bluuebunny/crossref_metadata_2025 huggingface dataset:
PRODUKSI HIJAUAN SORGUM SORGHUM BICOLOR (L.) MOENCH PADA BERBAGAI KONSENTRASI PUPUK ORGANIK CAIR DAN BERBAGAI UMUR POTONG
Authors: Agung Kurnia  , Hidayat  , Puji Harsono Rizky Saputra  , Rinjjitha Handayani
Published: January 2025

Penelitian ini bertujuan untuk mengkaji pertumbuhan dan hasil hijauan sorgum pada beberapa konsentrasi pupuk organik cair dan beberapa umur potong. Penelitian dilaksanakan selama 75 hari. bertempat di kelurahan kandang mas, Kota Bengkulu.Faktor pertama berupa konsentrasi pupuk organik cair (POC), terdiri dari 4 taraf yakni K1 (200 ml + 10 liter air), K2 (400 ml + 10 liter air), K3 (600 ml +10 liter air) dan K0 sebagai kontrol. Faktor kedua adalah umur potong yaitu; 45 hari setelah tanam (hst)/U1, 60 (hst)/U2, dan 75 (hst)/U3. Parameter yang diamati adalah pertumbuhan tinggi tanaman,jumlah daun,dan diameter batang 21 dan 42 hari setelah tanam (hst). Hasil penelitian menunjukkan bahwa Pemberian pupuk organik cair konsentrasi 200 ml + 10 l air pada tanaman mampu memperbesar diameter batang sorgum sebesar 14% lebih tinggi dari  tanpa pemberian POC. Pupuk organik cair konsentrasi 600 ml + 10 l air yang diberikan pada tanaman sorgum terbukti meningkatkan produksi bahan kering sorgum (ton/ha/tahun/panen ) sebesar 43,11% lebih tinggi dari sorgum yang tidak diberi POC. Tanaman sorgum dipotong pada umur 60 hst menghasilkan produksi bahan kering tertinggi yakni 129,57%  lebih tinggi dari umur potong 45 hst dan 10,88% lebih tinggi dari umur potong 75 hst. Tidak terjadi pengaruh interaksi  antara pemberian POC dengan umur potong tanaman sorgum.
PRODUKSI DALAM TAFSIR AL-QUR’AN
Authors: Hasan Husaini  , Badruddin
Published: January 2025

Produksi dalam Islam memiliki dimensi spiritual, etis, dan sosial yang menjadi pembeda utama dari konsep produksi konvensional yang berorientasi pada keuntungan semata. Penelitian ini bertujuan untuk menggali konsep produksi berdasarkan nilai-nilai Al-Qur'an. Dengan pendekatan kualitatif, penelitian ini menggunakan metode studi literatur untuk menganalisis ayat-ayat Q.S. Al-Hadid: 25, Al-Anbiya: 80, dan Saba’: 10-11. Ayat-ayat tersebut memberikan landasan penting tentang nilai-nilai produksi, termasuk keadilan, keberlanjutan, dan kemaslahatan. Produksi dalam Islam dipahami sebagai bagian dari ibadah, di mana setiap aktivitas produksi harus dilakukan dengan niat yang benar, mematuhi syariat, dan bertujuan untuk membawa manfaat bagi manusia serta lingkungan. Penelitian ini menemukan bahwa Al-Qur'an menekankan pentingnya peran manusia sebagai khalifah yang bertanggung jawab terhadap pengelolaan sumber daya, memanfaatkan teknologi secara bijak, dan berorientasi pada kesejahteraan umat. Hasil penelitian menunjukkan bahwa produksi tidak hanya berfungsi untuk memenuhi kebutuhan material, tetapi juga sebagai sarana mensyukuri nikmat Allah dan mendekatkan diri kepada-Nya. Dengan demikian, konsep produksi dalam Islam tidak hanya memprioritaskan aspek ekonomi, tetapi juga membangun keselarasan antara tujuan spiritual, sosial, dan lingkungan, yang relevan dalam mewujudkan keadilan dan keberlanjutan kehidupan.
BERBAGAI BENTUK DALAM JUAL BELI: BA’I AL-WAFA, BA’I AL-INAH, BA’I BITSAMAN ‘AJIL, DAN BA’I TAWARRUQ
Authors: Badruddin  , Hasan Husaini
Published: January 2025

Bai’ al-Wafa, Bai’ al-‘Inah, Bai’ Tawarruq, dan Bai’ Bitsaman Ajil adalah empat jenis akad dalam fiqh muamalah yang digunakan dalam transaksi jual beli. Penelitian ini bertujuan untuk menjelaskan konsep, hukum, dan penerapan dari masing-masing akad tersebut dalam praktik ekonomi syariah. Metode yang digunakan adalah studi literatur dengan mengkaji berbagai pendapat ulama dari berbagai madzhab dan pandangan kontemporer tentang keempat akad tersebut. Bai’ al-Wafa’ adalah jual beli dengan syarat bahwa barang yang dijual dapat dibeli kembali oleh penjual pada waktu yang telah disepakati. Bai’ al-‘Inah melibatkan transaksi jual beli di mana barang dijual secara tunai kemudian dibeli kembali dengan harga lebih tinggi secara kredit. Bai’ Tawarruq adalah akad jual beli yang melibatkan tiga pihak dengan tujuan memperoleh uang tunai. Sementara itu, Bai’ Bitsaman Ajil adalah akad jual beli dengan pembayaran secara cicilan. Hasil penelitian menunjukkan bahwa tiap akad memiliki perbedaan dalam hal tujuan dan penerapan syarat. Bai’ al-Wafa’ dianggap sah oleh sebagian ulama, sedangkan Bai’ al-‘Inah dan Bai’ Tawarruq sering diperdebatkan karena dianggap dapat mengarah pada praktik riba. Bai’ Bitsaman Ajil umumnya diterima sebagai pembiayaan berbasis jual beli yang sah dalam praktik perbankan syariah.
MODEL KOMUNIKASI HUMAS PEMERINTAH KABUPATEN HULU SUNGAI TENGAH DALAM MENYEBARLUASKAN INFORMASI KEAGAMAAN
Authors: Farida Herliani
Published: January 2025

