bluuebunny/crossref_metadata_2025 huggingface dataset:
Potenciando una mirada joven hacia el patrimonio
Authors: Granado Penín Lara , Rodríguez Álvarez Katia
Published: July 2019

El pasado mes de marzo, tuvo lugar en Gijón (Asturias) un Intercambio Juvenil con jóvenes de diversos países (Argentina, Italia, Grecia y España) que pretendió ser un acercamiento entre los jóvenes y el rico patrimonio cultural de sus regiones a través de la adquisición de habilidades relacionadas con el emprendimiento.
El papel del patrimonio en las nuevas políticas para la cultura, la ciudad y el territorio: las agendas urbanas como marco de oportunidad
Authors: Del Espino Hidalgo Blanca , Merinero Rodríguez Rafael
Published: July 2019

Texto presentación del debate número 13 de revista PH
El Patronato del Real Alcázar de Sevilla cumple 25 años
Authors: Rodríguez Rodríguez Isabel
Published: July 2019

El Real Alcázar de Sevilla, que se gestiona a través de un patronato dependiente del Ayuntamiento de Sevilla, fue creado hace 25 años y tiene entre sus cometidos todo lo relacionado con la conservación y el uso del Alcázar y de la Casa Consistorial. A lo largo de este cuarto de siglo el Patronato se ha perfilado como una herramienta ágil de gestión. En este aniversario, desde su interés por adaptarse a los nuevos tiempos, reflexiona y diseña las líneas maestras de su futuro y las comparten aquí.
PERCEPÇÕES DE PACIENTES AMPUTADOS HOSPITALIZADOS: UMA EXPLORAÇÃO QUALITATIVA DO PERÍODO PÓS-OPERATÓRIO
Authors: Lorenzetti Branco Ruy Luiz , Bender dos Santos Kadine Priscila , Tonon da Luz Soraia Cristina , Da Silva Honório Gesilani Júlia , De Medeiros Paulo Adão
Published: July 2019

Objetivo: Conhecer as percepções de pacientes amputados no período pós-operatório imediato frente às Diretrizes de Atenção à Pessoa Amputada. Métodologia: Foram realizadas 10 entrevistas com sujeitos em pós-operatório imediato de amputação de membros inferiores em um hospital público. As entrevistas foram áudio-gravadas, transcritas e analisadas pelo software Qualitative Solutions Research (QSR) Nvivo versão 11. Resultados: A entrevista intitulada “Conversa no Leito”, abordou cinco temas geradores, que revelaram por meio de suas falas, aspectos desde a reabilitação à atuação da equipe multidisciplinar no ambiente hospitalar. Os pacientes manifestaram tristeza pela perda do membro, e a família foi a principal responsável pelo empoderamento no ambiente hospitalar. Conclusão: As percepções dos pacientes evidenciaram a aplicabilidade das diretrizes no ambiente hospitalar. As diretrizes são instrumentos norteadores e servem de guia para a equipe multidisciplinar necessitando ser mais utilizada, otimizando o processo de reabilitação.Palavras-chave: Fisioterapia; Amputação; Serviço Hospitalar de Fisioterapia; Educação em saúde; Cuidados Pós-Operatórios. PERCEPTIONS OF PATIENTS HOSPITALIZED AMPUTEES: A QUALITATIVE EXPLORATION OF THE POSTOPERATIVE PERIODABSTRACT: Objective: To know the perceptions of amputees in the immediate postoperative period in front of the Guidelines for Attention to Amputees. METHODS: Ten interviews were conducted with subjects in the immediate postoperative period of lower limb amputation in a public hospital. The interviews were audio-taped, transcribed and analyzed by Qualitative Solutions Research (QSR) software. Results: The interview entitled "Conversation in the Bed", addressed five generative themes, which revealed, through their lines, aspects from rehabilitation to the performance of the multidisciplinary team in the hospital environment. Patients expressed sadness over the limb loss, and the family was primarily responsible for empowerment in the hospital setting. Conclusion: Patients' perceptions evidenced the applicability of the guidelines in the hospital environment. The guidelines are guiding instruments and serve as a guide for the multidisciplinary team needing to be more used, optimizing the rehabilitation process.Keywords: Physical Therapy Specialty; Amputation; Physical Therapy Department, Hospital; Health education; Postoperative Care.
PEMBELAJARAN INKUIRI TERBIMBING BERBANTUAN SIMULASI KOMPUTER TERHADAP HASIL BELAJAR MATERI KESETIMBANGAN KIMIA
Authors: Fitriah Leny
Published: July 2019

This research uses factorial design 2 x 2. The sample in this research is thestudents of IKIP Kimia Mataram Chemistry study program that follow theBasic Chemistry 2 course in the even semester of academic year 2013/2014with 2 homogenously distributed classes. The sample was taken by clusterrandom sampling technique. One class consists of 21 students who weretaught inquiry led by using computer simulation and other class consists of 22students with guided Inquiry. The research data are low learning result andhigh level learning result on chemical equilibrium material measured by usingtest instrument choice and essay test with content validation each 80,6% and91,7%. The measurement of the reliability of questions was obtained fromCronbach's Alpha formula with a value of 0.73 for multiple choice tests and0.914 for the essay test. Data analysis using ANOVA Two Ways test. Theresult of the research shows that: (1) Low learning result of under guidedclass students in using computer simulation is higher than guided inquiryclass without computer simulation; (2) Higher student learning result inguided inquiry class using computer simulation higher than guided inquiryclass without computer simulation. So it can be concluded that guided inquirylearning using computer learning can student improve learning outcomes inchemical equilibrium material.
Efektivitas Penerapan Strategi Everyone is a Teacher Here Untuk Meningkatkan Prestasi Siswa Kelas VIII.A SMPN 1 Gunungsari Pada Mata Pelajaran IPA
Authors: Ukir Lalu Ukir
Published: July 2019

