bluuebunny/crossref_metadata_2025 huggingface dataset:
Antihypertensive Drugs and Psoriasis
Authors: Konigsberg Matthew , Albahrani Yasser
Published: April 2018

Psoriasis can cause patients to have an increased risk of cardiovascular disease, including hypertension. Many psoriasis patients being treated for hypertension have had adverse reactions to the antihypertensive drugs, causing their psoriasis to return. In some patients without known psoriasis, hypertension medications even brought about new instances of psoriasis. In this paper, we review the literature describing cases of reactions (mainly negative] in psoriasis patients taking antihypertensive medications. We examine different classes of hypertension medications, including ACE inhibitors, beta-blockers, and calcium channel blockers. Since there have been so many reported incidents, physicians using antihypertensive drugs for patients with psoriasis should consider the implications of using each type of drug, and should use this information to prescribe a less-reactive drug type if possible.
Safety and Efficacy of Cyclosporine in Psoriatic Arthritis
Authors: Alessa Dana , Levin Adriane A. , Gottlieb Alice B.
Published: April 2018

Objectives

The purpose of this study was to review evidence for the efficacy and safety of cyclosporine therapy in patients with psoriatic arthritis.

Methods

We performed a systematic literature review of available evidence using the electronic database PubMed.

Results

The available evidence suggests that cyclosporine may be an effective third-line treatment for psoriatic arthritis. However, its well-established side effect profile limits long-term use.

Conclusion

Cyclosporine may be an effective treatment option for psoriatic arthritis, but large randomized, placebo-controlled clinical trials with adequate sample sizes are needed to assess its impact on symptomatic control, inhibition of radiological disease progression, prevention of disability, and improvement of quality of life.
Review of Curcumin, Indigo Naturalis, and Aloe Vera in Psoriasis Treatment
Authors: Chaudhari Soham , Leon Argentina , Thakur Amrit , Koo John
Published: April 2018

Background

Psoriasis is an inflammatory skin condition characterized by hyperproliferating keratinocytes, aberrant epidermal differentiation, and infiltrating inflammatory cells. Traditional herbal medicine has been used extensively to treat psoriasis with promising clinical results. Due to the vast number of herbal preparations used all over the world, we have focused on curcumin, indigo naturalis (IN), and aloe vera (AV) because they are the most commonly reported herbal therapeutics.

Objective

This review illustrates the beneficial effects of multiple herbal medications as a therapeutic alternative in the treatment of psoriasis.

Methods

A thorough literature search of the PubMed database was conducted to identify psoriasis studies utilizing these three herbs as therapeutics.

Results

Curcumin has been demonstrated to be a TNFα blocker. IN has been effective in treating plaque and nail psoriasis. AV-treated psoriasis also has shown clinical improvement.

Conclusion

Further studies are needed to back up these claims before these formulations can be accepted into the current treatment regimens.
Immune Modulation with Combined Vitamin D Analogs and Corticosteroids in Psoriasis
Authors: Gottlieb Alice B.
Published: April 2018

Psoriasis is characterized by excessive growth and aberrant differentiation of keratinocytes and by dysregulation of immune cells. Topical vitamin D analogs and corticosteroids are commonly used for the treatment of mild-to-moderate plaque psoriasis. The effects of corticosteroids are predominantly anti-inflammatory and immunosuppressive, while those of vitamin D analogs have long been considered antiproliferative. Recent evidence suggests an independent role of vitamin D analogs and corticosteroids in cytokine modulation, an important factor in treatment efficacy. In vitro and in vivo studies show that the combination of a vitamin D analog and a corticosteroid produces effects on T-cell subsets that are involved in psoriatic skin inflammation. Based on the respective mechanisms of action of vitamin D analogs and corticosteroids, there is a biologic rationale for the enhanced clinical effect observed with the combination therapy. This article reviews current understanding of the pathogenesis of psoriasis and recent evidence for immunomodulatory mechanisms of vitamin D analogs and corticosteroids.
Efficacy of the hypoxia‐activated prodrug evofosfamide (TH‐302) in nasopharyngeal carcinoma in vitro and in vivo
Authors: Huang Yan , Tian Ying , Zhao Yuanyuan , Xue Cong , Zhan Jianhua , Liu Lin , He Xiaobo , Zhang Li
Published: May 2018

Background

Tumor hypoxia is considered an important factor in metastasis and disease relapse. Evofosfamide is a hypoxia‐activated prodrug that selectively targets the hypoxic regions of solid tumors. As hypoxia‐inducible factor‐1α (HIF‐1α) is overexpressed in nasopharyngeal carcinoma (NPC) tissues, we performed the present study to evaluate the efficacy profile of evofosfamide in NPC.

Methods

We evaluated the efficacy of evofosfamide as a single agent or combined with cisplatin (DDP) in the NPC cell lines CNE‐2, HONE‐1 and HNE‐1, and in nude mouse xenograft tumor models.

Results

Evofosfamide exhibited hypoxia‐selective cytotoxicity in NPC cell lines, with 50% inhibition concentration (IC50) values of 8.33 ± 0.75, 7.62 ± 0.67, and 0.31 ± 0.07 μmol/L under hypoxia in CNE‐2, HONE‐1 and HNE‐1 cells, respectively. The sensitization ranged from ninefold to greater than 300‐fold under hypoxia compared with normoxia controls. The combination of evofosfamide with DDP had a synergistic effect on cytotoxicity in the NPC cell lines by combination index values assessment. Cell cycle G2 phase was arrested after treated with 0.05 μmol/L evofosfamide under hypoxia. Histone H2AX phosphorylation (γH2AX) (a marker of DNA damage) expression increased while HIF‐1α expression suppressed after evofosfamide treatment under hypoxic conditions. In the HNE‐1 NPC xenograft models, evofosfamide exhibited antitumor activity both as a single agent and combined with DDP. Hypoxic regions in xenograft tissue were reduced after both evofosfamide monotherapy and combined therapy with DDP.

