bluuebunny/crossref_metadata_2025 huggingface dataset:
Qualität der dermatologischen Versorgung von Neurodermitis in Deutschland – keine Verbesserung der Indikatoren nach 10 Jahren
Authors: Langenbruch A. , Mohr N. , Abeck F. , Schmitt J. , Ständer S. , Werfel T. , Thaçi D. , Weidinger S. , Augustin M.
Published: September 2021

Hintergrund

Mit AtopicHealth1 wurde 2010 die erste nationale Versorgungsstudie zur AD durchgeführt. Damals zeigte etwa ein Drittel der Patienten, die sich in einer Behandlung bei Dermatologen befanden, starke Einschränkungen der Lebensqualität, was auf eine unzureichende Versorgungsqualität hindeutete. Ziel der vorliegenden Studie war die Charakterisierung der aktuellen Versorgung von Patienten mit Neurodermitis in dermatologischer Behandlung im Schweregradvergleich sowie im Vergleich zu 2010 und zu Psoriasis.

Methode

Die deutschlandweite multizentrische Querschnittstudie „AtopicHealth2“ erfasste klinische Daten, Lebensqualität (DLQI), Therapien, präventives Verhalten und patientendefinierten Behandlungsnutzen (PBI). Patienten mit einer Indikation für Systemtherapie wurden für Subgruppenanalysen als mittelschwer bis schwer, die anderen als leicht betroffen angesehen.

Ergebnisse

Zwischen 2017 und 2019 wurden 1291 Patienten durch 111 Zentren eingeschlossen, mittleres Alter 41 Jahre, 56,5 % weiblich. Im Vergleich zu 2010 fanden sich keine Verbesserungen hinsichtlich Lebensqualität (jeweils DLQI 8,5), Schweregrad (SCORAD 45,4 vs. 42,3 in 2010) und Therapienutzen (PBI 2,2 vs. 2,4 in 2010). Mittelschwer bis schwer betroffene Patienten zeigten häufiger Lebensqualitätseinbuße (45,4 % vs. 23,6 %) und seltener relevante Therapienutzen (PBI < 1: 21,3 % vs. 13,2 %) als leichter betroffene. Verglichen mit Psoriasis offenbarten die Patienten mit Neurodermitis höhere Lebensqualitätseinschränkungen (DLQI 8,5 vs. 6,1) und einen geringeren Behandlungsnutzen (PBI 2,2 vs. 2,8).

Diskussion

Im Vergleich zu 2010 zeigt sich keine verbesserte Versorgungsqualität von Neurodermitis in Deutschland. Im Vergleich zur Psoriasis weisen Patienten mit Neurodermitis höhere Belastungen und geringere therapeutische Nutzen auf, was den Bedarf an therapeutischen Innovationen unterstreicht.
Aggregation, asymmetry, and common factors for Bangladesh’s exchange rate–trade balance relation
Authors: Khatoon Rabeya , Hasan Md Emran , Ibon Md Wahid Ferdous , Islam Shahidul , Mehareen Jeenat , Murshed Rubaiya , Pabon Md Nahid Ferdous , Rahman Md. Jillur , Shuchi Musharrat Shabnam
Published: September 2021

We present an application of the recent CS-ARDL methodology in the context of a country’s trade balance–exchange rate relationship. The trade balance is expected to deteriorate first before improving in response to currency depreciation and vice versa, widely known as the J-curve effect satisfying the Marshall–Lerner condition in the long run. Combining bilateral and aggregate analysis in one setting by constructing specific panel data with one reference country, we find that aggregate analysis is sensitive to our allowance for heterogeneity. Estimates using the aggregate time series data show evidence favoring the J-curve relation, whereas the aggregate analysis resulting from the panel time series data shows that currency appreciation improves trade balance in Bangladesh in the long run, which goes against the Marshall–Lerner condition. With the reference of the existing commodity-level literature, we argue that this atypical scenario lines with the realities of a ‘small’ economy like Bangladesh, where her exporters attempt to maintain their market share with some government support. The study provides essential policy suggestions by identifying the significant contributors to Bangladesh’s trade balance–exchange rate relationship: China, Japan, and Singapore.
The Milnor-Moore theorem for $$L_\infty $$ algebras in rational homotopy theory
Authors: Moreno Fernández José Manuel
Published: September 2021

We give a construction of the universal enveloping $$A_\infty $$

A
∞

algebra of a given $$L_\infty $$

L
∞

algebra, alternative to the already existing versions. As applications, we derive a higher homotopy algebras version of the classical Milnor-Moore theorem. This proposes a new $$A_\infty $$

A
∞

model for simply connected rational homotopy types, and uncovers a relationship between the higher order rational Whitehead products in homotopy groups and the Pontryagin-Massey products in the rational loop space homology algebra.
Development of thermostable sucrose phosphorylase by semi-rational design for efficient biosynthesis of alpha-D-glucosylglycerol
Authors: Xia Yuanyuan , Li Xiaoyu , Yang Linli , Luo Xiaozhou , Shen Wei , Cao Yu , Peplowski Lukasz , Chen Xianzhong
Published: September 2021

