bluuebunny/crossref_metadata_2025 huggingface dataset:
Being busy, feeling poor: The scale development and validation of perceived time poverty
Authors: Zheng Xingshan , Zhang Qi , Li Xinxin , Wu Bingqing
Published: July 2022

Employees across the world feel increasingly time‐poor. The advancement of management research on time poverty has, however, been stymied by the lack of a validated measure. We thus aim to develop and validate a measure of perceived time poverty, defined as individuals' perceptions of lacking freely disposable time. We generated the initial items with an inductive approach and examined the content validity of the scale with an item‐sort task. We then recruited four separate samples from different cultures to assess the psychometric properties (i.e., factor structure, reliability, convergent validity, and discriminant validity) and nomological network of a six‐item, self‐report Perceived Time Poverty Scale (PTPS). The results provide evidence of the psychometric soundness of the newly developed PTPS. We discuss the implications of our scale development and offer suggestions for future research on perceived time poverty.
Factors and remedies for productivity and efficiency among small‐scale informal enterprises: A theoretical perspective
Authors: Takyi Godfred , Okeniyi Johnson O. , Samuel Sunday Eneojo
Published: July 2022

The growth and sustenance of firms are primarily determined by their productivity and efficiency. However, the productivity analysis has generally been skewed toward formal enterprises in the extant literature. For developing countries that characteristically have a greater share of informal employment, understanding the theoretical foundation of informal productivity and the proposed remedies could be the grounds for further research and deeper thinking for enhanced productivity. The central question of this paper is formulated on how a combined theoretical approach on the characteristics and location of firms could enhance knowledge on the hindering and promoting factors of productivity and efficiency among informal enterprises. Using the PRISMA methodology, 141 theoretical and empirical studies were reviewed, which revealed a central role of local and national governments in providing enabling infrastructure for the informal economy. It was found that factors like knowledge sharing, capitalisation, improved credit sector, geographical concentration, and decongestion of industrial clusters could promote productivity among informal producers. It, therefore, falls on various stakeholders to plan and execute policies on infrastructure, land‐use policies, tax, and credit that simultaneously lessen the inherent constraints of informality, while enhancing enablers of production.
Responsibility's Double Binds: The Reactive Attitudes in Conditions of Oppression
Authors: Ciurria Mich
Published: July 2022

Historically, philosophers have tended to see moral responsibility as a matter of having a certain metaphysical status. Strawson shifted the debate by defining responsibility as part of an interpersonal practice, but he did not discuss the relationship between interpersonal relationships and the politics of oppression. His view, in other words, was an example of ideal theory. This article adopts a non‐ideal theoretic framework to explore how ordinary responsibility practices uphold intersecting logics of oppression. It argues that the reactive attitudes function to police double binds, creating situations of oppression for marginalized groups.
More time awake after sleep onset is linked to reduced ventral striatum response to rewards in youth with anxiety
Authors: Sollenberger Nathan A. , Sequeira Stefanie , Forbes Erika E. , Siegle Greg J. , Silk Jennifer S. , Ladouceur Cecile D. , Ryan Neal D. , Dahl Ronald E. , Mattfeld Aaron T. , McMakin Dana L.
Published: July 2022

Background

Poor sleep and anxiety disorders are highly comorbid in youth, and each predicts altered ventral striatum (VS) response to rewards, which may impact mental health risk. Contrasting evidence suggests previously reported negative associations between sleep health and VS response may be stronger or weaker in youth with anxiety, indicating sensitivity to win/loss information or blunted reward processing, respectively. We cross‐sectionally examined the role of sleep in VS response to rewards among youth with anxiety versus a no‐psychiatric‐diagnosis comparison (ND) group. We expected a group*sleep interaction on VS response to rewards but did not hypothesize directionality.

Methods

As part of the pretreatment battery for a randomized clinical trial, 74 youth with anxiety and 31 ND youth (ages 9–14 years; n = 55 female) completed a monetary reward task during fMRI. During the same pretreatment window, actigraphy and diary‐estimated sleep were collected over 5 days, and participants and their parents each reported participants' total sleep problems. We examined group*sleep interactions on VS response to monetary rewards versus losses via three mixed linear models corresponding to actigraphy, diary, and questionnaires, respectively.

Results

Each model indicated group*sleep interactions on VS response to rewards. Actigraphy and diary‐estimated time awake after sleep onset predicted reduced VS response in youth with anxiety but not ND youth. Parent‐reported sleep problems similarly interacted with group, but simple slopes were nonsignificant.

Conclusions

Wake after sleep onset was associated with blunted reward response in youth with anxiety. These data suggest a potential pathway through which sleep could contribute to perturbed reward function and reward‐related psychopathology (e.g., depression) in youth with anxiety.
Spherical frame projections for visualising joint range of motion, and a complementary method to capture mobility data
Authors: Herbst Eva C. , Eberhard Enrico A. , Hutchinson John R. , Richards Christopher T.
Published: July 2022

