bluuebunny/crossref_metadata_2025 huggingface dataset:
Knowledge, Attitude, and Associated Factors towards Physical Assessment among Nurses Working in Intensive Care Units: A Multicenter Cross-Sectional Study
Authors: Liyew Bikis , Dejen Tilahun Ambaye , Kassew Tilahun
Published: August 2020

Introduction. Nurses working in the intensive care unit play an essential role in detecting patients at risk of deterioration through ongoing assessment and action in response to changing health status. Objectives. To assess knowledge, attitude, and associated factors towards physical assessment on critically ill patients among nurses working in the intensive care unit at Amhara regional state referral hospitals, Northwest Ethiopia, 2019. The research hypothesis: there is poor physical assessment knowledge, poor physical assessment attitude, and there are factors that are likely to affect nurses’ knowledge and attitude towards physical assessment providing this care to critically ill patients at Amhara regional state referral hospitals, Northwest Ethiopia, 2019. Methods. Institution-based cross-sectional study was conducted among 299 nurses from March to September 2019. A convenience sampling method was used. Data were entered by using Epi Info 7.2.2 and analyzed by using STATA 14. The result was computed by descriptive statistics and to explore predictors of knowledge, and attitude linear regression analysis models were fitted, and the adjusted unstandardized beta (β) coefficient at 95% CI was used. A p-value <0.05 was considered significant. Result and conclusion: the knowledge mean scores were 9.93 ± 2.99 [95% CI (9.59, 10.31)]. The proportion of nurse’s knowledge who score above the mean was 167 (55.9%) [95% CI (50.2, 61.5)] and below the mean 132 (44.1%) [95% CI (38.5, 49.8)]. Attitude means scores were 36.85 ± 6.21 [(36.16, 37.51)]. The proportions of nurse’s attitudes who score above the mean were 158 (52.8%) [95% CI (47.5, 58.5)] and below the mean 141 (47.2) [95% CI (41.5, 52.5)]. Regarding predictor variables, being male [β = 0.84, 95% CI (0.16, 1.52)] and taken training [β = 1.85, 95% CI (1.14, 2.56)] were factors positively associated with knowledge, whereas has taken training [β = 4.13, 95% CI (2.82, 5.44)], total years of experience [β = 0.59, 95% CI (0.25, 0.93)], and knowledge [β = 0.92, 95% CI (0.0.72, 1.12)] were factors positively associated with attitude towards physical assessment. Conclusion. Based on the result of this study, the knowledge and attitude towards physical assessment regarding critically ill patients among nurses working in intensive care units were good. Hence, training, educational support services, and awareness are recommended to encourage nurse’s knowledge and attitude towards physical assessment.
Negative Expression of DSG1 and DSG2, as Prognostic Biomarkers, Impacts on the Overall Survival in Patients with Extrahepatic Cholangiocarcinoma
Authors: Xu Shu , Huang Shengfu , Li Daiqiang , Zou Qiong , Yuan Yuan , Yang Zhulin
Published: August 2020

Aims. To evaluate the expression of DSG1 and DSG2 and investigate their clinicopathological significance in EHCC. Method. The protein expression of DSG1 and DSG2 was measured by EnVision immunohistochemistry in 15 normal biliary tract tissues, 10 biliary tract adenoma tissues, 30 peritumoral tissues, and 100 EHCC tumour tissues. Result. The expression of the DSG1 and DSG2 proteins was significantly lower in EHCC tumour tissues than in normal biliary tract tissues, biliary tract adenoma, and peritumoral tissues (P<0.05). Adenoma and peritumoral tissues with negative DSG1 and/or DSG2 protein expression exhibited atypical hyperplasia. DSG1 expression was positively correlated with DSG2 expression in EHCC (P<0.01). In patients with good differentiation, no invasion, no lymph metastasis, TNM I + II stage, and radical surgery, the positive expression of DSG1 and DSG2 proteins was higher (P<0.05). In comparison to patients with negative DSG1 and/or DSG2 expression, the average overall survival time of those with positive expression was significantly longer (P=0.000). Cox multivariate analysis revealed that negative DSG1 and DSG2 expressions were independent of poor prognosis factors in EHCC patients. The AUC calculated for DSG1 was 0.681 (95% confidence interval: 0.594–0.768) and that for DSG2 was 0.645 (95% confidence interval: 0.555–0.734), while that for DSG1 and DSG2 was 0.772 (95% confidence interval: 0.609-0.936). Conclusions. Negative protein expression of DSG1 and DSG2 is closely related to the pathogenesis, severe clinicopathological characteristics, aggressive biological behaviours, and dismal prognosis in EHCC.
Novel Approaches for Immunosuppression in Graves’ Hyperthyroidism and Associated Orbitopathy
Authors: Lee Alan Chun Hong , Kahaly George J.
Published: August 2020

