bluuebunny/crossref_metadata_2025 huggingface dataset:
Voxel-based meta-analysis of gray matter and white matter changes in patients with spinocerebellar ataxia type 3
Authors: Liu Hai , Lin Junyu , Shang Huifang
Published: July 2023

Purpose

Increasing neuroimaging studies have revealed gray matter (GM) and white matter (WM) anomalies of several brain regions by voxel-based morphometry (VBM) studies on patients with spinocerebellar ataxia type 3 (SCA3); however, the findings of previous studies on SCA3 patients by VBM studies remain inconsistent. The study aimed to identify consistent findings of gray matter (GM) and white matter (WM) changes in SCA3 patients by voxel-wise meta-analysis of whole-brain VBM studies.

Methods

VBM studies comparing GM or WM changes in SCA3 patients and healthy controls (HCs) were retrieved from PubMed, Embase, Web of Science, and Medline databases from January 1990 to February 2023. Manual searches were also conducted, and authors of studies were contacted for additional data. The coordinates with significant differences in GM and WM between SCA3 patients and HCs were extracted from each cluster. A meta-analysis was performed using anisotropic effect size-based signed differential mapping (AES-SDM) software.

Results

A total of seven studies comprising 160 SCA3 patients and 165 HCs were included in the GM volume meta-analysis. Three studies comprising 57 SCA3 patients and 63 HCs were included for WM volume meta-analysis. Compared with HC subjects, the reduced GM volume in SCA3 patients was found in the bilateral cerebellar hemispheres, cerebellar vermis, pons, right lingual gyrus, and right fusiform gyrus. The decreased WM volume was mainly concentrated in the bilateral cerebellar hemispheres, right corticospinal tract, middle cerebellar peduncles, cerebellar vermis, and left lingual gyrus. No increased density or volume of any brain structures was found. In the jackknife sensitivity analysis, the results remained largely robust.

Conclusion

Our meta-analysis clearly found the shrinkage of GM and WM volume in patients with SCA3. These lesions are involved in ataxia symptoms, abnormal eye movements, visual impairment, cognitive impairment, and affective disorders. The findings can explain the clinical manifestations and provide a morphological basis for SCA3.
Getting ahead of Alzheimer’s disease: early intervention with focused ultrasound
Authors: Noel Rebecca L. , Gorman Samantha L. , Batts Alec J. , Konofagou Elisa E.
Published: July 2023

The amyloid-β (Aβ) hypothesis implicates Aβ protein accumulation in Alzheimer’s disease (AD) onset and progression. However, therapies targeting Aβ have proven insufficient in achieving disease reversal, prompting a shift to focus on early intervention and alternative therapeutic targets. Focused ultrasound (FUS) paired with systemically-introduced microbubbles (μB) is a non-invasive technique for targeted and transient blood–brain barrier opening (BBBO), which has demonstrated Aβ and tau reduction, as well as memory improvement in models of late-stage AD. However, similar to drug treatments for AD, this approach is not sufficient for complete reversal of advanced, symptomatic AD. Here we aim to determine whether early intervention with FUS-BBBO in asymptomatic AD could delay disease onset. Thus, the objective of this study is to measure the protective effects of FUS-BBBO on anxiety, memory and AD-associated protein levels in female and male triple transgenic (3xTg) AD mice treated at an early age and disease state. Here we show that early, repeated intervention with FUS-BBBO decreased anxiety-associated behaviors in the open field test by 463.02 and 37.42% in male and female cohorts, respectively. FUS-BBBO preserved female aptitude for learning in the active place avoidance paradigm, reducing the shock quadrant time by 30.03 and 31.01% in the final long-term and reversal learning trials, respectively. Finally, FUS-BBBO reduced hippocampal accumulation of Aβ40, Aβ42, and total tau in females by 12.54, 13.05, and 3.57%, respectively, and reduced total tau in males by 18.98%. This demonstration of both cognitive and pathological protection could offer a solution for carriers of AD-associated mutations as a safe, non-invasive technique to delay the onset of the cognitive and pathological effects of AD.
The proteomic effects of ketone bodies: implications for proteostasis and brain proteinopathies
Authors: García-Velázquez Lizbeth , Massieu Lourdes
Published: July 2023

