bluuebunny/crossref_metadata_2025 huggingface dataset:
Trends in antimicrobial resistance in Gaza Strip, 2020–2022
Authors: Mansour Hashem M. , Kurraz Rana A. , Rabii Ahmed Al , Masood Khalil I.
Published: June 2023

Background:
In this study, we analyzed the data on antimicrobial resistance in the bloodstream. This study aims to evaluate the bacterial resistance in the Gaza Strip and compare with that in other countries.
Methods:
This study was conducted retrospectively in the Indonesian and Shifa hospitals in the Gaza Strip of Palestine. The isolates were collected from 2020 to 2022 and compared with those from other countries. Chi square test to compare between means. P- value less than 0.05 was considered statistically significant
Results:
The incidences of bloodstream infections as well as the resistance against most antibiotics increased. The exceptions were a decreased incidence of P. aeruginosa infection and a decrease in resistance against ceftazidime. Overall, the incidence and resistance of antimicrobials were higher than other countries.
Conclusion:
These results showed increased trends to bacterial resistance except for ceftazidime. A specialist in clinical microbiology should take an active role in prescribing antibiotics in hospitals based on laboratory and epidemiological data besides clinical experience. Also, antibiotic stewardship should be constructed and activated in our country to, as this will decrease the emergence of resistant strains and decrease the burden
Mechanism of no-wear super-slip design of tribo-pair in load lifting and friction reduction
Authors: Hu Qiong , Wang Jinhua , Xiao Yang , Wang Yan , Wang Xiaolei , Zhou Jiawang
Published: June 2023

The concept of “super-slip design” is used to investigate the influence of multiple factors on the opening and frictional forces of a tribo-pair with microscale grooves. The results demonstrate that significantly improving the load-carrying capacity and reducing the viscous friction can be simultaneously realised by super-slip modification of the bottom surface of the hydrodynamic groove as a result of the joint action of the super-slip surface, groove geometrical parameters, and operating conditions. This is expected to further enhance the load-carrying capacity and reduce friction by applying shear stress on the interface of the liquid film and superslippery surface of the groove bottom. The superslippery surface does not fail because of rubbing, and the logical relationship between the performance parameters and groove depth changes unusually under this design.
Leaf-height-seed strategy of paired Meconopsis species and their impact factors along the elevational gradients in the south-eastern margin of Qinghai- Tibet Plateau
Authors: Shi Ning , Wang Jinniu , Zhang Lin , Wu Yan
Published: June 2023

Plant functional trait reflects plant growth information and resource utilization strategy. Leaf-height-seed (LHS) scheme is to quantify the strategy of plants by the location of three easily measurable functional traits in three-dimensional space. We applied this scheme to paired Meconopsis species to assess the variation of life-history traits over altitudinal gradients in the south-eastern margin of Qinghai-Tibet Plateau. LHS traits of 3 ~ 6 M. punicea and M. integrifolia populations had been measured. Furthermore, the impact of environmental factors on LHS traits had been addressed by regression models. We found both species displayed a significant decrease with increasing elevation for plant height and only the SLA of M. punicea varied significantly among elevations, while the elevation had no significant effect on seed mass. Moreover, most LHS traits have no significant relationships within species. Along the elevational gradient, the LHS strategies adopted by these two species varied to some extent. At high elevation, M. punicea tended to adopt conservative nutrient utilization strategies and enhance surviability, while M. integrifolia tended to adopt strategies that ensured rapid nutrient utilization and enhanced surviability. The most important environmental factor for their trait variation is the average growing season mean temperature. Variations in LHS traits of a single species suggested that plant strategy determined by the position within this three-factor triangle is not constant along the elevational gradient. Additionally, our study didn’t support some previously established cross-species correlations for interspecific patterns of LHS traits not widespread within species.
Friction and degradation of graphite: a nanotribological approach
Authors: Kim J. M. , Caron Arnaud
Published: June 2023

We investigated the friction and wear of graphite by atomic force microscopy in sliding contact with SiOx, Pt, and diamond tips with contact forces up to several micronewtons. Graphite’s tribology strongly depends on the chemistry of the counter body. With a SiOx tip, friction is governed by puckering. Wear initiates at surface steps by mechanical destabilization of folds. With a Pt tip, the adhesive effects lead to the exfoliation of graphite. At higher loads, friction crosses over from exfoliation to puckering. For SiOx and Pt, the wear rate is low in ambient conditions. In the case of diamond tips, we measured a friction coefficient and a wear rate of an order of magnitude larger than with SiOx or Pt tips.
Light and oxygen caused degradation of carbon nanotubes supported platinum catalyst in storage
Authors: Li Xiang , Li Lingling , Wu Yun , Cao Gengyu
Published: June 2023

Platinum (Pt) based catalysts are widely used in fuel cells due to its high catalytic activity. However, the high price and insatiability of Pt have hampered its commercial application. Enhancing the stability of Pt-based catalysts is very important. In this study, the degradation of Pt-based catalysts under storage conditions has been investigated. Both the oxygen and light will cause the degradation of Pt in storage conditions. However, the oxidation caused by light and oxygen alone is very slight, and the oxidation of Pt is obvious when oxygen and light work together.These findings provide a new sight in investigating the degradation mechanism of Pt-based catalysts.
Biomarkers Classification for Various Brain Disease using Artificial Intelligence Approach-A Study
Authors: Reeja S R , Mounika Sunkara , Mohanty Sachi Nandan
Published: June 2023

