bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 1 from Sef Downregulation by Ras Causes MEK1/2 to Become Aberrantly Nuclear Localized Leading to Polyploidy and Neoplastic Transformation
Authors: Duhamel Stéphanie , Hébert Josée , Gaboury Louis , Bouchard Amélie , Simon Ronald , Sauter Guido , Basik Mark , Meloche Sylvain
Published: March 2023

PDF file - 68K
Supplementary Figure 2 from Metabolic Associations of Reduced Proliferation and Oxidative Stress in Advanced Breast Cancer
Authors: Jerby Livnat , Wolf Lior , Denkert Carsten , Stein Gideon Y. , Hilvo Mika , Oresic Matej , Geiger Tamar , Ruppin Eytan
Published: March 2023

PDF file, 427K, MPA example. An example of MPA computation based on a metabolic model and gene-expression or protein abundance measurements. Circular nodes represent metabolites, whereas diamond nodes represent enzymes. For enzymes, gray, red and green represent normal, significantly high and significantly low expression of the enzyme or enzyme-encoding genes, respectively. Similarly, for reactions, those that are predicted as active, inactive or undetermined are colored red, green, or gray, respectively. Solid edges represent metabolic reactions. Broken edges associate enzymes with the reactions they catalyze. The optimal solution obtained for a given sample with (B, D) or without (A, C) the additional constraint to activate the metabolic process of M9 production is shown. The score of the solution is the sum of reactions that are consistent with their expression state, which is what we aim to maximize. The MPA score of a given sample and a metabolic process is then the ratio between the optimal scores obtained with and without the process activity. As each sample has its unique expression profile, different MPA scores are obtained: The M9 production MPA score of sample 1 is smaller than that of sample 2, as its expression is less consistent with M9 production (i.e., enzymes E5 and E7 are lowly expressed).
Supplementary Figure 8 from Sef Downregulation by Ras Causes MEK1/2 to Become Aberrantly Nuclear Localized Leading to Polyploidy and Neoplastic Transformation
Authors: Duhamel Stéphanie , Hébert Josée , Gaboury Louis , Bouchard Amélie , Simon Ronald , Sauter Guido , Basik Mark , Meloche Sylvain
Published: March 2023

PDF file - 284K
Supplementary Figures 1-3 from Dissection of T-cell Antigen Specificity in Human Melanoma
Authors: Andersen Rikke Sick , Thrue Charlotte Albæk , Junker Niels , Lyngaa Rikke , Donia Marco , Ellebæk Eva , Svane Inge Marie , Schumacher Ton N. , thor Straten Per , Hadrup Sine Reker
Published: March 2023

PDF file - 170K
Supplementary Figure Legends 1-3 from 6-Bromoindirubin-3′-Oxime Inhibits JAK/STAT3 Signaling and Induces Apoptosis of Human Melanoma Cells
Authors: Liu Lucy , Nam Sangkil , Tian Yan , Yang Fan , Wu Jun , Wang Yan , Scuto Anna , Polychronopoulos Panos , Magiatis Prokopios , Skaltsounis Leandros , Jove Richard
Published: March 2023

Supplementary Figure Legends 1-3 from 6-Bromoindirubin-3′-Oxime Inhibits JAK/STAT3 Signaling and Induces Apoptosis of Human Melanoma Cells
Supplementary Figure 1 from Oxidation-Mediated DNA Cross-Linking Contributes to the Toxicity of 6-Thioguanine in Human Cells
Authors: Brem Reto , Karran Peter
Published: March 2023

PDF file, 90K, Xanthine oxidase levels in cell lines.
Supplementary Methods, Tables 1-2, Figures 1-4 from Hedgehog Signaling Is a Novel Therapeutic Target in Tamoxifen-Resistant Breast Cancer Aberrantly Activated by PI3K/AKT Pathway
Authors: Ramaswamy Bhuvaneswari , Lu Yuanzhi , Teng Kun-yu , Nuovo Gerard , Li Xiaobai , Shapiro Charles L. , Majumder Sarmila
Published: March 2023

PDF file - 596K, Table S1: Predicted GSK3b phosphorylation sites on SMO. TableS2: Predicted GSK3b phosphorylation sites on SMO. FIG S1: Generation of cell lines resistant to increasing concentration of tamoxifen. FIG S2: Mammosphere formation assay with cells resistant to increasing concentration of tamoxifen. FIG S3: Effect of Gli1 depletion on OHTR and T47D cells. FIG S4: Regulation of GLI1 by PI3k/Akt pathway.
Supplementary Figure Legends 1-7 from RNF8 Regulates Assembly of RAD51 at DNA Double-Strand Breaks in the Absence of BRCA1 and 53BP1
Authors: Nakada Shinichiro , Yonamine Rikako Miyamoto , Matsuo Koichi
Published: March 2023

PDF file - 36K
Supplementary Figure Legends 1-9 from Concomitant Targeting of Tumor Cells and Induction of T-cell Response Synergizes to Effectively Inhibit Trastuzumab-Resistant Breast Cancer
Authors: Wang Qingfei , Li Shau-Hsuan , Wang Hai , Xiao Yi , Sahin Ozgur , Brady Samuel W. , Li Ping , Ge Hailiang , Jaffee Elizabeth M. , Muller William J. , Hortobagyi Gabriel N. , Yu Dihua
Published: March 2023

PDF file - 126K
Supplementary Figure 1 from The SUMO E3-ligase PIAS1 Regulates the Tumor Suppressor PML and Its Oncogenic Counterpart PML-RARA
Authors: Rabellino Andrea , Carter Brandon , Konstantinidou Georgia , Wu Shwu-Yuan , Rimessi Alessandro , Byers Lauren A. , Heymach John V. , Girard Luc , Chiang Cheng-Ming , Teruya-Feldstein Julie , Scaglioni Pier Paolo
Published: March 2023

PDF file - 118K
Supplementary Figure 1 from Notch3 Functions as a Tumor Suppressor by Controlling Cellular Senescence
Authors: Cui Hang , Kong Yahui , Xu Mei , Zhang Hong
Published: March 2023

PDF file - 59K, Data showing shRNA knockdown of Notch3 in telomerase-immortalized cells.
Supplementary Figure 1 from miRNA-130a Targets ATG2B and DICER1 to Inhibit Autophagy and Trigger Killing of Chronic Lymphocytic Leukemia Cells
Authors: Kovaleva Valentina , Mora Rodrigo , Park Yoon Jung , Plass Christoph , Chiramel Abhilash I. , Bartenschlager Ralf , Döhner Hartmut , Stilgenbauer Stephan , Pscherer Armin , Lichter Peter , Seiffert Martina
Published: March 2023

PDF file - 102K
Supplementary Table 3 from Truncated DNMT3B Isoform DNMT3B7 Suppresses Growth, Induces Differentiation, and Alters DNA Methylation in Human Neuroblastoma
Authors: Ostler Kelly R. , Yang Qiwei , Looney Timothy J. , Zhang Li , Vasanthakumar Aparna , Tian Yufeng , Kocherginsky Masha , Raimondi Stacey L. , DeMaio Jessica G. , Salwen Helen R. , Gu Song , Chlenski Alexandre , Naranjo Arlene , Gill Amy , Peddinti Radhika , Lahn Bruce T. , Cohn Susan L. , Godley Lucy A.
Published: March 2023

