bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of the effects of cellular therapy on reproduction of the conditioned passive avoidance reflex in rats with quinoline-induced model of Huntington’s disease
Authors: Stavrovskaya Alla V. , Novosadova Ekaterina V. , Yamshchikova Nina G. , Olshansky Artem S. , Gushchina Anastasiya S. , Konovalova Eugeniya V. , Grivennikov Igor' A. , Illarioshkin Sergey N.
Published: February 2025

Introduction. The model involving injection of quinolinic acid (QA) into the rat striatum simulates many clinical and morphological characteristics of Huntingtons disease (HD). Searching for effective treatment methods is rather topical because of the fatality of HD. One of such methods is to create a neuroprotective environment to slow down the current degenerative process and/or replace dead neurons. In particular, this can be performed by transplantation of cells capable of undergoing neuronal differentiation and integration into the proper structural and functional brain networks.
Objective. To assess effectiveness and safety of transplantation of neural progenitors differentiated from induced pluripotent stem cells (iPSCs) harvested from a healthy donor into the striatum with QA-induced model of HD.
Materials and methods. The effects of neurotransplantation on reproduction of the conditioned passive avoidance reflex were studied in rats with the model of HD induced by injection of QA into the caudate nuclei of the striatum. In the study group (n=8), human neural progenitors (1106 per 10 l of normal saline unilaterally, on the injured side) derived from iPSCs harvested from a healthy donor were injected into the caudate nuclei as the transplanted material; normal saline was injected in the control group. The conditioned passive avoidance responses were tested using the ShutАvoid 1.8.03 software on a Harvard apparatus (Panlab, Spain).
Results. When testing the reproduction of the passive avoidance responses, we found that injection of QA into the caudate nuclei of the rat brain reliably reduced the conditioned responses. Neurotransplantation of neural progenitors derived from iPSCs had a clear therapeutic effect and reinforced the passive avoidance reflex. During the entire testing period (7 days after exposure to the pain stimulus), the experimental animals either did not visit the dark compartment at all or visited it with a long latency period.
Conclusions. Experimental neurotransplantation using iPSC derivatives allowance to improve storage of trace memory in rats with QA-induced model of HD, which contributes to correction of cognitive impairments caused by administration of the neurotoxin.
The change in androgenic status in men with atherothrombotic stroke
Authors: Maksimova Marina Yu. , Moskvicheva Aleksandra S. , Chechetkin Andrey O.
Published: February 2025

Introduction. Last years special attention is paid to the age-related and gender aspects of pathogenesis of cerebrovascular disease.
Objective. To investigate the androgenic status in men with atherothrombotic stroke.
Materials and methods. There were 25 man, involved in our study (mean age 53 [45; 57]) with atherothrombotic stroke in carotid system, who were observed for the initial 48 hours since the development of neurological symptoms. The laboratory study included the estimation of blood lipid profile, carbohydrate metabolism and androginic status beside the general blood analysis and clinical urine examination. The level of free testosterone was determined by the calculation method using a nomogram according to Vermeulen (normal range 225 pmol/l or more). The levels of luteinizing hormone (normal range 2,511,0 U/l) (for exclusion primary hypogonadizme), the levels of testosterone (normal range 11,033,3 nM) and estradiol (normal range 73-206 pmol/l) were determined on an automatic chemiluminescent analyzer. Hypogonadizme was diagnosed by the level of total testosterone 12 nM or the level of free testosterone 225 pmol/l. The 14 patients (mean age 55 [49; 59]) with a chronical cerebrovascular insufficiency and without laboratory signs of lipid storage disease and carbohydrate metabolism disorder or age-related hypogonadizme composed a comparison group.
Results. The laboratory signs of androgen deficiency were detected by 72% patients with atherothrombotic stroke. Correlation link was established between androgenic deficit (total testosterone not less than 12 nM), diabetes mellitus type II (r=0.514, р=0.008) and alcohol overuse (r=0.535, р=0.033). A negative correlation relationship was established between the level of free testosterone and the body-weight index (r=0.442, р=0.022). The lowest levels of total and free testosterone, Ме 7.2 [4.2; 9.8] nM and 135 [59; 181] pmol/l respectively, were observed in a group of patients with a combination of atherothrombotic stroke and metabolic syndrome. There was no statistically significant correlation of acquired hypogonadism and blood lipid levels.
Conclusion. The laboratory signs of acquired androgenic deficit were revealed in 72% of men (mean age 53.0 [45; 57]) with atherothrombotic stroke. The lowest values of total and free testosterone were observed in patients with the syndrome of multiple metabolic disorders.
Non-motor symptoms of Parkinson’s disease: the submerged part of the iceberg
Authors: Titova Natalia V. , Chaudhuri К. Ray
Published: February 2025

