bluuebunny/crossref_metadata_2025 huggingface dataset:
Biomechanical Properties of the Internal Limiting Membrane after Intravitreal Ocriplasmin Treatment
Authors: Vielmuth Franziska , Schumann Ricarda G. , Spindler Volker , Wolf Armin , Scheler Renate , Mayer Wolfgang J. , Henrich Paul B. , Haritoglou Christos
Published: April 2016

Purpose: To assess the stiffness of the human internal limiting membrane (ILM) and evaluate potential changes of mechanical properties following intravitreal ocriplasmin injection for vitreomacular traction. Methods: This is an interventional comparative case series of 12 surgically excised ILM specimens consecutively obtained from 9 eyes of 9 patients after unsuccessful pharmacologic vitreolysis with ocriplasmin. During the same time period, 16 specimens from 13 other eyes without ocriplasmin treatment were harvested during vitrectomy and served as controls. All patients presented with macular holes or vitreomacular traction and underwent vitrectomy with ILM peeling either with or without brilliant blue (BB) staining. All specimens were analyzed using atomic force microscopy with scan regions of 25 × 25 μm. In all specimens, both the retinal side and vitreal side of the ILM were analyzed. Results: Atomic force microscopy revealed no significant differences in elasticity of ILM specimens removed from eyes with or without ocriplasmin treatment. Undulated areas of the retinal side presented stiffer than the vitreal side of the ILM. Topographical mapping of both the vitreal and retinal side of the ILM showed no apparent alteration of the morphology in ocriplasmin-treated eyes compared to untreated eyes. Staining with BB resulted in an increase of tissue stiffness. Conclusions: Intravitreal injection of ocriplasmin does not change biomechanical properties of the human ILM. There is no evidence of a potential enzymatic effect of ocriplasmin interfering with the stiffness of this basement membrane.
Rare-Variant Kernel Machine Test for Longitudinal Data from Population and Family Samples
Authors: Yan Qi , Weeks Daniel E. , Tiwari Hemant K. , Yi Nengjun , Zhang Kui , Gao Guimin , Lin Wan-Yu , Lou Xiang-Yang , Chen Wei , Liu Nianjun
Published: April 2016

Objective: The kernel machine (KM) test reportedly performs well in the set-based association test of rare variants. Many studies have been conducted to measure phenotypes at multiple time points, but the standard KM methodology has only been available for phenotypes at a single time point. In addition, family-based designs have been widely used in genetic association studies; therefore, the data analysis method used must appropriately handle familial relatedness. A rare-variant test does not currently exist for longitudinal data from family samples. Therefore, in this paper, we aim to introduce an association test for rare variants, which includes multiple longitudinal phenotype measurements for either population or family samples. Methods: This approach uses KM regression based on the linear mixed model framework and is applicable to longitudinal data from either population (L-KM) or family samples (LF-KM). Results: In our population-based simulation studies, L-KM has good control of Type I error rate and increased power in all the scenarios we considered compared with other competing methods. Conversely, in the family-based simulation studies, we found an inflated Type I error rate when L-KM was applied directly to the family samples, whereas LF-KM retained the desired Type I error rate and had the best power performance overall. Finally, we illustrate the utility of our proposed LF-KM approach by analyzing data from an association study between rare variants and blood pressure from the Genetic Analysis Workshop 18 (GAW18). Conclusion: We propose a method for rare-variant association testing in population and family samples using phenotypes measured at multiple time points for each subject. The proposed method has the best power performance compared to competing approaches in our simulation study.
Anatomical Knowledge for the Infra-Pyloric Vein Preservation during the Laparoscopy-Assisted Pylorus-Preserving Gastrectomy
Authors: Nishizawa Nobuyuki , Yamashita Keishi , Shinohara Hisashi , Sakuramoto Shinichi , Hosoda Kei , Watanabe Masahiko
Published: April 2016

Background: Fine anatomical knowledge enables us to use safer laparoscopy-assisted pylorus-preserving gastrectomy (LAPPG). Detailed anatomical knowledge of the infra-pyloric vein (IPV) remains obscure. In this study, the aim was to classify the IPV vessel flow. Methods: From April 2009 to November 2012, 43 patients with clinical T1 gastric cancer underwent LAPPG with preservation of IPV. Operative videos were retrospectively reviewed, and an anatomical classification of IPV was proposed. Results: The IPV flow came into the right gastro-epiploic vein (RGEV) and/or the anterior superior pancreaticoduodenal vein (ASPDV). The IPV anatomical flow pattern was classified according to the following 4 types: Type I, the IPV more than 2 flow into RGEV; Type IIa, only 1 IPV into RGEV without into ASPDV; Type IIb, one IPV flow into RGEV and one flow into ASPDV; Type III, IPV only into ASPDV. The proportion of each type was 39.5% (17/43) in Type I, 30.2% (13/43) in Type IIa, 14% (6/43) in Type IIb, and 16.3% (7/43) in Type III. Conclusions: The anatomical flow pattern of the IPV was described. It would be beneficial to improve the anatomical knowledge of the IPV for more elaborate and safer lymph node dissection during laparoscopic gastrectomy.
Circulating Galectin-3 Levels Are Increased in Patients with Ischemic Heart Disease, but Are Not Influenced by Acute Myocardial Infarction
Authors: Singsaas Erlend G. , Manhenke Cord A. , Dickstein Kenneth , Orn Stein
Published: April 2016

