bluuebunny/crossref_metadata_2025 huggingface dataset:
Pemikiran Pendidikan Imam Al-Ghazali dan Relevansinya dalam Sistem Pendidikan Islam Kontemporer
Authors: Madhar Madhar
Published: February 2025

This study examines the relevance of Imam Al-Ghazali's educational thought in contemporary Islamic education, focusing on goals, curriculum, teaching methods, and the teacher's role. Using a literature review with descriptive-analytical methods, the study analyzes Al-Ghazali’s ideas and related literature. The findings highlight that Al-Ghazali’s holistic educational concept, which integrates religious and worldly knowledge, provides solutions to modern challenges, such as moral crises, materialism, and globalization. Imam Al-Ghazaliviewed education as a means of shaping noble character and closeness to Allah SWT, with a balanced approach to cognitive, emotional, and spiritual development. His ideal curriculum combines religious and worldly sciences, while teaching methods emphasize exemplary behavior, reflection, and personalized approaches. Teachers are regarded as moral exemplars with a significant responsibility for guiding students intellectually and ethically. This study emphasizes the importance of integrating spiritual values into modern Islamic education curricula and enhancing teachers' roles as character builders. These findings contribute significantly to the development of an Islamic educational system that prepares intellectually capable, morally upright, and ethical generations to effectively address global challenges.
EKOLOJİ ÇİRKLƏNMƏNİN İQTİSADİ TƏSİRLƏRİNİN AZALDILMASI YOLLARI
Authors: Həcər İsmayılova, Rüfət Abdurəhmanlı Həcər İsmayılova, Rüfət Abdurəhmanlı
Published: February 2025

Environmental pollution emerges as one of the most pressing global challenges of our time, characterized by a multidisciplinary nature that profoundly affects both ecosystems and economic stability. This concept encompasses a multidimensional reality, illustrated by the destructive effects of toxic substances generated by industrial processes, carbon emissions from the transportation sector, and the widespread use of pesticides in agriculture. Such circumstances signify that the environment is undergoing a transformation marked by resource depletion and a decline in biodiversity. Contemporary research in Azerbaijan demonstrates that the socio-economic consequences of environmental pollution give rise to multifaceted problems not only in the short term but also in the long run. For instance, pollution of natural resources, particularly industrial waste-laden water bodies, leads to a decrease in agricultural productivity, causing significant setbacks in economic performance indicators. Furthermore, rising pollution levels adversely impact human health, imposing additional financial burdens on the healthcare system, which in turn puts the nation’s overall economic resources to the test. Analyzing environmental issues in the context of economic development highlights the necessity of adopting green technologies and sustainable consumption models. In this regard, implementing green supply chains in Azerbaijan is considered a progressive approach, both for reducing environmental pollution and enhancing economic efficiency. Key measures for ensuring ecological safety include managing radioactive waste, optimizing energy production processes, and developing recycling mechanisms. On a global scale, Azerbaijan’s engagement in international cooperation and the implementation of modern environmental standards could lead to a qualitative transformation in the country’s economic development model. Such an approach would not only mitigate the economic and ecological impacts of pollution but also pave the way for achieving strategic long-term sustainable development goals. Thus, the application of an integrated approach to the economic impacts of environmental pollution should be regarded as one of the primary mechanisms for both environmental protection and economic modernization.
Keywords: Environmental pollution, economic impacts, environmental responsibility, human health, sustainable development
From Awareness to Action: HIV Prevention Programs in Poor Communities
Authors: Obeagu Emmanuel Ifeanyi
Published: February 2025

HIV remains a significant public health concern in low-income communities, where the prevalence of the disease continues to rise despite increased awareness efforts. While many awareness campaigns have successfully educated individuals on HIV transmission and prevention, the transition from knowledge to action remains a considerable challenge. This review explores the effectiveness of HIV prevention programs in impoverished communities, highlighting the barriers to translating awareness into practical behavior change. Factors such as poverty, limited healthcare access, stigma, and cultural norms all play a role in hindering individuals from adopting preventive measures, underscoring the need for more comprehensive interventions. To bridge the gap between awareness and action, HIV prevention programs must adopt a multi-faceted approach. Effective initiatives incorporate community involvement, access to services, and behavioral interventions tailored to the unique needs of each community. Engaging local leaders and addressing the broader socioeconomic determinants of health can enhance the impact of these programs, ensuring greater participation and adherence to preventive measures. Additionally, reducing HIV-related stigma is essential to foster a supportive environment for individuals seeking HIV testing, counseling, and prevention tools.
Basics of Management of Calcium and Bone Disorders
Authors: Boutrus Tamer Shalaby
Published: February 2025

Calcium homeostasis is maintained by three hormones (parathyroid hormone (PTH), 1,25-dihydroxyvitamin D3, and calcitonin. PTH acts on the kidneys to increase calcium reabsorption and secretion of Vitamin D3 by activating 25 (OH) Vit D3 to 1,25-dihydroxyvitamin D3, and on bones it stimulates osteoclasts leading to bone reabsorption and release of free calcium. Vitamin D3 stimulates calcium absorption from the gut.

