bluuebunny/crossref_metadata_2025 huggingface dataset:
Tacrolimus: 10 years of successful clinical application
Authors: Bakulev A L , Bakulev A L
Published: February 2022

Tacrolimus (FK506) is the first drug from the new class of drugs - calcineurin inhibitors. It has a great potential and can change the current approaches to treatment of different dermatoses. Topical forms of Tacrolimus are activated due to the effect on T-lymphocyte signal transduction, and they also inhibit gene transcription. As a result, the T-cell response to antigens is alleviated. Percutaneous absorption of Tacrolimus in affection foci is higher than in healthy skin. Due to this a smaller amount of the drug is absorbed by the skin as long as the skin is healed. Systemic absorption of Tacrolimus is low in the course of treatment. The maximum clinical experience has been gained in the field of applying Tacrolimus for treatment of atopic dermatitis. In a number of clinical studies, 0.03-0.3% Tacrolimus ointment efficiently reduced the severity of symptoms and course of atopic dermatitis in adults and children. Moreover, topical treatment with Tacrolimus did not involve any substantial toxic effects. The patients most often complained of local irritations in the area where the ointment was applied, which were transient by nature and did not demand the drug withdrawal. Today Tacrolimus is a valuable and safer alternative to glucocorticosteroids for treatment of atopic dermatitis. It can also be used for treating other dermatoses, which demands additional all-round examination.
Combination treatment of psoriasis patients with kartalinointment and ehf therapy
Authors: Dmitruk V S , Dmitruk V S
Published: February 2022

The author assessed clinical efficacy of a combination treatment of psoriasis patients with EHF therapy and Kartalin ointment.
Clinical efficacy of combination treatment of psoriasis patients using the Kartalin ointment and EHF therapy was assessed in 153
patients suffering from mild to moderate psoriasis.
All of the subjects were divided into three groups. The first group comprised 30 people receiving conventional treatment (vitamins,
hyposensitization drugs and indifferent ointments) and the second group comprised 50 patients receiving conventional treatment
in a combination with EHF therapy. The third group comprised 73 patients receiving EHF therapy in a combination with Kartalin
ointment and conventional treatment.
It was established that extremely high frequency (EHF) radiation (4.7-5.1 mm) in a combination with Kartalin ointment had the most
evident effect on the clinical and morphological indices in psoriatic patients at the progression stage of the disease accompanied
by the decrease in PASI by 67.2%.
History of syphilis studies at the chair of skin and venerealdiseases, military medical academy, for its 140th anniversary
Authors: Samtsov A V , Sukharev A V , Ravodin R A , Samtsov A V , Sukharev A V , Ravodin R A
Published: February 2022

The article examines stages of development for one of the first Russian chairs of syphilology and assess the contribution made by
V.M. Tarnovsky, T.P. Pavlov, S.T. Pavlov and other employees to the development of syphilis studies.
Prevalence and clinical manifestations of cheilitis in children suffering from atopic dermatitis.
Authors: Toropova N P , Lepeshkova T S , Teplova S N
Published: February 2022

The authors present the results of studying clinical manifestations of cheilitis in 143 children suffering from atopic dermatitis. The severe stage of cheilitis was observed in 42.7% of children, the medium to severe stage - in 35.7%, the mild stage - in 21.6%. The authors revealed more frequent development of episodes of bronchial obstruction (55.3%) and recurrent respiratory diseases (69.2%) in such children. They also revealed defects of barrier, anticolonial and microbicide functions of the secretory immunity of the patients oral cavity. The administration of Imudon in the complex therapy produced a good therapeutic effect in 77.4% of children and reduced the frequency of development of acute respiratory diseases.
Revisited new data in the specialty: organizational and practical aspects
Authors: Kub anov a A A , Lesn aya I N , Chub S G
Published: February 2022

The authors analyzed the current normative and legal acts and methodical guidelines for rendering cosmetology aid to the population
of the Russian Federation. The article describes the content of major normative documents regulating the procedure for
introducing cosmetology as a new area of specialization.
Clinical and social problems of compliance in pediatric dermatology
Authors: Gorlanov I A , Mikirtichan G L , Zaslavskiy D V , Khaurova T V , Murashkin N N
Published: February 2022

The article is dedicated to the clinical and social analysis of problems concerning patient's and parent's compliance as well as investigation of the impact of various factors to treatment compliance in pediatric dermatology settings. For this purpose specially designed questionnaires for the participants of development of the treatment compliant behavior were used: physicians, pediatric patients of 13 to 18 years old suffering of chronic dermatoses, and their parents.
There are the following main predictors of low compliance among dermatological pediatric population: psychological problems of patients; an attitude of a patient and his/her family to the treatment of the disease; lack of confidence among patient in the provided therapy (only 20.2% of adolescents and 56.4% of their parents always accurately follow the prescribed treatment); incomplete awareness of patients and their parents regarding the disease (30.9% of parents noted that by their opinion they are adequately informed concerning the disease of their child); duration of therapy, which could be not always effective or legitimating expectations of patients; inter-individual relationship impairment within the triad of practitioner-child-parents. Taking into account the circumstances, professional and personal qualities of the attendant physician, the adherence by him/her the principles of medical ethics are of primary importance for better treatment compliance.
Mechanism of the biological effect of the tumor necrosis factor-аlpha at psoriasis
Authors: ZNAMENSKAYA L F , YEGOROVA YU YU , ZITNER S V
Published: February 2022

