bluuebunny/crossref_metadata_2025 huggingface dataset:
САМОПОМОЩЬ ПРИ СЕРДЕЧНОЙ НЕДОСТАТОЧНОСТИ: ИСПОЛЬЗОВАНИЕ ОПРОСНИКА EHFSCBS-9 В РЕАЛЬНОЙ КЛИНИЧЕСКОЙ ПРАКТИКЕ
Authors: Молдашева З.Б. , Сартаева А.Ш. , Зиналиева A.Н. , Дильмагамбетова Г.С. , Байкадамова Л.И.
Published: February 2025

Введение. Хроническая сердечная недостаточность – это распространённое гетерогенное заболевание с высоким риском смертности. В долгосрочном подходе к лечению сердечной недостаточности большое значение придаётся процессу управления самопомощью и поведению. Количество повторных госпитализаций и внеплановых медицинских визитов можно сократить, активно вовлекая пациентов в процесс самопомощи. Самопомощь является ключевым компонентом усиления управления болезнями, поскольку она способствует поддержанию контроля над симптомами и замедлению прогрессирования пациентов с хронической сердечной недостаточностью. Несмотря на незаменимую роль поведения самопомощи в лечении сердечной недостаточности, практика поведения самопомощи остаётся слабой, особенно в развивающихся странах, и требует дальнейшего изучения и внедрения. Цель обзора: Проанализировать результаты медицинских исследований, использующих опросник EHFScBS-9 в реальной клинической практике. Материалы и методы: Для обзора использования шкалы самопомощи при сердечной недостаточности EHFScBS_9 был выполнен поиск литературы в нескольких научных базах данных, включая PubMed, Scopus, Web of Science, Google Scholar. Результаты: Анализ литературы показывает, что самопомощь может значительно снизить риск госпитализации, уменьшить симптомы и повысить качество жизни. Однако для достижения этих результатов требуется обучение пациентов, постоянная поддержка со стороны медицинских специалистов и персонализированный подход к отдельным лицам. Выводы: На основании результатов включенных исследований опросник EHFScBS-9 можно рекомендовать для широкой оценки самостоятельного управления у пациентов с хронической сердечной недостаточностью, для планирования медицинской и социальной поддержки и дальнейшего изучения самопомощи у данной категории пациентов.
КЛИНИЧЕСКИЙ СЛУЧАЙ ОДНОВРЕМЕННОГО ДЕБЮТА НЕСКОЛЬКИХ ФОРМ КРАСНОГО ПЛОСКОГО ЛИШАЯ
Authors: Омарова Б.А. , Мангытаева Б.Б. , Сагатбаева А.Д. , Кульманбетов Р.И. , Тулегенова И.М.
Published: February 2025

Введение. Несмотря на многочисленные научные изыскания, этиология и патогенез красного плоского лишая окончательно не установлены. Существует такие теории возникновения красного плоского лишая как, неврогенная, вирусная, аутоиммунная, токсико-аллергическая. Данной патологии чаще подвержены женщины, в возрасте 40-65 лет, длительное время пациенты могут не обращаться за медицинской помощью, так как заболевание может протекать бессимптомно, безболезненно, но через некоторое время возможно развитие агрессивного течения, трансформация одной формы в другую, сочетание нескольких форм, малигнизация с упорным течением. Цель: описать клинический случай, демонстрирующий успешную диагностику и начало длительной терапии сочетанного проявления нескольких форм красного плоского лишая (буллёзной, эрозивной, атипичной) у одного пациента. Материалы и методы. Было получено добровольное информированное согласие на изложение и публикацию данного клинического случая, без указания личной информации. Стоматологическое обследование проводилось по стандартной схеме, проведено клинико-лабораторное исследование крови, пациент консультирован дерматологом, гинекологом, гастроэнтерологом. Пациент находится под динамическим наблюдением. Результаты. Первый этап лечения был направлен на устранение местных раздражающих факторов, уменьшение воспаления и укрепление сосудистой стенки, проведены дезинтоксикационная и десенсибилизирующуая терапии, что позволило добиться регресса эрозивной и буллёзной форм красного плоского лишая. Выводы: Наши результаты показали, что возможно одномоментное сочетание нескольких форм красного плоского лишая, в том числе особо агрессивной – эрозивной формы, связанной с высоким риском злокачественной трансформации. Мы рекомендуем поэтапное лечение, регулярное наблюдение за пациентами с КПЛ и чёткое разграничение оральной эпителиальной дисплазии и лишеноидных поражений для раннего выявления злокачественной трансформации. Необходимы дальнейшие исследования клинических факторов риска, связанных с проявлением одновременного сочетания нескольких форм КПЛ.
ОСОБЕННОСТИ ПРОЯВЛЕНИЯ НЕАЛКОГОЛЬНОЙ ЖИРОВОЙ БОЛЕЗНИ ПЕЧЕНИ У ЛИЦ АЗИАТСКОЙ НАЦИОНАЛЬНОСТИ
Authors: Рахметова В.С. , Саркулова С.М. , Уразалина Д.А. , Бахтиярова C.C. , Жангереева А.К.
Published: February 2025

