bluuebunny/crossref_metadata_2025 huggingface dataset:
The traveling salesman problem in bounded degree graphs
Authors: Björklund Andreas , Husfeldt Thore , Kaski Petteri , Koivisto Mikko
Published: April 2012

We show that the traveling salesman problem in bounded-degree graphs can be solved in time
O
((2-ϵ)

n

), where ϵ > 0 depends only on the degree bound but not on the number of cities,
n
. The algorithm is a variant of the classical dynamic programming solution due to Bellman, and, independently, Held and Karp. In the case of bounded integer weights on the edges, we also give a polynomial-space algorithm with running time
O
((2-ϵ)

n

) on bounded-degree graphs. In addition, we present an analogous analysis of Ryser's algorithm for the permanent of matrices with a bounded number of nonzero entries in each column.
On the Relative Strength of Pebbling and Resolution
Authors: Nordström Jakob
Published: April 2012

The last decade has seen a revival of interest in pebble games in the context of proof complexity. Pebbling has proven to be a useful tool for studying resolution-based proof systems when comparing the strength of different subsystems, showing bounds on proof space, and establishing size-space trade-offs. The typical approach has been to encode the pebble game played on a graph as a CNF formula and then argue that proofs of this formula must inherit (various aspects of) the pebbling properties of the underlying graph. Unfortunately, the reductions used here are not tight. To simulate resolution proofs by pebblings, the full strength of nondeterministic black-white pebbling is needed, whereas resolution is only known to be able to simulate deterministic black pebbling. To obtain strong results, one therefore needs to find specific graph families which either have essentially the same properties for black and black-white pebbling (not at all true in general) or which admit simulations of black-white pebblings in resolution.

This article contributes to both these approaches. First, we design a restricted form of black-white pebbling that can be simulated in resolution and show that there are graph families for which such restricted pebblings can be asymptotically better than black pebblings. This proves that, perhaps somewhat unexpectedly, resolution can strictly beat black-only pebbling, and in particular that the space lower bounds on pebbling formulas in Ben-Sasson and Nordström [2008] are tight. Second, we present a versatile parametrized graph family with essentially the same properties for black and black-white pebbling, which gives sharp simultaneous trade-offs for black and black-white pebbling for various parameter settings. Both of our contributions have been instrumental in obtaining the time-space trade-off results for resolution-based proof systems in Ben-Sasson and Nordström [2011].
CS Unplugged and Middle-School Students’ Views, Attitudes, and Intentions Regarding CS
Authors: Taub Rivka , Armoni Michal , Ben-Ari Mordechai
Published: April 2012

Many students hold incorrect ideas and negative attitudes about computer science (CS). In order to address these difficulties, a series of learning activities called Computer Science Unplugged was developed by Tim Bell and his colleagues. These activities expose young people to central concepts in CS in an entertaining way without requiring a computer. The CS Unplugged activities have become more and more popular among CS educators and several activities are recommended in the ACM K-12 curriculum for elementary schools. CS Unplugged is used worldwide and has been translated into many languages.

We examined the effect of the CS Unplugged activities on middle-school students’ ideas about CS and their desire to consider and study it in high school. The results indicate that following the activities the ideas of the students on what CS is about were partially improved, but their desire to study CS lessened.

In order to provide possible explanations to these results, we analyzed the CS Unplugged activities to determine to what extent the objectives of CS Unplugged were addressed in the activities. In addition, we checked whether the activities were designed according to constructivist principles and whether they were explicitly linked to central concepts in CS. We found that only some of the objectives were addressed in the activities, that the activities do not engage with the students’ prior knowledge and that most of the activities are not explicitly linked to central concepts in CS. We offer suggestions for modifying the CS Unplugged activities so that they will be more likely to achieve their objectives.
Robots like us
Authors: Wright Alex
Published: April 2012

Thanks to new research initiatives, autonomous humanoid robots are inching closer to reality.
Programming goes back to school
Authors: Repenning Alexander
Published: April 2012

Broadening participation by integrating game design into middle school curricula.
Efficient system-enforced deterministic parallelism
Authors: Aviram Amittai , Weng Shu-Chun , Hu Sen , Ford Bryan
Published: April 2012

Deterministic execution offers many benefits for debugging, fault tolerance, and security. Current methods of executing
parallel
programs deterministically, however, often incur high costs, allow misbehaved software to defeat repeatability, and transform time-dependent races into input-or path-dependent races without eliminating them. We introduce a new parallel programming model addressing these issues, and use Determinator, a proof-of-concept OS, to demonstrate the model's practicality. Determinator's microkernel application programming interface (API) provides only "shared-nothing" address spaces and deterministic interprocess communication primitives to make execution of all unprivileged code---well-behaved or not---precisely repeatable. Atop this microkernel, Determinator's user-level runtime offers a
private workspace
model for both thread-level and process-level parallel programming. This model avoids the introduction of read/write data races, and converts write/write races into reliably detected conflicts. Coarse-grained parallel benchmarks perform and scale comparably to non-deterministic systems, both on multicore PCs and across nodes in a distributed cluster.
Totally green
Authors: Chang Jichuan , Meza Justin , Ranganathan Parthasarathy , Shah Amip , Shih Rocky , Bash Cullen
Published: April 2012

