bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors influencing the spread of local anesthetic during the transverse abdominal plane block (study on unfixed corpses)
Authors: Bespalov E. K. , Novikov D. I. , Zaitsev A. Yu. , Svetlov V. A. , Evstropova A. A.
Published: December 2023

Introduction. Despite the proven clinical effectiveness of the transverse abdominal plane block (TAP block), the factors affecting the distribution of local anesthetic in the fascial case have not been fully studied, and there are no clear recommendations regarding the choice of the volume of local anesthetic taking into account anthropometry.

The objective was to identify anthropometric factors influencing the choice of an adequate volume of local anesthetic for performing a TAP block.

Materials and methods. In the pathology department, 40 upper and 40 lateral TAP blocks were performed in 20 corpses using ultrasound navigation. On the right side, 20 ml (block group A) of diamond green dye solution was injected, on the left side - 30 ml (block group B). The dependence of the area of distribution of the dye solution on the volume of the body, weight and height of the corpse was investigated. The analysis of the effect of damage in the execution zone on the area of dye distribution was carried out.

Results. In the group B, the dye in 100 % of cases (n=18) spread to the nerve passage areas Th6 – Th9 in the upper TAP block and Th9 – L1 in the lateral TAP block. In group A, in 38.8 % of cases (n=7), the dye did not spread to the Th8-Th9 nerve passage area with the upper TAP block, as well as to the Th10 and Th12–L1 passage areas with the lateral TAP block. An inverse correlation of the growth and the dye distribution area was revealed (p < 0.01). In all unfixed corpses whose height exceeded 179 cm, the dye could not compromise all the zones of passage of nerve structures. Tissue damage in the area of the block limited the spread of the dye.

Conclusion. Adequate distribution of local anesthetic depends on the patient’s height. With the height of >179 cm, 20 ml may not be enough to perform a TAP block, and <177 cm – 30 ml may be excessive.
Clinical case of lightning injury
Authors: Kazarinov D. N. , Kirov M. Yu.
Published: December 2023

Atmospheric electricity damage as a result of lightning strike is a relatively rare condition in intensive care medicine, however it can be accompanied by high mortality and serious complications in the majority of survived patients.

The objective was to demonstrate a clinical case of lightning injury and discussion of diagnostic and treatment aspects in this condition.

Materials and Methods. 18-yr old patient was delivered to hospital after lightning strike. She lost consciousness, there was no breathing for a short time, and the witnesses provided artificial respiration and external cardiac compressions. On admission, the signs of shock were present in parallel with dopamine infusion, the skin was pale-grey and cold, with traces of thermal damage according to the type of contact with metal of various localization on the neck, scalp, front surface of the chest and abdominal wall, in the groin, on the left foot. The patient was hospitalized to ICU, therapeutic and diagnostic measures were started. We revealed decompensated lactic acidosis, biochemical signs of myocardial and muscle damage. The infusion therapy, analgesics, antibiotics, proton pump inhibitors, anticoagulants were administered. During the therapy in the first 6 hours, the signs of shock were attenuated, in 4 days, the patient was transferred to traumatological department in a stable state. After the transfer from the ICU, hearing decline as well as pain and sensory disturbances in the left foot are persisting.

Conclusion. An integrated approach is required in the diagnosis, treatment, and rehabilitation of patients with lightning injury.
Supraneural transforaminal epidural injection in the treatment of radiculopathy in the lumbar spine – a brief descriptive overview and technique of manipulation
Authors: Averyanov D. A. , Khrapov K. N.
Published: December 2023

Fluoroscopy guided epidural injection is often used to treat radicular pain in the lumbar spine. Risk and effectiveness data vary depending on injection routes and underlying pathology. There are several options for accessing the epidural space in the lumbosacral spine to perform an analgesic injection – caudal, interlaminar and transforaminal. Transforaminal epidural injection is currently the most studied and widespread in the foreign practice of treating chronic pain. A brief overview describes transforaminal accesses to the epidural space of the lumbar spine and needles used for this purpose, lists possible adverse events and complications, and also provides a detailed illustrated description of supraneural transforaminal access.
A digital solution for determining the severity of paroxysmal sympathetic hyperactivity syndrome in patients with brain injury
Authors: Tsentsiper L. M. , Motienko A. I. , Terekhov I. S. , Levonevskiy D. K. , Samochernykh K. A. , Kondratyev A. N.
Published: December 2023

Paroxysmal sympathetic hyperactivity syndrome is a frequent complication of acute severe brain injury, so with severe traumatic brain injury, it develops in 30 % of patients. Despite a large number of publications, the issues of diagnosis, prevention and treatment of this syndrome remain unresolved. To date, the assessment of the syndrome of paroxysmal sympathetic hyperactivity takes, with proper training of the doctor, from 8 to 15 minutes, taking into account the calculation of points using a calculator. With the digitalization of this process, a single assessment will take about 2–3 minutes to enter the indicators. In this case, the calculation will occur automatically. Subsequently, when using «wearable gadgets for measurement», the process of filling in indicators can also occur automatically. The application allows to register and store basic data about users who can have three roles: patients, specialist doctors, administrators. The creation of a database of patients with sympathetic hyperactivity syndrome will significantly improve diagnostic methods and assess the adequacy of therapy. Medical data is only useful if it can be turned into meaningful information. This requires high-quality data sets, uninterrupted communication between IT systems, and standard data formats that can be processed by humans and machines.
Efficacy and safety of ibuprofen in postoperative pain management among children; systematic review
Authors: Almuntashiri Mohammed , Alshamrani Hamed , Alqurashi Abdulaziz , Alharthy Khaled , Almotairi Abdulmjeed , Otibi Yasir
Published: December 2023

