bluuebunny/crossref_metadata_2025 huggingface dataset:
Investment Propensity and Efficiency of ESG Excellent Companies
Authors:   Korea Accounting Information Association, Kim Hyuntae , Kim Donghyun
Published: October 2023

[Purpose]This study empirically examines the relationship between investment propensity and investment efficiency in the case of excellent ESG performance for companies listed on the Korea Exchange.
[Methodology]Assuming that the stocks (companies) included in the ‘ESG Leaders 150 Index’ operated by the Korea Exchange are companies with excellent ESG performance, an empirical analysis was conducted on domestic listed companies from 2018 to 2022.
[Findings]As a result of empirical analysis, under－investment propensity generally appeared when it was judged to show excellent performance and it was also found to be low in terms of investment efficiency. These results were maintained in the analysis conducted on relatively KOSPI listed companies, and it was found that there was no effect on KOSDAQ listed companies. The analysis result of this study is judged to be a phenomenon that occurs because the benefits of ESG performance do not exceed related costs or are not shown in financial statements. Therefore, as continuously suggested in previous studies, it suggests the need for a standard that can adequately represent ESG performance.
[Implications]This study differs from previous studies in that it expands related literature by identifying companies with excellent ESG performance by utilizing the Korea Exchange’s ESG－related theme index. In addition, given that ESG investment enhances expectations for new investment directions, comparative analysis of investment efficiency provides an implication that investors should pay attention.
INFLUENCE OF PROFITABILITY, SOLVENCY, COMPANY SIZE, AND AUDITOR'S OPINION ON AUDIT DELAY
Authors: Murdiansyah Isnan , Wulan Sari Febianty
Published: October 2023

There are many cases of companies that are late in reporting financial statements because an audit by an independent auditor takes quite a long time before being submitted to the OJK for publication. This study aims to determine the effect of profitability, solvency, company size, and auditor's opinion on audit delay in healthcare companies listed on the IDX from 2019 to 2021. This study uses purposive sampling; the population is healthcare companies listed on the Indonesia Stock Exchange, and the sample size is 54. This research applies data analysis, namely multiple linear regression analysis with a panel data regression model. Since this research uses the combined data of time series and cross-section, the analytical technique used in the analysis process to obtain more accurate results is multiple linear regressions with panel data. The data obtained is then processed using Microsoft Excel and SPSS version 26. The results show that the variables of profitability, solvency, firm size, and auditor's opinion have no significant effect on audit delay; those variables also have no simultaneous effect on audit delay.
Keywords: Profitability, Solvency, Company Size, Auditor Opinion,  Audit Delay.
SMALL AND MEDIUM ENTERPRISE DEVELOPMENT STRATEGY: SWOT-BALANCED SCORECARD PERSPECTIVE
Authors: Susanti Suseno Novie , Ungkari Marti Dewi , Barlian Rafael Gani
Published: October 2023

This study aims to find out what strategy should be used by UKM Rai SJ Leather by using SWOT analysis, where the Balanced Scorecard is used as the basis for strategy formulation. Informants were selected based on the consideration that the person was considered to know the most about various information related to the company's operational strategy. In this study, the authors use primary data and secondary data. The research method used is a qualitative method. Data collection techniques using library research, interviews, and internet studies. The data analysis technique was carried out by means of data reduction, data presentation, and verification. The results showed that after weighting using the IFAS matrix with a value of 1.95 and the EFAS matrix with a value of -0.5, the Rai SJ Leather SME is located in quadrant two. The strategy that must be used in quadrant two is concentric diversification by utilizing strengths to overcome various threats. The strategy from the growth and learning perspective is that SMEs must recruit human resources who have knowledge and abilities in the field of technology and quality control; in the internal business process perspective, the strategy that must be carried out is to make new innovations, the strategy from the customer perspective is to increase the brand to be recognized more widely, the strategy on a financial perspective is to increase revenue.
Keywords: Balanced Scorecard, Business Strategy, SWOT Analysis.
Effect of Zinc Fortification on Growth attributes, Yield Attributes and Soil Available Nutrients of Babycorn
Authors:   Department of Agronomy123, Tamil Nadu Agricultural University, Coimbatore-03, G Tamil Amutham , r Karthikeyan ,   Department of Agronomy123, Tamil Nadu Agricultural University, Coimbatore-03, N Thavaprakaash ,   Department of Agronomy123, Tamil Nadu Agricultural University, Coimbatore-03
Published: October 2023

