bluuebunny/crossref_metadata_2025 huggingface dataset:
EVALUASI SISTEM ZONASI TERHADAP DAYA SERAP PESERTA DIDIK
Authors: Pramaisella Andika
Published: October 2023

This study entitled the evaluation of the zoning system on the absorption capacity of SMA Negeri 1 Cibadak. The general objective of this study is to determine the extent of the success of the zoning system implemented by the government in absorbing students in SMA Negeri 1 Cibadak. This study uses a descriptive method using a qualitative approach. Data collection using the interview method. The population in this study were the principal, the head of PPDB, and 2 teachers at SMA Negeri 1 Cibadak. The data were analyzed by data reduction and drawing conclusions in narrative form. The results showed that the evaluation of the zoning system began with the acceptance of new students using the provisions set by Education and Culture, 50% of students from the zoning system, 25% of the achievement pathway, 15% of the affirmation pathway, and 5% of the parent transfer path. The quality of the school is very decisive for the results of this program, the quality of the teachers also determines the final outcome of the students who attend SMA Negeri 1 Cibadak. This is the spirit of the achievement of students and schools. For this reason, SMA Negeri 1 Cibadak feels that it can accept all students in the implementation of new students for the 2020-2021 school year quota of 36 people times 12 classes
PENGARUH PEMBELAJARAN DI RUANG TERBUKA HIJAU TERHADAP MOTIVASI BELAJAR SISWA
Authors: Farhana Fiki Zida
Published: October 2023

The development of facilities and infrastructure that is increasingly being carried out in urban  areas and the rapid growth of population causes limited green open space. Green open space itself has many benefits if its existence is cared for and managed well. Green open spaces are also being intensely procured in cities, provinces and schools. It is known that if a green open space is provided at school it can be one of the learning resources that can optimize learning achievement. Because unwittingly green open space which contains a place to grow plants with a green color that can reduce boredom when students feel monotonous learning activities. So it is hoped that the opening of green open land in schools as a source of learning can increase student motivation and can improve student’s critical thinking processes about everyday phenomena.
URGENSI PENGEMBANGAN KECERDASAN EMOSIONAL GURU BAGI EFEKTIFITAS PEMBELAJARAN
Authors: Maslikha Maulidia Nur , Wulogening Hiyasintus Lie , Tenis Maria Olinda
Published: October 2023

Penelitian ini dilatar belakangi oleh pentingnya kecerdasan emosional guru bagi efektifitas pembelajaran. Tujuan penelitian ini adalah untuk mengetahui pentingnya kecerdasan emosional guru dalam pembelajaran di kelas yang sesuai dari sudut pandang Landasan Psikologi Guru. Penelitian ini diharapkan mampu membuat proses pembelajaran di sekolah menjadi lebih baik khususnya pada kualitas guru. Penelitian ini menggunakan angket terbuka ditujukan kepada guru, hasil data dianalisis secara kuantitatif dan kualitatif. Hasil penelitian menunjukkan bahwa setiap guru harus memiliki kecerdasan emosional yang baik, sehingga dapat berinteraksi dengan siswa dan menjadikan pembelajaran lebih kondusif.
Meningkatkan Kinerja Pengajaran Melalui Supervisi Kolegial di Sekolah
Authors: Wariah W
Published: October 2023

The teacher plays a central role in the implementation of education because it directly interacts with students in the implementation of learning activities that will determine the quality of students output. However, from the findings in the field, it was found that the achievement of school quality report cards at the elementary level, especially in the educators and education personnel standard, still did not achieve the expected results. In particular, this study aimed to determine the picture of the implementation of collegial supervision, find a number of supporting and inhibiting factors in the implementation of teacher collegial supervision, and determine the impact of collegial supervision on teacher performance in 16 public elementary schools in Bungunsari district, Purwakarta regency. The method used is descriptive quantitative and correlation analysis using the SPSS 26 application. The results of this study indicate that there is a positive and significant relationship in the medium category between collegial supervision and teacher performance. As for the recommendations given based on the results of the study, the principal should be able to improve the implementation of collegial supervision, especially in running a structured dialogue with teachers, in order to maintain the rhythm of their performance.
Akuntabilitas dan Transparansi Pengelolaan Dana Bantuan Operasional Sekolah (BOS)
Authors: Ramdhani Riski Fauzi
Published: October 2023

The research conducted at state madrasa aliya 5 Ciamis aims to determine accountability and transparency in the management of school operational assistance funds. The problem with this research is that there are schools that are not yet transparent and accountable for managing school operational assistance funds. The method used in this study is a qualitative descriptive method where data collection uses interview techniques with the principal and treasurer as well as observation of documents related to school operational assistance funds. Qualitative descriptive data analysis technique The results of this study indicate that state madrasa aliya 5 Ciamis, in managing school operational assistance funds, has implemented the principles of accountability and transparency quite well. This can be seen from the accountability reports of school operational assistance funds to related parties from the regional to the central level, as well as the form of transparency to the public, even though the media is limited. However, there are still shortcomings or the need for improvement in several aspects, such as transparency and the absence of digital media used to disseminate reports on the use and receipt of school operational assistance funds.
Sistem Kesejahteraan Sumber Daya Manusia di Sekolah Menengah Pertama Negeri 31 Bandung
Authors: Sopwandin Iwan , Pribadi Luthfi Audia
Published: October 2023

