bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effects of Quercetin Supplementation on Blood Pressures and Endothelial Function Among Patients with Metabolic Syndrome and Related Disorders: A Systematic Review and Meta-analysis of Randomized Controlled Trials
Authors: Tamtaji Omid R. , Milajerdi Alireza , Dadgostar Ehsan , Kolahdooz Fariba , Chamani Maryam , Amirani Elaheh , Mirzaei Hamed , Asemi Zatollah
Published: May 2019

Background:

This systematic review and meta-analysis of randomized controlled trials (RCTs) were
performed to determine the effect of quercetin administration on blood pressures and endothelial function among
patients with metabolic syndrome (MetS) and related disorders.

Methods:

We searched systematically online databases including Cochrane Library, EMBASE, MEDLINE, and
Web of Science to identify the relevant RCTs until December 2018. Q-test and I2 statistics were applied to assess
heterogeneity among the included studies. Data were pooled using a random-effects model and weighted mean
difference (WMD) was considered as the overall effect size.

Results:

Out of 284 citations, 8 RCTs were included in the meta-analysis. We found a significant reduction in
systolic blood pressure (SBP) (WMD: -1.69; 95% CI: -3.22, -0.17) following the intake of quercetin supplements.
However, quercetin supplementation did not significantly affect diastolic blood pressure (DBP) (WMD: -3.14;
95% CI: -8.24, 1.95), vascular cell adhesion molecule 1 (VCAM-1) (WMD: -24.49; 95% CI: -53.74, 4.77) and
intercellular adhesion molecule 1 (ICAM-1) (WMD: -5.78; 95% CI: -12.93, 1.38).

Conclusions:

In summary, the current meta-analysis demonstrated that quercetin supplementation significantly
reduced SBP, yet did not affect DBP, VCAM-1 and ICAM-1 among patients with MetS and related disorders.
Strategies for Oral Delivery of Metal-Saturated Lactoferrin
Authors: Gajda-Morszewski Przemysław , Śpiewak-Wojtyła Klaudyna , Oszajca Maria , Brindell Małgorzata
Published: May 2019

Lactoferrin was isolated and purified for the first time over 50-years ago. Since then, extensive studies on the structure and function of this protein have been performed and the research is still being continued. In this mini-review we focus on presenting recent scientific efforts towards the elucidation of the role and therapeutic potential of lactoferrin saturated with iron(III) or manganese(III) ions. The difference in biological activity of metal-saturated lactoferrin vs. the unmetalated one is emphasized. The strategies for oral delivery of lactoferrin, are also reviewed, with particular attention to the metalated protein.
Versatile Impact of Serum Proteins on Ruthenium(II) Polypyridyl Complexes Properties - Opportunities and Obstacles
Authors: Mazuryk Olga , Gajda-Morszewski Przemysław , Brindell Małgorzata
Published: May 2019

Ruthenium(II) polypyridyl complexes have been extensively studied for the past few decades
as promising anticancer agents. Despite the expected intravenous route of administration, the interaction
between Ru(II) polypyridyl compounds and serum proteins is not well characterized and vast majority
of the available literature data concerns determination of the binding constant. Ru-protein adducts
can modify the biological effects of the Ru complexes influencing their cytotoxic and antimicrobial
activity as well as introduce significant changes in their photophysical properties. More extensive research
on the interaction between serum proteins and Ru(II) polypyridyl complexes is important for
further development of Ru(II) polypyridyl compounds towards their application in anticancer therapy
and diagnostics and can open new opportunities for already developed complexes.
Mouse Models of Familial Hemiplegic Migraine for Studying Migraine Pathophysiology
Authors: Dehghani Anisa , Karatas Hulya
Published: May 2019

Migraine, an extremely disabling neurological disorder, has a strong genetic component.
Since monogenic migraines (resulting from mutations or changes in a single gene) may help researchers
discover migraine pathophysiology, transgenic mice models harboring gene mutations
identified in Familial Hemiplegic Migraine (FHM) patients have been generated. Studies in these
FHM mutant mice models have shed light on the mechanisms of migraine and may aid in the identification
of novel targets for treatment. More specifically, the studies shed light on how gene mutations,
hormones, and other factors impact the pathophysiology of migraine. The models may also be
of relevance to researchers outside the field of migraine as some of their aspects are relevant to pain
in general. Additionally, because of the comorbidities associated with migraine, they share similarities
with the mutant mouse models of epilepsy, stroke, and perhaps depression. Here, we review the
experimental data obtained from these mutant mice and focus on how they can be used to investigate
the pathophysiology of migraine, including synaptic plasticity, neuroinflammation, metabolite
alterations, and molecular and behavioral mechanisms of pain.
Lipid Based Nanoparticles: Current Strategies for Brain Tumor Targeting
Authors: Mohanta Bibhash C. , Palei Narahari N. , Surendran Vijayaraj , Dinda Subas C. , Rajangam Jayaraman , Deb Jyotirmoy , Sahoo Biswa M.
Published: May 2019

