bluuebunny/crossref_metadata_2025 huggingface dataset:
The legal framework of public civil archives in Spain
Authors: Bordas Prószynski Miquel
Published: August 2023

The origins of modern legislation regulating civil public archives in Spain date back to the 19th century, although some of Spain’s current historical archives, such as the Archives of the Crown of Aragon, have their roots in the Middle Ages. In the second half of the 19th century, the need to preserve collections of the Inquisition, as well as from confiscated monasteries and religious houses, gave rise to the establishment of the State Historical Archive. The aforementioned legislation has been extensively revised since 1978 to additionally reflect the new Spanish territorial political model established by the current Basic Standard, which has gradually established a complex system of competencies in the field of public archives in Spain, depending on whether they are owned by the state (State Archives System) or by Spanish autonomous communities or other territorial public administrations (Autonomous Communities Archives System), as it has been outlined in the case law of the Constitutional Court of Spain. From the point of view of the Spanish state, Law 16/1985 of 25 June on the Spanish historical heritage is the basic normative act for the regulation of the state’s public archives, currently under the Ministry of Culture and Sports, specifically, under the General Subdirectorate of State Archives. The said archives are under the authority of a special body of officials – archivists, librarians and archaeologists. On the other hand, at the level of the Autonomous Communities, each Autonomous Community has approved its own specific legislation regarding the archives they own or have jurisdiction over. In this regard, by way of example and in relation to their representativeness, the legislation of the autonomous communities of Andalusia (current Law 7/2011 of 3 November on documents, archives and documentary heritage of Andalusia) and Catalonia (current Law 10/2001 of 13 July on archives and the circulation of records) has been discussed.
Performance of different genotypes of pummelo (Citrus grandis L.) for softwood grafting success and growth parameters
Authors: Koti Shivanand , Swamy G. S. K. , Rao Venkat , J. Jayappa  , Ugalat Jayashree
Published: August 2023

Pummelo (Citrus grandis L.) is one of the important tropical fruit crops among the citrus group. Since pummelo is a monoembryonic and crosspollinated crop, vegetative propagation is critical for obtaining true-to-type plants. A study entitled “Performance of different genotypes of pummelo (Citrus grandis L.) for softwood grafting success and growth parameters” was carried out in the Department of Fruit Science, College of Horticulture Bengaluru in 2022. The experiment was laid out in a completely randomised design (CRD) with ten genotypes in three replications to know the response of softwood grafting success on locally gathered scions of elite Devanahalli pummelo genotypes was assessed. In February, they were grafted onto sixmonth-old rangpur lime rootstock. The results revealed that the genotype DSP-8 had recorded the significant minimum days (13) for bud breaking, the maximum graft success (96.67 %) and survivability (100.00 %). The genotype DSP-12 had a significantly maximum graft height at 30, 60, 90 and 120 days after grafting (DAG) (11.60, 14.73, 17.07 and 19.91 cm, respectively) and graft girth at 30, 60, 90 and 120 DAG (3.16, 3.95, 4.95, and 6.01 mm, respectively). Whereas the DSP-5 genotype had recorded significant maximum sprouts at 60, 90 and 120 DAG (3.67, 4.34 and 4.34, respectively) and the DSP-8 genotype had recorded the maximum number of leaves at 30, 60 and 120 DAG i.e., 7.67, 11.67 and 20.34. Among the different genotypes DSP-8 and DSP-12 recorded higher graft success, and these genotypes can be exploited for commercial production.
Analysis of the Selection and Installation of a Pump for an Overflow Swimming Pool with a Volume of 67 Cubic Meters
Authors:   Politeknik Negeri Bali, Wibolo Achmad , Suherman I Ketut ,   Politeknik Negeri Bali, Pancarana I Dewa Made ,   Politeknik Negeri Bali, Adi I Ketut ,   Politeknik Negeri Bali
Published: August 2023

In the swimming pool there is a pump system that is useful for circulating water. Pumps in swimming pools can affect water quality. Dirty water will be cleaned by the filter and will be re-circulated to the swimming pool. The calculations that must be known are the volume of the swimming pool, pump power, flow rate, and the curve of the pump. In order for the selection of a swimming pool pump to be appropriate, the correct calculation must be made so that the pump can provide the best performance for a swimming pool with a volume of 67 cubic meters and is able to circulate swimming pool water 4 times during 12 working hours.
The Effect of Implementation of Construction Safety Management Sytem on The Level of Work Accidents
Authors:   Politeknik Negeri Jakarta, Defila Sri , S Kusumo Drajad ,   Politeknik Negeri Jakarta, S Kartika Hapsari ,   Politeknik Negeri Jakarta
Published: August 2023

The high number of construction accidents in infrastructure development projects in Indonesia is caused by the risk of danger that exists at every stage of construction. The implementation of the Construction Safety Management System (SMKK) is a manifestation of the labor protection system and for construction work, SMKK can minimize and avoid the risk of fatal work accidents. This study aims to determine the effect of the application of SMKK elements on the level of work accidents and find out the elements that greatly affect the level of work accidents in the X Toll Road Construction Project. Data collection methods are the distribution of questionnaires and interviews. Data analysis was performed using statistical analysis, namely multiple linear regression analysis. From the results of the study, based on the partial hypothesis test, it was obtained that the application of SMKK elements that partially affect the level of work accidents is the 3rd element, namely Construction Safety Support, while the other 4 elements do not have a significant influence on the level of work accidents and based on simultaneous hypothesis tests, it is obtained that the simultaneous application of SMKK elements has a significant influence on the level of work accidents. The results of the multiple regression equation show that the construction safety support element with a negative value means that it has the greatest influence that gives the possibility of work accidents occurring low compared to other SMKK elements.
Behavior And Performance Of Steel Frame Structures With X-Type Concentric Bracing System Due To Variations In Comparison Of Span Width To Story Height (L/H)
Authors:   Universitas Pendidikan Nasional, Kumara I Nyoman Indra , Tapa I Gede Fery Surya ,   Universitas Pendidikan Nasional, Susila I Nengah Darma ,   Politeknik Negeri Bali
Published: August 2023

