bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure 5 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Authors: O’Connor James P.B. , Tessyman Victoria , Little Ross A. , Babur Muhammad , Forster Duncan , Latif Ayşe , Cheung Susan , Lipowska-Bhalla Grazyna , Higgins Geoff S. , Asselin Marie-Claude , Parker Geoff J.M. , Williams Kaye J.
Published: October 2024

MRI elucidates differential drug mechanism of action for banoxantrone and atovaquone. Banoxantrone did not cause growth inhibition in (A) Calu6 xenografts or (B) U87 xenografts. Atovaquone did not cause growth inhibition in (C) Calu6 xenografts. D and E, Calu6 and U87 xenografts show reduction in volume of hypoxic tumor with banoxantrone by day 3. Similarly, (F) Calu6 xenografts show reduction in volume of hypoxic tumor with atovaquone by day 7. G and H, Calu6 and U87 xenografts show companion increases in volume of necrotic tumor, whereas (I) no change in volume of necrotic tumor is detected in Calu6 xenografts treated with atovaquone. J and K, No change in volume of normoxic tumor is detected in Calu6 or U87 xenografts treated with banoxantrone, whereas (L) Calu6 xenografts treated with atovaquone show increase in normoxic tumor. Changes described are all relative to baseline.
Figure 4 from Combined Oxygen-Enhanced MRI and Perfusion Imaging Detect Hypoxia Modification from Banoxantrone and Atovaquone and Track Their Differential Mechanisms of Action
Authors: O’Connor James P.B. , Tessyman Victoria , Little Ross A. , Babur Muhammad , Forster Duncan , Latif Ayşe , Cheung Susan , Lipowska-Bhalla Grazyna , Higgins Geoff S. , Asselin Marie-Claude , Parker Geoff J.M. , Williams Kaye J.
Published: October 2024

Banoxantrone (BN) hypoxia modification is replicated in U87, a xenograft model with different growth and hypoxia characteristics. U87 xenografts were less hypoxic than Calu6 xenografts. The group average ΔR1 for size matched (A) Calu6 was less than that for (B) U87 xenografts. Error bars are SEM. Significant difference between (C) group ΔR1 and (D) group MRI hypoxic volume were observed between the two tumor models. Examining the U87 xenografts further, (E) U87 Cohort reduction in MRI hypoxic fraction was seen at day 3 in treated drug tumors, relative to control tumors (Cn; white bars), with (F) U87 example segmented MRI images showing hypoxic (blue), normoxic (yellow), and necrotic (gray) tumor. G, Lower percentage of pimonidazole staining was detected in drug-treated U87 tumors at day 3, compared to controls. H, Example pimonidazole adduct formation images (×40 magnification).
Figure S2 from Exosomal Thomsen–Friedenreich Glycoantigen: A New Liquid Biopsy Biomarker for Lung and Breast Cancer Diagnoses
Authors: Hsu Chang-Chieh , Su Yafei , Rittenhouse-Olson Kate , Attwood Kristopher M. , Mojica Wilfrido , Reid Mary E. , Dy Grace K. , Wu Yun
Published: October 2024

Supplementary Figure S2. SPR assay demonstrated exosomes carry TF-Ag-α. Exosomes were isolated from cancer patient serum samples using both total exosome isolation kit (from serum) (ThermoFisher) and exoRNeasy midi kit (Qiagen). Significantly higher levels of TF-Ag-α were observed in exosome samples isolated using both kits than the exosome-depleted serum samples. The exosome concentration was 3.29x10^11 exosomes/mL.
Supplementary Figure 6 from SREBP-Dependent Regulation of Lipid Homeostasis Is Required for Progression and Growth of Pancreatic Ductal Adenocarcinoma
Authors: Ishida Chiaki T. , Myers Stephanie L. , Kubota Casie S. , Shao Wei , McGuire Meredith R. , Liu Chune , Ewachiw Theodore E. , Mukhopadhyay Debaditya , Ke Suqi , Wang Hao , Rasheed Zeshaan A. , Anders Robert A. , Espenshade Peter J.
Published: October 2024

FIGURE S6 – Site-1 protease activation of the SREBP pathway is required for PDAC cell growth in low serum conditions.
Supplementary Figure 3 from SREBP-Dependent Regulation of Lipid Homeostasis Is Required for Progression and Growth of Pancreatic Ductal Adenocarcinoma
Authors: Ishida Chiaki T. , Myers Stephanie L. , Kubota Casie S. , Shao Wei , McGuire Meredith R. , Liu Chune , Ewachiw Theodore E. , Mukhopadhyay Debaditya , Ke Suqi , Wang Hao , Rasheed Zeshaan A. , Anders Robert A. , Espenshade Peter J.
Published: October 2024

FIGURE S3 – Generation of human PDAC SCAP knockout cell lines
Supplementary Figure 1 from SREBP-Dependent Regulation of Lipid Homeostasis Is Required for Progression and Growth of Pancreatic Ductal Adenocarcinoma
Authors: Ishida Chiaki T. , Myers Stephanie L. , Kubota Casie S. , Shao Wei , McGuire Meredith R. , Liu Chune , Ewachiw Theodore E. , Mukhopadhyay Debaditya , Ke Suqi , Wang Hao , Rasheed Zeshaan A. , Anders Robert A. , Espenshade Peter J.
Published: October 2024

