bluuebunny/crossref_metadata_2025 huggingface dataset:
Peripheral Nerve Stimulation Using High-Frequency Electromagnetic Coupling Technology to Power an Implanted Neurostimulator with a Separate Receiver at the Superior Cluneal Nerve for Treatment of Chronic Back Pain Due to Neuralgia: A Retrospective Study
Authors: Lindley David
Published: January 2025

BACKGROUND: Low back pain is a highly prevalent condition with substantial costs. Superior cluneal neuralgia is present in up to 14% of low back pain cases. This etiology of back pain is often overlooked because the symptoms of superior cluneal neuralgia manifest similarly to those of other conditions, such as radiculopathy and sacroiliac joint pain. Peripheral nerve stimulation (PNS) is an emerging pain management modality used to treat various chronic pain conditions. This retrospective study will examine the outcomes of patients who have back pain caused by neuralgia and are treated with the permanent Freedom® PNS System (Curonix LLC) at the superior cluneal nerve.

OBJECTIVES: The primary objective was to examine the responder rate (proportion of patients who experienced greater than 50% relief) and changes in pain scores after the trial procedure. Secondary objectives included changes in pain scores from at least one month after permanent implantation, adverse event occurrences, changes in function and quality of life, and reductions in medication usage.

SETTING: This was a retrospective single-site study. All procedures were performed by the same interventional pain physician.

METHODS: A retrospective chart review was conducted to assess baseline and follow-up parameters. Inclusion criteria consisted of requirements that patients be 18 years or older and have a confirmed superior cluneal neuralgia diagnosis responsible for their pain presentation. Exclusion criteria included the presence of another active implanted device for pain management. The 11-point verbal rating scale (VRS) was used to assess pain scores.

RESULTS: Twenty-one patients were included in this study. All 21 responded to the trial procedure with a 77% average reduction in VRS scores. At the follow-up (mean = 11 months), 20 patients reported an average 57% reduction in pain scores with the verbal rating scale. The same proportion of patients reported improved function and quality of life. Five patients reported reduced medication usage, including one who stopped taking pain medication altogether. No complications were reported.

LIMITATIONS: We were limited to the data available in the patient charts since this was a retrospective study investigating the efficacy and safety of the Freedom® PNS System for patients with refractory chronic back pain.

CONCLUSION: When used to target the superior cluneal nerve, the Curonix Freedom® PNS System is an effective and safe treatment for neuralgia-caused chronic lower back pain resistant to conservative therapy.

KEY WORDS: Peripheral nerve stimulation, chronic pain, superior cluneal neuralgia, low back pain
Evaluation of human transforming growth factor -β and some biochemical markers in leukemia patients in Kirkuk city
Authors: Ali Taha Hadher , Faris Rija Firas
Published: January 2025

Acute myeloid leukemia is characterized by the infiltration of the bone marrow, blood, and other organs by proliferative, clonal, undifferentiated, and sometimes poorly differentiated cells that originate from the hematopoietic system. The primary objective of this study was to assess the levels of human transforming growth factor-β and several biochemical markers in individuals diagnosed with leukemia, and to determine their significance in the context of these cases. A cross-sectional study was conducted at the Kirkuk oncology center, which is situated within the Kirkuk Teaching Hospital. The investigation was carried out over the period spanning from January 2023 to May 2023. The research consisted of a total of 90 participants, with 60 individuals as patients' group and 30 healthy individuals as control group. The research encompassed individuals ranging in age from 18 to 70 years. The present finding has shown a statistically significant positive correlation (p-value 0.0086) between the presence of human transforming growth factor-β (TGF-β) in individuals with leukemia and those in the control group. Furthermore, a significant association was seen between the levels of serum creatinine in the patients and the control group. Also, the current study exists a statistically significant association between white blood cell (WBC) count, hemoglobin concentration, and platelet count (PLTs) in patients diagnosed with leukemia and individuals in a healthy control group.
ANALISIS WILLINGNESS TO PAY KERETA API KOMUTER SIDOARJO - INDRO
Authors: Putra Yuwanto Hafizhudin Alfin , Utomo Nugroho , Estikhamah Fithri
Published: January 2025

Tingkat perekonomian dan kepadatan penduduk yang tinggi meyebabkan Kabupaten Gresik, Kota Surabaya dan Kabupaten Sidoarjo memiliki mobilitas masyarakat yang tinggi pula, sehingga memerlukan layanan transportasi umum yang baik. Untuk itu, pada 10 Februari 2021 PT. Kereta Api Indonesia (Persero) Daerah Operasi 8 Surabaya merilis layanan kereta api penumpang di Kabupaten Gresik dengan mengoperasikan Kereta Api Komuter dengan relasi Stasiun Indro (Gresik) â€“ Stasiun Sidoarjo. Penelitian ini bertujuan untuk menentukan tarif yang sesuai dengan layanan Kereta Api Komuter Sidoarjo â€“ Indro menggunakan metode willingness to pay (WTP). Berdasarkan hasil penelitian, nilai willingness to pay pada perjalanan Kereta Api Komuter Sidoarjo â€“ Indro dengan tarif eksisting Rp 5.000 adalah sebesar Rp 7.700. sehingga tarif yang berlaku saat ini sudah sesuai dan masih dapat dinaikkan apabila disertai dengan peningkatan fasilitas serta pelayanan.
PEMETAAN KARAKTERISTIK ARUS LALU LINTAS DENGAN METODE GREENBERG PADA RUAS JALAN KOTA MALANG
Authors: Aldiansyah Fauzi Aldiansyah , Wibisana Hendrata
Published: January 2025

