bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplemental materials and methods, supplemental references and supplemental figure legends from Loss of RASSF4 Expression in Multiple Myeloma Promotes RAS-Driven Malignant Progression
Authors: De Smedt Eva , Maes Ken , Verhulst Stefaan , Lui Hui , Kassambara Alboukadel , Maes Anke , Robert Nicolas , Heirman Carlo , Cakana Andrew , Hose Dirk , Breckpot Karine , van Grunsven Leo A. , De Veirman Kim , Menu Eline , Vanderkerken Karin , Moreaux Jérôme , De Bruyne Elke
Published: April 2023

Information about material and methods, that further support the date described in this article. Additional references and legends to the supplmental figures are also provided.
Figure S9 from TGFβ Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis
Authors: Principe Daniel R. , DeCant Brian , Mascariñas Emman , Wayne Elizabeth A. , Diaz Andrew M. , Akagi Naomi , Hwang Rosa , Pasche Boris , Dawson David W. , Fang Deyu , Bentrem David J. , Munshi Hidayatullah G. , Jung Barbara , Grippo Paul J.
Published: April 2023

Figure S9. Global TGFBR Deficiency Permits a CD8 Response
Figure S7 from TGFβ Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis
Authors: Principe Daniel R. , DeCant Brian , Mascariñas Emman , Wayne Elizabeth A. , Diaz Andrew M. , Akagi Naomi , Hwang Rosa , Pasche Boris , Dawson David W. , Fang Deyu , Bentrem David J. , Munshi Hidayatullah G. , Jung Barbara , Grippo Paul J.
Published: April 2023

Figure S7. Global TGFBR Increases GranzymeB Mediated Cytotoxicity in the GI Tract
Supplementary Figure Legends from p27 Is a Candidate Prognostic Biomarker and Metastatic Promoter in Osteosarcoma
Authors: Li Yiting , Nakka Manjula , Kelly Aaron J. , Lau Ching C. , Krailo Mark , Barkauskas Donald A. , Hicks John M. , Man Tsz-Kwong
Published: April 2023

This file contains the legends of the supplementary figures.
Supplemental Materials and Methods from Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression
Authors: Boulay Pierre-Luc , Mitchell Louise , Turpin Jason , Huot-Marchand Julie-Émilie , Lavoie Cynthia , Sanguin-Gendreau Virginie , Jones Laura , Mitra Shreya , Livingstone Julie M. , Campbell Shirley , Hallett Michael , Mills Gordon B. , Park Morag , Chodosh Lewis , Strathdee Douglas , Norman Jim C. , Muller William J.
Published: April 2023

This file contains supplemental materials and methods
Supplementary Figure Legends from Heparanase 2 Attenuates Head and Neck Tumor Vascularity and Growth
Authors: Gross-Cohen Miriam , Feld Sari , Doweck Ilana , Neufeld Gera , Hasson Peleg , Arvatz Gil , Barash Uri , Naroditsky Inna , Ilan Neta , Vlodavsky Israel
Published: April 2023

Legends for Supplementary Figures S1-S7.
Supplemental Figure 5 FIP1C is not distribute at adjacent junctional complexes. Clinical relevance of FIP1C in Her2-positive breast cancer patients from Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression
Authors: Boulay Pierre-Luc , Mitchell Louise , Turpin Jason , Huot-Marchand Julie-Émilie , Lavoie Cynthia , Sanguin-Gendreau Virginie , Jones Laura , Mitra Shreya , Livingstone Julie M. , Campbell Shirley , Hallett Michael , Mills Gordon B. , Park Morag , Chodosh Lewis , Strathdee Douglas , Norman Jim C. , Muller William J.
Published: April 2023

The Supplemental Figure 5 demonstrates that FIP1C does not co-localize with E-cadherin and therefore FIP1C acts indirectly on E-cadherin status in ErbB2-driven model. Additionnally, this Supplemental Figure 5 shows that FIP1C levels is inversely correlated with Her2 grade status as reported by TCGA human data sets.
Supplemental Figure 2 In vitro role of FIP1C in regulating cell proliferation in ErbB2/neuNDL primary cells from Rab11-FIP1C Is a Critical Negative Regulator in ErbB2-Mediated Mammary Tumor Progression
Authors: Boulay Pierre-Luc , Mitchell Louise , Turpin Jason , Huot-Marchand Julie-Émilie , Lavoie Cynthia , Sanguin-Gendreau Virginie , Jones Laura , Mitra Shreya , Livingstone Julie M. , Campbell Shirley , Hallett Michael , Mills Gordon B. , Park Morag , Chodosh Lewis , Strathdee Douglas , Norman Jim C. , Muller William J.
Published: April 2023

The Supplemental Figure 2 shows alternative strategy to understand and investigate the pathobiological function of FIP1C in ErbB2-mediated breast cancer progression. Briefly, this supplemental data sets report that we established primary ErbB2/neuNDL cell line and generated FIP1C-overexpressed (His-FIP1C) and FIP1C-depleted cell lines (shFIP1C)to examine cell proliferation, cell motility and β1-integrin trafficking in a ErbB2-dependent context. Our results show that overexpression of FIP1C decrease cell proliferation and EGF-promoted cell invasion in an ErbB2-dependent context. However, the depletion of FIP1C using shRNA approach leads into increase cell proliferation as well as cell migration and invasion fate in an ErbB2-dependent context. This in vitro characterization of FIP1C-proficient and -deficient ErbB2/neuNDL cell lines is a supplement panel to support the Figure 2.
Supplementary Materials and Methods from A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors
Authors: Liu Xiaojun , Ranganathan Raghuveer , Jiang Shuguang , Fang Chongyun , Sun Jing , Kim Soyeon , Newick Kheng , Lo Albert , June Carl H. , Zhao Yangbing , Moon Edmund K.
Published: April 2023

Cell lines and cell culture conditions, antibodies, cytokine production of restimulated T-cells, animals, and stastical analysis.
Supplementary Figure 6 from Stress Chaperone Mortalin Contributes to Epithelial-to-Mesenchymal Transition and Cancer Metastasis
Authors: Na Youjin , Kaul Sunil C. , Ryu Jihoon , Lee Jung-Sun , Ahn Hyo Min , Kaul Zeenia , Kalra Rajkumar S. , Li Ling , Widodo Nashi , Yun Chae-Ok , Wadhwa Renu
Published: April 2023

Correlation of mortalin amplification with other genes involved in human carcinogenesis. (A) Network showing correlation of mortalin amplification in Kidney Renal Clear Cell Carcinoma (RCCC, TCGA database) with other genes is shown. (B) Amplification of mortalin locus showed tight association and mutual exclusiveness with FGF1 and p53, respectively.
Supplementary Figure 5 from A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors
Authors: Liu Xiaojun , Ranganathan Raghuveer , Jiang Shuguang , Fang Chongyun , Sun Jing , Kim Soyeon , Newick Kheng , Lo Albert , June Carl H. , Zhao Yangbing , Moon Edmund K.
Published: April 2023