FIGURE S1 – Scap is not required for development or function of the mouse pancreas.
Open-class-ness, Aspect, Iconicity, and Other Characteristics of Japanese Ideophones Viewed through the Lens of Closed-class Semantics
Authors: Toratani Kiyoko
Published: October 2024

This paper adopts closed-class semantics (Talmy, 2000) to examine the semantics and morphophonology of Japanese ideophones. First, it considers the class category status of ideophones, arguing that the membership expansion of ideophones as open-class forms is impeded by iconicity, or the sound-symbolism of a phoneme. Next, it explores the relevance of three grammatical concepts expressed by closed-class forms (aspect, force dynamics, and perspective) to the meaning of ideophones, arguing that: (i) the forms of ideophones are iconic representations of (un)boundedness; (ii) ideophones can elaborate on the force enacted by the antagonist or agonist; and (iii) a proximal perspective underlies commonly used descriptions, such as dramaturgicness. The discussion touches on cross-linguistically common characteristics of ideophones, including use of a closed-class means such as reduplication to create aspect-informed forms. The paper shows that the class category status is an important measure to seize characteristics of ideophones, corroborating Dingemanse (2019, 2023).
Polyphony in Text and Discourse: A Cognitive Semantics Multimodal Case Study on Parenthesis and Quotation
Authors: Lampert Martina , Lampert Günther
Published: October 2024

Essentially grounded in Cognitive Semantics and conceived to capture fundamental compositional properties inscribed in (written) text and (spoken) discourse, this study proposes a unifying account of parenthesis and quotation in English. Understood as determinants of conceptual structure in language, these two categories, though ubiquitous in all forms of language use, but so far entirely missing from the Cognitive Semantics, research agenda, are (re-)conceptualized under the aegis of Bakhtin’s polyphony and voice, and Goffman’s decomposition of the speaker as ‘fictive’ polyphony. In achieving this goal, the paper explores via dense, multimodally informed micro-studies of authentic text and discourse how voices are made salient to readers and hearers, scrutinizing various categories of cuing devices. As a corollary, Cognitive Semantics is seen to be developed and enriched, opening it up to transcend the language system, thus paying respect to the ‘total linguistic fact’ in the sense of Silverstein.
The research politics of (re)naming participants: A sociology of names perspective
Authors: Deakin-Smith Hannah , Pilcher Jane , Flaherty Jan , Coffey Amanda , Makis Eve
Published: October 2024

In this article we argue that theoretical and empirical insights from the sociology of people's names can enrich qualitative researchers’ decision-making about, and descriptions of, their practices of (re)naming participants as well as inform methodological debates about these practices. We review the research politics of participants’ names and outline how issues of anonymisation and pseudonymisation can be thought through using sociological theorising about and empirical research on people's names. In illustration of the value of this perspective, we discuss (re)naming of participants in our study of names in adoption. We describe the challenges that arise around anonymisation and pseudonymisation when the topic is potentially sensitive and where people's names are the focus. We draw out the broader significance of our findings to encourage researchers, regardless of their topic, to better reflect on and account for choices made about why and how research participants are (re)named.
Household income is associated with attack frequency, but not with the prevalence of headache: an analysis of self-reported headache in the general population in Germany
Authors: Müller Britta , Gaul Charly , Reis Olaf , Jürgens Tim P. , Kropp Peter , Ruscheweyh Ruth , Straube Andreas , Brähler Elmar , Förderreuther Stefanie , Rimmele Florian , Dresler Thomas
Published: October 2024

Background

Headache disorders are among the most prevalent neurological disorders worldwide. However, whether groups differing in socioeconomic position (SEP) are disproportionately affected by headache disorders has not yet been adequately clarified. Our aim was to analyse (1) the headache prevalence by socioeconomic position (SEP) and (2) the attack frequency by SEP in a German population-based adult sample.

Methods

Cross-sectional data from a random general population were used. The sample included N = 2,189 participants aged ≥ 18 years. SEP was measured using net equivalised income (NEI) and education. A binary logistic regression model tested the effect of SEP in predicting the prevalence of headache in general. Ordinal logistic regressions were modeled to predict the effect of SEP on the likelihood of attack frequency. Attack frequency was categorized in low frequency episodic headache (LFEH: 0–3 days per month), moderate frequency episodic headache (MFEH: 4–14 days per month) and chronic headache (CH: ≥ 15 days per month).

Results

Of the 2,189 participants, 891 reported headache in the last six months. Neither income nor education was associated with headache prevalence. However, significant differences between income groups were found for attack frequency. Compared to participants with NEI > 150%, those with NEI < 60% were 5.21 times more likely (95%CI 2.03, 13.36) to experience higher headache frequency, and those with NEI between 60 and 150% were 2.29 times more likely (95%CI 1.02, 5.11), with adjustments made for a set of potential confounders, including depressive symptoms.

Conclusions

To reduce headache attacks, it is essential to address both low- and middle-income groups affected by headaches. Universal public health prevention campaigns are particularly appropriate.
Systematic review of prognostic factors for poor outcome in people living with dementia that can be determined from primary care medical records
Authors: Marshall Michelle , Jordan Joanne L , Bajpai Ram , Nimmons Danielle , Smith Tilli M , Campbell Paul , Jordan Kelvin P
Published: October 2024

Background

Dementia has a major impact on individuals, their families and caregivers, and wider society. Some individuals experience a faster decline of their function and health compared to others. The objective of this systematic review was to determine prognostic factors, measurable in primary care, for poor outcome in people living with dementia.

