bluuebunny/crossref_metadata_2025 huggingface dataset:
Enfance, martyre et mission dans L’Histoire des martyrs du Japon de Nicolas Trigault (1624)
Authors: Gatelier Mathis
Published: April 2024

This article analyses a still understudied figure that is present in martyrological accounts of the Early Modern Period: the child martyr which is an intriguing and important character in Catholic propaganda during the wars of religion that shook Europe. We will see how a Jesuit missionary uses this character in his account of the Christian mission in Japan. Nicolas Trigault (1577–1628), in his work L’Histoire des martyrs du Japon (The History of the Martyrs of Japan) takes up a long Christian martyrological tradition while anchoring it in a context of cultural exchanges between Europe and Japan. Using various biblical narratives (whether the Passions of Christ or the martyrdom of the Maccabees) as a point of comparison with these Japanese martyrs, Trigault places these Christians, so far removed from his target audience, in a Catholic community that extends over a long period of time and a vast geographical territory. In this use of the martyrological narrative, the death of the children proves to be a powerful argument. As exceptional figures of martyrdom, they act as witnesses to the level of faith of a community, the sacrifice of the children being the ultimate demonstration of its constancy. However, the figure of the martyred child also comes into conflict with the figure of the morally crippled child, testifying to the ambiguity that European culture and the Christian religion have with this period of life. These stories, later exported to Europe, are used to edify both the youngest children, urging them to imitate their Japanese counterparts, and the parents, presenting an ideal imagery of the Christian family.
Research on teaching quality evaluation of higher vocational architecture majors based on enterprise platform with spherical fuzzy MAGDM
Authors: Yang Cheng , Liu Jing
Published: April 2024

Teaching quality evaluation is a process of evaluating the teaching quality of architectural majors. It can not only evaluate the teaching level of teachers, but also evaluate the learning effectiveness of students. Therefore, this study designs a teaching quality evaluation system for architecture majors based on fuzzy environment, in order to provide direction guidance for effectively evaluating the teaching quality of architecture majors by using this research. The teaching quality evaluation of higher vocational architecture majors based on enterprise platform is a multiple-attribute group decision-making (MAGDM). The spherical fuzzy sets (SFSs) provide more free space for decision makers to portray uncertain information during the teaching quality evaluation of higher vocational architecture majors based on enterprise platform. Therefore, this study expands the partitioned Maclaurin symmetric mean operator and induced ordered weighted average operator to SFSs based on the power average technique and construct induced spherical fuzzy power partitioned MSM (I-SFPPMSM) technique. Subsequently, a novel MAGDM method is put forward based on I-SFPPMSM technique and spherical fuzzy number weighted geometric technique under SFSs. Finally, a numerical example for teaching quality evaluation of higher vocational architecture majors based on enterprise platform is employed to verify the put forward method, and comparative analysis with some existing techniques to testy the validity and superiority of the I-SFPPMSM technique.
DO seniors and IMGs have lower match probabilities than MD seniors after adjusting for specialty choice and USMLE Step 1 score
Authors: Nikolla Dhimitri A. , Bowers Kaitlin M. , Smith Brittany , Elsayed Christina L. , Daniels Abigail , Sandoval Thomas , Hitchman Kyle J. , Asar Irtaza , Kolacz Dillon C. , Mudrakola Vishnu
Published: April 2024

Context

It is unknown if US residency applicants of different educational backgrounds (US allopathic [MD], Doctor of Osteopathic Medicine [DO], and international medical graduates [IMG]) but comparable academic performance have similar match success.

Objectives

Our objective was to compare match probabilities between applicant types after adjusting for specialty choice and United States Medical Licensing Examination (USMLE) Step 1 scores.

Methods

We performed a secondary analysis of published data in National Resident Matching Program (NRMP) reports from 2016, 2018, 2020, and 2022 for US MD seniors, DO seniors, and IMGs (US citizens and non-US citizens). We examined the 10 specialties with the most available spots in 2022. Average marginal effects from a multiple variable logistic regression model were utilized to estimate each non-MD senior applicant type’s probability of matching into their preferred specialty compared to MD seniors adjusting for specialty choice, Step 1 score, and match year.

Results

Each non-MD applicant type had a lower adjusted percent difference in matching to their preferred specialty than MD seniors, −7.1 % (95 % confidence interval [CI], −11.3 to −2.9) for DO seniors, −45.6 % (−50.6 to −40.5) for US IMGs, and −56.6 % (−61.5 to −51.6) for non-US IMGs. Similarly, each non-MD applicant type had a lower adjusted percent difference in matching than MD seniors across almost all Step 1 score ranges, except for DO seniors with Step 1 scores <200 (−2.0 % [−9.5 to 5.5]).

Conclusions

After adjusting for specialty choice, Step 1 score, and match year, non-US MD applicants had lower probabilities of matching into their preferred specialties than their US MD colleagues.
Left atrial appendage closure in conjunction with radiofrequency ablation: Effects on left atrial functioning in patients with paroxysmal atrial fibrillation
Authors: Lv Jing , Wang Rui , Yang Jing , You Ling , Yang Chao , Zhang Yan , Liu Qian , Yin Lei , Liu Jin-ting , Xie Rui-qin
Published: April 2024

Objective

In the present study, we investigated the impact of left atrial appendage closure (LAAC) following catheter ablation (CA) on the left atrial structure and functioning of patients with paroxysmal atrial fibrillation (AF).