Effect of tailless/signal-dead PD1 on in-vivo CAR T cell anti-tumor control.
Supplementary Figure 5 from Stress Chaperone Mortalin Contributes to Epithelial-to-Mesenchymal Transition and Cancer Metastasis
Authors: Na Youjin , Kaul Sunil C. , Ryu Jihoon , Lee Jung-Sun , Ahn Hyo Min , Kaul Zeenia , Kalra Rajkumar S. , Li Ling , Widodo Nashi , Yun Chae-Ok , Wadhwa Renu
Published: April 2023

Mortalin overexpression caused increase in MMP-2 and MMP-9.
Supplementary Figure 3 from A Chimeric Switch-Receptor Targeting PD1 Augments the Efficacy of Second-Generation CAR T Cells in Advanced Solid Tumors
Authors: Liu Xiaojun , Ranganathan Raghuveer , Jiang Shuguang , Fang Chongyun , Sun Jing , Kim Soyeon , Newick Kheng , Lo Albert , June Carl H. , Zhao Yangbing , Moon Edmund K.
Published: April 2023

Enhanced in-vitro killing of EMMESO-PDL1 tumor targets by PD1CD28 modification.
Supplementary Table S5 from Long Noncoding RNA pancEts-1 Promotes Neuroblastoma Progression through hnRNPK-Mediated β-Catenin Stabilization
Authors: Li Dan , Wang Xiaojing , Mei Hong , Fang Erhu , Ye Lin , Song Huajie , Yang Feng , Li Huanhuan , Huang Kai , Zheng Liduan , Tong Qiangsong
Published: April 2023

Table S5 shows the hnRNPK expression in human NB tissues
Supplementary Figure 1 from Novel ß-HPV49 Transgenic Mouse Model of Upper Digestive Tract Cancer
Authors: Viarisio Daniele , Müller-Decker Karin , Zanna Paola , Kloz Ulrich , Aengeneyndt Birgit , Accardi Rosita , Flechtenmacher Christa , Gissmann Lutz , Tommasino Massimo
Published: April 2023

Tumor burden in WT and HPV E6/E7-Tg mouse lines of HPV type 38 line 187 and type 49 line 2 after DMBA/TPA treatment
Supplemental Table S3 from Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma
Authors: Tian Yuan , Wong Vincent W.S. , Wong Grace L.H. , Yang Weiqin , Sun Hanyong , Shen Jiayun , Tong Joanna H.M. , Go Minnie Y.Y. , Cheung Yue S. , Lai Paul B.S. , Zhou Mingyan , Xu Gang , Huang Tim H.M. , Yu Jun , To Ka F. , Cheng Alfred S.L. , Chan Henry L.Y.
Published: April 2023

The primers used in this study.
Supplemental Table S2 from Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma
Authors: Tian Yuan , Wong Vincent W.S. , Wong Grace L.H. , Yang Weiqin , Sun Hanyong , Shen Jiayun , Tong Joanna H.M. , Go Minnie Y.Y. , Cheung Yue S. , Lai Paul B.S. , Zhou Mingyan , Xu Gang , Huang Tim H.M. , Yu Jun , To Ka F. , Cheng Alfred S.L. , Chan Henry L.Y.
Published: April 2023

Clinicopathological information of the NAFLD-associated HCC patients.
Supplementary Figures from Macrophage Blockade Using CSF1R Inhibitors Reverses the Vascular Leakage Underlying Malignant Ascites in Late-Stage Epithelial Ovarian Cancer
Authors: Moughon Diana L. , He Huanhuan , Schokrpur Shiruyeh , Jiang Ziyue Karen , Yaqoob Madeeha , David John , Lin Crystal , Iruela-Arispe M. Luisa , Dorigo Oliver , Wu Lily
Published: April 2023

Supplementary Figure 1: Murine ID8 EOC models. Supplementary Figure 2: CSF1R and CSF-1 in ovarian cancer cells. Supplementary Figure 3: Systemic effects of GW2580 treatment. Supplementary Figure 4: Tumor growth and spread is reduced with CSF1R inhibition. Supplementary Figure 5: ID8 model ascites is similar to EOC patient ascites.
Supplemental Table S1 from Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma
Authors: Tian Yuan , Wong Vincent W.S. , Wong Grace L.H. , Yang Weiqin , Sun Hanyong , Shen Jiayun , Tong Joanna H.M. , Go Minnie Y.Y. , Cheung Yue S. , Lai Paul B.S. , Zhou Mingyan , Xu Gang , Huang Tim H.M. , Yu Jun , To Ka F. , Cheng Alfred S.L. , Chan Henry L.Y.
Published: April 2023

Targeted gene expression profiling of 115 chromatin regulators in murine obesity-promoted HCC models.
Supplementary Figure 6 from Infiltrating Macrophages Induce ERα Expression through an IL17A-mediated Epigenetic Mechanism to Sensitize Endometrial Cancer Cells to Estrogen
Authors: Ning Chengcheng , Xie Bingying , Zhang Lin , Li Chunsheng , Shan Weiwei , Yang Bingyi , Luo Xuezhen , Gu Chao , He Qizhi , Jin Hongyan , Chen Xiaojun , Zhang Zhenbo , Feng Youji
Published: April 2023

Semi-quantitative evaluation of the immunohistochemical staining of IL-17A, TET1, 5-hmC, and ERα expression in endometrial hyperplasia and cancer lesions
Supplementary Figure 3 from Infiltrating Macrophages Induce ERα Expression through an IL17A-mediated Epigenetic Mechanism to Sensitize Endometrial Cancer Cells to Estrogen
Authors: Ning Chengcheng , Xie Bingying , Zhang Lin , Li Chunsheng , Shan Weiwei , Yang Bingyi , Luo Xuezhen , Gu Chao , He Qizhi , Jin Hongyan , Chen Xiaojun , Zhang Zhenbo , Feng Youji
Published: April 2023

The expression pattern of ERα in different cell lines
supplementary tables from In Vivo Visualization and Characterization of Epithelial–Mesenchymal Transition in Breast Tumors
Authors: Zhao Zhen , Zhu Xiaoping , Cui Kemi , Mancuso James , Federley Richard , Fischer Kari , Teng Gao-jun , Mittal Vivek , Gao Dingcheng , Zhao Hong , Wong Stephen T.C.
Published: April 2023

Table 1: Distribution of the GFP+ cells in whole tumor central vs peripheral area and tumor lobule central vs peripheral area. Table 2: RNAseq gene expressions of growth factor receptors in sorted RFP+ and GFP+ cells.
supplementary figure legends from In Vivo Visualization and Characterization of Epithelial–Mesenchymal Transition in Breast Tumors
Authors: Zhao Zhen , Zhu Xiaoping , Cui Kemi , Mancuso James , Federley Richard , Fischer Kari , Teng Gao-jun , Mittal Vivek , Gao Dingcheng , Zhao Hong , Wong Stephen T.C.
Published: April 2023

supplementary figure legends
Supplementary information from GADD45β Loss Ablates Innate Immunosuppression in Cancer
Authors: Verzella Daniela , Bennett Jason , Fischietti Mariafausta , Thotakura Anil K. , Recordati Camilla , Pasqualini Fabio , Capece Daria , Vecchiotti Davide , D'Andrea Daniel , Di Francesco Barbara , De Maglie Marcella , Begalli Federica , Tornatore Laura , Papa Salvatore , Lawrence Toby , Forbes Stuart J. , Sica Antonio , Alesse Edoardo , Zazzeroni Francesca , Franzoso Guido
Published: April 2023

