bluuebunny/crossref_metadata_2025 huggingface dataset:
[Retracted] An Analysis and Research on Chinese College Students’ Psychological Barriers in Oral English Output from a Cross‐Cultural Perspective
Authors: Zheng Shuai
Published: July 2022

English, as China’s second language, is a part of the overall quality of the people. Mastering this universal language in the world is required to communicate with the world. The most important purpose of learning a language is to communicate, and listening and speaking ability is the most important language skill. However, under the influence of the test‐oriented education model, English teaching in our country places too much emphasis on the cultivation of reading and writing ability and neglects the training of oral expression ability. In this context, this research proposes an oral English teaching assistance program for both teachers and college students and plans to build an artificial‐intelligence‐based oral English teaching assistance system. The combination of ability and oral English teaching solves the drawbacks of traditional oral English teaching and establishes a new teaching form for college students’ oral English teaching. Combined with the popular trend of Internet electronic teaching methods, it realizes a free and online platform for learners to correct and improve pronunciation, laying a certain foundation for the development of mobile online English pronunciation learning in the future and solving the psychological barriers to college students’ oral English output.
Fractional Version of Hermite-Hadamard and Fejér Type Inequalities for a Generalized Class of Convex Functions
Authors: Geng Lei , Saleem Muhammad Shoaib , Aslam Kiran Naseem , Bano Rahat
Published: July 2022

In the present paper, we deal with some fractional integral inequalities for strongly reciprocally

p
,
h

-convex functions. We established fractional version of Hermite-Hadamard and Fejér type inequalities for strongly reciprocally

p
,
h

-convex functions. Our results extend and generalize many exiting results of literate.
[Retracted] Processing and Characterization of Novel Bio‐Waste Hybrid Brick Composites for Pollution Control
Authors: Kumar Naresh , Gaur Piyush , Kaliappan S. , Natrayan L. , Socrates S. , Patil Pravin P. , Thanappan Subash
Published: July 2022

The main focus of this research is to enhance the use of eco‐friendly materials these days. The current materials used in building construction are chemical‐based and are harmful to humans and the environment. This research work has developed a new type of hybrid brick by using natural fibres and waste materials. This research focuses on fabricating novel bricks reinforced with different percentages of coconut waste fibre, wheat straw fibre, waste wood animal dung ash, gypsum, sand, and cement. The fabricated novel brick’s physical, mechanical, chemical, acoustic, and heat‐absorbing properties were evaluated.
[Retracted] DNMT3A Regulates miR‐149 DNA Methylation to Activate NOTCH1/Hedgehog Pathway to Promote the Development of Junctional Osteosarcoma
Authors: Cheng Shigao , Wang Wanchun
Published: July 2022

Purpose. To investigate the DNMT3A/miR‐149/NOTCH1/Hedgehog axis regulating the development of osteosarcoma. Methods. First, microRNA and mRNA expression microarrays were downloaded from the GEO database for osteosarcoma and differentially expressed microRNAs were analyzed. Subsequently, we collected cancerous tissues and corresponding paracancerous tissues from 42 osteosarcoma patients and examined the expression levels of miR‐149, DNMT3A, and NOTCH1 in the samples. Subsequently, miR‐149 was overexpressed in osteosarcoma cells to detect cell proliferation and metastatic ability changes. We then queried the methylation level of the miR‐149 promoter on the bioinformatics website and verified it by experiment. We further demonstrated the expression level of miR‐149 with NOTCH1 using a dual luciferase assay and confirmed the role of NOTCH1 on osteosarcoma cell growth and metastasis by functional rescue assay. Finally, we detected the activation level of the Hedgehog/catenin signaling pathway by WB and immunofluorescence. Results. miR‐149 was significantly low expressed in osteosarcoma tissues and cells, while DNMT3A and NOTCH1 were highly expressed in osteosarcoma tissues and cells, and negatively correlated with miR‐149 expression levels. Overexpression of miR‐149 significantly inhibited the growth and metastasis of osteosarcoma cells in vitro and in vivo, and we found that DNMT3A could promote the methylation modification of the miR‐149 promoter, thereby inhibiting the expression of miR‐149. Subsequently, the experimental results showed that miR‐149 could target negative regulation of NOTCH1, and further overexpression of NOTCH1 in cells with high miR‐149 expression could promote the growth and metastasis of osteosarcoma cells in vitro. Conclusion. The methyltransferase DNMT3A suppresses miR‐149 expression by promoting methylation modification of the miR‐149 promoter, resulting in elevated expression levels of NOTCH1 in cells, therefore exacerbating activation of the Hedgehog signaling pathway and therefore exacerbating the development and progression of osteosarcoma.
Curative Effect of Prebiotics/Probiotics Preparations Combined with Zoledronic Acid + Calcitriol Regimen on Patients with Primary Osteoporosis and Their Influences on Bone Metabolism Markers
Authors: Jia Ruipeng , Liu Ning , Zhu Yanyan , Li Qiaoli
Published: July 2022

