bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychosocial Care Circuit: the systematization of intervention in psychic crisis in mobile pre-hospital care
Authors: Cavalcante Renata de Almeida , Vaz Samita Batista Vieira , Vaz Tiago Silva , Oliveira Gustavo Carvalho de , Rocha Dais Gonçalves
Published: May 2024

An experience report that aims to present the systematization of care for the management of psychic crises developed by the SAMU-DF Mental Health Center. The methodology, based on the steps of the Maguerez’s Arch, allowed both the identification of professionals’ difficulties regarding psychic crises management and the construction of the system called “Psychosocial Care Circuit’’ to guide the assistance of the mobile pre-hospital care. The Circuit has as mnemonic AEIOU, and each letter corresponds to an element evaluated as necessary for the psychic crisis intervention. Therefore, it is possible to affirm that the permanent education in health enables the transformative action of professionals, in addition to transforming the reality in which they are inserted, and that the systematization has accelerated the consolidation of the necessary skills for psychic crises care.
Quem pode atuar com acupuntura no Brasil?
Authors: Mocarzel Rafael , Kornin Alan , Tesser Charles , Ferreira Arthur de Sá
Published: May 2024

Resumo A acupuntura é ofertada no Sistema Único de Saúde (SUS), mas seu exercício é disputado juridicamente. Este estudo analisa os aspectos desse exercício por diferentes profissionais da área da saúde. Realizou-se uma análise de literatura científica e institucional (brasileira e internacional), cuja seleção foi intencionalmente orientada. Os resultados abordam aspectos da disputa sobre o exercício da acupuntura; o ensino da acupuntura e suas normativas; e a operacionalização dos registros do exercício da acupuntura no SUS. A ausência de regras unificadas desse exercício gerou regramento infralegal de instituições governamentais e corporações profissionais no Brasil, admitindo a prática multiprofissional, em conformidade com a Organização Mundial de Saúde .
Valores y Conductas Académicas Deshonestas en Estudiantes Universitarios
Authors: Rodriguez Santos Federico Osorto , Rodriguez Jonatan
Published: May 2024

Objetivo: El estudio analiza los valores (TMV) que se relacionan con las conductas académicas deshonestas en estudiantes universitarios. Método:   Con un enfoque cuantitativo y un diseño no experimental transversal, de alcance relacional-correlacional, se aplicó un instrumento en línea que constaba de dos partes: la primera es el PVQ (Portrait Values ​​​​Questionnaire) de Schwartz (2012) . La segunda parte, fueron diez artículos diseñados para evaluar cinco conductas académicas deshonestas. Se contó con una muestra de 301 estudiantes de universidades públicas y privadas, nacionales (Honduras) e internacionales. Conclusiones: Según los hallazgos, no existe una relación significativa entre los valores personales desde la teoría de Schwartz con las conductas académicas deshonestas. Se ha encontrado evaluación débil positiva entre los Recursos de Poder y Poder-dominación con las cinco conductas académicas deshonestas. El Hedonismo presenta limitación débil positiva con la conducta Duplicar trabajos.   Recomendación: Se sugiere continuar con la búsqueda de correlaciones entre los TMV y otros comportamientos en el contexto hondureño.
Acceso abierto en Argentina: una propuesta para el monitoreo de las publicaciones científicas con OpenAlex
Authors: Unzurrunzaga Carolina , Monti Carolina , Zalba Gastón , Alperin Juan Pablo
Published: May 2024

En este estudio se propone una metodología utilizando OpenAlex (OA) para monitorear el acceso abierto (AA) a las publicaciones científicas para el caso de Argentina, país donde rige el mandato de autoarchivo -Ley 26.899 (2013)-. Se conformó una muestra con 167.240 artículos de investigadores del Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET) que se analizaron con técnicas estadísticas. Se estimó que OA puede representar entre 85-93% de los autores para todas las disciplinas, excepto Ciencias Sociales y Humanidades, donde solo alcanza al 47%. Se calculó que 41% de los artículos publicados entre 1953-2021 incluidos en la fuente están en AA, porcentaje que sube a 46% al considerar exclusivamente el periodo post ley (2014-2021). En ambos periodos es la vía dorada la que representa mayor proporción. Al comparar periodos iguales post y pre ley, se observó que la tendencia en alza de la vía dorada era preexistente a la legislación y la disponibilidad de artículos cerrados en repositorios aumentó un 5% a lo que se estima en base a tendencias existentes. Se concluye que si bien  la vía verde ha tenido una evolución positiva, ha sido la publicación en revistas doradas lo que ha impulsado más rápidamente el acceso a la producción argentina. Asimismo, que la metodología basada en OA, piloteada aquí por primera vez, es viable para monitorear el AA en Argentina ya que arroja porcentajes similares a otros estudios nacionales e internacionales.
Evidencia ecológica de la relación de Croton draco var. draco Schltdl. & Cham. con hongos micorrizógenos
Authors: Olalde Portugal Víctor , Méndez Cortés Heriberto , Navarro Rodríguez Ana María Del Pilar , Ibarra Laclette Enrique , Ramón Farías Feliza
Published: May 2024