Supplemental Figure Legends and Supplementary Materials and Methods
Figure S5 from GADD45β Loss Ablates Innate Immunosuppression in Cancer
Authors: Verzella Daniela , Bennett Jason , Fischietti Mariafausta , Thotakura Anil K. , Recordati Camilla , Pasqualini Fabio , Capece Daria , Vecchiotti Davide , D'Andrea Daniel , Di Francesco Barbara , De Maglie Marcella , Begalli Federica , Tornatore Laura , Papa Salvatore , Lawrence Toby , Forbes Stuart J. , Sica Antonio , Alesse Edoardo , Zazzeroni Francesca , Franzoso Guido
Published: April 2023

Increased Immune Infiltration, Proinflammatory TAM Activation and Effects of CD8+ T-Cell Depletion in Fibrosarcomas and/or Ovarian Tumours from Gadd45b-/- mice
Supplementary Tables S1-S4 from MEF2D Transduces Microenvironment Stimuli to ZEB1 to Promote Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
Authors: Su Li , Luo Yongli , Yang Zhi , Yang Jing , Yao Chao , Cheng Feifei , Shan Juanjuan , Chen Jun , Li Fangfang , Liu Limei , Liu Chungang , Xu Yanmin , Jiang Lupin , Guo Deyu , Prieto Jesus , Ávila Matías A. , Shen Junjie , Qian Cheng
Published: April 2023

MEF2D expression in colorectal carcinoma, paired adjacent tissue and normal (S1); Associations of MEF2D expression with clinicopathological features in CRC (S2); Primers used in this study (S3); Antibodies used in this study (S4).
Supplementary Methods and References from MEF2D Transduces Microenvironment Stimuli to ZEB1 to Promote Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
Authors: Su Li , Luo Yongli , Yang Zhi , Yang Jing , Yao Chao , Cheng Feifei , Shan Juanjuan , Chen Jun , Li Fangfang , Liu Limei , Liu Chungang , Xu Yanmin , Jiang Lupin , Guo Deyu , Prieto Jesus , Ávila Matías A. , Shen Junjie , Qian Cheng
Published: April 2023

Description of additional methods and procedures used in the study. Also includes Supplementary References.
Figure S3 from GADD45β Loss Ablates Innate Immunosuppression in Cancer
Authors: Verzella Daniela , Bennett Jason , Fischietti Mariafausta , Thotakura Anil K. , Recordati Camilla , Pasqualini Fabio , Capece Daria , Vecchiotti Davide , D'Andrea Daniel , Di Francesco Barbara , De Maglie Marcella , Begalli Federica , Tornatore Laura , Papa Salvatore , Lawrence Toby , Forbes Stuart J. , Sica Antonio , Alesse Edoardo , Zazzeroni Francesca , Franzoso Guido
Published: April 2023

Increased Hepatocellular Apoptosis, but Not Proliferation in DEN-Treated Gadd45b-/- Mice
Supplementary Figure S4 from MEF2D Transduces Microenvironment Stimuli to ZEB1 to Promote Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
Authors: Su Li , Luo Yongli , Yang Zhi , Yang Jing , Yao Chao , Cheng Feifei , Shan Juanjuan , Chen Jun , Li Fangfang , Liu Limei , Liu Chungang , Xu Yanmin , Jiang Lupin , Guo Deyu , Prieto Jesus , Ávila Matías A. , Shen Junjie , Qian Cheng
Published: April 2023

MEF2D is essential for tumorigenesis in vivo.
Supplemental Figure Legends from MEF2D Transduces Microenvironment Stimuli to ZEB1 to Promote Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
Authors: Su Li , Luo Yongli , Yang Zhi , Yang Jing , Yao Chao , Cheng Feifei , Shan Juanjuan , Chen Jun , Li Fangfang , Liu Limei , Liu Chungang , Xu Yanmin , Jiang Lupin , Guo Deyu , Prieto Jesus , Ávila Matías A. , Shen Junjie , Qian Cheng
Published: April 2023

Legends for Supplementary Figures S1-S4.
Supplemental Figure legends from Inducing Differentiation of Premalignant Hepatic Cells as a Novel Therapeutic Strategy in Hepatocarcinoma
Authors: Wolf Benita , Krieg Kathrin , Falk Christine , Breuhahn Kai , Keppeler Hildegard , Biedermann Tilo , Schmid Evi , Warmann Steven , Fuchs Joerg , Vetter Silvia , Thiele Dennis , Nieser Maike , Avci-Adali Meltem , Skokowa Yulia , Schöls Ludger , Hauser Stefan , Ringelhan Marc , Yevsa Tetyana , Heikenwalder Mathias , Kossatz-Boehlert Uta
Published: April 2023

Figure legends
Supplemental Table S2 from Efficacy and Mechanisms of Aerobic Exercise on Cancer Initiation, Progression, and Metastasis: A Critical Systematic Review of In Vivo Preclinical Data
Authors: Ashcraft Kathleen A. , Peace Ralph M. , Betof Allison S. , Dewhirst Mark W. , Jones Lee W.
Published: April 2023

Overview of study characteristics
Supplemental Table S1 from Efficacy and Mechanisms of Aerobic Exercise on Cancer Initiation, Progression, and Metastasis: A Critical Systematic Review of In Vivo Preclinical Data
Authors: Ashcraft Kathleen A. , Peace Ralph M. , Betof Allison S. , Dewhirst Mark W. , Jones Lee W.
Published: April 2023

Concept Vocabulary
Supplementary Table S5 from Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1
Authors: Dubey Ramin , Lebensohn Andres M. , Bahrami-Nejad Zahra , Marceau Caleb , Champion Magali , Gevaert Olivier , Sikic Branimir I. , Carette Jan E. , Rohatgi Rajat
Published: April 2023

Spreadsheet of RNAseq data for Figure 3.
Supplementary Table S3 from Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1
Authors: Dubey Ramin , Lebensohn Andres M. , Bahrami-Nejad Zahra , Marceau Caleb , Champion Magali , Gevaert Olivier , Sikic Branimir I. , Carette Jan E. , Rohatgi Rajat
Published: April 2023

