bluuebunny/crossref_metadata_2025 huggingface dataset:
A szegedi boszorkányperek története és forrásai (1726-1744)
Authors: Brandl Gergely
Published: September 2024

A szegedi nagy boszorkányüldözés (1728–1729) a legkiterjedtebb, rövid idő alatt lefolytatott boszorkányok elleni büntetőeljárás-sorozat hazánkban. Kétségkívül kiemelkedő szerepet játszik a szakirodalmi hagyományban, mivel forrásadottsága, annak hozzáférhetősége és hírneve is igen korán felkeltette az érdeklődők figyelmét. A perek mérete (legalább. 25 személy elleni eljárás, 15 halálbüntetés, több száz eljárási résztvevő az eljárásokban), a peres iratokban olvasható démonológiai elemek (pl. külföldi jogforrások jól dokumentált használata, a diabolikus boszorkányhit megjelenése stb.) és a politikai kontextus (pl. a bécsi Magyar Udvari Kancellária vizsgálata, politikai harcok a városi frakciók között) nagymértékben eltérnek más korabeli ügyektől. Sajátos, hogy az esetnek széles nemzetközi recepciója alakult ki (pl. újságcikkek, úti beszámolók, tudományos értekezések A dolgozat egy elméleti részből (1-5. fejezet) és egy mikrotörténeti gyakorlati részből (6-10. fejezet) tevődik össze. Az első rész a kontextust bevezető fejezetet követően három tematikus egységre oszlik: a forráskiadás történetére és elméletére, magyar és nemzetközi historiográfiára, illetve a kutatásmódszertani és fogalmi kérdésekre. A második rész egy hozzávetőlegesen kronologikus felosztást követ: így felosztható a bírósági előzményeknek, az intenzív üldözés időszakának, az üldözés következményeinek és kihatásainak tárgyalására. Dolgozatomban több különböző, mégis összetartozó célt tűztem ki. Ennek egy része a forráskörnyezetet átértelmező álláspontjából fakad, más része pedig új módszertani megközelítésekből. Egyrészt közre adom és bemutatom a szegedi boszorkányüldözések teljes időszakának bírósági forrásait, kritikai kiadásban, a teljességre törekedve. Mindezt úgy, hogy bemutatom azokat a módszertani lehetőségeket, amelyek értelmezésükhöz szükségesek. Mindamellett áttekintem, hogy eddig milyen a szövegkiadási problémák merültek fel és miként lehet megoldani ezeket.
Szerbek Magyarországon a XIV. század végétől a XVI. század elejéig (1389-1526)
Authors: Obradovic Nenad
Published: September 2024

Doktori disszertációnk eredményei által igyekeztünk egységes képet nyújtani a szerb–magyar kapcsolatok késő középkori szakaszáról és azokról a mozgatórugókról, amelyek évszázadokra meghatározták mindkét nép életét. Megállapíthatjuk, hogy az oszmán előrenyomulás felerősítette a szerbek vándorlását, akik Magyarországon kerestek maguknak új hazát. Szent István koronájának országában találva magát az áttelepedett tömeg, vezető rétegének tagjai a bárok és nemesek között, míg a jobbágyok és vlachok a magyar jobbágyok, polgárok és kereskedők között kerestek boldogulást. Előrelépésük legjárhatóbb útját a katonai pályafutás biztosította. Ezért találhatók nagy számban bandériumokban, a zsoldosok között, illetve a huszárok és naszádosok kötelékében. A legelőkelőbbek, a dinasztiák tagjai új állami ideológiát teremtettek, amely a kulturális fennmaradás eszméjén és a hagyományok ápolásán alapult. A szerb állam újbóli felállításának várakozásában néptársaik szemében urlakodók voltak, amit azok egyházi alapításaik körül gyülekezve fejeztek ki. E kulturális központok, amelyek életben tartották a letűnt államiság maradványait, erősítették a vallási buzgalmat, és a már etnikailag megváltozott vidékeken akadályát képezték az aszimilációnak. Ugyan a legkiemelkedőbbek a magyar nemesség soraiba kerülve könnyeben elmagyarosodtak, a kölcsönhatások azonban észlelhetők voltak a mindennapi munka és a szellemi alkotások terén. Magyarországon élve és katonáskodva a szerbek nagymértékben megőrizték kultúrájuk gyöngyszemeit s átmentették az utókorra, amelyből később kicsírázott a modern szerb állam.
From integration to alienation
Authors: Islam Sargi
Published: September 2024

A disszertáció a kurdok identitástudatának XX. századi átalakulására, valamint a mozgalom átalakulását befolyásoló tényezők történeti viszonylatból történő elemzésére fókuszál. A disszertáció azt vizsgálja, hogyan született meg és fejlődött a kurd mozgalom és hogyan reagált erre a török állam a különböző, egymással összefüggő időszakokban. Négy fő elve: oszd meg és irányítsd, a posztbirodalom, a nagy felvilágosodás és a radikális demokrácia rávilágít arra hogy megértsük, hogyan változott és alakult át a török-kurd konfliktus, különös tekintettel a helyi, regionális és globális politikára. A dolgozat hét részre tagozódik, amelyek mindegyike egy adott időszakra vonatkozik. A disszertáció elsődleges célja annak feltárása, hogyan alakult a kurd mozgalom és identitása a huszadik században.
An Extremely Rare Presentation of Mucinous Adenocarcinoma Originating From Meckel Diverticulum Masquerading in a Young Woman With Crohn's Disease
Authors: Fawaris Nada , Shariq Sohail , Elnaggar Mohamed , Kubba Faris , Haria Rashmi
Published: September 2024

