bluuebunny/crossref_metadata_2025 huggingface dataset:
Mindfulness-based online intervention on mental health and quality of life among COVID-19 patients in China: an intervention design
Authors: Si Ming-Yu , Xiao Wei-Jun , Pan Chen , Wang Hao , Huang Yi-Man , Lian Jun , Mak Winnie W. S. , Leng Zhi-Wei , Su Xiao-You , Tang Qiu-Ping , Jiang Yu , Feng Lu-Zhao , Yang Wei-Zhong , Wang Chen
Published: May 2021

Background

COVID-19 can lead to increased psychological symptoms such as post-traumatic stress disorder (PTSD), depression, and anxiety among patients with COVID-19. Based on the previous mindfulness-based interventions proved to be effective, this protocol reports a design of a randomized controlled trial aiming to explore the efficacy and possible mechanism of a mindful living with challenge (MLWC) intervention developed for COVID-19 survivors in alleviating their psychological problems caused by both the disease and the pandemic.

Methods

In April 2021, more than 1600 eligible participants from Hubei Province of China will be assigned 1:1 to an online MLWC intervention group or a waitlist control group. All participants will be asked to complete online questionnaires at baseline, post-program, and 3-month follow-up. The differences of mental health status (e.g. PTSD) and physical symptoms including fatigue and sleeplessness between the COVID-19 survivors who receiving the online MLWC intervention and the control group will be assessed. In addition, the possible mediators and moderators of the link between the MLWC intervention and target outcomes will be evaluated by related verified scales, such as the Five Facets Mindfulness Questionnaire. Data will be analyzed based on an intention-to-treat approach, and SPSS software will be used to perform statistical analysis.

Discussion

The efficacy and potential mechanism of MLWC intervention in improving the quality of life and psychological status of COVID-19 survivors in China are expected to be reported. Findings from this study will shed light on a novel and feasible model in improving the psychological well-being of people during such public health emergencies.

Trial registration Chinese Clinical Trial Registry (ChiCTR), ChiCTR2000037524; Registered on August 29, 2020, http://www.chictr.org.cn/showproj.aspx?proj=60034.
Functions of RNA N6-methyladenosine modification in acute myeloid leukemia
Authors: Zheng Xue , Gong Yuping
Published: May 2021

Acute myeloid leukemia (AML) is a hematologic malignancy with an unfavorable prognosis. A better understanding of AML pathogenesis and chemotherapy resistance at the molecular level is essential for the development of new therapeutic strategies. Apart from DNA methylation and histone modification, RNA epigenetic modification, another layer of epigenetic modification, also plays a critical role in gene expression regulation. Among the more than 150 kinds of RNA epigenetic modifications, N6-methyladenosine (m6A) is the most prevalent internal mRNA modification in eukaryotes and is involved in various biological processes, such as circadian rhythms, adipogenesis, T cell homeostasis, spermatogenesis, and the heat shock response. As a reversible and dynamic modification, m6A is deposited on specific target RNA molecules by methyltransferases and is removed by demethylases. Moreover, m6A binding proteins recognize m6A modifications, influencing RNA splicing, stability, translation, nuclear export, and localization at the posttranscriptional level. Emerging evidence suggests that dysregulation of m6A modification is involved in tumorigenesis, including that of AML. In this review, we summarize the most recent advances regarding the biological functions and molecular mechanisms of m6A RNA methylation in normal hematopoiesis, leukemia cell proliferation, apoptosis, differentiation, therapeutic resistance, and leukemia stem cell/leukemia initiating cell (LSC/LIC) self-renewal. In addition, we discuss how m6A regulators are closely correlated with the clinical features of AML patients and may serve as new biomarkers and therapeutic targets for AML.
Genetic inactivation of SARM1 axon degeneration pathway improves outcome trajectory after experimental traumatic brain injury based on pathological, radiological, and functional measures
Authors: Bradshaw Donald V. , Knutsen Andrew K. , Korotcov Alexandru , Sullivan Genevieve M. , Radomski Kryslaine L. , Dardzinski Bernard J. , Zi Xiaomei , McDaniel Dennis P. , Armstrong Regina C.
Published: May 2021

Traumatic brain injury (TBI) causes chronic symptoms and increased risk of neurodegeneration. Axons in white matter tracts, such as the corpus callosum (CC), are critical components of neural circuits and particularly vulnerable to TBI. Treatments are needed to protect axons from traumatic injury and mitigate post-traumatic neurodegeneration. SARM1 protein is a central driver of axon degeneration through a conserved molecular pathway. Sarm1−/− mice with knockout (KO) of the Sarm1 gene enable genetic proof-of-concept testing of the SARM1 pathway as a therapeutic target. We evaluated Sarm1 deletion effects after TBI using a concussive model that causes traumatic axonal injury and progresses to CC atrophy at 10 weeks, indicating post-traumatic neurodegeneration. Sarm1 wild-type (WT) mice developed significant CC atrophy that was reduced in Sarm1 KO mice. Ultrastructural classification of pathology of individual axons, using electron microscopy, demonstrated that Sarm1 KO preserved more intact axons and reduced damaged or demyelinated axons. Longitudinal MRI studies in live mice identified significantly reduced CC volume after TBI in Sarm1 WT mice that was attenuated in Sarm1 KO mice. MR diffusion tensor imaging detected reduced fractional anisotropy in both genotypes while axial diffusivity remained higher in Sarm1 KO mice. Immunohistochemistry revealed significant attenuation of CC atrophy, myelin loss, and neuroinflammation in Sarm1 KO mice after TBI. Functionally, Sarm1 KO mice exhibited beneficial effects in motor learning and sleep behavior. Based on these findings, Sarm1 inactivation can protect axons and white matter tracts to improve translational outcomes associated with CC atrophy and post-traumatic neurodegeneration.
Body connection mediates the relationship between traumatic childhood experiences and impaired emotion regulation in borderline personality disorder
Authors: Schmitz Marius , Bertsch Katja , Löffler Annette , Steinmann Sylvia , Herpertz Sabine C. , Bekrater-Bodmann Robin
Published: May 2021

