bluuebunny/crossref_metadata_2025 huggingface dataset:
Anatomical and Physiological responses of Citrus megaloxycarpa Lush.: A Cryptic Species of North-East India.
Authors: Jerang Arun , kumari Sony , Borthakur Madushmita , Ahmed Shahbaaz
Published: July 2021

In the historical mysteries and present pandemic situation, the use of citrus fruits makes it rise high among other fruits. Citrus has a significant role in dietary and medicinal purposes from time immemorial and widely acknowledged for its therapeutic properties. Citrus megaloxycarpa Lush. is an unspecified sibling of the citrus family. The present work highlights the use of the cryptic species of North-East India with its efficient biochemical, antimicrobial, anticancerous properties activity. The aim of this study was to characterize analyzed various biochemical, antioxidant, anticancerous parameters. The peel and pulp extract of ripening large citrus sample indicated as P(L1) and Pu(L2) respectively and unripe small peel and pulp extracts was indicated as P(S1) and Pu(S2) respectively. The extract of the Pu(L2) has the highest total soluble protein whereas the extract of P(L1) demonstrated high in carbohydrate concentration. On quantifying the free amino acid value, the extract of P(L2) showed higher in quantification. The total DPPH scavenging activity was compared for the extracts, where the extract of Pu(L2) exhibit high IC50 value. The present work concluded the use of Citrus megaloxycarpa Lush. peel and pulp extracts to be an efficient therapeutic drug.
Full Bagasse Bio-Waste Derived 3D Photothermal Aerogels for High Efficient Solar Steam Generation
Authors: Xiong Jun , Zhang Zhenning , Liu Yuhao , Yi Jie , Wang Yixin , Li Bowen , Wang Weiming , Peng Shuai , Min Xue , Gui Yunyun , Li Ming , Peng Junjun
Published: July 2021

Nowadays, freshwater shortage, energy crisis and environmental pollution are the three major threats to human beings. Herein, we develop a photothermal material based on bagasse for solar steam generation to relieve freshwater crisis and mitigate environmental pollution caused by bio-waste. The mainly functional part of the solar driven steam generator in this paper is bagasse-based photothermal aerogel (B-PTA), which composes of carbonized bagasse (CB) and bagasse-derived cellulose fiber (BDCF). The B-PTA with CB can effectively absorb solar (~95%) and has an excellent light-to-heat ability. The B-PTA with DBCF has super-hydrophilicity, water transport and retention ability. Depending on the excellent light absorption and 3D water passageway, the B-PTA gives a water evaporation rate of 1.36 kg m–2 h–1, and can achieve a photothermal conversion efficiency of 77.34% under 1-sun illumination (1 kW m–2). The B-PTA has excellent stability that the efficiency without significant decrease after 20 cycles. In addition, the B-PTA can effectively desalt seawater and purify dye wastewater with natural sunlight. Therefore, turning bio-waste into valuable photothermal material for solar steam generation is possible. Due to the merits of low cost, scalability, environmental friendliness, B-PTA has the potential for real-world water purification.
Effect of Probiotic, Prebiotic, or Synbiotic Supplement on Children, Adolescents, or Infants: A Protocol of an Umbrella Review
Authors: Fu Shunlian 付顺链 , Zhou Qian , Yuan Lijun , Li Zi-nan , Chen Qiu
Published: July 2021

Background: Many systematic reviews and meta-analyses have studied the association between probiotics, prebiotics, or synbiotics and children, adolescents, or Infants. With the promotion of probiotics, prebiotics, or synbiotics in our life and medical practice, more and more attention has been paid to them. Therefore, it is necessary to make a systematic summary of them. When the information was obtained in the identified systematic review, it will be compared with a control group that do not use probiotics, prebiotics, or synbiotics. In addition, our aim is to assess the quality of the included systematic reviews.Methods: We will conduct a comprehensive systematic search by summarizing systematic reviews of randomized controlled trials which have studied effect of probiotic, prebiotic, or synbiotic supplement on children, adolescents, or Infants. Four electronic databases (Embase, PubMed, Medline, and Cochrane Database of Systematic Reviews) will be searched. Two reviewers will independently screen the retrieved papers. Two reviewers will independently extract the data by reference to the JBI Data Extraction Form for Review for Systematic Reviews and Research Syntheses. We will also assess methodological quality and assessment of certainty in the findings by A Measurement Tool to Assess Systematic Review version 2 (AMSTAR-2) and the GRADE (Grading of Recommendations Assessment, Development and Evaluation). We will calculate the corrected covered area (CCA). We will recalculate the summary effect and 95% CIs by using fixed-effect or random-effect models.Discussion: Through quantitative and qualitative comparison by conducting an umbrella review, we hope our results will service better for future clinical practice.Systematic review registration: This protocol have finished the registration in the International Prospective Register of Systematic Reviews (PROSPERO) (registration number: CRD42021244923).
The Effect of Limbal Autograft Location at Primary Pterygium Excision on Anterior and Posterior Corneal Astigmatism: A Comparative Prospective Study
Authors: KAZANCI BURCU , Eroğlu Fatma Çorak , Şen Emine
Published: July 2021

