bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of entanglement via a multi-agent dynamical quantum game
Authors: Te’eni Amit , Peled Bar Y. , Cohen Eliahu , Carmi Avishy
Published: January 2023

At both conceptual and applied levels, quantum physics provides new opportunities as well as fundamental limitations. We hypothetically ask whether quantum games inspired by population dynamics can benefit from unique features of quantum mechanics such as entanglement and nonlocality. For doing so, we extend quantum game theory and demonstrate that in certain models inspired by ecological systems where several predators feed on the same prey, the strength of quantum entanglement between the various species has a profound effect on the asymptotic behavior of the system. For example, if there are sufficiently many predator species who are all equally correlated with their prey, they are all driven to extinction. Our results are derived in two ways: by analyzing the asymptotic dynamics of the system, and also by modeling the system as a quantum correlation network. The latter approach enables us to apply various tools from classical network theory in the above quantum scenarios. Several generalizations and applications are discussed.
Effectiveness of tailored COVID-19 messages for vulnerable Australians: A study protocol
Authors: Jepson Megan , Williams Nathan , Haines Terry P. ,   on behalf of the PIVC (Pandemic Information for Vulnerable Communities) Group
Published: January 2023

Multiple approaches can be used to communicate public health messages through mass media. It is unclear which approaches are superior for meeting the needs of the general community along with vulnerable population subgroups. To compare different public health strategy communication approaches for influencing the COVID-safe behavioural intentions of both community and vulnerable population subgroups. This study will conduct three concurrent ‘helix’ randomised controlled trials with Latin square sequencing and factorial intervention allocation to assess the effectiveness of different communication strategies amongst the Australian general community and six subgroups that are considered vulnerable to contracting, transmitting or experiencing severe consequences of COVID-19 infection. Communication approaches being compared include: the format of communication (written versus video), who is providing information (general practitioner, politician, community-representative), what is said and how it is delivered (direct information provision versus conversational approach) and the visual content of video messaging (animation versus ‘talking head’). Recruited participants will be randomly allocated to receive a specific combination of health messaging strategies using six different COVID-19 context areas. Outcomes will be assessed in a survey using behaviour intention questions, and questions surrounding level of agreement with feeling represented in the health messaging strategy. These trials will use a unique research approach to provide an experimental evidence base to help guide development of impactful and inclusive COVID-19 and related public health messaging. All three trials are registered with the Australian New Zealand Clinical Trials Registry (ANZCTR). Trial 1: Update and impact of Government recommendations about COVID-19 (coronavirus)-Stage 3, Trial 1, vulnerable subgroup populations (ACTRN12622000606785). Trial 2: Update and impact of Government recommendations about COVID-19 (coronavirus)-Stage 3, Trial 2, community group (ACTRN12622000605796). Trial 3: Update and impact of Government recommendations about COVID-19 (coronavirus)-Stage 3, Trial 3, What communication strategy is most effective for both vulnerable and community group populations? (ACTRN12622000617763).
Is Fibersol-2 efficacious in reducing duration of watery diarrhea and stool output in children 1–3 years old? A randomized, parallel, double-blinded, placebo-controlled, two arm clinical trial
Authors: Shahid Abu Sadat Mohammad Sayeem Bin , Ahmed Shahnawaz , Dash Sampa , Kishimoto Yuka , Kanahori Sumiko , Ahmed Tahmeed , Faruque Abu Syed Golam , Chisti Mohammod Jobayer
Published: January 2023

Background

Fibersol-2 has innumerable beneficial effects on human health. It is a fermentable, non-viscous, water-soluble, indigestible dextrin containing 90% dietary fiber produced from corn starch. We aimed to evaluate whether additional intake of Fibersol-2 along with oral rehydration solution treatment can reduce the duration of watery diarrhea and daily stool output in children 1–3 years as well as recovery of such children within 72 hours, compared to placebo.

Methods

This placebo-controlled double-blinded, randomized parallel two arm trial conducted in Kumudini Women’s Medical College Hospital in rural Bangladesh between March and October, 2018 used 5 gm of either Fibersol-2 or placebo dissolved in 50-ml drinking water which was given orally to ninety-two children with watery diarrhea on enrollment twice daily for a period of 7 days. Randomization was done using a randomization table. We randomly allocated 45 (49%) and 47 (51%) children in Fibersol-2 and placebo groups, respectively. Outcome measures were duration of resolution of watery diarrhea, daily stool output and the proportion of children recovered within 72 hours. Primary and safety analyses were by intention to treat. This trial was registered at ClinicalTrials.gov, number NCT03565393.

Results

There was no significant difference observed in terms of duration of resolution of diarrhea (adjusted mean difference 8.20, 95% CI -2.74 to 19.15, p = 0.14, adjusted effect size 0.03); the daily stool output (adjusted mean difference 73.57, 95% CI -94.17 to 241.32, p = 0.38, adjusted effect size 0.33) and the proportion of children recovered within 72 hours (adjusted odds ratio 0.49, 95% CI = 0.12 to 1.96, p = 0.31, adjusted risk difference -0.06 (95% CI -0.19 to -0.06), after regression analysis between Fibersol-2 and placebo.

Conclusion

No beneficial role of Fibersol-2 was observed in diarrheal children aged 1–3 years.

