bluuebunny/crossref_metadata_2025 huggingface dataset:
Hepatopathies of monogastric animals under the conditions of the Northern Trans-Urals
Authors: Krasnolobova E. P. , Sidorova K. A. , Cheremenina N. A.
Published: February 2023

As is known, the liver in the body of mammalian animals converts nutrients into other chemical formations, which are later used by the body itself or are excreted. Also, this organ performs a detoxification function. The liver contains the necessary supply of blood, vitamins and carbohydrates for the animal, as well as the synthesis of some blood proteins and other vital organic substances. It is known that up to 1,000 different biochemical processes take place in this largest gland of the body, however, due to the enormous load on the hepatocyte, it often undergoes destruction. The level and intensity of metabolic processes in the body of animals depends on the morphofunctional state of this organ. The aim of the research was to study the spread and manifestation of hepatopathy in monogastric animals in the conditions of the Northern Trans-Urals. The liver of the studied animals (rabbits and dogs) was selected for morphohistological studies. Based on the conducted studies and analysis of the results obtained, it was found that various types of hepatopathy in rabbits with unbalanced feeding and feeding with substandard feed were observed in 45% of cases, and in dogs - in 41.7% of cases. For the digestive glands, both substandard commercial feed and feed prepared by the owners of animals themselves have a negative impact. At the same time, the degree of liver dysfunction did not depend on whether the animals were fed industrial feed or food "from the table". In the course of our research, the following data were obtained: during morphological examination of the liver of rabbits, pathologies were established in 45% of cases, of which hydropic dystrophy -10%, hepatosis -20%, cirrhosis -15%. Liver dysfunction, as an independent disease, was registered in dogs in 14.1% of cases. In experimental dogs, we treated the following types of liver lesions: 42% - liver steatosis, 24.5% - liver inflammation, 12% - liver cirrhosis, 19.2% - cholecystitis, 2.3% - liver neoplasms.
Experience in the treatment of horses with short incomplete sagittal fractures of the proximal phalanx
Authors: Chernigova S. V. , Suchkov M. V. , Zubkova N. V. , Karklin A. I.
Published: February 2023

Sagittal fractures are the most common injury of the proximal phalanx in horses. Choosing the optimal treatment tactics allows you to eliminate the physiological consequences of injury. The aim of this work was to compare the effectiveness of traditional and surgical methods of treatment of horses with short incomplete sagittal fractures of the putus bone. Thus, the study included horses (n=20) with short incomplete sagittal fractures of the proximal phalanx, which were then divided into two groups. In the first group (n=10), treatment was based on the application of a plaster cast, changing every 14 days. Osteosynthesis by screw fixation was performed in the second experimental group (n=10). Clinical and radiological research methods were used in the work. Complete radiographic healing was confirmed in 100% of animals in the second group, where osteosynthesis was performed by screw fixation, they returned to full athletic load without complications. However, in the first group of horses to which a plaster cast was applied, only 72.7% of animals and 27.3% of horses completely recovered their athletic qualities due to the development of complications, in the form of osteoarthritis changes, were excluded from sports. The proposed method of treating fractures in horses of the second group using the screw fixation method increases the possibility of animals returning to their previous loads. The rehabilitation technique developed and implemented in the clinic expands the possibilities of use in practical veterinary medicine.
The technology of installation of breast implants in the subpectoral space while preservation attachment of the abdominal part of the pectoralis major muscle
Authors: Zelenin V. N. , Zelenin N. V.
Published: February 2023

The paper describes the technology of installing breast implants in the subpectoral cellular space while maintaining the attachment of the abdominal part of the pectoralis major muscle and evaluate the results of its application. A retrospective analysis of the results of primary breast augmentation in 762 patients operated by the authors in 2010–2020 was carried out.

The space for the breast implant was formed following a certain sequence of actions. The boundaries of the receptacle were: inside – the place of attachment of the pectoralis major muscle to the sternum, outside – the abdominal part of the pectoralis major muscle and the pectoral fascia, passing to the bundles of the anterior serratus muscle, at the top – thoracoacromial vascular bundle, below – VI rib and fascial node, formed by the transition of the thoracic fascia and the aponeurosis of the abdominal part of the pectoralis major muscle to the anterior wall of the sheath of the rectus abdominis muscle. Conclusions. 1. The technology of installing implants in the subpectoral cellular space, while maintaining the distal attachment of its abdominal part, allows achieving the stability of the position of the implants and avoiding rotation and malposition of the implants. 2. In terms of up to 3–4 months after surgery, a higher location of implants on the chest is often observed. 3. The decision on the need and degree of mobilization of the abdominal part of the pectoralis major muscle should be made individually. 4. The technique cannot be used when the width of the implant base exceeds the width of the pectoralis major muscle at the level of the IV rib, and, therefore, limits the choice of larger implants.
State of the problem of artificial sphincter formation during colostomy (literature review)
Authors: Korobeynikova V. I. , Dambaev G. Ts. , Avdoshina E. A.
Published: February 2023

Based on the analysis of domestic and foreign literature in the context of comparative effectiveness, the characteristics of the methods for creating an artificial sphincter during colostomy are presented. Various methods of colostomy formation are highlighted. Currently more than 200 methods and modifications of colostomy are known each of which has advantages and disadvantages and therefore cannot be considered ideal. In addition, there is the problem of maintenance of the colostomy associated with the constant functioning of the intestine and accordingly the release of contents. Therefore the search for a solution to the issue of preventing complications of terminal colostomy and improving the technique of forming an artificial anus is a very urgent and far from solved problem of operative coloproctology.
To the blessed memory of Professor Merzlikin Nikolay Vasilievich (16.12.1952–14.11.2022)
Authors: Editorial Article
Published: February 2023