Objectives: Galectin-3 (Gal-3) is involved in cardiac inflammation and fibrosis, and is in use as a biomarker that indicates increased risk in heart failure. This study examined the relationship between Gal-3 levels and acute and old myocardial infarction (MI) in patients assessed by cardiac magnetic resonance (CMR) imaging. Methods: Group 1 consisted of 38 patients with ST-elevation MI and single-vessel disease treated with primary percutaneous coronary intervention (PCI). Group 2 consisted of 52 patients with prior complicated MI. Twenty-two controls were included. CMR was performed in group 1 at 2 days, 1 week, 2 months and 1 year following PCI and in group 2 at >4 years after MI. Results: Median Gal-3 was elevated in patients compared with controls, group 1: 11.93 ng/ml (IQR 6.34-17.52, p = 0.03), group 2: 12.96 (IQR 6.33-19.29, p = 0.03) and controls: 10.16 (IQR 5.59-14.73). Gal-3 levels did not change during acute MI, and there was no relationship between Gal-3 and infarct size, troponin-T, high-sensitivity C-reactive protein, left-ventricular (LV) volumes or LV ejection fraction (LVEF) in group 1. In group 2, Gal-3 correlated modestly with MI size (r = 0.28, p < 0.05), LV end-diastolic volume index (r = 0.40, p < 0.01), LV end-systolic volume index (r = 0.43, p < 0.01) and LVEF (r = -0.39, p < 0.01). Conclusion: There was no relationship between Gal-3 levels and acute ischemic myocardial injury. A significant, modest relationship between Gal-3 levels, MI size and LV remodeling was only found in patients with old MI.
The Role of Blue Dye in Sentinel Node Detection for Breast Cancer: A Retrospective Study of 203 Patients
Authors: Garbay Jean-Remi , Skalli-Chrisostome Dounia , Leymarie Nicolas , Sarfati Benjamin , Rimareix Francoise , Mazouni Chafika
Published: April 2016

Objective: We aimed at examining the potential benefits of blue dye in sentinel node biopsy (SNB) in comparison with its proven drawbacks. Patients and Methods: In 2007, 203 T1 primary breast carcinomas had been operated on in our institute. The patients had undergone a lumpectomy and SNB. Sentinel node (SN) detection was exclusively isotopic (ISO) in 77 patients and performed with blue dye combined with a radioactive isotope (COMBI) in 126 patients. We compared the number of SNs and the rate of SN positivity in both groups. Results: The detection rate was 99% in both groups: 76/77 in the ISO group and 125/126 in the COMBI group. The mean number of SNs was 2.14 and 1.91 in the ISO group and the COMBI group, respectively (difference not significant (NS)). SN positivity was found in 26.1% and 24.6% in the ISO group and the COMBI group, respectively (NS). Only 1 SN had been removed in 26% of the patients in the ISO group versus 45.2% of the patients in the COMBI group (p = 0.004). No significant differences were observed in the tumor characteristics. Conclusion: The systematic use of patent blue dye combined with isotopic detection does not appear to increase the overall performance of the SNB technique in this retrospective study.
Expression Levels of Human Equilibrative Nucleoside Transporter 1 and Deoxycytidine Kinase Enzyme as Prognostic Factors in Patients with Acute Myeloid Leukemia Treated with Cytarabine
Authors: Candelaria Myrna , Corrales-Alfaro Carmen , Gutiérrez-Hernández Olga , Díaz-Chavez José , Labardini-Méndez Juan , Vidal-Millán Silvia , Herrera Luis A.
Published: April 2016

Background: Cytarabine (Ara-C) is the primary drug in different treatment schemas for acute myeloid leukemia (AML) and requires the human equilibrative nucleoside transporter (hENT1) to enter cells. The deoxycytidine kinase (dCK) enzyme limits its activation rate. Therefore, decreased expression levels of these genes may influence the response rate to this drug. Methods: AML patients without previous treatment were enrolled. The expression of hENT1 and dCK genes was analyzed using RT-PCR. Clinical parameters were registered. All patients received Ara-C + doxorubicin as an induction regimen (7 + 3 schema). Descriptive statistics were used to analyze data. Uni- and multivariate analyses were performed to determine factors that influenced response and survival. Results: Twenty-eight patients were included from January 2011 until December 2012. Median age was 36.5 years. All patients had an adequate performance status (43% with ECOG 1 and 57% with ECOG 2). Cytogenetic risk was considered unfavorable in 54% of the patients. Complete response was achieved in 53.8%. Cox regression analysis showed that a higher hENT1 expression level was the only factor that influenced response and survival. Conclusions: These results highly suggest that the pharmacogenetic analyses of Ara-C influx may be decisive in AML patients.
Improved (4 Plus 2) Rituximab Protocol for Severe Cases of Mixed Cryoglobulinemia: A 6-Year Observational Study
Authors: Roccatello Dario , Sciascia Savino , Baldovino Simone , Rossi Daniela , Alpa Mirella , Naretto Carla , Di Simone Debora , Menegatti Elisa
Published: April 2016

