bluuebunny/crossref_metadata_2025 huggingface dataset:
Em cena, A Barraca: teatro, música e experimentações artísticas pós-Revolução dos Cravos
Authors: Paranhos Kátia
Published: December 2024

Depois do 25 de Abril de 1974 – data que remete à Revolução dos Cravos ou Revolução de Abril, que depôs o regime ditatorial do “Estado Novo” português –, uma movimentação profunda, marcada pela convergência de teatro de tradição brechtiana, neorrealista e experimentalismo, foi ganhando espaço e liberdade para constituir uma cena permeável a formas novas e a processos mais diferenciados de expressão. Em sintonia com esse processo criativo, proponho-me a examinar a importância dos espetáculos musicais do grupo A Barraca (dirigido por Maria do Céu Guerra e Hélder Costa), levando em consideração como a música se integra ao texto tal como um contraponto dramatúrgico e, via de regra, interage com a cena, resume-a ou a explica, fecha uma sequência, apresenta os personagens ou age como elemento de ligação entre as cenas. Deparamo-nos com situações em estilo de reportagem, cenários móveis, sons e falas entre atores e a plateia. Em outras palavras, pode-se perceber uma reavaliação do processo de produção dramática, da narrativa, da linguagem cênica e da relação com o espectador. Com base nessa experiência, procurarei realçar os sentidos da proposta de A Barraca pós-Revolução dos Cravos, assentada no binômio história e cultura, num redimensionamento do teatro popular cujo poder comunicativo evidencia os sentidos de uma invenção teatral engajada, poética e sonora.
IMPROVING THE EFFICIENCY OF ENERGY COMPANIES BY OPTIMISING THE DISTRIBUTION OF COSTS FOR MAINTENANCE AND REPAIR OF ELECTRICAL EQUIPMENT
Authors: Bardyk Yevhen , Zakliuka Ihor
Published: December 2024

At present, there is a high emergencies probability in the electric power system as an electrical equipment failures result caused primarily by the objectively existing ageing and its service life significant exhaustion. Emergencies arising from electrical equipment failures lead to the dynamic stability violation of power systems and power system load nodes by voltage, cascading accidents and, as a result, technological processes disruption of consumer enterprises, which is accompanied by significant losses. One of the ways to prevent sudden failures or minimise the risk of their occurrence is to ensure rational and efficient operation management and reduce the operating equipment cost without risking a decrease in the power system reliability.
To solve the optimal distribution problems of power company operating costs, taking into account the objectively existing limiting factors, a generalised balance sheet model of cost allocation by electrical equipment groups and units is proposed, which is a total costs function of an operating factors number.
Mathematical models for calculating the electrical equipment share participation coefficients in the costs formation for its repair and maintenance for each of the identified factors have been obtained. A linguistic mathematical model for determining generalised estimates of the electrical equipment units and groups significance degree in the repair and maintenance costs distribution formation, taking into account the main operational factors, has been proposed.
An algorithm and software for modelling the modes of the electric power system with an electrical connections scheme of electric networks with a 35-330 kV voltage have been developed to assess the operation risk index and power company repair and maintenance costs distribution. The estimated power company repair and maintenance costs distribution according to the current technical equipment characteristics and power system subsystem modes was performed.
ANALYSIS OF THE RESULTS OF THE IMPLEMENTATION OF THE BAN ON THE SIMULTANEOUS INTRODUCTION OF POSITIVE REACTIVITY IN TWO OR MORE WAYS
Authors: Bibik Tymofii , Ostapenko Ivan , Kuzmenko Volodymyr
Published: December 2024

The main reason for the prohibition of simultaneous injection of positive reactivity in two or more ways is the requirements of the nuclear safety rules for reactor installations. The introduction of positive reactivity by the means of influence on reactivity, provided for by the technical design of the reactor installation, should be excluded, if the emergency protection working bodies are not brought to the working position. Technical measures should exclude the possibility of introducing positive reactivity simultaneously by two or more provided means of influencing reactivity, as well as introducing positive reactivity by means of influencing reactivity during fuel loading and unloading. The rate of increase in reactivity by means of influencing the reactivity should not exceed 0.07 βef/s. For the working bodies of the control and protection system with an efficiency of more than 0.7 βef, the introduction of positive reactivity should be stepwise, with a step weight of no more than 0.3 βef (provided by technical measures). In the technical design of the RU, the size of the step, the pause between steps and the rate of increase in reactivity should be indicated.
The consequence of introducing positive reactivity in two or more ways is a possible violation of the conditions for normal operation of nuclear power plants due to an uncontrolled increase in the neutron flux in operating and emergency modes of the reactor. The installed second-type warning protection, which is supposed to solve this problem, has shortcomings in its operation that lead to a clear violation of the current prohibition on the simultaneous introduction of positive reactivity in two or more ways. On the basis of the conducted research, the existing error in the operation of the PP-2 was identified and analyzed. To avoid the problem with the simultaneous introduction of positive reactivity in two or more ways, it is proposed to modernize the system of PP-2 with its further operation on reactivity indicators.
CHANGES IN THE GLOBAL ENERGY SECTOR CAUSED BY RUSSIA'S WAR AGAINST UKRAINE
Authors: Tretiakova Larisa , Pobigaylo Vitalii , Usatii E.
Published: December 2024