Diagnostic and prognostic markers for disease identification Furthermore impact of treatment on the illness continues to be a significant restriction in science. As a matter of fact, initial determination and guess of the sickness are hindered by a lack of suitable markers, and as a result, many lives are lost due to a variety of diseases because diagnosis occurs too late for a severe form of the illness because it is challenging to comprehend a recurrence. An illness’s medical condition can be positively identified using biomarkers. Diagnostic biomarkers may be crucial in this situation to make a precise diagnosis, identify individuals with a disease, and classify people with the same type of condition to tailor pharmacological therapies and boost therapeutic response. As a result, these biomarkers may be helpful for more than only diagnosing diseases; they may also be able to anticipate how a patient will respond to treatment. Research in the biology of disease is therefore heavily focused on finding appropriate and useful biomarkers for disease. Finding disease-specific biomarkers has recently been aided by deep learning. Brain functional connectivity (FC) changes may serve as biomarkers for forecasting several types of brain diseases. When the alterations are modest and there aren't any major structural changes overall, fMRI may be able to find abnormalities in the brain that other imaging methods can't. FMRI analytics are frequently used in various brain investigations, even clinical trials, in conjunction with deep learning models.
Gaussian-state Ansatz for the non-equilibrium dynamics of quantum spin lattices
Authors: Menu Raphaël , Roscilde Tommaso
Published: June 2023

The study of non-equilibrium dynamics is one of the most important challenges of modern quantum many-body physics, in relationship with fundamental questions in quantum statistical mechanics, as well as with the fields of quantum simulation and computing. In this work we propose a Gaussian Ansatz for the study of the nonequilibrium dynamics of quantum spin systems. Within our approach, the quantum spins are mapped onto Holstein-Primakoff bosons, such that a coherent spin state - chosen as the initial state of the dynamics - represents the bosonic vacuum. The state of the system is then postulated to remain a bosonic Gaussian state at all times, an assumption which is exact when the bosonic Hamiltonian is quadratic; and which is justified in the case of a nonlinear Hamiltonian if the boson density remains moderate. We test the accuracy of such an Ansatz in the paradigmatic case of the S=1/2S=1/2 transverse-field Ising model, in one and two dimensions, initialized in a state aligned with the applied field. We show that the Gaussian Ansatz, when applied to the bosonic Hamiltonian with nonlinearities truncated to quartic order, is able to reproduce faithfully the evolution of the state, including its relaxation to the equilibrium regime, for fields larger than the critical field for the paramagnetic-ferromagnetic transition in the ground state. In particular the spatio-temporal pattern of correlations reconstructed via the Gaussian Ansatz reveals the dispersion relation of quasiparticle excitations, exhibiting the softening of the excitation gap upon approaching the critical field. Our results suggest that the Gaussian Ansatz correctly captures the essential effects of nonlinearities in quantum spin dynamics; and that it can be applied to the study of fundamental phenomena such as quantum thermalization and its breakdown.
Environmental Crisis in Urban Areas in J. G. Ballard’s Short Stories
Authors: AĞIR Barış
Published: June 2023

This study mainly applies Lawrence Buell’s environmental criticism to study the urban environment in J. G. Ballard’s short stories from two aspects: the environmental problems and humankind’s failed resistances to them. Through studying these aspects, the paper discloses Ballard’s reproof of the industrial society’s disrespect towards nature and his ecological concerns over the development of both the environment and the human being. The paper will study the status of the urban environment from two angles: the absence of green landscape and the prevalence of pollution. The paper will interpret how the characters attempt to resist the predicaments but end up in failures. Though their attempts do not succeed, seeing from Buell’s theory, this kind of pessimistic extremity in Ballard’s imagination could also reflect his determination of arousing readers’ awe in facing nature and their consciousness of environmental protection. By stressing the environmental predicaments, humankind’s crises under the predicaments, and the futile resistances, Ballard’s urban short stories express a profound ecological concern with the urban environment and humanity’s existential status.
The Mainstreaming of Environmental Criticism: Theory and Nature
Authors: METE Barış , ERDEM METE Defne
Published: June 2023

Contemporary theory has been framed by structuralist, poststructuralist and postmodernist discussions about social, cultural and linguistic formation of meaning. Structuralists argue that meaning is an external feature. It depends on the linguistic framework, for it is defined in and through language. For poststructuralists, meaning can be subjectively defined; thus there is no meaning to be considered. Poststructuralism offers the idea of the plurality of meaning. Like all traditional notions, meaning is a metanarrative whose validity structuralist, poststructuralist and postmodernist critics find controversial. Contemporary theory has been a liberating experience. This might be exemplified with the enquiry into the legitimacy of the patriarchy which rendered women determination to question their inequalities. Theory has enabled discussions about the proletariat having a future to control production. However, theory has illustrated nature within the same exemplification. Nature is a socially, culturally and linguistically constructed notion defined as a man-made perception. The present environmental emergency loses its meaning as nature is a meaningless term. Environmental criticism dismiss the latest designation of nature as a metanarrative. It insists that nature is real, alive and in danger. This article aims to point out that mainstreaming of environmental criticism helps understand the relationship between theory and nature.
Geç Dönem Osmanlı Yapılarına Trabzon’dan Bir Örnek: Tonya/Kozluca Mimari Manzumesi
Authors: ÖNAL Raziye Çiğdem
Published: June 2023