Background: In a prospective, single-center open study, we evaluated the very long-term effects of rituximab (RTX) administered to patients with severe mixed cryoglobulinemia (MC). Methods: RTX was administered to 31 patients with MC (type II in 29 cases and type III in 2) with diffuse membranoproliferative glomerulonephritis (16 cases), peripheral neuropathy (26) and large skin ulcers (7). All but 4 patients had serum anti-hepatitis C virus antibodies. RTX was administered at a dose of 375 mg/m2, according to a ‘4 + 2' protocol (days 1, 8, 15 and 22 plus 1 dose 1 and 2 months later). No other immunosuppressive drugs were added. Response was evaluated over a very long-term follow-up (mean 72.47 months, range 30-148). Results: Complete remission of pretreatment active manifestations was observed in all cases of purpuric lesions and non-healing vasculitic ulcers, and in 80% of the peripheral neuropathies. Cryoglobulinemic nephropathy significantly improved during follow-up, starting from the 2nd month after RTX (serum creatinine from 2.1 ± 1.7 to 1.5 ± 1.6 mg/dl, p ≤ 0.05; 24-hour proteinuria from 2.3 ± 2.1 to 0.9 ± 1.9 g/24 h, p ≤ 0.05). Improvement of cryoglobulinemic serological hallmarks, such as cryocrit and low complement C4, were observed. No clinically relevant side effects were recorded. Re-induction with RTX was carried out in 9 relapsed patients after a mean of 31.1 months (12-54), again with beneficial effects. The survival rate was 75% at 6 years and the probability of remaining symptom-free for 10 years without any therapy was of about 60% after a single ‘4 + 2' infusion cycle, while the probability of living symptom-free 5 years after relapsing was 80% if given the same treatment. Conclusion: In this open, prospective study, RTX appeared to be very effective and safe in the treatment of the most severe cases of MC.
Differential Expression of Stem Cell Markers in Human Adamantinomatous Craniopharyngioma and Pituitary Adenoma
Authors: Chang Claudia Veiga , Araujo Ricardo Vieira , Cirqueira Cinthya Santos , Cani Carolina Maria Gomes , Matushita Hamilton , Cescato Valter Angelo Sperling , Fragoso Maria Candida Barisson Villares , Bronstein Marcello Delano , Zerbini Maria Claudia Nogueira , Mendonca Berenice Bilharinho , Carvalho Luciani Renata
Published: April 2016

Background/Aims: Although craniopharyngioma (CP) is histologically benign, it is a pituitary tumour that grows rapidly and often recurs. Adamantinomatous CP (ACP) was associated with an activating mutation in β-catenin, and it has been postulated that pituitary stem cells might play a role in oncogenesis in human ACP. Stem cells have also been identified in pituitary adenoma. Our aim was to characterize the expression pattern of ABCG2, CD44, DLL4, NANOG, NOTCH2, POU5F1/OCT4, SOX2, and SOX9 stem cell markers in human ACP and pituitary adenoma. Methods and Results: We studied 33 patients (9 ACP and 24 adenoma) using real-time quantitative PCR (RT-qPCR) and immunohistochemistry. SOX9 was up-regulated in ACP, exhibiting positive immunostaining in the epithelium and stroma, with the highest expression in patients with recurrence. CD44 was overexpressed in ACP as confirmed by immunohistochemistry. SOX2 did not significantly differ among the tumour types. The RT-qPCR array showed an increased expression of MKI67,OCT4/POU5F1, and DLL4 in all tumours. NANOG was decreased in ACP. ABCG2 was down-regulated in most of the tumours. NOTCH2 was significantly decreased in the adenomas. Conclusion: Our results confirm the presence of stem cell markers in human pituitary tumours as well as the different expression patterns of ACP and adenoma. These findings suggest that ACP may originate from a more undifferentiated cell cluster. Additionally, SOX9 immunodetection in the stroma and the highest expression levels related to the relapse of patients suggest a contribution to the aggressive behaviour and high recurrence of this tumour type.
Clinical Development of the E75 Vaccine in Breast Cancer
Authors: Clifton Guy T. , Gall Victor , Peoples George E. , Mittendorf Elizabeth A.
Published: April 2016

E75 is an immunogenic peptide derived from the human epidermal growth factor receptor 2 (HER2) protein. A large amount of preclinical work evaluated the immunogenicity of E75, after which phase I trials investigated using E75 mixed with an immunoadjuvant as a vaccine. Those studies showed the vaccine to be safe and capable of stimulating an antigen-specific immune response. Subsequent to that, our group conducted trials evaluating E75 + granulocyte macrophage colony-stimulating factor (GM-CSF) in the adjuvant setting. The studies enrolled node-positive and high-risk node-negative breast cancer patients, with the goal being to determine if vaccination could decrease the recurrence risk. The studies included 187 evaluable patients: 108 vaccinated ones and 79 controls. The 5-year disease-free survival for the vaccinated patients was 89.7% compared to 80.2% for the control patients, a 48% reduction in relative risk of recurrence. Based on these data, E75 + GM-CSF, now known as NeuVax™, is being evaluated in a phase III trial. In this article, we review preclinical data and results of the early-phase trials and provide an update on the ongoing phase III study. We also present additional strategies for employing the vaccine to be included as a component of combination immunotherapy as well as in the setting of ductal carcinoma in situ as an initial step towards primary prevention.
Impact of Liver and Whole-Body Diffusion-Weighted MRI for Neuroendocrine Tumors on Patient Management: A Pilot Study
Authors: Moryoussef Frederick , de Mestier Louis , Belkebir Mohamed , Deguelte-Lardière Sophie , Brixi Hedia , Kianmanesh Reza , Hoeffel Christine , Cadiot Guillaume
Published: April 2016

