bluuebunny/crossref_metadata_2025 huggingface dataset:
Underground Pumped-Storage Hydropower (UPSH) at the Martelange Mine (Belgium): Interactions with Groundwater Flow
Authors: Pujades Estanislao , Orban Philippe , Archambeau Pierre , Kitsikoudis Vasileios , Erpicum Sebastien , Dassargues Alain
Published: May 2020

Underground pumped-storage hydropower (UPSH) is a promising technology to manage the electricity production in flat regions. UPSH plants consist of an underground and surface reservoirs. The energy is stored by pumping water from the underground to the surface reservoir and is produced by discharging water from the surface to the underground reservoir. The underground reservoir can be drilled, but a more efficient alternative, considered here, consists in using an abandoned mine. Given that mines are rarely waterproofed, there are concerns about the consequences (on the efficiency and the environment) of water exchanges between the underground reservoir and the surrounding medium. This work investigates numerically such water exchanges and their consequences. Numerical models are based on a real abandoned mine located in Belgium (Martelange slate mine) that is considered as a potential site to construct an UPSH plant. The model integrates the geometrical complexity of the mine, adopts an operation scenario based on actual electricity prices, simulates the behavior of the system during one year and considers two realistic scenarios of initial conditions with the underground reservoir being either completely full or totally drained. The results show that (1) water exchanges may have important consequences in terms of efficiency and environmental impacts, (2) the influence of the initial conditions is only relevant during early times, and (3), an important factor controlling the water exchanges and their consequences may be the relative location of the natural piezometric head with respect the underground reservoir.
Influence of Sulfate Ions on the Combined Application of Modified Water and Polymer Flooding—Rheology and Oil Recovery
Authors: Tahir Muhammad , Hincapie Rafael E. , Ganzer Leonhard
Published: May 2020

Oil recovery using modified/smart water technology can be maximized by optimizing the composition of the injected water. Brine optimization is also believed to improve polymer flooding performance. This chapter assesses and defines the potential impact of combining low-salt-modified water with polymer flooding, based on the presence of sulfate in the injection water. Hence, we evaluated the influence of sodium sulfate on (1) polymer viscoelasticity, under the assumption that the phenomena exists, and (2) oil recovery and pressure response. Mainly, a comprehensive rheological evaluation and two-phase core flood experiments are the focus of this work. Composition of injection brine is optimized after having synthetic seawater as a base brine. Core-flood experiments were performed in a secondary, tertiary and a sort of post-tertiary (quaternary) mode to evaluate the feasibility of applying both processes (modified water and polymer flood). Obtained data was subsequently cross-analyzed and as an overall observation, sodium sulfate helped with improving polymer viscosity compared to sodium chloride or divalent cation presence. Moreover, optimized modified water, with the higher amount of sulfate ions, showed an additional oil recovery in both secondary and tertiary mode of about 5.0%. Additionally, polymer injection in tertiary mode, after modified-water injection, showed significant additional oil recovery.
Progress in Modeling and Control of Gas Turbine Power Generation Systems: A Survey
Authors: Mohamed Omar , Khalil Ashraf
Published: May 2020

This paper reviews the modeling techniques and control strategies applied to gas turbine power generation plants. Recent modeling philosophies are discussed and the state-of-the-art feasible strategies for control are shown. Research conducted in the field of modeling, simulation, and control of gas turbine power plants has led to notable advancements in gas turbines’ operation and energy efficiency. Tracking recent achievements and trends that have been made is essential for further development and future research. A comprehensive survey is presented here that covers the outdated attempts toward the up-to-date techniques with emphasis on different issues and turbines’ characteristics. Critical review of the various published methodologies is very useful in showing the importance of this research area in practical and technical terms. The different modeling approaches are classified and each category is individually investigated by reviewing a considerable number of research articles. Then, the main features of each category or approach is reported. The modern multi-variable control strategies that have been published for gas turbines are also reviewed. Moreover, future trends are proposed as recommendations for planned research.
The Right to A Clean Environment: Considering Green Logistics and Sustainable Tourism
Authors: Perkumienė Dalia , Pranskūnienė Rasa , Vienažindienė Milita , Grigienė Jurgita
Published: May 2020

The globalization process has yielded various undesirable consequences for the environment and society, including increased environmental pollution, climate change and the exhaustion and destruction of resources. The influence of these processes makes it difficult to guarantee citizens’ rights to a clean environment, and the implementation of this right requires complex solutions. The aim of this integrative review article is to discuss the right to a clean environment, as it relates to green logistics and sustainable tourism, by analyzing various scientific and legal sources. Rethinking the possible solutions of green logistics for sustainable tourism, such as tourism mobilities, bicycle tourism, the co-creation of smart velomobility, walkability, and others, can help us also rethink how to balance, respect, protect, and enforce human rights in the present-day context of climate change challenges. The integrative review analysis shows the importance of seeking a balance between the context (the right to a clean environment), the challenge (climate change), and the solutions (green logistics solutions for sustainable tourism).
Assessing the Social Value of Ecosystem Services for Resilient Riparian Greenway Planning and Management in an Urban Community
Authors: Lee Junga , Kweon Byoung-Suk , Ellis Christopher D. , Lee Sang-Woo
Published: May 2020

