bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Red Yeast Rice Residue as an Alternative Feed Ingredient in Growing-Finishing Pig Diets
Authors: Liu Zhengqun , Zhu Longbo , Li Ning , Zheng Zi , Xie Chunyan , Liang Shiyue , Yan Jun , Mu Shuqin
Published: February 2025

This study aimed to evaluate the effects of graded levels of red yeast rice residue (RYRR) on the growth performance, nutrient digestibility, and fecal microbiota of growing-finishing pigs. A total of 144 pigs were randomly allocated into four dietary treatment groups, over a 75-day experimental period. The study comprised a control group and three dietary supplementation groups receiving RYRR. The control (CON) group was fed a two-phase diet tailored to the pigs’ body weight, while the RYRR groups were provided with the CON diet, where corn, soybean meal, puffed soybeans, and wheat shorts were substituted with 5%, 10%, and 20% of RYRR. Supplementation with 10% RYRR enhanced the apparent digestibility of gross energy, dry matter, and crude fiber, while reducing the feed-to-gain ratio and serum triglyceride levels (p < 0.05). Microbiological analyses revealed that short-chain fatty acid-producing bacteria (Anaerotignum and Lachnospiraceae_UCG-009) were biomarkers in pigs fed the RYRR supplementation diets (p < 0.05). These results demonstrated that RYRR supplementation of the diet exerted beneficial effects on promoting nutrient digestibility as well as modulating the fecal microbiota of pigs, and the recommended proportion of RYRR added to the growing-finishing pigs’ diet is 10%.
Geo-Temporal Variation in the Antimicrobial Resistance of Escherichia coli in the Community
Authors: Smit Chloé C. H. , Keighley Caitlin , Rogers Kris , Miyakis Spiros , Taxis Katja , Sanderson-Smith Martina , Nicholas Nick , Robertson Hamish , Pont Lisa G.
Published: February 2025

Background: Antimicrobial resistance (AMR) is a global health challenge with significant global variation. Little is known about the prevalence on a smaller geographical scale. Objectives: This study aimed to explore the geo-temporal variation in antibiotic resistance in Escherichia coli (E. coli) urinary isolates in the Illawarra Shoalhaven region, a region south of Sydney. Methods: Data from urine E. coli isolates from people living in the community were geospatially analysed from 2008 to 2018. The proportion of resistant isolates was mapped by antibiotic type (amoxicillin with clavulanic acid, cefalexin, norfloxacin, and trimethoprim), postcode, and year. Results: Resistance varied by antibiotic, postcode, and over time, with some postcodes showing increased resistance one year and a decrease the following year. Areas with consistently higher resistance included metropolitan, port, and lake regions. We found low resistance in E. coli to amoxicillin with clavulanate, cefalexin, and norfloxacin (<5% to 10–19%) and the highest resistance for trimethoprim (10–19% to 30–39%). Overall, from 2008 to 2018, E. coli resistance to all four antibiotics increased in this region. Conclusions: This study shows temporal and geospatial changes in E. coli AMR over small geospatial areas, indicating the opportunity for geospatial analysis to assist in area-specific empirical treatment guidance.
Bee Pollen Potential to Modulate Ferroptosis: Phytochemical Insights for Age-Related Diseases
Authors: Kacemi Rachid , Campos Maria G.
Published: February 2025

Bee pollen (BP) is one of the richest known natural resources of micronutrients and bioactive phytochemicals. Some captivating bioactivities of BP compounds, although being largely investigated for the latter as individual molecules, remain very scarcely investigated or completely uninvestigated in bee pollen as a whole product. Among the most intriguing of these bioactivities, we identified ferroptosis as a major one. Ferroptosis, a recently discovered form of cell death (connecting oxidative stress and inflammation), is a complex pathophysiological process and one of the most crucial and perplexing events in current challenging human diseases such as cancer, neurodegeneration, and general aging diseases. Many BP compounds were found to intricately modulate ferroptosis depending on the cellular context by inducing this cell death mechanism in malignant cells and preventing it in non-malignant cells. Since research in both fields, i.e., BP and ferroptosis, is still recent, we deemed it necessary to undertake this review to figure out the extent of BP potential in modulating ferroptosis mechanisms. Our research proved that a wide range of BP compounds (polyphenols, phenolamides, carotenoids, vitamins, minerals, and others) substantially modulate diverse ferroptosis mechanisms. Accordingly, these phytochemicals and nutrients showed interesting potential in preclinical studies to lead to ferroptosis-mediated outcomes in important pathophysiological processes, including many aging-related disorders. One of the most paramount challenges that remain to be resolved is to determine how different BP compounds act on ferroptosis in different biological and pathophysiological contexts, either through synergistic or antagonistic behaviors. We hope that our current work constitutes a valuable incentive for future investigations in this promising and very relevant research avenue.
Guarantee Rate Statistics and Product-Moment Correlation Analysis of the Optimal Deformation Allowance for Loess Tunnel in China
Authors: Qian Xinyu , Qiu Junling , Lai Jinxing , Liu Yuhang
Published: February 2025