Quantifying joint range of motion (RoM), the reachable poses at a joint, has many applications in research and clinical care. Joint RoM measurements can be used to investigate the link between form and function in extant and extinct animals, to diagnose musculoskeletal disorders and injuries or monitor rehabilitation progress. However, it is difficult to visually demonstrate how the rotations of the joint axes interact to produce joint positions. Here, we introduce the spherical frame projection (SFP), which is a novel 3D visualisation technique, paired with a complementary data collection approach. SFP visualisations are intuitive to interpret in relation to the joint anatomy because they ‘trace’ the motion of the coordinate system of the distal bone at a joint relative to the proximal bone. Furthermore, SFP visualisations incorporate the interactions of degrees of freedom, which is imperative to capture the full joint RoM. For the collection of such joint RoM data, we designed a rig using conventional motion capture systems, including live audio‐visual feedback on torques and sampled poses. Thus, we propose that our visualisation and data collection approach can be adapted for wide use in the study of joint function.
Histatin‐1 alleviates high‐glucose injury to skin keratinocytes through MAPK signaling pathway
Authors: Pan Li , Zhang Xuanfen , Gao Qiong
Published: July 2022

Background

Damage to keratinocytes and other skin cells in a high‐glucose environment has been proven to be an important reason for the poor wound healing ability of chronic diabetes mellitus. Histatin‐1 has been preliminarily proven to stimulate the wound healing process of the oral and non‐oral mucosa and has been found to be related to the activation of extracellular signal‐regulated kinase (ERK).

Aim of the Study

The purpose of this study was to investigate the effect of histatin‐1 on high‐glucose‐injured keratinocytes and the role of the Ras–Raf–MEK–ERK signaling pathway on the effect of histatin‐1 to improve diabetic wound healing.

Methods

A human keratinocyte model damaged by high glucose was constructed, cell proliferation was detected by the Cell Counting Kit‐8 assay, and cell apoptosis was detected by flow cytometry. The expression level of 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) was detected by ELISA, and the mitogen‐activated protein kinase (MAPK) signaling pathway protein expression level was detected by Western blot. C‐fos mRNA expression was detected by real‐time PCR.

Results

The results indicated that histatin‐1 promoted proliferation and reduced the rate of apoptosis and 8‐OHdG content in keratinocytes with high‐glucose injury. In addition, histatin‐1 down‐regulated MEK phosphorylation in keratinocytes with high‐glucose injury. However, with the extension of the intervention, the effect of histatin‐1 on c‐fos mRNA expression was different. At the early stage of high‐glucose injury (12 h), the expression of c‐fos mRNA was not increased in high‐glucose‐injured keratinocytes treated with histatin‐1 but then c‐fos mRNA expression was gradually upregulated.

Conclusion

Histatin‐1 could alleviate keratinocyte injury caused by high glucose levels and promoted wound healing in vitro. In addition, histatin‐1 could exert anti‐apoptotic and antioxidant damage effects under high‐glucose injury states. These effects of histatin‐1 may be related to its regulation of the MAPK signaling pathway. Therefore, these findings provide an essential theoretical basis for histatin‐1 to become a safe and effective new peptide biological agent to promote wound healing in patients with diabetes.
Multidimensional discrimination distress, controlling parenting, and parent–adolescent attachment relationships: Racial/ethnic differences
Authors: Kazmierski Kelly F. M. , Borelli Jessica L. , Rao Uma
Published: July 2022

Parents have multifaceted identities, across dimensions like race/ethnicity, gender, and class, which shape their experience of discrimination. However, little is known about how distress from such multidimensional discrimination influences parenting behavior and parent–adolescent relationships. We tested associations between mothers’ multidimensional discrimination distress and parental control (overcontrol and conditional regard) and daughters’ attachment, among 82 African American (AA), Hispanic/Latina (HL), and non‐Hispanic White (NHW) mother–adolescent daughter dyads in the United States. Additionally, we examined whether these associations vary by race/ethnicity. Mothers reported their distress due to multidimensional discrimination and adolescents reported mothers’ overcontrol, mothers’ conditional regard, and adolescents’ attachment to mothers. Across racial/ethnic groups, more multidimensional discrimination distress was associated with more maternal overcontrol. Additionally, racial/ethnic groups differed in associations between discrimination, maternal conditional regard, and adolescent attachment, such that AA mothers were buffered from the deleterious effects of discrimination on conditional regard and adolescent attachment. HL mothers were buffered from effects on adolescent attachment and conditional regard for anger expression, but not fear expression. Findings suggest that stigmatized racial/ethnic groups may rely on adaptive cultural practices to parent effectively in the face of multidimensional discrimination distress, but these resources may not be available to NHW mothers.
The role of endoplasmic reticulum stress in the pathophysiology of periodontal disease
Authors: Jiang Ming , Li Zhuoneng , Zhu Guangxun
Published: July 2022

The endoplasmic reticulum (ER) is a principal organelle for folding, post‐translational modifications and transport of secretory, luminal, and membrane proteins. ER stress is a condition induced by the accumulation of unfolded or misfolded proteins owing to a variety of physiological and pathological phenomena. To overcome the deleterious effects of ER stress, unfolded protein response (UPR) is initiated to translocate and remove the misfolded and accumulated proteins. Plenty of evidence shows the correlation between ER stress/UPR and the pathology of inflammatory disease. Periodontal disease is a chronic inflammatory disease characterized by the irreversible destruction of periodontal tissues, which associates with the onset and progress of several systemic diseases. Periodontopathic bacterium and pro‐inflammatory mediators play a pivotal role in the progress of periodontal disease. Besides, cigarette smoke has long been associated with periodontal disease. As an inflammatory disorder of the periodontium, periodontal disease is highly related to ER stress. In this review, we provide an overview of the pathophysiological effect of ER stress on periodontal disease through five aspects as follow: ER stress and periodontal tissue remodeling, including both soft tissue and hard tissue; ER stress and the inflammation; ER stress and systematic effect during the periodontal disease; last but not least, ER stress and the autophagic apoptosis in cells.
Clinical practice guidelines for the prevention of childhood obesity: A systematic review of quality and content
Authors: Gooey Michelle , Skouteris Helen , Betts Juliana , Hatzikiriakidis Kostas , Sturgiss Elizabeth , Bergmeier Heidi , Bragge Peter
Published: July 2022

