bluuebunny/crossref_metadata_2025 huggingface dataset:
In situ Raman and X-ray diffraction studies on the high pressure and temperature stability of methane hydrate up to 55 GPa
Authors: Kadobayashi Hirokazu , Hirai Hisako , Ohfuji Hiroaki , Ohtake Michika , Yamamoto Yoshitaka
Published: April 2018

High-temperature and high-pressure experiments were performed under 2–55 GPa and 298–653 K using in situ Raman spectroscopy and X-ray diffraction combined with externally heated diamond anvil cells to investigate the stability of methane hydrate. Prior to in situ experiments, the typical C–H vibration modes of methane hydrate and their pressure dependence were measured at room temperature using Raman spectroscopy to make a clear discrimination between methane hydrate and solid methane which forms through the decomposition of methane hydrate at high temperature. The sequential in situ Raman spectroscopy and X-ray diffraction revealed that methane hydrate survives up to 633 K and 40.3 GPa and then decomposes into solid methane and ice VII above the conditions. The decomposition curve of methane hydrate estimated by the present experiments is >200 K lower than the melting curves of solid methane and ice VII, and moderately increases with increasing pressure. Our result suggests that although methane hydrate may be an important candidate for major constituents of cool exoplanets and other icy bodies, it is unlikely to be present in the ice mantle of Neptune and Uranus, where the temperature is expected to be far beyond the decomposition temperatures.
2D imaging of helium ion velocity in the DIII-D divertor
Authors: Samuell C. M. , Porter G. D. , Meyer W. H. , Rognlien T. D. , Allen S. L. , Briesemeister A. , Mclean A. G. , Zeng L. , Jaervinen A. E. , Howard J.
Published: April 2018

Two-dimensional imaging of parallel ion velocities is compared to fluid modeling simulations to understand the role of ions in determining divertor conditions and benchmark the UEDGE fluid modeling code. Pure helium discharges are used so that spectroscopic He+ measurements represent the main-ion population at small electron temperatures. Electron temperatures and densities in the divertor match simulated values to within about 20%–30%, establishing the experiment/model match as being at least as good as those normally obtained in the more regularly simulated deuterium plasmas. He+ brightness (HeII) comparison indicates that the degree of detachment is captured well by UEDGE, principally due to the inclusion of E×B drifts. Tomographically inverted Coherence Imaging Spectroscopy measurements are used to determine the He+ parallel velocities which display excellent agreement between the model and the experiment near the divertor target where He+ is predicted to be the main-ion species and where electron-dominated physics dictates the parallel momentum balance. Upstream near the X-point where He+ is a minority species and ion-dominated physics plays a more important role, there is an underestimation of the flow velocity magnitude by a factor of 2–3. These results indicate that more effort is required to be able to correctly predict ion momentum in these challenging regimes.
Bravyi-Kitaev Superfast simulation of electronic structure on a quantum computer
Authors: Setia Kanav , Whitfield James D.
Published: April 2018

Present quantum computers often work with distinguishable qubits as their computational units. In order to simulate indistinguishable fermionic particles, it is first required to map the fermionic state to the state of the qubits. The Bravyi-Kitaev Superfast (BKSF) algorithm can be used to accomplish this mapping. The BKSF mapping has connections to quantum error correction and opens the door to new ways of understanding fermionic simulation in a topological context. Here, we present the first detailed exposition of the BKSF algorithm for molecular simulation. We provide the BKSF transformed qubit operators and report on our implementation of the BKSF fermion-to-qubits transform in OpenFermion. In this initial study of a hydrogen molecule we have compared BKSF, Jordan-Wigner, and Bravyi-Kitaev transforms under the Trotter approximation. The gate count to implement BKSF is lower than Jordan-Wigner but higher than Bravyi-Kitaev. We considered different orderings of the exponentiated terms and found lower Trotter errors than the previously reported for Jordan-Wigner and Bravyi-Kitaev algorithms. These results open the door to the further study of the BKSF algorithm for quantum simulation.
Zinc interstitial threshold in Al-doped ZnO film: Effect on microstructure and optoelectronic properties
Authors: Singh Chetan C. , Panda Emila
Published: April 2018

In order to know the threshold quantity of the zinc interstitials that contributes to an increase in carrier concentration in the Al-doped ZnO (AZO) films and their effect on the overall microstructure and optoelectronic properties of these films, in this work, Zn-rich-AZO and ZnO thin films are fabricated by adding excess zinc (from a zinc metallic target) during their deposition in RF magnetron sputtering and are then investigated using a wide range of experimental techniques. All these films are found to grow in a ZnO hexagonal wurtzite crystal structure with strong (002) orientation of the crystallites, with no indication of Al2O3, metallic Zn, and Al. The excessively introduced zinc in these AZO and/or ZnO films is found to increase the shallow donor level defects (i.e., zinc interstitials and oxygen-related electronic defect states), which is found to significantly increase the carrier concentration in these films. Additionally, aluminum is seen to enhance the creation of these electronic defect states in these films, thereby contributing more to the overall carrier concentration of these films. However, carrier mobility is found to decrease when the carrier concentration values are higher than 4 × 1020 cm−3, because of the electron-electron scattering. Whereas the optical band gap of the ZnO films is found to increase with increasing carrier concentration because of the Burstein-Moss shift, these decrease for the AZO films due to the band gap narrowing effect caused by excess carrier concentration.
Pulsatile pressure driven rarefied gas flow in long rectangular ducts
Authors: Tsimpoukis Alexandros , Valougeorgis Dimitris
Published: April 2018

