bluuebunny/crossref_metadata_2025 huggingface dataset:
Small bowel adenocarcinoma incarcerated within an inguinal hernia
Authors: Kawai Hironari , Haruki Koichiro , Takada Naoki , Iino Toshio , Ikegami Masahiro , Yanaga Katsuhiko
Published: December 2019

Background

Small bowel adenocarcinomas are rare malignant tumors that account for less than 2% of gastrointestinal malignancies. In addition, tumor incarceration in an inguinal hernia is also rare entity. We herein report a first case of small bowel adenocarcinoma incarcerated within an inguinal hernia.

Case presentation

A 75-year-old man with asymptomatic anemia (hemoglobin, 8.6 g/dl) had a checkup at our hospital. Colonoscopy revealed bleeding through the ileocecal valve and an annular stricture by a tumor in the ileum. Endoscopic biopsy revealed a well-differentiated adenocarcinoma of the small bowel. Enhanced computed tomography showed a hypervascular solid tumor incarcerated within a right inguinal hernia. With a diagnosis of small bowel adenocarcinoma incarcerated within a right inguinal hernia, the patient underwent elective laparotomy with midline excision. The small bowel tumor, located at 30 cm from the terminal ileum, was incarcerated within a right inguinal hernia, and the small bowel was adherent to the hernia sac. A 24-cm segment of the distal ileum and regional lymph nodes were resected. The hernia sac was ligated, and the bottom of the hernia sac was resected. The hernia orifice was closed by tissue repair technique via a standard oblique incision in the right inguinal region. Postoperatively, the patient remains well with no evidence of tumor or hernia recurrence as of 1 year after operation.

Conclusions

We reported to our knowledge the first case of small bowel adenocarcinoma incarcerated within an inguinal hernia.
Diagnosis and Treatment of Keloids and Hypertrophic Scars—Japan Scar Workshop Consensus Document 2018
Authors: Ogawa Rei , Akita Sadanori , Akaishi Satoshi , Aramaki-Hattori Noriko , Dohi Teruyuki , Hayashi Toshihiko , Kishi Kazuo , Kono Taro , Matsumura Hajime , Muneuchi Gan , Murao Naoki , Nagao Munetomo , Okabe Keisuke , Shimizu Fumiaki , Tosa Mamiko , Tosa Yasuyoshi , Yamawaki Satoko , Ansai Shinichi , Inazu Norihisa , Kamo Toshiko , Kazki Reiko , Kuribayashi Shigehiko
Published: December 2019

There has been a long-standing need for guidelines on the diagnosis and treatment of keloids and hypertrophic scars that are based on an understanding of the pathomechanisms that underlie these skin fibrotic diseases. This is particularly true for clinicians who deal with Asian and African patients because these ethnicities are highly prone to these diseases. By contrast, Caucasians are less likely to develop keloids and hypertrophic scars, and if they do, the scars tend not to be severe. This ethnic disparity also means that countries vary in terms of their differential diagnostic algorithms. The lack of clear treatment guidelines also means that primary care physicians are currently applying a hotchpotch of treatments, with uneven outcomes. To overcome these issues, the Japan Scar Workshop (JSW) has created a tool that allows clinicians to objectively diagnose and distinguish between keloids, hypertrophic scars, and mature scars. This tool is called the JSW Scar Scale (JSS) and it involves scoring the risk factors of the individual patients and the affected areas. The tool is simple and easy to use. As a result, even physicians who are not accustomed to keloids and hypertrophic scars can easily diagnose them and judge their severity. The JSW has also established a committee that, in cooperation with outside experts in various fields, has prepared a Consensus Document on keloid and hypertrophic scar treatment guidelines. These guidelines are simple and will allow even inexperienced clinicians to choose the most appropriate treatment strategy. The Consensus Document is provided in this article. It describes (1) the diagnostic algorithm for pathological scars and how to differentiate them from clinically similar benign and malignant tumors, (2) the general treatment algorithms for keloids and hypertrophic scars at different medical facilities, (3) the rationale behind each treatment for keloids and hypertrophic scars, and (4) the body site-specific treatment protocols for these scars. We believe that this Consensus Document will be helpful for physicians from all over the world who treat keloids and hypertrophic scars.
Expectations of breast-conserving therapy: a qualitative study
Authors: Fuzesi Sarah , Becetti Karima , Klassen Anne F. , Gemignani Mary L. , Pusic Andrea L.
Published: December 2019

Background

Early-stage breast cancer is often treated with breast-conserving therapy (BCT), including lumpectomy with radiation therapy. Patients’ expectations of BCT remain largely unknown. Expectations affect perceptions of treatment-related experiences and health-related quality of life (HR-QOL) outcomes. Our primary aim was to describe expectations of BCT among patients with early breast cancer through qualitative methods. Our secondary aim was to inform preoperative patient education and improve the patient experience through knowledge.

Methods

We used a grounded-theory approach to investigate a convenience sample of 22 women with stage I and II breast cancer who were treated with BCT at a single hospital in New York City between May and August 2016. Semi-structured interviews were conducted in person and by telephone. Open-ended questions covered participants’ expectations of treatment experiences and outcomes. Data was analyzed in a line-by-line approach to identify emergent themes related to patient expectations. Interviews continued until no new themes emerged.

