bluuebunny/crossref_metadata_2025 huggingface dataset:
Phenomenology of the professional crisis of the teacher during the online learning
Authors: Sadovnikova Nadezhda , Kotova Svetlana , Hasanova Irina , Tserkovnikova Natalya , Lebedeva Viktoriya
Published: February 2022

The study considers the phenomenology of the professional crisis of the teacher personality in the context of the transition to online learning. Based on the analysis of the results of the theoretical and empirical research involving 170 teachers, it was established that the features of the professional crisis of the teacher personality are the transformation of the value-semantic sphere of the personality and the actualization of reflexive and anticipation processes. The results of the empirical research allowed for the first time to reveal the features of the professional crisis of the teacher in the context of the transition. The experimental group had the life efficiency indicator on the level 47.92 out of 100 points, while the control group – 69.59 points, which is not a much higher indicator. The results can become an empirical basis for the development of programs of psychological and pedagogical support for teachers experiencing professional crisis situations when implementing online learning programs.

 

Keywords: biographical reflection, content analysis, online learning, professional crisis, teacher personality
The level of efficiency of using digital resources for developing primary school students' linguodidactic potential
Authors: Makharova Gaukhar , Nurzhanova Sazhila , Adilbayeva Ulzhalgas , Dossanova Albina , Aimagambetova Malika
Published: February 2022

The aim of this research is to evaluate the effects of education given through digital resources on the language didactic potential of students with the views of teachers. 40 primary school teachers who teach 1st–4th-grade students in various provinces of Kazakhstan participated in the research. In the research, case study, which is one of the qualitative research methods, was used. The research data were collected through a semi-structured interview form prepared by the researcher in order to get the opinions of the teachers who voluntarily agreed to participate in the research. The research data were analysed by the content analysis technique. As a result of the research, it has been determined that teachers are prone to use technology and partially use digital resources in their lessons. However, teachers stated that they are more open to the use of digital resources if the opportunity is given. In addition, although most of the teachers state that the use of digital resources has no effect on increasing the workload of the teacher, some define it as a workload. With regard to the digital resources used in the course, teachers stated that it partially increased teacher success and that it had a positive effect on student success and student motivation. The research findings reveal that teachers need to receive supportive training on the use of digital resources in education.

Keywords; Digital resources, use of technology in education, linguodidactic potential of students, primary school teachers
Formation of singing skills of future music teachers through digital resources
Authors: Serikbol Shynybaev , Karylgash Kazhimova , Zhanna Akparova , Moldir Urazaliyeva , Zhumatay Taubaldieva
Published: February 2022

The purpose of this study is to investigate the determination of the formation of singing skills of future music teachers through digital resources. The quantitative research method was used in the study, and the research was conducted in the fall semester of 2021–2022. 376 volunteer music teachers who continue their studies in Kazakhstan participated in the study. In the study, 4 weeks of online training was provided to music teachers. In the study, the ‘digital music platform’ measurement tool developed by the researchers and compiled by experts in the field was used. The measurement tool was delivered and collected by the online method of music teachers. The analysis of the data was carried out using the SPSS programme; frequency analysis was carried out using the t-test; and the results obtained were added to the study accompanied by tables. According to the survey results, in live lessons, music teachers use the songs with the formation and this takes place where digital content is also very low. In the event of very frequent use, it was seen that by projecting courses in distance education systems the music rates are quite high.

 

Keywords: Music Teachers, Digital Content, Live Lesson, Teachers of the Future;
Introduction: Contribution, Causality, Context, and Contingency when Evaluating Inclusive Business Programmes
Authors:   Institute of Development Studies, Ton Giel , Vellema Sietze
Published: February 2022

The private sector has become an important partner in development interventions that aim to make market systems more favourable for smallholders and low-income consumers of food. How to evaluate these inclusive business programmes is the central theme of this IDS Bulletin. It presents real-world experiences of practitioners and academics using theory-based evaluation. This introductory article highlights the approaches and methods used to assess systemic change and provide learning for adaptive management. It acknowledges the limits to attributing outcomes to programmes alone and proposes a way to generalise about effectiveness where outcomes are highly contingent on a specific contextual embedding. The article explores the synergy of the iterative reflections on the theory of change, the analytical approach of realist evaluation, and the conceptualisation of changes in firms’ practices as emerging from behaviour systems where the motivations, opportunities, and capabilities of firms are not equally distributed.
La explotación de recursos líticos en el entorno geológico del sitio prehispánico de Sihó (Yucatán) a través del análisis fisicoquímico de los metates de caliza
Authors: Pujol Pizà Llorenç
Published: February 2022

Siho is an archaeological site located in the Northern Maya Lowlands, where a number of grinding tools have been documented, mostly metates made with local limestone that has petrological characteristics (physical and chemical) which may indicate a particular geological origin. The statistical treatment of data extracted by X-ray fluorescence allows us to discern limestone materials from different geological formations, based on the quantity of silicon (Si) and/or calcium (Ca) in the sample. This data shows a link between the limestone of the Sihó metates and the rocks from the geological formation known as Carrillo Puerto located in the Yucatan peninsula. Furthermore, the comparison by mean thin sections between geological and archaeological materials has been useful to characterise and identify lithic materials used to fabricate the metates. The complementarity between both archaeometrical techniques, together with ethnographic, historical and archaeological documentation, provide us with information that suggests an immediate exploitation of the limestone rocks used to make the metates and brings us closer to a better understanding of the quarrying strategies practiced by the ancient Mayans of Sihó.
Escolhas alimentares e sustentabilidade
Authors: Siloto Denise Aparecida Pereira , Leal Giuliana Franco , Schottz Vanessa
Published: February 2022

