bluuebunny/crossref_metadata_2025 huggingface dataset:
Roles of C-Peptide and Triglyceride as Effective Indices for Insulin Resistance Investigations in Iraqi Women with Polycystic Ovarian Syndrome
Authors: H. Al-Murshedi Hadbaa , J. Al-Tu’ma Fadhil , A. Hadi Eman , Mustafa Mohammed Borhan , Al-Kayat Tarik
Published: July 2022

Objectives: To assess how much Insulin Resistance (IR) in both obese and non-obese PCOS women used as index of PCOS and find out a correlation between various methods used for evaluation of IR.Methods: A study included 120 participants (68 women have PCOS subdivide according to their BMI to 45 obese (BMI>=30) and 23 non-obese (BMI<30). The remaining 52 participants represent as apparently control group with normal weight and normal menstrual cycle. Patients with PCOS were selected from the Infertility Department, Gynecology and Obstetrics Teaching Hospital in Kerbala, Iraq between Nov., 2021 and June, 2022. Diagnosis of PCOS is based on 2 of 3 findings: oligo/anovulation, hyperandrogenism, polycystic ovaries in ultrasound (Rotterdam criteria). Patients were interviewed and examined for weight, height, waist and hip circumferences. Venous blood samples were collected and insulin resistance was assessed by different methods including homeostatic model assessment of insulin resistance (HOMA-IR), G/I ratio, QUICKI, McAuly, TyG index and C-peptide index.Results: The assessment of IR revealed that HOMA-IR, QUICKI, McAuley, TyG and CPI had significant difference in both PCOS groups compared with controls. G/I ratio was significantly higher in the controls than obese PCOS women. The prevalence of IR based on (HOMA-IR) was 80% in obese PCOS and 48% in non-obese PCOS women. In obese PCOS women HOMA-IR strongly and negatively correlates with G/I ratio (r= -0.81, P<0.001), QUICKI (r= -0.89, P<0.001), McAuley (r= -0.79, P<0.001) and C-peptide (r= -0.56, P<0.001). Whereas it was positively correlates with insulin (r=0.99, P<0.001), C-peptide (r=0.71, P<0.001) and TyG index (r=0.51, P<0.001). In non-obese PCOS women, HOMA-IR strongly and negatively correlates with G/I ratio (r= -0.79, P<0.001), QUICKI (r= -0.93, P<0.001) and McAuley (r= -0.77, P<0.001). Whereas it was positively correlates with insulin (r=0.99, P<0.001), C-peptide (r=0.49, P<0.05) and TyG index (r=0.47, P<0.05).Conclusion: The observed results concluded that TyG is a valuable indicator to predict IR in obese women with PCOS, partly due to its analytical and financial ease-of-access in all clinical laboratories. The use of TyG index is recommended in the assessment of IR risk among Iraqi women with PCOS.
Concept analysis of professionalism in teachers and faculty members
Authors: Shokri Taiebe , Yazdani Shahram , Ahmadi Soleiman , Afshar Leila
Published: July 2022

Objectives: Considering the important role of medical education teachers to prepare teachers and students in the future, the need to determine the concept of professional teacher and teacher and the characteristics of teacher professionalism, we have explained the concept of professionalism in teachers in this study.

Methods: The concept analysis method used in this research was Walker and Avant method which has eight steps. Walker and Avant state the purpose of concept analysis as follows: The process of distinguishing between the defining features of a concept and its unrelated features. The process of concept analysis includes selecting a concept, determining the purpose of the analysis, identifying the uses of the concept, determining the defining features of the concept, identifying a model, identifying boundary and adversarial items, identifying the precedents and consequences of the concept, and defining empirical references. Is

Results: Professionalism in its general sense, requires deep knowledge, insight, creating a healthy and safe environment, honesty and trust, impartiality, commitment to the profession and continuous improvement, punctuality, criticism, professional competence, responsibility and individual accountability, especially In social interactions, there is an effort for continuous improvement that the acquisition of these characteristics is not easily possible and requires education, especially continuous learning. Professionalism is a set of values, behaviors and relationships that underpin public trust in teachers.

Conclusion: The most important application of this analysis is the concept of basing the definition provided in order to objectively and realistically evaluate the professionalism of professors and strive to improve and enhance it.
Evaluation of DNA Damage in Traffic Cops Exposed to Polycyclic Aromatic Hydrocarbon Pollution in Baghdad City Streets and its Association to Certain Biomarkers
Authors: R. Salem Ashraf , A.R. Al-Wasiti Estabraq , A. Hasan Fahem
Published: July 2022

Objectives: To find out the extent to which the genetic material of Baghdad traffic policemen is affected by the oxidative damage caused by pollutants by monitoring the levels of 8-OHdG compared to the levels of antioxidant enzymes and malondialdehyde.

Methods: This study includes 140 participants; they have been divided into two groups (traffic police and office police). Polycyclic aromatic hydrocarbons were analyzed for each participant by GC/FID while 8-OHdG and antioxidant enzymes were measured by the ELISA technique.

Results: The levels of polycyclic aromatic hydrocarbons, 8-Oxo-dG, and malondialdehyde were elevated in the blood of the traffic police compared to the office police, while higher levels of antioxidant enzymes (Catalase and glutathione peroxidase) were observed in the blood of the office police. 

Conclusion: Exposure to polycyclic aromatic hydrocarbones can cause oxidative stress through their metabolic derivatives and the resulting active molecules, which lead to the formation of 8-Oxo-dG and the reduction of enzymatic antioxidants, which may lead to the emergence of cancers.
Association between Variant Alleles of the X-Ray Cross Complementing Gene (XRCC1) with Benzo[a]Pyrene Levels in Iraqi Workers
Authors: R. Omrain Alaa , A.R. Al-Wasiti Estabraq , Jassim Hamzah Mohammed
Published: July 2022

Objectives: Assessment of a single nucleotide polymorphism of the XRCC1 (codon Arg399Gln) gene and its association with levels of benzo[a]pyrene in blood of car repairers and control group.

