bluuebunny/crossref_metadata_2025 huggingface dataset:
Privacy-Friendly Task Offloading for Smart Grid in 6G Satellite–Terrestrial Edge Computing Networks
Authors: Zou Jing , Yuan Zhaoxiang , Xin Peizhe , Xiao Zhihong , Sun Jiyan , Zhuang Shangyuan , Guo Zhaorui , Fu Jiadong , Liu Yinlong
Published: August 2023

Through offloading computing tasks to visible satellites for execution, the satellite edge computing architecture effectively issues the high-delay problem in remote grids (e.g., mountain and desert) when tasks are offloaded to the urban terrestrial cloud (TC). However, existing works are usually limited to offloading tasks in pure satellite networks and make offloading decisions based on the predefined models. Additionally, runtime consumption for offloading decisions is rather high. Furthermore, privacy information may be maliciously sniffed since computing tasks are transmitted via vulnerable satellite networks. In this paper, we study the task-offloading problem in satellite–terrestrial edge computing networks, where tasks can be executed by satellite or urban TC. A privacy leakage scenario is described, and we consider preserving privacy by sending extra random dummy tasks to confuse adversaries. Then, the offloading cost with privacy protection consideration is modeled, and the offloading decision that minimizes the offloading cost is formulated as a mixed-integer programming (MIP) problem. To speed up solving the MIP problem, we propose a deep reinforcement learning-based task-offloading (DRTO) algorithm. In this case, offloading location and bandwidth allocation only depend on the current channel states. Simulation results show that the offloading overhead is reduced by 17.5% and 23.6% compared with pure TC computing and pure SatEC computing, while the runtime consumption of DRTO is reduced by at least 42.6%. The dummy tasks are exhibited to effectively mitigate privacy leakage during offloading.
Effects of Shading on the Growth and Photosynthetic Fluorescence Characteristics of Castanopsis hystrix Seedlings of Top Community-Building Species in Southern Subtropical China
Authors: Xue Guangyu , Wu Junduo , Zhou Bingjiang , Zhu Xueping , Zeng Ji , Ma Yue , Wang Yanan , Jia Hongyan
Published: August 2023

Castanopsis hystrix is a major community-building species in the top communities of southern subtropical China, with a high natural regeneration capacity. However, excessive logging and the introduction of exotic tree species have substantially reduced the area of natural forest patches of Castanopsis hystrix, and seedling regeneration is essential for the long-term continuation of Castanopsis hystrix populations. To explore the effects of light intensity on the seedling emergence and early growth of Castanopsis hystrix, shading experiments were conducted under four shading treatments (0%, 40%, 60%, and 80%). The growth, biomass accumulation, and distribution, the quality index of seedlings, the morphology and structure of the root systems of seedlings, and the leaf chlorophyll content and chlorophyll fluorescence properties of seedlings under different shading treatments were analyzed. The results displayed the following: (1) Shade intensity impacts growth of Castanopsis hystrix seedlings and biomass allocation, with optimal results observed at 60% shade, leading to the promotion of organic matter production in leaves and the limitation of stem growth. (2) Using a multi-indicator composite index, it was determined that seedling quality for Castanopsis hystrix peaks at 60% shade intensity. (3) Shade significantly impacts the morphology and structure of Castanopsis hystrix’s root system, with most root characteristics peaking at 60% shade, indicating a substantial increase in root development compared to no-shade conditions. (4) The D-values indicated the most suitable shade intensity for seedling growth to be 60%, suggesting that Castanopsis hystrix seedlings are sensitive to light and excessive light can be detrimental to their growth. (5) The 60% shade treatment showed the maximum values of chlorophyll fluorescence characteristics and photochemical activity, with variations in energy conversion efficiency and dissipation reflected in parameters like photochemical burst coefficient (qP), photochemical burst coefficient (qN), the actual photometric yield of PSII under light acclimation (YII), and the maximum photosynthetic electron transport rate in photoinhibition (ETR), thereby supporting seedling growth and maintaining the normal function of photosynthetic organs. In conclusion, 60% shade treatment can effectively improve the growth and photosynthetic characteristics of Castanopsis hystrix seedlings and promote the accumulation of nutrient elements, ultimately promoting their growth.
Characterisation of Chrysoporthe cubensis and Chrysoporthe deuterocubensis, the Stem Canker Diseases of Eucalyptus spp. in a Forest Plantation in Malaysia
Authors: Awing Norida Hanim , Ambrose Annya , Abdu Arifin , Hassan Affendy , Terhem Razak
Published: August 2023