Sucrose phosphorylase (SPase) can specifically catalyze transglycosylation reactions and can be used to enzymatically synthesize α-D-glycosides. However, the low thermostability of SPase has been a bottleneck for its industrial application. In this study, a SPase gene from Leuconostoc mesenteroides ATCC 12,291 (LmSPase) was synthesized with optimized codons and overexpressed successfully in Escherichia coli. A semi-rational design strategy that combined the FireProt (a web server designing thermostable proteins), structure–function analysis, and molecular dynamic simulations was used to improve the thermostability of LmSPase. Finally, one single-point mutation T219L and a combination mutation I31F/T219L/T263L/S360A (Mut4) with improved thermostability were obtained. The half-lives at 50 °C of T219L and Mut4 both increased approximately two-fold compared to that of wild-type LmSPase (WT). Furthermore, the two variants T219L and Mut4 were used to produce α-D-glucosylglycerol (αGG) from sucrose and glycerol by incubating with 40 U/mL crude extracts at 37 °C for 60 h and achieved the product concentration of 193.2 ± 12.9 g/L and 195.8 ± 13.1 g/L, respectively, which were approximately 1.3-fold higher than that of WT (150.4 ± 10.0 g/L). This study provides an effective strategy for improving the thermostability of an industrial enzyme.

Key points

• Predicted potential hotspot residues directing the thermostability of LmSPase by semi-rational design

• Screened two positive variants with higher thermostability and higher activity

• Synthesized α-D-glucosylglycerol to a high level by two screened positive variants
Fine-scale morphological, genomic, reproductive, and symbiont differences delimit the Caribbean octocorals Plexaura homomalla and P. kükenthali
Authors: Pelosi Jessie A. , Bernal Moisés A. , Krabbenhoft Trevor J. , Galbo Samantha , Prada Carlos , Coffroth Mary Alice , Lasker Howard
Published: September 2021

Octocorals are conspicuous members of coral reefs and deep-sea ecosystems. Yet, species boundaries and taxonomic relationships within this group remain poorly understood, hindering our understanding of this essential component of the marine fauna. We used a multifaceted approach to revisit the systematics of the Caribbean octocorals Plexaura homomalla and Plexaura kükenthali, two taxa that have a long history of taxonomic revisions. We integrated morphological and reproductive analyses with high-throughput sequencing technology to clarify the relationship between these common gorgonians. Although size and shape of the sclerites are significantly different, there is overlap in the distributions making identification based on sclerites alone difficult. Differences in reproductive timing and mode of larval development were detected, suggesting possible mechanisms of pre-zygotic isolation. Furthermore, there are substantial genetic differences and clear separation of the two species in nuclear introns and single-nucleotide polymorphisms obtained from de novo assembled transcriptomes. Despite these differences, analyses with SNPs suggest that hybridization is still possible between the two groups. The two nascent species also differed in their symbiont communities (genus Breviolum) across multiple sampling sites in the Caribbean. Despite a complicated history of taxonomic revisions, our results support the differentiation of P. homomalla and P. kükenthali, emphasizing that integrative approaches are essential for Anthozoan systematics.
Serum exosomal miRNA from endometriosis patients correlates with disease severity
Authors: Wu Yahong , Yuan Wen , Ding Hui , Wu Xianqing
Published: September 2021

Purpose

Exosomes are vesicles secreted by cells that contain a wide variety of biomolecules, including proteins or nucleic acids. MicroRNAs (miRNAs), which are commonly found in exosomes, are known to play important roles in the pathophysiology of endometriosis.

Methods

This study investigated the miRNA expression profile of serum exosomes from women with endometriosis in comparison with normal controls as well as the possible role of identified miRNAs in the pathogenesis of endometriosis. Exosomes with a diameter between 60 and 100 nm were identified by their expression of exosomal marker proteins CD9 and CD63.

Results

Microarray miRNA expression profiling analysis revealed that 26 genes were significantly up-regulated and 19 genes were significantly down-regulated in serum exosomes from endometriosis patients compared with normal controls. These differentially expressed miRNAs were mainly enriched in the regulation of cellular development, metabolism, and involved in the regulation of the MAPK and PI3k-Akt pathways. qRT-PCR analysis verified the differential expression of three miRNAs, miR-26b-5p, miR-215-5p, and miR-6795-3p.

Conclusion

Further analysis indicated that these differentially expressed miRNAs in serum exosomes may be involved in the pathogenesis of endometriosis and are related to the severity and certain symptoms of endometriosis.
Olfactory receptor Olfr78 (prostate-specific G protein-coupled receptor PSGR) expression in arterioles supplying skeletal and cardiac muscles and in arterioles feeding some murine organs
Authors: Mermer Petra , Strotmann Jörg , Kummer Wolfgang , Paddenberg Renate
Published: September 2021

The olfactory receptor Olfr78 (prostate-specific G protein-coupled receptor PSGR) is a member of the G protein-coupled receptor family mediating olfactory chemosensation, but it is additionally expressed in other tissues. Olfr78 expressed in kidney participates in blood pressure regulation, and in prostate it plays a role in the development of cancer. We here screened many organs/tissues of transgenic mice co-expressing β-galactosidase with Olfr78. X-gal-positive cells were detectable in smooth muscle cells of numerous arterioles of striated muscles (heart ventricles and skeletal muscles of various embryological origin). In addition, in most organs where we found expression of Olfr78 mRNA, X-gal staining was restricted to smooth muscle cells of small blood vessels. The dominant expression of Olfr78 in arteriolar smooth muscle cells supports the concept of an important role in blood pressure regulation and suggests a participation in the fine tuning of blood supply especially of striated muscles. This should be considered when targeting Olfr78 in other contexts such as prostate cancer.
Eine Bedrohung für den Sinn? Human Enhancement und das sinnvolle Leben
Authors: Rüther Markus
Published: September 2021