Введение. Неалкогольная жировая болезнь печени представляет собой глобальную медицинскую проблему, которая становится всё более актуальной на фоне общей картины растущей заболеваемости и распространённости метаболических расстройств. Распространённость неалкогольной жировой болезни печени во всем мире оценивается в 32,4% и постоянно растет. Доля НЖБП в азиатских странах значительно ниже, чем в западных (20-30%), но в последнее время в данном регионе показатели возросли из-за роста ожирения, диабета 2 типа и метаболического синдрома. Основными причинами увеличения количества пациентов, страдающих данными заболеваниями в Азии, являются изменение образа жизни и индустриализация. Сегодня неалкогольная жировая болезнь признана основным хроническим заболеванием печени в Азии. Цель обзора: анализ существующих данных о проявлениях неалкогольной жировой болезни печени у лиц азиатской национальности. Материалы и методы исследования. В данном литературном обзоре мы провели анализ 39 научных статей, посвященных изучению особенностей проявления неалкогольной жировой болезни печени у лиц азиатской национальности. Результаты. В ходе исследования доступной нам литературы было обнаружено, что в Азии часто встречается постная форма неалкогольной жировой болезни печени, при которой жировая болезнь печени развивается без значительного увеличения массы тела. Также у азиатских пациентов выявлен генотип PNPLA3, который связан с большей уязвимостью к повреждению печени. Несмотря на отсутствие ожирения, риск осложнений, таких как фиброз, остается значительным, что подчеркивает необходимость комплексного подхода к диагностике и лечению, учитывающего не только ожирение, но и другие метаболические факторы. Выводы. Изучение особенностей неалкогольной жировой болезни печени у лиц азиатской национальности помогает углубить понимание этой сложной болезни, выявить возможные генетические и физиологические факторы, взаимодействие между этническими и возрастными факторами, что в последующем поможет разработать более эффективные стратегии диагностики и лечения, профилактических мер для различных групп населения. Кроме того, необходимо повысить настороженность врачей практического здравоохранения о возможном присутствии неалкогольной жировой болезни печени у лиц с нормальным индексом массы тела.
ИЗУЧЕНИЕ OКAЗAНИЯ ГИНЕКOЛOГИЧЕСКOЙ ПOМOЩИ ЖЕНЩИНAМ С OГРAНИЧЕННЫМИ ВOЗМOЖНOСТЯМИ
Authors: Султaнбекoвa Б. , Рaушaнoвa А. , Ахметжан A. , Ахтаева А. , Нурлaнкызы С.
Published: February 2025

Введение. Женщины с oгрaниченными физическими вoзмoжнoстями чaстo стaлкивaются с препятствиями, кoтoрые oгрaничивaют дoступ к медицинскoй пoмoщи. Пo срaвнению с другими женщинaми женщины с oгрaниченными физическими вoзмoжнoстями имеют бoлее высoкий урoвень сoпутствующих зaбoлевaний и связaнных с пoведением сoстoяний здoрoвья, кoтoрые являются фaктoрaми рискa беременнoсти. Цель обзора. Изучение oкaзaния гинекoлoгическoй пoмoщи женщинaм с oгрaниченными вoзмoжнoстями. Материалы и метoды. Был прoведен библиoгрaфический пoиск пo электрoнным бaзaм дaнных Pubmed, Cochrane, Google Scholar. Пoиск литерaтуры был прoведен пo ключевым слoвaм: «гинекoлoгия», «здoрoвье женщин», «oгрaниченные вoзмoжнoсти», «неравенство в сфере здравоохранения» . Пoиск был oгрaничен aнглийским языкoм. Критерием включения были все стaтьи нa aнглийскoм языке, сoдержaщие инфoрмaцию oб oкaзaнии гинекoлoгическoй пoмoщи женщинaм с oгрaниченными вoзмoжнoстями. Результaты. Исследoвaния пoдчеркивaют серьёзные прегрaды, с кoтoрыми стaлкивaются женщины с oгрaниченными физическими вoзмoжнoстями при пoлучении гинекoлoгическoй пoмoщи. Oни редкo прoхoдят регулярные oбследoвaния из-зa рaзнooбрaзных бaрьерoв, включaя структурные, финaнсoвые и инфoрмaциoнные прегрaды. Медицинские учреждения не гoтoвы oбеспечить рaвнoпрaвнoе и oриентирoвaннoе нa пaциентa лечение для этoй группы женщин, чтo ведёт к физическим и эмoциoнaльным труднoстям в прoцессе oбследoвaния и лечения. Oсoбoе внимaние уделенo тaкже женщинaм с интеллектуaльными или умственными нaрушениями, кoтoрые чaстo стaлкивaются с труднoстями в пoддержaнии менструaльнoй гигиены, недoстaткoм знaний o прoтивoзaчaтoчных средствaх и сексуaльнoм здoрoвье. Их уязвимoсть к зaбoлевaниям, передaющимся пoлoвым путём, и рaку шейки мaтки увеличивaется из-зa прoблем в oбщении с медицинскими специaлистaми, недoстaткa квaлифицирoвaнных пoстaвщикoв услуг и физических препятствий для oбследoвaния. Вывoды. Тaким oбрaзoм, существующие исследoвaния пoдче ркивaют неoбхoдимoсть рaзрaбoтки пoлитики, нaпрaвленнoи нa бoлее aктивную пoддержку прaв женщин с oгрaниченными физическими вoзмoжнoстями. Oсoбеннo вaжнo oбрaщaть внимaние нa пoтребнoсть в сoздaнии инклюзивных и oперaтивных стрaтегии , спoсoбствующих рaзвитию прaктик сaмoстoятельнoгo ухoдa у женщин с oгрaниченными вoзмoжнoстями. Крoме тoгo, вaжнo изучить пoдгoтoвку специaлистoв, пoвышеннoе сoблюдение гинекoлoгических кoнсультaции , a тaкже предoстaвление кoмплекснoи пoмoщи с учaстием трaнсдисциплинaрнoи кoмaнды, чтo мoжет спoсoбствoвaть укреплению здoрoвья и уменьшению нерaвенств.
ПРОБЛЕМЫ И ПЕРСПЕКТИВЫ ПЕРВИЧНОЙ МЕДИКО-САНИТАРНОЙ ПОМОЩИ В КАЗАХСТАНЕ
Authors: Шора Ж.Р. , Рахметова В.С.
Published: February 2025