Conclusions

Our results present preclinical evidence for targeting the selective hypoxic portion of NPC by evofosfamide as a single agent and combined with DDP and provide rationale for the potential clinical application of evofosfamide for the treatment of nasopharyngeal carcinoma.
A simple relationship between thermal conductivity and seismic interval velocity
Authors: Duffaut Kenneth , Hokstad Ketil , Kyrkjeb⊘ Rune , Wiik Torgeir
Published: April 2018

The subsurface temperature is of major interest for assessment of the petroleum prospectivity of a sedimentary basin. A key parameter in modeling the thermal structure of the subsurface is thermal conductivity. The information about lateral variation of this parameter is usually sparse. We propose a simple linear relationship between thermal conductivity and seismic velocity for clastic sedimentary rocks. The coefficient of proportionality depends on the clay fraction. This implies that thermal conductivity and seismic velocity have a similar sensitivity to porosity. Both thermal conductivity and seismic velocity increase with decreasing porosity. For a given porosity, quartz-rich rocks have higher thermal conductivity than clay-rich rocks, which is in agreement with experimental observations. Whenever seismic velocity models are available from seismic surveying, the proposed thermal conductivity-velocity relationship can be used to obtain laterally varying 2D and 3D thermal conductivity models for use in basin modeling.
Financial Impact of Complex Cancer Surgery in India: A Study of Pancreatic Cancer
Authors: Basavaiah Guruchanna , Rent Priyanka D. , Rent Eugene G. , Sullivan Richard , Towne Margaret , Bak Marieke , Sirohi Bhawna , Goel Mahesh , Shrikhande Shailesh V.
Published: May 2018

Purpose

The rapidly increasing burden of cancer in India has profound impacts on health care costs for patients and their families. High out-of-pocket (OOP) expenditure, lack of insurance, and low government expenditure create a vicious cycle, leading to household impoverishment. Complex cancer surgery is now increasingly important for emerging countries; however, little is understood about the macro- and microeconomics of these procedures. After the Lancet Oncology Commission on Global Cancer Surgery, we evaluated the OOP expenditure for patients undergoing pancreatico-duodenectomy (PD) at a government tertiary cancer center in India.

Methods

Prospective data from 98 patients who underwent PD between January 2014 and June 2015 were collected and analyzed. The time frame for consideration of expenses, including all preoperative investigations, was from the first hospital visit to the day of discharge. Catastrophic expenditure was calculated by assessing the percentage of households in which OOP health payments exceeded 10% of the total household income.

Results

The mean expenditure for PD by patients was Rs.295,679.57 (US$74,420, purchasing power parity corrected). This amount was significantly higher among those admitted to a private ward and those with complications. Only 29.6% of the patients had insurance coverage. A total of 76.5% of the sample incurred catastrophic expenditure, and 38% of those with insurance underwent financial catastrophe compared with 93% of those without insurance. The percentage of patients facing catastrophic impact was highest among those in semiprivate wards, at 86.7%, followed by those in public and private wards.

Conclusion

The cost of PD is high and is often unaffordable for a majority of India’s population. A review of insurance coverage policies for better coverage must be considered.
Proliferation-independent role of NF2 (merlin) in limiting biliary morphogenesis
Authors: Benhamouche-Trouillet Samira , O'Loughlin Evan , Liu Ching-Hui , Polacheck William , Fitamant Julien , McKee Mary , El-Bardeesy Nabeel , Chen Christopher S. , McClatchey Andrea I.
Published: April 2018

The architecture of individual cells and cell collectives enables functional specification, a prominent example being the formation of epithelial tubes that transport fluid or gas in many organs. The intrahepatic bile ducts (IHBDs) form a tubular network within the liver parenchyma that transports bile to the intestine. Aberrant biliary ‘neoductulogenesis’ is also a feature of several liver pathologies including tumorigenesis. However, the mechanism of biliary tube morphogenesis in development or disease is not known. Elimination of the neurofibromatosis type 2 protein (NF2; also known as merlin or neurofibromin 2) causes hepatomegaly due to massive biliary neoductulogenesis in the mouse liver. We show that this phenotype reflects unlimited biliary morphogenesis rather than proliferative expansion. Our studies suggest that NF2 normally limits biliary morphogenesis by coordinating lumen expansion and cell architecture. This work provides fundamental insight into how biliary fate and tubulogenesis are coordinated during development and will guide analyses of disease-associated and experimentally induced biliary pathologies.
Assembly of the small ribosomal subunit in yeast: mechanism and regulation
Authors: Chaker-Margot Malik
Published: April 2018

The eukaryotic ribosome is made of four intricately folded ribosomal RNAs and 79 proteins. During rapid growth, yeast cells produce an incredible 2000 ribosomes every minute. Ribosome assembly involves more than 200 trans-acting factors, intervening from the transcription of the preribosomal RNA in the nucleolus to late maturation events in the cytoplasm. The biogenesis of the small ribosomal subunit, or 40S, is especially intricate, requiring more than four times the mass of the small subunit in assembly factors for its full maturation. Recent studies have provided new insights into the complex assembly of the 40S subunit. These data from cryo-electron microscopy, X-ray crystallography, and other biochemical and molecular biology methods, have elucidated the role of many factors required in small subunit maturation. Mechanisms of the regulation of ribosome assembly have also emerged from this body of work. This review aims to integrate these new results into an updated view of small subunit biogenesis and its regulation, in yeast, from transcription to the formation of the mature small subunit.
Globalização, Regionalização, Reforma do Estado e da Constituição
Authors: Moreira Neto Diogo de Figueiredo
Published: May 2018