Das allgemeine Thema des Artikels besteht darin, zwei Diskussionskreise miteinander zu verbinden, die in Isolation betrachtet gut erforscht sind, aber selten zusammengebracht werden: die Diskussion um das sogenannte Human Enhancement und die Debatte um das sinnvolle Leben. Hierbei wird insbesondere die Behauptung ins Blickfeld gerückt, dass Techniken des Human Enhancement einen negativen Einfluss auf den Sinn haben könnten. Ist diese These plausibel? In diesem Artikel wird die These verteidigt, dass diese Frage verneint werden muss. Methodisch werden hierfür drei Varianten untersucht, in denen die Behauptung des negativen Einflusses vorgetragen werden können. Dabei wird aufgezeigt, dass entweder die Annahme eines negativen Einflusses aus empirischen Gründen wenig wahrscheinlich ist oder dass sie durch Modifikationen der Enhancement Techniken abgeschwächt werden können.
Understanding long-term groundwater flow at Pahute Mesa and vicinity, Nevada National Security Site, USA, from naturally occurring geochemical and isotopic tracers
Authors: Kwicklis Edward , Farnham Irene , Hershey Ronald L. , Visser Ate , Hoaglund John
Published: September 2021

Recently collected naturally occurring geochemical and isotopic groundwater tracers were combined with historic data from the Pahute Mesa area of the Nevada National Security Site (NNSS), Nevada, USA, to provide insights into long-term regional groundwater flow patterns, mixing and recharge. Pahute Mesa was the site of 85 nuclear detonations between 1965 and 1992, many of them deeply buried devices that introduced radionuclides directly into groundwater. The dataset examined included major ions and field measurements, stable isotopes of hydrogen (δ2H), oxygen (δ18O), carbon (δ13C) and sulfur (δ34S), and radioisotopes of carbon (14C) and chloride (36Cl). Analysis of the patterns of groundwater 14C data and the δ2H and δ18O signatures indicates that groundwater recharge is predominantly of Pleistocene age, except for a few localized areas near major ephemeral drainages. Steep gradients in sulfate (SO4) and chloride (Cl) define a region near the western edge of the NNSS where high-concentration groundwater flowing south from north of the NNSS merges with dilute groundwater flowing west from eastern Pahute Mesa in a mixing zone that coincides with a groundwater trough associated with major faults. The 36Cl/Cl and δ34S data suggest that the source of the high Cl and SO4 in the groundwater was a now-dry, pluvial-age playa lake north of the NNSS. Patterns of groundwater flow indicated by the combined data sets show that groundwater is flowing around the northwest margin of the now extinct Timber Mountain Caldera Complex toward regional discharge areas in Oasis Valley.
Terrestrial ecosystems buffer inputs through storage and recycling of elements
Authors: Spohn Marie , Aburto Felipe , Ehlers Todd A. , Farwig Nina , Frings Patrick J. , Hartmann Henrik , Hoffmann Thomas , Larsen Annegret , Oelmann Yvonne
Published: September 2021

This study presents a conceptual framework of buffering through storage and recycling of elements in terrestrial ecosystems and reviews the current knowledge about storage and recycling of elements in plants and ecosystems. Terrestrial ecosystems, defined here as plant-soil systems, buffer inputs from the atmosphere and bedrock through storage and recycling of elements, i.e., they dampen and delay their responses to inputs. Our framework challenges conventional paradigms of ecosystem resistance derived from plant community dynamics, and instead shows that element pools and fluxes have an overriding effect on the sensitivity of ecosystems to environmental change. While storage pools allow ecosystems to buffer variability in inputs over short to intermediate periods, recycling of elements enables ecosystems to buffer inputs over longer periods. The conceptual framework presented here improves our ability to predict the responses of ecosystems to environmental change. This is urgently needed to define thresholds which must not be exceeded to guarantee ecosystem functioning. This study provides a framework for future research to explore the extent to which ecosystems buffer variability in inputs.
Land-use and Land-cover Changes in Pastoral Drylands: Long-term Dynamics, Economic Change, and Shifting Socioecological Frontiers in Baringo, Kenya
Authors: Greiner Clemens , Vehrs Hauke-Peter , Bollig Michael
Published: September 2021

The ongoing fragmentation of pastoral drylands is a matter of concern throughout Africa. Using the example of rangelands in northern Baringo County, Kenya, that were under uniform pastoral use until the late twentieth century, we trace land-use and land-cover changes (LULCCs) since the 1980s. Based on ethnographic, historical, and remote sensing data, we show how bush encroachment and dryland farming have led to the increasing modification and conversion of formerly open rangelands and the diversification of livelihoods. These LULCC dynamics are related to and driven not only by internal processes of socioeconomic change (e.g., sedentarization, changing rangeland management practices, growing markets for small stock, increasing stratification and cultural differentiation) but also by ecological processes such as wildlife defaunation and ecological invasions. Based on our findings, we suggest that a socioecological approach to Kopytoff’s notion of the internal African frontier can be helpful in framing these LULCC-related dynamics.
Defense Suppression through Interplant Communication Depends on the Attacking Herbivore Species
Authors: Marmolejo Laura O. , Thompson Morgan N. , Helms Anjel M.
Published: September 2021