Введение. Система первичной медико-санитарной помощи Казахстана претерпела значительные изменения с 1990-х годов. Основные реформы включают развитие семейной медицины, подушевое финансирование, цифровизацию и внедрение обязательного медицинского страхования. Несмотря на прогресс, система сталкивается с проблемами, такими как кадровый дефицит и неравномерный доступ к медицинским услугам. Цель работы: Изучить динамику развития системы первичной медико-санитарной помощи в Казахстане, выявить ключевые достижения и проблемы, а также предложить рекомендации для повышения её устойчивости. Материалы и методы: В исследовании использовались вторичные данные из отчетов Министерства здравоохранения, статистические материалы и международные источники. Анализ проводился по показателям, отражающим доступность и качество медицинских услуг, включая индекс охвата услугами, ожидаемую продолжительность здоровой жизни и плотность врачей общей практики. Результаты: С 2000 по 2021 год Казахстан продемонстрировал улучшение ключевых показателей: индекс охвата медицинскими услугами вырос до 82 (выше среднемирового уровня), а ожидаемая продолжительность здоровой жизни увеличилась с 56,1 до 65 лет. Однако пандемия COVID-19 негативно сказалась на этих показателях. Обеспеченность врачами общей практики в сельской местности значительно выросла, но кадровый дефицит сохраняется, особенно среди педиатров и участковых терапевтов. Выводы: Для повышения устойчивости системы первичной медико-санитарной помощи необходимы меры по устранению кадрового дефицита, укреплению инфраструктуры, увеличению доступности телемедицины и совершенствованию нормативной базы.
IMPROVING OPHTHALMIC CARE QUALITY AND ACCESSIBILITY THROUGH PATIENT-CENTERED APPROACHES AND STAFF TRAINING IN KAZAKHSTAN: A LITERATURE REVIEW
Authors: Kyrykbayev D.R. , Auezova A.M. , Zhurgumbaeva G.K. , Baymuratova M.A. , Dautaliyeva A.Zh. , Ruslanuly K.
Published: February 2025

Introduction. The primary goal of treating vitreoretinal pathology is to preserve visual functions, which significantly impacts the patient’s quality of life. Subjective testing of patients with vitreoretinal pathology is particularly relevant in determining appropriate management strategies. This study focuses on exploring modern organizational tools to enhance the quality and accessibility of ophthalmic care. Purpose of the review. To explore modern organizational tools to improve the quality and accessibility of ophthalmic care for the population. Materials and Methods. Publicly available articles were reviewed using scientific publication databases and specialized search engines, including PubMed, Mendeley, Scopus, Web of Science, and Google Scholar. The study emphasizes the evaluation of patient satisfaction and quality of care in ophthalmology through surveys, applicable across all levels of healthcare facilities. Results. The findings highlight the importance of regular monitoring by medical personnel to assess their knowledge levels in theoretical and practical aspects of preventive measures and surgical treatments for macular holes. Early diagnostic measures are also essential to improve access to specialized ophthalmic care. The value of using monitoring questionnaires to enhance interactions between ophthalmologists and patients has been well established. Conclusion. The study highlights the necessity of developing and implementing adapted specialized questionnaires for residents of Kazakhstan to improve patient satisfaction and care quality. Introducing these tools in medical institutions can significantly enhance ophthalmic care accessibility and outcomes.
ПОДДЕРЖКА СЕСТРИНСКОГО ЛИДЕРСТВА В РЕСПУБЛИКЕ КАЗАХСТАН
Authors: Максудова М.Х. , Алибекова Л.Д. , Султанова Г.Д. , Векленко Г.В. , Усебаева Н.Ж. , Муратхан А.Б. , Курманханова Р.Ж. , Шокай У.Д. , Оспанова Д.А.
Published: February 2025

Введение. Согласно оценке ВОЗ управление и лидерство в сестринском деле является механизмом создания благоприятных условий работы и признано одним из приоритетных областей для дальнейшего развития в системе здравоохранения. В этой связи наличие поддержки сестринского лидерства со стороны руководства медицинских организаций играет большое значение. Лидеры в сестринской службе способны менять рабочую культуру, могут влиять на законодательную базу в области здравоохранения. Поэтому важным является, чтобы медицинские сестры сами осознавали свою роль как лидера и понимали значение сестринского лидерства и его влияние на развитие системы здравоохранения. Цель исследования: выявить поддержку сестринского лидерства в медицинских организациях Казахстана Материалы и методы исследования. Поперечное исследование. Проведено онлайн-анкетирование в ноябрьдекабрь 2023 г. среди медицинских сестер Республики Казахстан. Выборка составляет 402 медицинских сестер. Результаты. Участники исследования отметили, что на рабочих местах имеется поддержка сестринского лидерства и менеджеров сестринской службы со стороны администрации. Выявлено, что уровень развития сестринского лидерства выше в тех медицинских организациях, где имеется руководство поддерживает руководителей сестринского дела как лидеров r=0,481 (р<0,01) Выводы. В ходе проведенного исследования среди медицинских сестер Республики Казахстан выявлено, что в настоящее время в медицинских организациях администрация оказывает поддержку развитию сестринскому лидерству и руководителям сестринской службы. Однако уровень сестринского лидерства находится на различных уровнях, что создает необходимость дальнейшего продвижения и изучения вопросов лидерства в сестринской практике.
METABOLIC DYSFUNCTION-ASSOCIATED FATTY LIVER DISEASE IN THE ELDERLY PEOPLE
Authors: Rakhmetova V.S. , Sarkulova S.M. , Urazalina D.A. , Azhibayeva N.K. , Zhangereyeva A.K.
Published: February 2025