Obesity in childhood is a significant global issue, and prevention is key to reducing prevalence. Healthcare providers can play an important role in the prevention of obesity. The aim of this systematic review was to identify and evaluate clinical practice guidelines (CPGs) for preventing childhood obesity with a focus on the role of medical doctors. Peer‐reviewed literature and gray literature sources were searched for CPGs published from 2010 to 2021. Eleven CPGs were identified. Quality was evaluated using the Appraisal of Guidelines for Research and Evaluation Collaboration (AGREE II) instrument; seven CPGs were higher quality and four lower quality. Recommendations within the CPGs covered three main areas: growth monitoring, maintaining a healthy weight, and managing overweight. The importance of involving the whole family and healthy lifestyle behaviors was emphasized. The majority of the CPGs rated poorly in guideline applicability highlighting the need for practical implementation tools. Although our review identified a number of CPGs relevant to the prevention of obesity for doctors working with children and their families, more research is needed to produce high‐quality meaningful and applicable CPGs to maximize uptake, implementation, and ultimately, benefit to children and their families.
Adenoid cystic carcinoma in children and young adults: A clinicopathological study of 12 cases
Authors: Xia Rong‐Hui , Zhang Chun‐Ye , Wang Li‐Zhen , Hu Yu‐Hua , Sun Jing‐Jing , Tian Zhen , Li Jiang
Published: July 2022

Objective

To investigate the clinicopathological characteristics, immunoprofile, and molecular alterations of adenoid cystic carcinoma (ACC) in children and young adults.

Materials and methods

Twelve cases of ACC were included. MYB, MYBL1, Ki‐67, type IV Collagen, Laminin, and LAMB1 expression were detected by immunohistochemistry. MYB and MYBL1 rearrangements were detected by fluorescence in situ hybridization.

Results

Among 12 patients, four were female and eight were male. Seven cases (58.3%) located in major salivary glands and eight cases (66.7%) were classified as Grade I. Ten tumors (83.3%) had collagenous and hyalinized stroma. MYB was positive in 83.3% cases, and the average Ki‐67 labeling index (LI) was 8.3%. LAMB1, type IV Collagen, and Laminin were positive in 91.7%, 66.7%, and 58.3% cases, respectively. Besides, three out of eight tumors had MYB rearrangement. Cases without MYB rearrangement were negative for MYBL1 expression and MYBL1 rearrangement. The average follow‐up time was 91.8 months. Four patients had recurrent diseases.

Conclusions

ACC in children and young adults was seen more frequently in males and major salivary glands. Most cases had ECM and hyaline stroma. Grade III tumors, higher Ki‐67 LI, negative expression of type IV Collagen, and Laminin showed a tendency of higher recurrence rate.
A Method to Visualize and Quantify the Intraosseous Arteries of the Femoral Head by Vascular Corrosion Casting
Authors: Zhang XiangNan , Deng Wei , Ju JiHui , Zhang Songqiang , Wang HongYu , Geng KaiLong , Wang DingSong , Zhang GuangLiang , Le YingYing , Hou RuiXing
Published: July 2022

Objective

To describe a method to display the three‐dimensional distribution of intraosseous arteries in the femoral head by vascular corrosion casting.

Methods

An experimental study was done to expose the intraosseous arteries of the femoral head by a microperfusion corrosion method between January 2021 and May 2021. Specimens were 23 swine femoral heads (12 female specimens and 11 male specimens, where age of swine ranged from 8 to 12 months, and the weight was approximately 150 kg). The femoral heads were microperfused with the vascular casting resin through retinacular arteries, and the bone of the femoral head was dissolved with 50% sodium hydroxide and 10% hydrochloric acid and rinsed under the microscope until the vessel casts were completely exposed. The distribution and anastomosis of the arteries in the femoral head were observed under direct vision and microscopy. The diameter of the artery in the femoral head was measured at 0.5 cm after its entry into the bone of the femoral head with a microscale under the microscope. The number of internal arteries with diameter ≥0.05 mm was counted. The number and diameter of the main trunk of the epiphyseal arteries in the femoral head between male and female swine were compared.

