bluuebunny/crossref_metadata_2025 huggingface dataset:
ÇALIŞANLARDA POZİTİF SES ÇIKARTMANIN İŞTEN AYRILMA NİYETİNE ETKİSİNDE LİDER ÜYE ETKİLEŞİMİNİN ARACI ROLÜ
Authors: ALİ Falis Abshır , DARICAN Şule
Published: August 2023

Amaç: Sağlık çalışanları üzerinde yapılan bu çalışmanın amacı, pozitif ses çıkartmanın işten ayrılma niyeti üzerine etkisinde lider-üye etkileşiminin aracı rolünü belirlemektir.
Yöntem: Çalışmanın evrenini İstanbul’da hizmet veren özel bir hastanede çalışan 450 sağlık personeli oluşturmaktadır. Araştırma sonucunda elde edilen verilere yönelik açıklayıcı faktör analizi (AFA) ve ölçeklerin yapı geçerliliği için doğrulayıcı faktör analizi (DFA) yapılmış, uyum iyilikleri olumlu sonuç vermiştir. Ölçüm modeline göre, ilişkilerin belirlenmesine yönelik yapısal eşitlik modeli (YEM) uygulanmış ve sonuçlar değerlendirilmiştir. Araştırmada ana boyut ve alt boyut ilişkilerinin belirlenmesi amaçlı korelasyon analizi uygulanmıştır.
Bulgular: Çalışmada elde edilen sonuçlara göre; pozitif ses çıkartma boyutu işten ayrılma niyetini istatistiksel olarak negatif yönde anlamlı %42,1 etkilerken, pozitif ses çıkartma boyutu lider-üye etkileşimini pozitif yönde anlamlı %39, etkilemektedir. Öte yandan, lider-üye etkileşimi boyutu işten ayrılma niyetini negatif yönde anlamlı %33 etkilemektedir.
Sonuç: Araştırmada, sağlık sektörün de pozitif ses çıkartma davranışı arttıkça işten ayrılma niyetinin azalacağı sonucuna ulaşılmıştır. Aynı zamanda çalışanların fikirlerini paylaşımında liderleri ile olan ilişkinin samimiyetinin işten ayrılma niyeti üzerinde önemli bir katkı sağladığı görülmektedir.
Production of Biodiesel Using Enzymatic Esterification of Multi-Feedstock Oils
Authors: Sumatri Indro , Hadiyanto H. , Suherman S. , Christwardana Marcelinus
Published: August 2023

Biodiesel is produced from oils esterified with alcohol into glycerol and water. Vegetable edible oil raw materials are the main consideration in biodiesel production. This study used three types of oil, namely palm oil (PO), waste frying oil (WFO), soybean oil (SO), and corn oil (CO), with the catalyst of the enzyme lipase. The price of WFO as raw materials is low, although it must be controlled acid and water levels. In the research run, the oil mixture consists of two types of oils mixed with a certain composition and the addition of certain lipase enzymes. The research resulted that the yield produced by multi-feedstock biodiesel with free fatty acid (FFA) < 2 was 89.7%, 89.03%, and 86.11% higher than the sample with FFA > 2 at 79.54%, 74.66%, and 73.33%, respectively. The minimum density produced is a mixture of WFO with CO of 861.1 kg/m3. The largest viscosity produced is a mixture of WFO with SO of 18.03 mm2/s. Mixing raw materials can lower the number of iodine multi-feedstock biodiesel. The number of acids produced by multi-feedstock biodiesel exceeds ASTM standards. The total glycerol produced by multi-feedstock biodiesel varies, whereby a multi-feedstock blend of PO can lower total glycerol. In contrast, a multi-feedstock blend of WFO tends to produce high total glycerol.
Enhancing the Anti-Fouling Property of Polyethersulfone-based Membrane using Chitosan Additive from Golden Snail (Pomacea canaliculata) Shell Waste for Water Purification
Authors: Mulyati Sri , Rosnelly Cut Meurah , Syamsuddin Yanna , Arahman Nasrul , Muchtar Syawaliah , Wahyuni Wahyuni , Lauzia Tiara , Ambarita Aulia Chintia , Bilad Muhammad Roil , Samsuri Shafirah
Published: August 2023

One of the common techniques for treating water and water from waste effluent is membrane filtration. Polymer is the main material that is most extensively employed as a substance for membranes. Because of its outstanding strength and resistance to chemicals, Polyethersulfone, also known as PES, is a common polymer used in the production of membranes. Unfortunately, its hydrophobicity makes it easy to foul when applied to water treatment processes. This study introduced a chitosan additive isolated from golden snail shell waste as an additive for PES-based membrane fabrication via blending at 0 wt%, 1 wt%, 3 wt%, 5 wt%, and 7 wt%. After preparation, the resultant membranes were analyzed and tested for their ability to filter a humic acid solution at a concentration of 50 mg L-1. According to the findings, the chitosan additive has the potential to change the characteristics of the membrane as well as its filtration performance. It increased the pure water flux from 110 181 L m-2 h-1 (no chitosan loading) to 181 L m-2 h-1 (for five wt% loadings). The membrane characterization results supported this increase in pure water flux, which showed that adding chitosan additives improved the porosity, size of pores, and hydrophilicity. The addition of this additive also has a good effect on the anti-fouling property by increasing the fouling recovery ratio (FRR). The FRRs for the modified membranes were 79% to 82%, which were higher than the neat PES membrane with an FRR of merely 60%.
Social Capital and the Role of Resilience in its Development
Authors: Saberifard Nima , Taleghani Mohammad , Zinati Babak
Published: August 2023

