bluuebunny/crossref_metadata_2025 huggingface dataset:
Utilizing A Practitioner-Led Action Research Study to Improve Urban Students’ College Readiness and Pursuit
Authors: YAVUZ Olcay
Published: June 2019

This practitioner-led
action research study was conducted at a high-poverty urban school and investigated
how participation in a comprehensive school program affects underrepresented
urban students’ college readiness and pursuit. Particularly, this action research
study revealed that urban students who participated in the Comprehensive
College Readiness Access and Success Program (CCRASP) have statistically
significant higher rates of SAT participation, SAT scores, FAFSA completion,
and postsecondary applications compared to other urban students who never
participated in CCRASP. As researchers seek to produce scientific knowledge
that school leaders, policy makers, school counselors and educators can use to
improve urban school systems, this action research study further solidifies
current urgencies to re-visit urban schools’ academic and counseling support
services.
7. Sınıf Öğrencilerinin Doğrular ve Açılar Konusunda Matematiksel Dil Kullanım Düzeyleri Ve Dile İlişkin Görüşleri
Authors: YILMAZ Süha , TÜRKMEN Zehra
Published: June 2019

Bu çalışmanın amacı 7. sınıf öğrencilerinin doğrular ve açılar
konusunda matematiksel dil kullanım düzeylerinin belirlenmesi ve bu düzeyin
öğrencilerin cinsiyetlerine, akademik başarılarına, matematiksel dile ilişkin
görüşlerine göre farklılık gösterip göstermediğini belirlemektir. Araştırmanın
örneklemini 2012-2013 eğitim öğretim yılında Siirt il merkezinde milli eğitime
bağlı okullarda öğrenim gören 199 7. sınıf öğrencisi oluşturmaktadır.
Araştırmada tarama modeli kullanılmış ve veri toplama aracı olarak geometri
öğrenme alanı başarı testi ve beşli likert tipi ölçek kullanılmıştır. Verilerin
analizinde ise SPSS 18.0 paket programı kullanılmıştır. Araştırmanın sonunda,
öğrencilerin matematiksel dil kullanım düzeylerinin genel olarak orta düzeyde
olduğu, cinsiyetlerine göre anlamlı bir farklılık göstermediği, akademik
başarılarında ise başarısı pekiyi olan grubun lehine farklılık gösterdiği;
matematiksel dile ilişkin görüşlerinde ise problem oluşturabilme, kavram
oluşumu ve şekle dönüştürebilme boyutlarında anlamlı farklılık olduğunu
belirlenmiştir.
Perceptions of Referendums and Democracy: The Referendum Disappointment Gap
Authors: Bowler Shaun , Donovan Todd
Published: June 2019

We examine the gap between perceptions of seeing referendums as an important democratic principle, versus perceiving how referendums are used in practice. We term this the “referendum disappointment” gap. We find support for referendums as a democratic principle is strongest among those most disaffected from the political system, and that the disaffected are more likely to perceive they are not given a say via referendums. We also find context-specific effects. Disappointment was greater in countries with higher corruption and income inequality. We also find higher disappointment among right-populist voters, those who distrusted politicians, and among people who viewed themselves at the bottom of society. Overall, these patterns reflect disappointment with democracy among sections of society who have a sense of not being heard that conflicts with how they expect democracy should work in principle.
It Depends…Different Direct Democratic Instruments and Equality in Europe from 1990 to 2015
Authors: Geißel Brigitte , Krämling Anna , Paulus Lars
Published: June 2019

Despite the popularity of direct democracy in recent decades, research on the actual output effects of popular decision-making is rare. This is especially true with regard to equality, where there are at least three major research gaps: 1) a lack of cross-national analyses; 2) insufficient investigation of the differential effects of different direct democratic instruments on equality; and 3) a failure to distinguish between different aspects of equality, i.e., socioeconomic, legal and political equality. This article takes a first step to tackle these shortcomings by looking at all national referenda in European democracies between 1990 and 2015, differentiating between mandatory, bottom-up and top-down referenda. We find that a large majority of successful direct democratic bills—regardless of which instrument is employed—are not related to equality issues. Of the remaining ones, there are generally more successful pro-equality bills than contra-equality ones, but the differences are rather marginal. Mandatory referenda tend to produce pro-equality outputs, but no clear patterns emerge for bottom-up and top-down referenda. Our results offer interesting, preliminary insights to the current debate on direct democracy, pointing to the conclusion that popular decision-making via any type of direct democratic instrument is neither curse nor blessing with regard to equality. Instead, it is necessary to look at other factors such as context conditions or possible indirect effects in order to get a clearer picture of the impacts of direct democracy on equality.
Economic Voting in Direct Democracy: A Case Study of the 2016 Italian Constitutional Referendum
Authors: Leininger Arndt
Published: June 2019

Referendums provide citizens with more control over policy. At the same time, they often entail choices over highly complex policies and are politicised along partisan lines, suggesting that partisan rather than policy considerations will guide voters’ choices. I look to the 2016 Italian constitutional referendum, which was particularly complex and polarised, as an opportunity to test for mechanisms of government accountability in a referendum. Using a national survey of voters, I show that the more negative a respondent’s evaluation of the state of the economy, the lower their likelihood to vote ‘yes’ on the government’s reform proposal. This relationship is remarkably strong: an average respondent with a very positive evaluation of the state of the economy has an 88% probability of supporting the government’s reform proposal compared to only 12% for a respondent with a very negative evaluation. The fact that economic evaluations are a strong determinant of vote choice provides evidence for the existence of an economic vote in a referendum. This further suggests that voters may treat referendums as a sort of second-order election.
The Attractiveness of a City-Centre Shopping Environment: Older Consumers’ Perspective
Authors: Kohijoki Anna-Maija , Koistinen Katri
Published: June 2019

