bluuebunny/crossref_metadata_2025 huggingface dataset:
The Integration of Deep Learning in Radiotherapy: Exploring Challenges, Opportunities, and Future Directions through an Umbrella Review
Authors: Lastrucci Andrea , Wandael Yannick , Ricci Renzo , Maccioni Giovanni , Giansanti Daniele
Published: May 2024

This study investigates, through a narrative review, the transformative impact of deep learning (DL) in the field of radiotherapy, particularly in light of the accelerated developments prompted by the COVID-19 pandemic. The proposed approach was based on an umbrella review following a standard narrative checklist and a qualification process. The selection process identified 19 systematic review studies. Through an analysis of current research, the study highlights the revolutionary potential of DL algorithms in optimizing treatment planning, image analysis, and patient outcome prediction in radiotherapy. It underscores the necessity of further exploration into specific research areas to unlock the full capabilities of DL technology. Moreover, the study emphasizes the intricate interplay between digital radiology and radiotherapy, revealing how advancements in one field can significantly influence the other. This interdependence is crucial for addressing complex challenges and advancing the integration of cutting-edge technologies into clinical practice. Collaborative efforts among researchers, clinicians, and regulatory bodies are deemed essential to effectively navigate the evolving landscape of DL in radiotherapy. By fostering interdisciplinary collaborations and conducting thorough investigations, stakeholders can fully leverage the transformative power of DL to enhance patient care and refine therapeutic strategies. Ultimately, this promises to usher in a new era of personalized and optimized radiotherapy treatment for improved patient outcomes.
Hair Evaluation in Orthodontic Patients with Oligodontia
Authors: Zadurska Małgorzata , Rakowska Adriana , Czochrowska Ewa , Laskowska Małgorzata , Perkowski Konrad , Strużycka Izabela , Rudnicka Lidia , Jurek Agnieszka
Published: May 2024

Oligodontia can be isolated or syndromic, associated with other ectodermal abnormalities. The aim of the study was to perform hair examination in orthodontic patients diagnosed with oligodontia with a low clinical expression of symptoms of ectodermal origin. All available orthodontic patients diagnosed with oligodontia in the permanent dentition were enrolled. Hair examination included clinical evaluation of the patients’ hair, trichoscopy, trichogram and evaluation of the hair shafts under a polarized light microscope. In total, 25 patients, 18 males and 7 females, aged 6 to 24 years were evaluated for the presence of dental and hair abnormalities. The number of congenitally absent teeth ranged from 6 to 24 teeth and diastemas, microdontia, taurodontism and altered tooth shape were found in 23 patients. Hair disorders were found in 68% of the subjects. Hypotrichosis, the heterogeneity of shaft color and loss of pigment, androgenetic alopecia, telogen effluvium, trichoschisis, pili canaliculi, trichorrhexis nodosa and pseudomoniletrix were observed. Trichoscopy and trichogram are valid non-invasive diagnostic tests which could be used to differentiate between isolated and syndromic oligodontia in patients with a low clinical expression of ectodermal symptoms.
Urinary Epidermal Growth Factor Level as a Noninvasive Indicator of Tubular Repair in Patients with Acute Kidney Injury
Authors: Ono Kazutoshi , Maeshima Akito , Nagayama Izumi , Kubo Taro , Yagisawa Takashi , Nagata Daisuke
Published: May 2024

Epidermal growth factor (EGF), an essential factor for the proliferation and survival of renal tubular cells, is expressed by distal tubules and normally excreted via urine. Previous studies in rats demonstrated that acute tubular injury reduces urinary EGF levels. However, it is unclear whether urinary EGF is a suitable monitoring marker of tubular repair status after acute kidney injury (AKI) in humans. To address this question, we measured serum and urinary EGF in patients with AKI (n = 99) using ELISA and investigated whether urinary EGF levels were associated with the severity of tubular injury and renal prognosis. Urinary EGF was abundant in healthy controls but showed a significant decrease in AKI patients (14,522 ± 2190 pg/mL vs. 3201 ± 459.7 pg/mL, p < 0.05). The urinary EGF level in patients with renal AKI was notably lower than that in patients with pre-renal AKI. Furthermore, the urinary EGF level in patients with AKI stage 3 was significantly lower than that in patients with AKI stage 1. Urinary EGF levels were negatively correlated with urinary β-2MG and serum creatinine levels but positively correlated with hemoglobin levels and eGFR. Urinary EGF was not significantly correlated with urinary NAG, α-1MG, L-FABP, NGAL, KIM-1, or urinary protein concentrations. No significant correlation was observed between serum and urinary EGF levels, suggesting that urinary EGF is derived from the renal tubules rather than the blood. In living renal transplantation donors, the urinary EGF/Cr ratio was approximately half the preoperative urinary EGF/Cr ratio after unilateral nephrectomy. Collectively, these data suggest that urinary EGF is a suitable noninvasive indicator of not only the volume of functional normal renal tubules but also the status of tubular repair after AKI.
Advanced Swine Management: Infrared Imaging for Precise Localization of Reproductive Organs in Livestock Monitoring
Authors: Almadani Iyad , Ramos Brandon , Abuhussein Mohammed , Robinson Aaron L.
Published: May 2024

