bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Contract Management Practices on Organizational Performance of Rwanda Development Board (2017-2022)
Authors: Ruhuka Ines , Dushimimana Jean De Dieu
Published: May 2024

The general objective of this research project was to assess the effect of contract management on organizational performance. The following were specific objectives of the study: to analyze the effect of contract planning on performance of Rwanda Development Board, find out the effect of contract negotiation on performance of Rwanda Development Board, assess the effect of contract implementation on performance of Rwanda Development Board and assess the effect of contract monitoring on performance of Rwanda Development Board. To achieve these objectives, literature was reviewed on the subject matter, and then data was collected from 156 employees of RDB and they were chosen by using census sampling technique. Questionnaire, observation, interview guide and documentation were used as tools of data collection. Data was analyzed by using both quantitative data and qualitative data by presenting the findings of respondents through the mean and standard deviation. Findings indicated that there is positive link between contract management and organizational performance whereas it was found that the effect of all contract management on organizational performance will be 1.462 percent; a unit increase in the use of contract planning would lead to an increase in RDB's performance by 19.2%; a one percent increase in the use of contract implementation would lead to an increase in RDB's performance by 3.8%; a one percent increase in the use of contract monitoring would lead to an increase in RDB's performance by 11.5%; and lastly, a one percent increase in the use of contract monitoring would lead to a 35% increase in RDB’s performance. Overall, contract monitoring had the greatest effect on RDB’s performance, followed by contract implementation, while contract planning took third place, and lastly, contract negotiation. At a 5% level of significance and a 95% level of confidence, contract planning varies at a 0.010 level of significance; contract negotiation had a 0.048 level of significance; contract implementation had a 0.031 level of significance; and contract monitoring had a 0.029 level of significance. All the variables were significant (p<0.05). The study also concludes that the main objective of contract management is to ensure that the borrower's contractors, suppliers, or consultants meet agreed project specifications and completion dates.
Understanding the impact of COVID-19 Outbreak on Primary School-aged Children in Sindh: A Contextual Analysis of Post-Pandemic Education
Authors: Abdul Razaque Channa  , Maham Ali  , Shuja Ahmed Mahesar
Published: May 2024

COVID-19 has changed the way we lived, worked and learnt. It has adversely impacted everyone, especially the most vulnerable groups: people with disabilities, senior citizens and children. The negative effects on children's health, socio-psychological development, and intellectual advancement are regarded to be unprecedented in recent human history. This paper examines the educational system of Hyderabad, a city in Sindh, Pakistan during COVID-19 and it investigates the negative effects on children and their school learning. This study is interdisciplinary, focusing on Applied Anthropology and Education policy and pedagogy. Mixed methods both qualitative as well as quantitative are used to collect and analyse the data. For qualitative data collection, ethnographic research methods such as participant observation, semi-structured interviews and case study are used. Surveys through digital sources such as email, WhatsApp, Facebook and SMS are implied to collect quantitative data. Ethnographic fieldwork was conducted in a Government Primary School (GPS), Hyderabad, Pakistan. The findings of the study reveal that post COVID-19 has impacted the school learning and experience of educational attainment in multiple ways to the primary school aged going children. Moreover, it has also revealed the uneven socio-economic opportunities for learning, and discloses the government's inability to reach out to the most vulnerable class of the society in the time of emergency.
O USO DO RAIO-X E DA TOMOGRAFIA COMPUTADORIZADA PARA AVALIAÇÃO DO PROGNÓSTICO DE PACIENTES COM COVID-19
Authors: Reis Eduarda Santos de Assis , Lacerda Fernanda Orlandi , Silva Iasmin Vitória Marques da , Requeijo Márcio José Rosa
Published: May 2024

Esse artigo buscou avaliar o uso da radiografia e da tomografia computadorizada (TC) no diagnóstico e prognóstico de pacientes com COVID-19. Para isso foi realizada uma revisão narrativa por meio de buscas nos bancos de dados Pubmed e Medical Literature Analysis and Retrievel System Online (Medline), a pesquisa foi realizada com os descritores Covid-19, Radiografia e Diagnóstico, foram selecionados artigos publicados nos anos 2020 a 2024 e que estivessem de acordo com o tema do artigo. Radiografia e tomografia computadorizada (TC) são exames de imagem importantes na avaliação de pacientes com COVID-19, especialmente para determinar a gravidade da doença e o prognóstico. A radiografia de tórax pode mostrar opacidades pulmonares características, que são comuns em pacientes com COVID-19. No entanto, a sensibilidade deste exame pode ser limitada em casos leves ou precoces da doença. Por outro lado, a  TC de tórax é mais sensível na detecção de alterações pulmonares associadas ao coronavírus, podendo ajudar a avaliar a extensão e a gravidade das lesões pulmonares, fornecendo informações importantes para o prognóstico do paciente. Portanto, a combinação de exames sorológicos, exames laboratoriais, radiografia e a tomografia computadorizada é uma estratégia eficaz para a identificação do diagnóstico, manejo, prognóstico e morbidade de pacientes com COVID-19.
ANÁLISE DA LEGISLAÇÃO PREVIDENCIÁRIA: DESAFIOS E ESTRATÉGIAS PARA INCLUSÃO DE GRUPOS VULNERÁVEIS NO BRASIL
Authors: Souza Jennyfer Milena da Silva de , Barbosa Jonatha Nogueira , Pinto Matheus Sensine da Costa , Araújo Neuzeli Aparecida Rezende Arnaud
Published: May 2024

