bluuebunny/crossref_metadata_2025 huggingface dataset:
Mitral anülüs kalsifikasyonunun elektrokardiyogram parametreleri üzerinde etkileri
Authors: KUYUMCU Mevlüt
Published: December 2018

Amaç: Mitral anüler kalsifikasyon (MAK) mortalite
indikatörü olan azalmış kalp hızı değişkenliği, bozulmuş P dalgası dispersiyonu
ve atriyal elektromekanik gecikme ile ilişkili olduğu saptanmıştır. MAK’ın
potansiyel aritmojenik etkileri olabileceğini göz önüne alarak çalışmamızda
MAK’ın kalbin elektrofizyolojisi üzerine etkilerini klasik EKG parametrelerine
ek olarak f(QRS‐T) açısı ve Tp-e/QT gibi yeni aritmojenik idikatörleri
kullanarak araştırmayı amaçladık.

Hastalar ve Yöntemler: Toplam 200 ardışık hasta [n=100
MAK (+) ve n=100 MAK (-)] çalışmaya dahil edildi. Toplanılan tüm veriler ve elektrokardiyogram parametreleri
gruplar arasında karşılaştırıldı.

Bulgular: P Dalgası MAK (+) grubunda, kontrol
grubuna göre anlamlı şekilde uzun izlenmiştir (p<0.001). Düzeltilmiş QT intervali MAK (+) grubunda,
kontrol grubuna göre anlamlı olarak uzun izlenmiştir (p<0.001). Tp-e intervali MAK (+) grubunda,
kontrol grubuna göre anlamlı olarak uzun izlenmiştir (p<0.001). Tp-e/ QT intervali ve Tp-e/ düzeltilmiş QT intervali
oranı MAK (+) grubunda, kontrol grubuna göre anlamlı olarak uzun izlenmiştir (p<0.001). Frontal QRS-T açısı
MAK (+) grubunda anlamlı olarak fazla izlenmiştir (p<0.001).

Sonuç: Çalışmamızda MAK’ın EKG üzerindeki
etkileri değerlendirilmiştir ve literatürde ilk kez MAK’ın kalbin
repolarizasyon parametreleri üzerinde negatif etkileri olduğu saptanmıştır.
Bireysel kalite göstergesi olan motivasyonu etkileyen faktörlerin orman işletmelerinde incelenmesi: Gümüşhane ili örneği
Authors: ARDIÇ Muhammed
Published: December 2018

Günümüz
işletmelerinde üretim ve maliyetleri etkileyen en temel etkenlerin başında
insan faktörü gelmektedir. İnsan karmaşık yapısı dolayısı ile üretim sürecinin
en güç kontrol edilebilen faktörüdür Bu sebeple motivasyon, üretimde çalışan
kişileri belirli bir amaca yönlendiren ve verimliliği artırarak dolaylı olarak
maliyetleri düşüren bir kavramdır. Bu çalışmada, Gümüşhane ilinde faaliyette
bulunan orman işletmeleri örneği yardımıyla işletme çalışanlarının motivasyon
durumları; motivasyon eksiklikleri ve tatmin oldukları konular açısından
belirlenmeye çalışılmıştır. Ayrıca çalışanların motivasyonları ile yaş,
cinsiyet, gelir, eğitim, hizmet süresi ve medeni durum gibi bazı kişisel
özellikleri arasındaki ilişkiler de incelenmiştir. Sonuç olarak, Gümüşhane
ilinde faaliyette bulunan orman işletmeleri çalışanlarının motivasyonunu; yönetim-çalışan
ilişkisi, sağlık problemleri, ücret, işin niteliği ve çalışma koşuları, çalışma
arkadaşlarıyla olan ilişki, terfi/yükselme gibi faktörlerin önemli oranda
etkilediği ortaya çıkmıştır. Ayrıca çalışanların motivasyonunun yaş grupları,
eğitim düzeyi, gelir, çocuk sayısı, işletmelerdeki toplam çalışma süresi ve
mevcut işletmedeki çalışma süresi değişkenlerine göre farklılaşırken, cinsiyet
ve medeni durum değişkenlerine göre farklılaşmadığı belirlenmiştir.
Test Protocol December 5th 2018 v1
Authors: Testing Anita
Published: December 2018

This is a test.
Possibilities of modern neuroimaging techniques in the diagnostics and neuromonitoring of the recovery process in patients after ischemic stroke
Authors: Ekusheva E. V. , Kiparisova E. S. , Kurzanceva O. O. , Smirnova O. A.
Published: December 2018

Ischemic stroke is still leading in terms of primary disability caused by residual neurologic de-fect in the majority of patients. Persistent motor disorders are observed even after timely and ade-quately carried out rehabilitation measures. The article discusses the possibilities of modern instru-mental technologies for diagnostics and further monitoring of the process of restoration of post-stroke deficit, which is based on the phenomenon of neuroplasticity.
Methods for prevention of intraoperative rupture during surgical interventions of intracranial aneurysm clipping
Authors: Kim S. V. , Shin A. R. , Vinokurov A. G. , Klypa T. V. , Baklaushev V. P. , Troitsky A. V.
Published: December 2018

Intraoperative aneurysmal rupture (IAR) is one of the most dramatic complications of intracranial intervention. Its frequency, depending on the aneurysm’s localization and anatomical features, may reach 50%. IAR leads to the increase of unfavorable outcomes by 1.5–3 times. There exists a variety of techniques aimed to reduce the frequency of this complication, however, all of them have essential limitations.