Trial registration

This trial is registered at ClinicalTrials.gov, number NCT03565393. The authors confirmed that all ongoing and related trials for this drug/intervention are registered. https://clinicaltrials.gov/ct2/show/NCT03565393.
Cross-linguistic conditions on word length
Authors: Wichmann Søren , Holman Eric W.
Published: January 2023

Based on a dataset representing close to ¾ of the world’s languages we investigate differences among languages and between items on the Swadesh list with regard to mean word length from a linguistic typological point of view. Mapping the world-wide distribution of word length shows convergence at a continent-wide level, a Pacific Rim signature, and a tendency for large word length averages to be a recessive trait. The amount of data, which is unparalleled in previous, related studies, allows us to provide more solid estimates and accounts for the interrelationships between word length, phoneme segment inventory size, and population size than was previously possible. Word length differences between items exhibit robust, universal tendencies, which are discussed in relation to other quantities, including stability, synonymy, and attestation.
Genome destabilization-associated phenotypes arising as a consequence of therapeutic treatment are suppressed by Olaparib
Authors: Suzuki Mafuka , Fujimori Haruka , Wakatsuki Kakeru , Manaka Yuya , Asai Haruka , Hyodo Mai , Matsuno Yusuke , Kusumoto-Matsuo Rika , Shiroishi Mitsunori , Yoshioka Ken-ichi
Published: January 2023

Malignancy is often associated with therapeutic resistance and metastasis, usually arising after therapeutic treatment. These include radio- and chemo-therapies, which cause cancer cell death by inducing DNA double strand breaks (DSBs). However, it is still unclear how resistance to these DSBs is induced and whether it can be suppressed. Here, we show that DSBs induced by camptothecin (CPT) and radiation jeopardize genome stability in surviving cancer cells, ultimately leading to the development of resistance. Further, we show that cytosolic DNA, accumulating as a consequence of genomic destabilization, leads to increased cGAS/STING-pathway activation and, ultimately, increased cell migration, a precursor of metastasis. Interestingly, these genomic destabilization-associated phenotypes were suppressed by the PARP inhibitor Olaparib. Recognition of DSBs by Rad51 and genomic destabilization were largely reduced by Olaparib, while the DNA damage response and cancer cell death were effectively increased. Thus, Olaparib decreases the risk of therapeutic resistance and cell migration of cells that survive radio- and CPT-treatments.
A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency
Authors: Hsieh Emily , Janssens Derek H. , Paddison Patrick J. , Browne Edward P. , Henikoff Steve , OhAinle Molly , Emerman Michael
Published: January 2023

Transcriptional silencing of latent HIV-1 proviruses entails complex and overlapping mechanisms that pose a major barrier to in vivo elimination of HIV-1. We developed a new latency CRISPR screening strategy, called Latency HIV-CRISPR which uses the packaging of guideRNA-encoding lentiviral vector genomes into the supernatant of budding virions as a direct readout of factors involved in the maintenance of HIV-1 latency. We developed a custom guideRNA library targeting epigenetic regulatory genes and paired the screen with and without a latency reversal agent–AZD5582, an activator of the non-canonical NFκB pathway–to examine a combination of mechanisms controlling HIV-1 latency. A component of the Nucleosome Acetyltransferase of H4 histone acetylation (NuA4 HAT) complex, ING3, acts in concert with AZD5582 to activate proviruses in J-Lat cell lines and in a primary CD4+ T cell model of HIV-1 latency. We found that the knockout of ING3 reduces acetylation of the H4 histone tail and BRD4 occupancy on the HIV-1 LTR. However, the combination of ING3 knockout accompanied with the activation of the non-canonical NFκB pathway via AZD5582 resulted in a dramatic increase in initiation and elongation of RNA Polymerase II on the HIV-1 provirus in a manner that is nearly unique among all cellular promoters.
Tendencias recientes del turismo de cruceros en el Atlántico Occidental Ibérico, un estudio de caso
Authors: Patiño Romarís Carlos Alberto , López González Alejandro , Lois González Rubén Camilo
Published: January 2023

El turismo de cruceros representa el segmento del mercado turístico internacional que mayor crecimiento ha experimentado en las últimas décadas. Una realidad que ha llevado a que las Administraciones Públicas lo cataloguen como un producto clave. Este trabajo de investigación tiene como objetivo analizar la competitividad territorial en el turismo de cruceros de los puertos localizados en el ámbito del Atlántico occidental Ibérico. Mediante un análisis de carácter empírico, basado en la aplicación de técnicas de regresión de panel, dibujamos la realidad territorial de los puertos de este espacio geográfico a la hora de atraer cruceros turísticos a sus instalaciones. Un análisis que nos habla de crecimiento y de menor competitividad de los puertos gallegos con respecto a los puertos de Leixões y Lisboa que confluyen en el mismo espacio marítimo.
Análisis de ejecución de los planes de renovación de destinos turísticos de litoral. El caso de Puerto de la Cruz (Canarias, España)
Authors: Ledesma González Oswaldo , García Cruz Juan Israel , Hernández Hernández Jesús
Published: January 2023