The environmental impact of servers and datacenters is an important future challenge. System architects have traditionally focused on operational energy as a proxy for designing green servers, but this ignores important environmental implications from server production (materials, manufacturing, etc.). In contrast, this paper argues for a lifecycle focus on the environmental impact of future server designs, to include both operation and production. We present a new methodology to quantify the total environmental impact of system design decisions. Our approach uses the thermodynamic metric of exergy consumption, adapted and validated for use by system architects. Using this methodology, we evaluate the lifecycle impact of several example system designs with environment-friendly optimizations. Our results show that environmental impact from production can be important (around 20% on current servers and growing) and system design choices can reduce this component (by 30--40%). Our results also highlight several, sometimes unexpected, cross-interactions between the environmental impact of production and operation that further motivate a total lifecycle emphasis for future green server designs.
Leveraging stored energy for handling power emergencies in aggressively provisioned datacenters
Authors: Govindan Sriram , Wang Di , Sivasubramaniam Anand , Urgaonkar Bhuvan
Published: April 2012

Datacenters spend $10-25 per watt in provisioning their power infrastructure, regardless of the watts actually consumed. Since peak power needs arise rarely, provisioning power infrastructure for them can be expensive. One can, thus, aggressively under-provision infrastructure assuming that simultaneous peak draw across all equipment will happen rarely. The resulting non-zero probability of emergency events where power needs exceed provisioned capacity, however small, mandates graceful reaction mechanisms to cap the power draw instead of leaving it to disruptive circuit breakers/fuses. Existing strategies for power capping use temporal knobs local to a server that throttle the rate of execution (using power modes), and/or spatial knobs that redirect/migrate excess load to regions of the datacenter with more power headroom. We show these mechanisms to have performance degrading ramifications, and propose an entirely orthogonal solution that leverages existing UPS batteries to temporarily augment the utility supply during emergencies. We build an experimental prototype to demonstrate such power capping on a cluster of 8 servers, each with an individual battery, and implement several online heuristics in the context of different datacenter workloads to evaluate their effectiveness in handling power emergencies. We show that: (i) our battery-based solution can handle emergencies of short duration on its own, (ii) supplement existing reaction mechanisms to enhance their efficacy for longer emergencies, and (iii) battery even provide feasible options when other knobs do not suffice.
Chameleon
Authors: Panneerselvam Sankaralingam , Swift Michael M.
Published: April 2012

The rise of multi-core processors has shifted performance efforts towards parallel programs. However, single-threaded code, whether from legacy programs or ones difficult to parallelize, remains important. Proposed asymmetric multicore processors statically dedicate hardware to improve sequential performance, but at the cost of reduced parallel performance. However, several proposed mechanisms provide the best-of-both-worlds by combining multiple cores into a single, more powerful processor for sequential code. For example, Core Fusion merges multiple cores to pool caches and functional units, and Intel's Turbo Boost raises the clock speed of a core if the other cores on a chip are powered down.

These reconfiguration mechanisms have two important properties. First the set of available cores and their capabilities can vary over short time scales. Current operating systems are not designed for rapidly changing hardware: the existing hotplug mechanisms for reconfiguring processors require global operations and hundreds of milliseconds to complete. Second, configurations may be mutually exclusive: using power to speed one core means it cannot be used to speed another. Current schedulers cannot manage this requirement.

We present Chameleon, an extension to Linux to support dynamic processors that can reconfigure their cores at runtime. Chameleon provides processor proxies to enable rapid reconfiguration, execution objects to abstract the processing capabilities of physical CPUs, and a cluster scheduler to balance the needs of sequential and parallel programs. In experiments that emulate a dynamic processor, we find that Chameleon can reconfigure processors 100,000 times faster than Linux and allows applications full access to hardware capabilities: sequential code runs at full speed on a powerful execution context, while parallel code runs on as many cores as possible.
Execution migration in a heterogeneous-ISA chip multiprocessor
Authors: DeVuyst Matthew , Venkat Ashish , Tullsen Dean M.
Published: April 2012

Prior research has shown that single-ISA heterogeneous chip multiprocessors have the potential for greater performance and energy efficiency than homogeneous CMPs. However, restricting the cores to a single ISA removes an important opportunity for greater heterogeneity. To take full advantage of a heterogeneous-ISA CMP, however, we must be able to migrate execution among heterogeneous cores in order to adapt to program phase changes and changing external conditions (e.g., system power state).

This paper explores migration on heterogeneous-ISA CMPs. This is non-trivial because program state is kept in an architecture-specific form; therefore, state transformation is necessary for migration. To keep migration cost low, the amount of state that requires transformation must be minimized. This work identifies large portions of program state whose form is not critical for performance; the compiler is modified to produce programs that keep most of their state in an architecture-neutral form so that only a small number of data items must be repositioned and no pointers need to be changed. The result is low migration cost with minimal sacrifice of non-migration performance.