Results

Analysis of data identified the following themes related to patient expectations of BCT: experience of cancer care, recovery, appearance, and HR-QOL. Despite preoperative informed consent and teaching, participants expressed few expectations preoperatively, owing to a lack of knowledge about the process of care. Lack of expectations preoperatively was compensated with available care and resources postoperatively.

Conclusions

Patients in our sample had a surprisingly limited understanding of what to expect during treatment with BCT. Despite available information and preoperative teaching, patients have a clear knowledge gap regarding BCT. These findings suggest patients often undergo cancer treatment with trust rather than complete understanding of the process. This data may be used to enhance preoperative discussions aimed at preparing patients for surgery and treatment.
MRSA screening and spa gene detection in isolates from healthcare workers at ophthalmology hospital in Egypt
Authors: Haggag Maha G. , Aboelnour Amal E. , Al-Kaffas Mai
Published: December 2019

Background

Staphylococcus aureus has a major role in different types of eye infections as conjunctivitis, keratitis, and endophthalmitis. Methicillin-resistant Staphylococcus aureus (MRSA) was almost restricted to hospitals, but its prevalence has been increased in people outside hospitals. The cell wall of Staphylococcus aureus has protein A which can bind to the Fc portion of IgG. This ptnA is encoded by surface protein A of Staphylococcus aureus (spa) gene that contains a highly polymorphic sequence which is composed of repeats of 24-bp. Sequence typing of the spa gene repeat region is used to study the epidemiology of MRSA. The purpose of this study was screening of MRSA strains among healthcare workers (HCWs) in the Hospital of the Research Institute of Ophthalmology (RIO), Giza, Egypt, and detecting spa gene in their DNAs by PCR.

Results

In the present study, 81 samples from healthcare providers in the hospital of the Research Institute of Ophthalmology, Egypt, were screened for MRSA. Out of these 81 samples, 41 isolates (50.6%) were identified as coagulase-positive Staphylococcus aureus. Twelve staphylococcal isolates were resistant to both oxacillin and cefoxitin, and those were identified as MRSA with a percentage of 14.8% (12/81). Conventional PCR could detect spa gene in 10 out of 12 DNA MRSA with a percentage of 83.3% (10/12).

Conclusion

In the present study, the prevalence of MRSA in HCWs was 14.8%. Since amplification of spa gene by PCR is a necessary preliminary step for spa typing of MRSA and since using different primers for spa gene amplification might affect PCR results, then proper selection of the primers and thermal cycling reaction conditions are recommended for PCR performance and spa typing.
Characteristics of Patients With ROS1+ Cancers: Results From the First Patient-Designed, Global, Pan-Cancer ROS1 Data Repository
Authors: Parikh Divya A. , Walia Guneet , Freeman-Daily Janet , Hennink Merel , Tomalia Tori , Buonanno Lysa , Goldman Lisa , Addario Bonnie , Patel Manali I.
Published: December 2019

PURPOSE:

The discovery of driver oncogenes, such as ROS1, has led to the development of targeted therapies. Despite clinical advancements, gaps remain in our understanding of characteristics of patients with ROS1-positive ( ROS1+) cancers. The purpose of this study was to comprehensively assess demographic, clinical, and environmental characteristics associated with ROS1+ cancers worldwide.

METHODS:

In collaboration with a panel of patients with ROS1+ cancer, we designed and conducted a 204-question online assessment regarding the demographic, clinical, and environmental factors of patients with ROS1+ cancers. We invited patients with ROS1+ cancers to participate in the study from May 2016 to December 2018.

RESULTS:

A total of 277 patients from 18 countries worldwide responded and completed at least 90% of the survey. The majority of respondents were female (n = 191; 69%), non-Hispanic white (n = 202; 73%), never-smokers (n = 180/240; 75%). Most were diagnosed with lung cancer (n = 261/277; 94%) and stage IV disease (n = 201/277; 76%). The majority received chemotherapy in first (n = 137/199; 69%) and second (n = 103/199; 52%) lines of therapy. For patients diagnosed with lung cancer after the availability of crizotinib (n = 199), only a minority (n = 55/199; 28%) reported receiving crizotinib in the first line of therapy.

CONCLUSION:

This study is the first global, patient-designed approach, to our knowledge, to comprehensively assess demographic, clinical, and environmental characteristics associated with ROS1+ cancers. Future efforts include assessing these characteristics as well as patient-reported outcomes and treatment responses longitudinally.
Pilot Trial of a Combined Oncologist-Patient-Caregiver Communication Intervention in Singapore
Authors: Malhotra Chetna , Rajasekaran Tanujaa , Kanesvaran Ravindran , Yee Alethea , Bundoc Filipinas G. , Singh Ratna , Tulsky James A. , Pollak Kathryn I.
Published: December 2019

PURPOSE:

High-quality end-of-life cancer care requires oncologists to communicate effectively and patients/caregivers to be participatory. However, most communication interventions target either but not both. We aimed to pilot a potentially disseminable combined oncologist-patient/caregiver intervention to improve oncologist empathic responses, discussions of prognosis and goals of care, and patient/caregiver participation. We assessed its feasibility, acceptability, and preliminary efficacy.

METHODS:

Between June 2018 and January 2019, we conducted a pilot 2-arm cluster trial in Singapore, randomly assigning 10 oncologists in a 1:1 ratio to receive the combined intervention or usual care. Intervention arm oncologists received online communication skills training, and their patients received a brief prompt sheet before consultations. We audio recorded consultations with 60 patients with stage IV solid malignancy and analyzed 30 in the postintervention phase. The study was not powered for statistical significance.

