bluuebunny/crossref_metadata_2025 huggingface dataset:
The first fossils of the most basal pseudoscorpion family (Arachnida: Pseudoscorpiones: Pseudotyrannochthoniidae): evidence for major biogeographical shifts in the European paleofauna
Authors: Schwarze Daniel , Harms Danilo , Hammel Jörg U. , Kotthoff Ulrich
Published: June 2021

Pseudoscorpions belong to the oldest terrestrial lineages with origins in the Devonian (ca. 385 Ma) but their fossil record is extremely sparse and little is known about their diversification over time. Here, we describe the first fossil species of the pseudoscorpion family Pseudotyrannochthoniidae that resemble the Devonian fossils in major details, such as the chaetotaxy of the pedipalps. We describe two new species, Allochthonius balticus sp. nov. from Baltic amber and Centrochthonius bitterfeldicus sp. nov. from Bitterfeld amber in northern Europe. Both species can unequivocally be assigned to extant genera and provide further evidence for dramatic range shifts in European invertebrate biota since the Paleogene. Allochthonius Chamberlin, 1929 is a diverse genus in eastern Asia (China, Korea, and Japan) today but does not occur anywhere in central Asia, Europe or North America. Centrochthonius Beier, 1931 is a poorly known genus but seems to be restricted to high altitude habitats in central Asia (China, Kyrgyzstan, and Nepal). With range retractions to regions more than 4600 km away from the European amber deposits, the fossils highlight total lineage extinction in Europe and survival in refugia that are climatically and botanically most similar to the Baltic amber forest of the Eocene. Overall, our results support the concept of morphological but potentially also ecological stasis in major pseudoscorpion lineages over long periods of time and agree with previous studies that suggested a warm temperate rather than subtropical or tropical climate for the time of amber deposition.
Using intrinsic vulnerability and anthropogenic impacts to evaluate and compare groundwater risk potential at northwestern and western coastal aquifers of Sri Lanka through coupling DRASTIC and GIS approach
Authors: Phok Ratha , Kosgallana Duwage Wasantha Nandalal , Sumana Bandara Weerakoon , Herath Mudiyanselage Thalapitiye Ge Pitawala , Hingure Arachchilage Dharmagunawardhane
Published: June 2021

Groundwater vulnerability assessment has become a crucial step in successfully protecting groundwater against pollution. An attempt of this study has been made to evaluate groundwater contamination risk using intrinsic vulnerability and land-uses in Vanathavillu, Kalpitiya and Katana area in Sri Lanka, using coupled DRASTIC with GIS as feasible methodology. The findings reveal that the groundwater in the areas under study falls under very low to high contamination risk. The higher risk of contamination has been identified in most of the Kalpitiya (about 82%) with the moderate along the beach in the west and next to Puttalam lagoon in the northeast and southeast. This is mainly due to pollution risk inherent with intense vegetable cultivation, over pumping, shallow groundwater tables and permeable sandy soil. Vanathavillu is under very low to moderate contamination risk, in which the moderate risk (about 13%) has especially been found the center, central southwest and west of the area. The relative less deep groundwater tables, possible seepage from the underlying limestone aquifer and less permeable red earth soil could be cause for the moderate risk in the area. Furthermore, results show that the Katana has low to moderately high groundwater contamination risk. Nitrate has a good agreement with the different pollution risk classes and that nitrate can be used as an indicator of aquifer degradation inherent with land-use activities in the coastal areas. Groundwater quality monitoring network should be set up to minimize the anthropogenic acts, particularly in high and moderate contamination risk zones.
Geologic mapping and basement–sediment contact delineation along Profile X, Igarra–Auchi area, Southern Nigeria using ground magnetic and electromagnetic methods
Authors: Agoha Chidiebere Charles , Mgbeojedo Tochukwu Innocent , Okoro Eze Martins , Akiang Francis Begianpuye , Onwubuariri Chukwuebuka Nnamdi , Al-Naimi Latifa Shaheen
Published: June 2021

Outcrop mapping as well as electromagnetic and ground magnetic surveys was carried out within Auchi and Igarra localities in order to attempt an interpretation of the geology of the areas and to delineate the boundary between basement and sedimentary terrains. Geologic mapping was done by collecting samples of outcrops at five different locations within the areas. Three lithofacies were identified within Auchi area and they are the basal shale unit, tabular cross-bedded sandstone unit and ferruginized sandstone unit. The pebbly shale is greyish black in colour; the cross-bedded sandstone unit is greyish white, coarse-grained at the base and finer at the top with pockets of clay, while the ferruginized sandstone is dark red. Rocks of the Precambrian basement complex underlie Igarra area. The area is underlain by metasediments that have been intruded by igneous rocks. Results show the presence of three major groups of igneous and metamorphic rocks within the area, and they are the migmatite–gneiss complex, metasediments and porphyritic granites. The electromagnetic and ground magnetic data acquired along Profile X located along Auchi–Igarra–Ibillo road were processed using Microsoft Excel Software and the resulting plots delineated areas with lower electrical conductivities and higher magnetic susceptibilities, as well as areas with higher electrical conductivities and lower magnetic susceptibilities. The areas with lower electrical conductivities and higher magnetic susceptibilities are interpreted to be underlain by basement rocks, while the areas with higher electrical conductivities and lower magnetic susceptibilities are underlain by sedimentary rocks. The plots also delineated the most likely basement–sedimentary boundary in the area.
Evaluating the effect of drill string rotation and change in drilling fluid viscosity on hole cleaning
Authors: Olawale Samuel Bright , Longe Promise O. , Ofesi Samuel Felix
Published: June 2021