Neste artigo reflete-se sobre a relação entre as escolhas alimentares de consumidores e a sustentabilidade, a partir do estudo de caso de uma feira livre no município de Macaé (RJ). Usando-se observação participante e entrevistas com frequentadores da feira, busca-se identificar os motivos e interesses que orientam suas decisões de consumo, com especial atenção às questões ambientais. A pesquisa mostrou a busca de orgânicos na feira como fortemente associada à preocupação com a qualidade dos alimentos, mas nem sempre conectada com as dinâmicas que envolvem a produção de base familiar, como a luta pela terra e o acesso à água. As questões ambientais estão presentes nas escolhas dos consumidores, embora, nem sempre se traduzam numa conduta coerente com a busca da sustentabilidade.
O impacto ambiental da edição genética no Brasil
Authors: Nohama Norton , Silva Jefferson Soares da , Simão-Silva Daiane Priscila
Published: February 2022

O Brasil detém uma das maiores biodiversidades ambientais do mundo e ao mesmo tempo, quando se trata do consumo de biotecnologias, é o segundo país no uso de organismos geneticamente modificados. Este cenário denota um campo fecundo para a aplicação das promissoras tecnologias de edição genética na área ambiental e agropecuária. No entanto, aos benefícios oferecidos pelo uso da técnica, há a necessidade emergente de se elencar os riscos ambientais envolvidos, visando assegurar o seu gerenciamento adequado e a proteção ambiental em termos globais. Nesse contexto, de manipulação de organismos e sistemas vivos, a imprevisibilidade emerge como um dos fatores singularmente problemáticos. Apesar disso, os conflitos éticos que dela emergem podem ser pautados a partir de uma ética da responsabilidade, baseada em um dever primário de precaução sobre as perspectivas futuras possíveis. O presente artigo, a partir do referencial da bioética global, aborda tais imprevisibilidades e conflitos, considerando que o debate em curso sobre as mesmas inovações biotecnológicas para manipulação genética, requer não apenas ampliar o horizonte de análise sobre as questões ambientais, mas também aprofundar as reflexões que levem em consideração aspectos próprios das técnicas de manipulação do genoma em uso, especialmente no desafiante contexto brasileiro, detentor de tão grande biodiversidade.
Entrevista com Heloisa Soares de Moura Costa (IGC/UFMG)
Authors: Camargo Kelly Cristina de Moraes , Schmidt Augusto Frederico Junqueira , Anazawa Tathiane Mayumi , Monges Alma , Carmo Roberto Luiz do
Published: February 2022

A Revista Temáticas realizou uma entrevista exclusiva com a Dra. Heloisa Soares de Moura Costa, professora titular do Departamento de Geografia da Universidade Federal de Minas Gerais.
Single Nucleotide Polymorphism rs1800497 in Risperidone and Aripiprazole Therapy for Schizophrenia Patients
Authors: Widodo Benedictus Wicaksono , Saleh Mgs. M. Irsan , Theodorus Theodorus
Published: February 2022

Schizophrenia is a variable of psychopathologic syndrome involving cognition, emotion, perception, and other behavioral aspects. Therapies on schizophrenia is solely based on history of mental illnesses and mental status. Schizophrenia affecting 1.1 million persons globally in 2017; 70.8% of them happened in 25-55 years old. This study was conducted in mental hospital in Palembang, Indonesia. Blood samples was taken from clinically diagnosed schizophrenia patients (20 patients taking aripiprazole and 60 patients taking risperidone) under therapy. DNA was extracted using Chelex 100 method and digested using Taq1 enzyme. DNA was electrophoresized and visualized. CC allele was found in 10% of patients taking aripiprazole and 11.67% patients taking risperidone. CT allele was found in 70% patients taking aripiprazole and 76.67% patients taking risperidone. TT allele was found in 20% patients taking aripiprazole and 11.67% patients taking risperidone. ANKK1 Taq1A polymorphism in schizophrenia patients shows different therapeutic response with worse therapeutic response compared to patients with normal allele.
Characteristics Study and Total Flavonoids Quantification of Kareho Leaves (Callicarpa longifolia Lam)
Authors: Wathan Nashrul , Fadlilaturrahmah Fadlilaturrahmah , Arishandi Saufy , Firdaus Akhmad Rezeki
Published: February 2022

