bluuebunny/crossref_metadata_2025 huggingface dataset:
Murs et caravanes. Les migrants centraméricains à Tijuana en décembre 2018
Authors: Lestage Françoise
Published: November 2019

Reportage sur le vif d’une « caravane » de migrants centraméricains arrivés à Tijuana (Basse Californie, Mexique) en décembre 2018, ce texte fournit quelques informations chiffrées sur le millier de personnes accueillies dans le centre d’hébergement de El Barretal et sur leur quotidien dans ce lieu que la municipalité leur a dédié du 28 novembre 2018 au 29 janvier 2019. Il évoque un moment d’espoir pour les membres des caravanes puisque le gouvernement mexicain, dirigé par un nouveau président, André Manuel Lopez Obrador, leur offrait la possibilité de travailler et de s’installer temporairement au Mexique et promettait d’aider leurs pays d’origine. Comme le signale le chapeau du texte, cet espoir a été brutalement détruit par le revirement politique radical du printemps 2019 qui a entraîné la fermeture de la frontière sud du Mexique, accompagné d’une criminalisation et d’un enfermement des migrants centraméricains auxquels le pays avait ouvert les bras quelques mois plus tôt.
Politique et environnement dans la Moskitia nicaraguayenne (1960-2018)
Authors: Bataillon Gilles
Published: November 2019

Comment comprendre les rapports entre politique, environnement et territoire dans la Moskitia Nicaraguayenne ? Ce territoire symbolise la situation paradoxale des peuples amérindiens en ce début de XXI e  siècle. On constate à la fois un large mouvement de reconnaissance des droits des populations autochtones, notamment au travers de la Convention (n° 169) relative aux peuples indigènes et tribaux adoptée en 1989 par L’Organisation internationale du travail qui consacre les droits fonciers des peuples autochtones, et dans le même temps une avancée des fronts agricoles ou miniers qui atteignent des régions jusqu’alors isolées. Dans tous les pays d’Amérique latine, on a assisté à la multiplication de conflits fonciers et environnementaux, conflits qui ont été de pair avec des phénomènes de corruption sans précédents par leur ampleur. La situation que connaît aujourd’hui la Moskitia et ses habitants symbolise au mieux la complexité du sort des populations indiennes au début du XXI e  siècle.
Experiencing the Effect of Teaching and Learning Styles on Skill Mastery
Authors: Bender Denise G.
Published: November 2019

Experiencing the Effect of Teaching and Learning Styles on Skill Mastery

In cooperative group learning, students work together to gather and learn information about a particular topic. This teaching method uses the adult learning principles of group collaboration and shared knowledge to encourage students to take an active role in learning (Lee, 2001). Cooperative learning requires students to assume responsibility for participating in the information-acquisition and information-processing roles to master the assigned material (Cortright, Collins, & DiCarlo, 2005). [more...]
The Nature and Frequency of Outer Retinal Disruption in Idiopathic Multifocal Choroiditis Associated With Persistent Fundus Hyperautofluorescence
Authors: Kaden Talia R. , Gattoussi Sarra , Dolz-Marco Rosa , Balaratnasingam Chandrakumar , Yannuzzi Lawrence A. , Freund K. Bailey
Published: November 2019

BACKGROUND AND OBJECTIVE:

To describe the prevalence and anatomic correlates for hyperautofluorescence related to outer retinal disruption in eyes with multifocal choroiditis (MFC).

PATIENTS AND METHODS:

Retrospective review of MFC patients.

RESULTS:

Fifty-nine eyes from 37 patients were analyzed. Multimodal imaging was utilized to identify nine eyes (15.2%) of six patients with either transient (Group 1) or persistent (Group 2) regions of hyperautofluorescence associated with ellipsoid zone (EZ) disruption over intact retinal pigment epithelium (RPE). Group 1 included four eyes (6.8%) of three patients in which the hyperautofluorescence and EZ loss resolved within a few months (range: 28 days to 125 days) and had intact overlying outer nuclear (ONL) and outer plexiform layers (OPL) (mean follow-up: 1.3 years). Group 2 included five eyes (8.5%) of three patients with regions of permanent EZ disruption associated with absent or reduced ONL and OPL (mean follow-up: 4.6 years).

CONCLUSIONS:

Hyperautofluorescence correlating with EZ disruption over intact RPE is a rare occurrence in MFC. Evaluating outer retinal integrity by optical coherence tomography may help identify eyes with potential for EZ restoration, which may have implications regarding treatment strategies.

[
Ophthalmic Surg Lasers Imaging Retina.
2019;50:675–683.]
Correlation of Macular Thickness and Visual Acuity in DME Treated by Two Doses of Intravitreal Ziv-Aflibercept Versus Bevacizumab: Analysis of a Randomized, Three-Armed Clinical Trial
Authors: Jabbarpoor Bonyadi Mohammad Hossein , Baghi Ahmadreza , Ramezani Alireza , Yaseri Mehdi , Soheilian Masoud
Published: November 2019

BACKGROUND AND OBJECTIVE:

To report the correlation of central macular thickness (CMT) and best-corrected visual acuity (BCVA) after 1-year treatment by two doses (2.5 mg or 1.25 mg) of intravitreal ziv-aflibercept (IVZ) versus bevacizumab (IVB) in eyes with diabetic macular edema (DME).

