bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Mixed Na2O/K2O on Chemical Durability and Spectral Properties of P2O5-Al2O3-BaO-K2O-Na2O-Nd2O3 Phosphate Glasses
Authors: Ma Xiben , Xu Yongchun , Cheng Jimeng , Sun Shiyu , Chen Youkuo , Wang Xin , Chen Wei , Chen Shubin , Hu Lili
Published: October 2022

A series of 56P2O5-7.5Al2O3-5.9BaO-(28.56-x)K2O-xNa2O-1.51Nd2O3 phosphate glasses with different Na/(Na+K) ratios, which were specially designed for high-power laser application, were prepared by a high-temperature melting method. Except for the density, refractive index, glass transition temperature, and DC conductivity, the chemical durability and spectral properties, as emphasized by high-power and high-energy laser material, were further measured and analyzed. Regarding the chemical durability, the dissolution rates of these glasses do not show an evident mixed alkali effect with increasing the Na/(Na+K) ratio, although the effect is obvious for the glass transition temperature and DC conductivity. To better understand the nature of the dissolution mechanism, the ionic release concentrations of every element are determined. Both Na and K undergo ion exchange, but the ion exchange rate of K is much larger than that of Na. In terms of the spectral properties, the J–O parameters, emission cross-section, radiation lifetime, fluorescence lifetime, effective bandwidth, fluorescence branching ratio, and quantum efficiency are determined from absorption and emission spectra. The trend of Ω2 deviating from linearity indicates that the coordination environment symmetry of Nd3+ ions and the covalence of Nd-O also present an evident mixed alkali effect. The most important finding is that the emission cross-section and fluorescence lifetime of Nd3+ ions at 1053 nm were not affected by the change in the Na/K ratio. According to the above experimental results, the optimized value of the Na/K ratio was determined, based on which the 56P2O5-7.5Al2O3-5.9BaO-(28.56-x)K2O-xNa2O-1.51Nd2O3 glass maintains a high emission cross-section with good chemical durability.
Porous Co-Pt Nanoalloys for Production of Carbon Nanofibers and Composites
Authors: Afonnikova Sofya D. , Popov Anton A. , Bauman Yury I. , Plyusnin Pavel E. , Mishakov Ilya V. , Trenikhin Mikhail V. , Shubin Yury V. , Vedyagin Aleksey A. , Korenev Sergey V.
Published: October 2022

The controllable synthesis of carbon nanofibers (CNF) and composites based on CNF (Metals/CNF) is of particular interest. In the present work, the samples of CNF were produced via ethylene decomposition over Co-Pt (0–100 at.% Pt) microdispersed alloys prepared by a reductive thermolysis of multicomponent precursors. XRD analysis showed that the crystal structure of alloys in the composition range of 5–35 at.% Pt corresponds to a fcc lattice based on cobalt (Fm-3m), while the CoPt (50 at.% Pt) and CoPt3 (75 at.% Pt) samples are intermetallics with the structure P4/mmm and Pm-3m, respectively. The microstructure of the alloys is represented by agglomerates of polycrystalline particles (50–150 nm) interconnected by the filaments. The impact of Pt content in the Co1−xPtx samples on their activity in CNF production was revealed. The interaction of alloys with ethylene is accompanied by the generation of active particles on which the growth of nanofibers occurs. Plane Co showed low productivity (~5.5 g/gcat), while Pt itself exhibited no activity at all. The addition of 15–25 at.% Pt to cobalt catalyst leads to an increase in activity by 3–5 times. The maximum yield of CNF reached 40 g/gcat for Co0.75Pt0.25 sample. The local composition of the active alloyed particles and the structural features of CNF were explored.
Review with Analytical-Numerical Comparison of Contact Force Models for Slotted Joints in Machines
Authors: Autiero Matteo , Cera Mattia , Cirelli Marco , Pennestrì Ettore , Valentini Pier Paolo
Published: October 2022

The pin-in-the-slot joint is a common element in machines, and the dynamics of joints with clearances is an actively investigated topic. Important applications of such a joint can be found in Geneva mechanisms, robotized gear selectors, centrifugal vibration absorbers (CPVA) and other important mechanical devices. The paper will review the main analytical steps required to obtain the equations characterizing the different force contact models. Furthermore, a numerical test bench where such models are introduced for modeling the clearances between the pin and slot is proposed. In this regard, the present study will offer a comparison and discussion of the numerical results obtained with the different force contact models herein reviewed.
Optimal Design of a Five-Bar Planar Manipulator and Its Controller by Using Different Algorithms for Minimum Shaking Forces and Moments for the Largest Trajectory in a Usable Workspace
Authors: Kavala Sen Deniz , Yildiz Ahmet , Kopmaz Osman
Published: October 2022

In this paper, a structural design and controller optimization process for a five-bar planar manipulator are studied using three different population-based optimization techniques: particle swarm optimization, genetic algorithm, and differential evolution. First, the desired kinematic properties of the manipulator, such as the position, velocity, and acceleration of the endpoint, are determined using inverse kinematics. Then, an optimization problem is created to minimize the shaking force and moments, and the desired kinematic quantities are implemented as constraints. All the link properties of the manipulator are defined as design variables, and the optimization results are obtained. The results show that it is possible to significantly reduce the shaking force and moment significantly thanks to the optimal design parameters. Finally, the controller is optimized to find the best PID gains considering the forward kinematics of the manipulator. It is observed that the shaking force and shaking moment can be reduced by 99% and 54%, respectively, which has a very positive effect on the accuracy of the trajectory tracking. Moreover, the performances of the optimization methods are compared by using the same number of iterations in the calculations, and thus, it can be seen that the GA method achieves the best results compared to the others. Therefore, the results of this study are of utmost importance for a manufacturer, who wants to design a five-bar planar manipulator and its controller.
Martensitic Transformation, Magnetic and Mechanical Characteristics in Unidirectional Ni–Mn–Sn Heusler Alloy
Authors: Sun Haodong , Jing Chao , Zeng Hui , Su Yuan , Yang Siyuan , Zhang Yuanlei , Bachagha Tarek , Zhou Ting , Hou Long , Ren Wei
Published: October 2022

