bluuebunny/crossref_metadata_2025 huggingface dataset:
Changes in biomarkers of endothelial function in the blood after intracerebral hemorrhage in rats with type 2 diabetes mellitus
Authors: Lievykh А. E. , Tkachenko V. A. , Kharchenko Y. V. , Shevtsova A. I. , Ushakova G. A. , Zhyliuk V. I.
Published: January 2022

Clinical evidence suggests that type 2 diabetes mellitus can increase the risk of intracerebral hemorrhage and provocation of neurodegeneration. This study was aimed at evaluating biomarkers of glycemic control, lipid profile, oxidative modification of proteins, as well as the functional state of endothelium in Wistar rats with type 2 diabetes mellitus complicated by intracerebral hemorrhage. Experimental type 2 diabetes mellitus was induced by intraperitoneal injection of streptozotocin (65 mg/kg) and nicotinamide (230 mg/kg). The intracerebral hemorrhage was induced by microinjection of sterile saline containing 0.2 IU bacterial collagenase into the striatum. Assessed biomarkers included the area under glycemic curve, glycated hemoglobin, total cholesterol, triglyceride, high-density lipoprotein, advanced glycation end products, markers of oxidative modification of proteins – aldehyde- and ketonephenylhydrazones, and markers of endothelial dysfunction – homocysteine, endothelin-1, von Willebrand factor and asymmetric dimethylarginine in blood serum. Both rats with type 2 diabetes mellitus and rats with intracerebral hemorrhage and diabetes had a significant elevated glycemic control as compared to intact animals. But combined pathology was additionally characterized by an impairment of lipid profile (increased triglyceride level and decreased as total cholesterol and high-density lipoprotein) resulting in a rise in the atherogenic index of plasma. A significant increase in the content of the markers of oxidative modification of proteins was observed in both experimental groups. But the rats with intracerebral hemorrhage and diabetes only had higher levels of advanced glycation end products in comparison with intact animals. The highest levels of endothelin-1, as a biomarker of endothelial dysfunction, were observed in animals with intracerebral hemorrhage and diabetes. Homocysteine and von Willebrand factor were elevated in rats with type 2 diabetes mellitus, while acute intracerebral hemorrhage did not potentiate the further growth in its levels. Such effect was not accompanied by a marked increase of asymmetric dimethylarginine level in blood serum, although there was a clear trend. In conclusion, the development of intracerebral hemorrhage in rats with type 2 diabetes mellitus can intensify the manifestations of oxidative stress, worsen lipid profile, and aggravate endothelial dysfunction. In this case, the pathological process may have the character of a “vicious circle”.
Morphological and physiological-biochemical variability of spore-forming bacteria isolated from the agrocoenosis of winter wheat
Authors: Honchar A. , Tonkha O. , Patyka N. , Lykholat Y. , Patyka T.
Published: January 2022

From an agrocoenosis of winter wheat (Triticum aestivum L.; phylloplane and rhizosphere of the root system; typical chernozem, soil column measuring up to 40 cm), using the classical microbiological methods, we had isolated soil bacteria and characterized them according to the morphological features as representatives of Gram-positive and spore-forming bacteria of Bacillus sp. genus. In the earing-swelling phase of grain, the screening studies found non-pigmented forms of colonies of bacterial isolates, 19 of which were classified to colonial-morphological diversity of R-type with the diameter of 7 to 13 mm. The analysis of physiological condition of cells of populations of soil isolates revealed technologic specificity according to parameters of spore formation in different conditions and incubation time (up to 48–72 h). We observed 90.0% of free spores in axenic cultures as early as after 72 h of cultivation and no more than 10.0% of prospores in the studied monoisolates with stable morphologic traits. Isolates Н10 and Н45 demonstrated the ability to grow in higher cultivation temperatures (+37…+40 °С). According to environmental рН, isolates were able to grow in рН ranging 4.5–8.0. Differential diagnostic testing revealed that as the source of carbon, with formation of acid, soil isolates used arabinose, xylose, mannitol, glucose, galactose, fructose, maltose, sorbitol, glycerin, dextrin, starch, rhamnose and dulcite (with development of alkaline). There was observed active use of mineral forms of nitrogen: ammonium salt and nitrates, aminoacids and proteins. The isolates hydrolyzed casein, gelatin, starch, and litmus was being reduced in the young during growth in milk with litmus. They also exerted catalase activity and were oxidase-positive. Biochemical testing using API test system determined that the studied isolated bacteria differed by a range of fermentation carbohydrates, reduction of nitrates. In the conditions of submerged fermentation, isolates Н38 and Н40 grew in heightened temperature ranges of cultivation (40 °С) for 48 h (according to fact of spore development). Therefore, according to the key morphologic and biochemical traits, strains Н3, Н10, Н13, Н36, Н38, Н40, Н43, Н45 were similar to such of reference strain B. subtilis 8A, and were identified to Bacillus sp., species B. subtilis.
The effect of water-soluble pristine C60 fullerene on 6-OHDA-induced Parkinson’s disease in rats
Authors: Stetska V. O. , Dovbynchuk T. V. , Makedon Y. S. , Dziubenko N. V.
Published: January 2022

