bluuebunny/crossref_metadata_2025 huggingface dataset:
Longitudinal observations of the effects of ischemic stroke on binaural perception
Authors: Dietze Anna , Sörös Peter , Pöntynen Henri , Witt Karsten , Dietz Mathias
Published: February 2024

Acute ischemic stroke, characterized by a localized reduction in blood flow to specific areas of the brain, has been shown to affect binaural auditory perception. In a previous study conducted during the acute phase of ischemic stroke, two tasks of binaural hearing were performed: binaural tone-in-noise detection, and lateralization of stimuli with interaural time- or level differences. Various lesion-specific, as well as individual, differences in binaural performance between patients in the acute phase of stroke and a control group were demonstrated. For the current study, we re-invited the same group of patients, whereupon a subgroup repeated the experiments during the subacute and chronic phases of stroke. Similar to the initial study, this subgroup consisted of patients with lesions in different locations, including cortical and subcortical areas. At the group level, the results from the tone-in-noise detection experiment remained consistent across the three measurement phases, as did the number of deviations from normal performance in the lateralization task. However, the performance in the lateralization task exhibited variations over time among individual patients. Some patients demonstrated improvements in their lateralization abilities, indicating recovery, whereas others’ lateralization performance deteriorated during the later stages of stroke. Notably, our analyses did not reveal consistent patterns for patients with similar lesion locations. These findings suggest that recovery processes are more individual than the acute effects of stroke on binaural perception. Individual impairments in binaural hearing abilities after the acute phase of ischemic stroke have been demonstrated and should therefore also be targeted in rehabilitation programs.
Progress in research on the effects of quinoa (Chenopodium quinoa) bioactive compounds and products on intestinal flora
Authors: Huang Honglan , Jia Chengxuan , Chen Xinying , Zhang Li , Jiang Yang , Meng Xianglong , Liu Xianjun
Published: February 2024

Quinoa is a highly nutritious whole-grain crop with unique values as both a food and medicinal supplement. At present, the roles played by the intestinal microflora in human health are gaining considerable attention from the research community, and studies to date have shown that the occurrence of a range of diseases may be associated with an imbalance of the intestinal flora. The bioactive compounds of quinoa affect the production of SCFAs and the adjustment of intestinal pH. In this article, we review the mechanisms underlying the effects of different quinoa constituents on the intestinal flora, the effects of these constituents on the intestinal flora of different hosts, and progress in research on the therapeutic properties of quinoa constituents, to provide a better understanding of quinoa in terms its dual medicinal and nutritional properties. We hope this review will provide a useful reference for approaches that seek to enhance the composition and activities of the intestinal flora.
Creating healthy eating and active environments in early learning settings: protocol of the CHEERS eHealth intervention study
Authors: Lafave Lynne M. Z. , Hayek Joyce , Webster Alexis D. , McConnell Ceilidh
Published: February 2024

Background

Early childhood educators through their daily interactions with children, play a central role in shaping young children’s health behaviors. Given their influential role, early childhood educators are often targeted in interventions aiming at enhancing their nutrition and physical activity practices.

Methods

This paper presents the design of the CHEERS eHealth program to improve nutrition and physical activity practices within Early Childhood Education and Care (ECEC) centers. The study has a longitudinal quasi-experimental design with recruitment of ECECs across Alberta Canada. ECEC intervention group educators complete 12 weekly online nutrition and physical activity modules and participate in weekly communities of practice sessions to discuss practical applications within their centers. Outcome assessments are scheduled at baseline (T1), mid-point at 5 months (T2), and end of program after 10 months (T3). Outcome measures include the Creating Healthy Eating and Active Environments survey (CHEERS), Mindful Eating Questionnaire (MEQ), Canadian Behavior, Attitude and Nutrition Knowledge Survey (C-BANKS 2.0), Physical Literacy Knowledge, Attitude, Self-Efficacy, and Behavior (PLKASB-ECE), the Environment and Policy Assessment and Observation (EPAO) derived variables, and an objective measure of children’s physical activity using ActiGraph GT3X accelerometers. Linear mixed model analyses will be used to evaluate the effectiveness of the intervention. Qualitative assessments comprise exit interviews and open-response questions embedded within the educational modules.

Results

Preliminary baseline data from the 2019 cohort indicate no statistically significant differences between the intervention and control groups for the primary outcome variables, except age. Educators’ personal nutrition-related knowledge, attitude and behaviors were positively associated with their self-assessments of the nutrition environment and practices in ECECs. A significant correlation was observed between educators’ self-reported physical activity practices and observed activity practices. The CHEERS survey Food Served subscale showed a positive correlation with the objective measures of EPAO-Foods Provided and Nutrition Policy subdomains.

Discussion

We propose that this eHealth intervention would be an effective scaling up approach to enhancing the nutrition and physical activity environments of ECECs by fostering improved nutrition and physical activity-related knowledge, attitudes, and adherence to best practices which will potentially lead to improved outcomes for children in their care.
Effect of high NEFA concentration on lipid metabolism disorders in hepatocytes based on lipidomics
Authors: Fan Xinyi , Xu Jie , Hu Yuan , Wang Kui , Zhao Yiyi , Cai Jinyin , Zhang Xinyuan , Pan Binghai , Xu Anqi , Chen Yajing , Liu Songhao , Jiang Kangfeng , Li Xiaobing
Published: February 2024

Introduction: High concentrations of nonesterified fatty acids (NEFA) is the key of characteristic of fatty liver in dairy cows. Therefore, the aim of this study was to investigate the effect of high concentration of NEFA on lipid metabolism in hepatocytes through the lipidomic approach and molecular biology techniques.