A growing body of evidence supports the beneficial effects of the ketone bodies (KBs), acetoacetate and β-hydroxybutyrate (BHB), on diverse physiological processes and diseases. Hence, KBs have been suggested as therapeutic tools for neurodegenerative diseases. KBs are an alternative fuel during fasting and starvation as they can be converted to Ac-CoA to produce ATP. A ketogenic diet (KD), enriched in fats and low in carbohydrates, induces KB production in the liver and favors their use in the brain. BHB is the most abundant KB in the circulation; in addition to its role as energy fuel, it exerts many actions that impact the set of proteins in the cell and tissue. BHB can covalently bind to proteins in lysine residues as a new post-translational modification (PTM) named β-hydroxybutyrylation (Kbhb). Kbhb has been identified in many proteins where Kbhb sites can be critical for binding to other proteins or cofactors. Kbhb is mostly found in proteins involved in chromatin structure, DNA repair, regulation of spliceosome, transcription, and oxidative phosphorylation. Histones are the most studied family of proteins with this PTM, and H3K9bhb is the best studied histone mark. Their target genes are mainly related to cell metabolism, chromatin remodeling and the control of circadian rhythms. The role of Kbhb on physiological processes is poorly known, but it might link KB metabolism to cell signaling and genome regulation. BHB also impacts the proteome by influencing proteostasis. This KB can modulate the Unfolded Protein Response (UPR) and autophagy, two processes involved in the maintenance of protein homeostasis through the clearance of accumulated unfolded and damaged proteins. BHB can support proteostasis and regulate the UPR to promote metabolism adaptation in the liver and prevent cell damage in the brain. Also, BHB stimulates autophagy aiding to the degradation of accumulated proteins. Protein aggregation is common to proteinopathies like Alzheimer’s (AD) and Parkinson’s (PD) diseases, where the KD and BHB treatment have shown favorable effects. In the present review, the current literature supporting the effects of KBs on proteome conformation and proteostasis is discussed, as well as its possible impact on AD and PD.
Ketonemia variability through menstrual cycle in patients undergoing classic ketogenic diet
Authors: Pasca Ludovica , Ferraris Cinzia , Guglielmetti Monica , Varesio Costanza , Totaro Martina , Trentani Claudia , Marazzi Claudia , Brambilla Ilaria , Ballante Elena , Armeno Marisa , Valenzuela Gabriela Reyes , Caraballo Roberto H. , Veggiotti Pierangelo , Tagliabue Anna , De Giorgis Valentina
Published: July 2023

Introduction

Ketogenic dietary therapies (KDT) are well-established, safe, non-pharmacologic treatments used for children and adults with drug-resistant epilepsy and other neurological disorders. Ketone bodies (KBs) levels are recognized as helpful to check compliance to the KDT and to attempt titration of the diet according to the individualized needs. KBs might undergo inter-individual and intra-individual variability and can be affected by several factors. Possible variations in glycemia and ketone bodies blood levels according to the menstrual cycle have not been systematically assessed yet, but this time window deserves special attention because of hormonal and metabolic related changes.

Methods

This study aims at searching for subtle changes in KBs blood level during menstrual cycle in female patients undergoing a stable ketogenic diet, by analyzing 3-months daily measurement of ketone bodies blood levels and glucose blood levels throughout the menstrual cycle.

Results

We report the preliminary results on six female patients affected by GLUT1DS or drug resistant epilepsy, undergoing a stable classic ketogenic diet. A significant increase in glucose blood levels during menstruation was found in the entire cohort. As far as the ketone bodies blood levels, an inversely proportional trend compared to glycemia was noted.

Conclusion

Exploring whether ketonemia variations might occur according to the menstrual cycle is relevant to determine the feasibility of transient preventive diet adjustments to assure a continuative treatment efficacy and to enhance dietary behavior support.

Clinical trial registration

clinicaltrials.gov, identifier NCT05234411.
Larotrectinib treatment for infantile fibrosarcoma in newborns: a case report and literature review
Authors: Wang Dandan , Zhang Fanhui , Feng Wanli , Pan Jiarong , Yuan Tianming
Published: July 2023

Infantile fibrosarcoma (IFS) is a rare tumor in childhood characterized by a single, localized, painless mass that grows rapidly but has a relatively indolent biological behavior and a favorable prognosis. Eighty-five percent of infantile fibrosarcomas are associated with t (12;15) (p13;25) chromosomal translocation resulting in ETV6-NTRK3 gene fusion, which provides the target for targeted therapy. Here, we report a case of IFS in a newborn with a mass in the left lower extremity confirmed by imaging, histopathological examination, tissue FISH testing, and high-throughput sequencing to detect gene rearrangement. Based on gene fusion targeted drug testing results, the patient was treated with standard doses of larotrectinib, resulting in significant mass shrinkage with no adverse effects, demonstrating the treatment effect of targeted therapy. This case provides a reference for using larotrectinib in newborns with IFS.
Salvage lenvatinib/everolimus combination therapy after immune checkpoint inhibitor and VEGFR tyrosine kinase inhibitor for metastatic renal cell carcinoma
Authors: Kwok Christopher , Khorasanchi Adam , Psutka Sarah P. , Hinkley Megan , Dason Shawn , Sundi Debasish , Yang Yuanquan , Yang Yajing , Verschraegen Claire , Gross Evan E. , Orcutt Delaney , Yin Ming
Published: July 2023

Background

The optimal treatment for metastatic renal cell carcinoma (mRCC) patients who have progressed after both immune checkpoint inhibitor (ICI) and VEGFR tyrosine kinase inhibitor (TKI) remains uncertain. Lenvatinib and everolimus (LE) are frequently used in combination as salvage therapy because of their different antitumor mechanisms, but efficacy and toxicity data in this setting are lacking.

