bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Method for Decision Making by Double-Quantitative Rough Sets in Hesitant Fuzzy Systems
Authors: Zhang Xiaoyan , Yang Qian
Published: June 2022

In some complex decision-making issues such as economy, management, and social development, decision makers are often hesitant to reach a consensus on the decision-making results due to different goals. How to reduce the influence of decision makers’ subjective arbitrariness on decision results is an inevitable task in decision analysis. Following the principle of improving the fault-tolerance capability, this paper firstly proposes the graded and the variable precision rough set approaches from a single-quantitative decision-making view in a hesitant fuzzy environment (HFEn). Moreover, in order to improve the excessive overlap caused by the high concentration of single quantization, we propose two kinds of double-quantitative decision-making methods by cross-considering relative quantitative information and absolute quantitative information. The proposal of this method not only solves the fuzzy system problem of people’s hesitation in the decision-making process, but also greatly enhances the fault-tolerant ability of the model in application. Finally, we further compare the approximation process and decision results of the single-quantitative models and the double-quantitative models, and explore some basic properties and corresponding decision rules of these models. Meanwhile, we introduce a practical example of housing purchase to expound and verify these theories, which shows that the application value of these theories is impressive.
Hilfer Fractional Neutral Stochastic Volterra Integro-Differential Inclusions via Almost Sectorial Operators
Authors: Sivasankar Sivajiganesan , Udhayakumar Ramalingam
Published: June 2022

In our paper, we mainly concentrate on the existence of Hilfer fractional neutral stochastic Volterra integro-differential inclusions with almost sectorial operators. The facts related to fractional calculus, stochastic analysis theory, and the fixed point theorem for multivalued maps are used to prove the result. In addition, an illustration of the principle is provided.
Potential Role of Certain Biomarkers Such as Vitamin B12, ROS, Albumin, as Early Predictors for Prognosis of COVID-19 Outcomes
Authors: Lymperaki Evgenia , Kazeli Konstantina , Variti Georgia , Gerothanasi Magda , Gkinoudis Argyrios , Tsamesidis Ioannis , Vagdatli Eleni
Published: June 2022

COVID-19 disease is still a major global concern because of its morbidity and its mortality in severe disease. Certain biomarkers including Reactive Oxygen Species (ROS), vitamins, and trace elements are known to play a crucial role in the pathophysiology of the disease. The aim of our study was to evaluate how certain biomarkers, such as ROS, biochemical indicators, trace elements in serum blood of 139 COVID-19 hospitalized patients, and 60 non-COVID cases according to age and sex variations, can serve as the predictors for prognosis of COVID-19 outcome. An attempt of correlating these biomarkers with the severity of the disease as well as with each other is represented. All subjects were hospitalized from April 2021 until June 2021. A statistically significant increase of B12 levels (p = 0.0029) and ROS levels (p < 0.0001) as well as a decrease in albumin and Total Protein (T.P.) levels (p < 0.001) was observed especially in the early stage of the disease before CRP and ferritin elevation. Additionally, a statistically significant increase in ferritin (p = 0.007), B12 (p = 0.035, sALT p = 0.069, Glucose p = 0.012 and urea p = 0.096 and a decrease in Ca p = 0.005, T.P p = 0.052 albumin p = 0.046 between stage B (CRP values 6–30 mg/L) and C (CRP values 30–100 mg/L) was evident. Thus, this study concludes that clinicians could successfully employ biomarkers such as vitamin B12, ROS and albumin as possible prognosis tools for an early diagnosis. In addition, the total biochemical profile can assist in the understanding of the severity of COVID-19 disease, and could potentially lead to a better diet or early pharmaceutical treatment to prevent some of the more acute symptoms.
Novel Membranes for Environmental Application
Authors: Zou Dong , Zhong Zhaoxiang
Published: June 2022

Membrane-based separations for water purification and gas separation have been applied extensively to address the global challenges of water scarcity and the pollution of aquatic and air environments [...]
Design and Experimental Research of 3-RRS Parallel Ankle Rehabilitation Robot
Authors: Zou Yupeng , Zhang Andong , Zhang Qiang , Zhang Baolong , Wu Xiangshu , Qin Tao
Published: June 2022

The ankle is a crucial joint that supports the human body weight. An ankle sprain will adversely affect the patient’s daily life, so it is of great significance to ensure its strength. To help patients with ankle dysfunction to carry out effective rehabilitation training, the bone structure and motion mechanism of the ankle were analyzed in this paper. Referring to the configuration of the lower-mobility parallel mechanism, a 3-RRS (R and S denote revolute and spherical joint respectively) parallel ankle rehabilitation robot (PARR) was proposed. The robot can realize both single and compound ankle rehabilitation training. The structure of the robot was introduced, and the kinematics model was established. The freedom of movement of the robot was analyzed using the screw theory, and the robot kinematics were analyzed using spherical analytics theory. A circular composite rehabilitation trajectory was planned, and the accuracy of the kinematics model was verified by virtual prototype simulation. The Multibody simulation results show that the trajectory of the target point is basically the same as the expected trajectory. The maximum trajectory error is about 2.5 mm in the simulation process, which is within the controllable range. The experimental results of the virtual prototype simulation show that the maximum angular deflection error of the three motors is 2° when running a circular trajectory, which meets the experimental requirements. Finally, a control strategy for passive rehabilitation training was designed, and the effectiveness of this control strategy was verified by a prototype experiment.
Alternate Special Stains for the Detection of Mycotic Organisms in Oral Cyto-Smears—A Histomorphometric Study
Authors: Sowmya S. V. , Augustine Dominic , Hemanth Beena , Prathab Arcot Gopal , Alamoudi Ahmed , Bahammam Hammam Ahmed , Bahammam Sarah Ahmed , Bahammam Maha A. , Haragannavar Vanishri C. , Prabhu Sonia , Patil Shankargouda
Published: June 2022

