bluuebunny/crossref_metadata_2025 huggingface dataset:
Pembuatan Handwasher Ruangan Sistem Otomatis Pada Masyarakat
Authors: Prihatin Joko Yunianto , Pambudi Slamet , Edwin Yoga , Pamungkas Adam Adi
Published: May 2021

Generasi muda karang taruna harus selaras dengan 10 program yang dimiliki oleh PKK ini dapat terlaksana dengan tepat sasaran, yaitu penghayatan dan pengalaman pancasila, gotong royong, pangan, sandang, perumahan dan tata laksana rumah tangga, pendidikan dan keterampilan, kesehatan, pengembangan kehidupan berkoperasi, kelestarian lingkungan hidup dan perencanaan sehat. Perpres No.99, 2017. Tujuan dari kegiatan pengabdian masyarakat ini adalah untuk mampu mencegah meluasnya penyebaran virus corona di wilayah Kelurahan Kratonan dengan program gemar cuci tangan dengan air mengalir di setiap waktu.  Metode yang diterapkan adalah  dengan pembuatan alat automatic indoor handwasher sistem portable dan hemat listrik. Hasil dari kegiatan ini adalah bahwa alat handwasher tersebut sering digunakan di pendopo kelurahan kratonan, sehingga mampu meningkatkan produktifitas kegiatan kemasyarakatan terutama PKK dan Kti menuju kemandirian kampung sehat. Disamping itu kegiatan ini mampu menciptakan teknik lebih baik dalam pengelolaan media fluida air sebagai sumber kehidupan sehat.
Peningkatan Kualitas Juru Las Bengkel Las Rumah Tangga Melalui Pelatihan Dan Sertifikasi
Authors: Triyono  , Cahyono Sukmaji Indro , Muhayat Nurul
Published: May 2021

Banyak juru las industri rumah tangga yang bisa mengelas secara otodikdak namun tidak menguasai teknik pengelasan yang sesuai standard yang ditetapkan oleh asosiasi pengelasan. Untuk itu, tim pengabdian kepada masyarakat Jurusan Teknik Mesin Universitas Sebelas Maret Surakarta bekerja sama dengan Inlastek Welding Institute Surakarta malaksanakan pelatihan juru las untuk meningkatkan mutu produk bengkel las rumah tangga. Pelaksanaan pelatihan pengelasan ini dilakukan dengan standard ISO 9606-1-2013. Pelatihan pengelasan ini dilakukan selama 2 hari di mana materi pelatihan teori diajarkan oleh tim pengabdi UNS karena mempunyai sertifikat Welding Engineer sedangkan materi pelatihan praktek dan uji sertifikasi dilakukan di Inlastek Welding Institute. Hasil pelatihan menunjukkan bahwa ada peningkatan kemampuan pengelasan terutama pengelasan dalam mengelas pelat yang tebal. Selain itu, juru las juga menjadi mengenal jenis-jenis teknik pengelasan yang lebih canggih daripada teknik pengelasan yang ada di bengkelnya.
Ensuring flat heat transfer in heat units of food production
Authors: Ермошин Николай Алексеевич , Романчиков Сергей Александрович , Брагин Артем Николаевич
Published: May 2021

Предлагается способ модификации тепловых блоков пищевых производств с точечным источником генерации теплоты, позволяющий обеспечить плоскостной принцип его передачи на стенки варочного сосуда. Способ обеспечивает повышенную износостойкость и жаропрочность стенок варочного сосуда и теплового блока за счет применения газодинамического напыления запатентованного состава специального покрытия, включающего коллоидный графит, оксид меди, каолин, металлические порошки и мелкодисперсную керамику. Раскрыт порядок нанесения покрытия на стенки теплового блока и варочного сосуда, приводятся физико-химические свойства исходных компонентов керамического жаростойкого покрытия, наносимого на внутренние стенки теплового блока. Предложены образцы теплового оборудования для подготовки исходных компонентов изготовления противоизносного жаростойкого защитного покрытия. Обоснованы условия реализации технических и технологических операций по нанесению покрытий. Исследованы зависимости и получены закономерности изменения теплопередачи и теплопотерь в тепловых блоках пищевых производств в зависимости от состава покрытия и его толщины.

A method is proposed for modifying the thermal blocks of food production with a point source of heat generation, which allows to ensure the plane principle of its transfer to the walls of the cooking vessel. The method provides increased wear resistance and heat resistance of the walls of the cooking vessel and the heat block due to the use of gas-dynamic spraying of a patented composition of a special coating including colloidal graphite, copper oxide, kaolin, metal powders and fine ceramics. The procedure for coating the walls of the heating block and the cooking vessel is disclosed, and the physicochemical properties of the initial components of the ceramic heat-resistant coating applied to the inner walls of the heating block are presented. Samples of thermal equipment for the preparation of the initial components for the manufacture of antiwear heat-resistant protective coating are proposed. The conditions for the implementation of technical and technological operations for coating are substantiated. The dependences are investigated and the regularities of changes in heat transfer and heat losses in the thermal blocks of food production are obtained depending on the composition of the coating and its thickness.
Study of the biocompatibility of lactic acid bacteria and other microorganisms-antagonists isolated from natural sources
Authors: Носкова Светлана Юрьевна , Зимина Мария Игоревна , Бабич Ольга Олеговна , Сухих Станислав Алексеевич , Просеков Александр Юрьевич , Ульрих Елена Викторовна
Published: May 2021

