bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacogenomics: A Genetic Approach to Drug Development and Therapy
Authors: Qahwaji Rowaid , Ashankyty Ibraheem , Sannan Naif S. , Hazzazi Mohannad S. , Basabrain Ammar A. , Mobashir Mohammad
Published: July 2024

The majority of the well-known pharmacogenomics research used in the medical sciences contributes to our understanding of medication interactions. It has a significant impact on treatment and drug development. The broad use of pharmacogenomics is required for the progress of therapy. The main focus is on how genes and an intricate gene system affect the body’s reaction to medications. Novel biomarkers that help identify a patient group that is more or less likely to respond to a certain medication have been discovered as a result of recent developments in the field of clinical therapeutics. It aims to improve customized therapy by giving the appropriate drug at the right dose at the right time and making sure that the right prescriptions are issued. A combination of genetic, environmental, and patient variables that impact the pharmacokinetics and/or pharmacodynamics of medications results in interindividual variance in drug response. Drug development, illness susceptibility, and treatment efficacy are all impacted by pharmacogenomics. The purpose of this work is to give a review that might serve as a foundation for the creation of new pharmacogenomics applications, techniques, or strategies.
In Vitro Biological Evaluation of an Alginate-Based Hydrogel Loaded with Rifampicin for Wound Care
Authors: Bibire Tudor , Dănilă Radu , Yilmaz Cătălina Natalia , Verestiuc Liliana , Nacu Isabella , Ursu Ramona Gabriela , Ghiciuc Cristina Mihaela
Published: July 2024

We report a biocompatible hydrogel dressing based on sodium alginate-grafted poly(N-vinylcaprolactam) prepared by encapsulation of Rifampicin as an antimicrobial drug and stabilizing the matrix through the repeated freeze–thawing method. The hydrogel structure and polymer-drug compatibility were confirmed by FTIR, and a series of hydrogen-bond-based interactions between alginate and Rifampicin were identified. A concentration of 0.69% Rifampicin was found in the polymeric matrix using HPLC analysis and spectrophotometric UV–Vis methods. The hydrogel’s morphology was evaluated by scanning electron microscopy, and various sizes and shapes of pores, ranging from almost spherical geometries to irregular ones, with a smooth surface of the pore walls and high interconnectivity in the presence of the drug, were identified. The hydrogels are bioadhesive, and the adhesion strength increased after Rifampicin was encapsulated into the polymeric matrix, which suggests that these compositions are suitable for wound dressings. Antimicrobial activity against S. aureus and MRSA, with an increased effect in the presence of the drug, was also found in the newly prepared hydrogels. In vitro biological evaluation demonstrated the cytocompatibility of the hydrogels and their ability to stimulate cell multiplication and mutual cell communication. The in vitro scratch assay demonstrated the drug-loaded alginate-grafted poly(N-vinylcaprolactam) hydrogel’s ability to stimulate cell migration and wound closure. All of these results suggest that the prepared hydrogels can be used as antimicrobial materials for wound healing and care applications.
Advances in Nanomedicine for Precision Insulin Delivery
Authors: Caturano Alfredo , Nilo Roberto , Nilo Davide , Russo Vincenzo , Santonastaso Erica , Galiero Raffaele , Rinaldi Luca , Monda Marcellino , Sardu Celestino , Marfella Raffaele , Sasso Ferdinando Carlo
Published: July 2024

Diabetes mellitus, which comprises a group of metabolic disorders affecting carbohydrate metabolism, is characterized by improper glucose utilization and excessive production, leading to hyperglycemia. The global prevalence of diabetes is rising, with projections indicating it will affect 783.2 million people by 2045. Insulin treatment is crucial, especially for type 1 diabetes, due to the lack of β-cell function. Intensive insulin therapy, involving multiple daily injections or continuous subcutaneous insulin infusion, has proven effective in reducing microvascular complications but poses a higher risk of severe hypoglycemia. Recent advancements in insulin formulations and delivery methods, such as ultra-rapid-acting analogs and inhaled insulin, offer potential benefits in terms of reducing hypoglycemia and improving glycemic control. However, the traditional subcutaneous injection method has drawbacks, including patient compliance issues and associated complications. Nanomedicine presents innovative solutions to these challenges, offering promising avenues for overcoming current drug limitations, enhancing cellular uptake, and improving pharmacokinetics and pharmacodynamics. Various nanocarriers, including liposomes, chitosan, and PLGA, provide protection against enzymatic degradation, improving drug stability and controlled release. These nanocarriers offer unique advantages, ranging from enhanced bioavailability and sustained release to specific targeting capabilities. While oral insulin delivery is being explored for better patient adherence and cost-effectiveness, other nanomedicine-based methods also show promise in improving delivery efficiency and patient outcomes. Safety concerns, including potential toxicity and immunogenicity issues, must be addressed, with the FDA providing guidance for the safe development of nanotechnology-based products. Future directions in nanomedicine will focus on creating next-generation nanocarriers with precise targeting, real-time monitoring, and stimuli-responsive features to optimize diabetes treatment outcomes and patient safety. This review delves into the current state of nanomedicine for insulin delivery, examining various types of nanocarriers and their mechanisms of action, and discussing the challenges and future directions in developing safe and effective nanomedicine-based therapies for diabetes management.
Engineered Exosomes Biopotentiated Hydrogel Promote Hair Follicle Growth via Reprogramming the Perifollicular Microenvironment
Authors: Zhang Hairui , Yao Jiali , Jiang Qianyang , Shi Yurou , Ge Weihong , Xu Xiaoling
Published: July 2024