Methods: The current study included (111) participants, (37) of the iraqi car repairers, (37) sellers of spare part, and (37) healthy (controll), with the same age range. benzo[a]pyrene was determined by using HPLC technique. Alleles frequency of singl nucleotide polymorphisms of XRCC1 gene was determined by Restriction fragment length polymorphisms (PCR-RFLP).

Results: The results of current study indicated that there is a highly significant increase of B[a]P level (p= 0.0001) in the repairers group compared to the groups of spare part sellers and control together. The genotype frequencies studies of XRCC1 gene of car repairers group and controls. The effect of rs25487 genotypes on exposure to PAHs include higher levels of PAHs and PAH-DNA adduct in TT genotype followed by CT genotype and CC showed lower levels.

Conclusions: As results of prolonged exposure to the higher levels of PAHs that Iraqi car repaiers suffer from, they have highe levels B[a]P. especially those who have the TT genotypes, as results of the inefficiency of thier DNA repair system. Compared to the other genotypes.
Pengaruh pemasaran konten terhadap minat beli tamu di sthala, a tribute portfolio hotel, ubud bali by marriott international
Authors: Rastitiati Ni kade Juli , Wira Darma Dewa Gede , Sudiksa I Nyoman
Published: July 2022

Tujuan dari penelitian ini adalah untuk menganalisis pengaruh firm generated content terhadap minat beli tamu, pengaruh electronic word of mouth terhadap minat beli tamu, serta pengaruh firm generated content dan electronic word of mouth secara simultan terhadap minat beli tamu di Sthala, a Tribute Portfolio Hotel, Ubud Bali by Marriott International. Teknik pengumpulan data dalam penelitian ini adalah melalui kuesioner yang disebarkan kepada pengikut di media sosial instagram Sthala Ubud Bali, dengan hasil 100 kuesioner dikembalikan dan layak untuk dianalisis. Teknik analisis data yang digunakan dalam penelitian ini adalah uji asumsi klasik, analisis regresi linier berganda, uji t, uji F, koefisien determinasi, dan sumbangan efektif dengan bantuan program SPSS for windows version 25. Hasil dari penelitian ini menunjukkan bahwa firm generated content secara parsial berpengaruh positif dan signifikan terhadap minat beli tamu, electronic word of mouth secara parsial berpengaruh positif dan signifikan terhadap minat beli tamu, serta firm generated content dan electronic word of mouth secara simultan berpengaruh positif dan signifikan terhadap minat beli tamu di Sthala, a Tribute Portfolio Hotel, Ubud Bali by Marriott International. Firm generated content dan electronic word of mouth memberikan pengaruh sebesar 54,1% terhadap minat beli tamu, sedangkan sisanya sebesar 45,9% disebabkan oleh variabel lain yang tidak disebutkan dalam penelitian ini.
Desain fasilitas wisata gonda berkonsep ekowisata di grembengan, bongan
Authors: Pramesti Dinar Sukma , Arismayanti Ni Ketut , Dewi I Gusti Ayu Melistyari
Published: July 2022

Bongan memiliki sumber daya alam yang melimpah yaitu gonda yang dapat dijadikan produk oleh-oleh. Saat ini tren wisata yang berkembang adalah wisatawan tidak hanya bisa membeli dan menikmati kuliner atau produk lokal tetapi juga turut serta dalam belajar mengolah dan membuat produk. Tujuan penelitian ini yaitu menganalisis potensi fasilitas wisata gonda di Grembengan dan mendesain fasilitas wisata gonda berkonsep ekowisata di Grembengan. Keberadaan sumber daya alam yang melimpah dan berada di alam, menjadikan tema ekowisata tepat diterapkan dalam perencanaan fasilitas wisata ini. Metode penelitian yang digunakan yaitu metode desktiptif kualitatif dengan analisis SWOT, selanjutnya strategi yang didapat dianalisis ke dalam gambar perencanaan. Hasil penelitian menunjukan bahwa dilihat dari aspek internal kekuatan yang dimiliki yaitu pada kawasan terdapat sawah dan produksi gonda yang melimpah, namun ada kelemahan yaitu daerah sekitar juga merupakan penghasil gonda. Peluang yang ada yaitu Grembengen memiliki lahan luas dan telah memiliki fasilitas pendukung dan atraksi air terjun. Ancaman yang ada yaitu alih fungsi lahan dan ketidakselarasan fasilitas yang dikembangkan dengan lingkungan dan budaya sekitar. Berdasarkan analisis potensi, didapat strategi: 1) Merencanakan fasilitas wisata ramah lingkungan dengan memaksimalkan potensi sawah dan air terjun (nilai konservasi), 2) Merencanakan fasilitas wisata yang unik dan berbeda (nilai edukasi dan wisata), 3) Perencanaan fasilitas wisata yang sesuai daya dukung, serta bentuk dan bahan bangunan selaras dengan lingkungan dan budaya setempat (nilai edukasi dan wisata), 4) Merencanakan fasilitas wisata yang mendukung partisipasi dan ekonomi masyarakat sekitar (nilai partisipasi dan ekonomi).
Pembuatan minuman tradisional loloh daun belimbing wuluh sebagai atraksi wisata kuliner alternatif di desa beraban, tabanan – bali
Authors: Widuri Setyowati ayu , Arismayanti Ni Ketut
Published: July 2022

Saat ini perkembangan wisata kuliner di Bali sudah mulai banyak di lirik dan menjadi salah satu tujuan orang berwisata ke Bali. Kuliner tradisional Bali selama ini yang terkenal adalah jenis makanan sedangkan untuk minuman belum begitu di ketahui oleh wisatawan padahal minuman tradisional Bali sangat banyak jenis dan ragamnya. Salah satu minuman tradisional Bali adalah Loloh.