Изучение биосовместимости молочнокислых бактерий и других микроорганизмов-антагонистов, выделенных из природных источников, является актуальной задачей. В данной работе впервые показано взаимное влияние изолятов молочно-кислых бактерий и других микроорганизмов-антагонистов при совместном культивировании. Установлено, что изолят 1 является биосовместимым с изолятами 6, 13, 19 и 20. Изолят 6 активно растет в присутствии изолятов 7, 8, 9, 10, 11, 13 и 16. Изолят 7 биосовместим с изолятами 6, 8, 9, 10, 11, 12, 13, 16, изолят 8 является биосовместимым с изолятами 6, 7, 9, 10, 11, 13 и 16. Для изолята 9 наблюдается биосовместимость с изолятами 6, 7, 8, 10, 11, 12, 13, 16, для изолята 10 - с изолятами 6, 7, 8, 9, 11, 13, 16. Изолят 11 показывает удовлетворительные ростовые характеристики при совместном культивировании с изолятами 6, 7, 8, 9, 10, 12, 13, 16. Изолят 12 биосовместим с изолятами 7, 8, 9, 10, 11, 13 и 16. Изолят 13 является биосовместимым с изолятами 6, 7, 8, 9, 10, 11, 12, 16. Изолят 16 биосовместим с изолятами 6, 7, 8, 9, 10, 11, 12, 13. Изолят 19 является биосовместимым с изолятами 1, 6, 13 и 20, изолят 20 - с изолятами 1, 6, 13 и 19. Полученные результаты позволяют сделать вывод о том, что изоляты 1, 6, 19 и 20 являются близкородственными, так же как изоляты 7, 8, 9, 10, 11, 12, 13 и 16.

The study of the biocompatibility of lactic acid bacteria and other antagonist microorganisms isolated from natural sources is an urgent task. This work shows for the first time the mutual influence of isolates of lactic acid bacteria and other microorganisms-antagonists during co-cultivation. It was found that isolate 1 is biocompatible with isolates 6, 13, 19, and 20. Isolate 6 actively grows in the presence of isolates 7, 8, 9, 10, 11, 13, and 16. Isolate 7 is biocompatible with isolates 6, 8, 9, 10 , 11, 12, 13, 16, isolate 8 is biocompatible with isolates 6, 7, 9, 10, 11, 13 and 16. Isolate 9 is biocompatible with isolates 6, 7, 8, 10, 11, 12, 13, 16, for isolate 10 - with isolates 6, 7, 8, 9, 11, 13, 16. Isolate 11 shows satisfactory growth characteristics when co-cultivated with isolates 6, 7, 8, 9, 10, 12, 13, 16. Isolate 12 is biocompatible with isolates 7, 8, 9, 10, 11, 13 and 16. Isolate 13 is biocompatible with isolates 6, 7, 8, 9, 10, 11, 12, 16. Isolate 16 is biocompatible with isolates 6, 7, 8 , 9, 10, 11, 12, 13. Isolate 19 is biocompatible with isolates 1, 6, 13 and 20, isolate 20 - with isolates 1, 6, 13, and 19. The results obtained suggest that isolates 1, 6, 19 and 20 are closely related as well as isolates 7, 8, 9, 10, 11, 1 2, 13 and 16.
A Study on the variation of Apigenin content in Cardiospermum halicacabum from 21 districts of Tamil Nadu by HPTLC
Authors: Rajasekaran A , Abirami V , Arunkumar S , G Bharani Priya , Gugapriya S , Arivukkarasu R
Published: May 2021

Cardiospermum halicacabum is one of the most potent medicinal plants used in Indian traditional systems of medicine for the treatment of various diseases, mainly for arthritis. Apigenin is one of the major constituent present in Cardiospermum halicacabum. The present study mainly aimed to estimate the content of major constituent apigenin present in Cardiospermum halicacabum collected from 21 districts of Tamil Nadu by HPTLC method using the marker compound apigenin. The HPTLC method was performed using HPTLC aluminium sheets precoated with Silica Gel 60 GF254 as stationary phase and Toluene: Ethyl acetate: formic acid: methanol (3:6:1.6:0.4 v/v) as the mobile phase. The developed chromatogram was scanned at 254nm using Camag Scanner III. The Rf value of standard apigenin and apigenin in the leaf extract of Cardiospermum halicacabum was found to be in the range of 0.80 to 0.89. Plant collected from Cuddalore district of Tamil Nadu was found to contain relatively high amount of marker compound apigenin than other regions.
Comparative study of Insecticide potential of Methyl parathion and diazinon in Drosophila melanogaster
Authors: Sahoo Suman , Acharyya Mausumi Ari , Muniyan Rajiniraja
Published: May 2021

Several reports indicate that many chemical pollutants which are widely spread in the environment, such as insecticide, pesticide and drugs are mutagenic in various test system. These findings reflect an urgent need to draw more attention to the possible genetic hazards of such pollutants to public health. The present investigation of working hypothesis deals with the effects of two insecticides viz. Methyl Parathion (MeP) and Diazinon (DZ) on non-target organism Drosophila melanogaster. We have carried out the chromosomal aberration test with various concentration for insecticides (MeP and DZ) which infer properties like ectopic pairing, inversion loop, puffing, fusion, and asynapsis. Chromosomal aberration result shows significant effects with DZ even in less concentration (0.02ppm) when compared with MeP (0.2ppm). The present study proposes that diazinon is more cytotoxic than methyl parathion in Drosophila melanogaster.
Synthesis of Graphene oxide supported with Bimetallic nanoparticles and its Application
Authors: Andal Perumal , Tamijselvi S. , Pradeep S. , Gayathri K.
Published: May 2021

In this study, a very simple and highly effective mechanochemical preparation method was developed for the preparation of Ni nanoparticles supported graphene oxide (GO). The developed method is not only very simple and efficient, but also, the morphology of Ni/GO nanocomposites can be tuned by simply varying the metal loading. The nanoparticle has an immense assortment of prospective applications in biomedical, optical, and electronic fields. Nanoparticles are of great technological fascination as they are effectively an aqueduct between bulk substances and atomic or molecular structures. The properties of matter change as their size approaches to nanoscale and as the atomic percentage at the material surface becomes significant. For bulk materials larger than one micrometre in size, the rate of particles at the surface is minute relative to the total number of particles of the material. The absorbing and occasionally unpredicted properties of nanoparticles are not partly due to the characteristic of the material surface dominating the properties instead of the bulk properties. In this study, two different graphene oxide supported by two mono Ni Mn and bimetallic Ni\Mn nanoparticles catalyst synthesized. The size and shape of the products were characterised by scanning electron microscopy (SEM) andX-ray diffraction spectroscopy (XRD). Results proved that the newly developed graphene oxide carried nickel-manganese nanoparticles catalysts can be more efficient to reductive, oxidative and environmentally important organic pollutants.
The Effect of Freeze-Drying Procedures on Frangipani Sap Chloroform Extract Quality
Authors: Amin M. N. , Hidayat M. , Permatasari N. , Choiron Moch. A.
Published: May 2021