La política turística implementa sus acciones a través de un conjunto de instrumentos cuya configuración y ejecución son esenciales en la acción del gobierno, convirtiéndose en un indicador fundamental para evaluar su enfoque y efectos. En lo que respecta a la renovación de los destinos turísticos, la política turística de Canarias ha diseñado los Planes de Modernización, Mejora e Incremento de la Competitividad entre sus instrumentos más importantes, concentrando en ellos un significativo conjunto de medidas. En este contexto, el presente trabajo se centra en cómo se ha configurado y ejecutado este instrumento, tomando como caso de estudio el plan implementado en Puerto de la Cruz. El análisis se desarrolla sobre las acciones de renovación del espacio público y privado, llevando a cabo un proceso metodológico basado en el análisis de contenido y entrevistas no estructuradas con actores clave.
La ciudad histórica como destino turístico inteligente. El caso de Segovia, ciudad patrimonio mundial
Authors: Calle Lamelas Juan Vicente , García Hernández María , García Muiña Fernando Enrique
Published: January 2023

Las Ciudades Patrimonio de la Humanidad son destinos turísticos de larga tradición y una alta afluencia de visitantes. Por otra parte, el “Destino Turístico Inteligente” (DTI) se ha erigido como un nuevo paradigma de gestión turística auspiciado por la administración turística en España. En este contexto, el presente artículo tiene como objetivo profundizar en el conocimiento e interpretación del modelo DTI que atesoran los grupos de interés de un destino Patrimonio de la Humanidad. Para ello se toma la ciudad de Segovia como estudio de caso. Se han realizado un total de 28 entrevistas semiestructuradas a actores de la ciudad y expertos en el modelo DTI. Los resultados obtenidos muestran la necesidad de adoptar un enfoque de abajo-arriba, que desarrolle el capital humano y una orientación más estratégica. Se propone además un modelo de actuación basado en los temas centrales identificados por los grupos de interés.
Málaga: Urbanismo, Turismo y Patrimonio. Daniel Barrera Fernández. Tirant Humanidades. 2021
Authors: Teran Cordova Geomara Berenice
Published: January 2023

El presente libro ofrece una investigación detallada sobre el origen, los factores y el desarrollo del turismo en Málaga, llevada a cabo por el arquitecto y profesor de la Universidad de Sevilla, Daniel Barrera Fernández. La ciudad de Málaga ha vivido un intenso proceso de transformación urbana para fomentar el turismo cultural, un fenómeno compartido con numerosos destinos europeos en las últimas dos décadas. Sin embargo, el turismo cultural urbano no es un fenómeno reciente, sino que cuenta con hondas raíces en el Grand Tour (López Martínez, 2015). El turismo cultural en ámbitos urbanos es visto como una forma de diversificar la economía local en contextos de incertidumbre. Por otra parte, sirve para desestacionalizar entornos urbanos con una manifiesta masificación turística. Algunos ejemplos en este sentido son Bilbao(Caparrós i Gironés,2019) Praga (Dumbrovská,2017). No obstante, el turismo cultural urbano actual también es causante de saturación turística. El caso de Málaga supone un caso ejemplar en el que se evidencian los fenómenos enunciados (Marín Cots et al., 2017). ISBN: 9788418656088.
The Expansion of Qualitative Research Methods in Innovation Policy Studies
Authors: Wibisono Eristian
Published: January 2023

Abstract

This paper intends to provide a general description of the position of a qualitative approach in the study of innovation policy and its possible expansion based on the experiences of experts from other disciplines. There is an important and urgent matter about improving young researchers' methodological skills in understanding complex innovation studies. By understanding and mastering various methodological skills, individual researchers, groups, or innovation study communities can provide comprehensive interpretations and insights from unit analysis to draw accurate conclusions in response to phenomena and planned research questions. Some of the research approaches suggested in this paper, namely ethnographic research and action research, require additional research skills in the field. The ethnographic approach and the participant approach allow young researchers to influence the research design by involving participants in the research in a planned manner. Therefore, it is appropriate to use a participatory approach as methodological enrichment in innovation studies. An ethnographic approach will benefit from the perspective of the innovation policy group. The qualitative approach described in this paper can be used in mixed methods, along with quantitative methods.

 
Keywords: qualitative methods, mixed-methods, innovation, policy studies
Challenges and Barriers in Public Services Innovations in Malaysia
Authors: Yusof Nor Ashikin Mohamed , Rafee Salwa Ahmad , Ishak Aspah Aini , Razali Muhammad Rohaizad , Saimy Intan Sazrina
Published: January 2023

