bluuebunny/crossref_metadata_2025 huggingface dataset:
JAK/STAT mediated insulin resistance in muscles is essential for effective immune response
Authors: McMullen Ellen , Strych Lukas , Chodakova Lenka , Krebs Amber , Dolezal Tomas
Published: April 2024

Background

The metabolically demanding nature of immune response requires nutrients to be preferentially directed towards the immune system at the expense of peripheral tissues. We study the mechanisms by which this metabolic reprograming occurs using the parasitoid infection ofDrosophilalarvae. To overcome such an immune challenge hemocytes differentiate into lamellocytes, which encapsulate and melanize the parasitoid egg. Hemocytes acquire the energy for this process by expressing JAK/STAT ligands upd2 and upd3, which activates JAK/STAT signaling in muscles and redirects carbohydrates away from muscles in favor of immune cells.

Methods

Immune response ofDrosophilalarvae was induced by parasitoid wasp infestation. Carbohydrate levels, larval locomotion and gene expression of key proteins were compared between control and infected animals. Efficacy of lamellocyte production and resistance to wasp infection was observed for RNAi and mutant animals.

Results

Absence of upd/JAK/STAT signaling leads to an impaired immune response and increased mortality. We demonstrate how JAK/STAT signaling in muscles leads to suppression of insulin signaling through activation of ImpL2, the inhibitor of Drosophila insulin like peptides.

Conclusions

Our findings reveal cross-talk between immune cells and muscles mediates a metabolic shift, redirecting carbohydrates towards immune cells. We emphasize the crucial function of muscles during immune response and show the benefits of insulin resistance as an adaptive mechanism that is necessary for survival.
Incidence and risk factors of proximal junctional kyphosis in adolescent idiopathic scoliosis after correction surgery: a meta-analysis and systematic review
Authors: Ji XingHua , Wei LinDong , Xing ZeJun , Duan YuChen
Published: April 2024

Aim

To analyze the risk factors of proximal junctional kyphosis (PJK) after correction surgery in patients with adolescent idiopathic scoliosis (AIS).

Methods

PubMed, Medline, Embase, Cochrane Library, Web of Science, CNKI, and EMCC databases were searched for retrospective studies utilizing all AIS patients with PJK after corrective surgery to collect preoperative, postoperative, and follow-up imaging parameters, including thoracic kyphosis (TK), lumbar lordosis (LL), proximal junctional angle (PJA), the sagittal vertical axis (SVA), pelvic incidence (PI), pelvic tilt (PT), pelvic incidence–lumbar lordosis (PI–LL), sacral slope (SS), rod contour angle (RCA) and upper instrumented vertebra (UIV).

Results

Nineteen retrospective studies were included in this meta-analysis, including 550 patients in the intervention group and 3456 patients in the control group. Overall, sex (OR 1.40, 95% CI (1.08, 1.83), P = 0.01), larger preoperative TK (WMD 6.82, 95% CI (5.48, 8.16), P < 0.00001), larger follow-up TK (WMD 8.96, 95% CI (5.62, 12.30), P < 0.00001), larger postoperative LL (WMD 2.31, 95% CI (0.91, 3.71), P = 0.001), larger follow-up LL (WMD 2.51, 95% CI (1.19, 3.84), P = 0.0002), great change in LL (WMD − 2.72, 95% CI (− 4.69, − 0.76), P = 0.006), larger postoperative PJA (WMD 4.94, 95% CI (3.62, 6.26), P < 0.00001), larger follow-up PJA (WMD 13.39, 95% CI (11.09, 15.69), P < 0.00001), larger postoperative PI–LL (WMD − 9.57, 95% CI (− 17.42, − 1.71), P = 0.02), larger follow-up PI–LL (WMD − 12.62, 95% CI (− 17.62, − 7.62), P < 0.00001), larger preoperative SVA (WMD 0.73, 95% CI (0.26, 1.19), P = 0.002), larger preoperative SS (WMD − 3.43, 95% CI (− 4.71, − 2.14), P < 0.00001), RCA (WMD 1.66, 95% CI (0.48, 2.84), P = 0.006) were identified as risk factors for PJK in patients with AIS. For patients with Lenke 5 AIS, larger preoperative TK (WMD 7.85, 95% CI (5.69, 10.00), P < 0.00001), larger postoperative TK (WMD 9.66, 95% CI (1.06, 18.26), P = 0.03, larger follow-up TK (WMD 11.92, 95% CI (6.99, 16.86), P < 0.00001, larger preoperative PJA (WMD 0.72, 95% CI (0.03, 1.41), P = 0.04, larger postoperative PJA (WMD 5.54, 95% CI (3.57, 7.52), P < 0.00001), larger follow-up PJA (WMD 12.42, 95% CI 9.24, 15.60), P < 0.00001, larger follow-up SVA (WMD 0.07, 95% CI (− 0.46, 0.60), P = 0.04), larger preoperative PT (WMD − 3.04, 95% CI (− 5.27, − 0.81), P = 0.008, larger follow-up PT (WMD − 3.69, 95% CI (− 6.66, − 0.72), P = 0.02) were identified as risk factors for PJK.

Conclusion

Following corrective surgery, 19% of AIS patients experienced PJK, with Lenke 5 contributing to 25%. Prior and post-op measurements play significant roles in predicting PJK occurrence; thus, meticulous, personalized preoperative planning is crucial. This includes considering individualized treatments based on the Lenke classification as our future evaluation standard.
Study protocol for a pragmatic randomised controlled trial of comparing enhanced acceptance and commitment therapy plus (+) added to usual aftercare versus usual aftercare only, in patients living with or beyond cancer: SUrvivors’ Rehabilitation Evaluation after CANcer (SURECAN) trial
Authors: Khan Imran , Taylor Stephanie J. C. , Robinson Clare , Moschopoulou Elisavet , McCrone Paul , Bourke Liam , Thaha Mohamed , Bhui Kamaldeep , Rosario Derek , Ridge Damien , Donovan Sheila , Korszun Ania , Little Paul , Morgan Adrienne , Quentin Olivier , Roylance Rebecca , White Peter , Chalder Trudie
Published: April 2024

Background

Two million people in the UK are living with or beyond cancer and a third of them report poor quality of life (QoL) due to problems such as fatigue, fear of cancer recurrence, and concerns about returning to work. We aimed to develop and evaluate an intervention based on acceptance and commitment therapy (ACT), suited to address the concerns of cancer survivors and in improving their QoL. We also recognise the importance of exercise and vocational activity on QoL and therefore will integrate options for physical activity and return to work/vocational support, thus ACT Plus (+).

