bluuebunny/crossref_metadata_2025 huggingface dataset:
Optical coherence tomography angiography of the macular retina in primary angle closure glaucoma
Authors: Zhang Yang , Zhang Shunhua , Wu Chan , Zhang Yao , Bian Ailing , Zhou Qi , Cheng Gangwei , Li Lue , Zhong Yong
Published: May 2019

Background: To detect the macular vessel density (MVD) changes in primary angle closure glaucoma (PACG) and to investigate the correlation between MVD and other glaucomatous changes.
Methods: A case-control study. Eyes of 22 PACG patients with an episode of acute primary angle closure (APAC) in one of the two eyes. Structural OCT scans were used to obtain peripapillary retinal nerve fiber layer (RNFL), macular ganglion cell complex (GCC) thickness and C/D area ration. OCT angiography (OCTA) was used to measure MVD.
Results: In the control group, the dense macular blood vessels were visible on OCTA， the macular vessels were sparse in the case group, and with an enlarged fovea avascular zone. There was a reduction in MVD in the case group compared with the controls (P<0.01). No correlations between MVD, VF mean deviation (MD), C/D area ratio, GCC thickness or RNFL thickness were found in the control group. In the case group, the Pearson correlation analysis showed that MVD was significantly correlated with BCVA (r=0,65, P=0.001), GCC (r=0.50, P=0.018) and VF MD (r=-0.54, P=0.009). In the case group, the multiple stepwise regression analysis, in which MVD were considered the dependent variables, showed that BCVA and GCC were significant predictors.
Conclusions: Macular microvascular network attenuated and MVD reduced significantly caused by APAC. MVD was strongly linked to BCVA and GCC.
Terson syndrome with macular hole: A case report
Authors: Qi Hui , Yan tao hong , Cheng Yan , Zuo Ling
Published: May 2019

Background

Terson’s syndrome with macular hole (MH) is rarely seen, and the mechanism of which is not clear. Here we report a case of Terson Syndrome with the inner limiting membrane (ILM) peeled off spontaneously associated with a rare finding: MH. Case presentation This report presents the case of a 36-year-old female patient with aneurysmal subarachnoid hemorrhage (SAH) and Terson syndrome in the right eye was admitted to our hospital with blurred vision in August 2018. Pas plana vitrectomy (PPV) was performed in the right eye, a hyaloid detachment and dyeing of the ILM with indocyanine green (ICG) was assisted. After removal of the vitreous hemorrhage (VH), a full-thickness MH was noted and we also noticed a particular aspect: the ILM was already peeled spontaneously. So we conducted gas tamponade, and face-down positioning after PPV. At two weeks follow-up, spectral domain optical coherence tomography (SD-OCT) confirmed that the MH had closed, while the thickness of nasal retina was 0.137 nm thicker than that in the temporal side. Her best corrected visual acuity (BCVA) was 0.15 in the right eye and 1.0 in the left eye. Conclusions MH is a rarely seen complication of Terson Syndrome. We conferred that the pathogenic mechanisms of this unusual MH may include stretching forces at the ILM-macular interface.
Bioengineering of malaria vectors, anopheles mosquitoes (Diptera: Culicidae) as a control strategy: An overview
Authors: Ileke Kayode David , Olabimi Isaac Omotayo
Published: May 2019

Disease in any form is undesirable in any human population. Malaria is a communicable disease that is vectored by female Anopheles mosquitoes. It is the leading vector transmitted disease in terms of the number of morbidity and mortality accounting for over 200 million cases annually. Several control measures have been employed by man over the years to control the vector which will in turn lead to the control of the diseases with the popular ones involving the use of insecticidal nets and indoor residual spraying of insecticides. However, these control measures have their various pitfalls. The use of genetically modified mosquitoes (GMMs) through bioengineering may be a promising method of reducing malaria vector population in our environment. This process involves population replacement technique (PRT) and population suppression techniques (PST). With proper integration of GMMs into the already existing control measures employed in the management of mosquitoes, a remarkable decrease in the prevalence of malaria is envisaged.
Effects of plants diversity on soil bacteria load in a tropical moist forest of Otuoke, Nigeria
Authors: Unanonwi Okpo Esio , Odebunmi Michael Adeoye
Published: May 2019

Most attempts towards forest management are directed towards management of forest resources which does not embrace other players. Key players in forest ecosystem are bacteria and fungi. Relationships between forests stand density and diversity with soil microbial population is an area of research that could aid in forest ecosystem management, this study was undertaken to provide the needed information. Three locations A, B, C of plot size 100 m x 100 m were purposefully selected. Site A and B were selected based on species richness and heterogeneity, while C was based on dominance and homogeneity. These were further divided into 25 m x 25 m subplots, and finally divided into 2 m x 2 m sample plots for investigation. Three of these were randomly selected from each site for identification and listing. Soil samples were collected across sites, inoculated, cultured and analyzed in the laboratory to estimate microbial population and identify microbial genera's. Species diversity were calculated using Shannon (H'), Simpson (D) and Sorensen's Coefficient (CC) indices. Bacteria and their colony forming units were calculated for sites. Results shows mean values of plant species diversity and mean values of bacteria counts were significantly (p < 0.05) different across the locations. Location A has a mean value 4.781 +/- 0.00 for Simpson Index, with mean bacteria load of 2.11 +/- 0.012 and 1.5115 +/- 0.00 for Shannon Index with very high level of diversity. Location B has moderate level of diversity with mean index of 3.675 +/- 0.00 for Simpson, and 1.375 +/- 0.00 for Shannon Indices, with mean bacteria load 2.40 +/- 0.21. Similarity content for locations A and B was 0.444. Plants diversity and bacteria load were positively significantly (p < 0.05) correlated with r2 of 76%. Increasing plants diversity will increase soil bacteria load. This would aid decisions making in forest conservation and ecosystem management.
Residual effects of neem Azadirachta indica A. Juss. (Sapindales: Meliaceae) seed-based fertilizer and NPK on the performance of Basella alba L. (Caryophyllales: Basellaceae) plant
Authors: Adejoro S. A. , Arije D. N. , Adegaye A. C.
Published: May 2019