Problems. The Russian invasion of Ukraine, Russia's refusal to accept the planned volumes of natural gas to the countries of the European Union caused a global energy and financial crisis, and changed the movement towards the development of renewable energy. the transition to sustainable and clean energy sources has become problematic for many countries.
Objective. General review and analytical analysis of trends in the development of energy consumption and the introduction of renewable sources in electric power systems in 2017-2023 using the results of research International Energy Agency (IEA), listed in World Energy Outlook (WEO) [1-6].
Methodology of implementation Trends in the development of the world system of renewable power plants to ensure climate neutrality, zero emissions, and a clean ecological environment have been analyzed for the study of the topic article. The study of changes and ways to limit the negative consequences of hostilities in Europe and the Middle East was carried out according to the long-term plans of the IEA.
Results. An overview of changes in the structure of energy resources in the world energy balance is presented. It is shown that the energy crisis has led to a sharp increase in the production of fossil fuels, primarily coal and oil. The construction of new capacities for the production of 250 billion tons of liquefied gas has begun. in order to stabilize fuel prices and reduce the price of electricity. Statistical and forecast information on the structure of the world energy balance and annual electricity production by types of generation is provided.
The environmental negative consequences registered for the last three years are considered: increased CO2 emissions; air pollution with fine dust; pollution of soils and water horizons; changes in climatic indicators. The problems that have arisen for the implementation of new projects for the construction of renewable sources, the development of electric power infrastructure, security and reliability of power supply are analyzed. An analysis of the proposed measures under several scenarios to increase the production and use of solar, wind and nuclear energy, reduce dependence on traditional energy sources and the prospect of zero carbon dioxide emissions by 2030 is carried out.
Conclusions. Actions aimed at reducing energy consumption, projected reduction in fuel prices, planned restarts of nuclear power and further implementation of renewable power plants – these are the proposed measures that make it possible to solve the problems that have arisen around the world. Confidence in meeting the tasks is confirmed by 83 countries and the European Union to meet their commitments to achieve zero carbon dioxide emissions on time and in full. Learning from the experience and directions of development of the world energy sector will create an opportunity for the rapid restoration of the energy structure in Ukraine in the post-war period.
The Life of Science and Thought in the Period of Sultan Mehmet the Conqueror
Authors: Özkan Selim Hilmi
Published: December 2024

The Ottoman Empire was one of the principalities established in Anatolia after the Mongol invasion. The principality embarked on a conquest movement in the border region to make room for Turkmen from the east. After becoming politically more potent, this process fought with both Byzantium and Anatolian principalities and gave importance to science, art, and education. As a result, it attracted the attention of scholars in the region in a short time. Because the Seljuks had left a great scientific heritage, it was only natural that this legacy would be passed on to the state that held political sovereignty. In time, the Ottoman Principality became the center of this heritage. With Mehmed the conqueror [Fatih], the state entered a new phase and claimed the heritage of the East and the West.
This study will examine the impact of the new understanding that began with Fatih on Ottoman scientific thought and education. It will also try to reveal the influence of the Fatih complex on later madrasas and educational institutions. Our sources are the Fatih Foundation, and the studies based on it.
O TRABALHO INTERPROFISSIONAL NO CONTEXTO HOSPITALAR: CORRELACIONANDO AS ESCALAS ECE X EJARCI
Authors: Montenegro Braz Gomes Hérica , Figueiredo Marti Gabriella , Guimarães dos Santos Almeida Rodrigo , Guedes de Brito Geraldo Eduardo , Pires Batiston Adriane
Published: December 2024

O presente artigo se propõe a analisar a associação entre as atitudes relacionadas à colaboração interprofissional e o clima de equipe entre profissionais de saúde de um Hospital Universitário. Foram aplicadas a Escala Jefferson de Atitudes Relacionadas à Colaboração Interprofissional (EJARCI) e a Escala de Clima de Equipe (ECE) associadas à caracterização sociodemográfica de 156 profissionais de seis setores atuantes em equipes formadas por no mínimo quatro categorias profissionais. Para realização dos testes estatísticos utilizou-se o software estatístico livre R. Não foi verificada associação estatística significativa entre a EJARCI com nenhuma das variáveis sociodemográficas empregadas no estudo. A ECE evidenciou correlações fortemente positivas e significantes entre a “participação na equipe” e “apoio para ideias novas”. Os itens presentes no fator “participação na equipe” foram os mais bem avaliados na ECE enquanto “orientação para as tarefas” menos pontuados. O estudo concluiu que os profissionais apresentam alto grau de disposição para a colaboração interprofissional e para o clima de equipe. Os achados apontam o trabalho interprofissional no contexto hospitalar carece de ferramentas que fortaleçam sua aplicabilidade bem como outros estudos.
ESTADO DA ARTE SOBRE VISUALIZAÇÃO DE DADOS: UMA REVISÃO SISTEMÁTICA SOBRE TABLEAU E POWER BI
Authors: Belo Angeluci Alan César , Gomes do Rosário Anne Vitória
Published: December 2024

Com o avanço tecnológico, o volume de dados e informações experimentou um crescimento exponencial, o que complexificou sua análise. A visualização de dados, seja por meio de gráficos ou outras representações gráficas, é crucial para destacar características dos dados e elucidar relações entre diferentes temas. Neste contexto, o presente estudo examina a utilização das ferramentas Tableau e Power BI para a visualização de dados na última década. Através de um levantamento bibliográfico e uma revisão sistemática, complementados pela Análise de Conteúdo conforme Bardin, com o auxílio do software Iramuteq, esta pesquisa visa mapear o estado da arte na área de visualização de dados dentro da Ciência da Informação e áreas afins. Os resultados esperados incluem um panorama detalhado das ferramentas de visualização de dados vigentes, seus usos predominantes e as projeções para futuros desenvolvimentos no campo.
Optimalisasi Kenyamanan Termal Rumah Tinggal Bali Kontemporer di Kabupaten Gianyar
Authors: Aryasutha I Made Krishna , Wendyputra I Putu Weka , Yudantini Ni Made , Ramadhan Try
Published: December 2024

