bluuebunny/crossref_metadata_2025 huggingface dataset:
FINANCIAL DIAGNOSTICS OF ENTERPRISES OF UKRAINE: EXTRAPOLATION IN BUSINESS-ANALYSIS
Authors:   Robert Elvorti Economics and Technology Institute, Tkachenko Iryna , Frunza Svitlana ,   Robert Elvorti Economics and Technology Institute, Havrysh Halyna ,   Robert Elvorti Economics and Technology Institute
Published: May 2024

The article evaluates the financial performance of domestic enterprises, sources of financing of assets and efficiency of their placement, and the main parameters of the implementation of the payment discipline. The trends of exponential smoothing of the growth rates of accounts payable and receivable in GDP for 2024–2025 are built It is noted that the low provision of enterprises with financial resources is accompanied by an unsatisfactory level of their use, and the problems of payment discipline of enterprises, including industrial ones, are confirmed by the growth of the financial risk ratio. Conducting and developing domestic business in the face of martial law challenges sets new requirements for ensuring its sustainability and sustainable development. Particularly relevant in the current environment is the ability to respond quickly to external changes, continuously adapt to modern business conditions, solve financial support problems, increase the efficiency of using available financial resources and diversify funding sources. Solving these issues is one of the main conditions for the survival of enterprises, determining the prospects for their sustainable and balanced development, the management strategy of which should be implemented taking into account the requirements of ensuring economic security, diagnostics and continuous monitoring of implementation. the results of financial diagnostics of the state of domestic enterprises and their extrapolation into business analytics are the basis for making effective strategic financial decisions. The article highlights the need to extrapolate the results of diagnostics of financial security, increase the efficiency of financial resources, and ensure the financial security of Ukrainian enterprises into the processes of business analysis. We believe that insufficient attention has been paid to extrapolating the results of financial condition diagnostics, ensuring the financial security of enterprises, modeling their development prospects, and creating an attractive investment climate into business analysis. These issues are especially relevant for the organization of management of businesses operating under martial law and bringing our Victory closer.
Dealing With Academic Conflicts In The Classroom
Authors: Reid Donald
Published: May 2024

Writing in 1999, the American anthropologist David Stoll challenged several important elements in Guatemalan Nobel Prize winner Rigoberta Menchu' s I, Rigoberta Menchu, a text assigned in courses in many disciplines in American colleges. 1 The controversy Stoll sparked encouraged a number of instructors to drop I, Rigoberta Menchu from their reading lists. Yet it is the controversial nature of this work which makes it suitable for my 150-student introductory course, "The World Since 1945," which meets a "cultural diversity" requirement for students at all class levels. My goal in assigning a troubling and troubled text such as I, Rigoberta Menchu in this course is to open up a dialogue. I, Rigoberta Menchu questions students, while encouraging them to pose and answer new questions, taking them to places where supporters and critics of the text (including the instructor) might never have gone.
In order to provide a context for students reading I, Rigoberta Menchu, I begin with a lecture on Guatemala in the twentieth century. I want students to relate the historical narrative I present, in which the 1954 coup is a central event, to Menchu's historical narrative, in which both the coup and the United States are largely absent. (This is not a course in Central American history in which students' immersion in the subject would allow them to explore in greater depth the context in which Menchu lived and wrote.) I divide the readings into three parts. First I have students read I, Rigoberta Menchu, without introducing Stoll's analyses, because I want students to develop their own readings of her text. Then we tum to Stoll's study and the debate it has generated, and conclude with passages from Menchu's later Crossing Borders.
Kyvig, Daily Life In The United States, 1920-1940 - How Americans Lived Through The 'Roaring Twenties' And The Great Depression
Authors: Butchart Ronald
Published: May 2024

Only rarely are we treated to a volume that serves equally well as a resource for lecture preparation and as a required text. Most books that we keep on a handy shelf for quick reference are, too narrow and technical for undergraduate or secondary school students; most texts that we choose for classroom use are too general and derivative to bother with for reference. David Kyvig's new volume fills both bills for the cultural and social history of the 1920s and 1930s. Daily Life in the United States, 1920-1940 is virtually encyclopedic in its coverage of a vast array of topics, yet it manages to be readable and engaging. Kyvig ranges across changes in family demographics, religion, education, media (especially radio and the movies), leisure pursuits, courtship, labor, immigration, transportation, economics, and fashion (right down to women's underwear), paying careful attention to the differential experiences of social change across region, race, class, and gender. For introductory courses in United States cultural history, or as a supplementary text in survey courses, Daily Life is accessible and absorbing without talking down to students; for teachers and scholars, Kyvig provides an excellent synthesis of the last three decades of historical scholarship in social and cultural history, with well-chosen data and vignettes to illustrate findings and trends.
Brose, A History Of Europe In The Twentieth Century
Authors: Whisenhunt William
Published: May 2024

Eric Dorn Brose has written a wonderful new survey of the tumultuous history of Europe in the twentieth century. This book is designed as a textbook for a course on twentieth-century European history. While the book is organized chronologically, the true strength of the book revolves around the five themes that reoccur throughout the text.
Global Muckraking
Authors: Hussey Michael
Published: May 2024