Ecosystem services depend on the interrelation between people and the environment, and people are increasingly recognizing the social value of ecosystem services. Based on humans needs related to the values of ecosystem services, riparian greenways, properly planned and managed for resiliency, could provide great opportunities for social ecological change and transformation toward sustainability. We focus on the ecosystem service values of such greenways based on resilience in urban communities. The purpose of this study is to assess the social value of ecosystem services for resilient riparian greenway planning and management based on a survey of residents living near the Yangjaecheon riparian greenway in Gwacheon, South Korea. First, cluster analysis was performed with data from 485 completed surveys to identify different groups of respondents. Importance-performance analysis (IPA) was then applied to develop planning and management guidance for the riparian greenway based on group characteristics. Two distinct groups were identified: the Strong Social Value of Ecosystem Services group and the Neutral Social Value of Ecosystem Services group. Different distributions were found between the two groups based on gender and residency period, and significant differences were also found for age and familiarity with the riparian greenway. The results show what each group perceived to be important and how well the riparian greenway met their expectations regarding ecosystem services. These results indicate the perceived value of ecosystem services on the basis of the group characteristics, helping establish the direction for resilient riparian greenway planning and management approaches.
Measures to Promote Rural Healthcare Tourism with a Scientific Evidence-Based Approach
Authors: Joung Dawou , Lee Bohwi , Lee Jeongdo , Lee Changjun , Koo Seungmo , Park Changwon , Kim Sebin , Kagawa Takahide , Park Bum-Jin
Published: May 2020

The present study aimed to evaluate the effects of physical activities on human health in forests in countryside and rural areas. The test experiment was conducted in a countryside forest, whereas the controlled experiment was conducted in an urban area where the study participants resided. A total of 22 participants (aged 20.9 ± 1.3 years) were evaluated in this study. Heart rate variability and salivary cortisol level were used as indices of physiological conditions, and semantic differential method, profile of mood states (POMS), and state-trait anxiety inventory (STAI) were used to evaluate the participants’ emotional states. The participants were asked to walk around forest and urban areas for 15 min. The results were as follows. As compared to the urban area, in the forest area, (1) the power of the high-frequency (HF) component of the heart rate variability (HRV) was significantly higher; (2) low-frequency (LF)/(LF + HF) was significantly lower; (3) salivary cortisol level was significantly lower; (4) the participants felt more comfortable, natural, relaxed, and less anxious and showed higher levels of positive emotions and lower levels of negative emotions. Consequently, walking in the forest area induces relaxing short-term physiological and psychological effects on young people living in urban areas.
Effects of Different Graphic Health Warning Types on the Intention to Quit Smoking
Authors: Park Hyejin , Hong Min-Young , Lee In-Seon , Chae Younbyoung
Published: May 2020

Anti-smoking advertisements are widely used to demonstrate to smokers the harm of smoking, and graphic health warnings (GHWs) are expected to have a positive effect on the intention to quit smoking. This study investigated which type of GHW (health-related threat (H-GHW) vs. social threat (S-GHW)) is more effective. Two types of GHWs for tobacco were shown to 28 daily smokers and 25 non-smokers while measuring their eye movements using an eye tracker. The time spent fixating on the GHWs was measured as an index of attentional bias. Participants were also asked to evaluate the unpleasantness of the images. They stated their intention to quit smoking in response to each image in a separate session. Multiple regression analysis was used to identify the effects of psychosocial factors on the intention to quit smoking in smokers and the intention to remain as non-smokers in the non-smokers. Both smokers and non-smokers reported greater unpleasantness and cessation intentions in response to H-GHWs than to S-GHWs. Non-smokers found both types of GHWs more unpleasant than smokers did. No differences were found in gaze fixation on GHWs between the two groups. When smokers viewed S-GHWs, the intention to quit smoking was greater as they felt more unpleasant. For non-smokers, the intention to remain non-smokers was greater when they felt more unpleasant and when the attention to H-GHWs was lower. Different psychological factors in anti-smoking advertisements are involved in the intention to quit smoking in smokers and to maintain a non-smoking status in non-smokers. Different approaches should be used according to the types of warning (e.g., warnings emphasizing a negative influence on others or on their own health) in anti-smoking campaigns.
Physical Activity Habits and Determinants, Sedentary Behaviour and Lifestyle in University Students
Authors: Carballo-Fazanes Aida , Rico-Díaz Javier , Barcala-Furelos Roberto , Rey Ezequiel , Rodríguez-Fernández José E. , Varela-Casal Cristina , Abelairas-Gómez Cristian
Published: May 2020

University students, as a result of their lifestyles, represent a section of the population that is most likely to adopt sedentary behaviours. The aim of the present study was to analyse the determining factors dictating the performance of physical activity as well as sedentary behaviour among university students. A total of 608 students (64.6% women) from the University of Santiago de Compostela (Spain) were selected by stratified random sampling to take part in the study, which involved completing a questionnaire on lifestyle and physical activity. Of the participating students, 69.6% indicated that they performed physical activity; the main reasons given were to maintain fitness and for health, while a lack of time and laziness were the principal reasons given for abandoning or not taking up physical exercise. Significant associations were established between not doing physical activity and the time exposed to screens, time studying, feeling low and smoking; on the other hand, associations could be seen between doing physical activity and the participation of relatives (parents, mothers, partners, older siblings and friends) in physical activity, as well as a positive sense of satisfaction relating to physical education taught in schools. In conclusion, most of the university students did some physical activity, which was associated with less sedentary behaviour, while the influence of school physical education and of the habits of relatives played an important role.
Root Cause Analysis to Identify Medication and Non-Medication Strategies to Prevent Infection-Related Hospitalizations from Australian Residential Aged Care Services
Authors: Sluggett Janet K. , Lalic Samanta , Hosking Sarah M. , Ritchie Brett , McLoughlin Jennifer , Shortt Terry , Robson Leonie , Cooper Tina , Cairns Kelly A. , Ilomäki Jenni , Visvanathan Renuka , Bell J. Simon
Published: May 2020