The review presents analyses of the basic risk factors for IAR and techniques of its prevention, as well as modern approaches directed at the alleviation of this complication’s consequences.
Effect of Combination of Solarization and Soil Fumigation on Root-knot Nematodes (Meloidogyne spp.) (Nematoda: Meloidogynidae) in Greenhouses
Authors: ÖZARSLANDAN Adem , BOZBUGA Refik , DİNÇER Dilek
Published: December 2018

Root knot nematodes are
economically important crop pests that is difficult to control. Soil fumigation
and solarization are significant methods to control root knot nematodes. The
application of soil fumigation and solarization on nematodes is not fully understood.
Therefore, this study was carried out to determine the effect of the
combination of the solarization with reduced dose of metam-sodium to control
root knot nematodes in pepper. Experiments were conducted in greenhouses in
Adanalıoğlu and Kazanlı region of Mersin province in 2014-2015. Following the
planting beds were prepared in the experiments, the solarization with reduced
metam-sodium fumigant was applied at 750 l/ha. The plots were saturated via
drip irrigation, and waited for two days before metam-sodium was applied with
100 ton/ha water. The solarization application in July 2014 combined with
reduced metam-sodium treatment were effectively protected pepper against
root-knot nematodes until July 2015 where gall formation ranged between 0-1.4.
Solarization combination with reduced metam-sodium application resulted with
gall formation below 2 while in non-treated parcels were ranged from 6.4 to
7.1. Solarization with reduced metam-sodium application resulted 98,8% to
234,5% yield increase in pepper. Results indicate that combination of
solarization with reduced metam-sodium application reduced the root-knot
nematodes. It is thought that when the manufacturers apply the solarization
with combination of metam-sodium correctly, they will not have nematode
problems and the possibility of encountering lower ineffectiveness of the chemicals.
Consideraciones acerca de la objetividad del método en ciencias sociales a partir del pensamiento de Max Weber y su importancia especifica en el campo del trabajo social
Authors: Llana Luciana
Published: December 2018

Resumen:En éste artículo tratamos de pensar de qué manera, a través del pensamiento de Marx Weber, el investigador social puede acercarse a su objeto de estudio teniendo en cuenta que la objetividad, con que se acerca a los fenómenos sociales, esta mediada por su propia subjetividad, lo que a nuestro entender no es un inconveniente, sino esencial para una ética científica. A su vez pensamos que estos planteos no son incompatibles con pensar la realidad en su devenir dialectico, tal como lo plantea el marxismo.
La incidencia de la tesis de la neutralidad valorativa en la enseñanza de las ciencias económicas Ética, economía y educación: por una enseñanza pluralista de las ciencias económicas
Authors: Beraldi Gastón
Published: December 2018

Tomando como punto de partida los recientes cuestionamientos que, desde distintos movimientos de grupos de economistas y estudiantes de economía, vienen realizándose a la ortodoxia de la enseñanza de las ciencias económicas, en este estudio pretendemos, en primer lugar, evaluar la incidencia de la tesis de la neutralidad valorativa de las ciencias en la enseñanza de la economía, sosteniendo que la tan mentada neutralidad valorativa no es más que un mito, puesto que es ella misma un valor, y en segundo lugar, frente a esto, señalar la necesidad del disenso y de una enseñanza más pluralista que posibilite la construcción de un verdadero estado democrático.
Michel Foucault Tecnologías de gobierno y prácticas de libertad Últimos desplazamientos Renovadas problematizaciones
Authors: Sepúlveda Julio César
Published: December 2018

Una manera no poco frecuente de abordar la obra de Michel Foucault, coincide en apreciarla a través de períodos: el primero de ellos, vinculado a una indagación por el saber y denominado arqueológico, el segundo, conocido como genealógico y cuya preocupación central es la cuestión del poder; y un tercer y último período, en el que nos ofrece una particular versión de la ética. Abundan así, los estudios sobre el pensador francés, que consideran su obra como una sucesión de bloques o bien temáticos o bien metodológicos, una especie de sucesión no carente de rupturas e incluso contradicciones
Los posgrados de humanidades y ciencias sociales en la mira
Authors: Montañez Silvia , Landini María Luisa , Grillo Pardo Susana
Published: December 2018

Los posgrados que están desarrollándose en las universidades estatales se plantean constantemente distintos tipos de evaluaciones. Algunas externas, como las emanadas de CONEAU, que los habilita para su desenvolvimiento, y otras internas, como los análisis para mejorar sus trayectorias. En el marco del 7º Encuentro de Investigadores de Ciencias Sociales de la Región Centro Oeste, llevado a cabo en el Instituto de Investigaciones Socioeconómicas de la Facultad de Ciencias Sociales de la Universidad Nacional de San Juan, se conformó, propuesto por la Maestría en Metodología de la Investigación en Ciencias Sociales, el Panel “Los posgrados en ciencias sociales y humanas: reflexiones sobre sus prácticas”. En este documento se presentan los ejes que resumen las inquietudes presentadas en dicha actividad: propuestas institucionales para apoyar los posgrados, las actividades de gestión, algunos principios de evaluación de los mismos y las preocupaciones en curso.
Las políticas educativas en la Historia de la Educación Un aporte para el estudio de las políticas educativas, en el Centenario de la Revolución Argentina
Authors: Laura Guic
Published: December 2018

Licenciada en Gestión Educativa (UNLA). Especialista en Investigación Educativa (UNLA). Doctorandadel Programa Interuniversitario de Educación. Investigadora del Instituto de Cultura de la UniversidadNacional de Lanús.
Self-Supporting Hybrid Supercapacitor Electrodes Based on Carbon Nanotube and Activated Carbons
Authors: Temirgaliyeva T.S. , Kuzuhara S. , Noda S. , Nazhipkyzy M. , Kerimkulova A.R. , Lesbayev B.T. , Prikhodko N.G. , Mansurov Z.A.
Published: December 2018