Methods

Cohort studies set in the community or primary care, and examining prognostic factors for care home admission, cognitive decline, or palliative care were included. Databases were searched from inception to 17th June 2022. Identified papers were screened, the risk of bias assessed using Quality in Prognostic Studies (QUIPS) tool, and data extracted by 2 reviewers, with disagreements resolved by consensus or a 3rd reviewer. A narrative synthesis was undertaken, informed by GRADE, taking into consideration strength of association, risk of bias and precision of evidence. Patient and Public Involvement and Engagement (PPIE) and stakeholder input was obtained to prioritise factors for further investigation.

Results

Searches identified 24,283 potentially relevant titles. After screening, 46 papers were included, 21 examined care home admission investigating 94 factors, 26 investigated cognitive decline as an outcome examining 60 factors, and 1 researched palliative care assessing 13 factors. 11 prognostic factors (older age, less deprived, living alone, white race, urban residence, worse baseline cognition, taking dementia medication, depression, psychosis, wandering, and caregiver’s desire for admission) were associated with an increased risk of care home admission and 4 prognostic factors (longer duration of dementia, agitation/aggression, psychosis, and hypercholesterolaemia) were associated with an increased risk of cognitive decline. PPIE and other stakeholders recommended further investigation of 22 additional potential prognostic factors.

Conclusions

Identifying evidence for prognostic factors in dementia is challenging. Whilst several factors highlighted as of relevance by our stakeholder groups need further investigation, inequalities may exist in care home admission and there is evidence that several prognostic factors measurable in primary care could alert clinicians to risk of a faster progression.

Registration

PROSPERO CRD42019111775.
The effectiveness of unsupervised home-based exercise for improving lower extremity physical function in older adults in Western and Eastern cultures: a systematic review and meta-analysis
Authors: Liang Ian Ju , Perkin Oliver J. , McGuigan Polly M. , Spellanzon Bruno , Robb Molly , Liu Chien-Yu , Lin Linda L. , Thompson Dylan , Western Max J.
Published: October 2024

Background

Ageing leads to decreased physical function, which can impact independent living and raise health risks, increasing demand on healthcare resources. Finding affordable and accessible exercise to improve physical function is necessary for a population seemingly resistant to strength and balance training in leisure settings. This review aimed to evaluate whether unsupervised home-based exercises improve lower extremity function in older adults.

Methods

We systematically searched for randomised controlled trials (RCTs) and cluster RCTs investigating unsupervised home-based exercises’ effects on physical function in older adults through English and Mandarin databases. Studies’ methodological quality was assessed using the Cochrane’s Risk of Bias Tool. Meta-analyses were conducted on lower extremity functions outcomes.

Results

Of the 6791 identified articles, 10 English studies (907 participants) were included, 8 studies (839 participants) were used for final meta-analysis, with no Mandarin studies. Studies were largely based in Europe with mostly moderate risk of bias. Most interventions were multicomponent lasting 10–40 min/session, 3 times/week. Meta-analysis showed no statistically significant differences in 5 sit-to-stand (p = 0.05; I2 = 0%), maximal knee extension strength (p = 0.61; I2 = 71%), 10 m maximal walking speed (p = 0.22; I2 = 30%), timed-up-to-go (p = 0.54; I2 = 0%), and short physical performance battery (p = 0.32; I2 = 98%) between exercise and control groups.

Conclusions

This meta-analysis suggests that unsupervised home-based exercise programmes have little impact on lower extremity functions in older adults. This review is limited by the small number of included studies, sample sizes, and high heterogeneity. There is a need to understand why this format lacks efficacy, and design more beneficial home-based exercise programmes.
Respiratory adverse effects in patients treated with immune checkpoint inhibitors in combination with radiotherapy: a systematic review and meta-analysis
Authors: Ma Zhongjun , Hu Jiexuan , Wu Fei , Liu Naijia , Su Qiang
Published: October 2024

Background

We conducted a systematic review and meta-analysis to assess the risk of respiratory adverse effects in patients with solid tumors treated with immune checkpoint inhibitors (PD-1, PD-L1 and CTLA-4 inhibitors) in combination with radiation therapy.

Methods

We selected eligible studies through the following databases: PubMed, Embase, Cochrane Library, and Clinicaltrials (https://clinicaltrials.gov/). The data was analyzed by using Rstudio.

Results

Among 3737 studies, 26 clinical trials, including 2670 patients, were qualified for the meta-analysis. We evaluated the incidence rates of adverse respiratory events, including cough, pneumonia, upper respiratory tract infections, and others: grades 1–5 cough, 0.176 (95%CI: 0.113–0.274, I2 = 92.36%); grades 1–5 pneumonitis, 0.118 (95%CI: 0.067–0.198, I2 = 88.64%); grades 1–5 upper respiratory tract infection, 0.064 (95%CI: 0.049–0.080, I2 = 0.98%); grades 3–5 cough, 0.050 (95%CI: 0.012–0.204, I2 = 8.90%); grades 3–5 pneumonitis, 0.052 (95%CI: 0.031–0.078, I2 = 83.86%); grades 3–5 upper respiratory tract infection, 0.040 (95%CI: 0.007–0.249, I2 = 45.31%).

