bluuebunny/crossref_metadata_2025 huggingface dataset:
Pilot Study of the Ex Vivo Blood Leukocytes’ Proteomic Response to Prednisone Stimulation in Corticosteroid-responsive Asthma
Authors: Nikolic Aleksandra , Mark Kevin J. , Dragicevic Sandra , Babic Tamara , Milosevic Katarina , Nestorovic Branimir , Beskoski Vladimir
Published: February 2023

Background:

Leukocytes are key cellular effectors of inflammation in asthma and understanding their function in this disease is of crucial importance. Blood leukocytes reflect the actions of their counterparts in the lungs and they can be obtained through minimal invasive procedures as part of the peripheral blood.

Objective:

The aim of the study was to identify proteins in blood leukocyte proteomes that respond to ex vivo treatment by prednisone in order to pinpoint candidates for predictive biomarkers in corticosteroid- responsive asthma.

Methods:

The study included five children diagnosed with asthma and five healthy children. After the ex vivo treatment of blood samples with prednisone, lysis of erythrocytes was performed and proteins were extracted from the remaining leukocytes by ultrasonic disintegration. Protein extracts were analyzed by reversed phase nano-liquidchromatography–tandem mass spectrometry (LC–MS/MS).

Results:

The stimulation of asthmatics' leukocytes with prednisone has led to an increase in the levels of FYB (fold change 3.4) and LYZ (fold change 2.2) with a statistical significance of p<0.005. The two proteins with expressions significantly altered upon the prednisone treatment should be further explored as tools to evaluate the patient's response before therapy administration, especially when lung function measurements are not possible, as is the case with young pediatric patients.

Conclusion:

The approach that entails ex vivo response of blood leukocytes to therapeutics can facilitate asthma management and help overcome the need for therapeutic adjustments in a clinical setting.
Molecular Dynamic Simulation and 3d-pharmacophore Modeling of Alpha
Mangostin and Its Derivatives against Estrogen Alpha Receptor
Authors: Setyawati Luthfi Utami , Binti Parlan Fateen Izzah Haziqah , Khairul Ikram Nur Kusaira , Yusuf Muhammad , Muchtaridi Muchtaridi
Published: February 2023

Background:

Human estrogen receptor alpha (ERα), which is known to play a role in mediating
cell proliferation, metastasis, and resistance to apoptosis, is one of the targets of breast cancer therapies.
Alpha mangostin (AM) is an active xanthone compound from Garcinia mangostana L. which has
activity as an ERα inhibitor.

Objectives:

This research aims to predict the pharmacokinetic and toxicity, and to study the molecular
interactions of AM derivatives with the ERα using computer-aided simulation approaches through molecular
docking, molecular dynamic, and pharmacophore screening to develop novel anti-breast cancer
agents.

Methods:

Marvinsketch and Chimera programs were used to design and optimize the structure of AM and
its derivatives. For screening the pharmacokinetic and toxicity profiles, the PreADMET web was used.
The AutoDockTools 1.5.6 and LigandScout 4.4.3 Advanced software were used to conduct the molecular
docking simulation and pharmacophore screening, respectively, while the molecular dynamic simulation
was performed using AMBER 16. The results were visualized by Biovia Discovery Studio.

Results:

Molecular docking using Autodock showed that FAT10 derivate has lower binding free energy
(ΔG) (-12.04 kcal/mol) than AM (-8.45 kcal/mol) when docking to ERα and both performed the same
hydrogen bond with Thr347. These support the results of the MMPBSA calculation on dynamic simulation
which shows FAT10 (-58.4767 kcal/mol) has lower ΔG than AM (-42.7041 kcal/mol) and 4-OHT (-
49.0821 kcal/mol). The pharmacophore screening results also showed that FAT10 fitted the pharmacophore
with a fit score of 47.08.

Conclusion:

From the results, it can be suggested that FAT10 has promising activity as ERα antagonist.
Further in vitro and in vivo experiments should be carried out to support these in silico studies.
Coumarin-pyrazoline Hybrids as Selective Inhibitors of the Tumor-associated
Carbonic Anhydrase IX and XII
Authors: Redij Aditi , Carradori Simone , Petreni Andrea , Supuran Claudiu T. , Toraskar Mrunmayee P.
Published: February 2023

Aim:

Human carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII are validated antitumor/
antimetastatic drug and tumor imaging targets with sulfonamide inhibitors and monoclonal antibodies in clinical
development. Coumarins act as isoform-selective inhibitors of these isoforms over the cytosolic and mitochondrial
ones.

Methods:

We report the synthesis and in vitro CA inhibitory evaluation of a large panel of coumarins incorporating
pyrazole-1-carboxamide moieties. Compounds were fully characterized before the assessment of their inhibitory activity.
A stopped-flow CO2 hydrase assay was performed for the biological test.

Results:

These coumarins did not inhibit the widespread, off-target isoforms CA I and II (KI >50 μM), but they were
sub-micromolar CA IX/XII inhibitors with an interesting selectivity index higher than the reference compound. Selectivity
between α- and β-class of CAs was also promising.