Background: Both Graves’ hyperthyroidism (GH) and Graves’ orbitopathy (GO) are associated with significant adverse health consequences. All conventional treatment options have limitations regarding efficacy and safety. Most importantly, they do not specifically address the underlying immunological mechanisms. We aim to review the latest development of treatment approaches in these two closely related disorders. Summary: Immunotherapies of GH have recently demonstrated clinical efficacy in preliminary studies. They include ATX-GD-59, an antigen-specific immunotherapy which restores immune tolerance to the thyrotropin receptor; iscalimab, an anti-CD40 monoclonal antibody which blocks the CD40-CD154 costimulatory pathway in B-T cell interaction; and K1-70, a thyrotropin receptor-blocking monoclonal antibody. Novel treatment strategies have also become available in GO. Mycophenolate significantly increased the overall response rate combined with standard glucocorticoid (GC) treatment compared to GC monotherapy. Tocilizumab, an anti-interleukin 6 receptor monoclonal antibody, displayed strong anti-inflammatory action in GC-resistant cases. Teprotumumab, an anti-insulin-like growth factor 1 receptor monoclonal antibody, resulted in remarkable improvement in terms of disease activity, proptosis, and diplopia. Further, rituximab appears to be useful in active disease of recent onset without impending dysthyroid optic neuropathy. Key Messages: Therapeutic advances will continue to optimize our management of GH and associated orbitopathy in an effective and safe manner.
High-Risk Recurrence Basal Cell Carcinoma: Focus on Hedgehog Pathway Inhibitors and Review of the Literature
Authors: Campione Elena , Di Prete Monia , Lozzi Flavia , Lanna Caterina , Spallone Giulia , Mazzeo Mauro , Cosio Terenzio , Rapanotti Cristina , Dika Emi , Gaziano Roberta , Orlandi Augusto , Bianchi Luca
Published: August 2020

Basal cell carcinoma is the most common skin tumour, with the majority of the cases occurring on the head and neck district, where cosmetic and functional results are crucial. It can be locally destructive if not diagnosed early and treated appropriately. Surgery is the treatment of choice for most lesions, but aggressive, recurrent, or unresectable tumours can be challenging to manage. Advanced basal cell carcinoma includes high recurrence risk subtypes, in which standard therapies demonstrate lack of efficacy. This led to a need for investigating more deeply the pathogenesis of the disease and to the discovery of the implication of the hedgehog pathway. The development of systemic inhibitors of this pathway provides new treatment options for patients with advanced disease, resulting in survival improvement. Food and Drug Administration, before, and European Medicines Agency later approved 2 Hedgehog pathway inhibitors for the treatment of advanced basal cell carcinomas, vismodegib and sonidegib. Here, we present a review of the current English language literature trying to analyze differences in the 2 drugs as a head-to-head comparison between them has not already been documented in a randomized controlled clinical trial. Although vismodegib and sonidegib showed similar efficacy and safety profiles, in an indirect comparison scenario, sonidegib has shown slightly better outcomes in locally advanced basal cell carcinoma than vismodegib. They present different molecular structures, as they bind different residues on their targets and develop resistance for different mutations. In a future scenario, clinical trials comparing the 2 drugs are needed, as well as expanding data on discontinuation of therapy and/or consequential administration of them, with the aim to improve our clinical practise.
Terpenes/Terpenoids in Cannabis: Are They Important?
Authors: Hanuš Lumír Ondřej , Hod Yotam
Published: August 2020

Cannabis sativa plant has not only cannabinoids as crucial compounds but also the other compounds that play important role as synergistic and/or entourage compound. Cannabis/hemp plant materials and essential oils were analyzed with the help of gas chromatography/mass spectrometry detector for the content of terpenes and terpenoids. The main terpenes/terpenoids and their abundance in the samples were evaluated. Results of this study will be helpful in the next evaluation of these compound in mixture with cannabinoids and their importance in medical treatment.
Escrevivências da Educação Física cultural
Authors:   Universidade de São Pauo. Faculdade de Educação
Published: August 2020

Escrevivência é uma criação de Conceição Evaristo, escritora, professora e participante ativa do movimento feminista e de valorização da cultura negra, cuja obra ficcional promove um mergulho no universo marginal que a sociedade finge não ver. A escrevivência é um modo de falar, ser ouvido, redigir outra história, outra versão, outra epistemologia, que valoriza o sujeito comum do dia a dia, sobre o qual não se fala porque a ninguém interessa, é a expressão do direito de narrar a si e suas próprias experiências. Negar a alguém o direito de narrar-se é o mesmo que silenciar e desconsiderar seus conhecimentos. É cometer um assassinato epistêmico. Este livro é o inverso disso, trazendo a público relatos de experiências de professoras e professores que afirmam colocar em ação a perspectiva cultural da Educação Física, também chamada currículo cultural, Educação Física culturalmente orientada ou, simplesmente, Educação Física cultural, impossível de ser descrita, e, sendo múltipla e variada, cada autor ou autora deixa transparecer pela escrita toda a força dessa vertente, cujos contornos se modificam no mesmo instante em que é produzida. Produção que nunca cessa, pois é retomada a cada leitura.
Association Between Mental Stress-Induced Inferior Frontal Cortex Activation and Angina in Coronary Artery Disease
Authors: Moazzami Kasra , Wittbrodt Matthew T. , Alkhalaf Mhmtjamil , Lima Bruno B. , Nye Jonathon A. , Mehta Puja K. , Quyyumi Arshed A. , Vaccarino Viola , Bremner J. Douglas , Shah Amit J.
Published: August 2020

Background:

The inferior frontal lobe is an important area of the brain involved in the stress response, and higher activation with acute mental stress may indicate a more severe stress reaction. However, it is unclear if activation of this region with stress correlates with angina in individuals with coronary artery disease.