For the last two decades, the government of Malaysia has been moving away from the traditional roles of managing, governing and providing services for the country. The government is actively encouraging the public or civil servants to join the bandwagon and create innovations in the course of their works, protect their innovations with intellectual property protection and whenever possible commercialize them. Such a giant leap is in line with the provisions of Science, Technology and Innovation Policy 2020 in the efforts of converting Malaysian’s economy from manufacturing-based to knowledge and innovation-based instead. It also provides is a good opportunity for the government to create a new source of financial and economic income, save resources and increase the intellectual property index and ranking globally. A lot of incentives, resources and supports were re-channeled for that purpose. To date, the implementation, real outcomes, outputs and impacts of the government’s servant in the innovative activities remain largely unmeasured. Whether the return of investment for such undertakings is commensurate with the efforts or otherwise. What happens to the “innovators” and their inventions are untraced. This paper presents part findings on Malaysian’s experiences towards creating innovations and fulfilling the STI Policy’s objectives. The article focuses on the civil servants’ involvement in developing or creating innovative products or services and their challenges in materializing that policy objective. The study was conducted amongst public servants. Primary data was collected through interviews and focus group discussions with the winning organizations or units of the National Award for Public Sector Innovations. In total, 86 participants from four winning organizations were involved. The civil servants’ efforts are commendable and encouraging. This shows the objectives of the STI Policy are correct. Secondly, the strategies of the STI Policy are only workable if they are supported with a correct support system and well-designed implementation plan or programs, The result also shows that the STI Policy document is broad-ranging, inclusive and unlimited for private sectors, big companies or intended for machines, engineering or hardware only. It includes public sector as well as “soft” innovations in terms of service and management processes, produced by the civil servants are equally valuable, useful and should not be disregarded. However, the government must iron out few challenges in ensuring the innovation program for civil servants are sustainable. The findings of this paper are useful as policy input in improving the support systems, designing action plans or policy interventions for STI Policy in the future.

 

Keywords: public sector innovation, service innovation, National Science Technology and Innovation Policy 2013-2020
Instituto da Delação Premiada e a Teoria dos Jogos no Processo Penal Brasileiro
Authors: Cordazzo Karine , De Santana Santos Cíntia
Published: January 2023

O presente trabalho pretende abordar o instituto da delação premiada, fazendo uma breve análise no ordenamento jurídico brasileiro quanto a sua previsão, considerando especificamente o que diz respeito à suas características sob a ótica da teoria dos jogos no Processo Penal Brasileiro. Considerando a sua evolução até os dias atuais, demonstrando suas aplicabilidades e expansão. A partir de então, destacando que, embora sofra inúmeras criticas é um instituto que vem exercendo um papel importante para desnudar crimes e criminosos de maneira dinâmica, minimizando os impactos negativos que a criminalidade causa a sociedade, almejando alcançar seu desmantelamento, para que sejam descobertos, investigados e punidos
Estabilização da Tutela Provisória de Urgência Antecipada Antecedente e os Recentes Entendimentos do Superior Tribunal de Justiça
Authors: Zielinski Georgia , Minotto Gomes Schwertner Isadora
Published: January 2023

A pesquisa busca analisar as tutelas provisórias e suas modalidades como instrumentos do processo civil, observada a função constitucional do processo. Possui também como objetivo central a análise do procedimento legal de estabilização da tutela provisória antecipada concedida de maneira antecedente e os meios para evitar a estabilização, observados os princípios constitucionais. À vista disso, levantaram-se referências bibliográficas acerca do tema, passeando pelos conceitos de tutela provisória, tutela provisória de evidência, tutela provisória de urgência cautelar e tutela provisória de urgência antecipada, bem como a hipótese de cabimento e o procedimento de estabilização. Particularmente, o procedimento da estabilização é estudado conforme definição do artigo 304 do Código de Processo Civil e pelas interpretações deste dispositivo legal pelo Superior Tribunal de Justiça até o momento. Assim, evidenciam-se divergências de entendimento sobre a concretização e o rito do instituto de estabilização entre a Terceira Turma do Superior Tribunal de Justiça ao julgar o recurso especial nº 1.760.966-SP e a Primeira Turma ao julgar o recurso especial nº 1.797.365-RS. Ao final, conclui-se pela defesa da interpretação literal do dispositivo como procedimento legal cabível, em respeito ao aspecto constitucional do processo e à vontade do legislador.
Efetividade da Guarda Compartilhada Obrigatória como Prevenção da Alienação Parental
Authors: De Magalhães Souza Ionete , Rielli Silveira D'Angeles Mendes Juliana
Published: January 2023

O presente artigo tem como tema a efetividade da guarda compartilhada obrigatória como prevenção da alienação parental. A temática é relevante, tendo em vista a tardia formalização desses institutos no ordenamento brasileiro, bem como o alto número de litígios entre genitores acerca da guarda dos filhos, do que pode decorrer a alienação parental. Portanto, a pesquisa tem por escopo responder ao seguinte questionamento: a guarda compartilhada obrigatória é eficaz para prevenir a alienação parental? Objetiva-se, de forma geral analisar a efetividade da obrigatoriedade da guarda compartilhada como prevenção da alienação parental. Especificamente, aborda-se o tema a partir da noção histórica de família, com delineação do seu conceito; discorre-se sobre poder familiar; analisa-se a doutrina da proteção integral, que se desdobra nos princípios do melhor interesse da criança, da prioridade, do cuidado e da afetividade; examina-se a dissolução das entidades familiares; especificam-se as modalidades de guarda existentes no ordenamento; examina-se a instituição da obrigatoriedade da guarda compartilhada; discorre-se sobre a alienação parental, nos moldes de Lei no 12.318/2010. Realiza-se uma pesquisa qualitativa, exploratória, bibliográfica, documental, histórica e jurisprudencial. Ainda, utiliza-se do método de abordagem dedutivo e do método de procedimento monográfico. A guarda compartilhada obrigatória enseja o diálogo e o respeito entre os genitores, porquanto fomenta o acompanhamento multiprofissional, de forma que os problemas advindos do rompimento do vínculo conjugal não afetem o relacionamento com os filhos. Portanto, conclui-se que a guarda compartilhada obrigatória é instrumento eficaz de prevenção da alienação parental.
Apontamentos sobre a Subcidadania da População Carcerária Versus Reinserção pela Atividade Laboral
Authors: Fernandes Fábio Luis , Evaristo Wenceslau Maurinice
Published: January 2023