Androgenetic alopecia (AGA) is a highly prevalent condition in contemporary society. The conventional treatment of minoxidil tincture is hindered by issues such as skin irritation caused by ethanol, non-specific accumulation in hair follicles, and short retention due to its liquid form. Herein, we have developed a novel minoxidil-incorporated engineered exosomes biopotentiated hydrogel (Gel@MNs) that has the capability to modulate the perifollicular microenvironment for the treatment of AGA. Leveraging the exceptional skin penetration abilities of flexible liposomes and the targeting properties of exosomes, the encapsulated minoxidil can be effectively delivered to the hair follicles. In comparison to free minoxidil, Gel@MNs demonstrated accelerated hair regeneration in an AGA mouse model without causing significant skin irritation. This was evidenced by an increase in both the number and size of hair follicles within the dermal layer, enhanced capillary formation surrounding the follicles, and the regulation of the transition of hair follicle cells from the telogen phase to the anagen growth phase. Therefore, this safe and microenvironment-modifying hybrid exosome-embedded hydrogel shows promising potential for clinical treatment of AGA.
Design and Optimization of Sesamol Nanosuspensions to Potentiate the Anti-Tumor Activity of Epirubicin against Ehrlich Solid Carcinoma-Bearing Mice
Authors: Elzanaty Kholoud A. , Omran Gamal A. , Elmahallawy Ehab Kotb , Albrakati Ashraf , Saleh Ayman A. , Dahran Naief , Alhegaili Alaa S. , Salahuddin Ahmad , Abd-El-Azim Heba , Noreldin Ahmed , Okda Tarek M.
Published: July 2024

There is a growing interest in discovering natural sources of anti-cancer drugs. Sesamol (SES) is a phenolic compound with antitumor effects. The present study aimed to investigate the anticancer properties of SES and its nano-suspensions (SES-NS) combined with Epirubicin (EPI) in breast cancer (BC) using mice bearing a solid Ehrlich tumor. The study involved 35 female albino mice and investigated the effects of SES and EPI on tumor growth, proliferation, apoptosis, autophagy, angiogenesis, and oxidative stress. Methods including ELISA, qRT-PCR, and immunohistochemistry were utilized. The findings revealed reductions in tumor growth and proliferation using SES either alone or combined and evidenced by decreased AKT (AKT Serine/Threonine kinase1) levels, angiogenesis indicated by lower levels of VEGFR (vascular endothelial growth factor), and apoptosis demonstrated by elevated caspase3 and BAX levels. Furthermore, autophagy increased and was indicated by increased levels of beclin1 and lc3, along with decreased oxidative stress as evidenced by elevated TAC (total antioxidant capacity) and reduced MDA (malondialdehyde) levels. Interestingly, SES-NS demonstrated more significant effects at lower doses. In summary, this study underscores the potential of SES as a promising agent for BC treatment. Moreover, SES-NS potentiated the beneficial effects of EPI while mitigating its adverse effects.
Targeting Liver Xor by GalNAc-siRNA Is an Effective Strategy for Hyperuricemia Therapy
Authors: Sun Huiyan , Wang Xinxia , Li Yongqiang , Shen Yingzhi , Zhang Lin , Xu Yingjie , Liu Junling , Fan Xuemei
Published: July 2024

Hyperuricemia, i.e., increased plasma uric acid concentration, is a common problem in clinical practice, leading to gout or nephrolithiasis, and is associated with other disorders, such as metabolic syndrome, cardiovascular disease, and chronic renal disease. Xanthine oxidoreductase (XOR) is a critical rate-limiting enzyme involved in uric acid synthesis and a promising target for hyperuricemia therapy. However, XOR inhibitors currently face clinical problems such as a short half-life and side effects. Here, we found that specifically targeting liver Xor with GalNAc-siRNAs had a good therapeutic effect on hyperuricemia. First, siRNAs were designed to target various sites in the homologous region between Homo sapiens and Mus musculus Xor mRNA and were screened in primary mouse hepatocytes. Then, the siRNAs were modified to increase their stability in vivo and conjugated with GalNAc for liver-specific delivery. The effects of GalNAc-siRNAs were evaluated in three hyperuricemia mouse models, including potassium oxonate and hypoxanthine administration in WT and humanized XDH mice and Uox knockout mice. Febuxostat, a specific XOR inhibitor used for hyperuricemia treatment, was used as a positive control. Targeting liver Xor with GalNAc-siRNAs by subcutaneous administration reduced plasma uric acid levels, uric acid accumulation in the kidney, renal inflammation, and fibrosis, thereby alleviating kidney damage in hyperuricemia mouse models without hepatoxicity. The results demonstrated that targeting liver Xor with GalNAc-siRNAs was a promising strategy for hyperuricemia therapy.
α-Lactalbumin mRNA-LNP Evokes an Anti-Tumor Effect Combined with Surgery in Triple-Negative Breast Cancer
Authors: He Yun-Ru , Xia Heng , Yun Peng , Xu Yuandong , Ma Winson M. J. , Xiao Ze-Xiu , Zha Gao-Feng
Published: July 2024