Commercial plantations of Eucalyptus species have been established in Malaysia, especially during the past 10 years, with the aim of sustaining the supply of wood and timber products for industrial use in Malaysia. As part of an assessment of fungal diseases affecting Eucalyptus species in four regions in Malaysia, including Kelantan, Pahang, Sabah, and Selangor, stem canker disease was discovered to be a widespread disease infecting Eucalyptus species in Malaysia. This study aimed to identify the fungus-causing stem canker disease, test its pathogenicity in Eucalyptus, and determine the mating type of isolates from the infected trees. The fungi were identified based on morphology and through comparisons of DNA sequence data from the ITS, β-tubulin 2 gene, and TEF-1α gene regions. Phylogenetic analyses showed that the causal agent of the stem canker was Chrysoporthe cubensis infecting Eucalyptus plantations in Pahang and Chrysoporthe deuterocubensis infecting Eucalyptus plantations in Kelantan, Sabah, and Selangor. We believe this is the first report of Chrysoporthe cubensis-infected Eucalyptus in Malaysia and Southeast Asia, while Chrysoporthe deuterocubensis is the first-reported species infecting Eucalyptus pellita in Malaysia. Moreover, the fact that the mating-type MAT1-1 and MAT1-2 genes and the pheromone genes ppg1, ppg2, pre1, and pre2 were identified in all isolates indicates that Chrysoporthe cubensis and Chrysoporthe deuterocubensis are homothallic mating systems. Pathogenicity was tested on a 3-year-old standing tree, 1-year-old seedling, and detached healthy leaves, which were re-isolated for fulfilling Koch’s postulates. In pathogenicity trials, both Chrysoporthe cubensis and Chrysoporthe deuterocubensis gave rise to lesions on wounded Eucalyptus. Both Chrysoporthe spp. were equally pathogenic to Eucalyptus urograndis and Eucalyptus pellita and should be regarded as a biosecurity concern in Malaysia’s forest plantation industry.
Spectral Analysis, Biocompounds, and Physiological Assessment of Cork Oak Leaves: Unveiling the Interaction with Phytophthora cinnamomi and Beyond
Authors: Guerra Rui , Pires Rosa , Brázio António , Cavaco Ana Margarida , Schütz Gabriela , Coelho Ana Cristina
Published: August 2023

The cork oak tree (Quercus suber L.) symbolizes the Montado landscape in Portugal and is a central element in the country’s social and economic history. In recent decades, the loss of thousands of cork oaks has been reported, revealing the ongoing decline of these agroforestry ecosystems. This emblematic tree of the Mediterranean Basin is host to the soil-born root pathogen Phytophthora cinnamomi, an active cork oak decline driver. In this framework, the early diagnosis of trees infected by the oomycete by non-invasive methods should contribute to the sustainable management of cork oak ecosystems, which motivated this work. Gas exchange and visible/near-infrared (400–1100 nm) reflectance spectroscopy measurements were conducted on leaves of both control and P. cinnamomi inoculated plants. These measurements were taken at 63, 78, 91, 126, and 248 days after inoculation. Additionally, at the end of the experiment, biochemical assays of pigments, sugars, and starch were performed. The spectroscopic measurements proved effective in distinguishing between control and inoculated plants, while the standard gas exchange and biochemistry data did not exhibit clear differences between the groups. The spectral data were examined both daily and globally, utilizing the PARAFAC method applied to a three-way array of samples × wavelengths × days. The separation of the two plant groups was attributed to variations in water content (4v (O−H)); shifts in the spectra red edge; and structural modifications in the epidermal layer and leaves’ mesophyll. These spectral signatures can assist in the field identification of cork oaks that are interacting with P. cinnamomi.
Advancing Epidemiology and Genetic Approaches for the Treatment of Spinal and Bulbar Muscular Atrophy: Focus on Prevalence in the Indigenous Population of Western Canada
Authors: Wilton-Clark Harry , Al-aghbari Ammar , Yang Jessica , Yokota Toshifumi
Published: August 2023

Spinal and bulbar muscular atrophy (SBMA), also known as Kennedy’s disease, is a debilitating neuromuscular disease characterized by progressive muscular weakness and neuronal degeneration, affecting 1–2 individuals per 100,000 globally. While SBMA is relatively rare, recent studies have shown a significantly higher prevalence of the disease among the indigenous population of Western Canada compared to the general population. The disease is caused by a pathogenic expansion of polyglutamine residues in the androgen receptor protein, which acts as a key transcriptional regulator for numerous genes. SBMA has no cure, and current treatments are primarily supportive and focused on symptom management. Recently, a form of precision medicine known as antisense therapy has gained traction as a promising therapeutic option for numerous neuromuscular diseases. Antisense therapy uses small synthetic oligonucleotides to confer therapeutic benefit by acting on pathogenic mRNA molecules, serving to either degrade pathogenic mRNA transcripts or helping to modulate splicing. Recent studies have explored the suitability of antisense therapy for the treatment of SBMA, primarily focused on gene therapy and antisense-mediated mRNA knockdown approaches. Advancements in understanding the pathogenesis of SBMA and the development of targeted therapies offer hope for improved quality of life for individuals affected by this debilitating condition. Continued research is essential to optimize these genetic approaches, ensuring their safety and efficacy.
Steadfast Toll Like Receptor 4 (TLR4) 5-Hydroxymethylcytosine Levels in Cell-Free DNA: A Promising Consistency Marker for Colorectal Cancer Patients
Authors: Jevšinek Skok Daša , Hauptman Nina
Published: August 2023

Cell-free DNA (cfDNA) from patient blood is emerging as a noninvasive diagnostic avenue for various cancers. We aimed to identify reliable biomarkers in cfDNA by investigating genes exhibiting significant differences between colorectal cancer and control samples. Our objective was to identify genes that showed a positive difference between cancer and control samples. To achieve this, we conducted an in silico analysis to identify genes that exhibit no significant variation in methylation between genomic DNA (gDNA) and cfDNA. We collected experimental data from publicly available repositories, which included 5-hydroxymethylcytosine (5hmC) profiles of gDNA and cfDNA samples from both cancer patients and healthy individuals. By comparing and overlapping these two groups, we identified 187 genes of interest, of which 53 genes had a positive difference among colon cancer patients and healthy individuals. Next, we performed an ANOVA test on these genes, resulting in the identification of 12 genes that showed statistically significant higher levels of 5hmC in cfDNA and gDNA from cancer patients compared to healthy individuals. Additionally, we compared the 5hmC status of these genes between cfDNA and gDNA from cancer patients. Interestingly, we found that the 5hmC of the toll like receptor 4 (TLR4) gene was not statistically different between cfDNA and gDNA from cancer patients, indicating consistency between cfDNA and gDNA. These findings have important implications, not only for experimental validation but also for the development of more sensitive and robust noninvasive methods to improve diagnostic, prognostic, and treatment options for colon cancer.
Mechanical Removal of Minnows (Gila bicolor) to Improve Water Quality in a Hydropower Impoundment, Lemolo Lake, Oregon, USA
Authors: Eilers Joseph , Vache Kellie , Grost Richard
Published: August 2023

