bluuebunny/crossref_metadata_2025 huggingface dataset:
Elemental mapping in single-particle reconstructions by reconstructed electron energy-loss analysis
Authors: Pfeil-Gardiner Olivia , Rosa Higor Vinícius Dias , Riedel Dietmar , Chen Yu Seby , Lörks Dominique , Kükelhan Pirmin , Linck Martin , Müller Heiko , Van Petegem Filip , Murphy Bonnie J.
Published: October 2024

For macromolecular structures determined by cryogenic electron microscopy, no technique currently exists for mapping elements to defined locations, leading to errors in the assignment of metals and other ions, cofactors, substrates, inhibitors and lipids that play essential roles in activity and regulation. Elemental mapping in the electron microscope is well established for dose-tolerant samples but is challenging for biological samples, especially in a cryo-preserved state. Here we combine electron energy-loss spectroscopy with single-particle image processing to allow elemental mapping in cryo-preserved macromolecular complexes. Proof-of-principle data show that our method, reconstructed electron energy-loss (REEL) analysis, allows a three-dimensional reconstruction of electron energy-loss spectroscopy data, such that a high total electron dose is accumulated across many copies of a complex. Working with two test samples, we demonstrate that we can reliably localize abundant elements. We discuss the current limitations of the method and potential future developments.
A comprehensive Beyond-GDP database to accelerate wellbeing, inclusion, and sustainability research
Authors: Liu Kedi , Wang Ranran , Behrens Paul , Schrijver Inge , Jansen Annegeke , A. Rum Irlan , Hoekstra Rutger
Published: October 2024

“Beyond-GDP” metrics are essential for understanding societal progress. Yet despite their importance, these metrics are scattered across various databases, hindering accessibility and interdisciplinary analysis. Addressing this gap, we present the ‘WISE database’ – the first extensive collection of important Beyond-GDP metrics organized by Wellbeing, Inclusion, and Sustainability (WISE) dimensions. The WISE database consolidates data from a variety of sources, including international institutions and academic publications. It encompasses over one million data points across 244 metrics, covering 218 countries and 61 country groupings, from specific social and environmental indicators to the main Beyond-GDP indexes, and is augmented by essential metadata. The data primarily spans from 1995 to 2015, with some metrics extending back to the 19th century. To improve accessibility and data interpretation, a user-friendly online visualization tool has been developed. The WISE database aims to foster a broader view of societal progress, facilitate research on synergies and trade-offs of wellbeing, inclusion, and sustainability, and provide a foundation for interdisciplinary research.
Association mapping unravels the genetic basis for drought related traits in different developmental stages of barley
Authors: Slawin Connor , Ajayi Oyeyemi , Mahalingam Ramamurthy
Published: October 2024

Drought stress significantly reduces crop yields at all stages of plant development. Barley, known for its abiotic-stress adaptation among cereals was used to examine the genetic basis of drought tolerance. A population of 164 spring barley lines was subjected to polyethylene glycol (PEG) induced drought stress during germination and seedling development. Six traits were measured, including germination percentage and rate, seedling length and weight, and root-to-shoot ratios. Seedling area, volume, and root and shoot diameter was acquired with a flatbed scanner. This population was also subjected to short-term drought during the heading stage in the greenhouse. Root and shoot weight and grain yield data were collected from well watered and droughted plants. Significant variation within traits were observed and several of them exhibited strong correlations with each other. In this population, two genotypes had 100% germination under PEG-induced drought and drought tolerance throughout the heading stage of plant development. A genome-wide association scan (GWAS) revealed 64 significant marker-trait associations across all seven barley chromosomes. Candidate genes related to abiotic stress and germination were identified within a 0.5Mbp interval around these SNPs. In silico analysis indicated a high frequency of differential expression of the candidate genes in response to stress. This study enabled identification of barley lines useful for drought tolerance breeding and pinpointed candidate genes for enhancing drought resiliency in barley.
Carbon stocks in Norwegian eelgrass meadows across environmental gradients
Authors: Gagnon Karine , Thormar Jonas , Fredriksen Stein , Potouroglou Maria , Albretsen Jon , Gundersen Hege , Hancke Kasper , Rinde Eli , Wathne Cecilie , Norderhaug Kjell Magnus
Published: October 2024

Seagrass meadows are well-known for their capacity to capture and store blue carbon in sediments. However carbon stocks vary significantly between meadows, spanning more than three orders of magnitude on both local and global scales. Understanding the drivers of seagrass carbon stocks could help improve strategies for incorporating blue carbon into management plans. Here, we measured sediment carbon stocks in eelgrass (Zostera marina) meadows and unvegetated areas along the Norwegian coast, spanning wide gradients in temperature, wave exposure, water depth, salinity, and eelgrass biomass. Carbon stocks were generally higher in eelgrass meadows than in adjacent unvegetated areas, yet they displayed considerable variation (400 − 30 000 g C m−2 at 50 cm sediment depth) even among nearby sites. Overall, the highest carbon stocks were found in deeper, muddier, sheltered meadows near river mouths. These sites likely have the highest input and retention of carbon from different sources. Consequently, they should be prioritized as conservation targets for preserving coastal blue carbon stocks. Despite ever-increasing efforts to quantify seagrass blue carbon globally, high uncertainties still persist, partly due to differing methodologies, processes, and environmental context. Blue carbon stock estimates could be improved through the coordination of standardised mapping and sampling methods.
Synthesis and characterization of ceramic refractories based on industrial wastes
Authors: Khater G. A. , Romero M. , López-Delgado A. , Padilla I. , El-Kheshen A. A. , Farag M. M. , Elmaghraby M. S. , Nasralla N. H. S.
Published: October 2024