Osmanlı Devleti, mimarlık tarihi boyunca halkın inanç, eğitim, ekonomik ve sosyal ihtiyaçlarına hizmet eden yapıları yerleşim yerinin merkezini belirleyecek şekilde bir arada programlamayı bir gelenek haline getirmiştir. İnşa sürecini aynı zamanda ilerlettikleri büyük programlı külliyeler ile farklı zamanlarda ihtiyaca göre eklenen daha küçük ölçekli binalarla genişletilen manzumeler, payitaht kentlerdeki kadar büyük olmasa da Anadolu’nun her yerinde mimariye kazandırılmıştır. Tarihi İpek Yolu üzerinde bulunan ve limanlarının varlığı ile uluslararası iletişime açık olan Trabzon, devletin önemli ihtiyaçlarını gideren bir kent olduğu için mimari birikimin de yoğun olduğu kentler arasında yerini almıştır. 1461’de fethedilmesinden sonra özellikle kentin yönetim merkezinde Gülbahar Hatun (1514), İskender Paşa (1529) gibi cami, medrese, imaret, kütüphane, çeşme gibi birkaç yapının bir araya getirildiği yapı toplulukları inşa edilmiştir. 20. yüzyıla kadar süreklilik arz ederek devam eden bu yapılaşma, Trabzon’da kırsal kesimlerde de yaygınlaşmış, özellikle 19. yüzyılda cami, medrese, çeşme, imam/müderris evi gibi yapılar bir araya getirilerek birkaç köyün hizmetine sunulan kompleksler inşa edilmiştir. Bunlardan birisi de 19. yüzyılın ikinci yarısında Tonya ilçesi Kozluca Mahallesi’nde inşa edilen cami ve imam evi ile daha sonra eklenen medrese ile hizmet boyutu genişletilen Kozluca Manzumesi’dir. Bu eserler, cami ve medrese birlikteliği ile ibadet ve eğitim merkezlerinin bir arada bulunmasına yerel bir örnek teşkil ettiği için bu çalışmaya konu olarak seçilmiştir. Mimari ve süsleme özellikleri irdelenerek hem geç dönem Osmanlı mimarisinin özellikleri hem de Trabzon’un yerel mimari karakterinin eserlere ne şekilde yansıdığını tespit etmek amaçlanmıştır.
İhtiras ve Servetin Gölgesinde Bir Sultan: Fatma Sultan
Authors: CİVELEK Gökhan , ÇAKIR İbrahim Etem
Published: June 2023

Bu çalışmada Fatma Sultan’ın hayatı, evlilikleri, serveti ve servetinin kaynağı, lüks yaşantısı, ev eşyaları, maddi kültürün önemli unsuru olan giyim-kuşam ürünleri, takı ve aksesuarları hakkında bilgilere yer verilmiştir. Fatma Sultan, babası Sultan I. Ahmed, kardeşleri Sultan II. Osman, Sultan IV. Murad ve Sultan İbrahim’in saltanatını görmüş, annesi Kösem Sultan’ın muktedir olduğu döneme şahit olmuş ve aynı zamanda yeğeni Sultan IV. Mehmed’in hükümdarlığına da yetişmiştir. Bu sayede yaşamı boyunca hanedan içinde, saray çevresinde ve devlet idaresinde itibarlı ve saygın bir konuma sahip olmuştur. Fatma Sultan Topkapı Sarayı’ndan ayrıldıktan sonra genellikle Eyüp semtindeki konağı ve çiftliklerinde şaşaalı bir hayat sürmüştür. Konağında kullandığı ev eşyaları lüks hayatının somut bir göstergesidir. Fatma Sultan’ın giyim-kuşam malzemeleri ve takıları ise bir servet değerindedir. Dış giyim unsurları olarak pahalı ve gösterişli kürkler, kaftanlar ve kuşaklar öne çıkmaktadır. Elmas, yakut, zümrüt gibi kıymetli taşlarla süslenmiş takı ve ziynet eşyaları arasında saat, bilezik, küpe ve incileri yer almaktadır. Kıyafet ve takılarında olduğu gibi ev eşyaları da ihtiyaçtan ziyade gösteriş ve zenginliğini yansıtan unsurlar arasındadır. Arşiv kaynakları, dönemin kronik ve seyahatname eserlerinden yararlanılarak hazırlanan bu çalışma Fatma Sultan özelinde Osmanlı hanedanına mensup sultanların evlilikleri, lüks tutkuları, iktidar hırsları ve giyim-kuşamları hakkında teferruatlı bilgiler içermesi bakımından bu alandaki literatüre katkı sağlayacaktır.
Does neglecting the instruments of financial failure play a role in the bankruptcy of companies?
Authors: Douha Selma , Bouali Soufyane , Nadjib Khadri
Published: June 2023

Corporate financial analysis tools are an important factor in corporate efficiency. Low-quality accessories for corporate financial analysis tools really brutally violate the interests of shareholders and can lead to the collapse of the business. The paper examines the development of models for predicting financial crises and compares the capabilities of existing models that can help alert management to current activity regarding an economic decision to buy shares or make loans. In the example of the NCA RUIBA company, Kida and Sherrod models were considered for predicting the financial failure of a firm. Based on the results of the calculations, it can be noted that NCA RUIBA had a good financial position when calculating the indicators according to Kida’s model, and according to the calculated data of the Sherrod model, the organization relies on external financing through high-risk loans, which is associated with the growth of non-current liabilities, especially long-term and medium-term ones. The results suggest that although corporate financial analysis tools alone are not sufficient to accurately predict financial distress, they can increase the predictive power of financial indicators and macroeconomic factors.
Languishing and flourishing experiences in schizophrenic patients during hospitalization
Authors: Fathinah Amirah , Istiningtyas Listya , Situmorang Dominikus David Biondi
Published: June 2023

