bluuebunny/crossref_metadata_2025 huggingface dataset:
A LONGITUDINAL STUDY ON THE USE OF PEER INSTRUCTION WITH CLICKERS TO TEACH INFORMATION MANAGEMENT
Authors: Laughton Paul A.
Published: July 2020

The objective of this research was to determine whether students would benefit from the incorporation of a teaching method known as peer instruction with clickers in first year information management classes at the University of Johannesburg, South Africa. Quantitative data was collected from selected classes over a period of two years. An attempt was made to confirm whether the benefits from using peer instruction with clickers recorded in previous studies were applicable to the subject of information management. Half of the selected classes used peer instruction as a teaching method, while the remaining half used a conventional face-to-face, one-to-many teaching method. Clickers were used to collect data from all classes, enabling a comparison of the two teaching methods. The different teaching methods applied revealed varying responses from the students, which also revealed different results in their class test scores. This quantitative data may potentially prove some benefits of using peer instruction with clickers to teach information management.Keywords: clickers, information management, peer instruction
AN ASSESSMENT OF E-RECORDS READINESS AT THE MINISTRY OF LABOUR AND HOME AFFAIRS, GABORONE, BOTSWANA
Authors: Moatlhodi Trevor Monare , Kalusopa Trywell
Published: July 2020

This study sought to assess electronic records (e-records) readiness at the Ministry of Labour and Home Affairs (MLHA), Gaborone, Botswana, within the purview of the implementation of an e-records management solution â€“ the National Archives and Records Management System (NARMS). The assessment was done using tenets derived from the existing International Records Management Trust (IRMT) E-records Readiness Tool. The assessment examined the national legal and policy framework, compliance with policies, standards, tools, procedures and responsibilities for records management, e-records management products and technologies, resource capacity and training for records management staff, internal awareness of records management programme and the level of management ownership on e-records management. The study largely adopted a qualitative approach, but used methodological triangulation of both qualitative and quantitative data collection methods, with a case study research design. Data was collected through semi-structured questionnaires, semi-structured interviews, and observations. Respondents comprised of records management staff, action officers (records users) and Information Technology (IT) Manager. The study findings revealed that the level of e-records readiness at the MLHA included: inadequate legal and regulatory framework; average adherence to records management procedures, tools and standards; low awareness among staff of the records management programme and, the national regulatory framework and on the NARMS pilot project; limited space for records management; slow progress in the implementation of NARMS and low capacity building as records management staff is rarely taken for training. The study also revealed that opportunities for increasing the depth of e-records readiness exist, such as: availability of financial resources for the NARMS pilot project; adequate Information Communication Technologies (ICT) infrastructure and high management commitment on the E-Records Management (NARMS pilot project). The study recommends: improvement of the national legal and policy framework by development of an e-records policy; development of a records management policy to provide an internal records management framework; regular training for records management staff, especially on e-records; regular internal records management awareness; and assigning senior management high-level responsibility for organisation-wide records and information management.
Proposal for Improving Records Management Practices of Traditional Institutions in Ga Molepo, South Africa
Authors: Molepo Mahlaga Johannes , Cloete Linda M.
Published: July 2020

The way in which an institution treats its records is crucial for its survival in a rapidly changing society. The purpose of the study was to investigate the records management practices and challenges faced by traditional institutions of leadership and governance in Ga Molepo, Limpopo, South Africa. The researcher employed a cross-sectional survey in order to quantitatively examine the challenges faced by members of traditional councils. A researcher administered questionnaire was used as a data collection tool to study a stratified sample of 35 members from an estimated population of 350. The findings revealed patterns and trends of non-compliance with records management standards and guidelines. Although there were sporadic cases of record keeping, a greater number of respondents revealed that traditional institutions lack the facilities, equipment, education and trained/skilled personnel to apply correct records management procedures in their daily administration of their traditional communities. The main value of the study is to create awareness of records management as one of the neglected areas in traditional institutions – which are by current legislative arrangement, the closest form of leadership and governance for rural communities in light of their relationship with local municipalities and the Department of Cooperative Governance and Traditional Affairs.
The Role of Storytelling in Preserving Africa's Spirit by Conserving the Continent's Fauna and Flora
Authors: Schellnack-Kelly Isabel
Published: July 2020

The importance of oral tradition, indigenous stories and the knowledge and wisdom contained therein are fundamental to undertake as many initiatives as possible to protect the continent's fauna and flora from extinction. This article is a phenomenological qualitative study. It is based on an extensive content analysis of literature, oral histories, photographs and audiovisual footage concerning narratives and folklore relating to Africa's fauna and flora. For the purposes of this article, the content sample focuses specifically on narratives related to the African elephant, black rhinoceros and the lion. The article also relates to experiences of individuals in Kenya and South Africa involved in conservation efforts to protect Africa's wildlife. The geographical proximity of the collected narratives stretches from the Timbavati, in South Africa, through to Northern Kenya. This article illustrates how indigenous knowledge and oral histories have influenced Western mythology and thinking. The article also explores the significance attached by scholars to the continent's oral histories and indigenous knowledge and links knowledge to Jung, astrology and ancient symbolism. The discussion emphasises the importance of good conservation strategies for all areas of Africa to protect the fauna and flora as well as Africa's oral histories and indigenous knowledge.
Relato de caso: mieloma múltiplo diagnosticado em paciente jovem e com eletroforese de proteínas normal
Authors: Coelho Caio Santiago Ferreira , Neto João Aprigio da Silva , Zeme Paulo de Tarso Talarico , Mendes Patrícia Marques , Junior Wilson Cunha , Silva Rodrigo Tavares
Published: July 2020