Methods

We retrospectively reviewed charts from two academic centers for 71 adult mRCC patients who received LE after prior ICI and TKI exposure. We evaluated patient demographics, histology, International mRCC Database Consortium (IMDC) risk group, treatment history, and toxicity details. Outcomes of interest included objective response rate (ORR), time to treatment failure (TTF), overall survival (OS), ≥grade 3 toxicities, and schedule or dosage changes, which were evaluated using descriptive statistics, chi-square test, Cox proportional hazards model, and the Kaplan–Meier method.

Results

The median age was 64 (range 31–84). Most patients had clear cell histology (84.5%) and had undergone nephrectomy (80.3%). IMDC risks were favorable (19.7%), intermediate (int) (66.2%), poor (11.3%), and unknown (2.8%). The average ORR was 26.8%, while the median TTF was 5.5 months (95% confidence interval [CI], 3.5–7.6) and the median OS was 9 months (95% CI, 7.6–12.9). Intermediate and poor IMDC risks were independently associated with a significantly worse TTF compared to favorable risk (hazard ratio (HR), 3.03, 95% CI, 1.18–7.79), as was ≥4L treatment vs. 2L/3L treatment (HR, 2.02, 95% CI, 1.08–3.8). Of the 71 patients, 57.7% had ≥grade 3 adverse events, 60% had treatment interruption, 44.3% had dose reduction, and 21% stopped treatment due to intolerance.

Conclusions

LE therapy is feasible but has modest efficacies following ICI/TKI treatment. Patients with favorable risk or treated earlier may have a better treatment response. These observations need to be confirmed in prospective studies.
Incidence and risk factors of unplanned retreatment following dental general anesthesia in children with severe early childhood caries
Authors: Li Jin-yi , He Shu-yang , Wang Pan-xi , Dai Shan-shan , Zhang Shu-qi , Li Zheng-yang , Guo Qing-yu , Liu Fei
Published: July 2023

Objective

This study aimed to retrospectively describe the unplanned retreatment of dental general anesthesia (DGA) in children with severe early childhood caries (S-ECC) and explore potential factors that may influence the outcome of DGA treatment.

Methods

Medical records of children with S-ECC who received DGA treatment were screened, and necessary data were extracted. The Kaplan–Meier method and Cox proportional hazards model were used to estimate the DGA survival rate and explore the potential factors affecting the success rate of DGA treatment.

Results

Medical records of 852 children were included; 509 (59.7%) children with 1,212 (10.7%) teeth underwent unplanned retreatment. Restoration failure (30.12%) and new caries (29.46%) accounted for the most significant proportion of all failures. The median survival times were 510 and 1,911 days at the child and tooth levels, respectively. Unplanned retreatment risk was associated with the age of S-ECC children, frequency of follow-up, and fluoride application (hazard ratio = 0.97, 0.78, 0.69, P < 0.001).

Conclusion

The treatment outcome of DGA administered to children with S-ECC was satisfactory at the tooth level from the perspective of the incidence of unplanned retreatment. Restoration failure was the main reason for the high unplanned retreatment rate. Strategies for a better outcome of DGA include improving the professional knowledge and skills of pediatric dentists and enhancing compliance of parents/patients. Health education and regular topical fluoride application may improve the success rate of DGA treatment.
Genotype-phenotype correlation of WT1 mutation-related nephropathy in Chinese children
Authors: Chen Huanru , Zhang Miao , Lin Jinai , Lu Jieyi , Zhong Fazhan , Zhong Fu , Gao Xia , Liao Xin
Published: July 2023

Introduction

This study aimed to analyze the clinical characteristics of nephropathy associated with WT1 gene mutations in Chinese children and explore the relationship between genotype and clinical phenotype.

Methods

Cases diagnosed at the Guangzhou Women and Children's Medical Center, were combined with those retrieved from PubMed and China National Knowledge Infrastructure (CNKI) databases from January 2015 to June 2022 and integrated into a study cohort; grouped according to gene mutation sites, clinical phenotype, and renal pathological types. The clinical characteristics between groups were compared, and the relationship between genotype and age of onset, clinical phenotype, and pathological type were retrospectively analyzed.

Results

The center enrolled 15 confirmed children: seven cases of non-simple nephropathy, including Denys-Drash syndrome (DDS) and Frasier syndrome (FS); eight cases of isolated steroid-resistant nephrotic syndrome (ISRNS); and 13 cases (86.7%) that progressed to end-stage renal disease (ESRD). The initial hemoglobin and bicarbonate levels of patients with clinical non-simple nephropathy were significantly lower than those with simple nephropathy, whereas the serum creatinine levels were higher than those of patients with simple nephropathy. A total of 75 cases of nephropathy associated with WT1 mutations in the study cohort met the inclusion and exclusion criteria. The most common clinical manifestations of WT1 mutations in this cohort were DDS (29/75, 38.7%) and ISRNS (37/75, 49.3%). A renal biopsy was performed in 43 patients, and the common types of renal pathology were focal segmental glomerulosclerosis (23/43, 53.5%) and DMS (13/43, 30.2%). Within the cohort, there were 12 cases (16.0%) in the exon 8 mutation group, 32 (42.6%) in the exon 9 group, 19 (25.3%) in the intron 9 group, and 12 (16.0%) in other gene site mutation groups. Common sites of WT1 mutations in Chinese children were exons 9 and intron 9. Exon 8 mutations were uniquely correlated with the age of onset within three months [5/7; 71.4%; Adjusted standardized residual (AR) = 4.2]. The renal survival time in the exon 8 mutation group was the shortest (P = 0.003).

