bluuebunny/crossref_metadata_2025 huggingface dataset:
Respiratory difficulty with palatal, laryngeal and respiratory muscle tremor in adult-onset Alexander’s disease
Authors: McAuley John , Taylor Rowena , Simonds Anita , Chawda Sanjiv
Published: April 2017

Sleep apnoea and respiratory difficulties are reported in adult-onset Alexander’s disease (AOAD), an autosomal-dominant leukodystrophy that presents mainly with progressive ataxia. We demonstrate for the first time that the respiratory symptoms can result from association of palatal tremor with a similar tremor of laryngeal and respiratory muscles that interrupts normal inspiration and expiration.

A 60-year-old woman presented with progressive ataxia, palatal tremor and breathlessness. MRI revealed medullary atrophy, bilateral T2 hyperintensities in the dentate nuclei and hypertrophic olivary degeneration (HOD). AOAD was confirmed genetically with a positive glial fibrillary acidic protein (GFAP) mutation. Electrophysiological study revealed 1.5 Hz rhythmic laryngeal and respiratory muscle activity. Her respiratory symptoms were significantly improved at night with variable positive pressure ventilation.

This case illustrates that palatal tremor in AOAD, and potentially in other conditions, may be associated with treatable breathlessness due to a similar tremor of respiratory muscles.
Migration of clips to the colon after laparoscopic partial nephrectomy
Authors: Vedel Peter Fisker , Wittendorf Hans-Erik , Norus Thomas Peter
Published: April 2017

A 78-year-old man was treated with laparoscopic partial nephrectomy for a 4 cm tumour in the lower pole of the left kidney. The patient was discharged 2 days postoperatively. Preoperatively there was no sign of metastasis; the pathology indicated complete removal of the tumour, a renal cell carcinoma. 53 days postoperatively the patient had acute onset of rectal bleeding. A colonoscopy revealed necrosis and three clips on the wall of the colon corresponding to where the descending colon passes over the left kidney. The patient was treated conservatively. Clip migration has been reported previously, but to our knowledge we present the first case of clip migration to the colon after laparoscopic partial nephrectomy. Suggestions to avoid the presented complication are made.
Complicated small bowel diverticular disease: a case series
Authors: Karas Linden , Asif Mohammed , Chun Victor , Khan Farrukh A
Published: April 2017

Small bowel diverticulosis of the jejunum and ileum is an uncommon finding with a prevalence rate of 0.2% to 1.3% at autopsy and 0.3% to 1.9% on small bowel studies. Diagnosis can be difficult because there are no pathognomonic features or clinical symptoms that are specific for small bowel diverticulosis. Though rare, it is critical to keep the possibility of small bowel diverticulosis in mind when evaluating cases of malabsorption, chronic abdominal pain, haemorrhage, perforation and intestinal obstruction, especially in patients with connective tissue disorders, a family history of diverticula and a personal history of colonic diverticulosis. Guidelines for the treatment of complicated small bowel diverticulosis are not clearly defined. However, the consensus in treatment is to do a small bowel resection with primary anastomosis. We report three interesting cases of jejunoileal diverticula that presented in an occult manner and later progressed to more emergent manifestations.
A dynamic look on molecular symmetry
Authors: Barón Máximo , Bain Alex D. , Conde Romina S.
Published: April 2017

J.H. van’t Hoff’s seminal paper variously titled as either: Chemistry in Space, The Placement of Atoms in Space or other with similar wording, depending on the language it was published in, suggested that the structure of a molecule would be independent of its physical state: solid, liquid, vapor, gaseous, or in solution. However, this is definitely not true so much so that during the last decades many examples have accumulated showing that the structure of a molecule in a crystalline solid can differ substantially from its structure in solution. This would have important consequences not only on how molecules are structurally described and the way they react, but also that molecular symmetry may not be a static property and has to be considered from a dynamic point of view. To add additional evidence to this conception, we took advantage of a family of trans-1,4-di- and tetra-substituted cyclohexane derivatives that appear to have a centre of symmetry but show a substantial dipole moment in solution. In the present work, we used the trans-1,4-dicarboxymethylcyclohexane and its 1,4-dibrominated derivative and were able, through dipole moment determinations IR, Raman, NMR studies, and computational calculations with the SpinWorks, MOPAC, and MOLDEN programs, to confirm our assumption that the molecular symmetry and the molecular structure are dependent on the environment.
The McKay Conjecture for Finite Groups with Abelian Sylow 3-Subgroups
Authors: Feng Zhicheng , Li Conghui , Li Zhenye
Published: April 2017

In this paper, we prove that the McKay conjecture holds for finite groups with abelian Sylow 3-subgroups and any prime ℓ via the inductive McKay condition.
On Free Pre-Lie Algebras
Authors: Li Yu , Mo Qiuhui
Published: April 2017

In this paper, we find Hall-Shirshov type bases for free pre-Lie algebras. We show that Segal’s basis of a free pre-Lie algebra is a type of these bases. We give a nonassociative Gröbner-Shirshov basis S for a free pre-Lie algebra such that Irr(S) is a monomial basis (called normal words) of a free pre-Lie algebra, where Irr(S) is the set of all nonassociative words, not containing maximal nonassociative words of polynomials from S. We establish the Composition-Diamond lemma for free pre-Lie algebras over the basis of normal words and the degree breadth lexicographic ordering.
Automorphisms and Verma Modules for Generalized 2-dim Affine-Virasoro Algebra
Authors: Ruan Wenlan , Zhang Honglian , Sun Jiancai
Published: April 2017

