bluuebunny/crossref_metadata_2025 huggingface dataset:
The Evolution of Permian Mafic–Ultramafic Magma of the Yunhai Intrusion in the Northern Tianshan, Northwest China, and Its Implications for Cu-Ni Mineralization
Authors: Pei Yuxuan , Chen Mengting , Zhao Yujing , Li Dahai , Chen Jiashun , Chen Zhaoying , Li Xiaojie , Sun Shilin
Published: January 2025

The early Permian mafic–ultramafic intrusion-related Cu-Ni mineralization in Northern Tianshan offers valuable insights into the nature of the mantle beneath the Central Asian Orogenic Belt (CAOB) and enhances the understanding of magmatic sulfide mineralization processes in orogenic environments. The Yunhai intrusion, rich in Cu-Ni sulfides, marks a significant advancement for Cu-Ni exploration in the covered regions of the western Jueluotag orogenic belt in Northern Tianshan. This intrusion is well-differentiated, featuring a lithological assemblage of olivine pyroxenite, hornblende pyroxenite, gabbro, and diorite, and contains about 50 kilotons of sulfides with average grades of 0.44 wt% Ni and 0.62 wt% Cu. Sulfide mineralization occurs predominantly as concordant layers or lenses of sparsely and densely disseminated sulfides within the olivine pyroxenite and hornblende pyroxenite. In situ zircon U-Pb dating for the Yunhai intrusion indicates crystallization ages between 288 ± 1 and 284 ± 1 Ma, aligning with several Cu-Ni mineralization-associated mafic–ultramafic intrusions in Northern Tianshan. Samples from the Yunhai intrusion exhibit enrichment in light rare earth elements (LREE), distinct negative Nb and Ta anomalies, positive εNd(t) values ranging from 2.75 to 6.56, low initial (87Sr/86Sr)i ratios between 0.7034 and 0.7053, and positive εHf(t) values from 9.27 to 15.9. These characteristics, coupled with low Ce/Pb (0.77–6.55) and Nb/U (5.47–12.0) ratios and high Ti/Zr values (38.7–102), suggest very restricted amounts (ca. 5%) of crustal assimilation. The high Rb/Y (0.35–4.27) and Th/Zr (0.01–0.03) ratios and low Sm/Yb (1.47–2.32) and La/Yb (3.10–7.52) ratios imply that the primary magma of the Yunhai intrusion likely originated from 2%–10% partial melting of weak slab fluids–metasomatized subcontinental lithospheric mantle (peridotite with 2% spinel and/or 1% garnet) in a post-collisional environment. The ΣPGE levels in the Yunhai rocks and sulfide-bearing ores range from 0.50 to 54.4 ppb, which are lower compared to PGE-undepleted Ni-Cu sulfide deposits. This PGE depletion in the Yunhai intrusion’s parental magma may have been caused by early sulfide segregation from the primary magma at depth due to the high Cu/Pd ratios (43.5 × 103 to 2353 × 103) of all samples. The fractional crystallization of minerals such as olivine and pyroxene might be a critical factor in provoking significant sulfide segregation at shallower levels, leading to the extensive disseminated Cu-Ni mineralization at Yunhai. These characteristics are similar to those of typical deposits in the eastern section of the Jueluotage orogenic belt (JLOB), which may indicate that the western and eastern sections of the belt have the same ore-forming potential.
MXene-Reinforced Composite Cryogel Scaffold for Neural Tissue Repair
Authors: Zoughaib Mohamed , Avdokushina Svetlana , Savina Irina N.
Published: January 2025

The development of effective materials for neural tissue repair remains a major challenge in regenerative medicine. In this study, we present a novel MXene-reinforced composite cryogel scaffold designed for neural tissue regeneration. MXenes, a class of two-dimensional materials with high conductivity and biocompatibility, were integrated into a polyvinyl alcohol (PVA) matrix via cryopolymerization to form a macroporous, mechanically stable scaffold. The morphology, mechanical properties, and swelling behavior of the cryogel with different MXene contents have been assessed. The effects of MXene on the viability/proliferation and differentiation of neural cells (PC-12) cultured in the composite cryogel were elucidated. The MXene/PVA cryogel demonstrated excellent cell-supporting potential, with MXene not only showing no toxicity but also promoting the proliferation of cultured PC-12. Additionally, MXene induced a neuritogenesis-like process in the cells as evidenced by morphological changes and the enhanced expression of the neural marker β-III-tubulin. The neuroprotective properties of the MXene component were revealed by the alleviation of oxidative stress and reduction of intracellular ROS levels. These findings highlight the potential of MXene-embedded PVA cryogel as a promising material that can be further used in conjunction with electrostimulation therapy for advancing strategies in neural tissue engineering.
On-Resin Selenopeptide Catalysts: Synthesis and Applications of Enzyme-Mimetic Reactions and Cyclization of Unsaturated Carboxylic Acids
Authors: Iwaoka Michio , Maese Yua , Abe Kasumi
Published: January 2025