In the wake of the COVID-19 pandemic, fungal infections of the maxillofacial region have become prevalent, making their accurate diagnosis vital. Histopathological staining remains a simple, cost-effective technique for differentiation and diagnosis of the causative fungal organisms. The present study aims to evaluate the staining efficacy of Periodic Acid-Schiff (PAS), Alcian Blue, Safranin-O and Gomori’s Methenamine Silver (GMS) on fungal smears. This research work also attempts to study the morphometric characteristics of Candida albicans, Aspergillus flavus, Rhizopus oryzae. Candida albicans, Aspergillus flavus and Rhizopus oryzae, 10 smears each, were stained using PAS, Alcian Blue, Safranin-O and GMS. The morphological characteristics and staining efficacy were examined, and semi-quantitative scoring was performed. Candida albicans, Aspergillus flavus and Rhizopus oryzae were stained for the first time with Safranin-O. The morphometric traits were then analyzed using an image analysis software. Safranin-O provided the most reliable staining efficacy amongst the stains and optimum morphological definition for all three organisms. Safranin-O was found to be superior to PAS and GMS, ensuring detection of even the most minute mycotic colonies. The hyphae of Aspergillus flavus to be the largest, and the spores and fruiting body of Rhizopus oryzae were found to be the largest amongst the three organisms compared. Early and accurate diagnosis of fungal infections can significantly reduce morbidity in orofacial fungal infections.
Effects of Fermented Herbal Tea Residue on Serum Indices and Fecal Microorganisms of Chuanzhong Black Goats
Authors: Gao Chongya , Wu Longfei , Zhao Weiran , Chen Yiye , Deng Ming , Liu Guangbin , Guo Yongqing , Sun Baoli
Published: June 2022

Herbal tea residues (HTRs) are a by−product of herbal tea processing that contains many nutrients and active substances but are often discarded as waste. The main aim of the present study was to determine the food safety of HTRs and lay the foundation for its use as a novel feed resource for goats. In this study, discarded HTRs were fermented and then fed to 33 female Chuanzhong black goats (121 ± 4.00 days) with similar weight (9.33 ± 0.95 kg) and genetic background, which were divided into three groups (fermented herbal tea residue (FHTR) replacement of 0%, 15% and 30% of the forage component of the diet). The feeding experiment lasted for 35 days. On day 35, our findings indicated that the concentrations of hydroxyl radicals and urea increased linearly, and the concentrations of glutathione peroxidase increased quadratically with the increase in FHTR. In addition, we investigated the fecal microbiota composition of eight Chuanzhong black goats in the control, 15% and 30% FHTR replacement groups and found that FHTR had no remarkable effect on the fecal microbiota composition. Results indicated that goat physiological functions remained stable after FHTR was added to the diet.
Tin and Bronze Production at the Outeiro de Baltar Hillfort (NW Iberia)
Authors: Figueiredo Elin , Rodrigues Alexandra , Fonte João , Meunier Emmanuelle , Dias Filipa , Lima Alexandre , Gonçalves José Alberto , Gonçalves-Seco Luís , Gonçalves Filipe , Pereira Manuel F. C. , Silva Rui J. C. , Veiga João P.
Published: June 2022

Findings of Iron Age metallurgical activities related to tin metal and mining are very rare. In the present work, we present a detailed study of the Outeiro de Baltar hillfort, dated to the Late Iron Age/Early Roman period, located in a place where 20th century tin mining work took place. Elemental and microstructural analysis by portable, micro and wavelength dispersive X-ray fluorescence spectrometry (pXRF, micro-XRF and WDXRF) and scanning electron microscopy with energy dispersion spectrometer (SEM-EDS) showed that metallurgical debris found at the archaeological site is related to tin smelting and binary and ternary bronze productions. Analysis of the artefacts of diverse typologies found at the site showed that a variety of metals and alloys were in circulation and use. Samples of tin ores (cassiterite) from the region were analyzed for comparison with an archaeological tin slag from the site. The analytical results point to the production of tin metal using local cassiterite and the production of bronze by directly adding cassiterite into a smelting process. Furthermore, data of remote sensing (airborne Light Detection and Ranging (LiDAR) and historical aerial imagery) and Geographical Information System (GIS) mapping were combined with archival mining documentation and maps to retrieve a landscape context for the site. The study showed that the place of the Outeiro de Baltar hillfort (NW Iberia) was mined periodically over time.
How to Catch the Ball: Fullerene Binding to the Corannulene Pincer
Authors: Menezes Filipe , Popowicz Grzegorz Maria
Published: June 2022

