bluuebunny/crossref_metadata_2025 huggingface dataset:
Heterogeneous photocatalysis and an anaerobic biological process for leachate treatment
Authors: Becerra Moreno Dorance , Caicedo Cáceres Neldy Yareth , Velásquez Lázaro Claudia Marcela , Machuca Martínez Fiderman , Soto Verjel Joseph Wbeimar
Published: March 2023

The research used a coupling heterogeneous photocatalysis (TiO2-UVsolar) and an anaerobic biological process (Specific Methanogenic Activity Test) to study the treatment of leachate from a landfill in Norte de Santander (Colombia). It developed photocatalysis in a Composite Parabolic Collector (CPC), H2O2 as oxidation assistant, and the combination of different TiO2 levels and pH modeled with a factorial design 32. In the biological test, for a maximum load of 4,500 mg. L-1 of Chemical Oxygen Demand (COD) leachate, 2.0 g. L-1 of Volatile Suspended Solids (VSS) inoculum, and a hydraulic retention time of 23 days, there were no significant COD removal percentages, evidencing the recalcitrant character of these leachates. In the Advanced Oxidation Process (AOP) there was mineralization in terms of DOC of 57%, which evidences the capacity of the process to support the pollutant load of the leachate. The combined process (AOP-Biological) allows additional mineralization in terms of DOC of 21% in the biological process, for a total contribution of the coupling of 78%, which shows the capacity of the AOP to convert toxic wastewater into one with characteristics more suitable for its subsequent degradation in anaerobic biological reactors.
Estudio de nuevos complejos metálicos derivados de un ligando flexible polidentado para aplicaciones biológicas y biomédicas
Authors: Londoño-Mosquera Juan-David , Polo Dorian
Published: March 2023

El presente estudio muestra la obtención de 4 nuevos complejos lantánidos con iones Gd(III), Eu(III), Dy(III) y Yb(III), con dos ligandos polidentados F y L para evaluar su potencial aplicación en el contraste de imágenes para microscopía de fluorescencia (MF), resonancia magnética de imágenes (RMI) y como agentes antibacterianos. Se propone que los complejos poseen una estructura molecular en donde los ligandos quelan al centro metálico a través de los grupos -OH, -N- y -COO-, exhibiendo un aparente número de coordinación de 7. La relajatividad molar r1 muestra que los 4 complejos son capaces de acelerar el tiempo de relajación longitudinal T1 del agua, obteniéndose un r1 de 6.45 mmol-1·L-1·s-1 para el compuesto 1, el cual fue mayor que el valor 2.25 mmol-1·L-1·s-1 para el Dotarem® usado como medicamento de referencia en RMI. Los rendimientos cuánticos en referencia a la fluoresceína fueron menores al 1%, exhibiendo baja eficiencia en los procesos de emisión de radiación visible. Para los complejos se obtuvieron constantes de estabilidad aparente (-log[kap]) entre 21-18, siendo incluso mejores que algunos agentes de contraste. Finalmente, se confirmó que los complejos obtenidos logran unirse a las hebras del ADN a través de un posible mecanismo de intercalación.
Método de distribución de partículas para el colapso homólogo de una esfera
Authors: García Ospina Joe Alejandro , Poveda Tejada Nicanor , Gómez Aponte Juan David , Vera Villamizar Nelson
Published: March 2023

En este trabajo se estudia el colapso adiabático de una esfera autogravitante mediante una simulacióncomputacional realizada con Gadget-2. Este paquete tiene un arquetipo de simulación para el colapsohomólogo de una esfera unidad, la cual se representa mediante una serie de cascarones esféricosconcéntricos, en donde se distribuyen las partículas de manera equidistante para representar una densidadρ ~ r2. Se ha creado otro método basado en considerar la esfera unidad constituida por pequeñas esferasen su interior. El problema se reduce a empaquetar las esferas pequeñas de la mejor manera posible.Este problema ha sido resuelto en física estado sólido. Para la simetría esférica el máximo factor deempaquetamiento lo da una estructura de Bravais tipo FCC. En este trabajo se demuestra que el arquetipo deGadget es equivalente a una estructura CS que tiene un factor de empaquetamiento menor. En consecuencia,la mejor manera de representar una esfera de gas computacionalmente es mediante una distribución FCC.
Wearable Haptic Device as Mobility Aid for Blind People: Electronic Cane - Wearable Device for Mobility of Blind People
Authors: Marques Texeira Caio Henrique , Amorim Rodrigues Amanda , de Azevedo Costa Ana Luiza Fontes , dos Santos Vagner Rogerio
Published: March 2023

The conventional long cane, largely used for mobility of visually impaired people, presents some limitations, such as the short-range detection of obstacles and the inability to protect against head-level obstacles. The purpose of this study was to develop and test a wearable haptic interface system attachable to a long cane in order to detect obstacles and provide notification to the user.
Repercussões das Doenças Inflamatórias Intestinais no Desenvolvimento Socioemocional de Pacientes Pediátricos
Authors: Oliveira Cleicione Rosa de , Alvarenga Patrícia , Paixão Catiele
Published: March 2023

