bluuebunny/crossref_metadata_2025 huggingface dataset:
Heart Rate Variability Reflects Similar Cardiac Autonomic Function in Explosive and Aerobically Trained Athletes
Authors: Claiborne Alex , Alessio Helaine , Slattery Eric , Hughes Michael , Barth Edwin , Cox Ronald
Published: October 2021

Autonomic cardiac function can be indirectly detected non-invasively by measuring the variation in microtiming of heart beats by a method known as heart rate variability (HRV). Aerobic training for sport is associated with reduced risk for some factors associated with cardiovascular diseases (CVD), but effects on autonomic function in different athlete types are less known. To compare cardiac autonomic modulation using a standard protocol and established CVD risk factors in highly trained intercollegiate athletes competing in aerobic, explosive, and cross-trained sports. A total of 176 college athletes were categorized in distinct sports as explosive (EA), aerobic (AA), or cross-trained (mixed) athletes. Eight different HRV measures obtained at rest were compared across training type and five health factors: systolic (SBP), diastolic blood pressure (DBP), body weight (BW), sex, and race. All athletic types shared favorable HRV measures that correlated with low CVD risk factors and indicated normal sympathovagal balance. A significant correlation was reported between DBP and pNN50 (% RR intervals > 50 ms) (β = −0.214, p = 0.011) and between BW and low-frequency (LF) power (β = 0.205, p = 0.006). Caucasian and African American athletes differed significantly (p < 0.05) with respect to four HRV variables: pNN50, HF power, LF power, and LF/HF ratios. Explosive, aerobic and mixed athletes had similar cardiovascular and autonomic HRV results in all eight HRV parameters measured. All athletes reported LF and pNN50 values that were significantly correlated with two CVD risk factors: DBP and BW. Compared with Caucasian teammates, African American athletes demonstrated lower LF/HF and higher pNN50, indicating an even more favorable resting sympathovagal activity and healthy CV function.
Issues in the Implementation of Directive 2013/35/EU Regarding the Protection of Workers against Electromagnetic Fields
Authors: Contessa Gian Marco , D’Agostino Simona , Falsaperla Rosaria , Grandi Carlo , Polichetti Alessandro
Published: October 2021

In 2016 the Directive 2013/35/EU regarding the protection of health and safety of workers exposed to electromagnetic fields was transposed in Italy. Since then, the authors of this paper have been faced with several issues related to the implementation of the provisions of the Directive, which pose some interpretative and operative concerns. A primary critical feature of the Directive is that, in some circumstances, conditions of “overexposure”, i.e., of exceeding the exposure limits, are allowed. In the case of transient effects, the “flexibility” concerning the compliance with exposure limits is based on the approach introduced by ICNIRP in its guidelines on static magnetic fields and on time-varying electric and magnetic fields. On the contrary, the possibility of exceeding the exposure limits for health effects, formally recognized in the article of the Directive dealing with derogations, is not included in the ICNIRP guidelines. This paper analyzes the main concerns in interpreting and managing some provisions of the Directive with particular reference to the issue of how the employer can manage the situations of overexposure.
Are Sleep Problems Related to Psychological Distress in Healthy Aging during the COVID-19 Pandemic? A Review
Authors: Cipriani Giuseppina Elena , Bartoli Massimo , Amanzio Martina
Published: October 2021

The SARS-CoV-2 pandemic, characterized by home confinement and other restrictive measures to reduce the spread of the infection, led to significant changes in people’s habits and lifestyle. One of the most common problems is the worsening of sleep quality or quantity, which could have negative effects on psychological wellbeing, particularly in older adults. The purposes of the present literature review considering healthy aging subjects are (a) to examine the existing research on sleep alterations during the current pandemic and (b) to highlight possible relationships between sleep problems and psychological distress. A systematic search strategy was implemented according to PRISMA guidelines in the international literature online databases, up to 1 July 2021. After identification and screening phases, 11 articles were included in this review. The studies found possible associations between sleep problems and mood changes—particularly in terms of depression and anxiety. In addition, altered sleep patterns seemed to be related to changes in individual aspects, lifestyle, and attitudes adopted by older adults during the COVID-19 lockdown. Thus, the pandemic could affect the sleep and psychological wellbeing of the older population, even in healthy aging.
School–Family Relations: An Educational Challenge in Times of COVID-19
Authors: Ferreras-Listán Mario , Hunt-Gómez Coral I. , Moreno-Crespo Pilar , Moreno-Fernández Olga
Published: October 2021

The COVID-19 pandemic has widened the gap regarding access to educational opportunities, which was included in the Millennium Development Goals (MDGs). This descriptive, quantitative study aims to examine the communication strategies employed by secondary schools in Spain during the lockdown, as well as to analyse the co-responsibility of the educational process between schools and families. An ad hoc questionnaire (GIESBAFCOV-19) was designed and implemented to gather information. The results show that, in most cases, mothers were responsible for assisting and supervising their children’s homework as persons in charge of education-related matters. Additionally, before the lockdown was put in place, about half of the participating families received information from the educative centres regarding the disease and sanitary measures. Once the lockdown took place, families put the focus on their children’s schoolwork, not without difficulties in academic and digital literacy. In general, the families were satisfied with the communication established with the educational centres. The present study has raised the necessity to improve communication between centres and families and to reflect on the tools and systems used for its exchange. Consequently, it seems that information and digital competences should be promoted to guarantee an equalitarian education for all.
Effects of Anodal Cerebellar Transcranial Direct Current Stimulation on Movements in Patients with Cerebellar Ataxias: A Systematic Review
Authors: Wang Shu-Mei , Chan Ying-Wa , Tsui Yiu-On , Chu Fong-Yung
Published: October 2021