Selenium reagents are useful for selenoenzyme-mimicking reactions, as well as for organic synthesis. However, the reaction waste containing selenium frequently smells unpleasant and exhibits serious toxicity. Herein, we have developed new-type on-resin selenium reagents, H-UXX···-PAM (5) and Ac-(X)U*XX···-PAM (6), where U and U* represent selenocysteine (U) and p-methoxybenzyl (PMB)-protected U, respectively, as recyclable catalysts, in which U-containing peptide chains are linked to the polystyrene resin PAM. Synthesized on-resin selenopeptides 5a–g with a variable amino acid sequence were evaluated for their glutathione peroxidase (GPx)-like activity using the UV and 1H NMR methods, using the reaction between dithiothreitol (DTTred) and H2O2 in methanol. It was found that the intramolecular interaction between U and a basic amino acid residue, such as histidine (H) and lysine (K), enhances peroxidase activity through the formation of an NH···Se hydrogen bond. On the other hand, the catalytic activity of 6a–d was evaluated in the oxidative cyclization of β,γ-unsaturated acids (7) into α,β-unsaturated lactones (8). Although the yield of 8 was significantly decreased after second- or third-round reaction, due to detachment of the selenium moiety from the resin, the results demonstrated reusability, as well as a substrate scope of 6 as a catalyst. Since U is a natural amino acid, on-resin selenopeptides are potential targets as novel-type green redox catalysts.
The Pharmaceutical Industry in 2024: An Analysis of the FDA Drug Approvals from the Perspective of Molecules
Authors: de la Torre Beatriz G. , Albericio Fernando
Published: January 2025

The U.S. Food and Drug Administration (FDA) has authorized 50 new drugs in 2024, which matches the average figure for recent years (2018–2023). The approval of 13 monoclonal antibodies (mAbs) sets a new record, with these molecules accounting for more than 25% of all drugs authorized this year. Three proteins have been added to the list of biologics, and with the inclusion of four TIDES (two oligonucleotides and two peptides), only one in three approved drugs this year is a small molecule. As of 2023, no antibody-drug conjugates (ADCs) have reached the market this year. Two deuterated drugs have been approved, bringing the total approvals for this class of compounds to four. This year saw the authorization of two more PEGylated drugs—both peptides—highlighting a renewed interest in this strategy for extending drug half-life, despite the setback caused by the withdrawal of peginesatide from the market in 2014 due to adverse side effects. N-aromatic heterocycles and fluorine atoms are present in two-thirds of all the small molecules approved this year. Herein, the 50 new drugs authorized by the FDA in 2024 are analyzed exclusively on the basis of their chemical structure. They are classified as the following: biologics (antibodies, proteins), TIDES (oligonucleotides and peptides), combined drugs, natural products, F-containing molecules, nitrogen aromatic heterocycles, aromatic compounds, and other small molecules.
Validation of a Smartphone Application for Monitoring Circadian Appetite: A Randomized Crossover Trial in Free-Living and Controlled Settings
Authors: Tsameret Shani , Froy Oren
Published: January 2025

Background/Objectives: Appetite is affected by the circadian clock and exhibits diurnal variations. Nevertheless, accurately measuring subjective appetite throughout the day in a free-living setting poses a challenge. This study presents the validation of a novel smartphone application designed to capture, process and analyze circadian appetite fluctuations in a free-living setting. Methods: Twenty-four healthy participants (ages 38.34 ± 3.2 years) completed this randomized crossover study. Participants completed subjective appetite questionnaires every 30 min in a free-living environment, starting from waking hours until bedtime, using visual analog scale (VAS) via the pen and paper (PP) method and the new smartphone application (App). In addition, on two experimental days, separated by a week of washout, participants were provided either a high-energy breakfast (850 kcal) or a low-energy breakfast (250 kcal). Participants completed the appetite questionnaires using both methods every 30 min for 4 h, followed by an ad libitum lunch. Results: The high-energy breakfast led to significantly increased fullness sensation and decreased hunger, desire to eat, prospective consumption, and appetite score compared with the low-energy breakfast. There was no significant difference between the methods (PP and App) in all measured parameters under both the free-living environment and the controlled environment. Additionally, Bland–Altman analysis revealed a high degree of agreement between the PP and App methods. Moreover, most participants rated the App as the preferred method regardless of age. Conclusions: Our findings show that the new smartphone application is a valid, reliable tool for measuring subjective appetite, suitable for use in chrononutritional studies conducted in a free-living environment and controlled settings.
Dual-Labeled Small Peptides in Cancer Imaging and Fluorescence-Guided Surgery: Progress and Future Perspectives
Authors: Minges Paul , Eder Matthias , Eder Ann-Christin
Published: January 2025

