bluuebunny/crossref_metadata_2025 huggingface dataset:
Biomechanical Behavior Characterization and Constitutive Models of Porcine Trabecular Tibiae
Authors: Quintana-Barcia Covadonga , Rodríguez Cristina , Álvarez Guillermo , Maestro Antonio
Published: June 2021

Customizing any trauma surgery requires prior planning by surgeons. Nowadays, the use of numerical tools is increasingly needed to facilitate this planning. The success of this analysis begins with the definition of all the mechanical constitutive models of the materials implied. Our target is the trabecular bone because almost all trauma surgeries are closely related to it. This work focuses on the experimental characterization of porcine trabecular tibiae and defining its best constitutive model. Therefore, different types of compression tests were performed with tibia samples. Once the potential constitutive models were defined, stress–strain state from numerical approaches were compared with the corresponding experimental results. Experimental results from uniaxial compression tests showed than trabecular bone exhibits clear anisotropy with more stiffness and strength when it is loaded in the tibia longitudinal direction. Results from confined compression tests confirmed that the plastic behavior of trabecular bone depends on the hydrostatic and deviatoric invariants, so an alternative formulation (crushable foam volumetric (CFV)) has been proposed to describe its behavior. A new method to obtain CFV characteristic parameters has been developed and validated. Predictions of the CFV model better describe trabecular bone mechanical behavior under confined conditions. In other cases, classical plasticity formulations work better.
CD3+, CD8+, CD4+ and FOXP3+ T Cells in the Immune Microenvironment of Small Bowel Neuroendocrine Tumors
Authors: Hiltunen Niko , Väyrynen Juha P. , Böhm Jan , Helminen Olli
Published: June 2021

The role of inflammation in neuroendocrine tumors is poorly known. The purpose of this study was to characterize the densities of CD3+, CD8+, CD4+ and FOXP3+ T cells in small bowel neuroendocrine tumors (SB-NETs), SB-NET lymph node metastases and gastric neuroendocrine tumors (G-NETs) to assess the prognostic role of immune cell infiltrates in SB-NETs. The final cohort included 113 SB-NETs, 75 SB-NET lymph node metastases and 19 G-NETs from two Finnish hospitals. CD3+- and CD8+-based immune cell score (ICS), and other T cell densities were evaluated. Survival analyses of SB-NETs and SB-NET lymph node metastases were performed with the Kaplan-Meier method and Cox regression adjusted for confounders. The primary outcome was disease-specific survival (DSS). No significant difference in DSS was seen between low and high ICS groups in SB-NETs at 5 years (92.6% vs. 87.8%) or 10 years (53.8% vs. 79.4%), p = 0.507, or in SB-NET lymph node metastases at 5 years (88.9% vs. 90.4%) or 10 years (71.1% vs. 59.8%), p = 0.466. Individual densities of the examined T cell types showed no correlation with prognosis either. SB-NETs and lymph node metastases had similar inflammatory cell profiles, whereas in G-NETs CD3+ and CD8+ T cells were particularly more abundant. In SB-NETs, ICS or T cell densities showed no correlation with prognosis.
The Value of Heart Rhythm Complexity in Identifying High-Risk Pulmonary Hypertension Patients
Authors: Tang Shu-Yu , Ma Hsi-Pin , Hung Chi-Sheng , Kuo Ping-Hung , Lin Chen , Lo Men-Tzung , Hsu Hsao-Hsun , Chiu Yu-Wei , Wu Cho-Kai , Tsai Cheng-Hsuan , Lin Yen-Tin , Peng Chung-Kang , Lin Yen-Hung
Published: June 2021

Pulmonary hypertension (PH) is a fatal disease—even with state-of-the-art medical treatment. Non-invasive clinical tools for risk stratification are still lacking. The aim of this study was to investigate the clinical utility of heart rhythm complexity in risk stratification for PH patients. We prospectively enrolled 54 PH patients, including 20 high-risk patients (group A; defined as WHO functional class IV or class III with severely compromised hemodynamics), and 34 low-risk patients (group B). Both linear and non-linear heart rate variability (HRV) variables, including detrended fluctuation analysis (DFA) and multiscale entropy (MSE), were analyzed. In linear and non-linear HRV analysis, low frequency and high frequency ratio, DFAα1, MSE slope 5, scale 5, and area 6–20 were significantly lower in group A. Among all HRV variables, MSE scale 5 (AUC: 0.758) had the best predictive power to discriminate the two groups. In multivariable analysis, MSE scale 5 (p = 0.010) was the only significantly predictor of severe PH in all HRV variables. In conclusion, the patients with severe PH had worse heart rhythm complexity. MSE parameters, especially scale 5, can help to identify high-risk PH patients.
Application of Matrix VFD for Power Factor Improvement in LED Lighting Sources Loaded Power Distribution Lines
Authors: Petrauskas Gytis , Svinkunas Gytis
Published: June 2021

In this paper, a novel approach to matrix-converter-based variable frequency drives is presented. It is proposed that these drives are used to provide or draw out reactive power from the power distribution line, keeping the power factor close to unit and, simultaneously, performing their primary function of motor powering and speed control. This application of matrix-converter-based variable frequency drives is required due to the need to compensate for capacitive reactive power generated by light emitting diode lighting devices. In this study, the reactive power compensation range of the matrix-converter-based variable frequency drive is determined, and a method is proposed to extend the compensation range.
Numerical and Physical Modeling of a Tension-Leg Platform for Offshore Wind Turbines
Authors: Walia Daniel , Schünemann Paul , Hartmann Hauke , Adam Frank , Großmann Jochen
Published: June 2021