Background: Computed tomography scan is the current standard cross-sectional imaging modality for neuroendocrine tumor (NET) workup. Diffusion-weighted magnetic resonance imaging (DW-MRI) has proven to be more sensitive than standard sequences to diagnose liver metastases; whole-body DW-MRI may be more sensitive than whole-body MRI. Clinical implications have not yet been assessed. Thus, we evaluated radiological and clinical contributions of liver and whole-body DW-MRI to manage NETs. Methods: Twenty-five abnormal liver and 22 abnormal whole-body standard MRIs were first analyzed retrospectively. MR images were then reanalyzed after adding DW sequences. The standard of reference for metastasis confirmation was a combination of radiological follow-up and histological proof. Clinical impact was defined as MRI changes of liver invasion (unilobar to bilobar and/or <50 to >50% of liver) or therapeutic management changes made during a dedicated multidisciplinary meeting after whole-body MRI. Results: Thirty-two patients with mainly small intestine NETs (24/32) were studied. Adding DW to standard liver MRI yielded additional findings for 45% of the patients with 1.78 times more new lesions, mainly infracentimetric; it induced a management change for 18% of the patients. DW sequences added to whole-body MRI yielded additional findings for 71% of the patients, with 1.72 times more lesions, mainly infracentimetric, and induced a change in management for 19% of the patients. Conclusion: Adding DW sequences to standard MRI revealed additional metastases and led to modifications of patient management. Prospective studies are needed to confirm these results.
O MANIFESTO COMO POÉTICA DA MODERNIDADE
Authors: Bortulucce Vanessa Beatriz
Published: April 2016

O presente artigo pretende realizar uma reflexão acerca do gênero manifesto, entendido como uma das formas textuais mais características da modernidade. Pretende-se analisar como o manifesto ultrapassou os limites de uma temática essencialmente política para abraçar a literatura e as artes plásticas, transformando-se em um instrumento de ação e de vivência estética tipicamente modernistas. A partir das relações entre texto, artista e público, o manifesto tornou-se o propulsor de uma nova literatura, aquela que se constitui principalmente como ação, gesto e contínuo devir.
PARTE DA SOCIEDADE OU SOCIEDADE À PARTE? REPRESENTAÇÃO DE JUDEUS NA NOVELA DIE JUDENBUCHE (1842) DE ANNETTE VON DROSTE-HÜLSHOFF
Authors: Nowinska Magdalena
Published: April 2016

Este artigo analisa Die Judenbuche, uma novela de Annette von Droste-Hülshoff, publicada em 1842. O texto, compreendido pela autora como uma representação de costumes e moralidades de uma sociedade, retrata também personagens judaicos. Neste artigo, analiso a forma como os judeus são representados: como parte da sociedade ou como uma sociedade à parte.
Gene Therapy for Coagulation Disorders
Authors: Swystun Laura L. , Lillicrap David
Published: April 2016

Molecular genetic details of the human coagulation system were among the first successes of the genetic revolution in the 1980s. This information led to new molecular diagnostic strategies for inherited disorders of hemostasis and the development of recombinant clotting factors for the treatment of the common inherited bleeding disorders. A longer term goal of this knowledge has been the establishment of gene transfer to provide continuing access to missing or defective hemostatic proteins. Because of the relative infrequency of inherited coagulation factor disorders and the availability of safe and effective alternative means of management, the application of gene therapy for these conditions has been slow to realize clinical application. Nevertheless, the tools for effective and safe gene transfer are now much improved, and we have started to see examples of clinical gene therapy successes. Leading the way has been the use of adeno-associated virus–based strategies for factor IX gene transfer in hemophilia B. Several small phase 1/2 clinical studies using this approach have shown prolonged expression of therapeutically beneficial levels of factor IX. Nevertheless, before the application of gene therapy for coagulation disorders becomes widespread, several obstacles need to be overcome. Immunologic responses to the vector and transgenic protein need to be mitigated, and production strategies for clinical grade vectors require enhancements. There is little doubt that with the development of more efficient and facile strategies for genome editing and the application of other nucleic acid–based approaches to influence the coagulation system, the future of genetic therapies for hemostasis is bright.
Evolving Treatments for Arterial and Venous Thrombosis
Authors: Chan Noel C. , Eikelboom John W. , Weitz Jeffrey I.
Published: April 2016

The direct oral anticoagulants (DOACs) represent a major advance in oral anticoagulant therapy and have replaced the vitamin K antagonists as the preferred treatment for many indications. By simplifying long-term anticoagulant therapy and improving its safety, the DOACs have the potential to reduce the global burden of thrombosis. Postmarketing studies suggest that the favorable results achieved with DOACs in the randomized controlled trials can be readily translated into practice, but highlight the need for appropriate patient, drug and dose selection, and careful follow-up. Leveraging on their success to date, ongoing studies are assessing the utility of DOACs for the prevention of thrombosis in patients with embolic stroke of unknown source, heart failure, coronary artery disease, peripheral artery disease, antiphospholipid syndrome, and cancer. The purpose of this article is to (1) review the pharmacology of the DOACs, (2) describe the advantages of the DOACs over vitamin K antagonists, (3) summarize the experience with the DOACs in established indications, (4) highlight current challenges and limitations, (5) highlight potential new indications; and (6) identify future directions for anticoagulant therapy.
Quality-of-Life Outcomes With Anatomic Versus Functional Diagnostic Testing Strategies in Symptomatic Patients With Suspected Coronary Artery Disease
Authors: Mark Daniel B. , Anstrom Kevin J. , Sheng Shubin , Baloch Khaula N. , Daniels Melanie R. , Hoffmann Udo , Patel Manesh R. , Cooper Lawton S. , Lee Kerry L. , Douglas Pamela S.
Published: April 2016

Background—

The Prospective Multicenter Imaging Study for Evaluation of Chest Pain (PROMISE) trial found that initial use of ≥64 detector-row computed tomography angiography versus standard functional testing strategies (exercise ECG, stress nuclear methods, or stress echocardiography) did not improve clinical outcomes in 10 003 stable symptomatic patients with suspected coronary artery disease requiring noninvasive testing. Symptom burden and quality of life (QOL) were major secondary outcomes.

