bluuebunny/crossref_metadata_2025 huggingface dataset:
“Kepercayaan ditengah tantangan dan impelemntasinya bagi PPGT jemaat Patila Klasis Bone-bone di era milenial” (Di dasarkan pada Daniel 6:1-11)
Authors: jaya Agung
Published: December 2019

Kepercayaan adalah sesuatu yang harus dilakukan bukan hanya diyakini sebagai suatu kebenaran. Daniel sudah menunjukkan hal tersebut dengan tetap percaya pada Allah meskipun ditengah tantangan karena imannya sehingga PPGT jemaat Patila Klasis Bone-bone Gereja Toraja harus meneladani sikap dari Daniel. Orang muda yang luar biasa yang mempunyai kedudukan yang tinggi didalam tiga kerajaan pada zamannya.
PEMETAAN TEMA DAN SUB TEMA PEMBELAJARAN TEMATIK SD MI Oleh kelompok 2, nama: Naduma Sari Siregar, Nur Jannah, Risda Handayani, Tina Melinda dan Wilda Hayati
Authors: ritonga indah pertiwi
Published: December 2019

Kurikulum 2013 merupakan kurikulum baru yang mulai diterapkan pada tahun pelajaran 2013/2014. Kurikulum ini adalah pengembangan dari kurikulum sebelumnya, yang menjadi titik tekan pada Kurikulum 2013 ini adalah adanya peningkatan dan keseimbangan soft skills dan hard skills yang meliputi aspek kompetensi sikap, keterampilan, dan pengetahuan. Kemudian, kedudukan kompetensi yang semula diturunkan dari mata pelajaran berubah menjadi pelajaran dikembangkan dari kompetensi. Dapat dipahami bahwa Kurikulum 2013 pula pada proses pembelajaran tematik seperti yang tercantum dalam Permendikbud No. 57 Tahun 2014, bahwa setiap mata pelajaran disajikan dengan tema.
PERANAN SISTEM INFORMASI MANAJEMEN DALAM MENINGKATKAN KINERJA PERUSAHAAN
Authors: Ningsih Puja , sabandi ahmad
Published: December 2019

This study aims to obtain information about the role of Management Information Systems in improving company performance. The method used in this research is literature study method by collecting literature (reading material / material) sourced from books, journals, and other sources related to the knowledge of Management Information Systems and using qualitative data. Qualitative data is data obtained during observations. The technique used is the technique of giving tasks and making observations through the development and the extent to which the approach is applied. Management Information Systems are built in order to improve company performance. While the company's performance is determined by how well business processes are designed, managed, and coordinated or managed. In other words, business processes are a source of company success, while Management Information Systems are management tools for improving business processes.
Administrasi Peserta Didik
Authors: Wulandari Ersyah Okta
Published: December 2019

Administration is a process carried out by personnel (groups) in an organization to achieve organizational goals.
Administrasi Pendidik dan Tenaga Kependidikan
Authors: Wulandari Ersyah Okta
Published: December 2019

Administration can be interpreted as an activity or business to help, serve, direct or manage all activities in achieving a goal.
PENGERTIAN DAN PROSES ADMINISTRASI PENDIDIK DAN TENAGA KEPENDIDIKAN
Authors: Ramadhani Syukri
Published: December 2019

Preparationannual, semi-annual, monthly and weekly work plans.Test preparationand exam schedules, preparation of book lists and learning tools to be used in activities forimprove student achievement, Prepare assessment norms, Record and report resultsstudent achievement activities. Preparation of schedules and planned learning activities at schoolclassrooms and outside classrooms. Data obtained by dividing the documents that must bemade with the number of lessons the teacher without coordination or discussion made in detail made byteacher so there is a possibility of dissent. Professional educators and education personnel are two professions that are interrelated in an education system, even though both have different scopes. This can be seen from the understanding of the teaching and educational staff contained in article 39 of Law no. 20 of 2003 paragraphs (1) and (2)By improving manufacturing systemsadministration curriculum.the quality of graduates in accordance with the expectations of parents, community and users of graduates. Administration is not only in financial matters but also in order in bookkeeping. not only done in a certain time, but every day systematically. The success of education in schools must be supported by regular, directed and planned school administration services.
ADMINISTRASI PENDIDIK DAN TENAGA KEPENDIDIKAN
Authors: Ramadhani Syukri
Published: December 2019

This article discusses the administration of educators and education personneIn essence educational activities always take place by involving elements of the subject or parties as important actors. The recipient subjects were students while the giver subjects were educators. Someone who wants to be an educator is required to have the criteria desired by the world of education. People who feel called to educate they love their students and have a feeling of being obliged to carry out their duties accompanied by high dedication or responsibility. The study of educators includes several things including the understanding and designation of educator terms, educator competencies, educator positions, the nature of duties and responsibilities of teachers, teacher professionalism, professional organizations and teacher code of ethic this is very much needed from a teacher in carrying out his duties with his fulfillment of this course will help in achieving the objectives of education.
konsep dasar administrasi pendidikan
Authors: handayani fitri
Published: December 2019

ABSTRAK— Educational Administration in Teaching Profession is an educational activity to develop capabilities in the field of administration. science, learning theory and skills implemented long-term goals that is that administrative staff, management and develop the knowledge that has been learned and practiced in schools"administration" comes from the Latin word consisting of ad and ministrare. The word ad has the same meaning as the todalam word in English, which means "to" or "to". And ministrare is the same as the word to serve or to conduct which means "to serve", "help", or direct ". In English to administer also means "to manage", "maintain" (to look after), and "direct". So, the word "administration" can be interpreted as an activity or effort to help, serve, direct, or regulate all activities in achieving a goal.
Administrasi tata usaha
Authors: Rahmadita Salma
Published: December 2019

this article about administrative administration
OER State Policy Playbook, 2025 Edition
Authors: Allen Nicole Starr
Published: December 2019

