bluuebunny/crossref_metadata_2025 huggingface dataset:
Outcome of Early Reversal of Intestinal Stoma: A Cross- Sectional Study
Authors: Talukdar Md. Monoarul Islam , Islam Nazia , Jalal Mohammed Tanvir , Ovi Mir Rasekh Alam , Nasrin Shamima , Sheikh Md. Shahadot Hossain
Published: August 2023

Background
Early reversal of temporary intestinal stoma might bring good clinical outcome as like as late reversal in the context of anastomotic leakage, postoperative ileus, sepsis, intraoperative bleeding etc. This may avoid stoma related morbidity & complications. This study was designed to find out the short-term outcomes of early reversal of intestinal stoma within 14 days of index surgery.
Methods
This cross-sectional observational study was conducted at the Department of Colorectal Surgery, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh. The study duration was 16 months, from March 2021 to June 2022. During this period, a total of 15 patients of either sex who underwent colorectal surgery with employment of intestinal stoma during the study period were included in the study following the inclusion and exclusion criteria. Preoperative checking of anastomotic leakage of index surgery was performed by water soluble rectal contrast imaging prior to selection of cases.
Result
The study included 15 participants with relatively even age and gender distributions. The majority of participants experienced favorable postoperative outcomes, with minimal complications. The anastomotic leak rate was 6.7%, with only one patient experiencing it out of a total of 15. However, a relatively high rate of wound infection (40%) was observed among the participants.
Conclusion
The study demonstrates that early reversal of intestinal stoma in Bangladesh may result in predominantly favorable outcomes in selected patients. However, the high rate of wound infection necessitates further investigation into the causes and implementation of effective preventive measures. Future research with larger and more diverse patient populations is needed to validate and expand upon these findings, contributing to improved surgical care and patient outcomes in Bangladesh and beyond.
Evaluation of the effectiveness of using flipped classroom in puncture skills teaching
Authors: Zhang Weihao , Jiang Miao , Zhao Wei , Li Shuai , Li Fan , Feng Feifei , Wang Yongjing , Li Yan , Liu Lan
Published: August 2023

Background
The effectiveness of flipped classroom (FC) on puncture skills in medical education is still uncertain. The purpose of this study was to assess the role of the FC model in puncture skills and investigate the acceptance and approval of FC among medical students and instructors.
Methods
A mixed quasi-experimental with randomization was conducted in September 2022 for one month, using an FC teaching method that combined instructional videos and group learning. The study participants were 71 fifth-year medical students from two classes at a Chinese medical school and four instructors. The medical students were randomly divided into two groups: the traditional classroom (TC) group (Group A) and the FC group (Group B). Group B used FC for teaching and Group A used PowerPoint-based TC for teaching. The effectiveness of the two teaching models was assessed with Objective Structured Clinical Examination (OSCE), and questionnaires were distributed to the medical students and instructors after the assessment. Two independent sample t-tests were used to analyse the differences in demographic data and OSCE scores of the two groups of medical students.
Results
Group B scored higher in puncture skills than Group A, especially regarding abdominal puncture (p = 0.03), thoracentesis (p < 0.001), bone marrow puncture (p < 0.001), and average performance of puncture skills (p < 0.001). For lumbar puncture, there was no difference in skill scores between Groups A and B (P > 0.409). The medical students thought that the FC improved their self-learning ability and helped them to acquire knowledge. Regarding the OSCE of their skills, most medical students thought that it was more innovative and objective than traditional examinations, and was better for assessing their overall abilities. Both the FC and the OSCE were supported by the medical students. The instructors were also satisfied with the students' performance in the FC and supported the teaching model, agreeing to continue using it.
Conclusions
This study shows that FC teaching that combines instructional videos and group learning is a reliable and well received teaching method for puncture skills, which supplements and expands existing teaching methods in the medical field.
Diagnosis and treatment of syphilitic choroidal retinitis
Authors: Liu Pengfei , Hu Yuzhang
Published: August 2023

Purpose To evaluate the diagnosis and treatment experience of a group of patients with syphilitic choroidal retinitis.
Method Selected 3 patients with syphilitic choroidal retinitis and 2 patients with choroidal retinopathy with similar fundus changes, carefully asking the history, general and specialized examination, such as the best corrected visual acuity (BCVA), slit lamp, binocular indirect ophthalmoscope, fundus photography, autofluorescence (AF), FFA, macular OCT and other auxiliary examinations, and blood routine examiniation, ESR, hypersensitive c-reactive protein, laboratory test of blood transfusion were completed.
Results Correct diagnosis was made and good therapeutic effect was obtained in all the 5 patients ConclusionsThe manifestation of syphilitic choroidal retinitis is complicated. Only by asking the medical history carefully, perfecting the whole body and various specialized examinations and auxiliary examinations, can we make the correct diagnosis and treatment.
FOMO: A Fragment-based Objective Molecule Optimization
Framework
Authors: Ma Cong , Zhang Zeqi , Xu Min , Zhang Haimin
Published: August 2023

