bluuebunny/crossref_metadata_2025 huggingface dataset:
Application of the Heritage Urbanism Model on the Example of the Renovation and Revitalisation of the Town Parks of Opatija
Authors: Vahtar-Jurković Koraljka
Published: April 2024

Opatija, the first climatic health resort on the eastern coast of the Adriatic and the elegant center of the tourist riviera of the same name in Croatia, is characterized by an impressive identity and a unique image of the town formed in the unity of urbanism, architecture and park architecture in the late 19th and early 20th centuries. Town authorities strive to protect, restore and revitalize their rich park heritage, especially town parks and promenades. Therefore, Opatija's town parks were considered as a case study in the scientific project Heritage Urbanism (HERU), which defined general and special models for the renovation and revitalization of cultural-historical heritage. This paper provides an overview of appropriate models of renovation and revitalization of all ten Opatija's town parks using the HERU method, based on established factors of their identity and criteria for preserving their values, improving their condition and possible new interventions in them. It is concluded that it would be necessary to apply a certain combination of 14 general and special models. The results of the research are applicable in urban planning and tourist development planning in Opatija and other similar tourist resorts in Croatia and abroad.
Role of Ultrasound Investigation in Acute Achilles Tendon Rupture
Authors: Bolarinwa Bukola Veronica , Moloney Darren P. , Doyle Evin , Bayer Thomas
Published: April 2024

Objectives: This study aims to investigate the reliability of ultrasound in differentiating between partial and complete TA ruptures. It also aims to establish whether ultrasound findings of TA ruptures are in accordance with intraoperative findings.Method: The authors identified all cases of Achilles tendon rupture treated operatively in a unit over the course of the year. Charts were reviewed retrospectively to identify whether cases had undergone ultrasound. Intraoperative findings and ultrasound reports were compared.Results: 49 cases of Achilles tendon rupture were diagnosed and treated operatively. 23 cases underwent ultrasound of the tendoachilles preoperatively. 8 were reported as partial ruptures. All cases were found to be complete rupture intraoperatively. The sensitivity of ultrasound in establishing completeness of tendoachilles rupture is 63.5%.Conclusion: Ultrasound differentiation of complete vs partial ruptures is not a useful differentiator.
Immune checkpoint inhibitor colitis, a rising issue in targeted cancer therapy era: A literature review
Authors: Adiwinata Randy , Tandarto Kevin , Tanadi Caroline , Waleleng Bradley Jimmy , Haroen Harlinda , Rotty Linda , Gosal Fandy , Rotty Luciana , Hendratta Cecilia , Lasut Pearla , Winarta Jeanne , Waleleng Andrew , Simadibrata Paulus , Simadibrata Marcellus
Published: April 2024

Research advances in the oncology treatment field have led to the widespread use of immunotherapy. The usage of immune checkpoint inhibitor (ICI) has improved the survival of cancer patients with metastases. This has also led to the rapidly expanding indications for ICI use. However, ICI usage may lead to toxicity, which may be immune-related, in different organ-specific targets. The immune-related adverse events (irAEs) of ICI may lead to increased morbidity, decreased quality of life, and early termination of ICI. The clinical manifestations of irAEs in the gastrointestinal system are variable, ranging from self-limited to life-threatening or fatal events. In this review article, we would like to focus on discussing ICI-induced colitis, which is one of the most common ICI irAEs in the gastrointestinal tract.
Transseptal approach in endoscopic sphenoidotomy
Authors: Karpishchenko S. A. , Vereshchagina O. E. , Arustamyan I. G. , Stancheva O. A.
Published: April 2024

INTRODUCTION. Isolated sphenoid sinus disease is a rare condition due to the topographic location of the sinus. In complicated cases and the occurrence of a chronic course, the main method of treatment is surgical cure. There are different approaches to the main sinus, the most effective and safest is endoscopic endonasal sphenotomy. However, in cases of anomalies or disorders of the development of the sphenoid sinuses, as well as the need for combined operations, the transeptal approach may be the method of choice.

OBJECTIVE is to evaluate the effectiveness and security of the proposed access.

METHODS AND MATERIALS. A prospective analysis was carried out of 52 patients who underwent surgical treatment of isolated sphenoiditis at the Clinic of Otorhinolaryngology of the Pavlov State Medical University in the period from 2018 to 2023.

RESULTS. In 5 cases, the sphenoid sinus was opened by transseptal approach. As a result of the analysis of the two approaches, no statistically significant differences were found.

