bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Synthesis and Antimicrobial Activity of Some New Thiazole, Thiophene and Pyrazole Derivatives Containing Benzothiazole Moiety.
Authors: Bondock Samir , Fadaly Walid , Metwally Mohamed A.
Published: December 2010

Starting from benzothiazole derivative (I) a series of new heterocyclic derivatives of type (IV), (VII), (X), (XII), and (XIV) containing the benzothiazole moiety are prepared and their antimicrobial activities are tested.
ChemInform Abstract: Pharmacological Evaluation and Characterizations of Newly Synthesized 1,2,4‐Triazoles.
Authors: Patel Navin B. , Khan Imran H. , Rajani Smita D.
Published: December 2010

A series of 10 1,2,4‐triazoles of type (VI) are evaluated for their antibacterial activity.
ChemInform Abstract: An Efficient One‐Pot Synthesis of Heterocycle‐Fused 1,2,3‐Triazole Derivatives as Anticancer Agents.
Authors: Yan Sheng‐Jiao , Liu Yong‐Jiang , Chen Yu‐Lan , Liu Lin , Lin Jun
Published: December 2010

The title 1,2,3‐triazole derivative (IIIe) exhibits the most powerful in vitro activity against A431 and K562 human tumor cell lines (IC50 < 1.9 μg/ml).
ChemInform Abstract: Synthesis of Novel Sulfanilamide‐Derived 1,2,3‐Triazoles and Their Evaluation for Antibacterial and Antifungal Activities.
Authors: Wang Xian‐Long , Wan Kun , Zhou Cheng‐He
Published: December 2010

Title compounds (VI) are screened in vitro for their antibacterial and antifungal activities.
ChemInform Abstract: Design, Synthesis and Pro‐apoptotic Antitumor Properties of Indole‐Based 3,5‐Disubstituted Oxadiazoles.
Authors: Ziedan Noha I. , Stefanelli Fabio , Fogli Stefano , Westwell Andrew D.
Published: December 2010

A series of new indole‐based 3,5‐disubstituted 1,2,4‐oxadiazoles is designed and synthesized as potential pro‐apoptotic antitumor agents.
ChemInform Abstract: Synthesis and Anticancer Activity of 5‐(3‐Indolyl)‐1,3,4‐thiadiazoles.
Authors: Kumar Dalip , Kumar N. Maruthi , Chang Kuei‐Hua , Shah Kavita
Published: December 2010

A facile synthesis of diverse 5‐(3‐indolyl)‐1,3,4‐thiadiazoles (II) is reported.
ChemInform Abstract: InCl3 Mediated One‐Pot Multicomponent Synthesis, Antimicrobial, Antioxidant and Anticancer Evaluation of 3‐Pyranyl Indole Derivatives.
Authors: Lakshmi Neelakandan Vidhya , Thirumurugan Prakasam , Noorulla K. M. , Perumal Paramasivan T.
Published: December 2010

17 3‐Pyranyl indole derivatives of type (IV) are prepared by InCl3‐mediated one‐pot three‐component synthesis (tandem Knoevenagel—Michael reaction).
ChemInform Abstract: Copper‐Catalyzed Asymmetric 1,4‐Hydroboration of Coumarins with Pinacolborane: Asymmetric Synthesis of Dihydrocoumarins.
Authors: Kim Hyohyun , Yun Jaesook
Published: December 2010

The addition of pinacolborane to 4‐substituted coumarins in the presence of an optically active copper catalyst affords boron enolates which by reaction with electrophiles give the target dihydrocoumarins.
ChemInform Abstract: A Different Route to 3‐Aryl‐4‐hydroxycoumarins.
Authors: Rodriguez Sergio A. , Baumgartner Maria T.
Published: December 2010

Photoinduced direct arylation of 4‐hydroxycoumarin with halides results in formation of title compounds (III).
ChemInform Abstract: Copper‐Catalyzed Olefin Aminoacetoxylation.
Authors: Mancheno Danny E. , Thornton Aaron R. , Stoll Armin H. , Kong Aidi , Blakey Simon B.
Published: December 2010

Terminal olefin substrates are cyclized with PhI(OAc)2 as an oxidant with the formation of 3‐acetoxypiperidine predominantly [cf.
ChemInform Abstract: Carbonic Anhydrase Inhibitors. Regioselective Synthesis of Novel 1‐Substituted 1,4‐Dihydro‐4‐oxo‐3‐pyridinesulfonamides and Their Inhibition of the Human Cytosolic Isozymes I and II and Transmembrane Cancer‐Associated Isozymes IX and XII.
Authors: Brzozowski Zdzislaw , Slawinski Jaroslaw , Innocenti Alessio , Supuran Claudiu T.
Published: December 2010

A series of novel 1‐substituted 1,4‐dihydro‐4‐oxo‐3‐pyridinesulfonamides of type (III), (V) and (VII) is prepared and their inhibition of the human cytosolic isozymes I and II and transmembrane cancer‐associated isozymes II and XII is tested.
ChemInform Abstract: Synthesis and Pharmacological Evaluation of Condensed Heterocyclic 6‐Substituted 1,2,4‐Triazolo‐[3,4‐b]‐1,3,4‐thiadiazole and 1,3,4‐Oxadiazole Derivatives of Isoniazid.
Authors: Gilani Sadaf J. , Khan Suroor A. , Siddiqui Nadeem
Published: December 2010

All synthesized substances are evaluated for their anti‐inflammatory, analgesic, ulcerogenic, and lipid peroxidation activities.
ChemInform Abstract: Design, Synthesis and Antimicrobial Activities of Some New Quinoline Derivatives Carrying 1,2,3‐Triazole Moiety.
Authors: Thomas K. D. , Adhikari Airody Vasudeva , Shetty N. Suchetha
Published: December 2010

25 title compounds of type (IX) are prepared and tested for their antibacterial and antifungal activities.
ChemInform Abstract: An Expedient Synthesis of Indolo[1,2‐a]quinolines via Mn(OAc)3‐Mediated Oxidative Free Radical Cyclization and NaI/O2‐Assisted Dealkoxycarbonylation/Aerobic Oxidation Cascade.
Authors: Lee Hyun Seung , Kim Se Hee , Kim Yu Mi , Kim Jae Nyoung
Published: December 2010

Two different approaches are developed for the preparation of the biologically important target heterocycles.
ChemInform Abstract: Synthesis of Methyl‐Substituted 1,7‐Phenanthroline Derivatives by Condensation of 2‐Methylquinolin‐5‐amine with Aromatic Aldehydes and Cyclic 1,3‐Diketones.
Authors: Kozlov N. G. , Gusak K. N.
Published: December 2010