Organomineral formulations are low input technology fertilizers, which combine the attributes of both organic and inorganic fertilizers. A completely randomized design (CRD) pot experiment was conducted in the screen house of the Department of Crop, Soil and Pest Management, of the Federal University of Technology, Akure, to evaluate the residual effects of neem Azadirachta indica A. Juss. (Sapindales: Meliaceae) seed based fertilizer and NPK 20:10:10 on the growth, yield and nutritional quality of Basella alba L. (Caryophyllales: Basellaceae). Results showed that the plots previously treated with neem seed-based fertilizer especially at 150-300 kg/ha enhanced the growth, yield and nutritional quality of B. alba, and increased these parameter significantly (P < 0.05) compared to the NPK treated and the untreated soil samples. It was therefore concluded that the Neem seed based fertilizer can serve as a viable alternative to NPK chemical fertilizers especially in rotational cropping systems owing to its prolonged soil action.
Efficiency of Acalypha wilkesiana (Muell Arg.) leaf oil extract applied as a biocide against Callosobruchus maculatus (F.) (Coleoptera: Bruchidae)
Authors: Oni Mercy Olayinka
Published: May 2019

The ethanolic oil extracts of Acalypha wilkesiana was assayed for its biotoxicity against the survival of Callosobruchus maculatus, immature stages, damage and seed weight-loss. The result was dosage and time of exposure dependent. The contact treatment revealed A. wilkesiana oil as an applicable biocide as it significantly (p < 0.05) affect the survival rate, suppressed oviposition and adult emergence of C. maculatus, hence reduced seed damage and weight-loss in grains below economic injury level. Contact treatment were the most toxic with LD50 values of 3.97 and 5.85 at 72 h, significantly lower (p < 0.05) than fumigant values 4.16 and 6.04, suggesting its isolation for future biocide study to establish the dose and mode of action for commercialization in crop protection.
Utilisation of common leafy vegetables in the diets of giant West African snail Archachatina marginata (Swainson, 1821) (Stylommatophora: Achatinidae)
Authors: Amobi Maduabuchi Inwele , Ezewudo Bede Izuchukwu
Published: May 2019

A study was conducted to evaluate the effects of utilisation of three leafy vegetable diets (bitter leaf Vernonia amygdalina, fluted pumpkin leaf Telfairia occidentalis and pawpaw leaf Carica papaya) on the growth performance of giant West African snail Archachatina marginata. A total of 90 A. marginata were used for the study. 30 snails were also subjected to three different dietary treatments in three replicates of 10 snails per replicate and fed with the fresh leaves of these vegetables over a period of 12 weeks. Results obtained recorded significant differences (P < 0.05) in terms of weight gain, shell length, shell circumference and shell thickness. On the whole, Archachatina marginata fed on fluted pumpkin leaf performed better in terms of mean weight gain when compared with those fed on bitter and pawpaw leaves. On the other hand, snails fed on pawpaw leaf had the best mean shell length gain, mean shell circumference and mean shell thickness when compared with those fed on bitter and fluted pumpkin leaves. The result clearly showed that the tested leafy vegetables can be successfully utilised as diets for rearing of A. marginata. For farmers to achieve better result, the inclusion of fluted pumpkin and pawpaw leaves in the diets of Archachatina marginata is highly recommended in snail rearing businesses.
Assessing AquaCrop model to simulate soil water contents under semi arid climate of Central Tunisia
Authors: Ghazouani Hiba , Latrech Basma , Amel Mguidich Belhaj , Amani Cherni , Douh Boutheina M. , Issam Ghazouani , Boujelben Abdelhamid
Published: May 2019

The objective of the present study was to preliminary calibrate and validate AquaCrop model based on crop conservative parameters from the literature for plant growth and water stress thresholds. In addition, physical soil characteristics, root growth, duration of plant stages and atmospheric demands were introduced according to field measurements. Based on this preliminary calibration, simulated water contents were compared to a measured data set of water contents retrieved from deficit and full irrigation treatments on a potato cropped field during an experimental year of 2015. Statistical indexes were computed and finally this performance in simulating water contents were validated under independent measurements carried out during an experiments campaign on the same field on 2014. Moreover, the paper presents the experimental protocol followed for soil characterization, considered as a milestone component for this soil water contents prediction. Results showed, that under the followed preliminary calibration, the model was able to simulate water contents (0v). In general, values of Root Mean Square Error were lower than 0.03 cm3.cm-3 representing the magnitude of error of the time domain reflectometry probe. Moreover values of Nash coffecients were close to 1 confirming the goodness of fit between measured and estimated water contents. Once assessed, the model could be used to study effects of different irrigation strategies on dynamic of water contents aiming to increase water use efficiency.
Análisis psicométrico de la versión revisada de la escala de fortalezas internas y externas para adolescentes (FIE-AR)
Authors: Betancourt Ocampo Diana , Andrade Palos Patricia , Marín Martínez Adriana
Published: May 2019