Este artigo tem como objetivo analisar a construção de um modelo ideal de indivíduo dentro da economia de mercado, promovido pela universalização de um conceito de cidadania legitimado e justificado pela meritocracia. Para tanto, trabalhamos com a hipótese de que em um país marcado por desigualdades sociais como o Brasil, o surgimento de subcidadãos toma forma na marginalização da proteção garantida pela dignidade humana e, diante disso, sujeitos a constante discriminação. No interior desta condição de subcidadão, priorizamos estudos sobre a população carcerária e a atividade laboral configurada no instrumento de reinserção, ao mesmo tempo, que orientador da construção de uma consciência cidadã entre os detentos, para que consigam entender seu papel no corpo social. Neste contexto, utiliza-se da pesquisa bibliográfica como forma de dar nova visão a pesquisas já realizadas sobre o tema. Por fim, o cerne da discussão da subcidadania e da essencialização ancoram-se na percepção de que as diferenciações sociais, de classe e de trabalho, precisam transformar os fenômenos apreendidos como rotineiros do mundo material, a partir da compreensão de que cada pessoa deve ser respeitada em razão da dignidade que lhe é inerente, como valor absoluto que o ser humano possui por se constituir em um fim em si mesmo e não em um meio.
Right of Data Portability in EU’s GDPR and Brazil’s LGPD
Authors: Copetti Cravo Daniela
Published: January 2023

At the same time that data portability is one of the greatest innovations brought by contemporary data protection legislation, it also represents one of the market’s greatest challenges. Concerns about data transmission or interoperability safety are inevitable, as well as about compliance costs. Thus, innumerable doubts arise regarding the aspects of data portability implementation and its peculiarities. In this sense, the paper aims to analyse the most critical points of data portability in the Brazilian context based on comparisons of other legal systems experience, especially that of the European Union.
Desafios contemporâneos do direito à prova
Authors: Ritzmann Torres Paula
Published: January 2023

O presente artigo expõe criticamente alguns aspectos relacionados às formas de obtenção de dados digitais (armazenados em dispositivos físicos e em nuvens) localizados fora do território de um Estado para fins penais. Abordam-se os impactos da realização da cooperação jurídica internacional e da fixação de jurisdição de execução em relação aos meios de obtenção de prova voltados para a obtenção dos dados digitais localizados no exterior, levando em consideração não somente os interesses dos Estados, mas também os direitos humanos dos indivíduos envolvidos.
violação dos direitos humanos em virtude de restrições e banimento virtual por parte de plataformas privadas
Authors: Santana Gonçalves Carla , Cavalcante Ribeiro Luiza , Da Silva Moura Junior Carlos Alberto
Published: January 2023

Esse trabalho possui como objetivo analisar o poder que as três gigantes da internet (Facebook, Twitter e Google) possuem de controlar o direito a comunicação dos seus usuários, limitando a sua liberdade de expressão, principalmente através da exclusão das contas que violam as diretrizes internas dessas plataformas. A questão principal é se os CEO`s dessas empresas podem tomar decisões tão duras, as quais são capazes de restringir um dos pilares do sistema democrático, com base unicamente em suas políticas privadas, sem seguir nenhuma lei? Para tentar chegar a uma resposta será analisado o banimento do ex-presidente americano Donald Trump e as opiniões de diversas autoridades sobre esse caso. Para tanto nos basearemos em uma pesquisa documental. Conclui-se, portanto, que uma decisão que é tomada pautada em cunhos ideológicos, apesar de alegrarem e satisfazerem uma parcela social, em verdade, quando se analisa sua essência, percebe-se a afronta e retirada e descarte da garantia de direitos para a sociedade como um todo.
PHARMACEUTICAL AND LEGAL ISSUES OF PRODUCTION AND THE USE OF INFUSIONS IN ANESTHESIOLOGY (FOR EXAMPLE, CARDIOPLEGIC SOLUTIONS)
Authors: Ovod A. I. , Novikova M. D. , Simonyan R. Z.
Published: January 2023

The use of various infusion solutions in anesthesiology and intensive care involves certain risks due to the complexity of the supervised cases and the uniqueness of the interventions. Nevertheless, today reliable principles and approaches have been developed at the state level to minimize the threats associated with the quality of infusion solutions. These include the requirements for mandatory registration of all new combined solutions, including those made from already known components, as well as the rules for the production of sterile infusions according to the standard of good manufacturing practice (GMP – good manufacturing practice). Mandatory compliance with these requirements is a guarantee of the safety of infusion therapy from the standpoint of the quality of the infusion solution that is injected into the patient՚s body.
On the example of cardioplegic solutions, the safety problems and contradictions in the existing system of providing high-tech field of medicine – cardiac surgery are shown.
Orgasmos Musicais e Revolução Cultural em América do Sexo (1969)
Authors: Pereira da Costa Júnior Francisco José
Published: January 2023