Discussion

The molecular and biological characteristics of WT1 mutation-related nephropathy determine the clinical type, pathological features, and renal survival time of the disease; and there was a strong correlation between the genotype and clinical phenotype.
Cost-effectiveness of maintenance niraparib with an individualized starting dosage in patients with platinum-sensitive recurrent ovarian cancer in China
Authors: Shi Yin , Xiao Di , Li Shuishi , Liu Shao , Zhang Yu
Published: July 2023

Objective: Niraparib improved survival in platinum-sensitive recurrent ovarian cancer (PSROC) patients versus routine surveillance, accompanied by increased costs. Based on the NORA trial, we evaluated for the first time the cost-effectiveness of maintenance niraparib with individualized starting dosage (ISD) in China.

Methods: A Markov model was developed to simulate the costs and health outcomes of each strategy. The total costs, quality-adjusted life years (QALYs), and incremental cost-effectiveness ratios (ICERs) were measured. One-way and probabilistic sensitivity analysis were performed to estimate model robustness. Scenario analyses were also conducted.

Results: Compared to routine surveillance, niraparib additionally increased QALYs by 0.59 and 0.30 in populations with and without germline BRCA (gBRCA) mutations, with incremental costs of $10,860.79 and $12,098.54, respectively. The ICERs of niraparib over routine surveillance were $18,653.67/QALY and $39,212.99/QALY. At a willingness-to-pay (WTP) threshold of $37,488/QALY, the ISD enhanced the likelihood of cost-effectiveness from 9.35% to 30.73% in the gBRCA-mutated group and from 0.77% to 11.74% in the non-gBRCA mutated population. The probability of niraparib being cost-effective in the region with the highest per capita Gross Domestic Product (GDP) in China was 74.23% and 76.10% in the gBRCA-mutated and non-gBRCA mutated population, respectively. Niraparib was 100% cost-effective for National Basic Medical Insurance beneficiaries under the above WTP thresholds.

Conclusion: Compared to routine surveillance, the ISD of niraparib for maintenance treatment of PSROC is cost-effective in the gBRCA-mutated population and more effective but costly in the non-gBRCA mutated patients. The optimized niraparib price, economic status, and health insurance coverage may benefit the economic outcome.
The identification of blood pressure variation with hypovolemia based on the volume compensation method
Authors: Chen Ruijuan , He Ming , Xiao Shumian , Wang Cong , Wang Huiquan , Xu Jiameng , Zhang Jun , Zhang Guang
Published: July 2023

Objective: The purpose of this study is to identify the blood pressure variation, which is important in continuous blood pressure monitoring, especially in the case of low blood volume, which is critical for survival.

Methods: A pilot study was conducted to identify blood pressure variation with hypovolemia using five Landrace pigs. New multi-dimensional morphological features of Photoplethysmography (PPG) were proposed based on experimental study of hemorrhagic shock in pigs, which were strongly correlated with blood pressure changes. Five machine learning methods were compared to develop the blood pressure variation identification model.

Results: Compared with the traditional blood pressure variation identification model with single characteristic based on single period area of PPG, the identification accuracy of mean blood pressure variation based on the proposed multi-feature random forest model in this paper was up to 90%, which was 17% higher than that of the traditional blood pressure variation identification model.

Conclusion: By the proposed multi-dimensional features and the identification method, it is more accurate to detect the rapid variation in blood pressure and to adopt corresponding measures.

Significance: Rapid and accurate identification of blood pressure variation under low blood volume ultimately has the potential to effectively avoid complications caused by abnormal blood pressure in patients with clinical bleeding trauma.
Overexpression of PSR1 in Chlamydomonas reinhardtii induces luxury phosphorus uptake
Authors: Slocombe Stephen P. , Zúñiga-Burgos Tatiana , Chu Lili , Mehrshahi Payam , Davey Matthew P. , Smith Alison G. , Camargo-Valero Miller Alonso , Baker Alison
Published: July 2023

Remediation using micro-algae offers an attractive solution to environmental phosphate (PO43-) pollution. However, for maximum efficiency, pre-conditioning of algae to induce ‘luxury phosphorus (P) uptake’ is needed. To replicate this process, we targeted the global regulator PSR1 (Myb transcription factor: Phosphate Starvation Response 1) for over-expression in algae. Manipulating a single gene (PSR1) drove uptake of both PO43- and a Mg2+ counter-ion leading to increased PolyP granule size, raising P levels 4-fold to 8% dry cell weight, and accelerated removal of PO43- from the medium. Examination of the gene expression profile showed that the P-starvation response was mimicked under P-replete conditions, switching on luxury uptake. Hyper-accumulation of P depended on a feed-forward mechanism, where a small set of ‘Class I’ P-transporter genes were activated despite abundant external PO43- levels. The transporters drove a reduction in external PO43- levels, permitting more genes to be expressed (Class II), leading to more P-uptake. Our data pointed toward a PSR1-independent mechanism for detection of external PO43- which suppressed Class II genes. This model provided a plausible mechanism for P-overplus where prior P-starvation elevates PSR1 and on P-resupply causes luxury P-uptake. This is because the Class I genes, which include P-transporter genes, are not suppressed by the excess PO43-. Taken together, these discoveries facilitate a bio-circular approach of recycling nutrients from wastewater back to agriculture.
Reliability and validity of the Chinese version of the Athletes’ Received Support Questionnaire
Authors: Yilin Ren , Kequn Chu , Fengshu Zhu
Published: July 2023