PATIENTS AND METHODS:

In this study, the correlation of CMT and BCVA changes of the eyes enrolled in a previous clinical trial of 123 eyes were re-evaluated. The correlation of BCVA and CMT changes at each visit was evaluated in the three study arms individually. Then, the eyes in each of the arms were classified at each follow-up visit into three subgroups based on their CMT changes related to the baseline CMT: CMT decrease of 30% or more of baseline CMT, between 10% to 29% of baseline CMT, and less than 9% of baseline CMT or CMT increase.

RESULTS:

BCVA and CMT changes were correlated significantly (
P
< .05) in all and in half of the follow-up visits, respectively, in the eyes treated by IVZ 1.25 mg and IVB (r = 0.554 and r = 0.617 at 1 year, respectively). Nevertheless, such a significant correlation was not detected in the eyes treated by IVZ 2.5 mg in any of the follow-up visits (r = 0.202 at 1 year;
P
= .259). In the IVZ 2.5 mg group, BCVA improvement was observed in all subgroups with each level of CMT reductions.

CONCLUSION:

Ziv-aflibercept 2.5 mg might have a beneficial effect on DME beyond thickness reduction.

[
Ophthalmic Surg Lasers Imaging Retina.
2019;50:684–690.]
Elimination of a False-Negative Result With the M-CHARTS Metamorphopsia Assessment Tool Achieved Through Sampling Oblique Axes
Authors: Lifton Jacob A. , Moshfeghi Andrew A.
Published: November 2019

Standard implementation of the M-CHARTS metamorphopsia tool presents patients with only vertical and horizontal lines, potentially overlooking distortions not occurring within those precise meridians. The authors propose rotating the M-CHARTS testing booklet about the central fixation point until maximal distortion is perceived, after which sequential M-CHARTS testing can take place along that same axis. In a symptomatic patient with residual parafoveal fluid cysts after release of vitreomacular traction, M-CHARTS testing yielded standard testing scores of 0 (false-negative); upon rotating the reference test line, a score of 0.3 was measured at the 30° meridian. The authors believe this modification of the original methodology is more sensitive and more accurately reflects the severity of a patient's distortions.

[
Ophthalmic Surg Lasers Imaging Retina.
2019;50:734–736.]
Screening for Myopia-Related Retinal Changes Among Teenagers
Authors: Allon Gilad , Machluf Yossy , Mezer Eedy , Chaiter Yoram
Published: November 2019

BACKGROUND AND OBJECTIVE:

To evaluate the relationship between spherical equivalent (SE) refractive error and myopia-related peripheral retinal changes (MPRCs) and to find the optimal cutoff for screening myopic teenagers.

PATIENTS AND METHODS:

The study included 2,286 myopic subjects who had a dilated fundus examination between 1998 and 2011 and SE of −4.0 diopters (D) or higher in both eyes.

RESULTS:

Ninety-five subjects (4.16%) had MPRCs. Two subjects (0.09%) had moderate-to-severe MPRCs. A significant correlation (
P
< .0001) between SE and MPRC was found. The highest sum of sensitivity (72.63%) and specificity (73.44%) was achieved when a SE of −6.25 D in the more myopic eye was utilized as the cutoff.

CONCLUSIONS:

SE and MPRCs are highly associated. The optimal cutoff to detect MPRC in teenagers is −6.25 D. However, using a SE of −4.0 D as the cutoff may be the practical choice for screening due to the noninvasiveness nature and low cost of the examination.

[
Ophthalmic Surg Lasers Imaging Retina.
2019;50:e311–e319.]
Sesgo tafonómico en los datos de distribución de Cloudina en Siberia
Authors: Markov G. , Rogov V. , Karlova G. , Grazhdankin D.
Published: November 2019

En Siberia los morfotipos de Cloudina han sido tradicionalmente considerados como una variedad tafonómica de conchas de Anabarites, insertadas una dentro de otra, bajo condiciones hidrodinámicas específicas. Las asociaciones de conchas cónicas telescópicas son omnipresentes en el Grupode Kessyusa y en estratos contemporáneos a lo largo de Siberia, y no todos ellos pueden ser fácilmente interpretados como resultado de un simple apilamiento mecánico. Queda por ver si alguna de estas bioacumulaciones representa una asociación de vida de una estructura morfotípica de tipo Cloudina.
Didactic Simulations for Electromagnetism Based on an Element Oriented Model
Authors: Salmi Khalid , Magrez Hamid , Ziyyat Abdelhak
Published: November 2019