Traditional methods for predicting sow reproductive cycles are not only costly but also demand a larger workforce, exposing workers to respiratory toxins, repetitive stress injuries, and chronic pain. This occupational hazard can even lead to mental health issues due to repeated exposure to violence. Managing health and welfare issues becomes pivotal in group-housed animal settings, where individual care is challenging on large farms with limited staff. The necessity for computer vision systems to analyze sow behavior and detect deviations indicative of health problems is apparent. Beyond observing changes in behavior and physical traits, computer vision can accurately detect estrus based on vulva characteristics and analyze thermal imagery for temperature changes, which are crucial indicators of estrus. By automating estrus detection, farms can significantly enhance breeding efficiency, ensuring optimal timing for insemination. These systems work continuously, promptly alerting staff to anomalies for early intervention. In this research, we propose part of the solution by utilizing an image segmentation model to localize the vulva. We created our technique to identify vulvae on pig farms using infrared imagery. To accomplish this, we initially isolate the vulva region by enclosing it within a red rectangle and then generate vulva masks by applying a threshold to the red area. The system is trained using U-Net semantic segmentation, where the input for the system consists of grayscale images and their corresponding masks. We utilize U-Net semantic segmentation to find the vulva in the input image, making it lightweight, simple, and robust enough to be tested on many images. To evaluate the performance of our model, we employ the intersection over union (IOU) metric, which is a suitable indicator for determining the model’s robustness. For the segmentation model, a prediction is generally considered ‘good’ when the intersection over union score surpasses 0.5. Our model achieved this criterion with a score of 0.58, surpassing the scores of alternative methods such as the SVM with Gabor (0.515) and YOLOv3 (0.52).
Computational Fluid Dynamics Methodology to Estimate the Drag Coefficient of Balls in Rolling Element Bearings
Authors: Marchesse Yann , Changenet Christophe , Ville Fabrice
Published: May 2024

The emergence of electric vehicles has brought new issues such as the problem of rolling element bearings (REBs) operating at high speeds. Losses due to these components in mechanical transmissions are a key issue and must therefore be taken into account right from the design stage of these systems. Among these losses, the one induced by the motion of rolling elements, known as drag loss, becomes predominant in high-speed REBs. Although an experimental approach is still possible, it is difficult to isolate this loss in order to study it properly. A numerical approach based on CFD is therefore a possible way forward, even if other issues arise. The aim of this article is to study the ability of such an approach to correctly estimate the drag coefficient associated with the motion of rolling elements. The influence of the numerical domain extension, the mesh refinement, the simplification of the ring shape, and the presence of the cage on the values of the drag coefficient is presented. While it seems possible to compromise on the calculation domain and mesh size, it appears that the other parameters must be taken into account as much as possible to obtain realistic results.
Lie Symmetries of the Wave Equation on the Sphere Using Geometry
Authors: Tsamparlis Michael , Ukpong Aniekan Magnus
Published: May 2024

A semilinear quadratic equation of the form Aij(x)uij=Bi(x,u)ui+F(x,u) defines a metric Aij; therefore, it is possible to relate the Lie point symmetries of the equation with the symmetries of this metric. The Lie symmetry conditions break into two sets: one set containing the Lie derivative of the metric wrt the Lie symmetry generator, and the other set containing the quantities Bi(x,u),F(x,u). From the first set, it follows that the generators of Lie point symmetries are elements of the conformal algebra of the metric Aij, while the second set serves as constraint equations, which select elements from the conformal algebra of Aij. Therefore, it is possible to determine the Lie point symmetries using a geometric approach based on the computation of the conformal Killing vectors of the metric Aij. In the present article, the nonlinear Poisson equation Δgu−f(u)=0 is studied. The metric defined by this equation is 1 + 2 decomposable along the gradient Killing vector ∂t. It is a conformally flat metric, which admits 10 conformal Killing vectors. We determine the conformal Killing vectors of this metric using a general geometric method, which computes the conformal Killing vectors of a general 1+(n−1) decomposable metric in a systematic way. It is found that the nonlinear Poisson equation Δgu−f(u)=0 admits Lie point symmetries only when f(u)=ku, and in this case, only the Killing vectors are admitted. It is shown that the Noether point symmetries coincide with the Lie point symmetries. This approach/method can be used to study the Lie point symmetries of more complex equations and with more degrees of freedom.
The Effects of an Entrepreneurial Project on the Career-Choice Readiness, Metacognition, and Growth Mindset of Secondary Students
Authors: Brausch-Böger Maxi Eileen , Förster Manuel
Published: May 2024

