bluuebunny/crossref_metadata_2025 huggingface dataset:
GIS-Based Analysis of Landslides Susceptibility Mapping: The Case Study of Lushoto District, North Eastern Tanzania.
Authors: Makonyo Michael , Zahor Zahor
Published: January 2023

Landslides are becoming increasingly widespread, claiming tens of thousands of fatalities, hundreds of thousands of injuries, and billions of dollars in economic losses each year. Thus, studies for geographically locating landslides vulnerable areas have been increasingly relevant in recent decades. This research is aimed at integrating Geographical Information Systems (GIS) and Remote Sensing (RS) techniques to delineate Landslide Susceptibility Mapping (LSM) of Lushoto District, Tanzania. RS assisted in providing remotely datasets including; Digital Elevation Models (DEM), Landsat 8 OLI imageries, and spatially distributed landslides coordinates with the use of a handheld Global Position System (GPS) receiver while various GIS analysis techniques were used in the preparation and analysis of landslides influencing factors hence, generating LSM index values. However, rainfall, slope’s angle, elevation, soil type, lithology, proximity to roads, rivers, faults, and Normalized Difference Vegetation Index (NDVI) factors were found to have direct influence on the occurrence of landslides. These factors were evaluated, weighted, and ranked using Analytical Hierarchy Process (AHP) technique in which 0.086 (8.6%) consistency ratio (CR) was attained (highly accepted). Findings reveal that, rainfall (29.97%), slopes’ angle (21.72%), elevation (15.68%), and soil types (11.77%) were found to have high influence on the occurrence of landslides while proximity to faults (8.35%), lithology (4.94%), proximity to roads (3.41%), rivers (2.48%) and NDVI (1.69%) had very low influences respectively. The overall results, obtained through Weighted Linear Combination (WLC) analysis indicate that, about 97669.65 hectares (ha) of the land is under very low landslides susceptibility levels which accounts for 24.03% of the total study area. Low susceptibility levels had 123105.84 ha (30.28%) moderate landslides susceptibility areas were found to have 140264.79 ha (34.50%) while high and very high susceptibility areas were found to cover about 45423.43 ha (11.17%) and 57.78 ha (0.01%) respectively. Furthermore, 81% overall model accuracy was obtained as computed from Area under the Curve (AUC) using Receiver Operating Characteristic (ROC) Curve.
Silver recovery from chemical extract originating from End-of-Life photovoltaic panels using a Microbial Fuel Cell
Authors: Kanellos Gerasimos , Tremouli Asimina , Tsakiridis Petros , Remoundaki Emmanouella , Lyberatos Gerasimos
Published: January 2023

The solar energy sector has grown rapidly in the past decades, addressing the issues of energy security and climate change. Many photovoltaic panels that were installed during this technological revolution, have accumulated as waste and even more are nearing their End-of-Life (EoL). Based on circular economy, a new hydrometallurgical process has been proposed for the management of the EoL PVs. This results in a chemical extract containing 0.7 % w/w Ag, along with various other metals. This study investigates the cell power generation and the kinetics of the silver recovery, along with the parasitic removal of other heavy metals, both from synthetic and the real chemical extract in the cathode of a Microbial Fuel Cell (MFC). The results indicated that silver was completely recovered from the synthetic and the real chemical extract, with a rate of ~82 μmol/h and ~32 μmol/h, respectively. The difference is attributed to the simultaneous reduction of other heavy metals in amorphous compounds, hindering the silver reduction kinetics and leading to a gradual electrode passivation. Nevertheless, silver can be 100% retrieved from the chemical extract, with a purity of 68-96% w/w (average 86% w/w at the end of the batch cycle), in crystal (face center cube) structure, containing minor metal impurities.
Establishment and Application of Cricothyrotomy In Vivo
Authors: SONG Fengxiang , HAN Cailing , QIU Yuxue , HOU Haitao , YAN Xiaoqiong , DENG Liqin
Published: January 2023

Background:
Cricothyrotomy is a procedure performed to establish an airway in critical airway events. It is performed only rarely and anesthesiologists are often unprepared when called upon to perform it. This study aimed to simulate cricothyrotomy using pig larynx and trachea models to help anesthesiologists master cricothyrotomy and improve the ability to establish cricothyrotomy quickly.
Methods:
The porcine larynx and trachea were dissected and covered with pigskin to simulate the structure of the anterior neck of a human patient. An animal model of cricothyrotomy was established. Forty anesthesiologists were randomly divided into four groups. Each physician performed three rounds of cricothyrotomy, and recorded the time to accomplish each successful operation. The satisfaction and application value of all physicians with this animal model were evaluated using percentage scores.
Results:
Through repeated practice, compared with the time spent in the first round of the operation (60 ± 17 seconds), the time spent in the second round of the operation (44 ± 14 seconds) and the time spent in the third round of the operation (36 ± 11 seconds) were significantly shortened (P < 0.05). Finally, 95% of all physicians were very satisfied with this animal model, and 5% were relatively satisfied. In addition, 95% of all physicians rated the application value of this animal model as excellent, and 5% rated it as good.
Conclusion:
The porcine larynx and trachea model is an excellent animal model for simulating and practicing cricothyrotomy, helping anesthesiologists to master cricothyrotomy and to perform it proficiently when required.
Risk Factors Associated with Poor Adherence to Blood Pressure Monitoring in Postpartum Discharged Patients with Hypertensive Disorders of Pregnancy
Authors: Li Jingjing. , Zhou Qin , Wang Yixuan. , Duan Lufen , Xu Guangjuan , Zhu Liping. , Zhou Liping. , Peng Lan. , Tang Lian. , Yu Yanxia.
Published: January 2023