Esta pesquisa científica tem por objetivo esclarecer as consequências das falhas e desafios do sistema previdenciário brasileiro na inclusão de grupos vulneráveis, como pessoas com deficiência, idosos e trabalhadores informais. A análise será focada na legislação previdenciária, especialmente a Lei nº 8.212/1991, avaliando sua eficácia na promoção da justiça social e na redução das desigualdades. A metodologia utilizada será bibliográfica, combinando a revisão de literatura acadêmica com a análise documental das normativas previdenciárias. Serão consideradas as contribuições de diversos autores que tratam sobre este tema, buscando entender como a legislação atual impacta o acesso aos benefícios previdenciários e quais medidas podem ser implementadas para tornar o sistema mais inclusivo e eficiente. Além disso, a pesquisa analisará as políticas públicas existentes e a implementação prática dessas normativas, identificando as principais falhas e propondo soluções para aprimorar a proteção social dos grupos mais vulneráveis. Ao final da pesquisa, concluiu-se que, embora a legislação previdenciária atual apresente diversas falhas que dificultam o acesso de grupos vulneráveis aos seus direitos, há estratégias e medidas possíveis para melhorar a eficiência e inclusão no sistema previdenciário brasileiro
Determining the ultraviolet radiation dose experienced by aerosols using ultraviolet-sensitive dyes
Authors: Fu Qingqing , Kruis Frank Einar
Published: May 2024

Abstract. ​​​​​​​The application of ultraviolet (UV)-light-based air disinfection methods holds promise but also presents several challenges. Among these, the quantitative determination of the required UV radiation dose for aerosols is particularly significant. This study explores the possibility of determining the UV dose experienced by aerosols without the use of virus-containing aerosols, circumventing associated laboratory safety issues. To achieve this, we developed a model system comprised of UV-sensitive dyes dissolved in di-ethyl-hexyl-sebacate (DEHS), which facilitates the generation of non-evaporating and UV-degradable aerosols. For the selection of UV-sensitive dyes, 20 dyes were tested, and 2 of them were selected as being the most suitable, according to several selection criteria. Dye-laden aerosol droplets were generated using a commercial aerosol generator and subsequently exposed to UV-C radiation in a laboratory-built UV irradiation chamber. We designed a low-pressure impactor to collect the aerosols pre- and post-UV exposure. Dye degradation, as a result of UV light exposure, was then analyzed by assessing the concentration changes in the collected dye solutions using a UV-visible spectrophotometer. Our findings revealed that a UV dose of 245 mW s cm−2 resulted in a 10 % degradation, while a lower dose of 21.6 mW s cm−2 produced a 5 % degradation. In conclusion, our study demonstrates the feasibility of using aerosol droplets containing UV-sensitive dyes to determine the UV radiation dose experienced by an aerosol.
Subglacial deformation and till formation in a stratigraphic complex Late Pleistocene sequence (Einödgraben/Aurach, Kitzbühel Alps, Austria)
Authors: Reitner Jürgen M. , Menzies John
Published: May 2024

Abstract. Knowledge of subglacial conditions is of great relevance in understanding glacier dynamics. A combination of micro- and macrosedimentological analysis of diamictons and deformation structures can form the basis for the reconstruction of past subglacial conditions. We present the results of such a study on subglacial tills, within an Alpine environment, at Einödgraben in the Kitzbühel Alps (Tyrol, Austria). The Late Pleistocene succession there (MIS 5d–MIS 2) shows great diversity in facies from alluvial and glaciolacustrine deposits to subglacial deposits. Two glaciogenic diamictons (tills) within the sequence were analysed at the microscale and are correlated to the Last Glacial Maximum (LGM; Würmian Pleniglacial) and the early Lateglacial phase of ice decay. The first deformation phase of pre-LGM deposits most likely occurred in a subglacial setting close to the advancing glacier margin and resulted in diapir-like glaciotectonic macrostructures, which are unique to an inner-alpine area. Subglacial erosion over these structures occurred, and later pre-LGM-emplaced deposits underwent deformation and partial homogenisation immediately beneath the glacier base, leading to diamictons, indicative of subglacial deformable bed conditions. The tills of the LGM and the Würmian Lateglacial show a range of microfacies and deformation structures that are evidence of close and rapid changes in till rheology and the stress field dynamic in the subglacial environment. Our study demonstrates the need for a reinvestigation of deposits occurring in the proximity of past active ice interfaces. The paleoglaciological evidence assembled from the detailed and spatially close research on the microsedimentology of tills at Einödgraben reflects our increasing comprehension and understanding of till microsedimentology in Alpine environments. An awareness is also shown of the need for much further research on the glacial depositional mechanics in mountainous terrains that are different from those in the immense lowland plains of the extensive paleo-ice sheets of North America and northern Europe.
A brief history of solid inclusion piezobarometry
Authors: Angel Ross J. , Alvaro Matteo , Ferrero Silvio
Published: May 2024

Abstract. Solid inclusion piezobarometry is the determination of the entrapment conditions of solid inclusions in a host by measurement and interpretation of the residual pressure of the inclusion. The development over the past two centuries of the concepts, analytical tools and measurement techniques of inclusion piezobarometry is reviewed, and potential future developments are outlined for the special issue of the European Journal of Mineralogy devoted to the study of mineral and melt inclusions.
Accelerating Lagrangian transport simulations on graphics processing units: performance optimizations of Massive-Parallel Trajectory Calculations (MPTRAC) v2.6
Authors: Hoffmann Lars , Haghighi Mood Kaveh , Herten Andreas , Hrywniak Markus , Kraus Jiri , Clemens Jan , Liu Mingzhao
Published: May 2024