Purpose: The aim of the study is to evaluate the effect of limbal autograft location on corneal astigmatism in inferior and superior conjunctival autografted pterygium surgery.Methods: Patients were divided into 2 groups as diagnosed with primary pterygium and planned to receive surgical treatment. Pterygium surgery was performed 25 patients with superior and 25 patients with inferior limbal autograft who have similar epidemiologic features. Cornea anterior and posterior surface keratometry (K) 1, K2, Kmax, peripheric radius (Rper) (the mean radius of curvature of the 7.0-9.0 mm ring area), refractive astigmatism and axis values, were examined. Corneal irregularity indices were the index of surface variance (ISV), index of vertical asymmetry (IVA, mm), index of height asymmetry (IHA, μm), index of height decentration (IHD, μm). The data were compared pre and postoperative and the effect of graft location on results was evaluated.Results: K1 which is from the values of the cornea front face has risen after surgery both of superior and inferior groups (p=0.011). However, no postoperative significant difference was detected in terms of the change. Otherwise, both of groups (p<0.001) have changed regarding astigmatism and Rper, but no postoperative significant difference was found in terms of the change. There were not any differences between groups regarding the changes of postoperative back face values. A significant decrease was detected on ISV, IVA, IHD values of the SLAG group (p<0.001) and ILAG group (p<0.001) in terms of all corneal anterior surface indices. However, there was no significant difference between the groups regarding the results of postoperative (p>0.05).Conclusion: The effects of pterygium surgery with limbal autograft were not significant on corneal astigmatism. However, we suggest that for the cases which need the protection of bulbar conjunctiva or when it can not be used, inferior bulbar conjunctiva preference can achieve successful results.
Breathers and Rogue Waves On The Double-Periodic Background for The Reverse-Space-Time Derivative Nonlinear Schrödinger Equation
Authors: Zhou Huijuan , Chen Yong
Published: July 2021

The dynamic behaviors of the solutions for the reverse-space-time derivative nonlinear Schrödinger equation are studied by Darboux transformation. The breathers on the periodic and double-periodic background are derived by the N -fold Darboux transformation. The rogue waves on the periodic and double-periodic background are constructed by the generalized Darboux transformation. It is worth mentioning that the breathers and rogue waves on double-periodic background based on the plane wave seed solution are first constructed. The two peak, four peak rogue waves on the double-periodic background are found. And the rogue waves on the double-periodic background can be transformed into the classical rogue wave on the plane wave background with a special reduction relation.
Altered Default Mode Network Is Associated With Cognitive Impairment in Cadasil as Revealed by Multimodal Neuroimaging
Authors: Li Panlong , Huang Qi , Ban Shiyu , Qiao Yuan , Wu Jing , Zhai Yu , Du Xiaoxia , Hua Fengchun , Su Jingjing
Published: July 2021

Background: Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) caused by mutations in NOTCH3 gene is a hereditary cerebral small vessel disease, manifesting with stroke, cognitive impairment and mood disturbances. Functional or structural changes in the default mode network (DMN), which plays important roles in cognitive and mental maintenance, have been found in a number of neurological and mental diseases. However, it is still unclear whether DMN is altered in CADASIL patients.Methods: Multimodal imaging methods, including magnetic resonance imaging (MRI) and positron emission tomography (PET), were applied to evaluate the functional, structural and metabolic characteristics of DMN in 25 CADASIL patients and 42 healthy controls.Results: Compared to controls, CADASIL patients had decreased nodal efficiency and degree centrality of the dorsal medial prefrontal cortex and hippocampal formation within DMN. Structural MRI and diffusion tensor imaging (DTI) showed decreased gray matter volume and fiber tracks presented in the bilateral hippocampal formation. Meanwhile, PET imaging showed decreased metabolism within the whole DMN in CADASIL. Furthermore, correlation analyses showed that these nodal characteristics, gray matter volume, and metabolic signals of DMN were related to cognitive scores in CADASIL.Conclusions: Our results suggested that altered network characteristics of DMN may play important roles in cognitive deficits of CADASIL.
Internal Flow Optimization in a Complex Profile Extrusion Die Using Flow Restrictors and Flow Separators
Authors: Xing Jingyang , Alsarheed Majed , Kundu Animesh , Coulter John P.
Published: July 2021

The control of flow balance at the die exit is the key for successful extrusion of polymers. The complex cross-sectional variation in real-world hollow extrusion profiles intrinsically promotes flow imbalance in the die cavity. Special considerations are required for designing extrusion dies for such profiles. The die design for a complex door frame profile was computationally optimized in this study with the aid of a commercially available software package. The velocity distribution at the die exit, post-die extrudate deformation, temperature distribution, and pressure distribution of a traditional die was investigated in detail and found to be inadequate. A modified die incorporated three distinct features, flow restrictors, flow separators and approach angle of the torpedoes, to achieve a balanced and uniform velocity at the die exit. The flow restrictors and flow separators were added in the pre-parallel zone. Flow restrictors were added on top and bottom of the torpedoes to increase the restriction on polymer flow. A unique inclined flow restrictor was introduced to achieve uniform internal melt flow. Flow separators were added at junctions of outer wall and inner vertical walls to separate the polymer flow into different sections and minimize cross flow between these sections. The addition of these features proved to be highly effective for balancing the velocity distribution at the die exit. The combination of 3-D modeling and simulation is an effective cost and time efficient approach for optimizing complex die designs before manufacturing.
Evaluation of Antibiotic Residue in Cow Milk and Its Impact on Danio Rerio
Authors: Chowdhury Jayanta , Mukherjee Riya , Dutta Debanjan , Mandal Tapan Kumar , Basu Tarakdas , Mondal Sandhimita
Published: July 2021