Methods: Stimulate AML-12 cells with different concentrations of NEFA, observe the cellular lipid accumulation, and select 0.6 mM NEFA stimulation concentration for subsequent experiments. Collect cells for lipidomics analysis.

Results: High concentration of NEFA (0.6–2.4 mM) significantly reduced the cell viability in a concentration-dependent manner, indicating that high concentrations of NEFA have lipotoxicity on hepatocytes. In addition, NEFA promoted triglycerides (TAG) accumulation, increased the mRNA expression of the lipogenic molecules SREBP1c and FASN, and decreased the mRNA expression of lipolytic molecules CPT1A and HSL in hepatocytes. Mechanistically, high concentration of NEFA induced lipid metabolism disorders in hepatocytes by regulating metabolic pathways such as glycerol phospholipid metabolism, glycosyl phosphatidylinositol anchored biosynthesis, triglyceride metabolism, sphingolipid metabolism, and inositol phosphate metabolism.

Discussion: High concentration of NEFA is lipotoxic to cells, promoting lipid accumulation. LPE (18:2), LPE (18:3), LPE (18:1) via glycerophospholipid metabolism, glycosylphosphatidylinositol (GPI)-anchor biosynthesis, glycerolipid metabolism, sphingolipid metabolism, and inositol phosphate metabolism, indicating their potential regulation role in the pathogenesis of fatty liver.
Multiple scattering of Bessel beams propagating in advection fog and radiation fog
Authors: Chen Run , Zhang Yuanyuan , Xu Qiang , Han Yiping , Wu Zhensen
Published: February 2024

The Bessel beams scattering of the fog particles were calculated by using the plane beams angle spectrum expansion method, and the effects of the topological charge and the half-conic angle of the Bessel beam on the differential scattering cross-section were analyzed by numerical calculation. Based on the scattering results of a single fog particle by a Bessel beam, by Monte Carlo method, the propagation characteristics of the Bessel beam in fogs with different visibility are simulated, and the effects of the wavelength, topological charge and semi-conic angle of the Bessel beam on transmissivity and reflectivity are analyzed. The studies show the self-healing ability of the Bessel beams, and the propagation distance of the Bessel beam is longer than that of the plane beams in fogs.
Effect of intercropping with legumes at different rates on the yield and soil physicochemical properties of Cyperus esculentus L. in arid land
Authors: Shen Xin , Liu Yalan , Li Xiangyi , Li Lei
Published: February 2024

Intercropping has the potential to enhance yields and nutrient availability in resource-limited agricultural systems. However, the effects on crop yield nutrients and soil properties can vary considerably depending on the specific plant combinations and intercropping ratios used. In this study, the advantages and impacts of intercropping C. esculentus with legumes were investigated by measuring their biomass, nutrient content, and soil properties. The experiment included five intercropping treatments: monoculture of C. esculentus (MC), intercropping of C. esculentus with Medicago sativa L. (alfalfa) at row spacing ratios of 4:4 (4:4CM) and 8:4 (8:4CM), and intercropping of C. esculentus with Glycine max (L.) Merr. (soybean), also at row spacing ratios of 4:4 (4:4CG) and 8:4 (8:4CG). Our results demonstrated that all four intercropping treatments (4:4CM, 4:4CG, 8:4CM, and 8:4CG) significantly increased the biomass of C. esculentus by approximately 41.05%, 41.73%, 16.08%, and 18.43%, respectively, compared with monoculture cultivation alone, among which the 4:4CG treatment was optimum. However, no significant differences were observed in alfalfa or soybean biomass across different intercropping ratios. A notable increase was found in the total nitrogen (TN) and total phosphorus (TP) contents in the leaves, roots, and tubers of C. esculentus under intercropping, along with increased soil organic carbon (SOC), alkaline-hydrolyzed nitrogen (AN), available phosphorus (AP), microbial biomass carbon (MBC), microbial biomass nitrogen (MBN), and soil water content (SWC), and significantly reduced the soil pH. Among the intercropping treatments, the 4:4CG treatment also exhibited the most favorable soil properties. In particular, compared with MC, the 4:4CG treatment resulted in significant increases of 163.8%, 394.6%, and 716.8% in SOC, AN, and AP contents, respectively. The same treatment also led to significant increases of 48.34%, 46.40%, and 208.65% in MBC, MBN, and SWC, respectively. Overall, the findings suggest that the use of 4:4CG intercropping is an effective approach for sustainable farming management in Xinjiang.
Can professionals “keep the tiller straight” in organizations? Resistance to reframing and decoy alternatives in workplace decision-making
Authors: Angioletti Laura , Acconito Carlotta , Crivelli Davide , Balconi Michela
Published: February 2024

