bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure S8 from The Neo-Open Reading Frame Peptides That Comprise the Tumor Framome Are a Rich Source of Neoantigens for Cancer Immunotherapy
Authors: Martin Michael V. , Aguilar-Rosas Salvador , Franke Katka , Pieterse Mark , Langelaar Jamie van , Schreurs Renée , Bijlsma Maarten F. , Besselink Marc G. , Koster Jan , Timens Wim , Khasraw Mustafa , Ashley David M. , Keir Stephen T. , Ottensmeier Christian H. , King Emma V. , Verheij Joanne , Waasdorp Cynthia , Valk Peter J.M. , Engels Sem A.G. , Oostenbach Ellen , van Dinter Jip T. , Hofman Damon A. , Mok Juk Yee , van Esch Wim J.E. , Wilmink Hanneke , Monkhorst Kim , Verheul Henk M.W. , Poel Dennis , Hiltermann T. Jeroen N. , Kempen Léon C.L.T. van , Groen Harry J.M. , Aerts Joachim G.J.V. , Heesch Sebastiaan van , Löwenberg Bob , Plasterk Ronald , Kloosterman Wigard P.
Published: June 2024

Figure S8: Comparison of EasyFuse short-read fusion gene caller with long-read and WGS guided NOP identification.
Figure S12 from The Neo-Open Reading Frame Peptides That Comprise the Tumor Framome Are a Rich Source of Neoantigens for Cancer Immunotherapy
Authors: Martin Michael V. , Aguilar-Rosas Salvador , Franke Katka , Pieterse Mark , Langelaar Jamie van , Schreurs Renée , Bijlsma Maarten F. , Besselink Marc G. , Koster Jan , Timens Wim , Khasraw Mustafa , Ashley David M. , Keir Stephen T. , Ottensmeier Christian H. , King Emma V. , Verheij Joanne , Waasdorp Cynthia , Valk Peter J.M. , Engels Sem A.G. , Oostenbach Ellen , van Dinter Jip T. , Hofman Damon A. , Mok Juk Yee , van Esch Wim J.E. , Wilmink Hanneke , Monkhorst Kim , Verheul Henk M.W. , Poel Dennis , Hiltermann T. Jeroen N. , Kempen Léon C.L.T. van , Groen Harry J.M. , Aerts Joachim G.J.V. , Heesch Sebastiaan van , Löwenberg Bob , Plasterk Ronald , Kloosterman Wigard P.
Published: June 2024

Figure S12: Example of a genomic rearrangement resulting in the expression of multiple hidden NOPs in tumor sample BRE007.
Figure S11 from The Neo-Open Reading Frame Peptides That Comprise the Tumor Framome Are a Rich Source of Neoantigens for Cancer Immunotherapy
Authors: Martin Michael V. , Aguilar-Rosas Salvador , Franke Katka , Pieterse Mark , Langelaar Jamie van , Schreurs Renée , Bijlsma Maarten F. , Besselink Marc G. , Koster Jan , Timens Wim , Khasraw Mustafa , Ashley David M. , Keir Stephen T. , Ottensmeier Christian H. , King Emma V. , Verheij Joanne , Waasdorp Cynthia , Valk Peter J.M. , Engels Sem A.G. , Oostenbach Ellen , van Dinter Jip T. , Hofman Damon A. , Mok Juk Yee , van Esch Wim J.E. , Wilmink Hanneke , Monkhorst Kim , Verheul Henk M.W. , Poel Dennis , Hiltermann T. Jeroen N. , Kempen Léon C.L.T. van , Groen Harry J.M. , Aerts Joachim G.J.V. , Heesch Sebastiaan van , Löwenberg Bob , Plasterk Ronald , Kloosterman Wigard P.
Published: June 2024

Figure S11: Example of a hidden NOP resulting from a complex chromosomal rearrangement in tumor sample LUN022.
Supplemental Figure 4 from Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects
Authors: Menachem Assaf , Alteber Zoya , Cojocaru Gady , Fridman Kfir Tal , Blat Dan , Leiderman Olga , Galperin Moran , Sever Lital , Cohen Nadav , Cohen Keren , Granit Roy Z. , Vols Sandra , Frenkel Masha , Soffer Liron , Meyer Karin , Menachem Keren , Galon Tilleman Hadas , Morein Dina , Borukhov Itamar , Toporik Amir , Perpinial Shahor Michal , Tatirovsky Evgeny , Mizrachi Aviram , Levy-Barda Adva , Sadot Eran , Strenov Yulia , Eitan Ram , Jakobson-Setton Ariella , Yanichkin Natalia , Ferre Pierre , Ophir Eran
Published: June 2024

Supplemental Figure S4. Anti-IL-18BP Ab induced immunogenic memory response in E0771 tumor model.
Supplemental Figure 3 from Unleashing Natural IL18 Activity Using an Anti-IL18BP Blocker Induces Potent Immune Stimulation and Antitumor Effects
Authors: Menachem Assaf , Alteber Zoya , Cojocaru Gady , Fridman Kfir Tal , Blat Dan , Leiderman Olga , Galperin Moran , Sever Lital , Cohen Nadav , Cohen Keren , Granit Roy Z. , Vols Sandra , Frenkel Masha , Soffer Liron , Meyer Karin , Menachem Keren , Galon Tilleman Hadas , Morein Dina , Borukhov Itamar , Toporik Amir , Perpinial Shahor Michal , Tatirovsky Evgeny , Mizrachi Aviram , Levy-Barda Adva , Sadot Eran , Strenov Yulia , Eitan Ram , Jakobson-Setton Ariella , Yanichkin Natalia , Ferre Pierre , Ophir Eran
Published: June 2024