Self-supporting AC (activated carbon)-FWCNT (few-wall carbon nanotubes) hybrid electrodes were fabricated by mixing of ACs with high specific surface area (SSA) and sub-millimeter-long FWCNTs. In order to fabricate the hybrid electrodes, AC and FWCNT were mixed in a weight ratio of 9:1, dispersed by bath-sonication and vacuum-filtrated on a membrane filter. The addition of FWCNTs gives conductivity and mechanical strength, and replace metallic current collectors in thick (0.1 mm) electrodes. For making an electrode, three different ACs that derived from walnut shell (WS), that from apricot stones (AS), and that commercially used for capacitors (YP-80F, Kuraray Chemical Co., Osaka Japan), were used with FWCNT in weight ratio of AC:FWCNT = 9:1. An electrode based only on FWCNT was also prepared as a reference for comparison. Electrochemical properties of the obtained electrodes were investigated by the cyclic voltammetry method (CV). Electrochemical characteristics were measured using the three-electrode cell contained of YP80F-FWCNT, AS-FWCNT, WS-FWCNT as a working electrode, a YP-80F-FWCNT counter electrode and a Ag/AgCl reference electrode with an electrolyte of 1 M Na2SO4 aqueous solution. Also, the morphological properties of obtained electrodes were studied using scanning electron microscope (SEM), the SSA was investigated by the Brunauer-Emmett-Teller analysis. SSA, conductivity, and resistivity of AS-FWCNT and WS-FWCNT electrodes were summarized. Both the AS-FWCNT and WS-FWCNT hybrid electrodes showed specific capacitances of about 140 F/g at 1 mV/s and about 100 F/g at 100 mV/s, which are similar or even better than the AC-CNT hybrid electrode made of commercialized AC (YP-80F).
Separation Efficiency of Water/Oil Mixtures by Hydrophilic and Oleophobic Membranes Based on Stainless Steel Meshes with Openings of Various Sizes
Authors: Sultanov F.R. , Daulbayev Ch. , Bakbolat B. , Mansurov Z.A.
Published: December 2018

This article is focused on development of hydrophilic and oleophobic composition which serves as a coating for substrate presented by stainless steel meshes with different sizes of their openings. Membranes obtained by dip-coating method are hydrophilic and oleophobic and this may be applied for efficient separation of organic liquids and water by simple and inexpensive gravitational separation. Investigations presented in the article show that the size of openings of meshes influence on the formation of hydrophilicity and oleophobicity of membrane, as well as the nature of used polymers, which serve as a coating, since membranes based on 400 mesh coated with Poly(diallyldimethylammonium chloride) (PDDA)/ pentadecafluorooctanoic acid (PFOA)/SiO2 demonstrate different wettability in regard to organic liquids of different densities. In particular, membrane based on mesh 400 coated with PDDA/PFOA/SiO2 exhibits strong oleophobicity to less dense non-polar organic solvents – kerosene, which does not penetrate the membrane, while more dense liquids, such as vacuum pump oil, are able to penetrate it, but the rate of penetration is rather slow, 10 ml per 21 min. Obtaining of membranes with uniform coating by hydrophilic-oleophobic compositions without clogging of their openings and creation of openings of required sizes for a particular case is also a subject of study of this article.
Use of Onion-Like Carbon to Reinforce Carbon Composites
Authors: Galiguzov A. , Malakho A. , Minchuk S. , Oktiabrskaia L. , Lepin V.
Published: December 2018

Onion-like carbon reinforced carbon-carbon composite was fabricated, and the influence of onion-like carbon (OLC) on the microstructure and mechanical and friction properties was investigated by porosity analysis, scanning electron microscopy, three-point bending test, nanoindentation test and ring-on-ring friction test. The results show that the sample containing OLC has a higher flexural strength (by 7.3%) and compressive strength (by 29.3%), hardness (by 2.1 times) and apparent density (by 1.1%) and smaller open porosity (7.9% vs 9.8%) and mesopore volume, which is confirmed by porosity analysis and is attributed to improved fiber/ matrix interface performance. The presence of OLC results in higher hardness and elastic modulus of carbon matrix under nanoindentation testing, which leads to modification of friction mechanism and a decrease in the wear rate under friction (by 3.3 times). Besides, OLC particles form self-lubricating film and show a graphitic carbon solid lubricant properties.
Nanosized Catalysts in the Process of Hydrogenating Acetylene
Authors: Tanirbergenova S.K. , Zhylybayeva N.K. , Tairabekova S.Zh. , Tugelbayeva D.A. , Naurzbayeva G.M. , Moldazhanova G.M. , Mansurov B.A.
Published: December 2018

Hydrogenating process of the acetylene to ethylene using automated flow catalytic installation at nanoscaled catalysts Ni, Co and carriers at a pressure of 5 atm was studied. The actions of carriers and nanosized catalysts during hydrogenation reaction of acetylene to ethylene at low temperatures in the range from 50–120 °С were analyzed. With ratio of С2Н2:Н2 being equal to (1:2), at 80 °С the aluminum oxide carrier exhibits an activity, conversion of acetylene makes up 70%, when using zeolite 3A it is 63%. When the temperature rises to 120 °С, the aluminum activity is decreasing and conversion is 53%. However, zeolite exhibits its activity at high temperatures, at a temperature of 120 °С conversion of acetylene reaches to 73.5%. It is shown that with increasing of hydrogen ratio, the ethylene yield increases from 5 to 10.7% using catalyst 5% Ni/3A. In addition, in reaction of acetylene hydrogenation there are not formed waste products. For this process, the optimum reaction temperature is 80 °С, feedstock ratio (1:3) is positive, where the ethylene yield increased up to 16.7% and at catalyst to 5% Co/3A.
Perkembangan Kubah Batu, Masjid Damaskus, Perluasan Masjid Al-Haram dan Masjid Nabawi pada Masa Khalifah Abdul Malik Bin Marwan dan Walid Bin Abdul Malik
Authors: Saputri Itsnawati Nurrohmah
Published: December 2018