X-type bracing is the strongest bracing. The bigger ratio of the width of the span to the high level (L/H), the slope of the angle on the bracing will be more declivous. The analysis of the structure with the L/H ratio to determine the behavior of the structure using linear analysis of response spectrum and structural performance using the static nonlinear pushover analysis (ETABS 2016) to determine the displacement target that occurred in the structure. Structural modeling is done on 3D portals with levels of 3, 5, 8 and 10 floors with different L/H variations, including L/H=1; L/H=1.25; L/H=1.5; L/H=1.75; and L/H=2. Structural modeling is planned to be in the Surabaya area with moderate soil conditions. This study obtains data such as: (1) The largest maximum drift and floor drift are at type L/H=2, (2) The largest base shear force in the nonlinear pushover analysis at each story occurs at L/H=1, (3 ) In the yield condition type L/H=1 has the smallest percentage of structural stiffness, but in the ultimate condition type L/H=1 has the largest percentage of structural stiffness, and (4) The highest ductility value at each story occurs in type L/H=2 . Based on these results, it shows that the greater the type of L/H in the bracing structure, the greater the displacement target produced. If the angle of bracing becomes more sloping, then the displacement and target displacement that occurs increases.
The Effect of Non-Excusable Delay Factors on The Completion of Building Construction Projects
Authors:   Politeknik Negeri Jakarta, Dunaufal Alvin , Sucita I Ketut ,   Politeknik Negeri Jakarta, Saputra Jonathan ,   Politeknik Negeri Jakarta
Published: August 2023

A problem that often occurs in construction projects is the delay in the implementation process. Various factors cause the delay, but in developing countries such as Indonesia, the dominant delay occurs because the implementing contractor causes it for unforgivable reasons (non-excusable delay). This study aims to determine the influence of the non-excusable delay parameter and the relationship between these factors. The research is quantitative with data collection techniques in the form of unstructured interviews, field observations, and surveys using research questionnaires with the number of respondents obtained as many as 33 people consisting of the owner, construction management consultant, quantity surveyor consultant, and ends with confirmation of the results. Research on the implementing contractor. Data analysis was performed using multiple linear regression analysis. The test results of multiple linear regression analysis show that the non-excusable delay factor can significantly affect the completion of construction projects. The influence of each element is 0.434 units for the lack of contractor competence, 0.067 units for inappropriate implementation planning, and -0.097 for inefficient field management units. And simultaneously, these three factors can significantly increase the project delay value index.
DESCRIPTION OF PREGNANT WOMEN'S KNOWLEDGE ABOUT ANEMIA
Authors: Windari Fitri , Rosmawati Dwi , Anggaraini Heni , Ningsih Tri Riwayati
Published: August 2023

Background :: Anemia is a health problem that affects people worldwide and affects both developed and developing countries. Anemia occurs during every human life cycle, with one in four suffering from anemia. Most people with anemia are pregnant women. Anemia is an indirect cause of death for pregnant women. According to the World Health Organization (WHO), defines anemia during pregnancy as a hemoglobin level of less than 11 g or less than 33% at any time during pregnancy. The hemoglobin level during pregnancy is less than 11 g and is in early pregnancyObjective: Explain the characteristics of pregnant women's knowledge about anemia based on age, education level, and mother's occupationMethods: Quantitative descriptive research with a study with a total of 56 respondents in the Working Area of the Karang Anyar Health Center, South Lampung. Data collection used a questionnaire sheet, data testing was carried out using Chi Square.Research result: the characteristics of the respondents which include age, education level, and mother's occupation, most of the respondents are aged 20-35 years, with a high school education level, the second article has elementary school education, and the respondent's occupation is that most of the respondents do not work. An overview of pregnant women's knowledge about anemia was obtained from the majority in the sufficient category. Knowledge can be influenced by the support factor from the family. Other factors that can help pregnant women's knowledge about anemia with education and information from health workers must be further improved so that the quality of knowledge of pregnant women will be even betterConclusion: Knowledge of pregnant women about anemia can be influenced by factors from family support and health workers, education of pregnant women and motivation for health education so that the quality of knowledge of pregnant women is getting better.
“This Year Book...has been entirely produced by staff and students”: Indigenous Youth, Indian Schooling, and Historical Production in the Northwest Territories, 1959-71
Authors: Fraser Crystal Gail , Dunkin Jessica
Published: August 2023

In 1960, two of the newly constructed schools in the Northwest Territories (NWT) published yearbooks for the first time. By the end of the decade, yearbooks were a common feature of school life in the territory. While school yearbooks have been important for historians working in a variety of subdisciplines, there is little methodological writing on these sources. In this article, which draws on yearbooks from seven Indian residential and day schools in the NWT, we provide historians with a set of questions and considerations for working with yearbooks generally and those produced within Canada’s system of “Indian education” specifically. We conclude with a discussion about using yearbooks to write histories of “Indian schooling” that includes a brief examination of yearbooks as sources for writing about recreation at residential and day schools.
The Quiet Revolution and the Creation of Concordia University
Authors: Rudin Ronald
Published: August 2023

Concordia University was created in 1974 out of the merger of Jesuit-run Loyola College with Sir George Williams University, but the process leading to this new university stretched back to the mid-1960s, along the way reflecting the secularization of Quebec society that was one of the hallmarks of the province’s Quiet Revolution. Loyola College faced an existential crisis when the Université de Montréal ended a long-standing arrangement by which it granted degrees to Loyola students. This arrangement reflected the power of religion, and especially Catholicism, in Quebec society that was now under attack, with language taking its place. Ultimately, Loyola was only able to continue offering university degrees by merging with Sir George Williams to form Concordia, a development that was deeply embedded in the combustible politics of language in Quebec at the time.
Technology and implementation of fermentative units for bioprotein production from natural gas
Authors: Kochetkov V. M. , Gaganov I. S. , Kochetkov V. V. , Nyunkov P. A.
Published: August 2023

Objectives. To conduct a comparative analysis of the features of a fermentation unit design for obtaining bioprotein from natural gas and determine the main technical and structural solutions used in the development of fermentation apparatus, which vary according to the method of organizing hydraulic and mass transfer processes.