Cerebellar transcranial direct current stimulation (cerebellar tDCS) is a promising therapy for cerebellar ataxias and has attracted increasing attention from researchers and clinicians. A timely systematic review focusing on randomized sham-controlled trials and repeated measures studies is warranted. This study was to systematically review existing evidence regarding effects of anodal cerebellar tDCS on movements in patients with cerebellar ataxias. The searched databases included Web of Science, MEDLINE, PsycINFO, CINAHL, EMBASE, Cochrane Library, and EBSCOhost. Methodological quality of the selected studies was assessed using the Physiotherapy Evidence Database scale. Five studies with 86 patients were identified. Among these, four studies showed positive effects of anodal cerebellar tDCS. Specifically, anodal cerebellar tDCS decreased disease severity and improved finger dexterity and quality of life in patients, but showed incongruent effects on gait control and balance, which may be due to heterogeneity of research participants and choices of measures. The protocols of anodal cerebellar tDCS that improved movements in patients commonly placed the anode over the whole cerebellum and provided ten 2-mA 20-min stimulation sessions. The results may show preliminary evidence that anodal cerebellar tDCS is beneficial to reducing disease severity and improving finger dexterity and quality of life in patients, which lays the groundwork for future studies further examining responses in the cerebello-thalamo-cortical pathway. An increase in sample size, the use of homogeneous patient groups, exploration of the optimal stimulation protocol, and investigation of detailed neural mechanisms are clearly needed in future studies.
Construct Validity and Reliability of a New Basketball Multidirectional Reactive Repeated Sprint Test
Authors: Brini Seifeddine , Boullosa Daniel , Calleja-González Julio , Delextrat Anne
Published: October 2021

The objective of this study was to investigate the construct validity and reliability of a new reactive multidirectional repeated sprinting test (RRSA5COD) in basketball players. Forty male basketball players were divided into two groups: Professional (PRO; n = 20) and Semi-professional (SEMI; n = 20). Participants completed the yo-yo intermittent recovery test level 1 (Yo-YoIR1), the squat jump (SJ), the counter movement jump (CMJ), the single leg drop jump (DJ), the 20-m sprint test, the planed multidirectional repeated sprinting test (PRSA5COD), and the RRSA5COD test. Reaction time (RT) and movement time (MT), total time (TT), best time (BT), and fatigue index (FI) were assessed. Heart rate (HR) was continuously recorded, while rating of perceived exertion (RPE) and blood lactate concentration (LA) were measured post-tests. The reliability of the RRSA5COD test was also assessed between two attempts with one week between them. The RRSA5COD results demonstrated to be reliable with most of the variables showing ICC > 0.80. BA Bonferroni post hoc revealed a significant better TT in favor of RRSA5COD (p < 0.001; ES = 0.15; small), and in favor of PRO (p < 0.001; ES = 0.006; small). The result showed a significant better performance in favor of PRO in all physical fitness tests. In conclusion, it was found that the RRSA5COD discriminates between professional and semi-professional male basketball players, and the results were demonstrated to be reliable.
The Effect of Quantitative Easing through Google Metrics on US Stock Indices
Authors: Poutachidou Nikoletta , Papadamou Stephanos
Published: October 2021

The purpose of this study is to investigate the fluctuations that occur in stock returns of US stock indices when there is an increase in the volume of Google internet searches for the phrase “quantitative easing” in the US. The exponential generalized autoregressive conditional heteroscedasticity model (EGARCH) was applied based on weekly data of stock indices using the three-factor model of Fama and French for the period of 1 January 2006 to 30 October 2020. The existence of a statistically significant relationship between searches and financial variables, especially in the stock market, is evident. The result is strong in three of the four stock indices studied. Specifically, the SVI index was statistically significant, with a positive trend for the S&P 500 and Dow Jones indices and a negative trend for the VIX index. Investor focus on quantitative easing (QE), as determined by Google metrics, seems to calm stock market volatility and increase stock returns. Although there is a large body of research using Google Trends as a crowdsourcing method of forecasting stock returns, this paper is the first to examine the relationship between the increase in internet searches of “quantitative easing” and stock market returns.
Chronic Exposure to HIV-Derived Protein Tat Impairs Endothelial Function via Indirect Alteration in Fat Mass and Nox1-Mediated Mechanisms in Mice
Authors: Kovacs Laszlo , Bruder-Nascimento Thiago , Greene Lindsey , Kennard Simone , Belin de Chantemèle Eric J.
Published: October 2021