Brain tumors arise from an uncontrolled proliferation of neural tissue cells or supportive glial tissue cells within the brain. The diagnosis and therapy of brain tumor is an extremely challenging task. Moreover, absence of early stage symptoms and consequently delays in diagnosis and therapy worsen its severity. Though in the present days, chemotherapeutic approach is the most common therapeutic approach; still it is linked with several precincts. The blood-brain barrier (BBB) is the main hurdle in delivering most of the chemotherapeutic agents as well as imaging agent that leads to insufficient accumulation of therapeutic / imaging agents at tumor site, and prevents adequate destruction of malignant cells. Recently, lipid based nanoparticles are gaining much more interest and are preferred over polymeric nanoparticles owing to their biodegradability, non-toxicity, excellent tumortargeting ability and ease of surface modification. Certain receptors are over expressed in brain tumor cells which confer an opportunity to the researchers for delivering the chemotherapeutic as well as imaging agent particularly to the tumor cells through the surface modification approach of nanoparticles. Ligands like proteins/peptides, carbohydrates, aptamers, antibodies, and antibody fragments are generally conjugated to the surface of the nanoparticles that bind specifically to an over expressed target on the brain tumor cell surface. In the present review, we discuss the diagnostic and therapeutic application of various types of lipid based nanoparticles such as liposomes, niosomes, solid lipid nanoparticles, nanostructured lipid carrier, lipid nanocapsule, and lipid polymer hybrid nanocarriers along with their various surface modified forms for targeting brain tumor.
Light-matter Interaction Under Intense Field Conditions: Nonlinear Optical Properties of Metallic-dielectric Nanostructures
Authors: Fazio Enza , D'Urso Luisa , Saija Rosalba , Santangelo Saveria , Neri Fortunato
Published: May 2019

Background:

Metallic–dielectric plasmonic nanoparticles have recently aroused great interest
in view of many and novel technological applications, based on the interaction between light
and matter under intense field conditions, in nonlinear integrated photonics and opto-fluidics, thanks
to the possibility of tuning their electronic and optical properties through a fine control of the synthesis
parameters and their nanoparticles under a high-power laser, like the one used during z-scan measures.

Objective:

The goal of this work is the study of nonlinear optical properties (as nonlinear refraction,
scattering, two-photon absorption, optical limiting) of colloids synthesized in different liquid media by
Pulsed laser ablation in liquids (PLAL), which is a photo-assisted synthesis technique ensuring the
formation of stable, contaminant-free colloids directly during the ablation process.

Methods:

Noble metal nanoparticles, metal oxides hybrid nanostructures and silicon-based nanomaterials,
were prepared by nanosecond and picosecond PLAL technique, in different media. The
third-order nonlinear optical (NLO) properties have been studied by the use of a single beam z-scan
technique with Q-switched frequency doubled Nd:YAG laser (λ=532 nm) at 5 ns pulse.

Results:

1) A good stability of the PLAL nanocolloids under a high laser power; 2) the limiting
threshold reduction inducted by the Ag-Au nanoparticles, the increase of the NLO absorption coefficient
β, the reduction of the transmittance/scattering signal and the presence of a pronounced asymmetry
of the peak/valley profile of the metal decorated metal oxide nanomaterials compared to the
separately produced components.

Conclusion:

An intriguing coupling between the nature of the optical limiting response and the
nanostructures rearrangement upon intense field conditions, explaining z-scan data by a classical approach
able to account for the nanoparticles asymmetry and plasmonic effects, are the main results
found.
COMPARATIVE CHARACTERISTICS OF SOFTWARE SYSTEMS FOR ANALYSIS AND PROCESSING OF SPEECH SIGNALS USING WAVELETS
Authors: Dovgal V. M. , Hein Min Zo
Published: May 2019

Objectives.This article is devoted to the problem of processing and analysis of speech signals on the basis of the wavelet transform method, which has become one of the most relevant in recent years.

Method.The growing relevance and undoubted practical value became the reason for the emergence of a large number of software systems that allow the processing of speech signals on the basis of this method. However, each of these systems has significant differences in the interface provided by the processing tools, functions, has a number of advantages and disadvantages. At the moment, a large number of manuals and recommendations for specific software packages have been written, but these materials are fragmented and unsystematic.

Result.This article attempts to systematize the theoretical material and describe the similarities and differences, advantages and disadvantages of the three most popular software systems: 1) MATLAB 6.0/6.1/6.5 Wavelet Toolbox 2/2.1/2.2; 2) Mathcad; 3) Wavelet Explorer of Mathematica.

Conclusion.This article will be useful for specialists dealing with the problem of speech signal processing using the wavelet transform method, as it contains material that has practical value, and will allow to facilitate the work of a specialist related to the selection of the optimal for the implementation of a specific task of the software complex.
SOFTWARE APPLICATION FOR CALCULATING MODELS FORECASTING INNOVATIVE DEVELOPMENT OF INDUSTRIES
Authors: Mirzemagomedova M. M. , Muradov M. M.
Published: May 2019

Objectives. The article is devoted to the development of a software application that allows you to automate methods for collecting and processing information, as well as perform time-consuming analytical calculations. Embarcadero C ++ Builder XE, a visual object-oriented programming language, was used to implement a software application. The software being developed is created to solve the following tasks: a comparative analysis of innovative development indicators for the selected years; selection of a projected indicator, building a regression model; making a forecast with a lead time of 3; determination of the confidence interval; the formation of a graphical display of observable and calculated values, the selected indicator of innovative development.

