bluuebunny/crossref_metadata_2025 huggingface dataset:
Computer-Aided English Teaching Platform Based on Secure Shell Framework
Authors: Qiu Lingling
Published: August 2019

With the aid of information-based teaching platform, the traditional classroom English teaching mode can be improved to provide students with a realistic linguistic environment and enhance their learning interest. As a result, the web-based computer aided English teaching has become the mainstream in college English education. Based on the browser/server (B/S) structure, this paper designs a computer-aided English teaching platform of the model–view–controller (MVC) architectural pattern. The programming was carried out using the MySQL database, and the functions of the computer-aided English teaching platform were realized securely and stably by the popular Secure Shell (SSH) framework. The system test results show that the proposed platform supports the open teaching of college English, solves the lack of interaction in traditional classroom teaching, and arouses the students’ learning interest. The research further promotes the reform of college English teaching, and enriches the theories and practices on computer-aided English teaching.
English Teaching Platform Based on Online Education Technology and Licensure and Master's Program Technology
Authors: Wang Lina , Huang Ruying
Published: August 2019

This paper attempts to build a web-based English teaching platform that improves students’ efficiency in English learning. After reviewing the current theories on teaching platforms, the author combined online education technology and the Licensure and Master’s Program (LAMP) technology into a mixed teaching mode, which inherits the advantages of traditional teaching and network technologies. In addition, an English teaching platform was designed for the instruction and exercises for English courses. The platform is operated jointly by students, teachers and administrators. The research shows that the English teaching system, through the integration between information technology and LAMP, could be turned into a resource module to be used as a plug-in for online education; the proposed English teaching platform is a new-generation system for the teaching and learning of English reading, grammar, speaking and listening. The proposed platform greatly improves the teaching methods and the learning efficiency, laying a theoretical basis for the construction of the new teaching system platform.
A Flipped Classroom-Based Education System for College English Teaching
Authors: Zhang Haiyan
Published: August 2019

The flipped classroom (FC) is a novel teaching mode combining traditional class-room and computer network technology. This paper attempts to design a FC-based education system for college English teaching, which is critical to the quali-ty of English teaching in colleges. In our research, a college English education system is established based on SQL server and FC. The architecture and func-tional modules of the system were discussed in details. Specifically, the system architecture was created based on the browser/server (B/S) structure, the data management was realized by SQL server 2008, and the system functions were designed and achieved by JavaServer Pages (JSP). The proposed system was tested in an actual application. The results confirm that the system can meet the teaching demand, arouse the students’ interest in learning and improve the effect of English teaching.
Biological Activities and Dermal Penetration of Liposome-Containing Coprinus atramentraris Extract
Authors: Sobharaksha Parapat , Indranupakorn Ratana , Manchan Sonmkamol
Published: August 2019

The total phenolic content and antioxidant activities of five edible mushrooms (Pleurotus djamor, Agaricus bisporus, Hericlum erinaceus, Coprinus atramentraris and P. ostreatus) were evaluated. The Coprinus atramentraris ethanolic extract (CE) showed the promising antioxidant property and had a strong relationship with phenolic compound content. Liposome-containing CE formulations, were prepared with various lipid composition. The liposome formulation, L1, which composed of phospholipids and cholesterol at ratio of 6:4 gave the highest entrapment efficiency (24.03%), small particle size (143.03 nm) and favorable particle size distribution (0.311) with small values of zeta potential (-30.2 mV). L1 showed good anti-elastase property (IC50 0.029) and no cytotoxicity effect to the human skin fibroblasts and melanoma cells even at the highest concentration of 1 mg/mL compared to the unformulated extract. The in vitro skin permeation studies, using human cadaver skin and modified Franz-diffusion cells, showed that the L1 was able to considerably increase the rate of permeation of phenolic compounds in L1 compared to the CE solution. These results reflect the use of L1 as active agents in cosmeceuticals.
Folate-Functionalized Amphiphilic Chitosan Polymeric Micelles Containing Andrographolide Analogue (3A.1) for Colorectal Cancer
Authors: Kansom Teeratas , Dumkliang Ekachai , Patrojanasophon Prasopchai , Sajomsang Warayuth , Saeeng Rungnapha , Zhu Wei Ming , Opanasopit Praneet
Published: August 2019

A site-specific drug delivery system of anticancer agents has been delveloped to enhance the therapeutic efficacy and reduce toxicity to the normal tissue. Semi-synthetic andrographolide analogue 3A.1 (19-tert-butyldiphenylsilyl-8,17-epoxy andrographolide) is one of the potential natural anticancer compounds against many types of cancer including colorectal cancer cells. However, the clinical applications of this compound are limited because of low water solubility and lack of suitable delivery carriers. This study aimed to increase the aqueous solubility and improve the anticancer efficacy of 3A.1 via active targeting approaches. In this study, 3A.1 was loaded into the polymeric micelles self-assembled from N-naphthyl-N,O-succinyl chitosan (NSC). The micelles were conjugated with folate moiety (Fol-NSC) for targeting to the cancer cells. All of the 3A.1-loaded micelles were prepared by dropping method, and the physicochemical properties (size, charge, morphology, encapsulating efficiency, loading capacity), in vitro release behavior and in vitro anticancer activities against HT29 colorectal cancer cells were investigated. The 3A.1-loaded micelles were successfully formulated by dropping method using NSC or Fol-NSC. The micelles loaded with 40% initial 3A.1 showed the maximum encapsulating efficiency and loading capacity. The micelles were in the nanometer range, having a negative surface charge and a spherical structure. The colon site-specific release of the 3A.1 from the 3A.1-loaded micelles was obtained. The release of 3A.1 from the Fol-NSC micelles was slower than that from the NSC micelles. Moreover, the Fol-NSC micelles exhibited superior anticancer efficacy than that of the NSC micelles and free 3A.1. In conclusions, the 3A.1-loaded Fol-NSC micelles developed in the present study had suitable physicochemical properties. These nanocarriers may be a potential delivery system for targeted delivery of the 3A.1 to colorectal cancer cells.
Extraction Method of Protein and Insulin-Like Growth Factor-1 from Deer Antler Velvets for Skin Rejuvenation
Authors: Rangsimawong Worranan , Tansathien Krisanaporn , Wattanakul Apichart , Ngawhirunpat Tanasait , Opanasopit Praneet
Published: August 2019