Ceftriaxone (CEFT), a widely used wide-spectrum beta -lactam cephalosporin antibiotic, is used to treat bovine mastitis, which is caused by a variety of bacteria. When this antibiotic is used injudiciously, it leaves a residue that persists after pasteurization. Antibiotic residue contamination occurs when antibiotic residue exceeds its Maximum Residue Limits (MRLs).This has a negative impact on both public health and the environment. The aim of a recent study was to determine the concentration of ceftriaxone residue (CEFTR) in raw and pasteurized mastitis cow milk, as well as its role in developmental toxicity and genotoxicity in zebra fish model. CEFTR concentrations in raw and pasteurized milk were several times higher than CEFT's MRL. CEFTR showed a decrease in body length and yolk sac region of zebra fish larvae 7-amino cephalosporanic acid (7-ACA), C3 and C7 are the cephalosporin constituents that produced by the breakdown of CEFT that may present in CEFTR, have an impact on the zebra fish embryo in this stage of development. Comet Assay or single cell gel electrophoresis (SCGE) also exhibited highest percentage of tail DNA, and tail moment that is the ultimate indicator of DNA damage by breaking DNA strands and incorporating guanine residue in the genome that ultimately damages DNA. As a result, the CEFTR is extremely concerning for public health and the environment. The toxic effects of the CEFTR in zebra fish model have not been studied yet. This is the first comprehensive study.
Clinical and Psychological Assessment of Patients With Rheumatoid Arthritis and Fibromyalgia
Authors: Gao Chao , Zhong Hua , Chen Lihong , Wang Li , Yao Hong , Huang Xiaowei , Jia Yubo , Li Chun , Liu Tian
Published: July 2021

ObjectiveThis study aimed to assess the clinical features as well as the functional and psychological status of patients with rheumatoid arthritis and fibromyalgia in a real-world setting in China.MethodsA total of 202 inpatients with rheumatoid arthritis from the Department of Rheumatology and Immunology at Peking University People’s Hospital were enrolled between December 2018 and April 2019. These inpatients were assessed for the presence of fibromyalgia using the 1990 American College of Rheumatology’s classification criteria for fibromyalgia. Disease activity and functional and psychological status were assessed using the Disease Activity Score in 28 Joints (DAS-28), Short Form-36 health survey questionnaire (SF-36), Health Assessment Questionnaire (HAQ), Hospital Anxiety and Depression Scale, and Visual Analog Scale.ResultsOf 202 patients with rheumatoid arthritis, 42 (20.8%) had concurrent fibromyalgia. Compared to patients without fibromyalgia, those with rheumatoid arthritis and fibromyalgia had higher DAS-28 scores (6.0 vs. 4.4, P=0.011) and notably higher tender joint counts (16.5 vs. 4.5, P<0.001). Patients with rheumatoid arthritis and fibromyalgia had worse HAQ scores (1.24 vs. 0.66, P<0.001) and lower SF-36 scores (28.6 vs. 58.2, P<0.001). Additionally, patients with rheumatoid arthritis and fibromyalgia experienced more fatigue (88.1% vs. 50.6%, P<0.001) and had higher anxiety (10 vs. 4, P<0.001) and depression scores (12 vs. 6, P<0.001). No significant differences in erythrocyte sedimentation rate, C-reactive protein concentration, morning stiffness period, or swollen joint counts were identified between the groups.ConclusionsPatients with rheumatoid arthritis and fibromyalgia had higher disease activity, worse functional and psychological status, and poorer quality of life. DAS-28 scores may have been overestimated in these patients. When patients with rheumatoid arthritis do not achieve remission, the possibility of fibromyalgia should be considered.
Evaluating Responsiveness of the Persian Version of the Western Ontario Meniscal Evaluation Tool (WOMET) in Iranian Patients with Meniscal Injury
Authors: Rad Zahra Jafari , Amiri Ali , Sohani Soheil Mansour
Published: July 2021

Background

This study aimed to evaluate the responsiveness of Western Ontario Meniscal Evaluation Tool (WOMET) and specify its Minimal Clinically Important Difference (MCID) in patients undergoing physiotherapy intervention following undergoing a meniscal lesion or surgery. Our hypothesis was that the WOMET would have adequate responsiveness in patients with meniscal injury.
method:

100 patients undergoing physiotherapy interventions filled the Persian version of the WOMET and a questionnaire of the Knee injury and Osteoarthritis Outcome Score (KOOS) at Session 1 and Session 10 (4 weeks later). They also filled the 7-point Global Rating of Change (GRC) scale at Session 10. Internal responsiveness was calculated using T test and effect sizes (standard response mean (SRM) and Cohen's d); and external responsiveness was calculated via receiver operating characteristic curve and correlation analysis. The inclusion criterion was the age of 18 to 70 years old for the patients who had the ability of filling the questionnaire. The exclusion criteria included ligaments injury, severe osteoarthritis, inability to complete the questionnaire due to the lack of sufficient knowledge, malignancy, infection, neuromusculoskeletal disorder, rheumatologic disease, knee surgeries for any other reasons, and dissatisfaction for being enrolled in the study.
Results

All the WOMET subscales (AUC = 0.7) had acceptable external responsiveness. SRM was Trivial, and the scores of Cohen’s d were moderate to large and t tests showed significant differences.
Conclusion

Our findings showed that all of the WOMET subscales had acceptable external responsiveness, and thus this questionnaire could be used to study the effects of physiotherapy interventions on patients undergoing a meniscal lesion or surgery.
A Stacking-based Ensemble Learning Method for Outlier Detection
Authors: Abro Abdul Ahad
Published: July 2021