Calcitonin on the other side do the opposite to PTH and Vitamin D3, it is released from the thyroid parafollicular cells and acts on the bones to deposit calcium in case of hypercalcaemia, Calcitonin increases urinary calcium excretion and inhibits absorption in the intestines.

Hypomagnesemia will reduce parathyroid hormone leading to calcium deficiency, common scenario with Proton pump inhibitor. FGF23 causes renal phosphate wasting and low 1,25(OH)2D3 in normal kidney function but its effect is lost in advanced kidney disease. Elevated FGF23 from bones occurs in X-linked hypophosphatemia rickets, hypophosphatemia rickets type 1, and tumour-induced osteomalacia due to FGF23-producing tumours.
Proboscis Lateral: A Case Report
Authors: Hafsi Montacer
Published: February 2025

Introduction: The lateral proboscis is a rudimentary nasal structure located off the vertical midline of the face. This malformation is often accompanied by other anomalies, most commonly ophthalmic conditions such as anophthalmia, microphthalmia, and colobomas, as well as facial anomalies like maxillary hypoplasia or facial clefts, and cranio-cerebral anomalies including encephalocele and holoprosencephaly.

Methods: This report presents a case of a newborn with a lateral proboscis identified at birth. The pregnancy was poorly monitored, and the anomaly was discovered immediately after delivery.

Results: The newborn exhibited a lateral proboscis with a rudimentary nasal structure extending from the right side of the face, along with associated ophthalmic anomalies including microphthalmia. No additional facial clefts or cranio-cerebral abnormalities were noted. The infant was managed with early reconstruction plans and supportive care.

Discussion: Early reconstruction is recommended, starting at a young age. Cartilaginous or bony support may be considered by the end of adolescence to achieve a satisfactory aesthetic result. This case highlights the importance of early diagnosis and intervention for optimizing outcomes in such rare malformations.

Conclusion

The presented case of lateral proboscis demonstrates a favorable outcome despite the challenges associated with this rare condition. Early surgical intervention and proper management are crucial for achieving positive results and improving the patient's quality of life.
Amniotic Fluid Embolism: A Case Study
Authors: Hafsi Montacer
Published: February 2025

Introduction: Amniotic fluid embolism (AFE) is a rare but catastrophic obstetric emergency characterized by the sudden onset of cardiovascular collapse, respiratory distress, and coagulopathy, often leading to maternal and fetal mortality. Despite advancements in obstetric care, AFE remains a critical challenge due to its unpredictable nature and poor prognosis.

Case presentation: Authors report a case of AFE confirmed histologically in a 42-year-old primiparous woman. The patient was induced at 41 weeks and five days of gestation due to post-term status. Following a routine delivery of a healthy 4100g infant with an Apgar score of ten at five minutes, she experienced severe postpartum hemorrhage. An artificial delivery was performed, and subsequent administration of oxytocin and sulprostone did not control the hemorrhage.

Methods: The patient fell into a deep coma and suffered a cardiac arrest lasting 15 minutes, for which immediate resuscitation efforts were initiated. Due to persistent hemorrhage and signs of disseminated intravascular coagulation (DIC), a hemostatic hysterectomy was performed. During surgery, the patient experienced a second cardiac arrest lasting three minutes. Postoperative management involved intensive care support, but the patient unfortunately succumbed on the third postoperative day due to multi-organ failure. Histological examination of the hysterectomy specimen confirmed the presence of amniotic fluid embolism.

Results: The case highlights the severe and rapid progression of AFE, leading to critical complications including multi-organ failure and death despite aggressive medical and surgical interventions. The histological confirmation of AFE underscores the diagnostic challenge and the need for heightened awareness of this condition among obstetricians.

Discussion: AFE remains one of the most daunting emergencies in obstetrics due to its rapid onset and high mortality rate. Early recognition and prompt, aggressive management are crucial. However, the condition’s rarity and the absence of specific pre-mortem diagnostic tests complicate early diagnosis and intervention. This case emphasizes the need for improved strategies for early detection and management of AFE.

Conclusion: Amniotic fluid embolism, despite its rare occurrence, presents a significant threat to maternal and fetal health. This case underlines the importance of understanding the condition's severe implications and the need for preparedness and rapid response to manage its devastating effects.
Triple Source Thirteen Level Inverter
Authors: Prasanna Lakshmi , Jyothsna T. R.
Published: February 2025

Multilevel inverters are attracting the attention of investigators concerning high-power and mediumpower applications. Interestingly, an arrangement with a couple of devices is popular in an attempt to enhance efficacy and durability. This work suggests a Triple Source Thirteen Level Inverter based on minimal device count. By integrating three voltage sources with eight semiconductor devices, the proposed design develops thirteen levels. Gating signals are created using the Phase Disposition Pulse Width Modulation (PDPWM) technique. To compute efficiency along with losses PLECS software is used. The successful configuration implementation is investigated using MATLAB/Simulink under various parametric conditions. The proposed topology is tested using Hardware-In-the-Loop (HIL) experiments to validate its feasibility.
Leveraging Deep Learning for Drowning and Swimming Prevention
Authors: Ünlü Türkalp Türker , Mahamat Abakar Li̇mane , Turan Meti̇n
Published: February 2025