PDF file, 59K, Differentiation genes altered in DNMT3B7-expressing LA1-55n cells according to RNA Sequencing.
Supplementary Figure Legends 1-9 from Targeting Pioneering Factor and Hormone Receptor Cooperative Pathways to Suppress Tumor Progression
Authors: Shah Supriya , Prasad Shikha , Knudsen Karen E.
Published: March 2023

PDF file - 90K
Supplementary Figure 9 from Targeting Pioneering Factor and Hormone Receptor Cooperative Pathways to Suppress Tumor Progression
Authors: Shah Supriya , Prasad Shikha , Knudsen Karen E.
Published: March 2023

PDF file - 3.5MB
Supplementary Figure 8 from Truncated DNMT3B Isoform DNMT3B7 Suppresses Growth, Induces Differentiation, and Alters DNA Methylation in Human Neuroblastoma
Authors: Ostler Kelly R. , Yang Qiwei , Looney Timothy J. , Zhang Li , Vasanthakumar Aparna , Tian Yufeng , Kocherginsky Masha , Raimondi Stacey L. , DeMaio Jessica G. , Salwen Helen R. , Gu Song , Chlenski Alexandre , Naranjo Arlene , Gill Amy , Peddinti Radhika , Lahn Bruce T. , Cohn Susan L. , Godley Lucy A.
Published: March 2023

PDF file, 56K, Relative DNA methylation by mass spectrometry.
Supplementary Figure 5 from Targeting Pioneering Factor and Hormone Receptor Cooperative Pathways to Suppress Tumor Progression
Authors: Shah Supriya , Prasad Shikha , Knudsen Karen E.
Published: March 2023

PDF file - 1.4MB
Supplementary Figure 2 from Targeting Pioneering Factor and Hormone Receptor Cooperative Pathways to Suppress Tumor Progression
Authors: Shah Supriya , Prasad Shikha , Knudsen Karen E.
Published: March 2023

PDF file - 1.2MB
Supplementary Figure 1 from Targeting Pioneering Factor and Hormone Receptor Cooperative Pathways to Suppress Tumor Progression
Authors: Shah Supriya , Prasad Shikha , Knudsen Karen E.
Published: March 2023

PDF file - 2.1MB
Supplementary Table 4 from RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer
Authors: Patel Ronil A. , Forinash Kara D. , Pireddu Roberta , Sun Ying , Sun Nan , Martin Mathew P. , Schönbrunn Ernst , Lawrence Nicholas J. , Sebti Saïd M.
Published: March 2023

PDF file, 56K, Percent mouse weight change after vehicle treatment. ErbB2 mammary tumor transgenic mice were treated with Vehicle (20% HPCD) as described under Materials and Methods. Final percent change in weight was calculated for each mouse using the following formula; (Wf-W0)/W0*100; where W0= Initial weight (at the beginning of treatment) and Wf= Final weight (at the end of treatment).
Supplementary Table 1 from RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer
Authors: Patel Ronil A. , Forinash Kara D. , Pireddu Roberta , Sun Ying , Sun Nan , Martin Mathew P. , Schönbrunn Ernst , Lawrence Nicholas J. , Sebti Saïd M.
Published: March 2023

PDF file, 64K, Percent tumor volume change after RKI-1447 treatment of ErbB2 mammary tumor transgenic mice. ErbB2 mammary tumor transgenic mice were treated with RKI-1447 as described under Materials and Methods. Percent change in tumor volume was calculated for each tumor using the following formula; (Vf-V0)/V0*100; where V0= Initial volume (at the beginning of treatment) and Vf= Final volume (at the end of treatment).
Supplementary Figure 4 from RKI-1447 Is a Potent Inhibitor of the Rho-Associated ROCK Kinases with Anti-Invasive and Antitumor Activities in Breast Cancer
Authors: Patel Ronil A. , Forinash Kara D. , Pireddu Roberta , Sun Ying , Sun Nan , Martin Mathew P. , Schönbrunn Ernst , Lawrence Nicholas J. , Sebti Saïd M.
Published: March 2023

PDF file, 131K, Molecular mode of action of RKI-1447. Interaction of the ATP site of Rock1 kinase in complex with RKI-1447 determined by X-ray crystallography at 2.9 � resolution. The hinge region is indicated in orange, the DFG motif in cyan, and RKI-1447 in yellow. Displayed in red is the Fo-Fc electron density map contoured at 2.5σ around the RKI-1447 inhibitor which was omitted during refinement. Potential hydrogen bonding and van der Waal interactions are shown as black and green dotted lines, respectively.
Supplementary Figure 2 from Plasmacytoid Dendritic Cells Promote Immunosuppression in Ovarian Cancer via ICOS Costimulation of Foxp3+ T-Regulatory Cells
Authors: Conrad Curdin , Gregorio Josh , Wang Yi-Hong , Ito Tomoki , Meller Stephan , Hanabuchi Shino , Anderson Sonya , Atkinson Neely , Ramirez Pedro T. , Liu Yong-Jun , Freedman Ralph , Gilliet Michel
Published: March 2023

PDF file - 68K, Survival of ICOS+ but not ICOS- T regulatory cells are dependent on ICOS-L provided by plasmacytoid dendritic cells. ICOS+ and ICOS- T regulatory cells isolated from peripheral blood of healthy volunteers were co-cultured with or without autologous plasmacytoid dendritic cells in the presence or absence of neutralizing anti-ICOS-L antibodies as described. Data depicted represent numbers of viable cells after four days of culture. Representative experiment of at least three independent experiments is shown. pDC = plasmacytoid dendritic cells, Treg = T regulatory cells
Supplementary Figure Legends 1-4 from PGC-1α Promotes the Growth of ErbB2/Neu–Induced Mammary Tumors by Regulating Nutrient Supply
Authors: Klimcakova Eva , Chénard Valérie , McGuirk Shawn , Germain David , Avizonis Daina , Muller William J. , St-Pierre Julie
Published: March 2023

PDF file - 80K
Supplementary Methods from Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis
Authors: Satoh Hironori , Moriguchi Takashi , Takai Jun , Ebina Masahito , Yamamoto Masayuki
Published: March 2023

PDF file - 123K
Supplementary Figure 4 from Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis
Authors: Satoh Hironori , Moriguchi Takashi , Takai Jun , Ebina Masahito , Yamamoto Masayuki
Published: March 2023

PDF file - 1030K, Pathway analyses using IPA software.
Supplementary Table 1 from A Preclinical Mouse Model of Invasive Lobular Breast Cancer Metastasis
Authors: Doornebal Chris W. , Klarenbeek Sjoerd , Braumuller Tanya M. , Klijn Christiaan N. , Ciampricotti Metamia , Hau Cheei-Sing , Hollmann Markus W. , Jonkers Jos , de Visser Karin E.
Published: March 2023