Methods and Results—

We prospectively collected a battery of QOL instruments in 5985 patients at baseline and 6, 12, and 24 months postrandomization. The prespecified primary QOL measures were the Duke Activity Status Index and the Seattle Angina Questionnaire frequency and QOL scales. All comparisons were made as randomized. Baseline variables were well balanced in the 2982 patients randomly assigned to computed tomography angiography testing and the 3003 patients randomly assigned to functional testing. The Duke Activity Status Index improved substantially in both groups over the first 6 months following testing, but we found no evidence for a strategy-related difference (mean difference [anatomic – functional] at 24 months of follow-up, 0.1 [95% confidence interval, –0.9 to 1.1]). Similar results were seen for the Seattle Angina Questionnaire frequency scale (mean difference at 24 months, –0.2; 95% confidence interval, –0.8 to 0.4) and QOL scale (mean difference at 24 months, –0.2; 95% confidence interval, –1.3 to 0.9). None of the secondary QOL measures showed a consistent strategy-related difference.

Conclusions—

In symptomatic patients with suspected coronary artery disease who required noninvasive testing, symptoms and QOL improved significantly. However, a strategy of initial anatomic testing, in comparison with functional testing, did not provide an incremental benefit for QOL over 2 years of follow-up.

Clinical Trial Registration—

URL:
http://www.clinicaltrials.gov
. Unique identifier: NCT01174550.
On the Very Possibility of Historiography
Authors: Boulter Stephen
Published: April 2016

The familiar challenges to historiographical knowledge turn on epistemological concerns having to do with the unobservability of historical events, or with the problem of establishing a sufficiently strong inferential connection between evidence and the historiographical claim one wishes to convert from a true belief into knowledge. This paper argues that these challenges miss a deeper problem, viz., the lack of obvious truth-makers for historiographical claims. The metaphysical challenge to historiography is that reality does not appear to co-operate in our cognitive endeavours by providing truth-makers for claims about historical entities and events. Setting out this less familiar, but more fundamental, challenge to the very possibility of historiography is the first aim of this paper. The various ways in which this challenge might be met are then set out, including ontologically inflationary appeals to abstract objects of various kinds, or to “block” theories of time. The paper closes with the articulation of an ontologically parsimonious solution to the metaphysical challenge to historiography. The cost of this approach is a revision to standard theories of truth. The central claim here is that the standard theories of truth have mistaken distinct causes of truth for truth itself. This mistake leads to distorted expectations regarding truth-makers for historiographical claims. The truth-makers of historiographical claims are not so much the historical events themselves (for they do not exist) but atemporal modal facts about the order of things of which those events were a part.
Ratification as accommodation? Domestic dissent and human rights treaties
Authors: Ryckman Kirssa Cline
Published: April 2016

Repression is the expected response to anti-government protest; however, leaders can also accommodate demonstrators. Committing to human rights treaties is considered in this environment, where treaty commitments are conceptualized as a policy concession that leaders can grant dissenters. Past research has shown that top-down domestic pressures, such as new democratic regimes, can influence treaty commitments. This article extends this line of research by considering the influence of bottom-up domestic pressure, arguing that nonviolent, pro-democracy movements can pressure leaders into concessions, as these movements are risky to repress but threatening to ignore. Leaders are expected to seek ‘cheap’ accommodations, and commitments to human rights treaties provide a relatively low-cost concession that also addresses demonstrators’ pro-democracy demands. Using commitments to the nine core UN human rights treaties, results are generally supportive. Governments experiencing a nonviolent, pro-democracy movement are consistently likely to sign human rights treaties. Ratification is also likely but in more limited contexts, and is more closely related to movement success. This suggests that bottom-up pressures can influence commitment to human rights treaties, but there may be little substance behind those concessions. The status quo and cost-averse preferences of leaders lead them to grant accommodations that result in minimal change and cost.
Subjective Social Status and Adolescent Health
Authors: Huynh Virginia W. , Chiang Jessica J.
Published: April 2016

Despite adolescence being a period marked by significant social changes, research on social status focuses largely on adults. This study examined whether school and societal subjective social status (SSS) are differentially associated with adolescent health above and beyond objective socioeconomic status (SES), and explored pathways linking SSS to health. Latino ( n = 169) and Asian American ( n = 77) adolescents ( M age = 17.23, SD = 0.74; 59% female) completed self-reports of SSS, sleep, stress, and somatic symptoms. Parents reported income and education. Blood pressure (BP) measurements were obtained. Results indicate that independent of objective SES, lower school SSS was associated with higher diastolic BP whereas lower societal SSS was associated with more somatic symptoms. Sleep disruptions and perceived stress mediated the association between societal SSS and somatic symptoms. Results suggest that SSS may be more important to adolescent health than objective SES. Furthermore, school and societal SSS may differentially affect indicators of health through different pathways.
Book Review: K. C. Sivaramakrishnan, Governance of Megacities—Fractured Thinking, Fragmented Setup
Authors: Fatima Sheema
Published: April 2016