Volume ruas Jalan Jaksa Agung Suprapto cukup tinggi dan akan terus bertambah seiring berkembangnya jumlah penduduk. Maka dari itu perlu dilakukan analisis karakteristik arus lalu lintas. Pada penelitian ini pendekatan model matematis menggunakan metode Greenberg. Pada ruas Jalan Jaksa Agung Suprapto didapatkan hasil penelitian dan analisis menggunakan metode Greenberg dengan nilai R2 terbesarnya yaitu pada hari Jumâ€™at, tepatnya pada segmen 7 sebesar 0,89. Adapun nilai variabel yang didapatkan dari segmen ini yaitu, Volume Maksimum (Vm) sebesar 5523,05 smp/jam, Kecepatan Bebas (Uf) sebesar 73,01 km/jam,  Kecepatan Maksimum (Um) sebesar 9,98 km/jam, dan Kepadatan Jenuh (Dj) sebesar 1504,53 smp/km. Pengaplikasian Sistem Informasi Geografis dalam penelitian ini dilakukan dengan menggunakan hasil penelitian sebagai data atribut dalam peta tematik karakteristik lalu lintas.
ANALISIS METODE NILAI HASIL (EARNED VALUE) MENGGUNAKAN SIMULASI MONTE CARLO UNTUK MONITORING PROYEK PEMBANGUNAN JALAN
Authors: Iman Kamila Salsabila , Kamandang Zetta Rasullia
Published: January 2025

Kinerja proyek dinilai berdasarkan jadwal, biaya, dan kualitas. Pengukuran waktu dan biaya harus dilakukan secara teratur untuk mengidentifikasi apabila terdapat ketidaksesuaian terhadap rencana. Pada proyek pembangunan jalan XYZ di Provinsi Jawa Timur ditemukan adanya deviasi sebesar 20,707% pada minggu ke-19, sehingga diperlukan analisis konsep nilai hasil untuk mengetahui perkembangan proyek di masa mendatang. Untuk menganalisis penyebaran ketidakpastian proyek, digunakan simulasi Monte Carlo dengan memodelkan sistem dengan bilangan acak. Angka random yang dihasilkan merupakan angka diantara RAB minimum dan maksimum untuk setiap jenis pekerjaan yang ada pada proyek. Setelah dilakukan pengulangan sesuai jumlah iterasi yang didapatkan dengan nilai relative error 2%. Kemudian dianalisis grafik frekuensi dan distribusi normalnya, sehingga dapat diketahui bahwa proyek harus menyediakan biaya sebesar Rp 11.031.591.805,11, Rp 16.742.117.603,03, dan Rp 21.981.246.725,01 untuk evaluasi kinerja pada tinjauan prestasi 50%, 75%, dan 100%. Hasil perhitungan SPI di minggu ke-19 yakni sebesar 0,409, menunjukkan bahwa proyek terlambat dari jadwal. Selain itu, perhitungan TE menunjukkan proyek ini dapat diselesaikan dalam 508 hari atau 73 minggu.
ANALISIS DEFORMASI KOLOM TANAH GRANULAR MENGGUNAKAN METODE SMOOTHED PARTICLE HYDRODYNAMICS
Authors: Putri Aulina Reza , Rahayu Wiwik , Marthanty R. R. Dwinanti Rika
Published: January 2025

Gempa bumi berkekuatan besar sering memicu fenomena likuefaksi pada deposit tanah granular. Salah satu persitiwa likuefaksi besar di Indonesia terjadi saat gempa Palu 2018, yang menyebabkan kerugian ekonomi mencapai 911 juta USD. Salah satu mitigasi likuefaksi adalah mengevaluasi dampak yang ditimbulkannya. Fenomena likuefaksi dapat dimodelkan secara numerik, salah satunya menggunakan metode SPH. SPH adalah metode kontinum yang tidak menggunakan mesh dalam model numerik. Kelebihan metode SPH adalah kemampuannya memodelkan fenomena deformasi besar menggunakan pendekatan Lagrangian. Dalam penelitian ini, SPH digunakan untuk memodelkan keruntuhan tanah granular tersaturasi 2D berukuran 0,6 m x 2,0 m. Model konstitutif tanah yang digunakan adalah elasto-plastis, dimana deformasi plastis dihitung menggunakan kriteria kegagalan Drucker-Prager. Interaksi antara partikel tanah-air diwakilkan dengan gaya seepage. Pada model ini, tidak dimodelkan gaya dari luar selain gaya gravitasi. Hasil simulasi digunakan untuk menganalisis deformasi tanah granular.
REDESAIN STRUKTUR BAWAH BANGUNAN GEDUNG: STUDI KASUS PERENCANAAN PONDASI TAPAK GEDUNG SEKOLAH DASAR NEGERI (SDN) 12 MUNTEI, MENTAWAI
Authors: Fitria Winda , Misriani Merley , Roza Fielda
Published: January 2025

Kepulauan Mentawai termasuk salah satu daerah yang memanfaatkan sektor pariwisata untuk mendukung perkembangannya. Mentawai merupakan salah satu destinasi favorit wisatawan surfing dari mancanegara. Secara umum wisata di Kepulauan Mentawai memberikan dampak baik terhadap perekonomian daerah setempat. Pembangunan infrastruktur di Kepulauan Mentawai masih tertinggal dibandingkan kota lainnya di daerah Sumatera Barat. Semestinya proses pembangunan di Mentawai perlu mendapat perhatian serius mengingat Mentawai merupakan kawasan yang rawan bencana gempa dan tsunami. Peningkatan potensi gempa dan tsunami tidak diimbangi dengan kesiapan masyarakat dalam menghadapinya. Untuk mengurangi resiko korban jiwa pada daerah rawan gempa standar bangunan tahan gempa sangat penting untuk diterapkan. Bangunan tahan gempa harus diaplikasikan sejak tahapan perencanaan bukan hanya selama proses konstruksi saja. SDN 12 Muntei merupakan salah satu bangunan di Mentawai yang dapat digunakan untuk umum sebagai sekolah dasar. Pemeriksaan terhadap desain awal pondasi bangunan pada penelitian sebelumnya ditemukan bahwa kapasitas dukung izin pondasi tidak mampu memikul beban yang bekerja pada bangunan tersebut, sehingga perlu dilakukan desain ulang penampang pondasi. Setelah dilakukan desain ulang pondasi dengan jenis pondasi tetap pondasi tapak, direkomendasikan pondasi berada pada kedalaman (D) = 1.5meter dengan lebar (B)= 1.3 meter. Nilai SF untuk menentukan daya dukung izin (Qa) diambil sebesar 3.  Dari hasil perhitungan dengan dimensi penampang yang baru nilai Qa = 378.76 KN dan nilai beban maksimum bangunan yang bekerja (Pmaks) = 339 KN. Hasil analisis ini menunjukan bahwa penampang tersebut memenuhi syarat dan dapat digunakan
EMPRENDIMIENTO, CULTURA EMPRENDEDORA Y CULTURA DE EMPRENDIMIENTO: CARTOGRAFÍA CONCEPTUAL DESDE LAS TESIS UNIVERSITARIAS PERUANAS
Authors: Turpo Gebera Osbaldo , Chirinos-Tovar Karina , Huamán-Gutiérrez Robert , Flores-Ayquipa Alberto-Sebastián , Mamani-Quispe Diego , Huarca-Flores Paola
Published: January 2025