The relevant value standards for reserved deformation of tunnels with different types of loess soil are not yet perfect. Through mathematical statistics, literature research, and other methods, 148 monitoring sections of loess tunnels with different soil types were investigated. Pearson, Kendall, and Spearman correlation coefficients were used to analyze the influence of surrounding rock grade, moisture content, and burial depth on the deformation law of tunnels, providing reference for the value of reserved deformation for loess tunnels. The research results indicate that: (1) The correlation between soil type and convergence around the tunnel is strong, followed by excavation span, and the correlation between moisture content and burial depth is weak. Therefore, the design of reserved deformation should focus on considering the soil type and excavation span. (2) For loess tunnel sections with class IV surrounding rock, the deformation allowance for cohesive loess and silty loess tunnel sections can be set within 15 cm, and for sandy loess, it can be set within 15–20 cm. (3) For the loess tunnel section with V-grade surrounding rock, the deformation margin can be determined as follows: viscous loess within 15–20 cm, silty loess within 15 cm, and sandy loess within 35–47.5 cm. (4) The moisture content is mainly distributed between 11% and 23%. It is worth noting that in sandy loess sections, the influence of moisture content on tunnel arch settlement is more significant compared to cohesive loess and silty loess sections. (5) The settlement of the arch crown is affected by changes in coverage depth and has discreteness. When the deformation margin is set to 16 cm, the assurance rate can reach 84.6%. Finally, the rationality of the proposed reserved deformation amount was verified through engineering practice. The research results can provide reference for related similar projects.
A Combined 7-Week Strength and Power Training: Effects on Body Composition, Strength, Speed, and Agility in U14 and U16 Youth Elite Soccer Players
Authors: Ferrini Manuele , Asian-Clemente José , Bagattini Gabriele , Suarez-Arrones Luis
Published: February 2025

The aim of this study was to analyze the effects of a 7-week combined strength and power training program on body composition, aerobic capacity, strength, sprint, and agility in elite youth soccer players. Twenty-one players, divided into age groups (U14 and U16), participated in this study. In addition to four training sessions per week (plus matches), the two groups completed a strength training session on Match Day 4 (MD-4) and a power training session on Match Day 2 (MD-2). Before and after the intervention, various tests were conducted, including skinfold measurements, submaximal intermittent shuttle run, eccentric hamstring strength (EHS), countermovement jump (CMJ), single-leg jump (SLJ), sprint test with split times at 10 and 30 m, agility t-test, push-ups, and pull-ups. Our results indicate that a seven-week program of combined strength training led to significant improvements in body composition, EHS, jump performance, and pull-up tests for both groups of players (p < 0.05). Moreover, the U14 group also demonstrated an improvement in the agility test (p < 0.01). The U14 group experienced more substantial gains than the U16 group in agility and push-up performance (p < 0.05). The sprint performance remained unchanged for both groups (p > 0.05), suggesting that specific training is required to improve this quality.
The Influence of Different Heel Heights on Squatting Stability: A Systematic Review and Network Meta-Analysis
Authors: Duan Liuran , Fekete Gusztáv , Ugbolue Ukadike Chris , Zhou Huiyu
Published: February 2025

The back squat (BS) is one of the most effective exercises for enhancing lower limb strength, but an unstable squat can increase shear forces in the lower back. Understanding how to assess the squat stability is useful for avoiding potential sports injury. During the BS, the trunk lean and center of pressure (COP) are relevant to squat safety, and these kinematics can be altered by elevating the heel. However, there is no relevant meta-analysis on the impact of different heel heights on squat stability. This study aims to bridge the gap in the literature by conducting a systematic review and network meta-analysis on how heel elevation affects squat stability. By quantifying the influence of different heel heights on key biomechanical parameters, such as the center of pressure deviation and ankle dorsiflexion, the study provides actionable insights for athletes, trainers, and clinicians. Fourteen articles were included, and the majority of these studies demonstrated that elevated heels (EHs) can reduce COP deviation and trunk lean. In addition, 25 mm heels may be the preferred option for squat stability in the AP direction when COP data and network meta-analysis are combined. However, in the ML direction, the capacity to maintain balance is rather questionable; when ankle peak dorsiflexion is combined, 8 mm heels have higher COP deviation values and 5 mm heels have lower COP deviation values. Regarding limitations, reliance on a single bias assessment tool (Cochrane Risk of Bias Tool) might not fully capture methodological variability across non-RCT studies. Future systematic reviews could consider using multiple bias assessment tools for robust assessment.
Training a Minesweeper Agent Using a Convolutional Neural Network
Authors: Wang Wenbo , Lei Chengyou
Published: February 2025

The Minesweeper game is modeled as a sequential decision-making task, for which a neural network architecture, state encoding, and reward function were herein designed. Both a Deep Q-Network (DQN) and supervised learning methods were successfully applied to optimize the training of the game. The experiments were conducted on the AutoDL platform using an NVIDIA RTX 3090 GPU for efficient computation. The results showed that in a 6 × 6 grid with four mines, the DQN model achieved an average win rate of 93.3% (standard deviation: 0.77%), while the supervised learning method achieved 91.2% (standard deviation: 0.9%), both outperforming human players and baseline algorithms and demonstrating high intelligence. The mechanisms of the two methods in the Minesweeper task were analyzed, with the reasons for the faster training speed and more stable performance of supervised learning explained from the perspectives of means–ends analysis and feedback control. Although there is room for improvement in sample efficiency and training stability in the DQN model, its greater generalization ability makes it highly promising for application in more complex decision-making tasks.
A Review of Lithium–Sulfur Batteries Based on Metal–Organic Frameworks: Progress and Prospects
Authors: Zhu Qiancheng , Sun Weize , Zhou Hua , Mao Deyu
Published: February 2025

