bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Parasetamol Tablet dengan Metode Fourier Transform Infra Red (FTIR)
Authors: Saragih Safitri , Suprianto Suprianto , Samran Samran
Published: January 2025

Background: Paracetamol, a widely used analgesic and antipyretic medication, is commonly prescribed in government healthcare facilities. The FTIR method provides rapid measurements by analyzing spectral graphs that reveal the functional groups within the tested compounds. According to the Indonesian Pharmacopoeia, VI Edition 2020, paracetamol content in tablet formulations must range between 90.0% and 110.0%. Objective: This study aimed to evaluate the paracetamol content in tablet preparations and assess their compliance with the 2020 Indonesian Pharmacopoeia standards and the packaging labels. Method: The research was conducted experimentally using FTIR spectroscopy. A solvent mixture of ethanol and distilled water (1:1) was employed, with analyses performed over the wavelength range of 4000–400 cm⁻¹. Results: The paracetamol content was found to be highest in tablet B (100.33 ± 1.003%), followed by tablet A (100.29 ± 1.002%), tablet D (100.24 ± 1.002%), and tablet E (100.14 ± 1.001%), with the lowest levels observed in tablet C (99.69 ± 0.996%). Method validation indicated an RSD value of 0.056%, confirming that the procedure was accurate and reliable. Conclusion: The findings demonstrate that the FTIR method is suitable for the quantitative analysis of paracetamol in tablet formulations. Moreover, the results meet the standards outlined in the 2020 VI Edition of the Indonesian Pharmacopoeia.
Factors affecting adoption of Smart watch and Fitness Band
Authors: Parita Bengali, Namrata Khatri
Published: January 2025

Awareness about health is a current development among the consumers, so is the tendency to make use of wearable healthcare devices. Smartwatch is the most popular wearable healthcare devices. Fitness bands also are popular for monitoring basic parameters of human body at consumer level. Most researches are done with the perspective of the technological or medical side pertaining to this topic. This technology is a part of non-conventional stream, that impact on the acceptance of the technology. Hence, the developers and manufacturers are eager to find out important factors that dominates the consumer’s behaviour.
Repeatability for weight at birth in Murrah buffaloes in the Zulia state of Venezuela
Authors: Pérez-González José Raúl , Montiel-Urdaneta Néstor Simón
Published: January 2025

To improve livestock breeding, aspects such as genetic evaluation must be included, and clear objectives must be set for the selection of animals to be future breeders. In this way, the estimation of repeatability (R) and its use in the most probable production capacity allows the detection of the best females, considering their performance and productive life. Birth weight (BW) is a character that has importance in the future performance of the animal. Therefore, strategies should be applied to improve this character. Thus, the application of the calculation of R is a strategy that should be implemented as a genetic improvement strategy; for this purpose, 257 BW records of the offspring of 108 buffaloes of the Murrah breed of the Mega 21 farm located in the Baralt municipality (Menegrande) of Zulia-Venezuela state were analyzed. The calves (birth weight) were weighed in the first 24 hours of the animal’s life. The following linear additive mixed effects model was used to calculate R and its variance components for BW:

is low, suggesting that a large number of data would be needed to evaluate the performance of a buffalo. The fixed effects (sex, season of birth, and year of birth) had a significant effect on BW (p<0.05). In this population, several records of a buffalo’s calves would be needed to correctly predict the BW of a future calf because R is low.
POTENSI ENDAPAN SANDSTONE FORMASI NGRAYONG DI LINGKUNGAN BACKSHORE SEBAGAI BAHAN PROPPANT UNTUK PROSES HYDROFRACKING
Authors: Hasiru Naya Vira Salsabila , Fernanda Demmy Tyandra , Pramudita Daffa , Rahutama Arif
Published: January 2025

Dalam kegiatan hydraulic fracturing diperlukan proppant yang berfungsi untuk mengganjal rekahan yang telah terbentuk agar tidak menutup kembali. Ada beberapa faktor untuk mendasari pemilihan proppant yang baik yaitu ukuran dari butir, kualitas (kandungan impurities), derajat kebundaran serta kehalusan permukaan butiran dari proppant. Setiap tipe proppant memiliki range ketahanan sendiri terhadap tekanan, maka dari itu penentuan ukuran butiran dari proppant sangat mempengaruhi untuk dilakukannya hydraulic fracturing dikarenakan semakin besar ukuran dari proppant, maka semakin besar juga permeabilitas dari proppant tersebut. Proppant yang memenuhi spesifikasi standard API RP - 19 adalah 90% dari berat sample material yang dilakukan sieve analysis harus berada di antara mesh dengan ukuran mesh terbesar dan terkecil yang telah ditentukan. Berdasarkan hasil sieve analysis 5 sample untuk menentukan distribusi ukuran butiran, didapat hasil persentase yang hampir sama antar sample. Sample 4 memiliki nilai persentase yang paling mendekati dengan standard API RP-19C yaitu 86%. Hasil kurang dari 90% yang didapatkan dapat disebabkan oleh dua kemungkinan, yaitu kurangnya sample yang diuji coba dan adanya pasir kuarsa yang berkurang saat pemindahan dari sieve shaker ke tempat pasir.
Crop Residues: The Unseen Threat to Environmental Sustainability
Authors: Suman Singh  , Nalin Kumar Mishra  , Pradeep Kumar Yadav  , Surendra Pratap Sonkar
Published: January 2025