It has always been of special importance during different periods of quality of life and its improvement for people and societies. Improving the quality of life reflects the living conditions and well-being of people. There are different factors involved in getting this important. Factors such as socio-economic status, environmental status and social capital. Social capital is a subject that seems to have received less attention. Social capital, which is considered as an intangible capital, leads to an increase in the quality of life and will lead to prosperity in general. One of the ways to achieve its development is to increase resilience. In this research, after the introduction, with a review of the theoretical foundations related to the topics of social capital and resilience and the research that has been done in this field, it has been tried to determine its importance as much as possible, and finally, after the discussion and conclusion, some suggestions have been proposed.
A Brief Linguistic-stylistic Analysis of MY LIFE and SOMEONE I’M AFRAID OF
Authors: Wang Min
Published: August 2023

Linguistic devices in poetry have always been a research hotspot in the field of literature. Combined with important linguistic devices, the researcher made an attempt to compare and discuss the systematic stylistic functions between the poem MY LIFE and the poem SOMEONE I’M AFRAID OF. More specifically, two research questions are addressed: which linguistic features are used to achieve the foregrounding in the poem to support the theme? And what is the functional significance of these linguistic devices from the stylistic point of view? This paper first identified and classified the linguistic devices employed by these two poems for theme foregrounding. Then this paper analyzed and discussed the functions and the meaning implications produced through those linguistic features. The analysis of these two poems finds that metaphor, repetition, parallelism, simile, and personification are more prominent linguistic devices that are used to allow the poets to create literary plays, reiterate visual images, convey emotional tension, enhance emotive cohesion, stimulate emotional resonance and add literary color. The research finds that these different functional effects can be reflected by the same linguistic devices, also by using different linguistic devices, which mainly depends on the poet’s flexible use of these linguistic techniques.
Using LMS “Elsakti’ as an Effective Assessment Medium for English EFL Learning
Authors: - Taufiqulloh , Nindya Meyga Agustia , Rosdiana Ihda
Published: August 2023

This study was carried out to seek information on the roles of Elsakti as a medium of assessment in English EFL learning focusing on the opportunities and challenges perceived by EFL learners. It employed a case study research using the interview to obtain in-depth and detailed information from the participants. Six EFL learners of Universitas Pancasakti Tegal were involved in this study conducting telephone interviews. This result reveals that Elskti has been found to support digitalization where students as well lecturers have higher chances to optimally use digital tools to help them work with assignments and other work more effectively and efficiently. Its features also have essential roles as a medium of assessment in language teaching as they facilitated the creation of a fun learning environment, practicality, automated scoring, and direct feedback. The findings of this study also designate that Elsakti is powerful and potential to be utilized to implement formative assessment more often since it plays important roles in the EFL learning and teaching process, including formative assessment. Meanwhile, the challenges perceived by participating learners in this study were majorly related to the technical problems that the learners did not encounter often or at every meeting.
Produção de vídeos e o uso do GODP para a orientação de profissionais de TI
Authors: Felix Josemar Coelho , Failache Mauricio José Vera
Published: August 2023

Este estudo teve como objetivo aplicar o Guia de Orientação para o Desenvolvimento de Projetos (GODP) na prática de produção de conteúdo para orientação profissional. Para tanto, foi realizada uma pesquisa aplicada quali-quanti e de cunho descritivo a partir da qual, através de uma interligação entre a pesquisa bibliográfica e a pesquisa-ação, foi possível desenvolver vídeos para a plataforma YouTube. Inicialmente, realizaram-se estudos referentes a empresas associadas a um laboratório universitário, e, na sequência, as informações obtidas foram cruzadas com as características dos discentes que compunham o ambiente acadêmico. Posteriormente, criaram-se proposições e informações para a construção do conteúdo das profissões de “product designer” e gestor de projetos ágeis. Os resultados apontaram que o GODP, aplicado à prática projetual da produção de conteúdo digital, auxiliou na compreensão do mercado de trabalho e das principais características de dois perfis profissionais que são destaques na área de tecnologia da informação. Concluiu-se, portanto, que utilizar a prática citada permitiu a obtenção de informações relevantes que facilitam a construção de futuros profissionais.
Pre-procesamiento de datos educativos desde un enfoque de dominio específico.
Authors: Hernández-Leal Emilcy Juliana , Costa-Rocha Juary , Duque-Méndez Néstor Darío
Published: August 2023

Los procesos de análisis de datos requieren preprocesamiento antes de la aplicación de técnicas o algoritmos, con el fin de incrementar la calidad de estos y adecuarlos a los formatos necesarios para su procesamiento, principalmente cuando los datos provienen de diferentes fuentes. El presente artículo expone la experiencia en el diseño y construcción de una estrategia con enfoque de dominio específico para el proceso de preparación de datos educativos. La metodología del estudio incluyó tres etapas: (1) diseño y construcción de la estrategia para preparación de los datos educativos, (2) reconocimiento y selección de datos y (3) aplicación de la estrategia y revisión de resultados. El caso de estudio estuvo conformado por datos provenientes del sistema de educación básica y media del departamento Norte de Santander (Colombia). Se contó con datos referentes al proceso de matrícula, los cuales incluyen variables de tipo socioeconómico y familiar y con datos de valoraciones de desempeño académico de estudiantes provenientes de tres instituciones educativas de carácter público. Para las dos fuentes se procesaron datos de los años 2014 a 2018, con un total de más de ochocientos mil registros. Este trabajo aporta valor en tres aspectos principalmente: el alcance respecto al nivel educativo de dónde provienen los datos del caso de estudio, la inclusión del enfoque de dominio específico en la solución y la centralización de los datos de las múltiples fuentes, resultando datos disponibles para posteriores procesos de análisis. En conclusión, este trabajo contribuyó tanto en el ámbito investigativo como en la aplicación del conocimiento en un caso existente y abrió la posibilidad de realizar pruebas posteriores con otro tipo de datos del contexto educativo.
Clasificación y formulación de hipótesis: un estudio descriptivo de la variabilidad en dos situaciones de resolución de problemas en niños y niñas en edad preescolar
Authors: Castillo Ospina Jennifer
Published: August 2023