Antecedentes: Existen reportes de que los Hongos Micorrizógenos Arbusculares (HMA) incrementan la producción de metabolitos secundarios en plantas medicinales. El género Croton ha sido poco estudiado en este aspecto.  C. draco es una especie etnomedicinal, conocer la relación y naturaleza de los HMA, puede contribuir a obtener plantas en cultivo con mayor calidad y cantidad de metabolitos secundarios.
Preguntas: ¿Las raíces de C. draco pueden ser colonizadas por HMA? ¿Qué especies de HMA se encuentran en la rizósfera de C. draco?  ¿La diversidad de especies de HMA varía dependiendo del ambiente?
Sitios de estudio y periodo de investigación: El estudio se hizo en tres localidades del estado de Veracruz, en el año 2019.
Métodos: Raíces terciarias de árboles adultos se procesaron y observaron al microscopio compuesto buscando esporas, hifas y arbúsculos de HMA.  La diversidad y densidad esporas en la rizosfera de C. draco, se determinó en muestras de suelo, comparando tres sitios de estudio. Los datos se normalizaron y se hicieron pruebas paramétricas. 
Resultados: Se observaron esporas, hifas y arbúsculos en las raíces de C. draco. La abundancia de esporas y diversidad de HMA fue diferente entre los sitios evaluados. Con base en la morfología de las esporas se reconocieron 14 taxones, de los cuales, solo dos están presentes en los tres sitios.
Conclusión: C. draco presentó en sus raíces estructuras propias de los HMA. Basado en los resultados concluimos que las condiciones ambientales influyen en la abundancia de esporas y en la diversidad de especies de HMA.
Legal Issues of Copyright Objects Processing by AI Systems in the Process of Machine Learning
Authors: Afanasyeva Ekaterina , Furman Dmitry
Published: May 2024

The research paper analyses the legal aspects of copyright objects processing by AI systems, including the legality of automated analysis of text and data in digital form — TDM (text and data mining) and machine learning. The research paper examines: the grounds for qualifying such processing as copyright infringement and certain obstacles to the full protection of copyright (including Big Data, being a subject of processing by AI systems). The paper proposes the adoption of certain public law principles of copyright objects processing by artificial intelligent systems, in particular: the principle of limited purpose, according to which the processing of works should be carried out exclusively for the purposes established by the operator of the artificial intellectual system; the principle of limited storage, which involves storing personal data (in a form accessible to identify the subjects of this data) no longer than required in-order to achieve the stated processing purposes; the principle of transparent reporting — reporting on the quantity and quality of processed data sets, accessible to any person, regardless of interest.
An assessment of federal alcohol policies in Canada and priority recommendations: Results from the 3rd Canadian Alcohol Policy Evaluation Project
Authors: Farkouh Elizabeth K. , Vallance Kate , Wettlaufer Ashley , Giesbrecht Norman , Asbridge Mark , Farrell-Low Amanda M. , Gagnon Marilou , Price Tina R. , Priore Isabella , Shelley Jacob , Sherk Adam , Shield Kevin D. , Solomon Robert , Stockwell Tim R. , Thompson Kara , Vishnevsky Nicole , Naimi Timothy S.
Published: May 2024

Objective

To systematically assess the Canadian federal government’s current alcohol policies in relation to public health best practices.

Methods

The 2022 Canadian Alcohol Policy Evaluation (CAPE) Project assessed federal alcohol policies across 10 domains. Policy domains were weighted according to evidence for their relative impact, including effectiveness and scope. A detailed scoring rubric of best practices was developed and externally reviewed by international experts. Policy data were collected between June and December 2022, using official legislation, government websites, and data sources identified from previous iterations of CAPE as sources. Contacts within relevant government departments provided any additional data sources, reviewed the accuracy and completeness of the data, and provided amendments as needed. Data were scored independently by members of the research team. Final policy scores were tabulated and presented as a weighted overall average score and as unweighted domain-specific scores.

Results

Compared to public health best practices, the federal government of Canada scored 37% overall. The three most impactful domains—(1) pricing and taxation, (2) marketing and advertising controls, and (3) impaired driving countermeasures—received some of the lowest scores (39%, 10%, and 40%, respectively). Domain-specific scores varied considerably from 0% for minimum legal age policies to 100% for controls on physical availability of alcohol.

Conclusion

Many evidence-informed alcohol policies have not been adopted, or been adopted only partially, by the Canadian federal government. Urgent adoption of the recommended policies is needed to prevent and reduce the enormous health, social, and economic costs of alcohol use in Canada.
Examining the Effect of Parental Support and Education Provided to Parents
Authors: Özdemir Ahmet Şükrü , İnci Ahmet
Published: May 2024

The study aims to investigate parental involvement in children's mathematics education, with a particular focus on the subject of circles, in the absence of tailored support programs for parents in this area. In this study, the action research method was used. The study sample consisted of voluntary participants among the parents of 6th-grade students. The data collection tools of the study consisted of achievement tests administered to students and their parents, semi-structured interviews with students and parents after the program, and observations of the participants. We found that parents could learn the subjects depending on their level of education, they could be helpful to their children through their existing knowledge, they understood their children better and their beliefs that they could help their children increased. Likewise, children's belief that their parents could help them strengthened, and their academic success in the subject of circles also increased. Consequently, children experience greater happiness in student-centered lessons and display increased proficiency. Moreover, when faced with parts of the subject that they did not understand, they could quickly seek assistance from their parents. Furthermore, the children and parents expressed satisfaction with this study and a desire to continue training.
Teatre complet I (1865-1873)
Authors: i Arderiu, Rossend Arús
Published: May 2024

Aquest primer volum compta amb un llarg estudi introductori –més de seixanta pàgines– de Magí Sunyer Molné, professor titular del Departament de Filologia Catalana de la Universitat Rovira i Virgili en què estudia el conjunt representatiu del teatre menys conegut del Vuit-cents català, la de les societats d'aficionats i la que divertia el públic menestral i obrer. S'han de subratllar la dimensió del teatre polític de Rossend Arús i, sobretot, la importància superior dels seus drames realistes contemporanis i en prosa, en l'escriptura dels quals va ser pioner.
Teatre complet III (1878-1882)
Authors: i Arderiu, Rossend Arús
Published: May 2024