Methods

Patients with paroxysmal AF were enrolled in this single-center prospective cohort study between April 2015 and July 2021; 353 patients received CA alone, while 93 patients received CA in combination with Watchman LAAC. We used age, gender, CHA2DS2-VASc, and HAS-BLED scores as well as other demographic variables to perform propensity score matching. Patients with paroxysmal AF were randomly assigned to the CA combined with Watchman LAAC group (combined treatment group) and the simple CA group, with 89 patients in each group. The left atrial structure, reserve, ventricular diastole, and pump functions and their changes in patients were assessed using routine Doppler echocardiography and 2D speckle tracking echocardiography over the course of a 1-year follow-up.

Results

At 1-week follow-up, the reserve, ventricular diastole, and pump functions of the left atrium (LA) increased in both groups; these functions were gradually restored at the 1- to 3-month follow-up; they were close to or returned to their pre-operative levels at the 3-month follow-up; and no significant differences were found compared with the pre-operative levels at the 12-month follow-up. In the first 3 months, the reserve (Ƹ, SRs) and pump functions (SRa) in the combined treatment group decreased significantly when compared with the simple CA group, and the differences were statistically significant.

Conclusion

Patients with paroxysmal AF may experience a short term, partial effect of LAAC on LA reserve and pump functions, which are gradually restored and the effect disappears by 12 months.
Optically driven plasmons in graphene/hBN van der Waals heterostructures: simulating s-SNOM measurements
Authors: Golenić Neven , de Gironcoli Stefano , Despoja Vito
Published: April 2024

Converting transverse photons into longitudinal two-dimensional plasmon-–polaritons (2D-PP) and vice versa presents a significant challenge within the fields of photonics and plasmonics. Therefore, understanding the mechanism which increases the photon – 2D-PP conversion efficiency could significantly contribute to those efforts. In this study, we theoretically examine how efficiently incident radiation, when scattered by a silver spherical nanoparticle (Ag-NP), can be transformed into 2D-PP within van der Waals (vdW) heterostructures composed of hexagonal boron nitride and graphene (hBN/Gr composites). We show that the Dirac plasmon (DP) excitation efficiency depends on the Ag-NP radius as R
3, and decreases exponentially with Ag-NP height h, so that for a certain Ag-NP geometry up to 25 % of the incident electrical field is channeled into the DP. We demonstrate that the linear plasmons (LPs) excitation efficiency can be manipulated by changing the graphene–graphene distance Δ (or hBN thickness) or by changing the number of graphene layers N. By increasing Δ and/or N the LPs move towards smaller wave vectors Q and become accessible by the Ag-NP dipole field, so that for N ≥ 5 the excitation of more than one LP is possible. These results are supported by recent scattering-type scanning near-field optical microscopy (s-SNOM) measurements. Furthermore, we show that Ag-NPs with specific parameters preferentially hybridizes with DPs of a particular wavelength λ

D
, facilitating selective excitation of DPs. The obtained tuning possibilities could have a significant impact on applied plasmonics, photonics or optoelectronics.
Optical trapping and manipulating with a transmissive and polarization-insensitive metalens
Authors: Yang Dongni , Zhang Jianchao , Zhang Pengshuai , Liang Haowen , Ma Jie , Li Juntao , Wang Xue-Hua
Published: April 2024

Trapping and manipulating micro-objects and achieving high-precision measurements of tiny forces and displacements are of paramount importance in both physical and biological research. While conventional optical tweezers rely on tightly focused beams generated by bulky microscope systems, the emergence of flat lenses, particularly metalenses, has revolutionized miniature optical tweezers applications. In contrast to traditional objectives, the metalenses can be seamlessly integrated into sample chambers, facilitating flat-optics-based light manipulation. In this study, we propose an experimentally realized transmissive and polarization-insensitive water-immersion metalens, constructed using adaptive nano-antennas. This metalens boasts an ultra-high numerical aperture of 1.28 and achieves a remarkable focusing efficiency of approximately 50 % at a wavelength of 532 nm. Employing this metalens, we successfully demonstrate stable optical trapping, achieving lateral trapping stiffness exceeding 500 pN/(μm W). This stiffness magnitude aligns with that of conventional objectives and surpasses the performance of previously reported flat lenses. Furthermore, our bead steering experiment showcases a lateral manipulation range exceeding 2 μm, including a region of around 0.5 μm exhibiting minimal changes in stiffness for smoothly optical manipulation. We believe that this metalens paves the way for flat-optics-based optical tweezers, simplifying and enhancing optical trapping and manipulation processes, attributing ease of use, reliability, high performance, and compatibility with prevalent optical tweezers applications, including single-molecule and single-cell experiments.
Tunable on-chip optical traps for levitating particles based on single-layer metasurface
Authors: Sun Chuang , Pi Hailong , Kiang Kian Shen , Georgescu Tiberius S. , Ou Jun-Yu , Ulbricht Hendrik , Yan Jize
Published: April 2024

Optically levitated multiple nanoparticles have emerged as a platform for studying complex fundamental physics such as non-equilibrium phenomena, quantum entanglement, and light–matter interaction, which could be applied for sensing weak forces and torques with high sensitivity and accuracy. An optical trapping landscape of increased complexity is needed to engineer the interaction between levitated particles beyond the single harmonic trap. However, existing platforms based on spatial light modulators for studying interactions between levitated particles suffered from low efficiency, instability at focal points, the complexity of optical systems, and the scalability for sensing applications. Here, we experimentally demonstrated that a metasurface which forms two diffraction-limited focal points with a high numerical aperture (∼0.9) and high efficiency (31 %) can generate tunable optical potential wells without any intensity fluctuations. A bistable potential and double potential wells were observed in the experiment by varying the focal points’ distance, and two nanoparticles were levitated in double potential wells for hours, which could be used for investigating the levitated particles’ nonlinear dynamics, thermal dynamics and optical binding. This would pave the way for scaling the number of levitated optomechanical devices or realizing paralleled levitated sensors.
Enhancing thermal stability of Nd:GGG WGM microdisk lasers via silica integration
Authors: Li Huiqi , Wang Zhaocong , Wang Lei , Tan Yang , Chen Feng
Published: April 2024