Lithium–sulfur batteries (LSBs) are considered candidates for next-generation energy storage systems due to their high theoretical energy density and low cost. However, their practical applications are constrained by the shuttle effect, lithium dendrites, low conductivity, and volume expansion of sulfur. Metal–organic frameworks (MOFs) have emerged as promising materials for addressing these challenges, owing to their exceptional adsorption and catalysis capabilities, coupled with a readily adjustable form-factor design. This review provides a broader perspective by comprehensively examining the applications of MOFs in LSBs, covering their roles in cathodes, separators, and electrolytes from multiple dimensions, including their reaction mechanisms, the development potential of MOFs as cathode materials, and the positive impacts on LSBs’ performance achieved through the preparation of MOFs and modifications of intermediate, separator, and electrolyte. Finally, we provide perspectives on future development directions in this field.
The Emerging Role and Clinical Significance of PI3K-Akt-mTOR in Rhabdomyosarcoma
Authors: Versari Ilaria , Salucci Sara , Bavelloni Alberto , Battistelli Michela , Traversari Mirko , Wang Ashley , Sampaolesi Maurilio , Faenza Irene
Published: February 2025

Rhabdomyosarcoma (RMS) is a common soft tissue sarcoma primarily affecting children and young adults. This disease is more prevalent in children under 15, with two main types: embryonal Rhabdomyosarcoma (eRMS), which has a better prognosis, and alveolar Rhabdomyosarcoma (aRMS), which is more aggressive and associated with specific genetic alterations. The PI3K-Akt-mTOR pathway is often hyperactivated in RMS, contributing to cell proliferation, survival, and resistance to therapies. The presence of phosphorylated components of this pathway correlates with poor survival outcomes. Here, we discuss various therapeutic approaches targeting the PI3K-Akt-mTOR pathway. These include the use of specific inhibitors (e.g., PI3K inhibitors, Akt inhibitors) and combination therapies that may enhance treatment efficacy. Dietary supplements like curcumin and repurposed drugs such as chloroquine are also mentioned for their potential to induce apoptosis in RMS cells. We also emphasize the need for innovative strategies to improve survival rates, which have remained stagnant over the years. Targeting super-enhancers and transcription factors associated with RMS may provide new therapeutic avenues. Overall, this review underscores the critical role of the PI3K-Akt-mTOR pathway in RMS and the potential for targeted therapies to improve patient outcomes.
Morphologic Features and Thermal Characteristics of Nine Cotton Biomass Byproducts
Authors: He Zhongqi , Nam Sunghyun , Tewolde Haile , Ford Catrina V. , Dhandapani Renuka , Barretto Roselle , Wang Donghai
Published: February 2025

Cotton biomass residues consist of an important portion of the agricultural byproducts. In this work, we systematically analyzed and compared the morphology and thermal properties of nine cotton biomass byproducts. The unique tubular and/or porous morphology of some samples (e.g., main stems, branch stems, and petioles) implied their structural advantage in the development of electric supercapacitors and pollutant absorbents. The higher heating values of the nine samples ranged between 17 and 20 MJ kg−1, higher than some of the other common agricultural byproducts (e.g., rice husk and sugarcane bagasse). The moisture content showed a positive correlation (p > 0.05) to the dehydration temperature of the differential scanning calorimetric plots. The residual char after thermogravimetric analysis could be separated into a high-yield cluster (34.4–26.6%) of leaf blades, bracts/peduncles, burrs, defatted meal, and petioles, and a low-yield cluster (20.5–13.6%) of main stems, branch stems, cotton gin waste, and cottonseed hull. These observations and data are useful for a better understanding of the fundamental chemistry of cotton biomass byproducts. Growing knowledge is useful for improving their recycling strategies and may shed light on the exploration of new value-added products or applications from these cotton biomass byproducts for a circular economy with sustainable agriculture.
Identification of Potential Drug Targets for Immunoglobulin A Nephropathy: A Mendelian Randomization Study
Authors: Xiong Limei , Zhang Hui , Guo Yannan , Tao Yuhong
Published: February 2025