Method. In a software application, formalized methods were used as a mathematical model, one of which is multiple regression. Regression analysis consists in defining an analytical expression of a relationship in which a change in a single quantity, called a dependent or productive attribute, is due to the influence of one or several independent quantities (factors).

Result. With the help of the developed software product, you can not only automate time-consuming methods of collecting and processing information, but also per-form complex analytical calculations using the multiple regression method.

Conclusion. Embarcadero C ++ Builder XE is by far the latest state-of-the-art technology and C ++ programming environment. With C ++ Builder, XE has become faster to do the job of creating high-quality applications for Windows-based applications, due to the rapid writing of code, new tools and components.
STRESSED CONDITION OF THE WRAPPING WITHOUT-DRIVE HYDROTECHNICAL TUNNEL OF THE CIRCULAR FORM, PROPOSED IN ANISOTROPIC ROCK GROUND
Authors: Bautdinov D. T. , Djamaludinov M. M. , Zhukova K. S.
Published: May 2019

Objectives. The aim of the study is a parametric analysis of the stress-free lining of a pressureless hydraulic tunnel of circular section, and adjacent anisotropic rock from its own weight of the ground medium at different ratios of the elastic characteristics of the ground medium in orthogonal directions using a transversely isotropic medium model.

Method. The calculation of a large-length hydraulic tunnel laid in strong transversely isotropic rocky ground is reduced to the problem of plane deformation of the theory of elasticity for a transversely isotropic medium containing tunnel development. A model of a transversely isotropic medium (a special case of an anisotropic medium) was used, in which the ground in one plane possesses the characteristics of an isotropic medium (the isotropy plane), and in the perpendicular direction, characteristics different from the isotropic medium. The finite element method was used using the ANSYS software package. The sizes and type of the finite element suitable for calculation on the basis of the solution in the program complex of the verification task were previously determined. The Kirsch problem was accepted as the verification problem.

Result. The relative tangential stresses on the outer and inner lining contour, which allow reinforcement of the concrete lining at different depths of the tunnel, are determined. The tangential stresses in the adjacent rock massif are determined, allowing, if necessary, to assess the strength of the soil on the lining contour.

Conclusion. The results of the study showed that the degree of anisotropy of the elastic properties of the soil massif significantly affects the stress state. When designing underground structures, it is neces-sary to take into account the anisotropy of the elastic properties of the soil mass; define in detail the physicomechanical properties of rocky soils and pay special attention to elastic characteristics. Ac-counting for transversal-isotropy leads to both an increase and a decrease in tangential stresses in the lining of the tunnel and in the rocky soil on the lining contour. In some respects, the elastic character-istics in orthogonal directions, in the lining and in the soil on the lining contour, there are no tensile stresses, which favorably affects the operation of the hydraulic tunnel.
SPECIFICS OF FORMATION AND EFFECTIVE USE OF CURRENT ASSETS IN CONSTRUCTION
Authors: Chetin T. E.
Published: May 2019

Objectives. This study is aimed at identifying the specifics of managing current assets in construction enterprises and developing a set of practical measures that can enhance the efficiency of their use.

Method. In the course of the study, a system approach was taken, comparative and functional-cost analysis methods.

Result. It is shownthatthe specifics of current assetformation in construction industry is to be taken into account when developing a conceptual basis for managinga construction enterprise. Methodological approaches to the estimation of current assets are described, the most effective of which facilitate the optimal choice of sources, forms and volume of attracting current assets into construction industry. A set of practical measures for organizing a system of current asset management in construction enterprises is proposed. These measures are expected to provide for the rational formation and use of all the constituent components of this system.

Conclusion. The methodological approaches to the estimation of current assets, criteria for making managerial decisions, management strategy development stage sand methodological provisions for the organisation of the management of current assets presented in this papercan be used as a methodological basis for managing the working assets of a construction enterprise, thuscontributing to improved management efficiency and creating conditions for sustainable functionality. Every managerial decisionrelated to determining the level of financial assets, accounts receivable and inventories should be considered from the standpoint of both the profitability of these assets and the optimal structure of current assets, thus requiring respective management levers. The implementation of the basic requirements for the management of current assets necessitates the application of anti-risk expert-analytical procedures, including those related to the functioning of the corporate information management system.
Study of The Initiation of Green Banking Practices at State-owned Bank
Authors: Handajani Lilik , Rifai Ahmad , Husnan L. Hamdani
Published: May 2019