The pulsatile pressure driven fully developed flow of a rarefied gas through an orthogonal duct is investigated, based on the time-dependent linear Bhatnagar, Gross, and Krook equation, by decomposing the flow into its steady and oscillatory parts. The investigation is focused on the oscillatory part, which is characterized by the gas rarefaction and oscillation parameters, the duct aspect ratio, and the accommodation coefficient. As the oscillation frequency is increased, the amplitude of all macroscopic quantities is decreased, while their phase angle lag is increased reaching the limiting value of π/2. As the gas becomes more rarefied, higher frequencies are needed to trigger this behavior. At small and moderate frequencies, there is a critical degree of gas rarefaction, where a maximum flow rate is obtained. As the duct aspect ratio is decreased and tends to zero, the flow rate and mean wall shear stress amplitudes are increased, while their phase angle lags are slightly affected. The accommodation coefficient has a significant effect on the amplitude and a very weak one on the phase angle of the macroscopic quantities. The computation of the inertia and viscous forces clarifies when the flow consists of only one oscillating viscous region or of two regions, namely, the inviscid piston flow in the core and the oscillating Stokes layer at the wall with the velocity overshooting. Finally, the time average oscillatory pumping power is increased as the oscillation frequency is reduced and its maximum value is one half of the corresponding steady one.
Characterizing single isolated radiation-damage events from molecular dynamics via virtual diffraction methods
Authors: Stewart J. A. , Brookman G. , Price P. , Franco M. , Ji W. , Hattar K. , Dingreville R.
Published: April 2018

The evolution and characterization of single-isolated-ion-strikes are investigated by combining atomistic simulations with selected-area electron diffraction (SAED) patterns generated from these simulations. Five molecular dynamics simulations are performed for a single 20 keV primary knock-on atom in bulk crystalline Si. The resulting cascade damage is characterized in two complementary ways. First, the individual cascade events are conventionally quantified through the evolution of the number of defects and the atomic (volumetric) strain associated with these defect structures. These results show that (i) the radiation damage produced is consistent with the Norgett, Robinson, and Torrens model of damage production and (ii) there is a net positive volumetric strain associated with the cascade structures. Second, virtual SAED patterns are generated for the resulting cascade-damaged structures along several zone axes. The analysis of the corresponding diffraction patterns shows the SAED spots approximately doubling in size, on average, due to broadening induced by the defect structures. Furthermore, the SAED spots are observed to exhibit an average radial outward shift between 0.33% and 0.87% depending on the zone axis. This characterization approach, as utilized here, is a preliminary investigation in developing methodologies and opportunities to link experimental observations with atomistic simulations to elucidate microstructural damage states.
On the annealing-induced enhancement of the interface properties of NiO:Cu/wet-SiOx/n-Si tunnelling junction solar cells
Authors: Yang Xueliang , Liu Wei , Chen Jingwei , Sun Yun
Published: April 2018

Using metal oxides to form a carrier-selective interface on crystalline silicon (c-Si) has recently generated considerable interest for use with c-Si photovoltaics because of the potential to reduce cost. n-type oxides, such as MoO3, V2O5, and WO3, have been widely studied. In this work, a p-type oxide, Cu-doped NiO (NiO:Cu), is explored as a transparent hole-selective contact to n-Si. An ultrathin SiOx layer, fabricated by a wet-chemical method (wet-SiOx), is introduced at the NiO:Cu/n-Si interface to achieve a tunnelling junction solar cell. Interestingly, it was observed that the interface quality of the NiO:Cu/wet-SiOx/n-Si heterojunction was dramatically enhanced by post-deposition annealing (PDA) at a temperature of 200 °C. Our device exhibits an improved power conversion efficiency of 10.8%, which is the highest efficiency among NiO/Si heterojunction photo-electric devices to date. It is demonstrated that the 200 °C PDA treatment enhances the built-in field by a reduction in the interface density of states (Dit) but does not influence the work function of the NiO:Cu thin layer. This stable work function after the PDA treatment is in conflict with the changed built-in field according to the Schottky model. Thus, the Bardeen model is introduced for this physical insight: the enhancement of the built-in field originates from the unpinning of the Fermi levels of NiO:Cu and n-Si by the interface state reduction.
Role of ion magnetization in formation of radial density profile in magnetically expanding plasma produced by helicon antenna
Authors: Yadav Sonu , Ghosh Soumen , Bose Sayak , Barada Kshitish K. , Pal Rabindranath , Chattopadhyay Prabal K.
Published: April 2018