Objective. To explore the curative effect of prebiotics/probiotics preparations combined with zoledronic acid + calcitriol regimen on patients with primary osteoporosis (POP) and the influences of prebiotics/probiotics preparations combined with zoledronic acid + calcitriol regimen on markers of bone metabolism. Methods. 126 elderly hospitalized patients with POP in our hospital from January 2020 to December 2021 were divided into the control group (n = 63) and the observation group (n = 63) by the random number table method. The patients in the control group were treated with zoledronic acid and calcitriol, while the patients in the observation group were additionally treated with prebiotics/probiotics preparations. The clinical curative effect, bone metabolism, calcium-phosphorus metabolism indexes, intestinal floras, and cytokines levels before and via treatment between the two groups were compared. Results. The total efficiency of the observation group was higher than that of the control group (

P
<
0.05

). After treatment, the levels of bone gla protein (BGP), total propeptide of type I procollagen (PINP), and β-crosslaps (β-CTX) in both groups were lower than those before treatment, and the levels of BGP, total PINP, and β-CTX in the observation group were lower than those in the control group (

P
<
0.05

). The levels of serum P in the both groups after treatment were lower than those before treatment, and the level of serum P in the observation group was lower than that in the control group (

P
<
0.05

). The number of Escherichia coli after treatment in the two groups were less than that before treatment, and the number of Escherichia coli in the observation group was less than that in the control group (

P
<
0.05

). The number of bifidobacteria and lactobacilli in the two groups after treatment were more than that before treatment, and the number of bifidobacteria and lactobacilli in the observation group were more than those in the control group (

P
<
0.05

). After treatment, the levels of IL-6 and TNF-α in the two groups were lower than those before treatment, and the levels of IL-6 and TNF-α in the observation group was lower than those in the control group (

P
<
0.05

). The levels of IGF-1 in the two groups after treatment were higher than those before treatment, and the levels of IGF-1 in the observation group was higher than that in the control group (

P
<
0.05

). Conclusion. The response rate of prebiotics/probiotics preparations combined with zoledronic acid + calcitriol regimen is high in the treatment of POP patients, which ameliorates bone metabolism and intestinal floras, and suppresses cytokines release in patients with POP.
Enterprise Supply Chain Risk Assessment Based on the Support Vector Machine Algorithm and Fuzzy Model
Authors: Zhang Xiaoni
Published: July 2022

In systems with uncertain information, ambiguity must be taken into account. In this paper, fuzzy set theory concepts are incorporated into support vector machines (SVM). This ensemble preserves the benefits of SVM regression models and fuzzy regression models, where SVM learning theory describes the properties of learning machines that enable them to generalize well, and fuzzy set theory offers an efficient method for capturing the approximate, imprecise properties of the real world. In accordance with the phase space reconstruction theory of dynamical systems, a fuzzy model for enterprise supply chain risk assessment is proposed using the robust nonlinear mapping capability of support vector machines and the characteristic of fuzzy logic that makes it easy to combine prior system knowledge into fuzzy rules. The results demonstrate that the prediction model can not only automatically acquire knowledge from learning data to generate fuzzy rules but can also extract support vectors that can represent the inherent laws of enterprise supply chain risks, drastically reduce the number of support vectors, and accurately predict. Future risk can be accurately predicted. This conclusion suggests that the support vector machine based on a fuzzy model is an effective method for analyzing enterprise supply chain risk.
Fiber Post Removal Using a Conservative Fully Guided Approach: A Dental Technique
Authors: Alfadda Abdullah , Alfadley Abdulmohsen , Jamleh Ahmed
Published: July 2022

This report describes the usefulness of an endodontic template for the removal of a fiber post. A 40-year-old man presented with discomfort in the maxillary left canine. Clinical and radiographic examinations showed tooth #23 with a permanent core material retained with fiber post along with a persistent apical radiolucency. Among the various treatment modalities, nonsurgical root canal retreatment with fiber post removal using a conservative fully guided approach was proposed. After obtaining both the cone-beam computed tomographic images and the cast surface scan, their data were merged using implant planning software (ImplaStation for Windows x64 Bit Beta Version, ProDigiDent, Miami, Florida, USA) and superimposed. The drilling space was planned based on the location, diameter, and apical extent of the fiber post and was virtually overlapped and transferred clinically using a resin template to drill through the fiber post. With guides in position over the rubber dam, drilling was made with increments of 2 mm using a size 4 long-shank round bur (Thomas, Bourges, France) until it exposed the coronal gutta-percha. As soon as the canal was located, K3 rotary files (Sybron Endo, Orange, USA) were used along with chloroform to remove the old obturating materials. Then, additional shaping and cleaning were done with ProTaper Next rotary files (Dentsply Sirona, Ballaigues, Switzerland), sizes X2 and X3, and 5.25% NaOCl irrigation, respectively. The root canal was then dried with paper points and obturated with gutta-percha and AH Plus sealer (Dentsply Sirona, Ballaigues, Switzerland) using the continuous-wave compaction technique. Finally, the tooth was temporarily restored using the double seal technique with zinc oxide and zinc sulfate-based temporary material (Cavit W; 3M ESPE, St. Paul, MN, USA) and resin-modified glass ionomer material (Photac Fil; ESPE, Norristown, PA, USA) filling materials and referred for the final restoration.
The Ergonomic Knowledge and Practice of Dental Students in a Tertiary Institution in South Africa
Authors: Moosa U. K. , Bhayat A.
Published: July 2022

