bluuebunny/crossref_metadata_2025 huggingface dataset:
Revisão de estudos que empregaram intervenções afirmativas para LGBTQI+ sob uma perspectiva analítico-comportamental
Authors: Mussi Samir Vidal , Malerbi Fani Eta Korn
Published: April 2022

A terapia afirmativa é voltada para a população LGBTQI+. O objetivo deste artigo foi rever, sob a perspectiva da Análise do Comportamento, estudos que empregaram a terapia afirmativa. Foram realizadas buscas nos portais CAPES, PubMed, LILACS, PsicINFO, SciELO e MEDLINE. Foram selecionados oito estudos de revisão e sete estudos empíricos. Verificou-se que os estudos se basearam em abordagens teóricas variadas, sendo que quatro alicerçaram-se no modelo cognitivo-comportamental. Todos os estudos empíricos avaliaram o autorrelato dos participantes e as principais intervenções consistiram em organizar um ambiente de terapia não punitivo e asseguraram que o terapeuta funcionasse como uma audiência reforçadora, procurando ajudar o indivíduo a identificar as contingências aversivas associadas com os comportamentos diferentes dos esperados para o seu sexo biológico, instrumentalizá-lo a modificar tais contingências, incentivá-lo a descrever seus pensamentos e estados afetivos associados à condição de pertencer à população LGBTQI+ e encorajá-lo a participar de grupos de apoio.
Análise da Restrição de resposta no procedimento go/no-go com estímulos compostos em crianças com autismo
Authors: Silva Rafael Augusto , Debert Paula
Published: April 2022

Estudos que tiveram sucesso no treino de relações condicionais com crianças com autismo por meio do go/no-go com estímulos compostos utilizaram um procedimento chamado Restrição de resposta (RR). Uma vez que a RR foi utilizada desde a primeira tentativa, não foi possível avaliar seus efeitos no responder dos participantes. O presente estudo realizou uma análise de resultados anteriormente publicados afim de avaliar se um padrão de responder diante de todos os compostos, comum em crianças com autismo, ocorreu com os participantes quando a RR foi inicialmente removida. Os resultados demonstraram que durante a remoção da RR, ocorreu um aumento abrupto de respostas para a maioria dos participantes. Após a reintrodução e posterior remoção da RR os participantes adquiriram as relações condicionais. Dados de mais dois novos participantes replicaram esses resultados. A RR parece ser fundamental para estabelecer um responder discriminado com essa população com o go/no-go com estímulos compostos.
Desenvolvendo comportamentos próssociais em crianças através de tootles e do trabalho preventivo em rede
Authors: Calegari Thiago Wisniewski , Pessôa Candido Vinicius Bocaiuva Barnsley , Kovac Roberta
Published: April 2022

Este estudo avaliou os efeitos de um projeto gamificado utilizando tootles sobre a incidência e prevalência de comportamentos pró e antissociais em duas turmas de crianças de uma escola pública. Crianças e professoras foram encorajadas a escrever tootles e colá-los em um mural de acordo com os desafios apresentados. Cada tootle resultava em 1 ponto para a turma. Se crianças e professoras alcançassem a quantidade mínima de tootles durante cada desafio, outros setores da cidade organizavam atividades recreativas às crianças como forma de comemoração. Observações diretas do comportamento de oito crianças foram conduzidas diariamente. Os resultados mostraram aumentos na incidência e prevalência de comportamentos próssociais em ambas as turmas, com efeito mais pronunciado na Turma A. Comportamentos antissociais permaneceram estáveis e próximos a zero. Outros exemplos de comportamento próssocial foram relatados além daqueles inicialmente previstos. Por fim, as professoras avaliaram o projeto positivamente. Limitações e recomendações para replicações são então discutidas.
A discreta introdução do behaviorismo no português brasileiro: A tradução de “Psychological Care of Infant and Child” de Watson e Watson
Authors: Paixão Aline Aparecida , Strapasson Bruno Angelo
Published: April 2022

O Psychological Care of Infant and Child (Watson & Watson, 1928) foi o primeiro livro de Behaviorismo traduzido para o português brasileiro, publicado no país em 1934 e em 1941. Neste artigo apresentamos uma análise histórica do contexto do surgimento dessa tradução bem como algumas características do texto traduzido. Condições sociais responsáveis pelo desenvolvimento da puericultura, mudanças no mercado editorial brasileiros derivadas da crise de 1929 e o estabelecimento de uma cultura de educação de pais parecem ter promovido o investimento na tradução do livro e sua divulgação no país. Apesar dessa tradução ocupar uma posição privilegiada para a disseminação do Behaviorismo no Brasil, problemas na tradução e eventuais avaliações críticas do autor do prefácio e das notas de tradução parecem ter entregado um livro menos behaviorista que seu original, comprometendo seu potencial para disseminação do behaviorismo.
História e ensino da análise do comportamento na Bahia: da criação do laboratório experimental à formação dos primeiros analistas do comportamento da FFCH/UFBA (1968/1980)
Authors: Silva Rosane Maria Souza
Published: April 2022

O objetivo é descrever e analisar o processo de implantação do laboratório experimental e a formação dos primeiros analistas do comportamento do curso de psicologia da FFCH/UFBA. São apresentados os marcos iniciais da Análise do Comportamento no Brasil; o processo de criação do laboratório do curso de psicologia FFCH/UFBA; e a formação dos primeiros analistas do comportamento em Salvador, entre os anos de 1968 a 1980. Adota-se a perspectiva dos Estudos Sociais das Ciências e da História Crítica da Psicologia. As fontes primárias, acessadas nos arquivos da UFBA foram: atas, pareceres, cartas, ofícios, programas de curso, planos de aulas e relatórios. Verificou-se que o laboratório de psicologia experimental se estruturou a partir do suporte teórico-técnico dos psicólogos da AEC da USP e que a recepção à AEC no curso da UFBA atendeu às demandas de ensino e formação docente e discente no contexto acadêmico baiano, no período analisado.
Breve histórico das práticas experimentais no laboratório didático: percalços e inovações
Authors: Gotti Eduardo Sousa , Gabriel Ferreira Argondizzi João , Adriana de Oliveira Elimar , Ian Siqueira Dérick , Fernandes Ormelesi Marcelo
Published: April 2022