Postoperative pain management is a critical aspect of care in pediatric patients undergoing surgical procedures. Ibuprofen has been examined as a treatment for mild to moderate pain in the postoperative management of children. This systematic review aimed to evaluate the efficacy and safety of ibuprofen in managing postoperative pain among children. A literature review was conducted using PubMed from 2013 to 2023. Keywords \"ibuprofen,\" \"efficacy,\" \"safety,\" and \"postoperative\" were used for the research process. All relevant articles evaluating the efficacy and safety of ibuprofen in managing postoperative pain among children (under 18 years old) were included. The search identified 42 papers through PubMed databases. Only five studies met the objective of the systematic review. The included studies were a pooled analysis study (n=534), a prospective, double-blind, randomized clinical trial (n=30), a retrospective study (n=1065), and a multicenter, randomized, double-blind, placebo-controlled trial (n=161). Moreover, the total number of patients was 1,850, aged 1 to 19 years. Ibuprofen (oral or intravenous) and acetaminophen were the interventions examined in the included studies. The findings from the included studies suggested that ibuprofen is an effective analgesic option for children undergoing various surgical procedures. The reviewed studies consistently reported a favorable safety profile for ibuprofen in pediatric patients, with minimal incidence of adverse events. Further research with more studies is needed to expand the understanding of optimal pain management strategies in pediatric surgery and explore the comparative effectiveness of different analgesic interventions.
Nail-patella syndrome-Case image
Authors: Barsoum Zakaria
Published: December 2023

Nail-patella syndrome is a rare disorder with \'\' iliac horns\'\' its pathognomonic sign in X-ray pelvis. May I submit this case image for educational purposes of all colleagues and trainees?
MIOLOGIA COMPARADA DO MEMBRO PÉLVICO DE MACACO-PREGO E MACACO-DA-NOITE
Authors: De Lima Ana Rita , Santo Iara Fernanda Lima do Espírito , Gonçalves José Gabriel Ribeiro , Gonçalves Thamara Cozzi , Imbeloni Aline Amaral , Branco Érika
Published: December 2023

O estudo da miologia nos mamíferos é uma tarefa de extrema importância, pois pode gerar informações sobre o comportamento destes animais. Aotus azarai infulatus e Sapajus apella pertencem à mesma família, contudo de subfamílias distintas, sendo assim objetivo deste trabalho consistiu em descrever a musculatura do membro pélvico comparando as duas espécies. Foram estudados 3 espécimes de A. azarai infulatus e 3 de S. apella. Os animais foram fixados em solução aquosa de formaldeído a 10% e dissecados para a evidenciação dos músculos. Após este procedimento, foram analisados os músculos que compõem a coxa e a perna de ambas as espécies, sendo a coxa composta pelos seguintes músculos: tensor da fáscia lata, vasto lateral, quadrado femoral, adutor, bíceps femoral, semitendinoso, abdutor crural caudal (presente apenas no S. apella), reto femoral, vasto medial, sartório, semimembranoso, pectíneo e grácil. Em relação a perna, os músculos identificados foram: gastrocnêmio (cabeças lateral e medial), extensor digital lateral, fibular longo, extensor digital longo, tibial cranial, flexor digital superficial (presente apenas no S. apella), poplíteo e extensor longo do hálux. A organização dos músculos no S. apella e no A. azarai infulatus é similar ao de alguns primatas como o babuíno e o chimpanzé assim como o homem, no entanto essas espécies também apresentaram similaridades com mamíferos domésticos e animais selvagens, diferindo destes casos devido à presença do músculo extensor longo do hálux, exclusivo de primatas por conta da presença do polegar opositor.
Two Aerodynamic Mid-Fidelity Approaches on a Distributed Propulsion Wing
Authors: Herzog Nikolai , Keller Dennis , Breitsamter Christian
Published: December 2023

A comparison of two potential-theory based mid-fidelity approaches on the aerodynamics of a distributed propeller–wing tractor configuration is presented. The design space for aircraft configurations is enlarged by using distributed electric propulsion so a demand for investigating different variants, especially regarding the number of propellers, is present. While many lower fidelity tools are available in the literature, they are often only documented with integral results. This paper presents two different, independently implemented numerical approaches and provides a comparison of spanwise load distributions on a distributed propeller configuration under cruise conditions with existing Reynolds-averaged Navier–Stokes (RANS) results. The isolated propeller and wing calculations using both methods are verified a priori with respect to their agreement. In addition, a discretization study of both methods is presented. The detailed results of the spanwise lift and drag distributions are compared between the two methods. Two different angles of attack and two different propeller pitch settings are calculated, and the differences in the spanwise distributions and the governing integral results between both methods and the RANS results are highlighted. Finally, a comparison of the individually required computational effort is presented.
Eradicating Boko Haram Insurgency in Nigeria through the Complementarity of the ICC
Authors: Anya Sylvester , Nwatu Samuel , Olorunfemi John
Published: December 2023