El presente artículo tiene como objetivo analizar el desempeño de 20 niños y niñas en edad preescolar en dos tareas de resolución de problemas que involucran el uso de la clasificación y la formulación de hipótesis respectivamente. Los participantes tienen entre 4 y 5 años, escolarizados en un jardín infantil en el municipio de Florida, Valle, Colombia. Con los resultados se evidenció que el uso que los niños y niñas en edad preescolar hacen de estos funcionamientos cognitivos no está limitado por la edad, ni por una estructura lógica que los defina, sino que utilizan diversas estrategias en la resolución de una misma tarea. Es el caso de la clasificación en donde usaron una gran variedad categorías, basadas en criterios conceptuales y perceptuales. En cuanto a la formulación de hipótesis, los participantes mostraron que tienen diversas explicaciones para un mismo fenómeno, ya que la evidencia física no fue el factor determinante en su desempeño, sino que usaron también sus experiencias previas para formular sus hipótesis. De esta manera se concluye que la variabilidad está estrechamente relacionada con el cambio, ya que es un fiel indicador empírico, explícito y visible de la naturaleza del cambio cognitivo.
Sistematización de la experiencia sanarte: un servicio en salud y bienestar integral en la comunidad educativa UNAD
Authors: Roa Naindu Alonso , Jurado Briceño Gina Marcella , Bolena Rodríguez Ana , Aguirre Valencia Sandra Inés
Published: August 2023

La sistematización de experiencias permite realizar una interpretación crítica de SanArte: servicio de salud y bienestar integral de la Universidad Nacional Abierta y a Distancia – (UNAD), como referente en la implementación de servicios de salud en instituciones educativas en Colombia. Así como explicar el proceso vivido, los diversos factores que intervinieron y las relaciones entre sí. Las denominadas medicinas tradicionales, alternativas y complementarias (MTAC), o no convencionales han venido adquiriendo mayor demanda en la oferta de servicios terapéuticos en el mundo. Aunque por ahora no se conoce una forma única en la implementación de las MTAC, se observa que ser de mente abierta y generar diálogos de saberes es la mejor disposición para potenciar estas prácticas siendo un medio tan complejo, diverso y en permanente transformación. SanArte como espacio de servicio en el entorno de la UNAD ayuda a la comunidad educativa en la preservación y restablecimiento de la salud, integrando el componente físico, emocional y mental para que a través del uso y aplicación de terapias alternativas y la identificación de elementos de autocuidado se logre el equilibrio y el bienestar.
First-order periodic coupled systems with generalized impulse conditions
Authors: Perestrelo Sara , Minhós Feliz
Published: August 2023

We present some existence and localization results for periodic
solutions of impulsive first-order coupled non-linear systems of two
equations, without requiring periodicity for the nonlinearities. The
arguments are based on Schauder’s Fixed Point Theorem together with the
upper and lower solution method, where the upper and lower solutions are
not necessarily well-ordered. In addition, results on equi-regulated
functions are required for the impulsive analysis. An application to a
Wilson-Cowan system of two strongly coupled neurons illustrates one of
the main results.
Verifiable privacy preservation scheme for outsourcing medical image to cloud through ROI based crypto-watermarking
Authors: Zhou Yi , Zhou Chuan , Liu Yan , Wang Min , Liu XiangZhi
Published: August 2023

A novel verifiable privacy preservation scheme for outsourcing medical
image to cloud through ROI based crypto-watermarking is proposed in the
paper. In the proposed scheme, data owner firstly carries out
substitution of S-box for the region of interest (ROI) of medical image,
and then separates the image into 4 most significant bits (MSBs) plane
and 4 least significant bits (LSBs) plane images. Secondly, the hash
value of ROI is embedded into the two separated bit plane images using
reversible watermarking algorithm. Lastly, some selected hash values are
transformed into the initial parameters of chaotic maps, and the two
sharing secrets, which are produced through chaos based encryption
algorithm, are finally outsourced to two different cloud servers. For
authorized users, they can get shares from different cloud servers, and
then can losslessly recover the original medical image through a series
of decryption operations and extraction of watermarking. Furthermore,
the users can verify whether the original image is completely
reconstructed or not, they even can locate the tampered parts inside ROI
if anyone of the sharing secrets is damaged. Some experiments analyses
and comparisons are given to show the security and effectiveness of
proposed scheme.
Evaluation of patient satisfaction with provided spinal anesthesia for Cesarean delivery: A survey in Leskovac General Hospital, Serbia
Authors: Pejcic Nada , Mitic Radomir , Gavrilovic Slobodan , Jovic Marija , Krusic Slavica , Pujic Borislava , Velickovic Ivan , Sadana Neeti
Published: August 2023