Conclusions

Our meta-analysis demonstrated that ICI combined with radiotherapy for solid tumors can produce respiratory adverse effects. ICIs combination treatment, a tumor located in the chest, is more likely to cause adverse reactions, and SBRT treatment and synchronous treatment will bring less incidence of adverse reactions. This study provide insights for clinicians to balance the risks of radiotherapy in the course of treating oncology patients.
Improving working memory by electrical stimulation and cross-frequency coupling
Authors: Al Qasem Wiam , Abubaker Mohammed , Pilátová Kateřina , Ježdík Petr , Kvašňák Eugen
Published: October 2024

Working memory (WM) is essential for the temporary storage and processing of information required for complex cognitive tasks and relies on neuronal theta and gamma oscillations. Given the limited capacity of WM, researchers have investigated various methods to improve it, including transcranial alternating current stimulation (tACS), which modulates brain activity at specific frequencies. One particularly promising approach is theta-gamma peak-coupled-tACS (TGCp-tACS), which simulates the natural interaction between theta and gamma oscillations that occurs during cognitive control in the brain. The aim of this study was to improve WM in healthy young adults with TGCp-tACS, focusing on both behavioral and neurophysiological outcomes. Thirty-one participants completed five WM tasks under both sham and verum stimulation conditions. Electroencephalography (EEG) recordings before and after stimulation showed that TGCp-tACS increased power spectral density (PSD) in the high-gamma region at the stimulation site, while PSD decreased in the theta and delta regions throughout the cortex. From a behavioral perspective, although no significant changes were observed in most tasks, there was a significant improvement in accuracy in the 14-item Sternberg task, indicating an improvement in phonological WM. In conclusion, TGCp-tACS has the potential to promote and improve the phonological component of WM. To fully realize the cognitive benefits, further research is needed to refine the stimulation parameters and account for individual differences, such as baseline cognitive status and hormonal factors.
Sonographic characteristics of thyroid nodules with a Halo
Authors: Cao Danming , Zou Rong , Zhang Ming , Tang Kui
Published: October 2024

Objective

To investigate the sonographic characteristics of thyroid nodules with a halo, explore the value of contrast-enhanced ultrasound (CEUS) combined with fine needle aspiration (FNA) in identifying nodules with a halo, and predict the risk of metastasis by analyzing the pathological features of the halo.

Methods

A retrospective analysis was conducted on 185 postoperative cases of thyroid nodules accompanied by halos between January 2019 and December 2022. After describing the ultrasound characteristics of the thyroid nodules and their halos, all patients were divided into three groups, the first group (group I = CEUS only) of patients underwent CEUS, the second group (group II = CEUS + FNA) underwent FNA based on the first group, and the third group (group III = FNA only) underwent FNA directly. The CEUS and FNA results were graded using the Chinese Thyroid Imaging Report and Data System (C-TIRADS) and Bethesda Reporting System for Thyroid Cytopathology, respectively. Those graded below C-TIRADS 4b or Bethesda IV were defined as benign, and the results of FNA were referenced when the two methods were combined. The surgical pathology results were used as the gold standard. We plotted working curves to compare the diagnostic efficacy of CEUS and FNA alone and in combination in the diagnosis of thyroid nodules with halos. The pathological features of the halo were analyzed and the number of patients with cervical lymph node metastases was recorded.

Results

One hundred and sixty patients met the requirements. Benign nodules were mainly characterized by a thin (0.75 ± 0.31 mm) and uniform halo with good integrity, while malignant nodules had a thicker (1.48 ± 0.51 mm) halo with uneven and irregular margins (P < 0.05). The sensitivity and specificity were highest when the cutoff value was 1.09 mm, with 76.08% and 84.29%, respectively. The halos of benign nodules were mostly hyper- or iso-enhanced, whereas the halos of malignant nodules were predominantly hypo-enhanced (P < 0.05). The areas under the curve (AUCs) for CEUS, FNA, and CEUS + FNA were 0.751(95% CI = 0.642–0.841), 0.863(95% CI = 0.767–0.929), and 0.918(95% CI = 0.834–0.967), respectively. Cervical lymph node metastasis occurred in only 13 (11.5%) malignant nodes with halos. The primary pathological components of the halo around malignant nodules were almost reactive hyperplastic fibrous tissue.

Conclusion

The halo surrounding malignant thyroid nodules is thicker, with uneven and irregular margins, and shows hypo-enhancement on CEUS. Combining CEUS with FNA improves the diagnostic efficacy of thyroid nodules with halos. The reactive hyperplastic fibrous halo may be one of the reasons why malignant nodules are less likely to metastasize.
Break-Pad: effective padding machines for tor with break burst padding
Authors: Huang Bin , Du Yanhui
Published: October 2024

