bluuebunny/crossref_metadata_2025 huggingface dataset:
Keteladanan Spiritual dalam Kepemimpinan Yosua: Pengaruhnya dalam Meningkatkan Ketekunan Rohani dalam Konteks Kepemimpinan
Authors: Tamba Gerbin , Nainggolan Sarwedy , Sinaga Janes , Sinambela Juita Lusiana
Published: December 2023

This study aims to analyze the concept of spiritual example in Joshua's leadership and its impact on increasing spiritual perseverance in the context of leadership. This study uses a qualitative method with a literature review approach to explore the concept of spiritual example in Joshua's leadership and how this concept influences the increase of spiritual perseverance in the context of leadership. Through analysis of religious, theological, and leadership literature, this study reveals that Joshua, an ancient leader in the Bible story, represents a spiritual role model in leadership roles. Joshua's leadership characteristics that reflected spiritual values, such as integrity, firm faith, and commitment to moral goals, had a positive impact in guiding the Israelites and strengthening spiritual perseverance in the face of challenges. This study describes how Joshua's spiritual example inspires and guides community members to follow the spiritual values he exhibits. Furthermore, the implication of the concept of spiritual example in leadership is the potential to strengthen the moral and ethical foundations in leadership roles. This research also shows the importance of the spiritual dimension in forming meaningful and authentic leadership characters in dealing with modern dynamics. The results of this study have significant practical implications for contemporary leaders. An understanding of the concept of spiritual example in Joshua's leadership can help leaders integrate spiritual values into their leadership practices. As such, this research makes a valuable contribution to understanding the relationship between spiritual example, spiritual perseverance, and meaningful leadership in this complex world.
LEUCEMIA MIELOIDE CRÔNICA: UMA REVISÃO DA LITERATURA
Authors: Silva Bruna , Lopes Brendha Queiroga , Batista Giulia Stein , Bueno Fernanda De Sousa
Published: December 2023

A LMC (Leucemia Mieloide Crônica) é caracterizada pela presença do cromossomo Filadélfia, devido 1 à sua translocação. Na leucemia, as células sanguíneas doentes se formam e interrompem a produção de células saudáveis da medula óssea, diminuindo seu número normal. Os pacientes com LMC têm uma superprodução de glóbulos brancos e geralmente apresentam uma evolução lenta no crescimento das células doentes ao longo do tempo. Uma estimativa aproximada de casos na população é de cerca de 15% em adultos, considerando que existem outros tipos de leucemia, essa porcentagem tem um peso muito maior, mas em crianças a incidência é considerada rara, correspondendo a cerca de 10% de todos os casos de LMC.
ASPECTOS CONTEMPORÂNEOS DA CIDADANIA CORPORATIVA: UM CAMINHO PARA A AUTORREGULAÇÃO
Authors: Pontes Ílina Cordeiro de Macedo
Published: December 2023

O presente artigo tem como objetivo tratar aspectos atuais da cidadania corporativa e seu papel no surgimento da autorregulação por parte de empresas privadas. A realidade contemporânea de atuação dos cidadãos indivíduos é bastante limitada. Há uma disseminação de apatia política que abarca a maior parte dos cidadãos. Nesse mesmo contexto, as empresas se apresentam cada vez como atores políticos perante a sociedade. Entretanto, há grandes divergências doutrinárias quanto à possibilidade de as empresas serem consideradas, de fato, cidadãs. Nesse sentido, o trabalho envereda por diversas teorias, contra e a favor, da transposição da categoria de cidadania para o âmbito corporativo. Em face da ausência de uma pacificação doutrinária a respeito do conceito, averiguou-se os aspectos práticos a ele conectados, como a responsabilidade social corporativa e o compliance. Verificou-se, assim, que ambos apontam para um caminho de autorregulação desses entes privados
ANÁLISE DA FALTA DE MEDICAMENTOS BÁSICOS NA CENTRAL DE ABASTECIMENTO FARMACÊUTICO DO MUNICÍPIO DE RIO MARIA, PARÁ
Authors: Sousa Alefy Gabriel Silva , Miranda Caroline Silva
Published: December 2023

O objetivo findado é analisar através de um estudo de caso a falta de medicamentos de diabetes e hipertensão no Centro De Abastecimento Farmacêutico do município de Rio Maria – Pará. Se baseando na metodologia MRP para a análise do controle padrão e estoque dos medicamentos, sincronizando a demanda e a saída, através da coleta e análise dos dados no prazo de seis meses do ano de 2022 no CAF do município, sendo possível prever o risco da falta desses medicamentos essenciais para a manutenção da vida dos pacientes.
TEORIA E EPISTEMOLOGIA DA HISTÓRIA: NEOPOSITIVISMO, COMPREENSÃO HERMENÊUTICA E PÓS-MODERNIDADE
Authors: Ramos Neto João Oliveira , Rodrigues Fernando da Rocha
Published: December 2023

A epistemologia da História é um campo da filosofia que explora os desafios relacionados à obtenção de conhecimento histórico. Este texto discute várias abordagens para a compreensão do passado e os obstáculos inerentes a essa busca. Em conclusão, o conhecimento histórico não busca alcançar uma verdade absoluta, mas é um processo contínuo de questionamento e interpretação. A compreensão do passado é complexa e exige um diálogo constante entre o historiador e seu objeto de estudo.
Optimization of Cooking Time, Toasting Temperature and Tempering Time to Improve Physical Qualities of Corn Flake from Maize
Authors:   Amhara Regional Agricultural Research Institute, Demissew Ayalew , Temesgen Kiber ,   Amhara Regional Agricultural Research Institute, Meresa Ayenew ,   Amhara Regional Agricultural Research Institute
Published: December 2023