Additionally, this work leverages binary translation to enable instantaneous migration. When migration is requested, the program is immediately migrated to a different core where binary translation runs for a short time until a function call is reached, at which point program state is transformed and execution continues natively on the new core.

This system can tolerate migrations as often as every 100 ms and still retain 95% of the performance of a system that does not do, or support, migration.
HICAMP
Authors: Cheriton David , Firoozshahian Amin , Solomatnikov Alex , Stevenson John P. , Azizi Omid
Published: April 2012

Programming language and operating system support for efficient concurrency-safe access to shared data is a key concern for the effective use of multi-core processors. Most research has focused on the software model of multiple threads accessing this data within a single shared address space. However, many real applications are actually structured as multiple separate processes for fault isolation and simplified synchronization. In this paper, we describe the HICAMP architecture and its innovative memory system, which supports efficient concurrency safe access to structured shared data without incurring the overhead of inter-process communication. The HICAMP architecture also provides support for programming language and OS structures such as threads, iterators, read-only access and atomic update. In addition to demonstrating that HICAMP is beneficial for multi-process structured applications, our evaluation shows that the same mechanisms provide substantial benefits for other areas, including sparse matrix computations and virtualization.
Automatic generation of hardware/software interfaces
Authors: King Myron , Dave Nirav , Arvind
Published: April 2012

Enabling new applications for mobile devices often requires the use of specialized hardware to reduce power consumption. Because of time-to-market pressure, current design methodologies for embedded applications require an early partitioning of the design, allowing the hardware and software to be developed simultaneously, each adhering to a rigid interface contract. This approach is problematic for two reasons: (1) a detailed hardware-software interface is difficult to specify until one is deep into the design process, and (2) it prevents the later migration of functionality across the interface motivated by efficiency concerns or the addition of features. We address this problem using the Bluespec Codesign Language~(BCL) which permits the designer to specify the hardware-software partition in the source code, allowing the compiler to synthesize efficient software and hardware along with transactors for communication between the partitions. The movement of functionality across the hardware-software boundary is accomplished by simply specifying a new partitioning, and since the compiler automatically generates the desired interface specifications, it eliminates yet another error-prone design task. In this paper we present BCL, an extension of a commercially available hardware design language (Bluespec SystemVerilog), a new software compiling scheme, and preliminary results generated using our compiler for various hardware-software decompositions of an Ogg Vorbis audio decoder, and a ray-tracing application.
Pancreatic Fistula after Pancreatectomy: Definitions, Risk Factors, Preventive Measures, and Management—Review
Authors: Oneil Machado Norman
Published: April 2012

Resection of pancreas, in particular pancreaticoduodenectomy, is a complex procedure, commonly performed in appropriately selected patients with benign and malignant disease of the pancreas and periampullary region. Despite significant improvements in the safety and efficacy of pancreatic surgery, pancreaticoenteric anastomosis continues to be the “Achilles heel” of pancreaticoduodenectomy, due to its association with a measurable risk of leakage or failure of healing, leading to pancreatic fistula. The morbidity rate after pancreaticoduodenectomy remains high in the range of 30% to 65%, although the mortality has significantly dropped to below 5%. Most of these complications are related to pancreatic fistula, with serious complications of intra-abdominal abscess, postoperative bleeding, and multiorgan failure. Several pharmacological and technical interventions have been suggested to decrease the pancreatic fistula rate, but the results have been controversial. This paper considers definition and classification of pancreatic fistula, risk factors, and preventive approach and offers management strategy when they do occur.
Photocatalytic Activity of Titanate Nanotube Powders in a Hybrid Pollution Control System
Authors: Kim Sun-Jae , Lee Young-Seak , Kim Byung Hoon , Seo Seong-Gyu , Park Sung Hoon , Jung Sang Chul
Published: April 2012

The photocatalytic activity on decomposition of Rhodamine B (RB) of titanate nanotubes (TNTs) synthesized by alkali hydrothermal treatment method was evaluated using a microwave/UV/photocatalyst hybrid system. The effects of each element technique as well as the synergy effects on decomposition of organic material were investigated. When TNTs were ion-exchanged with HCl, Na+content was reduced from 8.36 wt% to 0.03 wt%, whereas the TNTs calcined at 723 K was phase-transformed into anatase structure. The RB decomposition rate increased with TNTs dosage as well as with microwave intensity. Effect of addition of auxiliary oxidants on photocatalytic decomposition of RB was also investigated. When ozone was added, the decomposition rate increased with the amount of ozone added. When H2O2was used as the auxiliary oxidant, however, addition of H2O2exceeding a threshold amount caused reduction of decomposition rate. A synergy effect was observed when H2O2addition was combined with microwave-assisted photocatalysis.
Aerodynamic Losses in Turbines with and without Film Cooling, as Influenced by Mainstream Turbulence, Surface Roughness, Airfoil Shape, and Mach Number
Authors: Ligrani Phil
Published: April 2012