A convenient three‐component one‐pot procedure for the synthesis of difficultly accessible methyl‐substituted 1,7‐phenanthroline derivatives (IV) (16 examples) is developed.
ChemInform Abstract: Remarkable Facilitation of Hetero‐Cycloisomerizations with Water and Other Polar Protic Solvents: Metal‐Free Synthesis of Indolizines.
Authors: Narayan Alison R. Hardin , Sarpong Richmond
Published: December 2010

Indolizines are obtained in hetero‐cycloisomerization reactions of propargylic alcohol derivatives in the presence of pure water, without the use of any metal catalyst, additive, and toxic organic solvent.
ChemInform Abstract: Regioselective Synthesis and Molecular Modeling Study of Vasorelaxant Active 7,9‐Dioxa‐1,2‐diaza‐spiro[4.5]dec‐2‐ene‐6,10‐diones.
Authors: Girgis Adel S. , Ismail Nasser S. M. , Farag Hanaa , El‐Eraky Wafaa I. , Saleh Dalia O. , Tala Srinivasa R. , Katritzky Alan R.
Published: December 2010

Regioselective 1,3‐dipolar cycloaddition of nitrilimines, generated in situ from hydrazonoyl chloride (II) to (I) yields 12 spiro compounds of type (III).
ChemInform Abstract: Synthesis and Biological Screening of 7‐Alkyl‐3,3a,4,5‐tetrahydroisoxazolo[3,4‐d]pyridazines and 3‐Chloromethyl‐7‐methyl‐3a,4‐dihydro‐3H‐isoxazolo[3,4‐d][1,2]oxazine.
Authors: Naqvi Tahira , Kapoor Kamal K. , Sharma Rattan Lal
Published: December 2010

Novel heterocycles are synthesized and screened for their antibacterial and antifungal activity.
ChemInform Abstract: One‐Pot Synthesis of Substituted Pyrimidine Derivatives from Acetylenedicarboxylate, Amine and Orthoformate.
Authors: Nagarajan Arasampattu S. , Reddy Boreddy S. R.
Published: December 2010

The simple procedure allows an efficient synthesis of the pharmaceutically important heterocyclic skeleton (16 examples).
ChemInform Abstract: Asymmetric Organocatalytic Tandem Reaction to Chiral Pyrimidinone Derivatives Using Urea as Dinitrogen Source.
Authors: He Zhao‐Quan , Zhou Quan , Wu Li , Chen Ying‐Chun
Published: December 2010

The optically active pyrimidones are prepared via an aza‐Michael addition—hemiaminal formation—dehydroxylation reaction using a chiral prolinol O‐Tms ether as catalyst.
ChemInform Abstract: Synthesis and Suzuki—Miyaura Reactions of 5‐Halo‐3,4‐dihydropyrimidin‐2(1H)‐ones.
Authors: Zych Andrew J. , Wang Hong‐Jun , Sakwa Samuel A.
Published: December 2010

Halo derivatives of type (VI) and (XI) are prepared via the corresponding carboxylic acids following a treatment with NaI or NaBr under conditions A).
ChemInform Abstract: Synthesis of Novel Thiazolo[5,4‐d]pyrimidines.
Authors: Chattopadhyay Gautam , Saha Debnath , Ray Partha Sinha , Naskar Subhendu , Sarkar Swarbhanu
Published: December 2010

The approx.
ChemInform Abstract: Thiophenol‐Mediated Radical Cyclization: An Expedient Approach to 2H‐Pyrrolo[3,2‐d]pyrimidines (9‐Deazaxanthine Analogues).
Authors: Majumdar K. C. , Mondal Shovan , Ghosh Debankan
Published: December 2010

Treatment of diones (I) and mixed ‐Me/‐Et analogues affords the target compounds (III)(6 examples) in moderate yields.
ChemInform Abstract: Diastereo‐ and Enantioselective Gold(I)‐Catalyzed Intermolecular Tandem Cyclization/[3 + 3]Cycloadditions of 2‐(1‐Alkynyl)‐2‐alken‐1‐ones with Nitrones.
Authors: Liu Feng , Qian Deyun , Li Lei , Zhao Xiaoli , Zhang Junliang
Published: December 2010

Optically active heterobicyclic furo[3,4‐d][1,2]oxazines are obtained by the present new asymmetric gold(I)‐catalyzed cycloaddition of 2‐(1‐alkynyl)‐2‐alken‐1‐ones with nitrones.
ChemInform Abstract: Syntheses on the Basis of Diethyl (2‐Morpholinoethyl)malonate.
Authors: Mesropyan E. G. , Galstyan A. S. , Avetisyan A. A. , Ambartsumyan G. B.
Published: December 2010

New functionally substituted butan‐4‐olides and 5‐[2‐(morpholino)ethyl]barbituric and ‐thiobarbituric acids are synthesized starting from diester (III).
ChemInform Abstract: Synthesis and Antioxidant Activity of Quinolinobenzothiazinones.
Authors: Kumar M. , Sharma Kshitija , Samarth R. M. , Kumar A.
Published: December 2010

Title compounds (III) are evaluated for their antioxidant activity by radical scavenging (DPPH) and ABTS radical cation decolorization assays.
ChemInform Abstract: A Novel Series of [3.2.1] Azabicyclic Biaryl Ethers as α3β4 and α6/4β4 Nicotinic Receptor Agonists.
Authors: Lowe John A. III , et al. et al.
Published: December 2010

Key steps in the presented strategy are a diastereoselective Mitsunobu reaction to (III) followed by Suzuki coupling to (V).
ChemInform Abstract: Expeditious Synthesis of Imidazole‐ and Pyrrole‐Fused Benzodiazocines.
Authors: Mishra Amita , Batra Sanjay
Published: December 2010

The synthesis of benzodiazocines (VI) involves Horner—Wadsworth—Emmons olefination of an N‐(o‐nitrophenyl)imidazolecarbaldehyde or the pyrrole analogue (I) followed by reduction of nitro group and olefin double bond and cyclization reaction.
ChemInform Abstract: Diversity‐Oriented Microwave‐Assisted Synthesis of the 3‐Benzazepine Framework.
Authors: Peshkov Vsevolod A. , Pereshivko Olga P. , Donets Pavel A. , Mehta Vaibhav P. , Van der Eycken Erik V.
Published: December 2010