Introduction/Objective. ?o ensure that all patients receive the best possible anesthetic care, it is essential to continuously evaluate our practices and strive for improvement. The objective of this study was to internally assess the anesthesia services provided during the peripartum period. Methods. The Anesthesiology Department of Leskovac General Hospital, Serbia (LGH) aimed to evaluate patient satisfaction with spinal anesthesia (SA) for Cesarean delivery (CD) using a questionnaire consisting of four open-ended questions. Following Institutional Review Board approval, an institutional-based survey was conducted from August 2021 to July 2022. During the study period, 624 (40.6%) of the total 1535 deliveries in LGH were CDs, with 311 (49.8%) of them performed under SA. Of the patients who underwent CD under SA, 87 agreed to anonymously complete the questionnaire. Results. Although patients had sufficient space to provide detailed responses, the majority of participants opted for brief answers, often limited to ?yes? or ?no?. Of the surveyed participants, 78% were informed about SA for CD before delivery, and 96.6% expressed satisfaction with the information provided during the preoperative anesthesiologist?s visit. Additionally, the majority of participants (94.3%) reported satisfaction with the postoperative analgesia they received. Conclusion. Our patients expressed high levels of satisfaction with the preoperative anesthesiologist?s visit and the SA provided for CD. However, there is a need to improve antenatal education for expectant mothers in the field of anesthesia. Conducting a new and more detailed survey would be necessary to further explore the influence of patient education and socio-economic status on patient satisfaction.
Nickel sensitization and detergents.
Authors: Malten KE , Schutter K , Van Senden KG , Spruit D
Published: August 2023

No abstract available
Nummular eczema--clinical and statistical data.
Authors: Hellgren L , Mobacken H.
Published: August 2023

Abstract is missing
Use of a kallikrein inhibitor in the treatment of urticaria and hereditary
Authors: Juhlin L , Michaëlsson G.
Published: August 2023

No abstract available
New light microscopic skin findings in Fabry's disease. Study of four patients
Authors: Tarnowski WM , Hashimoto K.
Published: August 2023

No abstract available
Oral provocation in eczematous contact allergy to neomycin and
Authors: Ekelund AG , Möller H.
Published: August 2023

No abstract available
Proteolytic enzymes in the skin. II. A comparative study of skin homogenates of
Authors: Jansén CT , Hopsu-Havu VK.
Published: August 2023

No abstract available
Long term prognosis of chronic paronychia.
Authors: Gamstedt A , Juhlin L , Lidén S.
Published: August 2023

No abstract available
Cross-sensitization between synthetic primin and related quinones.
Authors: Hjorth N , Fregert S , Schildknecht H.
Published: August 2023

No abstract available
Unusual granulomas of the skin seen in Lebanon
Authors: KH Kaidbey , AK. Kurban
Published: August 2023

No abstract available
Scleredema Buschke
Authors: H Hammar , L. Juhlin
Published: August 2023

No abstract available
Oral ampicillin in uncomplicated gonorrhoea. 3. Results of treatment in women with positive rectal culture
Authors: G. Eriksson
Published: August 2023

No abstract available
Superficial disseminated eruptive form of porokeratosis mibelli on nonactinic skin areas
Authors: KM. Niemi
Published: August 2023

No abstract available
Porphyria cutanea tarda due to colchicine in a patient with gout
Authors: K. Kuokkanen
Published: August 2023

No abstract available
A gravimetric technique for the analysis of acute ultraviolet damage
Authors: JD Nash , RM. Fusaro
Published: August 2023

No abstract available
Formaldehyde-induced fluorescence of epidermal melanocytes after a single dose of ultraviolet irradiation
Authors: G Agrup , B Falck , H. Rorsman
Published: August 2023

No abstract available
Malignant disease in dermatitis herpetiformis
Authors: T. Månsson
Published: August 2023

No abstract available
Erythropoietic protoporphyria
Authors: G Hovding , OI Haavelsrud , N. Wad
Published: August 2023

No abstract available
Trimethoprim-sulphamethoxazole in gonorrhoea
Authors: S Ullman , AM Niordson , H. Zachariae
Published: August 2023

No abstract available
Presence and properties of tyrosinase in sera of melanoma-bearing animals
Authors: HF Haberman , IA. Menon
Published: August 2023

No abstract available
Cell transition in human sebaceous glands
Authors: G Plewig , E Christophers , O. Braun-Falco
Published: August 2023

No abstract available
Erythrasma and pruritus ani
Authors: A Bowyer , I. McColl
Published: August 2023

No abstract available
Abnormal cutaneous reactions to a nicotinic acid ester
Authors: L Juhlin , G. Michaëlsson
Published: August 2023

No abstract available
Acrodermatitis chronica atrophicans and malignant lymphoma
Authors: M. Goos
Published: August 2023

No abstract available
Continuous skin perfusion in vivo as a method for study of pharmacological agents in human skin
Authors: Greaves MW. , Sondergaard J.
Published: August 2023

No abstract available
Palmar and plantar keratoderma with hyperpigmentation and gynecomastia. Report of a case associated with primary adenocarcinoma of the lung
Authors: Riddick LR , Brodkin RH , Gibbs RC
Published: August 2023

No abstract available
Demonstration of neisseria gonorrhoeae in prostatic fluid after treatment of uncomplicated gonorrhoeal urethritis
Authors: Danielsson D. , Molin L
Published: August 2023

No abstract available
Modulation of collagen metabolism in cultured human skin fibroblasts by dexamethasone: correlation with glucocorticoid receptor density
Authors: Oikarinen A , Oikarinen H  , Tan EM , Uitto J
Published: August 2023

