bluuebunny/crossref_metadata_2025 huggingface dataset:
Agronomic performance of grain amaranth in the semi-arid region as a function of the planting arrangement
Authors: Gomes Victor E. de V. , Mesquita Rosilene O. , Nunes Liliane R. , Innecco Renato
Published: March 2024

ABSTRACT The potential effects of climate change on agricultural yields require a greater understanding of cropping systems that include underutilized agricultural crops with greater adaptive capacity to water and thermal stresses, such as grain amaranth (Amaranthus sp.). The aim of this work was to evaluate how the planting arrangement affects the agronomic performance of grain amaranth BRS Alegria (Amaranthus cruentus L.) grown under semi-arid conditions. One experiment was carried out in a complete randomized block design with five repetitions in a 2 x 3 factorial scheme (two row spacings - 30 and 40 cm; three plant spacings - 20; 30 and 40 cm); in two crop years, 2019 and 2020 in the municipality of Pentecoste, CE, Brazil. The evaluated characteristics were plant height, stem diameter, number of leaves, fresh matter yield, aboveground biomass yield (dry weight), grain yield, thousand-grain weight, lipid content, and harvest and lodging indexes. The evaluated planting arrangements did not affect plant height and number of leaves, but did affect stem diameter and lodging index, as the 40 cm plant spacing resulted in greater stem diameter and lower lodging index. Narrow spacing (30 x 20 cm) resulted in a higher lodging index but also resulted in a higher fresh matter yield, aboveground biomass, grain yield, harvest index and lipid content. Thousand-grain weight was greater at 30 x 40 cm spacing. The 30 x 20 cm arrangement can be recommended for the cultivation of grain amaranth in the study area.
Genetic parameter estimates in irrigated barley genotypes in the brazilian savanna of the Federal District
Authors: Thomé Rodolfo D. , Amabile Renato F. , Souza Nara O. S. , Malaquias Juaci V. , Melo João V. P.
Published: March 2024

ABSTRACT Barley is an important crop for Brazil and an advantageous alternative for irrigated cultivation in the Brazilian Savanna. The present study aimed to characterize and estimate genetic, phenotypic, and environmental parameters and select genotypes from the Embrapa Cerrados irrigated barley working collection. The experiment was established in Randomized Blocks with four replications under irrigation in Embrapa Cerrados, Planaltina-DF. The traits evaluated were grain yield, commercial classification of first grains, 1000-seed weight, plant height, lodging, and cycle. The genetic parameters and correlations between the traits evaluated were obtained. High values of heritability, in a broad sense, were verified. The high coefficients of genotypic variance and the high selective accuracy obtained corroborate the favorable environmental condition for the selection of genotypes. It was verified that the genotypic correlations were higher than the phenotypic correlation coefficients, showing a greater contribution of genetic factors in the expression of the traits. Earlier genotypes had higher grain yields, first-class commercial classification, 1000-seed weight, and height. There was a strong positive correlation between the commercial classification of first grains and 1000-seed weight. Genotypes PFC 2005143, PFC 2006134, and PFC 2004212 were selected for use in crossbreeding blocks within the Brazilian irrigated barley breeding program.
Dam-break due to overtopping failure: experiments in homogeneous earthfill dams
Authors: Von Ahn Bianca dos Santos , Manica Rafael
Published: March 2024

ABSTRACT This work physically simulates the effect of low and high flow rates and filling times of reservoirs and rupture due to overtopping (caused by intense rains) of small homogeneous silty-sand earthfill dams. The experiments seek to verify how input variations impact the formation of the breach and the rupture wave. The results show that different filling times, soil moisture and composition, and degree of compaction affect landfill saturation, failure time, and breach formation. The result confirms that smaller breaches with a higher degree of compaction led to a lower peak rupture flow compared to dams with low degree of compaction. The rupture hydrograph presents a faster descent stage than an exponential hydrograph. Simulations and models based on this law may minimize the effect of the dam-break wave, also impacting water resource decision-making for damage reduction. The results were extrapolated to a real prototype, providing information and a database for the studies of overtopping dam-break waves.
BEYOND TRADITIONAL TOOLS: EXPLORING CONVOLUTIONAL NEURAL NETWORKS AS INNOVATIVE PROGNOSTIC MODELS IN PANCREATIC DUCTAL ADENOCARCINOMA
Authors: AHMED H Shafeeq
Published: March 2024

ABSTRACT Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive and lethal form of cancer with limited prognostic accuracy using traditional factors. This has led to the exploration of innovative prognostic models, including convolutional neural networks (CNNs), in PDAC. CNNs, a type of artificial intelligence algorithm, have shown promise in various medical applications, including image analysis and pattern recognition. Their ability to extract complex features from medical images makes them suitable for improving prognostication in PDAC. However, implementing CNNs in clinical practice poses challenges, such as data availability and interpretability. Future research should focus on multi-center studies, integrating multiple data modalities, and combining CNN outputs with biomarker panels. Collaborative efforts and patient autonomy should be considered to ensure the ethical implementation of CNN-based prognostic models. Further validation and optimisation of CNN-based models are necessary to enhance their reliability and clinical utility in PDAC prognostication.
RATE OF INFECTION (TUBERCULOSIS) IN BRAZILIANS IBD PRIVATE PATIENTS: FOLLOW-UP 15 YEARS
Authors: CURY Didia B , CURY Liana C B , MICHELETTI Ana C , OLIVEIRA Rogério A , GONÇALVES José J S
Published: March 2024