Proper ergonomic practices are crucial practices to be considered when working on dental patients, and are often neglected during the dental students’ training. We aimed to assess the dental students’ knowledge of ergonomics as well the prevalence of their musculoskeletal pain. Methods. A cross sectional analytical study was conducted at a dental school in South Africa. The sample included all senior dental, and dental hygiene students registered in the 2021 academic year. A modified questionnaire using an online platform assessed the student’s level of practical and theoretical knowledge of ergonomics; their personal assessment of their competency in implementing ergonomics; and their prevalence of musculoskeletal pain. The knowledge scores were calculated to determine the overall scores. Data was analysed using the Statistical Package for the Social Sciences (SPSS). Ethical clearance was obtained from the Faculty Ethical Committee and all information was anonymous. Results. The response rate was 52% (n = 106), the mean knowledge score was 68%, and 53% reported to be able to successfully implement their ergonomic knowledge practically. The prevalence of musculoskeletal pain increased from 32% prior to entering dental school to 78% during dental school. Pain was most commonly reported to be on the back (77%), neck (51%), and shoulders (51%). Conclusion. The majority of students had an average level of knowledge regarding ergonomic principles, however, the practical application was poor. Many students reported to have suffered from back pain which seemed to have started since treating patients. The supervisors should educate and assist students to practice healthy ergonomic postures during clinical and pre-clinical sessions.
The Application of Ozone Micro-nano Bubble Treatment Vegetable Fresh-Keeping Technology in Air Logistics Transportation
Authors: Yang Yang , Chen Qiang
Published: July 2022

In recent years, fresh fruits and vegetables have been sought after by Chinese people. The fresh-keeping technology, storage, and transportation of fruits and vegetables have also attracted a large number of people’s attention. Various methods of preservation, storage, and transportation of fruits and vegetables have begun to appear in the society. Micro and nanobubbles have the characteristics of long stay time, larger than the surface, high surface negative electricity, strong reliability, high efficiency of heat transfer, can cause oxygen free radicals, can greatly improve the actual effect of ozone and ozone utilization rate, and reduce the operation cost. This article aims to study the application of ozone micro-nano bubble processing vegetable fresh-keeping technology in air logistics and transportation, and put forward the idea of applying ozone micro-nano bubble processing fresh-keeping technology to fruits and vegetables fresh-keeping and transportation more widely. This article focuses on the introduction of ozone micro-nano bubbles, fresh-keeping technology, air transportation, and experiments on some fresh-keeping technologies in the article. The experimental results show that the vegetable preservation technology based on ozone micro-nano bubbles can better maintain the moisture and nutrients in the vegetables. The preservation technology of ozone micro-nano bubble treatment has improved the preservation of fruits and vegetables by 12%.
Motion Rehabilitation Robot Control Based on Human Posture Information
Authors: He Guangfeng
Published: July 2022

In order to meet the needs of postoperative rehabilitation training of lower limbs, a motion rehabilitation robot control system based on human posture information is proposed in this paper. The functions of active/passive training mode control, movement posture and EMG signal acquisition, WiFi communication, safety protection, etc. of the lower limb rehabilitation robot are realized. The recognition and analysis of the training process are realized by using random forest machine learning algorithm and linear regression algorithm. The experimental results show that in the first row of the confusion matrix of the random forest algorithm, 7316 data are correctly identified as speed

a

and only one data is incorrectly identified as speed

B

, which is superior to other algorithms. In conclusion, the developed control and monitoring system of lower limb rehabilitation robot can be portable controlled by Android and can realize intelligent analysis of the training process through the monitoring signals in the training process. At the same time, the random forest algorithm has more advantages than the linear regression algorithm in motion recognition, which is of positive significance to the automatic monitoring and intelligent control of the training process.
Benefits of Fluctuating Exchange Rates on the Investor’s Wealth
Authors: Doctor Obonye , Lungu Edward M.
Published: July 2022

We consider a problem of maximizing the utility of an agent who invests in a stock and a money market account incorporating proportional transaction costs

λ
>
0

and foreign exchange rate fluctuations. Assuming a HARA utility function

U

c

=

c

p

/
p

for all

c
≥
0

,

p
<
1

,

p
≠
0

, we suggest an approach of determining the value function. Contrary to fears associated with exchange rate fluctuations, our results show that these fluctuations can bring about tangible benefits in one’s wealth. We quantify the level of these benefits. We also present an example which illustrates an investment strategy of our agent.
The Value of Dynamic Contrast‐Enhanced Magnetic Resonance Imaging (DCE‐MRI) in the Differentiation of Pseudoprogression and Recurrence of Intracranial Gliomas
Authors: Jing Hui , Yan Xuhong , Li Junjie , Qin Danlei , Zhang Ning , Zhang Hui
Published: July 2022