Outlier detection is considered as one of the crucial research areas for data mining. Many methods have been studied widely and utilized for achieving better results in outlier detection from existing literature; however, the effects of these few ways are inadequate. In this paper, a stacking-based ensemble classifier has been proposed along with four base learners (namely, Rotation Forest, Random Forest, Bagging and Boosting) and a Meta-learner (namely, Logistic Regression) to progress the outlier detection performance. The proposedmechanism is evaluated on five datasets from the ODDS library by adopting five performance criteria. The experimental outcomes demonstrate that the proposed method outperforms than the conventional ensemble approaches concerning the accuracy, AUC (Area Under Curve), precision, recall and Fmeasure values.This method can be used for image recognition and machine learning problems, such as binary classification.
Bayesian Super-Resolution of Spectroscopic Data
Authors: Tsujimori Kota , Hirotani Jun , Harada Shunta
Published: July 2021

The resolution of spectroscopy, which delivers valuable insights and knowledge in various research fields, has sometimes been limited by the number of multi-channel detectors employed. For example, in Raman spectroscopy using charge coupled device (CCD) detectors, the resolution is limited by the number of the CCD arrays and it is difficult to achieve spectroscopic data acquisition with high resolution over a wide range. Here we describe a methodology to increase the resolution as well as signal-to-noise (S/N) ratio by applying Bayesian super-resolution in the analysis of spectroscopic data. In our present method, first the hyperparameters for the Bayesian super-resolution are determined by a virtual experiment imitating actual experimental data, and the precision of the super-resolution reconstruction is confirmed by the calculation of errors from the ideal values. For validation of the super-resolution of spectroscopic data, we applied this method to the analysis of Raman spectra. From 200 Raman spectra of a reference Si substrate with a resolution of about 0.8 cm− 1, super-resolution reconstruction with resolution of 0.01 cm− 1 was successfully achieved with the promised precision. From the super-resolution spectrum, the Raman scattering peak of the reference Si substrate was estimated as 520.55 (+ 0.12, -0.09) cm− 1, which is comparable to the precisely determined value from previous works. The present methodology can be applied to various kinds of spectroscopic analysis, leading to increased precision in the analysis of spectroscopic data and the ability to detect slight differences in spectral peak positions and shapes.
Testing behaviour and positivity for SARS-CoV-2 infection: Insights from web-based participatory surveillance
Authors: McDonald Scott A. , Soetens Loes , Schipper Maarten , Friesema Ingrid H. M. , Wijngaard Cees C. van den , Teirlinck Anne , Neppelenbroek Nienke , Hof Susan van den , Wallinga Jacco , Hoek Albert Jan van
Published: July 2021

BackgroundVoluntary testing for SARS-CoV-2 infection is an integral component of an effective response to the COVID-19 pandemic. It is essential to identify populations at a high risk for infection but who are less likely to present for testing. Here, we use internet-based participatory surveillance data from the Netherlands to identify sociodemographic and household factors that are associated with a lower propensity to be tested and, if tested, with a higher risk of a positive test result.MethodsMultivariable analyses using generalised estimating equations for binomial outcomes were conducted to estimate the adjusted odds ratios of testing and of positivity associated with participant and household characteristics.ResultsBased on five months (17 November 2020 to 18 April 2021) of weekly surveys obtained from 12,026 participants, males (adjusted odds ratio for testing (ORt): 0.92; adjusted odds ratio for positivity (ORp): 1.30, age-groups <20 (ORt: 0.89; ORp: 1.27) 50-64 years (ORt: 0.94; ORp: 1.06) and 65+ years (ORt: 0.78; ORp: 1.24), diabetics (ORt: 0.97; ORp: 1.06), and sales/administrative employees (ORt: 0.93; ORp: 1.90) were distinguished as lower propensity/higher positivity factors.ConclusionsThe factors identified using this approach can help identify potential target groups for improving communication and encouraging testing among those with symptoms and thus increase the effectiveness of testing, which is essential for the response to the COVID-19 pandemic and for public health strategies in the longer term.
Lidocaine inhibited migration of NSCLCA549 cells via the CXCR4 regulation
Authors: Xing Baichun , Yang Linlin , Cui Yanan
Published: July 2021

Background
Lidocaine is a local anesthetic that wildly used in surgical treatment and postoperative medical care for lung cancers. We hypothesized that lidocaine at clinical plasma concentration can inhibit CXCL12/CXCR4 axis-regulated cytoskeletal remodeling thereby reduce the migration of Non-small-cell lung cancers (NSCLC) cells.
Methods
We determined the effect of lidocaine at clinical plasma concentration on CXCL12-induced cell viability, apoptosis, cell death, monolayer cell wound healing rate, individual cell migration indicators, expression of CXCR4, CD44, and ICAM-1, intracellular Ca2+ level, and filamentous actin level alteration of NSCLC cells A549 and CXCR4-knocked down A549 cells using CCK-8, Bcl-2 ELISA, Cell death ELISA, wound healing assay, chemotaxis assay, western blotting, QPCR, Fura-2-based intracellular Ca2+ assay, and Fluorescein Phalloidin staining respectively.
Results
Lidocaine did not affect cell viability, apoptosis, and cell death but inhibited CXCL12-induced migration, intracellular Ca2+ releasing, and filamentous actin increase. Lidocaine decreased expression of CXCR4, increased CD44, but had no effect on ICAM-1. CXCL12 induced the increase of CD44 and ICAM-1 but did not affect CD44 in the presence of lidocaine. The knockdown of CXCR4 eliminated all the effects of lidocaine. The overexpression of CXCR4 promoted migration but the migration was inhibited by lidocaine.
Conclusion
Lidocaine at clinical plasma concentrations inhibited CXCL12-induced CXCR4 activation, thereby reduced the intracellular Ca2+-dependent cytoskeleton remodeling, resulting in slower migration of A549 cells.
The non-fatal burden of cancer in Belgium, 2004–2018
Authors: Gorasso Vanessa , Silversmit Geert , Arbyn Marc , Cornez Astrid , De Pauw Robby , De Smedt Delphine , Grant Ian , Wyper Grant M.A. , Devleesschauwer Brecht , Speybroeck Niko
Published: July 2021