Hospitalization affects the emotional, psychological, and social well-being of schizophrenic patients. The process can produce experiences of both flourishing and languishing. This study aims to identify and describe such experiences of schizophrenic patients during hospitalization. A phenomenological qualitative method was employed with six schizophrenic patients hospitalized at Ernaldi Bahar Hospital in Palembang, Indonesia. Research data were collected using semi-structured interviews and documentation methods. These were analyzed using thematic analysis. The findings demonstrate the developing experiences of schizophrenic patients during hospitalization; there are three themes: 1) experiencing increased contact with and awareness of reality, 2) finding meaning and purpose in life, and 3) finding positive relationships among patients. Languishing experiences were also classified into three themes: 1) feeling bored and confined, 2) experiencing unpleasant events on arrival, and 3) experiencing social isolation. In particular, clinical struggle, functional recovery, and cultural struggle are predictors of the flourishing and languishing experiences of hospitalized schizophrenic patients. The findings contribute to developing the concept of languishing and flourishing among such patients through evidence-based empirical data regarding the efforts to foster and maintain their subjective well-being during hospitalization.
Outbreaks of Neoechinorhynchus buttnerae (Acanthocephala) infection in raised semi-intensively Colossoma macropomumin Theobroma, Rondônia state, Western Amazon
Authors: Lucena Carina Fernanda Pereira de Jesus , Dantas Filho Jerônimo Vieira , Ferreira Aristoteles Marcos Silva , Rocha Ana Sabrina Coutinho Marques , Schons Sandro de Vargas , Gasparotto Paulo Henrique Gilio
Published: June 2023

The aim of this study was to describe two outbreaks of Neoechinorhynchus buttnerae parasitizing Colossoma macropomum raised semi-intensively in the Theobroma municipality, Rondônia state, Brazil. It was reported by owner that the animals had a history of poor weight gain and decreased food intake. C. macropomum that weighed around 1.5 kg were clinically evaluated where the body surface, fins, buccal and brachial cavity were carefully analyzed and no changes were found. N. buttnerae was the only intestinal parasite found in the specimens studied, and its distribution pattern showes a preference for the posterior portion of the intestine of C. macropomum. All 50 fish examined were parasitized by at least one N. buttnerae. This parasite was found in the digestive system of the examined fish. 100% of prevalence, 430 of intensity, 8.6 of average intensity and average abundance were found. Although there was no record of mortalities due to acanthocephalosis, damage that compromised the feed conversion of the fish was recorded. C. macropomum were infected by ingesting a crustacean containing cystacanth, the infective larval form of the parasite. Damage, such as presence of nodules, hypertrophy of goblet cells, thickening of the muscle layer, metaplasia in muscle tissue, severe edema from leukocyte infiltration in blood vessels and necrotic foci, were found in the intestine due to high infection rates of N. buttnerae. That said, inspection activities are essential for the preservation of consumer and animal health.
Electrochemical Label-free Methods for Ultrasensitive Multiplex
Protein Profiling of Infectious Diseases
Authors: Madhurantakam Sasya , Churcher Nathan Kodjo Mintah , Kumar Ruchita Mahesh , Prasad Shalini
Published: June 2023

Electrochemical detection methods are the more appropriate detection methods
when it comes to the sensitive and specific determination of biomarkers. Biomarkers
are the biological targets for disease diagnosis and monitoring. This review focuses on recent
advances in label-free detection of biomarkers for infectious disease diagnosis. The
current state of the art for rapid detection of infectious diseases and their clinical applications
and challenges were discussed. Label-free electroanalytical methods are probably
the most promising means to achieve this. We are currently in the early stages of the
emerging technology of using label-free electrochemistry of proteins to develop biosensors.
To date, antibody-based biosensors have been intensively developed, although
many improvements in reproducibility and sensitivity are still needed. Moreover, there is
no doubt that a growing number of aptamers and hopefully label-free biosensors based
on nanomaterials will soon be used for disease diagnosis and therapy monitoring. And also
here in this review article, we have discussed recent developments in the diagnosis of
bacterial and viral infections, as well as the current status of the use of label-free electrochemical
methods for monitoring inflammatory diseases.
Dietary Components and Nutritional Strategies for Dementia Prevention in the Elderly
Authors: Cao Xi-Peng , Xu Wei , Wang Zuo-Teng , Tan Lan , Yu Jin-Tai
Published: June 2023

Background:

For decades, evidence from observational studies and randomized controlled trials has converged to suggest associations of dietary components, foods, and dietary patterns with dementia. With population aging and a projected exponential expansion of people living with dementia, formulating nutritional strategies for dementia prevention has become a research hotspot.

Objective:

This review aimed to summarize available data on the roles of specific dietary components, food groups, and dietary patterns in dementia prevention among the elderly.

Methods:

Database search was carried out using PubMed, the Cochrane Library, EMBASE, and Medline.