CONCLUSIONS. Our surgical interventions with transseptal approach in patients with minor sphenoid sinuses, impaired course of the internal cerebral artery, as well as the need for simultaneous correction of the nasal septum revealed the advisability and effectiveness of approach in such situations, as well as its safety in relation to neurovascular structures.
Modern concept of treatment of patients with ventral hernias
Authors: Romashchenko P. N. , Kurygin Al. A. , Semenov V. V. , Prudieva S. A. , Mamoshin A. A.
Published: April 2024

INTRODUCTION. The relevance of treating patients with hernias of the anterior abdominal wall is beyond doubt, since the incidence of the disease is on average 5 people per 1000, and hernioplasty itself is one of the most common operations in a general surgical hospital. However, the relapse rate remains quite high. There remains a debate about the choice of surgical option; the issues of prevention and treatment of pain syndrome, as well as tactics for managing patients with a complicated postoperative period, remain unresolved.

The OBJECTIVE was to evaluate the effectiveness of the modern concept of treating patients with ventral hernias and to substantiate the principles for choosing a hernioplasty technique.

METHODS AND MATERIALS. The study is based on the results of treatment of 1938 patients operated on at the Faculty Surgery Clinic named after S.P. Fedorov Military Medical Academy in the period from 2015 to 2022. Both open and endovideosurgical options for surgical interventions were performed for isolated umbilical hernias or in combination  with diastasis of the rectus muscles, hernias of the white line of the abdomen, inguinal and postoperative hernias, including reduction of the volume of the abdominal cavity.

RESULTS. During the study, an algorithm for the treatment of patients with ventral hernias was developed, various options for perioperative pain relief were proposed, and the tactics for treating infectious and purulent complications were substantiated.

CONCLUSION. A specialized surgical hospital must perform all possible options for both traditional and endovideosurgical hernioplasty, use innovative options for pain relief in the perioperative period, and apply modern methods for diagnosing and treating postoperative complications in order to provide personalized medical care.
Enhancing Current Density and Specific Capacitance through Tensile TEMPO, Bacterial Cellulose and Polypirrole Nanocomposites
Authors: Yunus Syukri , Manurung Muhammad Fajar Ruhud , Aulia Aulia , Arief Yanuar Zulardiansyah
Published: April 2024

The researchers developed a bio-composite film material that serves as a substitute for metal. The materials used are TEMPO ((2,2,6,6-tetramethylpiperidine-1-oxyl)), Bacterial Cellulose, and Polypyrrole (Ppy). This research aimed to increase the material's current density and specific capacitance values using the drawing method. Composite nanomaterials are made by oxidizing BC (Bacterial Cellulose) with TEMPO. The resulting TOBC (TEMPO Bacterial Cellulose) material was mixed with Ppy using the in situ method. The mixture is then drawn wet—measurement of current density and capacitance using Cyclic Voltammetry (CV) Testing. The current density and specific capacitance results increased by 542.74% and 754.79% after drawing the nanocomposite material. It is directly proportional to the effects of characteristic testing, which includes SEM, XRD, and FTIR. As a result of the withdrawal of the polypyrrole, it will be more evenly distributed in the composite material, absorbing and coating the nata de coco. The researchers concluded that when the TOBC/Ppy fibers are straighter and denser, they achieve higher current density and capacitance values.
Filmer, R. (2023). Patriarca. Una defensa del poder natural de los reyes contra la antinatural libertad del pueblo (J. Udi, Trad.). Universidad Nacional de Quilmes
Authors: Fernández Vega José
Published: April 2024

Los orígenes del patriarcado se remontan a los comienzos del pensamiento filosófico, por no mencionar el religioso, y los cuestionamientos a esa noción vienen tomando cada vez más impulso a lo largo del mundo en los últimos años. Un reflejo académico de ese movimiento es la relectura crítica de los clásicos de la filosofía a la luz del avance de los feminismos y las consideraciones de género. Juliana Udi brinda en su introducción a Patriarca un análisis exhaustivo de un clásico de la filosofía política seguido de una traducción elegante y cuidadosamente anotada. Con ello intenta un regreso a las fuentes modernas del patriarcado político para identificar sus fundamentos teóricos y su contexto histórico, pero también para discutir desde una perspectiva de género su persistencia social en nuestros días.
Disfunções ribossômicas na Anemia de Diamond-Blackfan
Authors: Silva Felipe Henrique da , Oliveira Elton Gonçalves de , Silva Graziela Maria da , Santos José Antônio Figueiredo , Carmo Larissa Kécia da Silva do , Assis Elisangela Vilar de , Figueiredo Francisco José Gonçalves , Lira Rafaelle Cavalcante de
Published: April 2024