Oxidative stress is thought to be one of the mechanisms that leads to the dysfunction and degeneration of dopaminergic neurons in Parkinson’s disease pathogenesis and presumed to be underway during the prodromal phase. Therefore, therapy, which is effective against pre-motor symptoms, might be effective in preventing or delaying the development and progression of Parkinson’s disease. The aim of our study was to investigate the therapeutic efficiency of pristine C60 fullerene aqueous solution (C60FAS) during Parkinson’s disease in rats. The unilateral dopamine deficiency was induced in male Wistar rats (220–250 g) by stereotaxic microinjection of neurotoxin 6-hydroxydopamine (6-OHDA, 12 μg). C60FAS was injected to rats intraperitoneally daily for 10 days (0.65 mg/kg per day). The percentage of destroyed dopaminergic neurons was determined by the apomorphine test and by IHC staining of tyrosine hydroxylase-positive neurons in substantia nigra. We evaluated the rat body weight, the water and food intake, Open Field behavioural test, the level of biochemical antioxidant system, the activity of peritoneal macrophages. Levels of spontaneous and carbachol-stimulated colon motility were estimated by ballonographic method in vivo. C60FAS showed a positive tendency to increase the number of tyrosine hydroxylase-positive cells in the midbrain, which was associated with more profound improvement in apomorphine-rotation behaviour and slight relief of the anxiety level in Open Field test. Furthermore, C60FAS treatment increased the index of stimulated distal colon motor activity while it did not have a significant effect on water content in feces and total gastrointestinal transit time. C60FAS treatment did not affect water intake behaviour or body weight changes while it induced an increase of glutathione level and decrease activity of glutathione peroxidase in the brain as well as an increase in activity of peritoneal macrophages in 6-OHDA-Parkinson’s disease rats. These findings confirmed the potential therapeutic effectiveness of water-soluble pristine C60 fullerene in Parkinson’s disease pathogenesis, though there is ground for caution because of its systemic mild toxic effect.
Pathomorphological changes in the organs of chickens infected spontaneously by the species Salmonella pullorum on private farms in Chernivtsi region
Authors: Shchebentovska O. , Kostynuk A. , Zaika S. , Kovalova L. , Yevtukh L. , Holubtsova M.
Published: January 2022

Commercial poultry production growth and the increase in the number of small farms specializing in raising broiler chickens, laying hens, quails, and other poultry contribute to the spread of infectious diseases. Non-compliance with the principles of biosafety during incubation and breeding results in mass deaths of poultry and, consequently, significant economic losses for farmers. Salmonellosis is one of the most dangerous anthropozoonotic diseases of poultry, which is most often registered in private farms. Age analysis of the poultry salmonellosis in the EU countries indicates the infection of adult laying hens most often, young poultry to a lesser extent, and chickens aged up to 10 days less frequently. Although the program for the prevention and elimination of poultry salmonellosis has been approved at the legislative level in Ukraine, monitoring studies are not carefully conducted. This is especially true for private homesteads and small farms, which greatly complicates the epizootiological situation in some regions of the country. The article describes the pathological and histological changes in the liver, heart, lungs, kidneys, and spleen. The changes were detected in chickens aged 10 and 14 days infected with microorganisms of the species Salmonella pullorum. Eggs for incubation were obtained from different family flocks, and incubation was performed in a single incubator. The initial clinical signs of the disease appeared in chickens aged 7 days and included diarrhea, increased water consumption, lameness, mass concentration of chickens near heat sources, nervous phenomena in the form of circle walking, and partial blindness in some cases. The pathological autopsy revealed hepatomegaly with sharp change in the organ colour, diapedetic hemorrhage under Glisson’s capsule, and diffuse miliary necrosis. Greyish-white nodular lesions of the lungs and heart, dystrophic changes in the kidneys, and deposition of uric acid salts in the ureters were also characteristic features. Diffuse coagulation necrosis, massive perivascular infiltration by heterophilic lymphocytes and stasis were observed in the liver. Changes in the heart were characterized by significant infiltration by mononuclear cells and heterophiles, which led to atrophy, necrosis, and replacement of cardiomyocytes by connective tissue cellular elements. Delymphatization and necrosis of the lymph nodes were pronounced in the spleen.
Specifics of the morphological identification of the pathogen of passaluariasis of rabbits
Authors: Khorolskyi A. , Yevstafieva V. , Kravchenko S. , Pishchalenko M. , Vakulenko Y. , Gutyj B.
Published: January 2022

