bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH PERSEDIAAN BAHAN BAKU DAN TENAGA KERJA TERHADAP VOLUME PRODUKSI PADA PT BUKIT INTAN ABADI DI MEDAN
Authors: Aisyah Siti , Rangkuti Sahnan , Antoro Budi
Published: December 2024

The availability of sufficient raw materials of good quality and support from qualified and highly committed workers will significantly determine the achievement of the targeted production volume. PT. Bukit Intan Abadi, as the locus of this research, is a company engaged in the wood sector with plywood as its main product. This study intends to determine the effect of raw material supply and labor on PT Bukit Intan Abadi production volume. This quantitative study uses data collection techniques carried out by observation, documentation studies, interviews, and questionnaires, with multiple linear regression data analysis techniques, t-tests, F-tests, and determination tests. The survey results with the t-test showed that the t-value of the raw material inventory variable was 4.526 t-count> t-table (4.526> 1.66757). The raw material inventory variable positively and significantly affects PT Bukit Intan Abadi Belawan's production volume. Furthermore, for the labor variable, the t-count value is known (13,322> 1.66757). It means that the labor variable positively and significantly affects production volume. Meanwhile, the results of the F test show that the F-count value is 96,330 compared to F-table 3.13, so F-count> F-table (96,330> 3.13). This means that the raw material and labor inventory variables positively affect PT Bukit Intan Abadi's production volume. Furthermore, the results of the determination test show that the R Adjust Square value is 0.742 or 74.2%. This means that raw materials and labor inventory can affect production volume by 74.2%, while the rest is influenced by other factors that have yet to be studied
Assessing Digital Competence Among Health Science Undergraduates: a Critical Analysis
Authors: Herrera-Lillo Antonieta , Urrejola-Contreras Gabriela
Published: December 2024

Introduction. Strategic management between the educational realm and technology is possible as long as teachers and students have adequate and timely development of digital competencies. Although current generations are receptive to technology, academic activities that require critical thinking and problem-solving with digital support pose challenges and sometimes difficulties.
Objective. To assess digital competencies in students from various healthcare disciplines through self-perception.
Method. The Questionnaire for Assessing Student Digital Competence in Higher Education was used to gather information from a sample of 186 students in the healthcare field. Subsequent analysis was conducted using descriptive statistics.
Results. The results indicated that, overall, students rated themselves in an intermediate range in terms of digital competence, suggesting a moderate perception of their digital abilities.
Conclusion. Although most students reported having basic digital skills, many perceived challenges when using technology for academic tasks requiring information management, research, critical thinking, creativity, and innovation. Continuously improving students' digital competence and guiding their use of technology to solve complex problems can add significant value in the field of e-health, preparing them to fully leverage the opportunities technology offers in academic and professional settings.
Comparative Analysis of Machine Learning Models for Prediction of Reference Evapotranspiration
Authors: Milić Miljana , Jeremić Miljan , Milojković Jelena , Lukač Duško
Published: December 2024

Research described in this paper gives a comparative analysis of two different machine learning models, notably RNN (Recurrent Neural Network) and SARIMA (Seasonal Auto Regressive Integrated Moving Average), in order to determine the most effective tool for predicting reference evapotranspiration (ET0) in a specific scenario. The study uses historical evapotranspiration data collected over an extended timeframe. To quantify the accuracy and reliability of the forecasts, metrics like Mean Absolute Error (MAE), Mean Squared Error (MSE), and Root Mean Squared Error (RMSE) are employed. Through this analysis, the study highlights the strengths and weaknesses of both SARIMA and RNN models, which are useful tools in the field of environmental science.
Menguji Batas Business Judgement Rule: Studi Kasus Pengembangan Bisnis Lng PT Pertamina di Amerika Serikat
Authors: Wijayanto Budi Tri , Andini Siska Dwi
Published: December 2024

Business decisions made by the directors of a company are often the subject of legal interpretation, especially when the decision results in losses to the company or the state. This research focuses on the application of the Business Judgement Rule (BJR) principle in the case of LNG business development by PT Pertamina in the United States involving Karen Agustiawan as President Director. Through a normative juridical approach and qualitative analysis, this study evaluates the extent to which the BJR can protect the board of directors from lawsuits as well as identify the factors that cause the decision not to be protected by the BJR principle. The results of the analysis show that the application of BJR cannot provide legal protection if the business decision is not based on good faith, prudence, and without conflict of interest. In this context, the study also discusses the application of progressive legal theory as an alternative framework for handling this kind of case. The study recommends strengthening regulations to set limits on BJR implementation and ensure transparency in the business decision-making process.
Ağır Metal Maruziyetinin Detoksifikasyonunda Tıbbi Aromatik Bitkilerin Terapötik Etkileri
Authors: Nizamlıoğlu Mustafa , Öncel Hasan Uğur , Nizamlıoğlu Fatma
Published: December 2024