This research was conducted at Gunungsari 1 Public Middle School with the aimof knowing the effectiveness of the use of Everyone is A Teacher Here strategy inlearning activities, so that how far the results of student learning achievementimproved by using the learning strategy. This type of research is classroomaction research (CAR) ), which is carried out by the cycle of persiklus withseveral stages, namely: planning, implementation, observation and reflection.The data in this study are student learning activities and student learningoutcomes. The results of the study showed that the application of BeajarEveryone is a Teacher Here strategy was effective to improve students' learningachievement in grade VIII.A from cycle I to cycle II with an average score of 70 ,48 in the first cycle to 77.27, and classical completeness from the first cycle tothe second cycle experienced a significant increase of 59.38 to 87.5 while theresults of the analysis of the N-Gain test were 0.32 with the moderate category.Conclusions from the results of the study this is the application of the learningstrategy Everyone is a Teacher Here effectively increases the learning activitiesof Gunungsari 1 Junior High School students in class VIII.A so that learning ismore focused, absorbs more subject matter and is more fun for students. So itcan be concluded that the application of Everyone's a Teacher Here learningstrategy can effectively improve science learning achievement of students ofGunungsari 1 Junior High School class VIII.A from cycle I to cycle II.
Pengembangan Modul Ikatan Kimia dan Bentuk Molekul Berorientasi Nature of Science Untuk Menumbuhkan Literasi Sains Siswa
Authors: Nurwanti Hifzani , Khery Yusran , Nufida Baiq Asma
Published: July 2019

This development aims to determine the characteristics and feasibility of the oNature of Science (NOS) oriented module On the Chemical Bonds andMolecular Forms subject material through the 4D stage (Define, design,develop and disseminate). This research and development is carried out up tothe stage of development (development) with adjustments based ondevelopment needs. The module prototype was validated by 2 expertvalidator, 1 practitioner validator and 10 students as limited test respondents.Quantitative data were analyzed by percentage formulas and category.Qualitative data in the form of responses and suggestions are used asconsiderations for revisions. The results of expert validation showed anaverage percentage of 92.67% with very good categories of material experts,83.34% with very good categories from product design experts and 76% withgood categories from teacher practitioners. The average response of studentsto the modul prototype is 85.1% with a very good category. This shows thatthe module that developed is feasible to proceed to a large-scale trial phase.
Efektivitas Penggunaan Biji Kelor (Moringa Oleífera, Lam) Sebagai Koagulan Untuk Menurunkan Kadar TDS dan TSS Dalam Limbah Laundry
Authors: Hak Ahsanul , Kurniasih Yeti , Hatimah Husnul
Published: July 2019

Laundry waste contains detergent which can cause water pollution because itcontains various kinds of substances that can affect various waterparameters, especially such as TDS (total dissolved solids) and TSS (totalsuspended solids). To reduce these parameters is done by the coagulationprocess which is adding moringa seed powder as coagulant. Moringa seedscan work as a coagulant because they contain an active substance, 4-alfa-4-rhamnosyloxy-benzil-isothiocyanate. The coagulation process was carried outby varying several coagulation parameters such as the size of the coagulantpowder (Al (80-100mesh) and A2 (100mesh), stirring speed (slow, medium,and fast), settling time (15, 45 and 75 minutes) and mass ratio to samplevolume (100 mg against 100, 150 and 200 mL) .The samples used in thecoagulation process were taken by grab sampling technique and thedetermination of TDS and TSS levels was carried out by the gravimetricmethod. The data showed the size of moringa seed powder coagulant, stirringspeed, settling time and coagulant mass ratio with sample volume influencethe% decrease in TDS and TSS levels, optimum conditions on coagulantpowder size> 100 mesh, moderate stirring speed, 15 minute deposition timeand coagulant mass ratio to sample volume 1: 1 ( mg / L), where% decreasein TDS is 74.07% from 270000 mg / L to 70000 mg / L and TSS of 82.14%from 56000 mg / L to 10000 mg / L.
Проблемні питання правового регулювання діяльності суб’єктів, які здійснюють охорону та захист військового майна
Authors: Melnyk Oksana , Tienshev Vyacheslav
Published: July 2019

Охорона та захист власності (майна) вимагають наявності чіткого правого регулювання. Визначення дієвих адміністративно-правових механізмів можливе лише за наявності наукового підґрунтя. Наразі в теорії адміністра-тивного права не існує класифікації суб’єктів, які здійснюють охорону та захисту військового майна. Відповідно в законодавстві України не визначено державний орган або систему органів, відповідальних за виконання функцій охорони та захисту військового майна. Дане питання вимагає запровадження чітких державних механізмів контролю за охороною та захистом військового майна, оцінки їхньої ефективності.