Passalurus ambiguus (Nematoda, Oxyuroidae) is one of the most common parasites of digestive tract of domestic and wild rabbits and rodents. Passalurus spp. are cosmopolitan, and the mature nematodes are localized in the appendages and large intestine of animals. The passaluariasis infections remain quite relevant in modern rabbit breeding, because the disease is highly contagious, with the possibility of unlimited spread inducing significant economic losses. The aim of the study was to determine the identifying morphological species characteristics of P. ambiguus nematodes, which were isolated from the colon of domestic rabbits (Oryctolagus cuniculus domesticus). The identifying characters of Passalurus include morphological features, namely the presence of a spherical bulb in the esophagus, and the presence of three teeth in the oral capsule. Males of P. ambiguus have a characteristic structure of the tail end, namely the presence of papillary protrusions and a massive narrowed part with a spicule handle, and five papillae around the cloaca. Twenty-eight metric indicators are proposed that characterize the size of the body, oral capsule, esophagus in different parts of it, the tail end, spicules, the location of the cloaca. Two different morphotypes of mature females of P. ambiguus were revealed – short-tailed and long-tailed, which were larger by 19 indicators (by 3.2–43.6%). The morphotypes of P. ambiguus females are characterized; the length of the tail, body length and width in different areas, depth of the oral capsule, esophageal size and its structural elements, the location of the vulva and nerve ring, the width of the caudal process. At the same time, the parameters of esophageal bulb length and caudal process in short-tailed females were higher (by 13.9% and 11.9%, respectively) than in the long-tailed females. A total of 25 morphometric parameters were proposed for the identification of P. ambiguus females. The obtained data indicate the feasibility of further research on the causes of occurrence of such morphotypes in P. ambiguus females and the need to take into account the existence of such forms of females for their differential diagnosis taking into account their proposed morphometric parameters.
Effective Functioning of a Mixed Heterogeneous Team in a Collaborative Robotic System
Authors: Galin Rinat , Shiroky Alexander , Magid Evgeni , Meshcheryakov Roman , Mamchenko Mark
Published: January 2022

The study describes a collaborative robot (cobot) as one of the types of intelligent robotics and its distinctive features compared to other types of robots. The paper presents a collaborative robotic system as a single complex system in which actors of different types – cobots and human workers – perform collaborative actions to achieve a common goal. Elements of a collaborative robotic system, as well as processes and entities that directly influence it are represented. The key principles of Human-Robot Collaboration are described. A collaborative robotic system is analyzed both as a multi-agent system and as a mixed team, whose members are heterogeneous actors.

The relevance of the work lies in a weak level of research on issues of formation of mixed teams of people and cobots and distribution of tasks in such teams, taking into account features of these two types of participants and requirements of their safe collaboration. This work focused on a formation of mixed teams of elements of a single complex human-cobot system, the distribution of tasks among the members of such teams, taking into account the need to minimize costs for its participants and the heterogeneity of the team. As part of the study, the problem of forming a mixed heterogeneous team of people and cobots, and distribution of work among its members, as well as the corresponding mathematical description are presented. Specific cases of the problem, including different cost functions of different types of participants, a limited activity of the team’s members, the dependence of the cost function of the participants of one type on the number of participants of another type, as well as an arbitrary number of works assigned to the team’s members are considered.
Identification of Neural Network Model of Robot to Solve the Optimal Control Problem
Authors: Shmalko Elizaveta , Rumyantsev Yuri , Baynazarov Ruslan , Yamshanov Konstantin
Published: January 2022

To calculate the optimal control, a satisfactory mathematical model of the control object is required. Further, when implementing the calculated controls on a real object, the same model can be used in robot navigation to predict its position and correct sensor data, therefore, it is important that the model adequately reflects the dynamics of the object. Model derivation is often time-consuming and sometimes even impossible using traditional methods. In view of the increasing diversity and extremely complex nature of control objects, including the variety of modern robotic systems, the identification problem is becoming increasingly important, which allows you to build a mathematical model of the control object, having input and output data about the system. The identification of a nonlinear system is of particular interest, since most real systems have nonlinear dynamics. And if earlier the identification of the system model consisted in the selection of the optimal parameters for the selected structure, then the emergence of modern machine learning methods opens up broader prospects and allows you to automate the identification process itself. In this paper, a wheeled robot with a differential drive in the Gazebo simulation environment, which is currently the most popular software package for the development and simulation of robotic systems, is considered as a control object. The mathematical model of the robot is unknown in advance. The main problem is that the existing mathematical models do not correspond to the real dynamics of the robot in the simulator. The paper considers the solution to the problem of identifying a mathematical model of a control object using machine learning technique of the neural networks. A new mixed approach is proposed. It is based on the use of well-known simple models of the object and identification of unaccounted dynamic properties of the object using a neural network based on a training sample. To generate training data, a software package was written that automates the collection process using two ROS nodes. To train the neural network, the PyTorch framework was used and an open source software package was created. Further, the identified object model is used to calculate the optimal control. The results of the computational experiment demonstrate the adequacy and performance of the resulting model. The presented approach based on a combination of a well-known mathematical model and an additional identified neural network model allows using the advantages of the accumulated physical apparatus and increasing its efficiency and accuracy through the use of modern machine learning tools.
An Innovative Approach to Automated Photo-Activation of Crop Acreage Using UAVs to Stimulate Crop Growth
Authors: Sevostyanova Natalya , Lebedev Igor , Lebedeva Valeria , Vatamaniuk Irina
Published: January 2022