Kidnapping, hostage taking, armed robbery, and bomb and gun attacks, among other terrorist activities perpetrated in the Boko Haram insurgency, especially in the Northeastern part of Nigeria, have led to wanton loss and destruction of life and property, violations of fundamental rights, socio-economic dislocation, and fear of insecurity generally. War crimes and crimes against humanity have allegedly been committed in the insurgency. The study aims to ascertain the best approach for the International Criminal Court (ICC) to exercise complementary jurisdiction towards eradicating the Boko Haram insurgency in Nigeria. While revealing the limitations of the Nigerian domestic system and pointing out the procedural and substantive flaws of the ICC in the fulfilment of its mandate, the paper recommends proactive complementarity in effectively tackling the insurgency. It concludes by advocating for domestication, better cooperation, and collaborative strategies with the international community to eradicate the Boko Haram insurgency in Nigeria.
TRANSTORNOS MENTAIS NO CONTEXTO DOS CENTROS DE ATENÇÃO PSICOSSOCIAL (CAPS): UMA ANÁLISE EPIDEMIOLÓGICA - REVISÃO INTEGRATIVA
Authors: Freitas Gabriel Nogueira de , Carneiro Stânia Nágila Vasconcelos
Published: December 2023

Este artigo apresenta uma revisão contextual, complementar e conceitual sobre os transtornos mentais nos Centros de Atenção Psicossocial (CAPS), no Brasil, e o perfil epidemiológico dos pacientes atendidos. A pesquisa destaca a complexidade dessas condições e a necessidade de uma abordagem integral que leve em consideração os fatores biopsicossociais que as influenciam. A análise ressalta que os transtornos mentais são fenômenos multifacetados que afetam a funcionalidade e o bem-estar dos indivíduos. A presença de Transtornos Mentais Comuns (TMC) na população é destacada, evidenciando a importância de uma compreensão mais ampla dessas condições. No contexto dos serviços de saúde mental, é fundamental alinhar as práticas com os princípios do Sistema Único de Saúde (SUS), garantindo uma abordagem em rede que considere os determinantes sociais da saúde. A expansão da capacidade dos serviços de saúde mental, com a integração eficaz dos CAPS e dos Ambulatórios de Saúde Mental, é recomendada para assegurar o tratamento adequado para diferentes níveis de gravidade. O estudo também destaca disparidades de gênero nas prevalências e características dos transtornos mentais, enfatizando a necessidade de abordagens sensíveis ao gênero na prestação de serviços. Além disso, políticas públicas devem abordar os determinantes sociais da saúde mental, como desigualdades socioeconômicas, apoio familiar e conexões sociais. Por fim, a pesquisa incentiva o desenvolvimento de mais estudos epidemiológicos para uma compreensão mais profunda da prevalência dos Transtornos Mentais Comuns (TMC), visando melhorar as intervenções terapêuticas e focos de atendimento.
Generation of a plot component for a tabletop role-playing game
Authors: Ключиков Аркадий Викторович , Челышева Диана Антоновна
Published: December 2023

Проведён анализ предметной области и актуальности настольных ролевых
игр, а также их влияние на сферы деятельности человека. Изучена механика
игрового процесса настольной ролевой игры Подземелья и драконы.
Рассмотрены программные решения для создания сюжетного описания локаций,
в том числе графическое представление карт и одностраничные приключения.
Реализованы дизайн и адаптивный пользовательский интерфейс. Сформирована
архитектура базы данных, а также реализована в формате JSON-файлов.
Разработана архитектура модели, а также произведена её настройка. Описан
блочный способ построения сюжета. Разработан алгоритм работы приложения
по генерации сюжетной составляющей. Сформированы списки сюжетных
составляющих, а также реализована логика случайного выбора участков
описания с проверкой на адекватность и сочетаемость описания.
Environmental problems of the Russian Arctic single-industry towns in the population estimates
Authors:   Petrozavodsk State University, Pitukhina M.A. , Belykh A.D. ,   Institute of Economics of the Karelian Research Centre of the Russian Academy of Sciences
Published: December 2023

The article considers the environmental problems of single-industry towns in the Russian Arctic via population assessments. When assessing environmental problems, a whole range of studies is applied — a sociological survey of respondents living in the single-industry towns of Kirovsk and Kostomuksha, economic statistics and desk research. Desk research makes it possible to draw conclusions about environmental complaints of mono-town residents and the environmental responsibility of the largest enterprises in the Arctic. The results of the study show that situation in Arctic regions with waste sorting and recycling is very acute. Almost all Arctic regions are among the outsiders. In conclusion, the authors formulate recommendations to improve environmental policy pursued in the Arctic mono-towns taking into account the population opinion. The proposed recommendations include the development of a migration model for the Arctic mono-towns, implementation of measures for the disposal and recycling of municipal solid waste, strengthening public environmental control, economic incentives for the use of clean technologies, development of ecological tourism, etc.
Revitalisasi Peran Perangkat Kewilayahan Melalui Pelimpahan Sebagian Kewenangan Bupati Fakfak Kepada Kepala Distrik Fakfak
Authors: Sanaki Abdul Anwar , Djohan Djohermansyah , Lukman Sampara
Published: December 2023