This research describes the building that was built and renovated during the regimes of Khalifah Abdul Malik bin Marwan and Walid bin Abdul Malik. The method used in this study is the historical method, which uses the approach of cultural anthropology, and the theory of cultural acculturation. The technique of data collection is by literature study. The result of this research is in the era of Abdul Malik bin Marwan, built Qubat as-Shkhrah/Dome of the Rock in Jerusalem, until today become one of the greatest Islamic monuments. In the Dome of the Rock Mosque, the masonry building style mixed from Byzantine and Persian culture. In the era of Walid bin Abdul Malik built the famous grand mosque of Damascus Mosque. The construction of the mosque was also affected by the Byzantine culture, because the earlier Damascus mosque was a converted church to become a mosque. The effect on the original building form has a simple pattern, having gained influence from the outside culture adds to the shape of the building and does not change the initial shape of the initial pattern. During the reign of Khalifah Abdul Malik and al-Walid I did an expansion in Masjid al-Haram and Masjid Nabawi.
FAMILY QUALITY OF LIFE IN PRACTICE: A PRACTICAL APPLICATION OF THE FQOL-2006 SURVEY
Authors: Butler Kierstyn
Published: December 2018

As families are increasingly recognized as the primary caregivers for their family members with disabilities, family quality of life (FQOL) research has focused on the impact of disability within the family. This field of research seeks to gain an understanding of the complex challenges and successes families have, with the goal of assisting families in expanding their FQOL. To accomplish this task, the FQOL survey (FQOL-2006) was created. Developed in 2000 and later revised, the FQOL-2006 survey has been used in over 20 countries to explore the perceptions of families, parents, and main caregivers of individuals with intellectual and developmental disabilities. While there has been considerable research using the FQOL-2006 survey, there is limited research that focuses on integrating the survey into practice. This article discusses a possible application of the survey in practical contexts by reflecting on some of the qualitative data collected from my recent FQOL master’s thesis study. Specifically, the article highlights the mutual benefits that service providers and families could receive by integrating the FQOL-2006 survey into service models, as it could allow professionals to establish a framework for assessing each client-family’s overall quality of life, including their greatest supports, strengths, challenges, and needs. This application provides a new research opportunity for the FQOL field for both researchers and professionals.
HEALTH-RELATED FAMILY QUALITY OF LIFE WHEN A CHILD OR YOUNG PERSON HAS A DISABILITY
Authors: Kyrkou Margaret R.
Published: December 2018

Parents of a child or young person with disability face not only the same challenges as parents of typically developing children and young people, but also the extra challenges of supporting the child or young person with disability in such a way as to maximise both their own quality of life (QOL) and family quality of life (FQOL) for all family members. Health-related quality of life (HRQOL) encompasses not only physical health but also mental and emotional health, equally important for FQOL. This article builds on information from previous publications, and illustrates relevant issues and the innovative methods parents, caregivers, and professionals have devised to enhance the HRQOL for children and young people with disability, and to improve FQOL. The author draws upon her personal lived experiences of having two daughters, the eldest an adult with disability, as well as being the medical consultant and manager of a newly created health unit tasked with supporting students with disability, who often have high health needs, in educational settings. The health conditions selected are those that have a major impact, not only on the young person with disability but also on family members. Vignettes, all deidentified true stories, will be included to illustrate the multiple issues faced by children and young people with disability, their families and extended families, and treating clinicians. These stories will hopefully resonate with families in particular.
“SPECIAL” FAMILIES AND THEIR “NORMAL” DAILY LIVES: FAMILY QUALITY OF LIFE AND THE SOCIAL ENVIRONMENT
Authors: Boelsma Femke , Schippers Alice , Dane Menco , Abma Tineke A.
Published: December 2018

This article focuses on the social and societal factors that influence family quality of life (FQOL). In this qualitative study from the Netherlands, a multiple case study design was used, in which members of families having a child or children with intellectual and developmental disabilities talked about their experiences during interviews. The data were analysed through a rigorous inductive thematic analysis. Our findings relate to the families’ experiences with their social environment and especially with the support they received. We argue that processes of acceptance and understanding play a role in FQOL. Also, we illustrate how the family members experience their interaction with the community, and how moral norms and values could influence the lives of the families. The families reflected on notions of normality and being different, and sometimes struggled with the implicit norms and values of society, which can impede acceptance and understanding by others. In turn, these norms and values influence the level of support from other people and the possibilities for social interaction with the community.
PAINTING PICTURES: TOWARDS CONNECTING THROUGH IMAGERY IN DIALOGUES WITH YOUNG PEOPLE WITH INTELLECTUAL DISABILITY
Authors: Peels Hanna , Sergeant Sofie
Published: December 2018