Abstract. Lagrangian particle dispersion models are indispensable tools for the study of atmospheric transport processes. However, Lagrangian transport simulations can become numerically expensive when large numbers of air parcels are involved. To accelerate these simulations, we made considerable efforts to port the Massive-Parallel Trajectory Calculations (MPTRAC) model to graphics processing units (GPUs). Here we discuss performance optimizations of the major bottleneck of the GPU code of MPTRAC, the advection kernel. Timeline, roofline, and memory analyses of the baseline GPU code revealed that the application is memory-bound, and performance suffers from near-random memory access patterns. By changing the data structure of the horizontal wind and vertical velocity fields of the global meteorological data driving the simulations from structure of arrays (SoAs) to array of structures (AoSs) and by introducing a sorting method for better memory alignment of the particle data, performance was greatly improved. We evaluated the performance on NVIDIA A100 GPUs of the Jülich Wizard for European Leadership Science (JUWELS) Booster module at the Jülich Supercomputing Center, Germany. For our largest test case, transport simulations with 108 particles driven by the European Centre for Medium-Range Weather Forecasts (ECMWF) ERA5 reanalysis, we found that the runtime for the full set of physics computations was reduced by 75 %, including a reduction of 85 % for the advection kernel. In addition to demonstrating the benefits of code optimization for GPUs, we show that the runtime of central processing unit (CPU-)only simulations is also improved. For our largest test case, we found a runtime reduction of 34 % for the physics computations, including a reduction of 65 % for the advection kernel. The code optimizations discussed here bring the MPTRAC model closer to applications on upcoming exascale high-performance computing systems and will also be of interest for optimizing the performance of other models using particle methods.
Mapping the vertical heterogeneity of Greenland's firn from 2011–2019 using airborne radar and laser altimetry
Authors: Rutishauser Anja , Scanlan Kirk M. , Vandecrux Baptiste , Karlsson Nanna B. , Jullien Nicolas , Ahlstrøm Andreas P. , Fausto Robert S. , How Penelope
Published: May 2024

Abstract. The firn layer on the Greenland Ice Sheet (GrIS) plays a crucial role in buffering surface meltwater runoff, which is constrained by the available firn pore space and impermeable ice layers that limit deeper meltwater percolation. Understanding these firn properties is essential for predicting current and future meltwater runoff and its contribution to global sea-level rise. While very-high-frequency (VHF) radars have been extensively used for surveying the GrIS, their lower bandwidth restricts direct firn stratigraphy extraction. In this study, we use concurrent VHF airborne radar and laser altimetry data collected as part of Operation IceBridge over the 2011–2019 period to investigate our hypothesis that vertical heterogeneities in firn (i.e. ice layers) cause vertical offsets in the radar surface reflection (dz). Our results, corroborated by modelling and firn core analyses, show that a dz larger than 1 m is strongly related to the vertical heterogeneity of a firn profile and effectively delineates between vertically homogeneous and vertically heterogeneous firn profiles over a depth range of ∼ 4 m. Temporal variations in dz align with climatic events and reveal an expansion of heterogeneous firn between 2011–2013 covering an area of ∼ 350 815 km2, followed by firn replenishment over the years 2014–2019 spanning an area of ∼ 667 725 km2. Our approach reveals the firn evolution of key regions on the Greenland Ice Sheet, providing valuable insights for detecting potential alterations in meltwater runoff patterns.
Estimating the uncertainty of sea-ice area and sea-ice extent from satellite retrievals
Authors: Wernecke Andreas , Notz Dirk , Kern Stefan , Lavergne Thomas
Published: May 2024

Abstract. The net Arctic sea-ice area (SIA) can be estimated from the sea-ice concentration (SIC) by passive microwave measurements from satellites. To be a truly useful metric, for example of the sensitivity of the Arctic sea-ice cover to global warming, we need, however, reliable estimates of its uncertainty. Here we retrieve this uncertainty by taking into account the spatial and temporal error correlations of the underlying local sea-ice concentration products. As 1 example year, we find that in 2015 the average observational uncertainties of the SIA are 306 000 km2 for daily estimates, 275 000 km2 for weekly estimates, and 164 000 km2 for monthly estimates. The sea-ice extent (SIE) uncertainty for that year is slightly smaller, with 296 000 km2 for daily estimates, 261 000 km2 for weekly estimates, and 156 000 km2 for monthly estimates. These daily uncertainties correspond to about 7 % of the 2015 sea-ice minimum and are about half of the spread in estimated SIA and SIE from different passive microwave SIC products. This shows that random SIC errors play a role in SIA uncertainties comparable to inter-SIC-product biases. We further show that the September SIA, which is traditionally the month with the least amount of Arctic sea ice, declined by 105 000±9000 km2 a−1 for the period from 2002 to 2017. This is the first estimate of a SIA trend with an explicit representation of temporal error correlations.
Effect of Gang Width and Operating Speed on Specific Draft and Weeding Efficiency of Weeding Sweep in Vertisols
Authors: S.N. Yadav  , M.M. Pandey  , D.C. Saraswat
Published: May 2024