Website Fingerprinting (WF) attacks enable a local eavesdropper to use metadata of packet flow, such as size, timing, and direction, to infer the websites a user is visiting. This can damage the user privacy provided by anonymity systems such as Tor. Tor has implemented the WF defense called Circuit Padding Framework, which provides an interface for developers to implement their own defenses. However, these defenses in the framework were overcome by the Deep Fingerprinting (DF) attack. In this paper, we propose a novel defense approach called break burst padding (Break-Pad), which injects a random number of padding packets into an incoming burst once the number of consecutive incoming packets exceeds a set number. We integrated Break-Pad into the existing Circuit Padding Framework. In addition, we have implemented two padding machines named August and October in the new framework and conducted experiments to evaluate these machines. In the open-world setting, our results show that August, with 29% bandwidth overhead, reduces Tik-Tok’s TPR by 14.48% and DF’s TPR by 22%. October outperforms the best padding machine, RBB. With 36% bandwidth overhead, it drops Tik-Tok’s TPR to 74.24% and DF’s TPR to 65.36%. In the one-page setting, October further reduces the bandwidth overhead by 11% while achieving similar performance to RBB. In the information leak analysis, for the burst sequence feature of the traffic, October leaks at 2.453 bits, while the best comparable padding machine Interspace leaks at 2.629 bits.
Introduction to this special section: Geophysical methods in archaeology
Authors: Krahenbuhl Richard A. , Wilt Michael
Published: October 2024

Archaeogeophysics, i.e., the application and integration of geophysics into archaeological investigations, is an exciting and growing field of study and an international collaboration at the intersection of the physical and social sciences. Through the incorporation of ground- and drone-based geophysical and remote sensing tools, these collaborative teams continue to advance the field of archaeology by rapidly and accurately revealing hidden features of the past and helping to focus active archaeological digs. Equally relevant, yet often unnoticed, the inclusion of noninvasive geophysical tools likewise provides a means to understand and preserve historically and culturally sensitive sites without the need for extensive and potentially destructive excavations.
KNUST SEG Geophysics Field Camp: A project to study slavery-related archaeology in West Africa
Authors: Boateng Cyril D. , Wemegah David D. , Apoh Wazi , Sarpong Vandycke A. , Akingbade James O. , Aning Akwasi Acheampong , Dwomoh Thomas
Published: October 2024

In this article, we describe a field camp in West Africa that explored the use of geophysics in archaeological investigations related to the transatlantic slave trade. Africa's geodiversity and richness of natural resources makes geoscience education essential for social, academic, scientific, and professional growth and development. Field camps serve as a pivotal element of geoscience pedagogy, providing hands-on experiential learning opportunities for budding geoscientists. Due to a lack of funding, there is limited access to and availability of geoscience field camps for students and early-career professionals in Africa. The main goal of our field camp was to delineate archaeological relics related to the transatlantic slave trade in the southeastern part of Ghana. The field camp provided a way to conduct research and train geoscience students in planning and performing geophysical investigations. It also taught students how to process and interpret geophysical data and prepare and present scientific investigation reports. We investigated sites in Aflao, Denu, Hedzranawo, and Keta in the southeastern part of Ghana. Sites of interest included former slave markets, barracoons, and a fort. The project highlighted locations of potential slavery-related archaeological relics and shared the importance of the findings and their implications for understanding the history of transatlantic slavery in Ghana.
Seismic Soundoff: From barriers to belonging — Building strong companies and teams in geophysics
Authors: Geary Andrew
Published: October 2024

Eileen Martin, a recipient of the 2024 J. Clarence Karcher Award, shares actionable advice and resources to help you make a positive impact in your professional environment.
The Trial Enrollment Diversity Dashboard for Acute Leukemia Clinical Research: Intervention Development and Cohort Analysis
Authors: Hantel Andrew , Walsh Thomas P. , Li Kelsey Y. , Awan Saima , Littlejohn Emerald , Lathan Christopher S. , Abel Gregory A.
Published: October 2024

PURPOSE

Participation in acute leukemia clinical trials is inequitable across multiple sociodemographic categories. Tools that provide researchers with performance feedback on the representativeness of the patients they enroll are limited. We aimed to develop an electronic health record (EHR)–based dashboard to provide such feedback and to describe any enrollment inequities uncovered.

METHODS

We created a visual dashboard linking leukemia clinical trial registration and EHR data at the Dana-Farber Cancer Institute. Accuracy of a patient inclusion and assignment algorithm was tested with a target area under the receiver-operator curve (AUROC) of >0.90 against manual review. Demographic metric identification, visualization construction, and dashboard refinement were performed through stakeholder cognitive testing. Analysis of a recent 5-year cohort generated by the final algorithm assessed bivariate associations between enrollment and demographic metrics. Multivariable logistic regression included significant bivariate results.

RESULTS

The final algorithm assignment AUROC was 0.98. Metrics were identified and visualizations successfully constructed. Fourteen individuals participated in testing and identified areas for revision: category mergers, denominator filters, and data delivery preferences. In the initial cohort of 1,315 patients, 1,020 (77.6%) had enrolled in any study protocol: 553 (42.1%) in a treatment trial and 936 (71.2%) in a biobanking study. In a multivariable model, older age (odds ratio [OR], 0.83 [95% CI, 0.73 to 0.94]) and Non-Hispanic Black race-ethnicity (OR, 0.38 [95% CI, 0.18 to 0.82]) were associated with lower enrollment, and English primary language with higher enrollment (OR, 2.50 [95% CI, 1.30 to 4.79]).