Connective tissue metabolism was studied in detail in three human skin fibroblast lines, demonstrating low, medium, or high levels of glucocorticoid receptor densities. In the cell lines with low and medium receptor density, dexamethasone, in the range of 10(-5)-10(-9) M, had no effect on collagen production, using short incubation time periods and high (20%) fetal calf serum concentration, while in the cells with highest receptor density, a slight stimulation of collagen synthesis was noted in the concentration range 10(-6)-10(-9) M. In the presence of low concentration (0.5%) of serum, dexamethasone markedly inhibited collagen production. The production of collagenase, assayed by degradation of 3H-labelled type I collagen substrate with a brief trypsin activation of the enzyme, was reduced in a dose dependent manner in all 3 cell lines, the inhibition with 10(-5) dexamethasone being up to 56% of the control. Similarly, the activity of an elastase-like neutral protease was decreased in the presence of dexamethasone. Thus the results indicate that glucocorticoids may have profound effects on the degradation of connective tissue components, while the effects on collagen synthesis may be more variable depending on the environmental milieu.
Transcutaneous PO2 and laser Doppler blood flow measurements in 40 patients with venous leg ulcers
Authors: Sindrup JH , Avnstorp C  , Steenfos HH , Kristensen JK
Published: August 2023

The study included 40 patients with clinically venous leg ulcer(s) in one leg only and with a systolic toe blood pressure above 50 mmHg in both legs. Transcutaneous oxygen tension was measured on both lower legs at equivalent sites, on the affected leg immediately proximal to the ulcer(s). Similarly, skin blood flow was measured in both legs at a skin temperature of 32 degrees C and 44 degrees C by means of laser Doppler velocimetry, and for each leg the index of blood flow 44 degrees C/flow 32 degrees C was calculated to express the degree of blood flow increment following local hyperthermia. Transcutaneous oxygen tension measurements were significantly lower on affected legs (p less than 0.01) as was flow increment (p less than 0.01), mainly due to a high flow measurement at 32 degrees C on affected legs rather than to a low measurement at 44 degrees C. The results of our flow measurements suggest a state of (relative) hyperemia in the vicinity of venous leg ulcers, also confirmed by the clinical findings. This could be interpreted as an arteriolar response to lowered oxygen tension or (it could) be part of reactive reparative processes leading to increased O2 consumption in the tissues.
An analysis of infiltrating cells in human ringworm
Authors: Sugiura H , Uehara M  , Watanabe S
Published: August 2023

Immunohistochemically we examined six patients with ringworm which exhibited a well-marked erythematous edge and central resolution. To obtain a panoramic view of the immunopathological features of various evolutionary stages of skin lesion, we took a radial slice biopsy specimen extending from normal-appearing skin to central resolution. The actively involved edge had a moderate amount of dermal infiltrate of mononuclear cells which mostly consisted of T cells. The ratio of the helper T cells to suppressor T cells was 3.4. At the central resolution, the dermal infiltrate was mild, and the helper T/suppressor T ratio was 3.0. The well-marked erythematous edge showed a decrease of OKT6 positive Langerhans´ cells in the epidermis, while many OKT6 positive cells were present in the upper dermis. At the central resolution, however, OKT6 positive cells increased in number in the acanthotic epidermis.
A comparative study on peripheral blood lymphocyte subpopulations in different kinds of warts
Authors: Lodi A , Betti R  , Cattaneo M , Rosti A  , Masnada MC , Marmini A , Crosti C.
Published: August 2023

Peripheral blood T-cell subpopulations were evaluated in 36 patients with clinically different types of warts, subdivided in 4 groups (common, genital, flat and plantar warts). A significant decrease was found in OKT3 and OKT4 subsets total count and in OKT4/OKT8 ratio in patients with common and genital warts as compared with controls. Only in common and genital warts did we also observe a significant decrease of percentage of OKT4 subset. No significant difference of considered parameters was observed in flat and plantar warts as compared to controls, apart from a significant increase in number of OKT8 subset in flat warts. We then discuss this different status of C.M.I. in patients with different clinical warts, stressing the importance of various types of HPV.
Arotinoid ethyl ester (Ro 13-6298): a long term pilot study in various dermatoses
Authors: Mérot Y , Camenzind M  , Geiger JM , Saurat JH
Published: August 2023

The arotinoid ethyl ester Ro 13-6298 is a third generation retinoid shown to be thousand-fold more potent than etretinate (Tigason, Tegison) in animal testing and in human therapy. In an open uncontrolled trial, we treated 57 patients suffering from psoriasis (32) and various severe skin disorders (25) with daily doses ranging from 20 to 150 micrograms, during 1 to 130 weeks (mean = 12 weeks). Four patients were treated for 1 year or more. Given in micrograms per kg range, Ro 13-6298 showed a spectrum of clinical activity and mucocutaneous side effects similar to that of etretinate given in mg per kg range. One patient developed diffuse idiopathic skeletal hyperostosis after 2 years of continuous therapy. No increase in either serum triglycerides or cholesterol levels was observed, even in patients treated for 33 to 130 weeks. This might prove to be an advantage of this new retinoid. Furthermore, this series suggests that potent mucocutaneous (therapeutical and side) effects are not necessarily linked to all other signs of retinoid toxicity.
Immunological studies in chronic mucocutaneous candidiasis before and after ketoconazole treatment
Authors: Mobacken H , Lindholm L  , Moberg S
Published: August 2023

Immune functions were studied in eight patients with chronic mucocutaneous candidiasis representing a broad clinical spectrum of this disease. Clinical improvement after ketoconazole for 6 months was not associated with amelioration of cutaneous delayed hypersensitivity to Candida antigen or the in vitro lymphocyte responses to Candida antigen of T-cell mitogens.
Relationship of dietary gluten intake to dapsone dose in dermatitis herpetiformis
Authors: Mobacken H , Andersson H  , Dahlberg E , Kastrup W
Published: August 2023