The possibility of reusing ceramic roller waste to produce cordierite and mullite refractories was investigated. Five batches were designed using wastes representing ceramic roller waste, magnesite, and silica sand, shaped and fired at 1300 °C/2 h, and one batch was selected at 1200 °C. The chemical composition and precipitated phases of the used raw materials and the fired batches were analyzed using XRF and XRD techniques, respectively. Densification parameters, morphology, microstructure and electrical properties were also studied to evaluate the effect of the formed phases on the properties of fired materials. Bulk density increases with an increase in mullite and a decrease in cordierite, and it also increases with increasing temperature, whereas porosity and water absorption show a opposite behavior to density (it decreases with an increase in mullite and temperature). The main phases developed after firing at 1300 °C/2 h were cordierite, mullite, corundum, baddeleyite, and spinel. Bending strength increases with increasing mullite percentage and density, and decreasing grain size and porosity. The microstructure develops and becomes finer with increasing mullite percentage and density. The grain size of the crystals was very fine at 1200 °C/2 h and increased at 1300 °C/2 h. Broadband dielectric spectroscopy was employed to study the electrical and dielectric behavior of the investigated samples. The increase in mullite concentration shows a remarkable increase in ε’, especially at lower frequencies, as it is three times higher than that of M10. At f > 103 Hz ε’, frequency independence is accompanied by an increase in mullite concentrations due to the lag of dynamics fluctuations after the alteration of the electric field. The generation of new free ions leads to the enhancement of conductivity as the mullite concentration increases.
Recruitment of autophagy initiator TAX1BP1 advances aggrephagy from cargo collection to sequestration
Authors: Bauer Bernd , Idinger Jonas , Schuschnig Martina , Ferrari Luca , Martens Sascha
Published: October 2024

Autophagy mediates the degradation of harmful material within lysosomes. In aggrephagy, the pathway mediating the degradation of aggregated, ubiquitinated proteins, this cargo material is collected in larger condensates prior to its sequestration by autophagosomes. In this process, the autophagic cargo receptors SQSTM1/p62 and NBR1 drive cargo condensation, while TAX1BP1, which binds to NBR1, recruits the autophagy machinery to facilitate autophagosome biogenesis at the condensates. The mechanistic basis for the TAX1BP1-mediated switch from cargo collection to its sequestration is unclear. Here we show that TAX1BP1 is not a constitutive component of the condensates. Its recruitment correlates with the induction of autophagosome biogenesis. TAX1BP1 is sufficient to recruit the TBK1 kinase via the SINTBAD adapter. We define the NBR1–TAX1BP1-binding site, which is adjacent to the GABARAP/LC3 interaction site, and demonstrate that the recruitment of TAX1BP1 to cargo mimetics can be enhanced by an increased ubiquitin load. Our study suggests that autophagosome biogenesis is initiated once sufficient cargo is collected in the condensates.
Use of UMFNPs/Ce6@MBs in multimodal imaging-guided sono-photodynamic combination therapy for hepatocellular carcinoma
Authors: Xing Lijun , Yang Xiaoting , Bai Jianhua , Zhong Chunting , Cai Jing , Dan Qing , Ji Yiran , Xu Bingxuan , Yu Keyan , Chen Xiaoyu , Qi Yulong , Li Li , Chen Yun , Shuai Xintao , Cheng Guanxun , Liu Li , Zheng Tingting
Published: October 2024

Early diagnosis of liver cancer and appropriate treatment options are critical for obtaining a good prognosis.
Detecting carcinoembryonic antigen based on the aggregation-induced emission enhancement effect
Authors: Lu Yanjun , Wang Mengqi , Yang Yiwen , Tang Qiukai , Zeng Yanbo , Wang Hailong , Zhang Lijie , Pan Chengrui , Hu Changkun , Fu Zhuowei , Li Lei
Published: October 2024

A novel label-free fluorescent aptasensor based on the aggregation-induced emission enhancement effect was developed and applied for the detection of carcinoembryonic antigen.
A GO regulated bimetallic CoFe catalyst for efficient electrochemical nitrate reduction to ammonia under acidic conditions
Authors: Liu Zhengyang , Huang Xiaohan , Yan Linghui , Zhang Zehui , Ding Tao , Shi Guosheng
Published: October 2024

Schematic diagram of the mechanism of electrocatalytic nitrate reduction to ammonia using a CoFe/GO catalyst.
Hierarchical carbon nanofiber-based hybrid film on lightweight magnesium foil for ultrahigh energy density supercapacitors
Authors: Wang Qianyun , Shao Jiao-Jing , Xiong Yuzhu , Wei Tao , Xu Jing
Published: October 2024

Combinatorial battery-like/capacitor energy storage mechanisms as well as an ultralight current collector have been combined to achieve high performance supercapacitors with superior energy density and cyclic life span.
TEMPO-oxidized cellulose nanofiber hydrogel electrolyte for rechargeable Zn-ion batteries
Authors: Kimura Kento , Marangon Vittorio , Fukuda Taiga , Suzuki Mana , Soontornnon Nantapat , Tominaga Yoichi , Hassoun Jusef
Published: October 2024

TEMPO-oxidized cellulose nanofiber gel electrolyte is used in an attractive rechargeable Zn-ion battery delivering at 1.5 V a capacity exceeding 100 mA h g−1, which is proposed for sustainable energy storage.
Zero-dimensional organic–inorganic hybrid indium halide perovskite with broadband yellow light emission
Authors: Wang Qi , Jiang Wei , Xuan Peng-Yao , Zhao Ke , Fu Xiu-Yue , Zhang Xiao-Rui , Lei Xiao-Wu , Yue Cheng-Yang , Kong Xiang-Wen
Published: October 2024

0D indium halide [1-Me-Pipz]2[InCl6]Cl·H2O exhibits strong broadband yellow emission with a high PLQY of 52%. This crystal also demonstrated excellent structural and spectral stability, allowing its use in efficient white light-emitting diodes.
Exploring the host–guest interactions of small molecules in UoC-9(Ca)
Authors: Sebastian Sean S. , Dicke Finn P. , Ruschewitz Uwe
Published: October 2024

In a proof of concept study, the MOF UoC-9(Ca) is investigated as a crystalline sponge material by embedding a variety of small guest molecules in its pores via liquid exchange in single crystal to single crystal transformations using SCXRD analysis.
All-in-one Rh(iii)-covalent organic framework for sustainable and regioselective C(sp2)–H bond functionalization
Authors: Wang Luohe , E Junnan , Bu Xiubin , Zeng Jing , Yang Xiaobo , Fu Hua , Zhao Zhen
Published: October 2024