Older consumers represent an increasingly significant customer segment for city-centre retailers. However, many intraurban centres are struggling to maintain an attractive shopping environment. This article focuses on older consumers’ (Finns, aged 64+) perceptions of the city centre with an emphasis on design and ambient elements in the external shopping environment. Using the focus-group research method, the aim is to identify what kind of elements these are and how they constitute an attractive city-centre shopping environment for older consumers. Findings from a qualitative content analysis show that an attractive city-centre shopping environment provides convenience and safety when moving around and running errands, functional and aesthetic lighting to cope with shopping, proper furnishings regarding places to rest, harmonious building architecture integrated with refreshing urban nature, and the cleanliness of the streetscape. Findings indicate that a city-centre shopping environment offers more to older consumers than a context of satisfying consumption needs. City shopping gives a reason to go outdoors and maintain social contacts. The study has implications for creating an age-friendly city centre, the shopping environment which supports older consumers’ active and independent lives.
Overcoming Barriers to Livability for All Ages: Inclusivity Is the Key
Authors: Zhang Xue , Warner Mildred E. , Firestone Stephanie
Published: June 2019

The rapid pace of population aging in cities around the world demands that planners design communities that are livable for people of all ages and abilities. In 2017, to assess progress toward this end, AARP and the International Division of the American Planning Association conducted a global survey of planners on their efforts to incorporate a livable-communityfor-all-ages approach into their work. The survey of 559 planners measured motivators, barriers, strategies for engagement and practices facilitating planners’ work on livable communities for all ages (LCA). Using the international survey, we analyze factors driving local governments’ actions to advance LCA, and factors driving outcomes incorporating a livablecommunity-for-all-ages approach in planning practices. We show how these differ between the US and non-US respondents, including how US suburbs and rural areas lag in actions toward LCA. Regression results show that local motivations such as awareness of substantial growth in older populations is a primary factor motivating local governments to take more actions. While physical design is a critical part of the solution, we find that facilitating practices and community engagement in the process are key to advancing planning for age-friendly communities. Additionally, communities that practice more traditional approaches to planning and have limited resources actually exhibit a higher level of LCA outcomes. This suggests that focusing on community engagement and facilitating practices could be a promising approach to incorporating an all age lens in planning practices.
Understanding Belonging and Community Connection for Seniors Living in the Suburbs
Authors: Jakubec Sonya L. , Olfert Marg , Choi Liza L. S. , Dawe Nicole , Sheehan Dwayne
Published: June 2019

While much has been explored about notions of both place and belonging in regard to community health of various populations, little is known of the phenomena specific to suburban dwelling seniors. More and more seniors are living in suburban neighborhoods, communities that do not tend well to the belonging needs of this population. This qualitative study sought the perspectives of suburban dwelling seniors about the role of belonging and community connection to their health and wellbeing. Informed by strengths-based approaches to community development and health, the study engaged people from three community groups of older adults in a Canadian suburb (a seniors’ recreational/social group, and two cultural groups) in group interviews concerning the topic. Discoveries included an understanding of belonging as both personal and social, and identification of facilitators and barriers to belonging at personal and systemic levels. Belonging was experienced through connection, contribution and cooperation. These findings are important to shape community engagement with seniors and to inform decision-making and program developments in areas of recreation, leisure, health services, community policing, city planning and other services.
Exploring the Experienced Impact of Studentification on Ageing-in-Place
Authors: Lager Debbie , Van Hoven Bettina
Published: June 2019

In this qualitative study we explore the experienced impact of studentification on ageing-in-place (i.e., ageing in one’s own home and neighbourhood for as long as possible). Studentification, which refers to concentrations of students in residential neighbourhoods, has been associated with deteriorating community cohesion by several authors. This can negatively affect existing neighbourhood support structures. In examining this topic, we draw on in-depth interviews with 23 independently living older adults (65+) which were conducted in a studentified urban neighbourhood in the Netherlands. Our results show how the influx of students in the neighbourhood negatively affected older adults’ feelings of residential comfort. In spite of this, none of the participants expressed the desire to move; they experienced a sense of familiarity and valued the proximity of shops, public transport and health services, which allowed them to live independently. To retain a sense of residential mastery, our participants dealt with negative impacts of studentification, at least in part, by drawing on accommodative coping strategies that weigh in broader experiences of physical and social neighbourhood change. In doing so, they rationalised and reassessed their negative experiences resulting from studentification. We discuss the implications of our findings for the development of age-friendly neighbourhoods.
MRI-PATHOLOGICAL PARALLELS WITH THE COMPLETE TUMOR RESPONSE TO NEOADJUVANT CHEMORADIATION TREATMENT OF RECTAL CANCER
Authors: Berezoskaya T. P. , Mozerov S. A. , Dayneko Ya. A. , Nevolskikh A. A. , Shavladze Z. N. , Ivanov S. A. , Kaprin A. D.
Published: June 2019

Purpose of the study. To study the patterns of forming an MRI picture of a complete pathological morphological response (pCR) of colorectal cancer a er neoadjuvant chemoradia on therapy (NHLT) based on comparisons with the pathomorphological picture.

 Patients and methods. Among 130 patients with locally advanced colorectal cancer who received a combined treatment with NHL at A. Tsyb MRRC clinic — a Branch of HMRRC of the Ministry of Health of the Russian Federation within the period 2012–2017 thirteen patients were selected for the study, in whom pCR was achieved, according to the pathological analysis of surgical specimen. MRI was performed on all patients before the NHLT and atier the end (atier 6–10 weeks) of treatment. We analyzed the MRI ﬁ ndings from case histories (prospective assessment) on degree of tumor regression (mrTRG) using a ﬁ ve-point grading scale. Ten of these patients had MRI examinations available for re-review (retrospective assessment), which allowed for a qualitate ve assessment of the signal intensity in T2 mode on a nominal scale, according to which low, medium, moderately elevated and high MR signals were discerned; signal localization was determined relative to the intestinal lumen with conditional selection of the inner and outer layer of the wall, and the outer contour was charactezied (smooth or uneven due to hypointense spicules). The obtained data on the localization of the MR signal of varying intensity were compared with the data of the pathological description of the operating drugs.