On October 9, 1907, Robert Bacon, Acting Secretary of State, wrote to the United States ambassador in London, Whitelaw Reid, that satirical postcards regarding the U.S. meat industry were circulating in South Africa. Originally published in England, these cards depict the plight of a rooming house lodger attempting to eat various samples of "Chicago tinned meat." In one scene, a scrawny fowl emerging from a can of potted chicken cries out, "Was anyone asking for me?" In another, the unfortunate lodger turns away and holds his nose as a can of "awful, rotten, [and] putrid" ham and tongue is opened.
R.L. Graycroft, Cape Town general manager of the meatpacking firm Armour and Company, complained to the U.S. consul in that city that the postcards were libelous to "Chicago and damaging to our business." British colonial authorities had rejected Graycroft's allegation of libel since the cards never mentioned a particular meatpacking firm.
Freeberg, Democracy's Prisoner - Eugene V. Debs, The Great War And The Right To Dissent
Authors: Briley Ron
Published: May 2024

Any citizen, student, or teacher seeking to make sense of the post 9/11 world would do well to consult this volume on the imprisonment of perennial Socialist Party Presidential candidate Eugene V. Debs for his dissent to American participation in the First World War. Relying upon extensive archival research and an exhaustive reading of early twentieth-century periodicals, Ernest Freeberg, Associate Professor of History at the University of Tennessee, constructs a well-written narrative of efforts on behalf of civil libertarians and free speech advocates to obtain the release of Debs and other political prisoners.
Jackson, Becoming King - Martin Luther King Jr. And The Making Of A National Leader
Authors: Kirby John
Published: May 2024

Much has been written about the Montgomery bus boycott of 1955-56 and of the life and times of Martin Luther King, Jr. Yet Troy Jackson's fine book offers some fresh perspectives on both Montgomery and the impact it had on King's subsequent leadership in the civil rights struggles of the 1960s. Jackson brings to his story of King and Montgomery credentials both as a professional historian and a clergyman. At the present, he is senior pastor at University Christian Church in Cincinnati. The basic theme of Becoming King is that racial and social conditions existing in Montgomery at the time of Rosa Parks's famous arrest in December 1955 played a crucial role in shaping King's social and religious philosophy of racial justice after 1960, thus helping define his leadership of the national civil rights movement until his death in 1968.
Pasolini Overseas: His Reception in Canada
Authors: Ferraro Alessandra
Published: May 2024

After briefly tracing the history of Pier Paolo Pasolini’s travels in the Americas through the photographs that immortalize him, I focus my attention on the reception of his work and thought in Canada. I con­sider it significant especially in the context of gay, queer, and LGBTQ+ culture and among Italian-Canadian intellectuals. In the Canadian context, characterized by linguistic and cultural plurality, writers and essayists of Italian descent translate Pasolini’s works, absorb his lessons, and draw on his thought to explore mainly identity-related issues. In the queer artistic milieu, it will be Pasolini’s biographical journey in par­ticular that attracts the attention of intellectuals and performers who, by manipulating his works and images, transform him into an icon of the different.
Emapalumab as salvage therapy for adults with malignancy-associated hemophagocytic lymphohistiocytosis
Authors: Johnson William T. , Epstein-Peterson Zachary D. , Ganesan Nivetha , Pak Timothy , Chang Tiffany , Dao Phuong , Moskowitz Alison J. , Stuver Robert N. , Ghione Paola , Galasso Natasha , Khan Niloufer , Palomba M. Lia , Caron Philip C. , Kumar Anita , Tamari Roni , Lue Jennifer K. , Noy Ariela , Falchi Lorenzo , Intlekofer Andrew M. , Gyurkocza Boglarka , Perales Miguel-Angel , Scordo Michael , Herskovits A. Zara , Salles Gilles , Vardhana Santosha A. , Horwitz Steven M.
Published: May 2024

Not available.
Consideraciones sostenibles para el diseño de urbanizaciones cerradas en la ciudad de Cuenca
Authors: Cajamarca Dacto Karina Elizabeth , Briones Rodríguez Jonnathan Javier , Morales González Janeth Alexandra , Nieto Páez Erick Fabricio
Published: May 2024

Introducción: El estudio se enfoca en las urbanizaciones cerradas en Cuenca, Ecuador, que surgen como respuesta al crecimiento de las ciudades latinoamericanas y la búsqueda de seguridad y exclusividad. Se exploran las implicaciones de este modelo, como la fragmentación urbana y la segregación social. Objetivo: Evaluar las urbanizaciones cerradas en Cuenca para proponer estrategias de diseño urbano-arquitectónicas que contribuyan a un desarrollo más sostenible y equitativo, sustituyendo el modelo tradicional.  Metodología: El estudio utiliza un enfoque cualitativo e interdisciplinario, basado en una revisión bibliográfica exhaustiva y análisis descriptivo y correlacional. Se emplea una matriz sintético-deductiva que integra lineamientos urbanísticos de la ONU para evaluar la habitabilidad y sostenibilidad de estas urbanizaciones. Resultados: Se identificaron diferencias marcadas en la percepción social entre los residentes dentro de la urbanización ("Los de adentro") y aquellos fuera de ella ("Los de afuera"). Los residentes internos valoran la seguridad y exclusividad, mientras que los externos sienten una desconexión y aumento de la delincuencia debido a la segregación espacial Conclusión: Las urbanizaciones cerradas en Cuenca reflejan desafíos similares observados en otras regiones, como la segregación social y espacial. Se necesitan políticas sostenibles que integren mejor estas comunidades con el tejido urbano de la ciudad, garantizando una calidad de vida más alta y un desarrollo urbano cohesivo y sostenible. Área de estudio general: Arquitectura Área de estudio específica:  Urbanismo.
Riverine Community Vulnerability to Flooding: An Insight from the Bramhaputra-Jamuna River at Harirampur Upazila, Manikganj
Authors: Malak Md Abdul , Rahman Md Mafizur , Khan Seam Ur Rahman , Quader Mohammad Abdul
Published: May 2024