Background: The current pharmacological treatments for Immunoglobulin A nephropathy (IgAN) demonstrate limited effectiveness and may cause serious side effects. This study aimed to explore novel potential drug targets for IgAN. Methods: We utilized summarized data from a recent genome-wide association study on IgAN, cis-expression quantitative trait loci data for druggable genes obtained from the eQTLGen Consortium, and DNA methylation quantitative trait loci data derived from the GoDMC database. Two-sample Mendelian randomization (MR) analysis, Bayesian colocalization, and mediation analysis through a two-step MR approach were performed to investigate their causal relationships. Results: Two-sample MR and colocalization analyses demonstrated that the expression of HLA-DPA1 and C4A was associated with an increased risk of IgAN. In contrast, TUBB, CYP21A2, and C4B were associated with a decreased risk of IgAN. Mediation analysis revealed that the expression of HLA-DPA1 acted as a mediator in the potential causal relationship between three DNA methylation sites (cg01140143, cg08898074, and cg12168509) and IgAN, with mediated proportions of 33.74% (95% CI 1.64–73.27), 41.67% (95% CI 20.78–66.97), and 50.34% (95% CI 27.89–74.76), respectively. Conclusions: Several druggable genes and DNA methylation sites were identified to show potential causal associations with IgAN risk and may be targeted for drug development. Nevertheless, additional experimental validation is warranted to clarify the specific roles of DNA methylation and the identified druggable genes in the pathogenesis of IgAN.
Implantable Biosensors for Vascular Diseases: Directions for the Next Generation of Active Diagnostic and Therapeutic Medical Device Technologies
Authors: Alyami Ali Mana , Kirimi Mahmut Talha , Neale Steven L. , Mercer John R.
Published: February 2025

Cardiovascular disease remains the leading cause of morbidity and mortality worldwide. Key challenges such as atherosclerosis, in-stent restenosis, and maintaining arteriovenous access, pose urgent problems for effective treatments for both coronary artery disease and chronic kidney disease. The next generation of active implantables will offer innovative solutions and research opportunities to reduce the economic and human cost of disease. Current treatments rely on vascular stents or synthetic implantable grafts to treat vessels when they block such as through in-stent restenosis and haemodialysis graft failure. This is often driven by vascular cell overgrowth termed neointimal hyperplasia, often in response to inflammation and injury. The integration of biosensors into existing approved implants will bring a revolution in cardiovascular devices and into a promising new era. Biosensors that allow real-time vascular monitoring will provide early detection and warning of pathological cell growth. This will enable proactive wireless treatment outside of the traditional hospital settings. Ongoing research focuses on the development of self-reporting smart cardiovascular devices, which have shown promising results using a combination of virtual in silico modelling, bench testing, and preclinical in vivo testing. This innovative approach holds the key to a new generation of wireless data solutions and wireless powered implants to enhance patient outcomes and alleviate the burden on global healthcare budgets.
The Application of Blockchain Technology in the Field of Digital Forensics: A Literature Review
Authors: Igonor Oshoke Samson , Amin Muhammad Bilal , Garg Saurabh
Published: February 2025

Blockchain technology has risen in recent years from its initial application in finance to gain prominence across diverse sectors, including digital forensics. The possible application of blockchain technology to digital forensics is now becoming increasingly explored with many researchers now looking into the unique inherent properties that blockchain possesses to address the inherent challenges in this sector such as evidence tampering, the lack of transparency, and inadmissibility in court. Despite the increasing interest in integrating blockchain technology into the field of digital forensics and its domains, no systematic literature review currently exists to provide a holistic perspective on this integration. It is a challenge to find a comprehensive resource that examines how blockchain is being applied to enhance the digital forensics process. This paper provides a systematic literature review to explore the application of blockchain technology in digital forensics, focusing on its potential to address these challenges and enhance forensic methodologies. Through a rigorous review process, this paper examines selected studies to identify diverse frameworks, methodologies, and blockchain-driven enhancements applied to digital forensic investigations. The discussion highlights how blockchain properties such as immutability, transparency, and automation have been leveraged to improve evidence management and forensic workflows. Furthermore, this paper explores the common applications of blockchain-based forensic solutions across various domains and phases while addressing the associated limitations and challenges. Open issues and future research directions, including unexplored domains and operational gaps, are also discussed. This study provides valuable insights for researchers, investigators, and policymakers by offering a comprehensive overview of the state of the art in blockchain-based digital forensics, summarizing key contributions and limitations, and identifying pathways for advancing the field.
Using Tangible User Interfaces (TUIs): Preliminary Evidence on Memory and Comprehension Skills in Children with Autism Spectrum Disorder
Authors: De Luca Mariagiovanna , Ilardi Ciro , Dolce Pasquale , Rega Angelo , Fuccio Raffaele , Rubinacci Franco , Gallucci Maria , Marangolo Paola
Published: February 2025

Autism spectrum disorder (ASD) is a complex neurodevelopmental condition involving persistent challenges with social communication, as well as memory and language comprehension difficulties. This study investigated the effects of a storytelling paradigm on language comprehension and memory skills in children with ASD. A traditional approach, using an illustrated book to deliver the narrative, was compared to a novel paradigm based on Tangible User Interfaces (TUIs) combined with multisensory stimulation. A group of 28 children (ages between 6 and 10 years old) was asked to listen to a story over four weeks, two times a week, in two different experimental conditions. The experimental group (n = 14) engaged with the story using TUIs, while the control group (n = 14) interacted with a corresponding illustrated book. Pre- and post-intervention assessments were conducted using NEPSY-II subtests on language comprehension and memory. At the end of the intervention, a trend of improved performance was found. In particular, a greater number of subjects benefited from the intervention in the experimental group compared with the control group in instruction comprehension and narrative memory-cued recall. These preliminary findings suggest that TUIs may enhance learning outcomes for children with ASD, warranting further investigation into their potential benefits.
Guided Firework Algorithm (GFWA) Optimization Research on Viscoelastic Damper (VED) Structure Based on Vulnerability Evaluation
Authors: Wang Xianjie , Lei Chunyu , Xiang Mengjie , Jiang Donghai , Wang Xin
Published: February 2025

