bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of the Time-Lapse Changes with the DAS Borehole Data at the Brady Geothermal Field Using Deconvolution Interferometry
Authors: Chang Hilary , Nakata Nori
Published: November 2021

The distributed acoustic sensing (DAS) has great potential for monitoring natural-resource reservoirs and borehole conditions. However, the large volume of data and complicated wavefield add challenges to processing and interpretation. In this study, we demonstrate that seismic interferometry based on deconvolution is a convenient tool for analyzing this complicated wavefield. We extract coherent wave from the observation of a borehole DAS system at the Brady geothermal field in Nevada. Then, we analyze the coherent reverberating waves, which are used for monitoring temporal changes of the system. These reverberations are tirelessly observed in the vertical borehole DAS data due to cable or casing ringing. The deconvolution method allows us to examine the wavefield at different boundary conditions. We interpret the deconvolved wavefields using a simple 1D string model. The velocity of this wave varies with depth, observation time, temperature, and pressure. We find the velocity is sensitive to disturbances in the borehole related to increasing operation intensity. The velocity decreases with rising temperature, which potentially suggests that the DAS cable or the casing are subjected to high temperature. This reverberation can be decomposed into distinct vibration modes in the spectrum. We find that the wave is dispersive, and the the fundamental mode propagate with a large velocity. The method can be useful for monitoring borehole conditions or reservoir property changes. For the later, we need better coupling than through only friction in the vertical borehole to obtain coherent energy from the formation.
Amphiphilic Carboxymethyl Dextran Nanomicelles for Antibacterial Coating on Titanium
Authors: Wei Hongbo , Zhou Minghao , Ye Weiliang , Zhang Luxuan , Yu Jingwei
Published: November 2021

Peri-implantitis occurs at a significant rate, which is the leading cause of implant failure. The main reason for this unwanted complication is bacterial invasion and biofilm formation. To reduce the incidence of peri-implantitis, we constructed a carboxymethyl dextran (CMD) based nanomicelles antibacterial coating on microarc-oxidized titanium (MAO-Ti) surface. After cross-linking, the drug-loaded nanomicelles were spherical with a particle size of 130nm and uniformly dispersed. Zeta potential was negative, and the absolute value was greater than 10 mV, effectively avoiding micelles aggregation. It was observed by dynamic light scattering (DLS) that the stability of nanomicelles was significantly improved after cross-linking. The hemolysis rate of micelles was less than 5%, and the overall survival rate of human umbilical vein endothelial cells was more than 90%. After being coated on MAO-Ti surface, the cumulative drug release rate of drug-loaded nanomicelles reached 86.6% after 360 hours. Fluorescence staining of immobilized bacteria showed more dead bacteria on the coating surface, and the number of live bacteria was significantly reduced. It was concluded that dextran-based nanomicelles, which showed long-term drug release properties and excellent biocompatibility, are potential drug carriers for fabricating antibacterial coating on titanium surfaces.
Dijital Bağımlılık ile Yaratıcı Düşünme Eğilimi Arasındaki İlişkinin İncelenmesi: Üniversite Öğrencileri Üzerine Bir Araştırma
Authors: TAŞLIYAN Mustafa , KARAKUŞ Fatma Nur , ÇAKIROĞLU Zeliha
Published: November 2021

Amaç: Bu araştırmanın amacı, üniversite öğrencilerinin dijital bağımlılık düzeyleri ve yaratıcı düşünme eğilimlerini ve aralarındaki ilişkileri çeşitli değişkenler itibariyle incelenmektir.

Tasarım/Yöntem: Araştırmada tesadüfi olmayan yöntemlerden kolayda örneklem yöntemiyle belirlenen 400 katılımcı ile yüz yüze anket yapılmış ve 377 anket değerlendirmeye alınmıştır. Elde edilen veriler SPSS 21 paket programı ile analiz edilmiştir.

Bulgular: Katılımcıların yaratıcı düşünme eğilimi düzeylerine göre dijital bağımlılık ölçeği boyutlarından “nüksetme” ve “bırakamama” arasında anlamlı bir farklılık olduğu sonucuna ulaşılmıştır. Katılımcıların öğrenim gördüğü fakülteler itibariyle yaratıcı düşünme eğilimi ve dijital bağımlılık puanları arasında anlamlı bir farklılığa ulaşılamamıştır. Cinsiyetler itibariyle dijital bağımlılık düzeyleri arasında anlamlı bir farklılığa ulaşılamamış ancak yaratıcı düşünme eğilimleri açısından erkekler lehine anlamlı bir farklılık bulunmuştur. Katılımcıların akademik başarıları ile dijital bağımlılıkları arasında ve dijital oyun oynama durumları ile yaratıcı düşünme eğilimleri arasında anlamlı bir fark bulunamamıştır. Korelasyon analizi sonuçlarına göre ise dijital bağımlılık ölçeği “nüksetme” ve “bırakamama” boyutları ile yaratıcı düşünme eğilimleri arasında kısmen anlamlı ilişkilere ulaşılmıştır.

Sınırlılıklar: Örneklemin sadece Kahramanmaraş Sütçü İmam Üniversitesi öğrencilerinden oluşması ve kolayda örnekleme yöntemi kullanılması bakımından sonuçların genellenememesi araştırmanın kısıtları arasındadır.

