bluuebunny/crossref_metadata_2025 huggingface dataset:
Knowledge About Obstetric Hazard Signs and Associated Factors Among Reproductive Age Women in South Eastern Zone of Tigray 2021. Cross Sectional Study
Authors: Asfaha Berhane Teklay , Gebremariam Shewit Hailu , Gebremariam Gebremedhin Kinfe , Weldemariam Ataklti Gebretsadik
Published: January 2022

Background: Pregnancy complications are the biggest health problem for women in developing countries. Around 295,000 women worldwide die each year from pregnancy-related causes, and 86% of this maternal mortality occurs in developing countries.Objective: To assess knowledge about obstetric hazard signs among women of reproductive age living in the southeastern zone of the Tigray region, Ethiopia, 2021.Methods: A community-based quantitative cross-sectional survey was conducted in the southeastern zone of Tigray. A multi-level random sampling technique was implemented to select the total participants from 410 women of reproductive age. Two districts were selected at random and from these districts 12 Kebels were selected at random and the calculated sample size (410) was proportionally assigned to each Kebele selected. The data was collected through face-to-face / interview with a structured questionnaire from January 20 to February 20, 2021, after it had been ensured that all ethical requirements were met. The collected data was entered into Epidata version 4.2 and then exported to SPSS version 20 for analysis. Descriptive statistics with frequency, percentage, table and graph as well as crosstabs were used to present the results. Bivariate and multivariable analyses were used to examine the relationship. Odds ratios with 95% confidence intervals and P-values ​​<0.05 were used to determine the statistical association.Result: Four hundred and ten women of childbearing age participated in the study, which resulted in a response rate of 100%. Leakage of fluid per vagina was the most frequently cited obstetric hazard sign (61%). Overall, one hundred and seventy-two (42%) had a good knowledge of obstetric hazard signs. Educational status of the mother [AOR (95% CI = 2.7 (1.189–6.24)], place of birth [AOR (95% CI = 2.2 (1.6–3.432)] and with a history of ANC follow-up [AOR (95% CI = 2.4 (1.13–5.6)] were found to be independent predictors of women's knowledge of the obstetric hazard sign.Conclusion and recommendation: The mother's educational status, birth site and the history of ANC follow-up were independently related to the women's knowledge of obstetric hazard signs. Therefore, the provision of information, education and communication to women, families and the general community about obstetric hazard signs and related factors has been recommended.
LncRNA-UC.25+ ShRNA Alleviates P2Y14 Receptor Mediated Diabetic Neuropathic Pain Via STAT1
Authors: Wu Baoguo , Zhou Congfa , Xiao Zehao , Tang Gan , Guo Hongmin , Hu Zihui , Hu Qixing , Peng Hao , Pi Lingzhi , Zhang Zhihua , Wang Miaomiao , Peng Taotao , Huang Jiaqi , Liang Shangdong , Li Guilin
Published: January 2022

Diabetic neuropathic pain (DNP) is a common complication of diabetes, and its complicated pathogenesis as well as clinical manifestations has brought great troubles to clinical treatment. The spinal cord is an important part of regulating the occurrence and development of DNP. Spinal microglia can regulate the activity of spinal cord neurons and have a regulatory effect on chronic pain. P2Y12 receptor is involved in DNP. P2Y14 and P2Y12 receptor belong to the Gi subtype of P2Y receptors, but there is no report that P2Y14 receptor is involved in DNP. Closely related to many human diseases, the dysregulation of lncRNA has the effect of promoting or inhibiting the occurrence and development of diseases. The aim of this research is to investigate the function of spinal cord P2Y14 receptor in type 2 DNP and to understand the function as well as the possible mechanism of lncRNA-UC.25+ (UC.25+) in rat spinal cord P2Y14 receptor-mediated DNP. Our results showed that P2Y14 shRNA can reduce the expression of P2Y14 in DNP rats, thereby restraining the activation of microglia, decreasing the expression of inflammatory factors and the level of p38 MAPK phosphorylation. At the same time, UC.25+ shRNA can down-regulate the expression of P2Y14 receptor, reduce the release of inflammatory factors, and diminish the p38 MAPK phosphorylation, indicating that UC.25+ can alleviate spinal cord P2Y14 receptor-mediated DNP. The RNA immunoprecipitation result showed that UC.25+ enriched STAT1 and positively regulated its expression. The chromatin immunoprecipitation result indicated that STAT1 combined to the promoter region of P2Y14 receptor and positively regulated the expression of P2Y14 receptor. Therefore, we infer that UC.25+ may alleviate DNP in rats by regulating the expression of P2Y14 receptor in spinal microglia via STAT1.
Effects of Selective Alveolar Decortication on the Periodontal Complex
Authors: Lim Ju-Eun , An Jung-Sub , Lim Won Hee
Published: January 2022

Background

Modification of bone turnover has been reported following selective alveolar decortication but the molecular signals in the periodontal ligament space (PDL) remain unanswered. The objective of this study was to understand how selective alveolar decortication affects the biological reactions in the periodontal ligament.
Methods

Selective alveolar decortication in wild-type mice (n=25) was performed on mandibular right buccal cortical plate adjacent to the mandibular right third molar and euthanized at 3, 7, 14 and 28 days. We also performed selective alveolar decortication in Lrp5ACT (n=5) mice and Ad-Dkk1 treated mice (n=5), and euthanized at 7 days. The periodontium around the mandibular third molars were examined using histology, immunohistochemical analyses for osteogenic markers, TGF-β, RANKL, TRAP and alkaline phosphatase activity.
Results