Deer antler velvets (DAVs) contain many growth factors and protein. To extract growth factor from DAV, the suitable method and material properties have to investigate. The aim of this study was to improve the growth factor content in DAV extract for using as a skin rejuvenation compound. Different extraction methods (such as ethanol extract, probe sonication and precipitation method) and material preparations (such as fresh, dried by freeze drier and dried by hot air oven with and without gramma ray) were performed to evaluate the total protein and insulin-like growth factor-1 (IGF-1). The suitable condition was choose to determine the antioxidant activity and effect on the skin properties (such as in vitro skin permeation and in vivo human studies). For the results, fresh DAV extracted by probe sonication method provided the significantly highest total protein (586.31 + 48.17 mg/g) and IGF-1 (31.32 + 10.55 ng/g) contents. At the concentration of 2,000 μg/ml, this extract was completely dissolved in water and exhibited the antioxidant potential nearly 50% inhibition. For skin permeation at 24 h, the skin treated with DAV extract showed 3.83 + 2.04% of protein permeated through skin. The skin elasticity and hydration significantly increased after applying DAV extract for 28 days. In conclusion, the DAV extract by using fresh DAV and probe sonication method exhibited high IGF-1 and protein content as well as an antioxidant potential, leading to improve the skin properties. This extract might play an important role in the skin rejuvenation product.
Stability of Mangiferin in Lotion and its Antioxidant Activity
Authors: Jutiviboonsuk Aranya , Leeprechanon Wilaipan
Published: August 2019

The antioxidant lotion containing 1% mangiferin, which was previously isolated from leaves of mango variety Nam Doc Mai (purity 93.15%, HPTLC analysis), was prepared. The lotion was an o/w type of emulsion with slightly yellow and coconut scent. The viscosity and pH of the lotion were 19,809 centipoise and 5.94, respectively. Stability studies were performed at room temperature (25±5 °C) with 70±10%RH and at high temperature (45±2 °C) with 75%RH. The amount of mangiferin in the lotion was investigated at various time intervals by HPTLC. The results showed that mangiferin in the lotion remained 80.30±1.87%LA after storage for 3 months at room temperature. While it remained less than 80%LA after storage for 2 weeks at high temperature and only 38.51±0.35%LA remained after 3 months of storage. An unknown degradant was detected at theRfvalue of 0.24. It was produced increasingly when storage peroid taken longer, especially at the high temperature. UV spectra of the degradant and mangiferin suggested the similarity of their chemical structures. Antioxidant activity of the lotion was evaluated by DPPH radical scavenging method. Interestingly, the activity has not decreased at both temperatures during storage times even if mangiferin degraded. It was possible that the degradant could scavenge DPPH redical and chemical structure of the degradant might be xanthone.
Il principio di prudenza terapeutica. Oltre le distinzioni ordinario-straordinario e proporzionato-sproporzionato
Authors: Requena Meana Pablo
Published: August 2019

La questione sull’obbligo di impiegare o di non impiegare un mezzo terapeutico, era tradizionalmente risolta definendo obbligatori i mezzi che si consideravano ordinari, e invece non obbligatori quelli che si consideravano straordinari. Dopo le critiche ricevute da questo tentativo di risposta si è provato a risolvere diversamente la questione suddividendo le opzioni terapeutiche in proporzionate e sproporzionate. In questo articolo si tenta di mostrare come le due distinzioni non siano equivalenti e come, anche se necessarie, non siano sufficienti per il buon agire medico. Si deve pertanto sempre ricorrere alla prudenza terapeutica per fornire ad ogni paziente la migliore opzione medica personalizzata.
COMPARISON OF PRESEPSIN, PROCALCITONIN, INTERLEUKIN-8 AND C-REACTIVE PROTEIN IN PREDICTING BACTERAEMIA IN FEBRILE NEUTROPENIC ADULT PATIENTS WITH HAEMATOLOGICAL MALIGNANCIES
Authors: Kostic Irena , Gurrieri Carmela , Piva Elisa , Semenzato Gianpietro , Plebani Mario , Caputo Ilaria , Vianello Fabrizio
Published: August 2019