Background
This study aims to investigate the risk factors for poor adherence to BP monitoring within 3 months after discharge from the hospital in postpartum discharged HDP patients. Likewise, females with hypertensive disorders of pregnancy (HDP) in China should have a blood pressure (BP) evaluation continuously for at least 42 days postpartum and have BP, urine routine, and lipid and glucose screening for 3 months postpartum.
Methods
This study is a prospective cohort study of postpartum discharged HDP patients. After telephone follow-up was conducted at 1 week, 6 weeks, and 12 weeks after discharge, the maternal demographic characteristics, labor and delivery details, laboratory test results of patients at admission, and adherence to BP monitoring after discharge were collected. While logistic regression analysis was used to analyze the factors related to poor adherence to BP monitoring, the receiver operating characteristic (ROC) curve was drawn to evaluate the model’s predictive value for the poor adherence to BP monitoring.
Results
In this study, 272 females met the inclusion criteria, and poor adherence to BP monitoring was presented in 182 patients (66.9%). A multivariate logistic regression analysis identified the education level of high school or below (OR 2.787, 95% CI 1.452–5.351), parity (OR 1.622, 95% CI 1.007–2.612), and delivery gestational age (OR 1.254, 95% CI 1.053–1.493) as independent risk factors in predicting a poor adherence to BP monitoring. The ROC curve analysis indicated that the continuous variable delivery gestational age had a significant predictive value for the poor adherence to BP monitoring, which resulted in a cutoff point of 33.4 weeks. Parity had a limited predictive value, with a cutoff point of 2. The established prediction regression model combined education level, parity and delivery gestational age had the maximal area under the curve (AUC, AUC = 0.746) and better sensitivity (66.5%) and specificity (71.1%).
Conclusion
Poor adherence to BP monitoring is a common state in postpartum HDP patients after discharge. Females with an education level of high school or below, a parity of two or more, and delivered at gestational age ≥ 33.4 weeks were unlikely to adhere to BP monitoring after discharge.
Non-Accidental Trauma Screening in a Pediatric ED; Does TRAIN(ing) Help?
Authors: Heyming Theodore , Knudsen-Robbins Chloe , Sharma Supriya , Thackeray Jonathan , Schomberg John , Lara Bryan , Wickens Maxwell , Wong Daphne
Published: January 2023

Background
Child maltreatment is distressingly prevalent yet remains under-recognized by healthcare providers. In 2015 the Ohio Children's Hospital Association developed the Timely Recognition of Abusive INjuries (TRAIN) collaborative in an effort to promote non-accidental trauma (NAT) screening. Our institution implemented the TRAIN initiative in 2019. The objective of this study was to examine the effects of the TRAIN initiative at this institution.
Methods
In this retrospective chart review we recorded the incidence of sentinel injuries (SIS) in children presenting to the Emergency Department (ED) of an independent level 2 pediatric trauma center. SIS were defined and identified by a diagnosis of ecchymosis, contusion, fracture, head injury, intracranial hemorrhage, abdominal trauma, open wound, laceration, abrasion, oropharyngeal injury, genital injury, intoxication, or burn in a child < 6.01 months of age. Patients were stratified into pre-TRAIN (PRE), 1/2017-9/2018, or post-TRAIN (POST), 10/2019-7/2020, periods. Repeat injury was defined as a subsequent visit for any of the previously mentioned diagnoses within 12 months of the initial visit. Demographics/visit characteristics were analyzed using Chi square analysis, Fischer’s exact test, and student’s paired t-test.
Results
In the PRE period, 12,812 ED visits were made by children < 6.01 months old; 2.8% of these visits were made by patients with SIS. In the POST period there were 5,372 ED visits, 2.6% involved SIS (p = .4). The rate of skeletal surveys performed on patients with SIS increased from 17.1% in the PRE period to 27.2% in the POST period (p = .01). The positivity rate of skeletal surveys in the PRE versus POST period was 18.9% and 26.3% respectively (p = .45). Repeat injury rates did not differ significantly in patients with SIS pre- versus post-TRAIN (p = .44).
Conclusion
Implementation of TRAIN at this institution appears to be associated with increased skeletal survey rates, suggestive of improved NAT evaluation.
Paclobutrazol suppresses the synthesis of key secondary metabolites by antagonizing gibberellin signaling in Pseudostellaria heterophylla
Authors: Xiao Chenghong , Zhang Jinqiang , Zhang Chen , Ouyang Zhen , Wu Taosheng , Yang Changgui , Yuan Qingsong , Xu Jiao , Li Liangyuan , Zhou Tao
Published: January 2023