The authors discuss pivotal themes in the use of imagery (visual and verbal) as a method to engage in dialogue with young people with intellectual disability (ID). In their discussion they reflect on co-occurring changes in Dutch society, the nature of caregiving, and the increasing appeals for empowerment for and by people with ID. A critical dialogue is used to analyse experiences with imagery from their previous research, and the possibilities imagery harbours to improve dialogues on quality of life with young people with ID. Through analysis of the critical dialogue, five themes were identified: leitmotiv, ambiguity, choice, revelation, and distance. To conclude, the authors discuss why family members and professional support workers should consider using imagery as a productive methodology.
The Relationship between Work-Family Conflict, Job Stress, and Accidental Potential: A case study of Tehran-Shahrood fiber optic line construction project
Authors: Pak Panah Kianoosh , Khoshmanesh Zadeh Behnoush , Razavian Fatemeh
Published: December 2018

Introduction: Today, work-family conflict and occupational stress are considered as a common and costly problem in work environments. Almost all people are faced with such challenges. Work-family conflict is a sub-set of psychological factors. The main purpose of this research was to measure the correlation among work-family conflict, occupational stress, and incident talent. Moreover, we classified the employees in each of these three variables.Methods: In order to collect data in this applied research, we used questionnaire. The statistical population included all the employees of a fiber-optic line construction project. A total of 250 samples were selected randomly. Data were analyzed using Spearman correlation test, frequency distribution, mean, and standard deviation.Results: Findings indicated that job stress and work-family conflict had a positive correlation with the accidental potential among employees. Moreover, we found that among the sub-scales of work-family conflict, the highest score was related to the behavioral conflict in the family (9.19). Among the stress subscales, the highest score was attributed to the job performance subscale (18.43).Conclusion: The results show that the increased work stress and work-family conflict lead to an increase in the level of incidence. Therefore, a psychologist should be present in the work and training environments to control and manage the stress, divide the family and work duties, address these problems, and reduce the incidents.
Mutation yellow in agouti loci prevents age-related increase of skeletal muscle genes regulating free fatty acids oxidation
Authors: Piskunova Y. V. , Kazantceva A. Y. , Baklanov A. V. , Bazhan N. M.
Published: December 2018

The lethal yellow mutation in agouti loci (Ay mutation) reduces the activity of melanocortin (MC) receptors and causes hyperphagia, obesity and type two diabetes mellitus in aging mice (Ay mice). It is unknown if changes in distinct elements of the metabolic system such as white adipose tissue (WAT) and brown adipose tissue (BAT), and skeletal muscle will manifest before the development of obesity. The aim of this work was to measure the relative gene expression of key proteins that regulate carbohydrate-lipid metabolism in WAT, BAT and skeletal muscle in Ay mice before the development of obesity. C57Bl/6J mice bearing a dominant autosomal mutation Ay (Ay /a mice) and mice of the standard genotype (a/a mice, control) have been studied in three age groups: 10, 15 and 30 weeks. The relative mRNA level of genes was measured by real-time PCR in skeletal muscles (uncoupling protein 3 (Ucp3) and carnitine palmitoyl transferase 1b (Cpt1b) (free fatty acids oxidation), solute carrier family 2 (facilitated glucose transporter), member 4 (Slc2a4) (glucose uptake)), in WAT lipoprotein lipase (Lpl) (triglyceride deposition), hormone-sensitive lipase (Lipe) (lipid mobilization), and Slc2a4 (glucose uptake)), and in BAT: uncoupling protein 1 (Ucp1) (energy expenditure). The expression of Cpt1b was reduced in young Ay mice (10 weeks), there was no transient peak of transcription of Cpt1b, Ucp3 in skeletal muscle tissue and Lipe, Slc2a4 in WAT in early adult Ay mice (15 weeks), which was noted in а/а mice. Reduction of the transcriptional activity of the studied genes in skeletal muscle and white adipose tissue can initiate the development of melanocortin obesity in Ay mice.
Una lectura crítica sobre el concepto de “extractivismo” en el marco de los procesos de acumulación
Authors: Galafassi Guido Pascual , Riffo Lorena Natalia
Published: December 2018

Para percibir y entender toda la complejidad del proceso de relación sociedad-naturaleza-territorio es necesario tomar el proceso extractivo, en tanto integrante de un complejo entramado de relaciones, operaciones y procesos que adoptan las formaciones sociales en tanto estrategia de producción, distribución y reproducción de los recursos (naturales y humanos), los beneficios y el trabajo. Por esto, resulta indispensable pensar al proceso extractivo (en tanto práctica), más que al extractivismo (en tanto fenómeno sustantivo) como una etapa del proceso total de la acumulación. Y como etapa, va sufriendo –al igual que el proceso de acumulación– cambios y transformaciones a lo largo del tiempo, pero siempre en relación con los principios básicos que implican tanto la explotación del trabajo como de la naturaleza.
Restricted Maximum Likelihood Method As An Alternative Parameter Estimation in Heteroscedastic Regression
Authors: Masrokhah Dwi , Soehono Loekito Adi , Astutik Suci
Published: December 2018

Students are part of the community who have an income. The income of students are pocket money, scholarships, part-time jobs and so forth. They are trying to become trendsetter in get dress and . The consumption patterns are very influential in behavior of saving. If the savings increases not only the public funds will increase but also the investment. If the investment increases the economic growth has also increased. The purpose of this research is to estimate multiple regression parameters using REML methods in modeling the student’s saving in Faculty of Mathematics and Natural Science, Brawijaya University. The variables used were X_1= The student’s age (years), X_2= The amount of income of student’s parent (thousand rupiah), X_3= The amount of student’s pocket money (thousand rupiah), X_4= The amount of student’s additional income (thousand rupiah), X_5= The amount of student’s consumption (thousand rupiah) and Y= The amount of student’s saving (thousand rupiah).REML method can overcome heteroscedasticity error variance and unbiased estimator. The model of student’s saving is using REML method as follows:Y ̂_i= -1855,66 +121,5 X_1+0.0098X_2+0.0524 X_3+0.5587 X_4-0.5851X_5Student’s saving affected by: student’s age (years), the amount of student’s additional income (thousand rupiah), and the amount of student’s consumption (thousand rupiah).
On The Metric Dimension of Some Operation Graphs
Authors: Marsidi Marsidi , Agustin Ika Hesti , Dafik Dafik , Alfarisi Ridho , Siswono Hendrik
Published: December 2018