PDF file - 30K, Table S1. Detailed information about antibodies and antigen retrieval methods used in immunohistochemical experiments.
Supplementary Methods from A Preclinical Mouse Model of Invasive Lobular Breast Cancer Metastasis
Authors: Doornebal Chris W. , Klarenbeek Sjoerd , Braumuller Tanya M. , Klijn Christiaan N. , Ciampricotti Metamia , Hau Cheei-Sing , Hollmann Markus W. , Jonkers Jos , de Visser Karin E.
Published: March 2023

PDF file - 26K
Supplementary Figure 1 from Nrf2 Prevents Initiation but Accelerates Progression through the Kras Signaling Pathway during Lung Carcinogenesis
Authors: Satoh Hironori , Moriguchi Takashi , Takai Jun , Ebina Masahito , Yamamoto Masayuki
Published: March 2023

PDF file - 1311K, Expression of enzymes involved in the urethane metabolism.
Supplementary Figure 1 from A Preclinical Mouse Model of Invasive Lobular Breast Cancer Metastasis
Authors: Doornebal Chris W. , Klarenbeek Sjoerd , Braumuller Tanya M. , Klijn Christiaan N. , Ciampricotti Metamia , Hau Cheei-Sing , Hollmann Markus W. , Jonkers Jos , de Visser Karin E.
Published: March 2023

PDF file - 1060K, S1. Recipient mice develop pleiomorphic mILCs that are infiltrated by immune cells.
Supplementary Figure 3 from DDX31 Regulates the p53-HDM2 Pathway and rRNA Gene Transcription through Its Interaction with NPM1 in Renal Cell Carcinomas
Authors: Fukawa Tomoya , Ono Masaya , Matsuo Taisuke , Uehara Hisanori , Miki Tsuneharu , Nakamura Yusuke , Kanayama Hiro-omi , Katagiri Toyomasa
Published: March 2023

PDF file - 1MB, Effects of DDX31 knockdown on p53 and p21 expression at the mRNA and protein levels. The cells were harvested and examined by quantitative RT-PCR at 48h (A) and 72h after transfection (B). (C) western blot analysis with the indicated antibodies at 72h after transfection
Supplementary Table 2 from Dermatan Sulfate Is Involved in the Tumorigenic Properties of Esophagus Squamous Cell Carcinoma
Authors: Thelin Martin A. , Svensson Katrin J. , Shi Xiaofeng , Bagher Mariam , Axelsson Jakob , Isinger-Ekstrand Anna , van Kuppevelt Toin H. , Johansson Jan , Nilbert Mef , Zaia Joseph , Belting Mattias , Maccarana Marco , Malmström Anders
Published: March 2023

PDF file - 75K
Supplementary Methods from Dermatan Sulfate Is Involved in the Tumorigenic Properties of Esophagus Squamous Cell Carcinoma
Authors: Thelin Martin A. , Svensson Katrin J. , Shi Xiaofeng , Bagher Mariam , Axelsson Jakob , Isinger-Ekstrand Anna , van Kuppevelt Toin H. , Johansson Jan , Nilbert Mef , Zaia Joseph , Belting Mattias , Maccarana Marco , Malmström Anders
Published: March 2023

PDF file - 84K
Supplementary Figure S2 from Regulation of FANCD2 by the mTOR Pathway Contributes to the Resistance of Cancer Cells to DNA Double-Strand Breaks
Authors: Shen Changxian , Oswald Duane , Phelps Doris , Cam Hakan , Pelloski Christopher E. , Pang Qishen , Houghton Peter J.
Published: March 2023

Supplementary Figure S2 - PDF file 1693K,FANCD2 is Positively Controlled by CDK4. A, Rh30 cells were transfected with siRNAs of control, CDK4, or CDK6. 72 hr later, total proteins were extracted for detection of FANCD2, CDK4, CDK6, pRb-S780 and Rb by immunoblotting. B, Rh30 cells were treated as in A, total RNA was extracted to detect FANCD2 mRNA by real-time RT-PCR with MYCN as internal control. Relative quantity (Ln) of FANCD2 mRNA was plotted
Supplementary Methods, Tables 1-2, Figures 1-3 from MiR-155 Is a Liposarcoma Oncogene That Targets Casein Kinase-1α and Enhances β-Catenin Signaling
Authors: Zhang Pingyu , Bill Katelynn , Liu Juehui , Young Eric , Peng Tingsheng , Bolshakov Svetlana , Hoffman Aviad , Song Yechun , Demicco Elizabeth G. , Terrada Dolores Lopez , Creighton Chad J. , Anderson Matthew L. , Lazar Alexander J. , Calin George G. , Pollock Raphael E. , Lev Dina
Published: March 2023

PDF file - 275K
Supplementary Methods, Figure Legends 1-6, Table Legends 1-3 from RhoJ Regulates Melanoma Chemoresistance by Suppressing Pathways That Sense DNA Damage
Authors: Ho Hsiang , Aruri Jayavani , Kapadia Rubina , Mehr Hootan , White Michael A. , Ganesan Anand K.
Published: March 2023

PDF file - 110K
Supplementary Table 2 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo
Authors: Vicent Silvestre , Sayles Leanne C. , Vaka Dedeepya , Khatri Purvesh , Gevaert Olivier , Chen Ron , Zheng Yanyan , Gillespie Anna K. , Clarke Nicole , Xu Yue , Shrager Joseph , Hoang Chuong D. , Plevritis Sylvia , Butte Atul J. , Sweet-Cordero E. Alejandro
Published: March 2023

XLS file - 27K, Onto-Express Analysis for Functional Pathways
Supplementary Table 1 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo
Authors: Vicent Silvestre , Sayles Leanne C. , Vaka Dedeepya , Khatri Purvesh , Gevaert Olivier , Chen Ron , Zheng Yanyan , Gillespie Anna K. , Clarke Nicole , Xu Yue , Shrager Joseph , Hoang Chuong D. , Plevritis Sylvia , Butte Atul J. , Sweet-Cordero E. Alejandro
Published: March 2023

XLS file - 329K, Microarray Analysis using LIMMA
Supplementary Figure 3 from RhoJ Regulates Melanoma Chemoresistance by Suppressing Pathways That Sense DNA Damage
Authors: Ho Hsiang , Aruri Jayavani , Kapadia Rubina , Mehr Hootan , White Michael A. , Ganesan Anand K.
Published: March 2023

PDF file - 196K, RhoJ Supresses cisplatin-induced Apoptosis in p53 mutant cells by suppresing NBS1 phosphorylation
Supplementary Figure 2 from RhoJ Regulates Melanoma Chemoresistance by Suppressing Pathways That Sense DNA Damage
Authors: Ho Hsiang , Aruri Jayavani , Kapadia Rubina , Mehr Hootan , White Michael A. , Ganesan Anand K.
Published: March 2023