A project to mechanically remove an over-abundant population of cyprinids (Gila bicolor) was tested in a hydropower impoundment, Lemolo Lake (USA). The netting program removed 29.7 tons of fish (163 kg/ha) over a seven-year period that resulted in a reduction in the intensity and duration of cyanobacteria blooms. However, the suppression of the tui chub population apparently allowed for a residual population of kokanee (Oncorhynchus nerka) to proliferate. The resurgence of the kokanee, combined with the initiation of a rainbow trout stocking program, offset some of the gains in water quality achieved with the reduction of tui chub biomass. The dominant cyanobacterium present in Lemolo Lake transitioned to Gloeotrichia echinulata in 2013, but the majority of these colonies were apparently derived from an upstream lake. The changes in water quality from 2005–2013 were simulated for Lemolo Lake using the two-dimensional, hydrodynamic model, CE-QUAL-W2. The model reproduced many aspects of the water quality in Lemolo Lake and was used, in combination with a simple Bayesian model, to evaluate a number of potential scenarios for further improving water quality in the impoundment. Promoting a deeper drawdown of the hydroelectric impoundment during the winter to selectively increase entrainment of tui chub and kokanee, combined with continued netting targeted at tui chub, was judged to offer the greatest opportunity to manage the facility for water quality, fisheries and hydropower objectives.
Stormwater Infrastructure Resilience Assessment against Seismic Hazard Using Bayesian Belief Network
Authors: Garshasbi Maryam , Kabir Golam , Dutta Subhrajit
Published: August 2023

Resilient stormwater infrastructure is one of the fundamental components of resilient and sustainable cities. For this, the resilience assessment of stormwater infrastructure against earthquake hazards is crucial for municipal authorities. The objective of this study is to develop a resilience assessment framework for stormwater pipe infrastructure against seismic hazards. A Bayesian belief network (BBN)-based stormwater infrastructure resilience model is constructed based on the published literature and expert knowledge. The developed framework is implemented in the city of Regina, Canada, to assess the city’s stormwater pipe infrastructure resilience. The outcome of the model indicates that proposed BBN-based stormwater infrastructure resilience model can effectively quantify uncertainties and handle the nonlinear relationships between several reliability and recovery factors. The model is also capable of identifying the most sensitive and vulnerable stormwater pipes within the network.
Land Use and Land Cover Classification in the Northern Region of Mozambique Based on Landsat Time Series and Machine Learning
Authors: Macarringue Lucrêncio Silvestre , Bolfe Édson Luis , Duverger Soltan Galano , Sano Edson Eyji , Caldas Marcellus Marques , Ferreira Marcos César , Zullo Junior Jurandir , Matias Lindon Fonseca
Published: August 2023

Accurate land use and land cover (LULC) mapping is essential for scientific and decision-making purposes. The objective of this paper was to map LULC classes in the northern region of Mozambique between 2011 and 2020 based on Landsat time series processed by the Random Forest classifier in the Google Earth Engine platform. The feature selection method was used to reduce redundant data. The final maps comprised five LULC classes (non-vegetated areas, built-up areas, croplands, open evergreen and deciduous forests, and dense vegetation) with an overall accuracy ranging from 80.5% to 88.7%. LULC change detection between 2011 and 2020 revealed that non-vegetated areas had increased by 0.7%, built-up by 2.0%, and dense vegetation by 1.3%. On the other hand, open evergreen and deciduous forests had decreased by 4.1% and croplands by 0.01%. The approach used in this paper improves the current systematic mapping approach in Mozambique by minimizing the methodological gaps and reducing the temporal amplitude, thus supporting regional territorial development policies.
Targeting Melanoma-Associated Fibroblasts (MAFs) with Activated γδ (Vδ2) T Cells: An In Vitro Cytotoxicity Model
Authors: Hajdara Anna , Çakır Uğur , Érsek Barbara , Silló Pálma , Széky Balázs , Barna Gábor , Faqi Shaaban , Gyöngy Miklós , Kárpáti Sarolta , Németh Krisztián , Mayer Balázs
Published: August 2023

The tumor microenvironment (TME) has gained considerable scientific attention by playing a role in immunosuppression and tumorigenesis. Besides tumor cells, TME is composed of various other cell types, including cancer-associated fibroblasts (CAFs or MAFs when referring to melanoma-derived CAFs) and tumor-infiltrating lymphocytes (TILs), a subpopulation of which is labeled as γδ T cells. Since the current anti-cancer therapies using γδ T cells in various cancers have exhibited mixed treatment responses, to better understand the γδ T cell biology in melanoma, our research group aimed to investigate whether activated γδ T cells are capable of killing MAFs. To answer this question, we set up an in vitro platform using freshly isolated Vδ2-type γδ T cells and cultured MAFs that were biobanked from our melanoma patients. This study proved that the addition of zoledronic acid (1–2.5 µM) to the γδ T cells was necessary to drive MAFs into apoptosis. The MAF cytotoxicity of γδ T cells was further enhanced by using the stimulatory clone 20.1 of anti-BTN3A1 antibody but was reduced when anti-TCR γδ or anti-BTN2A1 antibodies were used. Since the administration of zoledronic acid is safe and tolerable in humans, our results provide further data for future clinical studies on the treatment of melanoma.
Ezrin Inhibition Overcomes Acquired Resistance to Vemurafenib in BRAFV600E-Mutated Colon Cancer and Melanoma Cells In Vitro
Authors: Car Iris , Dittmann Antje , Vasieva Olga , Bočkor Luka , Grbčić Petra , Piteša Nikolina , Klobučar Marko , Kraljević Pavelić Sandra , Sedić Mirela
Published: August 2023