The web has spurred our imagination as to how education can be drastically transformed and improved through the adoption of Information and Communications Technology (ICT) and the use of simulations quickly became a wildly disputed topic. This kind of simulations are considered as a significant pedagogical innovation especially in the electromagnetics course where it is possible to concretize , via a set of interactive simulations, some experiments that are inaccessible in real life. The aim of interactive simulations is to enhance the student’s understanding by providing him a meaningful insight into the studied notions, phenomena, concepts, laws and models. The design of didactic simulations is constrained by both technological choices, learning theories and numerical models which should guarantee a minimal execution time, a better stability and an acceptable precision. Our goal in this work is to design didactic simulations for electromagnetism using a numerical Element Oriented Method (EOM). The proposed EOM meets the needs of speed, accuracy and ensure bet-ter dynamical and visual interpretations of the basic laws of electromagnetic. Moreover, these applications are not only available for traditional training in the classroom but also for new training platforms provided by digital technologies such as web-based training, e-learning and m-learning.
ICTs and Geometry
Authors: Galitskaya Viktoriya , Drigas Athanasios
Published: November 2019

The purpose of this paper is to present researches on how to teach students Geometry through ICTs methods from 2014 to 2019. The articles were searched through Google Scholar. At first, the focus of the article is on the teaching of geometry with software available on the Internet for PCs. Sec-ondly, educational games for geometry are presented that a student can in-stall on any device, such as a smartphone or tablet and are available to the user at any time. Almost all of the described researches have tested the ef-fectiveness of ICTs teaching methods for geometry in relation to classical teaching methods such as paper-and-pencil. Based on findings, the teaching of geometry with ICTs had better educational results than the paper-and-pencil method of teaching.
Are Computer Experience and Anxiety Irrelevant? Towards a Simple Model for Adoption of E-Learning Systems
Authors: Hanif Aamer , Siddiqi Ahmed Faisal , Jalil Zunera
Published: November 2019

Massive growth of technology based e-learning systems is enabling student access to academic content from higher education institutions around the world. This study explores the antecedents of behavioral intention of students to use e-learning systems in university education to supplement classroom learning. A quantitative approach involving a structural equation model is adopted and research data collected from 358 undergraduate students is used for analysis. The study framework is based upon the technology acceptance model (TAM) and three external factors are proposed to influence the behavioral intention of students to use e-learning. Frequently used external factors in previous researches like computer experience and anxiety were not used and alternate factors were explored. Results show that self-efficacy, enjoyment and results demonstrability have a significant positive influence on perceived usefulness and on perceived ease of use of the e-learning system. The study contributes to understanding such contributory factors from the viewpoint of a student by suggesting that these factors hold well in the Pakistani academia culture where sufficient relevant empirical evidence did not exist due to lack of prior studies.
La toiture en remploi : charpente et couvertures de la cathédrale Saint-Pierre de Lisieux
Authors: Aumard Sylvain , Épaud Frédéric
Published: November 2019

En préalable d’un chantier de restauration des toitures de la cathédrale Saint-Pierre de Lisieux, une étude a été réalisée sur la charpente du déambulatoire ainsi qu’une évaluation du potentiel
archéologique de l’ensemble des couvertures de l’édifice. Étudiés auparavant, les ouvrages coiffant le grand comble
datent de la fin du xiie et du début du xiiie siècle, formant un des ensembles les
mieux conservés pour cette période. Le relevé et les datations dendrochronologiques ont montré que la charpente du déambulatoire fut
entièrement reconstruite en 1763 en réemployant de nombreux bois des
charpentes antérieures, dont celle d’origine, à demi-fermes et pannes,
datée de 1218. Les autres réemplois témoignent d’un premier
remaniement des toitures du déambulatoire en 1380, et d’un second en 1437-1442. Par
ailleurs, l’examen systématique des couvertures a montré que les
toitures de la nef et du bras nord du transept conservaient encore
plusieurs milliers de tuiles médiévales. Dépourvues de crochet, ces dernières sont dans leur grande majorité simplement
dotées de larges perforations et d’un pureau glaçuré. Leur datation
n’est pas établie, mais la fin du xiie et
le début du xiiie siècle sont fortement
envisagés. Avec les charpentes, il s’agirait actuellement d’un des
corpus archéologiques les mieux préservés pour appréhender la
connaissance des couvertures médiévales en contexte monumental.
Learner Perceptions of Open Pedagogy in a Psychology Course
Authors: Sheu Feng-Ru
Published: November 2019

A research and course re-design project was undertaken to document, evaluate, and report the effects of implementing an OER-enabled pedagogy project in a psychology course within Georgia Southwestern State University. The project involved redesigning alternative and ‘renewable assignments' in a course using open textbooks to replace some paper writing assignments that are ‘disposable.' Data was gathered from 42 students enrolled in the course, including surveys, student reviews, and instructor feedback. Results indicated that students prefer the renewable assignments, which helped them better understand the content and prepare for the exams. They also like to be involved in the decision process, such as the choice of assignment, including the questions they created in the exams. Feedback from instructors indicated that effort and time was about the same or slightly more effective in terms of course preparation, implementation, and student performance. However, students' engagement was increased, and improvements can certainly be made for next semester.
Towards an Integrated Electronic Medical Records System for Quality Healthcare in Ghana
Authors: Gyaase Patrick Ohemeng , Darko-Lartey Richard , William Harrison , Borkloe Foster
Published: November 2019