RhCOF-SYNU-1 serves as a transition-metal catalyst, photocatalyst, and metal ligand, enabling regioselective C(sp2)–H bond functionalization and offering a sustainable approach for Rh(iii) catalysis.
A new S = 1/2 stacked kagomé lattice compound showing two successive ferromagnetic transitions
Authors: Zhu Tianyu , Zhao Zhiying , Cui Meiyan , Zhang Wenhao , He Zhangzhen
Published: October 2024

A new stacked kagomé lattice compound Na6V7(SeO3)8O6F6 was synthesized and it exhibits two successive ferromagnetic transitions at low temperature.
A framework for describing and classifying methane reporting requirements, emission sources, and monitoring methods
Authors: Connor Andy , Shaw Jacob T. , Yarrow Nigel , Howes Neil , Helmore Jon , Finlayson Andrew , Barker Patrick , Robinson Rod
Published: October 2024

A methane framework based on a set of taxonomies and a common lexicon that provides a common structure in which data requirements, emission sources and monitoring methods can be described.
Customized structures of hydrogen-bonded organic frameworks towards photocatalysis
Authors: Ma Chengdi , Qin Liyang , Zhou Tianhua , Zhang Jian
Published: October 2024

This review provides a comprehensive analysis of the unique structural characteristics of HOFs and their diverse functional properties, while further exploring the potential of HOFs in the field of photocatalysis.
Polyethylene microplastics affect behavioural, oxidative stress, and molecular responses in the Drosophila model
Authors: Ranjan Himanshu , Senthil Kumar Swetha , Priscilla Sharine , Swaminathan Subhashini , Umezawa Masakazu , Sheik Mohideen Sahabudeen
Published: October 2024

The study highlights the negative effects of PE MPs on motor functions, oxidative stress, and cellular stress responses in Drosophila, emphasizing the broader ecological risks associated with microplastic pollution.
Equity-centered adaptive sampling in sub-sewershed wastewater surveillance using census data
Authors: Muralidharan Amita , Olson Rachel , Bess C. Winston , Bischel Heather N.
Published: October 2024

Sub-city, or sub-sewershed, wastewater monitoring for infectious diseases offers a data-driven strategy to inform local public health response and complements city-wide data from centralized wastewater treatment plants.
Duckweed: exploring its farm-to-fork potential for food production and biorefineries
Authors: Ujong Anim , Naibaho Joncer , Ghalamara Soudabeh , Tiwari Brijesh K. , Hanon Shay , Tiwari Uma
Published: October 2024

Duckweed is a promising and sustainable aquatic plant offering an eco-friendly alternative for synthesizing high-value bio-products and has potential across food industries, pharmaceuticals, and bioenergy production.
Robust determination of low Ti contents in zircon using LA–ICP–MS/MS with NH3 reaction gas
Authors: Niu Junlong , Wu Shitou , Yang Yueheng , Wang Hao , Huang Chao , Xu Lei , Xie Liewen
Published: October 2024

Compared with the single quadrupole (SQ) mode, Triple Quadrupole (TQ) method is more robust for determining low Ti contents in zircon at high spatial resolutions (laser spot size <20 μm), making it useful for the analysis of complex zircon grains.
A gravity-driven tissue chip to study the efficacy and toxicity of cancer therapeutics
Authors: Rafsanjani Nejad Pouria , Lamichhane Astha , Guragain Prasiddha , Luker Gary , Tavana Hossein
Published: October 2024

A 96-well plate format, fully-automated multi-organ tissue chip array with gravity-driven flow for cancer research.
Synthesis, in silico and bio-evaluation studies of new isothiocyanate derivatives with respect to COX inhibition and H2S release profiles
Authors: Yilmaz Yakup Berkay , Güngör Tuğba , Dönmez Serhat , Atalay Hazal Nazlıcan , Siyah Pınar , Durdağı Serdar , Ay Mehmet , Boyunegmez Tumer Tugba
Published: October 2024

New isothiocyanate derivatives (I1–3 and I1a–e) were synthesized and screened for their anti-inflammatory activities and H2S-releasing capacities. Compounds I1 and I1c demonstrated the most potent and selective COX-2 inhibition.
Stretchable hierarchical metal wire networks for neuromorphic emulation of nociception and anti-nociception
Authors: Yadav Bhupesh , Mondal Indrajit , Kaur Manpreet , N. S. Vidhyadhiraja , Kulkarni Giridhar U.
Published: October 2024

A dual-functional device combines strain-based nociception with neuromorphic memory. Changes in resistance mimic pain responses, while voltage pulses enable memory-like adaptation, offering new possibilities for smart sensory technologies.
Structure and property study for heterobimetallic Au⋯Ag and Au⋯Cu thiolate interlocked [2]catenane and comparison with homometallic Au⋯Au gold(i) thiolate interlocked [2]catenanes – a theoretical study
Authors: Liu Yang , Wu Shui-xing , Pan Qing-qing , Gao Feng-wei , Duan Ying-chen , Kan Yu-he , Su Zhong-min
Published: October 2024

To explore the difference of Au⋯Ag/Cu and Au⋯Au interlocking thiolate [2]catenanes, we carried the comparison of the geometric and electronic structures, ultraviolet-visible spectra and composition of intermolecular interaction forces theoretically.
Selective oxidation of cyclohexane to KA oil over Co and Fe nanoparticles immobilized on layered double hydroxide nanocatalytic system
Authors: Kirar Jagat Singh , Gupta Neeraj Mohan , Chandra Kailash , Vani Hitesh Kumar , Deswal Yogesh , Khare Savita
Published: October 2024

In this study, we prepared Co and Fe nanoparticles supported on a layered double hydroxide abbreviated as CoNPs@LDH and FeNPs@LDH.
Iodination volatilization roasting of ferronickel alloys for selectively volatilizing iron and simultaneously obtaining nickel containing powder
Authors: Qin Hong , Guo Xueyi , Tian Qinghua , Yu Dawei , Li Tianshuang , Zhang Lei
Published: October 2024