Ağır metaller için standart bir tanım bulunmamakla birlikte, nispeten yüksek yoğunluklara, atom ağırlıklarına veya atom numaralarına sahip metaller grubunda yer alan elementlerdir. Günümüzde ağır metallerin endüstri, tarım, tıp ve teknolojideki çeşitli kullanımları, doğada yaygın bir dağılım göstermelerine yol açarak insan sağlığı ve çevre üzerindeki etkileri konusunda endişeleri artırmıştır. Bu yüzden modern yaşam ile birlikte ne yazık ki sadece belirli işlerde çalışanlar değil aynı zamanda günlük hayatın içinde de ağır metallere maruz kalma yaşanmaktadır. Ağır metaller, insanlarda zamanla “vücut metal yükü” oluşturur. Sonuç olarak, ağır metallere sindirim, solunum ve deri teması yoluyla maruz kalınması kardiyovasküler hastalıklar, nörolojik ve nörodavranışsal anormallikler, diyabet, kan anormallikleri ve çeşitli kanser türleri gibi çeşitli sağlık sorunlarına neden olmaktadır. Sağlık problemlerinin birçoğunun arkasında araştırılması gereken ilk şeylerden biri ve belki de en önemlisi vücutta ağır metal zehirlenmesi olup olmadığıdır. Ağır metal zehirlenmesinin vücudun çeşitli organlarında yol açtığı geniş çaplı hasar nedeniyle, ağır metallerle zehirlenmeye yönelik tedavi yöntemlerinin araştırılması ve belirlenmesi çok önemlidir. Ağır metallerin vücuttan uzaklaştırılması için en yaygın yöntem kimyasal şelatörlerin uygulanmasıdır. Son zamanlarda şifalı bitkiler, daha az yan etkiye sahip olmaları nedeniyle ağır metal zehirlenmelerinde potansiyel tedavi yöntemi olarak araştırmacıların dikkatini çekmiştir. Bu çalışmada, Allium sativum (sarımsak), Silybum marianum (deve dikeni), Coriandrum sativum (kişniş), Ginkgo biloba (gingko), Curcuma longa (zerdeçal), fitokelatinler, triphala, bitkisel lifler ve Chlorophyta (yeşil algler) gibi şifalı bitkilerin ağır metal zehirlenmesini tedavi etme potansiyeli PubMed ve SCOPUS veri tabanlarından elde edilen yayınlara dayanarak ve yazarların mesleki ve kişisel deneyimleri ele alınarak incelenmiştir.
İstanbul’da Satışa Sunulan Tavuk Dönerlerinde Clostridioides difficile Varlığının ve Antimikrobiyal Duyarlılıklarının Belirlenmesi
Authors: Bilgin Aslıhan , Akkaya Esra , Bingöl Enver Barış
Published: December 2024

Clostridioides difficile, gram (+), anaerob, sporlu, çomak şeklinde bakteri olup özellikle uzun süreli antibiyotik kullanımı sonucunda psödomembranoz kolit, toksik megakolon, intestinal perforasyon ve diareye sebep olmaktadır. Hastane kaynaklı olan etken toprakta, suda, su ürünlerinde, kasaplık hayvanlarda ve kanatlılarda tespit edilmiş olup, bu durum gıdaların C. difficile için potansiyel yeni rezervuarlar olabileceğini düşündürmektedir. Özellikle son yıllarda insanlardan izole edilen C. difficile suşlarının kasaplık ve kanatlı hayvanlarda da saptanması bu etkenin halk sağlığı yönünden ciddi bir risk oluşturabileceği kaygısını doğurmuştur. Bu doğrultuda, İstanbul’da satışa sunulan 128 tavuk döner örneği C. difficile varlığı yönünden analiz edilmiş ve bunlardan 12’si C. difficile şüpheli olarak tespit edilmiştir. Şüpheli 12 örnekten sadece 2’si (%1.56) C. difficile olarak doğrulanırken, her iki izolatın da vankomisin ve sefotaksime dirençli olduğu saptanmıştır. Sonuç olarak, tavuk döner örneklerinden izole edilen C. difficile suşları, etkenin kanatlı hayvan karkaslarının yanı sıra bunlardan elde edilen hayvansal kökenli gıdalarda da bulunabildiğini ve pişirme sıcaklıklarına da dirençli olabildiğini göstermiştir.
Gıda Endüstrisinde Bakteriyel Biyofilm Oluşumu, Kontrolü ve Giderilmesine Yönelik Yeni Uygulamalar
Authors: Kayaardı Semra , Uyarcan Müge , Turan Havva
Published: December 2024

Gıda zincirinde hammaddenin işletmeye girmesinden son ürün elde edilinceye kadar üretimin tüm aşamalarında ekipmanların yeterince temizlenmemesi ve uygun hijyen standartlarının ihmal edilmesi gibi nedenlerle çeşitli kaynaklardan kontaminasyon riski söz konusudur. Gıda işletmelerinde yaşanan kontaminasyon riskleri sadece ürün kalitesini değil aynı zamanda gıda güvenliğini ve tüketici sağlığını etkileme potansiyeline sahiptir. Kontaminasyonu önlemeye yönelik yapılan temizlik ve dezenfeksiyon uygulamalarında yaşanan en büyük zorluklardan biri ekipman yüzeylerinde bakteriyel kaynaklı biyofilm oluşumudur. Biyofilmler bir yüzeye yapışarak kendi ürettikleri polimerik yapı içinde yaşayan mikroorganizmaların oluşturduğu jelsi bir tabaka olarak tanımlanmaktadır. Özellikle gıda işletmelerinde ekipman ve boruların iç yüzeyleri, filtreler, konveyör bantlar, yardımcı alet ve ekipmanlarda, temizlenmesi ve dezenfekte edilmesi zor olan alanlarda gelişerek gıdalarda bozulmalara neden olmakla birlikte ciddi ekonomik kayıplara yol açmaktadır. Bu yüzden gıda işletmelerinde biyofilm oluşumunun engellenmesi ya da engellenemediği durumlarda da ortadan kaldırılması gerekmektedir. Son zamanlarda güncel çalışmalar biyofilmlerin endüstriyel ortamlardan giderilmesi veya oluşumunun engellenmesi için mevcut yöntem ve stratejilerin iyileştirilmesiyle birlikte daha etkili inhibitör ajanlar veya uzaklaştırma tekniklerinin geliştirilmesine odaklanmıştır. Biyofilmlerin kontrolünde son uygulamalar arasında soğuk atmosferik plazma, yüksek basınç, vurgulu ışık, elektrolize su, ozon, ultrason gibi yeşil teknolojiler ile bakteriyofaj ve bakteriyosin uygulamaları yer almaktadır. Biyofilm engel teknolojilerine bakıldığında bakterisidal yüzey teknolojileri ve nanoteknoloji gibi yeni teknikler üzerine güncel çalışmalar devam etmektedir. Bu çalışmada bakteriyel biyofilm oluşumu ve gelişimi, etkileyen faktörler, önlemeye yönelik stratejiler ile her şeye rağmen oluşumu engellenemeyen biyofilmlerin gıda güvenliği, tüketici sağlığı, ekipman ve yüzeylere zarar vermeyecek ileri tekniklerle en etkili şekilde giderilmesine yönelik uygulamalar derlenmiştir.
Gıda Endüstrisinde Küresel Plastik Kirliliği: Mikro-Nanoplastikler ve Çevresel Etkileri
Authors: Uyarcan Müge , Güngör Sude Cansın
Published: December 2024

