bluuebunny/crossref_metadata_2025 huggingface dataset:
Maxillofacial osteosarcoma -- report of two cases with presentation of a two-staged reconstructive strategy and dental rehabilitation
Authors: Glajzer Jacek , Lutz Rainer , Nobis Christopher-Philipp , Olmos Manuel , Buchbender Mayte , Möst Tobias , Kesting Marco , Weber Manuel
Published: October 2023

Background: Maxillofacial osteosarcoma (MOS) is a rare disease, mostly
located to the mandible or maxilla. Surgical resection with wide free
margins represents the key intervention to achieve favorable prognosis.
MOS are particularly demanding to resect and surgically reconstruct
because of the numerous tissue types and functions included in this
location. Case reports: We introduce two patients with a highly
malignant maxillary OS treated by primary tumor resection and immediate
reconstruction with a microvascular soft tissue flap. After confirmation
of relapse-free tissue healing and sufficiently free resection margins,
osseous reconstruction was performed in a second operation by use of a
virtually planned microvascular Fibula Flap. Both patients received
implant-supported dental rehabilitation and show relapse-free for seven
and three years, respectively. Conclusions: Combination of radical tumor
resection, primary soft tissue reconstruction and secondary bone
reconstruction allows high oncologic safety and optimal conditions for a
thoroughly planned osseous as well as dental rehabilitation.
D-allose Attenuates Pyroptosis of Neurons after Cerebral ischemia-reperfusion injury via Regulation of the Gal-3/NLRP3 Pathway
Authors: Fu Yihao , Luo Yao-Wen , Zhang Min , Gou Mao-Rong , Shi Xia-Qing , Zhang Lei , Fei Zhou , Gao Da-Kuan
Published: October 2023

Objective: Cerebral ischemia-reperfusion injury (CIRI) is a particularly
severe pathological condition that arises when blood is restored to an
injured area after cerebral ischemia. Neuronal cell death stands out as
the most severe detrimental outcome of CIRI. Therefore, it is critical
to explore neuroprotective strategies following CIRI. This study aimed
to assess the potential neuroprotective effects of D-allose in the
context of CIRI by targeting the Gal-3/NLRP3 pathway and reducing
neuronal cell death. Methods: In this study, we employed a middle
cerebral artery occlusion (MCAO) model that included pretreatment with
D-allose. Assessment of MCAO injury included behavioral analysis,
neurological function scoring, and triphenyl tetrazolium chloride (TTC)
staining. Apoptosis following CIRI and D-allose treatment was determined
using TUNEL. Furthermore, we examined the expression of pyroptosis
related molecules and Gal-3 using q-PCR, Western Blotting, and
immunofluorescence staining. Results: Behavioral analysis, neurological
function scoring and TTC staining, revealed that pretreatment with
D-allose alleviated MCAO-induced brain injury. Additionally, D-allose
treatment was associated with reduced expression of pyroptosis-related
molecules and Gal-3 following CIRI. In the MCAO+AAV-shGal-3 group,
wherein Gal-3 expression was down-regulated, the expression of
pyroptosis-related molecules was lower compared to the MCAO+NC group.
However, D-allose treatment did not further enhance this reduction.
Conclusions: These findings strongly indicate that D-allose might play a
neuroprotective role in CIRI by downregulating Gal-3 expression, thereby
inhibiting activation of the pyroptosis pathway.
Impact of Dynamic Phytoplankton Stoichiometry on Global Scale Patterns of Nutrient Limitation, Nitrogen Fixation, and Carbon Export
Authors: Hagstrom George I , Stock Charles A. A , Luo Jessica Y. , Levin Simon A
Published: October 2023

Phytoplankton stoichiometry modulates the interaction between carbon,
nitrogen and phosphorus cycles, yet most biogeochemical models represent
phytoplankton C:N:P as constants. This simplification has been linked to
Earth System Model (ESM) biases and potential misrepresentation of
biogeochemical responses to climate change. Here we integrate key
elements of the Adaptive Trait Optimization Model (ATOM) for
phytoplankton stoichiometry with the Carbon, Ocean Biogeochemistry and
Lower Trophics (COBALT) ocean biogeochemical model. Within a series of
global ocean-ice-ecosystem retrospective simulations, ATOM-COBALT
reproduced observations of particulate organic matter N:P, and compared
to static N:P, exhibited reduced phytoplankton P-limitation, enhanced
N-fixation, and increased low-latitude export, leading to improved
consistency with observations. Two mechanisms together drove these
patterns: the growth hypothesis and frugal P-utilization during
scarcity. The addition of translation compensation- differential
temperature dependencies of photosynthetic relative to biosynthetic
processes- led to relatively modest strengthening of N:P variations and
biogeochemical responses relative to growth-plus-frugality. Comparison
of the multi-mechanism model herein against frugality-only models
suggest that both can capture observed N:P patterns and produce
qualitatively similar biogeochemical effects. There are, however,
quantitative response differences and different responses across N:P
mechanisms are expected under climate change- with the growth rate
mechanism adding a distinct biogeochemical footprint in
highly-productive low-latitude regions. These results suggest that
variable phytoplankton N:P makes some biogeochemical processes resilient
to environmental changes, and support using dynamic N:P formulations
with the ocean biogeochemical component of next generation of ESMs.
Reforms in Ayurveda Education: Challenges & Roadblocks
Authors: Kembhavi Aakash
Published: October 2023

Throughout the ages, Ayurveda was taught in the “gurukula” system of education and was an oral tradition where the “shlokas” or verses were passed on to the generation of students along with the applied aspects in clinical practice. It was during the early part of the 20th century concerted efforts were made to revive traditional Ayurveda system. Many committees were set up by the Government of India to investigate various aspects of Ayurveda and its education across India and the recommendations of a couple of these committees were not altogether supportive of Ayurveda as such. Many types of council were established but the educational system could not be standardised and the syllabus that we have today seems based on the modern medical system rather than concentrating on the core philosophy and practice of Ayurveda. Ayurveda today has become a multi-billion-dollar industry with the entire world wanting a share of the pie of it’s: health and wellbeing sector, the herbal medicine sector, the spa and resort sector, medical tourism sector and the education sector. Education in Ayurveda is caught at the cross roads of increasing global demand and declining local standards. It is high time that the regulatory bodies and all the stakeholders take serious note of this and intensify their efforts to standardize the education in Ayurveda failing which the science will be brought into disrepute and hijacked by vested interests who will then stake claim on the ownership of Ayurveda. This paper discusses the challenges and roadblocks faced at the entry level, undergraduate level, the curriculum and the regulatory bodies in the present scenario in India and propose certain solutions for the same.
Heavy Metal Concentrations in Commonly Sold Onions (Allium Cepa) and Probable Health Risk Assessment
Authors: AS Chamon
Published: October 2023