CONCLUSION

We developed a research participation equity performance feedback dashboard for clinical researchers, and we identified actionable inequities. Next steps include feasibility and efficacy testing as well as implementation.
Voilà le peuple
Authors: St. Clair Robert
Published: October 2024

Why does it matter that we try to think through, together, as entrammeled with one another, the act and work of reading and “the political”? What is at stake in the question of textuality in the current context of crises and turns-away (from theorization, from critique) that have come to characterize the humanities as the forms and institutions of higher education find themselves increasingly subsumed by the logics and imperatives of neoliberalism? The present article proposes to think through and tarry with this problem by taking as a case study of sorts the reaction of a certain number of literary and cultural studies scholars in the field of nineteenth-century French and Francophone studies to a recent (or perhaps an ongoing) event in the United States and its relation to the mise-en-scène of a revolutionary event in Flaubert’s L’Éducation sentimentale, arguing ultimately that, in dark and disorienting times, literature—which perhaps does nothing so well as help us to grapple with the ways in which the past and the present, and thus any possible futurity, are mutually entrammeled with one another—may help us get certain ideas, if not infallibly right, a little less wrong where possible, where they may matter most.
Proust before Fascism
Authors: Paul Zakir
Published: October 2024

This article analyzes readings of Proust from the 1930s to the 1950s, a period when his work was supposedly forgotten. The first section examines passages by Céline, Kurt Wais, and Curzio Malaparte, for whom Proust’s fiction was symptomatic of the dissipation of the dominant classes. The second part of the essay turns to Benjamin, Bataille, and Blanchot, for whom his novel altered conventional notions of justice, desire, figural language, and the structure of time through the experience of writing. Across the political spectrum, readings of Proust pit the rhetoric of decadence against experience and experiment. The essay concludes that although the Recherche records political, social, and historical events—from the Dreyfus affair and a morphing class structure to the onset of the war—none of these readers saw it as an announcement of disasters to come.
“La destruction est notre manière de bâtir”
Authors: Kim Annabel L.
Published: October 2024

This article examines Quebecois author Kevin Lambert’s debut novel, Tu aimeras ce que tu as tué, a disquieting story of slaughtered children who come back to the Canadian town of Chicoutimi to live normal lives in it before destroying it. The apocalyptic dimension of this tale of destruction lives up to the etymological root of apocalypse, apokalyptein (“to uncover, disclose, reveal” in Greek) by centering the narrative around a revelation of the violence that is inherent to heteronormative culture but occulted by its position of dominance. This violence, which targets the figure of the innocent child, the standard-bearer of heterosexuality in its reproductive futurity, is, through the prophetic rage of the narrator, a child named Faldistoire, turned back upon the respectable adults who stamp out not only the lives of children but their nonnormative desires and impulses—their freedom. The novel puts forth apocalypse as a model for the work of literature itself—revelation that rends normative reality in order to replace it with something else.
Il faut imaginer Pasolini en Cassandre heureuse
Authors: Paquette Julie
Published: October 2024

En 1975, Pasolini raconte l’arrivée imprévisible d’une nouvelle forme de fascisme par la métaphore de la disparition des lucioles. Plus de quarante ans plus tard, Georges Didi-Huberman résume ainsi son propos : « Pasolini [contrairement à Benjamin] a fini par désespérer », rangeant d’un même élan Pasolini du côté des prophètes de malheurs. Une telle lecture paraît contestable. Pour en faire la démonstration, cet article s’attarde sur la figure de Cassandre dans le Carnet de notes pour une Orestie africaine (1970), et montre de quelle manière cette antique prophétesse s’inscrit, par le montage pasolinien, dans la lignée benjaminienne de la tradition des opprimés. C’est donc l’écho d’une Cassandre euripidienne dans l’écriture pasolinienne—tous deux se présentant comme des contemporains au sens où l’entend Agamben—qui ressort au terme de l’analyse, laquelle se conclut en imaginant Pasolini en Cassandre heureuse. Ce qui revient à le réhabiliter dans le champ benjaminien de la tradition de l’organisation du pessimisme.
Mourir, c’est apprendre à vivre . . .
Authors: Julliot Caroline
Published: October 2024

À l’aune de la polémique suscitée par la parution, en novembre 2022, de l’entretien que l’auteur a accordé à Michel Onfray pour sa revue Front Populaire, le présent article tente de réévaluer la posture, construite de longue date dans le discours médiatique, d’un Houellebecq « prophète déprimiste ». Après avoir défendu l’hypothèse que la réactivation, pour le moins anachronique, de la figure de l’écrivain prophète en révèle plus sur la crise du débat démocratique contemporain que sur l’auteur lui-même, il s’attache, notamment par l’analyse du récent roman Anéantir, à nuancer l’univocité du pessimisme qui se dégage de son œuvre. Et si, pour Houellebecq, l’imminence de la mort, de l’individu comme de la civilisation, était, in fine, la condition sine qua non au bonheur ; le seul moyen, dans une société de la compétition et de la performance, de s’extraire du samsara libéral et de sa propre obsolescence programmée pour profiter, simplement, au présent, de la vie ?
La fin du collectif
Authors: Kieffer Morgane
Published: October 2024