Objetivo: Identificar na literatura científica a associação entre distúrbios ribossomais e sua implicação na anemia de Diamond-Blackfan. Métodos: Trata-se de uma revisão integrativa com artigos publicados entre 2008 a 2023, no idioma português, inglês e espanhol e com texto completo disponível. Utilizou-se como questão norteadora: Qual a relação entre as disfunções nos ribossomos e a Anemia de Blackfan-Diamond? A pesquisa bibliográfica foi realizada em outubro de 2023, sendo realizada buscas nas bases de dados: BVS e PUBMED, por meio dos Descritores em Ciências da Saúde (DeCS): Ribossomos e Anemia de Diamond-Blackfan, e pelo Medical Subject Headings terms (MeSh terms): dysfunction, ribosome e anemia, diamond blackfan, realizando-se combinações com os termos com o uso do operador booleano “AND”. Resultados: 13 artigos que obedeceram aos critérios de inclusão e exclusão, nos quais os mecanismos subjacentes da DBA foram explorados, destacando-se questões genéticas e moleculares. Considerações finais: A pesquisa destaca a complexidade dos mecanismos de biogênese ribossômica, genes reguladores, proteína p53, associando-os a produção de células sanguíneas e na caracterização fenotípica da doença. O entendimento da interligação desses aspectos regulatórios é imprescindível para diagnóstico e tratamento, abrindo perspectivas para terapias mais direcionadas no futuro.
Effects of two-phase treatment with functional appliances versus one-phase treatment with pre-molar extraction in Class II div 1 monozygotic twins: A case study
Authors: Geçer Rumeysa Bilici , Dursun Derya
Published: April 2024

The aim of the study was to compare the skeletal, dental, or soft-tissue outcomes of a one-phase camouflage treatment with pre-molar extraction versus a two-phase treatment with combined twin-block high-pull headgear followed by fixed orthodontic treatment in monozygotic twins. 12-year-old male monozygotic twins presented to the dental clinic with complaints about their anterior teeth. Cephalometric analysis of the patients revealed skeletal Class II malocclusion and a long facial type. Extraoral examination of the patients revealed incompetence of lip seal and a convex profile. In Patient 1, the use of a high pull headgear combined with a twin block to correct skeletal anteroposterior and vertical malocclusions with growth modification and then fixed orthodontic treatment was planned. Patient 2 did not comply with the treatment, complaining that the use of the device could cause esthetic problems and difficulties in use. Therefore, camouflage treatment with extraction of four pre-molars was planned as another treatment option for Class II patients in Patient 2. With the camouflage treatment, the patient continued to grow normally. The combined treatment with twin block and a high pull occipital headgear resulted in inhibition of maxillary growth and a reduction in the severity of the skeletal Class II malocclusion, but the mandibular changes were similar in both patients at the end of treatment. Despite the different treatment modalities, both twins achieved a Class I canine-molar relationship and ideal overjet and overbite. Patients can close their lips with improved soft-tissue profiles. The criteria for the choice of treatment depend entirely on the requirements of the patient.
Multi-contrast echo-planar imaging sequence (Echo-planar imaging mix) in clinical situations demanding faster MRI-brain scans
Authors: Ganesh Viswanadh Kalaparti Sri Venkata , Kamepalli Hari Kishore , Sharma Dev Prakash , Thomas Bejoy , Kesavadas Chandrasekharan
Published: April 2024

Objectives:

The excellent resolution offered by magnetic resonance imaging (MRI) has a trade-off in the form of scan duration. The purpose of the present study was to assess the clinical utility of echo-planar imaging mix (EPIMix), an echo-planar imaging-based MRI sequence for the brain with a short acquisition time.

Materials and Methods:

This was a retrospective observational study of 50 patients, who could benefit from faster MRI brain scans. The T1, T2, fluid attenuated inversion recovery, diffusion-weighted imaging (DWI), and T2*/susceptibility-weighted imaging sequences were acquired, conventionally and with EPIMix. Conventional and EPIMix images were assessed by two radiologists for overall quality, motion, and susceptibility artifacts and scored on a Likert scale. The scores given for conventional and EPIMix images were compared. The diagnostic performance of EPIMix was also assessed by the ability to detect clinically relevant findings.