O presente artigo expõe sobre os eventos que contribuíram para o desenvolvimento da Análise do Comportamento no Brasil e que influenciaram no ensino experimental desta ciência. Aponta sobre os modelos experimentais utilizados no contexto do laboratório didático, e sobre a busca por alternativas ao tradicional ensino no laboratório animal e os seus determinantes históricos. Por fim, destaca sobre a importância e urgência do desenvolvimento de práticas alternativas no laboratório didático.
Avaliação da eficácia de um manual de autoinstrução para aplicação de procedimento de ensino em tentativas discretas (DTT): um estudo com estudantes universitários
Authors: Freitas Luiz Alexandre Barbosa , Silva Andressa Muniz , Pinheiro Mylena Gonçalves , Rocca Julia Zanetti , Pinheiro Henrique Gabriel Alves Vieira Anacleto , Osowski Vinicios Santos , Campos Junior Ricardo Fernandes
Published: April 2022

O ensino em tentativas discretas (DTT) é um procedimento utilizado amplamente no tratamento de indivíduos com necessidades especiais. Pela sua complexidade, estratégias para treinar pessoas para implementá-lo têm sido investigadas. Uma forma eficaz e econômica tem sido usar manuais autoinstrucionais. O presente estudo teve como objetivo avaliar os efeitos de usar um manual autoinstrucional (traduzido e adaptado para o português brasileiro) como método de treinamento para implementação do DTT. Foram analisados os desempenhos de quatro estudantes universitários na condução do DTT, com pesquisadores representando crianças, em três tarefas (combinar figuras idênticas, imitação motora e apontar figuras nomeadas) antes e após estudar o material. O manual produziu aumento estatisticamente significativo no desempenho dos participantes, mas o efeito foi heterogêneo entre as tarefas. A análise dos resultados por componentes comportamentais revelou efeitos variáveis sobre habilidades específicas. Os resultados corroboram estudos anteriores e indicam a viabilidade do uso da versão brasileira do manual.
Capacitação de profissionais de saúde no manejo de comportamentos problemas em idosos com Transtono Neurocognitivo Maior
Authors: Aggio Natalia M , Parejo Valéria
Published: April 2022

O conhecimento de conceitos básicos em análise do comportamento aplicada é considerado um elemento crítico para a qualidade da prestação de serviço do analista do comportamento. Porém, há escassez na literatura brasileira de cursos que ensinam esse conceitos para profissionais que trabalham com a população idosa. Levando em consideração o aumento de pessoas com transtorno neurocognitivo maior (TNM) e o fato de que problemas de comportamento são mais comuns nessa população, o presente trabalho descreve um curso que teve como objetivo capacitar profissionais a identificar e descrever conceitos básicos relevantes para a atuação no manejo de comportamentos problemas em idosos com TNM. A performance foi aferida por meio de pré e pós testes em um delineamento de sondas múltiplas. Os resultados mostraram melhora no desempenho dos participantes após os curso e manutenção desse bom desempenho. Entende-se que o curso foi efetivo em cumprir seu objetivo.
Genetic Diversity and Distribution of Vitamin D Receptor (VDR) Genotypes in Breast Cancer Cases from Pakistan
Authors: Faiz Mariam , Younus Amna , Yasmeen Abida
Published: April 2022

Background: Breast carcinoma is one of the most commonly diagnosed invasive malignancies in females. In Pakistan, it is more commonly detected in women at a young age as compared to the West. Among all women, the risk of developing breast cancer is equal irrespective of their ethnic or racial basis. The aim of the study was to determine vitamin D receptor gene polymorphisms (FokI and TaqI) and allele frequency distribution in Pakistani women with newly diagnosed breast cancer. This study also aimed to find and compare genetic diversity of VDR polymorphisms among breast cancer cases in different population groups. Methods: Newly diagnosed women having breast cancer (n=300) were selected for the study. Blood samples of all the participants were analyzed for vitamin D levels and isolated DNA was subjected to PCR-RFLP analysis. Results: Results revealed that allelic frequency of FokI and TaqI was ‘F’; ‘f’ 50.67 and 49.33% and ‘T’ and ‘t’ was 46.67 and 53.33 respectively in Pakistani women with breast cancer. The genotypic frequency is significantly (P<0.05) distributed.Conclusion: The current study concluded significant difference in genotypes and allele frequency of VDR gene polymorphism in Pakistani population suffering from breast cancer when compared with other population.
The Role of Autophagy-related Proteins of Beclin-1/BECN1, LC3II, and p62/SQSTM1 in Melanoma Tumors
Authors: Hizomi Arani Reyhaneh , Mohammadpour Hadiseh , Moosavi Mohammad Amin , Muhammadnejad Ahad , Abdollahi Alireza , Rahmati Marveh
Published: April 2022