Komunikasi merupakan aktivitas dasar dari kehidupan manusia, melalui komunikasi manusia dapat saling bertukar pikiran maupun informasi. Penelitian ini dilatarbelakangi atas dasar ketertarikan penulis untuk mengetahui sekaligus menggali lebih dalam tentang model komunikasi yang diterapkan oleh Humas Pemerintah Kabupaten Hulu Sungai Tengah dalam proses penyebarluaskan informasi keagamaan kepada masyarakat jika dilihat dari kajian humas. Maka dari itu peran komunikasi di sini penting untuk diteliti karena sukses atau tidaknya penyebarluasan informasi juga ditentukan oleh model komunikasi seperti apa yang digunakan. Penelitian ini menggunakan metode deskriptif kualitatif yang mana hasil dari penelitian yang diperoleh di lapangan melalui wawancara dan dokumentasi akan dianalisis menggunakan analisis kualitatif kemudian dijelaskan dan digambarkan dalam bentuk kalimat. Subjek dalam penelitian ini adalah Humas pemerintah kabupaten Hulu Sungai Tengah adapun objek nya adalah Model komunikasi humas pemerintah kabupaten Hulu Sungai Tengah dalam menyebarluaskan informasi keagamaan.
PERAN HUMAS DALAM MENINGKATKAN KEPERCAYAAN PUBLIK TERHADAP PEMERINTAH
Authors: Hasan Husaini
Published: January 2025

Kepercayaan publik terhadap pemerintah merupakan elemen vital dalam menjamin stabilitas dan keberhasilan program-program pemerintah. Humas (Hubungan Masyarakat) memiliki peran strategis dalam membangun, memelihara, dan meningkatkan kepercayaan publik melalui komunikasi yang efektif, transparansi, dan hubungan yang saling menguntungkan antara pemerintah dan masyarakat. Artikel ini bertujuan untuk menganalisis peran humas dalam meningkatkan kepercayaan publik terhadap pemerintah, dengan fokus pada strategi komunikasi, pengelolaan krisis, serta penerapan teknologi informasi dalam praktik humas. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi literatur untuk menggali konsep-konsep utama dan studi kasus yang relevan. Hasil penelitian menunjukkan bahwa humas yang proaktif, adaptif, dan berbasis data dapat menjadi kunci dalam membangun hubungan yang harmonis antara pemerintah dan masyarakat.
Comparison of Static and Spect Images on Tc-99m-PYP Bone Scintigraphy in the Diagnosis of Cardiac Amyloidosis
Authors: Aydın Akpınar Emine , Özcan Pınar Pelin , Koç Zehra Pınar , Gümüş Adil , Yavan Gökçe
Published: January 2025

Amyloidosis is a systemic disease characterized by the extracellular accumulation of amyloid fibrils caused by misfolding of proteins. Cardiac amyloidosis has the worst prognosis of the type of organ involvements. The most common forms of cardiac amyloidosis are immunoglobulin light chain amyloidosis (AL) and transtretin (TTR) amyloidosis. The developing diagnostic methods give the clinician early diagnosis of cardiac amyloidosis. Scintigraphic imaging with Technetium (Tc-99m) labelled biphosponates may faciliate early detection of cardiac involvement and distinguish various forms of cardiac amyloidosis. Bone scintigraphy for evaluation of cardiac amyloidosis especially for ATTR type amyloidosis is one of the most sensitive imaging prosedures in recent years. In our study, we compared the 1st and 3rd hour planar and SPECT imaging to investigate the importance of the 3rd hour and the necessity of SPECT in cardiac amyloidosis (CA) imaging, which is one of the controversial topics from the Nuclear Medicine perspective.
Prawne uwarunkowania realizacji Strategii na Rzecz Odpowiedzialnego Rozwoju w obszarze energetyki ze szczególnym uwzględnieniem elektromobilności
Authors:   Wydział Prawa i Administracji Uniwersytetu Warszawskiego, Szafrański Adam
Published: January 2025

W artykule wymieniono projekty strategiczne w obszarze energetyki zawarte w Strategii na rzecz Odpowiedzialnego Rozwoju. Autor wskazał na dwa projekty w szczególny sposób wymagające nowych regulacji prawnych, tj. rynek mocy oraz rozwój elektromobilności. Następnie skupił się na wskazaniu podstawowych barier prawnych rozwoju elektromobilności z pominięciem barier o charakterze finansowym, gdzie regulacje prawne są niezbędne, ale akcesoryjne wobec wydatkowania środków publicznych. Do podstawowych kwestii wymagających uregulowania autor zaliczył konieczność zdefiniowania stron zaangażowanych w świadczenie usługi ładowania pojazdu elektrycznego, wyjaśnienie wątpliwości z zakresu prawa energetycznego (wymóg koncesji) oraz prawa budowalnego (wymóg pozwolenia budowalnego). Następnie autor przeanalizował planowane przepisy zawarte w projekcie ustawy o elektromobilności i paliw alternatywnych w kontekście wskazanych przeze siebie wątpliwości. W wyniku tej analizy autor doszedł do wniosku, że projekt ustawy jest spójny i zorientowany na przyszłość, ale pomija obecnie istniejącą infrastrukturę, tym samym zagadnienia wymagające regulacji w pewnym zakresie takimi nadal pozostaną, o ile przepisy zostaną uchwalone przez Sejm w obecnym brzmieniu projektu.
Koncesja jako prawny instrument bezpieczeństwa energetycznego
Authors:   Katedra Prawa i Postępowania Administracyjnego Wydziału Prawa i Administracji Uniwersytetu Warszawskiego, Elżanowski Filip , Manteuffel Piotr
Published: January 2025