The most primitive hole challenge is cleaning the hole, which is more severe in deviated wells. This problem was tackled in this research via experimental analysis and graphical evaluations. To hit this aim, rheological parameters were experimentally obtained, and Noah’s model was used to determine cutting bed erosion time at varying heights. A graphical evaluation was done using a case study of deviated wells X and Y from a Niger Delta field. The result shows that low-viscosity fluid, KCL polymer fluid and high-viscosity fluid take 124, 283 and 342 min, respectively, to erode equal height as graphical evaluation shows that hole cleaning will grow complex on deviation. Thus, the deduction from this work in reducing non-productive time (NPT) related to hole cleaning in drilling operation is first, prior to making a trip, pumping low-viscosity fluid at a high flow rate. Secondly, during drilling, increasing drill string rotation in deviated wells can effectively stir the cuttings into the annulus above the low session of the hole.
ALEA – Adaptive eLEArning System – Lernende datenbankbasierte Lernsysteme in der Datenbanklehre
Authors: Schneider Kerstin , Keller Fabian , Habekost Pia , Schmeil Victor , Dampmann Markus , Schorch Florian
Published: June 2021

Im Bereich Datenbanken werden selbstentwickelte E‑Learning-Systeme an vielen Hochschulen seit Jahren erfolgreich verwendet. An der Hochschule Harz werden E‑Learning-Systeme im Bereich Datenbanken im Rahmen der Lehre und für die Lehre entwickelt, weiterentwickelt und eingesetzt. Das Gesamtsystem, welches die zusammengehörenden Systeme umfasst, wird als ALEA bezeichnet. Es werden relevante Komponenten von ALEA erläutert, die im Rahmen der Datenbanklehre für die klassischen Teilgebiete SQL, ER-to-Relational-Mapping und Normalisierung genutzt werden.
Strange Duality Between the Quadrangle Complete Intersection Singularities
Authors: Ebeling Wolfgang , Takahashi Atsushi
Published: June 2021

There is a strange duality between the quadrangle isolated complete intersection singularities discovered by the first author and Wall. We derive this duality from a variation of the Berglund–Hübsch transposition of invertible polynomials introduced in our previous work about the strange duality between hypersurface and complete intersection singularities using matrix factorizations of size two.
Comparing performance on the Months of the Year Backwards test in hospitalised patients with delirium, dementia, and no cognitive impairment: an exploratory study
Authors: Hasemann Wolfgang , Duncan Nikki , Clarke Caoimhe , Nouzova Eva , Süßenbach Lisa-Marie , Keerie Catriona , Assi Valentina , Weir Christopher J. , Evans Jonathan , Walsh Tim , Wilson Elizabeth , Quasim Tara , Middleton Duncan , Weir Alexander J. , Barnett Jennifer H. , Stott David J. , MacLullich Alasdair M. J. , Tieges Zoë
Published: June 2021

Purpose

To investigate performance of the Months of the Year Backwards (MOTYB) test in older hospitalised patients with delirium, dementia, and no cognitive impairment.

Methods

Secondary analysis of data from a case–control study of 149 hospitalised patients aged ≥ 65 years with delirium [with or without dementia (N = 50)], dementia [without delirium (N = 46)], and no cognitive impairment (N = 53). Verbatim transcripts of MOTYB audio recordings were analysed to determine group differences in response patterns.

Results

In the total sample [median age 85y (IQR 80–88), 82% female], patients with delirium were more often unable to recite months backward to November (36/50 = 72%) than patients with dementia (21/46 = 46%; p < 0.01) and both differed significantly from patients without cognitive impairment (2/53 = 4%; p’s < 0.001). 121/149 (81%) of patients were able to engage with the test. Patients with delirium were more often unable to engage with MOTYB (23/50 = 46%; e.g., due to reduced arousal) than patients with dementia (5/46 = 11%; p < 0.001); both groups differed significantly (p’s < 0.001) from patients without cognitive impairment (0/53 = 0%). There was no statistically significant difference between patients with delirium (2/27 = 7%) and patients with dementia (8/41 = 20%) in completing MOTYB to January, but performance in both groups differed (p < 0.001 and p < 0.02, respectively) from patients without cognitive impairment (35/53 = 66%).