RESULTS:

Participation rates for oncologists and patients were 100% and 63%, respectively. All oncologists completed the online training within an average of 4.5 weeks; 73% of the patients selected at least 1 question in the prompt sheet. Compared with the control arm, intervention arm oncologists had more empathic responses in total (relative risk [RR], 1.66) and for every patient/caregiver negative emotion (RR, 2.01). Their consultations were more likely to involve discussions of prognosis (RR, 3.00) and goals of care, and their patients were more likely to ask a prognosis-related question (RR, 2.00; P > .05 for all).

CONCLUSION:

The combined oncologist-patient/caregiver intervention is feasible and acceptable and has the potential to improve communication within consultations.
Corporate finance
Authors: Balynin Igor' , Vlasova Natal'ya , Gubernatorov Aleksey , Koreckaya Lyudmila , Kuznecov Dmitriy , Lomov Evgeniy , Nikerova Tat'yana , Stel'mashenko Natal'ya , Teslenko Irina , Chekushov Andrey , Shmeleva Lyudmila
Published: December 2019

The textbook deals with the organization of corporate management in the innovation and digital economy, describes the direction of investment policy and the mechanism of its implementation in the activities of the Corporation. Special attention is paid to the mechanisms and methods of financing the Corporation's activities, as well as applied aspects of modeling business processes and their effectiveness.
Meets the requirements of the Federal state educational standards of higher education of the last generation.
It is intended for students studying in the areas of "management" and "Economics", and can also be useful for graduate students and teachers.
Methodology and theory of social work
Authors: Pavlenok Petr
Published: December 2019

The textbook discusses the methodological and theoretical foundations of social work. The problems of scientific identification of social work, theoretical problems of social work as a social phenomenon and the basis of educational and professional practice, the main scientific concepts and their place in the system of social Sciences, methods of theoretical research in social work, as well as the problems of the relationship of social work and social policy, management problems in social work.
Meets the requirements of the Federal state educational standards of higher education of the last generation.
It is intended for students of higher educational institutions studying in the direction of training 39.04.02 "Social work", degree (qualification) "master". It can be recommended to teachers, graduate students, practical social workers and anyone interested in this issue.
Storage Stability of Spray Dried Nigella Sativa (Ranunculaceae Family) Instant Beverage Powder: Effect of Carrier Agents on the Physicochemical, Phenolic Compounds and Antioxidant Properties
Authors: Varastegani Boshra , Lubowa Muhammad , Teixeira José António , Easa Azhar Mat
Published: December 2019

The study assessed the effect of carrier agent’s maltodextrin and gum Arabic on the storage stability of spray dried Nigella sativa powder packed in low-density polyethylene bags and stored at maximum 4°C for up to 12 months. At 0, 3, 6, 9, and 12 months intervals the samples were assessed for changes in caffeine content, moisture content, water activity, colour, solubility capacity, bulk density, and antioxidants activity as total phenolic content (TPC) and total flavonoid content (TFC). After 12 months storage, a 61-68% loss in TPC and TFC was observed and anti-oxidant activity had reduced by 70%-72%. Overall, water activity and moisture content increased with a decrease in total antioxidant activity, accompanied by a significant decrease in caffeine content. No significant changes were observed in solubility capacity and bulk density of N. sativa powder.
The Spectrum of Disordered Eating Attitudes Among Female University Students: A Cross-Sectional Study
Authors: Albrahim Tarfa , Alrubaish Anwar Abdullah , Alfadhliah Jewaher Turki Saleh , Alaskar Manal Khalid , Alatawi Mona Abdulla , Aldekhayyil Sara Abdullah
Published: December 2019

To explore the prevalence of disordered eating attitudes among the students of the Princess Nourah Bint Abdulrahman University (PNU), in Riyadh, Saudi Arabia. Methods: In this cross-sectional study, 396 (18-24 years) undergraduate students from the PNU were requested to participate, after acquiring their verbal consent. The two-part questionnaire included the demographic and anthropometric data like age, weight and height in the first part, while the assessment of the disordered eating attitudes according to the tools listed in the Eating Attitude Test 26 (EAT-26) were included in the second part. A total score of 20 or more on questions 1-26 was classified as being at risk of eating disorders. The study showed 145 students (36.8%) in all, fell under the class of high level of concern for an eating disorder, registering a score of 20 or higher on the EAT-26. With respect to the EAT score among the BMI categories marked differences were evident on the EAT items, feeling extremely guilty after eating, occupied with a desire to be thinner, burning up calories during exercise, preoccupied with the thought of having fat on my body, eating diet food, feeling uncomfortable after eating sweets and engaging in dieting behavior, having gone on eating binges where I feel I may not be able to stop and feeling that others would prefer if I ate more food and other people think I am too thin. Besides, in comparison to students with normal weight, students who were underweight, overweight, and obese exhibited considerable disparities on the total EAT score. More than one third (36.6%) of females at PNU university, Saudi Arabia had disordered eating attitudes. The present study revealed that female students require awareness regarding proper nutrition.
Latest clinical research
Authors: Greener Mark
Published: December 2019

Mark Greener rounds up the latest research of interest to primary care nurses
El ocio familiar del alumnado de Educación Secundaria Obligatoria en Galicia
Authors: Varela Crespo Laura , Maroñas Bermúdez Andrea
Published: December 2019

