bluuebunny/crossref_metadata_2025 huggingface dataset:
Character Education for Elementary School Students: Creative, Ecological Conscious, and Communicative
Authors: Wandari Icha Olvi , Rohana
Published: June 2023

This research aimed at examining character education for elementary school students in the NA.IX-X district is located of North Labuhanbatu Regency in terms of their creative character education, care for the environment, and friendly/communicative character. This research employed qualitative methodby descriptive approach.The sampling technique uses the slovin formula 150 respondents and key informants for grade 5 teachers. The instruments used for research were questionnaires and interviews. Data analysis include data reduction, data analysis, and conclusion drafting. Regarding the application of creative characters in the adequate category with a percentage of 44,53%, it has been demonstrated that students' creative characters are able to ask questions when there are learning difficulties through the use of declarative sentences. If there is content that they do not understand, they will always question the teacher until they do, as it is an added value that teachers provide to students who frequently ask questions. In addition, students' behavior in forming care for the environment behavior in this category is sufficient with a percentage of 75.99% indicating that trash is disposed of properly.Friendly/communicative character with a percentage of 44.53% indicates that elementary school students in Na district IX-X speak politely. According to teacher interviews, teachers constantly monitor students, particularly in terms of communication.
Construction of Discipline of Madrasah Ibtidaiyah Students in PPKn Subjects
Authors: Fradila Noveria , Dahlan Zaini
Published: June 2023

Character education is expected to be the main foundation in the success of a golden generation that is noble, moral, ethical, cultured and civilized based on the Pancasila philosophy. One of the character values that need to be developed is the value of discipline. Discipline character values are very important for students to have other good character values. Discipline is the right way to help students learn to live with good and useful habits. This paper aims to analyze the disciplinary construction of elementary school students in civics subjects. This type of research uses field research with a qualitative descriptive approach, namely a research process that produces descriptive data either in the form of writing or expressions obtained directly from the research field. Data collection techniques were carried out by means of observation, interviews and documentation. Based on the results of research on the Disciplinary Construction of Madrasah Ibtidaiyah Students in Civics Subjects that there are still some students who must be given affirmation regarding the level of discipline, while other students who are able to work well together and follow the applicable rules can change the teaching and learning process to be more conducive and directed through daily habits.
The Wisdom Value of Sanghyang Dedari in Short Film Media to Improve Student Character in Multicultural Studies Courses
Authors: Rupiana I Nyoman Sugita , Suwindia I Gede , Putra I Nyoman Miarta
Published: June 2023

The obstacle in lecture class learning is the difficulty of understanding the learning of the courses. So the right learning media is needed to overcome these problems. This study aims to develop learning media for short films based on the local wisdom of Sanghyang Dedari to improve student character in multicultural studies courses. This type of research is a research and development (RnD) method with a 4-D model design. The sample of this study was determined using a proportional random sampling technique so that a sample of 22 people was obtained. The research instrument used in this product trial was a questionnaire—data analysis techniques using quantitative and qualitative analysis. The pre-test results obtained the lowest score of 56 and the highest score of 77. Post-test results are the lowest score of 80 and the highest score of 92. The effectiveness test results show a significant difference seen from the significance number between the pre-test and post-test scores with a significance value (2-tailed) p equal to 0.000 less 0.05. Based on the results of Paired Sample T-Test testing shows that there is a significant difference between the results of character improvement in pre-test data and post-test data, so from these results, it can also be concluded that through the short film learning media method based on local wisdom Sanghyang Dedari can improve the results of improving student character in multicultural studies courses.
Utilization of Reading Corners in Literacy Activities to Improve Likes to Read Character and Reading Ability of Elementary School Students
Authors: Widyami GA Putu Ayu Suci , Sudiana I Nyoman , Putrayasa Lda Bagus
Published: June 2023

Literacy activities are carried out through habituation activities for all students in the school environment. The lack of use of reading corners makes literacy learning achievements not as expected. This study aims to explore the implementation of the reading corner program, literacy activities, reading skills, and the character of fond of reading elementary school students. This type of research is descriptive explorative with a qualitative approach. Data was collected through interviews, observation, and documentation. The results of the study show that the reading corner program is part of the Bali Danu program, which is an attempt to update the previous program. The collection of books in the reading corner is used as reading material for school literacy activities, and educators use the reading corner as a place for discussion and self-development for students, especially in reading and storytelling activities. Through regular literacy activities and reading corners, students' reading skills and liking to read can be improved. In addition to using the reading corner as a place to read books, the reading corner becomes their class identity; there is a sense of belonging to the reading corner because students are directly involved in creating and maintaining the reading corner.
Forming the Character of Discipline and Responsibility Through Character Education
Authors: Aryadiningrat Intan Nabila Lestari Hakiem , Sundawa Dadang , Suryadi Karim
Published: June 2023