Dual-labeled compounds that combine radiolabeling and fluorescence labeling represent a significant advancement in precision oncology. Their clinical implementation enhances patient care and outcomes by leveraging the high sensitivity of radioimaging for tumor detection and taking advantage of fluorescence-based optical visualization for surgical guidance. Non-invasive radioimaging facilitates immediate identification of both primary tumors and metastases, while fluorescence imaging assists in decision-making during surgery by offering a spatial distinction between malignant and non-malignant tissue. These advancements hold promise for enhancing patient outcomes and personalization of cancer treatment. The development of dual-labeled molecular probes targeting various cancer biomarkers is crucial in addressing the heterogeneity inherent in cancer pathology and recent studies had already demonstrated the impact of dual-labeled compounds in surgical decision-making (NCT03699332, NCT03407781). This review focuses on the development and application of small dual-labeled peptides in the imaging and treatment of various cancer types. It summarizes the biomarkers targeted to date, tracing their development from initial discovery to the latest advancements in peptidomimetics. Through comprehensive analysis of recent preclinical and clinical studies, the review demonstrates the potential of these dual-labeled peptides to improve tumor detection, localization, and resection. Additionally, it highlights the evolving landscape of dual-modality imaging, emphasizing its critical role in advancing personalized and effective cancer therapy. This synthesis of current research underscores the promise of dual-labeled peptides in enhancing diagnostic accuracy and therapeutic outcomes in oncology.
Exosome Source Matters: A Comprehensive Review from the Perspective of Diverse Cellular Origins
Authors: Chen Yiru , Qi Weikun , Wang Zhenghao , Niu Feng
Published: January 2025

Exosomes have emerged as promising therapeutic agents in regenerative medicine. This review introduces a novel cell type-oriented perspective to systematically analyze exosomal properties in regenerative therapies. To our knowledge, this review is the first to comprehensively compare exosomes based on cellular source type, offering unprecedented insights into selecting optimal exosome producers for targeted regenerative applications. Factors beyond cellular origin influencing exosomal therapeutic efficacy, such as donor sites and collection methods, are also explored here. By synthesizing key advances, we propose promising research directions in the end. We aim to accelerate the development of more effective exosome-based regenerative therapies and highlight underexplored directions in this rapidly evolving field.
Iodinated Copper–Cysteamine Nanoparticles as Radiosensitizers for Tumor Radiotherapy
Authors: Zhang Miaomiao , Yang Yu , Xu Ying , Wang Jie , Li Shihong
Published: January 2025

Background/Objectives: Radiotherapy is a widely applied first-line clinical treatment modality of cancer. Copper–cysteamine (Cu-Cy) nanoparticles represent a new type of photosensitizer that demonstrates significant anti-tumor potential by X-ray-induced photodynamic therapy. Iodide is a high-Z element with superior X-ray absorption ability and has the β-decay radiotherapeutic nuclide, 131I, which emits Cherenkov light. In this study we aimed to investigate the X-ray-induced photodynamic therapy potential of iodinated Cu-Cy (Cu-Cy-I) nanoparticles and also explore the local treatment efficacy of 131I-labeled Cu-Cy-I ([131I]Cu-Cy-I) nanoparticles. Methods: The synthesis of [131I]Cu-Cy-I nanoparticles was performed with [131I]I− anions. The in vitro radiobiological effects on tumor cells incubated with Cu-Cy-I nanoparticles by X-ray irradiation were investigated. The in vivo tumor growth-inhibitory effects of the combination of Cu-Cy-I nanoparticles with X-ray radiotherapy and [131I]Cu-Cy-I nanoparticles were evaluated with 4T1 tumor-xenografted mice. Results: The in vitro experiment results indicated that the X-ray irradiation with the presence of Cu-Cy-I nanoparticles produced a higher intracellular reactive oxygen species (ROS) level and more DNA damage of 4T1 cells and showed a stronger tumor cell killing ability compared to X-ray irradiation alone. The in vivo experimental results with 4T1 breast carcinoma-bearing mice showed that the combination of an intratumoral injection of Cu-Cy-I nanoparticles and X-ray radiotherapy enhanced the tumor growth-inhibitory effect and prolonged the mice’s lives. Conclusions: Cu-Cy-I nanoparticles have good potential as new radiosensitizers to enhance the efficacy of external X-ray radiotherapy. However, the efficacy of local treatment with [131I]Cu-Cy-I nanoparticles at a low 131I dose was not verified. The effective synthesis of smaller sizes of nanoparticles is necessary for further investigation of the radiotherapy potential of [131I]Cu-Cy-I nanoparticles.
Non-Targeted Metabolome Analysis with Low-Dose Selenate-Treated Arabidopsis
Authors: Li Hongqiao , Mori Tetsuya , Moriyama Rintaro , Fujita Moeka , Hatanaka Genki , Shiotsuka Naoki , Hosomi Ryota , Maruyama-Nakashita Akiko
Published: January 2025

Selenate, the most common form of selenium (Se) in soil environments, is beneficial for higher plants. Selenate is similar to sulfate in terms of the structure and the manner of assimilation by plants, which involves the reduction of selenate to selenide and the replacement of an S moiety in the organic compounds such as amino acids. The nonspecific incorporation of seleno-amino acids into proteins induce Se toxicity in plants. Selenate alters the plant metabolism, particularly the S metabolism, which is comparable to the responses to S deficiency (−S). However, previous analyses involved high concentrations of selenate, and the effects of lower selenate doses have not been elucidated. In this study, we analyzed the metabolic changes induced by selenate treatment through a non-targeted metabolome analysis and found that 2 µM of selenate decreased the S assimilates and amino acids, and increased the flavonoids, while the glutathione levels were maintained. The results suggest that the decrease in amino acid levels, which is not detected under −S, along with the disruptions in S assimilation, amino acid biosynthesis pathways, and the energy metabolism, present the primary metabolic influences of selenate. These results suggest that selenate targets the energy metabolism and S assimilation first, and induces oxidative stress mitigation, represented by flavonoid accumulation, as a key adaptive response, providing a novel, possible mechanism in plant stress adaptation.
Promising Biotechnological Applications of the Artificial Derivatives Designed and Constructed from Plant microRNA Genes
Authors: Erokhina T. N. , Ryabukhina Ekaterina V. , Lyapina Irina S. , Ryazantsev Dmitry Y. , Zavriev Sergey K. , Morozov Sergey Y.
Published: January 2025