In response to herbivory, plants emit volatile compounds that play important roles in plant defense. Herbivore-induced plant volatiles (HIPVs) can deter herbivores, recruit natural enemies, and warn other plants of possible herbivore attack. Following HIPV detection, neighboring plants often respond by enhancing their anti-herbivore defenses, but a recent study found that herbivores can manipulate HIPV-interplant communication for their own benefit and suppress defenses in neighboring plants. Herbivores induce species-specific blends of HIPVs and how these different blends affect the specificity of plant defense responses remains unclear. Here we assessed how HIPVs from zucchini plants (Cucurbita pepo) challenged with different herbivore species affect resistance in neighboring plants. Volatile “emitter” plants were damaged by one of three herbivore species: saltmarsh caterpillars (Estigmene acrea), squash bugs (Anasa tristis), or striped cucumber beetles (Acalymma vittatum), or were left as undamaged controls. Neighboring “receiver” plants were exposed to HIPVs or control volatiles and then challenged by the associated herbivore species. As measures of plant resistance, we quantified herbivore feeding damage and defense-related phytohormones in receivers. We found that the three herbivore species induced different HIPV blends from squash plants. HIPVs induced by saltmarsh caterpillars suppressed defenses in receivers, leading to greater herbivory and lower defense induction compared to controls. In contrast, HIPVs induced by cucumber beetles and squash bugs did not affect plant resistance to subsequent herbivory in receivers. Our study shows that herbivore species identity affects volatile-mediated interplant communication in zucchini, revealing a new example of herbivore defense suppression through volatile cues.
Adoption patterns over time: a replication
Authors: Appel Gil , Muller Eitan
Published: September 2021

Based on new data, we replicate Mahajan et al.’s (1990) paper on adopter categories and Goldenberg et al.’s (2002) paper on saddles and offer explanations and extensions. We use a new dataset to replicate the results, namely, the U.S. Consumer Technology Association’s Sales & Forecasts, which provides longitudinal data on numerous consumer electronic products. Goldenberg, Libai, and Muller utilized the same source for 1999, while we use the updated 2021 report for the adopter category as well as the saddle replication, thus employing the same data source for both studies. We find that in the adoption of consumer electronics, there are fewer saddles, and these saddles are shorter and shallower in 2021 than they were in 1999. Regarding adopter categories, we break the data down by decades and show that, while the early adopter categories just barely decelerated over the six decades of our analysis, the average growth of the new dataset is much faster, with the peak occurring considerably sooner than that of the earlier data.
A Delay-Tolerant Data Congestion Avoidance Algorithm for Enterprise Cloud System Based on Modular Computing
Authors: Yuan Kaiyin , Wang Feng , Marszalek Zbigniew
Published: September 2021

Traditional large-scale enterprise cloud system has the problem of large delay. Therefore, a delay tolerant data congestion avoidance algorithm based on modular computing is designed. The resource allocation rules of rbfr strategy in traditional enterprise cloud are improved to change the traditional interactive overall mode and make it modular.Using modular thinking to construct the data congestion control algorithm, mainly in the control layer to achieve the model, through the introduction of ant colony algorithm in modularization, the design of delay tolerant data congestion avoidance algorithm is realized. In order to verify the algorithm’s congestion avoidance effect, comparative experiments are designed. Experimental results show that the packet loss rate of large enterprise cloud system under this algorithm is lower than that of traditional delay tolerant data congestion avoidance algorithm.
The TWEAK/Fn14/CD163 axis—implications for metabolic disease
Authors: Ratajczak Wiktoria , Atkinson Sarah D , Kelly Catriona
Published: September 2021

TWEAK (tumor necrosis factor-like weak inducer of apoptosis) is a member of the TNF superfamily that controls a multitude of cellular events including proliferation, migration, differentiation, apoptosis, angiogenesis, and inflammation. TWEAK control of these events is via an expanding list of intracellular signalling pathways which include NF-κB, ERK/MAPK, Notch, EGFR and AP-1. Two receptors have been identified for TWEAK – Fn14, which targets the membrane bound form of TWEAK, and CD163, which scavenges the soluble form of TWEAK. TWEAK appears to elicit specific events based on the receptor to which it binds, tissue type in which it is expressed, specific extrinsic conditions, and the presence of other cytokines. TWEAK signalling is protective in healthy tissues, but in chronic inflammatory states become detrimental to the tissue. Consistent data show a role for the TWEAK/FN14/CD163 axis in metabolic disease, chronic autoimmune diseases, and acute ischaemic stroke. Low circulating concentrations of soluble TWEAK are predictive of poor cardiovascular outcomes in those with and without diabetes. This review details the current understanding of the TWEAK/Fn14/CD163 axis as one of the chief regulators of immune signalling and its cell-specific role in metabolic disease development and progression.
The fittingness of emotions
Authors: Naar Hichem
Published: September 2021