A nation with strong character can become a nation with dignity and respect by other nations in the world. There is a discipline which is a very important character to be applied in the previous educational environment and in tertiary institutions besides the responsibility discipline character education which is very important to be applied in the everyday environment. Seeing the current condition of students, students have experienced a decline in terms of applying the character of discipline and character of responsibility in carrying out lecture assignments. This study aims to analyze the character of discipline and responsibility through character education, describing the views of lecturers in shaping the character of discipline and responsibility in tertiary institutions. The research method used is qualitative research where the data collection technique is to review literature books, journal entries that have something to do with the problem being discussed. The results of the study can be concluded that in the implementation of discipline and responsibility character education for students there are internal and external factors that affect the decline in discipline and loss of student responsibility. One way to remove these obstacles is through habituation which can change the character of student discipline and responsibility. Character education in tertiary institutions is needed to form and develop students to become individuals with character and strengthen the character acquired by students at the previous level.
Kepribadian Toxic People terhadap Kehidupan Era Metaverse
Authors: Nakhma’Ussolikhah  , Kurniawan Ficky Adi , Novianti Cucum , Sulkhah Sulkhah , Marliani Lina
Published: June 2023

Abstrak. Kesalahan yang dilakukan secara sadar dan tidak sadar menjadikan perubahan terhadap aspek keharmonisan hidup. Kegagalan dalam membentuk perilaku positif berdampak pada kekerasan dalam menjalani kehidupan. Pribadi individu bersifat dinamis dan kondisional. Tujuan penelitian ini untuk memahami perbedaan pribadi toxic people dengan pribadi positif atau sifat natural. Metodologi penelitian dengan pendekatan kualitatif desain fenomenologi. Hasil penelitian mendeksripsikan bahwa pribadi individu terbentuk dari pola asuh yang dialami sejak dalam kandungan pranatal sampai usia golden age. Pola asuh toxic dari orang tua yang memberikan dampak negative pada anak membentuk pribadi yang tidak berkembang. Ada tindakan copying untuk membentuk pola perilaku negative. Kebiasaan yang membuat diri individu menjadi pribadi toxic karena lingkungan memiliki pengaruh dominan besar terhadap perubahan perilaku setiap individu. Unsur demikian memiliki stimulus dari adanya modeling pada individu yang memiliki kepribadian kurang harmonis. Indikator dari toxic people diantaranya cenderung temperamental. Keadaan emosi tidak stabil, insecure, kurang percaya terhadap orang lain dan memiliki tingkat kecemasan tinggi. penelitian ini menjelaskan secara detail bahwa pribadi toxic dapat merugikan diri sendiri menjadi kurang berkembang. Kepribadian toxic people kurang disambut baik oleh masyarakat.
 
Abstract. Mistakes made consciously and unconsciously make changes to aspects of the harmony of life. Failure to form positive behavior has an impact on violence in life. The individual personality is dynamic and conditional. The purpose of this research is to understand the personal differences between toxic people and positive personalities or natural traits. Research methodology with a qualitative approach to phenomenological design. The results of the study describe that an individual's personality is formed from the upbringing experienced from the prenatal womb until the golden age. Toxic parenting from parents that has a negative impact on children forms individuals who do not develop. There is an act of copying to form negative behavior patterns. Habits that make an individual become a toxic person because the environment has a large dominant influence on changes in the behavior of each individual. Such elements have a stimulus from the existence of modeling in individuals who have less harmonious personalities. Indicators of toxic people include tending to be temperamental. Unstable emotional state, insecure, lack of trust in others and a high level of anxiety. This research explains in detail that a toxic person can harm oneself by becoming less developed. The personality of toxic people is not well received by society.
Contemporary Arabic Idiomatic Expressions and Methods of Teaching l Al-Ta’birat al-Ishthilahiyyah al-‘Arabiyyah al-Mu‘asharah wa Thara’iqu Ta’limiha
Authors: Wardhana Delly , Bahruddin Uril , Mahmoud Alzitawi Diaya Uddeen Deab
Published: June 2023

This study started from the problem of the difficulty of teaching modern Arabic idioms among students of Babussalam As-Sunnah Institute in Depok. Although proficiency in it is an important part and it has a big role when acquiring the Arabic language fully and completely. This study aimed to reveal the difficulties of the Arabic teaching as well as to clarify the proposed teaching methods for the teaching. This research used a qualitative and descriptive approach, which is an analysis used to collect metadata. This research was conducted at the Babussalam Islamic Boarding School an Educational Institution under the auspices of the Babussalam As-Sunnah Foundation, Cimanggis, Depok, West Java. The results of this study found that difficulties from the point of view of Arabic teachers involved in the study procced from the following main aspects: the educational environment, educational curriculum or in its broadest sense, learners and teachers. The result of the research indicated the proposed teaching methods for teaching modern Arabic idioms from the book, there are: the inductive method, standard method, informative or repeating or speech method and dialogue method.
Arabic Teaching Curriculum for Indonesian General Educational Stages in the Society Era 5.0
Authors: Harisca Rodhy , Muslim Ahmad Bukhari , Moalim Shariif Abdulahi Hussein
Published: June 2023

Arabic is the key to understand Islamic teachings and one of the international world languages of United Nations. However, Arabic learning in Indonesia had not reached the goals of mastering Arabic as a whole yet. The objective of this article was to reformulate Arabic teaching curriculum for Indonesian general educational stages in the society era 5.0. The importunateness of this article was to investigate the  development of Arabic teaching. Descriptive method was adopted in this article. Literature study was used in the data collection technique with four steps by Zed, such as collecting the data, conceptualizing the data, analyzing data and interpreting the data. The source of the data were the three books as the principles of constructive theories in this field; these books are: Manahij al-Lughah al-’Arabiyyah wa Tharaiq Tadrisiha, al-Lughah al-‘Arabiyyah li an-Nathiqin bi Ghairiha Dalil Tathbiqi and Second Language Acquisition. Other related books were also used beside the principle books to arrange the article topic. The article findings indicated that optimizing second language acquisition and developing language skills were the most important things to be a focus supported by technology and media in reformulating Arabic teaching curriculum for Indonesian general educational stages in the society era 5.0. The further research was recommended in reformulating of the Arabic teaching curriculum for each educational stage based on this article findings.
The Development of Assessment Rubric of Arabic Language Writing Based on National Qualifications Framework of Indonesia
Authors: Boeriswati Endry , Mayuni Ilza , Fahmi Ari Khairurrijal , Surong Kamal
Published: June 2023