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Isolation, screening and optimization of cellulase production by a novel bacterial isolate Enterococcus durans
Authors: Bhati Nikita , Shreya  , Sharma Arun Kumar
Published: February 2023

Cellulose is an abundant plant biomass and a renewable source of energy in the ecosphere. The breakdown of cellulose occurs via the cellulase enzyme, which is commonly produced by microbes. This study aimed to optimize the fermentation parameters for enhanced cellulase production. Standardized parameters include isolation and screening of cellulase-producing bacteria (CPB), production of an enzyme, biochemical and molecular identification of bacterial isolate, optimization of cultural parameters, and application in wash performance. A total of 581 bacterial strains were isolated from soil samples, of which 16 isolates formed zones of hydrolysis on carboxymethylcellulose (CMC) agar media and were categorized as CPB. Based on maximum hydrolysis zone formation, three isolates, Krishi Vigyan Kendra-5 (KVK-5), Greenhouse-4 (GA-4), and Medicinal Garden-5 (MG-5) were chosen for bacterial cellulase production (BCP), with the isolate MG-5 proving to be the best cellulase producer (1.75 ± 0.01 U ml-1). Based on 16S rRNA gene sequencing the isolate MG-5 was identified as Enterococcus durans. The optimized parameters for the production of the cellulolytic enzyme were an incubation period of 48 h, CMC (carbon source), and yeast extract (nitrogen source) at a concentration of 1.5% w/v, pH 7, 45 °C, 1.5% v/v inoculum size and 100 rpm. Optimum conditions resulted in a 1.92-fold increase (3.36 U ml-1) in cellulase activity. Cellulase enzyme when used with detergent (Surf Excel), resulted in more efficient removal of chocolate stains on cotton fabric. This is the first report of Enterococcus durans producing cellulolytic enzymes. The analysis of cellulase in stain removal provides valuable evidence regarding the application of this enzyme in laundry cleaning.
Unusually elevated CA19.9 with adnexal mass: Does it lead to some conclusions or confusion?
Authors:   All India Institute of Medical Sciences, New Delhi, India., Ray MD
Published: February 2023

Elevated level of CA19.9 is usually associated with malignancies of the hepatobiliary and the pancreatic system. It not only helps to diagnose the malignancy, but also ever high levels can indicate advanced or metastatic diseases [1]. However in rare instances elevated CA19.9 has been found in patients with adnexal masses. This is not only uncommon but also confounding, while trying to ascertain the nature of the ovarian mass and to determine the optimal surgical management in young and premenopausal patients. We would like to report three such cases who had presented with ovarian mass and very high levels of CA 19.9 which led us to diagnostic dilemma and much confusion.
Stercoral ulcer perforation mortality: A rare presentation
Authors:   Department of Surgery, Aga Khan University, Karachi, Pakistan., Khan Sadaf
Published: February 2023

Stercoral ulcers resulting from damage to the intestinal lining due to chronic constipation are rarely presented as perforations. The incidence of these perforations is 3.2% of all colonic perforations. Poor diet, anatomic factors, and certain medications increase the risk of perforations. The presentation of stercoral ulcers varies widely among patients. Immediate surgical intervention is required for these patients because of the increased risk of mortality due to severe intraperitoneal contamination. To the best of our knowledge, we report the first case from our region of patient mortality due to stercoral ulcer perforation.
Left leg swelling: A case of May-Thurner syndrome
Authors:   Department of Internal Medicine, Willis Knighton Health System, USA., Monaco Brian
Published: February 2023

May-Thurner Syndrome is a left common iliac vein thrombosis caused due to its compression by right common iliac artery, an anatomical variant that is underreported. We report the case of a 52 year old female who presented with left leg swelling and was diagnosed with May-Thurner Syndrome. She underwent an iliac vein thrombectomy and was discharged on life-long anticoagulants.
Pengaruh Kemiskinan, Pertumbuhan Ekonomi, dan Pengeluaran Pemerintah Terhadap Islamic Human Development Index (I-HdI) di Indonesia
Authors: Dalimunthe Abd Halim , Imsar Imsar
Published: February 2023

Conventional measurement of economic development is considered not to reflect social justice and does not represent social welfare. Various criticisms and perspectives on measuring economic development have emerged. One of them is the Islamic economic perspective that uses the measurement of human welfare and development through the Islamic Human Development Index or often abbreviated as I-HDI. I-HDI includes elements of social welfare that have often been overlooked. The purpose of this study was to determine the value of I-HDI and the effect of several conventional economic variables on the I-HDI. The variables in question are poverty, economic growth, and government spending. The data used in this study is secondary data derived from the publications of BPS and the World Bank. This research is a descriptive quantitative research. The data used is time series data from 2010-2020. The analysis was performed using multiple linear regression. The results showed that I-HDI Indonesia has increased every year although it is still relatively low. Poverty and economic growth have a negative effect on I-HDI and government spending has a positive effect. So, it can be concluded that human development in Indonesia is still relatively low and one of the factors that can increase this is government spending.
Catálogo florístico. Sitio prioritario Sarco, Región de Atacama. Segunda edición
Authors:   Instituto Forestal (Chile), Hernández Cartes José , Jimenez Rojas Ismael , Montenegro Rojas Jaime , Ibañez Bowne Sergio , Gacitúa Arias Sandra
Published: February 2023