K. C. Sivaramakrishnan, Governance of Megacities—Fractured Thinking, Fragmented Setup, New Delhi, Oxford University Press, 2014, 372 pp., ₹895, ISBN 978-01-99454-13-6.
Thinking globally, acting locally? The women’s sector, international human rights mechanisms and politics in Northern Ireland
Authors: Thomson Jennifer
Published: April 2016

Literature considering international human rights mechanisms stresses that they have the best chance of success when they are closest to ideas which already exist within national contexts. Research which addresses women’s human rights bodies, such as the Convention Against All Forms of Discrimination Against Women (CEDAW) and United Nations Security Council Resolution 1325 (UNSCR 1325), argues that they function best when reinterpreted to fit the local context. Yet, situations where this domestic norm translation is occurring, but policy change is not achieved, have received little consideration. Why do some contexts, even where norm translation occurs, resist policy change? This article examines Northern Ireland, where these women’s rights bodies are used extensively in the women’s sector, but where change has not occurred. It argues that norm translation is not the only important factor, and that a greater consideration of local political structures is needed in order to more fully explain policy resistance.
Bourdieu’s non-material forms of capital: Implications for start-up policy
Authors: Lee Robert , Shaw Eleanor
Published: April 2016

The role of Bourdieu’s non-material forms of capital (cultural, social and symbolic) in the entrepreneurial process has received little dedicated research attention. Similarly, the link between occupationally distinct entrepreneurship and accumulation of non-material capitals is understudied. Addressing this, we examine the non-material capitals of different nascent entrepreneurs by occupational classification who participated on two enterprise-training programmes funded by the 1997–2010 Labour Government; each with considerably different foci. Findings demonstrate that professional and higher technician entrepreneurs possess valuable non-material capitals, in contrast to non-professional entrepreneurs. Against the backdrop of recent business enterprise policy, findings suggest that policy-makers should prioritise focused support that nurtures the valuable, productive non-material capitals of professional and higher technician entrepreneurs. Furthermore, initiatives should be tailored to improve the less distinguished non-material capitals of non-professional entrepreneurs.
Role of psychological factors in burning mouth syndrome: A systematic review and meta-analysis
Authors: Galli Federica , Lodi Giovanni , Sardella Andrea , Vegni Elena
Published: April 2016

Background

Burning mouth syndrome (BMS) is a chronic medical condition characterised by hot, painful sensations in the lips, oral mucosa, and/or tongue mucosa. On examination, these appear healthy, and organic causes for the pain cannot be found. Several studies have yielded scant evidence of the involvement of psychological and/or psychopathological factors, and several have outlined a model for the classification of BMS.

Aim

This review aims to provide a systematic review of research examining the psychological, psychiatric, and/or personality factors linked to BMS.

Findings

Fourteen controlled studies conducted between 2000 and the present were selected based on stringent inclusion/exclusion criteria. All studies but one reported at least some evidence for the involvement of psychological factors in BMS. Anxiety and depression were the most common and the most frequently studied psychopathological disorders among BMS patients.

Discussion and conclusion

Anxiety and depression play critical roles in this condition. Evidence on the role of personality characteristics of BMS patients has also been produced by a few studies. Further studies on the role of specific psychological factors in BMS are warranted, but the importance of a multidisciplinary approach (medical and psychological) to BMS is no matter of discussion.
A Multifaceted Approach to Revitalizing the Baby-Friendly Hospital Initiative in Croatia
Authors: Grgurić Josip , Zakarija-Grković Irena , Pavičić Bošnjak Anita , Stanojević Milan
Published: April 2016

The Baby-Friendly Hospital Initiative (BFHI) was launched in Croatia in 1993. By 1998, 15 of 34 maternity facilities were designated “Baby-Friendly.” Introduction of hospital bags, violating the International Code of the Marketing of Breastmilk Substitutes, led to a standstill in the BFHI. The aim of this article is to describe the successful reintroduction of the BFHI in Croatia between 2007 and 2015. After hospital bags were abolished in 2007, UNICEF Croatia undertook an assessment of BFHI implementation. All maternity facilities were invited by UNICEF and the Ministry of Health to join the renewed BFHI. UNICEF materials were translated and training for trainers, assessors, coordinators, and hospital staff held. By June 2015, 30 of 32 (94%) maternity facilities, providing care to 89% of newborns, were Baby-Friendly. Nine maternity hospitals have been renovated and 2 new hospitals have been built. Exclusive breastfeeding rates have risen 16% at 0 to 2 months (from 51% in 2007 to 67% in 2014) and 14% at 3 to 5 months (from 32% in 2007 to 46% in 2014). Fourteen “Breastfeeding-Friendly” primary care practices have been designated, 166 breastfeeding support groups are in operation, criteria for Mother-Friendly care are being piloted in 2 maternity facilities, and “Ten Steps in the Neonatal Intensive Care Unit” are being introduced. The BFHI provides an excellent opportunity for revitalizing breastfeeding protection, promotion, and support in all settings. Recognition and support of the BFHI by the Croatian government was crucial for implementing the BFHI, whereas the marketing practices of the breast milk substitutes industry are an ongoing challenge.
Comparison of Two Heated Gutta Percha and Sealer Obturation Techniques in Canine Teeth of Dogs
Authors: Mendoza Krista A. , Marretta Sandra Manfra , Siegel Arthur M. , Stapleton Barbara L. , Wiggs Robert B. , Klippert Linda S.
Published: April 2016