The Callicarpa longifolia Lam. known as ‘kareho’ is one of the plants used by several Dayak tribes for traditional medicine such as antiacne, swelling, wounds, diarrhea, diabetes, and lowering cholesterol levels. This study has obtained scientific data on the characteristics of dried leaves and determined the flavonoids levels of methanol extract of C. longifolia leaves. Characterization includes both qualitative and quantitative examination on the dried leaves of C. longifolia leaves, while the determination of total flavonoid content was determined by the aluminium chloride method and calculated as quercetin equivalent (QE). The results of characteristics observations obtained organoleptic in the form of powder, dark green, bitter taste and have a distinctive smell. Microscopic test of leaves had an actinositic stomata type, ethanol soluble extract content of 17.50 ± 0.10% and water soluble extract content of 16.53 ± 0.37%. Drying loss 8.16 ± 0.25%, total ash content of 5.52 ± 0.06%, and acid insoluble ash content of 0.07 ± 0.01%. The results of phytochemical screening confirmed the presence of saponins, flavonoids, steroids, tannins, glycosides, and phenols. TLC observasions using 254 nm UV light obtained 6 spots and 7 spots appearance on sulphuric acid. It has total flavonoid levels obtained at 7.995 ± 0.050% w/w QE.
TOURIST ACCOMMODATION IN HOUSEHOLDS - PERCEPTION OF SERVICE QUALITY
Authors: Vrtodušić Hrgović Ana-Marija , Brito Elisabeth , Petaković Ema
Published: February 2022

Purpose – The research focuses on analysing the service quality in tourist accommodation in households. The aim of this paper is to determine whether there are statistically significant differences in the perception of quality service (technical and functional quality aspect), with emphasis on quality improvement. Methodology – The research was based on a structured questionnaire, which was carried out during the summer months of 2020, on a sample of 168 tourists who stayed in tourist accommodation in households. According to the type of data obtained, statistical differences between multiple groups are examined using nonparametric Kruskal-Wallis H Test in IBM SPSS Statistic software. Findings – The results indicate that there are statistically significant differences in the perception of service quality with regard to socio-demographic characteristics of the respondents. Foreign guests visiting Croatia and staying in tourist accommodation in households rate the quality of service at a higher rate compared to domestic guests. Regarding the differences based on qualification levels and age, individuals with university degrees, and those in the age group 60-77 tend to give statistically significantly higher ratings to quality elements. Contribution – The scientific contribution of the research is seen in widening the knowledge on service quality as well as the development of a measuring instrument for measuring service quality taking in to account tourist accommodation in households. Its practical contribution can be seen in the comparison of service quality dimensions, taking into account socio - demographic characteristics of respondents, based on which improvement of quality can be made in this segment of accommodation offer.
Her Dream Home : Domesticity and Gender in Advertising in Arts & Architecture = El Hogar de sus Sueños: domesticidad y género en la Publicidad de Arts & Architecture
Authors: Díez Martínez Daniel
Published: February 2022

AbstractIn the United States, with the end of World War II, a cultural and territorial model based on the suburban lifestyle took root. Women had taken an active role during the conflict, but postwar American society returned them to the background, restricting them to the care of family and home. The domestic space became again a distinctly female ecosystem. From a gender perspective this article explores how the discourse on housewives and domesticity was expressed in the specialized press, particularly in advertisements published in Arts & Architecture. It tries to show how advertising contributed to the association drawn between women and the domestic sphere, and in particular to the idea of the kitchen as an inherently feminine space. Women were mostly assigned an ornamental role as passive consumers, but occasionally they were portrayed as experts capable of instructing architects on how to design the home.ResumenEl final de la Segunda Guerra Mundial consolidó en Estados Unidos un modelo cultural y territorial basado en el estilo de vida suburbano. Aunque las mujeres habían tenido un papel activo duran­te el conflicto, la sociedad estadounidense de posguerra las relegó a una posición secundaria limitada a las tareas de cuidado familiar y del hogar, por lo que el espacio doméstico se convirtió en un ecosistema netamente femenino. El objetivo de este artículo consiste en estudiar cómo se estructuró este discurso en la prensa especializada utilizando los anuncios de la revista Arts & Architecture. Se muestra cómo la publicidad contribuyó a la asociación entre la mujer y el ámbito doméstico, y en particular a definir la cocina como un espacio inherentemente femenino. A las mujeres se les asignó principalmente un papel ornamental como consumidoras pasivas, aunque ocasionalmente también aparecían como expertas capaces de instruir a los arquitectos sobre cómo diseñar una casa.
Insights into tertiary lymphoid structures in the solid tumor microenvironment: anti-tumor mechanism, functional regulation, and immunotherapeutic strategies
Authors: Zhao Hua , Wang Hao , Zhou Qiuru , Ren Xiubao
Published: February 2022

