The Modern Cryobank as Key Support for Clinical Cell and Tissue Transplantation Programmes
Authors:   Tissue Bank University Hospital Hradec Králové, Czech Republic, Měřička Pavel , Jandová Miroslava ,   Tissue Bank University Hospital Hradec Králové, Czech Republic,   Department of Histology and Embryology, Faculty of Medicine in Hradec Králové, Charles University, Czech Republic, Fuller Barry ,   Division of Surgery & Interventional Sciences, UCL Medical School, London, United Kingdom, Gregor Jiří ,   Tissue Bank University Hospital Hradec Králové, Czech Republic, Studená Šárka ,   Tissue Bank University Hospital Hradec Králové, Czech Republic, Lánská Miriam ,   4th Department of Internal Medicine – Haematology, Faculty of Medicine in Hradec Králové, Charles University, Czech Republic,   University Hospital Hradec Králové, Czech Republic, Vokurková Doris ,   University Hospital Hradec Králové, Czech Republic,   Department of Clinical Immunology and Allergology, Faculty of Medicine in Hradec Králové, Charles University, Czech Republic, Jankovičová Karolína ,   University Hospital Hradec Králové, Czech Republic,   Department of Clinical Immunology and Allergology, Faculty of Medicine in Hradec Králové, Charles University, Czech Republic, Fátorová Ilona ,   4th Department of Internal Medicine – Haematology, Faculty of Medicine in Hradec Králové, Charles University, Czech Republic,   University Hospital Hradec Králové, Czech Republic, Brandejs Daniel ,   Tissue Bank University Hospital Hradec Králové, Czech Republic, Guňka Igor ,   University Hospital Hradec Králové, Czech Republic,   Department of Surgery, Faculty of Medicine in Hradec Králové, Charles University, Czech Republic, Benda Aleš ,   Imaging Methods Core Facility at BIOCEV, Faculty of Science, Charles University, Prague, Czech Republic, Sabó Ján ,   Imaging Methods Core Facility at BIOCEV, Faculty of Science, Charles University, Prague, Czech Republic, Janoušek Libor ,   Department of Transplantation Surgery, Institute of Clinical and Experimental Medicine, Prague, Czech Republic,   1st Faculty of Medicine, Charles University, Prague, Czech Republic, Špaček Miroslav ,   1st Faculty of Medicine, Charles University, Prague, Czech Republic,   General University Hospital, Prague, Czech Republic
Published: November 2024

The authors review the essential role of modern cryobanks in the development of cryotechnology before the start of the clinical cell and tissue transplantation programme and in the routine support of these programmes within the legislative framework settled by the European Union directives. Two clinical programmes are presented as examples: the autologous and allogeneic haematopoietic progenitor cell (HPC) transplantation programme and the Czech national cryopreserved allogeneic vascular tissue (VT) transplantation programme supported by the cryobank of the University Hospital Hradec Králové, which is a part of the European Union Tissue Establishment registered under the codes CZ000425, CZ000426 and CZ000427. An overview of necessary approvals to be obtained before the start of clinical programmes is presented, the high quality of cryopreservation technology and high level of cryobank staff safety is demonstrated, and the crucial role of the cryobank in clinical HPC and VT transplantation programmes is highlighted.