In this study processing conditions of corn flake were determined to produce optimum corn flake characteristics such as untoasted flake thickness, low bulk density, high water absorption index and acceptable sensory qualities for maize variety of BH-540. It was also found that the effect of cooking time, toasting temperature, and tempering time most importantly influence physicochemical properties of processed corn flakes. The optimal processing conditions of corn flake form maize variety of BH-540 was found as cooking time (46 min), tempering time (71 min) and toasting temperature of 181oC. Physicochemical properties such as untoasted flake thickness, toasted flake thickness, bulk density and water absorption capacity of optimally processed corn flakes were1.76 mm, 2.41mm, 1.08g/mL and 1.56mL/g respectively.
Կոլեկտիվ անվտանգության տարածաշրջանային կազմակերպությունների առանձնահատկությունները. Քաղաքագիտական վերլուծություն ՆԱՏՕ-ի և ՀԱՊԿ-ի օրինակով / Peculiarities of regional collective security organizations: Politological case study of NATO and CSTO
Authors: Kocharyan T. T.
Published: December 2023

Comparative analysis of alliance models of regional collective security systems, carried out at the level of theoretical developments, including corresponding official documents of leading states and concepts, as well as performance of NATO and CSTO, enables drawing out some structural principles, typical of such models, and acitivity mechanisms of such organizations with specific peculiarities, inherent to particularly NATO and CSTO. More specifically, the principle of indivisibility of security, meaning that the security of one state ought not to be gained on another state’s expense, is underlying the idea of collective security. The willingness of each of the members to view any aggression against one as aggression against all the members, and the exclusion of power solution of any contradictions within the given organization are a basic term for shaping an alliance model of collective security.

NATO was established as a counterweight to the Socialist Camp, setting up in Eastern Europe. The goal for this union of states within the NATO system was to ensure the military security of separate states on account of collective military, political and economic power of the Organization as a whole, i. e., the corporate power of all of its members. At present, NATO at times undertakes functions, not provided by its founding treaty. The USA, being nowadays the world’s leading power, steps up as the leader of NATO, this greatly providing for the Alliance’s strength and authority in the international relations system.

Though CSTO has been set with the same goals as NATO, but it remains purely regional organization with limited area of responsibility. In this regard, in the course of the years the Organization has carried out only one peacemaking operation (Kazakhstan, 2022). CSTO is characterized by certain specific features, which allow for a number of objective and subjective factors hindering its efficient performance. Thus, for instance, the membership of Kazakhstan and Kyrgyzstan in CSTO, while being at the same time members of the Organisation of Islamic Cooperation and Organization of Turkic States, has led to the fact that in the CSTO framework, Armenia has practically cooperated and still cooperates in the bilateral format only with Russia (Belarus “having leant towards” Islam). No wonder that CSTO has to some degree ignored numorous acts of aggression Azerbaijan carried out against Armenia, and avoided real in-depth political assessments of these acts. As a main hindrance for CSTO’s efficient performance can be viewed the fact that the titular nations of the majority of members didn’t have their own statehood, and lacked any experience in shaping international realtions before.
Do Employee-oriented and Task-oriented Leadership Behaviors of Secondary School Heads matter for their Teachers Job Satisfaction?
Authors: Shafiq Farah , Rashid Yamima , Lodhi Huma
Published: December 2023

The major purpose of this study was to identify the type of behavior leaders commonly use in secondary schools as well as the effect of that behavior on teachers’ job satisfaction. For having a clearer picture, there were two categories of behaviors investigated such as employee-centered behavior of leader and task-centered behavior of leadership.  In this way, two different questionnaires ‘the Leadership behavior description questionnaire (LBDQ XII)’ and ‘teachers’ job satisfaction questionnaire (TJSQ)’ were adapted and distributed among teachers for knowing their perception. 200 participants were chosen from the area of Lahore by using the convenience sampling technique. The survey questionnaire has divided into three sections: one comprises demographic information, while the other two cover statements about leader behaviors and job satisfaction. With the help of Statistical Package for Social Sciences (SPSS) 21.0 IBM, the gathered data were scrutinized. Independent sample T.test and Pearson’s correlation tests were applied for attainment of results. With the help of computed data, it can be inferred that there is a substantial link between heads' employee-oriented and task-oriented leadership conduct and teachers' satisfaction regarding their jobs while task-oriented leadership behavior being the most common inside institutions.
Orthographic Errors Among High School Students: A Case Study of Toba Tek Singh, Punjab, Pakistan
Authors: Ammara Talat  , Dr. Wasim Hasan  , Gulraiz Qadir Gulfam
Published: December 2023