L'edició del teatre complet de Rossend Arús i Arderiu (1845-1891), dramaturg popular, republicà, catalanista, lliurepensador i maçó, posa a l'abast del públic i dels professionals del teatre el total de més de cinquanta peces dramàtiques d’aquest dramaturg, que constitueix la col·lecció més extensa de teatre vuitcentista a l'abast del lector actual.
Clinical and pathogenetic assessment of cyclosporine efficacy in the complex therapy of non-segmental vitiligo patients
Authors: Nikulina Alena S. , Lomonosov Konstantin M.
Published: May 2024

BACKGROUND: Vitiligo is a chronic disease of unknown etiology, characterized by the appearance of depigmented spots on various areas of the skin, rarely on mucous membranes, and discolored hair due to destruction and reduction of melanocytes. While not life-threatening, vitiligo significantly impacts the psychoemotional aspect. Studies assessing the quality of life of vitiligo patients reveal the presence of depression in these individuals. In addition to depression, a high susceptibility to anxiety, stigmatization, sleep disturbances, adaptation, and problems in personal relationships have been identified. The prevalence of depression and anxiety among vitiligo patients is comparable to other dermatological conditions such as atopic dermatitis, acne, psoriasis, and urticaria. This underscores the need to seek new means and methods for treating this condition.
AIM: Clinical assessment of the effectiveness of using cyclosporine in combination with UVB 311 nm and monotherapy with UVB 311 nm for vitiligo.
MATERIALS AND METHODS: The study involved 40 patients with progressive vitiligo. All patients were randomly divided into two groups. Group 1 (20 individuals) underwent a course of cyclosporine therapy in combination with UVB therapy, while Group 2 (20 individuals) received monotherapy with UVB 311 nm. The duration of the treatment was 6 months. The extent of the affected area relative to the body surface area was evaluated using the VES index (Vitiligo extent score) on a vitiligo calculator. The impact of the disease on the quality of life was assessed using the VitiQoL scale (vitiligo-specific quality-of-life instrument).
RESULTS: All patients included in the study completed the full course of treatment. Group 1 (20 individuals) underwent a course of cyclosporine therapy in combination with UVB therapy, while Group 2 (20 individuals) received monotherapy with UVB 311 nm. Patients in the combined therapy group experienced earlier stabilization of the skin process compared to those receiving monotherapy with UVB 311 nm. Additionally, Group 1 demonstrated more pronounced repigmentation of vitiligo lesions and significant improvement in quality of life compared to Group 2.
CONCLUSION: Cyclosporine in combination with narrowband phototherapy at 311 nm demonstrated good clinical efficacy and significant improvement in quality of life for non-segmental vitiligo patients. Cyclosporine is well-tolerated, has a low spectrum of side effects, and can be used long-term for patients with active vitiligo.
An Integrated, Scalable Platform for rAAV Vector Development Designed for Translational Success
Authors:   , Liu Xueyuan , Davidson Beverly , Han Lin
Published: May 2024

Recombinant adeno-associated virus (rAAV) is a leading viral vector modality for gene therapy, with seven approved treatments and hundreds of ongoing clinical trials. rAAV manufacturing, while sufficient to support preclinical studies and clinical trials, is challenged at the scale-up due to the translational gap between vector development and manufacturing. Vector development is often limited to the early stage, small scales, using basic purification processes and analytical tools. It generally focuses on expression, target specificity, and immunogenicity, neglecting the crucial aspects of vector manufacturability (productivity and purity), which are essential for the clinical success of novel therapeutic vectors. I hypothesized that early identification of vector manufacturability is critical and necessary to assist with the translation of novel vectors. To address this, I proposed creating an integrated, scalable, high throughput rAAV screening and optimization platform to overcome vector development and manufacturing challenges at the discovery and pre-clinical stages. This research proceeded in three stages: (1) Develop a microscale rAAV production method for high-throughput productivity screening, enabling simultaneous testing of multiple constructs and conditions at a reduced cost and time without needing special equipment and expertise. It also provides a viable option to optimize vector design, modulate the effects of packaging plasmids, and improve production efficiency with a design of experiments (DOE) approach. The platform is scalable, reflecting productivity propensity at scale. (2) Integrate a novel UV-VIS/DLS/SLS analytic platform and additional methods like CsCl density banding, capillary electrophoresis, Nanopore sequencing, and multiplex ddPCR to screen vector purity. The platform, capable of quantifying and characterizing rAAV vectors in high throughput, eliminates the need for reference standards, large amounts of purified vectors, and intensive training, and is suitable for vector development at the early discovery stage. The combinatorial analytic platform identifies product-related impurities and optimizes vector purity early on. (3) Demonstrate the platform utility by developing a novel rAAV human factor VIII vector for Hemophilia A, ensuring optimized manufacturability for clinical success. This integrated, scalable screening platform will bridge the gap between discovery and clinical manufacturing, improving vector manufacturability throughout therapeutic development and moving novel therapies closer and faster to patients.
AUDITORIAS OPERACIONAIS AMBIENTAIS NOS TRIBUNAIS DE CONTAS: NOVAS PERSPECTIVAS
Authors: Albuquerque Cristhian Carla Bueno de , Catapan Anderson , Oliveira Antonio Gonçalves de
Published: May 2024