Results. An analysis of publications devoted to the problem of developing technological equipment for conducting the process of obtaining a bioprotein from natural gas is presented. Using the comparative analysis, the key features of bioreactors and their internal elements are indicated according to the method of organizing the hydrodynamic regime. The main approaches to the technological development of fermentation units for obtaining bioprotein from natural gas are described and technical solutions used in the implementation of these structures are identified.

Conclusions. Fermenter designs for the cultivation of methane-oxidizing microorganisms vary according to the main approaches for implementing the hydraulic regime inside the apparatus. While one class of fermentation systems is based on the principle of volumetric mixing in the working space of the apparatus, with the possibility of including external circulation circuits, additional tanks, and auxiliary bioreactors in the system, the other main class relies on the principle of flow (displacement) in the tube space with subsequent release of the gas phase from the circulating culture liquid.
Implementation of pharmaceutical development using multivariate analysis of multi-criteria optimization on the example of the stage of purification of oligohexamethyleneguanidine hydrosuccinate
Authors: Shatalov D. O. , Trachuk K. N. , Aydakova A. V. , Akhmedova D. A. , Ivanov I. S. , Minenkov D. S. , Blazhevich I. Yu. , Kedik S. A.
Published: August 2023

Objectives. The study set out to use mathematical modeling, in particular the method of multifactorial analysis of multicriteria optimization (MAMO), in the development of a pharmaceutical product.

Methods. After carrying out experimental tests based on the proposed algorithmic sequence, the obtained data were interpreted using MAMO.

Results. The possibility of using MAMO to solve the applied problem of purifying oligohexamethyleneguanidine hydrosuccinate (OHMG-HS), considered as a pharmaceutical precursor for the creation of medicines, was demonstrated.

Conclusions. The expediency of using the proposed algorithm as a tool for pharmaceutical development is substantiated by identifying dependencies of the influence of purification conditions on the final content of admixtures in the target product.
Multi-task neural network for solving the problem of recognizing the type of QAM and PSK modulation under parametric a priori uncertainty
Authors: Paramonov A. A. , Nguyen V. M. , Nguyen M. T.
Published: August 2023

Objectives. Automatic modulation recognition of unknown signals is an important task for various fields oftechnology such as radio control, radio monitoring, and identification of interference and sources of radio emission. The paper aims to develop a method for recognizing the types of signal modulation under conditions of parametric a priori uncertainty, including the uncertainty of carrier frequency- and initial signal phase values. An additional task consists in estimating the offset values of the carrier frequency or signal phase at the initial stage of the recognition process.

Methods. A multi-task learning with artificial neural network and the theory of cumulants of random variables are used.

Results. For signals with a carrier frequency and initial phase shift, cumulant approaches for QAM-8, APSK-16, QAM-64, and PSK-8 modulations are calculated. A multi-task learning with artificial neural network using cumulant features and a data standardization algorithm is presented. The results of the experiment show that using multi-task learning with an artificial neural network provides high accuracy of recognizing QAM-8 and APSK-16, QAM-64 and PSK-8 modulations with small mismatches of the carrier frequency or initial phase. The accuracy of determining the offset values from the carrier frequency or the initial phase for QAM-8, APSK-16, QAM-64, and PSK-8 modulation is high.

Conclusions. The multi-task learning with neural network using high-order signal cumulants makes it possible not only to recognize modulation types with high accuracy under conditions of a priori uncertainty of signal parameters, but also to determine the offset values of carrier frequency or initial signal phase from expected values.
Peningkatan Daya Saing UMKM Kuliner di Bumi Sebalo Melalui Metode Score Plus
Authors: Ayustia Rissa , Nadapdap Jones Parlindungan , Salfarini Eligia Monixa
Published: August 2023

Kegiatan pengabdian kepada masyarakat ini bertujuan untuk meningkatkan daya saing melalui peningkatan kinerja pada Usaha Mikro, Kecil, dan Menengah (UMKM) kuliner Dapoer Tela Bumi Sebalo. UMKM kuliner di daerah, khususnya di Bumi Sebalo Bengkayang menghadapi berbagai tantangan, termasuk persaingan bisnis yang ketat dan keterbatasan akses terhadap pasar yang lebih luas. Metode yang diterapkan dalam pengabdian ini adalah SCORE PLUS, sebuah pendekatan holistik yang dirancang untuk meningkatkan kinerja dan daya saing usaha atau organisasi. Pendekatan ini mencakup empat komponen utama (Strategi, Keuangan, Operasional, Rantai Pasok) yang dianalisis dalam konteks yang lebih luas melalui penerapan dua elemen tambahan (Ekosistem dan Lingkungan Usaha). Melalui serangkaian pelatihan, pendampingan, dan konsultasi, UMKM kuliner ini diberikan pengetahuan dan keterampilan baru untuk mengoptimalkan operasional dan strategi bisnisnya. Selain itu, juga diajak untuk memanfaatkan teknologi informasi dan pemasaran digital guna memperluas jangkauan pasar dan menjangkau konsumen potensial secara lebih efektif. Hasil evaluasi menunjukkan bahwa penerapan metode SCORE PLUS berhasil meningkatkan kinerja UMKM kuliner Dapoer Tela yakni sebanyak  25%  yang di antaranya mengalami peningkatan dari sisi jumlah pelanggan  dan  merasa lebih percaya diri dalam mengelola bisnisnya.
Pendampingan Story Telling Pada Anak Terdampak Gempa Cianjur Di Kp. Seuseupan Kec. Cugenang, Cianjur
Authors: Ratnasari Kania , Utami Annisa Retno , Fahririn Fahririn
Published: August 2023

