bluuebunny/crossref_metadata_2025 huggingface dataset:
Failure of endoscopic management of ureteral strictures is due to ureteroscopic lithotripsy as a cause and longer length of stricture
Authors: Sugino Teruaki , Taguchi Kazumi , Hamamoto Shuzo , Okada Tomoki , Isogai Masahiko , Tanaka Yutaro , Unno Rei , Fujii Yasuhiro , Hamakawa Takashi , Ando Ryosuke , Okada Atsushi , Yasui Takahiro
Published: August 2020

Background

Ureteroscopic lithotripsy is a common treatment for middle and lower ureteral stones. Although effective and minimally invasive, this technique might cause significant complications, including postoperative ureteral strictures, which occur in 1–4% of patients after ordinary ureteroscopic lithotripsy and in 7.8–24% when lithotripsy is performed for impacted stones. The main purpose of the management of ureteral strictures is to improve hydronephrosis and protect renal function. However, factors that influence the success rate of the endoscopic management of US (e.g., the cause and length of stricture, the duration of hydronephrosis, surgical management technique, and the number of placed ureteral stents) are controversial. The aim of this study was to investigate factors determining the outcomes of endoscopic management for stone-related ureteral stricture.
Methods

This multi-center case series study was performed at one of the highest-volume centers and the affiliated institutions in Japan. Data of patients who underwent endoscopic surgery for ureteral stricture from January 2016 to March 2019 were retrospectively analyzed. Laser incision and/or balloon dilation were performed for management; single or double stents were placed at the end of the surgery. Treatment success was defined as improvement in hydronephrosis status.
Results

Nineteen patients were treated for stone-related ureteral stricture. Hydronephrosis successfully improved in 12 patients (63.2%). All seven patients with failed endoscopic management had ureteroscopic lithotripsy-related stricture, whereas 3/12 (25.0%) and 7/12 (58.3%) patients with ureteroscopic lithotripsy-related stricture and impacted stone-related stricture, respectively, underwent successful endoscopic treatment (P = 0.004). Stricture length > 15 mm was observed in five patients (71.4%) with failed management, two patients (16.6%) with successful management (P = 0.046), 7/10 patients (70.0%) with ureteroscopic lithotripsy-related stricture, and 1/7 patients (14.3%) with impacted stone-related stricture (P = 0.049). Among patients with ureteroscopic lithotripsy-related stricture and impacted stone-related stricture, both laser incision and balloon dilation were performed in 5/10 (50.0%) and 2/7 (28.6%) patients (P = 0.874) while double stents were placed in 5/10 (50.0%) and 5/7 (57.1%) patients (P = 0.874), respectively.
Conclusions

Ureteroscopic lithotripsy as a cause and stricture length > 15 mm could strongly affect the success rate of endoscopic management of ureteral stricture. In such cases, reconstructive management should be considered in the early stages.
Frequency Tracking Of A Prototype Elliptical RF Cavity
Authors: DAS RAJDIP
Published: August 2020

Remarkable development with the use of microwave cavity has occurred during the last two to three decades, particularly in portable correspondence, TV transmission, modern/local applications, satellite correspondence, telemetry, RADAR/navigational guides, and so forth. This quick improvement inside the microwave which of computerized advances has synergized, bringing about further quickened rate. The paper reports primarily on the frequency tracking system probably be coupled with radio frequency (RF) cavity. For the creating and testing of the tracking system, we have used phase detectors and loop filters throughout. The quality of the tracking system and thus the underlying scanning results were seen to help the realistic tests.
Adjuvant Treatment Approach in Primary Apocrine Adenocarcinoma Presenting With Axillary Mass: A Case Report
Authors: Bulut Gulcan , Senyurek Sukran , Eren Remziye
Published: August 2020

Background: Primary apocrine sweat gland adenocarcinoma is a very rare tumor. Apocrine carcinoma is a high incidence of local recurrence and lymph node metastasis. When the location of the tumor is axilla, it should be differentiated from occult breast cancer. Surgery is the first step in primary apocrine cancer treatment. However, there is no clear consensus about adjuvant part of treatment. In this case, we presented a 60-year old female patient with primary apocrine sweat gland carcinoma of the axilla. To our knowledge, this is the first case in the literature to use combined adjuvant radiation therapy and anti-estrogen therapy.Case presentation: A 60-year old female patient presented with a slowly growing mass in the right axilla. The patient was examined by a surgeon and there was suspected to be metastasis from breast cancer diagnosed in September 2017. Axillary localized apocrine carcinoma was differentiated from occult breast cancer by pathological findings. For this reason, the patient was operated only an axillary dissection operation. Operated patient with axillary apocrine carcinoma was treated with radiotherapy. As a result of pathological evaluation of the tumor, tamoxifen was added to the treatment when the hormone receptor was positive.Conclusions: The pathological features must be evaluated in detail for targeted treatment, which should be ap-plied with a multidisciplinary approach. Based on this case presentation and literature, adjuvant radiotherapy can be recommended to reduce the risk of local recurrence and hormone-therapy to reduce distant recurrence in patients with hormone-receptor positive primary apocrine carcinoma.
Neutrophil-lymphocyte Ratio as a Predictor of Delirium in Older Hospitalized Patients: A Prospective Cohort Study
Authors: Zhao Yanli , Yue Jirong , Lin Taiping , Peng Xuchao , Xie Dongmei , Gao Langli , Shu Xiaoyu , Wu Chenkai
Published: August 2020

