bluuebunny/crossref_metadata_2025 huggingface dataset:
Export unit value across markets: dampened by export subsidies
Authors: Nakhoda Aadil
Published: September 2023

The export unit value is influenced by the characteristics of the export market destination. However, this influence is dampened when export subsidies are provided by the government on specific products to incentivize the exporters. We use firm-level data on Pakistani exporters merged with product-level data on the provision of export subsidies in this study. We find that the provision of export subsidies on the products exported dampens this relationship as some of the export market characteristics that otherwise influence export unit value become insignificant. We split the sample of firms according to the product classification of the products exported, such as differentiated industrial products and homogenous non-industrial products, and the size of total export sales to determine whether the provision of export subsidies dampens the impact of export market characteristics on export unit value across the different product classifications as well as across larger and smaller exporters. We believe that the results have implications for policymakers providing incentives to the exporters.
JEL code: F12; F13; L25; L52
Antioxidant defenses determine the maturation and physiological quality of in vitro Euterpe edulis Martius seeds
Authors: de Mello Tamyris , Neto Antonio Rodrigues da Cunha , Taliuli Yanara dos Santos , de Araujo Caroline Palacio , Hegedus Clovis Eduardo Nunes , Anjos Breno Benvindo dos , Schmildt Edilson Romais , Ferreira Adésio , Santos Heloisa Oliveira dos , Lopes José Carlos , Otoni Wagner Campos , Alexandre Rodrigo Sobreira
Published: September 2023

The palm Euterpe edulis Martius is native to the Atlantic Forest. The nutritional composition and antioxidant potential of its fruits are superior to those of Euterpe oleracea and Euterpe precatoria. The present study aimed to analyze the antioxidant defenses associated with in vitro germination of E. edulis and the quality of its seedlings. Seeds were harvested at 29 maturation stages (94–290 days after anthesis, DAA), and characterized in terms of budding, vigor, seedling formation, antioxidant defenses (superoxide dismutase, catalase, ascorbate peroxidase, and anthocyanins), hydrogen peroxide, lipid peroxidation, and hormonal composition. Fruit dry mass and volume did not differ from 241 DAA; whereas seed dry mass peaked 255 DAA, decreasing after this period. Seed moisture decreased throughout maturation. Seedling-related variables achieved the highest average values 227 DAA. The seeds showed maximum germination, vigor, percentage of normal seedlings, concentration of ZEA and ABA at 164 DAA. From 269 DAA, a decrease in dry mass suggested increased reserve consumption (respiration), inhibition of nutrient translocation to seeds, and reduction in water content (desiccation). The resulting greater sensitivity to environmental variations coincided with increased oxidative stress, but was counteracted by antioxidant defenses.
Piecewise modification of cycloidal gear in RV reducer: application of spline interpolation theory and comparison with a combination modification optimization method
Authors: Gao Song , Li Yiwan , Zhang Yueming , Ji Shuting , Li Wentai
Published: September 2023

Rotate vector (RV) reducers are typical deceleration elements with the outstanding characteristics of small size, compact structure, strong load-bearing capacity, and low transmission error, which are widely applied in fields of industrial robots, aerospace, and measurement instruments. The cycloidal gear, as the core component of the second-stage drive in RV reducer, its tooth profile directly determines the general performance of RV reducer such as meshing precision, load-bearing capacity, and riding stability. Therefore, it is necessary to explore and propose feasible methods and parameters for modification of cycloidal tooth profile. In this paper, taking the CRV-20E reducer as an object, firstly, a theoretical model for maximum contact stress and load distribution coefficient on meshing surfaces was established. Based on genetic algorithm, a multi-objective optimization for cycloidal profile was proposed with maximum contact stress and load distribution coefficient as objective functions, and the optimal combination of modification parameters was obtained. Secondly, with the idea of piecewise and the spline interpolation method, the cycloidal profile was separated into three segments of dedendum, working, and addendum. It ensured the conjugated meshing between cycloidal and pin tooth profile during working segment, besides, it remained various clearances in dedendum and addendum according to specific requirements. Finally, finite element simulation analysis was conducted on cycloid-pin gear drive mechanism, which containing for both two types of modified tooth profile, respectively. The simulation results verified the correctness of theoretical model and the feasibility of the proposed two modification methods.
Fabrication of TPGS decorated Etravirine loaded lipid nanocarriers as a neoteric oral bioavailability enhancer for lymphatic targeting
Authors: Muheem Abdul , Wasim Mohd. , Aldosari Eman , Baboota Sanjula , Ali Javed
Published: September 2023