Bacterial infections represent life-threatening complications in patients with febrile neutropenia (FN). Biomarkers of infections may help to differentiate bacteraemia from non-bacteraemia FN. We aimed to evaluate the utility of procalcitonin (PCT), presepsin (PS), C-reactive protein (CRP) and interleukin-8 (IL-8) as biomarkers of bacteraemia in adult FN patients with haematological malignancies. Thirty-six FN episodes experienced by 28 oncohematological patients were considered. 11 out of 36 episodes were classified as bacteraemia. PCT was the best biomarker to predict bacteraemia with area under the curve (AUC) ROC of 0,9; while the most sensitive was IL-8 (90,9%) with AUC ROC of 0,88. All patients with PCT concentrations above 1,6 μg/l had bacteraemia. Patients with IL-8 concentrations > 170 pg/ml or PS concentrations superior then 410 pg/ml had 40 times and 24 times higher risk for bacteraemia, respectively. PCT remains better than IL-8 and PS in predicting bacteraemia in adult hematological patients with FN.
CMV MANAGEMENT WITH SPECIFIC IMMUNOGLOBULINS: A MULTICENTRIC RETROSPECTIVE ANALYSIS ON 92 ALLOTRANSPLANTED PATIENTS.
Authors: Malagola Michele , Greco Raffaella , Santarone Stella , Iori Anna Paola , Quatrocchi Luisa , Barberi Walter , Antonella Bruzzese , Leotta Salvatore , Carotti Alessandra , Pierini Antonio , Bernardi Simon , Morello Enrico , Polverelli Nicola , Turra Alessandro , Cattina Federica , Gandolfi Lisa , Rambaldi Benedetta , Lorentino Francesca , Serio Francesca , Natale Annalisa , Milone Giuseppe , Velardi Andrea , Foà Robin , Ciceri Fabio , Russo Domenico , Peccatori Jacopo
Published: August 2019

CMV represents one of the most serious life-threatening complications of allogeneic stem cell transplantaion (allo-SCT). Pre-emptive treatment is highly effective, but toxicity and repetitive reactivation of CMV represent a major challenge in the clinical practice. The use of anti-CMV specific immunoglobulins (Megalotect) is controversial.

We retrospectively collected data on 92 patients submitted to allo-SCT for hematological malignancies, in whom Megalotect was used either for prophylaxis (n=14) or with pre-emptive therapy (n=78). All the patients were considered at high-risk of developing CMV reactivation and CMV disease.

The treatment was well tolerated, with no reported infusion reactions, nor other adverse events. None of the 14 cases treated with Megalotect as prophylaxis developed CMV reactivation. 51/78 (65%) patients who received Megalotect during pre-emptive treatment achieved complete clearance of CMV viremia, and 14/51 patients (29%) developed a breakthroug CMV infection. 7/78 patients (9%) developed CMV disease. The projected 1-year OS, 1-year TRM and 1-year RR is 74%, 15% and 19%, respectively. No differences were observed in terms of OS, TRM and RR by comparing patients who achieved a complete response after treatment versus those who did not..

These retrospective data suggest that Megalotect is safe and well tolerated. When used as prophylaxis, no CMV reactivation was recorded. We have no conclusive data regarding its efficacy in reducing the cumulative dose of anti-CMV specific drugs in the pre-emptive setting. Further prospective trials are warrented to identify the best setting of patients who can benefit from Megalotect alone or in addition to anti-CMV specific drugs.
Assessment of cabin crew awareness about malaria in a major airline
Authors: Albayat Soha Shawqi , Kokku Suresh B , Al-Romaihi Hamad Eid , Bansal Devendra , Khogali Hayat Salahaldin , Farag Elmoubasher
Published: August 2019

Background
Malaria is a global public health problem across Africa, Asia and Americas. In the recent past, a dramatic increase in global air travel networks and connectivity contributed to increased risk of contracting malaria. Airline cabin crew travelling to malaria high-risk countries are at increased risk of contracting the disease. Awareness plays an important role in prevention of malaria among the crew by having high degree of knowledge of disease and adhering to the protective measures advised. In this study we aimed to evaluate the knowledge about malaria, risk assessment, prevention and prophylaxis of malaria among a major commercial airline crew member.
Methods
This was qualitative cross-sectional study based on structured questionnaire conducted among crew members in a major commercial airline. We have deployed purposive sampling to pick 40 crew members who frequently travel to malaria endemic areas as part of their duty. The questionnaire contained both close and open-ended questions, which was given to the participants via the receptionists at the medical centre of the airline.
Results
Most of the cabin crew members were aware about malaria and its causes, symptoms, prevention and effective treatment. Many of the participants have been taking necessary precautions to ensure that they are safe but not all possible measures.
Conclusions
The baseline data should be further confirmed to assist in giving the appropriate recommendations to help combat the issue of protecting cabin crews from the risks of Malaria.
PREGNANCY LOSS IN WOMEN WITH HIV IS NOT ASSOCIATED WITH HIV MARKERS: DATA FROM A NATIONAL STUDY IN ITALY, 2001-2018
Authors: Floridia Marco , Masuelli Giulia , Tassis Beatrice , Tamburrini Enrica , Savasi Valeria , Sansone Matilde , Spinillo Arsenio , Liuzzi Giuseppina , Degli Antoni Anna , Dalzero Serena , Franceschetti Laura , Simonazzi Giuliana , Maso Gianpaolo , Francisci Daniela , Pinnetti Carmela , Ravizza Marina
Published: August 2019

Background: There is limited information on pregnancy loss in women with HIV, and it is still debate whether HIV-related markers may play a role.

Objectives: To explore potential risk factors for pregnancy loss in women with HIV, with particular reference to modifiable risk factors and markers of HIV disease.

Methods: Multicenter observational study of HIV-positive pregnant women. The main outcome measure was pregnancy loss, including both miscarriage (<22 weeks) and stillbirth (≥22 weeks). Possible associations of pregnancy loss were evaluated in univariate and multivariate analyses.