Background: Delirium is a common neuropsychiatric syndrome in older hospitalized patients. Previous studies have suggested that inflammation and oxidative stress contribute to the pathophysiology of delirium. However, it remains unclear whether neutrophil-lymphocyte ratio (NLR), an indicator of systematic inflammation, is associated with delirium. This study aimed to investigate the value of NLR as a predictor of delirium among older hospitalized patients.Methods: We conducted a prospective study of 740 hospitalized patients aged 70 years at the West China Hospital of Sichuan University. Neutrophil and lymphocyte counts were collected within 24 hours after hospital admission. Delirium was assessed on admission and every 48 hours thereafter. We used the Receiver operating characteristic analysis to assess the ability of the NLR for predicting delirium. The optimal cut-point value of the NLR was determined based on the highest Youden index (sensitivity + specificity - 1). Patients were categorized according to the cut-point value and quartiles of NLR, respectively. We then used logistic regression to identify the unadjusted and adjusted associations between NLR as a categorical variable and delirium. Results: The optimal cut-point value of NLR for predicting delirium was 3.626 (sensitivity: 75.2%; specificity: 63.4%; Youden index: 0.386). The incidence of delirium was significantly higher in patients with NLR >3.626 than NLR ≤3.626 (24.5% vs 5.8%; P<0.001). Significantly fewer patients in the first quartile of NLR experienced delirium than in the 3rd (4.3% vs 20.0%; P<0.001) and 4th quartiles of NLR (4.3% vs 24.9%; P<0.001). Multivariable logistic regression analysis showed that NLR was independently associated with delirium.Conclusions: NLR is a simple and practical marker that can predict the development of delirium in older hospitalized patients.
Comparison of somatic STAT3 and STAT5b gene mutations between Felty's syndrome and T-cell large granular lymphocytic leukemia with rheumatoid arthritis
Authors: Gorodetskiy Vadim R. , Sidorova Yulia V. , Kupryshina Natalia A. , Vasilyev Vladimir I. , Probatova Natalya A. , Ryzhikova Natalya V. , Sudarikov Andrey B.
Published: August 2020

Objectives Approximately 15% of patients with T-cell large granular lymphocytic leukemia (T-LGLL) have rheumatoid arthritis (RA). RA-associated T-LGLL with low large granular lymphocyte counts (aleukemic presentation) and Felty's syndrome (FS) have indistinguishable clinical presentations. These disorders are distinguished by T-cell clonality which is observed in T-LGLL but not in FS. Activating somatic mutations in the signal transducer and activator of transcription 3 (STAT3) and 5 (STAT5b) genes are involved in T-LGLL pathogenesis; however, the prevalence of these mutations in FS is unknown.Methods Based on the rearrangements of T-cell receptor (TCR) gamma and beta genes according to the BIOMED-2 protocol, we examined T-cell clonality in 81 patients with RA and unexplained neutropenia. We stratified these patients by the presence or absence of T-cell clonality, respectively, into 2 groups: RA-associated T-LGLL (56 patients) and FS (25 patients). Allele-specific TaqMan Real-Time polymerase chain reaction assay was employed to detect point somatic mutations in STAT3 and STAT5b genes in each group.Results Mutations of the STAT3 gene were detected in none of the 24 cases of FS and in 22 of 56 cases of RA-associated T-LGLL (39%) (p < 0.001). No mutation of the STAT5b gene was detected in any of the patients in each group.Conclusions Although further data are needed, our results suggest that activating somatic mutations in STAT3 and STAT5b genes are not involved in the pathogenesis of FS.
Physician distribution across China’s cities: Regional variations
Authors: Yu Xuexin , Zhang Wei , Liang Jersey
Published: August 2020

Background Distribution of physicians is a key component of access to health care. Although there is extensive research on urban-rural disparities in physician distribution, limited attention has been directed to the heterogeneity across urban areas.This research depicts variations in physician density across over 600 cities in the context of China’s rapid urbanization. Methods Data came from National Census Surveys and China statistical yearbooks, 2000-2003, and 2010-2013. Cities were characterized in terms of not only administrative level but also geographic regions and urban agglomerations. We analyzed variations in physician supply by applying generalized estimating equations with an ordinal logistic linking function. Results Although overall physician density increased between 2003 and 2013, with population and socioeconomic attributes adjusted, physician density actually declined in urban China. On average, urban districts had a higher physician density than county-level cities, but there were regional variations. Cities in urban agglomerations and those outsides did not differ in physician density.Conclusion Despite the improved inequality between 2003 and 2013, the growth in physician density did not appear to be commensurate with the changes in population health demand. Assessment in physician distribution needs to take into account heterogeneity in population and socioeconomic characteristics.
Comprehensive Analysis of Potential Genes in Brain Metastasis of Breast Cancer
Authors: Huang Kanghua , Guo Qiuyi , Luo Xueying , Li Feng , Gao Rui , Zhou Zihan , He Jinsong
Published: August 2020

Background Patients with brain metastasis of breast cancer have low quality of life, are prone to bad emotions such as anxiety and depression, and have poor prognosis. It is particularly important to find therapeutic targets for this type of patients. Methods The differential genes between breast cancer patients with brain metastasis and simple breast cancer were screened by GSE125989 of GEO database, and the hub gene affecting the prognosis of breast cancer patients were identified by bc-GenExMiner database, and then the hub gene were analyzed comprehensively by STRING database and DAVIA database.Results We found that OPA1 is a potential indicator for predicting the prognosis of Asian patients with breast cancer with brain metastasis.OPA1 is involved in affecting the composition and function of mitochondria, affecting energy supply, and is also related to the FOXO signal pathway. Conclusions The effect of OPA1 on mitochondrial energy supply and its participation in FOXO signaling pathway may lead to brain metastasis of cancer. OPA1 is a potential therapeutic target for the treatment of brain metastasis of breast cancer, and further research is needed.
To What Extent Does Human Capital Development Impact Economic Growth? Empirical Evidence From Nigeria.
Authors: Abubakar Attahir Babaji , Bala Ahmad Sani , Musa Abdullahi Aliyu
Published: August 2020