Özgünlük/Değer: Literatür incelendiğinde dijital bağımlılığın yaratıcı düşünme eğilimi ile ilişkisinin incelendiği bir çalışma ile karşılaşılmamıştır. Bu nedenle hem konusu ve yöntem hem de sonuçları bakımından araştırma özgün bir nitelik taşımaktadır.
BIODIVERSITY DISCLOSURE OF INDONESIAN COMPANIES AND THE ROLE OF THE BOARD OF COMMISSIONERS
Authors:   Universitas Indonesia, Hambali Ahmad , Adhariani Desi ,   Universitas Indonesia
Published: November 2021

The environmental damage that occurs on a large scale has an impact on reducing biodiversity. Biodiversity has an important role that is useful for human life and plays a central role in economic development. This condition makes various parties aware of their role in preventing further damage. Companies, whether directly or indirectly, owe a great deal to the environment. This study seeks to examine the role of the Board of Commissioners as proxied by the size of the Board of Commissioners, the proportion of Independent Boards, and the proportion of women on the Board of Commissioners as a corporate governance mechanism for their biodiversity disclosure. The companies used as samples are listed in the SRI-KEHATI index from 2018 to 2020. To measure the company's biodiversity variable, we use a biodiversity index which contains 53 measurement items in 5 main themes. As a result, we find that the size of the Board of Commissioners has a positive effect on the company's biodiversity disclosure. Meanwhile, the proportion of Independent Commissioners and the proportion of women on the Board of Commissioners are proven to have no effect on the company's biodiversity disclosure.
Capsular Closure Following Hip Arthroscopy for Femoroacetabular Impingement
Authors: Economopoulos Kostas J. , Chhabra Anikar , Hassebrock Jeffrey D. , Kweon Christopher
Published: November 2021

Background:

Recent literature has suggested that capsular closure following hip arthroscopy restores native hip-joint kinematics and may lead to better patient-reported outcomes, especially in high-level athletes
1–4
.

Description:

Capsular closure of the hip occurs following standard hip arthroscopy, which typically includes labral repair and osteoplasty of the femoral neck and/or acetabulum accessed through an interportal capsulotomy. Viewing through an anterolateral portal with use of a 70° scope, a suture-passing device loaded with a #2 FiberWire (Arthrex) is passed down into the mid-anterior portal. The suture is then passed through the anterior aspect of the proximal leaflet of the capsulotomy. The suture-passing device is then passed through the distal leaflet, and the previously passed suture is grasped and brought out of the cannula. The capsular bites are typically made 1 cm from the edge of the capsule. This process is repeated 1.5 cm posteriorly to the initially placed suture. Typical capsular closure takes 2 to 3 sutures for complete closure. Once the sutures are passed, they are tied with use of half-hitches and excess suture is cut.

Alternatives:

Alternatives include capsular plication, which is more frequently performed in the setting of capsular laxity preoperatively or connective-tissue disorders
5,6
. Additionally, there is evidence suggesting that leaving the capsulotomy unrepaired may lead to similar results in select populations
7
.

Rationale:

This procedure is performed largely secondary to the restoration of native anatomy and kinematics of the hip joint
3,8
. Arthroscopy of the hip requires a capsulotomy in order to access the joint, unlike other, more superficial joints such as the shoulder. Capsular closure is often technically challenging and adds length to the procedure. However, recent literature has shown improved patient-reported outcomes with routine capsular closure specifically among high-level athletes
9,10
.

Expected Outcomes:

Routine capsular closure has been associated with good mid-term patient-reported outcomes
10
. Patients who undergo hip arthroscopy and routine capsular closure can expect to meet the minimal clinically important difference and the patient acceptable symptomatic state for the modified Harris hip score and the Hip Outcome Score Activities of Daily Living component. Patients who participate in high-level sports activities may experience a quicker return to play and more normal kinematics with routine capsular closure.

Important Tips:

Clear off the capsule immediately following the capsulotomy.

Utilize an over-the-top view to better visualize the capsule.

Place the sutures from anterior to posterior.
Identification of spatial co-expression patterns and intra-tissue heterogeneity in spatially resolved transcriptomics by region-specific denoising
Authors: Wang Linhua , Liu Zhandong
Published: November 2021

We are pleased to introduce a first-of-its-kind tool that combines in-silico region detection and missing value estimation for spatially resolved transcriptomics. Spatial transcriptomics by 10X Visium (ST) is a new technology used to dissect gene and cell spatial organization. Analyzing this new type of data has two main challenges: automatically annotating the major tissue regions and excessive zero values of gene expression due to high dropout rates. We developed a computational tool—MIST—that addresses both challenges by automatically identifying tissue regions and estimating missing gene-expression values for each detected region. We validated MIST detected regions across multiple datasets using manual annotation on the histological staining images as references. We also demonstrated that MIST can accurately recover ST’s missing values through hold-out experiments. Furthermore, we showed that MIST could identify intra-tissue heterogeneity and recover spatial gene-gene co-expression signals. We therefore strongly encourage using MIST before downstream ST analysis because it provides unbiased region annotations and enables accurately denoised spatial gene-expression profiles.
Research on the Conversion Coefficient for Measuring Radon Concentration in Water Based on Bubbling Method
Authors: Hu Tao , Fan Zhongkai , Lin Fen , Mo Yixiang , Xie Ruomei , Yuan Hongzhi , Wang Luwei , Tan Yanliang
Published: November 2021