1. Globalização - 2. Regionalização - 3. Reforma do Estado - 4. A legislação - 5. A administração - 6. A jurisdição - 7. Reforma da Constituição - 8. Conclusões.
Respeito aos precedentes judiciais iterativos pela Administração Pública
Authors: Freitas Juares
Published: May 2018

1. Introdução. 2. Da conveniência de a Administração Pública acatar as decisões judiciais iterativas e pacificadas. 3. Dos limites hermenêuticos aos "precedentes vinculantes" em relação ao próprio Poder Judiciário: a necessária preservação do controle difuso. 4. Conclusões.
A nova organização dos serviços na Lei Geral de Telecomunicações
Authors: Celli Júnior Umberto
Published: May 2018

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A disponibilidade remunerada dos servidores públicos à luz da Constituição de 1988
Authors: Oliveira Gustavo Henrique Justino de
Published: May 2018

1. Considerações iniciais. 2. A disponibilidade no direito positivo brasileiro. 2.1. O histórico constitucional do instituto. 2.2. A disponibilidade na Constituição de 1988. 2.3. O tratamento na legislação federal. 3. A natureza jurídica da disponibilidade. 4. Disponibilidade e estabilidade. 4.1. Disponibilidade e vitaliciedade. 5. Extinção e declaração de desnecessidade de cargos públicos. 6. O afastamento do servidor em disponibilidade. 7. A remuneração na disponibilidade. 7.1. A posição do Supremo Tribunal Federal. 7.2. As vantagens excluídas dos vencimentos de disponibilidade. 8. A figura do aproveitamento. 9. Disponibilidade e Reforma Administrativa. 10. Conclusões.
Função administrativa, estabilidade e princípio da neutralidade: alguns apontamentos sobre a reforma administrativa
Authors: Soares Fabiana de Menezes
Published: May 2018

1. Natureza Jurídica da Função Pública. Princípios Informadores. Conseqüências sobre a atuação do agente público, o regime Jurídico da função pública. 2. Princípio da Neutralidade. Administração Eficiente e Estado de Direito. Notas de Direito Comparado 3. A boa execução da função pública. O princípio da profissionalização. A Reforma Administrativa em face da Estabilidade Relativa. O Apeifeiçoamento e a formação do Funcionário Público. Bibliografia.
Emenda Constitucional, Leis, Lei Complementar, Razões de veto, Decretos e Medidas Provisórias (1998)
Authors: Desconhecido Desconhecido
Published: May 2018

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Do poder Judiciário : como torná-lo mais ágil e dinâmico : efeito vinculante e outros temas
Authors: Velloso Carlos Mário da Silva
Published: May 2018

1. A lentidão da Justiça. seu mal maior. 2. Causas da lentidão: 2.1. A explosão de processos; 2.2. O número deficiente de juízes de 1º grau; 2.3. Forma inadequada de recrutamento dos juízes; 2.4. O desaparelhamento do apoio administrativo no 1º grau; 2.5. As leis processuais: formalismo excessivo e o sistema irracional de recursos. 3. Soluções propostas: 3.1. Eficácia erga omnes e efeito vinculante; 3.2. As leis processuais e o sistema de recursos; 3.3 O recurso constitucional; 3.4. A argüição de relevância; 3.5. Efeito ex tune e ex nunc das decisões do S. T.F. no controle de constitucionalidade; 3.6. O fetichismo da jurisprudência uniforme; 3.7. A valorização do juiz de 1º grau; 3.8. Juizados especiais de pequenas causas; 3.9. A justiça de 1º grau: aparelhamento. 4. O controle de qualidade do Judiciário; 4.1. Escolas de formação e aperfeiçoamento da magistratura; 4.2. Conselho Nacional da Magistratura; 4.3. O Corregedor-Geral ou o "investigador da Justiça". 5. Conclusão..
A democracia e suas dificuldades contemporâneas
Authors: Mello Celso Antônio Bandeira de
Published: May 2018

I. Democracia formal e democracia substancial. II. A crise dos instrumentos clássicos da democracia. III. Tentativas de resposta à crise da democracia. IV. Insuficiência dos meios concebidos para salvaguarda dos ideais democráticos. V. Possível agravamento da crise da democracia. VI. Globalização e neoliberalismo: novos obstáculos à democracia.
A dignidade da pessoa humana com valor supremo da democracia
Authors: Silva José Afonso da
Published: May 2018

1. Fundamento constitucional - 2. Pessoa humana - 3. Dignidade - 4. Proteção constitucional da dignidade humana - 5. Natureza da dignidade tutelada - 6. Conclusão.
Empresa, Ordem Econômica e Constituição
Authors: Justen Filho Marçal
Published: May 2018

I. Colocação do Problema. II. Eficiência econômica e produção empresarial. III. O conceito de empresa (segundo a visão jurídica tradicional). III.1. A "descoberta" da "empresa". III.2. A "empresa" e sua configuração jurídica. a) Empresa como conceito jurídico e como objeto cultural. b) Empresa como fenômeno complexo. c) Complexidade especial do fenômeno da empresa. d) A multiplicidade de facetas do conceito de empresa (visão de ASQUINI). e) O cunho ideológico do conceito de empresa (na visão tradicional). f) Síntese acerca da questão. IV. A Empresa no Direito Brasileiro. IV. I. O Código Comercial de 1850 e a evolução legislativa. IV.2. As conseqüências da omissão legislativa infraconstitucional. IV. 3. A disciplina constitucional da atividade empresarial. IV.4. Atividade empresarial e princípio da proporcionalidade. V. A crise estatal e o neoliberalismo. V.I. A crise estatal. V.2. A revolução ideológica. V.3. O mercado mundial. V.4. Síntese. VI. O neoliberalismo e a relevância da empresa. VII. As modificações constitucionais. VII.I. As reformas constitucionais (Emendas nº 5 a 9). VII.2. A extensão dos efeitos da reforma constitucional. VII.3. A ampliação da margem de exploração empresarial. VII.4. A modificação da estrutura tributária. VII.5. A abertura do mercado nacional. VIII. A reafirmação da função constitucional da empresa. IX. Direito e Atividade Empresarial. IX. I. Limites intransponíveis à atuação empresarial. IX. 2. Funcionalização da empresa. IX.3. Neoliberalismo e Estado Democrático de Direito. IX.4. Fortalecimento empresarial e livre concorrência.IX.5. Pragmatismo e Soberania. IX. 6. Pragmatismo e Ética. X. Conclusão.
Considerações sobre BOT - Project Finance e suas aplicações em concessões de serviços públicos
Authors: Mendes Luiza Rangel de
Published: May 2018