This study examined the effect of human capital development on the economic growth of Nigeria. In achieving this, the human capital variables of education and health care were included in the study. The study employed the Autoregressuve and Distributive Lag (ARDL) model to annual series covering the period 1983 to 2018 for analysis. The findings of the study revealed the presence of a long-run association among the stua﻿dy variables. Further, it was discovered that in both the short and long run, both components of human capital development produce a positive effect on economic growth, although the effect of education appeared to be larger. The study emphasized the need for policymakers to enhance both access to and quality of health care and education with a view to stimulating the economic growth of Nigeria.
The Association Between Deficiency of Nutrient Intake on Resting Metabolic Rate in Overweight and Obese Women: A Cross-Sectional Study
Authors: Sajjadi Seyedeh Forough , Mirzababaei Atieh , Abdollahi Afsoun , Shiraseb Farideh , Mirzaei Khadijeh
Published: August 2020

Background: The double burden of malnutrition is an emerging public health concern nowadays which a correlation with Obesity. The aim of this study was to examine the relationship between resting metabolic rate (RMR) and dietary intake of zinc, vitamin C, and riboflavin based on Nutrient Adequacy Ratios (NAR) in overweight and obese women.Methods: We enrolled 293 overweight and obese women in this cross-sectional study. BMI, body fat mass, fat-free mass, insulin level were assessed. RMR was measured using indirect calorimetry. NAR was measured by calculating the ratio of daily individual intakes to the standard recommended amounts.Results: the RMR/FFM showed a significant association with riboflavin (β=1.59; 95% CI: 1.04-23.26, P=0.04) and zinc (β=0.78; 95% CI: 1.04-4.61, P=0.03) in the crude model. Moreover, differences in vitamin C and RMR/FFM was marginal significant (β=0.75; 95% CI: 0.95-4.77, P=0.06). After adjust for confounders the riboflavin association change to marginal significance (β=1.52; 95% CI: 0.91-23.04, P=0.06). After controlling for potential confounders, the associations change between zinc and RMR/FFM (β=0.66; 95% CI: 0.78-4.86, P=0.15) and between RMR/FFM and vitamin C (β=0.48; 95% CI: 0.66-3.96, P=0.28).Conclusion: Our study showed a significant association between dietary intake of zinc, riboflavin, and vitamin C and change in RMR/FFM in overweight and obese women.
Association of Body Mass Index and Waist Circumference with Hypertension in Older Adults
Authors: Zhang Wenli , He Kun , Zhao Hao , Hu Xueqi , Yin Chunyu , Zhao Xiaoyan , Shi Songhe
Published: August 2020

Background: The relationship between obesity and prevalent hypertension in older adults has predominantly been estimated using categorical measures of body mass index (BMI) and waist circumference (WC), masking the shape of the dose-response relationship. We aimed to examine the precise relationship of BMI, WC with hypertension, and to assess the appropriate level of BMI and WC for hypertension. Methods: We examined data for 126,123 individuals in Xinzheng city aged ≥60 years from a population based study from January to December 2019. Logistic regression and restricted cubic spline models were applied to assess the relationship and the appropriate level of BMI and WC for hypertension. An additive interaction analysis was used to test synergistic effects between a higher BMI and WC for hypertension. Results: The full-adjusted odds ratios (ORs) with 95% confidence intervals (CIs) of an increase of 1 kg/m2 in BMI and 1 cm in WC for hypertension were 1.084 (1.080-1.087) and 1.025 (1.024-1.027), respectively. Multivariable adjusted restricted cubic spline analyses showed the nonlinear relationships of BMI and WC with hypertension in both men and women (all P<0.001). The risk of hypertension increased steeply with increasing BMI from ≥25 kg/m2 and WC ≥ 88 cm or 86 cm for males and females, respectively. And we observed a significant additive interaction between a higher BMI and WC such that the prevalence of hypertension was significantly enhanced. Conclusion: These findings suggest increased hypertension prevalence in the elderly population with increased BMI and WC. BMI ≤ 25 kg/m2 and WC ≤ 88 cm or 86 cm for males and females may be the best suggestion with regard to primary prevention of hypertension in older adults.
Association between physical function and onset of coronary heart disease in a cohort of community-dwelling older populations: The Septuagenarians, Octogenarians, Nonagenarians Investigation with Centenarians study
Authors: Klinpudtan Nonglak , Kabayama Mai , Godai Kayo , Gondo Yasuyuki , Masui Yukie , Akagi Yuya , Srithum Werayuth , Kiyoshige Eri , Sugimoto Ken , Akasaka Hiroshi , Takami Yoichi , Takeya Yasushi , Yamamoto Koichi , Ikebe Kazunori , Yasumoto Saori , Ogawa Madoka , Inagaki Hiroki , Ishizaki Tatsuro , Arai Yasumichi , Rakugi Hiromi , Kamide Kei
Published: August 2020

Objective: Physical function is a strong predictor of the adverse outcomes in older populations. We prospectively examined the association of walking speed and handgrip strength with CHD in the community-dwelling older populations. The study cohort in Japan included 1272 older people free from heart disease at the baseline. Physical function was identified based on walking speed and handgrip strength assessment at the survey site. Any new case of CHD was obtained based on a self-reported doctor's diagnosis. Cox-proportion hazard models were adjusted for covariate factors to examine the CHD risk. Results: During the 7-year follow-up, 45 new cases of CHD were documented. Slow walking speed was strongly associated with CHD risk after adjusting for all confounding factors in the total participants and women (hazard ratio (HR)= 2.53, 95%confidence interval (CI), 1.20-5.33, p=0.015, and HR= 4.78, 95% CI,1.07-21.35, p=0.040, respectively), but not in men. Weak grip strength was associated with CHD after age-adjustment (HR= 2.45, 95%CI, 1.03-5.81, p=0.043) only in men. However, after additional multivariate adjustment, the associations were weaker. The results lead to the conclusion that, after multivariate adjustment for coronary heart disease, walking speed is a strong surrogate predictor of the CHD risk among older people.
SHED-Derived Exosomes Regulate Microglial Polarization in the Treatment of Traumatic Brain Injury in Rats via miR-330-5p
Authors: Li Ye , Wang Xinxin , Cao Xiaoyu , Li Na , Meng Sun , Li Ang
Published: August 2020