Drowning is a severe public health problem that has claimed many lives in Turkey. Our study focuses on a novel strategy to address this problem. We developed a semi-automated technique that uses drone technology and machine learning to prevent drowning in real time. Advanced convolutional neural network (CNN) models, including Xception, ResNet-50, and YOLOv8, were used in our approach. These various models were trained using a special dataset that included simulated drowning situations in the Turkish Aegean Sea and a collection of online images. Though fully automated operation cannot be ensured, this method greatly improves water safety by guiding the drone to the drowning event and alerting the relevant staff. The models performed admirably with relative accuracy rates of 82.1%, 83.40%, and 85.8%. This cutting-edge approach demonstrates how machine learning could fundamentally alter the way major health concerns are handled. It also demonstrates how, when integrated with traditional safety procedures and human supervision, technology can improve and assist human efforts to safeguard the public's health.
A Study on No Arbitrage Pricing Theory Using Discrete-time and Continuous-time Approaches
Authors:   Korea Real Estate Society, Kim Haeng Jo
Published: February 2025

The real estate market is characterized by high volatility and intense competition. In particular, investment decision-making in real estate development needs to be more flexible in response to uncertain environmental changes, including legal and economic factors. No Arbitrage Pricing Theory is a framework that determines the prices of financial derivatives based on the assumption that no arbitrage opportunities exist in the financial market. This theory requires a pricing structure that eliminates risk-free opportunities for guaranteed profits across various financial products.
The objective of this study is to compare the differences between discrete-time and continuous-time approaches within the No Arbitrage Pricing Theory, which is one of the pricing theories in financial engineering. Specifically, this research aims to examine the concept of no arbitrage, the Markov properties of each model, and the replicability of the payoffs of complete options from a practical perspective.
By analyzing No Arbitrage Pricing Theory, this study explores methods for assessing uncertainty in real estate prices from the viewpoint of financial engineering, including methods for evaluating real estate returns, risk analysis techniques, rental derivative valuation methods, and real estate option valuation approaches.
Building on this research, various analytical methods are expected to develop, and this study may play a fundamental role in that advancement.
Pengaruh Fintech, Perilaku Keuangan dan Persepsi Kemudahan Terhadap Pengambilan Keputusan oleh Mahasiswa untuk Melakukan Pinjaman Online
Authors: Ronadi Violina Jasmine , Permatasari Anita
Published: February 2025

ABSTRACT
ABSTRACT
The variables used in this research are financial technology, financial behavior and perceived convenience which can influence students' decision making to take out online loans. The data used in this research is primary data obtained from questionnaires. The results of this research are that financial technology influences students' decision making to take out online loans.  The results of the second research in this study are that financial behavior influences students' decision making to take out online loans. The third research result is that the perception of convenience has no influence on students' decision making to take out online loans.
 
 
Keywords: Financial Technology, Financial Behavior, Perception of Convenience, Online Loans
Real-Time Temperature Monitoring VHMS Dashboard Development to Reduce Component Unscheduled Breakdown
Authors: Nur M. Hidayatullah , Hendriana Dena , Baskoro Gembong
Published: February 2025

The coal mining industry relies on heavy equipment such as excavators and bulldozers and their efficiencies are critical for the productivity. This paper addresses the issue of unscheduled breakdowns due to high operational temperatures which impacts productivity, equipment availability and maintenance costs. The existing Vehicle Health Monitoring System (VHMS) from Komatsu Original Manufacturing lacks of real-time data for coolant temperature. The data recording is only every 20 hours and data reporting to the monitoring system is transferred daily. This lack of data is leading to unable for identifying the causes of problems. This study proposes a real-time temperature monitoring dashboard for the VHMS to track and manage Komatsu equipment temperature limits and to upgrade the existing system to record temperature data in every second instead of every 20 hours. This fine data collection provides enough information for a comprehensive analysis of machine conditions. This allows for quick identification of abnormal temperature trends, leading to timely maintenance and failures prevention. The new dashboard system provides immediate access to detailed temperature data, facilitating prompt decision-making in maintenance process. It also involves setting new temperature limits to prevent overheating and reduce unscheduled component breakdown from 25% in 2019 to 0% in 2023 and 2024. Implementing a real-time temperature monitoring dashboard is expected to improve equipment availability, reduce breakdowns, optimize maintenance schedules and lower operational costs in the coal mining industry.
Store Novelty dan Loyalitas Toko: Pengaruh Mediasi Store Design Complexity dan Store Design Pleasure
Authors: Raynaldi Aldwin , Supriharyanti Elisabeth , Mawasti Alpi
Published: February 2025