Whispering gallery mode (WGM) resonators, as an integral component of integrated photonics, have attracted considerable attention due to their high Q factor, small footprint, and small mode volume, making them widely applied as microlasers. In this work, Nd:GGG crystal was prepared into a Nd:GGG film with thickness of 1.8 μm through ion implantation-enhanced etching (IIEE) technique, and subsequently, the Nd:GGG film was partened by focused ion beam (FIB) technology to generate a microdisk with diameter of 20 μm. For high-power microcavity lasers, heat generation during laser operation was inevitable. We placed the microdisk on a silica holder and a silica wafer, respectively. The microdisk placed on the silica holder and silica wafer exhibited laser thresholds of 32 μW and 17 μW, respectively. Moreover, due to different heat dissipation conditions, the microdisk placed on the silica holder exhibited a mode shift of 0.13 nm/mW, while the microdisk placed on the silica wafer showed a more stable laser output state with a mode shift of 0.02626 nm/mW.
Crystal structure of methyl-1-(p-tolyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylate, C20H20N2O2
Authors: Gao Yanrong , Dang Xiaolin , Wang Yanjiao , Liu Bin , Tang Wenqiang
Published: April 2024

C20H20N2O2, monoclinic, P21 (no. 4), a = 8.3293(4) Å, b = 11.3947(5) Å, c = 8.9536(4) Å, β = 108.489(2)°, V = 805.92(6) Å3, Z = 2, Rgt
(F) = 0.0495, wRref
(F
2) = 0.1094, T = 150 K.
Skin conductance algesimeter is unreliable during sudden perioperative temperature increases
Authors: Kongsgaard Ulf E. , Menchini Robin Johansen , Larsen Stein Gunnar , Juul-Hansen Knut Erling
Published: April 2024

Objectives

Pain assessment in anesthetized and non-communicative patients remains a challenge. Clinical signs such as tachycardia, hypertension, sweat and tears, have a low specificity for pain and should therefore ideally be replaced by more specific monitoring techniques. Skin conductance variability has been demonstrated to establish a patients’ sensitivity to pain, but may be influenced by temperature changes that leads to profuse sweating. The aim of this pilot study was to test skin conductance changes during sudden temperature changes due to hyperthermic intraperitoneal chemotherapy (HIPEC) perfusation.

Methods

We investigated skin conductance algesimeter (SCA) in ten consecutive patients undergoing cytoreductive surgery and HIPEC. Results from the SCA was compared to other standard physiological variables at seven time points during the surgical procedure, in particular during the period with hyperthermic intraabdominal perfusion leading to an increase in the patients core temperature.

Results

Nine out of ten patients had an increase in the SCA measurements during the HIPEC phase correlating the increase in temperature.

Conclusion

SCA is unreliable to detect increased pain sensation during sudden perioperative temperature changes in adult patients.
Malaysia in 2023
Authors: Weiss Meredith L.
Published: April 2024

Prime minister Anwar Ibrahim steered his cobbled-together government through economic and sociocultural challenges in 2023, emerging stable but spooked. State-level elections in August sustained each party’s roster of states, but with declining margins for Anwar’s coalition. Fiscal pressures—high debt, declining revenues, rising cost of living, and a persistently weak currency—constrained room for maneuver, while state-level and societal cultural contests tested Malaysia’s multiracial, multireligious tolerance.
DEVELOPMENT OF AN ENERGY-EFFICIENT AUTOMATIC CONTROL SYSTEM OF MOBILE INDUSTRIAL ROBOT
Authors:   Odesa Polytechnic National University, Shevchuk O. S. , Voytenko V. A. ,   Odessa Polytechnic National University, Vodichev V. A. ,   Odesa Polytechnic National University, Kalinin A. G. ,   Odesa Polytechnic National University
Published: April 2024

Abstract. The use of neural networks in automatic control systems makes it possible to increase their compliance with the assigned tasks. Such automatic control systems are able not only to use the general control methods, but also offer their algorithmic approaches to solving the tasks related to the problem of identifying the parameters of the control object. In the article, adaptive control systems and control systems using neural networks are considered. An analysis of recent research in this direction has been conducted. A concept has been proposed for the development of an energy-efficient intelligent automatic control system for a multi-motor electric drive of a mobile industrial robot. Keywords: automatic control system, mobile industrial robot, nonlinearity, energy-efficiency, uncertainty, adaptability, neural network, mechatronic module.
MODEL AND METHOD FOR ANALYZING THE OPERABILITY OF THE COUNTRY'S ELECTRIC POWER SYSTEM UNDER NON-PROJECTED DISTURBANCES
Authors:   Scientific research center of the Armed Forces of Ukraine “State Oceanarium” of the Institute of the Naval Forces, Maksymov M. V. , Kryvda V. I. ,   Odessa Polytechnic National University, Suvorov V. O. ,   Odesa Polytechnic National University
Published: April 2024