This study aims to analyze how much the level of welfare is obtained by workers at junior high school 31 Bandung, both in terms of material (wages, allowances and bonuses/rewards) and non-material (facilities) at junior high school 31 Bandung. The results of this study indicate that (1) the level of welfare of the workforce, both educators and education staff, at junior high school 31 Bandung is sufficient both in terms of salary following the regional minimum wage, benefits and incentives/rewards (2) junior high school 31 Bandung is also provide many allowances and adequate facilities to employees at junior high school 31 Bandung for the welfare of the workforce, both educators and education staff. (3) The level of job satisfaction of employees at junior high school 31 Bandung is categorized as quite high, this is indicated by the suitability of the salary with the workload received by employees, the condition of the school environment and the attitude of a leader and co-workers who are good and in line with expectations so that the impact arises comfort and employee satisfaction at work
The Role of Carbon Footprint Calculation in the World Trade in Liquefied Natural Gas (In Russ.)
Authors:   ITMO University, Gagulina N.L. , Selezneva M.A. ,   GLE LLC
Published: October 2023

The paper considers the main prerequisites for the development and growth of the liquefied natural gas (LNG) market. The rates of energy transfer and the role of natural gas in the global energy balance are estimated. The international practice of LNG cargo trade has been considered, the market capacity has been analyzed, and the most promising sales directions have been identified. In the course of the study, the main approaches to quantify-ing the carbon footprint were compared, the life cycle of LNG was considered, and a conclusion was made about the need to create a unified integrated accounting methodology to ensure the most complete and transparent system for disclosing information about LNG cargoes.
Control Systems Synthesis of Maximum Robust Stability Degree Based on Vertex Critical Root Diagrams
Authors: Gayvoronskiy S. A. , Ezangina Tatiana Al. , Sobol A. V.
Published: October 2023

The article solves the problem of operative selection of the redundant onboard equipment complex components configuration of the suitable in the current operating conditionаs in the interests of ensuring high fault tolerance of the complex, as well as achieving other operational and technical characteristics. The basis of the redundancy management system of the complex consists of configuration supervisors — as program subjects according to the number of its competitive configurations of heterogeneous and nonuniform equipment worked out in advance. The choice of the preferred configuration is proposed to be carried out by performing multi-level arbitration, which includes two phases of paired arbitration of computers and paired arbitration of configuration. It is proposed to include the means of both types of arbitration in each configuration supervisor, which ensures its self-sufficiency when participating in a competitive selection. The second part of the article is devoted to the computer’s arbitration for the implementation of redundancy management functions. The approach is applicable to a computing environment with many comparable computing devices and contains 2 phases. In the first phase, a preliminary selection of a competing pair of computers — as applicants for the implementation of redundancy management functions in them is carried out. In the break between the phases, the pair computers implement the procedures for pair arbitration of configurations given in the first part of the article. In the second phase, the final choice of the -computer is made, in which the supervisor who won the arbitration will be implemented. In order to achieve the maximum possible centralization of selection procedures and, as a consequence, the exclusion of " bottlenecks" in terms of reliability of places, additionally proposed: the organization of secure data exchange between computers based on distributed registry technology; the procedure of paired arbitration of computers, consisting in mutual cross-validation of dominant supervisors of a pre-allocated pair by comparing preference matrices, including information parcels of arbitration objects. A methodological example that demonstrates the features of the system functioning in the conditions of computers degradation is given. The proposed approach can be used to solve the problems of reconfiguration control of heterogeneous computing facilities of technical objects on-board equipment complexes.
Development of approaches to the evaluation of pharmacotherapy effectiveness for chronic hepatitis C
Authors: Narkevich I. A. , Tsitlionok E. A.
Published: October 2023

Objective: to analyse the consumption pattern of antiviral therapy (AVT) for chronic hepatitis C on the example of an infectious hospital.Material and methods. The study was based on data from 380 discharge summaries of an infectious diseases hospital for 2011–2019. The criterion of sampling was the established diagnosis of chronic hepatitis C. The first line therapy regimens were analyzed and compared; the calculations were based on direct treatment costs of the study sample. The pharmacoeconomic effectiveness of therapy was assessed by calculating the cost-effectiveness ratio (CER).Results. A retrospective analysis of patients’ sampling allowed to establish a general profile: a 40-year-old man with hepatitis C virus genotype 1 and a mild degree of liver fibrosis. A total of 18 international nonproprietary names (17 trade names) were used for AVT. The pattern of drugs prescribed correlated with the clinical guidelines for the studied period and allowed to distinguish the beginning of the transition from interferonbased regimens to direct-acting antivirals (DAAs). The change in the treatment paradigm was associated not only with increased efficacy in achieving a sustained virologic response, but also with minimization of side effects. The high frequency of prescribing interferon regimens as AVT was accompanied by low rates of achieving virus elimination (63.69%), high frequency of relapses (12.88%), as well as the lack of response to pharmacological correction (21.32%) and premature discontinuation of therapy due to adverse events (2.11%). A total of 142,450,414.91 rubles was spent on the first line pharmacotherapy in the study cohort during the study period. Costs per 1 patient with the diagnosis “chronic hepatitis C” and F0–F3 fibroses according to METAVIR were 372,847.07 rubles with achieving sustained virologic response without relapse in 66% of cases, costs per patient with F4 liver lesion were 398,464.73 rubles (45,16%, respectively).Conclusion. The findings allow us to note the transition from interferon-, nucleoside- and nucleotide-based drugs to DAAs, which can be associated with an increase in therapy effectiveness and proportion of cases with sustained virologic response achieved along with a decrease in the number of adverse events. The results of the study have practical implications for building a strategy for hepatitis C virus elimination in terms of choosing effective pharmacotherapy while reducing the economic burden.
Validity and reliability of a test battery for assessment of functional capacity in adults Down syndrome
Authors: Rodrigues Silveira Jennifer , Gomes da Silva Gabriel , Carriconde Marques Alexandre
Published: October 2023