У статті розглядається така правова категорія, як адміністративно-правовий статус. Більш детально увага автора зупинилася на особливостях правового статусу суб’єктів, які здійснюють охорону та захист військового майна. Аналізуються такі правові категорії як компетенція, завдання, функції та повноваження, права та обов’язки, їх співвідношення між собою. Запропоновано авторське визначення понять «компетенція» та «повноваження».
Аналіз чинників, які впливають на ефективність функціонування системи тилового забезпечення Збройних Сил України
Authors: Vlasov Igor , Mechetenko Mykhaylo , Hannenko Iurii
Published: July 2019

У статті на основі проведеного аналізу функціонування системи тилового забезпечення Збройних Сил України, після оцінки загального показника, пропонуються основні напрямки розвитку та удосконалення її шляхом впровадження єдиної автоматизованої системи управління логістики. Однією з важливіших задач сучасного системного аналізу є оцінка загального показника рівня функціонування системи тилового забезпечення за сукупністю часткових показників її підсистем та параметрів. При аналізі складної системи математичний апарат, що використовується є високоефективним, але все ж являється допоміжним інструментом дослідження. З використанням методу оцінки роботи системи зазначені показники оптимізуються за критеріями своєчасності та повноти тилового забезпечення Збройних Сил України її вдосконалення, спроможності  виконувати покладені завдання у структурі сил оборони України. Важлива особливість інформаційного аналізу при вивченні системи, опрацюванні і обґрунтуванні керуючих впливів є сумісне використання як кількісної інформації, так і якісної для знаходження альтернативних важелів показників, що мають вірогідний характер для оцінки підсистем. Для підвищення ефективності системи тилового забезпечення у кризових ситуаціях застосовано метод оцінки підсистеми для удосконалення рівня функціонування системи тилового забезпечення та визначено напрямки зменшення негативного впливу недоліків в роботі системи на процес тилового забезпечення та шляхи вирішення проблемних питань.
Automatización del proceso de secado de producto húmedo, usando un método de control multivariable no paramétrico
Authors: Lopez Ortiz Hernan Alonso , García Jaimes Luis Eduardo
Published: July 2019

En este artículo se presenta el diseño e implementación de un sistema de control multivariable para un proceso productivo de secado de producto húmedo en un secador a chorro, utilizando controladores PI y desacopladores de tipo simplificado. El objetivo principal de esta implementación es hacer viable la reducción de la cantidad de producto no conforme que se genera en una compañía del sector minero, por la manipulación manual de algunas variables, por la fuerte interacción entre ellas y por el efecto de las perturbaciones en el proceso que generan pérdidas tanto en tiempo como en el producto. Para el diseño se realizó la identificación del proceso, se estimaron los controladores PI fuera de línea y, finalmente se realizó el diseño de los desacopladores. Los resultados obtenidos a escala de simulación y en el proceso real demostraron la efectividad del sistema de control diseñado.
Valoración de programas de implementación de generación distribuida en sistemas de potencia
Authors: Lopez Lezama Jesus Maria , Tamayo Carlos Andres , Sanchez Mora Martin Miguel
Published: July 2019

En este artículo se presenta una metodología para valorar programas de implementación de generación distribuida (GD) en sistemas de potencia. La valoración de los programas se hace a través de diferentes índices que consideran la cargabilidad y el perfil de tensión de la red ante diferentes escenarios operativos, como también el efecto de contingencias simples (criterio N-1). Inicialmente los índices se usan para diagnosticar el sistema e identificar elementos y escenarios operativos críticos. Posteriormente, se evalúa el efecto de la implementación de programas de GD en la red cuando esta se reparte de forma uniforme y cuando se ubica en los nodos críticos identificados en el caso base. Se realizaron varias pruebas en los sistemas IEEE de 24 y 57 barras. Los resultados muestran que la GD reduce en mayor medida la criticidad de líneas y escenarios operativos cuando esta es ubicada en nodos estratégicos.
Influence of desilication conditions on the shynthesis of herarchical zeolite Y
Authors: Villa Holguín Aída Luz , Imbachí Gamba Carlos Fernando
Published: July 2019

Hierarchical zeolites were synthesized by two methodologies, following desilication procedures of commercial zeolites. Starting from USY zeolite (Zeolyst CBV720,Si/Al=15), the effect of the amount of CTAB in the desilication media and the hydrothermal treatment time on the synthesized materials were analyzed.The results showed that the surfactant amount has a higher influence on relative crystallinity (%RC) and textural properties of the materials than synthesis time. All the samples showed a lower BET surface area compared with the starting zeolite, although mesopore surface area increased from 210.33 to 467.30 m2/g in the case of Z720-75sample. In the case of USY zeolite withSi/Al=2.6 (ZeolystCBV500),a previous dealumination with H4EDTA and anacid washingwith Na2H2EDTAsteps were included.It was found that the micropore and the mesopore surface areasincreased 13.96% and 11.23%, respectively, compared with the parent zeolite; furthermore, the %RC was 99% after treatmentprocedures.
RETRACTED: MiR-519b-3p Inhibits the Proliferation and Invasion in Colorectal Cancer via Modulating the uMtCK/Wnt Signaling Pathway
Authors: Zhang Yuexiang , Sun Miao , Chen Yusha , Li Bixun
Published: July 2019