Objective

The aim of this study was to translate the Athletes’ Received Support Questionnaire (ARSQ) for Chinese athletes and examine the reliability and validity of the ARSQ with Chinese subjects.

Methods

In this study, we conducted a forward-backward translation of the ARSQ and used data collected from Chinese athletes to perform exploratory and confirmatory factor analyses. A total of 580 Chinese athletes completed the formal ARSQ for the confirmatory factor analysis (CFA), while 230 athletes participated in the preliminary survey. Of the 580 athletes, 571 provided valid questionnaires for assessing validity and reliability. Additionally, we assessed test–retest reliability using data from 200 participants randomly selected after 1 month. The criterion measurement used in this study was the Social Support Rate Scale (SSRS).

Results

Results of the exploratory factor analysis showed that the Chinese version of the ARSQ with 22 items had four-dimensional structures including emotional support, esteem support, information support, and tangible support. CFA showed that the Chinese version of the ARSQ had adequate structural validity (χ2/df = 2.315, CFI = 0.971, GFI = 0.902, NFI = 0.959, AGFI = 0.878, RMSEA = 0.064, SRMR = 0.032). Cronbach’s α coefficient, McDonald’s omega coefficient and the test–retest reliability were 0.956, 0.957, and 0.953 for the total scale.

Conclusion

The study provides evidence in support of construct (factorial) validity, convergent validity, internal-consistency and test–retest stability for the use of the ARSQ among Chinese athletes in the Jiangsu and Shandong Provinces, China. However, it is important to note that the conclusion is delimited to the current context, and further studies are needed to verify and promote the applicability of the ARSQ in other regions and sports projects.
On the outcomes of teacher wellbeing: a systematic review of research
Authors: Dreer Benjamin
Published: July 2023

Introduction

Teacher wellbeing is a growing area of research that has seen a steady increase in publications in recent years. The subsequent need to synthesize and structure this existing research has been articulated and addressed by a handful of systematic research reviews. However, no previous reviews have examined the potential outcomes of teacher wellbeing as a primary theme.

Methods

Following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, this review has identified and evaluated the studies investigating the possible outcomes of teacher wellbeing. A keyword search identified 397 records. After the records were screened, 44 research studies analyzing data from over 76,990 teachers were included in this in-depth analysis; the concepts, methods and findings of these studies were examined.

Results and discussion

The results of this review highlight the significant relationship of teacher wellbeing with several factors and desirable outcomes, including teachers' sleep quality, teacher retention, teacher–student relationships, and student outcomes. However, only a few of the included studies employed methodologies that support causal interpretations of these effects. In light of the present findings, this paper offers three main recommendations to support future progress in this field.
The effect of social media and infodemic on mental health during the COVID-19 pandemic: results from the COMET multicentric trial
Authors: Sampogna Gaia , Di Vincenzo Matteo , Luciano Mario , Della Rocca Bianca , Albert Umberto , Carmassi Claudia , Carrà Giuseppe , Cirulli Francesca , Dell’Osso Bernardo , Nanni Maria Giulia , Pompili Maurizio , Sani Gabriele , Tortorella Alfonso , Volpe Umberto , Fiorillo Andrea
Published: July 2023

On January 30, 2020, the World Health Organization (WHO) declared the status of pandemic due to the COVID-19 infection. The initial phases of the pandemic were characterized by uncertainty and public fears. In order to cope with such unexpected conditions, people adopted different coping strategies, including search for information, accessing Internet, and using social media. The present study based on the COMET collaborative research network aims to: (1) assess use of Internet and of social media among the Italian general population; (2) explore differences in web usage between people with pre-existing mental disorders and the general population; (3) identify changes over time in social media usage along the phase 1 of the pandemic; (4) identify the clinical, socio-demographic and contextual predictors of excessive use of social media. A significant increase in time spent on Internet, with an average time of 4.8  ±  0.02 h per day, was found in the global sample of 20,720 participants. Compared with the general population, Internet use was significantly higher in people with pre-existing mental disorders (5.2  ± 0.1 h vs. 4.9  ±  0.02; p < 0.005). According to the multivariate logistic regression model, the risk of excessive use of social media and Internet was significantly higher in people with moderate levels of depressive symptoms (OR: 1.26, CI 95%: 0.99 to 1.59, p < 0.0.005); while protective factors were being students (OR: 0.72, CI 95%: 0.53 to 0.96, p < 0.0029) and living in central Italy (OR: 0.46, CI 95%: 0.23 to 0.90, p < 0.002). The evaluation of social media and Internet use by the general population represents a first step for developing specific protective and supportive interventions for the general population, including practical suggestions on how to safely use Internet and social media.
Factor structure and psychometric properties of the Chinese version of the Odor Awareness Scale
Authors: Zhang Binfeng , Li Xiuxia , Tan Peixuan , Liu Yuxing , He Wanyong , Wang Lu , Huang Shuling , Nie Guanghui
Published: July 2023

Background

The Odor Awareness Scale (OAS) is a questionnaire that assesses individual differences in awareness of odors in the surrounding environment, which has been shown to be associated with affective symptoms in recent researches. To further research, A Chinese version of the OAS needs to be introduced.