Title synthesis involves a microwave‐assisted three‐component reaction of an amine with an aldehyde and a terminal alkyne or two equivalents of alkyne, followed by Pd‐catalyzed microwave‐assisted cyclization.
ChemInform Abstract: Preparation of Azepinones.
Authors: Dubinina Galyna G. , Yoshida Wesley Y. , Chain William J.
Published: December 2010

The Diels—Alder Reaction of aziridine (I) with dienes (II) affords bicyclo[4.1.0]azaheptenes of type (III).
ChemInform Abstract: Synthesis and Antibacterial Activity of Some Novel 6‐(1H‐Benz [d]imidazol‐2‐yl)‐8‐(5‐nitro‐2‐furyl)‐3‐(4‐pyridyl)‐7,8‐dihydro [1,2,4]triazolo[3,4‐b][1,3,4]thiadiazepines.
Authors: Reddy Vanga Malla , Reddy Kunduru Ravinder
Published: December 2010

The title compounds (VIII) exhibit weak antimicrobial and antifungal activity.
ChemInform Abstract: Cyclopalladated Ferrocenylimine as Efficient Catalyst for the Syntheses of Arylboronate Esters.
Authors: Wang Lianhui , Li Jingya , Cui Xiuling , Wu Yusheng , Zhu Zhiwu , Wu Yangjie
Published: December 2010

Both aryl/heteroaryl bromides and chlorides undergo the coupling reaction with diboron compound (III) in the presence of PCy3 catalyst (Ia) and biphenylphosphino catalyst (Ib), respectively, under optimized conditions.
ChemInform Abstract: Directed ortho Borylation of Phenol Derivatives Catalyzed by a Silica‐Supported Iridium Complex.
Authors: Yamazaki Kenji , Kawamorita Soichiro , Ohmiya Hirohisa , Sawamura Masaya
Published: December 2010

The choice of the carbamoyl protecting group is crucial.
ChemInform Abstract: Efficient Method to Prepare Diethylphosphonacetamides.
Authors: Scaravelli Federico , Bacchi Sergio , Massari Luca , Curcuruto Ornella , Westerduin Pieter , Maton William
Published: December 2010

Acid (I) reacts with various amines and N‐heterocycles such as the oxazolidinone (IV) in the presence of T3P as coupling reagent.
ChemInform Abstract: Silica Gel and Polystyrene Supported Aluminum Chloride as Heterogeneous Catalysts for the Preparation of α‐Aminophosphonates.
Authors: Boroujeni Kaveh Parvanak , Shirazi Amir Nasrolahi
Published: December 2010

Aluminum chloride supported on silica gel or cross‐linked polystyrene is an environmentally‐friendly heterogeneous catalyst for the synthesis of α‐aminophosphonates via three‐component condensation of carbonyl compounds with amines and diethyl phosphite.
ChemInform Abstract: New Cyclization of 4‐Oxahepta‐1,6‐diynes Bearing Sulfur and Selenium Functional Groups.
Authors: Yoshimatsu Mitsuhiro , Watanabe Hiroyasu , Koketsu Eri
Published: December 2010

A variety of 1‐sulfanyl and 1‐selanyl derivatives are reacted with sodium alkoxides or thiolates to afford the corresponding trisubstituted furan derivatives with high yields [cf.
ChemInform Abstract: Two New Sesquiterpenes from the Fungus Stereum sp.
Authors: Liu Fang‐Fang , Li Guo‐Hong , Yang Zhong‐Shan , Zheng Xi , Yang Yue , Zhang Ke‐Qin
Published: December 2010

The isolation and structure elucidation of two novel sesquiterpenes, stereumin F (I) and G (II), are reported.
ChemInform Abstract: Enantioselective Rearrangement of Proline Sulfonamides: An Easy Entry to Enantiomerically Pure α‐Aryl Quaternary Prolines.
Authors: Foschi Francesca , Landini Dario , Lupi Vittoria , Mihali Voichita , Penso Michele , Pilati Tullio , Tagliabue Aaron
Published: December 2010

A highly enantioselective rearrangement of proline‐derived sulfonamides proceeds in the presence of base to give α‐arylprolines with a quaternary stereocenter in up to 96% optical purity.
ChemInform Abstract: Total Synthesis and Biological Evaluation of Tambjamine K and a Library of Unnatural Analogues.
Authors: Aldrich Leslie N. , Stoops Sydney L. , Crews Brenda C. , Marnett Lawrence J. , Lindsley Craig W.
Published: December 2010

Tambjamine K (VII a) exhibits antiproliferative and cytotoxic effects against different tumor and non‐tumor cell lines.
ChemInform Abstract: Concise Synthesis of Cannabisin G.
Authors: Li Dawei , Li Wenling , Wang Qian , Yang Zhaoqi , Hou Zijie
Published: December 2010

A four‐step synthesis of cannabisin G (VI) is presented.
ChemInform Abstract: Synthesis of the C‐1 to C‐18 Fragment of Pamamycins 607 and 621A.
Authors: Ren Guobao , Wu Yikang
Published: December 2010

The cross metathesis reaction between substrates (I) and (II) representing segments C‐1 to C‐4 and C‐5 to C‐18, resp., as a considered strategy for the synthesis of the title C‐1 to C‐18 fragment fails.
ChemInform Abstract: Regioselective Hydrostannation of Diarylalkynes Directed by a Labile ortho Bromine Atom: An Easy Access to Stereodefined Triarylolefins, Hybrids of Combretastatin A‐4 and Isocombretastatin A‐4.
Authors: Rasolofonjatovo Evelia , Provot Olivier , Hamze Abdallah , Bignon Jerome , Thoret Sylviane , Brion Jean‐Daniel , Alami Mouad
Published: December 2010

A series of 7 triarylolefins of type (VII) or (VIII) bearing the combretastatin A‐4 and isocombretastatin A‐4 core are prepared.
ChemInform Abstract: Stereoselective Synthesis and Biological Evaluation of (R)‐Rugulactone, (6R)‐((4R)‐Hydroxy‐6‐phenyl‐hex‐2‐enyl)‐5,6‐dihydro‐pyran‐2‐one and Its 4S Epimer.
Authors: Reddy K. Kumar , Shekhar V. , Prabhakar P. , Babu B. Chinna , Siddhardha B. , Murthy U. S. N. , Venkateswarlu Y.
Published: December 2010