Conclusion

Delirium was associated with inability to engage with MOTYB and low rates of completion. In patients able to engage with the test, error-free completion rates were low in delirium and dementia. Recording of engagement and patterns of errors may add useful information to MOTYB scoring.
Cyber—Physical Power System (CPPS): A review on measures and optimization methods of system resilience
Authors: Wu Gongyu , Li Zhaojun S.
Published: June 2021

The Cyber—Physical Power System (CPPS) is one of the most critical infrastructure systems in a country because a stable and secure power supply is a key foundation for national and social development. In recent years, resilience has become a major topic in preventing and mitigating the risks caused by large-scale blackouts of CPPSs. Accordingly, the concept and significance of CPPS resilience are at first explained from the engineering perspective in this study. Then, a review of representative quantitative assessment measures of CPPS resilience applied in the existing literature is provided. On the basis of these assessment measures, the optimization methods of CPPS resilience are reviewed from three perspectives, which are mainly focused on the current research, namely, optimizing the recovery sequence of components, identifying and protecting critical nodes, and enhancing the coupling patterns between physical and cyber networks. The recent advances in modeling methods for cascading failures within the CPPS, which is the theoretical foundation for the resilience assessment and optimization research of CPPSs, are also presented. Lastly, the challenges and future research directions for resilience optimizing of CPPSs are discussed.
Betting on the Wrong (Trojan) Horse: CSR and the Implementation of the UN Guiding Principles on Business and Human Rights
Authors: WETTSTEIN Florian
Published: June 2021

Ten years after the publication of the United Nations Guiding Principles on Business and Human Rights (UNGPs), implementation efforts are in full swing. Companies in particular have used their existing corporate social responsibility (CSR) structures to make sense of and implement Pillar II of the UNGPs. This process has led to a co-optation of the business and human rights (BHR) agenda. One manifestation of such co-optation is the instrumentalization of CSR to confront and undermine the growing trend towards binding BHR legislation. Accordingly, this contribution conceptualizes Pillar II implementation as a process of domestication, co-optation and confrontation of the BHR agenda. It makes sense of this process by juxtaposing it with long-standing critique against CSR put forth particularly by critical management scholars, raising the question whether CSR is indeed well-equipped to drive BHR implementation efforts within companies.
Why the United Nations is Not the Ideal Forum for Business and Human Rights: The UNGPs and the Right to COVID-19 Vaccine Access in the Global South
Authors: SANTORO Michael A.
Published: June 2021

The research and development leading to the discovery and distribution of safe and effective COVID-19 vaccines demonstrated the indispensable nature of the pharmaceutical industry. While governments played an important role in financing these efforts by prepaying for dosages, it was private industry that delivered the scientific and technical miracles. At the same time, because of vaccine nationalism and hoarding, citizens of the global south have inadequate access to vaccines. This is a moral and human rights tragedy for which governments, not the pharmaceutical industry, are primarily responsible. This article argues that, as illustrated by humanitarian disaster of inadequate vaccine access in the global south, the failure of the UNGPs to adequately address the paramount role of government in human rights violations, even when there is shared responsibility with business, is a systemic failure that makes the United Nations an inappropriate forum for addressing business and human rights issues.
Detecting supraglacial debris thickness with GPR under suboptimal conditions
Authors: Giese Alexandra , Arcone Steven , Hawley Robert , Lewis Gabriel , Wagnon Patrick
Published: June 2021

The thickness of a supraglacial layer is critical to the magnitude and time frame of glacier melt. Field-based, short pulse, ground-penetrating radar (GPR) has successfully measured debris thickness during a glacier's melt season, when there is a strong return from the ice–debris interface, but profiling with GPR in the absence of a highly reflective ice interface has not been explored. We investigated the performance of 960 MHz signals over 2 km of transects on Changri Nup Glacier, Nepal, during the post-monsoon. We also performed laboratory experiments to interpret the field data and investigate electromagnetic wave propagation into dry rocky debris. Laboratory tests confirmed wave penetration into the glacier ice and suggest that the ice–debris interface return was missing in field data because of a weak dielectric contrast between solid ice and porous dry debris. We developed a new method to estimate debris thicknesses by applying a statistical approach to volumetric backscatter, and our backscatter-based calculated thickness retrievals gave reasonable agreement with debris depths measured manually in the field (10–40 cm). We conclude that, when melt season profiling is not an option, a remote system near 1 GHz could allow dry debris thickness to be estimated based on volumetric backscatter.
Organizational Learning Under Institutional Complexity: Evidence from Township Clusters in China
Authors: You Shuyang , Zhou Abby Jingzi , Zhou Steven Shijin , Jia Liangding , Wang Chengqi
Published: June 2021

Drawing from conceptualizations of organizational learning and institutional complexity, we advance the understanding of how the coexistence of multiple institutional logics in a community influences firms’ learning. Viewing communities where firms and local governments coexist as clusters, our analysis of 354 firms in 39 township clusters in China shows that government logic negatively moderates the positive effect of community logic on organizational learning; however, social connections between the community and local governments mitigate this negative effect. Modeling the relationship between the two logics in this manner extends prior conceptualizations of interfirm learning as a process of isomorphic diffusion of social norms and advances understanding of the role of institutions in organizational learning. This study also offers new insights for theoretical conversations on the compatibility and incompatibility of multiple institutional logics by demonstrating when logic multiplicity leads to conflicts and when it maintains harmony.
A large ‘discovery’ experiment: Gender Initiative for Excellence (Genie) at Chalmers University of Technology
Authors: Saline Maria , Sheeran Mary , Wittung-Stafshede Pernilla
Published: June 2021

Sweden tops gender equality rankings, but Swedish academia is still lacking women in top positions. To address gender inequality in its faculty, Chalmers University of Technology has invested 300 million SEK (30 million Euros) over 10 years in Gender initiative for Excellence (Genie). Genie aims to increase the university’s success and excellence via gender equality efforts. In this editorial, we want to share insights on explicit efforts during Genie’s first 2.5 years with the goal to inspire and advise other universities and researchers.
Do floral resources affect fitness of adult Cydia pomonella (Linnaeus 1758) (Lepidoptera: Tortricidae)?
Authors: Mátray Silvia , Herz Annette
Published: June 2021