So far, little is known about the ability to contrast contextual bias as a protective factor in an ever-changing organizational environment. This study assessed whether professionals with different seniority can resist the reframing and the decoy effect under decision-making conditions and whether decision-making styles can predict the resistance to such covert influence tactics. To reach this aim, two groups of professionals divided into senior and junior professionals performed two novel tasks, a Resistance to Reframe Task (RRT) and a Resistance to Alternatives Task (RAT), which, by including ecological scenarios that represent typical decision situations that could arise in the company, can measure the resistance to such covert influence tactics. Decision-making styles were measured through the General Decision-Making Style (GDMS) and the Maximization Scale (MS). Results showed that all professionals were able to resist more to the reframing (at the RRT) than the decoy alternatives (RAT), without any difference between groups. In addition, higher GDMS-dependent subscale scores predict lower RRT scores, especially in the group of senior professionals. However, in the group of junior professionals, the GDMS-dependent subscale and MS high standards subscale predicted lower RAT scores. To conclude, this study showed that professionals know how to “keep the tiller straight” in organizations, especially when facing reframing conditions, rather than decoy alternatives; however, the predominance of dependent decision-making styles (for both senior and junior professionals) and the tendency to hold high standards in decisions (mainly for juniors) could undermine their resistance capacity and make them vulnerable to these covert influence tactics.
Influence of perceived social support on detection of social norm violation: evidence from N1 and N400
Authors: Liang Bing , Li Bingbing , Fan Xiaoyue , Mu Yan , Wang Juan
Published: February 2024

Introduction

The perceived social support individuals receive from their others plays a crucial role in shaping conformity with social norms. However, the specific mechanism underlying perceived social support and the detection of social norms remains unclear.

Methods

In this study, college students with high and low levels of perceived social support were asked to judge the appropriateness of stranger’s behaviors (e.g., singing) in different situations (e.g., library). The participants’ electroencephalography activities were analyzed aiming to uncover the neural mechanism underlying how perceived social support influences the detection of others’ normative behavior.

Results

The ERP results indicate that, for individuals with a lower level of perceived social support, larger amplitudes of the N1 component (related to primary processing) and the N400 component (related to cognitive conflict) were observed when detecting others’ social norm violation compared to the conformity condition. However, for individuals with a higher level of perceived social support, no significant differences were found in detecting others’ conformity or violation of social norms.

Discussion

The results indicate that, when the perceived social support level of the individual is low, detecting others’ social norm violation elicits deeper primary processing and stronger cognitive conflict compared to conformity condition.
Gender differences in geriatric depressive symptoms in urban China: the role of ADL and sensory and communication abilities
Authors: Guo Ling , Fang Mingwang , Wang Lingying , Liu Li , He Chunxia , Zhou Xiumei , Lu Yi , Hu Xiuying
Published: February 2024

Objectives

ADL and Sensory and Communication Abilities are important indicators of the quality of life of the elderly which are significant determinants of health, particularly in developing countries. The present cross-sectional study investigated effect of ADL and Sensory and Communication Abilities on depressive symptoms, as well as the the role of gender in these effects.

Design

This is a cross-sectional study.

Setting

A nationally representative cross-sectional survey among the Chinese population aged 60 years and over.

Participants

A total of 163296 females and 148724 males aged 65 and over in 2019 in urban China.

Outcome measures

Prevalence, risk factors and gender differences in geriatric depressive symptoms among urban elderly.

Results

Approximately 95.69% of the participants had depressive symptoms according to the CESD-10, with no statistically significant gender difference of 52.15% in females and 47.85% in males. Logistic regression findings suggest that geriatric depressive symptoms are significantly associated with the lack of eldercare (OR=2.427, female; OR=1.426, male), living alone(OR= 1.430, female; OR= 1.179, male), ADL dysfunction (OR=1.528, female; OR=1.246, male), and impaired sensory and communication ability (OR=1.338, female; OR=1.185, male) among both female and male participants. Remarkably, geriatric depressive symptoms are only significantly associated with age (≥75, OR = 1.327), marital status (unmarried, OR=1.598), the number of children (no children, OR=2.271), and the living arrangement (living alone, OR= 1.430) among female participants.

Conclusion

Significant gender differences in these associations were found for living alone, ADL dysfunction and impaired sensory and communication ability. Moreover, the study emphasized that the gender difference exists in terms of geriatric depression in urban China. Females are more likely to experience depressive than males with the same circumstances.
The impact of street greenery on active travel: a narrative systematic review
Authors: Yu Jiahua , Zhang Hao , Dong Xinyang , Shen Jing
Published: February 2024

Background

Street greenery may have a profound effect on residents’ active travel (AT), a mode of transportation involving walking and cycling. This study systematically reviewed the scientific evidence on the effects of street greenery on active travel.

Methods

A comprehensive search was performed using keywords and references in PubMed, Web of Science, Scopus, and Cochrane Library. The review included studies that met the following criteria: (1) Study design: experimental studies, cross sectional studies, (2) Participants: individuals of all ages, (3) Exposure variables: street greenery, including street vegetation (e.g., trees, shrubs, and lawns), (4) Outcomes: active travel behaviors (walking, cycling), (5) Article type: peer-reviewed articles, (6) Search time window: from the inception of relevant electronic literature database until 21 June 2023, (7) Geographic scope: worldwide; (8) Language: articles in English.

Results

Twenty-six cross-sectional studies met the inclusion criteria and were analyzed. These studies employed objective metrics for assessing street greenery and varied methodologies to measure AT, including 14 using subjective measurements (like self-reported surveys), 10 using objective data (such as mobile app analytics), and two studies combined both approaches. This review identifies a generally positive impact of street greenery on active travel in various aspects. However, the extent of this influence varies with factors such as temporal factors (weekdays vs. weekends), demographic segments (age and gender), proximity parameters (buffer distances), and green space quantification techniques. Street greenness promotes active travel by enhancing environmental esthetics, safety, and comfort, while also improving air quality, reducing noise, and fostering social interactions. In addition, the study suggests that variables like weather, seasonality, and cultural context may also correlate with the effectiveness of street greenery in encouraging active travel.