Supplemental Figure S3. Antitumor activity of anti-mouse-IL-18BP Ab in mice studies.
Supplementary Figure 4 from Intratumoral TREX1 Induction Promotes Immune Evasion by Limiting Type I IFN
Authors: Toufektchan Eléonore , Dananberg Alexandra , Striepen Josefine , Hickling James H. , Shim Abraham , Chen Yanyang , Nichols Ashley , Duran Paez Mercedes A. , Mohr Lisa , Bakhoum Samuel F. , Maciejowski John
Published: June 2024

Paclitaxel treatment increases micronucleation, cGAS activity, and TREX1
expression.
Supplementary Figure 6 from The Exonuclease TREX1 Constitutes an Innate Immune Checkpoint Limiting cGAS/STING-Mediated Antitumor Immunity
Authors: Lim Junghyun , Rodriguez Ryan , Williams Katherine , Silva John , Gutierrez Alan G. , Tyler Paul , Baharom Faezzah , Sun Tao , Lin Eva , Martin Scott , Kayser Brandon D. , Johnston Robert J. , Mellman Ira , Delamarre Lélia , West Nathaniel R. , Müller Sören , Qu Yan , Heger Klaus
Published: June 2024

Supplementary Figure 6. TREX1 loss increases CD8 T cell and NK cell activation, limits CD8 T cell exhaustion and enhances the potency of immune checkpoint blockade therapy
Supplemental Table 4 from Randomized Phase II Study Evaluating the Addition of Pembrolizumab to Radium-223 in Metastatic Castration-resistant Prostate Cancer
Authors: Choudhury Atish D. , Kwak Lucia , Cheung Alexander , Allaire Kathryn M. , Marquez Jaqueline , Yang David D. , Tripathi Abhishek , Kilar Jacqueline M. , Flynn Meredith , Maynard Brianna , Reichel Rebecca , Pace Amanda F. , Chen Brandon K. , Van Allen Eliezer M. , Kilbridge Kerry , Wei Xiao X. , McGregor Bradley A. , Pomerantz Mark M. , Bhatt Rupal S. , Sweeney Christopher J. , Bubley Glenn J. , Jacene Heather A. , Taplin Mary-Ellen , Huang Franklin W. , Harshman Lauren C. , Fong Lawrence
Published: June 2024

Clinical characteristics at time of randomization of PSA responders vs. non-responders
Supplemental Figure 8 from Randomized Phase II Study Evaluating the Addition of Pembrolizumab to Radium-223 in Metastatic Castration-resistant Prostate Cancer
Authors: Choudhury Atish D. , Kwak Lucia , Cheung Alexander , Allaire Kathryn M. , Marquez Jaqueline , Yang David D. , Tripathi Abhishek , Kilar Jacqueline M. , Flynn Meredith , Maynard Brianna , Reichel Rebecca , Pace Amanda F. , Chen Brandon K. , Van Allen Eliezer M. , Kilbridge Kerry , Wei Xiao X. , McGregor Bradley A. , Pomerantz Mark M. , Bhatt Rupal S. , Sweeney Christopher J. , Bubley Glenn J. , Jacene Heather A. , Taplin Mary-Ellen , Huang Franklin W. , Harshman Lauren C. , Fong Lawrence
Published: June 2024

Immune cell functional states differ in clinical responders compared to non-responders. (A) Heat maps summarizing log2 fold changes resulting from statistical scaffold analysis of functional markers 4-1BB, CD44, CTLA-4, GITR, HLA-DR, ICOS, Ki-67, OX40, PD-1, PD-L1, PD-L2, TIGIT, TIM3 and VISTA are shown for Week 1, Week 5, and Week 9, when comparing responders to non-responders as defined by rPFS.
Figure S9 from Engineering CD3/CD137 Dual Specificity into a DLL3-Targeted T-Cell Engager Enhances T-Cell Infiltration and Efficacy against Small-Cell Lung Cancer
Authors: Mikami Hirofumi , Feng Shu , Matsuda Yutaka , Ishii Shinya , Naoi Sotaro , Azuma Yumiko , Nagano Hiroaki , Asanuma Kentaro , Kayukawa Yoko , Tsunenari Toshiaki , Kamikawaji Shogo , Iwabuchi Ryutaro , Shinozuka Junko , Yamazaki Masaki , Kuroi Haruka , Ho Samantha Shu Wen , Gan Siok Wan , Chichili Priyanka , Pang Chai Ling , Yeo Chiew Ying , Shimizu Shun , Hironiwa Naoka , Kinoshita Yasuko , Shimizu Yuichiro , Sakamoto Akihisa , Muraoka Masaru , Takahashi Noriyuki , Kawa Tatsuya , Shiraiwa Hirotake , Mimoto Futa , Kashima Kenji , Kamata-Sakurai Mika , Ishikawa Shumpei , Aburatani Hiroyuki , Kitazawa Takehisa , Igawa Tomoyuki
Published: June 2024

Supplementary Figure S9. The use of dexamethasone and tocilizumab does not limit the antitumor efficacy of DLL3 trispecific.
Data from Preclinical Evaluation of Off-The-Shelf PD-L1+ Human Natural Killer Cells Secreting IL15 to Treat Non–Small Cell Lung Cancer
Authors: Lu Ting , Ma Rui , Mansour Anthony G. , Bustillos Christian , Li Zhiyao , Li Zhenlong , Ma Shoubao , Teng Kun-Yu , Chen Hanyu , Zhang Jianying , Villalona-Calero Miguel A. , Caligiuri Michael A. , Yu Jianhua
Published: June 2024