Methods

We will conduct a multi-centre, pragmatic, theory driven, randomised controlled trial. We will assess whether ACT+ including usual aftercare (intervention) is more effective and cost-effective than usual aftercare alone (control). The primary outcome is QoL of participants living with or beyond cancer measured using the Functional Assessment of Cancer Therapy: General scale (FACT-G) at 52 weeks. We will recruit 344 participants identified from secondary care sites who have completed hospital-based treatment for cancer with curative intent, with low QoL (determined by the FACT-G) and randomise with an allocation ratio of 1:1 to the intervention or control. The intervention (ACT+) will be delivered by NHS Talking Therapies, specialist services, and cancer charities. The intervention consists of up to eight sessions at weekly or fortnightly intervals using different modalities of delivery to suit individual needs, i.e. face-to-face sessions, over the phone or skype.

Discussion

To date, there have been no robust trials reporting both clinical and cost-effectiveness of an ACT based intervention for people with low QoL after curative cancer treatment in the UK. We will provide high quality evidence of the effectiveness and cost-effectiveness of adding ACT+ to usual aftercare provided by the NHS. If shown to be effective and cost-effective then commissioners, providers and cancer charities will know how to improve QoL in cancer survivors and their families.

Trial registration

ISRCTN: ISRCTN67900293. Registered on 09 December 2019.

All items from the World Health Organization Trial Registration Data Set for this protocol can be found in Additional file 2 Table S1.
Factors associated with the Single Leg Squat test in female soccer players: a cross-sectional study
Authors: Ressman John , von Rosen Philip , Grooten Wilhelmus Johannes Andreas , Rasmussen-Barr Eva
Published: April 2024

Background

The Single Leg Squat (SLS) test is widely used in the clinical setting to examine and evaluate rehabilitation goals. It is simple to perform and is proposed to have biomechanical and neuromuscular similarities to athletic movements. The aim of the present study was to investigate whether demographics, previous injuries, and biomechanical and psychosocial factors are associated with the outcome of the SLS, assessed as a total score for all segments and as a separate knee segment in elite and sub-elite female soccer players.

Methods

We conducted a cross-sectional study involving 254 female soccer players (22 yrs; SD ± 4, height 1.69 m; SD ± 0.1, weight 64 kg; SD ± 6) from divisions 1–3 of the Swedish Soccer League. During the preseason, we assessed the participants using the SLS and tested their hip strength and ankle mobility. Demographics, previous injury, sleep quality, fear of movement, anxiety, and perceived stress were assessed with questionnaires. Logistic regression models were built to analyse the association between the outcome of the SLS and the independent variables for the dominant and non-dominant leg.

Results

Significantly more participants failed the SLS on the dominant leg compared with the non-dominant leg (p < 0.001). The outcome of the SLS associated with various biopsychosocial factors depending on if the dominant or non-dominant leg was tested. The total score associated with hip strength for the dominant (OR 0.99, 95% CI 0.98–0.99, p = 0.04) and the non-dominant leg (OR 0.99, 95% CI 0.97–0.99, p = 0.03). The knee segment associated with division level for the dominant (div 2; OR 2.34, 95% CI 1.01–5.12, p = 0.033. div 3; OR 3.07, 95% CI 1.61–5.85, p = 0.001) and non-dominant leg (div 2; OR 3.30, 95% CI 1.33-8.00, p = 0.01. div 3; OR 3.05, 95% CI 1.44–6.43, p = 0.003).

Conclusions

This study identified that leg dominance, division level, hip strength, and psychosocial factors were associated with the outcome of the SLS when assessed as a total score and as a separate knee segment. This indicates that clinicians need to understand that movement control is associated with factors from several domains. Whether these factors and, the results of the SLS are related to injury need to be studied prospectively.

Trial registration

Clinical Trials Gov, date of registration 2022-03-01. Clinical trials identifier: NCT05289284A.
Unmanned aerial vehicle-assisted wideband cognitive radio network based on DDQN-SAC
Authors: Yan Leibing , Cai Yiqing , Wei Hui
Published: April 2024

Cognitive radio (CR) systems have emerged as effective tools for improving spectrum efficiency and meeting the growing demands of communication. This study focuses on a flexible CR system based on opportunistic spectrum access technology, which enables secondary networks to efficiently utilize unoccupied spectrum resources for information transmission by actively sensing the spectrum utilization of primary networks. Specifically, we introduce unmanned aerial vehicles (UAV) technology into the CR system to further enhance its flexibility and adaptability, which enables the transmission efficiency of low-altitude UAV networks. In this CR system, UAVs are employed for more flexible spectrum management. The objective of this research is to maximize the average achievable rate of SUs by jointly optimizing the trajectories of secondary UAV, the trajectories of primary UAV, the beamforming of secondary UAV, subchannel allocation and sensing time. To achieve this goal, we employ deep reinforcement learning (DRL) algorithms to optimize these variables. Compared to traditional optimization algorithms, DRL algorithms not only have lower computational complexity but also achieve faster convergence. To address the mixed-action space problem, we propose a Dueling DQN-Soft Actor Critic algorithm. Simulation results demonstrate that the proposed approach in this paper significantly enhances the performance of the CR system compared to traditional baseline schemes. This is manifested in higher spectrum efficiency and data transmission rates, while minimizing interference with the primary network. This innovative research combines drone technology and DRL algorithms, bringing new opportunities and challenges to the future development of cognitive communication systems.
Post-surgical inflammatory neuropathy after anterior cruciate ligament repair: a case report
Authors: Sun Lisa Y. , Gray Andrew T. , Braehler Matthias R.
Published: April 2024

Background

Unanticipated symptoms of peripheral nerve damage following surgery are distressing to both the patient and their clinical team, including surgeons, anesthesiologists, and neurologists. The causes that are commonly considered for perioperative neuropathy can include surgical trauma, positioning-related injury, or injury related to a regional anesthetic technique. However, these cases often do not have a clear etiology and can occur without any apparent periprocedural anomalies. Postoperative inflammatory neuropathy is a more recently described, and potentially underrecognized cause of perioperative neuropathy which may improve with corticosteroid therapy. Therefore, it is an important etiology to consider early in the evaluation of perioperative neuropathy.