We often assess emotions as appropriate or inappropriate depending on certain evaluative aspects of the world. Often using the term ‘fittingness’ as equivalent to ‘appropriateness’, many philosophers of emotion take fittingness assessments of emotions to be a broadly representational matter. On this sort of view, an emotion is fitting or appropriate just in case there is a kind of representational match between the emotion and the object, a matching analogous to truth for belief (or veridicality for perception). This view provides an account of the relationship between emotion and value that many have found plausible. In this paper, I argue that the fittingness of emotions should not be understood in representational terms. Rather, as is common in the literature on fittingness, we should interpret the notion in normative terms. After providing four arguments against the representational interpretation, and for a normative interpretation, of emotional fittingness, I discuss two ways to develop the normative picture of emotional fittingness. I also clarify the relevant issues that will have to be tackled by philosophers of emotion in the future, issues which cannot be tackled without attending to action theory and the philosophy of normativity.
Generation and characterization of a Myh6-driven Cre knockin mouse line
Authors: Huang Xinyan , Yan Lei , Kou Shan , Meng Jufeng , Lu Zhengkai , Lin Chao-Po , Liu Chen , Zhang Hui
Published: September 2021

Gene deletion by the Cre-Loxp system has facilitated functional studies of many critical genes in mice, offering important insights and allowing deeper understanding on the mechanisms underlying organ development and diseases, such as heart development and diseases. In this study, we generated a Myh6-Cre knockin mouse model by inserting the IRES-Cre-wpre-polyA cassette between the translational stop codon and the 3′ untranslated region of the endogenous Myh6 gene. By crossing knockin mice with the Rosa26 reporter lines, we found that Myh6-Cre targeted cardiomyocytes at the embryonic and postnatal stages. In addition, we were able to inactivate the desmosome gene Desmoplakin (Dsp) by breeding Myh6-Cre mice with a conditional Dspflox knockout mouse line, which resulted in embryonic lethality during the mid-term pregnancy. These results suggest that the new Myh6-Cre mouse line can serve as a robust tool to dissect the distinct roles of genes involved in heart development and function.
SARS-CoV-2 adsorption on suspended solids along a sewerage network: mathematical model formulation, sensitivity analysis, and parametric study
Authors: Kostoglou Margaritis , Petala Maria , Karapantsios Thodoris , Dovas Chrysostomos , Roilides Emmanuel , Metallidis Simeon , Papa Anna , Stylianidis Efstratios , Papadopoulos Agis , Papaioannou Nikolaos
Published: September 2021

Accounting for SARS-CoV-2 adsorption on solids suspended in wastewater is a necessary step towards the reliable estimation of virus shedding rate in a sewerage system, based on measurements performed at a terminal collection station, i.e., at the entrance of a wastewater treatment plant. This concept is extended herein to include several measurement stations across a city to enable the estimation of spatial distribution of virus shedding rate. This study presents a pioneer general model describing the most relevant physicochemical phenomena with a special effort to reduce the complicated algebra. This is performed both in the topology regime, introducing a discrete-continuous approach, and in the domain of independent variables, introducing a monodisperse moment method to reduce the dimensionality of the resulting population balance equations. The resulting simplified model consists of a large system of ordinary differential equations. A sensitivity analysis is performed with respect to some key parameters for a single pipe topology. Specific numerical techniques are employed for the integration of the model. Finally, a parametric case study for an indicative—yet realistic—sewerage piping system is performed to show how the model is applied to SARS-CoV-2 adsorption on wastewater solids in the presence of other competing species. This is the first model of this kind appearing in scientific literature and a first step towards setting up an inverse problem to assess the spatial distribution of virus shedding rate based on its concentration in wastewater.
Deconstruction of Discernment in Child Euthanasia
Authors: Pusterla Elia R.G.
Published: September 2021

Belgian law on child euthanasia uses the concept of discernment to bestow the right to die to minors. Jacques Derrida’s deconstruction of oppositional logic grasps the ambiguity of this use of discernment and generally challenges the alleged force of a textual sign meaningfully to differentiate itself from its different and meaninglesselse. This alleged ability to discern the presence of discernment impinges the truth-value of the distinction between worthy/unworthy lives. The resultingundecidabilitymorally suggests the respect forothernessand promotes the moral value of the suspension of arbitrary judgment (epokhē) and, in so doing, de facto converges towards the praxis of the doctrine of the sanctity of life that embraces the ‘life is always quality’ argument.
The rule of law and the EU’s response mechanisms in case of violation: a Romanian Case Study
Authors: Dumbrava Horatius
Published: September 2021

The judgment of the European Court of Justice of 18 May 2021 obliges Romania to review the judicial reform of 2017 – 2019. Otherwise the European Commission may activate the safeguard mechanisms provided by Arts. 37 and 38 of the Treaty of Accession of Romania to the European Union.

The jurisprudence of the Court of Justice in all preliminary rulings relating to this Romanian judicial reform will have effects and will be an essential benchmark regarding the mechanisms established by the European Commission for all Member States relating to the rule of law - namely, the Rule of Law Mechanism and Regulation no. 2020/2092.
Developing genetic counselling services in an underdeveloped healthcare setting
Authors: Ciucă Andrada , Moldovan Ramona , Băban Adriana
Published: September 2021