Among different cytokines, tumor necrosis factor-аlpha (tumor necrosis factor α, TNF-α) plays a special role in psoriatic immunopathogenesis. Data on this cytokine collected for the recent decades made it possible to create a number of biological drugs blocking TNF-α, which are successfully applied in clinical practice for treating medium to severe psoriasis and psoriatic arthritis. This review presents general information about the cytokine structure and its receptor apparatus, regulation mechanisms of TNF-α synthesis and ways of signal transmission as the basis needed to implement the biological effects of cytokine in the development of psoriatic skin affections.
Evaluation of the efficacy of introduction of a new medical technology fortreatment of chronic dermatoses based on the application of activated zincpyrithione
Authors: Kubanov A A , Petrovsky F I
Published: February 2022

The article presents the results of evaluating the efficacy of introduction of a medical technology known as application of Skin-Cap
(activated zinc pyrithione) in the therapy of chronic dermatoses in the course of a questionnaire survey of 303 dermatovenerologists
from 14 Russian cities. The authors revealed that the doctors awareness of this medical technology resulted in a considerable
growth of the percentage of patients who receive activated zinc pyrithione. The respondents mentioned the efficacy, safety
and simple use of the drug and algorithms of its administration disclosed in the medical technology. It was revealed that compliance
with the medical technology results in the lower frequency of visits to a doctor for evaluating the efficacy of treatment and
lower need in its correction. The respondents also noted an improvement in the patients attitude to their treatment.
AN ANALYSIS OF TEACHER’S STRATEGIES IN TEACHING ENGLISH
Authors: Mustika Ulfiatul , Wardah Wardah
Published: February 2022

This research was conducted to analyze what strategies the teachers have used in teaching English and what factors influence these strategies. This was a descriptive qualitative research for the English teacher of SMAN 1 Segedong. Data collection was carried out using interviews with an English teacher at the school. Data were analyzed using Familiarization and Organizing, Coding and Reducing, Interpreting and Representing. Based on research findings, there were five teaching strategies used by the teacher and three factor influence it. These strategies were discussion strategies, demonstration strategies, using electronic media as learning media, using games and providing reinforcement in the end teaching and learning process. There were three factors that influenced the teacher strategy in English at SMAN 1 Segedong. The first was the student factor which includes the background of the student's majors such as Science and Social Studies, and the student's condition in following the learning process. The second was the factor came from the teacher. This factor concerned the ability of teachers to use technology in supporting teaching strategy. Lastly, the facility includes how the learning tools are limited.
THE EFFECTIVENESS OF USING HANGMAN GAME TO STRENGTHEN YOUNG LEARNERS’ VOCABULARY
Authors: Munikasari Munikasari , Sudarsono Sudarsono , Riyanti Dwi
Published: February 2022

This research was conducted to find out the evidence of Hangman game in strengthening young learners vocabulary to the Year-7 students of SMP Negeri 4 Teluk Keramat-Sambas in Academic Year 2019/2020. This research was a pre-experimental research with one group pre-test and post-test design. The population of this research was all of Year-7 students with the total number of students were 114 students. The cluster random sampling was taken in this research as the technique of sampling, the participants consisted of 26 students. Referring to the research findings, it revealed that the technique could make students vocabulary increased significantly. It can be seen when the students learn vocabulary. Their attention and involvement indicated that the technique gave positive effect on students vocabulary mastery. They already understood the meaning and how to spell words correctly through Hangman game. The result of the research showed that Hangman game was effective to increase students vocabulary achievement. It was proven by the result of t-test computation is higher than t-critical value (9.24>2.060). This means that the Null Hypothesis (H0) which is the implementation of Hangman game does not affect the young learners vocabulary significantly was rejected, while the Alternative Hypothesis which is the implementation of Hangman game affect the young learners vocabulary significantly was accepted. The score of effect size was 1.8 and qualified as strong effect. To conclude, Hangman game enabled the students to recollect vocabulary easily and generate the students motivation in learning process. Thus, the writer suggested this technique to be implemented in teaching vocabulary.
Membrane Composition and Raf[CRD]-Membrane Attachment Are Driving Forces for K-Ras4B Dimer Stability
Authors: Cournia Zoe , Andreadelis Ioannis , Kiriakidi Sofia , Lamprakis Christos , Theodoropoulou Anastasia , Doerr Stefan , Chatzigoulas Alexios , Manchester John , Velez-Vega Camilo , Duca José
Published: February 2022

Ras proteins are membrane-anchored GTPases that regulate key cellular signaling networks. It has been recently shown that different anionic lipid types can affect the properties of Ras in terms of dimerization/clustering on the cell membrane. To understand the effects of anionic lipids on key spatiotemporal properties of dimeric K-Ras4B, we perform all-atom molecular dynamics simulations of the dimer K-Ras4B in the presence and absence of Raf[RBD/CRD] effectors on two model anionic lipid membranes: one containing 78% mol DOPC, 20% mol DOPS, and 2% mol PIP2 and another one with enhanced concentration of anionic lipids containing 50% mol DOPC, 40% mol DOPS, and 10% mol PIP2. Analysis of our results unveils the orientational space of dimeric K-Ras4B and shows that the stability of the dimer is enhanced on the membrane containing a high concentration of anionic lipids in the absence of Raf effectors. This enhanced stability is also observed in the presence of Raf[RBD/CRD] effectors although it is not influenced by the concentration of anionic lipids in the membrane, but rather on the ability of Raf[CRD] to anchor to the membrane. We generate dominant K-Ras4B conformations by Markov state modeling and yield the population of states according to the K-Ras4B orientation on the membrane. For the membrane containing anionic lipids, we observe correlations between the diffusion of K-Ras4B and PIP2 and anchoring of anionic lipids to the Raf[CRD] domain. We conclude that the presence of effectors with the Raf[CRD] domain anchoring on the membrane as well as the membrane composition both influence the conformational stability of the K-Ras4B dimer, enabling the preservation of crucial interface interactions.
Oxygen tolerant RAFT polymerisation initiated by living bacteria
Authors: Moloney Cara , Bennett Mechelle R , Catrambone Francesco , Turco Federico , Kovacs Katalin , Hill Phillip J , Alexander Cameron , Rawson Frankie J , Gurnani Pratik
Published: February 2022