James Parkinson, a physician from London, described the shaking palsy now known as Parkinsons disease (PD) in his classic essay in 1817. Parkinson noted tremor, bradykinesia, rigidity and stooped posture as the key motor features of this condition but also drew attention to sleep dysfunction, delirium, dementia, and dysautonomia, now known to be non-motor symptoms (NMS) of PD. Inspite of their importance, NMS in PD still remain under-recognised and poorly studied. Description of neuropathological correlates of NMS, as well as the development of comprehensive tools for their assessment in the early 2000s, such as the NMS questionnaire (NMSQuest) and scale (NMSS), helped to establish the importance of NMS in PD and their crucial link with quality of life. In many countries, NMS evaluation in PD is now a part of the good clinical practice standards. Studies of the integral role of NMS in PD clinical structure and natural history of PD led to the concept of PD as a complex combination of motor and non-motor manifestations with a long prodromal phase dominated by a number of NMS. The prodromal phase of PD is a major current research topic: NMS-associated biomarkers may help to identify subjects who are at risk of developing motor-phase PD and, potentially, are candidates for neuroprotective therapies. NMS burden grading with cut off values, which can be used as outcome measure in clinical trials in patients with PD, have been validated. The complex multi-neurotransmitter dysfunction of PD has been reported to manifest clinically as difeferent non-motor subtypes. Recognition of such subtypes may lead to the emergence of personalized and precision medicine approaches in PD.
Vertebrobasilar insufficiency with underlying scalenus syndrome
Authors: Maksimova Marina Yu. , Skrylev Sergey I. , Koshcheev Aleksandr Yu. , Shchipakin Vladimir L. , Sinitsyn Ivan A. , Chechetkin Andrey O.
Published: February 2025

Introduction. Compression of extracranial parts of the subclavian and vertebral arteries by neck muscles takes a certain place in the pathogenesis of cerebral circulation disorders.Objectives. To study pathogenic mechanisms of vertebrobasilar insufficiency in sсalenus syndrome and to evaluate the results of surgical treatment.Materials and methods. 68 patients with the scalenus syndrome (52 men and 16 women) aged 35 to 55 years were enrolled in the study. Patients were divided into two groups depending on the clinical manifestations: group I (38 patients) patients with compression-irritative form and the group II (30 patients) patients with reflex angiospastic form. Scalenotomy and arteriolysis were performed in group I. Scalenotomy and selective cervico-thoracic sympathectomy in group II.Results. The detailed description of the clinical picture was presented. Ultrasonic scanning with hyperabduction of the hand and Adson manoeuver revealed compression of the subclavian artery. Compression of the subclavian artery by the anterior scalene muscle was verified with the use of computed tomographic angiography. On scalenotomy it was found that autonomic vascular abnormalities were caused by the compression of the brachial plexus and subclavian artery in the interscalenum spatium and irritation of the autonomic nerves by the scalene muscles and surrounding fibrous-altered tissues. In all cases symptoms immediately diminished after the surgery.Conclusion. Hemodynamic disturbances in extravasal compression of the subclavian and vertebral arteries by the anterior scalene muscle were confirmed by the effectiveness of scalenotomy. Disappearance of vertebral artery syndrome, hand ischemia symptoms and brachial plexus compression was observed clinically.
The results of the 10-year experience of a Regional Center of care for patients with parkinsonism and extrapyramidal pathology in Yaroslavl and Yaroslavl region
Authors: Kurapin Eugeny V. , Bykanova Maria A. , Trofimova Natalya V.
Published: February 2025

Introduction. In 2007, a consultation center for patients with parkinsonism (a Regional Center) was organized in the city of Yaroslavl and Yaroslavl region. It was one of the first centers of parkinsonism over Russia.Objective. To study and compare the clinical and epidemiological features of parkinsonism in Yaroslavl and the Yaroslavl region in different periods of work of the Regional Center.Materials and methods. A total number of 6,272 patients were examined in the Regional Center in 20072017.Results. Parkinson disease (PD) was ranked first (over 80%) in the structure of parkinsonism during the whole time of activity of the Regional Center. The incidence of the syndrome of vascular parkinsonism was significantly lower in 20122017, and the dementia with Lewy bodies was significantly higher compared to 20072012. Prevalence of PD in the year of 2017 in Yaroslavl amounted to 138.14 per 100,000 population, and across Yaroslavl region until 2017 year 127.01 per 100,000 population. PD patients from towns of Yaroslavl region (82.9%) significantly prevailed in comparison with rural patients (17.1%). In 20122017, PD was diagnosed at the first stage twice as often as in the period of 20072012. In 20122017, the preliminary diagnosis matched a refined diagnosis of PD in 84% of cases.Conclusion. During recent 5 years of the activity of the Regional Center the town neurologists of Yaroslavl region identified a great number of new patients withextrapyramidal disorders. Since then significantly fewer errors has being made by the neurologists in the preliminary diagnoses and more PD has been detected at earlier stages.
Local Seismic Tomography Reveals the Crustal Structure Beneath Arraiolos (Central Portugal): Earthquake of ML 4.9 (15 January 2018)
Authors: Hamak Ines , Wachilala Piedade , Borges José , Koulakov Ivan , Araújo Alexandre , Bezzeghoud Mourad
Published: February 2025