In this current research, samples of domestic and imported onions were collected from wholesale markets in Dhaka, Bangladesh, and their heavy metal concentrations were measured. Several health issues could arise from eating onions, according to estimations. After being randomly selected, prepared, and analyzed, samples from onions were used to assess whether contaminants such as heavy metals were present using atomic absorption spectroscopy. The mean readings for chromium, copper, lead, and zinc in the native and imported onion samples ranged from 0.00 to 6.24., 4.78 to 21.61, 0.00 to 37.00, 31.75 to 70.16 mg kg-1, and from 0.00 to 17.93, 3.64 to 17.04, 0.00 to 26.00, 10.97 to 42.72 mg kg-1, respectively. For the majority of the samples of foreign onions, the ADI values of Pb were higher than the PMTDI. Most onion samples had Hazard Index values higher than 1, indicating a risk in the future to human health (carcinogenic) from these onions intake.
Burden of Infectious Diseases in North East India: A Mini-Review
Authors: A Jakharia
Published: October 2023

North East India, with its unique geographical and cultural characteristics, bears a significant burden of infectious diseases. This mini review provides an overview of the prevalent infectious diseases in the region, highlighting the highest disease burden and the most endemic diseases. Malaria emerges as a major public health concern, with frequent outbreaks and substantial morbidity and mortality. Dengue fever, tuberculosis, Japanese encephalitis, Chikungunya, rickettsia diseases, waterborne enteric infections, hepatitis, and HIV/AIDS are also prevalent in the region. Challenges such as rugged terrain, limited transportation infrastructure, limited healthcare infrastructure, inadequate diagnostics, socio-economic factors and sharing of international border with four neighboring countries etc hinder disease control efforts. Strengthening vector control, improving diagnostics, expanding healthcare access, and raising community awareness are crucial strategies for reducing the burden of infectious diseases. Surveillance and research efforts are needed to enhance understanding and control of these diseases. Febrile illness like Scrub typhus stands out as the most endemic disease in the hilly regions, characterized by high prevalence, associated morbidity and mortality, and a lack of knowledge about its epidemiology and impact. Active surveillance is crucial to better understand the burden and distribution of the disease and address the challenges in the region.
Analysis of the influence of uneven settlement on the existing shield tunnel lining
Authors: Xiao Z. , Zhou H. , Wang J.
Published: October 2023

The transverse deformation of the tunnel under various loads is unavoidable with the long-term operation of the subway, and the problem of uneven settlement is gradually highlighted. A three-dimensional of tunnel lining model is established in ABAQUS to simulate the uneven settlement and transverse deformation on the safety performance, in which the deformation, internal force, and damage are further analyzed. Based on the simulation, safe settlement values for the shield tunnel with different level of existing transverse deformations (L) are suggested. Because the internal force and damage are not only related to the settlement value (∆) but also to the length of the tunnel where the settlement occurs, the ratio of the settlement value (∆) to the corresponding length (L) of the shield tunnel ∆/L which is called the uneven settlement coefficient is proposed as an index. The uneven settlement coefficient ∆/L is given for different transverse deformations to extend the applicability of the safe settlement values, which provides theoretical support for on-site monitoring and tunnel maintenance to some extent.
Pengukuran waktu standar proses kerja mesin bandsaw dan cross cut untuk perencanaan dan evaluasi pemenuhan pesanan
Authors: Wiranata F Edwin , Simarmata Claudia Fremtama Br , Halim Lenny
Published: October 2023

Industri furnitur terus berinovasi demi menghasilkan produk terbaik, dengan preferensi pembeli yang berhubungan dengan fungsi, kualitas, dan desain. Untuk meningkatkan produktivitas, perusahaan perlu mengoptimalkan waktu siklus mesin dan reformulasi durasi waktu produksi. Lead time perlu dioptimasi untuk memastikan pemenuhan pesanan sampai transaksi selesai tepat pada waktunya. Dalam pengukuran produktivitas, waktu standar sangat penting untuk menetapkan target produksi, budget, estimasi biaya produk, kebutuhan mesin, dan penentuan upah standar operator. Perusahaan pada bidang garden furniture perlu melakukan perhitungan waktu standar pada proses produksinya, khususnya pada proses pembahanan RST (Raw Sawn Timber), untuk mencapai target produksi yang tepat waktu dan menghindari potensi kerugian. Analisis produktivitas pada area produksi bagian pembahanan RST dilakukan dengan menghitung waktu standar mesin bandsaw dan mesin cross cut atau radial arm saw. Penelitian dimulai dengan melakukan pengukuran motion study, melakukan uji keseragaman dan kecukupan data, dan melakukan perhitungan waktu normal serta waktu standar untuk menentukan durasi waktu yang diperlukan dalam setiap tahapan produksi. Hasil time study dan perhitungan waktu standar pada 18 elemen kerja menunjukkan waktu standar pada proses pembahanan RST adalah 4,92 menit atau setara dengan 12 unit/jam, sehingga secara ideal perusahaan dapat menghasilkan produk kayu sebanyak 88 unit/hari.
Perencanaan konektivitas rute pengangkutan umum
Authors: Pradipta Antonius Romi Andika , Kadang Bella Aresta , Widiprasetyo Cornelius Angga , Hadisantono Hadisantono  , Dewa Parama Kartika
Published: October 2023