Living organisms can synthesize a wide range of macromolecules from a small set of natural building blocks, yet there is potential for even greater materials diversity by exploiting biochemical processes to convert unnatural feedstocks into new abiotic polymers. Ultimately the synthesis of these polymers in situ might aid the coupling of organisms with synthetic matrices, and the generation of biohybrids or engineered living materials. The key step in biohybrid materials preparation is to harness the relevant biological pathways to produce synthetic polymers with predictable molar masses and defined architectures under ambient conditions. Accordingly, we report an aqueous, oxygen-tolerant RAFT polymerization platform based on a modified Fenton reaction which is initiated by Cupriavidus metallidurans CH34, a bacterial species with iron reducing capabilities. We show the synthesis of a range of water-soluble polymers under normoxic conditions, with control over the molar mass distribution, and also the production of block copolymer nanoparticles via polymerization-induced self-assembly. Finally, we highlight the benefits of using a bacterial initiation system by recycling the cells for multiple polymerisations. Overall, our method represents a highly versatile approach to producing well-defined polymeric materials within a hybrid natural-synthetic polymerization platform and in engineered living materials with properties beyond those of biotic macromolecules.
Islandzka reforma konstytucyjna w latach 2010–2020
Authors: Wszołek Anna
Published: February 2022

The Icelandic constitution was passed on June 17, 1944. Amendments were passed in 1959, 1984, 1991, 1995, and, 1999. None of them introduced any significant changes to the original document. The financial crisis of 2008 caused a decline in public trust of politicians and the existing political system in Icelandic society. Icelanders began to demand a review of the constitution. Constitutional reform began in 2010 and continues to this day.
Potret pelaksanaan pengembangan koleksi di perpustakaan IPB University
Authors: Himawan Deden , Kania Widiati
Published: February 2022

Penelitian ini bertujuan untuk mengetahui komponen-komponen dalam pengembangan koleksi di Perpustakaan IPB Univesity. Metode yang digunakan dalam penelitian ini adalah metode penelitian kualitatif dengan menggunakan pendekatan studi kasus eksploratoris. Hasil penelitian menunjukan bahwa pelaksanaan pengembangan koleksi sudah menggunakan pedoman tertulis yaitu kebijakan pengembangan koleksi yang direvisi setiap tiga tahun sekali. Komponen pelaksanaan pengembangan koleksi yang pertama adalah mengumpulkan dan menganalisa kebutuhan masyarakat pemustaka terutama sivitas akademika IPB, ke-dua menyusunan kebijakan seleksi yang teretuang dalam kebijakan pengembangan koleksi, ke-tiga melakukan seleksi yaitu pemilihan bahan perpustakaan berdasarkan hasil analisis kebutuhan, ke-empat melakukan proses pengadaan disertai dengan penerimaan semua bahan perpustakaan baik melalui pembelian, hadian maupun pertukaran, ke-lima adalah melakukan penyiangan koleksi yaitu mengeluarkan koleksi yang tidak relevan dan ke-enam adalah melaksanakan evaluasi, baik evaluasi koleksi maupun evaluasi keterpakaian koleksi.
Pelatihan Penulisan Resensi Karya Sastra Di SMK Giri Taruna 2 Bogor
Authors: Septiani Dwi , Maemunah Siti , A.I. Awla , A.A. Varatisha
Published: February 2022

Dalam pembelajaran di tingkat SMA/SMK, khususnya di kelas XI SMK, para siswa diharapkan dapat mengembangkan kemampuan menulis. Salah satu materi pembelajaran yang berhubungan dengan keterampilan menulis resensi karya sastra. Salah satu permasalahan yang ditemukan dalam pembelajaran Bahasa Indonesia terkait keterampilan menulis, khususnya penulisan resensi karya sastra. Menulis resensi karya sastra merupakan salah satu keterampilan yang menuntut keterampilan membaca kritis serta perbendaharaan kata yang luas sehingga dapat menarik pembaca dengan kata-kata yang bervariasi. Oleh karena itu, metode yang digunakan dalam pengabdian ini adalah berupa pelatihan menulis resensi karya sastra yang baik dan benar. Hasil kegiatan penelitian ini adalah melalui pelatihan menulis resensi karya sastra, siswa kelas XI di SMK Giri Taruna 2 Bogor termotivasi untuk membaca kritis karya sastra serta membuat karya tulis berupa resensi karya sastra. Pelatihan secara daring ini diikuti oleh 32 siswa dan 2 guru pendamping. Hasil kuesioner terkait evaluasi kualitas pelatihan penulisan resensi dari peserta pelatihan (siswa), yakni siswa mendapatkan dampak positif dalam pembelajaran bahasa Indonesia (4,88); siswa mampu menulis resensi karya sastra setelah mengikuti program pelatihan (4,81); dan  gaya instruktur pelatihan penulisan resensi karya sastra dalam penyampaian materi dan Suasana selama pelatihan berlangsung serius dan menyenangkan (4,75). Oleh karena itu, dapat disimpulkan bahwa pelatihan penulisan resensi karya sastra di SMK Giri Taruna 2 Bogor dinyatakan bermanfaat bagi para peserta (siswa kelas XI SMK).
الانقسام الفلسطيني 2006-2007
Authors: ALbeshtawi Assist.prof.Emad Reffat
Published: February 2022