Results:

The acquisition time for conventional MRI was 11 min and 45 s and for EPIMix 1 min and 15 s. All EPIMix images were sufficient for diagnostic use. On assessment of the diagnostic performance, it was excellent for ischemic and hemorrhagic strokes. Smaller lesions, lesions adjacent to bone, and post-operative tumors were difficult to identify. Moderate to perfect agreement (Kappa values 0.41–1) was seen between radiologists for all categories except skull base, calvarial, and orbital lesions. Image quality, artifact assessment showed excellent interobserver agreement (>90%) for the scores. All EPIMix images showed reduced motion artifacts. The EPIMix-DWI was comparable to conventional-DWI in terms of quality and artifacts. The remaining sequences showed reduced quality and increased susceptibility.

Conclusion:

The EPIMix has a significantly reduced acquisition time than conventional MRI and could be used instead of conventional MRI in situations demanding faster scans such as suspected acute ischemic or hemorrhagic stroke. In other clinical scenarios, it could help tailor the MRI examination for each patient.
Can New Structure of RET Inhibitors Capable of Suppressing Resistant in Non-Small-Cell Lung Cancer?
Authors:   Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou, Jiangxi 341000, PR China, Shen Jiayi , Chen Liping ,   Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou, Jiangxi 341000, PR China, Song Yulan ,   Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou, Jiangxi 341000, PR China, Chen Sheng ,   Jiangxi Chiralsyn Biological Medicine Co., LTD, China, Guo Wei ,   Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou, Jiangxi 341000, PR China, Li Yongdong ,   Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou, Jiangxi 341000, PR China
Published: April 2024

In 2012, RET rearrangements are observed in 1-2% of Non-Small-Cell Lung Cancer (NSCLC) patients and result in the constitutive activation of downstream pathways normally implied in cell proliferation, growth, differentiation and survival. Several compounds have been reported, including some traditional kinases inhibitors and the discovery of some new structure of natural products. Cabozantinib and vandetanib are multikinase inhibitors have been explored in the clinic for NSCLC patients. As a result of the nonselective nature of these multikinase inhibitors, patients had off-target adverse effects. Then, the discovery and clinical validation of highly potent selective RET inhibitors such as pralsetinib and selpercatinib demonstrating improved effificacy and a more favorable toxicity profile. However, acquired resistance mediated by secondary mutations in the solvent-front region of the kinase (e.g. G810C/S/R) becomes a major challenge for selective RET inhibitor therapies. In this review, we will highlight typical RET inhibitors developed during these years and provide a reference for more potential RET inhibitors exploration in the future.
Calcium Influx Pathways in Breast Cancer: Opportunities for Pharmacological Intervention
Authors:   Apollo College of Pharmacy, Anjora, Durg, India, Sonwani Hari
Published: April 2024

Numerous cellular processes, including the release of neurotransmitters and the contraction of muscles, are largely triggered and regulated by Ca2+ inflow via Ca2+ permeable ion channels. In addition, Ca2+ influx regulates cellular migration and proliferation, two mechanisms linked to cancer. This study focuses on calcium influx in breast cancer cells and discusses how future drugs for breast cancer therapy may be pharmacological modulators of particular Ca2+ influx channels. Certain breast tumors have altered expression of particular calcium permeable ion channels. Such alterations may occasionally be connected to the prognosis and subtype of breast cancer. These days, models both in vivo and in vitro have assisted in identifying particular Ca2+ channels that are crucial for the growth and invasiveness of of cancerous breast cells. Nonetheless, additional research is still needed to fully understand several features of Ca2+ influx in breast cancer. These include figuring out the processes behind the changed expression and the best treatment plan to target breast cancer cells via particular Ca2+ channels. In the upcoming ten years, research should concentrate on the function of Ca2+ influx in mechanisms other than the migration and proliferation of breast cancer cells.
Unveiling the Potential of OsRuvB DNA Helicases in Enhancing Salinity Stress Tolerance in Chickpea
Authors:   Department of Molecular Biology, Biotechnology and Bioinformatics CCS Haryana Agricultural University, India, Kumar Deepak , Lakra Nita ,   Department of Molecular Biology, Biotechnology and Bioinformatics CCS Haryana Agricultural University, India, Sharma Parul ,   Department of Botany and Plant Physiology, CCS Haryana Agricultural University, India, Luhach Annu ,   Department of Molecular Biology, Biotechnology and Bioinformatics CCS Haryana Agricultural University, India, Zaid Abbu ,   Department of Botany, GGM Science College, Cluster University Jammu, India
Published: April 2024