Drug discovery greatly relies on optimizing drug-like molecules to improve their properties. In this paper, we propose FOMO, a Fragment-based Objective Molecule Optimization Framework that addresses the challenge of structure collision in molecule optimization. Traditional graph-based methods only considered the types of atoms, bonds, and their connectivity, but they barely account for the varying importance of varying neighboring moieties. FOMO utilizes a multi-head Attention-based Graph model to incorporate the significance of distinct neighboring atoms and bonds during the process of feature aggregation. FOMO is used to modify moieties, by adding new fragments or removing moieties, aiming to improve specific drug-like properties of a given molecule. Our experiments demonstrate that FOMO, trained on a single dataset, generates molecules with superior properties while maintaining similarity to the original molecule. This is important to avoid immediate loss of pharmacological activity of lead compounds. In comparison to the previous state-of-the-art approaches, FOMO achieves the highest success rates in optimizing QED, DRD, PLogP, and multi-objective optimization tasks.
Myeloid dickkopf-1 fuels neurovascular and neuroimmune alterations in ischemic stroke
Authors: ElAli Ayman , Menet Romain , Bernard Maxime , Lecordier Sarah , Trudel Esther , Distéfano-Gagné Félix , Seigneur Josée , Allain Anne-Sophie , Manrique-Castano Daniel , Aldib Natija , Haili Yacine , Bretzner Frederic , Gosselin David
Published: August 2023

Neurovascular impairments and neuroimmune deregulation contribute to injury progression after ischemic stroke. Dickkopf-1 (DKK1) elevated levels correlates with poor stroke outcomes. DKK1 antagonizes the canonical Wnt pathway that plays a critical role in regulating neurovascular and neuroimmune functions. Herein, we report that DKK1 expression in the normal adult brain is absent, but is de novo expressed at the lesion site after experimental ischemic stroke. Using genetic tools to conditionally induce DKK1 expression in a tissue-specific manner, we reveal that its early induction aggravates neurological deficits and injury severity after stroke, associated with altered neuronal and vascular functions. DKK1 post-stroke induction hinders lesion containment by disorganizing the astroglial scar, leading to a chronic neuroinflammation and increased anxiety-like behaviors. Using chimeric mice, we unravel thatDKK1 is released by bone marrow-derived cells (BMDCs) expressing myeloid markers that infiltrate the lesion site. DKK1 restricted induction in BMDCs is sufficient to mediate astroglial scar disorganization. Notably, neutralization of DKK1 limits injury progression and improves neurological recovery after stroke. Our findings indicate that BMDCs-derived DKK1 promotes injury progression after stroke and suggest that neutralizing its biological activity represent a promising therapeutic avenue for ischemic stroke.
Homocysteine Metabolites Inhibit Autophagy by Upregulating the Expression of miR-21-5p (LC3, p62, BECN1), miR-155-5p (ATG5, LC3), miR-216-5p (BECN1, ATG5, LC3) and miR-320c-3p (ATG7) in Human Vascular Endothelial Cells
Authors: Witucki Łukasz , Jakubowski Hieronim
Published: August 2023

Nutritional and genetic deficiencies in homocysteine (Hcy) metabolism lead to hyperhomocysteinemia (HHcy) and cause endothelial dysfunction, a hallmark of atherosclerosis, which is a major cause of cardiovascular disease (CVD). Impaired autophagy causes the accumulation of damaged proteins and organelles and is associated with CVD. Biochemically, HHcy is characterized by elevated levels of Hcy and its metabolites, Hcy-thiolactone and N-Hcy-protein. However, whether these metabolites can dysregulate mTOR signaling and autophagy in endothelial cells is not known. Here, we examined the influence of Hcy-thiolactone, N-Hcy-protein, and Hcy on autophagy human umbilical vein endothelial cells. We found that treatments with Hcy-thiolactone, N-Hcy-protein, or Hcy significantly downregulated BECN1, ATG5, ATG7, and LC3 mRNA and protein levels. We also found that these changes were mediated by upregulation by Hcy-thiolactone, N-Hcy-protein, and Hcy of autophagy-targeting microRNA (miR): miR-21, miR-155, miR-216, and miR-320c. The effects of these metabolites on levels of miR targeting autophagy as well as on the levels of BECN1, ATG5, ATG7, and LC3 mRNA and protein were abrogated by treatments with inhibitors of miR-21, miR-155, miR-216, and mir320c. Taken together, our findings show that Hcy metabolites can upregulate miR-21, miR-155, miR-216, and mir320c, which then downregulate autophagy in human endothelial cells, important for vascular homeostasis.
Symbiodiniaceae Cell Cloning from Corals: High Salinity Activates Endogenous Tolerance against the Bleaching Stress
Authors: Chen Ching-Nen Nathan , Yong Tze Ching , Wang Jih-Terng
Published: August 2023

Coral bleaching is caused by the exocytosis of endosymbiotic dinoflagellates due to overproduction of reactive oxygen species (ROS) in the symbionts when corals are under high temperature and high light stress. Strategies to reduce ROS production and enhance ROS scavenging efficiency in coral symbionts are crucial for preventing the collapse of coral reef ecosystems. However, cell physiology studies of coral symbionts have been hampered by the difficulty of cloning the symbionts. A simple procedure was developed for cloning coral symbionts in this work. Experiments performed with two species of symbionts isolated from Turbinaria sp. revealed that the damages caused by high light at 340 umol photon/m2/s1 was more severe than those caused by high temperature at 36 °C, and high salinity activated endogenous tolerance against the bleaching stress. Pretreatment at 50 ppt salinity reduced the percentage of cells stained for ROS by 59% and 64% in the two species exposed to the bleaching stress compared with those incubated at 30 ppt, and their Fv’/Fm’ recoveries were also improved significantly. These findings suggest that the genomes of coral symbionts have undergone evolutionary processes to develop mechanisms for ameliorating damages caused by high salinity, temperature, and light stress.
The relationship between intrapartum group B streptococcus prophylaxis and allergic rhinitis in children at the age of 3 : a retrospective cohort study of 3010 children
Authors: Zhang Hong , Yin Xiaoping , Shi Yuanmei , Lu Xinhua , Dai Xiaorong , Li Hui , Xu Kang
Published: August 2023