En el contexto global contemporáneo, el emprendimiento y su cultura se han convertido en elementos fundamentales para el desarrollo socioeconómico de los países, trascendiendo la simple creación de negocios lucrativos e integrando un conjunto más amplio de actitudes, habilidades y capacidades orientadas a la innovación y la solución de problemas. Este estudio analizó la concepción y evolución de los conceptos de Emprendimiento, Cultura Emprendedora y Cultura del Emprendimiento en el contexto peruano, con base en un análisis exhaustivo de 51 tesis de posgrado (maestría y doctorado) defendidas en diversas universidades peruanas. Para ello, se empleó la cartografía conceptual como metodología cualitativa, lo que permitió mapear, analizar y comparar las principales ideas y enfoques que han emergido en torno a estos temas a lo largo del tiempo. Los resultados del estudio revelan una marcada tendencia a priorizar el Emprendimiento desde una perspectiva predominantemente económica, enfocada en la creación de empresas y proyectos con impacto financiero directo; sin embargo, se identificaron limitaciones significativas en cuanto al desarrollo y fomento de la Cultura Emprendedora, que está más relacionada con la formación de actitudes, competencias y habilidades individuales orientadas al emprendimiento. Estos desafíos son particularmente evidentes en el sistema educativo peruano, en el cual aún no se han implementado de manera efectiva las estrategias necesarias para promover y fortalecer una verdadera cultura emprendedora. Además, el concepto de Cultura del Emprendimiento, que implica la integración del emprendimiento en el tejido social y educativo, aún no ha logrado consolidarse plenamente en el Perú. Este hallazgo subraya la necesidad de contextualizar adecuadamente estos conceptos y adaptarlos a la realidad socioeconómica y cultural del país, lo que garantizaría que su desarrollo contribuya efectivamente al progreso socioeconómico nacional.
ANÁLISE DOS CASOS DE HANSENÍASE E TUBERCULOSE PEDIÁTRICA NA FAIXA-ETÁRIA DE 1-9 ANOS NAS REGIÕS BRASILEIRAS DURANTE O PERÍODO DE 2013-2023
Authors: Both Lucas Mateus , Tensini Gabriela Rossatto , Dariva Esther Marcon , Craveiro Maria Eduarda Felhberg , Nardi Kamilla Isabel , Santos Júlia Ribas dos , Ciquelero Rodrigo , Moraes Camilla Carolina Tibes de , Silva Marcos Vinícius da , Fonini Maria Eduarda Schaparini
Published: January 2025

A tuberculose e a Hanseníase são duas doenças infecciosas causadas por micobactérias, bactérias conhecidas como “ácido-álcool resistentes”; a transmissão das duas doenças se dá principalmente pela disseminação dos patógenos por gotículas no ar provenientes de pessoas infectadas; com sintomas distintos e tratamento convergente no sentido de ser composto por múltiplas drogas. Para o desenrolar dessa pesquisa foram utilizados dados em domínio público, por meio do TabNet, disponíveis no Sistema de Informação de Agravos de Notificação, que foram então analisados. Os resultados deste estudo sugerem a eficácia de intervenções como o uso de rifampicina em dose única para profilaxia da hanseníase e as repercussões das medidas de controle da Covid-19 na redução temporária da incidência de tuberculose, com um aumento subsequente de casos em 2022. A análise também destaca a persistente desigualdade na distribuição dessas doenças, com maior acometimento de indivíduos do sexo. Fatores socioeconômicos, como baixos índices de escolaridade e renda, continuam a ser determinantes cruciais na alta incidência dessas doenças, reforçando a necessidade de políticas públicas que integrem ações de saúde e promoção social. Portanto políticas públicas são fundamentais para o enfrentamento dessas patologias.
PERSEPSYON NG MGA MAG-AARAL SA MAYORYANG FILIPINO HINGGIL SA ORAL NA PRESENTASYON: A CONVERGENT PARALLEL NA PAG-AARAL
Authors: Mary Ann C. Bangiban
Published: January 2025

Ang pag-aaral na ito ay gumamit ng mixed-method na disenyo upang suriin ang akademikong motibasyon ng mga mag-aaral. Partikular na ginamit ang convergent parallel mixed-method approach, na nagpapahintulot sa pagkolekta ng magkakaibang at komplemen ani (agatos u lilf arehong paksa. Sa kwanttatibong bahagi ng pag-aaral, 117 na mag-aaral ang sumagot, habang 14 na mag-aaral ang lumahok sa kwalitatibong bahagi. Ang mga resulta ay nagpakita na ang antas ng oral na presentasyon ng mga mag-aaral ay mataas, lalo na sa kanilang pag-aaral. Natukoy ang tatlong pangunahing tema kaugnay ng persepsyon sa oral na presentasyon sa mga mag-aaral ng kursong BSEd-Filipino: ang kahalagahan ng oral na presentasyon sa pag-aaral, ang oral na presentasyon ang siyang nagbibigay lakas sa mga mag-aaral, at ang kahalagahan ng pagbibigay suporta sa mga mag-aaral upang magpursige sa kanilang pag-aaral. Ang integrasyon ng mga datos mula sa kwantitatibo at kwalitatibong bahagi ay nagpakitang.convergence, kung saan ang mga natuklasan mula sa parehong uri ng datos ay nagbigay ng pare-parehong resulta at nagpatibay sa mga konklusyon ng pag-aaral.
MGA SUSING SALITA: mixed methods, persepsyon sa oral na presentasyon, Davao del Norte, Philippines
Síndrome de Edwards, un desafío clínico.
Authors: Camacho Delgadillo Humberto , Valdez Valeriano Andrea Paola
Published: January 2025