Crop residue management (CRM) is a critical aspect of sustainable agriculture, addressing significant environmental and economic challenges. In India, the widespread practice of burning crop residues leads to severe air pollution, soil degradation, and health hazards. This paper explores the importance of CRM in environmental conservation, its economic potential, and the sustainable practices available for managing crop residues. It highlights the detrimental effects of residue burning, such as the release of harmful gases (CO2, CH4, NH3), and the subsequent loss of soil nutrients and biomass. The paper also discusses alternative CRM strategies, including composting, mulching, bioenergy production, and biochar utilization, which offer solutions to mitigate environmental damage while improving agricultural productivity and economic returns. The findings underscore the need for integrated approaches involving government policies, technological innovations, and farmer education to promote sustainable CRM practices across India.
Food access interventions in American Indian and Alaska Native communities: A scoping review
Authors: Carroll Danya , Mad Plume Lynn , Redvers Nicole
Published: January 2025

American Indian and Alaska Native (AI/AN) com­munities in the United States represent culturally rich food landscapes and traditions. Yet, food access in AI/AN communities remains a public health issue. Food access is influenced by a myriad of factors that may interact at different levels of the social ecological model (SEM). Using a scoping review methodology, we aimed to map the existing Indigenous community food access literature in the U.S. to the SEM to identify common SEM impact leve ls that food access interventions are targeting. We further reflected on AI/AN community food access intervention gaps to inform future interven­tion targets. A systematic search strategy was devel­oped and carried out in the following electronic databases with search dates from 1988 to 2023: PubMed, CINAHL, SocIndex, Academic Search Premier, ERIC, and Google Scholar. We then car­ried out deductive content analysis through the lens of the SEM using qualitative software. Intervention targets were identified based on what changes were highlighted in articles at each SEM level. Fourteen articles met the inclusion criteria for the review. Interventions targeted the ‘intrapersonal’ and ‘com­munity’ SEM levels the most, while the ‘institu­tional’ and ‘public policy’ levels were the least tar­geted. Food access was promoted in various inter­vention formats, including supporting community and/or school gardens; providing seeds; providing traditional foods at school, family, and community events; and providing meals to families. Our review found that valuable research has been conducted on AI/AN food access interventions with many interventions targeting multiple levels of the SEM. Our review highlights the importance of leveraging strengths in AI/AN communities to enhance food access, including through culturally aligned pro­grams and traditional foods. Further collaboration between AI/AN communities and researchers may lead to the development of more informed multi­level interventions that further integrate Indige­nous methodological and culturally based approaches to improving food access.
Restoring an Onkwehonwehnéha ecosystem
Authors: Jimerson Jasmine
Published: January 2025

This is a reflective essay on Akwesasne Freedom School’s effort to recreate a community of Onkwehonwehnéha (language and culture of the Original People) knowledge-sharing for healthier and more sustainable ways of living in alignment with the natural world, for the betterment of our people, the environment, and our Haudenosaunee (They Make a House, or the Six Nations) languages.

The Akwesasne Freedom School’s work promotes speaking our languages in our natural environment, reinforcing the ceremonial teachings inherent in songs, words, thanksgiving, and stories. The Akwesasne Freedom School intends to build relationships by creating an everyday learning environment that promotes relationship-building between families, plants, and medicines.

Rebuilding healthy Indigenous communities requires reconnecting the people and the earth by utilizing our Indigenous or Original foods, lan­guages, and cultural practices. This reflective essay seeks to validate further the critical relationship between Indigenous people and Indigenous food systems, its impact on learning, and the overall health and wellness of language, environment, and people. It could provide a model or framework for other Indigenous communities to emulate.
¿Para qué sirven los “universitarios fracasados”? Funciones estructurales del abandono universitario
Authors: Perales Miranda Víctor Hugo , Spedding Pallet Alison
Published: January 2025

El texto aborda el fenómeno de los “universitarios fracasados”, aquellos estudiantes que abandonan sus estudios sin obtener un título, y su relevancia en el contexto de la educación superior en Bolivia. El objetivo del estudio es examinar las trayectorias de estos estudiantes y el impacto del currículo oculto en su desarrollo personal y ocupacional. La metodología empleada es exploratoria y cualitativa, centrada en cinco estudios de caso, principalmente de la carrera de Sociología de la Universidad Mayor de San Andrés (UMSA), analizando tanto las trayectorias académicas como las competencias adquiridas fuera del currículo formal. Los resultados revelan que, a pesar de no completar sus estudios, muchos estudiantes desarrollan habilidades prácticas y sociales que les permiten generar un impacto significativo en sus comunidades y carreras laborales. Las conclusiones destacan la necesidad de reconsiderar la noción de éxito académico, sugiriendo que el currículo oculto juega un papel crucial en la formación de competencias valiosas que no siempre se reflejan en la obtención de un título
Características sociodemográficas de adultos mayores en situación de discapacidad del municipio de Charaña, La Paz Bolivia
Authors: Bautista Callisaya Miriam Doritza
Published: January 2025