The influences of a variety of different physical phenomena are described as they affect the aerodynamic performance of turbine airfoils in compressible, high-speed flows with either subsonic or transonic Mach number distributions. The presented experimental and numerically predicted results are from a series of investigations which have taken place over the past 32 years. Considered are (i) symmetric airfoils with no film cooling, (ii) symmetric airfoils with film cooling, (iii) cambered vanes with no film cooling, and (iv) cambered vanes with film cooling. When no film cooling is employed on the symmetric airfoils and cambered vanes, experimentally measured and numerically predicted variations of freestream turbulence intensity, surface roughness, exit Mach number, and airfoil camber are considered as they influence local and integrated total pressure losses, deficits of local kinetic energy, Mach number deficits, area-averaged loss coefficients, mass-averaged total pressure loss coefficients, omega loss coefficients, second law loss parameters, and distributions of integrated aerodynamic loss. Similar quantities are measured, and similar parameters are considered when film-cooling is employed on airfoil suction surfaces, along with film cooling density ratio, blowing ratio, Mach number ratio, hole orientation, hole shape, and number of rows of holes.
Novel Aspects of Mevalonate Pathway Inhibitors as Antitumor Agents
Authors: Thurnher Martin , Nussbaumer Oliver , Gruenbacher Georg
Published: April 2012

The mevalonate pathway for cholesterol biosynthesis and protein prenylation has been implicated in various aspects of tumor development and progression. Certain classes of drugs, such as statins and bisphosphonates, inhibit mevalonate metabolism and therefore have also been tested as antitumor agents. This concept is strongly supported by the recent finding that mutant p53, which is present in more than half of all human cancers, can significantly upregulate mevalonate metabolism and protein prenylation in carcinoma cells. The first evidence that mevalonate pathway inhibitors may have the potential to reverse the malignant phenotype has already been obtained. Moreover, recently discovered immunomodulatory properties of statins and bisphosphonates may also contribute to their known anticancer effects. Drug-induced inhibition of protein prenylation may induce sequential cellular stress responses, including the unfolded protein response and autophagy, that eventually translate into inflammasome-dependent and caspase-1-mediated activation of innate immunity. This review focuses on these novel capabilities of mevalonate pathway inhibitors to beneficially affect tumor biology and contribute to tumor immune surveillance. Clin Cancer Res; 18(13); 3524–31. ©2012 AACR.
Somatic Mutations in CCK2R Alter Receptor Activity that Promote Oncogenic Phenotypes
Authors: Willard Melinda D. , Lajiness Mary E. , Wulur Isabella H. , Feng Bo , Swearingen Michelle L. , Uhlik Mark T. , Kinzler Kenneth W. , Velculescu Victor E. , Sjöblom Tobias , Markowitz Sanford D. , Powell Steven M. , Vogelstein Bert , Barber Thomas D.
Published: April 2012

The roles of cholecystokinin 2 receptor (CCK2R) in numerous physiologic processes in the gastrointestinal tract and central nervous system are well documented. There has been some evidence that CCK2R alterations play a role in cancers, but the functional significance of these alterations for tumorigenesis is unknown. We have identified six mutations in CCK2R among a panel of 140 colorectal cancers and 44 gastric cancers. We show that these mutations increase receptor activity, activate multiple downstream signaling pathways, increase cell migration, and promote angiogenesis. Our findings suggest that somatic mutations in CCK2R may promote tumorigenesis through deregulated receptor activity and highlight the importance of evaluating CCK2R inhibitors to block both the normal and mutant forms of the receptor. Mol Cancer Res; 10(6); 739–49. ©2012 AACR.
High-Amylose Resistant Starch Increases Hormones and Improves Structure and Function of the Gastrointestinal Tract: A Microarray Study
Authors: Keenan Michael J. , Martin Roy J. , Raggio Anne M. , McCutcheon Kathleen L. , Brown Ian L. , Birkett Anne , Newman Susan S. , Skaf Jihad , Hegsted Maren , Tulley Richard T. , Blair Eric , Zhou June
Published: April 2012

Background/Aims: Type 2 resistant starch from high-amylose maize (HAM-RS2) is associated with increased fermentation, increased expression of proglucagon (gene for GLP-1) and peptide YY (PYY) genes in the large intestine, and improved health. To determine what other genes are up- or downregulated with feeding of HAM-RS2, a microarray was performed. Methods: Adult, male Sprague Dawley rats were fed one of the following three diets for a 4-week study period: cornstarch control (CC, 3.74 kcal/g), dietary energy density control (EC, 3.27 kcal/g), and 30% HAM-RS2 (RS, 3.27 kcal/g). Rat microarray with ∼27,000 genes and validation of 94 representative genes with multiple qPCR were used to determine gene expression in total RNA extracts of cecal cells from rats. The RS versus EC comparison tested effects of fermentation as energy density of the diet was controlled. Results: For the RS versus EC comparison, 86% of the genes were validated from the microarray and the expression indicates promotion of cell growth, proliferation, differentiation, and apoptosis. Gut hormones GLP-1 and PYY were increased. Conclusions: Gene expression results predict improved structure and function of the GI tract. Production of gut hormones may promote healthy functions beyond the GI tract.
Impact of Progression of Parkinson’s Disease on Drooling in Various Ethnic Groups
Authors: Rana Abdul Qayyum , Yousuf Muhammad Saad , Awan Naeem , Fattah Abdul
Published: April 2012

