bluuebunny/crossref_metadata_2025 huggingface dataset:
Dongeng Berbasis Kearifan Lokal Sebagai Strategi Meningkatkan Minat Baca
Authors: Indrayani Rusmiati , Satriah Satriah , Jinan Qatrunnada , Rahayu Selvi Dewi , Ramdhani Ratna Dwi , Juliana Juliana
Published: November 2024

Mendongeng merupakan tradisi masyarakat yang sudah ada sejak berabad-abad lalu. Penelitian ini bertujuan untuk mendeskripsikan bahwa mendongeng berbasis kearifan lokal dapat meningkatkan minat baca anak usia sekolah dasar. Pendekatan kegiatan menggunakan jenis penelitian tindakan atau action reseach dengan setting sosial. Penggunaan action reseach dalam kegiatan menghasilkan produk berupa masukan perbaikan yang dapat diterapkan untuk meningkatkan ouput kegiatan. Hasil action reseach menyatakan bahwa materi dongeng jenis fabel cocok disampaikan pada anak yang masih dalam fase kognitif tingkat pre-konvensional. Penokohan binatang dalam dongeng yang diasumsikan dapat berbicara dan berperilaku seperti manusia memudahkan hubungan antara logika dan realita. Perlakuan permainan tradisional dalam mendonngeng mengantarkan suasana semakin menarik dan menyenangkan.
Prediction of temperatures within the depth of asphalt concrete layers and the modeling of temperature-dependent parameters for flexible road pavements design purposes
Authors:   State Enterprise «National Institute of Infrastructure Development» (SE «NIDI»), Kyiv, Ukraine, Tereshchenko Tetyana
Published: November 2024

Introduction. The introduction to the paper highlights the aspects of the analysis of results of flexible road pavement load test which shall be related to the temperature-dependent characteristics of asphalt concrete. Problem statement. The issues of the paper concern the questions of prediction of temperature within the asphalt concrete layer by the BELLS mathematical model and also the adjustment of the flexible pavement’s assessment and design parameters to the reference temperatures. Purpose. The goal of the paper is to analyze the main provisions of the BELLS model and also provisions for modeling the basic temperature-dependent parameters taken into account when designing the flexible road pavements and which are based on the results of the construction stiffness and deflection basin measurements that were performed through the FWD (Falling-Weight Deflectometer) test.
Implementation of automated monitoring systems for bridge structures in Ukraine: World experience and national perspectives
Authors:   State Enterprise «National Institute of Infrastructure Development» (SE «NIDI»), Kyiv, Ukraine, Zavhorodniy Serhii , Redchenko Vasyl ,   State Enterprise «National Institute for Development Іnfrastructure» (SE «NIDI»), Kyiv, Ukraine, 0000-0001-5938-1467 Volodymyr ,   State Enterprise «National Institute for Development Іnfrastructure» (SE «NIDI»), Kyiv, Ukraine
Published: November 2024

ntroduction. Highway bridges are an important element of the transport infrastructure of any country, and Ukraine is no exception. Their safe operation is critical to ensure the sustainable functioning of logistics systems and economic development of regions. However, due to constant loads, the impact of natural factors and insufficient funding for maintenance, a significant number of bridges in Ukraine are in poor technical condition. Accordingly, it is necessary to take measures to diagnose the condition of bridges in a timely manner and prevent possible accidents. In this context, automated condition monitoring systems (ACMS) are an effective tool for ensuring the smooth operation of such structures. Problem Statement. There are more than 16 thousand bridges on public roads of national importance in Ukraine, more than half of which do not meet modern standards for dimensions and load capacity. The problem is particularly acute for bridges that have been in operation for more than 40 years, as they are more prone to accidents. Due to the lack of systematic monitoring and control of the technical condition of such structures, there is a threat of their destruction. In the world practice, automated monitoring systems are actively used to prevent such situations. In Ukraine, the need to implement such systems is becoming increasingly relevant in the face of increased requirements for infrastructure security.
Calculation of the load capacity of an arched road structure fromcorrugated metal by analytical method
Authors:   Academy of Construction and Architecture, Ivano-Frankivsk (at period of martial law), Ukraine, Abramov Volodymyr
Published: November 2024

Introduction. One of the possible options for a simple, practical design of an arched road structure (small bridge) made of corrugated metal is considered, which can be considered as one that is more accurate and labor-intensive for the design of such a structure under the road pressure, as the “structure – soil” system for finite element method. Problem Statement. Regular normative and methodological documents for the design and maintenance of road structures (culverts, small bridges, tunnels) made of corrugated metal provide a simple formula for the structure of the structure and deformation of the body for such structures round pipes. The world is constantly streaming a wider range of rational and fairly simple types of road structures. Purpose. To show one of the possible ways of calculating an arched road structure made of corrugated metal on the basis of generally accepted initial provisions and a simple, understandable calculation scheme is the goal and task of this work.
Pengaruh Kemampuan Literasi Digital dan Media Sosial Instagram Terhadap Perilaku Konsumtif Mahasiswa di Kota Surabaya
Authors: Nur Azizah Farida , Andriansyah Eka Hendi
Published: November 2024