Dysregulation of microRNAs (miRNAs) and their targeted downstream genes is involved in the carcinogenesis and progression of colorectal cancer (CRC). miR-519b-3p has been reported to play an important role in several cancers. However, its function in CRC is unclear. In this study, we detected the expression of miR-519b-3p in CRC tissues and cell lines, and determined the potential role of miR-519b-3p in cell proliferation and invasion in CRC. Also, the downstream gene of miR-519b-3p was determined. Our results showed that miR-519b-3p was notably reduced in CRC specimens and cell lines. Overexpression of miR-519b-3p inhibited the proliferation and invasion of RKO and DLD-1 cells, whereas knockdown of miR-519b-3p had the contrary effect. The ubiquitous mitochondrial creatine kinase (uMtCK) was identified as a direct target of miR-519b-3p in CRC using luciferase assay. Additionally, miR-519b-3p expression was negatively correlated with uMtCK expression in CRC specimens. Notably, the miR-519b-3p suppressed the uMtCK/Wnt signaling pathway in CRC cells, thereby suppressing CRC cell proliferation and invasion. The inhibition of uMtCK by miR-519b-3p may provide a promising option for the treatment of CRC.
Application of Multi-Dimension Input Convolutional Neural Network in Fault Diagnosis of Rolling Bearings
Authors: Zan Tao , Wang Hui , Wang Min , Liu Zhihao , Gao Xiangsheng
Published: July 2019

Aiming at the problem of poor robustness of the intelligent diagnostic model, a fault diagnosis model of rolling bearing based on a multi-dimension input convolutional neural network (MDI-CNN) is proposed. Compared with the traditional convolution neural network, the proposed model has multiple input layers. Therefore, it can fuse the original signal and processed signal—making full use of advantages of the convolutional neural networks to learn the original signal characteristics automatically, and also improving recognition accuracy and anti-jamming ability. The feasibility and validity of the proposed MDI-CNN are verified, and its advantages are proved by comparison with the other related models. Moreover, the robustness of the model is tested by adding the noise to the test set. Finally, the stability of the model is verified by two experiments. The experimental results show that the proposed model improves the recognition rate, robustness and convergence performance of the traditional convolution model and has good generalization ability.
Time Coding OTDM MIMO System Based on Singular Value Decomposition for 5G Applications
Authors: Aly Rana M. , Zaki Amira , Badawi Waleed K. , Aly Moustafa H.
Published: July 2019

For 5G and beyond cellular communication systems, new coding and modulation techniques are suggested to reach the requirements of high data rate and quality of service. In this paper, a new space-time coded orthogonal transform division multiplexing (STC OTDM) technique is proposed for 5G applications. The proposed system is used to enhance the data rate and performance of the orthogonal transform division multiplexing (OTDM) technique. The proposed system is based on using space-time coding (STC) with OTDM to increase the system diversity and consequently the system performance. The OTDM technique is based on transmitting data on orthogonal basis functions obtained from the Singular Value Decomposition (SVD) of the channel impulse response of the desired user. Various modulation techniques like QPSK, 64-QAM, and 256-QAM are investigated using different subcarriers and channel models. The simulation results show that the proposed system achieved a better performance when compared to classical and recent multicarrier techniques. The proposed technique increases the diversity gain resulting in a decrease in the fading effect of the multipath channel and an enhancement in the bit error rate (BER) performance. The proposed technique also provides a secure data transmission to the desired user as his data is sent on the basis functions extracted from his own channel impulse response that cannot be decoded by other users.
Planning and Scheduling with Uncertainty in the Steel Sector: A Review
Authors: Iglesias-Escudero Miguel , Villanueva-Balsera Joaquín , Ortega-Fernandez Francisco , Rodriguez-Montequín Vicente
Published: July 2019

The following paper proposes a study about the existing solutions for dealing with uncertainty while solving the planning and scheduling problem at steel industry manufacturing processes. The different techniques designed to cope with uncertainty in manufacturing scheduling are discussed, along with the main uncertainty factors affecting the scheduling. The paper proposes a classification for the main uncertainties affecting the steelmaking process and analyzes the existing literature about solutions for the scheduling with uncertainty in the steel sector in terms of approaches followed and uncertainty types considered. Finally, the main remarks and future challenges within this field are presented.
Evaluation of Rheological Behavior, Resistance to Permanent Deformation, and Resistance to Fatigue of Asphalt Mixtures Modified with Nanoclay and SBS Polymer
Authors: Ceccon Carlesso Gabriela , Trichês Glicério , Staub de Melo João Victor , Marcon Matheus Felipe , Padilha Thives Liseane , da Luz Lídia Carolina
Published: July 2019

Fatigue cracking and rutting are among the main distresses identified in flexible pavements. To reduce these problems and other distresses, modified asphalt mixtures have been designed and studied. In this regard, this paper presents the results of a study on rheological behavior and resistance to permanent deformation and to fatigue of four different asphalt mixtures: (1) with conventional asphalt binder (CAP 50/70); (2) with binder modified by nanoclay (3% NC); (3) with binder modified by styrene–butadiene–styrene polymer (SBS 60/85); and (4) with binder modified by nanoclay and SBS (3% NC + 2% SBS). For this analysis, the mixtures were evaluated based on complex modulus, permanent deformation tests, and fatigue tests (4PB, in the four-point bending apparatus), with the subsequent application of numerical simulations. The results obtained show a better rheological behavior related to greater resistance to permanent deformation for the mixture 3% NC + 2% SBS, which could represent an alternative for roads where a high resistance to rutting is required. Otherwise, on fatigue tests, higher resistance was observed for the SBS 60/85 mixture, followed by the 3% NC + 2% SBS mixture. Nevertheless, based on the results of the numerical simulations and considering the possibility of cost reduction for the use of the 3% NC + 2% SBS mixture, it is concluded that this modified material has potential to provide improvements to the road sector around the world, especially in Brazil.
Ballistic Head Protection in the Light of Injury Criteria in the Case of the Wz.93 Combat Helmet
Authors: Jamroziak Krzysztof , Bajkowski Marcin , Bocian Miroslaw , Polak Slawomir , Magier Mariusz , Kosobudzki Mariusz , Stepien Radoslaw
Published: July 2019