The corannulene pincer (also known in the literature as the buckycatcher) is a fascinating system that may encapsulate, among other molecules, the C60 and C70 fullerenes. These complexes are held together by strong π-stacking interactions. Although these are quantum mechanical effects, their description by quantum chemical methods has proved very hard. We used three semi-empirical methods, PM6-D3H4X, PM6-D3H+ and GFN2-xTB, to model the interactions. Binding to fullerenes was extended to all open conformations of the buckycatcher, and with the proper choice of solvation model and partition functions, we obtained Gibbs free energies of binding that deviated by 1.0–1.5 kcal/mol from the experimental data. Adding three-body dispersion to PM6-D3H+ led to even better agreement. These results agree better with the experimental data than calculations using higher-level methods at a significantly lower fraction of the computational cost. Furthermore, the formation of adducts with C60 was studied using dynamical simulations, which helped to build a more complete picture of the behavior of the corannulene pincer with fullerenes. We also investigated the use of exchange-binding models to recover more information on this system in solution. Though the final Gibbs free energies in solution were worsened, gas-phase enthalpies and entropies better mirrored the experimental data.
New Alk(en)ylhydroxycyclohexanes with Tyrosinase Inhibition Potential from Harpephyllum caffrum Bernh. Gum Exudate
Authors: Bodede Olusola , More Garland K. , Moodley Roshila , Steenkamp Paul , Baijnath Himansu , Maharaj Vinesh , Prinsloo Gerhard
Published: June 2022

This work presents the first report on the phytochemical investigation of Harpephyllum caffrum Bernh. gum exudate. A known cardanol, 3-heptadec-12′-Z-enyl phenol (1) and three new alk(en)ylhydroxycyclohexanes, namely, (1R,3R)-1,3-dihydroxy-3-[heptadec-12′(Z)-enyl]cyclohexane (2) (1S,2S,3S,4S,5R)-1,2,3,4,5-pentahydroxy-5-[octadec-13′(Z)-enyl]cyclohexane (3) and (1R,2S,4R)-1,2,4-trihydroxy-4-[heptadec-12′(Z)-enyl]cyclohexane (4) were isolated from the gum. The structures of the compounds were determined by extensive 1D and 2D NMR spectroscopy and HR-ESI-MS data. The ethanolic extract of the gum was found to be the most potent tyrosinase inhibitor with IC50 of 11.32 µg/mL while compounds 2 and 3, with IC50 values of 24.90 and 26.99 µg/mL, respectively, were found to be potential anti-tyrosinase candidates from the gum. Gum exudate may be a potential source for non-destructive harvesting of selective pharmacologically active compounds from plants. The results also provide evidence that H. caffrum gum may find application in cosmetics as a potential anti-tyrosinase agent.
Carbon Quantum Dots Based Chemosensor Array for Monitoring Multiple Metal Ions
Authors: Qin Tianlei , Wang Jiayi , Liu Yuanli , Guo Song
Published: June 2022

The simultaneous identification of multiple metal ions in water has attracted enormous research interest in the past few decades. We herein describe a novel method for multiple metal ion detection using a carbon quantum dots (CQDs)-based chemosensor array and the CQDs are functionalized with different amino acids (glutamine, histidine, arginine, lysine and proline), which act as sensing elements in the sensor array. Eleven metal ions are successfully identified by the designed chemosensor array, with 100% classification accuracy. Importantly, the proposed method allowed the quantitative prediction of the concentration of individual metal ions in the mixture with the aid of a support vector machine (SVM). The sensor array also enables the qualitative detection of unknown metal ions under the interference of tap water and local river water. Thus, the strategy provides a novel high-throughput approach for the identification of various analytes in complex systems.
Structural Dynamics of the SARS-CoV-2 Spike Protein: A 2-Year Retrospective Analysis of SARS-CoV-2 Variants (from Alpha to Omicron) Reveals an Early Divergence between Conserved and Variable Epitopes
Authors: Guérin Patrick , Yahi Nouara , Azzaz Fodil , Chahinian Henri , Sabatier Jean-Marc , Fantini Jacques
Published: June 2022

We analyzed the epitope evolution of the spike protein in 1,860,489 SARS-CoV-2 genomes. The structural dynamics of these epitopes was determined by molecular modeling approaches. The D614G mutation, selected in the first months of the pandemic, is still present in currently circulating SARS-CoV-2 strains. This mutation facilitates the conformational change leading to the demasking of the ACE2 binding domain. D614G also abrogated the binding of facilitating antibodies to a linear epitope common to SARS-CoV-1 and SARS-CoV-2. The main neutralizing epitope of the N-terminal domain (NTD) of the spike protein showed extensive structural variability in SARS-CoV-2 variants, especially Delta and Omicron. This epitope is located on the flat surface of the NTD, a large electropositive area which binds to electronegatively charged lipid rafts of host cells. A facilitating epitope located on the lower part of the NTD appeared to be highly conserved among most SARS-CoV-2 variants, which may represent a risk of antibody-dependent enhancement (ADE). Overall, this retrospective analysis revealed an early divergence between conserved (facilitating) and variable (neutralizing) epitopes of the spike protein. These data aid in the designing of new antiviral strategies that could help to control COVID-19 infection by mimicking neutralizing antibodies or by blocking facilitating antibodies.
Discovery of Quinazoline-2,4(1H,3H)-Dione Derivatives as Potential Antibacterial Agent: Design, Synthesis, and Their Antibacterial Activity
Authors: Boshta Nader M. , El-Essawy Farag A. , Alshammari Mohammed B. , Noreldein Safaa G. , Darwesh Osama M.
Published: June 2022