Thermal comfort is an important aspect to achieve in residential buildings. Therefore, this research aims to optimize thermal comfort in residential buildings with Contemporary Balinese Architecture in one of the high-density areas in Bali, namely Gianyar Regency. This study aims to provide design strategy solutions through a descriptive quantitative method in the form of building model simulations using Autodesk Ecotect Analysis software. The optimization focuses on openings and the use of solar reflective paint on the building's exterior to achieve an optimal level of thermal comfort. The results of the case study show that the addition of openings and the use of solar reflective paint can help improve thermal comfort by reducing the MRT (Mean Radiant Temperature) in the building by 0.96°C. The PMV (Predicted Mean Vote) and PPD (Predicted Percentage of Dissatisfied) indices were also successfully improved compared to the existing conditions.

 
Preferensi Hunian Sementara bagi Penerima Manfaat Program Pengembangan Perumahan di Kawasan Kumuh Kelurahan Bira Makassar
Authors: Amalia Andi Annisa , Sarwadi Ahmad , Roychansyah Muhammad Sani
Published: December 2024

Temporary housing for beneficiaries of the Housing Development Program in the slum area of Kelurahan Bira Makassar is interesting to study because its fulfillment is pursued independently by target households. This research aims to understand their preferences for temporary housing during the development process. This research uses the grounded theory method with a content analysis approach and open coding technique. The results show that preferences for temporary housing include: (1) space needs such as bedrooms, toilets, and kitchens; (2) locations close to places of worship, health facilities, village offices, and permanent housing construction locations; and (3) free from rental fees. Beneficiary priority preferences include basic domestic needs that are short-term in nature. Understanding these preferences is important in designing settlements that are more suited to local needs based on the wishes and needs of residents.
Os Verbos de Atitude Proposicional Epistêmica em Construções Oracionais Completivas do PB: uma proposta construcional
Authors: Duarte Júlia Maria das Dores , Amaral Luana Lopes
Published: December 2024

Este artigo expõe os desdobramentos da pesquisa de Duarte (2022), em que é explorada a expressão da Atitude Proposicional Epistêmica de crença no português brasileiro por meio da relação entre os Complement-Taking Predicates, que são verbos que aceitam orações no complemento (como acreditar, achar, chutar e outros) e a Construção Oracional Completiva em si (Ela chutou que o resultado seria um a zero). Porém, em eventos como Ele chutou a bola, não há sentido epistêmico, sendo chutar interpretado como um verbo de ação em uma oração transitiva prototípica. O método foi de analisar 35 verbos e suas ocorrências. Com base em Croft (2022), propomos que a expressão da Atitude Proposicional Epistêmica de crença está relacionada com a Construção Oracional Completiva; todavia, o papel do verbo também é significativo: somente os verbos que denotam algum tipo de incerteza futura podem ser empregados como verbos de Atitude Proposicional Epistêmica de crença; ademais, esses verbos expressam a Atitude Proposicional Epistêmica de crença apenas quando inseridos na Construção Oracional Completiva.
Unraveling the yield heterosis formation of the Chinses cabbage hybrid by the comparative transcriptomic analysis and LHCB1 gene function analysis
Authors: Wang Ruihua , Han Min , Han Taili , Li Yuanyuan
Published: December 2024

Changes in gene expression in hybrids are closely related to the heterosis formation. Currently, few reports have been reported on key genes that promote the yield advantage formation in Chinese cabbage hybrid. In the present study, RNA sequencing and virus-induced gene silencing were performed to elucidate the underlying mechanisms of yield advantage formation in Chinese cabbage hybrid (weichunbai No.3). In total, 3652 and 2768 genes were differentially expressed genes between the Chinese cabbage hybrid and its parents in the rosette and the mature stages, respectively. These differentially expressed genes among the hybrid and its parents showed diverse expression patterns, and the overwhelming majority of differentially expressed genes were additively expressed genes. A vital additively expressed gene related to the plant weight, BraA09g035160.3C, was found by the weighted gene co-expression network analysis. Through virus-induced gene silencing technology, the expression level of BraA09g035160.3C in the hybrid was dramatically decreased, which resulted in slowing the hybrid growth, indicating that this gene could be related to the formation of hybrid yield advantage. These results will provide an important reference for in-depth research on the molecular mechanism underlying the yield advantage formation of Chinese cabbage hybrid.
Clinical Effects of Surgical Delay in Older Patients with Intertrochanteric Fractures: Analysis from the National Inpatient Sample Database
Authors: Pan Zhijie , Lin Yuning , Deng Haitang , Feng Wenjie , Shao Qingfeng , Zou Kai , Zhang Yang
Published: December 2024