O mieloma múltiplo (MM) é uma neoplasia maligna, progressiva e incurável. Acomete células do tipo B, tendo como característica a proliferação descontrolada de plasmócitos. A prevalência é maior a partir da quinta década de vida, em homens e negros com história. É uma doença que apesar do tratamento, afeta qualidade de vida e não tem bom prognóstico. A maioria dos pacientes é sintomática e a dor óssea é o sintoma mais frequente. O tratamento é feito com quimioterapia a depender do estadiamento. O paciente estudado era do sexo masculino, 32 anos, pardo com queixa de 15 dias de dores intensas em região lombar, sem alívio com medicação, associado a vômitos e perda de peso. As tomografias de crânio e lombar demonstraram lesões líticas. A eletroforese de proteínas mostrou-se normal e o mielograma evidenciou 42% de plasmócitos, confirmando o diagnóstico com lesão renal aguda tratada na internação e foi encaminhado para tratamento. O diagnóstico de mieloma múltiplo pode ser feito nesse paciente pela apresentação de plasmocitose, hipercalcemia, lesão renal aguda. Evoluiu com anemia, além de dores como manifestação inicial. Divergiu da literatura, a idade do paciente, porém, etnia e sexo concordam com a literatura.
A atuação do(a) psicólogo(a) hospitalar na assistência ao paciente crítico
Authors: Modesto Lucas de Almeida , Teles Tony Anderson Xavier , Lima Hellen Cristiane de Freitas , Tonin Icaro Mercides Almeida , Lins Ana Carolina Araujo de Almeida
Published: July 2020

Objetivo: Verificar qual a atuação do profissional de psicologia na assistência ao paciente crítico através de uma revisão integrativa da literatura, buscando evidenciar o perfil dos trabalhos publicados nas fontes de indexação de maior impacto em âmbito nacional, de modo a possibilitar um melhor direcionamento dos estudos relativos a este conceito. Métodos: Foram utilizadas as bases de dados eletrônicas Scientific Electronic Library Online (SciELO) e Periódicos Eletrônicos de Psicologia (PePSIC). Os critérios de inclusão são: artigos indexados e disponíveis na íntegra no período de janeiro de 2009 a setembro de 2019; que estejam no idioma português; com temáticas que sejam pertinentes ao objetivo dessa revisão. Resultados: A atuação do psicólogo hospitalar com o paciente crítico necessita de técnicas e formas de intervenções que deem conta das especificidades no tratamento deste referente a procedimentos de outros profissionais, além do local em que este paciente pode se encontrar. A atuação neste contexto pode envolver o paciente, a família e a equipe multidisciplinar. Considerações finais: Os estudos investigados apontam que a atuação do psicólogo leva em consideração tanto a vontade do paciente quanto a melhor terapêutica proposta pela equipe, além das múltiplas formas que a família pode auxiliar no tratamento quando orientada corretamente.
Síndrome de Burnout em professores universitários: revisão integrativa da literatura
Authors: Oliveira Maricélia Tavares Borges , Martins Antonio Marques , Justino Monielle Guerra , Oliveira José Humberto Gomes , Pisano Simonetta , Pessoa Clelson Gomes da Silva , Gomes Rayane Cristina Rodrigues Pessoa , Silva Valdirene Cássia da , Borges Ana Kleiber Pessoa
Published: July 2020

Objetivo: Investigar a temática da Síndrome de Burnout em professores universitários, em dissertações e teses brasileiras. Métodos: Trata-se de uma revisão integrativa, realizada com suporte em resumos disponíveis na base de dados do Portal de Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (Capes) dissertações e teses, que utilizou como assunto para a busca Síndrome de Burnout, docentes, universidades, estresse ocupacional na qual foram encontradas 37 produções, no período de 2008 a 2018. Resultados: A pesquisa resultou em 37 estudos relacionados à Síndrome de Burnout em professores universitários, dos quais 21 são dissertações de mestrado acadêmico, 10 são teses de doutorado e 06 são dissertações de mestrado profissional. As tabelas mostram sequência das produções científicas da pós-graduação brasileira encontradas no Portal CAPES teses, referente ao tema abordado. Considerações finais: Constatou-se crescimento do número de produções sobre a temática, sendo a área da Administração a mais sensibilizada pelo tema. Em relação à implementação educativa na prevenção desta patologia, observaram-se poucos estudos com este objetivo. Concluiu-se, então, a necessidade de elaborar pesquisas que valorizem a Síndrome de Burnout como foco de intervenção que visem à melhoria da qualidade do trabalho de docentes e demais profissões.
Vivência dos pais nas etapas hospitalares do método canguru: revisão integrativa
Authors: Menezes Deusa Daniel de Oliveira , Santos Deisy Vital dos , Morais Aisiane Cedraz
Published: July 2020