Infections are leading causes of hospitalizations from residential aged care services (RACS), which provide supported accommodation for people with care needs that can no longer be met at home. Preventing infections and early and effective management are important to avoid unnecessary hospital transfers, particularly in the Australian setting where new quality standards require RACS to minimize infection-related risks. The objective of this study was to examine root causes of infection-related hospitalizations from RACS and identify strategies to limit infections and avoid unnecessary hospitalizations. An aggregate root cause analysis (RCA) was undertaken using a structured local framework. A clinical nurse auditor and clinical pharmacist undertook a comprehensive review of 49 consecutive infection-related hospitalizations from 6 RACS. Data were collected from nursing progress notes, medical records, medication charts, hospital summaries, and incident reports using a purpose-built collection tool. The research team then utilized a structured classification system to guide the identification of root causes of hospital transfers. A multidisciplinary clinical panel assessed the root causes and formulated strategies to limit infections and hospitalizations. Overall, 59.2% of hospitalizations were for respiratory, 28.6% for urinary, and 10.2% for skin infections. Potential root causes of infections included medications that may increase infection risk and resident vaccination status. Potential contributors to hospital transfers included possible suboptimal selection of empirical antimicrobial therapy, inability of RACS staff to establish on-site intravenous access for antimicrobial administration, and the need to access subsidized medical services not provided in the RACS (e.g., radiology and pathology). Strategies identified by the panel included medication review, targeted bundles of care, additional antimicrobial stewardship initiatives, earlier identification of infection, and models of care that facilitate timely access to medical services. The RCA and clinical panel findings provide a roadmap to assist targeting services to prevent infection and limit unnecessary hospital transfers from RACS.
Multisensorial Close-Range Sensing Generates Benefits for Characterization of Managed Scots Pine (Pinus sylvestris L.) Stands
Authors: Yrttimaa Tuomas , Saarinen Ninni , Kankare Ville , Viljanen Niko , Hynynen Jari , Huuskonen Saija , Holopainen Markus , Hyyppä Juha , Honkavaara Eija , Vastaranta Mikko
Published: May 2020

Terrestrial laser scanning (TLS) provides a detailed three-dimensional representation of surrounding forest structures. However, due to close-range hemispherical scanning geometry, the ability of TLS technique to comprehensively characterize all trees, and especially upper parts of forest canopy, is often limited. In this study, we investigated how much forest characterization capacity can be improved in managed Scots pine (Pinus sylvestris L.) stands if TLS point clouds are complemented with photogrammetric point clouds acquired from above the canopy using unmanned aerial vehicle (UAV). In this multisensorial (TLS+UAV) close-range sensing approach, the used UAV point cloud data were considered especially suitable for characterizing the vertical forest structure and improvements were obtained in estimation accuracy of tree height as well as plot-level basal-area weighted mean height (Hg) and mean stem volume (Vmean). Most notably, the root-mean-square-error (RMSE) in Hg improved from 0.8 to 0.58 m and the bias improved from −0.75 to −0.45 m with the multisensorial close-range sensing approach. However, in managed Scots pine stands, the mere TLS also captured the upper parts of the forest canopy rather well. Both approaches were capable of deriving stem number, basal area, Vmean, Hg, and basal area-weighted mean diameter with the relative RMSE less than 5.5% for all the sample plots. Although the multisensorial close-range sensing approach mainly enhanced the characterization of the forest vertical structure in single-species, single-layer forest conditions, representation of more complex forest structures may benefit more from point clouds collected with sensors of different measurement geometries.
Spatially Supported Disaster Management: Introduction to the Special Issue “GI for Disaster Management”
Authors: Altan Orhan , Tanzi Tullio Joseph , Chandra Madhu , Sunar Filiz , Halounová Lena
Published: May 2020

This special issue explores most of the scientific issues related to spatially supported disaster management and its integration with geographical information system technologies in different disaster examples and scales [...]
IL-4 and SDF-1 Increase Adipose Tissue-Derived Stromal Cell Ability to Improve Rat Skeletal Muscle Regeneration
Authors: Zimowska Małgorzata , Archacka Karolina , Brzoska Edyta , Bem Joanna , Czerwinska Areta M. , Grabowska Iwona , Kasprzycka Paulina , Michalczewska Emilia , Stepaniec Igor , Soszynska Marta , Ilach Katarzyna , Streminska Wladyslawa , Ciemerych Maria A.
Published: May 2020