Results: Among 2696 eligible pregnancies reported between 2001 and 2018, 226 (8.4%) ended in pregnancy loss (miscarriage 198, 7.3%; stillbirth 28, 1.0%). In multivariate analyses, only older age (adjusted odds ratio [AOR] per additional year of age: 1.079, 95% confidence interval [CI] 1.046.1.113), HIV diagnosis before pregnancy (AOR: 2.533, 95%CI 1.407-4.561) and history of pregnancy loss (AOR: 1.625, 95%CI 1.178-2.243) were significantly associated with pregnancy loss. No significant association with pregnancy loss was found for parity, coinfections, sexually transmitted diseases, hypertension, smoking, alcohol and substance use, CD4 cell count, HIV-RNA viral load and CDC HIV stage.

Conclusions: Older women and those with a previous history of pregnancy loss should be considered at higher risk of pregnancy loss. The severity of HIV disease and potentially modifiable risk factors apparently did not increase the risk of pregnancy loss.
PLATELET TO LYMPHOCYTE RATIO IN NEONATES: A PREDICTOR OF EARLY ONSET NEONATAL SEPSIS
Authors: Karabulut Birol , Arcagok Baran Cengiz
Published: August 2019

Introduction

Neonatal sepsis (NS) is a common systemic disease that causes morbidity and mortality in newborns. But there is no ideal biomarker that can be used in the early diagnosis of NS. In recent studies, platelet width to lymphocyte ratio (PLR)  have been reported to play a critical role in the inflammatory process. In this study, we aimed to contribute to the research about whether or not PLR can be used in the early diagnosis of NS.

Methods

This retrospective cohort study was conducted among the newborns whose born in İzmir Buca Maternity and Pediatric Hospital between March 2015-February 2016. During these twelve months, 611 neonates with EOS were admitted to our neonatal intensive care unit. One hundred and forty-nine neonates with  suspected EOS, 67 neonates with proven EOS and 92 healty neonates were enrolled in the study.

Results

Platelet width lymphocyte (LPR) values of the groups were calculated 56.5 ± 17.8 vs 62.4± 14.9 vs 15.3 ± 2.1 respectively. PLR values of suspected or proven EOS group was significantly higher than the control group. PLR has AUC 0.89 to 0.93, cutoff value of 39.5 to 57.7, sensitivity of 88.9% to 91.3% and specifity of 94.7% to 97.6%, positive predictive value of 94.3% to 97.4%, and negative predictive value of 88.6% to 91.8% in suspected and proven sepsis diagnosis.

Conclusion

Based on our results suggest that PLR can be used as a biomarker predictive of EOS.
AGING WITH HEMOPHILIA: THE CHALLENGE OF APPROPRIATE DRUG PRESCRIPTION
Authors: Mannucci Pier Mannuccio
Published: August 2019

In high-income countries persons with severe hemophilia (PWH) A and B are aging, like their age-matched peers without hemophilia from the general population. Aging is associated not only with the comorbidities stemming from their inherited bleeding disorder (arthropathy, chronic viral infections such as hepatitis and AIDS) but also with the multiple chronic ailments associated with aging (cancer, cardiovascular disease, COPD).  Multimorbidity is inevitably associated with polypharmacy, i.e., the chronic daily intake of at least five drugs, and with the related risk of severe adverse events associated with the use of inappropriate drugs and drug-drug interactions. Information on the pattern of drug prescription and usage by PWH is relatively scanty, but on the whole, the available data indicate that the rate of polypharmacy, as well as the risk of drug-drug interaction, is relatively low in PWH and better than that in their age peers without hemophilia followed by general practitioners. It is believed that this advantage results from the collaborative coordination on drug prescribing exerted, through their integration with practitioners and organ specialists, by specialized hemophilia treatment centers in the frame of comprehensive care programs. However, the available cross-sectional data were mainly obtained in relatively young PWH, so that there is a need to obtain more accurate data from the ongoing prospective studies that are being carried out in more and more progressively aging PWH.

 

 Keywords: Hemophilia; Aging; Comorbidity; Drugs Interaction.
Geological and geochemical data from Mackenzie Corridor. Part IX: descriptions and associated measurements of cores from the Middle and Upper Devonian, Northwest Territories
Authors: Kabanov P , Borrero Gomez M -L
Published: August 2019

This report collects previously unpublished or updated descriptions of diamond-drill cores from exploration wells used as support materials for the Devonian Stratigraphic Framework study of GEM Mackenzie Project. Descriptions appear in original author's form
(text or striplog). Many descriptions are illustrated with core-face photos. On-core gamma spectrometry data of several cored intervals are published as well. Included are two continuously cored black-shale sections of Horn River Group in Kugaluk N-02 and Mirror Lake N-20 wells; cored section of the
Horn River Formation in Ebbutt D-50 well; cores of Ramparts carbonates in several wells; the cored section of the basal Hume Formation ('Headless Member') in Clare F-79 well and three cores historically used to characterize the Headless Formation in the vicinity of its type
area.
Controls on the ore fertility of arc magmas
Authors: Grondahl C , Tsay A , Zajacz Z
Published: August 2019