The present study evaluated the effect of a four-day entrepreneurial project on the career-choice readiness of secondary school students. The hypotheses underlying this study state that participation in a school startup project increases the students’ career-choice readiness, growth mindset, and metacognition. Based on the literature, it is also assumed that a positive correlation exists between metacognition, growth mindset, and career-choice readiness. The present study examined a student entrepreneurship program by conducting a pre–post design. School classes developed and implemented business ideas with qualified coaches within the program based on a comprehensive didactic approach. Data from each group of participants were collected at two measurement time points. The results demonstrated that the values for all constructs increased in the post-test after participating in the entrepreneurial intervention. Furthermore, the findings indicate that a growth mindset is related to career-choice readiness and mediates the relationship between career-choice readiness and metacognition. Moreover, metacognition additionally favors a growth mindset. Based on the findings, entrepreneurial projects at schools are helpful for vocational orientation and should be extended by cooperating with external organizations and partners.
Decentralized Fuzzy Fault Estimation Observer Design for Discrete-Time Nonlinear Interconnected Systems
Authors: Koo Geun Bum
Published: May 2024

In this paper, a fault estimation technique is proposed for discrete-time nonlinear interconnected systems with uncertain interconnections. To achieve the fault estimation, the decentralized fuzzy observer is adopted based on the Takagi–Sugeno fuzzy model. Based on the estimation error model with the subsystems of the interconnected system and its decentralized fuzzy observer, the fault estimation condition with H∞ performance is presented. The main idea of this paper is that a novel inequality condition for H∞ performance is used, and the sufficient condition is presented to guarantee the good fault estimation performance. Also, the decentralized fuzzy observer design condition for the fault estimation is converted into linear matrix inequality formats. Finally, a simulation example is provided, and the effectiveness of the proposed fault estimation technique is verified by comparison of the fault estimation performance.
Fast Coding Unit Partitioning Algorithm for Video Coding Standard Based on Block Segmentation and Block Connection Structure and CNN
Authors: Li Nana , Wang Zhenyi , Zhang Qiuwen
Published: May 2024

The recently introduced Video Coding Standard, VVC, presents a novel Quadtree plus Nested Multi-Type Tree (QTMTT) block structure. This structure enables a more flexible block partition and demonstrates enhanced compression performance compared to its predecessor, HEVC. However, The introduction of the new structure has led to a more complex partition search process, resulting in a considerable increase in time complexity. The QTMTT structure yields diverse Coding Unit (CU) block sizes, posing challenges for CNN model inference. In this study, we propose a representation structure termed Block Segmentation and Block Connection (BSC), rooted in texture features. This ensures that partial CU blocks are uniformly represented in size. To address different-sized CUs, various levels of CNN models are designed for prediction. Moreover, we introduce a post-processing method and a multi-thresholding scheme to further mitigate errors introduced by CNNs. This allows for flexible and adjustable acceleration, achieving a trade-off between coding time complexity and performance. Experimental results indicate that, in comparison to VTM-10.0, our “Fast” scheme reduces the average complexity by 57.14% with a 1.86% increase in BDBR. Meanwhile, the “Moderate” scheme reduces average complexity by 50.14% with only a 1.39% increase in BDBR.
Research on Thermal Adaptability of Flexible Operation in Different Types of Coal-Fired Power Units
Authors: Wei Haijiao , Lu Yuanwei , Yang Yanchun , Wu Yuting , Zheng Kaifeng , Li Liang
Published: May 2024

The flexible mode of operation of coal-fired units can accommodate large-scale renewable power integration into the grid, providing more grid capacity. The flexibility transformation of coal-fired units in thermal power plants can be achieved through main steam extraction and reheated steam extraction. A 300 MW subcritical unit, 600 MW subcritical unit and 660 MW ultra-supercritical unit with six flexible operation modes were chosen as the research model to investigate the thermal adaptability for flexible operation. The results show that from the perspective of the source of steam extraction, the main steam extraction scheme is suitable for the flexible adjustment of peak load capacity, and the reheated extraction scheme is suitable for the flexible operation of low load and high thermal efficiency. Moreover, from the perspective of thermal performance adaptability, the 600 MW unit has a wider load regulation capacity than the 300 MW and 660 MW units, and is suitable as the peak shaving unit. This work can provide theoretical guidance for different types of coal-fired units in choosing flexible operation schemes.
Increased Psychological Symptoms and Autonomic Arousal in Patients with Subclinical Hypothyroidism: A Case–Control Study
Authors: Guidotti Sara , Innocenti Augusto , Cosentino Chiara , Monzani Fabio , Guccini Irene , Pruneti Carlo
Published: May 2024