Este estudo descreve as repercussões dos sintomas das doenças inflamatórias intestinais (DII) nas emoções, na vida escolar e nas interações sociais de pacientes pediátricos. Participaram 20 cuidadores de crianças e adolescentes com idades entre cinco e 17 anos e diagnosticados com alguma DII. Os cuidadores, que tinham entre 26 e 54 anos, forneceram informações clínicas e sociodemográficas e responderam a um questionário sobre as repercussões dos sintomas das DII na vida das crianças e dos adolescentes. A análise das frequências absolutas e relativas e o teste de aderência revelaram que os impactos dos sintomas foram significativamente maiores nas emoções quando comparados aos impactos na vida escolar e nas interações sociais (X² = 6,14; df= 2; p= 0,04). O tratamento das DII deve incluir a construção de planos terapêuticos sensíveis às necessidades psicossociais dos pacientes pediátricos.
Associação entre Atividade Física e Aspectos Emocionais de Idosos durante a Pandemia da Covid-19
Authors: Martins Caroline Machado , Soares Vinícius Nagy , Fernandes Paula Teixeira
Published: March 2023

Para conhecer repercussões da pandemia da covid-19, investigamos a associação entre atividade física e aspectos emocionais de idosos. Para isso, 101 pessoas com 60 anos ou mais responderam a um questionário on-line, via Google Forms. Identificamos que 45,5% dos entrevistados pioraram o desempenho físico, enquanto 11% relataram melhora da aptidão física durante a pandemia. Os exercícios físicos mais praticados foram caminhada (54,5%) e musculação (21,8%). Sobre a mobilidade, as atividades mais frequentes foram ir ao mercado (76,2%), caminhar na vizinhança (64,4%) e sair para tomar sol (61,4%). O Modelo Linear Generalizado mostrou que a piora do desempenho físico foi associada aos níveis mais altos de sofrimento emocional (b=4,35; IC 95%: 1,31-7,11; p=0,003). Os nossos resultados indicam que a melhora do desempenho físico gera repercussões positivas sobre aspectos emocionais de idosos, reforçando a importância da prática regular de exercícios físicos, mesmo em um período de pandemia.
Analysis on “Simka Gwae-gwi” in The Context of Tales on Starving Ghosts in the late Chosun Dynasty
Authors:   The Research Of The Korean Classic, Chung Sol-mi
Published: March 2023

This paper aims to explore how the author of Kirichonghwa, Lee Hyun-ki, satirizes the fallen yangban in “Simka Gwae-gwi”. He utilizes a traditional structure of starving ghost stories but adds his own twists and techniques to create a unique work that exposes the absurd attitudes of the yangban. Unlike traditional narratives, Lee places fallen yangban in the role of the ghost and ridicules their behavior and beliefs. He also uses irony to highlight the flawed perception of the yangban towards their own situation. Through his work, Lee criticizes the limits of the fallen nobility by emphasizing their mentality and depicting their poverty as something “fateful” that cannot be avoided.
Furthurmore, what distinguishes “Simka Gwae-gwi” from other works in Kirichonghwa is its unique approach to depicting the fallen yangban. Lee Hyun-ki creates many protagonists that exhibit the typical characteristics of the fallen yangban class, but unlike other works that offer a clear contrast with the middle and lower classes who adapt to the changing realities of the times, “Simka Gwae-gwi” only focuses on the mentality of the yangban by depicting transcendent beings. At the same time, their poverty is depicted as “unavoidable” that only deepens their distress, further emphasizing the limits of their situation.
To sum up, Lee Hyun-ki's use of satire, irony, and transcendent beings offers a critical perspective on the limits of the fallen yangban’s mentality and their poverty. This technique is often found in modern and even contemporary novels, and through this, we can see that Lee sought innovation in his perception and writing style from the traditional ones.
PERAN CSR PRODUK KOSMETIK TERHADAP LOYALITAS PELANGGAN KOTA BATAM
Authors: - Ardila , Renny Christiarini
Published: March 2023

This study aims to analyze the factors that influence customer loyalty in the use of cosmetic products. Data were collected through the distribution of online questionnaires through Google Forms with 430 respondents. The population of this research is people in Batam City who have used cosmetic products from brands that have CSR such as The Body Shop, L'Oreal, Estee Lauder, Kiehl's, Garnier, Innisfree, Wardah, Emina, Somethinc, Avoskin, Sensatia Botanicals, and BLP Beauty. This study utilizes a sampling technique with non-probability sampling and purposive sampling. The collected data will be processed using the Partial Least Squares research method. The study results are that customer satisfaction, customer trust, perceived product quality, perceived service quality, perceived cost, corporate social responsibility, and customer engagement all influence customer behavior in terms of loyalty.
KEBERLANGSUNGAN USAHA UMKM BERDASARKAN MANAJEMEN RISIKO KEUANGAN DI DAERAH LAHAN BASAH KOTA BANJARMASIN
Authors: Jikrillah Sufi , Ziyad Muhammad , Stiadi Doni
Published: March 2023