Background

The importance of assessing and monitoring the health status of a population has grown in the last decades. Consistent and high quality data on the morbidity and mortality impact of a disease represent the key element for this assessment. Being increasingly used in global and national burden of diseases (BoD) studies, the Disability-Adjusted Life Year (DALY) is an indicator that combines healthy life years lost due to living with disease (Years Lived with Disability; YLD) and due to dying prematurely (Years of Life Lost; YLL). As a step towards a comprehensive national burden of disease study, this study aims to estimate the non-fatal burden of cancer in Belgium using national data.
Methods

We estimated the Belgian cancer burden from 2004 to 2018 in terms of YLD, using national population-based cancer registry data and international disease models. We developed a microsimulation model to translate incidence- into prevalence-based estimates, and used expert elicitation to integrate the long-term impact of increased disability due to surgical treatment.
Results

The age-standardized non-fatal burden of cancer increased from 2004 to 2018 by 6% and 2% respectively for incidence- and prevalence-based YLDs. In 2018, in Belgium, breast cancer had the highest morbidity impact among women, followed by colorectal and non-melanoma skin cancer. Among men, prostate cancer had the highest morbidity impact, followed by colorectal and non-melanoma skin cancer. Between 2004 and 2018, non-melanoma skin cancer significantly increased for both sexes in terms of age-standardized incidence-based YLD per 100,000, from 48 to 107 for men and from 15 to 37 for women. Important decreases were seen for colorectal cancer for both sexes in terms of age-standardized incidence-based YLD per 100,000, from 104 to 85 for men and from 52 to 46 for women.
Conclusions

Breast and prostate cancers represent the greatest proportion of cancer morbidity, while for both sexes the morbidity burden of skin cancer has shown an important increase from 2004 onwards. Integrating the current study in the Belgian national burden of disease study will allow monitoring of the burden of cancer over time, highlighting new trends and assessing the impact of public health policies.
Commercialization of intellectual property: innovative impact on global competitiveness of national economies
Authors: Virchenko Volodymyr , Petrunia Yurii , Osetskyi Valerii , Makarenko Mykhaylo , Sheludko Valentyna
Published: July 2021

This paper investigates the role of intellectual property in the modern post-industrial economy and its intensive commercialization of the country's competitive advantages in the global economic environment. The main purpose of the research is to prove the hypothesis about the crucial role of intellectual property development in ensuring expanded public reproduction and facilitating the global competitiveness of national economies through innovative modernization of production. To gain the research aim, the authors used a combination of theoretical synthesis and comprehensive statistical analysis. The study follows a deductive approach and theoretical background analysis followed by quantitative research of statistical data. It allowed arriving essential conclusions concerning the role of intellectual property in strengthening the global competitiveness of the national economy and practical policy implications regarding stimulating intellectual property commercialization within the national economy. Paper investigates transmission mechanisms that represent the impact of intensive commercialization of intellectual property on public reproduction and competitiveness of the national economy. Commercialization of intellectual property, defined as a range of activities envisaged for rapid implementation of intellectual activity, resulted in economic turnover to obtain strategic competitive advantages and generate economic profit supported by the transformation of intellectual property into intellectual capital used for the manufacturing of innovative, highly marginal products. Comprehensive statistical data analysis was conducted using quantitative methods (cluster analysis and principal components analysis). The findings proved the key role of intellectual property in the modern system of public reproduction. They demonstrated the multiplicative impact of intellectual property development on a country's competitive global economic environment. Obtained research results provided the basis for policy implications concerning the development of commercialization of intellectual property and stimulation of expanded reproduction of intellectual capital in Ukraine as a precondition of innovative modernization of national industries and acquiring strategic competitive advantages in a globalized market.
Marketing and management of innovations in public governance as core determinants of trust
Authors: Vysochyna Alina , Semenov Volodymyr , Kyrychenko Kostiantyn
Published: July 2021

Public governance significantly transformed over the last several decades that is determined by numerous external and internal factors. Digitalization of social and economic relations results in the appearance and implementation of a new kind of innovation in public management – e-governance. Therefore, developing the marketing and management strategy of such innovation as e-governance is considered a necessary precondition for trust in government. The paper aims to determine the impact of e-governance on trust in government and the development of recommendations on marketing and management of it. In the paper, the authors systematized main national and foreign approaches to measuring e-governance efficiency both at the level of central and sub-central governments. It is also realized a bibliometric analysis with VOSviewer v.1.6.16 to identify key contextual directions of scientific research on e-governance, marketing, and management and clarify its intercepts. The paper has developed a scientific hypothesis about the positive influence of e-governance on central and sub-central government brands and citizens' loyalty. To test this hypothesis, a panel data regression analysis was realized using Stata 12/SE software. In the regression model as a proxy of e-governance efficiency (independent variable), an E-Government Development Index (EGDI) is chosen, which is a composite indicator of three indices such as online service index, telecommunication index, and human capital index. It is chosen as a proxy central and sub-central government brand and citizens' loyalty (dependent variable), an indicator of Trust in Government that is calculated by the Organisation for Economic Co-operation and Development (OECD) and refers to the share of people who report having confidence in the national government. Besides, the regression model includes a sample of control variables such as Worldwide Governance Indicators. The country sample consists of 19 OECD member states (European countries): Austria, Belgium, Czech Republic, Denmark, Finland, France, Greece, Hungary, Italy, The Netherlands, Poland, Portugal, Slovak Republic, Sweden, Great Britain, Estonia, Latvia, Lithuania, and Slovenia. 2008-2020 (specifically, 2008, 2010, 2012, 2014, 2016, 2018, 2020). Under the bibliometric and regression analysis results, a set of practical recommendations on the perspectives of central and sub-central governments' marketing and management of e-governance
Genetic Analysis of Mitochondrial Sorting from the MSC3 Mosaic Mutant of Cucumber
Authors: Wallace Lyle T. , Havey Michael J.
Published: July 2021