Experimentally, the density profile in the magnetic nozzle of a helicon antenna based plasma device is seen to be modified from being centrally peaked to that of hollow nature as the external magnetic field is increased. It occurs above a characteristic field value when the ions become magnetized in the expansion chamber. The density profile in the source chamber behind the nozzle, however, remains peaked on-axis irrespective of the magnetic field. The electron temperature there is observed to be hollow and this nature is carried to the expansion chamber along the field line. In the electron energy distribution near the off axis peak location, a high energy tail exists. Rotation of these tail electrons in the azimuthal direction due to the gradient-B drift in the expansion chamber leads to an additional off-axis ionization and forms the hollow density profile. It seems that if the ions are not magnetized, then the off-axially produced additional plasma is not confined and the density profile retains the on-axis peak nature. The present experiment successfully demonstrates how the knowledge of the ion magnetization together with tail electrons significantly contributes to the design of an efficient helicon plasma based thruster.
The expression of Transmembrane Protein 100 is regulated by alterations in calcium signaling rather than endoplasmic reticulum stress
Authors: Kuboyama Ayane , Sasaki Takashi , Shimizu Makoto , Inoue Jun , Sato Ryuichiro
Published: April 2018

Transmembrane protein 100 (TMEM100) comprises 134 amino acid residues and is highly conserved among vertebrates. Tmem100 has been recently reported as a key factor in angiogenesis, pain transmission, and tumor suppression. Although the importance of TMEM100 function is well supported, few studies have elucidated its expression mechanism. In the current study, we found that activating transcription factor 6α, a transcription factor activated by endoplasmic reticulum (ER) stress, enhanced Tmem100 promoter activity. Two ER stress response element-like motifs were identified in the mouse Tmem100 promoter region. However, additional experiments using another type of ER stress inducer demonstrated that calcium signaling was more important than ER stress in the regulation of TMEM100 expression. Intracellular calcium signaling controls biological processes such as cell proliferation and embryonic development. This study suggested that TMEM100 performs various functions in response to alterations in calcium signaling in addition to those in response to ER stress.
The Royal Martyr Discover'd: Thomas Pierce and Nicholas Lanier
Authors: Pinto David
Published: April 2018

An overlooked pamphlet of Thomas Pierce's civil-war Latin polemic appends four unascribed English verse-texts dated 1647-9. Pierce's contemporary Anthony Wood ascribed them to him, and named musical setters: William Child, Nicholas Lanier, and Arthur Phillips. Ejected for royalism from Magdalen College, Oxford, Pierce returned as its Restoration President. In 1649, though, why would Lanier, Master of the King's Music, have set a then-ousted don's ‘Funeral Hymn’ for Charles I?
RETRACTED: Authorship Identification for Tamil Classical Poem using Subspace Discriminant Algorithm
Authors: Pandian A , Ramalingam V V , Manikandan K , Vishnu Preet R P
Published: April 2018

The Development of extensive perceiving confirmation of a creator's work consolidates stylometry examination that joins various fascinating issues. Extraction of specific kind of highlights from the substance draws in us with the chance to perceive the producers of obscure works. Center of this paper is to briefly recognize the creators of unidentified Tamil dataset in context of crafted by known creators. Content preparing is the technique for getting amazing data from the dataset that joins quantifiable highlights from the dataset. This paper proposes content preparing method to concentrate features and perform grouping on the same. Crafted by a unidentified sonnet or content can be discovered in light of performing arrangement on potential creators' past known work and building a classifier to characterize the obscure lyric or content in any dialect. This procedure can be additionally reached out to every single provincial dialect around the globe. Numerous writing analysts are thinking that it’s hard to sort ballads as the writers of them are not recognized. By playing out this procedure, creators of different lyrics in Tamil vernacular can be perceived which will be significant to the general public.
RETRACTED: Survey on diagnosis of diseases from retinal images
Authors: Das Sneha , Malathy C
Published: April 2018

Retina is a thin membranous layer of tissue that occupies at the back of the eye which provides central vision needed for daily routines. Identifying retinal diseases at the early stage is a challenging task since healthy retina is required for central vision. Several retinal diseases affect the eye such as retinal tear, retinal detachment, glaucoma, macular hole and macular degeneration etc. These maladies will encounter a secondary growth in the close future as the age of the person increases. A survey is made which tells about the diagnosis of the retinal diseases from the retinal images using machine learning techniques.
GenomicScores: seamless access to genomewide position-specific scores from R and Bioconductor
Authors: Puigdevall Pau , Castelo Robert
Published: April 2018

Genomewide position-specific scores, such as those estimating conservation, constraint, fitness or mutation tolerance, are ubiquitous in current genome analyses. The diversity of sources and formats of these scores, as well as their size, increase the burden to use them. We present GenomicScores, a Bioconductor package that provides efficient storage and seamless access of genomewide position-specific scores from R, facilitating their use in genome analysis workflows.

Availability and implementation

GenomicScores is implemented in R and available at https://bioconductor.org/packages/GenomicScores under the open source ‘Artistic-2.0’ license.