W artykule przedstawiono próbę oceny koncesji udzielanej przez Prezesa URE jako instrumentu prawnego służącego zapewnieniu bezpieczeństwa energetycznego. W ramach przeprowadzonej analizy przedstawiono poszczególne przesłanki udzielania koncesji podmiotom zamierzającym prowadzić działalność gospodarczą na rynku energetycznym oraz zakres badania ich spełniania przez wnioskodawcę, przeprowadzanego przez organ regulacyjny w toku postępowania koncesyjnego. Analizie poddana została ponadto ustawa z dnia 22 lipca 2016 r. o zmianie ustawy – Prawo energetyczne oraz niektórych innych ustaw, jako aktualny przykład rozwiązania legislacyjnego, mającego w zamierzeniu ustawodawcy służyć zapewnieniu bezpieczeństwa energetycznego. W ostatniej części artykułu wskazano również na zasadność dokonania refleksji dotyczącej poprawności niektórych stosowanych w praktyce interpretacji nowych lub zmienionych przepisów ww. ustawy w świetle celu, jakiemu służyć ma instrument koncesjonowania działalności gospodarczej na rynku energetycznym.
Umowa biletowa – wybrane zagadnienia praktyczne
Authors:   Katedra Europejskiego Prawa Gospodarczego na Wydziale Prawa i Administracji Uniwersytetu Łódzkiego, Kraśniewski Marcin
Published: January 2025

W artykule podjęto próbę przybliżenia nowej formy realizacji obowiązku utrzymywania obowiązkowych zapasów gazu ziemnego, jaką jest umowa biletowa. Dokonano w nim prezentacji dwóch nowelizacji ustawy o zapasach ropy naftowej, produktów naftowych i gazu ziemnego oraz zasadach postępowania w sytuacjach zagrożenia bezpieczeństwa paliwowego państwa i zakłóceń na rynku naftowym. Przedstawiono wątpliwości i konsekwencje skutków ukształtowanej w nich instytucji prawnej, jaką jest umowa biletowa. Omówiono zakres przedmiotowy i podmiotowy umowy, a także formę, charakter i zakres kontroli dokonywanej przez Prezesa Urzędu Regulacji Energetyki, miejsce utrzymywania zapasów obowiązkowych gazu ziemnego na podstawie umowy biletowej oraz odpowiedzialność, jaką ponoszą strony umowy.
Wpływ EKPC na uwzględnianie „winy” jako przesłanki dopuszczalności nakładania kar pieniężnych w orzecznictwie dotyczącym deliktów prawa antymonopolowego i energetycznego
Authors:   Katedra Europejskiego Prawa Gospodarczego WPiA UŁ, Urbańska-Arendt Marta
Published: January 2025

Standardy ochrony praw podmiotowych wytyczone przez EKPC sprawiają, że elementy subiektywnego stosunku sprawcy do czynu bywają traktowane w polskim orzecznictwie sądowym jako przesłanka dopuszczalności nałożenia kar pieniężnych za popełnienie deliktów stypizowanych w ustawie o ochronie konkurencji i konsumentów oraz w ustawie – Prawo energetyczne. Artykuł analizuje orzecznictwo począwszy od roku 2010 do dnia dzisiejszego w celu ustalenia czy zarysowała się stała tendencja orzecznicza, która w wyniku uwzględniania norm EKPC uznaje „winę” za przesłankę dopuszczalności nakładania kar pieniężnych za te delikty prawa antymonopolowego i prawa energetycznego oraz do jakich argumentów odwołują się sądy w celu uzasadnienia powyższego, skoro przepisy ww. ustaw nie statuują takiej przesłanki.
Les procédés humoristiques les plus fréquemment utilisés par Jacques Goldstyn dans la série Van l’inventeur
Authors: DeRoy-Ringuette Rachel
Published: January 2025

Parmi les créateurs qui visent un jeune lectorat et qui pratiquent l’humour en bande dessinée, nous avons choisi d’étudier le cas de Jacques Goldstyn. Au sein de son univers foisonnant, nous limitons notre propos à sa série Van l’inventeur. Nous avons choisi cette série parce qu’elle couvre deux décennies et que ses cinq tomes présentent une certaine uniformité. Notre objectif est de dégager les procédés humoristiques les plus fréquents dans la série de bandes dessinées Van l’inventeur de Jacques Goldstyn. Afin d’atteindre cet objectif, nous estimons pertinent de brosser un portrait sommaire de l’auteur-illustrateur pour mieux comprendre son univers humoristique. Ensuite, nous survolons le concept des attraits du livre (Saricks, 2005; 2009), car les procédés humoristiques utiles à notre propos y sont directement liés. Puis nous présentons notre méthodologie, qui comprend une grille de différents procédés humoristiques (Montésinos-Gelet, DeRoy-Ringuette et Dupin de Saint-André, 2021) afin de dresser un portrait quantitatif de leur utilisation. Enfin, nous exposons nos résultats après l’analyse des planches de la série Van l’inventeur.
Les premiers appartements de Nouvelle adresse1
Authors: Tremblay-Gaudette Gabriel
Published: January 2025