Continental arc magmas represent the parental igneous systems of porphyry Cu-Mo deposits. Studies exploring the fertility of these arcs are often based on global data sets or imperfect analogue settings such as oceanic basalts. We seek to refi ne our
understanding of continental arc magmatism in an economic context by sampling a suite of volcanoes in the Andean Southern Volcanic Zone (SVZ). Our sample suite extends from thick crust and the presence of world-class porphyry Cu deposits in the north to a barren south with thin crust. The most
primitive olivine-hosted silicate melt inclusions from these samples were analyzed by laser ablation inductively coupled plasma mass spectrometry for major and trace elements including S, Cu, Mo, and Ag. The quantitative analysis of S in silicate melt inclusions by Laser Ablation Inductively Coupled
Plasma Mass Spectrometry (LA-ICP-MS) required extensive analytical method development, which constitutes a significant part of this study. The application of non-modal batch melting models demonstrates that the partial melting of a sulfide-bearing primitive or depleted mantle source is capable of
generating the observed ore metal concentrations in the SVZ magmas and that there is no significant difference in the metal endowment of the barren and fertile segments of the arc. On the other hand, magmas in the fertile north exhibit significantly higher S concentrations.
Geothermal assessment of a conventional hydrocarbon reservoir in eastern Québec: preliminary field and petrophysical data
Authors: Larmagnat S , Lavoie D , Rajaobelison M
M , Raymond J
Published: August 2019

In eastern Québec, the Sayabec Formation is a lower Silurian carbonate unit well known for its natural macro porous intervals occurring both at the outcrop scale and in the subsurface, and interpreted as hydrothermal dolomite (HTD) units. The Sayabec
Formation represents a potential reservoir analog to the Albion-Scipio oil field (Ordovician, Michigan basin, USA) and has been targeted by a local oil and gas operator since 2010, which resulted in the drilling of about 6000 meters of stratigraphic wells in the Témiscouata area. This provided
an ideal case study to test how conventional methods for oil and gas exploration can be applied to assess geothermal properties of reservoir units. To better understand the conventional reservoir properties (e.g. porosity and permeability variability with respect to lithofacies), their spatial
heterogeneity and how these properties can be used to evaluate geothermal parameters; outcrops were revisited in the Témiscouata area to collect a consistent, although limited, new sample set of key sedimentary facies within the lower Silurian succession for this pilot project. A total of eight
distinctive lithologies were defined and analysed using both an infrared thermal conductivity scanner and probe permeametry, providing critical fine scale assessment of thermophysical properties of the lower Silurian carbonates and clastics. Those preliminary field data are compared with
pre-existing porosity and permeability laboratory measurements made on core samples from wells drilled in the same study area.
The Genus of a Random Bipartite Graph
Authors: Jing Yifan , Mohar Bojan
Published: August 2019

Archdeacon and Grable (1995) proved that the genus of the random graph$G\in {\mathcal{G}}_{n,p}$is almost surely close to$pn^{2}/12$if$p=p(n)\geqslant 3(\ln n)^{2}n^{-1/2}$. In this paper we prove an analogous result for random bipartite graphs in${\mathcal{G}}_{n_{1},n_{2},p}$. If$n_{1}\geqslant n_{2}\gg 1$, phase transitions occur for every positive integer$i$when$p=\unicode[STIX]{x1D6E9}((n_{1}n_{2})^{-i/(2i+1)})$. A different behaviour is exhibited when one of the bipartite parts has constant size,i.e.,$n_{1}\gg 1$and$n_{2}$is a constant. In that case, phase transitions occur when$p=\unicode[STIX]{x1D6E9}(n_{1}^{-1/2})$and when$p=\unicode[STIX]{x1D6E9}(n_{1}^{-1/3})$.
Об использовании бинарных операций при построении транзитивного множества блочных преобразований
Authors: Cherednik Igor Vladimirovich
Published: August 2019

Исследуется множество преобразований $\{\Sigma^F : F\in\mathcal B^*(\Omega)\}$, реализуемых сетью $\Sigma$ с одной бинарной операцией $F$, где $\mathcal B^*(\Omega)$ - множество всех бинарных операций на $\Omega$, обратимых по правой переменной. В терминах строения сети $\Sigma$ формулируется критерий биективности всех преобразований из семейства $\{\Sigma^F: F\in\mathcal B^*(\Omega)\}$. Определяются необходимые и достаточные условия транзитивности множества преобразований $\{\Sigma^F : F\in\mathcal B^*(\Omega)\}$, предлагается эффективный способ проверки этих условий. Приводится алгоритм построения таких сетей $\Sigma$, у которых множество преобразований $\{\Sigma^F : F\in\mathcal B^*(\Omega)\}$ является транзитивным.
Оценка температуры деконфайнмента в рамках подхода АдС/КХД
Authors: Katanaeva Alisa Dmitrievna , Afonin Sergei Sergeevich
Published: August 2019

Детально исследован ряд методов оценки температуры деконфайнмента в нединамических голографических моделях bottom-up. Показано, что, хотя существует много разных возможностей задать голографические параметры, некоторый набор рациональных теоретических и феноменологических ограничений на голографические модели приводит к реалистичным и достаточно стабильным предсказаниям диапазона температур в кроcсовер-области деконфайнмента при малых барионных плотностях. В частности, обсуждается, что наиболее удачным подходом является использование в качестве входных данных для улучшенной версии голографической модели с мягкой стенкой параметров скалярной глюбольной траектории, получаемых на решетке.
Волновые пакеты связанных состояний поля Дирака на материальной плоскости
Authors: Wegner Franz Joachim , Pis'mak Yury Mikhailivich
Published: August 2019