Background：Pseudostellaria heterophyllais one of the most well-known traditional Chinese medicines, and its secondary metabolites play an important medicinal role. Paclobutrazol (PBZ), an antagonist of the plant hormone gibberellin, is widely used to increase the yield of P. heterophylla. Whether PBZ affects the synthesis and accumulation of the plant’s secondary metabolites is unclear. Here we investigated the effects of PBZ on the production of polysaccharides, saponins and heterophyllin B in the root tubers of P. heterophylla, and further explored its molecular mechanisms.
Results：We found that PBZ promoted the yield of P. heterophylla, but reduced the accumulation of polysaccharides, saponins and heterophyllin B. PBZ dramatically downregulated genes associated with gibberellin synthesis and reduced concentration of the hormone in root tubers. Inhibition of gibberellin signaling by PBZ altered the expression of genes involved in synthesis and metabolism of polysaccharides, saponins and heterophyllin B.Exogenous gibberellin reversed these effects.
Conclusion：These results suggest that PBZ suppresses the synthesis of saponins, polysaccharides and heterophyllin B by antagonizing gibberellin signaling in P. heterophylla, providing important guidance for its cultivation.
Restoration of Intrinsic Hand Function By Superficial Radial Nerve: An Anatomical Study
Authors: Liang Shuo , Liu Yu-Zhou , Hu Xiao-Qian , Zhao Xin , Lao Jie
Published: January 2023

Background:Contralateral seventh cervical(cC7) nerve root transfer is one of the most important techniques for treating total brachial plexus avulsion injury. The traditional cC7 uses the whole ulnar nerve as a graft, which sacrifices the restorative potential of the ulnar nerve.
Objective: This innovative cadaveric study aims to evaluate the possibility and feasibility of modified cC7 that preserve the motor branch of the ulnar nerve(MBUN), after cC7, using recovered superficial radial nerve(SRN) to repair.
Methods: Ten adult cadavers provided by the Anatomy, Histology, and Embryology Department of Fudan University, China were dissected to evaluate the feasibility of this technique. In this study, only the dorsal and superficial branches of the ulnar nerve and SRN were harvested to connect the cC7 nerve and the recipient nerves. Both the median nerve and MBUN were the recipient nerves. To evaluate the feasibility, the SRN, as well as the motor and sensory branches of the ulnar nerve were dissected. The distances from the reverse point of SRN to wrist flexion crease, as well as to the coaptation point of SRN and MBUN were measured. The MBUN was dissected from distal to proximal and the maximum length was measured. The diameter of nerve branches and the number of axons were evaluated.
Results:This modified approach was technically feasible in all limbs. The distances from the reverse point of SRN to wrist flexion crease was 8.20±1.72cm, and that to the coaptation point was 6.63±1.67cm. The maximum length of the MBUN was 7.44±1.16cm. The mean diameters of axons of the MBUN and SRN distal lateral and medial branches were 1.85±0.41mm、1.99±0.45mm and 1.57±0.37mm, respectively. The corresponding mean numbers of axons were 1401±140 and 742 ±73、712 ±59, respectively.
Conclusion: The SRN could be transferred to the MBUN without a nerve graft. The possible advantage of this modification was that the potential of MBUN was preserved.
Understanding Integrated Hpv Testing and Treatment of Pre- Cancerous Cervical Cancer in Burkina Faso, Cote D’Ivoire, Guatemala and Philippines: Study Protocol
Authors: Kabue Mark , Gauvreau Cindy L. , Daceney Nemdia , Bertram Margaret Mary , Shissler Tracey , Reis Veronica , Dodo Mathurin , Garces Ana , Llave Cecilia , Dao Blami , Huang Lisa
Published: January 2023

Background
Many low- and-middle-income countries are disproportionately burdened by cervical cancer, resulting in high morbidity and mortality. HPV-DNA testing couple with treatment with thermal ablation is a recommended screening and precancer treatment strategy, but not enough is known about how this can be effectively implemented in the context of integrated services. The (Scale Up Cervical Cancer Elimination by Secondary prevention Strategy, (SUCCESS) project is conducting a study to understand this approach, integrated into existing women’s health services in Burkina Faso, Cote d’Ivoire, Guatemala, and the Philippines.
Methods
A hybrid effectiveness-implementation type III mixed-methods observational study design is used to assess feasibility, acceptability, and costs of integrated service delivery in 10 sites per country, selected considering urban/rural location, facility level, onsite/offsite laboratories, and health services type. A combined sample size of about 8,000 women aged 25–49 years was computed, 15% being HIV positive, thus about 2000 per country. The primary outcome is proportion of HPV positive women completing precancer treatment, if eligible, within three months of screening. Data collection and analysis includes; facility and client exit surveys, key informant and client interviews, registries and project records extractions, and costing data analysis. Analysis includes descriptive statistics, context description, thematic analysis, and document analysis. Quantitative analyses will be stratified by participant’s HIV status.
Discussion
Recruitment is ongoing; started in April 2022 (Burkina Faso and Côte d’Ivoire) and August 2022 (Guatemala and the Philippines). Follow-up of study participants 12-months post-treatment is expected to be completed for all countries by April 2024. In LMICs, integrating cervical cancer secondary prevention services into other health services will likely require specific rather than incidental recruitment of women for screening. Reconfiguration of laboratory infrastructure and planning for sample management must be made well in advance to meet induced demand for screening.
Registration:
ClinicalTrials.Gov ID: NCT05133661 (24/11/2021)
Improvement of oral health knowledge and behavior of diabetic patients: An interventional study by using the social media
Authors: Haghdoost Atousa , Bakhshandeh Soheila , Tohidi Sajjad , Ghorbani Zahra , Namdari Mahshid
Published: January 2023