Abstract
We described previously a human natural killer (NK) cell population that upregulates PD-L1 expression upon recognizing and reacting to tumor cells or exposure to a combination of IL12, IL18, and IL15. Here, to investigate the safety and efficacy of tumor-reactive and cytokine-activated (TRACK) NK cells, human NK cells from umbilical cord blood were expanded, transduced with a retroviral vector encoding soluble (s) IL15, and further cytokine activated to induce PD-L1 expression. Our results show cryopreserved and thawed sIL15_TRACK NK cells had significantly improved cytotoxicity against non–small cell lung cancer (NSCLC) in vitro when compared with non-transduced (NT) NK cells, PD-L1+ NK cells lacking sIL15 expression (NT_TRACK NK), or NK cells expressing sIL15 without further cytokine activation (sIL15 NK cells). Intravenous injection of sIL15_TRACK NK cells into immunodeficient mice with NSCLC significantly slowed tumor growth and improved survival when compared with NT NK and sIL15 NK cells. The addition of the anti-PD-L1 atezolizumab further improved control of NSCLC growth by sIL15_TRACK NK cells in vivo. Moreover, a dose-dependent efficacy was assessed for sIL15_TRACK NK cells without observed toxicity. These experiments indicate that the administration of frozen, off-the-shelf allogeneic sIL15_TRACK NK cells is safe in preclinical models of human NSCLC and has potent antitumor activity without and with the administration of atezolizumab. A phase I clinical trial modeled after this preclinical study using sIL15_TRACK NK cells alone or with atezolizumab for relapsed or refractory NSCLC is currently underway (NCT05334329).
Supplementary figure 8 from B7-H3–Targeting Chimeric Antigen Receptors Epstein-Barr Virus–specific T Cells Provides a Tumor Agnostic Off-The-Shelf Therapy Against B7-H3–positive Solid Tumors
Authors: Yeo Siok Ping , Kua Lindsay , Tan Jin Wei , Lim Joanna Kristyn , Wong Fiona HS , Santos May Delos , Poh Chek Meng , Goh Angeline XH , Koh Xin Yu , Zhou Xiaohua , Rajarethinam Ravisankar , Chen Qingfeng , Her Zhisheng , Horak Ivan D. , Low Lionel , Tan Kar Wai
Published: June 2024

Supplementary figure 8
Supplementary Data from B7-H3–Targeting Chimeric Antigen Receptors Epstein-Barr Virus–specific T Cells Provides a Tumor Agnostic Off-The-Shelf Therapy Against B7-H3–positive Solid Tumors
Authors: Yeo Siok Ping , Kua Lindsay , Tan Jin Wei , Lim Joanna Kristyn , Wong Fiona HS , Santos May Delos , Poh Chek Meng , Goh Angeline XH , Koh Xin Yu , Zhou Xiaohua , Rajarethinam Ravisankar , Chen Qingfeng , Her Zhisheng , Horak Ivan D. , Low Lionel , Tan Kar Wai
Published: June 2024

Supplementary Material and Methods
FIGURE 8 from B7-H3–Targeting Chimeric Antigen Receptors Epstein-Barr Virus–specific T Cells Provides a Tumor Agnostic Off-The-Shelf Therapy Against B7-H3–positive Solid Tumors
Authors: Yeo Siok Ping , Kua Lindsay , Tan Jin Wei , Lim Joanna Kristyn , Wong Fiona HS , Santos May Delos , Poh Chek Meng , Goh Angeline XH , Koh Xin Yu , Zhou Xiaohua , Rajarethinam Ravisankar , Chen Qingfeng , Her Zhisheng , Horak Ivan D. , Low Lionel , Tan Kar Wai
Published: June 2024

B7H3.CAR EBVSTs targets MDSCs. A, Flow cytometric histograms of IL10, TGFβ, iNOS, and B7-H3 in MDSCs generated from 2 healthy donors (left). Median fluorescence intensities (MFI) of B7-H3 expressed on MDSCs from 2 healthy donors and the NCI-H1299 cell line (right). B, Cytotoxicity of UT or B7H3.CAR EBVSTs against allogeneic MDSCs. Data compiled from coculture of effector EBVSTs generated from 2 donors and target MDSCs generated from 2 other donors. C, Proliferation of UT and B7H3.CAR EBVSTs after anti-CD3/CD28 stimulation in the presence of allogeneic MDSCs. Each datapoint represents proliferation from each E:T donor pair. Proliferation index was calculated by normalizing percentages of proliferated cells against that of the no MDSC control condition. For B and C, UT versus B7H3.CAR EBVSTs groups were compared using Student unpaired t test. *, P < 0.05; **, P < 0.01; ***, P < 0.001. Error bars denote means ± SD where applicable.
FIGURE 1 from B7-H3–Targeting Chimeric Antigen Receptors Epstein-Barr Virus–specific T Cells Provides a Tumor Agnostic Off-The-Shelf Therapy Against B7-H3–positive Solid Tumors
Authors: Yeo Siok Ping , Kua Lindsay , Tan Jin Wei , Lim Joanna Kristyn , Wong Fiona HS , Santos May Delos , Poh Chek Meng , Goh Angeline XH , Koh Xin Yu , Zhou Xiaohua , Rajarethinam Ravisankar , Chen Qingfeng , Her Zhisheng , Horak Ivan D. , Low Lionel , Tan Kar Wai
Published: June 2024

B7-H3 expression in tumors is higher compared with healthy tissues. A, Grading and pattern of B7-H3 expression in IHC staining of human normal tissues. B, Level and area of B7-H3 expression in gastric cancer tumor bed and adjacent healthy areas. C, Level of B7-H3 expression in gastric cancer tumor stromal. D, Level of B7-H3 expression in healthy breast tissues. E, Level of B7-H3 expression in TNBC. F, H-score for healthy versus tumor breast tissues. For F, groups were compared using Student unpaired t test. ****, P < 0.0001. Each ID or point on the graph represents a patient and error bars denote means ± SD where applicable.
Role of Exercise in Pulmonary Hypertension: Evidence from Bench to Bedside
Authors: Poojary Ganesha , Morris Norman , Joshi Manjunath B. , Babu Abraham Samuel
Published: June 2024