Background

Previous studies revealed an association between traumatic childhood experiences and emotional dysregulation in patients with borderline personality disorder (BPD). However, possible mediating pathways are still not fully understood. The aim of the present study was to investigate the potential mediating role of body connection, describing the awareness of the relationship of bodily and mental states, for the association between a history of traumatic childhood experiences and BPD core symptomatology.

Methods

One-hundred-twelve adult female individuals with BPD and 96 healthy female controls (HC) were included. Impaired emotion regulation, traumatic childhood experiences, and BPD symptomatology were assessed with self-report questionnaires. The Scale of Body Connection was used to assess two dimensions of body connection, that is body awareness, describing attendance to bodily information in daily life and noticing bodily responses to emotions and/or environment and body dissociation, describing a sense of separation from one’s own body, due to avoidance or emotional disconnection. Mann-Whitney U tests were employed to test for group differences (BPD vs. HC) on the two SBC subscales and associations with clinical symptoms were analyzed with Spearman correlations. We performed mediation analyses in the BPD group to test the assumption that body connection could act as a mediator between a history of traumatic childhood experiences and emotion dysregulation.

Results

Individuals with BPD reported significantly lower levels of body awareness and significantly higher levels of body dissociation compared to HC. Body dissociation, traumatic childhood experiences, and emotion dysregulation were significantly positively associated. Further analyses revealed that body dissociation, but not body awareness, significantly and fully mediated the positive relationship between traumatic childhood experiences and impaired emotion regulation in the BPD sample. This mediation survived when trait dissociation, i.e., general dissociative experiences not necessarily related to the body, was statistically controlled for.

Conclusion

Certain dimensions of body connection seem to be disturbed in BPD patients, with body dissociation being an important feature linking a history of traumatic childhood experiences to current deficits in emotion regulation.
Plant–rodent interactions after a heavy snowfall decrease plant regeneration and soil carbon emission in an old-growth forest
Authors: Zhou Qingqiu , Li Debao , Xia Shangwen , Chen Zhe , Wang Bo , Wu Jianping
Published: May 2021

Background

Climate extremes are likely to become more common in the future and are expected to change ecosystem processes and functions. As important consumers of seeds in forests, rodents are likely to affect forest regeneration following an extreme weather event. In April 2015, we began a field experiment after an extreme snowfall event in January 2015 in a primary forest that was > 300 years old. The heavy snow broke many tree limbs, which presumably reduced the numbers of seeds produced. Two treatments (rodent exclusion and rodent access) were established in the forest, in which rodent exclusion were achieved by placing stainlessness nets around the plot borders. Plant abundance, plant species richness, soil properties, soil microbial community composition, basal and substrate-induced respiration were determined in December 2017.

Results

Plant abundance and species richness significantly increased, but soil microbial biomass decreased with rodent exclusion. Urease activity and soil basal respiration also significantly decreased with rodent exclusion. Most other soil properties, however, were unaffected by rodent exclusion. The relative effects of multiple predictors of basal respiration were mainly explained by the composition of the soil microbial community.

Conclusions

After a heavy snowfall in an old-growth forest, exclusion of rodents increased plant regeneration and reduced microbial biomass and soil basal respiration. The main factor associated with the reduction in soil basal respiration was the change in the composition of the soil microbial community. These findings suggest that after a heavy snowfall, rodents may interfere with forest regeneration by directly reducing plant diversity and abundance but may enhance carbon retention by indirectly altering the soil microbial community.
A Markov regenerative process with recurrence time and its application
Authors: Pasricha Puneet , Selvamuthu Dharmaraja
Published: May 2021

This study proposes a non-homogeneous continuous-time Markov regenerative process with recurrence times, in particular, forward and backward recurrence processes. We obtain the transient solution of the process in the form of a generalized Markov renewal equation. A distinguishing feature is that Markov and semi-Markov processes result as special cases of the proposed model. To model the credit rating dynamics to demonstrate its applicability, we apply the proposed stochastic process to Standard and Poor’s rating agency’s data. Further, statistical tests confirm that the proposed model captures the rating dynamics better than the existing models, and the inclusion of recurrence times significantly impacts the transition probabilities.
EU migrant retention and the temporalities of migrant staying: a new conceptual framework
Authors: Hof Helena , Pemberton Simon , Pietka-Nykaza Emilia
Published: May 2021