Objetivo: Descrever a vivência dos pais com o Método Canguru (MC), na primeira e segunda etapa, a partir das publicações científicas brasileiras. Métodos: Revisão integrativa da literatura, realizada nas bases de dados da Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), da Scientific Electronic Library Online (SCIELO) e no Portal de periódicos CAPES/MEC, utilizando o descritor: “Método Canguru”, com recorte temporal do ano de 2003 a 2018. Resultados: O MC apresenta benefícios para a díade criança e família, quando promove sentimentos positivos, empoderamento, criação de vínculo e favorece o aleitamento materno. Todavia, também é possível identificar alguns dilemas e dificuldades, como o sentimento de medo e culpa, mudanças na dinâmica familiar e social e temores provenientes do ambiente hospitalar. Isto demanda um processo de construção e desconstrução na relação estabelecida entre a família, a criança e a equipe de saúde, de modo que haja sucesso na utilização do método. Considerações finais A vivência dos pais nas etapas hospitalares do método canguru é permeada por múltiplos sentimentos, vinculados ao método propriamente dito e associados a relação com a equipe de saúde. Identificou-se lacunas quanto a investigação dos aspectos sociais dos pais que vivenciam o MC no SUS.
Espectro clínico da infecção por COVID-19 nos organismos humanos: revisão bibliográfica
Authors: Vasconcelos Júnior Francisco Clezion Franca , Mouta Alba Angélica Nunes , Aragão Ravena Vasconcelos , Barbosa Giovanna Stefanne Lópes , Lopes Priscila Favoritto , Da Silva Augusto César Beltrão , Gândara Brisa Fidelis , Beltrão Bruna Caroline Ribeiro , Beltrão da Silva Demétrio Félix , Beltrão Renata Paula Lima
Published: July 2020

Objetivo: Analisar através de uma revisão as apresentações clínicas mais relevantes da infecção pelo SARS-CoV-2. Revisão Bibliográfica: O COVID-19 possui um espectro amplo de apresentações. A forma assintomática é um desafio diagnóstico, levando à subnotificação. Acredita-se que ocorram em indivíduos com eficiente defesa antiviral e resposta imune efetiva, mas incapazes de bloquear completamente o vírus. A Síndrome Gripal Leve representa 80% dos casos sintomáticos, manifestados através de febre, tosse, fadiga, dispneia e mialgia. Os casos graves, de 5-10% dos sintomáticos, geralmente se expressam por pneumonia, com alterações de sinais vitais, dispneia ou disfunção orgânica; além disso, podem evoluir para uma Síndrome do Desconforto Respiratório Agudo, com complicações respiratórias, alterações radiográficas e da PaO2/FiO2. A Sepse e Choque séptico por COVID-19 possuem ainda maior chance de desfecho desfavorável, condições que indicam permanência do paciente em ambiente de terapia intensiva. Considerações Finais: Pouco ainda se sabe sobre o COVID-19, mas seu alto potencial de transmissibilidade e sua variabilidade de apresentações clínicas são reconhecidos como fatores complicadores do controle da epidemia.
Sejarah Tradisi Sendang Dan Nilai Sosial-Religius Desa Tetep Kelurahan Randuacir Kecamatan Argomulyo Kota Salatiga
Authors: Fitriyani Aida , Widiarto Tri , Sunardi Sunardi
Published: July 2020

Sendang merupakan sumber air yang tidak pernah mengalami kekeringan. Kebanyakan sendang di tanah Jawa bersifat sakral serta di hormati. Di Desa Tetep sendang adalah tempat yang di sakralkan dan di hormati dengan melaksanakan tradisi atau upacara adat. Tradisi Sendang di Desa Tetep dilakukan pada dua sendang yang biasa disebut dengan sendang Ki Godong mPlati, Nyi Godong mPlati, dan Ki Gambreng. Tradisi ini dilaksanakan oleh masyarakat Desa Tetep saat mengadakan acara besar. Tradisi Sendang dilaksanakan bertujuan untuk menghormati dan meminta kelancaraan acara tersebut kepada Yang Maha Esa melalui perantara sendang. Tujuan penelitian ini untuk mengetahui makna dan nilai sosial-religius yang terdapat pada tradisi sendang pada masyarakat Desa Tetep. Metode penelitian yang digunakan adalah wawancara, observasi, dokumentasi, dan kajian pustaka. Hasil penelitian ini mengambarkan tatacara pelaksanaan tradisi sendang di Desa Tetep. Pelaksanaan tradisi menjadi pelestarian budaya lokal. Tradisi ini mengandung mitos turun-temurun yang dipercaya masyaratkat Desa Tetep. Mitos yang di implementasikan dalam budaya inilah yang membuat Tradisi Sendang mengandung nilai sosial-religius.
Islamofobia Di Australia: Imigrasi, Integrasi Dan Terorisme Dari Perspektif Sejarah
Authors: Labibatussolihah Labibatussolihah , Darmawan Wawan , Adriani Nour Muhammad , Fathiraini Nurdiani
Published: July 2020

Sebagai negara bercorak Barat di kawasan Asia-Pasifik, pemerintah Australia mempromosikan semangat multikulturalisme yang mendorong kesetaraan di antara komunitas masyarakatnya termasuk antarumat beragama. Di sisi lain kampanye â€œwar on terrorâ€ yang digagas Amerika Serikat pasca serangan 11 September juga berpengaruh pada persepsi masyarakat dunia yang melahirkan stigma â€œketakutan terhadap Islamâ€ atau Islamofobia termasuk di Australia. Melalui metode sejarah, telaah pustaka dilakukan untuk memunculkan alternatif sudut pandang Islamofobia di Australia secara historis. Dari perspektif ini ada beberapa hubungan yang dapat diambil, bahwa 1) kehadiran Islam di Australia meskipun sudah cukup lama tetapi belum berakar kuat secara historis; 2) persepsi orang Australia non-muslim terhadap Islam tidaklah buruk, namun terdapat sekelompok ekstrimis yang membenci Islam karena faktor citra negatif dan kebencian pribadi (personal dislike); 3) terdapat permasalahan integrasi masyarakat muslim di Australia salah satunya karena faktor perbedaan kultur asal muslim yang distigmatisasi secara umum; 4) penetrasi pemikiran radikal dikalangan umat Islam di Australia terjadi seperti halnya di masyarakat lain yang merasa tertindas atau termarginalkan.
Studi Historis Sekolah Kedokteran Di Indoensia Abad XIX
Authors: Dhita SBK Aulia Novemy
Published: July 2020