Loloh adalah ramuan herbal khas Bali yang bermanfaat bagi kesehatan dan juga sebagai minuman segar pelepas dahaga. Salah satu loloh yang memiliki khasiat kesehatan dan juga melepas dahaga adalah loloh daun belimbing wuluh, daerah penghasil loloh daun belimbing wuluh dengan pengolahan tradisional di Bali berada di Kabupaten Tabanan tepatnya di Desa Beraban, Kecamatan Selemadeg Timur, Kabupaten Tabanan.

Metode pengumpulan data dalam penelitian ini adalah dengan melakukan obsevasi, wawancara mendalam dan studi kepustakaan. Sedangkan teknik pengumpulan data yang di gunakan dalam penelitian kualitatif berupa teknik perekaman dengan kamera. Penentuan informan dalam penelitian ini dilakukan secara purposive yaitu informan terpercaya. Informan dalam penelitian ini adalah pembuat loloh belimbing wuluh di Desa Beraban, Kecamatan Selemadeg Timur, Kabupaten Tabanan. Teknik analisis data yang di pakai dalam penelitian ini adalah deskriftif kualitatif

Proses pengolahan loloh daun belimbing wuluh ini bisa di jadikan atraksi kuliner alternative di desa Beraban, Tabanan – Bali dengan keunggulan proses pengolahan yang masih di lakukan secara tradisional dan memiliki rasa yang khas serta bermanfaat untuk tubuh. Loloh daun belimbing wuluh ini bisa di promosikan pada wisatawan yang berkunjung ke desa Beraban Tabanan – Bali sebagai salah satu alternative atraksi wisata kuliner yang akan sangat bermanfaat bagi  perekonomian masyarakat setempat.

Kata kunci : minuman tradisional, loloh, bali
Analisis good corporate governance pada pengadaan bahan makanan di fame hotel sunset road bali
Authors: Sudarsana I Ketut , Dewi Ni Kadek Shinta
Published: July 2022

Kelancaran aktivitas operasional Fame Hotel Sunset Road Bali merupakan hal penting yang dapat mempengaruhi peningkatan kepuasan tamu, oleh karena itu hotel harus memiliki kesanggupan untuk menyediakan segala kebutuhan tamu. Pengadaan bahan makanan memegang peran penting dalam menyediakan bahan dan kebutuhan operasional hotel. Manajemen harus mampu memilih supplier yang dapat bekerjasama dalam memenuhi kebutuhan operasional hotel sesuai dengan standar yang telah ditetapkan oleh hotel. Rumusan masalah dari penelitian ini adalah bagaimanakah penerapan good corporate governance pada pengadaan bahan makanan di Fame Hotel Sunset Road Bali dan dengan tujuan untuk mengetahui penerapan good corporate governance pada pengadaan bahan makanan di Fame Hotel Sunset Road Bali. Teknik analisis data yang digunakan dalam penelitian ini adalah deskriptif kualitatif yang diperoleh dari wawancara, observasi, dan dokumentasi. Penelitian ini ditunjang dengan lima prinsip dari praktik Good Corporate Governance yang diatur dengan Keputusan Menteri BUMN Kep-117/M-MBU/2002 bab II pasal 3 yakni transparansi,  akuntabilitas, pertanggungjawaban, kemandirian, dan kewajaran. Hasil penelitian menunjukkan bahwa penerapan good corporate governance pada pengadaan bahan makanan di Fame Hotel Sunset Road Bali belum berjalan dengan baik. Pembelian bahan makanan belum berdasarkan standard purchase specification. Bagian penerimaan dalam menerima bahan makanan hanya melihat kualitas bahan makanan dari tampilan luar saja. Penataan dan penempatan bahan makanan digudang belum sesuai dengan tata kelola penyimpanan dan metode first in first out saat pengeluaran tidak diterapkan.
Case Report : Lymphocytic Lobulitis With Fibrocystic Disease Of The Breast
Authors: Tannistha Chakraborty  , Dr. Shreya Shetty  , Dr. K.S Ravishankar
Published: July 2022

Lymphocytic lobulitis , is a fibroinflammatory benign condition of the breast which is associated with type 1 diabetes mellitus. This benign condition is uncommon and may be mistaken for inflammatory carcinoma of the breast. We report the case of a 61 year old female patient who presented with a lump in the right breast with a history of Type 2 diabetes mellitus. The lump was associated with discharge and recent onset pain. On examination a vague lump which was non mobile, involving the right breast was palpable. A single firm mobile right axillary lymph node was palpable. Peau d’orange or orange peel appearance which occurs due to blockage of sub dermal lymphatics by tumour infiltrates, was noted over the skin. Clinically the features were suggestive of inflammatory carcinoma. Mammogram suggested an inflammatory carcinoma. Ultrasound of the breast was suggestive of right duct ectasia and diffusely thickened breast with a Breast Imaging Radiology and Data System (BIRADS) score of 3. An incision biopsy was performed with histopathology confirming the lesion as lymphocytic lobulitis with fibrocystic breast disease. The patient was symptomatically managed with analgesics and reassured. She was observed on regular follow up and is currently healthy. Lymphocytic lobulitis is a rare benign lesion which mimics carcinoma. Clinically it presents with ill defined single or multiple breast lumps in young or middle aged women with thickening and hardening of skin. Magnetic Resonance Imaging better differentiates this otherwise indolent lesion from malignancies. A histopathological examination is usually confirmatory and required to alleviate concerns of patients regarding presence of a malignancy which has a much fearsome physical and psychological implication.
Formulation And Invitro, In Vivo Evaluation Of Mucoadhesive Buccal Tablet Of Enalapril Maleate
Authors: Joan vijetha R  , Balamurugan K
Published: July 2022