Objective

To investigate the factor structure and validate the psychometric properties of the OAS.

Methods

A total of 978 participants from college were randomly allocated into two groups for exploratory factor analysis (EFA) and confirmatory factor analysis (CFA), respectively. Additionally, the study entailed item analysis and scrutinized internal consistency reliability, test-retest reliability, and concurrent validity. Test-retest reliability was assessed by having 214 participants complete the OAS twice at a one-week interval. Concurrent validity was measured using the Body Odor Sniffing Questionnaire (BOSQ), the Generalized Anxiety Disorder Scale (GAD-7), and the Toronto Alexithymia Scale (TAS-20).

Results

EFA identified three factors that best fit the data: odor sensitivity, odor impact, and odor attention. CFA validated a second-order factor model, yielding good fit indices: χ2/ Df = 2.326, RMSEA = 0.052, CFI = 0.911, TLI = 0.900, SRMR = 0.053. The final version of the OAS comprised 27 items and exhibited a commendable internal consistency reliability (Cronbach’s α = 0.913), and a good test-retest reliability, as evidenced by the high Pearson correlation coefficient (r = 0.940) and intraclass correlation coefficient (ICC = 0.940). The OAS was significantly correlated with BOSQ (r = 0.416), GAD-7 (r = 0.155), and TAS-20 (r = −0.081).

Conclusion

The Chinese version of the OAS demonstrated robust reliability and validity, rendering it a valuable instrument for evaluating odor awareness in the Chinese population.
Videos using different message strategies to promote the interruption of sedentary behavior in university students during online lectures – A pilot study
Authors: Doré Anastasia , Kalo Kristin , Schwab Lisa , Reichel Jennifer L. , Eisenbarth Laura , Strepp Tilmann , Jacob Robin , Enders Kira , Letzel Stephan , Simon Perikles , Dietz Pavel , Kubiak Thomas , Heller Sebastian
Published: July 2023

Background

Sedentary behavior (SB) is highly prevalent among university students and has increased during COVID-19 pandemic. As SB is associated with negative health outcomes, appropriate prevention measures in the university setting are needed.

Objective

This pilot study aimed at investigating the effects of videos using different message strategies to interrupt SB in the collective of university students during online lectures.

Methods

During online lectures, university students (N = 96) were shown one of three videos on the interruption of SB. The videos differed in their message strategies with regard to evidence type (statistical vs. narrative) and vividness (static vs. animated images). Demographics, health variables (SB intentions, SB attitudes) and selected media reception variables (identification, homophily, counterarguing) were examined as possible influence factors on the interruption of SB evoked by watching the video.

Results

Approximately half of the students interrupted sedentary behavior during watching the videos and students of the older age group (cut-off: median = 22 years) interrupted SB significantly more often (p = 0.046). The interruption of SB was predicted by SB intentions (p < 0.05). Identification with characters significantly predicted the intentions to reduce SB (p < 0.001), with a large effect of the overall regression model (R2corr = 0.47).

Conclusion

Considering the increased digitalization in general and restrictions due to COVID-19 pandemic, videos seem to be a useful tool to interrupt SB among university students during online lectures. Narrative formats could facilitate the intention to reduce SB, which in turn could have a positive impact on the interruption of SB. However, further research on effective communication and message strategies is needed.
Predictors of cancer screening behavior of the working population in China based on the information-motivation-behavioral skills model
Authors: Wang Zezhou , Zhou Changming , Zhang Li , Shen Jie , Mo Miao , He Yulian , Zheng Ying
Published: July 2023

Background

The cancer screening rate in the working population is very low in China. Information-motivation-behavioral skills (IMB) model has been applied to elucidate screening behavior for various chronic diseases but has not been investigated in analyzing cancer screening behavior. This study aimed to examine factors influencing cancer screening behavior and their linkages based on the IMB model.

Methods

A cross-sectional study was conducted in Shanghai, China from August to October 2021. Data were obtained through an anonymous questionnaire. Predictive relationships between variables in the IMB model and cancer screening behavior were evaluated. Structural equation modeling (SEM) was constructed to demonstrate the utility of the IMB model.

Results

Among the 556 participants included in the analysis, 34.4% of participants had ever done a cancer screening. The construct validation analysis supported that the measure items included were acceptable. SEM found that knowledge of cancer warning signs and symptoms (β = 0.563, p < 0.001) and cancer screening behavioral skills (β = 0.264, p = 0.003) were related to participation in cancer screening, whereas cancer screening motivation was not directly influenced the participation in cancer screening (β = − 0.075, p = 0.372).