Background: Pulmonary hypertension (PH) is a debilitating condition characterized by elevated pulmonary arterial pressure and progressive vascular remodelling, leading to exercise intolerance. The progression of PAH is regulated at a cellular and molecular level which influences various physiological processes. Exercise plays an important role in improving function in PH. Although the signalling pathways that regulate cardio-protection through exercise have not been fully understood, the positive impact of exercise on the various physiological systems is well established. Summary: Exercise has emerged as a potential adjunctive therapy for PH, with growing evidence supporting its beneficial effects on various aspects of the disease pathophysiology. This review highlights the contributions of cellular and molecular pathways and physiological processes to exercise intolerance. Preclinical studies have provided insight into the mechanisms underlying exercise-induced improvements in PH which are modulated through improvements in endothelial function, inflammation, oxidative stress, and mitochondrial function. Along with preclinical studies, various clinical studies have demonstrated that exercise training can lead to significant improvements in exercise capacity, haemodynamics, quality of life, and functional status. Moreover, exercise interventions have been shown to improve skeletal muscle function and enhance pulmonary vascular remodelling, contributing to overall disease management. Further research efforts aimed at better understanding the role of exercise in PH pathophysiology, and refining exercise interventions are warranted to realize its full potential in the management of this complex disease. Key Messages: Despite the promising benefits of exercise in PH, several challenges remain, including the optimal intensity, duration, and type of exercise training, as well as patient selection criteria and long-term adherence. Additionally, the mechanisms underlying the observed improvements require further elucidation to optimize exercise protocols and personalize treatment strategies. Nonetheless, exercise represents a promising therapeutic approach that can complement existing pharmacological therapies and improve outcomes in PH patients.
Me reconozco y me quiero
Authors: Álvarez Liliana , Gonzalez Restrepo Martha Elena , Hoyos Arcila Maria Elizabeth , Correa Vitola Elida
Published: June 2024

Esta experiencia de clase plantea el reconocimiento del propio cuerpo y el de otros como base para mejorar los procesos de convivencia que se desarrollan en el aula preescolar. El proyecto plantea que el conocer, explorar y vivenciar el propio cuerpo, no sólo en sus partes externas y visibles, sino también aquellas internas que no se ven pero que se sienten y muchas veces se desconocen, acercan al niño y a la niña al reconocimiento de su cuerpo, sus cuidados y sus necesidades para construir personalidad, autonomía, respeto y autoestima, elementos importantes para mejorar las relaciones interpersonales y la convivencia escolar.
Metodología didáctica integrada para el aprendizaje de la lectura y escritura en el grado primero - MEDIP -
Authors: Artunduaga Bermeo Mercedes , Jiménez García Sara
Published: June 2024

En Colombia la educación pública establece que el niño aprende a leer y a escribir en el grado primero (1°), a la edad de seis (6) años, desarrollando las habilidades y destrezas propias para la adquisición de esta competencia. En el municipio de Florencia, se presenta una problemática en lo pedagógico por parte de los docentes que atienden este grado y en lo administrativo por parte de los directivos en la asignación del docente ocasionando índices significativos de repitencia y deserción.

Ante esta problemática surge la propuesta pedagógica denominada Metodología Didáctica Integrada para la Lectura y Escritura en el Grado Primero, MEDIP. Esta consiste en la elección de una frase o expresión a partir de un evento de interés para los niños@, para desarrollar todo un proceso de aprendizajes significativos partiendo de aprendizajes previos, potencializando estructuras mentales cada vez más complejas.

Como modelo educativo contribuye a solucionar el problema de ampliación de cobertura y ofrece a los padres de familia mayor garantía para evitar la reprobación y garantizar la permanencia. Para el sistema educativo del país, la MEDIP hace un aporte significativo por cuanto garantiza efectivamente la movilidad de los niños del grado primero en la edad escolar requerida, evitando la extra edad de la población estudiantil.
La literatura infantil, territorio lúdico para leer y escribir con sentido, desde la diversidad
Authors: Mantilla Landazábal María Janeth
Published: June 2024

Leer y escribir significativamente en escuelas inclusivas con estudiantes sordos y oyentes de preescolar y básica primaria, exige del educador un cambio de paradigma en la concepción de estos procesos para apreciarlos como realidades globales del acto de explorar y comprender el contexto, siempre desde el reconocimiento de las identidades particulares de las comunidades de sordos y oyentes que invita a posicionar, en igualdad de importancia, a las lenguas nativas características de cada una de estas comunidades. Desde esta realidad del encuentro de lenguas viso-gestuales y auditivo-orales surgen nuevas posibilidades de re-significar métodos de enseñanza, estrategias y recursos para enseñar y aprender con una propuesta creativa rica en lenguajes visuales y expresivos que ofrece la literatura. A partir de textos literarios se comunican dos mundos, dos poblaciones, dos lenguas principales que abren otros canales de encuentros comunicativos y de caminos posibles para acceder al conocimiento. La literatura infantil se convierte territorio que inspira no sólo las posibilidades integradoras de acceder a la palabra hablada, escrita y gestuada con igualdad de derechos para las comunidades de sordos y oyentes sino la oportunidad para que la pedagogía y la didáctica construyan el andamiaje que dé garantías de aprendizaje significativo de los saberes escolares.
Maestro en espera…
Authors: Lucía Restrepo Diana
Published: June 2024

Los maestros de hoy tenemos el inmenso compromiso de acercarnos a cada niño que llega a nuestro salón de clase, pues cada uno de ellos es una edición nueva de consciencia que viene a cumplir una misión específica, y aunque ellos lo saben, nos buscan para que nos sintonicemos con los nuevos lenguajes y energías, que serán el caldo de cultivo en donde se generarán ambientes saludables y armónicos para que él se encuentre consigo mismo más tarde o más temprano, según las experiencias vivas que la escuela le posibilite hoy.