Bangladesh is one of the nations that has a distinctive environment for floods. Most of the land is low-lying, and 80% is a floodplain, making it highly susceptible to frequent flooding. This research aims to investigate the susceptibility of riverine communities to flooding and display the spatial distribution of vulnerability for the study region (Harirampur Upazila). A vulnerability assessment index is developed using multiple variables related to social, physical, and economic vulnerability. A quantitative survey is conducted to gather data on physical, social, and economic factors contributing to household vulnerability to floods. The results reveal that out of the five unions in Harirampur Upazila, Gopinathpur, and Lesraganj unions, they have been found to have a high vulnerability to flooding (vulnerability scores of 3.19 and 3.10, respectively). Kanchanpur Union is severely vulnerable to flooding (score 3.57). On the other hand, Gala Union is designated as a lowly vulnerable (score of 2.23) area, and Ramkrishnapur Union is classified as a moderately vulnerable (score of 2.83) area. Finally, this study would help to assign government and non-government initiatives following the vulnerability category during critical conditions of any disaster period.
Jagannath University Journal of Life and Earth Sciences, 9(2): 195-214, 2023 (December)
Microbial Pollution with Antibiotic Resistant Bacteria in the Buriganga River of Dhaka, Bangladesh
Authors: Kabir Md Anamul , Sarker Md Riaz , Rana Md Sohel , Biswas Kapil , Akhtar Sadia , Azad Abul Kalam , Mia Md Zakaria
Published: May 2024

Dhaka, the capital of Bangladesh, is located on the bank of the Buriganga River. Pollution of Buriganga river water with different types of waste containing antibiotic-resistant (AR) bacteria poses a threat to human health. Therefore, this study aims to analyze the physicochemical parameters, total aerobic bacterial count (TBC), total coliform count (TC), and antibiotic-resistant bacteria from waste disposal points located in the river seasonally. We collected 59 water samples from sewage waste (SW), 31 from industrial waste (IW), and 9 from hospital waste (HW) disposal sites during the wet (November to April) and dry (May to September) seasons in the Buriganga river. We found that water temperature, pH, BOD, and COD decreased, but water total dissolved solids (TDS) increased significantly in the dry season compared to the wet season. Bacteriological analysis showed that total TBC and TC were significantly increased in the dry season compared to the wet. Further analysis showed that TBC and TC from the water of SW and HW disposal sites increased in the dry season compared to the wet. However, TBC and TC from the water at IW disposal sites were not changed. These results indicate that SW and HW are the main contributors to the bacterial coliform contamination in the Buriganga River. Escherichia coli, Pseudomonas spp., Staphylococcus aureus, Streptococcus spp., and Salmonella spp. isolates showed a high prevalence of resistance against commonly used antibiotics. It can be concluded that SW and HW might spread AR bacteria in the water of the Buriganga River, which causes a significant threat to humans and the environment.
Jagannath University Journal of Life and Earth Sciences, 9(2): 215-226, 2023 (December)
AI-powered smart assistants: Your key to self-learning success
Authors: Praherdhiono Henry , Jamaludin Jamaludin , Kurniawan Citra , Afriani Afriani , Dhini Bachriah Fatwa , Sumarno Alim , Kristanto Andi , Pinandito Aryo
Published: May 2024

This research aims to develop a prototype of a smart assistant system for independent learning activities based on Artificial Intelligence. Web-based instructional design (WBID) approach is used in research to develop intelligent assistant systems. Artificial Intelligence-Learning Analytics helps students make important decisions and creates an effective and efficient learning environment while still building learning independence. The method used is a research and development (R&D) approach. The findings of this research are an intelligent assistant system in independent learning activities assisted by artificial intelligence in the form of the AILA ChatBot application. In the end, this research concludes that the ChatBOT application developed in this research is used to provide recommendations for using AI applications to students, which are then implemented and integrated into SPOC/MOOC.
Risk Factors for Aggravation of Myopic Retinoschisis after Intravitreal Bevacizumab Injection in Myopic Choroidal Neovascularization
Authors: Song Ji Yoon , Kim Jong Min
Published: May 2024

Purpose: We evaluated the factors associated with the development and progression of retinoschisis in patients with myopic choroidal neovascularization (CNV) treated with intravitreal bevacizumab injections.Methods: We conducted a retrospective analysis of 54 eyes with myopic CNV treated with intravitreal bevacizumab injections. We compared optical coherence tomography findings at baseline and final follow-up visits to assess the occurrence and progression of retinoschisis. Furthermore, we analyzed potential risk factors associated with the occurrence and progression of retinoschisis.Results: During a mean follow-up of 42.82 ± 27.12 months, retinoschisis worsened in 11 eyes (20.3%), including 7 eyes with new-onset disease and 4 with progression. The aggravated group demonstrated a significantly longer baseline axial length compared to the non-aggravated group (31.21 ± 2.52 μm vs. 29.21 ± 1.64 μm, p = 0.011). Univariate logistic regression analysis identified axial length (p = 0.041) and pre-existing outer retinoschisis (p = 0.018) as potential predictors of retinoschisis aggravation. In a multivariate analysis, axial length remained significantly associated with retinoschisis aggravation (p = 0.038, odds ratio = 2.63).Conclusions: Our study emphasized that a longer axial length is a risk factor for the development or progression of retinoschisis in myopic CNV patients treated with intravitreal bevacizumab injections. Therefore, closer monitoring during treatment may be warranted for myopic CNV patients with long axial length at baseline.
Circulatory Failure in the Central Retinal Artery during Medial Orbital Wall Blow-out Fracture Repair
Authors: Nah Jun Sung , Mun Junho , Choi Youn Joo
Published: May 2024