This article explores the factors militating against the diffusion integration electronic medical records in Ghana. Structured questionnaires were used to collect data from respondents in the healthcare ecosystem and analyzed quantitatively using descriptive and inferential statistics. The findings revealed non-integration of electronic medical records systems among the stakeholders of the healthcare ecosystem mostly due to and interoperability issues. There is also substantial usage of technology in capturing and storing medical records. The key factors militating against the integration of electronic medical records systems are inadequate funds to purchase database management systems, acquisition and maintenance costs of electronic medical records systems, and an unclear return on investment on the integrated electronic medical records systems. The article recommends sustained government financial support, standardization policy and implementation guidelines to facilitate the integration of electronic medical records systems in the various health institutions.
Strategies of Virtual Screening in Medicinal Chemistry
Authors: Passeri Giovanna Ilaria , Trisciuzzi Daniela , Alberga Domenico , Siragusa Lydia , Leonetti Francesco , Mangiatordi Giuseppe F. , Nicolotti Orazio
Published: November 2019

Virtual screening represents an effective computational strategy to rise-up the chances of finding new bioactive compounds by accelerating the time needed to move from an initial intuition to market. Classically, the most pursued approaches rely on ligand- and structure-based studies, the former employed when structural data information about the target is missing while the latter employed when X-ray/NMR solved or homology models are instead available for the target. The authors will focus on the most advanced techniques applied in this area. In particular, they will survey the key concepts of virtual screening by discussing how to properly select chemical libraries, how to make database curation, how to applying and- and structure-based techniques, how to wisely use post-processing methods. Emphasis will be also given to the most meaningful databases used in VS protocols. For the ease of discussion several examples will be presented.
The Role of Artificial Intelligence in Clinical Decision Support Systems and a Classification Framework
Authors: Walczak Steven
Published: November 2019

Clinical decision support systems are meant to improve the quality of decision-making in healthcare. Artificial intelligence is the science of creating intelligent systems that solve complex problems at the level of or better than human experts. Combining artificial intelligence methods into clinical decision support will enable the utilization of large quantities of data to produce relevant decision-making information to practitioners. This article examines various artificial intelligence methodologies and shows how they may be incorporated into clinical decision-making systems. A framework for describing artificial intelligence applications in clinical decision support systems is presented.
A Secure Robust and Privacy Enhanced Mobile Healthcare Framework
Authors: Alsaghier Hisham M. , Ahamad Shaik Shakeel
Published: November 2019

This article describes how the exponential growth of mobile applications has changed the way healthcare services function, and mobile healthcare using the Cloud is the most promising technology for healthcare industry. The mobile healthcare industry is in a continuous transition phase that requires continual innovation. There has been identified some of the challenges in the area of security protocols for mobile health systems which still need to be addressed in the future to enable cost-effective, secure and robust mobile health systems. This article addresses these challenges by proposing a secure robust and privacy-enhanced mobile healthcare framework (SRPF) by adopting a Community Cloud (CC), WPKI cryptosystems, Universal Integrated Circuit Cards (UICCs) and a Trusted Platform Module (TPM). All the security properties are provided within this framework. SRPF overcomes replay attacks, Man in the Middle (MITM) Attacks, Impersonation attacks and Multi-Protocol attacks as SRPF was successfully verified using a scyther tool and by BAN logic.
Detecting Human Diseases Relatedness
Authors: Fathalla Said
Published: November 2019

Due to the ubiquitous availability of the information on the web, there is a great need for a standardized representation of this information. Therefore, developing an efficient algorithm for retrieving information from knowledge graphs is a key challenge for many semantic web applications. This article presents spreading activation over ontology (SAOO) approach in order to detect the relatedness between two human diseases by applying spreading activation algorithm based on bidirectional search technique. The proposed approach detects two diseases relatedness by considering semantic domain knowledge. The methodology of the proposed work is divided into two phases: Semantic Matching and Diseases Relatedness Detection. In semantic matching, diseases within the user-submitted query are semantically identified in the ontology graph. In diseases relatedness detection, the relatedness between the two diseases is detected by using bidirectional-based spreading activation on the ontology graph. The classification of these diseases is provided as well.
Principles and Analysis of Biological Networks
Authors: Sehgal Manika , Singh TirathaRaj
Published: November 2019

The biological network complexity is growing enormously and in order to reveal confined properties of these intricate networks, detection of crucial network components may assist in gaining effortless perceptive on the underlying biological processes. Analyzing complex biological pathways for their disease association is still a drawn-out process and requires an integrative approach for comprehensive examination of proteins and interactions to identify candidate markers underlying major malignancies and genetic disorders. There is a need for an amalgamated approach to annotate all the sub-components and their associated interactions in a biological system. It is anticipated that analysis of biological pathways would serve as a valuable accompaniment for analyzing biomarkers in disease pathways and will also contribute scientific knowledge towards their better understanding.
A Hybrid Kernel Extreme Learning Machine and Improved Cat Swarm Optimization for Microarray Medical Data Classification
Authors: Chakravarty S. , Bisoi R. , Dash P. K.
Published: November 2019