Conclusion

Street greenery positively influences active travel, contributing to public health and environmental sustainability. However, the findings also indicate the need for more granular, experimental, and longitudinal studies to better understand this relationship and the underlying mechanisms. These insights are pivotal for urban planners and policymakers in optimizing green infrastructure to promote active transportation, taking into account local demographics, socio-economic factors, and urban design.
Gender considerations in One Health: a framework for researchers
Authors: Galiè Alessandra , McLeod Anni , Campbell Zoë A. , Ngwili Nicholas , Terfa Zelalem G. , Thomas Lian F.
Published: February 2024

One Health research and intervention outcomes are strongly influenced by gender dynamics. Women, men, girls, and boys can be negatively affected by gender-based disadvantage in any of the three One Health domains (animal, human, and environmental health), and where this occurs in more than one domain the result may be a compounding of inequity. Evidence worldwide shows that women and girls are more likely to suffer from such gender-based disadvantage. A thoughtfully implemented One Health intervention that prioritizes gender equity is more likely to be adopted, has fewer unintended negative consequences, and can support progress toward gender equality, however there is limited evidence and discussion to guide using a gender lens in One Health activities. We propose a framework to identify key gender considerations in One Health research for development – with a focus on Low-and Middle-Income Countries. The framework encourages developing two types of research questions at multiple stages of the research process: those with a bioscience entry-point and those with a gender entry-point. Gender considerations at each stage of research, institutional support required, and intervention approaches is described in the framework. We also give an applied example of the framework as it might be used in One Health research. Incorporation of gender questions in One Health research supports progress toward more equitable, sustainable, and effective One Health interventions. We hope that this framework will be implemented and optimized for use across many One Health challenge areas with the goal of mainstreaming gender into One Health research.
Heavy metal contamination in duck eggs from a mercury mining area, southwestern China
Authors: Guo Xiaoling , Wang Zhuhong , Li Xue , Liao Jing , Zhang Xue , Ran Yulin , Wu Qixin , Zhang Ting , Wang Zhongwei
Published: February 2024

Objective

Mercury (Hg) contamination in the environment around mercury mines is often accompanied by heavy metal contamination.

Methods

Here, we determined concentrations of chromium (Cr), zinc (Zn), strontium (Sr), barium (Ba), and lead (Pb) in duck eggs from a Hg mining area in Southwest China to assess the contamination and health risk.

Results

Duck eggs obtained from the mining area exhibit higher concentrations of Cr, Zn, Sr, Ba, and Pb compared to those from the background area, with egg yolks containing higher metal levels than egg whites. Specifically, the mean Cr, Zn, Sr, Ba, and Pb concentrations of duck eggs from the Hg mining area are 0.38, 63.06, 4.86, 10.08, and 0.05 μg/g, respectively, while those from the background area are only 0.21, 24.65, 1.43, 1.05, and 0.01 μg/g. Based on the single-factor contamination index and health risk assessment, heavy metal contamination in duck eggs poses an ecological risk and health risk.

Conclusion

This study provides important insight into heavy metal contamination in duck eggs from Hg mining areas.
Farmer-preferred traits and variety choices for finger millet in Uganda
Authors: Hamba Sophia , Kasule Faizo , Mayanja Ibrahim , Biruma Moses , Natabirwa Hedwig , Sanya Losira Nasirumbi , Rubin Deborah , Occelli Martina , Adikini Scovia
Published: February 2024

Finger millet is a climate-resilient crop providing food and nutrition security and income In Uganda. However, the current productivity of finger millet in farmers’ fields is low and among other factors, this is due to the poor adoption of improved varieties. With this study we aim to identify and profile varietal traits preferred by finger millet farmers and consumers in Uganda. We specifically focus on how these traits vary among women and men in the Ugandan finger millet value chain. We collect data using semi-structured questionnaires among 170 households growing millet in Bushenyi, Lira, and Nwoya districts, and we triangulate questionnaires replies with qualitative information from 11 focus group discussions and 3 key informant interviews. Using descriptive statistics and probit regression models, we find that the majority of the farmers (97%) prefer growing landrace varieties of finger millet compared to only 3% growing improved varieties. The most preferred varieties were Kaguma in Bushenyi, Ajuko Manyige in Nwoya, Kal Atar, and Okello Chiba in Lira. Farmers’ choice of variety depends on a combination of traits including agronomic, marketing, and consumption traits. Gender, marital status, education levels, and occupation are the major socio-demographic factors that influence specific preferences related to finger millet variety. This study lays a foundation for designing a gender-responsive finger millet product profile to guide the development and release of new varieties by the finger millet crop improvement program.
Challenges of rabies surveillance in Madagascar based on a mixed method survey amongst veterinary health officers
Authors: Dreyfus Anou , Volasoa Marie Hermelienne , Guis Hélène , Razafindraibe Nivohanitra Perle , Razafindramparany Mino Harimbola , Arivony Nomenjanahary Lalaina , Rakotondrabe Naltiana , Andriamananjara Mamitiana Aimé , Dussart Philippe , Kassie Daouda , Lacoste Vincent , Andriamandimby Soa Fy
Published: February 2024

Introduction

In Madagascar, rabies is endemic and a notifiable disease. The objective of this mixed study was to understand the challenges faced by the Veterinary Health Officers (VHOs) in the current rabies surveillance system in Madagascar.