We study the structure of the generalized 2-dim affine-Virasoro algebra, and describe its automorphism group. Furthermore, we also determine the irreducibility of a Verma module over the generalized 2-dim affine-Virasoro algebra.
Jacobson’s Lemma via Gröbner-Shirshov Bases
Authors: Zhao Xiangui
Published: April 2017

Let R be a ring with identity 1. Jacobson’s lemma states that for any [Formula: see text], if 1− ab is invertible then so is 1 − ba. Jacobson’s lemma has suitable analogues for several types of generalized inverses, e.g., Drazin inverse, generalized Drazin inverse, and inner inverse. In this note we give a constructive way via Gröbner-Shirshov basis theory to obtain the inverse of 1 − ab in terms of (1 − ba)−1, assuming the latter exists.
C2-Cofiniteness of Cyclic-Orbifold Vertex Operator Superalgebras
Authors: Ai Chunrui
Published: April 2017

In this paper, it is proved that for any C2-cofinite, simple, CFT-type vertex operator superalgebra V and a finite solvable group G consisting of automorphisms of V, the fixed point subalgebra VG is a C2-cofinite vertex operator superalgebra.
A New Composition-Diamond Lemma for Dialgebras
Authors: Zhang Guangliang , Chen Yuqun
Published: April 2017

Bokut, Chen and Liu in 2010 gave a Composition-Diamond lemma for dialgebras. In this paper, by introducing an arbitrary monomial-center ordering, we give a new Composition-Diamond lemma for dialgebras which makes the two conditions in Bokut, Chen and Liu’s result equivalent. The new lemma is more useful and convenient than the one Bokut, Chen and Liu got. We show that every ideal of the free dialgebra generated by a set X has a unique reduced Gröbner-Shirshov basis. As applications, we give a method to find normal forms of elements of an arbitrary disemigroup, in particular, two Zhuchoks’ normal forms of the free commutative disemigroups and the free abelian disemigroups, and normal forms of the free left (right) commutative disemigroups.
Class-Preserving Coleman Automorphisms of Finite Groups with Prescribed Centralizers
Authors: Li Zhengxing , Gao Hongwei
Published: April 2017

Let G be a finite group. It is proved that any class-preserving Coleman automorphism of G is an inner automorphism whenever G belongs to one of the following two classes of groups: (1) CN-groups, i.e., groups in which the centralizer of any element is nilpotent; (2) CIT-groups, i.e., groups of even order in which the centralizer of any involution is a 2-group. In particular, the normalizer conjecture holds for both CN-groups and CIT-groups. Additionally, some other results are also obtained.
On Obstructing Obscenity Obfuscation
Authors: Rojas-Galeano Sergio
Published: April 2017

Obscenity (the use of rude words or offensive expressions) has spread from informal verbal conversations to digital media, becoming increasingly common on user-generated comments found in Web forums, newspaper user boards, social networks, blogs, and media-sharing sites. The basic obscenity-blocking mechanism is based on verbatim comparisons against a blacklist of banned vocabulary; however, creative users circumvent these filters by obfuscating obscenity with symbol substitutions or bogus segmentations that still visually preserve the original semantics, such as writing
shit
as
$h¡;t
or
s.h.i.t
or even worse mixing them as
$.h….¡.t
. The number of potential obfuscated variants is combinatorial, yielding the verbatim filter impractical. Here we describe a method intended to obstruct this anomaly inspired by sequence alignment algorithms used in genomics, coupled with a tailor-made edit penalty function. The method only requires to set up the vocabulary of plain obscenities; no further training is needed. Its complexity on screening a single obscenity is linear, both in runtime and memory, on the length of the user-generated text. We validated the method on three different experiments. The first one involves a new dataset that is also introduced in this article; it consists of a set of manually annotated real-life comments in Spanish, gathered from the news user boards of an online newspaper, containing this type of obfuscation. The second one is a publicly available dataset of comments in Portuguese from a sports Web site. In these experiments, at the obscenity level, we observed recall rates greater than 90%, whereas precision rates varied between 75% and 95%, depending on their sequence length (shorter lengths yielded a higher number of false alarms). On the other hand, at the comment level, we report recall of 86%, precision of 91%, and specificity of 98%. The last experiment revealed that the method is more effective in matching this type of obfuscation compared to the classical Levenshtein edit distance. We conclude discussing the prospects of the method to help enforcing moderation rules of obscenity expressions or as a preprocessing mechanism for sequence cleaning and/or feature extraction in more sophisticated text categorization techniques.
IONavi
Authors: Teng Xiaoqiang , Guo Deke , Guo Yulan , Zhou Xiaolei , Ding Zeliu , Liu Zhong
Published: April 2017