Introducción. Se ha identificado en el Estado Plurinacional de Bolivia alrededor de 98263 personas calificadas por discapacidad, es de importancia en salud y de atención en políticas sociales estudiar la población adulta mayor con discapacidad del Municipio de Charaña, un área rural. El objetivo fue identificar las características socio demográficas de adultos mayores con discapacidad en área rural.
Material y métodos. Estudio cuantitativo, observacional, descriptivo de corte transversal, la técnica de recolección de datos fue encuesta, aplicadas a través de una ficha epidemiológica y carpeta familiar del Ministerio de Salud y Deportes de Bolivia.
Resultados. Se realizó 38 encuestas, el 36,8 % con edades entre 60 y 70 años, el 23, 68 % entre 71 y 80 años, fueron identificadas con discapacidad intelectual en un 34 %, con mayor predominio en el sexo femenino, carentes de una formación académica, acceso a la salud y políticas de salud. Lograron obtener su carnet de discapacidad 16 personas, debido a que en la calificación se encontraban con discapacidad grave y muy grave.
Conclusiones. A través de esta investigación las personas adultas mayores en situación de discapacidad accedieron a carnetización de identidad, calificación de grado de discapacidad y aplicación del bono discapacidad, en este grupo es importante realizar el seguimiento adecuado y oportuno mediante un equipo multidisciplinario.
Validez externa de la escala para medir hábitos alimentarios de adultos mayores
Authors: Paye-Huanca Erick Omar , Veliz-Rojas Lizet Helena , Sucre-Ramírez Arleth Juana
Published: January 2025

Introducción: Al hacer uso de un nuevo instrumento de medición, es condición previa demostrar sus propiedades de medición.

Objetivo: Determinar la validez externa de la escala para medir hábitos alimentarios de adultos mayores.

Material y métodos: Es un estudio de enfoque cuantitativo, psicométrico, de validación de instrumento documental. Se determinó la reproducibilidad del sistema entre operarios como medida de control de la eficacia del sistema según el ensayo de efectos Inter sujetos modelo univariante ANOVA que proporciona un análisis de regresión y un análisis de varianza para la variable dependiente, y para la validación de criterio entre instrumentos se empleó el índice de correlación R de Pearson y seguidamente para el rendimiento del instrumento se determinó la sensibilidad, especificidad y las curvas ROC con el programa estadístico SPSS v.18 y el programa informático Excel v.2016.

Resultados: Según la prueba Inter sujetos se observó mayor variabilidad en los adultos mayores (valor F = 11,6 p = 0,000), y sin diferencias significativas entre operantes al ejecutar la prueba (valor F = 0,17 p = 0,68). A la evaluación de ambos instrumentos tanto el de prueba y el de criterio externo se encontró una correlación positiva aceptable R de Pearson mayor a 0.8 con valor p de significancia menor a 0.05, se encontró validez de criterio. La sensibilidad fue de 82%, la especificidad del 81% y el área bajo la curva del 83%.
Conclusiones: La escala presento una reproducibilidad del sistema adecuada, presenta validez de criterio y tiene un rendimiento diagnóstico con un punto de corte óptimo.
Fiabilidad de una escala para medir hábitos alimentarios de adultos mayores
Authors: Paye-Huanca Erick Omar , Veliz-Rojas Lizet Helena , Sucre-Ramírez Arleth Juana
Published: January 2025

Introducción: Un instrumento de medición de tipo escala antes de ser aplicado, es necesario que cumpla los criterios de calidad que requiere condiciones de validez, fiabilidad y sensibilidad.
Objetivo: Determinar la fiabilidad de una escala para medir hábitos alimentarios de adultos mayores, La Paz - Bolivia.
Material y método: Se llevó a cabo un estudio con enfoque cuantitativo, psicométrico, de validación de instrumento de tipo documental, en 120 adultos mayores, el tipo de muestreo fue probabilística polietápico de los macro distritos de la ciudad de La Paz. Para determinar la fiabilidad del nuevo instrumento fue a través de los postulados de Cronbach, previamente se realizó el análisis de factorización de tipo exploratoria AFE y el análisis de factorización confirmatoria AFC con el programa estadístico SPSS versión 18 y el programa informático Excel 2016.
Resultados: La fiabilidad de un instrumento que mide hábitos alimentarios en adultos mayores consta de 24 ítems y 3 dimensiones, presenta ocho reactivos para cada uno de los dominios. La confiabilidad de la escala ítem-total fue del 96% (α de Cronbach = 0.962), cuando los dominios uno, dos y tres son rotados presentan valores por encima de 0.9. La fiabilidad de los dominios de la escala fue del 91%, (α de Cronbach = 0.913).
Conclusión: De acuerdo a los hallazgos encontrados se cuenta con un instrumento fiable que justifica su aplicabilidad.
Evaluasi Penyajian Multirepresentasi pada Buku Teks Kimia Kurikulum Merdeka pada Materi Kesetimbangan Kimia
Authors: Lusyana Lusyana , Aini Faizah Qurrata
Published: January 2025

Kesetimbangan kimia merupakan fenomena kompleks yang melibatkan perubahan pada tingkat mikroskopis (molekuler) dan sulit diamati secara langsung. Buku teks kimia berperan penting dalam membantu memahami konsep ini melalui penggunaan visual atau gambar yang menggambarkan fenomena kimia pada berbagai tingkatan. Pemahaman yang menyeluruh terhadap fenomena kimia dapat tercapai jika penjelasannya mengintegrasikan tiga aspek representasi, yaitu makroskopis, mikroskopis, dan simbolik. Namun, representasi kimia dalam buku teks kurikulum merdeka sering kali masih kurang tepat, bahkan beberapa materi diambil dari sumber internet. Penelitian ini bertujuan untuk menganalisis representasi kimia pada buku teks kimia kurikulum merdeka, khususnya pada materi kesetimbangan kimia, berdasarkan kriteria Gkitzia dkk, (2011). Hasil penelitian menunjukkan bahwa: (1) kedua buku teks paling dominan pada level multiple dengan persentase 50% dan 55% (C1), (2) fitur permukaan pada kedua buku teks kimia umumnya bersifat eksplisit dengan persentase 63% dan 64% (C2), (3) keterkaitan gambar dengan teks paling dominan pada kategori sepenuhnya berhubungan dengan persentase 50% dan sepenuhnya berhubungan dan tidak terkait dengan persentase 55% (C3), (4) keberadaan keterangan dominan pada kategori eksplisit, jelas, komprehensif, dan otonom dengan persentase 75% dan 55% (C4), serta (5) tingkat keterhubungan antar representasi dominan pada kategori tidak cukup terkait dengan persentase 75% dan 67%. Temuan ini diharapkan menjadi masukan untuk pengembangan buku teks kimia yang lebih representatif dan efektif dalam mendukung pembelajaran.
Solo e circo: o circo latino-americano em São Paulo
Authors: Filgueira Aline Araujo
Published: January 2025