The clinical effect of surgery timing in older patients with intertrochanteric fractures (IFs) is controversial. Our objective was to assess the association between surgery timing and in-hospital mortality and postoperative complications in these patients. In our study, 228,725 patients accepted internal fixation surgery for IFs were obtained from the 2002 to 2014 Nationwide inpatient sample (NIS) database. They were categorized into 3 subgroups according to the time of admission to surgery: early, shorter delays, and longer delays. The prevalence of internal fixation surgery in IFs patients significantly increased over time. Delays in surgery were associated with longer LOS, extra hospital charges, and higher risk of postoperative complications. Rates of in-hospital death were 2.110% and 4.214%, respectively in two delay groups. After adjustment, shorter delays was not associated with in-hospital death (OR: 1.024, CI: 0.953, 1.088;P = 0.520), longer delays was obviously associated with an increased risk of death during hospitalization (OR: 1.547, CI: 1.410, 1.696;P<0.001). Prolonged waiting time for surgery significantly increased the risk of developing adverse events. Therefore, reasonable preoperative optimization and strive for early surgery are necessary.
GypenosideXVII alleviates fear and anxiety like behavior in rats arising from post-traumatic stress disorder through the PERK/CHOP signaling pathway
Authors: Yang Yitai , Wang Jingjing , Wang Shuying , Chen Yueyang , Li Zemeng , Zhang Huimin , Zhou Pengbo , Li Wei , Ren Dangli , Sun Hongtao
Published: December 2024

Objective
Recent investigations suggest GP-17 may be effective in managing conditions like insomnia, depression, and Alzheimer's disease, primarily due to the qualities of anti-inflammatory, antioxidative, and neuroprotective.Studies reveal pathological imaging changes in the mPFC of PTSD patients, with animal experiments showing PERK-mediated activation of ER stress in the mPFC. To explore the potential role of GP-17 in the pathogenesis of PTSD.We carried out this study to assess the effects of Gypenoside XVII on PTSD-like behaviors and to further investigate the mechanisms underlying this process.The Single Prolonged Stress (SPS) model is extensively employed as a method to replicate post-traumatic stress disorder (PTSD).
Method
This research utilized standardized animal behavior tests, including the Open Field Test for anxiety-related behavior and the Conditioned Fear Test for fear-related responses, to explore the potential of Gypenoside XVII in reducing PTSD-like symptoms. Fear extinction was assessed using the Fear Extinction Test, highlighting deficits in fear extinction.The rats' medial prefrontal cortex subjected to SPS treatment was extracted, followed by the application of Western blotting and TUNEL apoptosis staining methods to investigate the mechanisms through which Gypenoside XVII mitigates PTSD-like behaviors.Additionally,through cellular experiments, we validated that GP-17 exerts its anti-apoptotic mechanism on BV2 cells by suppressing the endoplasmic reticulum(ER) stress signaling pathway.
Results
Gypenoside XVII was found to alleviate SPS-induced PTSD-like behaviors and mitigate deficits in fear extinction.In the brains of SPS model rats, PERK phosphorylation was markedly increased, driving the downstream activation of eif2a phosphorylation. This led to the over-activation of ATF4, which subsequently initiated CHOP transcription and triggered the apoptotic process. Intraperitoneal injection of Gypenoside XVII reversed these changes. Moreover, Tunicamycin (Tu) induces ER stress in BV2 cells, contributing to PERK phosphorylation and resulting in CHOP-induced apoptosis. Gypenoside XVII was able to inhibit the apoptosis triggered by the Overexpression of CHOP, a downstream component of the PERK signaling pathway in BV2 cells.
Conclusions
In this study, we observed that Gypenoside XVII can improve anxiety and fear extinction deficits in SPS model rats while inhibiting apoptosis in the mPFC brain tissue, likely by suppressing the activation of the PERK/CHOP signaling pathway induced by SPS in the mPFC. By targeting ER stress and inhibiting cortical cell apoptosis post-PTSD, Gypenoside XVII provides a new avenue for clinical treatment strategies.
Association Between Triglyceride-Glucose Index and 28-Day Mortality in Patients with Sepsis and Heart Failure: A Retrospective Study Using the MIMIC-IV Database.
Authors: Wu Yongchang , Chen Jiejing , Liao Ming , Deng Xilong , Li Yueping
Published: December 2024

Background
The triglyceride-glucose body mass index (TyG-BMI) is a surrogate marker for insulin resistance and has been identified as a predictor of cardiovascular diseases. However, its role in patients with sepsis and heart failure remains unclear. This study aims to explore the association between the TyG-BMI index and 28-day mortality in patients with sepsis and heart failure.
Methods
This retrospective observational cohort study used data from the Medical Information Mart for Intensive Care (MIMIC-IV) database. We identified patients with sepsis and heart failure and divided them into tertiles based on their TyG-BMI levels. The primary outcome was 28-day mortality, while secondary outcomes included 1-year mortality, in-hospital mortality, and ICU mortality. Cox proportional hazards regression and restricted cubic spline analysis were used to examine the association between TyG-BMI index and clinical outcomes in critically ill patients. Survival curves were estimated using the Kaplan-Meier (K-M) method, and subgroup analyses were performed.
Results
A total of 598 patients were included in this study, of whom 60.6% were male. The observed mortality rates were 35.7% at 28 days, 51.3% at 1 year, 28.1% in the ICU, and 34.5% in-hospital. Multivariable Cox proportional hazards analysis showed that patients in the lowest TyG-BMI tertile had a significantly higher risk of all-cause mortality. Compared to the lowest TyG-BMI group, the fully adjusted Cox model revealed hazard ratios (HRs) for 28-day, 1-year, ICU, and in-hospital mortality of 0.651 (95% CI: 0.468–0.904, p = 0.011), 0.597 (95% CI: 0.417–0.853, p = 0.004), 0.634 (95% CI: 0.455–0.883, p = 0.007), and 0.603 (95% CI: 0.457–0.797, p < 0.001), respectively. Kaplan-Meier analysis showed that higher TyG-BMI levels were associated with significantly lower all-cause mortality for 28-day, 1-year, ICU, and in-hospital outcomes (log-rank p = 0.02, p = 0.00087, p = 0.016, p = 0.019, respectively). Additionally, restricted cubic spline analysis indicated that lower TyG-BMI levels were associated with a gradual increase in all-cause mortality risk.
Conclusion
The TyG-BMI index is significantly associated with 28-day, 1-year, in-hospital, and ICU all-cause mortality in patients with sepsis and heart failure. Higher TyG-BMI levels are linked to a reduced risk of mortality, suggesting that the TyG-BMI index may be useful for identifying high-risk patients with sepsis and heart failure.
Study on the relationship between hyperthyroidism and immune function
Authors: Li Shuangshuang , Zhong Hui , Li Fangyi , Li Jinying , Shi Qiping
Published: December 2024