Introdução : Pessoas com síndrome de Down (SD) apresentam capacidade funcional (CF) reduzida devido às características físicas e intelectuais decorrentes da síndrome. A bateria de testes proposta neste estudo fornecerá aos estudiosos da área uma ferramenta para avaliar e prescrever corretamente treinamentos para melhorar a autonomia e independência de indivíduos com SD. Objetivos : Este estudo teve como objetivo verificar a validade de conteúdo e a confiabilidade de uma bateria de testes criada para avaliar a CF em adultos com SD. Métodos:Os testes da bateria incluem caminhada de 10 metros, Time up and go, apoio unipodal, sentar e levantar da cadeira, levantar do chão, vestir camisa e o teste do café da manhã, além das variáveis ​​massa corporal e altura. A validade de conteúdo foi estipulada pela avaliação de seis juízes e a confiabilidade foi verificada intraavaliador e interavaliador. O índice de validade de conteúdo (IVC) e o índice de correlação intraclasse (ICC) foram utilizados para verificar a confiabilidade. Resultados:Participaram da etapa de confiabilidade 41 pessoas com SD, com idade entre 18 e 59 anos (média 30,41 e σ +-10,41), massa corporal média de 68,57 kg (σ +-17,18) e altura média de 1,52m (σ +- 0,09). Observou-se IVC de 0,95 para a bateria de testes. Em relação ao CCI intraavaliador foram encontrados todos os valores acima de 0,83 e os valores interavaliadores foram acima de 0,75, com exceção do teste de camisa (CCI=0). Conclusões: A bateria criada é uma das primeiras propostas para avaliar a CF de pessoas com SD e apresenta validade de conteúdo e confiabilidade para avaliação de pessoas com SD.
Influence of proprioceptive training on fencing athlete’s performance: a clinical trial
Authors: Vasconcelos Gabriela , Cini Anelize , Grazioli Rafael , Minozzo Felipe , Lima Cláudia
Published: October 2023

Background: Fencing is an agility sport and is characterized by a combination of short and frequent high intensity movements. Proprioceptive training demonstrates a positive effect on athletes' performance. It is effective in increasing dynamic balance by reducing ankle muscle reaction time that stabilize joint. Objective: The aim of this study was to verify influence of a 12-week proprioceptive training program on ankle instability, jumping performance and ankle muscle’s reaction time during Lunge in fencing athletes. Method: The study was a clinical trial, non-randomized, with 19 fencing athletes from 14-35-year-old, divided in intervention group (n=10) and control group (n=9). The study was performed in four stages: familiarization of jump performance; pre-intervention; intervention and post-intervention. At pre-intervention was evaluated jump performance, ankle muscle reaction time and functional ankle instability. At the intervention, athletes performed 30 minutes of proprioceptive training for 12 weeks, three times a week. At post-intervention, the same pre-intervention tests were performed. Data were presented in mean and standard error, submitted to the Generalized Estimates Equations test with Bonferroni post hoc. The level of significance was 0,05. Results: Jump performance decreased significantly in both groups. Anterior tibial muscle reaction time did not differ neither in any of groups, nor in any of legs. The peroneus longus and lateral gastrocnemius reaction time decreased significantly in both groups. Regarding functional ankle instability, athletes had instability at pre- and post-intervention time. Conclusion: Proprioceptive training program was not able to improve jump performance, nor to decrease ankle muscle reaction time or improve athletes' perception of ankle stability.
Infrared thermography in the diagnosis of Achilles tendinitis. A randomized double-blind pilot clinical trial
Authors: Lopes-Martins Rodrigo Alvaro Brandão , Luis Filipe Beloni Luis Filipe , Santos Maria Célia Galvão , Cadenas Bueno Felícia , Lopes-Martins Pedro Sardinha Leonardo , Naterstad Ingvill Fjell , Bjordal Jan Magnus , Ferreira Carlos Renato , Souza Sá Filho Alberto , Leonardo Patrícia Sardinha
Published: October 2023