Tujuan penelitian ini yaitu untuk mengetahui bagaimana pengaruh literasi digital dan media sosial instagram terhadap perilaku konsumtif mahasiswa di Kota Surabaya. Penelitian ini menggunakan metode kuantitatif. Jumlah sampel sebesar 347, Sampel penelitian diambil menggunakan teknik Multistage Random Sampling yakni menggunakan purposive sampling dan proportional random sampling. Data akan diolah dan dianalisis menggunakan software SPSS versi 25. Hasil penelitian menunjukkan bahwa secara langsung, literasi digital berpengaruh signifikan dan positif terhadap perilaku konsumtif, Media sosial instagram berpengaruh signifikan dan positif terhadap perilaku konsumtif, serta literasi digital dan media sosial instagram berpengaruh positif secara simultan terhadap perilaku konsumtif mahasiswa.
Comparative Analysis of Using Water Quality in Urban Areas of Duhok City, Iraq
Authors: Mosa Nishtiman Y. , Al-Sulivany Basim. S. A. , Selamoglu Zeliha
Published: November 2024

Water is sourced from various locations, including lakes, wells, artificial reservoirs, and rivers. Contamination of these sources poses a significant threat to human health, highlighting the need to monitor water quality. This study focuses on evaluating the water quality in the Duhok governorate of the Kurdistan region, Iraq, by analyzing several key physicochemical parameters: turbidity, pH, total dissolved solids (TDS), electrical conductivity (EC), total alkalinity (TAL), total hardness (TH), calcium (Ca²⁺), magnesium (Mg²⁺), chloride (Cl⁻), sulfate (SO₄²⁻), nitrate (NO₃⁻), sodium (Na⁺), and potassium (K⁺). Over a period spanning from January 2019 to December 2021, a total of 1,374 water samples were collected from different sources, including reservoirs, deep wells, springs, the Duhok dam, and the water supply network within the Duhok governorate. The analysis revealed that parameters such as turbidity, pH, TH, Ca²⁺, Mg²⁺, SO₄²⁻, NO₃⁻, and Na⁺ varied significantly across the three years studied. In contrast, other parameters like TDS, EC, TAL, Cl⁻, and K⁺ showed no significant fluctuations. The results also indicated a decrease in most physicochemical parameter values in 2021 compared to 2019 and 2020, with the exception of turbidity. Overall, the majority of water samples were found to be within safe drinking limits. Ongoing monitoring of these water sources is essential to detect any variations in water quality promptly.
The Misguided Clash: A Muslim Rebuttal to Huntington’s Civilizational Divide
Authors: Sabeen Hania
Published: November 2024

The Samuel Huntington’s Clash of Civilizations theory represents one side of the coin only, there is a dire necessity to look at this debate of the civilizational clash from the Muslim’s point of view. To analytically explore, how the Clash of Civilizations theory is being perceived and responded by the Muslim societies, particularly through the Constructivist lens of International Relations. The Clash of Civilizations has been a prominent debate in the post-Cold War world in the context of understanding the international relations, yet there always has been a need to identify and fill a critical research gap in grasping the perspective of the Muslim world towards this theory. This gap overlooks the significance of efforts towards cooperation and peace between the Muslim world and the West, further intensifying the misconceptions and aggravating the tensions, leaving room for stereotypes, islamophobia, and inter-civilizational divide. In addition to this, the Huntington’s theory also oversimplifies the notion of diversity existing within the civilization by tagging it as a monolithic entity described solely on religious grounds, in turn, paving way for the ‘us vs them’ divide between the Western and the Muslim world. The qualitative methods approach is employed to collect insightful data on the topic of the misguided clash: A Muslim rebuttal to Huntington’s civilizational divide. This paper is an attempt to explore the Clash of Civilizations theory from the Muslim perspective.
Atypical Presentation of Viral Myocarditis with Isolated Fatigue
Authors: Eldegwy Marwa Said , Elshamy Badr Mahmoud Hassan , Abbas Isra , Saleh Nermeen Awad Alkarim Nurredeen
Published: November 2024

Viral myocarditis is an inflammatory condition of the myocardium, often caused by viral infections. While the typical presentation includes chest pain, shortness of breath, and palpitations, fatigue as the primary symptom is unusual and presents diagnostic challenges. This report presents the case of a 39-year-old healthy male who complained of isolated fatigue and mild chest discomfort after experiencing flu-like symptoms. Initial workup revealed elevated troponin levels with abnormal ECG findings, raising concerns for myocardial involvement. Coronary angiography ruled out obstructive coronary artery disease, confirming the diagnosis of viral myocarditis. The patient responded well to anti-inflammatory and antithrombotic treatment, and no complications were observed during follow-up. This case highlights the importance of considering viral myocarditis in patients with vague symptoms, especially those with recent viral infections, to prevent delayed diagnosis and potential complications. Early identification and treatment are critical to ensure a favorable outcome.
1º Capítulo
Authors: Costa Danilo Vaz Curado Ribeiro de Menezes
Published: November 2024

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2º Capítulo
Authors: Bonetti Marco Antonio , Schneider Marco André , Giraldes Marcus Vinícius
Published: November 2024

Hegel destaca a originalidade de sua categoria de medida, superando Kant e Aristóteles, que não a conceberam em seus sistemas. A medida hegeliana vai além da mera relação quantitativa, sendo fundamental para compreender fenômenos físicos e químicos, diferentemente da visão kantiana da modalidade. O ponto nodal é o momento em que uma mudança quantitativa gera uma mudança qualitativa. Hegel explica que, em determinados pontos, a variação na quantidade de uma coisa (como calor, no caso da água) faz com que ela mude de qualidade, sem interação externa. Por exemplo, a água ao atingir 0°C se transforma em gelo. Esse salto qualitativo não é gradual, mas uma transição brusca, chamada de "salto". A mesma lógica aplica-se a diferentes áreas, como matemática (os números em uma sequência formam relações qualitativas, como múltiplos) e música (harmonias emergem de intervalos específicos entre notas). O sem medida é uma superação dialética da medida. Hegel descreve o "sem medida" como uma forma de infinito dentro da categoria de medida, onde a própria medida perde sua determinação. Ele não implica ausência de medida, mas sim a impossibilidade de mensurá-la em certos casos, como o fenômeno da transformação de estados da matéria (água solidificando ou evaporando). O sem medida representa a ultrapassagem dos limites quantitativos, resultando em uma ruptura qualitativa. Esses conceitos mostram como Hegel vê a realidade como um processo dialético, onde quantidade e qualidade interagem, levando a saltos qualitativos cruciais.
ЭТНОКУЛЬТУРНАЯ ИСТОРИЯ ЧЕЧНИ И ЧЕЧЕНЦЕВ В ИССЛЕДОВАНИЯХ БЕРЖЕ А.П., У. ЛАУДАЕВА
Authors: Алисханова М.Х. , Aliskhanova M.Kh.
Published: November 2024