Methods

A survey was conducted from mid-April to the end of July 2021 during which all officially-listed VHOs (N = 150) were contacted by phone at least twice. Participants, representative of the 22 regions of Madagascar, were interviewed by phone based on a semi-structured questionnaire on (1) their knowledge of rabies epidemiology in their area of activities, (2) the occurrence of human and animal rabies and the species affected in the region where they work, (3) the factors that might influence rabies surveillance depending on (a) their activities and area of operation, (b) the socio-cultural aspects of local communities, and (c) the general organization of animal rabies surveillance.

Results

The majority (80/90) of VHOs declared having been informed of at least one suspected or confirmed case of human and/or animal rabies in their area of activity during their work as VHOs: at least once a month for 11 of them, at least once a year for 40 and with undetermined frequency for 29. Several obstacles hinder the surveillance of rabies resulting in under-reporting. The lack of funds to access suspect animals, collect, pack and ship samples in compliance with biosecurity measures and the cold chain, was mentioned as a major obstacle to surveillance. The second barrier is socio-cultural: in many large coastal regions, dogs are taboo and VHOs fear rejection by the community if they treat dogs.

Discussion and conclusion

While the general population requires information on the rabies situation in Madagascar and on how to proceed in the event of a bite, veterinarians and decision-makers need to be fully aware of an evidence-based approach to rabies surveillance, prevention and control. Communication between the human and animal health sectors should be improved. Politicians need to be persuaded of the importance of funding to eliminate rabies in Madagascar. The adoption, in early 2023, of a national strategic plan for rabies control is a first step in this direction.
Laparoscopic treatment of congenital portosystemic shunts with portal pressure measurement and portal angiography in 36 dogs
Authors: Shigemoto Jin , Kaneko Yasuyuki , Kawazu Mitsunobu , Naganobu Kiyokazu , Torisu Shidow
Published: February 2024

Introduction

Laparoscopic surgery is used for canine congenital extrahepatic portosystemic shunts (CEHPSS). However, outcomes of laparoscopic surgery involving simultaneous portal vein angiography and portal pressure measurement to attenuate or completely occlude the shunt vessel in canines remain unclear. This study aimed to evaluate outcomes and complications of laparoscopic portosystemic shunt occlusion (LAPSSO) for CEHPSS.

Methods

Between June 2014 and March 2021, data on dogs undergoing cellophane banding (CB) and complete occlusion of laparoscopically treated congenital extrahepatic port shunts were collected from hospital records. Cases in which complete occlusion was laparoscopically performed, or a CB was used for gradual occlusion were included. A total of 36 dogs (14 males; median age 32.5 months [range, 5–99] with median body weight, 4.2 kg [range, 1.5–7.9]) that underwent LAPSSO for CEHPSS were included. All the dogs underwent computed tomographic angiography (CTA), and data on blood and radiological examinations were collected. Shunt vessel morphology was categorized using CTA findings. Portal pressure measurements and portal angiography were performed by accessing mesenteric and splenic veins in 30 and 6 cases, respectively.

Results

The most common shunt types were spleno-phrenic shunts 16/36 (44.4%), followed by spleno-azygos 9/36 (25.0%), spleno-caval 4/36 (11.1%), right gastric-caval 6/36 (16.6%), and right gastric-caval with caudal loop shunts 1/36 (2.7%). The median portal pressure after complete occlusion was 11.5 mmHg (range, 4–16); portal pressures in the two dogs undergoing CB attenuation were 22 and 24 mmHg. The median operating time in the dogs with right (n = 25) and left (n = 11) recumbent positioning was 55 min (range, 28–120) and 54 min (range, 28–88), respectively. One dog had pneumothorax due to injury to the diaphragm. Another dog developed postoperative hypernatremia and succumbed 5 h post-procedure. Nevertheless, no other dogs exhibited signs of portal hypertension within 72 h. Blood tests and abdominal ultrasounds performed 1–2 months postoperatively revealed no residual shunts.

Discussion

LAPSSO, coupled with portal pressure measurement and portal angiography, was shown as safe and effective approach that facilitated successful occlusion of CEHPSS. Further large-scale prospective studies and analyses of perioperative complications are needed.
Proposal for a Human–Machine Collaborative Transfer System Considering Caregivers’ Lower Back Pain and Cognitive Factors in the Elderly during Transfer Movements
Authors: Wu Jiang , Shino Motoki
Published: February 2024

With the aging society in Japan, the number of elderly people residing in elderly facilities is increasing. In previous study, we developed a transfer assistive device designed to aid the elderly in transferring from the bedroom to the bathroom. Additionally, the device assists the elderly with standing and sitting to facilitate independent toileting activities. We verified that, throughout the entire transfer movement, the lumbar burden on caregivers remained below 3400 N. In this study, based on quantitative evaluation indices of transfer movements, the relationship between the lumbar burden on caregivers and factors such as psychological anxiety or cognitive impairment in the elderly during the use of a transfer assistive device was elucidated through motion analysis. We developed a control algorithm for the human–machine collaborative transfer system with the aim of alleviating the strain on the caregiver’s lower back while ensuring the elderly can use the device with peace of mind. The practicality of the control algorithm was verified.
Research on Path Tracking Fault-Tolerant Control Strategy for Intelligent Commercial Vehicles Based on Brake Actuator Failure
Authors: Cui Guanjie , Bao Chunjiang , Guo Mingjie , Xu Yahui , He Yelin , Wu Jian
Published: February 2024