AbstractThis study aims to describe the initiation of green banking practices at state-owned banks by identifying reporting issues and the level of green banking disclosure as well as formulating the reporting domain and indicators of its activities. Content analysis is carried out on information related to green banking activities report in the annual report of BUMN banks for the period 2015-2017. The research findings reveal that state-owned banks have initiated green banking practices. The practices come in various forms of activity due to the absence of reporting guidelines and the trend to report green banking activities that have been increasing over the past 3 years.  Indicators of green banking activities in state-owned banks can be grouped into several reporting domains namely, green products, green operations, green customers and green policies. The implications of the study argue that the initiation of green banking practices in the practice of green banking at state-owned banks can be a role model for initiating environmentally friendly bank practices. Moreover, it is expected that environmentally friendly bank practices can minimize business risks by reducing environmental and social risks by harmonizing economic, environmental and social interests in towards achieving sustainable finance. Keywords: state-owned bank, green banking, sustainable finance Kajian Tentang Inisiasi Praktik Green Banking Pada Bank BUMNAbstractPenelitian ini bertujuan untuk mendeskripsikan inisiasi praktik green banking pada bank BUMN dengan mengidentifikasi isu-isu pelaporan dan tingkat pengungkapan green banking serta merumuskan domain pelaporan dan indikator kegiatannya. Analisis isi dilakukan terhadap informasi yang berkaitan dengan pelaporan aktivitas green banking pada laporan tahunan bank BUMN periode 2015-2017. Temuan penelitian mengungkapkan bank BUMN telah melakukan inisiasi praktik green banking dengan bentuk aktivitas yang beragam karena belum adanya pedoman pelaporannya dan terjadi kecenderungan pelaporan aktivitas green banking yang semakin meningkat dalam kurun waktu 3 tahun terakhir.  Indikator kegiatan green banking pada bank BUMN dapat dikelompokkan dalam domain pelaporan yang meliputi green product, green operational, green customer, dan green policy.  Implikasi dari penelitian mengargumentasikan bahwa inisiasi praktik green banking pada bank BUMN dapat menjadi role model inisiasi praktik bank ramah lingkungan untuk meminimalkan risiko bisnis dengan mengurangi risiko lingkungan dan sosial dengan menyelaraskan kepentingan ekonomi, lingkungan dan sosial dalam mewujudkan keuangan berkelanjutan. Kata kunci: bank BUMN, perbankan hijau, keuangan berkelanjutan
The Assessment of Bankruptcy Potential of Sharia Rural Banks in Indonesia
Authors: Pratiwi Amelia , Puspita Baiq Nurlita Dwi , Wahyudi Sony
Published: May 2019

Abstract:This investigation is intended to assess the possibility of financial problems in Sharia Rural Banks (SBRs) in Indonesia. The financial ratio approach is chosen to measure the financial distress potential of SRBs which assesses the profitability, liquidity, efficiency and capital adequacy of 166 banks from 2013 to 2016. The model of panel estimation uses discriminant analysis is utilized in predicting financial distress in Indonesian SRBs. The outcomes of this research are, firstly, liquidity and efficiency are the most prominent variables in predicting financial difficulties in SRBs. The second is in further analysis of liquidity shows that most SRBs are very aggressive in disbursing credit to small and medium enterprises (SMEs), which are riskier than other economic sectors. In addition, a deeper analysis of bank efficiency indicates that the highest expense component of SRBs' other operating costs is employee and administration costs. Keywords: financial distress, financial ratios, Sharia rural banks, discriminant analysisPengujian Potensi Kebangkrutan Grup Bank Pembiayaan Rakyat Syariah di IndonesiaAbstrakStudi ini bertujuan untuk menilai kemungkinan terjadinya masalah keuangan pada Bank Perkreditan Rakyat Syariah (BPRS) di Indonesia. Pendekatan rasio keuangan dilakukan untuk mengukur kemungkinan terjadinya financial distress yang menilai dari sisi profitabilitas, likuiditas, efisiensi dan kecukupan modal dari 166 bank selama 2013 hingga 2016. Model estimasi panel menggunakan analisis diskriminan diterapkan dalam memprediksi financial distress pada BPRS Indonesia. Hasilnya adalah, pertama, likuiditas dan efisiensi adalah variabel yang paling signifikan dalam memprediksi kesulitan keuangan di BPRS. Kedua, dalam analisis likuiditas lebih lanjut menunjukkan bahwa sebagian besar BPRS cukup agresif dalam mendistribusikan pembiayaan kepada usaha kecil dan menengah (UKM), yang lebih berisiko di bandingkan sektor ekonomi lainnya. Selain itu, analisis yang lebih dalam tentang efisiensi bank menunjukkan bahwa komponen biaya tertinggi dari biaya operasional lain BPRS secara rata-rata adalah biaya pegawai atau karyawan dan administrasi. Kata kunci: financial distress, rasio keuangan, BPRS, analisis diskriminan
Developing SMS content to promote Pap triage: a qualitative exploration (Preprint)
Authors: Sanchez Antelo Victoria , Kohler Racquel E , Curotto Mariana , Viswanath Kasisomayajula , Paolino Melisa , Arrossi Silvina
Published: May 2019

BACKGROUND

SMS interventions are effective in promoting a variety of health behaviors; however, there is scarce information regarding SMS use for cervical cancer screening and follow-up care. The ATICA Study (Application of Communication and Information Technologies to Self-Collection, for its initials in Spanish) aims to evaluate a multi-component mHealth intervention to increase triage adherence among women with HPV-positive self-collected tests in Jujuy, Argentina. Here, we describe the formative results used to design the content of the SMS to be tested in the trial.

OBJECTIVE

To understand cultural and contextual elements, women’s beliefs and perceptions regarding the use of SMS by the health care system, and women’s preferences about the message content.

METHODS

We conducted five focus groups, stratified by rural/urban residence and age. All participants were aged 30 or older and had performed HPV self-collection. Participatory techniques, including brainstorming, card-based classification and discussions were used to debate the advantages and disadvantages of messages. We openly coded the discussions for agreements and preferences regarding SMS content. Messages for both HPV negative and positive women were validated through interviews with health authorities and 14 HPV-tested women. The final versions of the messages were pilot tested.