Objective. The objective of this study was to determine the value of dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI) in assessing postoperative changes in intracranial gliomas. Method. A total of fifty‐one patients who had new enhanced lesions after surgical resection followed by standard radiotherapy and chemotherapy were collected retrospectively from October 2014 to June 2021. The patients were divided into a pseudoprogression group (15 cases) and a recurrence group (36 cases) according to the pathological results of the second operation or a follow‐up of more than six months. The follow‐up data of all patients were complete, and DCE‐MRI was performed. The images were processed to obtain the quantitative parameters Ktrans, Ve, and Kep and the semiquantitative parameter iAUC, which were analysed with relevant statistical software. Results. First, the difference in Ktrans and iAUC values between the two groups was statistically significant (P < 0.05), and the difference in Ve and Kep values was not statistically significant (P > 0.05). Second, by comparing the area under the curve, threshold, sensitivity and specificity of Ktrans, and iAUC, it was found that the iAUC threshold value was slightly higher than that of Ktrans, and the specificity of Ktrans was equal to that of iAUC, while the area under the curve and sensitivity of Ktrans were higher than those of iAUC. Third, Ktrans and iAUC had high accuracy in diagnosing recurrence and pseudoprogression, and Ktrans had higher accuracy than iAUC. Conclusion. In this study, DCE‐MRI has a certain diagnostic value in the early differentiation of recurrence and pseudoprogression, offering a new method for the diagnosis and assessment of gliomas after surgery.
Overlapping Cell Segmentation of Cervical Cytology Images Based on Nuclear Radial Boundary Enhancement
Authors: Wang Tao , Lan Hong , Niu Landing , Fan Zhipeng , Yang Guihua
Published: July 2022

The accurate segmentation of cervical cell images is one of the key steps of the cervical cancer computer-aided diagnosis system. For the problem of overlapping cell and boundary blurring in cervical cell clusters, the researchers propose a segmentation algorithm based on the nuclear radial boundary enhancement for overlapping cell of cervical cytology images. This method not only suppresses the noise of cervical cytology images but also preserves the contrast of overlapping cell boundary. The researchers generate the weight graph by the candidate contour points and contour line segment attributes and utilize the dynamic programming algorithm to find the shortest path in the weight graph. The shortest path corresponds to the coarse segmentation contour in the cell image. The level set model is used to finely segment the obtained coarse cell segmentation boundary, so as to obtain the final cervical cell boundary. Through the quantitative and qualitative evaluation results, such as dice similarity coefficient, true positive rate, and false positive rate, it can be seen that the overlapping cell segmentation algorithm in this paper has achieved better segmentation results. Compared with other current overlap cell segmentation algorithms, the segmentation results obtained in this paper have greater advantages.
Clinical Study on Prevention of Irinotecan-Induced Delayed-Onset Diarrhea by Hot Ironing with Moxa Salt Packet on Tianshu and Shangjuxu
Authors: Lai Xianghong , Wang Anmei
Published: July 2022

Objective. To study the clinical efficacy of hot ironing of the Tianshu and Shangjuxu with moxa salt packet to prevent irinotecan (CPT-11)-induced delayed-onset diarrhea (IIDD). Methods. A randomized controlled study was conducted on a sample of 120 patients with advanced colorectal cancer who were hospitalized in our oncology department and treated with FOLFIRI chemotherapy regimen from February 2018 to July 2021. They were equally divided into study group (n = 60) and control group (n = 60) according to whether they were treated with hot ironing with moxa salt packs or not. The general conditions, occurrence of IIDD, occurrence of delayed chemotherapy due to IIDD, time of occurrence and duration of IIDD, Karnofsky performance score (KPS) score, occurrence of leukopenia, and myelosuppression were compared between the two groups. Result. The incidence of grade 1, 2, 3, and 4 diarrhea in the study group was 11.67% (7/60), 5.00% (3/60), 3.33% (2/60), and 0.00% (0/60), respectively, while the incidence of grade 1, 2, 3, and 4 diarrhea in the control group was 21.67% (13/60), 8.33% (5/60), 10.00% (6/60), and 3.33% (2/60). The incidence of severe diarrhea and total diarrhea in the study group was (3.33% and 20.00%) lower than that in the control group (13.33% and 43.33%) (

P
<
0.05

). The incidence of delayed chemotherapy was lower in the study group (8.33%) (1/12) than in the control group (23.08%) (6/26) but the difference between the groups was not statistically significant (

P
>
0.05

). The time to onset of IIDD in the study group (6.45 ± 1.53) days was comparable to that in the control group (6.40 ± 1.77 days) (

P
>
0.05

), but the duration of IIDD in the study group (3.25 ± 1.05 days) was shorter than that in the control group (5.70 ± 1.72 days) (

P
<
0.05

). After treatment, the incidence of KPS improvement, stabilization, and reduction in the study group was 38.33% (23/60), 51.67% (31/60), and 10.00% (6/60), respectively, the incidence of KPS improvement, stabilization, and reduction in the control group was 23.33% (14/60), 50.00% (30/60), and 26.67% (16/60), respectively, and the percentage of KPS reduction in the study group was less than that in the control group (

P
<
0.05

). During the observation period after treatment, the total incidence of leucopenia in the study group was 11.67% (7/60) which is lower than 31.67% (19/60) in the control group (

P
<
0.05

). During the observation period after treatment, the incidence of III°+°IV myelosuppression in the study group was 5.00% (3/60) which is lower than 25.00% (15/60) in the control group (

P
<
0.05

). Conclusion. The hot ironing with moxa salt packet on Tianshu and Shangjuxu was more effective in preventing IIDD, which could reduce the incidence and severity of IIDD, shorten the duration of diarrhea and significantly increase the quality of life of patients with no significant adverse effects.
Nanoencapsulation of 4-Propylguaiacol in β-Cyclodextrin, Ethyl Cellulose, and Polyvinylpyrrolidone
Authors: Kariuki Margaret W. , Hassanali Ahmed , Ng’ang’a Margaret M.
Published: July 2022