Photoactivation of plants by laser treatment is a promising direction in the development of modern agricultural production. Treatment of plants with radiation with specified characteristics stimulates the development of plants, the formation of generative traits and an increase in yield. An approach based on the use of a specialized laser installation mounted on an unmanned aerial vehicle (UAV) is proposed to automate the process of photoactivation of large cultivated areas. It is possible to perform laser activation of large areas with minimal expenditure of time and human resources due to autonomous processing of the field with the help of UAVs. An algorithm for calculating a covering trajectory for covering large rectangular areas with a laser spot with given characteristics is proposed in the paper. A methodology for calculating the required power of the laser installation depending on the altitude and flight time of the UAV is presented. The advantage of the developed approach is its versatility, since this approach takes into account the characteristics of a laser installation and can be used with devices of various types. Depending on the laser parameters, the algorithm builds such a trajectory for the UAV so that the irradiation of plant seedlings is uniform throughout the entire processing process. Field experiments were conducted when the UAV moved along the calculated trajectory at a speed of 0.3 m/s and the average processing time for a field 200 m long and 1 m wide was 9 minutes. The results of field experiments show that laser irradiation on most of the studied crops increased the yield and height of the stand (in cereals - in four out of six crops, in legumes - in four out of five studied crops). The proposed algorithm for constructing a path for uniform laser irradiation of a site takes into account the area of the laser spot to ensure the required radiation characteristics when using any laser installation.
Evaluation of the efficiency of a new pulsatile flow‑generating circulatory-assist system in rotary blood pumps. Research on a mathematical model
Authors: Itkin G. P. , Syrbu A. I. , Kyleshov A. P. , Buchnev A. S. , Drobyshev A. A.
Published: January 2022

Objective: to study the effect of a pulsatile flow-generation (PFG) device on the basic hemodynamic parameters of the circulatory system using a mathematical model.

Results. Modelling and simulation showed that the use of PFG significantly (76%) increases aortic pulse pressure. The proposed mathematical model adequately describes the dynamics of the circulatory system and metabolism (oxygen debt) on physical activity in normal conditions and heart failure, and the use of non-pulsatile and pulsatile circulatory-assist systems. The mathematical model also shows that the use of PFG device blocks the development of rarefaction in the left ventricular cavity associated with a mismatch of blood inflow and outflow in diastolic phase when there is need to increase systemic blood flow by increasing the rotary pump speed.
Modern pancreatic islet encapsulation technologies for the treatment of type 1 diabetes
Authors: Ermakova P. S. , Cherkasova E. I. , Lenshina N. A. , Konev A. N. , Batenkin M. A. , Chesnokov S. A. , Kuchin D. M. , Zagainova E. V. , Zagainov V. E. , Kashina A. V.
Published: January 2022

The review includes the results of analytical research on the problem of application of pancreatic islet encapsulation technologies for compensation of type 1 diabetes. We present a review of modern encapsulation technologies, approaches to encapsulation strategies, insulin replacement technologies: auto-, allo- and xenotransplantation; prospects for cell therapy for insulin-dependent conditions; modern approaches to β-cell encapsulation, possibilities of optimization of encapsulation biomaterials to increase survival of transplanted cells and reduce adverse consequences for the recipient. The main problems that need to be solved for effective transplantation of encapsulated islets of Langerhans are identified and the main strategies for translating the islet encapsulation technology into medical reality are outlined.
Surgical treatment of biatrial myxoma
Authors: Ivanov A. S. , Mozheiko N. P. , Akopov G. A. , Lugovskiy M. K. , Shelest O. O.
Published: January 2022

Cardiac myxoma is a primary tumor histologically formed by multipotent subendocardial mesenchymal cells. Myxomas account for approximately 50% of all cardiac tumors in adults. Myxomas are most commonly located in the left atrium. Very rarely, myxomas can be located in several heart chambers. Only about 100 cases of patients with myxomatous lesions of both atria have been described in the literature. In this paper, we present a successful clinical case of a young patient with biatrial myxomas.
Lung cancer in solid organ transplant recipients
Authors: Nikulin A. V. , Pashkov I. V. , Yakunin Ya. S.
Published: January 2022

Lung cancer remains the leading cause of cancer mortality worldwide. Solid organ transplant recipients are at risk of developing malignant tumors, including lung cancer, due to long-term use of immunosuppressive drugs. Development of cancer, including lung cancer, in this patient cohort, has a number of peculiarities. Moreover, malignant tumors in these patients are difficult to treat and have a poorer prognosis. This review presents a study of the issues concerning the mechanisms of lung cancer development, screening methods and treatment in solid organ transplant recipients.
The incidence and risk factors of chronic rejection in acutely rejected pediatric liver transplantation
Authors: Dehghani S. M. , Shahramian I. , Ayatollahi M. , Parooie F. , Salarzaei M. , Bahmanyar M. , Sargazi A. , Delaramnasab M.
Published: January 2022

Background. Chronic graft rejection (CR) represents an increasing concern in pediatric liver transplantation (LT). Risk factors of CR in this population are uncertain. In present study, we aimed to ascertain if clinical parameters could predict the occurrence of CR in LT children.