Genetic counselling services are well established in North America, Western Europe and Australia. In other regions, genetic counselling services are still emerging. Where this is the case, an in-depth understanding of the main stakeholders’ needs, challenges and opportunities will inform the changes and innovations required to bring genetic counselling closer to the community. The present study explored the needs and challenges of patients, family members and professionals with a view to setting up a cancer genetic counselling service in Romania. In order to get a comprehensive outlook, key stakeholders were interviewed using data source triangulation method. Thirty-four semi-structured interviews were conducted (13 patients, 11 family members and 10 professionals). Thematic analysis was used to explore and identify needs, barriers and opportunities in emerging cancer genetic counselling services. Three major themes were identified: (1) the “Needs” theme mainly focuses on various types of support that participants mentioned wanting: psychosocial, peer and additional support; (2) the “Challenges” theme includes aspects related to limited access to healthcare, lack of integrated services and pressure on the families; (3) the “Hopes” theme highlights the wish for integrated healthcare and an empathic rapport with healthcare providers. Our findings highlighted the main needs, challenges and hopes the patients, family members and professionals have and provides the groundwork for setting up cancer genetic counselling services.
Hybrid Triboelectric-Electromagnetic Nanogenerators for Mechanical Energy Harvesting: A Review
Authors: Vidal João V. , Slabov Vladislav , Kholkin Andrei L. , dos Santos Marco P. Soares
Published: September 2021

Motion-driven electromagnetic-triboelectric energy generators (E-TENGs) hold a great potential to provide higher voltages, higher currents and wider operating bandwidths than both electromagnetic and triboelectric generators standing alone. Therefore, they are promising solutions to autonomously supply a broad range of highly sophisticated devices. This paper provides a thorough review focused on major recent breakthroughs in the area of electromagnetic-triboelectric vibrational energy harvesting. A detailed analysis was conducted on various architectures including rotational, pendulum, linear, sliding, cantilever, flexible blade, multidimensional and magnetoelectric, and the following hybrid technologies. They enable highly efficient ways to harvest electric energy from many forms of vibrational, rotational, biomechanical, wave, wind and thermal sources, among others. Open-circuit voltages up to 75 V, short-circuit currents up to 60 mA and instantaneous power up to 144 mW were already achieved by these nanogenerators. Their transduction mechanisms, including proposed models to make intelligible the involved physical phenomena, are also overviewed here. A comprehensive analysis was performed to compare their respective construction designs, external excitations and electric outputs. The results highlight the potential of hybrid E-TENGs to convert unused mechanical motion into electric energy for both large- and small-scale applications. Finally, this paper proposes future research directions toward optimization of energy conversion efficiency, power management, durability and stability, packaging, energy storage, operation input, research of transduction mechanisms, quantitative standardization, system integration, miniaturization and multi-energy hybrid cells.
Continuous synthesis of bromoalkyl glycosides by Fischer glycosylation in a microreactor
Authors: Jung Jessica , Kaiser Lars , Deigner Hans-Peter , Schmidt Magnus S.
Published: September 2021

In this study, bromoalkyl glycosides were successfully synthesized in microreactor scale by Fischer glycosylation. Yields between 24 and 40% after purification were achieved using various acidic catalysts and conditions. In some experiments, yields 180% higher than with previously known methods could be achieved. This study showed also that reversed-phase flash chromatography is more successful than normal-phase flash chromatography for the purification of bromoalkyl glycosides. Furthermore, longer bromoalcohols were shown to be more compatible than shorter bromoalcohols under these reaction conditions.
Ebselen, a multi-target compound: its effects on biological processes and diseases
Authors: Lu Qianqian , Cai Yi , Xiang Chenyan , Wu Tao , Zhao Ying , Wang Jun , Wang Helen , Zou Lili
Published: September 2021

Ebselen is a well-known synthetic compound mimicking glutathione peroxidase (GPx), which catalyses some vital reactions that protect against oxidative damage. Based on a large number of in vivo and in vitro studies, various mechanisms have been proposed to explain its actions on multiple targets. It targets thiol-related compounds, including cysteine, glutathione, and thiol proteins (e.g., thioredoxin and thioredoxin reductase). Owing to this, ebselen is a unique multifunctional agent with important effects on inflammation, apoptosis, oxidative stress, cell differentiation, immune regulation and neurodegenerative disease, with anti-microbial, detoxifying and anti-tumour activity. This review summarises the current understanding of the multiple biological processes and molecules targeted by ebselen, and its pharmacological applications.
Blind disturbance separation and identification in a transitional boundary layer using minimal sensing
Authors: Gluzman I. , Cohen J. , Oshman Y.
Published: September 2021

A novel approach is presented for identifying disturbance sources in wall-bounded shear flows. The underlying approach models the flow state, as measured by sensors embedded in the flow, as a mixture of disturbance sources. The degenerate unmixing estimation technique is adopted as a blind source separation technique to recover the separate sources and their unknown mixing process. The efficiency of this approach stems from its ability to isolate any, a priori unknown, number of sources, using two sensors only. Furthermore, by adding a single additional sensor, the method is expanded to also determine the propagation velocity vector of each of the isolated sources, based on sensor readings from three sensors appropriately located in the flow field. Theoretical guidelines for locating the sensors are provided. The power of the method is demonstrated via computer simulations and wind-tunnel experiments. The numerical study considers disturbances comprising discrete Tollmien–Schlichting waves and wave packets. Linear stability theory is used to model source mixtures acquired by sensors placed in a Blasius boundary layer. The experimental study investigates the flow over a flat plate, with hot wires as sensors, and a loudspeaker and plasma actuators as source generators. Based on numerical and experimental demonstrations, it is believed that the new approach should prove useful in various applications, including active control of boundary layer transition from laminar to turbulent flow.
Tecnología lítica de las primeras sociedades del extremo sur de Sudamérica
Authors: Skarbun Fabiana , Cueto Manuel E. , Frank Ariel D. , Paunero Rafael S.
Published: September 2021