Second language learning (SLL) involves learning a non-native language, including reading, writing, and listening skills. Students often commit orthographic errors, which are unconsciously or inadvertently written without proper spelling. This paper investigates the main causes of spelling errors among Pakistani English Language Learners at school levels specifically targeting high schools in the rural area of Punjab, Pakistan, known as Toba Tek Singh. This study uses a questionnaire and test-taking method with a sample of 300 girls and boys students from 9th and 10th standard through systematic sampling in order to collect and analyze data. The current paper discusses the different types of orthographic errors and investigates their reasons. The main premise of the current study was to find out the main causes of spelling errors among Pakistani English Language Learners at the School level. This leads us to a logical conclusion of the main causes of the poor spelling errors being made by the students. This makes us able to put suitable suggestions The study identifies the role of teachers in correcting these errors, with suggestions serving as a guide for teachers and recommendations for future research. Teachers play a crucial role in correcting these errors.
Role of Nudges in Personal Hygiene Habits among Early Graders
Authors: Iqbal Mazhar , Dr. Muhammad Samiullah  , Aslam Sadia
Published: December 2023

The main objective of the study is to find the role of nudges in personal hygiene habits (PHH) among early graders. The descriptive research was carried out on a sample of 226 ECE students from public high and higher secondary schools by using mixed method research design. Personal hygiene habits knowledge and practices of students were observed in with nudges and without nudges schools. The data were analyzed by using SPSS. The findings showed that hygiene nudges are playing key role in shaping personal hygiene habits among early graders. Therefore, it is recommended to install hygiene nudges in the schools country wide to improve personal hygiene habits practices.
Pengaruh budaya organisasi dan komitmen organisasi terhadap kinerja karyawan instalasi rawat inap medik rsup sanglah denpasar
Authors: Menuh Ni Nyoman , Saraswastini Ni Kadek
Published: December 2023

The purpose of this study was to determine and analyze the influence of organizational culture and organizational commitment on employee performance at the Inpatient Medical Installation at Sanglah Hospital Denpasar. The types of data used in this study are qualitative data and quantitative data, with data sources namely primary data and secondary data. Methods of data collection is done by distributing questionnaires to respondents. The results showed that organizational culture had a positive and significant effect on employee performance, organizational commitment had a positive and significant effect on employee performance, organizational culture and organizational commitment simultaneously had a positive and significant effect on employee performance at the inpatient medical installation at Sanglah Hospital Denpasar.
Perioperative cutaneous complications in an elderly patient due to inappropriate use of a forced-air warming device and underbody blanket: a case report
Authors: Kim Myounghun , Lee Soo Jee , Choi Beomseok , Lee Geunho , Ki Seunghee
Published: December 2023

Forced-air warming is commonly utilized to prevent perioperative hypothermia. Underbody warming blankets are often employed to secure a larger area for patient warming. While forced-air warming systems are generally regarded as safe, improper usage poses a risk of cutaneous complications. Additionally, the influence of underbody blankets on cutaneous complications remains uncertain. We present a case of cutaneous complications resulting from the improper utilization of a forced-air warming device and an underbody blanket. A 79-year-old man presented to the hospital for robotic proctectomy under general anesthesia. The surgery lasted for 7 hours, and the forced-air warming device with underbody blanket operated continuously for 5 hours intraoperatively. The surgery was completed without any incidents. However, first-degree burns on the patient’s back, along with superficial decubitus ulcers on his right scapula, were observed after surgery. To prevent cutaneous complications, clinicians must adhere to the manufacturer's guidelines when utilizing a forced-air warming system. Compared to overbody blankets, underbody blankets have limitations in monitoring cutaneous responses. Ensuring patient safety requires selecting an appropriate blanket for scheduled operations.
Relações laborais sob pressão na Europa: contribuições para a teoria da resiliência social
Authors: Calado Alexandre , Capucha Luís , Wódz Kazimiera Maria
Published: December 2023

A partir de uma abordagem teórica fundamentada nos estudos da resiliência, este artigo apresenta uma análise comparativa da reconfiguração das relações laborais durante a crise financeira em Portugal, na Polónia e na Irlanda. É proposta uma conceptualização crítica de resiliência social, capaz de apreender tanto a organização do sistema que emerge no pós-crise como as relações dinâmicas de poder subjacentes, o sistema de regras e os arranjos institucionais e a redistribuição dos recursos. É argumentado que a crise financeira foi uma oportunidade para a convergência e liberalização dos modelos de mercado de trabalho na Europa.
Nos interstícios do subcampo: autoedição e empreendedorismo em músicos folk em Portugal no século XXI
Authors: Nunes Pedro Belchior
Published: December 2023

Este artigo aborda as práticas e valores de um conjunto de músicos em autoedição, dentro do universo peculiar da música popular de matriz rural em Portugal, no contexto das duas últimas décadas em que a produção de música sofre o impacto dos fenómenos de digitalização e desintermediação. Tomando como âncoras teóricas as teses de Bourdieu e de Becker sobre campos de produção cultural e mundos artísticos, respetivamente, bem como estudos recentes em torno das culturas musicais DIY (do-it-yourself), caracterizadas pela adesão a um conjunto de práticas e valores autónomos em relação aos circuitos dominantes de produção de música, e recorrendo a entrevistas semidirigidas a uma amostra de músicos, procuramos compreender o sentido das suas práticas em relação à edição e à sua articulação com outras atividades que desenvolvem para a disseminação da sua produção musical. Concluímos que a adesão a modos DIY de produção e distribuição de música nestes músicos, embora seja evidente em muitos casos, não é total ou incondicional, seja pelas ligações mais institucionais dentro de um subcampo de produção de música popular, seja pelas vantagens que muitos ainda encontram em estabelecer parcerias com editoras e distribuidoras.
Internal maxillary artery (IMax) – middle cerebral artery bypass in a patient with bilateral atherosclerotic carotid occlusion: A technical case report
Authors: Degollado-García Javier , Casas-Martínez Martin R. , Mejia Bill Roy Ferrufino , Balcázar-Padrón Juan C. , Rodríguez-Rubio Héctor A. , Nathal Edgar
Published: December 2023