Despite the advancements in targeted therapy for BRAFV600E-mutated metastatic colorectal cancer (mCRC), the development of resistance to BRAFV600E inhibition limits the response rate and durability of the treatment. Better understanding of the resistance mechanisms to BRAF inhibitors will facilitate the design of novel pharmacological strategies for BRAF-mutated mCRC. The aim of this study was to identify novel protein candidates involved in acquired resistance to BRAFV600E inhibitor vemurafenib in BRAFV600E-mutated colon cancer cells using an integrated proteomics approach. Bioinformatic analysis of obtained proteomics data indicated actin-cytoskeleton linker protein ezrin as a highly ranked protein significantly associated with vemurafenib resistance whose overexpression in the resistant cells was additionally confirmed at the gene and protein level. Ezrin inhibition by NSC305787 increased anti-proliferative and pro-apoptotic effects of vemurafenib in the resistant cells in an additive manner, which was accompanied by downregulation of CD44 expression and inhibition of AKT/c-Myc activities. We also detected an increased ezrin expression in vemurafenib-resistant melanoma cells harbouring the BRAFV600E mutation. Importantly, ezrin inhibition potentiated anti-proliferative and pro-apoptotic effects of vemurafenib in the resistant melanoma cells in a synergistic manner. Altogether, our study suggests a role of ezrin in acquired resistance to vemurafenib in colon cancer and melanoma cells carrying the BRAFV600E mutation and supports further pre-clinical and clinical studies to explore the benefits of combined BRAF inhibitors and actin-targeting drugs as a potential therapeutic approach for BRAFV600E-mutated cancers.
Relationship of Neural Correlates of Gait Characteristics and Cognitive Dysfunction in Patients with Mild Cognitive Impairment
Authors: Kim Yeo Jin , Park Ingyu , Choi Hui-Chul , Ahn Moo-Eob , Ryu Ohk-Hyun , Jang Daehun , Lee Unjoo , Lee Sang-Kyu
Published: August 2023

Background: Some patients with mild cognitive impairment (MCI) experience gait disturbances. However, there are few reports on the relationship between gait disturbance and cognitive function in patients with MCI. Therefore, we investigated the neural correlates of gait characteristics related to cognitive dysfunction. Methods: Eighty patients diagnosed with MCI from three dementia centers in Gangwon-do, Korea, were recruited for this study. We defined MCI as a Clinical Dementia Rating global score of 0.5 or higher, with a memory domain score of 0.5 or greater. The patients were classified as having either higher or lower MMSE and the groups were based on their Mini Mental Status Examination z-scores. Multiple logistic regression analysis was performed to examine the association between the gait characteristics and cognitive impairment. Analyses included variables such as age, sex, years of education, number of comorbidities, body mass index, and height. Results: Gait velocity, step count, step length, heel-to-heel base support, swing and stance phase duration, and support time were associated with cognitive function. A decrease in gray matter volume in the right pericalcarine area was associated with gait characteristics related to cognitive dysfunction. An increase in the curvature of gray matter in the right entorhinal, right lateral orbitofrontal, right cuneus, and right and left pars opercularis areas was also associated with gait characteristics related to cognitive dysfunction. Conclusion: Since gait impairment is an important factor in determining activities of daily living in patients with mild cognitive impairment, the evaluation of gait and cognitive functions in patients with mild cognitive impairment is important.
Is Histamine and Not Acetylcholine the Missing Link between ADHD and Allergies? Speer Allergic Tension Fatigue Syndrome Re-Visited
Authors: Blasco-Fontecilla Hilario
Published: August 2023

Speer allergic tension-fatigue syndrome (SATFS) is a classic allergy syndrome characterized by allergy-like symptoms, muscle tension, headaches, chronic fatigue, and other particular behaviors that were initially described in the fifties. The particular behaviors displayed include symptoms such as hyperkinesis, hyperesthesia (i.e., insomnia), restlessness, and distractibility, among others. Interestingly, these symptoms are very similar to descriptions of attention deficit hyperactivity disorder (ADHD), the most prevalent neurodevelopmental disorder worldwide, which is characterized by inattention, hyperactivity, and impulsivity. The clinical description of SATFS precedes the nomination of ADHD in 1960 by Stella Chess. In this conceptual paper, we stress that there is a gap in the research on the relationship between ADHD and allergic pathologies. The hypotheses of this conceptual paper are (1) SATFS is probably one of the first and best historical descriptions of ADHD alongside a common comorbidity (allergy) displayed by these patients; (2) SATFS (ADHD) is a systemic disease that includes both somatic and behavioral manifestations that may influence each other in a bidirectional manner; (3) The role of neuroinflammation and histamine is key for understanding the pathophysiology of ADHD and its frequent somatic comorbidities; (4) The deficiency of the diamine oxidase (DAO) enzyme, which metabolizes histamine extracellularly, may play a role in the pathophysiology of ADHD. Decreased DAO activity may lead to an accumulation of histamine, which could contribute to core ADHD symptoms and comorbid disorders. Further empirical studies are needed to confirm our hypotheses.
Is Corticalization in Radiographs Related to a Higher Risk of Bone Loss around Dental Implants in Smoking Patients? A 5-Year Observation of Radiograph Bone-Texture Changes
Authors: Wach Tomasz , Hadrowicz Piotr , Trybek Grzegorz , Michcik Adam , Kozakiewicz Marcin
Published: August 2023