The introduction of flowering plants into orchards can increase functional biodiversity in pome fruit cultivation. Plants provide nectar, pollen and prey resources supporting pollinators and natural enemies. However, pests may also benefit from floral diets and a careful selection of plants is necessary to reduce any risk of pest proliferation. The codling moth Cydia pomonella is a major pest in apple growing worldwide and adults are known to consume sugars. The impact of floral diets (parsnip, wild carrot, coriander, red clover) on longevity, fecundity and fertility of adult codling moth was examined under laboratory conditions. In general, male moths lived longer than females, regardless of dietary treatments. Moths survived longest when supplied with parsnip flowers as a floral diet. Contrary to carrot, coriander resulted in higher longevity of adult C. pomonella compared to moths provided with red clover as a negative control. Adult nutrition on floral diets did not affect fecundity substantially. As expected, the majority of eggs were laid within the first week. Prolongation of moths’ lifespan by floral diets did not significantly increase the total number of eggs laid in contrast to a diet with 25% sucrose solution. According to these results, the risk of inadvertently promoting codling moth when growing selected flowering plants in the orchard will be rather low, because the fitness of the moths and especially the reproduction of the females will not be substantially enhanced.
Developmental trajectories of autistic social traits in the general population
Authors: Pender Richard , Fearon Pasco , St Pourcain Beate , Heron Jon , Mandy Will
Published: June 2021

Background

Autistic people show diverse trajectories of autistic traits over time, a phenomenon labelled ‘chronogeneity’. For example, some show a decrease in symptoms, whilst others experience an intensification of difficulties. Autism spectrum disorder (ASD) is a dimensional condition, representing one end of a trait continuum that extends throughout the population. To date, no studies have investigated chronogeneity across the full range of autistic traits. We investigated the nature and clinical significance of autism trait chronogeneity in a large, general population sample.

Methods

Autistic social/communication traits (ASTs) were measured in the Avon Longitudinal Study of Parents and Children using the Social and Communication Disorders Checklist (SCDC) at ages 7, 10, 13 and 16 (N = 9744). We used Growth Mixture Modelling (GMM) to identify groups defined by their AST trajectories. Measures of ASD diagnosis, sex, IQ and mental health (internalising and externalising) were used to investigate external validity of the derived trajectory groups.

Results

The selected GMM model identified four AST trajectory groups: (i) Persistent High (2.3% of sample), (ii) Persistent Low (83.5%), (iii) Increasing (7.3%) and (iv) Decreasing (6.9%) trajectories. The Increasing group, in which females were a slight majority (53.2%), showed dramatic increases in SCDC scores during adolescence, accompanied by escalating internalising and externalising difficulties. Two-thirds (63.6%) of the Decreasing group were male.

Conclusions

Clinicians should note that for some young people autism-trait-like social difficulties first emerge during adolescence accompanied by problems with mood, anxiety, conduct and attention. A converse, majority-male group shows decreasing social difficulties during adolescence.
SOME
-HARDY AND
-RELLICH TYPE INEQUALITIES WITH REMAINDER TERMS
Authors: JIN YONGYANG , SHEN SHOUFENG
Published: June 2021

In this paper we obtain some improved

$L^p$
-Hardy and

$L^p$
-Rellich inequalities on bounded domains of Riemannian manifolds. For Cartan–Hadamard manifolds we prove the inequalities with sharp constants and with weights being hyperbolic functions of the Riemannian distance.
The validity and reliability of the Turkish version of the Family Inventory of Needs
Authors: Sağlam Zeynep , Koç Zeliha
Published: June 2021

Objective

The aim of this methodological study was to test the validity and reliability of the Turkish version of the Family Inventory of Needs.

Methods

The universe of the study consisted of 300 family members of inpatients hospitalized in the palliative care units of four hospitals in northern Turkey between April 12, 2019 and December 30, 2019. The translation process was performed in multiple stages using the forward–backward translation model. The reliability of the Family Inventory of Needs was evaluated using the Cronbach α reliability coefficient and item-total score correlations. Exploratory factor analyses were applied to examine the factor structure of the scale and its construct validity. To test the time invariance of the scale, the relationships between the scores obtained from the first and second applications were examined using the intraclass correlation coefficient (ICC).

Results

The Kaiser–Meyer–Olkin value of the Family Inventory of Needs was found to be 0.893. The items of the Family Inventory of Needs were found to explain 45.23% of the total variance in scores. The Turkish form of the scale consisted of the importance and fulfillment subdimensions, and had 19 items. The ICCs of the test–retest scores of the importance and fulfillment subdimensions of the Family Inventory of Needs were found to be, respectively, ICC = 1.000 and ICC = 0.730 with a positive, linear, and highly significant relationship between the scores. The item-total score correlation coefficients of the scale were found to vary between 0.920 and 0.908 in the importance subdimension, and between 0.930 and 0.922 in the fulfillment subdimension.