National qualifications framework of Indonesia needed to be technically elaborated and more operational (KKNI). Academic writing at the university level is difficult to measure without using a rubric. One form of this technique was the creation of an assessment rubric. This article aimed to develop an assessment instrument in the form of a rubric that focused on Arabic academic writing skills for undergraduate students based on the KKNI. The development research method was used with a convergent parallel mixed method model. The data were taken from three tertiary institutions consisting of 1 state university and 2 private universities. Data in the form of needs analysis results, expert analysis, and rubric reliability test results. The results of the trial were compared with the one group pre-test post-test experimental technique to prove that the rubric developed was feasible and reliable for use in teaching Arabic academic writing. The trial process proved that this rubric was feasible to use.  Based on the results of the T test, a result of 0.000 (p 0.05) was obtained. The results of the pretest and posttest experienced significant changes. It could be concluded that the Arabic academic writing rubric based on KKNI that was tested in the UHAMKA, UNJ, and UMSIDA. Arabic Education Study Programs was effective in Arabic academic writing tests. The result of the research was a rubric that can be used for Arabic academic writing in universities. This result was significant to be implemented especially for teachers and lecturers in Arabic writing fields.
The Education in the Face of Contemporary Challenges of Arabic Language Teaching by Al-Shatiby l Al-Tarbiyyah ‘inda al-Syathibi fi Muwajahati al-Tahaddiyat al-Mu‘asharah fi Ta’limi al-Lughah al-‘Arabiyyah
Authors: Nurdianto Talqis , Hajib Zainal Abidin
Published: June 2023

Education is part of human’s life and it may be different in its performance and process according to time and place with its challenges. Educational challenges had made the education scientists and teachers of their efforts and innovation to analyze its problem in order to achieve the desired educational goals. This study aimed to reveal the conditions of education in an era in which Al-Shatiby lived with its challenges, problems, the role in addressing it to society and the possibility of applying his thoughts in teaching the Arabic language to non-native speakers with its challenges in our contemporary era. The educational activities of the Arabic language for non-native speakers face its problems and challenges from the other sides. The descriptive method was used to obtain Al-Shatiby's books related to education, the book of approvals as a basic reference in the study and educational references for the Arabic language. Al-Shatiby was well known as a great educator who was concerned with education and mentor of teachers. Besides, he was a jurist, a renewed fundamentalist and an innovative linguist. According to him, worship was the spirit of education and the seeker of knowledge was concerned with decent ethics. The process of education built on four pillars of education should not be separated such as worthwhile science, productive teacher, desired method, and energized learner.
Pengaruh Customer Engagement dan Pemanfaatan Teknologi BRImo Terhadap Kepuasan Serta Dampaknya Pada Loyalitas Nasabah Bank BRI Kantor Cabang Jelambar
Authors: Kurnia Mochamad Pajar
Published: June 2023

The purpose of this study was to examine and analyze the effect of customer engagement and the use of technology on customer loyalty and customer satisfaction as a mediating variable. The object of this research is the customer of Bank BRI Jalembar Branch Office. The research method used is explanatory research. with the method of determining the sample is purposive sampling with a sample of 100 people. Methods of data collection using online questionnaires and data analysis techniques using SEM-PLS with WarpPLS 6.0 software. The results showed that customer engagement has a significant effect on customer satisfaction. While the use of information technology has no significant effect on customer satisfaction. Customer engagement and customer satisfaction have a significant effect on customer loyalty. While the use of information technology has no significant effect on customer loyalty.
Strategi Komunitas Pedagang Muslim Apem Dalam Menjaga Stabilitas Pendapatan Di Desa Kesesi
Authors: Fitriani Putri Artika
Published: June 2023

Pandemi covid-19 menjadi permasalahan global  yang memberikan dampak pada berbagai sektor , terutama pada sektor perekonomian. Di indonesia sendiri mengalami penurunan perekonomian secara drastis  sebesar 2,07 persen menurut Badan Pusat Statistik (BPS). Selama dua tahun indonesia mengalami pandemi covid-19. Belum mereda sepenuhnya permasalahan lain muncul, yakni permasalahan peraang yang terjadi antara ukraina dan rusia. Hal ini berakibat sektor pangan dunia mengalami krisis. Secara tidak langsung permasalahan tersebut berdampak pada sektor perdagangan, akan tetapi melalui analisis SWOT hal ini tidak berpengaruh besar pada pedagang apem di wilayah Kesesi. Dikarenakan pedagang apem di daerah Kesesi memiliki strategi dalam mempertahankan kualitas produknya sehingga kestabilan pendapatan tetap terjaga. Metode yng digunakan pada penelitian ini adalah penelitian kualitatif karena penulis dalam mengumpulkan datanya dengan melakukan observasi secara langsung ke Desa Kesesi melalui wawancara terhadap beberapa pedagang apem di Desa Kesesi. Hasil penelitian ini adalah strategi yang digunakan para pedagang apem dalam mempertahankan stabilitas pendapatannya dengan cara menjaga kualitas produk apem tersebut.
TIMSS Fen Bilimleri sorularının yenilenmiş Bloom taksonomisi basamaklarına ve Fen Bilimleri dersi öğretim programlarına göre incelenmesi
Authors: TÜRKMEN Müberra , BENZER Semra
Published: June 2023