MicroRNAs (miRNAs) are small regulatory RNAs that are expressed in a tissue-specific manner during the development of plants and animals. The genes of miRNAs have been found to produce the following two products: (i) primary transcripts of these genes (pri-miRNA) are processed to give rise to mature miRNA, and (ii) in some cases, the pri-miRNA molecules can be translated to form small peptides, named as miPEPs. Gene silencing by artificial microRNAs (amiRNAs) is one of the potential crucial methods for the regulation of desired genes to improve horticultural plants. Likewise, external application of chemically synthesized miPEPs may help plants to resist biotic/abiotic stresses and grow faster. These potent and reliable derivatives of miRNA genes can be applied for improving useful traits in crop plants. This review summarizes the progress in research on the artificial gene derivatives involved in regulating plant development, virus and pest diseases, and abiotic stress resistance pathways. We also briefly discuss the molecular mechanisms of relevant target genes for future research on breeding in plants. In general, this review may be useful to researchers who are implementing amiRNA and miPEP for accelerating breeding programs and developmental studies in crop plants.
Enhanced Stability of Lactobacillus paracasei Aspartate Ammonia-Lyase via Electrospinning for Enzyme Immobilization
Authors: Hsieh Chun-Yen , Huang Yi-Hao , Yu Yu-Ting , Chang Kai-Wei , Chen Yung-Ju , Hsieh Lu-Sheng
Published: January 2025

This study investigates the immobilization of Lactobacillus paracasei AAL (LpAAL) protein onto polyvinyl alcohol/nylon 6/chitosan nanofiber membranes using dextran polyaldehyde as a biodegradable cross-linker. Immobilization enhanced the enzyme’s stability, shifting its optimal reaction conditions from 40 °C to 45 °C and pH from 8.0 to 8.5. While immobilization slightly reduced its catalytic efficiency, it significantly improved enzyme stability and reusability. The immobilized enzyme retained 85% of its initial activity after 7 days of storage at room temperature, compared to 55% for the free enzyme. Reusability tests demonstrated that immobilized LpAAL protein maintained approximately 50% of its activity after six consecutive reaction cycles, highlighting its robustness over repeated use. These results underscore the advantages of nanofiber-based immobilization in enhancing enzyme stability and utility for industrial applications, offering a practical approach to overcoming the limitations associated with free enzyme systems.
Tuning the Compatibilizer Content and Healing Temperature in Thermally Mendable Polyamide 6/Cyclic Olefin Copolymer Blends
Authors: Perin Davide , Botta Luigi , Rigotti Daniele , Dorigato Andrea , Fredi Giulia , Pegoretti Alessandro
Published: January 2025

This study presents the formulation and comprehensive characterization of compatibilized polyamide 6 (PA6)/cyclic olefin copolymer (COC) blends with the aim of developing a self-healing matrix for thermoplastic structural composites. Rheological analysis highlighted the compatibilizing effect of ethylene glycidyl methacrylate (E-GMA), as evidenced by an increase in viscosity, melt strength (MS), and breaking stretching ratio (BSR), thus improving the processability during film extrusion. E-GMA also decreased COC domain size and improved the interfacial interaction with PA6, which was at the basis of a higher tensile strength and strain at break compared to neat PA6/COC blends. E-GMA also significantly boosted the healing efficiency (HE), measured via fracture toughness tests in quasi-static and impact conditions. The optimal healing temperature was identified as 160 °C, associated with an HE of 38% in quasi-static mode and 82% in impact mode for the PA6/COC blends with an E-GMA content of 5 wt% (PA6COC_5E-GMA). The higher healing efficiency under impact conditions was attributed to the planar fracture surface, which facilitated the flow of the healing agent in the crack zone, as proven by fractography analysis. This work demonstrates the potential of E-GMA in fine-tuning the thermomechanical properties of PA6/COC blends. PA6COC_5E-GMA emerged as the formulation with the best balance between processability and self-healing efficiency, paving the way for advanced multifunctional self-healing thermoplastic composites for structural applications.
Turbat al-Ḥusayn: Modern Presentation of an Early Shīʿī Practice
Authors: Gerami S. M. Hadi , Aghagolizadeh Zinab
Published: January 2025

