bluuebunny/crossref_metadata_2025 huggingface dataset:
The performance and bearing capacity of bottom ashes filled embankment
Authors:   Hubei University of Technology, School of Civil Engineering and Architecture, Wuhan 430068, China., Ma Qiang , Chen Junfeng ,   Hubei University of Technology, School of Civil Engineering and Architecture, Wuhan 430068, China., Xiao Henglin ,   Hubei University of Technology, School of Civil Engineering and Architecture, Wuhan 430068, China., Zhong Chuheng ,   Hubei University of Technology, School of Civil Engineering and Architecture, Wuhan 430068, China., Chen Baoguo ,   China University of Geosciences(Wuhan), Engineering Faculty Wuhan 430074, China., Xu Qian ,   Hubei University of Technology, School of Civil Engineering and Architecture, Wuhan 430068, China.
Published: August 2022

The municipal solid waste incineration bottom ash (IBA) as the fill material in the geotechnical applications is a wise solution where IBA will save the bulk of earth material and can bring huge economic benefits, particularly for the embankments. In this study a series of experimental model tests of embankments filled with IBA and sand were conducted and considered two different slope ratios to investigate the performance of IBA as the fill material. During the testing, the vertical stress distribution, horizontal deformation, and vertical settlement inside of the embankment were monitored. Test results demonstrated that the IBA embankment compared with the sand embankment when slope ratios of 1:1.5 and 1:1.75, enhanced the bearing capacity by 25% and 20%, respectively, and under the same vertical pressure reduced the vertical settlement by 47% and 39.6%. When the embankment shear failure occurred, the lateral deformation inside the IBA embankment was reduced by 27.36% and 23.66%, respectively, compared with the sand embankment, under the conditions of slope ratio of 1:1.5 and 1:1.75, and the lateral deformation distribution along the height of embankment was more homogeneous. These results indicated that the use of IBA as fill material for embankments can be an economical and effective method to save the earth material.
The Effects of the TSOL Knot on the Repair Strength and Gliding Resistance Following Flexor Tendon Repair
Authors: Berry Charlotte E. , Mazzucchelli Lorenzo , Reisdorf Ramona L. , Moran Steven L. , Zhao Chunfeng
Published: August 2022

Background:

The stability of a suture knot construct has been realized as an important parameter that affects the strength of flexor tendon repairs. A novel 2-strand-overhand-locking (TSOL) knot, which is not commonly used in the clinical setting, recently was reported to increase repair strength and to decrease tendon gliding resistance in a 2-strand repair technique. The purpose of the present study was to investigate the effect of the TSOL knot on tendon repair strength and gliding resistance compared with a typical surgical knot in both 2-strand and 4-strand repair techniques using an in vitro turkey flexor tendon model.

Methods:

Sixty flexor digitorum profundus tendons from the long digit of the turkey foot were divided evenly into 4 groups and repaired with the following techniques: (1) a 2-strand modified Pennington repair with a square knot, (2) a 2-strand modified Pennington repair with a TSOL knot, (3) a 4-strand grasping cruciate repair with a square knot, and (4) a 4-strand grasping cruciate repair with a TSOL knot. Repaired tendons were tested for failure mode, gliding resistance, and repair strength at failure.

Results:

The repair strength and stiffness of the 4-strand repairs were significantly higher than those of the 2-strand repairs, regardless of knot type (p < 0.05). The repair strength at failure of the TSOL knot was significantly greater than that of the square knot in 2-strand repairs (p < 0.05) but not in 4-strand repairs. The gliding resistance of the TSOL knot was significantly decreased compared with that of the square knot in both 2-strand and 4-stand repairs (p < 0.05). With regard to failure mode, the TSOL knot was less likely to fail due to knot unravelling.

Conclusions:

In this in vitro biomechanical study involving the use of turkey flexor tendons to compare gliding resistance and repair strength characteristics for knot-inside 2 and 4-strand repairs, the TSOL knot was associated with decreased repaired tendon gliding resistance, regardless of the number of strands used. Although the TSOL knot also increased the repair strength, the difference was only significant when 2-strand repairs were used. The results of our study support the use of the TSOL knot in the clinical setting of flexor tendon repair using 2 or 4-strand, knot-inside methods.

Clinical Relevance:

In surgical repair of flexor tendons, there is substantial interest in maximizing strength while minimizing friction. This study shows the potential utility of the TSOL knot to increase repair strength while decreasing gliding resistance, particularly in 2-strand repairs.
Geçmişin Değeri Günün Sosyal Problemi: Yaşlılık ve Modern Toplumda Yaşlı Bakımı
Authors: ALTUNAY Zeynep , ÖZKUL Metin
Published: August 2022