Purpose: The prognosis of melanoma depends on early diagnosis and timely treatment. Autophagy plays a dual role in tumor progression. In the early stages, it prevents tumor formation, while in the advanced stages it promotes tumorigenicity. This study aimed at investigating the role of autophagy in different stages of melanoma and evaluating the relationship between autophagy and clinicopathological factors. Methods: ATG5 and BECN1 genes expression in melanoma tumors were evaluated in a retrospective study of 5 years in the cancer institute of Tehran, Iran. The autophagy-related proteins and the correlation with clinicopathological data were also investigated in a tissue microarray series of 52 melanoma tumors following by immunohistochemical staining for the autophagy-associated proteins p62/SQSTM1 (p62), LC3II and Beclin-1/BECN1. The possibility of autophagy biomarkers was also predicted by ROC curve analysis. Results: ATG5 and BECN1 gene expression decreased in melanoma tumors in comparison with tumor margins. However, BECN1 expression at the protein level increased with tumor progression. The expression of LC3II also raised while the p62 level declined as the tumor progressed, suggesting an increased autophagy activity during tumor development. Furthermore, melanoma ulceration was positively correlated with BECN1, LC3II and p62 expression with p<0.05, though the melanoma mitotic rate and thickness did not significantly correlate with autophagy–related proteins expression. Conclusions: Autophagy-related proteins are suggested as potential prognostic factors in melanoma and could be considered as a therapeutic target.
A Case of Nodular Fasciitis of the Breast Previously Misdiagnosed as Breast Carcinoma; A Case Report
Authors: Nazar Elham , Hashemi Esmat Alsadat , Ahmadi Seyed Ali , Baloochi Keyvan
Published: April 2022

Introduction: Nodular fasciitis is an exceptional benign soft tissue tumor of the breast that clinically and radiologically can simulate invasive duct carcinoma. Case presentation: We report a case of 67-year-old woman who had a palpable right breast mass of 2 months duration. Sonography showed a hypoechoic heterogeneous round nodule with irregular and speculated borders in right breast. Right breast mass core needle biopsy was inconclusive. Right mastectomy was done due to highly suspicious for malignancy on imaging. Pathological and immunohistochemical examination revealed that the tumor composed of a stellate spindle cell tumor with red blood cells extravasation, compatible with nodular fasciitis. Therefore, pathological evaluation of the lesion is crucial in the assembly of the diagnosis. Conclusion: Nodular fasciitis should be considered in the differential diagnosis of any suspicious breast mass.
Prognostic Impact on Survival of Early Relapse after Autologous Stem Cell Transplantation with Non-cryopreserved Stem Cells for Multiple Myeloma in Real Life: A Single-center Cohort Study from Oran (Algeria)
Authors: Bekadja Mohamed Amine , Mansour Belkacem , Ouldjeriouat Hafida , Garderet Laurent , Benzineb Brahim , Bouchama Samira , Charef Leila , Entasoltan Badra , Yafour Nabil , Belaidi Sofiane
Published: April 2022

Background: The aim of this retrospective study was to analyze early relapse in multiple myeloma (MM) in real life and to evaluate its impact on overall survival (OS) and progression-free survival (PFS). Methods: Two groups of patients were identified according to the date of occurrence of relapse after autologous transplantation, within less than 24 months, defining early relapse (G1), or after more than 24 months, defining late relapse (G2). Results: A total of 307 patients with MM were enrolled, including 93 patients (30%) who had experienced relapse. There were 56 early relapses (18%) and 37 late relapses (12%). In G1 the median follow-up was 19.5 months (3-93), as compared to59 months (24-117) in G2. The median of PFS was 18 months (14.8-21.14) in G1 and was not attained in G2 (p=0.0001). The median of OS was 29 months (18.2-39.7) in G1 and was not attained in G2 (p=0.0001). In a univariate analysis, age>60 years (p=0.003), performance status>1 (p=0.036), LDH>normal (p=0.002), ISS III (p=0.0002) and an absence of maintenance therapy (p=0.002) were found to be predictive factors for early relapse. In a multivariate analysis, only a delay from the initiation of treatment to ASCT of>12 months (p=0.02) and an absence of maintenance therapy (p=0.002) were predictive of early relapse. Conclusion: The predictive factors identified here should allow us to adapt the therapeutic strategy.
Fallacy of Considering Low dose Lung Radiotherapy in Treating Covid Lung
Authors: Durga Tarun
Published: April 2022

There is a raging argument amongst Oncologist regarding offering low dose lung radiotherapy in patients with covid infection with lung symptoms. There is huge enthusiasm amongst medical fraternity and appetite to offer experimental therapies so as to contribute in managing this pandemic associated morbidity and mortality.Although the intentions are noble, offering experimental therapies like Low dose lung radiotherapy without adequate scientific scrutiny risk causing more harm than good for patients. The main argument against Low dose Lung radiotherapy is risk of long term side effects of lung radiation. Simpler alternatives like steroids which are evidence backed are available for managing immunological effects of Covid infection .The epidemiological data strongly suggests that immunolocal lung damage is not the predominant cause of lung toxicity in this infection so targeting this pathway alone is unlikely yield beneficial clinical results. Recent data on lasting lung damage including pulmonary fibrosis in patients who have recovered from covid lung also increase the concerns around Lung Radiotherapy.
Nutrition Impact Symptoms in Relation to Head and Neck Cancer Survivor’s Vegetable Intake and Use of Seasoning
Authors: Goon Shatabdi , Pepino M. Yanina , Arthur Anna , Chapman-Novakofski Karen
Published: April 2022