Radon is soluble in water, and the radon in drinking water is one of the sources of indoor radon. The China national standard for drinking water (GB5749-2006) indicates that the radon concentration in drinking water cannot be higher than 300pCi/L. The widely used method for measuring radon concentration in water is to use the RAD7 and the H2O accessory which provided by the Durridge Company for bubbling measurement. There are two kind sample bottles: 40ml and 250ml; the measurement steps: bubbling for 5 minutes, and measuring for 20 minutes. For the 40ml sample volume the conversion coefficient is around 25. For the 250ml sample volume the conversion coefficient is around 4. Since the price of the accessory is more than one thousand dollars, and the drying tube of the accessory is small, it needs to be replaced after each measurement which makes the operation is troublesome. We used a big drying tube to perform the radon concentration in water measurement. A new model for description the radon concentration in the gas circuit is proposed, and the conversion coefficient in any measurement condition is obtained. Any volume of sample bottle and drying tube can be used, selecting the suitable bubbling time and measuring time, the radon concentration in water can be obtained.
Machine Health Surveillance System by Using Deep Learning Sparse Autoencoder
Authors: Ullah Faizan , Salam Abdu , Abrar Muhammad , Ahmad Masood , Ullah Fasee , Khan Atif , Alharbi Abdullah , Alosaimi Wael
Published: November 2021

Deep learning is a rapidly growing research area having state of art achievement in various applications including but not limited to speech recognition, object recognition, machine translation, and image segmentation. In the current modern industrial manufacturing system, Machine Health Surveillance System (MHSS) is achieving increasing popularity because of the widespread availability of low cost sensors internet connectivity. Deep learning architecture gives useful tools to analyze and process these vast amounts of machinery data. In this paper, we review the latest deep learning techniques and their variant used for MHSS. We used Gearbox Fault Diagnosis dataset in this paper that contains the sets of vibration attributes recorded by SpectraQuest’s Gearbox Fault Diagnostics Simulator. In addition, the authors used the variant of auto encoders for feature extraction to achieve higher accuracy in machine health surveillance. The results showed that the bagging ensemble classifier based on voting techniques achieved 99% accuracy.
Research-ready data for multi-cohort analyses: The Dementias Platform UK (DPUK) C-Surv data model
Authors: Bauermeister Sarah , Bauermeister Joshua R , Bridgman R , Felici C , Newbury M , North L , Orton C , Squires E , Thompson S , Young S , Gallacher John
Published: November 2021

Research-ready data (that curated to a defined standard) increases scientific opportunity and rigour by integrating the data environment. The development of research platforms has highlighted the value of research-ready data, particularly for multi-cohort analyses. Following user consultation, a standard data model (C-Surv), optimised for data discovery, was developed using data from 12 Dementias Platform UK (DPUK) population and clinical cohort studies. The model uses a four-tier nested structure based on 18 data themes selected according to user behaviour or technology. Standard variable naming conventions are applied to uniquely identify variables within the context of longitudinal studies. The data model was used to develop a harmonised dataset for 11 cohorts. This dataset populated the Cohort Explorer data discovery tool for assessing the feasibility of an analysis prior to making a data access request. It was concluded that developing and applying a standard data model (C-Surv) for research cohort data is feasible and useful.
Zinc Sulfide, Silicon Dioxide, and Black Phosphorus Based Ultra-Sensitive Surface Plasmon Biosensor
Authors: Karki Bhishma , Trabelsi Youssef , Uniyal Arun , Pal Amrindra
Published: November 2021

The optical biosensor is the emerging research area in the field of bio-photonics. The black phosphorus zinc sulfide-based hybrid configuration is suitable for implementing and analyzing ultrasensitive biosensors. Ag/Zinc sulfide/silicon dioxide/black phosphorus-based biosensor has been implemented in the proposed work using the modified Kretschmann configuration. The sensitivity improvement of the designed SPR sensor is analyzed in the different arrangements of the layers. The thickness of the layers of all the materials has been optimized. The thickness of the Ag metal layer is optimized and taken as 45 nm. The sensitivity and quality factor measured here is as high as \(664.6^\circ /\text{R}\text{I}\text{U}\) and 200 at 1.37 refractive index—the P-polarized light source of \(633\text{n}\text{m}\) wavelength. The proposed biosensor confirms tremendous growth in terms of sensitivity, detection accuracy, and quality factor compared with the traditional SPR sensors. Zinc sulfide has multiple applications in the sensing fields, like sensors based on UV rays, lasers, and gas.
Effect of Metal Oxides and Graphene Upon The Electronic Properties of Polyvinyl Alcohol
Authors: Hegazy Maroof A. , Ezzat Hend A. , Yahia Ibrahim S. , Zahran Heba Y. , Elhaes Hanan , Matar Hanan , Ibrahim Medhat
Published: November 2021