Son yıllarda gıda ambalajlamada petrol bazlı plastik kullanımının ham madde kaynağının bulunabilirliği, düşük maliyet, iyi yalıtım, zayıf elektrik/ısı iletkenlik ve korozyon direnci, hafiflik, yüksek mukavemet ve çok yönlü üretilebilirlik gibi çeşitli faktörler nedeniyle arttığı görülmektedir. 2022 yılında toplam plastik üretimi 400.3 milyon metrik ton olarak gerçekleşirken, plastik atık üretimi 300 milyon metrik ton seviyesine ulaşmıştır ve plastik atıkların sadece %14'ünün geri dönüştürüldüğü rapor edilmiştir. Bu üretim verilerinin arasında gıda ambalajları fosil yakıtlardan elde edilen plastiklerin %50'sini oluşturmaktadır. Plastik ambalajlar gıda endüstrisinde uzun süredir kullanılmasına rağmen kararlılıkları, dayanıklılıkları ve biyobozunur olmamaları sebebiyle çevreye zarar vermektedir. Plastik üretiminde genellikle ham madde olarak ham petrol, gaz ve kömür gibi fosil yakıtlar kullanılmaktadır. Fosil yakıtlar, çevre kirliliği ve toksik sera gazlarının (metan ve etilen) başlıca kaynaklarıdır. Günümüzde plastik üretiminden kaynaklanan bu yakıtların dünya genelinde yüksek bir oranda tüketilmesi, ciddi olumsuz sonuçlar doğurmaktadır. İklim ve mevsim düzenindeki değişiklikler, buzulların geri çekilmesi ve yükselen deniz seviyeleri dahil olmak üzere olumsuz sonuçlar meydana getirmektedir. Ayrıca parçalara ayrıldıklarında mikroplastiklere ve nanoplastiklere dönüşmekte, bunlar da nihayetinde besin zincirine girerek, insanlar ve çevredeki diğer canlılar için sağlık sorunları oluşturmaktadır. Mikroplastikler ve nanoplastikler, plastik kaynaklı kirleticiler arasında son yıllarda en fazla dikkati çeken konu olmuştur. Mikro ve nanoplastik formlarındaki plastikler, boyutlarının çok küçük olması (mikroplastik (
Şırnak'ta Satışa Sunulan Pırtıga Bige (Ferulago stellata) Bitkisinin Mikrobiyolojik Kalite Parametreleri
Authors: Erkan Mehmet Emin , Uçar Uğur , Duman Aydın Berna
Published: December 2024

Ferulago stellata beşeri hekimlikte bazı hastalıklara karşı kullanılan şifalı bir bitki türüdür. Dünyada bilinen 28000 bitki taksonunun tıbbi değere sahip olduğu rapor edilmiştir. 3000'den fazla türün kanser ve diyabet başta olmak üzere birçok hastalığa karşı etnomedikal kullanım ve uygulamalarının olduğu bildirilmektedir. Türkiye'nin Doğu ve Güney Anadolu Bölgesi'nde doğal olarak yetişen endemik olmayan bir bitkidir. Kuzey İran ve Kuzey Irak’ta da yetişebilen bu bitki Şırnak ilimizde dağ yamaçlarında 1650-2800 m yükseklikteki alanlarda yetişir ve halk arasında “Pırtıga bige”, “Bük”, “Nerbig” olarak adlandırılır. Halk arasında geleneksel otantik gıda olarak tüketilen Ferulago stellata'nın antidiyabetik, antikolinerjik, antioksidan, antienflamatuar ve antimikrobiyal etkilerinin olduğu bildirilmektedir. Bu çalışmada, Şırnak il merkezi ve ilçelerinden farklı dönemlerde toplanan 36 Pırtıga bige örneğinin mikrobiyolojik kalite parametreleri incelenmiştir. Örnekler Toplam Mezofilik Aerobik Bakteri (TMAB), koliform bakteri, Escherichia coli, Staphylococcus-Micrococcus spp., Listeria monocytogenes, Salmonella spp., Yersinia enterocolitica, Lactobacillus spp., küf, maya ve sülfit indirgeyen anaerobik bakteriler açısından analiz edilmiştir. Salmonella spp., Listeria monocytogenes ve Yersinia enterocolitica Pırtıga bige numunelerinde tespit edilemezken, Escherichia coli, koliform bakteri ve sülfit indirgeyen anaerobik bakteriler sırasıyla örneklerin %52.77, %63.88 ve %27.77'sinde tespit edilmiştir. Şırnak'ta satışa sunulan Pırtıga bige örneklerinin mikrobiyolojik kalitesinin çok düşük olduğu ve bu durumun potansiyel bir sağlık riski oluşturduğu tespit edilmiştir. Bu tür gıdaların fonksiyonel özelliklerinin daha kapsamlı araştırılması gerekmektedir. Pırtıga bige üretiminin daha hijyenik koşullarda yapılması ve organik olan bu ürünlerin tanıtımının yapılması gerekmektedir.
Chickenpox Childhood Disease: An insight from Mathematical Modelling
Authors:   Department of Pure and Applied Mathematics,Ladoke Akintola University of Technology, Ogbomoso, Nigeria, Adepoju O. A. , Ibrahim H. O. ,   Department of Pure and Applied Mathematics,Ladoke Akintola University of Technology, Ogbomoso, Nigeria, Adetunji J. A. ,   Department of Pure and Applied Mathematics,Ladoke Akintola University of Technology, Ogbomoso, Nigeria, Olanrewaju S. O. ,   Department of Pure and Applied Mathematics,Ladoke Akintola University of Technology, Ogbomoso, Nigeria
Published: December 2024