The authority given to several fields overlaps, for example authority has been given in accordance with Regent Regulation Number 33 of 2012 concerning the Delegation of Part of the Regent's Authority to District Heads in the Fakfak Regency Government Environment, but in practice this is not the case, the agencies at the Regency level are in charge of the field/sector In fact, they almost never coordinate with the District, so that the functions of the District according to Regent Regulation Number 33 of 2012 are not carried out properly. This research uses a qualitative method with a descriptive approach using theory from Iglesias (Kaho, 1997: 59) with primary and secondary data sources. Data collection techniques were carried out using interviews, observation and documentation, data analysis techniques used were data reduction and drawing conclusions. Based on the research results, it was concluded that the ideal revitalization of the role of regional apparatus through delegating the authority of the Regent of Fakfak to the Head of the Fakfak District must be followed by increasing financial capacity, apparatus capability, community participation and non-human resource capabilities. The implementation of the role of regional apparatus through the delegation of part of the authority of the Regent of Fakfak to the Head of the Fakfak District has not been optimal, where the delegation of authority for the fields of government, economic development, education and health and civil service has not been fully followed by giving full authority to the Head of the District, or it seems still half-hearted because The district head's space for movement is always monitored by the regent regarding the implementation of his authority. The process of delegating authority is still not able to run optimally because the district's resources are still limited so that service activities are not yet optimally felt by the community.
FINITE APPROXIMATIONS OF THE PROBLEM OF OPTIMAL IMPULSE STABILIZATION FOR A SYSTEM WITH AFTEREFFECT
Authors: DOLGII YU. , A. SESEKIN A. SESEKIN
Published: December 2023

A method for constructing finite-dimensional approximations for the optimal impulse stabilizing control of a linear autonomous system of differential equations with aftereffect is proposed. Auxiliary finite-dimensional problems of optimal stabilization of linear autonomous systems of ordinary differential equations with non-impulse controls are used. A procedure for reducing the dimension of a system of algebraic matrix Riccati equations is described.
The Use of Orem’s Theory of Self-Care Deficiency in the Patient with Delirium: A Case Study
Authors:   Selcuk University, Faculty of Nursing, Konya, Turkey, Aydin Zekiye , Lok Neslihan ,   Selcuk University, Faculty of Nursing, Konya, Turkey
Published: December 2023

Delirium is a common and costly problem in intensive care unit patients. For this reason, it is very important for the nurses who care for the patient who develops delirium to recognize, evaluate and plan the care of delirium. This case; The patient who applied to the emergency room with the complaint of shortness of breath and was taken to the intensive care unit and developed delirium; It is planned to provide care according to Orems “Self-Care Insufficiency Theory”. Patient data were collected according to all the steps included in the theory. Three main factors affected the patients self-care needs: COPD diagnosis, delirium, and agitation. Nursing interventions were planned and implemented based on these data.
Deconvoluting Low Yield from Weak Potency in Direct-to-Biology Workflows with Machine Learning
Authors: McCorkindale William , Filep Mihajlo , London Nir , Lee Alpha A. , King-Smith Emma
Published: December 2023

High throughput and rapid biological evaluation of small molecules is an essential factor in drug discovery and development. Direct-to-Biology (D2B), whereby compound purification is foregone, has emerged as a viable technique in time efficient screening, specifically for PROTAC design and biological evaluation. However, one notable limitation is the prerequisite of high yielding reactions to ensure the desired compound is indeed the compound responsible for biological activity. Herein, we report a machine learning based yield-assay deconfounder capable of deconvoluting low yield from low potency to identify false negatives. We validated this approach by identifying promising SARS-CoV-2 main protease inhibitors with nanomolar activity that rivaled potency observed from the standard D2B workflow. Furthermore, we show how our framework can be utilized in a broad, in silico screen with to produce compounds of similar potency as a D2B assay.
Encoding Protein-Ligand Interactions: Binding Affinity Prediction with Multigraph-based Modeling and Graph Convolutional Network
Authors: Mekni Nedra , Fooladi Hosein , Perricone Ugo , Langer Thierry
Published: December 2023

Machine learning models are employed to enhance the speed and provide novel insights in drug discovery due to their demonstrated effectiveness in predicting properties of small molecules like pKa, solubility, and binding affinity. These approaches accelerate drug discovery by helping researchers efficiently identify, prioritize, and optimize compounds. Nonetheless, when investigating properties that depend on the interaction between a ligand and its corresponding protein, a compelling need arises to incorporate the protein counterpart information within the models. Recently, graph neural networks (GNNs) have been developed to incorporate 3D structural information to improve our understanding of the underlying protein-ligand interactions. However, incorporating 3D information into GNNs is not always straightforward. To address the challenge, we introduce a model called InterGraph, which models the protein-ligand interaction as topological multigraphs. By leveraging a topological representation, InterGraph offers a comprehensive approach to a graph representation of the intricate spatial organization and connectivity patterns within protein-ligand systems. We introduce interaction spheres that assign varying edge densities, capturing the proximity-based influence of interactions. This approach enables us to capture the characteristics of the interaction network, filtering out the ones that are beyond 9 Å from the ligand since they are not considered relevant or established. Finally, we trained the model using a ligand binding dataset from PDBbind and tested it on a hold-out test set, achieving an RMSE value of 1.34. Our findings have demonstrated the power of the multigraph to encode the importance of close interactions, a factor that is relevant in the context of binding affinity. On average, our model accurately predicts binding affinity values for several protein-ligand complexes and exhibits higher accuracy for hydrolase, lyase, and families of proteins involved in mediating protein-protein interactions. Additionally, the Intergraph method displayed sensitivity to the binding mode when compared to a set of complexes that had undergone redocking calculations
Challenges Visually Impaired Students Face in Acquiring Fashion Skills: A Case Study among Visually Impaired Training Institutions in Ghana
Authors: Ogoe J. , Howard E. K. , Appiah N.
Published: December 2023

Purpose: This study explored the challenges visually impaired (VI) students face concerning fashion skill acquisition.