With the development of safety technologies for intelligent commercial vehicles, electronic pneumatic braking systems (EBSs) have been widely used. However, EBS actuators may fail during vehicle operation and thus create safety problems. For this reason, we propose a path-tracking fault-tolerant control strategy under EBS actuator failure in intelligent commercial vehicles. First, in order to be able to characterize different types of brake actuator faults during the EBS differential braking process of a vehicle, a comprehensive fault coefficient for calculating the degree of fault is designed, and a BES generalized fault model is established. Second, the faults are introduced into the fault-tolerant controller through the comprehensive fault coefficients for braking torque calculation and braking pressure allocation. Thus, a vehicle path model with the complete fault coefficients as variable parameters is established. Then, based on the LPV system gain scheduling, a path-tracking LPV/H∞ fault-tolerant controller under EBS actuator faults in commercial vehicles is designed, which is used to solve the safety problem arising from sudden EBS actuator faults. Finally, we conducted experimental validation through hardware-in-the-loop tests. The results demonstrate that the control strategy designed in this paper redistributes the braking torque and synergizes with the steering system to enhance vehicle stability, thereby improving vehicle safety in the EBS failure mode.
Influence of Genotype on Antioxidant Activity and Phenolic Profile of Fennel Bulbs
Authors: Rubio Alfonso , López-Orenes Antonio , Ferrer María A. , Calderón Antonio A.
Published: February 2024

Currently, fennel bulb is becoming a highly demanded and consumed vegetable due to its licorice flavor and health benefits. Although the chemical composition of fennel essential oil has been extensively studied, the nonvolatile bioactive compounds of fennel bulbs have drawn less attention. Here, the phenolic profile and the antioxidant activity in terms of DPPH radical scavenging activity, reducing power, chelating ability of ferrous ions, and inhibition of lipid peroxidation were analyzed using four different fennel hybrid genotypes and three different extraction solvents (methanol, aqueous-methanol, and hot water). Antioxidant activity results revealed significant variation amongst fennel varieties (>3-fold difference for DPPH and reducing power and >2.7-fold for the inhibition of lipid peroxidation), with methanolic extracts exhibiting the highest antioxidant activity. Total phenol content peaked in the aqueous-methanol extracts, exhibiting a 2-fold difference across fennel genotypes. HPLC–PDA/MS analyses identified high levels of caffeic acid derivatives in hot water extracts, particularly in the commercial genotype. The therapeutic benefits associated with these compounds make it reasonable to use detailed phytochemical screening in fennel breeding programs to obtain varieties with new functionalities and thus higher added value.
Quinoa–Olive Agroforestry System Assessment in Semi-Arid Environments: Performance of an Innovative System
Authors: Abidi Ilham , Daoui Khalid , Abouabdillah Aziz , Belqadi Loubna , Mahyou Hamid , Bazile Didier , Douaik Ahmed , Gaboun Fatima , Hassane Sidikou Abdel Aziz , Alaoui Si Bennasseur
Published: February 2024

Agroforestry is a promising way to sustain land use efficiency in semi-arid areas. In this study, we introduce quinoa as a drought- and salinity-tolerant crop in olive-based agroforestry. We investigated how the microclimate created by olive trees affects agronomic and biochemical traits in quinoa and evaluated the performance of this new olive-based agroforestry system in terms of land equivalent ratio (LER). Field experiments were carried out under two pedoclimatic conditions (S1) and (S2) using a randomized complete block design with two cropping systems (sole crop (SCS) and agroforestry (AFS) systems), four quinoa cultivars (Puno, Titicaca, ICBA-Q5, and ICBA-Q4) and one olive orchard as a control (OR) in each block. Our results show that AFS had lower grain yield (−45%), dry biomass (−49%), and crop water productivity (−44%), but higher plant height (12%), grain protein (4%), saponin (26%), total polyphenol (12%), and DPPH (9%) contents compared to SCS. The highest grain yield was recorded for Titicaca and ICBA-Q5 (1.6 t ha−1). The LER ranged from 1.57 to 2.07, indicating that the overall productivity was 57% to 107% higher in the agroforestry system compared with the monoculture. We suggest that quinoa–olive tree intercropping could be a promising agroecological practice under semi-arid conditions.
Overview of Cyanide Poisoning in Cattle from Sorghum halepense and S. bicolor Cultivars in Northwest Italy
Authors: Giantin Stefano , Franzin Alberico , Brusa Fulvio , Montemurro Vittoria , Bozzetta Elena , Caprai Elisabetta , Fedrizzi Giorgio , Girolami Flavia , Nebbia Carlo
Published: February 2024