This paper discusses the general conditions relating to ballistic head protection, analyzing the risks that may occur on contemporary battlefields. A thorough literature review has enabled us to present development trends for helmets used in the largest armies in the world. The authors have focused on impacts to the helmet shell, overloading the entire helmet-protected head–neck system. The main objective of this study is to investigate the protective capability of a helmet shell when subjected to projectile–helmet contact, with contact curvature taken as being an indicator of the impact energy concentration. Blunt head trauma was estimated using backface deformation (BFD). The Wz.93 combat helmet was used for testing. Analytically, dependencies were derived to determine the scope of BFD. A five-parameter model of the helmet piercing process was adopted, thus obtaining the optimal BFD range. Verification of theoretical considerations was carried out on a specially developed research stand. In the ballistic tests, dynamic deflection of the helmet’s body was registered using a speed camera. On the impact testing stand, a fragment of the helmet was pierced, producing results in the low impact velocity range. Data have been presented on the appropriate graph in order to compare them with values specified in the relevant standard and existing literature. Our results correlate well with the norm and literature values.
Early Visual Communication: Introducing the 6000-Year-Old Buon Frescoes from Teleilat Ghassul, Jordan
Authors: Drabsch Bernadette , Bourke Stephen
Published: July 2019

The collection of 5th Millennium BCE frescoes from the Chalcolithic (4700–3700 BC) township of Teleilat Ghassul, Jordan, are vital signposts for our understanding of early visual communication systems and the role of art in preliterate societies. The collection of polychrome wall murals includes intricate geometric designs, scenes illustrative of a stratified and complex society, and possibly early examples of landscape vistas. These artworks were produced by specialists using the buon fresco technique, and provide a visual archive documenting a fascinating, and largely unknown culture. This paper will consider the place these pictorial artefacts hold in the prehistory of art.
Generalized Electric Field Equations of a Time-Varying Current Distribution Based on the Electromagnetic Fields of Moving and Accelerating Charges
Authors: Cooray Vernon , Cooray Gerald , Rubinstein Marcos , Rachidi Farhad
Published: July 2019

In several studies conducted recently, it was shown that equations pertinent to the electric and magnetic fields produced by electrical charges in motion can be used to calculate the electromagnetic fields produced by current pulses propagating along linearly restricted paths. An example includes the case of current pulses propagating along conductors and conducting channels such as lightning. In this paper, it is shown how the technique can be applied to estimate the electromagnetic fields generated by current and charge distributions moving in arbitrary directions in space. The analysis shows that, depending on the way the problem is formulated using the field equations pertinent to accelerating charges, one procedure leads to the generalized dipole equations, which are independent of the velocity of propagation of the current, and the other procedure leads to a set of equations that depend on the velocity. Using the well-tested transmission line model of lightning return strokes as an example, it is shown that both sets of field equations give rise to the same total electromagnetic field.
Numerical Modeling of Meteotsunami–Tide Interaction in the Eastern Yellow Sea
Authors: Heo Ki-Young , Yoon Jae-Seon , Bae Jae-Seok , Ha Taemin
Published: July 2019

Meteotsunamis originating from atmospheric pressure disturbances have frequently occurred in oceans worldwide and their destructive long waves have recently threatened local coastal communities. In particular, meteotsunamis occurring in the Yellow Sea caused unexpected casualties and property damage to local communities on the western coast of the Korean Peninsula in 2007 and 2008. These events attracted the attention of many engineers and scientists because abrupt extreme waves have struck several coasts and ports even under fine weather conditions. Furthermore, the Yellow Sea has the highest tide and most powerful tidal currents in the world, and consequently, meteotsunami events there could be more destructive and harmful to local coastal communities when such events occur during high tide or a critical phase with strong tidal currents. In this study, numerical experiments were conducted to identify the qualitative effect of the interaction between a meteotsunami and the tide on the generation and amplification mechanisms of meteotsunamis occurring in the Yellow Sea. In general, small-scale meteotsunamis, such as those that occur in the Yellow Sea, should be analyzed using a high-resolution modeling system because water motions can be affected by local terrain. To achieve this objective, high-resolution atmospheric modeling was conducted to reproduce the atmospheric pressure disturbances observed in the Yellow Sea; then, the generation and propagation of the meteotsunami over real topographies was simulated using a phase-resolving wave model. Both an atmospheric model (Weather Research and Forecasting Model (WRF)) and a shallow water equation model (COrnell Multigrid COupled Tsunami Model (COMCOT)) were employed to simulate the generation and transformation of the meteotsunami.
Ultimate Flexural Capacity of Reinforced Concrete Elements Damaged by Corrosion
Authors: Bossio Antonio , Imperatore Stefania , Kioumarsi Mahdi
Published: July 2019

Worldwide, steel corrosion is one of the greatest deterioration problems for reinforced concrete structures. Comparing some experimental results from literature with a complex FEM model, the present paper points out the principal aspects that characterize the static behavior of reinforced concrete (RC) elements damaged by corrosion. Moreover, the nondimensional abaci defined for some specific case studies finalized to the evaluation of the residual flexural strength of corroded elements highlight the dangerousness of the corrosion degradation if the failure of the element is governed by the steel.
A Novel AURKA Mutant-Induced Early-Onset Severe Hepatocarcinogenesis Greater than Wild-Type via Activating Different Pathways in Zebrafish
Authors: Su Zhong-Liang , Su Chien-Wei , Huang Yi-Luen , Yang Wan-Yu , Sampurna Bonifasius Putera , Ouchi Toru , Lee Kuan-Lin , Wu Chen-Sheng , Wang Horng-Dar , Yuh Chiou-Hwa
Published: July 2019