Presentamos una revisión exhaustiva de la información disponible sobre la tecnología lítica de las sociedades finipleistocénicas de la Meseta Central de Santa Cruz (Patagonia, Argentina). Hasta el momento esta sólo había sido estudiada de manera fragmentaria. Abordamos de forma integrada los procesos de producción y consumo registrando tres aspectos de la tecnología: disponibilidad de materias primas en los paisajes donde se encuentran los sitios; estructura de los conjuntos y sus características tecnomorfológicas; y funcionalidad de los instrumentos. Los resultados indican que la disponibilidad de recursos líticos habría influenciado en la organización de la tecnología, en la elección de los lugares donde se desarrollaron distintas prácticas sociales, y en el modo en que se estructuraron las actividades de producción y consumo entre distintos sitios. Se prefirió el diseño de instrumentos unifaciales sobre soportes generalizados, pero también se elaboraron diseños que implicaron mayor inversión de trabajo. Así, las formas de uso y las funciones a las cuales fueron destinados los instrumentos influyeron en otros aspectos de la tecnología.
Gaia EDR3 parallaxes of type I X-ray bursters and their implications on the models of type I X-ray bursts: A generic approach to the Gaia parallax zero point and its uncertainty
Authors: Ding Hao , Deller Adam T. , Miller-Jones James C. A.
Published: September 2021

Light curves of photospheric radius expansion (PRE) bursts, a subset of type I X-ray bursts, have been used as standard candles to estimate the ‘nominal PRE distances’ for 63% of PRE bursters (bursters), assuming PRE burst emission is spherically symmetric. Model-independent geometric parallaxes of bursters provide a valuable chance to test models of PRE bursts (PRE models) and can be provided in some cases by Gaia astrometry of the donor stars in bursters. We searched for counterparts to 115 known bursters in the Gaia Early Data Release 3 and confirmed 4 bursters with Gaia counterparts that have detected (

$\gt\!3\,\sigma$

, prior to zero-point correction) parallaxes. We describe a generic approach to the Gaia parallax zero point as well as its uncertainty using an ensemble of Gaia quasars individually determined for each target. Assuming the spherically symmetric PRE model is correct, we refined the resultant nominal PRE distances of three bursters (i.e. Cen

$\textrm{X}-4$

, Cyg

$\textrm{X}-2$

, and

$4\textrm{U}\,0919-54$

) and put constraints on their compositions of the nuclear fuel powering the bursts. Finally, we describe a method for testing the correctness of the spherically symmetric PRE model using parallax measurements and provide preliminary results.
Host plant ranges of fruit flies (Diptera: Tephritidae) in Madagascar
Authors: Rasolofoarivao H. , Raveloson Ravaomanarivo L. H. , Delatte H.
Published: September 2021

Agriculture is one of the major farming activities, representing 32% of the gross domestic product of Madagascar and 74.3% of the population is involved in this activity. Fruit flies of the Tephritidae family are considered as the most destructive pests for agriculture in the country, nevertheless, few data exist on host plants and distribution of those pests. In the present study, we address those questions by conducting a large survey between November 2016 and July 2018 across the six agroecological regions of Madagascar. Fruit and vegetable were sampled from 198 plant species (wild and cultivated) and represented 37,965 fruits from all regions of Madagascar. The infestation index ranged from 0.06 to 538.46 pupae/kg, the infestation percentage was up to 54.84% in some samples, 63 plant species were considered as host of Tephritidae. Twelve fruit fly species were identified, seven of which were previously described as endemic, five species could be considered as widespread (altitudinal gradients between 1 and 1634 m asl) and major pests in Madagascar:Ceratitis malgassa(23 plant species from 12 families),Neoceratitis cyanescens(16 plant species from one family),Bactrocera dorsalis(18 plant species from 12 families),Dacus demmerezi(ten plant species from one family),Dacus vertebratus(six species from one family). Those results are of importance for implementation of control measures.
The conservation and ecology of the British Virgin Islands endemic tree, Vachellia anegadensis
Authors: Bárrios Sara , Dufke Maria , Hamilton Martin , Cowan Robyn , Woodfield-Pascoe Nancy , Dalsgaard Bo , Hawkins Julie , Clubbe Colin
Published: September 2021

Numerous island species have gone extinct and many extant, but threatened, island endemics require ongoing monitoring of their conservation status. The small tree Vachellia anegadensis was formerly thought to occur only on the limestone island of Anegada in the British Virgin Islands and was categorized as Critically Endangered. However, in 2008 it was discovered on the volcanic island of Fallen Jerusalem, c. 35 km from Anegada, and in 2018 it was recategorized as Endangered. To inform conservation interventions, we examined the species’ distribution, genetic population structure, dependency on pollinators and preferred habitat, and documented any threats. We found V. anegadensis to be locally widespread on Anegada but uncommon on Fallen Jerusalem and established that geographical location does not predict genetic differentiation amongst populations. Vachellia anegadensis produces the highest number of seed pods when visited by animal pollinators, in particular Lepidoptera. Introduced animals and disturbance by humans appear to be the main threats to V. anegadensis, and in situ conservation is critical for the species’ long-term survival.
Host phylogeny and ecology, but not host physiology, are the main drivers of (dis)similarity between the host spectra of fleas: application of a novel ordination approach to regional assemblages from four continents
Authors: Krasnov Boris R. , van der Mescht Luther , Matthee Sonja , Khokhlova Irina S.
Published: September 2021