Significance of results

The Turkish version of the Family Inventory of Needs was found to be a valid and reliable measurement tool that can be safely used with the family members of Turkish inpatients.
Mixed Judicial Selection and Constitutional Review: Evidence from Spain
Authors: Garoupa Nuno , Gili Marian , Gómez Pomar Fernando
Published: June 2021

Spanish Constitutional Court – Judicial behaviour – Mixed judicial selection – Empirical testing – Decisions of the Spanish Constitutional Court, 1980-2018 – Judicial background – Government – Senate – Congress – Spanish Judicial Council – Invalidation of statutes –Dissent opinions – Shaping politicisation.
The ‘Person of Northern Ireland’: A Vestigial Form of EU Citizenship?
Authors: Bierbach Jeremy B.
Published: June 2021

Northern Ireland – United Kingdom – Republic of Ireland – Divergent development of Irish and British nationality law – Citizenship of the European Union – Good Friday Agreement – Brexit – Emma DeSouza – Family unity as a source of constitutional conflict – Reverse discrimination – Cross-border equality as a means of representation reinforcement – Richard Plender
Investigating Object Files in Spatial Cueing
Authors: Büsel Christian , Valuch Christian , Bliem Harald R. , Sachse Pierre , Ansorge Ulrich
Published: June 2021

Abstract. In spatial cueing, cues presented at target position (valid condition) can capture visual attention and facilitate responses to the target relative to cues presented away from target position (invalid condition). If cues and targets carry different features, the necessary updating of the object representation from the cue to the target display sometimes counteracts and even reverses facilitation in valid conditions, resulting in an inverted validity effect. Previous studies reached partly divergent conclusions regarding the conditions under which object-file updating occurs, and little is known about the exact nature of the processes involved. Object-file updating has so far been investigated by manipulating cue–target similarities in task-relevant target features, but other features that change between the cue and target displays might also contribute to object-file updating. This study examined the conditions under which object-file updating could counteract validity effects by systematically varying task-relevant (color), response-relevant (identity), and response-irrelevant (orientation) features between cue and target displays. The results illustrate that object-file updating is largely restricted to task-relevant features. In addition, the difficulty of the search task affects the degree to which object-file updating costs interact with spatial cueing.
An Empirical Approach to Identifying Subject Matter Experts for the Development of Situational Judgment Tests
Authors: Zhang Don C. , Wang Yi
Published: June 2021

Abstract. The development of a scoring key for the situational judgment test often requires subject matter experts (SMEs) to identify the best responses for a hypothetical situation. And yet, there is no gold standard for identifying the SMEs. This paper describes an empirical and context-free approach: the Cochran–Weiss–Shanteau (CWS) method, which does not rely on external criteria such as tenure or credential. We first describe the theory behind the empirical approach of expertise. We also outline the CWS method and provide an R script for calculating the CWS index. Next, we demonstrate how the CWS index can be used for improving interrater agreement and the efficiency of SME selection. Finally, we examined the nomological network of the CWS index. We found that the CWS index was associated with reflective thinking and intuition avoidance.
The MLKL kinase-like domain dimerization is an indispensable step of mammalian MLKL activation in necroptosis signaling
Authors: Zhang Yu , Liu Jia , Yu Dandan , Zhu Xinxin , Liu Xiaoyan , Liao Jun , Li Sheng , Wang Huayi
Published: June 2021

MLKL phosphorylation by RIP3 is the commitment step of necroptosis execution, which could induce MLKL activation featured as MLKL monomer-oligomer transition. Here, we reported that the dimerization of the MLKL kinase-like domain was the direct consequence of RIP3 triggered MLKL-phosphorylation. Two inter-dimer interfaces were found in the crystal structure of human MLKL. Mutations destroying both interfaces could prevent RIP3-induced MLKL oligomerization and necroptosis efficiently. Moreover, we confirmed MLKL self-assembly by the internal coiled-coil region is necessary for MLKL oligomerization and function. The mutations disrupting coiled-coil self-assembly repressed necroptosis, but it did not prevent RIP3-induced dimerization of the MLKL kinase-like domain. So that, MLKL activation is a sequential process, which begins with kinase-like domain dimerization, and followed by internal coiled-coil region self-assembly to form a proper MLKL oligomer. Besides human MLKL, structural and functional analysis showed the kinase-like domain dimerization was conserved among mammalian species, suggesting it is a general step of the RIP3-induced MLKL activation process.
Nanophotonic biosensors harnessing van der Waals materials
Authors: Oh Sang-Hyun , Altug Hatice , Jin Xiaojia , Low Tony , Koester Steven J. , Ivanov Aleksandar P. , Edel Joshua B. , Avouris Phaedon , Strano Michael S.
Published: June 2021

Low-dimensional van der Waals (vdW) materials can harness tightly confined polaritonic waves to deliver unique advantages for nanophotonic biosensing. The reduced dimensionality of vdW materials, as in the case of two-dimensional graphene, can greatly enhance plasmonic field confinement, boosting sensitivity and efficiency compared to conventional nanophotonic devices that rely on surface plasmon resonance in metallic films. Furthermore, the reduction of dielectric screening in vdW materials enables electrostatic tunability of different polariton modes, including plasmons, excitons, and phonons. One-dimensional vdW materials, particularly single-walled carbon nanotubes, possess unique form factors with confined excitons to enable single-molecule detection as well as in vivo biosensing. We discuss basic sensing principles based on vdW materials, followed by technological challenges such as surface chemistry, integration, and toxicity. Finally, we highlight progress in harnessing vdW materials to demonstrate new sensing functionalities that are difficult to perform with conventional metal/dielectric sensors.
The widespread and unjust drinking water and clean water crisis in the United States
Authors: Mueller J. Tom , Gasteyer Stephen
Published: June 2021