A field experiment was conducted to determine the effect of zinc fortification on growth attributes, yield attributes and soil-available nutrients of babycorn. The treatments comprised of T1: control, T2: ZnSO4 at 25 kg ha-1 as soil application, T3: ZnSO4 at 37.5 kg ha-1 as soil application, T4: Foliar spray at 0.5% on 20 and 40 DAS, T5: Foliar spray at 1.0% on 20 and 40 DAS, T6: T2+T4, T7: T2+ T5, T8: T3+ T4, T9: T3+ T5. Growth parameters viz., plant population, leaf area index, days to first tasseling, days to first cob initiation and days to first harvest were significantly influenced by combined application of ZnSO4 to soil @ 37.5 kg ha-1 with foliar spray @ 1.0% on 20 DAS and 40 DAS. Dry matter production of babycorn was significantly higher in soil application of ZnSO4 @ 37.5 kg ha-1 with foliar spray at 0.5% on 20 and 40 DAS. Increased yield attributes such as number of cobs/plant, cob and corn length, cob and corn weight, cob and corn girth were observed higher with combined application of ZnSO4 @ 37.5 kg ha-1 to soil with foliar spray @ 0.5% at 20 and 40 DAS. Soil available nutrient status of NPK was not significantly influenced by Zn fertilization. However, higher availability of zinc nutrient after harvest of the crop was obtained with application of ZnSO4 @ 37.5 kg ha-1 in soil with foliar spray of 0.5% at 20 and 40 DAS.
Science students’ literacy and faculty members’ perspective toward nanotechnology: Is it needed in 21st century education?
Authors: Ibrohim Ibrohim , Kusumaningrum Irma Kartika , Hamimi Erti , Putra Wira Eka , Utomo Joko , Kundariati Maisuna , Hajar Maya Umi , Bin Nik Malek Nik Ahmad Nizam
Published: October 2023

Nanotechnology has been applied in various fields of human life today. However, efforts to integrate nanotechnology into the curriculum in Indonesia are insufficient, including in higher education. The research was conducted to reveal the level of literacy of science students and faculty member at university level in Indonesia. The research method in this study is a cross-sectional survey design with a total of 63 science lectures and 388 students from 22 universities in Indonesia who are participated in this study. The literacy level of student and lecturer’s perspective was analyzed from research instrument that consists of 16 questions test items in multiple choice forms. Descriptive statistics method used to analyze literacy level of science’s students and descriptive analysis used to analyze faculty member perspective toward nanotechnology. This study found that the highest literacy level toward nanotechnology in student university level was chemistry students (43,789) and the lowest is biology students (29,579). It means that the understanding of nanotechnology, which is more directed to the field of biology is not widely studied by the student’s in university level. Faculty members have perspective about nanotechnology are not integrated nanotechnology into classroom. They believed that nanotechnology is an important issue that must be directly available with curriculum system in education. This study contributes to primary research about nanotechnology implementation in education as a part of the need of 21st century.
Forum Kewaspadaan Dini Masyarakat (FKDM) as a Strategy Instrument for Countering Radicalism and Extremism in North Purwokerto District, Banyumas Regency, Indonesia
Authors: Bintarsari Nuriyeni Kartika , Yamin Muhammad , Miryanti Renny , Anwar Soni Martin , Darmawan Arif , Fitrah Elpeni
Published: October 2023

Objective: This study aims to assess the effectiveness of the Forum Kewaspadaan Dini Masyarakat (FKDM) as a strategic instrument for countering radicalism and extremism in North Purwokerto District, Banyumas Regency, Indonesia.

Methods: Utilizing a qualitative research approach, the study engaged in thorough observations and active involvement with various stakeholders. Data were analyzed through thematic analysis, supported by in-depth interviews and Focus Group Discussions (FGDs).

Findings: The study found that FKDM demonstrates a strong commitment to mitigating the risks associated with radicalism and extremism. However, it faces key challenges, including insufficient budget allocations and difficulties in coordinating among multiple agencies.

Conclusions: The study concludes that while FKDM shows promise as a tool for countering radicalism and extremism, successful implementation requires sufficient resource allocation and effective inter-agency collaboration. The findings contribute to the limited body of research on the operational efficiency of FKDM in specific regional settings and offer insights for policy-making.
Safety and risk assessment of methanol extract of Ocimum gratissimum leaf on Wistar rats
Authors: Dasofunjo K  , Odu F  , Nnamani VI  , Ejim CI  , Usin SG  , Osim ME  , Timothy FM  , Enyam J  , Mgbe PT  , Wilson AO
Published: October 2023

Methanol extract of Ocimum gratissimum was investigated for its effects on Wistar rats using some kidney and liver functional indices as ‘markers’. Twenty- eight (28) albino rats weighing 180-200 g was randomly assigned into four groups (A-D) of seven animals each. Animals in groups B-D was orally administered on daily basis with 0.5 ml of the extract corresponding to 50,100 and 200 mg/kg body weight of the extract respectively for 14 days while those in the control group received orally 0.5 ml of distilled water. Rats in all the groups were sacrificed 24 hours after the completion of their respective doses and serum, liver and kidney tissue samples were collected for biochemical parameters. The extract significantly (p<0.05) decreased serum, liver and kidney ALP, AST and ALT. The extract also significantly (p<0.05) reduced serum urea, uric acid and creatinine. Contrastingly, the extract significantly (p < 0.05) increase in serum albumin, globulin and total protein respectively when compared with the normal control at 50, 100 and 200 mg/kg body weight respectively. The effect of administration of the extract on serum Na+, K+, Cl- and HCO3- ions shows a significant (p<0.05) decrease when compared with the normal control with the exception of an increase in K+ ion concentration at 200 mg/kg bwt when compared with the normal control. The biochemical alterations from this result suggest that the extract of Ocimum gratissimum may induce hyponatremia and hypokalaemia at high dosage possibly by altering the Na + /H – exchanger with aldosterone without causing assault or injury to the hepatic, nephrotic and /or tubular function.
Covid 19 Salgınının Kentsel Gıda Sistemleri ve Tarımsal İşgücü Bağlamında Sosyal, Mekânsal, Yönetsel Etkileri
Authors: YILDIRIM Uygar Dursun
Published: October 2023