The water content in the frangipani sap enormously influences the product of the extraction process of natural materials. Before extraction, water content on the herbal material based sap is reduced by using the drying process. This study aimed to analyze the impact of water content reduction through freeze and non-freeze dry in the quality chloroform extract of frangipani sap. This research was designed into two groups to reduce frangipani sap water content through freeze-drying and without freeze-drying. Both groups were extracted by maceration method and chloroform solvents. The result of extraction was seen the physical quality and phytochemical screening through the Thin Layer Chromatography method (flavonoids, anthraquinone, polyphenols, alkaloids, terpenoids, and triterpenoids). Furthermore, the color intensity assay is produced from the Thin Layer Chromatography assay results and then carried out statistical tests. The results of this study are that without the freeze-drying group there is a fungus in the storage period. Both groups do not contain active ingredients flavonoids, anthraquinone, and polyphenols but contain alkaloids, terpenoids, and triterpenoids. The results of the color intensity test on the active ingredients contained showed that the freeze-drying group was higher and there were statistically significant differences in values. The results of this study indicated that chloroform extract of frangipani extract by freeze-drying showed higher quality than non-freeze drying. In the freeze-drying group, it can be found that there were no fungi and had the right color intensity. However, this study requires further study to know the compound properties quantitatively.
In vitro Antioxidant potential, Total Phenolic and Flavonoid contents in Justicia gendarussa leaf extracts
Authors: Kuber B Ramya
Published: May 2021

Free radicals are triggered in human body by routine metabolic pathways which are highly reactive substance entangled in various physiological functions but excess production may impart with multitude diseases such as cancer, arthritis, inflammation and various neurodegenerative disorders. As a result, previous findings supported that various photochemical constituents present in natural plants exerts prominent role in defense mechanism against rate of excess free radicals’ production. The present study was carried out to investigate phytochemical composition, quantification studies and in vitro antioxidant potential of Justicia gendarussa (JG) various solvent extracts. JG belongs to the family Acanthaceace and used as traditional healers in various ailments. JG plant material was collected, dried, powdered and subjected for soxhlation to prepare ethanolic, ethyl acetate, aqueous and n-hexane extracts. Screening of Active constituents by various qualitative tests, estimation of total phenolic (TPC) and Total flavonoid content (TFC) and in vitro antioxidant potential of plant extracts were performed by DPPH, Lipid peroxidation, Nitric oxide and Superoxide radical scavenging methods. Present investigation reveals that, presence of flavonoids, phenols, amino acids, glycosides, cardiac glycosides, proteins, carbohydrates, alkaloids, steroids, terpenoids and tannins. TPC and TFC of ethanol extract were found to be 9.47 ± 0.0216 mg Gallic acid equivalent (GAE/g) and 97.6 ± 0.0342 mg Rutin equivalent/g (RUE/g). Among all the analyzed extracts ethanolic extract of JG possessed high radical neutralizing capacity and for DPPH (IC50 32µg/ml), Lipid Peroxidation (28 µg/ml), Nitric oxide (30 µg/ml) and superoxide anion radicals (39 µg/ml) respectively and found to be more effective as ascorbic acid (26 µg/ml) which was used as standard. Overall results of the study concluded that JG leaf extracts possess beneficial Phytoconstituents, high phenol and flavonoid contents and potential antioxidant activity, which could be a viable source of natural antioxidants for treating various degenerative disorders.
pKa Determination of Carvedilol by Spectrophotometry
Authors: Berkhout Job Herman , H. N. Aswatha Ram , Rathnanand Mahalaxmi
Published: May 2021

Proper knowledge of the pKa value of a compound is of uttermost importance for understanding the behavior of a drug inside the body. The pKa value of Nonselective alpha-1 and beta-blocker Carvedilol shows controversies in literature, whereas values between 7.7 and 8.7 have been previously reported. In this research paper, the pKa value of Carvedilol was re-evaluated using UV-vis spectroscopy. The analytical wavelength used was 241nm. The obtained sigmoid pattern was non-linear fitted using the Boltzmann sigmoidal algorithm. The determined pKa was 7.77 ± 0.09. This value is in accordance with some of the literature publications. Since extensive statistics and multiple replicate experiments were performed, it is assumed that 7.8 is the true pKa value of Carvedilol.
Phytochemical Evaluation and In-vitro Antioxidant Potential of whole plant of Caralluma adscendens
Authors: Yada Divya , Sivakkumar T. , Sudhakar M.
Published: May 2021

The current line of investigation was focused at perusing the presence of phytochemical constituents, investigation of total phenol and flavonoid content, the antioxidant potential of various extracts of Caralluma adscendens whole plant using various in-vitro assays. The dried plant powder was extracted with various solvents based on polarity (Pet ether, Chloroform, Ethyl acetate, Ethanol and Aqueous) by hot continuous extraction in Soxhlet's apparatus and Extracts were dried. Phytoconstituents present in each extract was examined by performing preliminary phytochemical screening. Total Phenolic Content (TPC), Total Flavonoid Content (TFC) and Antioxidant potential for crude extracts were studied by DPPH, nitric oxide scavenging and FRAP methods. The total phenolic content and flavonoid content of Ethanolic extract of plant was found to be 80.08±0.629mg and 70.88±1.170mg of GAE and Quercetin equivalents respectively. The Ethanolic extract exhibited potent antioxidant activity as determined by 2,2-diphenyl-1-picrylhydrazyl(DPPH), nitric oxide scavenging and ferric reducing antioxidant power assays(FRAP) than the other extracts. The IC50 values for the Ethanolic extract of Caralluma adscendens was found to be 214.765±0.224 µg/ml and 215.928±0.506µg/ml by DPPH and nitric oxide scavenging assays respectively.
The effect of Deoxyelephantopin enhances Doxorubicin Sensitivity to
MCF-7 Cancer Cells
Authors: Frengki Frengki , Putra Deddi P. , Wahyuni Fatma Sri , Khambri Daan , Sofia Vivi
Published: May 2021