Case presentation

An otherwise healthy patient presented for left anterior cruciate ligament reconstruction. He underwent femoral and sciatic ultrasound-guided single-injection peripheral nerve blocks preoperatively, followed by a general anesthetic for the surgical procedure. He developed postoperative neuropathy in the sciatic distribution with both sensory and motor deficits. The patient received multi-disciplinary consultations, including neurology and pain management, and a broad differential diagnosis was considered. Based on neurological evaluation and imaging studies, a final diagnosis of post-surgical inflammatory neuropathy was made. The patient’s course improved with conservative management, but immunosuppressive treatment may have been considered for a more severe or worsening clinical course.

Conclusions

There are limited publications describing postoperative inflammatory neuropathy, and this case serves to illustrate a potentially under-recognized and multifactorial cause of postoperative neuropathy. Perioperative neuropathies are a complication that surgeons and anesthesiologists strive to avoid; however, prevention and treatment of this condition have been elusive. Increased reporting and investigation of postoperative inflammatory neuropathy as one cause for this complication will help to further our understanding of this potentially devastating complication.
Evaluation of ruminal methane and ammonia formation and microbiota composition as affected by supplements based on mixtures of tannins and essential oils using Rusitec
Authors: Foggi Giulia , Terranova Melissa , Daghio Matteo , Amelchanka Sergej L. , Conte Giuseppe , Ineichen Simon , Agnolucci Monica , Viti Carlo , Mantino Alberto , Buccioni Arianna , Kreuzer Michael , Mele Marcello
Published: April 2024

Background

Dietary supplements based on tannin extracts or essential oil compounds (EOC) have been repeatedly reported as a promising feeding strategy to reduce the environmental impact of ruminant husbandry. A previous batch culture screening of various supplements identified selected mixtures with an enhanced potential to mitigate ruminal methane and ammonia formation. Among these, Q-2 (named after quebracho extract and EOC blend 2, composed of carvacrol, thymol, and eugenol) and C-10 (chestnut extract and EOC blend 10, consisting of oregano and thyme essential oils and limonene) have been investigated in detail in the present study with the semi-continuous rumen simulation technique (Rusitec) in three independent runs. For this purpose, Q-2 and C-10, dosed according to the previous study, were compared with a non-supplemented diet (negative control, NC) and with one supplemented with the commercial EOC-based Agolin® Ruminant (positive control, PC).

Results

From d 5 to 10 of fermentation incubation liquid was collected and analysed for pH, ammonia, protozoa count, and gas composition. Feed residues were collected for the determination of ruminal degradability. On d 10, samples of incubation liquid were also characterised for bacterial, archaeal and fungal communities by high-throughput sequencing of 16S rRNA and 26S ribosomal large subunit gene amplicons. Regardless of the duration of the fermentation period, Q-2 and C-10 were similarly efficient as PC in mitigating either ammonia (−37% by Q-2, −34% by PC) or methane formation (−12% by C-10, −12% by PC). The PC was also responsible for lower feed degradability and bacterial and fungal richness, whereas Q-2 and C-10 effects, particularly on microbiome diversities, were limited compared to NC.

Conclusions

All additives showed the potential to mitigate methane or ammonia formation, or both, in vitro over a period of 10 d. However, several differences occurred between PC and Q-2/C-10, indicating different mechanisms of action. The pronounced defaunation caused by PC and its suggested consequences apparently determined at least part of the mitigant effects. Although the depressive effect on NDF degradability caused by Q-2 and C-10 might partially explain their mitigation properties, their mechanisms of action remain mostly to be elucidated.
Prioritizing susceptibility genes for the prognosis of male-pattern baldness with transcriptome-wide association study
Authors: Choi Eunyoung , Song Jaeseung , Lee Yubin , Jeong Yeonbin , Jang Wonhee
Published: April 2024

Background

Male-pattern baldness (MPB) is the most common cause of hair loss in men. It can be categorized into three types: type 2 (T2), type 3 (T3), and type 4 (T4), with type 1 (T1) being considered normal. Although various MPB-associated genetic variants have been suggested, a comprehensive study for linking these variants to gene expression regulation has not been performed to the best of our knowledge.

Results

In this study, we prioritized MPB-related tissue panels using tissue-specific enrichment analysis and utilized single-tissue panels from genotype-tissue expression version 8, as well as cross-tissue panels from context-specific genetics. Through a transcriptome-wide association study and colocalization analysis, we identified 52, 75, and 144 MPB associations for T2, T3, and T4, respectively. To assess the causality of MPB genes, we performed a conditional and joint analysis, which revealed 10, 11, and 54 putative causality genes for T2, T3, and T4, respectively. Finally, we conducted drug repositioning and identified potential drug candidates that are connected to MPB-associated genes.