Conclusion:

These compounds may be used as leads for the rational design and development of non-sulfonamide CA
IX/XII effective inhibitors.
Nicotine Abuse and Neurodegeneration: Novel Pharmacogenetic Targets
to Aid Quitting and Reduce the Risk of Dementia
Authors: Almahasneh Fatimah , Gerges Romany H. , Abu-El-Rub Ejlal , Khasawneh Ramada R.
Published: February 2023

Nicotine dependence has deleterious neurological impacts. Previous studies found an association
between cigarette smoking and accelerating age-related thinning of the brain's cortex and subsequent
cognitive decline. Smoking is considered the third most common risk factor for dementia,
which prompted the inclusion of smoking cessation in dementia prevention strategies. Traditional
pharmacologic options for smoking cessation include nicotine transdermal patches, bupropion and
varenicline. However, based on smokers’ genetic makeup, pharmacogenetics can be used to develop
novel therapies to replace these traditional approaches. Genetic variability of cytochrome P450 2A6
has a major impact on smokers’ behavior and their response to quitting therapies. Gene polymorphism
in nicotinic acetylcholine receptor subunits also has a great influence on the ability to quit smoking. In
addition, polymorphism of certain nicotinic acetylcholine receptors was found to affect the risk of dementia
and the impact of tobacco smoking on the development of Alzheimer's disease. Nicotine dependence
involves the activation of pleasure response through the stimulation of dopamine release.
Central dopamine receptors, catechol-o-methyltransferase and the dopamine transporter protein, regulate
synaptic dopamine levels. The genes of these molecules are potential targets for novel smoking
cessation drugs. Pharmacogenetic studies of smoking cessation also investigated other molecules, such
as ANKK1 and dopamine-beta-hydroxylase (DBH). In this perspective article, we aim to highlight the
promising role of pharmacogenetics in the development of effective drugs for smoking cessation,
which can increase the success rate of smoking quitting plans and ultimately reduce the incidence of
neurodegeneration and dementia.
Roles of the Stereochemical Code and the Entropic Index q in the
Protein Folding Process: How to Map Out Folding Intermediate
Conformations
Authors: Dal Molin João Paulo , Ribeiro Silva Victor Henrique , de Rosa Letícia Antonelli , dos Santos Soares Ricardo Oliveira , Silva Pablo Andrei , Caliri Antonio
Published: February 2023

Background:

Here, the inverse protein folding problem is approached from
the viewpoint of the entropic index q. We present a brief overview of the problem. Further,
we provide general information about the three-dimensional structure of proteins
and the universal characteristics of the folding process.

Methods:

We explain how the stereochemical model was conceived. Our main objective
is to change how Monte Carlo (MC) simulations are performed. We replace the Boltzmann
weight with the Tsallis weight in order to achieve better sampling. This change
leads to the q Monte Carlo method (MCq). There are two main ways to employ the index
q: one is to set it as a fixed parameter (MCq*), and the other is to set it as an autonomous
variable associated with the instantaneous molecular radius of gyration, a feature that is
allowed by the Beck-Cohen superstatistics. In addition, we propose a meaningful physical
interpretation for the index q. Furthermore, we explain how to assemble amino acid
sequences for the inverse problem.

Results:

We present several results and discuss the implications associated with the MC
and MCq methods. The latter method is an efficient approach to tracking down folding
intermediate conformations, which can enable us to better find and define folding pathways
for successive configurations of a polymeric chain kept in solution at the same
macroscale temperature, T.

Conclusion:

We have explained how and why protein kinetics becomes significantly
more advantageous when we employ q ≠ 1. However, this is only possible if we set the
correct upper value of qmax.
Пробой тяжелых инертных газов импульсом электромагнитного излучения гиротрона частотой 1 THz
Authors: Веселов А.П. , Сидоров А.В. , Калынов Ю.К. , Водопьянов А.В.
Published: February 2023

In this work gas discharge ignited by gyrotrone radiation with frequency 1THz were carried out. Breakdown curves were calculated both for selfignited and initiated discharges. There was shown that in case of breakdown by the pulse radiation with duration longest then several microseconds electric field threshold is the same as in case of continuous wave breakdown. Also the possibility of using a terahertz gyrotron as a radiation source for discharge in gas targets on installations for extreme ultraviolet photolithography was assessed.
Наблюдение кавитационного шума без субгармоники
Authors: Котухов А.В. , Ефремов Д.В. , Банникова И.А. , Баяндин Ю.В. , Уваров С.В. , Наймарк О.Б. , Жарко Н.А. , Дежкунов Н.В.
Published: February 2023

The evolution of the cavitation noise (CN) spectra in the field of a focusing emitter with an increase in the intensity of ultrasound (US) was studied. Spectra without subharmonics f0/2 were recorded for the first time, where f0 is the frequency of the ultrasound generating cavitation,. Such a spectrum is observed in partially degassed water at a high duty cycle of ultrasonic pulses. The threshold for the appearance of sonoluminescence (SL) coincides with the threshold for the appearance of the frequency f0/2 in the CR spectrum. In a pulsed field at an ultrasonic intensity much higher than the cavitation threshold, the SL intensity increases with an increase in the duty cycle of the pulses, while the intensity of the f0/2 line in the CS spectrum decreases.
Effects of a Social Media–Based Mind-Body Intervention Embedded With Acupressure and Mindfulness for Stress Reduction Among Family Caregivers of Frail Older Adults: Pilot Randomized Controlled Trial (Preprint)
Authors: Sui Yufang , Kor Patrick Pui Kin , Li Mengli , Wang Jingjing
Published: February 2023

BACKGROUND

Family caregivers of frail older adults experience high levels of stress. Mind-body interventions (MBIs) focused on caregiver stress are often limited in teaching approaches, difficult to practice, and costly. A social media–based MBI embedded with mindfulness meditation (MM) and self-administered acupressure (SA) may be effective for family caregivers, offer greater usability, and lead to greater adherence.