Geleneksel yaşam biçiminde yaşlı, aile ve toplum içinde büyük bir değere sahipti. Tüm aile üyeleri yaşlıya saygı gösterir, ihtiyaçlarını karşılar ve hizmet ederdi. Günümüz çekirdek aile yapısında ise yaşlının özellikle sağlık sorunları, barınma ve bakım gibi temel ihtiyaçları gittikçe artan bir şekilde devlet kurumlarının desteği ile karşılanmaktadır. Yaşlının aile içindeki değeri ve statüsü de aile yapısının değişmesine bağlı olarak azalmıştır. Çünkü aile yapısının değişmesiyle birlikte günümüzde yaşlı ve çocuklar beraber ikamet etmemekte, kır kökenli genç kuşak ise kentsel alanda yaşamını sürdürürken bunların ebeveynleri olan yaşlıların çoğunluğu kırsal alanda yaşamaktadır. Kentsel ortamda kadın ve erkek öncelikle birlikte çalışma hayatına katıldığı için, ayrıca mekân farklılıkları, aile birlikteliğine yönelik değer anlayışındaki değişmeler vb. nedenlerin göreceli etkilerine bağlı olarak, ailenin genç üyeleri, bakıma ihtiyaç duyan yaşlısına yardımcı olamamakta ve yaşlılar gittikçe artan bir oranda devlet kurumlarından destek almaktadır. Eldeki çalışmada yaşlıların sorunları, değişen aile yapısı, bu değişme sürecine etki eden unsurlar ve toplumsal dönüşüm sonucunda yaşlıya yönelik değerlendirmelerin nasıl olduğu, yaşlı bakımında ailenin rolü ve desteği, ekonomik sistemlerin ve modern kurumsal yapıların yaşlılara yönelik hizmetleri, Zonguldak il merkezi ve mücavir alan sınırları içindeki kırsal nüfus içinden tabakalandırılmış örnekleme yoluyla seçilen yaşlılar üzerinde yapılan ampirik bir çalışmanın bulguları dikkate alınarak açıklanmaya çalışılmıştır.
Makine Öğrenmesi Algoritmaları ile Covid-19 Hastalarının Mortalite Risklerinin Hesaplanması
Authors: ÇAKMAK Mehmet Aziz , KURT Mehmet Emin , ÇAKMAK Cuma
Published: August 2022

Bu çalışmanın amacı, Makine Öğrenmesi algoritmalarıyla Covid-19 tanılı hastaların mortalite riskinin hesaplanmasıdır. Bu çalışmada, web üzerinde açık erişimli olarak yayınlanan Atlanta, Georgia’da Covid-19 tanısı alarak sağlık tesisine yatan hastaların demografik ve klinik verileri kullanılmıştır. Bu veriler üzerinden Karar Ağacı, Rastsal Orman ve Adaptive Boost olarak adlandırılan Makine Öğrenmesi algoritmaları kullanılarak hastaların mortalite riski hesaplanmıştır. Hastaların demografik ve klinik bulgularının mortalite riskleri üzerinde etkili olduğu ve bu doğrultuda oluşturulan Makine Öğrenmesi tabanlı tahmin modellemesinin yüksek güvenirlikle (Acc=83,5) uygulanabileceği görülmüştür. Elde edilen bulgularla birlikte Makine Öğrenmesi yöntemleri kullanılarak yüksek düzeyde güvenilir sınıflandırma modellemeleri oluşturulup hastaların mortalite risklerinin hesaplanması doğrultusunda klinisyenler ve sağlık profesyonellerine hasta önceliklendirme konusunda kılavuz olabilecek karar destek modülleri oluşturulabilmektedir. Web tabanlı modüller oluşturularak sağlık otoritelerine, klinisyenlere ve hastane yöneticilerine yatak doluluğu planlaması açısından etkin ve verimli hazırlık yapabilmeleri açısından bilimsel dayanak oluşturulmaktadır. Gereksiz sağlık harcamalarının ve hastalığı görece hafif geçirme ihtimali olan hastaların gereksiz tedavi almaları önlenebilecektir.
Multi-trait bayesian analysis and genetic parameter estimates in production characters of Mecheri sheep of India
Authors: K. Thiruvenkadan A. , Jaganathan Muralidharan , Ramanujam Rajendran , Chinnaondi Bandeswaran , Illa Satish Kumar , Kizilkaya Kadir , Peters Sunday O
Published: August 2022

The present study was conducted to calculate the genetic parameters for direct and maternal influences on Mecheri sheep growth features by Bayesian analysis using multi-trait animal model for designing suitable breeding application and genetic assessment methodologies. The genetic determinants for varying body weights at different ages were calculated using data from 2825 Mecheri lambs born between 2010 and 2020 that were kept in a warm and semi-arid climate. Mecheri sheep body weight (mean ± SE) at various stages viz., BW, WW and BW12 were 2.6 ± 0.01, 11.1 ± 0.05 and 20.7 ± 0.13 kg respectively. The direct estimates of heritability (± SD) for BW, WW, BW6 and BW12 were 0.21 ± 0.041, 0.21 ± 0.041, 0.12 ± 0.052 and 0.13 ± 0.053 respectively and the maternal heritability for BW, WW, BW6 and BW12 was 0.18 ± 0.021, 0.08 ± 0.023, 0.11 ± 0.022 and 0.13 ± 0.033, respectively. Estimates of maternal heritability suggests that even at later stages, there were considerable maternal effects. For several growth traits, positive estimates of additive genetic connections were observed, with values ranging from low to high. The additive genetic correlation between WW and BW6, BW9 and BW12 was 0.70 ± 0.145, 0.57 ± 0.171 and 0.50 ± 0.194. The maternal genetic correlations ranged from 0.06 ± 0.152 (BW-BW12) to 0.86 ± 0.046 (BW6-BW9) and the residual correlation increased progressively from 0.18 ± 0.034 (BW-WW) to 0.85 ± 0.013 (BW9-BW12). The medium to high estimates of heritability and genetic correlation of body weight parameters at various ages in Mecheri sheep indicated the genetic potential for all traits. In general, the features WW and BW6 both refer to the same genetic growth process, hence, it is recommended to undertake single trait selection based on weight at weaning age rather than using the present selection procedure of weight at six-month of age. By choosing the top performers from the Mecheri sheep flocks, it is possible to take advantage of the strong genetic potential for improvement in these parameters.
SARS-CoV-2 Genomic Contextual Data Harmonization: Recommendations from a Mixed Methods Analysis of COVID-19 Case Report Forms Across Canada
Authors: Cameron Rhiannon , Savić-Kallesøe Sarah , Griffiths Emma J. , Dooley Damion , Srid Aishwarya , Sehar Anoosha , Tindale Lauren C. , Hsiao William W.L.
Published: August 2022