Triple-negative breast cancer (TNBC) has been considered a huge clinical unmet need due to its aggressive progression and highly frequent metastasis. mRNA therapeutics supply a potential and versatile immunotherapy of oncology treatment. Here, we developed α-lactalbumin mRNA-lipid nanoparticles (α-LNP) as a potential therapeutical strategy for TNBC. The α-LNP induced the specific IgG antibodies and activated IFN γ-secreting-T cells in vivo. Additionally, the safety of α-LNP also had been demonstrated in vivo. When vaccinated prior to tumor implantation, α-LNP showed a preventive effect against 4T1 tumor growth and extended the survival of the tumor model by activating the memory immune responses. Furthermore, α-LNP administration in combination with surgical removal of neoplasm effectively inhibited the progression and metastasis in the TNBC model. Taken together, our results indicate that the α-LNP vaccine is a promising novel treatment for both therapeutics and prophylactics in TNBC.
Chemodynamic Therapy of Glioblastoma Multiforme and Perspectives
Authors: Ullah Zia , Abbas Yasir , Gu Jingsi , Ko Soe Sai , Roy Shubham , Peng Tingting , Guo Bing
Published: July 2024

Glioblastoma multiforme (GBM), a potential public health issue, is a huge challenge for the advanced scientific realm to solve. Chemodynamic therapy (CDT) based on the Fenton reaction emerged as a state-of-the-art therapeutic modality to treat GBM. However, crossing the blood–brain barrier (BBB) to reach the GBM is another endless marathon. In this review, the physiology of the BBB has been elaborated to understand the mechanism of crossing these potential barriers to treat GBM. Moreover, the designing of Fenton-based nanomaterials has been discussed for the production of reactive oxygen species in the tumor area to eradicate the cancer cells. For effective tumor targeting, biological nanomaterials that can cross the BBB via neurovascular transport channels have also been explored. To overcome the neurotoxicity caused by inorganic nanomaterials, the use of smart nanoagents having both enhanced biocompatibility and effective tumor targeting ability to enhance the efficiency of CDT are systematically summarized. Finally, the advancements in intelligent Fenton-based nanosystems for a multimodal therapeutic approach in addition to CDT are demonstrated. Hopefully, this systematic review will provide a better understanding of Fenton-based CDT and insight into GBM treatment.
Polarization Influence on Er3+-Doped Multi-Wavelength Brillouin Fiber Laser Based on Fiber Loop Mirror
Authors: Hao Yunqi , Miao Miao , Liao Weitong , Yang Kun
Published: July 2024

Polarization influences on the performance of multi-wavelength Brillouin Er3+-doped fiber laser are investigated by adjusting the polarization controller (PC) in the fiber loop mirror (FLM), where the linear laser cavity is composed of a fiber-tailed mirror and an FLM, and the stimulated Brillouin scattering (SBS) and the Er3+-doped fiber amplification (EDFA) simultaneously serve as the cavity gain. We realized 1–7 Brillouin laser lines by increasing the 980 nm pump power. For the first-order Brillouin laser, the signal–noise ratio (SNR) and optical intensity present a sinusoidal envelope; the conversion efficiency changes significantly from 0.56465 dBm/mw to 0.44975 dBm/mw by adjusting the ring’s angle in the PC; the first-order SBS thresholds are 20.4 mw, 36.1 mw and 28.5 mw at different angles θ2 = 36°, 276° and 300°, respectively; flatness between the two Brillouin lasers change obviously from 2.863 dB to 41.801 dB with different ring angles; the second-order Brillouin laser is suppressed and disappears finally at Δθ2 = −64° to −84° and 106°~136° angle variation. For the fifth-order Brillouin laser, the highest-order Brillouin laser line is seriously suppressed until it disappears at some angle variations similarly. The powers and wavelength stabilities for one-, three- and seven-wavelength Brillouin fiber lasers were measured in 1 h, and the obtained Er3+-doped multi-wavelength Brillouin fiber laser (MWBFL) worked stably during that time, but the stabilities become worse with higher SBS orders.
Symmetry-Engineered Dual Plasmon-Induced Transparency via Triple Bright Modes in Graphene Metasurfaces
Authors: Cao Yanrui , Sang Tian
Published: July 2024

Dynamical manipulation of plasmon-induced transparency (PIT) in graphene metasurfaces is promising for optoelectronic devices such as optical switching and modulating; however, previous design approaches are limited within one or two bright/dark modes, and the realization of dual PIT windows through triple bright modes in graphene metasurfaces is seldom mentioned. Here, we demonstrate that dual PIT can be realized through a symmetry-engineered graphene metasurface, which consists of the graphene central cross (GCC) and graphene rectangular ring (GRR) arrays. The GCC supports a bright mode from electric dipole (ED), the GRR supports two nondegenerate bright modes from ED and electric quadrupole (EQ) due to the C2v symmetry breaking, and the resonant coupling of these three bright modes induces the dual PIT windows. A triple coupled-oscillator model (TCM) is proposed to evaluate the transmission performances of the dual PIT phenomenon, and the results are in good agreement with the finite-difference time-domain (FDTD) method. In addition, the dual PIT windows are robust to the variation of the structural parameters of the graphene metasurface except for the y-directioned length of the GRR. By changing the carrier mobility of graphene, the amplitudes of the two PIT windows can be effectively tuned. The alteration of the Fermi level of graphene enables the dynamic modulation of the dual PIT with good performances for both modulation degree (MD) and insertion loss (IL).
The Greasy Pole Syndrome in Alliaria petiolata (Brassicaceae): The Pubescence and Wax Coverage on Stems Reduce Invasion by Lasius niger Ants
Authors: Gorb Elena V. , Gorb Stanislav N.
Published: July 2024