Background: Traumatic brain injury (TBI) causes structural damage and impairs motor and cognitive function of the brain. Our previous study suggested that exosomes (EXs) secreted by stem cells from human exfoliated deciduous teeth (SHED) extenuated motor damage in TBI rats by regulating microglia. The molecular mechanism of SHED-EXs was investigated in the present study. Methods: The miRNA array was performed to determine the differential miRNA expression in SHED-EXs treating microglia. The key miRNA was selected. Flow cytometry, immunofluorescence, enzyme linked immunosorbent assay (ELISA) and Griess assay were performed to detect the function of key miRNA. Real-time PCR, Western blotting and dual luciferase reporter assay were used to confirm the relationship between key miRNA and the target gene. Chromatin immunoprecipitation (ChIP) was performed to determine the downstream pathway of EXs-miRNA. Traumatic brain injury rat model was established and local injection of EXs-miRNA was performed to evaluate the effect.Results: SHED-EXs delivery of miR-330-5p was the key in the regulation of microglia polarization by inhibiting M1 polarization and promoting M2 polarization. Mechanistically, miR-330-5p had an inhibitory effect on Ehmt2, and miR-330-5p/Ehmt2 promoted the transcription of CXCL14 through H3K9me2. In vivo data showed that SHED-EXs/miR-330-5p reduced neuro-inflammation and repaired neurological function of TBI rats. Conclusions: SHED-EXs/miR-330-5p improved the motor function of rats after TBI by inhibiting M1 polarization and promoting M2 polarization of microglia through Ehmt2/H3K9me2/CXCL14 pathway.
Inferences From Dysregulated Long Non-Coding RNA-Mediated Competing Endogenous RNAs in Various Chemotherapy Drugs and Evaluation of Drug Response in Breast Cancer
Authors: Zhang Ziwen , Li Dongbo , Zhang Han , Qin Qi , Zhang Qingyuan
Published: August 2020

Backgroud: Differences in individual drug response, especially drug resistance, present an obstacle to the treatment of breast cancer (BRCA). Thus, the ability to predict drug response would contribute to developing novel treatment strategies. Accumulating evidence have suggested that tumor molecular profiles and drug response data provide opportunities and challenges for the discovery of new molecular characteristics and mechanisms of drug response in BRCA. Methods: In the present study, an integrated pipeline was developed to explore drug response-related long non-coding RNA (lncRNA)-mediated competing endogenous RNAs (ceRNAs) motifs in BRCA. Results: Drug response-specific ceRNAs indicated that lncRNAs play an essential role in various drug treatments for BRCA. Several key drug-resistant and -sensitive dysregulated ceRNAs were identified in Adriamycin, Cytoxan, and Tamoxifen. The interactions in these ceRNAs showed strong correlations in BRCA. Most drug response-related dysregulated ceRNAs were only present in one kind of drug. A number of drug response-related ceRNAs presented diverse dysregulation patterns. We also extracted some key drug response-related lncRNAs, such as HCP5 and FAM182A. These lncRNAs were associated with certain cancer hallmarks and survival in BRCA. Conclusions: Ultimately, understanding the underlying lncRNA-mediated ceRNAs in drug responses will facilitate improved individual reactions to chemotherapy and overall outcomes of BRCA treatment.
ZNF674-AS1 Suppresses Non-Small Cell Lung Cancer Growth Through the miR-423-3p/p21 Axis
Authors: Liu Yu , Huang Risheng , Xie Deyao , Lin Xiaoming , Zheng Liangcheng
Published: August 2020

Background: ZNF674-AS1, a recently characterized long noncoding RNA, shows prognostic significance in hepatocellualar carcinoma and glioma. However, the expression and function of ZNF674-AS1 in non-small cell lung cancer (NSCLC) is unclear. Methods: In this work, we investigated the expression of ZNF674-AS1 in 83 pairs of NSCLC specimens and adjacent noncancerous lung tissues. The clinical significance of ZNF674-AS1 in NSCLC was analyzed. The role of ZNF674-AS1 in NSCLC growth and cell cycle progression was explored. Results: Our data show that ZNF674-AS1 expression is decreased in NSCLC compared to normal tissues. ZNF674-AS1 downregulation is significantly correlated with advanced TNM stage and decreased overall survival of NSCLC patients. Overexpression of ZNF674-AS1 inhibits NSCLC cell proliferation, colony formation, and tumorigenesis, which is accompanied by a G0/G1 cell cycle arrest. Conversely, knockdown of ZNF674-AS1 enhances the proliferation and colony formation of NSCLC cells. Biochemically, ZNF674-AS1 overexpression increases the expression of p21 through downregulation of miR-423-3p. Knockdown of p21 or overexpression of miR-423-3p blocks ZNF674-AS1-mediated growth suppression and G0/G1 cell cycle arrest. In addition, ZNF674-AS1 expression is negatively correlated with miR-423-3p in NSCLC specimens. Conclusions: ZNF674-AS1 suppresses NSCLC growth by downregulating miR-423-3p and inducing p21. This work suggests the therapeutic potential of ZNF674-AS1 in the treatment of NSCLC.
CD4/CD8 ratio can predict the risk of septicemia in HIV infection
Authors: ZHU YINGCHUN , Zheng Ping , Cai Lin , Zhou Ruifeng , Wang Yin , Wang Zongzheng
Published: August 2020

Objectives

There are few reports about the effect of CD4/CD8 ratio on the infection of HIV with sepsis. Here we analyze the correlation between the baseline CD4 / CD8 ratio and the pathogenic spectrum of AIDS patients with sepsis and the effect on the prognosis.