Son yıllarda Dünyada ve Türkiye’de salgın, iklim değişikliği, deprem, ekoloji ve gıda alanında yaşanan kriz ve şoklar her geçen gün kır ve kent mekanları üzerindeki etkisini artırmaktadır. Özellikle doğal, ekolojik felaketler ve salgın hastalıkların kentsel gıda sistemlerini ve tarımdaki aile üreticilerini ve mevsimlik/göçmen işçiler gibi farklı grupları nasıl etkileyeceği sorusu kamuoyunun ve akademik araştırmaların önde gelen başlıklarından biri haline gelmektedir. Bu çalışmada 2020 Mart ayından itibaren Türkiye’de etkili olmaya başlayan Covid 19 Salgını’nın gıda sistemleri içinde yer alan küçük üreticiler ve mevsimlik işçiler üzerindeki etkilerine odaklanılmıştır. Çalışmada salgının etkilerinin yoğunlaştığı ve fındık hasadının başladığı 2020 Eylül ayında Sakarya’nın Karasu ve Kocaali İlçelerinde nitel yöntemle yapılan saha araştırmasından elde edilen veriler kullanılmıştır. Araştırmada salgın yönetimi esnasında başvurulan sosyal izolasyon ve diğer kısıtlama tedbirlerinin tarımda işgücü hareketliliği ve ürün piyasaları üzerinde çeşitli kırılganlıklar yarattığı saptanmıştır. Tarımdaki üretim ve emek süreçlerinin farklı kır ve kent mekanları arasındaki işbölümüne bağımlı hale gelmesi bu tip kırılganlıkların ortaya çıkmasında etkili olmaktadır.
Türkiye Azerbaijan Economic Relations: Bilateral Revealed Comparative Advantage Perspective
Authors: AKAY Atiye Beyhan
Published: October 2023

Türkiye is attempting to strengthen its economic relations through regional and global cooperations. Türkiye desires to boost trade volume, diversify trade markets, and become a major player in the area through bilateral or multilateral collaboration with South Caucasus and Central Asian nations, with whom it shares linguistic and cultural affinities. After Azerbaijan declared its independence in 1991, Türkiye established economic relations with Azerbaijan and signed a Preferential Trade Agreement in 2020, in order to take the cooperation to a higher level. The economic relations of the two nations are analyzed in terms of international trade in this study, with the goal of increasing bilateral trade volume and liberalizing trade. Countries are assessed using fundamental macroeconomic variables, and their comparative advantages in bilateral trade are established. Using the bilateral revealed comparative advantage index, the study examined the nations' comparative advantages and export shares by product group. The findings of the study allow for a comparison of product groupings with comparative advantage with the products covered by the Preferential Trade Agreement, as well as a sense of the agreement's potential to enhance trade volume.
Development of Hit The Mouse Games Using Javascript
Authors: Devi Perwitasari Ika , Hendrawan Jodi
Published: October 2023

The idea of this game is that this game includes arcade games that are played traditionally which can be found in night markets or shopping centers such as Plazas. Arcade games are games that aren't focused on a story and can be entertaining when you're bored. This is done to analyze the needs that will be used to design and make a mole game, starting with determining the theme, game title, and programming language used to develop the game. The tools used include hardware and software. the application can run according to what has been designed by the author. The researcher tested the application by playing several times with different IP addresses as a test material for the application, whether the test was successful or not. Based on the results of making a game application for hitting moles, there are several conclusions that researchers can give, namely: a. This game can involve the player's concentration and become cognitive therapy, because the rats come out one by one from the ground to be hit. b. This game can only be played by one person. c. The making of the game Mole Hit has worked well according to the design that was made and compiled at the beginning of the game design, using the Javascript programming language.
The impact of non dental glass fiber addition against tensile strength pre-polymerized fiber reinforced composite
Authors: Hadianto Eko , Sofiana Nurfika , Yusuf Moh
Published: October 2023

Background: Composite resin is one of the most used materials in dentistry because of the simplicity and high aesthetic value. One of the varieties of composite resin is prepolymerized composite resin. Some research show that prepolymerized composite resin has relatively low mechanical strength. Therefore fiber needs to be added in prepolymerized composite resin. The aim of this research is to find out the effect of adding non dental glass fiber into tensile strength fiber reinforced composite.