INTRODUCCIÓN. La familia, como agente socializador, tiene un gran peso en la construcción de los itinerarios de ocio, ya que ejerce una gran influencia en la configuración de las prácticas lúdicas que experimentan sus hijas e hijos durante la etapa infantil y juvenil. Además, el género es un factor significativo que incide en la esfera familiar y en el grupo de iguales, observándose diferencias en el tiempo disponible, la tipología de actividades practicadas y la configuración del acompañamiento. MÉTODO. Este trabajo tiene por objetivos: 1) analizar la importancia del ocio familiar del alumnado de Educación Secundaria Obligatoria en función del nivel de estudios de sus progenitores y 2) estudiar la influencia del género en las prácticas de ocio en familia. La metodología utilizada es de corte cuantitativo, empleando para la recogida de información un cuestionario diseñado ad hoc, con un total de 2.187 casos válidos. RESULTADOS. Los datos obtenidos informan de una relación directamente proporcional entre el nivel educativo de los progenitores y la importancia concedida al ocio en el seno familiar, así como de la existencia de notables diferencias de género: mientras ellas se decantan por actividades artístico-culturales o ir de compras, la práctica físico-deportiva y el uso de la tecnología sigue estando más masculinizada. DISCUSIÓN. Las conclusiones apuntan a la existencia de una brecha educativa y de género en los tiempos de ocio familiar que perjudica especialmente a las mujeres. En estas circunstancias se proponen como retos para la pedagogía-educación del ocio: de un lado, revalorizar el tiempo de ocio familiar como un agente clave en el tránsito hacia un ocio más autónomo y saludable; y de otro lado, educar en un ocio superador de los sesgos de género.
¿Qué tipo de maestro valora la sociedad actual? Visión social de la figura docente a través de twitter
Authors: Colomo Magaña Ernesto , Aguilar Cuesta Ángel Ignacio
Published: December 2019

INTRODUCCIÓN. El presente artículo se centra en conocer las características que se valoran de los maestros por parte de la sociedad en la actualidad. Partiendo de la efeméride del Día Mundial del Docente, promovido por la UNESCO y otros organismos internacionales, se examina la visión que se traslada en Twitter sobre la identidad profesional de los docentes. MÉTODO. Se utiliza una metodología mixta (cualitativa y cuantitativa) para el análisis de los 1.441 tweets originales recolectados sobre la efeméride del hashtag #DíaMundialDelDocente. Para la categorización y análisis de la información, se han utilizado cuatro tipologías de maestros diferenciadas por los rasgos y actitudes que las componen: el maestro personal y auténtico, que genera relaciones educativas y personales positivas con el alumnado; el maestro transmisor de historias, que enriquece sus lecciones y las traslada de forma apasionada y motivadora; el maestro motivador para el aprendizaje, que domina los escenarios y recursos para implementar procesos óptimos de aprendizaje; y el maestro como agente de cambio social, que entiende la educación como el medio para transformar y mejorar la realidad. RESULTADOS. Los resultados denotan una preferencia a nivel social por las características y rasgos del maestro auténtico y personal, donde destacan aspectos como ser ejemplo para el alumnado, los vínculos afectivos positivos o la vocación como factor identitario. DISCUSIÓN. Los resultados obtenidos sitúan al maestro auténtico y personal como la tipología más valorada a nivel social, quedando el resto de arquetipos con una presencia testimonial. Este hecho permite una reflexión sobre qué competencias, destrezas y habilidades conforman la visión del maestro ideal para la sociedad actual con el fin de favorecer su inclusión en la formación inicial y continua de los maestros.
Study on how to improve visibility of transparent display for augmented reality under various environment conditions
Authors: Kim Jeong-Sik , Lee Seung-Woo
Published: December 2019

In this paper, a psychophysical investigation to improve a visibility of a transparent display is presented. A new illuminance measurement method for the transparent display, named eye illuminance, is proposed. Through a psychophysical experiment, it is found that the eye illuminance is strongly related with the visibility of the transparent display regardless of its background condition. This paper finds out the optimum emission luminance range of the transparent display under various illuminant conditions. Also, the contrast ratio for visibility is analyzed and it is found that a higher contrast ratio is not needed to provide a visually better image under a brighter ambient environment. In conclusion, our findings will contribute to an auto brightness control technology to improve the visibility of the transparent display for augmented reality devices.
Highly sensitive transient reflection measurement in extreme ultraviolet region for tracking carrier and coherent phonon dynamics
Authors: Kato Keiko , Mashiko Hiroki , Kunihashi Yoji , Omi Hiroo , Gotoh Hideki , Oguri Katsuya
Published: December 2019

A highly sensitive method for detecting transient reflection in the extreme ultraviolet (XUV) region was developed on the basis of high-order harmonics for tracking carrier and coherent phonon dynamics. The use of lock-in detection and boxcar integration enables us to observe optical modulation (ΔR/R) as high as 1 × 10−4, and the data acquisition takes only four minutes. XUV transient reflections of bismuth exhibited exponential decay originating from excited carriers and periodic oscillation originating from A1g optical phonons. The linear power dependence of the electronic and phonon amplitudes indicated that one-photon excitation occurred under the experimental conditions. The cosine of the initial phase of the phonon oscillation revealed that a displacive excitation mechanism contributed to phonon generation. The phonon parameters obtained by the XUV and NIR probes were consistent even though their penetration depths were different. The result indicated that the XUV and NIR pulses probe the same excited region, which should be near the surface due to the short penetration depth of the NIR pump pulses. The present highly sensitive means of detecting XUV transient reflections in solid-state materials could be utilized for detecting attosecond dynamics in the future.
Time-delay signature concealment of chaos and ultrafast decision making in mutually coupled semiconductor lasers with a phase-modulated Sagnac loop
Authors: Ma Yuanting , Xiang Shuiying , Guo Xingxing , Song Ziwei , Wen Aijun , Hao Yue
Published: December 2019