Background
The timely sharing of public health information is critical during a pandemic and is an obstacle that Canada has yet to fully address. During the current Coronavirus Disease 2019 (COVID-19) pandemic, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) viral genome sequencing has provided a deeper understanding of transmission patterns, enabled the identification of variants of concern, and facilitated diagnostic tests and vaccine development and evaluation. The Canadian national response faces challenges in aggregating genomic contextual data and carrying out integrated analysis across regions partly due to disparities in the case report forms used to capture epidemiological and clinical data. Such variations delay data integration and make consistent analysis difficult or impossible. The objective of this work is to understand what information is being collected from severe acute respiratory syndrome coronavirus 2 case report forms used across Canada and identify potential genome sequence data harmonization issues and solutions.
Methods
Provincial/territorial/national Canadian COVID-19 case report forms were subjected to field-by-field comparisons to identify variations in data categorization, structures, formats, types, granularity, ambiguity, and questions asked. Federal epidemiologists were consulted to substantiate the results.
Results
Data harmonization issues and common data elements were identified. We make recommendations for better national coordination, integrated databases, and data harmonization tools.
Conclusion
This report compares data elements of the various case report forms used across Canada to identify overlaps and differences in the collection method of COVID-19 case information, while also highlighting data harmonization complications and potential solutions. Knowing which data elements are available to researchers and health officials will better inform the development of Coronavirus Disease 2019 surveillance and research questions.
Uplink SINR and Rate Analysis in Massive MIMO Systems with Two-Layer Linear Receiver
Authors: Abid Wahiba , Roy Sébastien , Ammari Mohamed Lassaad
Published: August 2022

In a previous work, a two-layer linear receiver was proposed as a low-complexity scheme that can achieve a good trade-off between performance and complexity in a massive multiple-input multiple-output (MIMO) context. For this scheme, the antenna array is split up into a number of subsets and multi-cell minimum mean-square-error (M-MMSE) combining is applied in each subset at the first layer. Then, the resulting outputs are combined using maximal-ratio combining (MRC) at the second layer. This paper presents a more complete performance analysis. First, we provide an entirely analytical derivation of the distribution of the output signal-to-noise-and-interference ratio (SINR) of first-layer processing based on multivariate statistical theory. The analysis includes both cases where the subset size is smaller or greater than the total number of signals. Furthermore, upper bounds and approximations on the average uplink SINR and achievable rate are derived. Numerical simulations confirm our analysis results.
A pilot study of several environmental endocrine disrupt ing chemicals in children with autism spectrum disorder in South China
Authors: Gao Chong-Jing , Yang Feng , Wu Bin-Bin , Liang Yan , Qin Yan-Yan , Guo Ying
Published: August 2022

Autism spectrum disorders (ASD) is a group of heterogeneous neurodevelopmental disorders. Evidences have implied that environmental pollutants are important factors related to ASD. In this study, several environmental endocrine disrupting chemicals (EDCs) including parabens, benzophenone-type ultraviolet (BP-type UV) filters, hydroxyl polycyclic aromatic hydrocarbons (OH-PAHs), triclosan (TCS) and tetrabromobisphenol A (TBBPA) were analyzed in blood plasma in ASD (n=34) and the control children (n=28). The results showed that parabens were the most concentrated chemicals (2.18 ng/mL, median value) in ASD children, followed by OH-PAHs (0.73 ng/mL), BP-type UV filters (0.14 ng/mL), TCS (0.13 ng/mL) and TBBPA (0.03 ng/mL). ASD children accumulated significantly lower 2-hydroxy-4-methoxybenzophenone (BP-3), 2,4-dihydroxybenzophenone (BP-1), 4-hydroxybenzophenone (4-HBP) and TCS, but higher 2-hydroxyphenanthrene (2-OH-Phen) and TBBPA than the control children (0.02/0.09 ng/mL of BP-3, p < 0.05; 0.04/0.07 ng/mL of BP-1, p < 0.05; 0.03/0.04 ng/mL of 4-HBP, p < 0.05; 0.13/1.22 ng/mL of TCS, p < 0.01; 0.03 ng/mL/not detected of 2-OH-Phen, p < 0.05; 0.03/0.004 ng/mL of TBBPA, p < 0.05). Sex-dependent differences in certain EDCs were evident, and the differences more inclined to boys. Positive associations between BP-3 and TCS, and TBBPA and 2-OH-Phen were found in ASD boys. Binary logistic regression analysis showed that the adjusted odds ratio (OR) value of 2-OH-Phen in ASD boys was 11.0 (1.45-84.0, p < 0.05). This is the first pilot study on multiple EDCs in children with ASD in China.
Deep Learning Infers Cell-dependent RNA Velocity through a Relay Velocity Model
Authors: wang guangyu
Published: August 2022

RNA velocity has provided a promising approach for inferring cellular state transition from single-cell RNA sequencing (scRNA-seq) data. Conventional RNA velocity models infer universal kinetics from all cells in a scRNA-seq experiment, resulting in unpredictable performance in the experiments with multi-stage and/or -lineage transition of cell states. Here, we present cellDancer, a scalable Deep Neural Network (DNN) framework, to locally infer velocity for each cell from its neighbors on gene space and then relay cell-dependent velocities of all cells. We showed that cellDancer is efficient to overcome the fundamental limitation of existing RNA velocity models in multi-stage transition during gastrulation erythroid maturation and the multi-lineage differentiation in hippocampus development. Moreover, cellDancer provides the cell-specific prediction of transcription, splicing, and degradation rates which illuminates mechanisms of transcriptome regulation.
Effect of Simultaneous High-definition Transcranial Direct Current Stimulation and Robot-assisted Gait Training on Gait Function in Chronic Stroke Patients
Authors: Kim Eunmi , Lee Jungsoo , Lee Gihyoun , Kim Yun-Hee
Published: August 2022