Background. As the global population ages, metabolic disorders are becoming increasingly prevalent, leading to a significant rise in fatty liver disease among the elderly. Metabolic-associated fatty liver disease, formerly known as non-alcoholic fatty liver disease, is now the most common liver disease. Closely linked to metabolic disorders like obesity, type 2 diabetes, and dyslipidemia, Metabolic-associated fatty liver disease currently affects 24% of the adult population, equating to one billion individuals worldwide. Purpose of study. To analyze the incidence structure of metabolically associated fatty liver disease in the elderly population and to determine the mechanisms of liver aging that affect the prevalence and mortality from this disease in an elderly cohort of individuals. Material and methods of study. For this literature review, we analyzed 32 scientific publications, including reviews, original articles, and meta-analyses, published between 2012 and 2024. We conducted a literature search using databases such as Google Scholar, Web of Science, PubMed, Scopus, and Abridged Index Medicus. Results. Reviewing the available literature sources has revealed the prevalence of fatty liver disease peaking at the age of 40– 50 in men and 60–69 in women but decreasing in the older cohorts (>75 years). The mechanisms of liver cell aging influence the course of this disease in old patients have been identified as well. However, there are no data indicated concerning the direct impact on prevalence and association with fibrosis in the elderly population. Conclusion. Conflicting data on the prevalence of metabolic-associated fatty liver disease among the diagnosed elderly patients highlight the need for further research to realise the mechanisms underlying the age-related changes in the liver. The study of this disease in elderly persons is rather important to improve the quality of life and optimising medical care and developing prevention and treatment strategies.
INTERNATIONAL PRACTICES IN OPTIMIZING TIME METRICS FOR REPERFUSION THERAPY IN ACUTE ISCHEMIC STROKE
Authors: Makhanbetkhan S. , Turdaliyeva B. , Adilbekov Y. , Berdikhojayev M. , Medukhanova S. , Zhumabekov A. , Sarshayev M. , Moiynbayeva S.
Published: February 2025

Introduction. Acute ischemic stroke (AIS) remains one of the leading causes of mortality and long-term disability worldwide. Reperfusion therapy, including thrombolysis and thrombectomy, is highly time-sensitive and significantly improves patient outcomes when administered promptly. However, international variations in treatment time metrics and accessibility pose challenges to optimizing outcomes globally. The aim of the review:This review aims to analyze key time metrics for reperfusion therapy, such as door-to-puncture (DTP) and door-to-groin puncture (DTGP), in high- and upper-middle-income countries. It seeks to identify factors influencing treatment efficiency and outcomes to provide actionable recommendations for healthcare systems, including Kazakhstan. Materials and methods:A systematic review was conducted using PubMed, Scopus, Web of Science, and Cochrane Library databases. Studies published between 2005 and 2021 were included, focusing on time metrics such as DTP, onset-to-needle (OTN), DTGP, onset-to-groin puncture (OTGP), and onset-to-door (OTD). A total of 27 studies were selected using PRISMA guidelines, and key findings were extracted for comparative analysis. Results:The analysis revealed significant international variability in time metrics. Countries like Switzerland and the USA/Canada demonstrated shorter DTP and DTGP times, correlating with higher percentages of favorable outcomes at 90 days. These metrics underscore the importance of efficient emergency services and hospital workflows. Additionally, disparities in access to advanced stroke care were identified, particularly in regions with fewer stroke centers and endovascular specialists. Conclusion: This review highlights the critical role of optimizing time metrics to improve patient outcomes in AIS. International best practices, such as dual-modality approaches combining thrombolysis and thrombectomy, can serve as models for improving stroke care efficiency. For Kazakhstan, the findings emphasize the need to reduce treatment delays by enhancing prehospital systems and developing regional stroke centers. Future efforts should focus on addressing global disparities and standardizing key metrics to facilitate comparisons and improvements in care.
ASSESSMENT OF INVOLVEMENT OF SMALL AND MEDIUM PRIVATE PROVIDERS IN ALMATY MARKET OF MEDICAL SERVICES
Authors: Smagulov A.M. , Kurakbayev K.K. , Baimakhanov A.N. , Nurbakyt A.N. , Makhanbetkulova D.N.
Published: February 2025

Background. Involving small and medium businesses in the provision of medical services sets the task of rational use of existing resources in the healthcare system, and the development of a competitive environment in the market. The purpose of the study was to assess the existing distribution of small and medium entities by type of activity in health care, in dependence with stimulating factors and the involvement of small and medium businesses in public-private partnerships. Materials and Methods. The cross-sectional study was based on data from official sources on the number of small and medium-sized businesses, their share in the medical services market, and their participation in public-private partnerships. Results & Conclusion. The share of small and medium-sized businesses in Almaty ranges from 1.3 to 30%, depending on the type of medical services, while only 15% of the total number of private producers are involved in public-private partnerships, which indicates the need to develop development mechanisms cooperation.
GLOBAL EXPERIENCE OF ADVANCED PRACTICE NURSES IN PRIMARY HEALTHCARE: A LITERATURE REVIEW
Authors: Dostanova Z.A. , Yermukhanova L.S. , Baigozhina Z.A. , Taushanova M.K. , Abdikadirova I.T. , Sultanova G.D.
Published: February 2025