The  buccal  area  of  the  mouth  mucosal  cavity  provides  an  adorable  route  of  administration  for  systemic  and  local medication distribution. Among the several transmucosal locations accessible, the mucosa of the buccal cavity was determined to be the most convenient and easily approachable site for the administration of therapeutic drugs as retentive dose forms delivery. The objective of the  current research is based on to improve the bioavailability and efficacy of the Enalapril maleate (EM) a commonly used antihypertensive drug through buccal mucosal. The pure drug EM and excipient polymers such as, hydroxypropyl methylcellulose (HPMC K100), Carbopol 934p, Chitosan and polyvinyl pyrrolidone (PVP K30) were obtained from manufacturing industries. EM buccal tablets were prepared using direct compression. The powder blend formulation studies such as Bulk density, tapped density, Hausner ratio, Carr’s index and angle of repose were carried out, moisture absorption study was performed by using 5%W/V agar, residence time was carried out using porcine buccal mucosa, ex vivo permeation was performed using Franz diffusion cell and in vivo drug release for API and formulated tablets were studies using rabbits. The result of our study showed that the powder flow properties were found to be within the limits, moisture absorption study was 67.63%, residence time till 8.15 hrs, ex vivo permeation 99.12% and in vivo drug release was extended till 24 hrs. The bioregion in which it will remain in contact were perfectly done with appropriate evaluation techniques (Residence time), the moisture absorption study was carried out to check how much moisture the tablet can absorbed to release the drug and was found satisfactory. The ex vivo permeation study was performed by Franz diffusion cell to check the drug permeation through buccal mucosa. The in vivo studies were performed on New Zealand rabbits and can be concluded that the drug release from the formulated F6 was better than the marketed API.
Limiting Criteria for Criminal Liability in Medical Negligence: Refer to the discussion between Germany and Japan
Authors:   Journal of Law research, Hong Tae-Seok
Published: July 2022

It would not be an exaggeration to say that medical accidents occur every day. Medical officials are complaining about the subject of criminal punishment for such medical accidents. Although it will be unfair in many ways from the perspective of the victim who suffered a medical accident, the increase in criminal punishment for medical accidents will be very burdensome for medical workers. Regarding the increase in criminal punishment for such medical accidents, the medical community continues to point out the unfairness.
Regarding criminal punishment for such medical accidents, in Japan, there were also questions about the application of occupational negligence to doctors (the first leaflet of Article 211 of the Japanese Criminal Act) in the wake of the Fukushima Prefectural Ono Hospital incident in 2004. The main reasons for this are that criminal punishment is not necessarily effective in improving doctors' medical technology, securing medical safety, preventing recurrence, and shrinking medical practices due to the imposition of criminal punishment.
Meanwhile, in Germany Jürgens is also pointing out the expansion of criminal punishment for medical personnel. Relief for crime victims is also possible by civil compensation and administrative punishment, but in terms of illegality and accountability, criminal trials should be made and appropriate punishment should be made. However, it seems necessary to consider the specificity of medical practice, consider the disadvantages of criminal punishment for medical personnel, and consider them in various aspects in relation to the scope of negligence. Therefore, in this paper, the contents of discussions in Germany and Japan regarding the limitation of criminal responsibility of doctors were reviewed, and the criteria for limiting criminal responsibility for reasonable medical personnel were reviewed.
KARAKTERISTIK MORFOMETRIK IKAN BAUNG (Hemibagrus hoevenii, Bleeker 1846) DI DESA LANGGAM DAN TAMBAK, SUNGAI KAMPAR, PROVINSI RIAU
Authors: Firiola Sezhianindi , Elvyra Roza
Published: July 2022

Penelitian dilakukan untuk mengetahui perbedaan morfometrik ikan H. Hoevenii jantan dan betina di Desa Langgam dan Tambak Sungai Kampar menggunakan metode survei dengan jumlah sampel sebanyak 60 ekor ikan jantan dan 60 ekor ikan betina di masing-masing lokasi penelitian. Ikan H. hoevenii jantan di desa Langgam memiliki kisaran panjang total 118-214 mm dan betina 129-223 mm sedangan kisaran H. hoeveniii jantan pada Desa Tambak 140-231 mm dan betina 130-270 mm. Hasil uji t menunjukkan terdapat beberapa perbedaan antar karakter H. hoevenii jantan dan betina di Desa Langgam dan Tambak yaitu karakter panjang standar, panjang predorsalm panjang preanal, panjang prepelvic, panjang prepectoral, panjang sirip adiposa, panjang duri pectoral, jaral setelah adiposa, lebar kepala, kedalaman kepala, dan diameter mata.
Edukasi Upaya Deteksi Dini Kanker Serviks di Wilayah Kerja Puskesmas Tahtul Yaman Kota Jambi
Authors: Izhar M.Dody , Butar Butar Marta , Novita Eka Rini Willia
Published: July 2022