Skeletal muscle regeneration depends on the satellite cells, which, in response to injury, activate, proliferate, and reconstruct damaged tissue. However, under certain conditions, such as large injuries or myopathies, these cells might not sufficiently support repair. Thus, other cell populations, among them adipose tissue-derived stromal cells (ADSCs), are tested as a tool to improve regeneration. Importantly, the pro-regenerative action of such cells could be improved by various factors. In the current study, we tested whether IL-4 and SDF-1 could improve the ability of ADSCs to support the regeneration of rat skeletal muscles. We compared their effect at properly regenerating fast-twitch EDL and poorly regenerating slow-twitch soleus. To this end, ADSCs subjected to IL-4 and SDF-1 were analyzed in vitro and also in vivo after their transplantation into injured muscles. We tested their proliferation rate, migration, expression of stem cell markers and myogenic factors, their ability to fuse with myoblasts, as well as their impact on the mass, structure and function of regenerating muscles. As a result, we showed that cytokine-pretreated ADSCs had a beneficial effect in the regeneration process. Their presence resulted in improved muscle structure and function, as well as decreased fibrosis development and a modulated immune response.
Niacin Alleviates Dairy Cow Mastitis by Regulating the GPR109A/AMPK/NRF2 Signaling Pathway
Authors: Guo Wenjin , Liu Juxiong , Li Wen , Ma He , Gong Qian , Kan Xingchi , Cao Yu , Wang Jianfa , Fu Shoupeng
Published: May 2020

Mastitis is one of three bovine diseases recognized as a cause of substantial economic losses every year throughout the world. Niacin is an important feed additive that is used extensively for dairy cow nutrition. However, the mechanism by which niacin acts on mastitis is not clear. The aim of this study is to investigate the mechanism of niacin in alleviating the inflammatory response of mammary epithelial cells and in anti-mastitis. Mammary glands, milk, and blood samples were collected from mastitis cows not treated with niacin (n = 3) and treated with niacin (30 g/d, n = 3) and healthy cows (n = 3). The expression of GPR109A, IL-6, IL-1β, and TNF-α in the mammary glands of the dairy cows with mastitis was significantly higher than it was in the glands of the healthy dairy cows. We also conducted animal experiments in vivo by feeding rumen-bypassed niacin. Compared with those in the untreated mastitis group, the somatic cell counts (SCCs) and the expression of IL-6, IL-1β, and TNF-α in the blood and milk were lower. In vitro, we isolated the primary bovine mammary epithelial cells (BMECs) from the mammary glands of the healthy cows. The mRNA levels of IL-6, IL-1β, TNF-α, and autophagy-related genes were detected after adding niacin, shRNA, compound C, trans retinoic acid, 3-methyladenine to BMECs. Then GPR109A, AMPK, NRF-2, and autophagy-related proteins were detected by Western blot. We found that niacin can activate GPR109A and phosphorylate AMPK, and promote NRF-2 nuclear import and autophagy to alleviate LPS-induced inflammatory response in BMECs. In summary, we found that niacin can reduce the inflammatory response of BMECs through GPR109A/AMPK/NRF-2/autophagy. We also preliminarily explored the alleviative effect of niacin on mastitis in dairy cows.
Kandelia candel Thioredoxin f Confers Osmotic Stress Tolerance in Transgenic Tobacco
Authors: Jing Xiaoshu , Yao Jun , Ma Xujun , Zhang Yanli , Sun Yuanling , Xiang Min , Hou Peichen , Li Niya , Zhao Rui , Li Jinke , Zhou Xiaoyang , Chen Shaoliang
Published: May 2020

Water deficit caused by osmotic stress and drought limits crop yield and tree growth worldwide. Screening and identifying candidate genes from stress-resistant species are a genetic engineering strategy to increase drought resistance. In this study, an increased concentration of mannitol resulted in elevated expression of thioredoxin f (KcTrxf) in the nonsecretor mangrove species Kandelia candel. By means of amino acid sequence and phylogenetic analysis, the mangrove Trx was classified as an f-type thioredoxin. Subcellular localization showed that KcTrxf localizes to chloroplasts. Enzymatic activity characterization revealed that KcTrxf recombinant protein possesses the disulfide reductase function. KcTrxf overexpression contributes to osmotic and drought tolerance in tobacco in terms of fresh weight, root length, malondialdehyde (MDA) content, and hydrogen peroxide (H2O2) production. KcTrxf was shown to reduce the stomatal aperture by enhancing K+ efflux in guard cells, which increased the water-retaining capacity in leaves under drought conditions. Notably, the abscisic acid (ABA) sensitivity was increased in KcTrxf-transgenic tobacco, which benefits plants exposed to drought by reducing water loss by promoting stomatal closure. KcTrxf-transgenic plants limited drought-induced H2O2 in leaves, which could reduce lipid peroxidation and retain the membrane integrity. Additionally, glutathione (GSH) contributing to reactive oxygen species (ROS) scavenging and transgenic plants are more efficient at regenerating GSH from oxidized glutathione (GSSG) under conditions of drought stress. Notably, KcTrxf-transgenic plants had increased glucose and fructose contents under drought stress conditions, presumably resulting from KcTrxf-promoted starch degradation under water stress. We conclude that KcTrxf contributes to drought tolerance by increasing the water status, by enhancing osmotic adjustment, and by maintaining ROS homeostasis in transgene plants.
Therapeutic Effect of Rapamycin on Aortic Dissection in Mice
Authors: Hayashi-Hori Makiko , Aoki Hiroki , Matsukuma Miho , Majima Ryohei , Hashimoto Yohei , Ito Sohei , Hirakata Saki , Nishida Norifumi , Furusho Aya , Ohno-Urabe Satoko , Fukumoto Yoshihiro
Published: May 2020