An ML 4.9 earthquake occurred in Arraiolos, central Alentejo, on the 15 January 2018. As the mainshock was recorded as the highest magnitude in the region, a thorough investigation of the cause of this seismicity was carried out. In this study, local seismic tomography was conducted for the first time to demonstrate the importance of a uniform spatial distribution of earthquakes for obtaining accurate crustal images via seismic inversion. Two different inversions were performed using local tomographic software. The main difference between both inversions is that the first integrated the total amount of aftershocks, whereas the second one only incorporates one part. In addition, in both cases, additional events spread throughout a larger part of the region were selected. This investigation confirmed that the spatial spread of earthquakes has a greater impact on the accuracy and reliability of tomographic models than the number of earthquakes present in a region. The boundaries between the distributions of the P- and S-velocity anomalies are significantly correlated with the existing outcropping faults, revealing the probable segmentation of the São Gregorio (S.G.) fault and extension of the Santana do Campo (S.C.) fault. Moreover, a source alignment oriented west-southwest/east-northeast in the seismogenic zone was highlighted at the end of the second segment of the S.G. fault, below the main rupture zone. The velocity anomalies observed in both the P and S waves were strongly correlated with the geological formations at the surface, indicating the reliability of the seismic inversion; this contributes to a deeper comprehension of the Arraiolos seismic zone and offers valuable insights into its tectonic structure.
Efficient Perfectly Matched Layer Implementation for Seismic-Wave Modeling in 3D Spherical Coordinate Sections
Authors: Zhang Wei , Li Tong , Shen Yang , Chen Xiaofei
Published: February 2025

Perfectly matched layer (PML) has been successfully used in various wave propagation simulations in the Cartesian coordinate. But in cylindrical or spherical coordinates, the wave equations contain trigonometric terms, which make the PML equations derived by the complex stretching of the coordinate axes hard to transform back to the time domain for numerical solving. To use PML in 3D spherical sections for regional-scale seismic-wave simulation, we propose a trivial implementation of the PML in the spherical coordinate by implementing PML in a local Cartesian coordinate. The variables and spatial derivatives in the PML equations are directly expressed by the counterparts in the spherical coordinate, thus no interpolation or coordinate rotation is required during the time marching. Numerical simulations using a layered model and a slab model show that the proposed spherical-Cartesian PML implementation provides a stable PML on 3D spherical sections and can efficiently absorb waves at all the edges of the spherical section, including the convex bottom boundary.
THE MEDIATING ROLE OF JOB SATISFACTION IN THE RELATIONSHIP BETWEEN EMPATHIC LEADERSHIP AND LIFE SATISFACTION
Authors: Tortumlu Muhammet
Published: February 2025

The aim of this study is to examine the mediating role of job satisfaction in the relationship between empathetic leadership and employees' life satisfaction. The study sample consists of 382 white-collar workers based in Istanbul, employed in office-based roles across human resources, procurement, public relations, finance, and accounting departments of private enterprises. The average age of participants is 36 years. Data were collected using a demographic information form and three different self-report scales. Descriptive statistics, Pearson Correlation Coefficient, and Bootstrap Analysis were employed for data analysis to determine relationships between variables. Hayes' Process Macro was used for mediation analysis. According to the results of the research, it is understood that empathetic leadership has an effect on employee life satisfaction and job satisfaction has a mediating role in this effect.
The ways to accelerate the introduction of unmanned radiometry into precision land use systems: an algorithm for finding spatiotemporal priorities of the Non-Chernozem region
Authors: Khokhlov N.F. , Sidorov I.A. , Gudkov A.G. , Chernikov A.S. , Novichikhin E.P. , Chizhikov S.V.
Published: February 2025

The necessity to ensure the sustainable development of priority land-use technologies in the Non-Chernozem region increases the urgency of introducing new technologies for radiometric and optical remote sensing from an unmanned aerial vehicle for the rapid determination of vital parameters of the soil macrolandscape. The purpose of article to find ways to prioritize the implementation of unmanned radiometry in precision land use systems. Additional areas of demand for the development application have been revealed and justified. The prospects of introducing a new term "precise land use" into scientific circulation are shown. The priority area of the development application is reclaimed lands, as well as arrays of reclaimed lands returned to agricultural circulation in the lowland landscapes of the Russian Plain of the Central and Northwestern Economic Districts. The article results can be used as a guide in justifying the volume of radar needs for precise land use.
Study of aerosol particle sizes by sedimentation method in distilled water
Authors: Shcherbakov K.A. , Razumnaya A.V. , Makhov M.I. , Tikhonova E.A. , Chichkov M.V. , Tambura Mamadu , Cheban M.D.
Published: February 2025

One of the hidden challenges of contemporary industrial society is the accumulation of technogenic aerosol particles in the air. While precise methods exist for determining the content and dispersion of such aerosols, focusing on submicron and larger particle sizes, the presence of nanoparticles in the air complicates detection and analysis, often requiring extensive data accumulation. In this study, an alternative approach to analysis is proposed, involving aerosol deposition in water with the addition of surfactants, alongside an attempt to assess the applicability of this method in determining the size of aerosols generated by laser ablation of targets made from various metals. To investigate a method for determining the sizes of aerosol particles by depositing them in water and analyzing the resulting colloidal solution using dynamic light scattering and scanning electron microscopy. Results: The study demonstrates the feasibility of collecting aerosol samples by passing them through water and presents findings on particle coagulation and the influence of surfactants on the resulting colloidal solutions, using laser ablation on targets made of cerium metal, E110 alloy, and 08Х18Н10Т stainless steel as examples. Contemporary research focuses on understanding the impact of technogenic aerosol particles on human health. Studies highlight the potential danger posed by invisible solid nanoparticles smaller than 100 nm. However, methods for their detection and concentration measurement in the air are limited. The prevalent method involves the use of air cascade impactors, which necessitates significant time for particle accumulation and airflow pumping, especially challenging in handling radioactive materials where aerosols may contain radionuclides. Addressing this challenge requires novel approaches for capturing small aerosol samples and finer analysis methods. This study presents the results of aerosol particle deposition in liquid, specifically distilled water, followed by analysis of the resulting colloidal solution using dynamic light scattering (DLS) and scanning electron microscopy (SEM) of dried samples. Metal targets subjected to laser ablation served as aerosol sources due to their efficiency and controllability. The results demonstrate the potential of collecting aerosol samples by bubbling air through liquid to form a colloidal solution. Coagulation of nanodispersed aerosol particles in the solution was observed, forming submicron and micron-sized agglomerates detectable by DLS and SEM. Addition of surfactants in some cases allowed for the separation of agglomerates, yet did not provide information on the initial state of aerosols. Further studies should explore different liquid mediums and investigate the stability of resulting colloidal solutions.
The right of a co-owner to have guests in a shared property
Authors: Delczyk Dominik , Bury Paweł
Published: February 2025