O presente trabalho propõe pensar a imigração de artistas circenses latino-americanos para o Brasil, com foco para a cidade de São Paulo, como um movimento influenciado por mudanças políticas, sociais e culturais na América Latina e também por transformações artísticas dentro do próprio circo, a partir do surgimento do chamado novo circo no território latino. Uma vez que, esse deslocamento ocorre paralelo a uma onda de inovações e criações, e atrelado ao efervescente funcionamento de escolas de circo no Brasil e em outros países da América Latina. Buscando traçar uma ligação entre esses processos e indicar qual a sua influência para o circo brasileiro.
O BAILE CÚIER: a cultura ballroom e os corpos dissidentes dos padrões cis heteronormativos na criação de uma encenação
Authors: Melo Junior Sidnei Mauro de
Published: January 2025

Neste artigo, apresento de modo sintetizado o conteúdo de meu TCC. Ele teve como principal objetivo a utilização da cultura Ballroom e os corpos dissidentes dos padrões cis heteronormativos na concepção da encenação O BAILE CÚIER, que foi dirigida por mim no Curso de Artes Cênicas Direção Teatral da Universidade Federal de Santa Maria no ano de 2023. Entre os referenciais teóricos destaco Pelúcio (2014), Bertolotti e Medeiros (2019), Santos (2018) e Dos Santos e Scudeller (2020). Para a realização deste artigo, selecionei quatro das oito cenas da encenação para exemplificar como o processo de criação tornou possível a junção dos dois conteúdos principais da pesquisa para a construção de O BAILE CÚIER.
Desarranjo corporal e a preparação de atuantes teatrais
Authors: Nascimento Erique Rafael Lima
Published: January 2025

O presente estudo analisa o Desarranjo Corporal, idealizado por Ricardo Januário, com objetivo de investigar sua possível contribuição para a preparação corporal de atuantes teatrais. A pesquisa busca compreender e refletir sobre as características e dos princípios da preparação e do Desarranjo Corporal, a fim de estreitar a relação entre ambos. Realizado por meio de entrevista semiestruturada, levantamento bibliográfico e análise de aulas, este estudo se fundamenta como uma pesquisa descritiva com abordagem qualitativa, e tem como fundamentação teórica os estudos de Lobo e Navas (2003), Strazzacappa (2009; 2012), Azevedo (2012) e Lopes (2016).
Liderazgo educativo en crisis durante la pandemia por Covid-19 en América Latina
Authors: Orrego Tapia Vanessa
Published: January 2025

Las crisis promueven la emergencia de un tipo específico de liderazgo: el liderazgo educativo en crisis, cuyo estudio se expandió sustancialmente tras el COVID-19. En un esfuerzo para sistematizar su reflexión, el objetivo general de esta investigación fue identificar las principales prácticas del liderazgo educativo en tiempos de crisis surgidas durante la pandemia por COVID-19 en América Latina. Aplicando una revisión sistematizada bajo el formato SALSA, se encontraron 32 artículos cuantitativos, cualitativos y mixtos en la región. Los resultados identificaron siete prácticas, incluyendo el resguardo del aprendizaje, fortalecimiento de las capacidades de los docentes, toma de decisiones críticas, atención al bienestar socioemocional, distribución del liderazgo, refuerzo de la comunicación y aprender. Las conclusiones permiten profundizar en el contenido de esas prácticas de liderazgo educativo en crisis, pero sobre todo destacan la baja presencia de las práctica del aprender y la nula de hacer sentido, un fenómeno que es importante remediar para preparar a las escuelas para otras crisis que puedan venir en el futuro.
A Comparative Study on Growth of Fish Pangasius Hypophthalmus in Freshwater and Treated Wastewater
Authors: Tukaram Dr. Rawal Suvarna , Valsala Devasi Abhijith Simon
Published: January 2025

In the last few decades, pisciculture has seen the fastest growth in the food production sector. Fresh water availability is decreasing, which is becoming a major limiting factor to fish production and the gap between supply and demand constantly widens. In some countries around the world, treated wastewater (TWW) has been used for fish culture as a sustainable and alternative water resource for centuries. We conducted this study to compare the growth of the fish (Pangasius hypophthalmus) in fresh water and in treated wastewater. The purpose of this research work is to establish the suitability of treated wastewater for reuse, and to ensure that treated water is used for fish survival. Results suggest that the growth of fish in TWW in terms of weight, length and survival rate is potentially similar to that in freshwater.
Bioinformatics Analysis of a 4bp Homozygous Deletion Mutation of EDAR Gene Identified as an Important Cause of Hypohidrotic Ectodermal Dysplasia in Pakistan
Authors: Abdul Hameed  , Hafsah Muhammad  , Mir Asif , Muhammad Ajmal  , Siddique Nayyer
Published: January 2025