El síndrome de Edwards es un trastorno polimalformativo causado por la presencia de tres cromosomas en el par 18. Está relacionado con la edad materna avanzada y puede presentarse en toda la población, independientemente de raza o ubicación geográfica.
Este síndrome se caracteriza por múltiples malformaciones que afectan el crecimiento, así como por alteraciones craneofaciales, toracoabdominales, en las extremidades, la piel y faneras, además de anomalías neurológicas, cardíacas y pulmonares. Su pronóstico es reservado, con una alta mortalidad y un elevado riesgo de discapacidades graves.
En este informe presentamos un caso clínico basado en un diagnóstico clínico presuntivo, dado que no se disponía de técnicas de diagnóstico genético. El caso reúne la mayoría de las anomalías más frecuentes descritas para este síndrome, lo que permite sustentar el diagnóstico clínico.
Se destaca la importancia de la identificación prenatal de posibles anomalías clínicas mediante técnicas adecuadas, ya que estas permiten una mejor interpretación y manejo médico del caso, así como brindar apoyo emocional y orientación genética a la familia.
Sharp Szemerédi-Trotter Constructions in the Plane
Authors: Guth Larry , Silier Olivine
Published: January 2025

We present a new family of sharp examples for the Szemerédi-Trotter theorem. These are the first examples not based on a rectangular lattice. We also include an application to the discrete inverse Loomis-Whitney problem.
On the Asymptotic Behavior for Partitions Separated by Parity
Authors: Bringmann Kathrin , Craig William , Nazaroglu Caner
Published: January 2025

The study of partitions with parts separated by parity was initiated by Andrews in connection with Ramanujan’s mock theta functions, and his variations on this theme have produced generating functions with a large variety of different modular properties. In this paper, we use Ingham’s Tauberian theorem to compute the asymptotic main term for each of the eight functions studied by Andrews.
Counting Occurrences of Patterns in Permutations
Authors: Conway Andrew , Guttmann Anthony
Published: January 2025

We develop a new, powerful method for counting elements in a multiset. As a first application, we use this algorithm to study the number of occurrences of patterns in a permutation. For patterns of length 3 there are two Wilf classes, and the general behaviour of these is reasonably well-known. We slightly extend some of the known results in that case, and exhaustively study the case of patterns of length 4, about which there is little previous knowledge. For such patterns, there are seven Wilf classes, and based on extensive enumerations and careful series analysis, we have conjectured the asymptotic behaviour for all classes.
Pemberdayaan Masyarakat di Pedesaan melalui Program Pendidikan Islam Berkelanjutan
Authors: Hermansyah Yus , Rusnaya Mangun Rusnaya , Karim Mulkan , Sudrajat Cucu Jajat , Takiah Sofiatu , Hartini Yeyen
Published: January 2025

Program pengabdian kepada masyarakat ini bertujuan untuk memberdayakan masyarakat pedesaan melalui pendidikan Islam yang berkelanjutan. Dengan memanfaatkan potensi lokal dan memperkuat nilai-nilai keislaman, program ini berfokus pada peningkatan literasi agama, keterampilan hidup, dan kesadaran sosial melalui metode pengajaran yang kontekstual dan partisipatif. Kegiatan ini melibatkan pelatihan kepada guru-guru lokal, pengadaan materi ajar, serta pembentukan kelompok belajar berbasis masjid dan majelis taklim di wilayah Kecamatan Batununggal Kota Bandung. Hasil yang diharapkan dari program ini adalah peningkatan pemahaman masyarakat tentang ajaran Islam yang aplikatif dalam kehidupan sehari-hari, peningkatan partisipasi dalam kegiatan keagamaan dan sosial, serta terbentuknya kader-kader lokal yang mampu mengembangkan pendidikan Islam secara mandiri. Dengan demikian, program ini diharapkan dapat menjadi salah satu solusi dalam meningkatkan kesejahteraan masyarakat melalui pendidikan yang berkelanjutan.
Peningkatan Keterampilan Mengajar Guru-guru Pendidikan Agama Islam Melalui Workshop Metode Pembelajaran Aktif
Authors: Suhara Djenal , Suryatini Iis , Yudiyanto Mohamad , Kusmiati Elly , Zainuri Imam , Wahab Abdul
Published: January 2025

Pengabdian kepada masyarakat ini bertujuan untuk meningkatkan keterampilan mengajar guru-guru Pendidikan Agama Islam (PAI) melalui workshop metode pembelajaran aktif. Metode pembelajaran aktif dipilih karena mampu meningkatkan partisipasi dan pemahaman siswa dalam proses belajar mengajar. Kegiatan ini melibatkan sejumlah guru PAI dari berbagai sekolah di wilayah [nama wilayah]. Melalui workshop ini, para guru diberikan pelatihan intensif mengenai berbagai teknik dan strategi pembelajaran aktif yang dapat diterapkan dalam kelas. Hasil dari kegiatan menunjukkan peningkatan signifikan dalam kemampuan guru untuk merancang dan mengimplementasikan metode pembelajaran aktif. Diharapkan, peningkatan keterampilan ini akan berdampak positif terhadap kualitas pembelajaran PAI dan meningkatkan hasil belajar siswa.
Pengenalan Lean 7 Waste & Warehouse Management System Pada Manufacturing Kemasan Di Bandar Lampung
Authors: Setiawan Setiawan
Published: January 2025