Etravirine (ERVN) is a potential NNRTI (non-nucleoside reverse transcriptase inhibitor) in treating HIV infection. It possesses extremely low oral bioavailability. The present research aims to optimize the formulation and characterization of TPGS-enriched ERVN-loaded lipid-based nanocarriers (LNCs) for HIV-infected patients. The formulation, ERVN-TPGS-LNCs, was optimized by CCRD using a modified-solvent evaporation process. Various characterization parameters of LNCs were evaluated, including globule size of 121.56 ± 2.174 nm, PDI of 0.172 ± 0.042, the zeta potential of -7.32 ± 0.021 mV, %EE of 94.42 ± 8.65% of ETR and %DL was 8.94 ± 0.759% of ERVN and spherical shape was revealed by TEM. PXRD was also performed to identify the crystallinity of the sample. In-vitro drug release showed % a cumulative drug release of 79.77 ± 8.35% at pH 1.2 and 83.23 ± 9.11% at pH 6.8, respectively, at the end of 48h compared to pure drug suspension (ERVN-S). Further, the intestinal permeation study and confocal microscope showed approximately ~3-fold and ~2-fold increased permeation in ERVN-TPGS-LNCs and ERVN-LNCs across the gut sac compared to ERVN-S. Hemolysis compatibility and lipolysis studies were performed to predict the in-vivo fate of the formulation. The pharmacokinetic study revealed a 3.13-fold increment in the relative bioavailability, which agrees with the ex-vivo studies, and lymphatic uptake was validated by using cycloheximide (CYHD) along with designed formulation, which leads to lowering AUC of ERVN-TPGS-LNCs. Thus, this study ensures that ERVN-TPGS-LNCs take lymphatic uptake to minimize the first-pass metabolism followed by improved oral bioavailability of EVN. Thus, the enhanced bioavailability of ERVN can reduce the high dose of ERVN to minimize the adverse effects related to dose-related burden.
Effect of feeding total mixed ration with ad libitum or restricted pelleted starter on growth performance, rumination behaviour, blood metabolites and rumen fermentation of Holstein calves
Authors: Spina Anna Antonella , Lopreiato Vincenzo , Britti Domenico , Minuti Andrea , Trevisi Erminio , Morittu Valeria Maria
Published: September 2023

The objective of this study was to evaluate the effects of diet with ad libitum TMR and restricted starter on animal performance, rumination time, blood metabolites and rumen fermentation of Holstein calves during the pre- and post-weaning periods. Thirty female Holstein calves were randomly assigned at birth (38.5 ± 1.96 kg) to receive 3 treatments. Calves, from 21 days of age, were fed 1 of 3 treatments as follows: Control diet (CTR) with TMR and starter ad libitum; Treatment 1 diet (TRT1) with TMR and starter ad libitum; Treatment 2 diet (TRT2) with ad libitum TMR and restricted amount of calf starter (50% of the intake recorder in the control group day by day. The results showed that the reduced amount of starter did not compromise the growth of calves nor did it compromise the ruminal and metabolic parameters of the animals. The inclusion of ad libitum TMR indeed, improved the rumination time especially after weaning. Overall, the results indicated that the calf starter can be partially replaced with a TMR in weaning calves, reducing the feeding costs of weaning dairy calves.
Rendering Lineament Induced Stream alignment in Upper Krishna Basin, India: A Geospatial Approach
Authors: Pardeshi Suchitra S. , Pardeshi Sudhakar , Autade Sumant Eknath , Raut Tushar Prakash
Published: September 2023

Lineaments play an important role in drainage development, stream alignment and groundwater recharge. These are traced as surface or subsurface features. A linear feature that is associated with dislocation and deformation is known as lineament. The present study aimed to identify the influence of lineaments extracted from satellite images in the Upper Krishna River basin in India. Remote sensing datasets are considered the best option when using image enhancement techniques for extracting lineaments. Lineament studies are useful for groundwater and mineral exploration and also in the field of engineering geology. The availability of high-resolution satellite data and image processing techniques have rendered it further convenient to map lineaments. In the present study, lineaments were extracted from Sentinel–2 images with a resolution of 10 m, using various image processing techniques. A total of 1314 lineaments were extracted from the study area with a total length of 3983.44 km. The analysis of the extracted lineaments revealed that the lineament density was higher in the upper reaches of the basin, where the undulating hilly region is located in the Western Ghats. This finding implied that these regions have a high structural deformation and a higher groundwater infiltration potential. Moreover, approximately 15% of the total stream length was observed to be influenced by the lineaments. The maximum influence of lineaments was observed in the source region. The lineament extraction results of the present study would assist in understanding the geomorphology of this region and the structural control on the streams and groundwater potential zones, particularly as a contribution to water resource management in this region.
Real-World Outcomes Of Lu-177 PSMA In Patients With Metastatic Castration-Resistant Prostate Cancer: A Retrospective Single-Center Experience
Authors: Karci Ebru , Aydin Sabin Goktas , Bilici Ahmet , Atasever Tamer , Cakir Tansel , Olmez Omer Fatih , Acikgoz Ozgur , Kutlu Yasin , Yildiz Ozcan
Published: September 2023

Aim: This studyaimed to assess the influence of laboratory and clinicopathological features on survival and treatment response as well as the importance of uptake changes in PSMA-PET-CT after Lutetium-177-PSMA treatment in metastatic castration-resistant prostate cancer(mCRPC).
Material-Method: Totally,38 men with mCRPC who received Lu-177 )at a dose of 4.0 to 6.8 GBq with a mean of 5.5 GBq once every six or nine weeks for 1 to 6 cycles (median 3) were included in this study. PSMA PET with computed tomography was performed for response evaluation. Pre and post-treatment laboratory and imaging findings were obtained from patients’ charts and analyzed retrospectively.
Results: At a median follow-up of 12.2 months, the median PFS and OS were 5.8 and 12.3 months, respectively. The objective response rate was 36.8%. Any grade and grade3/4 toxicity rates were as follows:86.8%(n=33) and57.9%(n=22).The presence of visceral metastasis, ALP, PSA, and SUVmax values were significant prognostic factors for PFS.The SUVmax value of <4 after treatment was an independent significant factor for PFS in multivariate analysis (p=0.002; HR:6.6,95%CI 2.03-22.00). The significant prognostic factors for OS were previous treatment lines, presence of visceral metastasis, ECOG PS PSA and ALP values, and median SUV max value after treatment.The multivariate analysis for OS indicated that ECOG PS (p=0.01, HR:16.7, 95%CI 1.58-176.32), pre LU-177-PSMA ALP values (p=0.05;HR:0.96,95% CI 0.93-1.00),post Lu-177 PSA values(p=0.02;HR:1.01,95%CI1.00-1.03)and SUV max value p=(0.005;HR:6.6,95%CI1.74-25.1)were independent prognostic factors.
Conclusion: ECOG PS, baseline ALP values, PSA response, and SUV response of the target lesion were the independent prognostic factors for OS. Thus Lu-177-PSMA is an effective option with a good safety profile in second and later lines of treatment for patients with mCRPC.
Core-shell structured SiO2@C-Sn/SnO2 nanosphere as an anode material for high-performance lithium-ion batteries
Authors: Zhai Jianguang , HUANG YUCHEN , wei Yongji
Published: September 2023