This article explores the historical and contemporary evolution of turbat al-ḥusayn, the sacred soil of Karbala, as a central element in shaping Shīʿī identity and ritual practices. From the early Islamic centuries, turbat al-ḥusayn has served not only as a symbol of healing and blessing but also as a key component of Shīʿī collective memory. The paper examines the development of turbat rituals across three significant periods: pre-Safavid, post-Safavid, and post-revolutionary Iran. During the pre-Safavid period, including the medieval Islamic centuries, the sanctification of turbat evolved through the efforts of Shīʿī Imams such as al-Bāqir and al-Ṣādiq, who integrated it into the theological framework of wilāyah (guardianship) and Shīʿī ritual practices. This period also witnessed the gradual codification of its ritualistic and medicinal uses in foundational Shīʿī texts. During the Safavid era, turbat became institutionalized as a marker of Shīʿī identity, with its economic significance expanding through the production of prayer tablets and rosaries. Following the 1979 Islamic Revolution in Iran, turbat was reinterpreted as a symbol of martyrdom and resistance, aligning with revolutionary ideologies and narratives that paralleled the sacrifices of Karbala with contemporary struggles. The COVID-19 pandemic introduced new dimensions to turbat’s role, with its promotion as a medicinal remedy by religious figures, despite lacking historical precedent in traditional Shīʿī teachings. These developments illustrate how turbat al-ḥusayn continues to be dynamically recontextualized in response to modern challenges. The study concludes that turbat al-ḥusayn transcends its ritualistic and spiritual origins, serving as a flexible and enduring symbol of Shīʿī identity. Its evolving interpretations underscore the interplay between tradition and modernity, highlighting its ongoing relevance in both devotional life and socio-political discourse.
The Paradox of Religiosity–Secularism in Formal Religious Education
Authors: Karataş Meryem
Published: January 2025

Creating a conceptual unity is an important starting point for understanding a subject. It is more difficult to find a common definition if the concept in question is ‘religion, religiosity, secularism’, which can vary according to the field of the person making the definition, where he/she positions himself/herself in relation to religion, the characteristics of the religion he/she believes in (or does not believe in), and many other parameters. In order to draw the boundaries of this research correctly, it is necessary to clarify the development and changes in the concept of ‘religion’ and the related concepts of ‘religiosity and secularism’ in the historical process. Among the places where the effectiveness of these concepts at the theoretical level can be examined are the textbooks taught in Anatolian Imam Hatip High Schools. The nature or content of the fiqh textbooks taught in Imam Hatip High Schools, which can be exemplified as an educational institution of religious culture reinforcement in Turkey, is within the scope of this study. In connection with this subject, the aim of this study is to analyse the fiqh and fiqh reading textbooks taught in Anatolian Imam Hatip High Schools from the perspective of religiosity and secularism. Fiqh, from the perspective of Islamic theology, contains normative principles that govern personal and social practices. As textbooks, fiqh and fiqh readings were chosen because they are likely to provide data on the subject. This research employs a qualitative approach, utilising document analysis as its primary method to investigate these textbooks. The analysis is based on textbooks that were approved by the Ministry of National Education and taught during the 2023–2024 academic year. For the purposes of this study, only explicit verbal content was considered, while implicit messages were excluded. As a result of this study, it is understood that both books have a religiosity-centred perspective and that there are chapters in which changes are taken into consideration rather than secularism.
Design of a Novel Bio-Inspired Three Degrees of Freedom (3DOF) Spherical Robotic Manipulator and Its Application in Human–Robot Interactions
Authors: Soltanov Suleyman , Roberts Rodney
Published: January 2025

Studying the interactions between biological organisms and their environment provides engineers with valuable insights for developing complex mechanical systems and fostering the creation of novel technological innovations. In this study, we introduce a novel bio-inspired three degrees of freedom (DOF) spherical robotic manipulator (SRM), designed to emulate the biomechanical properties observed in nature. The design utilizes the transformation of spherical Complex Spatial Kinematic Pairs (CSKPs) to synthesize bio-inspired robotic manipulators. Additionally, the use of screw theory and the Levenberg–Marquardt algorithm for kinematic parameter computation supports further advancements in human–robot interactions and simplifies control processes. The platform directly transmits motion from the motors to replicate the ball-and-socket mobility of biological joints, minimizing mechanical losses, and optimizing energy efficiency for superior spatial mobility. The proposed 3DOF SRM provides advantages including an expanded workspace, enhanced dexterity, and a lightweight, compact design. Experimental validation, conducted through SolidWorks, MATLAB, Python, and Arduino, demonstrates the versatility and broad application potential of the novel bio-inspired 3DOF SRM, positioning it as a robust solution for a wide range of robotic applications.
Biomedical Signal Processing and Health Monitoring Based on Sensors
Authors: Choi Sang Ho , Yoon Heenam , Baek Hyun Jae , Long Xi
Published: January 2025

The healthcare industry is undergoing rapid transformation driven by advancements in Internet of Things (IoT) technologies, particularly in biomedical signal processing and health monitoring [...]
A Novel Ultra-High Voltage Direct Current Line Fault Diagnosis Method Based on Principal Component Analysis and Kernel Density Estimation
Authors: Zhang Haojie , Gong Qingwu
Published: January 2025