Mucinous adenocarcinoma with signet cell features originating from Meckel diverticulum (MD) is an extremely rare primary malignant tumor. A woman in her 30s presented with multiple episodes of vomiting, abdominal pain, and constipation. She had a history of stricturing Crohn's disease and managed well with steroids, azathioprine, and infliximab. This time, a computed tomography scan showed distal ileal small-bowel obstruction. Urgent surgery for a nonsettling small bowel obstruction was performed. MD was incidentally found and was concerning for malignancy. This case report illustrates how this extremely rare malignancy was behaving like Crohn's disease, which delayed the diagnosis and treatment.
AVALIAÇÃO DO PERFIL DE RESISTÊNCIA DE Escherichia coli A ANTIBIÓTICOS ORIUNDAS DA MICROBACIA AGRÍCOLA LOCALIZADA NO NOROESTE DO ESTADO DO RIO GRANDE DO SUL, BRASIL
Authors: Flach Kauane Andressa , Rosa Genesio Mario da , Bones Ubiratan Alegransi , Soriani Hilda Hildebrand
Published: September 2024

A resistência antimicrobiana adquirida por bactérias é um tema central nas discussões sobre meio ambiente e doenças emergentes transmitidas pela água. Portanto, o objetivo deste estudo foi determinar a sensibilidade bacteriana in vitro, especificamente de cepas de Escherichia coli (E. coli) previamente isoladas de Lajeado Pardo, região noroeste do estado do Rio Grande do Sul, Brasil. Cinco antimicrobianos foram testados pelo Teste de Sensibilidade Antimicrobiana (TSA) em amostras isoladas de bactérias e avaliados de acordo com seus perfis de resistência (R) e sensibilidade (S): ampicilina (AMP), amoxicilina-clavulanato (AMC), gentamicina (GEN), cloranfenicol (CLO) e ciprofloxacina (CIP). A análise dos meios de isolamento seletivo (LSB, Colilert e EC) mostrou diferenças estatisticamente significativas entre eles (p<0,05). Portanto, pode-se inferir que o meio seletivo para isolamento bacteriano influenciou os resultados do TSA. O TSA revelou que das 12 cepas bacterianas testadas, nenhuma apresentou o mesmo comportamento em relação aos antibióticos. AMP apresentou a maior taxa de resistência (100,0%), seguido por AMC (67,0%), CIP (50,0%), CLO (50,0%) e GEN (42,0%). A GEN mostrou-se um medicamento eficiente para o tratamento, podendo ser inicialmente classificado como monoterapia satisfatória. Do total das amostras (n=12) dos quatro setores, 83,33% (n=10) apresentaram resistência a múltiplos medicamentos. A elevada taxa de E. coli multirresistente sugere um risco potencial para a saúde pública quando se utiliza água bruta não tratada.
A PANDEMIA DE COVID-19 NOS ESTADOS DAS REGIÕES NORTE E CENTRO-OESTE DO BRASIL
Authors: Costa Nayara Barreto da , Silva Gilcileide Rodrigues da
Published: September 2024

Esta pesquisa objetivou analisar a saúde pública por meio dos registros publicados em forma de decretos acerca da pandemia de COVID-19 nos estados das regiões Norte e Centro Oeste do Brasil considerando as estratégias de controle e normatização dos estados para conter o contágio do vírus no ano de 2020. Como procedimentos metodológicos, realizou-se revisão da literatura acerca da Geografia da Saúde e análise do conteúdo dos decretos oficiais dos estados (392 publicados em 2020) relacionados à COVID-19 no Norte e no Centro-Oeste do país. A análise mostrou que os instrumentos normativos são uma estratégia de controle do território exercida pelas autoridades de cada estado ao adotarem medidas sanitárias às vezes flexibilizadas. Além disso, revelou que as orientações legais de uso do território são correlatas ao número de óbitos na maioria dos estados, de modo que à medida que as ações normativas eram flexibilizadas, o contágio letal aumentava. A pandemia de COVID-19 deixou, portanto, marcas significativas no território, na redefinição dos espaços públicos (controle aéreo, marítimo e terrestre), na perda de centenas de vidas, nos riscos à saúde pública e nos efeitos graves em diferentes setores da economia.
La desigualdad socio económica de los hogares y el proceso de continuidad pedagógica en tiempos de confinamiento
Authors: Quiroga Daniel Esteban , Yuni José Alberto , Meléndez Cecilia Evangelina , Salasar Acosta Luisa María
Published: September 2024

La presente comunicación tiene el propósito de  analizar la interrelación entre la desigualdad socioeconómica y el proceso de continuidad pedagógica mediante un estudio descriptivo–comparativo que tiene como fuente de información dos bases de datos: 1) la Evaluación Nacional del Proceso de Continuidad Pedagógica, relevada en julio del año 2020, por el Ministerio de Educación de la Nación, a través de la Secretaría de Evaluación e Información Educativa; y 2) la Encuesta a Hogares, desarrollada entre el 18 de junio y el 3 de julio del 2020, del Ministerio de Educación de la Nación en conjunto con el Programa de Educación de UNICEF Argentina. Para el tratamiento de los datos se utilizó el programa Statistical Package for the Social Sciences (SPSS). Con el cual se aplicaron filtros para seleccionar el área geográfica que interesa a la investigación, se obtuvieron frecuencias y cruces de los datos que se analizaran. Los resultados revelan que los establecimientos educativos del NOA registran altos niveles de continuidad pedagógica. Sin embargo, la disponibilidad de recursos tecnológicos afectó principalmente a los hogares de alta vulnerabilidad socioeconómica.
Las representaciones de los docentes de una escuela primaria sobre la interdisciplinariedad
Authors: Maturana Alfredo Jesús
Published: September 2024