Background: The Achilles tendon (AT) is the widest and most resistant of the osteoarticular system and has the greatest load-bearing capacity. It is involved in daily functioning and sports activities performance. Exposure to excessive stress on the calcaneus tendon (CT) can prevent an effective repair process and favor permanent injuries. Tendinopathy is a clinical syndrome resulting from disorientation of AT fibers, and inflammatory signs characteristic of tendinitis or tissue degeneration present in tendinosis can be found. The condition can manifest itself through functional changes accompanied by clinical signs such as crackling, tenderness, pain and edema. Infrared thermography is used to trace thermographic profiles, capable of detecting thermal changes related to pathologies. Objectives: The main goal of this study was to correlate AT region thermograms with clinical and functional characteristics in healthy individuals with CT pathology. Methods: The present work consists of a double-blind pilot randomized trial, of qualitative and quantitative nature. Individuals with TC tendinopathy, classified in the Tendinopathy Group (TG) and individuals without tendinopathy, classified in the Control Group (CG) participated. Assessments were performed to characterize the subjects belonging to the TG and CG: anamnesis, infrared thermography, referred pain, crepitation and thickness on palpation, algometry, arch sign test and Royal London Hospital test, pain on passive dorsiflexion, pain on lifting the heel and long jump. Results: The results obtained in infrared thermography were consistent with those obtained in the clinical evaluation for TG and GC. The results demonstrate that healthy tendons presented an average temperature difference of 0.24 ± 0.15 ºC between legs with a maximal difference of 0.4 ºC. On the other hand, unilateral tendinopathy presented an average temperature difference of 1.2 ±  0.9 ºC, however, this difference could be as big as 5.1 ºC. Conclusion: It is concluded that infrared thermography can be used safely and non-invasively to aid in the diagnosis of Achilles tendon tendinopathy.
Do tourism, economic complexity and globalization affect economic growth? New empirical evidence in the context of TALC theory and accounting for cross sectional dependence
Authors: Panagiotou Thomas , Katrakilidis Constantinos
Published: October 2023

This paper investigates the Tourism Led Growth (TLG) relationship, incorporating the law of economic returns and the Tourism Area Life Cycle (TALC) theory, along with economic complexity and globalization. To measure tourism accurately, principal components analysis is employed, integrating five tourism-specific variables for 127 countries spanning the period from 1995 to 2020. The empirical analysis utilizes advanced panel dynamic models that account for cross-sectional dependence, yielding robust evidence of a nonlinear TLG relationship. Our findings reveal an inverted U-shaped curve characterizing the TLG relationship in both the short and long run, highlighting distinct impacts of tourism specialization in each time frame. Specifically, higher levels of tourism specialization in the short run can lead to diminishing returns to scale in the long run. Furthermore, our analysis demonstrates that cultural globalization positively facilitates the TLG relationship, while economic complexity exerts a negative influence on the impact of tourism on economic growth.
The dynamic effect of macroprudential policies on income inequality: some evidence
Authors: Konstantinou Panagiotis , Rizos Anastasios , Stratopoulou Artemis
Published: October 2023

We study the dynamic effects of the adoption of macroprudential policies on income inequality over the period 1990 - 2015. We utilize local projections for horizons up to 5 years, and we document that the implementation of borrower-targeted MAPs increases income inequality since they pose obstacles to the access to credit based on household-specific characteristics; however, some financial institutions-targeted instruments (i.e., capital and reserve requirements) lead to a more equal income distribution.
Memory recovery through gene therapy with a single chain antibody fragment selective for Aβ oligomers in a model of Alzheimer’s disease in rats
Authors: Colettis Natalia-Claudia , Oberholzer Maria-Victoria , Cercato Magali , Habif Martin , Selles Maria-Clara , Salas Daniela , Sebollela Adriano , Klein William-L. , Epstein Alberto-L. , Salvetti Anna , Ferreira Sergio-T. , Jerusalinsky Diana
Published: October 2023

Strong evidence supports the hypothesis that synapse damage and memory impairment in early Alzheimer disease (AD) might be due to synaptic failure caused by amyloid beta oligomers (AβOs). We demonstrated the preclinical efficacy of a single-chain variable-fragment (scFv) antibody NUsc1 that selectively targets a subpopulation of AβOs; NUsc1 prevented AβO-induced inhibition of long-term potentiation in hippocampal slices and short-term memory impairment in mice. Since specific targeting of AβOs by NUsc1 may be a substantial improvement in target engagement and efficacy for AD therapy, we developed an adeno-associated virus (AAV) vector to drive neuronal expression of NUsc1 within the brain. AAV-NUsc1 rescued short-term memory (STM) for objects and congeners interaction in mice AD models. Purpose: In heterozygous McGill-R-Thy1-APP transgenic (Tg+/–) rat model of AD, progressive amyloid pathology is accompanied by cognitive impairment involving long-term memory (LTM) decline. LTM in a novel-object-recognition (NOR) task was impaired in 4-month-old (Tg+/–) male rats, suggesting that they are unable to form/evoke such discriminative memories. Hence, we investigated if AAV-NUsc1 treatment could rescued this memory. Methods: 10-12 weeks-old either Tg or wild type male rats were i.c.v. infused with AAV-NUsc1. Two months later, short-term exploratory behavior, habituation to an open field (OF), object discrimination and LTM for objects were assessed. Results: AAV-NUsc1 treated Tg rats were able to successfully perform the task 24 h after training, denoting recovery of LT discrimination capacity and LTM formation. Wild type rats successfully performed the task either treated or not with AAV-NUsc1. Also, exploration and short-term habituation to an open field was preserved in Tg+/– rats either treated or not. Conclusions: Our present and previous results suggest that AAV-NUsc1 represents a significant advance in gene therapy, supporting the feasibility of immunotherapy using viral vector-mediated NUsc1 gene delivery as a potential therapeutic approach in AD.
Prospective memory in patients with Mild Cogntive Impairment
Authors: Cuesta Carolina , Cores Evangelina-Valeria , Rivara Magalí , Soccini Lucía , Politis Daniel-Gustavo
Published: October 2023