As renewable energy resources are increasingly deployed on a large scale in remote areas, their share within the power grid continues to expand, rendering direct current (DC) transmission essential to the stability and efficiency of power systems. However, existing transmission line protection principles are constrained by limited fault feature quantities and insufficient correlation exploration among features, leading to operational refusals under remote and high-resistance fault conditions. To address these limitations in traditional protection methods, this study proposes an innovative single-ended protection principle based on Principal Component Analysis (PCA) and Kernel Density Estimation (KDE). Initially, PCA is employed for multidimensional feature extraction from fault data, followed by KDE to construct a joint probability density function of the multidimensional fault features, allowing for fault type identification based on the joint probability density values of new samples. In comparison to conventional methods, the proposed approach effectively uncovers intrinsic correlations among multidimensional features, integrating them into a comprehensive feature set for fault diagnosis. Simulation results indicate that the method exhibits robustness across various transition resistances and fault distances, demonstrates insensitivity to sampling frequency, and achieves 100% accuracy in fault identification across sampling time windows of 0.5 ms, 1 ms, and 2 ms.
Application of Smart Insoles in Assessing Dynamic Stability in Patients with Chronic Ankle Instability: A Comparative Study
Authors: Kang Seonghyun , Kim Jaewook , Kim Yekwang , Moon Juhui , Kim Hak Jun , Kim Seung-Jong
Published: January 2025

Chronic ankle instability (CAI), due to its chronic nature and biomechanical complexity, is well-suited for continuous monitoring and tele-rehabilitation using wearable sensor technology. This study assessed whether a smart insole system, equipped with 4 force-sensing resistor sensors and an inertial measurement unit, combined with functional tests and biomechanical indices, could distinguish CAI patients from healthy controls. A total of 21 CAI patients (23.8 ± 5.1 years) and 16 controls (22.62 ± 2.60 years) completed a battery of functional performance tests while wearing the smart insole system. The results showed an increased medial-lateral pressure ratio in the CAI during heel raise (p = 0.031, effect size = 0.82) and hop tests, suggesting an everted foot position. Significant deviations in center-of-pressure trajectory during double-leg heel raises (p = 0.005, effect size = 1.10) suggested asymmetric motion coordination, while compensatory fluctuations of the lifted limb during single-leg balance tests (p = 0.011, effect size = 1.03) were greater in CAI patients. These findings facilitated the development of features to characterize CAI-specific movement patterns. Together, this system shows promise as a quantitative assessment tool for CAI, supporting improved treatment outcomes through tele-rehabilitation.
Repackaging and Performance Analysis of Implantable Pressure Sensor
Authors: Cui Liu , Wang Shuangkui , Zhao Kai , Si Zhisen
Published: January 2025

In recent years, repackaging technology has been widely used in miniaturized implantable pressure sensors. However, the current packaging structure still has significant problems regarding biocompatibility, environmental adaptability, and measurement accuracy, which greatly limits its application in vivo measurement systems. In this paper, we report a method for implantable pressure sensor repackaging based on silicone oil, polydimethylsiloxane (PDMS) film, and polymer (parylene) coating. A systematic investigation using finite element analysis is conducted to assess the impact of packaging components on sensor performance, providing a solid theoretical foundation for packaging optimization. Experimental results demonstrate that when the parylene coating thickness is below 30 µm, the sensors exhibit superior linearity, repeatability, and reliability, along with exceptional stability and dynamic response across clinically relevant pressure ranges. This research provides valuable insights into the packaging design of implantable pressure sensors, facilitating the development of more stable, reliable, and cost-effective sensors for in vivo measurement systems.
Sustainable Development of Traditional Business Culture: Merchant Guild Culture and Enterprise Innovation
Authors: Ren Li , Cheng Yanping
Published: January 2025

By exploring the positive elements of traditional business culture and combining them with modern enterprise management concepts, this paper aims to realize the sustainable development of enterprises and cultural heritage and innovation. In this context, this study empirically examines the impact and mechanisms of merchant guild culture (MGC) on corporate innovation, using A-share listed companies from 2010 to 2022 as a sample. The findings indicate that MGC positively influences contemporary corporate innovation through both external and internal channels. External channels include alleviating financing constraints and enhancing ESG performance, and internal influence channels such as improving integrity and emphasizing human capital. Additionally, social networks strengthen the relationship between MGC and corporate innovation. Furthermore, using the legal environment as a moderating variable has led to the discovery of a certain substitution relationship between formal and informal institutions. A heterogeneity analysis further shows that the effect of MGC on innovation is more pronounced in enterprises with low-risk preference and a foreign cultural impact.
The Directions of Spatial Development of Metropolitan Areas in Poland Based on the Automated Typology of the MA Localities as a Sustainable Solution to the Urban Sprawl Issue
Authors: Porczek Mariusz , Werner Piotr A.
Published: January 2025

Urban settlements in Poland have developed over time, leading to problems such as overpopulation and spatial expansion, which threaten the environment and create spatial chaos. Changes in the demographic structure in Poland led to the need for systematized settlement development. Since 1989, Polish urban areas have undergone significant metamorphosis, with some becoming depopulated and others becoming metropolitan areas. The high autonomy of municipalities allowed for uncontrolled growth of the settlement network, also in typically rural directions. The 2006 Act mandated regional development strategies and urban spatial development plans for voivodship self-governments, but this has not produced adequate results. Cities continue to grow, often causing problems for society, local authorities, and natural ecosystems. This study examined the potential for urban settlement development using k-means cluster analysis to calculate the buildable area, taking in the detail of three case studies: Warsaw, Lodz, and Olsztyn. This allowed the classification of towns into zones corresponding to their level of urbanization. The k-means method used in the study gave similar and even more efficient results than the manual classification. This may contribute to stopping the growing urban expansion into rural areas inadequately prepared for the change in urban structure. This research can help to maintain sustainability and compensate for the problems of pollution in urban and rural areas.
Leveraging City Cameras for Human Behavior Analysis in Urban Parks: A Smart City Perspective
Authors: Gravitz-Sela Shir , Shach-Pinsly Dalit , Bryt Ori , Plaut Pnina
Published: January 2025