I - INTRODUÇÃO - Aspectos gerais de project finance; 2 - Conceito de BOT - Project Finance; 3 - BOT (Build-Operate-Transfer) e BOO (Build-Own-Operate); 4 - Estrutura de BOT; 5 - Das Concessões de Serviços Públicos; 6 - Da Concessão de Serviço Público em Sentido Estrito; 7 - Da Concessão Precedida de Obra Pública; 8 - Da Subconcessão; 9 - Da Compatibilidade da Estrutura BOT - Project Finance com o Regime das Concessões de Serviços Públicos; 10 - Experiência Nacional e Internacional de Financiamento de Estrutura através de Projetos BOT; (a) Experiência Nacional; (b) Experiência Internacional - Cancun. Puerta Vallarta. Austrália. China; II - Conclusões.
Contratos de franquia - Correios e telégrafos - Tribunal de Contas
Authors: Macedo José Antônio Bandeira de
Published: May 2018

- Contrato de franquia celebrado pela Empresa Brasileira de Correios e Telégrafos é contrato mercantil. não importando concessão ou subconcessão de serviço público.- Incompetência do Tribunal de Contas para exame de contas relativas a contrato de franquia.
Intervenção do domínio econômico - Sociedade de economia mista - Abuso do poder econômico
Authors: Barroso Luís Roberto
Published: May 2018

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Lei municipal - Concessão de uso - Direito de passagem
Authors: Mukai Toshio
Published: May 2018

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Licitação - Capacidade técnico-operacional - Exigibilidade
Authors: Dallari Adilson Abreu
Published: May 2018

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Emenda Constitucional, Leis, Razões de veto, Medida provisória e Decreto (1998)
Authors: Desconhecido Desconhecido
Published: May 2018

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Repercussões da Emenda Constitucional nº 19 sobre o regime jurídico das licitações
Authors: Pereira Junior Jessé Torres
Published: May 2018

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Da falta de razoabilidade do Poder Legiferante
Authors: Mattos Mauro Roberto Gomes de
Published: May 2018

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Reforma Constitucional e direito adquirido
Authors: Silva José Afonso da
Published: May 2018

I. Introdução à lei no tempo. I - ESTABILIDADE DOS DIREITOS SUBJETIVOS: 2. Segurança das relações jurídicas e lei no tempo. 3. Direito adquirido. 4. Ato jurídico perfeito e direito adquirido. 5. Coisa julgada. II- NORMA CONSTITUCIONAL E DIREITO ADQUIRIDO. 6. Questão de ordem. 7. Poder constituinte originário e direito adquirido. 8. Poder de reforma e direito adquirido. 9. Norma de garantia e direito garantido. 10. Conclusão.
Agências Reguladoras
Authors: Azevedo Eurico de Andrade
Published: May 2018

1. Introdução; 2. Autarquias sob regime especial; 3. Agências Reguladoras Federais; 4. Agência Reguladora dos Serviços de Energia do Estado de São Paulo; 5. Conclusões.
Suspensão de segurança - Grave lesão - Prova inequívoca
Authors: Mello Celso Antônio Bandeira de
Published: May 2018

- A suspensão de segurança exige prova inequívoca de grave lesão à ordem e à economia pública.
Servidor público - Pagamento indevido - Reposição
Authors: Fraga Mirtô
Published: May 2018

- Quantias recebidas de boa fé em virtude de errônea interpretação da lei e posterior mudança de critério não precisam ser propostas.- Pagamento feito mediante liminar posteriormente cassada configura pagamento indevido sujeito a reposição.
Contrato administrativo - Subcontratação - Cessão
Authors: Macedo José Antônio Barreto de
Published: May 2018

- A subcontratação não produz relação direta entre a Administração e o subcontratado. Na cessão total ou parcial do contrato o cessionário assume a situação de contratante, investindo-se no status contratual em substituição ao cedente.
Empresa estatal - Atividade-fim - Dispensa de licitação
Authors: Saraiva Iram
Published: May 2018

- As atividades-fins das empresas estatais regem-se pelo direito privado e não estão sujeitas à obrigatoriedade da licitação, que apenas é exigível para suas atividades-meio.
Patente de invenção - Acordo Internacional - Vigência
Authors: Borja Celio
Published: May 2018

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Professor - Ascensão - Concurso público
Authors: Batista Wagner Natal
Published: May 2018

- Professor. Estado de Santa Catarina. Acesso mediante comprovação de nova habilitação profissional. Estatuto do magistério público: Lei estadual n. 6.844/86. Incompatibilidade com o art. 37, II. da Constituição Federal. - O sistema constitucional. ressalvados os cargos em comissão, exige o concurso público de provas ou de provas e títulos para a investidura em cargo ou emprego público.- A ascensão, que constitui forma de ingresso em carreira diversa daquela para a qual o servidor ingressou no serviço público. foi banida das formas de investidura admitidas pela Constituição. Jurisprudência do Supremo Tribunal Federal.- Ao permitir o ingresso por acesso de professores ocupantes de carreira inferior para outra mais elevada, sem prévio concurso público, a lei catarinense mostra-se incompatível com o art. 37, II, da Carta Federal".- Recurso extraordinário conhecido e provido.
Cargo público - Concurso - Ascensão
Authors: Batista Wagner Natal
Published: May 2018