Pada 21 November 2022, Indonesia dilanda gempa bumi tepatnya di daerah Cianjur, Jawa Barat. Salah satu lokasi yang terdampak dari adanya gempa tersebut yaitu Kampung Seuseupan RT 05, RW 01, Desa Wangunjaya, Kecamatan Cugenang. Pada kampung tersebut terdiri dari 130 KK (kartu keluarga) dan 90 orang anak-anak yang terdampak akibat adanya gempa tersebut. Hal tersebut membuat khususnya anak-anak merasa trauma dan takut. Salah satu cara yang dapat dilakukan untuk membantu anak-anak mengembalikan rasa trauma dan takut adalah dengan cara mendongeng (story telling). Story telling yang dilakukan dengan membuat suasana rileks kepada anak-anak, serta melakukan interaksi dan bermain games untuk membuat suasana rileks tersebut. PKM ini bertujuan untuk mengembalikan sedikit demi sedikit rasa trauma dan takut pasca gempa, membantu anak-anak lainnya lebih dekat dan saling kenal untuk menumbuhkan kembali rasa aman dan rasa kebersamaan serta membuat mereka tertawa senang dan sejenak melupakan ketakutan akan bencana yang mereka alami dan terhibur dengan dongeng yang dibawakan. Pengabdian masyarakat ini menfokuskan dengan memberikan materi trauma healing berupa story telling dan games. Kemudian pendistribusian perlengkapan sekolah lengkap, terpal dan makan siang serta pendampingan berupa trauma healing dengan pendekatan story telling dan games kepada anak-anak korban gempa selain itu kegiatan ini juga memberikan pendampingan kepada anak-anak korban gempa untuk dapat mengurangi rasa takut dan trauma yang dialami oleh anak-anak dan mereka kembali semangat melakukan aktivitasnya terutama belajar dan sekolah.
Pendampingan Penyusunan Laporan Keuangan Pada KPM PKH Yang Mempunyai Usaha Di Kota Depok
Authors: Damayanty Prisila , Yulianto Kampono Imam , Utomo Kabul Wahyu , Nurdiana Diah , Febriantika Febriantika , Utama Rivara Pascha , Amalia Tyara
Published: August 2023

Dalam menjalankan usaha tentunya kita diharuskan untuk bisa mengelola keuangan dengan baik agar usaha berjalan dengan lancar, hal ini membutuhkan laporan keuangan agar bisa melihat kinerja keuangan tersebut terkelola dengan baik. Banyak para UMKM dari KPM PKH yang belum menerapkan laporan keuangan dalam usahanya. Oleh karena itu, dilakukan pengabdian masyarakat ini kepada UMKM dari KPM PKH yang berada di Wilayah Kecamatan Tapos Kota Depok dengan materi penerapan akuntansi sederhana. Tujuan dari kegiatan ini yaitu agar para pelaku usaha mendapatkan ilmu dalam melakukan pembukuan sederhana untuk digunakan dalam pengambilan keputusan usaha kedepannya. Metode pelaksanaan dalam kegiatan ini yaitu dengan penyampaian materi dan diskusi. Berdasarkan hasil yang kami dapat setelah melakukan sosialisasi mengenai penerapan akuntansi dasar kepada kelompok UMKM dari KPM PKH yaitu kurangnya pemahaman terhadap penyusunan laporan keuangan, keterbatasan pengetahuan mengenai software akuntansi.
Pengenalan Literasi Pasar Modal Sebagai Sarana Menabung Saham Bagi Siswa Smk Negeri 9 Kota Semarang
Authors: Sidiq Asah Wiari , Permanasari Rusdiana , Romadon Ahmad Sahri
Published: August 2023

Pemahaman investment society sangat diperlukan dengan cara sosialisasi secara berkelanjutan yang melibatkan berbagai pihak agar pemahaman tentang literasi pasar modal kepada masyarakat dapat terus berkembang yaitu dengan mensosialisasikan kepada masyarakat terutama genarasi milenial bahwa investasi di pasar modal itu mudah, terencana, dan murah. Pengenalan literasi pasar modal sebagai sarana menabung saham bagi siswa SMK bertujuan untuk mengedukasi siswa sebagai generasi milenial agar melek terhadap literasi investasi pasar modal sehingga diharapkan siswa dapat tertarik mengikuti edukasi literasi investasi pasar modal selanjutnya tertarik dan berminat untuk menabung saham dengan membuka rekening pasar modal. Metode pelaksanaan kegiatan pengabdian kepada masyarakat berupa pemberian pembelajaran kepada mitra berupa ceramah atau pemberian materi kepada siswa di kelas tentang pengenalan literasi keuangan, pembelajaran pengenalan investasi pasar modal saham dan perlunya menabung sejak dini, selanjutnya diskusi dan tanya jawab mengenai literasi menabung saham serta evaluasi kegiatan. Hasil PKM  menunjukan adanya peningkatan pengetahuan dan pemahaman mengenai literasi investasi pasar modal sebagai sarana menabung saham bagi siswa SMK Negeri 9 Kota Semarang.
NUTRITION EDUCATION MODELS IN PREGNANCY TO INCREASE KNOWLEDGE AND DIETARY PATTERNS: A SYSTEMATIC REVIEW
Authors: Suryani Suryani , Rusdi Muhammad , Johari Asni , Elrifda Solha
Published: August 2023