The vulnerability curve serves as a precise evaluation metric for structural seismic performance and a critical component in earthquake loss assessment. In this study, the orthogonal expansion method for random ground motion generation is integrated with the probability density evolution method (PDEM) to address the dynamic reliability and vulnerability of general Multi-Degree of Freedom (MDOF) nonlinear structures. By employing dynamic reliability as a constraint and vulnerability as an evaluation index, the guided firework algorithm (GFWA) is introduced to optimize the design of viscoelastic damper (VED) structure systems. To validate the proposed methods, several examples are presented, including the generation of artificial waves, the vulnerability analysis of a five-story reinforced concrete (RC) structure, and a comparative study of GFWA and genetic algorithm (GA) optimization for VED parameters to assess the optimization efficiency. The results demonstrate that the proposed vulnerability method achieves satisfactory accuracy and is well suited for evaluating damper structure optimization designs. Furthermore, GFWA outperforms GA significantly in terms of efficiency and feasibility, offering a promising approach for optimization design in architectural structures.
An Investigation of the Effect of Fissure Inclination on Specimen Deformation and the Damage Mechanism Based on the DIC Method
Authors: Wang Hongwei , Xie Fuxiang , Fu Xi , Wang Yongyan , Yin Zhaoming
Published: February 2025

In order to investigate the effect of fissure inclination on the mechanical properties, deformation, and crack evolution of the surrounding rock in the roadway, uniaxial compression experiments were conducted on sandstone-like materials with prefabricated fissures. The high-speed camera and DIC (digital image correlation) method were employed to analyze the strain distribution and the crack evolution of the specimen. The results demonstrated that the presence of fissures reduces the stress for crack initiation, with intact specimens producing new cracks from about 75% of peak strength and fissured specimens producing new cracks from 50% to 60% of peak strength. The fissure reduced the strength and elastic modulus of the specimen while increasing the strain. The fissure inclination of 45° exhibited the most significant changes compared to the intact specimen. The peak strength and elastic modulus decreased by 54.52% and 35.95%, respectively, and the strain increased by 151.42%. The intact specimen and specimen with 90° inclination are mainly distributed with the shear crack, tensile crack, and far-field crack, which are mainly tensile–tension damage; specimens with 0~75° inclination are mainly distributed with the wing crack, anti-wing crack, oblique secondary crack, and coplanar secondary crack, which are mainly shear slip damage. The direction of the extension of cracks is related to the fissure inclination. For specimens with 0° inclination, the new cracks mainly propagate in the direction perpendicular to the fissure; for specimens with 30° and 45° inclinations, the new cracks mainly propagate in the direction parallel and perpendicular to the fissure; for specimens with 60° and 75° inclinations, the new cracks propagate in the direction parallel to the fissure; and for specimens with 90° inclination, the new cracks propagate in the direction parallel to the fissure.
Parameters for Evolutive Social Housing Projects in Brazil: Contributions from Experiences in Portugal
Authors: Santos Luciana Guimarães Teixeira , Perdigão Ana Kláudia , Roseta Filipa
Published: February 2025

In Brazil, social housing is standardized into two-bedroom units, even when the beneficiary families have been previously identified. In Portugal, despite standardization, housing projects have adopted the concept of evolutionary housing. These are flexible proposals with typological diversity, allowing for a variety of family arrangements. While numerous studies analyze the quality of Brazilian housing projects, few of these studies have directly influenced the reality of the projects implemented. Thus, this study seeks to identify clear and objective parameters that can be applied to the design of social housing projects in Brazil. The evaluation of evolutionary social housing projects used in the resettlement process of Lisbon social neighborhoods was based on the housing program developed by the Laboratório Nacional de Engenharia Civil of Portugal. The findings consist of reference percentages indicating the necessary increases in minimum areas, according to the adopted housing typology, to enable project evolution. By systematizing design practices, this study aims to contribute to the dissemination and application of flexibility as a requirement in the conception of social housing proposals in Brazil, improving the ability to meet residents’ needs and enhancing the quality of life for the most vulnerable populations.
Efficiency of Stochastic Finite Element Random Fields and Variables to Predict Shear Strength of Fiber-Reinforced Concrete Beams Without Stirrups
Authors: Ghannoum Maria , Shamoun Lara , Nasr Dana , Assaad Joseph J. , Riahi Hassen , Khatib Jamal
Published: February 2025