People living with human immunodeficiency virus (HIV) (PLWH) have increased risk for atherosclerosis-related cardiovascular disease (CVD), the main cause of death in this population. Notwithstanding, the mechanisms of HIV-associated vascular pathogenesis are not fully elucidated. Therefore, we sought to determine whether HIV-regulatory protein Tat mediates HIV-induced endothelial dysfunction via NADPH oxidase 1 (Nox1)-dependent mechanisms. Body weight, fat mass, leptin levels, expression of reactive oxygen species (ROS)-producing enzymes and vascular function were assessed in C57BL/6 male mice treated with Tat for 3 days and 4 weeks. Aortic rings and human endothelial cells were also treated with Tat for 2–24 h in ex vivo and in vitro settings. Chronic (4 weeks) but not acute (3 days and 2–24 h) treatment with Tat decreased body weight, fat mass, and leptin levels and increased the expression of Nox1 and its coactivator NADPH oxidase Activator 1 (NoxA1). This was associated with impaired endothelium-dependent vasorelaxation. Importantly, specific inhibition of Nox1 with GKT771 and chronic leptin infusion restored endothelial function in Tat-treated mice. These data rule out direct effects of HIV-Tat on endothelial function and imply the contribution of reductions in adipose mass and leptin production which likely explain upregulated expression of Nox1 and NoxA1. The Nox1 and leptin system may provide potential targets to improve vascular function in HIV infection-associated CVD.
Late Inflammation Induced by Asbestiform Fibers in Mice Is Ameliorated by a Small Molecule Synthetic Lignan
Authors: Badger Reagan , Park Kyewon , Pietrofesa Ralph A. , Christofidou-Solomidou Melpo , Serve Kinta M.
Published: October 2021

Exposure to Libby amphibole (LA) asbestos-like fibers is associated with increased risk of asbestosis, mesothelioma, pulmonary disease, and systemic autoimmune disease. LGM2605 is a small molecule antioxidant and free radical scavenger, with anti-inflammatory effects in various disease models. The current study aimed to determine whether the protective effects of LGM2605 persist during the late inflammatory phase post-LA exposure. Male and female C57BL/6 mice were administered daily LGM2605 (100 mg/kg) via gel cups for 3 days before and 14 days after a 200 µg LA given via intraperitoneal (i.p.) injection. Control mice were given unsupplemented gel cups and an equivalent dose of i.p. saline. On day 14 post-LA treatment, peritoneal lavage was assessed for immune cell influx, cytokine concentrations, oxidative stress biomarkers, and immunoglobulins. During the late inflammatory phase post-LA exposure, we noted an alteration in trafficking of both innate and adaptive immune cells, increased pro-inflammatory cytokine concentrations, induction of immunoglobulin isotype switching, and increased oxidized guanine species. LGM2605 countered these changes similarly among male and female mice, ameliorating late inflammation and altering immune responses in late post-LA exposure. These data support possible efficacy of LGM2605 in the prolonged treatment of LA-associated disease and other inflammatory conditions.
Reactive Oxygen Species Mediate 6c-Induced Mitochondrial and Lysosomal Dysfunction, Autophagic Cell Death, and DNA Damage in Hepatocellular Carcinoma
Authors: Wang Senzhen , Xu Xiaojuan , Che Delu , Fan Ronghui , Gao Mengke , Cao Yue , Ge Chaochao , Feng Yongli , Li Jinghua , Xie Songqiang , Wang Chaojie , Dai Fujun , Gao Lei , Wang Yuxia
Published: October 2021

Increasing the level of reactive oxygen species (ROS) in cancer cells has been suggested as a viable approach to cancer therapy. Our previous study has demonstrated that mitochondria-targeted flavone-naphthalimide-polyamine conjugate 6c elevates the level of ROS in cancer cells. However, the detailed role of ROS in 6c-treated cancer cells is not clearly stated. The biological effects and in-depth mechanisms of 6c in cancer cells need to be further investigated. In this study, we confirmed that mitochondria are the main source of 6c-induced ROS, as demonstrated by an increase in 2′,7′-dichlorodihydrofluorescein diacetate (DCFH-DA) and MitoSox fluorescence. Compound 6c-induced mitochondrial ROS caused mitochondrial dysfunction and lysosomal destabilization confirmed by absolute quantitation (iTRAQ)-based comparative proteomics. Compound 6c-induced metabolic pathway dysfunction and lysosomal destabilization was attenuated by N-acetyl-L-cysteine (NAC). iTRAQ-based comparative proteomics showed that ROS regulated the expression of 6c-mediated proteins, and treatment with 6c promoted the formation of autophagosomes depending on ROS. Compound 6c-induced DNA damage was characterized by comet assay, p53 phosphorylation, and γH2A.X, which was diminished by pretreatment with NAC. Compound 6c-induced cell death was partially reversed by 3-methyladenine (3-MA), bafilomycin (BAF) A1, and NAC, respectively. Taken together, the data obtained in our study highlighted the involvement of mitochondrial ROS in 6c-induced autophagic cell death, mitochondrial and lysosomal dysfunction, and DNA damage.
The Metastatic Capacity of Melanoma Reveals Alternative Pathways of Cancer Dissemination
Authors: Corsini Michela , Ravelli Cosetta , Grillo Elisabetta , Mitola Stefania
Published: October 2021