تاريخ الاستلام:15/12/2020      تاريخ قبول النشر:29/12/2020       تاريخ النشر:31/12/2021
   This work is licensed under a Creative Commons Attribution 4.0 International License.
   تهدف الدراسة إلى استعراض الانقسام بين حركتي فتح وحماس بين عامي 2006م-2007م ,مستندة بشكل أساسي على الوثائق والتصريحات التي تم الإعلان عنها في وسائل الإعلام المختلفة، من خلال استعراض مجريات الأحداث عقب الانتخابات الفلسطينية عام 2006م، والتي أسفرت عن فوز حركة حماس ، مبينة مجريات الانقسام،وموقف كل من حركة فتح والسلطة الفلسطينية، وحركة حماس والفصائل الفلسطينية من أسباب الانقسام والمبادرات التي قدمت لإنهائه.
كما استعرضت الدراسة المواقف الدولية  والإسرائيلية من الانقسام، بالإضافة إلى مواقف الدول العربية منه،  والآثار التي ترتبت عليه على صعيد المشروع الوطني .
دور البرلمان العراقي في إقرار الموازنة الإتحادية بعد عام 2005
Authors: Abed Dr. Abeer Mohamed
Published: February 2022

تاريخ الاستلام:2/2/2021      تاريخ قبول النشر:6/4/2021       تاريخ النشر:31/12/2021
 This work is licensed under a Creative Commons Attribution 4.0 International License.
    يمثل اقرار الموازنة الاتحادية العامة في العراق من اهم اختصاصات السلطة التشريعية ، كونها تمثل احدى ادوات السياسية المالية والنقدية المهمة والتي تعتمد عليها الدولة في نموها الاقتصادي ، ومن ثم فأن عرقلة اقرار الموازنة الاتحادية بسبب المحاصصة الطائفية وغياب المصلحة الوطنية وبروز عمليات المساومة بين الاطراف السياسية التي تنتمي الى المناطقية والمذهبية ، فضلاً عن غياب الخطط والبرامج الاقتصادية نتيجة عدم الادراك وفهم طبيعة النظام السياسي المفترض تطبيقه في العراق وغياب المختصين من شأنه ان يؤدي الى تراجع سلبي بالجانب الاقتصادي والذي سيلقي بضلاله على الجانب الاجتماعي ومن ثم عدم استقرار النظام السياسي
الوسطية في السلوك السياسي الخارجي العماني (1970-2020)
Authors: Jasim Dr.Mohamed M.
Published: February 2022

تاريخ الاستلام:26/8/2020    تاريخ قبول النشر:8/9/2020      تاريخ النشر:31/12/2021
 This work is licensed under a Creative Commons Attribution 4.0 International License.
تضمن البحث الموسوم (الوسطية في السلوك السياسي الخارجي العماني 1970-2020) ، المقدمة ومبحثين ، إضافة إلى الخاتمة والتوصيات ، وقد تضمنت المقدمة فكرة عامة عن الموضوع ، وأهمية السلوك السياسي لدولة عمان خلال السنوات الخمسين الأخيرة إذ حاول البحث توضيح أسباب تبني سلطنة عمان السياسة الوسطية في سياستها الخارجية في عهد السلطان قابوس بن سعيد خلال المدة (1970-2020) بعد أن كانت سياستها الخارجية قبل عام 1970 تتسم بالعزلة عن المحيطين الإقليمي والدولي.
وقد تناول المبحث الأول التطورات السياسية الخارجية لدولة عمان ، خلال مدة حكم السلطان قابوس ، والذي عمل على تطبيق السلوك الوسطي في السياسة الخارجية ، وقد أتبع السلطان قابوس هذه السياسة لعدة أسباب ، في مقدمتها المحافظة على الأمن المجتمعي ، والاستمرار في تنفيذ برامج التنمية الاقتصادية، ولضمان نجاح هذه السياسة عمل السلطان قابوس لتصفير المشكلات مع الدول المجاورة ، مع الأخذ بنظر الاعتبار خصوصية الموقع الجغرافي لدولة عمان، وتطرق المبحث الثاني لموضوع الوسطية في التفاعلات السياسية الدولية ، باستعراض نماذج مختارة من السلوك الوسطي العماني، كالتفاعل العماني المؤثر في الأزمتين اليمنية والسورية، وكذلك الوساطة في مفاوضات الملف النووي الإيراني ، وقد حققت عمان فيها نجاحاً واضحاً ، وخاصة في حل أزمة البرنامج النووي الإيراني مع الدول الكبرى مما جعل السلطنة محط اهتمام واحترام الدول في المحيطين الإقليمي والدولي ، واختتم البحث بالخاتمة التي تضمنت الاستنتاجات والتوصيات
تأثير الفكر السياسي في حقوق الإنسان
Authors: Hamd A.t.mohammed hazm
Published: February 2022

تاريخ الاستلام:19/11/2020      تاريخ قبول النشر:10/1/2021       تاريخ النشر:31/12/2021
 This work is licensed under a Creative Commons Attribution 4.0 International License.
 تعد حقوق الإنسان من المفاهيم الأساسية في العصر الحديث والمعاصر، والفكر السياسي بوصفه أصل علم السياسة ومنبعه المعرفي تأثير في هذا العلم وفروعه وموضوعاته ومنها موضوعة حقوق الإنسان، إذ يُظهر البحث أن للفكر السياسي تأثير بالغ في حقوق الإنسان وبصورة شاملة، تأسيساً نظرياً وصياغة قانونية وتفسيراً ثقافياً، واقتضى العمل تقسيم البحث على ثلاثة مباحث، الأول: الجذور الفكرية لنشأة حقوق الإنسان، المبحث الثاني: تأثير الفكر السياسي في صياغة حقوق الإنسان، أما الثالث فجاء بعنوان: تأثير الفكر السياسي في تفسير حقوق الإنسان.
مفهوم الهوية في الفكر السياسي الغربي
Authors: Zaidan Asst.Tech.Saja Fattah
Published: February 2022