O Tribunal de Contas possui competência e capacidade técnica-operacional de controlar e fiscalizar o patrimônio ambiental, por meio de recomendações expedidas aos responsáveis pela gestão do meio ambiente, visando assegurar a preservação deste bem de uso comum do povo e essencial a qualidade de vida da coletividade, garantindo o desenvolvimento sustentável das presentes e futuras gerações. Objetivando analisar a importância da auditoria operacional ambiental e suas contribuições para o desenvolvimento sustentável dos órgãos/entes auditados no Estado do Paraná foi realizada uma pesquisa exploratória por meio de investigação bibliográfica, documental e observação teórico-empírica, apoiando-se em análise descritiva de dados, sobre os procedimentos adotados pelo citado Tribunal. Constatou-se que, embora haja iniciativas importantes para fins de fortalecimento das auditorias operacionais ambientais a atuação do tribunal de contas ainda é incipiente nesta temática, sendo que desde 2009 até o presente ano, menos de 25% dos Municípios paranaenses foram fiscalizados. Depreende-se que são necessárias medidas institucionais visando ao fomento e o aperfeiçoamento dos procedimentos na Corte de Contas Paranaense, a fim de assegurar maior transparência dos relatórios de auditorias, bem como, maior diálogo com o ente auditado e com o Poder Legislativo.
ASPECTOS HISTÓRICOS E JURÍDICOS DAS EMANCIPAÇÕES JUDICIAIS NA COMARCA DE CANOINHAS/SC (1949-2020)
Authors: Tomporoski Alexandre Assis , Borguezan Danielly , De Morais Renata Franco Leite Ciccarino , Dos Santos Gilson
Published: May 2024

Esta pesquisa foi proposta com o intuito de analisar os pedidos de emancipação ajuizados na comarca de Canoinhas/SC entre os Códigos Civis de 1916 e 2002. A área jurídica infelizmente carece de pesquisas dessa natureza, desse modo, vislumbrando associar informações qualiquantitativas da região e dados do poder judiciário local no período ora delimitado, foi possível melhor compreender a dinâmica social e jurídica no que tange a perspectiva da autonomia do indivíduo, advinda na forma da emancipação na comarca de Canoinhas. Outrossim, a temática envolve o estudo sob a égide de dois códigos (CC1916 e CC2002) e, portanto, a análise comparativa dos processos ajuizados no período sob a receptividade da lei vigente.
LABOR AND HUMAN CONDITIONS: BRAZILIAN PANORAMA AND RURAL SPACES
Authors: Pietrafesa José Paulo , Pietrafesa Pedro Araújo
Published: May 2024

The objective of the article is to analyze the working conditions in the Brazilian rural space and whether these conditions are similar or not to slave work. The country's agrarian structure is directly related to the persistence of overexploitation of the labor of rural workers. To develop this study and understand the contradictions existing in rural labor relations in Brazil in the 21st century, the article used the socio-historical method, comprehending the contradiction of national agrarian issues as one of the roots of this phenomenon. Through the database of the Dom Tomás Balduíno Documentation Center it was found that between 2015 and 2019 there was a decrease in the number of occurrences of work analogous to slavery. However, this decrease may be related to the precariousness of the labor inspection system, the criminalization of social movements, the propaganda on social media against the defense of human rights and the speech that became hegemonic, since 2016, regarding the freedom for defense of property. The conflicts generated in rural spaces with the expansion of agrarian capital are confronted with the immediate needs of peasants and rural workers who create conditions to build new knowledge and new potentials for social organization.
TECNOLOGIA SOCIAL E ECONOMIA SOLIDÁRIA EM BLUMENAU: DIFICULDADES E PERSPECTIVAS
Authors: Garcia Santos Nelson Afonso
Published: May 2024

A partir de pesquisa realizada em Blumenau/SC, buscamos identificar possíveis aproximações entre Economia Solidária, Tecnologia Social e Desenvolvimento Local. Para tanto, dois campos de investigação foram abertos: um teórico, onde se estudou sobre as definições e a historicidade das três variáveis: Economia Solidária, Tecnologia Social Desenvolvimento Local e suas possíveis convergências. O outro campo foi empírico, com a aplicação de questionários com participantes de empreendimentos solidários cadastrados ou não na Incubadora Tecnológica de Cooperativas Populares (ITCP/FURB) e com comerciantes da Feira Livre Municipal de Blumenau/PROEB. Os resultados mostram que na teoria existem várias aproximações entre Economia Solidária, Tecnologia Social e Desenvolvimento Local. Porém, na realidade de Blumenau, praticamente, não existe. Em apenas um empreendimento de economia solidária, a ENLOUCRESCER, foi possível identificar a utilização de tecnologia social em sua prática efetiva. Outro resultado obtido, refere-se a pouca ação da universidade na disseminação do conhecimento sobre a Tecnologia Social e, finalmente, podemos afirmar que não existe em Blumenau ações que visam realizar o Desenvolvimento Local.
DESAFIOS DA REGULARIZAÇÃO FUNDIÁRIA URBANA NA REGIÃO CHICO MENDES EM FLORIANÓPOLIS/SC
Authors: Escarrone Elsie Gatiboni , Canella Francisco
Published: May 2024