(1) Background: Subclinical hypothyroidism (SHT) is a condition that has been a subject of controversy in the literature due to its association with psychological and psychiatric symptoms as well as autonomic imbalances. To gain a better understanding of the effects of SHT on patients, a research study has been undertaken to investigate the presence of psychological symptoms and autonomic imbalances in a group of individuals diagnosed with SHT. (2) Methods: In this case–control study, 50 patients diagnosed with SHT who accessed the Department of Endocrinology of the University of Pisa were consecutively recruited. Psychological symptoms were measured through the Crown–Crisp Experiential Index (CCEI), whereas autonomic imbalance was described using the Psychophysiological Stress Profile (PSP), with simultaneous recording of the following psychophysiological parameters: Surface Electromyogram (sEMG), Skin Conductance Level (SCL), heart rate (HR), and peripheral temperature (PT). The patients’ values were compared to those of 50 healthy control subjects. (3) Results: The comparison between groups highlighted significant differences in the CCEI and PSP. In particular, patients reported higher rates of psychological symptoms (anxiety, depression, somatic complaints, and hysteria behavior). Significantly higher levels of autonomic arousal were also recorded. More specifically, the sEMG, SCL, HR, and PT values were different between the two groups. (4) Conclusions: The study has confirmed the presence of autonomic hyperarousal in patients diagnosed with subclinical hypothyroidism. This is likely due to the body’s attempt to compensate for a general lack of energy by accelerating the autonomic activity. The findings also underline the significance of a comprehensive assessment approach that takes into account various dimensions such as psychological and psychophysical well-being. Such an approach helps in evaluating the impact of subclinical diseases on overall health and well-being.
Aquatic Bacterial Community Connectivity: The Effect of Hydrological Flow on Community Diversity and Composition
Authors: Sadeghi Javad , Venney Clare J. , Wright Shelby , Watkins James , Manning Dana , Bai Edel , Frank Chelsea , Heath Daniel D.
Published: May 2024

Microbial communities are vital components of freshwater ecosystems due to their role in nutrient cycling and energy flow; however, the mechanisms driving their variation are still being explored. In aquatic systems, water flow (hydrology) can impact microbial community composition through community connectivity; however, the details of hydrology’s effects on microbial connectivity remain unclear. To address this question, we used 16S rRNA metabarcoding to determine bacterial community composition and connectivity across flow transects in three connected Great Lakes waterbodies with very different water-flow regimes: the Little River (high flow), the Detroit River (moderate flow), and Lake Erie (low flow). Bacterial alpha diversity (Chao1) did not differ among the three locations or sample sites along the transects. Analyses of beta diversity using community dissimilarity matrices identified significant differences among the three locations and among sample sites within locations. Bacterial community connectivity varied among the three locations, with a significant distance–decay relationship observed only in the low-flow location, which is indicative of connectivity driven by spatial proximity. Directional analyses showed that the water-flow direction affected bacterial similarity, consistent with the expected hydrological effects on community connectivity and previous published work. Our results indicate that (1) microbial community composition varies within and among even geographically close sampling locations and (2) the specific water-flow regime appears to affect bacterial community connectivity. Including hydrology in models of bacterial community composition will improve our understanding of the relative roles of selection versus stochastic effects on bacterial community diversity and composition in freshwater ecosystems.
Roe Deer, Lithuania’s Smallest and Most Abundant Cervid
Authors: Balčiauskas Linas
Published: May 2024

A review of 113 scientific and other publications on the smallest and most abundant deer in Lithuania, the roe deer (Capreolus capreolus), is presented, along with an analysis based on compound annual population growth rates of population numbers, hunting bags, and roadkill. This review covers the species’ history in the country from the last glaciation onwards, the changes in numbers from 1934 to 2023, hunting bag changes from 1965 to 2022, roadkill numbers from 2002 to 2022, data on roe deer reproduction, habitat selection, genetic diversity, pathogens, and damage to forest stands. It also provides an overview of species management and selection for trophies. Despite the exponential increase in roe deer numbers since 1990 and the dominance of this species in roadkill, even on urban roads, the number and density of animals and the damage they cause to forest stands are relatively low compared to other European countries. Within the observed period, drops in numbers were related to harsh winters in 1969/1970 and 1995/1996. Poaching, especially coinciding with weakened enforcement during the period of political–economic transition in the early 1990s, has also had a negative impact on population numbers, as have recent increases in the number of large predators. Population growth over the recent period does not correlate with hunting mortality, which has remained stable at an average of 16.9% since 2002.
The Effect of Wet and Dry Cycles on the Strength and the Surface Characteristics of Coromandel Lacquer Coatings
Authors: Liu Wenjia , Zhu Ling , Varodi Anca Maria , Liu Xinyou , Lv Jiufang
Published: May 2024

Research on the degradation mechanism of coating materials is crucial for the preservation of cultural heritage. The purpose of this study was to evaluate the protective effect of Coromandel coatings on wooden substrates by analyzing their dimensions, weight, adhesion strength, hydrophobicity, and glossiness. The results indicate that after five cycles, the radial moisture expansion rate of the wood specimen is 0.332%, while that of the lacquer specimen is 0.079%, representing 23.8% of the radial moisture expansion rate of untreated wood specimens. This performance is superior to that of the ash and pigment specimens. Across different experimental conditions, the change in the mass of the Coromandel specimens aligns with the trend in their dimensional changes, indicating that moisture absorption and desorption are the primary reasons for dimensional changes. The influence of temperature on mass and dimensional stability is significant only in terms of dry shrinkage rate. After wet and dry cycles at 40 °C, the adhesion strength of the Coromandel specimens decreases the most, with the ash specimens decreasing by 7.2%, the lacquer specimens by 3.2%, and the pigment specimens by 4.5%. Following wet and dry cycles at three different temperatures, the contact angle of the lacquer layers changes by less than 5%, with their contact angle values exceeding 120°. These data indicate that among the Coromandel coatings, the lacquer layer provides the best protection for the wooden substrate, while the ash coating is the most fragile. The degradation rate of the Coromandel specimens increases with rising temperatures. These findings emphasize the critical roles of humidity and temperature in protecting wooden coatings and aim to provide theoretical insights and practical significance for the preservation of wooden artifacts and the assessment of coating performance.
The Effect of Technological Progress on Yarder Productivity: An Example from the Bulgarian Mountains
Authors: Spinelli Raffaele , Glushkov Sotir , Findeisen Erik , Boyadzhiev Dimitar , Markoff Ivailo
Published: May 2024