Challenges of weak economic growth, population decline, and labour shortages led many countries across the world to introduce immigration policy changes in order to attract foreign migrants. This paper focuses on Japan (Tokyo) and the UK (Birmingham, Edinburgh and Glasgow) given common concerns over long term demographic trends and the burgeoning lack of labour supply in particular sectors of the economy through use of foreign labour. The paper shifts the focus from efforts focused on attracting and selecting foreign labour to the retention of such individuals. Drawing on research with EU migrants in Japan and the UK, the paper highlights how staying may occur after a period of mobility, rather than only being of relevance to those who never left their home region. The paper develops a new conceptual framework, which helps to identify different dimensions that shape migrant staying as a temporal process. It is highlighted how staying is shaped incrementally and facilitated or undermined over time in relation to the reciprocal importance of diverse assets, anchors and the changing biographies of migrants and the places in which they live – as well as the relational aspects of migrants’ ‘linked lives’.
Morphological alternation and influence of aqueous flare in idiopathic epiretinal membrane
Authors: Ikegami Yasuko , Numaga Jiro , Ue Saori , Sano Tomohiro
Published: May 2021

Background

Idiopathic epiretinal membrane (iERM) is a common retinal disease in the elderly population. The exact pathogenesis of iERM is unknown. The present study aimed to evaluate the relationship between aqueous flare and morphology of iERM using swept-source optical coherence tomography (OCT).

Methods

A consecutive series of 36 eyes of 33 patients with iERM and 109 control eyes of 109 patients were retrospectively examined. Aqueous flare measurements and OCT images were obtained on the same day. The average total retinal, inner retinal, outer retinal, and choroidal thicknesses were calculated using the thickness map mode with an Early Treatment Diabetic Retinopathy Study nine-zone grid that was divided into three zones. The maximum depth of the retinal folds in iERMs was manually measured. The correlation among flare value, maximum depth of folds, and retinal and choroidal thicknesses was evaluated. The morphological changes between the control eyes and the eyes with iERM in different stages were examined.

Results

The result demonstrated a significant positive correlation between the aqueous flare value and total and inner retinal thicknesses in the early stage of iERM. There was a significant positive correlation between the maximum depth of folds and total and inner retinal thicknesses in the early stage of iERM, and the maximum depth of folds significantly increased in the advanced stage. The total and inner retinal thicknesses and proportion of inner retinal thickness significantly increased as the stage of iERM progressed.

Conclusions

The aqueous flare value was associated with retinal thickness in the early stage of iERM, which supports the idea that inflammation or breakdown of blood–ocular barrier is involved in the process of iERM formation. The maximum retinal folds increased as the stage of iERM progressed and retinal thickness increased, which indicates that the tangential force increases as the iERM stage progresses.
Frictions of implementing EU humanitarian aid in Greece (2016–2019)—the Emergency Support Instrument and its practical ramifications
Authors: Dittmer Cordula , Lorenz Daniel F.
Published: May 2021

With the closure of the border with then-Macedonia in early 2016, it was foreseeable that Greece would become the “last station” for a large number of refugees. Flanked by the agreement between Turkey and the European Union of March 2016, Greece underwent a profound transformation from a transit country to a recipient country. Through a new regulation, the Emergency Support Instrument, initially activated by the European Commission 2016–2019, international humanitarian aid operations were supported for the first time in the EU. The article analyzes the resulting frictions on the basis of empirical field research and a broad literature review. While frictions similar to those in other non-European humanitarian operations exist, specific peculiarities due to the operation taking place in an austerity-ridden member state of the EU must also be noted.
Endemism-based butterfly conservation: insights from a study in Southern Western Ghats, India
Authors: Anto M. , Binoy C. F. , Anto Ignatious
Published: May 2021

Background

The Western Ghats, a biodiversity hotspot in India harbours a high percentage of endemic species due to its unique and diverse habitats. These species which cannot survive elsewhere due to their specialised habitat requirements are at high risk from climatic and anthropogenic disturbances. The butterfly fauna of the region although well documented has not been investigated intensively at local scales. In this study, we present information on species presence within 10 km × 10 km grid cells (n= 30; area=3000 km2) of 94 butterfly species in the Western Ghats region. The data on the species distribution within these grids which included three wildlife sanctuaries and four forest divisions was mapped. Indicator analysis was performed in R using multipatt function in indispecies package to determine species associated with sites/site combinations. The corrected weighted endemism indices of the study grids were estimated.

Results

The data collected over a 4-year period comprised of 393 records of 60 endemic species belonging to five families observed along 102 transects. Troides minos was the most widespread species occuring in 19 grids. Seventeen species indicative of sites and site combinations were obtained, of which Cirrochroa thais, Papilio paris tamilana, Papilio helenus daksha, Parthenos sylvia virens and Mycalesis patnia were significant. The highest corrected weighted endemism index was observed in grid 25 (14.44) followed by grids 24 (12.06) and 19 (11.86). Areas harbouring unique and range restricted species were Parambikulam WLS/TR: Kuthirakolpathy, Pupara, Kalyanathi, Top slip and Muthalakuzhy; Peechi-Vazhani WLS: Ayyapankadu; Thrissur FD: Chakkapara and Vellakarithadam; Nenmara FD: Karikutty, Pothumala and Nelliampathy estate; Vazhachal FD: Poringalkuthu dam, Meenchal and Vazhachal.