Abstract
The purpose of this research is to identify the process of financial risk management, to assess the financial risks that may arise and to analyze the strategies that will be carried out by MSMEs in dealing with or managing these financial risks. This research was conducted in accordance with the risk management process (ISO 31000:2018), namely financial risk identification, financial risk analysis, financial risk evaluation and financial risk treatment.
In this study, using Census Sampling, which is a sampling method when all members of the population are used as samples. The number of population and sample is the same (saturated sample) from this study are MSME business actors around the coast of the Martapura river in Banjarmasin City. The number of samples used in this study were 50 MSMEs located on the coast of the Martapura river in Banjarmasin City.
The results of the risk analysis show that there is capital risk, and liquidity risk is included in the categoryUnacceptable (red)that is Financial risk treatment must be carried out immediately even though the costs are high because it involves the continuity of the company so that capital risk and liquidity risk become the main focus and also because these financial risks have a major impact on MSMEs. Market risk and credit risk fall into the categoryUnacceptable (red) then risk treatment needs to be done so that the financial risk is minimized.
Keywords:  Finance Risk Management, SWOT Analysis, SMEs.
ABSTRAK
Tujuan dari penelitian ini adalah mengidentifikasi proses manajemen risiko keuangan, melakukan penilaian terhadap risiko keuangan yang kemungkinan muncul dan melakukan analisa terhadap strategi yang akan dilakukan oleh UMKM dalam menangani ataupun mengelola risiko keuangan tersebut. Penelitian ini dilakukan sesuai dengan proses manajemen risiko (ISO 31000:2018) yaitu identifikasi risiko keuangan, analisis risiko keuangan, evaluasi risiko keuangan dan perlakuan risiko keuangan.
Pada penelitian ini menggunakan Sampling Sensus yaitu metode penarikan sampel bila semua anggota populasi dijadikan sebagai sampel. Jumlah populasi dan sampel adalah sama (sampel jenuh) dari penelitian ini adalah  pelaku usaha UMKM sekitar pesisir sungai Martapura di Kota Banjarmasin. Jumlah sampel yang digunakan dalam penelitian ini adalah sebanyak 50 UMKM yang berada di pesisir sungai Martapura di Kota Banjarmasin.
Hasil analisis risiko terdapat risiko permodalan,  dan risiko likuiditas termasuk dalam kategori Unacceptable (merah) yaitu perlakuan risiko keuangan harus segera dilakukan walaupun biaya mahal karena menyangkut kelangsungan perusahaan sehinga risiko permodalan dan risiko likuiditas menjadi fokus utama  dan juga dikarenakan risiko keuangan tersebut berdampak besar pada UMKM. Risiko pasar dan risiko kredit masuk dalam kategori Unacceptable (merah)  maka perlakuan risiko perlu dilakukan agar risiko keuangan tersebut menjadi minimal.
Kata Kunci : Manajemen Risiko Keuangan, Analisis SWOT, UMKM
PENGARUH LIVE STREAMING SHOPPING TERHADAP PENJUALAN BARANG THRIFSHOP DI KOTA BATAM
Authors: Hulu Yohana Juwitasari , Christiarini Renny
Published: March 2023

This research is based on the phenomenon of selling goods with live broadcasts on social media since the Covid-19 pandemic to know several factors that influence purchase intentions on live streaming shopping on the sale of used goods in Batam City. The study was conducted by collecting 330 samples obtained by distributing questionnaires to people who had watched live broadcasts of used clothes on social media. The data is processed using Smart PLS version 26. The results of this study indicate that Social Interaction does not affect Purchase Intention, followed by Social Interaction which affects Trust. Consumer involvement has a significant effect on trust, followed by perceived economic benefits which have a significant effect on trust, subjective norms and perceived prices have a significant effect on purchase intention. Meanwhile, Subjective Norm does not affect Purchase Intention. For the moderating effect, trust has a significant effect on purchase intention. Through this research, it is hoped that it can provide a view to the public that selling through live broadcasts is the best marketing system
The role of integrated marketing communication, ecological knowledge and co-creation of value toward visitor satisfaction in the hotel industry
Authors: Hadi Antonius Satria
Published: March 2023

This research aims to examine the effect of integrated marketing communication on visitor satisfaction mediated by ecological knowledge and co-creation of value. Respondents in this study were 150 tourists who have stayed at hotels in Yogyakarta. This research has five hypotheses. The analytical technique used in this research were confirmatory factor analysis (CFA) and structural equation model (SEM) using SmartPLS 3 software. The results of this research empirically prove that integrated marketing communication positively affects visitor satisfaction mediated by ecological knowledge and co-creation of value. Each of the hypotheses was accepted and discussed in detail in this article.
A Framework Proposal for the Ex-post Evaluation of a Solution-Driven Pes Scheme. The Case of Medvednica Nature Park
Authors: Bruzzese Stefano , Mandić Iva Tolić , Tisma Sanja , Blanc Simone , Brun Filippo , Vuletić Dijana
Published: March 2023

Payments for Ecosystem Services are a voluntary market-based instrument to remunerate provider(s) of ecosystem services by those who benefit from them. Our research aimed to create an ex-post evaluation framework to identify bottlenecks and elements hindering the success of a solution-driven PES scheme. The framework was applied to a case study to test its feasibility and concerns the provision of health and recreational services in the Medvednica Nature Park (Zagreb, Croatia). The framework was set up through three main sources: the study of PES implementation project documentation, semi-structured interviews with visitors and key stakeholders and web-scraping of TripAdvisor reviews of the park. The main findings confirmed society's interest in the park, but the lack of mapping, quantification, economic valuation and accounting of the services analysed, society's little or no demand to pay for their provision and confused knowledge of the property rights of some ecosystem service providers in the area limit the success of the PES scheme. The framework was useful to describe the chosen PES scheme and to identify bottlenecks and fragilities of the system in place, allowing to correct its application flaws and, on the other hand, to demonstrate its replicability in other contexts.
The financial protection of Indonesian migrant workers and its economic consequences
Authors:   University of North Sumatra, Agusmidah Agusmidah , Wijayanti Asri ,   Muhammadiyah University of Surabaya, Shalihah Fithriatus ,   Ahmad Dahlan University, Lumbangaol Dios Aristo ,   University of North Sumatra, Reinaldo Vatar ,   University of North Sumatra
Published: March 2023