Nouvelle adresse est une jeune maison d’édition de bande dessinée québécoise qui, à l’exception de deux oeuvres de Philippe Girard, un vétéran du neuvième art québécois, s’est jusqu’à présent consacrée à la publication des premières oeuvres d’artistes de la relève. Notre article explore plusieurs oeuvres parues chez cette recrue de la scène de la bande dessinée québécoise afin d’en repérer les lignes de force. Les thématiques très variées abordées dans les oeuvres pourraient donner à croire que les oeuvres parues chez Nouvelle adresse se suivent, mais ne se ressemblent pas. Or, à bien y regarder, nous remarquons, par les témoignages contenus dans ces albums qui appartiennent de manières diverses à la « bande dessinée du réel », une réflexion sur la genèse, sur une forme de commencement, qui se déploie notamment par l’utilisation des codes de la bande dessinée que chaque artiste découvre et met en pratique pour la première fois. Il s’agira donc de mettre l’accent sur les poétiques de la création qui se déploient dans ces oeuvres afin de comprendre comment celles-ci en viennent à définir une ligne éditoriale distincte.
Thomas B. Edsall on the Convicted Felon Trump, and Walter J. Ong’s Thought
Authors: Farrell Thomas J.
Published: January 2025

In my wide-ranging 3,300-word essay, I first briefly introduce the life and work of the American Jesuit Renaissance specialist and cultural historian and pioneering media ecology theorist Walter J. Ong (1912-2003; Ph.D. in English, Harvard University, 1955). Then I discuss Thomas B. Edsall’s op-ed column “Trump Would Be Long Gone if Only We Could . . . ” (dated June 12, 2024) in the New York Times.
Young Lynda Carter as Wonder Woman, and Walter J. Ong’s Thought
Authors: Farrell Thomas J.
Published: January 2025

In the first part of my article, I discuss the beautiful young Lynda Carter (born in 1951) who played Wonder Woman in the Wonder Woman television series (1976-1979). As I watched the beautiful young Lynda Carter in her wonderfully revealing Wonder Woman costume, I responded to her beauty by projecting the optimal and positive form of the feminine Lover archetype in my psyche onto her, thereby making her beauty appear more attractive to me. In the second part of my article, I discuss the work of the American Jesuit Renaissance specialist and cultural historian and pioneering media ecology theorist Walter J. Ong (1912-2003; Ph.D. in English, Harvard University, 1955) of Saint Louis. Also in the second part of my article, I discuss two books by the Jungian psychoanalyst Erich Neumann (1954, 1955) and five books about the masculine archetypes of maturity by Robert Moore and Douglas Gillette (1990, 1992,1993). In the final part of my article, I return to the beautiful young Lynda Carter as Wonder Woman to offer my final reflections about Wonder Woman as a superheroine.
A Probe of John Dominic Crossan’s 2022 Book Render Unto Caesar, and Walter J. Ong’s Thought
Authors: Farrell Thomas J.
Published: January 2025

I style my short essay here as a probe because it is exploratory in nature. In it, I use certain points from the work of the American Jesuit Walter J. Ong (1912-2003; Ph.D. in English, Harvard University, 1955) to explore possible alignments withcertain points in the Irish American biblical scholar John Dominic Crossan’s 2022 book Render Unto Caesar: The Struggle Over Christ and Culture in the New Testament.
Probe: Chinua Achebe’s Things Fall Apart (1958) and No Longer at Ease (1960), and Walter J. Ong’s Thought
Authors: Farrell Thomas J.
Published: January 2025

In a contrapuntal organizational pattern, I discuss Chinua Achebe’s novels Things Fall Apart (1958) and No Longer at Ease (1960), on the one hand, and, on the other, the mature work of the American Jesuit Renaissance specialist and cultural historian and pioneering media ecology theorist Walter J. Ong (1912-2003; Ph.D. in English, Harvard University, 1955) of Saint Louis University. I style this short essay as a “Probe” because it is fundamentally exploratory in nature.
Probe: Robert Moore’s Thought on Optimal Human Psychological Development, and Walter J. Ong’s Thought
Authors: Farrell Thomas J.
Published: January 2025

In my deeply personal and candid probe I explore highlights of the thought of the late Jungian psychotherapist and theorist Robert Moore (1942-2016; Ph.D. in religion and psychology, University of Chicago, 1975) of the Chicago Theological Seminary. In addition, I explore highlights of the historical thought of the late American Jesuit Renaissance specialist and cultural historian and pioneering media ecology theorist Walter J. Ong (1912-2003; Ph.D. in English, Harvard University, 1955) of Saint Louis University – where I took five courses from him over the years.My favorite scholar is the American Jesuit Renaissance specialist and cultural historian and pioneering media ecology theorist Walter J. Ong (1912-2003; Ph.D. in English, Harvard University, 1955) of Saint Louis University – where I took five courses from him over the years.
Alegria é devoção: sambas, santos e novenas numa tradição afro-diaspórica da Bahia
Authors: Iyanaga Michael
Published: January 2025

Em Alegria é devoção, Michael Iyanaga nos oferece uma análise inédita e minuciosa sobre uma das mais significativas tradições afro-diaspóricas da Bahia: a tradição domiciliar de sambar e cantar para São Roque, São Cosme, Santo Antonio e outros santos de devoção. Fundamentado em mais de dez anos de pesquisas históricas, antropológicas e musicológicas, o estudo apresenta os pormenores dessa tradição baiana, as músicas e as vidas dos devotos e das devotas, sempre realçando o seu legado africano. A partir daí, o autor questiona conceitos acadêmicos consagrados como “sincretismo”, “catolicismo popular” e outros. Alegria é devoção nos revela mais uma face da vasta complexidade religiosa e cultural da diáspora africana no Brasil.
A luta da África por sua arte: história de um malogro pós-colonial
Authors: Savoy Bénédicte
Published: January 2025