Fibers are widely used in concrete structures to control crack propagation and widening due to sustained or impact loads. Nevertheless, the concrete’s mechanical and structural properties are strongly affected by the fibers’ spatial distribution and clumping tendency within the mass material. The main objective of this paper is to assess the efficiency of stochastic finite element modeling to predict the shear strength properties of fiber-reinforced concrete (FRC) beams without stirrups, as tested by four-point loading. Polypropylene and polyvinyl alcohol micro-filament fibers are investigated in this experimental program at relatively high rates, varying from 0.5% to 1% by volume. A stochastic sensitivity analysis is performed using both random fields and random variables to determine the effect of fiber additions on the concrete’s mechanical properties (i.e., splitting tensile strength and modulus of elasticity) including the beam cracking patterns, ductility, mid-span deflection, and ultimate load. Such data could be of interest to civil engineers and structural designers to reduce the effort and resources needed to assess the FRC strength variability and failure behaviors of structural members.
An Experimental Study on the Seismic Performance of New Precast Prestressed Concrete Exterior Joints Based on UHPC Connection
Authors: Xiong Xueyu , Wei Zhisheng , Zhang Dawei , Liu Ju , Xie Yifan , He Liang
Published: February 2025

Traditional monolithic precast and precast prestressed concrete joints often face challenges such as complex steel reinforcement details and low construction efficiency. Grouting sleeve connections may also suffer from quality issues. To address these problems, a new precast prestressed concrete frame beam-column exterior joint using ultra-high-performance concrete (UHPC) for connection (PPCFEJ-UHPC) is proposed. This innovative joint lessens the amount of stirrups in the core area, decreases the anchorage length of beam longitudinal reinforcement, and enables efficient lap splicing of column longitudinal reinforcement, thereby enhancing construction convenience. Cyclic loading tests were conducted on three new exterior joint specimens (PE1, PE2, PE3) and one cast-in-place joint specimen (RE1) to evaluate their seismic performance. The study concentrated on failure modes, energy dissipation capacity, displacement ductility, strength and stiffness degradation, shear stress, and deformation’s influence on the longitudinal reinforcement anchoring length and axial compression ratio. The results indicate that the new joint exhibits beam flexural failure with minimal damage to the core area, unlike the cast-in-place joint, which suffers severe core area damage. The novel joint exhibits at least 21.7% and 6.1% improvement in cumulative energy consumption and ductility coefficient, respectively, while matching the cast-in-place joint’s bearing capacity. These characteristics are further improved by 5.5% and 10.7% when the axial compression ratio is increased. The new joints’ seismic performance indices all satisfy the ACI 374.1-05 requirements. Additionally, UHPC significantly improves the anchoring performance of steel bars in the core area, allowing the anchorage length of beam longitudinal bars to be reduced from 16 times of the diameter of reinforcement to 12 times.
Mechanical Properties and Constitutive Model of Steel Under Temperature–Humidity Cycles
Authors: Ma Qianying , Feng Dingyu , Li Yu , Yao Boxiang , Wang Lu
Published: February 2025

Through alternating high–low temperature and humid heat tests, six sets of different humidity cycle numbers were applied to Q235B low-carbon steel and Q345B low-alloy steel. Monotonic tensile tests were conducted to compare the differences in monotonic performance degradations. The influence of humidity cycle numbers on the hysteretic and fatigue performance of Q235 steel was investigated through cyclic loading tests. A cyclic constitutive model based on the mixed hardening model was established and validated. The results show that the humid heat environment causes corrosion of the steel, and the degree of corrosion follows a power-law relationship with the number of humid heat cycles. Under monotonic loading, as the number of humid heat cycles increases, the strength and deformation performance of both steels degrade linearly, with Q345 low-alloy steel exhibiting more significant performance deterioration. The corrosion damage induced by the humid heat environment greatly reduces the low-cycle fatigue life of Q235 steel, and the more severe the corrosion, the lower the fatigue life. However, there is no significant effect on the development of the hysteretic curve shape. Under variable amplitude cyclic loading, as the corrosion degree increases, the hysteretic energy dissipation and energy dissipation rate continuously decrease. The two-segment backbone curve considering mass loss rate and the material hardening parameters based on the mixed hardening model can accurately describe the hysteretic characteristics of Q235 low-carbon steel under the humid heat environment.
Time-Dependent Seismic Fragility of Coastal RC Frames Considering Effect of Distance from Coastline
Authors: Yu Xiaohui , Li Zenghui , Yang Ao , Li Yushi , Lu Dagang , Dai Kuangyu
Published: February 2025

Reinforced concrete (RC) structures in coastal atmospheres commonly suffer the penetration of chloride ions, which can lead to the corrosion of reinforcements and, thus, a reduction in their structural performance under earthquakes. In recent years, time-dependent seismic fragility analysis has been widely used as an effective tool to represent the deterioration in the seismic performance of aging RC structures. However, few studies have considered the influences of varying chloride ion exposure environments due to the different distances of structures from a coastline. In light of this, this study performs a time-dependent seismic fragility analysis for aging RC frames, considering varying distances of the buildings from the coastline. To conduct this, a time-dependent reinforcement corrosion rate model that can consider the effect of the distance of a building from the coastline is established by combining a concrete surface chloride ion concentration model, an initial corrosion time model, and an electrochemical corrosion rate model. By integrating material deterioration models for reinforcements and concrete, the seismic fragility relationships for structures with different degrees of corrosion damage can be developed. A corrosion deterioration factor is then proposed to quantify the relationship between the seismic fragility function parameters and the corrosion rate. Subsequently, time-dependent fragility functions considering the effect of the distance from the coastline can be established. A nine-story RC frame designed according to the existing Chinese codes is used for illustration. The time-dependent seismic fragility relationship of the structure is developed considering different distances of buildings from the coastline. The results show that the effect of the distance of a building from the coastline varies under different categories of environment. The seismic fragility results for a structure under a III-a environment are more significantly influenced by the structural distance from the coastline compared to those for a structure under a II-a environment.
Rheological Properties and Permeation Grouting Reinforcement Effect of Cement-Bentonite Slurry
Authors: Wang Yuan , Qi Tian , Xu Chenxi , Gong Jiakun
Published: February 2025