Results. A prospective MRI assessment of pCR in 77% of cases corresponded to TRG2 and in 92% — y N0. Macroscopically, the pCR in all patients had an appearance of an ulcerative defect of the intestinal wall, to which on T2-WI in 80% of cases corresponded to a moderately elevated MR signal from the inside of the wall, due to necroti c changes and granulations, and in 100% of cases — a low MR signal from the outer layer of the intestinal wall, caused by a more mature connective tissue, the outer contour in 50% of cases was tight due to the desmoplastic reaction; hypo-intensive inclusions corresponded to lime deposits, and “mucous lakes” — inclusions with high signal intensity and clear contours.

Conclusion The features of forming MRI picture of the pCR are due to a range of radiation pathomorphosis manifestations, including destructive, regenera ve and inﬂ ammatory processes in the tumor stroma.
IMPROVING THE QUALITY OF PROSTATE TRANSURETHRAL RESECTION IN PATIENTS WITH BENIGN PROSTATIC HYPERPLASIA THROUGH INTRAOPERATIVE TRANSRECTAL ULTRASOUND MONITORING OF THE REMOVED TISSUE VOLUME
Authors: Filimonov V. B. , Vasin R. V. , Sobennikov I. S.
Published: June 2019

Purpose of the study. To improve the quality of prostate transurethral resection by means of intraoperative ultrasound monitoring of the removed tissue volume.

Patients and methods. The study included 92 patients who, according to indications, underwent prostate transurethral resection. Patients were divided into 2 groups. The 1st group included patients (n = 50) operated on using the method of monitoring the removed tissue volume, proposed in the study. The average age of patients in this group was 67.4 ± 3.88 years, the average prostate volume before surgery was 59.5 ± 4.5 cm3 with a range of values from 42 cm3 to 94 cm3. The 2nd group (n = 42) included patients operated on according to the classical method of prostate transurethral resection. The average age of patients in this group was 68.1 ± 2.9 years, the average prostate volume before surgery was 53.5 ± 4.5 cm3.

Results. The average prostate volume atier surgery in patients of the 1st group was 23.2 ± 1.8 cm3. Thus, the average volume of the removed tissue was 63.2% of the prostate gland initial volume. The average prostate volume atier surgery in patients of the 2nd group was 25.6 ± 1.9 cm3 (p < 0.05). The average volume of the removed tissue was 52.1% of the prostate gland initial volume. The number of complications is comparable in groups of patients. When using the removed tissue control during surgery, it was possible to increase the resection radicality, which is reﬂ ected by a smaller average residual volume of the prostate gland (by 9.4%) atier surgery.

Conclusion. The use of ultrasonic control of the prostate adenoma removed tissue volume during prostate transurethral resection does not increase the risks of possible postoperative complications, wherein increases radicality of the performed operation.
A TWO-YEAR STUDY OF CANCEROGENIC POTENTIAL OF THE NEW OPIOID RECEPTOR ANTAGONIST ONDELOPRAN IN RATS
Authors: Kryshen K. L. , Muzhikyan A. A. , Gaidai D. S. , Zaikin K. O. , Katelnikova A. E. , Samsonov M. Yu. , Mukhametshina E. I. , Konopleva G. E. , Shipaeva E. V. , Dmitrieva A. A. , Shagiakhmetov F. S. , Popova A. O. , Makarova M. N. , Makarov V. G.
Published: June 2019

Opioid receptor antagonists are widely used for the treatment of alcohol dependence. Currently, original drug Odelepran (INN: ondelopran) with a unique binding proﬁ le to all three types of human opioid receptors (μ, κ, δ) is being developed by R-Pharm.

Aim of the study. To investigate a cancerogenic poten al of the new opioid receptor antagonist ondelopran in a twoyear study in rats Materials and methods. The study cancerogenic potencial was performed in male and female Wistar rats at the age of 8–10 weeks at the start of experiment. All animals were allocated to 8 groups. Each group consisted of 50 animals of each sex. Test item (ondelopran ﬁ lm-coated tablets, 125 mg), was administered to the animals intragastrically as a tablets suspension in 1% starch solution daily, 5 days a week for 24 months in two doses: 10 mg/kg (equivalent therapeutic dose for humans) and 100 mg/kg. Animals of control groups were administered with placebo and vehicle (1% starch solution). Clinical observation and examination of animals were conducted weekly to detect any signs of intoxication; dynamics of the body weight and registration of animal deaths were also assessed. To assess the rate of the pathological changes, the macro- and microscopic examina on of inner organs and neoplasms was conducted.

Results. During the study the mortality rates did not diﬀ er between the groups. Clinical signs ts.and symptoms of intoxication upon administration of the tested item and placebo were not observed. Neoplasms were found in the organs of all groups of animals. More than 30 variants of neoplasms were identiﬁ ed upon pathomorphological examination. The identiﬁ ed tumors are typical for rats and considered as spontaneous age-related pathology. There was no statistically signiﬁ cant diﬀ erences between groups in the total incidence of tumors.