We previously identified 4-propylguaiacol to be a highly potent repellent against Rhipicephalus appendiculatus, which transmits East Coast Fever in cattle. So far, the major method that has been employed for tick control is the use of acaricides, which so far has posed a number of challenges. Encapsulation technology may offer a long-term solution to the existing problems by dispensing the repellent at a controlled rate. 4-Propylguaiacol was encapsulated in various nanoparticles, which included β-cyclodextrin, ethyl cellulose, and polyvinylpyrrolidone. The inclusion of 4-propyl guaiacol in the resulting complexes was confirmed by FT-IR, XRD, and SEM analysis. All the sharp peaks belonging to each of the encapsulating polymers were observed. However, some of the characteristic peaks of 4-propylguaiacol disappeared in the complex formed. The rates and duration of release of 4-propylguaiacol from 0.2 g of each inclusion complex were then compared at 38–40°C every 3 hours for 24 hrs. The observed rates of release for 4-propylguaiacol were 0.396 mg/hr., 0.632 mg/hr., and 0.648 mg/hr. Rate from β-cyclodextrin, ethyl cellulose, and PVP inclusion complexes, respectively. The release rate of 4-propylguaiacol in the β-cyclodextrin complex was more controlled than it was in ethyl cellulose and PVP complexes. This controlled release rate exhibited by the β-cyclodextrin complex in small doses for a relatively long time provides a potential tool for dispensing repellents on cattle to protect them from tick bites.
Efficacy of Traditional Chinese Medicine Injection in Preventing Oxaliplatin-Induced Peripheral Neurotoxicity: An Analysis of Evidence from 3598 Patients
Authors: Chen Zhi-Ying , Liu Yue , Wei Yuan , Deng Lin-Yao , Zhang Qiang
Published: July 2022

Background. Oxaliplatin is an effective chemotherapeutic agent for the treatment of malignant tumors. However, severe oxaliplatin-induced peripheral neurotoxicity (OIPN) has been well documented. Traditional Chinese medicine injections (TCMIs) have shown significant efficacy in preventing OIPN. However, it is difficult for clinicians to determine the differences in the efficacy of various TCMIs in preventing OIPN. The aim of this study was to compare the efficacy of various TCMIs in preventing OIPN through a network meta-analysis (NMA) to further inform clinical decision-making. Methods. The Chinese Journal Full Text Database, Chinese Biomedical Literature Database, Wanfang Data Knowledge Service Platform, Chinese Science and Technology Journal Full Text Database, the Cochrane Library, Web of Science, PubMed, and Embase databases were searched for randomized controlled trials (RCTs) of TCMIs for OIPN prevention. The retrieval time was from the establishment of the database to April 12, 2021. NMA was performed using Stata 14.0 software after 2 evaluators independently screened the literature, extracted information, and evaluated the risk of bias of the included studies. Results. A total of 45 eligible RCTs involving 3598 cancer patients and 13 TCMIs were included. The 13 TCMIs included Xiaoaiping injection (XAPI), compound kushen injection (CKSI), Aidi injection (ADI), Brucea javanica oil emulsion injection (BJOEI), Shenmai injection (SMI), Kangai injection (KAI), Astragalus injection (AI), elemene emulsion injection (EEI), Shenfu injection (SFI), Shenqi Fuzheng injection (SIFZI), Kanglaite injection (KLEI), Huachansu injection (HCSI), and lentinan injection (LI). NMA results showed that AI was superior to AD and SIFZI was superior to ADI in reducing the incidence of grade I neurotoxicity. SIFZI was superior to EEI and ADI, and BJOEI was superior to chemotherapy alone in reducing the incidence of grade II neurotoxicity. SMI was superior to LI and CKSI in reducing the incidence of grade III neurotoxicity. SIFZI was superior to LI, BJOEI, XAPI, EEI, SMI, chemotherapy alone, HCSI, KLEI, and ADI in reducing the total incidence of grade I–IV neurotoxicity. SFI was superior to ADI. Based on the SUCRA values, AI was the most likely intervention to reduce the incidence of grade I neurotoxicity, SIFZI was the most likely intervention to reduce the total incidence of grade II and I–IV neurotoxicity, and SMI was the most likely intervention to reduce the incidence of grade III and IV neurotoxicity. Conclusion. TCMIs can prevent OIPN to some extent, among which SIFZI, SMI, and AI may be the most promising TCMIs. However, given the limitations of current studies, more well-designed, high-quality clinical trials will be needed in the future to validate the benefits of TCMIs.
Multiobjective Synchronous Control of Heavy-Duty Vehicles Based on Longitudinal and Lateral Coupling Dynamics
Authors: Lu Yongjie , Wang Tongtong , Zhang Hangxing
Published: July 2022