Methods. We retrospectively analyzed the results from 47 children who had experienced acute hepatic rejection in Namazee hospital, Shiraz, Iran during 2007–2017.

Results. Out of 47 children, 22 (46.8%) and 25 (53.2%) were boys and girls respectively. Ascites, gastrointestinal bleeding, and spontaneous bacterial peritonitis were observed in 20 (44.4%), 14 (31.1%), and 4 (9.1%) respectively. Posttransplant vascular and biliary complications were observed in 3 (7%) and 4 (9.3%) cases respectively. The mean time from LT to normalization of liver enzymes was 14.2 ± 7.5 days. The mean of acute rejection episodes was 1.4 ± 0.6 (median = 1 (22, 46.8%), range of 1–3). Six (12.7%) patients experienced CR. The mean time from LT to CR was 75 ± 28.4 days. A significant association was found between CR and patients’ condition (being inpatient or outpatient) before surgery (P = 0.03). No significant relationship was found between CR and post-transplant parameters except for biliary complications (P = 0.01). Both biliary complication (RR = 33.7, 95% CI: 2.2–511, P = 0.01) and inpatient status (RR = 10.9, 95% CI: 1.1–102.5, P = 0.03) significantly increased the risk of CR.

Conclusion. Being hospitalized at the time of LT, and development of biliary complications might predict risk factors for development of CR in LT children.
Changes in glomerular filtration rate in liver recipients after reduced exposure to calcineurin inhibitors with concomitant everolimus administration within the first year after immunosuppression conversion
Authors: Syutkin V. E. , Salienko A. A. , Zhuravel S. V. , Novruzbekov M. S.
Published: January 2022

Objective: to compare changes in estimated glomerular filtration rate (eGFR) in liver recipients with initially normal and impaired eGFR within the first year after immunosuppression conversion.

Materials and methods. Enrolled in the study were 215 recipients of deceased-donor livers from February 2009 to February 2020, who received everolimus with dose reduction or complete withdrawal of calcineurin inhibitors (immunosuppression conversion, ISxC) for varying periods of time. GFR was measured using the MDRD-4 formula immediately before ISxC, then 3, 6, and 12 months after orthotopic liver transplantation (LTx). One month was considered an acceptable temporary deviation from the corresponding point.

Results. At the time of ISxC, 32 (15%) of 215 recipients had normal renal function. Chronic kidney disease (CKD) increased in 60% of the recipients with normal eGFR by the end of the first year following ISxC; the fall in eGFR was particularly pronounced in older recipients. In the group with a baseline eGFR of 60–89 mL/min/1.73 m2, eGFR normalized in 62% of cases within 12 months; 28% of cases had no changes in renal function. In the subgroup with a pronounced decrease in eGFR at the time of ISxC, increased eGFR was observed as early as 1 month after ISxC, and the maximum was recorded after 3–6 months. The mean eGFR relative to baseline by month 3 after eGFR were higher for ISxC that was done in the first 2 months after LTx (19.7 ± 15.7 ml/minute/1.73 m2) than for ISxC done in the long-term period after LTx (10.1 ± 8.7 ml/minute/1.73 m2, p < 0.05).

Conclusion. Changes in eGFR in liver recipients receiving EVR plus low-dose calcineurin inhibitor (CNI) depend on baseline eGFR and are multidirectional. The use of ISxC in the early post-LTx period led to a more pronounced improvement in eGFR. Maximal changes in eGFR were observed by 3–6 months after ISxC.
Substantiation of Approaches to the Analysis and Assessment of the Eﬀectiveness of Participants in the Implementation of Diversifcation Programs.
Authors: Pisareva O. M.
Published: January 2022

Purpose: of the article is to substantiate conceptual approaches to the formation of a toolkit for assessing the eﬀectiveness of participants in the development and implementation of diversifcation programs for enterprises of the military-industrial complex in the context of digital transformation of management.

Methods: the research methodology is based on general economic approaches to studying the problems of the efciency of economic activity of economic entities and special approaches to the formation of complex systems for analyzing and assessing the eﬀectiveness and efciency of the activities of project management participants in the process of developing and implementing programs for the diversifcation of the defense industry. The basis of the methodology is the concept of performance management in the context of digital transformation of management.

Results: the article presents the key provisions and the main results of the study, obtained on the basis of studying the materials of scientific publications and open information sources in the subject area under consideration using the methods of logical, content and statistical analysis. Based on the specifcs of diversifcation programs, it is proposed to use the provisions of the performance management concept as a theoretical basis for the formation of a tool for assessing the activities of their participants. An integral multiplicative criterion of efciency for a comprehensive assessment of activities is proposed. It is built on the indicators of fve aspects of assessing the performance of participants in diversifcation programs. These aspects assess the completenes s of the organizational and methodological support of the diversification process, the consolidated eﬀectiveness and efciency of the program activities, the quality of management, as well as the fnancial security of the implementation of the diversifcation program activities.