OBJECTIVE

The aim of this study was to test the feasibility and preliminary effects of a social media–based MBI embedded with MM and SA on family caregivers of frail older adults and to investigate the preliminary effects of the intervention using a pilot randomized controlled trial.

METHODS

A 2-arm randomized controlled trial design was adopted. Family caregivers of frail older adults (n=64) were randomized into either the intervention group (n=32), receiving 8 weeks of social media–based MM and SA, or the control group (n=32), receiving brief education on caregiving for people with frailty. The primary outcome (caregiver stress) and secondary outcomes (caregiver burden, sleep quality, and mindfulness awareness and attention) were measured using a web-based survey at baseline (T0), immediately after the intervention (T1), and at the 3-month follow-up (T2).

RESULTS

The feasibility of the intervention was established with a high attendance rate (87.5%), high usability score (79), and low attrition rate (1.6%). The generalized estimating equation results showed that participants in the intervention group at T1 and T2 experienced a significant improvement in stress reduction (P=.02 and P=.04, respectively), sleep quality (P=.004 and P=.01, respectively), and mindful awareness and attention (P=.006 and P=.02, respectively) compared with the control group. There were no substantial improvements in caregiver burden at T1 and T2 (P=.59 and P=.47, respectively). A focus group session conducted after the intervention had 5 themes: impact on the family caregivers, difficulty in practicing the intervention, the strength of the program, the limitations of the program, and perception of the intervention.

CONCLUSIONS

The findings support the feasibility and preliminary effects of social media–based MBI embedded with acupressure and MM on reducing stress among family caregivers of frail older people and enhancing sleep quality and mindfulness levels. A future study with a larger and more diverse sample is proposed to evaluate the longer-term effects and generalizability of the intervention.

CLINICALTRIAL

Chinese Clinical Trial Registry ChiCTR2100049507; http://www.chictr.org.cn/showproj.aspx?proj=128031
Developing a Game (Inner Dragon) Within a Leading Smartphone App for Smoking Cessation: Design and Feasibility Evaluation Study (Preprint)
Authors: White Justin S , Salem Marie K , Toussaert Séverine , Westmaas J Lee , Raiff Bethany R , Crane David , Warrender Edward , Lyles Courtney , Abroms Lorien , Thrul Johannes
Published: February 2023

BACKGROUND

Several stand-alone smartphone apps have used serious games to provide an engaging approach to quitting smoking. So far, the uptake of these games has been modest, and the evidence base for their efficacy in promoting smoking cessation is still evolving. The feasibility of integrating a game into a popular smoking cessation app is unclear.

OBJECTIVE

The aim of this paper was to describe the design and iterative development of the Inner Dragon game within Smoke Free, a smartphone app with proven efficacy, and the results of a single-arm feasibility trial as part of a broad program that seeks to assess the effectiveness of the gamified app for smoking cessation.

METHODS

In phase 1, the study team undertook a multistep process to design and develop the game, including web-based focus group discussions with end users (n=15). In phase 2, a single-arm study of Smoke Free users who were trying to quit (n=30) was conducted to assess the feasibility and acceptability of the integrated game and to establish the feasibility of the planned procedures for a randomized pilot trial.

RESULTS

Phase 1 led to the final design of Inner Dragon, informed by principles from psychology and behavioral economics and incorporating several game mechanics designed to increase user engagement and retention. Inner Dragon users maintain an evolving pet dragon that serves as a virtual avatar for the users’ progress in quitting. The phase-2 study established the feasibility of the study methods. The mean number of app sessions completed per user was 13.8 (SD 13.1; median 8; range 1-46), with a mean duration per session of 5.8 (median 1.1; range 0-81.1) minutes. Overall, three-fourths (18/24, 75%) of the participants entered the Inner Dragon game at least once and had a mean of 2.4 (SD 2.4) sessions of game use. The use of Inner Dragon was positively associated with the total number of app sessions (correlation 0.57). The mean satisfaction score of participants who provided ratings (11/24, 46%) was 4.2 (SD 0.6) on a 5-point scale; however, satisfaction ratings for Inner Dragon were only completed by 13% (3/24) of the participants.