Iodination volatilization roasting with I2 was first used to separate Fe and Ni from the ferronickel alloy. Ni was obtained in powder form and Fe was converted to FeI2(g). I2 could be regenerated by oxidizing FeI2.
Pushing a bistable [2]rotaxane out of equilibrium and isolation of the metastable-state co-conformation
Authors: Neumann Mathias S. , Jensen Sofie K. , Frederiksen Rikke , Andersen Sissel S. , Beck Kasper M. , Jeppesen Jan O.
Published: October 2024

A bistable donor–acceptor [2]rotaxane was pushed out of equilibrium by a single redox cycle to produce the high-energy metastable-state co-conformation, which was isolated and it was shown that the energy stored in this co-conformation was 4.4 J L−1.
Zn2+ ions improve the fidelity of metal-mediated primer extension while suppressing intrinsic and Mn2+-induced mutagenic effects by DNA polymerases
Authors: Funai Tatsuya , Tanaka Natsumi , Sugimachi Riyo , Wada Shun-ichi , Urata Hidehito
Published: October 2024

Zn2+ ions effectively suppress the misincorporation of nucleotides during not only usual primer extension reactions but also Ag+- and Hg2+-mediated primer extension reactions.
Boosted aluminum storage performance by d–p orbital modulation in zinc selenide with manganese element dopants
Authors: Wang Han , Kang Rongkai , Zhang Boya , Zhang Xingchang , Chen Guowen , Du Yiqun , Zhang Jianxin
Published: October 2024

By modulating the band center, Mn-ion doping strategy enhances electronic conductivity and improves interaction with solvent groups, thereby achieving high capacity, enhanced kinetics, and long-term cycling in rechargeable aluminum batteries.
Exploring the optimal post-treatment strategy for boosting the electrochemical performances of a new bimetal–organic framework-based supercapacitor
Authors: Dou Xinwen , Liu Mingyue , Cao Tian , Wang Chan , Zhang Yingjie , Jia Yuhang , Ju Qiang , Fang Zhenlan
Published: October 2024

Effects of four kinds of post-treatment strategies on the structures, morphologies, and electrochemical behaviors of MOF derivatives are systematically investigated for the first time.
Synergy of prediction rule and total synthesis in solving the stereochemical puzzle of eucalactam B
Authors: Wang Chenqi , Liu Junyang , Ye Tao
Published: October 2024

The absolute configurations of the fungal-derived reduced polyketide eucalactam B were initially predicted using the “Biochemistry-based rule” and later confirmed through its first successful total synthesis.
Pyrrolylsulfonium salts: stable, accessible and versatile pseudohalides for Stille couplings
Authors: Hann Jodie L. , Lyall Catherine L. , Kociok-Köhn Gabriele , Lewis Simon E.
Published: October 2024

Pyrroles functionalised with a thianthrenium or diphenylsulfonium group undergo Stille couplings with aryl or alkynyl stannanes in good yields, avoiding the issues of instability that can hamper the use of the analogous pyrrolyl halides.
High-performance activated carbon from coconut shells for dye removal: study of isotherm and thermodynamics
Authors: Saleem Junaid , Moghal Zubair Khalid Baig , Pradhan Snigdhendubala , McKay Gordon
Published: October 2024

This study explores producing high-performance activated carbon from coconut shells using acid and base activation, along with biochar functionalization, to efficiently remove dyes from water.
A mini review on aromatization of n-alkanes
Authors: Wang Hongqi , Shiju N. Raveendran
Published: October 2024

The catalytic aromatization of n-alkanes is an important process in the chemical industry, especially for the production of value-added aromatics from the abundant and unreactive small alkanes.
Multi-resonance emitters with room-temperature phosphorescence in amorphous state and excited by visible light
Authors: Du Baoyun , Wu Yuliang , Wang Xingdong , Tian Hongkun , Shao Shiyang , Wang Lixiang
Published: October 2024

Boron, sulfur-based multi-resonance emitter with room-temperature phosphorescence (RTP) is first reported by fusing thiophene into 5,9-dithia-13b-boranaphtho[3,2,1-de]anthracene skeleton, giving efficient RTP in amorphous state under visible light.
Boryl radical-mediated halogen-atom transfer (XAT) enables the Sonogashira-like alkynylation of alkyl halides
Authors: Corpas Javier , Alonso Maialen , Leonori Daniele
Published: October 2024

The Sonogashira-like alkynylation of alkyl halides is achieved by a photocatalytic approach exploiting amine-ligated boryl radicals as halogen-atom transfer mediators in combination with alkynyl sulfones as SOMOphilic reagents.
Pursuing theranostics: a multimodal architecture approach
Authors: Bender Aidan A. , Holiski Connor K. , Embree Mary , Hennkens Heather M. , Klaehn John R. , Lundgreen Ellie , Roberts Andrew G. , Zalupski Peter R. , Mastren Tara
Published: October 2024

Theranostics is a field of nuclear medicine which uses the same targeting vector and chelating system for both a diagnostic and therapeutic radionuclide, allowing for uniformity in imaging and treatment.
Fast Mg-ion insertion kinetics in V2Se9
Authors: Wright Matthew A. , Lim Jungwoo , Pacheco Muino Raul A. , Krowitz Anna E. , Hawkins Cara J. , Bahri Mounib , Daniels Luke M. , Chen Ruiyong , Gomes Chagas Luciana , Cookson James , Collier Paul , Chadwick Alan V. , Browning Nigel D. , Claridge John B. , Hardwick Laurence J. , Rosseinsky Matthew J.
Published: October 2024

V2Se9 demonstrates reversible Mg2+ insertion (up to 1.6/unit) with fast kinetics enabled by low diffusion barriers and structural strain facilitated by low charge density (Se2)2−/Se2− anions, providing insight into future material design.
Superior oxygen evolution reaction activities of highly crystalline Ni1−xFex-LDH (0.20 ≤ x ≤ 0.51) synthesized using soft chemistry
Authors: Ikezawa Atsunori , Koito Shinji , Arai Hajime
Published: October 2024

