bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the association between PITX2, third molars agenesis and sella turcica morphology
Authors: Küchler Erika Calvano , de Melo Teixeira do Brasil Jordanna , Madalena Isabela Ribeiro , Proff Peter , Baratto-Filho Flares , Alam Mohammad Khursheed , Schroder Angela Graciela Deliga , Lepri César Penazzo , Kirschneck Christian , de Menezes-Oliveira Maria Angélica Hueb
Published: February 2024

Objectives

PITX2 is required for mammalian development and single nucleotide polymorphisms (SNPs) in this gene could be involved in dental agenesis and sella turcica patterns. Thus, the present study evaluated the association between SNPs in PITX2, third molars agenesis and sella turcica phenotypes.

Materials and methods

The sample consisted of healthy orthodontic German patients with lateral cephalometric radiographs with clearly visualization of the sella turcica, and dental orthopantomograms. The morphological variations of the sella turcica were evaluated using the lateral cephalograms, while third molar agenesis was evaluated using orthopantomograms. DNA isolated from buccal cells was used for genotyping three SNPs in PITX2 (rs3796902, rs1947187, and rs2595110). The analyzes were performed using a significance of 5%. There was no association between third molar agenesis and sella turcica phenotypes (p > 0.05). SNPs in PITX2 were also not associated with third molars agenesis (p > 0.05).

Results

SNPs in PITX2 were associated with sella turcica phenotypes. The rs3796902 was associated with hypertrophic posterior clinoid process (p = 0.013). The rs1947187 and rs2595110 were associated with sella turcica bridge type A (p = 0.013 and p = 0.011, respectively for genotype distribution). Patients that carry the genotypes GG-CC-AG (rs3796902- rs1947187- rs2595110) had 7.2 higher chance to present sella turcica bridge type A (p = 0.002; Odds ratio = 7.2, Confidence interval 95% 2.04–27.04).

Conclusions

Third molar agenesis was not associated with SNPs in PITX2 and sella turcica phenotypes. SNPs in PITX2 may have an important role in sella turcica pattern.
An open-source controller to build a dynamic light intensity setup
Authors: Caracciolo Ludovico , Philippi John , Theeuwen Tom P. J. M. , van Amerongen Herbert , Harbinson Jeremy
Published: February 2024

Background

The development and physiology of plants are influenced by light intensity and its changes. Despite the significance of this phenomenon, there is a lack of understanding regarding the processes light regulates. This lack of understanding is partly due to the complexity of plant’s responses, but also due to the limited availability of light setups capable of producing specific light patterns.

Results

While unraveling the complexities of plant responses will require further studies, this research proposes a simple method to implement dynamic light setups. In this study, we introduce two distinct electronic circuits that are cost-effective and enable the control of a dimmable power supply.

Conclusion

This method enables the generation of intricate light patterns and rapid intensity fluctuations, providing a means to investigate how plants respond and develop when exposed to dynamic light conditions.
Predictive value of delta radiomics in xerostomia after chemoradiotherapy in patients with stage III-IV nasopharyngeal carcinoma
Authors: Wang Mengze , Xi Yuzhen , Wang Luoyu , Chen Haonan , Jiang Feng , Ding Zhongxiang
Published: February 2024

Background

Xerostomia is one of the most common side effects in nasopharyngeal carcinoma (NPC) patients after chemoradiotherapy. To establish a Delta radiomics model for predicting xerostomia secondary to chemoradiotherapy for NPC based on magnetic resonance T1-weighted imaging (T1WI) sequence and evaluate its diagnostic efficacy.

Methods

Clinical data and Magnetic resonance imaging (MRI) data before treatment and after induction chemotherapy (IC) of 255 NPC patients with stage III-IV were collected retrospectively. Within one week after CCRT, the patients were divided into mild (92 cases) and severe (163 cases) according to the grade of xerostomia. Parotid glands in T1WI sequence images before and after IC were delineated as regions of interest for radiomics feature extraction, and Delta radiomics feature values were calculated. Univariate logistic analysis, correlation, and Gradient Boosting Decision Tree (GBDT) methods were applied to reduce the dimension, select the best radiomics features, and establish pretreatment, post-IC, and Delta radiomics xerostomia grading predictive models. The receiver operating characteristic (ROC) curve and decision curve were drawn to evaluate the predictive efficacy of different models.

Results

Finally, 15, 10, and 12 optimal features were selected from pretreatment, post-IC, and Delta radiomics features, respectively, and a xerostomia prediction model was constructed with AUC values of 0.738, 0.751, and 0.843 in the training set, respectively. Only age was statistically significant in the clinical data of both groups (P < 0.05).

Conclusion

Delta radiomics can predict the degree of xerostomia after chemoradiotherapy for NPC patients and it has certain guiding significance for clinical early intervention measures.
The ground is the limit: epidemiology of skydiving accidents over 25 years and in 2.1 million jumps in the Netherlands with sub-analysis of injuries reported by medical professionals in the past five years
Authors: Damhuis Michiel , van der Wal Raymond , Frielink Harriet , Nijveldt Robert , ten Brinke Joost , Tan Edward
Published: February 2024

Background

Skydiving is the fastest nonmotorized sport; and consequently is not without risk. In the last decades, skydiving has become considerably safer but injuries and fatalities still occur. Incidents are reported to and administered by the Royal Netherlands Aeronautical Association (KNVvL). From 1995 to 2020, 2715 incidents were reported; of which 1503 resulted in injury and 26 in fatality. There is a need for more information available on the particular type, severity, and factors which contribute to skydiving-related injuries worldwide. This study aims to investigate patterns in occurrence rates, examine demographic and skydiving-related factors linked to injuries, and analyze the types and severity of injuries relating to these contributing factors.