In order to tap the world wide offshore wind resources above deep waters, cost efficient floating platforms are inevitable. Tension-Leg Platforms (TLPs) could enable that crucial cost reduction in floating wind due to their smaller size and lighter weight compared to spars and semi-submersibles. The continuous development of the GICON®-TLP is driven by computer-aided engineering. So-called aero-hydro-servo-elastic coupled simulations are state-of-the-art for predicting loads and simulating the global system behavior for floating offshore wind turbines. Considering the complexity of such simulations, it is good scientific praxis to validate these numerical calculations by use of scaled model testing. This paper addresses the setup of the scaled model testing as carried out at the offshore basin of the École Centrale de Nantes, as well as the numerical model for the GICON®-TLP. The results of dedicated decay tests of the scaled model are used to validate the computational model at the first stage and to determine the natural frequencies of the system. Besides different challenges to the scaled model during the survey, it was possible to take these difficulties into account when updating the numerical model. The results show good agreements for the tank tests and the numerical model.
An Innovative Approach to Energy Consumer Segmentation—A Behavioural Perspective. The Case of the Eco-Bot Project
Authors: Słupik Sylwia , Kos-Łabędowicz Joanna , Trzęsiok Joanna
Published: June 2021

Energy consumption impacts the environment, humans’ well-being, comfort and quality of life. The article aimed to develop the original model of energy consumer segmentation, based on behavioural variables, which influence consumer decisions and motivations regardless of demographic, geographic and socio-cultural differences. The innovative contribution is the segmentation procedure, which fills the existing research gap and can be treated as a universal tool serving various groups of stakeholders for creating and implementing sustainable development policies. The methodology used for the segmentation is based on the original algorithm and involves classifying a consumer into the most appropriate group based on the measurement of the distance between the ideal class representative and a particular respondent. Several distance measures (e.g., Sokal–Michener, Goodall, Lin) were used, while the similarity of those classifications was verified using the adjusted Rand index. The segmentation involved adopting—a priori—five basic classes of consumers, varying in terms of motivation to save energy. The validation performed on a sample of 1606 respondents, carried out as part of the eco-bot project, verified both the classification approach adopted in the study and the accuracy of the assumptions. The application of the distance measures chosen for the study allowed for the assignment of 96.1% of the respondents to the appropriate classes, which yielded the following distribution: EI (33.9% of the respondents); DS (33.1%), AE (17.2%), O (7%) and I (4.9%).
Laminar Burning Velocity and Ignition Delay Time of Oxygenated Biofuel
Authors: Mosisa Wako Fekadu , Pio Gianmaria , Salzano Ernesto
Published: June 2021

The need for lowering the environmental impacts has incentivized the investigation of biomass and biofuels as possible alternative sources for energy supply. Among the others, oxygenated bio-derived molecules such as alcohols, esters, acids, aldehydes, and furans are attractive substances as chemical feedstock and for sustainable energy production. Indeed, the presence of oxygen atoms limits the production of aromatic compounds, improves combustion efficiency (thus heat production) and alleviates the formation of carbon soot. On the other hand, the variability of their composition has represented one of the major challenges for the complete characterization of combustion behaviour. This work gives an overview of the current understanding of the detailed chemical mechanisms, as well as experimental investigations characterizing the combustion process of these species, with an emphasis on the laminar burning velocity and the ignition delay time. From the review, the common intermediates for the most relevant functional groups and combustion of biofuels were identified. The gathered information can be intended for the sake of core mechanism generation.
Relationship between Energy Consumption and Economic Growth in European Countries: Evidence from Dynamic Panel Data Analysis
Authors: Topolewski Łukasz
Published: June 2021

The aim of the article is to empirically verify the relationship between energy consumption and economic growth. The time scope of this study covers the period of 2008–2019. The scope of analyzed subjects covers 34 European countries, 27 of which are currently members of the European Union. European countries consume large amounts of energy, so it is worth investigating the effect of reducing energy consumption on the process of economic growth. For this purpose, dynamic panel models were used. The research methods included the use of dynamic panel models, taking into account the Arellano and Bond and Blundell and Bond estimators. The results made it possible to identify the relationship between energy consumption and economic growth. It was found that, in the short term, increases in production will result in a statistically significant increase in energy consumption. Importantly, in the long term, this impact is also statistically significant and positive. On the other hand, taking into account the second of the estimated models, it can be concluded that, in the short term, increases in energy consumption do not cause changes in the rate of economic growth. The verification of this relationship in the long term also does not confirm it. In summary, it can be stated that a one-way relationship (in the short and in the long term), directed from economic growth towards energy consumption, was identified.
Effect of Aeration on Yeast Community Structure and Volatile Composition in Uninoculated Chardonnay Wines
Authors: Varela Cristian , Cuijvers Kathleen , Van Den Heuvel Steven , Rullo Mark , Solomon Mark , Borneman Anthony , Schmidt Simon
Published: June 2021