Prospective memory is the ability to remember to carry out intended actions and to evoke delayed intentions. It constitutes a crucial skill for the daily functioning of the elderly. It might also be prematurely compromised in neurodegenerative diseases. In the Latin American region, objective measures are not available for its assessment. The aim of this study is to explore prospective memory in patients diagnosed with Mild Cognitive Impairment. As specific aims, we intend to discriminate the performance on prospective memory between patients and healthy subjects and to study the internal consistency and inter-examiner reliability of the Mini Cóndor Test (a simplified version of a prospective memory test developed in Argentina). We carried out a comparative study including a group of 20 patients with Mild Cognitive Impairment and a group of 20 healthy subjects as control group. Results indicated significant statistically differences between groups in prospective memory performance in favor of the control group. The Mini Cóndor Test met adequate scores for internal consistency and inter-rater reliability. These preliminary results suggest that the Mini Cóndor Test has the potential to early detect cognitive impairment associated to neurodegenerative pathology.
Disolución sintomática y trastornos alimentarios
Authors: Covetta Alejandro N. , Palma Pablo-Alejandro
Published: October 2023

El presente articulo intenta realizar una descripción histórica de los relatos que orbitan los Trastornos de la Conducta Alimentaria (TCA) siendo estos sostenidos tanto por el contexto, la ética, la religión, la moral, las costumbres, las creencias entre muchas. Estos discursos muchas veces resultan tan verosímiles, racionales y coherentes haciendo que el diagnostico se dilate en el transcurso del tiempo por los profesionales intervinientes y solapadamente el TCA se hipertrofia de tal manera que el impacto tanto físico, emocional y social es de tal magnitud que las intervenciones terapéuticas deben ser incisivas y determinantes a fin de evitar un desenlace fatal. Se verá en el transcurso del articulo como en diversas épocas y contextos el discurso con las explicaciones racionales cargadas de emociones puede variar, pero el objetivo y la finalidad queda intacto. El término disolución sintomática se refiere al desvanecimiento del síntoma en el contexto que se despliega pasando desapercibido, mimetizándose con el entorno.
A Student, a Master or a Scribe? Criteria for Determination and their Practical Application on the Material of the “Compilatio Prima” by Bernardo of Pavia in the Canon Law Manuscript Bamberg. Can. 19
Authors: Kazbekova Elena
Published: October 2023

The question of the criteria for determining those who left notes and glosses in the manuscripts of roman and canon law of the 12th—14th centuries, about distinguishing the marginal marks of students, teachers, legal scholars, their assistants or secretaries, scribes, university officials, is relevant both for historians and for paleographers. The article summarizes the criteria developed in historiography for their identification. Study of the features of the “Compilatio Prima” by Bernardo of Pavia in the manuscript Bamberg. Can. 19 raises the question of the need to study the glosses of the master Damasus Hungarus using the methods of paleography and codicology. The decretals “Super specula” (1219) and “Ecclesia Rothomagensis destituta pastore” (1222) in the manuscript Bamberg. Can. 19 made it possible to clarify its dating (after 1222 — the middle of the 30s years of the 13th century) and gave new data on the chronological boundaries of the period of teaching activity of Master Damasus Hungarus.
A ironia romântica e a educação do olhar: uma reflexão sobre a obra de José Saramago
Authors: Carreira Shirley de Souza Gomes
Published: October 2023

Este artigo propõe uma reflexão sobre a ironia em obras de José Saramago, não apenas como estratégia retórica, mas principalmente como ironia romântica. Desde Memorial do Convento, Saramago teceu um elo entre as intrusões dos seus narradores e um projeto subliminar de educação do olhar que veio a se revelar explicitamente por meio da epígrafe de Ensaio sobre a cegueira. Ao usar ostensivamente o discurso irônico que David Muecke (1995) categoriza como instâncias de ironia situacional e ironia verbal, Saramago aponta para “valores éticos [que] nascem entranhados no valor estético” (GRAÇA apud JAMES, 1995, p.11); valores que continuam a interpelar o passado e o presente.  Assim, o artigo propõe a análise do ethos irônico que se manifesta nos romances de Saramago como presentificação da mundividência do autor.
FACTORS IN THE DEVELOPMENT OF INFORMATION AND COMMUNICATIONS COMPETENCE IN TEACHERS IN A UNIVERSITY’S INTERNAL SYSTEM OF ADVANCED TRAINING
Authors: Merezhko Mikhail , Kireeva Olga , Gubarenko Irina
Published: October 2023

The study focuses on factors in the development of information and communications competence. The authors describe the effects of the application of information and communications technology as an applied basis for developing information and communications competence and the impact of pedagogical competence as a theoretical foundation for the development of information and communications competence. The obtained findings are utilized to propose a comprehensive strategy to facilitate the development of information and communications competence in teachers accounting for all the significant factors in it and including all stages of its development. The presented approach ensures consistent development of the competencies from the development of educational programs and to self-assessment and further improvement of the skills. Considering such factors as the educational environment, individual psychological characteristics, pedagogical experience, and motivation, it is possible to considerably improve the results and utilize ICT to increase the quality of education.
SPECIAL-EDUCATIONAL INTERVENTION ORIENTED TO THE DEVELOPMENT OF COMMUNICATION OF A CHILD WITH HYDROCEPHALUS UP TO THE THIRD YEAR OF LIFE
Authors: Olejarova Maria , Hlebova Bibiana
Published: October 2023