Open educational resources (OER) are textbooks and other course materials that are free for people everywhere to use and repurpose. States and institutions are leveraging OER to expand flexibility for faculty and reduce costs for students by millions each year. This playbook provides a set of ideas that state policymakers can consider to harness the power of OER to tackle textbook costs and make higher education more affordable and effective for all students. For the most up to date edition, visit https://sparcopen.org/oer-state-policy
MAD saccade: statistically robust saccade threshold estimation
Authors: Voloh Benjamin , Watson Marcus , König Seth , Womelsdorf Thilo
Published: December 2019

Saccade detection is a critical step in the analysis of gaze data. A common method for saccade detection is to use a simple threshold for velocity or acceleration values, which is typically estimated from the data using the mean and standard deviation. However, this method has the downside of being influenced by the very signal it is trying to detect, the outlying velocities or accelerations that occur during saccades. We propose instead to use the median absolute deviation (MAD), a robust estimator of the standard deviation that is not influenced by outliers. We modify an algorithm proposed by Nyström and colleagues, and quantify saccade detection performance in both simulated and human data. Our modified algorithm shows a significant and marked improvement in saccade detection, showing both more true positives and less false negatives. We conclude that robust estimators can be widely adopted in other common, automatic gaze classification algorithms due to their ease of implementation.
Study of Compliance of Sealed Bottled Water with Nepal Drinking Water Quality Standard: A Case of Bhaktapur Municipality, Nepal
Authors: Raj Neupane Prasidha , Bajracharya Iswor , Prajapati Meera , Sujakhu Hishila , Awal Pramod
Published: December 2019

Bottled water is generally considered safe for drinking. However, several studies have reported the substandard quality of bottled water. Physico-chemical assessment of ten different brands of bottled water distributed in Bhaktapur Municipality was carried out from January 2018 to March 2018. In total, one hundred bottled water samples consisting of ten different brands were collected randomly from various retail outlets. Eight selected physico-chemical and microbiological parameters were analysed following standard methods, and the results were compared with the Nepal Drinking Water Quality Standard (NDWQS) (2005). Out of one hundred samples, sixty-nine samples did not comply with the standard pH limit. Other physico-chemical parameters were found to comply with the standard though variations were observed in the concentrations among different brands. Microbial contamination was not found in any brands of the bottled water samples considered in this study. However, it is necessary to examine other contaminants such as heavy metals, minerals, and chemicals to know the overall quality of water. Moreover, the regulatory bodies are required to strictly monitor water processing companies for the maintenance of the quality of bottled water.
Analysis of Long-Term Spatio-Temporal Trends in Land Use/Land Cover in Devikulam Taluk, Kerala Using Geospatial Techniques
Authors: Solanki Srishti , Chandran Chindu , Garg J.K. , Bhattacharya Prodyut
Published: December 2019

This study was undertaken to evaluate the spatial as well as the temporal changes in land use/ land cover in Devikulam Taluk, Idukki District, Kerala, and to assess the effects of increasing anthropogenic pressure on the fragile ecosystem of this area. For analysis, land use/ land cover maps of four different years, i.e., 1988, 1999, 2008 and 2017, were generated using LANDSAT TM (Thematic Mapper), ETM+ (Enhanced Thematic Mapper Plus) and OLI/TIRS (Operational Land Imager/Thermal InfraRed Sensor) satellite imagery. The results of the study suggested that there has been a drastic increase in the built-up area and a continuous decline in the forest area in Devikulam from 35.31 km2 built-up in 1988 to 73.92 km2 in 2017, and 1374.52 km2 forest in 1988 to 1247.24 km2 in 2017, respectively. Over this period of approximately 40 years, around 47.85 km2 area of the forest got converted to built-up. This could be due to the increasing anthropogenic pressure in terms of migration or booming tourism contributing to the increased demand for infrastructures. Therefore, appropriate land use planning is a fundamental step towards the sustainable development of this biogeographically rich and unique area of Devikulam Taluk.
Fictions of Obligation: Contract and Romance in Margaret Cavendish and Aphra Behn
Authors: Min Eun Kyung
Published: December 2019

This essay reads the short romances of Margaret Cavendish and Aphra Behn as complex responses to contract-based theories of obligation and the model of the political subject who enters into relationships of willing submission. Cavendish and Behn take up the subject of women’s contracts and obligations within the generic constraints of romance, but their romances belie the fiction of women freely and happily contracting with their romance heroes. Far from instancing willing submission, Cavendish’s heroines actively engage with law and go to war to subdue men who prove bad contractors and to model new forms of obligation. Behn’s romances, in contrast, teem with women who are bad contractors and whose flagrant violations of propriety and conjugality pose a sardonic challenge to conventional definitions of women’s obligations. Together, their works trouble the fiction of the willingly bound woman and attest to the diminishing power of romance to model women’s obligations in a time of continuing political crisis.
QUANDO A PALAVRA ENTRA NO TECIDO DIALÓGICO HUMANO: QUESTÕES EXISTENCIAIS EM FIÓDOR DOSTOIÉVSKI
Authors: Martins Adriana Claudia
Published: December 2019

Neste texto são consideradas as manifestações dialógicas e de caráter ético presentes na narrativa de Crime e Castigo, de Fiódor Dostoiévski. O estudo busca analisar algumas referências espaço-temporais mencionadas na obra, as quais fornecem ainda mais elementos para que compreendamos especificidades presentes na narrativa ficcional de Crime e Castigo. O texto está organizado, portanto, a partir da contextura da vida de Dostoiévski, seguido das referências espaço-temporais e paisagem petersburguense. Há, ainda, considerações acerca do personagem Raskólnikov e de sua busca de diálogo com outros personagens de Crime e Castigo na direção do reconhecimento de si. Os ambientes, o peso simbólico do cenário de São Petersburgo, a cor amarela, a sensação de viver em um caixão sem ar, as pessoas doentes, o barulho e o mau cheiro são elementos que exprimem os tormentos vividos por Raskólnikov no processo de renovação humana narrada e imbricada a Outros personagens, os quais são a possibilidade para que o protagonista seja um homem ético e renascido. É possível identificar que a tomada de consciência no movimento constitutivo de Raskólnikov nasce do encontro significativo com o Outro, quando ele toma para si as questões de sua própria existência.
A VIOLÊNCIA NO COTIDIANO DE TRABALHO DA ENFERMAGEM E OS USOS DE SI NO ENFRENTAMENTO
Authors: Fontana Rosane Teresinha
Published: December 2019