Results

The vascular casting specimen of the swine femoral head was successfully produced by using epoxy resin as a casting agent, and the three‐dimensional intraosseous vascular structures were clearly visible. The number of epiphyseal arteries in male and female swine was 8.55 ± 2.15 and 8.83 ± 2.15 (t = −0.31, p = 0.38), respectively. The diameters of the superior epiphyseal arteries in male and female swine were 0.35 ± 0.09 and 0.31 ± 0.08 mm (t = 1.03, p = 0.16), the diameters of the inferior epiphyseal arteries were 0.47 ± 0.05 and 0.49 ± 0.09 mm (t = −0.57, p = 0.29), and the diameters of the anterior epiphyseal arteries were 0.34 ± 0.08 and 0.33 ± 0.13 mm (t = 0.32, p = 0.37). There was no significant difference in the number and diameter of the main trunk of intraosseous arteries between male and female swine (p > 0.05). The main trunk of intraosseous arteries formed an anastomosis in the center of the femoral head. Among 23 swine femoral head samples, three types of intraosseous anastomosis were observed, including 13 (57%) posterior superior‐posterior inferior, seven (30%) posterior inferior‐anterior, and three (13%) uniform intraosseous anastomosis.

Conclusion

The microperfusion corrosion method can produce the vascular casting specimen of swine femoral head revealing the three‐dimensional structure of the intraosseous artery, which clearly shows the origin, course and branches, and diameter, as well as the anastomosis, of nutrient arteries in the femoral head. This method provides a simple and rapid technique for quantifying and visualizing intraosseous arteries.
Multi‐center Retrospective Study of Factors Affecting Perioperative Transfusion of Packed Red Blood Cells for Pelvic Fracture Patients
Authors: Xie Xiuqiao , Huang Yuanshuai , Huang Xueyuan , Gui Rong
Published: July 2022

Objective

To analyze the use of packed red blood cells (PRBCs) for patients with pelvic fracture and evaluate factors associated with PRBC transfusion for patients with pelvic fracture.

Methods

This retrospective cohort study collected 551 patients with pelvic fractures from six hospitals between September 1, 2012, and June 31, 2019. The age span of patients varied from 10 to 95 years old, and they were classified into two groups based on high‐energy pelvic fractures (HE‐PFs) or low‐energy pelvic fractures (LE‐PFs). The study's outcome was the use of PRBCs, fresh frozen plasma (FFP), and albumin. Demographic data, characteristics, laboratory tests, clinical treatment details, and clinical outcomes were compared between the two groups. Factors that were statistically associated with perioperative PRBCs in univariate analyses were included to conduct an optimal scale regression to determine the independent factors for perioperative PRBCs.

Results

A total of 551 patients were screened from six hospitals, and after inclusion and exclusion, 319 were finally included and finished the follow‐up from admission to discharge, while four patients died during hospitalization. Three hundred and nineteen patients were classified into two groups by their injury mechanisms. A total of 230/319 (72.1%) patients were classified into the HE‐PF group, and 89/319 (27.8%) patients were classified into the LE‐PF group. Patients in the HE‐PF group were transfused with 4.5 (3–8) units of PRBCs, 300 (0–600) ml of FFP, and 0 (0–30) g of albumin, while patients in the LE‐PF group were transfused with 3.5 (2–4.5) units of PRBCs, 0 (0–295) ml of FFP, and 0 (0–0) g of albumin (all P < 0.001). There were higher proportions of male patients and patients under 65 in the HE‐PF group (all P < 0.001). HE‐PF group patients were more severely injured and likely to take external fixation. The optimal scale regression revealed four significant factors associated with perioperative transfused PRBCs, which were patients on admission with hemorrhagic shock (importance = 0.283, P = 0.004), followed by fracture types identified by Tile classification (importance = 0.156, P < 0.001), hemoglobin levels below 70 g/L on admission (importance = 0.283, P = 0.004), followed by fracture types identified by Tile classification (importance = 0.156, P < 0.001), hemoglobin levels below 70 g/L on admission (importance = 0.148, P = 0.039), and methods of pelvic fixation (importance = 0.008, P = 0.026), ranked by the importance.

Conclusion

Patients with HE‐PFs had increased transfusions of PRBCs, FFP, and albumin, and hemorrhagic shock on admission, Tile classification, Hb levels, and stabilization methods were found to be associated with perioperative PRBCs.
Conceptions and the experience of friendship in underrepresented groups
Authors: Fehr Beverley , Harasymchuk Cheryl
Published: July 2022

The authors reviewed the literature on the meaning and experience of friendship for members of underrepresented groups (sexual orientation and gender diversity, race and ethnicity). It is argued that many of the variables that contribute to friendship formation among mainstream groups (found in past research) also apply to underrepresented groups (e.g., environments that bring people into contact with one another, homophily). There also are commonalities in the friendship maintenance processes of mainstream and underrepresented groups (e.g., self‐disclosure, provision of support). However, the authors' main point is that there are additional challenges and barriers that are encountered by members of sexual and gender diverse groups and racial and ethnic minorities, and the intersections of those identities, particularly when forming and maintaining friendships with people of majority status. The authors elucidate these challenges and discuss interventions for increasing the diversity of friends in people's networks. In addition, the authors identify significant gaps in the literature on the friendship worlds of diverse groups and offer directions for future research.
Research progress of PD‐L1 non‐glycosylation in cancer immunotherapy
Authors: Cao Pu , Yang Xiaoyan , Liu Daquan , Ye Simin , Yang Wei , Xie Zhizhong , Lei Xiaoyong
Published: July 2022