Background: Currently, the topic of dental implants is widely researched. However, still compromising are the factors that can affect implant loss as a consequence of marginal bone loss. One of the factors is smoking, which has a devastating effect on human health and bone structure. Oral health and jaw condition are also negatively affected by smoking. The aim of this study was to evaluate the peri-implant jawbone corticalization phenomenon in tobacco smokers. Methods: A total of 2196 samples from 768 patients with an implant in the neck area were checked, and texture features were analyzed. The corticalization phenomenon was investigated. All analyses were performed in MaZda Software. The influence of corticalization was investigated as a factor on bone structure near the implant neck. The statistical analysis included a feature distribution evaluation, mean (t-test) or median (W-test) comparison, analysis of regression and one-way analysis of variance or Kruskal–Wallis test as no normal distribution or between-group variance was indicated for the significant differences in the investigated groups. Detected differences or relationships were assumed to be statistically significant when p < 0.05. Results: The research revealed that MBL was correlated with smoking after 5 years (0.42 mm ± 1.32 mm 0 mm ± 1.25 mm), the Corticalization Index was higher in the smoker group on the day of surgery, and it became higher after 5y of observation (185.98 ± 90.8 and 243.17 ± 155.47). The implant-loss frequency was higher in the group of smokers, too, compared to non-smokers (6.74% and 2.87%). The higher the torque value during the implant placement, the higher the Corticalization Phenomenon Index. Conclusions: The research revealed a correlation between smoking and changes in bone structure in radio textures near the implants. The corticalization phenomenon is important, may be detected immediately after implant placement and may be one of the indicators of the implant success rate.
Gossypiboma, the Hidden Enemy of an Emergency Cesarean Hysterectomy—Case Report and Review of the Literature
Authors: Varlas Valentin Nicolae , Bors Roxana Georgiana , Mastalier Bogdan , Balescu Irina , Bacalbasa Nicolae , Cirstoiu Monica-Mihaela
Published: August 2023

Gossypiboma or textiloma is a rare medical situation that can complicate the favorable evolution of a surgical case, with repercussions for the patient’s prognosis. The diagnosis can be difficult due to various clinical symptoms, the time elapsed since the surgical intervention, and the imaging often not being precise in detecting textilomas. Due to the medicolegal implications, the reporting of this event is inconsistent. We present a rare case of a 28-year-old woman who presented with vague pain in the left iliac fossa 11 months after an emergency cesarean hysterectomy was performed. The preoperative imaging examination identified the presence of a subhepatic mass with dimensions of 10 × 8 cm2 and another formation in the right iliac fossa with dimensions of 11 × 9 cm2. Exploratory laparotomy found the presence of a large subhepatic gossypiboma, intimately adherent to the hepatic angle of the colon and omentum and a second one adherent to the sigmoid colon, small intestine, and parietal peritoneum. The particularity of this case is given by the simultaneous presence of two textilomas with inconclusive evolution, which can make the differential diagnosis difficult to achieve. For a better assessment of the risk of occurrence of this pathology and the identification of a correct prevention strategy, we performed an extensive search and a review of all the articles published in the PubMed database, identifying 57 articles. In conclusion, emergency surgery increases the risk of this complication, and, as a result, prevention can be achieved by following existing protocols in the operating room.
Does Exercising with the Use of Virtual Reality during Haemodialysis Have an Impact on Plasma Levels of Interleukin 1β, Interleukin 6, and Interleukin 8?
Authors: Turoń-Skrzypińska Agnieszka , Rotter Iwona , Przybyciński Jarosław , Szylińska Aleksandra , Mińko Alicja , Ciechanowski Kazimierz , Dutkiewicz Grażyna
Published: August 2023

Cytokines are a group of fine proteins which play a key role in the regulation of various biological processes, including inflammatory reactions. Proinflammatory cytokines, such as interleukin 1β (IL-1β), interleukin 6 (IL-6), and interleukin 8 (IL-8), are produced in response to various stimuli, including infections, tissue damage, and oxidative stress. Virtual reality (VR) use during intradialytic exercises improves physical activity. The purpose of the study was to evaluate the relationship between exercising regularly with the use of virtual reality during haemodialysis and the levels of selected cytokines (Il-1, Il-6, Il-8). The study and the control groups consisted of end-stage renal disease patients who underwent haemodialysis as a renal replacement treatment. The study group comprised patients subject to haemodialysis as a renal replacement therapy who were to work out with the use of a prototype of the NefroVR system for 20 min when undergoing haemodialysis (HD). Statistical analyses utilised Statistica 13. The conducted research demonstrated that regular exercises with the use of virtual reality might be related to a decrease in inflammation in patients included in the chronic haemodialysis programme. It is key to encourage patients with end-stage renal disease treated with haemodialysis to exercise regularly because of the possibility of their proinflammatory parameters becoming reduced.
Impact of Climate on the Carbon Sink Capacity of Ecological Spaces: A Case Study from the Beijing–Tianjin–Hebei Urban Agglomeration
Authors: Wang Xinyan , Wang Kaiping , Zhang Yunlu , Gao Jingran , Xiong Yiming
Published: August 2023