We propose and experimentally demonstrate the generation of dual-channels chaos with time delay signature (TDS) concealment by introducing a phase-modulated Sagnac loop in mutually coupled semiconductor lasers (MCSL). Furthermore, we demonstrate the utilization of the dual-channels chaos to solve multi-armed bandit (MAB) problem in reinforcement learning. The experimental results agree well with the numerical simulations. For the purpose of comparison, the MCSL with a conventional Sagnac loop is also considered. It is found that the TDS of dual-channels chaotic signals can be better concealed in our proposed system. Besides, the proposed system allows for a better decision making performance in MAB problem. Moreover, compared with the one-channel chaotic system, the proposed dual-channels chaotic system achieves ultrafast decision making in parallel, and thus, is highly valuable for further improving the security of communication systems and the performance of photonic intelligence.
Comparison of Two Different Immunohistochemical Quadruple Staining Approaches to Identify Innate Lymphoid Cells in Formalin-fixed Paraffin-embedded Human Tissue
Authors: de Boer Onno J. , Krebbers Gabrielle , Mackaaij Claire , Florquin Sandrine , de Rie Menno A. , van der Wal Allard C. , Teunissen Marcel B.M.
Published: December 2019

Lack of specific markers for innate lymphoid cells (ILCs) limit our knowledge on their spatial organization in situ. We compared two quadruple-color staining protocols for detection of the three principal human ILC subsets in formalin-fixed paraffin-embedded specimens. ILC subset–associated archetypical transcription factors (TFs) T-bet, GATA3, and RORγt were used as positive identifiers in combination with lymphoid lineage markers to exclude non-ILCs. One method (“virtual quadruple staining”) comprised of iterative single stainings on the same section performing digital scanning and subsequent immunoglobulin and chromogen stripping after each staining round. The second technique (“true-color quadruple staining”) comprised sequential double stainings with permanent colors. Both protocols appeared suitable for accurate detection of each ILC subset, and as added result, concomitant visualization of their T cell subset counterpart. Only true-color quadruple staining enabled simultaneous detection of all three ILC subsets within one section. Furthermore, we found that type 3 and type 1 ILCs (ILC1s) represent the major subsets in colon and that part of the ILC1s typically colocalizes with blood vessels. Our data highlight the utility of TFs combined with lineage markers for the identification of ILC subsets and proposed workflow opens the way to gain deeper insight of their anatomical distribution.
Media Pengenalan Safety Behavior untuk Anak Usia Dini
Authors: Hidayatulloh M. Agung
Published: December 2019

Early child is known as an individual who is vulnerable to a number of events that threaten his personal safety. These risks make the government of the Republic of Indonesia (RI) entrust teachers to teach early about safety behaviors. This article discusses the media that teachers use to introduce safety behaviors in early childhood. This qualitative study was conducted in four early childhood education units in Salatiga, Semarang, and Boyolali. Data collection techniques used were observation, interview, and documentation. It was stated that the teacher introduces safety behavior through the media that supports three children's learning styles, namely auditory, visual, and kinesthetic. The media are in the form of healthy walk, educative teaching aids (APE) of traffic, helmets, switches and sockets, scissors, oral, doormats and cloths, as well as pickup cards. The research findings imply that the introduction of safety behaviors should be adapted to the context.
Research Data Management and Data Sharing among Research Scholars of Life Sciences and Social Sciences
Authors: PM Naushad Ali , Saeed Sidra
Published: December 2019

This study investigates perception of research scholars towards research data management and sharing. A survey was conducted among research scholars from Faculty of Life Sciences and Social Sciences, Aligarh Muslim University (AMU). In total, 352 participants filled out the questionnaire. The study shows that research scholars ofFaculty of Social Sciences are more willing to share their research data as compared to Research Scholars of Life Sciences. Contributing to scientific progress and increasing research citations and visibility were the key factors that motivated researchers to share data. However, confidentiality and data misuse were the main concerns among those who were unwilling to share. Finally, some recommendations to improve the of data management and sharing practices are presented.
Annual Index to DJLIT, Vol 39, 2019
Authors: DJLIT Editor
Published: December 2019

ANNUAL INDEX TO DJLIT, VOLUME 39, 2019
Diversity of D-loop mitochondrial DNA (mtDNA) sequence in Bali and Sumba Ongole cattle breeds
Authors: Jakaria J. , Musyaddad T. , Rahayu S. , Muladno M. , Sumantri C.
Published: December 2019