Berbagai moda transportasi umum telah tersedia bagi masyarakat di kota-kota besar di Indonesia. Namun angkutan umum tersebut belum menjadi opsi utama bagi kebanyakan warga masyarakat karena dianggap tidak efisien dari sisi waktu dan mobilitas yang tidak fleksibel. Oleh karena itu diperlukan sebuah sistem informasi terkoneksi transportasi umum yang dapat memberikan informasi mengenai jadwal dan biaya yang harus dikeluarkan. Sistem informasi tersebut diharapkan dapat menghubungkan semua moda transportasi umum yang ada. Langkah awal dari penelitian ini ialah mempelajari lebih lanjut mengenai transportasi umum yang ada di Indonesia khususnya di kota besar seperti kota Jakarta. Aplikasi sistem konektivitas rute transportasi yang direncanakan dibangun dengan gabungan teknologi basis data, data scrapping dan Geographic Information System. Aplikasi sistem konektivitas ini dibangun berbasis mobile agar dapat memudahkan pengguna mengaksesnya di mana saja dan kapan saja melalui smartphone mereka. Dengan demikian maka permasalahan transportasi umum yang tidak bisa menjangkau tempat asal dan tempat tujuan secara lengkap dapat teratasi.
Desain perbaikan sistem pelayanan berdasarkan voice of customer dengan metode TRIZ
Authors: Bumi Ignasia Talenta , Daryanto Yosef
Published: October 2023

Perbaikan kualitas layanan memerlukan perencanaan yang baik dengan kerangka kerja serta metode perancangan yang tepat. Penelitian studi kasus ini dilakukan pada sebuah jasa digital printing untuk mengurangi jumlah keluhan pelanggan perihal ketidaksesuaian pesanan yang diberikan. Tahapan perancangan mengikuti pendekatan design thinking process. Penelitian ini menggunakan data dari Google Review untuk mengidentifikasi voice of customer khususnya keluhan dan komentar negatif pelanggan, yang dikombinasikan dengan komplain yang disampaikan secara langsung ke karyawan. Selanjutnya, penelitian ini menggunakan metode TRIZ untuk mengembangkan ide solusi dan perbaikan. Metode TRIZ memberikan lima general solution yang membantu perancangan specific solution yaitu preliminary action, periodic action, parameter changes, curvature, dan strong oxidants. Implementasi atas perubahan platform pemberian review yaitu melalui media Instagram menunjukkan penurunan keluhan dari pelanggan. Hasil ini menunjukkan kerangka kerja yang diusulkan berupa identifikasi voice of customer dan perancangan dengan metode TRIZ dapat menghasilkan solusi terhadap keluhan pelanggan.
Theory of multiphysical similarity of hydrobionts
Authors: Nedostup Alexander Alekseevich , Razhev Alexey Olegovich , Bagrova Anastasiya Arturovna , Vasiliev Danil Evgenievich
Published: October 2023

In the course of studying the biomechanical characteristics of hydrobionts there appears a need to apply the theory of similarity of living objects. Along with the theory of similarity, the theory of dimensions is observed. There is considered the multiphysical similarity of hydrobionts of the same species, based on the theory of physical similarity of A. A. Nedostup. One of the tasks of studying the mechanics and hydrodynamics of living systems (hydrobionts) in the aquatic environment is to automate the collection of statistics with subsequent visualization of the characteristics of hydrobionts using augmented reality technologies. Based on the similarity theory, the rules of physical similarity have been developed, similarity criteria have been obtained with respect to geometric, mechanical, hydroacoustic, hydrodynamic, thermodynamic, and optical characteristics of hydrobionts. An important component of similarity is to preserve the physical nature of the original phenomena in the model. Based on the scale of the multiphysical similarity of hydrobionts, the criteria for the similarity of hydrobionts are determined. There is considered the solution of the problems of describing the biomechanics of hydrobionts in recirculation aquaculture systems, where only one species of hydrobionts is grown at the same time. The importance of studies of biomechanics of aquatic organisms in certain habitat conditions, in our case in an artificial enclosed space, with artificial lighting, feeding, cleaning system, etc., is explained by the need to increase fish productivity and environmental friendliness of fish farming, which requires automation of the growing process. Automation tasks require a preliminary mathematical description of processes in order to build simulation models. In turn, for a mathematical description of the growth process of a growing object, it is necessary to derive mathematical dependencies linking the target characteristics of the hydrobionts with the initial data of breeding conditions and a set of characterizing parameters of the object itself, including behavioral ones.
Optimization of the cryoprotector composition for the preservation of African catfish reproductive cells
Authors: Firsova Angelina Valerievna , Polovinkina Mariya Alexandrovna , Osipova Victoria Pavlovna , Ponomareva Elena Nikolaevna
Published: October 2023

The article presents a study on the selection of the optimal composition of the protective medium for cryopres-ervation of the reproductive cells of male African catfish. Glycerol, dimethyl sulfoxide (DMSO) at concentrations of 3, 5 and 10% were studied as the main cryoprotective additives. The influence of these compounds on the quality indicators of catfish sperm (the percentage and time of sperm movement after activation), the level of sperm lipid peroxidation, and the activity of the antioxidant enzyme catalase before and after the cryopreservation process was assessed. A decrease in fish breeding indicators of the quality of African catfish sperm (the proportion of living cells, motility time) was established when DMSO was added to the basic cryomedium. The greatest decrease in the percentage of sperm motility before freezing is observed when DMSO is added at a concentration of 10%. A dose-dependent effect of a decrease in sperm activity after freezing was noted with an increase in the addition of DMSO to the cryogenic medium from 3 to 10%. It has been shown that 3% glycerol in a cryogenic medium does not contribute to the preservation of cells during freezing, cryodamage caused by the formation of ice crystals leads to a significant decrease in the motility of catfish sperm. The best indicators of sperm quality were obtained when using glycerol, the most effective concentration is 5% (40% of mobile reproductive cells within 53 s). The addition of 5% glycerol to the cryomedium contributes to the greatest decrease in the level of peroxidation of sperm lipids and an increase in catalase activity, which is fully consistent with the results on sperm motility. The calculated correlation coefficients confirm the dependence of the reproductive qualities of gametes on the antioxidant status of cells. The results indicate the importance of using antioxidants as cryoprotective additives to improve the quality of African catfish sperm breeding and indicate the need for more research to evaluate the effect of adding new potentially effective and safe antioxidants as cryoprotective additives.
Türkiye'de Sanayileşme, CO2 Emisyonu, Ekonomik Büyüme ve Tarımsal Üretim İlişkisi: Ampirik Bir Uygulama
Authors: ÖZBAY Ülkü
Published: October 2023