Background. The misconception of nutritional principles causes dietary oversight, resulting in an excess or deficit of energy and specific nutrients essential for the proper course of pregnancy and a child’s healthy growth. This review aims to evaluate the effectiveness of nutrition education in improving knowledge and dietary change conducted in pregnant women. Methods. This review study complies with the 2009 PRISMA guidelines. The studies included in this review are mainly studies with experimental designs. Databases used in searching relevant literatures such as PubMed, ScienceDirect, Willey online Library, Web of Science, Cochrane, and Proquest that were published from 2010 to 2021, full text, English version, experimental studies. Two review authors conducted studies screening based on the eligibility criteria, and extracted important points in the studies included. Quality of the studies included were assessed using EPHPP. Results. A total of 10 studies were identified in this review. Six studies in the high quality, and four studies in moderate quality. Overall outcomes of the studies included are Knowledge, Attitude, practice, dietary practice, awareness, hemoglobin blood level, and Gestational Weight Gain (GWG). Conclusion. Nutrition education in many methods has a power to improve knowledge, and dietary change of pregnant women. It implies the need for future large high quality trials using a standardized approach to measuring and reporting similar findings across studies.
Penerapan Model Megacita pada pembelajaran PPKn di SD Negeri Keputran 1 Yogyakarta
Authors: Kurniawan Arie
Published: August 2023

Salah satu cara untuk meningkatkan peran aktif siswa dalam pembelajaran adalah dengan menggunakan model pembelajaran Think-Pair-Share. Berkaitan dengan hal tersebut, Balai Pengembangan Media Radio Pendidikan dan Kebudayaan mengembangkan Megacita suatu model pembelajaran PPKn yang mengadopsi Think-Pair-Share dengan tujuan meningkatkan kemampuan komunikasi, kolaborasi, berpikir kritis dan memecahkan masalah, serta kreativitas dan inovasi siswa. Penelitian ini bertujuan untuk mengetahui bagaimanakah penerapan Megacita pada pembelajaran PPKn di SDN Keputran 1 Yogyakarta mulai dari persiapan hingga hambatan yang dihadapi. Pendekatan yang digunakan dalam penelitian ini adalah kuantitatif dengan metode  analisis data berupa deskriptif kuantitatif. Pada penerapan pertama, siswa masih belum paham dengan aktivitas pembelajaran yang harus mereka lakukan. Sebagian besar siswa juga masih pasif dalam proses diskusi, serta belum berani melakukan presentasi di depan kelas. Pada penerapan kedua, siswa lebih aktif dalam mengikuti pembelajaran, mereka semakin aktif dalam diskusi kelompok, dan sudah berani melakukan presentasi di depan kelas. Hambatan yang dihadapi dalam penelitian ini adalah kesiapan siswa dalam mengikuti pembelajaran, karena masih awam dengan Megacita. Dari penelitian ini dapat disimpulkan bahwa penerapan Megacita pada pembelajaran PPKn di SDN Keputran 1 Yogyakarta sudah berjalan sesuai dengan panduan. Tujuan dari pengembangan model Megacita juga sudah tercapai dengan meningkatnya kemampuan komunikasi, kolaborasi, memecahkan masalah dan inovasi siswa.
Relationship between the Gene Expression of Adenosine Kinase Isoforms and the Expression of CD39 and CD73 Ectonucleotidases in Colorectal Cancer
Authors: Zhulai Galina A. , Shibaev Mikhail I.
Published: August 2023

Tumor cells have the capacity to create an adenosine-rich immunosuppressive environment, which can interfere with antitumor immunotherapy. Approaches are currently being developed with a view to suppressing the production of adenosine or its signals. Such approaches include the use of antibodies to inhibit CD39, CD73, and adenosine-receptor antagonists. However, the abundance of enzymatic pathways that control the ATP-adenosine balance, as well as the still poorly understood intracellular adenosine regulation, makes the hoped-for success unlikely. In the present study, the enzyme adenosine kinase (ADK) needed to convert adenosine to adenosine monophosphate, thereby regulating its levels, was investigated. To do so, peripheral blood samples from patients with colorectal cancer (CRC) (n = 31) were collected with blood samples from healthy donors (n = 17) used as controls. ADK gene expression levels and those of its long (ADK-L) and short (ADK-S) isoforms were measured. The relationship between the levels of ADK gene expression and that of CD39, CD73, and A2aR genes was analyzed. It turned out that in the group of CRC patients (stages III-IV), the level of ADK-L mRNA was lower (p 0.0011) when compared to that of the control. For the first time, an average correlation was found between the level of expression of CD39 and ADK-S (r = -0.468 at p = 0.043) and between CD73 and ADK-L (r = 0.518 at p = 0.0232) in CRC patients. Flow cytometry was used to assess the content of CD39/CD73-expressing CD8+, CD4+ and Treg lymphocytes, as well as their relationship with the level of ADK gene expression in CRC patients. But no significant correlations were found.
CRISPR/Cas9 Essential Gene Editing in Drosophila
Authors: Osadchiy Igor S. , Sophia Kamalyan O. , Tumashova Karina Yu. , Georgiev Pavel G. , Maksimenko Oksana G.
Published: August 2023