Employing proline‐catalyzed α‐aminooxylation and inversion by Mitsunobu reaction as key chirality‐inducing steps, title compounds (VIII), (R)‐rugulactone (IX), and (X) are prepared.
ChemInform Abstract: A Total Synthesis of Natural Rhizobialide.
Authors: Guan Jing , Zou Yang , Gao Po , Wu Yikang , Yue Zhengyu
Published: December 2010

Starting from (S)‐glutamic acid as source of the stereogenic center, the natural butanolide rhizobialide (I) is synthesized in enantiopure form for the first time confirming the absolute configuration of (I).
ChemInform Abstract: Synthesis of Talosin A and B, Two Bioactive Isoflavonoid Glycosides.
Authors: Wu Zhongtao , Lian Gaoyan , Yu Biao , Wang Zhenzhong , Zhao Yiwu , Xiao Wei
Published: December 2010

Talosin A (Ia) and B (Ib), two genistein 6‐deoxy‐α‐L‐talopyranosides with excellent antifungal and anti‐inflammatory activities, are synthesized for the first time.
ChemInform Abstract: A Highly Efficient and Selective Turn‐on Fluorescent Sensor for Cu2+ Ion.
Authors: Wang Xuehua , Cao Jing , Chen Chuanfeng
Published: December 2010

A new fluorescent chemosensor (I) based on an open‐chain azacrown bearing a quinoline moiety is synthesized in a four‐step procedure starting from 2‐nitrophenol.
ChemInform Abstract: Synthesis and Antifungal Evaluation of Novel Triazole Derivatives as Inhibitors of Cytochrome P450 14α‐Demethylase.
Authors: Yu Shichong , Chai Xiaoyun , Hu Honggang , Yan Yongzheng , Guan Zhongjun , Zou Yan , Sun Qingyan , Wu Qiuye
Published: December 2010

Novel fluconazole analogues (I) are obtained via click reaction approach at which the 1,4‐disubstituted regioisomers are formed exclusively in the final step.
ChemInform Abstract: Electronic and Magnetic Structure of Graphene Nanoribbons
Authors: Palacios J. J. , Fernandez‐Rossier J. , Brey L. , Fertig H. A.
Published: December 2010

Review: 24 refs.
ChemInform Abstract: “Soft” Chemical Synthesis and Manipulation of Semiconductor Nanocrystals
Authors: Hollingsworth Jennifer A. , Klimov Victor I.
Published: December 2010

Review: 147 refs.
ChemInform Abstract: Importance of Kinetic Models in the Analysis of Steelmaking Reactions
Authors: Kitamura S.
Published: December 2010

Review: 12 refs.
ChemInform Abstract: Fuel Cell Engineering: Toward the Design of Efficient Electrochemical Power Plants
Authors: Sundmacher Kai
Published: December 2010

Review: 375 refs.
ChemInform Abstract: Solution and Solid‐State Methods to Prepare Au Nanoparticles: A Comparison
Authors: Diaz Carlos , Valenzuela Maria Luisa
Published: December 2010

Review: 47 refs.
ChemInform Abstract: Magnetic Nanowires by Electrodeposition within Templates
Authors: Schloerb Heike , Haehnel Veronika , Khatri Manvendra Singh , Srivastav Ajeet , Kumar Amit , Schultz Ludwig , Faehler Sebastian
Published: December 2010

Review: 62 refs.
ChemInform Abstract: MOFs, MILs and More: Concepts, Properties and Applications for Porous Coordination Networks (PCNs)
Authors: Janiak Christoph , Vieth Jana K.
Published: December 2010

Review: 235 refs.
ChemInform Abstract: Coordination and Dehydrogenation of Amine—Boranes at Metal Centers
Authors: Alcaraz Gilles , Sabo‐Etienne Sylviane
Published: December 2010

Review: ca. 80 refs.
ChemInform Abstract: U(VI) Oxygen Polyhedra as Pillars for Building Frameworks from Uranophane‐Type Layers
Authors: Jouffret Laurent , Rivenet Murielle , Abraham Francis
Published: December 2010

Review: 24 refs.
ChemInform Abstract: C—O Reductive Elimination from High Valent Pt and Pd Centers
Authors: Vedernikov Andrei N.
Published: December 2010

Review: 38 refs.
ChemInform Abstract: State‐of‐the‐Art Catalysts for Hydrogenation of Carbon Dioxide
Authors: Federsel Christopher , Jackstell Ralf , Beller Matthias
Published: December 2010

Review: 57 refs.
ChemInform Abstract: “Try and Fall Sick ...” — The Composer, Chemist, and Surgeon Aleksandr Borodin.
Authors: Podlech Joachim
Published: December 2010

Review: 53 refs.
ChemInform Abstract: Nanostructured Carbonaceous Material from Molecular Precursors.
Authors: Hoheisel Tobias N. , Schrettl Stephen , Szilluweit Ruth , Frauenrath Holger
Published: December 2010

Review: 236 refs.
ChemInform Abstract: Chemistry and Biology of the Caged Garcinia Xanthones
Authors: Chantarasriwong Oraphin , Batova Ayse , Chavasiri Warinthorn , Theodorakis Emmanuel A.
Published: December 2010

Review: more than 200 refs.
ChemInform Abstract: Treasures from the Sea: Discovery and Total Synthesis of Ammosamides
Authors: Zurwerra Didier , Wullschleger Christoph W. , Altmann Karl‐Heinz
Published: December 2010

Review: 10 refs.
ChemInform Abstract: The Measure of All Rings — N‐Heterocyclic Carbenes
Authors: Droege Thomas , Glorius Frank
Published: December 2010

Review: ca. 100 refs.
ChemInform Abstract: Structural Diversity of Multi‐Component Self‐Assembled Systems Incorporating p‐Sulfonatocalix[4]arene.
Authors: Ling Irene , Alias Yatimah , Raston Colin L.
Published: December 2010

Review: 56 refs.
ChemInform Abstract: Ionic Mixed Interactions in Macromolecules
Authors: Ciferri Alberto
Published: December 2010

Review: 114 refs.
ChemInform Abstract: Complexity‐Building Annulations of Strained Cycloalkanes and C=O π Bonds.
Authors: Campbell Matthew J. , Johnson Jeffrey S. , Parsons Andrew T. , Pohlhaus Patrick D. , Sanders Shanina D.
Published: December 2010

Review: formation of furan and pyran structures; 80 refs.
ChemInform Abstract: Cobalt‐Catalyzed Asymmetric Hydrovinylation
Authors: Vogt Dieter
Published: December 2010