Amaç: Bu çalışmanın amacı, 1994-2019 dönemi için Türkiye’de sanayileşme, ekonomik büyüme ve sera gazı emisyonları ile tarımsal üretim arasındaki kısa ve uzun vadeli ilişkiyi incelemektir.
Tasarım/Metodoloji /Yaklaşım: Sanayileşme, ekonomik büyüme ve sera gazı emisyonlarının tarımsal üretim ile ilişkisi ARDL sınır testi yardımıyla analiz edilmiştir.
Bulgular: Bulgu sonuçları, tarımsal üretim, sanayileşme, ekonomik büyüme ve sera gazı emisyonu değişkenleri arasında eşbütünleşme ilişkisi olduğunu göstermektedir. Kısa dönemde tarımsal üretimi; sanayileşme negatif yönde, ekonomik büyüme ve sera gazı emisyonu pozitif yönde etkilemektedir. Uzun dönemde, sanayileşmenin, ekonomik büyümenin ve sera gazı emisyonlarının tarımsal üretim üzerindeki etkisi istatistiki olarak anlamlı ve pozitiftir.
Özgünlük/Değer: Literatürde, Türkiye'de özelinde tarımsal üretim ile sanayileşme, ekonomik büyüme ve sera gazı emisyonları değişkenleri ile eşbütünleşme ilişkisini ele alan çalışma oldukça sınırlıdır. Ayrıca çalışmaların çoğunda tarımsal üretimi temsilen; tarımsal verimlilik, tarımsal gelir, tarımsal katma değer vb. değişkenler kullanılmaktadır. Bu çalışmada ise konuya ilişkin yapılmış diğer çalışmalardan farklı olarak tarımsal üretimi temsilen tarımsal üretim indeksi kullanılmıştır. Bu bağlamda çalışma bu alanda boşluğu doldurarak literatüre katkı sağlayacaktır.
Proposição de diretrizes para a política de gestão de resíduos sólidos de uma universidade pública brasileira
Authors: Bagatini Marotti Ana Cristina , Diniz Santiago Cristine , Nunes de Sousa Isabel Cristina , Aleixo e Silva Mendelson , Sanches Roberta , Pugliesi Erica
Published: October 2023

Neste artigo são propostas diretrizes para subsidiar uma política de gestão de resíduos sólidos em uma instituição de ensino superior (IES) brasileira, a partir de uma revisão bibliográfica sistemática (RBS). Identificou-se que a temática ainda é pouco explorada em publicações científicas, havendo um número reduzido de trabalhos sobre política de resíduos em instituições de ensino superior. A partir da leitura dos 19 artigos selecionados na RBS, foram propostas 19 diretrizes para uma política de resíduos sólidos universitária, abrangendo campos transversais como comunicação, educação ambiental e práticas sustentáveis. O embasamento das diretrizes na literatura contribui para a transversalidade e abordagem sistêmica da gestão de resíduos em IES. As diretrizes podem contribuir para o refinamento das iniciativas já existentes na IES em questão, para sua articulação, ou ainda para a proposição de iniciativas que busquem aprimorar a gestão de resíduos sólidos vigente.
Old trap for a new mule: A study on the role of financial systems in escaping the middle-income trap
Authors: Banerjee Srijanie , Sinha Manish , Kacker Mrinalini
Published: October 2023

The middle-income trap has been in developmental discussions for the better part of the last decade since the inability of most Latin American countries to break out of it. There is renewed interest in the concept since the realisation that one of the biggest economies in the world, i.e., China could be caught in it. While there is abundant literature on the part that social infrastructure and human capital development plays, the effect of financial systems is relatively ignored. This paper seeks to fill this gap by understanding the role of financial system variables in escaping the middle-income trap. By taking a sample of thirteen countries and using two classification techniques—Naive Bayes and random forest, it is concluded that both bank-based measures and market-based measures have an impact on income levels. These results have strong implications on understanding how to break out of the trap for policymakers.
Effects of regional accessibility on productivity: An analysis based on composite indicators
Authors: Januário João Fragoso , Costa Álvaro , Cruz Carlos Oliveira , Sarmento Joaquim Miranda , Sousa Vítor Faria e
Published: October 2023

The relationship between transport infrastructure and accessibility has long stood as a central research area in regional and transport economics. Often invoked by governments to justify large public spending on infrastructure, the study of this relationship has led to conflicting arguments on the role that transport plays in productivity. This paper expands the existing body of knowledge by adopting a spatial analysis (with spillover effects) that considers the physical effects of investment in terms of accessibility (using distinct metrics). The authors have used the Portuguese experience at regional level over the last 30 years as a case study. The main conclusions are as follows: i) the choice of transport variables matters when explaining productivity, and more complex accessibility indicators are more correlated with; ii) it is important to account for spill-over effects; and iii) the evidence of granger causality is not widespread but depends on the regions.
miR-30c-2-3p suppresses the proliferation of human renal cell carcinoma cells by targeting TOP2A
Authors: Huang Xiaoyong , Jia Yuna , Shi Haiyan , Fan Haiyan , Sun Lingbo , Zhang Huahua , Wang Yanfeng , Chen Jie , Han Jiaqi , Wang Mingming , Du Juan , Zhang Jing
Published: October 2023

Background

The ambiguity of renal cell carcinoma (RCC) symptoms hinders early diagnosis, thereby contributing to high mortality rates. By attaching to the 3′-untranslated region (UTR) of the target gene, microRNAs (miRNAs) exert significant control over the expression of genes.

Objectives

To investigate the influence of miR-30c-2-3p and DNA topoisomerase II alpha (TOP2A) on RCC growth and the mechanisms underlying the regulation of its expression.