Background/Aims: Drooling or sialorrhea is a common non-motor symptom of Parkinson’s disease (PD), and is reported by 35–75% of patients. Drooling is primarily due to impaired swallowing rather than hypersecretion of saliva. In this study, we examined the prevalence of drooling in PD and its relation to various factors such as age, stage of disease, gender and ethnicity. Methods: A retrospective cohort chart analysis of 307 patients with idiopathic PD was conducted. These patients were seen in the Parkinson’s Disease and Movement Disorders Clinic between 2005 and 2010. Results: 123 (40%) patients exhibited drooling. No correlation between age and development of drooling was observed. However, gender was found to be a significant factor in developing sialorrhea. Males are twice as more likely to develop sialorrhea than females. In addition, drooling becomes more prevalent with disease progression; Hoehn and Yahr stage 4 patients being the most at risk. Ethnicity and immigration status have no relationship in developing drooling. Conclusions: Sialorrhea is seen in a significant number of PD patients. This study, to the best of our knowledge, is the most extensive clinical assessment of drooling in PD to date.
Local and Systemic Expressions of MMP-9, TIMP-1 and PAI-1 in Patients Undergoing Surgery for Clinically Suspected Appendicitis
Authors: Solberg A. , Holmdahl L. , Falk P. , Wolving M. , Palmgren I. , Ivarsson M.-L.
Published: April 2012

Background/Aims: To examine, compare and correlate the expressions of matrix metalloproteinase 9 (MMP-9), tissue inhibitor of metalloproteinase 1 (TIMP-1) and plasminogen activator inhibitor type 1 (PAI-1) in appendiceal tissue and pre- and postoperative blood samples in patients undergoing surgery for clinically suspected appendicitis. Methods: Fifty-seven patients with complete tissue and blood samples were included and divided into groups of noninflamed appendix/lymphadenitis (n = 7), phlegmonous appendicitis (n = 30), gangrenous appendicitis (n = 11) and perforated appendicitis (n = 9). The protein expressions were assessed with ELISAs. The local expressions of MMP-9, TIMP-1 and PAI-1 were correlated with the systemic expressions at the time of surgery while the systemic individual differences between surgery and recovery were compared. Results: There was a positive correlation between tissue and plasma PAI-1 (p < 0.05). The individual differences for plasma MMP-9 and PAI-1 were statistically nonsignificant, while they were higher for TIMP-1 in patients with perforated appendicitis compared with phlegmonous (p < 0.0001) and gangrenous appendicitis (p < 0.01). Conclusions: Plasma PAI-1 reflected the levels in appendiceal tissue at the time of surgery. Systemic TIMP-1 could have the potential of distinguishing perforated from nonperforated appendicitis.
Mycophenolate as Induction Therapy in Lupus Nephritis with Renal Function Impairment
Authors: Rivera F. , Fulladosa X. , Poveda R. , Frutos M.A. , García-Frías P. , Ara J. , Illescas L. , López-Rubio E. , Mérida E. , Carreño A. , Ballarín J. , Fernández-Juárez G. , Baltar J. , Ramos C. , Pons S. , Oliet A. , Vigil A. , Praga M. , Segarra A. ,   Spanish Group for the Study of Glomerular Disease (GLOSEN)
Published: April 2012

Background: Mycophenolate (MF) is effective as induction therapy for lupus nephritis (LN) in patients with normal renal function; however, little is known about its role in patients with impaired renal failure. The purpose of this study was to evaluate the response to MF in LN and its association with baseline renal function. Methods: Data were obtained for 90 patients from 12 Spanish renal units who were receiving MF as induction therapy for LN. Patients were classified into 2 groups: group 1 (estimated glomerular filtration rate [eGFR] ≥60 ml/min/1.73 m2) and group 2 (eGFR <60 ml/min/ 1.73 m2). The primary outcome measure was the percentage of patients who achieved any response and its relationship with initial eGFR. The secondary outcome measures were the percentage of patients who achieved a complete response (CR) or partial response (PR) and the appearance of relapses during treatment and side effects. Results: At initiation of MF treatment, there were no differences in the main parameters between group 1 (n = 63; eGFR 87 ± 23 ml/min/ 1.73 m2) and group 2 (n = 27; eGFR 44 ± 12 ml/min/1.73 m2). Exposure to prednisone and MF was similar. The percentages of patients who achieved a response in groups 1 and 2 were, respectively, 69.2 and 43.8% at 6 months and 81.3 and 73.7% at 12 months. CR was more frequent in group 1, whereas PR was similar in both groups. Four patients relapsed and side effects were unremarkable. Conclusions: MF is effective and safe as induction therapy for LN, and response is even achieved in patients with baseline renal impairment.
A Comparison of Two Home Exercises for Benign Positional Vertigo: Half Somersault versus Epley Maneuver
Authors: Foster Carol A. , Ponnapan Annand , Zaccaro Kathleen , Strong Darcy
Published: April 2012