The proliferation of mobile computing has prompted navigation to be one of the most attractive and promising applications. Conventional designs of navigation systems mainly focus on either indoor or outdoor navigation. However, people have a strong need for navigation from a large open indoor environment to an outdoor destination in real life. This article presents IONavi, a joint navigation solution, which can enable passengers to easily deploy indoor-outdoor navigation service for subway transportation systems in a crowdsourcing way. Any self-motivated passenger records and shares individual walking traces from a location inside a subway station to an uncertain outdoor destination within a given range, such as one kilometer. IONavi further extracts navigation traces from shared individual traces, each of which is not necessary to be accurate. A subsequent following user achieves indoor-outdoor navigation services by tracking a recommended navigation trace. Extensive experiments are conducted on a subway transportation system. The experimental results indicate that IONavi exhibits outstanding navigation performance from an uncertain location inside a subway station to an outdoor destination. Although IONavi is to enable indoor-outdoor navigation for subway transportation systems, the basic idea can naturally be extended to joint navigation from other open indoor environments to outdoor environments.
Expression of uPAR in Urinary Podocytes of Patients with Fabry Disease
Authors: Trimarchi Hernán , Canzonieri Romina , Schiel Amalia , Politei Juan , Costales-Collaguazo Cristian , Stern Aníbal , Paulero Matías , Rengel Tatiana , Valiño-Rivas Lara , Forrester Mariano , Lombi Fernando , Pomeranz Vanesa , Iriarte Romina , Muryan Alexis , Ortiz Alberto , Sanchez-Niño María Dolores , Zotta Elsa
Published: April 2017

Background. Despite enzyme replacement therapy, Fabry nephropathy still progresses. Podocyturia is an irreversible event that antedates proteinuria and leads to chronic renal failure. We evaluated a potential mechanism of podocyte detachment via the expression of the urokinase-type Plasminogen Activator Receptor (uPAR) in urinary podocytes of Fabry patients.Methods. This is a cross-sectional study that included controls (n=20) and Fabry patients (n=44) either untreated (n=23) or treated with agalsidase-β(n=21).Variables. Variables are estimated glomerular filtration rate (eGFR), urinary protein : creatinine ratio, and urinary uPAR+ podocyte : creatinine ratio. uPAR mRNA expression in response to lyso-Gb3, a bioactive glycolipid accumulated in Fabry disease, was studied in cultured human podocytes.Results. Controls and Fabry patients had similar age, gender, and renal function. Urinary uPAR+ podocytes were higher in patients than in controls. Untreated patients were significantly younger; had more females, and presented lower urinary protein : creatinine ratios and significantly higher urinary uPAR+ podocytes than treated subjects. In treated patients, urinary uPAR+ podocytes correlated with urinary protein : creatinine ratio (ρ=0.5;p=0.02). Lyso-Gb3 at concentrations found in the circulation of Fabry patients increased uPAR expression in cultured podocytes.Conclusions. Urinary podocytes expressing uPAR are increased in Fabry patients, especially in untreated patients. The potential contribution of uPAR expression to podocyte detachment merits further studies.
Comparative Response of the Nigerian Indigenous and Broiler Chickens to a Field Caecal Isolate of Eimeria Oocysts
Authors: Atehmengo Ngongeh Lucas , Onyeabor Amaechi , Nzenwata Emeka , Samson Gurama Kansalem
Published: April 2017

Response of Nigerian indigenous (local) and broiler chickens to experimental Eimeria infections was investigated by measures of clinical signs, packed cell volume (PCV), body weights (BW), feed consumption, faecal oocyst counts (oocyst per gram), and microscopic intestinal lesions. Three-week-old chickens of each breed received single pulse infections with 2500, 5000, and 100.000 sporulated Eimeria oocysts. Infected birds were dull and passed bloody diarrhoea. OPG showed a dose related response but no significant difference between groups (P>0.05). OPG was significantly higher in local chickens (P<0.05) and varied significantly with time (P<0.05). PCV declined significantly in infected birds within breeds and groups (P<0.05); however, the decline in PCV was significantly greater in broilers (P<0.05). Both breeds had significant BW gains (P<0.05). BW gain varied between groups being significantly higher in the uninfected control broilers than in the infected broilers (P<0.05). Comparatively, broilers gained significantly more BW than their local counterparts (P<0.05). Feed intake increased significantly with time (P<0.05) in both breeds. The Eimeria isolate was pathogenic to both breeds of chicken although clinical signs and lesions were more severe in indigenous chickens suggesting the breed’s more susceptibility.
Improving the Robustness of Real-Time Myoelectric Pattern Recognition against Arm Position Changes in Transradial Amputees
Authors: Geng Yanjuan , Samuel Oluwarotimi Williams , Wei Yue , Li Guanglin
Published: April 2017

Previous studies have showed that arm position variations would significantly degrade the classification performance of myoelectric pattern-recognition-based prosthetic control, and the cascade classifier (CC) and multiposition classifier (MPC) have been proposed to minimize such degradation in offline scenarios. However, it remains unknown whether these proposed approaches could also perform well in the clinical use of a multifunctional prosthesis control. In this study, the online effect of arm position variation on motion identification was evaluated by using a motion-test environment (MTE) developed to mimic the real-time control of myoelectric prostheses. The performance of different classifier configurations in reducing the impact of arm position variation was investigated using four real-time metrics based on dataset obtained from transradial amputees. The results of this study showed that, compared to the commonly used motion classification method, the CC and MPC configurations improved the real-time performance across seven classes of movements in five different arm positions (8.7% and 12.7% increments of motion completion rate, resp.). The results also indicated that high offline classification accuracy might not ensure good real-time performance under variable arm positions, which necessitated the investigation of the real-time control performance to gain proper insight on the clinical implementation of EMG-pattern-recognition-based controllers for limb amputees.
An Unusual Presentation of Congenital Lobar Emphysema
Authors: Arnaud Daniel , Varon Joseph , Surani Salim
Published: April 2017