PDF file - 273K, Secondary Validation of siRNA Screen Hits. A. Primary Validation of Hits from siRNA Screen
Supplementary Methods, Figures 1-5 from Phosphorylation of Serine 68 of Twist1 by MAPKs Stabilizes Twist1 Protein and Promotes Breast Cancer Cell Invasiveness
Authors: Hong Jun , Zhou Jian , Fu Junjiang , He Tao , Qin Jun , Wang Li , Liao Lan , Xu Jianming
Published: March 2023

Supplementary Methods, Figures 1-5 from Phosphorylation of Serine 68 of Twist1 by MAPKs Stabilizes Twist1 Protein and Promotes Breast Cancer Cell Invasiveness
Supplementary Figure 1 from Cross-Species Functional Analysis of Cancer-Associated Fibroblasts Identifies a Critical Role for CLCF1 and IL-6 in Non–Small Cell Lung Cancer In Vivo
Authors: Vicent Silvestre , Sayles Leanne C. , Vaka Dedeepya , Khatri Purvesh , Gevaert Olivier , Chen Ron , Zheng Yanyan , Gillespie Anna K. , Clarke Nicole , Xu Yue , Shrager Joseph , Hoang Chuong D. , Plevritis Sylvia , Butte Atul J. , Sweet-Cordero E. Alejandro
Published: March 2023

PDF file - 40K, Lung CAFs stimulate lung cancer growth in vivo
Supplementary Figures 5-7 from Antioxidant Enzymes Mediate Survival of Breast Cancer Cells Deprived of Extracellular Matrix
Authors: Davison Calli A. , Durbin Sienna M. , Thau Matthew R. , Zellmer Victoria R. , Chapman Sarah E. , Diener Justin , Wathen Connor , Leevy W. Matthew , Schafer Zachary T.
Published: March 2023

The expression of antioxidant enzymes is unchanged during ECM-detachment and is comparable between untransformed and transformed cells, The expression of catalase leads to viability changes in the absence of apoptosis, Catalase re-expression rescues ATP levels in catalase-deficient MDA-MB-231 cells.
Supplementary Figure Legends 1-5 from BMK1 Kinase Suppresses Epithelial–Mesenchymal Transition through the Akt/GSK3β Signaling Pathway
Authors: Chen Runqiang , Yang Qingkai , Lee Jiing-Dwan
Published: March 2023

PDF file - 66K
Supplementary Figures 1-6 from Intravesical Delivery of Small Activating RNA Formulated into Lipid Nanoparticles Inhibits Orthotopic Bladder Tumor Growth
Authors: Kang Moo Rim , Yang Glen , Place Robert F. , Charisse Klaus , Epstein-Barash Hila , Manoharan Muthiah , Li Long-Cheng
Published: March 2023

PDF file - 687K, Figure S1. dsP21-322 triggers changes in cell morphology associated with growth inhibition. Figure S2. Anti-growth activities of LNP-dsP21-322-2'F and its non-formulated derivatives. Figure S3. Duplex stability in water and detection of nucleic acid background signal in urine. Figure S4. Uptake of LNP-formulated dsP21-322-2'F-FITC by bladder urothelium. Figure S5. GFP signature of orthotopic tumors in excised mouse bladders. Figure S6. Muscle invasive bladder tumor and metastatic bladder tumor in the kidney
Supplementary Table 1 from Neogenesis of Lymphoid Structures and Antibody Responses Occur in Human Melanoma Metastases
Authors: Cipponi Arcadi , Mercier Marjorie , Seremet Teofila , Baurain Jean-François , Théate Ivan , van den Oord Joost , Stas Marguerite , Boon Thierry , Coulie Pierre G. , van Baren Nicolas
Published: March 2023

PDF file - 49K, List and principal characteristics of antibodies and oligonucleotide primers used in the study
Supplementary Figure 2 from Epithelial-to-Mesenchymal Transition Induced by TGF-β1 Is Mediated by Blimp-1–Dependent Repression of BMP-5
Authors: Romagnoli Mathilde , Belguise Karine , Yu Ziyang , Wang Xiaobo , Landesman-Bollag Esther , Seldin David C. , Chalbos Dany , Barillé-Nion Sophie , Jézéquel Pascal , Seldin Margaret L. , Sonenshein Gail E.
Published: March 2023

PDF file - 168K, Blimp-1 knockdown with siBlimp1-2 represses the migratory properties of MDA-MB-231 breast cancer cells
Supplementary Figure 3 from Inactivation of the HIF-1α/PDK3 Signaling Axis Drives Melanoma toward Mitochondrial Oxidative Metabolism and Potentiates the Therapeutic Activity of Pro-Oxidants
Authors: Kluza Jérome , Corazao-Rozas Paola , Touil Yasmine , Jendoubi Manel , Maire Cyril , Guerreschi Pierre , Jonneaux Aurélie , Ballot Caroline , Balayssac Stéphane , Valable Samuel , Corroyer-Dulmont Aurélien , Bernaudin Myriam , Malet-Martino Myriam , de Lassalle Elisabeth Martin , Maboudou Patrice , Formstecher Pierre , Polakowska Renata , Mortier Laurent , Marchetti Philippe
Published: March 2023

PDF file - 126K, Showing the effect of YC-1 and DCA on PDH activity in A375 and LND cell lines
Supplementary Figure S4 from Extracellular DNA in Pancreatic Cancer Promotes Cell Invasion and Metastasis
Authors: Wen Fushi , Shen Alex , Choi Andrew , Gerner Eugene W. , Shi Jiaqi
Published: March 2023

PDF file - 382K, HPDE-KrasG12D produces exDNA that affect cell migration and invasion
Supplemental Figure S2 from Dynamic Mast Cell–Stromal Cell Interactions Promote Growth of Pancreatic Cancer
Authors: Ma Ying , Hwang Rosa F. , Logsdon Craig D. , Ullrich Stephen E.
Published: March 2023

Supplemental Figure S2 - PDF file 1093K,Cromolyn suppresses Panc-02 PDAC growth in vivo. Tumor size was measured at 21 days after treatment. (A) The mean tumor sizes in the saline-treated and cromolyn-treated groups were 575 and 234 mm3, respectively. A P value of 0.0003 was determined using Student's t-test. Mast cells degranulation in tumor site (arrows) were identified by Toluidine blue staining (B) placebo treated control (C) cromolyn treatment group. Scale bar is 100 �m
Supplementary Figure 1 from Response Classification Based on a Minimal Model of Glioblastoma Growth Is Prognostic for Clinical Outcomes and Distinguishes Progression from Pseudoprogression
Authors: Neal Maxwell Lewis , Trister Andrew D. , Ahn Sunyoung , Baldock Anne , Bridge Carly A. , Guyman Laura , Lange Jordan , Sodt Rita , Cloke Tyler , Lai Albert , Cloughesy Timothy F. , Mrugala Maciej M. , Rockhill Jason K. , Rockne Russell C. , Swanson Kristin R.
Published: March 2023

PDF file - 226K, Supplementary material flowchart as required for mathematical oncology sub-section.
Supplementary Figure 1 from Stem Cell Differentiation and Lumen Formation in Colorectal Cancer Cell Lines and Primary Tumors
Authors: Ashley Neil , Yeung Trevor M. , Bodmer Walter F.
Published: March 2023