Hits from Doxorubicin Forwards Genetic Screen.
Supplementary Tables from Transcriptional Induction of Periostin by a Sulfatase 2–TGFβ1–SMAD Signaling Axis Mediates Tumor Angiogenesis in Hepatocellular Carcinoma
Authors: Chen Gang , Nakamura Ikuo , Dhanasekaran Renumathy , Iguchi Eriko , Tolosa Ezequiel J. , Romecin Paola A. , Vera Renzo E. , Almada Luciana L. , Miamen Alexander G. , Chaiteerakij Roongruedee , Zhou Mengtao , Asiedu Michael K. , Moser Catherine D. , Han Shaoshan , Hu Chunling , Banini Bubu A. , Oseini Abdul M. , Chen Yichun , Fang Yong , Yang Dongye , Shaleh Hassan M. , Wang Shaoqing , Wu Dehai , Song Tao , Lee Ju-Seog , Thorgeirsson Snorri S. , Chevet Eric , Shah Vijay H. , Fernandez-Zapico Martin E. , Roberts Lewis R.
Published: April 2023

Supplementary Table 1 List of antibodies, reagents and kits used in the study Supplementary Table 2 List of primers used in the study Supplementary Table 3 Comprehensive literature search of angiogenic regulators in HCC Supplementary Table 4 Correlation of 178 genes related to angiogenesis in HCC with SULF2 expression in human HCC microarray gene analysis
Supplementary Figures S1-S5 from Chromatin-Remodeling Complex SWI/SNF Controls Multidrug Resistance by Transcriptionally Regulating the Drug Efflux Pump ABCB1
Authors: Dubey Ramin , Lebensohn Andres M. , Bahrami-Nejad Zahra , Marceau Caleb , Champion Magali , Gevaert Olivier , Sikic Branimir I. , Carette Jan E. , Rohatgi Rajat
Published: April 2023

Overview of the screening strategy in haploid cells (S1); Correlation between ABCB1 and SMARCB1 mRNA expression levels across multiple human cancers represented in the TCGA database (S2); Correlation between SMARCB1 expression and doxorubicin resistance across multiple human cancers represented in the TCGA database (S3); SMARCB1 loss leads to ABCB1 upregulation, drug resistance and reduced Dox accumulation (S4); Hierarchical clustering reveals multiple classes of genes that are differentially expressed in WT Hap1 cells compared to Hap1 cells lacking SMARCB1 (S5).
Supplementary Methods from NOTCH Signaling Regulates Asymmetric Cell Fate of Fast- and Slow-Cycling Colon Cancer–Initiating Cells
Authors: Srinivasan Tara , Walters Jewell , Bu Pengcheng , Than Elaine Bich , Tung Kuei-Ling , Chen Kai-Yuan , Panarelli Nicole , Milsom Jeff , Augenlicht Leonard , Lipkin Steven M. , Shen Xiling
Published: April 2023

Contains information about antibodies used for immunofluorescence and Western blotting and primers for RT-PCR.
Figure S3 from UGT2B17 Expedites Progression of Castration-Resistant Prostate Cancers by Promoting Ligand-Independent AR Signaling
Authors: Li Haolong , Xie Ning , Chen Ruiqi , Verreault Mélanie , Fazli Ladan , Gleave Martin E. , Barbier Olivier , Dong Xuesen
Published: April 2023

Figure S3: AR knockdown diminished UGT2B17-stimulated gene upregulation
Supplementary Table 6 from Landscape of Combination Immunotherapy and Targeted Therapy to Improve Cancer Management
Authors: Colli Leandro M. , Machiela Mitchell J. , Zhang Han , Myers Timothy A. , Jessop Lea , Delattre Olivier , Yu Kai , Chanock Stephen J.
Published: April 2023

2016 Cancer Statistics data used to normalize for cancer incidence rates in the US
Supplementary Material and Methods from NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress–Induced DPP3–KEAP1 Interaction
Authors: Lu Kevin , Alcivar Allen L. , Ma Jianglin , Foo Tzeh Keong , Zywea Susan , Mahdi Amar , Huo Yanying , Kensler Thomas W. , Gatza Michael L. , Xia Bing
Published: April 2023

Quantification of mRNA amount, qRT-PCR primer sequences, and transfection and immunoprecipitation methods.
Supplementary Materials from Inhibiting Mitochondrial DNA Ligase IIIα Activates Caspase 1–Dependent Apoptosis in Cancer Cells
Authors: Sallmyr Annahita , Matsumoto Yoshihiro , Roginskaya Vera , Van Houten Bennett , Tomkinson Alan E.
Published: April 2023

Supplementary Materials and methods plus legends for six supplementary figures
Supplementary Figure 3 from NRF2 Induction Supporting Breast Cancer Cell Survival Is Enabled by Oxidative Stress–Induced DPP3–KEAP1 Interaction
Authors: Lu Kevin , Alcivar Allen L. , Ma Jianglin , Foo Tzeh Keong , Zywea Susan , Mahdi Amar , Huo Yanying , Kensler Thomas W. , Gatza Michael L. , Xia Bing
Published: April 2023

High DPP3 mRNA expression correlates with poor relapse-free survival (RFS) of breast cancer patients in the Kaplan-Meier Plotter database.
Suppl Fig. 3 from Inhibiting Mitochondrial DNA Ligase IIIα Activates Caspase 1–Dependent Apoptosis in Cancer Cells
Authors: Sallmyr Annahita , Matsumoto Yoshihiro , Roginskaya Vera , Van Houten Bennett , Tomkinson Alan E.
Published: April 2023

Panel A. Effect of L67 on the cell cycle distribution of synchronized HeLa cells, HeLa Rho minus cells and HeLa cells expressing mitochondrially targeted E. coli DNA ligase. Panel B. Effect of L67 on bromodeoxyuridine incorporation by HeLa cells, HeLa Rho minus cells and HeLa cells expressing mitochondrially targeted E. coli DNA ligase.
Supplemental Information from Quantifying the Dynamics of Field Cancerization in Tobacco-Related Head and Neck Cancer: A Multiscale Modeling Approach
Authors: Ryser Marc D. , Lee Walter T. , Ready Neal E. , Leder Kevin Z. , Foo Jasmine
Published: April 2023

This file contains four sections with mathematical and methodological details, including one supplemental figure. Section S1: Based on the mesoscopic mathematical model, the likelihood function for Bayesian parameter inference is derived. Section S2: A priori parameter estimates are justified based on experimental findings from the literature. Section S3: The probabilistic distributions of field size and multiplicity are derived in detail. Section S4: Age-specific incidence data is compared to the classical Armitage-Doll model of multistage carcinogenesis. Figure S1: The Armitage-Doll model fit to age-specific incidence data is visualized
Supplementary Table and Figure Legends from High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells
Authors: Horn Thomas , Ferretti Stéphane , Ebel Nicolas , Tam Angela , Ho Samuel , Harbinski Fred , Farsidjani Ali , Zubrowski Matthew , Sellers William R. , Schlegel Robert , Porter Dale , Morris Erick , Wuerthner Jens , Jeay Sébastien , Greshock Joel , Halilovic Ensar , Garraway Levi A. , Caponigro Giordano , Lehár Joseph
Published: April 2023

Legend for Supplementary Tables S1-S6 and Supplementary Figures S1-S15.
Supplementary Table S6 from High-Order Drug Combinations Are Required to Effectively Kill Colorectal Cancer Cells
Authors: Horn Thomas , Ferretti Stéphane , Ebel Nicolas , Tam Angela , Ho Samuel , Harbinski Fred , Farsidjani Ali , Zubrowski Matthew , Sellers William R. , Schlegel Robert , Porter Dale , Morris Erick , Wuerthner Jens , Jeay Sébastien , Greshock Joel , Halilovic Ensar , Garraway Levi A. , Caponigro Giordano , Lehár Joseph
Published: April 2023