Objective The study was aimed to explore the impact of intrapartum group B streptococcus prophylaxis on allergic rhinitis in children at the age of 3 and provide potential theory evidence to formulate GBS intervention strategies in line with China's national conditions. Methods A population-based retrospective cohort study was used to select 3010 pairs of pregnant women hospitalized in Taixing People's Hospital from June 2018 to December 2019. Hospital information system and face-to-face questionnaires were employed to gather information about allergic rhinitis and related covariates. 1:1 propensity score matching method with a caliper value of 0.02 was used. The comparison of baseline information was conducted using chi-square test for enumeration data, and analysis of variance for measurement data before and after 1:1 propensity score matching, while the modified Poisson regression models were utilized to explore the effect of IAP on AR in children. Results A total of 3010 mother-child pairs were included in the final sample and 381 pairs were obtained in each group with after 1:1 propensity score matching. Among 3010 mother-child pairs, the incidence of allergic rhinitis was higher in the IAP group compared to the non IAP group (9.3% vs 6.1%), with the difference being statistically significant (P = 0.017). After 1:1 propensity score matching, 36 children in the IAP group and 25 children in the non IAP group had AR, and no statistically significant difference was found (9.4% vs 6.6%, P = 0.142). Modified Poisson regression models revealed that children in the IAP group had higher RA risk than children in the non-IAP group (RR: 1.807,95% CI: 1.184–2.757, P = 0.006) before 1:1 propensity score matching. After 1:1 propensity score matching, such significant higher RA risk in children in the IAP group also existed (RR: 1.948,95% CI: 1.158–3.277, P = 0.012). Subgroup analyses revealed that children delivered vaginally (RR: 2.365, 95%CI: 1.327–4.217, P = 0.004), male children (RR: 2.211, 95%CI: 1.036–4.716, P = 0.040) and non-breastfeeding children (RR: 3.585, 95%CI: 1.197–10.742, P = 0.023) in the IAP group had higher RA incidence than that in the non IAP group. Conclusion Intrapartum antibiotic prophylaxis of group B streptococcus increases the cumulative incidence and risk of AR in children at the age of 3 especially children delivered vaginally, male children and non-breastfeeding children, and further studies are urgently required to explore the effect in more specific populations.
What is Human About Writing?: Writing Process Theory and ChatGPT
Authors: Campbell Sarah Hahn
Published: August 2023

Modeling the writing process of brainstorming, outlining, drafting, conferencing, and revising has been accepted as best practice in both K-12 and undergraduate writing instruction for decades. The evolution of technological tools for writing, from typewriters to word processors, from search engines like Google to AI generators like ChatGPT, has complemented and sometimes challenged that pedagogical approach. In this paper, I argue that while the release of ChatGPT to the public in November 2022 has caused anxiety and fear in the education world, it is simply a new technological innovation educators can teach students to utilize as a tool in the writing process. Through discussion of ways in which high school students are currently using ChatGPT to cheat in English class, I argue that fears of cheating actually highlight a larger problem with academic dishonesty, and that writing teachers also see positive possibilities in the innovation. If we can manage the cheating issue, ChatGPT can merely be a new tool for student writers to use as they learn to engage with words as humans: creatively, critically, and contextually.
Piper nigrum extract retards tumor growth by reducing tumor-promoted cytokines/chemokines and modulating immune cells in blood circulation
Authors: Mad-adam Nadeeya , Dokduang Sirinapa , Taraporn Siriporn , Saetang Jirakrit , Nualla-ong Aekkaraj , Rattanaburee Thidarath , Tanawattanasuntorn Tanotnon , Ayudhya Chompunud Chompunud Na , Hiransai Poonsit , Graidist Potchanapond
Published: August 2023

Piper nigrum, black pepper, has been widely used in traditional medicine to treat fevers and digestive system disease and is also applied to treat cancer in China. This study evaluated the breast cancer-preventive effect of a low piperine Piper nigrum extract (PFPE or LP-PE). Our findings showed that the incidence of tumors was 70% in the control group, 50% in the vehicle group, and 20% in the rats treated with PFPE at 50 and 100 mg/kg BW. Remarkably, no cancerous rats were found in the PFPE-treated at 150 mg/kg BW for approximately three months, with no significant changes in blood parameters, except for alkaline phosphatase (ALP). PFPE at 100 and 150 mg/kg BW suppressed cytokines/chemokines and increased ROS production compared to control and vehicle groups. PFPE stimulated IFN- γ promoted Th1 cells and inhibited Th2 and Treg compared to control and vehicle groups. In tumor-bearing rats, PFPE inhibited cancer progression by decreasing ER-α and NF-κB in the tumor tissue compared to control and vehicle groups. Our findings suggested PFPE has the potential to reduce tumor incidence and retardation of tumor growth by modulating Th1/Th2/Treg, ROS, cytokines/chemokines production and decreasing cancer-progression-related proteins in tumor rats.
Saudi Arabia's Post-Oil Economic Prospects: Economic diversification, entrepreneurship and women's empowerment
Authors: Hamdan Allam Mohamed Mousa , awwad bahaa suphi
Published: August 2023