Araştırmada, 2015 ve 2019 yıllarında TIMSS sınavında çıkan incelenmesine izin verilen, 104 Fen Bilimleri sorusu incelenmiş, TIMSS’te yer alan Fen Bilimleri sorularının ağırlıklı olarak hangi ünitelerden çıktığı tespit edilmiştir. Ünite isimleri ve sınıf seviyeleri FBÖP’larına göre belirlenmiştir. TIMSS 2015 sınavında çıkan 84 Fen Bilimleri sorusu 2013 FBÖP’na göre, TIMSS 2019 sınavında çıkan 20 Fen Bilimleri sorusu 2018 FBÖP’na göre ve yenilenmiş Bloom Taknomisine göre incelenmiştir. Araştırmada doküman analizi yapılmıştır. İncelenen soruların FBÖP’nda yer aldığı sınıf seviyeleri tespit edilmiştir. Bazı soruların ise FBÖP’nda yer almadığı tespit edilmiştir. Çalışmada TIMSS Fen Bilimleri sorularının, Yenilenmiş Bloom Taksonomisi’nin bilişsel süreç boyutuna analizi yapılmıştır. TIMSS Fen Bilimleri sorularının, ağırlıklı olarak alt düzey bilişsel alandan sorulduğu tespit edilmiştir. TIMSS öğrenme alanında yer alan bazı kazanımların FBÖP’nda yer almadığı, bazı kazanımlarınsa verildiği sınıf seviyesi bakımından farklı olduğu tespit edilmiştir. TIMSS döngüsünde daha başarılı olmak adına FBÖP’nda yer alan kazanımların ve verildiği yılların, TIMSS öğrenme alanları kazanımlarıyla paralel olması gerektiği sonucuna ulaşılmıştır.
Efectos de la supervisión escolar sobre la calidad educativa en primaria y secundaria: una revisión sistemática
Authors: Pérez Campuzano María Elena
Published: June 2023

Esta es una revisión sistemática de los estudios (de tipo cuantitativo y cualitativo) que evalúan la supervisión escolar y sus efectos en la calidad educativa. El objetivo del trabajo fue hacer un balance de los efectos generados por la acción supervisora en los centros de educación básica e identificar las prácticas de supervisión que contribuyen o dificultan la mejora educativa, a partir de ello se elaboró una tipología de supervisores según su rol y el impacto observado. Los hallazgos muestran que la supervisión escolar tiene el potencial de impactar en la mejora de la calidad educativa siempre y cuando se desligue de prácticas fiscalizadoras y desarrolle un sistema de acompañamiento para realizar recomendaciones puntuales y brindar apoyo pedagógico en las escuelas.
Występowanie grzybów entomopatogenicznych w glebach siedlisk o zróżnicowanym użytkowaniu
Authors: Majchrowska-Safaryan Anna Barbara , Tkaczuk Cezary , Baj-Wójtowicz Barbara
Published: June 2023

Celem pracy było porównanie składu rodzajowego oraz nasilenia występowania grzybów entomopatogenicznych w glebach pól uprawnych z ochroną chemiczną i bez niej, a wśród nich gleb z systemu uprawy agroleśnej. Materiał do badań stanowiły próby gleb uprawnych pobrane w 2021 r. (wiosna, jesień) w indywidualnym gospodarstwie rolnym o powierzchni 7,42 ha, położonym w miejscowości Kołodziąż, woj. mazowieckie. Obiektami badawczymi bez ochrony chemicznej były próby glebowe pobrane z łąki, zadrzewienia śródpolnego oraz uprawy agroleśnej alejowej (Sosnówka, woj. lubelskie) w 2022 r. Grzyby entomopatogeniczne izolowano, stosując metodę owadów pułapkowych oraz izolacji na podłoże selektywne. W trakcie prowadzonych badań wyizolowano grzyby owadobójcze z rodzajów: Beauveria, Metarhizium i Cordyceps. Oceniając łączne nasilenie oznaczonych rodzajów grzybów owadobójczych w obu terminach badań, stwierdzono, że najwięcej larw owada pułapkowego zainfekowanych było przez grzyby w glebach pobranych z zadrzewień śródpolnych i gleb łąkowych (bez ochrony chemicznej). Przeprowadzone badania wykazały, że w glebach gruntów ornych, na których zastosowano ochronę chemiczną, wyizolowane rodzaje grzybów entomopatogenicznych produkowały mniej jednostek tworzących kolonie (jtk) niż na glebach, na których nie stosowano ochrony chemicznej.
Effect of cropping systems on quantitative changes in prevailing weed species
Authors: Woźniak Andrzej
Published: June 2023