Let  be a simple, finite, and connected graph. An ordered set of vertices of a nontrivial connected graph  is  and the -vector  represent vertex  that respect to , where  and  is the distance between vertex  and  for . The set  called a resolving set for  if different vertex of  have different representations that respect to . The minimum of cardinality of resolving set of G is the metric dimension of , denoted by . In this paper, we give the local metric dimension of some operation graphs such as joint graph , amalgamation of parachute, amalgamation of fan, and .
Simulation Study The Implementation of Quantile Bootstrap Method on Autocorrelated Error
Authors: Saputri Ovi Delviyanti , Yanuar Ferra , Devianto Dodi
Published: December 2018

Quantile regression is a regression method with the approach of separating or dividing data into certain quantiles by minimizing the number of absolute values from asymmetrical errors to overcome unfulfilled assumptions, including the presence of autocorrelation. The resulting model parameters are tested for accuracy using the bootstrap method. The bootstrap method is a parameter estimation method by re-sampling from the original sample as much as R replication. The bootstrap trust interval was then used as a test consistency test algorithm constructed on the estimator by the quantile regression method. And test the uncommon quantile regression method with bootstrap method. The data obtained in this test is data replication 10 times. The biasness is calculated from the difference between the quantile estimate and bootstrap estimation. Quantile estimation methods are said to be unbiased if the standard deviation bias is less than the standard bootstrap deviation. This study proves that the estimated value with quantile regression is within the bootstrap percentile confidence interval and proves that 10 times replication produces a better estimation value compared to other replication measures. Quantile regression method in this study is also able to produce unbiased parameter estimation values.
Dépenses et utilisation de soins de santé: Une revue de littérature théorique et empirique
Authors: Youness Jouilil , Houda Lechheb , Hicham Ouakil
Published: December 2018

This research paper will review the literature on both important theoretical and empirical studies in health microeconomics. For this purpose, the first part defines the health insurance scheme and its main objectives. The second part presents the theoretical framework of the health demand, in particular the effect of health insurance on the consumption of health care. Part III presents examples of previous empirical studies that have examined the effect of coverage by a health insurance scheme. The last paragraph presents the role of the other dimensions and their effects on the individual demand for health care. More specifically, this paper aims, among other things, to answer these questions. Does health insurance improve the state of health? How does it affect health expenditure? What are the problems of setting up comprehensive medical coverage? What is the case for other socioeconomic and sociodemographic and socio-cultural variables? It has been found from the analysis that there is a strong relationship between insurance and access to care. This observation has been confirmed through a synthesis of most of the work dealing with this issue.
Evaluación de la cosecha de plantas seleccionadas de henequén (Agave fourcroydes Lem) y propagadas in vitro
Authors: González Gerardo , Alemán Silvia , Saavedra Hilter Figueroa , Diéguez Arisdorgan , Herrera Ramiro
Published: December 2018

This paper focuses on the establishment of a system of in vitro cloning of henequen, of which the behavior of these plants in production conditions is unknown. With the objective of evaluating the agricultural yields in selected henequen and plants propagated in vitro, five harvests were carried out during the years 2005 to 2009. In the five harvest, the yields in fiber (tn/ha) were higher in the vitroplantas in regards to conventionally propagated plants. The first harvest was done three years after the plantation was carried out. In all crops, line 4 statistically surpassed lines 1 and 9 in terms of the fibre content, which showed a greater productive potential. The histological characterization of these plants showed a greater number of vascular bundle and strands of fibers in the vitroplants with regard to plants multiplied by the conventional method. This, however, showed a significant correlation with more fibre content in the first.
Importance Des Produits Forestiers Non Ligneux Medicinaux D’origine Vegetale Et Impacts Des Activites Anthropiques Sur Leur Durabilite Dans Le Sud-Ouest De La Republique Centrafricaine
Authors: Zima Guy Gildas , Mialoundama Fidèle , Yangakola Jean Michel , Kossa Innocent
Published: December 2018

The forest in the south-west of the Central African Republic has enormous potential for non-timber forest products (NTFPs) of plant origin. The objective of this study is to identify the medicinal value of these NTFPs of plant origin with high health potential and the effects of human activities on their sustainability. The study was carried out in 09 villages in the intervention zone of the Kadéi Forestry Company. From various methodological approaches (ethno botanical survey, participant observation, inventory technique), data were collected, processed and analysed. From the results obtained 91 non-wood medicinal plant species belonging to 29 families and to one large systematic group, the Magnoliophytes were identified. These species represent a means of therapeutic remedies used by 91% of surveyed populations to treat many diseases, symptoms and infections. Tree barks (43.26%) and leaves (39.21%) are the most commonly harvested organs. The variables collected related to the types of uses allowed to identify 19 priority NTFPs medicinal and underline the process of degradation of 7 important NTFPs. This degradation is mainly due to the way in which the natural resource is harvested, causing a large number of non- woody medicinal plant species to become rare. The definition of strategies based on ecological and socioeconomic harvesting techniques of NTFPs are solutions to ensure sustainable management of these products for the benefit of future generations.
Evaluación de las pérdidas de arroz en la mini cosechadora LOVOL AF-100 (Serie 0) en la Granja Agrícola Arrocera “Bartolomé Masó Márquez”
Authors: Espinosa Benjamín Gabriel Gaskins , Socarrás Idalberto Macías , Pompa Ernesto Reyna , Reyes Miguel Bolívar Zamorano , Amat Antonio Luis Barrera
Published: December 2018