Aurora A kinase (AURKA) is an important regulator in mitotic progression and is overexpressed frequently in human cancers, including hepatocellular carcinoma (HCC). Many AURKA mutations were identified in cancer patients. Overexpressing wild-type Aurka developed a low incidence of hepatic tumors after long latency in mice. However, none of the AURKA mutant animal models have ever been described. The mechanism of mutant AURKA-mediated hepatocarcinogenesis is still unclear. A novel AURKA mutation with a.a.352 Valine to Isoleucine (V352I) was identified from clinical specimens. By using liver-specific transgenic fish overexpressing both the mutant and wild-type AURKA, the AURKA(V352I)-induced hepatocarcinogenesis was earlier and much more severe than wild-type AURKA. Although an increase of the expression of lipogenic enzyme and lipogenic factor was observed in both AURKA(V352I) and AURKA(WT) transgenic fish, AURKA(V352I) has a greater probability to promote fibrosis at 3 months compared to AURKA(WT). Furthermore, the expression levels of cell cycle/proliferation markers were higher in the AURKA(V352I) mutant than AURKA(WT) in transgenic fish, implying that the AURKA(V352I) mutant may accelerate HCC progression. Moreover, we found that the AURKA(V352I) mutant activates AKT signaling and increases nuclear β-catenin, but AURKA(WT) only activates membrane form β-catenin, which may account for the differences. In this study, we provide a new insight, that the AURKA(V352I) mutation contributes to early onset hepatocarcinogenesis, possibly through activation of different pathways than AURKA(WT). This transgenic fish may serve as a drug-screening platform for potential precision medicine therapeutics.
NS5A Gene Analysis by Next Generation Sequencing in HCV Nosocomial Transmission Clusters of HCV Genotype 1b Infected Patients
Authors: Bellocchi Maria Concetta , Aragri Marianna , Carioti Luca , Fabeni Lavinia , Pipitone Rosaria Maria , Brancaccio Giuseppina , Sorbo Maria Chiara , Barbaliscia Silvia , Di Maio Velia Chiara , Bronte Fabrizio , Grimaudo Stefania , Mazzucco Walter , Frigeri Ferdinando , Cantone Marco , Pinto Antonio , Perno Carlo Federico , Craxì Antonio , Gaeta Giovanni Battista , Di Marco Vito , Ceccherini-Silberstein Francesca
Published: July 2019

Background: The aim of the study was to investigate the intra-host variability through next-generation-sequencing (NGS) of the NS5A-gene in nosocomial transmission-clusters observed in two Italian hospitals among hepatitis C virus (HCV)-genotype-1b infected patients. Methods: HCV-sequencing was performed by Sanger-sequencing (NS3 + NS5A + NS5B) and by NGS (NS5A, MiSeq-Illumina) in 15 HCV-1b infected patients [five acute with onco-hematologic-disease and 10 (4/6 acute/chronic) with β-thalassemia]. Resistance-associated-substitutions (RAS) were analysed by Geno2pheno-algorithm. Nucleotide-sequence-variability (NSV, at 1%, 2%, 5%, 10% and 15% NGS-cutoffs) and Shannon entropy were estimated. Phylogenetic analysis was performed by Mega6-software and Bayesian-analysis. Results: Phylogenetic analysis showed five transmission-clusters: one involving four HCV-acute onco-hematologic-patients; one involving three HCV-chronic β-thalassemia-patients and three involving both HCV-acute and chronic β-thalassemia-patients. The NS5A-RAS Y93H was found in seven patients, distributed differently among chronic/acute patients involved in the same transmission-clusters, independently from the host-genetic IL-28-polymorphism. The intra-host NSV was higher in chronic-patients versus acute-patients, at all cutoffs analyzed (p < 0.05). Even though Shannon-entropy was higher in chronic-patients, significantly higher values were observed only in chronic β-thalassemia-patients versus acute β-thalassemia-patients (p = 0.01). Conclusions: In nosocomial HCV transmission-clusters, the intra-host HCV quasispecies divergence in patients with acute-infection was very low in comparison to that in chronic-infection. The NS5A-RAS Y93H was often transmitted and distributed differently within the same transmission-clusters, independently from the IL-28-polymorphism.
Long Noncoding RNAs and Stress Response in the Nucleolus
Authors: Pirogov Sergei A. , Gvozdev Vladimir A. , Klenov Mikhail S.
Published: July 2019

Long noncoding RNAs (lncRNAs) perform diverse functions in the regulation of cellular processes. Here we consider a variety of lncRNAs found in the ribosome production center, the nucleolus, and focus on their role in the response to environmental stressors. Nucleolar lncRNAs ensure stress adaptation by cessation of resource-intensive ribosomal RNA (rRNA) synthesis and by inducing the massive sequestration of proteins within the nucleolus. Different cell states like quiescence and cancer are also controlled by specific lncRNAs in the nucleolus. Taken together, recent findings allow us to consider lncRNAs as multifunctional regulators of nucleolar activities, which are responsive to various physiological conditions.
Epilepsy in Tubulinopathy: Personal Series and Literature Review
Authors: Romaniello Romina , Zucca Claudio , Arrigoni Filippo , Bonanni Paolo , Panzeri Elena , Bassi Maria T. , Borgatti Renato
Published: July 2019