In recent years, a significant import of modern tower yarders has been registered in Bulgaria, where official productivity standards are routinely used for operational planning and control. Given the higher potential of the newer yarder models, the Bulgarian forestry sector has started a review of the older productivity standards dating back to the 1970s. This new endeavor has offered an ideal opportunity for gauging the effect of technological progress in yarder technology. Therefore, the authors have used the very first results achieved during the development of the new standards for conducting a preliminary quantitative comparison between older and newer yarder types. Modern yarders (e.g., Konrad Mounty 4000) are much faster than the older ones (e.g., Koller K300), and their time consumption per cubic meter is half as large, especially on longer distances. At short distances, however, their performance evens out. Regardless of the distance, the installation time of the Konrad Mounty 4000 is twice as short. As they are largely automated, the new machines can be manned by smaller crews (e.g., two workers instead of three) and are easier and safer to operate. Finally, the new machines are equipped with built-in loaders and processors, which allows them to integrate delimbing, crosscutting and stacking within the same work cycle. With older models, a separate team must be deployed for those tasks.
Sustainable Afforestation Strategies: Hybrid Multi-Criteria Decision-Making Model in Post-Mining Rehabilitation
Authors: Güngör Ersin , Şen Gökhan
Published: May 2024

This article describes an effective approach for selecting suitable plant species for afforestation in post-mining rehabilitation. The research was conducted in the Western Black Sea region of Turkey. The aim of the research is to perform accurate criteria weighting and species prioritization for afforestation in post-mining degraded areas. This helps to ensure consistent conditions for the future use of the site as a forest, sustainability of nature, and selection of appropriate species adapted to the difficult post-mining conditions. In this study, which is a multi-criteria decision-making problem (MCDM), the weights of the criteria were determined by stepwise weight assessment ratio analysis (SWARA), and the priority ranking of the species was determined by the analytic hierarchy process (AHP). Analyses were carried out with 10 afforestation criteria and five tree species. According to the analysis, the top three ranked criteria are Economic Efficiency > Carbon Stock and Credit > Reducing Afforestation Cost. The five species’ priority ranking is Robinia pseudoacacia L. (0.456) > Alnus glutinosa subsp. glutinosa (0.248) > Populus nigra subsp. nigra (0.146) > Salix alba L. (0.103) > Quercus robur subs. robur (0.048). The hybrid approach is expected to increase the effectiveness of post-mining rehabilitation works.
Comparative Study of Single-Wood Biomass Model at Plot Level Based on Multi-Source LiDAR
Authors: Zhang Ying , Xue Siyu , Liu Shengqiu , Li Xianliang , Fan Qijun , Xiong Nina , Wang Jia
Published: May 2024

Forests play an important role in promoting carbon cycling and mitigating the urban heat island effect as one of the world’s major carbon storages. Scientifically quantifying tree biomass is the basis for assessing tree carbon storage and other ecosystem functions. In this study, a sample plot of Populus tomentosa plantation in the Olympic Forest Park in Beijing was selected as the research object. Point cloud data from three types of laser scanners, including terrestrial laser scanner (TLS), backpack laser scanner (BLS), and handheld laser scanner (HLS), were used to estimate the biomass of single tree trunks, branches, leaves, and aboveground total biomass based on the Allometric Biomass Model (ABM) and Advanced Quantitative Structure Model (AdQSM). The following conclusions were drawn from the estimation results: (1) For the three types of laser scanner point clouds, the biomass estimation values obtained using the AdQSM model were generally higher than those obtained using the Allometric Biomass Model. However, the estimation values obtained using the two models were similar, especially for tree trunks and total biomass. (2) For total biomass and individual biomass components of single trees, the results obtained from handheld and terrestrial laser scanner point clouds are consistent; however, they show some differences from the results obtained from backpack-mounted point clouds. This study further enriches the methodological system for estimating forest biomass, providing a theoretical basis and reference for more accurate estimates of forest biomass and more sustainable forest management.
Genetic Basis for Morphological Variation in the Zebrafish Danio rerio: Insights from a Low-Heterozygosity Line
Authors: Martinez-Bautista Gil , Padilla Pamela , Burggren Warren W.
Published: May 2024