To reduce negative effects of floral visitation by ants, which do not serve as reliable cross-pollinators, some plants have developed a non-floral, stem-based defense mechanism called greasy pole syndrome. In the present study, we examined the effects of two surface features (trichomes and three-dimensional epicuticular wax coverage) on stems of Alliaria petiolata plants on visiting frequencies, travelled distances, and running velocities of Lasius niger ants. The experiments were performed with stem samples prepared from different (apical and basal) stem portions showing different surface morphologies (smooth control, covered by wax and trichomes + wax, respectively). The control, mechanically wiped stem samples lacking any surface features were significantly more often visited by ants, where they travelled significantly longer distances and moved with significantly higher velocities, compared to the intact stems. The apical and basal stem portions showed no significant differences in the measured parameters. Based on data obtained, we conclude about the main contribution of the wax to the greasy pole function of the A. petiolata stem via reduction of ant adhesion to the wax-bearing stem surface, whereas trichomes presumably serve as the first barrier for ants approaching usually from the ground level and protect the fragile wax coverage from an excessive deterioration.
Metabolic Response of the Lycium barbarum Variety ‘Ningqi No. 7′ to Drought Stress
Authors: Liu Xiao , Wang Chuanzhe , Xu Qiao , Zhao Dan , Liu Fei , Han Beibei
Published: July 2024

Lycium barbarum has been widely planted in arid and semi-arid areas due to its drought-resistant ability, which is of great economic value as a medicinal and edible homology plant. In this study, the metabolome of the L. barbarum variety “Ningqi 7” under different drought stress conditions was compared and analyzed by the non-targeted UPLC-MS (ultra-high performance liquid chromatography with mass spectrometry) technique. The results showed that drought stress significantly decreased the water content of leaves, increased the activity of antioxidant enzymes in plants, and up-regulated the metabolites and pathways involved in osmoregulation, antioxidant stress, energy metabolism, and signal transduction. Under moderate drought (40–45% FC), L. barbarum accumulated osmoregulatory substances mainly through the up-regulation of the arginine metabolism pathway. At the same time, phenylalanine metabolism and cutin, suberine, and wax biosynthesis were enhanced to improve the antioxidant capacity and reduce water loss. However, in severe drought (10–15% FC), L. barbarum shifted to up-regulate purine metabolism and lysine degradation and redistributed energy and nitrogen resources. In addition, vitamin B6 metabolism was significantly upregulated in both groups of stress levels, playing a key role in antioxidant and growth regulation. These observations delineate the metabolic adaptations of L. barbarum “Ningqi 7” in response to drought stress.
Oil/Water Biphasic Solvent System for the Eco-Extraction and Cosmetic Formulation of Bixa orellana L.
Authors: Chambaud Marine , Fournier Ariane , De Saint Jores Clément , Caux Benjamin , Colas Cyril , Destandau Emilie
Published: July 2024

Annatto, obtained from the seeds of achiote (Bixa orellana L.), is a widely used orange pigment rich in bixin and other apocarotenoids. This work reports the optimisation of a green extraction method of pigments and antioxidant compounds from achiote as well as its integration in a one-step green extraction-cosmetic formulation process. A biphasic solvent system of water and oil was used to recover simultaneously polar polyphenols, and less polar compounds, such as δ-tocotrienol and bixin. The optimisation of the ultrasound assisted extraction is presented, as well as a comparison of different vegetable oils used as extraction solvents. The composition, physicochemical properties and antioxidant activity of the oils were studied and their extraction performance was compared. Refined sunflower oil proved to be a better solvent than virgin olive, jojoba, coconut and grapeseed oils. Both aqueous and oil phases displayed an interesting antioxidant capacity. The oil phase contained 0.9% of bixin, as well as minor apocarotenoids and δ-tocotrienol. Twelve compounds, mainly phenolics, were identified by UHPLC-DAD-HRMS/MS in the aqueous phase. Twenty-one volatile compounds were identified in the volatile fraction by SPME-GC-MS. Lastly, a one-step green process is proposed to combine the extraction and the cosmetic formulation of the bioactive compounds.
An Overview of Advanced Antimicrobial Food Packaging: Emphasizing Antimicrobial Agents and Polymer-Based Films
Authors: Upadhyay Punita , Zubair Muhammad , Roopesh M. S. , Ullah Aman
Published: July 2024

The food industry is increasingly focused on maintaining the quality and safety of food products as consumers are becoming more health conscious and seeking fresh, minimally processed foods. However, deterioration and spoilage caused by foodborne pathogens continue to pose significant challenges, leading to decreased shelf life and quality. To overcome this issue, the food industry and researchers are exploring new approaches to prevent microbial growth in food, while preserving its nutritional value and safety. Active packaging, including antimicrobial packaging, has gained considerable attention among current food packaging methods owing to the wide range of materials used, application methods, and their ability to protect various food products. Both direct and indirect methods can be used to improve food safety and quality by incorporating antimicrobial compounds into the food packaging materials. This comprehensive review focuses on natural and synthetic antimicrobial substances and polymer-based films, and their mechanisms and applications in packaging systems. The properties of these materials are compared, and the persistent challenges in the field of active packaging are emphasized. Specifically, there is a need to achieve the controlled release of antimicrobial agents and develop active packaging materials that possess the necessary mechanical and barrier properties, as well as other characteristics essential for ensuring food protection and safety, particularly bio-based packaging materials.
Exploring the Equilibrium State Diagram of Maltodextrins across Diverse Dextrose Equivalents
Authors: Saavedra-Leos Zenaida , Carrizales-Loera Anthony , Lardizábal-Gutiérrez Daniel , López-Martínez Laura Araceli , Leyva-Porras César
Published: July 2024