A textured structure of Ni–Mn–Sn Heusler alloy with [001] preferred orientation has been grown by the directional solidification method. The crystal exhibits a single austenite phase L21 cubic structure (a = 5.997 Å) at room temperature. Magnetization and electronic transport measurements reveal the phase transformation characteristics. The maximum values of magnetic entropy change determined by Maxwell’s thermodynamic relation during the structural and magnetic phase transformations are 3.5 J/kg·K and −4.1 J/kg·K, and the total effective refrigerant capacity reaches about 314 J/kg (5 T). The evident reduction in hysteresis loss and broad operating temperature window provide a greater prospect for improving the cyclic stability of refrigeration and optimizing the application of such a magnetic refrigeration material. Both magnetoresistance (−18%, 5 T) and exchange bias field (302 Oe, 2 K) have also been investigated to understand the nature of phase transformations and exchange interactions. Furthermore, as the material exhibits excellent mechanical properties (1068 MPa, 9.0%), our experimental results provide a new reference for the application of Ni–Mn–Sn Heusler alloys.
Synthesis of a Doped α-Fe2O3/g-C3N4 Catalyst for High-Efficiency Degradation of Diazinon Contaminant from Liquid Wastes
Authors: Al-Musawi Tariq J. , Asgariyan Rasoul , Yilmaz Murat , Mengelizadeh Nezamaddin , Asghari Abolfazl , Balarak Davoud , Darvishmotevall Mohammad
Published: October 2022

In this work, a hematite/porous graphite carbon-nitride (α-Fe2O3/g-C3N4) catalyst was synthesized through the doping of hematite loaded onto porous graphite carbon-nitride using a heat treatment process. Then, the ability of catalyst was evaluated to degrade diazinon (DZN) for the first time, mainly via the sonophotocatalytic process. Among the samples, the greatest DZN degradation was observed in the sonophotocatalytic system, which separated 100% of DZN from the aqueous solution after 50 min, while the removal percentages for the sonocatalytic, photocatalytic, and adsorption systems were 72.9, 89.1, and 58.1%, respectively. The results of scavengers showed that both sulfate and hydroxyl radicals (•OH) participated in removing DZN, although positive holes and negative •OH played a major role. Moreover, the removal efficiencies of the target pollutant using the sonophotocatalytic process were higher than those using the photocatalytic, sonocatalytic, and adsorption processes. The reaction profile followed pseudo-first-order kinetics, and the reaction rate coefficient for the sonophotocatalytic system was 2.2 times higher than that of the photocatalytic system and 2.64 times higher than that of the sonocatalytic system. The energy consumption of the sonophotocatalytic system after 60 min was 11.6 kWh/m3, while it was 31.1 kWh/m3 for the photocatalytic system. A DZN removal percentage of 100% was obtained after 50 min under the following conditions: UV intensity of 36 watts, ultrasound frequency of 36 kHz, DZN concentration of 50 mg/L at pH 5, and α-Fe2O3/g-C3N4 dosage of 0.4 g/L. The catalyst reusability was examined with only a 9.9% reduction in efficiency after eight consecutive cycles. The chemical oxygen demand (COD) and total organic compound (TOC) removal percentages were 95.6% and 88.6%, respectively, and the five-day biochemical oxygen demand (BOD5)/COD ratio was 0.16 at the beginning of the degradation process and 0.69 at the end of the process. In addition, toxicological experiments showed that degradation of DZN by the sonophotocatalytic process exhibited low toxicity. All results confirmed that the sonophotocatalytic process using α-Fe2O3/g-C3N4 was a highly efficient process for DZN pollutant removal from liquid wastes.
Fuzziness, Indeterminacy and Soft Sets: Frontiers and Perspectives
Authors: Voskoglou Michael Gr.
Published: October 2022

The present paper comes across the main steps that were laid from Zadeh’s fuzziness and Atanassov’s intuitionistic fuzzy sets to Smarandache’s indeterminacy and to Molodstov’s soft sets. Two hybrid methods for assessment and decision making, respectively, under fuzzy conditions are also presented using suitable examples that use soft sets and real intervals as tools. The decision making method improves on an earlier method of Maji et al. Further, it is described how the concept of topological space, the most general category of mathematical spaces, can be extended to fuzzy structures and how to generalize the fundamental mathematical concepts of limit, continuity compactness and Hausdorff space within such kinds of structures. In particular, fuzzy and soft topological spaces are defined and examples are given to illustrate these generalizations.
Synchronization of Fractional-Order Neural Networks with Time Delays and Reaction-Diffusion Terms via Pinning Control
Authors: Hymavathi M. , Ibrahim Tarek F. , Ali M. Syed , Stamov Gani , Stamova Ivanka , Younis B. A. , Osman Khalid I.
Published: October 2022