Недавно Письмак и Шухободская предложили модель дираковской частицы, взаимодействующей с материальной плоскостью. В зависимости от констант взаимодействия частица Дирака может быть в связанных состояниях, которые движутся параллельно плоскости и экспоненциально затухают в перпендикулярном к ней направлении. При этом волны с обеих сторон плоскости могут двигаться с разными скоростями. Хотя у состояний с резко выделенным импульсом, параллельным плоскости, нет перпендикулярных к ней токов, оказывается, что у рассматриваемых волновых пакетов есть слабая составляющая тока в этом направлении, удерживающая вместе волновые пакеты выше и ниже плоскости.
Кинетическая теория бозонного газа
Authors: Honkonen Juha , Komarova Marina Vladimirovna , Molotkov Yurii Georgievich , Nalimov Mikhail Yur'evich
Published: August 2019

Квантовая кинетическая теория бозонного газа со слабым взаимодействием построена с использованием усреднения произведений гaйзенберговских операторов поля в большом каноническом ансамбле. Теория возмущений для производящего функционала временны́х функций Грина при конечной температуре построена с помощью функционального представления теорем Вика для хронологических произведений. Отмечены проблемы построения представления в форме функционального интеграла. Обсуждаются обнаруженные необычные расходимости в теории возмущений. Предложена регуляризация этих расходимостей при помощи затухающих пропагаторов. С помощью линейного преобразования полей к переменным с хорошо определенными скейлинговыми размерностями построена инфракрасно эффективная теория поля. Показано, что структура регуляризованной модели воспроизводится ренормировкой. Предложена мультипликативно ренормируемая инфракрасно эффективная модель квантовой динамики бозонного газа.
Полярное разложение меры Винера: шварциановская теория в сравнении с конформной квантовой механикой
Authors: Belokurov Vladimir Viktorovich , Shavgulidze Evgeni Tengizovich
Published: August 2019

Найден явный вид полярного разложения меры Винера и получено уравнение, связывающее функциональные интегралы в конформной квантовой механике с функциональными интегралами в шварциановской теории. С помощью этой связи вычислены некоторые нетривиальные функциональные интегралы в шварциановской теории, а также найдено фундаментальное решение уравнения Шредингера в мнимом времени в модели конформной квантовой механики.
Пассивный перенос в перколяционном процессе: двухпетлевое приближение
Authors: Birnsteinova Sarlota , Gnatich Michal , Lučivjansky Tomas , Mizisin Lukas , Skultety Viktor
Published: August 2019

Исследуется поучительная модель процесса направленной перколяции вблизи точки фазового перехода второго порядка между поглощающим и активным состояниями. Модель сначала задается уравнением Ланжевена, а затем переписывается в теоретико-полевой формулировке. Далее с использованием техники фейнмановских диаграмм и ренормгруппового подхода к теории возмущений проанализирован получающийся функционал отклика. Предполагается, что процесс перколяции происходит во внешнем поле скоростей, которое оказывает дополнительное влияние на свойства протекания. Для генерации флуктуаций скорости используется ансамбль Крейчнана быстрых изменений. В двухпетлевом приближении получена структура множества неподвижных точек.
Сильноинтенсивные флуктуации между множественностью и полным поперечным импульсом в $pp$-взаимодействиях в подходе мультипомеронного обмена
Authors: Andronov Evgenii Vladimirovich , Kovalenko Vladimir Nikolaevich
Published: August 2019

Проведены вычисления подавляющих тривиальные объемные флуктуации сильноинтенсивных переменных $\Sigma$ и $\Delta$, построенных для множественности заряженных частиц $n$ и суммарного поперечного импульса $P_\mathrm{t}$ в модифицированном подходе мультипомеронного обмена для протон-протонных взаимодействий в диапазоне энергий столкновения, достигаемых на ускорителях SPS и LHC. В данном подходе эффективно учитывается взаимодействие между цветовыми кварк-глюонными струнами, которые образуются из разрезанных померонов, причем роль этих взаимодействий возрастает с энергией столкновений. Основным результатом вычислений для энергий, достигаемых на SPS, являются неравенства $\Sigma(P_\mathrm{t},n)>1$ и $\Delta(P_\mathrm{t},n)<1$, которые согласуются с экспериментальными данными. Показано, что с увеличением энергии $\Sigma(P_\mathrm{t},n)$ ведет себя немонотонно, а $\Delta(P_\mathrm{t},n)$ возрастает.
$(2+1)$-мерная гравитация, взаимодействующая с пылевой оболочкой. Квантование в терминах глобальных переменных фазового пространства
Authors: Andrianov Aleksandr Andreevich , Starodubtsev Artem Nikolaevich , Elmahalawy Yasser Reda
Published: August 2019

Проводится канонический анализ модели, в которой гравитация взаимодействует со сферически-симметричной пылевой оболочкой в $2+1$ измерениях пространства-времени. Результатом является редуцированное действие, зависящее от конечного числа степеней свободы. Основной акцент сделан на нахождении канонических переменных, которые обеспечили бы глобальную параметризацию всего фазового пространства модели. Оказывается, что различные области импульсного пространства, соответствующие различным ветвям решения уравнений Эйнштейна, образуют единое многообразие с геометрией AdS$_2$. Глобальная параметризация этого многообразия обеспечивается углами Эйлера. Квантование в этих переменных ведет к некоммутативности, а также к дискретности в координатном пространстве, что позволяет устранить центральную сингулярность. Также найдено преобразование между полученным здесь импульсным пространством AdS$_2$ и импульсным пространством в переменных Кухаржа, что может оказаться полезным при обобщении полученных результатов на случай $3+1$ измерений.
Ренормгрупповой анализ моделей переноса векторной примеси и поля трейсера турбулентным сжимаемым потоком
Authors: Antonov Nikolai Viktorovich , Gulitskii Nikolai Mikhailovich , Kostenko Mariya Mikhailovna , Lučivjansky Tomas
Published: August 2019