This paper focuses on the issue of communication in children with hydrocephalus at an early age. The clinical picture of hydrocephalus is variable. Therefore, we talk about symptomatic speech disorders. The aim of the paper is a theoretical treatment of the subject and a proposal of research solutions oriented on the possibilities of developing the communication skills of these children. The research design is proposed as a qualitative-quantitative single-case experimental study oriented to children aged early to three years with a postnatal hydrocephalus diagnosis who have undergone lavage and cranioplasty and have a shunt in place. The research will aim to develop and validate an intervention program promoting communication skills in the early childhood hydrocephalus child. The research will be conducted intensively over five days a week for six months. The outcome of the research will be the design of a methodology aimed at supporting the child's communication skills with hydrocephalus at an early age, applicable in special education practice.
Morphometric Parameters of the Sphenoid Sinus with Different Types of Pneumatization and Nasal Cavity in Mature Men
Authors: Slavnov A. A. , Devyatirikov D. A. , Putalova I. N. , Suslo A. P. , Sapronova A. N. , Piannikova V. A.
Published: October 2023

The aim of the study was to determine the availability of the relationship between the morphometric dimensions of the sphenoid sinus and the nasal cavity in mature men with different types of pneumatization of sinus shpenoidalis.

Material and methods. A morphometric study of 25 skull cuts of mature men with a wound type of sinus pneumatization performed in the median plane was carried out. A morphometric template and ImageJ version 1.52u program were used to determine the height and longitudinal dimensions of the sinus, the length of the Zuckerkandl line, the thickness of the sinus walls along it, as well as a number of height and longitudinal dimensions of structures forming the walls of the nasal cavity. The Statistica 6.0 program was  used  for  statistical  processing.

Results.  Comparing  the  minimum  height  of  the  sphenoid  sinus  and  the longitudinal  dimensions  of  the  middle  nasal  concha  along  the  attachment  line  and  along  the  free  edge,  the Spearman  correlation  coefficient  has  values  of  0,57  and  0,44,  respectively;  when  comparing  the  longitudinal dimensions of the sinus with the same indicators - 0,53 / 0,56 (for the maximum length of the sinus) and 0,46 / 0,45 (for the minimum); for the Zuckerkandl line, carried out to the anterior and posterior walls of the sinus, and  the height of the piriform aperture - 0,73 and 0,63, respectively.

Conclusion. Basically, regardless of the type of pneumatization of the sinus, its dimensions are not interrelated with the longitudinal and height dimensions of the nasal cavity. A significant moderate positive correlation is observed between the size of the sinus and the length of the middle nasal concha. This implies an interconnected increase in these sizes and, as a result, obtaining the greatest room for maneuver when conducting sinus probing along the Zuckerkandl line in the case of their maximum values.
Visceral Leishmaniasis in Iran: An Update on Epidemiological Features from 2013 to 2022
Authors: Mohebali Mehdi , Edrissian Gholamhossein , Akhoundi Behnaz , Shirzadi Mohammedreza , Hassanpour Gholamreza , Behkar Atefeh , Rassi Yavar , Hajjaran Homa , Keshavarz Hossein , Gouya Mohammad Mehdi , Arshi Shahnam , Zeinali Mohammad , Zarei Zabihollah , Sharifi Iraj , Kakooei Zahra
Published: October 2023

Background: Visceral leishmaniasis (VL) is one of the most important neglected tropical diseases. The zoonotic form of VL is endemic in some areas of Iran. We aimed to determine the status of VL identified in humans and canines in different parts of Iran from 2013 to 2022.
Method: A national representative cross-sectional study was conducted in 10 provinces of Iran, including the national leishmaniasis reference lab. We employed the direct agglutination test (DAT) as a reliable serological method to detect anti-Leishmania infantum antibodies in humans and animal reservoir hosts. Additionally, a narrative literature review was conducted to identify relevant studies on VL seroprevalence in Iran from 2013 to 2023.
Results: The results of 21281 human and 5610 canine serum samples from 2013 to 2022 are reported. Altogether, 448 (2.1%, 95%CI: 2.0-2.3) human serum samples showed anti-L. infantum antibody levels of ≥1:3200. Of these samples, 13716 (64.5%) were collected actively, which showed a seroprevalence of 0.6% (95% CI: 0.5-0.8) and 7565 (35.5%) were collected passively, which showed a seroprevalence of 4.8% (95%CI: 4.3-5.3). Overall, 1035 (20.1%, 95%CI: 19.0-21.2) of 5160 domestic dogs (Canis familiaris) samples showed anti-L. infantum antibody levels of ≥1:320. Northwest (2.8%) and northeast (0.96%) regions had the highest human VL seroprevalence, while northwest (21.5%) and south (14.4%) regions had the highest canine VL seroprevalence.
Conclusion: Zoonotic VL, an endemic parasitic disease, is still present in several different distinct areas across Iran. While human VL cases have shown a declining trend over the last decade, the prevalence of canine VL remains significant.
Molecular Identification and Phylogenetic Analysis of Leishmania major Isolated from Zoonotic Cutaneous Leishmaniasis Foci in Northeast Iran
Authors: Shamsian Seyed Aliakbar , Mirizadeh Hamed , Sangani Ghodratollah Salehi , Zarean Mahdi , Berenji Fariba , Najjari Mohsen , Fata Abdolmajid , Serki Elham , Tahreian Vahideh , Hosseini Farash Bibi Razieh
Published: October 2023