Este livro é dedicado àquilo que vem sendo reprimido. Ele começa em 1965, com um dos primeiros apelos para a devolução de arte para a África, e termina em 1985, na Ilha dos Museus, na então Berlim Oriental, quando a Nigéria não alinhada estreou com uma exposição de seus tesouros arqueológicos no Museu Pergamon – para, depois de duas décadas de lutas mais tarde, perder toda a esperança de uma restituição. O livro é a primeira tentativa de escrever a história coerente de um malogro pós-colonial com base na profusão de material a respeito espalhado em inúmeros arquivos europeus e publicações africanas. Trata-se de um malogro compartilhado, lembremo-nos, pois a recusa de restituições aos países africanos nas primeiras décadas de sua independência não representou, de forma alguma, um capítulo glorioso da história da Europa. (Da Introdução)
Learning of state representation in recurrent network: the power of random feedback and biological constraints
Authors: Tsurumi Takayuki , Kato Ayaka , Kumar Arvind , Morita Kenji
Published: January 2025

How external/internal ‘state’ is represented in the brain is crucial, since appropriate representation enables goal-directed behavior. Recent studies suggest that state representation and state value can be simultaneously learnt through reinforcement learning (RL) using reward-prediction-error in recurrent-neural-network (RNN) and its downstream weights. However, how such learning can be neurally implemented remains unclear because training of RNN through the ‘backpropagation’ method requires downstream weights, which are biologically unavailable at the upstream RNN. Here we show that training of RNN using random feedback instead of the downstream weights still works because of the ‘feedback alignment’, which was originally demonstrated for supervised learning. We further show that if the downstream weights and the random feedback are biologically constrained to be non-negative, learning still occurs without feedback alignment because the non-negative constraint ensures loose alignment. These results suggest neural mechanisms for RL of state representation/value and the power of random feedback and biological constraints.
Behavioural pharmacology predicts disrupted signalling pathways and candidate therapeutics from zebrafish mutants of Alzheimer’s disease risk genes
Authors: Kroll François , Donnelly Joshua , Özcan Güliz Gürel , Mackay Eirinn , Rihel Jason
Published: January 2025

By exposing genes associated with disease, genomic studies provide hundreds of starting points that should lead to druggable processes. However, our ability to systematically translate these genomic findings into biological pathways remains limited. Here, we combine rapid loss-of-function mutagenesis of Alzheimer’s risk genes and behavioural pharmacology in zebrafish to predict disrupted processes and candidate therapeutics. FramebyFrame, our expanded package for the analysis of larval behaviours, revealed that decreased night-time sleep was common to F0 knockouts of all four late-onset Alzheimer’s risk genes tested. We developed an online tool, ZOLTAR, which compares any behavioural fingerprint to a library of fingerprints from larvae treated with 3,677 compounds. ZOLTAR successfully predicted that
sorl1
mutants have disrupted serotonin signalling and identified betamethasone as a drug which normalises the excessive day-time sleep of
presenilin-2
knockout larvae with minimal side effects. Predictive behavioural pharmacology offers a general framework to rapidly link disease-associated genes to druggable pathways.
Persistent cross-species transmission systems dominate Shiga toxin-producing Escherichia coli O157:H7 epidemiology in a high incidence region: a genomic epidemiology study
Authors: Tarr Gillian AM , Chui Linda , Stanford Kim , Bumunang Emmanuel W , Zaheer Rahat , Li Vincent , Freedman Stephen B , Laing Chad R , McAllister Tim A
Published: January 2025

Several areas of the world suffer notably high incidence of Shiga toxin-producing
Escherichia coli
, among them Alberta, Canada. We assessed the impact of persistent cross-species transmission systems on the epidemiology of
E. coli
O157:H7 in Alberta.We sequenced and assembled 229
E. coli
O157:H7 isolates originating from collocated cattle (n=108) and human (n=121) populations from 2007-2015 in Alberta. We constructed a timed phylogeny using BEAST2 using a structured coalescent model. We then extended the tree with human isolates through 2019 (n=430) to assess the long-term disease impact of locally persistent lineages. Shiga toxin gene (
stx
) profile was determined for all isolates.During 2007 to 2015, we estimated 108 (95% HPD 104, 112) human lineages arose from cattle lineages, and 14 (95% HPD 5, 23) from other human lineages; i.e., 88.5% of human lineages arose from cattle lineages. We identified 11 persistent lineages local to Alberta, which were associated with 38.0% (95% CI 29.3%, 47.3%) of human isolates. Of 117 isolates in locally persistent lineages, 6.0% carried only the Shiga toxin gene
stx2a
and the rest both
stx1a
and
stx2a
. During the later period, six locally persistent lineages continued to be associated with human illness, including 74.7% (95% CI 68.3%, 80.3%) of reported cases in 2018 and 2019. The
stx
profile of isolates in locally persistent lineages shifted from the earlier period, with 51.2% encoding only
stx2a
.Our study identified multiple locally evolving lineages transmitted between cattle and humans persistently associated with
E. coli
O157:H7 illnesses for up to 13 years. Of concern, there was a dramatic shift in locally persistent lineages toward strains with the more virulent
stx2a
-only profile. Locally persistent lineages may be a principal cause of the high incidence of
E. coli
O157:H7 in locations such as Alberta and offer opportunities for understanding the disease ecology supporting
E. coli
O157:H7 persistence, as well as for local prevention efforts.
The Effect of Decision Support Systems on Strategic Business Decisions: Evidence from Manufacturing Companies in Nigeria
Authors: Matthew Alake Adesoji , Awodiran Muideen A. , Ayomide Akinleye Nathan , Foluke Adeyemo
Published: January 2025