Background: Most head and neck cancer (HNC) patients undergoing aggressive treatments with chemoradiotherapy and surgical resection of tumors suffer from symptoms long after treatment is completed that hinder adequate oral food intake, collectively known as Nutrition Impact Symptoms (NIS). Our aim was to examine the correlations between NIS and HNC survivors’ vegetable intake and use of seasoning. Methods: We conducted a 29-item telephone administrated survey to collect vegetable intake and seasoning habits among HNC survivors (n=22, age 61.4 ± 9.8 years, mean ± standard deviation) who received radiation therapy between 6 months and 10 years before recruitment identified through the cancer registry at Carle Foundation Hospital. Treatment-related side-effects (11 items) including difficulty swallowing, dry mouth, and mouth sores reflected NIS. A mean composite score was created for all the symptoms where higher scores indicated greater NIS. Spearman correlations examined the relationships between NIS, vegetable intake, and seasoning. Results: Half (50%) of the participants reported no change in their vegetable intake since diagnosis of cancer, and on average, ate 1 cup/day of total vegetables. Higher NIS scores associated with higher pumpkin and sweet potatoes intake (r (20) = .43, p<0.05), and there was a trend for higher scores of difficulties swallowing to be associated with lower corn and peas intake (r (20) =-.37, p=0.08). Participants with higher scores of problems with teeth and gums were less likely to use seasoning (r (20) = -.42, p<0.05). Conclusion: The findings support that HNC treatment can affect vegetable intake long after completion of radiotherapy. However, it would be premature for any recommendations to be derived from the present study for health professionals. A larger, observational study with a longer follow-up is therefore needed to examine these correlations.
Reliability of Oncoplastic Breast Conserving Surgery for Management of Early Breast Cancer in Yemeni Patients
Authors: Alsanabani Jamila Ali , Al-sharafi Butheinah Ali , Al-Nabhi Afif Ahmed
Published: April 2022

Background: Oncoplastic breast conserving surgery is limited in treatment of Yemeni breast cancer. The aim of this study is to evaluate the reliability and safety of oncoplastic breast surgery in Yemeni patients with early breast cancer. Material & Methods: Patients with early breast cancer who underwent oncoplastic breast conserving surgery from July 2014 to July 2020 were included in this retrospective study. Data on the patient’s demographic, tumor characteristics, the type of oncoplastic technique performed, surgical margin involved, re-excision rate, complications, satisfaction, follow up and local recurrence rate were included to evaluate the results. Results: A total of 50 breast cancer patients underwent oncoplastic surgery by using different techniques. Volume displacement technique was the commonest technique used in 92% of the patients (local glandular flap in 64%, reduction mammoplasty in 22%, Grissoti flap in 4% and bat-wing in 2%) While the volume replacement (Latissmus dorsi flap) technique was used in 8 % of the patients with small breasts. 70% of the patients were less than 40 years old. The mean tumor size was 3.4cm. Most of the tumors (84%) was invasive ductal carcinoma. The overall postoperative complication was 14% [wound infection (4%), wound dehiscence (8%) and fat necrosis (2%)]. Re excision rate was 12% and complete mastectomy was performed for 2 patients. Patient satisfaction was 96%. Local recurrence rate was 4% with mean follow up of 23.1 (SD:16) months.Conclusion: The oncoplastic breast conserving surgery is reliable and safe with good oncological and aesthetic outcomes for treatment of early breast cancer in Yemeni patients.
Supportive Care in Cancer Cachexia: Meeting the Unmet Need
Authors: Shankar Abhishek , Singh Pritanjali , Mishra Seema , Gupta Shipra , Roy Shubham , Saini Deepak , Bharati Sachidanand Jee , Seth Tulika , Maheshwari Apoorva , Kumar Ajeet
Published: April 2022

Cachexia is characterized by loss of appetite, weight loss and tissue wasting, accompanied by a decrease in muscle mass and adipose tissue, affecting approximately 50% of cancer patients and contributes to decreased quality of life of patients, reduced tolerance to chemotherapy, and decreased survival. Current therapies focus on maintenance of physical function, quality of life, and reduction of distress in patients and their families rather than definitive treatment for the underlying pathophysiology. Consistent with evolving guidelines for the treatment of cachexia, current models take a multidisciplinary approach, with patients generally seeing a physician, nutritionist or dietician, and physiotherapist sequentially. This is routinely supplemented by psychosocial support, whether within the program or via referral. Early intervention and attention to nutritional status are essential in patients with anorexia-cachexia syndrome. Pharmacological interventions for neoplastic cachexia include drugs that stimulate the appetite: megestrol acetate (MA) and dronabinol; cytokine inhibitors (such as cyproheptadine, thalidomide, pentoxifylline and an eicosapentaenoic acid (EPA)); and anabolic agents such as nandrolone decanoate, oxandrolone and corticosteroids. This review will discuss about the role of supportive care in cancer cachexia with a special emphasis on nursing oncology perspective.
Disease Free Survival in Locally Advanced Breast Cancer: An Analysis of Clinical and Pathological Factors
Authors: Singh Anuj Sharma , Bhardwaj Barasha Sarma , Goswami B.C
Published: April 2022

Background: The TNM stage is the widely accepted tool to predict prognosis in breast cancer cases, but it deals with a limited range of factors and ignores patient-specific conditions, pathological or genotype characteristics and treatments. The purpose of this study was to evaluate if and how different clinical (tobacco chewing, age etc) and pathological (lymphovascular and perineural invasion etc) variables influence the disease free survival. Material and Methods: This study involves North Eastern Indian population. Data of 101 patients with locally advanced breast cancer diagnosed in the time period of January to December 2018 was probed and they were followed up till March 2020. Association between various clinicopathological risk factors and disease free survival was assessed using univariate and multivariate models. Survival estimates were computed using the Kaplan-Meier method and differences between survival times were assessed by means of the Log rank test. Multivariate analyses were carried out using Cox’s proportional hazards model. Results: During follow up period 14 patients developed metastasis. There was significantly reduced disease free survival seen trough Kaplan Meier plots in patients having tumor size >6 cm, N2/ N3 stage, triple negative receptor status, tobacco chewing and positive perineural invasion. Multivariate analysis revealed that stage (N2, N3) and positive perineural invasion are two independent variables which adversely affect the survival. Conclusion: Bottom line of the study is that, disease free survival in LABC patients is significantly reduced with higher stage (N2, N3) and positive perineural invasion as revealed by multivariate analysis. Three other factors which adversely affect DFS are tobacco chewing, tumor size > 6cm and triple negative hormone receptor status according to univariate analysis.
Correlating Fine Needle Aspiration Cytology Results of Mammary Malignancy with Corresponding Ultrasound BIRADS Score
Authors: Khaleel Mohson
Published: April 2022