El presente artículo expone el informe final de la tesis de grado que se realizó en el marco de la Licenciatura en Ciencias de la Educación con orientación en Política y Gobierno de la Educación, que se dicta en la Facultad de Ciencias de la Educación de la Universidad Nacional de Entre Ríos, y cuya defensa se realizó a mediados del 2023.
La complejidad de los tiempos que corren demanda reflexionar en torno a qué enseña la escuela, por qué y cómo lo enseña. Ante la escasa producción sobre la articulación entre interdisciplinariedad y escuela primaria en la Argentina, por medio de dicha investigación -que se llevó adelante en 2022- se buscó reconocer y comprender las representaciones docentes en torno al trabajo interdisciplinario en la escuela primaria.
A partir de la realización de entrevistas semiestructuradas a maestras de una institución escolar de gestión estatal de la ciudad de Vera (Provincia de Santa Fe) en 2022, se intentó entender cuáles son los sentidos que le imprimen quienes enseñan a la interdisciplinariedad, prestando especial atención a la implementación de los Núcleos Interdisciplinarios de Contenidos, documento curricular publicado en 2016 en la Provincia de Santa Fe, como iniciativa del Ministerio de Educación.
Saber de hablar: delimitación de un metalenguaje sobre los géneros orales formales
Authors: Navarro Paula
Published: September 2024

La reflexividad del lenguaje es una propiedad común a las actividades de escritura y oralidad. Sin embargo, se relaciona de forma más recurrente con las prácticas de escritura. Este escrito propone el concepto saber de hablar, cuya delimitación se avizora como posibilidad para conocer y reflexionar acerca de las prácticas lingüísticas en géneros orales formales con instrumentos conceptuales propios, así como proyectar el desarrollo de la capacidad discursivo–textual de las personas a partir de articular instancias de producción textual oral y de reflexión metalingüística. La clase constituye, desde la reflexión de los hablantes, un espacio de teorización por la forma particular que asume el diálogo entre docentes y estudiantes.
Effects of Geographical Conditions on the Physiochemical Properties of Natural Fiber Extracted from the Root of Prosopis juliflora
Authors: Palaniappan Kumarappan , Hanumanthu Jeevan Rao , Singh Sanjay , Prabha Kolluri Aruna , Murthy Soppari Bhanu , Felix dos Santos Felix dos Santos , Minely da Silva Santos Caroliny
Published: September 2024

Biomass-derived Natural Fiber Composites (BDNFCs) are becoming popular in versatile applications in aerospace, biomedical, energy storage automotive, etc. due to their biodegradability, environmental friendliness, and cost-effectiveness. In the current work, root fibers extracted from Prosopis juliflora were selected as the natural fiber. Characterization results for physical and chemical properties on the effects of soil types and moistures in 2 different states of India, i.e. Telangana, and Tamil Nadu on fiber compositions and properties. The results reveals that hemicellulose content of tamilnadu fiber (81 wt%) is less than that of the Telangana fiber (85.7 wt%). Based on analysis results of Fourier Transform Infrared Spectroscopy (FTIR) andThermo Gravimetric Analysis (TGA), Tamil Nadu fiber has the themal stability at 239 °C and maximum degradation temperature at 359.1 °C. Whereas Telangana fiber has thermal stability at 253 °C, and maximum degradation temprature at 387.5 °C. The crystallinity indexes of Tamil Nadu and Telangana fibers were calculated, based on analysis of X-Ray Diffraction (XRD), to be 69.6% and 67.4%, respectively. The crystal sizes of Tamil Nadu and Telangana fibers were 14.38 and 13.21 nm, respectively.
The Effect of Motivation and Perceived Organizational Support on Organizational Citizenship Behavior of The General Secretariat DPR RI Employees Mediated by Job Satisfaction
Authors: Siresia Firosa , Riyanto Setyo
Published: September 2024

This study aims to determine the influence between Motivation and Perceived Organizational Support on Organizational Citizenship Behavior in Employees of the Secretariat General of the DPR RI Mediated by Job Satisfaction. The population in this study consists of 104 Civil Servants in the Bureau of Building and Housing Management of the Secretariat General of the Indonesian House of Representatives (DPR RI). The study uses a saturated sampling method or cencus, thus the entire population is used as the research sample. Data analysis in this study utilizes Structural Equation Modeling (SEM) technique. The results indicate that Motivation has a positive and significant influence on job satisfaction. Perceived Organizational Support has a positive and significant influence on Job Satisfaction. Motivation has a positive and significant influence on Organizational Citizenship Behavior. Perceived Organizational Support has a positive and significant influence on Organizational Citizenship Behavior. Job Satisfaction has a positive and significant influence on Organizational Citizenship Behavior. Motivation has a positive and significant influence on Organizational Citizenship Behavior mediated by Job Satisfaction. Perceived Organizational Support has a positive and significant influence on Organizational Citizenship Behavior mediated by Job Satisfaction. This study contributes novelty as the first research to measure the level of OCB among employees in the Secretariat General of the Indonesian House of Representatives. This study provides novelty as the first research to measure the level of OCB among employess with in the Secretariat General of the Indonesian House of Representatives.
Examination of Darkside of Entrepreneurship among Business Owners in Lagos Nigeria
Authors: Aladejebi Olufemi , Bamkole Peter , Amao-Taiwo Bukola
Published: September 2024