Since the first description of the possible utilization of the internal maxillary artery for bypass surgery, there are some reports of its use in aneurysm cases; however, there is no information about the possible advantages of this type of bypass for cerebral ischemic disease.We present a 77-year-old man with a history of diabetes, hypertension, systemic atherosclerosis, and two acute myocardial infarctions with left hemiparesis. Imaging studies reported total occlusion of the right internal carotid artery and 75% occlusion on the left side, with an old opercular infarction and repeated transient ischemic attacks in the right middle cerebral artery territory despite medical treatment. After a consensus, we decided to perform a bypass from the internal maxillary artery to the M2 segment of the middle cerebral artery using a radial artery graft. After performing the proximal anastomosis, the calculated graft’s free flow was 216 ml/min. Subsequently, after completing the bypass, the patency was confirmed with fluorescein videoangiography and intraoperative Doppler. Postoperatively, imaging studies showed improvement in the perfusion values and the hemiparesis from 3/5 to 4+/5. The patient was discharged one week after the operation, with a modified Rankin scale of 1, without added deficits.The use of revascularization techniques in steno-occlusive disease indicates a select group of patients that may benefit from this procedure. In addition, internal maxillary artery bypass has provided a safe option for large areas of ischemia that cannot be supplied with a superficial temporal artery - middle cerebral artery bypass.
Phononic thermal conduction and thermal regulation in low-dimensional micro-nano scale systems: Nonequilibrium statistical physics problems from chip heat dissipation
Authors: Luo Tian-Lin , Ding Ya-Fei , Wei Bao-Jie , Du Jian-Ying , Shen Xiang-Ying , Zhu Gui-Mei , Li Bao-Wen ,   Department of Materials Science and Engineering, Southern University of Science and Technology, Shenzhen 518055, China,   School of Microelectronics, Southern University of Science and Technology, Shenzhen 518055, China,   Department of Physics, Southern University of Science and Technology, Shenzhen 518055, China,   International Quantum Academy, Shenzhen 518017, China
Published: December 2023

“Heat death”, namely, overheating, which will deteriorate the function of chips and eventually burn the device and has become an obstacle in the roadmap of the semiconductor industry. Therefore, heat dissipation becomes a key issue in further developing semiconductor. Heat conduction in chips encompasses the intricate dynamics of phonon conduction within one-dimensional, two-dimensional materials, as well as the intricate phonon transport through interfaces. In this paper, the research progress of the complexities of phonon transport on a nano and nanoscale in recent three years, especially the size dependent phonon thermal transport and the relationship between anomalous heat conduction and anomalous diffusion are summarized. Further discussed in this paper is the fundamental question within non-equilibrium statistical physics, particularly the necessary and sufficient condition for a given Hamiltonian whose macroscopic transport behavior obeys Fourier’s law. On the other hand, the methods of engineering the thermal conduction, encompassing nanophononic crystals, nanometamaterials, interfacial phenomena, and phonon condensation are also introduced. In order to comprehensively understand the phononic thermal conduction, a succinct overview of phonon heat transport phenomena, spanning from thermal quantization and the phonon Hall effect to the chiral phonons and their intricate interactions with other carriers is presented. Finally, the challenges and opportunities, and the potential application of phonons in quantum information are also discussed.
Suppression of stimulated Raman scattering kinetic bursts by intensity-modulated broadband laser
Authors: Liu Qing-Kang , Zhang Xu , Cai Hong-Bo , Zhang En-Hao , Gao Yan-Qi , Zhu Shao-Ping ,   Institute of Applied Physics and Computational Mathematics, Beijing 100094, China,   Graduate School of China Academy of Engineering Physics, Beijing 100088, China,   Beijing Computational Science Research Center, Beijing 100088, China,   Shanghai Institute of Laser Plasma, Shanghai 201899, China
Published: December 2023

Laser plasma instability is one of the difficulties that plague inertial confinement fusion. Broadband laser, as an effective tool for suppressing laser-plasma instabilities, has received a lot of attention in recent years. However, the nonlinear bursts of high-frequency instabilities, such as stimulated Raman scattering driven by broadband laser in the kinetic regime, make the suppression effect less than expected. In this study, a broadband laser model with intensity modulation is proposed. By choosing an appropriate intensity modulation envelope, it is possible to interrupt the amplification process of backscattered light in strong pulses, reduce the probability of high-intensity pulses inducing intense bursts, and drastically reduce the fraction of backscattered light and hot electron yield. Numerical simulations show that the intensity-modulated laser has a good ability to suppress stimulated Raman scattering. For a broadband laser with average power of \begin{document}$ 1.0 \times {10}^{15}\;{\mathrm{W}}/{\mathrm{c}}{{\mathrm{m}}}^{2} $\end{document} and a bandwidth of 0.6%, the reflectivity decreases by an order of magnitude and the fraction of hot electron energy above 20 keV decreases from 7.34% to 0.31% by using the intensity modulation technique. The above results confirm the feasibility of using the intensity-modulated broadband laser to suppress the high-frequency instability and are expected to provide a reference for designing the subsequent broadband laser-driven fusion experiments.
Septin 7 Interacts With Numb To Preserve Sarcomere Structural Organization And Muscle Contractile Function
Authors: De Gasperi Rita , Csernoch Laszlo , Dienes Beatrix , Gonczi Monika , Chakrabarty Jayanta K. , Goeta Shahar , Aslan Abdurrahman , Toro Carlos A. , Karasik David , Brown Lewis M. , Brotto Marco , Cardozo Christopher P.
Published: December 2023