Nanomaterials improve the physical and electronic characteristics of polymer matrices, allowing the matrices to be used as low cost, easy to handle sensors. Nano ZnO oxide is forming nanocomposite with PVA modified with graphene. Rather than ZnO other metal oxides are assumed to enhance the electronic properties of PVA modified with graphene (G). Accordingly, Density Function Theory (DFT) was used to analyze model molecules of Polyvinyl Alcohol (PVA) that improved with various metal oxides and graphene quantum dots (GQDs). To show the influence of nanomaterials on PVA matrix behavior, HOMO/LUMO molecular orbitals and Molecular Electrostatic Potential (MESP) mapping were calculated. The B3LYPL/LAN2DZ model was used to calculate the band gap energy ∆E, total dipole moment (TDM), and Molecular Electrostatic Potential (MESP). The obtained results indicated that PVA interacted with MgO, led to a significant improvement in the electrical characteristics. The incorporation of GQDs into PVA/MgO resulted in a novel nanocomposite with good electrical characteristics and a band gap energy ∆E of 0.201 eV, which is intended to be used as a humidity sensor.
Water Magnetization and Application of Soil Amendments Enhance Growth and Productivity of Snapdragon Plants
Authors: Al-Mana Fahed A. , Algahtani Abdullah M. , Dewir Yaser H. , Alotaibi Majed A. , Al-Yafrsi Mohammed A. , Elhindi Khalid M.
Published: November 2021

Freshwater resources are being rapidly depleted because of the increased demand resulting from exponential world population growth and the effects of climate change, especially in arid and semiarid regions (e.g., Saudi Arabia). The present study aimed to examine the changes in growth and inflorescence production of snapdragon (Antirrhinum majus L.) plants in response to irrigation with saline or magnetized water, in addition to application of inorganic and/or organic soil amendments. Three different water types—tap water, magnetized saline water, and nonmagnetized saline water—were used to irrigate A. majus plants with or without soil amendments consisting of ferrous sulfate (Fe2SO4) and/or peatmoss. Irrigation with magnetized saline water adversely affected vegetative growth, inflorescence production, mineral contents, and survival rates of A. majus plants as compared with irrigation with tap water or magnetized saline water. Nevertheless, compared with unmagnetized saline water treatment, magnetizing nonmagnetized saline water before irrigation significantly improved water characteristics and plant growth and survival. Moreover, the addition of inorganic or organic soil amendments enhanced the growth of A. majus plants regardless of irrigation water type. Interestingly, the combination of irrigating with magnetized saline water and soil amendments (Fe2SO4 and peatmoss) significantly enhanced the growth of A. majus plants to a level that was comparable to that of control plants irrigated with tap water without soil amendments. Magnetization improved water quality and increased plants’ ability to absorb water and nutrients from soil solution. The utilization of magnetized saline water for irrigating food and forage crops either alone or in combination with soil amendments has potential benefits that warrant further research.
Experimental studies into the effect of air pressure on the atomization characteristics of coal-water slurries
Authors: Gvozdyakov D. V. , Zenkov A. V. , Gubin V. E. , Kaltaev A. Zh. , Marysheva Ya. V.
Published: November 2021

The paper studies the effect of atomizing agent pressure on the spray characteristics after spraying coal-water slurry that contains small additives of liquid waste from the pyrolysis of industrial rubber goods and used engine oil. The conducted experiments used automobile tires as the indicated rubber products; spraying was carried out employing an internal mixing pneumatic atomizer. Following the atomization of considered fuels, droplet size changes were studied using the interferometric particle imaging (IPI) technique. The spray angle was determined by means of a Photron high-speed camera. In addition, coal-water slurry containing liquid waste from the pyrolysis of industrial rubber goods and used engine oil (3–12 wt%) was sprayed to study the effect of atomizing agent pressure on the spray characteristics. A decrease in air pressure was found to reduce the spray angle by less than 6%, which resulted in the formation of rather large droplets exceeding 600 µm in size. It is experimentally confirmed that more fine droplets are formed at similar fuel and air pressures when using a spraying device equipped with an internal mixing chamber for slurry and air. The number of droplets, in this case, is 2–9% higher as compared to a typical two-component coal-water slurry fuel, with the spray angle of the sprayed coal slurry having the greatest value. When using an atomizer having an internal mixing chamber for slurry and an atomizing agent, fuel droplet breakup occurs due to the aerodynamic drag forces of the environment. Thus, the use of such atomizers reduces the number of possible breakup mechanisms for sprayed fuel droplets.
A review of processing methods for electric arc furnace dust
Authors: Toporkova Yu. I. , Bludova D. , Mamyachenkov S. V. , Anisimova O. S.
Published: November 2021

The work presents an analytical review of processing methods for industrial waste from the ferrous industry, namely, electric arc furnace dust. The annual emissions of this dust and the source of each dust component are determined. Scientific works on the topic of processing electric arc furnace dust published over the past 20 years are compared and analysed. The major methods for dust processing to recover iron, zinc and other metals include pyro - and hydrometallurgical techniques and their combinations. To date, several high-temperature technologies have been developed that allow zinc-containing dust to be efficiently processed (in particular, the Waelz process and secondary processes). However, many of these technologies have remained at the development stage for various reasons (either requiring considerable capital investments, or being unreliable, energy-intensive and inefficient). It is shown that hydrometallurgical processes are environmentally safe and selective to valuable components and allow technological parameters to be controlled. By selecting a suitable solvent (acidic or alkaline), the required metal can be selectively extracted from dust. In addition, such a technology will be cost-effective even under low contents of the extracted component. Approaches to processing metallurgical dust with inorganic and organic acids and ammonia-based solutions are described. Both conventional processing of electric arc furnace dust on an industrial scale and the laboratory developments recently introduced at zinc production plants (their features, advantages and disadvantages) are discussed. Technologies that allow valuable components in the dust to be extracted and returned to the production cycle are identified.
Assessment of xenon effect on postoperative pain syndrome severity in oncological patients: a randomized study
Authors: Potievskaya Vera I. , Shvetskiy F. M. , Sidorov D. V. , Lozhkin M. V. , Potievskiy M. B. , Abuzarova G. R. , Sarmanaeva R. R. , Kuznetsov S. V. , Alekseeva G. S.
Published: November 2021