Se ha logrado identificar en el Sitio prioritario Sarco un total de 180 especies vasculares, pertenecientes a 55 familias de las cuales 160 fueron identificadas a nivel específico y 20 a nivel de género. De las 180 especies de plantas vasculares registradas, 2 corresponden a la Clase Gnetopsida, 2 a la Clase Polypodiopsida, 19 a la Clase Liliopsida y 157 a la Clase Magnoliopsida. Todo esto representa el 8% de la flora a nivel nacional. La categoría taxonómica con mayor relevancia en cuanto a diversidad corresponde a la Clase Magnoliopsida con el 87,2% del total de especies registradas, mientras que la Clase Liliopsida representa el 10,6% de la flora del área de estudio. La Clase Gnetopsida presenta un bajo porcentaje, 1,1% del total, mientras que la Clase Polypodiopsida registra el 1,1% de las especies del área de estudio. Se determinó que 113 especies son endémicas de Chile (69%), 36 especies son nativas (22%), 8 especies introducidas (5%), 2 especies son endémicas de la Región de Atacama (1%).
The Deconstruction of Personhood and the Rights-holder/Rights-object Binomial
Authors: Madrid Ramírez Raúl
Published: February 2023

A long-lasting tradition of Western thinking has considered that human nature and the individual are non-historical and self-identical; both represent a fixed and immutable reality, either because they are an expression of transcendence (scholastics) or because they are an end on their own (enlightened). This notion of the human person leads to a concept of dignity that is equally self-identical and expressed in the intrinsic value of a reality whose endpoints are perfectly delineated in a dialectical binary opposition concerning non-personal realities. As a counterpart, the thesis that declares a metaphysical closure denounces the end of that trend, as the former would lay the basis to reshape the personality, replacing the logic of the opposites with the logic of supplement, whose properly deconstructive element lies in the denial of the possibility of foundation. This implies a double destructuring movement: (a) to affirm that some nonhuman reality of the corporeal world is also personal, and (b) to deny that human reality is always and, in any case, personal. This paper aims to explain how this reconfiguration of the notions of “person” and “thing” occurs in current thinking.
Investigation of Life Long Learning Tendencies of Undergraduate Students in Turkey
Authors: Sıvacı Sadık Yüksel , Kılınç Mustafa , Köroğlu Mustafa , Demirel Enes
Published: February 2023

Investigation the lifelong learning tendencies of undergraduate students, who are legally adults, have gained their own learning responsibilities and are expected to strive for continuous self-improvement, is extremely important in terms of adapting to modern life and reaching the most accurate and up-to-date information against the ever-changing and developing information volume. In this context, the aim of the research is to determine the lifelong learning tendency levels of undergraduate students and to examine their lifelong tendencies in terms of various variables. The research is a study in survey model. The study group of the research consists of 2713 undergraduate students studying at Burdur Mehmet Akif Ersoy University in the 2020-2021 academic year. The “Lifelong Learning Tendency Scale” developed by Diker-Coşkun (2009) was used as the data collection tool. According to the results of the research, it was found that undergraduate students had a high level of lifelong learning tendency, and their lifelong learning tendency levels showed significant difference according to the variables of gender, age, grade level, cumulative grade point average, socio-economic level of the family, department and university satisfaction. It was also found that there was no statistically significant difference according to the place of residence variable. According to the findings, suggestions were made for increasing the lifelong learning tendencies of undergraduate students and for new studies.
OPTIMASI BLENDING BIOSOLAR DI PT.AB
Authors: Maromon Piere
Published: February 2023

Biodisel merupakan salah satu produk bahan bakar minyak yang dihasilkan oleh PT.AB. Dengan semakin besarnya kebutuhan biodisel di dalam negeri yang di butuhkan, sehingga dituntut pula untuk meningkatkan produksinya agar dapat memenuhi kebutuhan tersebut. Oleh karena itu sangat diperlukan untuk dapat melaksankan proses blending Biodisel yang efektif, efisien dan ekonomis. Melihat kebutuhan biodisesl yang cukup besar, oleh sebab itu PT. AB berupaya untuk meningkatkan produksi solar dengan cara melakukan pencampuran (blending) beberapa komponen yaitu Solar, dan Fame. Dalam proses perhitungan parameter yang digunakan adalah Density, Flash Point , Cetane Index dan  untuk mendapatkan komposisi komponen blending yang optimum dan menghasilkan produk Biodisesl yang memenuhi spesifikasi serta memperoleh keuntungan yang tinggi. Dari proses optimasi yang dilakukan didapatkan kondisi blending yang paling optimum  di  dan menghasilkan produk Biosolar yang memenuhi spesifikasi serta dari komposisi blending tersebut didapatkan total biaya produksi komponen yakni 194.310.488 rupiah/bulan.
OPTIMASI FLOWRATE COOLING AIR TERHADAP PERUBAHAN TEMPERATURE COLD CLINKER PADA GRATE COOLER 472 GQ1 DI PT SOLUSI BANGUN INDONESIA
Authors: Amanda Diki
Published: February 2023