Many households in the United States face issues of incomplete plumbing and poor water quality. Prior scholarship on this issue has focused on one dimension of water hardship at a time, leaving the full picture incomplete. Here we begin to complete this picture by documenting incomplete plumbing and poor drinking water quality for the entire United States, as well as poor wastewater quality for the 39 states and territories where data is reliable. In doing so, we find evidence of a regionally-clustered, socially unequal household water crisis. Using data from the American Community Survey and the Environmental Protection Agency, we show there are 489,836 households lacking complete plumbing, 1,165 community water systems in Safe Drinking Water Act Serious Violation, and 9,457 Clean Water Act permittees in Significant Noncompliance. Further, elevated levels of water hardship are associated with rurality, poverty, indigeneity, education, and age—representing a nationwide environmental injustice.
Rapid evolution of bacterial mutualism in the plant rhizosphere
Authors: Li Erqin , de Jonge Ronnie , Liu Chen , Jiang Henan , Friman Ville-Petri , Pieterse Corné M. J. , Bakker Peter A. H. M. , Jousset Alexandre
Published: June 2021

While beneficial plant-microbe interactions are common in nature, direct evidence for the evolution of bacterial mutualism is scarce. Here we use experimental evolution to causally show that initially plant-antagonistic Pseudomonas protegens bacteria evolve into mutualists in the rhizosphere of Arabidopsis thaliana within six plant growth cycles (6 months). This evolutionary transition is accompanied with increased mutualist fitness via two mechanisms: (i) improved competitiveness for root exudates and (ii) enhanced tolerance to the plant-secreted antimicrobial scopoletin whose production is regulated by transcription factor MYB72. Crucially, these mutualistic adaptations are coupled with reduced phytotoxicity, enhanced transcription of MYB72 in roots, and a positive effect on plant growth. Genetically, mutualism is associated with diverse mutations in the GacS/GacA two-component regulator system, which confers high fitness benefits only in the presence of plants. Together, our results show that rhizosphere bacteria can rapidly evolve along the parasitism-mutualism continuum at an agriculturally relevant evolutionary timescale.
Commercial afforestation can deliver effective climate change mitigation under multiple decarbonisation pathways
Authors: Forster Eilidh J. , Healey John R. , Dymond Caren , Styles David
Published: June 2021

Afforestation is an important greenhouse gas (GHG) mitigation strategy but the efficacy of commercial forestry is disputed. Here, we calculate the potential GHG mitigation of a UK national planting strategy of 30,000 ha yr−1 from 2020 to 2050, using dynamic life cycle assessment. What-if scenarios vary: conifer-broadleaf composition, harvesting, product breakouts, and decarbonisation of substituted energy and materials, to estimate 100-year GHG mitigation. Here we find forest growth rate is the most important determinant of cumulative mitigation by 2120, irrespective of whether trees are harvested. A national planting strategy of commercial forest could mitigate 1.64 Pg CO2e by 2120 (cumulative), compared with 0.54–1.72 Pg CO2e for planting only conservation forests, depending on species composition. Even after heavy discounting of future product substitution credits based on industrial decarbonisation projections, GHG mitigation from harvested stands typically surpasses unharvested stands. Commercial afforestation can deliver effective GHG mitigation that is robust to future decarbonisation pathways and wood uses.
Evaluating the climate impact of aviation emission scenarios towards the Paris agreement including COVID-19 effects
Authors: Grewe Volker , Gangoli Rao Arvind , Grönstedt Tomas , Xisto Carlos , Linke Florian , Melkert Joris , Middel Jan , Ohlenforst Barbara , Blakey Simon , Christie Simon , Matthes Sigrun , Dahlmann Katrin
Published: June 2021

Aviation is an important contributor to the global economy, satisfying society’s mobility needs. It contributes to climate change through CO2 and non-CO2 effects, including contrail-cirrus and ozone formation. There is currently significant interest in policies, regulations and research aiming to reduce aviation’s climate impact. Here we model the effect of these measures on global warming and perform a bottom-up analysis of potential technical improvements, challenging the assumptions of the targets for the sector with a number of scenarios up to 2100. We show that although the emissions targets for aviation are in line with the overall goals of the Paris Agreement, there is a high likelihood that the climate impact of aviation will not meet these goals. Our assessment includes feasible technological advancements and the availability of sustainable aviation fuels. This conclusion is robust for several COVID-19 recovery scenarios, including changes in travel behaviour.
The role of chalcogen vacancies for atomic defect emission in MoS2
Authors: Mitterreiter Elmar , Schuler Bruno , Micevic Ana , Hernangómez-Pérez Daniel , Barthelmi Katja , Cochrane Katherine A. , Kiemle Jonas , Sigger Florian , Klein Julian , Wong Edward , Barnard Edward S. , Watanabe Kenji , Taniguchi Takashi , Lorke Michael , Jahnke Frank , Finley Johnathan J. , Schwartzberg Adam M. , Qiu Diana Y. , Refaely-Abramson Sivan , Holleitner Alexander W. , Weber-Bargioni Alexander , Kastl Christoph
Published: June 2021