Conclusions and Relevance: a scenario approach to substantiating the parameters of the incentive mechanism in the model of coordinated activity of the participants in the implementation of the diversifcation program is proposed, which takes into account the assessment of its commercial parameters. The results presented in the article are useful in the development of methodological support for assessing the eﬀectiveness and organizing incentives for participants in diversifcation programs in the context of the formation of a digital ecosystem for managing enterprises of the military-industrial complex.
Assessment of Risks and Threats of "Green" Entrepreneurship based on Cross-Factor Modeling
Authors: Kozhevinа O. V. , Belyaevskaya-Plotnik L. A.
Published: January 2022

The article is a continuation of a number of scientifc studies conducted by the authors within the framework of government assignments and grants, dedicated to identifying the relationship between the economic security of territories and the development of "green" entrepreneurship on them.

Purpose: of the study is to model the assessment of the state of economic security of territories under various conditions of the transition to "green" entrepreneurship, taking into account the action of external and internal factors. "Green" entrepreneurship is a priority area for the development of Russian regions, consistent with the achievement of Russia's national strategic goals for the period up to 2030.

Methods: in this work, cross-factor modeling and the method of integral analysis are used to calculate the composite index of the state of economic security and its structural components, taking into account the development of "green" entrepreneurship, supplemented by the method of a priori ranking of factors to assess the contribution of each component and justify the priority the selected factors aﬀecting the level of economic security of the regions.

Results: a three-component cross-factor model for assessing the state of economic security in certain regions of the Russian Federation (Moscow Region, Leningrad Region, Sverdlovsk Region, Novosibirsk Region, Altai Territory, Krasnodar Territory) had been calculated and tested. The regions were ranked according to the value of each of the components, as well as separately according to the aggregate level of economic security. The necessity of stimulating the development of "green" entrepreneurship in each of the analyzed regions. Have been substantiated and stimulating and discouraging factors that have an impact on the level of economic security, taking into account "green" entrepreneurship, pointwise in each subject, have been identifed.

Conclusions and Relevance: the proposed approach to assessing the impact of the identifed factors on the level of economic security of the regions, taking into account the development of "green" entrepreneurship on the basis of the developed cross-factor model, made it possible to build a rating of territories and identify stimulating and discouraging factors in their development. On the basis of which to determine the tools for inﬂuencing the economic security in a separate entity.
Digital Institutional Transformation of Electronic Trading Platforms in the Field of Public Procurement of the Russian Federation
Authors: Bizhoev B. M.
Published: January 2022

Purpose: the aim of the article is to calculate the reduction in transaction costs when transferring purchases to electronic format, as well as determine the potential for digitizing the consideration of all requirements for procurement participants.

Methods: the study is based on the conceptual provisions of the institutional economic theory, the use of the system approach methodology, the use of survey research methods, and the generalization of expert assessments. The development of the proposed topic is also based on the use of methods of economic and statistical analysis, scientifc abstraction, comparison and scientifc generalizations.

Results: as a result of a detailed analysis, the digital transformation electronic trading platforms into the digital trading platforms was substantiated. The paper also shows the role of electronization and digitalization in reducing transaction costs and time spent on customers. It was revealed that the transfer of authority to the electronic trading platforms not only excludes the possibility of errors, unfair and opportunistic behavior of customers, and as a result – the imposition of fnes, but also reduces the time spent on procurement. The main approaches to improving the contract system, building its digital ecosystem, where the necessary actions are performed by the software and hardware complex, and the contract manager only "accompanies" the purchase, are proposed. The article presents the evolution of the use of digital technologies and the corresponding legal regulation in Russia.

Conclusions and Relevance: the use of digital technologies in public procurement is becoming a factor causing changes in the contractual system. The electronic form of trading has brought a new reality, opportunities for digital transformation are opening up. The use of automated counterparty verifcation technologies in the activities of electronic trading platforms is a potential factor in reducing transaction costs. In the future, it is possible to use digital technology “big data”, which helps to identify and categorize the necessary information regarding the availability of experience in the execution of similar contracts.
Digitalization of the Japanese Economy by the Example of the Banking Sector: Current Results, Prospects and Problems
Authors: Kostyukova K. S.
Published: January 2022

Purpose: the purpose of this study is to examine the current state of Japan's digital transformation, with a focus on the banking sector, analyzing specifc examples, identifying obstacles that hinder the achievement of expected results.

Methods: the article is based on the analysis of scientifc and analytical materials devoted to the problem of research, a set of general scientific methods is applied, including comparison, scientifc generalization, analogy, etc.

Results: the article presents the main trends and current results of digitalization of Japanese banks, provides examples of projects, identifies problematic areas of the implemented policy. A hypothesis is put forward about the key role of the government in the development of new standards for the organization of work, taking into account the use of innovative technologies. For Japan, digitalization is chosen as a key tool to mitigate the current socio-economic situation. Digitalization is already being implemented in the healthcare sector, agriculture, etc. Another sector at the center of digitalization is the fnancial one. Financial technologies form new markets and products. Non-banking companies penetrate into the areas occupied by classical banks, competing and even displacing them.