Chickenpox is an infectious disease that causes an itchy, blister-like rash on the skin and can spread through bodily fluids and body contact. This study presents a mathematical model for the transmission dynamics of chickenpox among children by considering the impact of vaccination and treatment. The qualitative analysis of the model reveals that the model has two equilibrium points, namely: the chickenpox-free and endemic equilibrium points. The disease-free equilibrium point is globally asymptotically stable whenever the basic reproduction number is less than unity (R0<1) and the endemic equilibrium point is globally stable whenever the reproduction number is greater than unity (R0>1). The normalized forward sensitivity index is also used to obtain the critical factors responsible for the transmission of chickenpox in the population. Furthermore, it reveals that parameters with negative indices will reduce the transmission of chickenpox when increased. The qualitative analysis of the model is supported by numerical simulation
Understanding Driver Performance: The Mediating Impact of Discipline on Motivation, Skills, and Work Culture at PT Hiba Logistic
Authors:   Faculty of Economics and Business, University of Jember, Indonesia, Udhayanto Rekly Arief Sidharta , Handriyono Handriyono ,   Faculty of Economics and Business, University of Jember, Indonesia, Awwaliyah Intan Nurul ,   Faculty of Economics and Business, University of Jember, Indonesia
Published: December 2024

This study investigates the mediating role of discipline in the relationship between motivation, work skills, work culture, and drivers' performance at PT Hiba Logistic (Hilog). Utilizing an explanatory research design, this study explores causal relationships among the variables to test hypotheses and uncover new insights. The independent variables include motivation (X1), work skills (X2), and work culture (X3), with discipline (Z) serving as the mediating variable and performance (Y) as the dependent variable. Structural Equation Modeling with Partial Least Squares (SEM-PLS) was employed for data analysis using the SmartPLS 4.0 application. The findings reveal the following: (1) motivation significantly influences discipline, (2) work skills do not significantly influence discipline, (3) work culture significantly influences discipline, (4) motivation does not significantly influence performance, (5) work skills do not significantly influence performance, (6) work culture significantly influences performance, (7) discipline significantly influences performance, (8) discipline significantly mediates the relationship between motivation and performance, (9) discipline does not significantly mediate the relationship between work skills and performance, and (10) discipline significantly mediates the relationship between work culture and performance. These findings provide practical insights into the critical role of discipline in driver performance and its implications for enhancing workplace dynamics. e job skills, and performance variables [10]. Discipline has a significant effect on mediating work culture and performance variables
Nephrotoxicity of Iodinated Contrast Drugs: A comparative Analysis of Old Versus New, Ionic Versus Non Ionic Agents, Dose Effects, and the Impact of Relative Dehydration in Stroke Patients
Authors:   Department of Pharmaceutical Services, University College Hospital IbadanIbadan, Oyo State, Nigeria, Ajoyemi ALA Oluwafemi
Published: December 2024

Stroke is a type of cerebrovascular disease that impairs the
functionality of the brain due to disturbance in the blood supply
to the brain. There is approximately 1 stroke every 40 seconds,
amounting to it being a leading cause of serious long-term
disability [1]. It accounts for about 140,000 deaths annually
with an incidence rate of 795,000 each year, necessitating need
for prompt and accurate diagnosis and intervention. Stroke can
either be hemorrhagic or ischemic in nature. Hemorrhagic stroke
is when there is rupturing of blood vessels in the blood vessels
in the brain and its majorly treated by reducing blood pressure
in the brain or use of ‘pro-hemostasis’ medications. Ischemic
stroke is when there is occlusion of the blood vessels supplying
blood to the brain leading to shortage (hypoxemia) or no supply
of blood supply (hypoxia) in the brain. It is majorly treated with
thrombolytic medications that break down clots and must be
administered early to prevent risk of dangerous bleeding or use
of mechanical thrombectomy
Regulation of Rainwater in Quyuan Park Using the SWMM: A Case of Changde City, China
Authors: Siqing Huang , Ahmad Che Bon
Published: December 2024

This study focuses on Quyuan Park in Changde City, Hunan Province, China, and compares two development scenarios: one without a sponge facility and one with a combined sponge facility. The SWMM model was used to simulate total runoff, peak flow, and peak time under 2-hour rainfall events with recurrence periods of 1 year, 3 years, 5 years, and 10 years. The results demonstrate that the SWMM model can accurately quantify the runoff reduction performance of various sponge facilities, providing a reliable theoretical foundation and data support for addressing urban stormwater management challenges. The findings highlight the significant advantages of sponge facilities in reducing runoff and delaying flood peaks, particularly in controlling peak flow and extending the peak occurrence time. This study offers valuable data and insights for advancing the application of sponge city strategies to mitigate urban flooding.
Mağrib ve Kuzey Afrika’da Geleneksel Hafızlık Usulü: Tarihsel Gelişim ve Yöntem
Authors: Salihoğlu Alaaddin
Published: December 2024