The GCC countries, including Saudi Arabia, have faced significant challenges due to the significant drop in oil prices since 2014, and one important challenge is to limit the financing of their development model based on the exploitation of oil surpluses to achieve comprehensive social and economic development. Another challenge is how to get out of this impasse, and what are the solutions and policies that get the GCC countries out of the curse of natural resources to economic diversification in order to build a more sustainable economy that provides a stable life for the current generation without compromising the capabilities of future generations. This is what this study tried to answer, as it aimed to provide a development model in Saudi Arabia that contributes to getting out of the current oil crisis, and far from researching the causes of the sharp decline in oil prices, which are mostly subject to economic and geopolitical factors that are difficult to control, the current study provides a model that depends on exploiting Saudi Arabia's capabilities through four basic pillars: The trend towards economic diversification, entrepreneurship, and women's economic empowerment are all these changes in light of public sector reform and governance. The proposed study model was theoretically tested through a comprehensive review of the relevant economic and social literature, and then the study applied this model in Saudi Arabia, using a time series that extends since (2001–2020) and constitutes a total of (20) years. Based on econometric methods in collecting and analyzing data and ensuring its validity, and building representative models of the relationship between the study model with its four pillars and economic growth: The study found a number of results indicating a positive impact of economic diversification, entrepreneurship, and public corporate governance on the economic growth of Saudi Arabia, with mixed results on the impact of women's empowerment on economic growth, and based on those results, a set of recommendations were built related to getting out of the oil crisis, encouraging economic diversification and entrepreneurship, and women's economic empowerment.
Voltammetric Determination of Acrylamide Using Coal Tar Pitch Modified Pencil Graphite Electrode by SWV
Authors: Korkmaz Şeyma , Bosnalı Wael , Mülazımoğlu İbrahim Ender , Mülazımoğlu Ayşen Demir
Published: August 2023

The adverse effects of acrylamide (AA) on humans are being clear, especially after a series of related investigations reported the dependance of consuming foods that prepared by exposing to high temperature for a long-time and cancer risk. Accurate determination of AA in food samples at trace amount is considered the first step to overcome this significant problem. The determination of AA using coal tar pitch modified pencil graphite (PGE/CTP) electrode was reported. The electrochemical behavior of AA was studied on PGE/CTP electrode in different medium acidities (pH) of phosphate and Briton-Robinson (BR) buffer solutions by employing square wave voltammetry (SWV). Linear sweep voltammetry (LSV) technique was applied to determine the mass transfer mode of AA from bulk solution to the PGE/CTP electrode surface. The optimum conditions were using phosphate buffer solution (PBS) at pH 7.0. The linear relationship among peak current and AA concentration was in the range 1000.0 nM to 0.5 nM. The limit of detection for detection of AA was 0.2094 nM and the limit of quantitation for quantification was 0.6912 nM. In addition, the PGE/CTP electrode as the sensor was successfully used for the determination of AA in instant coffee sample.
Water-stable boroxine structure with dynamic covalent bonds
Authors: Qing Guangyan , Li Xiaopei , Zhang Yongjie , Shi Zhenqiang , Wang Dongdong , Yang Hang , Zhang Yahui , Qin Haijuan , Lu Wenqi , Chen Junjun , Li Yan
Published: August 2023

Boroxines are significant structures in the synthesis and construction of biological-active compounds, covalent organic frameworks, anion receptors, self-healing materials, and others. However, their utilization in aqueous media is a formidable task due to hydrolytic instability. Here we report a water-stable boroxine structure discovered from 2‑hydroxyphenylboronic acid (HO‑PBA). We find that HO‑PBA exists as a dimer with dynamic covalent bonds (DCBs) and aggregation-induced enhanced emission activity, instead of a monomer. Intriguingly, upon exposure to water, HO‑PBA dimer rapidly transforms into a boroxine structure with excellent pH stability and water-compatible DCBs. Building upon these discoveries, we report the ultra-strong binding capacity of boroxines toward fluoride ions in aqueous media, and develop a boroxine-based hydrogel with high acid–base stability and reversible gel–sol transition. This discovery of the water-stable boroxine structure breaks the constraint of boroxines not being applicable in aqueous environments, opening a new era of researches in boroxine chemistry.
Cateforizing and quantifying doctors' extented responses and communication strategies in medical teleconsultations
Authors: Li Huaikui Kevin
Published: August 2023