Mutations in tubulin genes are responsible for a large spectrum of brain malformations secondary to abnormal neuronal migration, organization, differentiation and axon guidance and maintenance. Motor impairment, intellectual disability and epilepsy are the main clinical symptoms. In the present study 15 patients from a personal cohort and 75 from 21 published studies carrying mutations in TUBA1A, TUBB2B and TUBB3 tubulin genes were evaluated with the aim to define a clinical and electrophysiological associated pattern. Epilepsy shows a wide range of severity without a specific pattern. Mutations in TUBA1A (60%) and TUBB2B (74%) and TUBB3 (25%) genes are associated with epilepsy. The accurate analysis of the Electroencephalogram (EEG) pattern in wakefulness and sleep in our series allows us to detect significant abnormalities of the background activity in 100% of patients. The involvement of white matter and of the inter-hemispheric connection structures typically observed in tubulinopathies is evidenced by the high percentage of asynchronisms in the organization of sleep activity recorded. In addition to asymmetries of the background activity, excess of slowing, low amplitude and Magnetic Resonance (MR) imaging confirm the presence of extensive brain malformations involving subcortical and midline structures. In conclusion, epilepsy in tubulinopathies when present has a favorable evolution over time suggesting a not particularly aggressive therapeutic approach.
Growth of Multi-Layer hBN on Ni(111) Substrates via MOCVD
Authors: Siegel Gene , Gryzbowcki Gordon , Hilton Albert , Muratore Christopher , Snure Michael
Published: July 2019

In this paper we demonstrate a metal organic chemical vapor deposition (MOCVD) process for growth of few layer hBN films on Ni(111) on sapphire substrates using triethylborane (TEB) and ammonia (NH3). Ni(111) was selected as a substrate due to its symmetry and close lattice matching to hBN. Using atomic force microscopy (AFM) we find hBN is well aligned to the Ni below with in plane alignment between the hBN zig zag edge and the <110> of Ni. We further investigate the growth process exploring interaction between precursors and the Ni(111) substrate. Under TEB pre-exposure Ni-B and graphitic compounds form which disrupts the formation of layered phase pure hBN; while NH3 pre-exposure results in high quality films. Tunnel transport of films was investigated by conductive-probe AFM demonstrating films to be highly resistive. These findings improve our understanding of the chemistry and mechanisms involved in hBN growth on metal surfaces by MOCVD.
Research on Application of Non-Isolated Three-Port Switching Boost Converter in Photovoltaic Power Generation System
Authors: Liu Shuo , Gao Ying , Yang Liyong
Published: July 2019

This paper presents a non-isolated three-port switching boost converter and applies it to photovoltaic systems. The topology combines the characteristics of the switching boost network. By controlling three degrees of freedom, the ports have boost, buck, and buck-boost characteristics. It expands the three-port converter (TPC) working range with the advantages of simple structure, small size, and low cost. The operating mode and power flow direction of the TPC are determined according to the state of charge (SOC) of the energy storage system. Analyses of the working state of the topology in different working modes further verify the power flow of the system and explain its control strategy to complete the smooth switching of different working modes. Finally, the correctness of the above theory and its feasibility in photovoltaic system are verified by simulation and experiment.
Stability Analysis of Grid-Connected Photovoltaic Systems with Dynamic Phasor Model
Authors: Mahmud Md Rasel , Abdou Ahmed F. , Pota Hemanshu
Published: July 2019

The typical layout of power systems is experiencing significant change, due to the high penetration of renewable energy sources (RESs). The ongoing evaluation of power systems is expecting more detailed and accurate mathematical modeling approaches for RESs which are dominated by power electronics. Although modeling techniques based on state–space averaging (SSA) have traditionally been used to mathematically represent the dynamics of power systems, the performance of such a model-based system degrades under high switching frequency. The multi-frequency averaging (MFA)-based higher-index dynamic phasor modeling tool is proposed in this paper, which is entirely new and can provide better estimations of dynamics. Dynamic stability analysis is presented in this paper for the MFA-based higher-index dynamical model of single-stage single-phase (SSSP) grid-connected photovoltaic (PV) systems under different switching frequencies.
Experimental and Numerical Examination of Naturally-Aged Foam-VIP Composites
Authors: Biswas Kaushik , Jogineedi Rohit , Desjarlais Andre
Published: July 2019

This article describes an aging study of a foam-vacuum insulation panel (VIP) composite insulation board installed on a test wall in a natural exposure test facility through a 30-month period. Silica-based VIPs with a polymeric barrier film were used in this study. The study results showed the effectiveness of a VIP-based insulation to reduce the heat gains and losses through a wall compared to regular rigid foam insulation of the same thickness. However, the long-term performance monitoring indicated a gradual decline in the thermal performance of the foam-VIP composite. In addition, one-dimensional numerical models were created to simulate the in situ behavior of the foam-VIP composite. One model utilized constant thermal conductivities of the test wall components and another utilized temperature-dependent thermal conductivities; the latter used measurements of conductivity over temperatures ranging from −15 to 55 °C. The results of the simulations emphasized the need to use both temperature and time-dependent material properties for accurately predicting the long-term performance of VIP-based insulation systems.
Effect of Mixing Regimes on Cow Manure Digestion in Impeller Mixed, Unmixed and Chinese Dome Digesters
Authors: Jegede Abiodun O. , Zeeman Grietje , Bruning Harry
Published: July 2019