This paper presents the pattern classification of the binary microarray gene expression based medical data using extreme learning machine (ELM) and its variants like on-line sequential ELM (OSELM) and kernel based extreme learning machine (KELM). In the KELM category two variants namely the wavelet based kernel (WKELM) extreme learning machine and radial basis kernel extreme learning machine (RKELM) along with support vector machine (SVMRBF) and support vector machine polynomial (SVMPoly) are used to classify microarray medical datasets. Further to reduce the high dimensionality of Microarray medical datasets giving rise to high number of gene expression and small sample sizes, a modified evolutionary cat swarm optimization (MCSO) technique is adopted. The efficiency of the proposed algorithm is verified using a set of performance metrics for four binary medical datasets belonging to breast cancer, prostate cancer, colon tumor, and leukemia, respectively.
Electromyography-Based Functional Electrical Stimulation (FES) in Rehabilitation
Authors: Ghosh Poulami , Mazumder Ankita , Banerjee Anwesha , Tibarewala D.N.
Published: November 2019

Loss or impairment in the ability of muscle movement or sensation is called Paralysis which is caused by disruption of communication of nerve impulses along the pathway from the brain to the muscles. One of the principal reasons causing paralysis is Spinal Cord Injury (SCI) and Neurological rehabilitation by using neuro-prostheses, based on Functional Electrical Stimulation (FES) is extensively used for its treatment. Impaired muscles are activated by applying small amplitude electrical current. Electromyography (EMG), the recording of biosignals generated by muscle activity during the application of FES can be used as the control signal for FES based rehabilitative devices. This method is predominantly used for restoring upper extremity functioning (wrist, hand, elbow, etc.), standing, walking (speed, pattern) in stroke patients. FES, collaborated with conventional methods, has the potential to be utilized as a useful tool for rehabilitation and restoration of muscle strength, metabolic responses etc. in paralyzed patients.
A Novel Delay-Based GFSK Demodulator in 65 nm CMOS for Low Power Biomedical Applications
Authors: Fu Meng , Skafidas Stan , Mareels Iven
Published: November 2019

This article describes how, in recent years, with the development of microelectronics, implantable electronic devices have been playing a significant role in modem medicine. Examples of such electronic implant devices are, for instance, retinal prosthesis and brain implants. It brings great challenges in low power radio frequency (RF) and analog designs. This article presents a low power Gaussian frequency shift keying (GFSK) demodulator designed for Medical Implant Communications Service (MICS) band Receiver. This demodulator utilizes a novel structure that a wide IF range can be handled and presents the smallest Δf/f ratio in any published GFSK demodulators. In theory the demodulation method can be applied to any RF frequency. The demodulator draws 550uA from a 1 V power supply. A maximum data rate of 400 Kbits/s can be achieved within the 300 KHz channel bandwidth defined by MICS. A simulated signal-to-noise ratio (SNR) of 15.2dB at AWGN channel is obtained to achieve 10-3 bit error rate (BER). This demodulator is fabricated on 65-nm CMOS and occupies 0.12mm2 silicon area.
An Analysis of Factors Affecting Postnatal Depression Intervention Adherence
Authors: Omisade Omobolanle , Good Alice , Fitch Tineke , Briggs Jim
Published: November 2019

Adjunct mobile support for postnatal depression could promote treatment adherence and long-term maintenance of behavioural change. The aim of this article is to establish the factors that determine adherence to postnatal depression intervention and support. Also, this article is intended to establish attitudes that women have towards postnatal depression intervention and support. Eighty-four women with a previous diagnosis of postnatal depression completed an online questionnaire on their previous use of postnatal depression intervention and factors inhibiting adherence, as well as attitudes towards the intervention. Results showed that adjunct support and combining multiple interventions would improve adherence. The provision of treatment guidance will also positively enhance treatment uptake and retention. Therefore, these factors should be considered for the development of theory-based adjunct mobile application for postnatal depression.
Modelling and Simulating Complex Systems in Biology
Authors: Ballet Pascal , Rivière Jérémy , Pothet Alain , Theron Michaël , Pichavant Karine , Abautret Frank , Fronville Alexandra , Rodin Vincent
Published: November 2019

Modelling and teaching complex biological systems is a difficult process. Multi-Agent Based Simulations (MABS) have proved to be an appropriate approach both in research and education when dealing with such systems including emergent, self-organizing phenomena. This chapter presents NetBioDyn, an original software aimed at biologists (students, teachers, researchers) to easily build and simulate complex biological mechanisms observed in multicellular and molecular systems. Thanks to its specific graphical user interface guided by the multi-agent paradigm, this software does not need any prerequisite in computer programming. It thus allows users to create in a simple way bottom-up models where unexpected behaviours can emerge from many interacting entities. This multi-platform software has been used in middle schools, high schools and universities since 2010. A qualitative survey is also presented, showing its ability to adapt to a wide and heterogeneous audience. The Java executable and the source code are available online at http://virtulab.univ-brest.fr.
PAGeneRN
Authors: Elsayad Dina , Ali A. , Shedeed Howida A. , Tolba Mohamed F.
Published: November 2019