Introduction. The literature review emphasizes the growing role of advanced practice nurses (APNs) in primary healthcare at the international level. Amid global changes in healthcare systems, these professionals are becoming pivotal in enhancing both access to healthcare services and the quality of care. Aim of the Study. To investigate the global experience of advanced practice nurses within the context of primary healthcare. Materials and Methods. A search of scientific publications was conducted using the PubMed, Scopus, Web of Science, and Google Scholar databases, employing the following keywords: «advanced practice nurses,» «primary health care,» and «registered nurse.» Study Results. The study results indicate that advanced practice nurses significantly improve the quality of care and patient satisfaction. An analysis of various international models demonstrates the successful integration of these professionals into a team-based approach to treatment, leading to a reduction in physician workload and better population health outcomes. Moreover, the presence of clear regulatory frameworks and educational programs has been noted to enhance the efficacy of nurse practice, making them an integral part of the healthcare system. Conclusion. The international experience of advanced practice nurses showcases their significant impact on the efficiency of primary healthcare delivery. Recommendations for adapting successful practices can serve as a foundation for optimizing healthcare systems in various countries, ensuring more sustainable and effective healthcare provision.
РULMONARY-RENAL INTERACTIONS IN CHRONIC LUNG DISEASES — CURRENT STATE OF THE PROBLEM
Authors: Ibrayeva L.K. , Klassen O.S. , Alina A.R. , Bacheva I.V. , Nygimetova A.A.
Published: February 2025

Resume: The first quarter of the 21st century is nearly complete, and the medical community increasingly faces the challenges of global population aging and the steady rise in chronic disease prevalence. It is evident that the complete or partial loss of function in one organ affects the status of others. The kidneys and lungs jointly regulate fluid homeostasis, acidbase balance, immune response, and the production of biologically active molecules. For instance, renal insufficiency leads to fluid overload and hypertension, thereby exacerbating disease severity and increasing mortality in patients with chronic lung diseases, such as interstitial lung diseases and COPD. At the same time, chronic lung diseases significantly affect kidney health, both through hypoxia and nephrotoxic effects of treatments. Rheumatic diseases, such as systemic sclerosis, should be specifically highlighted, as fibrosis develops in both organs. Understanding inter-organ interactions is crucial for preventing complications and improving survival. These factors underscore the necessity of recognizing these interrelations when selecting treatment strategies. Ideally, a multidisciplinary approach should be employed, involving specialists in pulmonology, nephrology, and rheumatology. Collaborative efforts will enable proper treatment, timely detection, and prevention of complications. Applying knowledge of inter-organ relationships will not only improve the quality of medical care but also reduce the financial burden on the healthcare system. This review attempts to describe the mechanisms linking kidney damage and pulmonary dysfunction, with a focus on chronic kidney disease (CKD) and its impact on lung health. It emphasizes the importance of early detection of CKD and outlines potential biomarkers for assessing damage to both organs, as well as therapeutic targets. The search was conducted in electronic databases such as Scopus, Web of Science, PubMed, and Google Scholar, using relevant keywords: «COPD and CKD,» «ILD and CKD», «Kidney function and lung function,» «Renal dysfunction and respiratory failure.» The search span was 15 years, from 2009 to 2024, and included only open-access articles in English, encompassing all types of studies, focusing solely on adults and animal studies. Pediatric studies were excluded from consideration.
ASSESSMENT OF THE ACCESSIBILITY OF THE POPULATION OF ALMATY TO FREE DENTAL CARE
Authors: Madraimov N.B. , Gabdykalyk J.A. , Laktionova M.V. , Ryskulova A.R. , Baymuratova M.A. , Ryskulov G.P. , Imasheva B.I.
Published: February 2025

Background: Oral health is an important component of overall health and well-being. The ever-increasing cost of dental services makes it inaccessible to most of the population. The purpose of the study: to study the accessibility of the adult population in free dental medical care. Materials and methods: A cross-sectional study was conducted with the participation of 115 respondents who were interviewed using the author’s questionnaire «Patient satisfaction with the work of the dental service” and examined by a dentist to identify oral diseases. The main group consisted of people of retirement age who could receive dental care at the expense of the Republican budget – 36 people, the control group included people younger than retirement age (63 years for men, 61 years for women) — 79 people. Results: The survey showed that most patients go to the dentist only for urgent need, with a preventive purpose only 5% of the main group and 14% of the control group. None of the patients had an income below the subsistence level per family member, however, most patients in both groups need free dental care (87% of the main group and 80% of the control group), the main reason for rare visits to the dentist is financial constraints. Conclusions: Even though the respondents did not have an income below the subsistence level, most of them needed free dental care.
Development and Assessment of Boron, Cerium, and Silver Ternary-Doped Titanium Dioxide Photocatalysts for the UV-A Degradation of Ciprofloxacin Antibiotic
Authors: Mishra Yash , Kiran Dara , Mahalingam Hari
Published: February 2025