Deoxyelephantopin is a lactone sesquiterpene compound that shows toxic effects on some cancer cells, otherwise, it is safe on normal cells. The combination of chemotherapy with this compound is intended to determine its effect in increasing the sensitivity of chemotherapy to MCF-7 cancer cells. Cell viability was determined through the MTT method (3-(4,5-dimethyl thiazol-2-il) -2,5-diphenyltetrazolium bromide) to determine the combined effect, while the number of cell deaths was determined through trypan blue staining. Giving deoxyelephantopin-doxorubicin combination to MCF-7 cells showed a synergistic effect with a CI < 0.7. The number of cells that died in the 1.52x and 2.12x combination treatments was higher than the single doxorubicin treatment each at IC50 and ½ IC50 concentrations, this confirms the synergistic effect of the combination. This research proves that deoxyelephantopin can increase the sensitivity and effectiveness of doxorubicin chemotherapy against MCF-7 breast cancer cells.
Formulation and Characterization of Dispersible Tablets of Cefpodoxime Proxetil: A Cephalosporin Antibiotic
Authors: Kumar Naveen , Sarup Prerna , Pahuja Sonia
Published: May 2021

The objective was to formulate rapid dispersible tablets of Cefpodoxime Proxetil using various types of superdisintegrants viz., Croscarmellose sodium (CCS), Sodium starch glycolate (SSG) and Crospovidone (CP) in varied concentrations (1-5%). The model drug for current investigation, Cefpodoxime Proxetil, a broad spectrum third generation Cephalosporin antibiotic belongs to BCS class IV. The preformulation studies were accomplished by determining the compatibility of model drug with respective excipients by FTIR studies. These studies, revealed no chemical interaction of excipients with the model drug. The formulation development was achieved in phases comprising of preliminary screening, pre-optimization and optimization studies. The bitter taste of model drug was masked by addition of flavors and sweeteners to make it pleasant for pediatric patients upon oral administration. The formulations (F1-F6) were prepared by direct compression method. The percent released from all formulations showed release of more than 90% of drug within 30 min with drug content of more than 95%. The study showed that formulation containing CCS as superdisintegrants furnished best results. Formulation F5 showed maximum (99.6%) drug release within 30 minutes which is prerequisite for dispersible tablets. It also possessed a rapid release of drug from the formulation. The F5 formulation showed comparative dissolution profile vis-a-vis a commercialized formulation. The study concluded that dispersible tablets of Cefpodoxime Proxetil can be an alternative to conventional dosage form for the treatment of urinary tract infection, skin infection, and upper respiratory tract infections.
Quercetin Offers Chemopreventive Potential against Breast Cancer by Targeting a Network of Signalling Pathways
Authors: Ahmed Hanaa H. , Aglan Hadeer A. , Elsayed Ghada H. , Hafez Hebatallah G. , Eskander Emad F.
Published: May 2021

This approach was designed to explore the influence of quercetin on distinct molecular pathways implicated in breast cancer evolution. The cytotoxic impact of quercetin on two breast cancer cell lines, MCF-7 and MDA-MB-231 was quantified via MTT assay. The expression levels of the selected genes involved in apoptosis, proliferation, progression, invasion and metastases of breast cancer were analyzed using RT-PCR. The outcomes of the present study explicated that quercetin exhibited suppression effect on MCF-7 and MDA-MB-231 with IC50 = 151 and 958µM respectively after 48 h incubation time. Furthermore, the molecular genetic analysis revealed that quercetin provoked significant downregulation in the expression level of survivin, STAT3, IL-6, VEGF, Slug and MMP7 genes in both cell lines after hours. Meanwhile, MCF-7 exhibited insignificant downregulation in the expression level of Snail and Notch-4 genes after treatment with quercetin. In MDA-MB-231 cells, quercetin evoked insignificant downregulation in the expression level of Snail gene but significant downregulation in the expression level of Notch-4 gene. Conclusively, this work provides scientific clue that quercetin can combat breast cancer through modulating consequential signal transduction pathways engaged in breast cancer development.
Recent Applications of Nanoemulsion Based Drug Delivery System:
A Review
Authors: Eqbal Asif , Ansari Vaseem Ahamad , Hafeez Abdul , Ahsan Farogh , Imran Mohd , Tanweer Saquib
Published: May 2021

Nanoemulsions are drug transporters for the delivery of therapeutic agents. They possess the small droplet size having the range of 20×10-9-200×10-9m. The main purpose of using Nanoemulsion is to enhance the drug bio- availability of transdermal drug delivery system. With the help of phase diagram, we can select the components of nanoemulsion depending upon formulas ratio of oil phase, surfactant/co-surfactant and water phase. Nanoemulsion directly used as a topical drug delivery in skin organs. The most useable pharmaceutical application has been developed till date to provide systemic effects to penetrating the full thickness of skin organ layer nanoemulsions can be administered through variety of routes such as percutaneous, perioral, topical, transdermal, ocular and parental administration of medicaments. Nanoemulsions are transparent and slightly opalescent. Nanoemulsion can be prepared through various methods. Nanoemulsions are transparent and slightly opalescent. Factor affecting nanoemulsions are surfactant, viscosity, lipophilic, drug content, pH, concentration of each component, and methodology of formulation. It is unfeasible to test all factors at the various levels. Design of formulation when it comes to experimental design it gives an excellent approach through reducing the time and money.
Rationalized Approach for The Treatment of Neuropathic Pain
Authors: Chaudhary Srishti , Prashar Pankaj Kumar , Gautam Anamika , Sood Ankita , Singh Sachin Kumar , Gulati Monica , Pandey Narendra Kumar , Kumar Bimlesh
Published: May 2021