One of the biggest challenges faced by the retail sector in the digital era is maintaining customer loyalty to stores. This study aims to analyze the effect of store novelty on store loyalty, with store design complexity and store design pleasure as mediating variables. The study employed a purposive sampling method, involving 120 respondents who were customers of fashion stores in Surabaya. Data collection was conducted using a questionnaire distributed online via Google Forms. The collected data were analyzed using the Partial Least Square (PLS) technique with the SmartPLS 3.0 application. The results show that store novelty does not have a direct effect on store loyalty; however, it has an indirect effect mediated by store design complexity and store design pleasure. These findings provide significant contributions to the retail management literature, particularly regarding strategies for building and maintaining customer loyalty. From a managerial perspective, the study recommends that store managers focus on innovative designs emphasizing variety and comfort to create a unique and enjoyable shopping experience for customers. Effectively managing engaging and complex store design elements can serve as a powerful strategy to enhance customer loyalty amidst the increasing competition in the retail industry.
Factors affecting the efficacy of drug therapy in patients with plaque psoriasis
Authors: Khokhlov A. L. , Samarina E. I. , Lileeva E. G.
Published: February 2025

Relevance. The selection and modification of drug therapy for patients with plaque psoriasis does not have a specific solution for practicing specialists. Factors have been identified that can worsen the course of the disease when therapies with proven clinical efficacy are used and can even increase the severity and prevalence of the psoriatic process, leading to the development of erythroderma or resistance to the therapy. This article analyzed the actual clinical practice of plaque psoriasis therapy and the influence of concomitant diagnoses on the choice of therapy by physicians among patients who were treated in skin and venereal disease dispensaries in the Central Federal District from 2022 to 2023.

Objective. To conduct a pharmacoepidemiological analysis of drug prescriptions and the volume of their consumption for plaque psoriasis using frequency analysis and analysis of average daily doses at the outpatient and inpatient stages of treatment, followed by a search for patterns.

Materials and methods. An open, non-randomized, cross-sectional prospective study of outpatient records and hospital discharge summaries of 336 patients diagnosed with L40.0 plaque psoriasis was conducted over 2 years. Patients were surveyed by their physicians regarding their adherence to the physician recommendations using a questionnaire on adherence to therapy. The presence of complications of the primary diagnosis, concomitant diagnoses, and factors influencing the prescription of methotrexate and monoclonal antibodies were analyzed.

Results. Patients prescribed methotrexate drugs had significantly more concomitant diseases (p <0.05). In addition to the primary diagnosis, patients treated with methotrexate had significantly less of the following: psoriatic arthritis, polyarthritis, spondyloarthritis, dactylitis, enthesitis, and psoriatic onychodystrophy compared with the group of patients who were prescribed genetically engineered biological drugs (p <0.05). The multivariate analysis revealed the influence of skin lesion severity and patient adherence on therapy choice.

Conclusions. Among patients prescribed genetically engineered drugs, concomitant complications of an arthropathic nature were significantly more common — in 32.5 % of cases, versus 18.2 % in the group of patients on methotrexate (p <0.05). Therefore, the choice in favor of monoclonal antibodies in most cases was due to the presence of arthropathic psoriatic complications, skin lesion severity, younger age, and high adherence to the innovative therapy prescribed by the doctor (p <0.05).
Prevalence and severity of chronic kidney disease in a therapeutic hospital in patients with hypertension, angina pectoris, and type 2 diabetes mellitus: real practice of treating
Authors: Pegashova M. A. , Chizhov P. A. , Smirnova M. P. , Medvedeva T. V. , Кorkina M. I.
Published: February 2025

Relevance. Chronic kidney disease (CKD) develops in the context of many diseases and has a progressive course, with the outcome of chronic renal failure.

Objective. To study the prevalence and severity of CKD in patients of the therapeutic department with hypertension, coronary heart disease (CHD) by type of angina 2-3 FC (NYHA), type 2 diabetes mellitus (T2DM) and their combinations, as well as the real practice of therapy of such patients.

Materials and methods. A total of 193 patients (average age 64.0 ± 18.1 with hypertension, CHD, T2DM, and their combinations were examined and treated in the therapeutic department of the N.A. Semashko City Hospital in the Yaroslavl Region was closed due to deterioration of their condition. The glomerular filtration rate (GFR) was calculated using the CKD-EPI formula. Statistical processing of the results was performed using the Statistica 12.0 program (StatSoft. Inc., USA).

Results. CKD stage 1 was diagnosed in 4.3% of the examined patients, stage 2 in 18.2%, stage 3 in 42.6%, and stage 4 in 2.9%. CKD stages 1 and 2 were significantly more common in patients with isolated hypertension, compared with those examined with hypertension + coronary heart disease + T2DM (p = 0.01, p = 0.03, respectively). CKD stage 3 was diagnosed in 100% of patients with T2DM + coronary heart disease. In patients with stage 3 hypertension and 3 FC CHF (NYHA), obesity, the GFR was significantly lower in men than in patients with stage 1 and 2 hypertension, with 2 FC CHF, no obesity, and women. Correlations of GFR with age and duration of hypertension and T2DM were established. The shortcomings of pharmacotherapy of patients with CKD in the hospital were revealed: no one receives IDPP-4 and gliflozins, some patients with low SCF receive metformin, some do not receive angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, statins, and some patients with type 2 diabetes did not undergo proper titration of the dose of hypoglycemic drugs.