Climate plays a significant role in shaping ecosystem-level carbon sinks. Research on the mechanisms of climate impacts on carbon sinks can contribute to the achievement of carbon neutrality. Investigating the mechanisms by which climate impact on carbon sinks in ecological spaces in the Beijing–Tianjin–Hebei region, one of the most important urban clusters in China, is of great significance. This study employed spatial autocorrelation and econometric models to explore how various climatic factors impact net primary productivity (which is used to represent carbon sink capacity) on a spatial scale. We found an increasing trend in NPP across the Beijing–Tianjin–Hebei urban agglomeration from 2000 to 2020, with marked spatial clustering. Climatic factors exhibited the best fit with the spatial Durbin model, except for average annual precipitation. The remaining factors had significant effects on NPP, showing spatial spillover effects. Results also showed that the average annual temperature, evaporation, and relative humidity had positive impacts on NPP at a local scale but adverse effects at a regional scale. Average annual sunshine duration and the ground temperature had negative effects on NPP locally but promoted effects regionally. Furthermore, the average annual wind speed negatively impacted both local- and regional-scale NPP. This research provides insights into how climate affects carbon sinks on a small spatial scale, offering important references for making policy decisions and improving the accuracy of carbon cycling simulations.
Surface Treatment of Polymer Membranes for Effective Biofouling Control
Authors: Vishwakarma Vinita , Kandasamy Jaya , Vigneswaran Saravanamuthu
Published: August 2023

Membrane biofouling is the consequence of the deposition of microorganisms on polymer membrane surfaces. Polymeric membranes have garnered more attention for filtering and purifying water because of their ease of handling, low cost, effortless surface modification, and mechanical, chemical, and thermal properties. The sizes of the pores in the membranes enable micro- and nanofiltration, ultrafiltration, and reverse osmosis. Commonly used polymers for water filter membranes are polyvinyl chloride (PVA), polyvinylidene fluoride (PVDF), polyamide (PA), polyethylene glycol (PEG), polyethersulfone (PES), polyimide (PI), polyacrylonitrile (PAN), polyvinyl alcohol (PA), poly (methacrylic acid) (PMAA), polyaniline nanoparticles (PANI), poly (arylene ether ketone) (PAEK), polyvinylidene fluoride polysulfone (PSF), poly (ether imide) (PEI), etc. However, these polymer membranes are often susceptible to biofouling because of inorganic, organic, and microbial fouling, which deteriorates the membranes and minimizes their lives, and increases operating costs. Biofouling infection on polymer membranes is responsible for many chronic diseases in humans. This contamination cannot be eliminated by periodic pre- or post-treatment processes using biocides and other chemicals. For this reason, it is imperative to modify polymer membranes by surface treatments to enhance their efficiency and longevity. The main objective of this manuscript is to discuss application-oriented approaches to control biofouling on polymer membranes using various surface treatment methods, including nanomaterials and fouling characterizations utilizing advanced microscopy and spectroscopy techniques.
Influence of Layer-Thickness Proportions and Their Strength and Elastic Properties on Stress Redistribution during Three-Point Bending of TiB/Ti-Based Two-Layer Ceramics Composites
Authors: Khvostunkov Kirill , Bazhin Pavel , Ni Qing-Qing , Bazhina Arina , Chizhikov Andrey , Konstantinov Alexander
Published: August 2023

A mathematical model was developed to determine the order of failure of layers in a two-layer ceramics composite and to determine the conditions for achieving the maximum limit load under three-point loading. The model was set in the space of three “bilayer parameters”: the ratio of the thickness of the lower layer to the whole thickness of the beam, the ratio of Young’s moduli of the lower layer to the upper layer, and the ratio of flexural strengths of the materials of the lower layer to the upper layer. The adequacy of the model obtained was confirmed by experimental results on the three-point bending of the experimental specimens. The experimental samples were two-layer composites consisting of a cermet layer TiB/Ti and a layer of α-Ti. The samples were obtained by free self-propagating high-temperature synthesis (SHS) compression and with varying their thickness. The results obtained make it possible to predict in advance which layer, based on the specific bilayer parameters, will trigger the brittle fracture mechanism as well as to set the maximum destructive load of bilayer composites.
Single Event Upset Study of 22 nm Fully Depleted Silicon-on-Insulator Static Random Access Memory with Charge Sharing Effect
Authors: Yin Chenyu , Gao Tianzhi , Wei Hao , Chen Yaolin , Liu Hongxia
Published: August 2023

In this paper, the single event effect of 6T-SRAM is simulated at circuit level and device level based on a 22 nm fully depleted silicon-on-insulator (FDSOI) process, and the effects of charge sharing and bipolar amplification are considered in device-level simulation. The results demonstrate that, under the combined influence of these two effects, the circuit’s upset threshold and critical charge decreased by 15.4% and 23.5%, respectively. This indicates that the charge sharing effect exacerbates the single event effects. By analyzing the incident conditions of two different incident radius particles, it is concluded that the particles with a smaller incident radius have a worse impact on the SRAM circuit, and are more likely to cause the single event upset in the circuit, indicating that the ionization distribution generated by the incident particle affects the charge collection.
Combined Temperature Compensation Method for Closed-Loop Microelectromechanical System Capacitive Accelerometer
Authors: Liu Guowen , Liu Yu , Li Zhaohan , Ma Zhikang , Ma Xiao , Wang Xuefeng , Zheng Xudong , Jin Zhonghe
Published: August 2023