The expression of osteogenic markers in the wild-type PDL was maintained during healing time period after selective alveolar decortication. Increased osteoclast activity in the wild-type mice was observed at 3 and 7 days after selective alveolar decortication. The PDL in Lrp5G171V (Lrp5ACT) mice and adenovirus Dkk1 (Ad-Dkk1) treated mice also showed insignificant changes in the expression of osteogenic markers following selective alveolar decortication. In Lrp5ACT mice where there was a reduction of bone resorption, selective alveolar decortication caused a dramatic increase in osteoclast activity.
Conclusions

Selective alveolar decortication affects only bone turnover, but not the expression of osteogenic markers in the PDL.
Application Value of Contrast-Enhanced Ultrasound In The Diagnosis of Intermediate Trophoblastic Tumours
Authors: Zhu XiaoDan , Hu Yin , Zhou LinYu , Jiang TianAn
Published: January 2022

Background: As the rarest gestational trophoblastic neoplasia (GTN), intermediate trophoblastic tumours (ITTs) are very difficult to diagnose before surgery due to the lack of specificity of clinical manifestations. Routine colour Doppler ultrasonography is currently the simplest and reproducible imaging method for diagnosing ITTs, but it is not as specific as other tumours. Through the research and analysis of colour Doppler ultrasound images (CDFI) and contrast-enhanced ultrasonography (CEUS) images of ITTs, the ultrasound characteristics and CEUS perfusion characteristics are summarized, and these findings can provide a reference for the correct diagnosis of ITTs.Methods: Seven ITT patients were diagnosed and treated in our institution from January 2016 to August 2020, and the clinical data of all patients were retrospectively collected and analysed. Two sonographers who had worked for more than 5 years analysed the characteristics of the ultrasound and CEUS. Among them, the characteristics of CEUS are summarized and analysed from the four aspects of contrast enhancement method, time, boundary, and intensity. All cases were diagnosed with pathological support by ITTs.Results: The most common clinical symptoms of ITT are vaginal bleeding and amenorrhea. The serum ß-human chorionic gonadotropin (serum-hCG) level was mainly a low-grade increase, but to determine whether the serum-hCG level can be used as one of the indicators for monitoring ITT recurrence or metastasis, a large sample data analysis is needed. The lesion location, internal echo changes, and blood flow signals of ITTs were not significantly specific compared with those of other GTNs. However, the CEUS performance of ITTs has certain characteristic changes, in which the enhancement mode was mainly regional enhancement, the arterial phase showed slow, equal-slightly high enhancement, and the enhanced bounders were not very clear. Compared with the CEUS performance of other GTNs, it has a certain specificity.Conclusions: Certain characteristic changes in CEUS of ITTs, combined with clinical features, can provide help for the accurate diagnosis of ITT.Trial registration: For non-clinical or non-health care intervention on human participants of what the article reports.
Pendampingan Pelestarian Kearifan Lokal Reog Kendang: Upaya Pendidikan Karakter dan Ketrampilan Seni pada Siswa Sekolah Dasar Sidomulyo Pagerwojo Tulungagung
Authors: Nurhayati Dwi Astuti Wahyu
Published: January 2022

Penelitian ini disajikan untuk mengetahui bagaimana merevitalisasi nilai-nilai kearifan lokal dan ketrampilan seni tari Reog Kendang pada saiswa-siswa sekolah dasar Sidomulyo tentang pentingnya memliki ketrampilan pada kegiatan ekstrakurikuler pada seni tari.Data dikumpulkan selama 2 bulan mulai dari Januari hingga Februari 2019 di sekolah Dasar Sidomulyo Pagerwojo di Tulungagung. Data dikumpulkan melalui observasi dan wawancara. Penelitian ini melibatkan siswa-siswa yang didampingi oleh peneliti untuk melestaraikan tari Reog Kendang sebagai seni tari dan salah satu kearifan lokal masyarakata setempat. Subjek penelitian terdiri dari 65 siswa yang memiliki informasi relevan tentang tema penelitian Temuan ini mengungkapkan bahwa ada beberapa anak yang belajar tari Reog Kendang bertindak sebagai pelaku tari sebagai ketrampilan seni tari berlatih, mendiskusikan simbol tari dengan teman-temannya dan bertanya jawab dengan peneliti tentang makna dan sejarah tari Reog Kendang. Hasil dari penelitian ini juga diperoleh beberapa perspektif anak-anak dalam mempraktekkan tari Reog Kendang sebagai media pembelajaran untuk merevitalisasi nilai-nilai sejarah,moral dan sosial. Beberapa tanggapannya adalah: meningkatkan pengabdian kepada negara, mengajarkan bagaiamana berperilaku baik, jujur dalam kehidupan bermasyrakat, belajar dan disiplin, berlatih untuk beranggungjawab, meneladani sejarah pahlawan regional dan nasional, saling menghargai  ketika berproses baik ketika berlatih tari,mengembangkan ketrampilan seni, menciptakan seni dan menampilkan karya seni terbaik bagi desa pada saat perpisahan, bersih desa,pembukaan acara di desa dan kecamatan. Selain itu, ditemukan juga perspektif anak-anak dalam berlatih tari, menguasai seni trai Reog Kendang sebagai media pembelajaran: menyampaikan pelajaran melalui tari dan berlatih secara langsung serta memahami makna dalanm setiap gerakan lebih menarik, termotivasi, menambah pengetahuan, dan menghibur bukan hanya untuk penari akan tetapi juga penikmat seni.
Analysis of Mathematics Problem Solving Ability of Junior High School Students in Solving Problems in Online Learning
Authors: Simanungkalit Rick Hunter , Peranginangin Renita Br
Published: January 2022