Endülüs, Mağrib ve Kuzey Afrika bölgeleri, İslâm tarihinde hafızlık ve resmü’l-mushaf konusunda metodik yaklaşımları ve titiz uygulamalarıyla temayüz etmişlerdir. Bu sahalarda öncü roller üstlenerek, kırâat ilminin geli-şimine kayda değer katkılarda bulunmuşlardır. Mağribîlerin bu konulardaki uzmanlığının ve üstünlüğünün en somut göstergesi; günümüz İslâm dünya-sında basılan mushafların sonunda yer alan tanıtım sayfalarında, ilgili mus-hafların kitabeti ve zaptı konusunda referans olarak kullanılan kaynakların, Batı İslâm coğrafyasında yetişen âlimler tarafından telif edilmiş olmasıdır. Bu üstünlüğün ardında yatan sebeplerden biri bölgede asırlardır süregelen geleneksel tahta levha merkezli hafızlık yöntemidir. Çalışmada, Mağrib ve Kuzey Afrika bölgesindeki levhalarla hafızlık geleneği ele alınmış, bu gele-neğin tarihsel gelişimi ve İslâm’ın bölgede yayılmasıyla başlayan eğitim süre-ci incelenmiştir. Ardından, bölgedeki Kur’ân eğitimi veren kurumlar hak-kında bilgi verilmiştir. Sonraki başlıkta, hafızlık eğitimi sürecinin üç temel merhalesi detaylandırılmış ve yöntemin farklı uygulamaları açıklanmıştır. Daha sonra, tahta levha merkezli hafızlık metodunun özellikleri üzerinde durulmuştur. Bu yöntemin görsel ve işitsel boyutları nasıl bütünleştirdiği, arz, semâ‘ ve kitabet unsurlarını nasıl birleştirdiği, Kur’ân’ın sonundan baş-lama yaklaşımının avantajları ve çoklu zekâ teorisiyle uyumu gibi konular ele alınmıştır. Ayrıca çalışmada, bu ezber yönteminin hafızlık ile resmü’l-mushaf arasında köprü rolünü üstlenen tenzîl ve ansâs uygulamaları da in-celenmiştir. Bunun yanı sıra çalışma kapsamında geleneksel hafızlık eğiti-minde kullanılan eğitim materyalleri hakkında bilgi verilmiş ve bu araç-gereçlerin bölgesel dini ve kültürel bağlamdaki sembolik anlam ve önemi ortaya konmaya çalışılmıştır. Yöntem açısından, bu araştırma mukayeseli analiz ve literatür taraması yöntemlerini benimsemiştir.
Arap Yazı Dilinde İmlâ Kurallarının Cümle Öğelerini Belirlemedeki İşlevi
Authors: Durmuş İshak
Published: December 2024

Geçmişten günümüze Arap yazı dilinde iki önemli sistem değişikliği meydana gelmiştir. Bunlardan birincisi birbirine benzeyen harflerin farklı biçimde noktalanmasıdır. İslam’ın ilk dönemlerinden itibaren birbirine ben-zeyen harfleri ayırt etmek için noktalama yaygın bir şekilde kullanılmış ve zamanla bu noktalar geldikleri harf ile bütünleşerek günümüz Arap alfabe-sini oluşturmuştur. İkincisi ise diğer dillerde sesli harflere karşılık gelen hare-kelerin yazılı dilde çeşitli semboller ile gösterilmesidir. Bu semboller ortaya çıktıkları ilk dönemler de dahil olmak üzere günümüzde sadece belli başlı kitaplarda ve durumlarda kullanılmaktadır. Bu iki alandaki tüm çalışmalar Arap yazısındaki kelime ve cümlelerdeki telaffuz farklılığını ve buna bağlı olarak herhangi bir kelime veya cümledeki olası çok anlamlılığı azaltmak amacıyla yapılmıştır. İmlâ da bu hedefle ortaya konulmuş bir ilimdir. Nokta-lama ve harekeleme çalışmalarından farklı olarak imlâ kurallarının temelini ise yazımda birbirine benzeyen farklı anlamdaki kelimeleri birbirinden ayır-mak için bazı harflerin ziyadesi, hazfi ve tebdîli bunlara ilaveten bazı keli-melerin vaslı ve faslı ile ilgili kurallar oluşturmaktadır. Bu kurallar incelen-diğinde bir kısmının cümle öğelerini belirlemede birtakım kolaylıklar sağla-dığı görülmektedir. Bu bağlamda çalışmanın amacı Arap yazı dilinde imlâ kurallarının cümle öğelerini belirlemedeki işlevini örnekler üzerinden göste-rerek bu kuralların dilbilimsel yönden önemini vurgulamaktır.
Psychological health in health care workers: features of the formation of professional burnout, prevention opportunities
Authors: Yatsyna Irina V. , Sheenkova Maria V.
Published: December 2024

Introduction. The working conditions in medical workers are characterized by high tension, which leads to a violation of the psycho-emotional state in health care workers, including professional burnout, the features of which depend on the neurophysiological type of personality, the severity of chronic stress, and the level
of commitment to a healthy lifestyle.
The purpose is to identify risk factors for professional burnout and evaluate the effectiveness of preventing professional burnout in medical workers in conditions
of increased work intensity.
Materials and methods. The study included medical workers with indices of the intensity of the labour process of class 3.1 and 3.2. The questionnaire method was used to determine: the features of the formation of professional burnout, characteristics of the type of nervous system, the index of adherence to a healthy lifestyle, stress level, subjective assessment of the psychological state. The analysis of the trend in indices of professional burnout and psychological state after group psychosomatic correction sessions was carried out.
Results. The structure of professional burnout in medical workers was dominated by high rates of reduction of professional achievements (53.8%), the frequency of emotional exhaustion was 25.6%, depersonalization – 30.8%. The probability of developing emotional exhaustion in persons with an average strength of the nervous system was 3.8 times higher than in persons with a strong type of nervous system. A lack of commitment to a healthy lifestyle is associated with an increased frequency of emotional exhaustion. The positive trend in indices of professional burnout and subjective assessment of the psychological state after the preventive program of resonant acoustic vibrations has been achieved.
Limitations. The subjects were employees of a medical institution working under conditions of exposure to the intensity of the labour process exceeding hygienic standards. The data is limited to voluntary study participants.
Conclusions. The features of the formation of professional burnout in medical workers are determined. The effectiveness of the program for the prevention of professional burnout with the use of group psychosomatic correction has been confirmed.
the problem of the formation of a new indicator pathology in children during the implementation of the "digital school"
Authors: Efimova Natalia V. , Mylnikova Inna V.
Published: December 2024