NiFe-LDHs with high crystallinity and uniform composition and morphology are synthesized using soft chemistry. The highly crystalline NiFe-LDHs show superior OER activities to conventional NiFe-LDHs.
Ultrahigh output energy density of explosive-energy-conversion devices assembled from multilayer ferroelectric films
Authors: Xiong Zhengwei , Zhou Zhangyang , Liu Yi , Fu Zhengqian , Xu Fangfang , Fang Leiming , Liu Xiaoru , Li Jun , Jin Ke , Gao Zhipeng
Published: October 2024

A multilayer PMN–PZT + 2Li film stack with a volume of 0.9 cm3 could generate a current of 3156 A, exceeding that of existing ferroelectric ceramics by 2 orders of magnitude.
Nanobiopolymers in cancer therapeutics: advancing targeted drug delivery through sustainable and controlled release mechanisms
Authors: Gulati Shikha , Ansari Nabeela , Moriya Yamini , Joshi Kumud , Prasad Disha , Sajwan Gargi , Shukla Shefali , Kumar Sanjay , Varma Rajender S.
Published: October 2024

Nanobiopolymers in cancer therapeutics offer sustainable and targeted drug delivery with controlled release, enhancing treatment efficacy while ensuring sustainability and biodegradability for improved patient care.
3D-printed biomimetic scaffolds loaded with ADSCs and BMP-2 for enhanced rotator cuff repair
Authors: Wu Zhonglian , Yang Jian , Chong Hui , Dai Xiaomei , Sun Haidi , Shi Junli , Yuan Meijuan , Liu Dianwei , Dang Mengbo , Yao Hang , Fei Wenyong
Published: October 2024

The schematic diagram of a 3D-printed biomimetic scaffold applied to tendon–bone interface repair.
Skin-inspired laminated liquid metal doped hydrogel with mechanical toughness and high electrical conductivity
Authors: Wang Junlong , Huo Xiaosheng , Huang Wenjun , Xu Junbin , Yu Pengcheng , Zhang Xiangqian , Cong Zhenhua , Niu Jian
Published: October 2024

Skin-inspired laminated hydrogel infused with liquid metal, exhibiting exceptional mechanical toughness and superior electrical conductivity.
The role of prokaryotic argonautes in resistance to type II topoisomerases poison ciprofloxacin
Authors: Galivondzhyan Alina , Sutormin Dmitry , Panteleev Vladimir , Kulbachinskiy Andrey , Severinov Konstantin
Published: October 2024

Argonaute proteins are programmable nucleases found in all domains of life. Eukaryotic argonautes (eAgos) participate in genetic regulation, antiviral response, and transposon silencing during RNA interference. Prokaryotic argonautes (pAgos) are much more diverse than eAgos and have been implicated in defense against invading genetic elements. Recently, it was shown that pAgos protect bacterial cells from a topoisomerase poison ciprofloxacin, raising a possibility that they may play a role in DNA replication and/or repair. Here, we discuss possible models of pAgo-mediated ciprofloxacin resistance. We propose that pAgos could (i) participate in chromosome decatenation as a backup to topoisomerases; (ii) participate in the processing of DNA repair intermediates formed after topoisomerase poisoning, or (iii) induce SOS response that generally affects DNA repair and antibiotic resistance. These hypotheses should guide future investigations of the involvement of pAgos in the emergence of resistance to ciprofloxacin and, possibly, other antibiotics.
The dietary exposome: a brief history of diet, longevity, and age-related health in rodents
Authors: Selman Colin
Published: October 2024

It has been recognized for over a century that feeding animals less food than they would normally eat increases lifespan and leads to broad-spectrum improvements in age-related health. A significant number of studies have subsequently shown that restricting total protein, branched chain amino acids or individual amino acids in the diet, as well as ketogenic diets, can elicit similar effects. In addition, it is becoming clear that fasting protocols, such as time-restricted-feeding or every-other-day feeding, without changes in overall energy intake can also profoundly affect rodent longevity and late-life health. In this review, I will provide a historical perspective on various dietary interventions that modulate ageing in rodents and discuss how this understanding of the dietary exposome may help identify future strategies to maintain late-life health and wellbeing in humans.
Robust planar object tracking using SIFT and GHT with spatial locality
Authors: Lee Suwon , Choi Sang‐Min
Published: October 2024

Planar object tracking (POT) is crucial in vision‐based robotic applications. Despite significant advancements, tracking planar objects under real‐world conditions remains a challenge owing to various factors. The method proposed by the authors leverages SIFT features and generalized Hough transform, which is enhanced by spatial locality, to mitigate background clutter and false matching. The experimental results demonstrate that this method significantly outperforms existing approaches, achieving higher precision across various alignment error thresholds.
A novel online reinforcement learning‐based linear quadratic regulator for three‐level neutral‐point clamped DC/AC inverter
Authors: Qie Tianhao , Zhang Xinan , Xiang Chaoqun , Iu Herbert Ho Ching , Fernando Tyrone
Published: October 2024

This article proposes a novel online reinforcement learning‐based linear quadratic regulator for the three‐level neutral‐point clamped DC/AC voltage source inverter. The proposed controller employs online updated fixed‐weight recurrent neural network (NN) and policy iteration to dynamically adjust the optimal control gains based on real‐time measurements without any knowledge of the system model or offline pre‐training. Moreover, it produces a constant switching frequency with low current harmonics. Compared to the existing control methods, it provides superior control performance, guaranteed control stability, and simplified NN design. Experimental results are presented to verify the effectiveness of the proposed control method.
A novel vehicle power line communication method based on switching ripple modulation
Authors: Zhu He , Xie Zhiyuan , Cao Wangbin , Bai Zonglong , Hu Zhengwei
Published: October 2024