The gene expression analysis is an important research area of Bioinformatics. The gene expression data analysis aims to understand the genes interacting phenomena, gene functionality and the genes mutations effect. The Gene regulatory network analysis is one of the gene expression data analysis tasks. Gene regulatory network aims to study the genes interactions topological organization. The regulatory network is critical for understanding the pathological phenotypes and the normal cell physiology. There are many researches that focus on gene regulatory network analysis but unfortunately some algorithms are affected by data size. Where, the algorithm runtime is proportional to the data size, therefore, some parallel algorithms are presented to enhance the algorithms runtime and efficiency. This work presents a background, mathematical models and comparisons about gene regulatory networks analysis different techniques. In addition, this work proposes Parallel Architecture for Gene Regulatory Network (PAGeneRN).
Optimal Intervention Methods for Markovian Gene Regulatory Networks
Authors: Yousefi Mohammadmahdi Rezaei
Published: November 2019

A central problem in translational medicine is to provide a framework for deriving and studying effective intervention methods to elicit desired steady-state behavior for a gene regulatory network of interest with Markovian dynamics. Heretofore, two rather different external control approaches have been taken. The first optimizes a subjectively defined cost function while modeling treatment constraints; therefore, desirable shift of the steady-state mass is a by-product. The second approach, on the other hand, focuses solely on the steady-state behavior of the network and provides the maximal shift achievable. Although both approaches are optimal with respect to their objectives, the choice of which to use depends on the treatment goals.
Healthy 3.0
Authors: Tiago Maria Teresa Borges , Tiago Flávio , Amaral Francisco Emanuel Batista , Silva Sandra
Published: November 2019

Over the past few years, healthcare practice has evolved to include new forms of information and communication technologies, and healthcare providers have begun to leverage IT solutions and the internet to reach consumers in transformative ways. There is a common thought both in business and academia that the technology adoption process is a key component of success and allows firms to achieve and sustain competitive advantages. Therefore, this research attempts to reinforce the assessment of ICT impacts on healthcare, analyzing it from two different perspectives: 1) firm performance, which is measured as a combination of induced and intangible benefits beyond the traditional financial benefits; and 2) healthcare providers' acceptance and adoption of ICT tools. To assess the first perspective, a structural equation model was applied to a large database sample covering firms from 17 European countries. The results reinforce the importance of induced and structural benefits in firms' overall performance. The second perspective was analyzed only for the Portuguese healthcare providers sample. These results can be a starting point for rethinking the healthcare models emphasizing the perspectives of Healthy 2.0 and considering that patients' technological pattern evolution will lead to Healthy 3.0 in the short term. Nevertheless, some questions remain unanswered regarding the impacts of the ICT acceptance process on overall benefits; therefore, future research will focus on this domain.
Informed Consent in Healthcare
Authors: Yu Bo , Wijesekera Duminda , Costa Paulo Cesar G.
Published: November 2019

Informed consents, either for treatment or sensitive information use/disclosure, that protect the privacy of patient/participant information subject to law that in certain circumstances may override patient wishes, are mandatory practice in healthcare. Similarly, for protecting and respecting research participants, informed consents are also prerequisite for human subjects research. Although the healthcare industry has widely adopted Electronic Medical Record (EMR) systems, consents are still obtained and stored primarily on paper or scanned electronic documents. Integrating a consent management system for different purposes into an EMR system involves various implementation challenges. A case study, informed consent for genetic services, is used to show how genetic informed consents placed new challenges on the traditional ethical standards of informed consent, and how appropriate consents can be electronically obtained and automatically enforced using a system that combines medical workflows and hierarchically, ontologically motivated rule enforcement. Finally, this chapter describes an implementation that uses the open-source software-based addition of these components to an open-source EMR system, so that existing systems do not need to be scrapped or otherwise rendered obsolete.
Perceptions of Play
Authors: Lace-Costigan Gemma
Published: November 2019

Playful and kinaesthetic learning approaches are used in numerous early years (birth to 5 years old) learning environments, however studies in HE STEM disciplines are uncommon. This study aimed to explore the use of Play-Doh in an undergraduate anatomy module as a method of enhancing engagement. 63 students attended the ‘kinaesthetic play' lecture, where students worked in teams to make a variety of epithelial cell types using Play-Doh. Before and after the activity, students were asked to ‘choose one word to describe how you feel'. Before the activity, 48.3% of responses were negative (E.g. confused, worried, childish). However, after the activity not a single negative response was recorded. 98% of students reported that they enjoyed the activity and 84% reported that the activity increased their understanding. This data suggests a utility for kinaesthetic playful practice in STEM teaching. Overcoming initial student perceptions towards alternative teaching practices is a challenge to be considered during session design.
Real Time Analysis Based on Intelligent Applications of Big Data and IoT in Smart Health Care Systems
Authors: Rath Mamata
Published: November 2019