Supplementary information

Supplementary data are available at Bioinformatics online.
Mice lacking all of the Skint family genes
Authors: Narita Tomoya , Nitta Takeshi , Nitta Sachiko , Okamura Tadashi , Takayanagi Hiroshi
Published: April 2018

γδT cells develop in the thymus and play important roles in protection against infection and tumor development, but the mechanisms by which the thymic microenvironment supports γδT cell differentiation remain largely unclear. Skint1, a B7-related protein expressed in thymic epithelial cells, was shown to be essential for the development of mouse Vγ5Vδ1 γδT cells. The Skint family in mouse consists of 11 members, Skint1-11. Here we generated mutant mice lacking the entire genomic region that contains all of the Skint genes. These mice exhibited a marked reduction of Vγ5Vδ1 γδT cells in the thymus and skin, but surprisingly, had normal development of other γδT cell subsets and leukocytes including αβT, B and myeloid cells. This phenotype is essentially identical to that of Skint1-deficient mice. These results indicate that the Skint family exerts an exclusive function in regulating the development of Vγ5Vδ1 γδT cells and is dispensable for development of other leukocytes.
Antinuclear Antibodies: Marker of Diagnosis and Evolution in Autoimmune Diseases
Authors: Sur Lucia M , Floca Emanuela , Sur Daniel G , Colceriu Marius C , Samasca Gabriel , Sur Genel
Published: April 2018

Antinuclear antibodies (ANAs) are autoantibodies that attack self-proteins within cell nucleus structures; their presence in serum may indicate an autoimmune disease. Also, positive ANA test results have been obtained in chronic infectious diseases, cancers, medication-related adverse events, and even healthy individuals. As a result, a correct interpretation of the presence of ANAs is needed.

Identification of ANAs subtypes is an important part of clinical immunology. The presence of ANAs in patient blood specimens is detected using a cell-line substrate from human laryngeal carcinoma (HEp-2 cells). On this substrate, ANAs will bind specific antigens, which will lead to a suggestive fluorescent emission. The fluorescence patterns visualized under the fluorescence microscope can be correlated with certain subtypes of ANA and certain autoimmune diseases.

Depending on the subtype of ANA present in the serum and the targeted antigen, several staining patterns are reported, namely, nuclear patterns, nucleolar patterns, cell cycle patterns, or cytoplasmatic patterns. Identification of a certain pattern can lead to diagnosis of a certain autoimmune disease.
Outcomes of Transvaginal High Uterosacral Ligaments Suspension: Over 500-Patient Single-Center Study
Authors: Milani Rodolfo , Frigerio Matteo , Cola Alice , Beretta Carlo , Spelzini Federico , Manodoro Stefano
Published: April 2018

Background

Uterosacral ligament (USL) suspension is a safe and effective procedure in terms of anatomical, functional, and subjective outcomes for primary surgical treatment of prolapse.

Objectives

There has been a renewed interest toward native tissue prolapse repair by vaginal route because of low cost and lack of mesh-related complications. Uterosacral ligaments are considered safe, effective, and durable as suspending structures for primary surgical repair of the apical compartment. Our aim was to evaluate complications, anatomical, functional and subjective outcomes of high USL suspension for primary prolapse repair.

Methods

Data of patients who underwent vaginal hysterectomy followed by high USL suspension for pelvic organ prolapse were retrospectively analyzed. Operative data, as well as complications, were recorded. Anatomical recurrence was defined as descent of any compartment stage II or greater according to the Pelvic Organ Prolapse Quantification system. Functional outcomes focused on urinary, bowel, and sexual dysfunctions. International Consultation on Incontinence Questionnaire–Urinary Incontinence Short Form, Wexner, and Patient Global Impression of Improvement questionnaires were collected.

Results

Data of 533 women were analyzed. Mean follow-up was 32 (SD, 19) months (dropout rate, 2.6%). Most frequent complication was ureteral kinking (2.6%). Total recurrence rate was 13.7%, with anterior compartment being the most frequent (9.4%), whereas reoperation for symptomatic prolapse recurrence was required in only 1% of patients. Improvement of urinary incontinence, voiding dysfunction, constipation, and dyspareunia was observed. Overall subjective satisfaction was high (Patient Global Impression of Improvement score, 1.3), ranging from “much improved” to “very much improved.”

Conclusions

Uterosacral ligament suspension is a safe and effective procedure in primary surgical treatment of pelvic organ prolapse. Anatomical, functional, and subjective outcomes were very satisfactory, and reoperation rate for recurrence was only 1%.
A Fine Balance: How Authors Strategize Around Journal Submission
Authors: Ginsburg Shiphra , Lynch Meghan , Walsh Catharine M.
Published: April 2018

Purpose

Publishing in peer-reviewed journals is essential for medical education researchers. Competition remains fierce for top journals, and authors are advised to consider impact factor (IF), audience, and alignment of focus. However, little is known about how authors balance these factors when making submission decisions. The authors aimed to explore decision making around journal choice.

Method

Using constructivist grounded theory, the authors conducted and analyzed 27 semistructured phone interviews (August–November 2016) with medical education researchers. Participants were recruited from a larger study, and all had presented abstracts at medical education meetings in 2005 or 2006.

Results

When deciding where to submit an article, participants weighed a journal’s IF and prestige against other factors, such as a journal’s vision and mission, finding the right audience, study-specific factors including perceived quality of the work, and the peer review process. The opportunity cost of aiming high and risking rejection was influenced by career stage and external pressures. Despite much higher IFs, clinical journals were viewed as less desirable for establishing legitimacy in the medical education field and were often targeted for less novel or rigorous work. Participants expressed dissatisfaction with peer review in general, citing overly critical and poorly informed reviewers.