Introduction. The present study was designed to evaluate analgetic effect of xenon-oxygen mixture inhalations in oncological patients with abdominal tumors in postoperative period. Materials and methods. It was randomized blind placebo-controlled clinical trial, which was performed in 60 patients: 31 of them were in the main group and received xenon-oxygen mixture containing 25 ± 5 % xenon and other 29 were in the placebo group and received oxygen-air mixture. Results. According to the visual-analogical scale of pain, significant decreasing of the pain level was found in the main group after the inhalation and 30 minutes later in 90.3 % (p < 0.01) and 80.6 % of patients (p < 0.05) accordingly. The same result was found in the placebo group in 37.9 % of patients after oxygen-air mixture inhalation and 30 minutes later in 27.4 % of patients. The pain threshold measured with transcutaneal electroneurostimulation significantly increased in the xenon group after the inhalation (p < 0.01) and 30 minutes later (p < 0.05). In the placebo group no difference between the measurements was found. Conclusions. Xenon-oxygen mixture inhalation leads to the postoperative pain level reduction and increases the pain threshold in oncological patients.
Analytic conformal bootstrap and Virasoro primary fields in the Ashkin-Teller model
Authors: Nemkov Nikita , Ribault Sylvain
Published: November 2021

We revisit the critical two-dimensional Ashkin–Teller model, i.e. the
\mathbb{Z}_2ℤ2
orbifold of the compactified free boson CFT at
c=1c=1.
We solve the model on the plane by computing its three-point structure
constants and proving crossing symmetry of four-point correlation
functions. We do this not only for affine primary fields, but also for
Virasoro primary fields, i.e. higher twist fields and degenerate fields.
This leads us to clarify the analytic properties of Virasoro conformal
blocks and fusion kernels at c=1c=1.
We show that blocks with a degenerate channel field should be computed
by taking limits in the central charge, rather than in the conformal
dimension. In particular, Al. Zamolodchikov’s simple explicit expression
for the blocks that appear in four-twist correlation functions is only
valid in the non-degenerate case: degenerate blocks, starting with the
identity block, are more complicated generalized theta functions.
Classification of BINUS University Student Organizations’ Logos from the Perspective of Visual Construction
Authors: Sonia Candi Reggi , Lakonawa Petrus
Published: November 2021

This research focuses on the classification of BINUS University student organizations’ logo using textual qualitative approach. It aims at analyzing how they chose the shape of the logo in order to express their identity. This research is framed by three significant focal points in view of its construction namely, the combination of picture mark and letter mark, the integration of picture mark within letter mark or vice versa, and letter mark only. The result of this research shows that the officials of the organizations tend to choose logo that has aesthetic quality in simple visual form rather than complicated one. This research also closely observes the making process of the logo and its classification up to its final appointment as the official logo of the student organizations.
Poverty Alleviation of Women through Development of Cottage Industry in Cilegon Municipality, Banten
Authors: Muslikhin Muslikhin
Published: November 2021

This study aims to describe the implementation of the program of Cottage Industry (Industri Rumahan) in Cilegon Municipalty, Banten.  Development of Cottage Industry (IR) is a program initiated by Kementerian Pemberdayaan Perempuan dan Perlindungan Anak (KPPPA). The program will run for three years from 2016 to 2018. For 2016, the program is implemented in 14 districts and municipalities, one of which is Cilegon Municipality, Banten. Data collection is done by interviewing IR perpetrators and assistants. In addition, the data was collected by analyzing the documents such as the records of the implementing team meetings, the companion worker reports, mapping reports and mapping results analysis in the two urban villages that were the locations of IR development implementation. The validity test of data is done by triangulation of source and method.The study concluded that in general the implementation of IR development program in Cilegon Municipality, namely in Villages Ketileng and Bandengan, has followed the development pattern established by KPPPA. It's just that in some stages is not working properly. The stages that have problems are when determining the number of IR actors who get help and production equipment distribution. Many IR actors protest that they are not included in the IR development program. In addition to the production equipment that is distributed to IR actors, some are not in accordance with their needs so that less than the maximum.
TOEFL Preparation for University Students’ Candidates from ASAK Paroki MKK
Authors: Herina Clara
Published: November 2021

Some private universities in Jakarta use TOEFL or TOEFL-like test as the admission requirement for new students.  Therefore, students’ candidates should prepare well to achieve the minimum score for being admitted. Unfortunately, their high school did not give enough training in doing the TOEFL test. The purpose of this community development program is to train high school students to do TOEFL test, especially the Reading section.  The participants of the program were seven 12th grade high school students who were included in ASAK Paroki MKK community.  They were trying to qualify for admission in Binus University.  The program was created in the form of classroom teaching and individual assignment.  In this program, we taught them about the TOEFL Reading test types, strategies, and tips for doing the test.  After the training, the students reported their understanding of TOEFL and confidence in preparing the university admission test.
Comparação de Algoritmos para Detecção de Nadadores Visando Automação de um Veículo Elétrico
Authors: Assis Lucas Correa , Freire Roberto Zanetti
Published: November 2021