Pandemi Covid-19 saat ini menggemparkan dunia. Berbagai pihak dari seluruh negara, putar haluan fokus pada Covid-19, terlebih tenaga medis. Peristiwa semacam ini pernah dialami Indonesia pada masa Pemerintahan Kolonial Belanda yang kewalahan menghadapi penyakit Cacar. Berangkat dari peristiwa tersebut, sangat menarik untuk mengangkat permasalahan yaitu bagaimana sejarah sekolah kedokteran di Indonesia. Tujuan penelitian ini untuk merekonstruksi sejarah sekolah kedokteran di Indonesia. Adapun metode yang digunakan adalah metode historis yang meliputi tahapan heuristik, kritik sumber, interpretasi dan historiografi. Hasil penelitian menunjukkan bahwa sekolah kedokteran di Indonesia berawal dari epidemi Cacar yang melanda Jawa pada abad ke-19 dan perkembangnnya tidak lepas dari Politik Etis. Pemerintah Kolonial Belanda lalu membentuk Dokter Djawa School, yang kemudian bermetamorfosa menjadi STOVIA dan Geneeskundige Hoge School. Berbagai kebijakan dan revitalisasi kurikulum mewarnai perjalanan sekolah kedokteran di Indonesia. Saat ini sekolah kedokteran tersebut termasuk pendidikan vokasi dan fakultas kedokteran pada lembaga pendidikan tinggi di Indonesia.
Uslub ats-Tsuna-iyyah ash-Shugra fi Tadrisi Maharah al-Istima'
Authors: Hasibuan Jefry , Alfitri  , Yunita Yenni
Published: July 2020

إن مصطلح الثنائية الصغرى العلميّ يعني مجموعة من الكلمات الموضوعة على الشقين أو الناحيتين المتقابلتين، والكلمات حروفها متشابهة إلا حرف أو حرفين فيها، والاختلاف الواقع في بعض الحروف يسبّب حدوث الاختلاف في المعاني بينها. الثنائية الصغرى أسلوب من أساليب تدريب التمييز الصوتيّ. فمهارة الاستماع تقتضي تحقّق القدرة على تمييز الأصوات قبل فهم ما سمِع، ولما كانتْ الثنائية الصغرى تهدف إلى تنمية القدرة على التمييز الصوتي، ألحِقتْ الثنائية الصغرى بأنواع اختبار مهارة الاستماع. ومن هنا تتجلى أهمية هذه الدراسة حيث سيتحدث الباحث عن أهمية الثنائية الصغرى في تدريس مهارة الاستماع.
Tungsten-Catalyzed Direct N-Alkylation of Amines with Alcohols
Authors: Lan Xiao-Bing , Ye Zongren , Li Weikang , Liu Jiahao , Huang Ming , Liu Yan , Ke Zhuofeng
Published: July 2020

The implementation of earth-abundant metals mediated chemistry is a major goal in homogeneous catalysis. Borrowing hydrogen/hydrogen autotransfer (BH/HA) reaction, as a straightforward and sustainable synthetic method, has attracted considerable attention in the development of earth-abuandant metal catalysts. Herein, we report a tungsten-catalyzed N-alkylation reaction of amines with primary alcohols via BH/HA. This phosphine-free W(phen)(CO)4 (phen=1,10-phenthroline) system was demonstrated as a practical and easily accessible in-situ catalysis for a broad range of amines and alcohols (up to 49 examples, including 16 previously undisclosed products). Notably, this tungsten system can tolerate numerous functional groups, especially the challenging substrates with sterically hindered substituents, or heteroatoms. Mechanistic insights based on experimental and computational studies are also provided.
Pushing Nanomaterials past the Kilogram Scale—a Targeted Approach Integrating Scalable Microreactors, Machine Learning and High-Throughput Analysis
Authors: Jose Nicholas , Kovalev mikhail , Bradford Eric , Schweidtmann Artur , Zeng Hua Chun , Lapkin Alexei
Published: July 2020

Novel materials are the backbone of major technological advances. However, the development and wide-scale introduction of new materials, such as nanomaterials, is limited by three main factors—the expense of experiments, inefficiency of synthesis methods and complexity of scale-up. Reaching the kilogram scale is a hurdle that takes years of effort for many nanomaterials. We introduce an improved methodology for materials development, combining state-of-the-art techniques—multi-objective machine learning optimization, high yield microreactors and high throughput analysis. We demonstrate this approach by efficiently developing a kg per day reaction process for highly active antibacterial ZnO nanoparticles. The proposed method has the potential to significantly reduce experimental costs, increase process efficiency and enhance material performance, which culminate to form a new pathway for materials discovery.
Investigating Electrode Calendering and its Impact on Electrochemical Performance by Means of a New Discrete Element Method Model: Towards a Digital Twin of Li-Ion Battery Manufacturing
Authors: Ngandjong Alain , Lombardo Teo , Primo Emiliano , Chouchane Mehdi , Shodiev Abbos , Arcelus Oier , Franco Alejandro A.
Published: July 2020