Methods:

Individuals with stable coronary artery disease underwent acute mental stress testing using a series of standardized speech/arithmetic stressors in conjunction with high resolution positron emission tomography imaging of the brain. Blood flow to the inferior frontal lobe was evaluated as a ratio compared with whole brain flow for each scan. Angina was assessed with the Seattle Angina Questionnaire’s angina frequency subscale at baseline and 2 years follow-up.

Results:

We analyzed 148 individuals with coronary artery disease (mean age [SD] 62 [8] years; 69% male, and 35.8% Black). For every doubling in the inferior frontal lobe activation, angina frequency was increased by 13.7 units at baseline (

, 13.7 [95% CI, 6.3–21.7];
P
=0.008) and 11.6 units during follow-up (

, 11.6 [95% CI, 4.1–19.2];
P
=0.01) in a model adjusted for baseline demographics. Mental stress-induced ischemia and activation of other brain pain processing regions (thalamus, insula, and amygdala) accounted for 40.0% and 13.1% of the total effect of inferior frontal lobe activation on angina severity, respectively.

Conclusions:

Inferior frontal lobe activation with mental stress is independently associated with angina at baseline and during follow-up. Mental stress-induced ischemia and other pain processing brain regions may play a contributory role.
Management of Aortic Stenosis in Patients With End-Stage Renal Disease on Hemodialysis
Authors: Mentias Amgad , Desai Milind Y. , Saad Marwan , Horwitz Phillip A. , Rossen James D. , Panaich Sidakpal , Jneid Hani , Kapadia Samir , Vaughan-Sarrazin Mary
Published: August 2020

Background:

Patients with end-stage renal disease on hemodialysis (ESRD-HD) and aortic stenosis have poor prognosis. The role of transcatheter aortic valve replacement (TAVR) in this high-risk population is debated.

Methods:

We compared the outcomes among ESRD-HD Medicare beneficiaries who were managed with TAVR, surgical AVR (SAVR), or conservative management for aortic stenosis between 2015 and 2017, using overlap propensity score weighting analysis to control for differences in treatment assignment. The primary outcome was all-cause mortality and was compared between treatment groups as well as to age-sex matched mortality for ESRD-HD in the US population. Secondary outcomes included trend of heart failure hospitalizations.

Results:

A total of 8107 ESRD-HD patients with aortic stenosis were included, 4130 (50%) underwent TAVR, 2565 (31.6%) underwent SAVR, and 1412 (17.4%) were managed conservatively. TAVR patients had more comorbidities and higher frailty compared with the other 2 groups. Thirty-day mortality was lower with TAVR compared with SAVR (4.6% versus 12.8%,
P
<0.01). After a median follow-up of 465 days (interquartile range, 261–759), on overlap propensity score weighting analysis, there was no difference in mortality between TAVR and SAVR (adjusted hazard ratio, 1.02 [95% CI, 0.91–1.15],
P
=0.7), and mortality was lower with TAVR compared with conservative management (adjusted hazard ratio, 0.53 [95% CI, 0.47–0.60],
P
<0.001). Standardized mortality ratios with TAVR, SAVR, and conservative management compared with age-sex matched ESRD-HD US population were 1.24, 1.27, and 1.83, respectively. The rate of heart failure admissions declined after TAVR (incidence rate ratio, 0.55 [95% CI, 0.48–0.62],
P
<0.001) and SAVR (incidence rate ratio, 0.76 [95% CI, 0.65–0.88],
P
<0.001).

Conclusions:

In ESRD-HD patients with aortic stenosis, mortality was lower in the short-term with TAVR compared with SAVR but comparable in the mid-term. AVR is associated with an improvement in survival and reduction in heart failure hospitalizations compared with conservative management.
Epigenomic and Transcriptomic Dynamics During Human Heart Organogenesis
Authors: VanOudenhove Jennifer , Yankee Tara N. , Wilderman Andrea , Cotney Justin
Published: August 2020

Rationale:

There is growing evidence that common variants and rare sequence alterations in regulatory sequences can result in birth defects or predisposition to disease. Congenital heart defects are the most common birth defect and have a clear genetic component, yet only a third of cases can be attributed to structural variation in the genome or a mutation in a gene. The remaining unknown cases could be caused by alterations in regulatory sequences.

Objective:

Identify regulatory sequences and gene expression networks that are active during organogenesis of the human heart. Determine whether these sites and networks are enriched for disease-relevant genes and associated genetic variation.

Methods and Results:

We characterized ChromHMM (chromatin state) and gene expression dynamics during human heart organogenesis. We profiled 7 histone modifications in embryonic hearts from each of 9 distinct Carnegie stages (13–14, 16–21, and 23), annotated chromatin states, and compared these maps to over 100 human tissues and cell types. We also generated RNA-sequencing data, performed differential expression, and constructed weighted gene coexpression networks. We identified 177 412 heart enhancers; 12 395 had not been previously annotated as strong enhancers. We identified 92% of all functionally validated heart-positive enhancers (n=281; 7.5× enrichment;
P
<2.2×10
−16
). Integration of these data demonstrated novel heart enhancers are enriched near genes expressed more strongly in cardiac tissue and are enriched for variants associated with ECG measures and atrial fibrillation. Our gene expression network analysis identified gene modules strongly enriched for heart-related functions, regulatory control by heart-specific enhancers, and putative disease genes.