Hypohidrotic Ectodermal Dysplasia (HED) is a rare congenital disorder characterized by reduced hair, the absence of sweat glands, dental anomalies, and craniofacial malformations. This condition can be inherited through X-linked, autosomal recessive, or autosomal dominant modes of inheritance. Mutations in four specific genes (EDAR, EDA, WNT10A, and EDARADD) are known to cause HED. In a study to identify a pathogenic mutation in a consanguineous Pakistani family with the autosomal recessive form of HED, microsatellite markers were utilized to genotype the known loci associated with the disease. The condition in this family was mapped to the EDAR gene locus located on chromosome 2q11-q13. Upon screening the EDAR gene, a novel homozygous 4bp deletion (718delAAGA) in exon 8 was identified, which segregated with the disease phenotype. This 4bp deletion in the EDAR gene results in a frameshift and early termination of translation, producing a truncated protein of 245 amino acids instead of the normal length of 539 amino acids. Various bioinformatics tools were employed to analyze the pathogenic mutation linked to a significant number of HED cases in Pakistan. I-TASSER was used to model the protein structure, CASTp facilitated the identification of various pockets, and STiTCH 3.1 determined EDA to be the ligand for EDAR. Docking analysis were conducted for both the mutant and wild-type EDAR proteins with EDA, revealing notable differences in the interaction sites between the docked complexes of the normal and mutant forms of EDAR with the ligand EDA. These analyses provided insights into the protein's structural features, active sites, interactions, and the overall impact of the mutation.
Qualidade no Ensino Superior a Distância: avaliação discente
Authors: Santos Roberta Souza , Vieira Kelmara Mendes
Published: January 2025

O objetivo deste estudo é analisar a qualidade dos cursos a distância por meio da avaliação dos discentes, contemplando várias dimensões como: professores, feedback dos professores, tutores, ambiente virtual de aprendizagem, entre outras. A metodologia da pesquisa foi quantitativa, tipo survey com uso da estatística descritiva. Os resultados indicam que os discentes avaliam os cursos como de alta qualidade.
Educação Híbrida na formação de gestores: uma visão experiencial dos impactos e desafios
Authors: Pimentel Fernando Silvio Cavalcante , Rita Luciana Peixoto Santa , Pinto Ibsen Mateus Bittencourt Santana , Junior Natalício Batista dos Santos , Amaro Maria Julia Rodrigues
Published: January 2025

Este  estudo  explora  a  o  planejamento,  o  desenvolvimento  e  a  avaliação  de  uma  disciplina  em  um  curso  de  especialização  de  gestores  para  a  Educação  Híbrida.  O  objetivo  foi  analisar  a  experiência  de  um  componente  curricular  que  trata  de  Educação  Híbrida.  A  metodologia  é  qualitativa,  com  uma  abordagem  da  Pesquisa  Experiencial  (Kolb,  1984).  Os  resultados  indicam  que  o  modelo  oferece  flexibilidade  e  acesso  ampliado,  apesar  dos  desafios  na  manutenção  e  engajamento  dos  participantes.
The Effect of Company Size, Leverage, and Profitability on Financial Performance in Food and Beverage Companies Listed on the Indonesian Stock Exchange (BEI) in 2022-2023
Authors: Erika Safitri  , Ramadhan Harahap  , Hernawaty
Published: January 2025

The aim of this research is to examine the effect of company size measured by the natural logarithm (Ln) of total assets, leverage (DAR) profitability (ROE) on financial performance (NPM) in food and beverage companies in 2022-2023. The sample selection technique was purposive sampling, the sample consistend of 31 companies. The data analysis technique in this research is descriptive statistical analysis, classical assumption testing, multiple linear regression analysis, hypothesis testing and coefficient of determination testing, by applying software SPSS ver 25. The results of the research show that partially company size has no significant effect on financial performance, while individually (partially) leverage and profitability have a significant effect on financial performance. Simultaneously company size, leverage and profitability have an effect on financial performance.
КОНЦЕПТ «К.И. САТПАЕВ – «ЗВЁЗДНАЯ ЛИЧНОСТЬ» В ПОРТРЕТНОМ ОЧЕРКЕ
Authors: Мухамадиев Х.С. , Удербаев А.Ж. , Амралинова Б.Б.
Published: January 2025

Работа посвящена рассмотрению портретной характеристики личности К.Сатпаевав воспоминаниях в жанре очерка признанных учёных и государственных деятелей, знавших его прижизни, работавших вместе с ним или общавшихся с ним в различных жизненных ситуациях. Цель,основные направления и идеи научного исследования связаны с рассмотрением тезиса, а именноконцептуального высказывания: «К.И. Сатпаев – “Звёздная личность” эпохи». По мнению академикаИ.И. Артоболевского, известного ученого в области теории механизмов и машин, «К.И. Сатпаевявляется яркой звездой на небосклоне мировой науки». Научная и практическая значимость статьиопределяется общим интересом к творческой личности К.И. Сатпаева и подтверждается актуальностьюсамой темы: о нём «написано более 60 книг, более 3.5 тысячи статей и высказываний, созданооколо десятков фильмов». В основе методологии исследования – сравнительно-сопоставительный,литературоведческий и концептуальный анализ метафорических высказываний о личности ученого вконтексте научных трудов новейшего времени, о перспективности и продуктивности их применения,являющихся по своей сути феноменами, обеспечивающими понимание исследуемого объекта. Основныерезультаты и выводы исследовательской работы: посредством рассмотрения научных подвиговК.И. Сатпаева и сравнительного анализа концептуальных метафор в структуре очерков разных авторов,в работе представлена портретная характеристика К.И. Сатпаева на фоне его научных свершений.Ценность проведённого исследования и вносимого вклада данной работы в соответствующую областьзнания: рассмотрены и сопоставлены яркие высказывания о великом учёном, системно соотнесенныес метафорическим концептом «звёздная личность» для понимания творческой деятельностиК.И. Сатпаева. С точки зрения заявленной темы для молодого поколения открываются более широкиевозможности в плане изучения творческой биографии учёного как научного и культурного феномена,что позволяет взглянуть по-новому на известные литературные явления.
NAVIGATING NANO LANDSCAPE: A COMPREHENSIVE REVIEW OF CUBOSOMES IN DRUG DELIVERY AND BEYOND
Authors:   Department of Pharmaceutics, Bharati Vidyapeeth’s College of Pharmacy, Sector-8, CBD Belapur, Navi Mumbai – 400 614, Maharashtra, India, Sanap Dhanashree P.
Published: January 2025