Due to the development of antimicrobial resistance, the continued presence of antibiotic residues in freshwater sources is a growing global concern and hence, it is necessary to degrade the antibiotics present in the polluted waters. In this study, three different boron, cerium, and silver ternary-doped TiO2 photocatalysts with specific compositions were synthesized using the eco-friendly EDTA citrate method. The specific compositions investigated here are B1Ce0.1Ag0.06TiO2, B1Ce1Ag0.06TiO2, and B1Ce1Ag0.1TiO2. From DLS analysis, the particle size of the synthesized catalysts was found to be in the range of 125 – 500 nm. The XRD spectra confirmed the presence of cerium. The DRS analysis showed the bandgap energy of the synthesized catalysts to be in the range of 2.7 – 2.8 eV. ICP-OES analysis was done to check the leaching of the dopants from the catalysts into the solution and the results showed that silver did not leach out while boron (~0.2 ppm) and cerium (~ 0.1 ppm) were present in trace amounts. The catalysts were also evaluated for the degradation of ciprofloxacin antibiotic under UV-A light. At optimized conditions, the best performing photocatalyst namely, B1Ce1Ag0.1TiO2, showed ~54% degradation of the antibiotic in 120 min. This is attributed to the increased amounts of cerium and silver. Although the performance under UV-A irradiation is not encouraging, these results suggest that these catalysts may be more effective under visible or solar light and further work is needed to check the effectiveness under visible light irradiation as well as on larger scales of treatment.
Accelerated ReaxFF Simulations of Vitrimers with Dynamic Covalent Adaptive Networks
Authors: Zheng Yiwen , Varshney Vikas , Vashisth Aniruddh
Published: February 2025

Vitrimers are a novel class of sustainable polymers with dynamics covalent adaptive networks driven by bond exchange reactions between different constituents, making vitrimers reprocessable and recyclable. Current modeling approaches of bond exchange reactions fall short in realistically capturing the complete reaction pathways, which limit our understanding the viscoelastic properties of vitrimers. This research addresses these limitations by extending and employing Accelerated Reactive Molecular Dynamics (ReaxFF) technique, thus enabling a more accurate representation of vitrimer viscoelas- tic behavior at the molecular level. Bayesian optimization is employed to select force field parameters within the Accelerated ReaxFF framework, and an empirical function is proposed to model temperature dependency, thereby controlling reaction probabil- ities under varying temperatures. The extended framework is employed to simulate non-isothermal creep behavior of vitrimers under different applied stress levels, heating rates and numbers of reactions. The simulation results agree with experimental findings in literature, validating the robustness of the framework.
Size Dependent Uncatalyzed Sulfite Oxidation in Aqueous Microdroplets
Authors: Gong Kedong , Sethuraman Sandhya , Tang Zifeng , McNeill V. Faye , Grassian Vicki
Published: February 2025

Aqueous aerosols and microdroplets exhibit unique chemical kinetics relative to the bulk phase. Aqueous aerosol and microdroplet chemistry, as it relates to multiphase atmospheric chemistry, also has major impacts on air quality and climate. Here, we have investigated uncatalyzed oxidation of sulfite (SO32−) to sulfate (SO42−) by O2 in aqueous microdroplets deposited on a superhydrophobic substrate, as a function of size, gas-phase composition, and temperature utilizing an environmental cell and in-situ micro-Raman spectroscopy. We show that the uncatalyzed sulfite oxidation driven by O2 in aqueous microdroplets is size-dependent across varying O2 concentrations and temperatures. Sulfite oxidation rates scale with the surface-area to volume ratio (i.e. 1/radius) of the microdroplet and oxidation occurs in the absence of any added catalysts. We use a resistor-based approach to model multiphase mass transfer and reaction in the experimental system and confirm that the observed size-dependent kinetics are consistent with slow bulk kinetics coupled with an efficient reaction at the interface (kII = 9.44×10-3 M-1 s-1, γs,0 = 9.27×10-10 at 298 K and 21% O2). Above a critical droplet radius, bulk kinetics dominate, but for sufficiently small sizes, which are relevant in the atmosphere, rates are accelerated due to the role of interfacial reaction. These results provide insights into chemistry in microcompartments and provide an outlook for improved representations of sulfate formation in atmospheric droplets and aerosols in large-scale atmospheric chemistry models.
Introducing the potential binding interface between the TRAIL-mimicking peptide and DR5 via alanine scan
Authors: Tripathi Nitesh , Chowdhury Arnab , Verma Neelam , Bandyopadhyay Anupam
Published: February 2025

Here, we harnessed the ligand binding interface between the 16-residue peptide (P) agonist to death receptor 5 (DR5), which is unexplored while pivotal for novel and selective cancer drug development, was unexplored. This solitary peptide ligand mimics the TRAIL (the natural ligand to death receptor) and controls cancer growth in vivo selectively, as reported earlier. We delved into the strategic merging of experimental and in silico structure-activity studies via alanine scanning mutagenesis of P, wherein cysteine residues were intact for structural integrity. Synthetic mutants enabled the mapping of the interaction engagement of each residue via antiproliferative activity studies on HCT116 cells. Further, in silico docking and MD simulations led us to interpret and model the 3D-binding interface between the P and DR5 protein. Notably, Trp1, Leu4, Arg7, Ile8, Gln12, and Arg15 were projected as ‘hot-spot’ residues crucial for primary interactions with DR5, which predominantly supports in silico investigations.
SUSTAINABLE DEVELOPMENT OF CITIES AND TERRITORIES: STRATEGIC DEVELOPMENT THEORY AND MEASUREMENT METHODOLOGY
Authors: Anfilov Dmytro
Published: February 2025

We aim to systematize the elements of sustainable development of cities and their social and ecological components in the theoretical and methodological basis of measuring the effectiveness of post-war reconstruction of the country. We study the theoretical and practical aspects of the economic growth of cities, and we systematize the components of implementing the strategy for achieving sustainable development of cities in the post-war period. We present the main characteristic features of the effective regional policy of the EU and Ukraine, highlighting the revitalization of polluted land plots in cities, the modernization of industrial facilities, the integrated regeneration of urban and rural areas, the development of environmentally friendly urban transport, and the development of residential construction.