Cucumber (Cucumis sativus) plants regenerated from cell cultures occasionally possess mosaic (MSC) phenotypes on cotyledons and leaves. Lines MSC3 and MSC16 have distinct MSC phenotypes and originated from plants regenerated from different cell-culture experiments established using a highly inbred wild-type cucumber. Both the mitochondrial (mt) DNA and MSC phenotype of cucumber show paternal transmission, and MSC3 and MSC16 have different mt coding regions at significantly lower copy numbers relative to wild-type plants. A nuclear locus, Paternal sorting of mitochondria (Psm), conditions a high proportion of wild-type progenies, specifically when MSC16 is crossed as the male with wild-type female plants. During this research, we identified plants that produced a high proportion of wild-type progenies in crosses with MSC3 as the male parent. Plants from an F2 family were crossed with MSC3 as the male, progenies were scored for numbers of MSC vs. wild-type plants, and single-nucleotide polymorphisms (SNP) were identified for genetic mapping. A major quantitative trait locus on chromosome 3 was associated with a higher frequency of wild-type progenies from MSC3 as the male parent, and the 1.5-logarithm-of-odds interval for the most significant SNP was located 627 kb from Psm. These results reveal that separate genetic factors control sorting to the wild-type phenotype in progenies from crosses with different MSC parents. The identification of causal genes controlling mitochondrial sorting in cucumber should provide insight regarding nuclear-mitochondrial interactions affecting the prevalence of specific mitochondrial DNA in plants.
The Clinicopathologic Evaluation of Eosinophilic Cholecystitis: A Retrospective Observational Study in a Tertiary Care Center
Authors: Erdogan-Durmus Senay , Balta Hilal , Ozmen Sevilay , Calik Ilknur , Can Yusuf , Kurt Ali
Published: July 2021

Background: Eosinophilic cholecystitis (EC) is a rare form of cholecystitis that is diagnosed histopathologically. The aim of this study to evaluate the patient demographic features, laboratory findings and histopathologic characteristics of EC. The aim of this study to evaluate the patient demographic features, laboratory findings and histopathologic characteristics of EC.

Design and setting: Retrospective observational study conducted in Erzurum, Turkey.

Methods: Between June 2014 and June 2017 3,178 cholecystectomy specimens were reviewed retrospectively. Nineteen EC cases were included to the study. Parameters such as sex, age, clinical information, laboratory findings were obtained from information system of hospital. And the data of EC group were compared with a control group of 50 non-specific chronic cholecystitis patients (CC).

Result: Out of 3,178 cholecystectomy specimens, 19 cases were diagnosed as EC (0.59%). Patients’ age ranged from 22-84 years and female to male ratio was 1.7:1. The average eosinophil count was 139.7 U/L in EC group. 11.7% of EC group had high level for eosinophils. In the EC group there were statistical significances between high eosinophil percentages and aspartate transaminase (AST), alkaline phosphatase (ALP) values (P<0.05, P<0.05). The EC group eosinophil levels were slightly higher than CC. Histopathologically, dense, severe infiltrates composed of eosinophils were seen.

Conclusion: EC is a rare entity that can only diagnosed by histopathology.  There were certain high levels in liver function tests and eosinophils in correlation with non-specific cholecystitis. Although the presentation may be similar to non-specific cholecystitis, if a postoperative histopathological diagnosis of EC is made, then the patient must be investigated thoroughly to rule out other associated disease conditions.
Gravitational waves from an axion-dark photon system: A lattice study
Authors: Ratzinger Wolfram , Schwaller Pedro , Stefanek Benjamin
Published: July 2021

In this work, we present a lattice study of an axion - dark photon
system in the early Universe and show that the stochastic gravitational
wave (GW) background produced by this system may be probed by future GW
experiments across a vast range of frequencies. The numerical simulation
on the lattice allows us to take into account non-linear backreaction
effects and enables us to accurately predict the final relic abundance
of the axion or axion-like particle (ALP) as well as its
inhomogeneities, and gives a more precise prediction of the GW spectrum.
Importantly, we find that the GW spectrum has more power at high momenta
due to 2\rightarrow12→1
processes. Furthermore, we find the degree of polarization of the peak
of the GW spectrum depends on the ALP-dark photon coupling and that the
polarization can be washed out or even flipped for large values thereof.
In line with recent results in the literature, we find the ALP relic
abundance may be suppressed by two orders of magnitude and discuss
possible extensions of the model that expand the viable parameter space.
Finally, we discuss the possibility to probe ultralight ALP dark matter
via spectral distortions of the CMB.
O USO DA ROBÓTICA NO ENSINO DE LÓGICA COMPUTACIONAL: UMA PROPOSTA PARA AS SÉRIES INICIAIS
Authors: Pizzi Zilli Jaqueline , Brandão Pasinato Larissa , Sandini Trentin Marco Antônio
Published: July 2021