This article describes a closed-loop detection MEMS accelerometer for acceleration measurement. This paper analyzes the working principle of MEMS accelerometers in detail and explains the relationship between the accelerometer zero bias, scale factor and voltage reference. Therefore, a combined compensation method is designed via reference voltage source compensation and terminal temperature compensation of the accelerometer, which comprehensively improves the performance over a wide temperature range of the accelerometer. The experiment results show that the initial range is reduced from 3679 ppm to 221 ppm with reference voltage source compensation, zero-bias stability of the accelerometer over temperature is increased by 14.3% on average and the scale factor stability over temperature is increased by 88.2% on average. After combined compensation, one accelerometer zero-bias stability over temperature was reduced to 40 μg and the scale factor stability over temperature was reduced to 16 ppm, the average value of the zero-bias stability over temperature was reduced from 1764 μg to 36 μg, the average value of the scale factor stability over temperature was reduced from 2270 ppm to 25 ppm, the average stability of the zero bias was increased by 97.96% and the average stability of the scale factor was increased by 98.90%.
Different Size Formulations of Fluopyram: Preparation, Antifungal Activity, and Accumulation in the Fungal Pathogen Botrytis cinerea
Authors: Wang Yinmin , Zhang Sida , Xu Yong , Li Haiyun , Zhang Ruihua , Chen Dong , Xu Jianfu , Wu Xuemin
Published: August 2023

Nanotechnology is revolutionizing the efficient production and sustainable development of modern agriculture. Understanding the pesticide activity of both nano- and conventional methods is useful for developing new pesticide formulations. In this study, three solid fluopyram formulations with varying particle sizes were developed, and the mechanisms underlying the difference in the antifungal activity among these formulations were investigated. Wet media milling combined with freeze drying was used to prepare fluopyram nanoparticles (FLU-NS) and a micron-sized solid formulation (FLU-MS), and a jet grinding mill was employed to fabricate fluopyram wettable powder (FLU-WP). The mean particle sizes of FLU-NS, FLU-MS, and FLU-WP were 366.8 nm, 2.99 μm, and 10.16 μm, respectively. Notably, FLU-NS displayed a toxicity index against Botrytis cinerea (gray mold) that was approximately double those of FLU-MS and FLU-WP. Similar trends were noticed in the antifungal tests on Alternaria solani. The uptake of FLU-NS by B. cinerea was approximately twice that of FLU-MS and FLU-WP, indicating that fluopyram nanoparticles are more easily taken up by the pathogen (B. cinerea), and display better bioactivity than the larger fluopyram particles. Therefore, the nanosizing of pesticides appears to be a viable strategy to enhance efficiency without increasing the amount of pesticide used.
Effects of Different Types of Stabilizers on the Properties of Foam Detergent Used for Radioactive Surface Contamination
Authors: Zhang Hao , Liang Lili , Xi Hailing , Lin Xiaoyan , Li Zhanguo , Jiao Yu
Published: August 2023

Compared with high-pressure water and reagent washing decontamination, foam decontamination has a promising application due to its ability to significantly reduce the volume of radioactive waste liquids and effectively decontaminate the inner surface of the pipes, the interior of the large cavities, and the vertical walls. However, the foam is less stable, leading to a low decontamination rate. Currently, three main types of stabilizers with different stabilizing mechanisms, namely nanoparticles, polymers, and cosurfactants, are used to improve foam stability and thus increase the decontamination rate. Nanosilica (NS), xanthan gum (XG), and n-tetradecanol (TD) were used as typical representatives of nanoparticles, polymers, and cosurfactants, respectively, to improve the stability of the foam detergent with pH < 2 and chelating agents. The differences in the effects of these three types of stabilizers on foam properties were investigated. Although NS, XG, and TD all increase the half-life of the foam from 7.2 min to about 40 min, the concentration of TD is much lower than that of NS and XG in the foaming solution, and TD foaming solution has the highest foaming ratio. Moreover, TD can markedly lower the surface tension, resulting in a significant reduction of the wetting contact angle on the surfaces of glass, ceramic tile, stainless steel, and paint, while NS and XG cannot signally change the surface tension and have no obvious effect on the wetting contact angle. At low shear rates, TD can increase the apparent viscosity of foam by two orders of magnitude, and the wall-hanging time of the foam on the vertical wall is more than 30 min. In contrast, NS and XG cause a limited increase in the apparent viscosity of the foam, and the wall-hanging times are both less than 5 min. In addition, TD foaming solution has excellent storage stability, and the storage time has no obvious effect on the performance of the foam. And after only three days of storage, NS undergoes severe agglomeration and precipitation in the foaming solution, resulting in a complete loss of the stabilizing effect. After 90 days of storage, the half-life of XG foam decreases by 26%. For simulated radioactive uranium contamination on both horizontal and vertical surfaces, TD can significantly improve the decontamination rate, especially for vertical surfaces, where TD can increase the single decontamination rate by more than 50%.
Synthesis of PDMS-μ-PCL Miktoarm Star Copolymers by Combinations (Є) of Styrenics-Assisted Atom Transfer Radical Coupling and Ring-Opening Polymerization and Study of the Self-Assembled Nanostructures
Authors: Huang Yi-Shen , Ejeta Dula Daksa , Lin Kun-Yi (Andrew) , Kuo Shiao-Wei , Jamnongkan Tongsai , Huang Chih-Feng
Published: August 2023