ABSTRACT Background: Latent tuberculosis (LTB) is a condition where the patient is infected with Mycobacterium tuberculosis but does not develop active TB. There’s a possibility of tuberculosis (TB) activation following the introduction of anti-TNFs. Objective: To assess the risk of biological therapy inducing LTB during inflammatory bowel diseases (IBD) treatment over 15 years in a high-risk area in Brazil. Methods: A retrospective study of an IBD patients’ database was carried out in a private reference clinic in Brazil. All patients underwent TST testing and chest X-ray prior to treatment, and once a year after starting it. Patients were classified according to the Montreal stratification and risk factors were considered for developing TB. Results: Among the analyzed factors, age and gender were risk factors for LTB. DC (B2 and P) and UC (E2) patients showed a higher number of LTB cases with statistical significance, what was also observed for adalimumab and infliximab users, compared to other medications, and time of exposure to them favored it significantly. Other factors such as enclosed working environment have been reported as risk. Conclusion: The risk of biological therapy causing LTB is real, so patients with IBD should be continually monitored. This study reveals that the longer the exposure to anti-TNFs, the greater the risk.
Subjetividades de médicas y médicos en su encuentro con víctimas de violencia sexual en hospitales universitarios de Medellín, Antioquia, 2021-2022
Authors: Moreno-Realphe Sandra-Patricia
Published: March 2024

Resumen Objetivo: Comprender la expresión de las subjetividades de médicas(os) en su encuentro con víctimas de violencia sexual en urgencias hospitalarias. Metodología: Investigación cualitativa, diseño de caso colectivo, con enfoque etnográfico, con la elaboración de un diario de campo, dos itinerarios institucionales, dos entrevistas a coordinadoras, diez entrevistas en profundidad a médicas(os) y un encuentro reflexivo. Resultados: Se identificaron cuatro momentos en el recorrido de la víctima, y en ellos emergieron expresiones subjetivas que se agruparon en formas de reconocimiento y mecanismos. Se incorporaron el campo médico en el subcampo medicina moderna en sus habitus, sus prácticas clínicas vulneraron a las víctimas de violencia sexual. Por el contrario, si se apartaron de las lógicas que impuso el campo médico, sus prácticas se tradujeron en un cuidado comprensivo. Discusión: El no reconocimiento conduce a la imposibilidad del ejercicio de la ciudadanía de la salud; sus mecanismos parten de procesos de socialización desde sus constructos sociohistóricos que se ven reforzados por el modelo médico hegemónico y el campo médico generando tensión entre las lógicas prácticas de médicas(os) y las necesidades de las víctimas. Sin embargo, se observa una fractura de dicho modelo como una posibilidad de transformación hacia un cuidado comprensivo.
PREVALENCE OF CERVICAL PAIN IN ADULTS IN THE CITY OF ARACAJU, SERGIPE, BRAZIL
Authors: Andrade Isaura Nicole Macêdo Cruz De , Antunes Mateus Dias , Souza Ingred Merllin Batista De , Leal Paulo Rogério Cortêz , Marques Amélia Pasqual
Published: March 2024

ABSTRACT Objective: To estimate the current and last 12-month prevalence of cervical pain (CP) in adults in Aracaju, Sergipe, Brazil. Method: Cross-sectional study with 242 adults aged between 18 and 59 living in urban areas. Sociodemographic data, one-time and 12-month CD prevalence, pain intensity assessed using the Numerical Pain Scale, and functional limitation using the Neck Disability Index were evaluated. Results: The prevalence of punctual CD at the interview was 27.7%, while 66.1% had felt pain in the last 12 months. Of the people who felt punctual CP at the time of the interview, the mean pain intensity was 6±4.76, and 82% had a functional disability (mild, moderate, or severe). Conclusion: The prevalence of punctual CD in the last 12 months was high among adults, pain intensity was moderate, and functional disability was mild. Our results demonstrate that the prevalence of cervical pain in adults is high and can influence several aspects of a person’s life. Level of Evidence IV; Observational, Randomized and Cross-Sectional Study.
Complementary feeding indicators from the World Health Organization and the Ministry of Health: agreement analysis and comparison of estimated prevalence in a cohort of children in southwestern Bahia, Brazil, 2018
Authors: Barbosa Clessiane de Brito , Magalhães Elma Izze da Silva , Rocha Daniela da Silva
Published: March 2024

ABSTRACT Objective To assess the agreement between complementary feeding indicators established by the World Health Organization (WHO) and the Ministry of Health (MOH) and to compare the prevalence of these indicators in the first year of a child’s life. Methods : This was a cross-sectional study in a cohort of 286 children from Vitória da Conquista, state of Bahia, Brazil; agreement between indicators and comparison between prevalences were analyzed using the Kappa coefficient and McNemar’s test; the prevalence of the indicators “introduction of complementary feeding” (ICF), “minimum dietary diversity” (MDD), “minimum meal frequency” (MMF) and “minimum acceptable diet” (MAD) were calculated. Results : Three indicators showed poor agreement, with only one demonstrating moderate agreement; prevalence of WHO indicators was higher than that of the MOH (ICF, 94.3% vs. 20.7%; MDD, 75.2% vs. 50.7%; MMF, 97.2% vs. 44.8%; MAD, 96.8% vs. 26.9%). Conclusion The majority of indicators showed poor agreement and the prevalence of WHO indicators exceeded that of the Ministry of Health.
A PRODUÇÃO DE GRAMÁTICAS PEDAGÓGICAS PARA LÍNGUAS INDÍGENAS: A EXPERIÊNCIA COM A LÍNGUA HALITI-PARESI
Authors: Jesus Edinaldo Costa de , Brandão Ana Paula Barros , Kezomae Angelo , Zezokiware Jurandir , Oliveira Elizandra Jéssica Silva
Published: March 2024