Results:

Polyphenols, folate, vitamin D, omega-3 fatty acids, and β-carotene might decrease the risk of dementia. Consumption of green leafy vegetables, green tea, fish, and fruits is recommended. However, saturated fat, a diet rich in both dietary copper and saturated fat, aluminum from drinking water, and heavy drinking might increase dementia risk. Healthy dietary patterns, especially the Mediterranean diet, were proven to bring more cognitive benefits than single dietary components.

Conclusion:

We discussed and summarized the evidence on the roles of dietary components and patterns in dementia prevention among the elderly and found that some factors were closely associated with dementia risk in elderly. This may pave the way for the identification of dietary components and patterns as new therapeutic targets for dementia prevention in the elderly population.
Investigating the Effects and Side Effects of Two Antipsychotic Drugs in
the Treatment of Children and Adolescents with Tourette Syndrome: A
Semi-experimental Research
Authors: Soltanifar Atefeh , Lashkarnevis Raheleh , Ziaee Maliheh , Moharari Fatemeh , Samadi Roya , Soltanifar Azadeh , Kamrani Maedeh
Published: June 2023

Introduction:

Due to the high prevalence of Tourette's disorder among children and adolescents
and its negative consequences, an appropriate and effective medical treatment with minimal
complications is necessary. Therefore, this study was conducted to compare the effects of Aripiprazole
and Risperidone on Tourette's disorders in children and adolescents.

Method:

The statistical population of this semi-experimental study was children and adolescents aged
seven to eighteen years old. They were diagnosed with Tourette's disorder based on the DSM-V criteria
by the clinical interview of a child and adolescent psychiatrist in the child Psychiatry clinic of Ibne-
Sina's Psychiatric Hospital (Mashhad-Iran) in 2018. A total of forty participants were selected by the
convenience sampling method, and they were randomly divided into two groups treated with medicines,
Risperidone or Aripiprazole, for two months. Then, the demographic information questionnaire
was completed. The Y-GTSS Scale was completed. The clinical Effect Rating Scale (CGI-Tics Scale)
was completed. Calculation of body mass index and medical side effects complications were completed.
The evaluation was carried out at the beginning and on the second, fourth, and eighth weeks, and
the results were compared. The data were analyzed using SPSS software. 14, descriptive statistics,
Chi-square, and variance analysis.

Results:

The two groups were homogeneous in terms of demographic variables and body mass index.
Despite the positive effect of both medicines, no significant difference was observed among the general
scores of such disorders, the overall score of severity, Tourette's recovery, and BMI of these two
groups at the intervals and the end of treatments. (p <0.05). Due to the low number of complications
reported, statistical comparisons of the medical side effects were not made.

Conclusion:

According to the results, the two medicines, Aripiprazole and Risperidone, effectively improved
the symptoms of Tourette's disorder and its overall severity. However, there were no significant
statistical differences between them. Furthermore, in terms of the medical side effects, the statistical
comparison between the two medicines was impossible due to the small number of complications.
“Thiophene”: A Sulphur Containing Heterocycle as a Privileged Scaffold
Authors: Narayan Yuthika , Kumar Ajay , Parveen Aamna
Published: June 2023

:

In the rapidly expanding chemical realm of heterocyclic compounds with interesting therapeutic
properties, the thiophene nucleus has established itself as a prospective entity. The biological activity
of comparable substances produced via different pathways is of varying magnitudes. Medicinal chemists
use their understanding of multiple synthetic pathways and the various physicochemical properties of
such compounds to create a combinatorial library and conduct thorough searches for lead molecules. Due
to their vast spectrum of biological actions, heterocyclic compounds play a crucial role in Medicinal
chemistry and are extensively researched in the field of drug design and development. Thiophene, a sulfur-
containing heterocyclic scaffold, has emerged as a rather well-explored scaffold for the synthesis of a
library of molecules with biological functions, including antibacterial, antipsychotic, anticancer, analgesic,
anti-inflammatory, anti-arrhythmic, and so on. Depending on the kind and position of substitution,
thiophene analogues have been shown to bind to a wide spectrum of cancer-specific protein targets. As a
result, thiophene analogues have been found to exert their biological effects by inhibiting various cancerrelated
signalling pathways. The study of thiophene in Medicinal chemistry resulted in molecules that
combine the thiophene moiety with traditional drug components in a single molecule. This review covers
the biological and medical activity of compounds containing a thiophene nucleus, as well as information
on thiophene behaviour, synthesis, and agents, with a focus on synthetic techniques, biological profiles,
and structure-activity relationship (SAR) research.
Determination of Two Potential Genotoxic Impurities in Crisaborole API
by UPLC-MS/MS
Authors: Zhang Mengmeng , Zou Qiaogen
Published: June 2023

Background:

Atopic dermatitis (AD) is an allergic skin disease that can be inherited. Crisaborole is a specific drug developed to deal with this disease. The compounds of 4-(4-Bromo-3-formyl-phenoxy)-benzonitrile and 4-(4-(4-bromo-3-formylphenoxy)-3- formylphenoxy)benzonitrile are the representative impurities in the synthesis of Crisaborole active pharmaceutical in gradient (API). Owing to the genotoxic impurities that could lead to cancer and gene mutations, it is necessary to develop a simple, efficient, sensitive, and accurate method to detect these impurities. In this study, the 4-(4-Bromo-3-formyl-phenoxy)-benzonitrile and 4-(4-(4-bromo-3-formylphenoxy)-3-formylphenoxy)benzo- nitrile present in Crisaborole API were detected using UPLC-MS/MS.