Conclusion

The cancer screening rate was found to be lower than expected in the working population. The IMB model could be used to make decisions in implementing behavioral interventions to participate in cancer screening among the Chinese working population. Enhancing the knowledge of cancer warning signs and symptoms and strengthening behavioral skills should be focused on to improve participation in cancer screening.
Vaccine cold chain management practices in primary health centers providing an expanded immunization program in Northwest Ethiopia: self-reported and actual practice observational study
Authors: Ergetie Firdawek Shenkute , Kassaw Abebe Tarekegn , Sendekie Ashenafi Kibret
Published: July 2023

Background

Vaccines are vital health commodities that need an appropriate supply chain system. They could be transported, stored, and used at appropriate temperatures. The purpose of this study was to assess vaccine cold chain management practices in primary health centers offering an expanded program of immunization (EPI) in Bahir Dar, Northwest Ethiopia.

Methods

A self-reported and actual practice observational cross-sectional study was conducted at primary public health centers in the Bahir Dar city administration from August 15 to 30, 2021. A simple random sampling method was used to select study participants. An interview-administered questionnaire and direct actual practice observation were used to collect data. The data was entered into the Epi-data 4.6 program and analyzed using SPSS version 25. Participants’ knowledge, storage and transport conditions, IPLS management, and vaccine cold chain management practices were examined using independent samples t-tests and one-way ANOVA tests.

Findings

A total of 50 respondents from ten health centers were enrolled in the study. Most of the EPI service providers had good knowledge (60%) and good practice in vaccine storage and transport (74%). However, more than two-thirds (68%) of EPI service providers had poor integrated pharmaceutical logistics system (IPLS) management. Only half (50%) of the health centers had good actual vaccine cold chain management practices. Higher educational background, longer work experience, and receiving training and supervision in EPI services, IPLS management, and vaccine inventory management resulted in higher knowledge, storage and transport management, IPLS management, and vaccine cold chain management practices.

Conclusion

Although most EPI service providers in an interview assessment reported having good knowledge and good vaccine storage and transport management, only half of the health facilities followed the standard. Stakeholders are recommended to play a vital role in improving practices related to EPI services.
Assessment of consumers’ knowledge, attitude and perception of the impact of the COVID-19 pandemic on household food security in Caribbean Small Island Developing States
Authors: Daley Oral , Roopnarine Ronald , Isaac Wendy-Ann P. , Palmer Donald , John Afiya , Webb Marquitta , Dalrymple Nequesha , Maharaj Omardath
Published: July 2023

Introduction

The COVID-19 pandemic and recent international crises including the Russia-Ukraine conflict have resulted in significant disruptions along multiple segments of the Caribbean’s agri-food system, thus compromising regional food security. These impacts are still ongoing with the potential to worsen. The aim of this study was to investigate the influence of sociodemographic factors on consumers’ knowledge of food security along with their attitude, and perception towards the impact of the COVID-19 pandemic on household food security in the Caribbean Small Island Developing States.

Method

A cross-sectional on-line survey was conducted between January 1 and November 30, 2021. The sampled population included consumers from nine Caribbean countries (Trinidad and Tobago, Barbados, Jamaica, Antigua and Barbuda, Dominica, Grenada, St. Kitts and Nevis, St. Lucia, and St. Vincent and the Grenadines). Survey data were analyzed using Chi-square, one way analysis of variance, and univariate logistic regression.

Results and discussion

A total of 237 consumers participated in the survey. Consumers were generally knowledgeable about food security and had favorable attitudes and perceptions of the impact of the COVID-19 pandemic on household food security. Significant associations (p<0.05) and significant differences (p<0.05) were obtained for consumers’ knowledge, attitude and perception among the sociodemographic variables assessed. The results suggest that there were different levels of vulnerability to food insecurity associated with the COVID-19 pandemic, particularly among economically vulnerable households. Policies that support disadvantaged households and ensure adequate employment opportunities are important to support Caribbean consumers throughout and post the COVID-19 pandemic recovery.
Building relationships back into the food system: addressing food insecurity and food well-being
Authors: Verfuerth Caroline , Sanderson Bellamy Angelina , Adlerova Barbora , Dutton Amy
Published: July 2023

Introduction

Failures of the current food system sit at the core of the multitude of crises by being the root framework for both consumption choices and food production. Low-income households are disproportionately affected by these failures, impacting their food security and access to healthy and sustainable foods. Community-supported agriculture (CSA) is a bottom-up response towards an agri-food system transformation by providing an alternative food system based on agroecologically grown food that is sold locally and rooted in social values. Alongside other food citizenship movements and alternative food networks (AFN), CSAs are driven by the vision to develop a democratic, socially and economically just, and environmentally sustainable food system. Yet, low-income households are underrepresented in the CSA community.

Method

Our paper presents findings from a co-produced intervention between the research team, four CSA farms based in Wales, United Kingdom and two food aid partners that sought to identify ways to improve the accessibility of CSA memberships for food-insecure households. Thirty-eight households received a weekly veg bag for a period of 2–4 months. We interviewed 16 household members at the project start and end of the harvest season. Building on the food well-being framework, we investigate impacts of a CSA membership on food-insecure households.