Injury to the nerves causes alteration in normal neurobiological sequences lead to disease of somatosensory nervous system called as neuropathic pain (NP). It affects both central as well as peripheral nervous system. It is a chronic painful condition occurs due to various diseases like HIV, diabetes, lesions, infection, trauma, and metabolic insults. NP affects 7-10% of global population, hence subsequently is a major concern. Pharmacotherapy for NP remains a major clinical challenge due to its complex pathophysiology. Current treatments like Analgesics, anticonvulsants, non-steroidal anti-inflammatory drugs, tri-cyclic antidepressants, sodium channel blocker and opioid agonist administrated individually to patients of NP are providing only meager and partial relief. Furthermore, these drugs have limited efficacy as well as adverse effects. Hence instead of monotherapy, pathophysiology of NP suggests that administering multiple drugs (polypharmacy) show quick and sufficient effect in the treatment of NP. Recent updates indicate that combination of Morphine and gabapentin, Pregabalin and duloxetine, Gabapentin and nortriptyline, Amitriptyline and ketamine (topical), Doxepin and capsaicin (topical), Glyceryl trinitrate (topical) and valproate are also a good choice for the treatment of NP. Several clinical trials also established that combination pharmacotherapy showed greater efficacy than monotherapy in treating NP. Physicians, scientists working in the area of NP are not only looking for its treatment but also in resolving the issues of co-morbidities associated with it. Hence the present review focuses on rationalized approach of combination therapy for the treatment of various aspects of NP.
Pengujian Karakteristik Campuran HRS-Base Menggunakan LGA Sebagai Pengganti Aspal Minyak
Authors: Randelabi Dodo P , Rachman Rais , Alpius
Published: May 2021

Penelitian ini bertujuan untuk menganalisis nilai stabilitas, VIM, VFB, MQ dengan subtitusi kadar LGA 0% 2,5%, 5%, 7,5%, 10%, 12,5% dan 15 % terhadap Aspal keras dengan kadar aspal 5% .

Metodologi dalam penelitian ini adalah melakukan serangkaian pengujian karakteristik berupa agregat kasar, agregat halus, filler dan aspal lalu merancang komposisi campuran kemudian membuat benda uji berupa campuran HRS (HRS Base) Kasar serta pengujian Marshall untuk mendapatkan Indeks Perendaman (IP) / Indeks Kekuatan sisa (IKS) / Durabilitas campuran dengan menggunakan kadar aspal optimum. Hasil penelitian yang dilakukan di laboratorium Jalan dan Aspal Fakultas Teknik Jurusan Sipil Universitas Kristen Indonesia Paulus Makassar, menunjukkan penggantian aspal minyak dengan beberapa varian LGA 0%, 2,5%, 5%, 7,5%, 10%, 12,5%, 15% memperoleh nilai Stabilitas, VIM, VFB, VMA, dan MQ. Hasilnya menunjukkan bahwa kadar aspal optimum yaitu 10 % dengan nilai Stabilitas 3083,60 Kg, nilai VIM 0,19 %, VMA 18,602 %, VFB 67,974, MQ 906,88 Kg/mm, dan indeks perendaman (IP) 95,21%.
Vegetation Dynamics and Diversity Status in Mughal Garden Wah, Pakistan
Authors: Ahmad Sheikh Saeed , Gulshad Khansa , Erum Summra , Bashir Hafsa , Ayub Ayesha
Published: May 2021

Classification and ordination of vegetation of Mughal Garden, Wah, Pakistan was done along with assessment of diversity status. A total of 45 species were recorded in vegetation survey belonging to 24 families with Asteraceae and Poaceae being the largest families. Herbs dominated the flora of Wah Garden by 44.4%, shrubs 15.5%, trees 13.3%, grasses 11.1%, creeping herbs 11.1%, ferns 2.2% and aquatic herbs 2.2%. About 35.5% species were annuals, 28.8% perennials, 13.3% annuals or perennials, 8.8% annuals or biennials, 8.8% deciduous, 2.2% coniferous and evergreen species. In case of life form of species, Therophytes and Megaphanerophytes were the most prevalent among species indirect ordination techniques TWINSPAN and DCA were employed that produced two major groups which were further divided into five communities and three major groups, respectively. Shannon-Wiener diversity index, Simpson Index of diversity and Hills N1 and N2 diversity numbers were calculated and verified by data attribute plot through DCA suggesting reduced species diversity as Shannon-Wiener diversity index ranged between 0 and 1.67 due to increased anthropogenic activity. The outcome of this research will be useful in providing information on identification of species that are present, their distribution patterns, and classification which would help in management and conservation of native vegetation in future.
In Vitro Brassica Genotypes Growth Evaluation against NaCl Salt Stress
Authors: Mahmood Imdad Ali , Shahzad Armghan , Ullah Muhammad Arshad , Suhaib Muhammad , Hyder Syed Ishtiaq
Published: May 2021

A hydroponic study was conducted to see the performance of fifteen Brassica genotypes (BARD-I, Sultan Raya, 19-H, Shiralle, Dunkled, 85-508, Toria, 85-499, BSA, 85-397, 85-500, 85-497, 85-5001, CON-I, and Jewel) for their salt tolerance. Four levels of NaCl (0, 30, 60 and 90 mM/L) were developed. One week old two healthy seedlings of each Brassica genotypes were transplanted in holes of thermopole sheet floating over a 200 mL capacity container having half strength Hoagland solution. Increasing the NaCl salinity significantly reduced the shoot and root dry weight of all Brassica genotypes. On an average, about 47% reduction in shoot dry weight was observed under higher salinity level (90 mM/NaCl). Although, all the genotypes differed among themselves in ability to tolerate salinity however, ranking order of genotypes showed that Sultan Raya performed well followed by BARD-I than rest of the genotypes. Genotype 85-500 produced comparatively the least shoot and root dry weights and accumulated more Na+, less K+ and Ca+2 than rest of the genotypes. The reverse was true for Sultan Raya and BARD-I. The farmers could be benefitted through growing the selected comparatively more tolerant genotypes which could grow and survive under salt stress conditions rather than complete crop failure.
Apoptotic Potency of Bawang Dayak(Elutherine americana) Bulb Extract as Inhibitor of BPH through Computational Studies
Authors: Sutapa Hendra , Utomo Didik Huswo , Widodo Mohammad Aris , Purnomo Basuki Bambang , Soebadi Doddy Moesbadianto
Published: May 2021