Community preparation in carrying out early detection of cervical cancer such as VIA examination in the form of community mobilization (Empowerment) is needed so that awareness, knowledge and ability of IVA examination targets in carrying out VIA examinations increase according to the Ministry of Health in 2015. With this improvement, it is expected to increase the coverage of VIA examinations at the puskesmas, especially in this case at the Tahtul Yaman Health Center. Community service is carried out through socialization in the form of counseling on early detection of cervical cancer and educational training activities for cervical cancer early detection. The results of the socialization of cervical cancer early detection and training on cervical cancer early detection education showed that there was an increase in the knowledge of participants who took part in the activity compared to before and after participating in the training, from 78.33 to 85.56. Statistical results obtained p value = 0.002, meaning that there is a significant difference in the average test scores before being given training and after being given training. It is hoped that there will be the formation of Educational Cadres for Early Detection of Cervical Cancer in the Work Area of the Tahtul Yaman Health Center in Jambi City and the provision of pocket books that are easily understood by the public.
Pemicuan dan Edukasi Masyarakat Tentang Pemananfaatan Sampah Organik Menjadi Pupuk Organik di Desa Pengudang Kecamatan Teluk Sebong Kabupaten Bintan Tahun 2022
Authors: Simbolon Veronika Amelia
Published: July 2022

Garbage is a complex problem and is one of the sanitation problems in the Pengudang Village area. Waste management is carried out by littering or throwing into the sea and burning dry waste. This has the potential to be a source of environmental pollution for the Pengudang Village community. Organic waste that is processed properly and correctly, will improve the quality of the environment and can even increase family income. The purpose of community service is to provide education to the residents of Pengudang Village about the use of organic waste so that they can increase the knowledge and understanding of residents on how to manage household waste. The implementation method consists of the preparation stage, activity plan, activity implementation stage, implementation method and activity relevance. The results of the activity showed that the participants enthusiastically participated in the presentation of socialization material on the use of waste to the implementation of the simulation of making organic fertilizer. Participants in the socialization were involved directly in the process of making organic fertilizers. The fertilizer that has been made is applied to the plants around the residents' houses. Through this community service activity, participants gain knowledge and skills in utilizing household organic waste into organic fertilizer. Management of household waste is the main objective of the activity, so that the residents of Pengudang Village are able to manage household waste independently. The active role of the government is needed in providing intense education to the community so that waste can be controlled starting from the source of the waste
Prediction of Molecular Distribution and Temperature Profile of FCC Process through Molecular-Level Kinetic Modeling
Authors: Chen Zhengyu , Wang Gang , Zhao Suoqi , Zhang Linzhou
Published: July 2022

This work aims to develop a molecular-level process model framework for
simulating the FCC process. The process model consists of the riser,
regenerator, and separation models. A complex molecular-level kinetic
model, containing 3,652 molecules and 8,202 reactions, was developed for
the heavy oil FCC process. The kinetic model was coupled with the riser
model, and the model parameter was tuned by a set of systematic
experimental data from a pilot-scale plant. After that, a two-zone and
two-phase regenerator model was built. The regenerator was combined with
the riser model, and the coupled modeling and process simulation for the
riser-type FCC unit was developed. The results show that the calculated
value of fraction yields and key bulk properties agrees well with the
experimental data. Moreover, the molecular distribution of the product
and temperature profile was also predicted.
Density Functional Studies on the excited states and active sites of sulforaphane
Authors: Wu ShiQuan , Lu Li-Min , Li Li , Liang QiQi , Gao HuaXu , Zhao Xian-Hao , Hu De-Yuan , Tang Tian-Yu , Tang Yan-Lin
Published: July 2022

Sulforaphane is the plant active substance with the best anticancer
effect and antioxidant found in vegetables. In this paper, based on
density functional theory(DFT), the B3LYP/6-311G+(d,p) theoretical level
was used to optimize the molecular structure of sulforaphane in gas
phase.  On the basis of optimization, the first 30 excited states of
molecule in methanol were calculated by time-density functional
theory(TD-DFT) in SMD solvent model. To analy the excited states of
sulforaphane molecule by calculate UV spectrum and hole-electron.
Finally, we predicted the active sites of sulforaphane molecule by
calculating frontier orbital and fukui function. The results show
that: In the UV spectrum, the absorption peaks at 204.4602 and
336.5590nm are the absorption bands of hetero atomic groups of conjugate
molecules, which are generated by n-π* transition and belong to R
absorption band. According to hole-electron analysis, S0→S18 is the
local excitation, and S0→S7, S0→S25 and S0→S29 are the charge transfer
excitation. In addition, the O and S atoms on sulfuryl group of
sulforaphane are the site of electrophilic reaction; the C and S atoms
on the cyanide group are sites of nucleophilic reaction. This study
provides a theoretical basis for better understanding the antioxidant
and anticancer mechanisms of sulforaphane.
Spontaneous hemothorax in a 10-year-old boy with COVID-19.
Authors: Boussetta Abir , Abida Nesrine , Jellouli Manel , gargah tahar
Published: July 2022

Spontaneous hemothorax occurs in the absence of trauma or iatrogenic
causes. Etiologies of spontaneous hemothorax in children include
connective tissue disease, neoplasia and coagulopathy which is
associated with thromboembolic events. We present the case of a
10-year-old chronic hemodialysis patient with spontaneous hemothorax
with a concurrent COVID 19 infection.
Report of Arias Syndrome: Crigler-Najjar syndrome type II (CN-II)
Authors: ANJANKAR ASHISH , CHOUDHARY NAMRATA , DHOK ARCHANA , JHA ROSHAN
Published: July 2022

This case concerns 8-year-old boy who reported the chief complaints of
severe nausea, persistent sore throat and pain in the abdomen.
Laboratory investigation reveals high unconjugated serum bilirubin
levels with normal liver function enzymes. One month of oral
phenobarbital therapy showed an excellent response and lowered
hyperbilirubinemia significantly.
Knowledge, Attitude and Practices among cardiac surgical patients towards Coronavirus Disease (COVID-19) at tertiary care center.
Authors: Meena Danishwar , Chandolia Pramod , Patel Surendra , Sharma Prem Prakash , Das Anupam , Katti Madhusudan , MATHUR ANIRUDH , Gavade Devendra , Sharma Alok
Published: July 2022