Purpose: We report a case of visual impairment due to circulatory failure in the central retinal artery during blow-out fracture repair.Case summary: A 16-year-old male with no underlying disease was diagnosed with a trapdoor type medial orbital wall blow-out fracture after a motorcycle accident and underwent blow-out fracture repair. During the surgery, his left eye was nearly completely dilated. Postoperatively, the visual acuity in the left eye was hand motion and there was ptosis of the left upper eyelid. Concerned with the possibility of orbital implant compression, computed tomography was performed immediately and a second operation was performed. However, there was no direct compression originating from the intraocular implant or any signs of active bleeding. The following day, optical coherence tomography and fluorescein angiography revealed a cherry-red spot on the central fovea with edema of the inner retinal layer and delayed arterial circulation. Under a diagnosis of incomplete central retinal artery occlusion, the patient was treated with intraocular pressure-lowering eye drops and intravenous mannitol. Despite prompt intervention, the visual acuity of the left eye did not improve beyond 0.04 at the 2-year follow-up.Conclusions: When there is visual impairment and pupillary dilation after blow-out fracture repair, we should consider not only compressive factors but also the possibility of central retinal artery occlusion or circulatory failure. In such cases, retinal examinations should be done to assess the retinal blood flow and enable early detection of any complications allowing prompt appropriate intervention.
Measurement of Physical and Mental Workload in Onlline Ojek Drivers: A Case Study in Serang City
Authors: Kusmasari Wyke , Mahirah Alifia , Nalhadi Ahmad
Published: May 2024

The development of online motorcycle taxi transportation has received a good response in the community. With this application, it makes it easier for people to order motorcycle taxis more practically. Many online motorcycle taxi drivers have complaints while working, one of which is the obligation to meet life's necessities which causes the physical and mental workload to increase. This study aims to measure the physical and mental workload of online motorcycle taxi drivers in Serang City. Data collection was carried out by measuring heart rate with a Polar H10 and filling out the NASA-TLX questionnaire which was distributed to online motorcycle taxi drivers who were willing to be respondents. Data processing starts from measuring heart rate, with an average %CVL value obtained of 40.08%. This value is included in the physical workload category that requires improvement. Mental workload data, calculated through the NASA-TLX method, averaged 74.20, which is classified as high. To alleviate these workloads, it's suggested to incorporate 90-minute break periods, redesign automatic motorcycles with extra footrests, use energy sprays, implement road congestion detection tools, enhance the quality of ride-hailing apps, and minimize exposure to heat stress.
Quantification of marine metazooplankton: Do we need to include juveniles?
Authors: Paffenhöfer GA , Köster M
Published: May 2024

In 1966, Working Party 2 of the Scientific Committee on Ocean Research (SCOR) chose the mesh size of 200 µm to collect zooplankton of a width of >200 µm. In the proceeding decades, research has described various zooplankton taxa with widths narrower than 200 µm. For example, we have become more aware of the existence of juvenile stages and small zooplankton species. Yet, utilizing nets with 200 µm mesh has continued to some extent, although it is recognized that juvenile stages and smaller species are not quantitatively collected. We suggest that zooplankton sampling be reconsidered by using meshes or methods which quantitatively collect small species and juvenile stages (nauplii and copepodids). These new methods should take into account the narrowest dimensions of the taxon to be studied, thus allowing quantitative sampling of the forms under investigation. To maintain previous time-series, we suggest to continue sampling with cylinder-cone nets of 200 µm mesh for mesozooplankton and add sampling with 30 l Go/Flo bottles at various depths sieved through 20 µm mesh to retain all nauplii and small copepodid stages.
Assessing the Role of Green Economy on Sustainable Development in Developing Countries
Authors: Jiemuratov T. , Muratbaev B. , Kaldaubekova N.
Published: May 2024

Over the past few years, the idea of a green economy has become a key tool for achieving sustainable development in both developing and developed countries. The article examines the role of the green economy in achieving sustainable development in developing countries. By studying the relationship between green economy and various dependent variables such as GDP per capita, overall unemployment rate and poverty rate.
Annulment of Discriminatory Custom and its Impact on Matrilineal and Patrilineal Societies/People
Authors: O’Sullivan Maureen , Ugbe Rose Ohiama , Izzi Mabel , Emudainohwo Emuobo , Jack-Osimiri Uche
Published: May 2024