Conclusions:

Well-connected hub genes with heart-specific expression targeted by embryonic heart-specific enhancers are likely disease candidates. Our functional annotations will allow for better interpretation of whole genome sequencing data in the large number of patients affected by congenital heart defects.
Vascular Endothelial Growth Factor 165-Binding Heparan Sulfate Promotes Functional Recovery From Cerebral Ischemia
Authors: Chan Su Jing , Esposito Elga , Hayakawa Kazuhide , Mandaville Emiri , Smith Raymond A.A. , Guo Shuzhen , Niu Wanting , Wong Peter Tsun-Hong , Cool Simon M. , Lo Eng H. , Nurcombe Victor
Published: August 2020

Background and Purpose:

Although VEGF
165
(vascular endothelial growth factor-165) is able to enhance both angiogenesis and neurogenesis, it also increases vascular permeability through the blood-brain barrier. Heparan sulfate (HS) sugars play important roles in regulating VEGF bioactivity in the pericellular compartment. Here we asked whether an affinity-purified VEGF
165
-binding HS (HS7) could augment endogenous VEGF activity during stroke recovery without affecting blood-brain barrier function.

Methods:

Both rat brain endothelial cell line 4 and primary rat neural progenitor cells were used to evaluate the potential angiogenic and neurogenic effects of HS7 in vitro. For in vivo experiments, male Sprague-Dawley rats were subjected to 100 minutes of transient focal cerebral ischemia, then treated after 4 days with either PBS or HS7. One week later, infarct volume, behavioral sequelae, immunohistochemical markers of angiogenesis and neural stem cell proliferation were assessed.

Results:

HS7 significantly enhanced VEGF
165
-mediated angiogenesis in rat brain endothelial cell line 4 brain endothelial cells, and increased the proliferation and differentiation of primary neural progenitor cells, both via the VEGFR2 (vascular endothelial growth factor receptor 2) pathway. Intracerebroventricular injection of HS7 improved neurological outcome in ischemic rats without changing infarct volumes. Immunostaining of the compromised cerebrum demonstrated increases in collagen IV/Ki67 and nestin/Ki67 after HS7 exposure, consistent with its ability to promote angiogenesis and neurogenesis, without compromising blood-brain barrier integrity.

Conclusions:

A VEGF-activating glycosaminoglycan sugar, by itself, is able to enhance endogenous VEGF
165
activity during the post-ischemic recovery phase of stroke.
Dynamic Regional Brain Atrophy Rates in the First Year After Ischemic Stroke
Authors: Brodtmann Amy , Khlif Mohamed Salah , Egorova Natalia , Veldsman Michele , Bird Laura J. , Werden Emilio
Published: August 2020

Background and Purpose:

Brain atrophy can be regarded as an end-organ effect of cumulative cardiovascular risk factors. Accelerated brain atrophy is described following ischemic stroke, but it is not known whether atrophy rates vary over the poststroke period. Examining rates of brain atrophy allows the identification of potential therapeutic windows for interventions to prevent poststroke brain atrophy.

Methods:

We charted total and regional brain volume and cortical thickness trajectories, comparing atrophy rates over 2 time periods in the first year after ischemic stroke: within 3 months (early period) and between 3 and 12 months (later period). Patients with first-ever or recurrent ischemic stroke were recruited from 3 Melbourne hospitals at 1 of 2 poststroke time points: within 6 weeks (baseline) or 3 months. Whole-brain 3T magnetic resonance imaging was performed at 3 time points: baseline, 3 months, and 12 months. Eighty-six stroke participants completed testing at baseline; 125 at 3 months (76 baseline follow-up plus 49 delayed recruitment); and 113 participants at 12 months. Their data were compared with 40 healthy control participants with identical testing. We examined 5 brain measures: hippocampal volume, thalamic volume, total brain and hemispheric brain volume, and cortical thickness. We tested whether brain atrophy rates differed between time points and groups. A linear mixed-effect model was used to compare brain structural changes, including age, sex, years of education, a composite cerebrovascular risk factor score, and total intracranial volume as covariates.

Results:

Atrophy rates were greater in stroke than control participants. Ipsilesional hemispheric, hippocampal, and thalamic atrophy rates were 2 to 4 times greater in the early versus later period.

Conclusions:

Regional atrophy rates vary over the first year after stroke. Rapid brain volume loss in the first 3 months after stroke may represent a potential window for intervention.

Registration:

URL:
https://www.clinicaltrials.gov
. Unique identifier: NCT02205424.
History of Stroke Is Independently Associated With In-Hospital Death in Patients With COVID-19
Authors: Kummer Benjamin R. , Klang Eyal , Stein Laura K. , Dhamoon Mandip S. , Jetté Nathalie
Published: August 2020

Background and Purpose:

In December 2019, an outbreak of severe acute respiratory syndrome coronavirus causing coronavirus disease 2019 (COVID-19) occurred in China, and evolved into a worldwide pandemic. It remains unclear whether the history of cerebrovascular disease is associated with in-hospital death in patients with COVID-19.

Methods:

We conducted a retrospective, multicenter cohort study at Mount Sinai Health System in New York City. Using our institutional data warehouse, we identified all adult patients who were admitted to the hospital between March 1, 2020 and May 1, 2020 and had a positive nasopharyngeal swab polymerase chain reaction test for severe acute respiratory syndrome coronavirus in the emergency department. Using our institutional electronic health record, we extracted clinical characteristics of the cohort, including age, sex, and comorbidities. Using multivariable logistic regression to control for medical comorbidities, we modeled the relationship between history of stroke and all-cause, in-hospital death.