PDF file, 363K, Gallery of F-actin labelling of random colonies of various cell lines grown from single cells in Matrigel for 10 days.
Supplementary Table 1 from Epigenetic Regulation by Z-DNA Silencer Function Controls Cancer-Associated ADAM-12 Expression in Breast Cancer: Cross-talk between MeCP2 and NF1 Transcription Factor Family
Authors: Ray Bimal K. , Dhar Srijita , Henry Carolyn , Rich Alexander , Ray Alpana
Published: March 2023

PDF file - 91K, List of cancer-associated genes containing potential Z-DNA elements
Supplementary Figure 3 from Adenomatous Polyps Are Driven by Microbe-Instigated Focal Inflammation and Are Controlled by IL-10–Producing T Cells
Authors: Dennis Kristen L. , Wang Yunwei , Blatner Nichole R. , Wang Shuya , Saadalla Abdulrahman , Trudeau Erin , Roers Axel , Weaver Casey T. , Lee James J. , Gilbert Jack A. , Chang Eugene B. , Khazaie Khashayarsha
Published: March 2023

PDF file, 3099K, Mastocytosis and eosinophilia representative staining in IL-10-deficiency.
Supplementary Figure Legends from Melanoma-Educated CD14+ Cells Acquire a Myeloid-Derived Suppressor Cell Phenotype through COX-2–Dependent Mechanisms
Authors: Mao Yumeng , Poschke Isabel , Wennerberg Erik , Pico de Coaña Yago , Egyhazi Brage Suzanne , Schultz Inkeri , Hansson Johan , Masucci Giuseppe , Lundqvist Andreas , Kiessling Rolf
Published: March 2023

Supplementary Figure Legends - PDF file 90K, Legend for Supplementary Figures S1-S4
Supplementary Tables S1-S2 from PanIN-Specific Regulation of Wnt Signaling by HIF2α during Early Pancreatic Tumorigenesis
Authors: Criscimanna Angela , Duan Li-Juan , Rhodes Julie A. , Fendrich Volker , Wickline Emily , Hartman Douglas J. , Monga Satdarshan P.S. , Lotze Michael T. , Gittes George K. , Fong Guo-Hua , Esni Farzad
Published: March 2023

Supplementary Tables S1-S2 - PDF file 73K, List of primary antibodies, along with the sources and working dilutions (S1); primers used in RT-PCR analyses (S2)
Supplementary Materials and Methods from PanIN-Specific Regulation of Wnt Signaling by HIF2α during Early Pancreatic Tumorigenesis
Authors: Criscimanna Angela , Duan Li-Juan , Rhodes Julie A. , Fendrich Volker , Wickline Emily , Hartman Douglas J. , Monga Satdarshan P.S. , Lotze Michael T. , Gittes George K. , Fong Guo-Hua , Esni Farzad
Published: March 2023

Supplementary Materials and Methods- PDF file 100K, Additional experimental procedures including Generation of Hif2�-floxed mouse line, Tissue processing and Immunostaining, Western Blot, and Small Interfering RNA transfection
SSupplementary Table S2 from Melanoma-Educated CD14+ Cells Acquire a Myeloid-Derived Suppressor Cell Phenotype through COX-2–Dependent Mechanisms
Authors: Mao Yumeng , Poschke Isabel , Wennerberg Erik , Pico de Coaña Yago , Egyhazi Brage Suzanne , Schultz Inkeri , Hansson Johan , Masucci Giuseppe , Lundqvist Andreas , Kiessling Rolf
Published: March 2023

Supplementary Table S2 - PDF file 78K, Supplemental table containing additional antibody information
Supplementary Figure 1 from PanIN-Specific Regulation of Wnt Signaling by HIF2α during Early Pancreatic Tumorigenesis
Authors: Criscimanna Angela , Duan Li-Juan , Rhodes Julie A. , Fendrich Volker , Wickline Emily , Hartman Douglas J. , Monga Satdarshan P.S. , Lotze Michael T. , Gittes George K. , Fong Guo-Hua , Esni Farzad
Published: March 2023

Supplementary Figure 1 - PDF file 2170K, Generation of the Hif2�-floxed strain, and validation of Hif2� inactivation in the pancreas
Supplementary Figures from Cancer Stem–like Cell Marker CD44 Promotes Bone Metastases by Enhancing Tumorigenicity, Cell Motility, and Hyaluronan Production
Authors: Hiraga Toru , Ito Susumu , Nakamura Hiroaki
Published: March 2023

Supplementary Figures - PDF file 1473K, Supplementary Figure S1 Flow cytometric analysis of CD44 expression in the human cancer cell lines, MDA-MB-231 (A, breast cancer), A375 (B, melanoma), PC-3 (C, prostate cancer), HARA-B (D, lung cancer), and MCF-7 (E, breast cancer). Supplementary Figure S2 Flow cytometric analysis of CD44 expression in MDA/shCD44 (A), A375/shCD44 (B), and MCF-7/CD44 (C) clones. CD44-knockdown and -overexpressing clones and the control clones (MDA/shLuc, A375/shLuc, and MCF-7/EV) were labeled with anti-CD44 antibody. The control cells were also labeled with isotype-matched IgG. Supplementary Figure S3 Phenotypes of MCF-7/CD44 clones in vitro and tumor formation in vivo. Supplementary Figure S4 Flow cytometric analysis of the cell surface-associated HA in MDA/shCD44 (A), A375/shCD44 (B) and MCF-7/CD44 (C) clones. MDA/shLuc, A375/shLuc and MCF-7/EV cells labeled without HABP were used as controls. Supplementary Figure S5 Localization of HA and CD44 in bone metastases of A375/shCD44 cells. Supplementary Figure S6 Effects of 4-MU on parental A375 cells in vitro and in vivo. Supplementary Figure S7 Effects of 4-MU on RANKL-induced osteoclast formation in bone marrow cultures. Supplementary Figure S8 Lung metastatic potential of MDA/shCD44 cells. Supplementary Figure S9 Flow cytometric analysis of CD24 and CD44 expression in MDA/shCD44 (A), A375/shCD44 (B), and MCF-7/CD44 (C) cells. Supplementary Figure S10 RT-PCR analysis of standard (arrow, 83 bp) and variant (*) forms of CD44 expression in human cancer cell lines
Supplementary Materials and Methods and Figure Legends from Specific Recruitment of γδ Regulatory T Cells in Human Breast Cancer
Authors: Ye Jian , Ma Chunling , Wang Fang , Hsueh Eddy C. , Toth Karoly , Huang Yi , Mo Wei , Liu Shuai , Han Bing , Varvares Mark A. , Hoft Daniel F. , Peng Guangyong
Published: March 2023

PDF file, 119K.
Supplementary Figure 1 from Specific Recruitment of γδ Regulatory T Cells in Human Breast Cancer
Authors: Ye Jian , Ma Chunling , Wang Fang , Hsueh Eddy C. , Toth Karoly , Huang Yi , Mo Wei , Liu Shuai , Han Bing , Varvares Mark A. , Hoft Daniel F. , Peng Guangyong
Published: March 2023