This study examines the effect of mixing on the performance of anaerobic digestion of cow manure in Chinese dome digesters (CDDs) at ambient temperatures (27–32 °C) in comparison with impeller mixed digesters (STRs) and unmixed digesters (UMDs) at the laboratory scale. The CDD is a type of household digester used in rural and pre-urban areas of developing countries for cooking. They are mixed by hydraulic variation during gas production and gas use. Six digesters (two of each type) were operated at two different influent total solids (TS) concentration, at a hydraulic retention time (HRT) of 30 days for 319 days. The STRs were mixed at 55 rpm, 10 min/hour; the unmixed digesters were not mixed, and the Chinese dome digesters were mixed once a day releasing the stored biogas under pressure. The reactors exhibited different specific biogas production and treatment efficiencies at steady state conditions. The STR 1 exhibited the highest methane (CH4) production and treatment efficiency (volatile solid (VS) reduction), followed by STR 2. The CDDs performed better (10% more methane) than the UMDs, but less (approx. 8%) compared to STRs. The mixing regime via hydraulic variation in the CDD was limited despite a higher volumetric biogas rate and therefore requires optimization.
Thermal Performance Evaluation of an Induced Draft Evaporative Cooling System through Adaptive Neuro-Fuzzy Interference System (ANFIS) Model and Mathematical Model
Authors: Baetens Jens , Van Eetvelde Greet , Lemmens Gert , Kayedpour Nezmin , De Kooning Jeroen D. M. , Vandevelde Lieven
Published: July 2019

The shift from fossil fuel to more renewable electricity generation will require the broader implementation of Demand Side Response (DSR) into the grid. Utility processes in industry are suited for this, having a large thermal time constant or buffer, and large electricity consumption. A widespread utility system in industry is an induced draft evaporative cooling tower. Considering the safety aspect, such a process needs to maintain cooling water temperature within predefined safe boundaries. Therefore, in this paper, two modelling methods for the prediction of the basin temperature of an induced draft evaporative cooling tower are proposed. Both a white box and a black box methodology are presented, based on the physical principles of fluid dynamics and adaptive neuro-fuzzy interference system (ANFIS) modelling, respectively. By analysing the accuracy of both models with a focus to cooling tower fan state changes, i.e., DSR purposes, it is shown that the white box model performs best. Fostering the idea of using such a system for DSR purposes, the concept of design for flexibility is also touched upon, discussing the thermal mass. Pre-cooling, where the temperature of the cooling water basin is lowered before a fan switch off period, was simulated with the white box model. It was shown that beneficial pre-cooling (to lower the temperature peak) is limited in time.
Phosphorus Mobilizing Enzymes of Alnus-Associated Ectomycorrhizal Fungi in an Alaskan Boreal Floodplain
Authors: Ruess Roger W. , Swanson Michaela M. , Kielland Knut , McFarland Jack W. , Olson Karl D. , Taylor D. Lee
Published: July 2019

Because of its high phosphorus (P) demands, it is likely that the abundance, distribution, and N-fixing capacity of Alnus in boreal forests are tightly coupled with P availability and the mobilization and uptake of soil P via ectomycorrhizal fungi (EMF). We examined whether Alnus shifts EMF communities in coordination with increasingly more complex organic P forms across a 200-year-old successional sequence along the Tanana River in interior Alaska. Root-tip activities of acid phosphatase, phosphodiesterase, and phytase of A. tenuifolia-associated EMF were positively intercorrelated but did not change in a predictable manner across the shrub, to hardwood to coniferous forest successional sequence. Approximately half of all Alnus roots were colonized by Alnicola and Tomentella taxa, and ordination analysis indicated that the EMF community on Alnus is a relatively distinct, host-specific group. Despite differences in the activities of the two Alnus dominants to mobilize acid phosphatase and phosphodiesterase, the root-tip activities of P-mobilizing enzymes of the Alnus-EMF community were not dramatically different from other co-occurring boreal plant hosts. This suggests that if Alnus has a greater influence on P cycling than other plant functional types, additional factors influencing P mobilization and uptake at the root and/or whole-plant level must be involved.
Why Do Farmers Grow Tobacco? A Qualitative Exploration of Farmers Perspectives in Indonesia and Philippines
Authors: Appau Adriana , Drope Jeffrey , Witoelar Firman , Chavez Jenina Joy , Lencucha Raphael
Published: July 2019

Tobacco supply remains a pressing challenge to tobacco control. Tobacco remains a dominant cash crop in many low- and middle-income countries, despite the evidence suggesting that it is not as profitable as industry claims and is harmful to health and the environment. In order to implement successful and sustainable alternative livelihood interventions, it is important to understand why farmers continue to grow tobacco. This study explores this question from the perspective of farmers in Indonesia and Philippines. This study was informed by interpretive description methodology. Data was collected through focus group discussions (FGDs) (n = 7) with farmers (n = ~60). The FGDs were audio recorded, transcribed verbatim, and then translated into English. An inductive thematic analysis of the data was conducted to identify and categorize the reason provided by participants. We identified two overarching themes: (1) perceived viability (profitability, ready market, and environmental factors) and (2) financial context. Financial context included lumpsum payments and access to financial loans and credit facilities in light of their lack of capital. These results highlight that, in addition to identifying viable alternatives to tobacco, institutional factors such as improved access to credit and well-developed supply chains are key to the successful uptake of alternative livelihoods.