In this paper, we report on the design and synthesis of a novel series of quinazoline-2,4(1H,3H)-dione derivatives as fluoroquinolone-like inhibitors of bacterial gyrase and DNA topoisomerase IV to identify and develop antimicrobial agents to prevent bacterial resistance problems. Their structures were confirmed using spectroscopic analyses (IR, NMR, and EI-MS). The novel quinazoline-2,4(1H,3H)-dione derivatives were evaluated for their antimicrobial activities against Gram-positive and Gram-negative bacterial strains using the Agar well diffusion method to study the antimicrobial activities and compared them with the standard drugs. Most compounds displayed moderate activity. Among the tested compounds, the most promising compounds 13 and 15 provided broad bioactive spectrum against Gram-positive and Gram-negative strains compared to the standard drugs.
Imidazo[1,5-a]pyridine-Based Fluorescent Probes: A Photophysical Investigation in Liposome Models
Authors: Renno Giacomo , Cardano Francesca , Volpi Giorgio , Barolo Claudia , Viscardi Guido , Fin Andrea
Published: June 2022

Imidazo[1,5-a]pyridine is a stable scaffold, widely used for the development of emissive compounds in many application fields (e.g., optoelectronics, coordination chemistry, sensors, chemical biology). Their compact shape along with remarkable photophysical properties make them suitable candidates as cell membrane probes. The study of the membrane dynamics, hydration, and fluidity is of importance to monitor the cellular health and to explore crucial biochemical pathways. In this context, five imidazo[1,5-a]pyridine-based fluorophores were synthesized according to a one-pot cyclization between an aromatic ketone and benzaldehyde in the presence of ammonium acetate and acetic acid. The photophysical features of prepared compounds were investigated in several organic solvents and probes 2–4 exhibited the greatest solvatochromic behavior, resulting in a higher suitability as membrane probes. Their interaction with liposomes as artificial membrane model was tested showing a successful intercalation of the probes in the lipid bilayer. Kinetic experiments were carried out and the lipidic phase influence on the photophysical features was evaluated through temperature-dependent experiments. The results herein reported encourage further investigations on the use of imidazo[1,5-a]pyridine scaffold as fluorescent membrane probes.
Dietary Nitrate Intake Is Associated with Decreased Incidence of Open-Angle Glaucoma: The Rotterdam Study
Authors: Vergroesen Joëlle E. , de Crom Tosca O. E. , Blekkenhorst Lauren C. , Klaver Caroline C. W. , Voortman Trudy , Ramdas Wishal D.
Published: June 2022

Previous studies suggest that nitric oxide is involved in the regulation of the intraocular pressure (IOP) and in the pathophysiology of open-angle glaucoma (OAG). However, prospective studies investigating the association between dietary nitrate intake, a source of nitric oxide, and incident (i)OAG risk are limited. We aimed to determine the association between dietary nitrate intake and iOAG, and to evaluate the association between dietary nitrate intake and IOP. From 1991 onwards, participants were followed each five years for iOAG in the Rotterdam Study. A total of 173 participants developed iOAG during follow-up. Cases and controls were matched on age (mean ± standard deviation: 65.7 ± 6.9) and sex (%female: 53.2) in a case:control ratio of 1:5. After adjustment for potential confounders, total dietary nitrate intake was associated with a lower iOAG risk (odds ratio (OR) with corresponding 95% confidence interval (95% CI): 0.95 (0.91–0.98) for each 10 mg/day higher intake). Both nitrate intake from vegetables (OR (95% CI): 0.95 (0.91–0.98) for each 10 mg/day higher intake) and nitrate intake from non-vegetable food sources (OR (95% CI): 0.63 (0.41–0.96) for each 10 mg/day higher intake) were associated with a lower iOAG risk. Dietary nitrate intake was not associated with IOP. In conclusion, dietary nitrate intake was associated with a reduced risk of iOAG. IOP-independent mechanisms may underlie the association with OAG.
Exploring the Involvement of the Amyloid Precursor Protein A673T Mutation against Amyloid Pathology and Alzheimer’s Disease in Relation to Therapeutic Editing Tools
Authors: Stanciu Gabriela Dumitrita , Ababei Daniela Carmen , Rusu Razvan Nicolae , Bild Veronica , Tamba Bogdan-Ionel
Published: June 2022

Alzheimer’s disease (AD) is biologically defined as a complex neurodegenerative condition with a multilayered nature that leads to a progressive decline in cognitive function and irreversible neuronal loss. It is one of the primary diseases among elderly individuals. With an increasing incidence and a high failure rate for pharmaceutical options that are merely symptom-targeting and supportive with many side effects, there is an urgent need for alternative strategies. Despite extensive knowledge on the molecular basis of AD, progress concerning effective disease-modifying therapies has proven to be a challenge. The ability of the CRISPR–Cas9 gene editing system to help identify target molecules or to generate new preclinical disease models could shed light on the pathogenesis of AD and provide promising therapeutic possibilities. Here, we sought to highlight the current understanding of the involvement of the A673T mutation in amyloid pathology, focusing on its roles in protective mechanisms against AD, in relation to the recent status of available therapeutic editing tools.
The Potential of Cell-Penetrating Peptides for mRNA Delivery to Cancer Cells
Authors: Kim Yelee , Kim Hyosuk , Kim Eun Hye , Jang Hochung , Jang Yeongji , Chi Sung-Gil , Yang Yoosoo , Kim Sun Hwa
Published: June 2022