Cancer is the second leading cause of death among human diseases. Immunotherapy has opened a new chapter in cancer treatment. However, the emergence of immune escape mechanisms severely limited its application. The high expression of PD‐L1 on tumour cells is an important means for cancer cells to achieve immune escape via binding to PD‐1 on immune cells. Recent studies have shown that PD‐L1 expression in most cancer cells is over‐glycosylated. Glycosylation is a fundamental and extensive post‐translational modification of eukaryotic membrane‐binding proteins, which affects a variety of biological activities, including protein folding, solubility, stability and ligand‐receptor interactions. PD‐L1 glycosylation initiates in the endoplasmic reticulum (ER) and completes in the Golgi apparatus, which has a complex relationship with cancer development. Importantly, non‐glycosylated PD‐L1 attenuates protein stability and PD‐1 interactions. These processes are essential regulatory mechanisms that modulate immunosuppression and immune surveillance in cancer patients. Therefore, non‐glycosylated PD‐L1 may be a potentially promising strategy to improve the efficacy of checkpoint blockade therapy for cancer. In this review, we have described the PD‐L1 glycosylation processes and provided evidence for the role of non‐glycosylated PD‐L1 in anti‐tumour‐related signalling pathways. Furthermore, strategies for non‐glycosylation of PD‐L1 using small molecule inhibitors, gene therapy and various enzymes in the synthetic glycosylation pathway are discussed. Finally, the detection of PD‐L1 expression is enhanced by its deglycosylation, and we have summarized the development, application and clinical application potential of antibody therapies targeting PD‐1/PD‐L1 glycosylation.
Análisis de la carga fiscal asociada al impuesto de renta de las personas naturales asalariadas en Colombia, 2012-2020, con enfoque de equidad
Authors: Pérez Mejía Viviana
Published: July 2022

El Estatuto Tributario Nacional colombiano se estableció con el Decreto 649 de 1989, desde entonces y hasta el año 2020 se implementaron 16 reformas tributarias que modificaban la forma de depurar la base gravable para la determinación del impuesto de renta. Este trabajo busca evidenciar, para el período 2012-2020, cómo dichas modificaciones contribuyeron en la mejora de la equidad, analizada desde la óptica del coeficiente de GINI, y cómo se afectó la carga del impuesto de renta para las personas naturales asalariadas. La metodología comprende una aproximación teórica de la historia tanto del impuesto de renta como de la inequidad en Colombia; se revisaron también las modificaciones de las exenciones sobre la base gravable de las personas naturales asalariadas. Se realizó una simulación bajo escenarios de planeación óptima con varios niveles de ingreso. Los resultados muestran que, si bien las exenciones han disminuido ayudando a mejorar la equidad horizontal y Colombia viene bajando los índices de desigualdad, el sistema tributario requiere más progresividad en su régimen tarifario para generar mayor equidad vertical; además de enfocarse en la tributación del impuesto de renta personal.
Criptoactivos como fuente de financiamiento para pymes. El caso de Argentina
Authors: Vogt Maria Eugenia , Porporato Marcela
Published: July 2022

Las criptomonedas y sus ofertas iniciales (ICO, por sus siglas en inglés) constituyen un fenómeno reciente que ofrece financiamiento barato y seguro para pymes. La financiación mediante ICO permite llegar a inversores mundiales y provee de mayor liquidez y eficiencia el financiamiento de nuevos proyectos, simplificando y democratizando la captación de capital mediante una mayor inclusión. Este estudio explora su marco legal, la regulación financiera y el tratamiento contable usando datos de archivo. Estudios contables internacionales exponen el tratamiento contable recomendado para las distintas clases de tokens, analizando su exposición y valuación en el marco de las NIIF. Las pymes argentinas no pueden aprovechar la oportunidad debido al inadecuado marco jurídico y falta de regulación normativa del Banco Central y del organismo regulador del mercado de capitales. Ante el anonimato en las operaciones que permite la tecnología blockchain suelen presentarse situaciones de fraude, especulación y lavado de dinero. Se concluye que en este estado de incertidumbre normativa y riesgo actualmente no se pueden considerar las ICO como una fuente segura, viable y ventajosa de financiamiento para pymes argentinas.
Investigación contable: escenarios ontológicos y epistemológicos para su potencialización
Authors: Llanos Ceballos Adolfo León , Posada Orrego Orlando
Published: July 2022

La disciplina contable se hace presente en toda actividad humana; para desarrollar investigación en este campo se requieren cimientos conceptuales ubicados en tres tipos de epistemologías: regionales, evolutivas y naturalizadas. Además, para explicarla y comprenderla emergen dos marcos orientadores, el primero es el conocimiento donde se determina la realidad, y el segundo corresponde a los métodos que favorecen su acercamiento epistemológico. Precisamente, el objetivo de este artículo es solventar la dificultad relacionada con la fundamentación disciplinar, para ello, se accede a un debate reflexivo de diversos autores que posibilitan el entendimiento de los entornos sociológico, antropológico y axiológico de la profesión. Se presenta también un abordaje simbólico, reconociendo lo necesario de asumir una postura crítica y social para humanizar la contaduría pública.
Incidencia de la implementación del control interno basado en el método COSO, en la rentabilidad de las pymes del sector comercial de Guayaquil, Ecuador
Authors: Mendieta Tumbaco Ericka , Navarrete Carreño Oswaldo , Romero Molina Maritza
Published: July 2022