Grate cooler merupakan salah satu jenis clinker cooler yang berfungsi untuk mendinginkan Clinker secara cepat (quenching) pada proses produksi semen. Proses pendinginan di Grate Cooler merupakan salah satu bagian penting dalam menentukan kualitas semen. Pembuatan semen membutuhkan pendinginan clinker panas pada temperature sekitar 1450  hingga temperature ± 100?. Temperature cold clinkerkeluaran Grate Cooler di PT Solusi Bangun Indonesia adalah 218?. Dengan data yang diperoleh, penulis mencoba untuk melakukan optimasi Flowrate Udara Pendingin pada Grate Cooler 472-GQ1 di PT Solusi Bangun Indonesia dengan harapan temperature cold clinker dapat diturunkan dari 218? ke ± 100?. Metode yang digunakan oleh penulis untuk mengevaluasi effisiensi Grate Cooler 472-GQ1 adalah dengan metode heat loss, kemudian dengan menggunakan metode trial and error dilakukan simulasi penambahan flowrate udara pendingin sehingga temperature cold clinker  yang dihasilkan sesuai dengan yang diinginkan. Pada titik optimum flowrate udara pendingin, yaitu 2,35 Nm3/kg clinker mampu menurunkan temperature cold clinker sebesar 102?, serta meningkatkan efisiensi Grate Cooler dari 64,31% sampai 77,69%. dengan penghematan penggunaan batubara pada kiln sebesar Rp. 36.728.688,8 7/hari dan pada calciner sebesar Rp. 147.095.615,24/hari.
El préstamo simple o mutuo y su posible resolución por incumplimiento
Authors: Santana Navarro Francisco
Published: February 2023

Este trabajo analiza la posibilidad de resolver el contrato de préstamo simple por incumplimiento, de acuerdo con el artículo 1124 del Código Civil, a pesar de que tradicionalmente se le ha atribuido un carácter real y unilateral. Admitida la resolución del préstamo, determinaré qué entidad será exigible al incumplimiento resolutorio en función del tipo de préstamo, así como sus efectos. Asimismo, el trabajo analiza la nulidad por abusividad de las cláusulas de vencimiento anticipado por impago, y sus consecuencias sobre la subsistencia del contrato. Realizaré una valoración crítica de la doctrina jurisprudencial según la cual los préstamos hipotecarios no pueden subsistir sin tales cláusulas, y su anulación perjudica al consumidor. De tal doctrina, el Tribunal Supremo deriva la necesidad de sustituir la cláusula viciada por una norma posterior, el artículo 24 LCCI, sin remitir, por tanto, a las partes a un proceso declarativo, lo que entiendo disuadiría al profesional de su utilización. No obstante, esta jurisprudencia se limita a los préstamos hipotecarios, por lo que el artículo 1124 CC será un precepto relevante en los casos de incumplimiento del contrato de préstamo de tipo personal pero, además, en determinadas circunstancias y aspectos, operará ante el incumplimiento del contrato de préstamo hipotecario.
Sentencias comentadas. Inclusión en el catálogo de aguas privadas. STS 1320/2022, de 29 de marzo
Authors: Menéndez Rexach Ángel
Published: February 2023

La sentencia, partiendo de la existencia del aprovechamiento de aguas subterráneas con anterioridad a la Ley de 1985, confirma la de instancia, calificando la acción ejercitada como mero declarativa y no constitutiva ni de condena. Tras un detallado examen del régimen transi- torio de la citada Ley, desestima los motivos de casación y declara la obligación de la Confederación Hidrográfica de inscribir la titularidad del aprovechamiento en el Catálogo de aguas privadas. El comentario concluye con unas reflexiones sobre la pertinencia de calificar estas aguas como privadas.
Analisis Yuridis Tindak Pidana Pembunuhan Kepala Desa Rato Kecamatan Parado Kabupaten Bima
Authors: Baharudin Baharudin
Published: February 2023

Sanksi pidana dalam KitabUndang-Undang Hukum Pidana (KUHP) sebenarnya sudah bisa memberikan efek jera terhadap pelaku Tindak Pidana Pembunuhan, namun disisi lain ancaman dan vonis dari Pengadilan bellum tentu dapat diterima oleh pihak keluarga korban Pembunuhan karena ancaman dan hukuman belum sebanding dengan hilangnya nyawa seseorang dari pembunuhan tersebut. Penulisan ini dilatar belakang terjadinya pembunuhan seorang Kepala Desa Parado Rato yang terjadi di Desa Parado Rato Kecamatan Parado kabupaten Bima pada tahun 2016 yang lalu. Dimana seseorang diduga telah melakukan pembacokan terhadap seorang Kepala Desa yang ada di kecamatan Parado Kabupaten Bima, dari kejadian tersebut kedua desa saling melakukan penyerangan dan pemblokiran jalan sehingga paktivitas masyarakat Kecamatan Parado lumpuh total beberapa hari.  Berdasarkan hal tersebut, penulisan hukum ini mengangkat rumusan masalah yakni apa yang menjadi faktor penyebab terjadinya tindak pidana pembunuhan kepala desa parado rato, Bagaimana penerapan hukum terhadap tindak pidana pembunuhan Kepala Desa Parado Rato. Metode pendekatan yang digunakan adalah yuridis krimonogilis dengan pengumpulan data secara empiris normatif. Data yang digunakan adalah data Hukum Primer, data hukum Sekunder dan data hukum tersier yaitu bahan yang memberikan petunjuk maupun penjelasan terhadap bahan hukum primer dan bahan hukum sekunder seperti yang dijelaskan dalam eknsiklopedia, kamus hukum, kamus bahasa Indonesia dan sebagainya, permasalahn penelitian ini dianalisis dengan menggunakan teori keadilan, kepastian dan kemanfatan Hukum. Dalam Tindak Pidana Pembunuhan tersebut terjadi gejolak yang panjang karena ada beberapa kejadian paska terjadinya Pembunuhan Kepala Desa Rato tersebut yang mengakibatkan kedua desa bertetangga saling melakukan penyerangan. Disamping terjadinya konflik dan premanisme atas tindak pidana tersebut, telah terbongkar satu motif yang begitu menghebohkan bagi warga kecamatan Parado atas pembunuhan tersebut yaitu motif balas dendam. Dari peristiwa tersebut  banyak pihak mengharapkan pelaku dihukum seberat-beratnya dan sebagian pihak mengarapkan hukuman pihak penegak hukum memberikan hukuman yang seadil-adilnya sehingga tercipta rasa keadilan.
A produção de texto no Livro Didático da Educação de Jovens e Adultos
Authors: Santana Andreia
Published: February 2023