This study aims to determine the mathematical problem solving ability of students in solving story problems with online learning. The method in this study used a qualitative descriptive research method. The results showed that there were differences in the ability to identify the elements that were known and asked, there were differences in the ability to choose and apply strategies or problem solving procedures and there were differences in the ability to examine and explain the results or answers according to problems between students with high, medium mathematical problem solving abilities. and low. There are 43% of students who have been able to follow and adapt online learning while 57% of other students have difficulty understanding the material being taught. There are 60.86% of students who have a high enough enthusiasm in online learning (online) but 39.13% of students are not happy if learning mathematics is done online due to factors that influence it such as technical constraints. There are 73.91% of students with a positive response to the problem of mathematical problem solving ability even though the learning is carried out online and 26.08% of students with a negative response.
Analisis Literasi Sains Mahasiswa Calon Guru IPA Tingkat Pertama ditinjau dari Latar Belakang Pendidikan SMA dan SMK
Authors: Latip Abdul , Rahmaniar Andinisa , Burhanudin B , Permatasari Devi
Published: January 2022

Penelitian ini bertujuan untuk menganalisis dan mendeskripsikan kemampuan literasi sains mahasiswa calon guru IPA tingkat pertama ditinjau dari latar belakang pendidikannya, yaitu SMA dan SMK. Metode deskriptif kuantitatif digunakan dalam penelitian ini dengan melibatkan 37 mahasiswa calon guru IPA tingkat pertama sebagai sampel yang dipilih secara random. Instrumen penelitian yang digunakan terdiri dari 20 soal literasi sains yang mengukur domain literasi sains, yaitu pengetahuan sains dan kompetensi sains yang dibangkai dengan konteks tertentu. Hasil penelitian menunjukkan: 1) Skor rata-rata literasi sains mahasiswa calon guru IPA berlatar belakang pendidikan SMA pada literasi sains secara keseluruhan dan setiap domain literasi sains lebih besar daripada mahasiswa calon guru IPA berlatar belakang SMK, 2) Secara umum, literasi sains mahasiswa calon guru IPA tingkat pertama berada pada kategori sedang. Hasil tersebut menunjukkan bahwa kemampuan literasi sains mahasiswa calon guru IPA ditinaju dari latar belakang pendidikanya perlu ditingkatkan melalui berbagai kegiatan perkuliahan yang mengarah pada literasi sains
Prioridades en la formacion universitaria que promuevan la retencion laboral, perspectiva del profesional de salud en Ayacucho
Authors: Miranda Ramón Eva Iliana , Zeladita-Huaman Jhon Alex , Ronceros Medrano Sergio Gerardo
Published: January 2022

Objetivo: Analizar las prioridades en la formación universitaria que promuevan la retención laboral, perspectiva del profesional de salud en Ayacucho. Materiales y métodos: El presente estudio es de enfoque cualitativo, y en cuanto a su diseño metodológico es un estudio descriptivo. La población fue de 656 participantes siendo profesionales de la salud y siendo el tamaño de la muestra de 90 participantes. Se realizaron entrevistas semiestructuradas a 90 profesionales que laboran en establecimientos de salud de tres redes de salud ubicados en distritos de extrema pobreza. Las declaraciones fueron analizadas mediante el análisis temático y se empleó el marco teórico de la Organización Mundial de la Salud. Resultados: Emergieron cuatro categorías: La formación universitaria de los profesionales de la salud debe estar basada 1) en prioridades sanitarias, 2) el trabajo con la comunidad y la prevención comunitaria, 3) la gestión de servicios de salud y 4) la formación interprofesional, habilidades sociales y promoción profesional. En cuanto al tipo de profesión, 41% (n=37) eran Enfermeras, 36% (n=32) eran Obstetras y 23% (n=21) eran Médicos. Conclusiones: Las universidades que forman profesionales de la salud deben implementar estas recomendaciones para favorecer la atracción y retención del personal en áreas rurales y que brinda atención de salud a población de extrema pobreza.
Immunity, Vascular Aging and Stroke
Authors: Louka Anna-Maria , Sagris Dimitrios , Ntaios George
Published: January 2022

Stroke is one of the most devastating manifestations of cardiovascular disease.
Growing age, arterial hypertension, and atherosclerosis are identified as independent risk
factors for stroke, primarily due to structural and functional alterations in the cerebrovascular
tree. Recent data from in vitro and clinical studies have suggested that the immune
system influences atherosclerosis, promoting vascular stiffness and vascular aging and
contributing to ischemic stroke, intracranial haemorrhage and microbleeds, white matter
disease, and cognitive decline. Furthermore, aging is related to a chronic low-grade inflammatory
state, in which macrophage, neutrophils, natural killer (NK cells), and B and
T lymphocytes act as major effectors of the immune-mediated cell responses. Moreover,
oxidative stress and vascular inflammation are correlated with endothelial dysfunction,
vascular aging, blood-brain barrier disruption, lacunar lesions, and neurodegenerative disorders.
This review discusses the pathophysiological roles of fundamental cellular and
molecular mechanisms of aging, including the complex interplay between them and innate
immunity, as well as vascular dysfunction, arterial stiffness, atherosclerosis,
atherothrombosis, systemic inflammation, and blood-brain barrier dysfunction.
Synthesis of 5(S)-Methyl-L-Proline Containing Peptidomimetic Compounds
and their In Vitro Evaluation for Dipeptidyl Peptidase-4 Inhibition
Authors: Gajjar Anuradha K. , Pathak Chirag D.
Published: January 2022

Background:

Type 2 diabetes mellitus (T2DM), which is the epidemic of the 21st century, has
affected millions of people worldwide. Traditional methods available for the treatment are associated with
various side effects. Among the newer therapies, DPP-4 (Dipeptidyl peptidase-4) inhibition has been a
promising therapy for the past decade with the scope of further development, especially in peptidomimetics.