In this paper, a SiO2@C-Sn/SnO2 nanospheres with core-shell structure were synthesized by the hard template method using resorcinol-formaldehyde resin as a carbon source and the hydrolysis of SnCl4-5H2O. Tin material as lithium battery anode has the advantages of high specific capacity and low voltage plateau. This innovative core-shell structure exhibits excellent electrochemical lithium storage performance, making it an excellent candidate for lithium-ion batteries. After 100 cycles, the material demonstrated a notable reversible capacity of 591.8 mAh g− 1 at a current density of 100 mA g− 1. In addition, the stability of the core-shell structure provides excellent capacity retention for the battery.
Numerical modelling of the upwelling and associated hydrodynamics at various scales along the coral reefs at Sodwana Bay, South Africa
Authors: Wells Calvin , Pringle Justin , Stretch Derek
Published: September 2023

Coral reefs are strongly influenced by hydrodynamics and physical processes on various length and time scales, and understanding coral reef systems are crucial for the maintenance and survival of the reefs. Coral reefs around the world are under increasing threat to global climate change, and coral bleaching is a major concern for the health and survival of these reefs. Certain coral reefs are situated in high latitude areas where the complex ocean flow patterns interact with topographical features, providing certain refuges to rising ocean temperatures. A prominent example is the Sodwana Bay coral reef system which has shown resilience to coral bleaching. This resilience has been attributed to cold water temperature anomalies that cause short-term temperature fluctuations on the reefs. This study explores hydrodynamics at various scales around the Sodwana Bay coral reefs and associated short-term temperature anomalies. A flexible mesh hydrodynamic model of the southwest region of the Indian Ocean was developed to investigate short-term temperature anomalies on the Sodwana coral reef system located along the northeastern coast of South Africa. The model successfully replicates the observed temperature anomalies over a chosen representative year. The modelled on-reef temperatures during the temperature anomaly events were also compared to temperatures near Sodwana from the reanalysis NEMO global ocean model. The higher model resolution around Sodwana results in less numerical effects and smoothing of the temperature fields in the nearshore region when compared to the reanalysed NEMO model. A representative anomaly in Febru-ary 2004 was also investigated using the nested model to delineate the impact of local hydrodynamics in and around submarine canyons on the representative temperature anomaly.
Lateral root enriched Massilia associated with plant flowering in maize
Authors: Wang Danning , He Xiaoming , Baer Marcel , Lami Klea , Yu Baogang , Tassinari Alberto , Salvi Silvio , Schaaf Gabriel , Hochholdinger Frank , Yu Peng
Published: September 2023

Background
Beneficial interactions between plants and soil microorganisms are critical for crop fitness and resilience. However, it remains obscure how microorganisms are assembled across different root compartments and to what extent such recruited microbiomes determine crop performance. Here, we surveyed the root transcriptome and the root and rhizosphere microbiome via RNA sequencing and full-length (V1−V9) 16S rRNA gene sequencing from genetically distinct monogenic root mutants of maize (Zea mays L.) under different nutrient-limiting conditions.
Results
Integrated transcriptomic and microbial analyses demonstrated that mutations affecting lateral root development had the largest effect on host gene expression and microbiome assembly, as compared to mutations affecting other root types. Cooccurrence and trans-kingdom network interactions analysis demonstrated that the keystone bacterial taxon Massilia (Oxalobacteraceae) is associated with root functional genes involved in flowering time and overall plant biomass. We further observed that the developmental stage drives the differentiation of the rhizosphere microbial assembly, especially the interactions of the keystone bacteria Massilia with functional genes in reproduction. Taking advantage of microbial inoculation experiments using a maize early flowering mutant, we confirmed that Massilia-driven maize growth promotion indeed depends on flowering time.
Conclusion
We conclude that specific microbiota supporting lateral root formation could enhance crop performance by mediating functional gene expression underlying plant flowering time in maize.
Preliminary study: Cognitive behavioural therapy for insomnia in adolescents suffering from anorexia nervosa
Authors: CREVITS Léna , BAT-PITAULT Flora , SILVA Catarina GONZALEZ DA
Published: September 2023