Este artigo tem como principal objetivo analisar duas propostas de produção textual presentes no livro “Caminhar e Transformar”, destinado às séries finais do ensino fundamental, na modalidade da Educação de Jovens e Adultos (EJA). Para tal análise foi elaborada uma ficha baseada na concepção de ensino presente nos documentos oficiais e na contribuição de autores que trabalham com o livro didático, com o ensino e com a linguagem, entre eles Kleiman, Marcuschi e Bakhtin. Este artigo é um recorte de uma pesquisa de cunho qualitativo, predominantemente descritiva, com uma abordagem interpretativista. A partir da análise realizada, foi possível constatar que as propostas estão organizadas por gêneros e que estes são trabalhados durante toda a unidade temática. Percebeu-se também que a tecnologia e os gêneros digitais, tal como os gêneros orais, foram mal aproveitados.
Acute Kidney Injury in Patients with Diabetic Ketoacidosis at National Institute of Child Health
Authors: Ahmed Syeda Sadia , Khan Mashal
Published: February 2023

Objectives: To determine the frequency of acute kidney injury (AKI) in patients with diabetic Ketoacidosis at National Institute of Child Health (NICH). Materials and Methods: Totally 80 patients who were enrolled. Demographics data were noted. Five ml venous blood sample and urine sample were collected from of each child in aseptic conditions in sterilized container and sent to laboratory of the hospital for random blood sugar (RBS), serum urea, serum creatinine, serum electrolytes (Na, K, Ph,) complete blood count (CBC, hemoglobin (Hb), white blood cells (WBC), platelets count, arterial blood gas (ABG), and ketones. All were drawn at the time of admission and after 24 hours. All children were catheterized at time of admission to monitor urine output which is part of DKA protocol and was recorded at 6, 12, 24 hours. AKI were labelled according to KDIGO classification as stage I, II, III depending upon rise in serum creatinine from baseline or according to urine output at 6, 12, 24 hours. All the demographic details and duration of diabetes mellitus and DKA and its treatment were recorded on a predesigned data collection proforma. Results: Out of 80 patients, 44.3% were male and 55.7% were female with mean age of 9.63± 3.34 years. 67% of the patients were aged 7.1-14 years, followed by 27% patients were aged 1-7 years and only 5.7% patients were aged of 14.1-18 years. The mean Duration of hospital stay was 6.88±1.45 days. The Mean Hb and WBCs, and Platelets level were 12.13±1.9 g/l, 16.37±7.97 and 348836.3±140355.4 respectively. The mean PH of all the enrolled patients was found 7.08±0.14 and mean Bicarbonate was 7.54±3.37mmol/L. The mean RBS at admission time and after 24-hour treatment were 403.7±95.42 mg/dl and 266.7±65.1 mg/dl respectively. The mean Serum Urea at admission time and after 24-hour treatment were 36.6±28.9 mg/dl and 36.9±23.5 mg/dl respectively. And the mean serum creatinine (mg/dl) at admission time and after 24-hour treatment were 0.75±0.58 and 0.76±0.55 mg/dl respectively. The mean electrolytes (Na, K, Ph) at admission time and after 24 hours were 138.4±7.0 mmol/l and 139.1±4.0 mmol/l, 4.0±0.83 mg/dl and 4.88±4.83 mg/dl, 19.2±30.7 mg/dl and 16.1±22.0 mg/dl respectively. Frequency of AKI was 31.8% and patients needed for peritoneal dialysis were 3.4%. Practical implication: In our study it was find out that AKI is a common complication in patients with Diabetic ketoacidosis. So this study will help the clinical practioner to also treat the patients for acute kidney injury that will provide early recovery from all the symptom of acute kidney injury. Conclusion: AKI is a common complication in children who are admitted for DKA and clinical practitioner should take precautionary parameter to avoid such complication. Keywords: Acute Kidney Injury, Diabetic Ketoacidosis, Children, DM, DM Type-1, child health, Frequency, NICH
Role of ERCP in Obstructive Jaundice
Authors: Iqbal Javed , Shah Makil , Ullah Mansour , Islam Zia Ul , Jafar Muhammad
Published: February 2023

Objectives: To determine the diagnostic role of ERCP in the management of obstructive jaundice. Materials and Methods: This cross-sectional study was done in Lady Reading Hospital Peshawar. In this study 60 patients with obstructive Jaundice were enrolled from April 2022–September 2022. All the enrolled patients were undergoing ERCP. Results: Total 80 patients were enrolled with mean age of 47.08±12.1 years. Out of total patients 68.3% were male and 31.7% were female. Stenting was done in 43.3% of patients and success rate was 88.5% and failure rate was 11.5%. Stone extractions were done in 20% of patients and success rate was 75.0%. Warm extractions were done in 10% and success rate was 100.0%. Sphincterotomy was done in 13.3% of patients and success rate was 100%. Some post complications were found, and the most common complication was acute pancreatitis that was 6.7%, followed by perforation that was 5%. Other post procedure complication were bleeding and acute cholangitis. Practical implication: In our study we find out that ERCP is an important diagnostic and therapeutic modality for evaluation of patients with obstructive jaundice. In our study the success rate is acceptable for ERCP in the management of obstructive jaundice. So this study will help the health practioner to choose better treatment option inorder to treat Obstructive Jaundice. Despite of its associated complication, ERCP is a reliable method in treating obstructive jaundice. Conclusion: It is concluded that ERCP is a best procedure having an affective role in the management of obstructive jaundice despite of complication. The success rate is in acceptable domain for ERCP in the management of obstructive jaundice. Keywords: Endoscopic retrograde cholangiopancreatography, Obstructive jaundice, Acute pancreatitis, Complication
A Study Based on the Helpful tool in the Initial Assessment of Ovarian Masses: Risk of Malignancy Index
Authors: Afroz Nighat , Basharat Nida , Khan Sanaullah , Khan Ansa , Jan Misbah , Muhammad Ghulam , Shabbir Hasnat
Published: February 2023