Methods:

The separation was made on a ZORBAX Eclipse XDB-Pheny column (4.6 mm ×75mm, 3.5 μm) with the mobile phase of acetonitrile solution containing 0.1% trifluoroacetic acid (A) and water containing 0.1% formic acid (B) in gradient elution mode. Quantification was performed using positive ion electrospray ionization (ESI), and the contents of two compounds were determined using the multiple reaction monitoring (MRM) modes.

Results:

The quantitative analytical method was fully validated with respect to linearity (r>0.9998), sensitivity, precision, accuracy (the average recovery of two impurities was 84.1% to 90.7%), and robustness.

Conclusion:

Three batches of samples were detected by UPLC-MS/MS, indicating that the proposed approach was applicable for the quality evaluation of Crisaborole.
Corrigendum to: Editorial: Anticancer Platinum Complexes - State of the Art and
Future Prospects
Authors: Galanski Mathea Sophia
Published: June 2023

An Editorial was published in the journal "Anti-Cancer Agents in Medicinal Chemistry", Volume 7, No. 01, 2007, pp: 1-2 [1]. The guest editor
is requesting an alteration in the name.

Details of a correction are provided here.

The original name published was Markus Galanski. The request is to change the name to Mathea Sophia Galanski.

The original editorial can be found online at: https://www.eurekaselect.com/article/3355
The Peripheral Profile of the Chitinase 3-like-1 in Benign Multiple
Sclerosis – A Single Centre’s Experience
Authors: Barcutean Laura , Hutanu Adina , Andone Sebastian , Maier Smaranda , Balasa Rodica
Published: June 2023

Background:

A limited subgroup of multiple sclerosis (MS) patients present with a longterm
disease evolution characterized by a limited disease progression, known as benign MS (BMS).
Chitinase 3-like-1 (CHI3L1) levels are sensitive to inflammatory processes and may play a role in the
pathogenesis of MS. In this observational, cross-sectional study, we aimed to evaluate the implications
of serum CHI3L1 and inflammatory cytokines in BMS patients treated with interferon β-1b for over a
decade.

Methods:

We collected serum samples from 17 BMS patients and 17 healthy controls (HC) to measure
serum CHI3L1 levels and a Th17 panel of inflammatory cytokines. Serum levels of CHI3L1 were
analysed using the sandwich ELISA method and the Th17 panel was assessed using the multiplex
XMap technology on a Flexmap 3D Analyzer.

Results:

Serum CHI3L1 levels did not differ significantly from HC. We identified a positive correlation
between CHI3L1 levels and relapses during treatment.

Conclusions:

Our findings suggest that there are no differences in serum CHI3L1 levels between BMS
patients and HC. However, serum CHI3L1 levels are sensitive to clinical inflammatory activity and
may be associated with relapses in BMS patients.
Photocatalytic Multi-Component Reactions: An Emerging Avenue
Authors: Ariya Sreekumar , Neetha Mohan , Anilkumar Gopinathan
Published: June 2023

In recent years, photocatalytic multi-component reactions have emerged as a cutting-edge
innovation in the field of organic synthesis. These reactions allow the simultaneous transformation
of multiple reactants, which not only saves time and resources but also provides access to a
diverse range of complex molecules. The use of photocatalysts in these reactions provides several
advantages, including mild reaction conditions, high selectivity, and high functional group tolerance.
Moreover, the integration of renewable energy sources such as visible light as a driving force
for these reactions further adds to their sustainability. This innovation has opened up new avenues
for the synthesis of complex molecules and holds great promise for the development of sustainable
and efficient chemical processes. This review gives a broad understanding of photocatalyzed multi-
component reaction protocols developed with wide applications in synthetic organic chemistry.
These green, efficient, and straightforward reactions utilize recyclable photocatalyst, solvent-free
or catalyst-free conditions for the synthesis of compounds with biological significance in a costeffective
fashion. They are easily purified due to the minimum or no by-product formation. The
review is divided into sections based on the type of photocatalysts involved and covers literature
up to 2022.
A Critical Appraisal of Functional Hydrogels for Chronic Wound
Healing: Recent Advances and Ongoing Research
Authors: Markandeywar Tanmay S. , Singh Dilpreet , Narang Raj Kumar
Published: June 2023

In diabetic wounds, reactive oxygen species (ROS) are developed in large quantities in a
consistently hyperglycemic and excessive biogenic environment. Inflammatory factors are increased as
a result of impaired hematopoiesis. Because, subsequent infections obstruct the healing process and as
a result, most chronic wounds are not healed properly. The majority of chronic diabetic wounds are
worsened during the inflammatory stage. Because of excessive ROS, it is still challenging for a timely
closure of diabetic chronic wounds. Wound dressings with anti-inflammatory and ROS scavenging
properties are preferable for the treatment of diabetic wounds. Hence, a strategic treatment is required
which facilitates both targeting and myogenic potential. In recent decades, the production of
macroporous hydrogels via three-dimensional (3D) printing has gained popularity as a cutting-edge
technique for chronic wounds. Multiple hydrogel subtypes have been formulated for different states of
healing of chronic wounds. The hydrogel used in 3D printing indicated better wound healing by enhancing
the expression of adipose-derived stem cells (ASCs) activities in scaffolds due to the presence
of an ordered macroporous structure. Regenerative medicine has undergone a paradigm shift as a result
of the introduction of inventive medicines based on the use of living organisms. New treatments for
skin wounds have been the subject of several studies, with bioactive peptides, nanoparticles, and hydrogels
attracting a lot of attention due to their potential as therapeutics. For chronic wound healing,
hydrogels create an angiogenesis microenvironment and avoid wound infections. Hence, the present
review provides light on different superficial hydrogels along with their properties for chronic wound
healing.
Financial information system user satisfaction and its impact on organizational performance
Authors: Widodo Dwi Mardi , Sutrisno T , Baridwan Zaki
Published: June 2023