CONCLUSIONS

Findings supported further development and evaluation of Inner Dragon as a beneficial feature of Smoke Free. The next step of this study is to conduct a randomized pilot trial to determine whether the gamified version of the app increases user engagement over a standard version of the app.
How Public Relation Exist and Operate in the Organisation?
Authors: Wu Jian
Published: February 2023

With the development of technology and the change of life style, organisations are seeking more effectiveness and efficient way to practice the public relations. How public relation works in the organisations has been studies extensively. This essay will focus on how public relation exist and operate in the organisation from three different aspects which are traditional media, social media and stakeholder engagement which link one-way or two-way Grunig and Hunt’s models. The one-way or two-way Grunig and Hunt’s models will be explained in the essay as well. Moreover, the essay will take M&M’s chocolate, Brisbane City Council and Manila Water Company as three examples to testify how the three approaches working in the public relations in society. Finally, it is recommended that the organisations are better to choose the suitable method basing on the organisations’ strategy and which ethical framework they applied.
Developing Vietnamese Learning Courses for International Learners: Lessons Learned from Teachers’ Perspectives
Authors: Hung Luu Nguyen Quoc
Published: February 2023

Educational institutions have placed increasing importance on internationalizing their curricula over the past few decades as a determining strategy to prepare their learners for employment in the global economy. Internationalization of curriculum, particularly at the level of course development, provides an opportunity for teachers to infuse an international dimension into their courses to increase learners’ interest and motivation, and more importantly, to engage learners in authentic and critical regional and global issues that help them understand and analyze their place in this complex interconnected world. At the Center of Foreign Languages of Can Tho University in Vietnam, the program of teaching Vietnamese is designed to offer Vietnamese language courses to foreigners and overseas Vietnamese. This descriptive study was conducted with a group of 7 teachers at the Center who are teaching Vietnamese to international learners from various nationalities with the aim to understand the teachers’ perceptions of an effective internationalized course and to identify successful strategies to internationalize the courses. The results from the survey and a semi-structured interview revealed that localization and standardization are two significant factors affecting the success of internationalizing Vietnamese learning courses.
AI-Chronic Disease Suggestion System
Authors: Valarmathi.E Valarmathi.E , Gladsingh.R Aswin , Balajee.V Balajee.V , Pratheep.S Pratheep.S
Published: February 2023

The core of artificial intelligence is certification. It demonstrates a productive method for resolving urgent issues, and it denotes how to approach a dataset. For speedier access and seamless client service, we integrate artificial intelligence into our concept. Tensor-flow is used in its development to accelerate activities and automate data collection. Our module is standardised using a standard scaler. Cross-validation is done using the grid-search CV approach. The random-forest algorithm is the algorithm that we defined here. We reduce processing time while increasing usability adaptability. We criticise the strong emphasis on current solutions when it comes to attribution as a process for knowledge development since this focus influences the knowledge structure. Like chronic illness, which takes a lengthy time to diagnose because it is a long-lasting sickness, everywhere on the globe, chronic diseases are dangerous illnesses that are more expensive to detect and force the patient to endure their effects for the rest of their lives. There is a wealth of information about these diseases in the medical field; thus, data mining techniques are used to simplify the healthcare system.
Microstructural adaptations of the subchondral bone are related to the mechanical axis deviation in end stage varus OA knees
Authors: Colyn W , Azari F , Bellemans J , Harry van Lenthe G , Scheys L
Published: February 2023

Recent studies highlighted the crucial contribution of subchondral bone to OA development. Yet, only limited data have been reported on the relation between alteration to cartilage morphology, structural properties of the subchondral bone plate (SBP) and underlying subchondral trabecular bone (STB). Furthermore, the relationship between the morphometry of the cartilage and bone in the tibial plateau and the OA-induced changes in the joint’s mechanical axis remains unexplored. Therefore, a visualisation and quantification of cartilage and subchondral bone microstructure in the medial tibial plateau was performed. End stage knee-OA patients with varus alignment and scheduled for total knee arthroplasty (TKA) underwent preoperative fulllength radiography to measure the hip-knee-ankle angle (HKA) and the mechanical-axis deviation (MAD). 18 tibial plateaux were μ-CT scanned (20.1 μm/voxel). Cartilage thickness, SBP, and STB microarchitecture were quantified in 10 volumes of interest (VOIs) in each medial tibial plateau. Significant differences (p < 0.001) were found for cartilage thickness, SBP, and STB microarchitecture parameters among the VOIs. Closer to the mechanical axis, cartilage thickness was consistently smaller, while SBP thickness and STB bone volume fraction (BV/TV) were higher. Moreover, trabeculae were also more superior-inferiorly oriented, i.e. perpendicular to the transverse plane of the tibial plateau. As cartilage and subchondral bone changes reflect responses to local mechanical loading patterns in the joint, the results suggested that region-specific subchondral bone adaptations were related to the degree of varus deformity. More specifically, subchondral sclerosis appeared to be most pronounced closer to the mechanical axis of the knee.
Phytochemical, GC-MS, FTIR and Amino acid profile of methanol extract of Tetrapleura tetraptera fruit
Authors: Nsofor Winifred Njideka , Nwaoguikpe Reginald Nwazue , Ujowundu Favour Ntite , Keke Collins Obinna , Uba Muhammad Tasi’u , Edom Chibuike Valentine
Published: February 2023