Abstract. Information and simulation models are important tools in the modern world for analyzing, designing, and optimizing various systems. One effective approach to their construction is the use of graph theory. In this article, we will examine the fundamental principles of constructing an information model using graphs and the method for analyzing the operability of this model under non-projected disturbances. In amidst increasing demands for reliability in the energy sector, the concept of developing an energy system in the form of a layered graph is becoming increasingly relevant and promising. A layered graph simulation model can provide an effective tool for optimizing energy supply and ensuring the stability and reliability of the system. Using a layered graph, it is possible to visualize the hierarchy of different energy sources, including renewable sources, traditional fuel types, and energy-efficient technologies. This will facilitate understanding the interaction between various components of the system and allow for the improvement of their integration. Keywords: electric power system, operability of the electric power system, assessment of the operability of the power supply system, non-project disturbances in the electric power system, generation, transformer substations, electricity consumers.
SOLVING THE PROBLEM OF ONE-DIMENSIONAL CUTTING ON THE BASIS OF GENETIC ALGORITHM
Authors:   Odesa Polytechnic National University, Davydov Valentin , Tarakhtiy Olga S. ,   Odessa Polytechnic National University
Published: April 2024

Abstract. The process of synthesis of algorithm for solving the problem of one-dimensional cutting of furniture profile is considered. The following are shown: the process of designing the necessary types of data, selection of criteria and synthesis of the target function, synthesis of the algorithm for solution search on the basis of genetic algorithm elements. Keywords: One-dimensional cutting problem, genetic algorithm.
MODEL AND METHOD OF DECISION-MAKING RULES FOR THE FORMATION OF THE STRUCTURE OF TECHNICAL EQUIPMENT IN PROCESSES OF THERMAL DESTRUCTION OF MSW IN THE NORMATION OF ACID GASES EMISSIONS
Authors:   National University ", Maksymova O. B. ,   Odesa Maritime Academy", Lysiuk H. P. ,   Odessa Polytechnic National University, Zhanko К. О. ,   Odesa Polytechnic National University, Bessarab V. P. ,   Odesa Polytechnic National University
Published: April 2024

Abstract. A simulation model for the purification process of classified municipal solid waste (MSW) has been developed, taking into account the consumption of resources to bring the resulting carbon-hydrogen gases from the classified MSW of the main group to an environmentally acceptable state, which will ensure that the impurities of groups that form acid gases are taken into account for various conditions of processing by thermal destruction methods. Decision-making rules for the formation of the structure of technical means for the purpose of processing solid waste using thermal destruction. A comprehensive technological scheme of the thermal recycling method is presented, ensuring compliance with environmental conditions for emissions into the environment when using secondary energy resources obtained from solid waste. Key words: municipal solid waste, thermal destruction, thermal utilization, pyrolysis, incineration, acid gases.
INTELLIGENT TIME SERIES DATA ANALYSIS OF CRYPTOCURRENCY MARKET DYNAMICS BASED ON OHLCV DATASET AND MOMENTUM TECHNICAL INDICATORS
Authors:   Odesa Polytechnic National University, Uzun I. S. , Lobachev M. V. ,   Odessa Polytechnic National University
Published: April 2024

Abstract. This article presents an analysis of the historical dynamics of the cryptocurrency market based on time series data using the OHLCV dataset. The study presents the results of calculations of the main cryptocurrency market momentum technical indicators. Using intelligent computational methods, the paper assesses patterns and trends in the data of major cryptocurrencies. The study emphasizes the importance of technical analysis in understanding the volatile landscape of digital currencies. Key words: time-series, data analysis, cryptocurrency market, momentum indicators, technical analysis indicators, OHLCV.
Aromatherapy: an alternative treatment for migraine headaches
Authors: Penhollow Tina M , Mielke Alexandra C
Published: April 2024

Neurological disorders are recognized as one of the leading causes of death and disability worldwide. Migraines are a neurological disorder that is often accompanied by symptoms such as pain, light and sound sensitivity, nausea, vomiting, and changes in vision. There are many challenges to managing episodic and chronic migraines. There are several non-modifiable and modifiable risk factors associated with migraine onset. Pharmacological management has been shown to be effective. Research has also shown that aromatherapy can have a positive impact on preventing and managing migraine headaches. The purpose of this mini review is to provide current data on migraines and to offer options beyond prescribed pharmaceutical medication to alleviate symptoms of this disorder. It is important to offer alternative preventative solutions to manage migraine disorders.
To attract a moth: Wind tunnel and field testing of plant odor and light stimuli and their combination for Ostrinia nubilalis
Authors: Zhukovskaya Marianna I. , Grushevaya Inna V. , Miltsen Alexander A. , Selitskaya Oksana G. , Shchenikova Anna V. , Frolov Andrei N. , Tóth Miklós
Published: April 2024

The European corn borer, Ostrinia nubilalis (Hubner), relies on multimodal sensory information to find food, mates, mating and ovipositional grounds. Successful phytosanitary monitoring demands for the bait for the field traps to obtain the most reliable representation of pest abundance. Attraction to light and blend of key components of host plant odor, was tested both in the laboratory and field conditions. Ultraviolet light, which was the most effective in the wind tunnel experiments, was further tested in the field alone and in combination with bisexual lure. Bisexual lure, being attractive in the lab, as well as in the field, did not improve responses to ultraviolet in both experimental designs. All three baits attracted significantly more females than males in the field. Wind tunnel experiments revealed that ultraviolet elicited the shortest response latencies either alone or paired with the odor bait. The lack of synergistic effect between attractive light and odor stimuli is an important issue for pest monitoring. The possible reasons for the observed lack of synergy are the hierarchy of behavioral responses to different stimuli or the intensities of both stimuli are critically important for attractivity of combined stimulus and differ from separately presented ones.
Idegsebészeti posztoperatív őrzőben kezelt idős betegek SARS-CoV-2 és Clostridioides difficile kombinált fertőzése
Authors: Oláh Csaba Zsolt , Czakó Judit , Godó Zoltán Attila , Farkas Mária , Papp Miklós , Czabajszki Máté
Published: April 2024