Power converters can perform power conversion and data transmission simultaneously. With the aim of mitigating the hardware requirements of vehicle power line communication (VPLC), a novel VPLC scheme based on switching ripple modulation (SRM) is proposed to eliminate the need for coupling circuits and specialized communication chips. By embedding data modulation techniques into traditional pulse width modulation systems, power/data multiplexing transmission is achieved by demodulating the voltage ripple on the DC bus. First, the theoretical foundation of the SRM is introduced, and power/data single carrier modulation using 2FSK and data demodulation based on the sliding discrete Fourier transform are provided. Subsequently, comprehensive analyses of the mutual influence between power conversion and communication in the buck converter are conducted. The impact of power conversion on communication primarily depends on the control loop compensation and perturbation depth. Moreover, the designs of the ripple conditioning circuit and communication frame are presented. Finally, an experimental prototype is constructed with two buck converters in parallel. The experimental results demonstrate a data transmission rate of 12.5 kbps within 3 m under steady‐state, transient input and output voltage, and transient load conditions, validating the correctness of the proposed methodology.
Long- and short-term variability of the possible nascent planetary nebula IRAS 22568+6141: A late thermal pulse?
Authors: Cala Roldán A. , Miranda Luis F. , Gómez José F. , Morisset Christophe , Soto Federico , Guillén Pedro F. , Vázquez Roberto
Published: October 2024

IRAS 22568+6141 has been classified as a low-excitation planetary nebula (PN) and presents non-thermal radio continuum emission, which could be a signature of a nascent PNe. We present intermediate-resolution long-slit spectra obtained in 2021 and 2023, high-resolution long-slit spectra taken in 2023, and a light curve at the r filter between 1953 and 2019. They all reveal changes in IRAS 22568+6141 with timescales of decades and a few years. The object underwent an energetic event around 1990 that suddenly increased its brightness, which has been fading since then. A comparison with a published spectrum from 1988 shows an increase in the Hβ flux in 2021 by factor of ≃6 and the [O III] emission lines, which were absent in 1988. Between 2021 and 2023, the Hβ flux decreased by a factor of ≃1.7, and the [O III] emission lines almost vanished. These results and the variability observed in other emission lines indicate that IRAS 22568+6141 was recombining and cooling between 2021 and 2023, and probably since 2005, as suggested by archival radio continuum and mid-IR observations. The intermediate- and high-resolution spectra show that the excitation of the emission lines was dominated by shocks in 2021 and 2023, and probably also in 1988, which may be related to the non-thermal radio continuum emission from the object. Although the variability might be due to changes in the physical conditions in the shocks or in a nova-like eruption, it better accommodates that expected from a late thermal pulse, which is further suggested by a comparison with other similar objects. New observations and monitoring in the coming years are crucial to corroborate the origin of the variability.
Big data service investment strategy for low-carbon supply chains with reference effect
Authors: Wang Qinpeng , Wu Guotao , He Longfei
Published: October 2024

By leveraging big data service (BDS), enterprises can gain increasing accurate understanding of the evolving consumer demand for low-carbon products (LCP). This enables them to produce marketable LCP, which is conducive to the achievement of the “net zero” goal. Besides, consumer preference for LCP is influenced by both the product’s emission reduction level (ERL) and the reference emission reduction effect. In this paper, we employ differential games to construct a dual-channel supply chain (DCSC), and explore three scenarios: no investment in BDS, the manufacturer invests in BDS, and jointly investment in BDS. This exploration aims to investigate the reference emission reduction effect and the impact of BDS investment on supply chain emission reduction. Through a comparative analysis of equilibrium results across different scenarios and numerical analysis of key parameters, we find that enterprises should optimize market demand under specific decision-making contexts by managing production costs and selling prices. Low-carbon supply chain (LCSC) enterprises should consider collaborating on BDS investment, sharing consumer low-carbon preference information, and leveraging the value of big data technology to promote emissions reduction production and stimulate low-carbon consumption. This collaboration ultimately aims to expand the market. Additionally, manufacturers and retailers should balance total profits with their individual profits and make concessions in cooperation details. Lastly, it is important that manufacturers should avoid overusing BDS to guide emission reduction production since this may not be beneficial in the long run.
Impacts of e-commerce platform and consumers’ supporting preferences for poor areas in a supply chain
Authors: Sun Wenting , Pang Tao , Peng Hongjun , Feng Xin
Published: October 2024

In this paper, we consider a poverty alleviation (PA) agricultural product supply chain with an e-commerce platform, a farmer in poor areas, and a farmer in other general areas, where the platform with corporate social responsibility and consumers both have supporting preferences for poor areas. We investigate the optimal strategies by further considering logistics cost difference between the poor areas and other areas. The results indicate that the platform and consumers’ supporting preferences are both beneficial to improve the poor farmer’s profit, while they may decrease the sales quantity and the price of general agricultural products. In addition, the high logistics cost of poor areas has negative impacts on the sales of PA agricultural products and the poor farmer’s profit. By virtue of some numerical analysis, we further discover that the platform’s profit improves with its supporting preference only when consumers’ supporting preference is relatively large, or when the platform and consumers’ supporting preferences are both relatively small. In addition, the consumer surplus always improves with supporting preference.
Ressourcenschonend arbeiten in der Anästhesie und im OP
Authors: Schiemann Sarah , Drexler Berthold
Published: October 2024

Tagtäglich sorgen Sie gewissenhaft für die Gesundheit Ihrer Patientinnen und Patienten. Aber haben Sie im Klinikalltag auch ein Auge auf das Wohlergehen der „Patientin Erde“? Im CNE Schwerpunkt stellen wir nachhaltige und ressourcenschonende Praktiken für den Anästhesie- und OP-Bereich vor, die eine gesunde Zukunft für Patienten, medizinisches Personal und die Umwelt fördern.
Der Chirurgie-OP der Uniklinik Heidelberg goes Instagram
Authors: König Karolin , Herlan Nora
Published: October 2024

Instagram, Facebook, TikTok und Co – wer mit dem Puls der Zeit gehen möchte, der kommt an Social Media nicht vorbei. In einer Welt, in der sich vieles um Likes, Klicks und Reichweite dreht, ist Kreativität gefragt, um gesehen zu werden. Der offizielle Instagram-Account „@chirurgie_op_ukhd“ des OPs der Chirurgischen Klinik am Universitätsklinikum Heidelberg nimmt User*innen seit Herbst 2022 mit in den OP-Saal. Amüsante Reels, spannende Beiträge und informative Stories gewähren einen Blick hinter die OP-Abdeckung.
Nicht den Durchblick verlieren – Virtual-Reality-Simulation in der OTA-Ausbildung
Authors: Häfner Luisa , Birkenmeier Marisa , Liel Aaron , Plotzky Christian , Enkler Hans-Georg , Bock Kai-Jonas , Joublin Oriane , Ziegler Sven
Published: October 2024