Method: This research used true experimental method with post test only control group design, there are two groups, the first one is prepolymerized composite resin with additional non dental glass fiber. The data has been tested with parametric independent T-test.

Result: The result showed the average flexural strength of prepolymerized composite resin without additional non dental glass fiber was 10.6625 Mpa, while the prepolymerized composite resin + non dental glass fiber was also 18.2263 Mpa. Independent T-test showed the p value = 0.000

Conclusion: The conclusion of this research is that prepolymerized resin + non dental glass fiber has higher tensile strength than composite resin without additional non dental glass fiber, thus it can be used as alternative choice applied in dentistry.
Current global trends in the study of etiology, pathogenesis, diagnosis and treatment of chronic endometritis
Authors: Kosei N.V. , Tatarchuk T.F. , Vetokh N.V. , Vasylchenko L.A.
Published: October 2023

The article is devoted to the analysis of scientific information on the problem of chronic endometritis (CE) today. CE is a mysterious, multifactorial disease, the etiology, pathogenesis, and optimal treatment of which have not yet been definitively determined.Endometrial inflammation is a complex part of its physiology that is finely regulated by the balance between pro- and anti-inflammatory mechanisms and is involved in all reproductive events.Chronic inflammation stimulates hormone-independent cell proliferation, suppression of apoptosis processes, activation of tumor growth factors, invasion, tumor angiogenesis, and neovasculogenesis. The transformation of the inflammatory process occurs due to chronic leukocyte infiltration. The chronic inflammatory process provokes the development of dystrophic changes in the epithelium, the infiltration of the stroma by leukocytes and the destruction of intercellular contacts, which, in turn, leads to a decrease in the hermetic function of the epithelium and a violation of the differentiation of epithelial cells during the process of metaplasia. This process is accompanied by a disturbance of local humoral immunityMetabolic disorders such as diabetes, dyslipidemia, hypertension, and obesity have also been found to overactivate the immune system, causing leukocyte activation with increased numbers of their proinflammatory phenotypes, which explains the susceptibility to chronic inflammatory diseases.Infectious agents should no longer be considered the sole cause of CE. Any condition that disrupts the balance of the immune system can lead to temporary, recurrent, or persistent CE. The last one can have various dangerous clinical and paraclinical consequences.To date, there are no recommendations that would provide proper analysis or treatment of endometrial inflammation. Therefore, the definition of clinical signs for the assessment of the global risk of development of CE for female patients is relevant. The clinical assessment of the patient’s condition should take into account her age, lifestyle, body mass index, blood pressure, atopy, stress factor, signs of chronic inflammation, as well as history of diseases mediated by inflammation.Further research into this pathological condition and the development of effective ways to prevent it are particularly relevant, which can contribute to the improvement of women’s reproductive health and their fertility.
Studying the discipline of free choice «Ultrasound Diagnostics in Obstetrics and Gynaecology»
Authors: Ancheva I.A. , Gladchuk I.Z. , Mokriienko E.M. , Movlyanova N.V. , Lazor N.V.
Published: October 2023

Today, in the education system, an important opportunity for higher education applicants is the right to form an individual educational trajectory according to the relevant qualification level. Higher education seekers have received not only academic mobility but also the opportunity to study disciplines to consciously choose their specialty and study it more deeply. The skills of ultrasound diagnostics increase the professional level of a doctor of any specialization and open wide diagnostic possibilities.The article reveals the peculiarity of studying one of the subjects of free choice by medical higher education applicants on the basis of Odesa National Medical University – “Ultrasound Diagnostics in Obstetrics and Gynaecology”. The adaptation of the educational process in a mixed format with the possibility of using digital learning technologies and mastering professional skills on ultrasound machines of different classes is described. In the course of studying the discipline, the necessary basic digital skills of using an ultrasound scanner and knowledge of the main visualization modes, adjustment principles, as well as sets of functional capabilities inherent in all modern devices are formed.The method of presentation of theoretical information and the use of case scenarios during the discussion of clinical tasks with mandatory visualization of ultrasound video recordings is described. The applicants’ digital skills are directly related to the course being studied and are necessary to master the proposed professional field. The possibility of learning using the latest medical equipment in combination with the use of digital learning tools and video resources contributes to the acquisition of professional competence and the formation of responsibility and interest of students. In the process of training manual scanning skills, the doctor’s thinking and the ability to analyze and interpret the received ultrasound data are formed. Practical classes help to discuss the most interesting issues for this specific group of higher education applicants in a comfortable and trusting environment. The use of a combined approach in the presentation of the material, the author’s style and the format of the transfer of professional skills by experienced teachers who are engaged in constant practical activities motivate, improve the training process and give a high result.
metodologia da problematização no ensino de ética profissional na enfermagem
Authors: Correia Ana Carolina Gonçalves , Melo Ernani Viriato de
Published: October 2023