Design/Methodology/Approach: The research design was based on qualitative. The combination of purposive and snowball sampling techniques was chosen to ensure a diverse participant pool, capturing a range of perspectives on what visually impaired students face concerning fashion skill acquisition. Thematic analysis was employed to uncover patterns and themes, contributing to a rich understanding of the subject matter.

Findings: The findings revealed that the visually impaired are challenged by barriers to enrolment in fashion programmes, the cost-intensive nature of training, lack of sight, lack of skilled teachers and perceptions about Students with Visual Impairments (SVI) in Fashion. The study initiates further stakeholder discussions regarding designing a simplified inclusive curriculum to accommodate individuals with visually impaired and interested in enrolling on fashion courses.

The Research Limitation: Purposive and snowball sampling techniques may introduce selection bias, as participants are recruited based on specific criteria and through referrals. This may result in a sample that is more inclined to share similar perspectives, potentially overlooking the diversity of experiences within the visually impaired student community.

Practical Implication: Implementation of these practical measures can contribute to breaking down barriers and ensuring equal access to opportunities in the field of fashion for all students, regardless of visual ability.

Social Implication: Inclusive fashion education for the visually impaired has the potential of developing such individuals socially and economically thereby relieving the government of potential financial burden and reducing the social exclusion that the visually impaired experience.

Originality/ value:  The novelty of studying visually impaired students regarding fashion skill acquisition lies in its potential to uncover unique challenges, innovative solutions, and opportunities for inclusivity in education and vocational training.
Cavity preparation model in rat maxillary first molars: A pilot study
Authors: Ahmed Muna Sh , Mahdee Anas F , Mohammed Saifalarab
Published: December 2023

Objective: To conduct a standardized method for cavity preparation on the palatal surface of rat maxillary molars and to introduce a standardized method for tooth correct alignment within the specimen during the wax embedding procedure to better detect cavity position within the examined slides. Materials and methods: Six male Wistar rats, aged 4-6 weeks, were used. The maxillary molars of three animals were sectioned in the frontal plane to identify the thickness of hard tissue on the palatal surface of the first molar which was (250-300µm). The end-cutting bur (with a cutting head diameter of 0.2mm) was suitable for preparing a dentinal cavity (70-80µm) depth. Cavity preparation was then performed using the same bur on the tooth surface in the other three animals. Rats are then euthanized before dissecting, fixing, and demineralizing the teeth. For better alignment of teeth samples during the waxing procedure, K-file endodontic instrument size #8 was dipped in Indian ink. The file tip was inserted on the jaw bone at the buccal side of the tooth in a region opposed to the prepared cavity on the palatal side. Moreover, a small Dycal applicator instrument was used to mark the jaw bone on the mesial side of teeth samples as an orientation for the cutting surface. Results: Well-defined sections were obtained with a clear cavity extension within dentin and without any signs of pulp exposure in all samples. Conclusion: This pilot was conducted to perform an easy procedure for cavity preparation in rat molar teeth to obtain a clear histopathological section.
The influence of Simvastatin carried by Chitosan nanoparticle on bone regeneration using Masson’s Trichrome histochemical stain
Authors: Alsaeed Muna A , Al-Ghaban Nada MH , Karaibrahimoğlu Adnan
Published: December 2023

Background: Due to the complicated and time-consuming physiological procedure of bone healing, certain graft materials have been frequently used to enhance the reconstruction of the normal bone architecture. However, owing to the limitations of these graft materials, some pharmaceutical alternatives are considered instead.  Chitosan is a biopolymer with many distinguishing characteristics that make it one of the best materials to be used as a drug delivery system for simvastatin. Simvastatin is a cholesterol lowering drug, and an influencer in bone formation process, because it stimulates osteoblasts differentiation, bone morphogenic protein 2, and vascular endothelial growth factor. Objectives: histological, histochemical and histomorphometrical analyses were carried out to evaluate the  effect of local application of chitosan simvastatin nanoparticles (ChSimN) on bone healing. Materials and Methods: New Zealand rabbits (n=14) were used in this study.  Two defects were made: one on the right side (the experimental side) that received ChSimN and the other one on the left side (the control side), which left to heal spontaneously. Seven rabbits were sacrificed after 2 weeks of the experiments, while the others after 4 weeks.  Bone samples were taken for histological and histomorphometric study after the sacrifice. Results: The histological study, using both H&E and Masson’s Trichrome stain, revealed that the ChSimN group recorded an increased amount of bone formation at both time points. Histomorphometrical analysis recorded a significant increment in bone marrow and trabecular areas in the ChSimN group. Conclusion: ChSimN had a pronounced effect on bone formation.
Single-cell time series analysis reveals the dynamics of HSPC response to inflammation
Authors: Bouman Brigitte J , Demerdash Yasmin , Sood Shubhankar , Grünschläger Florian , Pilz Franziska , Itani Abdul R , Kuck Andrea , Marot-Lassauzaie Valérie , Haas Simon , Haghverdi Laleh , Essers Marieke AG
Published: December 2023