Статья посвящена этнографическим исследованиям А. П Берже, У. Лаудаева истории и культуры и чеченцев. В статье сделан сравнительный анализ полифонии оценок этнографов в сферах политической истории, исторической географии, этнокультурных процессов Чеч-ни. На основании анализа этнографических исследований А. П. Берже и У. Лаудаева сделаны выводы, что к XIXв. на территории Чечни сложилась в зависимости от природно-географических условий, этнокультурная организация хозяйственной и социальной жизни. Исламизированный этнос, обладал земледельческими районами в плоскостной и равнинной Чечне, труднодоступных горах хозяйственная жизнь была основана на отгонном животно-водстве и террасном земледелии. Исследователи собрали значительный материал о терри-тории, социальной структуре, быте, верований, приданий чеченцев, свидетельствующий о богатом этнокультурном наследии.
Azərbaycanda sığorta bazarının fəaliyyətinin təhlili
Authors:   AEM ( Azerbaijan Science Center ), Məmmədov Orxan
Published: November 2024

Xülasə Maliyyə sisteminin tərkib hissəsi olan sığorta – bir iqtisadi kateqoriya olaraq, baş verən bu və ya digər xoşagəlməz hallardan, fövqəladə hadisələrdən vurulan ziyanın aradan qaldırılması, vətən­daşların şəxsi həyatları ilə əlaqədar olan hadisələr zamanı onlara maliyyə yardımlarının edilməsi ilə yaradılan məqsədli pul vəsaiti fondlarının yaradılması və istifadəsi prosesidir. Sığorta işinin səmərəli təşкilinin və bеynəlхаlq stаndаrtlаr səviyyəsində inкişаf еtdirilməsinin ölkə iqtisаdiy­yаtının bаzаr münаsibətləri şərаitində möhkəmlənməsində mühüm iqtisаdi əhəmiyyəti vаrdır. Bu baxımından sığorta fəaliyyətinin həyata keçirilməsində daim nəzarət mövcuddur. Sığorta bazarında fəaliyyət göstərən şirkətlərin fəaliyyətinin qiymətləndirilməsi mütəmadi olaraq dövlətin nəzarətin­dədir və bu yoxlamanının həyata keçirilməsi birbaşa olaraq Mərkəzi Banka həvalə edilmişdir. Respublikamızın müasir sığortası, maliyyə sisteminin ən önəmli sferalarından biridir. O, istehsalının aşağı düşməsinin qarşısının alınmasında, onun fasiləsizliyinə zəmanət yaradılmasında şübhəsiz əhəmiyyətə malikdir. Sığorta bazarının izlənməsi, orada baş verən hadisə və proseslərin müsbət və ya mənfi dinamikası statistikasız ötüşmür. Bütövlükdə sığorta bazarı və burada əhaliyə göstərilən sığorta xitmətlərinin səviyyə və dinamikasının statistik öyrənilməsi və qiymətləndirilməsi bütün dövrlərdə aktul bir mövzudur.
Реакционные и положительные стороны романтиков
Authors:   AEM ( Azerbaijan Science Center ), Муслимова Офеля
Published: November 2024

Резюме Как отмечает автор, вожделенный новый мир принес жесточайшие разочарования: надежды на царство разума остались неоправданными, идеалы не стали реальностью; Возникшее недовольство отразилось не только на новом образе жизни, но и на идеологии просвещения. Что же касается прогрессивных и консервативных романтиков, то их идеалы оставались утопией, поскольку еще не наступило или уже прошло время, когда они могли быть реализованы. Сегодня важны лишь те романтические произведения, которые служили человечеству, оказали положительное влияние на развитие человеческого духа и литературы или содержали эстетические ценности. Он искренне верит в победу справедливости и полон уверенности; Он хочет защитить отверженных и бесправных, штурмовать мир и судьбу или погибнуть в бунте. По мнению автора, романтики не только первыми осознали отчуждение и проиллюстрировали его в своих произведениях, но и попытались его преодолеть. Народная привлекательность романтиков имели большое значение для их художественного творчества и развития литературы в целом. Историзм романтиков заключался в улавливании истори­ческих и национальных особенностей культуры и искусства разных времен и народов. Хотя они имели лишь весьма смутное представление о процессе исторического развития и понятие истории еще представлялось им в элементарной форме сравнения, историзм имел еще большое значение для литературы, поскольку связывал теорию искусства с историей. Вместо мифологических сюжетов у классиков появились конкретные исторические образы. Романтики создали множество эстетических ценностей и идеалов, которые актуальны и сегодня и стали органической частью социалистического реализма.
Phraseologisms as an object of Linguistic Research
Authors:   AEM ( Azerbaijan Science Center ), Pashayeva Sanam
Published: November 2024