Artykuł dotyczy uprawnienia współwłaściciela do odwiedzin gości w nieruchomości wspólnej bez uzyskiwania zgody pozostałych współwłaścicieli. W opracowaniu podjęto próbę odpowiedzi na pytanie, czy i kiedy współwłaściciel uprawniony jest do żądania od gości innego współwłaściciela opuszczenia wspólnej nieruchomości. Badania zostały przeprowadzone za pomocą metody formalno-dogmatycznej.
alchemy from hell to heaven in the divine comedy. the influence on dante of the alchemical work aurora consurgens, partially attributed to saint thomas aquinas
Authors: Balducci Marino Alberto
Published: February 2025

W Boskiej Komedii pojawia się symboliczna wizja straszliwej epidemii, która uderza w głębokie, piekielne strefy. Powiązana jest ona z niewłaściwym, oszukańczym i aroganckim wykorzystaniem nauk alchemicznych (Piekło, XXIX-XXX). Mamy tu do czynienia z prawdziwym wypaczeniem ideologicznym i techniczno-naukowym: fałszywą alchemią, która zamiast oferować pomoc naszemu światu, tworzy jedynie oszustwo oraz choroby ciała i duszy. Poprzez czyśćcową ewolucję sumienia, opartą na pokorze (Czyściec, IX), dusza ludzka rozpoczyna proces stopniowego oczyszczania się, co odpowiada prawidłowej i harmonijnej alchemii. Jest ona stopniowo doskonalona, a następnie osiąga pełnię, wytwarzając autentyczne złoto Prawdy w raju, poprzez przywołanie Gangesu, Indii i symbolu małżeństwa św. Franciszka z jego oblubienicą, czarną kobietą (Raj, XI). Dante przedstawia tę ostatnią ewokację przywołując postać św. Tomasza jako ducha z nieba. Naśladuje tu kluczową część dzieła alchemicznego: Aurora consurgens. Fragment ten można przypisać samemu Tomaszowi z Akwinu. Z Dantejskiego punktu widzenia, choroba i śmierć, jako symbole nigredo (podstawy operacji alchemicznej), nie są tylko i wyłącznie złe. Mogą one warunkować potężne i cudowne procesy ewolucyjne w kierunku nieskończonej radości spotkania z Bogiem.
Waldensian community in Daunia
Authors: Berardi Caterina Celeste
Published: February 2025

Il valdismo è l’unico movimento cosiddetto ‘ereticale’ dell’Europa medievale a essere sopravvissuto fino ad oggi, affrontando la minaccia della repressione inquisitoriale messa in atto da parte della Chiesa di Roma, ridefinendo continuamente la propria identità e diventando da fenomeno essenzialmente cittadino delle origini (Lione e le città lombarde) a rurale. Nel territorio dauno la presenza dei valdesi perdura da secoli fino ai nostri giorni; i primi stanziamenti, secondo recenti studi, risalgono presumibilmente all’età angioina (1266-1260). In questo breve contributo sono esaminate in particolare tre città che ad oggi ospitano comunità valdesi: Orsara di Puglia, Cerignola, Foggia, senza dimenticare il caso di Monteleone di Puglia.
The "New Man" in the texts of Virginie Despentes and Sandro Veronesi
Authors: Lange-Henszke Magdalena
Published: February 2025

The utopian myth of the new man is a concept present in all eras. Religion, philosophy, politics, literature, art, science perceive the new man as a perfect individual, a hero or a charismatic leader of a new humanity, liberated from all evil. In the second half of the 19th century, the revolutionary concept of individual freedom is transformed into a collective vision, the vision of a dominant race composed of "ordinary" people united by a common experience. The issue of subjectivity regains fundamental importance for humanistic thought in the second half of the 20th century, among others, thanks to the reflections proposed by feminist theory. Third-wave feminism highlighted the problem of intersectionality and detachment from women's real, everyday problems, but also proposed strategies for possible changes for men. Theorists and writers such as bell hooks and Virginie Despentes argue that men can regain the areas from which patriarchy pushed them - self-knowledge, contact with their own feelings, involvement in practices of care.
Virginie Despentes in her essay King Kong Theory points out that patriarchy is a political system that affects all members of society. Men demonstrate a profound misunderstanding of this central aspect that gives form and content to their identity and forces them to behave in a certain way, regardless of their personality needs. Virginie Despentes in The King Kong Theory and Sandro Veronesi in the novel Il Colibrì, using different methodologies, diagnose the same problems and propose similar solutions, attempting to outline the profile of the "new man". They postulate a new social order based on the needs and predispositions of the individual, not subject to the requirements of gender performance. Veronesi places the practice of care at the center of his narrative as a key element of the new masculinity. The "new man" appears as an androgynous being, able to combine care for others with the principle of pleasure.
Respect for religious freedom in church legislation
Authors: Mazurkiewicz Dariusz
Published: February 2025