Na análise biomecânica de nadadores, o uso de câmeras vem contribuindo para a melhora de rendimento esportivo. Porém grande parte dos vídeos são gravados de forma manual. Este trabalho tem como objetivo realizar uma análise comparativa entre os algoritmos de aprendizado profundo, YOLO v4 e YOLO v4 Tiny, para detecção de nadadores, visando o projeto de um veículo capaz de seguir, de forma autônoma, os atletas ao longo da piscina. O treinamento dos algoritmos foi realizado com a base de dados Video Diver Dataset (VDD-C), que contém imagens anotadas de mergulhadores em piscinas e na costa de Barbados no Caribe. Para comparação entre os algoritmos, levou-se em consideração qualidade e tempo de detecção, baseando-se nas métricas de Average Intersection Over Union (IoU), Recall, Average Precision (AP) e tempo de latência. O algoritmo YOLO v4, apresentou superioridade na qualidade de detecção, atingindo 71,38% de Average IoU. Porém a YOLO v4 Tiny, apresentou um tempo de latência 6,93 vezes menor, mostrando ser uma opção para sistemas embarcados e aplicações em tempo real.
Otimização de Rotas Logísticas por meio da abordagem Team Orienteering Problem baseada em metaheurística GRASP e Path Relinking
Authors: Funk Tiago , Fiorese Adriano , Baldo Fabiano
Published: November 2021

Na logística de entregas um dos maiores desafios e a elaboração das rotas dos veículos que minimize os deslocamentos e seja realizada em tempo aceitável. Uma abordagem para a otimização do roteamento é a baseada na solução do problema Team Orienteering Problem (TOP). Entretanto, assim como o TSP, o TOP também é um problema de complexidade computacional NP-Hard. Portanto, deve ser resolvido com o auxílio de abordagens metaheurísticas. Nesse sentido, este trabalho apresenta uma abordagem de solução do TOP enquadrada para problemas de otimização de rotas logísticas. Tal abordagem visa o desenvolvimento de um algoritmo baseado na metaheurística GRASP conjugada com a técnica de intensificação de resultados Path Relink. Os resultados alcançados demonstram que algoritmo proposto alcançou os resultados encontrados na literatura para 46,5% das instâncias executadas, indicando resultados promissores para um trabalho em desenvolvimento.
Deep Rule-Based Approach for the Classification of Wagon Bogie Springs Condition
Authors: Viriato Neto Carlos Manuel , Honorio Luca Garcia , Aguiar Eduardo
Published: November 2021

This paper focuses on the new model of classification of wagon bogie springs condition through images acquired by a wayside equipment. As such, we are discussing the application of a deep rule-based (DRB) classifier learning approach to achieve ahigh classification of a bogie, and check if they either have spring problems or not. We use a pre-trained VGG19 deep convolutional neural network to extract the attributes from images to be used as input to the classifiers. The performance is calculated based on the data set composed of images provided by a Brazilian railway company. The presented results of the report demonstrate the relative performance of applying the DRB classifier to the questions raised.
Estimation of Radial Basis Function Network Centres via Informational Forces
Authors: Sousa Júnior Edilson , Freitas Airton Carneiro , Rabelo Ricardo , Santos Welflen
Published: November 2021

The Radial Basis Function Network centres determination is a open problem. In this work, the cluster centres are determined by a proposed gradient algorithm using the information forces acting on each data point. These centres are applied to a Radial Basis Function Network for data classification. A threshold is established based on Information Potential to classify the outliers. Combined, the threshold and the centres determined by information forces show good results in comparison to a similar Network with a k-means clustering algorithm.
Removal of arsenic from polluted water through adsorption onto selected soil
Authors: Wu Wenzhu , Guo Min , Shi Lili , Zhou Yueguang
Published: November 2021

An arsenic-contamination survey was conducted in Lake Datunhai in Southwest China, which is contaminated by arsenic. The arsenic-contaminated soil was selected and arsenic adsorption on the soil solid in the polluted water was studied through field investigation and laboratory experiments. The results showed that the red soil in survey area contained a relatively large amount of arsenic in the range of 36.41–153.52 mg/kg, which is higher than the National Soil Environmental Quality Standard Grade III. The arsenic pollution in the surveyed lake was relatively serious, as the amount of arsenic contained in the water of Lake Datunhai was between 0.23 and 0.663 mg/L. The amount of arsenic in the sediment was between 273 and 755 mg/kg. The results of laboratory adsorption experiments with different soils showed that when the ratio of soil and water was 3.5/1000, the amount of arsenic in the water sample taken from the lake reduced from 0.3 mg/L to 0.03 mg/L, which would satisfy the Water Quality Standard Grade III (below 0.05 mg/L). The selected red soil was relatively effective for arsenic absorption. Based on theoretical calculations, the thickness of sediment would increase by about 0.95 cm by applying fixed arsenic solid on arsenic-polluted water treatment.
Increased Expression of Recombinant Chitosanase by Co-expression of
Hac1p in the Yeast Pichia pastoris
Authors: Han Minghai , Wang Weixian , Gong Xun , Zhou Jianli , Xu Cunbin , Li Yinfeng
Published: November 2021

Background:

Pichia pastoris is one of the most popular eukaryotic hosts for producing
heterologous proteins, while increasing the secretion of target proteins is still a top priority for their
application in industrial fields. Recently, the research effort to enhance protein production has focused
on up-regulating the unfolded protein response (UPR).