The gluten intake was quantitated utilizing a dietary history method in 43 patients with dermatitis herpetiformis on non-restricted diet. The mean daily gluten intake was 15 g. The individual intake of gluten was related to the maintenance dose of dapsone. It was significantly higher in patients on 100-150 mg dapsone daily than in those taking 0-25 mg daily. There was a significant correlation between amount of gluten in the diet and the dapsone dose (p less than 0.01, rs = 0.43). Villous atrophy was not related to the dapsone dose. It is suggested that the gluten-sensitive enteropathy changes the intestinal permeability and thus contributes to the development of blisters.
Polymorphonuclear leukocyte chemotaxis in generalized pustular psoriasis
Authors: Zelickson BD , Pittelkow MR  , Muller SA , Johnson CM
Published: August 2023

We studied polymorphonuclear leukocyte (PMNL) chemotaxis in 3 patients with generalized pustular psoriasis using 3 chemoattractants: Zymosan-activated serum from both the patients and normal individuals, and n-formyl-methionyl-leucyl-phenylalanine (FMLP). These attractants were assayed against both patient-derived and normal PMNLs. All patients had quiescent skin disease at the time of assay. We found that all patients had decreased PMNL chemotaxis to autologous Zymosan-activated serum, but not to FMLP. PMNLs from normal individuals responded normally to serum from the patients. We conclude that patients with generalized pustular psoriasis, when free of symptoms, may have an isolated PMNL chemotactic defect that is restricted to serum-derived attractants.
Fungal infections occurring under bandages in leg ulcer patients
Authors: Hansson C , Faergemann J  , Swanbeck G
Published: August 2023

In 49 consecutive leg ulcer patients fungal cultures were taken from 4 different locations: the ulcer; the ulcer edge; 10 cm below the knee; and the toe-web. The patients had been treated with ACO Medicated Stockings in half of the cases, and the others were treated with several different bandages. Sera were analysed for antibodies against Candida albicans with the indirect immunofluorescence technique (IIF). The mean antibody titer was 434 in the patients with C. albicans in their ulcers, 123 in control patients with negative cultures in their ulcers and 258 in control patients with basalioma or actinic keratoses. Seven patients were culture positive for C. albicans, two patients had C. parapsilosis and one had growth of Trichophyton rubrum in their ulcers. Nine out of 10 patients with positive cultures had been treated with ACO Medicated Stockings (p less than 0.05). Covering a large area of the leg with an ointment impregnated stocking without preservatives seems to increase the risk for fungal infections.
Effect of androgenic and anabolic steroids on the sebaceous gland in power athletes
Authors: Király CL , Alén M  , Rahkila P , Horsmanheimo M
Published: August 2023

The effect of androgenic and anabolic steroids on sebaceous gland activity and the composition of sebum was studied in power athletes. The subject self-administered large doses of androgenic and anabolic hormones during a 12-week-period of strength training. After 4 weeks of administration of hormones the sebum excretion rate increased significantly (p = 0.002) and it remained high throughout the period of exogenous steroid use. The amounts of cholesterol were significantly increased during that period. There were no differences in the amounts of the following lipid groups; free fatty acids, squalen, triglycerides, wax esters, diglycerides and paraffins. It was concluded that large doses of androgenic and anabolic steroids lead to an increase in sebum output in healthy young adult males.
Ultrastructural aspects of skin after cryoultramicrotomy
Authors: Pautrat G , Bernerd F  , Morel G , Ortonne JP  , Hensby C
Published: August 2023

Skin was studied by transmission electron microscopy after cryoultramicrotomy. Global and ultrastructural preservation of the tissue was obtained with satisfactory cohesion between dermis and epidermis. The main constitutive elements could be observed with good definition allowing easy recognition of all the organelles and therefore absolute identification of each cellular type encountered. The methodology provided a comparable quality to the conventional technique. Ice crystal artefacts were minimized but slight enlargement of intercellular spaces persisted. One of the main advantages of this procedure is that neither lipidic solvents nor embedding resins, are used, so that one can envisage cytochemical studies.
Experimental folliculitis with Pityrosporum orbiculare: the influence of host response
Authors: Goodfield MJ , Saihan EM  , Crowley J
Published: August 2023

The aetiology of the folliculitis associated with seborrhoeic eczema is unclear, though the yeast, Pityrosporum orbiculare has been implicated. P. orbiculare was applied under occlusion to normal forearm skin of patients with seborrhoeic eczema (SE), seborrhoeic eczema and folliculitis (SEF), and normal controls. There were significant differences in response to occlusion between the three groups. Those patients with previous clinical evidence of folliculitis (SEF) developed folliculitis at the site of occlusion more frequently than either of the other two groups (p less than 0.001), in whom only one patient developed skin changes. This difference was not explained by the response to occlusion alone, nor by natural carriage of yeasts. These results suggest that the yeast P. orbiculare is necessary for the development of folliculitis, but that the nature of the host response determines those patients prone to follicular inflammation.
Are acquired nevi oestrogen-dependent tumours?
Authors: Jemec GB , Bhogal BS  , Wojnarowska F
Published: August 2023

Twelve benign acquired nevi were studied for the possible specific binding of the ER D5 monoclonal antibody. The ER D5 monoclonal antibody identifies the p29 protein, which is found in the cytoplasm of oestrogen-sensitive cells and which is present in a higher concentration than nuclear oestrogen receptors. No staining was seen in nevoid cells, and the results are taken to support the hypothesis that acquired nevi are not oestrogen-dependent tumours.
Enhanced releasability of prostaglandin E2 and leukotrienes B4 and C4 from leukocytes of patients with atopic eczema
Authors: Ruzicka T , Ring J.
Published: August 2023