The successful implementation of the use of a comprehensive financial information system in Ministries/Institutions in the form of developing an Institutional Level Financial Accounting System (SAKTI) is important in supporting the management of the state budget so that it can run effectively and efficiently. Human, technological, and organizational variables all play an important role in the development of information technology-based information systems. This study aims to measure and evaluate the factors that influence the success of the Financial Accounting System at the Agency Level with the Modification of the Delone and Mclean Models. This research is a quantitative analysis utilizing survey-based primary data. Respondents to this study were SAKTI users at the Secretariat General of the Ministry of PUPR. The sample used in this study was 100 respondents. Data collection techniques through questionnaires. The sampling technique uses a saturated sampling method (census). The analysis technique in this study used the SEM Structural Equation Model with the SmartPLS program. The results of hypothesis testing show system quality, information quality, service quality, and user training positively impact user satisfaction. In addition, user satisfaction also has a positive effect on organizational performance.
Desenho de tarefas baseado em erros com números complexos
Authors: Damas Beites Patrícia , Andrade Ferreira Peel Misleine , Costa Cecília
Published: June 2023

Consideram-se produções de estudantes, do ensino universitário, para uma tarefa de demonstração num momento de avaliação individual. Atendendo aos conceitos matemáticos associados à avaliação, pretende-se classificar os erros nas produções e, com base nestes, construir tarefas para a sala de aula. Neste sentido, a investigação qualitativa recorre a análise de conteúdo com critérios novos de categorização de erros. Identificam-se erros relacionados com a compreensão de consequências da definição de módulo de número complexo e de estratégias de demonstração em matemática. As propostas, para os estudantes explicarem e darem sentido a erros com números complexos, são: questões conceptuais; exemplos erróneos; tarefas de completamento; tarefas de modificação do enunciado.
Planning a site for new village or small town to safeguard the health of the population
Authors: Bekele Damtew
Published: June 2023

There is no doubt that health will help reduce the transmission of infectious agents. For the health of individuals, the prior elements to be fulfilled include the availability of pure water, keeping sanitation and hygiene are necessary for reducing infection of all sorts. To make these, change of habits by involving community participation in both urban and rural areas are inevitable to combat communicable diseases. It can be achieved also if initiations should be taken and participation held in both governmental and non-governmental organizations in issues related to the health of the nation. Furthermore, the creation of awareness of the prevailing problems is a prerequisite for any plan of action towards improving the situation.
Спектроскопия двухвалентного самария в монокристаллах иодида цезия
Authors: Софич Д.О. , Шендрик Р.Ю.
Published: June 2023

The article describes the process and parameters of growing CsI:Sm2+ single crystals by the Czochralski method. Spectroscopic studies of the CsI:Sm2+ single crystal have been carried out; it has been established that samarium ions enter the caesium iodide single crystal in the divalent state. At room temperature, luminescence is observed corresponding to the 4f55d1-4f6 transitions of divalent samarium; on cooling, only radiative 4f6-4f6 transitions are observed. The temperature dependence of the luminescence has been measured, the barrier energy has been determined, and the decay times of the luminescence have been measured.
Особенности люминесценции керамики на основе кубического (ZR-=SUB=-0.82-x-=/SUB=-HF-=SUB=-x-=/SUB=-Y-=SUB=-0.17-=/SUB=-Eu-=SUB=-0.01-=/SUB=-)O-=SUB=-1.91-=/SUB=-
Authors: Шакирова А.А. , Дементьева Е.В. , Попова Т.Б. , Заморянская М.В.
Published: June 2023

The ceramics based on cubic (Zr0.82-xHfxY0.17Eu0.1)O1.91 with different contents of hafnium were studied. In the work, the elemental composition of the samples was obtained, the cathodoluminescence (CL) spectra and decay kinetics of europium luminescence were studied. The researched showed increase in the content of hafnium doesn’t affect the position and number of observed bands in the luminescence spectrum. The electric dipole and magnetic dipole radiative transitions ratio was estimated for all samples. It’s demonstrated that a decrease in the local symmetry of the europium ion associated with an increase in the hafnium content. It’s shown the 5D0-7F1 transition Eu3+ decay time doesn’t depend on the hafnium content, but varies significantly in different regions of the sample, which can be attributed to the influence of grain boundaries.
Рентгенолюминесценция нанопорошков SrF-=SUB=-2-=/SUB=-: Eu
Authors: Дробышева А.Р. , Ермакова Ю.А. , Александров А.А. , Воронов В.В. , Батыгов С.Х. , Резаева А.Д. , Мартьянов А.К. , Седов В.С. , Тяжелов И.А. , Болдырев К.Н. , Табачкова Н.Ю. , Кузнецов С.В.
Published: June 2023