Uninoculated wines are regarded as having improved mouthfeel and texture and more complex flavor profiles when compared to wines inoculated with commercial S. cerevisiae strains. Uninoculated fermentation involves a complex microbial succession of yeasts and bacteria during fermentation. Microbial population dynamics are affected by several factors that can ultimately determine if a particular species or strain contributes to wine aroma and flavor. In this work, we have studied the effect of aeration, a common winemaking practice, on the yeast microbiota during uninoculated Chardonnay wine fermentation. The timing of aeration and then aeration intensity were evaluated across two successive vintages. While the timing of aeration significantly impacted fermentation efficiency across oxygen treatments, different levels of aeration intensity only differed when compared to the non-aerated control ferments. Air addition increased the viable cell population size of yeast from the genera Hanseniaspora, Lachancea, Metschnikowia and Torulaspora in both vintages. While in 2019, a high relative abundance was found for Hanseniaspora species in aerated ferments, in 2020, T. delbrueckii was visibly more abundant than other species in response to aeration. Accompanying the observed differences in yeast community structure, the chemical profile of the finished wines was also different across the various aeration treatments. However, excessive aeration resulted in elevated concentrations of ethyl acetate and acetic acid, which would likely have a detrimental effect on wine quality. This work demonstrates the role of aeration in shaping yeast population dynamics and modulating a volatile profile in uninoculated wines, and highlights the need for careful air addition to avoid a negative sensory impact on wine flavor and aroma.
Experimental and Numerical Investigation of Gaseous Detonation in a Narrow Channel with Obstacles
Authors: Krivosheyev Pavel N. , Novitski Alexey O. , Sevrouk Kirill L. , Penyazkov Oleg G. , But Ivan I. , Kasimov Aslan R.
Published: June 2021

Gaseous detonation propagation in a thin channel with regularly spaced cylindrical obstacles was investigated experimentally and numerically. The wave propagation with substantial velocity deficits is observed and the details of its propagation mechanism are described based on experimental measurements of the luminosity and pressure and on three-dimensional flow fields obtained by numerical simulations. Both experiments and simulations indicate a significant role of shock–shock and shock–obstacle interactions in providing high-temperature conditions necessary to sustain the reaction wave propagation.
Tunable Human Myocardium Derived Decellularized Extracellular Matrix for 3D Bioprinting and Cardiac Tissue Engineering
Authors: Basara Gozde , Ozcebe S. Gulberk , Ellis Bradley W. , Zorlutuna Pinar
Published: June 2021

The generation of 3D tissue constructs with multiple cell types and matching mechanical properties remains a challenge in cardiac tissue engineering. Recently, 3D bioprinting has become a powerful tool to achieve these goals. Decellularized extracellular matrix (dECM) is a common scaffold material due to providing a native biochemical environment. Unfortunately, dECM’s low mechanical stability prevents usage for bioprinting applications alone. In this study, we developed bioinks composed of decellularized human heart ECM (dhECM) with either gelatin methacryloyl (GelMA) or GelMA-methacrylated hyaluronic acid (MeHA) hydrogels dual crosslinked with UV light and microbial transglutaminase (mTGase). We characterized the bioinks’ mechanical, rheological, swelling, printability, and biocompatibility properties. Composite GelMA–MeHA–dhECM (GME) hydrogels demonstrated improved mechanical properties by an order of magnitude compared to the GelMA–dhECM (GE) hydrogels. All hydrogels were extrudable and compatible with human induced pluripotent stem cell derived cardiomyocytes (iCMs) and human cardiac fibroblasts (hCFs). Tissue-like beating of the printed constructs with striated sarcomeric alpha-actinin and connexin 43 expression was observed. The order of magnitude difference between the elastic modulus of these hydrogel composites offers applications in in vitro modeling of the myocardial infarct boundary. Here, as a proof of concept, we created an infarct boundary region with control over the mechanical properties along with the cellular and macromolecular content through printing iCMs with GE bioink and hCFs with GME bioink.
Linear Dynamic Viscoelasticity of Dual Cross-Link Poly(Vinyl Alcohol) Hydrogel with Determined Borate Ion Concentration
Authors: Taniguchi Takuro , Urayama Kenji
Published: June 2021

We investigated the linear dynamic viscoelasticity of dual cross-link (DC) poly(vinyl alcohol) (PVA) (DC-PVA) hydrogels with permanent and transient cross-links. The concentrations of incorporated borate ions to form transient cross-links in the DC-PVA hydrogels (CBIN) were determined by the azomethine-H method. The dynamic viscoelasticity of the DC-PVA hydrogel cannot be described by a simple sum of the dynamic viscoelasticity of the PVA gel with the same permanent cross-link concentration and the PVA aqueous solution with the same borate ion concentration (CB = CBIN) as in the DC-PVA gel. The DC-PVA hydrogel exhibited a considerably higher relaxation strength, indicating that the introduction of permanent cross-links into temporary networks increases the number of viscoelastic chains with finite relaxation times. In contrast, the relaxation frequency (ωc) (given by the frequency at the maximum of loss modulus) for the DC-PVA hydrogel was slightly lower but comparable to that for a dilute PVA solution with the same CB. This signifies that the relaxation dynamics of the DC-PVA hydrogels is essentially governed by the lifetime of an interchain transient cross-link (di-diol complex of boron). The effect of permanent cross-linking on the relaxation dynamics was observed in the finite broadening of the relaxation-time distribution in the long time region.
Feeling Seen: Aboriginal and Torres Strait Islander LGBTIQ+ Peoples, (In)Visibility, and Social-Media Assemblages
Authors: Farrell Andrew
Published: June 2021