Tertiary lymphoid structures (TLSs) are ectopic immune cell aggregations that develop in peripheral tissues in response to a wide range of chronic inflammatory conditions, including infection, autoimmune disease, and cancer. In the tumor microenvironment (TME), the structures of TLSs, including B-cell- and T-cell-enriched areas indicate that the TLSs might be the local site during the initiation and maintenance of humoral and cellular immune responses against cancers. Numerous studies have evaluated the expression of TLSs in different cancer patients and their association with prognoses of cancer patients. It was shown that welldeveloped TLSs characterized by mature B cells synthesized tumor specific antibodies, which were considered as specific markers for a good prognosis. However, there are still some immunosuppressive factors existing in the TLSs that may affect anti-tumor responses. These factors include dysfunctional B cells, regulatory T cells, and T follicular regulatory cells. The complexity and heterogeneity of the TLS composition may affect the function and activity of TLSs; it is therefore essential to fully understand the function and influencing factors in TLSs. It has been reported that checkpoint inhibitors and vaccines are currently being developed to reprogram the TME by establishing mature TLSs to improve cancer immunotherapies. In this review, we focused on recent advances in TLSs in human solid tumors, including structural characteristics and classes, antitumor mechanisms, immunosuppressive factors, and TLSbased therapeutic approaches.
The Endemic Vascular Flora of Sardinia: a Dynamic Checklist with an Overview of Biogeography and Conservation Status
Authors: Fois Mauro , Farris Emmanuele , Calvia Giacomo , Campus Giuliano , Fenu Giuseppe , Porceddu Marco , Bacchetta Gianluigi
Published: February 2022

The vascular flora of Sardinia has been investigated for more than 250 years, with particular attention to the endemic component, due to their phylogeographic and conservation interest. However, continuous changes in the floristic composition through natural processes, anthropogenic drivers or modified taxonomical attributions require constant updating. We checked all available literature, web sources, field and unpublished data from authors and acknowledged external experts to compile an updated checklist of vascular plants endemic to Sardinia. Life and chorological forms, and the conservation status of the updated taxa list were reported. Sardinia hosts 340 taxa (15% of the total native flora) endemic to the Tyrrhenian islands and other limited continental territories; 195 of these are exclusive to Sardinia. Asteraceae (50 taxa) and Plumbaginaceae (42 taxa) are the most representative families, while the most frequent life forms are hemicryptophytes (118 taxa) and chamaephytes (105 taxa). The global conservation status, available for 200 taxa, indicates that most endemics are under the ‘Critically Endangered’ (25 taxa), ‘Endangered’ (31 taxa) or ‘Least Concern’ (90 taxa) IUCN categories. This research provides an updated basis for future biosystematics, taxonomic, biogeographical and ecological studies, and for supporting more integrated and efficient policy tools.
What Should I Notice? Using Alogithmic Information Theory to Evaluate the Memorability of Events in Smart Homes
Authors: Houzé Étienne , Dessalles Jean-Louis , Diaconescu Ada , Menga David
Published: February 2022

With the increasing number of connected devices, complex systems such as smart homes record a multitude of events of various types, magnitude and characteristics. Current systems struggle to identify which events can be considered more memorable than others. In contrast, human are able to quickly categorize some events as being more “memorable” than others. They do so without relying on knowledge of the system’s inner working or large previous datasets. Having this ability would allow the system to: i) identify and summarize a situation to the user by presenting only memorable events; ii) suggest the most memorable events as possible hypotheses in an abductive inference process. Our proposal is to use Algorithmic Information Theory to define a “memorability” score by retrieving events using predicative filters. We use smart-home examples to illustrate how our theoretical approach can be implemented in practice.
The Turmell-Meter: A Device for Ankle Joint Axis Estimation Appliyng Product of Exponentials
Authors: Agudelo Óscar , Valera Ángel , Vargas-Riaño Julio
Published: February 2022

The human ankle is a complex joint, most commonly represented as talocrural and subtalar axes. It is difficult to locate and take in vivo measurements of the ankle joint. There are no instruments for patients lying on a bed or the floor; that can be used in outdoor or remote sites. We have developed a "Turmell-meter" to address these issues. We started with the study of ankle anatomy and anthropometry, then we used the product of exponentials’ formula to visualize the movements. Furthermore, we built a prototype using human proportions and statistics. For pose estimation, we used a trilateration method by applying tetrahedral geometry. Additionally, we computed the axis direction by fitting 3D circles, plotting the manifold and chart as an ankle joint model. We presented the results of simulations, a prototype comprising 45 parts, specifically designed draw-wire sensors, and electronics. Finally, we tested the device by capturing positions and fitting them into the bi-axial ankle model as a Riemannian manifold. The Turmell-meter is intended to be a hardware platform for human ankle joint axis estimation, it is adjustable and has an easy setup. The proposed model has the properties of a chart in a geometric manifold, we provided the details
Online Anomaly Detection for Smartphone-Based Multivariate Behavioral Time Series Data
Authors: Liu Gang , Onnela Jukka-Pekka
Published: February 2022

To detect aberrant human behaviors from large volume of passive data collected by smartphones in real time, we propose an online anomaly detection method using Hotelling’s T-squared test. The test statistic is a weighted average, with more weight on the between-individual component when there are little data available for the individual and more weight on the within-individual component when the data are adequate. The algorithm takes only O(1) run time in each update and the required memory usage is fixed after a pre-specified number of updates. The performance of the proposed method, in terms of accuracy, sensitivity and specificity, is consistently better than or equal to the offline method that it builds upon depending on the sample size of the individual data.
Machine Learning and Internet of Medical Things for Handling COVID-19: Meta-Analysis
Authors: Band Shahab , Ardabili Sina , Yarahmadi Atefeh , Pahlevanzadeh Bahareh , Kausar Kiani Adiqa , Beheshti Amin , Alinejad Rokny Hamid , Dehzangi Iman , Mosavi Amir
Published: February 2022