América do Sexo, filme de 1969, foi censurado pela ditadura militar brasileira (1964-1985) por aproximadamente dez anos e depois de sua liberação não teve um lançamento oficial. Sua circulação foi e continua sendo extremamente restrita, permanecendo um objeto cinematográfico obscuro, inclusive em estudos aprofundados sobre o cinema experimental no Brasil. Este artigo propõe uma escuta da sua trilha musical, analisando como se deu a sua construção e discutindo aspectos culturais, sociais, políticos e ideológicos, organizados por vezes de forma intertextual e que corroboram uma faceta antropofágica do cinema moderno brasileiro.
Prvý oddíl čtrnáctého dodatku Ústavy Spojených států: původní význam a výklad
Authors: Ženíšek Jaroslav
Published: January 2023

The paper analyzes the first section of the Fourteenth Amendment to the United States Constitution and its four key clauses – the citizenship clause, the priviliges or immunities clause, the due process clause and the equal protection clause. Special attention is paid to the debates of the members of the 39th Congress which offer an insight into the original understanding of terms and phrases used in the text of the Amendment and that make possible to understand the context of its origin. The paper tries to describe the most likely original meaning of the individual clauses of the first section and analyze their possible various interpretations that often stand in direct opposition. While it can be reasonably assumed that during the times of the passing and ratification of the Amendment its objective was fairly limited, reflecting the post-war political reality in the United States, during the decades following ratification the Amendment started to be applied to issues that until then had been completely in the hands of the legislatures and depending on the democratic discussion on both federal and state level. The authors quoted in this paper can not be assigned to just one method of interpretation and legal philosophy, to the contrary, the paper aims to confront different views on the Amendment and its original meaning and based on it reach a conclusion; therefore both the view seeing the meaning of the Amendment as limited, held for example by professors Charles Fairman and Raoul Berger, and the perspective that sees its objectives as broader, represented for example by professors Michael Kent Curtis and Randy Barnett, are mentioned.
Anteroom to the Forint: Monetary Law Aspects of the Temporary Period of Issuing Money in Hungary under the Supervision of the Temporary National Government (1944–1945)
Authors: Töreki Milan
Published: January 2023

This study presents the destruction of the Hungarian currency caused by the Second World War. The devastation caused by Nazi collaboration and the Soviet Red Army had an impact on the Hungarian “pengő”. The occupying Soviets tried to take advantage of all this and interfered with the circulation of money to increase their own political influence. They printed their own banknotes, which were later used to pay by the Hungarian National Bank. The Provisional Government tried to stop inflation after the war and then tried to resist Soviet pressure and to restore cash flow in Hungary, as well.
Právnické vzdělávání za socialismu. Kolokvium s pamětníky přibližující fungování Právnické fakulty UJEP v Brně v období socialismu
Authors: Kabát Jan
Published: January 2023

A Colloquium Report
“For the Defense of the Liberties and Independence of the United States”: Remembering a Forgotten Militia Post and Quasi-War Cantonment in Plainfield, New Jersey (Part 2 of 2)
Authors: Radice Ryan
Published: January 2023

The area around Green Brook Park in Plainfield, New Jersey, was the site of two significant military encampments during the revolution and the new nation’s first international conflict, the Quasi-War. This is part two of a two-part article arguing the significance of the site in both conflicts through an analysis of surviving primary-source material. (The first installment was published in the Summer 2022 issue of this journal.) This article concerns the Quasi-War–era cantonment established in Plainfield, known as the Union Camp. Established in October 1799, the Union Camp served as a winter cantonment for three regiments of the “New Army,” raised in anticipation of possible war with France. This article examines the reasons why the New Army’s officers, especially Inspector General Alexander Hamilton, chose to quarter three regiments (known as the Union Brigade) in Plainfield. It also examines the hutting practices used at the Union Camp to shelter the three regiments, and the many ways the men of the New Army both relied on previous experience from the revolution while also innovating. Lastly, it discusses many aspects of life in camp, issues with health and supplies, and the interactions of a controversial army with the local population.
Taking Sides in Revolutionary New Jersey: Caught in the Crossfire
Authors: Lender Mark Edward
Published: January 2023

Mark Edward Lender reviewing Taking Sides in Revolutionary New Jersey: Caught in the Crossfire, by Maxine N. Lurie.
Estilos lingüísticos de mujeres víctimas de violencia intrafamiliar en Colombia
Authors: Carvajal-Builes Juan Camilo , Palacio-Aguirre Lina Yineth , López Cantero Ever José , Medrano Tovar Claudia Marcela
Published: January 2023