Conclusions. CKD stages 1–4 were detected in 68% of patients with hypertension, coronary heart disease, and/or type 2 diabetes in the therapeutic hospital, of which 42.6% had stage 3 and 2.9% had stage 4. The GFR value was associated with the degree of hypertension, FC CHF (NYHA), obesity, sex, age, hypertension duration, and type 2 diabetes. In hospitals, recommendations for pharmacotherapy for patients with CKD are not always followed.
Pathogenetic features of functional disorders in the remaining kidney during the early postoperative period of radical nephrectomy
Authors: Shormanov I. S. , Kosenko M. V. , Shchedrov D. N. , Zhigalov S. A. , Solovyov A. S. , Sokolova H. A.
Published: February 2025

Relevance. Despite the widespread introduction of organ-preserving operations into urological practice, the number of radical nephrectomies has continued to increase. The results of modern research show that the initial stages of diseases of the remaining kidney are already formed at the earliest possible time after radical nephrectomy; therefore, adequate management of the postoperative period is a key factor in the prevention of diseases of the single kidney. However, this approach should be based on a detailed understanding of the mechanisms of adaptive restructuring of the body, which have a key effect on the morphology and function of a single kidney.

Objective. To study the features of adaptive body reactions and the dynamics of the functional state of a single kidney following radical nephrectomy.

Materials and methods. In the early postoperative period, the clinical and laboratory parameters of 85 patients who underwent radical nephrectomy for renal cell carcinoma in the T2-T3N0M0 stage were studied. The control group comprised 25 patients who underwent similar operations for the same indications within a period of 1.5–12 months. The metabolism of adrenaline, histamine, and serotonin, indicators of psychological and emotional states, vegetative-vascular status, and nitrogen excretion and filtration functions of the remaining kidney were studied.

Results. Radical nephrectomy, as well as the period of conscious expectation, is the cause of a stress syndrome that occurs due to an imbalance of the studied biogenic amines, accompanied by disorders of psychological and emotional health and vegetative-vascular disorders observed at least during the 2 weeks of the postoperative period. In addition, the filtration capacity of a single kidney is impaired, and it persists for 14 days at follow-up. Correlation analysis made it possible to establish reliable links between the imbalance of biogenic amine and anxiety levels and the severity of autonomic vascular disorders, which adversely affect kidney filtration.

Conclusions. The results of this study indicate the need for pharmacological subsidies during the postoperative period of radical nephrectomy, which makes it possible to offset the negative impact of stress syndrome on the outcome of surgical treatment.
Regional blockage as a component of reduced mammoplasty multimodal pain relief
Authors: Ganert A. N. , Lyuboshevskiy P. A. , Sokolov D. A.
Published: February 2025

Relevance. Postoperative pain management remains poorly understood. Analgesics traditionally used to treat postoperative pain have numerous side effects. The optimal method for preventing postoperative pain is based on the principle of multimodality, where in addition to the use of analgesics with different application points, regional blockades are applied. In chest wall surgery, blockage of the thoracic nerves (PEC block) and the space of the muscles of the spine straightener (ESP block) under ultrasound control are gaining popularity.

Objective. We compared the analgesic efficiency of PEC block and ESP block in multimodal analgesis without opioids during the postoperative period of reduction mammoplasty.

Materials and methods. Sixty patients were examined with bilateral reduction mammography. Three groups were selected: PEC group of the block (n=20), ESP group of the block (n=20), and control group (n=20). The amount of fentanyl and inhalant anesthetic consumed, postoperative pain on Visual Analogue Scale (VAS), side effects of analgesics, and patient activation were evaluated.

Results. Intraoperative fentanyl and inhalant consumption were significantly lower in the block PEC and block ESP groups than in the control group. The post-wake and 1and 3-hour postoperative pain syndrome rates were significantly lower in the block PEC and block ESP groups than in the control group.

Conclusions. ESP-block and PEC-block are effective regional anesthesia methods that provide good intra- and postoperative analgesia. They also have a significant opioid-saving effect. They allow significantly earlier activation of patients. ESPblock slightly surpassed PEC block in duration, but other differences were not.
Clinical and practical use of domestic and imported articaine during difficult clinical situations during maxillofacial surgery in outpatient dentistry: case study
Authors: Put S. A. , Bessonov S. N. , Skukhtorov V. V.
Published: February 2025

Relevance. The study aimed to compare the depth of anaesthesia, effectiveness, and hemostasis when using two articaine-based drugs: «Articaine-Binergia with epinephrine» 1:200000 and «Ubistesin forte» 1:100000, using a clinical case of the removal of tooth buds 38 and 48 in the lower jaw under conscious sedation in a patient with pronounced dental phobia. Articaine drugs, domestic «Articaine-Binergia with epinephrine» 1:200000 and imported «Ubistesin forte» 1:100000, are approved for use in the Russian Federation. The novelty of this study lies in the application of drugs from the same group of different manufacturers on the same patient under symmetrical clinical conditions by one specialist at the same level of trauma. No such studies were found in the literature.