PDF file, 944K, IP-10 is the only functional chemokine inducing the migration of �� Treg cells.
Supplementary Figure Legend from Therapeutic Effects of Deleting Cancer-Associated Fibroblasts in Cholangiocarcinoma
Authors: Mertens Joachim C. , Fingas Christian D. , Christensen John D. , Smoot Rory L. , Bronk Steven F. , Werneburg Nathan W. , Gustafson Michael P. , Dietz Allan B. , Roberts Lewis R. , Sirica Alphonse E. , Gores Gregory J.
Published: March 2023

PDF file - 101K
Supplementary Figure 6 from Therapeutic Effects of Deleting Cancer-Associated Fibroblasts in Cholangiocarcinoma
Authors: Mertens Joachim C. , Fingas Christian D. , Christensen John D. , Smoot Rory L. , Bronk Steven F. , Werneburg Nathan W. , Gustafson Michael P. , Dietz Allan B. , Roberts Lewis R. , Sirica Alphonse E. , Gores Gregory J.
Published: March 2023

PDF file - 820K, Full length images of all Western blots presented
Supplementary Table S1 from miR-214 Coordinates Melanoma Progression by Upregulating ALCAM through TFAP2 and miR-148b Downmodulation
Authors: Penna Elisa , Orso Francesca , Cimino Daniela , Vercellino Irene , Grassi Elena , Quaglino Elena , Turco Emilia , Taverna Daniela
Published: March 2023

Supplementary Table S1 - PDF file 98K, miR-214 and ALCAM promote melanoma metastasis independently of BRAFV600E mutation status
Supplementary Figure 3 from Therapeutic Effects of Deleting Cancer-Associated Fibroblasts in Cholangiocarcinoma
Authors: Mertens Joachim C. , Fingas Christian D. , Christensen John D. , Smoot Rory L. , Bronk Steven F. , Werneburg Nathan W. , Gustafson Michael P. , Dietz Allan B. , Roberts Lewis R. , Sirica Alphonse E. , Gores Gregory J.
Published: March 2023

PDF file - 59K, Activation of quiescent fibroblasts with TGF-β induces sensitivity to navitoclax cytotoxicity
Supplementary Figure and Table Legends from miR-214 Coordinates Melanoma Progression by Upregulating ALCAM through TFAP2 and miR-148b Downmodulation
Authors: Penna Elisa , Orso Francesca , Cimino Daniela , Vercellino Irene , Grassi Elena , Quaglino Elena , Turco Emilia , Taverna Daniela
Published: March 2023

Supplementary Figure and Table Legends - PDF file 74K, Legend for Supplemental Table S1 and Supplemental Figures S1-S4
Supplementary Figure 4 from CDK1 Phosphorylation of YAP Promotes Mitotic Defects and Cell Motility and Is Essential for Neoplastic Transformation
Authors: Yang Shuping , Zhang Lin , Liu Miao , Chong Rong , Ding Shi-Jian , Chen Yuanhong , Dong Jixin
Published: March 2023

PDF file 162K, Phosphorylation of YAP T119 during Mitosis.
Supplementary Figures from Cyclin D1-Dependent Induction of Luminal Inflammatory Breast Tumors by Activated Notch3
Authors: Ling Hua , Sylvestre Jean-René , Jolicoeur Paul
Published: March 2023

PDF file, 2718K, Figure S1. Expression of Notch target genes in MMTV/N3IC Tg mice ; Figure S2. Analysis of the few MMTV/N3IC Tg CD1 mice from the F85824 founder showing expansion of CD24+ CD29High (R4) mammary cell subsets. ; Figure S3. Characterization of CD24+ CD29Low (R3) cells. ; Figure S4. Effects of cyclin D1 deficiency on CD24+ CD29low (R3) and CD24+ CD29high (R4) mammary cells from MMTV/N3IC Tg mice. ; Figure S5. N3IC-induced tumors contain high percentage of tumor-initiating cells. ; Figure S6. N3IC-induced tumors contain high percentage of tumor-initiating cells.
Supplementary Figure 1 from CDK1 Phosphorylation of YAP Promotes Mitotic Defects and Cell Motility and Is Essential for Neoplastic Transformation
Authors: Yang Shuping , Zhang Lin , Liu Miao , Chong Rong , Ding Shi-Jian , Chen Yuanhong , Dong Jixin
Published: March 2023

PDF file 338K, Identification of Kinase for YAP Phosphorylation.
Supplementary Figure 4 from ATR Inhibition Broadly Sensitizes Ovarian Cancer Cells to Chemotherapy Independent of BRCA Status
Authors: Huntoon Catherine J. , Flatten Karen S. , Wahner Hendrickson Andrea E. , Huehls Amelia M. , Sutor Shari L. , Kaufmann Scott H. , Karnitz Larry M.
Published: March 2023

PDF file - 16K, Supplementary Figure 4. BRCA1 depletion in SKOV3 cells.
Supplementary Video from AC1MMYR2, an Inhibitor of Dicer-Mediated Biogenesis of Oncomir miR-21, Reverses Epithelial–Mesenchymal Transition and Suppresses Tumor Growth and Progression
Authors: Shi Zhendong , Zhang Junxia , Qian Xiaomin , Han Lei , Zhang Kailiang , Chen Luyue , Liu Jilong , Ren Yu , Yang Ming , Zhang Anling , Pu Peiyu , Kang Chunsheng
Published: March 2023

MPG file - 301K, The docking process of compounds from NCI library at the Dicer binding site on pre-miR-21 hairpin loop was presented.
Supplementary Figure 3 from Critical Role of STAT3 in IL-6–Mediated Drug Resistance in Human Neuroblastoma
Authors: Ara Tasnim , Nakata Rie , Sheard Michael A. , Shimada Hiroyuki , Buettner Ralf , Groshen Susan G. , Ji Lingyun , Yu Hua , Jove Richard , Seeger Robert C. , DeClerck Yves A.
Published: March 2023

Supplementary Figure 3 - PDF file 455K, A. CHLA-255 cells were cultures alone or in the presence of sIL-6R (25ng/mL) or IL-6 (10 ng/mL) before being treated with etoposide as indicated in Figure 3. After 24 hours, cells were examined for Annexin V expression by Flow cytometry. The data represents the mean percent of Annexin V positive cells from triplicate samples. B. CHLA-255 and human monocytes were co-cultured as described in figure 6E. Cells were then separated by flow cytometry using anti-GD2 antibody (CHLA-255) and an anti-CD14 (monocytes) and examined for nuclear pSTAT3 by flow cytometry. C. Increased expression of in bone marrow samples from patients with metastatic neuroblastoma. Paraffin-embedded sections of bone marrow biopsies stained by immunohistochemistry of patients without (Left panel) and with (Right panel) tumor cells (scale bar = 50 �m). Increased expression of pSTAT3 and survivin (top) and Bcl-xL (bottom) in bone marrow samples from patients with metastatic neuroblastoma. Left panel, Representative paraffin-embedded sections of bone marrow biopsies from patients, stained by immunohistochemistry for pSTAT3 and survivin of Bcl-xL as indicated in Materials and Methods (scale bar = 50 �m). Right panel, The graph represents the mean number (�SD) of pSTAT3 and survivin positive cells in five 40x fields examined in bone marrow without (n=5) and with (n=5) tumor cells
Supplementary Figure Legend from Neuropilin-2 Is Upregulated in Lung Cancer Cells during TGF-β1–Induced Epithelial–Mesenchymal Transition
Authors: Nasarre Patrick , Gemmill Robert M. , Potiron Vincent A. , Roche Joëlle , Lu Xian , Barón Anna E. , Korch Christopher , Garrett-Mayer Elizabeth , Lagana Alessandro , Howe Philip H. , Drabkin Harry A.
Published: March 2023