Methods

The expression of miRNA-30c-2-3p and TOP2A in RCC cells was examined using quantitative real-time polymerase chain reaction (qRT-PCR). MiR-30c-2-3p mimics, its inhibitors, and controls, as well as TOP2A short hairpin RNA (shRNA) and controls, were used to transfect the human RCC cell lines 786-O, Caki-1, and ACHN. Additionally, the roles of miRNA-30c-2-3p and TOP2A in the growth of RCC were evaluated using the cell counting kit (CCK)-8 test, colony formation assay, apoptosis analysis, and Western blotting. Meanwhile, binding of miRNA-30c-2-3p and TOP2A was verified using dual-luciferase reporter assays and Western blotting.

Results

miR-30c-2-p is underexpressed in RCC cells. Overexpression of miR-30c-2-p promotes apoptosis and inhibits proliferation of ACHN, Caki-1, and 786-O cells. miR-30c-2-3p targets TOP2A, which is elevated in RCC tissues and cells, whereas TOP2A silencing inhibits the proliferation ability of RCC cells. The miRNA-30c-2-3p inhibitor compromises TOP2A shRNA-induced apoptosis of RCC. RCC cells cotransfected with miRNA-30c-2-3p inhibitors and TOP2A shRNAs have a higher proliferation rate than those transfected with only TOP2A shRNAs.

Conclusions

Collectively, our results verify that miRNA-30c-2-3p has a tumor suppressor property. miRNA-30c-2-3p inhibits the proliferation of RCC through regulation of TOP2A. The data provide a viable therapeutic target for RCC.
Spatial assessment of nighttime anthropization in the Comoé National Park in Côte d’Ivoira (West Africa)
Authors: Sylla Gaoussou , Coulibaly Talnan Jean Honoré , Coulibaly Naga , Kouadio Koffi Claude Alain , Coulibaly Houebagnon Saint Jean Patrick , Cissé Souleymane , Sie Kambiré
Published: October 2023

Protected areas play a crucial role in preserving biological diversity, providing ecosystem services, and regulating hydroclimatic processes. However, the environmental balance of these areas is increasingly under threat due to rapid population growth, high demand for natural resources, and the effects of global warming. To address this, sustainable management of protected areas is essential. This study aims to develop a methodology for monitoring and assessing levels of nocturnal anthropogenic aggression in the Comoé National Park (CNP) in Côte d’Ivoire. By using geospatial data from the Day/Night Band of the Visible Infrared Imaging Radiometer Suite (VIIRS/DNB), the study characterizes the nocturnal anthropization of CNP through the use of several indices. First, light reflectance density is used to identify nighttime light emission foci. Second, the lighted area density index (LADI) is employed to understand the nature of nocturnal activities taking place within CNP, as indicated by artificial light at night (ALAN). Finally, the light intensity index (LII) is used to evaluate the degree of influence of nocturnal anthropogenic activities on biodiversity. The study also found important activities through LADI and observed a high level of light pollution in CNP. Ultimately, the findings of this study indicate that there is a significant level of nocturnal anthropization within CNP, highlighting the need for effective management and conservation efforts in the area.
PENYULUHAN MENGENAI KEBERLANJUTAN USAHA PERIKANAN TANGKAP SKALA KECIL BERDASARKAN ASPEK EKONOMI DI OHOI OHOIDERTAWUN KABUPATEN MALUKU TENGGARA
Authors: Picaulima S.M. , Notanubun J. , Kilmanun A.D.
Published: October 2023

Pengabdian kepada masyarakat yang dilakukan di Ohoi Ohoidertawun ini bertujuan untuk memberikan pemahaman terkait keberlanjutan usaha perikanan skala kecil berdasarkan status kelayakan ekonomi yang meliputi aspek finansiaal usaha dan investasi modal usaha, agar usaha perikanan skala kecil kedepan dapat berjalan dengan baik dan menguntungkan. Metode pengabdian adalah penyuluhan yang meliputi diskusi dan tanya jawab. Hasil yang diperoleh menunjukan bahwa penyuluhan yang dilakukan berhasil dengan baik. Peserta mitra nelayan kecil dan staf Pemerintahan Ohoi Ohoidertawun sangat antusias dalam mengikuti penyampaian materi penyuluhan yang disampaikan oleh tim pengabdi sehingga ketika diakukan evaluasi pada akhir kegiatan pertanyaan mampu dijawab oleh peserta dengan baik dan benar. Masalah yang dihadapi oleh nelayan mitra adalah pendapatan usaha mitra nelayan kecil sangat tergantung pada musim penangkapan sehingga usaha perikanan tangkap skala kecil dimasa depan sulit diprediksi. Status kelayakan usaha perikanan meliputi kelayakan finansial usaha dan kelayakan investasi usaha. Kegiatan ini berjalan dengan baik, lancar dan penuh interaksi yang baik antara tim pengabdi dan peserta, hasil dari kegiatan ini telah meningkatkan pemahaman mitra nelayan kecil mengenai keberlanjutan usaha perikanan tangkap skala kecil di Ohoi Ohoidertawun.

Kata kunci : Keberlanjutan, Nelayan kecil, Kelayakan usaha, Finansial usaha, Investasi usaha.
PENINGKATAN PRODUKSI JAMUR TIRAM DENGAN APLIKASI TEKNOLOGI TEPAT GUNA
Authors: Atmika I.K.A. , Suriadi I.G.A.K. , Budiana I.M.D. , Arda I.G.
Published: October 2023