This study examined the evaluation of the effect of Decision Support System on Strategic Business Decisions from selected manufacturing companies in Nigeria. The effective utilization of decision support system is crucial in driving business decisions, yet its impact on decision making within Nigeria manufacturing companies remains underexplored. This study examined the evaluation of the effect of Decision Support System on Strategic Business Decisions from selected manufacturing companies in Nigeria. The study employed a qualitative survey research design. The population for the study comprised top-level managers, middle managers, and operational managers from 34 listed manufacturing companies in Nigeria Exchange Group. A stratified random sampling technique was employed to select 1,014 samples. Taro Yamane’s formula was employees to select the sample size of 286 respondents. Data collection is collected through a close ended questionnaire based on a five likert scale, designed to assess perceptions and practices related to decision support system. The data were analyzed using ordinary regression analysis to estimate the relationship between the dependent and independent variables. The findings revealed positive significant association between decision support system on strategic business decisions. This study hereby recommended Nigeria Manufacturing companies should invest in robust decision support systems to ensure continuous improvement and accountability. This study concludes that effective implementation and enhancement of decision support system can sustainably impact business decision process in Nigeria manufacturing companies.
Exploring the Impact of Islamic Finance Principles on Micro and Small Enterprise Performance: A Literature Review
Authors: Baina Nakanwagi , Andrew Nyakundi , Micheal Manyange
Published: January 2025

Both micro and small enterprises (MSEs) can drive economies to growth and eradicate poverty, but numerous challenges challenge their finances. The principles of Islamic finance, with other-centered equity, ethical quality, and risk-sharing, have the potential to considerably benefit MSE development and commercialization as compared to conventional systems. This review systematically analyzes existing literature relating Islamic finance principles to MSE performance based on the synthesis of work conducted in Uganda, Oman, Indonesia, and Nigeria with an objective of identifying the gaps to be covered by the preceding empirical study using a qualitative approach. The findings show a positive relationship between the application of mechanisms of Islamic finance, including profit-sharing, interest-free financing, and partnership-based models, and the business performance indicators of profitability, revenue growth, and sustainability. However, the review pinpointed major gaps in available research, including a constricted geographical cover, a small sample size of enterprises, and inadequate gender-dimensional exploration. Further, some inherent methodological inconsistencies, such as ambiguous performance indicators and sampling biases, additionally hamper the generalization of findings. To overcome such gaps, this study suggests that research should be extended into the rural and less-represented regions, should explore gender issues, and should use more solid methodological approaches. This would enable researchers, policy-makers, and financing bodies to appreciate and utilize the very full potential of the principles of Islamic finance in empowering MSEs to promote inclusive economic development.
Genetic Variability, Heritability and Genetic Advance for Yield and Yield Related Traits in Rice (Oryza Sativa L.)
Authors: Soundharya B. , Edukondalu B. , G.Narender  , Dinesh A.
Published: January 2025

Aims: To evaluate genetic variability, heritability, and genetic advance for key agronomic traits in rice to identify traits with high potential for selection and improvement in breeding programs.
Experimental Design: The experiment was conducted in a randomized block design (RBD) with three replications.
Place and Duration of Study: Regional Sugarcane and Rice Research Station (RS&RRS), Rudrur, Nizamabad, during the kharif 2022 season.
Methodology: Eighteen Advanced Varietal Trial (AVT) entries were evaluated with a spacing of 20 cm × 15 cm. Data were recorded from five randomly selected plants per entry in each replication for agronomic and yield-related traits: days to 50% flowering (DFF), plant height (PH), panicle length, number of panicles per square meter, filled grains per panicle, 1000-grain weight, and grain yield per hectare (GY/ha). Analysis of variance (ANOVA) and genetic parameters, including environmental coefficient of variation (ECV), genotypic and phenotypic coefficients of variation (GCV and PCV), heritability (h²), and genetic advance as a percentage of the mean (GAM), were calculated using Windostat Version 9.1.
Results: The ECV was low across all traits, indicating minimal environmental influence. GCV was low for DFF (4.957%) and PH (4.789%) but moderate for filled grains per panicle (15.874%) and 1000-grain weight (16.33%). PCV was slightly higher than GCV for most traits, confirming limited environmental effects. Heritability ranged from medium (37.4% for GY/ha) to very high (99.7% for 1000-grain weight). GAM was high for filled grains per panicle (31.96%) and 1000-grain weight (33.586%), indicating strong potential for genetic improvement.
Conclusion: Traits with high heritability and genetic advance, such as filled grains per panicle and 1000-grain weight, are ideal for selection. These findings will aid in enhancing rice breeding programs through targeted genetic improvement.
Enhancing the Trapping of Melon Fruit Fly, Zeugodacus cucurbitae Coquilette through Synergizing the Odour and Visual Cues
Authors: Aarthi R. , Kavitha Zadda , Shanthi M. , Vijayaraghavan C. , Srinivasan G. , Mini M. L.
Published: January 2025

The melon fruit fly (Zeugodacus cucurbitae Coquillett) poses a significant threat to cucurbit crops with substantial yield losses and challenging sustainable vegetable production. This study systematically investigated efficient color-based visual cues for attracting melon flies and explored the synergistic effects of these visual cues in conjunction with odour cues. This study was conducted in Agricultural College and Research Institute, TNAU, Madurai during 2024. Our studies included investigations on preferred colour by melon fly through olfactometer & insect cage bioassays in no choice & multiple choice conditions. The additive effect of the preferred colour when combined with the fruit fly attractive odour cue was investigated under field conditions. For both male and female melon fruit flies, yellow colour (RBG coordinates - 255:255:0) consistently emerged as the most efficient visual cue followed by white (255:255:255) and red (255:0:0). Field trials also confirmed the attractiveness of yellow colour as it outperformed other colours. The visual cue, yellow colour and odour cue (synthetic blend of four fruit fly EAG active synthetic compounds in a known ratio) were combined and found to be synergistic as this fusing captured significantly more flies than the either cues alone. These results highlighted the yellow colour as the most attractive visual cue for melon flies and combining effective of visual cues with established odour attractant to greatly enhance the trapping efficiency. This integrated approach offers a promising strategy for the management of melon fly and reduction of reliance on chemical pesticides contributing to more sustainable pest control in cucurbit production. The findings have significant implications for pest management strategies, especially in regions facing melon fly infestations that threaten crop yields and export potential.
Storage Stability and Probiotic Viability of Foxtail Millet Probiotic Powder Enriched with High Protein and Fiber
Authors: Santhosh Aiswarya Velekat , Sweety  , T S Asif Ali , B Ramachandra
Published: January 2025