Os materiais didáticos em línguas indígenas são uma demanda dos professores e escolas. Não somente a importância de tê-los para o ensino da língua, mas aumentar as possibilidades da cultura escrita e consequentemente o fortalecimento da Língua. A Gramática Pedagógica é um material didático para fortalecimento linguístico, para auxiliar professores no ensino da Língua. Requer um trabalho colaborativo feito por linguistas e professores falantes de sua Língua Materna. Levando também a prática da docência indígena e ampliar e desenvolver a reflexão metalinguística na Língua Haliti-Paresi. Neste artigo iremos apresentar os resultados do subprojeto da Gramática Haliti-Paresi, que está vinculado ao projeto de pesquisa “Salvaguarda do Patrimônio Linguístico e Cultural de Povos Indígenas Transfronteiriços e de Recente Contato na Região Amazônica” com foco no Desenvolvimento de Gramáticas Pedagógicas para Línguas Indígenas do Museu do Índio (Projeto 914BRZ4019). Consideramos as experiências obtidas, as dificuldades e as expectativas da implementação desse material didático. Ressaltando, principalmente, o trabalho colaborativo entre indígenas e linguistas, representando uma nova era e protagonismo dos Povos Indígenas. Com base no que apresentamos, possibilitar que a metodologia de ensino de língua das Gramáticas Pedagógicas, possa ser preponderante para a produção de um material didático. O material demonstrou grande potencial se aliarmos o aspecto cultural, que evidencia uma experiência de ensino mais próxima da cultura oral. Tornando o material mais didático e representado a as situações de comunicação linguística que estão presentes na realidade de vida de um Povo.
A Taxonomic Revision of the Argyrolobium robustum and A. transvaalense Groups (Fabaceae) in Southern Africa
Authors: le Roux M. Marianne , Boatwright James S.
Published: March 2024

Abstract— Previous studies on the genus Argyrolobium (Genisteae, Fabaceae) in southern Africa recognized a group of species defined by a suffrutescent habit, monomorphic flowers and leaves, and the plants not turning black when dried as ‘section A. transvaalense.’
A formal rank was never published for this group. Here a taxonomic study of this group is conducted, including comprehensive descriptions and a key to the species, nomenclature, typifications, diagnostic characters, and geographical distribution. Based on an assessment of morphological characters,
two groups can be recognised: 1) the A. robustum group that comprises four species with a herbaceous habit with up to 55-flowered inflorescences, flowers drying black or turning black when damaged, keel petals lacking pockets, and staminal sheaths fully open above, and 2) the A.
transvaalense group comprising five species with a suffruticose habit with up to 24-flowered inflorescences, flowers becoming discoloured (darker coloured or brown) when dried, keel petals with pockets except in A. megarhizum, and staminal sheaths variously fused into a closed tube.
A Phylogenetic Analysis of Marcetia (Melastomataceae, Marcetieae) and Three New Sprawling Species from Bahia, Brazil
Authors: Pacifico Ricardo , Almeda Frank , Kriebel Ricardo
Published: March 2024

Abstract— Three new species of the Neotropical genus Marcetia are described and illustrated: Marcetia barbadensis, Marcetia minima, and Marcetia serratifolia. The three species are known from small isolated populations
in mountains of the Chapada Diamantina, Bahia, Brazil. The recognition of Marcetia barbadensis and Marcetia serratifolia is confirmed with an updated molecular phylogeny of the tribe Marcetieae (based on ETS, ITS, accD-psaI, atpF-atpH, trnS-trnG, psbK-psbL,
ndhF and rbcL), and by morphological and morphometric studies. In turn, the recognition of Marcetia minima, a new species known only from the type gathering collected about 30 yr ago, is based on analyses of leaf and anther connective shape, as well as linear
measurements of vegetative and reproductive structures. Based on the new phylogenetic hypothesis for Marcetieae, we reconstructed the evolution of habit and petal color in the tribe, and showed that prostrate plants and white flowers evolved repeatedly from ancestors with an erect habit and
pink to magenta petals. We also provide notes on the intergeneric relationships and phylogeny of Marcetia and evaluate the generic placement of the recently described Acisanthera saxatilis.
Diversity of marine benthic species of Nostocales (Cyanobacteria) in Veracruz, Mexico
Authors: Cabrera-Becerril Ernesto , García-García Annie May Ek , Núñez Resendiz María Luisa , Dreckmann Kurt M. , Sentíes Abel
Published: March 2024

Background: Nostocales is a widely distributed, monophyletic order of cyanobacteria, whose species are mainly characterized by the presence of specialized structures such as heterocytes and akinetes. Despite being the most diverse group in marine environments, little is known about coastal species in Mexico. Particularly in Veracruz, only 17 species have been recorded, without photographic, morphological references, or ecological data; these records are only mentioned in floristic lists.
Questions and / or Hypotheses: The present study aimed to contribute to the knowledge of the diversity of benthic marine Nostocales species in Veracruz, Mexico, as well as to provide detailed descriptions and illustrations of the species found, which can serve as a reference in subsequent studies.
Study site and dates: Collect of cyanobacterial growths were made in three locations throughout Veracruz in 2020.
Methods: The organisms were isolated from the field material. With the use of specialized taxonomic keys, they were morphologically identified, described and photographed.
Results: A total of 20 Nostocales species were obtained, of which 17 were additions to the phycoflora of Veracruz, constituting an increase of 55 %. Taxonomic notes are added highlighting their differences with the literature. One of the species was identified as cf. and seven as sp., because their characteristics fully coincided with the generic morphology, but did not completely concur with the literature.
Conclusions: These suggest that several records could correspond to new taxon not yet described that must be confirmed with different molecular markers.
HRVATSKE PJESNIČKE PRAKSE 2000. – 2010.
Authors: Šalat Davor
Published: March 2024