- Provimento de cargo público. Ascensão. 1 - Não é suscetível de provimento por ascensão o cargo que for objeto de provimento por concurso público. 3 - Concurso de acesso que no sistema da lei catarinense configura ascensão funcional. 4 - Conceito de carreira. Acesso de classe a classe dentro da mesma categoria funcional. 5 - Se para prover cargo inicial de uma categoria funcional prevê-se concurso público, essa categoria funcional não pode vir a ter seus cargos preenchidos, mediante ascensão funcional, com concurso de acesso, desde a última classe de outra categoria funcional inferior. 6 - Recurso extraordinário conhecido e provido.
Seguridade social - Desconto em benefício - Carta rogatória
Authors: Mello Celso Antônio Bandeira de
Published: May 2018

- Não cabe exequatur em Carta Rogatória para desconto em benefício de seguridade social.
Previdência social - Benefícios - Revisão
Authors: Sanches Sydney
Published: May 2018

Supremo Tribunal Federal         Direitos autorais reservados a Editora Renovar. Consulte este artigo na Biblioteca.
Medida Provisória, Leis e Decretos (1998)
Authors: Desconhecido Desconhecido
Published: May 2018

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Cardiac Troponins in Low‐Risk Pulmonary Embolism Patients: A Systematic Review and Meta‐Analysis
Authors: Darwish Omar S. , Mahayni Abdullah , Patel Mukti , Amin Alpesh
Published: April 2018

BACKGROUND

Patients with low‐risk pulmonary embolism (PE) should be considered as per current scoring systems for ambulatory treatment. However, there is uncertainty whether patients with low scores and positive troponins should require hospitalization.

METHODS

We searched MEDLINE, SCOPUS, and Cochrane Library databases from inception to December 2016 and collected longitudinal studies that evaluated the prognostic value of troponins in patients with low‐risk PE. The primary outcome measure was 30‐day all‐cause mortality. We calculated odds ratio (OR), likelihood ratios (LRs), and 95% confidence intervals (CI) by using random‐effects models.

RESULTS

The literature search identified 117 candidate articles, of which 16 met the criteria for review. Based on pulmonary embolism severity index (PESI) or simplified PESI score, 1.2% was the all‐cause mortality rate across 2,662 participants identified as low‐risk. A positive troponin status in patients with low‐risk PE was associated with an increased risk of 30‐day all‐cause mortality (odds ratio [OR]: 4.79; 95% confidence interval [CI]: 1.11 to 20.68). The pooled likelihood ratios (LRs) for all‐cause mortality were positive LR 2.04 (95% CI, 1.53 to 2.72) and negative LR 0.072 (95% CI, 0.37 to 1.40).

CONCLUSION

The use of positive troponin status as a predictor of increased mortality in low‐risk PE patients exhibited relatively poor performance given the crossed negative LR CI (1.0) and modest positive LR. Larger prospective trials must be conducted to elucidate if patients with low‐risk PE and positive troponin status can avoid hospitalization. Journal of Hospital Medicine 2018;13:706‐712. Published online first April 25, 2018. © 2018 Society of Hospital Medicine
Efectos de método en el Inventario de Depresión Estado-Rasgo (ider): un análisis sem
Authors: Dominguez Lara Sergio Alexis , Merino Soto César
Published: April 2018

El objetivo del presente estudio instrumental fue determinar si existe un efecto del método asociado a la formulación de ítems invertidos que conforman la subescala eutimia del Inventario de Depresión Estado-Rasgo (ider). Se contó con una muestra intencional de 357 estudiantes universitarios, de los cuales 147 fueron varones y 210 mujeres, cuyas edades estuvieron entre 16 y 44 años (media: 20,21). Se evaluaron cuatro modelos mediante análisis factorial confirmatorio: un modelo de dos factores correlacionados, eutimia y distimia; un modelo que agrupa todos los ítems en un solo factor, con un factor de método independiente asociado a los ítems del factor eutimia (ítems invertidos); un modelo que evalúa el ajuste de las secciones rasgo y estado simultáneamente, manteniendo el modelo de dos factores oblicuos, lo cual sirvió como línea base para comparar el cuarto modelo, que incluye el factor del método común a las secciones estado y rasgo. Los modelos dos y cuatro presentaron el mejor ajuste entre los cuatro propuestos, aunque sin ser definitivamente mejores que los modelos de factores oblicuos. Ante ello, no se demostró la presencia determinante de un factor de método asociado a los ítems invertidos de la escala eutimia. Fueron discutidas las implicancias de los resultados.
Taking Trade-offs Seriously: Examining the Contextually Contingent Relationship Between Social Outreach Intensity and Financial Sustainability in Global Microfinance
Authors: Wry Tyler , Zhao Eric Yanfei
Published: April 2018

A key insight from research on hybrid organizing is that the joint pursuit of competing goals exposes an enterprise to potentially problematic tensions and trade-offs. Yet while studies have examined the former, the actual trade-offs that these organizations face—and how these might vary among enterprises and contexts—has been largely overlooked. Focusing on social enterprise, we address these gaps by (1) developing a framework that can be used to predict the compatibility of social outreach and financial sustainability for different types of enterprises and (2) arguing that the acuteness of trade-offs will vary based on the cultural roots of the issue an enterprise addresses, the market conditions where it operates, and the quality of its management. We test our arguments by studying 2,037 microfinance organizations in 115 nations between 1995 and 2013. Results support our predictions. Social–financial trade-offs are amplified when a social issue is intertwined with deep-seated cultural problems, such as discrimination, and when an enterprise operates in a weak institutional environment. Intensive social outreach becomes sustainable, however, when cultural barriers to outreach are low, market-supporting institutions are strong, and an enterprise is professionally managed. Our study thus shows that social–financial trade-offs are contingent and that the promise of sustainable social outreach varies widely across contexts.