The case of Ukeje v. Ukeje raises important questions about ways in which universal human rights are to be applied and their impact on culturally diverse societies such as patrilineal and matrilineal communities. Although the Constitution is supreme, the various ethnic groups actually gave themselves the Constitution, subject to amendment if it disparaged their cultural diversity. This article appraises similar developments in Ghana, Tanzania, Kenya, Zambia, Uganda, South Africa and the South-Pacific, examining the challenges and limitations when daughters get married in patrilineal societies and when sons get married in matrilineal communities. Reform is advocated through the enactment of modernised Succession Acts such as those found in Kenya and Zambia where courts are given powers to determine inheritance cases according to their peculiarities and to impose statutory trusts for sale where necessary.
Introduzione al problem solving in una classe prima primaria
Authors: Seneci Caterina
Published: May 2024

Questo articolo intende descrivere le attività maggiormente significative del percorso svolto da una classe prima primaria in merito all’attività di problem solving, intesa come una delle attività principali e fondamentali del curricolo di matematica. Uno degli obiettivi del percorso è quello di introdurre l’abitudine ad affrontare problemi matematici (e non) senza che si instaurino stereotipie e abitudini rigide. Altri obiettivi del percorso riguardano il coinvolgimento di tutti gli alunni e l’importanza di accogliere tutte le strategie risolutive proposte dagli alunni per la risoluzione dei problemi affrontati. Grande rilievo è dato anche al ruolo dell’argomentazione sia orale che scritta, considerata ovviamente tenendo conto dell’età degli scolari (6 anni).
Translation from German to English of: ‘Zur kenntniss der resorption einfacher, im besonderen stereoisomer zucker im dünndarm’ by Junzo Nagano.
Authors: Richards Thomas , McAleer Kevin , Kilias Estelle
Published: May 2024

Here we present a translation from German to English of a scientific paper titled ‘On the knowledge of the absorption of simple, in particular stereoisomeric sugars in the small intestine’ published in the journal Pflugers Arch. 90:389–404 in 1902 [1]. We provide the translation because this work represents an important contribution to the historical scientific record focusing on cell membrane function. We have included a brief foreword highlighting some of the scientific and historical context of the work.
Pengembangan Pencatatan Laporan Keuangan UMKM Berbasis Teknologi Informasi
Authors: Andari Atik Tri , Setianingsih Novie Astuti , Asmoro Wiwiek Kusumaning , Cinderatama Toga Aldila , Putranti Eti
Published: May 2024

UMKM merupakan salah satu penggerak ekonomi dalam meningkatkan pendapatan daerah. Pisang Gimbal merupakan salah satu UMKM di bidang kuliner yang berbahan dasar pisang. Pada saat ini mitra masih melakukan pencatatan pembukuan secara manual dan belum membuat laporan keuangan. Mitra hanya melakukan pencatatan pemasukan dan pengeluaran tanpa melakukan perhitungan laba atau rugi. Berdasarkan hal tersebut, maka tujuan program ini adalah memberikan pendampingan untuk pencatatan laporan keuangan yang berbasis teknologi informasi, sehingga akan menghasilkan laporan keuangan yang mudah dan tepat. Pendampingan ini dilaksanakan di UMKM Pisang Gimbal di Jl. Setono No. 82b Kecamatan Ngadirejo Kota Kediri. Terdapat enam tahapan dalam melaksanakan kegiatan meliputi koordinasi tim, koordinasi tim dengan mitra, pengadaan aplikasi pencatatan laporan keuangan berbasis teknologi informasi, pelatihan aplikasi berbasis teknologi informasi, evaluasi kegiatan, dan pelaporan. Hasil dari program ini adalah peningkatan kemampuan mitra dalam mencatat laporan keuangan menggunakan aplikasi sistem pengelolaan keuangan Pisang Gimbal.
Bimbingan Teknis Inventaris Arsip Dokumen dan Bantuan Pengadaan Ruang Penyimpanan di Masjid Darul Mujahidin
Authors: Diana Irmawati Pradani  , Jayaputra Harsalim A. , Pratama Gindang Rain , Novianto Dandung
Published: May 2024

Abstrak
Kegiatan pengabdian kepada masyarakat kali ini berlokasi di Takmir Masjid Darul Mujahidin yang merupakan salah satu organisasi masyarakat yang bergerak dalam bidang agama yang berada di Kecamatan Kedungkandang yang berlokasi di Jl. Rawa Pening No. 12 Kelurahan Madyopuro Kota Malang. Saat ini banyak sarana dan prasarana penunjang yang dimiliki oleh kepengurusan Takmir Masjid Darul Mujahidin. Salah satu yang menjadi permasalahan ialah mengenai inventarisir barang yang menjadi  tanggung jawab pengurus organisasi belum dilakukan dengan baik. Selain itu penyimpanan dokumen penting juga belum tertata rapi. Demi menyempurnakan pengurusan dan pengawasan yang efektif terhadap sarana dan prasaran yang dimiliki organisasi terpilihlah pengadaan almari sebagai prioritas dalam pelaksanaan inventarisir pada Takmir Masjid Darul Mujahidin pada kegiatan pengabdian masyarakat ini. Setelah dilakukan penyerahan almari pada pihak Takmir Masjid Darul Mujahidin, selanjutnya dilakukan penyampian informasi terkait inventarisir dokumen / barang berupa Focus Group Discussion (FGD) kepada para pengurus mengenai langkah-langkah yang perlu dilakukan dalam inventarisir. Diharapkan dengan adanya bimbingan teknis tersebut, organisasi pada Takmir Masjid Darul Mujahidin dapat berjalan lebih optimal terkait tentang pentingnya inventarisir dokumen / barang, sehingga nantinya akan menimbulkan rasa memiliki menjaga keberadaan barang invetarisir tersebut.
Knowledge and Awareness of Smoking on Oral Health among Non-Medical Students in Salem District
Authors: D. Kiruthika , M. Ambika
Published: May 2024