Abstract This article examines phraseological units that reflect the national and cultural identity of the English people. The relevance of the work is related to the endless interest of modern linguists in the problem of the relationship between the language and culture of the people, in studying the problems of national-cultural specificity of phraseological units. The phraseological units of the English language are an image that reflects the uniqueness of the life of the English people in the process of development as a separate nation. The purpose of the article is to show the relationship of phraseological units with the national character of the English and to show how phraseological units reflect the national mentality of the English people. In order to achieve the goal of this work, the following tasks have been set: - to study the theoretical opinions of linguists on the topic of phraseology; - to identify the phraseological units of the English language with national-cultural shades; - to analyze the phraseological units identified during the research.
Rhizosphere Bacteria
Authors:   AEM ( Azerbaijan Science Center ), Abdullayeva Shahla
Published: November 2024

Abstract The review is devoted to the analysis of modern literature data on rhizosphere bacteria and their role in the vital activity of plants. The structure of the rhizosphere is characterized, the role of plants as centers of formation of microbial communities is shown, data on the taxonomic affiliation of the main groups of microorganisms inhabiting the rhizosphere are presented. The associative relationships of rhizobacteria with a partner plant and the modern concept of a holobiont as a combination of a plant organism and associated microorganisms are considered. The role of rhizobacteria in the processes of azo fixation is discussed in detail. The mechanisms of direct stimulation of plant growth through the synthesis of phytohormones, improvement of phosphorus and nitrogen nutrition and increase in stress resistance, as well as indirect stimulation through antagonism with respect to phytopathogenic microorganisms are presented. The criteria for the selection of rhizobacteria for practical purposes are discussed.
Цифровые платформы в условиях приоритетности использования интеллектуального капитала
Authors:   AEM ( Azerbaijan Science Center ), Аббасов Теймур
Published: November 2024

Резюме В научной статье говорится о приоритетности использования интеллектуального капи­та­ла, являющегося необходимостью обеспечения конкурентоспособности инноваци­онной, в том числе цифровой, инновационной деятельности. Подчеркивается, что цифровые иннова­ции в настоящее время являются важным направлением инновационного развития. В статье указывается, что как и в любой совокупности экономических отношений и про­цессов, возможности и результаты в цифровой экономике должны подвергаться сравни­тельной оценке, а для этого они должны быть количественно измеримыми. Также в статье подчеркивается мысль о том, что растущая роль цифровых платформ в контексте приори­тетного использования интеллектуального капитала не оставляет без внимания экономику знаний. Исследования показывают, что совершенствование цифровых платформ играет ре­шающую роль в развитии экономики знаний. В конце автор приходит к выводу о том, что о требованиях, выдвигающихся к цифровым платформам интеллектуального капитала даже в ближайшем будущем, можно пока только предполагать.
Seeing the Futures: Evaluating the Application of Structured Analytic Technique Alternative Futures Analysis
Authors: McCarthy Loren
Published: November 2024

The Structured Analytic Technique (SAT) Alternative Futures Analysis (AFA) is an imaginative thinking technique used by intelligence analysts in circumstances of uncertainty to generate and explore a range of potential future states. Recent literature on SATs has been critical of their use because of an absence of robust evidence of their value. This research observed focus groups which applied AFA to a specific case study and evaluated their outputs. The results suggest AFA can be used less prescriptively than some of the literature sets out in terms of group size and timeframe, while also supporting the recommended use of a facilitator. An understanding of the purpose of AFA as an imaginative thinking technique, intended to explore future possibilities, is vital in applying the technique, evaluating it, and communicating the results. The potential for mismatch between the criteria suggested to analyse SATs in general and the intent of AFA as a technique, undervalues the technique. A key consideration in evaluating AFA, is the need to ensure the technique is applied as intended. Further, this research identifies that the learning context may influence the application of AFA.
The influence of social media portrayal on the self-presentation of women in the digital era
Authors: Velez Don Antonio , Pastrano Louisse Gertrude Adis
Published: November 2024

Social media serves as a powerful force in shaping societal norms and values, often presenting idealized and unrealistic images of womanhood. This study explores how social media influences women's gender roles and identities, particularly its impact on their aspirations and self-esteem, while also providing opportunities for self-expression and empowerment. Using a phenomenological approach, the research involved focus group discussions with young women aged 18–25 living in Cagayan de Oro City, Mindanao, Philippines. The findings reveal that women respond differently to social media content based on their values, beliefs, and backgrounds. The results highlight social media's dual impact: it can both reinforce traditional gender norms and serve as a tool for self-empowerment. This complexity demonstrates the need to recognize individual differences in social media engagement and their effects on shaping gender identities. By exploring these diverse interactions, the study contributes to a deeper understanding of the multifaceted relationship between social media and gender role formation.
Beyond the gut: Exploring neurological manifestations in inflammatory bowel disease
Authors: Goyal Manjeet Kumar , Kalra Shivam , Rao Abhinav , Khubber Manisha , Gupta Abhinav , Vuthaluru Ashita Rukmini
Published: November 2024