Purpose: Insomnia and anorexia nervosa (AN) are frequently comorbid, which negatively impacts the evolution and the prognosis of AN. Thus, the management of sleep disorders appears to be essential. The aim of this retrospective study is to asses, for the first time, the efficacy of the cognitive and behavioural therapy for insomnia (CBT-I) on sleep disturbances in adolescents with AN. To do so, we investigated the impact of the CBT-I on BMI, anorexia nervosa symptoms, anxiety and depressive symptoms, emotionality and quality of life. These features were compared between two groups of patients with AN, one following the CBT-I, and the other receiving the regular treatment at the psychiatric unit.
Methods: Data were collected between January and May 2022. 42 adolescents in treatment at the Eating Disorders care specialised unit at Salvator Hospital in Marseille were included. They were randomly assigned to the CBT-I or the control group. Diverse clinical elements were assessed using sleep diaries and validated subjective measurement scales.
Results: Present findings show a significant improvement in certain sleep parameters: sleep latency, total wake time, and sleep efficacy ; as well as physical well-being, favouring the group undergoing the CBT-I.
Conclusion: This preliminary study on sleep disturbances in adolescents with AN provides support to the efficacy of CBT-I, with significant improvements in several sleep parameters, as well as in physical well-being. These promising initial results, underline the relevance on this topic and its potential benefits for a more suitable treatment for adolescents suffering from AN.
Level of evidence: Level V, restrospective study
Neuroinflammation in a Mouse Model of Alzheimer’s Disease versus Auditory Dysfunction: Machine Learning Interpretation and Analysis
Authors: Na Daxiang , Yang Yidan , Xie Li , Piekna-Przybylska Dorota , Bunn Dominic , Shamambo Maleelo , White Patricia
Published: September 2023

Background
Auditory dysfunction, including central auditory hyperactivity, hearing loss and hearing in noise deficits, has been reported in 5xFAD Alzheimer’s disease (AD) mice, suggesting a causal relationship between amyloidosis and auditory dysfunction. Central auditory hyperactivity correlated in time with small amounts of plaque deposition in the inferior colliculus and medial geniculate body, which are the auditory midbrain and thalamus, respectively. Neuroinflammation has been associated with excitation to inhibition imbalance in the central nervous system, and therefore has been proposed as a link between central auditory hyperactivity and AD in our previous report. However, neuroinflammation in the auditory pathway has not been investigated in mouse amyloidosis models.
Methods
Machine learning was used to classify the previously obtained auditory brainstem responses (ABRs) from 5xFAD mice and their wild type (WT) littermates. Neuroinflammation was assessed in six auditory-related regions of the cortex, thalamus, and brainstem. Cochlear pathology was assessed in cryosection and whole mount. Behavioral changes were assessed with fear conditioning, open field testing and novel objection recognition.
Results
Reliable machine learning classification of 5xFAD and WT littermate ABRs were achieved for 6M and 12M, but not 3M. The top features for accurate classification at 6 months of age were characteristics of Waves IV and V. Microglial and astrocytic activation were pronounced in 5xFAD inferior colliculus and medial geniculate body at 6 months, two neural centers that are thought to contribute to these waves. Lower regions of the brainstem were unaffected, and cortical auditory centers also displayed inflammation beginning at 6 months. No losses were seen in numbers of spiral ganglion neurons (SGNs), auditory synapses, or efferent synapses in the cochlea. 5xFAD mice had reduced responses to tones in fear conditioning compared to WT littermates beginning at 6 months.
Conclusions
Serial use of ABR in early AD patients represents a promising approach for early and inexpensive detection of neuroinflammation in higher auditory brainstem processing centers. As changes in auditory processing are strongly linked to AD progression, central auditory hyperactivity may serve as a biomarker for AD progression and/or stratify AD patients into distinct populations.
Child and Adolescent Psychiatry and Mental Health Transitioning to Adult Mental Health Services for young people with ADHD: an Italian-based Survey on practices for Pediatric and Adult Services
Authors: Roberti Elisa , Scarpellini Francesca , Campi Rita , Giardino Michele , Clavenna Antonio , Bonati Maurizio
Published: September 2023

Background. Supporting young ADHD patients in transition to adult services is essential. Yet, the low percentages of successful referrals and the issues reported by patients and clinicians stress the need for further attention to transitioning practices. The present study assessed the transitioning process of Attention-Deficit/Hyperactivity Disorder (ADHD) patients in Child and Adolescent Mental Health Services (CAMHS) and Adult Mental Health Services (AMHS) in the Italian territory. We asked child and adult psychiatrists to report the current state of services and their observations on limitations and possible future matters that must be addressed. Method. Seventy-seven centers (42 CAMHS, 35 AMHS) filled in a web-based survey in which they reported the number of ADHD patients, how many transitioning patients they had within the past year, and how they structured transition. Results. A fragmented picture emerged from the survey. Lack of resources, training, and communication between services hinder the transition process, and many adult patients remain under CAMHS' care. While some services have a protocol, there is no structured guidance that can help improve integration and continuity of treatment. Conclusion. The observed situation reflects a need for improvement and standard guidelines to enable a successful transition process, considering clinicians' and patients' necessities.
Is Strategy Instruction Still Needed? A Comprehensive Analysis of Learner Strategies in High School EFL Context
Authors: Çelik Ferdi , Yeşilel Deren Başak Akman
Published: September 2023