This article explores shifting social arrangements on social media as experienced by Aboriginal and Torres Strait Islander gay, lesbian, bisexual, transgender, intersex, and queer (LGBTIQ+) peoples. These digital social assemblages are situated within a broader context of heteropatriarchy and settler colonialism in Australia and beyond. In digital spaces, multiple marginalised groups encounter dialogic engagements with their friends, followers, networks, and broader publics. The exploration of how digital discourses (in)visibilise Indigenous LGBTIQ+ diversities underline the intimate and pervasive reach of settler colonialism, and highlight distinctly queer Indigenous strategies of resistance. Through the experience of Aboriginal and Torres Strait Islander LGBTIQ+ artists, activists, and celebrities, this article demonstrates the shifting unities and disunities that shape how we come to know and understand the complexities of Indigenous LGBTIQ+ identities and experiences.
A Short-Term Quantitative Precipitation Forecasting Approach Using Radar Data and a RAP Model
Authors: Wang Yadong , Tang Lin
Published: June 2021

Very short-term (0~3 h) radar-based quantitative precipitation forecasting (QPF), also known as nowcasting, plays an essential role in flash flood warning, water resource management, and other hydrological applications. A novel nowcasting method combining radar data and a model wind field was developed and validated with two hurricane precipitation events. Compared with several existing nowcasting approaches, this work attempts to enhance the prediction capabilities from two major aspects. First, instead of using a radar reflectivity field, this work proposes the use of the rainfall rate field estimated from polarimetric radar variables in the motion field derivation. Second, the derived motion field is further corrected by the Rapid Refresh (RAP) model field. With the corrected motion field, the future rainfall rate field is predicted through a linear extrapolation method. The proposed method was validated using two hurricanes: Harvey and Irma. The proposed work shows an enhanced performance according to statistical scores. Compared with the model only and centroid-tracking only approaches, the average probability of detection (POD) increases about 25% and 50%; the average critical success index (CSI) increases about 20% and 37%; and the average false alarm rate (FAR) decreases about 14% and 16%, respectively.
Leaving the Quiet Jungle Path: Introduction to Maya Anthropological Archaeology
Authors: Fisher Chelsea , Chase Arlen F.
Published: June 2021

In her book Maya Cultural Heritage: How Archaeologists and Indigenous Communities Engage the Past (Roman and Littlefield 2016), Patricia McAnany urges archaeologists who work in the Maya region (i [...]
Flood Mitigation Measure and Water Storage in East Africa: An Analysis for the Rio Muaguide, Mozambique
Authors: Rrokaj Sara , Corti Benedetta , Giovannini Anna , Cancelliere Giorgio , Biotto Davide , Radice Alessio
Published: June 2021

In the last century, floods have been more frequently hitting population and human activity, especially in the sub-Saharan context. The aim of this study is to propose suitable flood mitigation measures for the downstream part of the Rio Muaguide, which flows in northern Mozambique. In this terminal part of the river, the bed has been buried by sediment in many reaches; due to the reduction of the section conveyance, wide areas are inundated during the rainy season with negative consequences for several villages relying on subsistence agriculture. The design of any measure requires quantitative determinations but, as many less developed countries, Mozambique is affected by data scarcity. Therefore, in this study global and freely available data have been used to perform hydrologic and two-dimensional hydro-dynamic modelling, finally producing a flood hazard map. Particular care has been put into a critical analysis of several data sources, in terms of their suitability for the purposes of the work. Based on the modelling results and on field evidence, an intervention has been proposed with a double functionality of mitigating the effects of periodic floods and storing water to be used by the agricultural community during drier seasons. The proposed intervention combines restoring a sedimentation-less shape of the river sections and exploiting a natural basin as a storage basin. The methods applied and the intervention proposed for the Rio Muaguide are prototypal for several analogous streams in the coastal portion of Mozambique.
Novel Techniques to Improve Precise Cell Injection
Authors: Linzenbold Walter , Fech Andreas , Hofmann Manuela , Aicher Wilhelm K. , Enderle Markus D.
Published: June 2021

We noted recently that the injection of cells with a needle through a cystoscope in the urethral sphincter muscle of pigs failed to deposit them nearby or at the intended target position in about 50% of all animals investigated (n > 100). Increasing the chance for precise cell injection by shotgun approaches employing several circumferential injections into the sphincter muscle bears the risk of tissue injury. In this study, we developed and tested a novel needle-free technique to precisely inject cells in the urethral sphincter tissue, or other tissues, using a water-jet system. This system was designed to fit in the working channels of endoscopes and cystoscopes, allowing a wide range of minimally invasive applications. We analyze key features, including the physical parameters of the injector design, pressure ranges applicable for tissue penetration and cell injections and biochemical parameters, such as different compositions of injection media. Our results present settings that enable the high viability of cells post-injection. Lastly, the method is suitable to inject cells in the superficial tissue layer and in deeper layers, required when the submucosa or the sphincter muscle of the urethra is targeted.
Cardioprotective Effects of PPARβ/δ Activation against Ischemia/Reperfusion Injury in Rat Heart Are Associated with ALDH2 Upregulation, Amelioration of Oxidative Stress and Preservation of Mitochondrial Energy Production
Authors: Papatheodorou Ioanna , Galatou Eleftheria , Panagiotidis Georgios-Dimitrios , Ravingerová Táňa , Lazou Antigone
Published: June 2021