Neurological manifestations in inflammatory bowel diseases (IBD), such as Crohn’s disease and ulcerative colitis, are increasingly recognized as significant contributors to both disease burden and patient morbidity. This comprehensive review delves into the spectrum of neurological complications linked with IBD, highlighting the involvement of both the central and peripheral nervous systems. The neurological impairments range from more common conditions such as peripheral neuropathy, characterized by nerve damage leading to pain and numbness, and cerebrovascular diseases, which include strokes and transient ischemic attacks, to less frequent but intensely severe conditions such as multiple sclerosis and myasthenia gravis, which involve the immune system attacking components of the nervous system. The complex pathophysiology underlying these manifestations integrates various factors including immune-mediated responses, vascular abnormalities such as thromboembolism, nutritional deficiencies often exacerbated by malabsorption and chronic inflammation, and the adverse effects elicited by IBD medications such as corticosteroids and immunomodulators. This review underscores the importance of adopting a multidisciplinary management approach. By integrating the expertise of gastroenterologists with that of neurologists, rheumatologists, and other specialists, patient outcomes can be significantly optimized. Further emphasis is placed on the necessity for heightened clinical awareness and the implementation of early diagnostic interventions to effectively identify and mitigate the neurological complications associated with IBD. In conclusion, ongoing research aimed at elucidating the underlying mechanisms that connect IBD with neurological disorders is imperative to facilitate the development of more effective preventative and therapeutic strategies for these challenging complications.
Pediatric drug regulations: A global perspective and the imperative for implementation in India
Authors: Tatar Mangesh , Jadhav Swati , Wadhava Lisha , Upaganlawar Aman , Upasani Chandrashekhar
Published: November 2024

The pediatric population differs from adults in various ways, including physiological factors, pharmacokinetics, pharmacodynamics, and dosage administration. However, many medications prescribed for children are formulated for adults, necessitating dose adjustments throughout childhood. This underscores the need for pediatric drug formulations and regulations worldwide. This review delves into the intricate landscape of international pediatric drug regulations to elucidate key initiatives, challenges, and advancements shaping this field. Commencing with a historical backdrop, the review outlines the evolution of regulatory frameworks across major regions, including the United States (US), Europe, Japan, and China, while underscoring the imperative for the implementation of pediatric drug regulations in India. These regulations mandate age-appropriate dosing, rigorous clinical trials, and thorough labeling to prevent misuse. They require pediatric-specific studies to understand drug effects and dosages and enforce guidelines for off-label use. Agencies such as the US Food and Drug Administration oversee these regulations, ensuring pediatric drugs meet safety standards before approval. In addition, regulations often include provisions for informed consent and parental involvement in treatment decisions, aiming to protect children from adverse effects while providing effective therapeutic options tailored to their developmental needs. In summary, this review emphasizes the importance of global cooperation and harmonized regulations in advancing pediatric drug research. It highlights recent progress while acknowledging ongoing challenges and opportunities in this critical area.
Peroxisome proliferator-activated receptor agonists as an adjuvant for cancer therapy: A review
Authors: Patel Binita , Kaid Johar S. R.
Published: November 2024

Cancer is now one of the leading diseases responsible for the highest mortality rates worldwide. Cancer treatment is extremely intricate and is often associated with less targeted effects and more side effects. In the last few years, two significant revolutions in cancer treatment have altered treatment paradigms: immuno-oncology and the pursuit of actionable changes in oncogene-driven cancers. Significant obstacles continue to exist in both areas of cancer treatment. Next-generation sequencing technologies for molecular prescreening in clinical research are advancing, but their widespread clinical use is hindered by challenges related to the clinical interpretation of large genomic data. Moreover, cancer mono-chemotherapy is associated with issues such as inadequate efficacy, drug resistance, and systemic toxicity. It is not possible to administer cytotoxic drugs limitlessly. Combination therapy was developed in response to this circumstance, with the expectation of achieving high therapeutic efficacy at lower dosages of medication. Peroxisome proliferator-activated receptors (PPARs) are a group of essential lipid sensors and metabolic pathway regulators. In addition, they possess the ability to modulate immunity, inflammation, and endothelial nitric oxide synthase activation. Alongside their well-established functions, new insights into the roles of PPAR agonists in cancer research are emerging. After reviewing current research, it is evident that PPAR modulators have significant potential for managing cancer. This review aims to consolidate the functions of PPAR ligands alongside other cancer therapies. We provide a comprehensive perspective on the applicability of PPAR ligands in cancer treatment as an adjuvant.
A New Model to Correlate Solubility of Therapeutic Drugs in Supercritical Carbon Dioxide
Authors: Amrithaa Raghavan , Garlapati Chandrasekhar
Published: November 2024

In this work, a new solubility model was proposed based on the enhancement factor concept. The proposed model is validated with the literature available solubility data of seventeen therapeutic drugs in supercritical carbon dioxide. The correlating ability of the proposed model was compared with the Chrastil model and Bartle et al. model. The global average absolute relative deviation (AARD) percentages of Chrastil, Bartle et al. and new models were 19.42%, 19.57% and 16.43%, respectively. Sublimation enthalpies of therapeutic drugs were calculated with a new model as well as with Bartle et al. model. The calculated sublimation enthalpies ranged between 8.32 to 180.23 kJ/mol and 19.5 to 280.26 kJ/mol for the Bartle et al. model and the Improved Bartle model, respectively. Finally, a statistical analysis was performed in terms of Alaike's Information Criterion (AIC) to differentiate models considered in this work.
Thermal Decomposition of Pure Waste and Binary Mixtures
Authors: Thalyne de Almeida Ferreira Rocha  , Guilherme Henrique Alves Pinto  , Maria do Carmo Ferreira  , Jose Teixeira Freire  , Fábio Bentes Freire
Published: November 2024