Objective: Breast mass is a major complaint making women attending any breast clinic. About 10% of the lumps are usually malignant. Triple assessment techniques using clinical examination, ultrasound, and cytology are usually sufficient in reaching the final diagnosis, especially in specialized breast centers. The aim of this study was to assess how accurate ultrasound was in the diagnosis of definite breast cancer according to BIRADS (Breast Imaging Reporting and Data System), and correlate these radiological findings with the results of fineneedle aspiration cytology (FNAC). Methods: A retrospective study included 42 patients who presented with a self-detected breast lump and attending the Early Detection of Breast Tumors clinic in the Oncology Teaching Hospital, Medical City Complex, Baghdad during the period from May 2019 to August 2020. Their age ranged from 29 to 92 years. Patients underwent ultrasound examination after clinical examination and the reported BIRADS score was correlated with the corresponding cytology data. Results: the main ultrasound findings are masses that are either irregular in the majority of cases and this represents 55%, poorly demarcated lesions seen in (26%) while 14% of them were well defined. axillary lymphadenopathy with typical malignant features was noted in (50%). FNAC revealed mammary carcinoma in (93%); while severe atypia was seen in 7%, BIRADS V score was assigned in 76%, of breast exam BIRADS IV in 21% while the remaining 3% were in BIRADS III category. By correlating these ultrasound findings of BIRADS with FNAC results, the ultrasound accuracy in the diagnosis of breast cancer was reaching to 90%. Conclusion: Ultrasonography represents an accurate diagnostic radiological modality for any breast lesion and is thus considered a recommended method for assessment of underlying cause responsible for palpable breast mass or any presenting symptoms related to the breasts. Its value was demonstrated in characterizing the mass lesion, assessing its location, its echo texture, margin, and size, it has a major role in analyzing the axilla for normal or pathological lymph nodes.
Outcome of Primary CNS Lymphoma; A Retrospective Analysis
Authors: Shahzadi Mehwish , Ahmed Daniyaal , Sawani Sobia , Moosajee Munira
Published: April 2022

Background: Rituximab along with high dose Methotrexate is nowadays the standard of care in treatment of PCNSL. We report the retrospective analysis of PCNSL patients who were treated with and without Rituximab at Aga Khan University Hospital, Karachi. Patients and Methods: While analyzing seven years’ data of PCNSL patients at Aga Khan University hospital, 52 patients encounter this rare disease. Patients diagnosed were around 54 years of age and with male predominance. HIV status though checked in 50% of patient was found to be negative in all. 36 patients completed treatment and among them 60% patients could not receive Rituximab during the course of treatment with high cost being the only reason of not receiving anti-CD 20 monoclonal antibody. Radiation as a part of consolidation therapy was received by 20 patients who achieved CR followed by two cycles of Cytarabine. Results: Out of 36 treated patients, 17% patients (6 out of 36) had disease progression. The median progression free survival was 51 months (Hazard Ratio of 0.594, 95% Confidence Interval CI, 0.182, 1.934; p < 0.388). The addition of Rituximab monoclonal antibody to the chemotherapy regimen improved the PFS. However, 41% patients (9 out of 22) who did not receive Rituximab had no response after induction as compared to 29% patients (4 out of 14) who received Rituximab. The mean overall survival of treated PCNSL patients was 67 months (Hazard Ratio of 8.52, 95% CI 0.974, 74.51, p< 0.053). Within the cohort of 36 patients, 61% patients (22 out of 36) were still alive at the time of analysis. Among 39% who were dead, the most common causes were sepsis and progression of disease. Conclusion: Primary CNS lymphoma though an aggressive entity can be cured with the combination of chemo-immunotherapy with a progression free survival and overall survival of about four to five years.
Knowledge and Practice of Breast Self-examination among Women in Yavataml, India, A Cross- Sectional Study
Authors: Gore Sushma , Yelake Vishal , Dudhe Mayur
Published: April 2022

Objectives: Worldwide breast cancer is the most common cancer among women. By 2030 the global burden of breast cancer is expected to exceed 2 million, with increasing proportions from developing countries. The aim of this study was to assess awareness about breast cancer among women attending in a gynecological clinic in rural area India. Materials & Methods: It was a cross sectional study done for period of 3months among women attending & Gynae OPD of rural medical college. A total of 460 study participants were enrolled during the study period. Results: About 85% were aware about the disease. Among participants who were aware 41% said its due to obesity, 24.74% said because of genetic,16.32% said due to advancing age and 17.60% said due to inadequate breast feeding. It was observed that 52.80% were aware that biopsy is the first modality of diagnosing breast cancer. And 59.43% were aware about Breast Self-Examination. Conclusion: Awareness about breast cancer among the study participants was good in the present study. Intense health education campaign should be conducted at regular intervals regarding BSE importance. Women should be taught how to do BSE as BSE is the main screening modality which will detect early stage of cancer.
Cell of Origin Based on Hans’ Algorithm as Prognostic Factor in Diffuse Large B-Cell Lymphoma: A Clinicopathologic and Survival Study
Authors: Probowati Wiwiek , Purwanto Ibnu , Anggorowati Nungki , Setiawan Syahru Agung , Bagaskoro Miraz Radhea , Dinantia Nugira , Kurnianda Johan , Taroeno-Hariadi Kartika Widayati , Hutajulu Susanna Hilda , Hardianti Mardiah Suci
Published: April 2022