Conclusions

The study area which covers 2.14% of the Western Ghats hotspot harbours almost 63.82% of the region’s endemic butterfly species making this particular region crucial for butterfly conservation and management. Studying the phylogenetic endemism of the butterflies, identification of microrefugia and testing the mountain geobiodiversity hypothesis with respect to butterflies are the suggested approaches to be adopted for fine-tuning research and conservation of butterflies in this fragile hotspot.
Botulinum toxin type A for painful diabetic neuropathy: an open-label study
Authors: Helmy Shahinaz , Emara Tamer , Menem Amr Abdel
Published: May 2021

Background

A large proportion of painful diabetic neuropathy cases either do not respond or are intolerant to the currently available oral and physical therapies. There is encouraging evidence from a small number of studies that those patients can improve using botulinum toxin injection. The aim of the study was to evaluate the effect of intradermal injection of botulinum toxin type A on painful diabetic neuropathy. Eight adult patients with diabetic peripheral neuropathy (DPN), confirmed by nerve conduction studies, were refractory to a minimum of two neuropathic pain treatments for 6 months or more were recruited. All cases received intradermal injection of 48 units of botulinum toxins—type A in each foot in 6×4 distribution. Follow-up was done after 8 weeks using the Neuropathic Pain Scale (NPS), Pittsburgh Sleep Quality Index (PSQI), and Overall Disability Sum Scale (ODSS).

Results

After 8 weeks, there was a significant change in NPS from 55.8 (7.8) to 38.5 (8.1) (p value 0.007), also there was significant improvement in ODDS from 4 (IQR, 2.25-4.75) to 2.5 (IQR, 0.5-3) (p value 0.01). However, there was no significant change in PSQI.

Conclusion

Botulinum toxin type A injection is a promising treatment option in Egyptian DPN adults in this study.
In vitro study of protective effect of Pterocarpus erinaceus Poir. stem bark and Amaranthus spinosus L. root extracts on cataractogenesis and glomerulopathy
Authors: Atchou Kokou , Lawson-Evi Povi , Eklu-Gadegbeku Kwashie
Published: May 2021

Background

Cataracts and glomerulopathy are disabling complications of diabetes mellitus. The use of medicinal plants in the treatment of diabetes helps prevent or delay these complications. Pterocarpus erinaceus and Amaranthus spinosus are part of these medicinal plants used in traditional medicine to treat diabetes and its complications. The aim of this study was to evaluate in vitro the protective effect of the dried hydroethanolic extracts of the two plants against cataractogenesis and glomerulopathy induced by high glucose. Lenses and kidney fragments from Sprague–Dawley rats were cultured in artificial aqueous humor and in glomerular solution under high glucose, respectively. The extracts of the two plants at doses of 250 and 500 mg/kg bw were added to the culture medium and incubated for 72 h for the lenses and 96 h for the kidney fragments. Morphological and biochemical parameters were evaluated during the cultures.

Results

The lenses treated with extracts of both plants remained shiny and transparent in contrast to the opacity observed in toxic controls. The treatment by extract caused a significant (p < 0.001) decrease in malondialdehyde and a significant increase (p < 0.001) in glutathione and catalase levels in lenses and kidney fragments. The extracts also caused a significant increase (p < 0.0001) in glucose absorption in glomeruli and a decrease in tubular glucose reabsorption in kidney fragments. This led to a decrease in glucose in the incubation medium.

Conclusion

These findings showed that the dried hydroethanolic extract of P. erinaceus and A. spinosus can be used to reduce hyperglycemia effects by inhibiting oxidative stress pathways and then preventing or delaying the onset of cataracts and kidney failure in diabetes.
Measuring psychological pain: psychometric analysis of the Orbach and Mikulincer Mental Pain Scale
Authors: Casanova Madeline P. , Nelson Megan C. , Pickering Michael A. , Appleby Karen M. , Grindley Emma J. , Larkins Lindsay W. , Baker Russell T.
Published: May 2021

Background

Suicide is a public health concern, with an estimated 1 million individuals dying each year worldwide. Individual psychological pain is believed to be a contributing motivating factor. Therefore, establishing a psychometrically sound tool to adequately measure psychological pain is important. The Orbach and Mikulincer Mental Pain Scale (OMMP) has been proposed; however, previous psychometric analysis on the OMMP has not yielded a consistent scale structure, and the internal consistency of the subscales has not met recommended values. Therefore, the primary purpose of this study was to assess the psychometric properties of the OMMP in a diverse sample.

Methods

A confirmatory factor analysis (CFA) on the 9-factor, 44-item OMMP was conducted on the full sample (n= 1151). Because model fit indices were not met, an exploratory factor analysis (EFA) was conducted on a random subset of the data (n= 576) to identify a more parsimonious structure. The EFA structure was then tested in a covariance model in the remaining subset of participants (n= 575). Multigroup invariance testing was subsequently performed to examine psychometric properties of the refined scale.

Results

The CFA of the original 9-factor, 44-item OMMP did not meet recommended model fit recommendations. The EFA analysis results revealed a 3-factor, 9-item scale (i.e., OMMP-9). The covariance model of the OMMP-9 indicated further refinement was necessary. Multigroup invariance testing conducted on the final 3-factor, 8-item scale (i.e., OMMP-8) across mental health diagnoses, sex, injury status, age, activity level, and athlete classification met all criteria for invariance.