O estudo abordou a utilização da Metodologia da Problematização no ensino de Ética Profissional em um Curso Técnico em Enfermagem. A Metodologia da Problematização é uma metodologia ativa, que utiliza problemas da realidade para construção do conhecimento. O objetivo geral deste estudo foi investigar a contribuição da Metodologia da Problematização para o ensino de Ética Profissional em um Curso Técnico em Enfermagem. Foi elaborado um Manual Didático, como material de apoio para o professor, orientando as etapas para desenvolvimento da Metodologia da Problematização, trabalhando a reflexão sobre problemas éticos na Enfermagem. O estudo incluiu pesquisa experimental, com aplicação do Manual Didático e levantamento de dados, por meio de questionário com estudantes. Os resultados mostraram que a Metodologia da Problematização aproximou os conteúdos teóricos com a prática profissional, ao utilizar problemas da realidade, permitindo maior participação dos estudantes nas aulas e contribuindo para o aprendizado do conteúdo. Por meio deste estudo, foi possível perceber que a Metodologia da Problematização contribuiu significativamente para o ensino de Ética Profissional na Enfermagem.
Fine powders obtaining of biologically active products by freeze-drying method
Authors:   “All-Russian Scientific Research Institute of Poultry Processing Industry” — the branch of FSC ARRTPI (ARSRIPPI), Moscow region, Russia, Agafonychev Valery , Maksimov Alexander ,   “All-Russian Scientific Research Institute of Poultry Processing Industry” — the branch of FSC ARRTPI (ARSRIPPI), Moscow region, Russia, Romanenko Yuri ,   “All-Russian Scientific Research Institute of Poultry Processing Industry” — the branch of FSC ARRTPI (ARSRIPPI), Moscow region, Russia
Published: October 2023

Control algorithm has been suggested by freeze-drying process. This algorithm gives the possibility to effect purposefully on freeze-dried product indices such as porosity, final moisture content, fraction of frozen water and shrink- age rate. The algorithm ensures obtaining the product fine powder.
ANALISIS IMPLIKATUR PERCAKAPAN ANTARA PENJUAL DAN PEMBELI DI PASAR SUNGAI PINANG DALAM SAMARINDA
Authors: Bila Salsa , Nia Paramitha Rosadi  , Purwanti
Published: October 2023

Abstrak

Pragmatik mempelajari tentang suatu maksud dari tuturan ataupun kalimat.. Implikatur percakapan merupakan implikatur yang diketahui oleh sebagian orang saja guna mengetahui konteks tuturan saja. Salah satu prinsip berbahasa dalam bidang pragmatik adalah prinsip kerja sama atau maksim kerja sama Grice yang membagi prinsip-prinsip yaitu, maksim kuantitas, maksim kualitas, maksim relevansi, dan maksim pelaksanaan. Pasar merupakan wadah ataupun tempat masyarakat melakukan transaksi jual beli. Pasar tradisional adalah pasar yang masih menerapkan sistem tradisional untuk kegiatan transaksi jual belinya, pasar ini bertransaksi secara langsung, dan kebanyakan yang dijual adalah barang berupa kebutuhan pokok. Penelitian ini merupakan bentuk penelitian kualitatif bersifat deskriptif dengan metode mengumpulkan data berdasarkan studi lapangan dan kepustakaan. Penelitian ini dilakukan guna melihat penerapan implikatur percakapan berdasarkan bentuk maksimnya di pasar Sungai Pinang Dalam, Kota Samarinda. Penentuan sampel yang kami ambil dilakukan dengan teknik penetapan sampel secara acak mengambil sebanyak kurang lebih 10 data/sampel dalam transaksi antara penjual dan pembeli. Pengumpulan data dilakukan dengan menggunakan teknik simak catat dan teknik simak bebas. Metode dalam penyajian ini berupa penyajian sebuah narasi. Analisis data dikumpulkan dala enam tahap yaitu, mengumpulkan data, mencatat data, menganalis data, mengidentifikasi data, pengecekan data, dan menyimpulkan hasil penelitian. Diperoleh gambaran semua jenis klasifikasi tindak tutur serta implikatur percakapan terpenuhi. Konklusi diperoleh dari analisis data yang diperoleh selama penelitian berlangsung.
PREVENTION OF SUICIDAL ACTIVITY USING VIRTUAL REALITY INTERVENTIONS
Authors:   Taras Shevchenko National University of Kyiv, Shevchuk Olha , Krupelnytska Liudmyla ,   Taras Shevchenko National University of Kyiv
Published: October 2023