This paper introduces a novel synchronization scheme for fractional-order neural networks with time delays and reaction-diffusion terms via pinning control. We consider Caputo fractional derivatives, constant delays and distributed delays in our model. Based on the stability behavior, fractional inequalities and Lyapunov-type functions, several criteria are derived, which ensure the achievement of a synchronization for the drive-response systems. The obtained criteria are easy to test and are in the format of inequalities between the system parameters. Finally, numerical examples are presented to illustrate the results. The obtained criteria in this paper consider the effect of time delays as well as the reaction-diffusion terms, which generalize and improve some existing results.
An Estimated Analysis of Willingness to Wait Time to Pay Rice Agricultural Insurance Premiums Using Cox’s Proportional Hazards Model
Authors: Hidayat Yuyun , Sukono  , Subartini Betty , Khairunnisa Nida , Sambas Aceng , Purwandari Titi
Published: October 2022

In this paper, we determined the factors that affect the waiting time of rice farmers’ willingness to pay the premium for the Rice Farming Insurance Program (RFIP) using survival analysis. The survival analysis method was carried out using the Cox proportional hazard model with the Efron approach. The case study in this research is rice farmers in Cibungur Village, Parungponteng District, Tasikmalaya Regency. The results of the analysis show that the predictor variables that are significant to the waiting time of rice farmers’ willingness to pay the insurance premium for RFIP are their last education, other occupations, rice production, and farming costs. The results of the research are expected to produce additional information for the government and implementers of rice farming insurance regarding the condition of farmers in the field, so that it can be improved in the future.
Analytical Solution for Controlled Drug Release with Time-Dependent Diffusion Parameter
Authors: Mohd Mahali Shalela , Setapa Amanina , Harun Fatimah Noor , Wang Song
Published: October 2022

Drugs seem to diffuse in different manners in a delivery device due to the increment of the device pore size during swelling. However, the diffusion parameter, D, is often assumed constant. In this work, a new developed controlled drug release model with a time-dependent diffusion parameter is compared to one- and two-phase models. The new model was obtained as an improvement of the previous constant and piece-wise constants models. The models are developed by solving an advection–diffusion equation using the Landau transformation method and the separation of variables method. To test these models, we fit experimental data by the developed models using the least squares fitting technique. The curve-fitting result shows that the least squares error of the two-phase and the time-dependent models are 10 times smaller than the single-phase model. The CPU time for the time-dependent model is the lowest, showing that a time-dependent model is the best option among all three tested models considering both factors of the determined least squares error and the time consumption.
Efficacy and Safety of Neoadjuvant Chemotherapy Combined with Adjuvant Chemotherapy for Locally Advanced Colon Cancer: A Propensity Score-Matching Analysis
Authors: Zeng Wei , Liu Yi , Wang Chuandong , Yang Changshun , Lin Shengtao , Li Weihua
Published: October 2022

Background and Objectives: Increasing evidence supports the use of neoadjuvant chemotherapy (NAC) for locally advanced colon cancer (LACC). However, its effectiveness remains controversial. This study explored the safety and efficacy of NAC combined with laparoscopic radical colorectal cancer surgery and adjuvant chemotherapy (AC) for LACC. Materials and Methods: We retrospectively analyzed 444 patients diagnosed with LACC (cT4 or cT3, with ≥5 mm invasion beyond the muscularis propria) in our hospital between 2012 and 2015. Propensity score matching (PSM; 1:2) was performed to compare patients treated with NAC and those treated with adjuvant chemotherapy (AC). Results: Overall, 42 patients treated with NAC were compared with 402 patients who received only AC. After PSM, 42 patients in the NAC group were compared with 84 patients in the control group, with no significant differences in the baseline characteristics between groups. The pathological tumor sizes in the NAC group were significantly smaller than those in the AC group (3.1 ± 2.1 cm vs. 5.8 ± 2.5 cm). Patients in the NAC group had a significantly lower T stage than those in the AC group (p < 0.001). After neoadjuvant chemotherapy, a significant response was observed in four (9.6%) patients, with two (4.8%) showing a complete response. The 5-year overall survival rates (88.1% vs. 77.8%, p = 0.206) and 5-year disease-free survival rates (75.1% vs. 64.2%, p = 0.111) did not differ between the groups. However, the 5-year cumulative rate of distant recurrence was significantly lower in the NAC than in the AC group (9.6% vs. 29.9%, p = 0.022). Conclusions: NAC, combined with AC, could downstage primary tumors of LACC and seems safe and acceptable for patients with LACC, with a similar long-term survival between the two treatments.
Surgical Effect Observation and Treatment Strategy Analysis of Pseudo Urgency Syndrome
Authors: Gao Zhenhua , Lin Han , Ke Kunbin , Yao Tingqiang , Zhang Quan , Li Ling , Wang Xingqi , Shen Jihong
Published: October 2022

Background and Objectives: pseudo urgency syndrome among patients with mixed incontinence (MUI) causes and the corresponding treatment strategies is explored. Materials and Methods: A total of 40 patients with MUI are treated with transobturator tape (TOT) and/or solifenacin succinate. Further, 30 patients with simple stress urinary incontinence (SUI) that were treated with transobturator tape (TOT) from the period of December 2018 to August 2020 are retrospectively analyzed; then, their clinical characteristics and therapeutic effects were summarized and analyzed. Results: The effective rates of SUI symptoms in MUI and simple SUI groups were 85% and 90%, respectively; further, the difference was noted as not statistically significant (P > 0.05). Among the 40 patients with MUI, 12 patients had unstable bladder contraction, and the other 28 patients showed normal bladder compliance. The treatment effectiveness rates of SUI symptoms in patients with unstable bladder contraction and normal bladder compliance were 83.3% and 85.7%, respectively; further, no significant difference was noted (P > 0.05). However, the effective rates of urge urinary incontinence (UUI) were 50% and 85.7%, respectively, however the difference was noted as statistically significant (P < 0.05). Conclusions: Most of the UUI symptoms in MUI patients may be “pseudo urgency syndrome” caused by the worry about the leakage of urine, rather than a real sense of UUI that is caused by excessive bladder excitement. Direct surgical treatment in patients with MUI can improve the symptoms of urinary incontinence, and the effect is more obvious in patients with urinary frequency who have normal bladder compliance according to urodynamics.
Surveillance versus Adjuvant Treatment with Chemotherapy or Radiotherapy for Stage I Seminoma: A Systematic Review and Meta-Analysis According to EAU COVID-19 Recommendations
Authors: Kang Dong Hyuk , Cho Kang Su , Jeong Jae Yong , Moon Young Joon , Chung Doo Yong , Jung Hae Do , Lee Joo Yong
Published: October 2022