The steering system, suspension system, and braking system of the vehicle are interrelated, so the ride comfort and handling stability of the vehicle are also closely related. But the vertical and lateral dynamics equations and controls system of the vehicle are always independent of each other, and the multiobjective control is generally achieved through the coordination of control algorithms. In this paper, taking the dynamic load of the tire as a link, the vertical dynamic model and the lateral dynamic model of heavy-duty vehicle are coupled. When the heavy-duty vehicle is turning, the proposed coupling model not only reflects the influence of the front wheel angle on the vertical motion and the vertical tire load, but also reflects the unevenness of the road surface on vehicle lateral motion. In order to improve the handling stability and transient safety of the vehicle, a synchronous control system combining six-wheel steering and front wheel active steering is proposed. It solves the problem that it is difficult to effectively track the desired yaw rate for the three-axle all-wheel steering vehicle with the middle rear wheel angle as the control input. Under the framework of the vehicle vertical/lateral unified coupling dynamics model, the semiactive suspension system controlled by fuzzy PID and the six-wheel active steering system combined with fuzzy control and fuzzy PID control are integrated. It is verified that the synchronous control method effectively optimizes the vertical and lateral motion characteristics of heavy-duty vehicles during steering and, at the same time, improves the ride comfort and steering stability.
Exploration of Strategies for Organic Integration of Labor Education and Occupational Therapy for College Students
Authors: Du Linna , Wang Weizheng
Published: July 2022

This paper analyzes the actual functions of the labor education and occupational therapy phase through an in-depth study of labor education and occupational therapy for college students and explores the strategies of organic integration of labor education and occupational therapy for college students. This paper carries out a holistic theoretical construction of labor education in schools and systematically analyzes the components of labor education objectives in colleges and universities, labor education contents in schools, labor education implementation in schools, and labor education evaluation in schools. The main goal of labor education in colleges and universities is to guide students in establishing a scientific concept of labor and constructing a labor education resource system. It focuses on strengthening the construction and improvement of the labor education theoretical system, promoting the construction of labor education disciplines and professional courses, and attaching importance to the training of labor education teachers in the new era to contribute to the perfection of labor education. The system of labor education practice should be innovated. Of course, the labor practice activities based on institutionalization should be implemented. The cycle of labor activities based on the principle of continuity should be strengthened, and the effectiveness of labor education should be improved totally from explicit and implicit instructions. The core of occupational therapy is to help college students adapt to social work, give full play to their self-worth, obtain economic resources, and improve self-confidence. The organic integration of labor education and occupational therapy shows that it can help students ease their social adaptability and adapt to social functions, improve the reemployment rate, and improve students’ overall health. Therefore, the practical research on labor education and occupational therapy should be strengthened.
Robustness Analysis of CPPS considering Power Flow Constraints
Authors: Xu Zhengwei , Ge Yuan , Lin Qiyou , Chen Renfeng , Cao Jin , Yu Nuo
Published: July 2022

Comprehensively considering the power flow constraints of the power network, the cyber-physical power system (CPPS) network integration model is established by combining with the topological structure information of the power network and information network. The Newton–Raphson method is used to solve the AC power flow distribution in the power network. Based on the interdependent network theory, a CPPS cascading fault analysis procedure considering the power flow constraints is given. Finally, the importance of CPPS network nodes is evaluated and analyzed. Simulation experiments are carried out with the IEEE39 node system as an example. The results show that some electrical components failures in the power network may lead to large-scale transfer of power flow, resulting in overloading of other electrical components or transmission lines. It promotes further cascade propagation of failures in the CPPS network, which eventually leads to a sharp decrease in the robustness of CPPS.
A Low-Temperature Hydrothermal Synthesis of Prussian Blue Nanocrystal and Its Application in H2O2 Detection
Authors: Yang J. , Li D. H. , Ji L. L.
Published: July 2022

Uniform Prussian blue Fe3[Fe(CN)6]2 nanocrystals were synthesized by a direct dissociation and reduction of the single-Fe(III)-source precursor K3Fe(CN)6 under low-temperature hydrothermal conditions. UV-visible absorption spectrum, Fourier transform infrared spectrum, X-ray diffraction, field emission scanning electron microscope, X-ray photoelectron spectra, high-resolution transmission electron microscopy, and electrochemical testing were used to characterize and verify the synthesized Prussian blue nanocrystal product. The size of the synthesized product had a strong dependence on the acidity condition and the concentration of K3Fe(CN)6 solution. This result may facilitate not only the exploration of preparing Fe3[Fe(CN)6]2 nanocrystals for particular applications but also an in-depth explanation of the nature of the hydrothermal reaction. The Prussian blue nanocrystals were deposited onto an electrode support through lyotropic liquid crystalline templates to detect hydrogen peroxide (H2O2) by reduction reaction. Cyclic voltammograms showed that the Prussian blue modified electrode was of excellent electrocatalytic activity for H2O2. This electrode demonstrated a detection limit (1 × 10−7 M) and a linear range starting from the detection limit and extending over 6 orders of magnitude of H2O2 concentrations (1 × 10−7 to 1 × 10−1 M), which was of excellent performance in detecting H2O2.
Predicting the Elastic Modulus of Nanoparticle-Reinforced Polymer Matrix Composites Based on Digital Image Processing and Finite Elements
Authors: Jiang Zhenghong , Zhou Chunrong
Published: July 2022