The methanolic fruit extract of Tetrapleura tetraptera was analyzed for the presence of phytocompounds, their bioactivity, the functional groups involved in this activity, and its amino acid profile using standard procedures. Phytochemicals such as tannins, phenols, flavonoids, and alkaloids were identified as being highly present. Gas chromatographic-mass spectrometric (GC-MS) analysis identified 16 bioactive compounds, with 2-thiopheneethanol (58.77%) being the most abundant. Curcumin, with the most diverse pharmacological role, and other bioactive compounds such as cedren-13-ol, 8 (1.56%), N-benzyl stearamide (4.46%), a prominent fatty acid amide hydrolase (FAAH) inhibitor; pthalic acid, butyl undecyl ester (1.49%); and phenol, 2, 6-bis (1,1 dimethyl ethyl) (1.46%), were also present. Fourier transform infrared (FTIR) analysis confirmed the presence of alkanes, esters, benzene rings, aliphatic, sulfonic acid, and methylene chains. Also, the amino acid analysis of the T. tetraptera revealed that the fruit contains 18 amino acids. Leucine (4.20%), phenylalanine (3.37%), and valine (3.25%) were the most abundant essential amino acids identified, with glutamic (7.20%) and aspartic acid (5.61%) having the highest concentrations as non-essential amino acids. This therefore indicates that T. tetraptera fruit could be used as a pharmacological or therapeutic agent as well as a dietary condiment, particularly at this time when there is a demand for novel protein sources.

Keywords: Tetrapleura tetraptera, phytochemicals, GC-MS, FTIR, amino acid, curcumin
Antihyperglycemic Effects of Methanol Extract and Fractions of Oxytenanthera abyssinica Leaf (A. Rich.) Munro (Poaceae) in Alloxan-Induced Diabetic Albino Wistar Rats
Authors: ATCHRIMI KOMI SAGNAN , TOUGOMA ATEHEZI , OMALE SIMEON , BATAWILA KOMLAN , EGESIE GIDEON UMEZURUIKE , ODEH SAMUEL ODU
Published: February 2023

The present study was carried out to investigate the antihyperglycemic effect of Oxytenanthera abyssinica leaf extract and fractions. Diabetes was induced in rats by administering a single dose of 150 mg/kg of alloxan monohydrate. Single doses of 100 and 200 mg/kg of methanol extract (Met-E), n-hexane fraction (nHex-F), ethyl-acetate fraction (EA-F) and methanol fraction (Met-F) were orally administered to diabetic rats. Met-E and Met-F were selected and administered at 400 mg/kg. The plasma glucose level was checked at 0, 1, 2, 4, 8, 12, and 24 h after treatment in acute effect study. Then once daily administration dose effect of 400 mg/kg of Met-E and Met-F was evaluated in chronic study for 28 days. The dose of 200 mg/kg of Met-E and Met-F significantly (p<0.05) decreased the plasma glucose level at 12th hour after treatment while their marked decrease effect at 400 mg/kg was observed at 4th hour after treatment. The repeated administration of Met-E showed a significant (p<0.05) decrease effect in plasma glucose level at the end of 1st, 3rd and 4th weeks while Met-F showed a significant (p<0.05) decrease effect at the end of 2nd, 3rd and 4th weeks. Treatment with Met-E and Met-F reduced pancreatic tissue deterioration compared to diabetic control. The present results showed that methanol extract and fraction of Oxytenanthera abyssinica exerted antihyperglycemic effect both in acute and chronic administration, which might be due to an amelioration of alloxan-induced pancreatic islet’s tissue damages.

Keywords: Alloxan, Oxytenanthera abyssinica, Antihyperglycemic effect, Pancreas, Methanol extract, Methanol fraction.
Contemporary Review on Solubility Enhancement Techniques
Authors: NARMADA ILLA
Published: February 2023

The limited water solubility of pharmacoactive molecules hinders their ability to be used as pharmacological agents, yet the indispensability of a certain solubility parameter precludes any compromises. To overcome this challenge, various methods are employed in order to increase their bioavailability. Pharmaceutical molecules with lower solubility present an elevated risk of failure for drug development and innovation. Their solubility affects important processes such as pharmacokinetics, pharmacodynamics, distribution, protein binding, and absorption. As a result these parameters are greatly impacted by the dissolution rate of a particular molecule. Out of all pharmaceutical dosage forms, more than half are oral. For the drug molecule to reach its target site and be effective therapeutically, solubility and bioavailability must be taken into consideration. Unfortunately, during screening programs conducted by the pharmaceutical industry it became evident that nearly 40% of new chemical entities (NCEs) face various roadblocks when transitioning from formulation to development due to their poor solubility and bioavailability. The pharmaceutical industry is constantly confronted with the difficulty of improving drug bioavailability and solubility in formulations. This article covers a range of technological advancements to boost the solubility of insoluble drugs, such as complexation, emulsions and micelles production, microemulsion generation with cosolvents, polymeric micelle preparation methods, particle size decrease techniques, pharmaceutical salts application, prodrugs usage, solid-state alteration practices, soft gel technology implementation crystal engineering approaches and nanomorphology. Through this review, we will discuss a variety of more complex methods for improving solubility and bioavailability such as crystal engineering, micronization, solid dispersions, nano sizing, and use of cyclodextrins, solid lipid nanoparticles (SLNPs), colloidal drug delivery systems and drug conjugates. We'll also provide references to studies that have been conducted in connection with these topics.