Here, we investigated mechanisms by which aging-related reductions of the levels of Numb in skeletal muscle fibers contribute to loss of muscle strength and power, two critical features of sarcopenia. Numb is an adaptor protein best known for its critical roles in development including asymmetric cell division, cell-type specification and termination of intracellular signaling. Numb expression is reduced in old humans and mice. We previously showed that, in mouse skeletal muscle fibers, Numb is localized to sarcomeres where it is concentrated near triads; conditional inactivation of Numb and a closely related protein Numb-like (NumbL) in mouse myofibers caused weakness, disorganization of sarcomeres and smaller mitochondria with impaired function. Here, we found that a single knockout of Numb in myofibers causes reduction in tetanic force comparable to a double Numb, NumbL knockout. We found by proteomics analysis of protein complexes isolated from C2C12 myotubes by immunoprecipitation using antibodies against Numb, that Septin 7 is a potential Numb binding partner. Septin 7 is a member of the family of GTP-binding proteins that organize into filaments, sheets and rings, and is considered part of the cytoskeleton. Immunofluorescence evaluation revealed a partial overlap of staining for Numb and Septin 7 in myofibers. Conditional, inducible knockouts of Numb led to disorganization of Septin 7 staining in myofibers. These findings indicate that Septin 7 is a Numb binding partner and suggest that interactions between Numb and Septin 7 are critical for structural organization of the sarcomere and muscle contractile function.
Heterogeneous presynaptic receptive fields contribute to directional tuning in starburst amacrine cells
Authors: Gaynes John A. , Budoff Samuel A. , Grybko Michael J. , Poleg-Polsky Alon
Published: December 2023

The processing of visual information by retinal starburst amacrine cells (SACs) involves transforming excitatory input from bipolar cells (BCs) into directional calcium output. While previous studies have suggested that an asymmetry in the kinetic properties of bipolar cells along the soma-dendritic axes of the postsynaptic cell could enhance directional tuning at the level of individual branches, it remains unclear whether biologically relevant presynaptic kinetics contribute to direction selectivity when visual stimulation engages the entire dendritic tree. To address this question, we built multicompartmental models of the bipolar–SAC circuit and trained them to boost directional tuning. We report that despite significant dendritic crosstalk and dissimilar directional preferences along the dendrites that occur during whole-cell stimulation, the rules that guide BC kinetics leading to optimal directional selectivity are similar to the single-dendrite condition. To correlate model predictions to empirical findings, we utilized two-photon glutamate imaging to study the dynamics of bipolar release onto ON- and OFF- starburst dendrites in the murine retina. We reveal diverse presynaptic dynamics in response to motion in both BC populations; algorithms trained on the experimental data suggested that the differences in the temporal release kinetics are likely to correspond to heterogeneous receptive field (RF) properties among the different BC types, including the spatial extent of the center and surround components. In addition, we demonstrate that circuit architecture composed of presynaptic units with experimentally recorded dynamics could enhance directional drive but not to levels that replicate empirical findings, suggesting other DS mechanisms are required to explain SAC function. Our study provides new insights into the complex mechanisms underlying direction selectivity in retinal processing and highlights the potential contribution of presynaptic kinetics to the computation of visual information by starburst amacrine cells.
The zinc-finger transcription factor Sfp1 imprints specific classes of mRNAs and links their synthesis to cytoplasmic decay
Authors: Kelbert Moran , Jordán-Pla Antonio , de Miguel-Jiménez Lola , García-Martínez José , Selitrennik Michael , Guterman Adi , Henig Noa , Granneman Sander , Pérez-Ortín José E , Chávez Sebastián , Choder Mordechai
Published: December 2023

To function effectively as an integrated system, the transcriptional and post-transcriptional machineries must communicate through mechanisms that are still poorly understood. Here, we focus on the zinc-finger Sfp1, known to regulate transcription of proliferation-related genes. We show that Sfp1 can regulate transcription either by binding to promoters, like most known transcription activators, or by binding to the transcribed regions (gene bodies), probably via RNA polymerase II (Pol II). We further studied the first mode of Sfp1 activity and found that, following promoter binding, Sfp1 binds to gene bodies and affects Pol II configuration, manifested by dissociation or conformational change of its Rpb4 subunit and increased backtracking. Surprisingly, Sfp1 binds to a subset of mRNAs co-transcriptionally and stabilizes them. The interaction between Sfp1 and its client mRNAs is controlled by their respective promoters and coincides with Sfp1’s dissociation from chromatin. Intriguingly, Sfp1 dissociation from the chromatin correlates with the extent of the backtracked Pol II. We propose that, following promoter recruitment, Sfp1 accompanies Pol II and regulates backtracking. The backtracked Pol II is more compatible with Sfp1’s relocation to the nascent transcripts, whereupon Sfp1 accompanies these mRNAs to the cytoplasm and regulates their stability. Thus, Sfp1’s co-transcriptional binding imprints the mRNA fate, serving as a paradigm for the cross-talk between the synthesis and decay of specific mRNAs, and a paradigm for the dual-role of some zinc-finger proteins. The interplay between Sfp1’s two modes of transcription regulation remains to be examined.
Alternative end-joining results in smaller deletions in heterochromatin relative to euchromatin
Authors: Miller Jacob M. , Prange Sydney , Ji Huanding , Rau Alesandra R. , Khodaverdian Varandt Y. , Li Xiao , Patel Avi , Butova Nadejda , Lutter Avery , Chung Helen , Merigliano Chiara , Rawal Chetan C. , Hanscom Terrence , McVey Mitch , Chiolo Irene
Published: December 2023