Aims: The study aimed to evaluate the storage stability of foxtail millet probiotic powder enriched with high protein and dietary fiber under two storage conditions: room temperature (27 ± 1°C) and refrigeration temperature (7 ± 1°C).
Study Design: This was an experimental, laboratory-based study.
Place and Duration of Study: The study was conducted at the Department of Dairy Microbiology, Dairy Science College, Hebbal, Bengaluru, Karnataka, India, between January 2024 and October 2024.
Methodology: Foxtail millet probiotic powder enriched with high protein and dietary fiber was stored in polypropylene sachets under two storage conditions: room temperature and refrigeration temperature. Samples were systematically drawn at 7-day intervals and analyzed for key quality parameters, including probiotic viability, microbial contaminants, water activity, moisture content, alcoholic acidity, and pH. Statistical analyses were performed using Analysis of Variance (ANOVA), with a 5% significance level. A critical difference (CD) value was employed to determine the statistical significance of observed variations between treatments over the storage period.
Results: The storage stability of the optimized foxtail millet probiotic dry mix was assessed at both room temperature (27 ± 1°C) and refrigeration (7 ± 1°C) until spoilage or decline in probiotic viability below the threshold value. Probiotic viability declined significantly under both conditions, with a reduction from 11.04 log₁₀ CFU/g to 8.88 log₁₀ CFU/g at room temperature and 8.81 log₁₀ CFU/g under refrigeration. Water activity and moisture content increased over time, reflecting the hygroscopic nature of the mix, while alcoholic acidity rose significantly in both storage conditions. Despite these changes, the mix maintained probiotic viability above the therapeutic threshold (9 log₁₀ CFU/g) for 84 days at room temperature and 105 days under refrigeration, demonstrating its potential as a stable functional food product.
Conclusion: The storage study of foxtail millet probiotic powder demonstrated its stability under both refrigeration and ambient conditions, with probiotic viability exceeding the 1 billion CFU/g threshold for up to 105 days and 84 days, respectively. Significant changes in water activity, moisture content, alcoholic acidity, and pH were observed, highlighting the product’s dynamic response to storage conditions.These results support the feasibility of developing shelf-stable, high-protein, high-fiber probiotic millet powders for the health-conscious market.
Narrative medicine workshops for emergency medicine residents: Effects on empathy and burnout
Authors: Malik Zayir , Ahn James , Schwartz Alan , Blackie Michael
Published: July 2023

Background

Emergency medicine (EM) residents face unique affective challenges and barriers to interpersonal connection in their clinical environment which may contribute to decreased empathy and increased burnout. Narrative medicine (NM) might address these barriers and has had beneficial impacts in various populations but has never been studied in EM residents. In this study, we sought to evaluate the effect of NM workshops on burnout and empathy and to assess resident perceptions of the workshops.

Methods

We performed a quasi‐experimental study at two EM residencies from June to October 2020. Residents at the intervention site participated in two NM workshops led by EM faculty that were composed of a close reading of a literary text, reflective writing, and group discussion. Residents were asked to complete the abbreviated Interpersonal Reactivity Index (IRI) and a single‐item burnout measure pre‐ and postintervention. We fitted linear regression models to IRI subscores; we treated burnout as an ordinal variable and fitted a conditional logistic regression model. Residents completed a postintervention survey that we analyzed using summary statistics.

Results

A total of 46.7% of control (28/60) and 100% of intervention (48/48) residents responded (n = 76). While all respondents demonstrated worsening burnout with time (p = 0.001), residents at the intervention site exhibited less severe increases (interaction p < 0.001). Empathy remained unchanged. A total of 50% of intervention residents (24/48) responded to the postintervention survey; most (n = 20, 83.3%) agreed that the workshops should be a standard part of EM didactics.

Conclusions

These findings establish the feasibility and desirability of NM in residency education and offers a model for EM‐centered narrative workshops. Additionally, while our outcomes are limited, we found that exposure to an NM curriculum may be protective against worsening burnout.
The snow‐shadow effect of Sado Island on Niigata City and the coastal plain
Authors: Kusaka Hiroyuki , Suzuki Nobuyasu , Yabe Masato , Kobayashi Hiroki
Published: July 2023