The Indonesian Migrant Worker Placement Service mandates Law Number 18 of 2017, which aims to reduce the departure of illegal and unprotected Indonesian Migrant Workers (IMW). This study aims to describe the problem of job placement and financial protection of Indonesian migrant workers as well as its economic consequences. This study uses a descriptive method with an in-depth case study. The research was conducted in the provinces of Nusa Tenggara Barat (NTB) and Nusa Tenggara Timur (NTT). The research area was chosen because both regions have a bad record in many IMW cases outside Java. The data were obtained using observation and interviews with the authorities in the city/district government agencies. Data analysis using Miles and Huberman is done by data reduction, tabulation, presentation, and conclusion. The results show that the government’s one-stop integrated service (LTSA) has not reached all prospective migrant workers from NTB and NTT. The limitations of LTSA are influenced by technical factors, budget, and insufficient human resources. The research results are expected to provide an overview of the relevant parties always to prevent or suppress illegal IMW, which is the responsibility of the State. So that cases of violence against illegal IMW can be avoided.
Using scoring techniques to assess the landslide events and the level of hazard and socio-economic impact in the Sub-Watershed Samin Upstream of Karanganyar District of Indonesia
Authors:   Slamet Riyadi University, Priyono Priyono , Rahayu Rahayu ,   Slamet Riyadi University, Jumintono Jumintono ,   University Tun Hussein Onn Malaysia, Murwaningtyas Fransiska Sinta Devi ,   Sebelas Maret University, Yatim Hertasning ,   Tompotika Luwuk University, Selamat Asri ,   University Tun Hussein Onn Malaysia
Published: March 2023

Landslide is a type of mass transfer of soil or rock and a mixture of the two to a lower area due to disruption of slope stability, causing economic and environmental damage to property and human life. This study aimed to assess the landslide events and the level of landslide vulnerability and its economic impact using scoring techniques. The scoring is determined by the sum of the weight’s multiplication and the factor that started the landslide. Nine factors causing landslides have been evaluated using the statistical methods. The results showed that the scoring technique could be used as a guideline (tool) to analyze the relationship between landslide events and the level of vulnerability and also assess the socio-economic impact in the Samin Hulu sub-watershed. The survey and mapping results found that the distribution of landslide-prone areas in the Sub-watershed Samin Upstream can be divided into five landslide-prone levels, namely: extraordinarily prone, very prone, prone, somewhat prone, and not prone. The Samin Sub-watershed area can be categorized as an area classified as prone to landslides. To lessen the socio-economic damage to the area, a number of programmes and cooperation initiatives between authorities and local communities have been introduced. For that purpose, a reforestation and agroforestry mechanism is applied which means planting teak forests combined with multiple cropping such as coffee, guava, cashew and other local plants.
Expectativas y Logros ante las prácticas profesionales del estudiante de Pedagogía
Authors: Rodríguez-Gallego Margarita R. , ORDÓÑEZ-SIERRA ROSARIO , Gómez-del-Castillo Segurado María Teresa
Published: March 2023

Este trabajo presenta la experiencia llevada a cabo mediante el uso del blog en la asignatura Prácticas Externas I del Grado en Pedagogía de la Facultad de Ciencias de la Educación de la Universidad de Sevilla. Los objetivos pretenden dar a conocer el trabajo que se ha llevado a cabo en los últimos años sobre el uso del blog como herramienta de comunicación, diálogo y evaluación entre estudiantes y tutores y tutoras académicos; así mismo se da a conocer las expectativas con las que los estudiantes se incorporan a los centros de prácticas, comparándolas con los logros percibidos al finalizar las mismas, así como la evaluación de esta experiencia colaborativa. A través de un estudio longitudinal, los estudiantes expresan observaciones, vivencias y actuaciones que han llevado a cabo y que van describiendo en los post y comentarios semanales realizados en el blog. Los resultados destacan el trabajo colaborativo, el crecimiento profesional y la puesta en práctica de la teoría aprendida. Todos los participantes valoran muy positivamente la dinámica empleada, expresando su intención de continuar con la experiencia en las prácticas de cuarto curso y con la intención de recomendarlo a sus compañeros y compañeras.
Enseñanza-aprendizaje en torno al vino
Authors: Robredo Valgañón Beatriz , Ladrera Rubén , Guadalupe Zenaida , Martínez-Lapuente Leticia , Ayestarán Belén
Published: March 2023

Los derechos culturales, el patrimonio, la diversidad y la creatividad juegan un papel esencial en el éxito de la agenda 2030 porque son componentes centrales del desarrollo humano y sostenible. En este contexto, resulta esencial y prioritaria la formación del alumnado riojano en el mundo vitivinícola, ya que la Comunidad de La Rioja es una referencia internacional en este sector por su gran trascendencia cultural, tradicional, económica y turística. Para realizar esta innovación docente se ha utilizado una metodología de aprendizaje entre iguales con la participación de alumnado de Grado en Enología y de Grado en Educación Primaria, que se encargó de la adecuación didáctica y transferencia del conocimiento en la escuela, mediante talleres relacionados con el vino. Como medida del éxito alcanzado se utilizaron encuestas de satisfacción y un formulario sobre los conocimientos vitivinícolas antes y después de la intervención educativa. La educación entre iguales dentro del contexto universitario ha hecho visibles los conocimientos de cada grado, mejorando así la organización académica en la utilización de recursos humanos y materiales. En concreto, ha permitido mejorar los conocimientos vitivinícolas de los estudiantes, que han valorado satisfactoriamente esta innovación docente, considerándola como un buen método de aprendizaje.
Asymmetry in Return and Volatility Spillovers Between Stock and Bond Markets in Turkey
Authors: KARAKAYA Aykut , KUTLU Melih
Published: March 2023