Accumulating evidence support the cardioprotective properties of the nuclear receptor peroxisome proliferator activated receptor β/δ (PPARβ/δ); however, the underlying mechanisms are not yet fully elucidated. The aim of the study was to further investigate the mechanisms underlying PPARβ/δ-mediated cardioprotection in the setting of myocardial ischemia/reperfusion (I/R). For this purpose, rats were treated with PPARβ/δ agonist GW0742 and/or antagonist GSK0660 in vivo and hearts were subjected to ex vivo global ischemia followed by reperfusion. PPARβ/δ activation improved left ventricular developed pressure recovery, reduced infarct size (IS) and incidence of reperfusion-induced ventricular arrhythmias while it also up-regulated superoxide dismutase 2, catalase and uncoupling protein 3 resulting in attenuation of oxidative stress as evidenced by the reduction in 4-hydroxy-2-nonenal protein adducts and protein carbonyl formation. PPARβ/δ activation also increased both mRNA expression and enzymatic activity of aldehyde dehydrogenase 2 (ALDH2); inhibition of ALDH2 abrogated the IS limiting effect of PPARβ/δ activation. Furthermore, upregulation of PGC-1α and isocitrate dehydrogenase 2 mRNA expression, increased citrate synthase activity as well as mitochondrial ATP content indicated improvement in mitochondrial content and energy production. These data provide new mechanistic insight into the cardioprotective properties of PPARβ/δ in I/R pointing to ALDH2 as a direct downstream target and suggesting that PPARβ/δ activation alleviates myocardial I/R injury through coordinated stimulation of the antioxidant defense of the heart and preservation of mitochondrial function.
In-Pero: Exploiting Deep Learning Embeddings of Protein Sequences to Predict the Localisation of Peroxisomal Proteins
Authors: Anteghini Marco , Martins dos Santos Vitor , Saccenti Edoardo
Published: June 2021

Peroxisomes are ubiquitous membrane-bound organelles, and aberrant localisation of peroxisomal proteins contributes to the pathogenesis of several disorders. Many computational methods focus on assigning protein sequences to subcellular compartments, but there are no specific tools tailored for the sub-localisation (matrix vs. membrane) of peroxisome proteins. We present here In-Pero, a new method for predicting protein sub-peroxisomal cellular localisation. In-Pero combines standard machine learning approaches with recently proposed multi-dimensional deep-learning representations of the protein amino-acid sequence. It showed a classification accuracy above 0.9 in predicting peroxisomal matrix and membrane proteins. The method is trained and tested using a double cross-validation approach on a curated data set comprising 160 peroxisomal proteins with experimental evidence for sub-peroxisomal localisation. We further show that the proposed approach can be easily adapted (In-Mito) to the prediction of mitochondrial protein localisation obtaining performances for certain classes of proteins (matrix and inner-membrane) superior to existing tools.
Genomic Analyses of Pediatric Acute Lymphoblastic Leukemia Ph+ and Ph-Like—Recent Progress in Treatment
Authors: Kaczmarska Agnieszka , Śliwa Patrycja , Zawitkowska Joanna , Lejman Monika
Published: June 2021

Pediatric acute lymphoblastic leukemia (ALL) with t(9;22)(q34;q11.2) is a very rare malignancy in children. Approximately 3–5% of pediatric ALL patients present with the Philadelphia chromosome. Previously, children with Ph+ had a poor prognosis, and were considered for allogeneic stem cell transplantation (allo-HSCT) in their first remission (CR1). Over the last few years, the treatment of childhood ALL has significantly improved due to standardized research protocols. Hematopoietic stem cell transplantation (HSCT) has been the gold standard therapy in ALL Ph+ patients, but recently first-generation tyrosine kinase inhibitor (TKI)-imatinib became a major milestone in increasing overall survival. Genomic analyses give the opportunity for the investigation of new fusions or mutations, which can be used to establish effective targeted therapies. Alterations of the IKZF1 gene are present in a large proportion of pediatric and adult ALL Ph+ cases. IKZF1 deletions are present in ~15% of patients without BCR-ABL1 rearrangements. In BCR-ABL1-negative cases, IKZF1 deletions have been shown to have an independent prognostic impact, carrying a three-fold increased risk of treatment failure. The prognostic significance of IKZF1 gene aberrations in pediatric ALL Ph+ is still under investigation. More research should focus on targeted therapies and immunotherapy, which is not associated with serious toxicity in the same way as classic chemotherapy, and on the improvement of patient outcomes. In this review, we provide a molecular analysis of childhood ALL with t(9;22)(q34;q11.2), including the Ph-like subtype, and of treatment strategies.
Pathophysiological Responses and Roles of Astrocytes in Traumatic Brain Injury
Authors: Michinaga Shotaro , Koyama Yutaka
Published: June 2021