This quantitative paper thoroughly explores strategy utilization among English as a Foreign Language (EFL) students in a Turkish high school, examining potential differences based on proficiency levels and gender. A sample of 78 students (39 females, 39 males) participated, and data collection involved a comprehensive strategy inventory. The findings revealed that high-proficiency learners exhibited a wider range of strategies, with compensation and metacognitive strategies being the most prominent. Medium proficiency learners demonstrated moderate strategy use, emphasizing balance and metacognitive strategies. Conversely, low-proficiency learners engaged in strategies to a lesser extent, leaning towards social strategies. Gender, however, did not significantly influence overall strategy use across proficiency levels. Practical implications are discussed, suggesting EFL teachers incorporate metacognitive and cognitive strategy instruction to optimize students’ learning. Coursebook authors are recommended to integrate strategy use, particularly tailored for lower proficiency learners, while learners are encouraged to adopt strategies consciously to enhance their language learning experience. This research contributes valuable insights into language learning strategies, facilitating improved educational practices for EFL students.
Patterns of Corruption During COVID-19 in Bangladesh
Authors: Sakib Nurul Huda , Mollik Md Meshkat
Published: September 2023

Corruption during COVID-19 has reached global proportions. During COVID-19, corruption was rampant in numerous nations around the world, especially in the health sector. Bangladesh is not an exception. This paper aims to analyse the various forms and faces of corruption with their frequency levels using AntConc and corpus linguistics analysis, as well as convert all of the data into visual graphics using SPSS and R-Programming. Using related keywords, over 1200 corruption news stories were gathered from a number of national daily newspapers and national television news sources. The analysis begins with COVID-19 by reviewing categorical forms of political corruption and bureaucratic corruption, demonstrating the most essential examples of typologies, establishing corruption levels, and indicating where corruption originated. All analyses in this study, including occurrences, keywords, n-grammes, and concordances, indicate that corruption during COVID-19 was substantial and had a substantial effect on the health sector. Therefore, we begin by identifying corruption month-by-month in both 2020 and 2021. Moreover, we discovered political, bureaucratic, and both types of corruption concurrently during the time period in which all stakeholders benefited from the corrupt transition. Along with bribery and extortion, we found that nepotism, embezzlement, and lobbying were prevalent during the time period. We also discovered statistically significant instances of terms such as 'health,' 'government,' 'corruption, “money/tk,' and 'JKG', which indicate institutional corruption. In addition, while analysing the evidence of corruption frequency in Bangladesh, we discovered that it was symmetrical and unimodal. The average frequency of corruption during COVID-19 in Bangladesh was approximately 70, with a standard deviation of 20. In conclusion, our qualitative analysis identifies three major problems: corruption in the "health" sector, the greed of involved stakeholders, and the incompetence of government officials, which has made governance in Bangladesh more challenging.
A self-amplifying loop of TP53INP1 and P53 drives oxidative stress-induced apoptosis of bone marrow mesenchymal stem cells
Authors: Zhang Fei , li fanchao , Wang Tao , Peng Wuxun , Xie Zhihong , Luo Hong , Dong Wentao , Zhang Jian , Ren Chao
Published: September 2023

Bone marrow mesenchymal stem cell (BMSC) transplantation is a promising regenerative therapy, but the survival rate of BMSCs after transplantation is low. Oxidative stress is one of the main reasons for the high apoptosis rate of BMSCs after transplantation, so there is an urgent need to explore the mechanism of oxidative stress-induced apoptosis of BMSCs. Our previous transcriptome sequencing results suggested that the expression of P53-induced nuclear protein 1 (TP53INP1) and the tumor suppressor P53 (P53) was significantly upregulated during the process of oxidative stress-induced apoptosis of BMSCs. The present study further revealed the role and mechanism of TP53INP1 and P53 in oxidative stress-induced apoptosis in BMSCs. Overexpression of TP53INP1 induced apoptosis of BMSCs, knockdown of TP53INP1 alleviated oxidative stress apoptosis of BMSCs. Under oxidative stress conditions, P53 is regulated by TP53INP1, while P53 can positively regulate the expression of TP53INP1, so the two form a positive feedback loop. To clarify the mechanism of feedback loop formation, We found that TP53INP1 inhibited the ubiquitination and degradation of P53 by increasing the phosphorylation level of P53, leading to the accumulation of P53 protein. P53 can act on the promoter of the TP53INP1 gene and increase the expression of TP53INP1 through transcriptional activation.This is the first report on a positive feedback loop formed by TP53INP1 and P53 under oxidative stress. The present study clarified the formation mechanism of the positive feedback loop. The TP53INP1–P53 positive feedback loop may serve as a potential target for inhibiting oxidative stress-induced apoptosis in BMSCs.
Comparision Between CO2 Laser Tonsillectomy and Cold Dissection Tonsillectomy: Single Blind Randomised Controlled Study
Authors: Sanjel Anup
Published: September 2023

Background: History of tonsillectomy is very long back and the first procedure was carried out by Celsus in 40 AD. There are many methods of tonsillectomy like guillotine, cold steel, snare with suture, electro cautery, hot-knife, bipolar, LASER etc.
Aims and Objectives: The aim of this study was to compare intensity of post-operative pain between CO2 laser tonsillectomy and cold dissection tonsillectomy.
Methods: Single blind Randomized controlled study was conducted at BPKIHS, Department of Otorhinolaryngology and Head & Neck surgery
Results: Study revealed less postoperative pain in LASER side than in cold steel dissection side. Average pain score scaled with VAS was 7.40±1.297 in cold steel dissection whereas 5.15±1.292 for CO2 LASER tonsillectomy. The pain score at 24hrs shows that more than half of the patient with cold steel dissection side have developed severe degree of pain. Whereas most of the patient have only moderate level of pain in the CO2 laser tonsillectomy side. Pain score was 3.65±1.231 for CO2 LASER tonsillectomy and 6.45±1.319 in a cold dissection side at 48hrs. The mean pain score of LASER tonsillectomy at 72 hours was 2.88±0.82 whereas the mean pain score of cold steel dissection method was 4.63±1.079.
Conclusion: In the present study, The CO2 laser is associated with less post-operative pain than cold steel dissection method however duration of surgery is more on the LASER side.
Association of the TNFRSF1B rs1061622 variant with nonresponse to infliximab in ulcerative colitis
Authors: Tessier Laurence , Gagnon Ann-Lorie , St-Amour Sophie , Côté Mathilde , Allard Catherine , Durand Mathieu , Bergeron Danny , Lavoie Alexandre , Michaud-Herbst Alban , Tremblay Karine
Published: September 2023