U radu se nastojalo analizirati, opisati i ustanoviti karakter pjesničke scene nultih godina, dominantne tendencije njezine pjesničke prakse i teorije te paradigmatske autore i njihove poetike. Tijekom analize u nultima objavljenih antologija i teorijskih tekstova, središnjega časopisa za poeziju "Poezija" te pjesama desetero paradigmatskih pjesnikinja i pjesnika došlo se do zaključka da u cjelini nultih godina nije bilo dominantne poetike. Donekle se ipak, samo u prvoj polovici desetljeća, uspjela istaknuti takozvana stvarnosna poezija. No upravo je promptna i široka reakcija kritike, kao i pjesničke prakse, na dominaciju te poetike omogućila da se pjesnička scena sagleda u svoj širini poetičke i generacijske raznovrsnosti i vrijednosti. Zaključeno je i da je najvažniju ulogu u osvještavanju pluralizma u hrvatskome pjesništvu i njezinoj teoriji imalo nekoliko antologija te poezije, teorijski tekstovi objavljeni u njima i izvan njih, intenzivna kritička djelatnost, kao i časopis "Poezija". Njegova uređivačka politika osvještavala je pluralizam pjesničke i teorijske scene, ali ga i programatski poticala doprinosom pjesnika i teoretičara svih tada djelatnih naraštaja. Zaključeno je i da je, tematizirajući pjesnike generacije devedesetih, nekoliko teoretičara i kritičara tematiziralo i poeziju koja je nastajala nultih godina te da njihove deskripcije i tipologije u vezi s devedesetima uglavnom vrijede i za pjesništvo nultih. A u ovome se radu pjesničkoj sceni nultih pristupilo induktivnom metodologijom – detaljnim ocrtavanjem teorijskoga konteksta, analizom poezije desetero paradigmatskih pjesnika te, na kraju, izvođenjem općenitijih zaključaka o cijelome promatranom razdoblju. Uočilo se da se među poetikama razmatranih pjesnika samo manji broj može uvrstiti u neki određeni tip pjesništva, a da je između njih čitav spektar hibridnih, kompozitnih poetika koje ne pripadaju bilo kojoj "čistoj" poetičkoj profilaciji. Na temelju toga moglo se zaključiti da su na pjesničkoj sceni nultih godina prevladavale kompozitne poetike s osebujnom kombinacijom poetičkih odrednica kod svakoga pojedinog važnijeg pjesnika, da su te poetike ukupno ocrtale iznimno složen poetski i poetički krajolik te da su se, upravo na toj poetičkoj složenosti, razvili iznimno vrijedni i originalni pjesnički glasovi.
Urban demographic expansion and environmental sustainability of the district of New Chimbote – Ancash – Peru, 2023
Authors: Unyén Kuzma Víctor Bratzo
Published: March 2024

The objective of the research was to determine the % impact of urban demographic expansion on environmental sustainability in Nuevo Chimbote, for the research, the district was divided into two zones, consolidated and expansion, the method used was observational and the experimental design was descriptive-relational, to estimate the sample size, the mathematical model for a finite population with categorical variables was used. The sampling was two-stage, to collect data, the observational and documentary techniques were used, in the latter the questionnaire and the interview guide were used as instruments, validated by experts, then the statistical analysis was done to check the relationship between the variables. The migratory dynamic brings with it the appearance of new towns as a consequence of invasions, generating deficiencies in basic services, overcrowding, an increase in household and construction waste, the loss of green areas, and biodiversity, adding the scarce environmental culture, the lack of treatment of household waste, the non-reuse of construction waste and disorganized population growth. It is concluded that urban demographic expansion negatively affects the environmental sustainability of the district, which according to the statistical analysis showed a value of p < 0.05.
Application of the Pmbok for waste management in markets, Case: Central Market of Trujillo
Authors: Cruzado Carolina
Published: March 2024

In this thesis, the design of a waste management manual is proposed, applying the standard guidelines of the Pmbok Sixth Edition, taking the Central Market of Trujillo as a case study. Given the lack of intervention of the actors involved, the little control, and little awareness in relation to the management of waste management in this establishment, it was considered pertinent to contemplate a project proposal that minimizes the threats that the current one represents for the environment inadequate management of solid waste in said market. In addition, it is considered that this applied research will serve as a background for future research that needs to improve solid waste management in supply centers, and that requires providing a solution to the problem generated by incorrect waste management; in this way, the project constitutes a pilot plan that could be applied in similar facilities throughout the region.
Removal of ibuprofen and amoxicillin in domestic wastewater using activated carbon soaps and moringa seed powder at the laboratory level
Authors: Paredes José L. , Evangelista Guillermo D.
Published: March 2024

This research was done to determine the effect of using soaps with activated carbon and moringa seed powder on the concentration of ibuprofen and amoxicillin in domestic wastewater. The soaps were prepared with transparent commercial glycerin, adding the adsorbents at a rate of 0.1 g/g of soap. The residual water was prepared in the laboratory and characterized, then ibuprofen and amoxicillin were added at a concentration of 3 mg/L each. In the experiments, the soaps were added individually and combined to 1 liter of residual water, in three weight percentages: 5%, 15% and 25%. The combined application of soap with activated charcoal and 25% moringa seed powder was the best treatment with removal of 81.33% and 80% of ibuprofen and amoxicillin, respectively. This treatment was applied to actual domestic wastewater from the wastewater outlet to the Huallaga River in Tingo María-Huánuco-Perú, which was characterized and 72.3% and 69.7% of ibuprofen and amoxicillin were removed, respectively. Through a Tukey test, it was verified that there is a significant difference with a confidence interval of 95%, between the treatments applied in a real residual water and an artificial one.
MONOSODYUM GLUTAMAT İLE İNDÜKLENMİŞ HİPOKAMPAL HASARDA OMEGA-3 YAĞ ASİTLERİNİN KORUYUCU ETKİSİNİN İNCELENMESİ
Authors: YESİL SARSMAZ Hayrunnisa , GÜRGEN Seren Gülşen
Published: March 2024

Amaç

Monosodyum glutamat (MSG) birçok hazır besinin

içine katılan ve beyinde nöronlar üzerine eksitotoksik

olduğu bilinen lezzet arttırıcıdır. Çalışmanın amacı

çocukluk dönemindeki ratların hippokampus bölgelerindeki

nöronlarda, MSG’nın olası toksik etkisine karşı

eikosapentaenoik asit (EPA) ve beyin gelişiminde

etkili olan dokosaheksaenoik asit (DHA)’in koruyucu

etkilerine rağmen beyinde oluşan nöral hasarın immünohistokimyasal

incelenmesidir.