The study was conducted at 12%, 15%, 18% and 21% soil moisture in the clayey soil having 52.30 % clay, 11.21 % silt, 13.15 % coarse sand. The penetration resistance was kept reasonably uniform which ranges from 11.980 to 12.178 N/cm2• The four gang widths i.e. 225 mm, 250 mm, 275 mm and 300 mm were taken for the study. The test was conducted at four speeds of operation i.e. 0.28 m s·', 0.42 m s·I, 0.56 m s·1 and 0.70 m s· '. Hundred pins were randomly inserted in to the soil on the path of the tool in 350 mm band to represent the weed in the row. The draft was recorded by transducer designed for the present study. The undisturbed pins were counted to calculate the weeding efficiency. The effect of gang width on specific draft and weeding efficiency was observed to be significant and was linear. Specific draft was lowest for 300 mm gang width at 0.28 m s· , speed and weeding efficiency was higher for 300 mm gang width at 0.42 m S·I speed. It was observed that the relationship between speed and specific draft was linear and that of speed and weeding efficiency was quadratic.
Patrimonio cultural recreado desde las provincias andinas. Oportunidades del turismo literario para Colombia
Authors: Pérez Pinzón Luis Rubén , Johana Rugeles Paez Marian
Published: May 2024

La literatura regional que da identidad cultural y diferenciación patrimonial a las ciudades intermedias en Colombia es reconocida y resignificada por el turismo literario. El objetivo del artículo de reflexión es caracterizar las oportunidades y limitaciones del turismo literario como producto turístico alternativo por medio de rutas provinciales. La metodología cualitativa estuvo mediada por el análisis de contenidos, a partir de una selección de 135 obras literarias que conllevaron a la selección de la obras de tres autores representativos para el diseño de rutas literarias. La conclusión reitera las oportunidades de la literatura vivencial para el turismo cultural provincial al entrelazarse los lugares más representativos del patrimonio territorial con recorridos en los espacios vitales de los autores o sus personajes.
Producción del paisaje patrimonial: relaciones epistemológicas para el análisis de los espacios de la actividad turística
Authors: Gómez Maury Oscar David , González-Quiroz Pilar Andrea
Published: May 2024

El presente artículo busca realizar un abordaje conceptual del paisaje patrimonial desde sus formas de producción material y científica, cuyo alcance sea aplicado al estudio de los espacios de la actividad turística. El procedimiento metodológico se basa en el análisis documental de fuentes asociadas a artículos académicos, manuales sobre intervención paisajística, declaraciones internacionales, libros de autores por relevancia, entre otros.  Con ello se puede determinar que a través de un proceso de hiperespecialización del conocimiento científico con clasificación epistemológica, el fenómeno paisajístico y su producción (conceptual y material) se entrelaza con las dimensiones del espacio geográfico asociadas a región, ambiente, territorio y lugar, las cuales se les otorgan valores socialmente reconocidos a sus objetos, sujetos y acciones, obteniendo precisamente estatus patrimonial. Así, se propone la identificación de tres posibilidades analíticas donde el turismo responde a la producción de espacio y objetos puestos en valor patrimonial a través del paisaje.
Pengaruh Online Customer Review, Rating dan Deskripsi Terhadap Minat Beli Kamar Sanctoo Suites & Villas Pada TripAdvisor
Authors: Adyatma Prastha , Adinda Clearesta
Published: May 2024

Penelitian ini bertujuan untuk menginvestigasi pengaruh Online Customer Review, Rating, dan Deskripsi terhadap minat beli kamar Sanctoo Suites & Villas di platform TripAdvisor. Metodologi yang digunakan adalah kuantitatif dengan menyebarkan kuesioner kepada pengguna TripAdvisor yang berkaitan dengan Sanctoo Suites & Villas. Hasil penelitian menunjukkan bahwa, yang mempengaruhi minat beli dengan signifikan adalah deskripsi. Dalam analisis data, ditemukan bahwa informasi yang disampaikan melalui deskripsi memiliki dampak positif yang lebih kuat daripada ulasan pelanggan online dan rating dalam mempengaruhi minat beli calon tamu. Deskripsi yang informatif dan menarik membantu calon tamu dalam membentuk pemahaman yang lebih baik tentang pengalaman yang mereka harapkan saat menginap di Sanctoo Suites & Villas. Hasil ini memberikan panduan berharga bagi Sanctoo Suites & Villas dalam mengoptimalkan deskripsi mereka untuk meningkatkan daya tarik dan konversi pemesanan. Penelitian ini memberikan wawasan penting tentang pentingnya informasi deskripsi dalam pengambilan keputusan konsumen di era digital, khususnya dalam industri perhotelan. Implikasi praktis dari temuan ini adalah bahwa Sanctoo Suites & Villas perlu fokus pada peningkatan kualitas deskripsi mereka untuk menarik minat beli yang lebih besar dari calon tamu di platform TripAdvisor.
Cauchy integral on time scales: constructive sense
Authors: Sekhose Vikuozonuo , Bharali Hemen
Published: May 2024

We study the Cauchy Delta (resp. Nabla) Integral and the Cauchy α-Integral on time scales in a constructive sense, and state and proof the Cauchy Criteria of Integrability using these definitions and also establish a few results
Lie right ideals and homoderivations in 3-Prime Near-Ring
Authors: Boua Abdelkarim , Golbasi Oznur , Mouhssine Samir
Published: May 2024