Congenital lobar emphysema is an uncommon bronchopulmonary malformation characterized by lobar overinflation and accompanying alveolar septum damage that leads to compression atelectasis of the lung parenchyma and displacement of mediastinal structures, with the resultant ventilation-perfusion mismatch. We present a case of a 33-year-old lady with progressive exertional dyspnea. Chest radiograph findings lead to the suspicion of congenital lobar emphysema, which was then confirmed by a computed tomography (CT) scan. This condition is most commonly identified in newborns, with very few cases being reported in adults. Lobectomy remains the treatment of choice and in general has good outcome.
The Effect of L-Carnitine, Hypotaurine, and Taurine Supplementation on the Quality of Cryopreserved Chicken Semen
Authors: Partyka Agnieszka , Rodak Olga , Bajzert Joanna , Kochan Joanna , Niżański Wojciech
Published: April 2017

The objective of this study was to investigate the effect of L-carnitine (LC), hypotaurine (HT), and taurine (T) on the quality of frozen-thawed chicken semen. Pooled semen samples were divided into seven aliquots (control, 1 mM LC, 5 mM LC, 1 mM HT, 10 mM HT, 1 mM T, and 10 mM T) and subjected to cryopreservation. Postthaw sperm motility was determined by IVOS system and sperm characteristics were assessed with fluorochromes and flow cytometry. The highest sperm motility and the highest percentage of viable sperm were in the HT1 group (P<0.01andP<0.05) following cryopreservation. After thawing, we observed a higher percentage of sperm without apoptosis and membrane reorganization changes in the LC1 and T1 group when compared to the control (P<0.05). There was a higher percentage of live sperm without lipid peroxidation (LPO) in all treatments (P<0.01;P<0.05), when compared to the control group. The percentage of sperm with high mitochondrial potential significantly increased with LC1, T1, and T10 (P<0.05). Supplementation of the diluent with LC1, LC5, and T1 significantly (P<0.05) reduced DNA susceptibility to fragmentation, compared to the control and HT1 groups. These results indicate that the addition of examined antioxidants improves the quality of cryopreserved chicken semen.
Chondrocyte-Specific Knockout of TSC-1 Leads to Congenital Spinal Deformity in Mice
Authors: Yang Cheng , Chen Yuhui , Li Zhen , Cao He , Chen Keming , Lai Pinglin , Yan Bo , Huang Bin , Tang Jiajun , Fan Shicai , Cai Daozhang , Jin Dadi , Bai Xiaochun , Zhou Rongping
Published: April 2017

Congenital spinal deformity is the most severe clinical orthopedic issue worldwide. Among all the pathological processes of congenital spinal deformity, the imbalance of endochondral ossification is considered to be the most important developmental cause of spinal dysplasia. We established chondrocyte-specific TSC-1 knockout (KO) mice to overactivate the energy metabolic component, mammalian target of rapamycin complex 1 (mTORC1), and measured the spinal development by general, imaging, histological, and Western-blot assessments. In addition to skeletal dysplasia, the KO mice displayed severe congenital spinal deformity and significant intervertebral disc changes. This study suggests that, in the process of endochondral ossification, excessive activation of mTORC1 signaling in chondrocytes induces obvious spinal deformity, and the chondrocytes may be the cell type responsible for congenital spinal deformity.
Forsaken Foregut: Case Report of Simultaneous Black Esophagus and Ischemic Cholangiopathy
Authors: Cameron Paul A. , Schweiger Franzjosef
Published: April 2017

Black esophagus or acute esophageal necrosis rarely occurs after severe hemodynamic compromise or low-flow states. Other contributing factors may include corrosive injury from gastric contents and diminished mucosal repair mechanisms. Ischemic cholangitis, another rare clinical entity, is also usually the result of a significant vascular and/or hypotensive insult to the biliary tree. We describe the first case of combined acute esophageal necrosis and ischemic cholangiopathy in a 62-year-old male who completely recovered from the esophageal injury but developed progressive liver failure from ischemic cholangiopathy.
Bioactive Compounds, Antioxidant Capacity, and Fatty Acids in Different Parts of Four Unexplored Fruits
Authors: Rydlewski Adriela Albino , de Morais Damila Rodrigues , Rotta Eliza Mariane , Claus Thiago , Vagula Julianna Matias , da Silva Michele Cristina , Santos Junior Oscar Oliveira , Visentainer Jesuí Vergílio
Published: April 2017

Total phenolic content (TPC), total flavonoids (TF), total anthocyanins (TA), and antioxidant capacity of different parts of four unexplored fruits from Brazil (Syzygium cuminiLam,Solanum nigrumLinn,Inga edulisMart, andHovenia dulcisThunb) were determined; the bioactive compounds and fatty acids were quantified and identified by high-performance liquid chromatography and gas chromatography, respectively.S. cuminipeels contained the most TA (63.31 mg/100 g), whilstH. dulcispulp and peels had the highest TPC (518.18 mg GAE/100 g) and TF (76.54 mg EQ/g). Phenolic compounds responsible for antioxidant capacity of fruits were gallic acid, ellagic acid, kaempferol, and epicatechin.H. dulcisseed showed the highest level of the essential fatty acid omega-3 (3985.95 mg/100 g). PCA showed that PC1 and PC2 explained 90.43% of the total variability of the antioxidant data. Most of the seeds showed omega-3, omega-6, and omega-9 fatty acids at significant concentrations, with two PCs explaining 93.80% of the total variance of the fatty acid contents.
Sarcoidosis: Is It a Possible Trigger of Inclusion Body Myositis?
Authors: Zakaria Ali , Turk Issam , Leung Kenneth , Capatina-Rata Ana , Farra Waseem
Published: April 2017