A Internet das Coisas é uma forte tendência na sociedade contemporânea e tecnológica. Diante disso, o conhecimento de conceitos em computação torna-se requisito para habilitar cidadãos ao contexto da sociedade da informação. O estímulo ao raciocínio lógico-abstrato e a resolução de problemas através da abordagem do Pensamento Computacional são caminhos essenciais para alcançar tal objetivo. Sendo assim, o presente trabalho descreve uma pesquisa que confeccionou um dispositivo robótico e desenvolveu um aplicativo utilizando-se do microcontrolador Arduino e do software AppInventor, associados a uma sequência didática para introduzir conceitos do Pensamento Computacional. O objetivo principal da utilização dos dispositivos era verificar seus desdobramentos junto a crianças em idade de alfabetização, ao adotar a robótica educativa por meio de dispositivos móveis. Durante sua realização, pode-se observar indícios de que as crianças participantes conseguiram lidar razoavelmente com questões abstratas a partir das atividades propostas neste trabalho. Também se conclui que ações como essa demonstram ser possível a inserção do Pensamento Computacional consorciado com atividades lúdicas desde os primeiros anos escolares.
METODOLOGIAS PARA O ENSINO DE PROGRAMAÇÃO INTRODUTÓRIA: UM ESTUDO COM PROFESSORES NUMA UNIVERSIDADE BRASILEIRA
Authors: Izeki Claudia Akemi , Seraphim Enzo , Flores Maria Assunção
Published: July 2021

Este artigo baseia-se em um projeto de investigação mais alargado e tem por objetivo estudar as práticas docentes em uma universidade brasileira no que concerne à metodologia de ensino na Programação Introdutória, nomeadamente os métodos de ensino, a lógica de organização das atividades e a percepção docente quanto ao envolvimento dos estudantes nas aulas. Constitui-se em um tema relevante no contexto do Ensino Superior na medida que entender essas práticas ajudará a promover reflexões e mudanças para um processo de ensino-aprendizagem mais eficaz. Os dados foram recolhidos de entrevistas individuais semiestruturadas a docentes de uma universidade brasileira a respeito de seus planejamentos e práticas em sala de aula. Concluiu-se que a lógica dominante de ensino desses professores é bastante tradicional, sobressaindo-se o método magistral, tendo como organização das atividades a explicação de conteúdo seguida de exemplos e atividades práticas, principalmente exercícios, com variações no tempo e no espaço. Apesar da maioria dos docentes relatar um bom envolvimento dos estudantes nas aulas, há uma limitada variedade de tarefas ofertada aos estudantes. Nesse ínterim, uma competência docente essencial é possuir o conhecimento de vários métodos e estratégias para um ensino mais eficaz, o que subjaz uma ressignificação da identidade profissional docente.
O PENSAMENTO COMPUTACIONAL NO ENSINO FUNDAMENTAL I: SABERES ARTICULADOS ENTRE COMPUTAÇÃO E ARTES VISUAIS
Authors: Alves Pietro Matheus Bompet Fontoura , De Morais Pauleany Simões , Alves Rejane de Oliveira
Published: July 2021

O presente artigo investiga as potencialidades do ensino de Computação, com ênfase ao Pensamento Computacional, articulado com Artes Visuais no Ensino Fundamental I. A atividade foi resultante do Estágio Supervisionado da Licenciatura em Computação, tendo a pesquisa-ação como metodologia norteadora e a Computação Desplugada como o conjunto de técnicas que possibilitaram as ações no contexto de uma escola pública de Salvador/BA. Os resultados a necessidade da presença da Computação na escola, especialmente articulada com os componentes curriculares já existentes; além de demonstrar que é possível desenvolver ações envolvendo o Pensamento Computacional articulado com outras áreas do conhecimento, para além das Ciências Exatas.
PENSAMENTO COMPUTACIONAL NA FORMAÇÃO INICIAL DE PROFESSORES DE MATEMÁTICA: UM ESTUDO DE CASO SOB A PERSPECTIVA DA TEORIA DE ROBBIE CASE
Authors: Canal Ana Paula , Bisognin Vanilde , Isaia Silvia Maria de Aguiar
Published: July 2021

O Pensamento Computacional tem sido inserido no ensino como um componente curricular específico da Computação ou em conjunto a outros componentes curriculares. Há necessidade de desenvolver as habilidades do Pensamento Computacional nos estudantes e, consequentemente, nos professores. Como forma de inserir o Pensamento Computacional, com o componente curricular da Matemática, este artigo traz um estudo de caso realizado com os licenciandos em Matemática, em uma universidade privada. Para tal, foi ofertada uma disciplina extracurricular, trabalhando o conteúdo de padrões e regularidades, com o Pensamento Computacional, por meio da linguagem de programação Python. A pesquisa é qualitativa, do tipo estudo de caso em que foram analisadas duas atividades desenvolvidas pelos licenciandos, sob a perspectiva da teoria neopiagetiana de Robbie Case. Com a investigação, identificaram-se as relações entre o Pensamento Computacional e o Pensamento Algébrico e foi proposto um caminho para inclusão do Pensamento Computacional no ensino, para formação inicial de professores de Matemática.
MEME DE OSWALDO CRUZ COMO ESTRATÉGIA DE ENSINO SOBRE FEBRE AMARELA E A IMPORTÂNCIA DA VACINAÇÃO
Authors: Frey Daniela , Alves-de-Oliveira Maria de Fátima , Barros Marcelo Diniz Monteiro de
Published: July 2021