Conclusions

Authors strategize around a particular article’s submission by attempting to balance many interrelated factors. Their perceptions that high-IF clinical journals are viewed as less prestigious in this field can lead to publication strategies running counter to advice given to junior faculty. This has implications for mentorship and institutional leadership.
OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY IN THE DIAGNOSIS AND FOLLOW-UP OF RETINAL ARTERIAL MACROANEURYSMS
Authors: Astroz Polina , Miere Alexandra , Cohen Salomon Yves , Querques Giuseppe , Souied Eric H.
Published: April 2018

Purpose:

To describe optical coherence tomography angiography (OCTA) findings in retinal arterial macroaneurysm (RAM) associated with macular edema and to correlate OCTA findings with conventional multimodal imaging.

Methods:

The clinical course, conventional multimodal imaging findings including fundus color photography, spectral domain optical coherence tomography (Spectralis; Heidelberg Engineering, Heidelberg, Germany), fluorescein angiography (Heidelberg Engineering), and OCTA (Optovue, Inc, Freemont, CA) findings at baseline and during the follow-up of two eyes (two patients) with symptomatic RAM associated with macular edema were documented.

Results:

Two eyes of 2 patients, both women, aged 82 and 46 years, which presented with progressive visual decline, were included. On conventional multimodal imaging, exudative RAM with macular edema and lipid exudation were visible in both included eyes. On OCTA, the flow in the two RAM was detected at baseline. Case 1 was treated by focal laser photocoagulation. One month after treatment, fluorescein angiography showed RAM occlusion. Spectral domain optical coherence tomography showed a RAM and retinal thinning and a decreased central foveal thickness, resulting in visual acuity improvement. On OCTA, no flow was detectable in the RAM at 1-month follow-up. Case 2 was not treated at baseline. In this eye, no flow was detected on OCTA at 2-month follow-up. This suggests a spontaneous occlusion, which was confirmed by fluorescein angiography.

Conclusion:

Optical coherence tomography angiography is able to detect the presence or absence of flow signal within RAMs, which may both decrease the need for dye angiography in selected cases with exudative RAM and help in treatment decision making.
Improved Progression Prediction in Barrett’s Esophagus With Low-grade Dysplasia Using Specific Histologic Criteria
Authors: ten Kate Fiebo J.C. , Nieboer Daan , ten Kate Fiebo J.W. , Doukas Michail , Bruno Marco J. , Spaander Manon C.W. , Looijenga Leendert H.J. , Biermann Katharina
Published: April 2018

Risk stratification of patients with Barrett’s esophagus (BE) is based on diagnosis of low-grade dysplasia (LGD). LGD has a poor interobserver agreement and a limited value for prediction of progression to high-grade dysplasia or esophageal adenocarcinoma. Specific reproducible histologic criteria may improve the predictive value of LGD. Four gastrointestinal pathologists examined 12 histologic criteria associated with LGD in 84 BE patients with LGD (15 progressors and 69 nonprogressors). The criteria with at least a moderate (kappa, 0.4 to 0.6) interobserver agreement were validated in an independent cohort of 98 BE patients with LGD (30 progressors and 68 nonprogressors). Hazard ratios (HR) were calculated by Cox proportional hazard regression analysis using time-dependent covariates correcting for multiple endoscopies during follow-up. Agreement was moderate or good for 4 criteria, that is, loss of maturation, mucin depletion, nuclear enlargement, and increase of mitosis. Combination of the criteria differentiated high-risk and low-risk group amongst patients with LGD diagnosis (P<0.001). When ≥2 criteria were present, a significantly higher progression rate to high-grade dysplasia or esophageal adenocarcinoma was observed (discovery set: HR, 5.47; 95% confidence interval [CI], 1.81-17; P=0.002; validation set: HR, 3.52; 95% CI, 1.56-7.97; P=0.003). Implementation of p53 immunohistochemistry and histologic criteria optimized the prediction of progression (area under the curve, 0.768; 95% CI, 0.656-0.881). We identified and validated a clinically applicable panel of 4 histologic criteria, segregating BE patients with LGD diagnosis into defined prognostic groups. This histologic panel can be used to improve clinical decision making, although additional studies are warranted.
Pediatric Veno-Veno Extracorporeal Membrane Oxygenation Rescue From Carbon Monoxide Poisoning
Authors: Baran David A. , Stelling Kelly , McQueen Derrick , Pearson Mark , Shah Vaishali
Published: April 2018

Background

Carbon monoxide poisoning affects approximately 5000 children per year and can be challenging to diagnose and treat (Pediatr Emerg Med Pract. 2016;13:1–24). It is in the differential diagnosis of a patient presented with altered consciousness. Patients may look quite “pink” and well perfused, but are often in serious distress. We present the first case in the literature of carbon monoxide poisoning treated with the use of veno-veno extracorporeal membrane oxygenation (ECMO).

Case

We report the case of a 10-year-old patient who had carbon monoxide poisoning (carboxyhemoglobin of 18%). She was treated with hydroxocobalamin at 70 mg/kg and was being prepared to transfer to a facility that offered hyperbaric therapy when she suffered a cardiac arrest requiring cardiopulmonary resuscitation. After 11 minutes of resuscitation, she had return of spontaneous circulation and an echocardiogram showed reasonable cardiac function. She was judged too unstable for ambulance transport and the ECMO team was called. Veno-veno ECMO was placed via a single right internal jugular dual-lumen catheter with fluoroscopy in the cardiac catheterization laboratory. There was a rapid improvement in carboxyhemoglobin level, and the ECMO therapy was weaned the next day. The patient eventually made a full recovery.