Permeation grouting is one important method for preventing and controlling leakage in levees, with cement-bentonite slurry as a commonly used grouting material. In this study, the effect of water–cement ratio and bentonite content on the rheological properties of cement-bentonite slurry was investigated. The reinforcement effect of cement-bentonite slurry under various conditions was explored by conducting a series of experiments via a self-designed apparatus. The grouting pressure, water–cement ratio, and bentonite content were taken as the grouting variables, and the compressive strength, deformation modulus, and permeability coefficient were adopted as indicators to evaluate the reinforcement effect. The experimental results indicate that the plastic viscosity and the yield stress of the cement-bentonite slurry rose as the water–cement ratio increased. The water–cement ratio served as the main controlling factor of the grouting reinforcement effect. The compressive strength, deformation modulus, and permeability of the grouted body decreased as the water–cement ratio increased. The bentonite content significantly impacted the grouting reinforcement effect. As the bentonite content of slurry increased, the permeability of the grouted body increased, while the compressive strength and deformation modulus first increased then decreased. An optimal bentonite content of cement-bentonite slurry can be decided. Moreover, the failure mode of the grouted body was also significantly impacted by the water–cement ratio. As the water–cement ratio increased, the heterogeneity of the grouted body became greater, and the failure mode changed from overall failure to local failure. The heterogeneity of the grouted body can be improved by enhancing the grouting pressure and the bentonite content of cement-bentonite slurry.
The Association Between Location of BRCA Mutation and Efficacy of PARP Inhibitor as a Frontline Maintenance Therapy in Advanced Epithelial Ovarian Cancer
Authors: Kim Ji Hyun , Kim Se Ik , Kim Eun Taeg , Ha Hyeong In , Lee Dong-eun , Lee Yong Jae , Lee Jung-Yun , Kim Sunghoon , Kim Sang Wun , Kim Young Tae , Park Sang-Yoon , Lim Myong Cheol , Nam Eun-Ji
Published: February 2025

Background: The location of BRCA mutations within functional domains may affect sensitivity to poly (ADP-ribose) polymerase (PARP) inhibitors and platinum-based chemotherapy. This study aimed to evaluate the progression-free survival (PFS) benefit from the PARP inhibitor in relation to the location of mutations in BRCA1/BRCA2 in newly diagnosed ovarian cancer. Materials and methods: Patients with advanced stage III-IV epithelial ovarian cancer who had deleterious BRCA1 or BRCA2 were analyzed. PFS and clinical and molecular data were compared between patients who received olaparib or niraparib as frontline maintenance therapy and those who did not. Subgroup analyses were conducted based on the location of BRCA mutations within the functional domain or the ovarian cancer cluster region (OCCR). Results: Of the 380 patients, 242 (63.7%) harbored BRCA1 mutation, 137 (36.1%) harbored BRCA2, and one (0.3%) harbored both BRCA1 and BRCA2. With a median follow-up of 35.8 months, the DNA binding domain in BRCA1 (HR, 0.34; 95% CI, 0.15–0.79; p = 0.01) and BRCA2 (HR, 0.25; 95% CI, 0.08–0.78; p = 0.01) demonstrated particularly significant benefit. In patients who harbored BRCA1 mutation in the C-terminal domain (BRCT), no statistically significant PFS benefit from PARP inhibitor was observed (HR, 0.76; 95% CI, 0.39–1.52; p = 0.44). PFS benefit from PARP inhibitor maintenance was observed in both OCCR (HR, 0.49; 95% CI, 0.32–0.74; p < 0.01) and non-OCCR (HR, 0.51; 95% CI, 0.27–0.63; p < 0.01). Conclusions: Frontline PARP inhibitor maintenance therapy demonstrated a significant PFS benefit in patients with BRCA1/2 mutations, with particularly pronounced benefits for those with mutations located in the DBD of BRCA1 and BRCA2. However, the benefit was less evident for patients with BRCA1 mutations located in the BRCT domain.
A Prospective, Multicenter, Randomized, Noninferiority Trial of Stopad® Versus Tachosil® for Hemostasis After Liver Resection
Authors: Lim Seung Yeon , Choi Gi Hong , Lim Jin Hong , Han Ho-Seong , Yoon Yoo-Seok , Lee Hae Won , Lee Boram , Park Yeshong , Kang MeeYoung , Kim Jinju , Joo Hyelim , Cho Jai Young
Published: February 2025