Background
Robot-assisted gait training (RAGT) is used for rehabilitation after stroke, but not all chronic stroke patients achieve satisfactory improvement in physical ability. The purpose of this study was to investigate whether the effects of RAGT on gait and physical function in chronic stroke patients could be enhanced by simultaneously applying high-definition transcranial direct current stimulation (HD-tDCS).
Methods
Twenty-four chronic hemiplegic stroke patients (15 males; mean age 60.5 ± 13.9 years) participated in this study. The subjects were randomly allocated to either the RAGT with real HD-tDCS group (RAGT \(\stackrel{-}{\text{c}}\) rHD-tDCS) or the RAGT with sham HD-tDCS group (RAGT \(\stackrel{-}{\text{c}}\) sHD-tDCS). Each group completed 10 sessions over four consecutive weeks. Gait and physical function were measured by the 10 Meter Walk Test (10MWT), Timed Up and Go (TUG), Functional Ambulation Category (FAC), Functional Reach Test (FRT), Berg Balance Scale (BBS), Dynamic Gait Index (DGI), Fugl-Meyer Assessment (FMA), and the Korean version of the Modified Barthel Index (K-MBI). Assessments were performed before intervention (Pre), immediately after intervention (Post), and at follow-up (F/U) one month after the intervention.
Results
The RAGT \(\stackrel{-}{\text{c}}\) rHD-tDCS group showed statistically significant improvements in 10MWT, TUG, FRT, and BBS at Post and F/U compared to Pre (P < 0.05). The RAGT \(\stackrel{-}{\text{c}}\) rHD-tDCS group also improved significantly in the DGI and FMA at Post compared with Pre (P < 0.05). The RAGT \(\stackrel{-}{\text{c}}\) sHD-tDCS did not show significant improvement at Post or F/U compared to Pre. Repeated measures analysis of variance revealed significant time × group interactions in the FMA and the K-MBI (P < 0.05), indicating that the RAGT \(\stackrel{-}{\text{c}}\) rHD-tDCS group experienced greater improvements in motor and activities of daily living functions compared with the RAGT \(\stackrel{-}{\text{c}}\) sHD-tDCS group.
Conclusion
These results demonstrate that simultaneous application of HD-tDCS during RAGT produces positive effects on gait and physical function in chronic stroke patients. Combining RAGT with HD-tDCS ensured long-term training effects for up to one month. HD-tDCS can be suggested as a complementary tool for enhancing robotic gait rehabilitation therapy in chronic stroke patients after a larger confirmatory study to verify these effects.
Trial registration:
Clinical trials registration information: ClinicalTrials.gov Identifier: NCT04985864 (07/30/2021).
Photocatalytic degradation of Congo red, Crystal violet and Textile Industrial effluent using cuprous oxide nanoparticles synthesized using root extract of Withania somnifera
Authors: Dhara Manmata , Karmakar Aditi , Kisku Kanika , Ganesan Senthil Kumar
Published: August 2022

The photocatalytic activity of biofunctionalized yellow cuprous oxide nanoparticles (Cu2O NPs) for the breakdown of Congo red, Crystal violet and textile industrial effluent is being investigated in this research. We used root extract of Withania somnifera to synthesise Cu2O NPs, which resulted in spherical, monodispersed Cu2O NPs with an average diameter of 410 nm. In the presence of a reducing agent sodium borohydrate and Cu2O NPs, we performed photocatalytic degradation of Congo red and Crystal violet. After treatment with both sodium borohydrate and Cu2O NPs, UV-Visible Spectrophotometry revealed that 66.15 percent Congo red and 66.58 percent Crystal violet were degraded, respectively. The treatment of industrial effluent with Cu2O NPs showed production of degradation by-products and significant removal of toxic heavy metals as evident from the Gas Chromatography-Mass Spectrometry (GC-MS) and Inductively coupled plasma-optical emission spectrometry (ICP-OES) analysis respectively. Industrial effluent treated with Cu2O NPs had shown to have significantly less detrimental effect on HEK cell lines as evident from the MTT assay.
Luminescent Transparent Wood from Balsa wood (Ochroma pyramidale) Loaded by Graphite Carbon Nitride for Implication of Photoelectric Device
Authors: Yin Xuefeng , Zhang Yaqian , Xu Yongjian
Published: August 2022

In this study, metal-free wood-based encapsulating materials for WLED was obtained by using renewable transparent wood as the biological support and the light scattering component, and graphite carbon nitride as the color light emitting component. The graphite phase carbon nitrides with blue and green color were prepared by thermal polymerization through structural regulation of raw materials. The resulting different color phosphors were mixed with epoxy resin, respectively, and then blue epoxy resin, green epoxy resin and red epoxy resin were mixed with a mass ratio of 4:2:1 and adding a proper amount of curing agent. The delignified balsa wood with high porosity was vacuum impregnated with epoxy resin mixture to obtain white luminescent transparent wood (g-C3N4 (W)@TW) with better performance such as high transmittance and high haze. It provides a feasible solution for the sustainable development of transparent wood and the application of transparent wood to photoelectric materials.
Evaluation and validation of the increased annexin A3 (ANXA3) as a novel biomarker to predict sepsis in critically ill patients
Authors: Lu Hong-xiang , Ma Cong-cong , Wen Da-lin , Chen Guo-sheng , Zhang Fei , Xu Gang , Shi Qing-hai , Zhang An-qiang
Published: August 2022