Conclusions

The 9-factor, 44-item OMMP does not meet recommended measurement criteria and should not be recommended for use in research and clinical practice in its current form. The refined OMMP-8 may be a more viable option to use; however, more research should be completed prior to adoption.
A guide to reducing adverse outcomes in rabbit models of sciatic nerve injury
Authors: Orozco Elisabeth , Masuda Koichi , Shah Sameer B.
Published: May 2021

Background

Peripheral nerve damage can have debilitating consequences. Rabbit sciatic nerve transection models allow the effective evaluation of surgical repair strategies for large nerve gaps. Despite advantages in size, ease of handling, and functional utility, rabbits can suffer from a number of side effects that affect animal welfare and the quality of scientific inquiry. Such side-effects, which include pressure ulcers and traumatic damage to the foot, are primarily a consequence of insensitivity of the distal hindlimb following sciatic nerve injury. In this study, we present a number of methodologies for identifying, treating, and preventing unintended adverse effects in rabbit sciatic nerve injury models.

Results

First, we categorize pressure ulcers according to their severity and describe the deployment of a padded bandaging technique to enable ulcer healing. We also introduce a proactive bandaging approach to reduce the likelihood of pressure ulcer formation. Second, we define phenotypes that distinguish between foot injuries resulting from self-mutilation (autotomy) from those caused by incidental traumatic injury secondary to sensori-motor damage. Finally, we detail an effective strategy to reduce the usage of Elizabethan collars; through a gradual weaning protocol, their usefulness in preventing autotomy is retained, while their propensity to impede rabbit grooming and cause abrasion-injury to the neck region is minimized.

Conclusions

We suggest that application of these methods offer a practical and systematic approach to avoid adverse side effects associated with rabbit sciatic nerve damage, enabling improved animal welfare and scientific outcomes in a powerful nerve injury model.
The reasons women choose and stay in a geology major: a qualitative multi-case analysis
Authors: Gray Ron E. , Riche Alexis T. , Shinnick-Gordon Isabel J. , Sample James C.
Published: May 2021

Despite earning half of all science and engineering undergraduate degrees between 2007 and 2016 in the USA, women were awarded only 39% of earth science degrees in the same time period. In order to better understand why women are both choosing and staying in geology programs, we conducted a multi-case study of nine current female undergraduate geology majors at a large public university in the USA within a department that is at gender parity among its undergraduate majors. The main data source was audio-recorded critical incident interviews of each participant. Data from the interviews were analyzed through an iterative coding process using codes adapted from previous studies that focused on factors both internal and external to the department. The students said that personal interests, influence by others outside of the department, and introductory classes attracted them to the geology program, but once declared, departmental factors such as relationship with faculty caused them to stay. We also found an emphasis on female role models, especially those teaching introductory courses. We believe this study offers important insights into the ways in which factors leading to recruitment and retention play out in the lived experiences of female geology majors.
Estimation of fractional cycle bias for GPS/BDS-2/Galileo based on international GNSS monitoring and assessment system observations using the uncombined PPP model
Authors: Wang Jin , Zhang Qin , Huang Guanwen
Published: May 2021

The Fractional Cycle Bias (FCB) product is crucial for the Ambiguity Resolution (AR) in Precise Point Positioning (PPP). Different from the traditional method using the ionospheric-free ambiguity which is formed by the Wide Lane (WL) and Narrow Lane (NL) combinations, the uncombined PPP model is flexible and effective to generate the FCB products. This study presents the FCB estimation method based on the multi-Global Navigation Satellite System (GNSS) precise satellite orbit and clock corrections from the international GNSS Monitoring and Assessment System (iGMAS) observations using the uncombined PPP model. The dual-frequency raw ambiguities are combined by the integer coefficients (4,− 3) and (1,− 1) to directly estimate the FCBs. The details of FCB estimation are described with the Global Positioning System (GPS), BeiDou-2 Navigation Satellite System (BDS-2) and Galileo Navigation Satellite System (Galileo). For the estimated FCBs, the Root Mean Squares (RMSs) of the posterior residuals are smaller than 0.1 cycles, which indicates a high consistency for the float ambiguities. The stability of the WL FCBs series is better than 0.02 cycles for the three GNSS systems, while the STandard Deviation (STD) of the NL FCBs for BDS-2 is larger than 0.139 cycles. The combined FCBs have better stability than the raw series. With the multi-GNSS FCB products, the PPP AR for GPS/BDS-2/Galileo is demonstrated using the raw observations. For hourly static positioning results, the performance of the PPP AR with the three-system observations is improved by 42.6%, but only 13.1% for kinematic positioning results. The results indicate that precise and reliable positioning can be achieved with the PPP AR of GPS/BDS-2/Galileo, supported by multi-GNSS satellite orbit, clock, and FCB products based on iGMAS.
Role of PET/CT in post-therapeutic assessment of bronchogenic carcinoma
Authors: Shaheen Amira Ayman , Mohammed Ahmed Mostafa , Elshimy Ahmed , Shalaby Mennatallah Hatem
Published: May 2021

Background

Lung cancer is the most common among all kinds of cancers. It still constitutes the leading cause of cancer-related deaths worldwide, even with major advancements in prevention and treatments available. More than 85% of the cases are of non-small cell lung cancer (NSCLC), while less than 15% are of small cell lung cancers (SCLCs).

Patients and methods

This is a prospective study of 20 patients confirmed histopathologically to have bronchogenic carcinoma, who came for assessment of therapeutic response. All patients underwent positron emission tomography/computed tomography (PET/CT) before and after therapy. Semiquantitative assessment was used to determine maximum standardized uptake value (SUVmax). Treatment response evaluation was assessed according to the Response Evaluation Criteria in Solid Tumors (RECIST) criteria.