Gereç ve Yöntem

Her bir grupta çocukluk döneminde olan 4 haftalık,

170-205 gr ağırlığında 6 adet, toplam 24 Wistar

albino dişi ratlar kullanılacaktır.

1. Grup: Kontrol grubu (0,9 % saline solution 1.3.5.7.9.

günler subcutan (sc) verildi,

2. Grup: MSG uygulanan (4 mg/g 1.3.5.7.9. günler

sc),

3. Grup: MSG + EPA uygulanan (4 mg/g 1.3.5.7.9.

günler sc + 300 mg/kg 9 gün oral),

4. Grup: MSG + DHA uygulanan (4 mg/g 1.3.5.7.9.

günler sc + 300 mg/kg 9 günler oral), 9. Günün sonunda

beyin dokularının hipokampus CA1 bölgesinde

immünohistokimya ve TUNEL tekniği uygulaması için

%10 luk nötral formalin içine alınacaktır.

Bulgular

Çocukluk dönemindeki dişi ratların beyinlerinin hippokampüs

CA1 bölgesi incelendiğinde, S100β immunoreaktivitesi

MSG grubunda diğer gruplara göre kuvvetli

ve anlamlı reaksiyon gösterdi (p=0,000). MSG+EPA

ve MSG+DHA grupları arasında fark anlamsız olduğu

izlendi (p
PARKİNSON HASTALIĞI İLE TIRAP GEN POLİMORFİZMİ ARASINDAKİ İLİŞKİNİN ARAŞTIRILMASI
Authors: KIR KAYAN Merve , ŞAHİN CALAPOĞLU Nilüfer
Published: March 2024

Amaç

Parkinson hastalığı (PH), beyinde dopamin üreten

hücrelerin kaybıyla ilerleyen bir hastalıktır. PH’li hastaların

beyin dokularında α-sinüklein adlı bir protein

birikir ve nöroinflamasyona neden olur. Nöroinflamasyon,

beyindeki bağışıklık sistemi hücrelerinin aktivasyonu

ve iltihaplanma ile ilgili moleküllerin salınımını

içerir. Bu süreçte rol oynayan Toll Like Reseptör

(TLR)’ler patojenleri ve hasarlı hücreleri tanıyarak

bağışıklık yanıtını başlatır. Bu çalışmada, TLR sinyal

yolağında yer alan bir adaptör protein olan Toll/IL-1

reseptör ilişkili protein (TIRAP) gen bölgesi üzerindeki

polimorfik allelin PH’li hastalarda ve kontrol grubunda

karşılaştırmalı olarak ilişkisini araştırmayı amaçladık.

Gereç ve Yöntem

Çalışmaya 39 PH hastası ve 40 sağlıklı kişi katıldı.

Katılımcılardan kan örnekleri alınarak DNA izolasyonu

yapıldı. TIRAP rs8177374 (975C/T) polimorfizmi

PCR ve RFLP yöntemleri ile belirlendi.

Bulgular

T allel frekansı PH hastalarında 0,218; kontrol grubunda

ise 0,200 olarak bulundu. C allel frekansı ve

CC genotip frekansı her iki grupta da yüksek bulundu.

F değeri PH hastalarında 0,128; kontrol grubunda

ise 0,250 olarak bulundu. OR değeri 1,115; CI değeri

ise [0,517-2,402] olarak bulundu. Total OR=1,508;

P=0,758 olarak bulundu.

Sonuç

TIRAP polimorfizmi ile PH arasında istatistiksel olarak

anlamlı bir ilişki bulunmadı. TIRAP polimorfizminin PH

hastalarında risk faktörü olmadığı sonucuna varıldı.
YENİ NESİL BİLGİSAYAR DESTEKLİ SİMÜLASYON MAKETİNDE KARDİYOPULMONER RESÜSİTASYON EĞİTİMİNİN ASİSTAN EĞİTİMİNDEKİ ETKİNLİĞİ
Authors: ÖZDEN Eyyüp Sabri , ÖZCAN Mustafa Soner , KARABACAK Pınar , KAPLAN Burcu , ALKAYA Filiz , KIRDEMİR Pakize
Published: March 2024

Amaç

Kardiyopulmoner resüsitasyon (KPR) uygulamalarında,

lisans ve lisansüstü tıp eğitiminde simülasyon

teknolojisi kullanımı giderek artmaktadır. Sürekli eğitimin

bir parçası olan resüsitasyon eğitiminde yeni nesil

bilgisayar destekli simülasyon maketi (YNBDSM)

kullanımı ile asistanların bilgi düzeylerinin gelişimi

araştırıldı.

Gereç ve Yöntem

Eğitime 21 klinikten 192 asistan çağrıldı. Toplam 125

asistan eğitime katıldı. 10 kişilik gruplar halinde toplam

3 makette 3 eğitimci ile 2 saat süre ile KPR eğitimi

verildi. Eğitim öncesi katılımcılara 50 soruluk doğru/

yanlış testi yapıldı. 100 puan üzerinden değerlendirildi.

2 saatlik uygulamada asistanlar birebir YNBDSM

üzerinde havayolu açma manevraları, solunum, kompresyon

ve defibrilasyon gibi resüsitasyon aşamalarını

uyguladı. Tüm asistanlar YNBDSM tabletinde

uygun kompresyon derinliğini gösteren gösterge ile

hastaya etkin kompresyon yapıldığı anlaşılarak resüsitasyonu

uyguladı. Maketin monitöründe şoklanabilir

ve şoklanamaz tüm ritimler gösterilerek, senaryolar

oluşturularak ileri yaşam desteği algoritması uygulandı.