In this study to analyze the asymmetric volatility spillovers. We study in the stock and bond markets in Borsa Istanbul. The research covers 2003-2019. Financial crises have increased the importance of the transition between the stock and bond market. Apart from the full period, the 2008 financial crisis period examines separately in order to see the effects of the spillovers during the crisis period. First, asymmetric volatility tests with the sign bias test. Then, whether the stock and bond market volatility is asymmetric, investigate with the GJR-GARCH model. Finally, asymmetric volatility between the two markets test with the VARMA-AGARCH model. According to the asymmetric volatility test results, negative volatility asymmetry exists in the bond market in full period. Asymmetric volatility is positive in both market in the crisis time. Return spillovers from the stock market to bond market in full period. It is opposite direction during the crisis period. We have found volatility spillovers bidirectional among the stock market and the bond market. However, during the global crisis period, volatility spillover is bidirectional from the stock market to the bond market.
The Anti-Senescence Effect and Mechanism of 17β-estradiol on Pelvic Organ Prolapse Derived Fibroblasts
Authors: Cheng Juan , Zhao Zhiwei , Wang Ling , Wen Jirui , Miao Yali , Wu Jiang
Published: March 2023

Background:
Recently, low estrogen and the age at menopause as independent risk factors for Pelvic Organ Prolapse (POP) were attracting high attention. In clinical practice, pre-/post-operative Local Estrogen Therapy (LET) shown effectiveness in alleviating POP symptoms. However, there is lack of scientific evidence to support the validity of these claims. Therefore, this study aimed to investigate the anti-senescence effect and mechanism of 17β-estradiol on POP derived fibroblasts.
Methods:
The primary fibroblasts cells were isolated and cultured form surgical POP samples (n = 8, age from 50–75), the passage-0 cells confluence at 80% takes about 15 days and the passage 3–5 cells were used for further test. Immunocytochemistry was used to characterize the primary fibroblasts, CCK8 assay was used to test the cell proliferative capacity and the Senescence-Associated β-Galactosidase (SA-β Gal) Staining was tested to calculate the senescence rate of fibroblasts. Moreover, western blotting was used to detect the expression of COL-I, COL-III, p16INK4A, p21, p-53, SIRT-1 and LC3-I/II protein. In addition, Transmission Electron Microscope (TEM) was used to observe the ultrastructure of fibroblasts.
Results:
The results showed that 17β-estradiol (E2) significantly promoted the POP derived-fibroblasts proliferation and reduced the staining rate of senescence-associated-β-galactosidase (SA-β-Gal), markedly enhanced the extracellular matrix protein COL-I and COL-III accompanied by the inhibition of senescent protein P16INK4a, as well as improved the cells autophagy and metabolic activity. In addition, E2 significantly up-regulated the anti-aging protein SIRT1 and markedly down-regulated p53 and p21, indicating the anti-senescence mechanism of E2 through mediated the Sirt1/p53/p21 axis pathway.
Conclusion:
We provide preliminary evidence that anti-aging effect and mechanism of estrogen on POP fibroblasts, hoping to provide a theoretical basis for estrogen against POP senescence, guide the clinical application and local administration of estrogen on POP treatment, thereby improve long-term maintenance and rejuvenation of the pelvic floor connective tissue.
Validation of an instrument to measure community capacity building for prevention
Authors: Röding Dominik , Birgel Vera , Walter Ulla
Published: March 2023

Aim: In Germany, the CTC-EFF study, a replication study of the U.S. Community Youth Development Study (CYDS), was rolled out in 2021. This article aims to examine the validity of a translated and adapted version of an instrument that measures five constructs of community capacity for prevention.
Subject and Methods: Twenty-two a-priori matched intervention and comparison communities participate in the study. Two to ten community key informants (n = 182) were interviewed for each community. Exploratory (EFA) and confirmatory factor analyses (CFA) were conducted to assess structural validity. Reliability was assessed at the individual level using McDonald’s omega and at the community level using a generalizability coefficient (GC). Inter-rater agreement was measured using an intraclass correlation coefficient (ICC). Concurrent construct validity was assessed using bivariate correlations and mean comparisons.
Results: CFA showed good model fit (CFI = 0.964) for the hypothesized five constructs model. Reliability analyses showed good internal consistency at the individual level (omega = 0.86 – 0.87) and insufficient to moderate reliability at the community level (CG = 0.00 – 0.62). Inter-rater agreement ranged from insufficient to substantial (ICC = 0.02 - 0.32). Consistent with theory, three constructs correlated positively at the individual and community level (r = 0.24 - 0.42). There are no associations between these constructs and interviewer ratings about the respondents’ cooperativeness, trustworthiness, and understanding.
Conclusion: Three of the five constructs were measured with good validity. Two constructs show insufficient reliability. These will be revised until the next CTC-EFF data collection wave. Further validation is indicated.
Trial registration: This study was registered with the German Clinical Trial Register: DRKS00022819 on Aug 18, 2021.
A Note on the Global Asymptotic Stability
Authors: Hejri Mohammad
Published: March 2023