Lithium-ion battery (LIB) manufacturing optimization is crucial to reduce its CO2 fingerprint and cost, while improving their electrochemical performance. In this article, we present an experimentally validated calendering Discrete Element Method model for LiNi0.33Mn0.33Co0.33O2–based cathodes by considering explicitly both active material (AM) and carbon-binder domain (CBD). This model was coupled to a pre-existing Coarse-Grained Molecular Dynamics model describing the slurry equilibration and its drying and a 4D-resolved Finite Element Method model for predicting electrochemical performance. Our calendering model introduces important novelties versus the state of the art, such as the utilization of un-calendered electrode mesostructures resulting from validated simulations of the slurry and drying combined with the explicit consideration of the spatial distribution and interactions between AM and CBD particles, and its validation with both experimental micro-indentation and porosity vs. calendering pressure curves. The effect of calendering on the electrode mesostructure is analyzed in terms of pore size distribution, tortuosity and particles arrangement. In addition, the evolution of the macroscopic electrochemical behavior of the electrodes upon the degree of calendering is discussed, offering added insights into the links between the calendering pressure, the electrode mesostructure and its overall performance.
Enantioselective Aryl-Iodide-Catalyzed Wagner–Meerwein Rearrangements
Authors: Sharma Hayden , Mennie Katrina , Kwan Eugene , Jacobsen Eric
Published: July 2020

We report a strategy for effecting catalytic, enantioselective carbocationic rearrangements through the intermediacy of alkyl iodanes as stereodefined carbocation equivalents. Asymmetric Wagner–Meerwein rearrangements of β-substituted styrenes are catalyzed by the C2-symmetric aryl iodide 1 to provide access to enantioenriched 1,3-difluorinated molecules possessing interesting and well-defined conformational properties. Hammett and kinetic isotope effect studies, in combination with computational investigations, reveal that two different mechanisms are operative in these rearrangement reactions, with the pathway depending on the identity of the migrating group. In reactions involving alkyl-group migration, intermolecular fluoride attack is product- and enantio-determining. In contrast, reactions in which aryl rearrangement occurs proceed through an enantiodetermining intramolecular 1,2-migration prior to fluorination. The fact that both pathways are promoted by the same chiral aryl iodide catalyst with high enantioselectivity provides a compelling illustration of generality across reaction mechanisms in asymmetric catalysis.
A Computational Study of the Relative Aromaticity of Pyrrole, Furan, Thiophene and Selenophene, and Their Diels-Alder Stereoselectivity
Authors: Yadav Veejendra
Published: July 2020

The collinearity of terminal p orbitals of a diene with that of a dienophile is required for an effective overlap to result in s bond formation during the Diels-Alder reaction. The ease of the DA reaction of a cyclic diene with a given dienophile, therefore, must also depend on the distance between the termini of the diene. A distance larger than the unsaturated bond of the dienophile is expected to raise the energy of activation. This scenario has been amply demonstrated from the study of reactions of several dienes, some designed to serve the purpose, with different dienophiles. The five-ring heterocycles pyrrole, furan, thiophene and selenophene possess varying aromatic character for the varied resonance participation of the heteroatom lone pair with ring p bonds. The aromaticity decreases in the same order due to: (a) the increasing sC-X (X = heteroatom) bond length lifts the bond uniformity required for ring current, hence aromaticity, such as in benzene and (b) size-mismatch of the interacting lone pair orbital and the ring p orbitals, especially in thiophene and selenophene, both allowing poor overlap in the ground state structures. It is demonstrated that increase alone in the activation energies of the DA reactions of pyrrole, furan, thiophene and selenophene cannot be considered a measure of relative aromaticity as often done and even theoretically attempted in many ways to prove just that. The separation of the termini of the diene has a much larger role in the determination of activation energy, especially in thiophene and selenophene, than their aromaticity profile. There cannot be a measure better than the relative intensity of heteroatom lone pair overlap with ring p bonds, giving rise to a six-electron like system in following Hückel’s 4n+2 rule, to assess the relative aromaticity.
Non-toxic Cobalt(III) Schiff Base Complexes with Broad Spectrum Antifungal Activity
Authors: Frei Angelo , King A. Paden , Lowe Gabrielle J. , Cain Amy K. , Short Francesca L. , Dinh Hue , Elliott Alysha , Zuegg Johannes , Wilson Justin J. , Blaskovich Mark
Published: July 2020

Resistance to currently available antifungal drugs has quietly been on the rise but overshadowed by the alarming spread of antibacterial resistance. There is a striking lack of attention to the threat of drug resistant fungal infections, with only a handful of new drugs currently in development. Given that metal complexes have proven to be useful new chemotypes in the fight against diseases such as cancer, malaria, and bacterial infections, it stands to reason to explore their possible utility in treating fungal infections. Herein we report a series of cobalt(III) Schiff base complexes with broad spectrum antifungal activity. Some of these complexes (1-3) show minimum inhibitory concentrations (MIC) in the low micro- to nanomolar range against a series of Candida and Cryptococcus yeasts. Additionally, we demonstrate that these compounds show no cytotoxicity against both bacterial and human cells. Finally, we report first in vivo toxicity data on these compounds in Galleria mellonella, showing that doses as high as 266 mg/kg are tolerated without adverse effects, paving the way for further in vivo studies of these complexes.
Lysosome Targeting Chimeras (LYTACs) That Engage a Liver-Specific Asialoglycoprotein Receptor for Targeted Protein Degradation
Authors: Ahn Green , Banik Steven , Miller Caitlyn L. , Riley Nicholas , Cochran Jennifer R. , Bertozzi Carolyn
Published: July 2020