Methods

A retrospective analysis study(May 2010 to June 2017) was carried out using routinely colleted data from HIV with spesis at Chengdu Public Health Clinical Center. The values of clinical data, CD4/CD8 ratio and pathogenic spectrum were evaluated in the study.

Results

Among 322 positive blood culture HIV patients with septicemia, 208 (64.60%) were fungal infection, 64 (19.90%) were gram-negative bacterial infection, 47 (14.60%) were Gram-positive bacterial infection, and 3 (0.90%) were fungal and bacterial infection. Among the fungal infections, Cryptococcus was found in 152 cases (73.08%), followed by cyanobacteria marneffei in 53 cases (25.48%) and Candida in 3 cases (1.44%); Salmonella in 38 cases (59.38%) and Escherichia coli in 17 cases (26.56%); Staphylococcus in 28 cases (59.58%) were positive. When the CD4 / CD8 ratio≤0.3, the risk of sepsis infection was significantly higher than that of CD4 / CD8 > 0.3. The lower the ratio of CD4 / CD8 (< 0.1), the higher the risk (χ 2 =188.968,P = 0.00).When the ratio of CD4 / CD8 was less than or equal to 0.3, the incidence of fungal infection was significantly increased (67.14%), and the incidence of gram-negative bacterial infection (18.02%) was significantly higher than that of Gram-positive bacterial infection (13.78%), (χ 2 = 283.277, P = 0.00); when the ratio of CD4 / CD8 was greater than or equal to 0.3, the incidence of septicemia was significantly reduced, and there was no significant difference between the original spectrum of infection (χ 2 = 1.750, P=0.42)。 286 patients (88.82%) were discharged after treatment, 36 patients (11.18%) died after treatment.

Conclusions

In Chengdu of China, the main pathogens of septicemia in AIDS patients are fungi, including Cryptococcus and cyanobacteria marneffei, next are bacteria containing Salmonella and Staphylococcus. The lower the ratio of CD4 / CD8, the higher the risk of infection with sepsis, the higher the risk of multiple infection, and the higher the mortality. Therefore, we think that CD4 / CD8 ratio is an important risk factor for HIV infection with septicemia. We should pay more attention to role of the CD4 / CD8 ratio in clinical work, and it may be help us predicting progress of HIV disease.
Relevance of Regional Lymph Node Invasion in Radical Hepatectomy and Lymphadenectomy for Alveolar Echinococcosis: A Retrospective Cohort Study
Authors: Yang Xianwei , Wang Tao , Shen Shu , Wang Wentao
Published: August 2020

Background Hepatic Alveolar echinococcosis (AE) is also known as worm cancer, parasitic cancer, and it often invades the regional lymph nodes of the liver. The present study was to investigate the clinical value of radical hepatectomy and lymphadenectomy in AE patients. Methods Our study enrolled consecutive AE patients who underwent radical hepatectomy with removal the regional lymph nodes between January 2009 and April 2019. Patients with inflammatory lymph node enlargement was included in group A, and patients with AE lymph node invasion were included in group B. The clinical characteristics, survival and recurrence rates were compared.Results A total of 103 patients were enrolled group A, and 24 in group B. Preoperative computed tomography showed that the lymph node positivity rate in group B was 70.8% while that in group A was 43.7% (p=0.017). The lymph node diameter was 1.8±0.9 cm in group A vs 2.5±1.1 cm in group B (p=0.004), and the lymph node number (p=0.035) and lymph node location (p=0.001). A total of 10 patients (7.9%) had recurrent lesions, and 6 patients (4.7%) died (P>0.05). Conclusions lymph node diameter, number, and distance from the liver were important characteristics for describing lymph node invasion. There was no difference in the long-term efficacy of lymphadenectomy between patients with lymph node enlargement and those with invasion.
Lecture notes on Generalised Hydrodynamics
Authors: Doyon Benjamin
Published: August 2020

These are lecture notes for a series of lectures given at the Les Houches Summer School on Integrability in Atomic and Condensed Matter Physics, 30 July to 24 August 2018. The same series of lectures has also been given at the Tokyo Institute of Technology, October 2019. I overview in a pedagogical fashion the main aspects of the theory of generalised hydrodynamics, a hydrodynamic theory for quantum and classical many-body integrable systems. Only very basic knowledge of hydrodynamics and integrable systems is assumed.
El dictamen pericial odorológico: Breve análisis de su efectividad en la provincia de Guantánamo
Authors: Fuentes Estévez Jorge Aquiles , Naranjo Gómez Vladimir , González Sosa Guido Fabián
Published: August 2020

La presente investigación pretende fundamentar desde una perspectiva histórica, doctrinal, legal el estudio de la odorología criminalística como técnica, a partir de su análisis jurisprudencial en la academia patria, referido a su aplicación y evaluación del dictamen pericial odorológico como medio de prueba en el proceso penal cubano, partiendo de la experiencia de su empleo en la provincia de Guantánamo. Para el logro de los resultados obtenidos se utilizaron los siguientes métodos generales de las ciencias: análisis síntesis, inducción-deducción, teórico jurídico, jurídico comparativo y exegético, así como las técnicas de investigación, la entrevista, el análisis de documentos, el análisis secundario, el estudio de casos y el análisis estadístico.
Acceso al agua y desarrollo sostenible: la protección de recursos hídricos estratégicos para su aprovechamiento por las generaciones futuras
Authors: Pedreira María Sol
Published: August 2020