Being an entrepreneur is often viewed as a glamorous and rewarding experience. But behind the scenes, it can be a lonely and stressful journey. With long hours, endless responsibilities, and high expectations, it's not surprising that many founders struggle with mental health issues like depression and anxiety. The study aims to investigate the Darkside of Entrepreneurship among Business Owners in Lagos, Nigeria. The Theoretical framework for the study is the Disappointment theory. The research method used in the study is a detailed survey, which was used to collect data from 412 business owners in Lagos whose businesses were five years and above, operating in different fields. Five Likert scale was used to collect data. It is with the purpose of understanding the causes that lie behind those aspects of entrepreneurship that are less desirable, including economic vulnerability, work overload and even symptoms of mental health disorders. Another significant aspect, which is evident from the investigation, is that individuals aspiring for self-employment are highly stressed with reference to income volatility and chances of business closure. Also, the findings revealed frequent physical-neurological stress factors affecting entrepreneurs. Even while the experts acknowledge many of the factors, such as strategic thinking, having a budget plan, and networking, several individuals indicate that those areas pose challenges in terms of infringing on their health and family. Interestingly, the study also elicits ambivalent attitudes about State aid and the advantages of being part of the chamber of commerce/trade associations. On the basis of these findings, it presents a number of imperative recommendations: increasing the funding and accessibility of financial support services, encouraging organisations to improve work-family balance, establishing an easily understandable framework for regulations and standards, and providing easy access to mental health support services. With these challenges addressed, there is potential to grow the entrepreneurial ecosystem in Lagos, which will benefit all parties interested in buying from local businesses.
Prediction of sensory textures of cosmetics using large amplitude oscillatory shear and extensional rheology
Authors: Lee Hyo-Jeong , Kim Sung Ryul , Kim Byoung Soo , Lee Suhyun , Yi Yoon Ju , Jeon Han Byol , Son Minkyo , Park Kyunghye , Park Chun Ho , Oh Heemuk , Lee Jun Bae , Park Jun Dong
Published: September 2024

We propose a predictive model for various sensory textures utilizing machine learning techniques based on the largest rheology and panel-tested sensory texture database ever assembled. In addition to the conventional rheological parameters typically measured in the cosmetics field, rheological parameters obtained from the large amplitude oscillatory shear (LAOS) sequence of physical processes (SPPs) and extensional rheology analyses are employed as feature variables for the predictive model. These feature variables are chosen to mimic real flow conditions during the usage of cosmetics, such as rubbing and tapping, as they are expected to contain more information related to sensory textures. It has been demonstrated that our prediction model, based on the random forest regression algorithm, can effectively predict five sensory textures: spreadability, thickness, softness, adhesiveness, and stickiness. We investigated the rheological characteristics crucial for determining each sensory texture through permutation and feature importance analyses. The important analysis highlighted the close correlation between rheological parameters from LAOS–SPP, extensional analyses, and sensory textures. By using this correlation, we interpret the perception of each sensory texture in the context of rheology.
Scrutinizing the effect of additive and synergistic antibiotics against carbapenem-resistant Pseudomonas aeruginosa
Authors: Siddiqui Fatima , Zahra Nureen , Zeshan Basit , Khan Ayaz Ali , Sarwar Abid , Aziz Tariq , Alharbi Metab , Alshammari Abdulrahman
Published: September 2024

Pseudomonas aeruginosa causes many infections worldwide. Multidrug-resistant bacteria are mostly watched in hospital-acquired infections and are linked with high mortality rates. This study aims to find a possible cure for P. aeruginosa by using an additive and synergistic combination of drugs. The Carbapenem-resistant P. aeruginosa were isolated and identified by using clinical and laboratory standards institute protocols and their antibiotic susceptibility testing was performed by using disc and well diffusion method. In computational analysis, all of the ligands and proteins were selected and docking was done using PYRX. Hundred samples were taken of isolated Gram-negative bacteria of which 25% were P. aeruginosa. Additive combinations (meropenem [MPM] + tobramycin [TOB] was 100% sensitive and imipenem + TOB was also 100% sensitive) and synergistic combinations (MPM + ciprofloxacin were 90% sensitive and amikacin and imipenem) were 100% sensitive according to CLSI protocol. In computational analysis, TOB gave the highest binding energy of −11.4, whereas MPM shows a binding energy of −9.3. In conclusion, Additive and synergistic combination of drugs showed good antibacterial activity against Pseudomonas aeruginosa. Hence it can be used as a good treatment option for P. aeruginosa.
Complicated diverticulitis with colovesical fistula and bladder abscess formation in pregnancy: a case report
Authors: Huang Shirley , Chen Jiahua , Rivera Natalie , Ram Kavitha T. , Minkoff Howard L.
Published: September 2024

Objectives

Diverticulitis, characterized by inflammation or infection of diverticula, is rarely observed during pregnancy due to its association with elderly patients. Limited literature exists regarding its diagnosis and management in pregnant patients, especially in the setting of complications.

Case presentation

This paper presents a case of a 37-year-old multiparous woman diagnosed with complicated diverticulitis, including colovesical fistula and bladder abscess formation.

Conclusions

This paper highlights the importance of considering diverticulitis in pregnant patients with abdominal pain, the need for timely diagnosis, and the significance of multidisciplinary care.
Novel homozygous mutation in the human RAX homeobox gene in a patient with bilateral anophthalmia and severe endocrine dysfunction – a case report and literature review
Authors: El-Nahry Yasmin H.A. , Bardinet Victor , Bührer Christoph , Henrich Wolfgang
Published: September 2024

Objectives

Childhood visual impairment due to congenital malformation leads to severe handicaps and lifelong consequences for the affected child. Congenital anophthalmia remains a rare condition marked by a child born with an empty eye socket. The embryonic plant of the eye occurs approximately on day 22 of intrauterine development and ends within the first trimester of pregnancy. Mutations in the RAX gene located on chromosome 18 (# 601881) cause a spectrum of head malformations, ranging from isolated microphthalmia/anophthalmia with cleft lip and palate to complex brain malformations.