UD Ayu Dewata Jamur adalah usaha pembudidaya jamur atau pembesaran messelium jamur tiram yang berlokasi di banjar Tegehe desa Batubulan-Gianyar. Produksi jamur tiram dikemas sederhana dengan kantong plastik ukuran 1 kg. Mitra pengabdian ini mempunyai permasalahan yang berkaitan dengan effisiensi dan produktifitas yang disebabkan oleh belum adanya sistem atau mekanisasi mempertahankan temperatur dan kelembaban ruang inkubasi messelium. Pengelola budi daya jamur tiram ini belum mempunyai ketrampilan maupun latar belakang pendidikan yang masih rendah. Tujuan dan luaran dari kegiatan ini adalah menghasilkan mekanisasi proses pengatur suhu dan kelembaban ruangan pembesaran messelium, yang dilengkapi dengan spray air atau kabut secara semi otomotis. Disamping itu tim juga memberikan pengetahuan tentang manajemen, keselamatan kerja dan pengendalian kualitas produk dalam kaitannya dengan penerapan mekanisasi ini. Metode yang ditawarkan pada program ini adalah merancang dan memasang mekanisasi spray semi otomatis yang dilengkapi juga dengan indikator temperatur dan kelembaban udara. Kegiatan di mitra dilaksanakan tanggal 25 Agustus 2019, 30 Agustus 2019, dan 2 September 2019 bertempat budidaya jamur tiram UD Ayu Dewata Jamur di desa Batubulan kecamatan Sukawati Gianyar-Bali. Kegiatan awal dimulai dengan membersihkan dan menyiapkan tempat pemasangan instalasi mekanisasi spray air atau kabut. Berikutnya adalah pemasangan dan uji coba sistem spraying air atau kabut. Kegiatan pemantauan dilakukan tanggal 2 Oktober 2019, dan didapat jamur tiram tumbuh dengan sangat baik.

Kata kunci : messelium, jamur tiram, mekanisasi, indikator temperatur, semi otomatis
BRANDING RINTISAN DESA WISATA “JATISARI EDUPARK” DALAM MENINGKATKAN DAYA TARIK PENGUNJUNG
Authors: Riptanti E.W. , Widyamurti N. , Suherlan Y. , Irianto H. , Widiyanti E. , Santoso R.E.
Published: October 2023

Desa Jatisari merupakan salah satu daerah pengembangan budidaya porang di Kabupaten Wonogiri. Umbi porang menjadi salah satu komoditas ekspor Indonesia. Melihat potensi dan peluang tersebut, Pemerintah Desa Jatisari merintis desa wisata di Dusun Tanduran. Lahan milik Pemerintahan Desa digunakan untuk perluasan budidaya dan sebagai pusat edukasi porang. Namun sayangnya, pemerintah desa belum memiliki branding destinasi desa wisata. Tujuan kegiatan adalah membangun branding rintisan desa wisata Jatisari yang mempunyai kekhasan tertentu. Metode pelaksanaan menggunakan Participatory Rural Appraisal (PRA) dimana masyarakat terlibat secara aktif dalam perancangan branding yang dimulai dari perancangan logo, identitas visual, sampai diaplikasikan pada area destinasi wisata. Kegiatan ini disinergikan dengan program kerja pemerintah desa. Hasil kegiatan diperoleh branding rintisan desa wisata yang disepakati adalah “Jatisari Edupark”. Jatisari Edupark menyuguhkan kegiatan belajar budidaya porang, budidaya padi, wisata agro, outbound edukasi dan wisata kuliner. Desain logo terdiri dari unsur saung, sawah, gunung dan tanaman porang dengan dipadukan warna yang selaras. Desain logo sudah diaplikasikan pada flier pembukaan “Jatisari Edupark” dan tiket masuk. Branding ini dapat meningkatkan animo wisatawan dalam mengunjungi Jatisari Edupark. Kata Kunci: agrowisata, porang, PRA, logo, potensi
SCREENING KELUHAN MUSKULOSKELETAL, PELAYANAN KESEHATAN FISIOTERAPI, PELATIHAN STRETCHING DAN SOSIALISASI FAKTOR RISIKO LOW BACK PAIN DAN POSISI KERJA ERGONOMIS PADA PETANI
Authors: Saraswati P.A.S. , Antari N.K.A.J. , Wibawa A. , Thanaya S.A. , Nugraha M.H.S.
Published: October 2023

Penyakit akibat kerja (PAK) merupakan penyakit yang mempunyai penyebab yang spesifik atau memiliki hubungan yang kuat dengan pekerjaan, alat kerja, bahan, proses maupun lingkungan kerja. Berdasarkan analisis situasi, maka program yang diprioritaskan adalah membantu petani untuk dapat bekerja dengan risiko penyakit muskuloskeletal akibat kerja seminimal mungkin sehingga tidak mengganggu produktivitas dan menyebabkan disabilitas. Program yang diprioritaskan meliputi: screening keluhan muskuloskletal, pelatihan stretching masal, dan pelayanan fisioterapi, serta edukasi mengenai tata laksanan nyeri yang dapat dilakukan petani di rumah secara mandiri. Berdasarkan hasil pengabdian, terlihat bahwa rerata umur petani subak adalah 56 tahun dengan total lama kerja mencapai 16,5 tahun. Sementara dari segi nilai nordic body map, didapatkan rerata 30,6 dan masuk ke dalam kategori risiko rendah mengalami gangguan musculoskeletal. Kegiatan pengabdian ini berlangsung dengan baik dimana peserta memahami mengenai risiko gangguan musculoskeletal dan bagaimana teknik melakukan peregangan. Selain itu, telah terlaksana pula pelayanan fisioterapi berupa pemberian intervensi diberikan kepada petani yang mengalami nyeri punggung bawah, nyeri leher, tennis elbow, spasme otot di betis dan lengan. Pemberian intervensi fisioterapi dilakukan dengan memberikan elektroterapi, pendekatan manual terapi seperti massage, serta terapi latihan. Di akhir sesi, tim pengabdian juga melakukan edukasi mengenai tata laksana nyeri yang dapat dilakukan petani di rumah secara mandiri, serta sosialisasi mengenai low back pain dan posisi kerja yang ergonomis.