Review: 15 refs.
ChemInform Abstract: Homocoupling Reactions of Alkynes, Alkenes and Alkyl Compounds
Authors: Stefani Helio A. , Guarezemini Alexandre S. , Cella Rodrigo
Published: December 2010

Review: ca. 180 refs.
ChemInform Abstract: Anion Recognition by Hydrogen Bonding: Urea‐Based Receptors
Authors: Amendola Valeria , Fabbrizzi Luigi , Mosca Lorenzo
Published: December 2010

Review: ca. 100 refs.
ChemInform Abstract: Cryptand‐Like Anion Receptors
Authors: Kang Sung Ok , Llinares Jose M. , Day Victor W. , Bowman‐James Kristin
Published: December 2010

Review: 136 refs.
ChemInform Abstract: Appraisal of Heterogeneous Solid Acid—Base Catalysts for Transesterification
Authors: Jothiramalingam R. , Viswanathan B. , Wang M. K.
Published: December 2010

Review: 74 refs.
ChemInform Abstract: Recent Advances in the Synthesis of Functionalized Carbohydrate Azides
Authors: Witczak Zbigniew J.
Published: December 2010

Review: 63 refs.
ChemInform Abstract: Solution‐ and Solid‐Phase Synthesis of Oligosaccharides
Authors: Eller Steffen , Weishaupt Markus , Seeberger Peter H.
Published: December 2010

Review: 106 refs.
ChemInform Abstract: Synthetic Approaches to 1,2‐Heteraphosphacyclanes
Authors: Odinets Irina L. , Aladzheva Inga M.
Published: December 2010

Review: 208 refs.
ChemInform Abstract: Cn‐Symmetric Calixarenes and Resorcinarenes
Authors: McIldowie M. J. , Mocerino M. , Ogden M. I.
Published: December 2010

Review: 90 refs.
ChemInform Abstract: Transmetalation Reactions Producing Organocopper Compounds
Authors: Rosenker Christopher J. , Wipf Peter
Published: December 2010

Review: 263 refs.
ChemInform Abstract: Progress in the Chemistry of Condensed Thiazolopyrimidines
Authors: Metwally M. A. , Abdel‐Wahab Bakr F.
Published: December 2010

Review: 130 refs.
ChemInform Abstract: Pyridazinoindoles: Synthesis and Properties
Authors: Samsoniya Sh. A. , Chikvaidze I. Sh. , Ozdesh M.
Published: December 2010

Review: 64 refs.
ChemInform Abstract: Graphene Field‐Effect Transistors: Electrochemical Gating, Interfacial Capacitance, and Biosensing Applications
Authors: Chen Fang , Qing Quan , Xia Jilin , Tao Nongjian
Published: December 2010

Review: 70 refs.
ChemInform Abstract: BioMOFs: Metal—Organic Frameworks for Biological and Medical Applications
Authors: McKinlay Alistair C. , Morris Russell E. , Horcajada Patricia , Ferey Gerard , Gref Ruxandra , Couvreur Patrick , Serre Christian
Published: December 2010

Review: 41 refs.
ChemInform Abstract: A Multi‐Faceted Approach to Elucidate the Crystal Structure of D‐Ribose: Similarities to Protein Structure Determination.
Authors: Saenger Wolfram
Published: December 2010

Review: 12 refs.
ChemInform Abstract: Selenium‐ and Tellurium‐Containing Multifunctional Redox Agents as Biochemical Redox Modulators with Selective Cytotoxicity
Authors: Jamier Vincent , Ba Lalla A. , Jacob Claus
Published: December 2010

Review: 37 refs.
ChemInform Abstract: Small Molecules that Modulate Quorum Sensing and Control Virulence in Pseudomonas aeruginosa.
Authors: Mattmann Margrith E. , Blackwell Helen E.
Published: December 2010

Review: 98 refs.
ChemInform Abstract: Tellurium: An Element with Great Biological Potency and Potential
Authors: Ba Lalla Aicha , Doering Mandy , Jamier Vincent , Jacob Claus
Published: December 2010

Review: 91 refs.
ChemInform Abstract: Exploiting Cavities in Supramolecular Gels
Authors: Foster Jonathan A. , Steed Jonathan W.
Published: December 2010

Review: 66 refs.
ChemInform Abstract: Polymeric Multilayer Capsules in Drug Delivery
Authors: De Cock Liesbeth J. , De Koker Stefaan , De Geest Bruno G. , Grooten Johan , Vervaet Chris , Remon Jean Paul , Sukhorukov Gleb B. , Antipina Maria N.
Published: December 2010

Review: 219 refs.
ChemInform Abstract: Enhancement of Insulin Absorption Through Mucosal Membranes Using Cationic Polymers
Authors: Seki Toshinobu
Published: December 2010

Review: 11 refs.
ChemInform Abstract: Molecular Balances for Quantifying Non‐Covalent Interactions
Authors: Mati Ioulia K. , Cockroft Scott L.
Published: December 2010

Review: 67 refs.
ChemInform Abstract: The Design of Fluorescent Ratiometric Nanosensors
Authors: Doussineau Tristan , Schulz Anja , Lapresta‐Fernandez Alejandro , Moro Artur , Koersten Susanne , Trupp Sabine , Mohr Gerhard J.
Published: December 2010

Review: 50 refs.
e‐WOM scale : Une échelle de mesure du bouche‐à‐oreille dans un contexte de services électroniques
Authors: Goyette Isabelle , Ricard Line , Bergeron Jasmin , Marticotte François
Published: December 2010

Drawing data from a survey of 218 consumers across two samples, we developed a measurement scale of the word‐of‐mouth construct (e‐WOM scale) in the context of electronic service. A battery of statistical tests indicated that the WOM construct encompasses four dimensions: WOM intensity, WOM positive behaviours, WOM negative behaviours, and WOM content. Our contribution lies in offering a WOM scale that can be used as a strategic tool for business managers aiming to improve their word‐of‐mouth marketing strategies. Copyright © 2010 ASAC. Published by John Wiley & Sons, Ltd.
Myocardial Performance Index Suggests Optimal Fluid Loss During Hemodialysis
Authors: Papadopoulou Elektra S. , Toumanidis Savvas T. , Tsirpanlis George , Trika Chrisanthi O. , Kalatzopoulou Garyfalia , Moulopoulos Spyridon D.
Published: December 2010

Background

Patients on long‐term maintenance hemodialysis (HD) are at high risk of developing cardiovascular disease and suffering various cardiovascular complications during HD.