Benign Prostatic Hyperplasia (BPH) is indicated by hyperproliferation of prostate epithelial and stromal cells. Bawang Dayak (Elutherine americana) is an Indonesian endemic plant which is used as herbal medicine for BPH. This study aimed to reveal the potency of Bawang Dayak bulbs extracts as an inhibitor agent of BPH cells. The research was conducted based on in silica approach. The 3D structure of active compound and protein target were studied and analyzed molecular interaction, calculated binding affinity, and pharmacophore, visualized biomolecules, and analyzed biological activity of each active compound. They are naphthalene, naphthoquinone, and anthraquinone. All active compounds have a higher binding affinity to COX-2. It has the highest binding affinity value around -8.7 Kcal/mol. Anthraquinone has an ability as anti-inflammatory and apoptosis agonist, which blocks the COX-2 active site, so, the Bcl- 2 would be inactivated and apoptosis can occur immediately.

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Detection of Food Poisoning (Bacillus cereus) Pathogen in Cooked and Refrigerated Rice Samples
Authors: Shaikh Shagufta Ambreen , Sidiqui Anila , Naz Shagufta , Ismat Seema
Published: May 2021

Rice is a staple food of Pakistan. It is being contaminated with several food poisoning causing bacterial and mold contaminants. In this study 100 different rice samples were collected from local market of Karachi city. The presence of Bacillus cereus vegetative cell and survival of their spores were quantitavely analyzed after cooking and refrigeration. From the study it was observed that out of 100 rice samples, 25% cooked/refrigerated samples were positive for the presence of B.cereus spores , even there were few samples which showed increase of count due to improper (cooking and refrigeration ) which causes the germination and proliferation of spores into vegetative cells under favorable conditions. The detection of increased count of B. cereus even after cooking and refrigeration treatments is very alarming since cooking is supposed to be best treatment given to the raw food. Different rice dishes are being frequently consumed by the general population and are also available on different shops (as biryanis or fried rice), hence, detection of B. cereus in cooked rice samples will be useful to control any outbreak of food poisoning cases especially in summer seasons.
Antibacterial Activity of Aqueous Extract of Momordica charantia and Terminalia catappa on Multidrug Resistant Invasive Escherichia coli isolated in Ready-to-Eat (RTE) Foods from Ekiti State
Authors: Adeyemi Ajenifuja Oluwafemi , Oluwasegun Ariyo David
Published: May 2021

Antibacterial activity of aqueous extract of Momordica charantia and Terminalia catappa was investigated against multidrug resistant invasive Escherichia coli isolated from ready-to-eat foods such as sausage rolls, meat pie, egg roll, doughnut and smoked fish. From the samples tested, smoked fish was found to have the highest microbial load of 1.05x106cfu/mL (55%) followed by meat pie 7.5x105cfu/mL (37%); Sausage roll 7.0x105cfu/mL (36%); and egg roll with 6.5x105cfu/mL (31%). Doughnut was found to have the lowest microbial load of 58x105cfu/mL (20%). The minimum inhibitory concentration (MIC) of the extract determined by agar dilution technique showed that M. charantia and T. catappa had an MIC of 0.5 g/mL and the degree of antibacterial potency of the extracts determined using broth dilution technique showed that at concentration of 0.5 mg/mL, M. charantia and T. catappa had diameter of zone of inhibition of 10.4mm and 11.2 mm, respectively. The observed antibacterial effect of the T. catappa was more pronounced. This investigation depicts positive results by the use of T. catappa extract in drug development for the treatment of infections caused by E. coli isolated from ready-to-eat foods.
IP CAMERA SURVEILLANCE SYSTEM USING ANDROID APPLICATION BASED ON ARDUINO
Authors: Ayuningtyas Belinda , Ilman Syaeful
Published: May 2021

Keamanan menjadi fokus utama bagi setiap orang, terutama bagi mereka yang memiliki barang berharga. Kamera pengintai merupakan salah satu cara untuk mencegah terjadinya pencurian. Sistem pengawasan telah dirancang dengan menggunakan IP kamera dengan fitur Motion Detection di dalamnya. Fungsi kamera IP adalah untuk mendeteksi dan menangkap gambar dari setiap gerakan dengan menggunakan fiturnya dan mengirimkan snapshot ke situs pengguna melalui FTP (File Transfer Protocol). Selain itu, sensor PIR (Passive InfraRed) yang digunakan sebagai motiondetectorakan dihubungkan ke mikrokontroler Arduino uno dan ethernet shield. Sistem ini juga menggunakan aplikasi pada smartphone android sebagai alert. Jika sensor mendeteksi beberapa gerakan, sensor akan mengaktifkan notifikasi di aplikasi android. Notifikasi di aplikasi android berisi 'Motion Detected check ftp: //ftp.roomsurveillance.info'. Hasil dari sistem surveilans ini berupa snapshot yang dikirimkan oleh kamera IP, dapat dilihat dan diunduh dengan mengklik link FTP. Sistem pengawasan ini dapat meningkatkan keamanan ruangan dalam kondisi realtime.
PERENCANAAN BEBAN PENDINGIN PADA GEDUNG BARU RUMAH SAKIT PMI BOGOR DENGAN METODE CLTD
Authors: Syahrial Edwin , Hadi Sudono Rasyid
Published: May 2021