Summarized results for high-order combinations in DLD-1, RKO, HT-29, and LS-180 cell lines.
Supplementary figures and tables from Identification of a Natural Killer Cell Receptor Allele That Prolongs Survival of Cytomegalovirus-Positive Glioblastoma Patients
Authors: Dominguez–Valentin Mev , Gras Navarro Andrea , Rahman Aminur Mohummad , Kumar Surendra , Retière Christèle , Ulvestad Elling , Kristensen Vessela , Lund-Johansen Morten , Lie Benedicte Alexandra , Enger Per Øyvind , Njølstad Gro , Kristoffersen Einar , Lie Stein Atle , Chekenya Martha
Published: April 2023

Supplementary figures and tables for bioinformatic analyses. Fig S1 TCGA bioinformatics analysis workflow chart Fig S2 alignment plots of quality score accuracy Fig S3 Screenshot of region of interest on Chr 19 indicating genotype information on KIR2DS4 variant call Table SI Characteristics of the patients and control population used in this study Table SII Clinical data of 300 GBM patient obtained from The Cancer Genome Atlas (TCGA) project. Table SIII Description of the 2504 control population from 1000 Genome Project. Table SIV Antibodies used for Flow cytometry
Figure S7 from Deletion of Lactate Dehydrogenase-A in Myeloid Cells Triggers Antitumor Immunity
Authors: Seth Pankaj , Csizmadia Eva , Hedblom Andreas , Vuerich Marta , Xie Han , Li Mailin , Longhi Maria Serena , Wegiel Barbara
Published: April 2023

Expression of CD86 and PDL-1 in macrophages lacking LDH-A.
Figure S6 from Deletion of Lactate Dehydrogenase-A in Myeloid Cells Triggers Antitumor Immunity
Authors: Seth Pankaj , Csizmadia Eva , Hedblom Andreas , Vuerich Marta , Xie Han , Li Mailin , Longhi Maria Serena , Wegiel Barbara
Published: April 2023

mRNA expression of activation markers and cytokines in CD8 T cells.
Figure S2 from Deletion of Lactate Dehydrogenase-A in Myeloid Cells Triggers Antitumor Immunity
Authors: Seth Pankaj , Csizmadia Eva , Hedblom Andreas , Vuerich Marta , Xie Han , Li Mailin , Longhi Maria Serena , Wegiel Barbara
Published: April 2023

Co-culture of RAW macrophages and cancer cells.
Supplementary Tables and References from BRCA2 Hypomorphic Missense Variants Confer Moderate Risks of Breast Cancer
Authors: Shimelis Hermela , Mesman Romy L.S. , Von Nicolai Catharina , Ehlen Asa , Guidugli Lucia , Martin Charlotte , Calléja Fabienne M.G.R. , Meeks Huong , Hallberg Emily , Hinton Jamie , Lilyquist Jenna , Hu Chunling , Aalfs Cora M. , Aittomäki Kristiina , Andrulis Irene , Anton-Culver Hoda , Arndt Volker , Beckmann Matthias W. , Benitez Javier , Bogdanova Natalia V. , Bojesen Stig E. , Bolla Manjeet K. , Borresen-Dale Anne-Lise , Brauch Hiltrud , Brennan Paul , Brenner Hermann , Broeks Annegien , Brouwers Barbara , Brüning Thomas , Burwinkel Barbara , Chang-Claude Jenny , Chenevix-Trench Georgia , Cheng Ching-Yu , Choi Ji-Yeob , Collée J. Margriet , Cox Angela , Cross Simon S. , Czene Kamila , Darabi Hatef , Dennis Joe , Dörk Thilo , dos-Santos-Silva Isabel , Dunning Alison M. , Fasching Peter A. , Figueroa Jonine , Flyger Henrik , García-Closas Montserrat , Giles Graham G. , Glendon Gord , Guénel Pascal , Haiman Christopher A. , Hall Per , Hamann Ute , Hartman Mikael , Hogervorst Frans B. , Hollestelle Antoinette , Hopper John L. , Ito Hidemi , Jakubowska Anna , Kang Daehee , Kosma Veli-Matti , Kristensen Vessela , Lai Kah-Nyin , Lambrechts Diether , Marchand Loic Le , Li Jingmei , Lindblom Annika , Lophatananon Artitaya , Lubinski Jan , Machackova Eva , Mannermaa Arto , Margolin Sara , Marme Frederik , Matsuo Keitaro , Miao Hui , Michailidou Kyriaki , Milne Roger L. , Muir Kenneth , Neuhausen Susan L. , Nevanlinna Heli , Olson Janet E. , Olswold Curtis , Oosterwijk Jan J.C. , Osorio Ana , Peterlongo Paolo , Peto Julian , Pharoah Paul D.P. , Pylkäs Katri , Radice Paolo , Rashid Muhammad Usman , Rhenius Valerie , Rudolph Anja , Sangrajrang Suleeporn , Sawyer Elinor J. , Schmidt Marjanka K. , Schoemaker Minouk J. , Seynaeve Caroline , Shah Mitul , Shen Chen-Yang , Shrubsole Martha , Shu Xiao-Ou , Slager Susan , Southey Melissa C. , Stram Daniel O. , Swerdlow Anthony , Teo Soo H. , Tomlinson Ian , Torres Diana , Truong Thérèse , van Asperen Christi J. , van der Kolk Lizet E. , Wang Qin , Winqvist Robert , Wu Anna H. , Yu Jyh-Cherng , Zheng Wei , Zheng Ying , Leary Jennifer , Walker Logan , Foretova Lenka , Fostira Florentia , Claes Kathleen B.M. , Varesco Liliana , Moghadasi Setareh , Easton Douglas F. , Spurdle Amanda , Devilee Peter , Vrieling Harry , Monteiro Alvaro N.A. , Goldgar David E. , Carreira Aura , Vreeswijk Maaike P.G. , Couch Fergus J.
Published: April 2023

Table S1: Description of the BCAC studies contributing to COGS. Table S2: Predicted effects of BRCA1 and BRCA2 variants included in the iCOGS array on protein function. Table S3: Frequency of BRCA1 and BRCA2 variants from iCOGS in breast cancer cases and controls. Table S4: Family studies of Y3035S showing scores for each family by constant relative risk and 75% penetrance. Supplementary References.
Supplementary Figure S2 from Preclinical Evidence That 3′-Deoxy-3′-[18F]Fluorothymidine PET Can Visualize Recovery of Hematopoiesis after Gemcitabine Chemotherapy
Authors: Schelhaas Sonja , Held Annelena , Bäumer Nicole , Viel Thomas , Hermann Sven , Müller-Tidow Carsten , Jacobs Andreas H.
Published: April 2023