Results

Comparison of the pre- and post-treatment SUVmax in the responder and non-responder groups revealed that the post-treatment SUV was significantly lower than the baseline SUV in the responder group (P = 0.008). The responder post-treatment SUV and ∆ SUV were significantly lower than the non-responder values (P = 0.014 and 0.0004 respectively). The optimum threshold values of post-treatment SUV and ∆ SUV threshold defined by the receiver operating characteristic (ROC) curve analysis were ≤ 8 and ≤ −48.3 respectively. The sensitivity, specificity, PPV, NPV, and AUC of post-treatment SUV for predicting tumor response were 100%, 66.67%, 66.7%, 100%, and 0.833 respectively. The sensitivity, specificity, PPV, NPV, and AUC of ∆ SUV for predicting tumor response were 100%, 91.67%, 88.9%, 100%, and 0.979% respectively.

Conclusion

PET/CT proved itself as useful, efficient, and reliable tool in follow-up of lung cancer patients as it gives an early and accurate metabolic response assessment before any CT changes, leading to early modification of therapy or confirmation of its efficiency.
Multi-modality imaging of referred civilian combat-related injuries: a multi-center study in Egypt
Authors: Grace Marie Nader , Ibrahim Iman Mohamed Hamdy , Tadros Sally Fouad
Published: May 2021

Background

Several Arab countries as well as many parts of the world are currently involved in armed conflicts. Characterization and documentation of combat-related injury patterns and their impact on healthcare are a difficult challenge. However, it is crucial in planning and developing of strategies capable of addressing the demands of ill-equipped medical facilities. The aim of this study was to record the different patterns of combat-related injuries sustained by civilians transferred to Egyptian tertiary hospitals for further investigation and definite treatment after primary stabilization by an emergency trauma team in their countries.

Results

Metallic foreign bodies were detected in different body locations in 49.1% of patients, while bullets were identified in 12.3%. Injuries involving the musculoskeletal system of the extremities were the most frequent (77.2%), followed in descending order by maxillofacial injuries (41%), thoracic injuries (32.1%), cranial injuries (31%), abdominal injuries (21.1%), spinal injuries (8.8%), and vascular injuries (4.7%). Among the extremities injuries, bone fractures were the most common (68.5%).

Conclusion

Radiological assessment aids in the evaluation of patients coming from conflict zones pre- and postoperatively, to recognize the precise sites and types of their injuries, the number and location of metallic shrapnel or bullets, and detection of possible associated complications, which aid in accurate demonstration of the extent and patterns of combat-related injuries and guide the management plan.
Evaluation of Oncology Hospital at Home: Unplanned Health Care Utilization and Costs in the Huntsman at Home Real-World Trial
Authors: Mooney Kathi , Titchener Karen , Haaland Benjamin , Coombs Lorinda A. , O'Neil Brock , Nelson Richard , McPherson Jordan P. , Kirchhoff Anne C. , Beck Anna C. , Ward John H.
Published: May 2021

PURPOSE

Patients with cancer experience high rates of morbidity and unplanned health care utilization and may benefit from new models of care. We evaluated an adult oncology hospital at home program's rate of unplanned hospitalizations and health care costs and secondarily, emergency department (ED) use, length of hospital stays, and intensive care unit (ICU) admissions during the 30 days after enrollment.

METHODS

We conducted a prospective, nonrandomized, real-world cohort comparison of 367 hospitalized patients with cancer—169 patients consecutively admitted after hospital discharge to Huntsman at Home (HH), a hospital-at-home program, compared with 198 usual care patients concurrently identified at hospital discharge. All patients met clinical criteria for HH admission, but those in usual care lived outside the HH service area. Primary outcomes were the number of unplanned hospitalizations and costs during the 30 days after enrollment. Secondary outcomes included length of hospital stays, ICU admissions, and ED visits during the 30 days after enrollment.

RESULTS

Groups were comparable except that more women received HH care. In propensity-weighted analyses, the odds of unplanned hospitalizations was reduced in the HH group by 55% (odds ratio, 0.45, 95% CI, 0.29 to 0.70; P < .001) and health care costs were 47% lower (mean cost ratio, 0.53; 95% CI, 0.39 to 0.72; P < .001) over the 30-day period. Secondary outcomes also favored HH. Total hospital stay days were reduced by 1.1 days ( P = .004) and ED visits were reduced by 45% (odds ratio, 0.55; 95% CI, 0.33 to 0.92; P = .022). There was no evidence of a difference in ICU admissions ( P = .972).

CONCLUSION

This oncology hospital at home program shows initial promise as a model for oncology care that may lower unplanned health care utilization and health care costs.
Energy and wave-action flows underlying Rayleigh-Jeans thermalization of optical waves propagating in a multimode fiber
(a)
Authors: Baudin K. , Fusaro A. , Garnier J. , Berti N. , Krupa K. , Carusotto I. , Rica S. , Millot G. , Picozzi A.
Published: May 2021