Sistem HVAC (Heating Ventilating and Air Conditioning) adalah sistem yang berfungsi untuk mengatur suhu dan kelembaban udara pada suatu ruangan, agar suhu dan kelembaban udara pada suatu ruangan menjadi nyaman.Dalam desain beban pendinginan gedung baru 3 lantai , menggunakan metode Cooling Load Temperature Difference (CLTD), dimana suhu dirancang pada suhu 73,4 ℉ dan kelembaban 50%. Dari hasil perhitungan perencanaan beban gedung sebesar 4954985,54 Btu / jam dan suplai udara sebesar 100690,73 CFM. Sistem pemasangan beban pendingin pada gedung menggunakan sistem VRV (Variable Refigerant Volume). Existing menggunakan 10 unit sistem VRV outdoor masing-masing di lantai 1 538642,65 Btu / jam, di lantai 2 dan 3 masing-masing 505004,50 Btu / jam, untuk beban pendinginan yang optimal, dan bangunan menggunakan 215 kasat langit-langit tipe unit dalam ruangan yang telah direncanakan untuk gedung
Çaldıran’da Yetiştirilen Akkaraman Koyunlarının Bazı Verim Özelliklerinin Araştırılması
Authors: TÜRKMEN Cihat , ÇAK Bahattin
Published: May 2021

Bu çalışma; Van ili Çaldıran ilçesinde yetiştirilen Akkaraman koyunlarının döl verimi ile kuzularının büyüme ve yaşama gücü özelliklerinin araştırılması amacıyla yapılmıştır. Araştırmanın hayvan materyalini, Van ili Çaldıran ilçesinde iki farklı özel hayvancılık işletmesinde yetiştirilen 237 Akkaraman koyunu ve bunlardan elde edilen 221 kuzu oluşturmuştur. Kuzuların büyüme ve yaşama gücü özelliklerinin belirlenmesi amacıyla doğum ağırlığı, 15, 30, 60 ve 90. gündeki canlı ağırlıkları ve ölen kuzu sayıları kayıt edilmiştir. Koyunların döl verimi parametrelerini belirlemek için ise gebelik, kısırlık, doğum, abort, tek doğum, ikiz doğum ve kuzu verimi oranları ile bir doğuma kuzu sayısına bakılmıştır. Verilerin istatistiksel analizlerinde en küçük kareler metodu yöntemi kullanılmıştır. Akkaraman kuzularına ait doğum ağırlığı, 15, 30, 60 ve 90. günde tespit edilen canlı ağırlık değerleri sırasıyla 4.29, 6.76, 9.30, 14.44 ve 19.69 kg olarak tespit edilmiştir. Akkaraman kuzularına ait 15, 30, 60 ve 90. gün yaşama gücü değerleri sırasıyla %97.74, 96.83, 96.38 ve 95.92 olarak saptanmıştır. Akkaraman kuzularına ait 30., 60. ve 90. günlük canlı ağırlık artışı ortalamaları ise 167, 169 ve 171 gr olarak belirlenmiştir. Çalışmada gebelik, kısırlık, doğum, abort, tek doğum, ikiz doğum, ve kuzu verimi oranları ile bir doğuma kuzu sayısı sırasıyla %91.14, %8.86, %89.88, %1.39, %96.25, %3.75, %93.25 ve 1.03 olarak tespit edilmiştir. Sonuç olarak; Çaldıran ilçesinde yetiştirilen Akkaraman koyunlarında gerek döl verimi gerekse kuzuların büyüme ve yaşama gücü bakımından tartışılan literatür bulgularıyla benzer durumda oldukları tespit edilmiştir. Bu nedenle, Akkaraman koyununun bölgeye iyi bir adaptasyon göstermeleri ve sahip oldukları avantajları nedeniyle Çaldıran ilçesi şartlarında da yetiştiriciliği yapılabilir.
Analisis Peramalan Stok Barang dengan Metode Weight Moving Average dan Double Exponential Smoothing pada Jovita Ms Glow Lamongan
Authors: Nafi'iyah Nur
Published: May 2021

Jovita MS Glow Lamongan merupakan agen yang menjual produk kecantikan dari brand MS Glow, produk yang dijual di antaranya perawatan wajah, tubuh, kosmetik dengan perkembangan penjualan dari bulan ke bulan semakin meningkat maka dibutuhkan perhitungan perkiraan jumlah barang yang akan dibeli untuk meramalkan persediaan barang bulan berikutnya. Persediaan barang yang tidak tepat dapat menimbulkan kerugian maka perlu adanya sistem peramalan. Oleh karena itu penelitian menggunakan metode Weight Moving Average dan Double Exponential Smoothing untuk menentukan nilai error yang lebih kecil. Data yang digunakan pada penelitian ini mulai bulan Januari 2015 sampai bulan Desember 2016. Metode Weight Moving Average yaitu metode yang memberikan bobot yang berbeda untuk setiap historis sedangkan Metode Double Exponential Smoothing merupakan metode yang memiliki nilai pemulusan dua kali pada waktu sebelum data sebenarnya. Hasil peramalan kedua metode ini menghasilkan nilai error Weight Moving Average yaitu 698.7180 dan Double Exponential Smoothing yaitu 1.429.1015, sehingga Weight Moving Average adalah metode yang tepat digunakan untuk meramalkan persediaan barang karena memiliki nilai error yang lebih kecil.
Multilevel Image Thresholding Memanfaatkan Firefly Algorithm, Improved Bat Algorithm, dan Symbiotic Organisms Search
Authors: Pickerling Pickerling , Armanto Hendrawan , Bastari Stefanus Kurniawan
Published: May 2021

Multilevel image thresholding adalah teknik penting dalam pemrosesan gambar yang digunakan sebagai dasar image segmentation dan teknik pemrosesan tingkat tinggi lainnya. Akan tetapi, waktu yang dibutuhkan untuk pencarian bertambah secara eksponensial setara dengan banyaknya threshold yang diinginkan. Algoritma metaheuristic dikenal sebagai metode optimal untuk memecahkan masalah perhitungan yang rumit. Seiring dengan berkembangnya algoritma metaheuristic untuk memecahkan masalah perhitungan, penelitian ini menggunakan tiga algoritma metaheuristic, yaitu Firefly Algorithm (FA), Symbiotic Organisms Search (SOS), dan Improved Bat Algorithm (IBA). Penelitian ini menganalisis solusi optimal yang didapatkan dari percobaan masing-masing algoritma. Hasil uji coba masing-masing algoritma saling dibandingkan untuk menentukan kelemahan dan kelebihan setiap algoritma berdasarkan performanya. Hasil uji coba menyatakan tiga algoritma tersebut memiliki performa berbeda dalam optimisasi multilevel image thresholding.
Klasifikasi SMS Center RSUD SMART Berdasarkan Jenis Keluhan Pelayanan Menggunakan Naive Bayes
Authors: Rachmatullah Sholeh , Setiawan Esther Irawati , Harianto Reddy Alexandro
Published: May 2021