Immunohistochemical analysis of bone marrow tissue from the femur showed that proliferation was severely impaired within hours of gemcitabine therapy, whereas recovery could be noted thereafter.
Supplementary Figure S1. Isolation and characterization of breast cancer exosomes. from The Biodistribution and Immune Suppressive Effects of Breast Cancer–Derived Exosomes
Authors: Wen Shu Wen , Sceneay Jaclyn , Lima Luize Goncalves , Wong Christina S.F. , Becker Melanie , Krumeich Sophie , Lobb Richard J. , Castillo Vanessa , Wong Ke Ni , Ellis Sarah , Parker Belinda S. , Möller Andreas
Published: April 2023

(A) Morphological characterization of exosomes isolated from the conditioned media of EO771 and 4T1 breast cancer cells by transmission electron microscopy. The scale bar indicates 200 nm. B) Detection of exosome-markers, CD9 (25 kDa), TSG101 (47 kDa), HSP70 (70 kDa) and cis-Golgi marker, GM130 (112 kDa) proteins in breast cancer exosomes (E) and cell lysates (C) by Western blotting. (C) Representative example of size distrbution of breast cancer exosomes as measured by Tunable Resistive Pulse Sensing (TRSPS; Izon qNano). (D) Quantification of the number of exosomes produced by EO771 and 4T1 breast cancer cells per milliliter of conditioned media under same culturing conditions. (E) The number of exosomes released from 1E6 67NR and 4T1 cells as quantified using TRSPS. Results are represented as mean {plus minus} s.e.m.
Supplementary Figure Legends from The BRCA1-Δ11q Alternative Splice Isoform Bypasses Germline Mutations and Promotes Therapeutic Resistance to PARP Inhibition and Cisplatin
Authors: Wang Yifan , Bernhardy Andrea J. , Cruz Cristina , Krais John J. , Nacson Joseph , Nicolas Emmanuelle , Peri Suraj , van der Gulden Hanneke , van der Heijden Ingrid , O'Brien Shane W. , Zhang Yong , Harrell Maribel I. , Johnson Shawn F. , Candido Dos Reis Francisco J. , Pharoah Paul D. P. , Karlan Beth , Gourley Charlie , Lambrechts Diether , Chenevix-Trench Georgia , Olsson Håkan , Benitez Javier J. , Greene Mark H. , Gore Martin , Nussbaum Robert , Sadetzki Siegal , Gayther Simon A. , Kjaer Susanne K. , D'Andrea Alan D. , Shapiro Geoffrey I. , Wiest David L. , Connolly Denise C. , Daly Mary B. , Swisher Elizabeth M. , Bouwman Peter , Jonkers Jos , Balmaña Judith , Serra Violeta , Johnson Neil
Published: April 2023

Legend for Supplementary Figures S1-S6.
Supplementary Figures S1-S14 from Snail1-Dependent Activation of Cancer-Associated Fibroblast Controls Epithelial Tumor Cell Invasion and Metastasis
Authors: Alba-Castellón Lorena , Olivera-Salguero Rubén , Mestre-Farrera Aida , Peña Raúl , Herrera Mercedes , Bonilla Félix , Casal J. Ignacio , Baulida Josep , Peña Cristina , García de Herreros Antonio
Published: April 2023

Invasion of colon and breast cancer cell lines (S1); Mesenchymal Stem Cells enhance tumor invasion through Collagen or Matrigel matrices (S2); Invasion of HT-29 M6 is preceded by that of MSCs (S3); Generation of MSCs and MEFs depleted in Snail1 (S4); Generation of HT-29 M6 Snail1 CRISPR KO cells (S5); Genes differently regulated by HT-29 M6 in MSCs wild-type and Snail1 KO (S6); Prostaglandin E2 acts as a chemoattractant (S7); Inhibition of PGE2 signaling prevents HT-29 M6 invasion (S8); PGE2 stimulates HT-29 M6 invasion (S9); Snail1 expression in MSCs is required for the MSCs stimulation of invasion of different epithelial cell lines (S10); Expression of EP4 PGE2 receptor in epithelial cell lines (S11); Isolation of murine and human CAFs with different Snail1 levels (S12); Identification of ePyMT metastases in the lung (S13); Celecoxib does not modify tumor size in ePyMT-MSCs co-xenografts (S14).
Supplementary Figures 1 through 9 from Chemoresistance in Pancreatic Cancer Is Driven by Stroma-Derived Insulin-Like Growth Factors
Authors: Ireland Lucy , Santos Almudena , Ahmed Muhammad S. , Rainer Carolyn , Nielsen Sebastian R. , Quaranta Valeria , Weyer-Czernilofsky Ulrike , Engle Danielle D. , Perez-Mancera Pedro A. , Coupland Sarah E. , Taktak Azzam , Bogenrieder Thomas , Tuveson David A. , Campbell Fiona , Schmid Michael C. , Mielgo Ainhoa
Published: April 2023

Fig. S1. Primary M2-like macrophages express IGF-1 and IGF-2. Fig. S2. In the absence of chemotherapy, addition of MCM, IGF blockade or recombinant IGF does not affect proliferation or survival of pancreatic cancer cells. Fig.S3. MCM enhances resistance of pancreatic cancer cells to gemcitabine, 5-FU and paclitaxel in an IGF-dependent manner. Fig. S4. Biopsies from pancreatic cancer patients express activated Insulin and IGF1 receptors and are infiltrated by macrophages. Fig. S5. Mouse orthotopic pancreatic tumors are rich in macrophages and myofibroblasts. Fig. S6. Tumors from KPC mouse model express activated Insulin/IGF1 receptors. Fig. S7. Gating strategy used to FACS-sort tumor cells, immune cells and stromal cells. Fig. S8. Primary pancreatic myofibroblasts secrete IGF-1 and IGF-2. Fig. S9. IGF-1 and IGF-2 are expressed in the tumor microenvironment of PDA patients. Fig. S10. Gating strategies used to analyse tumor infiltrated immune cell populations. Fig. S11. IGF blockade decreases activation of Insulin and IGF1 receptors in pancreatic tumors. Fig. S12. Combination of 5-FU and paclitaxel with BI 836845 in a syngeneic orthotopic pancreatic cancer model.
Supplementary Materials and Methods, Supplementary Figures 1 through 5, and Supplementary Tables 1 through 3 from Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis
Authors: Tomkovich Sarah , Yang Ye , Winglee Kathryn , Gauthier Josee , Mühlbauer Marcus , Sun Xiaolun , Mohamadzadeh Mansour , Liu Xiuli , Martin Patricia , Wang Gary P. , Oswald Eric , Fodor Anthony A. , Jobin Christian
Published: April 2023