Eğitim sonrası katılımcılara aynı doğru/yanlış testi

verildi. İlk ve son test karşılaştırması cinsiyet, klinik ve

asistan eğitim yıllarına göre yapıldı.

Bulgular

Resüsitasyon öncesi test (RÖT) ve resüsitasyon sonrası

test (RST) puanlarının karşılaştırılmasında anlamlı

farklılık gözlenmiştir. 0-1 yıl, 2-3 yıl ve 3 yıldan

fazla çalışanlarda RÖT ve RST puanları arasında istatistik

olarak anlamlı farklılık gözlendi. RÖT ile RST

puanları ve RST ile RÖT-RST farkı arasında istatistik

olarak anlamlı pozitif bir korelasyon, RÖT ile RÖTRST

farkı arasında istatistik olarak anlamlı negatif korelasyon

tespit edilmiştir.

Sonuç

Çalışmalarda resüsitasyon eğitiminde simülasyonun

kullanılması eğitim sonuçlarını iyileştirdiği, resüsitasyon

yönergelerine daha iyi uyum sağlandığı gösterilmiştir.

Yeni nesil bilgisayar destekli simülasyon maketinde

asistanların görerek ve uygulayarak yaptığı KPR

eğitiminin bilgi düzeylerini geliştirmede etkin olduğu

kanısındayız.
THE EFFECT OF VOLUME STATUS ON QUALITY OF LIFE, ANXIETY, DEPRESSION AND SLEEP QUALITY IN HEMODIALYSIS PATIENTS
Authors: ÇELİKDELEN Selma Özlem
Published: March 2024

Objectives

To determine the volume status of patients undergoing

hemodialysis using the bioimpedance method and to

investigate the relationship of volume status with the

patients’ quality of life, anxiety, depression, and sleep

quality.

Material and Method

This cross-sectional study included a total of 100

patients undergoing hemodialysis at the Hemodialysis

Unit in March 2016. The volume status of the patients

was determined using bioelectrical impedance

analysis (BIA) performed with a body composition

monitor before their mid-week hemodialysis sessions.

The quality of life was evaluated using the 36-item

Short Form Survey, sleep quality was assessed using

the Pittsburg Sleep Quality Index (PSQI), depression

screening was performed with the Beck Depression

Inventory, and anxiety screening was undertaken with

the Beck Anxiety Inventory. The patients were divided

into three groups according to the extracellular fluid/

total body fluid (ECF/TBF) ratio, which is one of the

BIA parameters: Group 1,
ÇOCUKLUK DÖNEMİNDE ANAFİLAKSİ: TEK MERKEZ DENEYİMİ
Authors: MASLAK İbrahim Cemal
Published: March 2024

Amaç

Anafilaksi ani başlangıçlı, hayatı tehdit eden, sistemik

alerjik bir reaksiyondur. Bu çalışmada anafilaksi tanısı

ile takip ettiğimiz olguların demografik özelliklerini,

klinik bulgularını, anafilaksi tetikleyicilerini ve ilk basamak

tedavide adrenalin kullanım durumunu değerlendirmeyi

amaçladık.

Gereç ve Yöntem

Mayıs 2021- Ekim 2023 tarihleri arasında çocuk alerji

bölümünde anafilaksi tanısı ile takip edilen 0-18 yaş

arasındaki hastalar incelendi. Anafilaksi tanısı alan

olguların demografik özellikleri ve anafilaksi tanı ve

tedavi kayıt bilgileri değerlendirildi.

Bulgular

Toplam 46 anafilaksi hastası değerlendirildi. Hastaların

28’i (%61) erkek olup, ortanca yaş 3,5 (ÇAU: 1-10)

yıl idi. Tüm yaş gruplarında en sık 3 tetikleyici sırasıyla

besin (%61), ilaç (%20) ve böcek zehiri (%20)

idi. Süt, besinler içinde anafilaksiden en çok sorumlu

tetikleyici idi (%22). Olguların %28’ i ağır anafilaksi tanısı

ile takip ediliyordu. Birinci basamak tedavisinde

adrenalin kullanım oranı %52 idi.

Sonuç

Besinler erken çocukluk döneminde anafilaksiden en

çok sorumlu olan tetikleyicilerdir. İlk başvuruda adrenalin

kullanım oranı oldukça düşüktür. Anafilaksi tanı

ve tedavisine yönelik tüm sağlık çalışanlarına yönelik

eğitim programları verilmelidir.
Las unidades de integración de TIC para la educación en las universidades colombianas
Authors: Paz Saavedra Luis Eduardo , Beneth Benavides Jenifer Andrea
Published: March 2024

La transformación digital presentada en las universidades en las últimas décadas, ha hecho que estas instituciones busquen alternativas para promover el uso y apropiación de tecnologías digitales por parte de profesores y estudiantes. Para este propósito, una estrategia implementada en muchas instituciones ha sido la creación de unidades de integración de estas tecnologías en la educación, buscando favorecer los procesos de enseñanza y aprendizaje. En este contexto, el presente estudio tiene como objetivo analizar las funciones que cumplen dichas unidades, haciendo un análisis en las 88 universidades colombianas. La metodología utilizada es el análisis de contenido, usando como fuente de información el sitio web oficial de cada universidad. Los resultados indican que existe información de 30 unidades que cumplen funciones relacionadas con capacitaciones en temas de tecnología educativa, gestión de repositorios de recursos educativos digitales y administración de plataformas de aprendizaje, entre otras. En las conclusiones y la discusión se analiza la forma en que las universidades pueden fortalecer la labor de estas unidades con miras a contribuir a los procesos de transformación digital e innovación educativa con el uso de estas tecnologías.
Bulk RNA sequencing v1
Authors: not provided anita.adami
Published: March 2024