The wave turbulence theory predicts that a conservative system of nonlinear waves can exhibit a process of condensation, which originates in the singularity of the Rayleigh-Jeans equilibrium distribution of classical waves. Considering light propagation in a multimode fiber, we show that light condensation is driven by an energy flow toward the higher-order modes, and a bi-directional redistribution of the wave-action (or power) to the fundamental mode and to higher-order modes. The analysis of the near-field intensity distribution provides experimental evidence of this mechanism. The kinetic equation also shows that the wave-action and energy flows can be inverted through a thermalization toward a negative temperature equilibrium state, in which the high-order modes are more populated than low-order modes. In addition, a Bogoliubov stability analysis reveals that the condensate state is stable.
Randomized Controlled Trial of Neurokinin 3 Receptor Antagonist Fezolinetant for Treatment of Polycystic Ovary Syndrome
Authors: Fraser Graeme L , Obermayer-Pietsch Barbara , Laven Joop , Griesinger Georg , Pintiaux Axelle , Timmerman Dirk , Fauser Bart C J M , Lademacher Christopher , Combalbert Jean , Hoveyda Hamid R , Ramael Steven
Published: May 2021

Context

Polycystic ovary syndrome (PCOS), a highly prevalent endocrine disorder characterized by hyperandrogenism, is the leading cause of anovulatory infertility.

Objective

This proof-of-concept study evaluated clinical efficacy and safety of the neurokinin 3 (NK3) receptor antagonist fezolinetant in PCOS.

Methods

This was a phase 2a, randomized, double-blind, placebo-controlled, multicenter study (EudraCT 2014-004409-34). The study was conducted at 5 European clinical centers. Women with PCOS participated in the study. Interventions included fezolinetant 60 or 180 mg/day or placebo for 12 weeks. The primary efficacy end point was change in total testosterone. Gonadotropins, ovarian hormones, safety and tolerability were also assessed.

Results

Seventy-three women were randomly assigned, and 64 participants completed the study. Adjusted mean (SE) changes in total testosterone from baseline to week 12 for fezolinetant 180 and 60 mg/day were −0.80 (0.13) and −0.39 (0.12) nmol/L vs −0.05 (0.10) nmol/L with placebo (P < .001 and P < .05, respectively). Adjusted mean (SE) changes from baseline in luteinizing hormone (LH) for fezolinetant 180 and 60 mg/d were −10.17 (1.28) and −8.21 (1.18) vs −3.16 (1.04) IU/L with placebo (P < .001 and P = .002); corresponding changes in follicle-stimulating hormone (FSH) were −1.46 (0.32) and −0.92 (0.30) vs −0.57 (0.26) IU/L (P = .03 and P = .38), underpinning a dose-dependent decrease in the LH-to-FSH ratio vs placebo (P < .001). Circulating levels of progesterone and estradiol did not change significantly vs placebo (P > .10). Fezolinetant was well tolerated.

Conclusion

Fezolinetant had a sustained effect to suppress hyperandrogenism and reduce the LH-to-FSH ratio in women with PCOS.
Maintenance DNA methylation in pre-meiotic germ cells regulates meiotic prophase by facilitating homologous chromosome pairing
Authors: Takada Yuki , Yaman-Deveci Ruken , Shirakawa Takayuki , Sharif Jafar , Tomizawa Shin-ichi , Miura Fumihito , Ito Takashi , Ono Michio , Nakajima Kuniko , Koseki Yoko , Shiotani Fuyuko , Ishiguro Kei-ichiro , Ohbo Kazuyuki , Koseki Haruhiko
Published: May 2021

Heterochromatin-related epigenetic mechanisms, such as DNA methylation, facilitate pairing of homologous chromosomes during the meiotic prophase of mammalian spermatogenesis. In pro-spermatogonia, de novo DNA methylation plays a key role in completing meiotic prophase and initiating meiotic division. However, the role of maintenance DNA methylation in the regulation of meiosis, especially in the adult, is not well understood. Here, we reveal that NP95 (also known as UHRF1) and DNMT1 – two essential proteins for maintenance DNA methylation – are co-expressed in spermatogonia and are necessary for meiosis in male germ cells. We find that Np95- or Dnmt1-deficient spermatocytes exhibit spermatogenic defects characterized by synaptic failure during meiotic prophase. In addition, assembly of pericentric heterochromatin clusters in early meiotic prophase, a phenomenon that is required for subsequent pairing of homologous chromosomes, is disrupted in both mutants. Based on these observations, we propose that DNA methylation, established in pre-meiotic spermatogonia, regulates synapsis of homologous chromosomes and, in turn, quality control of male germ cells. Maintenance DNA methylation, therefore, plays a role in ensuring faithful transmission of both genetic and epigenetic information to offspring.
SESAME – a synchrotron light source in the Middle East: an international research infrastructure in the making
Authors: Rungius Charlotte , Flink Tim , Riedel Sebastian
Published: May 2021

SESAME (Synchrotron-light for Experimental Science and Applications in the Middle East) is an international research centre located in Jordan. The centre was established in the late 1990s with the intention to foster scientific cooperation in a region of the world that has been torn by persistent conflicts. The project is built on the idea that science can help to overcome barriers and cultural differences within the common ground of science and research. SESAME’s core ambition is to operate an international state-of-the-art synchrotron users’ facility in the north of Amman that is accessible to scientists from all of its member countries: Cyprus, Egypt, Iran, Israel, Pakistan, Palestine, Turkey and Jordan. Accordingly, SESAME has been often praised as a paramount example of science diplomacy. Our intention for this report was to investigate a concrete international research infrastructure with a specific science diplomacy interest. What were the enabling conditions for such a project to come into being and what keeps SESAME running? What were the challenges and obstacles? How does the composition of member states play into that? How is SESAME related to (and embedded in) the global synchrotron community, academia, researchers and political actors in the region and the world? Did the science diplomacy ambition behind the project turn out to be successful and how does it affect SESAME's future?
Nine Seasons of a Bronchiolitis Observation Unit and Home Oxygen Therapy Protocol
Authors: Ohlsen Timothy J D , Knudson Alexander M , Korgenski E Kent , Sandweiss David R , Hofmann Michelle G , Glasgow Tiffany S , Coon Eric R
Published: May 2021

BACKGROUND

We implemented an observation unit and home oxygen therapy (OU‐HOT) protocol at our children's hospital during the 2010‐2011 winter season to facilitate earlier discharge of children hospitalized with bronchiolitis. An earlier study demonstrated substantial reductions in inpatient length of stay and costs in the first year after implementation.