For severe forms of ulcerative colitis (UC), a chronic inflammatory bowel disease (IBD), biological therapies, including tumor necrosis factor inhibitors (anti-TNF), are often used. However, these drugs have a high variability in treatment response. Multiple factors, such as genetic variants, can affect this variability. The goal of the study was to verify if selected candidate variants could affect response to anti-TNF in UC treatment. This association study included 76 participants suffering from UC and past or current users of anti-TNF. Clinical data for phenotyping was collected through a single visit with the participant and a medical chart review. Blood or saliva samples were collected to extract DNA and to genotype eight selected candidate variants in genes TNF, TNFAIP3, TNFRSF1A and TNFRSF1B. For anti-TNF users, 30% of individuals were non-responders, 70% suffered from AE and none of the studied variants was associated with the response’s phenotype. However, for infliximab users only (n = 44), the TNFRSF1B-rs1061622 variant was associated with nonresponse to infliximab for the first time in a cohort of UC patients (p-value = 0.028). Next steps are to replicate this association in independent cohorts and to perform functional studies to gain more evidence on the variant.
Attitudes Toward and Preferences of Florida Consumers and Growers Regarding a Proposed Scientifically Based University Certification Process for Wildlife-friendly Plants
Authors: Nickerson Caroline , Krebs Christine , Warner Laura A. , Baker Lauri , Daniels Jaret , Dale Adam
Published: September 2023

This article shares survey results provided by both consumers and growers regarding the University of Florida Biodiversity Certified Plants for the Rapidly Expanding Urban Landscape Market project conducted at the University of Florida (UF). The overall goal of this project was to develop and test a scientifically based, UF-trademarked process for the certification of high-quality, commercially available, wildlife-friendly plants for the green industry. The objectives of two surveys that targeted consumers and growers, respectively, were to assess consumer and grower attitudes, knowledge, and behaviors pertaining to wildlife-friendly plants and a proposed certification. The consumer survey results (n = 868) indicated that respondents (consumers) strongly agreed with purchasing wildlife-friendly plants, and that respondents would benefit from the proposed certification. The certification could help consumers gain a better understanding of which plants are wildlife-friendly at the point of purchase. Nearly half of consumers reported an inability to identify wildlife-friendly plants in the store, which hinders them from purchasing. The grower survey results (n = 75) indicated that respondents were willing to offer biodiversity-certified plants. More growers rated themselves as innovators (the most innovative category) in terms of adopting innovations than any other diffusion of innovations category (early adopter, early majority, later majority, hesitant, or none of these), although the perceived cost of obtaining the certification was seen as a potential barrier toward grower adoption of the certification. These findings indicate that the proposed certification would be successful with appropriate and tailored marketing materials for both growers and consumers.
Quantum oscillations in an impurity-band Anderson insulator
Authors: Cooper Nigel R. , Kelsall Jack
Published: September 2023

We show that for a system of localized electrons in an impurity band, which form an Anderson insulating state at zero temperature, there can appear quantum oscillations of the magnetization, i.e. the Anderson insulator can exhibit the de Haas-van Alphen effect. This is possible when the electronic band from which the localized states are formed has an extremum that traces out a nonzero area in reciprocal space. Our work extends existing theories for clean band insulators of this form to the situation where they host an impurity band. We show that the energies of these impurity levels oscillate with magnetic field, and compute the conditions under which these oscillations can dominate the de Haas-van Alphen effect. We discuss our results in connection with experimental measurements of quantum oscillations in Kondo insulators, and propose other experimental systems where the impurity band contribution can be dominant.
Evaluating one-loop string amplitudes
Authors: Eberhardt Lorenz , Mizera Sebastian
Published: September 2023

We evaluate one-loop open-string amplitudes at finite \alpha'α′ for the first time. Our method involves a deformation of the integration contour over the modular parameter \tauτ to a fractal contour introduced by Rademacher in the context of analytic number theory. This procedure leads to explicit and practical formulas for the one-loop four-point amplitudes in type-I superstring theory, amenable to numerical evaluation. We plot the amplitudes as a function of the Mandelstam invariants ss and tt and directly verify long-standing conjectures about their behaviour at high energies.
Post-Pandemic Home-Based Work in Cities of the South Lessons from Enugu, Nigeria
Authors: Ezeadichie Nkeiru Hope
Published: September 2023