900-lecie chrztu Pomorza i zachowane relacje dotyczące misji św. Ottona z Bambergu skłaniają do wniosku, że przyjęcie chrześcijaństwa przez pogan było przede wszystkim wynikiem uwiedzenia prawdą Ewangelii, jednak nie bez znaczenia pozostał wpływ władzy świeckiej, która zabezpieczała misję biskupa-misjonarza. W konsekwencji rodzi się pytanie, czy ustawodawca kościelny dopuszcza przy dziele ewangelizacji stosowanie metod zawierających elementy przymusu lub choćby presji zwiększającej skuteczność głoszenia Słowa Bożego. Odpowiedź na to pytanie była różna w zależności od okresu w historii Kościoła i społeczności ludzkich. Co prawda władza kościelna starała się pamiętać o stylu Chrystusa, który jedynie zaprasza do przyjaźni ze sobą, jednak upodabniając się niejednokrotnie do władzy państwowej, dla której stosowanie przymusu bywa sposobem realizacji władzy, niekiedy prawodawca kościelny wprowadzał przepisy dopuszczające przynaglanie do przyjęcia wiary. Nie wolno jednak, z dzisiejszego punktu widzenia, jednoznacznie negatywnie oceniać takiego ustawodawstwa. Było ono bowiem niejako odbiciem sposobu myślenia ówczesnych władców świeckich, dla których stosowanie form przymusu było częstym sposobem narzucania swojej woli. XX-wieczna koncepcja praw człowieka, pozwoliła jednak na nowo odkryć piękno Ewangelii, która nie narzuca się inaczej, jak tylko siłą samej prawdy. Ta idea znalazła swoje miejsce najpierw w nauczaniu ojców Soboru Watykańskiego II, a następnie w Kodeksie Prawa Kanonicznego, w którym w kan. 748 § 2 prawodawca normuje, że „Nigdy i nikomu nie wolno zmuszać żadnego człowieka do przyjęcia wiary katolickiej wbrew jego własnemu sumieniu”. W konsekwencji nakazuje również poszanowanie wolności religijnej przy udzielaniu sakramentów oraz zobowiązuje biskupów i misjonarzy do powstrzymywania się od wszelkich form przymusu przy głoszeniu Ewangelii. Należy zatem zauważyć, że aktualne prawodawstwo kościelne bardziej niż w poprzednich wiekach akcentuje wolność człowieka w przyjmowaniu wiary.
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Authors: Palumbo Gianni Antonio
Published: February 2025

Il contributo mira a indagare le fonti del personaggio di Argante, principale difensore di Gerusalemme nella Liberata e successivamente nella Conquistata. Il processo imitativo messo in atto da Tasso può essere considerato un significativo esempio di mellificazione. Le Furie, i Giganti (in particolar modo Nembroth), Ahcille, Turno, Mezenzio, Numano, Capaneo, il Pompeo del lucaneo Bellum civile rivivono in questo campione di immanità, che ostenta disprezzo per il divino e assomma in sé alcune caratteristiche del Plutone/Satana del concilio infernale del quarto canto. Palumbo analizza il personaggio e i suoi rapporti con Clorinda e Tancredi, con particolare attenzione alle scelte lessicali di Tasso e alle reti metaforiche. L’ultima sezione del saggio considera rapidamente la storia redazionale della figura di Argante e la sua fortuna, con accenni alla sua presenza nel melodramma, come ad esempio nel caso del Rinaldo di Händel), ma anche all’influenza che tale figura potrebbe aver avuto nell’immaginario leopardiano.
Innovative Applications of Nanoparticles in Cancer Detection and Therapy
Authors: Parhizkari Mohadeseh
Published: February 2025

This paper investigates the role of gold nanoparticles (GNPs) in cancer diagnosis and treatment from a biometric perspective. Gold nanoparticles are recognized as crucial tools in biomedicine due to their unique properties, including controllable size, chemical stability, and the ability to conjugate with various biomolecules. This study employs data from the Web of Science to conduct a biometric analysis of related articles, examining research trends, scientific collaborations, and practical applications of GNPs in cancer diagnosis and treatment. The findings indicate that GNPs can be used as contrast agents in medical imaging techniques such as CT and MRI, enabling early cancer detection through their ability to target cancer cells. Additionally, GNPs can serve as drug carriers to deliver anti-cancer drugs precisely to target cells, enhancing treatment efficacy while minimizing unwanted side effects. The advantages of GNPs over other nanoparticles, such as high chemical stability and lower toxicity, are also highlighted. Despite significant advancements, further research is needed to understand molecular mechanisms, evaluate long-term effects, and improve GNP production methods. The results of this study demonstrate that gold nanoparticles have a high potential for improving cancer diagnosis and treatment, thereby contributing to the betterment of patient quality of life.
Impacto social del Covid-19 y situación de las personas migradas en Euskadi (periodo 2020-2021)
Authors:   Universidad de Deusto, La Spina Encarnación
Published: February 2025