This study aimed to investigate the diversity of the complete sequence of D-loop mitochondrial DNA (mtDNA) in Bali and Sumba Ongole (SO) cattlebreeds. A total of 24 blood samples were collected from Bali cattle (19 heads) and SO cattle (5 heads), and were extracted and then analyzed to obtain the sequence of D-loop mt DNA.Multiple alignments of the whole sequence of D-loop mtDNA were determined using clustal W. Genetic distance was calculated using a p-distance method, while the genetic tree was constructed using neighbor-joining (NJ) based on MEGA 6. Haplotype number, haplotype diversity (Hd) and nucleotide diversity (Pi) were analyzed using DnaSP version 6. As a result, the sequence of D-loop mtDNA in Bali cattle (921-1119 bp) and SO cattle (913 bp) was reported to have 8 and 4 haplotypes. Hd and Pi of Bali cattle reached 0.625±0.139 and 0.0266±0.0145, respectively, which wwere different from that of SO cattle, namely 0.900±0.1610 and 0.0064±0.0015, respectively. Specifically, we found 22 bp-repetitive nucleotide in Bali cattle, existing 3-9 times with a length of 66-198 bp present in D-loop mtDNA. This unique feature did not exist in SO cattle. Genetic distance and genetic tree determined according to sequence in hypervariability (HV-1) region of D-loop mtDNA (166 bp) resulted in satisfied separation, successfully classifying Bos javanicus, Bos indicus, and Bos taurus cluster.
Association of IGFBP-3 gene polymorphism g. 3.930 G>A with birth size and birth weight in crossbred beef cattle
Authors: Hartatik T. , Priyadi D. A. , Panjono P. , Bintara S. , Ismaya I. , Budisatria I. G. S. , Widyobroto B. P. , Agus A.
Published: December 2019

Crossing between cattle breeds is the one way to improve the genetic quality of cattle. Controlling crosses using genetic markers will speed up the process. The IGFBP-3 gene is a potential marker of selection due to its role in regulating growth and metabolism in cattle. The aim of this study was to determine the effect of genotype on birth size and birth weight using IBFBP-3 gene marker. A total of 32 cattle consisted of 10 Brahman Cross cattle, 14 cattle results of Brahman Cross cow crosses with Belgian Blue bull, and 8 cattle results of Brahman Cross cow crosses with Wagyu bull. Sequences of 563 bp, including the part intron 2, exon 3, and the part intron 3. Genotyping was done by sequencing method and PCR-RFLP method with the restriction enzyme PvuII. An SNP was identified at location g 3,930 (G>A). Two genotypes were observed, namely GA and GG. The genotype did not affect the performance of birth (body weight, body length, height at withers, heart girth) of the research sample. Birth traits are influenced by the cattle breed, it can be seen that Brahman Cross cattle have a body length that is bigger than the other crossbred.
Effect of dietary simvastatin and L-carnitine supplementation on blood biochemical parameters, carcass characteristics and growth of broiler chickens
Authors: Panahi H. , Bouyeh M. , Behzadpour D. , Seidavi A. , Simões J. , Tufarelli Vincenzo , Staffa V.N. , Tinelli A. , Ayasan T. , Laudadio V.
Published: December 2019

The aim of this study was to evaluate the effect of simvastatin (SIM) and L-carnitine (LC) additives and their interactions, on productive performance and carcass quality of broilers. For this purpose, a feeding trial was conducted, under 3×3 factorial design, using SIM at 0, 1 or 2 g/kg level and LC at 0, 150 or 300 mg/kg level in a basal-diet and originating a total of nine treatments: T1 (control-diet, 0/0), T2 (0/150), T3 (0/300), T4 (1/0), T5(1/150), T6 (1/300), T7 (2/0), T8 (2/150), and T9 (2/300). Feed intake was higher in T2 (4716 g), T7 (4722 g) and T9 (4698 g) than in T1 (4545 g; P<0.05) considering the last growing phase (35-42 days) or whole 42-day production cycle. An improvement of feed efficiency was also observed in T8 (1.64) and T9 (1.67) when compared to T1 (1.77; P<0.05), and these were mainly due to SIM × LC interactions (P<0.05). The LC influenced positively (P<0.05) the weight of eviscerated carcass, breast, drumsticks and abdominal fat, as well as plasma triglycerides level. This findings suggests that the combination of SIM and LC additives have a positive influence on growth performance and carcass traits of broiler chickens.
The population, protein profile and ultrastructure of Ascaridia galli in chicken treated using Areca catechu crude aqueous extract
Authors: Mubarokah W. W. , Nurcahyo W. , Prastowo J. , Kurniasih K.
Published: December 2019

The study aimed at investigating the population, the protein profile and the ultrastructure of adult worms in the intestine of domestic chicken treated using Areca catechu crude aqueous extract. Fifty domestic female chickens of 6 weeks of age were assigned to 5 groups. Group A (negative control) was not given any treatment and any drug. Groups B, C and D were given the treatment at the doses of 26 mg/mL, 53 mg/mL and 79 mg/mL, respectively. Group E (positive control) was given Pyrantel®. Necropsy was conducted to all of the chickens 14 days after the treatment. Adult worms were collected and counted. The worms used in Sodium Dodecyl Sulfate Polyacrylamide Gel Electrophoresis (SDS-PAGE) and Scanning Electron Microscopy (SEM) were those collected from the jejunum of the chickens in the groups A, B and C. The biggest number of the worms was found in the jejunum. The results of electrophoresis showed that the dose 53 mg/mL gave fewer protein bands than the negative control (21:12 ratio), while the results of the SEM showed that there was cuticle damage and anterior labia abrasion at the dose of 53 mg/mL. The Areca catechu crude aqueous extract showed anthelmintic activity potential by reducing the number of the adult worms, lowering their protein profile and damaging the A. galli worms in the intestine.
Implication of feed restriction during growth period on the growth hormone profiles and morphology ovary of quail hen (Coturnix coturnix japonica)
Authors: Hertamawati R.T. , Soedjarwo E. , Sjofjan O. , Suyadi S
Published: December 2019