A field experiment was established to evaluate quantitative changes in weed species prevailing in a crop rotation and a 30-year cereal monoculture. The subject of the study included cropping systems: a) crop rotation, and b) cereal monoculture. First (1989–1992) and second (1993–1996) rotation focused on weed infestation of winter triticale in crop rotation and monoculture; third (1997–2000) and fourth (2001–2004) focused on weed infestation of winter wheat; fifth (2005–2008), sixth (2009–2012), seventh (2013–2015) and eighth (2016–2018) focused on weed infestation of spring wheat. The prevailing weed species included: Apera spica-venti, Avena fatua, Galium aparine, Fallopia convolvulus, Stellaria media, Viola arvensis, Anthemis arvensis, Veronica persica, Consolida regalis, and Papaver rhoeas. Among these, A. spica-venti predominated in the winter cereals whereas A. fatua in the spring ones. Numbers of A. spica-venti and A. fatua plants were several times higher in the monoculture than in the crop rotation. The substitution of winter cereals with spring ones in cultivation decreased A. spica-venti population in the spring cereals, but increased the population of A. fatua, particularly in the monoculture.
α1-Adrenoceptor agonist methoxamine inhibits base excision repair via inhibition of apurinic/apyrimidinic endonuclease 1 (APE1)
Authors: Kohutova Aneta , Münzova Dita , Pešl Martin , Rotrekl Vladimir
Published: June 2023

Methoxamine (Mox) is a well-known α1-adrenoceptor agonist, clinically used as a longer-acting analogue of epinephrine. 1R,2S-Mox (NRL001) has been also undergoing clinical testing to increase the canal resting pressure in patients with bowel incontinence. Here we show, that Mox hydrochloride acts as an inhibitor of base excision repair (BER). The effect is mediated by the inhibition of apurinic/apyrimidinic endonuclease APE1. We link this observation to our previous report showing the biologically relevant effect of Mox on BER – prevention of converting oxidative DNA base damage to double-stranded breaks. We demonstrate that its effect is weaker, but still significant when compared to a known BER inhibitor methoxyamine (MX). We further determined Mox’s relative IC
50 at 19 mmol L−1, demonstrating a significant effect of Mox on APE1 activity in clinically relevant concentrations.
Adverse drug reactions in the ambulatory internal patients at the emergency department: Focus on causality assessment and drug-drug interactions
Authors: Verbič Matej Dobravc , Brvar Miran , Kos Mojca Kerec
Published: June 2023

A non-interventional retrospective study in ambulatory patients was conducted at the emergency department of the Division of internal medicine. In 2 months, 266 suspected adverse drug reactions (ADRs) were identified in 224/3453 patients (6.5 %). In 158/3453 patients (4.6 %), an ADR was the reason for emergency department visit and in 49 patients (1.4 %), ADRs led to hospitalisation. A causality assessment algorithm was developed, which included Naranjo algorithm and levels of ADR recognition by the treating physician and the investigators. Using this algorithm, 63/266 ADRs (23.7 %) were classified as “certain”, whereas using solely the Naranjo score calculation, only 19/266 ADRs (7.1 %) were assessed as “probable” or “certain”, and the rest of ADRs (namely, 247/266 = 92.9 %) were assessed as “possible”. There were 116/266 (43.6 %) ADRs related to potential drug-drug interactions (DDIs), stated in at least one of the literature sources used. Based on the causality relationship, the rate of the clinically expressed DDIs was 19.0 %, or 12/63 “certain” ADR cases. Of these, 10 cases presented serious DDI-related ADRs. In summary, ADR causality assessment based exclusively on Naranjo algorithm demonstrated low sensitivity at an ambulatory emergency setting. Additional clinical judgment, including the opinion of the treating physician, proved necessary to avoid under-rating of the causality relationship, and enabled the determination of clinically expressed DDIs.
Rosavin exerts an antitumor role and inactivates the MAPK/ERK pathway in small-cell lung carcinoma in vitro
Authors: Liu Rui , Jiang Cuihong , Zhao Zhizheng , Lv Yutong , Wang Gaoxing
Published: June 2023

This study attempts to explore the function and mechanism of action of rosavin in small-cell lung cancer (SCLC) in vitro. The viability and clone formation of SCLC cells were assessed using cell counting kit-8 and colony formation assays, respectively. Apoptosis and cell cycle were detected using flow cytometry and cell cycle analysis, respectively. Wound healing and transwell assays were performed to evaluate the migration and invasion of SCLC cells. Besides, protein levels of p-ERK, ERK, p-MEK and MEK were determined using Western blot analysis. Rosavin repressed the viability and clone formation of SCLC cells, and promoted apoptosis and G0/G1 arrest of SCLC cells. At the same time, rosavin suppressed migration and invasion of SCLC cells. Moreover, protein levels of p-ERK/ERK and p-MEK/MEK were decreased after rosavin addition in SCLC cells. Rosavin impaired malignant behaviors of SCLC cells, which may be associated with inhibition of the MAPK/ERK pathway in vitro.
Medicarpin induces G1 arrest and mitochondria-mediated intrinsic apoptotic pathway in bladder cancer cells
Authors: Chen Yuan , Yin Liqi , Hao Mingxuan , Xu Wenkai , Gao Jixian , Sun Yuxin , Wang Qiao , Chen Shi , Liang Youfeng , Guo Rui , Zhang Jinku , Li Jinmei , Zhai Qiongli , Cheng Runfen , Wang Jiansong , Wang Haifeng , Yang Zhao
Published: June 2023