The investigation, refers to the Agricultural Farm of Rice "Bartolome Maso Marquez", located in the municipality of Yara, province of Granma, is dedicated to the production of rice, the objective is based on the total losses of the grains and the system of the machine, The quality of the harvested product is also evaluated, using the LOVOL-AF 100 (Series 0) mini harvester. The combined losses were 5.98%; I found above the parameters set by the manufacturer of 5%; There are significant differences between the losses in the different parts of the combination, with a better performance in the 1.62% sieve, followed by agitation with 2.03%, in the pre-harvest the losses were 3.5% much higher than those established, of 1 %. ; The content of impurities in the harvested mass reached 13%, higher than the established in 30%, the concept of losses of the combine in total reached 23 920 t of clean rice, which represents the consumption of rice of 322 222 people in one year.
Profil épidémiologique des maladies cardiovasculaires dans la Ville de Meknès (Maroc)
Authors: Ghazi Ibrahim El , Berni Imane , Menouni Aziza , Kestemont Marie-Paule , Amane Mohammed , Jaafari Samir El
Published: December 2018

Introduction: In Morocco, very little published work has focused on cardiovascular diseases. As a result, the main objective of this research is to evaluate the epidemiological profile of cardiovascular diseases in patients who are hospitalized and treated in the cardiology department of Mohammed V Hospital, Meknes (Morocco). Methods: This is a retrospective descriptive and analytical study of 1112 patients admitted to this department over a fouryear period (from January 1, 2011 to December 31, 2014). Results: 54.49 % of patients were women and the most affected age group was 45-64 years old (42.08 %) (p < 0.001). The most common pathologies among hospitalized patients were: ischemic heart disease which represented the first cause of hospitalization with 341 cases corresponding to 30.66 %, followed by heart failure (20.59 %). Ischemic heart disease was more common in men (p = 0.05) while women were more affected by high blood pressure (p = 0.0096), heart failure (p = 0.06) and venous thrombosis (p < 0.05). Conclusion: Cardiovascular pathologies represent a real health and socio-economic problem for families and health facilities. The frequency and severity of these diseases should prompt us to do further research on this topic to find the most plausible solutions to reduce negative impacts.
RESCISÃO FRAUDULENTA: ABORDAGEM SOBRE O SAQUE DO FUNDO DE GARANTIA DO TEMPO DE SERVIÇO
Authors: Hees Carlos Alexandre , Da Silva Tamires Gomes
Published: December 2018

O Fundo de Garantia do Tempo de Serviço, criado no governo do Presidente Humberto de Alencar Castelo Branco, em 13 de setembro de 1966, entrou em vigor no Brasil onde até então era adotado o instituto da estabilidade, que possibilitava ao trabalhador que completasse 10 anos de trabalho na mesma empresa, uma indenização equivalente a um salário mínimo por ano trabalhado, em caso de demissão imotivada. O FGTS é uma conta vinculada, utilizada pelo empregador, para a utilização do empregado nas hipóteses previstas em lei, e foi inicialmente delegado ao Banco Nacional da Habitação. Com a sua extinção pelo Decreto-Lei nº 2.291, em 21 de novembro de 1986, sua administração passou à Caixa Econômica Federal. Hoje compete ao Ministério do Trabalho e Emprego a fiscalização e apuração das contribuições, bem como a aplicação das multas e demais encargos devidos. Sobre esse assunto, existe um grande debate, pois a Consolidação das Leis Trabalhistas, não veda o saque do FGTS ao titular que é demitido e logo após recontratado pela mesma empresa, contudo a Portaria do MP-Trabalhista, nº 384/92, considera fraudulenta a rescisão seguida de recontratação ou permanência do trabalhador em serviço, quando ocorrida dentro dos 90 dias subsequentes à data que formalmente a rescisão se operou. Assim, surge a seguinte indagação: Qual o entendimento atual sobre o saque do FGTS, nos casos em que o titular é recontratado pela mesma instituição num período inferior a 90 dias da demissão? Tal procedimento é visto como fraudulento, não só em razão do fracionamento do vínculo de emprego, mas também em decorrência da diminuição dos recursos do FGTS, que são utilizados pelo governo para construção de habitações populares, obras de saneamento urbano, transportes urbanos e infraestrutura.
LIBERDADE SEM IGUALDADE: AS MINORIAS RELIGIOSAS NA ARGENTINA
Authors: Vives Juan Martin
Published: December 2018

A relação entre o Estado argentino e as igrejas e outras comunidades religiosas é uma questão complexa. Embora a constituição argentina reconheça a liberdade religiosa para todas as pessoas, ao mesmo tempo, concede um status privilegiado à Igreja Católica. Neste artigo, o autor argumenta que essas cláusulas são contraditórias e, portanto, a Argentina deve avançar para a separação da Igreja e o Estado. Além disso, o Estado deve escolher entre os modelos de neutralidade e de cooperação. Na primeira parte do artigo, analisa-se o modelo das relações Igreja-Estado na Argentina. Propõe-se primeiro uma tipologia, para então analisar qual categoria corresponde ao modelo argentino. Depois as consequências desse modelo para a liberdade religiosa são abordadas. Na segunda parte do artigo, essas ideias são aplicadas a três questões atuais na Argentina. Primeiro, o ensino da religião nas escolas públicas. Em segundo lugar, a sanção de várias leis de descanso dominical obrigatório. Finalmente, a mais recente lei de liberdade religiosa é brevemente comentada. Em todas essas questões, o autor compara as perspectivas do modelo de cooperação e o modelo de neutralidade. O autor conclui que o caminho para garantir o máximo grau possível de liberdade religiosa é através da neutralidade do Estado em matéria religiosa, uma vez que não pode haver plena liberdade sem igualdade.
HER2-positive breast cancer with brain metastasis, long responder to lapatinib therapy
Authors: Saggia Chiara
Published: December 2018