Early diagnosis, prioritization, screening, clustering and tracking of COVID-19 patients, and production of drugs and vaccines are some of the applications that have made it necessary to use a new style of technology to involve, to manage and deal with this epidemic. Strategies backed by artificial intelligence (AI) and the Internet of Things (IoT) have been undeniable to understand how the virus works and try to prevent it from spreading. Accordingly, the main aim of this survey article is to highlight the methods of ML, IoT and the integration of IoT and ML-based techniques in the applications related to COVID-19 from the diagnosis of the disease to the prediction of its outbreak. According to the main findings, IoT provided a prompt and efficient approach of following the disease spread. Most of the studies developed by ML-based techniques for handling COVID-19 based dataset provided performance criteria. The most popular performance criteria, is related to accuracy factor. It can be employed for comparing the ML-based methods with different datasets. According to the results, CNN with SVM classifier, Genetic CNN and pre-trained CNN followed by ResNet, provided highest accuracy values. On the other hand, the lowest accuracy was related to single CNN followed by XGboost and KNN methods.
Stand for Biomimetic Swimming Fins Fatigue Testing
Authors: Kiciński Radosław , Kruszkowska Ewa Olewnik , Szturomski Bogdan , Jurczak Wojciech
Published: February 2022

TThe aim of the work is to present a newly developed stand and methodology of accelerated tests of fatigue strength of flexible propellers and fins. The paper presents the design and concepts of the measuring elements used in the research. Test methodology and water stressing were devel-oped. The mechanical properties of the following materials were presented: Arnitel EL-550 and QUEO 8230 with the addition of PP / EVA 50/50 (polypropylene / ethylene-vinyl acetate) - in the proportion of 70/30 (QUEO 8230 / additive). The constructed test stand and a new method of fa-tigue testing of biomimetic fins made it possible to determine the number of fin movement cy-cles under a given load, which may facilitate the determination of a warranty for a newly intro-duced product. The current consumption by the fin drive and video monitoring allowed for the selection of the range of the number of movement cycles and the determination of the moment of fatigue cracks until the fin structure loses its capacity. During the analysis, the test results showed that the fins made of Arnitel EL-550 did not show changes in the measured values of the current and the force generated by the fin. For a fin made of QUEO 8230, at 35,000 cycles, there is a decrease in the current and force consumed, which indicates the initiation of fatigue damage to the fin. The performed tests can be the basis for the development of standards for the fatigue strength of flexible propellers.
Fabrication of Color Glass With High Light Transmittance by Pearlescent Pigment and Optical Adhesive
Authors: Ahn Hyeon-Sik , Gasonoo Akpeko , Lim Seong-Min , Lee Jae-Hyun , Choi Yoonseuk
Published: February 2022

In this study, we propose a solution process for realizing color glass for building integrated pho-tovoltaic (BIPV) systems by spin coating a color solution composed of a pearlescent pigment mixed in a norland optical adhesive (NOA) matrix. Color solutions are made from mixing pearlescent pigments in NOA63. Compared to a physical vapor deposition process, color coatings are achieved by spin coating in a relatively simple and inexpensive process at room temperature. The optical properties can be easily controlled by adjusting the spin coating speed and the concentra-tion of the pearlescent pigments. The produced color glasses achieved a high transmittance of 85% or more in the visible wavelength range, except the wavelength spectrum exhibiting the maxi-mum reflectance. In addition, we propose a one-step lamination process of color glass on a solar cell by leveraging on the adhesive property of the NOA matrix. This eliminates the cost and pro-cess of additional ethylene vinyl acetate (EVA) layer or other materials used in the conventional lamination process. The color glass produced through this study has stability that does not change its properties over time. Therefore, it is expected to be applied to the BIPV solar module market where aesthetics and energy efficiency are required.
The Effect of Avocado Seed Extract (Persea americana) on Carbide Induced Hepatoxicity in Adult Wistar Rats
Authors: Okpala Victoria Nneoma , Edet Mark Matthew , Ezejindu Damian Nnabuihe
Published: February 2022

Context: Persea Americana is reported to have medicinal value. Calcium Carbide (CaC2), a fruit-ripening agent, has been shown to be toxic to body organs. Objective: To determine the effect of avocado seed extract (ASE) on CaC2-induced hepatotoxicity in rats. Methodology: Four experimental groups, each of 5 adult wistar rats were fed respectively with normal diets (group A); 250mg/kg ASE (group B); 100mg/kg CaC2 (group C); combination of 100mg/kg CaC2 and 250mg/kg ASE – group D. Changes in the rats’ behaviours, body weights, and liver function were assessed over 21 days. Data were analyzed using SPSS. The cumulated rat weights, rat liver weights and serum liver enzyme levels for groups B, C, and D rats were compared to group A. Results: Abnormal behavior was most observed in group C rats. Rats in group A showed a significant increase in weight before and three weeks following administration of feeds while rats in groups B, C, and D showed significant decrease in weight – more marked in group C rats. Only the mean liver weights of rats in group C showed significant decrease compared to that in group A, p = 0.001. Similarly, only the cumulated liver enzyme levels of rats in group C demonstrated significant increase when compared to group A rats - indicating hepatotoxicity. Conclusion In this study, hepatotoxicity occurred in CaC2-administered rats. However, the combination of CaC2 and ASE showed no liver toxicity indicating a mitigating effect of ASE to CaC2-induced hepatotoxicity.
Analysis of E-Advertising on Sales
Authors: Rohmawati Tatik , Luckyardi Senny
Published: February 2022