This study analyzes 210 clinical teleconsultations using corpus software to categorize and quantify doctors’ extended responses and communication strategies. The results indicate that doctors’ extended responses can be divided into nine categories, with the highest frequency being treatment proposals (including justifications and difficulties in diagnosis) at 42.7%, followed by disease diagnoses (including disease causes and diagnosis difficulties) at 22.0%. The remaining categories have significantly lower frequencies, with the two categories, the introduction of organ or tissue functions and features, and alternative treatment proposals (involving justifications) having the lowest frequency at approximately 2% each. Brown & Levinson’s communication strategy framework is applied to categorize the strategies used in the responses. Four strategies are identified: baldly on-record strategy (BORS), positive politeness strategy (PPS), negative politeness strategy (NPS), and off-record strategy (ORS), each having multiple categories. Specifically, PPS and NPS respectively have five and seven, and BORS and ORS each have three. NPS is the most frequently used, accounting for 89% of all the cases. The category of providing justifications or explanations for a diagnosis has the highest percentage (41.9%), followed by making vague diagnoses and minimizing impositions (22.7% and 16.8% respectively). The remaining categories each have percentages less than 5%. The categories of apologizing and stating a diagnosis as a general clinical practice are the least used (0.9% each). PPS accounts for 9.1% of all the instances, with the category of making a consolation, wish or encouragement, or optimism being the most dominant (5.6%). Each of the remaining categories accounts for no more than 2%. The category of asking for a reason is the least used (0.1%). The overall frequency of BOR and ORS is less than 2%, with each of their categories accounting for less than 1%.
The impact of maternity service restrictions related to Covid-19 on women’s experiences of giving birth in England: A qualitative study
Authors: Irvine Lucy C , Chisnall Georgia
Published: August 2023

Background
The Covid-19 pandemic led to significant changes in maternity service delivery in England, including: antenatal appointments being cancelled or held by phone; women having to attend antenatal scans alone; partners not being allowed to accompany women during labour; visitor restrictions on postnatal wards; and limited postnatal support.
Methods
We conducted semi-structured interviews with 46 women aged 18–45 who had low-risk pregnancies and gave birth to their babies using NHS services in England between 1st March 2020 and 1st March 2021.
Results
Our thematic analysis of interview data generated key themes: profound negative impacts of birth partners not being allowed to accompany women (including on emotional wellbeing, birth preferences and care-seeking choices); deep frustration about policy variation between trusts and inconsistent implementation of guidance; women being more concerned about the risk of giving birth alone than of Covid-19 infection; and women turning towards private care or delaying seeking NHS care so that they could have the birth experience they desired. The latter two results are, to the best of our knowledge, unique to this paper.
Conclusion
Women reported significant negative affects to their emotional and physical wellbeing because of service restrictions. Efforts are required by policymakers and health service providers going forward to re-establish trust in NHS maternity care and ensure capacity to provide for potential shifts in birthplace preferences. Health systems strengthening efforts should prioritise protecting the rights of women to access high quality, person-centred care in the event of future health emergencies that strain NHS capacity.
Optimized Routing Protocol Using Metaheuristic Techniques for Improving Energy Efficiency in WSN
Authors: Shalika Shalika , Meena Uma , Agarwal Ajay
Published: August 2023

A Wireless Sensor Network is a group of small, autonomous sensor nodes which are connected wirelessly and have sensing, processing, and communication capabilities. These nodes are responsible for gathering and monitoring physical information from the surrounding environment. Since these nodes are typically compact and operate with a battery, they have a limited power supply which leads to a constrained network lifetime. Therefore, the use of energy effective techniques that lengthen the network’s lifespan is highly significant. Hence, the objective of this research work is to reduce energy usage and increase the network’s lifespan. Clustering and optimization techniques are commonly used in sensor network to enhance its stability and lifespan. In a clustered sensor network, cluster heads play a crucial role, as they are responsible for performing various tasks that consume more energy. This research work aims to enhance the effectiveness of the network by proposing a hybrid nature-inspired optimization algorithm named as Energy Efficient Yellow Saddle Goatfish Pelican Optimization algorithm (EEYSGPO) which uses Yellow Saddle Goatfish Algorithm to identify the optimum cluster head from a set of nodes. The parameters like residual energy, distance, delay, load, and communication quality are all used to select the optimized cluster head in the clusters. After choosing the optimized cluster head, pelican optimization technique is used to determine the best route for communication between cluster head and the base station, which is calculated on the basis of distance and residual energy. The MATLAB simulator is used for simulation and the obtained results of suggested technique were compared with several existing energy-efficient techniques such as EECHIGWO, SSMOECHS, FGWSTERP and LEACH-PRO using performance measures such as throughput, dead nodes and energy consumption. Simulation findings reveal that the optimal selection of cluster heads and routes in EEYSPO algorithm resolved the issues related to premature convergence and increase the lifetime and scalability of WSN. When compared to the EECHIGWO, SSMOECHS, LEACH-PRO and FGWSTERP protocols, the proposed methodology improves network stability by 57.28 %, 324.5 %, 571.72 % and 91.37 % respectively.
Performance Analysis of Device-to-DeviceCommunication Using Decode-and-Forward-BasedMultiple Relay in the Presence of Co-ChannelInterference
Authors: Tran Huu Q.
Published: August 2023

This paper analyzes the impact of co-channel interference on deviceto-device communication using the energy harvesting (EH) and decode-andforward (DF) technique at multiple relay nodes. The paper presents closedform expressions for the cumulative distribution function (CDF) of the signalto-noise ratio plus co-channel noise (SINR), as well as expressions for the outage probability (OP), throughput, and available rate (AR) of the network. Furthermore, an asymptotic expression is derived to assess the probability densityfunction (PDF) of the instantaneous SINR, offering a simple and generalizedapproach to understanding its characteristics in relation to OP, throughput,and AR. The analysis results are verified through Monte-Carlo simulationsand implemented using Matlab.
Complete genome sequence of a novel mitovirus detected in Colocasia esculenta
Authors: Wu Mengting , Huang Chanchan , Wang Lin , Ke Bin , Lu Yuwen , Peng Jiejun , Rao Shaofei , Wu Guanwei , Chen Jianping , Zheng Hongying , Yan Fei
Published: August 2023