Introduction. An innovative digital educational environment is one of the significant factors in the school.
The purpose is to study the trend in newly identified morbidity in certain classes of diseases and nosological forms during the total implementation of distance learning in schoolchildren.
Materials and methods. The incidence rates of indicator diseases in 5–9, 10–14 and 15–17 years children per 1000 people for 2016–2022 were calculated. Linear regression and comparative (Fisher’s exact test) analyzes were used. Relative risk of incidence (RR with 95% confidence interval (CI) and S score error) was calculated for the distance learning period.
Results. The maximum incidence was noted for the musculoskeletal system (5–9 – 164.5 ‰, 10–14 – 212.0‰ and 15–17 – 108.3‰). Trends in increasing incidence were established in 5–9 and 10–14 years children for disorders of the autonomic nervous system and lesions of the synovial membranes and tendons (R² > 0.7). The RR of obesity ranged from 1.077 to 1.772; lesions of synovial membranes – 1.352–1.845 for children in all age groups in 2021–2022. RR myopia is registered in 15–17 and 5–9 years children.
Limitations are related to the lack of information on the use of electronic devices during education over 2016–2017 and the intensity of their use of electronic devices in the process of leisure activities.
Conclusion. With the widespread introduction of digital technologies and distance learning into educational activities, pathomorphism of school indicator diseases is observed, which determines the need to develop new medical and pedagogical approaches to the prevention of children’s health disorders.
Modern characteristics of the health status in higher education students and factors shaping it (literature review)
Authors: Shestera Albina A. , Trankovskaya Lidiya V. , Kaptsov Valery A. , Nagirnaya Lyudmila N.
Published: December 2024

The economic development of a state is largely determined by an effective system of training highly qualified personnel and is greatly influenced by the health status in young people. Students are constantly under the influence of a complex of factors: socio-economic, environmental, medical-biological, climatic-geographical, and others, the combined impact of which can lead to both improvement and deterioration of their health. Consequently, studying the risk factors affecting the health in students is a relevant direction and the basis for effective primary prevention of adverse factor influences during the learning period.
The aim of this work is to examine the current aspects of modern students’ health status and the factors affecting it.
To achieve this goal, an analysis of literary data included in the databases “Scopus”, “Web of Science”, “PubMed”, “eLibrary”, and “Cyberleninka” was conducted. The search was carried out using queries “Student morbidity”, “Student health”, and “Risk factors”.
As a result, it was established that the health status in student youth is deteriorating. Medical students have lower health indices compared to students from other universities. Climatic-geographical and ecological features of the region (using Primorsky Krai as an example) was shown to be potent of causing specific deviations in the health status of young people. Thus, despite active research conducted in recent years on the problem of student health status, determining the factors influencing its formation, and developing and implementing preventive measures remains an unresolved task. This problem requires further research, especially in the regional aspect.
Analysis of the danger of cultured meat
Authors: Shur Pavel Z. , Barg Anastasiya O. , Suvorov Dmitry V. , Zelenkin Sergey E. , Lir Darya N.
Published: December 2024

Introduction. Synthetic food products, including cultured meat, promise many benefits but require the careful assessment of the safety before mass introduction. The potential health risks associated with the consumption of cultured meat may vary among different populations. Identifying target consumer groups will allow individual risk factors being taken into account and appropriate precautions developing.
The aim of the study was to analyse the hazards of cultured meat and predict the groups of potential consumers for targeted information on adverse effects from its consumption
Materials and methods. A systematic analysis of scientific literature and a sociological study among four hundred twenty three residents of the Perm region (February-August 2023) were conducted. The data were processed using SPSS for Windows 21.0.
Results. Potential hazards in the consumption of cultured meat are related to the presence of chemical contaminants, possible immune system hypersensitivity and changes in the biological value of protein. The study showed that different age groups have varying degrees of vulnerability to these hazards. More than 45% of the respondents are willing to consume cultured meat, especially young people. About 22% of the respondents are willing to include cultured meat in the diet of children, making them the most vulnerable. Willingness to consume cultured meat increases with positive social influence (addressing agricultural, environmental, and biological issues).
Limitations. Only residents of Perm Krai are represented among the respondents who participated in the survey.
Conclusion. The results of the study emphasise the need to inform target groups about the risks associated with cultured meat, taking into account age-specific and individual risk factors. The findings may form the basis for recommendations to ensure the safety of cultured meat before consumption.
Metabolomics analysis of rat blood in atherosclerosis modelling
Authors: Unesikhina Maria S. , Chemezov Aleksei I. , Sutunkova Marina P. , Minigalieva Ilzira A. , Kungurtseva Alexandra K.
Published: December 2024