Objective: To evaluate the Risk of Malignancy Index (RMI)for primary evaluation of ovarian masses. Materials and Methods: This was a prospective observational study conducted for period of two years at DHQ hospital Jhang. Study consisted of 141 female patients admitted for surgical exploration of ovarian masses. Pre-operative ultrasound evaluation of ovarian mass, menopausal status and CA125 were carried out for the patients. Based upon these finding RMI was calculated for all the patients. Post-operative histopathology of resected ovarian mass was done in all the cases to confirm the diagnosis. Results: sensitivity and specificity of CA125 alone at cut off value of 35 was 67.64 %, 83.17% respectively. Using RMI at cut off value of 200 sensitivity and specificity was 76.47%, 85.98 % respectively. Receiver operating characteristic curve (ROC)revealed that RMI was a better discriminate than CA125, ultrasound and menopausal status alone. Practical implication: We can easily apply this tool for detection of ovarian masses. Conclusion: Risk of malignancy index (RMI) is useful tool in primary evaluation of ovarian masses. It can be used to differentiate between benign and malignant ovarian masses with high sensitivity and specificity. Keywords: Risk, Cancer, Malignancy, Benign
Outcome of total Laparoscopic Hysterectomy in adult females with Benign Uterine Pathology
Authors: Malik Kashaf Nadeem , Afridi Huma , Riaz Beenish , Shadab Wajiha , Afridi Itaat Ullah Khan
Published: February 2023

Background: Laparoscopic hysterectomy literature showed varied results regarding outcome of laparoscopic hysterectomy. Moreover, there is no local evidence which could help us to determine the outcome of laparoscopic hysterectomy in females having uterine pathology. Methods: This descriptive case series was conducted in the Department of Obstetrics & Gynecology, Imran Idrees Teaching Hospital Sialkot for a period of 11 months from 1-1-2022 to 30-11-2022. Total 175 patients fulfilling selection criteria were enrolled in the study from emergency. Then all females underwent laparoscopic hysterectomy under general anesthesia. During surgery, operative time was noted. During surgery, bladder injury was noted if occurred (as per operational definition). Patients were shifted in post-surgical wards and were discharged from there after recovery. Results: In this study the main outcome variables were operative time, hospital stay and bladder damage. Mean operative time and hospital stay for patients who underwent laparoscopic hysterectomy was 170.93±49.18 minutes and 2.63±0.60 days. None of the patients had bladder damage. Practical implication: Laparoscopic hysterectomy is a safe, effective, and reproducible technique that can be adopted after completing a period of training required to standardize the technique. It has been associated with lesser blood loss, shorter stay in hospital, quick return to normal activity, and fewer surgical site infections when compared with abdominal hysterectomy. This approach must be established in our real, day-to-day clinical practice. Conclusion: Laparoscopic hysterectomy is an effective procedure for benign uterine pathology in terms of minimal complication rate (bladder injury), shorter hospital stay and an average mean operative time. Hence showing very promising results and a better outcome for the patients Keywords: Laparoscopic Hysterectomy, Benign Uterine Pathology, Operative time, Hospital Stay
Epidemiology of Dupuytren’s and Sociodemographic Factors Related to it Among Chronic Diabetic Patients
Authors: Kalsoom Aleena , Iftikhar Sadia , Islam Farooq , Iqbal Tehreem , Sarwar Namra , Malik Arooj , Raza Asim
Published: February 2023

Background: Dupuytren’s disease(DD) is characterized by progressive idiopathic fibrosis of the hand palm and the formation of nodules & contractures. Its prevalence ranges from 3 to 42% worldwide. Aim: To assess Dupuytren’s disease’s prevalence, severity and its association with different demographic factors. Study design: Analytical, Cross-sectional study done using Non-probability convenient sampling. Method: This study was conducted on 424 diabetic patients of age between 40 and 80. A questionnaire was used to assess different sociodemographic factors among them. Tubiana classification & tabletop test was used to assess the severity of the disease. Chi-square test was applied to find out the p-value for the association between variables. Results: About 9% of total participants were affected by DD. Most of the affected people were in the nodular stage or stage 1.There was a significant relationship found between DD and different factors like age group (p=<0.01),Family history of DD(p=<0.01), and previous hand injury (p=<0.01) Practical implication: This study provides us the baseline risk factors leading to the disease for better future interventions. Treatments gets easier when we reach the cause. Because nowadays the widely available treatment is surgical excision which is not a good option for everyone. Also there is a dearth of research on this emerging hand disability caused by diabetes that’s why this research is being conducted Conclusions: The results showed high prevalence of DD in diabetic patients with old age, positive family history of DD disease and previous hand injury. Therapeutic studies are required for the betterment of society and to prevent the disease from causing disability. Keywords: Contractures, Dupuytren’s disease, Dupuytren’s nodules, diabetes, personal factors, Family history.
Anti-cancer activity of Mebendazole, Metformin and Apricoxib in HT-29, MDA-MB-231 HelaandMCF-7cell lines: Preclinical trial
Authors: Rizvi Fatima , Asad Farah , Shaukat Lubna , Siddiqui Muhammad Atif , Qadir Farida , Qadir Abdul
Published: February 2023