In this article, we study the structure of a near-rings N involving a homoderivations satisfying certain constraints on a nonzero Lie right ideal of near-rings
Targeting DNA Methylation Rewires Drug Responses of RB1-Deficient and Neuroendocrine Prostate Cancer
Authors:   Laboratory of Molecular Oncology, Frontiers Science Center for Disease-related Molecular Network, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China., Guo Jiawei
Published: May 2024

A commentary on Targeting DNA methylation and B7-H3 in RB1-deficient and neuroendocrine prostate cancer by Yasutaka Yamada, Varadha Balaji Venkadakrishnan, Kei Mizuno, Martin Bakht, Sheng-Yu Ku, Maria Mica Garcia, Himisha Beltran (2023). Sci Transl Med. 15(722): eadf6732. doi: 10.1126/scitranslmed. adf6732.
Antioxidant and Anti-Inflammatory Activity of Fractionated Artemia Urmiana Extract in Human Peripheral Blood Neutrophils System
Authors:   Department of Molecular Medicine and Biochemistry, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran., Deezagi Abdolkhalegh , Shahram Parisa ,   Department of Molecular Medicine and Biochemistry, National Institute of Genetic Engineering and Biotechnology, Tehran, Iran.
Published: May 2024

Marine organisms are great resources for discovering bioactive compounds with new antioxidant properties. The aim of this work was to purify and isolate the protein fractions of Artemia urmiana and to evaluate antioxidant activities of them on human peripheral blood neutrophils response. For these purposes, crude extracts protein was extracted from napulii of A. urmiana and sequentially fractionated by ion exchange. The antioxidant activities of the samples were determined by DPPH free radical scavenging, reducing power ability assays in comparison with ascorbic acid. In the second phase, the human peripheral blood neutrophils (HPBN) were separated and cultured. The cells were treated with increasing concentrations of crude and partially purified fractions for 24 hrs. After that, the pellet and supernatant of treated cells were separately collected and assayed for Nitro Blue Tetrazolium (NBT) reduction, the activity of Super Oxide Dismutase (SOD) and Nitric oxide content. The results showed that the IC50 values of ascorbic acid, crude extracts, partially purified protein fractions(F1-F8) were 150, 126, 141, 295, 299, 114, 164 and 132 µg/ml respectively in the DPPH radical scavenging activity. The reducing power activity at the highest concentration (200 µg/ml) based on the optical density of the sample listed, were 2.8, 1.4, 0.13, 0.14, 0.17, 0.14, 0.13, 0.66, 0.18 and 0.35 respectively. In NBT reduction and production of Nitric oxide, treated cells did not show significant difference between different concentrations of protein extract and untreated control cells. The activity of SOD was increased in presence of 50-100 µg/ml of crud extract and fractions 1, 2, 3, 4 and 5 in comparison to untreated control cells (p<0.05).
Gallbladder volvulus: Putting a spin on acute cholecystitis
Authors:   Department of HPB Surgery, University Hospitals of Leicester, Leicester, United Kingdom., G Dawson , V Shah ,   Department of Radiology, University Hospitals of Leicester, Leicester, United Kingdom., N Bhardwaj ,   Department of Radiology, University Hospitals of Leicester, Leicester, United Kingdom.
Published: May 2024

First reported in 1898, gallbladder volvulus is rare. It occurs when the gallbladder twists on its longitudinal axis greater than 180 degrees, resulting in occlusion of the cystic vessels and duct. Herein, we describe the case of a 73-year old woman who was diagnosed with acalculus gallbladder volvulus, with the aid of computerised tomography. This was managed by urgent laparoscopic cholecystectomy and the patient continues to do well 15 months postoperatively. Although rare, a high index of suspicion of the condition must remain and a low threshold for imaging is needed to prevent the complications of gallbladder necrosis, perforation and biliary peritonitis.
Central retinal vein occlusion with secondary cilioretinal artery occlusion following oral minoxidil use: A case report and literature review
Authors:   Department of Ophthalmology & Visual Sciences, McGill University Health Center, Montreal Québec, Canada., Bamakrid Motaz , Rahman Sidratul ,   Faculty of medicine and health sciences, McGill University, Montreal Quebec, Canada., El-Hadad Christian ,   Department of Ophthalmology & Visual Sciences, McGill University Health Center, Montreal Québec, Canada.
Published: May 2024

Minoxidil, a drug that is widely used for hair loss treatment, is considered a safe medication. While there are minor side-effects such as scalp irritation or systemic effects like tachycardia, it is rarely associated with severe ocular complications. We report a case where a 35-year-old man, taking oral Minoxidil for alopecia, developed Central Retinal Vein Occlusion (CRVO) with Cilioretinal Artery Occlusion (CLRAO), leading to sudden vision loss. After Minoxidil discontinuation, the patient’s vision significantly improved. This incident emphasises the importance of recognizing potential ocular side effects of Minoxidil among healthcare professionals and necessitates further research to understand its comprehensive impact on health.
Cardiac arrest after severe epistaxis
Authors:   Department of Emergency Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece., Gkarmiri Sofia , Zagalioti Sofia-Chrysovalantou ,   Department of Emergency Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece., Apostolopoulou Aikaterini ,   Department of Emergency Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece., Tzanidakis Georgios ,   Department of Emergency Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece., Nano Adamantia ,   Department of Emergency Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece., Fortounis Konstantinos ,   Surgical Department, Papageorgiou General Hospital of Thessaloniki, Thessaloniki, Greece. University Department of Anesthesia & Intensive Care, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece., Grosomanidis Vasileios ,   Department of Emergency Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece., Fyntanidou Barbara ,   Department of Emergency Medicine, AHEPA University Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
Published: May 2024