Data variability complicates reproducibility and the interpretation of experimental results. Different animal models have been employed to decrease variability to enhance experimental power. However, variation frequently persists among and within strains/lines. In zebrafish (Danio rerio), inbred lines (e.g., NHGRI-1) derived from wild-type lines have been produced to greatly decrease genetic variation, with the goal of providing better understanding of genetic backgrounds that may influence the experimental outcome of studies employing such lines. We hypothesized that variations in morphological phenotypes shaped by environmental stressors early in development are correlated with the intrinsic degree of genetic variability of zebrafish lines. We compared morphological variability (yolk–chorion ratio, body mass, embryo mass, total length, condition factor, and specific growth rate) in wild-type AB and NHGRI-1 zebrafish lines as a function of their responses to altered temperature and oxygen availability during the first 7 days post-fertilization. Overall, both lines showed similar developmental trajectories for yolk–chorion ratio, embryo mass, and total length. Additionally, condition factor and specific growth rate showed similar responses within each line, regardless of temperature and hypoxia. Importantly, the coefficient of variation for each variable was significantly lower in NHGRI-1 than AB larvae for 151 of 187 assessed morphological endpoints. Thus, the low-heterozygosity NHGRI-1 zebrafish line can be useful for decreasing inter-individual variation in morphological responses to environmental stressors, thereby aiding in the interpretation of results and enhancing experimental reproducibility.
Production of Margarine Fat Containing Medium- and Long-Chain Triacylglycerols by Enzymatic Interesterification of Peony Seed Oil, Palm Stearin and Coconut Oil Blends
Authors: Zhang Man , Xu Baocheng , Zhao Dongkun , Shen Mengqi , Li Mengjie , Liu Donghao , Liu Lili
Published: May 2024

This paper reports the preparation of margarine fat using Lipozyme TL IM as a catalyst and peony seed oil (PSO), palm stearin (PS) and coconut oil (CO) as raw materials. The results indicate that there were no significant changes in fatty acid composition before or after interesterification of the oil samples. However, the total amount of medium- and long-chain triglycerides (MLCTs) increased from 2.92% to 11.38% in sample E1 after interesterification, mainly including LaLaO, LaMO, LaPM, LaOO, LaPO and LaPP. Moreover, the slip melting point (SMP) of sample E1 decreased from 45.9 °C (B1) to 33.5 °C. The solid fat content (SFC) of all the samples at 20 °C was greater than 10%, indicating that they could effectively prevent oil exudation. After interesterification, the samples exhibited a β′ crystal form and could be used to prepare functional margarine.
Characterization and Performance Analysis of Hydrolyzed versus Non-Hydrolyzed Poly(NVF-co-HEA) Hydrogels for Cosmetic Applications
Authors: Yooyod Maytinee , Pinthong Thanyaporn , Mahasaranon Sararat , Viyoch Jarupa , Ross Sukunya , Ross Gareth M.
Published: May 2024

This study explores the synthesis and modification of poly(N-vinylformamide-co-N-hydroxyethyl acrylamide) (poly(NVF-co-HEA)) hydrogels for cosmetic applications. Poly(NVF-co-HEA) hydrogels were produced followed by an acid hydrolysis reaction to produce poly(NVF-co-VAm-co-HEA) hydrogels, introducing poly(vinyl amine) (PVAm) into the structure. This modification considerably alters the hydrogels’ properties, yielding materials with over 96% water content, predominantly in the form of non-freezing or free water, which is beneficial in the uptake and release of hydrophilic species. The primary amine groups from inclusion of VAm also improved the mechanical properties, as evidenced by an 8-fold increase in Young’s modulus. The hydrogels also possessed pH-responsive behavior, which was particularly noticeable under acidic and basic conditions, where a large decrease in water content was observed (40% to 75% reduction). Characterizing the hydrogels’ release capabilities involved using organic dyes of different functional groups and sizes to examine the pH impact on release. The results indicated that hydrolyzed hydrogels interacted more effectively with charged species, highlighting their suitability for pH-responsive delivery. The release of cosmetic active ingredients was also demonstrated through the controlled release of Liquid Azelaic™, specifically potassium azeloyl diglycinate (PAD). Our findings reveal that the hydrolyzed hydrogels exhibit superior burst release, especially under alkaline conditions, suggesting their suitability for cosmetic applications where controlled, pH-responsive delivery of active ingredients is desired. Overall, this investigation highlights the potential of hydrolyzed poly(NVF-co-HEA) hydrogels in cosmetic applications. Their ability to combine high water content with mechanical integrity, along with their pH-responsive release ability, allows for use in cosmetic formulations.
Group Intervention Program to Facilitate Post-Traumatic Growth and Reduce Stigma in HIV
Authors: Tomaz Santos Nuno , Ramos Catarina , de Almeida Margarida Ferreira , Leal Isabel
Published: May 2024