Benign paroxysmal positional vertigo (BPPV) frequently recurs after treatment, so a home exercise would be desirable. We designed a self-administered exercise, the half somersault, for home use. In this randomized single-blind study, we compare the efficacy of our exercise to self-administered Epley maneuvers in patients with BPPV. Subjects performed exercises twice while observed, were re-tested with the Dix Hallpike, and then reported on exercise use for 6 months. Outcome measures were the reduction of nystagmus intensity, tolerability of induced dizziness, and long-term efficacy. Both exercises resulted in a significant reduction in nystagmus after two self-applications. The Epley maneuver was significantly more efficacious in reducing nystagmus initially, but caused significantly more dizziness during application than the half somersault. During the 6-month follow-up, the Epley group had significantly more treatment failures than the half somersault group. We believe that both exercises can be self-applied to control symptoms, but the half somersault is tolerated better and has fewer side effects as a home exercise.
Angiogenesis in Neuroendocrine Tumors: Therapeutic Applications
Authors: Scoazec Jean-Yves
Published: April 2012

The considerable research efforts devoted to the understanding of the mechanisms of tumor angiogenesis have resulted in the development of targeted anti-angiogenic therapies and finally in their introduction in clinical practice. Neuroendocrine tumors (NETs), which are characterized by a high vascular supply and a strong expression of VEGF-A, one of the most potent pro-angiogenic factors, are an attractive indication for these new treatments. However, several lines of evidence show that the dense vascular networks associated with low-grade NETs are more likely to be a marker of differentiation than a marker of aggressiveness, as in other epithelial tumors. These observations form the basis for the so-called ‘neuroendocrine paradox’, according to which the most vascularized are the most differentiated and the less angiogenic NETs. This must be kept in mind when discussing the role of anti-angiogenic strategies in the treatment of NETs. Nevertheless, several targeted therapies, with direct or indirect anti-angiogenic properties, including anti-VEGF antibodies, tyrosine kinase inhibitors (sunitinib) and mTOR inhibitors (everolimus), have recently proven to be of clinical benefit. In addition, some drugs already used in NET treatment, such as somatostatin analogues and interferon-α, may also have anti-angiogenic properties. The main challenges for the next future are to validate biomarkers for the selection of patients and the prediction of their response to refine the indications of anti-angiogenic targeted therapies and to overcome the mechanisms of resistance, which explain the limited duration of action of most of these treatments.
Eddy-Resolving Model Estimate of the Cabbeling Effect on the Water Mass Transformation in the Southern Ocean
Authors: Urakawa L. Shogo , Hasumi Hiroyasu
Published: April 2012

Cabbeling effect on the water mass transformation in the Southern Ocean is investigated with the use of an eddy-resolving Southern Ocean model. A significant amount of water is densified by cabbeling: water mass transformation rates are about 4 Sv (1 Sv ≡ 106 m3 s−1) for transformation from surface/thermocline water to Subantarctic Mode Water (SAMW), about 7 Sv for transformation from SAMW to Antarctic Intermediate Water (AAIW), and about 5 Sv for transformation from AAIW to Upper Circumpolar Deep Water. These diapycnal volume transports occur around the Antarctic Circumpolar Current (ACC), where mesoscale eddies are active. The water mass transformation by cabbeling in this study is also characterized by a large amount of densification of Lower Circumpolar Deep Water (LCDW) into Antarctic Bottom Water (AABW) (about 9 Sv). Large diapycnal velocity is found not only along the ACC but also along the coast of Antarctica at the boundary between LCDW and AABW. It is found that about 3 Sv of LCDW is densified into AABW by cabbeling on the continental slopes of Antarctica in this study. This densification is not small compared with observational and numerical estimates on the AABW formation rate, which ranges from 10 to 20 Sv.
Exploring the Micro-Social Geography of Children’s Interactions in Preschool
Authors: Torrens Paul M. , Griffin William A.
Published: April 2012

The authors describe an observational and analytic methodology for recording and interpreting dynamic microprocesses that occur during social interaction, making use of space–time data collection techniques, spatial-statistical analysis, and visualization. The scheme has three investigative foci: Structure, Activity Composition, and Clustering. In each case, these are associated with either acquiring resources or using socioenvironmental features to influence social intercourse. For each point of focus, the authors provide an analytic strategy and demonstration of its usefulness, using data generated from a 2.5-year observational study of young children’s play behavior. Each tool, and its associated concepts, is used to illustrate how early socializing behavior is embedded in time and space. The results show that geography is a significant catalyst for social dynamics in young children: It provides the opportunity for novel interpretations of sociality along with a better understanding of the influence that geographical factors (location, space, place, spatial structure, spatial composition, landmarks, site) have on the evolving reciprocal interplay between individuals and groups.
The Religious Philosophy of Jean Price-Mars
Authors: Joseph Celucien L.
Published: April 2012