Kata kunci : ergonomis, muskuloskeletal, stretching, fisoterapi, petani
SOSIALISASI HUKUM BAGI MASYARAKAT MENGENAI PEMENUHAN KEWAJIBAN KREDIT SELAMA MASA PANDEMI COVID-19
Authors: D.Y. Utami P. , G.P. Yustiawan D. , A.S. Utari A. , T.L. Hadjon E.
Published: October 2023

Selama masa pandemi COVID-19, terdapat permasalahan hukum yang dialami masyarakat mengenai ketidaktahuan akan adanya program restrukturisasi kredit dari pemerintah guna menangani kredit bermasalah serta kurangnya pemahaman mengenai sifat force majeure relative dari pandemi COVID-19 yang tidak menghapuskan kewajiban kredit, melainkan hanya bersifat menangguhkan melalui keringanan-keringanan pada upaya restrukturisasi kredit. Kegiatan berlokasi di Desa Satra, Kabupaten Klungkung. Tujuan dari kegiatan pengabdian kepada masyarakat ini ialah untuk memberikan pemahaman bagi masyarakat Desa Satra yang memiliki kredit bermasalah selama masa pandemi COVID-19 agar tetap berusaha dalam menjalankan pembayaran kewajiban kredit pada lembaga perbankan. Mengingat terjadinya pandemi COVID-19 sangat mempengaruhi tingkat perekonomian masyarakat, kegiatan ini juga bertujuan untuk memberikan pemahaman kepada masyarakat Desa Satra bahwa selama masa pandemi COVID-19 pihak perbankan tidak akan serta merta melakukan eksekusi terhadap benda jaminan ketika terjadi kredit bermasalah, melainkan masyarakat dapat diberikan keringanan pembayaran melalui upaya restrukturisasi kredit. Pelaksanaan kegiatan pengabdian dilakukan dengan memberikan sosialisasi, diskusi serta tanya jawab dengan mendalam sehingga sasaran kegiatan pengabdian dapat tercapai dengan sangat baik. Hasil kegiatan ini menunjukkan bahwa kegiatan sangat efektif dilakukan, yang terbukti dari antusiasnya responden yang merupakan masyarakat umum, pengurus desa dan pengurus BUMDES di Desa Satra dalam menyimak pemaparan tim pengabdi.

Kata Kunci : Sosialisasi Hukum, Kredit Macet, Restrukturisasi, COVID-19.
Perbandingan ELM dan Double Exponential Smoothing Untuk Meramalkan PDRB Di Provinsi NTT
Authors: Toron Laura Liokelly , Setyawan Yudi , Pratiwi Noviana
Published: October 2023

Abstrak: Produk Domestik Regional Bruto merupakan jumlah total produk barang dan jasa yang dihasilkan unit produksi seluruh sektor perekonomian suatu daerah tertentu selama satu tahun. BPS NTT mencatat bahwa laju pertumbuhan ekonomi NTT tahun 2020 mengalami kontraksi sebesar -0,83% dari tahun sebelumnya 5,24%, sehingga penelitian ini bertujuan meramalkan PDRB NTT menggunakan metode ELM dan Double Exponential Smoothing dari Holt. ELM merupakan jaringan syaraf tiruan yang memiliki satu hidden layer yang diterapkan melalui proses training dan testing, kemudian melibatkan fungsi aktivasi sigmoid biner dan matriks Moore Penrose Pseudo Inverse untuk mendapatkan output weight yang digunakan untuk meramalkan. DES Holt merupakan metode peramalan yang memperhatikan plot data trend dan menggunakan dua parameter dalam perhitungannya. Hasil penelitian peramalan menunjukkan bahwa metode ELM dengan proporsi 80%:20% adalah metode terbaik dalam meramalkan PDRB NTT. Metode ELM menghasilkan nilai PDRB triwulan pada tahun 2021, yaitu sebesar 17493.19754, 18154.80753, 18712.02153, dan 18822.97416 (miliar rupiah) dengan 4 neuron input, 12 neuron hidden layer, 1 neuron output dan diperoleh nilai MAPE sebesar 0,7968% yang lebih kecil daripada DES Holt.
Perbandingan Metode Moving Average dan Single Exponential Smoothing Pada Peramalan Inflasi Kota Purwokerto
Authors: Chandra Novita Eka , Rohmaniah Siti Alfiatur
Published: October 2023

The rate of inflation that goes up and down can lead to economic instability. To overcome this, it is necessary to forecast the value of inflation in the coming year, so that the government can make decisions in regulating economic policy. The data used in this research is the inflation data for the city of Purwokerto for 6 years. Based on the data plot, it can be seen that the data can be predicted using the Moving Average and Single Exponential Smoothing methods. The purpose of this study is to compare the two forecasting methods and determine the best method based on the error size value. From the analysis, it is found that the Single Exponential Smoothing method is better used in forecasting than the Moving Average method, because the MAPE, MSD and MAD values ??are smaller. The results of inflation forecasting for the city of Purwokerto in 2018 rose by 0.44 percent.
Optimalisasi Keuntungan Menggunakan Metode Branch And Bound Pada Produksi Spring Bed
Authors: Dali Daryana , Lesnussa Yopi Andry , Ilwaru Venn Yan Ishak
Published: October 2023

PT Satelit Maluku is a company that produces spring beds with three types, namely 2in1, ordinary spring beds and single beds. Every company established aims to get big profits as well as PT Satelit Maluku. To obtain large profits, companies need to make strategies so that each available material can be allocated optimally and appropriately. The purpose of this research is PT Satelit Maluku can optimize the profit of spring bed production by using the Branch and Bound and QM for Windows V5 methods. From the results of calculations using the Branch and Bound method and QM for windows V5, the optimal profit is Rp. 19,775,000 with a lot of production of spring bed type 2in1 is 0 (not producing), ordinary spring bed is 26 pieces and single bed is 3 pieces.
Illocutionary Acts in Final Destination 5 Movie
Authors: Liestya Devi Gusti Ayu Arlinda , Pratiwi Desak Putu Eka
Published: October 2023

Illocutionary act is one of three basic concepts of speech act. Illocutionary act is a type of speech act that has a purpose behind the utterance. The utterance is not only basic information, it also contained statements, commands, commitments, expressions, and declare something. This article aims to analyze the types and the meaning of illocutionary act used in Final Destination 5 movie. The writer interested in analyzing Final Destination 5 movie since the movie has a good review and provided the data. The data were collected by observation method. The collected data were analyzed by qualitative method using theory proposed by Searle (1979) to identify the types of illocutionary act. Seven Types of Meaning theory by Leech (1981) to find the meaning of illocutionary act and supported by Context of Situation theory by Halliday and Hassan (1985). The finding shows that there are five types of illocutionary acts that found in Final Destination 5 movie, there are 23,07% assertives, 30,07% directives, 15,3% commissives, 26,9% expressives, and 3,84% declarations.
The Women’s Language Features in Crazy Rich Asians Movie
Authors: Wardhana Evellyn , Suastra I Made , Seri Malini Ni Luh Nyoman
Published: October 2023