Los maestros vienen al aula de clase en busca de una guía que oriente sus potencialidades y alimente sus certezas para entregarle al mundo un nuevo mensaje, un nuevo conocimiento y una nueva dimensión de la realidad basada en el amor, la que se requiere con urgencia para consolidar este hermoso proyecto llamado Humanidad.
Disciplina con amor: una experiencia de convivencia escolar
Authors: León Roa Jorge
Published: June 2024

La experiencia que se presenta se denomina Disciplina con Amor busca mostrar el sentido que tienen el afecto y la comunicación en la vida escolar, para pasar de formas sancionatorias de convivencia, a formas de convivencia escolar desde el respeto a las diferencias y la inclusión.
Formacion de pensamiento crítico desde la filosofía
Authors: Santis Iriarte Efrain
Published: June 2024

La práctica pedagógica evidencia para el maestro la necesidad de plantearse una revisión de sus estructuras conceptuales, de las acciones educativas utilizadas en su desempeño, la visión que posee del estudiante y la actitud frente a la formación, siendo la reflexión el medio y proceso que ofrece la opción para enrumbar el camino pedagógico.

En este nace la experiencia que rescata la visión del maestro aprendiz, conllevando a asumir una actitud reflexiva de la formación profesional y desempeño pedagógico que se realiza y del producto de la acción formativa, denominada por Schön (1992), reflexión en la acción como acción reflexiva de una situación problemática concreta y donde hace uso de un conocimiento de segundo orden o metaconocimento en la acción. Esta acción reflexiva, o pensamiento producido por el docente sobre lo que hace, permite, por un lado, establecer una manera de asumir la misión educativa y formadora guiada por la intencionalidad de cumplirla eficazmente, a la vez que emprende la búsqueda de estrategias pedagógicas y didácticas a través de las cuales lograrla. De otro lado, comprende que en su labor hace presencia la incertidumbre como generadora de interrogantes pedagógicos a abordar para identificar los problemas formativos que se deben intervenir.
Pequeños Escritores
Authors: Álvarez Uribe Lina Maria
Published: June 2024

Posterior a un diagnóstico que arroja, de un lado, rupturas constantes en el trato interpersonal entre niños(as) y, de otro, bajos niveles de comprensión y producción textual, es menester una propuesta que se apuntale en diversas manifestaciones del lenguaje (verbal y extraverbal) y que se apropie de herramientas como las TIC. Así mismo, para su ejecución, no se pueden desestimar factores asociados, relacionados con las familias, los compañeros, el entorno, las normas, las dificultades individuales, las metodologías y prácticas de los docentes, la falta de espacios adecuados y de insumos, entre otros. Tampoco se puede perder de vista que la construcción de saberes en el aula, instala dos actores principales, maestro-alumno, en una permanente conversación que se construye, que se escribe y reescribe.
Pedagogias do Sul: contos africanos como prática educacional decolonial
Authors: Oliveira Antonia Magaly Conceição de , Ornellas Larissa Soares , Akoa Patrick
Published: June 2024

African tales as an object of study present the relationship between education and culture, from a decolonial perspective. As cultural and educational elements, it shows that the acts of teaching and learning are linked to the life of a people, to its contemporary culture. These stories, which are based on men and animals, allow a multi-inter-transdisciplinary dialogue. Teaching is done through mimes, interjections, songs, and voice modulations. The signs present are new educational paradigms, so learning is based on concrete life. It is about teaching the keys, an educational instrument that, in practice, combines oral and gestural arts. As an educational practice, an education and culture, allowing them to dialogue towards the same humanizing objective of social/cultural/economic life. All of this manifests its decolonial characteristics because there is no education without culture nor is there culture without education.
Empresas e tiktok: um estudo sobre narrativas e reputação
Authors: Paula Naira de Oliveira Luiz de , Santa-Cruz Lucia
Published: June 2024

O ambiente das mídias sociais influencia diversos aspectos em nossa sociedade e a relação entre consumidores e marcas não fica de fora desse contexto. O Brasil tem 79,9% da sua população com participação ativa em pelo menos uma rede social. Neste cenário, este artigo busca identificar qual o objetivo dos consumidores ao se relacionarem com as marcas de forma indireta, no TikTok, e não pelos canais oficiais da empresa. A marca escolhida para este estudo foi a marca Carrefour, por fazer parte do Grupo Carrefour Brasil, maior empresa de varejo do país. O pressuposto que se busca identificar é se o uso do TikTok pelos consumidores tem como objetivo afetar a reputação da marca. Em termos de metodologia, se trata de uma abordagem qualitativa com o objetivo exploratório. Em relação aos resultados, eles ampliam o argumento pressuposto.
Comparison of the immunohistochemical profile between women with breast cancer over 40 and under 40 years old
Authors: Alves Thales Müller Silvério , Nogueira Rodrigo Justi , Bagio Tony Maronesi , Quirino Louzada Mário Jefferson , Katsuda Paulo Gil , Camilo-Júnior Deolino João , Xavier-Júnior José Cândido Caldeira
Published: June 2024