Background and Objectives: During the coronavirus disease 2019 (COVID-19) outbreak, the European Association of Urology (EAU) Guidelines Office Rapid Reaction Group (GORRG) recommended that patients with clinical stage I (CSI) seminoma be offered active surveillance (AS). This meta-analysis aimed to evaluate the efficacy of AS versus adjuvant treatment with chemotherapy or radiotherapy for improving the overall survival (OS) of CSI seminoma patients. Materials and Methods: A systematic review was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The PubMed/Medline, EMBASE, and Cochrane Library databases were searched. The primary outcome was 5-year OS, and the secondary outcome was the 5-year relapse-free survival (RFS). The outcomes were analyzed as odds ratios (ORs) and 95% confidence intervals (CIs). Results: A total of 14 studies were included. Overall, the quality scores were relatively high, and little publication bias was noted. In terms of the 5-year OS, 7 studies were analyzed; there was no significant difference between AS and adjuvant treatment (OR, 0.99; 95% CI, 0.41–2.39; p = 0.97). In terms of 5-year RFS, 12 studies were analyzed. Adjuvant treatment reduced the risk of 5-year recurrence by 85% compared with AS (OR, 0.15; 95% CI, 0.08–0.26; p < 0.001). Conclusions: In terms of the OS in CSI seminoma patients, no intergroup difference was noted, so it is reasonable to offer AS, as recommended by the EAU GORRG until the end of the COVID-19 pandemic. However, since there is a large intergroup difference in the recurrence rate, further research on the long-term (>5 years) outcomes is warranted.
Deep Vein Thrombosis of the Left Lower Limb in a Sudanese Child with Sickle Cell Disease
Authors: Mustafa Alam Eldin Musa , Tahir Niemat Mohammed , Ahmed Mohamed Nur Allah Elnaji , Mohammed Adil Abdullah , Mohammed Sara Ismail
Published: October 2022

This is a case of an eleven-year-old female Sudanese child, a known Sickle Cell Anemia (SCA) patient, who presented with fever, as well as left thigh and leg swelling that was associated with pain and warmness, which was diagnosed as Deep Vein Thrombosis (DVT) of her left lower limb. She had a previous history of admissions to the emergency room, during which she once received blood. The patient was managed by carrying out a basic routine initial laboratory investigation. A Doppler ultrasound scan showed features consistent with DVT. Based on the clinical findings and investigation results, management began by providing the patient with intravenous fluid, analgesia, packed Red Blood Cells (RBCs), intravenous antibiotics, and low-molecular-weight heparin. Further consultations showed that there was no need for vascular surgery or surgical intervention. This case highlights the need for more studies on DVT and Venous Thromboembolism (VTE) complications in children with SCA, so as to develop strategies for diagnosis and management in order to reduce the risk of life-threatening complications of VTE in patients with Sickle Cell Disease SCD.
Mental Health of Nurses Working in a Judicial Psychiatry Hospital during the COVID-19 Pandemic in Italy: An Online Survey
Authors: La Rosa Gianluca , Maggio Maria Grazia , Cannavò Antonino , Tripoli Daniele , Di Mauro Federico , Casella Carmela , Rao Giuseppe , Manuli Alfredo , Calabrò Rocco Salvatore
Published: October 2022

The onset of this new pandemic has highlighted the numerous critical issues at the organizational level, which involve both national healthcare and the judicial system. For this reason, nurses working in prisons may exhibit a poor quality of life, mainly related to their high level of work stress. This cross-sectional survey aimed to assess the emotional state of nurses working in the Judicial Psychiatry Hospital of Barcellona PG (Messina, Italy) during the COVID-19 pandemic. Data collection occurred twice: from 1 April to 20 May 2020 (i.e., during the Italian lockdown) and from 15 October to 31 December 2021 (during the second wave). At baseline, the 35 enrolled nurses presented medium to high levels of stress. At T1, they had a reduction in perceived personal achievement (MBI-PR p = 0.01), an increase in emotional exhaustion (MBI-EE p < 0.001), and stress (PSS p = 0.03), as well as anxiety (STAI Y1/Y2 p < 0.001). Most participants underlined the high usability of the online system (SUS: 69.50/SD 19.9). We also found increased stress, anxiety, and burnout risk in nursing staff. The study clearly demonstrates that the first year of the COVID-19 pandemic in Italy caused a worsening of mental health among nurses working in prisons. We believe that monitoring the mental state of healthcare professionals is fundamental to improving their quality of life and healthcare services.
Increased Tropism of Extracellular Vesicles Derived from Palmitic Acid-Treated Hepatocytes to Activated Hepatic Stellate Cells
Authors: Yamaguchi Momoka , Kanazawa Takanori , Morino Sumire , Iioka Shingo , Watanabe Yuta , Dohi Naoki , Higashi Kenjirou , Kondo Hiromu , Ishikawa Tomohisa
Published: October 2022