En el presente artículo se hace un análisis teórico desde el discurso de Freud acerca de las vicisitudes de las posiciones subjetivas del odio insertadas en dinámicas de intolerancia a la alteridad y a la diferencia. El método utilizado fue la revisión teórica documental y la desconstrucción de los textos como apertura de sentido, haciendo un recorrido por la obra de Freud, así como por otros referentes del pensamiento psicoanalítico. El objetivo consiste en analizar las incidencias del odio como problemática de actualidad, enlazando al psicoanálisis con las dimensiones sociales y culturales. Como resultado se puede revelar el papel fundante del odio en las relaciones con la alteridad inserta en el mundo exterior y se vislumbra la ilusoria alteridad amable del narcisismo; así como también se detectan los efectos delirantes del rechazo de la identidad amorosa homosexual. Se concluye el despliegue de la diferencia como riesgo y amenaza al narcisismo de la posición fálica o del amor de sí, mostrando un escenario del odio a las pequeñas diferencias bajo el moldeamiento de un estado de suspicacia feroz volcado en una postura de intransigencia que se extiende esde el mítico padre primordial hasta el Dios celoso de su unicidad.
Campañas de gobierno en Bogotá (1995-2015): significado de ciudad y de la cultura ciudadana
Authors: Garzón Medina Carolina , Sánchez Arismendi Aidaluz
Published: May 2019

Objetivo: comprender el significado de ciudad y de cultura ciudadana, a partir de las campañas de los gobiernos distritales de Bogotá en los últimos 20 años y su contrastación con las necesidades e intereses del joven ciudadano actual de diferentes localidades, fue el propósito de esta investigación. Metodología: desde la metodología cualitativa se tomó como soporte de análisis la teoría fundada y el método del interaccionismo simbólico; se utilizaron como referente teórico-empírico los aportes de la sociología urbana y el marketing urbano en una primera fase; la observación participante y sesiones de grupo focal en la comprensión de las percepciones sobre la gestión y el significado de ciudad en el joven actual, con respecto a la segunda fase. Resultados y conclusión: se identificó la diferencia entre el modelo de ciudad y cultura ciudadana, en cada gobierno, encontrando miradas disímiles como lo son las neo-institucionalistas, urbanistas y del derecho a la ciudad. Para el caso de los jóvenes actuales, se identificó que se mantienen algunas necesidades presentes en periodos anteriores y la innegable presencia de los procesos globalizadores en la conformación de la ciudad.
Ensuring transparency of key public finance authorities
Authors: Bukhtiarova Alina , Dukhno Yuliia , Kulish Ganna , Kurochkina Iryna , Lypchanskyi Volodymyr
Published: May 2019

Nowadays, there is a constant need for managing large amounts of information in public finances to identify existing and prevent future cases of illegal use of financial resources of citizens. The openness of information of key public finance authorities has a powerful anti-corruption effect and has a beneficial effect on economic development, while transparency of public finances is a factor in the successful implementation of the reform of all spheres of the economy.The purpose of the article is to develop a methodology for assessing the institutional and political transparency of the leading public finance authorities in Ukraine and its practical application on the example of the Ministry of Finance and the State Fiscal Service of Ukraine. The methodology includes six main stages, based on which the transparency index of public finance authorities was calculated. Constant calculations of the index will motivate the interaction of stakeholders and non-governmental organizations to increase the openness of public finance authorities in public finances, and the digital data settlements themselves can be used to develop recommendations to increase the level of transparency of the activities of key public finance authorities. Approbation of the developed transparency index of public finance authorities on the example of the Ministry of Finance and the State Fiscal Service of Ukraine made it possible to calculate the percentage of openness of data published by the indicated institutions. Based on quantitative calculations, practical recommendations were made for improving the completeness, reliability, availability and timeliness of published information.
Narratives of border reinforcement: The role of knowledge and communications power
Authors: Peña Sergio
Published: May 2019

The general objective of this paper is to analyze and explain the paradox of why objective knowledge based upon “facts and hard data” has been insufficient to forge a narrative, particularly in the U.S. side, that would lead towards a deeper cooperation and make the U.S.-Mexico border more fluid, functional and integrated. The main question is:  why the “re-territorialization” narrative of reinforcing differences and solidifying the border has prevailed? The theoretical framework that guides this analysis is the Aristotelian concept of “phronesis” or “practical wisdom” to settle beliefs that cannot be reached through an objective scientific rationality. The issue of power is of great interest in this analysis; particularly, the paper explores the relationship between knowledge and communications power as explanatory factors to understand the forging of a narrative of reinforcing borders. The conclusion is that the military-surveillance industrial complex has been the most influential actor behind the kind of knowledge that shape border policy compared to academic and scientific knowledge.
Synthesis and in vitro Antitumor Effect of New Vindoline Derivatives Coupled with Triphenylphosphine
Authors: Keglevich András , Szigetvári Áron , Dékány Miklós , Szántay Csaba , Keglevich Péter , Hazai László
Published: May 2019

An important approach to the development of new antitumor agents is the synthesis of conjugates containing two or more structural units. Taking this into consideration, vindoline derivatives were coupled with triphenylphosphine, to afford the expected phosphonium salts. The new hybrid entities were characterized by NMR spectroscopy, and their anticancer activity was also evaluated.
Improving Adherence to Ticagrelor in Patients After Acute Coronary Syndrome: Results from the PROGRESS Trial
Authors: Crisci Mario , Gragnano Felice , Di Maio Marco , Diana Vincenzo , Moscarella Elisabetta , Pariggiano Ivana , Di Maio Dario , Concilio Claudia , Taglialatela Vittorio , Fimiani Fabio , Cesaro Arturo , Cirillo Plinio L. , Calabrò Paolo
Published: May 2019

Background:

Dual antiplatelet therapy (DAPT) with aspirin and ticagrelor is recommended
for at least 12 months in patients after an acute coronary syndrome (ACS). However, its underuse and
premature discontinuation are common in clinical practice. We aimed to investigate the impact of a
dedicated follow-up strategy with clinical visits and counselling on adherence levels to ticagrelor in
patients after ACS.