In vitro transcribed mRNA for the synthesis of any given protein has shown great potential in cancer gene therapy, especially in cancer vaccines for immunotherapy. To overcome physiological barriers, such as rapid degradation by enzymatic attack and poor cellular uptake due to their large size and hydrophilic properties, many delivery carriers for mRNAs are being investigated for improving the bioavailability of mRNA. Recently, cell-penetrating peptides (CPPs) have received attention as promising tools for gene delivery. In terms of their biocompatibility and the ability to target specific cells with the versatility of peptide sequences, they may provide clues to address the challenges of conventional delivery systems for cancer mRNA delivery. In this study, optimal conditions for the CPP/mRNA complexes were identified in terms of complexation capacity and N/P ratio, and protection against RNase was confirmed. When cancer cells were treated at a concentration of 6.8 nM, which could deliver the highest amount of mRNA without toxicity, the amphipathic CPP/mRNA complexes with a size less than 200 nm showed high cellular uptake and protein expression. With advances in our understanding of CPPs, CPPs designed to target tumor tissues will be promising for use in developing a new class of mRNA delivery vehicles in cancer therapy.
Exploring the Diverse Morphology of Porous Poly(Lactic Acid) Fibers for Developing Long-Term Controlled Antibiotic Delivery Systems
Authors: Seo Kwon Ho , Lee Kyung Eun , Yanilmaz Meltem , Kim Juran
Published: June 2022

In this study, we aimed to explore the morphologies of porous poly(lactic acid) (PLA) fibers through liquid–liquid phase separation, and investigate the relationship among pore formation, physical properties, and antibacterial activities of the fibers for identifying their potential as drug delivery carriers. Antibacterial activities of gentamicin-, kanamycin-, and amikacin-loaded PLA fibers against E. coli and S. epidermidis were evaluated. The antibacterial activity of drugs against E. coli showed the following profile: gentamicin > amikacin > kanamycin; however, S. epidermidis growth was almost completely inhibited immediately after the administration of all three drugs. The efficiency of gentamicin can be attributed to the electrostatic interactions between the positively and negatively charged antibiotic and bacterial cell membrane, respectively. Furthermore, gentamicin-loaded porous PLA fibers were evaluated as drug delivery systems. The cumulative amount of gentamicin in porous PLA nanofibers was considerably higher than that in other PLA fibers for 168 h, followed by 7:3 PLA > 6:4 PLA > 5:5 PLA > non-porous PLA. The 7:3 PLA fibers were projected to be ideal drug carrier candidates for controlled antibiotic release in delivery systems owing to their interconnected internal structure and the largest surface area (55.61 m2 g−1), pore size (42.19 nm), and pore volume (12.78 cm3 g−1).
Application of Fiber Biochar–MOF Matrix Composites in Electrochemical Energy Storage
Authors: Gao Meixiang , Lu Meng , Zhang Xia , Luo Zhenhui , Xiao Jiaqi
Published: June 2022

Fiber biochar–metal organic framework (MOF) composites were successfully prepared by three different biochar preparation methods, namely, the ionic liquid method, the pyrolysis method, and the direct composite method. The effects of the different preparation methods of fiber biochar on the physical and chemical properties of the biochar–MOF composites showed that the composite prepared by the ionic liquid method with the Zeolite-type imidazolate skeleton -67 (ZIF-67) composite after high temperature treatment exhibited a better microstructure. Electrochemical tests showed that it had good specific capacity, a fast charge diffusion rate, and a relatively good electrochemical performance. The maximum specific capacity of the composite was 63.54 F/g when the current density was 0.01 A/g in 1 mol/L KCl solution. This work explored the preparation methods of fiber biochar–MOF composites and their application in the electrochemical field and detailed the relationship between the preparation methods of the composites and the electrochemical properties of the electrode materials.
A Facile Fabrication of Lysosome-Targeting pH Fluorescent Nanosensor Based on PEGylated Polyester Block Copolymer
Authors: Wang Lijun , Zhou Qiang , Yang Haiyang
Published: June 2022

A novel lysosome-targeting PEGylated polyester-based fluorescent pH nanosensor is fabricated by the combination of ring-opening copolymerization (ROCOP), side-group modification and subsequent self-assembly. First, a key target amphiphilic copolymer carrier for rhodamine (Rh) pH indicator is synthesized in a facile manner by the ROCOP of phthalic anhydride with allyl glycidyl ether using mPEG-OH and t-BuP1/Et3B as the macroinitiator and binary catalyst, respectively. Subsequently, Rh moieties are covalently attached on the polymer chain with controllable grafting degree via an efficient thiol-ene click reaction. Concurrently, the effect of catalyst systems and reaction conditions on the catalytic copolymerization performance is presented, and the quantitative introduction of Rh is described in detail. Owing to its amphiphilic characteristics, the rhodamine-functionalized polyester-based block copolymer can self-assemble into micelles. With the covalent incorporation of Rh moieties, the as-formed micelles exhibit excellent absorption and fluorescence-responsive sensitivity and selectivity towards H+ in the presence of various metal cations. Moreover, the as-prepared micelles with favorable water dispersibility, good pH sensitivity and excellent biocompatibility also display appreciable cell-membrane permeability, staining ability and pH detection capability for lysosomes in living cells. This work provides a new strategy for the facile synthesis of novel biocompatible polymeric fluorescent pH nanosensors for the fluorescence imaging of lysosomal pH changes.
Optimization of Alkaline Activator on the Strength Properties of Geopolymer Concrete
Authors: Shilar Fatheali A. , Ganachari Sharanabasava V. , Patil Veerabhadragouda B. , Khan T. M. Yunus , Javed Syed , Baig Rahmath Ulla
Published: June 2022