Introdução: A Organização Mundial de Saúde define violênciacomo o uso da força física ou do poder, real ou em ameaça, contra si próprio, contra outra pessoa, ou contra um grupo ou uma comunidade, que resulte ou tenha qualquer possibilidade de resultar em lesão, morte, dano psicológico, deficiência de desenvolvimento ou privação. Metodologia: Trata-se de um ensaio cujo objetivo é refletir sobre a violência psicológica sofrida pela enfermagem. Pode-se inferir que esse tipo de violência, seja perpetrada por gestores, colegas ou por usuários dos serviços de saúde é um fator determinante de sofrimento ao trabalhador. Considerações Finais: Iniciativas para o enfrentamento à violência e medidas de notificação que contribuem para o fenômeno saia da invisibilidade podem agregar valor à saúde do trabalhador de enfermagem.
THE INTEGRATED MAN AS A PRECONDITION OF HONEST BUSINESS
Authors: Kłos Jan
Published: December 2019

This paper is an attempt to depict the main preconditions of business, and honest business in particular. The author claims that in a free-market economy business is a kind of encounter between people. If such an encounter is to be effective, there must be provided some legal conditions and the human being must be integrated. By integration it is meant here a coalescence of the intellectual and moral dimensions. Thus, business is not only an economic phenomenon, but it is also humanistic and spiritual. If a dishonest person decides to do business, he will ruin all the contracts involved. Therefore contrary to what some authors claim, especially those who naively believe in the sufficient power of formal procedures, the paper holds that any person must be both intellectually and spiritually prepared for economic activity.
RUCH EKUMENICZNY WOBEC WSPÓŁCZESNYCH PRZEMIAN W SFERZE PRACY I ICH KONSEKWENCJI DLA RODZINY: DIAGNOZY I PROPOZYCJE KONFERENCJI KOŚCIOŁÓW EUROPEJSKICH
Authors: Kopiec Piotr
Published: December 2019

W opinii wielu socjologów przemiany w sferze pracy, wywołane przez gwałtowny postęp technologiczny, stają się głównym czynnikiem współczesnych przemian społecznych i kulturowych. Wśród spodziewanych negatywnych zjawisk wymienia się wzrost masowego bezrobocia technologicznego, utratę kontroli nad rozwojem sztucznej inteligencji, poszerzenie zjawiska społecznego wykluczenia, narastające rozchodzenie się prekariatu i merytokratycznej elity, a w ich następstwie pogłębiający się kryzys instytucji społecznych na czele z rodziną. Stąd też przemiany w pracy są przedmiotem refleksji teologicznej, prowadzonej również przez organizacje ekumeniczne. Wśród szczególnie aktywnych instytucji ekumenicznych należy wymienić Konferencję Kościołów Europejskich i jej komórkę – Akcja Kościelna dla Pracy i Życia, powołaną w celu poszukiwania rozwiązań rozważanego problemu. W artykule w syntetyczny sposób opisano przemiany w sferze pracy zawodowej oraz ich konsekwencje dla rodziny, społeczeństwa i kultury. Przedstawiono również szczegółowe propozycje odpowiedzi na wyzwania płynące z tych przemian, formułowane przez ekumenistów reprezentujących Konferencję Kościołów Europejskich.
WSPÓLNE KORZENIE TROSKI O STWORZENIE ORAZ O ETYKĘ RODZINNĄ
Authors: Harsányi Ottó Pál , Kopiec Maksym Adam
Published: December 2019

Część wykładu sympozjalnego pt. Wspólne korzenie etyki ekologicznej i rodzinnej, wygłoszonego na II Międzynarodowym Sympozjum Familiologicznym pt. „Biznes rodzinny w kontekście integracji nauk humanistycznych, ekonomii i gospodarki” (Uniwersytet Warmińsko-Mazurski w Olsztynie, 11–12 czerwca 2018 r.).
INSPIRACJE LABOREM EXERCENS DO REFLEKSJI NAD „GRAMATYKĄ” BIZNESU RODZINNEGO
Authors: Sambor Paweł
Published: December 2019

W jaki sposób należy ująć związek między biznesem i rodziną w rzeczywistości biznesu rodzinnego? Czy jest to relacja podporządkowania, czy też swego rodzaju komplementarności? Punktem wyjścia niniejszej refleksji jest nauczanie papieskie zawarte w encyklice Laborem exercens na temat ludzkiej pracy. Ponieważ biznes rodzinny jest wyrazem i formą pracy człowieka, należy rozpatrywać go w świetle nauczania o osobowym wymiarze ludzkiej pracy, z którego wyłaniają się trzy kręgi wartości pracy. Człowiek powinien pracować ze względu na swoje człowieczeństwo, rodzinę i społeczeństwo. Analiza teologiczna relacji między antropologicznym wymiarem pracy i powinnością moralną ze względu na bliźnich, pozwala stwierdzić, że jeśli u podstaw biznesu rodzinnego znajduje się troska o jej wymiar osobowy, gdzie w centrum nie stoją „rzeczy”, ale człowiek, wówczas rzeczywistość biznesu i rodziny nie tylko nie są sprzeczne, ale się przenikają i do siebie odwołują.
Delayed periprosthetic collection after cervical disc arthroplasty
Authors: Harris Lauren , Dyson Edward , Elliot Matthew , Peterson David , Ulbricht Christian , Casey Adrian
Published: December 2019

Cervical disc arthroplasty is a treatment option for symptomatic cervical disc disease. There is a paucity of literature on long-term safety outcomes, durability, and device-related failure rates. The M6-C artificial cervical disc is a device with titanium alloy endplates and a complex polymeric centerpiece. To date, trials have exhibited acceptable safety profiles.