A vertiginosa e desordenada urbanização do Brasil trouxe desafios ao planejamento urbano e aos processos legais e administrativos pertinentes, resultando em ocupações irregulares e exclusão social. Florianópolis, capital do estado de Santa Catarina, e polo de atração de migrantes, tem um índice estimado de 51% de construções irregulares. O objeto deste estudo é a avaliação do atual estágio do procedimento de Regularização Fundiária do Conjunto Habitacional da Região Chico Mendes, no município de Florianópolis. O projeto de urbanização, iniciado em 1990, com o projeto Habitar Brasil, seguido nos anos 2000, com o projeto Habitar Brasil BID, até hoje não teve a regularização jurídica concluída. A metodologia adotada, de caráter exploratório, caracteriza-se como uma pesquisa empírica, com a análise do fenômeno através de uma análise documental dos aspectos administrativos, legais e sociais. O resultado indica que o projeto de regularização fundiária, já protocolado no Registro de Imóveis, necessita correções em várias fases. Cumpridas as exigências para o registro, há a possibilidade de titulação imediata de 275 famílias, de um total de 1.041.
Fala Feito Homem, Rapaz!
Authors: Dos Santos Diego Mateus , De Miranda José da Cruz Bispo
Published: May 2024

O artigo presente é um empreendimento que tem por intenção identificar, por referências empírica e bibliográfica, as possibilidades de diversificação nas leituras e práticas das masculinidades negras no Brasil contemporâneo diante de imposições sexistas e racistas de performances de gênero na ordem social lida, a partir do método interseccional, cruzando marcadores de classe, raça e gênero para uma concepção ampla sobre o que significa ser homem negro no tempo-espaço em questão.  A partir de conceitos como afrodiáspora e atlântico negro em Gilroy (2001), ponto de vista privilegiado, referenciados em Conrado e Ribeiro (2017), autoetnografia, com bases em Fortin (2017) e Miranda (2022), avenidas identitárias e encruzilhada analítica, partindo de Akotirene (2019), se estabelece um diálogo entre teoria e experiência a fim de uma maior elucidação da problemática in loco.
Quechers Extraction Followed by HPLC Estimation of Steroidal Glycoalkaloids viz, α-Chaconine and α-Solanine in Different Solanaceae Family Vegetable Varieties
Authors: Nagamalla Lavanya
Published: May 2024

Glycoalkaloids are the alkaloid derived chemical constituents naturally produced in various plants species especially Solanaceae family. These chemical constituents protect the plant against predators as well as pathogens. The consumption of high dose of glycoalkaloids was toxic to humans. This study was purposeful to evaluate steroidal glycoalkaloids viz., α-chaconine and α-solanine quantity in different Solanaceae family vegetable varieties. The QuEChERS (Quick, Easy, Cheap, Effective, Rugged, Safe) extraction using acetonitrile as extracting solvent was used for extracting steroidal glycoalkaloids in vegetable samples. In the optimized conditions, the standard chromatogram shows clear resolution of α-chaconine and α-solanine. The analytes were identified at 3.15 min for α-chaconine and 4.88 min for α-solanine. The optimized HPLC (High pressure liquid chromatography) method was validated. The method optimized using acetonitrile and 1.0 mM ammonium acetate buffer at pH 4.2 in 65:45 (v/v) as mobile phase at 0.6 mL/min, μBondapak C18 (10 μm, 4.6x250 mm) column as stationary phase and UV detection is selected at 218 nm. Findings suggest that this method was simple and convenient for the estimation of glycoalkaloids in vegetables. The glycoalkaloids was achieved under the acceptable levels of less than 200 mg/kg as prescribed by USFDA and German Federal Institute for Risk Assessment.
Diosgenin Mitigates Aluminum Chloride Mediated Developmental Toxicity in Drosophila melanogaster
Authors: Chavan Pratiksha , Danane Trupti , Sharbidre Archana , Pawar Sharad , Jadhav Apurva , Jagtap Suresh
Published: May 2024

Aluminum (Al) is a dangerous environmental neurotoxin that can cause tissue inflammation and oxidative stress. Diosgenin (DG) is a chemical that possesses therapeutic potential and is a powerful neuroprotective and antioxidant agent. Due to their unique anatomy, physiology, and diet, newborns are at a higher risk of harm from the developmental toxin Al. Researchers widely used Drosophila melanogaster as a popular model to study the toxicity of Al in recent years. The study investigates potential protective effects of dietary DG on D. melanogaster, a model of Al-toxicity. The larvae were raised on a diet containing 40 mM/kg Aluminium Chloride (AlCl3) and 15 mM/kg DG. AlCl3 caused oxidative stress and neurobehavioural abnormalities. However, dietary DG improved nociception and crawling deficits by restoring acetylcholinesterase levels and reducing oxidative stress. The study found that higher doses of DG reduced the negative effects of AlCl3 exposure, suggesting DG’s antioxidant potential could treat diseases caused by free radicals. The study reveals that Al-rich diets cause oxidative stress in D. melanogaster, affecting development, metabolism, and neurobehavioral function. DG, as an antioxidant, can protect against negative effects, but its benefits decrease with higher concentrations, the ideal dosage being 15 mM/kg.
Detection of Ethanol and Methanol in Hand Sanitizers used in Public Places in Delhi during the COVID-19 Pandemic
Authors: Afaria Neha , Kanojia Rohit , Jaiswal A. K. , Gupta Sudhir K. , Millo T.
Published: May 2024

Since the COVID-19 (coronavirus disease of 2019) pandemic, alcohol-based hand sanitizers are being used widely to prevent the transmission of corona virus. But a major concern is the adulteration of methanol in hand sanitizer. Cases of methanol poisoning increased drastically during the pandemic. This study was carried out to detect ethanol and methanol in hand sanitizers that are being sold and used in public places. The hand sanitizer samples for this study were collected from different public places in Delhi from June-August 2022. A total of 53 samples were collected and the samples were run on Gas Chromatography (GC-HS) for analysis of ethanol and methanol. Methanol was detected in 25 samples. During the COVID-19 pandemic, various cases of methanol poisoning due to consumption or chronic absorption of hand sanitizer have been reported all over the world. Methanol is a toxic alcohol and long-term dermal exposure to this toxic substance can cause severe health effects. During the pandemic, the increased demand of hand sanitizer resulted in uncontrolled manufacturing and sale of hand sanitizers. Data obtained from this study highlight the need to monitor the manufacturing and sale of alcoholbased hand sanitizer by the regulatory bodies and to raise awareness among the public about the toxic effects of methanol.
Systematic Review on Evidence based Therapeutic Potential of Pithecellobium dulce for Health Benefits
Authors: Shukla Mamta , Singh Akanksha , Ghosh Pranabesh , Chatterjee Sirshendu , Singh Pankaj
Published: May 2024