Sarcoidosis is a multisystem disorder of unknown etiology, characterized pathologically by the presence of nonnecrotizing granulomatous inflammation in affected organs. Although skeletal muscle is involved in 50–80 percent of individuals with sarcoidosis, symptomatic myopathy has been shown to be a rare manifestation of the disease. Inclusion body myositis (IBM) is a rare acquired idiopathic inflammatory myopathy with the insidious onset of asymmetric and distal muscle weakness that characteristically involves the quadriceps, tibialis anterior, and forearm flexors. Moreover, dysphagia can be the presenting complaint in one-third of patients. Herein, we are presenting a case of 67-year-old African American female who presented with one-month history of new onset progressive dyspnea on exertion. She was diagnosed with stage IV sarcoidosis based on chest CT scan findings and transbronchial lung biopsy revealing nonnecrotizing granulomatous inflammation. Over the next three months after her diagnosis, she presented to the hospital with progressive dysphagia associated with asymmetrical distal muscle weakness. A quadriceps muscle biopsy revealed features consistent with inclusion body myositis. We are reporting this case as it may support the hypothesis of sarcoidosis being a trigger that possibly promotes the development of inclusion body myositis, leading to a very poor prognosis.
A Novel Theoretical Life Course Framework for Triggering Cognitive Development across the Lifespan
Authors: Wu Rachel , Rebok George W. , Lin Feng Vankee
Published: April 2017

Although intellectual engagement is a significant factor associated with adult cognitive health, it is unclear what it includes, why and how it declines across the lifespan, and importantly, whether its decline has a causal role in cognitive aging. This integrative review introduces a novel theoretical life course framework that synthesizes research on early childhood experiences and cognitive aging to address the following three points. First, we specify six critical factors of intellectual engagement for long-term, broad cognitive development: (a) open-minded input-driven learning, (b) individualized scaffolding, (c) growth mindset, (d) forgiving environment, (e) serious commitment to learning, and (f) learning multiple skills simultaneously. We show that these factors increase basic cognitive abilities (e.g., working memory, inhibition) and promote far transfer. Second, we trace the decline of the six factors from infancy to aging adulthood (broad learning to specialization). Finally, we propose that these six factors can be applied to expand cognitive functioning in aging adults beyond currently known limits.
Evacuation of a Tertiary Neonatal Centre: Lessons from the 2016 Kumamoto Earthquakes
Authors: Iwata Osuke , Kawase Akihiko , Iwai Masanori , Wada Kazuko
Published: April 2017

Background: Newborn infants hospitalised in the neonatal intensive care unit (NICU) are vulnerable to natural disasters. However, publications on evacuation from NICUs are sparse. The 2016 Kumamoto Earthquakes caused serious damage to Kumamoto City Hospital and its level III regional core NICU. Local/neighbour NICU teams and the disaster-communication team of a neonatal academic society cooperated to evacuate 38 newborn infants from the ward. Objective: The aim of this paper was to highlight potential key factors to improve emergency NICU evacuation and coordination of hospital transportation following natural disasters. Methods: Background variables including clinical risk scores and timing/destination of transportation were compared between infants, who subsequently were transferred to destinations outside of Kumamoto Prefecture, and their peers. Results: All but 1 of the infants were successfully evacuated from their NICU within 8 h. One very-low-birth-weight infant developed moderate hypothermia following transportation. Fourteen infants were transferred to NICUs outside of Kumamoto Prefecture, which was associated with the diagnosis of congenital heart disease, dependence on respiratory support, higher risk scores, and longer elapsed time from the decision to departure. There was difficulty in arranging helicopter transportation because the coordination office of the Disaster Medical Assistance Team had requisitioned most air/ground ambulances and only helped arrange ground transportations for 13 low-risk infants. Transportation for all 10 high-risk infants (risk scores greater than or equal to the upper quartile) was arranged by local/neighbour NICUs. Conclusions: Although the overall evacuation process was satisfactory, potential risks of relying on the adult-based emergency transportation system were highlighted. A better system needs to be developed urgently to put appropriate priority on vulnerable infants.
Early Thrombectomy of a Proximal Middle Cerebral Artery Occlusion Leading to Complete Recovery with No Infarct
Authors: Myren-Svelstad Sverre , Hammer Tommy A. , Idicula Titto T.
Published: April 2017

Many recent trials show the benefit of mechanical thrombectomy in acute ischemic stroke caused by thrombi lodged in large arteries. We report the case of a 55-year-old patient who developed sudden-onset right-sided hemiplegia and aphasia. Computed tomography angiography showed a thrombus in the M1 segment of the left middle cerebral artery. The thrombus was removed by mechanical thrombectomy 85 min after the onset of symptoms. A magnetic resonance imaging (MRI) scan showed no infarct, and the patient was discharged symptom free. To the best of our knowledge, this is the first report of thrombectomy of a symptomatic proximal middle cerebral artery occlusion leading to complete rescue, both clinically and radiologically assessed by MRI. Our case report shows that an early thrombectomy can provide an excellent outcome.
Choreoathetosis Is a Possible Adverse Event of a Commonly Used Antibiotic
Authors: Sathirapanya Pornchai
Published: April 2017