For many years the growth of solid tumors has been associated with their vascularization. The new vessels are needed to deliver oxygen and nutrients within the tumor mass. At the same time, these poorly stabilized vessels act as “Trojan horses” and open a way out for cancer cells. More recently, tumors have been identified whose growth appears to be independent of endothelial cell activity. Here we describe the ability of cancer cells to differentiate and reorganize themself in channels similar to blood vessels containing blood flow, overcoming the need for the angiogenic process of tumor vascularization. Together with the new vessels arising both from angiogenic and vasculogenic processes, these vessel-like structures can be exploited by tumor cells as a guide for migration and metastatic dissemination. In addition to classical intravascular dissemination, cancer cells can acquire pericytic features, interact with the endothelial basal lamina and migrate toward vessels or outside of the vessels. As expected, these alternative tumor behaviors assume greater importance if we consider that drugs with anti-angiogenic action directed against endothelial cells or their ligands are currently used in cancer therapy.
Lymphocyte-to-Monocyte Ratio as a Marker for Endoscopic Activity in Ulcerative Colitis
Authors: Ishida Natsuki , Takahashi Satoru , Asai Yusuke , Miyazu Takahiro , Tamura Satoshi , Tani Shinya , Yamade Mihoko , Iwaizumi Moriya , Hamaya Yasushi , Osawa Satoshi , Furuta Takahisa , Sugimoto Ken
Published: October 2021

Leukocyte subtypes can be used to evaluate the severity of ulcerative colitis (UC). In this study, we examined the relationship between the lymphocyte-to-monocyte ratio (LMR) and the Mayo endoscopic score (MES) in assessing endoscopic activity in UC. Eighty-nine samples of leukocyte subtypes and biomarkers, including fecal calprotectin (FC), the fecal immunochemical occult blood test (FIT), and C-reactive protein (CRP), from 71 patients with UC were retrospectively investigated, along with the MES. The MES was significantly correlated with the LMR, FC, the FIT, and CRP. There were significant differences in the LMR, FC, the FIT, and CRP between groups with an MES < 1 and >2 (p = 0.001, p = 0.003, p < 0.001, and p < 0.001, respectively). In the receiver operating characteristic (ROC) analysis for predicting mucosal healing (MES 0 or 1), the areas under the curve (AUCs) for the LMR, FC, the FIT, and CRP, were 0.712, 0.860, 0.908, and 0.796, respectively. In the analysis of patients without immunomodulators, the correlation of the MES with the LMR and CRP was significant. The LMR can be used to assess endoscopic activity in UC, particularly in patients without immunomodulators.
Case Studies and Challenges of Implementing Geotechnical Building Information Modelling in Malaysia
Authors: Lee Min Lee , Lee Yee Linn , Goh Sxue Liang , Koo Chai Hoon , Lau See Hung , Chong Siaw Yah
Published: October 2021

Unforeseen ground conditions are some of the main contributors to construction cost over-runs and late completion. Recent research trends have witnessed the scopes of building information modeling (BIM) technology being extended to subsoil and substructure constructions, or simply known as geotechnical BIM. This paper aimed to explore the procedures of developing 3D subsoil models through two case studies in Malaysia. The geotechnical BIM processes were performed by commercial software, AutoCAD Civil 3D 2017, with the extension of the Geotechnical Module. The modeling procedures can be divided into three main stages, namely data collection, data interpretation, and data visualization. The subsoil models were successfully developed at different levels of detailing to serve for different applications. The results showed that the 3D subsoil modeling required huge modeling and computational efforts, particularly when dealing with tropical residual soil profiles in Malaysia that are highly intricate. Thus, an adequate soil strata generalization was required to simplify the generated subsoil model. Data collection and management was identified as one of the main challenges of promoting geotechnical BIM in Malaysia at a macro-scale. Despite the challenges, successful implementation of the geotechnical building information in the present case studies were proved to be capable of promoting interoperability of soil data, which is an essential element in sustainable construction.
Design of a Research Laboratory Drive System for a Synchronous Reluctance Motor for Vector Control and Performance Analysis
Authors: Heidari Hamidreza , Rassõlkin Anton , Kallaste Ants , Vaimann Toomas , Andriushchenko Ekaterina , Belahcen Anouar
Published: October 2021

Motor-drive systems have the most significant share in industrial energy consumption, which requires a deep study in every aspect of the field. This paper presents a synchronous reluctance motor (SynRM) drive system based on Plecs RT box 1. The system’s design provides the opportunity for the open-loop and closed-loop control of the motor and a characteristic performance analysis of the motor. This paper focuses on the hardware implementation of a research laboratory setup and the precise vector control of the SynRM in real-time. The application of the digital controller and inverter to drive SynRM is examined. The voltage, current, and speed transducers were employed for monitoring the protective measures and to control the motor in the closed-loop. The design of the signal conditioning and the intermediary cards for isolation and data acquisition are described in detail. An algorithm is proposed to measure the whole system parameters, including motor, inverter, and cables. Thanks to the RT box 1, the principle of real-time simulation of control algorithms is investigated, and the rapid control prototyping of field-oriented control (FOC) of SynRM was implemented. The simulation of the system was carried out in the Plecs platform, and the results are presented. The experimental results of the implemented control algorithms validate the setup’s performance and the control algorithm. Finally, as a study of the motor’s performance, the efficiency map of the motor is drawn in different speed and torque ranges.
Composites Composed of Hydrophilic and Hydrophobic Polymers, and Hydroxyapatite Nanoparticles: Synthesis, Characterization, and Study of Their Biocompatible Properties
Authors: Gordienko Mariia , Karakatenko Elena , Menshutina Natalia , Koroleva Marina , Gilmutdinova Ilmira , Eremin Petr
Published: October 2021