Objective:

5(S)-methyl-L-proline containing peptidomimetic compounds were designed in the previous
work. The designed compounds were synthesized and characterized by spectral methods, such as mass
spectrometry, 1H NMR, and 13C NMR (Nuclear magnetic resonance) spectroscopy. The purity of the final
compounds was determined by high-performance liquid chromatography (HPLC). The synthesized compounds
were in vitro evaluated for their DPP-4 inhibitory activity.

Method:

Compounds were peptide in nature and were synthesized using the conventional synthesis approach,
where peptide synthesis was done using an acid-amine coupling reagent. They were evaluated
through fluorimetric enzyme-based assay using a DPP-4 inhibitor screening kit. Moreover, the CLARIOstar
microplate reader instrument was used to measure fluorescence.

Results:

5(S)-methyl-L-proline containing 13 compounds were synthesized. All of them were characterized
for structural integrity using spectral methods. They had HPLC purity of more than 95% and were
evaluated for DPP-4 inhibition. Compounds 1, 7, 10, 11, 14 and 17 were found to have good inhibition
than others. These compounds were further evaluated at different concentrations to develop a linear correlation
coefficient (R2).

Conclusion:

Six compounds were found to have good DPP-4 inhibition, hence it further opens the possibility
of developing DPP-4 inhibitor-containing 5(S)-methyl-L-proline.
Severity Evaluation of Regional Cerebrovascular Reactivity in Acute
Stroke Patients Using SPECT
Authors: Kang Chang-Ki , Song Min-Gyu , Yang Jiwon , Lee Haejun , Lee Yeong-Bae
Published: January 2022

Background:

Cerebrovascular reactivity (CVR), as measured using perfusion single photon
emission computed tomography (SPECT), is an important indicator for the treatment and prognosis
of cerebrovascular disease, but there are a few studies on acute stroke or small vascular disease
using SPECT.

Objective:

This study evaluated the regional severity with quantitatively determined CVR in patients
with acute stroke.

Method:

Fifty-eight patients who took brain SPECT images were selected to localize quantitative
CVR values. The severity of the disease (Grade 1 to 4) was determined through image-based clinical
assessment in the absence and presence of a CVR map, and their results were compared.

Results:

In 1st diagnosis without the map, the mean CVR values of Grades 2 and 3 were -6.07 %
and -9.12 %, respectively (P=0.034), while they were -4.78 % and -12.34 % in 2nd diagnosis with
the map, respectively (P<0.001), suggesting that the CVR difference with the map was much more
pronounced than without the map. Furthermore, in the ROC analysis, the diagnostic sensitivity between
Grades 2 and 3 in the 2nd diagnosis (AUC=0.899, P<0.001) was substantially greater than
the 1st diagnosis (AUC=0.646, P=0.048).

Conclusion:

This study demonstrated that the quantitative CVR maps could reinforce the clinical
evaluation of cerebral severity by showing that they can provide statistically significant results between
severity and CVR. Furthermore, this study was the first to evaluate the effectiveness of quantitative
CVR by examining the difference in the presence or absence of CVR in patients with acute
stroke.
Mindfulness meditation moderates the relationship between five prohibitions of Buddhism and subjective wellbeing
Authors: Phong Nguyen Van
Published: January 2022

Vietnam is a country of religious diversity, in which Buddhism has the most significant participation. In addition to practicing the Five Precepts, many Vietnamese people have registered for active mindfulness meditation classes recently. This fact has received significant attention from scientists to add to the evidence of previous studies. Enrich the research literature, so the study explores the role of mindfulness meditation practice as a moderator of the relationship between five precepts practice and subjective perception well-being of Vietnamese adults. This study was conducted through a cross-sectional survey using an intentional sampling technique (n=200). Multivariable linear regression analysis and moderator regression were applied to prove the hypotheses. Research results show a positive and meaningful relationship between practicing mindfulness meditation, practicing the five precepts and feeling subjective happiness. In particular, mindfulness meditation acts as a moderating variable between the practice of the five sexes and the subjective feeling of happiness.
COMMUNITY MOVEMENT IN INDEPENDENT VEGETABLE GROWING TO INCREASE HOUSEHOLD FOOD SECURITY DURING THE PANDEMIC
Authors: Yusida Ermita
Published: January 2022