Results:

We identified 3248 patients, of whom 387 (11.9%) had a history of stroke. Compared with patients without history of stroke, patients with a history of stroke were significantly older, and were significantly more likely to have a history of all medical comorbidities except for obesity, which was more prevalent in patients without a history of stroke. Compared with patients without history of stroke, patients with a history of stroke had higher in-hospital death rates during the study period (48.6% versus 31.7%,
P
<0.001). In the multivariable analysis, history of stroke (adjusted odds ratio, 1.28 [95% CI, 1.01–1.63]) was significantly associated with in-hospital death.

Conclusions:

We found that history of stroke was associated with in-hospital death among hospitalized patients with COVID-19. Further studies should confirm these results.
Symbiosis Promotes Fitness Improvements in the Game of Life
Authors: Turney Peter D.
Published: August 2020

We present a computational simulation of evolving entities that includes symbiosis with shifting levels of selection. Evolution by natural selection shifts from the level of the original entities to the level of the new symbiotic entity. In the simulation, the fitness of an entity is measured by a series of one-on-one competitions in the Immigration Game, a two-player variation of Conway's Game of Life. Mutation, reproduction, and symbiosis are implemented as operations that are external to the Immigration Game. Because these operations are external to the game, we can freely manipulate the operations and observe the effects of the manipulations. The simulation is composed of four layers, each layer building on the previous layer. The first layer implements a simple form of asexual reproduction, the second layer introduces a more sophisticated form of asexual reproduction, the third layer adds sexual reproduction, and the fourth layer adds symbiosis. The experiments show that a small amount of symbiosis, added to the other layers, significantly increases the fitness of the population. We suggest that the model may provide new insights into symbiosis in biological and cultural evolution.
Coactivation pattern analysis reveals altered salience network dynamics in children with autism spectrum disorder
Authors: Marshall Emily , Nomi Jason S. , Dirks Bryce , Romero Celia , Kupis Lauren , Chang Catie , Uddin Lucina Q.
Published: August 2020

Brain connectivity studies of autism spectrum disorder (ASD) have historically relied on static measures of functional connectivity. Recent work has focused on identifying transient configurations of brain activity, yet several open questions remain regarding the nature of specific brain network dynamics in ASD. We used a dynamic coactivation pattern (CAP) approach to investigate the salience/midcingulo-insular (M-CIN) network, a locus of dysfunction in ASD, in a large multisite resting-state fMRI dataset collected from 172 children (ages 6–13 years; n = 75 ASD; n = 138 male). Following brain parcellation by using independent component analysis, dynamic CAP analyses were conducted and k-means clustering was used to determine transient activation patterns of the M-CIN. The frequency of occurrence of different dynamic CAP brain states was then compared between children with ASD and typically developing (TD) children. Dynamic brain configurations characterized by coactivation of the M-CIN with central executive/lateral fronto-parietal and default mode/medial fronto-parietal networks appeared less frequently in children with ASD compared with TD children. This study highlights the utility of time-varying approaches for studying altered M-CIN function in prevalent neurodevelopmental disorders. We speculate that altered M-CIN dynamics in ASD may underlie the inflexible behaviors commonly observed in children with the disorder.
The Role of Withholding in the Self-Enforcement of a Value-Added Tax: Evidence from Pakistan
Authors: Waseem Mazhar
Published: August 2020

I leverage the staggered rollout of VAT in Pakistan to document the role of withholding mechanism in the self-enforcement of a VAT. Focusing on firms already in the tax net, I see how their outcomes respond when the tax is extended upward to intermediates used by them. I find that the upward extension of VAT, which triggers the withholding mechanism, causes an immediate and large (more than 40 log points) surge in sales reported by firms. The evolution of bunching above the zero-liability point and of input costs reported by firms suggests that this large response is indeed driven by the withholding mechanism. I also explore the role of withholding in the extensive margin compliance choices of firms.
Peers with Special Needs: Effects and Policies
Authors: Balestra Simone , Eugster Beatrix , Liebert Helge
Published: August 2020

In light of the debate over inclusive education, this paper evaluates the impact of exposure to special needs (SN) peers. More classroom peers with SN lower performance, the probability of entering postcompulsory education, and income at ages 17 to 25. SN students and students at the lower end of the achievement distribution suffer most from higher inclusion. We analyze the effects of reallocation policies to alleviate negative externalities, and demonstrate that inclusion is preferable to segregation in terms of maximizing average test scores.
Lepiota condylospora, a new species with nodulose spores in section Lilaceae from northern Thailand

Authors: SYSOUPHANTHONG PHONGEUN , THONGKLANG NARITSADA , KARUNARATHNA SAMANTHA C. , MORTIMER PETER E. , HYDE KEVIN D. , VELLINGA ELSE C.
Published: August 2020

During our studies of the genus Lepiota in northern Thailand we collected a putatively new species with a distinct morphology and ITS nrDNA profile from Chiang Mai Province. The new species, Lepiota condylospora, is characterized by the presence of reddish brown to brownish orange or brown squamules on the pileus surface, triangular basidiospores with two lateral knobs, and a hymenidermal pileipellis composed of broadly to narrowly clavate elements. Two genetically distinct species of Lepiota section Lilaceae having triangular spores with two lateral knobs are compared with L. condylospora: Lepiota fraterna, from Papua New Guinea, differs in having larger basidiospores and cheilocystidia; while L. cristata var. macrospora, from China, has bigger basidiomata. A full description, color photographs, line drawings and a phylogenetic tree to show the position of the new species are provided.
A reassessment of Eugenia astringens (Myrtaceae) and its synonyms, including their formal typification