"La actual emergencia sanitaria y las medidas implementadas con motivo del COVID-19 han tenido desiguales repercusiones públicas, económicas y sociales especialmente para los colectivos y personas que se encuentran en situaciones vulnerables y marginadas, entre ellos las personas migradas. Desde el comienzo de la crisis sanitaria, ha habido un momento de máximo frenesí normativo y de implementación de políticas públicas para afrontar la excepcionalidad de la situación. Sin embargo, el impacto social, los efectos y desafíos futuros que plantea esta situación en cada territorio han sido diferentes. Así ocurre, en el territorio del País Vasco, precisamente, el objetivo de este trabajo es hacer un diagnóstico de situación sobre cómo ha afectado la pandemia para garantizar la protección de las personas migradas en el territorio de Euskadi. Para ello, se presta especial atención a la incidencia de la pandemia en el ámbito del acceso y garantía de la educación, la salud y los ingresos por empleo y las prestaciones sociales desde marzo 2020 hasta septiembre 2021.

Esta monografía recoge los resultados obtenidos en un primer proyecto piloto de la Clínica Jurídica Loiola (2020-2021) y un proyecto de investigación competitivo (2021-2022). En ella han participado los profesores y estudiantes de la Clínica Jurídica Loiola de la Facultad de Derecho e investigadores del Instituto de Derechos Humanos Pedro Arrupe de la Universidad de Deusto. Todo ello, ha sido posible gracias a la financiación obtenida en la Convocatoria Aristos Mundus 2021 «Impacto de COVID-19 en los derechos de las personas migradas en CAPV y C. de Madrid (2020-2022): Un análisis de investigación en Clínicas Jurídicas», ref. ACM2021_04(01/05/2021-31/07/2022) así como del Programa Ramón y Cajal del Ministerio de Ciencia e Innovación ref. RYC 2016-19465.
Filosofía, política y lenguaje en conversación con la academia: Tomo I
Authors: Montero González Martha Soledad , Páez Guzmán Esaú Ricardo , Raffin Marcelo , López Cristina , Trina Miguel Ángel , Osorio Tamayo Daniel Ernesto , Barreto Chica Omaira , Bula Caraballo Germán Ulises , Rodríguez García Hernán Ferney , García Salazar Edwin , Ríos Padilla Joséphine Aruma
Published: February 2025

La idea de reunir y presentar en este libro los avances de las investigaciones que se llevan a cabo al interior del grupo de investigación Filosofía, Educación y Pedagogía, tiene que ver con el propósito, entre otras cosas, de tener un registro del trabajo y las voces que año tras año dan cuenta del desarrollo del Proyecto de Investigación-Formación de nuevos investigadores. De manera que aquí el lector podrá encontrarse con investigaciones que, en algunos casos, presentan avances iniciales, en otros casos, señalan los desarrollos o el cierre de sus procesos de producción. Investigaciones que van definiendo problemas, estableciendo límites y construyendo caminos para dar respuestas a las preocupaciones que surgen en los campos de la educación y la formación, la historia, la filosofía, la política y el lenguaje; preocupaciones que, dada la especificidad de las ciencias sociales, cruzan un conjunto de disciplinas que permiten dar cuenta de los diferentes objetos de estudio. Es en ese territorio en el que nos movemos.
The impact of domestic policy on the formation of national identification of the East Slavic population of Austria in the 1840s-1890s
Authors: Konovalov D.
Published: February 2025

The paper studies the formation of national identification of the East Slavic population of Austria in the context of domestic policy in the 1840–1890s. The study demonstrates the formation of the national idea of the Eastern Slavs in the Austrian Empire and its transformation from a cultural and educational form to a political one.
Mortality in the Southern Urals in the 1930s: male and female population
Authors: Azhigulova A.
Published: February 2025

The population size depends on a number of factors, the determining one being mortality. Mortality of the population consists of a number of reasons, both biological (age, illness) and social (material well-being). In the 1930s, socio-economic and political events took place in the Southern Urals, as well as throughout the country, such as forced industrialization, collectivization, famine of 1932-1933, which had a significant impact on mortality among the population. Significant differences in mortality rates were observed among such categories of the population as rural and urban, male and female. By the 1930s, the male population was inferior in number to the female population, which was due to losses during the First World War and the Civil War. In addition, the male population is more susceptible to injury due to employment in heavy industrial production. In turn, the female population is most vulnerable during and after pregnancy (maternal mortality). The results of the first All-Union Population Census of 1926 and the last pre-war Population Census of 1939 were used as sources on the problem under consideration. Materials from central and local archives were used to identify the movement of mortality among the population. The current population accounting, its forms, were subject to changes throughout the 1930s. In 1935, form 3 was introduced, which made it possible to assess the mortality rate and its dynamics among the male and female population. During the period under consideration, a gender imbalance is observed: in terms of population size, women predominate, in terms of mortality rates, men.
Leonid Rybakovsky’s theoretical contribution to the development of Northern demography
Authors: Fauzer V
Published: February 2025