This paper addresses the classical problem of global asymptotic
stability analysis of nonlinear systems. The note followed in this
paper looks at the necessity of an additional condition on the
derivative of the Lyapunov function to achieve the global asymptotic
stability missed in the original statement. The classical theorem
and its proof, selected from some seminal references, are discussed.
It is shown that the available proofs have been developed for a
weaker version of the global asymptotic stability called as
semi-global asymptotic stability by which state convergence is
guaranteed within each compact set of entire space. The new
additional condition extends the existing results to meet the main
definition of global asymptotic stability in which the state
convergence is guaranteed when the initial condition approaches
infinity in the entire space. Numerical results illustrate the
effectiveness of the proposed additional condition.
Direct Gas-Phase Formation of HCOOH through Reaction of Criegee Intermediates with Formaldehyde
Authors: Luo Pei-Ling , Chen I-Yun
Published: March 2023

Ozonolysis of isoprene is considered to be an important source of formic acid (HCOOH), but its underlying reaction mechanisms related to formic acid formation are poorly understood. Here, we report the kinetic and product studies of the reaction between the simplest Criegee intermediate (CH2OO) and formaldehyde (HCHO), both of which are the primary products formed in ozonolysis of isoprene. In addition to evaluation of the temperature and pressure dependencies of the rate coefficients, we determine the branching yields of the products HCOOH + HCHO and CO + H2O + HCHO by simultaneous determination of HCOOH and CO with synchronized two-color time resolved dual-comb spectroscopy. A high yield of HCOOH is obtained up to 40–50% under varied conditions. This work indicates that CH2OO + HCHO would play a critical role to explain high levels of atmospheric HCOOH, particularly in the upper troposphere and lower stratosphere.
Simulation of the heat transfer of a bi-tubular heat exchanger with a hemispherical end
Authors: Imen Dhahri
Published: March 2023

In this study, different heat transfer mechanisms and flow conditions were investigated to determine the temperature distribution. For this purpose, we proposed a coaxial tubular heat exchanger with a hemispherical end for different thermal parameters. Our attention was focused on the effect of geometry on the thermal and dynamic characteristics of the flow and on the performance of the studied heat exchanger. The results obtained show a qualitative agreement between those obtained and those found in the literature with a difference mainly due to the difference in geometry (the hemispherical end of the heat exchanger) and the code used.
4C Mortality Score and CT Severity Score among COVID-19 Patients; A Single Center Prospective Study
Authors: * Azza Farag Said , El-Fateh Ayman Hussein , Esmaeel Tamer El Zaeem , Mady Ahmed Fathy
Published: March 2023

Background

Predictions about the hospital course of the coronavirus disease 2019 (COVID-19) patients are of paramount value.

Objectives

This research was designed to validate 4C mortality and CT severity scores (CT-SS) and detect their relations among patients with covid-19 who are hospitalized as prognostication tools.

Patients and methods

Two hundred and ninety-six confirmed COVID-19 cases were included. They were allocated into 3 groups according to severity;78 in non-severe group, 97 in severe group, and 121 patients in critical group. Patient demographics, clinical characteristics, co-morbidities, lines of treatment, 4C mortality score and CT severity score were assessed upon admission.

Results

The study revealed that 90% and 84.3% sensitivities were observed for both of 4C mortality and CT-SS respectively as predictors of mortality. Significant correlation between both scores (r = 0.6. p = 0.0001) was detected. Multivariate analysis identified 7-fold increased risk of mortality for the patients with 4C mortality score > 9.5 (p = 0.001). CT-SS > 12 (p = 0.02), age ≥ 60, male gender, hypertension and diabetes mellitus were also found as significant independent factors associated with increased mortality.

Conclusion

Satisfactory results were found on addition a verified radiological score to commonly used risk-stratification scores when estimating the probability of death in severe and critical cases in COVID-19.
The association between smoking and the occurrence of hyperuricemia: A retrospective cohort study
Authors: Li Peihua , Li Xinyu , Wang Bing , Li Guosheng , Liu Yudan , Zhao Yuedong , Yu Qing , Gao Zhengnan , Liu Xuhan
Published: March 2023

There is no national or international consensus on the effect of smoking on blood uric acid levels and the risk of hyperuricemia (HUA). By collecting and analyzing clinical data of 3,196 patients with undiagnosed HUA at baseline in Dalian Municipal Central Hospital between January 1, 2010, and January 1, 2021, patients were grouped according to baseline smoking status and smoking index, and Cox regression analysis was applied to the univariate and multifactor analysis of factors that may influence the occurrence of HUA, and further stratified analysis was performed. A total of 485 (15.2%) patients developed HUA. The incidence of HUA was significantly higher in the smoking group than in the nonsmoking group (P<0.05). And there was a statistically significant difference in the incidence of HUA between the smoking index 1-4 groups and the smoking index 0 group (P<0.05). Smoking is an independent risk factor for the occurrence of HUA and is independent of gender, whether a woman is menopausal, BMI, and alcohol consumption. The Smoking index≥601 was an independent risk factor for the occurrence of HUA. However, further prospective studies involving rigorous large samples are needed to further confirm the association between smoking and HUA.
A comparative investigation of variant calling and genotyping for a single non-Caucasian whole genome
Authors: Park HyeonSeul , Gim JungSoo
Published: March 2023