A novel mitovirus was detected in taro (Colocasia esculenta) growing in Ningbo, China. The complete sequence of Colocasia esculenta associated mitovirus 1 (CeaMV1) was determined by next-generation sequencing combined with RT-PCR and RACE. The genome is 2921 nucleotides long and contains a single ORF encoding a putative RNA-dependent RNA polymerase. Homology searches and phylogenetic analysis suggested that CeaMV1 is a member of a new species in the genus Duamitovirus. This is the first report of a member of the family Mitoviridaeassociated with taro.
How self-esteem and resilience mediate the association between screen time and depression symptoms in Chinese adolescents
Authors: Yu Jiahao , Liu Wanqing , She Xinshu , Wang Huan , Wang Min , Abbey Cody , Singh Manpreet K. , Rozelle Scott , Tong Lian
Published: August 2023

Objectives
To clarify the associations between screen time and depression symptoms among Chinese adolescents, as well the mediating roles of self-esteem and resilience.
Methods
A total of 1,624 primary and middle school students aged 9 to 16 years-old from five schools in China were recruited by stratified cluster sampling. The Center for Epidemiologic Studies Depression Scale Revised (CESD-R), Self-Esteem scale (SES), Connor-Davidson Resilience Scale (CD-RISC), and Screen time questionnaire were applied. The data was analyzed by SPSS 26.0 and Amos 26.0.
Results
Screen time was positively associated with depression symptoms (p < 0.001). Self-esteem partially mediated this association (p < 0.05) with a mediation rate of 33.63%, and resilience (p < 0.05) mediated this association with a mediation rate of 6.46%. Self-esteem and resilience formed a mediating chain between screen time and adolescents depression symptoms (p < 0.05) with a mediation rate of 3.15%.
Conclusions
Longer screen time was significantly associated with increased risk of depression symptoms among Chinese adolescents, and self-esteem and resilience partially mediated this association. This evidence provides potential targets for preventive interventions against adolescent depression.
Shake table test of a scaled DiaGrid building model: A Simplistic approach
Authors: Naik Swaral Ravin
Published: August 2023

This study presents a simplistic approach towards shake table experiment on a scaled DiaGrid building model. The DiaGrid mechanism consists of inclined columns in contrast to vertical columns in conventional structural mechanisms. The inclined columns convert all the external actions into axial actions (i.e. axial compression-tension), which makes the mechanism more stiff in resisting lateral forces, mainly high wind gusts and severe earthquake excitations. This study is focused to discuss a simplistic approach for constructing a scaled DiaGrid building model as well for performing a shake table test with few past severe earthquake time histories. The laws of similitudes and the availability of testing resources are the key factors limiting the model's scaling. A Finite element software SAP2000 is used to validate the physical test results. Sticking to the simplistic approach, major parameter targeted for verifying results is ‘lateral displacement’. Displacement values for all the considered earthquakes arrive close to the values obtained in FE analysis. The behavior of an actual DiaGrid structure under future earthquakes can be predicted by performing the simplistic shake table test on a small scale structure subject to probable, non-predictable, or even non-realistic ground shakings that might occur during the life span of the building.
Process Mapping to inform implementation of Trauma-Informed Care for youth aged 14-24 with HIV in the Southern United States
Authors: Brown Leslie Lauren , Wilkins Megan Leigh , Pichon Latrice Crystal , Stewart Jamie Lynn , Sales Jessica McDermott , Audet Carolyn Marie , Hill Samantha Veronica , Pettit April Christine
Published: August 2023

Background: Trauma-Informed Care (TIC) is an evidence-based approach for improving health outcomes by providing systematic, trauma- sensitive and -responsive care. Because TIC adoption varies by setting and population, Implementation Science (IS) is particularly well-suited to guide roll-out efforts. Process Mapping (PM) is an IS model for creating shared visual depictions of systems as they are to identify rate-limiting steps of intervention adoption, but guidance on how to apply PM to guide TIC adoption is lacking. Authors of this study aimed to develop a novel method for conducting TIC-focused PM.
Methods: A real-life TIC implementation study is presented to show how TIC-focused PM was conducted in the case example of a pediatric HIV clinic in a Southern urban area with a high burden of psychological trauma among youth with HIV. A five-phase PM model was applied to evince clinic standards of care, including Preparation, planning and process identification; Data and information gathering; Map generation; Analysis; and Taking it forward. Practices and conditions from four TIC domains were assessed, including Trauma responsive services; Practices of inclusivity, safety, and wellness; Training and sustaining trauma responsiveness; and Cultural responsiveness.
Results: The TIC-focused PM method indicated the case clinic provided limited and non-systematic patient trauma screening, assessment, and interventions; limited efforts to promote professional quality of life and elicit and integrate patient experiences and preferences for care; no ongoing efforts to train and prepare workforce for trauma- sensitive or -responsive care; and no clinic-specific efforts to promote diversity, equity, and inclusion for patients and personnel.
Conclusion: Principles and constructs of resilience-focused TIC were synthesized with a five-phase PM model to generate a baseline depiction of TIC in a pediatric HIV clinic. Results will inform the implementation of TIC in the clinic. Future champions may follow the TIC-focused PM model to guide context-tailored TIC adoption.
Single-cell and spatial transcriptomics uncovers the role of senescent vascular cells in pathological arterial remodeling during atherosclerosis
Authors: Mazan-Mamczarz Krystyna , Tsitsipatis Dimitrios , Carr Angelica , Childs Bennett , Santos Carla Rocha Dos , Anerillas Carlos , Romero Brigette , Gregg Jordan , Michel Marc , Munk Rachel , Martindale Jennifer , Piao Yulan , Fan Jinshui , Hernandez Maria , Kedei Noemi , Wong Madeline , Fedorova Olga , Batish Mona , De Supriyo , Baker Darren , Gorospe Myriam , Herman Allison
Published: August 2023