Myofibroblast-like activated hepatic stellate cells (aHSCs), which produce collagen, a major cause of liver fibrosis, are specific target cells for antifibrotic treatment. Recently, several reports have indicated that extracellular vesicles (EVs) play important roles in cell-to-cell communication through their tropism for specific cells or organs. Therefore, the present study aimed to identify aHSC-directed EVs by focusing on cell-to-cell interactions in the liver under pathological conditions. EVs were derived from the hepatocyte cell line AML12 treated with or without palmitic acid (PA) and evaluated for their physical properties and uptake by the aHSC cell line LX-2. AML12-derived EVs had a mean particle diameter of 110–130 nm, negative charge, and expressed the exosomal makers CD9 and CD63. PA-treated AML12 cells released larger EVs with higher protein levels than those without PA treatment. The intracellular uptake efficacy of EVs derived from PA-treated AML12 cells into activated LX-2 cells was significantly higher than those without PA treatment. Our study revealed that PA treatment induces hepatocytes to release EVs with aHSC-tropism. These findings may contribute to the development of an EV-based drug delivery system (DDS) for aHSC-targeted therapy and provide new insights into the role of steatotic hepatocyte-derived EVs in physiological or pathophysiological functions.
The Importance of the Plasma Membrane in Atherogenesis
Authors: Kotlyarov Stanislav , Kotlyarova Anna
Published: October 2022

Atherosclerotic cardiovascular diseases are an important medical problem due to their high prevalence, impact on quality of life and prognosis. The pathogenesis of atherosclerosis is an urgent medical and social problem, the solution of which may improve the quality of diagnosis and treatment of patients. Atherosclerosis is a complex chain of events, which proceeds over many years and in which many cells in the bloodstream and the vascular wall are involved. A growing body of evidence suggests that there are complex, closely linked molecular mechanisms that occur in the plasma membranes of cells involved in atherogenesis. Lipid transport, innate immune system receptor function, and hemodynamic regulation are linked to plasma membranes and their biophysical properties. A better understanding of these interrelationships will improve diagnostic quality and treatment efficacy.
Pulsed Magnetic Treatment of Cobalt for Enhanced Microstructures and Mechanical Properties
Authors: Li Yajie , Guo Han , Zhang Lin , Chen Zhe , Liu Lanhui , Liu Jian
Published: October 2022

In this study, the effects of pulsed magnetic treatment (PMT) on the microstructure and performance of pure bulk cobalt (Co) were investigated to reveal the underlying influencing mechanism of the pulsed magnetic field on ferromagnetic materials. The hardness of the material could be increased by PMT, with a maximum increase of 3.16% when 1T was adopted. The imposition of the pulsed field promoted the transformation of Co from face-centered cubic (FCC) phase to hexagonal close-packed (HCP) phase, which obeys the Shoji–Nishiyama orientation rule, with a decrease of α-Co by 8.60% and an increase of ε-Co by 0.19%. PMT also caused multiplication of defects and the formation of low-angle grain boundaries within the bulk Co. PMT could be an effective way to modify materials to suit engineering applications.
Possibilities of Repairing Functional Surfaces of Molds for Injecting Al Alloys Using Manual GTAW Cladding
Authors: Brezinová Janette , Džupon Miroslav , Viňáš Ján , Vojtko Marek , Brezina Jakub , Vasková Iveta , Puchý Viktor
Published: October 2022

The paper presents the results of research that is focused on the renovation of molds for high-pressure aluminum casting. An analysis of the worn molds was carried out after they were removed from the operator. The extent and mechanism of the wear were determined. GTAW (Gas tungsten arc welding) technology was chosen for the renovation of the shaped parts of the molds. The renovation layers were realized with four types of additional materials Cronitex RC 44, UTP A 73 G 3, UTP A 673 and Dievar® TIG. The quality of the coatings was assessed by destructive as well as non-destructive tests. The mixing of the build-up layers with the base material was determined on the basis of structural analyses. The hardness of the cladding was determined by a metallographic analysis of the cross crowns with the Vickers method. The resistance of the cladding was tested by a complete immersion in a melt of AlSi8Cu3 aluminum alloy which was maintained at a temperature of 680 ± 20 °C in a laboratory resistance furnace for 120 and 300 min. The tribological properties of the produced deposits were determined using the ball-on-disc dry method. Based on the experiments that were carried out, it is possible to recommend the additive material UTP A 73 G 3 for the restoration of the functional surfaces of molds for the injection of Al alloys as the patterns that were created by it have shown the best results in terms of their resistance to Al melt, which is the dominant degradation factor limiting the life of the molds.
A Novel Nano-Composite CSNPs/PVP/CoONPs Coating for Improving Corrosion Resistance of Ti-6Al-4V Alloy as a Dental Implant
Authors: Medany Shymaa S. , Elkamel Renad S. , Abdel-Gawad Soha A. , Fekry Amany M.
Published: October 2022