Objective: To compare immunohistochemical profiles, such as surrogate molecular classifications of breast carcinomas and histological findings, among women under and over 40 years of age. Methods: This was an observational, quantitative, and retrospective study based on data from the Instituto de Patologia de Araçatuba (IPAT), located in the countryside of the state of São Paulo, Brazil. Pathology reports from biopsy or surgical excision recorded between January 1, 2017, and June 30, 2020 (42 months) were reviewed. Only ductal and lobular carcinomas were histologically analyzed. Age, histological subtype, and immunohistochemical data of estrogen receptor, progesterone receptor, Her-2 and Ki-67 (< 20% x ≥ 20%) were analyzed. Specimens were categorized into two groups based on patient age at diagnosis (≤ 40 years vs. > 40 years). Results: There was no significant difference between the two age groups regarding hormone receptor, Her-2 evaluation, or histological classification (ductal vs. lobular). Nevertheless, breast cancer in younger women was associated with a higher Ki-67 index (p = 0.015). In the group aged 40 years and younger, half of the cases were classified as Luminal B-like, Her-2 negative, and 19% were triple-negative. For women over 40 years old, 57% were classified as luminal B-like, Her-2 negative, 9% were luminal A-like, and only 13% were triple-negative. Conclusion: The frequency of breast among young woman is substantial, and they tend to exhibit higher Ki-67 indexes.
Lazer e Refugiados no Município de São Paulo: um estudo nas Organizações Não Governamentais Abraço Cultural e Compassiva
Authors: Santos Bárbara Cardoso da Costa , Aulicino Madalena Pedroso
Published: June 2024

Este artículo aborda la vida de refugiados de nacionalidades: siria, congoleña, beninesa, boliviana, marfileña y cubana en una nueva sociedad y que residen en Brasil desde hace algunos años, vista desde la perspectiva de la inserción a través del ocio. A partir de esto, se intentó identificar las dificultades encontradas para acceder a equipamientos y espacios de ocio y encontrar información sobre posibles prácticas al respecto. Además, se evaluaron giras planificadas por las ONG Abraço Cultural y Compassiva que trabajan con refugiados en la ciudad de São Paulo, ayudándolos a instalarse en el país y, más que eso, brindando actividades de ocio para todos. La metodología de este trabajo es de carácter exploratorio, lo que apunta a un enfoque con un estudio de caso como método, porque investiga un fenómeno contemporáneo en un contexto de la vida real, y en la medida en que recurrió a una estrategia de investigación integral incluyendo entrevistas y observación de actividades de ocio con refugiados, como visitas a museos de la ciudad de São Paulo y un taller gastronómico en la Escuela de Artes, Ciencias y Humanidades de la Universidad de São Paulo; Las entrevistas se aplicaron a seis refugiados, tres de Abraço Cultural y tres de Compassiva. Los resultados mostraron que los entrevistados no reportaron dificultades para acceder a equipos de ocio, ni para encontrar información sobre estas mismas actividades, incluso informaron que se sentían seguros en las actividades proporcionadas por las dos ONG en cuestión.
Object-Oriented Ontology in Shaping Perspective on Bacterial Art and Nonhuman Agency
Authors: Ismail Roslina , Hanafi Amira , Jusoff Kamaruzaman
Published: June 2024

The study of bacterial art provides an opportunity to investigate the philosophical framework of object-oriented ontology (OOO). This viewpoint challenges traditional human-centered perspectives by highlighting the autonomy and agency of all objects, including microorganisms. Objects have their own inherent properties and are regarded as equal actors in the world. The authors highlight the dynamic relationship between humans and microorganisms and the agency of bacteria in bioart. Bacterial art raises concerns regarding control, authorship, aesthetics, and ethics, necessitating interdisciplinary discussions and critical evaluations. This study provides an intriguing case examining the implications of OOO at the intersection of science and art.
Disagreement on the North Atlantic Cold Blob Formation Mechanisms among Climate Models
Authors: Fan Yifei , Chan Duo , Zhang Pengfei , Li Laifang
Published: June 2024

Despite global warming, the sea surface temperature (SST) in the subpolar North Atlantic has decreased since the 1900s. This local cooling, known as the North Atlantic cold blob, signifies a unique role of the subpolar North Atlantic in uptaking heat and hence impacts downstream weather and climate. However, a lack of observational records and their constraints on climate models leave the North Atlantic cold blob formation mechanism inconclusive. Using simulations from phase 6 of Coupled Model Intercomparison Project, we assess the primary processes driving the North Atlantic cold blob within individual models and whether the mechanisms are consistent across models. We show that 11 out of 32 models, which we call “Cold Blob” models, simulate the subpolar North Atlantic cooling over 1900–2014. Further analyzing the heat budget of the subpolar North Atlantic SST shows that models have distinct mechanisms of cold blob formation. While 4 of the 11 Cold Blob models indicate decreased oceanic heat transport convergence (OHTC) as the key mechanism, another four models suggest changes in radiative processes making predominant contributions. The contribution of OHTC and radiative processes is comparable in the remaining three models. Such a model disagreement on the mechanism of cold blob formation may be associated with simulated base-state Atlantic meridional overturning circulation (AMOC) strength, which explains 39% of the intermodel spread in the contribution of OHTC to the simulated cold blob. Models with a stronger base-state AMOC suggest a greater role of OHTC, whereas those with a weaker base-state AMOC indicate that radiative processes are more responsible. This model discrepancy suggests that the cold blob formation mechanism diagnosed from single model should be interpreted with caution.