Aim: To look at anti-cancer effects of a variety of novel drugs on a variety of cancerous cell lines in the quest for a more inexpensive and effective anti-cancer treatment. Methodology: The research was carried out in conjunction with PCMD at JPMC's BMSI Department of Pharmacology. The experiment lasted about eight months (from April to November 2016). Noninvasive estrogen-dependent tumours, invasive estrogen-independent breast cancer, colorectal cancer, and cervical cancer were all depicted using MCF-7, HT-29, MDA-MB-231and HeLa cell lines, in that order. The MTT assay was used to improve the drugs' anticancer or antiproliferative efficacy in vitro. Using the MTT test, we determined the vitality of all treated tumour cell lines as well as the IC50 values of each chemical against all malignant cell lines. Results: This study demonstrated thatMetformin significantly decreased the survivability of MCF7, HT-29, MDA-MB-231, and Hela cell lines when compared to Apricoxib and Mebendazole. As a result, comparing the IC50 values of the studied agents for each of the evaluated treated cells backed up this claim. Hence, for Hela(p=0.386), MCF-7 (p=0.083), and MDA-MB-231 (p=0.083) cell lines but pochoc analysis revealed no significant differences in IC50 values of Metformin and Methotrexate. Conclusion: When compared to Apricoxib and Mebendazole, Metformin has a significant effect on the survivability of the cell lines studied. Metformin, as a result, would have been a wonderful chemotherapeutic addition Keywords: Cell lines, In vitro, MCF-7, Hela, MDA-MB-231
Different Doses of Lumbar Epidermal Methylprednisolone Injection and their effect on Pain Control and Blood Glucose Level in Diabetic patients
Authors: Mahmood Fahad , Akhtar Mohammad Mustajab , Khan Asad
Published: February 2023

Background: Frequency of diabetes mellitus is high between people suffering from lumbar spinal degenerative sickness Despite the fact that injection of steroid in epidural space are recognised to rise the glycaemic Blood amount postoperatively, therefore it is inquiry that decrease dose of methylprednisolone (40mg) cannot rise blood glycaemic level as compare to higher dose of methylprednisolone (80mg) and their effect on pain management of patients. Aim: To evaluate 2 common doses (80mg & 40mg) of methylprednisolone effects which is given through Epidural lumbar route, on glycaemic Blood level and pain management of diabetes mellitus patients to determine an adequate epidural steroid dose. Methods: This was an observational prospective study was conduct at Department of Anaesthesia Hayatabad Medical Complex Peshawar in June 2022. Overall 110 Diabetes mellitus patients were participated. They acquired lumbar epidural, methylprednisolone for spinal stenosis radiculopathy or failed back surgery syndrome. Methylprednisolone dose were given to patients, either 80mg (Group A) or 40 mg (Group B) was determined clinically after the procedure type. Results: HbA1c level was noted in group A 6.21mmol/L while in group B 6.52 mmol/L (p =0.991). The increase in fasting blood glucose (FBG) were greater significantly A Group than in B Group on post procedure day (PPD)1,2&3 (PPD1: 179 mg/dL A Group Vs 146mg/dL in B Group ), (PPD2: 221 mg/dL in A Group Vs 152mg/dL in B Group ) & (PPD3: 202mg/dL in A Group Vs 175mg/dL in B Group ). Fasting blood glucose incidence was >180mg/dL were greater in A Group than in B Group on post procedure day 1&2 (PPD1: A Group=11 vs B Group=5) and (PPD2: A Group=13 Vs B Group= 4). Conclusion: Methylprednisolone increase dose 80mg rise FBG and PDG greater than a decrease dose 40mg with no effect on pain management, employment status, or clinical outcome. Thus, it is recommended that methylprednisolone 40mg will b given rather than 80mg in diabetes mellitus patients with respect to pain management and blood glycaemic level Keywords: Epidural methylprednisolone, back pain, blood glucose.
Formation of Professional Identity in Pediatric Residents Working in Military Hospitals
Authors: Khushdil Arshad , Waqar Shahzad Hussain
Published: February 2023

Background: Professionalism is one of the basic attributes of a doctor patient relationship. During development of professional identity, doctors interact with their community which provides opportunity for mutual negotiation of identity and they keep improving their abilities. The development of this professional identity is a difficult skill indoctors working in Military hospitals. Aim: To explore development of Professional Identity in doctors working in pediatrics department of military hospital. Study design: Qualitative study based on phenomenological design. Place and duration: The study was conducted in Combined Military Hospital Quetta from Jan 2022 to June 2022. Methodology: All doctors serving in uniform in paediatrics department were included.In depth interviews were taken, recorded, transcribed and anonymized. Data interpreted manually, common themes originating from interviews were analysed and results formulated. Results: Six themes were found from transcript. Participants discussed about their professional life during service in military and road to gain professional excellence. Conclusion: Military residents working in paediatrics department have dual roles of serving the nation during peace as well as war and natural disasters. Keywords: Professionalism, Professional Identity, Paediatrics, Military.
Antioxidant effects of Citric Acid on Myocardium
Authors: Siddique Wardah , Aziz Hafiz Muhammad Imran , Mushtaq Sidra , Zubair Amina , Anwar Obaid
Published: February 2023