Bladder cancer (BC) is the tenth most commonly diagnosed cancer. High recurrence, chemoresistance, and low response rate hinder the effective treatment of BC. Hence, a novel therapeutic strategy in the clinical management of BC is urgently needed. Medicarpin (MED), an isoflavone from Dalbergia odorifera, can promote bone mass gain and kill tumor cells, but its anti-BC effect remains obscure. This study reve aled that MED effectively inhibited the proliferation and arrested the cell cycle at the G1 phase of BC cell lines T24 and EJ-1 in vitro. In addition, MED could significantly suppress the tumor growth of BC cells in vivo. Mechanically, MED induced cell apoptosis by upregulating pro-apoptotic proteins BAK1, Bcl2-L-11, and caspase-3. Our data suggest that MED suppresses BC cell growth in vitro and in vivo via regulating mitochondria-mediated intrinsic apoptotic pathways, which can serve as a promising candidate for BC therapy.
Long-term deprescription in chronic pain and opioid use disorder patients: Pharmacogenetic and sex differences
Authors: Muriel Javier , Escorial Mónica , Margarit César , Barrachina Jordi , Carvajal Cristian , Morales Domingo , Peiró Ana M.
Published: June 2023

More than half of patients with opioid use disorder for chronic non-cancer pain (CNCP) reduced their dose through a progressive opioid withdrawal supported by a rotation to buprenorphine and/or tramadol. The aim of this research is to analyse the long-term effectiveness of opioid deprescription taking into account the impact of sex and pharmacogenetics on the inter-individual variability. A cross-sectional study was carried out from October 2019 to June 2020 on CNCP patients who had previously undergone an opioid deprescription (n = 119 patients). Demographic, clinical (pain, relief and adverse events) and therapeutic (analgesic use) outcomes were collected. Effectiveness (< 50 mg per day of morphine equivalent daily dose without any aberrant opioid use behaviour) and safety (number of side-effects) were analysed in relation to sex differences and pharmacogenetic markers impact [OPRM1 genotype (rs1799971) and CYP2D6 phenotypes]. Long-term opioid deprescription was achieved in 49 % of the patients with an increase in pain relief and a reduction of adverse events. CYP2D6 poor metabolizers showed the lowest long-term opioid doses. Here, women showed a higher degree of opioid deprescription, but increased use of tramadol and neuromodulators, as well as an increased number of adverse events. Long-term deprescription was successful in half of the cases. Understanding sex and gender interaction plus a genetic impact could help to design more individualized strategies for opioid deprescription.
Germline variants of the genes involved in NF-kB activation are associated with the risk of COPD and lung cancer development
Authors: Baranasic Jurica , Niazi Yasmeen , Chattopadhyay Subhayan , Rumora Lada , Ćorak Lorna , Dugac Andrea Vukić , Jakopović Marko , Samaržija Miroslav , Försti Asta , Knežević Jelena
Published: June 2023

Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are closely related diseases associated with smoking history and dysregulated immune response. However, not all smokers develop the disease, indicating that genetic susceptibility could be important. Therefore, the aim of this study was to search for the potential overlapping genetic biomarkers, with a focus on single nucleotide polymorphisms (SNPs) located in the regulatory regions of immune-related genes. Additionally, the aim was to see if an identified SNP has potentially an effect on proinflamma-tory cytokine concentration in the serum of COPD patients. We extracted summary data of variants in 1511 immune-related genes from COPD and LC genome-wide association studies (GWAS) from the UK Biobank. The LC data had 203 cases, patients diagnosed with LC, and 360 938 controls, while COPD data had 1 897 cases and 359 297 controls. Assuming 1 association/gene, SNPs with a p-value < 3.3 × 10–5 were considered statistically significantly associated with the disease. We identified seven SNPs located in different genes (BAG6, BTNL2, TNF, HCP5, MICB, NCR3, ABCF1, TCF7L1) to be associated with the COPD risk and two with the LC risk (HLA-C, HLA-B), with statistical significance. We also identified two SNPs located in the IL2RA gene associated with LC (rs2386841; p = 1.86 × 10−4) and COPD (rs11256442; p = 9.79 × 10−3) but with lower significance. Functional studies conducted on COPD patients showed that RNA expression of IL2RA, IFNγ and related proinflammatory cytokines in blood serum did not correlate with a specific genotype. Although results presented in this study do not fully support our hypothesis, it is worth to mention that the identified genes/SNPs that were associated with either COPD or LC risk, all were involved in the activation of the NF-κB transcription factor which is closely related to the regulation of the inflammatory response, a condition associated with both pathologies.
The Role of Music Education in Childhood
Authors: Szűcs Tímea , Juhász Erika
Published: June 2023

Introduction:
From the second half of the 20th century onwards, studies on the transfer effects of music learning have become increasingly common. Both in the domestic and international literature, we can read research with a solid scientific background that supports the transfer effects of music education on different aspects of life.

Purpose:
The aim of paper was to map the effect of learning music in childhood based on both the international and the Hungarian scientific literature.

Methods:
When analyzing the social impact of learning music in detail we distinguished five areas: 1. state of physical development, skillfulness, health; 2. cognitive skills; 3. personal development and emotional intelligence; 4. the role of compensating for deficit; 5. community building. In this study we present in detail the results of research studies in these fields.