Di Indonesia, kebutuhan akan kemasan, khususnya jenis PP Woven Bags dan FIBC, terus meningkat seiring dengan pertumbuhan industri dan perdagangan. Persaingan di sektor ini semakin ketat, memaksa perusahaan untuk terus beradaptasi dan menerapkan metode terbaik agar tetap bertahan dan unggul. Dalam menghadapi tantangan ini, pendekatan lean 7 waste dan penerapan warehouse management system (WMS) muncul sebagai solusi utama. Pendekatan lean 7 waste memfokuskan pada identifikasi dan pengurangan tujuh jenis pemborosan yang dapat mengganggu efisiensi operasional, yakni pemborosan waktu, bahan, tenaga kerja, inventaris, gerakan, proses, dan cacat produksi. Penerapan WMS, di sisi lain, bertujuan untuk meningkatkan pengelolaan inventaris dan aliran barang di gudang, sehingga mempercepat proses distribusi dan mengurangi biaya operasional. Dalam pengabdian ini karyawan dilatih untuk mampu mengidentifikasi pemborosan dan menerapkan perbaikan dengan menggunakan alat-alat lean seperti value stream mapping, 5S, dan kaizen. Metode penyampaian materi dilakukan dengan dua pendekatan, yaitu pemahaman teori dan pelaksanaan praktek di lapangan dengan cara mengidentifikasi aneka pemborosan dan melakukan perbaikan saat itu juga. Pengabdian ini menunjukkan bahwa pemahaman akan lean dan WMS kepada karyawan secara signifikan dapat meningkatkan daya saing perusahaan kemasan di Indonesia, memungkinkan mereka untuk beradaptasi dengan perubahan pasar dan tetap relevan dalam industri yang kompetitif ini.
The Impact of Tourism Development on Socio-Economic Conditions for Coastal Communities in Lasiana Beach, Kupang City
Authors: Ariawan I Wayan Adi Putra , Sanam Syul Rosli , Jehane Protasius Tiberius , Riwu Oktovianus Udju
Published: January 2025

Lasiana Beach is one of the tourist attractions that has become a prime destination due to its natural beauty, located in Lasiana Village, Kupang City. The tourism development at Lasiana Beach is supported by various stakeholders involved, such as the government, the local community, and academics who continuously research to promote sustainable tourism at Lasiana Beach. This is evidenced by data from the East Nusa Tenggara Provincial Tourism and Creative Economy Office, which indicates that the number of tourist visits to Lasiana Beach has consistently increased each year. The growth of tourism at this attraction presents opportunities for the surrounding coastal community to capitalize on the ongoing tourism development.  The challenges faced in the tourism development at the Lasiana Beach attraction include the lack of studies assessing the extent of the social and economic impacts on the coastal community of Lasiana Beach. Despite various efforts made by the local government to enhance tourism in the area, it remains unclear how far-reaching the resulting impacts have been. This research was conducted at Lasiana Beach in Kupang City using a qualitative descriptive method. The results of this study were analyzed based on indicators of socio-economic impact, such as the increase in community income, public health, population growth, labor absorption, and the development of the economic structure, which is characterized by economic activities arising from projects such as food stalls, restaurants, transportation services, shops, and others.
Taking time: Auditory statistical learning benefits from distributed exposure
Authors: de Waard Jasper , Theeuwes Jan , Bogaerts Louisa
Published: January 2025

In an auditory statistical learning paradigm, listeners learn to partition a continuous stream of syllables by discovering the repeating syllable patterns that constitute the speech stream. Here, we ask whether auditory statistical learning benefits from spaced exposure compared with massed exposure. In a longitudinal online study on Prolific, we exposed 100 participants to the regularities in a spaced way (i.e., with exposure blocks spread out over 3 days) and another 100 in a massed way (i.e., with all exposure blocks lumped together on a single day). In the exposure phase, participants listened to streams composed of pairs while responding to a target syllable. The spaced and massed groups exhibited equal learning during exposure, as indicated by a comparable response-time advantage for predictable target syllables. However, in terms of resulting long-term knowledge, we observed a benefit from spaced exposure. Following a 2-week delay period, we tested participants’ knowledge of the pairs in a forced-choice test. While both groups performed above chance, the spaced group had higher accuracy. Our findings speak to the importance of the timing of exposure to structured input and also for statistical learning outside of the laboratory (e.g., in language development), and imply that current investigations of auditory statistical learning likely underestimate human statistical learning abilities.
Hydrogen-bonded macrocycle-mediated dimerization for orthogonal supramolecular polymerization
Authors: Yu Wentao , Yang Zhiyao , Yu Chengkan , Li Xiaowei , Yuan Lihua
Published: January 2025

Orthogonal self-assembly represents a useful methodology to construct supramolecular polymers with AA- and AB-type monomers, as commonly used for covalently linked polymers. So far, the design of such monomers has relied heavily on three-dimensional macrocycles, and the use of two-dimensional shape-persistent macrocycles for this purpose remains rather rare. Here, we demonstrate a dimerization motif based on a hydrogen-bonded macrocycle that can be effectively applied to form orthogonal supramolecular polymers. The macrocycle-mediated connectivity was confirmed by single-crystal X-ray diﬀraction, which revealed a unique 2:2 binding motif between host and guest, bridged by two cationic pyridinium end groups through π-stacking interactions and other cooperative intermolecular forces. Zinc ion-induced coordination with the macrocycle and a terpyridinium derivative enabled orthogonal polymerization, as revealed by 1H NMR, DLS, and TEM techniques. In addition, viscosity measurements showed a transition from oligomers to polymers at the critical polymerization concentration of 17 μM. These polymers were highly concentration-dependent. Establishing this new dimerization motif with shape-persistent H-bonded macrocycles widens the scope of noncovalent building blocks for supramolecular polymers and augurs well for the future development of functional materials.
Significance of second-trimester uterine artery Doppler in predicting preeclampsia in South Indian pregnant women
Authors:   Department of Obstetrics and Gynaecology, Mid Yorkshire NHS Trust, West Yorkshire, UK, Jayaprakasam Prieyadharshini , Saraswathy Jeyaram Nadarajan ,   Department of Obstetrics and Gynaecology, Government Vellore Medical College, Vellore, India, Janifer Jasmine J. ,   Department of Research, General Hospital-Chennai, India
Published: January 2025