Hypothesis

The purpose of this study was to evaluate the influence of changing loading conditions on the myocardial performance index (MPI) in patients on long‐term HD and to specify an optimal level of fluid loss during HD that would maintain stable global cardiac function.

Methods

The study consisted of 52 patients with end‐stage renal failure (ESRF), mean age 56±11.7 y, range: 25–80 y, on regular HD. For each patient a complete echocardiographic‐Doppler examination was performed before and after HD. Systolic and diastolic parameters of left ventricular function were measured, and the myocardial performance index (MPI) was calculated.

Results

The MPI was significantly prolonged after HD (0.47±0.15 before HD versus 0.59±0.16 after HD, p < 0.001). Mean change in body weight during HD was 2.1±0.86 kg. The MPI did not change significantly in patients with intradialytic weight loss up to 1.75 kg.

Conclusions

The MPI value seems to be independent of acute preload changes only when fluid loss is less than 1.75 kg. A 1.75‐kg fluid loss during HD seems to be the optimal goal. In ESRF patients on HD, the MPI seems to be a good indicator of global left ventricular function and potentially a valuable aid in the effort to maintain optimal fluid balance.

The authors have no funding, financial relationships, or conflicts of interest to disclose.
Effects of the Aging Process on Left Ventricular Systolic and Diastolic Synchronicity Indexes: Insights From 160 “Completely” Healthy Volunteers
Authors: Kim Hyung‐Kwan , Sohn Dae‐Won , Chang Sung‐A , Park Keun‐Ho , Park Jin‐Shik , Kim Yong‐Jin , Oh Byung‐Hee , Park Young‐Bae
Published: December 2010

Background

Growing attempt to use left ventricular (LV) systolic (LVSIsys) and diastolic (LVSIdia) synchronicity indexes in the process of selecting potential responders to cardiac resynchronization therapy has created a need for normative reference values.

Hypothesis

This study sought: (1) to determine normal reference ranges for LVSIsys and LVSIdia, and (2) to assess their relationships to age and conventional parameters reflecting LV systolic and diastolic functions.

Methods

We recruited 160 healthy volunteers (104 men) free of any systemic or cardiovascular disease. Maximal difference and standard deviation of time to peak systolic and peak early diastolic myocardial velocities for LVSIsys and LVSIdia were measured using 6 and 12 segment models.

Results

Normal ranges for LVSIsys and LVSIdia obtained in this study were slightly higher than previously reported. The normal aging process did not significantly change LVSIsys, whereas LVSIdia progressively and consistently increased with age. Significant correlations were observed between LVSIdia and parameters representing LV diastolic function, that is, early mitral inflow velocity and its deceleration time, and early mitral annulus velocity. A physiologic increase in LV mass/Ht2.7 showed a weak, but significant correlation with LVSIdia (r = 0.15–0.22), but not with LVSIsys. On multivariate analysis, an age‐dependent increase in LVSIdia was confirmed.

Conclusions

In this study, we propose age‐specific reference ranges for LVSIsys and LVSIdia. LVSIsys remains stable throughout age groups, whereas LVSIdia progressively increases with age. We believe that the reference values provided here will be useful for defining abnormal LV synchronous contraction and relaxation. Copyright © 2010 Wiley Periodicals, Inc.

This work was presented in part at the Annual Scientific Session of the American Society of Echocardiography, Seattle, Washington, June 16–20, 2007.
Conversion of Infarction‐Associated Atrial Fibrillation by Restoration of Atrial Perfusion
Authors: Blanton Robert M. , Nappi Anthony , Kimmelstiel Carey D.
Published: December 2010

We report a patient who presented with new onset atrial fibrillation in the setting of inferior ST‐segment elevation myocardial infarction (STEMI). Cardiac catheterization revealed proximal occlusion of the left circumflex artery. Balloon angioplasty and stenting restored flow to a large left atrial branch, with prompt conversion of the rhythm to atrial flutter, and then to sinus rhythm. To our knowledge this represents the first demonstration of restoration of sinus rhythm by reversing left atrial ischemia in the setting of STEMI.
Prevalence of Coronary Artery Anomalies in 12,457 Adult Patients Who Underwent Coronary Angiography
Authors: Yildiz Ahmet , Okcun Baris , Peker Tezcan , Arslan Caner , Olcay Ayhan , Bulent Vatan M.
Published: December 2010

Background

Coronary artery anomalies are found in 0.2% to 1.3% of patients undergoing coronary angiography and 0.3% of an autopsy series. We aimed to estimate the frequency of coronary artery anomalies in our patient population.

Methods

The data were collected retrospectively by analyzing the angiographic data of 12 457 consecutive adult patients undergoing coronary angiography between September 2002 and October 2007.

Results

Coronary artery anomalies were found in 112 patients (0.9% incidence), 100 patients (89.3%) had origin and distribution anomalies, and 12 patients (10.7%) had coronary artery fistulae. Their mean age was 52 ± 8 years (range, 22–79 y). Separate origins of left anterior descending and left circumflex coronary artery from the left sinus of Valsalva was the most common anomaly (63.4%). The right coronary artery rising from the left coronary sinus of Valsalva was found in 10 (8.9%) patients. Anomalous origin of the left circumflex coronary artery from the right sinus of Valsalva was seen in 10 (8.9%) patients. The left main coronary artery from the right coronary sinus of Valsalva was found in 1 (0.89%) patient while an isolated single coronary artery was seen in 2 (1.78%) patients.

Conclusion

The incidence and the pattern of coronary artery anomalies in our patient population were almost identical with previous studies. Cardiologists should be aware of the coronary anomalies which may be associated with potentially serious cardiac events, because recognition of these coronary anomalies is mandatory in order to prescribe appropriate therapy.
Family Coronary Heart Disease: A Call to Action
Authors: Superko H. Robert , Roberts Robert , Garrett Brenda , Pendyala Lakshmana , King III Spencer
Published: December 2010

A family history of coronary heart disease (CHD) is an accepted risk factor for cardiovascular events and is independent of common CHD risk factors. Advances in the understanding of genetic influences on CHD risk provide the opportunity to apply this knowledge and improve patient care. Utility of inherited cardiovascular risk testing exists by utilizing both phenotypes and genotypes and includes improved CHD risk prediction, selection of the most appropriate treatment, prediction of outcome, and family counseling. The major impediment to widespread clinical adoption of this concept involves un‐reimbursed staff time, educational needs, access to a standardized and efficient assessment mechanism, and privacy issues. The link between CHD and inheritance is indisputable and the evidence strong and consistent. For clinicians, the question is how to utilize this information, in an efficient manner, in order to improve patient care and detection of high‐risk family members. Copyright © 2010 Wiley Periodicals, Inc.