Hematopoietic stem and progenitor cells (HSPCs) are known to respond to acute inflammation; however, little is understood about the dynamics and heterogeneity of these stress responses in HSPCs. Here, we performed single-cell sequencing during the sensing, response, and recovery phases of the inflammatory response of HSPCs to treatment (a total of 10,046 cells from four time points spanning the first 72 h of response) with the pro-inflammatory cytokine IFNα to investigate the HSPCs’ dynamic changes during acute inflammation. We developed the essential novel computational approaches to process and analyze the resulting single-cell time series dataset. This includes an unbiased cell type annotation and abundance analysis post inflammation, tools for identification of global and cell type-specific responding genes, and a semi-supervised linear regression approach for response pseudotime reconstruction. We discovered a variety of different gene responses of the HSPCs to the treatment. Interestingly, we were able to associate a global reduced myeloid differentiation program and a locally enhanced pyroptosis activity with reduced myeloid progenitor and differentiated cells after IFNα treatment. Altogether, the single-cell time series analyses have allowed us to unbiasedly study the heterogeneous and dynamic impact of IFNα on the HSPCs.
Examining the Dynamic Nature of Pupils’ Educational Aspirations: A Longitudinal Mixed-model Study
Authors: Jokić Boris , Ristić Dedić Zrinka
Published: December 2023

This paper describes the results from a fully integrated longitudinal mixed model study examining the nature of, changes in, and interaction between the upper secondary and higher education aspirations of Croatian pupils. The research was carried out over two academic years in which pupils approached the transition from single-structure elementary (primary and lower secondary) education to differentiated upper secondary education. The qualitative part of the study centred on an in-depth exploration of the educational aspirations of 30 pupils from five schools using a series of 118 semi-structured interviews. The quantitative part consisted of repeated questionnaire administration (N=823) while pupils progressed to the final year of elementary education. Generalised Estimating Equations for Repeated Measures Outcome and Latent Curve Growth Modelling procedures indicate significant changes in upper secondary aspirations and stable higher education aspirations over time. Qualitative analyses indicate five patterns of upper secondary education aspirations and three patterns of higher education aspirations. Analysis of the interaction between aspirations at different educational levels suggests that upper secondary aspiration mediates a pupil’s aspiration for higher education. These results suggest that special effort is necessary in order to inform pupils about their educational options at both the upper secondary and higher education levels.
XGBoost machine learning algorithm for differential diagnosis of pediatric syncope
Authors: Kovalchuk Tetiana , Boyarchuk Oksana , Bogai Sviatoslav
Published: December 2023

Abstract. The search for new methods of differential diagnosis of syncope types will allow to improve the diagnosis of vasovagal syncope (VVS), syncope due to orthostatic hypotension (OH) and cardiac syncope (CS) in childhood in order to make timely adequate diagnostic and therapeutic decisions. The aim of the study was to develop an effective machine learning model for the differential diagnosis of VVS, syncope due to OH and CS in children. Materials and Methods. 140 patients with syncope, aged 8-17 years, were examined: 92 children with a diagnosis of VVS, 28 children with syncope due to OH and 20 children with CS. A machine learning model was built using XGBoost algorithm for multiclass classification based on input clinical, laboratory and instrumental patient data. Results. The developed machine learning model based on the XGBoost algorithm is effective in the differential diagnosis of VVS, syncope due to OH and CS, which is confirmed by the metrics of accuracy (0.93), precision (0.93 for VVS; 1.00 for syncope due to OH; 0.80 for CS), recall (0.96 for VVS; 1.00 for syncope due to OH; 0.67 for CS), f1 (0.95 for VVS; 1.00 for syncope due to OH; 0.73 for CS), ROC AUC (0.95 for VVS; 1.00 for syncope due to OH; 0.89 for CS), PR AUC (0.96 for VVS; 1.00 for syncope due to OH; 0.79 for CS),Cohen’s Kappa (0.85), and Matthews correlation coefficient (0.85). The most informative parameters of the syncope types differential diagnosis model are OH, paroxysmal supraventricular tachycardia, Hildebrandt coefficient, Calgary Syncope Seizure Score, vitamin B6, average duration of the P-Q interval during 24 hours, duration of tachycardia during 24 hours, stroke index, homocysteine, heart volume, and systolic blood volume. Conclusions. The proposed machine learning model has sufficient efficiency and can be used by pediatricians and pediatric cardiologists for the differential diagnosis of VS, syncope due to OH, and CS in childhood.
Educational Forum
Authors: Wilson Margaret , Deeks John
Published: December 2023

Courses and Seminars
New Zealand Industrial Relations Society: Extracts from the President's Annual Report 1976-77
Authors: Roth Bert
Published: December 2023

It is with pleasure that I present the fourth annual report of the New Zealand Industrial Relations Society. The past year has been one of mounting industrial conflict, with the largest number of stoppages since 1951, and consequently growing public concern with industrial relations. This has been reflected in the great increase in membership of our society, which has trebled during the past year, rising from 45 to 145. We are still a relatively small organisation, but with the establishment of a branch in Wellington we are at last becoming a truly national society.
Educational Forum
Authors: Wilson Margaret , Deeks John
Published: December 2023

In November, Bjorn Gustavsen, the Director of the Institute of Work Psychology, Oslo, will be visiting Wellington. He will be giving a public lecture, speaking at a University Staff Seminar and at a Workshop for trade unionists and management.
Booknotes
Authors: Wilson Margaret , Deeks John
Published: December 2023