Keywords: Solubility, permeability, bioavailability, nano particles drug delivery systems, microemulsions, low water solubility
Pengaruh kompensasi terhadap kinerja karyawan di kanvaz patisserie by vincent nigita seminyak
Authors: Tirta Samuel Virya , Purnantara I Made Hadi
Published: February 2023

Penelitian ini bertujuan untuk menganalisa bagaimana pengaruh kompensasi terhadap kinerja karyawan di Kanvaz Patisserie by Vincent Nigita Seminyak. Jenis penelitian ini adalah analisis deskriptif kuantitatif. Pengambilan sampel penelitian ini menggunakan non-probability sampling dimana sampel yang diambil merupakan keseluruhan populasi yaitu sebanyak 37 responden yang merupakan karyawan di Kanvaz Patisserie by Vincent Nigita. Data penelitian ini diperoleh dari kuesioner yang termasuk sebagai sumber data primer dan hasil penelitian dari analisis regresi linear sederhana yang diperoleh adalah Y = 25,311 + 0,508 X. Berdasarkan persamaan tersebut, menunjukkan bahwa kompensasi secara berpengaruh positif terhadap kinerja karyawan di Kanvaz Patisserie by Vincent Nigita Seminyak.
 
This research is intended to analyze how is the effect of compenstation on employee performance at Kanvaz Patisserie by Vincent Nigita Seminyak. This research is a quantitative descriptive. The collective of samples using non-probality sampling techniques which means the sample is collected from all of the population that available which amount to 37 respondent who are all the employee that work at Kanvaz Patissserie by Vincent Nigita. Data of this research were collected from questionnaire which is primary data source and the result of this research by using simple linear regression analysis is Y= 25,311 + 0,508 X. Based on that result, it shows that compensation has a positive effect on employee’s performance at Kanvaz Patisserie by Vincent Nigita Seminyak.
The Influence Of Liquidity And Profitability On Stock Prices Of Food And Beverage Companies Listed In Indonesia Stock Exchange
Authors: Loya Ermelinda Suryanti , Rahmawati Christina Heti Tri
Published: February 2023

This study aims to determine if:1) liquidity and profitability simultaneously have a significant influence on stock prices of food and beverage companies listed in Indonesia Stock Exchange (IDX) for the 2015-2019 period, 2) liquidity partially has a significant influence on stock prices of food and beverage companies listed in IDX for the 2015-2019 period, 3) profitability partially has a significant influence on stock prices of food and beverage companies listed in IDX for the 2015-2019 period. The research population is 26 food and beverage companies listed in IDX for the 2015-2019 period. The research sample is 16 companies. The sampling technique used is purposive sampling. Data are obtained from the companies’ annual reports. The data analysis technique in this study is multiple linear regression analysis. The results of this study show that: 1) liquidity and profitability simultaneously have a significant influence on stock prices of food and beverage companies listed in IDX for the 2015-2019 period, 2) liquidity partially has no significant influence on stock prices of food and beverage companies listed in IDX for the 2015-2019 period, 3) partially profitability has a significant influence on stock prices of food and beverage companies listed in IDX for the 2015-2019 period.
Development Of A Systematic, Accountable And Inclusive Mechanism Through Talent Management In Preparing Future Leaders
Authors: Caya Bustanul Arifin , Djamil Masydzulhak , Sutawijaya Ahmad Hidayat , Affini Dinar Nur
Published: February 2023

The Bureaucratic performance is generally characterized by the low quality of public services. Talent management is a mechanism in order to attract, motivate and retain qualified leaders. Therefore, this study aims to analyze the development of talent management in order to prepare future leaders. Talent management is the result of a paradigm shift in human resource management. Experts divide the definition of talent management into two spectrums, namely exclusive and inclusive. Both definitions aim to increase the organization's opportunities in order to increase the achievement of its objectives. The success of implementing talent management in various countries and the private sector has encouraged the Indonesian government to adopt talent management as part of the bureaucratic reform agenda. This study showed that the implementation of talent management requireed 3 values including: 1) A transparent process is one of the keys to the successful implementation of talent management in public institutions; 2) Several methods that can be used are assessment center, 9 talent boxes and development program; and 3) the talent management implementation process requires commitment from all elements of the institution. In addition, the development of talent management is formed in several stages. 1) Establishment of regulations to support the development of talent management; 2) Establishment of an Assessment Center as a center for assessing the competence of prospective leaders; 3) Reorientation of the preparation of position competencies through the Assessment Center; 4) Talent management development; 5) Integration of talent management programs with education and training through the utilization of the talent pool; 6) Establishment of a Corporate University as part of the commitment to the talent development program in the talent pool.
An Analysis Of Communication Celebrity Endorsement On Brand Image
Authors: Dewi Inge Bunga Mira , Anaway Karina Amalia , Poernomo Marlinda Irwanti , Jamalullail Jamalullail , Wandrial Son
Published: February 2023

The main objective of this study is to propose a conceptual model to assess whether persuasive messages can lead to acceptance in the form of information provided by Instagram social media opinion leaders, and, also, the extent to which messages on products and services affect brand image recommended by celebrity endorsement. Communication helps managers to do their jobs and responsibilities. Communication serves as the basis for planning. Celebrity endorsement are used as a common corporate communication strategy to build brand image. Advertisers believe that the use of celebrity endorsement affects advertising effectiveness as well as on purchase intention and repurchase. The study used a quantitative approach using 241 samples from clothing consumers using multiple linear regression processed with SPSS 25. The results of this study found that there was a significant and positive influence of celebrity endorsement on clothing companies brand image. Celebrity endorsement play an important role in improving clothing companies brand image with the endorsement method carried out by celebrity endorsement proven to be able to give a positive impression on the brand image in the eyes of consumers, especially on social media Instagram.
Analysis Location, Word Of Mouth and Security Against the Decision to Purchase Permata Buana Kembangan Housing in West Jakarta
Authors: Samudro Amzad , Hamdan Hamdan , Rahmat Abdul
Published: February 2023