Advancements in technology within the reality–virtuality (RV) continuum offer novel avenues for addressing mental health and psychosocial support, supplementing traditional approaches. Consequently, it is imperative to investigate how these immersive interactions affect potential beneficiaries. Goal. This article is devoted to the analysis of immersive technologies potential, specifically virtual reality (VR), in the context of suicide prevention. Methods. The authors investigate the psychological effects of using VR technologies as a preventive intervention for suicidal behavior. It is organized within the framework of an experimental procedure designed according to Solomon's plan, in which the independent variable (IN) was watching a 360° video in VR glasses, and the dependent variables (DVs) were factors associated with suicidality, namely: emotional affect (positive and negative), hopelessness, and indicators of individual well-being levels. The Questionnaire on Positive and Negative Affects (OPANA), Beck's Hopelessness Scale, and the "Modified BBC Subjective Well-Being Scale (BBC-SWB)" were used to measure these indicators. The experimental hypothesis of our study: watching a 360° video in virtual reality glasses has an effect on parameters associated with suicidality. Results. In this article, we highlight the results of the comparison of the control and experimental groups regarding the impact on the measured psychological effects by analyzing the indicators before and after the use of the intervention through the mediation of immersive technologies. The findings demonstrate statistically significant enhancements in positive affect, psychological, physical, and subjective well-being within the experimental group compared to the control group. Trends toward improvement were also observed in measures of negative affect and relationship well-being, although they did not reach statistically significant levels. The hopelessness score improved in both groups, which may indicate a general ameliorative effect on the participants in such an experimental procedure. Conclusions. Our study reveals that a one-time intervention mediated by immersive technologies, namely viewing a 360° video in VR glasses, contributed to the improvement of measurable psychological effects of indicators associated with suicidality and can potentially be used as a means of preventing suicidal behavior. The experimental hypothesis of our study was confirmed. In the future, a comprehensive study of the obtained results regarding the effect of preliminary testing and expansion of meaningful interpretation of the data is necessary; as well as related studies of the long-term effect, series of interventions, specifics of the context of the video presented in the virtual space and alternative forms of prevention and impact on measurable indicators.
Medical service of railways during the Great Patriotic War
Authors: Semenov Mikhail
Published: October 2023

Based on statistical data, the analysis of the dynamics of the development of the medical network of the Transport Medical and Sanitary Administration of the People's Commissariat of Railways during the Great Patriotic War was carried out. Summary data on the scale of patient care in outpatient and inpatient medical institutions of the People's Commissariat of Railways are presented. The relatively high-quality level of departmental healthcare of railways is indicated. Sanitary and anti-epidemic activities on the railway are highlighted. The conclusion is made about the significant contribution of railway healthcare to the preservation of life and health of the population.
CPNE3 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: October 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that copine 3, encoded by CPNE3, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. CPNE3 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of CPNE3 in primary tumors was correlated with patient recurrence-free survival. Modulation of CPNE3 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
ZMPSTE24 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: October 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that zinc metallopeptidase STE24, encoded by ZMPSTE24, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. ZMPSTE24 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of ZMPSTE24 in primary tumors was correlated with patient overall and recurrence-free survival. Modulation of ZMPSTE24 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Tindakan perundungan dalam dunia pendidikan
Authors: Rizal Saiful
Published: October 2023

Perundungan atau bullying merupakan salah satu bentuk kekerasan yang terjadi pada remaja. Bullying merupakan bentuk perilaku kekerasan dengan adanya kekuasaan untuk menyakiti seseorang atau sekelompok secara verbal, fisik, maupun psikologis korban. Dampak yang didapatkan oleh korban bullying adalah memiliki berbagai masalah mental dan keluhan kesehatan fisik dukungan sosial memiliki peranan penting sebagai pelindung korban bullying dari penyakit psikis dan penyakit fisik. Selain itu, faktor kesibukan, ketidakpedulian atau ketidaktahuan keluarga turut menjadi faktor penghambat.
Machine Learning in Drug Safety Monitoring: Enhancing Pharmacovigilance Efforts
Authors: Egon Kaledio , KARL LETHO
Published: October 2023

I. IntroductionA. Definition of PharmacovigilancePharmacovigilance is a vital field in healthcare that involves the continuous monitoring of adverse drug reactions (ADRs) to existing medicines. Its primary objective is to ensure the safety and efficacy of pharmaceutical products used by patients. This involves the collection, assessment, understanding, and prevention of adverse effects, whether they are known or potential. The aim is to minimize risks and maximize the benefits of medical treatments.B. The Importance of Drug Safety MonitoringThe significance of drug safety monitoring cannot be overstated. ADRs can be harmful, sometimes even life-threatening, and can lead to significant healthcare costs. Ensuring the safety of patients is not only an ethical obligation but also a legal requirement for pharmaceutical companies and regulatory authorities. Monitoring and addressing ADRs help in improving the quality of healthcare and contribute to overall public health.C. Role of Machine Learning in Enhancing PharmacovigilanceMachine learning plays a pivotal role in enhancing pharmacovigilance efforts. Here's how:Early Detection of ADRs: Machine learning algorithms can analyze vast amounts of data from various sources, such as electronic health records, social media, and medical literature, to identify potential ADRs. By detecting adverse events early, healthcare professionals and regulatory bodies can take prompt actions to mitigate risks.
SEC61A1 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: October 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that SEC61 translocon subunit alpha 1, encoded by SEC61A1, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. SEC61A1 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of SEC61A1 in primary tumors was correlated with patient overall and recurrence-free survival. Modulation of SEC61A1 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Machine Learning and Chronic Disease Management: Customizing Care for Better Outcomes
Authors: Egon Kaledio , ROSINSKI JULIA
Published: October 2023