Most genome benchmark studies utilize hg38 as a reference genome (based on Caucasian and African samples) and ‘NA12878’ (a Caucasian sequencing read) for comparison. Here, we aimed to elucidate whether 1) ethnic match or mismatch between the reference genome and sequencing reads produces a distinct result; 2) there is an optimal workflow for single genome data. We assessed the performance of variant calling pipelines using hg38 and a Korean genome (reference genomes) and two whole-genome sequencing (WGS) reads from different ethnic origins: Caucasian (NA12878) and Korean. The pipelines used BWA-mem and Novoalign as mapping tools and GATK4, Strelka2, DeepVariant, and Samtools as variant callers. Using hg38 led to better performance (based on precision and recall), regardless of the ethnic origin of the WGS reads. Novoalign + GATK4 demonstrated best performance when using both WGS data. We assessed pipeline efficiency by removing the markduplicate process, and all pipelines, except Novoalign + DeepVariant, maintained their performance. Novoalign identified more variants overall and in MHC of chr6 when combined with GATK4. No evidence suggested improved variant calling performance from single WGS reads with a different ethnic reference, re-validating hg38 utility. We recommend using Novoalign + GATK4 without markduplication for single PCR-free WGS data.
How to select and understand guidelines for patient-reported outcomes? Scoping review of existing guidelines
Authors: Kaneyasu Takako , Hoshino Eri , Naito Mariko , Suzukamo Yoshimi , Miyazaki Kikuko , Kojima Satomi , Yamaguchi Takuhiro , Kawaguchi Takashi , Miyaji Tempei , Nakajima Takako Eguchi , Shimozuma Kojiro
Published: March 2023

Background
Patient-reported outcomes (PROs), which are health outcomes subjectively provided by patients, have been used in various situations over the past decades as tools to understand patients’ health conditions, and accordingly, numerous PRO questionnaires and guidelines have been developed. In this study, existing PRO guidelines for clinical trials and practice were comprehensively collected to support novice PRO users in academia, industry, clinical practice, regulatory and reimbursement decision-making.
Methods
For the scoping review, we searched databases including MEDLINE, Embase, Google Books, WorldCat, and the National Library of Medicine (NLM) Bookshelf from 2009 to 2020. The inclusion criteria were PRO guidelines for clinical trials/practice and application/utilization, which included quality of life (QOL), PRO, health-related QOL, or health state utilities related to psychometric requirements, collection method and analysis, and clinical interpretation. After the systematic search, three members individually reviewed the data collected, and the reviewed articles and books were scrutinized for the same criteria.
Results
The PRO guidelines published in articles and books between 2009 and 2020 were collected. From the database searches, 1,039 articles and 296 books were selected, of which one book and 25 articles were finally selected. A total of 16 guidelines from articles and books on clinical trials covered issues such as design/reporting, questionnaire preparation, and collection methods, including ePRO, analysis, and clinical interpretation. Five of these covered PRO assessment and application in clinical practice. One PRO guideline was published to inform decision-making such as health technology assessment.
Conclusions
This scoping review classified existing PRO guidelines by stage (evaluation or application), setting (clinical trials/practice), and evaluation process. The classification and summary would facilitate beginners’ judgment in the selection and explanation of terms used in the guidelines would enhance understanding of existing PRO guidelines.
Predicting prognosis and drug sensitivity of ovarian cancer patients using different Programmed cell death patterns
Authors: xia hongmei , Xiao Yu , Ji Liyan , Xu Zelong , Sun Yang
Published: March 2023

Background：Ovarian cancer has a high mortality rate, which has major contributing factors including advanced detection and recurrence susceptibility. For patients with ovarian cancer, optimal predictive models for therapy progression and medication sensitivity are currently lacking. Different types of programmed cell death (PCD) can predict prognosis and medication susceptibility in ovarian cancer and play a significant role in tumor growth.
Materials and methods: By analyzing 12 PCD patterns (apoptosis, necroptosis, ferroptosis, pyroptosis, netotic cell death, entotic cell death, lysosome-dependent cell death, parthanatos, autophagy-dependent cell death, oxeiptosis, and novel regulated cell death by alkaliptosis), Cox multifactorial regression analysis was used to screen a gene set of 20 genes that can each individually affect the prognosis of ovarian cancer. The gene set was then typed and modeled. The model was further validated and additional risk scoring was done. To learn more about the IC50 link between high and low-risk scores and chemotherapeutic drugs, the relationship between high and low-risk scores and the immune microenvironment was examined.
Results: The two examined subtypes of ovarian cancer have different key biological activities, according to the results of typing genes that can independently affect ovarian cancer survival, which combined with clinical characteristics to create a nomogram map with good predictive performance. Additionally, patients with ovarian cancer in the high-risk category were sensitive to Dasatinib, and the type was related to immune checkpoint genes and important tumor microenvironment components.
Conclusion: In short, by combining several cell death patterns, we created a new staging model that can precisely predict the clinical outcome and medication sensitivity of ovarian cancer patients.
Sex-based differences in neck selectivity in total hip arthroplasty using a modular femoral neck system
Authors: Shigemura Tomonori , Murata Yasuaki , Yamamoto Yohei , Kamikawa Koya
Published: March 2023