Background: Diffuse Large B-Cell Lymphoma (DLBCL) has been classified based on Cell of Origin (COO) into Germinal Center B-cell (GCB) and Non-Germinal Center B-cell (Non-GCB). The practical application of this concept by immunohistochemistry (IHC)-based subtyping with Hans’ algorithm and its role as a prognostic factor has been widely investigated with conflicting results. Moreover, the recent deeper molecular characterizations of DLBCL have been another challenges for this approach to remain as a prognostic factor. Objective: To determine the prognostic value of COO by IHC-based subtyping with Hans’ algorithm for DLBCL. Materials and Methods: This was a single-center retrospective analysis including DLBCL cases diagnosed in 2014-2019 from Dr. Sardjito Hospital, Yogyakarta, Indonesia. Hans’ algorithm with CD10, BCL6, and MUM1 were used. The two subtypes were compared in terms of clinicopathological features and 3 years overall survival. Results: Seventy patients were included in this study. Non-GCB was predominant than GCB 74.3% vs 25.7%, with the ratio of 2.8:1. No statistical difference in the clinicopathological features from both subtypes in terms of age, gender, Ann Arbor stadium, ECOG performance status, extra-nodal involvement, and LDH level. Ann Arbor stadium and ECOG showed significant prognostic value for patients outcome with multivariate analysis (OR 3.64; 95%CI 0.18-0.61; p=0.001) and (OR 2.68; 95%CI 0.11-0.77; p=0.009). Survival analysis based on COO did not show significant difference between GCB and non-GCB subtypes (log rank=0.46). Further analysis based on COO and the use of rituximab showed better OS in the two subtypes than without rituximab although not significant (log rank=0.67). Conclusion: The role of COO with Hans’ algorithm as prognostic factor in DLBCL is not confirmed in this study. Some related factors may be the addition of rituximab and the recent molecular characterization of DLBCL which covered a more subtle classification of the disease beyond GCB and non-GCB subtypes.
« Que faire de la gestion de fait ? »
Authors: Quinart Emilien
Published: April 2022

La loi de finances pour 2022 habilite le Gouvernement à « moderniser » le régime spécifique de la gestion de fait. En excluant les ministres et les élus locaux du champ des justiciables de la future juridiction financière et en abandonnant la logique restitutive de la responsabilité des gestionnaires publics au profit d’une pure logique répressive, la réforme se présente – sur ce point – comme un recul du droit. L’instance en gestion de fait apparaît au contraire comme une réponse à ces deux exigences de justice. Elle mériterait donc d’être conservée. À plus forte raison que, loin d’être archaïque, elle s’est profondément modernisée dans la période la plus récente et répond parfaitement aux objectifs recherchés d’une réforme de la responsabilité du gestionnaire public, recentrée sur les situations les plus graves et adaptée à l’exigence de performance.
L’évolution de la structure du financement de la sécurite sociale sur 20 ans (2001-2020)
Authors: Terrasse Yves , Douat Étienne
Published: April 2022

Au cours de la période 2001-2020, en 20 ans, les cotisations sociales effectives sont passées de 59 à 48 % du financement des ROBSS. En sens inverse, les impôts ont grimpé de 20 à 37 %. La place de la CSG, créée en 1991, s’est consolidée en passant de 16 à 19 %. De plus en plus d’impôts et taxes ont été affectés à la sécurité sociale ce qui a quasiment permis de doubler la CSG. En particulier, la part de la TVA est devenue massive depuis 2019 pour financer les exonérations sur les bas salaires.
EXTRAVERTED CHILDREN SWIM FASTER COMPARED TO INTROVERTED COUNTERPARTS REGARDLESS OF LIGHT AND SOUND NOISE LEVELS
Authors: Barroso Flavia F , Gomes Fabio R. F. , Ponciano Katia R. , Massa Marcelo , Meira Jr. Cassio M.
Published: April 2022

Individual differences of personality are thought to influence motor performance. In terms of cortical arousal levels, because extraverts are infra-activated and introverts are hyper-activated, environment stimuli might enhance the impact of the extraversion trait on task performance. This study investigated the effect of light and sound noise on the swimming performance of extraverted and introverted children. 19 extraverts (12 boys, 7 girls) and 22 introverts (12 boys, 10 girls), ages 8.2 ± 0.9 years, adapted to water and swimming at intermediate levels. Participants performed two trials of the task (swimming 15 meters as fast as possible in crawl style) under two environment conditions: bright light/loud noise (A) and dim light/slight noise (B). Movements were filmed to allow calculation of time to complete the task and the stroke cycle. There was a significant effect for the group factor, with extraverts swimming faster than introverts. No effect was detected for the environment factor or the interaction group/environment. Regarding stroke cycle, no differences were found for group, environment or interaction. Although extraversion has not affected mechanical aspects of crawl style, compared to introverts, extraverts swan faster, showing a more effective process of reacting and executing movements in time-constraints tasks.
POTENCIAIS BENEFICIOS E BARREIRAS DA MOBILIDADE MOTORIZADA: UMA REVISÃO DE LITERATURA
Authors: Diogo Leticia Ribeiro , Magalhães Elton Dantas Duarte , Chiari Devika Prem Chandiramani , Silva Denise De Faria , Velasko Stefany Gomes da Silva , Chagas Paula Silva de Carvalho
Published: April 2022