The increase in the Covid-19 second wave in Indonesia has made the government implement a stricter policy to implement Community Activity Restrictions (PPKM). This activity aims to provide actionable solutions to maintain family food security through the community movement to grow vegetables. The method used in this activity is the Participatory Rural Appraisal (PRA) method which begins with FGD, counseling, and field practice. The activity implementer can become a facilitator and directly facilitate the community carrying out activities. The empowerment program was carried out in Kepuharjo Village, Malang Regency, with the main target being housewives. As a result of this activity, participants who attended the FGD and the facilitator decided to create a community movement in independent vegetable growing to stay productive during the pandemic. Community movement was conducted for two weeks, during which the activity implementation team provided all materials, planting media, and seeds. During the two weeks running, 53 housewives grew vegetables independently. Based on the evaluation results, this activity is very effective and efficient for household food fulfillment. Ninety-seven percent of homemakers say that they can increase their food needs with this movement, so they don't have to buy. Of course, it has an impact on saving household expenses. As many as 90 percent of homemakers do this activity and repeat it after harvest. So that the continuity of this activity can run well, besides decreasing spending, this activity can also improve health by producing healthier vegetables.
Kerentanan Sosial Ekonomi dan Resiliensi Keluarga Petani Miskin Selama Pandemi COVID-19: Kasus Dari Madura
Authors: Sabariman Hoiril , Susanti Anik
Published: January 2022

The Covid-19 pandemic, in addition its health impacts, also has a serious impact to people's socioeconomic vulnerabilities. Socio-economic vulnerabilities due to the Covid-19 pandemic forced people to adapt, one of which was a poor peasant family in rural Madura. This article presents the results of research focusing on the socio-economic vulnerability of poor peasant family as well as various efforts in dealing with the Covid-19 pandemic. Using descriptive qualitative approach and data collection method through participation observation, interviews, airy records, and documentation, this study revealed that the socioeconomic vulnerability of poor peasant family in Ponteh Village resulted from social restrictions so that the household income sector decreased. Though they have to adaptation meet the cost of household consumption, health threats in the Covid-19 pandemic. Adaptation strategy carried out by poor peasant family in rural areas is, first, building group solidarity according to values and norms that are strong, for example, mutual help in the form of basic needs. Second, every poor peasant family makes use of very strong family ties. Parental assistance as a source of supporting living is now a basic source used to make ends meet during pandemics. Third, poor peasant family in rural areas minimize household in spending and utilizing-social networks for business development. The contribution of this article is to provide views, efforts, accompanied by resilience in keeping the public from the threat of future pandemics.
Rusunawa dan Sandwich Generation: Resiliensi Masa Pandemi di Ruang Perkotaan
Authors: Rozalinna Genta Mahardika , Anwar Violetta Lovenika Nur
Published: January 2022

This study aims to analyze resilience from sandwich generation during the pandemics concerning the needs for living place (rusunawa) in city space East Java province. Rusunawa is a part of strategic plan from Flats directorate, ministry of public works and society housing in 2020-2024 which provides new houses for about 107-967 units through program flats building, special house and stimulant budget for constructing new self-subsistent house. Rusunawa is made especially for the people who has low income, and were built in around 18.380 unit. The method of taking data is using in-depth interviews on four members of sandwich generation which located in Malang, Probolinggo, Surabaya, and Sidoarjo also second data resources in form of empirical study report and government documents which related strategic plan rusunawa construction, the number of sandwich generation, also number of possession status of the rental house. The result is the narratives of experiences of sandwich generation for choosing a place to live also the interaction that happened among the sandwich generation in defining urban resilience. This debate happens in the context of understanding and embedding the word of tough and defense city in the thought of the sandwich generation. The economy factor happened dominantly to the sandwich generation for choosing the needs of a place to live other than the capacity of economy capacity, human, also disturbance during pandemic. All together think about the economy capacity which they had in a way of more to choose a place to stay with ste status of 'rental house' than possesed their own house without considering another capacities in the elements of city defense. This thing become contradictory in the middle of effort of the government which getting intense to the evaluation of indicator of the tough city for manifesting city defense.
Occupational Health and Safety Management System (SMK3) at the workshop of vocational high schools
Authors: Rizbudiani Adilla Desy , Jaedun Amat
Published: January 2022

This research aims to identify the planning implementation, idenfety Management System (SMK3) at the workshop of vocational high schools in the major of construction and property engineeringtify the implementation, and identify the evaluation of the implementation of the Occupational Health And Safety Management System (SMK3) at the workshop of Construction and Property Engineering Study Program, one of the Vocational High Schools in Central Java. This research is qualitative by using data collection techniques in interviews, observations, and documentation the validity of the data using source triangulation. Data analysis used descriptive qualitative. The results show that the workshop building at one of the Vocational High Schools in Central Java has been well planned in its implementation of OHS. The implementation of OHS is categorized as quite well implemented. The evaluation of the implementation of OHS is categorized as quite well done. Hence, the Occupational Health and Safety (OHS) management system at the Vocational High Schools needs to be improved. The school can collaborate with stakeholders to follow up on the management system of OHS.
Резонансная микроволновая спектроскопия полупроводников с микронным разрешением
Authors: Резник А.Н. , Востоков Н.В.
Published: January 2022

We have proposed and experimentally verified a local method of microwave resonant spectroscopy of semiconductors. The microwave circuit of the spectrometer based on the Cascade Microtech probe station is equipped with a coaxial resonator of special geometry. As result, the measurement accuracy of the previously developed volt-impedance spectroscopy method was greatly increased. A technique for spectrometer calibration and resonant measurements of the complex impedance of the probe-sample system has been developed. We have measured the impedance of test structures with Schottky contacts of 30 - 60 μm in diameter on a single-crystal GaAs wafer at several discrete frequencies in the range of 50 - 250 MHz. The nontrivial resistive properties of the structures are studied, which consist of the excess resistance that is 1–2 orders higher than the spreading resistance for the alternating current in the unperturbed region of the semiconductor. The discovered effect is presumably associated with the a.c. charge modulation on deep levels of the semiconductor. A model calculation of the impedance spectrum has been performed, which demonstrates a good agreement with the experimental spectra.
An mHealth App for Fibromyalgia-like Post–COVID-19 Syndrome: Protocol for the Analysis of User Experience and Clinical Data
Authors: Blanchard Marc , Backhaus Lars , Ming Azevedo Pedro , Hügle Thomas
Published: January 2022