Background: Choreoathetosis (CAS) is attributed to a few neuropsychiatric drugs; however, it is scarcely reported with commonly used antibiotics. Aims: To present a case of ceftriaxone (CTX)-induced CAS and to perform a literature review. Setting: A medical teaching hospital. Case History: An 83-year-old female with end stage renal disease was prescribed CTX 2 g/day intravenously and doxycycline (DXC) 200 mg/day orally for the treatment of acute community-acquired systemic infection. CAS developed 3 days after the administration of both drugs. Withdrawal of CTX and DXC yielded complete resolution of the CAS on the following day. Neither neurological adverse events related to DXC use nor pharmacological interaction between DXC and CTX was reported. Therefore, the CAS development was attributed to CTX. Conclusion: CTX as well as other ß-lactam antibiotics induce glutamate excess in the striatum and cerebral cortex, resulting in neurological hyperexcitability disorders. Dosage adjustment of these antibiotics in relation to the patients’ renal clearance is warranted.
Sarcoidosis-Lymphoma Syndrome Associated with Folliculotropic Peripheral T Cell Lymphoma Not Otherwise Specified
Authors: Yoshida Saaya , Fujimura Taku , Kambayashi Yumi , Furudate Sadanori , Mizuashi Masato , Aiba Setsuya
Published: April 2017

Sarcoidosis is occasionally accompanied by hematologic malignancies, including cutaneous T-cell lymphoma, called sarcoidosis-lymphoma syndrome. Although the mechanism underlying the induction of lymphomas is still unknown, understanding the immunological background of sarcoidosis could help explain the possible mechanisms of the induction of lymphomas. In this report, we describe a case of sarcoidosis-lymphoma syndrome associated with folliculotropic peripheral T cell lymphoma not otherwise specified, which caused dense infiltration of CD30+ CD163+ tumor-associated macrophages (TAMs) only in the lesional skin. Our present case might suggest the significance of TAMs in developing sarcoid-lymphoma syndrome.
Serum G-CSF May Be a More Valuable Biomarker than Image Evaluation in G-CSF-Producing Urothelial Carcinoma: A Case Report
Authors: Morozumi Kento , Namiki Shunichi , Kudo Takashi , Aizawa Masataka , Ioritani Naomasa
Published: April 2017

Granulocyte colony-stimulating factor (G-CSF)-producing urothelial carcinomas (UCs) are rare and have a poor prognosis. According to the literature, treatment for G-CSF-producing UCs is very difficult. We experienced 2 cases of UC presenting with leukocytosis. In these cases, serum G-CSF levels were higher than the reference value with leukocytosis at diagnosis, and the resected specimens were positive for anti-G-CSF immunostaining. One case had a good prognosis and the other case died after 9 months from diagnosis. A change in serum G-CSF levels was reportedly an effective tumor marker in several reports. In the present cases, evaluation of serum G-CSF levels was found to be more sensitive than computerized tomography. The treatment and outcomes of UC-producing G-CSFs and the efficacy of serum G-CSF as a tumor marker are discussed based on our cases and a review of the literature.
Detection of Renal Hypoxia in Lupus Nephritis Using Blood Oxygen Level-Dependent MR Imaging: A Multiple Correspondence Analysis
Authors: Shi Huilan , Yan Tiekun , Li Dong , Jia Junya , Shang Wenya , Wei Li , Zheng Zhenfeng
Published: April 2017

Background/Aims: Nephrologists have pursued ideal, dynamic and noninvasive methods for assessing renal function and disease progression. Blood oxygen level dependent (BOLD) imaging is a useful technique for assessing renal disease. This current study was performed to explore the correlation between the hypoxia iconographical index and renal pathological features in lupus nephritis. Methods: Adult patients with lupus nephritis (LN) and healthy volunteers were recruited for this study. Renal biopsy tissues were characterized based on the LNISN/RPS 2003 classification. R2* values of functional magnetic resonance parameters were acquired using the BOLD technique. The data characteristics of R2* values of different pathological patterns were calculated. Multiple correspondence analysis (MCA) was performed to explore the correlation between R2* values and clinical or pathological features. Results: A total of twenty-three patients and eighteen healthy volunteers were examined with BOLD MRI. Renal pathological patterns included five class III (including 3 class III+V), eight class IV (including 4 class IV+V) and five class IV. The mean renal R2* values in LN patients were higher than those in healthy volunteers. R2* values in class V patients were higher than those in class IV and class III. The MCA showed that higher R2* values were associated with pathological features in class V patients. Conclusions: The extent of renal hypoxia in patients with LN was more serious compared with the healthy volunteers. Differentiated mechanisms of renal oxygenation are possibly involved in proliferative and non-proliferative LN patients. R2* values may be linked with multiple clinical and pathological indexes.
Efeito da hipomagnesemia e da suplementação de magnésio sobre a insuficiência renal aguda pós-isquêmica
Authors: Silva Josenalva Cassiano da , Seguro Antonio Carlos
Published: April 2017

Hipótese: Este trabalho visa avaliar os efeitos da hipomagnesemia e da suplementação de magnésio nainsuficiência renal aguda pós- isquêmica. Materiais e Métodos: Foram utilizados ratos machos Wistar, divididos emcinco grupos: controle, hipomagnesêmico, isquêmico, hipoMg+ isquêmico, suplementado + isq. Foi feito o estudo de clearance de inulina e a determinação de medidas funcionais. Resultados: A hipomagnesemia no contexto de uma isquemia renal levou a uma queda mais acentuada do RFG (Cin) e FSR e aumento da RVR. Nos animaissuplementados, houve um aumento dos valores de Cin e FeH2O. Conclusões: A hipomagnesemia na insuficiênciarenal aguda (IRA) potencializa os efeitos desta sobre a função renal. A suplementação de Magnésio protege parcialmente dos efeitos da IRA pós-isquêmica.
Efeito da escala MELD na mortalidade após transplante de fígado
Authors: Fernandes Jorge Henrique , Millan Lincoln Saito , Massarollo Paulo Celso Bosco , Mies Sérgio
Published: April 2017