Aortic dissection (AD) is a serious clinical condition that is unpredictable and frequently results in fatal outcome. Although rapamycin, an inhibitor of mechanistic target of rapamycin (mTOR), has been reported to be effective in preventing aortopathies in mouse models, its mode of action has yet to be clarified. A mouse AD model that was created by the simultaneous administration of β-aminopropionitrile (BAPN) and angiotensin II (AngII) for 14 days. Rapamycin treatment was started either at day 1 or at day 7 of BAPN+AngII challenge, and continued throughout the observational period. Rapamycin was effective both in preventing AD development and in suppressing AD progression. On the other hand, gefitinib, an inhibitor of growth factor signaling, did not show such a beneficial effect, even though both rapamycin and gefitinib suppressed cell cycle activation in AD. Rapamycin suppressed cell cycle-related genes and induced muscle development-related genes in an AD-related gene expression network without a major impact on inflammation-related genes. Rapamycin augmented the activation of Akt1, Akt2, and Stat3, and maintained the contractile phenotype of aortic smooth muscle cells. These findings indicate that rapamycin was effective both in preventing the development and in suppressing the progression of AD, indicating the importance of the mTOR pathway in AD pathogenesis.
Clinical Utility of Extracorporeal Shock Wave Therapy on Hypertrophic Scars of the Hand Caused by Burn Injury: A Prospective, Randomized, Double-Blinded Study
Authors: Joo So Young , Lee Seung Yeol , Cho Yoon Soo , Seo Cheong Hoon
Published: May 2020

Postburn hypertrophic scarring is a common complication in burn injuries to the hands, often associated with impaired hand function. We evaluated the effects of extracorporeal shock wave therapy (ESWT), compared to a sham stimulation therapy, on hypertrophic scars of the hand caused by burn injury and investigated its effects on hand function. This was a double-blinded, randomized, controlled trial of 48 patients with a burn to their dominant right hand. The parameters of ESWT were as follows: energy flux density, 0.05–0.30 mJ/mm2; frequency, 4 Hz; 1000 to 2000 impulses per treatment; four treatments, once a week for four weeks. The outcomes measured were as follows: a 10-point visual analogue scale pain score; Vancouver scar scale for scar vascularity, height, pliability and pigmentation; ultrasound measurement of scar thickness; Jebsen−Taylor hand function test; grip strength; Perdue pegboard test; and the Michigan hand outcomes questionnaire. The change in the score from baseline to post-treatment was compared between the two groups. ESWT improved the pain score (p = 0.001), scar thickness (p = 0.018), scar vascularity (p = 0.0015), and improved hand function (simulated card-turning, p = 0.02; picking up small objects, p = 0.004). The other measured outcomes were not different between the two groups. ESWT is effective in decreasing pain, suppressing hypertrophic scarring, and improving hand function.
Treatment of Hodgkin Lymphoma Relapsed after Autologous Stem Cell Transplantation
Authors: Domingo-Domènech Eva , Sureda Anna
Published: May 2020

Although autologous stem cell transplantation (auto-HCT) is the standard of care for patients with refractory/relapsed (R/R) classical Hodgkin’s lymphoma (cHL), there is still a significant proportion of patients that relapse after the procedure. This review contemplates different treatment strategies for patients with cHL that relapse or progress after auto-HCT. Allogeneic stem cell transplantation (allo-HCT) has, for many years, been the only curative option for this group of patients. Although the advent of haploidentical donors has allowed for the possibility to allograft almost all patients that are in need of it and to eventually improve historical results, allo-HCT is still associated with substantial morbidity and mortality. Brentuximab vedotin (BV) is an antibody drug conjugate that binds to CD30 antigen; BV is able to give up to 34% metabolic complete remissions (mCR) in HL patients that fail auto-HCT. Unleashing the immune system with PD-1 inhibitors has resulted in remarkable responses in a number of malignancies, including HL. Nivolumab and pembrolizumab offer a 20%–25% mCR and 40%–50% partial remissions, with an acceptable safety profile. R/R cHL do have several options nowadays that, without any doubt, have significantly improved the long-term outcome of this hard-to-treat population.
Metabolic Tumour Volume from PSMA PET/CT Scans of Prostate Cancer Patients during Chemotherapy—Do Different Software Solutions Deliver Comparable Results?
Authors: Hartrampf Philipp E. , Heinrich Marieke , Seitz Anna Katharina , Brumberg Joachim , Sokolakis Ioannis , Kalogirou Charis , Schirbel Andreas , Kübler Hubert , Buck Andreas K. , Lapa Constantin , Krebs Markus
Published: May 2020