In einer Zeit, in der Technologie und Ausbildung Hand in Hand gehen, können Operationstechnische Assistentinnen und Assistenten (OTA) in einer virtuellen Realität (VR) trainieren. Hier ist es unproblematischer, Fehler zu machen, als in der echten Welt. Wieso also nicht die spielerischen Aspekte von VR nutzen, um angehende OTA in ihrem eigenen Tempo trainieren zu lassen? Die Zukunft ihrer Ausbildung sieht ein bisschen aus wie ein Videospiel, aber wer hat gesagt, dass Lernen nicht auch Spaß machen kann?
Hypothermie- und Sturzprophylaxe
Authors: Lissner Malte
Published: October 2024

Der Einsatz von Prophylaxen hat sich als wichtiger Teil der pflegerischen Tätigkeit im perioperativen Kontext etabliert. In Ausgabe 4/24 wurden bereits einige anästhesiologische Prophylaxen erläutert, in dieser Ausgabe stellen wir Maßnahmen zur Hypothermie- und Sturzprophylaxe vor.
Berufliche Stressoren und Ressourcen von
Genesungsbegleiter*innen/Peer-Berater*innen in der
Sozialpsychiatrie
Authors: Hoghe Jelena , Röseler Lukas , Limmer Ruth , Walther Christoph , Schütz Astrid
Published: October 2024

Ziel der Studie Erfasst wurden berufliche Stressoren und Ressourcen von
Peer Berater*innen (PB) und als wie belastend bzw. entlastend sie diese
empfinden.

Methode Fragebogengestützte Umfrage

Ergebnisse 175 PB wurden in die Datenanalyse einbezogen und nannten
Stressoren und Ressourcen in ihrem beruflichen Alltag. Psychologische Sicherheit
und Autonomie werden als am häufigsten vorkommende Ressourcen berichtet,
Rollenklarheit am seltensten. Autonomie wird als relativ wenig entlastend
eingestuft, sie kann in Zusammenhang mit Rollenunklarheit auch überfordern. Zwar
fühlen sich PB selten durch das Team stigmatisiert, wenn dies jedoch der Fall
ist, erleben sie die Stigmatisierung als sehr belastend. Relevante Stressoren
waren Unsicherheit in Entscheidungen, Probleme der Teamkultur oder als inadäquat
empfundene Rollenerfüllung durch das Team.

Schlussfolgerungen Obwohl relevante Ressourcen vorhanden sind, ist zu
konstatieren, dass Unklarheiten in den Arbeitsprozessen und den Rollen aller
Beteiligten bedeutsame Belastungen sind.
Wie belastbar ist Deine Diagnose?
Authors: Gruber Achim D. , Wehrend Axel , Steidl Thomas , Kramer Katharina , Merbach Sabine , Baumgärtner Wolfgang , Buyle Thomas , Weisser Niclas-Frederic , Beineke Andreas
Published: October 2024

Die Effektivität und Rechtfertigung jeder Therapie und anderen klinischen
Entscheidung basieren auf einer korrekten Diagnose. Doch viele Arten von
Untersuchungsergebnissen können Unsicherheiten enthalten, die unter Umständen zu
klinischen Fehlentscheidungen führen können. Ähnliches gilt für die
Belastbarkeit von Gutachten für gerichtliche Auseinandersetzungen. Daher ist die
adäquate Mitteilung diagnostischer und gutachterlicher Unsicherheiten im
Untersuchungsbericht bzw. Sachverständigengutachten entscheidend für die
Vermeidung von Fehlentscheidungen. Auch die Haftbarkeit der Person, die die
Leistung erbringt, ist davon betroffen. Unsichere oder gar fehlerhafte Befunde
können jedoch diverse Ursachen haben, von denen nur ein Teil der untersuchenden
oder der beauftragenden Person bekannt sind. Dieser Beitrag bietet eine
Übersicht über 3 verschiedene Arten von Fehleranfälligkeiten am Beispiel
pathologischer Biopsie- und Zytologieuntersuchungen, die so oder ähnlich auch
auf andere tierärztliche Disziplinen übertragbar sind. Ein solides Verständnis
der möglichen Fehlerquellen sowie die adäquate Kommunikation und Diskussion
fallspezifischer, eingeschränkter Wahrscheinlichkeiten in Untersuchungsberichten
und Gutachten tragen wesentlich dazu bei, Fehlentscheidungen zu vermeiden. Bei
den üblicherweise eingesetzten Begriffen wie „mit hoher Wahrscheinlichkeit“,
„Verdacht auf“ oder „nicht auszuschließen“ bestehen jedoch teils unklare bis
abweichende Interpretationen, die hier mit Empfehlungen für einen einheitlichen
Gebrauch erläutert werden. Damit soll die entscheidende Person in die Lage
versetzt werden, im Kontext aller übrigen verfügbaren Daten nötigenfalls weitere
Diagnostik bzw. Beweiserhebung zu veranlassen, um die Irrtumswahrscheinlichkeit
so weit wie möglich zu reduzieren.
Nephrektomie bei einem Kaninchen aufgrund eines renalen
Adenokarzinoms
Authors: Engels Mona , Soutullo Iria Dominguez
Published: October 2024

Der folgende Fallbericht beschreibt den klinischen Ansatz der Diagnostik und
Therapie eines Adenokarzinoms der Niere bei einem 2-jährigen Kaninchen, welches
initial aufgrund von Hyporexie und Polydipsie vorgestellt wurde. In der
klinischen Untersuchung zeigte sich palpatorisch eine abdominale
Umfangsvermehrung, die sich nach weiterführenden Untersuchungen als unilaterale,
für eine Neoplasie verdächtige renale Umfangsvermehrung herausstellte. Nach
einem Tumor-Staging mittels Blutuntersuchung, abdominaler Sonografie und
Röntgenaufnahmen des Thorax und Abdomens, ohne Hinweise auf Metastasen, erfolgte
eine Nephrektomie. Die pathohistologische Untersuchung ergab ein renales
Adenokarzinom. Nach Abheilen der Wunde war der Patient trotz der vorsichtigen
Prognose vollständig symptomfrei und zeigte auch 12 Monate nach der Operation
keine Metastasen oder weitere Einschränkungen.
Forschungsschwerpunkte und Qualität der wissenschaftlichen Literatur
zur Dystokie beim Rind von 1960–2020
Authors: Ulrich Lisa , Wehrend Axel
Published: October 2024