Background: Diabetic patients are not often aware of the relationship between diabetes mellitus (DM) and periodontal diseases, and researchers recommend further knowledge enhancement of diabetic patients in this regard. This study aimed to enhance the oral health knowledge of diabetic adults through an educational intervention.
Methods: In this interventional study, three private offices of endocrinologists specialized in treatment of DM were selected for recruitment of the participants. Totally, 120 diabetic adults (40 from each office) participated in an educational intervention in three groups (patients from each office comprised one group): (I) physician-aid (receiving an educational brochure and CD from their endocrinologist), (II) researcher-aid (receiving an educational brochure and CD from the researcher), and (III) social media (joining an educational group in WhatsApp for 3 months). A self-reported standard questionnaire was filled out by patients before and after the intervention to assess oral health knowledge. Data were analyzed by SPSS version 21 using independent t-test, Mann-Whitney test, Chi-square test, and ANCOVA.
Results: The mean oral health knowledge score increased in all three groups after the educational interventions (P<0.001); the highest increase occurred in the social media group. Toothbrushing twice daily or more had the greatest improvement in physician-aid group compared with the other two groups (P<0.001). The greatest improvement in dental flossing once daily or more occurred in the social media group (P=0.01). The mean level of the hemoglobin A1c (HbA1c) decreased in all three groups but not significantly (P=0.83).
Conclusion: The results revealed that educational interventions enhance the oral health knowledge and improve the behavior of diabetic adults. Education through the social media can be an efficient method for knowledge enhancement of diabetic patients.
Validation of CYGNSS soil moisture products using in-situ measurments: A case study of Southern China
Authors: Dong Zhounan , Jin Shuanggen , Li Li , Wang Peng
Published: January 2023

In terrestrial remote sensing applications, the spaceborne Global Navigation Satellite System-Reflectometry (GNSS-R) has demonstrated its worth. The application to land surface soil moisture (SSM) detection is particularly intriguing since it has the ability to provide fine-scale results to supplement traditional satellite-based active and passive missions. To date, many retrieval algorithms for spaceborne GNSS-R have been developed in order to produce SSM products. However, detailed product reliability and robustness evaluations are still absent. In this study, the satellite-based microwave radiometry product, the model-base product, and in-situ measurements from the Chinese soil moisture monitoring network with over 1800 ground stations during the year 2018 were used to evaluate the CYclone Global Navigation Satellite System (CYGNSS) mission Level-3 SSM products released by the University Corporation for Atmospheric Research (UCAR) and the University of Colorado at Boulder (CU). Typical relative skill metrics and triple collocation-based metrics, along with corresponding confidence intervals, are given to analyze the performance. According to the pixel-by-pixel validation and overall statistical findings, the results reveal that the current CYGNSS-based SSM exhibits low performance in southern China when compared to the radiometry-based data with a low R2 (median R2=0.09) and the ubRMSD 0.055 cm3cm-3, which is poorer than the results from SMAP against in-situ measurements (median R2=0.25, ubRMSD=0.046 cm3cm-3). To acquire better results to support the related operational applications in the future, the new enhanced retrieval algorithms and high-accuracy calibration referenced data must be used.
Risk Factors and Attitudes towards Osteoporosis among the Palestinian Females in Occupied Palestinian Territories
Authors: Natour Nihal , alshawish Eman , Tell Mariam A
Published: January 2023

Introduction:
Osteoporosis is a leading cause of fracture associated mortality and morbidity and its prevention is important for Palestinian society.
Methods:
A structured questionnaire was distributed to females in Palestinian territories about risk factors for osteoporosis and attitudes towards the diseases. Data was analyzed using SPSS.
Results:
92 women participated in this study, among studied women only 7 were postmenopausal, Age was 30.8±12.3 y, BMI is 25.1± 6.6 Kg/m2, attitude score was 5.75±1.6. 58% had bachelors degree, 44% were teachers, 23.5% were health workers. 65.9% lived in separate houses. Having job was associated with lower attitude towards importance (0.04) of osteoporosis but improved dairy products consumption. The rate of consuming dairy product on regular basis was higher than 50% , but there was high rate of vitamin D deficiency (37%) and low level of physical activity performance (18%).
Conclusion:
There is high prevalence for osteoporosis risk factors, but high rate of using dairy products, and modest attitude towards importance of osteoporosis
Implantation of Ascyrus Medical Dissection Stent, Our First-Hand Experience
Authors: Kanj Mohammad , Cosset Benoit , Oliny Alexandre , Farhat Fadi
Published: January 2023

Background
Acute type A aortic dissection is associated with high perioperative amorbidity and mortality. Ascyrus Medical Dissection Stent is a novel uncovered hybrid stent graft developed to be used as an adjunct to standard surgical approach to promote true lumen expansion and enhance aortic remodeling.
Methods
From March 2021 to March 2022, four consecutive patients presented with acute Debakey type I aortic dissection and underwent emergent surgical repair with David procedure and implantation of AMDS. We reviewed patient’s files retrospectively and described the perioperative outcomes.
Results
All four device implantations were successful. Overall 30-day mortality was 0%. Malperfusion that was present in two patients pre-operatively improved after AMDS implantation. No aortic reinterventions were needed. No aortic injury related to the device was noted. Favourable changes in aortic true lumen and false lumen dimensions were found in most of our patients but the AMDS was compressed at the isthmus in one patient.
Conclusion
AMDS is a reliable and secure device. However, its benefits remain unclear when it comes to a positive remodeling and seems less likelihood comparable to a frozen elephant trunk. The main reason seems to be an insufficient radial force of the AMDS.
Glaciers and postglacial ecosystems: common goods to protect in the Anthropocene
Authors: Bosson Jean-Baptiste , Huss Matthias , Cauvy-Fraunié Sophie , Clément Jean-Christophe , Costes Guillaume , Fischer Mauro , Poulenard Jérôme , Arthaud Florent
Published: January 2023