The e-companion is available at https://doi.org/10.1287/orsc.2017.1188 .
Optimization of Pectinase Production by Aspergillus Oryzae RR 103
Authors: Ketipally Ravi. , Ram M.Raghu
Published: April 2018

The purpose of this investigation is to isolate and Exploit diversified microorganisms from mangrove habitat and their commercial utilization in industrial sector. Pectinases are enzymes having a broad Industrial and commercial applications. Polygalacturonase produced by microorganisms which breakdown pectin, present in plant material to simple chemical substances. The enzymatic breakdown of α-1, 4-glycosidic linkages in polygalacturonic acid is catalysed by Polygalacturonic acid, releasing D-galacturonate which is a simple chemical substance. The production of Polygalacturonase by Aspergillus oryzae RR103 was enhanced by optimization of different nutritional parameters. Highest polygalacturonase activity was observed at 192h at 35°C. Optimum pH for the production of enhanced Polygalacturonic acid was at pH 6.0. The carbon and nitrogen sources which gave enhanced enzyme activity were Cellulose and Malt extract respectively. Highest enzyme specificity was recorded when the substrate used was citrus pectin. Polygalacturonase from Aspergillus oryzae RR 103 is suitable for industrial scale production as it has high productivity.
Performance of Pulses in Gujarat: A District level Assessment
Authors: Sudhakarrao More Sachin , Singh Narendra , Bhatt B. K.
Published: April 2018

A research was conducted to assess the performance of pulses in one of the most important agriculture states of India. Performance of pulse crops was judged on two important parameters i.e. growth and instability. Compound growth rate was estimated by fitting non linear model to the area, production and productivity data for the period from 1970-71 to 2011-12. The fitted model was analyzed using Marquardt algorithm. Instability was assessed by employing Cuddy-Della Valle instability index. The results show that, the production of pulses increased in the state during the entire study period. The increase in pulse crops in the state was due to area expansion coupled with marginal improvement in yield up to the year 1990 after that, increase in production was mainly from improvement in the yield of pulse crops as area was stagnated. Area under pulse crops increased consistently up to year 1990 afterwards it was stagnated. Consistent improvement in the yield of pulses was a notable feature which shows that improved technology has payoff in the state. High growth in area, production and yield of pulse crops was associated with high level of instability during first sub period. Yield variability in pulse crops was relatively higher than area variations which clearly indicated that yield instability was a major source of variation in the production of pulses. Therefore attempt should be made to stabilize the yield level in pulse crops.
Self-care for older people with psoriasis
Authors: Onselen Julie Van
Published: April 2018

Psoriasis affects 1.5% of the UK population and due to the ageing population it is more common in older people. The incidence of type II psoriasis peaks in patients between 57 and 62 years of age, and has different genetic markers. Chronic plaque psoriasis can be challenging for older people as the majority are treated in primary care and expected to self-manage. Community nurses can support older people with psoriasis and their families in understanding current evidence based psoriasis management, and finding solutions to these challenges.
Motivating your students : Part 2
Authors: Bromley Mat
Published: April 2018

How can we motivate the pupils in our classrooms and schools to want to learn? Mat Bromley concludes his two-part article on motivation by looking at what schools and teachers can do to inspire students…
Money and Totality: Another Round of Debate on Value Formation and Transformation
Authors: David Laibman
Published: April 2018

Fred Moseley's Money and Totality (2016) presents the author's “macro-monetary interpretation” of Marx's value theory, with particular reference to the transformation of value into price of production in Capital, Volume III. This theory, while trying to be faithful to Marx's texts, accomplishes this by means of a logically indefensible claim, which, if it came to be seen as representing Marx's work as such, would contribute to sidelining and disconfirming the Marxist tradition. Review of the long-standing “transformation problem” debate, in the light of Moseley's contribution, in non-technical terms, suggests that the way forward is to avoid text-based orthodox defenses of Marx in favor of re-working his core insights, building on the accomplishments of Marxist theory in the 20th century, and using the tools and methods of modern economic theory and social science wherever possible.
Spectres of domesticity: Carly Holmes’s ‘Piece by Piece’ and Tessa Hadley’s ‘Bad Dreams’
Authors: Mieszkowski Sylvia
Published: April 2018

This article offers interpretations of two contemporary gothic short stories, which position themselves in the literary tradition of the domestic uncanny. Both Carly Holmes’s ‘Piece by Piece’ and Tessa Hadley’s ‘Bad Dreams’ install repetition (doubling, seriality, narrative double loop) as a structural device and link it to the motif of work, to create spectres that haunt their respective domestic spaces. Whilst the former piece of short fiction does so by activating some of the classical topoi of the haunted house tale, with a twist, the latter showcases healing as well as destructive effects that work produces, both in its performance and its undoing. Using Freud’s definition of the uncanny as their backdrop, the readings of both stories draw on some of Jacques Derrida’s theorizations in Spectres of Marx and the interview ‘Spectographies’: of the spectre as a figuration of deconstructive in-between-ness; on the spectre’s visor effect of being in the gaze of that which itself cannot be seen and of work as a trace. As its main thesis, this piece proposes that work, in Holmes’s ‘Piece by Piece’ and Hadley’s ‘Bad Dreams’, is not only a spectral activity in itself but also creates haunting presences-in-absence.
Ghost texts in Alice Munro’s stories
Authors: Bigot Corinne
Published: April 2018