Objective:

We evaluated the effects of activated UPR via Hac1p co-expression with the promoter
AOX1 (PAOX1) or GAP (PGAP) on the expression of recombinant chitosanase (rCBS) in P. pastoris.

Method:

The DNA sequence encoding the chitosanase was chemically synthesized and cloned into
pPICZαA, and the resulting pPICZαA/rCBS was transformed into P. pastoris for expressing rCBS.
The P. pastorisHAC1i cDNA was chemically synthesized and cloned into pPIC3.5K to give
pPIC3.5K/Hac1p. The HAC1i cDNA was cloned into PGAPZB and then inserted with the HIS4
gene from pAO815 to construct the vector PGAPZB/Hac1p/HIS4. For co-expression of Hac1p, the
two plasmids pPIC3.5K/Hac1p and PGAPZB/Hac1p/HIS4 were transformed into P. pastoris harboring
the CBS gene. The rCBS was assessed based on chitosanase activity and analyzed by SDSPAGE.
The enhanced Kar2p was detected with western blotting to evaluate UPR.

Results:

Hac1p co-expression with PAOX1 enhanced rCBS secretion by 41% at 28°C. Although
the level of UPR resulting from Hac1p co-expression with PAOX1 was equivalent to that with
PGAP in terms of the quantity of Kar2p (a hallmark of the UPR), substitution of PGAP for PAOX1
further increased rCBS production by 21%. The methanol-utilizing phenotype of P. pastoris did
not affect rCBS secretion with or without co-expression of Hac1p. Finally, Hac1p co-expression
with PAOX1 or PGAP promoted rCBS secretion from 22 to 30°C and raised the optimum induction
temperature.

Conclusion:

The study indicated that Hac1p co-expression with PAOX1 or PGAP is an effective
strategy to trigger UPR of P. pastoris and a feasible means for improving the production of rCBS
therein.
An Overview on Functional and Structural Properties of Monomeric and
Multimeric β-Thymosin in Invertebrates
Authors: Gao Lili , Huang Mujie , Deng Hongkuan , Pang Qiuxiang
Published: November 2021

:

β-thymosin 4 (Tβ4) is a prototypical actin-monomer sequestering protein that plays an
important role in mammalian cells and tissues. In vertebrates, Tβ4 is involved in various physiological
and pathophysiological processes, such as angiogenesis, hair follicle and hair regeneration, nervous
system development, inflammatory response, wound healing, tumour metastasis, and liver
and heart protection. Additionally, thymosin domain-containing protein was discovered in invertebrates
and was recently shown to be more homologous to Tβ4. However, the structural and functional
properties are more complex and diverse than those of Tβ4. In this review article, we will discuss
in detail the structural and functional aspects of β-thymosin in invertebrates.
Thymoquinone Lipid Nanoparticles Cut the Gordian Knots of Depression via Neuroprotective
BDNF and Downregulation of Neuro-inflammatory NF-κB, IL-6, and
TNF-α in LPS Treated Rats
Authors: Alam Mahtab , Javed Md. Noushad , Najmi Abul Kalam , Ahmad Farhan Jalees , Imam Syed Sarim , Akhtar Mohd
Published: November 2021

Background:

In over 300 million clinical cases, antidepressant drugs seem to provide only symptomatic
relief and limited protection in life-threatening depressive events.

Objective:

To compare neuronal-signaling mechanism and neuroprotective roles of Thymoquinone (TQ) suspension
and its SLN (TQSLN) against standard antidepressant drug fluoxetine.

Methods:

This research investigated in-silico docking at NF-KB p50 active site, CLSM based gut permeation,
screening of antidepressant activities and neurosignaling pathways involved.

Results:

As compared to fluoxetine, TQ reporteda significantly better docking score (-6.83 v/s -6.22) and a better
lower free binding energy of (-34.715 Kcal/mol v/s -28.537 Kcal/mol). While poorly oral bioavailable and P-gp
substrate TQ reported approximately 250% higher gut permeation if delivered as TQSLN formulation. In locomotor
studies, as compared to TQS, TQSLN favored more prominent (p< 0.010) elevation in average time, horizontalactivity,
average-velocity, and total-movement with reduced rest time LPS treated groups. However, in the tail suspension
test, TQSLN significantly reduced immobility time (p<0.010). Similarly, In the modified force swimming
test, TQSLN also significantly reduced immobility time (p<0.010), but swimming time (p<0.010) and climbing time
(p<0.050) were significantly elevated. Subsequently, TQSLN reported significantly elevated neuroprotective BDNF
(p<0.010) as well as hippocampal 5HT/TRP; accompanied with reduced levels of hippocampal inflammatory markers
TNF-α (p<0.001) and IL-6 (p<0.010) as well as lower kynurenine and tryptophan ratio (KYN/TRP). Similarly,
the hippocampal CA1 region further revealed TQSL more predominantly attenuated NF-kB nuclear translocation in
the brain.