Methods

The Dutch KNVvL database – covering more than 25 years of data – was examined for contributing factors. An analysis of the severity and types of injury resulting from incidents over the last five years were matched with a search of hospital databases.

Results

The rate of injuries pattern increases starting from 2016, with novice jumpers having the highest risk of injury. Most injuries occur during the landing phase. The lower extremities and the spine are most affected, with fractures being the most prevalent type of injury. More than half of the patients were admitted to hospital, with 10% requiring surgery, resulting in months of rehabilitation.

Conclusion

This study is the first in the Netherlands, and only the second worldwide to analyze technical incident databases in combination with data from medical information systems. Skydiving accidents of experienced jumpers should be considered as ‘high-energy trauma,’ therefore treatment should follow standard trauma guidelines. In less experienced skydivers, it is critical to conduct a secondary survey to assess the extremities adequately. Clinicians should also pay attention to friction burns that can arise due to friction between the skin and skydive equipment, a phenomenom that is already known in road traffic accidents.
Preoperative multimodal ultrasonic imaging in a case of Peutz-Jeghers syndrome complicated by atypical lobular endocervical glandular hyperplasia: a case report and literature review
Authors: Yang Liwen , Duan Duan , Xiong Ying , Liu Tianjiao , Zhao Lijun , Lai Fan , Gu Dingxian , Zhou Liuying
Published: February 2024

Background

Peutz-Jeghers syndrome (PJS), an autosomal dominant multiple cancerous disorder, is clinically characterized by mucocutaneous macules and multiple gastrointestinal hamartomatous polyps. Gastric-type endocervical adenocarcinoma (G-EAC), a special subtype of cervical adenocarcinoma with non-specific symptoms and signs, is known to occur in approximately 11% of female patients with PJS.

Case presentation

Here, we report a case of PJS in a 24-year-old female with multiple mucocutaneous black macules who complained of vaginal discharge and menorrhagia. Moreover, we first described the multimodal ultrasonographical manifestations of PJS-correlated G-EAC. The three-dimensional reconstructed view of G-EAC on 3D realisticVue exhibited a distinctive “cosmos pattern” resembling features on magnetic resonance imaging, and the contrast-enhanced ultrasound displayed a “quick-up and slow-down” pattern of the solid components inside the mixed cervical echoes. We reported the multimodal ultrasonographical characteristics of a case of PJS-related G-EAC, as well as reviewed PJS-related literature and medical imaging features and clinical characteristics of G-EAC to provide insight into the feasibility and potential of utilizing multimodal ultrasonography for the diagnosis of G-EAC.

Conclusions

Multimodal ultrasound can visualize morphological features, solid components inside, and blood supplies of the G-EAC lesion and distinguish the G-EAC lesion from normal adjacent tissues. This facilitates preoperative diagnosis and staging of PJS-related G-EAC, thereby aiding subsequent health and reproductive management for patients with PJS.
Co-occurrence of habit-forming risk behaviors and their socio-demographic, health status and lifestyle determinants: a population-based cross-sectional study
Authors: Kose Junko , Duquenne Pauline , Hercberg Serge , Galan Pilar , Touvier Mathilde , Fezeu Léopold K. , Andreeva Valentina A.
Published: February 2024

Background

Although habit-forming risk behaviors frequently co-occur, determinants of concurrent risk behaviors have rarely been investigated. The aim of the present study was to investigate socio-demographic, health status, and lifestyle determinants of single versus concurrent risk behaviors in general-population adults.

Methods

We analyzed data from 32,622 participants (74.5% female; mean age = 57.9 ± 14.2 years) of the NutriNet-Santé cohort who completed the Alcohol Use Disorders Identification Test, the 12-item Cigarette Dependence Scale, the modified Yale Food Addiction Scale 2.0, and the Internet Addiction Test in 2021–2022. Using established cutoffs, participants were first split into 2 groups (presence versus absence) for each risk variable (alcohol use disorders, nicotine dependence, food addiction, Internet addiction) and were then divided into 3 groups (no risk behavior, 1 risk behavior (reference), and ≥ 2 risk behaviors). The association between socio-demographic, health status, and lifestyle exposures and individual/concurrent risk behaviors were investigated with polytomous logistic regression.

Results

Younger age (Odds Ratio (OR) = 2.04; 95% Confidence Interval (CI: 1.62–2.56), current financial difficulties (OR = 1.29; CI: 1.08–1.54), self-perceived poor health (OR = 1.70; CI: 1.32–2.20), overall poor dietary quality (OR = 2.88; CI: 2.06–4.02), being underweight (OR = 1.46; CI: 1.05–2.04), having obesity (OR = 1.62; CI: 1.31–1.99), lack of affection during childhood (OR = 1.41; CI: 1.18–1.69), and a lifetime prevalence or medication use for a mental disorder (OR = 1.46; CI: 1.24–1.73) were positively associated with having ≥ 2 versus 1 risk behavior (all p < 0.05). The comparison of none versus 1 risk behavior revealed the same determinants in addition to having a higher education, being physically active at work, and being overweight.