С помощью квантово-полевой ренормализационной группы рассматриваются модели переноса векторного поля и поля трейсера сжимаемым турбулентным потоком. Обе примеси считаются пассивными, т. е. не имеющими обратного влияния на динамику жидкости. Поле скорости задается с помощью стохастического уравнения Навье-Стокса. Модель рассматривается вблизи специальной размерности пространства $d=4$. Анализ модели вблизи данной размерности позволяет построить двойное разложение по параметрам $y$ (связанному с коррелятором случайной силы поля скорости) и $\varepsilon=4-d$. Показано, что в рамках однопетлевого приближения обе модели имеют схожее скейлинговое поведение, т. е. поведение корреляционных и структурных функций в инерционном интервале. Все критические размерности, в частности тензорных составных операторов, посчитаны в первом порядке двойного разложения по $y$ и $\varepsilon$.
First identification and quantification of detached-tip vortices behind a wind energy converter using fixed-wing unmanned aircraft system
Authors: Mauz Moritz , Rautenberg Alexander , Platis Andreas , Cormier Marion , Bange Jens
Published: August 2019

Abstract. In the present study, blade-tip vortices have been experimentally identified in the wake of a commercial wind turbine using the Multi-purpose Airborne Sensor Carrier Mark 3 (MASC Mk 3) unmanned aircraft system (UAS) of the University of Tübingen.
By evaluation of the wind components, detached blade-tip vortices were identified in the time series. From these measurements, the circulation and core radius of a pair of detached blade-tip vortices is calculated using the Burnham–Hallock (BH) wake vortex model. The presented data were captured under a dominating marine stratification about 2km from the North Sea coastline with northern wind direction. The measured vortices are also compared to the analytical solution of the BH model for two vortices spinning in opposite directions. The model has its origin in aviation, where it describes two aircraft wake vortices spinning in opposite directions. An evaluation method is presented to measure detached-tip vortices with a fixed-wing UAS. The BH model will be used to describe wake vortex properties behind a wind energy converter (WEC). The circulation and core radius of detached blade-tip vortices will be calculated. Also a proposition of the model for WEC wake evaluations will be made to describe two independent co-rotating vortices.
Quantifying blade-tip vortices helps to understand the process of vortices detaching from a rotor blade of a wind turbine, their development in the wake until finally dissipating in the far wake and contributing to overall atmospheric turbulence. This is especially interesting for set-ups of numerical simulations when setting the spatial resolution of the simulation grid.
STEM Career Preferences of the Anatolian High School Students from Different Socioeconomic Levels
Authors: Kızılay Esra , Yamak Havva , Kavak Nusret
Published: August 2019

The purpose of this study is to reveal the science, technology, engineering and mathematics (STEM) career preferences in university of the students at different socioeconomic levels studying in Anatolian high schools and the relation between their socioeconomic levels and preferences. The research is performed with 886 students studying in Anatolian high schools in Kayseri province in the second term of the 2016-2017 academic year. The data is gathered via a form with demographic information and university career preferences of the students. The socioeconomic levels of the students are determined and their university career preferences are coded as STEM career field or non-STEM career field. In the analysis of the data, the SPSS 22 program is utilized. In the analysis of the data, frequency, percentage, and chi-square analysis are used. In the research, a significant relation is found between the socioeconomic levels of the students and whether their university career preferences are within the STEM field or not.
Applying a Commercialization-Readiness Framework to Optimize Value for Achieving
Sustainability of an Electronic Health Data Research Network and Its Data Capabilities:
The SAFTINet Experience
Authors: Morrato Elaine H. , Hamer Mika K. , Sills Marion , Kwan Bethany , Schilling Lisa M.
Published: August 2019

Context: Sustaining electronic health data networks and maximizing return on
federal investment in their development is essential for achieving national data insight
goals for transforming health care. However, crossing the business model chasm from
grant funding to self-sustaining viability is challenging.Case description: This paper
presents lessons learned in seeking the sustainability of the Scalable Architecture for
Federated Translational Inquiries Network (SAFTINet), and electronic health data network
involving over 50 primary care practices in three states. SAFTINet was developed with
funding from the Agency for Healthcare Research and Quality to create a multi-state
network for comparative effectiveness research (CER) involving safety-net
patients.Methods: Three analyses were performed: (1) a product gap analysis of
alternative data sources; (2) a Strengths-Weaknesses-Opportunities-Threat (SWOT)
analysis of SAFTINet in the context of competing alternatives; and (3) a customer
discovery process involving approximately 150 SAFTINet stakeholders to identify
SAFTINet’s sustaining value proposition for health services researchers, clinical data
partners, and policy makers.Findings: The results of this business model analysis
informed SAFTINet’s sustainability strategy. The fundamental high-level product needs
were similar between the three primary customer segments: credible data, efficient and
easy to use, and relevance to their daily work or ‘jobs to be done’. However, how these
benefits needed to be minimally demonstrated varied by customer such that different
supporting evidence was required.Major Themes: The SAFTINet experience illustrates that
commercialization-readiness and business model methods can be used to identify
multi-sided value propositions for sustaining electronic health data networks and their
data capabilities as drivers of health care transformation.
The Agreement Theta Generalization
Authors: Polinsky Maria , Preminger Omer
Published: August 2019