This study aims to identify the women’s language features in Crazy Rich Asians movie. The women’s language features are identified using the theory of language and woman’s place proposed by Lakoff (2004). This is a qualitative study that used documentation and observation checklist method in collecting the data. In analyzing the data, this study applied the content analysis method. The result of the analysis was presented descriptively using the informal method. The analysis comes to the conclusion that the Crazy Rich Asian movie contains all women’s language features. There are ten women’s language features, namely lexical hedges, tag questions, rising intonation, empty adjectives, precise color terms, intensifiers, hypercorrect grammar, superpolite forms, avoidance of swearwords, and emphatic stress.
A Comparative Study of Indonesian and Japanese Classifiers
Authors: Astariani Sandra
Published: October 2023

Abstract

            Classifiers belong to open class noun. All languages are naturally occupied with classifiers, yet the usage is various depending on how the language treats them. Japanese language, as an obligatory-classifier language, makes the classifiers compulsory, in contrast with an optional-classifier language, Indonesian language. Despite this, Japanese and Indonesian languages treat the classifiers syntactically and semantically similar. This article aims at revealing, both the semantic and syntactic differences and similarities between Japanese and Indonesian classifiers. The analysis shows that in terms of structure, Japanese and Indonesian classifiers are similar; however, each language demonstrates difference in classifier use. Japanese language has nineteen frequently used classifiers including two types which can replace others. They can change their form by fusing with its numeral adjective as in hitori (ichi-nin), ippiki (ichi-hiki), without affecting the whole meaning of the noun phrase. Indonesian classifiers cover of twenty-two optional types. Classifiers are often omitted in spoken form to avoid formality and some of them can also change their form by adding se- prior to the numeral adjective to indicate “one object” as in sebatang rokok.
ГРУЕН ЕФЕКАТ
Authors: Весовић Ивана , Атанацковић-Јеличић Јелена
Published: October 2023

Груен ефекат је психофизички концепт који суптилно лежи у искуствима потрошача у супермаркетима и тржним центрима. Проблематика рада посвећена је социо-просторном феномену у архитектонском пројектовању и урбанистичком планирању, како утицајним тако и злоупотребљеним. Указивањем на просторне и временске варијације феномена у различитим контекстима проблематизује се универзалност процеса, односно указује се на елементе неопходне за дефинисање Груен ефекта.
JEDNOPORODIČNA KUĆA U TOKIJU
Authors: Đilas Milan
Published: October 2023

Predmet istraživanja jeste stanovanje u Japanu i načini izrade kuća. Cilj projekta jeste izrada projekta na zadatoj lokaciji. Integracija zelenila u sam  arhitektonski koncept je bitan zadatak rada.
BUTIK HOTEL U DVORCU DUNĐERSKI U ČELAREVU
Authors: Đorđević Ivan
Published: October 2023

Dizajn enterijera butik hotela u dvorcu Dunđerski u Čelarevu, inspirisan švedskim modnim brendom Acne Studios, jeste projekat koji kombinuje istorijski karakter dvorca sa modernim i skandinavskim elementima. Enterijer butik hotela karakteriše minima­listički stil i funkcionalni dizajn sa jednostavnim linijama i neutralnim bojama.
IDEJNO REŠENJE ZA PROJEKAT BOTANIČKE BAŠTE U LOS ANĐELESU
Authors: Stojanović Helena
Published: October 2023

Ovaj projekat predstavlja rešenje moderne botaničke bašte koja se temelji na ideji velikog napretka i uticaju ekoloških promena na arhitekturu.
PRIMENA VEŠTAČKE INTELIGENCIJE U ARHITEKTONSKOM PROJEKTOVANJU PLANETARIJUMA
Authors: Grbić Igor
Published: October 2023

Glavna ideja je bila da se uključi upotreba veštačke inteligencije kao pomoć pri arhitektonskom projektovanju planetarijuma. Nova tehnologija nije tu da zameni arhitekte već da im služi kao dodatni alat koji će voditi ka kvalitetnijoj arhitekturi. Takođe, bitnu ulogu veštačka inteligencija imala je u stvaranju i kreiranju imaginarnih scena koje ilustruju estetiku i način upotrebe planetarijuma.
RAZVOJ APLIKACIJE ZA REŠAVANJE PROBLEMA MANUELNOG RAČUNANjA POTROŠNjE VAZDUHA POD PRITISKOM
Authors: Lazić Dejan
Published: October 2023

U ovom radu je predstavljen proces razvoja aplikacije pomoću kojeg se automatski obrađuju podaci dobijeni sa mernog uređaja „AirBox“. Automatskim računanjem ukupne potrošnju vazduha pod pritiskom u izabranom intervalu vremena rešen je problem dosadašnjeg, manulenog  načina računanja ukupne potrošnje vazduha pod pritiskom. Podaci sa mernog uređaja „AirBox“, koji se koristio za potrebe ovog rada, se konvertuju u CSV tip fajla i uvoze u razvijenu aplikaciju. Izvršena je validacija dobijenih rezultata.
ПРИМЕНА АНАЛИЗЕ ФИНАНСИЈСКИХ ИЗВЕШТАЈА У КОРПОРАТИВНОМ УПРАВЉАЊУ
Authors: Милић Лазар , Кузмановић Богдан
Published: October 2023

У раду је представљен значај приме­на анализе финансијског извештавања у корпоративном управљању. Рад је посвећен корпоративном управљању, а такође се бави начелима и процесом управљања ризи­ком, и дат је осврт на стратегију управљања ризиком и интерну ревизију. Практични део рада је посвећен ана­лизи финансијских извештаја компаније НИС, који су од пресудног значаја приликом доношења одлука од стране менаџмента за управљање организацијом.
UNAPREĐENJE PROIZVODNOG PROCESA PREDUZEĆA „LEAR CORPORATION“ PRIMENOM „VALUE STREAM MAPPING“ METODE
Authors: Kovačević Katarina
Published: October 2023

Ovaj rad prikazuje praktičnu primenu Lean alata „Value stream mapping“ u proizvodnom sistemu za proizvodnju automobilskih delova, kako bi se isti optimizovao.