The overall endodontic fill and apical seal achieved using two different obturation methods were compared. Twenty-six adult dog canine teeth were instrumented and obturated using either a warm vertical or heated lateral technique. Zinc oxide-eugenol sealer was applied by paper point in the warm vertical technique and by syringe injection in the heated lateral technique. The cadaver jaws were warmed to 35–37°C (95–98.6°F) during obturation using a circulating warm water bath. Obturation times were recorded and ventrodorsal, lateral, and oblique dental radiographs were taken of all teeth for comparison. Twenty-two of the canine teeth were extracted and an apical dye study was performed using a clearing technique. Apical dye leakage was linearly measured to evaluate the furthest ink penetration into the root canal. Although radiographically the heated lateral method appeared to have a better endodontic fill, there was significantly greater apical dye leakage in teeth obturated with that combination of sealer and gutta percha. There was also extrusion of sealer and root fracture associated with the heated lateral technique. The method of sealer application was different for each technique; this variable should be taken into consideration when interpreting our results, which suggest that the warm vertical compaction technique may provide a better apical seal in canine teeth of dogs in a shorter period of time, with fewer obturation complications when compared to the heated lateral technique.
Oral and Maxillofacial Reconstruction in a Cat Using Wire and Acrylic
Authors: Barbudo Glenda R. , Selmi Andre L. , Canola Julio C.
Published: April 2016

A 15-month-old DSH cat was presented with facial deformity secondary to multiple oral and maxillofacial fractures after being struck by an automobile. Multiple wires and dental acrylics were used for fracture repair.
Treatment of Mandibular First Molar Teeth with Endodontic-Periodontal Lesions in a Dog
Authors: Niemiec Brook A.
Published: April 2016

A two-year-old spayed/female Miniature Pinscher was treated for mobility of the left and right mandibular first molar teeth. Periodontal probing and intraoral dental radiographs indicated severe periodontal attachment loss. It was determined that both teeth had endodontic-periodontal lesions based on restoration of periodontal attachment and partial resolution of radiolucent periapical lesions following treatment which emphasized endodontic therapy.
Clinical and Microbiological Effects of Oral Zinc Ascorbate Gel in Cats
Authors: Clarke David E.
Published: April 2016

The clinical and microbiological effects of zinc ascorbate gel applied orally in cats were evaluated during a 42-day study period. Cats were divided randomly into two equal groups, with the treatment group (18 cats) receiving zinc ascorbate gel and the control group (18 cats) receiving a placebo (0.9 % sterile saline). Clinical parameters evaluated biweekly included halitosis, plaque, calculus, and gingivitis. Aerobic and anaerobic bacterial cultures were obtained from cats in the treatment group at Days 0 and 42. There was a significant decrease in plaque, gingivitis, and anaerobic periodontal pathogens in treatment group cats. Halitosis and calculus scores were not significantly different in treatment group compared with control group cats. The results of this study suggest that zinc ascorbate gel used as an oral antiseptic improves feline oral health, and may be most effective in decreasing bacterial growth, plaque formation, and gingivitis when applied following a professional teeth cleaning procedure.
Evaluation of a Modified Hemimandibulectomy for Treatment of Oral Neoplasms in Dogs
Authors: Felizzola Cláudia Ronca , Stopiglia Angelo João , de Araújo Vera Cavalcante , de Araújo Ney Soares
Published: April 2016

A modified hemimandibulectomy was performed for treatment of oral neoplasms in 21 dogs. Intra- and postoperative evaluations included assessment of procedure difficulty, complications, mastication, cosmesis, and the time interval between surgery and recurrence of the neoplasm or clinical evidence of metastasis. Malignant melanoma was the most common neoplasm treated using this technique. The modified hemimandibulectomy was uncomplicated with minimal intraoperative hemorrhage. Three dogs had difficult mastication at 24-hours following surgery, while 5 dogs had partial wound dehiscence. Wound infection was diagnosed in 1 dog. All owners considered the postoperative outcome to provide acceptable cosmesis. Local neoplasm recurrence was documented in 5 dogs and distant (pulmonary) metastasis was diagnosed in 5 different dogs following surgery. The technical modification described in this study seemed to provide for improved mastication during the acute postoperative period compared with other hemimandibulectomy techniques performed by the authors.
Effective Periodontal Disease Control Using Dental Hygiene Chews
Authors: Brown Wendy Y. , McGenity Phil
Published: April 2016

This study evaluated the effectiveness of a newly developed dental hygiene chew for dogs, with and without a natural antimicrobial additive, compared with a reference diet. Efficacy was determined by measuring the severity of gingivitis and the accumulation of dental plaque and calculus in dogs after 4-weeks of being fed the different dietary regimens. Dogs fed a single daily dental chew had significantly less gingivitis (P = 0.02), plaque (P = 0.0004), and calculus (P = 0.0001) compared with dogs in the control group that were fed an identical diet but received no chews. The inclusion of the antimicrobial agent did not improve the efficacy of the product. The dental hygiene chews tested in this study have potential to help reduce the incidence of periodontal disease in dogs.
Dens Invaginatus of the Mandibular First Molars in a Dog
Authors: Stein Keith E. , Marretta Sandra Manfra , Eurell Jo Ann C.
Published: April 2016