This study investigates the equilibrium state diagram of maltodextrins with varying dextrose equivalents (DE 10 and 30) for quercetin microencapsulation. Using XRD, SEM, and optical microscopy, three transition regions were identified: amorphous (aw 0.07–0.437), semicrystalline (aw 0.437–0.739), and crystalline (aw > 0.739). In the amorphous region, microparticles exhibit a spherical morphology and a fluffy, pale-yellow appearance, with Tg values ranging from 44 to −7 °C. The semicrystalline region shows low-intensity diffraction peaks, merged spherical particles, and agglomerated, intense yellow appearance, with Tg values below 2 °C. The crystalline region is characterized by fully collapsed microstructures and a continuous, solid material with intense yellow color. Optimal storage conditions are within the amorphous region at 25 °C, aw 0.437, and a water content of 1.98 g H2O per g of dry powder. Strict moisture control is required at higher storage temperatures (up to 50 °C) to prevent microstructural changes. This research enhances understanding of maltodextrin behavior across diverse dextrose equivalents, aiding the development of stable microencapsulated products.
Valorization of Sugarcane Bagasse for Co-Production of Poly(3-hydroxybutyrate) and Bacteriocin Using Bacillus cereus Strain S356
Authors: Khamberk Sunisa , Thammasittirong Sutticha Na-Ranong , Thammasittirong Anon
Published: July 2024

Poly(3-hydroxybutyrate) (P(3HB)) is an attractive biodegradable plastic alternative to petroleum-based plastic. However, the cost of microbial-based bioplastic production mainly lies in the cultivation medium. In this study, we screened the isolates capable of synthesizing P(3HB) using sugarcane bagasse (SCB) waste as a carbon source from 79 Bacillus isolates that had previously shown P(3HB) production using a commercial medium. The results revealed that isolate S356, identified as Bacillus cereus using 16S rDNA and gyrB gene analysis, had the highest P(3HB) accumulation. The highest P(3HB) yield (5.16 g/L, 85.3% of dry cell weight) was achieved by cultivating B. cereus S356 in an optimal medium with 1.5% total reducing sugar with SCB hydrolysate as the carbon source and 0.25% yeast extract as the nitrogen source. Transmission electron microscopy analysis showed the accumulation of approximately 3–5 P(3HB) granules in each B. cereus S356 cell. Proton nuclear magnetic resonance spectroscopy and Fourier transform infrared spectroscopy analyses confirmed that the polymer extracted from B. cereus S356 was P(3HB). Notably, during cultivation for P(3HB) plastic production, B. cereus S356 also secreted bacteriocin, which had high antibacterial activity against the same species (Bacillus cereus). Overall, this work demonstrated the possibility of co-producing eco-friendly biodegradable plastic P(3HB) and bacteriocin from renewable resources using the potential of B. cereus S356.
Creep Failure Characteristics and Mathematical Modeling of High-Density Polyethylene Geomembranes under High Stress Levels
Authors: Wang Libo , Cen Weijun , Bauer Erich , Wei Jiangliang , Wen Zhenyu , Yan Jun
Published: July 2024

To explore the creep characteristics of geomembrane under different tensile stresses, a series of creep tests were carried out on high-density polyethylene (HDPE) geomembrane specimens. For the interpretation and fitting of the experimental data, refined approximation functions were proposed. Particular attention was paid to the creep failure behavior under high tensile stresses, i.e., 70%, 80%, and 90% of maximum peak stress. To investigate the effects of size on the mechanical response, experiments with two different membrane thicknesses were conducted. The results obtained under high stress levels were compared with creep tests at medium and low stress levels. Depending on load level, different creep characteristics can be distinguished. In the secondary creep state, the creep velocity is higher for higher load levels. In contrast to the medium and low load levels, the geomembrane under high stresses underwent the tertiary creep stage after instantaneous deformation and primary and secondary creep stages. In some tests, it was observed that under very high stress levels, creep velocity does not necessarily follow the expected trend and creep rupture can occur within a short time. For numerical simulation, an improved mathematical model was proposed to reproduce in a unified manner the experimental data of the whole non-linear evolution of creep elongation under different stress levels.
Helium Geochemical Characteristics and Favorable Zones in the Tarim Basin: Implications for Helium Exploration
Authors: Yang Haijun , Li Pengpeng , Zhang Haizu , Lv Jiahao , Zhang Wen , Liu Jiarun , Huang Shaoying , Yang Xianzhang , Yuan Wenfang , Wang Xiang
Published: July 2024

Helium is an irreplaceable ore resource for many applications, such as nuclear magnetic resonance, aviation, semiconductors, and nuclear energy. Extracting helium in a free state from natural gas is currently the only economical approach at the industrial level. In this study, we compiled geochemical data of 719 natural gas samples from 36 oil and gas fields in the Tarim basin that include experimental results and previously reported data. Helium is of primarily crustal origin in the Tarim Basin according to helium isotope characteristics (not exceeding 0.1 Ra), except in the Ake gas field that has not more than 7% of mantle helium. Helium concentrations in diverse tectonic units vary considerably. Oil-type gas, on the whole, has a higher helium concentration relative to coal-type gas. Abundant helium flux, a favorable fault system between the source-reservoir system, no strong charging of gaseous hydrocarbons, and the good sealing capacity are important factors that control the formation of helium-rich gas fields. Considering both the helium concentration and natural gas reserves, helium-rich gas fields located in the Southwest Depression and Tabei Uplift can be regarded as the major favorable zones of further deployment for helium extraction.
Kinetics of Vanillin and Vanillic Acid Production from Pine Kraft Lignin
Authors: Dos Santos Ricardo Javier , Vallejos María Evangelina , Area María Cristina , Felissia Fernando Esteban
Published: July 2024