(1) Background: Prostate-specific membrane antigen (PSMA)-derived tumour volume (PSMA-TV) and total lesion PSMA (TL-PSMA) from PSMA PET/CT scans are promising biomarkers for assessing treatment response in prostate cancer (PCa). Currently, it is unclear whether different software tools for assessing PSMA-TV and TL-PSMA produce comparable results. (2) Methods: 68Ga-PSMA PET/CT scans from n = 21 patients with castration-resistant PCa (CRPC) receiving chemotherapy were identified from our single-centre database. PSMA-TV and TL-PSMA were calculated with Syngo.via (Siemens) as well as the freely available Beth Israel plugin for FIJI (Fiji Is Just ImageJ) before and after chemotherapy. While statistical comparability was illustrated and quantified via Bland-Altman diagrams, the clinical agreement was estimated by matching PSMA-TV, TL-PSMA and relative changes of both variables during chemotherapy with changes in serum PSA (ΔPSA) and PERCIST (Positron Emission Response Criteria in Solid Tumors). (3) Results: Comparing absolute PSMA-TV and TL-PSMA as well as Bland–Altman plotting revealed a good statistical comparability of both software algorithms. For clinical agreement, classifying therapy response did not differ between PSMA-TV and TL-PSMA for both software solutions and showed highly positive correlations with BR. (4) Conclusions: due to the high levels of statistical and clinical agreement in our CRPC patient cohort undergoing taxane chemotherapy, comparing PSMA-TV and TL-PSMA determined by Syngo.via and FIJI appears feasible.
Causes and Treatment Measures of Submarine Pipeline Free-Spanning
Authors: Zhang Bo , Gong Rui , Wang Tao , Wang Zhuo
Published: May 2020

Submarine pipelines, as arteries for offshore oil and gas transportation, play a particularly important role in the exploitation of offshore oil and gas resources. Since the world’s first submarine pipelines were laid in the Gulf of Mexico, numerous failures have been caused by pipeline free-spanning. This paper provides a review of the causes and treatment measures for the free span of submarine pipeline. Various factors cause the free span of submarine pipelines, including wave flow scouring, fluctuations in seabed topography, residual stress or thermal stress of pipelines, and human activities. The scour of the wave current is the main factor affecting free span; the research on sediment starting and equilibrium depth during scour is reviewed in-depth. For the span treatment of submarine pipelines, the main measures available at present include the re-digging trench burying, structural support, covering bionic water plants, and choke plate self-burying. For each, the principle, advantages, disadvantages, and research are discussed. This review provides a convenient resource for understanding the causes of submarine free-spanning pipelines and choosing suitable treatment measures.
An Investigation of the Ship Safety Distance for Bridges across Waterways Based on Traffic Distribution
Authors: Son Woo-Ju , Lee Jeong-Seok , Lee Hyeong-Tak , Cho Ik-Soon
Published: May 2020

For ship passage safety, a bridge across a waterway is a risk for accidents. However, no standard for the safe distance between a bridge and a ship is available in Korea. The UK MCA considers the 90% confidence interval of traffic distribution as the acceptable passage range, using it for measuring the separation between offshore wind farms. In this study, an optimal ship safety distance is proposed by evaluating traffic distribution at the Incheon and Busan harbor bridges and analyzing the confidence intervals. The results, based on the Z-score, reveal that at the Incheon bridge, all but one ship for 2-way departure were in circulation within the 95% confidence interval range, whereas at the Busan harbor bridge, six ships for arrival and two ships for departure were outside the 95% range. Based on the results of this study, the design of bridges across waterways can incorporate traffic distribution corresponding to each port.
A Model for Determining Weight Coefficients by Forming a Non-Decreasing Series at Criteria Significance Levels (NDSL)
Authors: Žižović Mališa , Pamučar Dragan , Ćirović Goran , Žižović Miodrag M. , Miljković Boža D.
Published: May 2020

In this paper, a new method for determining weight coefficients by forming a non-decreasing series at criteria significance levels (the NDSL method) is presented. The NDLS method includes the identification of the best criterion (i.e., the most significant and most influential criterion) and the ranking of criteria in a decreasing series from the most significant to the least significant criterion. Criteria are then grouped as per the levels of significance within the framework of which experts express their preferences in compliance with the significance of such criteria. By employing this procedure, fully consistent results are obtained. In this paper, the advantages of the NDSL model are singled out through a comparison with the Best Worst Method (BWM) and Analytic Hierarchy Process (AHP) models. The advantages include the following: (1) the NDSL model requires a significantly smaller number of pairwise comparisons of criteria, only involving an n − 1 comparison, whereas the AHP requires an n(n − 1)/2 comparison and the BWM a 2n − 3 comparison; (2) it enables us to obtain reliable (consistent) results, even in the case of a larger number of criteria (more than nine criteria); (3) the NDSL model applies an original algorithm for grouping criteria according to the levels of significance, through which the deficiencies of the 9-degree scale applied in the BWM and AHP models are eliminated. By doing so, the small range and inconsistency of the 9-degree scale are eliminated; (4) while the BWM includes the defining of one unique best/worst criterion, the NDSL model eliminates this limitation and gives decision-makers the freedom to express the relationships between criteria in accordance with their preferences. In order to demonstrate the performance of the developed model, it was tested on a real-world problem and the results were validated through a comparison with the BWM and AHP models.
Resolution of Fetal Hydrops Dependent on Sustained Fetal Supraventricular Tachycardia after Digoxin Therapy
Authors: Maciuleviciute Aureja , Semenaite Migle , Gintautas Vladas , Maciuleviciene Regina , Puodziukynas Aras , Savukyne Egle
Published: May 2020

We present a special case of fetal supraventricular tachycardia detected at 34 weeks gestation. Fetal hydrops was noted on ultrasound upon admission. Normal fetal heart rate was maintained for three weeks by maternal administration of digoxin. A live infant was delivered via caesarian section at 37 weeks gestation. This clinical case demonstrated that pharmacological treatment can be effective and helps to prolong pregnancy safely.
Metabolite Changes during Postharvest Storage: Effects on Fruit Quality Traits
Authors: Pott Delphine M. , Vallarino José G. , Osorio Sonia
Published: May 2020