Objective. The aim of this study was to compare the effectiveness of domestic and imported analogues of local anaesthetics based on articaine in a single patient. The methodological objective is to assess the depth of anaesthesia, effectiveness, and hemostasis, as well as the patient’s subjective sensations and level of dental anxiety.

Materials and methods. A review of the clinical case allows for the assessment of patients' subjective sensations during sedation with preserved consciousness against the background of taking sedative drugs and central analgesics using the «painno pain» scale. The level of dental anxiety was also determined using the Corah's Dental Anxiety Scale. Sedative drugs were used at doses that did not provide complete anaesthesia in the surgical intervention area, allowing the patient to clearly respond to pain stimuli during local, particularly conductive anaesthesia.

Results. Under conditions of intravenous sedation with preserved consciousness, pain sensations are mitigated when local anaesthesia is ineffective, thereby reducing the patient’s psychological discomfort. The use of «Articaine-Binergia with epinephrine» 1:200000 and «Ubistesin forte» 1:100000 allowed for an objective comparison of their effectiveness and safety.

Conclusions. Stable hemodynamic indicators on the monitors indicate high-quality anaesthesia and the absence of pain sensations; otherwise, the indicators on the monitor would have fluctuated. The data obtained confirm that both articaine-based drugs have similar effectiveness and provide an adequate level of anaesthesia in clinical intervention conditions, reducing the patient's anxiety and discomfort. One clinical case is not definitive; therefore, further research with a larger amount of statistical data is required.
Analysis of the registration and manufacturing of heparin drugs in Russia
Authors: Lavrentyeva L. I. , Zakharov A. V.
Published: February 2025

Objective. To analyze the circulation processes of heparin group drugs for 2004–2024 from the point of view of the rates of registration and localization of production of active pharmaceutical substances (APS), finished dosage forms, and prospects for implementing a full production cycle in Russia.

Materials and methods. An analysis of information from 693 registry entries in the State Register of Medicines dedicated to heparin-based drugs was conducted, and a database was compiled in Microsoft Excel. Information on registered drugs was classified according to their belonging to the heparin group, the name of the APS, dosage form, date of registration, presence in the list of vital and essential drugs, country of manufacture of the APS, and finished dosage forms.

Results. In accordance with the anatomical-therapeutic-chemical classification, more than 20 names of drugs were classified as heparin group drugs: unfractionated heparin, low-molecular-weight heparin, heparinoid, and antithrombin III. 95 current registration certificates (hereinafter referred to as RC) and 13 RC excluded from the State Register of Medicines were studied — a total of 108 RC. Graphs were constructed to reflect the rate of drug registration in each named group. The highest rates of registration are observed in the period from 2020 to 2024 — on average 5.25 drugs are approved per year. The years with the most active registration were 2011 (11 approved drugs), 2017 (8 approved drugs), and 2023 (9 approved drugs). The production localization of heparin drugs for 2024 is presented in the diagrams. The main country producing APS for heparin drugs is China. However, for every fifth heparin drug, the full production cycle can be performed in Russia, including the synthesis of APS.

Conclusions. Information was received on the structure of the product range (95 drugs are presented in 10 dosage forms for 5 different routes of administration), rate of registration of drugs in the heparin group, and localization of production of the APS, finished dosage form. The production of APS for sodium heparin is concentrated in China. Information is known about the construction in the coming years in Russia of three production sites for the production of the APS of sodium heparin: by the Chinese company “Hebei Changshan Biochemical Pharmaceutical”, the Russian company’s “Pharmasyntez-Kama” and “Severnyj ocean”. At present, only Russian companies are declared to be suppliers of APS is 3 drugs. Heparin drugs are mainly produced in Russia (75.4 % for sodium heparin drugs and 65.1 % for low-molecular-weight heparin).
Erythrocytic indices of clinical blood analysis and reference intervals among men and women aged 18–45 years
Authors: Rechkina O. P. , Adamov D. D. , Stribets T. B. , Lapkina N. A . , Baranov A. A. , Mineeva L. A. , Belyaeva N. V. , Malakhov N. V.
Published: February 2025

Relevance. The determination of reference intervals (RI) in clinical blood analysis for erythrocytes and their specific parameters: mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and red cell distribution width (RDW), allows us to use these parameters for differential diagnostics of various pathological conditions from variants of norm.

Objective. Calculate the RI for erythrocyte parameters of a complete blood count for patients in a certain age group (18– 45 years) with normal indicators of iron homeostasis. The reference ranges may vary depending on the analytical systems and diagnostic reagents used.

Material and methods. The study included blood samples from 158 healthy volunteers aged 18–45 years, of whom 127 (80.4 %) were women and 31 (19.6 %) were men. The data were obtained from the «KDL-TEST» company database for the period from 01.01.2023 to 01.01.2024. The criteria for inclusion in the study were: age from 18 to 45 years, clinical blood test results, and iron homeostasis within the RI of the «KDL-TEST» laboratory, absence of signs of an inflammatory process based on normal levels of C-reactive protein (CRP). Analyses were performed using a hematological analyzer Mindray BC- 6800 (manufactured by Mindray, China) and an automatic biochemical analyzer model AU-5800 (Beckman Coulter, USA) using IRON reagents (Beckman Coulter, USA) for the photometric colorimetric method and CRP-latex (Beckman Coulter, USA) immunoturbidimetric method.