We report the case of a 45-year-old patient diagnosed, after four years from the initial diagnosis of infiltrating ductal carcinoma, with lymph node, hepatic, pulmonary and bone diseases deriving from HER2-positive breast cancer. While the association docetaxel + trastuzumab led to a partial response in all locations, trastuzumab maintenance treatment was witheld due to multiple brain progression. After neurosurgical surgery and panencephalic radiotherapy, the patient started a lapatinib-based therapy with partial response in all disease sites and minimal brain progression. The peculiarity of this clinical case is the long survival of a patient in excellent clinical condition and with good quality of life, even in the presence of HER2-positive diffuse brain disease. The patient, thanks to combined treatments and target therapy with lapatinib, reached a 3-year progression-free interval, despite the early brain progression during trastuzumab and a 6-year survival interval from the diagnosis of brain metastases. These data support lapatinib as an active therapeutic choice, effective and well tolerated also in the long term, in early progressing patients treated with trastuzumab, despite the presence of brain metastases (Oncology).
Patient with metastatic breast cancer, HER2-positive, trastuzumab- and pertuzumab-resistant responding to lapatinib
Authors: Cianniello Daniela , Caputo Roberta
Published: December 2018

Lapatinib is an intracellular tyrosine kinase inhibitor of EGFR (ErbB1) and HER2 (ErbB2) receptors, approved for the treatment of metastatic breast carcinoma pre-treated with anti-HER2 antibodies. We report the case of a 60-year-old woman diagnosed with metastatic breast neoplasm, HER2-positive, progressing after treatment with trastuzumab, pertuzumab and T-DM1, who obtained a regression of hepatic metastases after treatment with lapatinib-capecitabine (Oncology).
An overlooked diabetes in a relatively young patient
Authors: Inchiostro Sandro
Published: December 2018

In the second decade of the 2000s, it is still possible, in an industrial country like Italy, that relatively young people with type 2 diabetes are referred to a diabetologist with complications already underway, due to neglecting the disease for lack of awareness and for refusal to accept the disease. We report the case of a patient, referred to the diabetologist by the ophthalmologist who diagnosed severe proliferative diabetic retinopathy and bilateral macular edema (Diabetology).
Eighty-year-old diabetic patient with chronic stage IV renal insufficiency according to NKF
Authors: Percudani Carlo
Published: December 2018

The prevalence of diabetes mellitus increases markedly with age. Furthermore, advancing age is a strong risk factor for diabetic neuropathy. We report the case of a 80 year-old woman with diabetes and diabetic neuropathy (stage 4 according National Kidney Foundation ) treated first with gliclazide and then linagliptin (5 mg/die) that achieved an appropriate glycemic control according to age and general conditions. The treatment with linagliptin was also well-tolerated with no adverse events reported (Diabetology).
Renal insufficiency and linagliptin therapy: a case report
Authors: Corsi Anna , Trevisan Roberto
Published: December 2018

The presence of severe renal insufficiency in type 2 diabetes patients often challenges the diabetologist to prescribe a drug therapy, leading to a satisfactory glycemic balance with the minimal risk of hypoglycaemia. Diabetics with renal dysfunction present an increased risk of hypoglycemic episodes, and oral drugs are often ìcontraindications in these patients , especially if they are eliminated by the kidney. This last class of drugs requires a reduction in dosages to avoid the risk of prolonged hypoglycaemic episodes. In particular, in patients with severe renal insufficiency, metformin must be suspended in order to avoid the risk of lactic acidosis. Here we report the case of a young woman with type 2 diabetes, who quickly developed severe renal failure, unfortunately without remission. This case emphasizes the efficacy and safety of insulin-associated linagliptin for good glycemic control in patients with severe renal impairment, with marked reduction in hypoglycaemic episodes (Diabetology).
Dyspnea in the emergency department at night
Authors: Cosentino Nicola
Published: December 2018

Acute pulmonary embolism (PE) interferes with both blood circulation and gas exchange. Right ventricular failure due to pressure overload is considered the leading cause of death by PE. The diagnosis of PE can be difficult, as the symptoms are often non-specific (dyspnea, chest pain, pre-syncope or syncope, hemoptysis). In particular, chest pain may be typical and derive from ischemia of the right ventricle: in these cases a differential diagnosis with acute coronary syndrome or with aortic dissection is necessary. If EP is suspected, it is therefore necessary to proceed promptly to the recommended diagnostic investigations. The case of a 62-year-old smoker suffering from arterial hypertension, dyslipidemia, non-insulin-dependent diabetes and chronic ischemic heart disease is reported here, admitted to emergency room for increasing dyspnea from mild stress in the absence of trauma, prolonged bed rest or fever. In suspicion of PE, CT angiography with contrast agent was performed for the study of the arterial tree, which confirmed the diagnosis of venous thromboembolism. The patient is treated with supporting tights, unfractionated heparin, and dabigatran is subsequently started (Cardiology).