Background: Myocardial ischemia is associated with myocardial damage and necrosis. The pathogenesis of myocardial damage includes increased oxidative stress and diminished antioxidant defense. Aim: To assess levels of oxidative stress and scavenger enzyme system in experimental model of ischemia. Study design: This was a randomized experimental study. Place and duration: King Edward Medical University and University of Veterinary & Animal Sciences, Lahore for six months. Methodology: Thirty male rabbits were randomly divided into three groups. Control--group: animals got normal saline 1ml per oral for 14 days. ISO--group: animals got normal saline 1ml per oral for 14 days. CA+ISO--group: animals got citric acid 500 mg/kg body weight per oral for 14 days. Myocardial infarction was induced on 15th day in CA-group and CA+ISO-group by two doses of isoproterenol, administered subcutaneously at the interval of 24 hours. (isoproterenol dose= 85mg/kg body weight). To measure cTn-I (serum cardiac troponin I), tissue SOD (Super -oxide dismutase), CAT(catalase), GPx (glutathione peroxidase), GR (glutathione reductase), MDA (Malondialdehyde) and GSH (total reduced glutathione) animal serum was obtained from blood sample. SPSS was utilized to analyze the data. Quantitative data was shown as mean ± standard-deviation. One way analysis of variance and multiple comparison test LSD was applied. p value ≤0.05 was considered as statistically significant. Result: ISO--group showed significant decline in the level of SOD, CAT, GPx, GR and GSH as compare to control—group. ISO-group showed significant rise in the level of cTn-I and MDA. CA-group showed significantly recovery in SOD, CAT, GPx, GR and GSH levels in comparison to ISO-group. CA-group also showed significant decline in levels of cTn-I and MDA. Practical implication :Consumption of citric acid or diet rich in citric acid enhances the scavenger enzymes capability thus protects from acute myocardial infarction. Conclusion: It is concluded that citric acid possess strong anti-oxidant potential. It improves the anti-oxidant capability of myocardium in term of GSH content and level of scavenger enzymes in ischemic myocardium that help myocardium to battle against free radical injury and survive during ischemic condition. Keywords: Antioxidant, citric acid, SOD, CAT, GPx, GR, GSH
La recepción de un mito clásico en clave cristiana: el ave fénix en Clemente de Roma
Authors: Calabrese Claudio , Junco Ethel
Published: February 2023

En la Primera carta a los Corintios, Clemente de Roma establece una correlación entre la cultura helenístico-romana y la revelación, a través de la cosmología estoica y el mito del Fénix. Tal cosmología sostiene que cada elemento de lo real es solidario con los restantes, lo que establece el fundamento para una lectura simbólica del mundo. El Fénix es presentado como un signo prodigioso de la resurrección; por ello, nuestro autor no se pregunta si la historia es cierta o no, sino que ofrece al lector aquellos elementos que pueden colaborar con la comprensión del dogma central de la resurrección.
Analysis on the Creative Communication Strategy of Xiaohongshu Beauty Cosmetics from The Media
Authors: Han Yinuo
Published: February 2023

With the rapid development of China's overall economy and the continuous improvement of people's living standards, the subjective purport of society, the aesthetic standards of the public and the pursuit of beauty are also constantly changing. In the Internet era, media bloggers emerge in an endless stream. Many women use social platforms to create and disseminate content in the form of pictures, short videos and live broadcasts. Xiaohongshu, as a popular interactive platform for life sharing in China, is highly sought after by young people, especially college students. Taking Xiaohongshu's online marketing as an example, this paper combs the communication ideas of beauty cosmetics from the media, which is helpful to understand the communication strategies and guiding ideas, and then carry out practice and exploration. It has certain reference significance for brand positioning, shaping, brand influence and the promotion of consumer identity, so as to promote the creative communication of beauty cosmetics from the media.
Research on Rreferential Tax Policy of Sports and Health Service Industry
Authors: Hu Congyao , Wang Sicong , Chen Chang
Published: February 2023

Against the backdrop of Healthy China, the development scale of China's sports industry continues to expand, the overall volume of the sports health service industry increases rapidly, and the structure of industrial development is further deepened. Taking the preferential tax policies of the sports health service industry as the research object, this paper analyzes the developmental status of preferential tax policies of the sports health service industry in China. The preferential policies for sports industry tax are not wide enough, the preferential policies for tax are not detailed enough, and it is difficult to operate and implement. Then, further reasonable suggestions for optimization are put forward, aiming to enrich the theoretical research related to the sports industry, provide some guidance for improving the industry's preferential tax policies, and ultimately help its sustainable development.
Study on the Spatial Distribution Pattern of Catering Industry in the Urban Center of Kunming from 2012 to 2022
Authors: Zhang Xue , Zhang Runni , Wan Yangtao
Published: February 2023

Taking the urban center of Kunming as the study area, this paper extracts the POI data of the catering industry in 2012, 2016, 2020 and 2022 of Kunming by adopting web crawler technology, and then the average nearest neighbor index, geographic concentration index, kernel density analysis and spatial autocorrelation index are used by this study to conduct a comparative study on the spatial distribution pattern of the catering industry in the urban center of Kunming so as to explore its spatial clustering and evolutionary characteristics. The study results show that: (1) The development trend of the spatial pattern of the catering industry in the urban center area of Kunming is consistent with the urban development planning of Kunming, with the center clustering and expanding outward. (2) Although relying on commercial centers, tourist hotspots and university campuses, catering points form a multi-center distribution and "large aggregation, small dispersion" spatial pattern, the spatial distribution is unbalanced. (3) The spatial distribution pattern of catering industry is consistent with the overall spatial distribution pattern of catering industry, showing a multicenter gathering trend.