This case series describes the presentation, management, and pathological findings of a delayed prevertebral periprosthetic mass anterior to the M6-C disc. Four patients at 3 different institutions underwent cervical disc replacement with the M6-C disc. Two to seven years postoperatively, they presented with dysphagia secondary to a compressive mass anterior to the disc. Case notes were reviewed to collect data on symptoms, management, and outcomes. The patients were systemically well and presented with progressive dysphagia. They had imaging findings of a mass anterior to the disc. They underwent a decompressive procedure, with 2 patients undergoing device removal and fusion. In 2 cases, a soft-tissue mass was seen intraoperatively, with frank pus. In 3 cases, Propionibacterium acnes was identified and antibiotic treatment given. Histopathology demonstrated mixed inflammatory infiltrates with foreign body–type granulomas. Postoperatively, the dysphagia resolved.

The development of delayed dysphagia in a patient with an M6-C disc should prompt investigation to identify a mass lesion. To the authors’ knowledge, this is the first report of delayed infection, or suspected delayed-type hypersensitivity reaction, following M6-C disc implantation. It is important for this to be added to the device safety concerns. Further prospective studies are needed to establish the incidence and the long-term safety and failure rates of the M6-C disc.
Development of ideas about the natural world in preschoolers with intellectual disabilities
Authors: Alabina T. V. , Shevyreva Т. V.
Published: December 2019

The article deals with the problem of formation of ideas about the plant world in preschool children with intellectual disabilities. The authors reveal the importance and formulate the importance of correction of ideas about plants in preschool children with intellectual disabilities. The article presents various scientific approaches to the problem of formation of knowledge about the world. The authors consider this problem from different angles and highlight the content and features of the work on introducing the world to preschool children with intellectual disabilities, presented in the works of scientists-defectologists. The authors come to the conclusion that it is necessary to develop a system of correction of ideas about the plant world, based on the scientific materials of the studies.
Efektivitas Penggunaan Multimedia Berbasis Macromedia Flash pada Pokok Bahasan Sistem Ekskresi untuk Meningkatkan Aktivitas Belajar dan Kemampuan Berpikir Kritis Siswa
Authors: Sugianto  , Cahyaningsih Ade
Published: December 2019

Latar belakang penelitian ini adalah bahwa aktivitas belajar siswa kurang kondusif dan proses pembelajaran yang diberikan belum berorientasi untuk mengembangkan kemampuan berpikir kritis siswa, sehingga siswa kesulitan menganalisis informasi yang ada, cenderung menerima apa adanya informasi yang disampaikan maupun yang tertulis dalam buku, dan pasif dalam mengajukan pertanyaan maupun menjawab pertanyaan dari permasalahan yang diajukan guru. Tujuan dari penelitian ini adalah untuk mengetahui keterlaksanaan, mengetahui peningkatan aktivitas belajar siswa, mengetahui peningkatan kemampuan berpikir kritis siswa, mengetahui hubungan antara aktivitas belajar siswa dan kemampuan berpikir kritis, serta untuk mengetahui respon siswa terhadap penerapan multimedia berbasis Macromedia Flash dalam pembelajaran sistem ekskresi. Aktivitas belajar siswa dinilai dengan menggunakan lembar observasi, kemampuan berpikir kritis siswa diukur dengan menggunakan tes dalam bentuk pilihan ganda, dan respon siswa dinilai dengan menggunakan lembar angket respon. Hasil penelitian menunjukan (1) keterlaksanaan penerapan multimedia berbasis Macromedia Flash memilki kriteria sedang,  (2) peningkatan aktivitas belajar siswa memiliki kriteria sangat baik, (3) penerapan multimedia berbasis Macromedia Flash dapat meningkatkan kemampuan berpikir kritis siswa, (4) terdapat hubungan yang signifikan antara aktivitas belajar siswa dengan kemampuan berpikir kritis siswa setelah diterapkan multimedia berbasis macromedia flash, (5) respon siswa terhadap penggunaan multimedia berbasis Macromedia Flash dalam pembelajaran sistem ekskresi memiliki kriteria sangat baik.
The Study of The Type Laboratory Examination in Health Service Facilities With Integration Determination of Local Content Courses DIII-Health Analys
Authors: Purjanto Kuntjoro Adi , Widiyanto S.Y Didik , Budiharjo Teguh
Published: December 2019

Introduction: Health Laboratory Services is an integral part of healthcare services to the public. The main task of health analyst conducts healthcare laboratory services. In order to produce health analyst personnel who meet the needs of graduates or stake holders, the education will apply the curriculum for the learning process. Diploma in Education 3 students must take at least 108 credits (semester credit unit). Meanwhile, the education core Curriculum 3 medical laboratory technology defined by 82 credits. In order to fulfill the credits set need to be arranged local content to meet the shortage of credits from the core curriculum that is suitable for learning access. Purpose: Obtain the amount of data on the number of laboratory tests and local subjects. Method: Secondary Data from the recording and reporting of each laboratory for 3 months. Results: A total of 48.04% clinical chemical test types. A total of 18.87% hematological examination. A total of 1.88% of parasitological and microbiological examination. A total of 19.54% of immunological examination. The curriculum that is used by the Poltekkes Department of Health analyst Semarang 108 SKS with 82 SKS core curriculum and 26 SKS local payload. The subject or number of face-to-face is based on the data proportion of three large groups of tests, namely clinical chemistry (48.04%). Immunological examination (19.54%) and hematological examination (18.87%). Conclusion: The most proportion of tests on fasyankes are clinical chemistry (48.04%). Courses "Knowledge of materials practice" could be added to the curriculum of the D3 of the Poltekkes health analyst Program in Semarang. Suggestion: Need to calculate the credits and proportion of face to face or depth to the local content course "knowledge of practice materials" and placement in the semester.
Metal Binding by GMP-1 and Its Pyrimido [1, 2]benzimidazole Analogs Confirms Protection Against Amyloid-β Associated Neurotoxicity
Authors: Kumar Rajnish , Pavlov Pavel F. , Winblad Bengt
Published: December 2019