Glacier shrinking and the development of postglacial ecosystems related to anthropogenic climate change is one of the fastest ongoing ecosystem shifts, with paramount ecological and societal cascading consequences globally (Huss et al., 2017; Milner et al., 2017; Cauvy and Dangles, 2019; IPCC, 2021). Yet, no complete spatial analysis exists to quantify or anticipate this major changeover (Ficetola et al., 2021; Zimmer et al., 2022). Here we model glacier responses to climate projections until 2100 and subglacial terrain to explore the ecological trajectory of all glaciated areas, outside the Antarctica and Greenland ice sheets. Depending on climate change magnitude, glaciers could lose less than one quarter to half of their area by 2100. Mainly composed of terrestrial, then marine and freshwater areas, deglaciated areas could range from the equivalent surface of Nepal to Finland. Ecological conditions in deglaciated areas will remain extreme in some regions, offering refuges for cold-adapted species, but become mild in others, favouring biogeochemical processes, primary productivity and generalist species. This unprecedented travel into the future of cold regions shows that glaciers and postglacial ecosystems have key roles to play to face climate change, biodiversity loss and freshwater scarcity. Less than a third of these vulnerable common goods, barely considered in nature conservation policies (IPBES, 2019), are located within protected areas. We therefore call to urgently enhance both climate change mitigation and the in-situ protection of these key ecosystems to secure their existence, functioning and values.
Evaluating the effectiveness of Chlorhexidine on Gram-positive and Gram-negative bacteria in Iran: a systematic review
Authors: Abniki Reza , Masoudi Melika , Tashakor Amirhosein , Mansury Davood
Published: January 2023

Objective(s): Chlorhexidine is a highly effective, broad-spectrum antimicrobial agent available as a mouthwash, gel, spray, root canal rinse, and periodontal chips. Different results of the effectiveness of this substance have been reported in the studies, hence the aim of this survey is a systematic review of the studies conducted on the minimum inhibitory concentration(MIC) of chlorhexidine on Gram-positive and Gram-negative bacteria isolated in health care centers in Iran.
Materials and Methods: The data of this systemic review study were searched from international database including EMBASE, Scopus, PubMed/Medline and Cochrane library using appropriate English keywords until October 2022 and after filtering based on inclusion and exclusion criteria, 12 articles entered our study.
Results: Out of a total 12 articles, 7 studies were conducted on Gram-positive bacteria,4 studies were conducted on Gram-negative bacteria and 1 study was assessed on both groups. Most studies have been done on Staphylococcus aureus and Pseudomonas aeruginosa. The lowest and admissible MIC was 0.5 µg/mL and on the flip side the highest was 625 µg/mL.
Conclusion: Based on our analysis, antibacterial activity of chlorhexidine against Gram-negative and positive bacteria was discouraging. However, further clinical studies are necessitated to provide clinical evidence to support these observations.
Characteristic Analysis of Fingerprint Datasets from a Pragmatic View of Indoor Localization using Machine Learning Approaches
Authors: Mallik Manjarini , Chowdhury Chandreyee
Published: January 2023

Due to their availability on commercial smartphones, WiFi, Bluetooth, and magnetometer are commonly utilized for indoor localization as indoor spaces are GPS deprived. Indoor localization falls into the category of data-intensive applications. In this domain, most of the recent solution approaches deploy MachineLearning (ML) and Deep Learning (DL) techniques on the data collected through the sensors. However, the publicly available benchmark datasets on indoor localization suffer from certain issues requiring complicated and customized data preprocessing techniques for each dataset for applying a common ML/DL technique. Thus, a fair comparison of the ML/DL methods for indoor localization datasets and hence, checking for the generality of a solution that spans across different indoor regions become infeasible. In this comparative study, we have investigated three key challenges of fingerprint datasets that should be addressed for real-life localization applications, namely, (i) repetitive site survey, (ii) device heterogeneity, (iii) granularity, and subregion-specific performance variation. To demonstrate how these attributes might impact localization performance, experimental analysis is done using five benchmark datasets. The novelty of the work is that it not only highlights the challenges but also analyse the feasibility of possible future directions to address these challenges through implementation results. Formulating the application of a generative adversarial network (GAN) to address the issue of repetitive site surveys has been discussed with implementation results.
Association mapping of rapid visco analyzer traits
Authors: zhu cheng
Published: January 2023