A febre amarela é uma doença grave, prevenida de forma eficiente pela vacinação. Entre 2017 e 2018, o país teve um considerável aumento do número de casos da forma silvestre e de mortes dela decorrentes, especialmente em áreas que não eram consideradas de risco. Nossa proposta foi utilizar, para ir à contramão das fake news que estimulam a não vacinação, um meme com a imagem de Oswaldo Cruz, como desencadeador, em aulas de Biologia de um Curso Técnico em Telecomunicações Integrado ao Ensino Médio de uma instituição pública, em Petrópolis (RJ), de discussões sobre febre amarela e sua profilaxia, levando a 100% da cobertura vacinal entre esses alunos. Questões de saúde pública, como essa, podem e devem ser levadas para a sala de aula, não apenas de Biologia, mas de forma multidisciplinar, promovendo debates e contribuindo para um movimento de divulgação científica, assim como para a profilaxia desta e de outras doenças.
AMORISMO: A CONSTRUÇÃO DE UM ÍNDICE EMOCIONAL ATRAVÉS DO MAPEAMENTO SOCIOEMOCIONAL
Authors: Decarli Cecilia , Fraga Cristiano da Cruz , Carmo Juliano Santos do
Published: July 2021

Este artigo tem por objetivo analisar a importância do diagnóstico socioemocional para compreensão de comportamentos e processos de desenvolvimento e aprendizagem de alunos do ensino fundamental. A construção do índice emocional ocorreu mediante o mapeamento socioemocional obtido por meio de oficinas de afetividade ministradas para 63 alunos de 7°s anos do Ensino Fundamental de uma escola pública do município de Campo Bom-RS. O índice foi elaborado a partir de uma abordagem quali-quantitativa (mista) de pesquisa, mediante os resultados obtidos nas oficinas aplicadas, considerando a importância da concepção do amorismo para o ensino, através da educação socioemocional no ensino básico. Foram obtidos como resultados do índice emocional: 5 alunos com conceito muito bom, 50 com conceito bom e 8 com conceito ruim. Os dados advindos da aplicação do índice emocional aqui proposto poderão ser úteis para estabelecer um novo olhar aos alunos envolvidos que, por ventura, apresentarem lacunas de cunho social e emocional. Dessa forma, os professores terão acesso aos perfis individuais e poderão potencializar o processo de ensino aprendizagem através de práticas pedagógicas que abordem as competências afetivas e socioemocionais. O índice emocional apresentado neste estudo pode ser replicado a outros contextos e realidades educacionais tornando-se um método de aplicação no ensino.
 
Palavras-chave: Amorismo. Oficinas de afetividade. Ensino Fundamental. Índice emocional.
O SISTEMA EDUCACIONAL INTERATIVO E AS PERSPECTIVAS DE FORMAÇÃO HUMANA DOS ALUNOS DO ENSINO MÉDIO DAS COMUNIDADES RURAIS DO ESTADO DO PARÁ
Authors: Matos Cleide Carvalho , Dos Reis Manuelle Espindola , Couto Jeovani de Jesus
Published: July 2021

Este artigo tem como objetivo analisar as perspectivas de formação humana presentes na proposta de educação implementada por meio do Sistema Educacional Interativo no Pará. A pesquisa foi realizada por meio de pesquisa bibliográfica e documental. Os principais teóricos que fundamentam a análise são: Frigotto (2010), Saviani (2013, 1982), Kosic (2011), Fereira (2015), Angeli (2009). O Sistema Educacional Interativo além de não potencializar a formação humana, aprofunda ainda mais as desigualdades sociais e regionais ao promover uma política educacional dualista urbano/rural, fragmentada e com qualidade duvidosa, pouco efetiva no desenvolvimento da formação omnilateral das populações que historicamente tiverem negado seu direito, ao acesso dos conhecimento produzidos pela humanidade. A metodologia de ensino utilizada para acesso ao ensino médio das comunidades rurais, por meio do Sistema Educacional Interativo, pouco contribuirá para a reflexão da realidade concreta desses sujeitos e consequentemente para sua transformação.
PENSAMENTO CRÍTICO NA CIÊNCIA: PERSPECTIVA DOS LIVROS DIDÁTICOS BRASILEIROS
Authors: Corrêa de Mattos Kélli Renata , Güllich Roque Ismael da Costa , Tolentino Neto Luiz Caldeira Brant de
Published: July 2021

A educação em Ciências precisa subsidiar os sujeitos contemporâneos com uma formação que não priorize somente os conhecimentos científicos, mas também o desenvolvimento de competências para que atuem em sociedade. Nesse contexto, considera-se a promoção do Pensamento Crítico (PC) como uma abordagem em potencial. Pensando nisso, realizou-se uma análise documental em 8 Livros Didáticos (LD) do 7º ano do Ensino Fundamental, identificando a natureza das atividades propostas, bem como o potencial das mesmas para o desenvolvimento das capacidades do PC. Percebe-se, com a análise a diversidade de atividades presentes nos LD de Ciências, sendo que as mais recorrentes foram classificadas na categoria Exploratórias, as quais conferem a oportunidade do sujeito se envolver no processo, a depender do encaminhamento pedagógico. Observa-se também, a presença de atividades classificadas como Reflexivas/Críticas, as quais desempenham um papel crucial na formação do sujeito, instigando-o a pensar, refletir e criticar. Verifica-se ainda, a presença de atividades mais tradicionais classificadas na categoria Informativas, pois apenas têm o intuito de apresentar uma informação adicional ao conteúdo. Contudo, considera-se os resultados satisfatórios, pois expressam que os LD de Ciências, não possuem predominantemente atividades simplistas e tradicionais, mas que tem avançado em relação ao caráter das atividades propostas.