تاريخ الاستلام:8/10/2019      تاريخ قبول النشر:18/12/2019       تاريخ النشر:31/12/2021
 This work is licensed under a Creative Commons Attribution 4.0 International License.
يهتم البحث بمفهوم الهوية "المفهوم المجرد" بدون البحث في تصنيفات الهوية ولا الى المفاهيم التي تتناول انواعها وتصنيفاتها ، فقط المفهوم من ناحية الصورة المبدئية وكذلك اراء المفكرين حول اثبات وجود هوية ما وبما قرنوا هذا الاثبات ، حاولتُ في هذا البحث تحليل الافكار بصورة مبسطة ، فلاحظتُ انه في الفكر الغربي القديم يتناول المفكرين موضوع الهوية بأعتباره مرتبطاً بالذات الانسانية وبالوجود الذي يستند احيانا الى استعمال العقل واحياناً الى التفكير ، اما في العصور الوسطى نلاحظ ظهور الافكار الدينية التي بالتأكيد اثرت على الهويات وايضاً ظهور النزعات الجرمانية وتمايز الهوية الغربية ، اما في العصر الحديث والمعاصر تعددت الافكار والتفسيرات والآراء لنصل الى تعدد المفاهيم وبالتالي تعدد تبريرات تعدد انواع الهويات وقد لاحظنا انه بالإمكان  ابتكار انواع وتصنيفات جديدة للهوية تسهم في ظهور هويات جديدة ومبتكرة غير متعارف عليها حالياً وقد تصبح مألوفة عبر تقادم الاعتياد عليها بحثاً و انتماءً.
População LGBTQIA+
Authors: Varotto Bruna Luiza Roim , Massuda Mariana , Massuda Mariana , Nápole Rita de Cássia D'Ottaviano , Antequera Reynaldo
Published: February 2022

A população LGBTQIA+ ainda hoje sofre com o preconceito e estigma, o que pode dificultar o acesso aos serviços de saúde, aumentando a presença de morbidades neste grupo. O objetivo deste estudo foi realizar uma revisão de literatura com dois enfoques: o acesso aos serviços de saúde e odontológicos por pacientes LGBTQIA+ e quais as medidas educacionais que estão sendo implementadas com alunos dos cursos de Odontologia para diminuir o estigma sobre essa população e universalizar o acesso ao tratamento odontológico. Foi realizada uma revisão de literatura de estudos publicados entre 1995 e 2020 nas bases de dados PubMed, SciELO e Google Scholar. Foram selecionados 19 artigos, relatando principalmente aspectos das experiências de acesso à saúde bucal por pacientes LGBTQIA+; a experiência dos alunos de graduação em Odontologia com essa população; a inserção de atividades focadas na desmistificação desta população em cursos de graduação e o suporte fornecido pelas instituições de ensino aos alunos que se identificam como LGBTQIA+. Apenas dois estudos foram conduzidos no Brasil. Existem evidências provenientes principalmente de estudos internacionais para afirmar que a população LGBTQIA+ possui menor acesso aos serviços de saúde e há uma falta de preparo formal dos alunos de graduação para o atendimento destas pessoas.
Analisis Minat Belajar Matematika Siswa SMP Kelas VIII Pada Materi Persamaan Garis Lurus Berbantu Aplikasi Geogebra
Authors: Manalu Arpin Chronika Saida , Jumiati Yeti , Setiawan Wahyu
Published: February 2022

This research was conducted to analyze the interest in learning of junior high school students when conducting learning aided by the application of geogebra in the material of straight  line equatios. The method used in this study is a quasi experiment with percentage quantitative descriptive techniques. The population of this study is students at junior high school Pasundan 9 Bandung, by taking a sample  is 33 students of class VIII-C at junior high school Pasundan 9 Bandung. The instrument used in this study was a non-test instrument in the form of a questionnaire about students interest in learning after learning to use a geogebra application consisting of 20 statements. The result of this study are learning straight line equations in whose learning is assisted by the geogebra application get a positive response and can increase student interest in learning. Which can be seen from the average percentage obtained for each indicator 70,74% which means that most students already have an interest in learning mathematics learning mathematics learning assisted by geogebra applications.
Peningkatan Hasil Belajar Ilmu Pengetahuan Alam Peserta Didik Melalui Media Model Dengan Metode Inkuiri Di Kelas V SD Negeri 04 Payakumbuh Tahun 2019/2020
Authors: Rezkia Vivi
Published: February 2022

This study aims to improve student learning outcomes in class VC SD Negeri 04 Payakumbuh through a media model using the inquiry method. This type of research is classroom action research (CAR). The subjects of this study were all VC class students of SD Negeri 04 Payakumbuh in the 2019/2020 school year, totaling 35 people. The data obtained comes from student data, teachers, and documentation. The data collection procedure used observation instruments, field notes, tests, and documentation. The results showed that the media model with the inquiry method could improve student learning outcomes in science subjects for class VC SD Negeri 04 Payakumbuh. This is evidenced by the average value from the initial conditions of 62, in the first cycle it rose to 68.57, in the second cycle it became 76.28 and in the third cycle it reached 84.
“Captive by the Uncertainty”—Experiences with Anticipatory Guidance for People Living with Dementia and Their Caregivers at a Specialty Dementia Clinic
Authors: Shafir Adi , Ritchie Christine S. , Garrett Sarah B. , Bernstein Sideman Alissa , Naasan Georges , Merrilees Jennifer , Widera Eric , Flint Lynn , Harrison Krista L.
Published: February 2022