Background: Research on post-traumatic growth (PTG) and HIV is scarce and the relationship between PTG and stigma is controversial. Group psychotherapeutic interventions to facilitate PTG in clinical samples are effective but none exist to simultaneously decrease stigma in the HIV population. The main objective was to evaluate the effectiveness of an intervention in increasing PTG and decreasing stigma in HIV, as well as to explore relationships between the variables. Methods: Quasi-experimental design with a sample of 42 HIV-positive adults (M = 46.26, SD = 11.90). The experimental group (EG) was subjected to a 9-week group intervention. Instruments: CBI, PTGI-X, PSS-10, HIV stigma, emotional expression, HIV stress indicators, HIV literacy, and skills. Multiple linear regression analysis was performed to assess the relationship between the variables. Results: There was an increase in PTG and a significant decrease in stigma in all domains and subscales in the EG. Compared to the control group, stigma (t(42) = −3.040, p = 0.004) and negative self-image (W = −2.937, p = 0.003) were significant, showing the efficacy of the intervention. Discussion: The intervention demonstrated success in facilitating PTG, attesting that in order to increase PTG, personal strength, and spiritual change, it is necessary to reduce stigma and negative self-image. The research provides more information on group interventions for PTG in HIV, relationships between variables, and population-specific knowledge for professionals.
Assessing the Knowledge of HPV-Associated Oropharyngeal Squamous Cell Carcinoma, HPV Vaccination, and Practice Scope among Saudi Dental Students in the Western Region
Authors: Alsharif Maha T. , Alsahafi Elham
Published: May 2024

(1) Background: Human papillomavirus (HPV) infection is significantly associated with oropharyngeal squamous cell carcinoma (HPV-OPSCC), which is one of the fastest-growing cancer incidences globally. Dental practitioners play a crucial role in the primary and secondary prevention of HPV-OPSCC. There is little known about dental students’ awareness regarding HPV-OPSCC and HPV vaccination, as well as their intention to promote ‘primordial prevention’ among their patients. HPV vaccine, and the extent of their professional responsibilities. (2) Methods: This cross-sectional study was conducted in the western region of Saudi Arabia and involved undergraduate dental students (n = 688) from six public and private dental schools. Participants were requested to complete a sequential-section anonymous online survey, with 257 successfully completing all sections of the questionnaire. The association between participant characteristics and HPV-OPSCC, HPV vaccination awareness ratings, and perceived engagement in prevention were analyzed using ANOVA and chi-squared testing. A binary logistic regression analysis was conducted to examine the variables linked to these outcomes. (3) Results: Generally, the overall level of awareness of HPV-OPSCC and HPV vaccination was acceptable, with an average score of 53.44 ± 29.3 out of 100. However, a significant knowledge gap was observed, with 53% of respondents being unaware of the common sites for HPV-OPSCC and 63.8% being uninformed of the appropriate age for HPV vaccination. Females and those with a prior history of sexually transmitted diseases (STDs) had considerably higher levels of HPV vaccination knowledge (p < 0.05). The participants showed a favorable attitude towards their responsibility of informing patients about HPV-OPSCC and advocating HPV immunization. (4) Conclusions: This study underscores the need to enhance dental students’ understanding of HPV-OPSCC and HPV immunization, enabling them to effectively engage in primary and secondary preventative efforts against HPV-OPSCC.
General, Vaccination, Navigational and Digital Health Literacy of Students Enrolled in Different Medical and Health Educational Programs
Authors: Kayupova Gaukhar , Takuadina Aliya , Bolatova Zhanerke , Dauletkaliyeva Zhaniya , Yerdessov Nurbek , Nukeshtayeva Karina , Zhamantayev Olzhas
Published: May 2024

Evaluating prospective graduates’ health literacy profiles before they enter the job market is crucial. Our research aimed to explore the health literacy levels of medical and health students by assessing their ability to obtain health-related information, understand healthcare systems, use e-health, and be informed about vaccination as well as to explore the factors associated with health literacy. Short versions of the HLS19-Q12 were used for a cross-sectional survey that was carried out among 1042 students enrolled in various medical and health educational programs at three medical universities in Kazakhstan between September and November of 2023. Additionally, instruments such as Digital Health Literacy (HLS19-DIGI), Navigational Health Literacy (HLS19-NAV), and Vaccination Health Literacy (HLS19-VAC) were employed. The score of General Health Literacy was 88.26 ± 17.5. One in eight students encountered difficulties in Vaccination Health Literacy. Despite overall high health literacy, Navigational Health Literacy posed challenges for all students. The Public Health students exhibited the highest General Health Literacy (91.53 ± 13.22), followed by students in Nursing, General Medicine, other educational programs (Dentistry and Biomedicine) and Pharmacy. Financial constraints for medication and medical examinations significantly influenced health literacy across all types of individuals. Since comprehensive health literacy instruction or interventions are still uncommon in the curricula, it seems reasonable to develop and incorporate appropriate courses for medical and health educational programs.
Implementing Trauma-Informed Care—Settings, Definitions, Interventions, Measures, and Implementation across Settings: A Scoping Review
Authors: Berring Lene Lauge , Holm Tine , Hansen Jens Peter , Delcomyn Christian Lie , Søndergaard Rikke , Hvidhjelm Jacob
Published: May 2024