Objective
To elucidate the role of T helper (Th) cell immune and CD137 in the pathogenesis of hyperthyroidism, we analyzed the differences in the expression levels of cytokines and CD137 in peripheral blood monocytes (PBMC) among hyperthyroidism patients before and after the intervention of antithyroid drug (ATD) and normal subjects.
Methods
81 patients with hyperthyroidism diagnosed in the Department of Endocrinology of the First Affiliated Hospital of Jinan University from April 2021 to April 2022 were selected as the pre-intervention group, of which 25 patients were treated with ATD as the post-intervention group (the average treatment time was 129.84 days), and 83 cases of healthy medical subjects examined in our physical examination center as the normal group during the same period; We analyzed the differences in plasma concentrations of multiple cytokines, as well as the expression levels of sCD137 in plasma and CD137 on T and B lymphocytes.
Results
Patients with hyperthyroidism may have both pro-inflammatory and anti-inflammatory responses, and the immune responses of Th1, Th2, and Th17 may all be involved in the pathogenesis of hyperthyroidism, while patients with hyperthyroidism still have active immune responses after drug intervention; patients with hyperthyroidism may have humoral hyperimmunity before and after intervention, and the activation ability of T cells in patients with hyperthyroidism is enhanced.
Conclusion
These results showed that the expression of Th1, Th2, and Th17 cytokines was altered in hyperthyroidism patients and that the co-stimulatory molecule CD137 may be an important marker of immune activity in hyperthyroidism.
Improving accuracy and precisely controlling molten pool of stepped filling wire assisted DP-GTA-AM
Authors: ZHANG GANG , Wang Jianbo , Zhu Zhenwen , Li Lupeng , Shi Yu
Published: December 2024

Conventional wire arc additive manufacturing (WAAM) exhibits certain intrinsic characteristics, such as the strong coupling interaction between the arc-droplet and the weld pool, the non-linear time variation, and the heat accumulation, which result in poor deposition process and morphology. Higher accuracy of WAAM parts is still desirable for many industrial applications. This paper proposes a novel approach: double-pulsed gas tungsten arc welding additive manufacturing (DP-GTAW-AM) with stepped filling wire, aimed at independently controlling heat input and mass transfer in the WAAM process. We first illustrate its fundamental principles, followed by constructing the DP-GTAW-AM experimental system. Subsequently, several typical experiments using DP-GTAW-AM were successfully conducted to demonstrate the decoupling actions of heat and mass transmission. Furthermore, the droplet transfer behavior and molten pool stability, along with morphology changes as deposition layers increase, were thoroughly analyzed using visual images of deposition and mathematical modeling. The results indicate that a stable heat and mass transfer process, as well as a deposited layer morphology with desired accuracy, were ultimately achieved. It demonstrates the feasibility of improving the deposition accuracy of WAAM by adjusting pulse parameters. This approach may provide an effective method for precisely controlling the deposition accuracy of WAAM in industrial applications.
Rheumatic Heart Disease in a 14-Year-Old Boy with Aortic and Mitral Valve Involvement: A Case Report
Authors: Fatoke Babatunde , Richards Atinuke , Hassan Olayinka , Adekunle Misbau , Aremu Stephen Olaide
Published: December 2024

Background
Rheumatic heart disease (RHD) continues to pose significant health challenges, especially in adolescents, where it can lead to long-lasting complications. This case report discusses a teenage patient diagnosed with RHD following recurrent streptococcal infections, highlighting the clinical presentation, management, and outcomes.
Case Presentation:
The patient presented with chest pain, fatigue, and dyspnoea, prompting a comprehensive evaluation. An echocardiographic assessment revealed mitral valve regurgitation and left atrial enlargement. The management strategy focused on preventing further streptococcal infections through benzathine penicillin G as a key component of secondary prophylaxis. Inflammatory symptoms were addressed using high-dose aspirin and corticosteroids, while diuretics were utilized to alleviate heart failure symptoms. Additionally, anticoagulation therapy was initiated due to the patient’s atrial fibrillation, mitigating the risk of thromboembolic events. Regular follow-up appointments and echocardiographic evaluations were instituted to monitor cardiac function and the progression of valvular disease. The patient demonstrated significant improvement in symptoms and functional capacity, now classified as NYHA Class II heart failure.
Conclusion
This case underscores the necessity for early diagnosis, appropriate management, and long-term follow-up in adolescents with RHD to prevent complications and optimize patient outcomes. Moreover, it emphasizes the need for awareness and preventive strategies against rheumatic fever, a preventable cause of cardiovascular morbidity. Insights from this case contribute to understanding RHD in a paediatric context, advocating for a multifaceted care approach that includes patient education, dietary modifications, and lifestyle adjustments to enhance cardiovascular health.
Colposcopic Imaging Features and Missed Diagnoses in Cervical Adenocarcinoma In Situ: A Retrospective Study
Authors: Li Qing , Chen Limei , Zhang Hongwei , Wang Jue , Wang Qing , Sui Long , Cong Qing , Hua Keqin
Published: December 2024