Este artículo busca determinar la influencia del control interno mediante la implementación del modelo COSO en la rentabilidad de las pymes del sector comercial de Guayaquil en 2019. Es un estudio de tipo descriptivo con enfoque cuantitativo. Se estimaron modelos lineales de efectos mixtos, con un muestreo por conveniencia a 124 pymes encuestadas con un cuestionario conformado por 18 preguntas; también se calculó el indicador financiero ROE. Se constató que los componentes de la metodología COSO produjeron un incremento en el ROE, siendo las actividades de control y evaluación de riesgos las de mayor participación, en contraste con el bajo efecto de información y comunicación. Se concluye que la aplicación de un control interno efectivo tiene un efecto favorable en la rentabilidad de las pymes.
La relevancia valorativa de la información financiera en Colombia. Un estudio empírico
Authors: Rico Bonilla Carlos Orlando
Published: July 2022

En el artículo se examina el efecto que tienen los ciclos económicos y el proceso de convergencia con los International Financial Reporting Standards (IFRS) en la relevancia valorativa de la información financiera de las empresas cotizantes en la Bolsa de Valores de Colombia, entre 2001 y 2020. En el análisis empírico se toma como base teórica y metodológica el Modelo de Ohlson estimado en regresiones lineales para cada año (corte transversal) a partir de Mínimos Cuadrados Ordinarios (MCO). Para el período señalado, se evidenció una influencia significativa de los importes contables del patrimonio y el resultado neto sobre el cambio en el precio de las acciones, sin embargo, esta conexión ha presentado un descenso notable desde 2012. Se encontró que en los años dónde la variación de la tasa de crecimiento del PIB per cápita fue negativa, la capacidad explicativa de las variables contables sobre las bursátiles disminuyó. Igualmente, se identificó que en la etapa de aplicación obligatoria de los IFRS no se presentó un incremento sustancial de la relevancia valorativa, situación que es pertinente estudiar con más detalle.
A pancreatic pause in breast cancer
Authors: Wong Wei
Published: July 2022

Breast cancer–derived extracellular vesicles suppress insulin release to increase systemic glucose availability.
Complete Coding Genome Sequences of Five Foot-and-Mouth Disease Viruses Belonging to Serotype O, Isolated from Cattle in Uganda in 2015 to 2016
Authors: Ahmed Zaheer , Velazquez-Salinas Lauro , Mwiine Frank N. , Vander Waal Kimberly , Rieder Elizabeth
Published: July 2022

Complete coding genome sequences of five foot-and-mouth disease virus (FMDV) serotype O strains that were isolated from the field between 2015 and 2016 showed five lineages within the EA-2 topotype circulating in four different regions (northern, western, eastern, and central) of Uganda. The genomic diversity may help in devising FMDV control strategies for Uganda.
Genome Sequence of Acinetobacter baumannii Strain SHOU-Ab01, Isolated from Chinese Giant Salamander (Andrias davidianus) Liver
Authors: Yuan Lu , Zhang Xiaoyan , Lyu Yufei , Guo Yan , Chen Jie , Wang Dongshu , Wang Liping , Wang Hengliang , Liu Xiankai
Published: July 2022

This report describes the complete genome sequence of
Acinetobacter baumannii
strain SHOU-Ab01, which was isolated from the liver of a Chinese giant salamander (
Andrias davidianus
). SHOU-Ab01 belonged to sequence type 40 (ST40), and its genome contained a circular chromosome (size, 3,891,862 bp) and two circular plasmids (sizes, 8,571 bp and 5,870 bp).
Angiotensin-Converting Enzyme 2 Potentiates SARS-CoV-2 Infection by Antagonizing Type I Interferon Induction and Its Down-Stream Signaling Pathway
Authors: Chen Jian , Liu Jian , Chen Zhilu , Peng Haoran , Zhu Cuisong , Feng Daobin , Zhang Shuye , Zhao Ping , Zhang Xiaoyan , Xu Jianqing
Published: July 2022

Efficient antiviral immune responses against SARS-CoV-2 infection play a key role in controlling the coronavirus diseases 2019 (COVID-19) caused by this virus. Although SARS-CoV-2 has developed strategies to counteract the IFN-I signaling through the virus-derived proteins, our knowledge of how SARS-CoV-2 survives through the innate antiviral mechanism remains poor.
Transcriptional Response and Plant Growth Promoting Activity of Pseudomonas fluorescens DR397 under Drought Stress Conditions
Authors: Nishu Susmita Das , No Jee Hyun , Lee Tae Kwon
Published: July 2022

Drought is a serious abiotic stress on plants as wells as the microbes that coexist with plants, which significantly lowers their fitness. The plant-bacterial interaction is an important strategy to enhance their fitness under drought.
Combing Immunoinformatics with Pangenome Analysis To Design a Multiepitope Subunit Vaccine against Klebsiella pneumoniae K1, K2, K47, and K64
Authors: Wang Zhuohao , Guo Genglin , Li Quan , Li Pei , Li Min , Zhou Lu , Tan Zhongming , Zhang Wei
Published: July 2022