Due to their diverse and unique physical properties, miktoarm star copolymers (μ-SCPs) have garnered significant attention. In our study, we employed α-monobomoisobutyryl-terminated polydimethylsiloxane (PDMS-Br) to carry out styrenics-assisted atom transfer radical coupling (SA ATRC) in the presence of 4-vinylbenzyl alcohol (VBA) at 0 °C. By achieving high coupling efficiency (χc = 0.95), we obtained mid-chain functionalized PDMS-VBAm-PDMS polymers with benzylic alcohols. Interestingly, matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF MS) analysis revealed the insertion of only two VBA coupling agents (m = 2). Subsequently, the PDMS-VBA2-PDMS products underwent mid-chain extensions using ε-caprolactone (ε-CL) through ring-opening polymerization (ROP) with an efficient organo-catalyst at 40 °C, resulting in the synthesis of novel (PDMS)2-μ-(PCL)2 μ-SCPs. Eventually, novel (PDMS)2-μ-(PCL)2 μ-SCPs were obtained. The obtained PDMS-μ-PCL μ-SCPs were further subjected to examination of their solid-state self-assembly through small-angle X-ray scattering (SAXS) experiments. Notably, various nanostructures, including lamellae and hexagonally packed cylinders, were observed with a periodic size of approximately 15 nm. As a result, we successfully developed a simple and effective reaction combination (Є) strategy (i.e., SA ATRC-Є-ROP) for the synthesis of well-defined PDMS-μ-PCL μ-SCPs. This approach may open up new possibilities for fabricating nanostructures from siloxane-based materials.
Highly Efficient Ultra-Thin EML Blue PHOLEDs with an External Light-Extraction Diffuser
Authors: Kang Shin-Woo , Bae Eun-Jeong , Park Young-Wook , Ju Byeong-Kwon
Published: August 2023

In this study, various diffusers are applied to highly efficient ultra-thin emission layer (EML) structure-based blue phosphorescent organic light-emitting diodes (PHOLEDs) to improve the electroluminescence (EL) characteristics and viewing angle. To achieve highly efficient blue PHOLEDs, the EL characteristics of ultra-thin EML PHOLEDs with the various diffusers having different structures of pattern–shape (hemisphere/sphere), size (4~75 μm), distribution (surface/embedded), and packing (close-packed/random) were systematically analyzed. The diffusers showed different enhancements in the overall EL characteristics of efficiencies, viewing angle, and others. The EL characteristics showed apparent dependency on their structure. The external quantum efficiency (EQE) was enhanced mainly by following the orders of pattern, size, and shape. Following the pattern size, the EQE enhancement gradually increased; the largest-sized diffuser with a 75 μm closed-packed hemisphere (diffuser-1) showed a 1.47-fold EQE improvement, which was the highest. Meanwhile, the diffuser with a ~7 μm random embedded sphere with a low density (diffuser 5) showed the lowest 1.02-fold-improved EQE. The reference device with ultra-thin EML structure-based blue PHOLEDs showed a maximum EQE of 16.6%, and the device with diffuser 1 achieved a maximum EQE of 24.3% with a 5.1% wider viewing angle compared to the reference device without a diffuser. For the in-depth analysis, the viewing angle profile of the ultra-thin EML PHOLED device and fluorescent green OLEDs were compared. As a result, the efficiency enhancement characteristics of the diffusers show a difference in the viewing angle profile. Finally, the application of the diffuser successfully demonstrated that the EL efficiency and viewing angle could be selectively improved. Additionally, we found that it was possible to realize a wide viewing angle and achieve considerable EQE enhancement by further investigations using high-density and large-sized embedded structures of light-extraction film.
Evaluation of a New ‘Mix-In’ Style Glycomacropeptide-Based Protein Substitute for Food and Drinks in Patients with Phenylketonuria and Tyrosinemia
Authors: Delsoglio Marta , Capener Rebecca , MacDonald Anita , Daly Anne , Ashmore Catherine , Donald Sarah , Gaff Lisa , VanDorp Louise , Skeath Rachel , Ellerton Charlotte , Newby Camille , Dunning Georgina , Dale Clare , Hunjan Inderdip , White Lucy , Allen Heather , Hubbard Gary P. , Stratton Rebecca J.
Published: August 2023

(1) Background: Poor palatability, large volume, and lack of variety of some liquid and powdered protein substitutes (PSs) for patients with phenylketonuria (PKU) and tyrosinemia (TYR) can result in poor adherence. This study aimed to evaluate a new unflavoured, powdered GMP-based PS designed to be mixed into drinks, foods, or with other PSs, in patients with PKU and TYR. (2) Methods: Paediatric and adult community-based patients were recruited from eight metabolic centres and prescribed ≥1 sachet/day (10 g protein equivalent (PE)) of the Mix-In-style PS over 28 days. Adherence, palatability, GI tolerance, and metabolic control were recorded at baseline and follow-up. Patients who completed at least 7 days of intervention were included in the final analysis. (3) Results: Eighteen patients (3–45 years, nine males) with PKU (n = 12) and TYR (n = 6) used the Mix-In-style PS for ≥7 days (mean 26.4 days (SD 4.6), range 11–28 days) alongside their previous PS, with a mean intake of 16.7 g (SD 7.7) PE/day. Adherence was 86% (SD 25), and GI tolerance was stable, with n = 14 experiencing no/no new symptoms and n = 3 showing improved symptoms compared to baseline. Overall palatability was rated satisfactory by 78% of patients, who successfully used the Mix-In-style PS in various foods and drinks, including smoothies, squash, and milk alternatives, as a top-up to meet their protein needs. There was no concern regarding safety/metabolic control during the intervention. (4) Conclusions: The ‘Mix-In’-style PS was well adhered to, accepted, and tolerated. Collectively, these data show that providing a flexible, convenient, and novel format of PS can help with adherence and meet patients’ protein needs.