Since the addition of the CRISPR/Cas9 technology to the genetic engineering toolbox, the problems of low efficiency and off-target effects hamper its widespread use in all fields of life sciences. Furthermore, essential gene knockout usually results in failure and it is often not obvious whether the gene of interest is an essential one. Here, we report on a new strategy to improve the CRISPR/Cas9 genome editing, which is based on the idea that editing efficiency is tightly linked to how essential the gene to be modified is. The more essential the gene, the less the efficiency of the editing and the larger the number of off-targets, due to the survivorship bias. Considering this, we generated deletions of three essential genes in Drosophila: trf2, top2, and mep-1, using fly strains with previous target gene overexpression (pre-rescued genetic background).
Connectivity of the Brain in the Light of Chemogenetic Modulation of Neuronal Activity
Authors: Dygalo Nikolai N.
Published: August 2023

Connectivity is the coordinated activity of the neuronal networks responsible for brain functions; it is detected based on functional magnetic resonance imaging signals that depend on the oxygen level in the blood (blood oxygen level-dependent (BOLD) signals) supplying the brain. The BOLD signal is only indirectly related to the underlying neuronal activity; therefore, it remains an open question whether connectivity and changes in it are only manifestations of normal and pathological states of the brain or they are, to some extent, the causes of these states. The creation of chemogenetic receptors activated by synthetic drugs (designer receptors exclusively activated by designer drugs, DREADDs), which, depending on the receptor type, either facilitate or, on the contrary, inhibit the neuronal response to received physiological stimuli, makes it possible to assess brain connectivity in the light of controlled neuronal activity. Evidence suggests that connectivity is based on neuronal activity and is a manifestation of connections between brain regions that integrate sensory, cognitive, and motor functions. Chemogenetic modulation of the activity of various groups and types of neurons changes the connectivity of the brain and its complex functions. Chemogenetics can be useful in reconfiguring the pathological mechanisms of nervous and mental diseases. The initiated integration, based on the whole-brain connectome from molecular-cellular, neuronal, and synaptic processes to higher nervous activity and behavior, has the potential to significantly increase the fundamental and applied value of this branch of neuroscience.
EGFR Suppression Inhibits the Sphere Formation of MCF7 Cells Overexpressing EGFR
Authors: Novak Diana D. , Troitskaya Olga S. , Nushtaeva Anna A. , Zhilnikova Maria V. , Richter Vladimir A. , Meschaninova Mariya I. , Koval Olga A.
Published: August 2023

The epidermal growth factor receptor (EGFR) is an oncogenic tyrosine kinase that is involved in tumor initiation and progression, making EGFR inhibitors and monoclonal antibodies to this receptor essential for anti-tumor therapy. We have previously shown that EGFR transgene expression in the human breast adenocarcinoma cell line MCF7 (MCF7-EGFR) stimulates the 3D spheroid-like growth. The primary focus of our present work was to investigate whether EGFR inhibition could affect the assembly of spheroids or lead to the destruction of pre-existing spheroids. We compared the effects of anti-EGFR siRNA, the anti-EGFR monoclonal antibody cetuximab, and the tyrosine kinase inhibitor AG1478 on dissociated and spheroid MCF7-EGFR cells. MCF7-EGFR cells were found to have a 2.5-fold higher sensitivity towards the cytotoxic effects of cetuximab and AG1478 compared with the parental MCF7 cell line. The suppression of EGFR mRNA with siRNA was found to reduce the sphere formation, whereas treating the pre-existing spheroids had no such effect. Treatment of dissociated spheroids with cetuximab and AG1478 was also found to inhibit the MCF7-EGFR sphere formation. We suggest that EGFR expression is important, at least, during the spheroid formation stage. The transition of a MCF7wt adherent cell culture to MCF7-EGFR spheroids was accompanied by a considerable increase in N-cadherin adhesion proteins. The level of N-cadherin decreased when MCF7-EGFR cells were treated with siRNA and cetuximab. Thus, we have demonstrated that N-cadherin is involved in the EGFR-dependent formation of MCF7-EGFR spheroids. Accordingly, MCF7-EGFR spheroids can be considered a suitable model for studying aggressive hormone-positive breast tumors.
Trilogi Epistemologi Muhammed Abid al-Jabiri
Authors: Anam Ahsanul
Published: August 2023

Mengikuti arus dan tidak terkena arus, layak menjadi kata bijak bagi seorang Jabiri, dengan langkah modernitas yang ia bangun mencoba mengenalkan bangunan epistemologinya pada dunia barat, ia merupakan tokoh yang banyak mencatut wacana lama dan memolesnya dengan gaya baru sehingga orisinalitasnya bisa berkesan seperti yang ia bangun sampai sekarang masih menggema sebagai sebuah wacana. Hal itu menjadi pilihan yang tidak terelakkan, karena mampu mencakup segala hal yang berhubungan dengan sumber pengetahuan. Tujuan dari penelitian ini adalah untuk mendapatkan data-data deskriptif tentang konsep trilogi epistemologi Mohammed Abid Al Jabiri. Penelitian ini menggunakan pendekatan kualitatif dengan mengumpulkan data dari berbagai sumber pustaka seperti buku, majalah, catatan, dan kisah-kisah sejarah. Penelitian ini bersifat menyeluruh (holistik) dengan menganggap keseluruhan sebagai kesatuan yang lebih penting daripada satu bagian. Al-Jabiri mencoba mendasari keilmuan dengan tiga hal, bayani, irfani dan burhani, yang menjadi epistemologi Islam. Namun di sisi lain, pemikirannya banyak menuai kritikan tajam, karena ada unsur subjektifitas yang ia lakukan, jika ada tokoh yang mendukungnya dari pemikirannya, maka ia catut dan mengalahkan pemikir pemikir atau pendapat yang lain, selain itu, pemikir selanjutnya menemukan bahwa pemikiran yang dicetuskan oleh Jabiri adalah sesuatu yang tidak orisinil, hal ini didapat dari pemikir Zaki Najib Mahmud yang dicetuskan pada tahun 1977. Namun setidaknya Jabiri mampu membangun wacana epistemologi dengan trilogi pemikirannya, walau terdapat kesalahan di sana-sini, hal itu merupakan hal yang wajar, karena bagaimanapun juga Jabiri adalah manusia biasa yang mencoba membangun modernitas di dunia Islam tanpa kehilangan ruh Islamnya.
Pentingnya Pendidikan Hukum Islam di Era Digital
Authors: Purborini Vivi Sylvia
Published: August 2023