Alzheimer’s disease (AD) represents a major public health threat and, unfortunately, available therapeutics provide only temporary symptomatic relief. AD is a complex multifactorial disease and failure of single target therapeutics targeting amyloid-β (Aβ) in recent clinical trials suggests that future AD drug development should be focused on simultaneous targeting of several pathological hallmarks of the disease. Recently, we have shown that GMP-1, a 2-(methoxymethyl)pyrimido [1, 2- a] benzimidazol-4-ol, protects mitochondrial function in drosophila and mice models of AD, and improved memory and behavior indicating neuroprotective effect of GMP-1 treatment. Here, we have found that GMP-1 specifically binds to copper and zinc, metals that are dysregulated in AD brain. Addition of GMP-1 does not inhibit metal-dependent enzymatic reactions. Also, binding of Zn(II) and Cu(II) by GMP-1 is weaker than the 8-hydroxyquinoline scaffold compound clioquinol previously tested in AD clinical trials. However, GMP-1 affects Cu(II)-dependent Aβ fibrillization as well as oxidative damage and viability of SH-SY5Y cells upon addition of Cu(II) and Aβ. Our data provide new insight on GMP-1 as a Zn(II) and Cu(II) specific metal chelator of moderate affinity that can be responsible for some of its neuroprotective effects observed in AD animal models.
Telomere Length and the Risk of Alzheimer’s Disease: The Rotterdam Study
Authors: Fani Lana , Hilal Saima , Sedaghat Sanaz , Broer Linda , Licher Silvan , Arp Pascal P. , van Meurs Joyce B.J. , Ikram M. Kamran , Ikram M. Arfan
Published: December 2019

There is a wide interest in biomarkers that capture the burden of detrimental factors as these accumulate with the passage of time, i.e., increasing age. Telomere length has received considerable attention as such a marker, because it is easily quantified and it may aid in disentangling the etiology of dementia or serve as predictive marker. We determined the association of telomere length with risk of Alzheimer’s disease and all-cause dementia in a population-based setting. Within the Rotterdam Study, we performed quantitative PCR to measure mean leukocyte telomere length in blood. We determined the association of telomere length with risk of Alzheimer’s disease until 2016, using Cox regression models. Of 1,961 participants (mean age 71.4±9.3 years, 57.1% women) with a median follow-up of 8.3 years, 237 individuals were diagnosed with Alzheimer’s disease. We found a U-shaped association between telomere length and risk of Alzheimer’s disease: compared to the middle tertile the adjusted hazard ratio was 1.59 (95% confidence interval (CI), 1.13–2.23) for the lowest tertile and 1.47 (1.03–2.10) for the highest tertile. Results were similarly U-shaped but slightly attenuated for all-cause dementia. In conclusion, shorter and longer telomere length are both associated with an increased risk of Alzheimer’s disease in the general population.
Intraperitoneal Administration of Monoclonal Antibody Against Pathologic Aβ42 Aggregates Alleviated Cognitive Deficits and Synaptic Lesions in APP/PS1 Mice
Authors: Xiao Shuo , Song Lin-Lin , Li Jiang-Tao , Wang He , Yu Na , Wang Zi-Qi , Zhang Ying , He Jin-Sheng , Hung Tao
Published: December 2019

Alzheimer’s disease (AD) is the most common form of dementia, characterized by amyloid-β peptide (Aβ) aggregates, phosphorylated tau protein ( p-tau), and progressive neurodegeneration. Amyloid-β peptide 42 (Aβ42) is considered an early trigger of AD pathogenesis. We have previously reported that Aβ N-terminus monoclonal antibody (mAb) A8 alleviated cognitive dysfunction and reduced the abundance of soluble Aβ in the brains of the senescence-accelerated mouse prone 8 (SAMP8) mouse model. To confirm the efficacy of mAb A8 in the double-transgenic APPswe/PS1 ΔE9 (APP/PS1) mice, here we reported the related findings. The Morris water maze (MWM) data showed that the A8 treatment group had a shorter escape latency than the control groups in the place navigation test and the probe trial ( p < 0.05). Moreover, immunohistochemistry showed decreased levels of both Aβ and p-tau in the brains of APP/PS1 mice. Regarding Aβ levels, western blot results showed that Aβ42 oligomer ( p < 0.01) but not Aβ40 levels were diminished in brains of A8-treated APP/PS1 mice. Western blot results showed that phospho-tau (pSer231) ( p < 0.01) but not tau levels were reduced in A8-treated mouse brains. Furthermore, transmission electron microscopy images indicated ultrastructural improvements, including an increased ( p < 0.01) density of synapses and a reduction of abnormally enlarged mitochondria ( p < 0.01), in the brains of A8-treated mice. Taken together, our data showed that mAb A8 is highly efficacious in APP/PS1 mice as a treatment for AD, and the underlying mechanism may target synaptic pathology by inhibiting the amyloid cascade.
Medium-to-High Late-Life Physical Activity Is Associated with Lower Risk of Incident Dementia: The Shanghai Aging Study
Authors: Wu Wanqing , Ding Ding , Zhao Qianhua , Wang Ruru , Liang Xiaoniu , Xiao Zhenxu , Luo Jianfeng , Guo Qihao , Hong Zhen
Published: December 2019

Background:

There is significant evidence that physical activity has profound effects on the neurochemistry and plasticity of the brain and may prevent cognitive decline.