A new nano-coating of chitosan nanoparticles/polyvinylpyrrolidone/cobalt oxide nanoparticles (CSNPs/PVP/CoONPs) was performed in this work. The newly designed nano-coating comprises a copolymer and inorganic matrices. This nano-coating was used to cover the Ti-6Al-4V alloy surface as a newly designed dental alloy, and then its corrosion properties were studied through different electrochemical techniques. The results reveal that this novel coating improved the corrosion resistance of the Ti-6Al-4V alloy in artificial saliva solution by reaching 17.7 MΩ cm2. The new fabricated biocompatible coating (CSNPs/PVP/CoONPs) greatly enhanced the electrochemical corrosion resistance by giving a high protection efficiency of 90.87% and a low hydrogen evolution rate in artificial saliva solution at 37 °C. The observed results were confirmed by scanning electron microscopy (SEM), Vickers microhardness testing, coating thickness tests, high-resolution transmission electron microscopy (HRTEM), and energy-dispersive X-ray analysis (EDX).
Thermal Performance of the Thin Heat Pipe for Cooling of Solid-State Drives
Authors: Yuan Dongdong , Chen Jiajia , Yang Yong , Zhang Liyong , Liu Songyan , Jiang Huafei , Qian Ning
Published: October 2022

With the rapid development of information science and technology, the demand for computer data processing is increasing, resulting in the rapid growth of the demand for high-power and high-performance solid-state drives (SSDs). The stable operation of SSDs plays an important role in ensuring the reliable working conditions and appropriate temperature of information technology equipment, rack servers, and related facilities. However, SSDs usually have significant heat emissions, putting forward higher requirements for temperature and humidity control, and consequently the heat sink system for cooling is essential to maintain the proper working state of SSDs. In this paper, a new type of thin heat pipe (THP) heat sink is proposed, and the heat transfer performance and cooling effect are experimentally and numerically studied. The numerical results are compared with experimental results, which showed an error within 5%. Single and double heat pipes were investigated under different input powers (from 5 W to 50 W) and different placement angles between 0° and 90°. The heat transfer performance of the new heat sink is analyzed by the startup performance, the evaporator temperature, and the total thermal resistance. The results show that the new double THPs with a 90° angle have a great advantage in the heat transfer performance of SSDs. The research is of great significance for the design and optimization of the SSDs’ cooling system in practical applications.
Surface Post-Treatment Induced by Nanosecond Pulsed Laser Processing of HVAF-Sprayed Fe-Based Metallic Glass Coating
Authors: Wei Xianshun , Liao Zongyi , Wei Shaochong , Chen Guoxing , Lu Haifeng , Liang Yan , Cai Mingwei , Shen Jun
Published: October 2022

The effects of nanosecond pulsed laser processing (NPLP) on the surface morphology, microstructure, and corrosion resistance properties of Fe-based metallic glass coating were investigated. It was found that after pulsed laser processing, the metallic glass coating retained its amorphous structure; however, cracks were generated on the top of the coating. The thickness of the remelted zone reached about 30 μm, and the microstructure became denser after the remelting process. In addition, most of the original defects in the coating disappeared. The corrosion resistance of Fe-based metallic glass coating after NPLP was increased in 3.5 wt.% NaCl solution.
The Use of TOPSIS Method for Multi-Objective Optimization in Milling Ti-MMC
Authors: Kamalizadeh Saeid , Niknam Seyed , Balazinski Marek , Turenne Sylvain
Published: October 2022

This paper presents the use of TOPSIS, a multi-criteria decision-making model combined with the Taguchi method to find the optimum milling parameters. TOPSIS is the Technique for Order Preference by Similarity to the Ideal Solution and shows the value of closeness to the positive ideal solution. This study shows the optimum combination of process parameters using the shortest distance from the ideal solution. The surface roughness and flank tool wear were considered the objectives for simultaneous optimization. After converting multiple responses into a single response, the Taguchi method was used to analyze and determine the optimum machining parameters. According to reported studies, the initial wear behavior and initial cutting conditions have significant effects on the tool wear progress. Several initial cutting parameters can contribute to tool life and therefore can be used to improve both tool life and surface roughness. However, the cutting speed may significantly affect tool wear and ultimate tool life. In this study, an innovative solution was proposed for interrupted machining with two different cutting speeds. The first level cutting speed was used for 1 s and the second level was used for the rest of the process. The experimental results indicate that the initial speed followed by the feed rate significantly affects tool life. In addition, using the proposed strategy with different levels of cutting speed during machining operations led to improved tool life and surface roughness compared to conventional machining with uniform cutting speed throughout the entire process.
Impact of Rotor Design on Its Wear and Work Efficiency of the Aluminum Refining Process
Authors: Prášil Tomáš , Socha Ladislav , Gryc Karel , Svizelová Jana , Saternus Mariola , Merder Tomasz , Pieprzyca Jacek , Gráf Martin
Published: October 2022

Both the wear and the geometry of the rotor determine the efficiency of the process of aluminum refining. The paper presents wear tests of two different rotors: I (pump type) and II (propeller type). The operation of both rotors in industrial conditions was compared and their service life was examined. It was found that rotor I is more durable than the tested rotor II, and at the same time it provides a good level of hydrogen removal throughout the operation period, i.e., 1112 refining cycles. Rotor wear after refining was calculated by 3D scanning. The study also investigated the impact of rotor geometry on the efficiency of the refining process. The degassing efficiency was determined during refining in a foundry using the Dichte Index (DI). The alloy density and the volume of hydrogen removed were also tested for five stages of rotor wear: 0%, 25%, 50%, 75% and 100%. Both new rotors performed worse in removing hydrogen from the liquid alloy than the worn rotors due to their humidity which cannot be eliminated in the initial stage of their operation. A Dross Test was also performed to determine non-metallic impurities and compare size and number of cavities for rotor I and II. The best results of removing non-metallic inclusions by flotation were obtained for rotor I at the end of its operation.
Survey for Computer-Aided Tools and Databases in Metabolomics
Authors: Banimfreg Bayan Hassan , Shamayleh Abdulrahim , Alshraideh Hussam
Published: October 2022