Results. The studies revealed a decrease in the upper limit of the RI for red blood cells (RBC) and their indices (RBC, HGB, HCT, MCV, MCH, MCHC, RDW-CV) in women compared with the RI of the Russian National Standard (2009), which amounted to 4 % for the number of red blood cells, 5 % for hemoglobin, 2 % for hematocrit, 3.8 % for MCV and 3.5 % for MCH, as well as 4.2 % for MCHC; and a decrease in the upper limit of the RI of erythrocytes and erythrocyte indices (RBC, HGB, HCT, MCV, MCH, MCHC, RDW-CV) in relation to the RI of the Russian National Standard (2009) in men for erythrocytes by 3.9 %, hemoglobin by 4, 6 %, MCV — by 1.9 %, MCH — by 4 %, MCHC — by 5.8 %. No significant differences were found in the values of erythrocytes and their specific parameters, hemoglobin, and hematocrit, between the data of the hematology analyzers Mindray BC-6800 and Sysmex XE series (p >0.05).

Conclusions. A decrease in the RI of clinical blood analysis in women and men for some hemogram parameters (RBC, HGB, HCT, MCV, MCH, MCHC, RDW-CV) in comparison with the RI of clinical blood analysis of the Russian National Standard (2009), which are within the generally accepted statistically acceptable deviations, was found. The use of automated hematology analyzers did not significantly affect the RI of erythrocytes or their specific parameters.
Features of the activities of information and analysis in the internal affairs bodies
Authors:   Independent researcher of the Academy of the Ministry of internal affairs, Uzbekistan, Satimbaevich Saidov Jasurbek
Published: February 2025

The article outlines the peculiarities of the information and analytical activities carried out in the internal affairs bodies and important aspects of systematic thinking and systematic analysis in the functioning of the information and analysis system in it, and outlines ideas on the concept of systematic analysis from a scientific point of view.
Effectiveness of Physical Therapy with Kinesio Taping in the Treatment of Patients with Knee Ligament Injuries
Authors: Cherniak V.P. , Stepanova H.M. , Dashko K.S. , Kravets A.O.
Published: February 2025

Background. Kinesio taping is a therapeutic technique gaining popularity in knee injury treatment. The method is based on the use of a highly elastic adhesive material that allows free mobility of the treated body area.
Objective. The aim of this study was to evaluate the effectiveness of kinesio taping in restoring joint functionality.
Materials and Methods. A comparative analysis was conducted between two groups of patients: the control group (basic rehabilitation) and the experimental group (basic rehabilitation with kinesio taping).
Results. At baseline, both groups had comparable clinical and functional indicators, including pain level, the Oswestry Disability Index, knee joint range of motion, and muscle strength. After the rehabilitation course, both groups demonstrated positive dynamics, with knee flexion amplitude improving by approximately 90% and extension by 70%. However, the kinesio taping group demonstrated statistically significant advantages: muscle strength increased by 36.46% (versus 14-17% in the control group), Lower Extremity Functional Scale scores improved by 44.55% (versus 5.33%), postural stability increased by 29.85% (versus 0.73%), and Hauser’s walking index improved by 30.51% (versus 3.33%). No statistically significant between-group differences were found in pain reduction (approximately 49% in both groups) and improvement in the Oswestry Disability Index (approximately 52%).
Discussion. These results can be explained by the fact that kinesio taping provides additional proprioceptive stimulation and mechanical support during rehabilitation exercises, facilitating more effective recovery of muscle strength and postural control.
Conclusions. The study confirms that incorporating kinesio taping into comprehensive rehabilitation program significantly enhances its effectiveness, particularly in restoring muscle strength, postural control and overall lower limb functionality, although showing no advantages in pain control or certain specific functional parameters compared to standard rehabilitation programs. These findings have important practical implications for optimizing rehabilitation protocols and rational use of kinesio taping in physical therapy for patients with knee ligament injuries.
Analysis Of City Branding Strategies In Increasing Visitor Attraction (Case Study On Tourism History Of Marlborough Fort, Bungkarno House In Bengkulu Province)
Authors: Indriani Reni , Veronika Nora
Published: February 2025

This research aims to analyze the city branding strategy used to increase visitor attraction in Bengkulu Province, with a focus on historical tourism objects such as Fort Marlborough, Bung Karno's House, and the British Cemetery. The research methodology employed was descriptive in nature, utilizing a qualitative approach. Data collection involved conducting interviews with relevant stakeholders and conducting direct observations on-site. Analysis was carried out on the city branding strategy applied to this historical tourism object and its impact on increasing the number of visitors. The research results show that the implementation of city branding in the historical destination of Bengkulu still needs more attention, especially in the aspects of image management, promotion and local community participation.
Talent Management On Individual Work Performance: Managerial Support As A Mediator
Authors: Adiyanto Rajendra Zaid , Fajri Annisa
Published: February 2025