Significance Statement

The mechanisms driving sea surface temperatures over the subpolar North Atlantic to cool since the 1900s remain uncertain due to the lack of direct observations. Here, we use a temperature change decomposition framework to dissect the historical trend of surface temperature simulated in multiple global climate models. The models diverge on whether the subpolar North Atlantic cooling is induced by reduced ocean heat transport convergence or altered radiative processes. Notably, the importance of ocean heat transport convergence is influenced by the simulated base-state strength of Atlantic meridional overturning circulation and the Irminger Sea’s mixed layer depth. This finding cautions against concluding the cooling mechanism from a single model and highlights a need for ongoing observations to constrain AMOC-related climate projection in the subpolar North Atlantic.
Shared Capitalism and Corporate Sustainability: Broad-Based Employee Share Ownership, CEO Ownership, and Corporate Environmental Performance
Authors: Lee Jegoo , Kruse Douglas L. , Blasi Joseph R.
Published: June 2024

This research proposes that broad-based employee share ownership (ESO) affects corporate environmental performance (CEP). Drawing upon corporate governance literature, social exchange theory, and stakeholder utility theory, we propose that employees as owners adopt more favorable attitudes toward beneficial outcomes for CEP, and that the broad-based impact of ESO overwhelms the impact of CEO ownership. Also, we propose that these relationships are contingent upon trade union presence as a form of worker voice that amplifies the ESO influence on CEP. The empirical results from U.S. publicly traded companies from 2009 to 2016 indicate that broad-based ESO is linked to positive CEP by companies, and provides some support for all proposed hypotheses. This study provides scholarly and practical implications for the effects of shared capitalist modes of ownership and employee engagement on corporate sustainability.
Effects of periodic sequential arrangement of subscale miura-foldcore under quasi-static compression
Authors: Mortensen Chase , Nielsen Devin , Shah Syed Zulfiqar Hussain , Lee Juhyeong
Published: June 2024

This study presents experimental and numerical investigations on the quasi-static compressive responses of various subscale Miura-foldcore composites. A series of quasi-static compression tests were conducted on standard Miura foldcore specimens fabricated using carbon/epoxy woven fabric prepregs. Representative volume element (RVE) models, incorporating periodic boundary conditions (PBCs), were developed to predict the size-dependent compressive response of subscale Miura foldcores. The effective properties of the carbon/epoxy woven fabric composite used in this study were calculated using the NASA multiscale analysis tool (NASMAT) via two-step homogenization process. The FE model exhibited comparable agreement with experimental results, showcasing variations of less than 7% and 12% in maximum compressive load and compressive stiffness, respectively. The implementation of PBC in the foldcore RVE models improved modeling accuracy by <4%, but drastically increased total computational time (>50%). The periodic pattern of foldcore unit-cells, where two single foldcore unit-cells were placed in parallel or perpendicular, imposed geometric constraints, resulting in small variations in predicted stress and strain distribution contours. The key findings highlighted in this study suggest that a 1 × 1 foldcore unit-cell model without PBC is sufficient to predict accurate quasi-static compressive responses of foldcore composites. This study advances the understanding of subscale Miura-foldcore composites and provides valuable insights into the limitations associated with the use of PBC in foldcore RVE models. The findings also offer a practical guide for fabricating and analyzing traditional Miura folding patterns, promoting a more efficient and accurate approach for optimizing foldcore composite designs considering both structural performance and manufacturability.
How Does Empowering Leadership Relate to Work Engagement? The Roles of Organisational Identification and Workplace Well-Being
Authors: Liu Saifang , Han Xiaoxi , Du Lei , Zhu Honghai , Shi Runze , Lan Jijun
Published: June 2024

Scholars tend to believe that effective leadership contributes to facilitating employee work engagement. Based on social identity theory and self-determination theory, this study explored how empowering leadership affects employee work engagement through the mediating roles of organisational identification and workplace well-being. A sample of 3645 front-line employees in China participated in this study. A structural equation model analysis was performed to examine the hypothetical model. Sex, age, degree of education, wage income per month (RMB), and subjective social class were covariables. The results indicated that (a) empowering leadership was positively related to work engagement, (b) organisational identification and workplace well-being played a partial mediating role in the relationship, and (c) organisational identification and workplace well-being had a chain mediating effect on empowering leadership and work engagement. These findings advance the understanding of the effect of empowering leadership on employees’ working attitudes and behaviours. They also contribute to potential interventions that boost employee work engagement.
Intermediaries and the digital transformation of schooling: An introduction
Authors: Hartong Sigrid , Geiss Michael , Röhl Tobias
Published: June 2024

In this editorial, we outline origins and evolutions of (studying) intermediaries in the field of education. While intermediaries have played a significant role since the establishment of mass education in the 19th century, it was not until the broader transformation from government to governance from the 1970s onwards that intermediaries became visible – and investigated – as a distinct field of powerful actors. The more recent digital transformation of education can, on the one hand, be situated within these broader evolutions. On the other hand, the rise of digital technologies, data infrastructures and platform has also significantly impacted, and further empowered, the field of intermediaries. With this Special Issue, which consists of five contributions, we aim at a closer disentanglement of these recent transformations. In this editorial, each contribution is briefly discussed individually, before outlining some overall findings of the issue.
Wireless transmission of vital body data and ambient magnetic field with wearable IoT device attached smart textile
Authors: Dalkılıç Hakan , Özdemir Hakan , Özcanhan Mehmet Hilal
Published: June 2024

The use of smart textiles is expanding. The wearer’s data are transferred to the Cloud by a mobile device, and shared with authorized parties. The study aims to monitor continuously and share our wearable smart textile’s heartbeat, body temperature, and the surrounding magnetic field data, providing early intervention before negative health events occur, or a high magnetic field is of concern to its wearer. A heartbeat sensor, a temperature sensor, and an ESP32 module with a built-in Hall effect sensor were integrated with a special conductive wire woven fabric. The data measured by the sensors were sent to the cloud server wirelessly by the ESP32. Our custom-made software analyzes the collected data with statistical methods, enabling the generation of predictions and early warnings. The generated reports can be sent to the smart textile user, doctors, and authorized third-party health institutions, and relevant magnetic field authorities. Our study shows that the body temperature reported by the designed smart textile has less than a 2.0% error compared with the actual value. On the other hand, the reported heartbeat has a 11.0% error, as it largely depends on sensor quality and placement location. In addition to these, continuous monitoring of the ambient magnetic field has been achieved with smart textiles. Our smart textile design sends the wearer’s body temperature, heartbeat, and surrounding magnetic field information to a cloud server automatically and wirelessly. Our custom-made software and mobile application use the data to provide early warnings and live reports on users’ mobile devices.
Black Mothering Communities as Homeplaces for Black LGBTQ+ Youth
Authors: Reid Shamari K. , Reid Jaron , Reid (posthumous) Donna
Published: June 2024