Cubosomes are nanostructured liquid crystalline particles formed from specific combinations of amphiphilic lipids, and they are used as biocompatible drug delivery vehicles. Cubosomes typically have a diameter of about 200 nm, making them suitable for various biomedical applications. They are composed of amphiphilic lipids, which have both hydrophilic and hydrophobic parts, stabilizers to maintain their structure, and water. The specific ratios of these components are crucial for forming and stabilizing the cubosomal structure. Cubosomal preparations often exhibit a viscous yet transparent appearance, which can be advantageous for their ease of handling and potential applications. The unique three-dimensional honeycomb structure of cubosomes provides them with a large surface area. This is beneficial for loading a significant amount of bioactive substances, enhancing their therapeutic potential. Cubosomes can be prepared using relatively straightforward methods, which is advantageous for scalability and industrial production. This review article provides an overview of cubosomes, their types, composition as well as pharmaceutical applicability.
COMPLIANCE TO CONFORMANCE
Authors: Nair Gopakumar
Published: January 2025

Dear Reader,

“Compliance” is a term used and practiced extensively in the Pharmaceutical Industry. None of us are strangers to compliance, such as regulatory compliance, GMP compliance, compliance to pharmacopoeial standards, SOPs and many more. There are extensive treatises and even research studies on compliance. On a routine practice, the reference to compliance is extensive. However, an equally or more important terminology is “conformance”. Pharmaceutical Industry needs to move on from legal and regulatory compliances to “conformance”.
Legislative Framework for Decentralized Administration in Addressing River Pollution
Authors: Syaprillah Aditia , Fuad Shehab Shyyab
Published: January 2025

effectiveness, particularly concerning water pollution in river areas. This research examines the legislative framework for protecting river basins in Indonesia, focusing on water pollution. Using a normative legal research method with a conceptual approach, the study analyzes the current legislative provisions and their implementation. The findings reveal that while existing environmental protection laws and technical regulations for supervision and sanctions are in place, they have not been fully effective in preventing river pollution across various regions in Indonesia. The research suggests that a new legislative direction is necessary to support the successful implementation of environmental protection, advocating for sustainable and green legislation. It emphasizes the need for stronger administrative sanctions against individuals and corporations responsible for pollution and calls for enhanced oversight from national to local authorities. The study concludes that strengthening decentralized administration is crucial to ensuring that laws and regulations are correctly implemented, thereby addressing the persistent issue of river pollution and promoting long-term environmental sustainability.
Criminal Penalties for Foreigners Engaged in Illegal Fishing Indonesia's ZEE Impact SDGs
Authors: Irawan Aris , Asneliwarni  , Julian Ransangan  , Rachel Georghea Sentani
Published: January 2025

This research examines Indonesia's criminal law policy's readiness to address fisheries and maritime crimes within the Indonesian Exclusive Economic Zone (ZEEI) and its implications for achieving the Sustainable Development Goals (SDGs). However, in the UNCLOS 1982, Indonesia is prohibited from imposing imprisonment as a sanction for violations of the ZEEI, allowing only fines as penalties. In addition to normative issues, structural issues also pose challenges to effective law enforcement and threaten the success of Indonesia's SDGs in the fisheries sector. Using a normative legal research method with statutory, conceptual, and historical approaches. The study finds that Indonesia, as a signatory to UNCLOS 1982, must carefully adapt international rules into national laws without compromising its sovereignty. To achieve legal certainty, imprisonment as an alternative to fines should be considered. Fisheries crimes in ZEEI negatively impact SDGs by depleting fishery resources, destabilizing the economy, violating human rights, and causing environmental damage. Judges play a critical role as enforcers of legal certainty and protectors of Indonesia's national interests through the Judicial Power Law. This research underscores the need for legal reform to strengthen Indonesia’s sovereignty and sustainability in maritime law enforcement.
Indonesia’s Safeguarding of Human Rights to Achieve Sustainable Development Goals: Insights from Australia’s Experience
Authors: Andini Orin Gusta , Muhammad Riyan Kachfi Boer
Published: January 2025