Objective:

This study aimed to determine the association between physical activity and incident dementia among older Chinese adults.

Methods:

In the prospective phase of the Shanghai Aging Study, 1,648 community-dwellers aged 60 years or older were followed for an average of 5 years. Their physical activity was assessed based on questionnaires. The physical activities were further transformed into metabolic equivalent values. A consensus diagnosis of incident dementia was ascertained based on medical, neurological, and neuropsychological data and the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition.

Results:

We identified 166 incident dementia cases; the incidence rate was 19.4 per 1000 person-years. A multivariate Cox regression model indicated that compared to low levels of physical activity, medium-to-high levels of physical activity were associated with a reduced risk of dementia (hazard ratio, 95% confidence interval = 0.62, 0.44–0.89) after adjusting for age, sex, years of education, apolipoprotein E ɛ4, and other confounders.

Conclusion:

Our findings demonstrate that medium-to-high level of physical activity is protective against dementia in older adults.
Ethics of faith
Authors: Polischuk M.
Published: December 2019

It sometimes seems to me that I have a certain gift of foresight as to whether the promise promised by our President will come true or not. For example, if the President says that he will move to a new apartment, I believe his words. If he says that he will take the skyscraper to the base in the Mariinsky Park to the base, I already know ahead of time: no, it will not. On the contrary, after some hype, this house will still be completed and settled, and among the new residents there will be many employees of the Presidential Secretariat. If the guarantor says that no more corrupt officials will be able to hide from law enforcement agencies, I question these words. But the fact that in schools, at the request of the President from the new school year, will introduce an item called "Ethics of Faith", I believe unconditionally.
Experience teaching Christian ethics in a secular school
Authors: Sannikova T.
Published: December 2019

The spiritual and moral crisis in society, which is a sign of the loss of clear ideas about good and evil, when the ideal of a person becomes "successful in human life" and no matter how successful it becomes, when moral laws and human life are worthless, needs urgent return to spiritual sources. As one of the means of spiritual education of adolescents, a Christian ethics elective was introduced at the secondary school №26 in Odessa.
Export performance and competitiveness in wood products in the Czech Republic and Austria
Authors: Verter Nahanga , Grega Libor
Published: December 2019

This article assesses the
development of wood exports in the Czech
Republic (Czechia) and Austria in recent years. Some approaches, such as revealed
comparative advantage (RCA), relative trade balance index (RTB), and diversification
ratios are used to assess the export performance and competitiveness
indicators in these countries. The RCA result reveals that both Czechia and
Austria have been competitive in the global wood markets, just as the countries
have witnessed positive in RTB within the period under study. Market diversification
results indicate that both countries concentrated in few markets (mainly within the EU single market) for exports
of wood products. Also, the competitiveness based on the product structure
shows that both countries, notably
Austria wood product groups have been diversified and mostly processed before exports. In
summary, both countries have performed impressively within the period
under study even though the time series for the research was short. Nevertheless,
there is a need for market export diversification beyond the EU’s single
market.
Kajian Azaz Manfaat Jembatan Penyeberangan Orang (JPO) di Jalan Sultan Thaha Kota Jambi
Authors: Yamali Fakhrul Rozi
Published: December 2019

Pedestrian facilities are often overlooked. Whereas pedestrians include elements of traffic flow that need attention, especially in dense urban areas will be vehicles. The purpose of this research is to know the benefits of the Pedestrian Overpass (JPO) in Jalan Sultan Thaha near WTC Mall of Jambi City. The research conducted is to survey JPO users during peak hours and busy days and compare to the traffic in the research area. The results of the study assessed the suitability of the ferry facilities to the existing requirements and to recommend appropriate facilities can be calculated from the highest crossing volume (P) and vehicle volume (V) at peak hours ie P = 325 pedestrians /hour, V = 2610.75 vehicles./hour. Based on the recommendation of choosing a road crossing facility, it can be concluded that the recommended facilities are Zebra Cross (ZC) crossing facilities and it is not feasible to use JPO. From the percentage data of population growth in the estimation of the number of people who will use pedestrian overpass, it will work at 8 years 3 months ahead. Keyword :  Pedestrian Overpass, Crossers, traffic density
Analisis Kekuatan Jembatan Konstruksi Baja Sungai Merangin Teluk Wang
Authors: Nuklirullah M , Siregar Erwin
Published: December 2019

Merangin Regency has many natural beauty and has various tourist attractions. One of them is Wang waterfall which is located in Biuku Tanjung village. To get to the object, once visitors must cross the river by boat. But now the government has built a pedestrian bridge with a span 48 meters to the waterfall tourist attractions, making it easier for visitors. Every year the visitors are growing. The purpose of this study is to analyze the strength of the bridge that is in the tourist attraction. Load and Resistance Factor Design (LRFD) method used in analyzing bridges with 2 dimensional structure modeling in the form of portal structure. The data in this research is primary data obtained with direct observation and measurement of field and secondary data is drwing plan of bridge. From the results of structural calculation analysis, all of the planned dimensions meet the strength and security requirements of the structure.Key words : Steel Structure, pedestrian bridge, LRFD method
试论全过程工程造价在建筑经济管理中的重要
Authors: 王 富国
Published: December 2019

在社会快速发展的影响下，使得我国各个行业得到了显著的进步，尤其是建筑行业的发展十分的迅速。一个完整的建筑工程项目涉及到：规划、设计、施工、验收、管理等众多环节，工作量的繁多往往会对建筑经济管理工作的落实造成严重的困扰，如果缺少专门的造价管理方法，势必会造成严重的经济损失的情况发生。这篇文章主要围绕全过程造价在建筑经济管理工作的作用展开全面的分析研究，希望对整个建筑行业的稳定健康发展有所助益。
城市社区街道环境美化中浮雕艺术的应用
Authors: 张 可松
Published: December 2019