The creation of artificial biocomposites consisting of biocompatible materials in combination with bioactive molecules is one of the main tasks of tissue engineering. The development of new materials, which are biocompatible, functional, and also biodegradable in vivo, is a specific problem. Two types of products can be formed from these materials in the processes of biodegradation. The first types of substances are natural for a living organism and are included in the metabolism of cells, for example, sugars, lactic, glycolic, and β-hydroxybutyric acids. Substances that are not metabolized by cells represent the other type. In the latter case, such products should not be toxic, and their concentration when entering the bloodstream should not exceed the established maximum permissible level. The composite materials based on a mixture of biodegradable synthetic and natural polymers with the addition of hydroxyapatite nanoparticles, which acts as a stabilizer of the dispersed system during production of the composite, and which is a biologically active component of the resulting matrix, were obtained and studied. The indirect effect of the shape, size, and surface charge of hydroxyapatite nanoparticles on the structure and porosity of the formed matrix was shown. An in vivo study showed the absence of acute toxicity of the developed composites.
Preparation and Characterization of Moldable Demineralized Bone Matrix/Calcium Sulfate Composite Bone Graft Materials
Authors: Chen I-Cheng , Su Chen-Ying , Lai Chun-Cheih , Tsou Yi-Syue , Zheng Yudong , Fang Hsu-Wei
Published: October 2021

Demineralized bone matrix (DBM) is a decalcified allo/xenograft retaining collagen and noncollagenous proteins, which has been extensively used because of its osteoconductive and osteoinductive properties. Calcium sulfate (CaSO4, CS) is a synthetic bone substitute used in bone healing with biocompatible, nontoxic, bioabsorbable, osteoconductive, and good mechanical characteristics. This study aims to prepare a DBM/CS composite bone graft material in a moldable putty form without compromising the peculiar properties of DBM and CS. For this purpose, firstly, porcine femur was defatted using chloroform/methanol and extracted by acid for demineralization, then freeze-dried and milled/sieved to obtain DBM powder. Secondly, the α-form and β-form of calcium sulfate hemihydrate (CaSO4·0.5H2O, CSH) were produced by heating gypsum (CaSO4·2H2O). The morphology and particle sizes of α- and β-CSH were obtained by SEM, and their chemical properties were confirmed by EDS, FTIR and XRD. Furthermore, the DBM-based graft was mixed with α- or β-CSH at a ratio of 9:1, and glycerol/4% HPMC was added as a carrier to produce a putty. DBM/CSH putty possesses a low washout rate, good mechanical strength and biocompatibility. In conclusion, we believe that the moldable DBM/CSH composite putty developed in this study could be a promising substitute for the currently available bone grafts, and might have practical application in the orthopedics field as a potential bone void filler.
Nuclear Data Sensitivity Study for the EBR-II Fast Reactor Benchmark Using SCALE with ENDF/B-VII.1 and ENDF/B-VIII.0
Authors: Bostelmann Friederike , Ilas Germina , Wieselquist William A.
Published: October 2021

The EBR-II benchmark, which was recently included in the International Handbook of Evaluated Reactor Physics Benchmark Experiments, served as a basis for assessing the performance of the SCALE code system for fast reactor analyses. A reference SCALE model was developed based on the benchmark specifications. Great agreement was observed between the eigenvalue calculated with this SCALE model and the benchmark eigenvalue. To identify potential gaps and uncertainties of nuclear data for the simulation of various quantities of interest in fast spectrum systems, sensitivity and uncertainty analyses were performed for the eigenvalue, reactivity effects, and the radial power profile of EBR-II using the two most recent ENDF/B nuclear data library releases. While the nominal results are consistent between the calculations with the different libraries, the uncertainties due to nuclear data vary significantly. The major driver of observed uncertainties is the uncertainty of the 235U (n,γ) reaction. Since the uncertainty of this reaction is significantly reduced in the ENDF/B-VIII.0 library compared to ENDF/B-VII.1, the obtained output uncertainties tend to be smaller in ENDF/B-VIII.0 calculations, although the decrease is partially compensated by increased uncertainties in 235U fission and ν¯.
Associations of Stress and Appetite Hormones with Binge Eating in Females with Anorexia Nervosa after Weight Restoration: A Longitudinal Study
Authors: Wu Ya-Ke , Brownley Kimberly A. , Bardone-Cone Anna M. , Bulik Cynthia M. , Baker Jessica H.
Published: October 2021

Binge eating is a transdiagnostic eating disorder symptom that can occur in patients with anorexia nervosa (AN), persisting after weight restoration, and impeding their recovery. However, little is known about the biological predictors of binge eating after AN weight restoration. The goals of this exploratory study of 73 females with AN were: (1) to examine changes in cortisol, the adrenocorticotropic hormone, norepinephrine, ghrelin (total and active), and leptin levels across the admission, discharge, and 3 months post-discharge from the inpatient AN weight restoration; and (2) to determine whether the target hormones were associated with objective or subjective binge eating (OBE or SBE). The participants completed the self-reported Eating Disorder Examination Questionnaire, Beck Anxiety Inventory, and Beck Depression Inventory-II, and provided fasting whole blood samples for hormone assays. The results showed significant changes in body mass index (BMI), cortisol, total ghrelin, and leptin levels over the three time points. The cortisol levels at admission and discharge were significantly associated with the number of SBE episodes at 3 months post-discharge. Findings suggest the need to replicate and confirm the role of cortisol in predicting the emergence of SBE and uncover the mechanisms underlying SBE and cortisol to prevent SBE and its negative consequences.
Do Exercise, Physical Activity, Dietetic, or Combined Interventions Improve Body Weight in New Kidney Transplant Recipients? A Narrative Systematic Review and Meta-Analysis
Authors: Castle Ellen M. , McBride Emily , Greenwood James , Bramham Kate , Chilcot Joseph , Greenwood Sharlene A.
Published: October 2021