These processes are observed both in Japan and in other countries of the world, including Russia. Therefore, studying the Japanese experience of integrating digital technologies into the fnancial sector is important. Although Russia is among the leaders in the digitalization of the financial sector, it is difcult for fntech companies to break into the Russian market due to pressure from large classical banks, as well as the lack of trust in fntech companies from the population.

Conclusions and Relevance: in contrast to the manufacturing sector, digitalization of non-manufacturing areas is slower in Japan. This is due to a shortage of qualifed personnel, fnancial risks, etc. Today, the priority for fnancial institutions remains to create the basis for the introduction of digitalization and improve management efciency. From the point of view of ensuring the stability of the fnancial system, it is expected that the Bank of Japan, together with the government, will encourage initiatives in the feld of fnancial development.
The Region of Metlaoui Facing Seismic Hazards: Study and Cartographic Approach (South Atlas of Tunisia)
Authors: Aliouet Slim , Melki Fetheddine
Published: January 2022

The region of Metlaoui (South Atlas of Tunisia) is listed as one of the major seismotectonic zones of the national territory. About 10 major seismic events with moderate magnitude have occurred from the beginning of last century. The event of 7/11/1989 (Ms = 4.4) was undoubtedly the most important. It caused very significant material damage estimated at 224,525,000 Tunisian Dinars. This study uses a mapping tool to define areas with relatively high degrees of hazard and vulnerability. It also seeks to understand the active fault of the seismic events recorded in this region.
The Impact of Income on the Division in Domestic Labor: The Case Study in Rural Vietnam
Authors: Minh Le Phuong Nu
Published: January 2022

The imbalance in the distribution of responsibilities for unpaid work has profoundly affected women’s’ empowerment and full participation in economic and social activities. The study surveyed more than 150 households in one rural area in one Vietnamese province. This study's result in the central rural area did not improve Vietnamese domestic labor division compared to previous studies. The daily time taken up doing housework strongly correlates with gender, and the t-Test is statistically significant differences in the mean by gender. Wives earn additional money, and then spend less time on housework; nonetheless, the wife's minimum threshold for housework time is much higher than her husband's maximum threshold. Unlike the time devoted to housework, how much income contributes to the household does not affect childcare time. Except for the gender factor, the importance and extent of factors affecting housework and childcare differed markedly. Peculiarly, the unemployment of husbands is not a normal situation in Vietnamese families, so the assumption of exchange theory is not satisfied, though the wife is almost unable to negotiate with the unemployed husband.
DNA Barcode for the Parthenogenetic Surinam Cockroach Pycnoscelus surinamensis (Linnaeus, 1758) (Blattodea: Blaberidae) from India
Authors: Shabnam A , Dinesh K P
Published: January 2022

DNA Barcoding is one of the emerging tools in molecular identification of faunal diversity, specifically insect fauna. The Surinam cockroach, Pycnoscelus surinamensis is the only known roach to be obligatorily parthenogenetic, with reported haplotypes. P. surinamensis is well established in Indomalayan, tropical and subtropical regions and substantially documented from India with a phenetic approach. Herewith we report the first set of mt DNA barcode from a vouchered collection for the species from southern Western Ghats India. Discussions are made on the identity of two sequences each of Blatteria species and Pycnoscelus species reported from USA.
The Role of Clinical Guidelines for the Management of Chemotherapy-Induced Nausea and Vomiting in Children with Cancer
Authors: Farhangi Hamid , Ghasemi Ali , Bahari Mojgan , Alirezaei Zohreh , Rabbani Javadi Akram , Badiee Zahra , Nanvabashi Fatemeh
Published: January 2022

Background: Nausea and vomiting are among the most important side-effects associated with chemotherapy in children with cancer, affecting the quality of their lives. Clinical guidelines for selecting antiemetics are effective in reducing acute chemotherapy-induced nausea and vomiting (CINV).
Materials and Methods: The present quasi-experimental study compared the effectiveness of the Pediatric Oncology Group of Ontario (POGO) CINV guideline with that of conventional arbitrary therapies for CINV in 82 children aged 6 months to 16 years old. Out of 177 cycles of chemotherapy, in 101 cycles patients were treated according to POGO-CINV Guideline; in the other 76 cycles, patients were treated with arbitrary types and doses of antiemetics. Then, vomiting in the first 24 hours after chemotherapy in both groups was measured and compared.
Results: In this study, 82 patients hospitalized in the Hematology Department of Dr. Sheikh Children’s Hospital were enrolled, of whom 48 patients (58.7%) were boys and 34 (41.3%) were girls. The mean age of patients was 6.24±4.47 years (6 months to 16 years). The results of the current study showed that using a protocol for the prevention of vomiting based on the patient’s age and the type of chemotherapy is superior to conventional management of CINV. Findings showed that the frequency of nausea and vomiting in the protocol group was significantly reduced in comparison with the control group (p˂0.005). Moreover, a reduction in the frequency of nausea and vomiting was quite significant in the sub-categories of the protocol group who had received high-risk or moderate-risk emetogenic drugs (p˂0.005).
Conclusion: The results of the current study showed that using the POGO guideline, which takes into account the patient’s age and the type of chemotherapy, is more effective than arbitrary management of CINV, particularly in children.
Association of Body mass index and serum ferritin level in pediatrics with Beta-thalassemia major disease
Authors: Yousefian Saeed , Miri Aliabad Ghassem , Saleh Rana , Khedmati Majid
Published: January 2022