Jean Price-Mars was a towering figure in the discipline of Africana studies and a passionate proponent of the revalorization of African retentions in the Black diaspora, especially on Haitian soil. Scholars have identified him as the Francophone counterpart of W. E. B. Du Bois for his activism, scholarly rigor, leadership efficiency, and efforts in the rehabilitation of the Black race. In Haitian thought, he is regarded as the most important Haitian intellectual in the 20th century, having exercised an enduring intellectual influence on the generation of the American occupation in Haiti (1915-1934) and the postoccupation culture from the 1930s to 1970s. While students of Haitian studies and scholars of religion have praised him for his scientific study of the Vodou faith and his intelligent argument for the viability of Vodou as religion, few critics have analyzed the complexity of his religious imagination and ideas. The goal of this essay is to analyze Price-Mars’s engagements with religion beyond the religion of Vodou. Particularly, it will focus on his philosophy of religion and his thought on the nature of belief. The author contends that Price-Mars’s support of cultural relativism theory had shaped his view on religious métissage and religious diversity. The author draws primarily from the religious rhetoric of So Spoke the Uncle and his other works. The author argues to view Price-Mars as a postmodernist religious thinker and a religious syncretist. This essay will show what and how Price-Mars contributed to the disciplines of religion, religious pluralism, and cultural studies and his promotion of religious tolerance.
“Selling the Farm to Buy the Cow”
Authors: Brown Ayanna F. , Lively Janice Tuck
Published: April 2012

This article examines how “Black names” have become a trope for deficit beliefs about Black people in the United States and about Blackness more broadly. In data from two qualitative studies conducted with one group of African American secondary students and second group of African American alumni from a historically black college, participants’ narratives of everyday life reflect the impact of racialization and the extent to which members of both groups attempt to circumvent racialization in their personal and professional lives. The authors identify naming as a cultural right that is threatened within the Black community. They use the principle tenets of Critical Race Theory (CRT) alongside discussions of “race” in a sociolinguistic analysis of participants’ discussions of race and naming. The authors take up CRT’s call for narrative as a critical component for revealing and analyzing the significance and impact of race. Findings from the study illustrate that African Americans struggle with naming and the implications for Black names that influence personal choices they make regardless of their age, education level, and socioeconomic status. There is a consequential aspect to Black names that imposes challenges in refracting the deficit constructions of Blackness that are attached to them.
Differences in Response Bias Among Younger and Older Preschoolers
Authors: Okanda Mako , Somogyi Eszter , Itakura Shoji
Published: April 2012

Groups of children in Japan and Hungary aged 2 to 5 years were asked yes-no questions pertaining to familiar and unfamiliar objects by either strange adults or mothers. In Experiment 1, 3- to 5-year-old Japanese and Hungarian children were interviewed by strange adults, and 3-year-olds in both countries exhibited a yes bias for familiar objects. Japanese 3-year-olds exhibited a yes bias for unfamiliar objects as well. Japanese 4- and 5-year-olds exhibited a yes bias for familiar objects, whereas Hungarian 4- and 5-year-olds exhibited a nay-saying bias for unfamiliar objects. In Experiment 2, Hungarian 2-year-olds exhibited a yes bias for both familiar and unfamiliar objects when asked by strange adults. In Experiment 3, Japanese 3-year-olds exhibited a yes bias for both familiar and unfamiliar objects, whereas 4-year-olds did not exhibit it for familiar objects and exhibited a nay-saying bias for unfamiliar objects when they were asked by mothers. The results suggest that young preschoolers have a common mechanism for exhibiting a yes bias, but older preschoolers may have other reasons to exhibit response biases.
Making the Decision to Move Out
Authors: Lou Evelina , Lalonde Richard N. , Giguère Benjamin
Published: April 2012

The present study examined the impact of culture and family on the issue of moving out among bicultural young adults with European, South Asian, and East Asian backgrounds ( N = 299). Consistent with cross-cultural differences in autonomy ideals, South and East Asians were less motivated than Europeans to leave the family home. Cultural differences in moving out motivation were explained by East and South Asians having less parental approval for moving out before marriage and, additionally for South Asians, having a self-concept that is largely defined by the family (i.e., family allocentrism). Furthermore, the mediating effects of parental approval and family allocentrism were moderated by level of conflict within the family. Implications for understanding cultural demands and family relations with respect to the decision to move out are discussed.
The Better-Than-Average Effect in Hong Kong and the United States
Authors: Tam Kim-Pong , Leung Angela K.- y. , Kim Young-Hoon , Chiu Chi-Yue , Lau Ivy Yee-Man , Au Al K. C.
Published: April 2012