RESULTS

Forty-eight women participated in the FGs. Participant women rejected receiving both negative and positive HPV-results by SMS, as for them delivery of results should be done in a face-to-face encounter with health professionals. They stressed the importance of SMS content informing them that results were available to pick them up while highlighting the link they had with CHWs and the nearest health center. Women considered that a personalized SMS was important, as well as the use of a formal yet warm tone. Due to confidentiality issues, not using the word HPV was also a key component of the desired SMS content; therefore the final message included the term “self-collection” without mention of HPV infection. Results from the validation stage and pilot test showed high acceptability of the final version of the message.

CONCLUSIONS

Results suggest SMS is accepted when notifying women about HPV result availability, but it should not replace the delivery of results in face-to-face, doctor-patient encounters. Messages must be tailored and have a persuasive tone in order to motivate women to adhere to triage.

CLINICALTRIAL

ClinicalTrials.gov, NCT03478397. Registered on March 20th, 2018.
NIH Grants Proposing Specialized Smartphone Intervention Apps: 2014 to 2018 (Preprint)
Authors: Hansen William B. , Scheier Lawrence M.
Published: May 2019

BACKGROUND

The widespread adoption of mobile and smartphones provides researchers with expanded opportunities for implementing behavioral and health-related interventions. The National Institutes of Health (NIH) funds competitive technology-based grant applications to support health promotion consistent with its mission. Funded grants represent the state-of-the-art science and therefore are expected to anticipate the progression of health promotion and disease prevention research in the near future.

OBJECTIVE

The objective of this paper is to examine the different kinds of smartphone-based intervention apps funded through NIH Institutes during the five-year period between 2014 and 2018.

METHODS

We queried the public domain NIH Reporter to identify candidate grants that addressed mHealth and involved implementation of smartphone applications. From 1,524 potential grants, we identified 399 that met the requisite of including an intervention app. Grants from 20 Institutes under the NIH umbrella were included. Each grant’s abstract was analyzed to understand the rationale behind the app and focus of intervention, in addition year of funding, and first-year award amount, type of activity (e.g. R01, R34, etc.), specific strategy, intended outcome, and target population were also noted.

RESULTS

We identified 13 categories of strategies employed in the different intervention apps. Most grants included either one (36.6%) or two (37.8%) intervention approaches. These included cognitive and behavioral therapies (67 apps), enhanced motivation (49 apps), mindfulness training (17 apps), norm setting (7 apps), skills training (84 apps), gaming and gamification (56 apps), social support and social networking (58 apps), facilitating, reminding and referring (60 apps), education and information (84 apps), monitoring and feedback (191 apps), contingency management (23 apps), artificial intelligence (57 apps), and bionic adaptation (33 apps). The most frequently observed grant types included SBIR/STTR grants (40.9%) and R01s (26.1%). The number of grants funded increase through the five-year period from 60 in 2014 to 112 in 2018.

CONCLUSIONS

Smartphone intervention apps are increasingly competitive for NIH funding. They utilize a wide diversity of intervention strategies and substantive foci that collectively have significant potential for use in applied health promotion settings.
Developing a Reproducible Microbiome Data Analysis Pipeline Using the Amazon Web Services Cloud for a Cancer Research Group: Proof-of-Concept Study (Preprint)
Authors: Bai Jinbing , Jhaney Ileen , Wells Jessica
Published: May 2019

BACKGROUND

Cloud computing for microbiome data sets can significantly increase working efficiencies and expedite the translation of research findings into clinical practice. The Amazon Web Services (AWS) cloud provides an invaluable option for microbiome data storage, computation, and analysis.

OBJECTIVE

The goals of this study were to develop a microbiome data analysis pipeline by using AWS cloud and to conduct a proof-of-concept test for microbiome data storage, processing, and analysis.

METHODS

A multidisciplinary team was formed to develop and test a reproducible microbiome data analysis pipeline with multiple AWS cloud services that could be used for storage, computation, and data analysis. The microbiome data analysis pipeline developed in AWS was tested by using two data sets: 19 vaginal microbiome samples and 50 gut microbiome samples.

RESULTS

Using AWS features, we developed a microbiome data analysis pipeline that included Amazon Simple Storage Service for microbiome sequence storage, Linux Elastic Compute Cloud (EC2) instances (ie, servers) for data computation and analysis, and security keys to create and manage the use of encryption for the pipeline. Bioinformatics and statistical tools (ie, Quantitative Insights Into Microbial Ecology 2 and RStudio) were installed within the Linux EC2 instances to run microbiome statistical analysis. The microbiome data analysis pipeline was performed through command-line interfaces within the Linux operating system or in the Mac operating system. Using this new pipeline, we were able to successfully process and analyze 50 gut microbiome samples within 4 hours at a very low cost (a c4.4xlarge EC2 instance costs $0.80 per hour). Gut microbiome findings regarding diversity, taxonomy, and abundance analyses were easily shared within our research team.