This article aims to apply the concepts of ‘ghost scenarios’ and ‘ghost texts’ to Alice Munro’s short stories, a concept that Michel Charles introduced in the context of reader-response theory. Using ‘Gravel’, from Munro’s 2012 collection, as an exemplar, the article focuses on the role intratextuality plays in Munro’s oeuvre and its effect on readers. I propose to see previous stories that hover as subtexts as ‘ghost scenarios’ that haunt the Canadian short story writer’s fiction and induce ‘erratic readings’, in particular in stories where mysterious deaths occur. Ghost texts also increase uncertainty and induce niggling doubt, reinforcing the overall haunting effect that Munro’s stories often convey.
Coincident origins: Dress and civilization in the Garden of Eden
Authors: Matheson Linda Florence
Published: May 2018

This study posits that the postmodern practice of uniting dress and mythology has its roots in the Creation Stories of the Judeo/Christian Bible, perhaps the greatest myth ever told. Here the practice of dress finds its genesis in Genesis at the same time as the civilization project. Using the work of Jacques Lacan, Gregory Stone and Georg Simmel, the article questions the significance of this coincidence by tracking the responses that the initial state of nakedness calls forth, and the effect of these responses on the development of self and society in tandem with the development of the practice of dress.
Re-evaluating Oscar Hammerstein’s 1930s: His popular and critical success from Viennese Nights (1930) to The Last Time I Saw Paris (1940)
Authors: Garber Michael
Published: May 2018

Between 1930 and 1942, Oscar Hammerstein II was not the failure that he and others claimed. In print and interviews, Hammerstein represented this as a period when his works were rejected by audiences and critics, and biographers have followed his lead. Countering that subject-imposed viewpoint, this article examines newly digitized primary sources, audience reception and a more recent generation of criticism to greatly modify previous assessments. This study tracks 25 songs that attained prominence and explores Hammerstein’s neglected contributions to popular musicals such as May Wine (1935), The Great Waltz (1938, surprisingly well-known in China) and Hellzapoppin (1938).
Correlação da energia de fratura com parâmetros reológicos de ligantes e mástiques asfálticos
Authors: Bardini Vivian Silveira dos Santos , Klinsky Luis Miguel Gutiérrez , Fernandes Júnior José Leomar , Roque Reynaldo
Published: April 2018

A energia de fratura é uma propriedade relacionada com a contribuição de ligantes asfálticos à resistência à fadiga de misturas asfálticas e, portanto, tem grande influência no comportamento mecânico de pavimentos flexíveis, particularmente no desenvolvimento e propagação de trincas. Esta pesquisa tem o objetivo de contribuir para um melhor entendimento dos efeitos do fíler mineral e do ligante asfáltico na relação da energia de fratura com os parâmetros reológicos de ligantes e mástiques asfálticos, em temperaturas intermediárias. Para a determinação da energia de fratura foi realizado o ensaio Binder Fracture Energy (BFE), desenvolvido na Universidade da Flórida, em função do tipo e teor do fíler mineral e do ligante asfáltico. Os resultados mostram que a energia de fratura pode ser relacionada com o módulo de cisalhamento dinâmico (G*) e com o ângulo de fase (δ), obtidos em ensaios no reômetro de cisalhamento dinâmico (DSR), com a rigidez [S(t)] e com a taxa de relaxação [m(t)], obtidos em ensaios de fluência de viga à flexão (BBR). No entanto, todas as correlações são tênues, reforçando a hipótese de que uma inferência mais adequada sobre o desempenho à fadiga de uma mistura asfáltica pode ser obtida quando a energia de fratura é utilizada juntamente com propriedades fundamentais tradicionais.
Estudo de desempenho à fadiga de base cimentada tipo BGTC na BR-101/SE
Authors: Albuquerque Fernando Silva , Nascimento Rodrigo Da Silva
Published: April 2018

O ganho de rigidez ao pavimento fez com que o uso de camada de brita graduada tratada com cimento (BGTC) passasse a ser frequente em projetos de pavimentos novos no Brasil. Seu uso em vias de grande frequência de carregamento se apresenta como uma solução viável, podendo ser empregada tanto em base, quanto em sub-base. Possivelmente, a grande desvantagem do uso da BGTC esteja relacionada ao seu processo de ruptura quase-frágil por fadiga, o que leva algumas vezes ao dano acelerado à estrutura do pavimento. Nesta pesquisa, foi feita a determinação da vida de fadiga em laboratório e definido um fator laboratório-campo, extraído do acompanhamento do desempenho estrutural de trecho monitorado na BR-101/SE, pela aplicação do princípio do dano acumulado da Hipótese de Miner. Também foi acompanhada e determinada a evolução do dano causado pela ação do tráfego, bem como a sua influência na redução da rigidez deste material ao longo do tempo, por um período de trinta e seis meses, o que permitiu ajustar um modelo que relaciona a rigidez da camada ao dano acumulado.
Causes and effects of water pollution in the Soniwein Community, Central Monrovia, Liberia (March to May 2017)
Authors: CHEA Sampson K. P. , Andrew P. DEAN
Published: April 2018