Weight gain within the first year of kidney transplantation is associated with adverse outcomes. This narrative systematic review and meta-analysis examines the effect of exercise, physical activity, dietary, and/or combined interventions on body weight and body mass index (BMI) within the first year of kidney transplantation. Seven databases were searched from January 1985 to April 2021 (Prospero ID: CRD42019140865), using a ‘Population, Intervention, Controls, Outcome’ (PICO) framework. The risk-of-bias was assessed by two reviewers. A random-effects meta-analysis was conducted on randomized controlled trials (RCTs) that included post-intervention body weight or BMI values. Of the 1197 articles screened, sixteen met the search criteria. Ten were RCTs, and six were quasi-experimental studies, including a total of 1821 new kidney transplant recipients. The sample sizes ranged from 8 to 452. Interventions (duration and type) were variable. Random-effects meta-analysis revealed no significant difference in post-intervention body weight (−2.5 kg, 95% CI −5.22 to 0.22) or BMI (−0.4 kg/m2, 95% CI −1.33 to 0.54). Despite methodological variance, statistical heterogeneity was not significant. Sensitivity analysis suggests combined interventions warrant further investigation. Five RCTs were classified as ‘high-risk’, one as ‘some-concerns’, and four as ‘low-risk’ for bias. We did not find evidence that dietary, exercise, or combined interventions led to significant changes in body weight or BMI post kidney transplantation. The number and quality of intervention studies are low. Higher quality RCTs are needed to evaluate the immediate and longer-term effects of combined interventions on body weight in new kidney transplant recipients.
Exploring Progress with Supply Chain Risk Management during the First Year of the COVID-19 Pandemic
Authors: van Hoek Remko
Published: October 2021

Background: In response to calls for actionable research that considers ongoing pandemic risk dynamics, we explore how risks experienced and risk mitigation techniques used have changed during the first year of the pandemic. Methods: We used a survey and studied six cases; data were collected both at the start of the pandemic and one year into the pandemic. This paper offers the first empirical exploration of the first full year of the pandemic and provides data points from both early and one year into the pandemic. Results: Our findings indicate that not only are pandemic risks far from mitigated, several types of risks have also increased in severity. Multifaceted and multidirectional approaches have been adopted, going well beyond demand and supply risks (the risks most widely considered in the literature) and much more work remains for supply chain managers to mitigate risks and improve supply chain resilience. Conclusions: We find that in addition to the risk management techniques, considering behavioral aspects is key for navigating a pathway towards risk mitigation.
New Methodologies Indicating Adhesive Wear in Load Step Tests on the Translatory Oscillation Tribometer
Authors: Patzer Gregor , Woydt Mathias
Published: October 2021

When looking in detail at analyses of the tribological load-carrying capacity of lubricants, it becomes apparent that an exclusive evaluation of the evolution of the coefficient of friction alone cannot provide any sufficient criteria for determining the occurrence of adhesive failure. For this reason, extending the knowledge base by combining several criteria in order to draw a clearer picture of adhesive wear mechanisms is urgently required. This can be achieved by combining the evolution of coefficient of friction with stroke signals and/or the electrical contact resistance and/or contact temperature and/or acoustic emission and/or stroke zero position, frictional power input and further derived parameters.
3-[N-(4-Methoxybenzyl)amino]benzo[de]anthracen-7-one
Authors: Kirilova Alise , Pučkins Aleksandrs , Belyakov Sergey , Kirilova Elena
Published: October 2021

Herein, we describe the synthesis of 3-[N-(4-methoxybenzyl)amino]benzo[de]anthracen-7-one via a two-step procedure including 3-aminobenzanthrone condensation with anisaldehyde and following reduction of obtained imine to appropriate amine by sodium borohydride. The structure of the synthesized compounds was established by elemental analysis, nuclear magnetic resonance spectroscopy, mass spectrometry (EI-MS), and infrared spectroscopy (FT-IR) and confirmed by single-crystal X-ray diffraction. The title compound was analyzed by thermal gravimetric analysis, UV/vis, and fluorescence spectroscopy.
Possible Adrenal Involvement in Long COVID Syndrome
Authors: Salzano Ciro , Saracino Giovanna , Cardillo Giuseppe
Published: October 2021

Background: A significant number of patients with COVID-19 experience prolonged symptoms, known as Long COVID. The most frequent symptoms are fatigue and cognitive dysfunction. We describe a patient suffering from Long COVID in whom adrenal involvement was highlighted. Methods: The patient described Long COVID symptoms that persist 3 months after the negativization of the molecular swab test. The main symptoms were weakness, brain fog, dizziness, and muscular and joint pain. All routine lab panels for inflammation, anemia, and thyroid and liver function were conducted. Moreover, salivary cortisol and DHEA-S determinations were used to compute the adrenal stress index (ASI). Results: All tests were negative, except the ASI that showed very low levels of free cortisol. The patient started hydrocortisone acetate supplementation. Conclusion: Long COVID symptoms could be explained by an adrenal involvement, due to a COVID-19 action on adrenal glands and by a iatrogenic side effect of high glucocorticoid therapy during the COVID-19 infection. Salivary cortisol determination is effective for establishing a correct recovery plan.
COVID-19 Infection and Neuropathological Features
Authors: Freire-de-Lima Leonardo , Scovino Aline Miranda , Marques da Fonseca Leonardo , Barreto Menezes Camilla Cristie , Santos Carlos Antonio do Nascimento , Freire de Lima Marco Edilson , Decote-Ricardo Debora , Freire-de-Lima Matheus , da Costa Kelli Monteiro , dos Reis Jhenifer Santos , Rodrigues da Costa Santos Marcos André , Freire-de-Lima Celio Geraldo , Morrot Alexandre
Published: October 2021