Urban parks enhance urban life by providing essential spaces for recreation, relaxation, and social interaction. However, there is a lack of understanding of how park settings influence usage patterns by socio-demographic characteristics. This study seeks to address this gap by exploring the association between park characteristics and gendered usage patterns across different times of the day. We employed big data analytics and computer vision techniques to analyze human behavior in two urban parks. These parks have comparable environments characterized by shared features, including paths, playgrounds, seating, lawns, greenery, and amenities. One is designed as a linear park, while the other is trapezoid-shaped. The distribution of facilities varies within the parks’ spaces. The key innovation of this approach lies in the use of computer vision for spatial analysis based on user-specific characteristics, particularly gender. City surveillance cameras are leveraged to gather extensive data on park usage. A comparative evaluation of the two urban parks includes a detailed examination of temporal and spatial usage patterns, offering new insights into the dynamics of urban park utilization. Findings reveal specific park features, such as playgrounds and paths, showed varying levels of utilization by different genders, highlighting the importance of tailored urban design. Males favored open lawns with dog facilities, whereas females preferred areas near playgrounds. The application of smart city technologies, such as city cameras, sets the stage for future directions in urban planning and design, highlighting opportunities to integrate advanced analytics into planning practices.
A Rule-Based Modular Energy Management System for AC/DC Hybrid Microgrids
Authors: Hussain Akhtar , Kim Hak-Man
Published: January 2025

Microgrids are considered a practical solution to revolutionize power systems due to their ability to island and sustain the penetration of renewables. Most existing studies have focused on the optimal management of microgrids with a fixed configuration. This restricts the application of developed algorithms to other configurations without major modifications. The objective of this study is to design a rule-based modular energy management system (EMS) for microgrids that can dynamically adapt to the microgrid configuration. To realize this framework, first, each component is modeled as a separate entity with its constraints and bounds for variables. A wide range of components such as battery energy storage systems (BESSs), electric vehicles (EVs), solar photovoltaic (PV), microturbines (MTs), and different priority loads are modeled as modules. Then, a rule-based system is designed to analyze the impact of the presence/absence of one module on the others and update constraints. For example, load shedding and PV curtailment can be permitted if the grid module is not included. The constraints of microgrid components present in any given configuration are communicated to the EMS, and it optimizes the operation of the available components. The configuration of microgrids could be as simple as flexible loads operating in grid-connected mode or as complex as a hybrid microgrid with AC and DC buses with a diverse range of equipment on each side. To facilitate the realization of diverse configurations, a hybrid AC/DC microgrid is considered where the utility grid and interlinking converter (ILC) are also modeled as separate modules. The proposed method is used to test performance in both grid-connected and islanded modes by simulating four typical configurations in each case. Simulation results have shown that the proposed rule-based modular method can optimize the operation of a wide range of microgrid configurations.
Environmental Stewardship Education in Tuvalu, Part 1: The Role of Policy Alignment
Authors: Tinilau Soseala S. , Hemstock Sarah L. , Mercer Theresa G. , Hannaford Matthew , Kythreotis Andrew P.
Published: January 2025

Environmental stewardship is crucial for fostering sustainable development, particularly in vulnerable small-island developing states like Tuvalu. Government policies and frameworks play a vital role in shaping the education system, but inconsistencies in policy alignment often hamper efforts to embed Environmental Stewardship Education (ESE) into the national curriculum. We aimed to answer four questions: 1. What formal policies shape Environmental Stewardship Education (ESE) in Tuvalu? 2. Are national educational and environmental policies mutually consistent? 3. Are these national policies consistent with regional and global policies? 4. What challenges hinder the implementation of ESE in Tuvalu? These questions were addressed using a study of regional, international, and Tuvaluan online-available documentary assessments of national policies and frameworks in conjunction with those obtained from the Education Department. Our findings revealed that a combination of Tuvalu’s environmental and educational policies was instrumental in shaping ESE. Nationally, educational and environmental policies are internally inconsistent, as well as being inconsistent externally with regional and international policies. Recommendations for improving policy alignment and the sustainable integration of ESE into the curriculum are provided. The second part (Part 2) of our review covers the development and delivery of effective curricula for ESE.
In-Depth Analysis of Fatal Motorcycle Accidents—Case Study in Slovenia
Authors: Tollazzi Tomaž , Parežnik Laura Brigita , Gruden Chiara , Renčelj Marko
Published: January 2025