Conclusion. To conclude the above said, the test item of the ondelopran ﬁ lm-coated tablets, 125 mg have no carcinogenic properties.
Learning Motivation as an Aspect of personality Self-Determination at the Stage of Pre-Professional Development
Authors: Egorenko T.A.
Published: June 2019

This article analyzes the problem of raising learning motivation in high school students. Proceeding from key provisions of the theory of values, self-determination and positive psychology the authors analyzed the processes which stimulate or undermine the learning motivation of high school students. The article describes the results of the study conducted in schools of Boston (United States), where high school students were enrolled in the training program at the workplace («School-to-work»). The findings revealed that teacher’s support of students’ autonomy significantly contributes to academic performance. Promoting a positive future orientation was recognized as an important component of the efficiency of an educational program. Comparative results of the study on interplay between the level of educator’s care, autonomous motivation and positive emotions to the learning process among high school students of Germany and the United States have shown that teachers who provide such support, give high school students an opportunity to make choice and take independent decisions, contribute to formation of a positive autonomous learning motivation.
Mikro Kirletici Naproksenin Atık Sulardan Spirulina platensis ile Modifiye Edilmiş Kitosan-Polivinilalkol Biyokompozitleri ile Adsorpsiyonu
Authors: SALOGLU DERTLİ Didem
Published: June 2019

Endüstriyel
atık suların içerdiği mikro ve makro kirlilikler önemli bir çevresel kirletici
kaynak olarak karşımıza çıkmaktadır. Bu nedenle, sunulan çalışmada, anti-enflamatuvar bir ilaç etken maddesi
olan naproksenin, Spirulina platensis
(SP) ile modifiye edilmiş kitosan/polivinil alkol (KTS-PVA) biyokompoziti
kullanarak atık sulardan adsorpsiyon yöntemiyle giderilmesi incelenmiştir. Farklı
oranlarda SP içeren KTS-PVA-SP biyokompozit malzemelerin sentezlenmesi için
gluteraldehit çapraz bağlayıcı olarak kullanılmış, KTS-PVA-SP biyokompozitleri,
içersindeki SP oranı %1-3 (ağırlık/ağırlık) oranlarda hazırlanmış ve tüm
biyokompozitlerin karakterizasyonu TGA, SEM, optik mikroskop ve BET analizleri
ile yapılmıştır. Adsorpsiyon ile atık sulardan naproksen giderimine adsorpsiyon
işlemine çeşitli izoterm modelleri uygulanmış ve sonuçlar değerlendirilmiştir.
Macrofungal Biodiversity of Pazar (Tokat) District
Authors: IŞIK Hakan , TÜRKEKUL İbrahim , YILDIZ Mustafa Said
Published: June 2019

This study was made to determine the macrofungi of Pazar (Tokat) district in 2011. Pazar district located to the west of Tokat province has a transition climate between the Black Sea climate and the continental climate. After field and laboratory studies, 52 species belonging to 2 divisions, 28 families and 44 genera were identified: 7 taxa belong to Ascomycota and 45 to Basidiomycota. From the detected macrofungi, 27 were edible, 17 inedible, 8 poisonous. Morchella elata, Morchella esculenta, Agaricus bisporus, Lactarius deliciosus, Lepista nuda, Marasmius oreades, Verpa bohemica are the species collected and consumed by the local people among the edible fungi.
Mısır fidelerinin büyüme ve gelişmesi üzerine progesteronun doğrudan etkisi
Authors: TÜRK Hülya
Published: June 2019

Memeli cinsiyet hormonları arasında yer alan ve bitkilerde de doğal olarak bulunan progesteron, çimlenmeden çiçeklenmeye kadar tüm bitki gelişim safhaları üzerine önemli uyarıcı etkilere sahiptir. Ancak bu hormonun etki mekanizması halen tam olarak aydınlatılamadığı gibi, sebep olduğu etkilerin de direkt olarak kendinden mi kaynaklandığı yoksa farklı yolaklar üzerinden dolaylı olarak mı gerçekleştiği halen bilinmemektedir. Bu amaçla, mevcut araştırmada progesteron reseptör antagonisti olan mifepriston kullanılmak suretiyle, progesteronun etkisinin doğrudan mı yoksa dolaylı mı olduğu belirlenmeye çalışılmıştır. 9 günlük mısır fideleri 4 gruba ayrılarak yapraklarına saf su (kontrol grubu), progesteron (0.1 µmol.L-1), mifepriston (5.8×10-5 mmol.L-1) ve progesteron + mifepriston) solüsyonları püskürtülmüş ve tüm gruplar üç gün sonra hasat edilerek çeşitli analizler yapılmıştır. Progesteron uygulaması bitkilerin kök ve yaprak uzunluları ile total klorofil ve kuru madde içeriklerinde kontrol bitkilerine kıyasla önemli artışlara sebep olurken, mifepriston uygulanan bitkilerde bu parametrelerin tamamında belirgin düşüşler kaydedildi. Progesteron ile birlikte mifepriston uygulanan bitkilerde ise kontrol bitkilerine kıyasla istatistiki olarak önemli bir değişim meydana gelmedi. Tek başına mifepriston uygulaması ise bu parametrelerde belirgin bir inhibisyona neden oldu. Tüm bu bulgular, mifepriston uygulamasının progesteronun bağlanmasını önlemek suretiyle progesteron bağlantılı metabolik faaliyetlerin gerçekleşmesine ket vurarak mısır fidelerinin büyüme ve gelişmesini inhibe ettiğini ve böylelikle progesteronun bitki metabolizması üzerine doğrudan etkiye sahip olduğunu açıkça ortaya koymaktadır.
Moleküler Dinamik Benzetim Yöntemi ile Isıtma İşlemi Sırasında Platin Metalinin Yapısal Gelişimi ve Erime Noktası Üzerine Atomlar-arası Potansiyel Etkisinin Araştırılması
Authors: ÇELTEK Murat , DÖMEKELİ Ünal , ŞENGÜL Sedat
Published: June 2019