Background: Epidemiological studies, classification and genetic studies of Leishmania species are effective in treatment, control and prevention in endemic areas. We aimed to investigate the genetic diversity and phylogeny of Leishmania in Zoonotic foci located in northeastern Iran using nagt gene for the first time.
Methods: DNA of 100 confirmed positive slides collected from the health centers of Sarkhes, Darghez, Fariman, Esfarayen, and Sabzevar were extracted during 2020-2021. The partial sequence of kDNA was amplified to identify the species. Twenty-five DNA samples were randomly subjected to amplify by nagt gene primes and were sequenced. The sequences were aligned with reference sequences in National Center for Biotechnology Information (NCBI). Then, the genetic similarities of the sequences were checked using Clustalx2.1 software and the phylogenetic tree was drawn by Mega 7 software.
Results: All the positive samples were diagnosed as L. major. Approximately, half of the sequences of species were similar to two reference genes JX103550.1:404-712 L. major Esfahan and KX759012.1:568-807 L. Major Ilam (more than 90% similarity). According to the results of the phylogeny tree, the closest genotype to our study samples was JX103550.1:404-712 L. major Esfahan.
Conclusion: The most causative agent CL in these areas was L. major. The genetic diversity of L. major was high such as other zoonotic foci in Iran. Due to the high similarity of the strains in the study areas with the strains of Isfahan and Ilam, similar control and prevention methods is suggested in these areas.
In Silico Vaccine Design and Expression of the Multi-Component Protein Candidate against the Toxoplasma gondii Parasite from MIC13, GRA1, and SAG1 Antigens
Authors: Hosseininejad Zahra , Daryani Ahmad , Fasihi-Ramandi Mahdi , Asgarian-Omran Hossein , Valadan Reza , Nayeri Tooran , Dodangeh Samira , Sarvi Shahabeddin
Published: October 2023

Background: We aimed to design a B and T cell recombinant protein vaccine of Toxoplasma gondii with in silico approach. MIC13 plays an important role in spreading the parasite in the host body. GRA1 causes the persistence of the parasite in the parasitophorous vacuole. SAG1 plays a role in host-cell adhesion and cell invasion.
Methods: Amino acid positions 73-272 from MIC13, 71-190 from GRA1, and 101-300 from SAG1 were selected and joined with linker A(EAAAK)A. The structures, antigenicity, allergenicity, physicochemical properties, as well as codon optimization and mRNA structure of this recombinant protein called MGS1, were predicted using bioinformatics servers. The designed structure was synthesized and then cloned in pET28a (+) plasmid and transformed into Escherichia coli BL21.
Results: The number of amino acids in this antigen was 555, and its antigenicity was estimated to be 0.6340. SDS-PAGE and Western blotting confirmed gene expression and successful production of the protein with a molecular weight of 59.56kDa. This protein will be used in our future studies as an anti-Toxoplasma vaccine candidate in animal models
Conclusion: In silico methods are efficient for understanding information about proteins, selecting immunogenic epitopes, and finally producing recombinant proteins, as well as reducing the time and cost of vaccine design.
Molecular Epidemiology and Associated Risk Factors of Parasites in Oral Cavity of Children with Malignancies in Western Iran
Authors: Kooshki Fahimeh , Khalaf Amal Khudair , Mahmoudvand Hossein , Baharvand Parastoo , Rouzbahani Faezeh Gandomi , Selahbarzin Behnoush
Published: October 2023

Background: This survey was designed to study the molecular epidemiology and risk factors of Entamoeba gingivalis and Trichomonas tenax in children with underlying malignancies and those on chemotherapy in Lorestan province, West of Iran.
Methods: The present cross-sectional descriptive study was performed on children who suffering from different types of malignancies or receiving treatment by chemotherapy referring to oncology section of hospitals of Lorestan Province, Iran during May 2021 to April 2022. The frequency of oral cavity protozoa was investigated using microscopic and conventional polymerase chain reaction (PCR).
Results: E. gingivalis and T. tenax parasites were found in 23 (25.5%) by microscopic method and 28 (31.1%) using PCR in children with malignancy. Among positive samples, 20 (71.4%) were infected with E. gingivalis; whereas 8 (28.6%) of the participants were positive for T. tenax. In the multivariate model, living in rural regions (OR= 3.437; 95% CI= 1.22-9.63; p=0.019) and using mouthwash (OR= 0.082; 95% CI= 0.018-0.37; p<0.001) were significantly related with the frequency of oral cavity parasites.
Conclusion: Our results showed the high frequency of oral cavity parasites in children who suffering malignancies or receiving treatment by chemotherapy in Lorestan province, Iran. The awareness of the main risk factors for oral cavity parasites particularly using mouthwash is necessary in improving public and oral health strategies in children with cancer. Consequently, oncologist and dental practitioners must be aware to identify and manage oral health concerns in in children who suffering from different types of malignancies to prevent the oral diseases and infections.
The Accuracy of Diagnosis and Genotyping of Leishmania Species Based on Spliced Leader Mini-Exon Gene by Nuclear Magnetic Resonance and Sequencing Assays
Authors: Khorram Mahyar , Masjedi Heidar , Tabrizi Fatemeh , Rezaei Mitra , Tabarsi Payam , Marjani Majid , Pourabdoullah Mihan , Sheikholeslami Fatemeh-Maryam
Published: October 2023