Methods:

PROGRESS (PROmotinG dual antiplatelet therapy adheREnce in the setting of acute coronary
Syndromes) is a prospective, randomized trial enrolling 400 ACS patients treated with ticagrelor.
Patients were randomized to be followed-up in a dedicated outpatient clinic (In-person follow-up group,
[IN-FU], n=200), or with scheduled for phone interviews only (Telephone follow-up group [TEL-FU],
n=200), to assess ticagrelor adherence and related complications. DAPT disruption was defined as an
interruption of the administration of the drug due to complications or other reasons of non-adherence,
and divided according to the duration into short (1-5 days), temporary (6-30 days) and permanent (≥30
days) disruption. The primary endpoint was the rate of DAPT disruption at 1-year follow-up.

Results:

The rate of ticagrelor disruption at 1 year follow-up was higher in the TEL-FU group than in
the IN-FU group (19.6 vs 5.5%; p<0.0001). The IN-FU group reported a significantly lower rate of short
(3.0 vs 8.5%; p=0.012) and permanent (2.0 vs 9.6%; p=0.012) disruption than TEL-FU group. The rate
of major bleeding did not differ significantly between the 2 groups (p=0.450).

Conclusion:

The PROGRESS trial showed a net reduction in DAPT disruption in patients followed-up
with clinical (in-person) follow-up visits in a dedicated outpatient clinic compared with those scheduled
for phone interviews only.
The Effects of Hemocoagulase on Coagulation Factors in an Elderly Patient with Upper Gastrointestinal Hemorrhage: A Case Report
Authors: Zhang Haiyan
Published: May 2019

Background:

Hemocoagulase agkistrodon has been widely used for visceral bleeding,
however, its adverse reaction has not been fully recognized.

Case Report:

A 65-year-old female with upper gastrointestinal hemorrhage occurred severe coagulation
disorder during her hospitalization. Transfusion of blood products can not improve coagulation
function. Coagulation parameters returned to normal two days after discontinuation of hemocoagulase
agkistrodon.

Conclusion:

So intravenous administration of hemocoagulase should be cautiously used for the
treatment of gastrointestinal bleeding.
Is routine detailed screening tests in healthy children necessary?
Authors: KALYONCU Derya
Published: May 2019

Background: The aim of the study was to determine if routine
detailed screening tests in healthy children are needed or not. Methods: A total of 590 healthy
children (mean age: 9.7±2.9 years, M/F: 286/304) who were referred from primary
care providers for screening tests were evaluated retrospectively in terms of
laboratory findings such as complete blood count, lipid profiles, liver and
kidney function tests.  Results: Iron deficiency anemia was
significantly more common in teenage girls than boys. Only 16.7% of girls and
16.4% of boys had lipid abnormalities. The other biochemical parameters were
within normal limits in both groups. Conclusions:
No significant difference was observed in biochemical parameters in healthy
children. Thus, unnecessary tests should not be done in healthy children by
primary care physicians.Amaç:
Çalışmanın amacı sağlıklı çocuklarda rutin ayrıntılı tarama testlerine gerek
olup olmadığını değerlendirmektir. Gereç
ve yöntem: Çalışmaya aile hekimleri tarafından tarama testlerinin yapılması
için tarafımıza yönlendirilen 590 sağlıklı çocuk (ortalama yaş: 9.7±2,9 yıl,
E/K:286/304) alınmıştır. Çalışılan test sonuçları (tam kan sayımı, lipit
düzeyleri, karaciğer ve böbrek fonksiyon testleri, tiroid testleri)
retrospektif olarak değerlendirilmiştir. Bulgular:
Demir eksikliğine bağlı anemi ergen kız çocuklarında erkeklere oranla daha sık
saptanmıştır. Lipit bozuklukları kızlarda %16,7, erkeklerde %16,4 oranında
saptanmıştır. Diğer biyokimyasal parametreler normal tespit edilmiştir.  Sonuç:
Sağlıklı çocuklarda ayrıntılı biyokimyasal testler açısından istatistiksel
olarak anlamlı patoloji saptanmamıştır. Bu nedenle, maliyet de düşünüldüğünde
aile hekimleri tarafından gereksiz testler istenilmemeli ve bu konuda aile
hekimleri bilgilendirilmelidir.
The Fatalism Approaches According to The Frequency of Occupational Accidents and Other Sociodemographic Characteristics of Health Workers
Authors: UZUNTARLA Yasin , UZUNTARLA Fatma
Published: May 2019