Supplementary Materials and Methods describing 16S rRNA sequencing analysis. Figure S1. PCR detection of F. nucleatum adhesins. Figure S2. ApcMin/+;Il10-/- mice have increased colon proliferation. Figure S3. Bacteria do not promote colon inflammation and tumorigenesis in ApcMin/+ mice. Figure S4. Microbiota promote proximal colon proliferation in ApcMin/+;Il10-/- mice. Figure S5. Colibactin promotes CRC development in AOM/Il10-/- mice. Table S1. Spearman correlations and corresponding p values from linear models used to generate Figure 3. Table S2. V1-V3 MiSeq Primers. Table S3. Accession numbers for 16S rRNA sequenced ApcMin/+;Il10-/- stool samples from Figure 3.
Supplementary Figure 2 from MNX1 Is Oncogenically Upregulated in African-American Prostate Cancer
Authors: Zhang Li , Wang Jianghua , Wang Yongquan , Zhang Yiqun , Castro Patricia , Shao Longjiang , Sreekumar Arun , Putluri Nagireddy , Guha Nilanjan , Deepak Saligrama , Padmanaban Arunkumar , Creighton Chad J. , Ittmann Michael
Published: April 2023

Supplementary Figure 2. MNX1 Protein Overexpression and Knockdown A. Western blot of MNX1 protein levels in two different stable clones of DU145 cells transfected with MNX1 expression vector (OE1 and OE2) versus empty vector controls. β-Actin is a loading control. B. Western blot of MNX1 protein levels in LNCaP cells and stable knockdown cells. LNCaP is untransfected LNCaP and SCR is LNCaP with scrambled vector control. shA, shB and shC are three different MNX1 shRNA transfected stable clones. Note that shB did not knockdown MNX1 and was not used for further experiments. beta-Actin is a loading control.
Supplementary Table S1. from SMYD3-Mediated H2A.Z.1 Methylation Promotes Cell Cycle and Cancer Proliferation
Authors: Tsai Cheng-Hui , Chen Yun-Ju , Yu Chia-Jung , Tzeng Shiou-Ru , Wu I-Chen , Kuo Wen-Hung , Lin Ming-Chieh , Chan Nei-Li , Wu Kou-Juey , Teng Shu-Chun
Published: April 2023

Supplementary Table S1. List of methylated histone proteins identified from in vitro HMT assay on calf thymus extracts followed by LC-MS/MS analysis
Supplementary Information from SMYD3-Mediated H2A.Z.1 Methylation Promotes Cell Cycle and Cancer Proliferation
Authors: Tsai Cheng-Hui , Chen Yun-Ju , Yu Chia-Jung , Tzeng Shiou-Ru , Wu I-Chen , Kuo Wen-Hung , Lin Ming-Chieh , Chan Nei-Li , Wu Kou-Juey , Teng Shu-Chun
Published: April 2023

Supplementary Materials and Methods, Supplementary Figure Legends and Supplementary Tables
supplemental figures combined from Immune-Stimulatory Effects of Rapamycin Are Mediated by Stimulation of Antitumor γδ T Cells
Authors: Dao Vinh , Liu Yang , Pandeswara Srilakshmi , Svatek Robert S. , Gelfond Jonathan A. , Liu Aijie , Hurez Vincent , Curiel Tyler J.
Published: April 2023

S1 shows DMBA/TPA modulation of epidermal alphabeta and gammadelta TCRhi T cells in WT and CXCR3-/- mice. S2 shows epidermal chemokines in WT and IFN-gamma-/- mice treated with Eudragit control or eRapa. S3 shows mTOR signaling in epidermal and draining lymph node T cells. S4 shows human gammadelta TCR expression in gammadelta T cells.
Supplemental Table 2 from SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2
Authors: Eytan Danielle F. , Snow Grace E. , Carlson Sophie , Derakhshan Adeeb , Saleh Anthony , Schiltz Stephen , Cheng Hui , Mohan Suresh , Cornelius Shaleeka , Coupar Jamie , Sowers Anastasia L. , Hernandez Lidia , Mitchell James B. , Annunziata Christina M. , Chen Zhong , Van Waes Carter
Published: April 2023

Birinapant IC50s
Supplementary Table S1 from p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis
Authors: Lam Hilaire C. , Baglini Christian V. , Lope Alicia Llorente , Parkhitko Andrey A. , Liu Heng-Jia , Alesi Nicola , Malinowska Izabela A. , Ebrahimi-Fakhari Darius , Saffari Afshin , Yu Jane J. , Pereira Ana , Khabibullin Damir , Ogorek Barbara , Nijmeh Julie , Kavanagh Taylor , Handen Adam , Chan Stephen Y. , Asara John M. , Oldham William M. , Diaz-Meco Maria T. , Moscat Jorge , Sahin Mustafa , Priolo Carmen , Henske Elizabeth P.
Published: April 2023

Metabolites significantly changed by p62 knockdown in Tsc2-/- MEFs
Suplementary Methods from SMAC Mimetic Birinapant plus Radiation Eradicates Human Head and Neck Cancers with Genomic Amplifications of Cell Death Genes FADD and BIRC2
Authors: Eytan Danielle F. , Snow Grace E. , Carlson Sophie , Derakhshan Adeeb , Saleh Anthony , Schiltz Stephen , Cheng Hui , Mohan Suresh , Cornelius Shaleeka , Coupar Jamie , Sowers Anastasia L. , Hernandez Lidia , Mitchell James B. , Annunziata Christina M. , Chen Zhong , Van Waes Carter
Published: April 2023

Supplementary Methods
Supplementary Table 4 from A Transcriptional Signature Identifies LKB1 Functional Status as a Novel Determinant of MEK Sensitivity in Lung Adenocarcinoma
Authors: Kaufman Jacob M. , Yamada Tadaaki , Park Kyungho , Timmers Cynthia D. , Amann Joseph M. , Carbone David P.
Published: April 2023

Regression associations between LKB1 loss signature and inhibitors in GDSC, CTRP, and CCLE studies
Supplementary Table 3 from A Transcriptional Signature Identifies LKB1 Functional Status as a Novel Determinant of MEK Sensitivity in Lung Adenocarcinoma
Authors: Kaufman Jacob M. , Yamada Tadaaki , Park Kyungho , Timmers Cynthia D. , Amann Joseph M. , Carbone David P.
Published: April 2023

Reported LKB1 mutations in cell lines
Figure S1 from p62/SQSTM1 Cooperates with Hyperactive mTORC1 to Regulate Glutathione Production, Maintain Mitochondrial Integrity, and Promote Tumorigenesis
Authors: Lam Hilaire C. , Baglini Christian V. , Lope Alicia Llorente , Parkhitko Andrey A. , Liu Heng-Jia , Alesi Nicola , Malinowska Izabela A. , Ebrahimi-Fakhari Darius , Saffari Afshin , Yu Jane J. , Pereira Ana , Khabibullin Damir , Ogorek Barbara , Nijmeh Julie , Kavanagh Taylor , Handen Adam , Chan Stephen Y. , Asara John M. , Oldham William M. , Diaz-Meco Maria T. , Moscat Jorge , Sahin Mustafa , Priolo Carmen , Henske Elizabeth P.
Published: April 2023

Transcript levels of amino acid transporters and enzymes regulating glutathione biosynthesis
Supplementary Figure Legends from Agonistic CD40 mAb-Driven IL12 Reverses Resistance to Anti-PD1 in a T-cell–Rich Tumor
Authors: Ngiow Shin Foong , Young Arabella , Blake Stephen J. , Hill Geoffrey R. , Yagita Hideo , Teng Michele W. L. , Korman Alan J. , Smyth Mark J.
Published: April 2023