Background: After a diagnosis of Alzheimer’s disease and related disorders, people living with dementia (PWD) and caregivers wonder what disease trajectory to expect and how to plan for functional and cognitive decline. This qualitative study aimed to identify patient and caregiver experiences receiving anticipatory guidance about dementia from a specialty dementia clinic. Objective: To examine PWD and caregiver perspectives on receiving anticipatory guidance from a specialty dementia clinic. Methods: We conducted semi-structured interviews with PWD, and active and bereaved family caregivers, recruited from a specialty dementia clinic. Interviews were recorded, transcribed, and systematically summarized. Thematic analysis identified anticipatory guidance received from clinical or non-clinical sources and areas where respondents wanted additional guidance. Results: Of 40 participants, 9 were PWD, 16 were active caregivers, and 15 were bereaved caregivers. PWD had a mean age of 75 and were primarily male (n = 6/9); caregivers had a mean age of 67 and were primarily female (n = 21/31). Participants felt they received incomplete or “hesitant” guidance on prognosis and expected disease course via their clinicians and filled the gap with information they found via the internet, books, and support groups. They appreciated guidance on behavioral, safety, and communication issues from clinicians, but found more timely and advance guidance from other non-clinical sources. Guidance on legal and financial planning was primarily identified through non-clinical sources. Conclusion: PWD and caregivers want more information about expected disease course, prognosis, and help planning after diagnosis. Clinicians have an opportunity to improve anticipatory guidance communication and subsequent care provision.
Stage-Dependent Cerebral Blood Flow and Leukoaraiosis Couplings in Subcortical Ischemic Vascular Disease and Alzheimer’s Disease
Authors: Tu Min-Chien , Chung Hsiao-Wen , Hsu Yen-Hsuan , Yang Jir-Jei , Wu Wen-Chau
Published: February 2022

Background: Alzheimer’s disease (AD) and subcortical ischemic vascular disease (SIVD) have both been associated with white matter hyperintensities (WMHs) and altered cerebral blood flow (CBF) although the etiology of AD is still unclear. Objective: To test the hypothesis that CBF and WMHs have differential effects on cognition and that the relationship between CBF and WMHs changes with the subtypes and stages of dementia. Methods: Forty-two patients with SIVD, 50 patients with clinically-diagnosed AD, and 30 cognitively-normal subjects were included. Based on the Clinical Dementia Rating (CDR), the patients were dichotomized into early-stage (CDR = 0.5) and late-stage (CDR = 1 or 2) groups. CBF and WMH metrics were derived from magnetic resonance imaging and correlated with cognition. Results: Hierarchical linear regression revealed that CBF metrics had distinct contribution to global cognition, memory, and attention, whereas WMH metrics had distinct contribution to executive function (all p < 0.05). In SIVD, the WMHs in frontotemporal areas correlated with the CBF in bilateral thalami at the early stage; the correlation then became between the WMHs in basal ganglia and the CBF in frontotemporal areas at the late stage. A similar corticosubcortical coupling was observed in AD but involved fewer areas. Conclusion: A stage-dependent coupling between CBF and WMHs was identified in AD and SIVD, where the extent of cortical WMHs correlated with subcortical CBF for CDR = 0.5, whereas the extent of subcortical WMHs correlated with cortical CBF for CDR = 1–2.
White Matter Free Water Outperforms Cerebral Small Vessel Disease Total Score in Predicting Cognitive Decline in Persons with Mild Cognitive Impairment
Authors: Zhu Zili ,   for the Alzheimer’s Disease Neuroimaging Initiative, Zeng Qingze , Zhang Ruiting , Luo Xiao , Li Kaicheng , Xu Xiaopei , Zhang Minming , Yang Yunjun , Huang Peiyu
Published: February 2022

Background: Vascular pathology is an important partner of Alzheimer’s disease (AD). Both total cerebral small vessel disease (CSVD) score and white matter free water (FW) are useful markers that could reflect cerebral vascular injury. Objective: We aim to investigate the efficacy of these two metrics in predicting cognitive declines in patients with mild cognitive impairment (MCI). Methods: We enrolled 126 MCI subjects with 3D T1-weighted images, fluid-attenuated inversion recovery images, T2* images, diffusion tensor imaging images, cerebrospinal fluid biomarkers and neuropsychological tests from the Alzheimer’s Disease Neuroimaging Initiative database. The total CSVD score and FW values were calculated. Simple and multiple linear regression analyses were applied to explore the association between vascular and cognitive impairments. Linear mixed effect models were constructed to investigate the efficacy of total CSVD score and FW on predicting cognitive decline. Results: FW was associated with baseline cognition and could predict the decline of executive and language functions in MCI subjects, while no association was found between total CSVD score and cognitive declines. Conclusion: FW is a promising imaging marker for investigating the effect of CSVD on AD progression.
Design and performance analysis of an improved double-flux-concentrating coaxial magnetic gear
Authors: Wang Jungang , Qian Liqun , Xu Shuairui , Zhang Bin
Published: February 2022