El presente artículo pretende ilustrar, analizar y reflexionar sobre diferentes acciones que pueden ser observadas dentro de un Estado, en este caso ocurridas en la República Argentina, en orden a alcanzar el objetivo n° 6 de los Objetivos para el desarrollo sostenible -ODS-, es decir, “Garantizar la disponibilidad y la gestión sostenible del agua y el saneamiento para todos”, el cual es integrante del Programa Interamericano para el Desarrollo Sostenible (PIDS), para el período 2016-2021, aprobado según AG/RES 2882 (XLVI-O/16) del 14/06/16 de la Asamblea General de la Organización de los Estados Americanos. Si bien todas las metas incluidas dentro del ODS n° 6 son prioritarias en dicho programa y sin dejar de resaltar la vinculación existente entre ellas y con las emergentes de los restantes ODS, con el presente trabajo se busca profundizar sobre la meta n° 6.4, la cual persigue, entre otras cosas, asegurar la sostenibilidad de la extracción de agua.
Factores personales y psicológicos que influyen en la Intención Emprendedora en estudiantes de la Universidad de Panamá
Authors: Alvites Huamaní Cleofé Genoveva , López Sinisterra Omar , Berra Ruiz Enrique , Muñoz Maldonado Sandra Ivonne
Published: August 2020

El objetivo del presente estudio fue analizar la relación explicativa de la intención emprendedora, mediante el análisis de las múltiples relaciones entre autoeficacia para el emprendimiento, el ámbito personal, formación para la creación de empresa, actitud para emprendimiento, motivación para la creación de empresa, apoyo financiero como factores personales de los estudiantes de pregrado de la Universidad de Panamá. Se aplicaron dos cuestionarios, en una muestra se realizó 474 estudiantes, entre 16 y 60 años, del sexo femenino en mayor porcentaje, pertenecientes a las diferentes escuelas académicas. Realizándose el análisis bajo el modelo de ecuaciones estructurales para explicar las relaciones entre las variables de interés, para ello se identificaron cinco modelos, siendo el último modelo referido a la motivación, que resultó ser la variable que mejor predice y explica la intención emprendedora. Se discute el rol de la motivación en la intención emprendedora en contraposición a la actitud emprendedora que reporta la literatura.
Gestão da inovação:
Authors: Vita Cláudio Aguiar , Góes Helbert José de , Pereira Valéria Antÿnio , Moura Luiz Rodrigo Cunha , Birchal Rahimá Aparecida Mendonça da Costa
Published: August 2020

Não somente a inovação por si só, mas o processo de inovação é um dos temas que despertam o interesse de pesquisadores das áreas de gestão. Além disso, a sua importância em relação às implicações gerenciais torna o tema ainda mais premente. O objetivo deste trabalho foi analisar a gestão de uma pequena empresa do setor de logística, com sede em Belo Horizonte – MG. A metodologia utilizada teve abordagem qualitativa, sendo caracterizada por uma pesquisa exploratória realizada por meio de entrevista e análise de documentos. Os resultados foram obtidos por meio da técnica de análise de conteúdo e indicam que a empresa estudada realiza várias ações do processo de gestão da inovação tais como: procura, seleção e inovação, apresentando várias habilidades preconizadas pela teoria da gestão da inovação. Além disso, ela também apresenta as vantagens das pequenas empresas na gestão da inovação, tais como facilidade na comunicação entre os seus membros, flexibilidade e capacidade de adaptação, além da rapidez no processo decisório.
Informação incompleta ou imperfeita:
Authors: Araújo Jamille Carla Oliveira , Carlos Cruz Lady Dayane
Published: August 2020

Este artigo tem como objetivo identificar a importância da classificação das informações contábeis incompletas e imperfeitas para escritórios contábeis. Dado o panorama de estudo, trabalhou-se com uma abordagem qualitativa e quantitativa, de caráter descritivo, como forma de mensurar a produção da informação contábil nos escritórios estudados e seu reflexo quando ela é feita de modo incompleto ou imperfeito. Dentre os resultados de estudo, observou-se que os escritórios estão acompanhando o crescimento dessas empresas, fornecendo serviços gerenciais que propiciem dados relevantes para empresas, entretanto, estas, culturalmente, ainda mantêm uma relação das empresas com os escritórios como controladores de obrigações fiscais. O estudo torna-se relevante por utilizar uma abordagem sobre a qualidade dos demonstrativos contábeis publicados e arquivados na Junta Comercial (arquivo público) de micro e pequenas empresas por profissionais de contabilidade, tendo um quantitativo considerável de empresas avaliadas e ainda não terem sido utilizadas em estudo brasileiros.
Análise de sustentabilidade financeira no segmento imobiliário na região nordeste de Belo Horizonte
Authors: Filho Danilo Eustáquio Oliveira
Published: August 2020

Este artigo tem como objetivo identificar quais as variáveis que influenciam na sustentabilidade dos negócios empresariais na percepção dos gestores. A sustentabilidade hoje nas empresas é uma ferramenta importante para seu crescimento e sobrevivência no longo prazo. Este estudo analisou como os gestores das imobiliárias trabalham com a sustentabilidade financeira e quais os seus resultados. Utilizou-se, primeiramente, a pesquisa bibliográfica, seguida por uma pesquisa quantitativa onde foi aplicado um questionário as imobiliárias dos bairros Dona Clara e Liberdade na cidade Belo Horizonte/MG. Esta pesquisa mostrou a importância das variáveis de sustentabilidade financeira com: planejamento financeiro, capital de giro e fluxo de caixa e como os gestores utilizam essas variáveis para que seu negócio seja sustentável financeiramente. O resultado desta pesquisa identificou que os gestores têm conhecimento sobre as variáveis que influenciam a sustentabilidade, mas mostrou também paradoxos na utilização destas variáveis.
Estudo de caso da gestão de estoque de uma clínica de estética
Authors: Santos de Arruda Antonio Carlos , Arruda Patrícia Santos de , Martins Andressa da Silva , Almeida Fernanda Cruz de
Published: August 2020