Authors: DELPRETE PIERO G.
Published: August 2020

Giovanni Casaretto published Eugenia rotundifolia Casaretto (1842: 40) using material that he collected in Restinga vegetation between Copacabana and Lagoa Rodrigo de Freitas, Rio de Janeiro, Brazil. Berg (1857: 287) treated E. rotundifolia Casaretto as a distinct species, and recognized two varieties. However, the binomial E. rotundifolia (Walker-Arnott 1836: 335) Wight (1841: 17) was previously published for a taxon occurring in Sri Lanka. Therefore, Casaretto’s name is a later superfluous homonym and illegitimate. In a recent article on the typification of plant names published by Casaretto, Delprete et al. (2019) proposed E. casarettoana Delprete (2019: 25) as a substitute name for E. rotundifolia Casaretto. However, Delprete and his collaborators overlooked that the name E. casarettoana O. Berg (1857: 520) was previously published using material collected by Martius near the town of Coari, state of Amazonas, Brazil, and belongs to a distinct species occurring in the Brazilian Amazon. Also, Berg (1857) spelled the specific epithet “casaretteana” without explaining to whom he dedicated the epithet. It is obvious that it was dedicated to Casaretto, as no other botanist or plant collector has a similar last name. Therefore, according to Recommendation 60C of the ICN (Turland et al. 2018), the spelling of this epithet should be corrected to casarettoana, as it has been done for this and other specific epithets dedicated to Casaretto (Delprete 2016).
Aspergillus telluris, a new soil derived species belonging to Aspergillus subgenus Polypaecilum

Authors: SUN BING-DA , HUANG PAN-PAN , WEI HAI-LEI , CAI WEN-JIAO , WANG LIN , LIU SHEN-KUN , JIANG XIAN-ZHI , CHEN AMANDA-JUAN
Published: August 2020

Aspergillus subgenus Polypaecilum contains species with solitary phialides instead of aspergilli and conidia occurring in chains, heads, or singly. Most species in this subgenus are xerotolerant or halotolerant and are widely distributed in house dust and saline environments. Some subgenus Polypaecilum members like Aspergillus caninus and A. chlamydosporus grow well at 37 °C and were associated with mycoses in canines. In the present study, three strains isolated from farmland soil were assigned in subgenus Polypaecilum based on multilocus phylogenetic analyses but showed low sequence similarity with existing species. They were named as a new species, Aspergillus telluris sp. nov.. Aspergillus telluris falls into the A. caninus and A. chlamydosporus clade. Morphologically it is similar to A. chlamydosporus by production of subglobose, pyriform, ellipsoidal conidia and globose to subglobose chlamydospores. This is also the first report of Aspergillus subgenus Polypaecilum species in China.
Shallow-water black corals (Cnidaria: Anthozoa: Hexacorallia: Antipatharia) from SW Madagascar
Authors: TERRANA LUCAS , BO MARZIA , OPRESKO DENNIS M. , EECKHAUT IGOR
Published: August 2020

Antipatharians, also known as black corals, represent a small group of anthozoan hexacorallians found in all oceans of the world. They are generally considered a deep-water taxon; however, some of the most diverse communities are known from tropical shallow waters. With a few poorly detailed exceptions, shallow-water black corals from the Indian Ocean and especially those from Madagascar are mostly unknown. In this study, we report for the first time a highly diverse black coral assemblage of the Western Indian Ocean thriving in shallow waters and upper mesophotic depths (10–52 m depth) along the SW coast of Madagascar. A total of 22 species belonging to six genera (Antipathes, Arachnopathes, Cirrhipathes, Cupressopathes, Myriopathes and Stichopathes) and two families (Antipathidae and Myriopathidae) are described, of which 20 are found in the northern pass of the Great Reef of Toliara, thus representing the most diverse site of the areas investigated. Most of the shallow-water species from the Indian Ocean were originally described more than a century ago, sometimes without being reported again until now. All the descriptions herein rely solely on morphology and include detailed in situ pictures and scanning electron microscope images, in addition to range expansions for many species.
The Extreme El Niño Events Suppressing the Intraseasonal Variability in the Eastern Tropical Indian Ocean
Authors: Chen Gengxin , Wang Dongxiao , Han Weiqing , Feng Ming , Wang Fan , Li Yuanlong , Chen Ju , Gordon Arnold L.
Published: August 2020

In the eastern tropical Indian Ocean, intraseasonal variability (ISV) affects the regional oceanography and marine ecosystems. Mooring and satellite observations documented two periods of unusually weak ISV during the past two decades, associated with suppressed baroclinic instability of the South Equatorial Current. Regression analysis and model simulations suggest that the exceptionally weak ISVs were caused primarily by the extreme El Niño events and modulated to a lesser extent by the Indian Ocean dipole. Additional observations confirm that the circulation balance in the Indo-Pacific Ocean was disrupted during the extreme El Niño events, impacting the Indonesian Throughflow Indian Ocean dynamics. This research provides substantial evidence for large-scale modes modulating ISV and the abnormal Indo-Pacific dynamical connection during extreme climate modes.
Shaping Asia Through Student Mobilities
Authors: Pfaff-Czarnecka Joanna
Published: August 2020