Tradicionalmente, a la familia se le han atribuido diversas funciones consideradas universales, tales como: conservación de la especie humana, resguardo, aprendizaje interaccional, regulación de la conducta, determinación del estatus para el niño, manejo y expresión de emociones, entre otras (Pérez & Dugarte, 2011). En el contexto de la familia se crean espacios de socialización que permiten a sus integrantes compartir aptitudes, actitudes, sentimientos y experiencias que son vitales para el desarrollo integral y la interacción con el entorno (Oliva & Villa, 2014). Vanegas y Agudelo (2016) consideran la familia como la célula fundamental de la sociedad, la cual constituye un reflejo de las formas de relacionamiento y la realidad contextual del individuo y la comunidad, lo cual se expresa por medio del lenguaje; por tanto, si dentro del núcleo familiar existen relaciones disfuncionales marcadas por conductas violentas, habrá mayor probabilidad de que se den sesgos cognitivos frente a la percepción de sí mismo y del mundo, provocando deterioro en la estructura y degradando algunos valores morales que conlleven a diversas formas de agresión, de magnitud variable, lo que ha recibido la designación de “violencia doméstica”, “violencia familiar” o “violencia intrafamiliar” (Carbajal et al., 2006).
Relación entre comportamiento visual y desempeño global en pruebas Saber Pro
Authors: Carvajal-Builes Juan Camilo , Ríos-Cruz Sonia Gisela , Romero-Espinosa Olga , Pardo-Adames Carlos Antonio , Garzón-Velandia Diana Camila , Ocampo-Villegas Héctor Balmes , Chacón-Ruiz Jhon Erick , Guanumen Niño Julián David
Published: January 2023

La metodología Eye tracking se utiliza para registrar el comportamiento visual mediante el seguimiento ocular a fin de rastrear: el tamaño y el diámetro de la pupila, el movimiento de los ojos y las fijaciones ante la presencia de un estímulo visual (Van Assendelft, 2017). En términos generales, se emplea una luz infrarroja que ilumina el ojo para captar la luz que pasa por la pupila, luego se refleja de vuelta por la córnea para finalmente proyectarse en un dispositivo (Holmqvist et al., 2017; Miller, 2015; Nilsson & Nivre, 2010). El Eye tracker es el instrumento que permite realizar este registro. Esta metodología se ha utilizado en el estudio de la lectura con el fin de registrar la dirección y detención de los movimientos oculares y determinar así qué área del texto está siendo enfocada durante la lectura (área de interés); por tanto, se constituye en una forma de validez ecológica del proceso cognitivo atencional que subyace a la conducta lectora (Bax & Chan, 2019; Parodi y Julio, 2016).
Teratología conductual: un apasionante campo de trabajo transdisciplinar
Authors: Santacruz-Ortega María del Pilar
Published: January 2023

Desde el impresionante precedente de la tragedia de la Talidomida, un ansiolítico, hipnótico y antiemético usado en el primer trimestre de la gestación que causó graves malformaciones cardíacas, renales, digestivas, oftálmicas auditivas y ausencia total o parcial de los miembros superiores/inferiores, entre otras, y a partir de trabajos como (DeSesso, 2019; Moore & Persaud, 2013; Papaseit et al., 2013), y la publicación del minucioso trabajo de Werboff & Gottlieb (1963) se estableció que las drogas de consumo materno durante la gestación –tanto las prescritas como las que no– tienen unos potentes efectos teratogénicos, es decir, producen malformaciones congénitas durante el desarrollo del infante. Estas malformaciones pueden darse en diferentes órganos o tejidos; y cuando ocurren en el sistema nervioso no son tan evidentes, y se reflejan en alteraciones del comportamiento que se pueden manifestar en la infancia, la adolescencia o más tardíamente. Cuando las malformaciones congénitas se observan en el comportamiento, pertenecen al campo de la Teratología Conductual o Teratología Neuroconductual (Minnes et al., 2014; Werboff & Gottlieb, 1963).
The Power of Coordination and Deliberation
Authors: Monnet Eric
Published: January 2023

I provide comments and replies to the seven insightful contributions that discussed “The Democratic Challenge of Central Bank Credit Policies” and the proposal for a European Credit Council. I review how interdisciplinary scholarship on the political economy of central banking have shown the limits of simple principal-agent framework applied to central bank power and legitimacy. I emphasize why a change to central bank independence is not necessary for a fundamental change in the financial system and credit policies. I also argue that deliberations can have strong effects on decision-making and that the power of the people is not restricted to the legislative power.
Assessment of laboratory capacity in conflict-affected low-resource settings using two World Health Organization laboratory assessment tools
Authors: Markby Jessica , Gygax Monika , Savoy Catherine , Giebens Yves , Janjanin Sanja , Machoka Felicity , Mawina Justin Kinziagu , Ghanem Sahar M.M. , Vetter Beatrice Natalie
Published: January 2023

Objectives

Laboratory diagnostic services are essential to drive evidence-based treatment decisions, manage outbreaks, and provide population-level data. Many low- and middle-income countries (LMICs) lack sufficient diagnostic capacity, often further exacerbated in conflict-affected areas. This project assessed laboratory services in conflict-affected LMICs to understand gaps and opportunities for improving laboratory capacity.

Methods

The World Health Organization Laboratory Assessment Tool Facility Questionnaire (WHO Laboratory Tool) and Stepwise Laboratory Improvement Process Towards Accreditation (SLIPTA) checklist were used to assess five laboratories in Eastern Democratic Republic of the Congo (DRC) and five in Gaza, Palestine. Total scores and percentage outcomes by indicator were calculated.

Results

Average WHO Laboratory Tool score across all facilities was 41% (range 32–50%) in DRC and 78% (range 72–84%) in Gaza. Lowest scoring indicators in DRC were Biorisk management (13%, range 8–21%), Documentation (14%, range 6–21%), and in Gaza, were Facilities (59%, range 46–75%) and Documentation (60%, range 44–76%). Highest scoring indicators in DRC were Facilities (70%, range 45–83%) and Data and Information Management (61%, range 38–80%), and in Gaza were Data Information and Management (96%) and Public Health Function (91%, range 88–94%). In DRC, no laboratory achieved a SLIPTA star rating. In Gaza, two laboratories had a 3-star SLIPTA rating, one had a 2-star rating and two had a 1-star rating.