Magnetic gear has the advantages of less noise and vibration in non-contact driving and has a broad application prospect. To improve the magnetic gear’s torque performance, an improved double-flux-concentrating coaxial magnetic gear (DFC-CMG) is proposed in this paper. The DFC-CMG adopts arc-shape inner permanent magnets (PMs) and spoke-type outer PMs, which are embedded in the rotor iron yoke and tangentially magnetized along the circumference. In addition, to reduce the amount of iron, the outer rotor yoke periphery of the proposed model is slotted. The finite element method (FEM) is used to simulate conventional and improved models, respectively. The air gap magnetic field and electromagnetic torque of the conventional model and the improved model are calculated, and the harmonic content of the inner and outer air gap magnetic density is analyzed. Simulation results show that the torque density of the improved model is 34.6% higher than that of the conventional model, and the output torque ripple of the outer rotor of the improved model is reduced by 0.58% compared to the conventional model. This paper can provide some references for high-performance magnetic gears.
Secure protocols for cumulative reward maximization in stochastic multi-armed bandits
Authors: Ciucanu Radu , Lafourcade Pascal , Lombard-Platet Marius , Soare Marta
Published: February 2022

We consider the problem of cumulative reward maximization in multi-armed bandits. We address the security concerns that occur when data and computations are outsourced to an honest-but-curious cloud i.e., that executes tasks dutifully, but tries to gain as much information as possible. We consider situations where data used in bandit algorithms is sensitive and has to be protected e.g., commercial or personal data. We rely on cryptographic schemes and propose [Formula: see text], a secure multi-party protocol based on the UCB algorithm. We prove that [Formula: see text] computes the same cumulative reward as UCB while satisfying desirable security properties. In particular, cloud nodes cannot learn the cumulative reward or the sum of rewards for more than one arm. Moreover, by analyzing messages exchanged among cloud nodes, an external observer cannot learn the cumulative reward or the sum of rewards produced by some arm. We show that the overhead due to cryptographic primitives is linear in the size of the input. Our implementation confirms the linear-time behavior and the practical feasibility of our protocol, on both synthetic and real-world data.
Review of ensemble classification over data streams based on supervised and semi-supervised
Authors: Han Meng , Li Xiaojuan , Wang Le , Zhang Ni , Cheng Haodong
Published: February 2022

Most data stream ensemble classification algorithms use supervised learning. This method needs to use a large number of labeled data to train the classifier, and the cost of obtaining labeled data is very high. Therefore, the semi supervised learning algorithm using labeled data and unlabeled data to train the classifier becomes more and more popular. This article is the first to review data stream ensemble classification methods from the perspectives of supervised learning and semi-supervised learning. Firstly, basic classifiers such as decision trees, neural networks, and support vector machines are introduced from the perspective of supervised learning and semi-supervised learning. Secondly, the key technologies in data stream ensemble classification are explained from the two aspects of incremental and online. Finally, the majority voting and weight voting are explained in the ensemble strategies. The different ensemble methods are summarized and the classic algorithms are quantitatively analyzed. Further research directions are given, including the handling of concept drift under supervised and semi-supervised learning, the study of homogeneous ensemble and heterogeneous ensemble, and the classification of data stream ensemble under unsupervised learning.
RETRACTED: Segmentation of human spermatozoa using improved Havrda-Chavrat entropy-based thresholding method
Authors: Prabaharan L. , Raghunathan A.
Published: February 2022

This article has been retracted. A retraction notice can be found at https://doi.org/10.3233/JIFS-219433.
Development of Contractures in DMD in Relation to MRI-Determined Muscle Quality and Ambulatory Function
Authors: Willcocks Rebecca J. , Barnard Alison M. , Wortman Ryan J. , Senesac Claudia R. , Lott Donovan J. , Harrington Ann T. , Zilke Kirsten L. , Forbes Sean C. , Rooney William D. , Wang Dah-Jyuu , Finanger Erika L. , Tennekoon Gihan I. , Daniels Michael J. , Triplett William T. , Walter Glenn A. , Vandenborne Krista
Published: February 2022

Background: Joint contractures are common in boys and men with Duchenne muscular dystrophy (DMD), and management of contractures is an important part of care. The optimal methods to prevent and treat contractures are controversial, and the natural history of contracture development is understudied in glucocorticoid treated individuals at joints beyond the ankle. Objective: To describe the development of contractures over time in a large cohort of individuals with DMD in relation to ambulatory ability, functional performance, and muscle quality measured using magnetic resonance imaging (MRI) and spectroscopy (MRS). Methods: In this longitudinal study, range of motion (ROM) was measured annually at the hip, knee, and ankle, and at the elbow, forearm, and wrist at a subset of visits. Ambulatory function (10 meter walk/run and 6 minute walk test) and MR-determined muscle quality (transverse relaxation time (T2) and fat fraction) were measured at each visit. Results: In 178 boys with DMD, contracture prevalence and severity increased with age. Among ambulatory participants, more severe contractures (defined as greater loss of ROM) were significantly associated with worse ambulatory function, and across all participants, more severe contractures significantly associated with higher MRI T2 or MRS FF (ρ: 0.40–0.61 in the lower extremity; 0.20–0.47 in the upper extremity). Agonist/antagonist differences in MRI T2 were not strong predictors of ROM. Conclusions: Contracture severity increases with disease progression (increasing age and muscle involvement and decreasing functional ability), but is only moderately predicted by muscle fatty infiltration and MRI T2, suggesting that other changes in the muscle, tendon, or joint contribute meaningfully to contracture formation in DMD.
Early-Onset Parkinson’s Disease and Brain Iron Accumulation Caused by a Novel Homozygous DJ-1 Mutation
Authors: Lin Rong-Rong , Tao Qing-Qing , Wu Zhi-Ying
Published: February 2022