Conclusions

Overall, through an integrative analysis of gene expression and genotype data, we have identified robust MPB susceptibility genes that may help uncover the underlying molecular mechanisms and the novel drug candidates that may alleviate MPB.
Intergenerational concern relates to constructive coping and emotional reactions to climate change via increased legacy concerns and environmental cognitive alternatives
Authors: Syropoulos Stylianos , Law Kyle Fiore , Mah Andrea , Young Liane
Published: April 2024

As the threat of climate change looms large, and we experience first-hand the impacts of rapid global warming, researchers and clinicians emphasize the need to better understand the impact of these changes on our mental health. Existing research suggests that coping with and emotional reactions to climate change can promote action to adapt to and mitigate the impacts of climate change and reduce its negative impacts to one’s mental health. In this pre-registered study (N = 771) we examined whether people who display extreme intergenerational concern would also constructively cope with climate change. Empirically-identified individuals showing high intergenerational concern reported more problem-focused and meaning-based coping, and less avoidant coping strategies with climate change. Further, even though they felt guilty, angry, sorrowful and isolated, these individuals also felt hopeful about the future. These effects were explained by increased concerns about one’s legacy and higher access to environmental cognitive alternatives. By instilling values that highlight intergenerational concern as a key priority, we could thus not only increase pro-climate action, but also help individuals actively and constructively cope with changes produced by climate change.
Συνεργατική μάθηση μέσω σημειολογικής ανατροφοδότησης στη διδασκαλία των αρχαίων ελληνικών
Authors: Λαζαροπούλου Δέσποινα
Published: April 2024

Η συνεργατική μάθηση βρίσκεται σε άνοδο γεγονός που συμβαδίζει με τις εξελίξεις στη σύγχρονη τεχνολογία. Ερευνητικά έργα που προάγουν τη διαπολιτισμική επικοινωνία μέσω ηλεκτρονικής συνεργασίας μεταξύ των μαθητών εξετάζονται τώρα υπό την προϋπόθεση ότι υπάρχει ένα κοινό εργαλείο αλληλεπίδρασης, μια κοινή γλώσσα. Αυτή η μελέτη, που διεξήχθη με την έγκριση του ελληνικού Υπουργείου Παιδείας, διαμορφώνει ένα εναλλακτικό εξ αποστάσεως, ψηφιακό και διαπολιτισμικά συνεργατικό περιβάλλον μάθησης, προάγοντας την ανταλλαγή γνώσης μέσα από μία διάταξη κατασκευασμένου λόγου (βασισμένο σε μία γλώσσα σημείων) σε συνάφεια με τη διδασκαλία των Αρχαίων Ελληνικών (ΑΕ). Οι συμμετέχοντες ολοκλήρωσαν ασκήσεις γραμματικής οι οποίες σε δεύτερο στάδιο διορθώθηκαν από τους ομότιμους καθρέφτες τους στην άλλη πλευρά της σήραγγας επικοινωνίας. Μια επινοημένη, σημειωτική γλώσσα χρησιμοποιήθηκε από τους συμμετέχοντες για να επικοινωνήσουν. Η βραχυπρόθεσμη και μακροπρόθεσμη επίδοση καταγράφηκε, το ίδιο και η αυτοπεποίθηση των υποκειμένων η οποία μετρήθηκε χρησιμοποιώντας μία ράβδο Vougiouklis και Vougiouklis (2008). Υποθέσαμε ότι αυτή η καινοτόμος προσέγγιση θα αύξανε όχι μόνο α) τις επιδόσεις των μαθητών (Lazaropoulou & Ypsilandis, 2019) αλλά και β) την αυτοπεποίθησή τους σχετικά με την ακρίβεια των απαντήσεών τους στο τεστ. Τα αποτελέσματα που αναλύθηκαν έδειξαν μια στατιστικά βελτιωμένη βαθμολογία στην επίδοση και την αυτοπεποίθηση των μαθητών στο post-test 1 (μετά από μία ώρα) και μια θετική τάση στο post-test 2 (μετά από μια εβδομάδα). Η μαθησιακή εμπειρία των συμμετεχόντων, ο προσωπικός χαρακτήρας αυτοπεποίθησής τους και η ποιότητα της παρεχόμενης ανατροφοδότησης που δοκιμάστηκαν ως ανεξάρτητες μεταβλητές, δεν αποδείχθηκε ότι αποτελούν περιοριστικοί παράγοντες στα αποτελέσματα των δοκιμών σε κανένα από τα δύο μετα-τεστ. Τα θετικά αποτελέσματα δείχνουν την πειραματική δοκιμή να είναι ευεργετική και να έχει θετικό αντίκτυπο σε όλους τους μαθητές (Έλληνες και Ιταλούς), ανεξάρτητα από α) τη μαθησιακή τους εμπειρία, β) την αρχική τους αυτοπεποίθηση στο αντικείμενο και γ) τον κίνδυνο να δοθεί λάθος ανατροφοδότηση. Τέλος, η επιλογή ενσωμάτωσης της τακτικής αλλαγής απάντησης αποδείχθηκε ωφέλιμη επιβεβαιώνοντας τις θετικές μεταβολές της συνεργασίας ως δείγμα γλωσσικής επίγνωσης.
A guide to selecting high-performing antibodies for Secreted frizzled-related protein 1 (sFRP-1) for use in Western Blot and immunoprecipitation
Authors: Ayoubi Riham , Southern Kathleen , Laflamme Carl ,   NeuroSGC/YCharOS collaborative group
Published: April 2024

Secreted frizzled-related protein 1 (sFRP-1) is a secreted protein, belonging to the secreted glycoprotein SFRP family. As a modulator of the Wnt/β-catenin signalling pathway, sFRP-1 has implications in human cancers and neurological diseases. If the community had access to well-characterized anti-sFRP-1 antibodies, the reproducibility of sFRP-1 research would be enhanced. In this study, we characterized 11 sFRP-1 commercial antibodies for Western Blot and immunoprecipitation, using a standardized experimental protocol based on comparing read-outs in knockout cell lines and isogenic parental controls. These studies are part of a larger, collaborative initiative seeking to address the antibody reproducibility issue by characterizing commercially available antibodies for human proteins and publishing the results openly as a resource for the scientific community. While use of antibodies and protocols vary between laboratories, we encourage readers to use this report as a guide to select the most appropriate antibodies for their specific needs.
Post kidney transplant hematologic abnormalities and association of post-transplant anemia with graft function
Authors: Laxminarayana Sindhura Lakshmi Koulmane , Jayaram Shreya , Swaminathan Shilna Muttickal , Attur Ravindra Prabhu , Rangaswamy Dharshan , Rao Indu Ramachandra , Bhojaraja Mohan V , Shenoy Srinivas Vinayak , Nagaraju Shankar Prasad
Published: April 2024