In this study, the thermal decomposition of pure organic residues - coffee grounds, sugarcane bagasse and orange juice residues - and their binary mixtures with coffee grounds were analyzed. The results of thermogravimetric analyses at 10 °C/min under an oxidizing atmosphere showed that sugarcane bagasse and coffee grounds had individually higher reaction rates in the devolatilization zone, while orange juice residues burned more quickly in the combustion zone. There were significant mass interactions between the coffee grounds and orange juice residues in the binary mixtures, which led to higher reaction rates in the combustion of the mixture than in the pure residues. In the mixture of coffee grounds and sugarcane bagasse, there were no significant mass interactions. These encouraging findings can optimize the generation of bioenergy from these wastes and their mixtures, therefore, one must understand the different interactions during thermal decomposition to then develop sustainable strategies for utilizing biomass.
Quantitative Structure-Property Relationship of the Rare-Earth Elements-Dibutyl Dithiophosphate Derivative Complexes Using Principal Component Analysis
Authors: Nurdeni  , Saputra Heru Agung , Atje Setiawan Abdullah  , Budi Nurani Ruchjana  , Husein Hernandi Bahti  , Hedi
Published: November 2024

The separation of rare-earth elements (REEs) has increasingly developed, especially using a complexing ligand of dibutyl dithiophosphate (DBDTP) that has numerous advantages as an extractant in the extraction process. Through technology development, this separation utilizes computational chemistry design to scheme the DBDTP ligand and its derivatives. One of the computational chemistry applications is a quantitative structure-property relationship (QSPR), which is useful for designing ligand derivatives by calculating molecular descriptors and connecting molecular structure with its physicochemical properties. In the present study, we aimed to get a dominant factor affecting complex stability formed from the REEs with DBDTP ligands and the REEs with DBDTP derivative ligands using principal component analysis for the QSPR study. The analysis results demonstrated that the stability of gadolinium, terbium, and dysprosium complex compounds was influenced by seven, seven, and six factors with a total variance of 93.93, 93.17, and 91.63%, respectively.
Heavy Metal Pollution Studies of Soil from the Oti-Dompoase Dumpsite in Kumasi
Authors: Nkansah Marian Asantewah , Kofi Adzibolosu Anthony Seyram , Kumah Moses Ernest , Bennin Ernest , Adrewie Dominic
Published: November 2024

Waste disposal sites contribute a great deal to environmental pollution. The degree of pollution brought on by heavy metal contamination of soil collected from the Oti-Dompoase dump site in Kumasi of Ashanti region, Ghana was investigated in this study. Twelve (12) composite samples of the surface soil were taken in total at 10 cm depth from the dumpsite to conduct metal analysis. The measurement of heavy metal concentration was done utilizing Atomic Absorption Spectrometer, which uses the absorbance at various wavelength of the electromagnetic spectrum to determine the chemical identity of constituents of the sample and their concentrations with the help of standard solutions and Beer-Lambert law. The mean metal concentrations of soil samples were reported and arranged in terms of magnitude as follows: Iron (2,582.21 mg/kg) > Copper (348.50 mg/kg) > Lead (324.85 mg/kg) > Manganese (192.27 mg/kg) > Zinc (146.24 mg/kg) > Cadmium (7.06 mg/kg). Physiochemical properties such as electrical conductivity (EC), pH and organic matter and water content (%) were also investigated using a PHYWE electrical conductivity meter, pH meter and an oven, respectively. Most of the parameters analysed indicated pollution when compared to baseline values, while human exposure levels were within World Health Organization (WHO) standards. Assessments using geo-statistics of different hazard indicators, including pollution load index, contamination factor (CF), and geo-accumulation, all point to heavy metal pollution of the soil samples. Cadmium contamination was very high based on the pollution indices (CF, geo-accumulation, and pollution load) and manganese has the lowest level of pollution. There is limited data on the extent of pollution caused by the Oti-Dompoase dumpsite and this study will serve to fill this knowledge gap and contribute to the Millenium Development Goal seven (7) by providing data on the extent of pollution of soil around the Oti-Dompoase dumpsite and highlight the need for regular monitoring and on-site remediation strategies to safeguard the site to ensure environmental sustainability.
Preparation of Value-added Chemicals via Chemical Looping Pyrolysis of Corn Straws with Ca-Fe Composite Oxygen Carrier
Authors: Li Wenyao , Zhao Longxin , He Xiao , Liu Jingjing , Liu Yongzhuo , Guo Qingjie
Published: November 2024

Biomass chemical looping pyrolysis (BCLPy), which utilizes either reduced or oxidized oxygen carriers for biomass pyrolysis, enables the simultaneous production of high-quality bio-oils and clean syngas. In this study, CLPy of corn straws with a Ca-Fe composite oxygen carrier was investigated to produce value-added chemicals by optimizing both temperature and the mass ratio of oxygen carrier to biomass (OC/B). It has been demonstrated that the reduced Ca-Fe oxygen carrier (Re-OC) promotes hydrocarbon formation and facilitates removal of oxygenated compounds from bio-oils. Under optimal conditions (Re-OC/B = 4:3, T = 650 °C), the relative percentage of benzene, toluene and xylene (BTX) in the bio-oil reaches 27.0 area%, while that of 2-pentenone accounts for 38.0 area% at 550 °C with a Re-OC/B mass ratio of 1:3. The maximum yield based on corn straws approaches 4.7 wt.%. Regarding the oxidized Ca-Fe oxygen carrier (Ox-OC), the relative percentage of 2,3-dihydrobenzofuran (2,3-DHB) reaches a maximum value of 11.6 area% at 600 °C with an Ox-OC/B mass ratio of 2:3. Under catalytic ketonization of Ca2Fe2O5 oxygen carrier, a maximum value of 28.0 area% is achieved with an Ox-OC/B mass ratio of 4:3 at 450 °C. In summary, BCLPy provides a completely new strategy for producing biomass-derived chemicals with added value.
Antioxidant Potential and Phytochemical Screening of Extracts from Senegalia nigrescens-A Traditional Swazi Medicinal Plant
Authors: Pillai Manoharan Karuppiah , Siwela Samkelisiwe Nokuphila
Published: November 2024