Background: Hemostatic products are widely used to control bleeding in hepatic resections. Stopad is a pad-type hemostatic agent containing carboxymethyl chitosan and recombinant thrombin-like hemocoagulase. Methods: We conducted a prospective, multicenter, randomized, noninferiority study of Stopad vs. Tachosil in 104 patients who required open hepatic resection. The subjects were randomized 1:1 to either the investigational group (Stopad; 53) or the control group (Tachosil; 51). Results: The 3-min bleeding control success rate was 92.45% in the Stopad group and 90.20% in the Tachosil group. The lower bound of the one-sided 97.5% confidence level for the between-group difference in the success rate was −9.82%, which was within the preset noninferiority limit of −22.9%. The 5- and 10-min bleeding control success rates were both 100.00% for the Stopad group and were both 98.04% in the Tachosil group. A significantly higher incidence of adverse events was reported in the Stopad group (29/53, 54.72%) than in the Tachosil group (17/51, 33.33%; p = 0.0282). However, the higher number of adverse events in the Stopad group was likely due to a higher proportion of subjects with a past history of surgical or interventional procedure. Conclusions: The hemostatic efficacy of Stopad was noninferior to that of Tachosil in patients undergoing open hepatic resection, introducing new possibilities for more potent hemostatic products in the future. Trial registration number: KCT0004404.
Development of Clinical-Radiomics Nomogram for Predicting Post-Surgery Functional Improvement in High-Grade Glioma Patients
Authors: Ius Tamara , Polano Maurizio , Dal Bo Michele , Bagatto Daniele , Bertani Valeria , Gentilini Davide , Lombardi Giuseppe , D’agostini Serena , Skrap Miran , Toffoli Giuseppe
Published: February 2025

Introduction: Glioma Grade 4 (GG4) tumors, which include both IDH-mutated and IDH wild-type astrocytomas, are the most prevalent and aggressive form of primary brain tumor. Radiomics is gaining ground in neuro-oncology. The integration of this data into machine learning models has the potential to improve the accuracy of prognostic models for GG4 patients. Karnofsky Performance Status (KPS), an established preoperative prognostic factor for survival, is commonly used in these patients. In this study, we developed a nomogram to identify patients with improved functional performance as indicated by an increase in KPS after surgery by analyzing radiomic features from preoperative 3D MRI scans. Methods: Quantitative imaging features were extracted from the -3D T1 GRE sequence of 157 patients from a single center and were used to develop the machine learning (ML) model. To improve applicability and create a nomogram, multivariable logistic regression analysis was performed to build a model incorporating clinical characteristics and radiomics features. Results: We labeled 55 cases in which KPS was improved after surgery (35%, KPS-flag = 1). The resulting model was evaluated according to test series results. The best model was obtained by XGBoost using the features extracted by pyradiomics, with a Matthew coefficient score (MCC) of 0.339 (95% CI: 0.330–0.3483) in cross-validation. The out-of-sample evaluation on the test set yielded an MCC of 0.302. A nomogram evaluating the improvement of KPS post-surgery was built based on statistically significant variables from multivariate logistic regression including clinical and radiomics data (c-index = 0.760, test set). Conclusions: MRI radiomic analysis represents a powerful tool to predict postoperative functional outcomes, as evaluated by KPS.
Nutritional Assessment and Management of Patients with Brain Neoplasms Undergoing Neurosurgery: A Systematic Review
Authors: Pebes Vega Jose Carlos , Mancin Stefano , Vinciguerra Giulia , Azzolini Elena , Colotta Francesco , Pastore Manuela , Morales Palomares Sara , Lopane Diego , Cangelosi Giovanni , Cosmai Simone , Cattani Daniela , Caccialanza Riccardo , Cereda Emanuele , Mazzoleni Beatrice
Published: February 2025

Background/Aim: Nutritional management in neurosurgical patients with brain neoplasms is critical, as optimal nutritional status is potentially associated with improved clinical outcomes. This systematic review aimed to analyze the impact of pre- and postoperative nutritional assessment and effect of prepost interventions on the clinical outcomes. Methods: A systematic review was conducted using the PubMed, Cochrane Library, Embase, and CINAHL databases, complemented by a search of grey literature. Study quality was assessed using the Joanna Briggs Institute framework, and the certainty of evidence was graded according to the Oxford Centre for Evidence-Based Medicine levels. Results: Fourteen studies, encompassing a total of 11,224 adult patients with brain neoplasms, were included. Many of these studies were retrospective, had small sample sizes, and examined diverse nutritional protocols. Preoperative nutritional status assessment, including clinical parameters such as albumin (p < 0.001), Controlling Nutritional Status score (p = 0.001), and Prognostic Nutritional Index (p < 0.010), combined with postoperative oral nutritional supplements (p < 0.001), was significantly associated with postoperative clinical outcomes. Additionally, personalized nutritional counseling contributed to a reduction in complications and facilitated more effective functional recovery. Conclusions: Nutritional care is vital in managing neurosurgical patients with brain neoplasms, reducing complications and enhancing postoperative recovery and overall clinical outcomes. A multidisciplinary team is key to optimal outcomes. Future research should aim to standardize protocols for broader applicability.