The pathology associated with COVID-19 infection is progressively being revealed. Recent postmortem assessments have revealed acute airway inflammation as well as diffuse alveolar damage, which bears resemblance to severe acute respiratory syndromes induced by both SARS-CoV and MERS-CoV infections. Although recent papers have highlighted some neuropathologies associated with COVID-19 infection, little is known about this topic of great importance in the area of public health. Here, we discuss how neuroinflammation related to COVID-19 could be triggered by direct viral neuroinvasion and/or cytokine release over the course of the infection.
Contribution of Metabolomics to the Understanding of NAFLD and NASH Syndromes: A Systematic Review
Authors: Piras Cristina , Noto Antonio , Ibba Luciano , Deidda Martino , Fanos Vassilios , Muntoni Sandro , Leoni Vera Piera , Atzori Luigi
Published: October 2021

Several differential panels of metabolites have been associated with the presence of metabolic syndrome and its related conditions, namely non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH). This study aimed to perform a systematic review to summarize the most recent finding in terms of circulating biomarkers following NAFLD/NASH syndromes. Hence, the research was focused on NAFLD/NASH studies analysed by metabolomics approaches. Following Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines, a systematic search was conducted on the PubMed database. The inclusion criteria were (i) publication date between 2010 and 2021, (ii) presence of the combination of terms: metabolomics and NAFLD/NASH, and (iii) published in a scholarly peer-reviewed journal. Studies were excluded from the review if they were (i) single-case studies, (ii) unpublished thesis and dissertation studies, and (iii) not published in a peer-reviewed journal. Following these procedures, 10 eligible studies among 93 were taken into consideration. The metabolisms of amino acids, fatty acid, and vitamins were significantly different in patients affected by NAFLD and NASH compared to healthy controls. These findings suggest that low weight metabolites are an important indicator for NAFLD/NASH syndrome and there is a strong overlap between NAFLD/NASH and the metabolic syndrome. These findings may lead to new perspectives in early diagnosis, identification of novel biomarkers, and providing novel targets for pharmacological interventions.
Comparison of the Therapeutic Effects of Native and Anionic Nanofibrillar Cellulose Hydrogels for Full-Thickness Skin Wound Healing
Authors: Koivuniemi Raili , Xu Qian , Snirvi Jasmi , Lara-Sáez Irene , Merivaara Arto , Luukko Kari , Nuopponen Markus , Wang Wenxin , Yliperttula Marjo
Published: October 2021

Nanofibrillar cellulose (NFC)-derived dressings such as films, hydrogels, and aerogels are one of the favorable materials for wound healing due to their proper mechanical properties and water holding ability. However, the therapeutic differences between native and anionic NFC materials are rarely studied. In this report, we compared the differences and addressed the regenerative potential of native and anionic wood-derived NFC hydrogels for wound treatment. In vitro characteristics of the hydrogels were detected using scanning electron microscopy, rheological measurements, and swelling and hemolytic activity assays. Skin regeneration at an early stage after hydrogel treatment was analyzed using an in vivo splinted excisional full-thickness skin wound model in C57BL/6 mice. Both native NFC and anionic NFC (ANFC) hydrogel with differing mechanical and surface properties were shown to be biocompatible. Surprisingly, wounds treated with NFC and ANFC hydrogel did not show any statistical difference compared with control wounds and progressed through normal wound closure, inflammatory response, re-epithelialization, vascularization, and tissue maturation with no signs of fibrosis. The data show here for the first time the therapeutic performance of native and anionic NFC hydrogel in a wound mimicking human wound healing mechanisms. The mechanical properties of native and anionic NFC hydrogels such as the capability to modify material stiffness may also prove to be valuable in the management of wounds in the future.
Bioinformatics Analysis Identifies a Small ORF in the Genome of Fish Nidoviruses of Genus Oncotshavirus Predicted to Encode a Novel Integral Protein
Authors: Kibenge Frederick , McKibbon Ashley , Kibenge Molly , Wang Yingwei
Published: October 2021

Genome sequence analysis of Atlantic salmon bafinivirus (ASBV) revealed a small open reading frame (ORF) predicted to encode a Type I membrane protein with an N-terminal cleaved signal sequence (110 aa), likely an envelope (E) protein. Bioinformatic analyses showed that the predicted protein is strikingly similar to the coronavirus E protein in structure. This is the first report to identify a putative E protein ORF in the genome of members of the Oncotshavirus genus (subfamily Piscavirinae, family Tobaniviridae, order Nidovirales) and, if expressed would be the third family (after Coronaviridae and Arteriviridae) within the order to have the E protein as a major structural protein.
A Numerical Model for Tracing Structural Response of Ultra-High Performance Concrete Beams
Authors: Solhmirzaei Roya , Kodur Venkatesh
Published: October 2021