This study investigates the effects of red mud on the performance of geopolymer concrete in regard to fresh and mechanical properties. Red mud was used as a binder, and GGBS replaced the binder. Different proportions of red mud ranging from 0 to 30% with an interval of 2% and activator agents such as KOH and K2SiO3 for various alkaline-to-binder ratios such as 0.30, 0.40, and 0.50 were used; their effect on the fresh and mechanical properties of geopolymer concrete were the focusing parameter on the current study. Fresh properties such as setting time, slump, compaction factor, and vee-bee consistometer test, and mechanical properties such as compressive strength, split tensile strength, flexural strength, modulus of elasticity, and impact energy were studied. ANOVA and radar plot analysis were studied for various alkaline to binder (A/B) compressive strength results tested for 7 to 90 days. The increase of red mud quantity caused the decline of workability, but there was continuous enhancement of mechanical properties of GPC up to a specific limit. An alkaline-to-binder ratio of 0.4 shows excellent results compared with other ratios at ambient conditions for strength properties. ANOVA and radar plot reveal that A/B of 0.40 for 90 days shows excellent results compared with other ratios, and CS values vary in a linear manner.
A Review of Lithium-Ion Battery Thermal Runaway Modeling and Diagnosis Approaches
Authors: Tran Manh-Kien , Mevawalla Anosh , Aziz Attar , Panchal Satyam , Xie Yi , Fowler Michael
Published: June 2022

Lithium-ion (Li-ion) batteries have been utilized increasingly in recent years in various applications, such as electric vehicles (EVs), electronics, and large energy storage systems due to their long lifespan, high energy density, and high-power density, among other qualities. However, there can be faults that occur internally or externally that affect battery performance which can potentially lead to serious safety concerns, such as thermal runaway. Thermal runaway is a major challenge in the Li-ion battery field due to its uncontrollable and irreversible nature, which can lead to fires and explosions, threatening the safety of the public. Therefore, thermal runaway prognosis and diagnosis are significant topics of research. To efficiently study and develop thermal runaway prognosis and diagnosis algorithms, thermal runaway modeling is also important. Li-ion battery thermal runaway modeling, prediction, and detection can help in the development of prevention and mitigation approaches to ensure the safety of the battery system. This paper provides a comprehensive review of Li-ion battery thermal runaway modeling. Various prognostic and diagnostic approaches for thermal runaway are also discussed.
Treatment of Sewage Sludge Compost Leachates on a Green Waste Biopile: A Case Study for an On-Site Application
Authors: Ibrahim Irka Chaher , Prudent Pascale , Théraulaz Frédéric , Farnet Da Silva Anne-Marie , Asia Laurence , Gori Didier , Vassalo Laurent , Durand Amandine , Demelas Carine , Höhener Patrick , Wong-Wah-Chung Pascal
Published: June 2022

This work proposes a suitable treatment for the leachates from a sewage sludge composting process using a specific windrow (biopile). The biopile’s evolution and organic content degradation were followed for 2 months with regular leachate spraying to assess the physico-chemical and biological impacts, and determine the risk of enrichment with certain monitored pollutants. The final objective was the valorization of the biopile substrates in the composting process, while respecting the quality standards of use in a circular economy way. Classical physico-chemical parameters (pH, conductivity, dissolved organic carbon (DOC), total dissolved nitrogen (TDN), etc.) were measured in the leachates and in the water-extractable and dry-solid fractions of the biopile, and the catabolic evolution of the micro-organisms (diversity and activities), as well as the enrichment with persistent organic pollutants (POPs) (prioritized PAHs (polycyclic aromatic hydrocarbons) and PCBs (polychlorinated biphenyls)), were determined. The results showed that the microbial populations that were already present in the biopile, and that are responsible for biodegradation, were not affected by leachate spraying. Even when the studied compost leachate was highly concentrated with ammonium nitrogen (10.4 gN L−1 on average), it significantly decreased in the biopile after 2 weeks. A study on the evolution of the isotopic signature (δ15 N) confirmed the loss of leachate nitrogen in its ammoniacal form. The bio-physico-chemical characteristics of the biopile at the end of the experiment were similar to those before the first spraying with leachate. Moreover, no significant enrichment with contaminants (metal trace elements, volatile fatty acids, or persistent organic pollutants) was observed. The results show that it would be possible for composting platforms to implement this inexpensive and sustainable process for the treatment of leachates.
Change: Thinking through Sāṅkhya
Authors: Timalsina Sthaneshwar
Published: June 2022