Background: We aimed to evaluate the accuracy of genotyping of Leishmania species by the spliced leader mini-exon gene.
Methods: Suspected leishmaniasis patients, referred to Masieh Daneshvary Hospital, Tehran, Iran were included from May 2017 to September 2021. The Leishmania species were genotyped by PCR-RFLP based on the SL mini-exon gene and the ITS1 region of SSU-rRNA gene and compared with the sequencing results. The expressed metabolites of metacyclic promastigotes were evaluated by Proton nuclear magnetic resonance (1H-NMR).
Results: Out of 66 suspected cases, 36 (54.4%) were positive for Leishmania species based on the PCR assays. In 21 (31.8%) cases, promastigotes grew on culture tubes. Based on the RFLP of SL RNA profile, 13 (19.7%) L. tropica, 9 (13.6%) L. major, 3 (4.5%) L. infantum, and 8 (12.1%) C. fasciculata isolates, isolated from culture media, were identified; however, 3 (4.5%) cases were unidentifiable due to the low number of parasites. Seventeen metabolites were expressed by the metacyclic forms of L. major, L. tropica and C. fasciculata isolates. The top differential metabolites expressed more in C. fasciculata were FAD, p-Methoxybenzyl alcohol and S-b-G-5, 5-G-b-S (A = CH2) (P<0.005) whereas Veratryl glycerols and D-(+)-Mannose were significantly increased in L. major and Betulin, L-Tyrosine in L. tropica (P<0.01).
Conclusion: The invaluable techniques such as sequencing and 1H-NMR confirmed the results of genotyping of Leishmania species based on the SL mini-exon gene.  SL mini exon gene can be used as a diagnostic tool to differentiate various Leishmania genotypes and detect contamination of culture media with C. fasciculata.
Preliminary Information of Iranian Lizard Leishmania Pro-mastigote Transcriptome Sequencing by Next -Generation Sequencing (NGS) Method
Authors: Ehya Farveh , Kalantari Sima , Bandehpour Mojgan , Kazemi Bahram
Published: October 2023

Background: A lizard Leishmania has been isolated from a lizard (Agama agilis) in Iran. Its genome sequence has not been determined, so far.
Methods: The study was done at Shahid Beheshti University of Medical Sciences, Tehran, Iran in 2017-2023. Leishmania promastigotes were cultured in RPMI1640 culture medium and collected at logarithmic phase by centrigugation. Parasite RNA was extracted by the Qiagene standard kit and its quantity and quality was determined and sequenced by NGS method with Illumina PE machine at BGI Company (China).
Results: The number of 8316 mRNA, 83 tRNA, 63 rRNA, 83 ncRNA, 5 snRNA, 1039 snoRNA, 36 region, and 3 repeat regions, 8343 CDS, 9597 Exon and 9292 Genes were identified in promastigote of Iranian lizard Leishmania.
Conclusion: Genomic elements of Iranian lizards Leishmania (with unique characteristics) were determined and identified by NGS system.
Splenic Infarction Secondary to COVID-19 and Malaria Co-Infection: A Case Report
Authors: Karakök Taliha
Published: October 2023

Splenic infarction is a rare complication of both malaria and COVID-19. We report a splenic infarction case due to COVID-19 and malaria co-infection. A 35‑year‑old male with no known chronical disease tested positive for both COVID-19 and malaria in Turkey in 2022. Oral artemether and lumefantrine treatment was started. On the third day of the treatment, he complained about a severe left upper quadrant pain. A repeated abdominal CT showed splenomegaly and 8 cm diameter hypodense areas throughout the spleen consistent with splenic infarction. The patient was discharged with low molecular weight heparin. A rare complication that can be seen in both diseases developed a more rigorous recommendation for anticoagulant therapy is needed for co-infections of COVID-19 with diseases that may present similar thrombotic complications.
Genetic Detection of Amoebic Meningoencephalitis Causing by Naegleria Fowleri in Iraq: A Case Report
Authors: Baqer Noor Nihad , Mohammed Ahmed Salih , A.AL-Aboody Bassad , Ismail Abdullah Musaied
Published: October 2023

We diagnosed a case report of amoebic meningoencephalitis by Naegleria fowleri. This case represented the first recording in Iraq where it was not recording previously. This case was diagnosed after the death of an 18-year-old girl patient who lived in a rural area of Mosul in Iraq. Genetics detection of N. fowleri showed PCR product was 183bp for 18S rRNA gene. It was registered as the first recording of Iraqi isolate N. fowleri in GenBank with accession number OP380864.1. It is necessary to examine microscopically the cerebral spinal fluid (CSF) to observe the amoeba stages and exclude the bacterial causative. Rapid diagnosis may help in the treatment of amoebic meningoencephalitis. In addition, genetic identification can diagnose amoeba. Avoiding swimming or using freshwater contributes to prevent amoebic meningoencephalitis infection.