Conclusions

This is the first time that veno-veno ECMO has been reported for the emergent treatment of carbon monoxide intoxication. If emergency physicians are treating such a patient and cannot administer hyperbaric oxygen therapy, ECMO represents a valuable alternative that is not commonly thought of in this situation before.
Pathways From Sexual Stigma to Inconsistent Condom Use and Condom Breakage and Slippage Among MSM in Jamaica
Authors: Logie Carmen H. , Wang Ying , Marcus Natania L. , Levermore Kandasi , Jones Nicolette , Ellis Tyrone , Marshall Annecka , Newman Peter A.
Published: April 2018

Background:

HIV prevalence among men who have sex with men (MSM) in Jamaica, where same sex practices are criminalized, is among the Caribbean's highest. Sexual stigma, the devaluation, mistreatment, and reduced power afforded to sexual minorities, is a distal driver of HIV vulnerabilities. The mechanisms accounting for associations between sexual stigma and condom use outcomes are underexplored. We examined pathways from sexual stigma to condom use and condom breakage and/or slippage among MSM in Jamaica.

Methods:

We conducted a cross-sectional survey with a chain-referral sample of MSM (n = 556) in Kingston, Montego Bay, and Ocho Rios. Structural equation modeling using weighted least squares estimation methods was conducted to test the direct effects of sexual stigma on inconsistent condom use and condom breakage/slippage, and the indirect effects through depression, sexual abuse history, and condom use self-efficacy, adjusting for sociodemographic factors.

Results:

One-fifth of participants (21%; 90/422) who had engaged in anal sex reported inconsistent condom use, and 38% (155/410) reported condom breakage/slippage during the previous 4 weeks. The relationship between sexual stigma and inconsistent condom use was mediated by the combination effect of sexual abuse history, condom use self-efficacy, and depression. The relationship between sexual stigma and condom breakage and slippage was mediated by the combination effect of condom use self-efficacy and sexual abuse history.

Conclusions:

Sexual stigma is associated with negative condom use outcomes in Jamaican MSM, mediated by psychosocial factors. Multilevel social ecological approaches to the HIV prevention cascade can inform interventions at individual, interpersonal, community, and systemic levels.
Effects of the Tailored Activity Program in Brazil (TAP-BR) for Persons With Dementia
Authors: Novelli Marcia M.P.C. , Machado Styfany C.B. , Lima Gabriela B. , Cantatore Lais , Sena Barbara P. , Rodrigues Renata S. , Rodrigues Camila I.B. , Canon Mariana B.F. , Piersol Catherine V. , Nitrini Ricardo , Yassuda Monica S. , Gitlin Laura N.
Published: April 2018

Objectives:

The objectives of this study were to evaluate the effects of the Tailored Activity Program—Brazilian version (TAP-BR), on behavioral symptoms and the quality of life (QOL) in persons with dementia, as well as on their caregivers, and on caregiver burden.

Materials and Methods:

A 2-group randomized controlled trial with 30 dyads was conducted: the experimental group (n=15) received TAP-BR over 4 months, and a wait-list control group (n=15) received usual care. Dyads were recruited from the community of Santos City, Brazil.

Results:

For persons with dementia, 50% were female individuals, the average age was 81.37 (±7.57), and the educational level was 9.97 (±5.32) years. For caregivers, 83.33% were female, the average age was 65.97 (±10.13), and the educational level was 12.10 (±4.44) years. At posttest, in comparison with the wait-list control group, experimental group caregivers reported greater reductions in number (P<0.001; Cohen d=0.93), frequency (P<0.001; Cohen d=1.12), and intensity (P<0.001; Cohen d=0.77) of the behavioral psychological symptoms of dementia, and caregiver distress (P<0.001; Cohen d=0.87). Caregivers also reported improvement in their own QOL (P<0.05; Cohen d=0.57) and that of the person with dementia (P<0.01; Cohen d=0.56); no differences were found in the ratings of QOL by the person with dementia themselves.

Conclusions:

The results provide compelling evidence that the TAP-BR is an effective strategy to support dementia caregivers in other cultures (cross-validation).
Electrostatic self-cleaning gecko-like adhesives
Authors: Alizadehyazdi Vahid , Modabberifar Mehdi , Mahmoudzadeh Akherat S. M. Javid , Spenko Matthew
Published: April 2018

This paper describes the use of the electrostatic element of an electrostatic/gecko-like adhesive to repel dust particles, which have been shown to significantly affect adhesion and reliability. The result is a non-destructive, non-contact cleaning method that can be used in conjunction with other cleaning techniques, many of which rely on physical contact between the fibrillar adhesive and substrate. The paper focuses on experimental evaluation of the repulsion of 100 μm glass beads as a function of wave shape, frequency, phase number and electrode direction in relation to the gecko-like features. Results show that a two-phase square wave with the lowest practically feasible frequency can remove 100 μm glass beads from a directional gecko-like adhesive with up to 70% efficiency. Finally, using the optimized electrostatic cleaning properties, results show an approximately 25% recovery in shear stress on a rough glass for three contaminated directional gecko-like adhesives after contact with a dusty table.
Alginate foam-based three-dimensional culture to investigate drug sensitivity in primary leukaemia cells
Authors: Karimpoor Mahroo , Yebra-Fernandez Eva , Parhizkar Maryam , Orlu Mine , Craig Duncan , Khorashad Jamshid S. , Edirisinghe Mohan
Published: April 2018