Studying cardiovascular senescence is crucial for understanding disease-related changes in the cardiovascular system and their impact on health and disease. To systematically investigate the heterogeneity of senescent vascular cells in atherosclerosis, we employed the senescence reporter mouse p16tdTomato+/-, overexpressed PCSK9 and fed a high-fat diet (HFD) to induce atherosclerosis, and treated them with the senolytic drug ABT-737. Whole-aorta, single-cell RNA-sequencing (scRNA-seq) and Gene Set Enrichment Analysis (GSEA) using the SenMayo panel uncovered 10 cell clusters displaying senescent features, although not ‘classical’ senescence markers, that were reduced by treatment with ABT-737. Unbiased subclustering revealed subsets of cells increasing by HFD and reduced by ABT-737 treatment that expressed unique transcripts Spp1, Ctsb, and Tnfrsf11b mRNAs. Spatial analysis of these RNAs identified senescent cells in the cap and core of brachiocephalic arteries from atherosclerotic mice. Our results uncover a vascular-specific transcriptomic signature that may be exploited for therapeutic targeting in age-related vascular diseases.
Investigating the Impacts of Airborne Dust on Herbicide Performance on Redroot Pigweed (Amaranthus retroflexus)
Authors: Kalyani Firouzeh Sharifi , Babaei Sirwan , Zafarsohrabpour Yasin , Nosratti Iraj , Gage Karla , Sadeghpour Amir
Published: August 2023

Dust pollution poses environmental hazards, affecting agriculture through reduced sunlight exposure, photosynthesis, crop yields, and food security. Also, dust adversely impacts plant physiology and herbicide efficacy, but our study found it can also enhance certain herbicides. A factorial experiment was conducted in 2019 and replicated in 2020 to evaluate the interactive effects of dust and various herbicide applications, including bentazon, sulfosulfuron, tribenuron-methyl, aminopyralid + florasulam, foramsulfuron + iodosulfuron + thiencarbazone, 2,4-D + MCPA, and acetochlor on redroot pigweed (Amaranthus retroflexus L.) control efficacy. Dust decreased the total chlorophyll 9.2% content of redroot pigweed by 9.2%, while herbicide application reduced the redroot pigweed’s total chlorophyll by 67.5%. The reduction of total chlorophyll content was more pronounced when herbicides were applied in the presence of dust. Herbicides and dust reduced redroot pigweed's leaf, stem weights, and biomass. Finally, the total biomass of plants was reduced by tribenuron-methyl, aminopyralid + florasulam, sulfosulfuron, and foramsulfuron + iodosulfuron + thiencarbazone regardless of dust presence, showing the most significant effect. The study results indicate that herbicides used in the presence of dust could affect redroot pigweed growth, which signifies the presence of dust, resulting in decreased control efficacy or increased rate of herbicide resistance evolution.
Effectiveness of Yoga Training on the Health-related Physical Fitness and Balance in Children with Autism Spectrum Disorder
Authors: Rostami Samira , Fayazmilani Rana , Yarani Erfan
Published: August 2023

Background: Children diagnosed with Autism Spectrum Disorder (ASD) experience motor difficulties that result in reduced chances for engaging in physical activities and lower levels of fitness. The unique characteristics of yoga can play a substantial role in yielding positive outcomes in terms of physical fitness.
Aim: The present study aims to evaluate the effectiveness of yoga training on the health-related physical fitness and balance of children with ASD.
Methods: Twenty-five children with ASD (mean age 10 ± 0.8 years) were included in the study and randomly assigned to two groups: yoga and control. The yoga sessions were conducted three times per week for eight weeks.
Results: The findings indicated a significant improvement in upper body muscle strength and endurance (P < 0.01), lower body strength and endurance (P < 0.001), core strength and endurance (P < 0.001), flexibility (P < 0.01), static balance (P < 0.001), and dynamic balance (P < 0.05) following yoga training. However, yoga training did not have a significant effect on body fat and cardiorespiratory endurance.
Conclusions: Based on these findings, it is suggested that integrating yoga into the therapeutic approach for children with ASD can improve musculoskeletal fitness and balance, which may have positive effects on their overall physical health and motor development.
A 3D pickup estimation method for industrial parallel robots based on point cloud simplification and registration
Authors: Zhang Yuting , Wang Zongyan , Wang Xi , Gao Pei , Li Menglong
Published: August 2023