Traumatic brain injury (TBI) is immediate damage caused by a blow to the head resulting from traffic accidents, falls, and sporting activity, which causes death or serious disabilities in survivors. TBI induces multiple secondary injuries, including neuroinflammation, disruption of the blood–brain barrier (BBB), and brain edema. Despite these emergent conditions, current therapies for TBI are limited or insufficient in some cases. Although several candidate drugs exerted beneficial effects in TBI animal models, most of them failed to show significant effects in clinical trials. Multiple studies have suggested that astrocytes play a key role in the pathogenesis of TBI. Increased reactive astrocytes and astrocyte-derived factors are commonly observed in both TBI patients and experimental animal models. Astrocytes have beneficial and detrimental effects on TBI, including promotion and restriction of neurogenesis and synaptogenesis, acceleration and suppression of neuroinflammation, and disruption and repair of the BBB via multiple bioactive factors. Additionally, astrocytic aquaporin-4 is involved in the formation of cytotoxic edema. Thus, astrocytes are attractive targets for novel therapeutic drugs for TBI, although astrocyte-targeting drugs have not yet been developed. This article reviews recent observations of the roles of astrocytes and expected astrocyte-targeting drugs in TBI.
Adsorptive and Coagulative Removal of Trace Metals from Water Using Surface Modified Sawdust-Based Cellulose Nanocrystals
Authors: Oyewo Opeyemi A. , Ramaila Sam , Mavuru Lydia , Leswifi Taile , Onyango Maurice S.
Published: June 2021

The presence of toxic metals in surface and natural waters, even at trace levels, poses a great danger to humans and the ecosystem. Although the combination of adsorption and coagulation techniques has the potential to eradicate this problem, the use of inappropriate media remains a major drawback. This study reports on the application of NaNO2/NaHCO3 modified sawdust-based cellulose nanocrystals (MCNC) as both coagulant and adsorbent for the removal of Cu, Fe and Pb from aqueous solution. The surface modified coagulants, prepared by electrostatic interactions, were characterized using Fourier transform infrared, X-ray diffraction (XRD), and scanning electron microscopy/energy-dispersive spectrometry (SEM/EDS). The amount of coagulated/adsorbed trace metals was then analysed using inductively coupled plasma atomic emission spectroscopy (ICP-AES). SEM analysis revealed the patchy and distributed floccules on Fe-flocs, which was an indication of multiple mechanisms responsible for Fe removal onto MCNC. A shift in the peak position attributed to C2H192N64O16 from 2θ = 30 to 24.5° occurred in the XRD pattern of both Pb- and Cu-flocs. Different process variables, including initial metal ions concentration (10–200 mg/L), solution pH (2–10), and temperature (25–45 °C) were studied in order to investigate how they affect the reaction process. Both Cu and Pb adsorption followed the Langmuir isotherm with a maximum adsorption capacity of 111.1 and 2.82 mg/g, respectively, whereas the adsorption of Fe was suggestive of a multilayer adsorption process; however, Fe Langmuir maximum adsorption capacity was found to be 81.96 mg/g. The sequence of trace metals removal followed the order: Cu > Fe > Pb. The utilization of this product in different water matrices is an effective way to establish their robustness.
“Never Trust to General Impressions, My Boy, but Concentrate Yourself upon Details”: An Unusual and Challenging Presentation of Pheochromocytoma
Authors: Barbero Umberto , Matta Mario , Caprino Mirko Parasiliti , Maletta Francesca , Giraudo Giuseppe , Frea Simone , De Benedictis Michele , Maccario Mauro
Published: June 2021

We present the case of a 45-year-old woman admitted to our unit with acute heart failure and cardiogenic shock, requiring an intra-aortic balloon pump insertion and inotropes and vasopressors infusion. Despite such treatment, the patient developed multi organ failure and intravascular disseminated coagulation with haemolysis. The initial diagnosis of acute myocarditis was subsequently denied by the finding of bilateral adrenal masses by MRI scan, and urine and plasma metanephrines measurements confirmed a pheochromocytoma (PCC). Genetic analysis revealed a mutation in the neurofibromatosis type 1 (NF1) gene, and an accurate physical examination drew attention to small cafè-au-lait spots, usually associated with this syndrome. PCC diagnosis should be promptly considered in patients presenting with unexplained acute heart failure and cardiogenic shock of unknown origin, considering its life-threatening complications and the good prognosis after radical surgery.
The Impact of Intracytoplasmic Sperm Injection in Non-Male Factor Infertility—A Critical Review
Authors: Glenn Tanya L. , Kotlyar Alex M. , Seifer David B.
Published: June 2021

Intracytoplasmic sperm injection (ICSI) was originally designed to overcome barriers due to male factor infertility. However, a surveillance study found that ICSI use in non-male factor infertility increased from 15.4% to 66.9% between 1996 and 2012. Numerous studies have investigated fertilization rate, total fertilization failure, and live birth rate per cycle (LBR), comparing the use of ICSI versus conventional in vitro fertilization (IVF) for non-male factor infertility. The overwhelming conclusion shows no increase in fertilization rate or LBR per cycle with the use of ICSI for non-male factor infertility. The overuse of ICSI is likely related to the desire to avoid a higher rate of total fertilization failure in IVF. However, data supporting the benefit of using ICSI for non-male factor infertility is lacking, and 33 couples would need to be treated with ICSI unnecessarily to avoid one case of total fertilization failure. Such practice increases the cost to the patient, increases the burden on embryologist’s time, and is a misapplication of resources. Additionally, there remains conflicting data regarding the safety of offspring conceived by ICSI and potential damage to the oocyte. Thus, the use of ICSI should be limited to those with male factor infertility or a history of total fertilization factor infertility due to uncertainties of potential adverse impact and lack of proven benefit in non-male factor infertility.
Candida albicans and Oral Carcinogenesis. A Brief Review
Authors: Di Cosola Michele , Cazzolla Angela Pia , Charitos Ioannis Alexandros , Ballini Andrea , Inchingolo Francesco , Santacroce Luigi
Published: June 2021