The development of assays for evaluating the sensitivity of leukaemia cells to anti-cancer agents is becoming an important aspect of personalized medicine. Conventional cell cultures lack the three-dimensional (3D) structure of the bone marrow (BM), the extracellular matrix and stromal components which are crucial for the growth and survival of leukaemia stem cells. To accurately predict the sensitivity of the leukaemia cells in anin vitroassay a culturing system containing the essential components of BM is required. In this study, we developed a porous calcium alginate foam-based scaffold to be used for 3D culture. The new 3D culture was shown to be cell compatible as it supported the proliferation of both normal haematopoietic and leukaemia cells. Our cell differential assay for myeloid markers showed that the porous foam-based 3D culture enhanced myeloid differentiation in both leukaemia and normal haematopoietic cells compared to two-dimensional culture. The foam-based scaffold reduced the sensitivity of the leukaemia cells to the tested antileukaemia agents in K562 and HL60 leukaemia cell line model and also primary myeloid leukaemia cells. This observation supports the application of calcium alginate foams as scaffold components of the 3D cultures for investigation of sensitivity to antileukaemia agents in primary myeloid cells.
Projects and pedagogical expectations: Inside P. J. Marperger's ‘golden clover leaf’ (
Trifolium
), 1700–1730
Authors: Whitmer Kelly J.
Published: April 2018

Many eighteenth-century projectors believed in the potential of pedagogy, including its ability to improve lives and to radically reconfigure the structure of society. Despite an obvious inability to predict how effective their projects would be if implemented, those who managed to gain the support of state leaders very frequently peddled educational reform schemes they expected would generate real improvements, including heightened abilities to apprehend the quality of usefulness. This paper considers the relationship between pedagogy and expectations in a three-part reform project put forward by an early commercial advisor and projector named Paul Jacob Marperger (1656–1730). Keenly aware of the pedagogical dimensions of ongoing efforts to both generate useful knowledge and to cultivate skilled observers and makers of it, Marperger used his project to showcase his commitment to the incremental improvement of society via the creation of new training regimens for young people and adults. The paper studies how he linked his expectations to existing institutions, technologies and ongoing reform efforts, including new teaching methods and materials.
Ultrasound-assisted synthesis of N235-impregnated resins for vanadium (V) adsorption
Authors: Chen Bo , Bao Shenxu , Zhang Yimin , Zheng Ruwei
Published: April 2018

N235-impregnated resins were prepared using XAD-16HP macroporous adsorption resins as support with and without ultrasonic irradiation to evaluate the effects of ultrasound impregnation (UI) on the preparation and adsorption characteristics of the resins. The results show that the impregnation ratio of the solvent-impregnated resins (SIRs) prepared by ultrasound impregnation method (SIRs-UI) increases obviously but their adsorption capacity for V(V) just slightly increases and the utilization rate of the extractant decreases with the augmentation of ultrasound power. This may be caused by the fact that more extractant can enter into the deeper pores of the resins under high ultrasound intensity, but these extractants cannot effectively react with V(V). The impregnation equilibrium time of SIRs-UI can be obviously shortened in comparison to that of the SIRs prepared by conventional impregnation method (SIRs-CI) (3 min versus 240 min) due to the cavitation effect evoked by ultrasound. Ultrasonic irradiation may cause more N235 desorbed from the pores of the resin at low N235 content, resulting in lower adsorption capacity for V(V) than that of SIRs-CI, but the adsorption capacity is inverse at higher N235 content. N235 may be distributed more homogeneously in the pores of XAD-16HP with ultrasonic irradiation, thus, SIRs-UI presents higher adsorption capacity and stronger stability than SIRs-CI. This study manifests that ultrasound-assistant impregnation method may be a potential and promising technique for the preparation of SIRs.
Accelerated degradation of polyetheretherketone and its composites in the deep sea
Authors: Liu Hao , Wang Jianzhang , Jiang Pengfei , Yan Fengyuan
Published: April 2018

The performance of polymer composites in seawater, under high hydrostatic pressure (typically few tens of MPa), for simulating exposures at great depths in seas and oceans, has been little studied. In this paper, polyetheretherketone (PEEK) and its composites reinforced by carbon fibres and glass fibres were prepared. The seawater environment with different seawater hydrostatic pressure ranging from normal pressure to 40 MPa was simulated with special equipment, in which the seawater absorption and wear behaviour of PEEK and PEEK-based composites were examined
in situ
. The effects of seawater hydrostatic pressure on the mechanical properties, wear resistance and microstructure of PEEK and its composites were focused on. The results showed that seawater absorption of PEEK and its composites were greatly accelerated by increased hydrostatic pressure in the deep sea. Affected by seawater absorption, both for neat PEEK and composites, the degradation on mechanical properties, wear resistance and crystallinity were induced, the degree of which was increasingly serious with the increase of hydrostatic pressure of seawater environment. There existed a good correlation in an identical form of exponential function between the wear rate and the seawater hydrostatic pressure. Moreover, the corresponding mechanisms of the effects of deep-sea hydrostatic pressure were also discussed.
Development of an intravascular ultrasound elastography based on a dual-element transducer
Authors: Shih Cho-Chiang , Chen Pei-Yu , Ma Teng , Zhou Qifa , Shung K. Kirk , Huang Chih-Chung
Published: April 2018