Introduction: In this study, it is aimed to examine the fatalism approaches according
to the frequency of occupational accidents and other sociodemographic
characteristics of employees of a training and research hospital. Method: This descriptive study was
conducted with healthcare personnel working in a training and research
hospital. 500 healthcare personnel participated in the study. Survey method was
used as data collection tool, and Fatalism Scale for the occupational accidents
was used. SPSS 22 statistical program was used in the evaluation of data. Results: Of the participants, 53.2%
were female, 59.6% were married, 42% were under the age of 30, 68.8% were
university graduates, 34.8% had income between 3501-6000 TL, 35.2% were nurses,
and 46.2% had a professional experience of over 11 years, 50.8% did not have
work accidents, 39.0% had 1-3 times, 10.2% had 4 or more occupational
accidents. Mean score of the Fatalism Scale for the occupational accidents of
the healthcare personnel was found as (14.9±4.9). Significant differences were
found in fatalism approaches according to participants’ gender and occupation
(p < 0.05). Conclusion: The
training and research hospital workers' level of fatalism approaches towards
occupational accidents are found low. Employees' awareness of the importance of
safety precautions to prevent occupational accidents should be increased,
especially for the auxiliary staff.Giriş: Bu çalışma, ile
bir eğitim ve araştırma hastanesinde çalışanların iş kazası geçirme sıklığı ve
diğer sosyodemografik özelliklerine göre kadercilik yaklaşımlarının incelenmesi
amaçlanmıştır. Yöntem: Tanımlayıcı
nitelikteki bu çalışma, bir eğitim ve araştırma hastanesinde görev yapan sağlık
personelleriyle gerçekleştirilmiştir. Araştırmaya 500 sağlık personeli
katılmıştır. Araştırmada, veri toplama aracı olarak anket yöntemi kullanılmış
ve iş kazalarına yönelik kadercilik ölçeğinden yararlanılmıştır. Araştırma verilerinin
değerlendirilmesinde SPSS 22 istatistik programı kullanılmıştır. Bulgular: Çalışmamızda, katılımcıların
%53,2’sinin kadın, %59,6’sının evli, %42,0’sinin 30 yaşın altında, %68,8’inin
üniversite mezunu, %34,8’inin 3501-6000 TL arası gelire sahip olduğu,
%35,2’sinin hemşire, %46,2’sinin 11 yıl ve üzerinde mesleki deneyimi olduğu,
%50,8’inin iş kazası geçirmediği, %39,0’unun 1-3 kez, %10,2’sinin 4 veya daha
fazla iş kazası geçirdiği bulunmuştur. Sağlık çalışanlarının iş kazalarına
yönelik kadercilik puan ortalaması (14,9±4,9) olarak saptanmıştır.
Katılımcıların cinsiyetine ve mesleklerine göre kadercilik yaklaşımlarında
anlamlı farklılık bulunmuştur (p<0,05). Sonuç:
Sağlık çalışanlarının iş kazalarına yönelik kadercilik yaklaşım düzeyleri düşük
bulunmuştur. Yardımcı personel başta olmak üzere, çalışanların iş kazalarını
önlemede güvenlik tedbirlerinin önemine yönelik farkındalıkları artırılmalıdır.
Optimizing Antihypertensive Medication Classification in Electronic Health Record-Based Data: Classification System Development and Methodological Comparison (Preprint)
Authors: McDonough Caitrin W , Smith Steven M , Cooper-DeHoff Rhonda M , Hogan William R
Published: May 2019

BACKGROUND

Computable phenotypes have the ability to utilize data within the electronic health record (EHR) to identify patients with certain characteristics. Many computable phenotypes rely on multiple types of data within the EHR including prescription drug information. Hypertension (HTN)-related computable phenotypes are particularly dependent on the correct classification of antihypertensive prescription drug information, as well as corresponding diagnoses and blood pressure information.

OBJECTIVE

This study aimed to create an antihypertensive drug classification system to be utilized with EHR-based data as part of HTN-related computable phenotypes.

METHODS

We compared 4 different antihypertensive drug classification systems based off of 4 different methodologies and terminologies, including 3 RxNorm Concept Unique Identifier (RxCUI)–based classifications and 1 medication name–based classification. The RxCUI-based classifications utilized data from (1) the Drug Ontology, (2) the new Medication Reference Terminology, and (3) the Anatomical Therapeutic Chemical Classification System and DrugBank, whereas the medication name–based classification relied on antihypertensive drug names. Each classification system was applied to EHR-based prescription drug data from hypertensive patients in the OneFlorida Data Trust.

RESULTS

There were 13,627 unique RxCUIs and 8025 unique medication names from the 13,879,046 prescriptions. We observed a broad overlap between the 4 methods, with 84.1% (691/822) to 95.3% (695/729) of terms overlapping pairwise between the different classification methods. Key differences arose from drug products with multiple dosage forms, drug products with an indication of benign prostatic hyperplasia, drug products that contain more than 1 ingredient (combination products), and terms within the classification systems corresponding to retired or obsolete RxCUIs.

CONCLUSIONS

In total, 2 antihypertensive drug classifications were constructed, one based on RxCUIs and one based on medication name, that can be used in future computable phenotypes that require antihypertensive drug classifications.
Influence of Scribes on Patient-Physician Communication in Primary Care Encounters: Mixed Methods Study (Preprint)
Authors: Danak Shivang U , Guetterman Timothy C , Plegue Melissa A , Holmstrom Heather L , Kadri Reema , Duthler Alexander , Yoo Anne , Buis Lorraine R
Published: May 2019

BACKGROUND

With the increasing adoption of electronic health record (EHR) systems, documentation-related burdens have been increasing for health care providers. Recent estimates indicate that primary care providers spend about one-half of their workdays interacting with the EHR, of which about half is focused on clerical tasks. To reduce documentation burdens associated with the EHR, health care systems and physician practices are increasingly implementing medical scribes to assist providers with real-time documentation. Scribes are typically unlicensed paraprofessionals who assist health care providers by
documenting notes electronically under the direction of a licensed practitioner or physician in real time. Despite the promise of scribes, few studies have investigated their effect on clinical encounters, particularly with regard to patient-provider communication.