Booknotes for Managing People for NZIG, A History of Industrial Legislation in New Zealand
Publications of Department of Labour and Indexes of the New Zealand Journal of Industrial Relations 1977
Authors: Roth Herbert
Published: December 2023

Publications of Department of Labour and Indexes of the New Zealand Journal of Industrial Relations 1977
Building bridges to protect health
Authors: Harvey Hillery
Published: December 2023

​This paper describes work under a Fellowship in Public Policy centred on enhanced partnerships among human, animal, and ecosystem health sectors in New Zealand. The outcome of the project is a guide to help protect the health of New Zealand’s people, production animals, wildlife, and environment by urging and guiding transdisciplinary interactions (Harvey 2010a).
Re: Publish or Perish: A new look at bibliometric statistics in the PBRF age
Authors: Tennant Craig
Published: December 2023

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Science, innovation and business
Authors: Carnaby Garth
Published: December 2023

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Innovators, innovation and increasing returns to scale: Solving New Zealand’s productivity paradox
Authors: Hendy Shaun , Sissons Catriona
Published: December 2023

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Hubungan antara Penggunaan Alat Perlindungan Diri (APD) dengan Tingkat Konsentrasi Kerja pada Perawat Ruang Isoler di RSUD dr. R. Soedjati Purwodadi
Authors: Pratama Susilo Budi , Syahardinata Yanuar Vigor , Faizin Chamim
Published: December 2023

Latar Belakang: Konsentrasi menjadi alternatif yang sangat penting sehingga dapat mengerjakan aktivitas sehari-hari. Ketika mengabaikan konsentrasi, dapat menimbulkan dampak yang sangat besar berupa adanya kecelakaan di-tempat kerja. Perawat ruang isoler perlu menggunakan APD, mengingat ling-kungan kerjanya memiliki potensi bahaya bagi kesehatan terlebih ditingkat konsentrasi kerja. Penelitian ini bertujuan untuk menganalisis adanya hu-bungan antara penggunaan Alat Perlindungan Diri (APD) dengan tingkat konsentrasi kerja pada perawat.Metode: Sampel penelitian yaitu perawat berjumlah 56 responden melalui metode total sampling. Instrumen penelitian menggunakan modul Grid Concentration Exercise. Penelitian bersifat kuantitatif observasional analitik dengan pendekatan cross-sectional. Analisis bivariat menggunakan APD dengan tingkat konsentrasi mempergunakan uji korelasi rank spearman.Hasil: Perawat dengan APD level I berjumlah 6 perawat atau (10,7%) memiliki tingkat konsentrasi sangat baik. Perawat dengan APD II berjumlah 36 (64,3%) perawat memiliki tingkat konsentrasi cukup baik, sementara pada APD III 14 perawat (25,00%) memiliki tingkat konsentrasi cukup. Ada hubungan yang signifikan antara penggunaan APD dengan tingkat konsentrasi kerja (p 0,000; r= -0,852).Kesimpulan: Penggunaan APD berhubungan dengan tingkat konsentrasi pera-wat. Semakin tinggi level penggunaan APD maka tingkat konsentrasi pada pera-wat ruang isoler semakin menurun.
ANALYSIS OF THE VALUE OF LOCAL WISDOM OF KAMPUNG NAGA BASED ON ENVIRONMENTAL PRESERVATION AS A COMMUNITY'S EFFORTS IN MANAGING THE ENVIRONMENT
Authors: Mulyanie Erni , Hilman Hakim Erwin , Indrianeu Tineu , Al Husaini Hamzah , Rismawati Resi
Published: December 2023

The life of Kampung Naga is a clear example of efforts to manage the environment through local wisdom which is still maintained, especially in inner Kampung Naga, so that the environment around us can provide many positive benefits to other living things. The purpose of this study was to examine local wisdom values based on environmental preservation in Kampung Naga as a community effort to keep their environmental beautiful. The research methode used is a qualitative descriptive approach. The data analysis used comes from observations, literature studies, and documentation. The Results of this study are that the people of Kampung Naga make efforts to preserve the environment by applying local wisdom based the environment, including forbidden forests, regional zoning, pamali, stilt house, and swales. The conclusion of this study is that local wisdom values based on environmental preservation are the way people protect their environment so that they can provide positive benefits for other living things.
SPATIAL ANALYSIS OF COVID-19 SPREAD PATTERN USING KERNEL DENSITY METHOD IN SURAKARTA
Authors: Wicaksono Dwi Agung , Papilaya Frederik Samuel
Published: December 2023

The COVID-19 pandemic caused by the SARS-CoV-2 virus, which spreads through the respiratory system and can cause respiratory problems, began in Wuhan, China, in December 2019 and quickly spread worldwide, including Indonesia. Surakarta experienced a significant increase in cases from April to June due to factors such as the celebration of Eid al-Fitr. The author used the Kernel Density method to map the spatial distribution of COVID-19 cases in Surakarta and to investigate the relationship between vaccination rates and positive patients. The methodology involved a quantitative descriptive study using secondary data from the Surakarta Health Agency in May 2021. Based on the research, it was found that there was no relationship between the achievement of the first dose of vaccination and the number of confirmed COVID-19 cases in the city of Surakarta. The spread of COVID-19 was more influenced by activities carried out by the community in public facilities or outdoor spaces, as well as compliance with the health protocols provided by the government.
MAKNA FILOSOFIS MOTIF SENI UKIR REK PALEMBANG
Authors: Hudaidah Hudaidah , Trianti Lilis , Rukmana Lisa
Published: December 2023