Case presentation

Here, we present a child’s case diagnosed with bilateral anophthalmia at 33 weeks of gestation. The newborn was delivered vaginally with a RAX-gene-linked syndrome. Besides craniofacial malformations (bilateral anophthalmia, craniofacial hypoplasia, bilateral cleft lip), the female child had severe endocrine dysfunction (congenital hypopituitarism and diabetes insipidus) postnatal that required specialised monitoring and clinical management. Our case study reports a novel homozygous autosomal recessive non-sense mutation (c.106G>T; p.Glu36Ter) of the RAX gene. This is the first description of this pathogenic gene variant in the literature.

Conclusions

Early and precise sonography is crucial in detecting these conditions on time to prepare postpartum care and avoid delays in optimal clinical treatment for the affected child. This case report aims to raise the scientific community’s awareness about this rare genetic syndrome, showing an individualised two-year follow-up program that could help guide physicians and future parents of affected children.
Assessment of antimicrobial activity and methyl orange dye removal by Klebsiella pneumoniae-mediated silver nanoparticles
Authors: Desai Reema , Yadav Virendra Kumar , Patel Bhakti , Rami Esha , Almoallim Hesham Saleh , Ansari Mohammad Javed , Choudhary Nisha , Sahoo Dipak Kumar , Patel Ashish
Published: September 2024

The synthesis of silver nanoparticles (AgNPs) using bacteria is more interesting because of their non-toxic, biocompatible, environmentally friendly, and cost-effectiveness. In the present research work, AgNPs were synthesized by Klebsiella pneumoniae in two steps: first, K. pneumoniae was grown in nutrient broth, followed by mixing of bacterial supernatant and silver nitrate aqueous solution in an optimized ratio. The synthesized AgNPs were thoroughly analyzed using analytical instruments for a detailed investigation. The absorption peak observed using UV-visible spectrophotometry at 464 nm indicated the development of AgNPs, while the characteristic bands for the AgNPs by infrared spectroscopy were observed in the region of 500–4,000 cm−1. Morphological examination via field emission SEM unveiled spherical-shaped AgNPs whose sizes varied from 22.25 to 47.99 nm, along with high aggregation. The crystallinity nature of the synthesized AgNPs was demonstrated by X-ray diffraction, which revealed major intensity peaks at 2θ values of 27.6°, 31.9°, and 46°. AgNPs showed 26.6% of methyl orange dye removal within 50 min. The antibacterial activities against Bacillus cereus, Bacillus megaterium, Serratia marcescens, and Staphylococcus aureus showed maximum zones of inhibition, i.e., 14 mm (10 mg·mL−1), 16 mm (5 and 10 mg·mL−1), 13 mm (5 and 10 mg·mL−1), and 12 mm (10 mg·mL−1). Therefore, the bacterial-synthesized AgNPs exhibited potential application in the field of biomedicine, which may be further used against various other pathogens.
Molecular and Functional Alterations in the Cerebral Microvasculature in an Optimized Mouse Model of Sepsis-Associated Cognitive Dysfunction
Authors: Ávila-Gómez Paulo , Shingai Yuto , Dash Sabyasachi , Liu Catherine , Callegari Keri , Meyer Heidi , Khodarkovskaya Anne , Aburakawa Daiki , Uchida Hiroki , Faraco Giuseppe , Garcia-Bonilla Lidia , Anrather Josef , Lee Francis S. , Iadecola Costantino , Sanchez Teresa
Published: September 2024

Systemic inflammation has been implicated in the development and progression of neurodegenerative conditions such as cognitive impairment and dementia. Recent clinical studies indicate an association between sepsis, endothelial dysfunction, and cognitive decline. However, the investigations of the role and therapeutic potential of the cerebral microvasculature in sepsis-induced cognitive dysfunction have been limited by the lack of standardized experimental models for evaluating the alterations in the cerebral microvasculature and cognition induced by the systemic inflammatory response. Herein, we validated a mouse model of endotoxemia that recapitulates key pathophysiology related to sepsis-induced cognitive dysfunction, including the induction of an acute systemic hyperinflammatory response, blood–brain barrier (BBB) leakage, neurovascular inflammation, and memory impairment after recovery from the systemic inflammation. In the acute phase, we identified novel molecular (e.g., upregulation of plasmalemma vesicle-associated protein, PLVAP, a driver of endothelial permeability, and the procoagulant plasminogen activator inhibitor-1, PAI-1) and functional perturbations (i.e., albumin and small-molecule BBB leakage) in the cerebral microvasculature along with neuroinflammation. Remarkably, small-molecule BBB permeability, elevated levels of PAI-1, intra-/perivascular fibrin/fibrinogen deposition, and microglial activation persisted 1 month after recovery from sepsis. We also highlight molecular neuronal alterations of potential clinical relevance following systemic inflammation including changes in neurofilament phosphorylation and decreases in postsynaptic density protein 95 and brain-derived neurotrophic factor, suggesting diffuse axonal injury, synapse degeneration, and impaired neurotrophism. Our study serves as a standardized mouse model to support future mechanistic studies of sepsis-associated cognitive dysfunction and to identify novel endothelial therapeutic targets for this devastating condition.
Vzestupy a pády komunistického soudce, důstojníka a politika Zdeňka Číhala (1921–2002)
Authors: Pažout Jaroslav
Published: September 2024