Background: Dislocation is a major complication of total hip arthroplasty (THA). The modular femoral neck system has some practical advantages in that it permits adjustment neck version and length, if intraoperative instability is present. Anatomical studies have identified morphological differences in the hip joint between men and women. Although sex-based differences exist in hip morphology, it is unclear whether sex-based differences exist in femoral neck selection when the hip is anatomically reconstructed with THA using a modular femoral neck system. This retrospective study aimed to investigate sex-based differences in femoral neck selectivity in THA using a modular neck system.
Hypothesis: We hypothesised that sex-based differences exist in neck selectivity in THA using a modular neck system.
Patients and Methods: Between July 2007 and March 2013, 163 THAs using a modular femoral neck system were performed in 149 patients at Teikyo University Chiba Medical Center. Data on the type of modular neck were retrieved from patient records. Fisher’s exact test was used to investigate sex-based differences in femoral neck selectivity in THA using a modular neck system.
Results: Neck selectivity did not significantly differ between men and women.
Discussion: This retrospective study on THA with a modular femoral neck system revealed no sex-based difference in neck selectivity; however, more than half of the series used varus or version-controlled neck, indicating that a changeable neck may play a role in preventing postoperative dislocation.
Laparoscopic surgery for extremely elderly patients (≥85)-experience from a single center
Authors: Wang Yawei , Wang Yan , Zou Liaonan , Deng Lingna , Wu Meilong , Fan Lili , Jiang Jiling , An Tailai
Published: March 2023

Background: More and more extremely elderly patients (≥85) with colorectal cancer are being encountered in routine clinical practice. For these patients, the laparoscopic approach has been considered as a less invasive alternative. Whereas, it is not so easy for us to accomplish controlled clinical trials among extremely elderly patients. The present study was performed to evaluate the feasibility and safety of laparoscopic surgery for extremely elderly patients.
Materials and Methods: Medical records of extremely elderly patients with colorectal cancer who had underwent curative laparoscopic or open surgery were retrospectively reviewed. The clinicopathological characteristics and surgery-related outcomes of these patients were recorded and analyzed.
Results: A total of 110 extremely elderly patients had undergone curative surgery at our center, including 47 open surgeries and 63 laparoscopic surgeries. The mean operation times for open surgery and laparoscopic surgery were 199.94 (±64.17) and 195.71 (±77.85) minutes, respectively. Intraoperative blood transfusion during laparoscopic surgery (258.73±549.38 ml) was not significantly different from that for open surgery (160.64±273.05 ml) (P=0.264). In the open group, 2 patients experienced major complications. In the laparoscopic group, 4 patients experienced major complications. The laparoscopic group was not significantly different from the open group in terms of overall survival (P=0.763) and recurrence-free survival (P=0.323). Of these 110 patients, the oldest was a woman aged 100 years and 10 months who had undergone curative laparoscopic sigmoidectomy.
Conclusion: For extremely elderly patients with colorectal cancer, laparoscopic surgery is feasible and safe. We report the success of laparoscopic surgery for a patient aged 100 years with sigmoid colon cancer.
Screening the effects of additional donors, numbers and positions of π-spacers on perylene- based sensitizers in dye-sensitized solar cell applications
Authors: Nicksonsebastin D. , Pounraj P. , Paulraj E. Isac , Mani N. , Prasath M.
Published: March 2023

The novel sensitizers are framed by perylene as donor with diphehylamine as auxiliary donor, thiophene and cyanovinyl as π-spacers and cyano acrylic acid as an acceptor unit. The optimised structure for the designed sensitizers was determined utilizing density functional theory, and the electronic structure was determined utilizing time-dependent density functional theory through the B3LYP/6-311G (d, p) basis set in the gas phase and Dimethylformamide (DMF) phase. The frontier molecular orbital results have significantly lower HOMO-LUMO energy gap values for better electron injection and electron regeneration. All designed sensitizers have absorption spectra values in the range of visible to near IR region. In the present work, the position and number of π-spacers reduces the HOMO-LUMO gap, the redshift of the absorption spectrum, and increases the high light harvesting efficiency. The findings reveal that the number of π-spacers improves the power conversion efficiency (PCE) of the solar cells.
Constructing and applying an evaluation index system to assess the techno-economic effects of rice mechanization in China
Authors: Ouyang Shumiao , Lin Jinlong , Yao Mingyin
Published: March 2023

This paper applies the Wuli-Shili-Renli (WSR) methodology to construct an index system that evaluates the technical and economic effects of rice mechanization (TER). The system includes 26 indicators, and the study calculates the weight of each indicator using hierarchical analysis (AHP). The study also includes an empirical analysis of the TER in China and main producing provinces from 2008 to 2018. The study yielded the following key results. 1) The TER in China increased in its fluctuations from 2008 to 2018. 2) Land productivity and labor productivity increased significantly, positively contributing to the TER in China. Indicators such as seed usage per unit of operating area decreased steadily, negatively affecting the TER in China. The efficiency of agricultural machinery management and other organizations continued to improve during the study period, increasing the TER. 3) Most of the regions with high TER are located in the dominant main production areas in the northeast and the dominant main production areas in the Yangtze River basin. Most of the rice producing provinces in the southeast production areas ranked in the middle and lower levels. This paper concludes that the TER in China could be improved by improving the refinement of agricultural machinery operations, increasing the degree of large-scale land management in small-plot provinces such as Yunnan, and increasing the research and development of suitable agricultural machinery.