The paper is dedicated to the memory of an outstanding scientist of our time – Doctor of Economics, Professor Leonid Leonidovich Rybakovsky, who made a significant contribution to the theory of migration, demographic policy measures, and the assessment of demographic losses during the years of political terror and forced migrations. Theoretically, his contribution to the study of the colonization of outlying territories deserves special attention, where he substantiated that the processes of colonization have clear time boundaries. The beginning is the time of the annexation of a new territory, after which it is populated by colonists - immigrants from the country that captured or annexed populated or previously empty lands to its state. The end of the colonization process is the time when the main component of the increase in the number of residents of the developed territory – resettlement – is replaced by another component – natural population growth. Since that time, normal demographic development and further development of this territory begins. For the modern period of development, the issues of population formation in the regions of the North of Russia are considered, the methodology for assessing demographic disadvantage in Russian regions and their ranking is given. Special attention is paid to the issues of training scientific personnel for the northern regions of Russia, including the Komi Republic, the names and topics of dissertations of postgraduate students and scientists who defended their candidate and doctoral dissertations in the council of L.L. Rybakovsky are given.
Modern Russian-language historiography on the attitude of the Black Hundreds organizations to the state resettlement policy in the late 1900s - 1910s
Authors: Kuricyn A.
Published: February 2025

The paper deals with the problem of the attitude of representatives of the Black Hundreds movement to the organization of the resettlement movement by the authorities of the Russian Empire in modern historiography. It is pointed out that in modern studies, special emphasis is placed on the fact that, in the opinion of the Black Hundreds, the government failed to adequately link the national issue and the organization of resettlement. Modern researchers pay close attention to the fact that, in the understanding of the right, resettlement and colonization should have become an effective mechanism for changing the ethno-demographic structure of the outskirts.
Demographic processes in the USSR during the famine of the early 1930s: historiography of the problem
Authors: Petachenko G.
Published: February 2025

The paper considers the historiography of the demographic history of the USSR in the early 1930s, highlighting the current problems of historical demography. The main focus is on key discussions about the reliability of Soviet population statistics and the scale of the demographic crisis that engulfed the country during this period, including significant population losses. The paper investigates changes in approaches to the study of this time, which range from a categorical condemnation of the Stalinist regime in the late 1980s and early 1990s to a deep understanding of the victims of Stalinism and a careful study of the demographic upheavals of the 1930s, with subsequent attempts at historical generalizations. This path reflects the evolution of historical science, moving from one-sided interpretations to a multifaceted understanding of the processes that shaped the destinies of people and entire nations during that difficult period. The demographic processes of the early 1930s in the USSR are analyzed by researchers through the prism of the famine of 1932–1933, the consequences of which were comprehensively studied in researches of the 1990s and early 2000s. However, sources such as estimated data and summary reports of the Central Department of National Economic Accounting of the USSR do not fully reflect the real picture, which emphasizes the need to take into account regional peculiarities.
A New Estimator for Shannon Entropy
Authors: Alizadeh Noughabi Hadi , Shafaei Noughabi Mohammad
Published: February 2025

In this paper we propose a new estimator of the entropy of a continuous random variable. The estimator is obtained by modifying the estimator proposed by Vasicek (1976). Consistency of the proposed estimator is proved, and comparisons are made with Vasicek’s estimator (1976), Ebrahimi et al.’s estimator (1994) and Correa’s estimator (1995). The results indicate that the proposed estimator has smaller mean squared error than considered alternative estimators. The proposed estimator is applied to a real data set for illustration.
Optimizing Asset Management by using Double Declining Balance and The KNN Algorithm
Authors: Khaera Tunnisa  , Wahyuni Ekasasmita  , Egi Fahrezi Iswan
Published: February 2025

Satker PTN is a ministry work unit whose entire income goes into the state account and is not given ownership of its assets. One of the Satker PTN in Indonesia is the Bacharuddin Jusuf Habibie Institute of Technology (ITH). ITH's operational procedures follow the rules of Satker PTN: not given asset ownership rights. The management of BMN ITH assets has not been optimal due to limited human resources which cause difficulties in the maintenance process, checking asset conditions and procurement of goods so that digitalization tools are needed that can be used to increase the efficiency of decision making and asset data analysis. This study optimizes asset management at ITH by using the depreciation method, namely the Double Declining Balance Method to determine asset depreciation. The Multilabel Classification Method uses the K-Nearest Neighbor Algorithm to classify good asset conditions, checking needs improvement. This study evaluates the depreciation of Chromebook, HDMI Cable, Electronic Plug, LCD Projector and Microphone assets over a 5-year period. Based on the results of the study, the DDB method produces a lower Final Book Value with a faster depreciation rate. The DDB method is effective in accelerating the depreciation of high-tech assets that tend to have shorter economic lives. The kNN algorithm classifies asset conditions based on historical asset lending data that includes features related to asset depreciation and usage. The results of the comparison of the kNN and Random Forest models in asset data classification are evaluated in Cross Validation, Confusion Matrix and ROC Analysis. Evaluation of the kNN Cross Validation Model with a value of k = 27 with 5 and 10 folds with an AUC value of 0.982, accuracy of 0.981, F1 score of 0.980, precision of 0.984, recall of 0.981, and MCC of 0.871. Evaluation of the Random Forest Cross Validation Model using 50 decision trees and 5 folds with an Auc value of 0.979, accuracy, F1 score, precision, recall and MCC are the same as the kNN model. The results of the kNN and Random Forest Confusion Matrices provide similar results and are a more detailed picture of prediction errors, including false positives and false negatives, which helps in understanding and improving the model. The results of the ROC Analysis evaluation show the Threshold values of the Checking, Good, Repair categories, namely 0.794, 0.259, 0.083 for kNN and 0.692, 0.247, 0.102 for Random Forest. Based on the evaluation results, this study shows that the kNN model is able to distinguish asset categories, is accurate in predicting asset status and can reduce false positives so that only assets that really need attention can be followed up. This study combines the DDB and KNN methods can be easily implemented, accelerate asset depreciation, classify asset conditions effectively, reduce repair operational costs and can optimize asset management by implementing models in asset applications.
On a two-parameter weighted geometric distribution: properties, computation and applications
Authors: Shakhatreh Mohammed , Al-Mofleh Hazem
Published: February 2025