The aim of this research was to evaluate the effect of feed restriction on growth hormone profiles and ovarian morphology during the growth period. Three hundred 14-day-old quails were used. The quails were maintained on two feeding restriction programs: two dietary regimes based on metabolizable energy (ME), R1 = 2900 kcal/kg and R2 = 2800 kcal/kg, and 3 quantitative feed restriction diets, P0 = 100% ad libitum; P1= 90% ad libitum and P2 = 80%ad libitum (n=300). Each group (n=50) was processed with five replications, 10 birds in each replicate. The change in growth hormone was determined at 28, 35, 42, and 49 days of age, while ovarian morphology was determined at sexual maturity. The results indicated that feed restriction induced a significant increase in growth hormone and insulin-like growth factor-1 after re-feeding. There was no significant effect caused by the rationing of metabolizable energy. The number of large yellow follicles was not different between quails fed with 100% ad libitum and 90% ad libitum. However, feed restriction significantly increased the number of small yellow follicles. In conclusion, the feed could be restricted to 90% ad libitum with a 2900 kcal/kg ration of ME and fed during the starter period (14 to 42 days of age) without influencing ovarian morphology in quails.
Magnetically separable Ru-containing catalysts in supercritical deoxygenation of fatty acids
Authors: Stepacheva Antonina A. , Lugovoy Yury V. , Manaenkov Oleg V. , Sidorov Alexander I. , Matveeva Valentina G. , Sulman Mikhail G. , Sulman Esther M.
Published: December 2019

In the current paper, the possibility of the use of magnetically separable catalysts containing ruthenium oxide species in the supercritical deoxygenation of stearic acid for producing of the second generation of biodiesel is reported. Three different supports (silica, ceria, and hypercrosslinked polystyrene) were used for the stabilization of magnetic nanoparticles (MNPs) and Ru-containing particles. The effect of support on the magnetic properties as well as the catalytic activity of the obtained systems was studied. All synthesized catalysts were shown to provide high stearic acid conversion (up to 95 %). The highest yield of C17+ hydrocarbons (up to 86 %) was observed while using the Ru–Fe3O4-HPS system. Ru–Fe3O4-HPS was characterized by the high values of the specific surface area (364 m2/g) and saturation magnetization (4.5 emu/g). The chosen catalytic system was found to maintain its catalytic activity for a minimum of 10 consecutive cycles.
Safety Analysis of an Automobile Workshop Using Qualitative Risk Assessment Method and Risk Analysis Through the Structural Equation Modelling
Authors: Akintimehin Ayomide Olawale , Oke Sunday Ayoola
Published: December 2019

Automobile repair service hazards are risk factors for multiple severe accidents, and scientific proof reveals a relationship between repair activity hazards and accidents in the auto-mechanic workshop. In this research, the investigators approximated the impact of risk factors for automobile repair activities, using novel parameters, for severity of hazards and influences on subjects, and based on literature. Next, insights into the relationship between latent variables which are appraised by manifest variables using the structural equation modelling were pursued. The respondents answered questionnaires on probability of hazard occurrence, severity and some identified measured variables. The authors appraised 44 out of the 80 and 98 out of 99 distributed questionnaires for the first and second modules, respectively. The risk levels ranged between low and medium for the medium scale establishment due to the nature of work done in the automobile repair centre which exposes the workers to the level of risk. For the second module involving the use of structural equation modelling, the factor loading was the least for safety behaviours (0.06) and highest for machine efficiency (0.90). Of the fifteen hypotheses formulated six were accepted. It is concluded that the safety behaviour of workers depends safety on the workers in the firm irrespective of other factors such as management commitment to safety, environmental contributions and safety, communications. Understanding the impact of risk factors for automobile repair activities in workers is necessary in elevating awareness absent these parameters and to eliminate accidents.
A series of new layered lithium europium(II) oxoniobates(V) and -tantalates(V)
Authors: Funk Christian , Köhler Jürgen , Schleid Thomas
Published: December 2019

The new Ruddlesden-Popper-related phasesAn+1BnO3n+1(n = 3) with the compositions Li2Eu2Nb3O10, Li2Eu1.5Ta3O10, Li2EuKNb3O10, and Li2EuKTa3O10were synthesized by solid-state reactions from Li2[CO3] (+ K2[CO3]) and the corresponding refractory metals along with their oxides in a high-frequency furnace at temperatures aboveT = 1600°C. Their structures have been determined by single-crystal X-ray diffraction studies. Characteristic features are triple layers of corner-sharing [MO6]7−octahedra (M = Nb and Ta), which are connected via [LiO4]7−tetrahedra. The Eu2+cations are cuboctahedrally surrounded by 12 oxygen atoms and according to the Eu–O distances of around 275 pm, they have the oxidation state +2, as confirmed by XPS measurements. In the potassium-containing samples they share their positions with K+cations. The black compounds are stable in air at room temperature. Measurements of the magnetic susceptibilities in the range ofT = 5–300 K revealed Li2Eu2Nb3O10, Li2Eu1.5Ta3O10and Li2EuKTa3O10to be paramagnetic without any ordering.
Distribution of Midbrain Cholinergic Axons in the Thalamus
Authors: Huerta-Ocampo Icnelia , Hacioglu-Bay Husniye , Dautan Daniel , Mena-Segovia Juan
Published: December 2019