Conclusions

We investigated determinants of concurrent habit-forming risk behaviors among adults in a large, population-based study. The findings could serve as impetus for future research in this domain and ultimately help guide addiction prevention efforts.
An Updated Review on the Effect of CFRP on Flexural Performance of Reinforced Concrete Beams
Authors: Jahami Ali , Issa Camille A.
Published: February 2024

This detailed review looks at how carbon fiber-reinforced polymer (CFRP) may be used to improve the flexural capacity of reinforced concrete (RC) beams. It investigates the history, characteristics, and research trends of FRP composites, assesses various flexural strengthening methods utilizing FRP, and addresses the predictive power of finite-element (FE) modeling. The assessment highlights the importance of enhanced design codes, failure mode mitigation, and improved predictive modeling methodologies. It emphasizes the advantages of improving FRP reinforcement levels to meet code expectations and covers issues, such as FRP laminate delamination and debonding. The findings highlight the need of balancing load capacity and structural ductility, as well as the importance of material behavior and failure processes in accurate prediction. Overall, this review offers valuable insights for future research and engineering practice to optimize flexural strengthening with CFRP in RC beams.
Pragmatic Return to Effective Dental Infection Control through Triage and Testing (PREDICT): an observational, feasibility study to improve dental office safety
Authors: Fredericks-Younger Janine , Feldman Cecile A. , Allareddy Veerasathpurush , Funkhouser Ellen , McBurnie MaryAnn , Meyerowitz Cyril , Ragusa Pat , Chapman-Greene Julie , Coker Modupe , Fine Daniel , Gennaro Maria Laura , Subramanian Gayathri
Published: February 2024

Background

During the COVID-19 pandemic, there was a substantial interruption of care, with patients and workers fearful to return to the dental office. As dental practice creates a highly aerosolized environment, the potential for spread of airborne illness is magnified. As a means to increase safety and mitigate risk, pre-visit testing for SARS-CoV-2 has the potential to minimize disease transmission in dental offices. The Pragmatic Return to Effective Dental Infection Control through Testing (PREDICT) Feasibility Study examined the logistics and impact of two different testing mechanisms (laboratory-based PCR viral testing and point-of-care antigen testing) in dental offices.

Methods

Dental healthcare workers (DHCWs) and patients in four dental offices within the National Dental Practice-based Research Network participated in this prospective study. In addition to electronic surveys, participants in two offices completed POC testing, while participants in two offices used lab-based PCR methods to detect SARS-CoV-2 infection. Analysis was limited to descriptive measures, with median and interquartile ranges reported for Likert scale responses and mean and standard deviation for continuous variables.

Results

Of the total 72 enrolled, 28 DHCWs and 41 patients completed the protocol. Two patients (4.9%) tested positive prior to their visit, while 2 DHCWs (12.5%) tested positive for SARS-CoV-2 infection at the start of the study. DHCWs and patients shared similar degree of concern (69% and 63%, respectively) for contracting COVID-19 from patients, while patients feared contracting COVID-19 from DHCWs less (49%). Descriptive statistics calculations revealed that saliva, tongue epithelial cells, and nasal swabs were the most desirable specimen collection method; both testing (LAB and POC) protocols took similar amounts of total time to complete; and DHCWs and patients reported feeling more comfortable when both groups were tested.

Conclusions

While a larger-scale, network study is necessary for generalizability of results, this feasibility study suggests that SARS-CoV-2 testing can be effectively implemented into dental practice workflows and positively impact perception of safety for DHCWs and patients. As new virulent infectious diseases emerge, preparing dental personnel to employ an entire toolbox of risk mitigation strategies, including testing, may have the potential to decrease dental practice closure time, maintaining continuity of dental care services for patients.

Trial registration

ClinicalTrials.gov: NCT05123742.
Innocence and danger at the border: migrants, “Bad” mothers, and the nation’s protectors
Authors: Parsons John R. , Riva Sara
Published: February 2024

Media and political discourse in the USA often depict migration as an invasion and people who cross borders as criminals dangerous to the nation. Through ethnographic fieldwork conducted in two places on the USA-Mexico Southern border, we want to analyze how invasion narratives influence practices on-the-ground. We first explore how these narratives inform the views of a border militia who see themselves as protectors of the nation and understand people who cross borders as threats. We then argue that migrant women’s presence in areas where the militia operates disrupts the dominant narrative that defines migrants as dangerous, as militia members come to understand migrant women as victims of the Cartel. Despite their innocence, to maintain the narrative’s consistency, militia members still consider migrant women criminals for crossing the border “illegally.” Finally, we move on to explore the materiality of these xenophobic discourses by examining how migrant women are mistreated at a family immigration detention center. Using the militias as an example, we highlight why political narratives circulate and have meaning for individuals and how discourses have material consequences.
Patient satisfaction and their determinants in outpatient department of a tertiary public hospital in Nepal: a cross-sectional study
Authors: Bhatt Laxman Datt , Ghimire Sandhaya , Khanal Kabita
Published: February 2024