Background

Post–COVID-19 syndrome, also referred as “long covid,” describes persisting symptoms after SARS-CoV-2 infection, including myalgia, fatigue, respiratory, or neurological symptoms. Objective symptoms are often lacking, thus resembling a fibromyalgia-like syndrome. Digital therapeutics have shown efficiency in similar chronic disorders such as fibromyalgia, offering specific disease monitoring and interventions such as cognitive behavioral therapy or physical and respiratory exercise guidance.

Objective

This protocol aims to study the requirements and features of a new mobile health (mHealth) app among patients with fibromyalgia-like post–COVID-19 syndrome in a clinical trial.

Methods

We created a web application prototype for the post–COVID-19 syndrome called “POCOS,” as a web-based rehabilitation tool aiming to improve clinical outcomes. Patients without organ damage or ongoing inflammation will be included in the study. App use will be assessed through user experience questionnaires, focus groups, and clinical data analysis. Subsequently, we will analyze cross-sectional and longitudinal clinical data.

Results

The developed mHealth app consists of a clinically adapted app interface with a simplified patient-reported outcome assessment, monitoring of medical interventions, and disease activity as well as web-based instructions for specific physical and respiratory exercises, stress reduction, and lifestyle instructions. The enrollment of participants is expected to be carried out in November 2021.

Conclusions

User experience plays an important role in digital therapeutics and needs to be clinically tested to allow further improvement. We here describe this process for a new app for the treatment of the fibromyalgia-like post–COVID-19 syndrome and discuss the relevance of the potential outcomes such as natural disease course and disease phenotypes.

International Registered Report Identifier (IRRID)

PRR1-10.2196/32193
Clinician Perspectives on Unmet Needs for Mobile Technology Among Hospitalists: Workflow Analysis Based on Semistructured Interviews (Preprint)
Authors: Savoy April , Saleem Jason J , Barker Barry C , Patel Himalaya , Kara Areeba
Published: January 2022

BACKGROUND

The hospitalist workday is cognitively demanding and dominated by activities away from patients’ bedsides. Although mobile technologies are offered as solutions, clinicians report lower expectations of mobile technology after actual use.

OBJECTIVE

The purpose of this study is to better understand opportunities for integrating mobile technology and apps into hospitalists’ workflows. We aim to identify difficult tasks and contextual factors that introduce inefficiencies and characterize hospitalists’ perspectives on mobile technology and apps.

METHODS

We conducted a workflow analysis based on semistructured interviews. At a Midwestern US medical center, we recruited physicians and nurse practitioners from hospitalist and inpatient teaching teams and internal medicine residents. Interviews focused on tasks perceived as frequent, redundant, and difficult. Additionally, participants were asked to describe opportunities for mobile technology interventions. We analyzed contributing factors, impacted workflows, and mobile app ideas.

RESULTS

Over 3 months, we interviewed 12 hospitalists. Participants collectively identified chart reviews, orders, and documentation as the most frequent, redundant, and difficult tasks. Based on those tasks, the intake, discharge, and rounding workflows were characterized as difficult and inefficient. The difficulty was associated with a lack of access to electronic health records at the bedside. Contributing factors for inefficiencies were poor usability and inconsistent availability of health information technology combined with organizational policies. Participants thought mobile apps designed to improve team communications would be most beneficial. Based on our analysis, mobile apps focused on data entry and presentation supporting specific tasks should also be prioritized.

CONCLUSIONS

Based on our results, there are prioritized opportunities for mobile technology to decrease difficulty and increase the efficiency of hospitalists’ workflows. Mobile technology and task-specific mobile apps with enhanced usability could decrease overreliance on hospitalists’ memory and fragmentation of clinical tasks across locations. This study informs the design and implementation processes of future health information technologies to improve continuity in hospital-based medicine.
A Mobile App to Increase Fruit and Vegetable Acceptance Among Finnish and Polish Preschoolers: Randomized Trial (Preprint)
Authors: Vepsäläinen Henna , Skaffari Essi , Wojtkowska Katarzyna , Barlińska Julia , Kinnunen Satu , Makkonen Riikka , Heikkilä Maria , Lehtovirta Mikko , Ray Carola , Suhonen Eira , Nevalainen Jaakko , Sajaniemi Nina , Erkkola Maijaliisa
Published: January 2022

BACKGROUND

Early childhood education and care (ECEC) centers are ideal venues for food education. As smartphones and tablets are becoming increasingly popular in ECEC centers, technology can be used to deliver such pedagogical content. Evidence suggests that video games can affect fruit and vegetable (FV) consumption among 9- to 12-year-old children, but studies among preschoolers are scarce.

OBJECTIVE

This paper describes the development of the Mole’s Veggie Adventures app and its effectiveness in increasing FV acceptance among Finnish and Polish preschoolers aged 3 to 6 years.