Background Haematological abnormalities following renal transplantation are frequently observed and have a significant effect on survival and graft outcomes. The pattern of haematological abnormalities varies globally. Few studies have been conducted in Asian countries. We aimed to evaluate the patterns of haematological abnormalities in post-transplant recipients in our center during the first year after post-renal transplant and the association of post-transplant anemia with graft function. Methods This single-center retrospective study was conducted on renal transplantation recipients between 2014 and 2019. The study included all patients who received kidney transplants from live/cadaveric donors and had follow-up data collected up to 12 months after the transplant. The outcome studied was the prevalence of haematological abnormalities and the association between post-transplant anemia (PTA) and graft function in post-transplant recipients. Results A total of 106 renal transplant recipients were included in the study. The prevalence of PTA was 98% in the first week, 75% at one month, 35% at three months, 32% at six months, and 27% at 12 months. The other cytopenia cases were leukopenia (43.4%), thrombocytopenia (33.2%), and pancytopenia (15.1%). Post-transplant erythrocytosis was observed in 17.9% of patients. 18 patients with severe PTA in the first week of transplant had significant allograft dysfunction (p=0.04). Patients with and without PTA had similar graft functions at six and 12 months (p=0.50). Conclusions Haematological abnormalities are common in renal transplant recipients. PTA is highly prevalent during the first week and improves over time. Other haematological abnormalities observed were leukopenia, thrombocytopenia, pancytopenia, and post-transplant erythrocytosis. Leucopenia was primarily drug-induced, and thrombocytopenia and pancytopenia were frequently caused by infections in our cohort. Additionally, severe PTA was significantly associated with graft dysfunction in the first week post-transplant, whereas similar graft function was observed at 6 and 12 months post-transplant, irrespective of the presence or absence of PTA.
Editorial
Authors: Dudek Dominika , Sobański Jerzy A. , Klasa Katarzyna
Published: April 2024

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„Wysiedleni” Doroty Combrzyńskiej-Nogali jako pojałtańska narracja migracyjna
Authors: Wądolny-Tatar, prof. UP Katarzyna
Published: April 2024

Artykuł jest próbą analizy zjawiska migracji z perspektywy dzieci. Autorkę interesuje wysiedleńczy aspekt tego zjawiska. Wskazuje na geograficzny oraz społeczny jego wymiar, analizując miejsce dziecka w przesiedleńczej rzeczywistości, posługując się przykładem Wysiedlonych Doroty Combrzyńskiej-Nogali, opowiadających historię przesiedlenia ludności z okolic Lwowa na Dolny Śląsk, a także innych pozycji uwzględniających los dziecka w wojenno-migracyjnej rzeczywistości.
Przybysz Shauna Tana – wizualna (o)powieść o emigracji i poszukiwaniu lepszego życia
Authors: Zarych Elżbieta
Published: April 2024

Powieść graficzna The Arrival (2006, pol. Przybysz, 2009) australijskiego rysownika Shauna Tana, rysunkowa opowieść o emigracji, zauroczyła czytelników w wielu krajach i została nagrodzona zarówno za artyzm, jak i uniwersalne i głębokie przesłanie. Sporą część nagród zdobyła jako książka dla dzieci, na które to zakwalifikowanie bez wątpienia wpłynęła dominacja obrazu kojarzonego z takim typem odbiorcy, choć lektura historii w obrazach łączących fotorealizm i surrealizm jest wymagająca i trudna nawet dla dorosłych. Również sposób przedstawienia, ujęcie tematu oraz podział tomu na dwie części, których głównymi bohaterami są najpierw ojciec (bezimienny przybysz), a potem jego córka, każą postrzegać tę publikację jako dwuadresową. Utwór dotykający aktualnych problemów wpisuje się w tematykę postkolonialną, w tym ważne dla niej kwestie kosmopolityzmu, obcości, tożsamości, przynależności, i w toczące się dyskusje na temat migracji. Książka bez słów opowiada historię mężczyzny, który w poszukiwaniu lepszego miejsca do życia dla swojej rodziny wyrusza do obcego kraju, gdzie wszystko jest dziwne i niezrozumiałe, do miejsca pełnego fantastycznych i surrealistycznych budowli, przedmiotów, zwierząt, niezrozumiałych znaków. To, czego doświadcza, było już wcześniej udziałem innych ludzi przybywających tu z różnych powodów, a w przyszłości będzie i kolejnych, dopóki ludzi z ich ojczystych krajów będą wyganiać wojna, głód i strach. W aklimatyzacji w nowym kraju ojcu pomagają przybyli tu wcześniej imigranci, potem zaś jego córka pomaga następnym przybyszom. Mimo indywidualizmu każdej z historii w dużej mierze są one uniwersalne. Podobna była też udziałem ojca Tana, przybyłego do Australii z Malezji. Rysownik w swojej rysunkowej powieści korzysta więc z wielu różnych źródeł, historii rodzinnych, biograficznych i literackich, opowiedzianych słowem, rysunkiem, zdjęciem, starając się, by czytelnik wczuł się w sytuację imigranta. Przybysz to także opowieść o czytaniu znaków tych znanych i tych początkowo niezrozumiałych: na poziomie fabuły odczytuje je przybyły do obcego kraju, w książce zaś czytelnik, składający z pozornie dziwnych i fantastycznych elementów opowieść dla małych i dużych o emigracji, ucieczce, podróży, samotności, pomocy i poszukiwaniu miejsca do życia.
Dzieci i młodzież w Australii na podstawie wypowiedzi zamieszczonych na portalu „Bumerang Polski”
Authors: Kansy Andrzej
Published: April 2024