Background

Patient satisfaction is a vital metric for assessing healthcare quality and delivering patient-centered care. It can predict service utilization patterns by determining healthcare users’ contentment with their providers. Consequently, evaluating patient satisfaction and its underlying factors is crucial to maintaining the quality of healthcare services. The present study aimed to assess patient satisfaction and its determinants in a tertiary care public hospital in Nepal. In this research, a cross-sectional design was employed to examine patient satisfaction within the Outpatient Department of Mental Hospital Lagankhel, Nepal. The study adopted a systematic random sampling approach for respondent selection, and stringent measures were implemented to uphold the validity and reliability of the collected data. To assess patient satisfaction comprehensively, the Patient Satisfaction Questionnaire-III (PSQ-III), developed by the RAND Corporation, was employed in conjunction with relevant sociodemographic variables. Utilizing mean scores and percentages, we calculated satisfaction levels across various dimensions. Additionally, a multinomial logistic regression analysis was conducted to investigate the relationships between patient satisfaction dimensions and sociodemographic characteristics.

Results

This study encompassed perspective of 206 participants, with 57.3% representing patient relatives and 51% being male, median age of 32 years (standard deviation: 12.53). Notably, patients reported higher levels of satisfaction, particularly within the interpersonal relationship dimension, while the technical quality domain received comparatively lower satisfaction ratings. Multinomial logistic regression analysis underscored the significance of sociodemographic factors in shaping patient satisfaction, with age (p = 0.008), type of residence (p = 0.001), occupation (p = 0.0019), income status (p = 0.014), time to reach the healthcare facility (p = 0.013), and insurance enrollment status (p = 0.017) all demonstrating significant associations. These findings illuminate the intricate qualities of patient satisfaction within our healthcare context, offering actionable insights for enhancement and guiding the trajectory of future research endeavors.

Conclusions

Overall patient expressed satisfaction with service provided by tertiary care hospital, however continuous improvement remains essential. Conducting large-scale, nationwide studies across hospital tiers is vital. This data-driven approach empowers policymakers to allocate resources effectively, inform decision-making, and enact policies that exceed patient expectations, fostering a healthcare system of unparalleled excellence.
Combinatorial high throughput methodologies: the potentials in heterogeneous catalysts synthesis, screening and discovery—a review
Authors: Emmanuel Jovine Kamuhabwa
Published: February 2024

Background

Catalysis represents a critical field that greatly contributes to human living, technology, economic growth and the environment. Compact catalysts have frequently been applied in manufacturing a range of substances and fuels, thus essentially subsidising income and good living. Catalysts offer significant ecological profits, such as catalytic transformers, fuel cell technology, chemical production and environmental cleaning in automobiles. Still, the use of catalysts is anticipated to raise due to the need to discover ecologically responsive production pathways and affordable products.

Main body of the abstract

Since its discovery, catalysis has played a vital role in a range of fields, from industrial production, sustainable energy strategy and environmental cleaning to the pharmaceutical industry. The discovery and use of catalysts mark a critical aspect in chemistry due to the raising need for greater output plus effectiveness in industry and cleaner production. Despite their importance, the invention of catalysts remained a challenge as it relied on trial-and-error tactics. Customarily, catalysts were developed using various tiresome, time-wasting and usually one-at-a-time techniques characterised and screened for activity and modified until no extra improvements were necessary. However, with the advancement in science and technology, catalyst discovery has been made more accessible and faster through combinatorial techniques. Combinatorial experimentation technologies in chemistry are a fast emerging field that includes the formulation and fast creation of a combination of material libraries and parallel screening for particular chemical or physical characteristics of concern in a general economical and compelling style. These techniques in heterogeneous catalysis are essential for the quick invention of catalysts and for improving the available ones. The rapid and economic invention of catalysts and optimisation of the available ones attract much industrial interest.

Short conclusion

The present review uncovers catalysis development, progress, history and some applications. The latest developments and challenges associated with using high throughput experimentation techniques in synthesising, optimising, discovering and screening catalysts are discussed. A high throughput experimentation approach is potential in catalysis and is promising.
Virome characterization of diarrheic red-crowned crane (G. japonensis)
Authors: Cui Ning , Yang Xiao , Sui Hong , Tan Liugang , Wang Weihua , Su Shuai , Qi Lihong , Huang Qinghua , Hrabchenko Nataliia , Xu Chuantian
Published: February 2024

Background

The red-crowned crane is one of the vulnerable bird species. Although the captive population has markedly increased over the last decade, infectious diseases can lead to the death of young red-crowned cranes while few virological studies have been conducted.

Methods

Using a viral metagenomics approach, we analyzed the virome of tissues of the dead captive red-crowned crane with diarrhea symptoms in Dongying Biosphere Reserve, Shandong Province, China and feces of individual birds breeding at the corresponding captive breeding center, which were pooled separately.

Results

There is much more DNA and RNA viruses in the feces than that of the tissues. RNA virus belonging to the families Picornaviridae, and DNA viruses belonging to the families Parvoviridae, associated with enteric diseases were detected in the tissues and feces. Genomes of the picornavirus, genomovirus, and parvovirus identified in the study were fully characterized, which further suggested that infectious viruses of these families were possibly presented in the diseased red-crowned crane.