The viscous coefficient and amylose content are the important target for evaluating rice cooking and eating quality. In this study we got the genome-wide association analysis results of amylose content (AC) and parameters value of starch rapid visco analyzer (RVA) PKV, HPV, CPV, BDV, SBV, CSV, GT and PeT through 179 rice core germplasm materials. We detected 170 associated QTL locus all of the nine characters, including a number of the same QTL locus of control multiple traits on chromosome 1, 2, 5, 6, 7, 9 and 12. About 21 QTL locus have been reported related to starch synthesis genes in rice. Starch synthase (include straight-chain starch synthase genes (GBSS) and branched chain starch synthase genes(SS)) had effect on all traits. And three materials of NIP/ZS97 CSSL single segment, one material of ACC9/ZS97 CSSL single segment and one material of NIP/9311 CSSL single segment could confirm nine QTLs which effect on BDV, SBV, PKV and CSV were scanned by association analysis on chromosome 1、3、7 and 8. In the start stage of starch synthesis, participate in the regulation of glucose − 6 - phosphate (Glc6p) →glucose − 1 - (Glc1p) and phosphate Glc1p →UDPGlc way's gene GPT and PGM had a specificity effect on the traits of BDV and SBV, but had little effect on other traits.
The effect of pairing assistance under medical alliance policy on healthcare utilization for patients with chronic diseases in rural China
Authors: Li Mingyue , Zhu He , Tang Haoqing , Cheng Xiaoran , Liu Xiaoyun
Published: January 2023

Pairing assistance (PA) of health professionals between county hospitals and township health centers is one of the key components of the reform of medical alliances in China to strengthen the development of health workforce in primary health care (PHC). This study aims to examine the effect of PA on healthcare utilization for patients with chronic diseases in rural areas. Two waves of National Health Services Survey (2013 and 2018) were used. A total of 13893 and 22725 rural residents with chronic diseases were included in the 2013 and 2018 waves, respectively. Multiple logistic regressions were used to examine the associations between PA and outpatient and inpatient service utilization in PHC. Chow test was used to examine the difference between PA in two models. Among rural patients with chronic diseases, two-week outpatient visits increased from 22.69–27.54%, and annual hospitalization admission increased from 20.72% in 2013 to 25.44%. PA was associated with a significant decrease in outpatient visits (p < 0.001) in 2018 after controlling for individual and county characteristics. Patients in PA counties were 1.45 times (95% CI 1.10–1.90) more likely to use PHC outpatient care in 2013, but the difference disappeared in 2018 (OR = 0.85, 95% CI 0.71–1.01). PA did not reverse the downward trend in the share of PHC outpatient visits. PA under medical alliances in China provides a potential model for building integrated people-centered health systems for other low- and middle-income countries.
Comparison of staged LLIF combined with posterior instrumented fusion and posterior instrumented fusion alone for adult degenerative lumbar scoliosis with sagittal imbalance
Authors: Lai Oujie , Li Hao , Chen Qixing , Hu Yong , Chen Yunling
Published: January 2023

Background
To retrospectively compare the clinical and radiological results of staged lateral lumbar interbody fusion (LLIF) combined with posterior instrumented fusion（PIF）and PIF alone for adult degenerative lumbar scoliosis (ADLS) with sagittal imbalance.
Methods
ADLS patients with sagittal imbalance underwent corrective surgery were divided into staged group (multilevel LLIF at the first stage and PIF at the second stage) and control group (PIF alone). The clinical and radiological outcomes were evaluated and compared between the two groups.
Results
Forty-five patients with average age of 69.7±6.3 years were enrolled, including 25 in staged group and 20 in control group. Compared with preoperative values, both groups achieved significant improvement in terms of ODI, VAS back, VAS leg and spinopelvic parameters after surgery, which were well maintained during the follow-up period. Compared with control group, staged group showed more operative time, however, less blood loss and blood transfusion. The average posterior fixation segments were 6.2±1.78 in staged group and 8.25±1.16 (P<0.01), respectively. Posterior column osteotomy (PCO) was performed in 9 patients (36%) in staged group. PCO and/or pedicle subtraction osteotomy were performed in 15 patients (75%) in control group (P<0.01). No difference was observed between the two groups regarding complication.
Conclusion
Both surgical strategies were effective treatments for ADLS with sagittal imbalance. However, staged treatment was more minimal invasive. The first stage LLIF could simplified second stage posterior procedure, reducing the number of posterior fixation segments and osteotomy requirement.
High expression of TLR2 influenced immune infiltration in pancreatic cancer
Authors: Liu Jinyang , He Miao
Published: January 2023

Purpose
Pancreatic cancer showed specific immunological microenvironment. For a better understanding of relative valuable biomarkers, correlation between prognostic differentially expressed immunity genes and immunological microenvironment in online pancreatic cancer datasets was evaluated.
Methods
ssGSEA algorithm was used to evaluate the immunological characteristics in tumor samples. Limma algorithm was used to assess the differentially expressed genes, survival analysis was performed by Cox models and Kaplan Meiers method, gene sets enrichment analyses were conducted to evaluate the correlation between prognostic differentially expressed genes expression and GO/KEGG terms. ESTIMATE and CIBERSORT algorithms were used to evaluate the immune infiltration in tumor immunological microenvironment. Receiver operating characteristic analysis was performed to evaluate the diagnostic and prognostic value of prognostic differentially expressed genes in pancreatic cancer patients.
Results
High immune infiltration was demonstrated to be related with poor prognosis in pancreatic cancer. Four genes including TLR2 were identified as prognostic differentially expressed immunity genes in pancreatic cancer, high TLR2 expression was correlated with high infiltration and poor prognosis, furthermore, TLR2 expression was correlated with opposite survival in early/advanced stages. High TLR2 expression was correlated with immune-related pathways, functions and processes and indicated high immune infiltration of immune cells including activated memory CD4+ T cells, M2 macrophages and rested dendritic cells and low immune infiltration of regulatory T cells, activated natural killer cells and plasma cells. Moreover, TLR2 showed a moderate predictive accuracy in the diagnosis of pancreatic cancer.
Conclusion
Correlation between TLR2 and immune infiltration in pancreatic cancer was identified.
The theory of sandy land soil hydrology and mode of low coverage afforestation in northwest China
Authors: Wang Mingyuan
Published: January 2023