INTRODUÇÃO: No Brasil, 23,9% da população total possui algum tipo de deficiência visual, auditiva, motora ou intelectual, desses, 7,53% são crianças de 0 a 14 anos que sofrem com algum tipo de deficiência. Várias condições como síndrome de down, paralisia cerebral e espinha bífida podem acometer as crianças e sua capacidade de se movimentar e se envolver em mobilidade autodirigida. OBJETIVO: Identificar os potenciais benefícios e as barreiras da implementação da mobilidade motorizada. MÉTODOS: Foi realizada uma revisão narrativa e compreensiva dos artigos científicos sobre o tema proposto. A busca foi conduzida nas bases virtuais (PubMED, MEDLINE e Physiotherapy Evidence Database (PEDro), no período compreendido de junho a agosto de 2021.  Os descritores utilizados na busca literária foram: children, mobility, early motorization, motorized mobility. RESULTADOS: Foram identificados 25 artigos utilizando a estratégia de busca nas bases de dados. Após a leitura dos resumos foram excluídos 13 artigos, após a leitura crítica e análise dos materiais foram selecionados 12 artigos, dos 12 avaliados foram excluídos 4 pois não abordavam o tema, restando 8 artigos para a revisão. CONCLUSÃO: Os carrinhos motorizados e adaptados para crianças com algum distúrbio de marcha são viáveis e divertidos, apresentam potenciais benefícios para ganho de mobilidade e socialização. As principais limitações estão relacionadas ao desenvolvimento de estudos com uma metodologia e protocolos específicos. Estudos envolvendo mobilidade motorizada são viáveis e bem aceitos pela comunidade. O uso de mobilidade motorizada possui potenciais benefícios para mobilidade e socialização. As principais barreiras encontradas foram barreiras do ambiente.
OSTEONECROSE INDUZIDA POR GLICOCORTICOIDES EM PACIENTES COM LÚPUS ERITEMATOSO SISTÊMICO: UMA REVISÃO SISTEMÁTICA
Authors: Pinheiro Lauanne Beatriz , Lima Andressa Torres , Silva Nilzo Antonio da
Published: April 2022

Objetivo: esclarecer a relação da osteonecrose (ON) induzida por glicocorticoides em pacientes com lúpus eritematoso sistêmico (LES) e verificar se há uma relação dose x duração, a partir do método de revisão sistemática. Métodos: Uma busca sistemática na literatura foi realizada nos portais PubMed, LILACS, SciELO e Cochrane Library. Essa busca priorizou estudos publicados entre os anos 2009-2019, que envolvessem o uso de glicocorticoides como forma de tratamento do LES e que tinham como desdobramento, a presença de ON. Resultados: De 1.051 artigos previamente identificados nas bases de dados, foram selecionados 6 estudos que se adequaram aos critérios estabelecidos para esta revisão sistemática. Os artigos indicaram grande tendência da presença de ON nos pacientes em uso de corticosteroides, demonstrando que doses maiores, tendem a aumentar a chance desta manifestação. A idade de diagnóstico mais precoce do LES, mostrou maior relação com o aparecimento da ON, manifestando-se principalmente na articulação do quadril. Conclusão: Embora a maioria dos estudos aponte para a relação da corticoterapia no que diz respeito à dose e tempo com o surgimento da ON, um número maior de estudos precisa ser avaliado, visto que alguns dos nossos achados demonstram esta manifestação com doses equivalentes a 7,5mg/dia, enquanto outro encontrou a possibilidade deste desdobramento ser próprio do curso da doença. PALAVRAS-CHAVE: lúpus eritematoso sistêmico; osteonecrose; glicocorticoides
OS DESAFIOS DA APLICAÇÃO DO MODELO BIOPSICOSSOCIAL NOS CENTROS DE REABILITAÇÃO
Authors: Fernandes Denise Vasconcelos , Cavalcante Neto Jorge Lopes , Souza Márcio Costa de , Mercês Magno Conceição das
Published: April 2022

A Funcionalidade é o termo descrito para caracterizar os aspectos positivos das experiências humanas sobre a ótica individual, biológica e social, que condensa a materialização da saúde biológica com a saúde vivida e abrange as funções e estruturas do corpo, atividades e participação1–3. Reconhecida pela Organização Mundial da Saúde (OMS) como terceiro indicador mundial de saúde, junto à morbidade e mortalidade, ela é resultante da interação ou relação complexa entre fatores do contexto e o estado ou condição de saúde de cada indivíduo1. Para definir a Funcionalidade e a Incapacidade (que representa o conjunto de experiências negativas vivenciadas - deficiências, limitações de atividades ou restrições na participação), a OMS elaborou em 2001 a Classificação Internacional de Funcionalidade, Incapacidade e Saúde, a CIF, com o objetivo de instituir uma linguagem padronizada e unificada, na perspectiva do modelo biopsicossocial, sobre os aspectos de saúde e relacionados à saúde, de forma a permitir um melhor delineamento das atribuições de uma equipe de saúde sob o prisma da colaboração interprofissional, a operacionalização da oferta do cuidado integral e o planejamento estratégico de ações centradas no usuário e suas demandas1,2
Collaboration In Implementing Problem Based Learning For Nursing Education
Authors: Rakhudu Mahlasela Annah , Maselesele Mashudu Davhana , Useh Ushonatefe
Published: April 2022

Background:  Problem based learning is advocate as teaching strategy for development of the 21st century health care practitioners. Collaborative partnerships are much-touted values in organizational life today

Purpose: To explore and describe the perceptions of nurse educators and manager on collaboration in implementing PBL in nursing education in South African context

Methodology: An exploratory sequential mixed method was used to collect data from purposively recruited participants from three of the five South African universities implementing PBL in nursing education and three North-West Provincial hospitals where PBL students are place for clinical learning. Ethical clearance certificate is NWU-00033-11-A9

Results: Both qualitative and quantitative data indicated the need for various types of collaboration; benefits of collaboration to staff, students, organizations and health care users; factors to successful collaboration in implementing PBL

Conclusions: Successful implementation of PBL can be achieved through collaboration of clinical spaces. The strategic management and leadership should be committed to the collaboration by offering support and commitment of time, energy and resources.  