We indicate the key aspects of the industrial waste management system in the city and the main directions: production-oriented, socially-oriented, and marketing management approaches. We find that organizational decisions should reflect the harmonious interaction of enterprises in handling industrial waste from the city-forming, city-maintenance, and city-building spheres. We characterize the key aspects of the industrial waste management system in the city and describe a set of methods for evaluating the sustainable development of cities.

We substantiate the importance of applying the scientific and methodological foundations of Zipf’s Law, considering it universal for measuring the effectiveness of the functioning of local communities and territories. We note that for the benefit of future generations, the strategy of sustainable development of cities should satisfy their own needs, covering social, economic, and ecological dimensions. We highlight the interrelationship of the components and present a scientific and methodological approach to determining the level of urbanization of the city, taking into account the index of sustainable development of the city based on Zipf’s law, which we have developed.
Utilization of the Particle Swam Optimization Algorithm in Game Dota 2
Authors: Armanto Hendrawan , Rosyid Harits Ar , Muladi Muladi , Gunawan Gunawan
Published: February 2025

Dota 2, a Multiplayer Online Battle Arena game, is widely popular among gamers, with many attempting to create efficient artificial intelligence that can play like a human. However, current AI technology still falls short in some areas, despite some AI models being able to play decently. To address this issue, researchers continue to explore ways to enhance AI performance in Dota 2. This study focuses on the process of developing artificial intelligence code in Dota 2 and integrating the particle swarm optimization algorithm into Dota 2 Team's Desire. Although particle swarm optimization is an old evolutionary algorithm, it is still considered effective in achieving optimal solutions. The study found that PSO significantly improved the AI Team's Desire and enabled it to win against Default AI of similar levels or players with low MMR. However, it was still unable to defeat opponents with higher AI levels. Furthermore, this study is expected to assist other researchers in developing artificial intelligence in Dota 2, as the complexity of the development process lies not only in AI but also in language, structure, and communication between files.
Principal Component Analysis on Convolutional Neural Network Using Transfer Learning Method for Image Classification of Cifar-10 Dataset
Authors: Al Haris M. , Dzeaulfath Muhammad , Wasono Rochdi
Published: February 2025

The current era was defined by an overwhelming abundance of information, including multimedia data such as audio, images, and videos. However, with such an enormous amount of image data available, accurately and efficiently selecting the necessary images poses a significant challenge. To address this, image classification has emerged as a viable solution for organizing and managing large volumes of image data, thereby mitigating the issue of cluttered image datasets. One of the most popular algorithms for image classification is the Convolutional Neural Network (CNN), which reduces the complexity of network structure and parameters by leveraging local receptive fields, weight sharing, and pooling operations. CNN is a type of artificial neural network specifically designed to process grid-like data, such as images, using convolutional layers to automatically detect local features. Nonetheless, CNN faces several challenges, such as gradient diffusion, large dataset requirements, and slow training processes. To overcome these issues, Transfer Learning has been widely adopted in CNN-based image classification, and Principal Component Analysis (PCA) has been employed to accelerate the training process. PCA is a technique used to reduce data dimensionality by identifying the principal components that account for most of the variance in the data. This study tested the efficacy of PCA-based CNN architecture using the Transfer Learning method on the Cifar-10 dataset. The results demonstrated that the PCA-based CNN architecture achieved the highest accuracy, with a testing accuracy rate of 0.8982 (89%).
Data Visualization of the Maturity Level From the Perspective of Business-IT Alignment at PT. XYZ
Authors: Juwita Oktalia , Arifin Fajrin Nurman , Ailsya Rachma , Nugrahani Tri Agustina
Published: February 2025

This article presents descriptive information about the results of the performance analysis and the maturity of the business-IT alignment process at PT.XYZ through the implementation of data-based visualization techniques within the SAMM perspective. This research is divided into four stages: preliminary research, data collection, data analysis, and organizational development analysis. Based on the results of the analysis using SAMM from the perspective of top-level management of an organization, PT. XYZ has achieved maturity in the attribute of good cooperation. This indicates that the company and organization understand the need for business-IT alignment for their development. However, the attainment level of maturity in the skills and communication attributes is less than optimal. This impacts the communication process and the distribution of information in the company’s development through IT implementation. This research only provides data visualization of the maturity achievements of PT. XYZ’s business alignment and information technology are based on the SAMM method. The process of analyzing the company's strategic alignment data and providing recommendations for implementing Information Technology to optimize the company's business was not included in this research.
Deep Learning-Based Inpainting for Reconstructing Severely Damaged Handwritten Javanese Characters
Authors: Damayanti Fitri , Yuniarno Eko Mulyanto , Suprapto Yoyon Kusnendar
Published: February 2025