Sorghum plants naturally produce dhurrin, a cyanogenic glycoside that may be hydrolysed to cyanide, resulting in often-lethal toxicoses. Ruminants are particularly sensitive to cyanogenic glycosides due to the active role of rumen microbiota in dhurrin hydrolysis. This work provides an overview of a poisoning outbreak that occurred in 5 farms in Northwest Italy in August 2022; a total of 66 cows died, and many others developed acute toxicosis after being fed on either cultivated (Sorghum bicolor) or wild Sorghum (Sorghum halepense). Clinical signs were recorded, and all cows received antidotal/supportive therapy. Dead animals were subjected to necropsy, and dhurrin content was determined in Sorghum specimens using an LC–MS/MS method. Rapid onset, severe respiratory distress, recumbency and convulsions were the main clinical features; bright red blood, a bitter almond smell and lung emphysema were consistently observed on necropsy. The combined i.v. and oral administration of sodium thiosulphate resulted in a rapid improvement of clinical signs. Dhurrin concentrations corresponding to cyanide levels higher than the tolerated threshold of 200 mg/kg were detected in sorghum specimens from 4 out of 5 involved farms; thereafter, such levels declined, reaching tolerable concentrations in September–October. Feeding cattle with wild or cultivated Sorghum as green fodder is a common practice in Northern Italy, especially in summer. However, care should be taken in case of adverse climatic conditions, such as severe drought and tropical temperatures (characterising summer 2022), which are reported to increase dhurrin synthesis and storage.
Effects of Dietary Terminalia chebula Extract on Growth Performance, Immune Function, Antioxidant Capacity, and Intestinal Health of Broilers
Authors: Cheng Ying , Liu Shida , Wang Fang , Wang Tao , Yin Lichen , Chen Jiashun , Fu Chenxing
Published: February 2024

Terminalia chebula extract (TCE) has many physiological functions and is potentially helpful in maintaining poultry health, but its specific effect on the growth of broilers is not yet known. This research investigated the effects of dietary Terminalia chebula extract (TCE) supplementation on growth performance, immune function, antioxidant capacity, and intestinal health in yellow-feathered broilers. A total of 288 one-day-old yellow-feathered broilers were divided into four treatment groups (72 broilers/group), each with six replicates of 12 broilers. The broilers were given a basal diet of corn–soybean meal supplemented with 0 (control), 200, 400, and 600 mg/kg TCE for 56 d. The results demonstrated that, compared with the basal diet, the addition of TCE significantly increased (linear and quadratic, p < 0.05) the final body weight and overall weight gain and performance and decreased (linear and quadratic, p < 0.05) the feed-to-gain ratio in the overall period. Dietary TCE increased (linear, p < 0.05) the levels of IgM, IL-4, and IL-10 and decreased (linear and quadratic, p < 0.05) the level of IL-6 in the serum. Dietary TCE increased (linear and quadratic, p < 0.05) the levels of IL-2 and IL-4, decreased (linear and quadratic, p < 0.05) the level of IL-1β, and decreased (linear, p < 0.05) the level of IL-6 in the liver. Dietary TCE increased (linear and quadratic, p < 0.05) the level of IgM and IL-10, increased (linear, p < 0.05) the level of IgG, and decreased (linear and quadratic, p < 0.05) the levels of IL-1β and IL-6 in the spleen. Supplementation with TCE linearly and quadratically increased (p < 0.05) the catalase, superoxide dismutase, glutathione peroxidase, and total antioxidant capacity activities while decreasing (p < 0.05) the malonic dialdehyde concentrations in the serum, liver, and spleen. TCE-containing diets for broilers resulted in a higher (linear and quadratic, p < 0.05) villus height, a higher (linear and quadratic, p < 0.05) ratio of villus height to crypt depth, and a lower (linear and quadratic, p < 0.05) crypt depth compared with the basal diet. TCE significantly increased (linear, p < 0.05) the acetic and butyric acid concentrations and decreased (quadratic, p < 0.05) the isovaleric acid concentration. Bacteroidaceae and Bacteroides, which regulate the richness and diversity of microorganisms, were more abundant and contained when TCE was added to the diet. In conclusion, these findings demonstrate that supplementing broilers with TCE could boost their immune function, antioxidant capacity, and gut health, improving their growth performance; they could also provide a reference for future research on TCE.
A Metric-Based Few-Shot Learning Method for Fish Species Identification with Limited Samples
Authors: Lu Jiamin , Zhang Song , Zhao Shili , Li Daoliang , Zhao Ran
Published: February 2024

Fish species identification plays a vital role in marine fisheries resource exploration, yet datasets related to marine fish resources are scarce. In open-water environments, various fish species often exhibit similar appearances and sizes. To solve these issues, we propose a few-shot learning approach to identifying fish species. Our approach involves two key components. Firstly, the embedding module was designed to address the challenges posed by a large number of fish species with similar phenotypes by utilizing the distribution relationships of species in the embedding space. Secondly, a metric function was introduced, effectively enhancing the performance of fish species classification and successfully addressing the issue of limited sample quantity. The proposed model is trained end to end on fish species public datasets including the Croatian fish dataset, Fish4Knowledge and WildFish. Compared with the prototypical networks, our method performs more effectively and improves accuracy by 2% to 10%; it is able to identify fish effectively in small samples sizes and complex scene scenarios. This method provides a valuable technological tool for the development of fisheries resources and the preservation of fish biodiversity.
A Cyclam Salt as an Antifungal Agent: Interference with Candida spp. and Cryptococcus neoformans Mechanisms of Virulence
Authors: Cerqueira Fátima , Medeiros Rui , Lopes Inês , Campos Carla , Ferraz Maria Pia , Silva Fernando , Alves Luís G. , Pinto Eugénia
Published: February 2024