The purpose of this research is to analyse the increase in product sales using social media advertising. The research was conducted using literature study method and questionnaires that distributed to sellers who used social media advertising in marketing their products. The results show that selling products on social media using advertisements can generate more sales and cunsomers. With social media advertising, sellers can choose the type of potential customers according to the product being sold. The sellers can determine the type of prospective customer based on thier age, residence, and/or hobbies to it easier for the seller to divert the sale of their product. Therefore, social media advertising helps sellers who market their products to generate more sales.
Covid-19 Pandemic and Welfare of Fishermen Kamal Muara
Authors: Afriana Wendra , Abdulkadir Amanah , Azis Harry
Published: February 2022

This paper aims to find out the right and fast strategy in anticipating the decline in the welfare of fishermen Kamal Muara during the Covid-19 pandemic. The research used SAST, AHP, and ISM analysis methods. Based on the results of ISM processing, it shows that the most appropriate and quick strategy is to provide subsidies for fishermen's losses due to large-scale social restrictions (PSBB). Second, providing training programs for processing derivative products and training on sales digitization. Third, with digital marketing training to optimize the marketing of their fish catch while ensuring the safety of anglers at work. The government's role, in this case, is not only in budget allocation but also fosters and assists so that anglers can be adaptive to technology in every fishing activity.
A Rasch Analysis on Tourism Business in Covid-19 Era: The Attactiveness of Taman Mini Indonesia Indah (TMII) Jakarta
Authors: Lusia Erma , Herlina Maria Grace
Published: February 2022

The SARS-CoV-2 pandemic impacts health, the economy, and the environment (also known as COVID19). It's no secret that tourism has been hit particularly hard during the Covid-19 era. Nevertheless, many people continue to search for a tourist destination despite the covid-19 health protocol. Individuals tend to stay home during an outbreak, and large families with young children travel shorter distances than other tourist groups. Local visitors continue to be interested in TMII as a domestic tourism destination as 74 percent of visitors want to visit TMII. Analysis of TMII's amenities and ancillary services using the Rasch Model revealed the most attractive destination attributes. However, when it comes to transportation options, they are by far the least appealing.
Acute Quadriceps Tendon Rupture: Presentation, Diagnosis, and Management
Authors: Arnold Evan P. , Sedgewick Justin A. , Wortman Ryan J. , Stamm Michaela A. , Mulcahey Mary K.
Published: February 2022

» The incidence of quadriceps tendon rupture is estimated to be 1.37 cases per 100,000 people/year, with a predilection for these injuries in patients who are ≥40 years of age.

» Quadriceps tendon ruptures are more likely to occur in the presence of preexisting comorbidities such as rheumatoid arthritis, systemic lupus erythematosus, gout, chronic kidney disease, secondary hyperparathyroidism, diabetes mellitus, and peripheral vascular disease. The most common mechanism of injury is a simple fall.

» Magnetic resonance imaging is the gold-standard test for diagnosing quadriceps tendon ruptures, with a reported sensitivity, specificity, and positive predictive value of 1.0.

» Complete tears require prompt surgical intervention; the most common technique is transosseous sutures passed through longitudinal patellar drill holes. Suture anchors have been proposed as an alternative method; they have shown superior biomechanical results in cadaveric models.

» Early functional mobilization with full weight-bearing and progressive range-of-motion exercises is recommended for rehabilitation following injury.
An Adaptive Design To Screen, Treat And Retain People With Opioid Use Disorders Who Use Methamphetamine In Methadone Clinics (STAR-OM) Study Protocol of A Clinical Trial
Authors: Minh Giang Le , Thu Trang Nguyen , Bich Diep Nguyen , Dieu Thuy Dao Thi , Thanh Thuy Dinh , Dinh Hoe Han , Hai Van Hoang Thi , Thanh Truc Thai , Nguyen Hoa Hong , Ly Lai Nguyen , Dan Linh Pham Thi , Tuong Vi Vu Thi , Reback Cathy J. , Leibowitz Arleen , Li Li , Lin Chunqing , Li Michael , Van Dung Do , Shoptaw Steve
Published: February 2022