Long-term storage at museums can damage ancient Javanese manuscripts; for instance, temperature changes and other factors may cause parts of the script to disappear. The Javanese script exhibits similarities among its letters, making the reconstruction process challenging, particularly when dealing with severe damage to the script's characteristic areas. To address this issue, we conducted a character painting technique that utilizes deep learning architecture, specifically the convolutional autoencoder, partial convolutional neural network, UNet, and ResUNet. The dataset contains 12,000 handwritten Javanese characters. We evaluated the restoration of missing characters using SSIM and PSNR metrics. The ResUNet achieves the best performance compared to other methods, with an SSIM value of 0.9319 and a PSNR value of 18.9507 dB. According to this study, the ResUNet models can reconstruct Javanese manuscripts with strong performance, offering an alternative solution to ensure the preservation and accessibility of these valuable historical documents for future generations.
Improving Urban Heat Island Predictions Based on Support Vector Regression and Multi-Sensor Remote Sensing: A Case Study in Malang City
Authors: Miftachul Arif Yunifa , Rohma Salma Ainur , Nurhayati Hani , Kusumadewi Taranita , Nugroho Fresy , Karami Ahmad Fahmi
Published: February 2025

The Urban Heat Island (UHI) phenomenon causes significant temperature increases in urban areas, adversely affecting the environment and public health. This research develops a prediction model of land surface temperature in Malang City using Support Vector Regression (SVR) with remote sensing data from Landsat-8, Sentinel-2, and SRTM. A cloud masking process is applied to improve image quality, while features such as NDVI, NDBI, NDWI, NDMI, elevation, and LST are calculated and normalized. The test results show that the Radial Basis Function (RBF) kernel with hyperparameters C = 10, Epsilon = 0.1, and gamma = 1 provides the best performance, with R² of 0.887, MSE of 1.625, and MAPE of 2.71%. This study shows that SVR with RBF kernel and appropriate tuning parameters can improve prediction accuracy. These results provide a strong basis for the development of more effective prediction models in managing UHI in big cities
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Evaluating customer perceptions of service quality in bangladesh's hotel sector: An empirical investigation
Authors: Rinu Fatema
Published: February 2025

Bangladesh's economy is dependent on the service sector, especially the hotel industry. In order to better understand customer satisfaction and boost business performance, hotel industry service quality must be measured. Given this significance, this study's objective is to measure the service quality of the hotel sector and customer satisfaction. This study used random sampling in the case of choosing tourist destination hotel customers. Customers of Bangladesh's one- to five-star hotels provided data for the study, which uses a quantitative methodology. This study used the SERVQUAL model, which has five dimensions: tangibility, reliability, assurance, responsiveness, and empathy. By reviewing various literature, it also added four more dimensions: prices, location, access, and service recovery. Reliability tests of items, frequency analysis, and a gap analysis between perceptions and expectations were carried out based on a questionnaire survey of 400 hotel patrons. This study's findings show that sample hotels' overall service quality is rated at -1.09. In every SERVQUAL dimension, visitors' perceptions of the quality of the services received fell short of their expectations. The expectations of the guests have not been met by the hotels in the sample. According to this study's findings, the management of a few chosen hotels should be aware of what visitors expect from them, standardize pertinent services in line with those expectations, establish appropriate guidelines, and provide the necessary resources to help them close the gaps between perception and expectation and improve customer satisfaction.
Enhancing bilingual vocabulary in government secondary schools: Challenges and suggestions
Authors: Dawson Sylvia , Padmanabha C. H.
Published: February 2025

The enhancement of bilingual vocabulary in government secondary schools is essential for equipping students with the linguistic skills necessary for success in a globalized world. Despite the considerable benefits of bilingual education, challenges such as rigid curricula, inadequate teacher training, limited resources, and varied student motivation impede effective vocabulary development. To address these issues, a comprehensive approach is needed, including curriculum integration, targeted professional development, and increased resource allocation. By adopting strategies such as bilingual instruction across subjects, fostering interactive and contextual learning, and involving families and communities, schools can better support students' bilingual vocabulary growth. Implementing these measures will help overcome existing obstacles and ensure that students develop a robust bilingual vocabulary that enhances their academic and professional opportunities.
Language is not taught, it is caught: Embracing the communicative approach in the primary classroom
Authors: Revathy B. R.
Published: February 2025

This paper explores the adoption of the Communicative Language Teaching (CLT) approach in primary classrooms, emphasizing that language acquisition is best achieved through meaningful communication rather than rote memorization. Drawing on Krashen's Input Hypothesis and Vygotsky's socio-cultural theory, the study highlights the importance of interaction, real-life application, and sociolinguistic competence in developing communicative skills. This paper further analyzes key strategies such as task-based learning, multilingual integration, and cultural awareness, demonstrating their effectiveness in enhancing linguistic competence and critical thinking in young learners. Finally, it addresses the challenges of implementing CLT in under-resourced classrooms and proposes solutions through teacher training and curriculum reform.
The effect of self-assessment on high school students' english writing achievement and motivation
Authors: Kagan Buyukkarci , Melike Ozelci
Published: February 2025

This study aimed to investigate the effects of self-assessment implementation on ninth grade students' writing competence and motivation. This study was designed as a quasi-experimental study and obtained quantitative data from questionnaires and writing scores. Qualitative data was gathered from semi-structured interviews conducted with the students. They completed an English writing motivation questionnaire and a pre-test writing task, and then they graded their pre-writing task by utilizing the rubric explained in detail. During the study process, the students completed 14 writing tasks, including pre- and post-test writing tasks, and assessed their own writing works with the simplified rubric. Meanwhile, this study also graded the students' writing tasks with the same rubric as the students. Before the completion of this study, the students took the same motivation questionnaire and writing task that they completed at the beginning of the study. The findings revealed that self-assessment increased the participants' self-awareness and writing scores. On the other hand, the self-assessment implementation did not lead to a significant difference in the students' English writing motivation, although the participants stated during the interviews that they found self-assessment useful and effective to improve their writing skills.