CONCLUSIONS

Building a microbiome data analysis pipeline with AWS cloud is feasible. This pipeline is highly reliable, computationally powerful, and cost effective. Our AWS-based microbiome analysis pipeline provides an efficient tool to conduct microbiome data analysis.
Cost-Effectiveness of Therapist-Guided Internet-Based Cognitive Behavioral Therapy for Stress-Related Disorders: Secondary Analysis of a Randomized Controlled Trial (Preprint)
Authors: Lindsäter Elin , Axelsson Erland , Salomonsson Sigrid , Santoft Fredrik , Ljótsson Brjánn , Åkerstedt Torbjörn , Lekander Mats , Hedman-Lagerlöf Erik
Published: May 2019

BACKGROUND

Stress-related disorders are associated with significant suffering, functional impairment, and high societal costs. Internet-based cognitive behavioral therapy (ICBT) is a promising treatment for stress-related disorders but has so far not been subjected to health economic evaluation.

OBJECTIVE

The objective of this study was to evaluate the cost-effectiveness and cost-utility of ICBT for patients with stress-related disorders in the form of adjustment disorder (AD) or exhaustion disorder (ED). We hypothesized that ICBT, compared with a waitlist control (WLC) group, would generate improvements at low net costs, thereby making it cost-effective.

METHODS

Health economic data were obtained in tandem with a randomized controlled trial of a 12-week ICBT in which patients (N=100) were randomized to an ICBT (n=50) or a WLC (n=50) group. Health outcomes and costs were surveyed pre- and posttreatment. We calculated incremental cost-effectiveness ratios (ICERs) based on remission rates and incremental cost-utility ratios (ICURs) based on health-related quality of life. Bootstrap sampling was used to assess the uncertainty of our results.

RESULTS

The ICER indicated that the most likely scenario was that ICBT led to higher remission rates compared with the WLC and was associated with slightly larger reductions in costs from pre- to posttreatment. ICBT had a 60% probability of being cost-effective at a willingness to pay (WTP) of US $0 and a 96% probability of being cost-effective at a WTP of US $1000. The ICUR indicated that ICBT also led to improvements in quality of life at no net societal cost. Sensitivity analyses supported the robustness of our results.

CONCLUSIONS

The results suggest that ICBT is a cost-effective treatment for patients suffering from AD or ED. Compared with no treatment, ICBT for these patients yields large effects at no or minimal societal net costs.

CLINICALTRIAL

ClinicalTrials.gov NCT02540317; https://clinicaltrials.gov/ct2/show/NCT02540317
¿Es necesariamente verdadero que si un enunciado geométrico es verdadero, es necesariamente verdadero?
Authors: Méndez Pinto Emilio
Published: May 2019

En este ensayo respondo negativamente a la pregunta del título al sostener que el enunciado “La suma de los ángulos internos de un triángulo es igual a 180°” es contingentemente verdadero. Para ello, intento refutar la tesis de Ramsey de que las verdades geométricas necesariamente son verdades necesarias (Ramsey 2013, p. 13), así como la tesis de Kripke de que no puede haber proposiciones matemáticas contingentemente verdaderas (Kripke 2005, p. 156). Además, recurriendo a la concepción fregeana sobre lo a priori y lo a posteriori (Frege 1980, p. 5), sostengo que hay verdades geométricas que pueden ser a priori sin tener que serlo.
Falsa oposición: cinco enigmas para el intérprete
Authors: Seoane José
Published: May 2019

Interpretar un texto filosófico supone procurar descifrar su significado, identificar sus tesis y aislar sus argumentos. Desarrollar un texto filosófico, en cambio, consiste en seleccionar ciertas ideas fundamentales, valiosas aunque necesitadas de afinamiento, y lograr su mejor formulación. Lógica Viva, la obra filosófica más importante de Vaz Ferreira, ha merecido diversas interpretaciones y desarrollos. En particular, esto ha ocurrido con su capítulo dedicado a la falsa oposición. El objetivo principal de esta nota es reconocer cinco enigmas en tal capítulo, relevantes para una interpretación y decisivos para ciertos desarrollos. Expresados sucintamente en forma de interrogantes los mismos podrían exponerse así: ¿cómo entender, en este contexto, oposición?, ¿cuál es el papel que, en la caracterización del paralogismo, juega la ejemplificación?, ¿cuán relevantes son, en tal labor, las dimensiones literal y no-literal?, ¿en qué consiste el “mal argumento” que se considera falsa oposición?, ¿cómo equivoca y cómo persuade el mismo?  Se recurre además a un modelo de análisis argumental (denominado M), inspirado en las ideas de Vaz Ferreira, a los efectos de mostrar cómo su uso auspicia, por una parte, un tratamiento explícito de estos enigmas y, por otra, desafiado por estos, cómo su aplicación pueda quizá sugerir líneas prometedoras de interpretación y/o desarrollo. Estas páginas pretenden asimismo ilustrar ciertas relaciones entre ambas actividades.
El matrimonio entre el cine y la filosofía: Apuntes sobre la metafilosofía de Stanley Cavell
Authors: Ruiz Moscardó Javier
Published: May 2019

En este trabajo expondremos brevemente algunas características fundamentales de la concepción de la filosofía defendida por Stanley Cavell, con especial atención a su reivindicación del cine como agente filosófico de pleno derecho. Nuestra intención es presentar las claves del planteamiento metafilosófico de Cavell, con el objetivo de desarrollar posteriormente su concepción del arte cinematográfico como un tipo de praxis filosófica particular, fundada en la tesis de que el cine puede concebirse como un “medio de pensamiento” adecuado para afrontar sendos problemas filosóficos.
The Determinants of Sovereign Credit Ratings: Indonesia and Its Neighborhood Countries 1998-2016
Authors: Solikin Akhmad , Michel Gerry
Published: May 2019