Metabolomics has advanced from innovation and functional genomics tools and is currently a basis in the big data-led precision medicine era. Metabolomics is promising in the pharmaceutical field and clinical research. However, due to the complexity and high throughput data generated from such experiments, data mining and analysis are significant challenges for researchers in the field. Therefore, several efforts were made to develop a complete workflow that helps researchers analyze data. This paper introduces a review of the state-of-the-art computer-aided tools and databases in metabolomics established in recent years. The paper provides computational tools and resources based on functionality and accessibility and provides hyperlinks to web pages to download or use. This review aims to present the latest computer-aided tools, databases, and resources to the metabolomics community in one place.
Different Types of Non-Starch Polysaccharides Alter the Growth, Intestinal Flora and Serum Metabolite Profile of Grass Carp, Ctenopharyngodon idella
Authors: Liu Yu , Fu Xinlangji , Zhou Hang , Fan Jiongting , Huang Huajing , Deng Junming , Tan Beiping
Published: October 2022

Dietary non-starch polysaccharides (NSPs) broadly influence fish intestinal flora and physiological metabolism, but limited information is available on grass carp (Ctenopharyngodon idella). This study investigated the effects of different types of NSPs on the growth, nutrient metabolism status, gut microbiota, and serum metabolome of grass carp. Fish were fed with diets containing 4.4% insoluble NSPs (INSP), 9.24% soluble NSPs (SNSP), 13.64% NSPs (4.4% INSP + 9.24% SNSP, NSP) and non NSPs (FM), respectively, for 9 weeks. Results showed that dietary SNSP decreased protein efficiency ratio and serum protein content, but increased feed coefficient ratio, feed intake, plasma blood urea nitrogen content, and plasma aspartate aminotransferase activity (AST); conversely, dietary INSP decreased plasma AST activity. Dietary INSP and SNSP increased serum free cholesterol content. Dietary NSPs altered the abundance of dominant bacteria and serum metabolite profiles. The differential metabolites between groups were significantly enriched in amino acid synthesis and metabolic pathways. In conclusion, dietary INSP exhibited a growth-promoting effect compared to SNSP. Dietary INSP is beneficial for improving nutrient metabolism and intestinal health. Moreover, dietary NSPs may regulate the physiological metabolism and feeding behavior of grass carp by altering amino acid synthesis and metabolism.
The Glycosyltransferase Pathway: An Integrated Analysis of the Cell Metabolome
Authors: Audet-Delage Yannick , Rouleau Michèle , Villeneuve Lyne , Guillemette Chantal
Published: October 2022

Nucleotide sugar-dependent glycosyltransferases (UGTs) are critical to the homeostasis of endogenous metabolites and the detoxification of xenobiotics. Their impact on the cell metabolome remains unknown. Cellular metabolic changes resulting from human UGT expression were profiled by untargeted metabolomics. The abundant UGT1A1 and UGT2B7 were studied as UGT prototypes along with their alternative (alt.) splicing-derived isoforms displaying structural differences. Nineteen biochemical routes were modified, beyond known UGT substrates. Significant variations in glycolysis and pyrimidine pathways, and precursors of the co-substrate UDP-glucuronic acid were observed. Bioactive lipids such as arachidonic acid and endocannabinoids were highly enriched by up to 13.3-fold (p < 0.01) in cells expressing the canonical enzymes. Alt. UGT2B7 induced drastic and unique metabolic perturbations, including higher glucose (18-fold) levels and tricarboxylic acid cycle (TCA) cycle metabolites and abrogated the effects of the UGT2B7 canonical enzyme when co-expressed. UGT1A1 proteins promoted the accumulation of branched-chain amino acids (BCAA) and TCA metabolites upstream of the mitochondrial oxoglutarate dehydrogenase complex (OGDC). Alt. UGT1A1 exacerbated these changes, likely through its interaction with the OGDC component oxoglutarate dehydrogenase-like (OGDHL). This study expands the breadth of biochemical pathways associated with UGT expression and establishes extensive connectivity between UGT enzymes, alt. proteins and other metabolic processes.
Tea Polyphenols Protect the Mammary Gland of Dairy Cows by Enhancing Antioxidant Capacity and Regulating the TGF-β1/p38/JNK Pathway
Authors: Xu Ran , Zhu Mengran , Cao Jingwen , Guo Mengyao
Published: October 2022

Tea polyphenols (TPs) are the main active substances in tea and they have many beneficial effects, such as anti-inflammation, antioxidant, anti-cancer and metabolic regulation effects. The quality of milk is affected by mammary gland diseases and there are substantial economic losses resulting from reduced milk production as a consequence of inflammatory injury of the mammary gland. In this study, transcriptome analysis and molecular biology techniques were used to study the effects of TPs on inflammatory injury of the mammary gland. After intervention with TPs, a total of 2085 differentially expressed genes were identified, including 1189 up-regulated genes and 896 down-regulated genes. GO analysis showed that differentially expressed genes played an important role in proton transmembrane transport, oxidation–reduction reactions and inflammatory response. KEGG enrichment suggested that differential genes were concentrated in the TGF-β pathway and active oxygen metabolism process. Experiments were performed to confirm that TPs increased SOD, CAT, T-AOC and GSH-Px content along with a reduction in MDA. Meanwhile, TPs inhibited the expression of TGF-β1 and reduced the phosphorylation of p38 and JNK. The expression of inflammatory cytokines IL-1β, IL-6 and TNF-α were significantly decreased after intervention with TPs. In summary, all the data indicated that TPs protected the mammary gland by enhancing the antioxidant capacity and down-regulating the TGF-β1/p38/JNK pathway.
Differentiation of Geographical Origin of White and Brown Rice Samples Using NMR Spectroscopy Coupled with Machine Learning Techniques
Authors: Saeed Maham , Kim Jung-Seop , Kim Seok-Young , Ryu Ji Eun , Ko JuHee , Zaidi Syed Farhan Alam , Seo Jeong-Ah , Kim Young-Suk , Lee Do Yup , Choi Hyung-Kyoon
Published: October 2022