Robert Superko has no conflicts. Lakshmana Pendyala has no conflicts. Brenda Garrett is a consultant for CardioDx. Spencer King has no conflicts.

Supported in part by FEMA grant No. 2006‐FP‐01744 and the Cholesterol, Genetics and Heart Disease Institute.
Diastolic Heart Failure Versus Diastolic Dysfunction: Difference in Renal Function
Authors: Victor Brett M. , Barron John T.
Published: December 2010

Background

Despite the common finding of diastolic dysfunction with a preserved ejection fraction on routine echocardiography in elderly patients, it is unknown why some patients with isolated diastolic dysfunction are asymptomatic whereas others develop diastolic heart failure (ie, signs and symptoms of congestive heart failure).

Hypothesis

We hypothesized that renal insufficiency is more common in those patients with diastolic heart failure than those with diastolic dysfunction; it is intrinsic renal insufficiency that determines whether diastolic dysfunction becomes symptomatic.

Methods

We reviewed 686 consecutive transthoracic echocardiograms (TTEs). Patient age, race, weight, and cardiovascular risk factors (hypertension, diabetes, and coronary artery disease) were recorded. We used the Framingham Criteria for Congestive Heart Failure to determine the presence of diastolic heart failure by symptoms, exam findings, and radiological studies. Average creatinine clearance (CrCl), calculated by both total body weight and lean body mass, and estimated glomerular filtration rate (eGFR) were calculated for each group.

Results

Of the 686 TTEs reviewed, 18 patients fulfilled the criteria for diastolic heart failure and 118 patients had asymptomatic diastolic dysfunction. There was no difference in age, race, or gender nor was there any difference in the echocardiographic variables of diastolic function or left ventricular hypertrophy between groups. Multiple regression analysis showed only lower CrCl (44 ± 36 mL/min vs 76 ± 42 mL/min, total body weight, P = 0.0015; and 31 ± 24 mL/min vs 51 ± 27 mL/min, lean body mass, P = 0.0012) and eGFR (44 ± 33 mL/min/M2 vs 69 ± 28 mL/min/M2, P = 0.0003) were associated with diastolic heart failure. There was no significant difference in the presence of hypertension, diabetes, and coronary artery disease between groups.

Conclusions

The results of this study support the hypothesis that patients with normal left ventricular ejection fractions but diastolic dysfunction develop congestive heart failure because of underlying renal insufficiency. A larger, prospective study is needed to confirm this hypothesis. Copyright © 2010 Wiley Periodicals, Inc.

The authors have no funding, financial relationships, or conflicts of interest to disclose.
Confidential Testing of Cardiac Examination Competency in Cardiology and Noncardiology Faculty and Trainees: A Multicenter Study
Authors: Vukanovic‐Criley Jasminka M. , Hovanesyan Arsen , Criley Stuart Ross , Ryan Thomas J. , Plotnick Gary , Mankowitz Keith , Conti C. Richard , Criley John Michael
Published: December 2010

Background:

Many reported studies of medical trainees and physicians have demonstrated major deficiencies in correctly identifying heart sounds and murmurs, but cardiologists had not been tested. We previously confirmed these deficiencies using a 50‐question multimedia cardiac examination (CE) test featuring video vignettes of patients with auscultatory and visible manifestations of cardiovascular pathology (virtual cardiac patients). Previous testing of 62 internal medical faculty yielded scores no better than those of medical students and residents.

Hypothesis:

In this study, we tested whether cardiologists outperformed other physicians in cardiac examination skills, and whether years in practice correlated with test performance.

Methods:

To obviate cardiologists' reluctance to be tested, the CE test was installed at 19 US teaching centers for confidential testing. Test scores and demographic data (training level, subspecialty, and years in practice) were uploaded to a secure database.

Results:

The 520 tests revealed mean scores (out of 100 ± 95% confidence interval) in descending order: 10 cardiology volunteer faculty (86.3 ± 8.0), 57 full‐time cardiologists (82.0 ± 3.3), 4 private‐practice cardiologists (77.0 ± 6.8), and 19 noncardiology faculty (67.3 ± 8.8). Trainees' scores in descending order: 150 cardiology fellows (77.3 ± 2.1), 78 medical students (63.7 ± 3.5), 95 internal medicine residents (62.7 ± 3.2), and 107 family medicine residents (59.2 ± 3.2). Faculty scores were higher in those trained earlier with longer practice experience.

Conclusions:

Academic and volunteer cardiologists outperformed other medical faculty, as did cardiology fellows. Lower scores were observed in more recently trained faculty. Remote testing yielded scores similar to proctored tests in comparable groups previously studied. No significant improvement was seen after medical school with residency training. Copyright © 2010 Wiley Periodicals, Inc.

This study was supported by grants 1R43HL062841‐01A1, 2R44HL062841‐02, and 2R44HL062841‐03 from the National Heart, Lung, and Blood Institute, Bethesda, MD. The funding source was not involved in the design and conduct of the study; collection, management, analysis, and interpretation of the data; and preparation, review, or approval of the manuscript. The authors have no other funding, financial relationships, or conflicts of interest to disclose.
Apoptosis induction through proteasome inhibitory activity of cucurbitacin D in human T‐cell leukemia
Authors: Ding Ning , Yamashita Uki , Matsuoka Hidetada , Sugiura Tsutomu , Tsukada Junichi , Noguchi Junko , Yoshida Yasuhiro
Published: December 2010

BACKGROUND:

Human T‐cell leukemia is an aggressive malignancy of T lymphocytes. T‐cell leukemia has a very poor prognosis, even with intensive chemotherapy, indicating the need for development of new drugs to treat the disease. Triterpenoid cucurbitacins have been shown to have antitumor activity, but the mechanism of this activity is not fully understood.

METHODS:

The effects of cucurbitacin D on the proliferation and apoptotic induction of T‐cell leukemia cells using the Cell viability assay and Annexin V staining were evaluated. To investigate the mechanisms of apoptosis, antiapoptotic protein, NF‐κB, and the proteasome activity of leukemia cells treated with cucurbitacin D were evaluated by Western blotting both in vitro and in vivo.