Conclusion

RNA virus belonging to the families Picornaviridae, and DNA viruses belonging to the families Genomoviridae and Parvoviridae were possibly the causative agent for diarrhea of red-crowned crane. This study has expanded our understanding of the virome of red-crowned crane and provides a baseline for elucidating the etiology for diarrhea of the birds.
The spin transport properties of Ni(111)/SnSe/Ni(111) lateral tunnel junction
Authors: Zhai Ming-Xing , Chen Ming-Yan , Zheng Xiao-Long , Zhou JiaoJiao
Published: February 2024

Spin-resolved transport properties of the armchair-edged SnSe lateral contact with two magnetic Ni(111) leads are investigated by density functional theory combined with nonequilibrium Green's function method. The spin-polarized currents, magnetoresistances and k-resolved transmission spectrums are simulated in spin parallel and antiparallel configurations. It is found that the heterostructure exhibits a stable spin injection efficiency which can reach up to 80% at low bias range in spin parallel configuration, suggesting the large spin-diffusion length of SnSe. The magnetoresistance can be maintained stably at about 40% at a wide bias range. These results make SnSe material possible to be used in spintronic devices.
Moon-like Facies by Glucocorticoid Is Associated With the Development of Diabetes and Body Image Disturbance
Authors: Tsutsumi Takahiro , Nakagomi Daiki , Kobayashi Kei , Hanai Shunichiro , Kobayashi Yoshiaki , Ito Ryosuke , Ishii Toshihisa , Okuma Hideyuki , Uchinuma Hiroyuki , Ichijo Masashi , Tsuchiya Kyoichiro
Published: February 2024

Context

Moon-like facies (MLF) are a typical side effect of glucocorticoid (GC) therapy; however, its predisposing factors, relationship with GC-induced complications, and effects on body image are not well understood.

Objective

This study aimed to determine the predisposing factors for MLF during GC therapy; its association with GC-induced diabetes, hypertension, and dyslipidemia; and its effects on body image.

Methods

This prospective observational study spanned 24 weeks and targeted patients who received GC therapy at the University of Yamanashi Hospital from June 2020 to August 2022. The MLF was defined based on the following 3 factors: (1) an increase in facial measurement lengths, (2) subjective facial changes by patients’ self-assessment using a visual analog scale; (3) objective and qualitative facial changes assessed by physicians. We examined the predisposing factors for MLF and the association of MLF with GC-induced diabetes, hypertension, dyslipidemia, and body image.

Results

The cumulative incidence rate of MLF at 24 weeks was 37.6%. Predisposing factors for MLF were an initial oral prednisolone dosage of ≥ 30 mg/day [odds ratio (OR) 63.91, 95% confidence interval (CI) 5.82-701.81] and female (OR 6.66, 95% CI 1.35-32.79). MLF showed a significant association with the onset of GC-induced diabetes (OR 6.58, 95% CI 1.25-34.74). MLF was also an independent factor contributing to body image disturbance (β = −18.94, P = .01).

Conclusion

MLF contributes to body image disturbance and is associated with the development of GC-induced diabetes; therefore, it is clinically important as a physical manifestation of GC therapy.
New-Onset Tinnitus After Dorsal Root Ganglion Stimulator Implantation: A Case Report
Authors: Pressler Mark P. , Brenner Brian , Kohan Lynn R. , Mendelson Andrew M.
Published: February 2024

Dorsal column (dcSCS) and dorsal root ganglion stimulation (DRG-S) complications are similar, typically related to placement and device failure. We present the first case of tinnitus after DRG-S implantation. The patient presented with complex regional pain syndrome (CRPS) type 2. After previous failed treatments, she had a lumbosacral DRG-S trial, which provided relief; however, she briefly noted ringing in her ears. After permanent implantation, she reported persistent, intolerable left-sided tinnitus. Tinnitus can be modulated by secondary somatosensory inputs to the cochlear nucleus from the dcSCS. Therefore, lumbosacral DRG-S stimulating distal sensory neurons leading to tinnitus is a feasible complication.
Mu, 49 Marks of Abolition
Authors: Han Sora Y.
Published: February 2024

In March 2020, Sora Y. Han learned her father was dying of cancer just as the COVID-19 pandemic arrived on California's shores. These two events led Han to introspection: “Who have I been writing to?” and “Who have I been writing for?” In her observance of the 49 days of mourning in Buddhist tradition, answers come in the form of mu – no thing, nothingness. Han’s poetic meditations on freedom struggle come alive in the empty spaces between words, letters, and pictograms spanning her many languages—English, Korean, Chinese, jazz, law, and poetry. Transliterating and dystranslating the writings of Fred Moten, Theresa Hak Kyung Cha, Jacques Lacan, Frantz Fanon, and others through the Korean alphabet, Han weaves the DMZ, Betty’s Case, the Thirteenth Amendment, Afro-pessimism, and psychoanalytic desire together into the open field of Bay Area radicalism. Mu is both a loving homage to and a playful subversion of political inheritances and the unsayable beyond law.
Functional consequences of somatic polyploidy in development
Authors: Darmasaputra Gabriella S. , van Rijnberk Lotte M. , Galli Matilde
Published: February 2024