In our critical duo-ethnography, we reflect on our shared childhood as Black queer youth growing up within a Black mothering community in an urban context. Our analysis illustrates how our Black mothering community created homeplaces centered around the themes of resistance, restoration, and re-storying. And we draw on our analysis to articulate the possibilities of creating more inclusive K-12 spaces within urban contexts for Black LGBTQ+ youth. Specifically, we offer concrete examples from our Black mothering community to assist schools and education stakeholders in transforming schools into sites of resistance, restoration, and re-storying for Black LGBTQ+ youth.
Who Predicts? Scientific Authority and User Expertise in Dutch Storm Warnings 1860-1920
Authors: Baneke David
Published: June 2024

This paper shows that expert authority can be the result of a process of co-construction by scientists and users, using the case of the Netherlands’ storm warnings system. I analyze the changing “culture of prediction” of the Netherlands’ storm warnings system between 1860 and about 1920, focusing on the changing relation between scientific experts and users with experience-based expertise. When started, the storm warnings relied on users taking an active role. The new storm warning system, introduced by Buys Ballot in 1860 following the introduction of telegraph networks, explicitly tried to mobilize sailors’ weather wisdom. Following complaints from the maritime community and controversies about criteria for accuracy or reliability around 1900, storm forecasting authority became the exclusive domain of scientists. Interestingly, the authority of experts was not challenged during this controversy. Rather, the debates focused on mutual expectations of expertise and on whether the storm warning system was primarily a scientific or a practical system. This paper is based on historical documentation from the archives of the Royal Netherlands Meteorological Institute, which includes the perspectives of users.
Creating Interpretative Spaces in and with Digital Infrastructures: How Editors Select Reviewers at a Biomedical Publisher
Authors: Hesselmann Felicitas , Hartstein Judith
Published: June 2024

Digital infrastructures, such as editorial management systems (EMS), play a crucial role in academic publishing. However, despite their ubiquity, they have received surprisingly little analytical attention. Here, we investigate how EMSs are employed in practice and contribute to editorial evaluations. Conducting a case study of a biomedical publisher, we investigate the selection of peer reviewers by editors, using both qualitative and quantitative data. When looking at how interactions between editors and the digital infrastructures unfold, we observed three analytically different types of interaction: (1) editors and infrastructure jointly accomplish the acceleration of peer review, (2) editors mitigate the infrastructure when establishing a collective memory, and (3) editors disengage from the infrastructure when they evaluate potential reviewers. Through strategic disengagement from and mitigation of the infrastructures, editors create interpretative spaces for themselves. This way, most of the interpretative and evaluative work still remains in the domain of the human editorial staff. Our results furthermore highlight the importance of the specific spatial, social, organizational, and cultural conditions of the editorial office for editors’ ability to modulate their engagement with the infrastructures, create interpretative spaces, and shape infrastructural effects.
How could the Library and Information Studies curriculum better prepare graduates to address equity, diversity and inclusion issues in their workplace?
Authors: Drewry Catherine , Matsuno Sae , Hicks Alison , Inskip Charlie
Published: June 2024

Equity, diversity and inclusion (EDI) practices in the library and information professions can be linked to the curriculum of the professional qualification, which plays an important role in preparing students for practice. The aim of this small, non-generalisable survey of recent graduates at one UK library school, a collaboration between two academic staff and two current and recent students, was to identify how the curriculum could better prepare graduates to address EDI issues in their workplace. Approaches for cultivating effective pedagogical strategies included the importance of recognising and exploring personal identity; group work and community building and embedding an EDI ethos, approach and method within the curriculum. Important gaps relating to the preparation of students for EDI practices that were noted included management and leadership; fostering learner positionality and addressing the broad scope of EDI work including all protected and other characteristics, alongside tensions between individual and structural approaches to change.
The influence of personal factors on resistance to technology adoption in university libraries in Bangladesh
Authors: Rahman Md. Habibur , Ahmad Azree Bin , Mohamed Sawal Mohd Zool Hilmie Bin
Published: June 2024

This research explores the impact of personal factors on resistance to technology adoption in university libraries in Bangladesh, particularly among LIS (Library and Information Science) professionals. The study aims to reveal specific challenges and opportunities influencing attitudes toward technology integration, offering a nuanced understanding of resistance factors in this unique cultural and educational context. Through a qualitative case study with 21 LIS professionals from seven university libraries, conducted via semi-structured interviews guided by a questionnaire, recurring themes such as fear of job displacement, perceived technological self-efficacy, and concerns about disruptions to workflows emerge. Fear of job displacement refers to professionals’ apprehension about potential job loss due to technological advancements, while perceived technological self-efficacy reflects individuals’ confidence in using and adapting to new technologies. Concerns about disruptions to workflows highlight worries regarding the impact of technology implementation on existing work processes. Despite challenges, participants acknowledge potential benefits, emphasizing improved services. The study advocates for crucial strategies like comprehensive training programs and inclusive decision-making processes to alleviate resistance. This research provides a focused exploration, original insights, and practical value for advancing technology adoption in university libraries in Bangladesh, contributing to a deeper comprehension of complexities in technology integration within academic institutions.