We investigated the patterns of phylogenetic and functional (dis)similarity in the species composition of host spectra between co-habitating generalist flea species in regional assemblages from four continents (Europe, Asia, North America and Africa) using a recently developed ordination approach (Double Similarity Principal Component Analysis). From the functional perspective, we considered physiological [body mass and basal metabolic rate (BMR)] and ecological (shelter depth and complexity) host traits. We asked (a) whether host phylogeny, physiology or ecology is the main driver of (dis)similarities between flea host spectra and (b) whether the patterns of phylogenetic and functional (dis)similarity in host spectra vary between flea assemblages from different continents. Phylogenetic similarity between the host spectra was highest in Africa, lowest in North America and moderate in Europe and Asia. In each assemblage, phylogenetic clusters of hosts dominating in the host spectra could be distinguished. The functional similarity between the host spectra of co-occurring fleas was low for shelter structure in all assemblages and much higher for body mass and BMR in three of the four assemblages (except North America). We conclude that host phylogeny and shelter structure are the main drivers of (dis)similarity between the host spectra of co-habitating fleas. However, the effects of these factors on the patterns of (dis)similarity varied across continents.
Effective incentives for increasing COVID-19 vaccine uptake
Authors: Salali Gul Deniz , Uysal Mete Sefa
Published: September 2021

In this study, we examined the relative effectiveness of prestige-based incentives (vaccination of an expert scientist/president/politician/celebrity/religious leader), conformist incentives (vaccination of friends and family) and risk-based incentives (witnessing death or illness of a person from the disease) for increasing participants' chances of getting vaccinated with respect to their coronavirus disease 2019 (COVID-19) vaccine intention. We conducted a cross-cultural survey using demographically representative samples from the UK (n = 1533), USA (n = 1550) and Turkey (n = 1567). The most effective incentives in all three countries were vaccination of an expert scientist, followed by vaccination of friends and family members and knowing someone dying from the disease. Vaccination of an expert scientist was significantly more effective at increasing vaccine intention than any other incentive. Vaccine incentives, regardless of the incentive type, were much less effective for those who originally refused the COVID-19 vaccine than for those who were hesitant to receive the vaccine. Although the percentage of vaccine-hesitant participants was highest in Turkey, the mean effectiveness scores of incentives were also the highest in Turkey, suggesting that an informed vaccine promotion strategy can be successful in this country. Our findings have policy applicability and suggest that positive vaccination messages delivered by expert scientists, vaccination of friends and family and risk-based incentives can be effective at increasing vaccine uptake.
Grociana piccola: a rare example of Republican military fortifications in Italy
Authors: Bernardini Federico , Horvat Jana , Vinci Giacomo , Berden Tina , Lavrenčič Lucija , Liccioli Lucia , Lubritto Carmine
Published: September 2021

Recent investigations at Grociana piccola, a site in northeastern Italy consisting of two sub-rectangular fortifications, offer the rare opportunity to investigate Early Roman military architecture outside the Iberian peninsula. Excavations have revealed an inner rubble masonry rampart dated to the 2nd c. BCE by associated pottery, mainly amphora remains. This date suggests that the fortification was in use during the first Roman conquest and/or later campaigns of the 2nd c. BCE, providing one of the earliest and smallest examples of a military fort. The fort's ramparts were built using the same building technique as much larger 2nd-c. BCE military camps. Another trench uncovered the northeastern corner of the outer rampart and a probable tower or artillery platform which can be connected to a temporary camp built during the mid-1st c. BCE.
Building Calculated Uncertainty: Cedric Price’s Interaction Centre
Authors: Aragüez Marcela
Published: September 2021

As his friend Niall Hobhouse claimed, Cedric Price ‘wasn’t really an architect, but a social critic to the left of the Left who stumbled on the post-war ruins of modernism’.1 The role of Price’s unbuilt legacy for Western architectural culture has been praised extensively, with a special emphasis on the unorthodox nature of both his practice and academic contributions.2 Succeeding generations have found inspiration in Price’s personal view of the architectural profession, his work being positioned often within radical and utopian approaches yet involving a committed social agenda. The social role of architecture was for Price tightly linked to the capacity of the built environment to be adapted by its users. Buildings should be understood as temporary commodities, malleable objects with a short lifespan dictated by their usefulness for the community. Conceived as infrastructures, unbuilt projects such as the famous Fun Palace, Potteries Thinkbelt, or Magnet were formulated as productive objects with a profound commitment for socially regenerating the contexts into which they were to be inserted.
T-type folded SIW-based leaky-wave antennas with wide scanning angle and low cross-polarization
Authors: Xiao Shixiao , Yang Lianwu
Published: September 2021

In this paper, a leaky-wave antenna (LWA) with wide scanning angle and low cross-polarization is proposed based on a T-type folded substrate-integrated waveguide (FSIW). Transverse slots with a sinusoidal distribution pattern are etched on the surface of the FSIW so that transmission lines with slow-wave characteristics can excite and radiate −1 order harmonics. The length of the transverse slot affects the dispersion characteristics of the transmission line, and the sinusoidal modulation period controls the operating range of the LWA. In the frequency range of 8.3–15 GHz, the proposed LWA achieves a wide scanning ranging from backward −42° to forward +68° continuously. The cross-polarization of the beam is also kept at less than −30 dB during this scanning. A prototype is fabricated and measured to confirm the design, and the measured results show an agreement with the simulated one.