OBJECTIVE

The purpose of this quasi-experimental pilot study was to understand how scribes affect patient-physician communication in primary care clinical encounters.

METHODS

We employed a convergent mixed methods design and included a sample of three physician-scribe pairs and 34 patients. Patients’ clinical encounters were randomly assigned to a scribe or nonscribe group. We conducted patient surveys focused on perceptions of patient-provider communication and satisfaction with encounters, video recorded clinical encounters, and conducted physician interviews about their experiences with scribes.

RESULTS

Overall, the survey results revealed that patients across both arms reported very high satisfaction of communication with their physician, their physician’s use of the EHR, and their care, with very little variability. Video recording analysis supported patient survey data by demonstrating high measures of communication among physicians in both scribed and nonscribed encounters. Furthermore, video recordings revealed that the presence of scribes had very little effect on the clinical encounter.

CONCLUSIONS

From the patient’s perspective, scribes are an acceptable addition to clinical encounters. Although they do not have much impact on patients’ perceptions of satisfaction and their impact on the clinical encounter itself was minimal, their potential to reduce documentation-related burden on physicians is valuable. Physicians noted important issues related to scribes, including important considerations for implementing scribe programs, the role of scribes in patient interactions, how physicians work with scribes, characteristics of good scribes, and the role of scribes in physician workflow.
A longitudial study of private warehouse investment strategies
Authors: Kohn Jonathan W , McGinnis Michael A , Spillan John E
Published: May 2019

This article revisits private warehouse investment decision making, a topic previously examined in 1989 by McGinnis, Kohn, and Myers (1990). Since then there has been a substantial amount of discussion regarding the scope and nature of logistics /supply chain management. In particular the roles of private, contract, and public warehousing has been discussed, increased emphasis on financial performance and strategic decision making may have altered the criteria for investment decisions in private warehousing, increased coordination of supply chains may have altered the relative importance of private, contract, and private warehousing, and increasing emphasis on controlling inventory investment may have shifted inventory responsibilities onto suppliers and customers. Empirical data was collected in 1999and 2008 regarding warehouse investment decisions in large United State manufacturing firms. This research focused on private warehouse investment decisions, topics that might affect those decisions, and the mix of private, contract, public, and other warehouse options. The results of the 1999 and 2008 data were compared to the earlier findings reported by McGinnis, Kohn, and Myers. Changes in private warehouse investment strategies, the roles of market /product mix uncertainties and availability of for-hire warehouse providers, and changes in warehouse mix were examined. Implications for practitioners, teachers, and researchers of transportation, supply chain management, logistics, and warehousing are discussed.
Developing reverse logistics programs: A resource based view
Authors: Genchev Stephen E , Landry Timothy D , Daugherty Patrica J , Roath Anthony S
Published: May 2019

Previous research proposes a six-process model for reverse logistics (RL) program design and execution. This manuscript advances RL related knowledge by incorporating the previous model into a broader theoretical framework, namely, the Resource Based View (RBV) of the firm. The current research employs exploratory techniques to investigate the applicability of RBV and its main tenants within the RL context. Based on in-depth interviews with 16 executives from seven different companies, the relationships among resources. RL capabilities, and RL competencies are explored.
Fuel costs and supply chain decisions
Authors: Welborn Cliff
Published: May 2019

The affect of rising fuel costs on the individual consumer is well documented in current media. Consumers are paying more for their basic necessities. Fuel surcharge, transportation cost, and logistics have become house hold words. The rising cost of crude oil creates an increase in fuel cost, and this creates an increase in the cost to transport products from one location to another. Managers, who are responsible for acquiring products and delivering them to customers, are also feeling the impact of higher fuel prices. This article will outline three significant areas where fuel prices are affecting U.S. supply chain decisions. Sourcing decisions, transportation modes, and product design and packaging practices are all currently being influenced by the cost of logistics.
EFECTO DE LA PRODUCCIÓN ACUÍCOLA SOBRE LAS VARIABLES DE CALIDAD DEL AGUA DEL LAGO GUAMUEZ
Authors: Imués-Figueroa Marco A. , Gonzalez-Legarda Edgar A. , Duque-Nivia Guillermo , Burbano-Gallardo Elizabeth , Guerrero-Romero Camilo L.
Published: May 2019

La acuicultura es una de las actividades agropecuarias que mayor crecimiento ha mostrado en los últimos años; pero así mismo crece la preocupación por el impacto ambiental que genera en el ambiente. Por lo anterior, la presente investigación se realizó entre los meses de agosto de 2016 y febrero de 2017 en una empresa de cultivo de trucha arcoíris (Onchorhynchus mykiss), ubicada en el Lago Guamuez, evaluando la contaminación que generan dos sistemas de jaulas flotantes (alevinaje y levante y engorde), en comparación con un punto control. Los parámetros fisicoquímicos Oxígeno disuelto, temperatura, conductividad eléctrica, pH, alcalinidad, dureza y transparencia presentaron diferencias significativas (p<0,05) entre las áreas y profundidades de muestreo, al igual que los nutrientes (nitritos, nitratos, fosfatos y fósforo total), donde se presentaron diferencias significativas (p<0,05) entre áreas y sólo en algunas profundidades. Los parámetros fisicoquímicos y los nutrientes demostraron que existe un impacto ambiental en el agua, ocasionado por  los cultivos intensivos de trucha arco iris; sin embargo, los valores obtenidos no representan niveles de contaminación alarmante siendo moderados tanto para los peces de cultivo como para el ecosistema del Lago.