This paper examines the influence of perceived organizational support on employee performance and overall success. An effective talent management process can improve individual work performance by providing appropriate rewards to employees who do their jobs and achieve targets, thereby contributing to individual and organizational success. The research results also show that the mediating influence of work involvement or perceived organizational support has a significant influence on employee creativity and indirectly influences employee creativity. Setting clear and achievable work goals or targets is important for an effective performance appraisal process.
Determinants Of Intention To Use Cash Management System In The Government Agencies With Organization Culture As A Moderating Variable
Authors: Widyastuti Aditya , Rosidi Rosidi , Iqbal Syaiful
Published: February 2025

The use of Cash Management System (CMS) in government work units is a form of modernisation in the government payment system to improve the efficiency, effectiveness and accountability of government financial management. CMS provides time and cost-efficient benefits and minimizes security risks for financial management but the use of CMS by government work units is not optimal. This study aims to analyze the determinants that influence intention to use CMS, with the variables tested being perceived usefulness, attitude, subjective norms, and trust with organizational culture as moderator variables. The study used SEM PLS to analyze the data by involving 267 samples who were financial management officials at the Ministry of PUPR. The results prove that intention to use CMS is determined by trust, attitude and subjective norms. Perceived usefulness is not proven to affect intention to use CMS and organizational culture is not proven to moderate CMS acceptance. The limitation of the study is that the measurement of organizational culture is limited to the values adopted by the Ministry of PUPR, while organizational culture has broad aspects. Future research can measure organizational culture from different aspects
Analysis Of Key Factors Influencing Behavioral Intention To Adopt Cryptocurrency In Indonesia: A Demographic Perspective
Authors: Lie I Gede Artha Juan Christian , Faturohman Taufik
Published: February 2025

This study examines the key factors influencing the behavioral intention to adopt cryptocurrency in Indonesia from a demographic perspective. Utilizing descriptive statistics and non-parametric tests such as the Mann-Whitney U Test and Kruskal-Wallis Test, the research analyzes how gender, age, educational level, and occupation impact individuals' perceptions and intentions regarding cryptocurrency adoption. The findings reveal significant differences across these demographic groups, particularly in areas such as financial literacy, perceived risk, social influence, and awareness. Males, younger individuals, and those with higher education levels or finance-related occupations exhibit a stronger intention to adopt cryptocurrency, driven by lower perceived risks and higher financial literacy. Conversely, females, older adults, and those with lower education levels show more hesitation, primarily due to higher perceived risks and lower awareness. The study underscores the need for targeted educational initiatives and policy interventions to address these demographic disparities and promote a more inclusive adoption of cryptocurrency in Indonesia. These insights are crucial for developing effective strategies to support the growth of cryptocurrency as part of the digital economy.
Implementation Of Information Management System In Supporting Administrative Services At The Population And Civil Registration Services (DUKCAPIL) Gunungsitoli City
Authors: Zebua Delmanius , Hulu Fatolosa
Published: February 2025

This study discussed how the implementation of Information Management Systems in support of administrative services at the Department of Population and Civil Registration (Dukcapil) Gunungsitoli. Implementation of the Information Management System in support of administrative services at the Department of Population and Civil Registration (Dukcapil) Gunungsitoli. As well as having uses from various parties, both from the research site and from the author himself. Basically, this study uses descriptive qualitative research methods, using observation guidance instruments, interviews and documentation in data collection. Data analysed using methods of data collection, data reduction, data presentation, and conclusion. This study determines the subject and object of research with reference to the interview guidelines for conducting interviews, observations and and questionnaires as a complement. The results of this study indicate that the implementation of Management Information Systems in support of administrative services at the Department of Population and Civil Registration (Dukcapil) Gunungsitoli has been well implemented by using all facilities/ facilities and infrastructure as well as the application of SIAK as a stepping stone in optimizing the application of Management Information Systems. Efforts to improve the quality of service to the community are increasing because it is supported by a variety of administrative services more quickly and effectively
The Influence Of Time Budget Pressure And Locus Of Control On Audit Judgment Of The BPKP Aceh
Authors: Susanti Eva , Syawalina Cut Fitrika , Khaira Fathul
Published: February 2025

The purpose of this research is to determine the influence of time budget pressure, internal locus of control and external locus of control on audit judgment. This research is quantitative research and uses a questionnaire which is distributed to respondents. The selection of respondents was based on a purposive sampling technique on 58 auditors at the Aceh Financial and Development Supervisory Agency (BPKP) Representative office. The data analysis method used in this research is multiple linear regression analysis. The research results show that  Simultaneously the time budget pressure, internal locus of control and external locus of control abilities influence the audit judgment. Furthermore the results of partial hypothesis testing show that the time budget pressure has a positive abilities influence on audit judgment, internal locus of control has a negative abilities influence on audit judgment, external locus of control has a positive abilities influence on audit judgment.