OBJECTIVE

Evaluate long‐term reductions in length of stay and cost.

DESIGN, SETTING, AND PARTICIPANTS

Interrupted time‐series analysis, adjusting for patient demographic factors and disease severity. Participants were children aged 3 to 24 months and hospitalized with bronchiolitis from 2007 to 2019.

INTERVENTION

OU‐HOT protocol implementation.

MAIN OUTCOME AND MEASURES

Hospital length of stay. Process measures were the percentage of patients discharged from the OU; percentage of patients discharged with HOT. Balancing measures were 7‐day hospital revisit rates; annual per‐population bronchiolitis admission rates. Secondary outcomes were inflation‐adjusted cost per episode of care and discharges within 24 hours.

RESULTS

A total of 7,116 patients met inclusion criteria. The OU‐HOT protocol was associated with immediate decreases in mean length of stay (–30.6 hours; 95% CI, –37.1 to –24.2 hours) and mean cost per episode of care (–$4,181; 95% CI, –$4,829 to –$3,533). These findings were sustained for 9 years after implementation. Hospital revisit rates did not increase immediately (–1.1% immediate change; 95% CI, –1.8% to –0.4%), but a small increase in revisits was observed over time (change in slope 0.4% per season, 95% CI, 0.1%‐0.8%).

CONCLUSION

The OU‐HOT protocol was associated with sustained reductions in length of stay and cost, representing a promising strategy to reduce the inpatient burden of bronchiolitis.
Automating Measurement of Trainee Work Hours
Authors: Soleimani Hossein , Adler-Milstein Julia , Cucina Russell J , Murray Sara G
Published: May 2021

BACKGROUND: Medical training programs across the country are bound to a set of work hour regulations, generally monitored via self-report.

OBJECTIVE: We developed a computational method to automate measurement of intern and resident work hours, which we validated against self-report.

DESIGN, SETTING, AND PARTICIPANTS: We included all electronic health record (EHR) access log data between July 1, 2018, and June 30, 2019, for trainees enrolled in the internal medicine training program. We inferred the duration of continuous in-hospital work hours by linking EHR sessions that occurred within 5 hours as “on-campus” work and further accounted for “out-of-hospital” work which might be taking place at home.

MAIN OUTCOMES AND MEASURES: We compared daily work hours estimated through the computational method with self-report and calculated the mean absolute error between the two groups. We used the computational method to estimate average weekly work hours across the rotation and the percentage of rotations where average work hours exceed the 80-hour workweek.

RESULTS: The mean absolute error between self-reported and EHR-derived daily work hours for first- (PGY-1), second- (PGY-2), and third- (PGY-3) year trainees were 1.27, 1.51, and 1.51 hours, respectively. Using this computational method, we estimated average (SD) weekly work hours of 57.0 (21.7), 69.9 (12.2), and 64.1 (16.3) for PGY-1, PGY-2, and PGY-3 residents.

CONCLUSION: EHR log data can be used to accurately approximate self-report of work hours, accounting for both in-hospital and out-of-hospital work. Automation will reduce trainees’ clerical work, improve consistency and comparability of data, and provide more complete and timely data that training programs need.
Donosicielstwo, niespełnione ambicje czy zdrada stanu?
Authors: Pudłocki Tomasz
Published: May 2021

Informants, Unfulfilled Ambitions or High Treason? Problems of the Educational Environment of Stanisławów in the Years 1914-1915 in the Light of the Investigation into Michał Jezienicki, the Head of the 1st Gimnasium

The author uses the files from the investigation into Michał Jezienicki, the head of the 1st Gymnasium with Polish as the language of instruction, to take a closer look at the problems faced by the citizens of Stanisławów during the first Russian occupation. The files have allowed to recreate the atmosphere between the members of the school community and answer the question to what extent it was a derivative of the headmaster’s nervousness and to what extent due to the unfulfilled ambitions of Teofil Erben, the German language teacher who initiated the investigation into Jezienicki. Thus, the article shows the problem of informants, widespread during the First World War, and the issue of loyalty to the Habsburg monarchy, which was still considered very profitable by many members of the elite.
Polowania w Karpatach Wschodnich w świetle relacji zamieszczanych na łamach czasopisma „Łowiec”
Authors: Bajda Łukasz
Published: May 2021

Hunting in the Eastern Carpathians in the light of the reports published in the magazine “Łowiec”

“Łowiec” (“Hunter”), the monthly magazine of the Galician Hunting Society issued since 1878, regularly published texts on hunting in the Eastern Carpathians. The hunting appeal of the region was raised by the relatively large brown bear population. The magazine published both longer articles by famous writers and journalists as well as short letters and reports by often anonymous correspondents.