Introduction. Atherosclerotic changes in blood vessels are one of the main causes of death from cardiovascular diseases worldwide. The use of modern approaches to the study of the disease giving a more detailed description of its pathophysiology may open up additional opportunities for prevention, diagnosis, and treatment. Metabolomics is one of such approaches allows obtaining information on a large number of compounds, the combination of which reflects ongoing metabolic changes. The data presented in this article supplement our previously published study results.
The study aimed to find the relationship between the thickness of the wall of the thoracic aorta in animals on a hyperlipidemic diet and the content of metabolites in the blood.
Materials and methods. The study involved thirty male albino Wistar rats. Atherosclerosis was modelled using a diet consisting of standard feed, simple sugars and fats with the addition of vitamin D3 and Thiamazole. Liquid chromatography with tandem mass spectrometry was used for the metabolomics blood test. Histological sections of rat thoracic aortas were stained with hematoxylin and eosin for the analysis.
Results. Histopathological examination of the thoracic aorta in the animals fed with the atherogenic diet revealed morphological signs of atherosclerosis with severe calcification of the vascular wall. The wall of the thoracic aorta in cases (2.61 ± 0.05 µm) was statistically thicker than in the controls (1.82 ± 0.01 µm) (p < 0.001). Correlation analysis revealed significant negative relationships between thoracic aortic wall thickness and arginine, indole and three of its derivatives, and ketodeoxycholic acid, and positive relationships with glutamate, ophthalmic acid, adenosine diphosphate, two long-chain acylcarnitines, glycocholic acid, oxidized fatty acid, and six lysoglycerophospholipids.
Limitations. The study included only Wistar rats with a limited number of rodents per group.
Conclusion. The relationship between metabolomic alterations in blood and thickness of the wall of the rat thoracic aorta indicates metabolic restructuring typical for atherosclerosis, resulting from oxidative stress, an ongoing inflammatory response, and lipid metabolism disorders characterized by severe calcification, endothelial dysfunction, and increased thrombosis.
Alimentation-dependent prevalence: regional study
Authors: Bogdanova Olga G. , Maraktaev Zorikto V.
Published: December 2024

Introduction. It is widely known that suboptimal nutrition can trigger the mechanisms of development or progression of alimentary-dependent diseases (ADD).
Aim is to study the trend in alimentary-dependent morbidity in the adult population of the Republic of Buryatia (RB).
Materials and methods. The study was conducted on the basis of morbidity for 2014–2023. The RB population in comparison with the data for the Far Eastern Federal District and the Russian Federation. The assessment of the actual power supply was carried out using software.
Results. Comparison of the average ADD indices for the RB for 2019–2023 compared to 2014–2018 showed an increase by 1.23 times for diseases of the circulatory system and 1.17 times for diseases of the endocrine system. The sigmal deviation method revealed that the ADD prevalence in the RB for 2019–2023 exceeds the regional average level by from 2.1 to 8.5% for thyrotoxicosis, diabetes mellitus, including type II, and obesity, the average federative level from 4.4 to 9.7% for diabetes mellitus, including type II, and thyrotoxicosis. In the diet, there is a deficiency of B vitamins, calcium, magnesium, potassium, and a sodium surplus.
Limitations. The results of the study of ADD among the adult population of the region and the nutritional characteristics in the workers of the industrial center clearly do not prove the causality of the formation of these diseases.
Conclusion. The identified ADD features require the coordinated work of an interdisciplinary team of experts and the entire community focused on optimal nutrition.
Assessment of neurotoxicity of gadolinium nanocomposite
Authors: Novikov Mikhail A. , Titov Evgeny A. , Yakimova Natalia L. , Vokina Vera A. , Pankova Anna A. , Skrynnik Anna S. , Lizarev Aleksander V. , Sosedova Larisa M.
Published: December 2024

Introduction. A promising area of nanotoxicology is the study of the effects of gadolinium nanoparticles on a living organism, which will allow achieving high image contrast when performing MRI with a significantly smaller amount of the injected substance. This is possible using high-molecular compounds, for example, arabinogalactan of Siberian larch, which has a stabilizing effect for nanoparticles.
Materials and methods. Experimental studies were performed on ninety six mongrel white male rats weighing 180–240 g, divided into 3 groups (one control and two experimental). A water-based solution was used as the exposed substance, which included gadolinium nanoparticles, as well as a nanostabilizing matrix – the natural polysaccharide arabinogalactan. The solution was administered orally for 10 days in two doses – 500 and 5000 mcg of gadolinium per 1 kg of animal body weight. After the introduction, some of the animals were withdrawn from the experiment and made up the early examination period, the remaining part of the animals were left to survive for 6 months and made up the long-term examination period, and subsequently were also withdrawn from the experiment.
The work used a set of studies aimed at determining neurotoxicity – the “Open Field” test, EEG examination, morphological and morphometric methods.
Results. The structural and functional features of the effect of gadolinium nanocomposite on the central nervous system were expressed in an increase in the number of degeneratively altered neurons when administered a solution at a dose of 500 mcg of gadolinium per 1 kg of animal body weight in the early period of examination, while indices reflecting approximate research activity, behaviour and EEG indices, compared with the control, did not changed.
Limitations. When studying the effects of gadolinium nanoparticles encapsulated in the polysaccharide arabinogalactan on 96 outbred male rats, which is sufficient to use a set of methods to determine the functional state of the central nervous system and structural changes in nervous tissue.
Conclusion. Thus, the subacute effect of gadolinium nanoparticles encapsulated in the arabinogalactan matrix causes structural changes in the nervous tissue, while functional changes in the central nervous system were not observed.
Инновационное развитие системы управления предприятием в условиях цифровой трансформации
Authors: Пальмов С.В. , Мкртчян М.С. , Сагдеева Л.Ф.
Published: December 2024

В статье рассматриваются особенности инновационного развития системы управления предприятием в условиях цифровой трансформации современной экономики. Современные тенденции цифровой трансформации существенно влияют на систему управления предприятием, требуя ее инновационного развития. Переход к цифровой экономике характеризуется внедрением передовых технологий, оптимизацией бизнес-процессов, изменением организационных структур и методов принятия управленческих решений. В этих условиях возникает необходимость совершенствования системы управления предприятием, ориентированной на повышение эффективности, гибкости и адаптивности к динамично меняющимся внешним условиям.