METHODS

A multiprofessional team created an app to be used in ECEC centers in groups of 3 to 10 children. The app aimed to increase vegetable acceptance, and it was built using elements that support the development of self-regulation and social skills. Altogether, 7 Finnish and 4 Polish ECEC centers participated in the study. Before randomization, parents reported background factors and their children’s willingness to taste different FVs. The ECEC professionals in the intervention arm were instructed to use the app at least once a week during the 3- to 4-week intervention period. The main outcomes in this unblinded, cluster-randomized study were FV acceptance and relative FV acceptance. The first was calculated as a sum variable describing the children’s willingness to taste 25 different FVs, the second as FV acceptance divided by the number of FVs served. We used analysis of covariance to compare the FV acceptance and relative FV acceptance scores between the intervention and control groups at follow-up.

RESULTS

A total of 221 children were included in the analysis. At follow-up, the intervention group (115/221, 52%) had higher FV acceptance scores (baseline adjusted difference of mean 7.22; 95% CI 1.41-13.03) than the control group (106/221, 48%). The intervention effect was parallel for relative FV acceptance scores (baseline adjusted difference of mean 0.28; 95% CI 0.05-0.52).

CONCLUSIONS

The Mole’s Veggie Adventures app has the potential to increase FV acceptance among preschoolers and can be a valuable tool in supporting food education in ECEC centers. Furthermore, the app can be feasibly incorporated into preschool routines in countries with different educational environments.

CLINICALTRIAL

ClinicalTrials.gov NCT05173311; https://tinyurl.com/4vfbh283
Frequent mask-wearing during the COVID-19 pandemic and acne: an infodemiology study from Google research trends (Preprint)
Authors: Salah Samir , Demessant-Flavigny Ann'Laure , Kerob Delphine
Published: January 2022

BACKGROUND

Researchers have been increasingly using the internet as a major source of health-related information and infodemiological methods have provided new approaches for studying the impact of coronavirus disease (COVID-19).

OBJECTIVE

To verify whether frequent mask-wearing during the COVID-19 pandemic was associated with an increase in acne search popularity.

METHODS

Data for mask-wearing were obtained from a NYT survey, with 250,000 responses between July 2 and 14, 2020, and from Google COVID-19 symptoms dataset for weekly acne and anxiety search popularity. All data in the study were presented in relation to US county levels. Each county was classified in the frequent mask-wearing group if the proportion of frequent users was above the third quartile. To make search trends comparable from one week to another and from one county to another, search trends were normalized on a relative 100-point scale, with the maximum value corresponding to the highest search popularity for a particular term in a specific week and a specific county. Other sources of data included the US census bureau datasets. Acne search popularity outcome was analyzed using a logistic regression, with COVID-19 incidence, metropolitan status of the county and anxiety search popularity as covariates, and mask-wearing status as the exposure variable. 2019 data, no mask-wearing, was used as a calibration control for acne search weight.

RESULTS

The final dataset consisted of 2893 counties with complete cases. Frequent mask-wearing was associated with an important increase in acne search popularity (OR=1.69; 95% CI (1.30-2.21); P<.001). A high relative incidence of COVID-19 was associated with an even greater acne search popularity (OR=8.42; 95% CI (6.48-10.96); P<.001).

CONCLUSIONS

Despite various biases, the use of infodemiology will keep increasing. Observational statistical methods need to be adapted to manage the large amounts of bias concerning web-based information more efficiently.
The Effect of Uncoupled Sleep and Dysfunctional Sleep Beliefs on Sleep Outcomes in Older Adults following Online Cognitive Behavioral Therapy for Insomnia: A Single-Group Non-randomized Trial (Preprint)
Authors: Kutzer Yvonne , Whitehead Lisa , Quigley Eimear , Fu Shih Ching , Stanley Mandy
Published: January 2022

BACKGROUND

The current Covid-19 pandemic has brought about a marked interest in sleep health, as well as an increased demand for telehealth services, such as online Cognitive Behavioral Therapy for insomnia (CBT-I). Older adults in particular report a high rate of sleep problems. Recent studies have suggested that dysfunctional sleep beliefs could contribute to the high rates of self-reported insomnia in this age group. In addition, older adults have an increased rate of uncoupled sleep, e.g. displaying an insomnia complaint in the absence of objectively measured poor sleep. It is essential to determine the prevalence of coupled and uncoupled sleep in older adults and to examine the efficacy of online CBT-I to improve sleep outcomes.

OBJECTIVE

This study aims to assess objective and subjective sleep quality and dysfunctional sleep beliefs in a sample of community-dwelling older adults aged 60-80 years with and without uncoupled sleep in Western Australia following digitally delivered CBT-I.

METHODS

Objective sleep was measured using wrist actigraphy, and subjective sleep quality via sleep diaries and the Pittsburgh Sleep Quality Index (PSQI). Dysfunctional sleep beliefs were assessed by the Dysfunctional Beliefs and Attitudes about Sleep scale (DBAS-16) prior to and following a four-week online CBT-I programme. Linear mixed model and generalised linear mixed model analyses were conducted to examine objective and subjective sleep onset latency, total sleep time, wake after sleep onset and number of awakenings as well as PSQI and DBAS16 scores, respectively.

RESULTS

62 participants (55 females; 88.7%) completed the study. CBT-I effectively reduced dysfunctional sleep beliefs and PSQI scores across all sleep classifications, even in good sleepers without a sleep complaint. Objective and self-reported changes in sleep parameters were mainly demonstrated in complaining poor sleepers. Complaining good sleepers reported a decrease in the number of subjective sleep awakenings only.