The releasability of arachidonic acid-derived inflammatory mediators (eicosanoids) from peripheral blood leukocytes has been tested in patients with atopic eczema and healthy, non-atopic controls. Spontaneous and stimulated release of prostaglandin E2 (PGE2), leukotriene B4 (LTB4) and leukotriene C4 (LTC4) has been measured after challenge of cells with various concentrations of anti-IgE, Ca-ionophore A23187 and C5a. The maximal stimulation of cells with Ca-ionophore resulted in the generation of high amounts of all eicosanoids, which was essentially equal in both atopic and control groups. On the other hand, enhanced spontaneous and stimulated eicosanoid release was noted after immunological challenge using C5a and anti-IgE in the atopic eczema group. Thus, our data support the hypothesis of enhanced releasability of inflammatory mediators in atopic eczema.
Papulo-vesicular count for the rating of allergic patch test reactions. A simple technique based on polysulfide rubber replica
Authors: Peters K , Serup J.
Published: August 2023

Silicone rubber replica of patch test reactions were obtained from 12 patients with allergic contact dermatitis. 85 positive or doubtful reactions to allergens included in a standard battery were studied. The number of papulo-vesicles and sweat pores as seen in the replica were counted under a stereomicroscope. The papulo-vesicular count increased significantly in relation to clinical reading of the reactions of increasing strength. The number of sweat pores of positive reactions was decreased. This was probably due to cutaneous oedema with compression of sweat gland ducts. Papulo-vesicles are also consequences of the inflammatory oedema. The replica method was concluded to be a useful tool for the grading of allergic patch test reactions. It has the virtues of reproducibility, simplicity and low cost, and it can be evaluated under standardized laboratory conditions. Replica may also be the basis for more sophisticated methods of quantitation such as computer-aided image analysis.
PUVA therapy for photosensitive psoriasis
Authors: Ros AM , Wennersten G.
Published: August 2023

The purpose of this study was to assess the prophylactic effect of oral photochemotherapy with psoralens and UVA (PUVA) on patients with light-sensitive psoriasis. Of fifteen patients with photosensitive psoriasis, ten with a history of polymorphous light eruption (PMLE) slowly developing into psoriasis were treated with trimethylpsoralen (TMP) and UVA. Five patients with no preceding PMLE reaction were similarly treated; two with 8-methoxypsoralen (8-MOP), two with TMP and one in whom 8-MOP was later changed to TMP. Good to excellent results were obtained in 9/10 of the first category and in 3/5 of the second, giving an overall efficacy of 80%. Preexisting psoriatic lesions did not, however, heal during TMP therapy but did so when treated with 8-MOP. The results confirm, for light-sensitive psoriatics, the efficacy of PUVA in photosensitive disorders.
The majority of epidermal Merkel cells are non-proliferative: a quantitative immunofluorescence analysis
Authors: Vaigot P , Pisani A  , Darmon YM , Ortonne JP
Published: August 2023

Although epidermal Merkel cells (MC) are able to form synapses and synthetize neuromediators, they can be considered as being of epithelial nature because of the presence of cytokeratins in their cytoskeleton and desmosomes on their membranes. Since epidermis is an epithelium undergoing permanent renewal, it was important to determine whether MC were able to renew, as neighbouring keratinocytes do. This was investigated by studying whether S phase nuclei could be found in cells bearing a specific MC marker. The technique consisted of injecting rabbits with bromodeoxyuridine (BrdUrd) and performing double immunofluorescence on skin sections with the antikeratin number 8 monoclonal antibody (MAb) TROMA-I and anti-BrdUrd MAb. The results show that, in contrast to the neighbouring epidermal cells, the great majority of MC were found to be devoid of BrdUrd labelling, indicating that most of these cells are unable to divide, or divide very rarely.
Growth kinetics of fibroblasts derived from normal skin and hypertrophic scar
Authors: Oku T , Takigawa M  , Fukamizu H , Inoue K  , Yamada M
Published: August 2023

In vitro growth kinetics of fibroblasts derived from normal skin and hypertrophic scar were performed using continuous 3H-thymidine labeling method. In fibroblasts derived from normal skin, aging of the donor affects cell growth mainly by growth fraction (GF), but not labeling index (LI) and DNA synthetic time (Ts). When hypertrophic scar-derived fibroblasts are compared with normal fibroblasts, they showed a shorter Ts and lower LI and GF. This result suggests that in hypertrophic scar a small number of fibroblasts proliferate more actively, but most fibroblasts are non-growing cells.
Amiodarone photoreactions
Authors: Roupe G , Larkö O  , Olsson SB
Published: August 2023

Four patients with photoreactions after Amiodarone therapy are described. The action spectrum for photosensitivity was found in the UVA region. Pigmentation seems to be due to wavelengths below 360 nm.
Expression of blood group antigens by cultured human epidermal cells used as allografts
Authors: Mauduit G , Ohrt C  , Faure M , Kanitakis J  , Demidem A , Thivolet J
Published: August 2023

The expression of blood-group antigens was studied on human epidermal cultures used as allografts in 13 non-immunosuppressed patients treated for leg ulcers. The study was carried out using monoclonal antibodies to A and B antigens by an indirect immunofluorescence technique. Blood-group antigens are weakly expressed on the suprabasal layers of the cultured epidermal sheets. After grafting, the donor´s blood-group antigens were detected on a few cells of the suprabasal layers. Furthermore, scattered keratinocytes as well as acrosyringia were found to express the recipient´s blood-group antigens.
The Intra Gastric Effects of Grape Juice on Histological Structure of Liver Tissue in Castrated Treated Mice
Authors: MH Homady
Published: August 2023