Recommendations For practice, the strategic management and leadership should be committed to the collaboration by offering support, commitment of time, energy and resources. Effective communication should be to promote participation in the collaboration. Further research on collaboration in implementing PBL at different levels of operations; cultural influences on collaboration; criteria to assess effectiveness of collaboration is necessary.
Simulation of aircraft navigation L410 UVP - E20
Authors: Volner Rudolf
Published: April 2022

The article describes the basics of navigation procedures for air transport. The specialization is characterized for defining the application for L 410 aircraft. The modeling is based on the classical algorithm design of the given problem.
Становлення ґендерної ідентичності хлопців у неповній сім’ї
Authors:   , Боровцова Мар’яна Сергіївна
Published: April 2022

Дисертація на здобуття наукового ступеня кандидата психологічних наук за спеціальністю 19.00.01 – загальна психологія, історія психології. – Дніпропетровський національний університет імені Олеся Гончара МОНмолодьспорту України, Дніпропетровськ, 2013. У дисертації здійснено теоретичне обґрунтування та емпіричне вивчення особливостей становлення ґендерної ідентичності хлопців у неповній сім’ї. Визначено теоретико-методологічні підходи до вивчення ґендерної ідентичності, уточнено її зміст та зв’язок із ґендером особистості, здійснено аналіз типологій ґендерної ідентичності, з’ясовано основні детермінанти, хід та новоутворення становлення ґендерної ідентичності особистості в онтогенезі, розкрито особливості становлення ґендерної ідентичності чоловіка, визначено можливості та обмеження неповної сім’ї як агента становлення ґендерної ідентичності хлопця. Розроблено діагностичний комплекс, що уможливив дослідження особливостей ґендерної ідентичності хлопців та її становлення на трьох рівнях функціонування: глибинному, когнітивному та поведінковому. Зокрема, запропоновано бланк для вивчення глибинного компонента ґендерної ідентичності особистості методом аналізу серії психомалюнків: «Я», «Чоловік» та «Жінка». Внаслідок проведеного емпіричного дослідження встановлено особливості ґендерної ідентичності хлопців молодшого шкільного, підліткового та юнацького віку, що зростають у неповній сім’ї, а також особливості становлення когнітивного, поведінкового та глибинного компонента ґендерної ідентичності хлопців з неповних сімей і її структури.
Ортобіотика як засіб збереження здоров’я майбутнього вчителя
Authors: Дороніна Т. О.
Published: April 2022

У статті актуалізовано проблему навчання майбутнього вчителя технікам ортобіотики задля збереження його особистого здоров’я у подальшій практичній діяльності. Уведення до навчальних планів із підготовки вчителя дисципліни «Педагогічна ортобіотика» дозволить сформувати у випускників педагогічних навчальних закладів стійки навички збереження власного здоров’я, що неминуче позначиться і на якості життя самого вчителя, і на якості його професійної діяльності.
Рівень адаптаційного потенціалу першокласників в умовах промислового міста
Authors: Марчик Валентина Іванівна , Шутько Віктор Васильович
Published: April 2022

Адаптаційний потенціал серцево-судинної системи першокласників в умовах промислового міста Кривого Рогу, яке очолює рейтинг найбрудніших міст і входить до п’ятірки найбільш радіаційно-небезпечних територій України, визначається за модифікованою формулою Баєвського для учнів початкової школи, незадовільним рівнем. Показники школярів міста-мегаполіса Дніпро наближаються до критичної межі, після якої задовільний рівень адаптаційного потенціалу буде характеризуватися як напружений. У першокласників сільської місцевості зафіксовані кращі показники індексу функціональних змін у порівнянні з аналогічними показниками першокласників, які проживають у промислових містах.
Плавання як важливий фактор розвитку фізичних здібностей студентів
Authors: Письменний Олександр Миколайович
Published: April 2022

Визначені роль та місце занять плаванням в системі фізичного виховання студентської молоді та забезпечення дотримання нею основ здорового способу життя. Розглядаються методичні особливості побудови занять з плавання зі студентами вищих навчальних закладів та їх вплив на розвиток фізичних здібностей і функціональні можливості організму людини. Наведені результати дослідження щодо визначення динаміки розвитку фізичних здібностей та фізичної підготовленості студентів віком 18 та 19 років, необхідних для виконання ефективних дій в умовах середньостатистичного ВНЗ, з урахуванням застосування засобів фізичної підготовки в процесі занять плаванням.
Здоров’язберігаючі аспекти самореалізації особистості в різних умовах
Authors: Марчик Валентина Іванівна , Бороденко Вікторія Іванівна , Шабля Валентина Миколаївна
Published: April 2022

У використанні здоров’язбережувальних технологій виявлена ефективність державної системи освіти. Школярі старших класів і студенти активно користуються фізкультурно-оздоровчими засобами різних форм. В період зрілого віку в людини різко знижується активність в руховій діяльності. В найманій праці нормований робочий день не є перепоною для занять фізичними вправами, якщо сформовані звички здорового способу життя. Велика роль надається педагогу у формуванні в учнів і молоді ціннісного ставлення до себе та власного здоров’я у всіх проявах.