The wood carving motifs of Palembang, known as “rek,” have been a traditional craft since the era

of Srivijaya and continue to endure to this day. This craftsmanship holds high philosophical values

influenced by Hindu-Buddhist and Islamic cultures. Its uniqueness lies in the predominant use of golden

yellow color, and its carvings are exceptionally distinctive. The purpose of this writing is to unveil the

philosophical meanings embedded in the motifs of Palembang’s wood carvings. The central issue is to

explore the philosophical meanings of these motifs in Palembang’s wood carvings. This study employs a

historical research method, with heuristic, source criticism, interpretation, and historiography steps. The

tradition of wood carving art exhibits distinct characteristics and the uniqueness of various motifs, each

carrying different philosophical values. The research findings indicate that the various motifs found in

Palembang’s wood carvings hold profound philosophical meanings. For example, the motif of budding

bamboo shoots symbolizes that humans should be beneficial to others, and the golden color represents

triumph. Therefore, it is crucial to preserve this heritage for the younger generation so that they can

develop an appreciation for their local culture, strengthen personal values, and enhance their identity,

and self-awareness.

Keywords: Philosophical Meaning, Motif, Wood Carving, Typical of Palembang
PATHET SEBAGAI STRUKTUR ADEGAN WAYANG KULIT JAWATIMURAN SUBGAYA MALANGAN
Authors: Pangestu Dwi Cahyo , Suhita Raheni , Suryanto Edy
Published: December 2023

Malangan’s puppet is a shadow puppet that grows and develops in East Jawa, precisely in the Greater Malang

area. Malangan’s puppet differs from other styles in the scene structure department, which is covered by five

pathet (Javanese gamelan modes) concepts. The purpose of this research is to describe the structure of the

scene using five pathet concepts with the sample of the Malangan’s puppet script, Gathotkaca Lair. This

Study applied the descriptive qualitative method. The research data were drawn from the data source of the

Malangan’s puppet script with the Gathotkaca Lair’s play. The data collection employed content analysis

techniques by evaluating several character dialogues that represent the scene structure in each pathet. The

data analysis technique implemented the Miles & Huberman interactive model. The results of the study

suggest that the scene structure in the Gathotkaca Lair’s script is well packaged into five pathets. The five

pathets are pathet sepuluh (tenth), pathet wolu (eight), pathet sanga (ninth), pathet miring, and pathet

serang. Pathet sepuluh serves as the opening act, while pathet serang is the closing act.

Keywords: Structur of the Scene,, Malangan’s Puppet, Pathet
Cumhuriyet Döneminde İzmit İlçesi Gelişim Süreci ve Planlama Tarihi
Authors: AKTAŞ Songül , EFE GÜNEY Mercan , ECEMİŞ KILIÇ Sibel
Published: December 2023

Kentlerin gelişim sürecini belirleyen pek çok etken bulunmakla birlikte, kent planları hem bu etkenleri yönetmeye çalışan bir mekanizma olarak, hem de gereksinimleri karşılayarak geleceğe ilişkin öngörüde bulunan/kararlar alan bir bilim alanı olarak bu etkenlerin başında gelmektedir. Dolayısıyla bir kentin gelişim süreci içinde yapılmış planların incelenmesi planlama disiplininin ilkelerini ne kadar uygulamaya koyabildiğini ve sosyal, ekonomik ve kültürel unsurların planlama disiplinine nasıl etki ettiğini gösteren önemli bir araçtır. Bu kapsamda Kocaeli ili, İzmit ilçesi gelişim süreci yapılmış planlara göre irdelenmiştir. İzmit ilçesi sahip olduğu coğrafi avantajları ile Kocaeli kentinin gelişim sürecinin tamamının odağında yer aldığından çalışma alanı olarak seçilmiştir.

Çalışma kapsamında İzmit ilçesinin 1930’lu yıllarda başlayan planlama sürecinin incelenmesi ile kentin mekânsal dönüşümünde bu planların etkilerinin saptanması ve plan hiyerarşisi uyumunun incelenmesi amaçlanmıştır. İncelemelerle birlikte kentin makroformunun nasıl değiştiği, kent merkezinin kullanım kararlarının ve yapılaşma biçimlerinin nasıl dönüştüğü değerlendirilmiştir. Bu kapsamda İzmit ilçesine ilişkin geçmişte onaylanmış olan 1977,1979 ve 1984 yıllarına ait 1/1.000 ölçekli uygulama imar planları, 2008 yılında yürürlüğe giren 5747 sayılı “Büyükşehir Belediyesi Sınırları İçerisinde İlçe Kurulması ve Bazı Kanunlarda Değişiklik Yapılması Hakkında Kanun” ile İzmit belediyesi kurulmadan önce ilçe sınırları içinde yer alan (Kuruçeşme, Saraybahçe, Bekirpaşa, Alikahya, Akmeşe) belde belediyelerinin 1/5.000 ölçekli nazım ve 1/1.000 ölçekli uygulama imar planları ve güncel 1/25.000- 1/5.000 ölçekli nazım imar planları ile 1/1.000 ölçekli uygulama imar planları incelenmiştir.

Sonuçta İzmit ilçesinin planlama tarihi ortaya konulurken şehir planlama disiplininin temel ilkelerinden olan planlama hiyerarşisine uyulup uyulmadığı konusu İzmit ilçesi özelinde değerlendirilmiştir.