RESULTS:

In this study, cucurbitacin D was found to inhibit proliferation and to induce apoptosis of T‐cell leukemia cells. Constitutively activated NF‐κB was inhibited by cucurbitacin D in the nucleus, which resulted in accumulation of NF‐κB in the cytoplasm, leading to down‐regulation of the expression of antiapoptotic proteins Bcl‐xL and Bcl‐2. Furthermore, cucurbitacin D induced the accumulation of inhibitor of NF‐κB (IκB)α by inhibition of proteasome activity. Low doses of cucurbitacin D synergistically potentiated the antiproliferative effects of the histone deacetylase inhibitor VPA. Finally, the proapoptotic and proteasome inhibitory activities of cucurbitacin D also were demonstrated using SCID mice in an in vivo study.

CONCLUSIONS:

Cucurbitacin D induced apoptosis through suppression of proteasome activity both in vitro and in vivo, making cucurbitacin D a promising candidate for clinical applications in the treatment of T‐cell leukemia. Cancer 2011;. © 2010 American Cancer Society.
Prognostic significance of RUNX3 expression in human melanoma
Authors: Zhang Zhizhong , Chen Guangdi , Cheng Yabin , Martinka Magdalena , Li Gang
Published: December 2010

BACKGROUND:

RUNX3 is a tumor suppressor that plays important roles in cell proliferation, apoptosis, and metastasis. The authors investigated the role of RUNX3 in melanoma pathogenesis and analyzed the prognostic impact of RUNX3 expression in a large series of melanoma patients.

METHODS:

Two sets of tissue microarrays were constructed, including 440 cases of melanomas (202 for the training set and 238 for the validation set) and 88 cases of nevi (25 normal nevi and 63 dysplastic nevi). RUNX3 expression was evaluated by immunohistochemistry.

RESULTS:

Positive RUNX3 expression was observed in 56%, 54%, 33%, and 24% of the biopsies in normal nevi, dysplastic nevi, primary melanoma, and melanoma metastases, respectively. Significant differences for positive nuclear RUNX3 staining were observed between dysplastic nevi and primary melanomas (P = .002, chi‐square test), between dysplastic nevi and melanoma metastases (P < .001, chi‐square test), and between primary melanoma and melanoma metastases (P = .045, chi‐square test). Loss of RUNX3 expression was correlated with a worse 5‐year survival of melanoma patients in both training and validation sets. Furthermore, loss of RUNX3 expression was also correlated with a poor 5‐year disease‐specific survival in primary melanoma (P = .001) and metastatic melanoma patients (P = .008). Multivariate Cox regression analysis revealed that positive RUNX3 expression is an independent prognostic factor to predict melanoma patient outcome.

CONCLUSIONS:

Our findings indicate that RUNX3 plays an important role in melanoma pathogenesis and may serve as a promising prognostic marker for melanoma. Cancer 2011;. © 2010 American Cancer Society.
Up‐regulation and clinical significance of serine protease kallikrein 6 in colon cancer
Authors: Kim Jong‐Tae , Song Eun Young , Chung Kyung‐Sook , Kang Min Ah , Kim Jae Wha , Kim Sang Jick , Yeom Young Il , Kim Joo Heon , Kim Kyo Hyun , Lee Hee Gu
Published: December 2010

BACKGROUND:

Kallikrein‐related peptidase 6 (KLK6) encodes a trypsin‐like serine protease that is up‐regulated in several cancers, although the putative functions of KLK6 in cancer have not been elucidated. In the current study, overexpression of KLK6 was identified in colon cancer, and the possibility that KLK6 may be a suitable candidate as a tumor marker was examined.

METHODS:

Messenger RNA (mRNA) transcript levels and protein up‐regulation of KLK6 in colon cancer tissues was examined using reverse transcriptase‐polymerase chain reaction, immunohistochemistry, and clinicopathologic analyses. Cell proliferation, invasiveness, and antiapoptotic activity were determined in colon cancer cells that were transfected with small‐interfering RNA (siRNA) of KLK6.

RESULTS:

KLK6 mRNA was up‐regulated significantly in tumor tissues compared with nontumor regions. KLK6 protein was strongly expressed in adenocarcinomas but was not expressed in normal mucosa or in premalignant dysplastic lesions. Sera from patients with colon cancer revealed an increase in KLK6 secretion (0.25 μg/mL; P = .031) compared with noncancer cells (0.19 μg/mL). Clinicopathologic and immunohistochemical studies of 143 patients with colon cancer revealed a significant correlation between KLK6 expression and Dukes disease stage (P = .005). High KLK6 expression was associated significantly with shorter overall (P = .001) and recurrence‐free survival (P = .001). The rates of proliferation and invasiveness were decreased by 50% in cells that were transfected with KLK6 siRNA. The overexpression of KLK6 led to decreased activity of the E‐cadherin promoter.

CONCLUSIONS:

KLK6 was up‐regulated significantly in tissues and sera from patients with colon cancer and was associated closely with a poor prognosis, suggesting that KLK6 may be used as a potential biomarker and a therapeutic target for colon cancer. Cancer 2011;. © 2010 American Cancer Society.
Spatiotemporal fate map of neurogenin1 (Neurog1) lineages in the mouse central nervous system
Authors: Kim Euiseok J. , Hori Kei , Wyckoff Alex , Dickel Lauren K. , Koundakjian Edmund J. , Goodrich Lisa V. , Johnson Jane E.
Published: December 2010

Neurog1 (Ngn1, Neurod3, neurogenin1) is a basic helix‐loop‐helix (bHLH) transcription factor essential for neuronal differentiation and subtype specification during embryogenesis. Due to the transient expression of Neurog1 and extensive migration of neuronal precursors, it has been challenging to understand the full complement of Neurog1 lineage cells throughout the central nervous system (CNS). Here we labeled and followed Neurog1 lineages using inducible Cre‐flox recombination systems with Neurog1‐Cre and Neurog1‐CreERT2 BAC (bacterial artificial chromosome) transgenic mice. Neurog1 lineage cells are restricted to neuronal fates and contribute to diverse but discrete populations in each brain region. In the forebrain, Neurog1 lineages include mitral cells and glutamatergic interneurons in the olfactory bulb, pyramidal and granule neurons in the hippocampus, and pyramidal cells in the cortex. In addition, most of the thalamus, but not the hypothalamus, arises from Neurog1 progenitors. Although Neurog1 lineages are largely restricted to glutamatergic neurons, there are multiple exceptions including Purkinje cells and other GABAergic neurons in the cerebellum. This study provides the first overview of the spatiotemporal fate map of Neurog1 lineages in the CNS. J. Comp. Neurol. 519:1355–1370, 2011. © 2010 Wiley‐Liss, Inc.