Im Rahmen einer Literaturauswertung wurde mittels einer systematischen Recherche
ermittelt, wie sich in der deutsch- und englischsprachigen Literatur die
Forschungsschwerpunkte über die Schwergeburt beim Rind seit den 1960er Jahren
bis 2020 verändert haben und welche Qualität die bisherige wissenschaftliche
Literatur aufweist. Dazu wurden 621 Literaturstellen ausgewertet. Es zeigt sich,
dass die Anzahl der Veröffentlichungen zwischen 2010 und 2020 deutlich
zugenommen hat, was die anhaltende Aktualität der Thematik unterstreicht.
Fallserien (35,3%) stellen die häufigste Art der Publikation dar. Kontrollierte
Studien (4,5%) und Metaanalysen (0,3%) konnten deutlich seltener gefunden
werden. Die Ursachen (43,8%) und Folgen der Dystokie (28,8%) wurden bisher am
häufigsten untersucht, die Häufigkeit dagegen nur in wenigen Studien (7,2%).
Während Behandlungsmethoden vornehmlich von 1960 bis 1979 analysiert wurden,
lässt sich für die Themenbereiche „Ursachen der Dystokie“ und „Folgen der
Dystokie“ kein zeitlicher Schwerpunkt finden. Veröffentlichungen, die die
Prävention von Dystokie thematisieren, finden sich vermehrt ab den 1980er
Jahren.

Zusammenfassend ist festzuhalten, dass Publikationen zur Ursachen der Dystokie
quantitativ derzeit die höchste Relevanz haben. Für zukünftige
Forschungsprojekte sollten die Studien so geplant werden, dass sie Grundlage für
systematische Studien, Übersichtsarbeiten und Metaanalysen sein können.
StäB vs. Station – Gibt es Unterschiede zwischen den beiden
Behandlungsformen im retrospektiven Verlauf hinsichtlich einzelner objektiver
und subjektiver Outcome-Variablen?
Authors: Raschmann Svenja , Eisele Frank , Flammer Erich , Längle Gerhard
Published: October 2024

Diese retrospektive Verlaufsuntersuchung über ein Jahr (nach Entlassung aus der
Indexbehandlung) vergleicht die Effekte stationsäquivalenter (StäB) und
vollstationärer psychiatrischer Behandlung anhand subjektiver und objektiver
Qualitätsindikatoren. Über ein 1:1 Kohorten-Matching (Diagnose, Alter,
Geschlecht, Zahl der Vorbehandlungen und Krankheitsschwere) konnten 732
StäB-Patient*innen einer Vergleichsgruppe zugeordnet werden. Outcome-Daten
wurden den Routinedaten der Klinikdatenbank und der hausinternen
Basisdokumentation entnommen. Im subjektiven Qualitätsmaß gaben Patient*innen
und Behandelnde in stationärer Behandlung eine signifikant höhere
Zustandsverbesserung an. StäB Patient*innen wiesen deskriptiv häufiger eine
weitere Akutbehandlung auf, hinsichtlich des objektiven Qualitätsmaßes, der Zahl
der weiteren stationären Behandlungstage im Betrachtungszeitraum, unterschieden
sich die beiden Gruppen nicht signifikant, was als Ermutigung für den Einsatz
dieser neuen, sich zunehmend etablierenden Behandlungsform gedeutet werden
kann.
Impact of Surgery Timing and Malperfusion on Acute Type A Aortic Dissection Outcomes
Authors: Zhang Xun E. , Yu Wenda , Yang Hanci , Fu Chao , Wang Bo , Wang Lu , Li Qing-Guo
Published: October 2024

Objective This study aimed to determine the impact of symptom-to-surgery time on mortality in acute type A aortic dissection (ATAAD) patients, with and without malperfusion.

Methods A retrospective analysis of 288 ATAAD patients was conducted. Patients were separated into the early (≤10 h) and late (>10 h) groups by symptom-to-surgery time. Data on characteristics, surgery, and complications were compared, and multivariable logistic regression determined mortality risk factors.

Results Mortality rates did not significantly differ between early and late groups. Age (odds ratio [OR] 1.09, 95% CI 1.05–1.13, p < 0.001), extracorporeal membrane oxygenation use (OR 10.73, 95% CI 2.51–45.87, p = 0.001), and malperfusion (OR 6.83, 95% CI 2.84–16.45, p < 0.001) predicted operative death. Subgroup analysis showed cerebral (OR 3.20, 95% CI 1.11–9.26, p = 0.031), cardiac (OR 5.89, 95% CI 1.32–26.31, p = 0.020), and limb (OR 6.20, 95% CI 1.75–22.05, p = 0.005) malperfusion as predictors of operative death. One (OR 6.30, 95% CI 2.39–16.61, p < 0.001), two (OR 12.79, 95% CI 2.74–59.81, p = 0.001), and three (OR 46.99, 95% CI 7.61–288.94, p < 0.001) organs malperfusion, together with Penn B (OR 7.96, 95% CI 3.04–20.81, p < 0.001) and Penn B-C (OR 12.50, 95% CI 2.65–58.87, p = 0.001) classifications predict operative mortality. Survival analysis revealed significant differences between malperfusion and no malperfusion (34% vs. 9%, p < 0.001) but not between late and early (14% vs. 21%, p = 0.132) groups. Malperfusion remained an essential predictor of operative (OR 7.06 95% CI 3.11–17.19, p < 0.001) and midterm mortality (OR 3.38 95% CI 1.97–5.77, p < 0.001) in subgroup analysis.

Conclusion Preoperative malperfusion status, rather than symptom-to-surgery time, significantly impacts both operative and midterm mortality in ATAAD patients.