Nasal bleeding frequently leads to admissions to the Emergency Department (ED), with anterior nasal packing being a common treatment approach. Our patient was transferred to the ED from a nursing home due to epistaxis, which was already initially managed by nasal packing. Upon arrival at the ED he suffered Cardiopulmonary Arrest (CA) with an initial CA rhythm of Pulseless Electrical Activity (PEA). Advanced Life Support (ALS) was initiated immediately according to the ERC guidelines. Upon intubation, a nasal gauze was aspirated from the endotracheal tube, and approximately ten minutes later, Return of Spontaneous Circulation (ROSC) was achieved. Subsequently, the patient was transferred to the Intensive Care Unit (ICU). Unfortunately, despite medical intervention, the patient succumbed to complications days later. The dislodgement of nasal packing leading to asphyxiation represents a rare but potentially fatal complication of this procedure. Healthcare providers should be vigilant and prepared to promptly address such complications as they arise.
Unravelling the Viral Dynamics: Exploring the Spread of Content in the Digital Landscape
Authors: Khursheed Alam,
Published: May 2024

The advent of social media platforms in the digital age has catalyzed the emergence of 'viral communication' - the rapid dissemination of social issues, real-life events, and narratives through shared videos, messages, and news across digital channels. This phenomenon thrives on internet sharing via social networks, video-sharing websites, email, and messaging apps. Viral videos and messages have become potent tools for individuals and groups to shed light on lesser-known societal aspects. The past two years have witnessed an influx of viral content ranging from thought-provoking videos addressing real-life issues to entertaining and captivating content. This study explores the dynamics of viral content propagation, examining factors contributing to the widespread dissemination of specific videos, messages, and narratives in the digital realm. By analyzing underlying viral communication mechanisms and patterns, the research aims to provide insights into the interplay between content, user engagement, and digital platforms, enhancing the understanding of this increasingly influential phenomenon.
DOI: https://doi.org/10.52783/tjjpt.v45.i02.6392
How – and How Much? An Analysis of Major Conflict Lines Regarding the Transformation of German Animal Farming
Authors: Von Gall Philipp , Luy Jörg , Köder Moritz , Von Meyer-Höfer Marie
Published: May 2024

Based on the concept of a 'future workshop', this paper contributes to the understanding of major conflict lines and future pathways for animal farming in Germany. Participants in the future workshop were tasked with outlining their ideal vision of the future of animal farming, focusing on both its mode and quantity. We found three different types of visions differing in their motivation, farming methods, and the scale of envisioned animal farming: ‘Higher Standards’ (V1), ‘System Change and Reduction’ (V2), ‘Alternatives to Animal Farming’ (V3). V1 seeks to secure the quantities of supply and demand of animal products in Germany with minor adjustments towards improved animal welfare and investments in resource-efficiency and climate friendliness. V2 advocates for comprehensive social and environmental systemic changes throughout the agri-food sector, with substantially fewer animals involved. V3 aims to replace animal farming, with plant-based and other alternatives, whenever and wherever possible. Our findings suggest that there is little ground for a societal consensus on a single future mode and scale of animal farming. Stakeholder dialogues and policy initiatives should therefore allow for different pathways while focusing on compromises in the near future. Short-term solutions may be acceptable to supporters of all three visions, however, achieving this requires reframing the debate from ‘securing the future of animal farming’ to ‘guiding the future of animal farming’, acknowledging the potential – albeit partly – replacement of animal farming by suitable alternatives.
TEKNIK KOMUNIKASI PRAMUWISATA LOKAL DALAM PROSES INTERPRETASI DESA WISATA HIJAU BILEBANTE
Authors: Zahira Athiya Ramadhani  , Jumraidin Jumraidin , H. Lalu Ratmaja
Published: May 2024

This study aims to determine the communication techniques used by local tour guides in the Bilebante Green Tourism Village in the process of interpretation or storytelling to tourists. The method used is a qualitative method by conducting observations, interviews and documentation to several local tour guides in the Bilebante Green Tourism Village. The results of this study are that some tour guides communicate according to standards by self-taught and some have applied Onong Uchjana Effendy's communication techniques which include informative, persuasive, interaction / coercive and human relations communication techniques. Which in doing a communication is also very related to the elements of communication techniques, from Harold Laswell including; who (who / source), says what (what / message), in which channel (media), to whom (who / recipient), with what effect (impact / effect). So that some local guides in the Bilebante Green Tourism Village who have applied appropriate communication techniques have succeeded in attracting tourists to come back with the same personThis study aims to determine the communication techniques used by local tour guides in the Bilebante Green Tourism Village in the process of interpretation or storytelling to tourists. The method used is a qualitative method by conducting observations, interviews and documentation to several local tour guides in the Bilebante Green Tourism Village. The results of this study are that some tour guides communicate according to standards by self-taught and some have applied Onong Uchjana Effendy's communication techniques which include informative, persuasive, interaction / coercive and human relations communication techniques. Which in doing a communication is also very related to the elements of communication techniques, from Harold Laswell including; who (who / source), says what (what / message), in which channel (media), to whom (who / recipient), with what effect (impact / effect). So that some local guides in the Bilebante Green Tourism Village who have applied appropriate communication techniques have succeeded in attracting tourists to come back with the same person
Educação a distância e ensino de psicologia: impasses e possibilidades na perspectiva de psicólogas(os) e estudantes
Authors: Jacinto Pablo Mateus dos Santos , Reis Ana Lúcia Pellegrini Pessoa dos
Published: May 2024