Income-generating activities in residential zones known as Home-Based Enterprises (HBEs) are becoming more prevalent as a result of the COVID-19 pandemic. The informal sector, including HBEs, started expanding in cities of the Global South in the 1980s during the Structural Adjustment
Programme and has engendered debates among practitioners and researchers. The International Labour Organization Home Work Convention, C177 of 1996, and the inclusion of home work in national accounting because of its contribution to Gross Domestic Product have emboldened researchers to argue
for a supportive policy framework. Yet, this phenomenon is still opposed by contemporary planning practices in many Global South cities. The lockdown during the pandemic which aff ected every aspect of life across the world revealed the indispensability of home-based enterprises: 'work' that
had to be kept functional was done from home. Will the implications of lockdown and post-pandemic home-based work lead to a paradigm shift in the Global South from the rigid colonial planning standards to eff ective and dynamic planning standards that are based on contemporary urban realities?
The aim of this study is, therefore, to examine the implications of post-pandemic home-based enterprise for the built environment in Global South cities using Enugu, Nigeria as a case study. The mixed research design was adopted for the study, while data were collected through questionnaires
and in-depth interviews. Stratified random sampling was employed to select three (one low, medium, and high density) from the existing thirty-three formal neighbourhoods in the study city – Enugu. Systematic sampling was adopted to select the sample size among the residents and the professionals
were selected purposively. The result of the principal component analysis reveals that there are six major impacts of HBEs on the built environment in Enugu, namely: entrepreneurship skills; pressure on infrastructure; improved living standards; discrimination; in fluence on work–life
balance; and limited growth potential. Major lessons from the study include:adaptation of innovative urban planning; enhancement of local economic development; gender and policy issues.This research is signi ficant as it will contribute to the literature on COVID-19 in the Global South and
connect the post-COVID-19 recovery experience from a core Global South city to possible, effective actions that can mitigate future challenges in comparable cities and contexts.
Comparing the resilience of Sharia and conventional banking to the financial crisis in the Association of Southeast Asian Nations
Authors: Suripto  , Sugiono Arif , Dasuki Havid
Published: September 2023

This study aims to analyze the comparison of the resilience of Islamic and conventional banking in the Association of Southeast Asian Nations (ASEAN) during the COVID-19 pandemic. Comparison of banking resilience was proxied by the Capital Adequacy Ratio (CAR) and Loan-to-Deposit Ratio (LDR) factors, Return on Assets (ROA) and Non-Performing Loans (NPL) with the Multiple Discriminant Analysis test. In this case, the emphasis is placed on the patterns by which Islamic and conventional banking in ASEAN weathered the recent financial crisis during the COVID-19 pandemic. The explanatory and quantitative analysis also used a purposive sample strategy and SPSS to obtain and analyze data from 120-unit analyses of Islamic and conventional banks, respectively. From 2020 to 2021, traditional banks in the ASEAN region, especially in Indonesia, Malaysia, and Brunei Darussalam, were emphasized. Moreover, some data were prioritized regarding the Comparison of Resilience of Sharia and Conventional Banking in ASEAN after the COVID-19 pandemic. The results showed that conventional and Islamic banks had different resilience due to the influence of Capital Adequacy Ratio (CAR) and Loan-to-Deposit Ratio (LDR) factors, but there was no significant difference in the Return on Assets (ROA) and Non-Performing Loans (NPL). Based on the accuracy of the average prediction of 80%, conventional and Islamic bank groups had classification values of 48% and 88%, respectively. This indicated that Islamic financial institutions were more successful than conventional groups in implementing banking resilience.
Photoluminescent and Magnetic Properties of Mononuclear Lanthanide-Based Compounds Containing the Zwitterionic Form of 4-Picolinic Acid as a Ligand
Authors: Areas Esther , Rodrigues Bruno , do Nascimento Ana Carolina , Silva Junior Henrique , Ferreira Glaucio , Miranda Fabio , Garcia Flávio , Safeer Syed , Soriano Stéphane , Guedes Guilherme
Published: September 2023

A series of mononuclear lanthanide-based coordination compounds was obtained under mild synthetic conditions and fully characterized. Single-crystal X-ray diffraction reveals six isomorphic compounds of type [Ln(NO3)(4picH)2(H2O)4](NO3)2 (Ln3+ = Sm (1), Eu (2), Gd (3), Tb (4), Dy (5), Er (6)), in which 4picH is the zwitterionic form of the 4-picolinic acid. Except for compounds 3 and 6, a study into the emissive properties of the compounds was carried out, revealing a ligand-sensitized lanthanide-characteristic luminescence. Compounds 2 and 4 are candidates for luminescent probes in solution. At the same time, the chromaticity data for 5 revealed a potential white-light emitter with a correlated color temperature (CCT) value of 6570 K. Alternating current (AC) magnetic susceptibility measurements, supported by theoretical calculations, showed a field-induced slow relaxation of the magnetization and a single-ion magnet behavior for compound 5.
Biosorbente a base de quitosán-cáscara de naranja, para la remoción de cromo hexavalente en agua
Authors: Fernández Reina Yanay , Sierra Trejo Pamela V. , Patiño Herrera Rosalba , Flores Flores Teresa del C. , González Alatorre Guillermo , Louvier Hernández José Francisco
Published: September 2023