Water pollution can be defined in many ways. Usually, it means one or more substances have built up in water to such an extent that they cause problems for animals or people. The objectives of this study were to determine the causes and effects of Water pollution in Soniwein Community and to determine whether the cases of water borne diseases can be attributed to unsafe and contaminated water in Soniwein Community as well as to come up with interventional strategies by which water pollution can be mitigated in the Soniwein Community. This research employed the cross sectional survey design. Field interviews were done by close-ended questionnaires, including health workers at Soniwein Community Clinic. Water samples were randomly collected and microbiological and chemical tests were conducted at the National Standards Lab to determined contamination by microbes and physical quality of the water respectively Samples were randomly collected from the Soniwein community and tested The microbiological test reveals a rejection in total viable count for Well 1, [2], [3] & [4], N/A in Yeasts & Mold, for Well 1, 2, 3, 4, detection of E. Coli in Well 1, 2, 3 & 4. The results of the chemical test reveals the iron content of Well [1-3] to be in acceptable range while that of well 4 was out of acceptable range; the chloride content of Well [1-4] were all in acceptable range; the pH values for Well 1, 2, 3 & 4 were all in normal rang; Well 1, 2, & 3 were all in acceptable turbidity range while that of well 4 showed a deviant. Water pollution in the Soniwein Community is caused by several factors such poor sanitation, improper disposal of domestic wastes and the effects lead to water- borne diseases such as Typhoid, Diarrhea and dysentery, and infants between the ages of 0-2 years are mostly affected.
Study on microstructural and mechanical properties of dissimilar joint of laser beam welded Inconel 625 and SS 316
Authors: GMishra Akshansh , Dixit Devarrishi , Sharma Abhishek Kumar
Published: May 2018

This paper investigates the microstructure and properties of deep penetrated laser welded dissimilar joints of Inconel
625 nickel based alloys and 316 Stainless Steel. Evaluation of weld microstructures through optical microscopy,
Brinell Hardness test, Tensile test at room temperature and stress rupture properties were done. The Experimental
results showed that the microstructure of the weld zone near the fusion line in Inconel 625 were columnar dendrites,
whereas that near the fusion line in SS 316 were mainly cellular. The tensile strength tests indicated that the
dissimilar butt joints ruptured in the fusion zone.
First record of the genus Raunolina (Hemiptera: Fulgoroidea: Caliscelidae) from tropical Africa with description of two new species from Sudan and Saudi Arabia
Authors: Gnezdilov Vladimir M.
Published: May 2018

Raunolina Gnezdilov & Wilson, 2006 erected as a subgenus of Perissana Metcalf, 1952 is upgraded to generic level. Raunolina remanei sp. nov. is described from northeastern Sudan, which is the first record of the genus and the tribe Adenissini Dlabola, 1980 from tropical Africa, and R. jeddahica sp. nov. is described from western Saudi Arabia. Two new combinations are provided: Raunolina circularis (Linnavuori, 1952), comb. nov. and Raunolina arabica (Gnezdilov & Wilson, 2006), comb. nov.; R. arabica is recorded for the first time from Yemen. A key to separate the genera Perissana and Raunolina as well as a key to species of Raunolina are given. The global distribution of Adenissini is discussed.
Description of immature stages of Laccobius kunashiricus, with a key to genera of the Laccobiini based on larval characters (Coleoptera: Hydrophilidae)
Authors: Minoshima Yûsuke N. , Iwata Yasuyuki , Fikáček Martin , Hayashi Masakazu
Published: May 2018

Immature stages of Laccobius (Laccobius) kunashiricus Shatrovskiy, 1984 are described based on specimens reared from adults collected in the field. The egg-case, all larval instars and pupa are described in detail, including primary and secondary chaetotaxy of the larval head. The biology of the species was observed and is briefly discussed. We also summarize the knowledge of immature stages of Laccobius Erichson, 1837 and provide a key to identify larvae of the known Laccobiini genera.
Effect of Tungsten and Molybdenum on the Crystallization, Microstructure and Properties of Silumin 226
Authors: Szymczak T. , Gumienny G. , Pacyniak T. , Walas K.
Published: May 2018

The work presents the results of the examinations of silumin 226 as well as a silumin produced on its basis containing a W and Mo addition introduced in the amount of 0.1; 0.2; 0.3 and 0.4% of both elements simultaneously. Investigations of the crystallization process of the silumins by the TDA method were conducted. Also, a microscopic analysis of their microstructure was performed and their basic mechanical properties were determined. Microstructure tests were made on casts produced in an TDA sampler as well as by the pressure method. The investigations exhibited a change in the course of crystallization of the silumin containing 0.3 and 0.4% W and Mo with respect to silumin 226 and the silumin with the addition of 0.1 and 0.2%. The presence of additional phases which did not occur in the case of lower addition contents was established in the silumin containing 0.3-0.4% W and Mo, regardless of the applied casting technology. The tests showed the possibility of increasing the tensile strength Rm, the proof stress Rp0,2 and the unit elongation A of the silumin as a result of a simultaneous introduction of the W and Mo addition. The highest values of Rm, Rp0,2 and A were obtained in the silumins with the additions of these elements within the range of 0.1-0.2% each.
Strongly J-Clean Skew Triangular Matrix Rings
Authors: Kurtulmaz Yosum
Published: May 2018

Let R be an arbitrary ring with identity. An element a ∈ R is strongly J-clean if there exist an idempotent e ∈ R and element w ∈ J(R) such that a = e + w and ew = ew. A ring R is strongly J-clean in case every element in R is strongly J-clean. In this note, we investigate the strong J-cleanness of the skew triangular matrix ring Tn(R, σ) over a local ring R, where σ is an endomorphism of R and n = 2, 3, 4.
Generalized Outer Synchronization of Stochastic Neural Networks With Time-Varying Delays
Authors: He Ping
Published: May 2018

In this paper, generalized outer synchronization between two different stochastic coupled complex dynamical networks with time-varying delays has been investigated. A novel controller is given and the stochastic invariance principle is applied. A stochastic disturbance which is described in term of a Brownian motion are considered in complex dynamical networks. Moreover, some sufficient conditions are derived to ensure generalized outer synchronization of stochastic neural networks. Surprisingly, it is found that complex networks with different structure can be synchronized.