A COVID–19-pandémia során fellépő Clostridioides difficile
fertőzés incidenciájával kapcsolatban egymással ellentétes eredmények ismertek:
számos tanulmány szerint növekedett, míg más tanulmányok szerint csökkent. A
második COVID–19-hullám tetőfokán idegsebészeti posztoperatív őrzőnkben 11,
intenzív ellátást igénylő beteget kezeltünk. A 11 betegből 7 COVID–19-pozitív
lett, és közülük 4 betegnél még C. difficile fertőzés is
kialakult. A 4-ből 2 beteget elveszítettünk. Bár megfigyeléseinket kevés beteg
ellátása során gyűjtöttük, úgy ítéljük meg, hogy súlyos állapotú betegeknél a
SARS-CoV-2 és a C. difficile együttes fertőzése
többletkockázatot jelent. A COVID–19-ben alkalmazott, széles spektrumú
szisztémás antibiotikumok használata növelheti a C. difficile
infekció rizikóját. Jól átgondolt infekciókontroll, a megfelelő higiéné
betartása, az alkoholos kézfertőtlenítők mellett a rendszeres szappanos
kézmosások mérsékelhetik a nosocomialis C. difficile fertőzések
számát. Orv Hetil. 2024; 165(12): 464–469.
Lehetne-e csökkenteni az enyhe koponyasérültek sürgősségi koponya-CT-vizsgálatainak számát?
Authors: Viczei Alexandra , Lapis István , Kiss Gergő , Solti Árpád , Szeifert György
Published: April 2024

Bevezetés: A koponya- és agysérüléseket (craniocerebralis
traumák) nemzetközileg elfogadott standardok alapján osztályozzuk, gyakoriságuk
és megoszlásuk országonként eltérő. Magyarországon 100 000 lakosra évente
átlagosan 2000 koponyasérülés jut, s ezeknek legfeljebb a negyede jár kórházi
felvétellel. Az elrendelt sürgős CT-vizsgálatok száma az Egyesült Államokban és
hazánkban is a duplájára nőtt az elmúlt 20–30 évben. A készült koponya-CT-k
közel 90%-a bizonyult negatívnak. Az enyhe fejsérülést vagy agyrázkódást
szenvedett betegek rövid ideig tartó eszméletvesztésről, átmeneti fejfájásról,
retrograd amnesiáról vagy dezorientációról számolnak be, a GCS (Glasgow-i Coma
Skála) szerinti 13–15-ös értékű tudatállapot mellett. Fizikális vizsgálat után
ezek a betegek sürgősségi osztályon való megfigyelést követően elbocsáthatók
lehetnek, mivel az eddigi gyakorlat alapján az elvégzett koponya-CT-vizsgálat
kóros eltéréseket nem igazolt. Célkitűzés: A CT nem hatékony
használata jelentősen növeli a betegek felesleges sugárterhelését, valamint az
egészségügyi ellátás költségeit is. Ezek mérséklésére többféle, külföldön már
jól bevált szabályozási rendszer van érvényben, amelyek azonban hazánkban még
nem váltak rutinszerűen alkalmazhatóvá. Saját beteganyagunk adatainak
áttekintésével azt vizsgáltuk, hogy szükséges volt-e minden esetben a
koponya-CT-vizsgálat. Módszer: Megvizsgáltuk a Békés Vármegyei
Központi Kórház Sürgősségi Osztályán jelentkező koponyasérült betegek ellátási
gyakorlatát. Eredmények: Retrospektív elemzésünk alapján a
Kanadai Koponya CT Szabályt alkalmazva a sürgős koponya-CT-vizsgálatok száma kb.
70%-kal lett volna csökkenthető. Következtetés: A külföldön már
alkalmazott standard rendszerek hazai használatával lehetőség nyílna az enyhe
fejsérültek ellátási hatékonyságának javítására a magyarországi sürgősségi
betegellátó osztályokon is. Orv Hetil. 2024; 165(14): 538–544.
Az első hazai tapasztalatok összegzése kromoszomális microarray-analízis és teljesexom-szekvenálás módszerekkel a magzati diagnosztikában
Authors: Pikó Henriett , Illés Anett , Nagy Sándor , Beke Artúr , Árvai Kristóf , Elekes Tibor , Horváth Emese , Ferenczy Miklós , Mosonyi Péter , Lukács Valéria , Klujber Valéria , Török Olga , Kiss Zsuzsanna , Tardy Erika , Tidrenczel Zsolt , Tobiás Bálint , Balla Bernadett , Lakatos Péter , Kósa János , Takács István
Published: April 2024