The aim of this research is to study the determinants of sovereign credit ratings of Indonesia andits neighborhood countries in the period of 1998-2016. Using secondary data and analyzed usingordered probit, it is found that every credit rating agency has its own variables influencing to itspublished credit ratings.In general, for Indonesia and its neighborhood countries, the variables withsignificant and positive relationship are fiscal balance and current account deficit to GDP, freedomindex, and GDP per capita; while the variables with significant and negative relationship are externaldebt to GNI and real exchange rate. Gross domestic savings to GDP influences credit ratings inboth ways. Interestingly, inflation does not affect the credit ratings. Indonesia and neighborhoodgovernments could use this information to manage their macroeconomic indicators in order to getfavorable ratings from credit rating agencies.
Quantum-assisted quantum compiling
Authors: Khatri Sumeet , LaRose Ryan , Poremba Alexander , Cincio Lukasz , Sornborger Andrew T. , Coles Patrick J.
Published: May 2019

Compiling quantum algorithms for near-term quantum computers (accounting for connectivity and native gate alphabets) is a major challenge that has received significant attention both by industry and academia. Avoiding the exponential overhead of classical simulation of quantum dynamics will allow compilation of larger algorithms, and a strategy for this is to evaluate an algorithm's cost on a quantum computer. To this end, we propose a variational hybrid quantum-classical algorithm called quantum-assisted quantum compiling (QAQC). In QAQC, we use the overlap between a target unitaryUand a trainable unitaryVas the cost function to be evaluated on the quantum computer. More precisely, to ensure that QAQC scales well with problem size, our cost involves not only the global overlapTr(V†U)but also the local overlaps with respect to individual qubits. We introduce novel short-depth quantum circuits to quantify the terms in our cost function, and we prove that our cost cannot be efficiently approximated with a classical algorithm under reasonable complexity assumptions. We present both gradient-free and gradient-based approaches to minimizing this cost. As a demonstration of QAQC, we compile various one-qubit gates on IBM's and Rigetti's quantum computers into their respective native gate alphabets. Furthermore, we successfully simulate QAQC up to a problem size of 9 qubits, and these simulations highlight both the scalability of our cost function as well as the noise resilience of QAQC. Future applications of QAQC include algorithm depth compression, black-box compiling, noise mitigation, and benchmarking.
Multiplexed Quantum Random Number Generation
Authors: Haylock Ben , Peace Daniel , Lenzini Francesco , Weedbrook Christian , Lobino Mirko
Published: May 2019

Fast secure random number generation is essential for high-speed encrypted communication, and is the backbone of information security. Generation of truly random numbers depends on the intrinsic randomness of the process used and is usually limited by electronic bandwidth and signal processing data rates. Here we use a multiplexing scheme to create a fast quantum random number generator structurally tailored to encryption for distributed computing, and high bit-rate data transfer. We use vacuum fluctuations measured by seven homodyne detectors as quantum randomness sources, multiplexed using a single integrated optical device. We obtain a real-time random number generation rate of 3.08 Gbit/s, from only 27.5 MHz of sampled detector bandwidth. Furthermore, we take advantage of the multiplexed nature of our system to demonstrate an unseeded strong extractor with a generation rate of 26 Mbit/s.
PROFESSIONAL DEVELOPMENT OF PMRI TEACHERS FOR INTRODUCING SOCIAL NORMS
Authors: Putri Ratu Ilma Indra , Dolk Maarten , Zulkardi Zulkardi
Published: May 2019

This paper reports implementation results of designing a workshop for mathematics teacher in introducing classroom social norms. The participants are eight mathematics teachers in primary and junior secondary level. Teachers learned and did some activities about social norms during the workshop. First, they watched an example of learning videos about social norms. Then they discussed and shared in the group about their experiences in using social norms in the classroom. Finally, they made a commitment to try their knowledge about social norms in their classroom. This research used the design research method. Data were collected using videotaped, interview, and focus group discussion and were analyzed qualitatively. Results show that: (1) Teachers satisfied in following all activities relating to the social norms in the workshop. (2) Teachers realized that they had used some activities of social norms such as guiding students to communicate, asking questions and giving argumentation. (3) Teachers have more confidence to use social norms in their mathematics classroom.Keywords: Classroom Social Norms, Teacherâ€™s Workshop, Design Research, PMRIÂ DOI: dx.doi.org/10.22342/jme.61.11
ASSESSING SEVENTH GRADERS' MATHEMATICAL LITERACY IN SOLVING PISA-LIKE TASKS
Authors: Dewantara Andi Harpeni , Zulkardi Zulkardi , Darmawijoyo Darmawijoyo
Published: May 2019

This  design research type development study aims at producing a set of PISA-like mathematics task which is valid and practical as well as has the potential effects. Then, activation of fundamental mathematical capabilities underlying mathematical process related to the mathematical literacy as the main potential effect of the developed PISA-like tasks would be the focus on this paper. The subject of this study were 28 seven graders of SMP Negeri 1 Palembang involved in field test. Data collecting techniques used were students' test result and interviews. Overall findings indicate that 10 items of PISA-like mathematics task developed potentially promote students' mathematical literacy within three mathematical processes. The result also shows that the highest percentage of students' achievement was on the interpreting tasks (52.55%). While achievement for employ and formulate tasks were 40.74% and 39.63% respectively.Keywords: PISA-like problems, mathematical literacy, mathematical process, fundamental mathematical capabilites
THE IMPACT OF PROBLEM-BASED LEARNING APPROACH TO SENIOR HIGH SCHOOL STUDENTS' MATHEMATICS CRITICAL THINKING ABILITY
Authors: Widyatiningtyas Reviandari , Kusumah Yaya S. , Sumarmo Utari , Sabandar Jozua
Published: May 2019