Bu çalışmada, farklı atomlar-arası potansiyeller ve klasik moleküler dinamik (MD) benzetimleri kullanılarak, yüzey merkezli kübik (fcc) yapıya sahip platin (Pt) elementinin taban durumdan başlayıp erime noktasının hemen üzerindeki bir sıcaklık aralığındaki fiziksel özellikleri ve atomik yapısının devinimi detaylı bir şekilde incelenmiştir. Artan sıcaklığa bağlı olarak katı sistemin yapısal gelişimini analiz etmek ve erime noktasını belirlemek için çiftler dağılım fonksiyonu (PDF), enerji-sıcaklık (E-T), örgü parametresi-sıcaklık (a-T), doğrusal termal genleşme katsayı-sıcaklık (CLTE-T) eğrileri ve çift analiz yöntemi gibi analiz yöntemleri kullanıldı. Tüm potansiyeller için MD benzetiminin sonuçlarının analizinden elde edilen veriler daha önce rapor edilen deneysel veya teorik verilerle karşılaştırılmış ve tartışılmıştır. Farklı atomlar-arası potansiyellerle elde edilen sonuçlar çoğunlukla birbirleri ile tutarlı olmasına rağmen, farklılık gösterdikleri noktalar da bulunmaktadır. Özellikle, sistemin erime noktasının belirlenmesi konusunda, her bir potansiyelin farklı erime sıcaklıkları ürettiği gözlenmiştir. Tüm potansiyel enerji fonksiyonlarında ortak olarak, artan sıcaklıkla birlikte fcc yapıyı temsil eden 1421 bağlı çiftlerinin sayısı azalmış ve bu çiftlerin büyük bir bölümünün özellikle kusurlu icosahedra (deficos) ve kusurlu fcc yapıyı temsil eden 1541 ve 1431 bağlı çiftlerine dönüştüğü görülmüştür. Pt elementi için burada ele alınan potansiyellerin bazıları düşük bazıları ise yüksek sıcaklık aralığındaki fiziksel özellikleri açıklamada başarılı olurken, Sheng ve arkadaşları tarafından öne sürülen gömülü atom metot potansiyeli (EAM1) ve sıkı-bağlı (TB) potansiyelinin saf Pt elementinin geniş sıcaklık ölçeğinde ele alınan tüm özelliklerini açıklamada diğerlerine göre daha başarılı olduğu görülmüştür.
Platin ve Bakır Temelli N-Heterosiklik Karben (NHC) Komplekslerinin Antikanser Özellikleri ve Etki Mekanizmaları
Authors: AKTAŞ Aydın
Published: June 2019

Metal-N-Heterosiklik Karben (M-NHC) kompleksleri uzun yıllardır organometalik kimyada katalitik aktivite gösteren bileşikler olarak ön plana çıkmaktadırlar. Son yıllarda bu bileşiklerin biyolojik özelliklerini ön plana çıkaran çalışmalar yoğun ilgi görmektedir. Kanser çağımızın önemli bir hastalığı olup tedavisinde kullanılacak ilaçların keşfi oldukça önemlidir. Bu nedenle M-NHC komplekslerinin antikanser özellikleri ile ilgili çalışmalar önem kazanmıştır. Antikanser etki gösteren platin ve bakır temelli M-NHC kompleksleri, bu komplekslerin en önemli olanlarındandır. NHC’lere bağlı bulunan sübstitüentlerin değiştirilmesi ile M-NHC komplekslerinin antikanser aktiviteleride değişmektedir. Bu bileşiklerin antikanser etki mekanizmaları DNA mutasyonları ve Reaktif Oksijen Türleri (ROT)‘nden oluşur. Bununla beraber M-NHC komplekslerinin antikanser etki mekanizmalarını tam olarak ortaya koyacak ve yeni sentezlenecek komplekslere yol gösterecek çalışmalara ihtiyaç vardır.
Katı Atıklar için Optimum Güzergâh Tespiti ve Alansal Dağılım Haritalarının CBS Ortamında Oluşturulması: Suruç (Şanlıurfa) Örneği
Authors: ÇAKIR Mehmet Emin , DEMİR YETİŞ Ayşegül , YEŞİLNACAR Mehmet İrfan , ULUKAVAK Mustafa
Published: June 2019

Yerel
yönetimler için, katı atıkların toplanma ve taşıma işlemleri, maliyet
bakımından en yüksek paya sahiptir. Bu nedenle, bu süreçlerin iyi yönetilmesi,
maliyet, çevre ve zaman açısından büyük önem teşkil eder. Aksi durumlarda;
aşırı yakıt tüketimi, zaman israfı, amortisman gideri, çevre ve kamu sağlığı
açısından önemli problemler ortaya çıkar. Bu bağlamda çalışma; bahsedilen
hususların, Suruç Belediyesi (Şanlıurfa) özelinde irdelenmesini içermektedir.
Çalışmada katı atık toplama sistemine ait yol ağları, çalışma alanının demografik
yapısı ve bu bölgede ortaya çıkan atık miktarları ile ilgili veri setleri
oluşturulmuştur. Bu veriler yardımıyla, katı atık toplama ve taşıma
operasyonlarında, CBS tabanlı rota ve güzergâh optimizasyonu ile her mahalleye
ait optimum güzergâh tespiti
yapılmış; alansal katı atık dağılım haritaları çıkarılmış ve fayda-maliyet
ilişkisi değerlendirilmiştir.
Bazı önemli tıbbi bitkilerin antioksidan ve antikanser etkilerinin araştırılması
Authors: TOP Rabia , ERDEN Yavuz , TEKİN Suat
Published: June 2019