Klebsiella pneumoniae
is an opportunistic Gram-negative bacterium that has become a leading causative agent of nosocomial infections. Among the numerous capsular serotypes, K1, K2, K47, and K64 are commonly associated with higher virulence (hypervirulent
K. pneumoniae
).
Performance of 22 Rapid Lateral Flow Tests for SARS-CoV-2 Antigen Detection and Influence of “Variants of Concern”: Implications for Clinical Use
Authors: Gourgeon Aurélie , Soulier Alexandre , Audureau Étienne , Khouider Souraya , Galbin Arnaud , Langlois Camille , Bouvier-Alias Magali , Rodriguez Christophe , Chevaliez Stéphane , Pawlotsky Jean-Michel , Fourati Slim
Published: July 2022

The use of lateral-flow tests (LFTs) to detect SARS-CoV-2 has expanded worldwide. LFTs detect SARS-CoV-2 viral antigen and are less sensitive than nucleic acid amplification testing (NAAT).
Compartment and Plant Identity Shape Tree Mycobiome in a Subtropical Forest
Authors: Yang Hao , Yang Zhijie , Wang Quan-Cheng , Wang Yong-Long , Hu Hang-Wei , He Ji-Zheng , Zheng Yong , Yang Yusheng
Published: July 2022

Subtropical mountain forests are widely distributed in Southern China and are characterized by high biodiversity. The interactions between plants and fungi play pivotal roles in biodiversity maintenance and community stability.
Rare case of sudden onset sensorineural hearing loss in a patient diagnosed with sarcoidosis
Authors: Wong Jeremy , Leach Laura , Chen-Xu Michael , Truman Lucy
Published: July 2022

We report the case of a woman in her 30s who was referred to the ear, nose and throat department with sudden onset left-sided sensorineural hearing loss (SNHL), left anterior uveitis and erythematous lower limb lesions with bilateral pitting oedema. Based on her symptoms, an underlying inflammatory systemic disease was suspected. Autoantibodies were negative but an X-ray and high-resolution CT scan of the chest were suggestive of sarcoidosis, which was confirmed on endoscopic bronchial biopsy. Following treatment with a course of oral steroids, the patient’s hearing has improved but she still suffers from episodes of uveitis. While immune-mediated inner ear disorders are a recognised cause of SNHL, sarcoidosis is a very rare cause. This case demonstrates the importance of screening for systemic autoimmune aetiology in SNHL and highlights the importance of an effective multidisciplinary team in the diagnosis and management of these patients.
Pacemaker lead-related endocarditis withNeisseria sicca
Authors: Locke Margaret , Smith Alexander , Epstein Laurence M , Niknam Negin , Boparai Rubina
Published: July 2022

We report the first known case ofNeisseria sicca-associated pacemaker lead endocarditis—a disease whose incidence and mortality are growing. A woman in her 70s with a history of transcatheter aortic valve replacement and pacemaker placement 7 months earlier presented with recurrent fevers. She visited the emergency department several times during the past 2 months for these fevers, and she had been given oral antibiotics for presumed urinary tract infections. Investigations revealed blood cultures growingN. sicca. Although transthoracic echocardiogram was negative, transesophageal echocardiogram showed two vegetations on the right atrial lead which suggested pacemaker lead-associated endocarditis. A complete pacemaker and lead extraction was performed, and the patient recovered completely and was discharged home to complete 6 weeks of intravenous ceftriaxone with plans for follow-up echocardiography. We hope that this case will contribute to the growing body of literature regarding device infections, thus leading to earlier identification and treatment.
Paediatric submental epidermoid cyst
Authors: Das Aparna , Trupthi M C , War Shaniah Skhembha , Varghese Ajoy Mathew
Published: July 2022

A young girl presented with an insidious onset, gradually increasing midline submental swelling of 1-year duration and pain on swallowing for 6 months. Ultrasonography of the neck suggested a hypoechoic cystic swelling of the submental region between the muscles of the floor of the mouth, with no increased vascularity. An extraoral surgical enucleation was done and a postoperative biopsy suggested an epidermoid cyst. Epidermoid cysts of the submental region are extremely rare and any midline head and neck lesion in children requires critical examination and evaluation to avoid complications. Here, we present a rare case of a paediatric submental epidermoid cyst and its clinical features and management.
SEC23Bmissense mutation-associated congenital dyserythropoietic anaemia type II in a child: a rare mimic of chronic haemolytic anaemia
Authors: Alam Md Jasim , Mandal Anusree Krishna , Mandal Subinay , Jana Jadab Kumar
Published: July 2022

We report a case of congenital dyserythropoietic anaemia (CDA) type II in a female child, which is an extremely rare cause of hereditary anaemia. The patient, still in her early childhood, presented to us with transfusion-dependent anaemia, unexplained jaundice, passage of cola-coloured urine and hepatosplenomegaly. Further investigations revealed evidence of iron overload, ineffective erythropoiesis and inadequate bone marrow response. Bone marrow aspiration study demonstrated dyserythropoiesis and findings typical of CDA type II. Targeted exome genome sequencing was done and identified heterozygous missense mutation of theSEC23Bgene. CDA, being clinically similar to other more prevalent causes of anaemia, should be kept in mind especially when the common causes have already been ruled out.
Association between university students’ two-staged health screening and student health care utilisation: register based observational study
Authors: Seilo Noora , Paldanius Susanna , Autio Reija , Koskela Tuomas , Kunttu Kristina , Kaila Minna
Published: July 2022

Objectives

The aim of this study was to explore how university students’ participation in a two-staged health screening at the beginning of university studies associates with student health care utilisation in a 6-year follow-up.