Selective protein degradation platforms have afforded new development opportunities for therapeutics and tools for biological inquiry. The first lysosome targeting chimeras (LYTACs) targeted extracellular and membrane proteins for degradation by bridging a target protein to an endogenous lysosome targeting receptor, the cation-independent mannose-6-phosphate receptor (CI-M6PR). Here we developed LYTACs that engage the asialoglycoprotein receptor (ASGPR), a liver-specific lysosomal targeting receptor, to degrade membrane proteins in a tissue-specific manner. We conjugated antibody-based binders targeting cell-surface proteins to a tri-GalNAc motif that engages ASGPR. The resulting LYTACs directed lysosome trafficking of the bound targets and subsequent degradation. Degradation mediated by an EGFR-targeted GalNAc-LYTAC resulted in significant functional effects on the downstream kinase signaling of EGFR compared to canonical inhibition with a monoclonal antibody. Furthermore, we demonstrated that a small target binder, a 3.4 kDa peptide, can be linked to a single tri-GalNAc ligand to degrade integrins and significantly reduce cell proliferation. Site-specific chemical conjugation of one or two tri-GalNAc ligands to antibody scaffolds improved the pharmacokinetic profile of GalNAc-LYTACs in vivo compared to non-specific chemical conjugation. GalNAc-LYTACs represent an exciting new paradigm for cell-type restricted degradation of proteins.
Study of micronuclei in cervical pap smear
Authors: Sujata Kumbhar  , SujataKanetkar  , Avinash Mane  , AkankshaGore  , Parneetkaur  , Ankita Dad
Published: July 2020

Carcinoma of the cervix is a common cause of mortality in women regardless of effective screening methods. Screening for (MN) in cells has been one among the tests used in cancer screening. Several containing cells rises in carcinogen- exposed tissues much earlier than the symptoms. Here in this study usefulness of (MN) in screening cervical lesions was evaluated. We studied comparison of MN score among different cervical lesions and the significance of the difference in the score. We evaluated 406 cervical smears, categorized them using the “Bethesda 2014 system". Mean MN scores among the different cervical lesion categories were compared, and the differences were studied statistically for its significance. Results showed a gradual increase in mean MN score with increasing severity of the cervical lesion and the differences in these scores were statistically significant (P < 0.05) among all the categories, with significantly higher mean MN scores in high grade squamous wounds and invasive carcinomas (IC)than others. We concluded that the MN test could serve as an additional and practical screening test in conjunction with the conventional cervical Pap smear for cervical cancer screening.
Morphometry of human tricuspid valve: A cadaveric study
Authors: Kirti Chaudhary  , Amey Dhatrak  , Brij Raj Singh  , Ujwal Gajbe
Published: July 2020

The cardiovascular system consists of a pump represented by the heart and blood vessels, which provide the route by which blood circulates to all parts of the body. William Harvey, in the 17th century, discovered that blood is pumped away from the heart, but it all returns to the heart after circulating in the body. A right ventricular function can be compromised by pressure or stress, often secondary to the right heart valve or muscle pathology. The valves maintain unidirectional flow and permit increased pressure to develop in the chambers. The tricuspid valve consists of three tissue flaps. It separates the right atria and the right ventricle. To measure morphometric measurements of an individual leaflet of the tricuspid valve of cadaveric human hearts. The material for the present study comprised of 50 formalin-fixed adult human hearts (35 males and 15 females) which were obtained from the Department of Anatomy from various medical colleges in Maharashtra. Statistical significant difference was found for the height of anterior and posterior leaflets between male and female hearts. The length of the septal leaflet was also found to be statistically significant between male and female hearts. The study will be helpful for cardiac surgeons in providing data for tricuspid valve complex, leaflets, cords and papillary muscles.
Entrepreneurs and management system
Authors: Afreen Mehek
Published: July 2020

The entrepreneurs and management system has always influenced the organization to grow successfully. The entrepreneurship is a challenging tasks which needs the process of management tools. There has been upliftment of the management tools which are being implemented in different sectors.
La imagen Top of Mind de un Destino Turístico durante un Mega-evento. El Caso de Viana do Castelo y el Festival Vodafone Paredes de Coura
Authors: Almeida Ângela de , Cardoso Lucília , Vila Noelia Araújo
Published: July 2020

El presente artículo tiene como objetivo principal evaluar la imagen top of mind del destino (ciudad) Viana do Castelo durante el Festival Vodafone Paredes de Coura, así como la imagen del propio festival. A través de un cuestionario (n=395) de preguntas abiertas a los festivaleros se recogen las palabras evocadas sobre 11 criterios y se perfila la percepción de la imagen del destino por parte de este colectivo. Las respuestas de la evocación espontánea de los recuerdos adquiridos reflejan que el Festival Vodafone Paredes de Coura es el festival top of mind del país, seguido del festital NOS Alive y el Festival Super Bock Super Rock, caracterizándolo con atributos como “música”, “naturaleza” y “río”.
As Microescalas do Desenvolvimento Regional: Reflexões sobre o Direito à Cidade de Pessoas LGBTQI+
Authors: Souza Mariana Barbosa de , Ornat Marcio Jose
Published: July 2020