Tıbbi
açıdan önemli bitkiler binlerce yıldır birçok hastalığın tedavisi amacıyla
kullanılmaktadır. Buna ek olarak modern eczacılıkta birçok bitki bileşiği ilaç
ham maddesi veya yeni ilaçların yapımında önemli bir yere sahiptir. Bu çalışmada
tıbbi öneme sahip kudret narı (Momordica charantia), pepino (Solanum muricatum)
ve altın çilek (Physalis peruviana) bitkilerinin meyvelerinden elde edilen
özütlerin biyolojik etkinliklerinin ortaya konulması amaçlanmıştır. Bitkilerin
meyve özütleri %80’lik etanolde hazırlandıktan sonra toplam polifenol içeriği
Folin-Ciocaltute reaktifi kullanılarak spektrofotometrik olarak ölçüldü. Bitki
örneklerinin serbest radikal giderme etkisi DPPH serbest radikali kullanılarak
belirlendi. Özütlerin insan over ve meme kanseri hücre hatları (sıyasıyla A2780
ve MCF7) üzerine sitotoksik etkileri MTT yöntemi kullanılarak belirlendi. Bitki
örneklerindeki toplam polifenolik düzeyin en düşük 138,14±12,15 ve en yüksek
415,71±36,89 µg/gr gallik asit düzeyinde olduğu belirlendi. Bütün özütlerin
düşük seviyede antioksidan etki sergilediği saptandı. Son olarak over ve meme
kanseri hücre serilerine uygulanan özütlerin güçlü sitotoksik etki gösterdiği
belirlendi (p<0.05). Sonuçta her üç bitki örneğinin de antioksidan
etkilerinden ziyade yüksek antikanser etkiye sahip olduğunu bizlere
göstermektedir. Her üç örneğinde söz konusu kanser türleri üzerine etkilerini
aydınlatmak için ileriki çalışmalara ihtiyaç vardır.
Some Remarks on Positive Real Functions and Their Circuit Applications
Authors: ÖRNEK Bülent Nafi , DÜZENLİ Timur
Published: June 2019

In this paper, a boundary version of the Schwarz lemma has been considered for driving point impedance functions at s=0 point of the imaginary axis. Accordingly, under Z(0)=0condition, the modulus of the derivative of the Z(s)  function has been considered from below. Here, Z(alfa), c1 and c2 coefficients of the Taylor expansion of the Z(s)=beta+c1(s-alfa)+...  function have been used in the obtained inequalities. The sharpness of these inequalities has also been proved.
Böbrek-ilhamlı Algoritma ile Ayarlanan PID Kontrolör Kullanarak DC Motor Hız Kontrolü
Authors: HEKİMOĞLU Baran
Published: June 2019

DC motor hız kontrol sistemlerinin birçok endüstriyel uygulamasında, çoğunlukla oransal-integral-türevsel (PID)
kontrolörler kullanılmaktadır. Bu çalışmada, DC motor hız kontrolünün en uygun PID kontrolör parametreleri,
yani oransal (Kp), integral (Ki) ve türev (Kd) kazançları, etkin ve hızlı bir ayar yöntemi olan böbrek-ilhamlı
algoritma (Kidney-inspired Algorithm - KA) ile belirlenmektedir. Kontrol sisteminin tasarımında, kontrolör
parametrelerinin KA tarafından optimize edilebilmesi için zaman bölgesi tabanlı bir performans ölçütü
kullanılmıştır. Bu amaç fonksiyonu ile önerilen yaklaşımın performansını değerlendirmek için son yıllarda
yayımlanmış gri kurt optimizasyon (Grey Wolf Optimization - GWO) algoritması, istilacı ot optimizasyon
(Invasive Weed Optimization – IWO) algoritması ve stokastik fraktal arama (Stochastic Fractal Search – SFS)
algoritması gibi diğer modern sezgisel-üstü optimizasyon algoritmalarına dayalı yaklaşımlarla karşılaştırmalar
yapılmıştır. Simülasyon sonuçlarından, DC motorun hız kontrolü için tasarlanan KA tabanlı PID (KA-PID)
kontrolörün kapalı çevrim sisteminin aşım, yerleşme zamanı ve yükselme zamanı gibi sistem karakteristiklerini en
az iterasyonla önemli ölçüde iyileştirdiği görülmüştür. KA-PID kontrolör yaklaşımının gürbüzlük analizi de, DC
motor parametrelerindeki değişikliklerle gerçekleştirilmiştir.
Determination of Some Thermodynamic Properties of Monocarboxylic Acids using Multiple Linear Regression
Authors: ÇOLAKOĞLU HAVARE Özge
Published: June 2019

Topological
indices are the numerical descriptor of a molecular structure obtained via
molecular graph G. Topological indices are used for studying the properties of
molecules such as structure-property relationship (QSPR), structure-activity
relationship (QSAR) and structural design in chemistry, nanotechnology, and
pharmacology. Its main role is to work as a numerical molecular descriptor in
QSAR/QSPR models. Moreover, physicochemical properties such as boiling point,
enthalpy of vaporization, and stability could be envisaged by QSAR/QSPR models.
In this study, the QSPR (Quantitative Structure Property Relationship) model is
designed using the Forgotten topological index, the Forgotten coindex, the max-min
Rodeg index, and the inverse sum indeg index to predict the thermodynamic properties
of monocarboxylic acids. The relationship analysis between the thermodynamic
properties and the topological indices was done by using the multiple linear
regression method.
Prefacio
Authors: Liddicoat Anthony J.
Published: June 2019

Preface
Decolonial Responsibility within International Higher Education: Institutional Commitment and Resistance Strategies
Authors: Escobar Gómez Mariana
Published: June 2019

This article explores certain ways in which international higher education institutions can be informed by decolonial approaches. The examination is based on the author’s and other Latin American students’ analysis and discussion of their own experiences when migrating to Luxembourg for educational purposes. The study shows that despite global access to education, individual experiences within this context are not neutral. Students’ everyday experiences were influenced by international and educational inequalities. Decolonial pedagogies are here discussed as resistance strategies for teachers, and as institutional commitment practices for universities. They challenge notions of knowledge construction. Through facilitating dialogue, they deconstruct preconceptions of otherness and view students as agents of change. In addition, they promote critical self-reflection for educators and administrators to identify themselves as subjects implied in wider global dynamics.
Second and Foreign Language Pre-Service and In-Service Teacher Development to Make Intercultural Dimensions Explicit. Reflecting Through a Comparative Proposal Between France and Colombia
Authors: Gamboa Diaz Paola Andrea
Published: June 2019