Polyploid cells contain multiple genome copies and arise in many animal tissues as a regulated part of development. However, polyploid cells can also arise due to cell division failure, DNA damage or tissue damage. Although polyploidization is crucial for the integrity and function of many tissues, the cellular and tissue-wide consequences of polyploidy can be very diverse. Nonetheless, many polyploid cell types and tissues share a remarkable similarity in function, providing important information about the possible contribution of polyploidy to cell and tissue function. Here, we review studies on polyploid cells in development, underlining parallel functions between different polyploid cell types, as well as differences between developmentally-programmed and stress-induced polyploidy.
Structure-based engineering of Tor complexes reveals that two types of yeast TORC1 produce distinct phenotypes
Authors: Kamada Yoshiaki , Umeda Chiharu , Mukai Yukio , Ohtsuka Hokuto , Otsubo Yoko , Yamashita Akira , Kosugi Takahiro
Published: February 2024

Certain proteins assemble into diverse complex states, each having a distinct and unique function in the cell. Target of rapamycin (Tor) complex 1 (TORC1) plays a central role in signalling pathways that allow cells to respond to the environment, including nutritional status signalling. TORC1 is widely recognised for its association with various diseases. The budding yeast Saccharomyces cerevisiae has two types of TORC1, Tor1-containing TORC1 and Tor2-containing TORC1, which comprise different constituent proteins but are considered to have the same function. Here, we computationally modelled the relevant complex structures and then, based on the structures, rationally engineered a Tor2 mutant that could form Tor complex 2 (TORC2) but not TORC1, resulting in a redesign of the complex states. Functional analysis of the Tor2 mutant revealed that the two types of TORC1 induce different phenotypes, with changes observed in rapamycin, caffeine and pH dependencies of cell growth, as well as in replicative and chronological lifespan. These findings uncovered by a general approach with huge potential – model structure-based engineering – are expected to provide further insights into various fields such as molecular evolution and lifespan.
Longitudinal Associations between 24-h Movement Behaviors and Cardiometabolic Biomarkers: A Natural Experiment over Retirement
Authors: SUORSA KRISTIN , LESKINEN TUIJA , GUPTA NIDHI , ANDERSEN LARS L. , PASANEN JESSE , HETTIARACHCHI PASAN , JOHANSSON PETER J. , PENTTI JAANA , VAHTERA JUSSI , STENHOLM SARI
Published: February 2024

Introduction

Physical activity, sedentary behavior, and sleep, that is, 24-h movement behaviors, often change in the transition from work to retirement, which may affect cardiometabolic health. This study investigates the longitudinal associations between changes in 24-h movement behaviors and cardiometabolic biomarkers during the retirement transition.

Methods

Retiring public sector workers (n = 212; mean (SD) age, 63.5 (1.1) yr) from the Finnish Retirement and Aging study used a thigh-worn Axivity accelerometer and filled out a diary to obtain data on daily time spent in sedentary behavior (SED), light physical activity (LPA), and moderate-to-vigorous physical activity (MVPA), and sleep before and after retirement (1 yr in-between). Cardiometabolic biomarkers, including LDL-cholesterol, HDL-cholesterol, total/HDL-cholesterol ratio, triglycerides, C-reactive protein, fasting glucose, and insulin, were measured. Associations between changes in 24-h movement behaviors and cardiometabolic biomarkers were analyzed using compositional robust regression and isotemporal substitution analysis.

Results

Increasing LPA in relation to remaining behaviors was associated with an increase in HDL-cholesterol and decrease in total/HDL-cholesterol ratio (P < 0.05 for both). For instance, reallocation of 30 min from sleep/SED to LPA was associated with an increase in HDL-cholesterol by 0.02 mmol·L−1. Moreover, increasing MVPA in relation to remaining behaviors was associated with a decrease in triglycerides (P = 0.02). Reallocation of 30 min from SED/sleep to MVPA was associated with 0.07–0.08 mmol·L−1 decrease in triglycerides. Findings related to LDL-cholesterol, C-reactive protein, fasting glucose, and insulin were less conclusive.

Conclusions

During the transition from work to retirement, increasing physical activity at the expense of passive behaviors was associated with a better lipid profile. Our findings suggest that life transitions like retirement could be utilized more as an optimal time window for promoting physical activity and health.
Wage Garnishment in the United States: New Facts from Administrative Payroll Records
Authors: DeFusco Anthony A. , Enriquez Brandon , Yellen Maggie
Published: February 2024

Wage garnishment allows creditors to deduct money from workers’ paychecks to repay defaulted debts. We document new facts about wage garnishment between 2014 and 2019 using data from a large payroll processor that distributes paychecks to approximately 20 percent of US private-sector workers. By 2019, over 1 in every 100 workers was being garnished for delinquent debt. The average garnished worker experiences garnishment for five months, during which approximately 11 percent of gross earnings is remitted to their creditor(s). The beginning of a garnishment is associated with an increase in job turnover but no intensive margin change in hours worked. (JEL G51, J22, J63)
Bioelectrical impedance vector analysis as an indicator of malnutrition in children under five years with and without pneumonia in Mchinji District, Malawi: An exploratory mixed-methods analysis
Authors: Dunning Hanna , Zadutsa Beatiwel , Kainja Esther , Colbourn Tim , McCollum Eric D. , Makwenda Charles , Wells Jonathan , Grijalva-Eternod Carlos S. , King Carina
Published: February 2024