I. IntroductionA. Definition of Chronic DiseasesChronic diseases are long-term, often lifelong health conditions that persist over an extended period. These conditions typically progress slowly and may not have a definitive cure. Common chronic diseases include heart disease, diabetes, cancer, chronic respiratory diseases, and arthritis.B. Prevalence and Impact of Chronic DiseasesChronic diseases are a major global health concern. They account for a significant portion of morbidity and mortality worldwide. The impact of chronic diseases is not limited to physical health but also affects quality of life, healthcare costs, and economic productivity. The burden of these diseases is rising, particularly in aging populations.C. Importance of Customized Care in Chronic Disease ManagementCustomized care, also known as personalized or precision medicine, is an approach that tailors healthcare interventions to individual patients based on their unique characteristics, genetics, lifestyle, and preferences. In the context of chronic disease management, customized care is crucial because it recognizes that each patient's experience and needs are different. This approach can lead to more effective treatment and improved patient outcomes.D. The Role of Machine Learning in Healthcare on "Machine Learning and Chronic Disease Management: Customizing Care for Better Outcomes":Machine learning has emerged as a powerful tool in healthcare, offering the potential to transform how chronic diseases are managed. By analyzing vast amounts of patient data, machine learning algorithms can identify patterns and trends that would be difficult for humans to discern. This technology can play a significant role in customizing care for chronic disease management in the following ways:Predictive Analytics: Machine learning can predict disease progression, identify individuals at high risk of developing chronic conditions, and even forecast potential complications. This allows healthcare providers to intervene early and personalize preventive measures.Treatment Recommendations: Machine learning models can analyze patient data to suggest personalized treatment plans, medications, and lifestyle modifications. This can result in more effective and efficient care tailored to each patient's needs.Remote Monitoring: Machine learning enables continuous monitoring of patients through wearable devices and remote sensors. It can detect subtle changes in health status and provide real-time alerts to healthcare providers, helping them customize interventions as needed.Data Integration: Machine learning can integrate and analyze diverse data sources, including electronic health records, genomics, patient-reported outcomes, and environmental data. This holistic view of the patient allows for a more comprehensive and individualized approach to chronic disease management.
ATP5PB is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: October 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that ATP synthase peripheral stalk-membrane subunit b, encoded by ATP5PB, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. ATP5PB mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of ATP5PB in primary tumors was correlated with patient distant metastasis-free and recurrence-free survival. Modulation of ATP5PB expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Materi Ajar Membaca berbasis E-Book bagi Mahasiswa
Authors: Zulhafizh
Published: October 2023

Ketersedian materi ajar membaca sangat diperlukan dalam pembelajaran masa depan. Dalam pembelajaran masa kini pengajar dituntut dapat lebih kreatif untuk menciptakan pembelajaran yang menarik, namun tetap memperhatikan karakterisitik budaya bangsa. Oleh karena itu, perlu dilakukan pengembangan materi ajar membaca menguntai literasi humanis berbasis e-book. Permasalahan yang mendasar saat ini minimnya ketersediaan materi ajar membaca yang terintegrasi secara digital. Masalah dalam penelitian ini berkaitan dengan kebutuhan materi ajar membaca humanis berbasis e-book. Tujuan penelaahan ini adalah menemukan kebutuhan materi ajar membaca menguntai berbasis e-book. Metode penelitian yang dilakukan menggunakan metode deskriptif. Data penelitian ini adalah hasil angket, wawancara dan hasil refleksi. Data-data tersebut bersumber dari responden penelitian yang diperoleh secara acak. Analisis data dilakukan secara reflektif interaktif dengan menggunakan TagCword dan AntCont. Hasil penelitian mendeskripsikan bahwa mahasiswa dan dosen di provinsi Riau membutuhkan pengembangan materi ajar membaca berbasis e-book. Konten muatan materi yang dibutuhkan adalah materi yeng terintegrasi dengan Tunjuk Ajar Melayu. Orintasi teks yang dibutuhkan oleh mahasiswa dan dosen di provinsi riau adalah teks yang merefleksikan sikap dan perilaku orang Melayu.
Nỗ lực chống biến đổi khí hậu của ta đã thật sự hiệu quả chưa?
Authors: La Viet-Phuong , Nguyen Minh-Hoang
Published: October 2023