Vanillin (4-hydroxy-3-methoxybenzaldehyde) is the main component of natural vanilla and a relevant substance in the flavoring and aromatic industries. This study presents a kinetic model to explain both vanillin and vanillic acid concentrations achieved in the alkaline oxidation of pine kraft lignin. Considering that they come from the same precursors, this approach allows an understanding of vanillin production with reaction conditions that minimize the vanillic acid pathway directly from the lignin oligomers, thus maximizing vanillin production. This study involves the effects of oxygen partial pressure, temperature, and the presence or absence of a catalyst (CuSO4 and Fe2(SO4)3 mixture) on the vanillin and vanillic acid yields. An adapted reactor (M/K Systems Inc., Williamstown, MA, USA) with a recirculation and spray liquids system was used in the experiments. The experiments were performed using one liter of a solution of NaOH 2 M and 60 g of lignin. During the lignin oxidation reaction, liquid samples were analyzed at different times (from 0 to 200 min). The oxidation products were quantified by liquid chromatography (HPLC). The catalyzed experiments presented higher maximum vanillin yields than the non-catalyzed ones (39.2–39.6% on nitrobenzene oxidation) achieved at 150 °C. A kinetic model is proposed where the kinetic parameters were estimated using Monte Carlo methods, fitting satisfactorily to the experimental results. The statistical analysis of the kinetic parameters showed that all the studied variables significantly affect the vanillin yield.
Assessment of Solid Waste Management and Decarbonization Strategies
Authors: Chiang Ping Fa , Zhang Tengling , Claire Mugabekazi Joie , Maurice Ndungutse Jean , Ahmed Jabran , Giwa Abdulmoseen Segun
Published: July 2024

Global population growth, industrialization, and urbanization have led to a dramatic increase in solid waste (SW) generation, which is considered a main environmental pollutant via greenhouse gas (GHG) emissions and soil and groundwater contamination. This creates serious problems for the region and the world at large. Currently, about 2 billion tons of SW are generated globally every year, of which 67% is processed by various treatment technologies, while 33% is freely released into the environment. Therefore, there is an urgent need to significantly reduce GHG emissions from global SW production for the maximization of climate benefits and to halt the continued rise in temperature. Fortunately, this can be attained with the use of existing SW processing methods and improved performance. Through a comprehensive literature review, this research evaluates the effectiveness of various SW approaches, including source reduction, recycling, and energy recovery. Additionally, this study examines the potential of emerging technologies and their integration and innovative solutions to enhance solid waste management (SWM) systems and promote decarbonization. The findings highlight the significant environmental and economic benefits of implementing integrated SWM strategies that prioritize waste prevention, material recovery, and energy generation from waste. Furthermore, this study emphasizes the importance of stakeholder engagement, policy interventions, and public awareness campaigns in fostering sustainable waste management practices. By adopting a holistic approach that considers the entire waste management lifecycle, this review provides valuable insights and recommendations for policymakers, waste management authorities, and communities to achieve sustainable waste management and contribute to global decarbonization efforts.
Filtered Right Coprime Factorization and Its Application to Control a Pneumatic Cylinder
Authors: Tanabata Yusaku , Deng Mingcong
Published: July 2024

The main objective of this research is to expand right coprime factorization based on operator theory in nonlinear systems. A novel method for right coprime factorization is proposed by introducing an operator that can deform the system’s response into an arbitrary shape. This enables the design of control systems that are highly effective against noise. As an application, we use a pneumatic stage. The effectiveness of this method is verified through simulations and real-world experiments.
Impacts of CO2-CH4 Mixed Gas on Property of Formation Oil from the Bohai Oilfield
Authors: Yang Renfeng , Zhang Lijun , Tan Xianhong , Tian Xiaofeng , Yang Xugang , Shu Xiaohan , Zou Guodong , Yang Erlong , Jiang Changdong , Hu Shaobin
Published: July 2024

Mechanism analysis and technical scheme optimization on CO2 displacement and CO2 storage are based on the high-pressure physical properties of CO2-added formation oil. Oil and natural gas samples from the BZ25-1 block in the Bohai oilfield were used to conduct high-pressure physical property experiments to explore the impacts of CO2-CH4 mixed gas on the properties of formation oil. After injecting different amounts of mixed gas, the saturated pressure was measured by constant mass expansion test, the viscosity was measured by falling ball method, the expansion coefficient was measured by gas injection expansion test, and the gas–oil ratio and volume coefficient were obtained by single degassing test. The results show that with gas injection, the saturation pressure and dissolved gas–oil ratio of formation oil increase, the volume coefficient and expansion factor go up, while the oil viscosity reduces. With the increase in gas addition, the properties of formation oil continue to improve, but the increase in improvement becomes flat. With the increase in pressure, the amount of dissolved gas in the formation oil will also increase. High-purity CO2 is more helpful to change the properties of formation oil, while the gas mixed with CH4 is more beneficial to elevate the formation energy. For the BZ 25-1 block, the gas injection amount of about 80 mol% is appropriate and the CO2 purity of 60% can well balance the oil properties improvement and the formation pressure elevation.
Research on an Adaptive Active Suspension Leveling Control Method for Special Vehicles
Authors: Zhang Pan , Yue Huijun , Zhang Pengchao , Gu Jie , Yu Hongjun
Published: July 2024