The study was report the findings of an only post-test control group research design and aims to analyze the influence of problem-based learning approach, school level, and students' prior mathematical ability to student's mathematics critical thinking ability. The research subjects were 140 grade ten senior high school students coming from excellent and moderate school level. The research instruments a set of mathematical critical thinking ability test, and the data were analyzed by using two ways ANOVA and t-test. The research found that the problem-based learning approach has significant impact to the ability of students' mathematics critical thinking in terms of school level and students' prior mathematical abilities. Furthermore. This research also found that there is no interaction between learning approach and school level, and learning approach and students' prior mathematics ability to students' mathematics critical thinking ability.Keywords: problem-based learning, mathematical critical thinking ability
ELPSA AS A LESSON DESIGN FRAMEWORK
Authors: Lowrie Tom , Patahuddin Sitti Maesuri
Published: May 2019

This paper offers a framework for mathematics lesson design that is consistent with the way we learn about, and discover, most things in life. In addition, the framework provides a structure for identifying how mathematical concepts and understanding are acquired and developed. This framework is called ELPSA and represents five learning components, namely: Experience, Language, Pictorial, Symbolic and Applications. This framework has been used in developing lessons and teacher professional programs in Indonesia since 2012 in cooperation with the World Bank. This paper describes the theory that underlines the framework in general and in relation to each inter-connected component. Two explicit learning sequences for classroom practice are described, associated with Pythagoras theorem and probability. This paper then concludes with recommendations for using ELPSA in various institutional contexts.Keywords: ELPSA, lesson design framework, Pythagoras theorem, probabilityÂ DOI: dx.doi.org/10.22342/jme.62.77
The mystery of Copernicus’ star catalog (Part one)
Authors: Tolchelnikova S.A.
Published: May 2019

The Copernican catalog differs from the catalogs of previous epochs by transferring the reference point of ecliptic longitudes from the vernal equinox to the star γ Aries. This violation of the tradition which did not influence the catalogs of subsequent epochs, is regarded by N. I. Idelson as an anachronism, and in the opinion of E. P. Fedorov, this idea of Copernicus was ahead of time. Since the contradictions in the evaluation of Copernicus’ works are inherent in the literature of the 20th century, it is necessary to recall the pre-Copernican astronomy and refer to the text of his works. Our study consists of three parts (papers). The first one is devoted to the period from the studying the motion of heavenly bodies upon celestial sphere to passing to the World structure and the movements of the Solar system bodies. Copernicus’s heliocentric theory made invaluable contribution into the solution of this problem, impossible without determining the distances. The previous basis of astronomical observations was increased by 20 thousand times. A similar advance in the determination of distances by a mathematically exact method is hardly possible in the foreseeable future.
Hazırlık Okulu Öğrencilerinin İngilizce Eğitim İhtiyaçları
Authors: KURTULUŞ Fulya , ASAL Zeki
Published: May 2019

Bu çalışmanın amacı, Karadeniz Bölgesinde bulunan bir üniversitenin İngilizce hazırlık okulunda okuyup eğitimin İngilizce olarak verildiği Fen ve Edebiyat Fakültesine kayıt yaptıran öğrencilerin İngilizce eğitim ihtiyaçlarını belirlemektir. Bu amaç doğrultusunda karma yöntem izlenmiş ve toplam 7 öğrenci ve 5 öğretim üyesi ile çalışılmıştır. Öğrencilerle odak gurup görüşmesi yapılırken, öğretim üyeleri ile yarı yapılandırılmış görüşmeler gerçekleştirilmiş ve öğrencilerin İngilizce eğitim ihtiyaçları araştırılmıştır. Araştırma sonuçlarına göre; öğrenciler iletişim becerilerinde (konuşma ve dinleme) ve akademik kelime bilgisi alanlarında eksik durumdadırlar. Bu bilgilere istinaden ise hazırlık eğitim programında konuşma, dinleme ve akademik kelime bilgisine daha çok önem verilmesi gerektiği yapılan öneriler arasındadır.
The Relationships Between Job Embeddedness, Person-Organization Fit, and Turnover Intention
Authors: Ciptaningtyas Albertha Haga , Suyasa P. Tommy Y. S. , Wati Linda
Published: May 2019

This study aim to examine the relationships between job embeddedness, person-organization fit (POF), and turnover intention. Job embeddedness is a variety of conditions that make individuals feel attached to their job and organization. Person-organization fit is the compatibility between the characteristics of individuals and their organizations. Turnover intention is an employee’s conscious desire to leave his or her organization. This study was conducted among employees of a retail company in West Jakarta. The number of participants in this study was 177 employees. Data analysis was performed using Spearman correlation. Results show that job embeddedness was related to person-organization fit and turnover intention. However, there was no relationship between turnover intention and person-organization fit.