Pendidikan adalah bagian dari proses belajar untuk membentuk karakter individu pada bangsa dan negara. Kualitas proses pendidikan menentukan hasil dari proses belajar, yaitu arah pemikiran dan langkah kehidupan manusia. Harapan masyarakat cukuplah besar untuk menjadikan seorang anak atau individu bisa mendapatkan pendidikan karakter yang baik, agar menjadi manusia yang berkarakter, berbudi pekerti luhur, dan dapat menjalankan kehidupannya sesuai dengan syariat Islam. Penulis menggunakan metode penelitian hukum normatif untuk meneliti dan menulis pembahasan. Tipe penelitian yang digunakan adalah deskriptif. Penelitian hukum deskriptif bersifat pemaparan dan bertujuan untuk memperoleh gambaran atau deskripsi lengkap tentang keadaan hukum yang berlaku ditempat tertentu dan pada saat tertentu yang terjadi dalam masyarakat. Penelitian ini diharapkan dapat memberikan informasi secara jelas dan rinci dalam memaparkan revitalisasi pendidikan hukum di era digital. Kemajuan teknologi, akses ilmu pengetahuan tanpa batas, membuat manusia dapat menjelajah ruang dan waktu dimanapun dan kapanpun. Hampir semua lini dalam kehidupan sosial bangsa negara dapat difasilitasi dengan teknologi. Hal inilah yang membust revitalisasi pendidikan hukum di era digital menjadi sangat penting untuk membuat lingkungan masyarakat berbangsa dan bernegara tetap kondusif dan selalu menjunjung tinggi nilai-nilai kearifan yang ada serta dengan batasan peraturan yang jelas mengatur segala tingkah laku masyarakat, demi terciptanya peradaban insan manusia Indonesia yang maju berkarakter dengan menjunjung tinggi kearifan lokal. Kemajuan generasi bangsa adalah melalui prose pembelajaran yang baik dan dilakukan secara komprehensif melibatkan berbagai pihak. Oleh karenanya revitalisasi pendidikan hukum di era digital akan terus dibutuhkan untuk terus dikembangkan sesuai dengan kemajuan jaman demi majunya peradaban generasi bangsa.
Mitra Implementasi Kurikulum Merdeka pada Madrasah dan Problematikanya
Authors: Swandari Nurul , Jemani Abdurahman
Published: August 2023

Penelitian ini membahas konsep dan penerapan Kurikulum Merdeka sebagai upaya pemulihan pembelajaran pasca pandemi di Indonesia. Kurikulum Merdeka dirancang sebagai kurikulum yang fleksibel, berfokus pada materi esensial, pengembangan karakter, dan kompetensi peserta didik. Penyusunan kurikulum dimulai dengan penjaringan minat dan bakat siswa sejak dini, sehingga siswa dapat menentukan arah pengembangan bakat dan kemampuannya dengan leluasa. Penelitian ini menggunakan metode penelitian kualitatif dengan pendekatan kepustakaan, yaitu menggali dan memperoleh informasi dari buku, artikel, dan sumber bacaan lainnya. Konsep pendidikan dalam kurikulum merdeka sangat memperhitungkan kemampuan dan keunikan kognitif individu peserta didik di masing-masing madrasah. Namun, penerapan kurikulum merdeka di lapangan mengalami beberapa kendala, antara lain dari peserta didik, pendidik, saran dan prasarana, pimpinan dan kolaborasi di dalam internal lembaga pendidikan itu sendiri. Oleh karena itu, diperlukan loyalitas, persamaan mindset dan kerja sama yang solid di dalam internal lembaga tersebut untuk memastikan pelaksanaan kurikulum merdeka pada masing-masing madrasah dapat terlaksana dengan baik. Meskipun Keputusan Menteri Pendidikan Kebudayaan Riset Dan Teknologi Republik Indonesia Nomor 56/M/2022 tentang Pedoman Penerapan Kurikulum dalam Rangka Pemulihan Pembelajaran telah dikeluarkan, penerapan kurikulum pada masa kondisi khusus masih belum dapat mengatasi ketinggalan pembelajaran. Oleh karena itu, Kurikulum Merdeka diharapkan dapat menjadi solusi yang efektif untuk memulihkan pembelajaran di Indonesia pasca pandemi.
Peran Pendidikan Islam Ditengah Masyarakat Multikultural
Authors: Zainuddin  , Ersi
Published: August 2023

Penelitian ini bertujuan untuk memahami peran pendidikan Islam dalam menghadapi masyarakat multikultural. Masyarakat multikultural merupakan kelompok yang dapat saling menerima dan menghormati perbedaan suku, agama, budaya, jenis kelamin, bahasa, adat istiadat, dan kedaerahan. Multikulturalisme memungkinkan berbagai perbedaan hidup berdampingan dengan penuh rasa saling menghargai. Pesan-pesan keagamaan dalam moderasi beragama mencakup menjaga keselamatan jiwa, menghargai peradaban yang luhur, memperkuat nilai-nilai moderat, menciptakan perdamaian, dan menjunjung pluralisme dengan menghormati kebebasan berpikir, berekspresi, dan beragama. Output dari pendidikan Islam adalah kesalehan individu dan sosial dengan menekankan keadilan, perdamaian, kesetaraan, dan kemanusiaan sesuai dengan konsep "rahmatan lil alamin". Pendidikan Islam secara tegas menghargai keragaman dan multikulturalisme, sesuai dengan ajaran Al-Qur'an dan Hadits yang memiliki tujuan yang sama.
Implementasi Pendidikan Ahklak Sejak Usia Dini Secara Intensif dalam Menghadapi Era Digital
Authors: Aziz Abdul
Published: August 2023