This research is about the decision to buy housing at Permata Buana Kembangan, West Jakarta and this study aims to determine the effect of location, word of mouth, and security on purchasing decisions for Permata Buana housing and respondents who will buy Permata Buana housing. This research is descriptive and quantitative. Primary data and secondary data were obtained. Secondary data was obtained from various sources such as journalists, books, and primary data for other related publications obtained by distributing questionnaires to target respondents. Determination of the number of samples using the purposive sampling technique will be distributed via google form to 83 respondents obtained. The results showed that Location had a significant relationship with purchasing decisions, Word of Mouth was not significant for purchasing decisions, and Security was not significant for purchasing decisions.
The Effect of Transformational Leadership Towards Work Engagement: The Variable Meaning Of Work as a Mediation at the Secretariat Region of East Java Province
Authors: Yulianti Praptini , Permatasari Dita Ayu
Published: February 2023

This study aims to see the effect of transformational leadership on work engagement with the meaning of work as a mediating variable at the Regional Secretariat of East Java Province. The population in this study were all employees with civil servant status in the existing bureaus at the Regional Secretariat of East Java Province, a total of 300 people. Sampling in this study used Slovin’s formula therefore the results obtained were 81 people. The measurement technique uses SEM-PLS ( Structural Equation Modelling-Partial Least Square on the software Smart PLS. The results of this study indicate that transformational leadership has a positive effect but not a significant effect on work engagement and the meaning of work can mediate the relationship between transformational leadership and work engagements. The mediation behavior finding in this meaning of work is full mediation, which means the independent variable is not able to significantly influence the dependent variable without going through the mediator variable, transformational leadership is unable to significantly influence the work engagements. Variable mediating behavior meaning of work strengthen influence transformational leadership to work engagement.
A Multidimensional Model of Planned Behavior Theory and Its Prediction on Entrepreneurial Intention
Authors: Mawardi Mukhammad Kholid , Sujarwoto Sujarwoto , Sahputri Rindi Ardika Melsalasa
Published: February 2023

It is widely believed that entrepreneurial intention is a central concept within entrepreneurial education. Students who have entrepreneurial intentions tend to be self-employed and were not likely to be job seekers. Therefore, in the domain of entrepreneurial research, entrepreneurial intention is a critical issue in studying entrepreneurship.Objectives: The study examines the multidimensional model of theory of planned behavior and its prediction on entrepreneurial intention among university students. The premise of this theory is that individual attitude and behavior are complex processes in which multiple factors determine effectiveness. This study investigates whether this theory will be best described with a multidimensional construct or a single construct and how the relationship path of each dimension.Methodology: The study used a cross-sectional design. Data was distributed to 583 university students in the vocational program at Brawijaya University Indonesia. Data was analyzed using multi-group structural equation modeling in two steps: measurement model test and structural model test. The measurement model was used to test and validated the instrument at the latent variable level while Confirmatory Factor Analysis (CFA) was used to test the model.Finding: The study found entrepreneurial intention was established by a continuum construct: choice intention, commitment to entrepreneurship, and nascent entrepreneurship. Attitude toward entrepreneurship consists of two dimensions, affective and instrumental attitude. Perceived behavioral control comprises of self-efficacy and perceived controllability. Every dimension of entrepreneurial intention has a different relationship with the dimensions of attitude and perceived behavioral control with self-efficacy and affective attitude as the stronger predictor of entrepreneurial intention than instrumental attitude and perceived controllability. The association of choice intention on commitment and the effect of commitment on nascent entrepreneurship is larger among males rather than females.Conclusion: The study answered the necessity to conduct and test an empirical model of the multidimensional construct of planned behavior theory and entrepreneurship intention. By treating the model as multiple models, we proposed a new perspective of the best model that describes entrepreneurial behavior. Using structural equation modeling, this study reveals the different relationship paths of each dimension.
Enterprise Resource Planning Implementation: User Satisfaction on Service Information System Quality
Authors: Dharma Putra I Made Yuko , Nusraningrum Dewi
Published: February 2023

Objectives: This study was conducted to analyze the success of ERP implementation and user satisfaction after using the ERP system at flexible packaging manufacturing companies.Methodology: This study uses a quantitative method with causal analysis using tools from Smart PLS. The population of this study are ERP system users with a sample of 300 respondents using a random sampling technique The population of this study includes all employees of flexible packaging manufacturing companies. The respondents in this study are employees who use ERP systems.Finding: The results found that the greater the quality of the system provided, the better will the user satisfaction Increased user satisfaction can be achieved by producing good quality information, and good service quality of a system will also increase user satisfaction. Satisfied users will increase the benefits received by the company in its business processes.Conclusion: Greater benefits can be received by improving information quality, service quality, and system quality, and. User satisfaction can be used as a mediation of information quality, service quality, and system quality towards the successful implementation of ERP.
Editorial: A cross-disciplinary vision of the corporate governance research
Authors: Kostyuk Alexander
Published: February 2023