Introduction Smoking is a global health concern not only for respiratory health but also for an oral health which includes oral cancer and gum disease. Smoking recently has become a common habit developed by early adolescence. AIM: To assess the knowledge and awareness of smoking on oral health among non-medical students in Salem district. Material and Methods A set of questions approved by the two experts were used to assess the awareness and effects of smoking on oral health. The sample will include all the non-medical students under the age of 18-24 years. The objective of the study is to communicate them, and the volunteers were asked to complete the questionnaire. The questionnaire is divided into three sections; demographic details of education level and location, awareness about the effects of smoking on oral health and willingness to participate in smoking cessation program to quit smoking. Results Out of 1000 students 997 completed the questionnaire. The participants were between the age group of 18-24 years. 43.7% participants accepted that smoking can cause tooth staining, around 46% know about smoking cause gum diseases and only 36% responded about its cause for delayed wound healing and 63% know that smoking can cause cancer. Among the participants 60.2% family member smoke and only 27.1% were willing to recommend them for smoking cessation program. Conclusion Public awareness initiates when the young adults are educated priorly. Hence awareness and knowledge of effects of smoking on oral health among young adults will help in eradicating the smoking habit from the society. Key Words Non-medical students, Oral health, Smoking, Tobacco
Prosthetic status and Treatment need in Indian population:A Systematic Review
Authors: Jogi Shreyasi , Deshpande Saee , Pande Neelam , Nahrare Reena
Published: May 2024

Introduction
To examine the prevalence of partial or complete edentulousness in different geographic areas of the Indian population.

Materials and Methods
An electronic search in PubMed/Medline, Cochrane Library, ScienceDirect, Wiley Online Library, and Google Scholar was conducted to find relevant papers that had been written in English exclusively and published before May 2022. Based on the PICO, the primary research question for this study was ‘What are the prosthetic status and treatment needs of the adult population in India?’ By evaluating the title, abstract, and full text of the articles, if they met the inclusion criteria, the relevance of the articles was verified. The quality of the included studies was assessed using the Joanna Briggs Institute (JBI) tool for analytical cross-sectional studies.

Result
The database search yielded 278 items, of which 123 were discarded due to being irrelevant, duplicates, or lacking data. The remaining 155 full-text articles were assessed for eligibility 20 articles were yielded by manual search and 9 articles were added through a search of a reference list of relevant articles. A total of 151 full-text papers were evaluated for eligibility, with 5 articles being excluded. The current systematic review includes a total of 35 studies.

Conclusion
The current systematic review states the prevalence of complete edentulousness is comparatively less than partial edentulism, ranging between 0.8% to 14%, except for the tribal population where it is around 42-43%. On the other hand, figures depicting partial edentulism are between 15 to 98% distributed in the different geographical regions. The prosthetic status reported in the studies involved ranges between 3% to 100% with a mean of approximately 35%. Prosthetic treatment need reported overall was between 14% to 100%, in which requirement was found to be more in the maxilla in maximum of the studies included while only a few studies predicted more treatment need in the mandible. The requirement and correlation with gender cannot be established as the figures vary in all the studies included. This research establishes a baseline reference and highlights the lack of attention given to oral health.

Key Words: Geographic areas, Population, Prosthetic treatment
Targeted complement inhibition using bispecific antibodies that bind local antigens and endogenous complement regulators
Authors: Wang Haiyu , van de Bovenkamp Fleur S. , Dijkstra Douwe J. , Abendstein Leoni , Borggreven Nicole V. , Pool Jos , Zuijderduijn Rob , Gstöttner Christoph , Gelderman Kyra A. , Damelang Timon , Vidarsson Gestur , Blom Anna M. , Domínguez-Vega Elena , Parren Paul W. H. I. , Sharp Thomas H. , Trouw Leendert A.
Published: May 2024

Complement activation protects against infection but also contributes to pathological mechanisms in a range of clinical conditions such as autoimmune diseases and transplant rejection. Complement-inhibitory drugs, either approved or in development, usually act systemically, thereby increasing the risk for infections. We therefore envisioned a novel class of bispecific antibodies (bsAbs) which are capable of site-directed complement inhibition by bringing endogenous complement regulators in the vicinity of defined cell surface antigens. Here, we analyzed a comprehensive set of obligate bsAbs designed to crosslink a specific target with either complement regulator factor H (FH) or C4b-binding protein (C4BP). The bsAbs were assessed for their capacity to inhibit complement activation and cell lysis in an antigen-targeted manner. We observed that the bsAbs inhibited classical, lectin, and alternative pathway complement activation in which sufficient endogenous serum FH and C4BP could be recruited to achieve local inhibition. Importantly, the bsAbs effectively protected antigen-positive liposomes, erythrocytes, and human leukocytes from complement-mediated lysis. In conclusion, localized complement inhibition by bsAbs capable of recruiting endogenous human complement regulators (such as FH or C4BP) to cell surfaces potentially provides a novel therapeutic approach for the targeted treatment of complement-mediated diseases.
Hydrogeochemical characteristics of shallow groundwater and salinization evaluation in the coastal aquifers of Cangzhou, China
Authors: Li Hui , Liu Yang , Wang Chaoyue , Yu Kaining , Zhou Yahong , Fu Xiaogang , Bai Xiaoli , Li Xin
Published: May 2024