This paper explores the ways change is addressed in Sāṅkhya, one of the major Hindu schools of philosophy, specifically in light of the classical debate between Hindu and the Buddhist philosophers regarding intrinsic nature (svabhāva) and the concept of transformation (pariṇāma). When we closely analyze Sāṅkhya categories, the issue of temporality stands out, because for Sāṅkhya philosophers time is not a distinct category and is infrequently addressed in classical Sāṅkhya. Nonetheless, we can still extract two different notions related to time, dynamism intrinsic to rajas, and temporality that is enclosed within the notion of space and spatial objects. What this implies is that the temporality implicit within the concept of change is only applicable to the last of the evolutes, according to Sāṅkhya cosmology. However, the Sāṅkhyan idea of 16 transformations (pariṇāma) applies to all categories, except puruṣa. By exploiting the parameters of these arguments, this paper makes the case for a closer analysis of the category of transformation in classical Sāṅkhya. Reading about change in the light of svabhāva, the intrinsic nature of an entity, versus the idea of its termination, allows us to have a wider conversation on what it means for something to change from within the Sāṅkhya paradigm.
Religious Freedom, Cybersecurity, and the Stability of Society: Problems and Perspectives from a European Perspective
Authors: Roszak Piotr , Horvat Sasa
Published: June 2022

Although religious freedom significantly affects certain people, the guarantees for its observance also have implications for the quality of social life and the security of the state. Polarization and conflict between religious groups is not only a conflict for new believers, but also contributes to the weakening of the internal state. It seems that one of the elements of such a destabilization of states is the promotion and lack of reaction to the phenomenon of ridiculing religion and its followers in cyberspace. As can be seen from reports on the situation in Poland, there are increasing signs of hostility to religion, stereotyping, and discrimination. The issues can be considered on two levels: individual protection for freedom of speech, and state protection. At the end of this paper, proposals for measures to prevent crimes based on religion or belief are presented.
Ten Years of VIIRS Land Surface Temperature Product Validation
Authors: Liu Yuling , Yu Peng , Wang Heshun , Peng Jingjing , Yu Yunyue
Published: June 2022

The Visible Infrared Imaging Radiometer Suite (VIIRS) Land Surface Temperature (LST) has been operationally produced for a decade since the Suomi National Polar-orbiting Partnership (SNPP) launched in October 2011. A comprehensive evaluation of its accuracy and precision will be helpful for product users in climate studies and atmospheric models. In this study, the VIIRS LST is validated with ground observations from multiple high-quality radiation networks, including six stations from the Surface Radiation budget (SURFRAD) network, two stations from the Baseline Surface Radiation Network (BSRN), and 13 stations from the Atmospheric Radiation Measurement (ARM) network, to evaluate its performance over various land-cover types. The VNP21A1 LST was validated against the same ground observations as a reference. The results yield a close agreement between the SNPP VIIRS LST and ground LSTs with a bias of −0.4 K and a RMSE of 1.96 K over six SURFRAD sites; a bias of −0.2 K and a RMSE of 1.93 K over two BSRN sites; and a bias of −0.1 K and a RMSE of 1.7 K over the 13 ARM sites. The time series of the LST errors over individual sites indicate seasonal cycles. The data anomaly over the BSRN site in Cabauw and the SURFRAD site in Desert Rock is revealed and discussed in this study. In addition, a method using Landsat-8 data is applied to quantify the heterogeneity level of each ground station and the results provide promising insights. The validation results demonstrate the maturity of the JPSS VIIRS LST products and their readiness for various application studies.
Physics-Based TOF Imaging Simulation for Space Targets Based on Improved Path Tracing
Authors: Yan Zhiqiang , Wang Hongyuan , Liu Xiang , Ning Qianhao , Lu Yinxi
Published: June 2022

Aiming at the application of close-up space measurement based on time-of-flight (TOF) cameras, according to the analysis of the characteristics of the space background environment and the imaging characteristics of the TOF camera, a physics-based amplitude modulated continuous wave (AMCW) TOF camera imaging simulation method for space targets based on the improved path tracing is proposed. Firstly, the microfacet bidirectional reflection distribution function (BRDF) model of several typical space target surface materials is fitted according to the measured BRDF data in the TOF camera response band to make it physics-based. Secondly, an improved path tracing algorithm is developed to adapt to the TOF camera by introducing a cosine component to characterize the modulated light in the TOF camera. Then, the imaging link simulation model considering the coupling effects of the BRDF of materials, the suppression of background illumination (SBI), optical system, detector, electronic equipment, platform vibration, and noise is established, and the simulation images of the TOF camera are obtained. Finally, ground tests are carried out, and the test shows that the relative error of the grey mean, grey variance, depth mean, and depth variance is 2.59%, 3.80%, 18.29%, and 14.58%, respectively; the MSE, SSIM, and PSNR results of our method are also better than those of the reference method. The ground test results verify the correctness of the proposed simulation model, which can provide image data support for the ground test of TOF camera algorithms for space targets.
Landslide Inventory in the Downstream of the Niulanjiang River with ALOS PALSAR and Sentinel-1 Datasets
Authors: Wang Ziyun , Xu Jinhu , Shi Xuguo , Wang Jianing , Zhang Wei , Zhang Bao
Published: June 2022