The recent issue of the journal has been composed of the papers which are mostly empirical and contribute new ideas to the major issues of corporate governance such as ownership structure, a board of directors, board gender diversity, earnings management, auditing, etc. We have a pleasure to inform you that scholars from many countries of the world are authors of these papers. They represent the USA, Canada, Germany, Italy, Egypt, India, Jordan, etc. This makesthe recent issue of the journal very interesting for the readers
spateGAN: Spatio-Temporal Downscaling of Rainfall Fields using a cGAN Approach
Authors: Glawion Luca , Polz Julius , Kunstmann Harald Günter , Fersch Benjamin , Chwala Christian
Published: February 2023

Climate models face limitations in their ability to accurately represent
highly variable atmospheric phenomena. To resolve fine-scale physical
processes, allowing for local impact assessments, downscaling techniques
are essential. We propose spateGAN, a novel approach for spatio-temporal
downscaling of precipitation data using conditional generative
adversarial networks. Our method is based on a video super-resolution
approach and trained on ten years of country wide radar observations for
Germany. It simultaneously increases the spatial and temporal resolution
of coarsened precipitation observations from 32 km to 2 km and from 1
hour to 10 minutes. Our experiments indicate that the ensembles of
generated temporally consistent rainfall fields are in high agreement
with the observational data. Spatial structures with plausible advection
were accurately generated. Compared to trilinear interpolation and a
classical convolutional neural network, the generative model
reconstructs the resolution-dependent extreme value distribution with
high skill. It showed a high Fractions Skill Score of 0.73 for rainfall
intensities over 15mmh and a low BIAS of 3.55%. A
power spectrum analysis confirmed that the probabilistic downscaling
ability of our model further increased its skill. We observed that
neural network predictions may be interspersed by recurrent structures
not related to rainfall climatology, which should be a known issue for
future studies. We were able to mitigate them by using an appropriate
model architecture and model selection process. Our findings suggest
that spateGAN offers the potential to complement and further advance the
development of climate model downscaling techniques, due to its
performance and computational efficiency.
Spatial spice model of a wireless sensor network node based on a thermoelectric generator
Authors: Marjanovic Milos , Stojkovic Aleksandra , Prijic Aneta , Dankovic Danijel , Prijic Zoran
Published: February 2023

This paper presents a spatial SPICE model of a wireless sensor network node that enables simulation of performances in the steady-state and time-domain. The model includes constructive non-electrical parts of the node and a thermoelectric generator employing the thermoelectric effects. The simulation results are compared with the experiment to validate the model. It enabled the characterization of WSN nodes comprising different thermoelectric generators and heatsinks in terms of energy conversion efficiency.
Event-triggered sliding mode control for constrained networked control systems
Authors: Sarjas Andrej , Gleich Dusan
Published: February 2023

The paper describes a Non-linear Control (ETNC) approach for constrained Networked Feedback Control Systems (NFCS). The real-time controller execution is implemented based on the Event-triggering paradigm. A nonlinear variable structure is used for the controller design. The nonlinear approach is based on the predefined sliding variable defined by the system states with a nonlinear switching function. The system's stability is analyzed regarding the evolution of the sliding variable. The Event-Triggered operation of the nonlinear controller is based on the prescribed triggering rule. The stability boundary of the sliding variable is subject to the preselected triggering condition, whose selection is a tradeoff of system performance, networks constraints and transmission capabilities. The main focus of the Event triggering approach is lowering network resources utilization in the steady-state behavior of the NFCS. The presented approach ensures a non-zero inter-event time of controller execution, which enables scheduling and optimization of the network operation regarding the network constraints and real-time system performance. The efficiency of the presented method is presented with a comparison of the classical time triggering approach. The real measurement supports the results.
Effect of low aluminum additions in the microstructure and mechanical properties of hot forged high-manganese steels
Authors: Morales-Cruz E.U. , Vargas-Ramírez M. , Lobo-Guerrero A. , Cruz-Ramírez A. , Colin-García E. , Sánchez-Alvarado R.G. , Gutiérrez-Pérez V.H. , Martínez-Vázquez J.M.
Published: February 2023

In the present work, the effect of low aluminum additions and the hot forging process on the microstructure and non-metallic inclusions of high manganese steels is analyzed. Four high-manganese steels (HMnS) were prepared by adding low aluminum contents of 1.1 and 1.5 wt. % to four carbon austenitic steels with medium carbon content (0.3 - 0.4 wt% C) and manganese contents of 17 and 22 wt. Samples of the as-cast steels were hot forged to 1100?C to obtain an overall reduction of 70 %. Microstructural evolution was studied using microscopy techniques (OM, and SEM-EDS) and X-ray diffraction measurements for the as-cast and hot forged steels. A typical grain columnar zone formed during solidification of a cast ingot was obtained in the as-cast condition, where the microstructure consisted of nonmetallic inclusions in a fully austenitic matrix. The non-metallic inclusions were identified as Al2O3 and MnS particles. Thermomechanical treatment allows the formation of an austenitic microstructure characterized by twins in steels with high manganese content, while an austenitic-martensitic duplex microstructure was obtained in HMnS, which contained the lowest manganese contents. The highest tensile strength values were obtained for 17Mn-1Al steel, which had the smallest grain size and higher content of non-metallic inclusions. The hardness values were similar to those obtained in the as-cast condition.