Rice (Oryza sativa L.) is a widely consumed food source, and its geographical origin has long been a subject of discussion. In our study, we collected 44 and 20 rice samples from different regions of the Republic of Korea and China, respectively, of which 35 and 29 samples were of white and brown rice, respectively. These samples were analyzed using nuclear magnetic resonance (NMR) spectroscopy, followed by analyses with various data normalization and scaling methods. Then, leave-one-out cross-validation (LOOCV) and external validation were employed to evaluate various machine learning algorithms. Total area normalization, with unit variance and Pareto scaling for white and brown rice samples, respectively, was determined as the best pre-processing method in orthogonal partial least squares–discriminant analysis. Among the various tested algorithms, support vector machine (SVM) was the best algorithm for predicting the geographical origin of white and brown rice, with an accuracy of 0.99 and 0.96, respectively. In external validation, the SVM-based prediction model for white and brown rice showed good performance, with an accuracy of 1.0. The results of this study suggest the potential application of machine learning techniques based on NMR data for the differentiation and prediction of diverse geographical origins of white and brown rice.
ABHD5—A Regulator of Lipid Metabolism Essential for Diverse Cellular Functions
Authors: Schratter Margarita , Lass Achim , Radner Franz P. W.
Published: October 2022

The α/β-Hydrolase domain-containing protein 5 (ABHD5; also known as comparative gene identification-58, or CGI-58) is the causative gene of the Chanarin-Dorfman syndrome (CDS), a disorder mainly characterized by systemic triacylglycerol accumulation and a severe defect in skin barrier function. The clinical phenotype of CDS patients and the characterization of global and tissue-specific ABHD5-deficient mouse strains have demonstrated that ABHD5 is a crucial regulator of lipid and energy homeostasis in various tissues. Although ABHD5 lacks intrinsic hydrolase activity, it functions as a co-activating enzyme of the patatin-like phospholipase domain-containing (PNPLA) protein family that is involved in triacylglycerol and glycerophospholipid, as well as sphingolipid and retinyl ester metabolism. Moreover, ABHD5 interacts with perilipins (PLINs) and fatty acid-binding proteins (FABPs), which are important regulators of lipid homeostasis in adipose and non-adipose tissues. This review focuses on the multifaceted role of ABHD5 in modulating the function of key enzymes in lipid metabolism.
A Refined Hot Melt Printing Technique with Real-Time CT Imaging Capability
Authors: Muldoon Kirsty , Ahmad Zeeshan , Su Yu-Chuan , Tseng Fan-Gang , Chen Xing , McLaughlin James A. D. , Chang Ming-Wei
Published: October 2022

Personalised drug delivery systems with the ability to offer real-time imaging and control release are an advancement in diagnostic and therapeutic applications. This allows for a tailored drug dosage specific to the patient with a release profile that offers the optimum therapeutic effect. Coupling this application with medical imaging capabilities, real-time contrast can be viewed to display the interaction with the host. Current approaches towards such novelty produce a drug burst release profile and contrasting agents associated with side effects as a result of poor encapsulation of these components. In this study, a 3D-printed drug delivery matrix with real-time imaging is engineered. Polycaprolactone (PCL) forms the bulk structure and encapsulates tetracycline hydrochloride (TH), an antibiotic drug and Iron Oxide Nanoparticles (IONP, Fe3O4), a superparamagnetic contrasting agent. Hot melt extrusion (HME) coupled with fused deposition modelling (FDM) is utilised to promote the encapsulation of TH and IONP. The effect of additives on the formation of micropores (10–20 µm) on the 3D-printed surface was investigated. The high-resolution process demonstrated successful encapsulation of both bioactive and nano components to present promising applications in drug delivery systems, medical imaging and targeted therapy.
Electrochemical Testing of a New Polyimide Thin Film Electrode for Stimulation, Recording, and Monitoring of Brain Activity
Authors: Ong Samuel , Kullmann Aura , Mertens Steve , Rosa Dave , Diaz-Botia Camilo A
Published: October 2022

Subdural electrode arrays are used for monitoring cortical activity and functional brain mapping in patients with seizures. Until recently, the only commercially available arrays were silicone-based, whose thickness and lack of conformability could impact their performance. We designed, characterized, manufactured, and obtained FDA clearance for 29-day clinical use (510(k) K192764) of a new thin-film polyimide-based electrode array. This study describes the electrochemical characterization undertaken to evaluate the quality and reliability of electrical signal recordings and stimulation of these new arrays. Two testing paradigms were performed: a short-term active soak with electrical stimulation and a 29-day passive soak. Before and after each testing paradigm, the arrays were evaluated for their electrical performance using Electrochemical Impedance Spectroscopy (EIS), Cyclic Voltammetry (CV) and Voltage Transients (VT). In all tests, the impedance remained within an acceptable range across all frequencies. The different CV curves showed no significant changes in shape or area, which is indicative of stable electrode material. The electrode polarization remained within appropriate limits to avoid hydrolysis.