Adaptive active suspension systems, integral to specialized vehicles, hold significance for their stability and safety. This study introduces a novel adaptive active suspension system featuring four independently controlled wheels employing wheel-hub motors, hydraulic cylinders, pump motor power, controllers, and sensors. A rapid and, within a certain range, leveling and height adjustment control strategy is proposed for this system, utilizing the Kalman filter algorithm. Additionally, the paper examines the front-wheel Ackermann steering model and four-wheel reverse Ackermann transition model to enhance the suspension’s stability. Subsequently, experiments on leveling and height adjustment are conducted, demonstrating the system’s capability to swiftly and accurately rectify the vehicle’s deviation angle within the specified threshold. Following adjustments made by the leveling and height control algorithm, the vehicle body promptly returns to the preset level state and designated height. The leveling control system holds broad applicability in intelligent agriculture, logistics handling, off-road equipment, and other domains, presenting significant practical utility.
Fault Diagnosis Method of Bearings Based on SCSSA-VMD-MCKD
Authors: Lv Qing , Zhang Kang , Wu Xiancong , Li Qiang
Published: July 2024

To tackle the issue of detecting early, subtle faults in rolling bearings in the presence of noise interference, the SCSSA-VMD-MCKD method is suggested. This method optimizes the Variational Mode Decomposition (VMD) and Maximum Correlated Kurtosis Deconvolution (MCKD) by integrating the sine-cosine and Cauchy Mutation Sparrow Search Algorithm (SCSSA). The approach aims to effectively diagnose faults in rolling bearings by leveraging the strengths of VMD and MCKD in noise reduction and highlighting fault frequencies. The method utilizes the SCSSA algorithm to autonomously search for parameters in both VMD and MCKD, using the EnvelopeCrest Factor Ec as a fitness function. Firstly, SCSSA is employed to optimize the decomposition mode number K and penalty factor α in the VMD algorithm. Secondly, the parameters in the MCKD algorithm are optimized, and MCKD is used for deconvolution to enhance the impulsive characteristics of the best modal component. Finally, the signal is further analyzed after deconvolution. The results demonstrate that this algorithm can effectively identify subtle fault signals in bearing signals and diagnose fault frequencies in noisy environments. The accuracy of fault diagnosis can reach nearly 99%.
Investigation of the Effectiveness of Barrier Layers to Inhibit Mutagenic Effects of Recycled LDPE Films, Using a Miniaturized Ames Test and GC-MS Analysis
Authors: Prielinger Lukas , Bandyopadhyay Smarak , Ortner Eva , Novak Martin , Radusin Tanja , Annfinsen Steffen , Sharmin Nusrat , Rainer Bernhard , Pettersen Marit Kvalvåg
Published: July 2024

To fulfil the European Green Deal targets and implement a circular economy, there is an urgent need to increase recycling rates of packaging materials. However, before recycled materials can be used in food contact applications, they must meet high safety standards. According to the European Food Safety Authority (EFSA), a worst-case scenario must be applied and unknown substances must be evaluated as being potentially genotoxic. The Ames test, which detects direct DNA-reactive effects, together with chromatographic analysis is very promising to complement risk assessment. This study aims to evaluate the effectiveness of functional barriers in ten different samples, including virgin and recycled LDPE foils. FT-IR analysis did not show major differences between virgin and recycled films. Light microscopy revealed differences in quality and an increased number of particles. GC-MS analysis detected and quantified 35 substances, including eight unknowns. Using a miniaturized version of the Ames test, four of ten samples tested positive in two individual migrates up to a dilution of 12.5%. All virgin LDPE materials tested negative; however, recycled material F showed an increased mutagenic activity, with an n-fold induction up to 28. Samples with functional barriers lowered migration and reduced mutagenicity. Nonetheless, further investigations are needed to identify possible sources of contamination.
Recent Developments in Technology for Sorting Plastic for Recycling: The Emergence of Artificial Intelligence and the Rise of the Robots
Authors: Lubongo Cesar , Bin Daej Mohammed A. A. , Alexandridis Paschalis
Published: July 2024

Plastics recycling is an important component of the circular economy. In mechanical recycling, the recovery of high-quality plastics for subsequent reprocessing requires plastic waste to be first sorted by type, color, and size. In chemical recycling, certain types of plastics should be removed first as they negatively affect the process. Such sortation of plastic objects at Materials Recovery Facilities (MRFs) relies increasingly on automated technology. Critical for any sorting is the proper identification of the plastic type. Spectroscopy is used to this end, increasingly augmented by machine learning (ML) and artificial intelligence (AI). Recent developments in the application of ML/AI in plastics recycling are highlighted here, and the state of the art in the identification and sortation of plastic is presented. Commercial equipment for sorting plastic recyclables is identified from a survey of publicly available information. Automated sorting equipment, ML/AI-based sorters, and robotic sorters currently available on the market are evaluated regarding their sensors, capability to sort certain types of plastics, primary application, throughput, and accuracy. This information reflects the rapid progress achieved in sorting plastics. However, the sortation of film, dark plastics, and plastics comprising multiple types of polymers remains challenging. Improvements and/or new solutions in the automated sorting of plastics are forthcoming.
Towards a Holistic Buddhist Eco-Ethics
Authors: Wang Juan , Tan Joan Qionglin
Published: July 2024