当前人民生活步入全面小康，对美好生活的向往、需求更多体现在文化艺术方面。居住环境的改造和美化建设迅速发展，在城市社区街道环境美化改造建设中，墙体已有原来的建筑结构功能，逐渐发展到具有景观艺术美化功能。在环境美化过程中墙体利用浮雕艺术形式进行装饰，能够营造公共空间的文化艺术性，改善居民生活环境面貌，建设社区文化，让人民文化艺术需求得到实现。
关于建筑钢结构工程设计及其注意事项的探析
Authors: 王 献春
Published: December 2019

建筑钢结构工程的设计工作关系到建筑整体的安全及使用质量，因此必须在进行钢结构设计的过程中把握好相关原则及注意事项。结合自身的工作经验，分析了建筑钢结构工程的常用设计方法，包括容许应力法、极限状态法、塑性设计法等方法，在具体的方案设计过程中，需要在注意适宜性、注意钢结构材料的合理选择、注意细节部分设计、注意防火设计、加强钢结构设计的抗震能力、考虑高层建筑整体性等方面做好质量控制。
分析倾斜摄影测量技术在不动产测绘中的应用
Authors: 戴 兵
Published: December 2019

在最近的几年时间里，我国的科学技术水平得到了显著的提升，从而使得大量的新型科学技术被研发出来，并被人们大范围的运用到了各个领域之中，取得了非常显著的成效。其中倾斜摄影测量技术就是其中之一，其实质是以同一个物体为对象，运用多个传感设备来协调工作，能够在最短的时间内获得更多的数据，将物体的现实情况加以呈现，这种方法能够有效的缓解航拍技术中存在的问题，确保数据测量工作的准确性，具备良好的实用性。
SOCIO-PSYCHOLOGICAL CHARACTERISTICS OF PATIENTS WITH SCHIZOPHRENIA RECEIVING COMPULSORY INPATIENT AND OUTPATIENT TREATMENT AND VOLUNTARY PSYCHIATRIC PATIENTS
Authors: Boltivets Sergii , Chelyadyn Yuliya , Gonchar Tymur , Uralova Lyudmila , Bashinskii Oleksandr
Published: December 2019

The aim of the research was to obtain data for scientific justification and development of an algorithm of medico-social rehabilitation for patients with schizophrenia under compulsory out- and inpatient treatment. During the research clinical and social-demographic conditions were evaluated for the chosen group of people currently undergoing coercive treatment and for the control group. The role of the clinical-psychopathological and social-environmental agents that caused patients compulsory hospitalization was determined. The level of social functioning and the dissocializing factors were evaluated.
Keywords: schizophrenia, coercive treatment, social-psychological characteristics.
Status žena u podunavskim zajednicama u starijem željeznom dobu
Authors: Ložnjak Dizdar Daria
Published: December 2019

Starije željezno doba na prostoru istočne Slavonije, zapadne Bačke i zapadnoga Srijema naseljavale su zajednice koje se povezuju s materijalnom kulturom grupe Dalj. Kontinuitet u naseljavanju i pokopavanju na istim položajima može se pratiti od kasnoga brončanog doba. U novim istraživanjima groblja iz kasnoga brončanog i starijega željeznog doba u Sotinu pronađeno je 119 grobova. Radi se o paljevinskim grobovima, pri čemu su spaljeni ostaci pokojnika s ostacima nošnje i osobnim predmetima u većini grobova bili položeni u žare te poklopljeni zdjelom u funkciji poklopca. U grobovima starijega željeznog doba bili su položeni i keramički servisi sastavljeni od lonaca, šalica, kantharosa i zdjela koji su sadržavali piće i jelo – popudbinu u pogrebnome ritualu. Interdisciplinarne analize konteksta, nalaza i uzoraka omogućavaju detaljnije interpretacije pogrebnih običaja, identiteta i statusa pokojnika kroz analizu pojedinačnih grobova. Siguran kontekst u kojem su povezani keramički nalazi i nakit omogućavaju i detaljnije datacije inventara unutar starijega željeznog doba na prostoru Podunavlja, sagledanoga u mreži komunikacija i utjecaja vidljivih na predmetima i u pogrebnim običajima.
Álvarez Conde, Enrique: «Reforma constitucional y reformas estatutarias» (Recensión)
Authors: Merino Merchán José Francisco
Published: December 2019

Recensión sobre la reforma constitucional y reformas estatutarias
Bibliografía sobre la reforma de los Estatutos de Autonomía
Authors: García de la Oliva África , Juliani Aguado Mercedes
Published: December 2019

Notas y reflexiones sobre la reforma de los Estatutos de Autonomía (Bibliografía)
Constitución de la República de Hungría
Authors: Sieira Mucientes Sara
Published: December 2019

Reflexión sobre la Constitución de la República de Hungría
La reforma de la Ley Orgánica de Régimen Electoral General por Ley Orgánica 9/2007, de 8 de octubre
Authors: Sáenz Royo Eva
Published: December 2019

La Reforma de la Ley Orgánica de Régimen Electoral General por Ley Orgánica 9/2007, de 8 de Octubre
Tratado de Lisboa. Texto consolidado del Tratado de la Unión Europea, Protocolos, Anexos y Declaraciones relativas a la disposiciones de los Tratados, a los Protocolos anejos a los Tratados y Declaraciones de los Estados Miembros
Authors: Unión Europea Consejo de la UE
Published: December 2019

Texto Consolidado del Tratado de Lisboa
Entre la utopía y el posibilismo : el Tratado de Lisboa y el espacio de libertad, seguridad y justicia
Authors: Gortázar Cristina
Published: December 2019

Reflexiones sobre el Tratado de Lisboa y el espacio de libertad, seguridad y justicia de la Unión europea
José Manuel Cuenca Toribio: «Nacionalismo, Franquismo Y Nacionalcatolicismo» (Recensión)
Authors: Martín de la Guardia Ricardo
Published: December 2019