Artykuł stanowi przegląd tematyki związanej zarówno z dziećmi, jak i młodzieżą na stronach australijskiego portalu skierowanego do Polonii w Australii. Badanie zostało przeprowadzone metodą analizy treści. Analizie poddano wszystkie teksty z lat 2010–2020.
Lechonia wiersze ulotne, czyli ludzie – sprawy – wydarzenia w nowojorskich czasach
Authors: Dorosz Beata
Published: April 2024

Artykuł prezentuje nieznane dotychczas cztery drobne utwory poetyckie Jana Lechonia powstałe na emigracji, odnalezione przez autorkę w archiwum poety w Polskim Instytucie Naukowym w Ameryce (Nowy Jork) i w zbiorach Harvard University (Cambridge), reprezentujące typ poezji ulotnej czy okolicznościowej. Jeden ma charakter utworu wyraźnie zaangażowanego politycznie i stanowił propagandowy głos w kampanii prezydenckiej w USA w 1948 r. Pozostałe albo są poświęcone znaczącej postaci w emigracyjnym życiu poety, albo stanowią rodzaj wierszowanej dedykacji. Analiza okoliczności ich powstania pozwala na przedstawienie części środowiska polskiej emigracji niepodległościowej w Nowym Jorku, z którym Lechoń utrzymywał bliskie kontakty towarzyskie.
Cztery dekady Polskiego Klubu Motorowego w Wielkiej Brytanii
Authors: Gondek Bartosz
Published: April 2024

Celem artykułu jest przypomnienie polonijnych automobilistów, działających w Polskim Klubie Motorowym w Wielkiej Brytanii. W wyniku kwerendy w zasobach archiwalnych polskich instytucji kulturalnych w Londynie oraz u osób prywatnych, udało się zebrać zachowane, pojedyncze relacje, oraz nieliczne zachowane, ale bardzo treściwe biuletyny informacyjne klubu, uzupełniając je prasą i książkami wydanymi w PRL a nawiązującymi do współpracy z PKM. W efekcie autorowi udało się stworzyć zarys działalności Polskiego Klubu Motorowego w Wielkiej Brytanii, będącego w zasadzie już całkowicie zapomnianym, a najbardziej wpływowym samochodowym związkiem sportowym Polaków mieszkających poza granicami kraju. Przypomniano też najważniejsze postacie, animujące polonijny ruch automobilowy na Wyspach Brytyjskich.
Between Warsaw and Jerusalem – Viola Wein
Authors: Karolina Famulska-Ciesielska Karolina
Published: April 2024

English version. Original issue: “Archiwum Emigracji” 2006, no. 1–2 (7–8)https://www.bu.umk.pl/Archiwum_Emigracji/gazeta/ae_7.pdf
"Czasy Wojny" by Ferdynand Goetel. An Attempt At Reading
Authors: Lutomierski Marcin
Published: April 2024

English version. Original issue: “Archiwum Emigracji” 2009, no. 2 (11)https://apcz.umk.pl/AE/article/view/AE.2009.053
The Activity of The Polish Institute of Arts and Sciences in 1942–1989
Authors: Nowożycki Bartosz
Published: April 2024

English version. Original issue: “Archiwum Emigracji” 2011, no. 1–2 (14–15)https://apcz.umk.pl/AE/article/view/AE.2011.017
Wspólna cela. Polacy, Niemcy i Ukraińcy w komunistycznych więzieniach w latach 1945–1956
Authors: Wolsza Tadeusz
Published: April 2024

Artykuł, przygotowany głównie na bazie memuarystyki, dotyczy wyłącznie pobytu w celi więziennej skazanych w powojennej Polsce Niemców i Ukraińców za zbrodnie popełnione w latach II wojny światowej oraz Polaków z pierwszej i drugiej konspiracji, których komuniści uznali za tzw. więźniów antypaństwowych. Rozważania obejmują lata 1945–1956.
Propaganda i pomoc dla Trzeciego Świata: działalność Polskiego Komitetu Solidarności z Narodami Azji, Afryki i Ameryki Łacińskiej, 1965–1990*
Authors: Gasztold Przemysław
Published: April 2024

Artykuł przedstawia działalność Polskiego Komitetu Solidarności z Narodami Azji, Afryki i Ameryki Łacińskiej w latach 1965–1990. Instytucja ta zajmowała się utrzymywaniem relacji z niektórymi państwami i ruchami narodowowyzwoleńczymi w Trzecim Świecie. Komitet udzielał im pomocy materialnej, stypendialnej, a także dbał o oprawę propagandową działań humanitarnych i politycznych PRL w Azji, Afryce i Ameryce Łacińskiej.
Instytucjonalizacja polskiej walki z rakiem. Między nauką i biopolityką
Authors: Szpak Ewelina
Published: April 2024

Celem prezentowanego artykułu jest próba pokazania na przykładzie onkologii zakresu przenikania się powojennej polskiej medycyny z polityką państwa oraz codziennością lekarzy.
Trudny teren. Podstawowa Organizacja Partyjna / Komitet Uczelniany PZPR Akademii Medycznej w Warszawie w świetle akt własnych
Authors: Rokicki Konrad
Published: April 2024

Artykuł przedstawia analizę treści dokumentacji archiwalnej uczelnianej organizacji PZPR w Akademii Medycznej. Celem badawczym było prześledzenie w tym specyficznym środowisku wpływu partii zarówno na pracowników uczelni, zwłaszcza kadrę naukową, jak i na jej władze od momentu powstania Akademii do ostatnich lat, gdy zachowała się dokumentacja Komitetu Uczelnianego, tj. do 1986 r.
The influence of Renaissance humanism on the legal ideas of towns-people in the Ruthenian lands of Crown Poland between the fifteenth and the first half of the seventeenth century
Authors: Hoshko Tetiana
Published: April 2024