Currently, there is an expanding interest for additional medical data from patients about their healthcare choices and related decisions, and they further need investment in their basic health issues. Big data provides patients presumptuous data to help them settle on the best choice and align with their medicinal treatment plan. One of the very advanced concepts related to the synthesis of big data sets to reveal the hidden pattern in them is big data analytics. It involves demanding techniques to mine and extract relevant data that includes the actions of piercing a database, effectively mine the data, query and inspect the data and is committed to enhance the technical execution of various task segments. The capacity to synthesize a lot of data can enable an association to manage data that can influence the business. In this way, the primary goal of big data analytics is to help business relationships to have enhanced comprehension of data, and subsequently, settle on proficient and very much educated decisions. Big data analytics empowers data diggers and researchers to examine an extensive volume of data that may not be outfit utilizing customary apparatuses. Big data analytics require advances and statistical instruments that can change a lot of organized, unstructured, and semi-organized data into more reasonable data and metadata designed for explanatory procedures. There is tremendous positive potential concerning the application of big data in human health care services and many related major applications are still in their developmental stages. The deployment of big data in health service demonstrates enhancing health care results and controlling the expenses of common people due to treatment, as proven by some developing use cases. Keeping in view such powerful processing capacity of big data analytics in various technical fields of modern civilization related to health care, the current research article presents a comprehensive study and investigation on big data analytics and its application in multiple sectors of society with significance in health care applications.
Overview of Cellular Computing-Basic Principles and Applications
Authors: Das Amit , Dasgupta Rakhi , Bagchi Angshuman
Published: November 2019

Computers, due to their raw speed and massive computing power, have been highly used by biologists to expedite life science research whereas several computational algorithms like artificial neural network, genetic algorithm and many similar ones have been inspired by the behaviors of several biological or cellular entities. However till date both these disciplines i.e. life sciences and computer sciences have mostly progressed separately while recent studies are increasingly highlighting the impact of each discipline on the other. The chapter describes several features of biological systems which could be used for further optimizations of computer programs or could be engineered to harness necessary computational capabilities in lieu of traditional silico chip systems. We also highlight underlying challenges and avenues of implementations of cellular computing.
Increasing LGBTQ+ Competencies in Preservice Teacher Training Programs
Authors: Balius Kevin B. , Ferguson Susan
Published: November 2019

As the national conversation forces LGBTQ+ rhetoric into the mainstream, some feel that the landscape is safe for those desiring to be open about their identity as well as for conversations and topics involving LGBTQ+ issues. Those who identify as LGBTQ+ and those who are familiar with or close to them might suggest a differing perspective—one that points to a deficit of safe spaces for discussing and being open about LGBTQ+ issues. While at times controversial, the English language arts classroom has been a forum for addressing issues that are difficult to discuss in other contexts, whether with literature as a backdrop for conversations or by utilizing written expression to work through concerns and questions. Since many educators seem unaware of the need for LGBTQ+ awareness, preservice teacher education is a place to begin. This chapter illustrates the need for equipping preservice teachers with the tools for introducing and discussing LGBTQ+ issues and topics through the context of the English language arts classroom.
From Me to We
Authors: Babino Alexandra , Dixon Kathryn
Published: November 2019

While the heterogeneity of public school students continues to grow, the demographics of classroom educators remain the same: Many students identify as part of traditionally marginalized groups according to their race, class, religious beliefs, gender identity, and sexual orientation, but teachers often identify as traditionally dominant groups of white, middle class, Christian, straight, and cis-gender. Thus, in order to effectively prepare elementary educators to work with diverse, marginalized students, there is a great gap that must be bridged. This chapter details how teacher preparations programs may be uniquely positioned to develop teachers' understanding and pedagogy for pluralistic and inclusive classrooms by exploring the multi-year, qualitative action research of one EC-6 teacher preparation program in the southern United States.
Sounds of Silence
Authors: Revelle Carol , Waugh Anna
Published: November 2019

This chapter juxtaposes the efforts of the authors to bring an LGBTQ+ text, Love is Love (2017), into their curriculum through a literature circle versus the hostile response of a district's administrators censoring its use in the classroom. The first section of this chapter provides a review of literature to encourage the use of diverse texts in the curriculum in support of this vulnerable population and is followed by a theoretical framework for analyzing and including LGBTQ+ texts in curriculum. The next section describes the events that occurred that led to the censorship of the literature circle and the eventual banning of the LGBTQ+ text. This section ends with a resource list to support teachers who advocate for diverse texts. The final section connects the events at the school with an analysis that demonstrates the efforts to silence the voices of LGBTQ+ students and their advocates. This case provides patterns of oppression in the hopes of naming and ending these practices and offering solidarity to others who may have these experiences.
LBGTQ+ Books Within Middle School Libraries and How Librarians Promote These LGBTQ+ Books to Students
Authors: Vallie Kristal Elaine , Szabo Susan
Published: November 2019