For two-dimensional (2D) layered semiconductors, control over atomic defects and understanding of their electronic and optical functionality represent major challenges towards developing a mature semiconductor technology using such materials. Here, we correlate generation, optical spectroscopy, atomic resolution imaging, and ab initio theory of chalcogen vacancies in monolayer MoS2. Chalcogen vacancies are selectively generated by in-vacuo annealing, but also focused ion beam exposure. The defect generation rate, atomic imaging and the optical signatures support this claim. We discriminate the narrow linewidth photoluminescence signatures of vacancies, resulting predominantly from localized defect orbitals, from broad luminescence features in the same spectral range, resulting from adsorbates. Vacancies can be patterned with a precision below 10 nm by ion beams, show single photon emission, and open the possibility for advanced defect engineering of 2D semiconductors at the ultimate scale.
Direct activation of the proton channel by albumin leads to human sperm capacitation and sustained release of inflammatory mediators by neutrophils
Authors: Zhao Ruiming , Dai Hui , Arias Rodolfo J. , De Blas Gerardo A. , Orta Gerardo , Pavarotti Martín A. , Shen Rong , Perozo Eduardo , Mayorga Luis S. , Darszon Alberto , Goldstein Steve A. N.
Published: June 2021

Human voltage-gated proton channels (hHv1) extrude protons from cells to compensate for charge and osmotic imbalances due metabolism, normalizing intracellular pH and regulating protein function. Human albumin (Alb), present at various levels throughout the body, regulates oncotic pressure and transports ligands. Here, we report Alb is required to activate hHv1 in sperm and neutrophils. Dose-response studies reveal the concentration of Alb in semen is too low to activate hHv1 in sperm whereas the higher level in uterine fluid yields proton efflux, allowing capacitation, the acrosomal reaction, and oocyte fertilization. Likewise, Alb activation of hHv1 in neutrophils is required to sustain production and release of reactive oxygen species during the immune respiratory burst. One Alb binds to both voltage sensor domains (VSDs) in hHv1, enhancing open probability and increasing proton current. A computational model of the Alb-hHv1 complex, validated by experiments, identifies two sites in Alb domain II that interact with the VSDs, suggesting an electrostatic gating modification mechanism favoring the active “up” sensor conformation. This report shows how sperm are triggered to fertilize, resolving how hHv1 opens at negative membrane potentials in sperm, and describes a role for Alb in physiology that will operate in the many tissues expressing hHv1.
Unexpected contribution of fibroblasts to muscle lineage as a mechanism for limb muscle patterning
Authors: Esteves de Lima Joana , Blavet Cédrine , Bonnin Marie-Ange , Hirsinger Estelle , Comai Glenda , Yvernogeau Laurent , Delfini Marie-Claire , Bellenger Léa , Mella Sébastien , Nassari Sonya , Robin Catherine , Schweitzer Ronen , Fournier-Thibault Claire , Jaffredo Thierry , Tajbakhsh Shahragim , Relaix Frédéric , Duprez Delphine
Published: June 2021

Positional information driving limb muscle patterning is contained in connective tissue fibroblasts but not in myogenic cells. Limb muscles originate from somites, while connective tissues originate from lateral plate mesoderm. With cell and genetic lineage tracing we challenge this model and identify an unexpected contribution of lateral plate-derived fibroblasts to the myogenic lineage, preferentially at the myotendinous junction. Analysis of single-cell RNA-sequencing data from whole limbs at successive developmental stages identifies a population displaying a dual muscle and connective tissue signature. BMP signalling is active in this dual population and at the tendon/muscle interface. In vivo and in vitro gain- and loss-of-function experiments show that BMP signalling regulates a fibroblast-to-myoblast conversion. These results suggest a scenario in which BMP signalling converts a subset of lateral plate mesoderm-derived cells to a myogenic fate in order to create a boundary of fibroblast-derived myonuclei at the myotendinous junction that controls limb muscle patterning.
Fibroblast fusion to the muscle fiber regulates myotendinous junction formation
Authors: Yaseen Wesal , Kraft-Sheleg Ortal , Zaffryar-Eilot Shelly , Melamed Shay , Sun Chengyi , Millay Douglas P. , Hasson Peleg
Published: June 2021

Vertebrate muscles and tendons are derived from distinct embryonic origins yet they must interact in order to facilitate muscle contraction and body movements. How robust muscle tendon junctions (MTJs) form to be able to withstand contraction forces is still not understood. Using techniques at a single cell resolution we reexamine the classical view of distinct identities for the tissues composing the musculoskeletal system. We identify fibroblasts that have switched on a myogenic program and demonstrate these dual identity cells fuse into the developing muscle fibers along the MTJs facilitating the introduction of fibroblast-specific transcripts into the elongating myofibers. We suggest this mechanism resulting in a hybrid muscle fiber, primarily along the fiber tips, enables a smooth transition from muscle fiber characteristics towards tendon features essential for forming robust MTJs. We propose that dual characteristics of junctional cells could be a common mechanism for generating stable interactions between tissues throughout the musculoskeletal system.
scGCN is a graph convolutional networks algorithm for knowledge transfer in single cell omics
Authors: Song Qianqian , Su Jing , Zhang Wei
Published: June 2021