Bevezetés: Az elmúlt évtized egyik jelentős technológiai
újdonsága az ún. ’high-throughput’ molekuláris genetikai vizsgálati módszerek –
mint a kromoszomális microarray-analízis (chromosomal microarray analysis, CMA)
és a teljesexom-szekvenálás (whole-exome sequencing, WES) – elterjedése a
praenatalis diagnosztikában. Célkitűzés: Az elmúlt 5 évben
munkacsoportunk több mint 252 praenatalis vizsgálatot végzett hazai
laboratóriumi háttérrel, amelyek indikációját különböző súlyosságú strukturális
magzati ultrahangeltérések képezték. A klasszikus citogenetikai vizsgálatok
eredményétől függően végeztük el a nagy felbontású CMA- és WES-analíziseket a
praenatalis diagnosztika érdekében. Módszer: A
CMA-vizsgálatokat a „GeneChip System 3000 Instrument” platformmal végeztük az
SNP-alapú komparatív hibridizálás módszerével. Az általunk elvégzett
újgenerációs szekvenálás során a teljes humán exom szekvenciájának meghatározása
IonTorrent és Illumina platformokkal történt. Eredmények:
Összesen 252 magzati CMA-vizsgálatot végeztünk, és 42%-ban mutattunk ki
valamilyen hiányt vagy többletet, ebből 22%-ban igazoltunk kóros eltérést. 42
esetben végeztünk WES-t, amelyből 9 esetben (21,4%) azonosítottunk kóros
eltérést az öröklésmenetet támogató, a magzati fenotípussal feltételezhetően
összefüggésben lévő, a ClinVar adatbázis vagy az ACMG-klasszifikáció alapján.
Megbeszélés: Tekintettel arra, hogy a magzati fenotípus
értékelése közvetett, a praenatalis CMA- és WES-elemzésnek elsősorban a magzati
ultrahangvizsgálat során azonosítható strukturális anomáliákkal összefüggő
génekre, kromoszomális régiókra kell korlátozódnia. A szülők vizsgálata mind a
CMA-, mind a WES-analízisek során kiemelt jelentőséggel bír, főleg azokban az
esetekben, amelyeknél a kapott eltérés nem hozható egyértelmű összefüggésbe az
ultrahangeltérésekkel. Következtetés: Fontos meghatározni
azokat a paramétereket, amelyek alapján a magzati mintában talált
kópiaszám-eltéréseket és WES-vizsgálattal igazolt variánsokat a leletben
közöljük (figyelembe véve a nemzetközi ajánlásokat). Ezek alapján a praenatalis
klinikai genetikai tanácsadáskor sokkal használhatóbb információk adhatók. Orv
Hetil. 2024; 165(14): 523–530.
Patients Satisfaction with the Chronic Disease Management Program in Indonesia Using the Importance-Performance Matrix
Authors: Kusumawardana Ramza Aurum , Sunjaya Deni Kurniadi , Gondodiputro Sharon , Raksanagara Ardini Saptaningsih , Ardisasmita Mulya Nurmansyah , Widjajakusuma Anggraini
Published: April 2024

Background: Indonesia still has a high prevalence of hypertension and diabetes mellitus. On the other hand, essential health services were disrupted during the COVID-19 pandemic. Hence, the quality of service still needs to be prioritized. The government also obliges the government-owned primary healthcare facilities (Pusat Kesehatan Masyarakat, Puskesmas) to conduct customer satisfaction surveys to evaluate service quality. This study was conducted to analyze patients’ satisfaction with the chronic disease management program (Program Pengelolaan Penyakit Kronis, Prolanis) provided by Puskesmas in Bogor City.Methods: Quantitative research with a survey approach using the CSI-29 questionnaire was conducted from October to November 2021 on 104 Prolanis participants from 6 Puskesmas in Bogor City, West Java, Indonesia. The variables were 9 dimensions of satisfaction based on the CSI-29 questionnaire. Data was transformed using the Rasch model and analyzed using the Importance-Performance Matrix (IPM).Results: Of the 104 participants, there were 78 (75%) were satisfied with the Prolanis services provided by the Puskesmas. The IPM analysis showed that the dimensions of requirements, procedures, costs, type of service products, and attitudes of health workers had low expectations and perceived performance level.Conclusions: Most of the Prolanis participants were satisfied with the Prolanis services provided by the Puskesmas in Bogor City.
Turmeric and Mangosteen Extract Modulate Autophagy Gene Expression in High-Fat Diet-Induced Rats
Authors: Gunadi Julia Windi , Jasaputra Diana Krisanti , Pangestuti Balqist Sriprobo , Wahyudianigsih Roro , Lesmana Ronny
Published: April 2024

Background: High-fat diet (HFD) increases the risk of obesity, metabolic syndrome, coronary artery disease, and chronic kidney disease, resulting in lipotoxicity. Turmeric and mangosteen are two ingredients mostly used in Indonesian food, and are known for their antihyperlipidemic and antioxidant effects. The aim of this study was to explore the effect of turmeric and mangosteen on autophagy gene expression in HFD-induced kidneys in rats model.Methods: The study was an experimental study, including 25 male Wistar rats aged 8 weeks, divided into 5 groups with a completely randomized design; group with a standard diet as negative control group, the group with a high-fat diet as a positive control group, and the HFD groups with turmeric or mangosteen or fenofibrate. The study was conducted in Maranatha Biomedical Research Laboratory from January to November 2022. Autophagy gene expression (LC3, p62) was measured along with the histopathological scoring to observe necrosis, inflammation, and fat degeneration state. Data was analyzed using One Way ANOVA or Kruskal Wallis and post hoc Least Significant Difference or Mann Whitney.Results: There were significant differences in inflammation in groups treated with mangosteen (p=0.007); in fat degeneration in groups treated with mangosteen and fenofibrate (p=0.007). Furthermore, the LC3 gene expression was increased in all HFD groups as well as the p62 gene expression in group treated with turmeric (p=0.020) and fenofibrate (p=0.005).Conclusions: Mangosteen decreases inflammation and fat degeneration scoring, while turmeric  increases autophagy in the kidney of HFD induced Wistar rats.
Influence of Drying Temperatures on Color Variation, Phenolic Compounds and Multi-Elemental Composition of Some Culinary- Medicinal Mushrooms
Authors: Nasarudin Nur-Amirah Izzah , Azilah Abdul-Malek , Yazid Nurulain Syuhada Mohamad , Sukor Rashidah , Raman Jegadeesh , Raseetha Siva
Published: April 2024