Pericentromeric heterochromatin is highly enriched for repetitive sequences prone to aberrant recombination. Previous studies showed that homologous recombination (HR) repair is uniquely regulated in this domain to enable ‘safe’ repair while preventing aberrant recombination. In
Drosophila
cells, DNA double-strand breaks (DSBs) relocalize to the nuclear periphery through nuclear actin-driven directed motions before recruiting the strand invasion protein Rad51 and completing HR repair. End-joining (EJ) repair also occurs with high frequency in heterochromatin of fly tissues, but how alternative EJ (alt-EJ) pathways operate in heterochromatin remains largely uncharacterized. Here, we induce DSBs in single euchromatic and heterochromatic sites using a new system that combines the DR-
white
reporter and I-SceI expression in spermatogonia of flies. Using this approach, we detect higher frequency of HR repair in heterochromatin, relative to euchromatin. Further, sequencing of mutagenic repair junctions reveals the preferential use of different EJ pathways across distinct euchromatic and heterochromatic sites. Interestingly, synthesis-dependent microhomology-mediated end joining (SD-MMEJ) appears differentially regulated in the two domains, with a preferential use of motifs close to the cut site in heterochromatin relative to euchromatin, resulting in smaller deletions. Together, these studies establish a new approach to study repair outcomes in fly tissues, and support the conclusion that heterochromatin uses more HR and less mutagenic EJ repair relative to euchromatin.
The intricate relationship of G-Quadruplexes and bacterial pathogenicity islands
Authors: Lyu Bo , Song Qisheng
Published: December 2023

The dynamic interplay between guanine-quadruplex (G4) structures and pathogenicity islands (PAIs) represents a captivating area of research with implications for understanding the molecular mechanisms underlying pathogenicity. This study conducted a comprehensive analysis of a large-scale dataset from reported 89 pathogenic strains of bacteria to investigate the potential interactions between G4 structures and PAIs. G4 structures exhibited an uneven and non-random distribution within the PAIs and were consistently conserved within the same pathogenic strains. Additionally, this investigation identified positive correlations between the number and frequency of G4 structures and the GC content across different genomic features, including the genome, promoters, genes, tRNA, and rRNA regions, indicating a potential relationship between G4 structures and the GC-associated regions of the genome. The observed differences in GC content between PAIs and the core genome further highlight the unique nature of PAIs and underlying factors, such as DNA topology. High-confidence G4 structures within regulatory regions of Escherichia coli were identified, modulating the efficiency or specificity of DNA integration events within PAIs. Collectively, these findings pave the way for future research to unravel the intricate molecular mechanisms and functional implications of G4-PAI interactions, thereby advancing our understanding of bacterial pathogenicity and the role of G4 structures in pathogenic diseases.
Book review of: Silver, N. (2017). Finance, Society and Sustainability: How to Make the Financial System Work for the Economy, People and Planet.
Authors: Biryomumeisho Justus
Published: December 2023

Book review of: Silver, N. (2017). Finance, Society and Sustainability: How to Make the Financial System Work for the Economy, People and Planet.
Genetic algorithm-based re-optimization of the Schrock catalyst for dinitrogen fixation
Authors: Strandgaard Magnus , Seumer Julius , Benediktsson Bardi , Bhowmik Arghya , Vegge Tejs , Jensen Jan H.
Published: December 2023

This study leverages a graph-based genetic algorithm (GB-GA) for the design of efficient nitrogen-fixing catalysts as alternatives to the Schrock catalyst, with the aim to improve the energetics of key reaction steps. Despite the abundance of nitrogen in the atmosphere, it remains largely inaccessible due to its inert nature. The Schrock catalyst, a molybdenum-based complex, offered a breakthrough but its practical application is limited due to low turnover numbers and energetic bottlenecks. The genetic algorithm in our study explores the chemical space for viable modifications of the Schrock catalyst, evaluating each modified catalyst’s fitness based on reaction energies of key catalytic steps and synthetic accessibility. Through a series of selection and optimization processes, we obtained fully converged catalytic cycles for 20 molecules at the B3LYP level of theory. From these results, we identified three promising molecules, each demonstrating unique advantages in different aspects of the catalytic cycle. This study offers valuable insights into the potential of generative models for catalyst design. Our results can help guide future work on catalyst discovery for the challenging nitrogen fixation process.
Satisfaction of cooperatives: analysis of measurement scales
Authors: De Oliveira Hudson do Vale , Tezza Rafael , Cancellier Éverton Luís Pellizzaro de Lorenzi , Andion Carolina
Published: December 2023