 

Palabras clave: acuicultura, calidad del agua, contaminación del agua, impacto ambiental, trucha arco iris 

ENVIRONMENTAL IMPACT OF INTENSIVE AQUACULTURE IN THE WATER AND SEDIMENT COMPONENTS OF LAKE GUAMUEZ, NARIÑO

ABSTRACT

La acuicultura es una de las actividades agropecuarias que mayor crecimiento ha mostrado en los últimos años; pero así mismo crece la preocupación por el impacto ambiental que genera en el ambiente. Por lo anterior, la presente investigación se realizó entre los meses de agosto de 2016 y febrero de 2017 en una empresa de cultivo de trucha arcoíris (Onchorhynchus mykiss), ubicada en el Lago Guamuez, evaluando la contaminación que generan dos sistemas de jaulas flotantes (alevinaje y levante y engorde), en comparación con un punto control. Los parámetros fisicoquímicos Oxígeno disuelto, temperatura, conductividad eléctrica, pH, alcalinidad, dureza y transparencia presentaron diferencias significativas (p<0,05) entre las áreas y profundidades de muestreo, al igual que los nutrientes (nitritos, nitratos, fosfatos y fósforo total), donde se presentaron diferencias significativas (p<0,05) entre áreas y sólo en algunas profundidades. Los parámetros fisicoquímicos y los nutrientes demostraron que existe un impacto ambiental en el agua, ocasionado por  los cultivos intensivos de trucha arco iris; sin embargo, los valores obtenidos no representan niveles de contaminación alarmante siendo moderados tanto para los peces de cultivo como para el ecosistema del Lago.
X-RAY THERAPY OF TUMORS AND NON-NEOPLASTIC DISEASES
Authors: Editorial Article
Published: May 2019

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MOLECULAR IMAGING
Authors: Editorial Article
Published: May 2019

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INTERVENTIONAL RADIOLOGY
Authors: Editorial Article
Published: May 2019

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PEDIATRIC RADIOLOGY
Authors: Editorial Article
Published: May 2019

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GASRTROINTESTINAL RADIOLOGY
Authors: Editorial Article
Published: May 2019

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Effect of the Ser638Arg variation in the cast gene and causal SNP g.1843C>T in the RYR1 gene on carcass traits in crosbreed pigs
Authors: Vehovský Karel , Zadinová Kateřina , Stupka Roman , Cítek Jaroslav , Okrouhlá Monika , Lebedová Nicole , Sprysl Michal
Published: May 2019

The objectives of this investigation was to demonstrate that genotypes of
calpastatin (CAST) Ser368Arg and ryadonide receptor 1 (RYR1) g.1843C>T may
affect the carcass traits of pigs. Association analysis of the
aforementioned SNPs was performed on 518 pigs included eight commercial
crossbreeds and one pure pig breed. All pigs were slaughtered at average
body weight of 113kg. Genotypes at the SNPs were determined by PCR-RFLP.
There were found only two genotypes of RYR1 gene: CC (428 pigs) and CT (90
pigs) in this study. The effect of allele C compared to allele T on the
higher fat content of pig carcass was confirmed. The allelic frequencies of
allele 638Ser (C) and allele 638Arg (A) were 0.26 and 0.74, respectively.
The significant association (P<0.05) was occurred between allele A and
higher fat content, and between C allele and higher lean meat content. Our
results showed no significant effect of the observed polymorphismSer638Arg
on the intramuscular fat content or other indicators of carcass value.
Fetal chromosomal anomalies in southeast Serbia - single center cohort retrospective study
Authors: Milicevic Radovan , Brankovic Ljiljana , Radulovic Desanka , Jugovic Dragana , Stamenkovic Hristina , Stankovic Tatjana , Milicevic Aleksandar , Madic Visnja , Ristic Marina
Published: May 2019

Congenital anomalies are the cause of prenatal death in 20-25% of the cases,
while 3% of children are born with a malformation of varying size. Many of
these anomalies can be detected before birth using different non-invasive
and invasive prenatal diagnostic tests. This study was used to determine the
distribution of genetic disorders in relation to the age of the mother, the
frequency of aberrations and to study the effects and importance of prenatal
diagnosis in South Serbia. Prenatal diagnostics was performed at the
Pediatric Clinic within the Clinical Center of Nis. This retrospective study
included a group of 8830 pregnant women, aged between 18 and 47 years during
the period from 2004 to 2017. Amniocentesis was performed between the 16th
and 18th week of pregnancy and involved the aspiration of 20 ml of amniotic
fluid. Isolated cells were cultured in a medium that stimulates cell growth
for 10 days. After cytogenetic processing, the obtained karyotype was
analyzed using G-banding techniques. In 8830 samples of amniotic fluid cell
cultures, 198 karyotypes with chromosomal aberrations were found - 179 with
numerical aberrations and 19 with structural aberrations such as
translocations, inversions and deletions. There were 85 karyotypes with
autosomal numerical aberrations and 32 karyotypes with sex chromosome
numerical aberrations. The most frequent one was trisomy 21 (106 cases). The
highest number of autosomal numerical aberrations, 84%, was found in
pregnancies where maternal age was above 30 years. Preventive action,
advice, education and availability of prenatal diagnosis can lead to a
significant reduction in the number of children born with various
malformations.
Heterosis, combining ability and gene action studies in cucumber for different biotic stresses to develope resistant hybrids
Authors: Thakur Manisha , Kumar Ramesh , Kansal Sandeep
Published: May 2019