In this paper, we propose a new generalization concerning the structural relationship between a head that agrees with a DP in φ-features and the predicate that assigns the (first) thematic role to that DP: the Agreement Theta Generalization (ATG). According to the ATG, configurations where the thematic-role assigner is located in a higher clause than the agreeing head are categorically excluded. We present empirical evidence for the ATG, discuss its analytical import, and show that this generalization bears directly on the proper modeling of syntactic agreement, as well as the prospects for reducing other syntactic (and syntacto-semantic) dependencies to the same underlying mechanism.
Potential prognostic value of PD-L1 and FOXP3 as predictors of relapse in breast cancer
Authors: Nagib Reham , Refat Sherine , Eladl Ahmed E. , Emarah Ziad , Elnaghi Khaled
Published: August 2019

Background: Expression of PD-L1 detected by immunohistochemistry can represent a new hope for cancer management. The role of PD L1 in breast cancer is still unclear. Similarly, is the role of tumor-infiltrating FOXP3 +ve regulatory T (Treg) cells where literature data are conflicting. Our study aimed to evaluate the immunohistochemical expression of PD L1 and FOXP3 in breast cancer, correlate them with clinicopathological parameters as well as evaluating their relation.Methods: This is a retrospective study carried out on 136 breast cancer specimens. Only cases with proved pathological diagnosis of infiltrating duct carcinoma of no special type (NST) were included. Tissue microarray blocks were constructed and immunostained with the polyclonal antibody for PDL1 and monoclonal antibody for FOXP3.Results: Statistically significant correlation was found between high FOXP3 and nearly all adverse prognostic factors including; grade III tumors (p = .003), basal-like subtype(p = .001), high Ki67(p = .001), negative ER status(p = .001), negative PR(p = .028), HER2 expression(p = .04), advanced stage (p = .001), and LN metastases(p = .001). For PDL1, only statistically significant correlation with high Ki67 (p = .018) and advanced stage(p = .03) was found. A statistically significant positive correlation was found between PD L1 and FOXP3(p= .001). No statistically significant correlation was found between both PDL1 and FOXP3 in relation to disease-free survival (DFS) (p = .054). PDL1, age (≥ 50 years), nodal metastases were significant predictors of relapse in breast cancer.Conclusion: The current study supports PDL1 as a predictor of relapse in breast cancer. Additionally, it highlights the synergistic role between PDL1 and FOXP3 in breast cancer microenvironment. Each can be considered as a poor prognostic marker in breast cancer. This raises a concern about the benefit of breast cancer patients from blocking of PDL1 pathway.
Assessment of minimum vertical reinforcement limits for RC walls
Authors: Henry R. S.
Published: August 2019

During the 2010/2011 Canterbury earthquakes, several reinforced concrete (RC) walls in multi-storey buildings formed a single crack in the plastic hinge region as opposed to distributed cracking. In several cases the crack width that was required to accommodate the inelastic displacement of the building resulted in fracture of the vertical reinforcing steel. This type of failure is characteristic of RC members with low reinforcement contents, where the area of reinforcing steel is insufficient to develop the tension force required to form secondary cracks in the surrounding concrete. The minimum vertical reinforcement in RC walls was increased in NZS 3101:2006 with the equation for the minimum vertical reinforcement in beams also adopted for walls, despite differences in reinforcement arrangement and loading. A series of moment-curvature analyses were conducted for an example RC wall based on the Gallery Apartments building in Christchurch. The analysis results indicated that even when the NZS 3101:2006 minimum vertical reinforcement limit was satisfied for a known concrete strength, the wall was still susceptible to sudden failure unless a significant axial load was applied. Additionally, current equations for minimum reinforcement based on a sectional analysis approach do not adequately address the issues related to crack control and distribution of inelastic deformations in ductile walls.
Which Perennial Crop Farm Approach Generates More Profitability? A Case Study in Dak Lak province, Vietnam
Authors: Thuy Phan Thi , Ho Thi Minh Hop , Burny Philippe , Niem Le Duc , Lebailly Philippe
Published: August 2019

Dak Lak Province, Vietnam has been identified as the optimal growing area region of cash crops. However, in recent years, perennial crops have faced some challenges need to have a new approach to maintain production sustainability. This study primarily provides a comparative analysis of the economic performance of crop cultivation by two approaches, mono-crop approaches including mono-coffee farms (MCFs) and mono-pepper farms (MPFs); intercropped approaches comprising intercropped coffee farms (ICFs) and intercropped pepper farms (IPFs). Additionally, this paper identifies the main factors affecting the farmer’s adoption decision on different intercropped farm types. Based on an investigation of 120 selected farms, focus group discussions (FGDs) and participant assessments, from January to April 2019, the information about farming operations, costs and profits also were collected. The findings indicated that intercropped farms (include ICFs and IPFs) had a higher reduction of variable costs than mono-crop farms (MCFs and MPFs). Likewise, between two intercropped farm types, ICFs that wasted fewer input costs seem to be more appropriate for the poor and small saving households than that of IPFs. Moreover, ICFs and IPFs generate more profitability, increase by 62 % and 25.7 % as compared with MCFs and MPFs, respectively. Going forward, the study revealed factors influencing farmers’ decision-making on applying different approaches for intercropped farms. These comprise farm profiles (pest and disease status; the age of the tree), farmers’ characteristics (training) and economic factors (profits and other income). The findings devote information to intercropped farms in terms of enhancing economic benefits should be promoted for the coming years. Looking beyond, this empirical evidence is likely a useful contribution to farming management. What’s more, the factors highlighted here demonstrate the need for continued improvement in such farming strategies.