Background
Cervical adenocarcinoma in situ (AIS) is difficult to diagnose during colposcopy due to its unusual appearance. There's a lack of literature on AIS in colposcopic imaging.
Method
In this retrospective study, data from patients at the Obstetrics and Gynecological Hospital of Fudan University from Jan 2019 to Dec 2023 were analyzed. Patients who were diagnosed with AIS through pathological examination following colposcopy were included. Data collected included patient age, cytological results, HPV results obtained within six months prior to colposcopy, colposcopic images, medical records, and pathology reports, as well as the results of the loop electrosurgical excision procedure (LEEP), if available. The study aimed to analyze clinical characteristics, colposcopic image features, and the causes of missed diagnoses during colposcopy.
Results
A total of 181 cases with a pathological diagnosis of AIS from colposcopy were included.Among the cases, 46.4% had NILM cytology, 17.1% showed AGC/AIS, and 84.5% were HPV 16/18+. Image reviews highlighted acetowhite epithelium and atypical vascular patterns. Reasons for missed diagnoses included lack of familiarity (43.9%) and inadequate visualization (24.4%). Cases with NILM cytology were more frequently missed, while non-missed cases had clearer lesion boundaries and a higher prevalence of AIS in both the cervix and canal
Conclusion
The presence of atypical colposcopic images in AIS patients heightens the risk of diagnostic oversight. By examining the colposcopic image characteristics of AIS patients, standardizing colposcopy procedures to ensure proper exposure of the cervix, and conducting endocervical curettage in non-pregnant women, the rate of missed diagnoses in AIS patients during colposcopy can be effectively decreased.
Factors associated with fruit and vegetable intake and physical activity among reproductive age women in Gofa and Basketo Zones, Southern Ethiopia: a community based cross-sectional study
Authors: Domba Markos Manote , Argefa Terefe Gelibo , Kebede Bahiru Mulatu
Published: December 2024

Background
The escalation in burdens of non-communicable diseases coupled with unmet needs of sexual and reproductive health services progressively impacting women, and posing significant threats to forthcoming generations. Low fruits and vegetables intake, and insufficient physical activity are known risk factors of NCDs. This research endeavors to assess the level and factors associated with fruit and/or vegetable intake and physical activity among women of reproductive age in Gofa and Basketo Zones, Southern Ethiopia.
Methods
A community based cross-sectional study was employed among reproductive age women from September 9/2022 to December 6/2022. A multistage cluster sampling was used to select participants from the designated zones. A total of 1404 study participants were included in the analysis. Statistical analysis was conducted using Statistical Package for the Social Sciences software encompassing descriptive statistics, bivariate analysis, and multivariate logistic regression. Associations were deemed statistically significant if the p-value was < 0.05.
Result
Prevalence of adequate fruit and/or vegetable (FV) intake and physical activity were 48.4% and 78.3% respectively. Women who were from younger age groups, getting advice from health professionals, having primary school education, having > 4 family size, women from households with the lower wealth status, widowed/separated and Gofa zone residents were more likely to have adequate FV intake. Being married, single and Basketo zone residence were positively associated with physical activity. However, women from older age groups and having lesser educational status were less likely to be physically active. Women who were rural residents and having no family history of NCD were more likely to have both adequate FV intake and physical activity.
Conclusion
A substantial gap exists between the recommended level and actual FV consumption and physical activity. They are associated with different socio-economic, knowledge and health system factors. However, these preventive factors are more influenced by rural residence, having no family history of NCD, women’s occupation. Therefore, NCD prevention would be more effective if they account specific determinants in their design. Policy and socio-political factors influencing the rise of NCD risk factors should also be addressed.
CYP2C19 polymorphism and clinical outcomes of patients with carotid artery stenting
Authors: Wang Weiye , Chen Xuanyu , Cui Ruxin , Song Boyan , Shang Desheng , Zhao Yilei , Hu Yunzhen , Yuan Huaiwu , Peng Guoping
Published: December 2024