Este artigo apresenta um estudo de caso sobre a gestão de estoque de uma clínica de estética, no qual há uma má administração de reposição, afetando diretamente o cliente. Contudo, foi formulado um instrumento de pesquisa para o responsável da atividade de estoque na empresa, conforme o referencial teórico consultado, para obter informações que estejam causando essa falha na gestão. Entretanto, após a validação das respostas, é notável que existe uma falta de conhecimento sobre o processo de gerenciamento de estoque e importância nessa área. Foram apresentadas técnicas de administração para a resolução desse problema, e, também, melhorias na visualização de como isso é possível afetar a imagem da empresa.
Dose-effect of an asthma self-management program for adolescents: a short report (Preprint)
Authors: Wu Chiung-Jung (Jo) , Chang Anne M.
Published: August 2020

UNSTRUCTURED

Multiple delivery modes of asthma self-management programs enable adolescents to manage asthma efficiently but have different levels of impacts on health outcomes. Secondary data analysis was used to determine differences in outcomes of asthma self-efficacy, prevention behaviors, asthma medication adherence, and asthma symptoms among the intervention doses. The findings showed participants who completed all intervention components (high dose) had significant greater self-efficacy, prevention behaviors and medication adherence, but no improvements on the asthmatic symptoms. The clinical implementations should take the intervention dose-effect into account and make necessary refinements when care for adolescents with asthma.

INTERNATIONAL REGISTERED REPORT

RR2-doi.org/10.1016/j.conctc.2017.09.005
Prescribing Phones to Address Health Equity Needs in the COVID-19 Era: The PHONE-CONNECT Program (Preprint)
Authors: Kazevman Gill , Mercado Marck , Hulme Jennifer , Somers Andrea
Published: August 2020

UNSTRUCTURED

Vulnerable populations have been identified as having higher infection rates and poorer COVID-19–related outcomes, likely due to their inability to readily access primary care, follow public health directives, and adhere to self-isolation guidelines. As a response to the COVID-19 pandemic, many health care services have adopted new digital solutions, which rely on phone and internet connectivity. However, persons who are digitally inaccessible, such as those experiencing poverty or homelessness, are often unable to use these services. In response to this newly highlighted social disparity known as “digital health inequity,” emergency physicians at the University Health Network in Toronto, Canada, initiated a program called PHONE-CONNECT (Phones for Healthier Ontarians iN EDs – COvid NEeds met by Cellular Telephone). This novel approach attempts to improve patients’ access to health care, information, and social services, as well as improve their ability to adhere to public health directives (social isolation and contact tracing). Although similar programs addressing the same emerging issues have been recently described in the media, this is the first time phones have been provided as a health care intervention in an emergency department. This innovative emergency department point-of-care intervention may have a significant impact on improving health outcomes for vulnerable people during the COVID-19 pandemic and beyond.
Appeal of Editor-in-Chief
Authors: Pankiv V.I.
Published: August 2020

No abstract
Soy phytoestrogens: hormonal activity and impact on the reproductive system
Authors: Jargin S.V.
Published: August 2020

Phytoestrogens (PhE) are contained in soy and some other plants; they are structurally similar to estrogens. PhE are used for substitution therapy in the menopause. However, some recent reviews concluded that no satisfactory evidence has been provided in favor of PhE efficiency against menopausal symptoms compared to placebo. Soy is used as an ingredient of infant food and other foodstuff as well as cattle fodder, so that residual PhE and their degradation products, e.g. equol, having estrogenic activity, can remain in meats. Soy protein is used in the food industry. Disorders of the reproductive system in humans under the influence of PhE are regarded to be rare and mild. There were single reports on altered gender-related behavior in children and feminization associated with soy consumption. In animals, the excessive PhE intake leads to derangements of fertility, sexual development and behavior. PhE are called modulators or disruptors of the endocrine system. There are no reasons to assume that benefits from such modulation would prevail in all soy consumers. Feminizing effects may be inconspicuous but statistically detectable in large populations.
Тернопольский национальный медицинский университет имени И.Я. Горбачевского Министерства здравоохранения Украины, г. Тернополь, Украина
Authors: Kovalchuk T.A. , Boyarchuk O.R.
Published: August 2020