Abstract:Purpose: This study was conducted to assess
the Knowledge, Attitude, and Practice (KAP) of cardiac surgical patients
towards the ongoing Coronavirus Disease  (COVID-19) pandemic, as they
are among the high-risk group for morbidity and mortality associated
with COVID-19. Methods: This cross-sectional survey was
conducted from September 2021 to November 2021 at a tertiary care
hospital in western Rajasthan. A total of 88 patients were enrolled, and
a questionnaire was created with 20 questions to assess KAP towards
COVID-19. The KAP of enrolled patients was compared according to age,
gender, place of residence, and education status. Results: A
total of 88 participants completed the survey questionnaire, of whom 41
were male, and 47 were female. The mean age of the participants was 41.5
years. The mean knowledge score of our study group was 21.49±7.42, the
mean attitude score was 4.08±1.84, and the mean practice score was
4.60±0.74. In the subgroup analysis, the difference in the knowledge
score was statistically significant (p<0.05) in different age
groups, however, the attitude and practice scores were comparable for
all the age groups. There was no difference in KAP scores concerning the
gender of the participants. KAP scores were significantly higher for the
participants residing in urban areas than those from rural places. The
KAP scores also showed a statistically significant relationship with the
education status of the population (p<0.001). The knowledge
score of the participants with graduation and above was 32.50±2.31,
whereas the illiterate subgroup scored 13.72±3.15. Similar results were
seen in the attitude and practice scores, with the mean values showing a
gradual rise with the education status of the study population.
Conclusion: This single-center KAP study on COVID-19 among
cardiac patients who are considered high risk was able to postulate a
comprehensive evaluation. The findings suggest that high-risk patients
have decent knowledge scores and an overall optimistic outlook on
surviving the pandemic. However, novel and far-reaching awareness
programs are required for patients who are less educated and reside in
rural areas as they are found to have lower KAP scores.
Keywords: KAP, COVID 19, Cardiac surgery, Knowledge, Attitude,
Practice
A numerical study of Two-Dimensional Magnetized Bioconvective Unsteady fluid flow in two Stretching Parallel Plates with Internal Heating and Chemical Reaction Effects
Authors: Khan Waris , Rasheed Haroon
Published: July 2022

Driven by scientific development, the bio-convection unsteady nanofluid
flow has gained enormous attention in research due to its applications
in various disciplines such as biosensors, biological polymer synthesis,
pharmaceutics, microbial improved oil recovery, and environment-friendly
applications. As such, this study aims to investigate the mixed
bio-convective magnetized and electrically conducting 2-dimensional flow
in view of two extended wall channels subjected to MHD, thermal
radiation, and binary chemical reaction effects. A mathematical
framework is developed underflow of a nonofluid based on certain
conditions. The implication of Soret and Dufour impacts is considered in
the model problem. Such a nonlinear mathematical model is tackled by
invoking similarity solutions for mass conservation, momentum,
temperature, concentration, and micro-organisms expressions. The
dimensionless principles (ODEs) are addressed by the efficacy
Nactsheim-Swigert shooting along with the iteration process, explicitly
through shooting technique (RK-4). The outlines of distinguished
emerging constraints on flow fields are offered through the plotted
graphic visuals. The impact of physical quantities of engineering
interest is offered numerically via tabulated values.
The usability of Isparta-Keçiborlu sulphur mine flotation wastes in the reclamation of highly calcareous sodic soils
Authors: BAHÇECİ Barış , Bahçeci Ìdris
Published: July 2022

This study was carried out on the usability of sulphur mine flotation
wastes (SMFW) in the reclamation of calcareous sodic soils. SMFW are
formed during the mineral ore beneficiation process and are stored in
ponds built around the plant. However, from time to time, there are
complaints that SMFW overflows from ponds and damages the environment.
SMFW is very acidic (pH =1.0) and, according to chemical tests, it
contains free sulphur, iron, and calcium sulphate. Due to these features
of SMFW, it is thought that it can be used in calcareous sodic soil
rehabilitation and also contribute to the solution of the waste
management problem. For this purpose, the field trial was carried out
for three years. The soil improvement tests were carried out in random
blocks with 3 replicates, and 0, 30, 60, 90, and 120 tons of SMFW per
hectare have been used. SMFW raised the infiltration rate of soil by
nearly double. At the same time, the effect of SMFW on sodium leaching
was very rapid, and exchangeable sodium was removed from the upper layer
with 30 cm of leaching water. In conclusion, SMFW improved the physical
properties of sodic soils and established low-cost soil reclamation.
SMFW doses of 30, 60, 90, and 120 tons per hectare provided exchangeable
sodium leach equivalent to 32, 58, 59, and 86 tons of pure gypsum,
respectively, and exchangeable sodium percentage (ESP) decreased
significantly, particularly in the topsoil layer. These results showed
that SMFW can be used in the reclamation of calcareous sodic soils.
Theoretically Proving the Quantization Hypothesis
Authors: Deng James
Published: July 2022

A century ago, the energy quantization hypothesis required to derive
Planck’s formula has been proposed as the foundations of the quantum
theory. So far, this quantization hypothesis still lacks complete
theoretical proof and interpretation, even no answer for why the
quantization occurs. Here Planck’s quantization hypothesis has been
proved completely in pure theoretical methods, and accompanied by a full
interpretation of the related physical laws. A new physical and
mathematical expression of Planck’s law has been achieved. From now on,
the energy quantum presumption is no longer the premise hypothesis of
quantum theory, but the credible conclusion.
The origin of immunity by means of prior infection and vaccination with implications for the origin of species
Authors: Ola Paul
Published: July 2022