The study is analyzes the fate of Zdeněk Číhal, who became the chairman of the District Court in Žatec in 1952 and the following year the chairman of the Regional Court in Liberec. From 1957, he served as the chief of the main administration of military courts and the deputy of the Minister of Justice. In the spring of 1968, he was relieved of his duties because, from the position of the fi rst deputy of the Minister of Justice, he obstructed judicial rehabilitation, and even in 1967, he also tried to infl uence court decisions. Already in October of the same year, he was nevertheless appointed administrator of the military district in Mimoň and, from February 1969, also of the military district of Mladá. In February 1970, he became the chairman of the District National Committee in Liberec. However, in the spring of 1970, the leading authorities of the Communist Party discovered that, before his dismissal from offi ce in 1968, he had recorded an interview with the editors of the Czechoslovak Radio about the issues of judicial independence and the deforming 1950s, in which he was supposed to defame the Communist Party and some of its offi cials. At the same time, he handed over secret documents to the editors. This was followed by his removal from the position of chairman of the district national committee and expulsion from the Communist Party. After 1989, he tried unsuccessfully to rehabilitate himself.
Architektonická stránka vybraných drážních budov Jihoseveroněmecké spojovací dráhy mezi lety 1854 a 1909
Authors: Tarant Jiří
Published: September 2024

The study is based on the diploma thesis „When the train arrived - the history of the railway from Pardubice/Pardubitz to Liberec/Reichenberg between 1854 and 1909“. It aimed to connect architectural-historical and technical research probes into a single narrative. The period procedures, mechanisms, regularities and specifi cs that characterized the selected railway were defi ned in the text by the selected objects. The original concept of the diploma thesis was to also conduct fi eld research and capture the oldest surviving elements of the track. Due to the amount and variety of archival material, this plan has been modifi ed and reduced from its original scope. In the said qualifying work, it was refl ected in the photographs of the current state of the dispatch building in Liberec and Hodkovice nad Mohelkou/Liebenau. Especially in the case of the Liberec railway station, the potential of the archive fund was far from exhausted. There is a relatively large amount of material for study – especially technical constructions – and they open up further possibilities for research.
Efektivitas Pembelajaran Hybrid pada Mata Kuliah Produksi Adibusana Mahasiswa Pendidikan Tata Busana Universitas Negeri Semarang
Authors: Novitasari Siska , Rachmawati Rina
Published: September 2024

Adanya pandemi covid-19 menyebabkan semua bidang menjalankan kegiatan secara online termasuk juga pada bidang pendidikan. Universitas Negeri Semarang merupakan salah satu universitas yang menjalankan pembelajaran secara hybrid dimana mahasiswa yang mengikuti pembelajaran ialah 50% dari jumlah kelas. Tujuan dari penelitian ini ialah untuk mengetahui efektivitas pembelajaran hybrid mahasiswa Pendidikan Tata Busana dalam Mata Kuliah Produksi Adibusana. Populasi dalam peneliian ini ialah mahasiswa yang telah menempuh Mata Kuliah Produksi Adibusana secara hybrid, yaitu mahasiswa Pendidikan Tata Busana Angkatan 2020 Fakultas Teknik Universitas Negeri Semarang yang berjumlah 73 mahasiswa. Teknik pengambilan sampel yang digunakan ialah proportional random sampling dengan nilai kritis 10% menghasilkan 42 responden. Metode penelitian ini adalah deskriptif kuantitatif dengan teknik analisis faktor. Hasil dari penelitian ini ialah motivasi belajar merupakan faktor paling tinggi dalam efektivitas pembelajaran hybrid, sebesar 28,78%,  selanjutnya metode mengajar sebesar 26,57%, kerjasama sebesar 15,55%, sarana dan prasarana sebesar 5,88%, dan waktu belajar sebesar 5,33%.
Research on willow furniture design based on Kano-AHP and TRIZ
Authors: Chen Yanming , Liu Mingbin , Xu Jinyang , Yu Shun , Chen Longping
Published: September 2024

Willow wood furniture has become one of the most popular types of wood furniture in the Chinese furniture market. Research was undertaken to solve the pain points of product design and meet the requirements of green development. Firstly, the Kano model was used to classify user requirements. Secondly, the Analytic Hierarchy Process was used to calculate each design factors’ comprehensive weights, ensuring consistency between the design objectives and user requirements. Thirdly, the TRIZ contradiction matrix was used to identify and solve engineering difficulties in the design process. During the design process, the Kano-AHP-TRIZ was combined to realize a scientific design strategy that combines qualitative and quantitative approaches. The results showed that the design scheme of willow furniture based on user requirements had consistency, matching, and effectiveness with the furniture market development trend, which makes the furniture design process more scientific and rigorous. It also provided a new research perspective and design strategy for the innovative development of the furniture industry.
Characterization of banana and sisal fiber fabrics reinforced epoxy hybrid biocomposites with cashew nut shell filler for structural applications
Authors: Sathishkumar T. P. , Nagarajan Rajini , Ismail Sikiru O. , Pruthiviraaj V. V. , Prabakaran A. B. , Saravanakumar A. , Krishnan Kumar , Mohammad Faruq , Ali Mohd Sajid
Published: September 2024

Mechanical, thermal, and water absorption properties of banana fiber and sisal fiber-reinforced epoxy biocomposites were evaluated with and without cashew nut shell (CNS) filler, either separately, or as hybrid biocomposites. Bidirectional woven mats were used to make composites by compression molding. The CNS filler content was 5% to 10%. Adding CNS filler of up to 5% improved the mechanical and thermal properties. Further increases in filler content above the threshold value diminished their mechanical properties due to poor dispersion and increased porosity. The maximum tensile and flexural strength were found as 43 and 92 MPa. The highest impact strength was obtained with the hybrid biocomposites with 5% filler. This was attributed to the toughening effect of phenolic compounds in the CNS. In addition, the thermal stability of the biocomposites was influenced by filler content. The biocomposites exhibited varying water absorption capacities as the filler content increased with the water uptake. Scanning electron microscopy (SEM) images showed the microsurface of the fractured samples and their interfacial bonding, fiber pull-out, and fracture. However, increasing filler content in the biocomposite reduced the filler pull-out and led to fiber breakage.
Supercritical carbon dioxide extracts of Schinus terebinthifolia fruits and their utilization against microbial illness, lipase, and butyrylcholinesterase activities in vitro
Authors: Alghonaim Mohammed Ibrahim , Alsalamah Sulaiman A. , Alshammari Amal Naif , Selim Samy
Published: September 2024