Indonesia has undertaken numerous initiatives to protect human rights through ratified national and international legal frameworks. However, challenges remain as violations of fundamental human rights persist. This article examines Indonesia's efforts to protect human rights through sustainable development and compares them with Australia's approach to achieving sustainable development goals (SDGs) by upholding human rights. The study employs a normative legal research method, utilizing statutory and case approaches. Primary and secondary data sources, including relevant human rights legislation, were analyzed qualitatively to address the research objectives. The findings indicate that Indonesia is committed to the SDGs and identified national targets aligned with Goal 16, emphasizing peace, justice, and strong institutions. While Indonesia and Australia face similar challenges in achieving the SDGs, Indonesia can draw lessons from Australia’s experience, particularly in strengthening the localization of SDGs and adopting objective success measures. Implementing data-driven evaluations of progress, gaps, and opportunities will enable Indonesia to formulate relevant policies and improve SDG outcomes. Adopting such measures is crucial for Indonesia to advance its human rights agenda and sustainable development efforts more effectively.
Maritime Piracy and the Sustainable Development of Nigeria’s Blue Economy
Authors: AMAO Funmi Oseyemi , Adesanya Olusegun Paul , Ola Adegboyega Adedolapo
Published: January 2025

Maritime security is critical to economic stability, international trade, and national sovereignty, yet the sector faces persistent challenges, particularly in regions like the Gulf of Guinea (GoG). Threats such as piracy, illegal fishing, smuggling, oil theft, and terrorism undermine regional stability and economic development. Nigeria, as a major player in the GoG, has prioritised maritime security through national diplomacy to address these challenges. Therefore, the study examined the detrimental impact of maritime piracy on Nigeria’s blue economy. The study employed a mixed-method design, integrating qualitative and quantitative approaches to provide a comprehensive analysis. Key Informant Interviews were conducted to gather qualitative insights, while structured questionnaires were used to collect quantitative data from stakeholders. The study identified significant challenges of maritime security in Nigeria, such as poor performance in fishing, fisheries and maritime tourism. The study revealed a strong correlation between piracy and the decline of Nigeria’s blue economy, highlighting the need for robust security measures to curb piracy and unlock the full potential of Nigeria’s coastal resources for sustainable economic development. The study concludes that national diplomacy is indispensable for tackling the complexities of maritime security in the Gulf of Guinea (GoG). The study recommended that Nigerian government should strengthen its maritime security diplomacy, enhance regional collaboration, and secure its maritime interests effectively by expanding bilateral and multilateral partnerships, enhancing resource allocation for maritime operations, fostering trust through transparent engagements, and strengthening institutional frameworks.
Avaliação do uso de corticoides em infecções virais do sistema respiratório
Authors: Bressan Aline Alencar de Andrade , Queiroz Roger Antonio Morais , Rezende Ana Carolina Aguiar , Nicoletti Sabrina de Araújo , Lima Pedro Lucas Enomoto , Paiva Maykon Jhuly Martins de , Silva Kenia Dorneles , Pereira Karoline Alves , Miranda Gustavo Antonelle Faria , Silva Júnior Nilson Afonso da , Cunha Arthur Lima , Feitosa Isadora Carvalho , Vieira Açucena Ramos Alencar , Póvoa Carolline Sabino , Curcino Luana Martins
Published: January 2025

Introdução: Os corticoides, versões sintéticas dos esteroides adrenais, são agentes anti-inflamatórios e imunossupressores potentes. Eles desempenham um papel crucial no tratamento de várias condições inflamatórias e autoimunes. Durante infecções virais graves como COVID-19, SARS e MERS, os corticoides reduzem citocinas pró-inflamatórias, mitigando tempestades de citocinas que causam graves danos pulmonares e falência de múltiplos órgãos. Metodologia: este estudo envolve uma revisão bibliográfica utilizando termos como "Adrenal Cortex Hormones", "Respiratory System" e "Virus Diseases" em bases de dados SCIELO, PUBMED, LILACS, BVS e MEDLINE. Foram selecionados 22 artigos de 2019 a 2024 para revisão. Resultados: os corticoides suprimem respostas imunes excessivas e inflamação, reduzindo a produção de citocinas e afetando células imunes. Na COVID-19, a dexametasona reduz mortalidade e necessidade de ventilação, mas aumenta os riscos de infecções secundárias e pode prolongar a eliminação viral. Para a gripe, os benefícios são mistos; enquanto a inflamação é reduzida, há um maior risco de infecções secundárias. Nos surtos de SARS e MERS, os corticoides reduziram a inflamação pulmonar, mas prolongaram a eliminação viral e causaram efeitos adversos. Os benefícios incluem redução de sintomas, diminuição da hospitalização e melhora da função pulmonar. No entanto, os riscos incluem imunossupressão, hiperglicemia, osteoporose, hipertensão e psicose rara. Crianças enfrentam problemas de crescimento e densidade óssea, e nas infecções por RSV, os corticoides podem ser menos eficazes. As respostas variam por subgrupo. Discussão: A revisão apoia a eficácia dos corticoides na redução de sintomas e mortalidade em infecções respiratórias virais graves como a COVID-19. No entanto, os benefícios variam para outras infecções virais como gripe, SARS e MERS. Diferentes subgrupos de pacientes requerem abordagens personalizadas devido a respostas e riscos variados. Conclusão: Os corticoides são eficazes em casos graves de COVID-19, reduzindo mortalidade e necessidade de ventilação ao modular respostas inflamatórias excessivas. No entanto, seus benefícios em outras infecções virais respiratórias são variáveis e associados a riscos significativos, exigindo um gerenciamento cuidadoso e mais pesquisas sobre dosagens, tipos e efeitos a longo prazo para subgrupos específicos de pacientes.
Análise SWOT no planejamento estratégico hospitalar: um estudo em Palmas-TO
Authors: Alencar Naíla da Silva , Borges Cejana Marques , Campos Augusto de Rezende , Castro Darlene Teixeira , Bitar Alan Barros , Faria Denilda Caetano de , Souza Dalila Maria Vieira , Amordivino Stelamar do
Published: January 2025