Background Bioelectrical impedance vector analysis (BIVA) is a non-invasive approach to assessing body composition and cellular health, which may improve the assessment of nutritional status in sick children. We explored the reliability, clinical utility, and acceptability of BIVA, as an indicator of nutritional status for children under five years with and without pneumonia, in Malawi. Methods We conducted a parallel convergent mixed-methods exploratory study in Mchinji District Hospital, Malawi, in 2017. We recruited a convenience sample of children aged 0–59 months with clinical pneumonia, and without an acute illness. Children had duplicate anthropometric and BIVA measurements taken. BIVA measurements of phase angle were taken of the whole body, and trunk and arm segments. Reliability was assessed by comparing the variability in the two measures, and clinical utility by estimating the association between anthropometry and phase angle using linear regression. Focus group discussions with healthcare workers who had not previously used BIVA instrumentation were conducted to explore acceptability. Results A total of 52 children (24 with pneumonia and 28 healthy) were analysed. The reliability of sequential phase angle measurements was lower than anthropometric measurements, but trunk and arm segments performed better. The largest associations with phase angle were a negative relationship with weight-for-age z-score (WAZ) in children with pneumonia in the trunk segment, and a positive association with WAZ in the full body measurement in healthy children. Healthcare workers in focus group discussions expressed trust in BIVA technology and that it would enable more accurate diagnosis of malnutrition; however, they raised concerns about the sustainability and necessary resources to implement BIVA. Conclusions While healthcare workers were positive towards BIVA as a novel technology, implementation challenges should be expected. The differential direction of association between anthropometry and phase angle for children with pneumonia warrants further investigation.
"Thank You" Parts I and II
Authors:   , Hensley Dylan
Published: February 2024

"Thank You" Parts I and II is an experiment that attempts to break new ground in the field of anthropological cinema through the reflexive methodology and experience of myself. My establishment of a new theoretical film approach called meta-anthrochaomediacy and its evolution into radical autoethnographic mediation is explored throughout this thesis. I exercised my theory by producing and documenting a reflexive experience built on fostering emotional bonds and social relationships that provided interactivity and choice within an environment as a process of mediation for anthropological study. Part I features a physical installation I designed that exercised the transmission of memories shared with my familial table. Twelve individuals voluntarily experienced this process across 4 sessions in a single day where they interacted with the table, each other, and the memories of places that the table has lived in. The installation was primarily recorded with a 360 camera and subsequently established as qualitative data, as per my theoretical process, to be edited into a film object. Part II is a 58-minute multi-split-screen film that features my theoretical process in action as it expresses the crafting of emerging-in-real-time short term cultures through layers of reflexivity. I edited this film to test my theory towards exemplifying my film and process as anthropological cinema.
Homoleptic and Heteroleptic Platinum(II) Complexes for Organic Light Emitting Diodes and Humidity Sensors: Synthesis, Characterization, and Applications
Authors:   , Farvid Seyedmajid
Published: February 2024

This dissertation focuses on the design, synthesis, characterization of platinum (II) pyridylazolate complexes and develop high performance organic light emitting diodes (OLEDs) and design and execute high-sensitivity humidity sensors based on the luminescent metal-organic complexes of platinum. A majority of existing platinum compounds do not dissolve in organic solvents, making it difficult to analyze the photophysical characteristics of complexes in solution, a key part of understanding chemical photophysical properties. Furthermore, due to the poor quantum yield, it is inefficient for use in devices such as OLEDs. Chapter 2 reports the synthesis and characterization of a novel heteroleptic platinum(II) pyridylazolate complex with high solubility and quantum yield. The photochemistry of the complex is studied, including efficiency, emission profiles, and lifetimes at different temperatures. Chapter 3 reports the power efficiency (lm/W), current efficiency (cd/A), external quantum efficiency (EQE), luminance and operating voltage (V) of OLED devices made with the heteroleptic platinum(II) pyridylazolate complex. The relation between thickness of hole transport layer and electron transport layer on performance of devices has been studied through building a variety of devices. Chapter 4 includes application of a homoleptic platinum(II) pyridylazolate complex in humidity sensor. In many environments, the relationship between moisture content and emissive wavelength has been investigated. This research reveals that regardless of the humidity level, there is a link between increasing the temperature and decreasing the moisture absorption capacity of the complex.
Analysis of Sensory Integration Techniques on Automatically Maintained Problem Behavior
Authors:   , Pelletier Danielle Renee
Published: February 2024