Aim. To evaluate the usefulness of uterine artery Doppler screening in second-trimester gestation women for predicting the risk of preeclampsia, and to identify the sensitivity and specificity of the Doppler indices-notching and pulsatility index (PI). Method. This study is a prospective, observational study involving 250 second-trimester pregnant women (20–24 weeks) in the Department of Antenatal Clinic, KGH Hospital (Tertiary Health Care Centre), Triplicane, and the Institute of Obstetrics and Gynaecology, Egmore, Chennai, India, from February 2019 to December 2022. After obtaining consent and meeting inclusion criteria, the study participants' gestational age, antenatal investigation, BMI, blood pressure, clinical markers, proteinuria, impaired uterine artery flow, uterine artery Doppler (UAD), and preeclampsia status were observed and recorded. Results. A total of 250 women between 20–24 weeks of gestation were included in this study. Doppler imaging was used to predict the risk of preeclampsia using notching and pulsatility index as diagnostic tools. Out of the 250 participants, 192 women had negative notching, whereas 58 women had positive notching. Among the 192 participants with negative notching, 94.8% were preeclampsia-free, 90.1% of the preeclampsia-free population fell within this group, and the total percentage of preeclampsia-free subjects was 72.8%. Among the 58 participants with positive notching, 34.5% were preeclampsia-free, while 9.9% had preeclampsia, accounting for a total percentage of 8.0%. Overall, preeclampsia was present in 100% of the cases with positive notching. The specificity was 0.90099 (95% CI: 0.84–0.93), the false negative rate was 0.052083 (95% CI: 0.02–0.09), and the false positive rate was 0.344828 (95% CI: 0.22–0.48), demonstrating a significant correlation between notching and preeclampsia (χ² = 104.433, p-value < 0.000). The aggregate proportion within PI among the 250 cases was 100.0%. Despite this, there was no significant association between PI and preeclampsia. Conclusion. Our study participants in the second trimester demonstrated a strong association between notching and preeclampsia. Notching during the second trimester showed a sensitivity of 79% (95% CI: 64–89%) and a specificity of 90% (95% CI: 84–93%). With a p-value < 0.000, the positive predictive value was 65%, and the negative predictive value was 94% (χ² = 104.433). Preeclampsia and PI were not significantly correlated. Doppler is an important tool for forecasting preeclampsia in high-risk second-trimester pregnancies.
Reported adverse effects of SARMs in animals and humans: A review
Authors:   Department of Physiology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgari, Vasilev Veselin , Boyadjiev Nikolay ,   Department of Physiology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria,   Research Institute, Medical University of Plovdiv, Plovdiv, Bulgaria
Published: January 2025

Background and objectives. Selective androgen receptor modulators (SARMs) are androgen receptor ligands that exhibit pronounced anabolic effects but demonstrate tissue selectivity regarding their androgenic effects. Despite the established beneficial effects of non-steroidal SARMs in several socially significant diseases, they also exhibit side effects. The purpose of this study was to present the currently reported adverse effects of SARMs in animals and humans. Clinical trials have been conducted with the non-steroidal group of modulators; however, in some cases, they were not sufficiently effective, and in others, the results have not yet been reported. To date, no non-steroidal SARM has been approved as a drug, but these substances are freely available on the Internet. Their frequency of use is increasing, which poses significant health risks. Materials and methods. To conduct this review, we identified and screened articles on SARMs using the Google Scholar, ScienceDirect, and PubMed electronic databases. Results. An increasing number of cases of liver damage due to the misuse of SARMs were reported during the period 2020–2024. In both humans and animals, non-steroidal SARMs frequently cause adverse changes in lipid profile indicators, as well as in gonadotropic and sex hormone concentrations. Cases of myocarditis, rhabdomyolysis, gynecomastia, and tendon rupture have been documented in amateur users of SARMs. Conclusion. In conclusion, SARMs are not safe, and measures must be taken to control and regulate their online trade. Additionally, greater efforts are needed to publicize information related to their side effects.
AVALIA-ULS: perceções dos médicos de família sobre recursos e formação
Authors: Gomes Juliana , Águas dos Santos Ana , Sequeira Leal Maria Inês , Mota Pimenta Filipa , Ornelas Azevedo Miguel , Antunes José Pedro , Macedo Rui , Chaves Beça Deolinda , Luz Pereira António
Published: January 2025

Enquadramento: o Grupo de Estudos de Gestão em Saúde (GEST) da Associação Portuguesa de Medicina Geral e Familiar (APMGF) elaborou o questionário “AVALIA-ULS: Análise das Vantagens e Limitações das Unidades Locais de Saúde (ULS) – Perspetivas da Medicina Geral e Familiar” para avaliar as perceções dos profissionais de Medicina Geral e Familiar (MGF) quanto à universalização deste modelo. O presente artigo constitui a segunda parte do estudo AVALIA-ULS, dedicando-se à análise das perspetivas acerca dos recursos e a organização da formação nas ULS. Objetivos: conhecer a perceção dos Médicos de Família sobre os recursos e a organização da formação nas ULS. Metodologia: aplicação de questionário online em 2023. Respostas analisadas através de Microsoft Excel® e SPSS®v. 27. Foi utilizado o teste qui-quadrado para análise entre subgrupos de profissionais com e sem experiência prévia em ULS (significância estatística para p<0.05). Resultados: obtiveram-se 342 respostas. Quanto à educação para a organização do sistema e a acessibilidade de recursos o impacto foi considerado mais negativo, enquanto para a organização formativa este foi considerado mais positivo com a transição para ULS. Conclusão: os resultados obtidos revelaram uma perceção globalmente negativa quanto à transição para o modelo de ULS.
Analisis Kesalahan Penggunaan Huruf Kapital dan Tanda Baca pada Paragraf Deskriptif Siswa Kelas V SD
Authors: Hothimah Ryani Husnul , Hasan Najib , Mawardi Mawardi
Published: January 2025