Cholinergic transmission is essential for adaptive behavior and has been suggested to play a central role in the modulation of brain states by means of the modulation of thalamic neurons. Midbrain cholinergic neurons from the pedunculopontine nucleus (PPN) and the laterodorsal tegmental nucleus (LDT) provide dense innervation of the thalamus, but a detailed connectivity mapping is missing. Using conditional tracing of midbrain cholinergic axons in the rat, together with a detailed segmentation of thalamic structures, we show that projections arising in PPN and LDT are topographically organized along the entire extent of the thalamus. PPN cholinergic neurons preferentially innervate thalamic relay structures, whereas LDT cholinergic neurons preferentially target thalamic limbic nuclei. Moreover, both PPN and LDT provide a dense innervation of the intralaminar thalamic nuclei. Notably, we observe a differential synaptic density that functionally dissociates between PPN and LDT innervation. Our results show that midbrain cholinergic neurons innervate virtually all thalamic structures and this innervation is functionally segregated.
Midkine-a Is Required for Cell Cycle Progression of Müller Glia during Neuronal Regeneration in the Vertebrate Retina
Authors: Nagashima Mikiko , D'Cruz Travis S. , Danku Antoinette E. , Hesse Doneen , Sifuentes Christopher , Raymond Pamela A. , Hitchcock Peter F.
Published: December 2019

In the retina of zebrafish, Müller glia have the ability to reprogram into stem cells capable of regenerating all classes of retinal neurons and restoring visual function. Understanding the cellular and molecular mechanisms controlling the stem cell properties of Müller glia in zebrafish may provide cues to unlock the regenerative potential in the mammalian nervous system. Midkine is a cytokine/growth factor with multiple roles in neural development, tissue repair, and disease. Inmidkine-aloss-of-function mutants of both sexes, Müller glia initiate the appropriate reprogramming response to photoreceptor death by increasing expression of stem cell-associated genes, and entering the G1phase of the cell cycle. However, transition from G1to S phase is blocked in the absence of Midkine-a, resulting in significantly reduced proliferation and selective failure to regenerate cone photoreceptors. Failing to progress through the cell cycle, Müller glia undergo reactive gliosis, a pathological hallmark in the injured CNS of mammals. Finally, we determined that the Midkine-a receptor, anaplastic lymphoma kinase, is upstream of the HLH regulatory protein, Id2a, and of the retinoblastoma gene,p130, which regulates progression through the cell cycle. These results demonstrate that Midkine-a functions as a core component of the mechanisms that regulate proliferation of stem cells in the injured CNS.

SIGNIFICANCE STATEMENTThe death of retinal neurons and photoreceptors is a leading cause of vision loss. Regenerating retinal neurons is a therapeutic goal. Zebrafish can regenerate retinal neurons from intrinsic stem cells, Müller glia, and are a powerful model to understand how stem cells might be used therapeutically. Midkine-a, an injury-induced growth factor/cytokine that is expressed by Müller glia following neuronal death, is required for Müller glia to progress through the cell cycle. The absence of Midkine-a suspends proliferation and neuronal regeneration. With cell cycle progression stalled, Müller glia undergo reactive gliosis, a pathological hallmark of the mammalian retina. This work provides a unique insight into mechanisms that control the cell cycle during neuronal regeneration.
Meteorology influencing springtime air quality, pollution transport, and visibility in Korea
Authors: Peterson David A. , Hyer Edward J. , Han Sang-Ok , Crawford James H. , Park Rokjin J. , Holz Robert , Kuehn Ralph E. , Eloranta Edwin , Knote Christoph , Jordan Carolyn E. , Lefer Barry L.
Published: December 2019

In an environment with many local, remote, persistent, and episodic sources of pollution, meteorology is the primary factor that drives periods of unhealthy air quality and reduced visibility. The 2016 Korea-United States Air Quality (KORUS-AQ) field study provides a unique opportunity to examine the impact of meteorology on the relative influence of local and transboundary pollution. Much of the KORUS-AQ campaign can be grouped into four distinct research periods based on observed synoptic meteorology, including a period of complex aerosol vertical profiles driven by dynamic meteorology, stagnation under a persistent anticyclone, low-level transport and haze development, and a blocking pattern. These episodes are examined using a diverse archive of ground, airborne, and satellite data. While frontal boundaries are recognized as the primary mechanism driving pollution transport in eastern Asia, results show that they are not always related to sustained periods of hazardous air quality and reduced visibility at the surface. Significant long-range transport of pollution and dust was constrained to a few short events, suggesting that the majority of pollutants sampled during KORUS-AQ originated from local sources. A severe regional pollution episode is examined in detail, featuring dense haze and significant secondary particle formation within a shallow moist boundary layer. Observations during KORUS-AQ also highlight a rapid, 40 ppbv increase in ozone pollution as a strong sea breeze front traversed the Seoul Metropolitan Area. Representativeness of meteorology and pollution conditions measured by KORUS-AQ is considered by comparison with climatology. This analysis is an essential step toward improved local and regional forecasting of air quality and visibility.