The importance of fungal infections, particularly those caused by yeasts, is increasing among the medical community. Candida albicans and Cryptococcus neoformans are amongst the high-priority fungal species identified by the World Health Organization (WHO) and are considered in the critical group, while Candida krusei is included in the medium-priority group. The cyclam salt H4[H2(4-CF3PhCH2)2Cyclam]Cl4 proved to be active against the growth of these three yeasts, and the aim of this work was to verify its interference with their virulence mechanisms, whether shared or unique. H4[H2(4-CF3PhCH2)2Cyclam]Cl4 significantly inhibited biofilm production and catalase activity, being able to interfere with C. albicans dimorphic transition and C. neoformans melanin production. At the minimal inhibitory concentration (MIC) values, H4[H2(4-CF3PhCH2)2Cyclam]Cl4 had no antioxidant effect, as determined by the DPPH method. When using the RAW264.7 macrophage cell line, H4[H2(4-CF3PhCH2)2Cyclam]Cl4 reduced nitric oxide (NO) detection (the Griess reaction), but this effect was associated with a significant toxic effect on the cells.
Predictive Modeling of Phenotypic Antimicrobial Susceptibility of Selected Beta-Lactam Antimicrobials from Beta-Lactamase Resistance Genes
Authors: Rahman Md. Kaisar , Williams Ryan B. , Ajulo Samuel , Levent Gizem , Loneragan Guy H. , Awosile Babafela
Published: February 2024

The outcome of bacterial infection management relies on prompt diagnosis and effective treatment, but conventional antimicrobial susceptibility testing can be slow and labor-intensive. Therefore, this study aims to predict phenotypic antimicrobial susceptibility of selected beta-lactam antimicrobials in the bacteria of the family Enterobacteriaceae from different beta-lactamase resistance genotypes. Using human datasets extracted from the Antimicrobial Testing Leadership and Surveillance (ATLAS) program conducted by Pfizer and retail meat datasets from the National Antimicrobial Resistance Monitoring System for Enteric Bacteria (NARMS), we used a robust or weighted least square multivariable linear regression modeling framework to explore the relationship between antimicrobial susceptibility data of beta-lactam antimicrobials and different types of beta-lactamase resistance genes. In humans, in the presence of the blaCTX-M-1, blaCTX-M-2, blaCTX-M-8/25, and blaCTX-M-9 groups, MICs of cephalosporins significantly increased by values between 0.34–3.07 μg/mL, however, the MICs of carbapenem significantly decreased by values between 0.81–0.87 μg/mL. In the presence of carbapenemase genes (blaKPC, blaNDM, blaIMP, and blaVIM), the MICs of cephalosporin antimicrobials significantly increased by values between 1.06–5.77 μg/mL, while the MICs of carbapenem antimicrobials significantly increased by values between 5.39–67.38 μg/mL. In retail meat, MIC of ceftriaxone increased significantly in the presence of blaCMY-2, blaCTX-M-1, blaCTX-M-55, blaCTX-M-65, and blaSHV-2 by 55.16 μg/mL, 222.70 μg/mL, 250.81 μg/mL, 204.89 μg/mL, and 31.51 μg/mL respectively. MIC of cefoxitin increased significantly in the presence of blaCTX-M-65 and blaTEM-1 by 1.57 μg/mL and 1.04 μg/mL respectively. In the presence of blaCMY-2, MIC of cefoxitin increased by an average of 8.66 μg/mL over 17 years. Compared to E. coli isolates, MIC of cefoxitin in Salmonella enterica isolates decreased significantly by 0.67 μg/mL. On the other hand, MIC of ceftiofur increased in the presence of blaCTX-M-1, blaCTX-M-65, blaSHV-2, and blaTEM-1 by 8.82 μg/mL, 9.11 μg/mL, 8.18 μg/mL, and 1.04 μg/mL respectively. In the presence of blaCMY-2, MIC of ceftiofur increased by an average of 10.20 μg/mL over 14 years. The ability to predict antimicrobial susceptibility of beta-lactam antimicrobials directly from beta-lactamase resistance genes may help reduce the reliance on routine phenotypic testing with higher turnaround times in diagnostic, therapeutic, and surveillance of antimicrobial-resistant bacteria of the family Enterobacteriaceae.
Study on Load Distribution and Fatigue Elastic Life of Ball Screw under Ultimate Conditions
Authors: Lv Lei , Lu Changhou , Chen Shujiang , Wang Weike
Published: February 2024

When subjected to extreme loads and ultra-low cycling conditions, the primary mode of failure in a ball screw is that excessive plastic contact deformation of the raceway surface exceeds acceptable limits. Consequently, traditional fatigue life theories based on pitting fatigue are not applicable in this context. This study evaluated the load distribution within the ball screw, considering factors such as the nut position and screw length. The plastic deformation of the raceway surfaces is analyzed using Thornton’s elastoplastic theory. Furthermore, this paper integrates the concepts of plastic deformation and fatigue elastic life to investigate the fatigue elastic life of ball screws under extreme conditions. To validate the proposed approach, the calculated results are compared with those from previous experimental studies, confirming its effectiveness. When the ratio of the nut position to the screw length approaches 0.7, the fatigue elastic life of the ball screw achieves its maximum. An increase in screw length, load, or raceway conformity ratio leads to a decrease in fatigue elastic life. Conversely, an increase in contact angle and ball diameter enhances the fatigue elastic life.