A alta mortalidade na lista de espera por transplante de fígado (Tx) tem estimulado a adoção de critérios degravidade para alocação de órgãos. O objetivo desse trabalho é investigar qual o efeito da classificação MELD (Modelfor End-Stage Liver Disease) na mortalidade após o Tx. Foram revisados 237 casos de Tx eletivo com doador cadáverrealizados entre 1º/11/1995 e 30/7/2001. Na análise de regressão logística, foi encontrada uma interação significanteentre a pontuação MELD e a mortalidade nos primeiros 6 meses após o transplante (odds ratio = 1,052; IC95% = 1,015 a 1,090; p = 0,02). Para estudar o efeito da escala MELD na sobrevida atuarial, os pacientes foram divididos em dois grupos: Grupo A (n = 126) com valores de MELD abaixo da média da casuística global (14,4) e Grupo B (n = 111) compontuação MELD acima desse valor. Existe uma diferença significante entre a sobrevida ao longo do tempo nos doisgrupos (p = 0,0374). A análise de regressão proporcional de Cox indicou risco 1,65 vezes maior no grupo B (riscorelativo = 1,6523; IC95% = 1,0240 a 2,6662).
Prevenção da reestenose pós-angioplastia coronária: mito ou realidade?
Authors: Santos Filho Edson Guilherme dos , Abdo Guilherme Lozi , Orel Milton , Gun Carlos
Published: April 2017

A doença arterial coronária é a principal causa de óbito em ambos os sexos em nações industrializadas. A maioria destas mortes ocorre devido à aterosclerose das artérias coronárias. A medida terapêutica mais eficaz para a aterosclerose obstrutiva é a Angioplastia Percutânea Transluminal Coronária (APTC) com a utilização de stent. Entretanto, esta terapia vem encontrando limitações em seu sucesso, pois em 30 a 50% dos casos de implantação de stent ocorre a principal complicação deste procedimento – a reestenose. Inúmeros fármacos têm sido testados com o propósito de prevenir o processo reestenótico, porém o sucesso foi pequeno quando comparado às taxas de reestenose encontradas. Estes fármacos podem ser divididos em dois grupos, os de ação sistêmica e local. Os sistêmicos não apresentaram resultados satisfatórios, uma vez que as taxas variaram de 9,5 a 40% na prevenção da reestenose. Já as drogas de liberação local, através do revestimento de stent com substâncias liberadas lentamente, os resultados foram significativos. Os principais fármacos estudados neste grupo incluem a Rapamicina e Paclitaxel. Este obteve resultados importantes na proliferação das camadas íntima e média, alcançando taxa de reestenose de 4%. Já a Rapamicina, através da inibição da proliferação de células musculares lisas tem importante papel naprevenção da neoformação intimal, confirmado através da realização de estudos randomizados e duplo-cegos (RAVEL),nos quais constatou-se taxa de reestenose nunca antes observada na cardiologia intervencionista – 0%. Apesar deresultados promissores, há necessidade de maiores estudos clínicos para definir a real efetividade desta droga naprevenção da reestenose pós APTC.
Mutação do Gene p53 induzindo predisposição hereditária ao câncer: relato de um caso da síndrome de Li-Fraumeni
Authors: Pinto Fernanda Nunes , Prudente Fernanda Vilas Boas , Gonçalves Marina Sahade , Silva Priscilla Domene Vaccaro , Del Giglio Auro
Published: April 2017

A Síndrome de Li-Fraumeni é uma síndrome de predisposição familiar ao câncer, caracterizada pela presença de múltiplos tumores, tais como sarcomas, carcinomas de mama, tumores cerebrais e leucemia. O caso relatado é de uma paciente feminina de 37 anos, que apresenta uma significativa história familiar de câncer, bem como história pessoal de seis diferentes tumores primários (um de cólon, um nevus displásico, um de ovário e três de mama). O seqüenciamento do gene supressor de tumor p53 em seus linfócitos presentes no sangue periférico revelou uma mutação do aminoácido triptofano (TGG) para um códon de parada prematuro (TAG), no nucleotídeo 437 do códon 146 do exon 5 deste gene. As implicações clínicas, preventivas e éticas deste caso são também abordadas.
Apartamentos duplex: modernidade, usos e conservação
Authors: Costa Sabrina Studart Fontenele
Published: April 2017

Este trabalho pretende discutir a preservação dos apartamentos duplex modernos na cidade de São Paulo. Símbolos de um modo de viver moderno, esses espaços anunciavam as novas possibilidades de desenho e de organização doméstica. Os primeiros exemplares foram projetados como uma maneira de arranjar espaços habitacionais com áreas pequenas, sua organização em níveis permitia a separação entre setores de atividades da casa e economizava paradas de elevador. O conjunto habitacional soviético Narkonfim (1928-1929) foi pioneiro, mas foi a Unidade de Habitação de Marselha (1945-1952) que ganhou destaque internacional. Os dois conjuntos habitacionais buscavam suprir a demanda habitacional das grandes metrópoles. No Brasil, as primeiras iniciativas associadas aos apartamentos dúplex vinculavam-se às iniciativas governamentais de produção de moradia. No entanto, outros empreendimentos modernos com essa tipologia foram propostos na cidade de São Paulo, com áreas maiores, em localizações privilegiadas, voltados para um público de alto poder aquisitivo. A análise aqui proposta buscará apresentar as transformações físicas pelas quais passaram alguns exemplares desses apartamentos para compreender as adaptações aos hábitos, rotinas e modos de vida dos proprietários e moradores no contexto atual.
A restauração do Conjunto Residencial do Pedregulho: trajetória da arquitetura moderna e o desafio contemporâneo
Authors: Nascimento Flávia Brito do
Published: April 2017