This protocol describes how to perform bulk RNA sequencing
Isolation of NeuN+ cells from brain tissue (for CUT and RUN) v1
Authors: not provided anita.adami
Published: March 2024

This protocol describes the steps to isolate NeuN+ cells from brain tissue in preparation for CUT and RUN
Preparation for OCT embedding Mouse Kidney Tissue (TDA-University of Washington) v1
Authors: not provided kangsk , Dong Runze , Gu Liangcai
Published: March 2024

Preparation for OCT embedding Mouse Kidney Tissue (TDA-University of Washington)
Exp02 v1
Authors: Medina Cárdenas Mayleth
Published: March 2024

En este experimento se buscó analizar el cambio de la temperatura del agua con respecto a la ley cero de la termodinámica, de acuerdo al equilibrio térmico. Se planteó la posibilidad de una variación en el cambio de temperatura por el color del recipiente. Para corroborar dicha teoría, se realizó un experimento donde se colocó agua a tres termos exactamente iguales, pero de distinto color (negro, blanco y plateado) y con ayuda de un arduino uno y sensores de temperatura, se registraron los cambios de temperatura con respecto al tiempo de cada uno de los termos. También, se generó un modelo matemático a prueba y error que concordara lo mejor posible con las mediciones obtenidas. Se generó una gráfica que muestra la temperatura de cada uno de los termos con respecto al tiempo y este modelo para una comparación de estos. Finalmente, puede observarse un cambio en temperatura más lento dentro del termo blanco mientras que las del negro y el plateado son más similares. Asimismo, se calculó la potencia de cada uno de estos donde podemos apreciar que la del termo negro es menor que las otras dos.
Co-Production for Equitable Governance in Community Climate Adaptation: Neighborhood Resilience in Houston, Texas
Authors: Munenzon Dalia
Published: March 2024

As urban areas grapple with the pressing impacts of climate change, fostering community-level resilience becomes imperative. Co-production, emphasizing active stakeholder engagement, offers a pathway to robust, equitable, and inclusive adaptation strategies. This article delves into the co-production processes within neighborhood resilience planning in Houston, Texas, revealing how collaboration between communities, planners, and municipal leaders can address climate vulnerabilities and support disadvantaged groups. Through an empirical analysis of three Houston neighborhoods, the study evaluates co-production’s role in promoting neighborhood-scale adaptive capacity and reshaping power dynamics to advance equity and environmental justice. The results highlight the significance of local institutions and the necessity of municipal commitment to co-production efforts. The study contributes actionable insights on the application of co-production in neighborhood climate adaptation, emphasizing the need for direct municipal engagement to implement transformative spatial projects and rebalance governance frameworks for effective climate action.
Elastomeric impression materials used in modern orthopedic dentistry
Authors: Bordina Galina E. , Lopina Nadezhda P. , Andreev Alexey A.
Published: March 2024

This article presents a review of elastomeric impression materials currently used in orthopedic dentistry. The elastomer group is divided into silicone, polyester, and thiocol (polysulfide) materials. Silicone impression materials are widely used in orthopedic dentistry. Their structural basis is polymethylsiloxane with active terminal hydroxyl groups. Polyester materials consist of the main and catalyst components (pastes). The main component contains a polymer with imine groups, fillers, and plasticizers. Sulfonic acid ester is present in the catalyst paste. When these two components are mixed, ionic (cationic) polymerization occurs. Polysulfide materials are produced as base and catalyst pastes. The structural unit of the main paste is polysulfide or mercaptan rubber, and the catalyst paste acts as an oxidizer. Lead dioxide is often used as an oxidizer. The resulting polymer does not have a stereoregular structure, which causes its stickiness. It is technologically challenging to obtain a polymer with a stereoregular structure.
When theoretically comparing the listed types of elastomeric impression materials, according to their properties, chemical composition, advantages, and disadvantages, polyester and polysulfide impression materials can be distinguished as more advanced. Silicone materials have disadvantages; however, they are often used for domestic dentistry owing to the presence of domestic manufacturers and relatively low cost.
The Heads of Ara-Gaya Based on Wooden Framed Structure Installed Graves
Authors:   Korean Ancient Historical Society, Yeo Chang-hyun
Published: March 2024

This article focused on the wooden structure tombs identified in the Ancient Tombs in Marisan Mountain, the central tomb of Aragaya, to understand the space occupancy method of the wooden structure tombs, the meaning of the material culture contained in the prestige, and the burial site, and to find out how the hierarchy of the subject appears. In addition, the newly identified wooden structure tombs around Aragaya were reviewed and the interaction between the heads of the Ancient Tombs in Marisan Mountain and the heads of each site was also examined.
Wooden structural tombs can be classified into I and II types, and each type has a difference in hierarchy depending on the size of the burial subject, the prestige, and the properties of the burial subject. It could be presumed that the hierarchy among the heads reflected not only the hierarchy assigned to each head, but also the functions and roles. In addition, depending on the group to which each head belongs, a certain space occupation method within the tomb appears, and through this, the ‘showscape’ of the horse mountain tomb was completed. In particular, the heads and mausoleums involved in the wooden structure tombs in the Ancient Tombs in Marisan Mountain were able to assume interactions with the heads of the burial site who accepted the wooden structure tombs in the area around Haman. The construction technology of high-rise tombs such as high rock, embankment method, and partitioned stonework in the wooden structure tombs around Haman was understood as the result of the direct impact of the interaction between the construction groups beyond simple exchanges between the heads.
The Regeneration of Mongchontoseong in 5-6th Century AD: After Goguryeo’s Southward Expansion and Hanseong Baekje‘s Decline
Authors:   Korean Ancient Historical Society, Hong Seungyeon
Published: March 2024