Plants are proved as a beneficial source of natural products having therapeutic uses for long back periods. Epidemiological studies suggested that approximately 33% of drugs in developed countries are derived from a plant. Pithecellobium dulce is one of the plants which have significant diverse medicinal properties. It is a native fruit of tropical America, and it is cultivated throughout India, especially in Andaman. It is rich in flavonoids, tannins, alkaloids, etc. Experimental studies show that P. dulce shows antidiabetic, abortifacient, antitumor, anodyne and larvicidal activities. Furthermore, it shows significant activity against diarrhea, eye inflammation, and anti-venomous as well. It has a specific place in the traditional system of medicine and can be a miraculous part of modern medicine in the future. So, the present review has been designed to explore the pharmaceutical and therapeutic properties of P. ducle based on the available scientific literature.
Protective Effect of Bifidobacterium longum and Streptococcus thermophilus against Simvastatin-Induced Rhabdomyolysis in Hypercholesteraemic Rats
Authors: Raja K. Dilip , Kumari A. Shanta , Rani A. Prameela
Published: May 2024

Simvastatin (SMV), a commonly prescribed drug for lowering lipid levels, is linked to the serious side effect of rhabdomyolysis. This study explores the potential of probiotics, specifically Bifidobacterium longum (BL) and Streptococcus thermophilus (ST), as supplementary treatments to alleviate simvastatin-induced rhabdomyolysis in rats with high cholesterol levels. This study assesses the effects of combining simvastatin with probiotics on parameters such as lipid profiles, renal function, skeletal muscle markers, inflammatory cytokines, and histological characteristics. Rats with elevated cholesterol levels were exposed to SMV treatment alone and in conjunction with probiotics. This study compared the effects of combining simvastatin with BL and ST, focusing on their potential to ameliorate SMV-induced rhabdomyolysis. Combining simvastatin with BL and ST yielded notable outcomes. The supplementation significantly improved lipid profiles by reducing atherogenic lipids and increasing cardioprotective HDL-C levels. Additionally, the probiotics, particularly ST and BL, showed indications of preserving renal function and mitigating the adverse effects of simvastatin on muscle health. Analysis of inflammatory cytokines suggested that probiotics may modulate inflammation. Histological assessments confirmed the protective effects of probiotics by maintaining tissue integrity and normal cell appearance. While BL exhibited a slight advantage over ST, both probiotics demonstrated similar potential as adjunction therapies. This study’s findings highlight the promising role of probiotics, specifically BL and ST, in ameliorating simvastatin-induced rhabdomyolysis. These probiotics show the potential to improve lipid profiles, safeguard renal function, preserve muscle health, modulate inflammation, and maintain tissue integrity. These results provide a hopeful basis for potential therapeutic interventions in individuals experiencing adverse effects associated with SMV treatment.
Peepeth
Authors: Nasufi Adem , Nipič Lara , Džudžar Anastasija , Petrovič Erazem
Published: May 2024

Prispevek obravnava razvoj decentraliziranega družbenega omrežja Peepeth kot alternativo centraliziranim platformam. Prikazane so primerjave med Peepethom in njegovo centralizirano enačico. Predstavljeni so ključni koncepti, ki gradijo splošno uveljavljena družbena omrežja, kot so Twitter, Instagram ali Facebook, in so opisani ter aplicirani na obravnavano platformo - Peepeth. Prispevek ponuja vpogled v možne inovacije na področju decentraliziranih tehnologij, bodoče trende in poglavitne ugotovitve.
Steemit
Authors: Kuzmanovska Iskra
Published: May 2024

Ko govorimo o družbenih omrežjih, so prve asociacije pogosto povezane s platformami, kot so Facebook, Instagram in druge, ki so po svoji infrastrukturi centralizirane, tj. ena osrednja entiteta je lastnik omrežja in ima absoluten nadzor nad njim. V nasprotju s centraliziranim modelom obstaja paradigma decentraliziranih družbenih omrežij, ki temeljijo na distribuirani infrastrukturi. Steemit, kot predstavnik decentraliziranih družbenih omrežij, prinaša novo dinamiko v to paradigmo. Tehnologija veriženje blokov, ki jo uporablja, uporabnikom omogoča večjo zasebnost, zmanjšuje tveganje zlorabe podatkov in odpravlja pristranskost algoritmov, ki so pogosti problemi v centraliziranih modelih. Prav tako nagrajevalni sistem, ki spodbuja uporabnike k ustvarjanju vsebine, predstavlja inovativen koncept, ki bi lahko bil pomemben za prihodnost družbenih omrežij. Ta princip, čeprav na prvi pogled obetaven, prinaša tudi svoje izzive, vključno z obvladovanjem kompleksnosti in vzdrževanjem doslednosti podatkov. Razumevanje prednosti in izzivov decentraliziranih omrežij, skozi prizmo Steemit-a, postavlja temelje za inovacije na področju družbenih medijev. Ta model ne odpira le poti k bolj transparentnim, vključujočim in avtonomnim spletnim skupnostim, temveč tudi postavlja vprašanja o prihodnosti družbenih interakcij na internetu. Integracija decentraliziranih principov lahko prispeva k ustvarjanju bolj trajnostnega in demokratičnega digitalnega prostora.
Gab
Authors: Arsovska Marija , Hrastnik Anemari , Karakaš Sara , Fotak Hana
Published: May 2024