“Composite” means composition of two or more separate components. Composites are materials composed of two or more components that are chemically separated from each other on a macroscopic scale, and there are interfaces between these components. Conceptually, fiber-reinforced composites have existed since about 800 B.C. The aim of this paper is to predict the elastic modulus of nanoparticle-reinforced polymer matrix composites based on digital image processing and finite elements and to investigate the presence of interfaces in three-phase particle-reinforced composites. In this paper, the interfacial layer is designed as a spring model with the help of the effective modulus law, a statistical debonding criterion is proposed to represent the proceeding changes, and metallurgical methods are used to optimize the particles and prepare different composites with uniform dispersion. The experimental results of this paper show that the highest increase in tensile strength of the composites is about 8% and the highest increase in elastic modulus is 40% after the addition of nanoparticle materials, and the highest increase in tensile strength is 18% and the highest increase in elastic modulus is 50% after the addition of CNFs.
Characteristics and Resource Utilization Associated with Frequent Users of Emergency Departments
Authors: Lee Wan-Ling , Chen Wei-Ting , Hsiao Fei-Hsiu , Huang Chien-Hua , Huang Ling-Yun
Published: July 2022

Background. Frequent emergency department (ED) users place a huge influence and burden on healthcare systems and medical costs. In Taiwan, citizens have very easy access to medical services and the national health insurance (NHI) puts very few restrictions on the frequency and facilities which the patients go to. However, there is still a certain percentage of frequent ED users in Taiwan, and yet, there are few research studies investigating the features of such users and their impact on the healthcare system. We conducted this study to investigate the prevalence and characteristics of the repeated ED users in a tertiary care medical center with more than 80000 emergency visits in a year and hypothesized that frequent ED users have unique medical and social characteristics and results in increased medical expense. Methods. We searched the integrated medical database of an urban tertiary medical center in 2017. We compared frequent ED users (≧4 visits/year) with nonfrequent users (<4 visits/year) with regards to the medical history, distance from home to the hospital, main visiting purposes, whether patients had used outpatient care or other medical resources at the same time, and the charge to the patients for each visit. Results. In 2017, 2191 patients (3.37%) were listed as frequent users and accounted for 12166 visits (14.20%). Most of the frequent users were over 65 years old (53.1%) and more than half of them had suffered from cancer (55.1%). The most significant features of frequent ED users were male, educational attainment below university, low-income households, drug or food allergies, terminal stage of illness, possession of IC Cards for Severe Illness, hospitalization in the past year, multiple outpatient visits in same year, and with certain medical history including anemia, cerebrovascular accident, congestive heart failure, peptic ulcer disease, ileus, cirrhosis, chronic obstructive pulmonary disease, and psychiatric disease. There were significant differences between frequent and nonfrequent users in disposition and median charge per visit (US$137 vs. $117,

p
<
0.001

). Conclusions. Frequent users of ED are a heterogeneous group who usually suffer from multiple chronic diseases. There were higher rates of hospital admission and medical costs among frequent ED users compared to nonfrequent users. In addition to emergency services, frequent users also utilized outpatient resources heavily.
Multiobjective Optimization of Stress-Release Boot of Solid Rocket Motor under Vertical Storage Based on RBF Model
Authors: Miao Qiuwen , Zhang Huihui , Shen Zhibin , Zhou Weiyong
Published: July 2022

Stress-release boot can effectively improve the structural integrity of SRM (solid rocket motor), but it will also influence the loading fraction and interior ballistic performance, so the purpose of this paper is to propose a multiobjective optimization method for stress-release boot. The design variables are the front and rear depth of the stress-release boot, and four optimization variables were determined according to the analysis of SRM performance. To optimize a SRM with star and finocyl grain, the RBF (radial basis functions) model that satisfies the accuracy requirements was established based on parametric modeling technology and the OPLHS (Optimal Latin Hypercube Sampling) method. Subsequently, the Pareto front was obtained based on the NCGA-II algorithm. And an optimal solution was obtained based on the evolutionary algorithm and weighted method. Compared with the initial SRM, the maximum Von Mises strain of the grain, the maximum principal stress of the insulator/cladding interface, the maximum axial displacement, and the volume increment decreased by 19.92%, 35.33%, 4.80%, and 4.42%, respectively. The optimization design method proposed in this paper has significant advantages in computational efficiency for the optimization of SRM and can take into account various performances of SRM, which not only is suitable for the optimization design of stress-release boot but also provides guidance for the optimization design of other shape parameters of SRM.
Analysis and Evaluation of Factors Influencing the Low-Carbon Effect of Urban High-Rise Settlement Planning Schemes Based on AHP-Fuzzy Comprehensive Evaluation Method
Authors: Lu Ming , Sun Guofei , He Zichong
Published: July 2022

With the rise of low-carbon concept and the trend of low-carbon planning, the evaluation of low-carbon planning has been paid more and more attention by the academic and planning circles. Carbon evaluation has become a hot topic after “environmental evaluation” and “green evaluation.” In order to promote the important content of energy conservation and sustainable development in the construction of low-carbon cities, this paper constructs and plans the content of low-carbon city planning and construction. On the basis of the effectiveness evaluation index system, this paper discusses the linkage between analytic hierarchy process and fuzzy comprehensive evaluation method and makes a comprehensive quantitative evaluation on the effectiveness of case planning EIA. Combining the advantages of analytic hierarchy process and fuzzy comprehensive evaluation method, the subobjectives and weights of each index are determined by the analytic hierarchy process. The multi-level fuzzy comprehensive evaluation method is used to evaluate the factors that affect the low-carbon effect of urban high-rise residential district planning. This study leads the new trend of future urban construction, and the construction of low-carbon residential areas, as an important part of promoting urban sustainable development, is the core component of future low-carbon urban planning and construction.
Based on Quantum Topological Stabilizer Color Code Morphism Neural Network Decoder
Authors: Ding Li , Wang Haowen , Wang Yinuo , Wang Shumei
Published: July 2022