Senegalia nigrescens has been used in traditional Swazi medicine. S. nigrescens is used in the treatment of wounds, toothache, diabetes, dysentery, snake bites, convulsions and skin diseases. In this study, we aimed to evaluate the antioxidant potential, determine the half-minimal inhibition concentration (IC50) values and analyze phytochemical constituents of various solvent extracts obtained from the leaves and stem-bark of S. nigrescens. The maceration technique together with the hot solvent extraction approach was used for the obtainment of various solvent extracts. 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging potential, IC50 values and phytochemical analysis were performed as per established procedures. The radical scavenging potential of extracts from leaves and stem-bark of S. nigrescens and positive control (ascorbic acid) were found to be in the ranges of 7.55 ± 0.004 ~ 62.19 ± 0.004%, 9.04 ± 0.003 ~ 63.24 ± 0.006% and 50.98 ± 0.002 ~ 71.0 ± 0.007%, respectively at a concentration range of 200 ~ 3,000 μg/mL. The methanol extracts from the leaves, stem-bark and positive control exhibited IC50 values of 921.69, 735.74 and < 200 μg/mL, respectively. Several classes of phytochemicals were identified in these extracts which include alkaloids, steroids, terpenoids, flavonoids, phenolics and tannins. We concluded that S. nigrescens showed a weak to moderate DPPH radical scavenging potential and possessed various classes of phytochemicals.
Existential Verse-Capping between a Female Troll and the Poet Bragi
Authors: Sayers William
Published: November 2024

Abstract Two formally similar stanzas of verbal contention between a troll woman and the poet Bragi Boddason display auto-definitions, one of a paranormal being antagonistic toward, and destructive of, human life, another of a creator of order and its pre-eminent expression,
skaldic verse. In the irony so often deployed in Old Norse-Icelandic literature, the troll, the initiator of the contest, uses what is, for her, the antithetical medium of verbal art to proclaim her attack on it. Bragi replies in more straightforward manner and seems to be the immediate winner
of the contest, since he is allowed the last word. In this, the poet’s craft may forestall Ragnark, the epitome of the troll’s objectives of chaos. The contest has affinities with the senna, flyting, and less formal exchanges of defamatory verse. It could have originated
in an aristocratic patron’s challenge to a court poet or poets to devise such a pair of stanzas, his challenge then evoking the greater existential challenge of these representatives of differing orders of being. The stanzas, in multiple and varied ways, celebrate the social value of
the poet, the art of skaldic verse, and its capacity to preserve cultural history against oblivion.
Das Erfurter Marienstift und das Licht: Eine Rekonstruktion künstlicher Beleuchtung in und an der mittelalterlichen Stifts- und Pfarrkirche St. Marien
Authors: Henkelmann Vera , Bornschein Falko
Published: November 2024

Die ehemalige Erfurter Stifts- und Pfarrkirche St. Marien nahm in Erfurt selbst wie in der Region einen besonderen Rang ein. Sie war nicht nur Hauptkirche der Stadt, sondern der Propst des Erfurter Marienstifts war zugleich einer der Archidiakone, der zusammen mit den Kanonikern des
Stifts den Ostteil der Mainzer Diözese in Thüringen einschließlich der Stadt Erfurt verwaltete und die Interessen des Mainzer Erzbischofs in weiten Teilen Thüringens vertrat.1 Wie andernorts sollten Lichtgerät, Lichtregie und Lichtinszenierung wie die übrige
Ausstattung die Bedeutung der Kirche unterstreichen und zu einer angemessenen Repräsentation und Selbstvergewisserung des Erfurter Marienstifts beitragen.2 Auch in Erfurt diente also das Licht nicht allein praktischen Belangen wie der Wegebeleuchtung und Ausleuchtung des Altarbereichs.
Vielmehr trug es zur Inszenierung des Kirchenraumes bei, kennzeichnete ihn als Sakralraum und unterstrich den Festcharakter der Liturgie, war Licht ja Sinnbild göttlicher Präsenz.3
,,zů gedechtnisse irer selen“. : Strategien zur Sicherung des Seelenheils in den spätmittelalterlichen Testamenten aus Worms
Authors: Wagner Sophia
Published: November 2024

Abstract Hardly any other genre of sources provides historians with as much information about the medieval contemporaries’ concept of the afterlife as wills. At the intersection of material and spiritual concerns, the testators had to make elementary decisions for their
relatives’ financial support, as well as their own pursuit of salvation. The late medieval testamentary tradition in the city of Worms shows that the testators applied quite individual strategies in the distribution of their goods in the area of tension between the need for provision
of their own families and the endowment of the clergy. The law of inheritance offered a certain degree of tolerance for the testators’ own decisions. The specific distribution of goods to trustworthy persons and (spiritual) institutions, allowed the creation of an individual and self-determined
memoria. Furthermore, legal instruments, such as the revocation of earlier wills, the designation of successor beneficiaries of endowments, or the threat of penalties in the case of incorrect execution of the last will, allowed the drafters to secure their arrangements even for the
time after their own death.
Gillian Adler and Paul Strohm, Alle Thyng Hath Tyme: Time and Medieval Life. London: Reaktion Books, 2023, 247 pp., 51 color images.
Authors: Oberlin Adam
Published: November 2024