The effect of ingestion of freshly prepared ethanoic extract of grape juice was investigated on the histology of liver tissue on both castrated and castrated treated with 10 µl/g of grape juice. The histological sections of liver tissue from castrated group showed ballooning degeneration, macro and micro vesicular steatosis, lobular inflammation, hydropic degeneration, cellular inflammatory of lymphocytes and acidophil bodies (Councilman Body) as compared with the control group. The orally administration of 10µl/g grape juice for 6 weeks to castrated subjects was able to restore the histological structure of liver tissue to normal structure as compared with the control group. These results suggest that the fresh extract of grape juice can exert hepatoprotective effects of castration.
Fungal Orbital Cellulitis by Candida Albicans Following Snake Bite -A Rare Case
Authors: P Seth
Published: August 2023

Fungal orbital cellulitis is extremely rare in immune-competent individuals. An ocular manifestation of snake bite is rare and orbital cellulitis following snake bite is one of the rarest entities. A 10 year old boy presented with periorbital edema with lid necrosis following snake bite on upper lid of the right eye. Patient was treated with intravenous empirical antibiotic along with anti-snake venom. The following day, the patient developed proptosis of the right eye. CT scan suggested orbital cellulitis. Microbiological examination confirmed Candida species. Patient was started on intravenous and topical antifungal agent with resultant decrease of proptosis. But, despite ocular improvement, the patient succumbed due to respiratory failure. The present case highlights fungal orbital cellulitis in immune-competent patient as one of the rarest manifestation of snake bite. Clinical suspicion and diagnosis by imaging and microbiological examination and immediate treatment are necessary while treating such patients.
Epidemiological and Clinical Characteristics of Patients Operated for Strabismus at the Yaounde Central Hospital
Authors: VA Dohvoma
Published: August 2023

Purpose: to describe the epidemiological and clinical characteristics of patients operated for strabismus. Methods: records of patients operated for strabismus between 2014 and 2022 at the Yaounde Central Hospital were included in this cross-sectional study. Data collected included: age at onset, age at the time of surgery, sex, type of strabismus, preoperative angle of deviation at distance, number of eyes and muscles operated. Significance level was set at p <0.05. Results: 84 patients were included. There were 57 (67.9%) exotropias and 27 (32.1%) esotropias. Females were predominant, with no significant difference between exotropias and esotropias (70.4% in esotropias and 70.2% in exotropias). Early-onset strabismus was present in 88.9% of esotropias and in 57.9% of exotropias (p=0.0055). The mean age at the time of surgery was respectively 8.6 ± 8.6 years and 18.8±13.9 years for esotropias and exotropias. (p=0.00001). The mean pre-operative angle was 41.1 ± 9.5 prism diopters (PD) in esotropias and 40.2 ± 12.6 PD in exotropias. Surgery was done in both eyes in 82.1% of cases and at least on 2 muscles in 90.5% of cases. Conclusion: surgery for esotropia is carried out in late childhood and that for exotropia in late adolescence. Efforts geared towards sensitizing the public in view of early management of strabismus need to be made.
Corneal Hysteresis in Adult Indian Population
Authors: RM Srivastava
Published: August 2023

Purpose: To evaluate corneal hysteresis (CH) and to study its inter-ocular variability along with its association with gender and age using Ocular Response Analyzer (ORA) among healthy adult Indian population. Methods: This prospective, cross-sectional, observational study was conducted at a tertiary eye care centre in a medical university in India between July and December 2020. 300 healthy participants in age group between 18 to 60 years were recruited from amongst the residents, staff and patients coming for routine examination in Ophthalmology department. Participants with history of systemic/ocular disease, ocular surgery, pregnancy or spherical equivalent refraction >±1D were excluded from study. CH and corneal compensated intra-ocular pressure (IOP-cc) was assessed using ORA. Statistical analysis was done to calculate mean CH in study population. Inter-ocular and gender-wise variability in mean CH was analysed using independent-t test. Pearson correlation coefficient was calculated to study correlation of CH between eyes and with age, gender, IOP-cc and central corneal thickness (CCT). Results: 162 males and 134 females were recruited. The mean age was 37.5±11 years and mean CH in overall study population, males and females were 10.57±1.12, 10.25±0.90, 10.96±1.22 mm Hg. No significant difference in CH, IOP-cc and CCT was observed between eyes. A strong positive correlation was observed in CH between eyes (r=0.75, p<0.001). Conclusions: Mean CH among healthy Indian adult is 10.57±1.12 mm Hg. CH values are higher among females compared to males. CH values between the two eyes in normal individuals are coherent and positively correlated.
Construção e Validação de Instrumentos de Pesquisa de Survey: da Psicologia à Administração
Authors: Vieira Kelmara Mendes , Bressan Aureliano Angel
Published: August 2023

Trata-se de um estudo descritivo e prescritivo, que apresenta os procedimentos teóricos, experimentais e analíticos necessários para a construção ou adaptação de um instrumento de pesquisa. O artigo traça um caminho para a construção de instrumentos, indicando para os pesquisadores quais os principais procedimentos, técnicas e cuidados que precisam ser adotados tanto na fase de construção teórica quanto na etapa de validação empírica. Especifica ainda o objetivo e os critérios a serem utilizados na aplicação da Análise Fatorial Exploratória, da Teoria da Resposta ao Item e da Modelagem de Equações Estruturais, no contexto da validação. Ao final, são apresentadas sugestões aos pesquisadores em administração que precisam construir ou adaptar instrumentos para pesquisas de Survey.