While most Asian students still opt for Western universities when envisioning international destinations, growing numbers turn to Asian countries and their universities. This new development has received increasing attention among practitioners and policy makers, while social science research only recently turned to Asia-to-Asia students’ international flows. This contribution offers, first, a literature review, reflecting on trends and the magnitude of inter-Asian students’ movements. These movements are seen as multiple and complex mobilities, not only in spatial but also in the social and ideational sense. Student strategies in making choices while moving to foreign Asian universities as well as their pathways within the social spaces of universities—paying attention to the multiscalar dimensions of movements and the assemblages they recreate—constitute the second part of the article. The third and main part discusses what we learn about the changing shape of Asia while following students’ pathways and aspirations. These movements shape Asia’s academic space that is embedded in the shifting dimensions of Asian economies, polities, social negotiations, cultures, and values.
Normative collusion in the industry ecosystem: Explaining women’s career pathways and outcomes in investment management
Authors: Cooper Rae , Baird Marian , Foley Meraiah , Oxenbridge Sarah
Published: August 2020

Women are chronically under-represented in investment management, an industry that wields substantial global economic power. This article examines the sources of women’s under-representation, marginalization, and lack of progression within this crucial industry. We demonstrate that norms and practices generated within the industry ecosystem – comprised of industry-specific structures, actors, and interactions – collude to restrict women’s ability to engage with and progress through investment management careers, a process we label normative collusion. Where existing theories have focused on the institutional, organizational, and individual factors that influence women’s career choices and trajectories, our findings demonstrate how industry-level norms and practices can bind organizations to particular modes of operating. To fully understand women’s career pathways and outcomes, particularly at key stages of the life course, we assert that industry-level influences should be incorporated into theoretical models. Foregrounding how normative collusion occurs in the industry ecosystem is an important step, we argue, in understanding women’s career disadvantage, and in designing strategies for change.
COVID-19 Policy-Making in a Country Divided: Catholic Social Teaching as a Path to Unity
Authors: McGovern Thomas W. , Flood Anthony T. , Carson Paul J.
Published: August 2020

Because no vaccines or specific treatments are available, governments around the globe have responded to the Coronavirus Virus Disease 2019 (COVID-19) pandemic with a variety of nonpharmaceutical interventions (NPIs) that include sheltering-in-place orders, social distancing, and school and business closures. While the actual and potential harm due to COVID-19 is far more severe than influenza, the harms due to the NPIs—that have clearly reduced mortality due to COVID-19—are also significant. With government-ordered “lockdowns” across the globe, many arguments for and against returning to normal social and economic activity have been reported, and in fact, Americans are divided about how and when to “open up.” These arguments seem to fall into two major categories. Utilitarianism suggests that suspension of civil liberties and constitutional rights is a necessary response, while Libertarianism supports individual decision-making and greatly reduced government mandates. Protesters around the country have been vocal about one or the other points of view. First, we consider in detail the potential harms of severe acute respiratory syndrome virus-2 (SARS-CoV-2) if left unchecked by NPIs. Second, we look at harms due to restricted social and economic activity on human morbidity and mortality. Finally, we offer a framework based on the four pillars of Catholic Social Teaching and the principle of double effect that offers a more humane solution than Utilitarian or Libertarian principles alone.
Impact of the COVID-19 pandemic on core surgical training
Authors: Khan Khurram Shahzad , Keay Rona , McLellan Morag , Mahmud Sajid
Published: August 2020

Background and aims

COVID-19 pandemic has caused significant disruption in training which is even more pronounced in the surgical specialties. We aim to assess the impact of COVID-19 pandemic on core surgical training.

Methods

All core surgical and improving surgical trainees in West of Scotland region were invited to participate in an online voluntary anonymous survey via SurveyMonkey.

Results

28 of 44 (63.6%) trainees responded, 15 (53.6%) were CT1/ST1. 14 (50.0%) working in teaching hospital and 15 (53.6%) working in general surgery. 20 (71.4%) felt that due to the pandemic they have less opportunity to operate as the primary surgeon. 21 (75.0%) have not attended any outpatient clinics. 8 (28.6%) did not have any form of access to the laparoscopic box-trainer. 20 (71.4%) felt their level of confidence in preforming surgical skills has been negatively impacted. 18 (64.3%) found it difficult to demonstrate progress in portfolio. 21 (75.0%) trainees have not attended any teaching. 10 (35.7%) trainees have been off-sick. 8 (28.6%) trainees have felt slightly or significantly more stressed.

Conclusion

COVID-19 pandemic has an unprecedented negative impact on all aspects of core surgical training. The long term impact on the current cohort of trainees is yet to be seen.
Sex wars and (trans) gender panics: Identity and body politics in contemporary UK feminism
Authors: Hines Sally
Published: August 2020

This article considers how sex and gender – as conceptual categories and as a lived experience – are subject to contestation and renegotiation in the contemporary UK. Exploring gendered shifts through the lenses of identity and embodiment, the article captures key moments where certainties have been undone within feminist and transgender thought and activism. Yet such fissures resound with calls for a return to traditional understandings of the sexed body. The article pays particular attention to debates within feminism around transgender issues, and sketches out a climate of transgender moral panic whereby conservative thinkers and some feminist activists are joining forces with the aim of resurrecting gender binaries.
Whose feminism is it anyway? The unspoken racism of the trans inclusion debate
Authors: Koyama Emi
Published: August 2020