To investigate the hydrogeochemical characteristics of shallow groundwater and evaluate groundwater salinization state in Cangzhou, China, two sampling campaigns have been conducted. In summer, 33 groundwater samples, 3 seawater samples and 5 river water samples were collected. In winter, 22 groundwater samples were collected. The hydrochemical type was determined by the Piper diagram. Evolution mechanisms of groundwater were analyzed by the Gibbs diagram. The trend of de-salinization or salinization of groundwater was determined by the hydrochemical facies evolution diagram. The groundwater salinization grade was evaluated by both the seawater intrusion groundwater quality index (GQISWI) and the attribute recognition model based on entropy weight (ARMEW). The Piper diagram shows that Na+ is the dominant cation and Cl- is the dominant anion in shallow groundwater, and the groundwater in this area is mainly of Cl-Na type followed by Cl-Ca·Mg type. The evaporation-crystallization process has significant influence on the evolution of saline groundwater. In summer, most brackish groundwater exhibit compositions of the freshening stage with direct cation exchange, and most saline groundwater is mainly at the seawater intrusion stage with reverse cation exchange. In winter, compared to the summer season, more groundwater samples in the middle of study area exhibit intrusion trend, and without obvious Na-HCO3 facies. In summer, values of GQISWI range from 20.47 to 75.38 with an average of 59.31. The GQISWI gradually increases from east to west, denoting the degree of groundwater salinization is alleviated from coast to inland. In winter, values of GQISWI range from 54.47 to 79.09 with an average of 66.00, slightly higher than that in summer. The proportion of no salinization (Grade I), minor salinization (Grade II) and serious salinization (Grade III) of groundwater samples in Cangzhou identified by ARMEW is 3.0%, 21.2% and 75.8% in summer, respectively. In winter, the proportion is 9.1% for Grade II and 90.9% for Grade III. The GQISWI index shows the largest area of Grade II, and ARMEW presents the largest area of Grade III in both seasons. Compared with GQISWI index, ARMEW model gives more conservative evaluation results of groundwater salinization. The results provide useful information on the groundwater salinization status for the local area, and help for the management of groundwater resources in Cangzhou.
Information bottleneck-based Hebbian learning rule naturally ties working memory and synaptic updates
Authors: Daruwalla Kyle , Lipasti Mikko
Published: May 2024

Deep neural feedforward networks are effective models for a wide array of problems, but training and deploying such networks presents a significant energy cost. Spiking neural networks (SNNs), which are modeled after biologically realistic neurons, offer a potential solution when deployed correctly on neuromorphic computing hardware. Still, many applications train SNNs offline, and running network training directly on neuromorphic hardware is an ongoing research problem. The primary hurdle is that back-propagation, which makes training such artificial deep networks possible, is biologically implausible. Neuroscientists are uncertain about how the brain would propagate a precise error signal backward through a network of neurons. Recent progress addresses part of this question, e.g., the weight transport problem, but a complete solution remains intangible. In contrast, novel learning rules based on the information bottleneck (IB) train each layer of a network independently, circumventing the need to propagate errors across layers. Instead, propagation is implicit due the layers' feedforward connectivity. These rules take the form of a three-factor Hebbian update a global error signal modulates local synaptic updates within each layer. Unfortunately, the global signal for a given layer requires processing multiple samples concurrently, and the brain only sees a single sample at a time. We propose a new three-factor update rule where the global signal correctly captures information across samples via an auxiliary memory network. The auxiliary network can be trained a priori independently of the dataset being used with the primary network. We demonstrate comparable performance to baselines on image classification tasks. Interestingly, unlike back-propagation-like schemes where there is no link between learning and memory, our rule presents a direct connection between working memory and synaptic updates. To the best of our knowledge, this is the first rule to make this link explicit. We explore these implications in initial experiments examining the effect of memory capacity on learning performance. Moving forward, this work suggests an alternate view of learning where each layer balances memory-informed compression against task performance. This view naturally encompasses several key aspects of neural computation, including memory, efficiency, and locality.
Inflammation and endothelial function relevant genetic polymorphisms, carotid atherosclerosis, and vascular events in high-risk stroke population
Authors: Chen Hong , Qing Ting , Luo Hua , Yu Ming , Wang Yanfen , Wei Wei , Xie Yong , Yi Xingyang
Published: May 2024

Aim

To identify the associations of 19 single nucleotide polymorphisms (SNPs) in genes involved in inflammation and endothelial function and carotid atherosclerosis with subsequent ischemic stroke and other vascular events in the high-risk stroke population.

Methods

This was a multicenter community-based sectional survey and prospective cohort study in Sichuan, southwestern China. Eight communities were randomly selected, and the residents in each community were surveyed using a structured face-to-face questionnaire. Carotid ultrasonography and DNA information were obtained from 2,377 out of 2,893 individuals belonging to a high-risk stroke population. Genotypes of the 19 SNPs in genes involved in inflammation and endothelial function were measured. All the 2,377 subjects were followed up for 4.7 years after the face-to-face survey. The primary outcome was ischemic stroke, and the secondary outcome was a composite of vascular events.