A pesquisa buscou compreender as relações entre a educação a distância e a formação em psicologia, sob a perspectiva de estudantes de psicologia e psicólogas(os) baianas. Realizou-se um levantamento através de um questionário semiestruturado online, no qual foram contemplados os seguintes tópicos: a) Inserção da EaD na graduação em psicologia; b) Percepções sobre EaD na graduação em Psicologia; c) EaD e diretrizes curriculares da Psicologia. Identificou-se que os participantes apresentam baixo aproveitamento e pouco desenvolvimento de habilidades fundamentais para a atuação. Conclui-se que é necessário adaptação dos recursos pedagógicos e metodologias adotados na modalidade EaD a fim de garantir maior aproveitamento do conteúdo.
Legal and Political Policy in Preventing of Money Politics: Case Study and Recommendations
Authors: Siddiq Achmad , Hariyanto
Published: May 2024

Money politics has damaged the democratic system throughout the nation; handling the problem of money politics is not enough to be charged to law enforcement and all elements of society. The seriousness of the government and political parties in tackling the problem of money politics can be done by legal and political means. The results of this study show that political policies in preventing money politics in the 2019 elections in Banyumas Regency where political parties have made several efforts in at least three ways: 1) implementing pacta integrity and providing debriefing to cadres and legislative candidates. 2) All parties tend to follow only the existing rules, especially those issued by the KPU and Bawaslu. 3) It turns out that all parties do not require this, relating to the competency requirements of legislative candidates that are more stringent, intellectual, managerial skills, experience, and morality. Legal policies in the prevention and handling of money politics have carried out prevention strategies through legal policies, namely prevention at the level of legislation policy and judicial policy. In contrast, the execution policy has yet to be well realized.
Early high fat diet exposure changes body composition, biochemical parameters and redox balance in Wistar male rats
Authors: Abreu Giovanna Menezes , Barros Bianca Freitas de Barros , Teles Cyntia Gomes , Almeida Carolina de Oliveira Ramos Petra de , Nascimento Bruna Almeida , Teodoro Anderson Junger , Figueiredo Mariana Sarto
Published: May 2024

Obesity is a public health problem and one of the epidemiologically growing non-communicable chronic diseases. The aim of study was to evaluate the effects of early exposure high fat diet male rats on body composition, bone parameters and serum biochemical and redox balance. Wistar male rats at 30 days old were divided into 2 groups:  1) Control group: received commercial diet and filtered water ad libitum (C, n=20); and 2) High fat group: received a high fat diet and filtered water ad libitum (HF, n=20) until post-natal day 120 (PN120). At PN90 was analyzed body composition. At PN120 were analyzed food intake, body composition, biochemical parameters, bone parameters and serum redox balance. Early high fat diet exposure was able to induce obesity in rats and increase adiposity with lower lean mass, and lead to negative effects on serum biochemical parameters and redox balance, accompanied with changes in femur bone parameters. Thus, exposureWistar male rats after weaning to a high fat diet using lard as the main source of fat, mimicking Western diet, can lead to metabolic and body composition changes in adulthood, which cause obesity and increase the risk to develop non-communicable diseases.
Integration of mathematics in the pedagogy licensure: analysis of the course at IFTO Porto Nacional
Authors: Filho Albano Dias Pereira , Oliveira Cynthia Souza , Sousa Lilissanne Marcelly de Sousa , Patrício Paulo Cesar de Sousa , Balduino Angelo Ricardo
Published: May 2024

The methodology employed in this study followed a qualitative approach, as per Gil's (2017) guidelines, using descriptive and interpretative analysis. The Pedagogical Project of the Pedagogy Degree Program (PPC) of the Porto Nacional Campus, the National Common Curricular Base (BNCC), and Resolution CNE/CP No. 1 of May 15, 2006, were examined. The research aimed to understand and contextualize the curricular guidelines of the course in light of the educational policies established by the BNCC and Resolution CNE/CP No. 1/2006. Detailed readings and comparative analyses of the documents were conducted to identify points of convergence and divergence. The analysis of the results highlighted that the Pedagogy Degree Program at the Porto Nacional Campus - IFTO provides comprehensive training aligned with national curricular guidelines. Graduates are prepared theoretically and practically to work in various professional contexts, including teaching Mathematics, demonstrating ethical commitment and an understanding of students' needs. The course's Fundamentals and Methodologies of Mathematics Teaching discipline addresses the necessary content and methods for effective Mathematics teaching in the early years of Elementary Education, following BNCC guidelines. The course promotes students' engagement and commitment to their professional development, reflecting in the effectiveness of graduates' training.
Neuroergonomics approach in the workplace aiming to standardize movements and increase workers' sense of well-being
Authors: Antônio de Moura Roque , Regina de Oliveira Márcia , Goussain Blaha Gregory Correia Santos , Silva Messias Borges
Published: May 2024