This paper aims to examine the processs of regeneration of Mongchontoseong by Goguryeo, following Baekje’s relocation of its capital to Ungjin. Drawing upon the artifacts from 1980s excavation and the recent fieldwork findings, this study explores the spatial and temporal reorganization in the Mongchontoseong after 5th century AD.
The spatial distribution of the pottery from the southern part of the inner Mongchontoseong site was first explored. Goguryeo strategically reused places previously built by Baekje, including storage, ponds, and pits, and also altered the built environment. The features, iron weapons, farming tools, and pottery type also reveal the diverse aspects of the long-term occupation of Goguryeo, taking the roles of domestic housing, rituals, agricultural activities, and storage. The radiocarbon dating results from the pits and roadways show Goguryeo’s active engagement in infrastructure reconstruction from the late 5th century to the middle of the 6th century, predating the reoccupation by the allied forces of Baekje and Silla in 550 AD. The material evidence reveals Goguryeo’s prolonged regeneration of the site for the southward expansion, as sociopolitical strategies in the context of warfare in the Korean Peninsula during 5-6th century AD.
Background of the Early Politics in Yeongnam and the Structure of Saroguk
Authors:   Korean Ancient Historical Society, Jang Kimyeong
Published: March 2024

Through the long-distance trade network and ritual structures of base settlements that were intensively developed in the Yeongnam region in the 2nd century BC, the background of the establishment of the early politics and the method of solidarity were examined. Long-distance trade beyond the Yeongnam region is concentrated in the 2nd century BC, and the bases where foreign trade is active overlap with regions(mainly Daegu, Gyeongsan, and Gyeongju) found in the early days of the clustering of wooden tombs. In some regions, politics that internally united regional units appeared in order to form a socio- economic coalition suitable for logistics distribution, redistribution, cost reduction, and information solidarity amid intensively developed foreign trade in the 2nd century BC. Thus, it is inferred that the clustering of wooden tombs appeared from the time when these early politics reached villages and townships as local political bodies to maintain active foreign trade, iron production, and distribution.
In this situation, by linking topographic conditions, traffic routes and literature records, and archaeological data, focusing on Saro-guk, the composition of the euprak and the structure of the country were explained. Around the middle of the 2nd century BC, it is expected that the early Saroguk was established, and it is interpreted that the 6 villages, symbolized as major towns and villages, were united through the conference. Early Saroguk is a device that binds and maintains local communities while showing various forms for each town and village, and the phenomenon of establishing altar-style stone tombs, high- altitude enclosure, standing-ritual structures, and early wooden tombs by base is similar. In addition, the title of ChaChawoong, which was mentioned in early literature records, also weighed on the ideological and religious power base. Given the ritual structure of the settlement base and the power base of the early ruler, it was difficult to sustain the national structure only by pursuing the interests of foreign trade, and it is assumed that even by transforming the traditionally important megalithic monuments and high-altitude enclosure, it led to community cohesion.
Trauma-Informed Music Therapy: Theory and Practice, edited by Laura E. Beer and Jacqueline C. Birnbaum
Authors: Dalton Andrea
Published: March 2024

Book review for Trauma-Informed Music Therapy: Theory and Practice as solicited by Virginia Driscoll
Exploring the Distribution of Phylogenetic Networks Generated Under a Birth-Death-Hybridization Process
Authors: Justison Joshua A. , Heath Tracy A.
Published: March 2024

Gene-flow processes such as hybridization and introgression play important roles in shaping diversity across the tree of life. Recent studies extending birth-death models have made it possible to investigate patterns of reticulation in a macroevolutionary context. These models allow for different macroevolutionary patterns of gene flow events that can either add, maintain, or remove lineages—with the gene flow itself possibly being dependent on the relatedness between species—thus creating complex diversification scenarios. Further, many reticulate phylogenetic inference methods assume specific reticulation structures or phylogenies belonging to certain network classes. However, the distributions of phylogenetic networks under reticulate birth-death processes are poorly characterized, and it is unknown whether they violate common methodological assumptions. We use simulation techniques to explore phylogenetic network space under a birth-death-hybridization process where the hybridization rate can have a linear dependence on genetic distance. Specifically, we measured the number of lineages through time and role of hybridization in diversification along with the proportion of phylogenetic networks that belong to commonly used network classes (e.g., tree-child, tree-based, or level-1 networks). We find that the growth of phylogenetic networks and class membership are largely affected by assumptions about macroevolutionary patterns of gene flow. In accordance with previous studies, a lower proportion of networks belonged to these classes based on type and density of reticulate events. However, under a birth-death-hybridization process, these factors form an antagonistic relationship; the type of reticulation events that cause high membership proportions also lead to the highest reticulation density, consequently lowering the overall proportion of phylogenies in some classes. Further, we observed that genetic distance–dependent gene flow and incomplete sampling increase the proportion of class membership, primarily due to having fewer reticulate events. Our results can inform studies if their biological expectations of gene flow are associated with evolutionary histories that satisfy the assumptions of current methodology and aid in finding phylogenetic classes that are relevant for methods development.
Boreout Syndrome in Managers: A Qualitative Study on Antecedents-Consequences and Solution Suggestions
Authors: DEMİR Filiz
Published: March 2024

Aim of the research is to reveal the antecedents and consequences of boreout syndrome in managers and to develop solution suggestions. In this context, a qualitative research was designed and feelings and thoughts of individuals working as managers in Karaman were consulted. The data obtained from the interviews were examined with content and descriptive techniques and analyzed with Maxqda software. As a result, additional antecedents and consequences different from which found in the literature were identified for the factors leading to boreout syndrome in managers. Antecedents were identified as seeing the same faces all the time, working at a desk/indoors, technical disruptions, environmental pressure, and virtuality, while consequences were identified as daydreaming/planning. Finally, a model was developed based on the findings, some theoretical and practical contributions were presented, and recommendations were made.