Design

Nationwide, observational, register-based cohort study with a 6-year follow-up.

Setting

Student health care in Finland. Finnish Student Health Service (FSHS) provides statutory student health services to university students in Finland. The two-staged health screening of FSHS includes the electronic health questionnaire (eHQ) provided annually to university entrants and a subsequent health check, when necessary, based on students eHQ response.

Participants

A national cohort of university entrants from the 2011–2012 academic year (N=15 723) was assessed. After exclusions the study population consisted of 12 972 students, n (female)=7368, n (male)=5604.

Outcome measures

The primary outcome measures were students’ health service utilisation pattern obtained by clustering analyses method and the students’ participation in different stages of the health examination process.

Results

Four distinguishable health care utilisation patterns were identified: (1) constant low use, (2) constant high use, (3) increasing use and (4) decreasing use. The students’ OR for belonging to the constant high use group was significantly higher among females (OR 4.0, 95% CI 3.5 to 4.6) and students who attended the health check (OR 4.7, 95% CI 3.9 to 5.6).

Conclusions

Participating in the two-staged health screening was associated with increase in health care utilisation. The process detects students with health problems.
Association between terminal pleural elastance and radiographic lung re-expansion after therapeutic thoracentesis in patients with symptomatic pleural effusion: a post-hoc analysis of a randomised trial
Authors: Lester Michael , Maldonado Fabien , Rickman Otis B , Roller Lance J , Avasarala Sameer K , Katsis James M , Lentz Robert J
Published: July 2022

Objectives

Recurrent symptomatic effusions can be durably managed with pleurodesis or placement of indwelling pleural catheters. Recent pleurodesis trials have largely relied on lung re-expansion on post-thoracentesis radiograph as an inclusion criterion rather than pleural elastance as determined by manometry, which is an important predictor of successful pleurodesis. We investigated the association between lung re-expansion on post-pleural drainage chest imaging and pleural physiology, with particular attention to pleural elastance over the final 200 mL aspirated.

Design

Post-hoc analysis of a recent randomised trial.

Setting and participants

Post-results analysis of 61 subjects at least 18 years old with symptomatic pleural effusions estimated to be at least of 0.5 L in volume allocated to manometry-guided therapeutic thoracentesis in a recent randomised trial conducted at two major university hospitals in the USA.

Primary outcome measures

The primary outcome was concordance of radiographic with normal terminal pleural elastance over the final 200 mL aspirated. We label this terminal elastance ‘visceral pleural recoil’, or the tendency of the maximally expanded lung to withdraw from the chest wall.

Results

Post-thoracentesis chest radiograph and thoracic ultrasound indicated successful lung re-expansion in 69% and 56% of cases, respectively. Despite successful radiographic lung re-expansion, visceral pleural recoil was abnormal in 71% of subjects expandable by radiograph and 77% expandable by ultrasound. The sensitivity and positive predictive value of radiographic lung re-expansion for normal visceral pleural recoil were 44% and 24%, respectively.

Conclusion

Radiographic lung re-expansion by post-thoracentesis chest radiograph or thoracic ultrasound is a poor surrogate for normal terminal pleural elastance. Clinical management of patients with recurrent symptomatic pleural effusions guided by manometry rather than post-thoracentesis imaging might produce better outcomes, which should be investigated by future clinical trials.

Trial registration number

NCT02677883; Post-results.
Identifying non-communicable disease multimorbidity patterns and associated factors: a latent class analysis approach
Authors: Puri Parul , Singh Shri Kant , Pati Sanghamitra
Published: July 2022

Objective

In the absence of adequate nationally-representative empirical evidence on multimorbidity, the existing healthcare delivery system is not adequately oriented to cater to the growing needs of the older adult population. Therefore, the present study identifies frequently occurring multimorbidity patterns among older adults in India. Further, the study examines the linkages between the identified patterns and socioeconomic, demographic, lifestyle and anthropometric correlates.

Design

The present findings rest on a large nationally-representative sample from a cross-sectional study.

Setting and participants

The study used data on 58 975 older adults (45 years and older) from the Longitudinal Ageing Study in India, 2017–2018.

Primary and secondary outcome measures

The study incorporated a list of 16 non-communicable diseases to identify commonly occurring patterns using latent class analysis. The study employed multinomial logistic regression models to assess the association between identified disease patterns with unit-level socioeconomic, demographic, lifestyle and anthropometric characteristics.

Results

The present study demonstrates that older adults in the country can be segmented into six patterns: ‘relatively healthy’, ‘hypertension’, ‘gastrointestinal disorders–hypertension–musculoskeletal disorders’, ‘musculoskeletal disorders–hypertension–asthma’, ‘metabolic disorders’ and ‘complex cardiometabolic disorders’. Additionally, socioeconomic, demographic, lifestyle and anthropometric factors are significantly associated with one or more identified disease patterns.

Conclusions

The identified classes ‘hypertension’, ‘metabolic disorders’ and ‘complex cardiometabolic disorders’ reflect three stages of cardiometabolic morbidity with hypertension as the first and ‘complex cardiometabolic disorders’ as the last stage of disease progression. This underscores the need for effective prevention strategies for high-risk hypertension group. Also, targeted interventions are essential to reduce the burden on the high-risk population and provide equitable health services at the community level.