People tend to make self-aggrandizing social comparisons on traits that are important to the self. However, existing research on the better-than-average effect (BTAE) and trait importance does not distinguish between personal trait importance (participants’ ratings of the importance of certain traits to themselves) and cultural trait importance (participants’ perceptions of the importance of the traits to the cultural group to which they belong). We demonstrated the utility of this distinction by examining the joint effects of personal importance and cultural importance on the BTAE among Hong Kong Chinese and American participants. Results showed that the BTAE was more pronounced for personally important traits among both Chinese and American participants. More important, the magnitude of the BTAE was smaller on culturally important traits among Chinese participants only. Chinese participants displayed the strongest BTAE on personally important and culturally unimportant traits, and the smallest BTAE on personally unimportant and culturally important ones. American participants showed the smallest BTAE on personally and culturally unimportant traits. These findings underscore the importance of distinguishing personal trait importance and cultural trait importance in understanding the cultural effects on self-aggrandizing social comparisons. They further suggest that in cultures where people are expected to be modest in self-expression (e.g., Chinese culture), people would avoid claiming superiority on highly culturally important traits even when these traits are important to the self.
A nonlinear, data-driven model applied in the design process of disc-spring valve systems used in hydraulic dampers
Authors: Wszołek Grzegorz , Czop Piotr , Skrobol Antoni , Sławik Damian
Published: April 2012

This paper proposes an analytical tool that supports the design process of a disc-spring valve system used in hydraulic dampers. Such a valve is representative of a broader family of valve systems used in many industrial applications. The tool will speed up the valve-system design process.

The paper considers a valve system that combines a number of circular metal plates, referred to further in the paper as ‘a stack of plates’. The proposed analytical tool obtains a key design characteristic of a valve, the flow rate, and the corresponding maximum stress level in the stack of plates as a function of pressure load. The stress level enables the ranking of valve settings in terms of durability. The calculation process is based on the response of a nonlinear, data-driven model that approximates the a priori simulated cases to cover the complete range of input design parameters, namely the number of plates, their thickness and their diameter. The cases are produced by a first-principle model using a Finite Element (FE) approach. The model was calibrated based on experimental results to provide accurate results in the entire range of input parameters. The advantage of the analytical tool is its ability to immediately provide the pressure-stress-flow characteristic of a valve instead of repeating time-consuming calculations for each new setting of input parameters. The objectives of the paper are as follows: to (a) adapt the model to a three-plate stack by applying large strain theory, (b) select and rank the Artificial Neural Networks used in order to approximate simulation data, and (c) demonstrate validation and application results obtained with the Approximation Tool.
How Not to Save Searle
Authors: D’Amico Robert , Butchard William
Published: April 2012

In response to “‘Counting As’ a Bridge Principle: Against Searle Against Social-Scientific Laws,” Elijah Weber distinguishes two sorts of physical open-endedness and claims our article appeals to the wrong sort. We clarify that Searle’s notion of physical open-endedness is neither of the notions Weber introduces, thus our original reply to Searle is not targeted by Weber’s objections. Also, Weber’s lengthy example concerning counterfeit currency appears to build-in the extremely contentious assumption that scientific laws are impossible if and when relevant conditions do not happen to obtain.
The Influence of Social Categories and Interpersonal Behaviors on Future Intentions and Attitudes to Form Subgroups in Virtual Teams
Authors: Yilmaz Gamze , Peña Jorge
Published: April 2012

Subgroup formation within larger virtual teams can lead to biased information sharing and conflict. Given this, the present study examined how social categories (i.e., in-group vs. out-group status) and interpersonal behaviors (i.e., a teammate behaving positively vs. negatively) influenced intentions and attitudes toward subgrouping in short-term virtual teams. One hundred sixty-four participants interacted in four-person teams using a synchronous chat program. The analysis showed that, though both social categories and interpersonal behaviors affected subgrouping choices, interpersonal behaviors had a stronger effect. Additionally, there was no evidence for the “black sheep hypothesis” predicting that in-group members behaving negatively discourages subgrouping. Overall, this exemplified how minimal categorical cues trigger in-group favoritism and out-group discrimination in virtual teams as anticipated by social identity models. The findings also illustrated how interpersonal behaviors robustly affect virtual team dynamics as stated by social information processing theory.
Halting White Flight
Authors: Henry Elizabeth Egan , Hankins Katherine
Published: April 2012

Focusing on the city of Atlanta from the mid-1970s to the 2000s, this article examines the response of middle- and upper-middle-class white families to the court-ordered desegregation of public schools and growing fears over metropolitan busing. While the majority of white families fled the city and its public schools as part of the growing suburbanization across the Sunbelt, a small number of liberal activists remained committed to integrated public education and formed neighborhood-based organizations to stop white flight. By historicizing this activism, we suggest that the grassroots political response to white flight in the 1970s and the circuits of schooling it produced paved the way for the “return” of white middle- and upper-middle-class families to Atlanta’s public schools by the 2000s.
Managing through Collaborative Networks
Authors: Abels Michael
Published: April 2012

Local governments face a conundrum; a structural decline in revenues concurrent with a complex environment where service responsibility must be viewed as multijurisdictional, multigovernmental, and multisectorial. Issues faced by local government are increasingly beyond the financial or service capacity of individual governments. This article proposes that outcome success in the era of resource limitations necessitates that managers form new systems for regional collaboration. Successful adaption to twenty-first century realities requires that managers lead by identifying and forming new collaborative networks. Networks where several governments, nonprofit, and private organizations will integrate personnel and resources to accomplish a common mission.