Solving for quantum error correction remains one of the key challenges of quantum computing. Traditional decoding methods are limited by computing power and data scale, which restrict the decoding efficiency of color codes. There are many decoding methods that have been suggested to solve this problem. Machine learning is considered one of the most suitable solutions for decoding task of color code. We project the color code onto the surface code, use the deep Q network to iteratively train the decoding process of the color code and obtain the relationship between the inversion error rate and the logical error rate of the trained model and the performance of error correction. Our results show that through unsupervised learning, when iterative training is at least 300 times, a self-trained model can improve the error correction accuracy to 96.5%, and the error correction speed is about 13.8% higher than that of the traditional algorithm. We numerically show that our decoding method can achieve a fast prediction speed after training and a better error correction threshold.
Feature Learning-Based Generative Adversarial Network Data Augmentation for Class-Based Few-Shot Learning
Authors: Subedi Bharat , Sathishkumar V. E. , Maheshwari V. , Kumar M. Sandeep , Jayagopal Prabhu , Allayear Shaikh Muhammad
Published: July 2022

As training deep neural networks enough requires a large amount of data, there have been a lot of studies to deal with this problem. Data augmentation techniques are basic solutions to increase training data using existing data. Geometric transformations and color space augmentations are well-known augmentation techniques, but they still require some manual work and can generate limited types of data only. Therefore, there are many interests in generative-model-based augmentation lately, which can learn the distribution of data. This study proposes a set of GAN-based data augmentation methods that can generate good quality training data. The proposed networks, f-DAGAN (data augmentation generative adversarial networks), have been motivated by the DAGAN that learns data distribution from two real data. The basic f-DAGAN uses dual discriminators handling both generated data and generated feature spaces for better learning the given data. The other versions of f-DAGANs have been proposed for generating hard or easy data that have additional dual classifiers for both generated data and feature spaces to control the generator. Hard data is useful for optimized training to increase the target performance such as classification accuracy. Easy data generation can be used especially in few-shot learning. The quality of generated data has been validated in two ways: using t-SNE visualization of generated data and classification accuracy by training with generated data using the MNIST data set. The t-SNE representations show that data generated by f-DAGAN are evenly distributed for every class better than the exiting generative model-based augmentation methods. The f-DAGAN also shows the best classification accuracy by training with generated data. The f-DAGAN version for easy and hard data generation generates data well from five-shot learning and performs well in sample data generation experiments.
Lipid-Associated Macrophages Are Induced by Cancer-Associated Fibroblasts and Mediate Immune Suppression in Breast Cancer
Authors: Timperi Eleonora , Gueguen Paul , Molgora Martina , Magagna Ilaria , Kieffer Yann , Lopez-Lastra Silvia , Sirven Philemon , Baudrin Laura G. , Baulande Sylvain , Nicolas André , Champenois Gabriel , Meseure Didier , Vincent-Salomon Anne , Tardivon Anne , Laas Enora , Soumelis Vassili , Colonna Marco , Mechta-Grigoriou Fatima , Amigorena Sebastian , Romano Emanuela
Published: July 2022

Tumor-associated macrophages (TAM) play a detrimental role in triple-negative breast cancer (TNBC). In-depth analysis of TAM characteristics and interactions with stromal cells, such as cancer-associated fibroblast (CAF), could provide important biological and therapeutic insights. Here we identify at the single-cell level a monocyte-derived STAB1+TREM2high lipid-associated macrophage (LAM) subpopulation with immune suppressive capacities that is expanded in patients resistant to immune checkpoint blockade (ICB). Genetic depletion of this LAM subset in mice suppressed TNBC tumor growth. Flow cytometry and bulk RNA sequencing data demonstrated that coculture with TNBC-derived CAFs led to reprogramming of blood monocytes towards immune suppressive STAB1+TREM2high LAMs, which inhibit T-cell activation and proliferation. Cell-to-cell interaction modeling and assays in vitro demonstrated the role of the inflammatory CXCL12–CXCR4 axis in CAF–myeloid cell cross-talk and recruitment of monocytes in tumor sites. Altogether, these data suggest an inflammation model whereby monocytes recruited to the tumor via the CAF-driven CXCL12–CXCR4 axis acquire protumorigenic LAM capacities to support an immunosuppressive microenvironment.

Significance:

This work identifies a novel lipid–associated macrophage subpopulation with immune suppressive functions, offering new leads for therapeutic interventions in triple-negative breast cancer.
Broadening the MIND: Tafasitamab and Lenalidomide versus Synthetic Controls
Authors: Cherng Hua-Jay J. , Westin Jason R.
Published: July 2022

Tafasitamab and lenalidomide were approved for second-line treatment of diffuse large B-cell lymphoma (DLBCL) based on a single-arm phase II study. This combination was superior to routine immunochemotherapy regimens when comparing matched observational cohorts. “Synthetic” control groups may support use of novel DLBCL therapies in the absence of randomized studies.

See related article by Nowakowski et al., p. 4003