Metabolic changes occurring in ripe or senescent fruits during postharvest storage lead to a general deterioration in quality attributes, including decreased flavor and ‘off-aroma’ compound generation. As a consequence, measures to reduce economic losses have to be taken by the fruit industry and have mostly consisted of storage at cold temperatures and the use of controlled atmospheres or ripening inhibitors. However, the biochemical pathways and molecular mechanisms underlying fruit senescence in commercial storage conditions are still poorly understood. In this sense, metabolomic platforms, enabling the profiling of key metabolites responsible for organoleptic and health-promoting traits, such as volatiles, sugars, acids, polyphenols and carotenoids, can be a powerful tool for further understanding the biochemical basis of postharvest physiology and have the potential to play a critical role in the identification of the pathways affected by fruit senescence. Here, we provide an overview of the metabolic changes during postharvest storage, with special attention to key metabolites related to fruit quality. The potential use of metabolomic approaches to yield metabolic markers useful for chemical phenotyping or even storage and marketing decisions is highlighted.
Spinasterol, 22,23-Dihydrospinasterol and Fernenol from Citrullus Colocynthis L. with Aphicidal Activity against Cabbage Aphid Brevicoryne Brassicae L.
Authors: Ahmed Maqsood , Qin Peiwen , Ji Mingshan , An Ran , Guo Hongxia , Shafi Jamil
Published: May 2020

Brevicoryne brassicae is a problematic pest in cabbage and other field crops. Synthetic pesticides are used to control this pest, but they are injurious for human health and the environment. The present study aimed to purify and identify the active compounds from Citrullus colocynthis leaves with an appraisal of their efficacy against B. brassicae. Separation and purification were performed via different chromatographic techniques. Molecular analysis and chemical structures were recognized by mass spectrum (MS) and nuclear magnetic resonance (NMR), respectively. Moreover, in vitro and in vivo aphicidal activity was assessed using various concentrations, i.e., 6.25, 12.5, 25 and 50 µg/mL at 12, 24, 48 and 72 h exposure. The outcome shows that mass spectrum analyses of the purified compounds suggested the molecular formulae are C30H50O and C29H50O, C29H48O. The compounds were characterized as fernenol and a mixture of spinasterol, 22,23-dihydrospinasterol by 1H-NMR and 13C-NMR spectrum analysis. The toxicity results showed that the mixture of spinasterol and 22,23-dihydrospinasterol showed LC50 values of 32.36, 44.49 and 37.50 µg/mL by contact, residual and greenhouse assay at 72 h exposure, respectively. In contrast, fernenol recorded LC50 values as 47.99, 57.46 and 58.67 µg/mL, respectively. On the other hand, spinasterol, 22,23-dihydrospinasterol showed the highest mortality, i.e., 66.67%, 53.33% and 60% while, 30%, 23.33% and 25% mortality was recorded by fernenol after 72 h at 50 µg/mL by contact, residual and greenhouse assay, respectively. This study suggests that spinasterol, 22,23-dihydrospinasterol are more effective against B. brassicae which may be introduced as an effective and suitable substitute of synthetic chemical pesticides.
The Role of Hormones and Trophic Factors as Components of Preservation Solutions in Protection of Renal Function before Transplantation: A Review of the Literature
Authors: Ostróżka-Cieślik Aneta , Dolińska Barbara
Published: May 2020

Transplantation is currently a routine method for treating end-stage organ failure. In recent years, there has been some progress in the development of an optimal composition of organ preservation solutions, improving the vital functions of the organ and allowing to extend its storage period until implantation into the recipient. Optimizations are mostly based on commercial solutions, routinely used to store grafts intended for transplantation. The paper reviews hormones with a potential nephroprotective effect, which were used to modify the composition of renal perfusion and preservation solutions. Their effectiveness as ingredients of preservation solutions was analysed based on a literature review. Hormones and trophic factors are innovative preservation solution supplements. They have a pleiotropic effect and affect normal renal function. The expression of receptors for melatonin, prolactin, thyrotropin, corticotropin, prostaglandin E1 and trophic factors was confirmed in the kidneys, which suggests that they are a promising therapeutic target for renal IR (ischemia-reperfusion) injury. They can have anti-inflammatory, antioxidant and anti-apoptotic effects, limiting IR injury.
A Heterometallic Three-Dimensional Metal−Organic Framework Bearing an Unprecedented One-Dimensional Branched-Chain Secondary Building Unit
Authors: Chen Jing , Chao Meng-Yao , Liu Yan , Xu Bo-Wei , Zhang Wen-Hua , Young David J.
Published: May 2020

A heterometallic metal−organic framework (MOF) of [Cd6Ca4(BTB)6(HCOO)2(DEF)2(H2O)12]∙DEF∙xSol (1, H3BTB = benzene-1,3,5-tribenzoic acid; DEF = N,N′-diethylformamide; xSol. = undefined solvates within the pore) was prepared by solvothermal reaction of Cd(NO3)2·4H2O, CaO and H3BTB in a mixed solvent of DEF/H2O/HNO3. The compatibility of these two divalent cations from different blocks of the periodic table results in a solid-state structure consisting of an unusual combination of a discrete V-shaped heptanuclear cluster of [Cd2Ca]2Ca′ and an infinite one-dimensional (1D) chain of [Cd2CaCa′]n that are orthogonally linked via a corner-shared Ca2+ ion (denoted as Ca′), giving rise to an unprecedented branched-chain secondary building unit (SBU). These SBUs propagate via tridentate BTB to yield a three-dimensional (3D) structure featuring a corner-truncated P41 helix in MOF 1. This outcome highlights the unique topologies possible via the combination of carefully chosen s- and d-block metal ions with polydentate ligands.
Δ1-Dehydrogenation and C20 Reduction of Cortisone and Hydrocortisone Catalyzed by Rhodococcus Strains
Authors: Costa Stefania , Zappaterra Federico , Summa Daniela , Semeraro Bruno , Fantin Giancarlo
Published: May 2020