Objetivo - compreender a relação entre a concepção de desenvolvimento regional, segundo um caminho decolonial, e a vivência cotidiana de pessoas LGBTQI+ (Lésbicas, Gays, Bissexuais, Travestis, Transexuais e Transgêneros, Queer, Intersexuais e outras possibilidades de identidade de gênero e orientação afetiva-sexual), relacionando-as com o Direito à Cidade.Metodologia/abordagem (obrigatório): A metodologia empregada baseia-se especialmente em contraposições de análises de autores e autoras e a abordagem teórica adotada parte do conhecimento decolonial, envolvendo teorizações combinadas.Originalidade/Relevância (obrigatório): A sua originalidade e relevância são justificadas pela desvinculação da produção teórica do modelo hegemônico, em favor de um pensamento que permita vislumbrar outros modos de vida, relacionados às pessoas LGBTQI+, o que também se apresenta enquanto uma contribuição social.Principais resultados (obrigatório): Como resultado constatou-se que a efetivação do Direito à Cidade da população LGBTQI+ perpassa por questões que vão além da segurança e do combate à LGBTfobia, porque o Direito à Cidade é amplo. Emerge a necessidade de pensar políticas públicas, ações e mecanismos de transformação social e outras pesquisas que discutam o tema.Contribuições teóricas/metodológicas (obrigatório): Teoricamente e metodologicamente evidenciou-se que o desenvolvimento regional tem de ser compreendido para além de indicadores econômicos e que a categoria gênero mostra-se enquanto uma elaboração social e cultural, sobretudo quando pensada a partir da decolonialidade.
The role of universities in times of Crisis
Authors: Bridgman Todd
Published: July 2020

No description supplied
Institutions and technology: frameworks for understanding organizational change - the case of a major ICT outsourcing contract
Authors: Bridgman Todd , Willmott H
Published: July 2020

No description supplied
Whyte-Out: How the Creator of Groupthink Became Unseen by Management's History
Authors: Pol Oliver , Bridgman Todd , Cummings Stephen
Published: July 2020

Irving Janis’ (1971) concept of ‘groupthink’, the idea that the desire for consensus overrides the realistic appraisals of alternatives and leads to poor decision making, is a staple of management and organizational behavior textbooks. Despite gaining little support in empirical studies, Janis’ eight symptoms of groupthink remains a popular framework taught to budding managers. What has been forgotten, however, is that nearly 20 years before Janis’ supposed invention, groupthink was created by William H Whyte, author of one of the 1950s’ most influential and popular books on management. We investigate how Whyte’s link to groupthink became invisible to management’s history, why this matters, and how recovering Whyte’s ideas can provide fresh, critical insights into people dynamics in contemporary organizations."
Diverse complexities, complex diversities: Critical Qualitative Educational Research in Aotearoa (New Zealand)
Authors: Ritchie Jenny
Published: July 2020

This paper offers an overview of complexities of the contexts for education in Aotearoa, which include the need to recognise and include Māori (Indigenous) perspectives, but also to extend this inclusion to the context of increasing ethnic diversity. These complexities include the situation of worsening disparities between rich and poor which disproportionately position Māori and those from Pacific Island backgrounds in situations of poverty. It then offers a brief critique of government policies before providing some examples of models that resist 'normal science' categorisations. These include: the Māori values underpinning the effective teachers' profile of the Kotahitanga project and of the Māori assessment model for early childhood education; the dispositions identified in a Samoan model for assessing young children's learning; and the approach developed for assessing Māori children's literacy and numeracy within schools where Māori language is the medium of instruction. These models all position learning within culturally relevant frames that are grounded in non-Western onto-epistemologies which include spiritual, cultural, and collective aspirations.
Early childhood education professionals in New Zealand kindergartens. Commitment and challenges
Authors: Ritchie Jenny , Veisson Marika
Published: July 2020

No description supplied
Social, cultural, and ecological justice in the age of the Anthropocene: A New Zealand early childhood care and education perspective.
Authors: Ritchie Jenny
Published: July 2020

© 2016 by Jenny Ritchie. Educators have an ethical responsibility to uphold the wellbeing of the children, families and communities that they serve. This commitment becomes even more pressing as we move into the era of the Anthropocene, where human induced climate changes are disrupting the planet's systems, threatening the survival of not only humans, but of eco-systems and the earth's biodiversity. This paper draws upon examples from Aotearoa (New Zealand) to demonstrate ways in which a critical pedagogy of place informed by local traditional knowledges can inform early childhood education whilst also enhancing dispositions of empathy towards self and others, including more-than-human others.
Early childhood education as a site of ecocentric counter-colonial endeavour in aotearoa New Zealand
Authors: Ritchie Jenny
Published: July 2020

This article draws upon a range of theoretical domains, first to outline the historical rationale for the urgent changes needed to challenge and transform the dominator culture which has justified exploitation of Indigenous peoples and the resources of the earth. It invites educators to reconsider the narratives that are either consciously or inadvertently promoted in our work, suggesting that we can learn from Indigenous epistemologies in which humans are situated alongside earth others, as respectful, related guardians and caretakers. It finally draws on some examples from a recent qualitative study conducted with ten early childhood centres from across Aotearoa, to illuminate possibilities for enactment of counter-colonial renarrativisation within early childhood settings in service of an ethical project of enhancing relationalities, reconnecting children and their families with the more-than-human world.
EMPOWERING ISLAMIC BOARDING SCHOOL IN IMPROVING ITS HUMAN RESOURCES IN BATANG HARI REGENCY JAMBI PROVINCE (THE STUDY AT UMMUL MASAKIN ISLAMIC BOARDING SCHOOLS IN BATANG HARI REGENCY)
Authors: Maisah  , Yamin H. Martinis , Yamin H. Martinis , Madyan
Published: July 2020

The existence of Islamic boarding schools in Jambi province, present as a place which give image to Islamic boarding schools that familiarize students to recognize and to study religious knowledge in depth by applying it in the daily lives of the students. Therefore, it will become a habit in the students behavior. Ummul Masaqin Islamic Boarding School is one of the modern Islamic boarding schools which proclaims itself as an open-minded mass organization in the hope that it can be more flexible and more agile to play an active role in solving social problems.