The extraction methods used to obtain natural products face some problems, such as solvent toxicity, high extraction time, and low yields. Supercritical carbon dioxide fluid extraction (SFE-CO2) is an encouraging extraction system for obtaining high-yield of natural extracts. In this work, Schinus terebinthifolia fruits were extracted via SFE-CO2 using two conditions: A (static extraction) (SE) for 15 min, followed by dynamic extraction (DE) for 45 min, and B (without SE but with DE for 60 min). The extract yield was 0.205 g and 0.236 g via condition A and B, respectively. High-performance liquid chromatography assessment revealed the occurrence of several constituents with high quantities in the extract at condition B. The well diffusion test showed inhibition of 26 ± 0.1, 25 ± 0.2, 29 ± 0.1, 33 ± 0.2, 27 ± 0.1, and 8.0 ± 0.1 mm zones using the extract at condition B, while at condition A there were low inhibition zones towards Staphylococcus aureus, Pseudomonas areginosa, Bacillus subtilis, Escherichia coli, Candida albicans, and Aspergillus niger, correspondingly. Lipase (obesity stimulant) and butyrylcholinesterase (Alzheimer stimulant) were inhibited by the extract at condition B with IC50 quantities of 27.03 and 4.83 μg/mL, while it was 37.45 and 17.57 μg/mL, respectively at condition A.
Ultrasound-alkali-assisted isolation of cellulose from coconut shells
Authors: Mohan Pavitra , Yusof Nor Saadah Mohd , Thomas Sabu , Abd Rahman Nor Mas Mira
Published: September 2024

This research explored the isolation of cellulose from coconut shells using ultrasound. It involved two types of cellulose isolation: alkali and bleached cellulose (ABC) and ultrasound-alkali-assisted isolated cellulose (UAIC). The products were characterized using various techniques, including attenuated total reflection-Fourier transform infrared spectroscopy (ATR-FTIR), X-ray diffraction analysis (XRD), thermogravimetric analysis (TGA), and field emission scanning electron microscopy (FESEM). The ATR-FTIR results confirmed the effective removal of lignin and hemicellulose in the ABC and UAIC samples. Field emission scanning electron microscopy analysis revealed the production of micro-sized cellulose. The TGA and XRD results showed improved thermal stability and crystallinity in ABC and UAIC, attributed to the elimination of non-cellulosic constituents. However, the thermal stability and crystallinity of UAIC were lower compared to ABC, likely due to the cavitation effect caused by sonication. The findings suggest that ultrasonication is an efficient and promising method for isolating cellulose.
Implementación y Optimización de la Automatización de Procesos Robóticos (RPA) en diferentes sectores: Estudios de Caso y Revisión
Authors: Quiñones Nieto Yamil Alexander , Jurado Calle Gerardo Enrique
Published: September 2024

En el sector financiero, la eficiencia operativa y la excelencia en el servicio al cliente son fundamentales. La Automatización de Procesos Robóticos (RPA) ha surgido como una solución tecnológica clave para abordar estos desafíos, ofreciendo la automatización de tareas repetitivas y manuales. Este artículo explora el papel de la RPA en la optimización de procesos y la mejora del soporte técnico en empresas financieras. Se presentan varios estudios de caso que ilustran cómo la RPA puede ser implementada exitosamente para mejorar la eficiencia operativa y la calidad del servicio. Además, se analiza el papel crucial de las empresas de consultoría en tecnología financiera en la implementación efectiva de la RPA, proporcionando apoyo técnico y estratégico para maximizar los beneficios de esta tecnología. Este artículo destaca la importancia de la colaboración entre la tecnología y el soporte técnico en el sector financiero, ofreciendo una visión integral sobre cómo la RPA puede transformar la eficiencia operativa y la calidad del servicio en las instituciones financieras.
Predicción de caudal del río Chira usando redes neuronales artificiales
Authors: Alvarado-Silva Raul , Chaccara-Cruz Giovanni
Published: September 2024

En este artículo se propone un modelo de redes neuronales artificiales para la predicción del caudal del río Chira, específicamente utilizando el modelo LSTM (Long Short-Term Memory), diseñado para el procesamiento de secuencias de datos como las series temporales. Este modelo es particularmente adecuado para esta tarea debido a su capacidad para capturar dependencias a largo plazo en los datos, lo cual es esencial cuando se trabaja con información hidrológica variable. Basándonos en datos registrados y obtenidos de la Plataforma Nacional de Datos Abiertos, buscamos desarrollar un sistema que permita estimar el nivel de caudal del río Chira con alta precisión. Este sistema será de gran utilidad no solo para los pobladores cercanos al río, quienes podrán recibir alertas tempranas sobre posibles crecidas y así tomar las medidas necesarias para protegerse, sino también para ingenieros especializados en la rama hidrológica. Los ingenieros podrán utilizar estas predicciones para planificar y gestionar mejor los recursos hídricos, realizar estudios de impacto ambiental y diseñar infraestructuras más eficientes y seguras. Además, la implementación de este modelo contribuirá a la investigación científica en el campo de la hidrología y las ciencias ambientales, proporcionando una herramienta avanzada para el análisis de patrones de flujo de agua y el comportamiento del río Chira bajo diversas condiciones climáticas y estacionales.
Modelo de gestión de la innovación educativa en la universidad utilizando TIC
Authors: Vera-Pomalaza Virginia , Campos-Macha Raquel E.
Published: September 2024