The debate on Buddhist eco-ethics emerged in the late 20th century and continues to the present day, which fosters the intersection of Buddhist eco-ethics with environmental ethics. However, the current understanding of Buddhist eco-ethics still falls short of a holistic concept. To fill the gap, this paper argues that different macro perspectives should be considered in the process of developing a concept of holistic Buddhist eco-ethics. For this, we firstly attempt to clarify the dispute over the feasibility of Buddhist eco-ethics from the internal, external, and Buddhists’ perspectives. Then, we address the dispute concerning the classification of Buddhist eco-ethics, proposing a typology that accommodates different perspectives. Finally, two methods are suggested to mediate the dispute over Buddhist eco-ethics and justify its holistic concept, that is, regarding Buddhist eco-ethics as a form of virtue ethics and as a product of “engaged Buddhism.” Here, it is also emphasized to include Buddhists’ perspectives when mediating the dispute. Accordingly, we put forward a holistic concept for Buddhist eco-ethics that incorporates three main macro perspectives: ecological ethics in Buddhism, Buddhism in ecological ethics, and Buddhists’ environmental activities. It is hoped that the wisdom of Buddhist eco-ethics can help us forge a path towards a more harmonious and sustainable world in the near future.
The Protestant Reformation as an Islamisation of Christianity in the Thought of Ziya Gökalp and Ali Shariati
Authors: Gil Guerrero Javier
Published: July 2024

Following Ziya Gökalp and Ali Shariati’s assertion that Protestantism arose due to the influence of Islam in Europe in the Middle Ages, this study discusses the different discourses elaborated by the Turkish and Iranian authors based on this idea. The controversies surrounding modernity, westernization, colonialism, and Islam were a constant in their writings, despite the different geographical and historical circumstances. This paper discusses the logic of Gökalp and Shariati’s claim that Protestantism was Islamized Christianity. The aim is to provide a detailed perspective on how this claim illuminates their broader thinking about civilization, culture, and religion.
Dialogues on the Issues of Theodicy in Late Ming Fujian
Authors: Xiao Qinghe
Published: July 2024

This paper aims to illustrate the dialogues on the issues of theodicy in late Ming Fujian. The Catholicism that entered China in the late Ming dynasty had a competitive relationship with indigenous religions in terms of their meaning systems. Catholicism emphasized the omniscience, omnibenevolence, and omnipotence of God, which created tensions and contradictions with the reality of phenomena such as the suffering of good people and the existence of evil. In the late Ming period, scholars, believers, and missionaries in the Fujian region engaged in deep exchanges and dialogues on theodicy, reflecting the significant attention and consideration given to the problem of evil. This paper first analyzes the dialogues on theodicy between the Fujian scholar Ye Xianggao (1559–1627) and the missionary Giulio Aleni (1582–1649). Next, it explores the discussions on the problem of evil between ordinary believers in the Fujian region and Giulio Aleni in their daily lives. Finally, it examines how anti-Catholics used the problem of evil to criticize Catholicism, and it also identifies the characteristics and impacts of Catholic theodicy in the late Ming and early Qing periods.
Cruise Speed Model Based on Self-Attention Mechanism for Autonomous Underwater Vehicle Navigation
Authors: Mu Xiaokai , Yi Yuanhang , Zhu Zhongben , Zhu Lili , Wang Zhuo , Qin Hongde
Published: July 2024

This study proposes a cruise speed model based on the Self-Attention mechanism for speed estimation in Autonomous Underwater Vehicle (AUV) navigation systems. By utilizing variables such as acceleration, angle, angular velocity, and propeller speed as inputs, the Self-Attention mechanism is constructed using Long Short-Term Memory (LSTM) for handling the above information, enhancing the model’s accuracy during persistent bottom-track velocity failures. Additionally, this study introduces the water-track velocity information to enhance the generalization capability of the network and improve its speed estimation accuracy. The sea trial experiment results indicate that compared to traditional methods, this model demonstrates higher accuracy and reliability with both position error and velocity error analysis when the used Pathfinder DVL fails, providing an effective solution for AUV combined navigation systems.
Imaging Seafloor Features Using Multipath Arrival Structures
Authors: Su Zhaohua , Zhuo Jie , Sun Chao
Published: July 2024

In this paper, we propose an imaging method for seafloor features based on multipath arrival structures. The bistatic sonar system employed consists of a vertical transmitting array and a horizontal towed array. The conventional back projection (BP) method, which considers the direct path from the source to the seafloor scatterer and then to the receiver, is used in this system. However, discrepancies between the calculated delay values and the actual propagation delay result in projection deviations and offsets in the seafloor features within sound intensity images. To address this issue, we analyze the multipath structures from the source to the scatterer and then to the receiver based on ray theory. The delay at each grid is calculated using different multipaths, considering the distances from the seafloor grids to the source and the receiver. In the direct zone, the delay is determined using the direct ray and the surface reflection ray, while in the bottom bounce area, the delay is calculated using the bottom–surface reflection ray and the surface–bottom–surface reflection ray. Numerical simulations and experimental results demonstrate that the proposed method rectifies the delay calculation issues inherent in the conventional method. This adjustment enhances the accuracy of the projection, thereby improving the imaging quality of seafloor features.