Although mushrooms are widely used for nutraceutical purposes, post-harvest storage is extremely crucial to avoid degradation and quality reduction in fresh mushrooms. Drying treatments are commonly applied in the mushroom industry to extend shelf life. Drying may cause instability of food quality and antioxidant parameters due to unsuitable drying temperatures. Therefore, in this research a common set of temperatures typically used by mushroom growers was applied (50°C, 60°C, 70°C) to Ganoderma lucidum, Lignosus rhinocerus, Auricularia auricula-judae, and Schizophyllum commune to analyze color changes and concentration of elements and phenolic compounds. Mushrooms were chosen based on commonly cultivated species among growers. L. rhinocerus dried at 70°C indicated significantly lower L* (78.90) compared to control (89.94). Element retention in each sample differed depending on the species. The amount of calcium was significantly higher in L. rhinocerus (11,893 mg/kg) and A. auricula-judae (10,941.81 mg/kg) when dried at 60°C. Drying at 70°C resulted in significantly higher magnesium for Sch. commune (13,054.38 mg/kg) and A. auricula-judae (80,56.92 mg/kg). Higher levels of iron and manganese were observed in Sch. commune dried at 70°C (216.54 and 10.02 mg/kg, respectively). Gallic acid had significantly higher retention at 50°C for A. auricula-judae and G. lucidum. Meanwhile, L. rhinocerus and Sch. commune showed significantly higher gallic acid at 60°C. It is evident from these results that temperature does affect the food quality and elemental parameters during the drying process for each mushroom.
Clinical diagnostic value of contrast-enhanced ultrasound combined with microflow imaging in benign and malignant renal tumors: A retrospective cohort study
Authors: Kuang Xiufeng , Wang Huiyang , Chai Weilu , Yuan Huafang , He Ting , Shi Mengya , Jiang Tianan
Published: April 2024

This study aims to evaluate the clinical diagnostic value of contrast-enhanced ultrasound combined with microflow imaging (CEUS-MFI) in the differential diagnosis of benign and malignant renal tumors. All patients underwent CEUS, MFI, color doppler flow imaging (CDFI), and CEUS-MFI. The efficacies of these different diagnostic modalities in diagnosing benign and malignant renal tumors were evaluated by Kappa consistency test and the receiver operating characteristic (ROC) curve, with pathological findings serving as the gold standard. CDFI, MFI and CEUS-MFI all demonstrated higher blood flow in malignant tumors compared with benign tumors. Compared with benign tumors, CDFI detected a higher rate of punctate and linear Adler grade 2 and 3 blood flows in malignant tumors, as well as peripheral semicircular or annular blood flow. MFI identified a high rate of peripheral circumferential blood flow and irregular vascular morphology in malignant tumors, with most exhibiting Adler grade 3 blood flow. In addition, CEUS-MFI showed more dendritic or irregular Adler grade 2 or 3 blood flows in malignant renal tumors than MFI alone. Further analysis showed that CEUS-MFI had the highest consistency with pathological diagnosis (Kappa = 0.808). The ROC curve showed that the area under the curve (AUC) for CEUS-MFI in differentiating between benign and malignant lesions was 0.898, significantly outperforming other single diagnostic methods. With its capability to display microvascular information and assess overall pathological characteristics, MFI can accurately predict the nature of renal tumors and assist in surgical planning.
IRANIAN ART OF THE QAJAR ERA: EUROPEAN INFLUENCES AND «PERSIAN STYLE» FOR EXPORT
Authors:   State Museum of Oriental Art, Korotchikova Polina V.
Published: April 2024

The Qajar era (late XVIII-1925) gave the world a unique style, unmistakably recognizable in painting, crafts, and photography. Clumsy, striking the imagination with its amazing brightness of colors and bold artistic techniques, it was formed largely due to active interaction with European culture via respect for the Persian traditional styles. The article deals with the significance of Europe and the European in the formation and development of Qajar art, addressing two opposing processes. Borrowing Western methods and techniques, educational models and new products on the one hand, and European fashion for Persian things, which influenced local production and its transformation on the other. The first process is seen in easel painting and the fashion for "european«details in interior decoration, the second — in «re-creation» of an updated carpet and ceramic production in Persia. The illustrative effect will be provided by selected items from the collection of the State Museum of Oriental Art in Moscow, including court portraits, glass paintings, qalamkaras, tiles, etc.
PETRARCH’S «TRIUMPHS» IN ITALIAN ILLUMINATED BOOK OF QUATTROCENTO: FROM THE TRIUMPHAL THEMES OF ANCIENT ROME TO THE RENAISSANCE SYNTHESIS
Authors:   State Institute for Art Studies, Shidlovskaya Evgenia V.
Published: April 2024

In Renaissance culture, the theme of triumph, dating back to the traditions of ancient Rome, gained special popularity and acquired a new meaning, combined with the idea of Christian virtues. Many painters, miniaturists, masters of engraving, cassone’s and deschi da parto addressed this topic. The famous Petrarch’s «Triumphs» was one of the most beloved and widely illustrated books. The iconography of its miniatures was based on images of chariot processions, which were part of ancient Roman rituals that epitomized victory. The article examines the evolution of illustrations of Petrarch’s triumphs in the art of the illuminated book of the 15th century, the most common iconographic schemes, as well as the connection of these illustrations with painting of the early Renaissance and the heritage of antiquity. Particular attention is paid to the appearance in the miniature of the ХV century a new approach, which united the text and all the elements of page decoration (miniature, border, initials) into one pictorial structure with the design of a page based on the principle of creating a unified pictorial space, but not decorating its individual parts. This space was established on a new visual model of the Quattrocento painting, generating a live synthesis of the ancient heritage, transformed images of the Middle Ages and new Renaissance artistic practice.
THE SECOND DIMENSION. THE CONTEMPORARY ART COLLECTION OF THE CARDIAC SURGEON MIKHAIL ALSHIBAYA
Authors: Lebedeva Yulia S.
Published: April 2024