Recensión sobre «Nacionalismo, Franquismo y Nacionalcatolicismo»
Propuesta de desarrollo del nuevo trámite de admisión del recurso de amparo : aspectos materiales y procedimentales
Authors: Hernández Ramos Mario
Published: December 2019

SUMARIO: Introducción. 1) Punto de partida: planteamiento de la situación. 2) Los referentes de Derecho comparado: a) El Tribunal Supremo Federal de los Estados Unidos de América. b) El Bundesverfassungsgericht de la República Federal de Alemania. 3) El nuevo modelo de admisión español: propuesta de desarrollo. 3.1) Planteamiento de la propuesta de desarrollo. 3.2) Aspectos materiales: el desarrollo del concepto de «especial trascendencia constitucional». a) Planteamiento. b) Interpretación del art. 50.1.b) LOTC primer y tercer criterio hermenéutico. c) Interpretación del art. 50.1.b) LOTC segundo criterio hermenéutico. d) La función subjetiva del recurso de amparo como criterio de admisión. 3.3) Aspectos procesales del trámite de admisión y tramitación interna de los recursos por parte del Tribunal Constitucional: clave del éxito de la reforma. Anexo: Datos estadísticos sobre la situación de sobrecarga de trabajo del tribunal constitucional.
La Guerra de la Independencia y los americanos españoles en los documentos de la colección Gómez de Arteche : Biblioteca del Senado
Authors: González del Campo María Isabel
Published: December 2019

SUMARIO: I. II. INTRODUCCIÓN. 1. La propagenda y la guerra. 2. La guerra, vista desde América. 3. Documentos relacionados con América, en la colección Gómez de Arteche. II. PROCLAMAS Y MANIFIESTOS LLAMANDO AL PATRIOTISMO. «BATALLAR CON LAS LETRAS». A) Primera etapa. De 1808 a 1810. B) Segunda etapa. De 1811 a 1814. III. PETICIONES DE AYUDAECONÓMICAPARALUCHAR CONTRA NAPOLEÓN. A) Respuesta de México. B) Curioso procedimiento para recaudar fondos. IV. CONVOCATORIA A CORTES. ELECCIÓN DE DIPUTADOS. A) Cortes Generales y extraordinarias. 1810-1813. B) CORTES 1813-1814. V. CONCLUSIÓN.
Nota para la Ponencia del Proyecto de Ley del Gobierno
Authors: Ripollés Serrano María Rosa
Published: December 2019

Nota para la Ponencia del Proyecto de Ley del Gobierno
IV OPP Congress | Book of Proceedings | Braga, 2018
Authors: IV OPP Congress, 2018 Scientific Committee
Published: December 2019

This proceedings book integrates the collection of short papers that have been submitted and accepted by the Scientific Commitee of the 4th Congress of OPP, venued in Braga, between the 12th and 15th September 2018, under the scope of: Psicologia na Prevenção e Promoção do Desenvolvimento das Pessoas, Coesão Social e Crescimento Económico.
Поняття та особливості адмінстративних процедур
Authors: Ігонін Р. В. , Вікторчук М. В.
Published: December 2019

У статті розглянуто особливості адміністративних процедур як правового явища, визначено поняття «адміністративна процедура», проаналізовано ознаки адміністративних процедур. Проаналізовано наукові підходи щодо розмежування понять «адміністративна процедура», «адміністративний процес» та «адміністративне провадження». Зроблено висновок, що адміністративний процес є одним з видів правового процесу, і охоплює діяльність суб’єктів права щодо здійснення правового регулювання суспільних відносин і реалізації норм права.
Заборона дискримінації на носіння релігійних символів в судовій практиці європейських регіональних судів
Authors: Животовська І. Ю.
Published: December 2019

У статті автор аналізує прецедентну практику Суду Європейського Союзу, спрямованого на розгляд справ щодо носіння працівниками релігійних символів на робочому місці (Achbita v G4S Secure Solutions NV та Bougnaoui v Micropole SA), які стосуються релігійної дискримінації відповідно до Директиви про рівне ставлення 2000/78/ЄС. Згідно з міжнародними конвенціями з прав людини, прагнення приватної компанії до нейтральної політики не може бути привідом для обмежень права на свободу віросповідання працівника на робочому місці. Проте Суд встановив, що за відповідних обставин компанія має право на ведення такої політики, результат якої спричиняє на практиці негативні наслідки для значної частини суспільства ─ особливо для мусульман, сикхів та іудеїв, які стикаються з проявами дискримінації при працевлаштуванні. Особлива увага у статті приділяється досвіду Європейського Суду з прав людини при розгляді аналогічних справ.
Щодо суб’єктів, які мають право судового захисту трудових прав
Authors: Любчик О. А.
Published: December 2019

У статті проаналізовані наукові погляди щодо суб’єктів, які мають право на судовий захист трудових прав. Особлива увага приділяється трудовому колективу як суб’єкту права на судовий захист трудових прав: його особливостям участі у правовідносинах та проблемах, пов’язаних із реалізацією ним цих повноважень. Також сформульовані конкретні аргументовані пропозиції щодо вдосконалення законодавчого регулювання з цих питань
Водії зі стажем до двох років – фактор високого ризику дорожньо-транспортних пригод в Україні
Authors: Болоташвілі З. У.
Published: December 2019

Метою статті є розгляд правових відносин при управлінні механічними транспортними засобами водіями із стажем до двох років (далі водіями новачками) в Україні й пропозиція правових шляхів зниження дорожньо-транспортних подій, а також ризику загрози життя, здоров'ю учасників дорожнього руху (водіїв, пішоходів, пасажирів, велосипедистів і мотоциклістів) шляхом коригування розділу "Обов'язку і права водіїв механічних транспортних засобів" справжніх правил дорожнього руху України.