Background:Current research indicated Annexin A3 (ANXA3) was involved in innate immunity. Nevertheless, the comprehensive expression of ANXA3 in sepsis patients remain uncertain.Methods:We performed a meta-analysis utilizing public datasets form Array Express and Gene Expression Omnibus (GEO) to summarize and evaluate the expression level of ANXA3 in sepsis patients. Then, we investigated the associations between plasma ANXA3 and sepsis via a retrospective study. The predictive ability of plasma ANXA3 for sepsis was evaluated using the Area Under the Curve (AUC).Results:Totally, the meta-analysis including 2612 sepsis and 2259 controls indicated sepsis patients were with markedly higher levels of ANXA3 mRNA expression (SMD=2.04 (1.54-2.55); p<0.00001). Meanwhile, sepsis deaths (n=500) were with limited higher expression of ANXA3 mRNA than sepsis survivors (n=1711) (SMD=0.11(0.01-0.22); p=0.03). Furthermore, our results indicated plasma ANXA3 on admission were significantly associated with the incidence of sepsis in critically ill patients (OR=2.41(1.75-3.32), p<0.001). As a predictive biomarker, plasma ANXA3 resulted in a better AUC 0.815(0.745-0.886) than procalcitonin (PCT) (0.673(0.584-0.761)) and interleukin-6 (IL-6) (0.672(0.585-0.759)) and SOFA score (0.668(0.577-0.759)). Additionally, patients with high plasma ANXA3 had a poorer overall 28-day survival in critically ill patients (HR=2.16(1.09-4.28); p=0.028), but not for sepsis patients (HR=1.63(0.65-4.06); p=0.276).Conclusions:This study evaluated and validated ANXA3 was increased in sepsis. As a predictive biomarker, plasma ANXA3 obtained a good predictive ability for sepsis. Meanwhile, plasma ANXA3 was associated with outcomes of critically ill patients, but not sepsis patients.
Assembling High-Quality Lymph Node Clinical Target Volumes for Cervical Cancer Radiotherapy Using a Deep Learning-Based Approach
Authors: Jiang Xiaoxuan , Zhang# Shengyuan , Fu Yuchuan , Yu Hang , Tang Huanan , Wu Xiangyang
Published: August 2022

Background: To explore an approach for accurate assembling high-quality lymph node clinical target volumes (CTV) on CT images in cervical cancer radiotherapy with the encoder-decoder 3D network. Methods: CT images from 216 cases were involved from 2017-2020 in our center. 216 patients were divided into two cohorts, including 152 cases and 64 cases respectively. The first cohort with 152 cases whose para-aortic lymph node, common iliac, external iliac, internal iliac, obturator, presacral and groin nodal regions as sub-CTV were delineated manually. Then the 152 cases were randomly divided into training ( n=96 ), validation ( n=36 ) and test ( n=20 ) groups for training process. Each structure was individually trained and optimized through a deep learning model. An additional 64 cases with 6 different clinical conditions were taken as examples to verify the feasibility of CTV generation based on our model. Dice similarity coefficient(DSC) and hausdurff distance(HD) metrics were both used for quantitative evaluation.Results: Comparing auto-segmentation results to ground truth, the mean DSC value/HD were 0.838/7.7mm, 0.853/4.7mm, 0.855/4.7mm, 0.844/4.7mm, 0.784/5.2mm, 0.826/4.8mm and 0.874/4.8mm for CTV_PAN, CTV_common iliac, CTV_internal iliac, CTV_external iliac, CTV_obturator, CTV_presacral and CTV_groin, respectively. The similarity comparison results of 6 different clinical situations were 0.877/4.4mm, 0.879/4.6mm, 0.881/4.2mm, 0.882/4.3mm, 0.872/6.0mm and 0.875/4.9mm for DSC value/ HD respectively.Conclusions: We developed a deep learning-based approach to segmenting lymph node sub-regions automatically and assembling CTVs according to clinical needs with these sub-regions in cervical cancer radiotherapy. This work can be applied to improve the consistency and flexibility of high-quality CTV delineation, increase the efficiency of cervical cancer work process.
C-MEMS Derived Glassy Carbon Electrochemical Biosensors for Rapid Detection of SARS-CoV-2 Spike Protein
Authors: Pramanick Bidhan , Mandal Naresh , Mitra Raja
Published: August 2022

According to the World Health Organization (WHO) report, the world has experienced more than 568 million positive cases and more than 6 million deaths due to COVID infection. WHO declared a pandemic due to the rapid spread of the SARS-CoV-2 virus, and the fight against this pandemic is not over yet. The significant reasons for virus spread are the lack of detection kits, appropriate detection techniques, delay in detection, asymptomatic cases and failure in mass screening. In the last two years, several researchers and medical companies have introduced successful test kits to detect the infection of symptomatic patients in real-time, and it was needed to monitor the spreading. But it is equally important to have information on the asymptomatic cases, which can be done by antibody testing for the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus.
We have developed a simple, advantageous immobilization procedure for rapidly detecting SARS-CoV-2 spike protein in this work. Carbon-MEMS-derived glassy carbon (GC) is used as the sensor electrode, and the detection is based on covalently linking the SARS-CoV-2 antibody to the GC surface. Glutaraldehyde was a cross-linker between antibody and glassy carbon electrode (GCE). The binding was investigated using Fourier Transform Infrared Spectroscopy (FTIR) characterization and cyclic voltammetric (CV) analysis. Electrochemical impedance spectroscopy was utilized to measure the change in total impedance before and after incubation of the SARS-CoV-2 antibody with various concentrations of SARS-CoV-2 spike protein. It is observed that the developed sensor can sense 1 fg/ml to 1 µg/ml concentration of SARS-CoV-2 spike protein. This detection is label-free, and the chances of false alarm are almost nil. The developed sensor can be used for mass screening as it is cost-effective.
Analysis of concentration of trace elements in blood of Polish patients with prostate cancer
Authors: Drozdz-Afelt Joanna Maria , Koim-Puchowska Beata , Kaminski Piotr
Published: August 2022