Conclusions:
In our opinion music education institutions transmit several values and hidden curriculum to children the effect of which serves as a determining and formative factor throughout their whole lives. That is why it is important that, based on the research findings, teachers should be aware of it and consciously control it. In our view learning music can act as a supporting factor for the physical, spiritual and mental development of the children and apart from improving different areas of competence it can also influence their attitude to work.
Model for Reinvestment Policy in Risk-Free Assets with Various Maturities
Authors: Stoilov T. , Stoilova K. , Kanev D.
Published: June 2023

Logistic tasks are aimed at the optimal distribution of material, energy, financial and human resources. This research has a narrow field aimed at optimal management of financial resources and their redistribution. Specifically, a reinvestment policy model is derived by maximizing the profit of a business entity. Reinvestment is done with risk-free assets, but they have different maturity periods. This makes it difficult to assess the optimal investment strategy, as reinvestment can be done at the end of the maturity period. This study develops a model for a dynamic control process, which leads to the formalization of a discrete integer time optimization problem. Its solution gives a sequence of investments and a total optimal return. The solution to the problem is illustrated in an EXCEL environment. The added value of this study stems from the formalization and quantification of the model for the reinvestment strategy in the optimization problem.
Cryptocurrency Price Prediction Using Enhanced PSO with Extreme Gradient Boosting Algorithm
Authors: Srivastava Vibha , Dwivedi Vijay Kumar , Singh Ashutosh Kumar
Published: June 2023

Due to the highly volatile tendency of Bitcoin, there is a necessity for a better price prediction model. Only a few researchers have focused on the feasibility to apply various modelling approaches. These approaches may prone to have low convergence issues in outcomes and acquire high computation time. Hence a model is put forward based on machine learning techniques using regression algorithm and Particle Swarm Optimization with XGBoost algorithm, for more precise prediction outcomes of three cryptocurrencies; Bitcoin, Dogecoin, and Ethereum. The approach uses time series that consists of daily price information of cryptocurrencies. In this paper, the XGBoost algorithm is incorporated with an enhanced PSO method to tune the optimal hyper-parameters to yield out better prediction output rate. The comparative assessment delineated that the proposed method shows less root mean squared error, mean absolute error and mean squared error values. In this aspect, the proposed model stands predominant in showing high efficiency of prediction rate.
Research on the Knittability of Metallic Yarns in the Warp-knitted Mesh of a Deployable Antenna
Authors: Haiyan Xu , Nanliang Chen , Jinhua Jiang
Published: June 2023

Metallic yarns are difficult to be knitted. To resolve the problem, the paper used the knitted yarn strength utilization factor to quantitatively characterize knittability, which was the ratio of yarn strength after being knitted to that of the original yarns. Furthermore, the relationship between the yarns' basic mechanical properties and the knitted yarn strength utilization factor was investigated by testing the yarns' basic mechanical properties. The results showed that it was feasible to quantitatively characterize the yarns' knittability using the knitted yarn strength utilization factor. And also the breaking strength of yarn was not correlated with the knittability. The elongation at break of the yarn was positively correlated with knittability. The bending stiffness of the yarn was negatively correlated with the knittability. Finally, a multiple linear regression model of the knittability and the mechanical properties of the yarn was developed. The model showed that there was a significant linear relationship between knittability and the elongation of yarns at break and the bending rigidity of yarns, with the bending stiffness of yarns being more significant.
Structural, morphological, and optical properties of AgxO thin films deposited via obliquely angle deposition
Authors: Soltane H. Ben , Akkari F. Chaffar , Gallas B. , Kanzari M.
Published: June 2023

This work reports on the optical, structural, and morphological properties of silver oxide thin films obtained by postoxidation of silver deposited previously by the thermal evaporation technique. The samples were deposited on glass substrates using the oblique angle deposition technique for different angles of incidence γ (γ=0°, 20°, 40°, 60°, 75°, and 85°). γ is defined as the angle between the particle flux and the normal to the substrate. The resulting thin films were annealed in the free air at two temperatures (300°C and 400°C). X-ray diffraction (XRD), scanning electron microscopy (SEM), and UV-visible-NIR spectrophotometer were performed to study the crystal structure, as well as the morphological and optical properties (transmittance and reflectance), of the AgxO samples. X-ray diffraction analysis revealed the presence of the AgxO phase for the silver films deposited at a high angle of incidence and for the annealing temperature 300°C. In contrast, the diffractograms of the silver films annealed at 400°C show an amorphous behavior. Optical results indicated that the direct band gap energy increases pursuant to increasing the angle of incidence γ. The absorption coefficients of AgxO thin films were found to be in the range of 103–105 cm−1. Additionally, we determined the birefringence for the layers annealed at 400°C and found that the highest value of birefringence is obtained corresponding to the angle of incidence 60°. Morphological analysis indicated that the porosity increases with the angle of incidence and highlights the amorphous nature of the films, which is attributed to the columnar structure.
Heart failure complicating myocardial infarction: incidence, risk factors at a tertiary care hospital in Jeddah, Saudi Arabia
Authors: Sheikh Anas , Alshehri Abdulaziz , Alsheikh Abdulaziz , Ramadan Salah , Ganbou Zeyad , Dawood Muhannad , Farid Abdullah , Bayazed Abdullah
Published: June 2023