This article presents the preliminary findings of a research project conducted at two universities (in France and Colombia) and based on critical reflexivity (discernment, thinking and pedagogy). Its aim is to analyze the way intercultural epistemology (approaches, notions, perspectives, practices, etc.) could be explored in order to avoid reproducing unequal socio-educational models, which prevent guaranteeing access to equitable conditions for the whole population, explicitly integrate theoretical and methodological components into higher education pre-service and in-service language teaching programs, and promote international and interinstitutional collaborative actions as ways to co-construct teaching practices based on common but critical and contextualized educational cultures. The content and discourse analysis of multimodal documents (textual, graphic or audiovisual) that highlight mental, social and discursive representations allowed me to interpret the perceptions of participants, pre-service teachers and in-service teachers registered in a Master’s degree program in language didactics or bilingual education. These perceptions confirmed that foreign language (FL) and second language (L2) classrooms as essential places of intercultural encounters and exchange of experiences where the study of local or non-local languages and idio-culture or pluri-culture gives origin to situations of alterity. People in contact are, individually and collectively, unconsciously involved in micro-intercultural and macro-intercultural interactions. Consciously explored, those micro and macro levels could help us build a bridge between discourses and practices associated with FL and L2 intercultural dimensions, as well as to the development of intercultural dimensions repertoires relevant to personal, academic and professional life.
Evaluation of scatter radiation to the thyroid gland attributable to brain computed tomography scan in Port Harcourt, Nigeria
Authors: Robinson Ebbi D. , Nzotta Christian C. , Onwuchekwa Uwa
Published: June 2019

Background: Computed tomography (CT) is an axial imaging modality that uses X-ray. The study is to determine the amount of X-radiation that reaches the thyroid glands during brain CT.Methods: A prospective study was carried out in Rivers State University Teaching Hospital’s Radiology Department with 60 participants sent for brain CT scan. A 64 slice helical GE Optima CT machine was used while radiation dose reaching the thyroid gland was measured with themoluminiscent dosimeter (TLD) chips (TLD LiF-100). The TLD chip was placed on the anterior aspects of the neck at the level of 6th cervical vertebra (C6) and held in place with adhesive tapes. The TLD chip was later sent to the radiation dosimetric laboratory for reading. Collected data was analyzed using SPSS windows version 22.0 statistical software. A descriptive statistical tool was used to determine central tendencies. Pearson correlation and linear regression analysis models were also used to evaluate correlation between variables.Results: The mean (±SD) CTDI, DLP and brain Effective Dose were 37.265±13.098mGy, 662.451±230.782mGy-cm and 1.667±0.603mSv respectively. The Scatter X-Radiation reaching the thyroid gland and resultant Effective Dose were 5.26±3.13mSv and 0.26±0.16mSv respectively. A positive correlation between brain and thyroid gland effective doses yielded a Pearson’s correlation coefficient (r) of 0.892 within a confidence interval of 0.01 (p value of 0.01) showing significant correlation.Conclusions: The amount of radiation received by the thyroid gland during brain computed tomography scan is significant. Therefore, it is pertinent to protect the thyroid gland during the procedure.
Impact of health education in improving awareness about Methicillin resistant Staphylococcus aureus in health care professionals of tertiary healthcare centre in India
Authors: Rana Priyanka , Sule Poorva Abhishek , Kulkarni Vrushali Vishal , Ubale Milind R. , Jaitpal Varun Milind
Published: June 2019

Background: Methicillin resistant Staphylococcus aureus (MRSA) is a major pathogen causing morbidity and mortality in hospital setup. Healthcare professionals (HCPs) colonized by MRSA, play a key role in transmission of this organism to the patients. Compliance of the HCPs with sanitary guidelines is fundamental to prevent nosocomial Infections. Hence, imparting education and creating awareness is the first step towards this. The aim of this study was to determine baseline knowledge about MRSA in healthcare professionals (HCPs). The further aim of the study was to assess the impact of health education on HCPs.Methods: A total of 104 participants, including 54 nurses and 50 doctors, were surveyed using pre-validated questionnaire, regarding MRSA colonization, modes of transmission, high risk areas in hospital, isolation policy, disinfection and treatment. The survey was followed by a health education session on MRSA. Thereafter a post-test questionnaire was administered to study the impact of the health education session.Results: The study sample of 104 respondents comprised of 50 doctors (48%) and 54 nurses (52%). It was found that baseline awareness regarding MRSA was lesser in the nursing staff as compared to doctors. Statistically significant positive impact of the health education session on all the HCPs was observed when paired t-test was applied. Various challenges expressed by the participants in prevention of MRSA transmission were noted.Conclusions: Due to suboptimal awareness noted in HCPs, educational programs should be conducted to bridge the gap in knowledge and perception of HCPs to prevent spread of MRSA.
Renal bone disease in patients on hemodialysis: an observational study focusing on the variation of calcium metabolism
Authors: Elahi Wajeeha , Syed Ameen Zubair , Jamil Bilal , Kamran Shahid , Adil Raheela , Qamar Nazia , Ariff Madiha , Anwar Adnan
Published: June 2019