Traumatic experiences can have long-lasting negative effects on individuals, organizations, and societies. If trauma is not addressed, it can create unsafe cultures with constant arousal, untrusting relationships, and the use of coercive measures. Trauma-informed care (TIC) can play a central role in mitigating these negative consequences, but it is unknown how and in which way(s) TIC should be implemented. Our objective was to conduct a scoping review that systematically explored and mapped research conducted in this area and to identify existing knowledge about the implementation of TIC. The search was conducted on the CINAHL, Cochrane, Embase, ERIC, Medline, PsycINFO, and Web of Science databases, and more than 3000 empirical papers, published between 2000 and 2022, were identified. Following further screening, we included 157 papers in our review, which were mainly from the USA, Australia, New Zealand, and Canada, focusing on study settings, methodologies, and definitions of TIC, as well as the types of interventions and measures used. This review shows that TIC is a complex and multifaceted framework, with no overarching structure or clear theoretical underpinnings that can guide practical implementations. TIC has been defined and adapted in varied ways across different settings and populations, making it difficult to synthesize knowledge. A higher level of agreement on how to operationalize and implement TIC in international research could be important in order to better examine its impact and broaden the approach.
Patient Knowledge, Medication Adherence, and Influencing Factors: A Cross-Sectional Study among Hypertensive Patients in Greece
Authors: Giakoumidakis Konstantinos , Patelarou Evridiki , Brokalaki Hero , Bastaki Maria , Fotos Nikolaos V. , Ifantopoulou Parthena , Christodoulakis Antonios , Chatziefstratiou Anastasia A. , Patelarou Athina
Published: May 2024

This study aimed to investigate the knowledge of patients with hypertension about their condition, adherence to antihypertensive medication, and the factors influencing it. A cross-sectional study was conducted in two cardiology outpatient clinics of two tertiary hospitals, in Greece. The study included 188 patients diagnosed with hypertension. The patients’ knowledge about their disease and adherence to medication were assessed by using the HK-LS and A-14 scales, respectively. Patients had sufficient knowledge levels about their disease, but significantly low levels of adherence to medication. Patients with higher knowledge levels were more adherent to medications [r(188) = 0.885, p < 0.001]. By using multivariate analysis, higher age (p = 0.018), residence in a more populous area (p = 0.041), more years with the disease (p = 0.012), and a lower number of medications (p = 0.03) were associated with higher levels of knowledge. Conversely, younger age (p = 0.036), lower educational levels (p = 0.048), fewer years with the disease (p = 0.001), and a higher number of medications (p = 0.003) were associated with lower adherence to medication. The Greek patients’ hypertension knowledge was sufficient; however, adherence to medication was significantly low. Healthcare managers could utilize our findings to design targeted interventions for improving adherence to medication for these patients.
Unveiling Anxiety Factors in Orthorexia Nervosa: A Qualitative Exploration of Fears and Coping Strategies
Authors: Tragantzopoulou Panagiota , Giannouli Vaitsa
Published: May 2024

Orthorexia nervosa represents a controversial phenomenon in the realm of eating practices, characterized by an obsessive fixation on consuming only foods deemed ’healthy’, and a preoccupation with food purity. While the existing literature has identified the presence of stressful behaviors among individuals with orthorexia, the precise factors and circumstances eliciting these stress-inducing emotions remain the subject of ongoing inquiry. This study aims to explore the triggers and situations that precipitate stressful beliefs and emotions among individuals who self-identify as preoccupied with healthy eating, as well as the coping mechanisms developed to manage these feelings. Through conducting one-to-one interviews with thirteen individuals, thematic analysis was employed to elucidate the nuances of their experiences. Participants articulated concerns regarding the contamination of foods available in supermarkets and restaurants, thereby prompting the meticulous selection of food sources and aversion to dining out. The prospect of trying new foods and engaging in social gatherings involving food emerged as anxiety-inducing scenarios, prompting individuals to adhere to monotonous dietary patterns and impose self-isolation. Additionally, medical appointments were perceived as stressful, driven by health concerns underpinning the adoption of stringent dietary practices. These findings underscore the spectrum of fears and coping mechanisms exhibited by individuals with orthorexia nervosa, which hold profound implications for their overall well-being.
Utilization of Health Care Services and Accessibility Challenges among Adults Aged 50+ before and after Austerity Measures across 27 European Countries: Secular Trends in the SHARE Study from 2004/05 to 2019/20
Authors: Borboudaki Lena , Linardakis Manolis , Tsiligianni Ioanna , Philalithis Anastas
Published: May 2024

This study aimed to assess and compare the utilization of preventive and other health services and the cost or availability in different regions of Europe, before and during the economic crisis. The data used in the study were obtained from Wave 8 of the Survey of Health, Ageing and Retirement in Europe (2019/2020) and Wave 1 data (2004/5), with a sample size of 46,106 individuals aged ≥50 across 27 countries, adjusted to represent a population of N = 180,886,962. Composite scores were derived for preventive health services utilization (PHSU), health care services utilization (HCSU), and lack of accessibility/availability in health care services (LAAHCS). Southern countries had lower utilization of preventive services and higher utilization of other health services compared to northern countries, with a significant lack of convergence. Moreover, the utilization of preventive health services decreased, whereas the utilization of secondary care services increased during the austerity period. Southern European countries had a significantly higher prevalence of lack of accessibility. An increase in the frequency of lack of accessibility/availability in health care services was observed from 2004/5 to 2019/20. In conclusion, our findings suggest that health inequalities increase during crisis periods. Therefore, policy interventions could prioritize accessibility and expand health coverage and prevention services.