Landslide inventory and deformation monitoring is an essential task for human life and property security during the exploitation process of hydroelectric power resources. Synthetic Aperture Radar Interferometry (InSAR) is recognized as an effective tool for ground displacement monitoring with the advantages of wide coverage and high accuracy. In this study, we mapped the unstable slopes in the downstream of the Niulanjiang River with 22 ALOS PALSAR SAR images acquired from 2007 to 2011, and 90 Sentinel-1 SAR images from 2015 to 2019. A total of 94 active slopes are identified using a displacement map from the two datasets based on Small BAseline Subset (SBAS) InSAR analysis. By comparing the results from ALOS PALSAR and Sentinel-1 data stacks, we find that the number of active slopes increased dramatically. Several impact factors, e.g., earthquake, concentrated rainfall, and construction of hydropower stations, are discussed through time series analysis of typical landslides. Furthermore, nonlinear displacement of natural unstable slopes are found to be correlated with rainfall. A climate-driven model is used to qualify the relationship between rainfall and landslide displacement. Our results can provide valuable information for landslide detection and prevention.
The Importance of Outdoor Spaces during the COVID-19 Lockdown in Aotearoa—New Zealand
Authors: Marques Bruno , McIntosh Jacqueline , Muthuveerappan Chitrakala , Herman Krzysztof
Published: June 2022

The novel Coronavirus (COVID-19) outbreak and its extensive variants have caused drastic changes to people’s habits and routines in many countries worldwide, including Aotearoa—New Zealand. The levels of lockdown and/or movement limitations affected how people used outdoor spaces, often keeping them away from nature’s benefits. The COVID-19 pandemic and the measures adopted to control it provide an interesting experiment investigating the links between nature exposure, recreational use of outdoor spaces, and people’s health and wellbeing under extreme conditions. Using an online survey distributed during lockdown and based on 212 responses, this article explores the different typologies of the outdoor spaces that people had access to during lockdown and the associated physical activities practised. It investigates how outdoor space affects our emotional response and how such space and related activities can help us cope with confinement. The results of this study enable us to better understand those spatial elements and characteristics of outdoor spaces that are essential to people’s wellbeing, especially in unusual circumstances where access is restricted.
Urban–Rural Partnership Perspectives in the Conceptualization of Innovative Activities in Rural Development: On Example of Three-Case Study Analysis
Authors: Kusio Tomasz , Rosiek Janusz , Conto Francesco
Published: June 2022

The idea of smart villages, though arising from the smart cities concept, seems to influence the rural reality as well, and this may, among others, be the effect of urban–rural partnerships. The smartness of villages, as it is significantly related to the innovative concepts in rural regions, refers to the innovative solutions which, in order to be implemented, need to go beyond the rural authorities and engagement of rural stakeholders. The main objective of the manuscript is to assess the role of partners from urban centers in the concepts of local development of rural areas in order to find the potential for future cooperation. As such, the evidence is based on the initiatives from three different agricultural regions located in Southern Poland, where engaged local stakeholders have commenced innovative activities. The research has been conducted based on an explanatory multi–case study method. These research findings reveal that despite direct lack of urban participation in the innovative developmental idea’s conceptualization, the need for and presence of urban partners exists, especially when the implementation is concerned. Additionally, the presence of urban support seems to be indirectly perceived by rural leaders, especially as the phenomenon of adaptation to the rural environment for the urban newcomer is recognized by the rural residents. The need for support from cities is first of all recognized in the following areas: content, obtaining financial resources for the implementation of projects developed by them, and choosing an appropriate organizational and legal form of implemented initiatives.
Spatial Differentiation and Impact Factors of Tourism Development: A Case Study of the Central Plains, China
Authors: Kang Jiayu , Duan Xuejun , Yan Wei , Ma Zhiyuan
Published: June 2022

This study aims to summarize the patterns of spatial differentiation and impact factors on tourism development. This research used the Central Plains as the study area to analyze the spatial differentiation patterns of tourism development from 2005 to 2018. The study used spatial econometric methods, such as the spatial Durbin model and the geodetector model, to explore the impact factors of tourism development. According to the results, the spatial differentiation characteristics of domestic tourism and inbound tourism were similar, and the spatial agglomeration of both had significantly narrowed. The study also found impact factors in the study have a differential influence on domestic tourism and inbound tourism, with a strong spatial spillover effect on domestic tourism compared to inbound tourism. For a long time, domestic tourism has been impacted mainly by tourism policies and economic levels, inbound tourism has been impacted by tourism policies, and the level of openness to the outside world does not have a major impact on inbound tourism. Reasonable explanations are provided for these results and policy implications are drawn.
(Un)Sustainable Human Resource Management in Brazilian Football? Empirical Evidence on Coaching Recruitment and Dismissal
Authors: Galdino Matheus , Lesch Lara , Wicker Pamela
Published: June 2022

A superficial attitude in football insists on blaming head coaches when games are lost. Controversially, however, whereas decision-makers in professional football clubs claim to seek successful outcomes on the pitch, they often favor questionable judgements that affect their organizational sustainability by recycling coaches without substantial analyses. Albeit scholars have stressed potential causes and consequences of coaching turnovers, specific knowledge is needed around the recruitment and dismissal steps faced by professional coaches, and to what extent their experiences mirror the theoretical background of human resource management in sport. This study poses the following research question: how do football clubs actually handle coaching recruitment and dismissal processes? Qualitative, semi-structured interviews were conducted with 26 elite coaches from Brazil, who had collectively been employed by all 43 clubs that participated in the Brasileirão from 2003 to 2020. Based on a deductive-inductive approach, the content analysis framed two categories (recruitment and dismissal stages) with three main themes (methods, decision-makers, and decision-making), which were sustained by specific subthemes. The results suggest how the recruitment, assessment, and replacement of head coaches neglect both a strategic and a sustainable rationale towards human resource management in Brazil’s elite football.