In eight chapters the authors have compiled a wide-ranging popular scholarly work of a particularly common type – informative and generally broad, occasionally strangely narrow, but primarily sufficient for the task of introducing readers to a foundational topic in Medieval Studies.
The chapters discuss Varieties of Time, Measuring Time, Time and the Planets, Lives in Time, Timescapes: Narrative Shapes of Time, Allegories of Time, Ages of Humankind, and The End of Time. As one might guess from the title, the focus lies principally on Middle English with frequent recourse
to Dante, occasional French literature, and various Latin sources such as the Legenda aurea and the Rule of St. Benedict, and the period under investigation is accordingly the later Middle Ages, corresponding to the introduction of mechanical clocks, though the narrative often
jumps from the classical or early medieval period to the fourteenth century in England.
Min sang sol wesen dîn: Deutsche Lyrik des Mittelalters und der frühen Neuzeit. Interpretationen. Hrsg. von Tobias Bulang, Holger Runow und Julia Zimmermann. Wiesbaden: Reichert Verlag, 2023, 295 S.
Authors: Classen Albrecht
Published: November 2024

Während wir uns in der akademischen Lehre notgedrungen meist auf die ‘klassischen’ Werke mhd. Lyriker konzentrieren, obliegt es doch der Forschung, immer wieder neue Wege einzuschlagen, auch unbekanntere Texte in die Betrachtung einzubeziehen und damit innovative Perspektiven
zu entwickeln. Ad fontes auch in dieser Hinsicht. Das Corpus mhd. Lyrik ist sehr umfassend, und wissenschaftlich gesehen gibt es da ungemein viele weiße Flecken auf der mentalen Landkarte. Der vorliegende Band will hier neue Schneisen schlagen, indem einzelne Texte herausgegriffen
und sorgfältig untersucht werden, ohne dass ein systematischer Zugriff verfolgt würde. Vielmehr hat sich eine Schar von Forschern (Schülern) zusammengetan, die zu einer oder anderen Gelegenheit im Seminar bei Frau Prof. Dr. Beate Kellner gesessen haben und gemeinsam mit ihr
sich darin übten, mhd. Lyrik so genau wie möglich anhand der Texte und des kulturhistorischen Kontexts neue Erkenntnisse zu gewinnen. Der Band ist also sogar eine Festschrift anlässlich ihres 60. Geburtstags, was die relative Beliebigkeit der Beiträge und auch die etwas
ungenaue Betitelung des Buches erklärt (am Ende gibt es beachtenswerterweise eine Arbeit bezogen auf französische Literatur des 16. Jahrhunderts. Die drei Herausgeber bedauern, dass sie hier nicht auf die Unterstützung durch Kellner zurückgreifen konnten, aber man merkt
durchweg, wie solide alle Aufsätze doch gestaltet sind und mehr oder weniger einen guten Beitrag zur einschlägigen Forschung leisten.
Murasaki Shikibu, The Tale of Genji. Trans. and abridged by Dennis Washburn. The Norton Library. New York: W. W. Norton, 2022 (2015), xxvi, 821 pp.
Authors: Classen Albrecht
Published: November 2024

As Edward Kamens claims in his article on The Tale of Genji in the Companion to World Literature, ed. Ken Seigneurie, vol. 2, ed. Chrstine Chism (2020), “If the ‘Azumaya’ tale-reading scene is indeed a microcosm and prototype of the monogatari
of its mode of performance, the ‘Hahakigi’ ‘rainy night conversation’ is a generating turbine that not only propels Genji (and his progeny) out into the world of love and loss but which also throws out a seemingly limitless current of energy for storymaking and storytelling,
giving rise and giving life to the many tales and tales-within-tales that follow in what are, for us, now, the pages of The Tale of Genji . . .” (1083–84).
Kevin Renner, Konzeptionen von Philosophie im 12. Jahrhundert: Zum Begriff der Philosophie bei Hugo von St. Viktor und Dominicus Gundissalinus in ihren Werken Didascalicon und De Divisione Philosophiae. Beiträge zur Geschichte der Philosophie und Theologie des Mittelalters,
Neue Folge, 9. Münster: Aschendorff Verlag, 2023, X, 311 S.
Authors: Classen Albrecht
Published: November 2024

Wie ja gut bekannt entwickelte sich im langen 12. Jahrhundert ein neues Phänomen, das wir als ‘Renaissance’ bezeichnen, die lange vor der Italienischen Renaissance auftrat und tiefgreifende Folgen für die gesamten Wissenschaften einschließlich der Theologie,
für die Architektur, Literatur, Medizin und Naturkunde mit sich führte. Die Aristoteles-Rezeption und der umfangreiche Übersetzungsprozess von arabischen Texten über das Hebräische ins Lateinische sowohl in Salerno als auch in Toledo hatten eine große Wirkung.
Wie nun Kevin Renner in seiner für den Druck aufbereiteten Regensburger Dissertation vom WS 2019/2020 eindringlich vor Augen führt, kam es auch in der Philosophie und Theologie zu einem grundlegenden Wandel, denn die artes liberales, vor allem das Quadrivium, gewannen Eigenkraft
und Selbständigkeit, was wiederum dazu führte, dass auch die Philosophie neuartig gesehen wurde.
Steven Rozenski, Wisdom’s Journey: Continental Mysticism and Popular Devotion in England, 1350–1650. Notre Dame, IN: University of Notre Dame Press, 2022, 330 pp., 7 b/w ill.
Authors: Burke Linda
Published: November 2024

What type of literary text was most popular with English-language readers in the late Middle Ages and well into the early modern era? To judge from the number of surviving manuscripts and early print editions, the answer is, didactic works, including guidebooks to devotion, the focus
of this important new study. Up to now, as explained by Steven Rozenski, this enormous class of works has been relatively neglected in the scholarship and teaching of medieval English literature in favor of genres more congenial to contemporary taste, such as the secular romance (1).