The ability to measure the elastic properties of plaques and vessels would be useful in clinical diagnoses, particularly for detecting a vulnerable plaque. This study demonstrates the feasibility of the combination of intravascular ultrasound (IVUS) and acoustic radiation force elasticity imaging for detecting the distribution of stiffness within atherosclerotic arteries
ex vivo
. A dual-frequency IVUS transducer with two elements was used to induce the propagation of the shear wave (by the 8.5 MHz pushing element) which could be simultaneously monitored by the 31 MHz imaging element. The wave-amplitude image and the wave-velocity image were reconstructed by measuring the peak displacement and wave velocity of shear wave propagation, respectively. System performance was verified using gelatin phantoms. The phantom results demonstrate that the stiffness differences of shear modulus of 1.6 kPa can be distinguished through the wave-amplitude and wave-velocity images. The stiffness distributions of the atherosclerotic aorta from a rabbit were obtained, for which the values of peak displacement and the shear wave velocity were 3.7 ± 1.2 µm and 0.38 ± 0.19 m s
−1
for the lipid-rich plaques, and 1.0 ± 0.2 µm and 3.45 ± 0.45 m s
−1
for the arterial walls, respectively. These results indicate that IVUS elasticity imaging can be used to distinguish the elastic properties of plaques and vessels.
Mean field dynamics of some open quantum systems
Authors: Merkli Marco , Rafiyi Alireza
Published: April 2018

We consider a large number
N
of quantum particles coupled via a mean field interaction to another quantum system (reservoir). Our main result is an expansion for the averages of observables, both of the particles and of the reservoir, in inverse powers of

N

. The analysis is based directly on the Dyson series expansion of the propagator. We analyse the dynamics, in the limit

N
→
∞

, of observables of a fixed number
n
of particles, of extensive particle observables and their fluctuations, as well as of reservoir observables. We illustrate our results on the infinite mode Dicke model and on various energy-conserving models.
Functional MRI in the Nile crocodile: a new avenue for evolutionary neurobiology
Authors: Behroozi Mehdi , Billings Brendon K. , Helluy Xavier , Manger Paul R. , Güntürkün Onur , Ströckens Felix
Published: April 2018

Crocodilians are important for understanding the evolutionary history of amniote neural systems as they are the nearest extant relatives of modern birds and share a stem amniote ancestor with mammals. Although the crocodilian brain has been investigated anatomically, functional studies are rare. Here, we employed functional magnetic resonance imaging (fMRI), never tested in poikilotherms, to investigate crocodilian telencephalic sensory processing. JuvenileCrocodylus niloticuswere placed in a 7 T MRI scanner to record blood oxygenation level-dependent (BOLD) signal changes during the presentation of visual and auditory stimuli. Visual stimulation increased BOLD signals in rostral to mid-caudal portions of the dorso-lateral anterior dorsal ventricular ridge (ADVR). Simple auditory stimuli led to signal increase in the rostromedial and caudocentral ADVR. These activation patterns are in line with previously described projection fields of diencephalic sensory fibres. Furthermore, complex auditory stimuli activated additional regions of the caudomedial ADVR. The recruitment of these additional, presumably higher-order, sensory areas reflects observations made in birds and mammals. Our results indicate that structural and functional aspects of sensory processing have been likely conserved during the evolution of sauropsids. In addition, our study shows that fMRI can be used to investigate neural processing in poikilotherms, providing a new avenue for neurobiological research in these critical species.
Pulmonary ventilation–perfusion mismatch: a novel hypothesis for how diving vertebrates may avoid the bends
Authors: Garcia Párraga Daniel , Moore Michael , Fahlman Andreas
Published: April 2018

Hydrostatic lung compression in diving marine mammals, with collapsing alveoli blocking gas exchange at depth, has been the main theoretical basis for limiting N2uptake and avoiding gas emboli (GE) as they ascend. However, studies of beached and bycaught cetaceans and sea turtles imply that air-breathing marine vertebrates may, under unusual circumstances, develop GE that result in decompression sickness (DCS) symptoms. Theoretical modelling of tissue and blood gas dynamics of breath-hold divers suggests that changes in perfusion and blood flow distribution may also play a significant role. The results from the modelling work suggest that our current understanding of diving physiology in many species is poor, as the models predict blood and tissue N2levels that would result in severe DCS symptoms (chokes, paralysis and death) in a large fraction of natural dive profiles. In this review, we combine published results from marine mammals and turtles to propose alternative mechanisms for how marine vertebrates control gas exchange in the lung, through management of the pulmonary distribution of alveolar ventilation () and cardiac output/lung perfusion (), varying the level ofin different regions of the lung. Man-made disturbances, causing stress, could alter themismatch level in the lung, resulting in an abnormally elevated uptake of N2, increasing the risk for GE. Our hypothesis provides avenues for new areas of research, offers an explanation for how sonar exposure may alter physiology causing GE and provides a new mechanism for how air-breathing marine vertebrates usually avoid the diving-related problems observed in human divers.