Objective:
This study aimed to determine the risk factors and the prevalence of heart failure (HF) complicating myocardial infarction (MI) at King Abdulaziz University Hospital in Jeddah, Saudi Arabia.
Methods:
A retrospective study was conducted on a convenient sample of patients diagnosed with heart failure from February to August' 2022. Patients aged 18-70 years at the time of diagnosis were included. Data about patients' demographics, BMI, smoking, chronic diseases, arrhythmias, ischemic cardiovascular events, arteries occluded, infarct location, peak troponin level, STEMI or NSTEM history, intervention and follow ups were collected.
Results:
The mean age of the studied 307 HF patients was 56.6 ± 10.15 years and 61.6% were males. Of them, 106 (34.5%) had associated MI. Only 16.3% were current smokers and 94.1% had comorbidities, most commonly hypertension (81%) and diabetes (75.1%). The majority (68.1%) had a reduced ejection fraction (=
Evaluation of Interprofessional Quality Improvement Interventions Led by an Ambulatory Care Pharmacist on Adherence to a Controlled Substance Agreement Policy
Authors: Mohammad Insaf , Alsomairy Sarah , Mawari Mona , Elabdallah Mohamad , Elteriefi Ruaa , George Julie
Published: June 2023

Background: A controlled substance agreement (CSA) is a risk mitigation strategy for patients managed on controlled substance medications such as opioids and benzodiazepines. Limited literature exists to describe the role of the clinic pharmacy team to promote adherence to CSA monitoring parameters.  
Objective: The objective of this study is to evaluate the impact of interprofessional educational and clinical interventions led by an ambulatory care pharmacist on adherence to monitoring parameters within a CSA policy. 
Methods: This retrospective observational study included patients on long-term controlled substances who had a clinic visit every 3 months during the study period. The primary outcomes were the proportion of patients with a signed CSA in the electronic medical record (EMR), urine drug screen (UDS) completion, and documentation of review of the statewide prescription drug monitoring program (PDMP) in the EMR 8 months prior to as compared to 8 months after implementation of pharmacist interventions. Results: Among 79 patients (mean age 55.7 years, 65.8% female, 54.4% African American), 8.9% pre- vs 88.6% post-interventions had a signed CSA (p<0.001), 35.4% pre- vs 65.8% post-interventions had a UDS completed (p<0.001), and 32.9% pre- vs 57% post-interventions had documentation of PDMP review (p=0.002).
Conclusion: Adherence to monitoring parameters within a CSA policy significantly improved after educational and clinical interventions led by an ambulatory care pharmacist.
Effect of postharvest application of plant powders on physical quality and shelf life of okra during storage in Makurdi
Authors: Iorliam Iveren Blessing , Ugoo Tavershima Richard
Published: June 2023

The effect of postharvest application of plant leaf powders on the physical quality and shelf life of okra fruits during Storage in Makurdi was determined. Moringa and Neem leaf powders were used to coat the okra fruits, which were then kept at room temperature. The experiment was a 2 x 3 factorial combination of treatments, fitted in a completely randomized design, and replicated thrice. Data collected were subjected to Analysis of variance (ANOVA) using GENSTAT statistical package, and Fisher’s Least Significant Difference (F-LSD) at a 5% level of probability to separate the means. Results revealed that plant leaf powders of Azadirachta indica (Neem) and Moringa oleifera have the ability to enhance the shelf life and maintain the physicochemical quality of okra fruits under storage. These powders also have the potential to be antifungal. Among the okra varieties studied, Clemson spineless gave better physical quality as compared to stubby okra thus the shelf life during storage. Treated okra shelf life extended to day 15 whereas the untreated fruits ranged from 1 - 7 days. These botanicals offer alternatives for maintaining crop management and postharvest physiology in addition to being safe for consumers, inexpensive, easy to create, and easy to apply formulations. It is therefore recommended the use of plant leaf powders particularly M. oleifera for the storage of okra fruits in Makurdi.
" The Justice and Development Party and the Challenge of Transitioning to a Presidential System in Turkey: A Vision for Political Analysis and Confronting Challenges
Authors: Ahmed Adnan Kazim  , Jassim Mohammed Ahmed
Published: June 2023

The Turkish governments had witnessed dramatic changes during several decades ,So the article researched in realistic situations to estimate the contemporary events according to what happened now a days .Therefore , many challenges must be tackled in order to assessment the political scene specially after several military intervention in political life ,So these developments required making of amendments in constitutional law to change the political system toward presidential order instead of parliamentary system , and this  was happened in constitutional amendments which hold in sixteenth of April 2017 as a result of it .Turkish policies were stable politically and lawfully according to practicing democracy ,and it could be easily to know the nature of political participation as followed constitutionally .So the potentially strongest forces are being enabled to renew the political elites ,and the economic miracle would redistribution of roles among active actors in political life .Erdoğan's supporters point out since the attempted coup which happened in amid of July 2016 ,So the governing party and its government tried to reconstruction of trust between the peoples and political elites mutually , in order to override all challenges and to  stabilize the process of democracy.
"The Consequences of UK withdrawal from the European Union
Authors: Bakhan Ako Najmalddin
Published: June 2023

The European Union is the most important development in European history since World War Two. Nothing else has had such a broad, deep, and lasting effect on the lives of Europeans. The topic of Europe has been a source of tension in the UK. The UK has long been one of the most skeptical and ambivalent members of the 28-country European Union (EU). The EU, the rest of Europe, allies around the world and the UK itself need to be prepared for the wider international implications of such a move. The approaching referendum on whether the United Kingdom should remain in or leave the European Union marks a defining moment for the country’s foreign relations. In addition to determining the UK’s future status in Europe, it will affect Britain’s ability to thrive in and help shape a rapidly changing world.