Most of the sandy land areas in northwest China belong to semi-arid area and the average annual rainfall is about 250-500 mm. Sandy land has the potential to reverse itself when man-made pressure is removed. The specific permeability structure of sandy soil showed heterogeneous anisotropy in the horizontal direction (x or y) of the soil surface (0-10cm), and showed interlayer homogeneity and isotropy in the vertical direction (z) of the underlying of soil surface, which formed rainfall infiltration process of the special combination of both channel flow and capillary flow percolation systems in sandy soil. It is reflected in the combination structure of "source" and "reservoir" in the soil water profile due to lateral gravity water recharge. There is no hydraulic relation between large area exposed sandy land and groundwater, and the modelof shrub community consuming soil water reflects the relationship between soil water deficit and free gravity water recharge in sandy land formed by precipitation. On the one hand, sandy land afforestation preserves a part of bare sandy land intermittently to gather surface and subsurface soil runoff (or called collecting internal drainage from source), and adopting sandy land afforestation methods and techniques with low coverage and patch vegetation configuration. On the other hand, shrub plants in sandy land have a higher root-shoot ratio. According to the balance between soil water storage (collection) and vegetation water consumption, plantation vegetation coverage in sandy land can be determined by the square of root-shoot ratio . This formula indicates that the deep roots and horizontal ductility of plants in sandy land expand the soil water space available to vegetation under drought conditions so that the water consumption of transpiration is relatively supplemented. These two aspects are the key to the success of large-scale desertification control and afforestation.
A cross-sectional study on depression and its associated factors among adults in urban Can Tho, Vietnam
Authors: Phuc Lam Duong , Ho Nhan The
Published: January 2023

Background
This study set out to determine the prevalence of depression and its associated factors in Can Tho City, Vietnam's urban community.
Methods
A cross-sectional descriptive study with a sample of 449 people aged 18 to 60 years old was conducted in Ninh Kieu district, Can Tho city, from September 2015 to June 2016. Depression was measured using the PQH-9 Patient Health Scale. The total PHQ-9 scores ranged from 0 to 27. Scores of 5, 10, 15, and 20 represent cut-off scores for mild, moderate, and major depression, respectively. and analyze related factors by multivariable logistic regression.
Results
Sixteen percent of participants met the cutoff point for depression, a score of 5 or over. There were 12.2% with mild depression, 2.9% with moderate depression, 0.7% with moderately severe depression, and 0.2% with severe depression. Chronic diseases (OR = 2.79; p = 0.005), introversion/affectivity (OR = 3.12; p = 0.002), failure in work or study (OR = 4.40; p <0.001), family history of mental illness (OR = 8.93; p = 0.029), family unhappiness (OR = 5.61; p = 0.002), and relatives dying or suffering from severe illness (OR = 2.75; p = 0.004).
Conclusion
This study provides an alarming signal for health professionals and health policymakers in Can Tho City about the need for better recognition of depression and its associated factors in adult people.
A Brief Questionnaire for Measuring Alarm Fatigue in Nurses and Physicians in Intensive Care Units
Authors: Wunderlich Maximilian Markus , Amende-Wolf Sandro , Krampe Henning , Kruppa Jochen , Spies Claudia , Weiß Björn , Memmert Belinda , Balzer Felix , Poncette Akira-Sebastian
Published: January 2023

Background. When exposed to hundreds of medical device alarms per day, intensive care unit (ICU) staff can develop “alarm fatigue” (i.e., desensitisation to alarms). However, no standardised way of quantifying alarm fatigue exists.
Objective. We aimed to develop a brief questionnaire for measuring alarm fatigue in nurses and physicians.
Methods. After developing a list of initial items based on a literature review, we conducted 15 cognitive interviews with the target group (13 nurses and two physicians) to ensure that the items are face valid and comprehensible. We then asked 32 experts on alarm fatigue to judge whether the items are suited for measuring alarm fatigue. The resulting 27 items were sent to nurses and physicians from 15 ICUs of a large German hospital. We used exploratory factor analysis to further reduce the number of items and to identify scales.
Results. A total of 585 submissions from 707 participants could be analysed (of which 14% were physicians and 64% were nurses). The simple structure of a two-factor model was achieved within three rounds. The final questionnaire (called Charité Alarm Fatigue Questionnaire; CAFQa) consists of nine items along two scales (i.e., the “alarm stress scale” and the “alarm coping scale”).
Conclusion. CAFQa is a brief questionnaire that allows clinical alarm researchers to quantify the alarm fatigue of nurses and physicians. It should not take more than five minutes to administer.
New insights of the pharmacological properties of curcumin: cytotoxicity and immuno-modulation study
Authors: Derguine Rania , Rezgui Abdelmalek , Tachour Rechda Amel , Khenchouche Abdehalim , Cherif Djaouida , Rym Agred , Meziti Hicham , Hareiche Mohammed ,   Amina Lamouri1, Bouriche hamama , Benguerba Yacine , Sobhi Widad
Published: January 2023