The article is dedicated to the famous collector of unofficial Soviet and contemporary Russian art, the renown cardiac surgeon, director of the Dept of coronary and vascular surgery of the A.N. Bakulev National Medical Research Centre for Cardiovascular Surgery, Moscow, Mikhail Alshibaya, and to the artworks from his collection. The article provides some details of the collector’s biography, the history of launching and compiling of his collection, its appending, wih some unique cases of acquisition of items, and the collector’s reflections on art, collecting and life. An attempt follows to analyse the collection of the material, included in 2014 into the permanent display of the «Other Art» museum at the premises of the Russian State University for the Humanities in Moscow. The artworks, chosen for display, presented the collection as a one whole unity. This exhibit is an attempt to present the history of Russian art of the last 80 years on the example of the artworks, accumulated by a private person, and in many cases, incidentally. The collector’s comments, recorded for the article, disclose some mysteries of acquisition of the artworks, and the «exhumation», as he likes calling it, of forgotten artists. To save these artists and their work from oblivion is the main topic of activity of Mikhail Alshibaya, who is a collector-researcher at its full.
SOLOMON TELINGATER’S AND ALEXANDER BEZYMENSKY’S KOMSOMOLIA: A PROPAGANDA COMIC STRIP OR A MASTERPIECE OF CONSTRUCTIVIST TYPOGRAPHIC ART?
Authors:   HSE Art and Design School, Sakhno Irina M.
Published: April 2024

The article provides a study of Komsomolia (1928) — a poem by Alexander Bezymensky set for print by Solomon Telingater. This text has been both long out of print and beyond the scope of critical attention both in Russia and beyond it, for almost a century. This book is reassessed here within the context of contemporary scholarship, as a specimen of literature of the 1920s, as a first-hand account of the life of members of the Komsomol (Young Communists Organization) during the years of the Russian Civil war, and last of all, as a masterpiece of Constructivist art which embodied the experimental typography of the Russian avant-­garde art. Transcending ideological bias, this article focuses on the realities of history and the most conspicuous markers of time which had influenced the contexts of the poem and informed its Romanticist drive. Using arguments from Bezymensky’s biography, the author argues that the view of Komsomolia as a Soviet propaganda comic strip, a narrative set in a sequence of simple pictures and photos, is too straightforward and can be extracted from the political expedience of its times. It were the polystylistics and polyphony of Komsomolia which informed its graphic art and formed the core of Telingater’s typographic experiment. Within this experimental space, the artist displays Komsomolia’s intricate architectonics and fascinating construction techniques, which makes use of such novel devices as photomontage, poetics of a cinematic frame, accentuating the text, figurative accidence, typographic drawing, as well as the visual optic of the ‘bioscopic book’.
AVANT-GARDE RECEPTIONS IN SOVIET MASS TEXTILES OF THE 1930S
Authors:   The Museum of Moscow, Guseva Ksenia L.
Published: April 2024

The article describes how the basic principles and approaches of the avant-­garde synthetic thought were applied and reinterpreted in the art of mass production textiles in the 1930s. The situation in textile industries in the first revolutionary years is briefly outlined, as well as the reasons that forced both avant-­gardists and government representatives to pay attention to the issue of systematic education of textile artists. This article examines how the textile faculty of Vkhutemas-­Vkhutein became the place of formation of a new type of artist, who fully manifested himself after graduating from the institute in the 1930s. Being authors who possess equally artistic skills, project thinking, knowledge of technical and chemical factors, and capable to solve problems of various nature, they were able to demonstrate the reliability of the program proposed by the pedagogues of the main avant-­garde school for the textile art industry. Despite the obvious difference between the drawings for fabrics of the avant-­garde period and the subsequent decade, the continuity of the educational approach is common, which demonstrated itself at the moment of the turning point of aesthetic and ideological ideas. Lia Raitzer, Vera Lotonina, Daria Preobrazhenia, Maria Anufrieva, Dina Lekhtman-­Zaslavskaya, Maria Shuikina and other students of the formal method showed how knowledge of propaedeutics and synthetic interdisciplinary thinking helped them to adapt to the new aesthetic, ideological and industrial aspects and at the same time contain their signature handwriting.
A Novel 3D Multi-Layer Convolutional Neural Networks for Lung Cancer Segmentation in CT Images
Authors:   Professor, Department of Computer Science, University of Madras, Chennai, 600025, TamilNadu, India, Chithra P L , Bhavani P
Published: April 2024

Background/Objectives: A novel three-dimensional efficient Multi-Layer Convolutional Neural Network (3D-MLCNN) is proposed for detecting lung tumors accurately using Computerized Tomography (CT) lung tumor images. The proposed K-means segmentation algorithm for labeling the tumor region automatically. This proposed K-means segmentation algorithm automatically labels the tumor regions to process with the 3D MLCNN model to predict tiny tumors and extract tumor regions accurately. Methods: The proposed 3DMLCNN network goal is to extract the tumor region in CT lung images to classify the lung tumor volume by pixel-wise segmentation model. Findings: The proposed 3D MLCNN segmentation model for detecting the segmenting tumors produces outperforming results for predicting even tiny tumors in the lung images. Experimental results demonstrated with lung cancer CT images in TCIA datasets show that the proposed model 3D-MLCNN achieved a dice coefficient (9.6%), Intersection over Union (IoU) (80%), F1-Score (9.33%), Sensitivity (17.11%), and Accuracy (98%) respectively. However, the proposed model 3D MLCNN was evaluated and compared with the existing state-of-the-art segmentation methods, which shows a 10% improvement in the segmentation process. Novelty: A novel 3D MLCNN model enhances the tumor region and predicts the tumor accurately by labeling the tumor using K-means labeling techniques. Keywords: 3D Convolutional Neural Networks, Lung Cancer CT Images, K - Means Labeling, Feature Visualization, Deep Learning