Current medical knowledge and research on patients’ management are still evolving, and several protocols on minimizing risk of infection by Candida spp. among the population have developed. The aim of this work is to review the epidemiological and biomolecular characteristics and the various histopathological carcinogenesis hypothesis mechanisms that can occur during Candida albicans infections. Current evidence from the literature on the role of C. albicans during potentially malignant oral disorders and oral cancer has been sought. Thus, these biomolecular processes can give or contribute to benign lesions, also in precancerous or cancerous situations. Alongside this, the physiological microorganism oral flora (microbiota) can play a crucial role in maintaining oral health during those infections and therefore avoid carcinogenesis.
Kindness and Control: The Political Leadership of Jacinda Ardern in the Aotearoa New Zealand COVID-19 Media Conferences
Authors: Craig Geoffrey
Published: June 2021

Aotearoa New Zealand Prime Minister Jacinda Ardern’s management of COVID-19 media conferences demonstrated a complex negotiation of expressions of ‘kindness’ and political ‘control’ as Ardern sought to unify the national public and implement a national emergency that closed the border and suspended civil liberties and freedom of movement. This article considers the distinctive positive leadership style of Ardern while also demonstrating the ways it is grounded in the exigencies of the political field. A critical reading of Ardern’s media conference answers reveals four nominated categories: positive assertions, management of conflict/disagreement, delineation of politician role/responsibility, and political evasion. The four categories map the terrain of agreement and disagreement and they locate the subject position of the politician on that terrain.
Digitization, Epistemic Proximity, and the Education System: Insights from a Bibliometric Analysis
Authors: Fiore Ugo , Florea Adrian , Kifor Claudiu Vasile , Zanetti Paolo
Published: June 2021

Advances in IoT, AI, Cyber-Physical Systems, Computational Intelligence, and Big Data Analytics require organizations and workforce to be able and willing to learn how to interact with digital technology. In organizations, coordination and cooperation between actors with expertise in business and technology is fundamental, but integration is hard without understanding the terminology and problems of the interlocutor. Epistemic proximity becomes prominent, underlining the importance of an education focused on flexibility, willingness to cope with the unknown, and interdisciplinarity. The main goal of this work is to provide a perspective on how the education system is evolving to support organizations in the digitization era through a quantitative analysis of literature. More than 170,000 papers were selected from the Scopus database, matching a wide set of keywords related with innovation, problem solving, and organizational change. Patterns in the co-occurrence of keywords were studied. In addition, similarities and differences in the distribution of relevant themes across disciplinary areas, as well as their evolution since 2000, were analyzed. Academic interest is found to be generally increasing over the years in all disciplines, although considerable fluctuations can be observed. This variation is found to be nonuniform in the macroareas.
A Process for Hydrogen Production from the Catalytic Decomposition of Formic Acid over Iridium—Palladium Nanoparticles
Authors: Alshammari Hamed M. , Alotaibi Mohammad Hayal , Aldosari Obaid F. , Alsolami Abdulellah S. , Alotaibi Nuha A. , Alzahrani Yahya A. , Alhumaimess Mosaed S. , Alotaibi Raja L. , El-Hiti Gamal A.
Published: June 2021

The present study investigates a process for the selective production of hydrogen from the catalytic decomposition of formic acid in the presence of iridium and iridium–palladium nanoparticles under various conditions. It was found that a loading of 1 wt.% of 2% palladium in the presence of 1% iridium over activated charcoal led to a 43% conversion of formic acid to hydrogen at room temperature after 4 h. Increasing the temperature to 60 °C led to further decomposition and an improvement in conversion yield to 63%. Dilution of formic acid from 0.5 to 0.2 M improved the decomposition, reaching conversion to 81%. The reported process could potentially be used in commercial applications.
Synthesis and Characterization of a Novel Hydroquinone Sulfonate-Based Redox Active Ionic Liquid
Authors: Aidoudi Farida H. , Sinopoli Alessandro , Arunachalam Muthumeenal , Merzougui Belabbes , Aïssa Brahim
Published: June 2021