The current study aims to appreciate curcumin’s anti-inflammatory and immuno-modulation properties through the investigation of its effect on the neutrophil enzymes (MPO and elastase) activities. The toxicity of pure curcumin was studied using three cell types: human neutrophils, NOD mouse Langerhans β cell line (NIT-1), and mouse breast cancer carcinoma cell line (EMT-6). Neutrophil isolation from whole blood was assessed using the histopaque gradient density method. After the MPO and elastase extraction from isolated neutrophils, the modulatory effect of curcumin on the activity of these enzymes was assayed using 3,3′,5,5′- tétramethylbenzidine and le N-Methoxy-Suc-(Ala)2-Pro-Val-p-Nitroanilide as specific substrates, respectively. Also, the Cytotoxic of curcumin was investigated on the EMT6, NIT-1, and neutrophils cells using XTT and trypan blue exclusion assays, respectively. Results indicate that curcumin modulates the neutrophil's activity by inhibiting its enzymes. In effect, curcumin exerts a significant dose-dependent inhibitory effect on both MPO and elastase activities with IC50 of 14.41± 1.74 μg/ml and 6.06± 3.67 μg/ml. On the other hand, we reveal that curcumin significantly decreases neutrophil viability in a dose-dependent manner with IC50 = 25.60 ± 7.88 μg/ml. Moreover, no significant cytotoxic effect on EMT6 and NIT-1cells lines was shown. The IC50 of EMT6 breast cancer cell and NIT-1cell lines were higher than 30 μg/ml and 60 μg/ml, respectively. While, doxorubicin, an anti-cancer drug used as a positive control, significantly reduces EMT6 viability with IC50 of 4.885± 0.063 μg/ml. These results indicate that curcumin has a potential anti-inflammatory effect considering neutrophil viability and some of its activities. Moreover, curcumin has shown selective cytotoxicity toward neutrophils with no prominent cytotoxic effect on EMT6 and NIT-1 cell lines. Given these results, we can think of proposing curcumin for anti-inflammatory and immunomodulatory use.
Continuation Newton methods with deflation techniques for global optimization problems
Authors: Luo Xin-long , Xiao Hang , Zhang Sen
Published: January 2023

The global minimum point of an optimization problem is of interest in engineering fields and it is difficult to be solved, especially for a nonconvex large-scale optimization problem. In this article, we consider a new memetic algorithm for this problem. That is to say, we use the continuation Newton method with the deflation technique to find multiple stationary points of the objective function and use those found stationary points as the initial seeds of the evolutionary algorithm, other than the random initial seeds of the known evolutionary algorithms. Meanwhile, in order to retain the usability of the derivative-free method and the fast convergence of the gradient-based method, we use the automatic differentiation technique to compute the gradient and replace the Hessian matrix with its finite difference approximation. Accordingto our numerical experiments, this new algorithm works well for unconstrained optimization problems and finds their global minima efficiently, in comparison to the other representative global optimization methods such as the multi-start methods (the built-in subroutine GlobalSearch.m of MATLAB R2021b, GLODS and VRBBO), the branch-and-bound method (Couenne, a state-of-the-art open-source solver for mixed integer nonlinear programming problems), and the derivative-free algorithms (CMA-ES and MCS).
Mathematics Subject Classification (2010) 65K05 · 65L05 · 65L20
Hospital mortality of blunt abdominal aortic injury (BAAI): a systematic review and meta-analysis
Authors: Li Mingxuan , Yan Yu , Wang Chaonan , Tu Haixia
Published: January 2023

Background
Studies on the mortality of blunt abdominal aortic injury (BAAI) are rare, and the rates reported by them vary widely. We aimed to quantitatively analyze the data retrieved and reveal the hospital mortality of this disease more precisely.
Methods
Published studies were searched on Excerpta Medica Database (Embase), PubMed, Web of Science (WOS) and Cochrane Library without date restriction. We set the overall hospital mortality (OHM) and its 95% confidence interval (CI) of BAAI patients as the primary outcome measure. English references with data that met the selection criteria were included. The quality of all included studies was assessed by the Joanna Briggs Institute (JBI) checklist and the American Agency for Health Care Quality and Research’s (AHQR) cross-sectional study quality evaluation items. After data extraction, a meta-analysis was performed using the metaprop command of joint the Freeman-Tukey double arcsine transformation of data in Stata 16 software. Heterogeneity was assessed and reported as a percentage using the I² index value and as a P value using the Cochrane Q test. And various methods were used to find out the source of heterogeneity and analyze the sensitivity of the computation model.
Results
Of 2,147 references screened, 5 studies that involve 1,593 patients were included because of meeting the selection criteria. There were no low-quality references after assessment. There was 1 study that only included 16 juvenile BAAI patients was excluded from the meta-analysis of the primary outcome measure due to great heterogeneity. Because of low heterogeneity (I2 = 47.6%, P = 0.126 for Q test) after analysis using a random effects model, pooling the ESs of remaining four references using a fixed effects model yielded an OHM = 28.8% (95% CI, 26.5%-31.1%). The good stability of the model was verified by checking calculation. Egger’s test yielded P = 0.339, which shows the low publication bias of the model. In addition, we also performed meta-analyses and obtained the pooled hospital mortality of operation [13.5% (95%CI, 8.0%-20.0%)] and the pooled hospital mortality of non-operation [28.4% (95%CI, 25.9%-31.0%)] of BAAI, respectively.
Conclusions
BAAI has an OHM of 28.8%. This serious disease deserves more attention and research.