PDF file - 120K
Supplementary Figures 1 - 5, Tables 1 - 9 from A Novel Algorithm for Simplification of Complex Gene Classifiers in Cancer
Authors: Wilson Raphael A. , Teng Ling , Bachmeyer Karen M. , Bissonnette Mei Lin Z. , Husain Aliya N. , Parham David M. , Triche Timothy J. , Wing Michele R. , Gastier-Foster Julie M. , Barr Frederic G. , Hawkins Douglas S. , Anderson James R. , Skapek Stephen X. , Volchenboum Samuel L.
Published: March 2023

PDF file - 714K, Supplementary Figure 1 Two-gene combinations from the 50-gene F1/F2 classifier with >98% classification efficiency in the Williamson data set. Supplementary Figure 2 Thirteen two-gene combinations with >99% classification efficiency, identified from exhaustive analysis of top 2000 genes. Supplementary Figure 3 Gene dyads with classification efficiency >95% identified through exhaustive search of all possible combinations. Supplementary Figure 4 Detection of gene expression is comparable for fresh-frozen and paraformaldehyde-fixed material with nCounter. Supplementary Figure 5 Gene expression detected in each case with the Williamson F1/F2 metagene nCounter Code set. Supplementary Table 1 Four-gene combinations with ≥ 99% accuracy. Supplementary Table 2 Dyad classifiers from T-test ranking of Williamson data set with ≥ 98% accuracy, applied to Davicioni data. Supplementary Table 3 T-test dyad classifier genes found in F1/F2 metagenes (L) and F1/F2 metagene probes excluded from dyad pairs (R). Supplementary Table 4 Top-scoring classifiers from exhaustive search of 1.5 billion gene pairs from Williamson data set, also applied to Davicioni and Exon data. Supplementary Table 5 Tumor sample characteristics. Supplementary Table 6 Genes in nCounter set. Supplementary Table 7 PCA Scores by tumor sample for nCounter Data. Supplementary Table 8 CA Loadings for nCounter Data. Supplementary Table 9 Top-scoring nCounter dyad classifiers. Supplementary Table 10 Top gene combinations - Lung cancer data
Supplementary Figure 5 from Elevated ALCAM Shedding in Colorectal Cancer Correlates with Poor Patient Outcome
Authors: Hansen Amanda G. , Freeman Tanner J. , Arnold Shanna A. , Starchenko Alina , Jones-Paris Celestial R. , Gilger Michael A. , Washington Mary K. , Fan Kang-Hsien , Shyr Yu , Beauchamp Robert D. , Zijlstra Andries
Published: March 2023

Supplementary Figure 5 PDF file 1990K, Supplemental Figure 5: The image processing pipeline implemented using FIJI
Supplementary Figure 4 from Elevated ALCAM Shedding in Colorectal Cancer Correlates with Poor Patient Outcome
Authors: Hansen Amanda G. , Freeman Tanner J. , Arnold Shanna A. , Starchenko Alina , Jones-Paris Celestial R. , Gilger Michael A. , Washington Mary K. , Fan Kang-Hsien , Shyr Yu , Beauchamp Robert D. , Zijlstra Andries
Published: March 2023

Supplementary Figure 4 PDF file 333K, Supplemental Figure 4: The specificity of anti-ALCAM ICD confirmed by analysis of ALCAM in ALCAM-/- mice
Supplementary Video 2 from Integrin αvβ3 and Fibronectin Upregulate Slug in Cancer Cells to Promote Clot Invasion and Metastasis
Authors: Knowles Lynn M. , Gurski Lisa A. , Engel Charlotte , Gnarra James R. , Maranchie Jodi K. , Pilch Jan
Published: March 2023

WMV file, 11607K, MDA-MB-231 in 3D fibrin.
Supplementary Figure 1 from Targeting ERBB Receptors Shifts Their Partners and Triggers Persistent ERK Signaling through a Novel ERBB/EFNB1 Complex
Authors: Vermeer Paola D. , Colbert Paul L. , Wieking Bryant G. , Vermeer Daniel W. , Lee John H.
Published: March 2023

PDF file, 68K, Primary murine tonsil epithelia (1oMTE), MTEs stably expressing HPV16 E6 and E7 together with Ras and luciferase (MEERL), were analyzed by western blot as indicated.
Supplementary Video 1 from Integrin αvβ3 and Fibronectin Upregulate Slug in Cancer Cells to Promote Clot Invasion and Metastasis
Authors: Knowles Lynn M. , Gurski Lisa A. , Engel Charlotte , Gnarra James R. , Maranchie Jodi K. , Pilch Jan
Published: March 2023

WMV file, 12420K, 786-0 in 3D fibrin.
Supplementary Table 2 from Quantitative In Vivo Characterization of Intracellular and Extracellular pH Profiles in Heterogeneous Tumors: A Novel Method Enabling Multiparametric pH Analysis
Authors: Lutz Norbert W. , Le Fur Yann , Chiche Johanna , Pouysségur Jacques , Cozzone Patrick J.
Published: March 2023

PDF file - 79K, Statistical parameters characterizing unimodal computer-simulated pH distributions.
Supplementary Table 1 from VEGFA-VEGFR Pathway Blockade Inhibits Tumor-Induced Regulatory T-cell Proliferation in Colorectal Cancer
Authors: Terme Magali , Pernot Simon , Marcheteau Elie , Sandoval Federico , Benhamouda Nadine , Colussi Orianne , Dubreuil Olivier , Carpentier Antoine F. , Tartour Eric , Taieb Julien
Published: March 2023

PDF file - 37K, Patients' characteristics
Supplementary Figure Legend from Quantitative In Vivo Characterization of Intracellular and Extracellular pH Profiles in Heterogeneous Tumors: A Novel Method Enabling Multiparametric pH Analysis
Authors: Lutz Norbert W. , Le Fur Yann , Chiche Johanna , Pouysségur Jacques , Cozzone Patrick J.
Published: March 2023

PDF file - 120K
Supplementary Figure 3 from Quantitative In Vivo Characterization of Intracellular and Extracellular pH Profiles in Heterogeneous Tumors: A Novel Method Enabling Multiparametric pH Analysis
Authors: Lutz Norbert W. , Le Fur Yann , Chiche Johanna , Pouysségur Jacques , Cozzone Patrick J.
Published: March 2023