Aim: To explore the association between cytochrome P450 family 2 subfamily C member 19 (CYP2C19) and clinical outcomes in patients undergoing carotid artery stenting (CAS).
Methods: This single-center, retrospective cohort study consecutively enrolled patients undergoing CAS and CYP2C19 polymorphism examination at the First Affiliated Hospital of Zhejiang University from January 2022 to November 2023. CYP2C19 polymorphisms were categorized into three groups based on their genotype: rapid, poor, and intermediate metabolizers. The primary outcome was stent thrombosis. Secondary outcomes included death, acute ischemic stroke or transient ischemic attack, acute coronary syndromes, and symptomatic bleeding. Logistic regression was used to evaluate the relative risk of outcomes in rapid metabolizers undergoing CAS compared with non-rapid metabolizers. Statistically significantly different variables among the three groups were added to the multivariable regression.
Results: A total of 196 patients were included in the final analysis, of whom 91.3% were males. The mean age was 69.8 ± 6.9 years. Fifty-eight patients were categorized as rapid metabolizers, 31 as poor metabolizers, and 107 as intermediate metabolizers. No significant difference in the incidence of stent thrombosis was found among the three groups within 90 days after CAS (p = 0.685) and over 90 days after CAS (p = 0.593). The rapid metabolizer group had a higher risk of stent thrombosis than the poor metabolizer group over the entire follow-up period (3.4% vs 3.2%, odds ratio [OR] = 0.785, 95% confidence interval [CI] = 0.147-4.181, p = 0.777), with no significant difference between the two groups within 90 days after CAS (1.7% vs3.2%, OR = 0.650, 95% CI = 0.092-4.605, p = 0.667) and over 90 days after CAS (0.0% vs 1.7%, OR = 1461, 95% CI = 0.000-, p = 0.998). Meanwhile, no significant difference was observed between the two groups regarding the incidence of death, IS or TIA, acute coronary syndromes, and symptomatic bleeding at the three time points, with or without the inclusion of covariates. Similarly, the relative risk of primary and secondary outcomes was not significant in the rapid compared with intermediate metabolizer groups at all time points.
Conclusion:CYP2C19 polymorphism is not associated with the clinical outcome in patients undergoing CAS. However, random controlled trials are needed to validate this finding.
Body composition as a novel biomarker of recurrence risk in patients with triple-negative breast cancer
Authors: Vis Jill B. De , Wang Cong , Nguyen Kirsten V. , Sun Lili , Jia Brigitte , Sherry Alexander D. , Alford-Holloway Mason N. , Balbach Meredith L. , Koyama Tatsuki , Chakravarthy A. Bapsi , Rafat Marjan
Published: December 2024

Background and Hypothesis Triple-negative breast cancer (TNBC) patients are at increased risk for recurrence compared to other subtypes of breast cancer. Previous evidence showed that adiposity may contribute to worsened cancer control. Current measures of obesity, such as body-mass index (BMI), are poor surrogates of adiposity, while visceral-to-subcutaneous adiposity ratio (VSR), which can be measured from routine computed tomography (CT) imaging, is a direct adiposity measure. We hypothesized that VSR is a stronger predictor of recurrence compared with BMI in patients with TNBC. Materials and Methods This study includes 162 women with stage I-III TNBC who completed standard of care therapy. Measures of body composition, including VSR, visceral adiposity (VA), and subcutaneous adiposity (SA), were estimated using a semi-automated quantitative imaging tool on CT images of the abdomen at the level of L2-L3. Anthropometric measures included BMI and waist circumference and were obtained from CT images. Associations of adiposity measures and recurrence risk were assessed using Fine and Gray competing risk models with death as a competing risk and age at diagnosis and clinical disease stage as covariates. Results During a median follow-up time of 3.6 years, 55 patients had recurrence. The median BMI at baseline was 30.2 [Quartiles: 26.3–35.2]. Body composition was not associated with overall or locoregional recurrence. VSR was significantly associated with an increased risk of distant recurrence, with a subdistribution hazard ratio of 4.25 (95% CI: 1.06–17.02), p = 0.041. By contrast, BMI was not associated with any recurrence risk. Conclusion Consistent with our hypothesis, VSR was associated with a significant risk of distant recurrence and therefore may be a prognostic biomarker. Future directions include interventions targeting VSR reduction among patients with TNBC and VSR-directed therapy modulation.
Safety and efficacy of sintilimab-based neoadjuvant immunochemotherapy for resectable esophageal squamous cell carcinoma: A pooled analysis
Authors: Lu Genlin , Tu Jinming , Tong Fei , Jiang Renya , Cai Zhai
Published: December 2024

Background Sintilimab, a fully human IgG4 monoclonal antibody that targets the programmed cell death receptor-1 (PD-1), blocks the interaction of PD-1 with its ligands, PD-L1 and PD-L2, thereby aiding in the restoration of the endogenous antitumor T-cell response. Although clinical trials for sintilimab-based neoadjuvant immunochemotherapy (sintilimab-based nICT) in resectable esophageal squamous cell carcinoma (ESCC) are increasing, comprehensive evaluations remain scarce. Methods PubMed, Embase, Cochrane Library, Web of Science, and ClinicalTrials.gov databases were searched for eligible studies up to May 30, 2024. The estimated outcomes were pathological complete response (pCR),major pathological response (MPR), objective response rate (ORR), disease control rate (DCR), complete remission (CR), partial remission (PR), stable disease (SD), and disease progression (PD),, TNM and N down-degrading rate, R0 surgical resection grade 3 or higher treatment-related adverse events(TRAEs ≥ 3), and anastomotic leakage(AL), disease free survival (DFS), and overall survival(OS). A random-effects model was used to integrate the pooled rate when heterogeneity was present. Results A total of 14 studies, involving 652 patients with resectable ESCC, were enrolled. The pooled rates were as follows: 27% (95% CI, 23%-30%) for pCR, 45% (95% CI, 36%-54%) for MPR, 65% (95% CI, 46%-82%) for ORR, 99% (95% CI, 96%-100%) for DCR, 18% (95% CI, 9%-25%) for CR, 53% (95% CI, 35%-71%) for PR, 32% (95% CI, 16%-51%) for SD, 1% (95% CI, 0%-3%) for PD, 87% (95% CI, 71%-97%) for one-year DFS, 94% (95% CI, 85%-99%) for one-year OS, 89% (95% CI, 84%-93%) for two-year OS, 69% (95% CI, 59%-79%) for TNM down-degrading, 67% (95% CI, 52%-82%) for N down-degrading, 98%(95% CI, 93%-100%) for R0 surgical resection,19% (95% CI, 13%-26%) for TRAEs ≥ 3,and 7% (95% CI, 4%-9%) for AL . Conclusions Sintilimab-based nICT exhibits a safe and efficacious profile for the treatment of resectable ESCC.
Surgical Treatment of Hemorrhagic Complications of Age- Related Macular Degeneration, Predictive Factors and Outcomes
Authors: Valaskova Jela , Vesely Pavol , Krasnik Vladimir , Popov Ivajlo , Juhas Jan , Waczulikova Iveta , Furdova Alena
Published: December 2024