A 6-year-old dog was presented for draining tracts associated with both mandibular first molar teeth. Radiographs of the affected teeth showed periapical bone lysis. Surgical tooth extractions were performed and the tooth segments were submitted for histopathologic examination. Microscopic evaluation of the teeth showed in folding of the enamel and dentin consistent with a diagnosis of dens invaginatus. Examination performed 13-months following the extraction procedures indicated uncomplicated healing at the extraction sites and no other visible evidence of endodontic disease.
Observations of the Periodontal Ligament and Cementum in Cats with Dental Resorptive Lesions
Authors: Roux P. , Berger M. , Stoffel M. , Stich H. , Doherr M.G. , Bosshard D. , Schawalder P.
Published: April 2016

The etiology of feline dental resorptive lesions is unknown, but some evidence suggests that interactions between components of the periodontium may be initiating factors in the development of these lesions. In the present study, 22 clinically normal teeth were harvested from 7 cats. The teeth and periodontium were radiographed and examined histologically. In addition, 14 of the 22 teeth were examined histometrically. Two teeth were histologically normal with an open apical foramen and two were normal with a closed apical foramen. Histological evidence of periodontal ligament degeneration without cementum resorption was observed in 8 teeth, and varying degrees of cementum resorption were observed in 10 teeth. Mandibular molar and premolar teeth had distal drift, and mandibular canine teeth had mesial drift. Alterations in the periodontal ligament may represent a preclinical stage of dental resorption.
Immunohistochemical Identification of Lymphatic Vessels in the Periodontium of Equine Cheek Teeth
Authors: Staszyk Carsten , Duesterdieck Katja F. , Gasse Hagen , Bienert Astrid
Published: April 2016

Immunohistochemical detection of lymphatic capillaries was performed in the periodontium of maxillary and mandibular cheek teeth from 6 horses (aged 3–23 years). Tissue sections of the periodontium were taken at 4 different horizontal levels along the long axis of the tooth. The specimens were processed for immunoreaction with anti-Proxl, in order to distinguish lymphatic endothelium from blood vascular endothelium. Lymphatic vessels were detected in all periodontal tissues except for the dental cementum. Lymphatic capillaries were most densely distributed in the gingiva compared to other tissues of the periodontium. Lymphatic capillaries were found most consistently in samples taken from the gingival and subgingival regions in all horses examined. Within these levels, the gingiva as well as the spongiosa of the maxillary and mandibular bone had the greatest incidence of lymphatic vessels. Considering the distinct distribution of the lymphatic capillaries in the periodontium of the maxillary and mandibular cheek teeth, two complementary lymphatic drainage pathways are proposed: (1) superficial lymph drainage via the gingiva, emptying into the mandibular lymph nodes; (2) deep lymph drainage via the mandibular and maxillary spongiosa, emptying into the mandibular and retropharyngeal lymph nodes, respectively.
Temporomandibular Joint Cytokine Profiles in the Horse
Authors: Carmalt James L. , Gordon John R. , Allen Andrew L.
Published: April 2016

It has been suggested that dental abnormalities lead to temporomandibular joint inflammation and pain that may be mitigated by regular dental care. There is considerable literature on the pathophysiology of equine joint disease including studies on cytokine profiles in diseased appendicular joints. This study examined the effects of age and dental malocclusions summarized as a dental pathology score on equine temporomandibular joint cytokine (IL-1, IL-6, IL-8, TNF α and TGF-β1, -β2, -β3) concentrations. TGF-β3 was not detected in any joint sample. IL-1, IL-6 and TNF α were not influenced by age. Foals had significantly lower concentrations of IL-8 and TGF-β1, and higher levels of TGF-β2 compared with older horses. Age did not effect cytokine concentration in older horses although there was a trend towards increasing IL-8 with age. The dental pathology score increased with age in mature horses, however there was no effect of dental pathology score on cytokine concentration. There was no effect of incisor eruption, and presence or number of periodontal lesions on temporomandibular joint cytokine concentration. Our findings indicate that age but not dental pathology affected temporomandibular joint proinflammatory cytokine concentration in this population of horses.
Periodontal Disease Burden and Pathological Changes in Organs of Dogs
Authors: Pavlica Zlatko , Petelin Milan , Juntes Polona , Eržen Damjan , Crossley David A. , Skalerič Uroŝ
Published: April 2016

Bacterial plaque associated periodontal disease is the most common chronic infection in man and dogs. In man, there is an association between periodontal disease and myocardial infarction and stroke, while in dogs it has also been associated with changes in internal organs. Inflamed periodontal tissues present a ‘periodontal disease burden’ to the host and the extent of this inflammatory disease burden is likely to affect the degree of associated pathological change in distant organs. This hypothesis was investigated in dogs with naturally occurring periodontal disease. Post-mortem investigations including periodontal assessment, standard necropsy, and organ histology were performed on 44 mature toy and miniature Poodles (related, periodontitis predisposed breeds) that died naturally or were euthanized based on clinical disease. Animals with gross primary organ pathology were excluded. The periodontal disease burden was estimated from the total surface area of periodontal pocket epithelium using six measurements of probing depth for each tooth and the tooth circumferences. Ordinal logistic regression (OR) analysis established that for each square centimeter of periodontal disease burden there was a 1.4-times higher likelihood of greater changes being present in the left atrio-ventricular valves (OR = 1.43), plus 1.2 and 1.4 times higher likelihood for greater liver and kidney pathology (OR = 1.21; OR = 1.42), respectively. The results show that there is a link between the estimated ‘periodontal disease burden’ resulting from plaque-bacteria associated periodontal disease and the level of internal pathology in this population, implying that periodontitis might contribute to the development of systemic pathology in dogs.