This essay was first published on Emi Koyama’s website eminism.org in 2000. Koyama examines how constructs of universal womanhood have operated to exclude many from feminist spaces. Much of the language surrounding trans identities and bodies has changed in the 20 years since its authorship. Yet, the central tensions, illustrated through a critical account of the Michigan Womyn’s Music Festival’s trans-exclusion policy, remain. Koyama’s powerful argument that ‘no-penis’ policies are inherently racist and classist continues to offer an important challenge to white feminists, be they trans or cis.
Autogynephilia: A scientific review, feminist analysis, and alternative ‘embodiment fantasies’ model
Authors: Serano Julia
Published: August 2020

It is generally accepted within psychology and among trans health providers that transgender people who transition do so because they have a gender identity that is incongruent with their birth-assigned sex, and distinct from their sexual orientation. In contradiction to this standard model, the theory of autogynephilia posits that transgender women’s female gender identities and transitions are merely a by-product of their sexual orientations. While subsequent research has yielded numerous lines of evidence that, taken together, disprove the theory, autogynephilia is still often touted by anti-transgender groups, including trans-exclusionary feminists. Here, I provide an updated overview of the scientific case against autogynephilia. Following that, I will forward an alternative ‘embodiment fantasies’ model that explains all the available findings better than autogynephilia theory, and which is more consistent with contemporary thinking regarding gender and sexual diversity. I will also demonstrate how autogynephilia theory relies on essentialist, heteronormative, and male-centric presumptions about women and LGBTQ+ people, and as such, it is inconsistent with basic tenets of feminism.
More than ‘canaries in the gender coal mine’: A transfeminist approach to research on detransition
Authors: Hildebrand-Chupp Rowan
Published: August 2020

Detransition is tied to three related but distinct concepts – the act of detransitioning, the ‘detransitioner’ identity, and the negative transition experience – which I refer to collectively using the umbrella term ‘detrans’. Detrans research is inevitably political and value-laden, but different methodologies and research questions lend themselves to divergent goals. Drawing on work in the feminist philosophy of science and transfeminist scholarship, I draw a conceptual distinction between research aligned with the goals of ‘preventing detrans’ vs. ‘supporting detrans’. Existing research has constructed detransition as a negative clinical outcome to be prevented because it has been focused on the causes of detrans and the detrans rate. Research associated with the goal of supporting detrans is defined by its focus on the experience and process of detrans itself. Research on preventing detrans constructs detrans as a divisive issue of zero-sum clinical risk, and it is not oriented toward helping people who detransition or who have a negative transition experience. Research on supporting detrans, in contrast, constructs detrans as an issue of inclusion and can be used to improve the medical and mental health care that detrans people receive. I argue that there is an urgent need for qualitative sociological research involving detrans people. I conclude with some broad guidelines for researchers studying detrans.
The toilet debate: Stalling trans possibilities and defending ‘women’s protected spaces’
Authors: Jones Charlotte , Slater Tig
Published: August 2020

As one of the few explicitly gender-separated spaces, the toilet has become a prominent site of conflict and a focal point for ‘gender-critical’ feminism. In this article we draw upon an AHRC-funded project, Around the Toilet, to reflect upon and critique trans-exclusionary and trans-hostile narratives of toilet spaces. Such narratives include ciscentric, heteronormative and gender essentialist positions within toilet research and activism which, for example, equate certain actions and bodily functions (such as menstruation) to a particular gender, decry the need for all-gender toilets, and cast suspicion upon the intentions of trans women in public toilet spaces. These include explicitly transmisogynist discourses perpetuated largely by those calling themselves ‘gender-critical’ feminists, but also extend to national media, right-wing populist discourses and beyond. We use Around the Toilet data to argue that access to safe and comfortable toilets plays a fundamental role in making trans lives possible. Furthermore, we contend that – whether naive, ignorant or explicitly transphobic – trans-exclusionary positions do little to improve toilet access for the majority, instead putting trans people, and others with visible markers of gender difference, at a greater risk of violence, and participating in the dangerous homogenisation of womanhood.
The transfeminist and the liberal institution: A love story
Authors: Bernard Jay
Published: August 2020

As queer owned and operated spaces shut down and we increasingly find ourselves annexed to public institutions and/or private corporate spaces, how do we build truly radical community practices? This piece critically reflects on the practical aspects of organising RadFem/Trans: A Love Story – an event on feminist history and trans inclusion that took place at BFI Flare 2018. It also examines how we might to create the conditions for a better conversation, greater trans inclusion, and deeper organisational thinking.
The ontological woman: A history of deauthentication, dehumanization, and violence
Authors: Williams Cristan
Published: August 2020

Trans-exclusionary radical feminists (TERFs) make use of an ethical, moralistic framework to support specific rhetoric and behavior. Taken together, these form a self-referential ideology that functions to protect an essentialist ontology, which reliably harms cisgender, transgender, and feminist communities. Through an examination of the historical record of US radical feminist and TERF discourses, including first-hand accounts, this article considers how the ontological framework that inspires TERF rhetoric and behavior has functioned as a cycle of moral fulfillment, even as it necessitates the eradication of trans bodies. The article analyzes how TERF morality, rhetoric, and action construct social forms through a sexed binary by relying on an appeal to the natural, which serves to objectify ontological embodiment. It also foregrounds the different historical and contemporary positionalities of trans-exclusionary and trans-inclusive radical feminisms, and concludes with a reminder of the complementary attributes of trans feminism and radical feminism that are evidenced by decades of cooperation.