O Conjunto Residencial do Pedregulho, construído na década de 1940 pelo Departamento de Habitação Popular do Rio de Janeiro, é uma das obras mais emblemáticas da arquitetura moderna brasileira. De autoria de Affonso Eduardo Reidy, representa como o desafio de oferecer habitação social foi enfrentado no país. Constituído como unidade de vizinhança, foi projetado para ter todos os serviços adjacentes à moradia em um único quarteirão: edifícios residenciais, escola, ginásio, piscina, posto de saúde, lavanderia e mercado. Divulgado nas principais revistas internacionais de arquitetura e reconhecido como ícone desde sua construção até sua restauração nos anos 2000, teve uma trajetória conturbada. Sofrendo com a falta de verbas para a construção, levou muitos anos para ser concluído, e, mesmo assim, em caráter parcial. A ausência de manutenção levou ao rápido estado de degradação física de muitas das edificações que o compõe. Embora tombado nos níveis municipal e estadual, o processo e o projeto para sua restauração levou alguns anos para se concluir e impôs muitos desafios. Em 2000 começaram as tentativas de restauração deste bem cultural, que levou uma década para ser concluída. Em 2015 a restauração do “Bloco A” foi finalizada, uma inédita realização neste campo para a habitação popular. Dentre os inúmeros conjuntos residenciais construídos no Brasil e na América Latina, a restauração do Pedregulho tem caráter pioneiro. O presente trabalho pretende discutir a restauração do Conjunto Residencial Pedregulho à luz de sua história, de seu projeto e de seus moradores, buscando apresentar as opções adotadas.
Habitação coletiva moderna no Rio de Janeiro: considerações sobre sua preservação
Authors: Coelho Carla Maria Teixeira
Published: April 2017

O tema da habitação coletiva foi o foco principal da produção dos arquitetos e urbanistas durante o Movimento Moderno. Os edifícios residenciais multifamiliares tornaram-se, a partir do século XX, um dos elementos mais representativos na formação da paisagem dos centros urbanos. Com o crescente debate sobre a preservação do legado do Movimento Moderno, muitos edifícios residenciais modernos vêm sendo reconhecidos, em diversos países do mundo, como patrimônio a ser preservado. No Brasil, em geral esse tipo de reconhecimento tem acontecido no âmbito estadual ou municipal. O presente trabalho tem como objetivo traçar uma breve trajetória dos edifícios de habitação coletiva no Rio de Janeiro, enfatizando as principais mudanças trazidas pelos arquitetos do Movimento Moderno. Apresenta uma análise de suas características particulares e discute ações em andamento para sua preservação.
Requalificação do Edifício Riachuelo no Centro Histórico de São Paulo
Authors: Bruna Paulo Julio Valentino , Gouveia Sonia Maria Milani
Published: April 2017

O Edifício Riachuelo foi projetado e construído entre 1942 e 1945 pelos engenheiros Lindenberg & Assumpção, com 17 pavimentos. O primeiro proprietário foi a Associação de Empregados do Comércio de São Paulo, que ocupava apenas alguns andares com atividades sociais. Os demais foram vendidos. O espaço ocupado pela Associação, após 1978, foi utilizado por uma escola de contabilidade e, quando esta saiu, o edifício foi ficando pouco a pouco vazio. Em 1994, foi invadido por moradores de rua. A expulsão dos invasores pelos policiais acarretou uma profunda depredação do imóvel, com destruição de portas, janelas, sanitários, elevadores e prumadas de águas pluviais. A Prefeita Marta Suplicy, durante seu governo (2000/2004), iniciou o programa Morar no Centro, que visava a ocupação do centro histórico, não apenas por setores da administração municipal, mas também por moradores em um sistema de “locação social”. Em 2004, o escritório Paulo Bruna Arquitetos foi contratado pela Cohab-SP para reabilitar o edifício. A área do terreno é de 516m2 e a área total construída é de 7.870,54m2. A recuperação procurou respeitar a lógica construtiva original. Entre os salões de escritórios havia paredes de alvenarias de tijolos maciços que foram mantidas porque são integradas no contraventamento da estrutura. Assim, basicamente cada escritório transformou-se em um apartamento. Foi possível acomodar 120 unidades, variando de 28m2 a 48m2 de área útil. Muitos têm balcões e portas-janelas privativas, que foram mantidos, pois a fachada foi classificada como bem de valor histórico. Os apartamentos acabaram sendo vendidos e os moradores valorizam e conservaram o condomínio de maneira exemplar.
Morar no patrimônio
Authors: Almeida Eneida
Published: April 2017

Este texto sintetiza e comenta a troca de experiências entre moradores de três casas reconhecidas como patrimônio cultural: Doris Lenate, da Vila Maria Zélia; Boris Fausto, falando de sua própria residência, projetada por Sergio Ferro; e Beatriz Millan, apresentando a casa Roberto Millan, projetada por Carlos Millan. José Cazarin, diretor da Imobiliária Axpe, contribui para o debate com a exposição de seu trabalho de comercialização de bens culturais.