Introducing redox-active moieties into an ionic liquid (IL) structure is an exciting and attractive approach that has received increasing interest over recent years for a various range of energy applications. The so-called redox-active ionic liquids (RAILs) provide a highly versatile platform to potentially create multifunctional electroactive materials. Ionic liquids are molten salts consisting of ionic species, often having a melting point lower than 100 °C. Such liquids are obtained by combining a bulky asymmetric organic cation and a small anion. Here, we report on the synthesis of a novel RAIL, namely 1-butyl-3-methylimidazolium hydroquinone sulfonate ((BMIM)(HQS)). (BMIM)(HQS) was synthesized in a two-step procedure, starting by the quaternization of methylimidazole using butylchloride to produce 1-butyl-3-methylimidazolium chloride ((BMIM)(Cl)), and followed by the anion exchange reaction, where the chloride anion is exchanged with hydroquinone sulfonate. The resulting product was characterized by 1H NMR, 13C NMR, FT-IR spectroscopy, themogravimetric analysis, and differential scanning calorimetry, and shows a high stability up to 340 °C. Its electrochemical behavior was investigated using cyclic voltammetry at different temperatures and its viscosity analysis was also performed at variable temperatures. The electrochemical response of the presented RAIL was found to be temperature dependent and diffusion controlled. Overall, our results demonstrated that (BMIM)(mix of HQS and HSQ) is redox active and possesses high stability and low volatility, leading to the employment of this RAIL without any additional supporting electrolyte or additives.
Materials for High Temperature Liquid Lead Storage for Concentrated Solar Power (CSP) Air Tower Systems
Authors: Rinaldi Antonio , Barbieri Giuseppe , Kosykh Eduard , Szakalos Peter , Testani Claudio
Published: June 2021

Today the technical limit for solar towers is represented by the temperature that can be reached with current accumulation and exchange fluids (molten salts are generally adopted and the max temperatures are generally below 600 °C), even if other solutions have been suggested that reach 800 °C. An innovative solution based on liquid lead has been proposed in an ongoing experimental project named Nextower. The Nextower project aims to improve current technologies of the solar sector by transferring experience, originally consolidated in the field of nuclear plants, to accumulate heat at higher temperatures (T = 850–900 °C) through the use of liquid lead heat exchangers. The adoption of molten lead as a heat exchange fluid poses important criticalities of both corrosion and creep resistance, due to the temperatures and structural stresses reached during service. Liquid lead corrosion issues and solutions in addition to creep-resistant material selection are discussed. The experimental activities focused on technical solutions adopted to overcome these problems in terms of the selected materials and technologies. Corrosion laboratory tests have been designed in order to verify if structural 800H steel coated with 6 mm of FeCrAl alloy layers are able to resist the liquid lead attack up to 900 °C and for 1000 h or more. The metallographic results were obtained by mean of scanning electron microscopy with an energy dispersive microprobe confirm that the 800H steel shows no sign of corrosion after the completion of the tests.
The Structure of Gd3+-Doped Li2O and K2O Containing Aluminosilicate Glasses from Molecular Dynamics Simulations
Authors: Zekri Mohamed , Herrmann Andreas , Erlebach Andreas , Damak Kamel , Rüssel Christian , Sierka Marek , Maâlej Ramzi
Published: June 2021

Understanding the atomic structure of glasses is critical for developing new generations of materials with important technical applications. In particular, the local environment of rare-earth ions and their distribution and clustering is of great relevance for applications of rare earth-containing glasses in photonic devices. In this work, the structure of Gd2O3 doped lithium and potassium aluminosilicate glasses is investigated as a function of their network modifier oxide (NMO–Li2O, K2O) to aluminum oxide ratio using molecular dynamics simulations. The applied simulation procedure yields a set of configurations, the so-called inherent structures, of the liquid state slightly above the glass transition temperature. The generation of a large set of inherent structures allows a statistical sampling of the medium-range order of the Gd3+ ions with less computational effort compared to other simulation methods. The resulting medium-range atomic structures of network former and modifier ions are in good agreement with experimental results and simulations of similar glasses. It was found that increasing NMO/Al ratio increases the network modifier coordination number with non-bridging oxygen sites and reduces the overall stability of the network structure. The fraction of non-bridging oxygen sites in the vicinity of Gd3+ ions increases considerably with decreasing field strength and increasing concentration of the network modifier ions. These correlations could be confirmed even if the simulation results of alkaline earth aluminosilicate glasses are added to the analysis. In addition, the structure predictions generally indicate a low driving force for the clustering of Gd3+. Here, network modifier ions of large ionic radii reduce the probability of Gd–O–Gd contacts.
Effect of Fiber Content on the Mechanical Properties of Engineered Cementitious Composites with Recycled Fine Aggregate from Clay Brick
Authors: Cheng Zhanqi , Yan Wenhao , Sui Zhibo , Tang Jiyu , Yuan Chengfang , Chu Liusheng , Feng Hu
Published: June 2021

In this study, recycled fine aggregate (RFA), also known as recycled brick micro-powder (RBM), was used to completely replace quartz sand for the preparation of green, low-cost ecological engineered cementitious composites (ECO-ECC). RFA was used to replace ultrafine silica sand in the range of 0–100%. Firstly, the optimal replacement rate of RFA was determined, and the test results showed that the ECO-ECC prepared by fully replacing quartz sand with RFA as fine aggregate had strain hardening and multiple cracks, and the tensile strain of the specimens could reach 3%. Then the effects of fiber volume fraction and size effect on the mechanical properties of ECO-ECC were systematically investigated. The results showed that the fiber volume fraction has some influence on the mechanical properties of ECO-ECC. With the increase of fiber volume fraction, the ultimate deflection of the material keeps increasing up to 44.87 mm and the ultimate strain up to 3.46%, with good ductility and toughness. In addition, the compressive strength of the material has a good size effect, and there is a good linear relationship between different specimen sizes and standard sizes. It provides a good basis for engineering applications. Microscopic experimental results also showed that fibers play an important bridging role in the material, and the fiber pull-out and pull-break damage effects are significant.