Актуальность. Результаты последних научных исследований позволяют предположить, что витамин D может оказывать косвенное, а в некоторых случаях и прямое действие в патогенезе вазовагальных синкопе у детей. Цель исследования: изучить уровни витамина D в сыворотке крови детей с вазовагальными синкопе. Материалы и методы. Основную группу составили 30 детей в возрасте 8–17 лет с как минимум одним эпизодом вазовагального синкопе в течение последнего месяца. В контрольную группу вошли 24 практически здоровых ребенка. 25(ОН)D в сыворотке крови определяли методом иммуноферментного анализа с использованием тест-системы Monobind (США). Оценку витамин-D-статуса осуществляли в соответствии с практическими рекомендациями по добавкам витамина D и лечению дефицита в Центральной Европе: дефицит — < 20 нг/мл; субоптимальный уровень (недостаточность) — 20–30 нг/мл; оптимальный уровень — 30–50 нг/мл; высокое содержание — 50–100 нг/мл; опасный уровень — > 100 нг/мл. Результаты. Дети обеих групп были сопоставимы по результатам демографических и клинических показателей, что позволило нивелировать влияние пола, возраста, дефицита и избыточной массы тела, ожирения или артериальной гипертензии на уровень 25(ОН)D. Показатель 25(ОН)D в группе вазовагальных синкопе составил 19,17 ± 1,33 нг/мл и был достоверно ниже по сравнению со здоровыми детьми — 30,91 ± 1,20 нг/мл (р = 0,000001). Оптимальный уровень витамина D регистрировали только у 6,7 % больных с вазовагальными синкопе, тогда как дефицит и недостаточность витамина D — у 33,3 и 60,0 %. Показатели кальция, фосфора и щелочной фосфатазы в сыворотке крови обследованных обеих групп не отличались (p > 0,05). Выводы. У 93,3 % детей с вазовагальными синкопе наблюдается достоверное снижение уровня 25(OH)D в сыворотке крови. Распространенность дефицита витамина D составляет 60,0 %, субоптимального уровня 25(ОН)D — 33,3 %. Дефицит и недостаточность витамина D ассоциируются с сохранением традиционных показателей кальций-фосфорного гомеостаза в пределах референтных значений.
Тиреотоксический криз: современные представления, подходы к диагностике и лечению
Authors: Makar R.D. , Pavlovskyi I.M. , Makar O.R.
Published: August 2020

Обзор посвящен одному из тяжелейших критических состояний в практике эндокринолога — тиреотоксическому кризу (ТК). Приведены современные представления об этиологии и патогенезе этого осложнения, проанализированы особенности клинического течения. ТК — это угрожающее жизни состояние, которое может развиться у больного с некомпенсированным тиреотоксикозом, характеризуется резким обострением его клинических проявлений и прогрессирующими расстройствами гомеостаза; при отсутствии адекватного лечения, как правило, заканчивается летально. Следует взять за правило: в случае внезапного ухудшения состояния пациента с тиреотоксикозом всегда необходимо помнить о возможности развития ТК, при этом на первый план могут выступать симптомы болезни, которая его спровоцировала. Большинство специалистов считает, что в сомнительных случаях лучше ошибиться в предположении о наличии ТК в данный момент или угрозе его развития и все-таки начать интенсивную терапию, чем упустить диагноз. Благодаря созданию и внедрению в широкую клиническую практику антитиреоидных лекарственных средств, β-адреноблокаторов, нейролептиков и других лечебных мероприятий летальность при ТК кардинально снизилась и составляет около 10 %. Достоверными предикторами пессимистического прогноза служат прогрессирующие гипертермия, тахиаритмия и нарушения деятельности ЦНС, а также присоединение желтухи. Смерть может наступить вследствие сердечной и/или дыхательной недостаточности, шока, полиорганной недостаточности, гипертермии, диссеминированной внутрисосудистой коагуляции, сепсиса или других осложнений. В конце концов, если пациенты выживают, у части из них наблюдаются необратимые расстройства, например постгипоксическая энцефалопатия, цереброваскулярная патология, атрофия мышц, психозы или почечная недостаточность. С учетом официальных международных рекомендаций рассмотрены принципы диагностики, лечения и профилактики данного критического состояния. Мировой опыт показывает, что неотложная мультимодальная терапия тиреотоксического криза способна снизить летальность до 10–20 %.
Нарушения репродуктивной функции и гормонального профиля у пациенток с АКТГ-секретирующими аденомами гипофиза
Authors: Halimova Z.Yu. , Irgasheva O.B.
Published: August 2020

Актуальность. Синдром Кушинга (СК) — тяжелая нейроэндокринная патология, которая уже многие годы находится под пристальным вниманием различных специалистов вследствие разноплановости ее осложнений. Гиперандрогения и нарушения менструального цикла, такие как аменорея и олигоменорея, дополняют клиническую картину СК. Цель исследования: оценить состояние фертильной функции и гормонального профиля у пациенток с синдромом Кушинга. Материалы и методы. Под наблюдением по поводу СК находились в период с 2000 по 2019 г. 163 пациентки фертильного возраста. Средний возраст обследуемых составил 27,58 ± 3,40 года (от 17 до 49 лет), длительность заболевания — 4,2 ± 0,2 года. 20 здоровых женщин соответствующего возраста составили группу контроля. Результаты. Пациентки с СК были распределены следующим образом: первая группа — с АКТГ-зависимым СК — 130 (79,7 %), вторая группа — с АКТГ-независимым СК — 30 (18,4 %) и третья группа — с АКТГ-эктопированным СК — 3 (1,8 %). Среди различных репродуктивных нарушений у пациенток с СК преобладали нарушения менструального цикла и вторичная аменорея. Для пациенток первой группы на 14-й день менструального цикла характерным было достоверное снижение базальных уровней лютеинизирующего и фолликулостимулирующего гормонов, снижение уровня овариальных гормонов (эстрадиол, прогестерон) на фоне гиперандрогенемии и достоверное повышение уровня кортизола крови при увеличении показателя АКТГ. Гиперплазия обоих надпочечников диагностирована у 110 (84,6 %) больных с АКТГ-зависимым СК, узелковая гиперплазия обоих надпочечников — у 13 (10 %), инциденталома — у 3 (2,3 %), узелковая гиперплазия одного надпочечника — у 2 (1,5 %). Выводы. У пациенток с синдромом Кушинга наблюдались репродуктивные расстройства: нарушение менструального цикла — у 32,9 %, вторичная аменорея — у 20,4 %. Большая часть нарушений менструального цикла установлена в группе больных с АКТГ-зависимым синдромом Кушинга. Нарушения менструального цикла проявлялись в виде олигоменореи (30 % случаев), аменореи (35 %), полименореи (7,5 %) и вариабельности цикла (7,5 %).