In this article, we introduce a flexible two-parameter weighted geometric distribution characterized by its appealing properties. A key feature of this distribution is its ability to accommodate a wide range of skewness, making it particularly suitable for modeling right-skewed data. The distribution also exhibits a unimodal shape and an increasing failure rate. Several statistical measures are derived, and the distribution parameters are estimated using the method of maximum likelihood. The accuracy of these estimates is evaluated through a Monte Carlo simulation study. To demonstrate the flexibility, versatility, and practical importance of the proposed model, we analyze three real count data sets, showing its superiority over several existing models.
Geometric weighted least squares estimation
Authors: Oldenburg Reinhard
Published: February 2025

Optimal efficiency of least squares (LS) estimation requires that the error variables (residuals) have equal variance (homoscedasticity). In LS applications with multiple output variables, heteroscedasticity can even cause bias. In weighted LS, weights are chosen to compensate for differences in variance. The selection of these weights can be challenging, depending on the specific application. This paper introduces a general method, Geometric Weighted Least Squares (GWLS) estimation, which estimates weights using the inequality between the geometric and arithmetic means. A simulation study explores the performance of the method.
Descriptif technique de l’okoumé, Aucoumea klaineana
Authors: Rédacteur de la revue Bois et Forêts des Tropiques
Published: February 2025

Le descriptif technique décrit en français l’okoumé, Aucoumea klaineana, une espèce répandue en Afrique centrale. Le descriptif expose les dénominations, l’habitat et la provenance, les caractères du rondin, l’aspect du bois débité, la structure du bois, les caractères physiques, les caractères mécaniques, les caractères chimiques, les caractéristiques énergétiques, la durabilité et la préservation, l’usinage et le sciage, le séchage, l’assemblage et la finition, les utilisations, et les caractères de l’arbre.
Foresterie rurale au Sénégal – Le projet d'aménagement et de reboisement des forêts du centre-est (P.A.R.C.E.)
Authors: Montagne Pierre
Published: February 2025

L'objectif du projet P.A.R.C.E. était d'apporter des solutions au problème de la déforestation dans les zones sahéliennes, ici le Centre-Est du Sénégal, en incitant les paysans à développer eux-mêmes la forêt en milieu rural. Les objectifs du volet « foresterie rurale » du projet étaient la création de 3 000 ha de plantations familiales et communautaires dans les départements de Kaffrine et de Tambacounda, ainsi que la gestion effective du sol forestier par les paysans. Pour ce faire, des Agents de Vulgarisation et d'Animation Forestière sénégalais ont été formés. Leur mission était de faire comprendre aux populations rurales que la désertification n'était pas une fatalité, qu'elles devaient coopérer spontanément et librement, et qu'elles bénéficieraient de moyens et d'une organisation pour la suite des opérations après la fin du financement actuel. Après 5 ans d'action, on note un développement des pépinières villageoises, mais les pépinières individuelles représentent encore 30 % du total et 22 % de la production. Les taux de réussite sont de l'ordre de 50 % après 3-4 ans. Le taux pourrait certainement être amélioré.
Acessibilidade em periódicos científicos
Authors: Silva Luan Soares , Neubert Patrícia da Silva , Dias Thiago Magela Rodrigues
Published: February 2025

Introdução: Periódicos científicos desempenham um papel crucial no avanço da ciência, servindo como espaços de comunicação, acesso e disseminação da informação científica. Alinhados aos princípios do Acesso Aberto e da Ciência Aberta, devem estar disponíveis a todos, sem barreiras, incluindo às Pessoas com Deficiência (PcD). Objetivo: Analisar as abordagens, recursos e ferramentas utilizadas para promoção da acessibilidade para Pessoas com Deficiências (PcD) nos periódicos científicos. Metodologia: Trata-se de uma pesquisa descritiva, de natureza bibliográfica, que adota um método de análise mista, combinando técnicas qualitativas e quantitativas. A investigação baseou-se na análise da produção científica relacionada à acessibilidade dos periódicos em bases de dados multidisciplinares. Resultados: Foram encontradas poucas publicações que abordam o tema, predominantemente focadas em questões específicas, como a avaliação da acessibilidade de websites ou relatos de práticas adotadas por periódicos, frequentemente voltadas a deficiências específicas. As avaliações de acessibilidade realizadas foram, em sua maioria, manuais ou mistas, sendo as automáticas conduzidas por ferramentas que verificam a conformidade com os critérios de acessibilidade do W3C. Não se identificou uma ferramenta avaliadora amplamente preferida nos estudos analisados. Conclusão. O número restrito de contribuições sobre o tema e sua limitada abrangência destacam a necessidade de aprofundamento das pesquisas. Além disso, ressalta-se a primazia em incluir a acessibilidade web nas discussões sobre o Acesso Aberto, considerando sua compatibilidade com os princípios de promoção do acesso universal à informação científica.