Concentration series of single-phase SrF2:Eu solid solutions with a particle size of ≈50 nm were synthesized by precipitation from aqueous solutions. The bands of europium in the di- and trivalent states as well as a band of intrinsic exciton luminescence of strontium fluoride were identified in the X-ray luminescence spectra. The most intense luminescence band is the band of trivalent europium with a maximum at 585–590 nm which corresponding to the 5D0 →7F1 transition. The highest X-ray luminescence intensities upon excitation by an X-ray tube with silver and tungsten anodes are achieved for compositions containing about 15.0 mol.% and 7.5 mol.% europium, respectively.
Электронное строение и оптические свойства соединений изомеров фуллерена С-=SUB=-90-=/SUB=- с хлором
Authors: Мурзашев А.И. , Мельникова Н.В. , Жуманазаров А.П. , Кокурин М.Ю. , Паймеров С.К.
Published: June 2023

Within the framework of Hubbard’s model using an approximation of static fluctuations, the electronic structure and optical properties of compounds of C90 fullerene isomers with chlorine atoms are investigated. The energy spectrum of π electron subsystem is shown to be divided into several unbound electronic subsystems when the number of the attached chlorine atoms becomes greater than
(or about) 30. Each of subsystems behaves like a separate system in this case. The energy spectra and optical absorption spectra of ten different chlorine compounds C90@Cln have been calculated. Their optical properties are predicted.
A Review of Practical Applications of Fluid Flow and Associated Heat Transfer Modeling in Wellbores
Authors: Kabir C. Shah
Published: June 2023

Investigations on two-phase gas/liquid flow in pipes have been under study for nearly six decades. These studies have significantly assisted in managing fluid flow in the wellbore and surface networks, leading to the separation of phases and transmission of oil and gas into the market. This study summarizes some of the main lessons learned in flow through wellbores. Besides understanding some of the fundamental principles, we focused on the practical items of interest: Conventional production scenarios for oil and gas wells; Liquid loading in gas wells; Production in geothermal wells; Heat flow from fluid flow; Transient non-isothermal wellbore modeling; Well blowout in drilling operation; Estimating static geothermal and flowing-temperature gradients in gas wells; Heat mining with fluid circulation in wellbores. Given the diversity of the methods mentioned above, understanding flows in the wellbore and the reservoir becomes equally important. One critical item is the fluid temperature measurement associated with the fluid flow that enables validation of the fluid flow rate, besides revealing information about the reservoir characteristics.
The Characteristics, Uses, and Biases of Studies Related to Malignancies Using Google Trends: Systematic Review
Authors: Kamiński Mikołaj , Czarny Jakub , Skrzypczak Piotr , Sienicki Krzysztof , Roszak Magdalena
Published: June 2023

Background

The internet is a primary source of health information for patients, supplementing physician care. Google Trends (GT), a popular tool, allows the exploration of public interest in health-related phenomena. Despite the growing volume of GT studies, none have focused explicitly on oncology, creating a need for a systematic review to bridge this gap.

Objective

We aimed to systematically characterize studies related to oncology using GT to describe its utilities and biases.

Methods

We included all studies that used GT to analyze Google searches related to malignancies. We excluded studies written in languages other than English. The search was performed using the PubMed engine on August 1, 2022. We used the following search input: “Google trends” AND (“oncology” OR “cancer” or “malignancy” OR “tumor” OR “lymphoma” OR “multiple myeloma” OR “leukemia”). We analyzed sources of bias that included using search terms instead of topics, lack of confrontation of GT statistics with real-world data, and absence of sensitivity analysis. We performed descriptive statistics.

Results

A total of 85 articles were included. The first study using GT for oncology research was published in 2013, and since then, the number of publications has increased annually. The studies were categorized as follows: 22% (19/85) were related to prophylaxis, 20% (17/85) pertained to awareness events, 11% (9/85) were celebrity-related, 13% (11/85) were related to COVID-19, and 47% (40/85) fell into other categories. The most frequently analyzed cancers were breast (n=28), prostate (n=26), lung (n=18), and colorectal cancers (n=18). We discovered that of the 85 studies, 17 (20%) acknowledged using GT topics instead of search terms, 79 (93%) disclosed all search input details necessary for replicating their results, and 34 (40%) compared GT statistics with real-world data. The most prevalent methods for analyzing the GT data were correlation analysis (55/85, 65%) and peak analysis (43/85, 51%). The authors of only 11% (9/85) of the studies performed a sensitivity analysis.

Conclusions

The number of studies related to oncology using GT data has increased annually. The studies included in this systematic review demonstrate a variety of concerning topics, search strategies, and statistical methodologies. The most frequently analyzed cancers were breast, prostate, lung, colorectal, skin, and cervical cancers, potentially reflecting their prevalence in the population or public interest. Although most researchers provided reproducible search inputs, only one-fifth used GT topics instead of search terms, and many studies lacked a sensitivity analysis. Scientists using GT for medical research should ensure the quality of studies by providing a transparent search strategy to reproduce results, preferring to use topics over search terms, and performing robust statistical calculations coupled with sensitivity analysis.
Introducing JMIR Bioinformatics and Biotechnology: A Platform for Interdisciplinary Collaboration and Cutting-Edge Research
Authors: Gamsiz Uzun Ece Dilber
Published: June 2023

JMIR Bioinformatics and Biotechnology supports interdisciplinary research and welcomes contributions that push the boundaries of bioinformatics, genomics, artificial intelligence, and pathology informatics.