Motorcyclists remain a disproportionately large group of vulnerable road users, with fatality rates significantly higher than that in other road groups. Additionally, fatal accidents involving motorcyclists have a more slowly decreasing trend in comparison to that of other road users, while the number of this kind of users is growing fast. For all these reasons, there is a need to understand what the key factors leading to fatal accidents are in order to identify the possible measures to minimize the accidents themselves or at least their consequences. This would permit, indeed, to positively impact the road traffic system, leading to the creation of the safest road traffic system possible, as it is the goal of the Sustainable Safety approach. The aim of this study is to dive into the mentioned problem, analyzing fatal motorcycle accidents in Slovenia over a decade, highlighting the key factors contributing to these incidents. By integrating data from four databases, the study evaluated accident trends, infrastructural elements, and rider behavior through a multi-stage analysis. Firstly, data were collected from four national, up-to-date databases that contain information about road accidents themselves, the road infrastructure, additional police data, and media descriptions. After merging this information into one comprehensive database, where each row represents all the data available for one accident, a general analysis of accidents’ trends over the considered 10-year period was developed, considering at first all fatal road accidents, then deepening it to accidents caused by a motorcyclist, and finally to single-vehicle accidents. A statistical analysis followed, aimed at identifying a statistical correlation between the accidents and the factors leading to them. The results of the first accident analysis indicated that excessive speed, incorrect driving direction, and overtaking maneuvers are the primary causes of fatal accidents, especially on non-urban roads preferred by motorcyclists. Single-vehicle accidents frequently involve collisions with roadside objects, including safety barriers and poles, underscoring the need for targeted infrastructural improvements. The following correlation analysis revealed that a total of seven factors were statistically significant: three human factors (age, gender, experience)—which were the ones with the strongest correlations—one infrastructural factor (pavement width), and three factors belonging to external conditions (accident type, cause, and location). Of these, four were positively correlated to the causer, while three, i.e., pavement width, causes, and road location, were negatively correlated. This study provides a foundation for future research on less severe accidents and proactive risk behavior analysis, aiming to improve motorcyclist safety comprehensively.
The Sustainable Fashion Value Proposition of Companies Identifying with the Zero Waste Movement
Authors: Zdonek Iwona , Podgórska Marzena , Hysa Beata
Published: January 2025

Characterized by inexpensive and readily available products, fast fashion has increased the consumption and disposal of clothing, for which criticism has been significant due to its negative environmental and social impact. Therefore, transitioning to sustainable business models (SBMs) that balance profit with corporate social responsibility (CSR) is critical. This study explores sustainable value propositions in Polish Zero Waste fashion businesses, addressing the gap in research on SBMs. It also employs the theory of organizational paradoxes to examine tensions between profit maximization and CSR. Data were collected from 249 Polish Zero Waste companies listed on mapazerowaste.pl and analyzed through content analysis and statistical methods. Additionally, 21 YouTube videos from 2020 to 2022 were examined to study sustainable fashion promotion. Multiple coding and categorization schemes were used to identify themes, followed by frequency analysis and correspondence analysis. Second-hand clothing emerged as the most common value proposition (120 companies), reflecting consumer trends in resale. The repair sector with cobbler and leather repair services (55 companies) also showed a strong presence, highlighting demand for tailoring and upcycling services Rental services (2 companies) remain niche due to limited consumer acceptance. Promotion efforts on YouTube focus on building awareness of fast fashion’s impacts and teaching sustainable behaviors. Sustainable value propositions, exemplified by Polish Zero Waste businesses, synthesize profit and CSR strategies, addressing organizational paradoxes. These findings inform strategies to balance financial and socio-environmental goals, with implications for policy and practice in advancing sustainable fashion.
Association of GSTM1 and GSTT1 Copy Number Variation with Chromosomal Aberrations in Nuclear Power Plant Workers Exposed to Occupational Ionizing Radiation
Authors: Lee Joong won , Lee Younghyun , Kim Yang Jee
Published: January 2025

Exposure to low-dose ionizing radiation in occupational settings raises concerns about chromosomal aberrations (CAs) and their potential impact on genomic stability. Copy number variations (CNVs), structural genomic changes, influence susceptibility to environmental stressors and radiation-induced damage. This study analyzed CAs in 180 nuclear power plant workers exposed to occupational radiation and 45 controls, stratified by GSTM1 and GSTT1 CNVs. Workers exhibited significantly higher frequencies of chromatid-type and chromosome-type aberrations, of 5.47 and 3.01 per 500 cells, respectively, compared to 3.57 and 0.64 in controls (p < 0.001 for both). In the relatively high-exposure group, chromatid-type aberrations decreased with increasing GSTM1 and GSTT1 copy numbers. For GSTM1, individuals with zero copies showed 6.37 ± 3.47 aberrations per 500 cells, compared to 5.02 ± 3.05 for one copy and 4.67 ± 2.40 for two or more copies (p = 0.06). A similar trend was observed for GSTT1, with 6.00 ± 3.29 aberrations per 500 cells for zero copies, 5.38 ± 2.79 for one copy, and 4.11 ± 4.26 for two or more copies (p = 0.05). Poisson regression analysis further supported these findings after adjusting for potential confounders such as age, smoking status, and alcohol intake. Workers with null genotypes exhibited a 1.36-fold increase in chromatid-type aberrations compared to those with higher copy numbers under relatively high-exposure conditions, suggesting a synergy effect between GSTM1 and GSTT1 null genotypes in modulating radiation-induced aberrations. These findings underscore the role of genetic susceptibility, particularly involving GSTM1 and GSTT1 CNVs, in modulating radiation-induced chromosomal damage. The observed gene–environment interaction in the relatively high-exposure group suggests that pre-existing CNVs contribute to chromosomal instability under radiation exposure.