DJ-1 mutations are rare causes of autosomal recessive early-onset Parkinson’s disease (AR-EOPD) and relatively rarely reported in the Chinese population. Here, we used the whole-exome sequencing and Sanger sequencing to investigate DJ-1 mutations in the Chinese population and confirmed the pathogenicity of the mutation using primary fibroblasts established from skin biopsies. We identified a novel homozygous mutation (c.390delA, p.D131Tfs*3) in DJ-1 in a consanguineous Chinese family. The proband in this family had parkinsonism at the age of 22. His brain MRI indicated brain iron accumulation in the basal ganglia and cerebellum. The novel mutation caused DJ-1 protein deficiency, led to mitochondrial dysfunction, inhibited cell proliferation, and anti-oxidant defense.
Chemical co-precipitation synthesis of manganese ferrite (MnFe2O4) nanoparticles as a magnetic adsorbent of lead
Authors: Shahidizandi Shima , Mohammadi-Manesh Hossein , Loghavi Mohammad Mohsen , Hakimi Mohsen
Published: February 2022

Herein, MnFe2O4 binary oxides, including various percentages of Fe3O4 were synthesized using the chemical co-precipitation method. In order to determine the physicochemical properties, Fourier transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), and energy-dispersive X-ray spectroscopy (SEM-EDX) analyses were used. Adsorbent dosage, pH of the solution, contact time, and adsorbate concentration were optimized during the adsorption process. It was found that the Langmuir isotherm model is the best kinetic model for adsorption. Finally, the mean adsorption energy, reproducibility, and spontaneity of the adsorbent were also estimated, which showed that the physical adsorption mechanism is dominant.
Characterization and optimization of ZnS thin film properties synthesis via chemical bath deposition method for solar cell buffer layer
Authors: Ahmed Z. , Rahman Tareq , Hussain K.M.A. , Khatun M.T. , Chowdhury M.S.S. , Faruqe T. , Toma F.T.Z. , Ahmed Y. , Khan M.N.I. , Alam M.M.
Published: February 2022

Zinc Sulphide is one of most studied semiconductor with wide band gap (3.5–3.9 eV) versatile material due to its physical and chemical properties. ZnS is a non-toxic material and a suitable candidate to be a buffer layer for heterojunction solar cells. In this study, Zinc Sulphide (ZnS) thin films were deposited by chemical bath deposition technique using Zinc Acetate Dihydrate [Zn (CH3COO)2. 2H2O] and Thiourea [CH4N2S]. The ZnS thin films samples were characterized by UV-Vis NIR Spectroscopy, X-ray diffraction (XRD), Scanning Electron Microscopy (SEM), Energy Dispersive Spectroscopy (EDX), Fourier-Transform Infrared Spectroscopy (FTIR) and Thin-Film Measurement Instrument. FTIR spectra confirmed the presence of ZnS bond in the crystalline thin film. XRD data confirmed the cubic structure of the deposited thin film only when the amount of Thiourea was increased and the complexing agent Hydrazine Hydrate was replaced with Tri-Sodium Citrate. Crystallite size and strain were estimated using Debye-Scherrer model and Williamson-Hall model and lattice constant was estimated using Nelson-Riley plot. Otherwise, XRD showed the amorphous phase. UV-Vis data confirmed ZnS thin films as enough transmittive and it showed higher bandgap. Thin-Film Measurement Instrument was used to measure the thickness of the ZnS thin films. Synthesized ZnS thin films exhibited promising characteristics for using as the buffer layer of the heterojunction solar cells. Highlights • ZnS thin films were prepared successfully by simple, low cost and environment friendly chemical bath deposition method. • XRD measurement confirmed both Amorphous and Crystalline phase of ZnS thin films. • By changing the precursor only can be achieved crystalline phase from amorphous phase of ZnS thin film. • The amount of precursor and deposition conditions can be optimized to produce crystalline ZnS thin film.
The analysis of security and privacy risks in smart education environments
Authors: Kamenskih Anton
Published: February 2022

The contemporary smart educational environment uses different information technologies like social networks, virtual laboratories, augmented reality, artificial intelligence, big data, and so on. Each of these technologies has its security and privacy threats profile, but their integration in one system can lead to completely new challenges. The article analyses the technological development of smart educational environments from the point of view of their security and privacy issues. Any technological or legislative security control could be broken as the result of one mistake caused by human factors. People with different levels of competence are interacting every day with each other in educational environments. The risks of personal data leaking or hacking of educational services should be minimized during this interaction. Therefore, not only the key technologies that form the architecture of the educational environment but also the main points of interaction between the users and the education environment should be taken into account in the analysis. The article provides a basic analysis of security and privacy risks for smart education environments. As the result, the analysis identifies key information security technologies development of which is necessary for the sustainable development of a smart educational environment as part of a smart city.
Taxonomy enrichment with text and graph vector representations
Authors: Nikishina Irina , Tikhomirov Mikhail , Logacheva Varvara , Nazarov Yuriy , Panchenko Alexander , Loukachevitch Natalia
Published: February 2022

Knowledge graphs such as DBpedia, Freebase or Wikidata always contain a taxonomic backbone that allows the arrangement and structuring of various concepts in accordance with hypo-hypernym (“class-subclass”) relationship. With the rapid growth of lexical resources for specific domains, the problem of automatic extension of the existing knowledge bases with new words is becoming more and more widespread. In this paper, we address the problem of taxonomy enrichment which aims at adding new words to the existing taxonomy. We present a new method which allows achieving high results on this task with little effort. It uses the resources which exist for the majority of languages, making the method universal. We extend our method by incorporating deep representations of graph structures like node2vec, Poincaré embeddings, GCN etc. that have recently demonstrated promising results on various NLP tasks. Furthermore, combining these representations with word embeddings allows us to beat the state of the art. We conduct a comprehensive study of the existing approaches to taxonomy enrichment based on word and graph vector representations and their fusion approaches. We also explore the ways of using deep learning architectures to extend taxonomic backbones of knowledge graphs. We create a number of datasets for taxonomy extension for English and Russian. We achieve state-of-the-art results across different datasets and provide an in-depth error analysis of mistakes.