Mặc dù vẫn còn những nghi ngờ về sự thay đổi khí hậu trong một số tài liệu nghiên cứu, sự đồng thuận mạnh mẽ trong cộng đồng khoa học vẫn xác định rằng nhiệt độ bề mặt toàn cầu đã tăng trong vài thập kỷ gần đây. Biến đổi khí hậu, chủ yếu là kết quả của hoạt động con người, đang trở thành một trong những thách thức toàn cầu cấp bách nhất của thời đại chúng ta. Trong thập kỷ vừa qua, con người đã thực hiện những nỗ lực đáng kể để đối phó với cuộc khủng hoảng biến đổi khí hậu và đã đạt được những ảnh hưởng nhất định trong việc chống lại biến đổi khí hậu và tạo ra nhận thức sâu rộng về hậu quả của nó. Tuy nhiên, câu hỏi tiếp tục đặt ra là liệu chúng ta đang đi đúng hướng để giải quyết cuộc khủng hoảng này một cách hiệu quả hay không? Bài tiểu luận này sẽ xem xét những thành tựu trong cuộc chiến chống biến đổi khí hậu, nhận thức ngày càng tăng về tác động của nó, mức độ nghiêm trọng ngày càng tăng của khủng hoảng khí hậu và liệu hành động của chúng ta đã đi đúng hướng chưa hay liệu chúng ta có cần xem xét lại cách tiếp cận của mình hay không.
MENGATASI BULLYING MELALUI PENDIDIKAN KARAKTER
Authors: Novrika Eqy
Published: October 2023

Sistem Pendidikan Nasional Indonesia senantiasa berubah seiring dengan perjanal anan hidup masyarakat Indonesia serta tuntutan zaman. Pada masa mengisi kemerdekaan dengan pembangunan, pendidikan nasional berperan memfasilitasi. Selanjutnya masa ref ormasi, dunia pendidikan juga terkena perubahan sesuai dengan tuntutan-tuntuan era refo rmasi. Reformasi mengendaki suatu tatanan berbangsa dan bernegara yang menunjung tin ggi kemanusiaan, demokrasi, penegakan hukum, keadilan, dan perwujudan masyarakat m adani/ sipil. Reformasi juga menguatkan adanya kebutuhan sosok manuisa yang bertakwa dan berakhlak mulia, berjiwa patriotis, dan memiliki semangat nasionalisme, dan juga m enguasai IPTEK, yang dituntut dapat memfasilitasi terwujudnya sosok manusia dan masy arakat yang reformis. Bersamaan dengan perubahan yang dihadapi bangsa pada era dan p asca era reformasi muncul tuntutan globalisasi yang makin merasuk dan menerpa dengan keras terhadap seluruh aspek kehidupan, kondisi ini menuntut untuk segera diantisipasi ol eh bangsa Indonesia dengan mempersiapkan tenaga pembangunan yang tangguh dan ber wawasan global.
RBFOX3 is differentially expressed in central nervous system metastasis in human breast cancer.
Authors: Mamoor Shahan
Published: October 2023

Metastasis to the brain occurs in a significant fraction of patients with breast cancer (1-3). We mined published RNA-sequencing and microarray data (4, 5) to compare primary and metastatic tumor transcriptomes for the discovery of genes associated with brain metastasis in humans with metastatic breast cancer. We found that RNA binding fox-1 homolog 3, encoded by RBFOX3, was among the genes whose expression was most different in the brain metastases of patients with metastatic breast cancer as compared to primary tumors of the breast. RBFOX3 mRNA was present at increased quantities in brain metastatic tissues as compared to primary tumors of the breast. Expression of RBFOX3 in primary tumors was correlated with patient recurrence-free survival. Modulation of RBFOX3 expression may be relevant to the biology by which tumor cells metastasize from the breast to the brain in humans with metastatic breast cancer.
Wireless Communication Technologies: A Comprehensive Review and Future Prospects
Authors: Johnson Danny
Published: October 2023

Wireless Communication Technologies: A Comprehensive Review and Future Prospects
A protocol for a scoping review of psychedelic interventions to alleviate psychological suffering in populations coping with end-of-life issues
Authors: Kratina Sarah , Lo Chris , Schwartz Robert , Strike Carol , Jopling Sydney , Nayfeh Ayah , Rush Brian
Published: October 2023

ABSTRACTBackground: Psychedelic substances are increasingly recognized for their therapeutic potential to ease psychological suffering linked to end-of-life issues. However, amid renewed scientific and public interest, policy remains restrictive. Existing reviews have made progress in synthesizing the results of studies of psychedelic interventions, especially psilocybin, and particularly with regard to their outcomes related to anxiety and depression, long-term effects and safety. Despite this progress, there has been a wide range of both substances and therapeutic approaches in the use of psychedelic interventions in end-of-life populations, of which there has been a paucity of research undertaken to learn from this variety. Aim: The aim of this scoping review is to comprehensively explore the literature on the range of therapeutic psychedelic interventions that have been reported in populations coping with life-threatening illness and the end-of-life. Methods: We will follow Arksey and O’Malley’s (2005) framework for scoping reviews while incorporating updated methodological guidance. The Preferred Reporting Items for Systematic Review and Meta-Analyses extension for scoping reviews (PRISMA-ScR) guideline will be used to organize the search and identification of research focusing on psychedelic interventions, psychological suffering, and end-of-life issues. Data extracted from selected studies will cover intervention details, participant characteristics, measured outcomes, theorised mechanisms, and sociocultural contextual factors.Contribution: The insights gained from this review will be used to inform discussions about the role of psychedelic interventions in populations coping with end-of-life concerns.Ethics and Dissemination: This scoping review does not require ethics approval. Results will be disseminated through peer-reviewed publications and conferences as well as shared with stakeholders.