Contemporary trends in digital transformation significantly impact enterprise management systems, necessitating their innovative development. The shift toward a digital economy is marked by the integration of advanced technologies, optimization of business processes, and changes in organizational structures and decision-making methods. Under these circumstances, there is a growing need to enhance enterprise management systems to improve efficiency, flexibility, and adaptability to rapidly changing external conditions. This article explores the characteristics of innovative development in enterprise management systems within the context of the digital transformation of the modern economy.
Финансовый анализ в процессах аудита результатов деятельности организаций: развитие методики
Authors: Чернова С.А.
Published: December 2024

Вопросы эффективного управления связаны с оптимальным взаимодействием управленческих функций, среди которых анализ и аудит, так как, в конечном счете, цель у этих функций одна – повышение эффективности организации в целом и степени доверия партнеров. Какой же функционал отводится каждой из них и где границы и водораздел аудита и анализа? Или, напротив, поле их взаимодействия и сотрудничества? Ответы на вопросы представлены в статье. Кроме того, апробирована методика финансового анализа важнейших результатов деятельности АО «Газпром газораспределение Махачкала».

The issues of effective management are related to the optimal interaction of management functions, including analysis and audit, since, ultimately, these functions have one goal – to increase the efficiency of the organization as a whole and the degree of trust of partners. What functionality is assigned to each of them and where are the boundaries and watershed of audit and analysis? Or, on the contrary, the field of their interaction and cooperation? The answers to the questions are presented in the article. In addition, the methodology for financial analysis of the most important results of the activities of Gazprom Gazoraspredelenie Makhachkala JSC has been tested
Utilization Patterns of Antimicrobials at a Tertiary Care Hospital’s Intensive Care Unit
Authors: Chowdhury MJ
Published: December 2024

Introduction: Antimicrobials are readily prescribed to seriously ill patients, accounting for a large portionof the drugs administered in intensive care units (ICU). Objective: Aimed to explore the antibiotic usagepatterns in the ICU patients of a tertiary care hospital, Sylhet MAG Osmani Medical College Hospital.Methods: A hospital-based retrospective observational study was conducted to explore the pattern of usageof antibiotics in the ICU of Sylhet MAG Osmani Medical College Hospital. The medical records of 530patients admitted to the ICU from July 2020 to June 2021 were reviewed. Results: Antibiotic treatmentwas given to 94.0% of the ICU patients. A culture sensitivity test was done in 72.1% of patients; bloodsamples were more frequently cultured (42.0%). 412 (95.2%) of the 433 samples showed a positive cultureresult. Klebsiella made up 33.3% of the isolated organism. The mean amount of antimicrobials given perpatient was 2.5±1.4. Cephalosporin (38.8%), Carbapenem (31.3%), and Penicillin (29.0%) were the mostcommonly given antimicrobial groups. About half of the patients (50.8%) received multiple antibiotics.The most frequently used drug combinations were Ceftriaxone and Metronidazole, which were given to48.0% of the patients. Conclusion: Cephalosporin and Carbapenem were most frequently utilized asantibacterial agents in this ICU. However, due to the rise of resistance, physicians should be moreaware of using these drugs.
Лингвосемиотический анализ при переводе текстов
Authors: Хушвактова Гулноза
Published: December 2024

В статье рассматривается роль лингвосемиотического анализа в процессе перевода текстов. Лингвосемиотика, как междисциплинарное направление, объединяет лингвистику и семиотику для изучения знаковых систем и их использования в языке и коммуникации. Особое внимание уделено основным концепциям лингвосемиотики, включая понятия знака, кода, контекста, интерпретации и значения. Автор подчеркивает важность лингвосемиотического анализа для обеспечения точности и адекватности перевода, что помогает избежать буквального перевода и сохранить культурные и стилистические особенности исходного текста. Примеры успешного применения лингвосемиотического анализа в переводе метафор, идиом и культурно значимых текстов иллюстрируют его практическую значимость. Также обсуждаются вызовы, с которыми сталкиваются переводчики при использовании этого подхода, и предлагаются решения для их преодоления. В заключении подчеркивается, что лингвосемиотический анализ является важным инструментом для повышения качества переводов.
A Pharmacokinetic/Toxicodynamic Model of Cisplatin Nephrotoxicity Using the Kidney Injury Molecule-1 Biomarker
Authors:   Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical  Sciences, University of Colorado Anschutz Medical Campus, USA, E. Thompson Lauren , Ghimire Avisek ,   Cancer Center, University of Colorado Anschutz Medical Campus, USA
Published: December 2024

Cisplatin is a platinum-based chemotherapeutic that causes acute kidney injury in over of patients.
Male Partner Attendance in Antenatal Care and Associated Factors in Asmara, Eritrea: A Cross-Sectional Study
Authors: Tekle Milkiyas Goytom , Saleh Munir , Yemane Belul , Tesfamariam Yosan , Sium Aklilu
Published: December 2024

Introduction: Male attendance during antenatal care is promoted to be an important intervention to increase positive maternal health outcomes. This is because the attendance of men in antenatal care can play a vital role in ensuring safe pregnancy and skilled delivery. Despite efforts to stimulate male attendance during antenatal care, not many men accompany their wife’s to skilled ANC.

Objective: The aim of this study was to assess male partner attendance to skilled antenatal care and associated factors in Asmara ,Eritrea.
Method: Community based cross-sectional study was conducted on male partners whose women gave birth within 48 months prior to the survey. Multi stage cluster sampling method was used to get the total sample size of 402 participants. A pre-tested and structured questionnaire was used to collect data. Data entry and analysis was done through SPSS version 22.0 .
Result: 52% of male partners attended at least one to antenatal care visit. Respondents who knew about pregnancy danger sign(COR:2.029;99%CI;(1.346-3.058)),who attended ANC education(AOR:2.650;99%CI;(1.643-4.272) ),those who discussed about ANC with their spouse (AOR:2.246;99%CI;(1.205-4.185) )were positively associated with male attendance to antenatal care. The most common reasons for not attending ANC were being preoccupied with other jobs and neglecting its importance.

Conclusion: nearly half of the men did not attend to antenatal care. In order to improve male attendance to antenatal care, health education aimed at increasing men awareness about antenatal care services should be instituted by government bodies.