Single-cell omics is the fastest-growing type of genomics data in the literature and public genomics repositories. Leveraging the growing repository of labeled datasets and transferring labels from existing datasets to newly generated datasets will empower the exploration of single-cell omics data. However, the current label transfer methods have limited performance, largely due to the intrinsic heterogeneity among cell populations and extrinsic differences between datasets. Here, we present a robust graph artificial intelligence model, single-cell Graph Convolutional Network (scGCN), to achieve effective knowledge transfer across disparate datasets. Through benchmarking with other label transfer methods on a total of 30 single cell omics datasets, scGCN consistently demonstrates superior accuracy on leveraging cells from different tissues, platforms, and species, as well as cells profiled at different molecular layers. scGCN is implemented as an integrated workflow as a python software, which is available at https://github.com/QSong-github/scGCN.
Observation of current-induced switching in non-collinear antiferromagnetic IrMn3 by differential voltage measurements
Authors: Arpaci Sevdenur , Lopez-Dominguez Victor , Shi Jiacheng , Sánchez-Tejerina Luis , Garesci Francesca , Wang Chulin , Yan Xueting , Sangwan Vinod K. , Grayson Matthew A. , Hersam Mark C. , Finocchio Giovanni , Khalili Amiri Pedram
Published: June 2021

There is accelerating interest in developing memory devices using antiferromagnetic (AFM) materials, motivated by the possibility for electrically controlling AFM order via spin-orbit torques, and its read-out via magnetoresistive effects. Recent studies have shown, however, that high current densities create non-magnetic contributions to resistive switching signals in AFM/heavy metal (AFM/HM) bilayers, complicating their interpretation. Here we introduce an experimental protocol to unambiguously distinguish current-induced magnetic and nonmagnetic switching signals in AFM/HM structures, and demonstrate it in IrMn3/Pt devices. A six-terminal double-cross device is constructed, with an IrMn3 pillar placed on one cross. The differential voltage is measured between the two crosses with and without IrMn3 after each switching attempt. For a wide range of current densities, reversible switching is observed only when write currents pass through the cross with the IrMn3 pillar, eliminating any possibility of non-magnetic switching artifacts. Micromagnetic simulations support our findings, indicating a complex domain-mediated switching process.
Abemaciclib as initial therapy for advanced breast cancer: MONARCH 3 updated results in prognostic subgroups
Authors: Johnston Stephen , O’Shaughnessy Joyce , Martin Miguel , Huober Jens , Toi Masakazu , Sohn Joohyuk , André Valérie A. M. , Martin Holly R. , Hardebeck Molly C. , Goetz Matthew P.
Published: June 2021

In MONARCH 3, continuous dosing of abemaciclib with an aromatase inhibitor (AI) conferred significant clinical benefit to postmenopausal women with HR+, HER2− advanced breast cancer. We report data for clinically prognostic subgroups: liver metastases, progesterone receptor status, tumor grade, bone-only disease, ECOG performance status, and treatment-free interval (TFI) from an additional 12-month follow-up (after final progression-free survival [PFS] readout). In the intent-to-treat population, after median follow-up of approximately 39 months, the updated PFS was 28.2 versus 14.8 months (hazard ratio [HR], 0.525; 95% confidence interval, 0.415–0.665) in abemaciclib versus placebo arms, respectively. Time to chemotherapy (HR, 0.513), time to second disease progression (HR, 0.637), and duration of response (HR, 0.466) were also statistically significantly prolonged with the addition of abemaciclib to AI. Treatment benefit was observed across all subgroups, as evidenced by objective response rate change from the addition of abemaciclib to AI, with the largest effects observed in patients with liver metastases, progesterone receptor-negative tumors, high-grade tumors, or TFI < 36 months. Extended follow-up in the MONARCH 3 trial further confirmed that the addition of abemaciclib to AI conferred significant treatment benefit to all subgroups, including those with poorer prognosis.
Optimal two-qubit circuits for universal fault-tolerant quantum computation
Authors: Glaudell Andrew N. , Ross Neil J. , Taylor Jacob M.
Published: June 2021

We study two-qubit circuits over the Clifford+CS gate set, which consists of the Clifford gates together with the controlled-phase gate CS = diag(1, 1, 1, i). The Clifford+CS gate set is universal for quantum computation and its elements can be implemented fault-tolerantly in most error-correcting schemes through magic state distillation. Since non-Clifford gates are typically more expensive to perform in a fault-tolerant manner, it is often desirable to construct circuits that use few CS gates. In the present paper, we introduce an efficient and optimal synthesis algorithm for two-qubit Clifford+CS operators. Our algorithm inputs a Clifford+CS operator U and outputs a Clifford+CS circuit for U, which uses the least possible number of CS gates. Because the algorithm is deterministic, the circuit it associates to a Clifford+CS operator can be viewed as a normal form for that operator. We give an explicit description of these normal forms and use this description to derive a worst-case lower bound of $$5{{\rm{log}}}_{2}(\frac{1}{\epsilon })+O(1)$$

5

log

2

(

1

ϵ

)

+
O

(

1

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on the number of CS gates required to ϵ-approximate elements of SU(4). Our work leverages a wide variety of mathematical tools that may find further applications in the study of fault-tolerant quantum circuits.