Satisfaction is a complex and important construct in different areas of knowledge, such as marketing and consumer behavior. Based on the importance of this construct, the objective of this article is to identify and analyze measurement scales referring to the perception of "cooperative satisfaction" in relation to cooperatives. This is an exploratory study with a qualitative and descriptive character, with systematic review as a method of investigation. It has been identified that there is no specific scale in the literature aimed at measuring the "satisfaction of the co-workers" construct. In any case, it was found that the scales that exist for the construct "satisfaction" can be used to measure the satisfaction of the cooperates, a construct considered in this article, with the appropriate adaptations, as can already be observed in other areas in which scales for the construct "satisfaction" are used.
AUTISMO E EDUCAÇÃO NAS PÁGINAS DOS JORNAIS FOLHA DE SÃO PAULO E JORNAL DO BRASIL NOS ANOS 1980
Authors: Lopes Bruna Alves
Published: December 2023

Este artigo tem por objetivo analisar matérias publicadas na década 1980 no Jornal do Brasil e na Folha de São Paulo enfatizando nas notícias que articulam autismo e educação. Trata-se de uma pesquisa documental com abordagem histórica que considerou os apontamentos de Luca (2005) ─ que compreende os periódicos enquanto fontes pertinentes para a construção de narrativas históricas ─ e Pontes e Silva (2012) que compreendem que os periódicos retratam e constroem a realidade em suas páginas. Observarmos que, junto com as medidas de atendimento educacional voltado para os autistas, as associações desenvolveram um importante trabalho de divulgação da temática no Brasil demonstrando a relevância do ativismo familiar que deixou como herança a abertura do debate sobre a importância do direito dos autistas ao acesso à educação.
Response of Okra Varieties to Different Fertilizer Level of Humic Acid
Authors: Aluko Matthew , Alabi Bolaji Toyin
Published: December 2023

Background and Objective: Poor soil fertility is a great limitation to crop production. The adverse effects of chemical fertilizer and the unavailability of organic fertilizer in large quantities are another challenge. The research was conducted at the Research Farm of Ekiti State University, Ado-Ekiti, Nigeria to examine the effects of appropriate doses of humic acid (HA) fertilizers for maximum performance of okra.

Materials and Methods: The experiment was laid out in Randomized Complete Block Design (RCBD) with three replicates. The two factorial experiments comprise four levels of humic acid fertilizer (0, 5.0, 10.0, and 15.0 g HA plant-1) and NPK 15-15-15 (150 kg hac-1), and two okra varieties. The two okra varieties were allocated to main plots while the fertilizer levels were allocated to sub-plots. The collected data on final plant height (cm), the number of leaves per plant, the number of fruits per plant, the weight of fresh fruit per plant (g), the fruit length (cm), the leaf area (cm3), the fruit diameter (cm), and the stem diameter (cm) and analyzed with the IRRI STAR Software.

Results: The result showed that the traits measured were significantly different for (HA) levels and NPK fertilizers. The varieties were significantly different for the measured traits except for leaf area, fruit diameter, and fruit length while the varieties x amendment levels were significant for plant height, leaf area, fruit diameter, and stem diameter while others are not significant. The measured traits increases as the humic acid levels increase. It was observed that the plants that received 15.0 g HA plant-1 performed better, followed by 10.0g HA plant-1 and NPK 15-15-15 respectively. However, the differences in the plants that received 5.0g HA plant-1 and 7.5g HA plant-1 were minute.

Conclusion: It is therefore concluded that 5.0g HA plant-1 should be applied for optimal okra yield.
The Role of Agroforestry Systems in Enhancing Climate Resilience and Sustainability- A Review
Authors: Pancholi Roshan , Yadav Ravi , Gupta Hitesh , Vasure Narendra , Choudhary Shishpal , Singh Moirangthem Nobinchandra , Rastogi Mausmi
Published: December 2023

Agroforestry, as the synergistic integration of woody perennials with crops and livestock systems, is posited along with a multi-functional land-use strategy with substantial implications for climate adaptation and mitigation. The article embarks on an analytical journey through historical paradigms, typologies such as silvo-pastoral and agro-silvicultural systems, and evaluates their contributions to enhancing soil health, water management, carbon sequestration, biodiversity, and microclimate regulation. Distinctive case studies spanning diverse geographic regions including Africa, Southeast Asia, Europe and South America are scrutinized to elucidate how agroforestry initiatives can be contextually optimized for addressing region-specific environmental challenges and socio-economic needs. Sustainability aspects are dissected into economic, social, and environmental benefits, thereby constructing a holistic view of the multi-dimensional advantages of agroforestry systems. The review identifies significant research lacunae, anticipates technological innovations such as remote sensing and machine learning algorithms for data-driven management, and delineates strategies for scaling up best practices. Additionally, the article explores the impediments to widespread adoption, which encompass land tenure complications, economic viability, socio-cultural factors, and policy and regulatory constraints. In the review accentuates the need for an integrated, multi-disciplinary approach involving concerted efforts from researchers, policymakers, and stakeholders for the actualization of agroforestry's full potential in achieving global sustainability and climate resilience objectives.
Determinants of Adoption of Climate Smart Agricultural Technologies among Farm Households in Southern Karnataka, India
Authors: H. M. Nandini , Venkataramana M. N. , K. Anil , Thimmegowda M. N.
Published: December 2023