El cromo es uno de los contaminantes más importantes del agua siendo el Cr(VI) el de mayor impacto ambiental. El objetivo de este trabajo es evaluar la capacidad de adsorción de un biosorbente formado por quitosano-cáscara de naranja (CTS-OPW) para eliminar cromo hexavalente del agua. La novedad de este trabajo es la evaluación del efecto del proceso de secado (en horno, en horno de vacío y liofilización) sobre la capacidad de adsorción de cromo. Los adsorbentes se caracterizan mediante difracción de rayos X, espectroscopia FTIR y cinética de adsorción e isotermas midiendo la concentración de Cr(VI) mediante absorción UV-Vis a 540 nm después de formar complejos con 1,5-difenilcarbazida. La capacidad de adsorción se mejora a pH 2,0 y tamaño de partícula OPW de 0.300 micrones. El hombro que aparece a 944 cm-1 después de la adsorción de Cr(VI) en los tres tipos de perlas CTS-OPW indica que el ion cromato se está uniendo al adsorbente. El análisis de chi-cuadrada (χ2) indica que la isoterma de Freundlich se ajusta mejor que la isoterma de Langmuir para todas las perlas CTS-OPW, y que el mejor ajuste para la cinética de adsorción se obtiene con el modelo de Elovich. También se evaluó la capacidad de adsorción de las perlas CTS-OPW para los tres tipos de secado. Se puede concluir que las perlas secadas al horno de vacío tienen la mayor capacidad de adsorción de cromo hexavalente, 33.89 mg g-1, seguidas de las perlas liofilizadas, 32.4 mg g-1, y finalmente las perlas secadas al horno con un valor  de 27.5 mg. g-1.
Projeto ComuSaúde
Authors: Oliveira Marineiva Moro Campos de , Alves Solange Maria
Published: September 2023

O texto em tela materializa parte de pesquisa que vem sendo realizada no âmbito do grupo de pesquisa e como parte de pré-requisitos para obtenção de título de pós-doutorado em educação. Tem como objetivo analisar as estratégias de comunicação utilizada no campo da saúde com idosos não alfabetizados. A partir da perspectiva histórico-cultural do desenvolvimento humano se tece explicitações acerca do projeto ComuSaúde realizado com idosos não alfabetizados moradores de um município do Oeste de Santa Catarina. Por meio de uma pesquisa de abordagem qualitativa, etnográfica, com observações e registros nos momentos de orientações acerca de medicações aos idosos. Como resultados, esta pesquisa destaca o projeto ComuSaúde como uma via de resgate da dignidade humana aos sujeitos frutos da exclusão do direito a apropriação da linguagem escrita.
Matemática, linguagem e letramento
Authors: Cecco Bruna Larissa , Bernardi Luci Teresinha Marchiori dos Santos
Published: September 2023

Este artigo retoma, com base em diferentes autores, a trajetória do conceito de letramento nos estudos sobre leitura e escrita no Brasil. Ancorados nesses estudos, discutimos o letramento matemático e sua (in)finitude, com vistas à transcendência, tendo como horizonte a inconclusão do ser humano, em uma perspectiva freireana. Trata-se de um estudo de base qualitativa, desenvolvido por meio de um ensaio teórico, no qual procuramos contribuir com as análises e discussões sobre o tema. Os resultados mostram a complexidade das áreas que são intrínsecas à matemática, dos níveis e da (in)finitude do letramento matemático escolar e suas ressignificações, desenvolvidas em uma perspectiva de formação crítica. Considera-se que, apesar da finitude do processo de letramento, enquanto tempo de aprendizagem e de definição de conhecimentos durante o processo de escolarização, este pode e deve ser reconstruído e ressignificado ao longo da vida, como um movimento de impermanência da vida humana.
Práticas pedagógicas para sujeitos com diagnóstico de TDAH
Authors: Silva Karina Labes da , Signor Rita de Cassia Fernandes , Tonocchi Rita
Published: September 2023

O objetivo desta pesquisa é apresentar uma revisão integrativa pautada na seguinte questão norteadora: “Quais práticas pedagógicas dirigidas para estudantes diagnosticados com Transtorno de Déficit de Atenção/Hiperatividade (TDAH) são descritas na literatura da área educacional?”. A busca compreendeu artigos completos em língua portuguesa, publicados no período de 2014 a 2018, no Portal de Periódicos da CAPES. A análise dos pressupostos que fundamentaram os nove artigos selecionados indicou duas posições teóricas distintas: 1) centrada em questões orgânico-funcionais e emocionais dos estudantes com TDAH, denominada ‘medicalizante’; 2) voltada para aspectos de história, cultura e interações sociais, designada ‘contextualizada’. Observou-se que, embora as práticas contextualizadas avancem na direção de um planejamento pedagógico voltado à heterogeneidade do público estudantil e promoção do letramento, há escassez de publicações pautadas nesta abordagem. Nessa direção, aponta-se para a necessidade de mais pesquisas considerando a perspectiva sócio-histórica, a fim de expandir o debate sobre o tema estudado.
Práticas que transformam
Authors: Macedo Heloísa de Oliveira , Masini Lucia , Teixeira Vera Regina Vitagliano
Published: September 2023

Este artigo apresenta o relato de atividades terapêuticas fonoaudiológicas que destacam a importância das práticas discursivas, dialógicas, pautadas em referencial histórico-cultural, para o trabalho com a linguagem oral e escrita. O objetivo dos relatos feitos é mostrar que estratégias organizadas, pautadas em escolhas subjetivas de gêneros discursivos diferentes, podem promover a emergência do sujeito de linguagem que inicia o processo terapêutico fonoaudiológico como sujeito patológico. Apresentamos os relatos de quatro crianças, na vivência de dois projetos diferentes (coleção de livros “Eu, autor” e “Painel Interativo”), em que os tempos e relações de cada criança com o outro, consigo e sua linguagem, os diferentes interlocutores discursivos, são subjetivos, mas todos se transformam. Acompanham-nos nessa jornada Bakhtin e Vigotski, em especial, entre outros autores consagrados. Embora sem utilizarmos protocolos formais, as práticas apresentadas podem ser replicadas e evidenciam bons resultados.