Purpose:
The objective of this study was to evaluate the functional and clinical outcome of submacular hemorrhage (SMH) in age related macular degeneration (ARMD) displacement using pneumatic displacement with intravitreal expansile gas by 23Gauge pars plana vitrectomy with subretinal injection of recombinant tissue plasminogen activator (rtPA).
Patients and methods:
Retrospective interventional case series of 58 pseudophakic patients, who underwent surgical treatment with inclusion criteria: subretinal, subretinal pigment epithelium (subRPE), or combined central hemorrhage associated with ARMD, 23 Gauge pars plana vitrectomy using rtPA sulfur hexafluoride (SF6). Patients were classified according to the clinical picture, the size of the hemorrhage, into group with small hemorrhage up to 2x2 papillary diameter (PD) 32 eyes, moderate hemorrhage (up to 4x4PD, to the arcades) 19 eyes and massive hemorrhage (from 5x5PD hemorrhage through the arcades to the periphery) 7 eyes. Medical records were reviewed for diagnosis, logMAR best corrected visual acuity (BCVA), preop and postop clinical findings, complications, and all medical history up to 6 months after surgery.
Results:
Improvement of average postoperative BCVA was the best in group with moderate extension of hemorrhage, 1.58 logMAR preoperative to 1.14 logMAR postoperative. Improvement of average postoperative BCVA was the best in group with shortest medical history of hemorrhage (up to 7 days). Age was not a crucial predictive factor. Regarding association between hemorrhage category and clinical outcome, there was a significant positive association between the hemorrhage size before the operation and the scored clinical outcome. In association between anticoagulant treatment (ACT) and clinical outcome there was negative, but not significant association between the treatment and the scored clinical outcome (P = 0.5197).
Comorbidities, as diabetes mellitus or arterial hypertension after adjustment on the baseline and ACT were not significantly associated with worsened vision measured on the LogMAR scale.
Conclusion:
We consider surgical treatment of the hemorrhagic complication of ARMD to be beneficial, massive hemorrhages have a worse prognosis for improving BCVA than moderate and small hemorrhages. Anticoagulants are associated with massive hemorrhage and, at the same time, with the better postoperative BCVA than massive hemorrhage without total ACT.
Prognostic Value of Right Ventricular Free-Wall Longitudinal Strain Compared to Conventional Echocardiographic Parameters in Tricuspid Regurgitation: A Systematic Review and Meta-Analysis
Authors: Yamaguchi Mika , Nabeshima Yosuke , Takeuchi Masaaki , Node Koichi
Published: December 2024

PURPOSE: Hemodynamically significant tricuspid regurgitation (TR) often leads to right ventricular (RV) dysfunction, which is associated with poor outcome. Estimation of RV function is difficult using conventional echocardiographic parameters.. We aimed to compare the association of right ventricular free-wall longitudinal strain (RVfwLS) with outcome to that of conventional RV function parameters in TR. METHODS: A systematic review and meta-analysis were conducted per PRISMA guidelines. PubMed and Scopus databases were searched for studies reporting the association of RVfwLS with adverse outcomes such as all-cause mortality and cardiopulmonary events. Studies that reported hazard ratios (HRs) of RVfwLS, tricuspid annular plane systolic excursion (TAPSE), RV fractional area change (RVFAC), and systolic pulmonary arterial pressure (sPAP) were also collected. HRs were pooled using a random-effects model, and ratio of HR per 1 standard deviation change between RVfwLS and other parameters were calculated for direct comparison. Subgroup analyses were conducted to assess variations by study design and outcome measures. RESULTS: Of 4,288 publications, 11 studies involving 12 patient cohorts were included for analysis. Mean age was 71 years, with follow-up periods ranging from 18 to 60 months. RVfwLS was associated with outcome (HR: 1.09, 95% confidence interval: 1.07–1.12). RVfwLS showed a significantly stronger association with adverse outcomes than TAPSE, RVFAC, and sPAP. CONCLUSION: RVfwLS is a more accurate predictor of adverse outcomes than conventional parameters in patients with TR, suggesting its potential role in managing patients.
Effect of Irrigation Frequency and Weed Management on Growth and Yield of Sesame
Authors: Islam Zohirul , I Prof Dr Md. Shahidul , syfullah khalid
Published: December 2024

This study evaluates the impact of irrigation frequency and weed management on the growth and yield of sesame (Sesamum indicum L.), conducted at Sher-e-Bangla Agricultural University, Bangladesh. A split-plot design with four irrigation levels and four weed management strategies was employed. Results indicated that three irrigations at 20, 40, and 60 days after sowing significantly enhanced plant height, branch number, and seed yield. Weed control using herbicide applications and manual weeding effectively minimized competition, leading to improved crop performance. The findings emphasize the importance of efficient water use and integrated weed management in maximizing sesame productivity.