Cet article interroge la manière dont trois récits français contemporains, Propriété privée, de Julia Deck (Minuit, 2019), Les États et empires du Lotissement Grand Siècle de Fanny Taillandier (PUF, 2016), et Fabrication de la guerre civile, de Charles Robinson (Seuil, 2016), travaillent le motif de l’Apocalypse en l’ancrant dans une réflexion aux accents ethnologiques et sociologiques autour des territoires périurbains : cités de banlieue et banlieues résidentielles. Dans ces trois textes, à partir d’espaces pourtant bien différents, se développent des hantises partagées : la destruction des modes de vie collectifs comme du sens de la communauté, le repli sur les intérêts individuels dans une perspective du tous contre tous, jusqu’à l’explosion finale, littérale et métaphorique. Si le monde court à sa fin, c’est en banlieue que celle-ci couve.
Denatured Nature
Authors: Scharm Heike
Published: October 2024

This essay places the narrative of the Spanish writer José A. Cano (b. 1954 in Madrid) within the context of contemporary Spanish ecofiction. Concerned with the state of global humanity, Cano reflects a growing postnational perspective among Spanish writers whose works critically address the challenges of the Anthropocene—in particular, the destructive effects the tenets of Western modernity (Kantian ethics, utilitarian values, human-Nature divide, logic of exploitation, dualistic and anthropocentric thought, etc.) have had on the more-than-human world. Heavily influenced by the Romanian philosopher E. M. Cioran, Cano’s novel La felicidad del Malvado (2023) offers a pessimistic outlook regarding the future of humankind. Miguel de Cervantes’s Don Quixote provides another backdrop for this transatlantic novel, situated between the United States and Madrid, allowing Cervantine humor to balance out Cioran’s omnipresent voice of doom.
O “viaduto da controvérsia” em Tucupi: uma reflexão sobre responsabilidade e transparência na administração pública
Authors: Numao Fábio Hideo , Souza João Victor Levinthal Oliveira , Oliveira Luciano Simões , Mendes Luiz Henrique Pereira , Ribeiro Maria Angélica de Jesus
Published: October 2024

Informamos que as notas de ensino dos casos possuem acesso restrito e são exclusivas para docentes e instrutores vinculados à uma instituição acadêmica. Saiba mais.
Enhancing Learning Abilities in Students Using a Cognitive Neuroscience Model Based on Brain-Computer Interface Signal Analysis
Authors: Geddam Rebakah , Khanpara Pimal
Published: October 2024

Computational intelligence is used to create artificially intelligent systems with the ability to learn, adapt, and solve problems. Learners’ computational abilities can be improved with the help of Cognitive Neuroscience techniques. Computational intelligence refers to the ability of a learner based on the complex operations of the brain in the four relevant dimensions: Visual (V), Aural (A), Kinematic (K), and Reading/Writing (R/W). Our proposed framework consists of electroencephalogram (EEG) data acquisition, signal extraction, and EEG signal categorization to assess students’ cognitive learning abilities. Our proposed approach uses an EEG device equipped with a microprocessor, a Think Gear (TGAM) EEG sensor, and a PCB of 16 dry electrodes. The EEG device and the remote processing device are connected by Bluetooth. The EEG signal provides the students with neurofeedback on their cognitive learning capability. The feedback obtained through the learning process will be endowing to improvise computational intelligence. The statistical derivative, Pearson Co-efficient, is used to find the correlation among the derived attributes. The attributes considered are the learner’s gender, stream, age, and geographical region. The results obtained highlight that gender, stream, and age have no correlation with the detectable learning index, and the most accurate learners are kinesthetic ones. Bi-modal learners, who can maintain focus while reading and using their kinematic abilities, had the second highest learning capacity.
Design and Application of Parameter Self-tuning Regulator for DC Motor based on Neural Network
Authors: Yang Xiaodong , Ge Weijing , Wang Yulin
Published: October 2024

This study introduces a cutting-edge approach to regulating DC motors, featuring a unique combination of Artificial Neural Networks (ANN) and Long Short-Term Memory (LSTM) networks. This innovative system capitalizes on the adaptive learning capabilities of ANNs to dynamically fine-tune the control parameters of DC motors. This adaptability ensures optimal motor performance across diverse operational conditions, addressing the challenges posed by fluctuating loads and varying speed requirements. The integration of LSTM networks into this framework adds a layer of predictive functionality, allowing the system to anticipate future motor states. Such foresight enables the regulator to make proactive adjustments, significantly enhancing its responsiveness to changes in operational demands. The dual application of ANN’s adaptive control mechanisms and LSTM’s predictive capabilities is particularly effective in overcoming the non-linearity and variability that are typical challenges in DC motor control. This synergy ensures that the motor operates efficiently, stably, and with a quick response time, even under varying and unpredictable conditions. The practical application of this advanced regulator in real-world scenarios has shown marked improvements in motor performance. These enhancements are evident in the increased efficiency, stability, and responsiveness of the motors, making them more suitable for a wide range of industrial applications. This study marks a notable progression in the field of DC motor control technology. By integrating advanced machine learning techniques, it offers a solution that is not only more efficient and reliable but also adaptable to the evolving demands of industrial environments. The innovative combination of ANN and LSTM networks in this regulator design paves the way for smarter, more responsive, and efficient motor control systems, potentially transforming how motors are managed in various industrial applications.
Construction of Hydrogen Fuel Backup Power Supply System based on Data Communication Technology
Authors: Pan Jun , Feng Keying , Zhuo Yu , Zhang Hang , Ma Tianbao
Published: October 2024