Japan's Hokuriku region, near the Sea of Japan, typically experiences heavy snowfall; however, Niigata City, the largest city on the Sea of Japan side, experiences lower levels of snowfall than neighbouring cities. This study investigates the snow‐shadow effect of Sado Island on snowfall in Niigata City, located 45 km away leeward. Statistical analysis of long‐term radar data for 10 winters showed that snow‐shadow effects in the Niigata plain occurred in 151 (80%) of the 188 cases, during which a strong approaching wind reached the island. The location of this snow‐shadow effect was always downwind of Sado Island and depended on the wind direction. Numerical experiments using the Weather Research and Forecasting model predicted that snowfall over the Niigata Plain would be lighter with the island than without it. Additionally, the snow‐shadow effect occurs in areas more than 150 km downwind. The experiments showed that Sado Island reduces heat fluxes from the sea surface by weakening leeward winds. At the same time, the horizontal wind convergence downwind is weakened. Meanwhile, the orographic snowfall over Sado Island reduces the amount of water vapour, cloud water and cloud ice over the leeward sea. Therefore, Sado Island prevents cloud lines from redeveloping over the leeward sea and can further reduce snowfall over the leeward plain, including in Niigata City.
Tmax volume can predict clinical type in patients with acute ischemic stroke
Authors: Kishi Fumihisa , Nakagawa Ichiro , Kimura Seigo , Ogawa Daiji , Yagi Ryokichi , Yamada Keiichi , Taniguchi Hirokatsu
Published: July 2023

Objective

Endovascular therapy (EVT) is performed for acute ischemic stroke (AIS) with large vessel occlusion (LVO), however, the treatment strategies and clinical outcomes differ between cardiac embolism (CE) and intracranial arteriosclerosis‐derived LVO (ICAS‐LVO). We analyzed whether the time‐to‐max (Tmax) volume derived from perfusion imaging predicted clinical classification in AIS patients before EVT.

Methods

Consecutive AIS patients with anterior circulation LVO evaluated by automated imaging software were retrospectively identified. Patients were classified into a CE group and an ICAS‐LVO group, and parameters were compared between groups.

Results

Thirty‐nine patients were included and Tmax volume and Tmax > 6 s volume/Tmax > 4 s volume were significantly greater in the CE group than in the ICAS‐LVO group (Tmax > 4 s volume: 261 mL vs. 149 mL, p = .01, Tmax > 6 s volume: 143 mL vs. 59 mL, p = .001, Tmax > 6 s volume/Tmax > 4 s volume: 0.59 vs. 0.40, p < .001). Multiple logistic regression analysis indicated an association between clinical classification and high Tmax > 6 s volume/Tmax > 4 s volume (p = .04).

Conclusion

The Tmax volume derived from perfusion imaging predicts the clinical classification of AIS patients before EVT.
DNA Nanobarrel‐Based Drug Delivery for Paclitaxel and Doxorubicin
Authors: Wang Jiaoyang , Zhang Tianyu , Li Xueqiao , Wu Wenna , Xu Hui , Xu Xin‐ming , Zhang Tao
Published: July 2023

Co‐delivery of anticancer drugs and target agents by endogenous materials is an inevitable approach towards targeted and synergistic therapy. Employing DNA base pair complementarities, DNA nanotechnology exploits a unique nanostructuring method and has demonstrated its capacity for nanoscale positioning and templated assembly. Moreover, the water solubility, biocompatibility, and modifiability render DNA structure suitable candidate for drug delivery applications. We here report single‐stranded DNA tail conjugated antitumor drug paclitaxel (PTX), and the co‐delivery of PTX, doxorubicin and targeting agent mucin 1 (MUC‐1) aptamer on a DNA nanobarrel carrier. We investigated the effect of tail lengths on drug release efficiencies and dual drug codelivery‐enabled cytotoxicity. Owing to the rapidly developing field of structural DNA nanotechnology, functional DNA‐based drug delivery is promising to achieve clinical therapeutic applications.
Task‐based preemptive scheduling on FPGAs leveraging partial reconfiguration
Authors: Rodriguez‐Canal Gabriel , Brown Nick , Torres Yuri , Gonzalez‐Escribano Arturo
Published: July 2023

Field‐programmable gate arrays (FPGAs) are an attractive type of accelerator for all‐purpose high performance computing computing systems due to the possibility of deploying tailored hardware on demand. However, the common tools for programming and operating FPGAs are still complex to use, especially in scenarios where diverse types of tasks should be dynamically executed. In this work, we present a programming abstraction with a simple interface that internally leverages high‐level synthesis, dynamic partial reconfiguration and synchronization mechanisms to use an FPGA as a multi‐tasking server with preemptive scheduling and priority queues. This leads to an improved use of the FPGA resources, allowing the execution of several different kernels concurrently and deploying the most urgent ones as fast as possible. The results of our experimental study show that our approach incurs only a 10 5% overhead in the worst case when using two reconfigurable regions, whilst providing a significant performance improvement of at least 24 21% over the traditional full reconfiguration approach.
Trait‐independent habitat associations explain low co‐occurrence in native and exotic birds on a tropical volcanic island
Authors: Barnagaud Jean‐Yves , Flores Olivier , Balent Gérard , Tassin Jacques , Barbaro Luc
Published: July 2023

On oceanic islands, strong human impacts on habitats, combined with introductions of exotic species, modify the composition of terrestrial bird assemblages and threaten their ecological functions. In La Réunion, an oceanic island located in the Madagascan region, a national park was established in 2007 to counter the ecosystem‐level effects of three centuries of habitat conversion, native species destruction and exotic species introductions. Here, we investigated how bird assemblages were structured in these human‐modified landscapes, 10 years before the national park set out its first conservation measures. We used a combination of multivariate statistics and generalized additive models to describe variations in the taxonomic and functional composition and diversity of 372 local bird assemblages, encompassing 20 species, along gradients of habitat composition and configuration. We found that native species were tied to native habitats while exotic species were associated with urban areas and man‐modified landscape mosaics, with some overlap at mid‐elevations. Species' trophic preferences were segregated along habitat gradients, but ecological traits had an overall weak role in explaining the composition of species assemblages. Hence, at the time of the survey, native and exotic species in La Réunion formed two spatially distinct species assemblages with contrasting ecological trait suites that benefited from antagonistic habitat compositions and dynamics. We conclude that our results support the analysis of historical data sets to establish reference points to monitor human impacts on insular ecosystems.