O presente estudo teve como objetivo aplicar a análise SWOT no planejamento estratégico hospitalar em Palmas-TO, identificando as forças, fraquezas, oportunidades e ameaças que impactam a gestão e o desempenho das instituições de saúde da cidade. Para isso, foram coletados dados por meio de questionários aplicados aos gestores do hospital. Os resultados mostraram que as principais forças identificadas foram a qualificação da equipe de profissionais, infraestrutura adequada e a relação positiva com a comunidade. As fraquezas apontadas incluíram a escassez de recursos financeiros e humanos, a resistência à mudança e a falta de integração entre setores. As oportunidades envolveram o crescimento populacional, a digitalização e a implementação de novas tecnologias, enquanto as ameaças externas foram relacionadas à concorrência com hospitais de maior porte, instabilidade econômica e regulamentação excessiva. A análise SWOT evidenciou a importância de um planejamento estratégico bem estruturado, que permite aos gestores identificar áreas de melhoria e explorar oportunidades, garantindo maior competitividade e sustentabilidade. Este estudo reforça a necessidade de uma gestão hospitalar eficiente, adaptável e focada em resultados, especialmente diante de um ambiente dinâmico e desafiador.
Propósitos e reflexões de uma reforma curricular em pensamento computacional realizada em uma rede municipal de ensino do Brasil
Authors: Tironi Cristiano Rodolfo
Published: January 2025

As discussões sobre o pensamento computacional se evidenciaram nos últimos anos nos contextos em que se debatem a sua inserção como componente curricular da Educação Básica. Um desses contextos trata das relações entre pensamento computacional e pensamento matemático e as suas implicações presentes em uma reforma curricular. Assim, a pesquisa tem como objetivo analisar o processo de inserção da disciplina Matemática e Pensamento Computacional (MPC) no currículo da Educação Básica de um Município na Região Sul do Brasil sob a perspectiva da formação continuada de professores. Sua abordagem é qualitativa com um desenho de pesquisa-ação, no qual os participantes são professores da Rede Municipal de Ensino desse Município, incluído o próprio pesquisador. Dentre os resultados da pesquisa, notou-se que uma reforma curricular deve ser realizada de forma democrática e colaborativa, que a voz dos professores no processo da reforma é um dos fatores fundamentais para o êxito da mesma e a urgência em políticas públicas mais voltadas para a formação continuada de professores, pautadas no contexto de cada rede de ensino e alinhadas às demandas do século XXI.
Estudo do hidrogênio verde no Estado do Ceará a partir da perspectiva da pegada hídrica e fluxo de água virtual
Authors: Silva Francisco Ayrton Juca da , Sabiá Rodolfo José , Silva Yonar Cavalcante da , Silva Karolyne Gomes , Maia Everson Araújo , Oliveira Neto Jaime Francelino de , Feitosa Sarah Rodrigues , Oliveira Edna Rayne Andrade
Published: January 2025

A crise energética é um problema global que afeta a disponibilidade e o custo das fontes de energia. Aliado a isso, a queima de recursos não renováveis libera grandes quantidades de CO2 na atmosfera, aumentando o efeito estufa e, consequentemente, as temperaturas globais. No Brasil, a transição para energias renováveis não é apenas uma necessidade ambiental, mas também uma oportunidade para promover o desenvolvimento econômico sustentável. O hidrogênio verde é considerado o principal vetor energético que fará parte dos esforços de mitigação de emissões de GEE nas próximas décadas. O objetivo desse estudo é, por meio de teses, dissertações e artigos acadêmicos, realizar uma revisão sistemática de literatura com o intuito de reconhecer o processo produtivo da cadeia do hidrogênio, combinado a visão da pegada hídrica e do fluxo de água virtual. Conclui-se que o hidrogênio, se produzido de forma correta, permite reduzir significativamente as emissões de dióxido de carbono, principalmente em indústrias e nos transportes. Porém tal tecnologia ainda encontra barreiras de alto custo e dificuldade de implementação, podendo ser reduzida a médio e longo prazo com o avanço da tecnologia mundial.
Comprehensive Management of Hepatocellular Carcinoma: Epidemiology, Prevention, Diagnosis and Therapeutic Advances
Authors:   Power and Engineering, East Coast Group (Omera Renewable Energy Limited), Dhaka, Bangladesh, Saad Asadullah Muhammad Hossain
Published: January 2025

Hepatocellular carcinoma (HCC) is a major worldwide health problem with increasing incidence and mortality. This article reviews the epidemiology, prevention, diagnosis, and treatment of HCC. In this review, we consider the important risk factors of HCC, such as viral hepatitis, non-alcoholic fatty liver disease, and alcohol, taking particular notice of their prevalence in different global areas. Opinions on preventive strategies such as vaccination against hepatitis B virus and surveillance programs for high-risk populations are recorded. In conjunction, this review details current diagnostic modalities, including imaging techniques (ultrasound, CT, and MRI) and serum biomarkers (AFP), as well as the limitations associated with each. These topics will move from surgical resection and liver transplantation to locoregional, systemic therapies, along with a focus on the latest developments in targeted therapy and immunotherapy. Although there have been positive advances in HCC management, the early Detection and successful treatment of advanced-stage disease still pose significant challenges. The ultimate goals of future research in this area may be to develop new therapeutic agents and improve the accuracy of diagnostic imaging based on disease biology for personalized medicine.