This research focused on the neuroergonomic interactions and investigated the need to standardize activities and program workforce movements to avoid wasting caused by blind or unprogrammed movements. The methodology adopted included related publications and the neuroergonomics bench construction. As a result, a leaner manufacturing process was observed. The assembly process before the intervention was contaminated with excessive movements, waste during assembly and complaints of physical-mental efforts by workers. It is concluded that, after implementing a bench with neuroergonomic principles at the workstation, there was a reduction in assembly and movement time. A implementation of homoscedastic process made easier to control the risks inherent to the production rhythm. Intangibly, it improved workers' perception of well-being. Tangibly, the time to produce the sets was reduced up to 36 minutes daily per production shift.
Prevalence of burnout syndrome in hospital health professionals and associated factors
Authors: Ferreira Juliana da Rosa , Bonow Clarice , Cezar-Vaz Marta Regina , Duro Suele Manjourany Silva , Oliveira Gabriela Laudares Albuquerque de , Heck Rita Maria , Dilélio Alitéia Santiago
Published: May 2024

The hospital environment presents unique challenges compared to other healthcare sectors, such as caring for patients in delicate conditions, long work hours, shift work, and multiple professional commitments. These characteristics can compromise the quality of life of workers and increase the risk of developing Burnout Syndrome. This study aims to examine the prevalence of Burnout Syndrome among healthcare professionals working in a hospital environment, as well as to identify associated factors. A cross-sectional study was conducted with a sample of 209 professionals. Participants completed a self-administered questionnaire containing sociodemographic and occupational information, as well as the Maslach Burnout Inventory-Human Services Survey. The prevalence of Burnout Syndrome was 28.7% (n=60). Professionals with incomes up to R$5000.00 and those in their first job showed a higher likelihood of experiencing this disorder. These findings suggest a moderate prevalence of Burnout Syndrome and underscore the importance of remuneration in valuing workers, as well as the potential association between inexperience and difficulty in coping with the demands of healthcare work.
Relevant MicroRNAs of MMPs and TIMPs with Certain Gut Microbiota Could Be Involved in the Invasiveness and Metastasis of Malignant Tumors
Authors: Nakashima Moeka , Suga Naoko , Ikeda Yuka , Yoshikawa Sayuri , Matsuda Satoru
Published: May 2024

Malignant tumors are heterogeneous diseases characterized by uncontrolled cell proliferation, invasion, and/or metastasis. In particular, cancer stem cells within these tumors might be responsible for the invasiveness and the property of recurrence of malignancies. It has been reported that matrix metalloproteases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) could contribute to the development of tumor invasiveness. Remarkably, specific MMPs can drive the malignant phenotype of tumors counting the acquisition of stem cell feature, in which STATs signaling might play an important role. Furthermore, MMPs might be crucial for extra-cellular matrix remodeling in the pathological condition of cancer stem cells. Some immune responses against cancer stem cells in the connection to MMPs and/or TIMPs have been revealed, which might be an important issue in the treatment of aggressive cancers. MicroRNAs (miRNAs) have emerged as favorable biomarkers owing to their important roles in gene regulation and/or stability. Differential expression patterns of specific miRNA may be associated with different types of tumor. In addition, miRNAs can be detected in various body fluids, proposing easily available specimens for diagnostic purposes in tumor microenvironment. Remarkably, it has been shown that miRNA expression might be also related with the gut microbiota composition. Early detection and accurate monitoring of tumors are critical for effective treatment and/or improved patient outcomes. A better understanding of this mechanism of epigenetics could be of use to bring about innovative tactics for the treatment of malignant tumors.
Protection by L-arginine against Epinephrine-induced Arrhythmia and Cardiotoxicity
Authors: M.E. Abdel-Salam Omar , Baset Marawan Abd El , Omara Enayat A , A. Sleem Amany
Published: May 2024

Nitric oxide is important in control of coronary blood flow, cardiomyocyte contractility, cardiac rhythm, and thrombogenicity. We aimed to investigate the effect of the nitric oxide precursor L-arginine on cardiac arrhythmia and myocardial injury induced by epinephrine in male Sprague-Dawley rats. The possible modulation of L-arginine effects by methylene blue (MethyB), a nitric oxide synthase inhibitor was also examined. Cardiac arrhythmia was induced with 10μg/kg epinephrine given intravenously (i.v.). L-arginine (200mg/kg) or L-arginine and MethyB (100mg/kg) were intraperitoneally (i.p.) administered prior to i.v. epinephrine. Other groups received i.p. saline, only L-arginine or only MethyB (100mg/kg). Results showed that compared with the saline control, epinephrine caused a significant bradycardia (188.7±24.4 vs. 405.6±1.19beats/min), increased QRS duration (0.039±0.006 vs. 0.0185±0.0001s), decreased R wave amplitude (0.18±0.01 vs. 0.23±0.011mv), and ventricular extrasystoles. L-arginine alone showed no significant effect on heart rate (380.8±10.0 vs. 405.6±1.19beats/min) but increased QRS duration (0.029±0.0002 vs. 0.0185±0.0001s), and R wave amplitude (0.47±0.01 vs. 0.23±0.011mv). L-arginine given prior to epinephrine prevented bradycardia, shortened the duration of arrhythmia and decreased the number of extrasystoles. The administration of L-arginine and MethyB almost completely suppressed epinephrine-induced ventricular arrhythmias. Epinephrine caused severe degeneration of muscle fibres, widening of intercellular spaces, cellular infiltrations and interstitial haemorrhage. L-arginine markedly attenuated, while L-arginine/MethyB completely prevented these changes. It is concluded that L-arginine protects against cardiac arrhythmias and cardiac tissue damage caused by epinephrine.