Sensory integration techniques are a common treatment procedure among occupational therapists. The goal is to "apply" input that competes with input from problem behavior. Although this is a commonly recommended intervention, there is limited empirical evaluation with adults with intellectual disabilities. Therefore, we evaluated the effectiveness of occupational therapist-suggested sensory stimuli on the automatically maintained problem behavior of adults. Specifically, we compared the effects of non-contingent access to sensory stimuli and non-contingent access to highly preferred stimuli on the rate of problem behavior. Results suggested that, relative to highly preferred stimuli, sensory stimuli had either a limited effect on problem behavior, or in some cases, were correlated with increases in problem behavior. This suggests that sensory stimuli may not produce the same automatic stimulation as problem behavior. We will discuss implications for treatment, including methods for better identifying stimuli for use in the treatment of automatically maintained problem behavior.
Increasing Caregiver Reliability on Anecdotal Assessments
Authors:   , Drummond Cody McPhail
Published: February 2024

Functional analyses are the gold standard of confirming maintaining variables of problem behavior. Despite widespread support, many clinical settings instead use anecdotal assessments. These have been shown to have poor reliability when used by non-experts but can be useful for confirming maintaining variables of problem behavior when agreement has reached a certain level. We used behavior skills training to teach new staff member pairs behavior function to increase their reliability on these assessments. We found that although agreement increased slightly, this was not clinically significant. Out of the two pairs of participants one pair of participants was able to identify their client's maintaining variable of problem behavior. Future research should investigate the type of training used for non-experts for example training non-experts to state problem behavior in objective operational terms.
An Analysis of Litigation against North Carolina Educators and School Districts under the North Carolina Tort Claims Act
Authors:   , Harned Jason Douglas
Published: February 2024

This dissertation discussed the impact of the North Carolina Tort Claims Act and the history of governmental immunity that has protected school districts and school employees in North Carolina. The research question addressed was: how have North Carolina state courts interpreted the North Carolina Tort Claims Act in litigation against North Carolina school districts and their employees? The North Carolina Tort Claims Act provided citizens with a vehicle to sue local governmental agencies and their employees, such as school employees. The act also provided immunity for schools, especially for excessive damages in the case of negligence by an employee. The study examined how state courts have responded to different plaintiffs since the passage of the North Carolina Tort Claims Act in 1951. The decisions in the cases analyzed have been mostly favorable to schools, which has strengthened immunity for school employees. There were four legal aspects addressed by the courts after the passage of the North Carolina Tort Claims Act either most frequently or were unique to the case law of North Carolina. Those legal aspects were tests of school districts' governmental immunity; contributory negligence on the part of the plaintiff; the official capacity of school employees in lawsuits; and the scope of the Industrial Commission in North Carolina to hear lawsuits. The case law analysis in this study explained the background of those legal aspects, and when school leaders and teachers were vulnerable to lawsuits due to negligence.
Kinetics and Atmospheric Chemistry Studies of Halogenated Species
Authors:   , Sapkota Ramesh
Published: February 2024

Quantitative information about halogenated hydrocarbons is important for understanding their impact on atmospheric ozone chemistry and climate change, their regulation, and the devising of improved substitutes. The Montreal Protocol aimed to regulate the utilization and manufacturing of hydrochlorofluorocarbon compounds (HCFCs), contributing to ozone layer depletion. The 2016 Kigali Amendment to the Montreal Protocol agreement, Annex C listed 274 HCFCs. Only 16 of them have been measured experimentally. The rest were set to zero by default. These reported global warming potentials (GWPs) play a crucial role in formulating policies for gradually reducing the usage and production of HCFCs to prevent atmospheric impact. Here we are studying 1-chloro-1-fluoro-ethane (CH3CHFCl) as a test of past theory. There are no prior experimental measurements of the reactivity of CH3CHFCl with hydroxyl (OH) radicals, which primarily determines its atmospheric lifetime, nor of its infrared (IR) spectrum. Saturated hydrofluorocarbons (HFCs) are non-ozone depleting substitutes for chlorofluorocarbons deprecated under the 1987 Montreal Protocol on Substances that Deplete the Ozone Layer, but they exhibit high global warming potentials (GWPs) and the Kigali Amendment adopted in 2016 outlines their phase down. Unsaturated HFCs offer more reactive alternatives, whose likely short atmospheric lifetimes would imply small GWPs. Because their GWPs are smaller than those for saturated HFCs by several orders of magnitude, and especially for fully fluorinated examples, several halogenated olefins are under consideration for practical application. We studied HCF2CF2CF=CF2, cis-HCF=HCF, trans HCF=HCF, CF2=CH2 unsaturated HFCs.
"Have You Ever Had a Broken Heart?"
Authors:   , Moore Katherine
Published: February 2024

Have You Ever Had Broken Heart? is a collection of essays that interrogate memory, loss, and grief through the intersection of personal narrative, films, the actress Frances Farmer, and woman saints and mystics from the twelfth through seventeenth centuries who were punished for daring to speak to G-d. The essays engage with autotheory and include a myriad of forms, such as segmented, one sentence, and hybrid works. The films discussed range from the philosophical, such as Ingmar Bergman's Winter Light (1963), to Graeme Clifford's biopic, Frances (1982), to catechize the grief of the persona losing her mother and sister to a hit and run car wreck in June 2022. The persona traverses the realm of the mystics and saints, including Marguerite Porete, Sor Juana Inez De La Cruz, and Joan of Arc, examining their respective quests to experience the unseen and often silent divine, while questioning her longing for G-d, and simultaneously believing G-d cannot exist. Yet, within this confusion, she finds herself immersed in memories which carry the presence of her mother's love.