This mixed methods study allowed the researchers to explore the lesbian, gay, bisexual, transgender, and questioning (LGBTQ+) materials available in public middle school libraries and to interview six middle school librarians about their perceptions on “caring about and caring for” in order to provide middle school students with LGBTQ+ books. The study took place in one Texas school district. The quantitative data came from the middle school libraries' online database to determine how many LGBTQ+-themed young-adult books were found in each of the 12 school libraries. The findings revealed that the middle-school libraries offered very few LGBTQ+-themed books for students to checkout. The qualitative data came from interviewing six middle school librarians. Their stories revealed two critical themes toward LGBTQ+ books within their school library: (1) librarians' perceptions and reactions to students' needs and (2) librarians' perceptions and reactions regarding silence within the district.
Uncomfortable Territory
Authors: Distiller Natasha
Published: November 2019

This chapter reviews the historical and cultural emergence of the categories of LGBTQ+ identities and seeks to understand why knowing this background matters for the work of designing inclusive policies and welcoming school spaces: focusing on the normative system that produces and polices sexual and gender “deviance” is a crucial part of understanding what we are trying to change. The chapter will also provide an overview of the approaches to gender creative children in order to illustrate why affirming someone's gender entails engaging with the assumptions behind the concept of gender itself. It will argue that expanding the possibilities of gender identification additionally positively impacts not only queer students, but all of us. It provides readers the chance to think about how deeply their own gender runs through their assumptions and to understand what is at stake for this culture when we ask to include LGBTQ+ identities in school curricula and policies.
Incorporating Innovative Instructional Strategies to Enhance Learner Engagement in Online College Courses
Authors: Orr Lynne , Weekley Linda , Reyes Brianna
Published: November 2019

The effectiveness of innovative college teaching in online learning can be measured by learner engagement. Online learners in a master's degree program in education have expressed and shown an increase in learner engagement through the facilitation of innovative practices in addition to a synchronized weekly Skype session to apply innovative practices. These practices have proven to increase learner engagement and decrease completion time for doctoral study candidates. The two online programs will describe how the inclusion of innovation in online instructional strategies increases learner engagement. Solutions and recommendations for effective instructional strategies will also be reviewed in relation to facilitating learner engagement.
Teacher Activities in Adaptation of Innovative Study Methods at University
Authors: Gaiziuniene Lina , Janiunaite Brigita , Horbacauskiene Jolita
Published: November 2019

The emergence of various types of educational innovations affect and change not only students learning methods but also teachers' competences and activities. Innovative study methods (ISM) are characterised by novelty to their implementers. Adoption of innovations as well as innovative study methods are faster and better when they are close from cultural-, social-, and value-based perspectives (i.e., when they are adapted). The teacher should have the appropriate competences to adapt, modify educational innovations, as well as study methods according to the students while at the same time not departing from the study program aims and study subject (module) results. The chapter aims to find answers to the research questions: What are the peculiarities of teachers' activities in adapting innovative study methods? How does the adaptation of an innovative study method affect other elements of the pedagogical system course? What are the possible variations in the process of innovative study method adaptation?
Motivating Architecture Students in the Design Studio
Authors: Farag Alshimaa Aboelmakarem
Published: November 2019

This chapter aims to discuss the power of motivation in achieving a productive and fruitful learning experience in the Design Studio. The objective is to provide focus on the students' motivation determinants in the Architecture Design Studio within the opportunity to present case studies for learning innovations in a female university in the Kingdom of Saudi Arabia. The discussion focuses on the instructor-student interrelationship built as it has been adopted in several cases in the Design Studio courses at different levels at the Architecture department. The presented case studies introduce Design Studio activities and implementation to get students to be more motivated to learn and investigate innovative ideas for incorporating learning techniques. This chapter emphasizes the innovation, implementation, and the barriers and difficulties in teaching Architecture Design Studio courses to Saudi female students. The current discussion aims to foster initiatives that influence students' behavior, instructors' decision-making, and educational adopted policy.
Evaluating Barriers to and Opportunities for Higher Education in the Hispanic Community
Authors: Perelli Lisa
Published: November 2019

Although the Hispanic population in the United States is growing faster than any other ethnic group, college graduation rates, especially above the associates degree level, remain low, too low for the United States to remain academically and economically competitive in the years to come. Hispanics, on the whole, remain poorer and less educated than other ethnic groups, which could have significant economic impact on the United States, if left un-remediated, as their numbers continue to rise. Some of the questions and issues to be addressed in considering this gap in educating this population include cultural or financial barriers to attending college, bias in K-12 education and college recruitment strategies, retention and graduation issues specific to Hispanics, and high school and community college preparation of immigrant and other Hispanic students for transferring to four-year institutions.
Multicultural Advising
Authors: Robinson Chloe , Williams Tomicka N.
Published: November 2019

Since the cultural landscape of most higher education institutions is changing, it is paramount that colleges and universities make a concerted effort to connect with students from various backgrounds. The academic advising department could be the catalyst for change for many institutions of higher learning when seeking to support a diverse student body. Despite an increase in enrollment of students from various backgrounds on many college campuses, various challenges remain when attempting to advise and mentor diverse student populations. This chapter will examine some of the demographical changes taking place on college campuses across the U.S., the importance of multicultural advising and core components of this approach. Finally, the ways in which multicultural advising can be implemented within higher education will be examined.