Pendidikan pada dasarnya merupakan hal yang sangat penting bagi kehidupan manusia. Dengan pendidikan manusia dapat mengembangkan potensi yang ada pada dirinya. Penelitian ini bertujuan untuk mengetahui kesalahan dan faktor yang menyebabkan penggunaan huruf kapital dan tanda baca pada paragraf deskriptif siswa kelas V SDN Cipondoh. Penelitian ini menggunakan metode penelitian kualitatif deskriptif, yaitu metode yang melibatkan peneliti secara langsung untuk mengamati fakta nyata yang ditemukan di lapangan. Subjek penelitian ini siswa kelas V dengan jumlah siswa yang diteliti sebanyak 34 siswa. Pengumpulan data dalam metode ini dilakukan dengan menggunakan instrumen  wawancara, tes dan dokumentasi. Hasil penelitian ini diperoleh hasil kesalahan  34 hasil tulisan paragraf siswa yang dianalisis, pada penggunaan huruf kapital kesalahan frekuensi terbesar yang paling banyak dilakukan siswa yaitu kesalahan penggunaan huruf kapital sebagai huruf pertama di awal kalimat, didapatkan 445 kesalahan dengan persentase 87% dengan kategori sangat tinggi, Sedangkan, penggunaan tanda baca dapat dilihat dari frekuensi kesalahan terbanyak yaitu pada penggunaan tanda baca titik yang memiliki 461 kesalahan dengan persentase 57,26%  dengan kategori tinggi dan frekuensi kesalahan terkecil yaitu pada penggunaan tanda baca seru yang memiliki 31 kesalahan dengan persentase 3,85% dengan kategori sangat rendah. Faktor yang menyebabkan siswa melakukan kesalahan dalam menggunakan huruf kapital dan tanda baca, yaitu disebabkan oleh daya pikir siswa rendah serta kebiasaan siswa yang lupa dan terburu-buru sehingga tidak menuliskan huruf kapital dan tanda baca secara terperinci yang membuat siswa ingin cepat selesai dalam menulis.
Peran Pendidikan dalam Mengurangi Stigma dan Diskriminasi terhadap Siswa dari Kelompok Minoritas Sosial
Authors: Harefa Anugerah Tatema , Lase Berkat Persada
Published: January 2025

Stigma dan diskriminasi terhadap siswa dari kelompok minoritas sosial di lingkungan sekolah dapat menghambat perkembangan akademis dan psikologis mereka, sehingga diperlukan pendekatan pendidikan yang inklusif untuk mengatasi masalah ini. Penelitian ini bertujuan untuk mengeksplorasi peran pendidikan dalam mengurangi stigma dan diskriminasi terhadap siswa dari kelompok minoritas sosial melalui metode studi literatur. Stigma dan diskriminasi di lingkungan sekolah dapat berdampak negatif pada perkembangan akademis dan psikologis siswa dari kelompok minoritas. Pendidikan inklusif, yang menekankan pengakuan dan penghargaan terhadap keragaman, dianggap sebagai salah satu strategi efektif untuk mengatasi masalah ini. Kurikulum yang berfokus pada keberagaman budaya, hak asasi manusia, dan anti-diskriminasi juga memiliki peran penting dalam membentuk pemahaman siswa tentang pentingnya menghormati perbedaan. Partisipasi aktif dari komunitas sekolah, termasuk siswa, orang tua, dan masyarakat luas, juga merupakan faktor penting dalam menciptakan budaya sekolah yang menghormati perbedaan dan menolak diskriminasi. Namun, tantangan dalam implementasi pendidikan inklusif, seperti kurangnya sumber daya dan resistensi dari sebagian pihak, perlu diatasi melalui upaya berkelanjutan. Hasil penelitian ini memberikan wawasan berharga bagi para pendidik, pembuat kebijakan, dan peneliti dalam upaya meningkatkan kualitas pendidikan dan keadilan sosial di sekolah-sekolah.
Meningkatkan Kecerdasan Emosioanal melalui Teknik Assertive pada Siswa Kelas 2 SMA
Authors: Ramadhan Ardiansyah , Ngayomi Sri , Hasibuan Fauzi , Saragih Mandra
Published: January 2025

Kecerdasan emosional merupakan kemampuan penting yang membantu individu mengelola emosi dan membangun hubungan interpersonal yang sehat. Upaya peningkatan kecerdasan emosional melalui teknik assertive dilakukan untuk membantu siswa kelas 2 dalam mengembangkan keterampilan komunikasi yang efektif dan mengurangi konflik sosial di lingkungan sekolah. Penelitian ini bertujuan Untuk meningkatkan kecerdasan emosional melalui teknik assertive pada siswa kelas 2 SMA Tarkeeyahtul Ummah School Thailand. Jenis penelitian ini adalah penelitian Eksperimen, dengan desain Pre Eksperimen (pretest - perlakuan- posttest). Hasil pre-test menunjukkan rata-rata subjek penelitian 85,5 memiliki tingkat kecerdasan emosional yang Low Average (dibawah rata-rata), dan hasil posttest menunjukkan rata-rata subjek penelitian 110 memiliki tingkat kecerdasan emosional yang Average ( rata-rata).Hasil analisis uji t untuk menguji perbedaan rata-rata data pretest dan posttest dk = 6, α = 0,05 di peroleh t (hitung) = 11, 9598 > t (table)= 1, 94318, disimpulkan ada perbedaan secara signifikan rata-rata skor pretes dengan Rata-rata skor postes. Hasil penelitian ini menunjukkan bahwa terdapat perbedaan yang signifikan antara tingkat kecerdasan emosional siswa sebelum dan sesudah diberikan teknik assertive training. Kesimpulan meningkatnya tingkat kecerdasan emosional siswa kelas 2 SMA Tarkeeyahtul Ummah school Thailand dari kategori Law Average menjadi kategori Average melalui kegiatan layanan teknik assertive.
Representation of the Expression of Ndebele Customary Law of Inheritance in Selected Educational Works in Zimbabwean Schools
Authors: Bhebe Cordial , Dube Bekithemba
Published: January 2025