Reality has failed to agree with the expectation that vaccines will solve the COVID-19 problem by preventing onward transmission of the coronavirus known as SARS-CoV-2, which followed logical deductions from inflammatory phenomena in which Mechnikov and his contemporaries described immunity as originating from the elimination of pathogens by a system of cells and substances that has since been named the immune system. But upon illustrating the reality in which we are protected from the pathological manifestations that occur in response to the pathogen in immunological phenomena, it was found to be that in which the pathogen does not cause such pathological manifestations through effects that are due to its mere presence but rather through effects that are due to its influence on pathological mechanisms so that immune mechanisms do not protect us from such pathological manifestations by eliminating the pathogen but rather by making asymptomatic hosting of the pathogen possible. And such protection, which occurs in spite of the presence of the pathogen when the conditions from which it originates are present, is obtained by means of infection with the same pathogen through the attenuation of its
Anisohydric characteristics of a rice genotype ‘ARC 11094’ contribute to increased photosynthetic carbon fixation under fluctuating light conditions
Authors: Taniyoshi Kazuki , Tanaka Yu , Adachi Shunsuke , Shiraiwa Tatsuhiko
Published: July 2022

Photosynthetic induction, which is the response of the CO
assimilation rate to a stepwise increase in light
intensity, potentially affects plant carbon gain and crop productivity
in field environments. Although natural variations in photosynthetic
induction are determined by CO supply and its
fixation, detailed factors, especially CO supply, are
unclear. This study investigated photosynthesis at steady and non-steady
states in three rice ( Oryza sativa L.) genotypes: ARC 11094,
Takanari, and Koshihikari. Stomatal traits and water relations in the
plants were evaluated to characterise CO supply.
Photosynthetic induction was higher in ARC 11094 and Takanari than in
Koshihikari owing to an efficient CO supply. The CO
supply in Takanari is attributed to its high stomatal
density, long guard cell length, and extensive root mass, whereas that
in ARC 11094 is attributed to its high stomatal conductance per stoma
and stomatal opening in leaves with insufficient water (i.e. anisohydric
stomatal behaviour). Our results suggest that there are various
mechanisms for realising an efficient CO supply during
the induction response. These characteristics can be useful for
improving photosynthetic induction and, thus, crop productivity in field
environments in future breeding programs.
Using seconds-resolved pharmacokinetic datasets to assess pharmacokinetic models encompassing time-varying physiology
Authors: McDonough Matthew , Stocker Sophie , Kippin Tod , Meiring Wendy , Plaxco Kevin
Published: July 2022

Aim Pharmacokinetics have historically been assessed using drug
concentration data obtained via blood draws and bench-top analysis. The
cumbersome nature of these typically constrains studies to at most a
dozen concentration measurements per dosing event. This, in turn, limits
our statistical power in the detection of hours-scale, time-varying
physiological processes. Given recent advent of in-vivo electrochemical
aptamer-based (EAB) sensors, however, we can now obtain hundreds of
concentration measurements per administration. Our aim in this paper is
to assess the ability of these time-dense datasets to describe
time-varying pharmacokinetic models with good statistical significance.
Methods Here we use seconds-resolved measurements of plasma tobramycin
concentrations in rats to statistically compare traditional one- and
two-compartmental pharmacokinetic models to new models in which the
proportional relationship between a drug’s plasma concentration and its
elimination rate varies in response to changing kidney function. Results
We find that a modified one-compartment model in which the
proportionality between the plasma concentration of tobramycin and its
elimination rate falls reciprocally with time either meets or is
preferred over the standard two-compartment pharmacokinetic model for
half of the datasets characterized. When we reduce the impact of the
drug’s rapid distribution phase on the model, this one-compartment,
time-varying model is statistically preferred over or tied with the
standard two-compartment model for 80% of our datasets. Conclusions Our
results highlight both the impact that simple physiological changes
(such as varying kidney function) can have on drug pharmacokinetics and
the ability of high-time-resolution EAB sensor measurements to identify
such impacts.
Genetic and serological evidence of Crimean-Congo Hemorrhagic Fever Virus circulation in Ticks and Cattle in North Central Nigeria.
Authors: Igah Olanrewaju Eyitayo , N Chinyere, Chinonyerem , Shittu Ismaila , Meseko Clement , Ogo Ndudim Isaac , Natala Audu Joseph , Kabir Junaidu
Published: July 2022

Crimean - Congo haemorrhagic fever virus (CCHFV) is a tick-borne viral
haemorrhagic febrile disease that is highly pathogenic in humans with
enzootic cycle between tick vectors and animal hosts. Human infection
with CCHFV takes the clinical form of viral haemorrhagic disease, a
major health condition but with limited testing in Nigeria. In this
study, blood samples were collected from 333 pastoralists’ cattle in
North Central Nigeria and 1,470 ticks were picked from the animals. For
serology, Enzyme Linked Immuno Sorbent Assay (ELISA) was performed using
a double antigen multi species ELISA kit with sensitivity and
specificity of 98.9% and 95% respectively at 95% confidence interval
to detect IgG antibody to CCHFV in plasma. RT-qPCR virological technique
was used to identify viral antigen in ticks that were pooled based on
location and genus. Four species of ticks were morphologically
identified to parasitize cattle in the sampled location namely;
Rhipicephalus ( Boophilus) decoloratus (34.6%),
Hyalomma truncatum (32.9%), Amblyomma variegatum (24.6%)
and Rhipicephalus sanguineus (8%). The seroprevalence of CCHFV
was found to be 67%. In Kaduna state, 85 of 108 plasma samples tested
positive (78.7%) while in Plateau state 138 of 225 plasma samples
tested positive (61.3%). Of the 41 pools of tick tested for CCHF, one
(1) pool of 35 Rhipicephalus ( Boophilus) ticks (2.4%)
was positive for CCHF virus with qPCR cycle threshold of 31.88. Although
Hyalommaspp. is documented to be the main vector of
CCHFV, in the present investigation, Rhipicephalus (
Boophilus) species was identified to play a role as reservoir of
CCHF. The high seroprevalence of CCHF in livestock underscores the
public health risk associated with CCHFV at the human-animal interface
in Nigeria.
Population-based hospitalization burden estimates for respiratory viruses, 2015-2019
Authors: Zimmerman Richard , Balasubramani GK , D'Agostino Helen , Clarke Lloyd , Yassin Mohamed , Middleton Donald , Silveira Fernanda , Wheeler Nicole , Landis Jonathan , Peterson Alanna , Suyama Joe , Weissman Alexandra , Nowalk Mary Patricia
Published: July 2022