V tem poglavju smo se osredotočili na decentraliziran družben medij Gab. Raziskali smo njegov razvoj kot družben medij ter preučili prehod iz centraliziranega v decentraliziran medij. Predstavili smo ključne koncepte, ki jih platforma uporablja, in analizirali, kako se medij poslužuje teh konceptov. Posvetili smo se metrikam, povezanim z Gabom. Ugotovili smo, da Gab ne zagotavlja obsežnih možnosti za vpogled v analitiko običajnih objav, zato smo se osredotočili predvsem na metrike, ki so namenjene oglaševanju. To nam je pomagalo razumeti, kako te metrike odražajo učinkovitost oglaševalskih kampanj in interakcijo s ciljno publiko. V zaključnem poglavju smo predstavili celostno sliko Gabovega vpliva in izzivov, ki se pojavljajo v decentraliziranem medijskem prostoru. Razpravljali smo o tem, kako se Gab kot platforma sooča z izzivi decentraliziranega okolja.
Ovum Pick Up and in vitro Embryo Production using Sex Sorted Semen in Cows
Authors: Hadimani M.R. , Khillare K.P. , Amle M.B. , Meshram M.D. , Rangnekar M.N. , Mali A.B. , Pitroda M.H. , Sangle B.P. , Jawane V.B.
Published: May 2024

Background: Ovum pick-up, a technique for extracting immature oocytes from antral follicles, with in vitro embryo production, is a way to produce large number of embryos from live donors. Methods: By transvaginal ultrasound-guided ovum pick-up, oocytes were collected from large (9-19 mm), medium (4-8 mm) and small (2-3 mm) ovarian follicles of donor cows (n=8). The recovered oocytes were classified as A, B, C, D and E grades. Oocytes were subjected toin vitro maturation, fertilization (with sex sorted semen) and culture. Cleavage and blastocyst rates were recorded on day 4 and day 7 of culture respectively. Result: Total of 278 follicles were aspirated. The follicles aspirated per cow per OPU session was 12.67±1.86. The oocyte recovery rate was 45.31±7.35. Mean percentage of grade A, B, C, D and E oocytes was 15.69±3.91, 24.97±3.02, 37.53±3.45, 19.44±3.76 and 2.38±2.38 respectively. In vitro maturation rate (IVM%) was 91.71±2.38% and fertilization rate was 90.18±1.52%. Cleavage and blastocyst rates observed was 55.1±5.90 and 24.81±2.95% respectively. The mean percentages of different grades of embryos observed was, code 1: 21.13±2.78, code 2: 14.41±3.25, code 3: 19.56±4.11 and code 4: 44.9±5.90%. Transvaginal ovum pick up can be performed repeatedly without hormonal stimulation. Sex sorted semen can be used for in vitro production of female embryos.
Peran Kualitas Laba Terhadap Nilai Perusahaan: Komisaris Independen dan Kualitas Audit sebagai Variabel Pemoderasi
Authors: Diana Pauline Arum , Pamungkas Imang Dapit
Published: May 2024

The company aspires to generate profits so that the firm value becomes high and shareholders can experience prosperity. In achieving this goal, investors typically rely on experienced individuals, such as a commissioner. Investors also tend to trust companies audited by the KAP. This research aims to test and analyze the quality of profits affecting the firm value as well as the audit quality and independent commissioners as a moderation variable. The application used to analyze the data in this study is Warpls 7.0. The population includes all property and real estate companies from 2020 to 2022, with purposive sampling yielding a sample of 122 data over three years. The implications of this research are achieving profits and increasing firm value, placing trust in commissioners, and recognizing the quality of financial reports audited by KAP. The results indicate that quality profits have a stimulating effect on a firm value. Independent commissioners cannot moderate the relationship between the quality of profits and firm value, while audit quality can moderate this relationship.
Keywords:  Independent Commissioners, Profits, Firm Value, Audit Quality
Petrographic dataset of the Holocene volcanism on the island of El Hierro (Canary Islands, Spain)
Authors: Prieto-Torrell Claudia , Aulinas Meritxell , Cabrera María del Carmen , Criado Constantino , Fernández-Turiel José-Luis , Pérez-Torrado Francisco-José , Rodríguez-González Alejandro
Published: May 2024

This dataset collects the petrographic description of 64 lava flow and pyroclast samples from the Holocene eruptions investigated on the island of El Hierro (Canary Islands, Spain) in the LAJIAL Project (PGC2018-101027-B-I00). The project was developed at the Univer- sity of Las Palmas de Gran Canaria, the GEO3BCN (CSIC), the University of Barcelona, and the University of La Laguna. The petrographic description of each sample includes a location map of El Hierro Island, a picture of the outcrop, a general view of the thin section, and general information about the sample. The geographic location of samples in the maps on page 2 is linked to the corresponding sample petrographic data, and in turn, clicking the location of the sample on the location map accompanying the petrographic data, the user returns to the general maps on page 2.
Klang River Water Quality Assessment and Its Effects on Human Health Using Chemometric Analysis
Authors: Tengku Ibrahim Tengku Nilam Baizura , Andrison Anak Jesi  , Nur Azalina Suzianti Feisal  , Yuanita Windusari  , Nursalfarina Abdul Samat  , Noor Haziqah Kamaludin  , Norfadillah Derahim  , Mohd Azwan Ahmad  , Tengku Norbaya Tengku Azhar
Published: May 2024