Conclusions

Laboratory systems in conflict-affected LMICs have significant gaps. Implementating improvement strategies in such settings may be especially challenging.
A Novel Study Based on Shifted Jacobi Polynomials to Find the Numerical Solutions of Nonlinear Stochastic Differential Equations Driven by Fractional Brownian Motion
Authors: Singh P. K. , Saha Ray S.
Published: January 2023

The main objective of this article is to represent an efficient numerical approach based on shifted Jacobi polynomials to solve nonlinear stochastic differential equations driven by fractional Brownian motion. In this method, function approximation and operational matrices based on shifted Jacobi polynomials have been studied, which are further used with appropriate collocation points to reduce nonlinear stochastic differential equations driven by fractional Brownian motion into a system of algebraic equations. Newton’s method has been used to solve this nonlinear system of equations, and the desired approximate solution is achieved. Moreover, the error and convergence analysis of the presented method are also established in detail. Additionally, the applicability of the proposed method is demonstrated by solving some numerical examples.
q-opers,QQ-systems, and Bethe Ansatz II: Generalized minors
Authors: Koroteev Peter , Zeitlin Anton M.
Published: January 2023

In this paper, we describe a certain kind ofq-connections on a projective line, namelyZ-twisted(G,q){(G,q)}-opers with regular singularities using the language of generalized minors. In part one we explored the correspondence between theseq-connections and𝑄𝑄\mathit{QQ}-systems/Bethe Ansatz equations. Here we associate to aZ-twisted(G,q){(G,q)}-oper a class of meromorphic sections of aG-bundle, satisfying certain difference equations, which we refer to as(G,q){(G,q)}-Wronskians. Among other things, we show that the𝑄𝑄\mathit{QQ}-systems and their extensions emerge as the relations between generalized minors, thereby putting the Bethe Ansatz equations in the framework of cluster mutations known in the theory of double Bruhat cells.
A study of the impact of policy interventions on daily COVID scenario in India using interrupted time series analysis
Authors: Chattopadhyay Subhankar , Ghosh Debika , Maiti Raju , Das Samarjit , Biswas Atanu , Chakraborty Bibhas
Published: January 2023

Objectives

The rapid increase both in daily cases and daily deaths made the second wave of COVID-19 pandemic in India more lethal than the first wave. Record number of infections and casualties were reported all over India during this period. Delhi and Maharashtra are the two most affected places in India during the second wave. So in response to this, the Indian government implemented strict intervention policies (“lockdowns”, “social distancing” and “vaccination drive”) in every state during this period to prohibit the spread of this virus. The objective of this article is to conduct an interrupted time series (ITS) analysis to study the impact of the interventions on the daily cases and deaths.

Methods

We collect daily data for Delhi and Maharashtra before and after the intervention points with a 14-day (incubation period of COVID-19) observation window. A segmented linear regression analysis is done to study the post-intervention slopes as well as whether there were any immediate changes after the interventions or not. We also add the counterfactuals and delayed time effects in the analysis to investigate the significance of our ITS design.

Results

Here, we observe the post-intervention trends to be statistically significant and negative for both the daily cases and the daily deaths. We also find that there is no immediate change in trend after the start of intervention, and hence we study some delayed time effects which display how changes in the trends happened over time. And from the Counterfactuals in our study, we can have an idea what would have happened to the COVID scenario had the interventions not been implemented.

Conclusions

We statistically try to figure out different circumstances of COVID scenario for both Delhi and Maharashtra by exploring all possible ingredients of ITS design in our analysis in order to present a feasible design to show the importance of implementation of proper intervention policies for tackling this type of pandemic which can have various highly contagious variants.
Anisotropic nonlinear weighted elliptic equations with variable exponents
Authors: Naceri Mokhtar
Published: January 2023

In this paper we prove the existence of distributional solutions to certain
anisotropic nonlinear weighted elliptic equations with variable exponents, where the weight function belongs to the
anisotropic Sobolev space with variable exponents and zero boundary. The functional setting involves
anisotropic variable exponents Lebesgue–Sobolev spaces.
Super-resolution microscopy and studies of peroxisomes
Authors: Galiani Silvia , Eggeling Christian , Reglinski Katharina
Published: January 2023

Fluorescence microscopy is an important tool for studying cellular structures such as organelles. Unfortunately, many details in the corresponding images are hidden due to the resolution limit of conventional lens-based far-field microscopy. An example is the study of peroxisomes, where important processes such as molecular organization during protein important can simply not be studied with conventional far-field microscopy methods. A remedy is super-resolution fluorescence microscopy, which is nowadays a well-established technique for the investigation of inner-cellular structures but has so far to a lesser extent been applied to the study of peroxisomes. To help advancing the latter, we here give an overview over the different super-resolution microscopy approaches and their potentials and challenges in cell-biological research, including labelling issues and a focus on studies on peroxisomes. Here, we also highlight experiments beyond simple imaging such as observations of diffusion dynamics of peroxisomal proteins.