Prednisone and prednisolone are steroids widely used as anti-inflammatory drugs. Development of the pharmaceutical industry is currently aimed at introducing biotechnological processes and replacing multiple-stage chemical syntheses. In this work we evaluated the ability of bacteria belonging to the Rhodococcus genus to biotransform substrates, such as cortisone and hydrocortisone, to obtain prednisone and prednisolone, respectively. These products are of great interest from a pharmaceutical point of view as they have higher anti-inflammatory activity than the starting substrates. After an initial lab-scale screening of 13 Rhodococcus strains, to select the highest producers of prednisone and prednisolone, we reported the 200 ml-batch scale-up to test the process efficiency and productivity of the most promising Rhodococcus strains. R. ruber, R. globerulus and R. coprophilus gave the Δ1-dehydrogenation products of cortisone and hydrocortisone (prednisone and prednisolone) in variable amounts. In these biotransformations, the formation of products with the reduced carbonyl group in position C20 of the lateral chain of the steroid nucleus was also observed (i.e., 20β-hydroxy-prednisone and 20β-hydroxy-prednisolone). The yields, the absence of collateral products, and in some cases the absence of starting products allow us to say that cortisone and hydrocortisone are partly degraded.
Tackling Performance Challenges in Organic Photovoltaics: An Overview about Compatibilizers
Authors: Bonasera Aurelio , Giuliano Giuliana , Arrabito Giuseppe , Pignataro Bruno
Published: May 2020

Organic Photovoltaics (OPVs) based on Bulk Heterojunction (BHJ) blends are a mature technology. Having started their intensive development two decades ago, their low cost, processability and flexibility rapidly funneled the interest of the scientific community, searching for new solutions to expand solar photovoltaics market and promote sustainable development. However, their robust implementation is hampered by some issues, concerning the choice of the donor/acceptor materials, the device thermal/photo-stability, and, last but not least, their morphology. Indeed, the morphological profile of BHJs has a strong impact over charge generation, collection, and recombination processes; control over nano/microstructural morphology would be desirable, aiming at finely tuning the device performance and overcoming those previously mentioned critical issues. The employ of compatibilizers has emerged as a promising, economically sustainable, and widely applicable approach for the donor/acceptor interface (D/A-I) optimization. Thus, improvements in the global performance of the devices can be achieved without making use of more complex architectures. Even though several materials have been deeply documented and reported as effective compatibilizing agents, scientific reports are quite fragmentary. Here we would like to offer a panoramic overview of the literature on compatibilizers, focusing on the progression documented in the last decade.
Banhahubak-Tang Tablet, a Standardized Medicine Attenuates Allergic Asthma via Inhibition of Janus Kinase 1 (JAK1)/ Signal Transducer and Activator of Transcription 6 (STAT6) Signal Pathway
Authors: Nam Yeon Kyung , Jin Seong Chul , Kim Mi Hye , Choi La Yoon , Lee Yong-Bok , Yang Woong Mo
Published: May 2020

Exposure to particulate matter (PM) has been known to be one of the risk factors to cause allergic asthma, leading to development of respiratory disease. Banhahubak-tang tablet (BHT), a standardized Korean Medicine, is prescribed for neurasthenia, laryngopharyngitis and asthma. In this study, we investigated therapeutic effects of BHT on airway inflammation in ovalbumin (OVA) and PM smaller than 10 μm (PM10)-induced allergic asthma mice. To establish allergic asthma with airway hyper-responsiveness by PM10, BALB/c mice were sensitized and challenged with OVA and PM10, and orally administered BHT. Histological staining was performed to assess airway remodeling. Serum and bronchoalveolar lavage fluid (BALF) was collected for measuring immunoglobulin levels and counting inflammatory cells, respectively. Expression levels of Janus kinase 1 (JAK1)/signal transducer and activator of transcription 6 (STAT6), pro-inflammatory cytokines and type 2 T-helper (Th2)-related cytokines were analyzed in vivo and in vitro models. Histopathological analysis demonstrated that BHT suppressed inflammatory cell infiltration, mucus hypersecretion and collagen deposition in the airway. BHT administration effectively decreased number of inflammatory cells in BALF. BHT reduced total serum Immunoglobulin E (IgE) and Immunoglobulin G (IgG) levels. In addition, BHT significantly inhibited the phosphorylation of JAK1 and STAT6 expressions. Release of pro-inflammatory cytokines and Th2-related cytokines were down-regulated by BHT. In conclusion, BHT mitigated airway inflammation by down-regulating pro-inflammatory and Th2-related cytokines via JAK1/STAT6 signaling. BHT might be a promising herbal medicine for preventing airway inflammation. Moreover, an intervention study among humans is needed to further evaluate the possible beneficial effects of BHT in allergic asthma.