Results

We found that CSA membership holistically improves food well-being, through strengthening producer-consumer relationships, increasing availability of healthy foods, helping people to care for their own and their families well-being, and building place-based food capability and literacy.

Discussion

This paper supports wider narratives that call for systematically prioritizing interventions that promote overall food well-being, which can lead to sustainable and just food systems with positive outcomes for financially excluded, food insecure households in localized AFNs.
Omentectomy for oncological surgical staging by transvaginal natural orifice transluminal endoscopic surgery (vNOTES): a preliminary study
Authors: Hurni Yannick , Huber Daniela
Published: July 2023

Objective

This study aimed to determine the feasibility of performing omentectomy by transvaginal natural orifice transluminal endoscopic surgery (vNOTES) for surgical staging of ovarian and high-risk endometrial malignancies.

Methods

This descriptive study was realized in a non-university hospital in Switzerland. Eighteen patients with suspicious adnexal masses or high-risk endometrial cancer underwent surgical staging comprising infracolic omentectomy by vNOTES between May 2020 and April 2023.

Results

Patients underwent oncological surgical staging for suspicious adnexal masses in 14 cases (77.8%) and high-risk endometrial cancer in 4 cases (22.2%). vNOTES omentectomies were performed in all patients without complications. Associated procedures included salpingo-oophorectomy (94.4%), hysterectomy (55.6%), peritoneal biopsies (33.3%), pelvic sentinel lymph node biopsies (22.2%), and appendectomy (5.6%). The median time to perform omentectomies was 9 (4–13) min. All oncological staging were completed by vNOTES. No significant intraoperative complications occurred. We observed 1 case (5.6%) of postoperative fever probably associated with vaginal cuff infection (Clavien-Dindo grade II).

Conclusions

This study demonstrated the feasibility of performing vNOTES oncological staging requiring complex extrapelvic procedures such as infracolic omentectomy, supporting its potential role for managing gynecological malignancies such as ovarian and high-risk endometrial cancers. However, before expanding this approach outside study settings, strong evidence of its feasibility, practical benefits, and long-term oncological outcomes are needed.
Accreditation in continuing veterinary education: development of an accreditation system and selection of accreditation criteria
Authors: Kareskoski Maria
Published: July 2023

With the increased supply and demand of veterinary continuing education (CE) and the growing number of CE providers, a clear need has arisen for a multinational accreditation system for veterinary CE. The objective of this document is to describe the current state of veterinary CE accreditation and the development of an accreditation system for veterinary CE, and discuss accreditation criteria and their pedagogical and practical significance. The hypothesis is that a profile of essential, pedagogically grounded, accreditation criteria can be established and utilized effectively in quality assessment. Accreditation criteria for veterinary CE can be created based on four selection principles: educational minimum requirements, coherence, efficacy, and assessability. The selected educational quality criteria are related to needs assessment, correlation of target audience and level of instruction, definition of scope, workload, and number of credits, organizer and instructor qualifications, constructive alignment, assessment of learning, learner engagement, and scientific quality of CE content. The created accreditation criteria and protocols should be regularly re-evaluated and modified in close collaboration with the relevant stakeholders. The desired outcome of CE, including behavior change and improvement of practice and ultimately human and animal health, remains challenging to predict based on course descriptions by the providers, and further research is needed.
An Algorithm for Construction of the Asymptotic Approximation of a Stable Stationary Solution to a Diffusion Equation System with a Discontinuous Source Function
Authors: Nefedov Nikolay , Tishchenko Bogdan , Levashova Natalia
Published: July 2023

An algorithm is presented for the construction of an asymptotic approximation of a stable stationary solution to a diffusion equation system in a two-dimensional domain with a smooth boundary and a source function that is discontinuous along some smooth curve lying entirely inside the domain. Each of the equations contains a small parameter as a factor in front of the Laplace operator, and as a result, the system is singularly perturbed. In the vicinity of the curve, the solution of the system has a large gradient. Such a problem statement is used in the model of urban development in metropolitan areas. The discontinuity curves in this model are the boundaries of urban biocenoses or large water pools, which prevent the spread of urban development. The small parameter is the ratio of the city’s outskirts linear size to the whole metropolis linear size. The algorithm includes the construction of an asymptotic approximation to a solution with a large gradient at the media interface as well as the steps for obtaining the existence conditions. To prove the existence and stability theorems, we use the upper and lower solutions, which are constructed as modifications of the asymptotic approximation to the solution. The latter is constructed using the Vasil’yeva algorithm as an expansion of a small parameter exponent.
My Practice of Re-Patterning My Art
Authors: Vasudevan Pramila
Published: July 2023

This essay shares the various ways in which my socio-political context and health background has impacted my journey as an artist and culture worker through my work with the Aniccha Arts collaborative in the Twin Cities. I would like to share how my (un/re)learnings have materialized into different movement textures of togetherness over the years. I describe how I arrived at creating the current movement-based project, Prairie|Concrete, and the questions that I am asking as a path forward.