Background: Methamphetamine use could jeopardize the current efforts to address opioid use disorder and HIV infection. Evidence-based behavioral interventions (EBI) are effective in reducing methamphetamine use. However, evidence on optimal combinations of EBI is limited. This protocol presents a Type-1 effectiveness-implementation hybrid design to evaluate the effectiveness, cost-effectiveness of adaptive methamphetamine use interventions and their implementation barriers in Vietnam. Method: Design: Participants will be first randomized into two frontline interventions for 12 weeks. They will then be placed or randomized to three adaptive strategies for another 12 weeks. An economic evaluation and an ethnographic evaluation will be conducted alongside the interventions. Participants: We will recruit 600 participants in 20 methadone clinics. Eligibility criteria: 1) age 16+, 2) Alcohol, Smoking and Substance Involvement Screening Test (ASSIST) scores 10 or more for methamphetamine use or confirmed methamphetamine use with urine drug screening; 3) willing to provide three pieces of contact information; 4) having a cell phone.Outcomes: Outcomes are measured at 13-, 26- and 49-week and throughout the interventions. Primary outcomes include: (1) increase in HIV viral suppression; (2) reduction in HIV risk behaviors; and (3) reduction in methamphetamine use. COVID-19 response: We developed a response plan for interruptions caused by COVID-19 lockdowns to ensure data quality and intervention fidelity. Discussion: This study will provide important evidence for scale-up of EBIs for methamphetamine use among methadone patients in limited-resource settings. As the EBIs will be delivered by methadone providers, they can be readily implemented if the trial demonstrates effectiveness and cost-effectiveness. Trial registration: NCT04706624. Registered 13 January 2021. https://clinicaltrials.gov/ct2/show/NCT04706624
Virtual Reality Experience During Labour (VIREL); a Qualitative Study
Authors: Musters Anne-Claire , Vandevenne Ann-Sofie , Franx Arie , Wassen Martine MLH
Published: February 2022

Background There is increasing evidence that virtual reality (VR) is effective in the reduction of labour pain. The implementation of alternative methods like VR to reduce labour pain can contribute to reduce the request of pharmacological pain management methods and associated side effects. The aim of this study is to examine women’s experiences, preferences and satisfaction in regard to the use of VR during labour. Methods A qualitative interview study conducted in a non-university teaching hospital in The Netherlands. Two VR applications, respectively a guided meditation (VR1) and an interactive game (VR2) were tested in eligible women with a singleton pregnancy, scheduled for induction of labour. For the primary outcome, patients’ VR experience and application preference were examined using a post-intervention questionnaire and a semi-structured interview. Labour pain before and directly after VR was evaluated using the NRS score.Results 24 women, of whom fourteen were nulliparous and ten multiparous, were included and 12 of these women participated in semi-structured interviews. Three themes were identified after data analysis: “The VR experience”, “Pain reduction”, and “Usability of the VR application”. All patients were highly satisfied with VR use during labour and reported pain reduction during VR. VR1 was preferred above VR 2 by 17 (71%) women. Both VR1 and VR2 caused a significant decrease in mean NRS scores comparing pain pre-VR use to pain during VR use, of respectively 1·81 (VR1) vs. 1·28 (VR2).Conclusion All women were highly satisfied with VR use during labour, preferred guided meditation and experienced less pain. These results can contribute to the development of a potential promising new non-pharmacological tool to reduce labour pain.
Neurocognitive Screening in Patients Following SARS-CoV-2 Infection: Tools for Triage
Authors: Blackmon Karen , Day Gregory S. , Powers Harry Ross , Bosch Wendelyn , Prabhakaran Divya , Woolston Dixie , Pedraza Otto
Published: February 2022

Background and purpose Cognitive complaints are common in patients recovering from Coronavirus Disease 2019 (COVID-19), yet their etiology is often unclear. We assess factors that contribute to cognitive impairment in ambulatory versus hospitalized patients during the sub-acute stage of recovery. Methods Participants were prospectively recruited from a hospital-wide registry. All patients tested positive for SARS-CoV-2 infection using a real-time reverse transcriptase polymerasechain-reaction assay. Patients ≤ 18 years-of-age and those with a pre-existing major neurocognitive disorder were excluded. Participants completed an extensive neuropsychological questionnaire and a computerized cognitive screen via remote telemedicine platform. Rates of subjective and objective neuropsychological impairment were compared between the ambulatory and hospitalized groups. Factors associated with impairment were explored separately within each group. Results A total of 102 patients (76 ambulatory, 26 hospitalized) completed the symptom inventory and neurocognitive tests 24 ± 22 days following laboratory confirmation of SARSCoV-2 infection. Hospitalized and ambulatory patients self-reported high rates of cognitive impairment (27-40%), without differences between the groups. However, hospitalized patients showed higher rates of objective impairment in visual memory (30% vs. 4%; p=0.001) and psychomotor speed (41% vs. 15%; p=0.008). Objective cognitive test performance was associated with anxiety, depression, fatigue, and pain in the ambulatory but not the hospitalized group. Conclusions Focal cognitive deficits are more common in hospitalized than ambulatory patients. Cognitive performance is associated with neuropsychiatric symptoms in ambulatory but not hospitalized patients. Objective neurocognitive measures can provide essential information to inform neurologic triage and should be included as endpoints in clinical trials.
Bacteroidetes and Firmicutes Drive Differing Microbial Diversity and Community Composition Between Micro-environments in the Bovine Rumen
Authors: Pinnell Lee , Reyes Arquimides , Wolfe Cory , Weinroth Maggie , Metcalf Jessica , Delmore Robert , Belk Keith , Morley Paul , Engle Terry
Published: February 2022