By continuous development of the times, the students are expected to be able to follow these developments. Islamic Boarding Schools see the importance of developing the function of Islamic boarding schools as a center for scientific and religious development, and as a center for the empowerment of students. Therefore, Islamic Boarding Schools made a new breakthrough by carrying out empowerment strategy for their students. This empowerment strategy is an effort of Islamic Boarding Schools to increase the resources of the students.

This research is a field research that uses qualitative research method or approach. The focus of the research is centered on the issue of empowering Islamic boarding school in improving its human resources in Jambi Province, by using data collection techniques: observation, interviews and documentation. The type of data used is primary and secondary data. The data validity technique uses data triangulation.

The research findings are: 1) Ummul Masakin Islamic Boarding School teaching and educating staff recruitment is conducted by planning through estimation of employee requirements and estimation of internal supply of human resources. 2) The empowerment of Islamic boarding schools in improving human resources in the Islamic Boarding School in Batang Hari conductedin the form of (a) Recitation, (b) Al-Qur'an Educational Park, (c) Poskenstren, (d) Kopontren. 3) Islamic Boarding Schools prepares future scholars by empowerment in Ummul Masakin Islamic Boarding School through various activities / coaching, namely: (a) The Development of the Khitabah, (b)The Development of the Kitab Kuning Study.
RELATIONSHIP OF STUDENT TEACHING AND COMPREHENSIVE EXAMINATION IN THE LICENSURE EXAMINATION FOR TEACHERS (LET) PERFORMANCE OF TEACHER EDUCATION GRADUATES
Authors: Abrea Rowena R. , Gayeta Norrie E. , Comia Rosalinda M. , Reyes Joy M.
Published: July 2020

This study determined the relationship of student teaching and comprehensive examination in the Licensure Examination for Teachers from 2014 to 2018. Using PRC LET results and grades in student teaching and comprehensive examination, this study employed documentary analysis and correlation research designs.

Findings of the study revealed that the graduates received an outstanding performance in student teaching. Results also showed that more than one half of the graduates had fairly satisfactory rating in the comprehensive examination, and most of them did not meet expectations in the Licensure Examination. There is a significant relationship in the performance both in student teaching and comprehensive examination to the LET performance.
ANALYSIS OF FOOD SECURITY STATUS AMONG RURAL FARMING HOUSEHOLDS IN MUBI NORTH LOCAL GOVERNMENT AREA OF ADAMAWA STATE, NIGERIA
Authors: Haddabi A.S. , Ndehfru N. J , Aliyu A.
Published: July 2020

The study analyzes Food security status among rural farming households in Mubi North local Government Area of Adamawa state, Nigeria. Respondents’ socio- economic characteristics, food security status determinants of household food security and production constraints faced by respondents in achieving food security in the study area were investigated. Data were collected from one hundred and twelve (112) randomly selected rural farmers in six villages of the six (6) selected wards of Mubi North local government area using structured questionnaire. The data were analyzed using descriptive statistics and binary logistic regression analysis. The result revealed that 72.32% of the respondents were male and 75% were married. Majority (72.33%) of the respondents had one form of formal education or the other and with a mean farming experience of 12 years. The respondents were mostly in their economically active age (mean age of 37 years) and cultivate an average of 2.95 hectares of farm land using personal savings. The mean per capita food expenditure per month was estimated to be N6, 205.11 and the value was used as food security index, and majority (74.10%) of the households were food secured in the study area. The result further revealed that educational level, farm size, farming experience and total monthly income of household heads were positively related to households’ food security status, while age of households’ head was inversely related to food security status. The major production constraints to achieving food security status in the study area include; poor access to credit facilities (98%), high cost of agro-chemicals (81%) inadequate and high cost of fertilizer (78%), shortage of labour (77%), poor storage facilities (62%) and inadequate extension visit (51%). The study among others recommended that rural farmers should be trained on farm management efficiency to boost production capacity and they should explore non-farm income to augment their existing income so as to increase their potentials considering that most of the farmers are youths.
BPOM JAMBI MONITORING SYSTEM AGAINST CIRCULATION OF FOOD PRODUCTS WITHOUT CIRCULAR PERMITS IN JAMBI CITY REVIEW ACCORDING TO ISLAMIC LAW
Authors: Marlina Siti
Published: July 2020

Crime is a phenomenon of human life and society, therefore it cannot be released from space and time. The rise and fall of crime rates depends on the circumstances of the community, political conditions, economy, culture and so forth. Based on the results of research at the Jambi BPOM, the problem of crime and violations is a phenomenon that cannot be implemented in people's lives. However, not all people obey the regulations made by the government, many cases of violation of food products without marketing licenses have been successfully disclosed, for information, in 2013 to 2015, a number of 19 cases of drug circulation, cosmetics, traditional medicine and health supplements, food, which does not meet security, benefits, and quality requirements with a nominal value of Rp. 423,769,000 including: 10 cases in the field of medicine, 2 cases in the field, 5 cases in the field of cosmetics and 2 cases in the field of food. successfully revealed and has been submitted to court.