Conclusion:

Despite the poor bioavailability of TQ, TQSLN potentially attenuates neuroinflammatory transmitters
and favors BDNF to modulate depressive neurobehavioral states.
High-resolution MD Simulation Studies to Get Mechanistic Insights into the Urea-induced Denaturation of Human Sphingosine Kinase 1
Authors: Khan Faez Iqbal , Ali Shahid , Chen Wenjing , Anjum Farah , Shafie Alaa , Hassan Md. Imtaiyaz , Lai Dakun
Published: November 2021

Background:

Sphingosine kinase 1 (SPhK1) is a crucial signaling enzyme involved in
cell proliferation, cellular survival, stimulation of angiogenesis, and apoptosis prevention. Recently,
we have reported the unfolding kinetics of SPhK1 using molecular dynamics (MD) simulation,
circular dichroism, and fluorescence spectroscopy. We found that SPhK1 showed a biphasic unfolding
with an intermediate state (~ 4.0 M urea).

Objective:

We aim to understand the impact of MD simulation duration on the structure, function,
and dynamics of proteins. In order to get deeper insights into the folding mechanism, an extended
MD simulation is required.

Method:

Here, we extended the MD simulations time scale from 100 to 300 ns on SPhK1 at increasing
urea concentration to explore structural changes in the SPhK1.

Results:

The results suggested a constant form of the unfolding of SPhK1 upon extending the simulation
time scale at different urea concentrations. Furthermore, we showed step by step unfolding
and percentage of secondary structure contents in SPhK1 under the influence of urea at each concentration.

Conclusion:

The results from the current work revealed a uniform pattern of the SPhK1 unfolding
at different urea concentrations. This study provides deeper mechanistic insights into the urea-induced
denaturation of SPhK1.
Ovine COX-1 Isoenzyme Bio-production
Authors: Perrone Maria Grazia , Scilimati Antonio , Miciaccia Morena , Iaselli Mariaclara , Ferorelli Savina , Loguercio Polosa Paola
Published: November 2021

Background:

Recent findings enlightened the pivotal role of cyclooxygenases-1 and -2
(COX-1 and COX-2) in human diseases with inflammation as the committed earliest stage, such as
cancer and neurodegenerative diseases. COXs are the main targets of nonsteroidal anti-inflammatory
drugs and catalyze the bis-oxygenation of arachidonic acid into prostaglandin PGH2, then converted
into prostaglandins, thromboxane, and prostacyclin by tissue-specific isomerases. A remarkable
amount of pure COX-1 is necessary to investigate COX-1 structure and function, as well as for in vitro
disease biochemical pathway investigations.

Methods:

Spodoptera frugiperda cells were infected with Baculovirus that revealed to be an efficient
expression system to obtain a high amount of ovine(o)COX-1. Protein solubilization time in the presence
of a non-ionic detergent was modified, and a second purification step was introduced.

Results and Discussion:

An improvement of a previously reported method for pure recombinant
oCOX-1 production and isolation has been achieved, leading to a lower starting volume of infected
cells for each purification, an increased cell density, an increased number of viral particles per cell,
and a shortened infection period. The protocol for the recombinant oCOX-1 expression and purification
has been in-depth elaborated to obtain 1 mg/L of protein.

Conclusion:

The optimized procedure could be suitable for producing other membrane proteins as
well, for which an improvement in the solubilization step is necessary to have the availability of high
concentration proteins.
Intangible cultural heritage as a resource for consolidating modern Ukrainian society
Authors: Chmil Hanna , Kuznietsova Inna , Mishchenko Maryna , Oliynyk Oleksandra , Demeshchenko Violeta
Published: November 2021

The relevance of this study lied in actualising the issue of increasing the level of social consolidation of Ukrainian society under the conditions of a number of political, economic, social, and cultural transformations. Intangible cultural heritage serves as the main resource for the establishment and development of national consciousness, which, in turn, strengthens integration processes within society. The purpose of the study is to prove the value of intangible cultural heritage in the modern life of Ukrainians and substantiate the need to preserve cultural values in the course of historical development as a powerful ethno-unifying factor. In the course of the study, general scientific methods, namely analysis, synthesis, induction, deduction, systematic, and comparative were used for logical and consistent presentation of the material. A critical approach to information allowed comprehensively and thoroughly examining the issue of cultural heritage as a unifying factor. As a result of the study, it was discovered that due to complex socio-political and globalisation processes, there is still a need to preserve the traditional heritage, which is an indicator of cultural independence, proving the uniqueness and originality of each nation. Therefore, in the course of the technologisation of society.
Exercise and Nutritional Strategies to Promote Weight Loss: A Narrative Review
Authors:   Exercise and Sport Nutrition Lab, Human Clinical Research Facility, Department of Health & Kinesiology, Texas A&M University, College Station, Texas, USA, Kreider Richard B.
Published: November 2021

Obesity has historically been thought to simply be related to an imbalance between energy intake and expenditure. Weight loss recommendations have traditionally focused on reducing energy intake, maintaining either a high-carbohydrate low-fat diet or vice versa, and increasing physical activity typically through low to moderate intensity exercise. More recently, genetic, physiological, and behavioral factors have also been found to play a significant role in the etiology of obesity. For this reason, the prevention and management of obesity through implementation of different types of exercise and diet intervention programs, behavioral interventions, and/or medical interventions are at the forefront of obesity research. As a result, we are beginning to see a paradigm shift from traditional weight loss and management approaches to personalized diet and exercise strategies. This purpose of this narrative review was to overview: 1.) the effects of physical activity on weight loss; 2.) the effects of diet and cardiovascular exercise on weight loss; 3.) the effects of high protein diet with resistance-exercise on weight loss; and, 4.) behavioral factors that contribute weight loss and maintenance.