Ruminants are a critical human food source and are a potentially important source of global methane emissions. Because of their unique digestive physiology, ruminants rely upon a symbiotic relationship with complex and rich microbial communities in the foregut to allow digestion of complex carbohydrates. This study used 16S rRNA gene sequencing to investigate the composition of microbial communities of three rumen micro-environments (free fluid, the fibrous pack, and the rumen mucosa) from cattle fed identical diets. While a phylogenetic core including the most abundant and most common ruminal taxa (members of Bacteroidetes and Firmicutes) existed across micro-environments, their abundances differed significantly, and specific lineages were discriminant of individual micro-environments. Firmicutes, and specifically Ruminococcaceae, Lachnospiraceae, and Clostridium were discriminant of fluid communities, while Bacteroidales and Desulfovibrio were discriminant of mucosa-associated communities. A set of four more diverse lineages were discriminant of pack-associated communities that included Paraprevotellaceae, Succinivibrionaceae, RFP12 (Verrucomicrobia), and Treponema. Our findings indicate that different ecological niches within each micro-environment have resulted in significantly different microbial communities and provide baseline values for the diversity and community structure of microbial communities from rumen fluid, pack, and mucosa that can contextualize the influence of environmental factors such as diet.
Quantitative Study on the Structure-bioavailability Relationship of Dissolved Organic Nitrogen in Wastewater Treatment Plant Effluent
Authors: Yan Cihang , Wei Zhiyu , Liu Jiayin , Chen Jie , Fan Lu
Published: February 2022

This study systematically investigated the relationship between the structure properties and biological characteristics of DON in the effluents from municipal wastewater treatment plants. Ultrafiltration, FTIR spectroscopy, UV spectroscopy and EEM fluorescence spectroscopy were used to characterize the structure of organic matters in the effluent samples, and the bioavailability of DON was determined by algal/bacterial based bioassay. The quantitatively analysis of EEM spectra conducted by fluorescence regional integration method showed that the organic portion of all samples were mainly consistent with fulvic acid and protein. Combined with the bioassay results, a positive correlation between the DON bioavailability and the protein content (sum of region I and region II) (r=0.80, P＜0.02) and soluble microbial byproduct-like materials (region IV) (r=0.76, P＜0.03) were observed. Nevertheless, the humic substances content represented by the region III and V would negatively affect the DON bioavailability. High humification degree (high HIX value) (r=-0.77, P＜0.03) was related to low bioavailability. Furthermore, according to UV spectroscopy results, strong aromaticity (high UV254 values) (r=-0.78, P＜0.03) suggested low DON bioavailability. The ultrafiltration experiment showed that the low molecular weight DON (＜3kDa) accounted for 30-73% of the total DON, and no notable relationship was observed for DON molecular weight and its bioavailability.
Reviewing the Implementation of Maternal, Neonatal, and Child Health Services during the COVID-19 Pandemic in Indonesia
Authors: Saputri Nurmala Selly , Dewi Rika Kumala , Anbarani Maudita Dwi , Toyamah Nina
Published: February 2022

BackgroundThe COVID-19 pandemic has challenged the resilience of Maternal, Neonatal, and Child Health (MNCH) care in Indonesia. Mobility restriction policy and obligatory preventive measures practices could influence the service implementation. Previous literature suggested that communicable diseases outbreak brought fear and mistrust to the health system which resulted in the decrease of service coverage during emergency situations. As one of the world’s worst-hit COVID-19 countries, Indonesia faces considerable challenges in maintaining health services, including MNCH care. This study investigated multi-level factors which become barriers to the implementation of MNCH care during the COVID-19 pandemic in Indonesia.MethodQualitative case study was conducted in three Kabupaten (districts), namely Sidoarjo, Gowa, and Manggarai Barat. The selection of these areas was based on the high COVID-19 cases and different achievements in MNCH indicators’ coverages. Individual in-depth interviews were conducted with 133 people involved in MNCH services, such as women as the main users of the services, health workers, cadres, village representatives, as well as staff from local district health offices. Data were analyzed using the Socio-Ecological Model (SEM) Framework and constant comparative techniques to triangulate information among informants. ResultA total of 133 people participated in the study, of which 67% were women who were pregnant, giving birth, or having children aged under-5 during the COVID-19 pandemic. The factors that affect the utilization of MNCH services were categorized in five socio-ecological levels of analysis, namely individual factors (fear of COVID-19 contraction and awareness of the importance of MNCH services); interpersonal factors (unsupportive extended family and financial barriers); community-based factors (local norms and beliefs, limited transportation services, and geographical barriers), organizational factors (unequal distribution of health resources, ineffective implementation of preventive measures in the health facility, and impractical innovation of services approach), and policy (rapid development of guidelines and ‘one size fits all’ policy issues). ConclusionsFear of COVID-19 contraction and persistent barriers from multi-faceted factors had hindered the effective implementation of MNCH care during the COVID-19 pandemic in Indonesia. The Government of Indonesia, along with local governments, are required to develop specific solutions based on the capacity of health resources as well as interactive and multilevel factors which inhibit women’s decision and practice to seek MNCH care in a volatile situation.