Background: The aim of this study was to determine the disturbances in the levels of mineral in the body due to hemodialysis at different levels of parathormone levels and to assess its association with the calcium levels.Methods: Study was a cross sectional for the period of 6 months taking ethical approval. Total 255 cases were registered in this study after taking their informed consent. The cases were divided into three groups according to PTH level. Group 1 has 87 subjects with PTH level <250, group 2 has 102 subjects with PTH level 250-650 and group 3 has 66 cases with PTH level >650. The cases were taking hemodialysis for greater than 6 months and have the ages more than 18 years were included in this study. The demographic data includes age, sex dialysis related data like duration of hemodialysis, levels of calcium, phosphorus, albumin, PTH, ALP were observed.Results: Hemodialysis duration were recorded in respective three groups as 7.28±5.71, 6.26±5.56 and 6.15±4.30 days respectively  (P=0.319). Calcium was found in group 1, 8.70±0.81, in group 2, 8.39±0.89 and in group 3, 8.76±0.82 (P=0.01). PTH level in three respective group were recorded to be 123.46±74.15, 418.47±115.49 and 1314.67±1188.63 (P <0.001).Conclusions: Present study showed that significant difference was found in mineral levels in patients on hemodialysis with PTH level as well as with alkaline phosphatase level. Nevertheless, no significant difference was found with duration of dialysis and with parameter of albumin.
Course and outcomes of complicated gallstone disease in pregnancy: a single centre experience
Authors: Akhter Nihida , Mir Irfan Nazir , Manzoor Sheikh Viqar
Published: June 2019

Background: The incidence of acute abdomen during pregnancy is approximately 1 in 500 pregnancies. The incidence of symptomatic gallstone disease in pregnancy is reported in approximately 0.2-0.5 per 1,000 pregnancies. Symptoms are similar to those in the nonpregnant state. A delay in diagnosis may increase the risk of perforation. Treatment in most cases is conservative. However, recent trends, newer instrumentation and skilled personnel encourage arranging laparoscopic cholecystectomy at the time of diagnosis.Methods: This study was a retrospective study, included 117 pregnant patients with acute gallstone disease, who were treated and followed-up at Government Medical College, Srinagar, Department of General Surgery and Department of Gynae And Obstetrics, between January 2015 and April 2017.Results: The mean age of patients in our study was 28.6 years. Majority of patients 56 (47.86%) were in is trimester of pregnancy. Parity of the patients varied from 1 to 6, with a mean parity of 2.67. The presentation of majority of patients was colicky pain right upper abdomen,108 (92.30%). All patients had gallstones on USG scan.101(86.32%) patients had acute cholecystitis, while 8 (6.83%) patients had predominant features of acute pancreatitis,8(6.83%) patients had accompanying choledocholithiasis The average wall thickness of gallbladder in our patients was 4.62 mm. Majority 106 (90.59%) patients were managed conservatively. 8 (6.83%) patients underwent cholecystectomy in same admission, after failure of conservative management, 7 patients underwent laparoscopic cholecystectomy and one underwent open cholecystectomy. 3 patients (2.56%), who had features of cholangitis were managed by ERCP. The average length of hospital stay in our patient group was 8.61 days. There was one maternal death reported in our study, there were a total of 8 (6.83%) preterm deliveries.Conclusions: Symptomatic gallstone disease in pregnancy is a common surgical problem. Diagnosis during pregnancy can be difficult, majority of cases can be managed conservatively, intervention whenever indicated must be undertaken.
Disability among lung cancer patients and its predictors: a cross-sectional study in a tertiary care centre at Kolkata, India
Authors: Pal Jayita , Santra Avradip
Published: June 2019

Background: Lung cancer is one of the commonest cancer worldwide and also in India. Being a chronic disease, it is expected to result in disability during the course of the illness. Disability in turn results in deterioration of mental health and leads to poor quality of life. The present study intended to assess the degree of disability among lung cancer patients and to find out the covariates of the same.Methods: An institution based cross-sectional study had been conducted over a period of six months among lung cancer patients attending a tertiary care centre. Exit interview had been conducted with a pretested schedule after taking informed consent. Disability had been assessed by WHO Disability Assessment Schedule 2.0 (WHODAS 2.0). Data were entered and analysed in SPSS 20.0 version.Results: A total of 210 patients were recruited in this study. Half of the study population were suffering from higher level of disability. Multivariate analysis revealed degree of disability was higher among the patients who were financially dependent to others, had advanced stage of the disease and when time since diagnosis was more than one month.Conclusions: Holistic approach needs to be taken up to address this alarming issue of disability and its consequences among lung cancer patients. The approach should include various rehabilitative measures, social security schemes by the government and active involvement of non-governmental organisations.
A 5 year retrospective study on epidemiological pattern of ocular trauma
Authors: Manhas Angli , Manhas Rameshwar S. , Manhas Gaurav S. , Sharma Rishabh , Gupta Dinesh
Published: June 2019

Background: One of the delicate structure in the human body is eye and trauma to the eye is essentially a very grave matter. Major cause of preventable monocular blindness and visual impairment in the world is ocular trauma. So any injury to the eye must be deemed to be an ocular emergency and should be handled with utmost care. Despite its public health importance, there is relatively less population based data on the magnitude and risk factors for ocular trauma specially from developing countries. The objective of the study was to find out the epidemiological pattern of ocular trauma.Methods: The present study was 5 year retrospective study of all the patients who reported directly with ocular injury or referred from the casualty to the department of ophthalmology from January 2013 to January 2018. Various parameters like age, sex, mode of injury, type of injury etc. of all patients seen during this period were analyzed.Results: Total of 4192 ocular trauma patients were seen during study period. Maximum number of ocular trauma patients i.e. 1146 were seen in age group of 21-30 years. Males i.e. 3490 outnumbered females in the present study. Road traffic accidents were the most common cause of ocular trauma and accounts for 1760 cases. Most common reported ocular trauma was periorbital oedema/ecchymosis followed by laceration. Surgical intervention was done in 1660 cases whereas 2532 were managed medically.Conclusions: From present study, we may conclude that the maximum number of ocular trauma patients were seen in the age group of 21-30 years with more preponderance in males. Road traffic accidents were the most common cause of ocular trauma. The fact that the lifetime prevalence of ocular trauma is higher than that of eye diseases, which can be decreased by implementing the traffic rules with strict force and imposing heavy fine and license cancellation for drunken driving.