Supplementary Figure Legends 1-5 combined
Figure S6 from INT6/EIF3E Controls the RNF8-Dependent Ubiquitylation Pathway and Facilitates DNA Double-Strand Break Repair in Human Cells
Authors: Morris Christelle , Tomimatsu Nozomi , Burma Sandeep , Jalinot Pierre
Published: April 2023

S6 shows how formation of K48- and K63-branched polyubiquitin chains at DNA damage foci are affected by silencing of INT6, RNF8 or VCP
Figure S1 from INT6/EIF3E Controls the RNF8-Dependent Ubiquitylation Pathway and Facilitates DNA Double-Strand Break Repair in Human Cells
Authors: Morris Christelle , Tomimatsu Nozomi , Burma Sandeep , Jalinot Pierre
Published: April 2023

S1 illustrates the defect of BRCA1 recruitment to DNA damage foci in INT6-silenced cells
Supplementary Figures 1 through 18 from CBX4 Suppresses Metastasis via Recruitment of HDAC3 to the Runx2 Promoter in Colorectal Carcinoma
Authors: Wang Xin , Li Liping , Wu Yuanzhong , Zhang Ruhua , Zhang Meifang , Liao Dan , Wang Gang , Qin Ge , Xu Rui-hua , Kang Tiebang
Published: April 2023

Supplemental Figure S1. The over-expression of CBX4, but not of other CBX members, suppresses the migration of DLD1 cells. Supplementary Figure S2. The knockdown of CBX4 enhances migration and invasion of CRC cells. Supplementary Figure S3. The over-expression of CBX4 inhibits the cell migration and invasion of CRC cells. Supplementary Figure S4. CBX4 represses the liver metastasis of HCT116 cells. Supplementary Figure S5. CBX4 is negatively related to the Runx2 expression in CRC cell lines. Supplementary Figure S6. The knockdown of Runx2 decreases the expression of Slug. Supplementary Figure S7. The promotion of cell migration and invasion after CBX4 knockdown primarily depends on Runx2. Supplementary Figure S8. The knockdown of Slug also reverses the promotion of cell migration and invasion after CBX4 knockdown. Supplementary Figure S9. IHC antibodies specifically recognized CBX4 or Runx2 protein. Supplementary Figure S10. The Î”SIM1/2 and CDM mutations marginally affect the functions of CBX4 in CRC. Supplementary Figure S11. CBX4 strongly binds with HDAC1, HDAC2, HDAC3 and HDAC9. Supplementary Figure S12. HDAC1, HDAC2, and HDAC3, but not HDAC9, are expressed in the tested CRC cell lines. Supplementary Figure S13. The Î”SIM1/2 and CDM mutations marginally affect the interaction of CBX4 with HDAC3. Supplementary Figure S14. The binding affinity of HDAC3 with the Runx2 promoter was dependent on CBX4. Supplementary Figure S15. The knockdown of HDAC3 abrogates the functions of CBX4 in CRC. Supplementary Figure S16. Determination of CBX4 fragments interacting with HDAC3. Supplementary Figure S17. The C-terminal 10 amino acids of CBX4 are responsible for its interaction with Bmi1. Supplementary Figure S18. The Î”DM1-CBX4 and Î”TM-CBX4 mutations, but not the deltaC-CBX4 mutation, abolish the inhibition of cell migration and invasion by CBX4.
Supplemental methods from Dietary Emulsifier–Induced Low-Grade Inflammation Promotes Colon Carcinogenesis
Authors: Viennois Emilie , Merlin Didier , Gewirtz Andrew T. , Chassaing Benoit
Published: April 2023

Detailed methods regarding the experiments performed and presented in the current study.
Supplementary Data S1 from CBX4 Suppresses Metastasis via Recruitment of HDAC3 to the Runx2 Promoter in Colorectal Carcinoma
Authors: Wang Xin , Li Liping , Wu Yuanzhong , Zhang Ruhua , Zhang Meifang , Liao Dan , Wang Gang , Qin Ge , Xu Rui-hua , Kang Tiebang
Published: April 2023

The transcriptome analysis of HCT116 cells transfected with scrambled or CBX4 shRNA.
Supplemental figures from Dietary Emulsifier–Induced Low-Grade Inflammation Promotes Colon Carcinogenesis
Authors: Viennois Emilie , Merlin Didier , Gewirtz Andrew T. , Chassaing Benoit
Published: April 2023

Figure S1: Schematic representation of the AOM-DSS experimental design. Figure S2: Dietary emulsifiers promote metabolic syndrome and low-grade intestinal inflammation in WT mice. Figure S3: Colonic histology analysis of emulsifiers promotion of colitis-associated cancer. Figure S4: Dietary emulsifiers induce alterations of the microbiota. Figure S5: Alpha diversity and summarized taxa of the fecal bacterial community following emulsifier treatment. Figure S6: Identification of bacterial members differentially expressed between experimental groups. Figure S7: Dietary emulsifiers favor a pro-inflammatory microbiota. Figure S8: Metagenome prediction analysis following CMC consumption. Figure S9: Metagenome prediction analysis following P80 consumption. Figure S10: Dietary emulsifiers alter epithelial cell proliferation and apoptosis during colitis-associated cancer development. Figure S11: Dietary emulsifier and AOM injection experiment.
Table S1: Primer sequence information from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer
Authors: Miao Lu , Yang Lin , Li Rui , Rodrigues Daniel N. , Crespo Mateus , Hsieh Jer-Tsong , Tilley Wayne D. , de Bono Johann , Selth Luke A. , Raj Ganesh V.
Published: April 2023

Primers sequence information for qPCR and ChIP-qPCR
Supplemental Figure 2 from Transcription Factor ZBP-89 Drives a Feedforward Loop of β-Catenin Expression in Colorectal Cancer
Authors: Essien Bryan E. , Sundaresan Sinju , Ocadiz-Ruiz Ramon , Chavis Aaron , Tsao Amy C. , Tessier Arthur J. , Hayes Michael M. , Photenhauer Amanda , Saqui-Salces Milena , Kang Anthony J. , Shah Yatrik M. , Győrffy Balazs , Merchant Juanita L.
Published: April 2023

Immunohistochemistry for ZBP-89 and Ki67 in WT and VC:Zfp148F/F mice
Figure S3: Effect of treatment protocol on Zeb1 protein expression from Disrupting Androgen Receptor Signaling Induces Snail-Mediated Epithelial–Mesenchymal Plasticity in Prostate Cancer
Authors: Miao Lu , Yang Lin , Li Rui , Rodrigues Daniel N. , Crespo Mateus , Hsieh Jer-Tsong , Tilley Wayne D. , de Bono Johann , Selth Luke A. , Raj Ganesh V.
Published: April 2023

C4-2 cells were subjected to the treatment protocol (Fig.1A). The mesenchymal marker Zeb1 expression was evaluated by Western Blotting