Between the fifteenth and the mid-seventeenth century, Renaissance humanism influenced the legal ideas of educated strata in the Kingdom of Poland, including educated burghers. The article examines this process mainly on the example of towns in the Ruthenian lands of the Polish Crown. The result of this influence was several relatively new ideas reflected in legal treatises of this time, written mainly by lawyers from the townspeople, and in other sources: about the clarity and comprehensibility of law for ordinary people, the need to use the vernacular in legal texts, the unconditional supremacy of law, etc. The acquaintance of the townspeople with legal literature contributed to the spread of these ideas.
Profesorowie ekonomii i nauk pokrewnych na uniwersytetach II Rzeczypospolitej
Authors: Przeniosło Małgorzata , Przeniosło Marek
Published: April 2024

W artykule przedstawiono portret zbiorowy profesorów kierujących w okresie międzywojennym uniwersyteckimi katedrami ekonomii lub związanymi z ekonomią. Takie struktury utworzono na każdym z sześciu funkcjonujących wówczas uniwersytetów. Poszczególne fragmenty tekstu dotyczą miejsca urodzenia i pochodzenia społecznego profesorów; ich wykształcenia, drogi zawodowej i naukowej przed otrzymaniem katedry; aktywności naukowej (w tym szczególnie publikacyjnej); prowadzonych zajęć dydaktycznych; funkcji pełnionych na uczelni; aktywności politycznej i społecznej, także życia rodzinnego. Zarysowano również losy profesorów po 1939 r.
Granice oraz struktura terytorialna diecezji łuckiej od początku XIX wieku do 1939 roku
Authors: Kumor-Mielnik Joanna
Published: April 2024

W okresie od początku XIX w. do wybuchu drugiej wojny światowej diecezja łucka zmieniała swoje granice, a po dziewiętnastowiecznym zastoju w kształtowaniu struktur parafialnych, a nawet ich regresie spowodowanym kasatami parafii łacińskich, w dwudziestoleciu międzywojennym nastąpił jej dynamiczny rozwój. Procesowi temu towarzyszył intensywny wzrost budownictwa kościołów i kaplic. Dynamizm zachodzących zmian w strukturze diecezji łuckiej warunkowany był wieloma czynnikami i posiadał szeroki kontekst polityczny, społeczny i kulturowy.
Przykłady przeobrażeń przestrzennych wybranych łańcuchówek we współczesnych granicach województwa małopolskiego
Authors: Cepil Monika
Published: April 2024

Artykuł przedstawia wstępne wyniki badań na temat przemian przestrzennych wybranych łańcuchówek w województwie małopolskim. Celem było ukazanie przemian przestrzennych wsi o układach łańcuchowych od średniowiecza do czasów współczesnych. W pierwszej części przeanalizowano genezę łańcuchówek i określono ich cechy morfologiczne. W kolejnej części omówiono przemiany przestrzenne, które zaszły w badanych wsiach w okresie międzywojennym. Na koniec zaprezentowano współczesne formy łańcuchówek wraz z wyodrębnieniem ich przemian rozplanowania.
Analysis of the Early Childhood Education Curriculum from a Resilience Perspective
Authors: Fernández-Romero Margarita , Pardo Fabregat Francisco
Published: April 2024

As resilience refers to the human capacity to overcome challenging situations and quickly recover from them, fostering it from an early age in an educational context will enable children to be more efficient at both the cognitive and emotional levels. Therefore, the main objective of this study is to analyze the presence of resilience pillars in the current Spanish educational legislation, focusing on Early Childhood Education. In Spain, the new Education Law (LOMLOE) Organic Law 3/2020, amending Organic Law 2/2006, aims to enhance autonomy, initiative, and conflict resolution in children. In Royal Decree 95/2022 on Early Childhood Education, the three areas of knowledge (harmonious growth, discovery and exploration of the environment, and communication and representation of reality) are examined in relation to Steven J. Wolin and Sybil Wolin’s seven resilience pillars. In the second cycle of early childhood education, emphasis is placed on the development of specific competences for learning and doing, contributing to the comprehensive development of the child. Although the LOMLOE does not explicitly mention resilience, the curriculum reflects these resilience pillars—except for humor—highlighting the importance of understanding the individual characteristics and contexts of children. In summary, the promotion of resilience in early childhood education aligns with educational regulations in Spain, contributing to the comprehensive development of children and preparing them for future challenges.
Philosophical Counseling as a Form of Supporting Human Resilience
Authors: Tarchała Andrzej
Published: April 2024

The topic of this article is philosophical counseling as an effective tool to support human resilience. Philosophical counseling encourages individuals to become aware of their beliefs and values, develop critical thinking skills, and find essential meaning in life. However, it may not work for everyone and should be used as a complementary tool alongside other forms of support, such as humanistic psychotherapy. Undoubtedly, it is also important to consider systematic research on the potential benefits and limitations of philosophical counseling in supporting, for example, individual mental health, well-being, and broadly understood human resilience.
The law and professional considerations of confidentiality
Authors: Dowie Iwan
Published: April 2024

In this month's Policy column, Iwan Dowie explores the laws of confidentiality, which forms part of the legal obligation of every community nurse.
What influences specialist palliative care nurses working in a community setting to engage with research?
Authors: Hart Annette
Published: April 2024

This study explored clinical nurse specialists and their research role.

Aims:

The aim of this research was to understand what influences specialist palliative care nurses working in a community setting to engage with research.

Methods:

Qualitative research using interviews with community based clinical nurse specialists (CNS).

Findings:

A total of five themes were identified: research negativity and enthusiasm, clinical focus, audits, organisational support and keeping up to date.