Results

Among the 2,377 subjects, 2,205 (92.8%) completed a 4.7-year follow-up, 947 (42.9%) had carotid atherosclerosis [372 (16.9%) carotid vulnerable plaque, 405 (18.4%) mean IMT > 0.9 mm, 285 (12.0%) carotid stenosis ≥15%]. Outcomes occurred in 158 (7.2%) subjects [92 (4.2%) ischemic stroke, 17 (0.8%) hemorrhagic stroke, 48 (2.2%) myocardial infarction, and 26 (1.2%) death] during follow-up. There was a significant gene–gene interaction among ITGA2 rs1991013, IL1A rs1609682, and HABP2 rs7923349 in the 19 SNPs. The multivariate logistic regression model revealed that carotid atherosclerosis and the high-risk interactive genotypes among the three SNPs were independent with a higher risk for ischemic stroke (OR = 2.67, 95% CI: 1.52–6.78, p = 0.004; and OR = 3.11, 95% CI: 2.12–9.27, p < 0.001, respectively) and composite vascular events (OR = 3.04, 95% CI: 1.46–6.35, p < 0.001; and OR = 3.23, 95% CI: 1.97–8.52, p < 0.001, respectively).

Conclusion

The prevalence of carotid atherosclerosis was shown to be very high in the high-risk stroke population. Specific SNPs, interactions among them, and carotid atherosclerosis were independently associated with a higher risk of ischemic stroke and other vascular events.
Dollar store policy opportunities in Baltimore City: community member and policy maker perspectives
Authors: Sundermeir Samantha M. , Santos Sydney R. , Lewis Emma C. , John Sara , Gardner Karen , Friedman Emily , Poirier Lisa , Hua Shuxian , Peoples-Brown Sevetra , Benjamin-Neelon Sara E. , Gittelsohn Joel
Published: May 2024

Introduction

There are currently over 50 dollar stores in Baltimore City, Maryland. Community perceptions of over-saturation and resulting neighborhood impacts have garnered recent attention. A Maryland State Senate Bill required further study of dollar stores in Baltimore City to inform future policy. Therefore, the over-arching goal of this study was to generate community-informed policy recommendations for the Baltimore City Council.

Methods

Three methods of data collection were used: (1) in-depth interviews with community members, retail staff/owners, dollar store staff, and policy makers; (2) an online survey of Baltimore City residents; and (3) workshop with community members and one with policy makers. Triangulation across data sources, discussion amongst the research team, and member checking were used to generate the top four policy options: a conditional use ordinance, a community benefits agreements, a dispersal ordinance, and a staple foods ordinance.

Results

There was strong support for policies that encourage dollar stores to better align with community priorities (e.g., improving store cleanliness and appearance, increasing availability of healthy foods), as opposed to closing or banning dollar stores entirely. There was also strong support for policies that would empower communities to participate in determining the role of dollar stores in their neighborhoods, for example through a conditional use ordinance or community benefits agreement. Key concerns included policy enforcement, given the additional funding required, and current limited capacity at the city government level. Strategies to address such challenges were generated including implementing business licenses at the city level, linking new ordinances to dollar store leases and permits, and encouraging dollar store participation in federal and local programs to more feasibly stock healthier food items (e.g., fresh produce). Dissatisfaction was expressed regarding a lack of policy options to address the existing dollar stores, not just new dollar stores entering the City.

Discussion

This study is the first of its kind to assess community support for dollar store policies at the local level, and serves to inform policies that improve dollar stores. A report of these findings was provided to Baltimore City Council to inform new, community-supported dollar store policies.
Neratinib, a pan ERBB/HER inhibitor, restores sensitivity of PTEN-null, BRAFV600E melanoma to BRAF/MEK inhibition
Authors: DuBose Evan , Bevill Samantha M. , Mitchell Dana K. , Sciaky Noah , Golitz Brian T. , Dixon Shelley A. H. , Rhodes Steven D. , Bear James E. , Johnson Gary L. , Angus Steven P.
Published: May 2024

Introduction

Approximately 50% of melanomas harbor an activating BRAFV600E mutation. Standard of care involves a combination of inhibitors targeting mutant BRAF and MEK1/2, the substrate for BRAF in the MAPK pathway. PTEN loss-of-function mutations occur in ~40% of BRAFV600E melanomas, resulting in increased PI3K/AKT activity that enhances resistance to BRAF/MEK combination inhibitor therapy.

Methods

To compare the response of PTEN null to PTEN wild-type cells in an isogenic background, CRISPR/Cas9 was used to knock out PTEN in a melanoma cell line that harbors a BRAFV600E mutation. RNA sequencing, functional kinome analysis, and drug synergy screening were employed in the context of BRAF/MEK inhibition.

Results

RNA sequencing and functional kinome analysis revealed that the loss of PTEN led to an induction of FOXD3 and an increase in expression of the FOXD3 target gene, ERBB3/HER3. Inhibition of BRAF and MEK1/2 in PTEN null, BRAFV600E cells dramatically induced the expression of ERBB3/HER3 relative to wild-type cells. A synergy screen of epigenetic modifiers and kinase inhibitors in combination with BRAFi/MEKi revealed that the pan ERBB/HER inhibitor, neratinib, could reverse the resistance observed in PTEN null, BRAFV600E cells.

Conclusions

The findings indicate that PTEN null BRAFV600E melanoma exhibits increased reliance on ERBB/HER signaling when treated with clinically approved BRAFi/MEKi combinations. Future studies are warranted to test neratinib reversal of BRAFi/MEKi resistance in patient melanomas expressing ERBB3/HER3 in combination with its dimerization partner ERBB2/HER2.