Aims: The goal of the study was to analyse the concentrations of chemical elements (Fe, Ni, As, Cd, Pb, Hg, Cr, Zn) which are important for the determination of environmental toxins (e.g. resulting from smoking, exposure to harmful agents at work) in Polish patients with prostate cancer.Methods: The study covered 66 patients with diagnosed prostate cancer and 64 healthy volunteers over 50 years old. The analysis of the concentrations of selected chemical elements in whole blood was performed using inductively coupled plasma mass spectrometry (ICP-MS).Results: In their blood, the patients with cancer had a significantly higher concentration of only one of the examined elements: arsenic. Additionally, the study group had lower concentrations of chromium, zinc, but also cadmium and lead, which are commonly regarded as carcinogenic.Conclusion: Taking into consideration the control group of healthy subjects of this study, we can assume that the subjects with prostate cancer were exposed to higher levels of arsenic, and that exposure to this element may be associated with an increased risk of cancer.
ASIAN COLLECTING IN CHILE: THE CONDITION OF ITS OBJECT OF STUDY AND ITS RELATIONSHIP WITH THE MUSEUM
Authors:   Faculty of Liberal Arts, University Adolfo Ibáñez, Diagonal Las Torres 2640, Peñalolén, Santiago, Chile, Maire Gonzalo
Published: August 2022

This article focuses on the study of the terms “collecting” or “collection”— particularly of the Asian type—in Chile, through the lens of the following working thesis: the term “collecting”, which involves both an acquisition practice and a particular relationship with its elements, has been fundamentally studied as an extension of, or in dependence to, the domain of the museum. This cardinal tenet involves, on the one hand, the decidability adopted by the phenomenon of collecting that is determined by its power to be registered or interpreted based on the enunciative dynamics of the museum field; on the other hand, I shall argue that this stems from its failure to constitute itself as an object which can exist outside the museum’s jurisdiction. Regarding this dependence or analogy of Asian Collecting on the area of influence of the museum, this investigation will describe the rules of formation which inform said dependence. By rules of formation, I shall refer to the possibility of a “language”, or special enunciation, dominion of the Museum over its objects, articulations, and its reproducible and verifiable scope areas. Specifically, two laws of museality will be developed in the present article, the museum’s heterotopia and the taxonomy of what is real. The Museum’s domain shall constitute, or rather, express, the positivity which is englobed in the concept of museality in reference to Michel Foucault’s definition. As such, this article focuses on the description of norms and rules which make up museality, and the manner in which Asian Collecting is subsumed to and made visible by the concept. For this article, catalogues of Asian collections—once belonging to private Chilean collectors—available in Chile will be used.
STUDY OF THE IMPACT OF LABELS ON THE COMMERCIAL PERFORMANCE OF COOPERATIVES CASE OF A COOPERATIVE IN THE ESSAOUIRA, MOROCCO
Authors:   Research Scholar, Research Laboratory in Entrepreneurship, Finance and Audit (LAREFA), National School of Commerce and Management, IbnZohr Agadir University, Morocco., El Farri S. , El Meskine L. ,   Professor, Research Laboratory in Entrepreneurship, Finance and Audit (LAREFA), National School of Commerce and Management, IbnZohr Agadir University, Morocco., Oubdi L. ,   Professor, Director of the Research Laboratory in Entrepreneurship, Finance and Audit (LAREFA), National School of Commerce and Management, IbnZohr Agadir University, Morocco.
Published: August 2022

The main objective of each entity is the achievement of profit, so the manager has to look for the best solutions and actions to achieve better performance. Cooperatives, like any organization, are no exception to this rule. Faced with the many problems they face in terms of marketing their products, they need to adopt innovative approaches, particularly the labeling of their products. In the framework of our research, we have focused on the role of labels in the commercial performance of cooperatives, based on data collected from our survey with these social entities.
ORAL RECONSTITUTABLE HERBAL DRY SYRUP: FORMULATION, DEVELOPMENT AND ASSESSMENT
Authors:   Student, Kailash Institute Of Pharmacy & Management, Gida, Gorakhpur., Gupta Anukriti , Mishra J.N. ,   Faculty, Kailash Institute Of Pharmacy & Management, Gida, Gorakhpur., Vishwakarma D.K. ,   Faculty, Kailash Institute Of Pharmacy & Management, Gida, Gorakhpur., Pandey Chitranshu ,   MRD Life Sciences Pvt. Ltd., Lucknow.
Published: August 2022

The ease of administration, patient comfort, and formulation stability are all advantages of the oral dose form. Tablets and capsules are the most popular oral dosage forms nevertheless, one notable disadvantage of these solid dosage form is the trouble in ingesting them, especially when a supplement is designated for children or the elderly. The disease TB(Mycobacteriae) had antibiotics and one of those is levofloxacin that is used in the cure this Mycobacteria. Levofloxacin is a broad-spectrum antibiotic that develop Multi Drug Resistance (MDR) in our body. So, in order to modify this treatment of MDR, herbal drugs are implemented in the drug for better working of the antibiotic. Herbal medications, whether extract or decoction, will not induce drug resistance when administered against any infection. Hence an effective ad appropriate drug therapy as an anti â€“ tuberculosis drug needs to be discovered which will solve the problem of cross resistance and drug resistanceThe goal of this research was to build and create an oral Reconstitutable Herbal Dry Syrup that can be readily dispersed in a potable water medium before usage and is chemically and microbiologically stable throughout consumption. This herbal drug is anti-infective, anti-hepatotoxic and anti-inflammatory, cholagogue etc.There was no discernible difference in particle size, fluidity, pH, or drug content after 15 days of testing. After employing Reconstitutable water with levofloxacin herbal dry syrup, the stability was effectively evaluated.
A REVIEW ON CLOUD LOAD BALANCING TECHNIQUES
Authors:   Department of Information Technology, Netaji Subhash Engineering College, Kolkata, India., Das Sayantan , Mondal Madhurima ,   Department of Information Technology, Netaji Subhash Engineering College, Kolkata, India., Swarnakar Soumen ,   Department of Information Technology, Netaji Subhash Engineering College, Kolkata, India.
Published: August 2022