Introduction: River water pollution has been a significant hazard to human health and is associated with severe health risks. This study evaluates water quality and heavy metal levels in the Klang River, analyzing their health risks through chemometric analysis. Methods: Inductively Coupled Plasma-Mass Spectrometry (ICP-MS) was used to analyse the heavy metal contents in river water samples obtained from 9 sampling stations. Chemometric statistical techniques (principal component analysis (PCA) and hierarchical cluster analysis (HCA)) are employed to identify the sources of physicochemical properties and heavy metals. The human health risk was evaluated using statistical analysis, apart from hazard quotient (HQ), hazard index (HI), and carcinogenic risk (CR). Results and Discussion: Results showed that the physicochemical parameters were within acceptable limits. The concentration of heavy metals was found to follow a decreasing order of As > Ni below permissible levels, except at P9 and P8. PCA and HCA showed important connections among parameters, emphasizing that COD, NH3N, and TDS are key factors affecting Klang River water quality. Conclusion: The study assesses pollution risks in the Klang River, offering crucial insights for sustainable estuary management. It highlights significant changes in temperature, pH, TDS, BOD, DO, and NH3N levels, along with specific trends in heavy metal concentrations. The Health Risk Assessment indicates acceptable HQ and Target Cancer Risk values. However, the study's limited sample sites and focused timeframe might hinder understanding long-term patterns and regional differences. Extended data collection and additional information are necessary to improve water quality management and protect public health
Analyzing the Impact of Dissolved Organic Components on River Water Quality and Its Implications for Human Health: A Case Study from Banjar District
Authors: Zubaidah Tien , Hamzani Sulaiman , Arifin Arifin
Published: May 2024

Introduction: Environmental contamination, especially water quality, is a global issue. The association between river water quality and human health is explored in Banjar Regency, rich in natural resources and essential rivers, utilizing dissolved organic components concentration as an indicator. Methods: A mixed-methods study in Banjar District, South Kalimantan, Indonesia, examined the impact of river water quality on human health, using dissolved forganic components as a primary indicator. Water quality assessments, nutrient content measurements, consumption surveys, and water-related disease epidemiology provided data. The statistical studies revealed key correlations and patterns. Results and Discussion: Water quality metrics varied among sampling locations. The dissolved fish feed negatively correlated with dissolved oxygen, while nutrient content weakly correlated with gastrointestinal disorders. High water temperatures increased respiratory illnesses. Drinking water from sources with high dissolved fish feed content caused digestive and respiratory problems. The study confirms previous research linking water quality parameters to health effects. The complex relationship between water quality and health is location-dependent, illustrating how environmental factors, especially water quality, shape illness trends. Conclusion: The study illuminates the complex links between river water quality, human health, and water usage in Banjar District. Dissolved fish feed content affects digestive and respiratory disorders, emphasizing the need of water quality management for regional health. These findings guide Banjar District water resource management and public health measures and help solve worldwide environmental pollution issues.
EFFICIENCY OF IMPLEMENTATION OF THE ENERGY MANAGEMENT SYSTEM AT 'RESEARCH AND PRODUCTION COMPANY 'ZOND' LTD
Authors: Vashchyshak Iryna , Movchan Yu.
Published: May 2024

To ensure the correct approach to energy management and efficient use by enterprises and organizations, an energy management system is being implemented. The article is about effectiveness of the energy management system at the 'ZOND' LLC. An analysis of the use of fuel and energy resources is carried out, taking into account the structure of energy consumption and cost. It is established that in order to ensure rational consumption, it is necessary to apply a comprehensive approach to analyzing and prioritizing the proposed energy efficiency measures. The constructive and operational shortcomings of the heating system are described. The implemented measures for the rational use of gas are presented. Lighting aspects are considered, including the transition to LED lamps and the use of natural light. Significant heat losses by external envelope structures are revealed and the implemented measures for the building insulation with polystyrene insulation boards (EPS) are described. The results of the economic analysis are presented. The effectiveness of the measures taken by the enterprise to ensure backup power supply in the conditions of prolonged power outages is analyzed. The analysis of the enterprise's work during prolonged emergency power outages is carried out. A number of both minor and significant shortcomings of the described measures to provide electricity to the company's consumers have been identified. Particular attention is paid to the selection and use of uninterruptible power supply units to keep critical consumers running. The use of special skylights, also known as solar daylight tubes or light tubes, to reduce the use of artificial lighting is proposed. A conclusion is made about the effectiveness of an integrated approach to managing the energy efficiency of an enterprise in the context of modern challenges and a high level of energy efficiency management at this enterprise is confirmed.
MATHEMATICAL MODEL OF THE FREQUENCY CONVERTER SYSTEM OPERATION IN A SHIP'S AUTONOMOUS POWER SYSTEM
Authors: Maslov Ihor , Kulagin Dmytro
Published: May 2024

The article shows the process of building a model of the frequency converter control system for a ship's autonomous power system. This task was solved to simplify the mathematical description of the frequency converter for the ship's autonomous power system. As a result, a mathematical set of probable combinations of operating states of power switches and the corresponding values of generalised voltage vectors of the autonomous inverter using pulse width modulation were obtained. The modelling carried out on the basis of this data confirmed the correspondence of the obtained values of the phase voltage of the autonomous inverter to real energy processes. It is shown that it is important to further study the technical and methodological factors of increasing energy efficiency and the accuracy of the mathematical description of real links of power systems, which will ensure the process of a more qualitative study of energy processes in them.