Background: Beta-thalassemia major is a type of inherited blood disease that results in variable outcomes such as severe anemia due to haemoglobin chains. Recurrent and lifelong blood transfusions as a treatment in beta-thalassemia major disease lead to iron deposition in various organs and cause the failure of multiple organs. Failure of affected organs leads to Body mass index (BMI) abnormality. This study aimed to evaluate the association between BMI and serum ferritin level as a marker for iron overload.
Materials and Methods: A cross-sectional study designed and conducted with total number of 740 paediatrics, with mean age about 14.2±8.7 years old and with beta-thalassemia major requiring recurrent blood transfusion. Patient information, including demographics, serum ferritin level and percentage of BMI, was recorded and analysed by SPSS 25.0 and the statistical significant level, considered as 0.05.   
Results: A total number of 740 paediatrics with beta-thalassemia major disease (mean age about 14.2±8.7 years) were included to study to examine the association between serum ferritin level and their BMI.  The total mean serum level of ferritin calculated about 3326 ± 3859 Nanogram/mililitter (ng/ml). Totally, 447 (60.4%) case of them had BMI percentile less than 5%, 274 (37.02%), 16 (2.16%) and 3 (0.4%) had BMI percentile 5%-85%, 85%-95% and more than 95%. There was no relation between gender and serum ferritin levels. The relationship between age and BMI has been positive (P=0.002). Finally, it resulted that there was a negative relationship between the BMI percentile and mean serum ferritin levels in paediatrics with beta-thalassemia major (P=0.031).
Conclusion: Frequent Blood transfusion is associated with elevated serum ferritin level in paediatrics with beta-thalassemia major disease and experiencing lower percentiles of BMI in these patients.
Can non-functional adrenal incidentaloma be ranked among cardiovascular risk factors?
Authors: YAĞIZ Burcu , AKALIN Aysen , YORULMAZ Göknur , MACUNLUOĞLU Aslı Ceren , YAĞIZ Onur
Published: January 2022

Objectives: We aimed to evaluate the potential association of a nonfunctional adrenal incidentaloma (NFAI) with cardiovascular risk factors.
Methods: Forty-three patients over the age of 40 found to have NFAI and 28 healthy controls were included in this prospective study. The control group was selected from individuals who were similar in age and gender. Glucose, insulin, c-peptide, lipid profile, erythrocyte sedimentation rate, high sensitivity c-reactive protein, fibrinogen and 25-hydroxy cholecalciferol and carotid artery intima-media thickness (CIMT) were measured in both groups.
Results: Waist circumference, erythrocyte sedimentation rate, triglyceride and CIMT values were found higher in the patient group (p = 0.002, p < 0.001, p = 0.001, p = 0.024, respectively). It was observed that 10 (23.2%) of the patients had no suppression with 1 mg dexamethasone but suppression was provided with 2 mg dexamethasone for 2 days, and all of these patients with ‘possible autonomous cortisol secretion’ had at least one comorbidity. While there was no significant difference between the groups in terms of the presence of comorbidity, a significant difference was found in terms of diabetes mellitus (90% of the patients with autonomous cortisol secretion, 24.2% of those who were suppressed with 1 mg dexamethasone had diabetes mellitus; p < 0.001; Chi-square test).
Conclusions: Higher waist circumference, erythrocyte sedimentation rate, triglyceride and CIMT values in our patients with NFAI and increased diabetes mellitus frequency in patients with autonomous cortisol secretion suggest that NFAI may be one of the cardiovascular risk factors.
Performance Assessment of Soil Moisture Meter under Sandy Clay Loam Soil
Authors: Balaji K. , Pandiarajan T.
Published: January 2022

Background: Irrigation performs a substantial function for the growth of Agricultural vegetation. Soil supplies essential nutrients for the growth of plant and provides anchor support to the roots of the crops. Soil Moisture permits the requirement for water system to be measured ahead of a yield giving indications of misery. Knowing the soil moisture status empowers exceptionally productive water system, giving the water as and when required and wiping out the inefficient utilization of water when water system isn’t required.
Methods: Sandy clay loam soil contains a decent arrangement of plant supplements and supports most sorts of plants and yields. So in the field plentiful accessibility of this soil its texture is discovered by estimating soil moisture.
Result: Within the research we developed a soil moisture meter based on capacitive type sensor the output is analog voltage which is calibrated to soil moisture percentage and its performance is comparatively investigated with different moisture sensor under sandy clay loam soil. The proposed model is highly emphasized on the soil moisture percentage that is the level of water content in the soil. The percentage value is displayed in the LCD. The deployment cost is highly reduced in the proposed model.