The article examined the representation and the expression of the Ndebele Customary Law of Inheritance in selected educational works at the Ordinary Level in Zimbabwean schools. The study particularly explored the application of the traditional inheritance law as expressed in different educational works in the sphere of Literature. The analysis and discussion are derived from the Customary Law and from how inheritance issues are represented and handled in Ndebele educational works. The study further reflects on some of the problems recently encountered by how the custom is applied in the modernised era. In this regard, learners through cultural education would be guided accordingly on what the customary law of inheritance entails, have a better understanding of its modifications and changes in relation to the current socio-economic conditions of times and finally appreciate it as one of the critical customs in IsiNdebele traditional education. In conclusion, the study emphasises that the application of the inheritance system has been strongly affected by Modernisation, Formal Education and Christianity. The study contributed that in spite of these inevitable challenges, the custom should be dynamic and appreciative of modifications in accordance with the prevailing socio-economic changes of the times.

Keywords: Customary Law, Inheritance and Educational Works
Alignment Parameters: Quantifying Dense Core Alignment in Star-forming Regions
Authors: Chen Wei-An , Tang Ya-Wen , Clarke S. D. , Sanhueza Patricio
Published: January 2025

Recent high-resolution observations at millimeter (mm) and submillimeter wavelengths reveal a diverse spatial distribution for subparsec-scale dense cores within star-forming regions, ranging from clustered to aligned arrangements. To address the increasing volume of observational and simulation data, we introduce “alignment parameters” as a quantitative and reproducible method to automatically assess core alignment. We first demonstrate the effectiveness of these parameters by applying them to artificial test clumps and comparing the results with labels from visual inspection. A threshold value is then proposed to differentiate between “clustered” and “aligned” categories. Subsequently, we apply these parameters to dense cores identified from a sample of Atacama Large Millimeter/submillimeter Array 1.3 mm dust continuum images in high-mass star-forming regions. Analysis exploring correlations between alignment parameters and clump properties rules out the presence of a moderate or strong correlation, indicating that clump properties do not appear to strongly influence the outcome of fragmentation. One possible explanation for this is that the fragmentation process is chaotic, meaning that small variations in initial conditions can lead to significant differences in fragmentation outcomes, thus obscuring any direct link between clump properties and core alignment/distribution.
A cross-sectional study on the prevalence of multidrug-resistant clinical isolates of Proteus species in Northern Iran
Authors: Fallah Mahnaz Shafaei , Razavi Nikoo Hadi , Jamali Aylar , Mohebbi Alireza , Ghaemi Ezzat Allah
Published: January 2025

Introduction: Multidrug-resistant (MDR) bacteria like Proteus species have led to more prolonged hospitalizations, fewer care choices, higher treatment costs, and even death. The present study aims to evaluate the prevalence of MDR Proteus species in clinical samples and to suggest the best therapeutic options for the MDR Proteus species.
Methodology: Clinical samples were collected randomly from five hospitals in Golestan Province, Iran, from February 2017 to July 2019. Disk diffusion on Mueller–Hinton agar plates were used to perform antibiotic susceptibility testing (ASTs). By using a double-disc synergy test (DDST), isolates resistant to one of the third-generation cephalosporins were examined for phenotypic extended-spectrum β-lactamase (ESBL) development. A combined double disk synergy test (CDDST) was used to identify MBL-producing isolates.
Results: 61 Proteus isolates, including P. Mirabilis 44/61 (77.04%), P. vulgaris 7/61 (11.47%), P. hauseri 5/61 (8.19%), and P. penneri 2/61 (3.27%) were collected. Most of the isolates were obtained from urine samples. P. hauseri isolates were more frequent in females. Resistance to tetracycline and nitrofurantoin antibiotics was observed in most Proteus isolates. P. penneri isolates were all resistant to antibiotics. ESBL production was observed in five ceftazidime-resistant isolates (p < 0.05).
Conclusions: Cefepime and imipenem were found to have the lowest occurrence of antibiotic resistance among Proteus species, confirming that cefepime and imipenem can be used to treat Proteus infections.
Bilateral facial nerve palsy in a patient with West Nile neuroinvasive disease
Authors: Nikolić Nataša , Filipović Ana , Todorović Nevena , Jakšić Grgurović Mirjana , Mitrović Nikola , Malinić Jovan , Milošević Ivana
Published: January 2025

Introduction: Bilateral facial nerve palsy (FNP) is a rare condition that is idiopathic in only 20%. FNP is the most common cranial neuropathy in West Nile neuroinvasive disease (WNND) but is usually unilateral and only a few cases of bilateral FNP have been reported.
Case: We present a case of a 65-year-old woman with confirmed WNND and simultaneous bilateral FNP.
Results: In August 2022, the patient presented with ataxia, gait instability, tremor, fever, and vomiting. Following admission, due to her cerebrospinal fluid analyses she was diagnosed with WNV encephalitis. Her initial symptoms subsided, but on the 17th day of the disease, right FNP was observed. Three days later bilateral FNP developed, predominantly on the right side, with bilateral otalgia. Further diagnostic was performed but no other aetiology that could contribute to FNP was found. The patient was treated with a 3-day metilprednisolone course, followed by 60 mg of prednisone with dose tapering for 12 days. One month later she was discharged with significant regression of the left and slight regression of the right FNP. Subsequent physical therapy was conducted. The patient’s neurological status gradually improved and 4 months after the first symptoms onset, her neurological examination was normal.
Conclusions: WNND should be included in the differential diagnosis of acquired bilateral FNP. It can result in full recovery, but unfavorable course is also possible.