Cloud computing simply means storing & accessing data and programs over the internet instead of your computers hard drive. The cloud is just a metaphor for the internet. An example of Cloud Computings process could also be Googles Gmail. Cloud computing is highly efficient, productive, safe & secure. Cloud computing consists of two terms One is Cloud which is a useful feature of computer technology to perform appropriate tasks. Computing may include computer hardware and software but must involve some form of a computer system. It is a type of operation of a computer that is fully dependent on exchanging computing resources rather than having local servers or personal devices to handle the appeal. Cloud refers to a public or semi-public space on transmission lines that exists between the endpoints of a transmission. Data that is transmitted across a WAN enters the network from one endpoint using a standard protocol.
El cuerpo en la dimensión trágica de la ética psicoanalítica: filosofía y psicoanálisis
Authors:   Universidad Católica Luis Amigó, Jaramillo Zapata Jorge Iván
Published: August 2022

La experiencia de un análisis parte del hecho de que el síntoma se presenta como algo en el cuerpo que demanda una interpretación. Allí es inevitable desembocar en un juicio sobre lo más íntimo que habita en cada uno de nosotros; el develamiento de aquello que la consciencia habría preferido rechazar. Es en este punto donde el cuerpo, la ética y la tragedia coinciden. Se trata, entonces de un recorrido que parte de la pregunta sobre los puntos de encuentro y desencuentro entre la filosofía y el psicoanálisis respecto a la ética, la tragedia y el cuerpo como tercero que anuda dicha reflexión. Se plantea la relación entre autores como Aristóteles, Nietzsche, Freud y Lacan para llegar a lo específico de la elaboración teórica del psicoanálisis, encontrando allí el cuerpo como un efecto de lenguaje y, por ende, con una estructura marcado por lo inefable que es causa del síntoma.
RESEARCH OF THE ASYMPTOTIC EQUILIBRIUM OF TIME-DELAY SYSTEMS BY JUNCTION OF LYAPUNOV - KRASOVSKII AND RAZUMIKHIN APPROACHES
Authors:   St. Petersburg State University, KUPTSOVA SVETLANA E. , KUPTSOV SERGEY YU. ,   OOO "OGS Russia"
Published: August 2022

The nonlinear time-delay systems are considered and the limiting Behavior of their solutions is investigated. The case in which the solutions have a trivial equilibrium that may not be an invariant set of the system is studied. The junction of Lyapunov - Krasovskii and Razumikhin approaches is applied to obtain sufficient conditions for the existence of an asymptotic quiescent position in the large. In the case when a general system has a trivial solution, new sufficient conditions for its asymptotic stability are obtained. Examples, that illustrate the application of the obtained results, are given.
ANALYSIS OF SIMPLIFIED GAS TRANSPORTATION MODELS. CALCULATION OF THE GAS LEAK LOCATION IN A PIPELINE
Authors:   St. Petersburg State University, KURBATOVA GALINA I. , VINOGRADOVA EKATERINA M. ,   St. Petersburg State University, KLEMESHEV VLADIMIR A. ,   St. Petersburg State University
Published: August 2022

An approach to a simplified calculation of the characteristics of a steady gas flow through a pipeline is proposed. In this approach, the pressure is calculated using an isothermal model; the temperature analysis is reduced to a cubic equation solving. A simple analytical gas leak point coordinate dependence on the pressure and gas flow values is obtained at outlet from the pipeline. The result of comparison of calculations for the general and simplified models of gas flow in pipelines is presented. A criterion has been determined for the fulfillment of which it is permissible to use a simplified approach to calculating the gas characteristics and the leak point coordinates. Using an example of practical interest, the high accuracy of the calculation according to the proposed approach of both pressure and temperature in the flow and the gas leak coordinate in the pipeline is demonstrated.
ONTOLOGICAL APPROACH APPLICATION TO THE DESIGN OF A GEOSPATIAL EXPERIMENTAL DATABASE FOR INFORMATION SUPPORT OF RESEARCH IN PRECISION AGRICULTURE
Authors:   Agrophysical Research Institute, MITROFANOVA OLGA A. ,   St. Petersburg State University, MITROFANOV EUGENII P. ,   Agrophysical Research Institute,   St. Petersburg State University, BURE NATALIYA A. ,   Agrophysical Research Institute
Published: August 2022