Penelitian ini bertujuan mengungkap implementasi pendidikan akhlak sejak usia dini dalam menghadapi era digital. Metode kualitatif digunakan dengan studi literatur dan analisis dokumen. Hasil analisis menunjukkan bahwa pendidikan akhlak sejak dini harus menjadi bagian integral dari kurikulum untuk membentuk generasi muda yang memiliki moralitas kuat dan bertanggung jawab dalam menggunakan teknologi. Metode pengembangan akhlak anak usia dini melibatkan media permainan, pengembangan panca indera, suasana pembelajaran menyenangkan, serta pemahaman dan penghayatan nilai-nilai akhlak. Strategi pembelajaran mencakup pemupukan nilai, keteladanan, pengembangan keterampilan akademik dan sosial, serta fasilitasi. Implementasi pendidikan akhlak dimulai dengan perencanaan nilai-nilai akhlak yang sesuai dengan tema pembelajaran, indikator, pembiasaan terprogram, dan penilaian yang mencakup tujuan, prinsip, cara penilaian, lingkup, dan instrumen.
Carcinomas Gástricos com Hemorragia ou Perfuração: Uma Retrospecção com 44 casos
Authors: Kobata Clóvis Massayuki , Sato Nelson Yukitoshi , Monteiro Mário da Silva , Chacon Jesus Pan
Published: August 2023

Da análise retrospectiva de 44 doentes com carcinoma gástrico complicado com hemorragia e/ou perfuração, resultou a mortalidade global de 25,0% (11/44). Em sangramentos, a mortalidade em cirurgias realizadas em caráter de urgência foi de 27,3% e, em perfurações, de 44,4% O índice de ressecabilidade foi de 68,3% (gastrectomia total sete doentes; gastrectomia subtotal 21 doentes). A sobrevida, mesmo em doentes ressecados, tem-se mostrado semelhante à observada entre aqueles operados sem estas complicações.
Tumores Malignos do Intestino Delgado
Authors: Ziliotto Júnior Antonio , Mendes José Antonio Mansur , Kunzle Johann Eugen , Delphini Júnior Ovídio
Published: August 2023

Os tumores malignos primários do intestino delgado são raros e freqüentemente diagnosticados em estádios avançados. Num período de 27 anos (1960-1987) foram atendidos no Serviço de Cirurgia de Ribeirão Preto, 17 pacientes com neoplasia maligna de delgado. A maior parte das lesões se assestavam no ileo, com freqüência decrescente a montante. Havia tumores sincrônicos em 35,29% dos casos. Os sinais e sintomas clínicos mais freqüentes foram: dor abdominal (94,12%), náuseas e vômitos (52,94%), perda de peso (52,94%) e anorexia (35,29%). Por ocasião do primeiro atendimento, 3 pacientes tinham peritonite por perfuração do tumor, uma delas subseqüente à radioterapia. Dos exames complementares, o de maior valor foi o estudo radiológico contrastado do delgado. O tratamento consistiu na ressecção do segmento comprometido e do mesentério, incluindo outros órgãos eventualmente envolvidos. Em um caso, apenas a biópsia pôde ser realizada. O tipo histológico mais freqüente foi o linfoma, seguido pelo leiomiossarcoma eadenocarcinoma. Tivemos a lamentar 4 óbitos operatórios (23,53%), 3 por choque séptico (2 operados na vigência de peritonite e 1 por deiscência de anastomose) e 1 por acidente anestésico. Foi empregada a quimio e/ou radioterapia adjuvante em todos os pacientes que sobreviveram o pós-operatóno, à exceção de um paciente que se negou a recebê-los. Todos os 3 pacientes com leiomiossarcoma apresentaram recidiva e foram reoperados. Quatro pacientes estavam vivos por ocasião do último seguimento, com sobrevida entre 2 e 15 anos. A sobrevida de 5 anos foi de 25% para os linfomas (38% quando excluídos os óbitos operatórios) e de 100% para os adenocarcinomas, embora se trate de apenas 2 casos. Desde que os sinais e sintomas nos tumores de delgado são vagos e mal definidos, é necessário que esse diagnóstico seja cogitado para que o diagnóstico mais precoce seja estabelecido e conseqüentemente se tenha um melhor prognóstico.
Estabelecimento de um Método "In Vitro" de Controle Biológico de Agentes Antineoplásicos em Uso no Instituto Nacional de Câncer
Authors: Silva Vera Maria Marques , Arcuri Roberto Alfonso , Rumjanek Vivian M
Published: August 2023

O objetivo do presente trabalho foi desenvolver um método capaz de verificara eficácia, a nível biológico, das drogas antineoplásicas, que não necessitem de metabolismo prévio para sua ação e que atualmente estão sendo usadas no Instituto Nacional de Câncer (INCa). O princípio do ensaio foi baseado na medida de inibição da proliferação celular da linhagem K562 e de células ativadas por fitohemaglutinina (PHA), usando-se como marcadora incorporação no DNA de timidina tritiada. Conclui-se que esse ensaio não é adequado para testara atividade antitumoral do Methotrexate, mas pode ser extremamente sensível para os estudos com derivados da Vinca.