PDF file - 53K, Scaling corrections.
Supplementary Figure 2 from Quantitative In Vivo Characterization of Intracellular and Extracellular pH Profiles in Heterogeneous Tumors: A Novel Method Enabling Multiparametric pH Analysis
Authors: Lutz Norbert W. , Le Fur Yann , Chiche Johanna , Pouysségur Jacques , Cozzone Patrick J.
Published: March 2023

PDF file - 52K, Conversion of a 31P NMR spectrum of 3-APP into a pHe distribution curve.
Supplementary Figures 1 - 5 from Metformin Decreases Glucose Oxidation and Increases the Dependency of Prostate Cancer Cells on Reductive Glutamine Metabolism
Authors: Fendt Sarah-Maria , Bell Eric L. , Keibler Mark A. , Davidson Shawn M. , Wirth Gregory J. , Fiske Brian , Mayers Jared R. , Schwab Matthias , Bellinger Gary , Csibi Alfredo , Patnaik Akash , Blouin Marie Jose , Cantley Lewis C. , Guarente Leonard , Blenis John , Pollak Michael N. , Olumi Aria F. , Vander Heiden Matthew G. , Stephanopoulos Gregory
Published: March 2023

Figure 1: Oxygen consumption rate of prostate cancer cell lines with different concentrations of metformin. Error bars depict the standard deviation. Standard deviation and p-values are calculated from three biological replicates. Figure 2: Glucose (upper panel) and reductive glutamine (lower panel) contribution to fatty acids in prostate cancer cell lines treated with metformin fitted from the measured incorporation of U-13C labeled glucose or 5-13C labeled glutamine (reductive glutamine contribution (red)) into palmitate. Error bars depict the 95 % confidence interval. Confidence intervals and p-values are calculated from two biological replicates. Figure 3: Comparison of glutamine contribution to tricarboxylic acid cycle in prostate cancer cell lines treated with metformin or rotenone measured by the incorporation of U-13C labeled glutamine into alpha-ketoglutarate (upper panel) and reductive glutamine contribution to palmitate using 5-13C labeled glutamine (lower panel). Confidence intervals and p-values are calculated from two biological replicates. Figure 4: (A) Relative cell count of prostate cancer cell lines treated with a combination of metformin and the glutaminase inhibitor BPTES. Cell counts were normalized to the condition with no metformin and no BPTES added. (B) Relative cell count of Huh7 liver cancer cells, which can grow without glutamine in the presence or absence of metformin. Cell counts were normalized to the corresponding condition with no metformin added. Error bars depict the standard deviation. Standard deviation and p-values are calculated from three biological replicates. Figure 5: (A) TSC2 expression in TSC2 knockdown cells and control. Standard diviation is calculated from three technical replicates. p-values are < 0.005.(B) Metformin sensitivity (2.5mM) in LNCaP cells with and without dimethyl alpha-ketoglutarate given by cell counts normalized to the corresponding condition with no metformin. Standard deviation and p-values are calculated from at least three biological replicates. p-value is < 0.05. All error bars depict the standard deviation.
Supplementary Figure 1 from Avirulent Toxoplasma gondii Generates Therapeutic Antitumor Immunity by Reversing Immunosuppression in the Ovarian Cancer Microenvironment
Authors: Baird Jason R. , Fox Barbara A. , Sanders Kiah L. , Lizotte Patrick H. , Cubillos-Ruiz Juan R. , Scarlett Uciane K. , Rutkowski Melanie R. , Conejo-Garcia Jose R. , Fiering Steven , Bzik David J.
Published: March 2023

PDF file - 135K, Supplementary Figure S1. CD8a+CD11c+DEC205+MHCII+ are the predominant CD45+ MHC II+ APC's in terminal ascites and can be stimulated to efficiently present antigens.
Supplementary Figure Legend from Oncogenic Herpesvirus HHV-8 Promotes Androgen-Independent Prostate Cancer Growth
Authors: Mygatt Justin G. , Singhal Adit , Sukumar Gauthaman , Dalgard Clifton L. , Kaleeba Johnan A.R.
Published: March 2023

PDF file - 73K
Supplementary Figure 5 from Oncogenic Herpesvirus HHV-8 Promotes Androgen-Independent Prostate Cancer Growth
Authors: Mygatt Justin G. , Singhal Adit , Sukumar Gauthaman , Dalgard Clifton L. , Kaleeba Johnan A.R.
Published: March 2023

PDF file - 135K, Predicted outcomes of interactions between HHV-8 and components of the repressive Polycomb repressor complex (PRC2) during latency and upon viral reactivation.
Supplementary Figure 4 from Oncogenic Herpesvirus HHV-8 Promotes Androgen-Independent Prostate Cancer Growth
Authors: Mygatt Justin G. , Singhal Adit , Sukumar Gauthaman , Dalgard Clifton L. , Kaleeba Johnan A.R.
Published: March 2023

PDF file - 118K, Temporal changes in EZH2, SUZ12 and the H3K27-me3 mark during sodium butyrate-induced reactivation of HHV-8.
Supplementary Figure 2 from Oncogenic Herpesvirus HHV-8 Promotes Androgen-Independent Prostate Cancer Growth
Authors: Mygatt Justin G. , Singhal Adit , Sukumar Gauthaman , Dalgard Clifton L. , Kaleeba Johnan A.R.
Published: March 2023

PDF file - 121K, MSMB induces apoptosis in PC3 cells but reverses HHV-8-induced androgen-independent growth in LNCaP-v219 cells.
Supplementary Figure 2 from Autocrine Motility Factor Promotes HER2 Cleavage and Signaling in Breast Cancer Cells
Authors: Kho Dhong Hyo , Nangia-Makker Pratima , Balan Vitaly , Hogan Victor , Tait Larry , Wang Yi , Raz Avraham
Published: March 2023

PDF file - 242K, Supplementary Figure S2. EBNA293 cells do not respond to AMF in p-AKT/p-ERK pathways.
Supplementary Figure 1 from Autocrine Motility Factor Promotes HER2 Cleavage and Signaling in Breast Cancer Cells
Authors: Kho Dhong Hyo , Nangia-Makker Pratima , Balan Vitaly , Hogan Victor , Tait Larry , Wang Yi , Raz Avraham
Published: March 2023

PDF file - 500K, Supplementary Figure S1. gp78/AMFR is not responsible for AMF-induced p-AKT.
Supplementary Figure 7 from An Intact Immune System Is Required for the Anticancer Activities of Histone Deacetylase Inhibitors
Authors: West Alison C. , Mattarollo Stephen R. , Shortt Jake , Cluse Leonie A. , Christiansen Ailsa J. , Smyth Mark J. , Johnstone Ricky W.
Published: March 2023

PDF file - 29K, Supplementary Figure 7. Tumor-bearing WT mice lacking CD4+, CD8+ and/or NK cells or perforin respond successfully to vorinostat treatment.