RSUD SMART memiliki layanan SMS Center yang digunakan untuk berinteraksi dengan masyarakat dalam menerima pertanyaan, masukan, saran dan kritik maupun pengaduan. Informasi yang diterima dalam bentuk sms hanya disimpan dan tidak dikelompokkan berdasarkan unit atau layanan yang dituju sehingga pihak manajemen rumah sakit tidak bisa mengukur tingkat pelayanan di tiap unit. Penelitian ini melakukan klasifikasi terhadap data SMS dan saran responden dari masyarakat yang ditujukan kepada Direktur Rumah Sakit. Data SMS yang diklasifikasi berasal dari database aplikasi SMS Center RSUD SMART Pamekasan. Data SMS dan saran responden diklasifikasikan dalam 10 kelas yaitu Rawat Inap, Rawat jalan, Laboratorium, Farmasi, BPJS, Humas, Loket Pembayaran, Sarana dan Prasarana, Profesi dan tidak Terklasifikasi, serta melakukan scoring sms. Sebelum melakukan proses klasifikasi terlebih dahulu dilakukan pre-processing seperti penyamaan karakter, penghapusan tanda baca, mengembalikan singkatan, terjemah bahasa daerah (Bahasa Madura), penghapusan angka, penghapusan kata yang tidak penting dalam SMS, dan stemming untuk mengubah kata menjadi kata dasar. Penelitian ini menggunakan algoritma Naive Bayes dengan Two Stage (TS) Smoothing. Dalam beberapa uji coba yang telah dilakukan terhadap 2292 data dengan presentase data traning sebesar 20%, 30%, 40% dan 50% mendapatkan rata-rata akurasi sebesar 82,97% dengan nilai λ=0.2, μ=2000 dan threshold=3. Bahkan dalam salah satu uji coba klasifikasi dengan threshold statis mencapai akurasi 86,73% sedangkan akurasi terendah dengan threshold dinamis mencapai 74,28%. Pengaturan threshold statis terbukti meningkatkan akurasi klasifikasi sebesar 6,14%
Cyclic Hematochezia: A Sign of Intestinal Endometriosis? An Evaluation by Magnetic Resonance Imaging and Colonoscopy
Authors: Lüchinger Annemarie B. , Busard Milou P.H. , Mijatovic Velja , van Waesberghe Jan Hein T.M. , Mulder Chris J. , Hompes Peter G.A.
Published: May 2021

Purpose

Intestinal bowel endometriosis is reported in up to 37% of women with proven endometriosis. The aim of this study was to evaluate by colonoscopy and magnetic resonance imaging, patients suspected of deep infiltrating endometriosis (DIE) including the bowel wall that presented with cyclic hematochezia.

Methods

Twenty-four patients with cyclic hematochezia were retrospectively analyzed on colonoscopic features of colonoscopy, corresponding biopsy data, and outcome of magnetic resonance imaging evaluation. Fifteen out of 24 patients underwent bowel resection because of insufficient response to hormonal treatment (N=14) or obstructive ileus (N=1). Outcome of surgery and histologic examination of the resected specimens were evaluated.

Results

Colonoscopy proved intestinal endometriosis in only one out of 24 (4%) patients with cyclic hematochezia. In 13 out of 15 bowel resections endometriosis was found at histopathology. The location and dimension of lesions during surgery correlated well with magnetic resonance imaging findings. However, magnetic resonance imaging revealed a limited capacity to detect luminal narrowing of the bowel.

Conclusions

This study shows that colonoscopic findings of bowel endometriosis are aspecific. Colonoscopy, an invasive investigation, should therefore not be performed to diagnose endometriosis infiltrating the bowel wall. Magnetic resonance imaging provides good diagnostic work-up and in selected patients a roadmap to surgery.
Gastro-Intestinal Symptoms and Dietary Intolerance in Women with Endometriosis
Authors: Baron Yves Muscat , Dingli Maximilian , Agius Rodianne Camilleri , Neville Calleja , Brincat Mark
Published: May 2021

Purpose

A comprehensive assessment of gynecologic, general, and gastrointestinal complaints of a group of women with laparoscopically confirmed endometriosis compared to another group of women without endometriosis was performed. The possibility of dietary intolerance in relation to the coexistence of endometriosis was also assessed.

Methods

This was a prospective, comparative study conducted on 57 patients who had had laparoscopies for various gynecologic complaints. These women were recruited sequentially into the study so as to avoid selection bias (age range 20 to 55). Twenty-three patients were diagnosed with endometriosis while the other 34 did not have this pathology. Prior to laparoscopy these patients were asked through a telephone questionnaire about associated long-term gastrointestinal symptoms, dietary intolerance, and general and gynecologic symptoms.

Results

Twenty-three women were diagnosed as having pelvic endometriosis. The remaining thirty-four patients were noted to suffer from pathology other than endometriosis. Gastro-intestinal symptoms such as dyspepsia (P<.01) and diarrhea (P< .05) were significantly more common in the endometriosis group compared to the other group of women. Women with endometriosis complained of more gastrointestinal symptoms (53% vs. 31%) and food intolerance (26% vs. 14%) than the women without endometriosis. These differences between both groups did not attain statistical significance possibly because the study was not suitably powered to reveal this. No significant differences were noted for most of the other aggregated gynecologic and general symptoms except for shorter menstrual cycles (P<.01) and depression (P<.05) in the women diagnosed with endometriosis.

Conclusions

Patients suffering from endometriosis in this study complained of significantly more gastrointestinal symptoms. A nonsignificant trend of dietary intolerance was noted in the women shown to suffer from endometriosis. These findings may shed some light on the pathogenesis and the management of endometriosis.