Biotic stress is the major constrains for the realization of crop yield
potential. As climate change progresses, the spread and intensity of biotic
stress is expected to increase, with increased probability of crops being
exposed to stress. Shielding crops from stress requires a better
understanding of the plant?s response and its genetic architecture. The
dearth of research pertaining to the heterosis, combining ability and gene
action studies for insect-pest (fruit fly) and disease incidences (powdery
and downy mildew) in cucumber compels us to undertake this study. The
experimental material comprised 15 F1 crosses, developed by crossing 6
genotypes during the year 2015. Parents and the 15 hybrids, along with
standard check (KH-1), were planted in a randomized complete block design
during the year 2016 for screening against different insect-pest and
diseases under natural field conditions. In the present studies, genotypes
PI-618860, UHF-CUC-1, UHF-CUC-2 and Khira-75 and crosses Khira-75 x
PI-618860, Khira-75 x UHF-CUC-1 and Khira-75 x UHF-CUC-2 were found superior
in response to insect-pest and disease incidences. Further, gene action
studies indicated predominant role of non-additive gene action governing all
the traits under study.
Preliminary findings of cryptic diversity of the giant tiger shrimp (Penaeus monodon Fabricius, 1798) in Indonesia inferred from COI mitochondrial DNA
Authors: Yudhistira Amri , Arisuryanti dan
Published: May 2019

This study investigated genetic diversity of the giant tiger shrimp (Penaeus
monodon), an economically important penaeid species in Indonesia, using 558
base pairs of the mitochondrial cytochrome c oxidase Subunit I (COI) gene. A
total of 10 samples were collected from three populations throughout
Indonesia and three samples were taken from hatchery. The mitochondrial COI
results found high levels of genetic differentiation. From Bayesian tree
building method there were two clades on phylogenetic tree with high
posterior probability value 1.00. COI mt-DNA analyses revealed that there
were six haplotypes in which four haplotypes in clade A and two haplotypes
in clade B. Divergences of COI between two clades showed an average 6.9%
(range=6.7%-7.6%), while genetic distance within clade A 0.2% (range=0-0.5%)
and within clade B 0.3% (range=0-1.1%). Results from this study suggest the
occurrence of two cryptic species in the Penaeus monodon from Indonesia.
Comparative biological characteristic of white lupin (Lupinus albus L.) varieties
Authors: Kosev Valentin , Vasileva Viliana
Published: May 2019

The study was conducted in 2014-2016 on the experimental field of the
Institute of Forage Crops, Pleven, Bulgaria. Aboveground and root biomass
plant material of seven white lupin (Lupinus albus L.) varieties different
originated was analyzed in two phenological stages. Plants were analyzed for
height, fresh weight, number of leaves, nodule number and nodule weight in
the beginning of flowering stage, and for number of pods, number of seeds
and seed weight in the technical maturity stage. Degree of earliness of
varieties was assessing as well. The group of ultra early varieties can be
defined PI533704 and Zuter varieties with coefficient of earliness 1.00, to
early - PI368911, PI457938 and KALI (coefficient of earliness 1.25), and to
late Lucky801 and PI457923 (coefficient of earliness >1.66). A strong
positive correlation was found between the seed productivity with number of
seeds per plant (r=0.943) and plant height (r=0.765); close relationship of
fresh aboveground mass weight with plant height (r=0.822), number of leaves
(r=0.965) and fresh root mass weight (r=0.876). The varieties of interest
for breeding were selected by different signs. It was concluded that the
number and weight of nodules as well fresh root mass weight can be used as
selection criteria for creating varieties with a higher symbiotic nitrogen
fixation potential.
Evaluation of protective effects of propolis against aluminium silicate toxicity in rats
Authors: Abd El-Aziz , Abu-Almaaty Ali , Omar Nahed , Abdeen Ahmed , Zakaria Mahmmoud
Published: May 2019

Objective of the study was evaluation of the harmful effect induced by
aluminum silicate in bone marrow chromosomes and liver tissues. Also, how
could prevents this toxicity. 60 Adult male albino rats weighing 100-120 g
were used for our experiments. The animals were divided into six equal
groups: first normal healthy control group, second group was given 200 ml
propolis/Kg day after day by stomach gavage, third group received low dose
of aluminum silicate (5 mg/kg; intra peritoneal) twice a week, forth group
injected with high dose of aluminum silicate (20 mg/kg; intra peritoneal)
twice a week, fifth group received propolis and aluminum silicate with
similar doses as that of second & third groups and sixth group received
propolis and aluminum silicate with similar doses as that of second & forth
groups. At the end of 8 weeks for each rat, bone marrow was aspirated and
liver was removed for lab examinations. The results showed that rats exposed
to aluminum silicate had severe chromosomal aberrations and changes in CYP
gene expression. It caused significantly increased in the frequency of
chromosomal aberrations such as polyploidy, hypoploidy, deletions,
fragments, chromatid breaks, chromosome breaks, double minutes, ring, gap
and translocation were also observed. Gene expression of CYPs was increased
with exposure to aluminum silicate and was down regulated in treatment with
propolis while Bcl-2 and BAX were decreased in exposure to aluminum silicate
and up regulated by the treatment. Propolis has a curative effect against
aluminum silicate toxicity owing to its antioxidant property.