The study presents a comprehensive examination of integrating hydrogen gas cells into backup electricity systems, strengthened by superior records verbal exchange technologies. This modern approach targets to address the growing interest for reliable and sustainable strength sources within the context of developing issues about environmental sustainability and the restrictions of traditional fossil gasoline-based totally power structures. On the middle of this studies is the improvement of a hydrogen gasoline cellular-based totally backup strength device. Hydrogen fuel cells, regarded for his or her excessive strength performance and low environmental impact, offer a promising opportunity to standard energy resources. The device leverages the inherent advantages of hydrogen as a clean strength carrier, making sure reduced carbon emissions and greater energy safety. A giant component of this have a look at is the combination of contemporary data communication generation. This integration facilitates real-time tracking and control of the electricity gadget, ensuring surest performance and reliability. Advanced statistics analytics are hired to are expecting energy demand, reveal gas cell health, and optimize the machine’s operation. This approach no longer handiest complements the performance of the energy supply but also ensures a unbroken transition between the number one energy supply and the backup device at some point of outages. The studies methodology encompasses a blend of theoretical analysis and realistic experimentation. Simulation models are used to test the device’s efficacy underneath numerous scenarios, followed via a prototype implementation to validate the theoretical findings. The look at also explores the monetary viability and scalability of the proposed machine, making it relevant for big adoption.
Algorithm-Enhanced Engineering English Education in the Era of Artificial Intelligence: A Data-Driven Approach
Authors: Li Dongfang
Published: October 2024

The era of artificial Intelligence (AI), the landscape of language training, especially in the vicinity of Engineering English, is gift technique a transformative shift. This paper offers a unique data-driven technique to Engineering English training, stronger via modern day algorithms, to address the precise stressful situations and opportunities furnished through AI enhancements. Our approach integrates algorithmic answers with conventional language coaching methodologies to create a dynamic, adaptive gaining knowledge of environment sustainable-made to the unique wishes of engineering students. Primary method is the usage of AI-driven analytics to investigate students’ language talent and studying patterns. Using leveraging natural language processing and machine mastering algorithms, we are able to customize the curriculum and offer focused practise that aligns with each student’s linguistic and technical level. This consists of the development of specialised vocabulary, comprehension of technical files, and effective verbal exchange in expert engineering contexts. A tremendous element of this study is the collection and evaluation of data on student performance and engagement. This information-driven feedback loop allows non-prevent refinement of coaching techniques and substances, ensuring that the instructional content material cloth remains relevant and effective in the unexpectedly evolving discipline of engineering.
Local Weighted Representation Based Matrix Regression Classifier and Face Recognition
Authors: Shi Fanfeng , Fang Zheng , Wu Xinxin
Published: October 2024

Nuclear-norm-based matrix regression (NMR) approaches utilize the nuclear norm for error term characterization, which strengthens the robustness of algorithm. However, NMR ignores the differences between samples from different classes, which leads to a poor feature representation. Moreover, NMR does not consider variations within different class, which affects the classification performance when classes are not homogeneous. To solve above problems, a local weighted representation-based matrix regression method (LWMR) is proposed. LWMR method solves two issues of current NMR methods that are based on nuclear norm. First, LWMR utilizes the prior distance information between test and training samples as weights, which improves the inter-class separation. Second, LWMR creates a new dictionary by averaging samples within different class and choosing the best representative sample for each class, which reduces the dictionary size and complexity. Experimental results on four widely used datasets demonstrate that LWMR method has faster calculation speed and better image performance than other regression models.
Practical reflection in accounting of transactions taxed at the zero rate of value added tax: the impact of the introduction of separate accounting on the accounting statements of the organization
Authors: Azzheurova Kseniya
Published: October 2024

The article discusses the specifics of applying the zero value-added tax rate, taking into account the changes that occurred in 2024 in the order of its application in the implementation of relevant operations. In the paper, the author substantiates that if earlier the 0% rate was primarily an "export" rate, now the list of activities subject to taxation at this preferential rate is increasing. Consequently, the number of organizations that will have to implement accounting methods based on the requirements of regulatory tax authorities is also increasing, which will have a significant impact on the established accounting and tax accounting procedures within the company.
Asymmetry and Imbalance in Trade between East and West in the 1980s
Authors: Klimiuk Zbigniew
Published: October 2024

An analysis of the development of East-West trade in the 1980s and earlier allows us to draw a conclusion about the imbalance in the importance of mutual economic relations at that time. This imbalance was multi-faceted and manifested itself in, e.g., imbalance in the structure of trade in goods, payment asymmetry, as well as various motives of OECD and Comecon countries when making decisions on mutual exchange. The imbalance in the commodity structure of the East-West mutual trade reflected the fact that complementary goods were exchanged instead of, as was the case in countries characterized by a modern exchange structure, substitute products. The complementary nature of East-West trade meant that the exports of the socialist countries to the markets of the Western countries encompassed, to a large extent, different commodity groups than the imports of the Comecon countries from this area. While exports from socialist countries consisted mainly of goods with a relatively low degree of processing, the exports of capitalist countries to their Eastern partners encompassed mainly finished products with a significant degree of processing and the involvement of modern technological thought.