Background: Acute respiratory infections (ARIs) result in millions of
illnesses and hundreds of thousands of hospitalizations annually in the
US. The responsible viruses include influenza, parainfluenza, human
metapneumovirus, coronaviruses, respiratory syncytial virus (RSV), and
human rhinoviruses. This study estimated the population-based
hospitalization burden of 18 respiratory viruses (RV) over 4 years, from
7/1/2015 to 6/30/2019 among adults ≥18 years of age for Allegheny County
(Pittsburgh), Pennsylvania. Methods: We used population-based statewide
hospital discharge data, health system electronic medical record (EMR)
data for RV tests, census data, and a published method to calculate
burden. Results: Among 26,211 eligible RV tests, 67.6% were negative
for any virus. The viruses detected were rhinovirus/enterovirus (2,552;
30.1%), influenza A (2,299; 27.1%), RSV (1,082; 12.7%), human
metapneumovirus (832; 9.8%), parainfluenza (601; 7.1%), influenza B
(565; 6.7%), non-SARS-CoV-2 coronavirus (420; 4.9% 1.5 years of data
available), and adenovirus (136; 1.6%). Most tests were among female
(58%) and white (71%) patients with 60% of patients ≥65 years, 24%
50-64 years and 16% 18-49 years. The annual burden, ranged from
137-174/100,000 population for rhinovirus/enterovirus; 99-182/100,000
for influenza A; 56-81/100,000 for RSV. Among adults <65
years, rhinovirus/enterovirus hospitalization burden was higher than
influenza A; whereas the reverse was true for adults ≥65 years. RV
hospitalization burden increased with increasing age. Conclusions: These
virus-specific ARI population-based hospital burden estimates showed
significant non-influenza burden. These estimates can serve as the basis
for several areas of research that are essential for setting funding
priorities and guiding public health policy.
Oxidation resistance performance of SiC-AlON ceramic composites at high temperature
Authors: Xiao Lai , Xiao Yu , Zhao Xiao , Li Xing , Chen Lv , Xuan Tu , Zhang Ya , Cai Zhen , Wang Xiao
Published: July 2022

The microstructure and oxidation behaviour of the pure AlON ceramics and 8
wt.% SiC-AlON composite were investigated at 700-1500?C. With increasing
oxidation temperature, the surface morphology of two ceramics showed a
change from acicular to flaky-like and then to granular features. With the
addition of nanosized SiC particles, the oxidation resistance of the
ceramics was remarkably enhanced above 1100?C. This is attributed to the
formation of a dense oxide layer composed of Al2O3, SiO2 and mullite, which
could cover the whole matrix and suppress further penetration of oxygen. Due
to the dense oxide layer, the oxidation kinetics of the 8 wt.% SiC-AlON
composites conformed to a parabolic law, while that of the pure AlON
conformed to a linear law. After oxidation at 1500 ?C for 40 h, the weight
gain of the 8 wt.% SiC-AlON composites was 3.07mg/cm2, which was only 22.5%
of that of the pure AlON.
Protein Biomarkers and Cardiovascular Outcomes in People With Type 2 Diabetes and Acute Coronary Syndrome: The ELIXA Biomarker Study
Authors: Gerstein Hertzel C. , Hess Sibylle , Claggett Brian , Dickstein Kenneth , Kober Lars , Maggioni Aldo P. , McMurray John J.V. , Probstfield Jeffrey L. , Riddle Matthew C. , Tardif Jean-Claude , Pfeffer Marc A.
Published: July 2022

OBJECTIVE

To use protein biomarkers to identify people with type 2 diabetes at high risk of cardiovascular outcomes and death.

RESEARCH DESIGN AND METHODS

Biobanked serum from 4,957 ELIXA (Evaluation of Lixisenatide in Acute Coronary Syndrome) trial participants was analyzed. Forward-selection Cox models identified independent protein risk factors for major adverse cardiovascular events (MACE) and death that were compared with a previously validated biomarker panel.

RESULTS

NT-proBNP and osteoprotegerin predicted both outcomes. In addition, trefoil factor 3 predicted MACE, and angiopoietin-2 predicted death (C = 0.70 and 0.79, respectively, compared with 0.63 and 0.66 for clinical variables alone). These proteins had all previously been identified and validated. Notably, C statistics for just NT-proBNP plus clinical risk factors were 0.69 and 0.78 for MACE and death, respectively.

CONCLUSIONS

NT-proBNP and other proteins independently predict cardiovascular outcomes in people with type 2 diabetes following acute coronary syndrome. Adding other biomarkers only marginally increased NT-proBNP’s prognostic value.