Conclusion:

Except for audit activity, CNS do not view the research pillar as an integral part of their clinical role. Previous research education may not give the CNS the breadth of research skills that they require. The advance professional apprenticeship may resolve these education issues. Managers and organisations need to prioritise EBP skills; supporting nurses with both education and EBP mentors to develop these skills. Nurses require ongoing time to engage with research activity and use these skills to improve both their own clinical practice and those who use them as a research resource.
Nursery World visits…: Daycare St Martin's, Solihull
Authors: Weinstein Nicole
Published: April 2024

Nicole Weinstein visits a Birmingham day nursery on the site of an independent school to see loose parts play in action
We've explored…: music outdoors
Authors: Rawstrone Annette
Published: April 2024

The children at one setting in Scotland have access to an outdoor area with loose-parts musical ‘instruments’, and have even built their own stage, finds Annette Rawstrone
free movement: Without interference
Authors: Manning-Morton Julia , Tapping Rachel
Published: April 2024

The role of the adult in the Pikler approach to supporting young children's free movement is to pause before helping. By Julia Manning-Morton and Pikler UK's Rachel Tapping
team values: Talk it out
Authors: Fish Karen , Martin Lily
Published: April 2024

Karen Fish is nursery manager at Toddletown Nursery, Godalming, and Lily Martin is the deputy manager
First evidence of sea lice (Caligus fugu) infestation in captive map pufferfish in Thailand: Case report
Authors:   Phuket Marine Biological Center, Phuket 83000, Thailand, Banchongmanee Surapong , Jongjit Pathompong ,   Phuket Marine Biological Center, Phuket 83000, Thailand, Boonkasemsanti Araya ,   Phuket Marine Biological Center, Phuket 83000, Thailand, Kaewmong Patcharaporn ,   Phuket Marine Biological Center, Phuket 83000, Thailand, Patcharawatin Thanakrit ,   Department of Veterinary Medicine, Rajamangala University of technology tawan-ok, Chonburi 20110, Thailand, Chailangkarn Sasisophin ,   Department of Veterinary Biosciences and Veterinary Public Health, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand, Sripakdee Duanghatai ,   The Veterinary Diagnostic Center, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand, Pikulkaew Surachai ,   The Veterinary Diagnostic Center, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand,   Department of Food Animal Clinic, Faculty of Veterinary Medicine, Chiang Mai University, Chiang Mai 50100, Thailand, Nambooppha Boondarika ,   Phuket Marine Biological Center, Phuket 83000, Thailand
Published: April 2024

A captive map pufferfish from Phuket Sea region presented with abnormal posture of swimming and breathing. The veterinarian found ectoparasites on the puffer’s fins and skin. With the morphology under stereomicroscope, Caligus fugu was identified. With previously limited information, this report introduced the first evidence of C. fugu infestation in map pufferfish, Thailand. The puffer was successfully treated with 0.0075% hydrogen peroxide against adult C. fugu with negative for parasitic organisms. The importance of ectoparasites in aquaculture, especially in aquariums should be considered. In addition, we encourage further studies of genetic diversity and also seasonal occurrence of genus Caligus in Thailand to fulfill the understanding of the epidemiological factors of this pathogen.
The Use of Essential Oil-based Pharmaceutical Products to Control Cattle Ticks
Authors:   Faculty of Animal Science and Technology, Maejo University, Chiang Mai 50290, Thailand, Manwicha Apichart , Pattanawong Wiwat ,   Faculty of Animal Science and Technology, Maejo University, Chiang Mai 50290, Thailand, Vigad Nattha ,   Faculty of Animal Science and Technology, Maejo University, Chiang Mai 50290, Thailand, Chansakaow Sunee ,   Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200 Thailand, Tipduangta Pramote ,   Department of Pharmaceutical Sciences, Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200 Thailand, Chukiatsiri Kridda ,   Faculty of Animal Science and Technology, Maejo University, Chiang Mai 50290, Thailand
Published: April 2024

The purpose of this study was to compare the efficacy of six essential oils obtained from sour orange (Citrus aurantium L.), ginger (Zingiber officinale Roscoe), lemongrass (Cymbopogon citratus (DC.) Stapf.), litsea (Litsea cubeba (Lour.) Pers.), clove (Eugenia caryophyllata Thunb.) and curcumin (Curcuma longa Linn.) against cattle ticks. Two essential oils demonstrated the greatest significant efficiency and were chosen for further testing on the cattle skin. The results showed that the 8% lemongrass essential oil had the most significant inhibiting effect on the oviposition of engorged female cattle ticks, whereas ginger oil, curcumin oil, sour orange, litsea oil and clove oil, showed lesser effect respectively (p<0.05). There was a significant inverse relationship between lemongrass essential oil concentration and the tick’s oviposition index. It was observed that the higher the essential oil concentration (16%), the higher the mortality rate of the larva-stage ticks. Nevertheless, the 4, 8 and 16% of lemongrass essential oil concentrations were also effective against adult ticks, causing a 100% mortality rate. Lemongrass oil can reduce tick number from day 1 after spraying on cattle skin and the tick number was under control for at least 14 days, which is significantly different, comparing to the control group.
Immune evasion mechanisms of porcine epidemic diarrhea virus: A comprehensive review
Authors:   Virology and Vaccine Institute of the Philippines Program, Industrial Technology Development Institute, Department of Science and Technology, Bicutan, Taguig City, Philippines, Orosco Fredmoore L. ,   S&T Fellows Program, Department of Science and Technology, Bicutan, Taguig City, Philippines
Published: April 2024

Porcine epidemic diarrhea virus (PEDV) is a highly contagious coronavirus that causes significant economic losses to the swine industry worldwide. Understanding the host immune response to PEDV is crucial for developing effective control strategies. This review provides a comprehensive analysis of the host innate immune response against PEDV, with a focus on the modulation of interferon responses, regulation of apoptosis, and induction of endoplasmic reticulum (ER) stress. Several PEDV proteins have been identified as potent interferon antagonists that inhibit key components of the signaling pathway and suppress the production of type I and type III interferons. PEDV also induces apoptotic cell death through the activation of caspases, notably caspase-3 and caspase-8. Finally, PEDV infection induces ER stress, leading to activation of the unfolded protein response (UPR). Understanding these mechanisms provides valuable insights into PEDV pathogenesis and offers potential targets for therapeutic intervention. Future research should aim to address the remaining knowledge gaps to develop more effective strategies for controlling PEDV and other related coronaviruses.