The Climate change and its effects on agriculture pose major concerns for achieving a food-secure economy, particularly in developing countries like India. Furthermore, the carbon footprints resulting from agricultural activities are also a significant concern for the future climate. This study made an attempt to analyse the factors influencing the adoption of climate smart agricultural technologies among farmers in Chikkaballapur and Tumakuru, districts of Southern Karnataka using primary data collected from 180 randomly selected farm-households comprising 45 adopters and 45 non-adopters of climate smart agricultural technologies from each district. The data was analysed by fitting probit model to assess the factors influencing the adoption of climate smart agricultural technologies. The empirical results revealed that education (0.51), land holdings (0.63), credit accessibility (3.83), membership in organization (2.47), access to weather information (4.10), attended training (2.00) and farm income (0.49) were positive and significant relationship with the adoption of climate smart agricultural technologies in Chikkaballapur district. Similarly, in Tumakuru district age (0.14), contact with extension agent (2.78), credit accessibility (2.01), membership in organization (2.75), access to weather related information (2.16), participation in training (2.93) and farm income (0.34) was positive and significantly influenced the adoption of climate smart agricultural technologies among farm households. Whereas, age (-0.14) and land holdings (-0.39) of the respondents were negatively influenced the adoption in Chikkaballapur and Tumakuru districts, respectively. The findings, suggests that  more emphasis should be given to increase awareness on innovative technologies and most importantly the institutional factors place a crucial role in enhancing the adoption of climate smart agricultural technologies in the study area among the farming community.
Advancement in Tissue Culture Techniques for Fruit Crops
Authors: Jain Shubham , Sharma Rajat , Nidhi Nivedita , Behera Swosti Debapriya , Baksh Hari , Sharma Rohit , Mishra Satyam , Kumar Vikas , Anushi
Published: December 2023

Tissue culture is a highly promising approach that enables the efficient propagation of many plants from tiny fragments of the parent plant within a relatively brief timeframe and confined area. Tissue culture, a contemporary approach, is primarily employed for the efficient and extensive replication of many commercially significant plant species, such as the date palm. Utilizing the tissue culture technique presents a potential approach for generating a substantial quantity of genetically homogeneous palm plants that resemble other plants and yield typical fruit within four years from initial planting. Furthermore, this technique allows to produce date palm plants devoid of diseases, exhibiting an exceptionally high survival rate of nearly 100% when compared to the traditional vegetative propagation of shoots, owing to the robustness of their root system. The process of surface sterilization holds significant importance in the production of explants for in vitro studies, as it effectively addresses the issue of bacterial and fungal contamination originating from field sources, which might vary considerably across different fruit plant species. The efficacy of tissue culture techniques for date palm acclimatization in vitro is contingent upon the observation of leaf count prior to transplantation in the greenhouse. Hence, the primary objective of this study was to investigate the determinants that govern the tissue culture of fruit trees. India is known for being the native land of various fruit crops that are both significant and minor in terms of their importance. These crops include Indian gooseberry (Emblica officinalis Gaertn.), Karonda (Carissa carandas L.), Bael (Aegle marmelos Corr.), Jamun (Syzygium cuminii L.), and jackfruit (Artocarpus heterophyllus L.), etc. These fruits possess considerable nutritional, medicinal, and therapeutic value, making them highly valuable in commercial sectors such as medicine, food, and cosmetics. The limited availability of suitable planting materials imposes constraints on the commercial production process for these crops. Using plant tissue culture techniques holds promise in substantially augmenting the number of novel cultivars or genotypes inside fruit crops. The primary aim of this review study is to consolidate and synthesize the extant body of knowledge about the tissue culture techniques employed in cultivating various fruit crops.
Effect of Integrated Nutrient Management on Growth, Yield and Quality in Garlic (Allium sativum L.)
Authors: Singh Bhag , Sharma Hem Raj , Impa H. R.
Published: December 2023

Garlic has the charisma of a potent remedy and has held its repute as a therapeutic panacea since the dawn of civilization. So to increase its productivity and medicinal value integrated approach will be required. Allicin is the main bioactive compound, which is responsible for the medicinal value produced by garlic. It is present in the bulb in the form of allicin, which is converted to allicin when the bulb is cut or crushed. The study was conducted on the garlic variety “Kandaghat Selection”. The experiment was laid out in Randomized Complete Block Design (RCBD) with three replications comprising fourteen treatments was carried out at the Experimental farm of Horticulture Research and Training Station and KVK, Kandaghat, Dr. YS Parmar University of Horticulture and Forestry, Nauni, Solan (HP) during the Rabi season of 2018-19. Out of the fourteen treatments comprising of 100% recommended dose of NPK + 50 kg S/ha + 5% Jv @ 1 L/ m2 (T7) recorded significantly higher plant height, number of leaves per plant, bulb weight, bulb diameter, number of cloves per bulb, bulb yield, dry matter content of bulb and TSS. Phytomedical evaluation by HPLC showed that all bulbs from all treatments are rich in allicin content and their recorded values were higher than pharmaceutical grade.
Reimbursement to Pharmacies for Generic Drugs by Medicare Part D Sponsors
Authors: Hernandez Inmaculada , Gabriel Nico , Kaltenboeck Anna , Boccuti Cristina , Hansen Ryan N. , Sullivan Sean D.
Published: December 2023

This study evaluates whether organizations that offer Medicare Part D plans (referred to as Part D sponsors) overpay pharmacies for generic drugs.