Thanks to the development of information technologies and computing resources, it became possible to obtain and process big data, including geospatial data. Most research in the field of precision farming is interdisciplinary in nature, with experimental field data used by disparate scientific groups. In this connection, it became necessary to develop a unified web-based system for storing, organizing, and exchanging experimental information between researchers. The first step in achieving this goal was to create a geospatial database. Since the system being developed in the future may require extensions, modifications, adjustments, integration into other projects, it seems appropriate to use the ontology to form the database structure. The most popular tools were used as the main tools: the ontology language OWL (Ontology Web Language), the Protege 5.5 development environment. The main initial information obtained in the course of experimental studies carried out at the biopolygon: weather data, agrochemical indicators (sampling of soil and plants with georeferencing), agrophysical parameters (humidity, electrical conductivity), remote sensing data. Based on the results of the analysis of the current state of research in the field of storage and systematization of experimental information in crop production, as well as a survey of ARI employees, a prototype of the database structure was formed based on the ontological approach. Nine parent classes were defined as the foundation: Field, Crop rotation - experience, Agrotechnology, Yield, Meteo, Ground samples, Orthophoto, Calendar, and Dictionary - units of measurement.
Programa de integración en contexto de encierro: Dificultades y propuestas para un mejor abordaje de los procesos de trabajo
Authors:   Universidad Metropolitana de Ciencias de la Educación, Guerrero Rivera Belén , Mora Troncoso Carolina ,   Universidad Metropolitana de Ciencias de la Educación, Zavala Aránguiz Constanza ,   Universidad Mayor
Published: August 2022

Sensibilizar y dar a conocer la realidad educativa que existe al interior de los centros penales, permite generar conciencia de la transcendencia que tiene la educación en la sociedad, como herramienta de cambio y resiliencia en personas que necesitan y/o aspiran a la inserción o reinserción social. Dentro de este ámbito, cobra relevancia el concepto de inclusión, el cual, en la mayor parte de las escuelas, son los Programas de Integración Escolar (PIE) los encargados de promover, facilitando estrategias y herramientas que ayuden a los estudiantes a superar sus barreras de aprendizaje. El presente artículo tiene como objetivo dar a conocer las dificultades a las que se ven expuestas las profesionales del Programa de Integración Escolar (PIE) de la escuela Hugo Morales Bizama, ubicada al interior del Centro Penitenciario Femenino Marisol Estay, en la comuna de San Miguel, al momento de implementar y desarrollar las exigencias ministeriales, las cuales no están contextualizados a este espacio educativo. Desde lo anterior, es que el actual documento realiza una propuesta e invita a la reflexión en torno a las mejoras que se requieren en términos legales y de estructura en los programas de integración insertos en contextos de encierro, para desarrollar un trabajo más óptimo y de mayor impacto.
Proteomic Analysis of Glucose-Induced Cardiac Myoblasts and the
Potential Role of mir-92b-5p in Regulating Sarcomere Proteins Under a
Hyperglycemic Environment
Authors: Mathur Priyanka , Rani Vibha
Published: August 2022

Background:

Diabetes mellitus, a common metabolic disorder that causes high blood
glucose, is due to impaired insulin secretion. Prolonged high blood sugar is associated with heart
disease. Many proteins are involved in metabolic pathways and contractility of cardiac cells regulate
cardiac hypertrophy, altering normal cardiac physiology and function. Moreover, microRNAs are
essential regulators of these proteins. Thus, there is a need to study the protein and microRNA
alterations in cardiomyocytes to better understand the mechanisms activated during cardiac stress.

Objective:

The study aims to profile differentially expressed sarcomere proteins in H9C2 cell lines
under high glucose conditions compared with normal conditions, along with the identification of
miRNAs regulating these proteins.

Methods:

Cardiac myoblast cell lines were treated with D-Glucose at three concentrations (10 mM,
25 mM, and 50 mM). Total cell protein was analyzed by Tandem Mass spectrometry Nano LCMS/
MS. Furthermore, next-generation sequencing data were analyzed for detecting microRNAs
regulating cardiac cell protein expression. Bioinformatics databases such as Uniprot, Ingenuity
Pathway Analysis (IPA), PANTHER, and Target scan were used.

Results:

The Nano LC-MS/MS analysis showed 2891 protein, 1351 protein groups, and 4381
peptide groups in both glucose-treated and control samples. Most proteins were metabolite
interconversion enzymes, translation proteins, and proteins regulating the cytoskeleton. IPA
analysis revealed differentially expressed proteins involved in EIF2 signaling, actin cytoskeleton
signaling, cardiac fibrosis, and cell death. Moreover, the proteins troponin, tropomyosin, myosin,
alpha-actin, and ATP synthase were found to be downregulated, thus responsible for altering
sarcomere protein expression. Rno-mir-92b-5p was observed to be highly upregulated at 50 mM.
Its target genes namely TPM2, ATP1A2, and CORO1C were mostly components of the sarcomere
complex and its regulators.

Conclusion:

A combination of proteomic profile and microRNA profile of hyperglycemic cells
provides an insight into advanced therapeutics. Our study has highlighted the role of sarcomere
proteins, activation of Eukaryotic Initiation Factor 2 (EIF2) signaling, and suppression of actin
cytoskeleton signaling in the pathophysiology of cardiomyopathy. MiR-92b-5p has an important
role in regulating sarcomere protein complex activated.
Corrigendum to: Diversity and Functionality of Mycobacterial Mycolic Acids in Relation to Host-pathogen Interactions
Authors: Druszczyńska Magdalena , Kowalski Konrad , Wawrocki Sebastian , Fol Marek
Published: August 2022

The author requested to revise the acknowledgements section of the following article [1]. In this correction, the
acknowledgements have been revised in the article entitled “Diversity and Functionality of Mycobacterial Mycolic
Acids in Relation to Host-pathogen Interactions” in the journal Current Medicinal Chemistry, 2017, 24(38),
4267-4278.

Details of corrections are provided here.

The original article can be found online at http://dx.doi.org/10.2174/0929867324666170823130445

We regret any errors and apologize to the readers.

Original

ACKNOWLEDGEMENTS

This work was supported by National Science Centre (Poland) under grant no. 2016/21/B/NZ7/01771 and
2013/11/B/NZ6/01304.

Corrected

ACKNOWLEDGEMENTS

This work was supported by National Science Centre (Poland) under grant no. 2013/11/B/NZ6/01304.