La innovación educativa es un proceso que proporciona a los docentes la posibilidad de mejorar continuamente en aspectos relacionados al aprendizaje de los estudiantes. Este proceso requiere de la motivación para activarlo y estrategias de enseñanza y aprendizaje sujetas a los cambios constantes de las sociedades en el mundo. Por ello la universidad como ente formador de profesionales que se enfrentan a esos cambios constantes de la sociedad retan a los docentes y sus directivos a crear e innovar en diferentes procesos de enseñanza y aprendizaje. Para asumirlo es necesario un trabajo en equipo y utilizar un soporte que le permita al innovador o grupo de innovadores organizarse y obtener apoyo en los momentos más cruciales mediante la resolución de problemas como uno de los retos en la formación del futuro profesional, tales como experiencias pasadas, consulta con expertos o personas que pasaron por los mismos casos y otros. El modelo de gestión de innovación educativa en la universidad utilizando tecnología de información y comunicaciones tiene como objetivo apoyar a todos los docentes, alumnos y personal académico de la universidad a desarrollar proyectos de innovación educativa siguiendo una serie de pautas, procesos, metodologías relacionadas con la innovación, de esta manera la universidad pueda hacer visible los trabajos que se están realizando, apoyarlos, estudiarlos y tener la posibilidad de elegir la mejor forma de gestión a realizar.
Integrative approach of plyometrics and nutritional strategies on vertical jump performance in elite targetball players
Authors: Murugan Sembaiyan Kalai , Krishnan Renganathan Mohana , Sanjaykumar Swamynathan , Stadnyk Svitlana , Okun Daria
Published: September 2024

Purpose: This study aimed to evaluate the impact of combining plyometric training with a structured nutritional plan on the vertical jump height of elite Targetball players. It also examined the correlation between improvements in jump height and various factors, including the provided nutritional support, to determine whether this combined approach leads to superior outcomes compared to plyometric training alone.

Material and Methods: Thirty-six elite male Targetball players from Tamil Nadu, India, aged 20 to 25 years, were randomly assigned into three groups: Plyometric Training Only (PTO), Plyometric Training with Nutritional Support (PTNS), and a control group (CG). Over a 12-week period, the PTO group engaged solely in plyometric exercises, while the PTNS group received the same plyometric regimen plus a structured nutritional plan focusing on protein intake and hydration. The control group received no specific training or nutritional intervention. Vertical jump height was assessed using the countermovement jump (CMJ) test. Data were analyzed using ANOVA to compare jump heights across groups before and after the intervention and Pearson correlation analysis to examine relationships between jump height improvements and nutritional support, with significance set at p < 0.05.

Results: The ANOVA revealed no significant differences in pre-test vertical jump heights among the groups (F = 0.56, p > 0.05). However, significant differences were observed post-test (F = 54.79, p < 0.05), with the PTNS group showing the greatest improvement in jump height compared to the PTO and CG groups. Correlation analysis indicated that height was strongly associated with jump height (r = 0.859, p < 0.05), while protein intake and water consumption had weaker correlations.

Conclusions: Combining plyometric training with a structured nutritional plan significantly enhances vertical jump height compared to plyometric training alone or no intervention. The results underscore the benefits of integrating nutritional strategies, especially focusing on adequate protein intake and hydration, to optimize the effectiveness of plyometric training. The findings highlight the importance of a holistic approach to athletic training that includes both physical and nutritional elements to maximize performance and reduce injury risks
The Origins and Figurative Embodiment of the Mikhail Lermontov’s Imperial Consciousness
Authors: Kiseleva Irina , Potashova Ksenia
Published: September 2024

The purpose of this article is to reveal the historical concept of M. Y. Lermontov in the context of the ideas of his time, and to identify the historiosophical motives of his work. The central place is given to the understanding and genesis of the image of Russia as a country of the North and Russians as “sons of midnight.” The connection of Lermontov’s texts with the “Tale of Bygone Years,” the odes of G. R. Derzhavin, the works of his contemporaries A. F. Merzlyakov, V. A. Zhukovsky, A. S. Pushkin is traced in the context of assimilation of the statehood ideas, an understanding of the historical place of Russia as a Christian empire, an awareness of the specifics of Russia's relations with the Eastern and European world. The article presents the characteristics of the state sentiments in the 1830s associated with the understanding of the tense political situation on Russia’s European and North Caucasian borders, an awareness of the importance of national history and the rise of national consciousness, the assertion of the idea of Russia’s beneficial influence for the socio-cultural development of the peoples taken under its patronage. Lermontov is the heir of the literary and cultural tradition proper, dating back to the Old Russian literature with its ideas of Orthodox statehood and God-chosen Russia as the successor of the Byzantine Christian Empire. The article focuses on poems related to the Patriotic War of 1812, as well as the actions of the Russian army in the Caucasus. The “Borodino Cycle” and Lermontov’s “oriental text” are intertwined in a host of patriotic motives conditioned by the state character of Lermontov’s historical thinking. In Lermontov’s work, cultural references to the idea of Moscow as the Third Rome are indicated. The poet is represented as the bearer of the imperial consciousness, which is based on the dominance of the idea of Russia as an Orthodox power. The actualization of imperial ideas in Lermontov’s work is connected with his vivid perception of the interaction between Russia and the West (Europe), and Russia and the East (Caucasus) in his times.