CONCLUSIONS

Online CBT-I was effective in improving the sleep outcomes of individuals who had both subjective and objective poor sleep. However, as the online CBT-I reduced dysfunctional sleep beliefs in all sleep groups, further examination of dysfunctional sleep beliefs and whether they mediate the outcomes of digital CBT-I in older adults will need to be conducted.

CLINICALTRIAL

Australian New Zealand Clinical Trials Registry (ANZCTR), ACTRN 12619001509156; http://www.anzctr.org.au/Trial/Registration/TrialReview.aspx?id=378451

INTERNATIONAL REGISTERED REPORT

RR2-32705
A Web-Based, Provider-Driven Mobile App to Enhance Patient Care Coordination Between Dialysis Facilities and Hospitals: Development and Pilot Implementation Study (Preprint)
Authors: Plantinga Laura C , Hoge Courtney , Vandenberg Ann E , James Kyle , Masud Tahsin , Khakharia Anjali , Gray Carol , Jaar Bernard G , Lea Janice P , O'Donnell Christopher M , Mutell Richard
Published: January 2022

BACKGROUND

We piloted a web-based, provider-driven mobile app (DialysisConnect) to fill the communication and care coordination gap between hospitals and dialysis facilities.

OBJECTIVE

This study aimed to describe the development and pilot implementation of DialysisConnect.

METHODS

DialysisConnect was developed iteratively with focus group and user testing feedback and was made available to 120 potential users at 1 hospital (hospitalists, advanced practice providers [APPs], and care coordinators) and 4 affiliated dialysis facilities (nephrologists, APPs, nurses and nurse managers, social workers, and administrative personnel) before the start of the pilot (November 1, 2020, to May 31, 2021). Midpilot and end-of-pilot web-based surveys of potential users were also conducted. Descriptive statistics were used to describe system use patterns, ratings of multiple satisfaction items (1=not at all; 3=to a great extent), and provider-selected motivators of and barriers to using DialysisConnect.

RESULTS

The pilot version of DialysisConnect included clinical information that was automatically uploaded from dialysis facilities, forms for entering critical admission and discharge information, and a direct communication channel. Although physicians comprised most of the potential users of DialysisConnect, APPs and dialysis nurses were the most active users. Activities were unevenly distributed; for example, 1 hospital-based APP recorded most of the admissions (280/309, 90.6%) among patients treated at the pilot dialysis facilities. End-of-pilot ratings of DialysisConnect were generally higher for users versus nonusers (eg, “I can see the potential value of DialysisConnect for my work with dialysis patients”: mean 2.8, SD 0.4, vs mean 2.3, SD 0.6; P=.02). Providers most commonly selected reduced time and energy spent gathering information as a motivator (11/26, 42%) and a lack of time to use the system as a barrier (8/26, 31%) at the end of the pilot.

CONCLUSIONS

This pilot study found that APPs and nurses were most likely to engage with the system. Survey participants generally viewed the system favorably while identifying substantial barriers to its use. These results inform how best to motivate providers to use this system and similar systems and inform future pragmatic research in care coordination among this and other populations.

CLINICALTRIAL
Revisitando la reproducción capitalista: equilibrio, redes y competencia intersectorial
Authors: Cajas Guijarro John
Published: January 2022

Este artículo revisita la reproducción capitalista desde un enfoque de equilibrio, redes y competencia. Así, luego de una revisión de literatura, se presenta un modelo de reproducción capitalista en tres etapas: 1) se expone cómo el equilibrio en los mercados de bienes limita la distribución sectorial del empleo; 2) se plantean redes monetarias que permiten reinterpretar la reproducción simple y ampliada usando cadenas de Markov, y 3) se incorpora el rol de la competencia intersectorial para explicar el surgimiento de la tasa media de ganancia a largo plazo y se exponen algunos aspectos que podrían dificultar ese surgimiento. Al final, se exponen las principales conclusiones y se plantean posibles discusiones futuras sobre la complejidad de la reproducción capitalista.
Isolation of Shewanella putrefaciens GRD 03 from Fish and Explication of Biofilm Adherence Potency on Different Substrates
Authors: Jayalekshmi Swathy Krishna , Krishna Arya Radhakrishnan , Antony Trisha Mary Pandipilly , Ramasamy Suganthi
Published: January 2022

Foodborne pathogens are the main threat and cause of food poisoning. The majority of food infections have been related to the biofilm formation of foodborne pathogens in the food industry. Shewanella putrefaciens (KX355803, GRD 03), a Gram-negative pathogen isolated from mackerel fish, was identified and recognized as a food spoilage bacterium and a strong biofilm producer. The adhesion or attachment ability of Shewanella putrefaciens was determined on steel, plastic, glass, PVC and wood. NB (Nutrient broth), LB (Luria-Bertani broth), TSB (Tryptic soy broth) and BHI (Brain heart infusion broth) were enriched with glucose and shows optimum for bacterial adhesion. In the microtiter plate method (MTP), the strong attachment was observed at 48 and 72 hours of incubation and significant differences were obtained at p < 0.05. As the incubation period increases, the OD value (Optical density) of samples also increase. Biofilm formation is the major cause cross-contamination, and shows resistance to certain disinfectants, which leads to environmental stress tolerance. This study suggested with optimum biofilm production of isolate from fish by using glucose enriched media on different substrates, also comparing different growth media provide a detailed idea about biofilm-forming ability at different incubation time intervals.