This paper presents a finite element-based numerical model for tracing the behavior of ultra-high performance concrete (UHPC) beams. The model developed in ABAQUS can account for stress–strain response of UHPC and reinforcing bar in both tension and compression, bond between concrete and reinforcing steel, and strain hardening effects in bars and UHPC and can trace the detailed response of UHPC beams in the entire range of loading. This model is validated by comparing predicted response parameters including load-strain, load-deflection, and crack propagation against experimental data governed from tests on UHPC beams with different reinforcement ratios, fiber volume fractions, and loading configurations (shear and flexural loading). The validated model is applied to quantify the contribution of stirrups and concrete to shear strength of beams so as to explore the feasibility of removing shear reinforcement in UHPC beams.
Effects of Side-Chain Engineering with the S Atom in Thieno[3,2-b]thiophene-porphyrin to Obtain Small-Molecule Donor Materials for Organic Solar Cells
Authors: Xie Liuping , Tang Wei , Liu Zhixin , Tang Wencheng , Yuan Zihao , Qin Yinbin , Yan Lei , Zhu Xunjin , Zhu Weiguo , Wang Xingzhu
Published: October 2021

To explore the effect of the introduction of heteroatoms on the properties of porphyrin materials, a new porphyrin-based derivative small-molecule donor named as PorTT-T was designed and synthesized based on alkyl-thieno[3,2-b]thiophene(TT)-substituted porphyrins. The linker bridge and end groups of PorTT-T were the same as those of XLP-II small-molecule donor materials, while the side-chain attached to the core of thieno[3,2-b]thiophene(TT)-substituted porphyrin was different. Measurements of intrinsic properties showed that PorTT-T has wide absorption and appropriate energy levels in the UV-visible range. A comparison of the morphologies of the two materials using atomic force microscopy showed that PorTT-T has a better surface morphology with a smaller root-mean-square roughness, and can present closer intermolecular stacking as compared to XLP-II. The device characterization results showed that PorTT-T with the introduced S atom has a higher open circuit voltage of 0.886 eV, a higher short circuit current of 12.03 mAcm−2, a fill factor of 0.499, a high photovoltaic conversion efficiency of 5.32%, better external quantum efficiency in the UV-visible range, and higher hole mobility.
Greener Is Better: First Approach for the Use of Natural Deep Eutectic Solvents (NADES) to Extract Antioxidants from the Medicinal Halophyte Polygonum maritimum L.
Authors: Rukavina Iva , Rodrigues Maria João , Pereira Catarina G. , Mansinhos Inês , Romano Anabela , Ślusarczyk Sylwester , Matkowski Adam , Custódio Luísa
Published: October 2021

In this study, natural deep eutectic solvents (NADES) formed by choline chloride (ChCl), sucrose, fructose, glucose, and xylose, were used to extract antioxidants from the halophyte Polygonum maritimum L. (sea knotgrass) and compared with conventional solvents (ethanol and acetone). NADES and conventional extracts were made by an ultrasound-assisted procedure and evaluated for in vitro antioxidant properties by the radical scavenging activity (RSA) on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical, oxygen radical absorbance capacity (ORAC), and copper chelating activity (CCA). Samples were profiled by liquid chromatography (LC)-electrospray ionization (ESI)-QTOF-MS analysis. ChCl:fructose was more efficient in the DPPH assay, than the acetone extract. ChCl:sucrose and ChCl:fructose extracts had the highest ORAC when compared with the acetone extract. NADES extracts had higher CCA, than the acetone extract. The phenolic composition of the NADES extracts was less complex than the conventional extracts, but the proportions of major antioxidants, such as flavonols and flavan-3-ols, were similar in all the solvents. Myricitrin was the major flavonoid in all of the samples, while gallic acid was the main phenolic acid in the conventional extracts and present in a greater amount in ChCl:fructose. Results suggest that NADES containing ChCl and sucrose/fructose can replace conventional solvents, especially acetone, in the extraction of antioxidants from sea knotgrass.
Optimization of Infrared Heating Conditions for Precooked Cowpea Production Using Response Surface Methodology
Authors: Ogundele Opeolu M. , Gbashi Sefater , Oyeyinka Samson A. , Kayitesi Eugenie , Adebo Oluwafemi A.
Published: October 2021

The infrared heating of preconditioned cowpea improves its utilization and potential application in food systems. This study investigated the effect of optimizing preconditioning and infrared heating parameters of temperature and time on cooking characteristics of precooked cowpeas using response surface methodology (RSM). The moisture level (32–57%), infrared heating temperature (114–185 °C), and time of processing the seeds (2–18 min) were optimized using a randomized central composite design to achieve optimal characteristics for bulk density and water absorption. A second-order polynomial regression model was fitted to the obtained data, and the fitted model was used to compute the multi-response optimum processing conditions, which were the moisture of 45%, the heating temperature of 185 °C, and time of 5 min. Precooked cowpea seeds from optimized conditions had a 19% increase in pectin solubility. The total phenolic and total flavonoid contents were significantly reduced through complexation of the seeds’ phenolic compounds with other macromolecules but nonetheless exhibited antioxidant properties capable of scavenging free radicals. There was also a significant reduction in phytate and oxalates by 24% and 42%, respectively, which was due to the heat causing the inactivation of these antinutrients. The obtained optimized conditions are adequate in the production of precooked cowpea seeds with improved quality.