In industrial environments, cameras are strongly affected by light and viewpoints, and parallel robots based on traditional vision methods have poor sorting abilities. In two-dimensional vision, depth information cannot be estimated, and parallel robots can only pick up objects based on the fixed height. In this paper, we propose a 3D pickup estimation method for parallel robots based on point cloud simplification and registration for multi-objective pickup tasks. Firstly, a point cloud segmentation method based on the spatial domain is proposed to separate incomplete object point clouds from robot space. The 3D scanner scans the complete object point clouds to produce the object dataset. Secondly, according to the fast point feature histogram (FPFH) and the weight locally optimal projection (WLOP), a fusing the FPFH and WLOP (FF-WLOP) method is proposed to simplify the incomplete point cloud and obtain more distinctive edge features of objects. The complete point cloud in the dataset is aligned with the simplified incomplete point cloud and the coordinate information of the calculated barycenter is given to the incomplete point cloud. Then a dynamic weight singular value decomposition (D-SVD) hand-eye calibration method and a best projection point strategy are proposed to transform the barycenter coordinates of the object to the best pickup coordinates. The experiment results show that the point cloud registration error is 0.38mm, the pickup rate is 92%, and the robot positioning error is 4.67mm, which meets the basic pickup requirements.
Ten cases with ASIA syndrome after BNT162b2 vaccination: Is it a distinct rheumatoid arthritis phenotype?
Authors: Pekdiker Mete , Ketenci Sertaç
Published: August 2023

Purpose
Vaccines are an identified cause of autoimmune/inflammatory syndrome which is termed as autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome). In this research, we aimed to investigate the remarkable features of patients, whom we termed as ASIA syndrome, developing rheumatoid arthritis (RA) after BNT162b2 vaccination
Methods
Patients who were asymptomatic before BNT162b2 vaccination and developed chronic arthritis into three months after vaccination enrolled to the study. Demographic, laboratory, clinical, and treatment characteristics were reviewed retrospectively.
Results
We found 10 patients developing RA following BNT162b2 vaccination. The median age was 54.5 and six was of them were female. The median time between vaccination and onset of symptoms was seven days; seven patients had acute arthritis, and four had intermittent arthritis at the onset of the disease. Only three patients had a disease onset at small joints of the hands. All patients had radiological erosive changes on hand X-rays.
Conclusion
We reported a case series of ASIA syndrome for the first time who developed RA with erosive radiological features after the BNT162b2 vaccine. Acutely onset at atypical joints, intermittent course, and rapidly destructive changes on hand radiographs, were the spectacular features of our cases than classical RA. Vaccine-induced form may be an another subtype of RA but studies with larger sample sizes are needed.
Type III NRG-1 plays a regulatory role in the regeneration process of nerves from the beginning of transplantation
Authors: Wang Jun-Ning , He Sai , Yang Wei-xia , Lu Yao , Li Kun , Zhang Yu-Min , Wang Ya-Kang
Published: August 2023

The present study investigated the effect of type III Neuregulin-1 (NRG-1) on changes in the myelin sheath and the recovery of nerve function during the regeneration process following autologous nerve transplantation. Seventy-two Sprague-Dawley rats were divided into a Blank, Model and (antisense oligonucleotide (ASON) group. The Model and ASON groups of SD rats were subjected to autologous nerve transplantation, and the Blank group only had the sciatic nerve exposed. The Model and ASON groups weregiven local injections of 2 ml PBS buffer solution and 2 ml ASON of Type III NRG-1, respectively, the NRG-1 type III was inhibited by ASON. Changes in the sciatic nerve functional index (SFI) and conduction velocities were observed at different 6 time points. Regeneration of the myelin sheath was observed using transmission electron microscopy. Type III NRG-1 protein was detected using Western blotting and immunohistochemistry, and NRG-1 mRNA was detected using PCR. The SFI of the ASON group was lower than the Model group after transplantation. The conduction velocities of the ASON group on the 14th and 21st days after autologous nerve transplantation were lower than the Model group (P<0.01). The protein and mRNA expression of type III NRG-1 in the ASON group was lower than the Model group at all 6 time points. The area of medullated nerve fibres was significantly different between the ASON group and the Model group on the 3rd day (P<0.05), as was the number of medullated nerve fibres per unit area (P<0.01). The diameter of axons was obviously differentbetween the two groups (P<0.01). Type III NRG-1 played an important regulatory role in the regeneration process of the nerve from the beginning of transplantation to the 28th day.
Assessment of (ORIF PLUS) protocol for management of ankle fractures in diabetic patients
Authors: Abdallah Shreef
Published: August 2023

Back ground; treatment of ankle fractures in diabetic patients is associated with high rate of complications. ORIF plus technique is one of best protocols for management of unstable ankle fractures in diabetic patients, to date no studies to assess this method of management as regard functional outcome and rate of complications.
Methods; prospective study for patients with traumatic acute ankle fractures who will be managed with ORIF plus teqnique patients will be followed for at least six month post-operative for assessment of functional outcome and rate of complications including; infection, nonunion , reoperation ,salvage arthrodesis or amputation .
Results; the obtained results will be collected summarized and statically and analyzed.
Conclusion; this will includes recommendations according to final results.