Chickpea (Cicer arietinum L.) is a self-pollinated true diploid (2n=2x=16) cool season leguminous crop that ranks second among food grain legumes after soybean. It grows under a wide range of climatic conditions and is highly sensitive to salt stress. In the present study, transgenic chickpea plants (var. HC-1) carrying OsRuvB gene were screened for salt stress. Putative transformants were screened at an early stage through PCR amplification using gene specific primers and a transformation frequency of 36.2% was observed. Physio-biochemical analysis of selected T2 transgenic plants subjected to 100 mM salt stress showed that transgenic plants were able to maintain higher chlorophyll content, relative water content, cell viability, proline content, Na+/K+ content, catalase and peroxidase activity compared to the wild type plants. Whereas electrolytic leakage and lipid peroxidation were relatively less as compared to the wild type plants under 100 mM stress. Among all transgenic lines, line 8 performed well with respect to all the parameters studied and can be taken further for the development of transgenic chickpea plants for salt stress tolerance.
Impact of COVID-19 on the Strategy for the Prevention and Elimination of Hepatitis B and Hepatitis C
Authors:   Clinic for Infectious Diseases, University Clinical Centre of the Republic of Srpska, Banja Luka, the Republic of Srpska, Bosnia and Herzegovina, Verhaz Antonija
Published: April 2024

The COVID-19 pandemic, since SARS-CoV2 was discovered in December 2019, has resulted in significant morbidity and mortality. Since then, several countries have witnessed the collapse of the health care system due to the great need to treat patients with COVID-19. At the global level, drastic measures have been taken to combat the spread of the virus. However, these measures have led to disruptions in other aspects of health care, diagnosis and treatment of other diseases and conditions. There is also a stalemate in achieving the ambitious goal set by the World Health Organization to eliminate viral hepatitis as a threat to public health by 2030. Hepatitis B and C are chronic conditions with a significant global burden, and COVID-19 has slowed or stopped many hepatitis elimination programs.
Tetrazole functionalization: A new strategy toward stable ion-solvating polymer electrolytes for alkaline water electrolysis
Authors: Serhiichuk Dmytro , Rajappan Sinu C. , Krishnan Yogeshwaran , Xia Yifan , Kraglund Mikkel Rykær , Hansen Heine Anton , Jensen Jens Oluf , Aili David
Published: April 2024

A new class of ion-solvating membranes based on a tetrazole functionalized vinyl copolymer is introduced. The membranes are prepared from poly(styrene-co-acrylonitrile), by converting the acrylonitrile groups to tetrazole pendants in a one-step click-type [3+2] cycloaddition reaction, and the tetrazole content is controlled by adjusting the acrylonitrile content of the starting material. Due to the weak acidity of the tetrazole pendants, nearly complete ionization to the corresponding tetrazolides occurs when the membranes are equilibrated in aqueous KOH. Model system studies and DFT simulations show that this suppresses the electrophilicity of the functional group, which results in a material with remarkable stability with no signs of degradation after nearly 4000 h in 25 wt.% KOH at 80 °C. The electrolyte-imbibed membranes support ion conductivity up to 90 mS cm-1 in 15 wt% KOH at 80 °C, which allows for stable electrolysis operation for 600 h with performance characteristics comparable to that of the conventional Zirfon separator.
Polyglutamine (PolyQ) Diseases: Navigating the Landscape of Neurodegeneration
Authors: Tenchov Rumiana , Sasso Janet , Zhou Qiongqiong Angela
Published: April 2024

Polyglutamine (polyQ) diseases are a group of inherited neurodegenerative disorders caused by expanded cytosine-adenine-guanine (CAG) repeats encoding proteins with abnormally expanded polyglutamine tract. A total of nine polyQ disorders have been identified, including Huntington's disease, six spinocerebellar ataxias, dentatorubral pallidoluysian atrophy (DRPLA), and spinal and bulbar muscular atrophy (SBMA). The diseases of this class are each considered rare, yet polyQ diseases constitute the largest group of monogenic neurodegenerative disorders. While each subtype of polyQ diseases has its own causative gene, certain pathologic molecular attributes have been implicated in virtually all of the polyQ diseases, including protein aggregation, proteolytic cleavage, neuronal dysfunction, transcription dysregulation, autophagy impairment, and mitochondrial dysfunction. Although animal models of polyQ disease are available helping to understand their pathogenesis and access disease-modifying therapies, there is neither a cure nor prevention for these diseases, with only symptomatic treatments available. In this paper, we analyze data from the CAS Content Collection to summarize the research progress in the class of polyQ diseases. We examine the publication landscape in the area in effort to provide insights into current knowledge advances and developments. We review the most discussed concepts and assess the strategies to combat these diseases. Finally, we inspect clinical applications of products against polyQ diseases with their development pipelines. The objective of this review is to provide a broad overview of the evolving landscape of current knowledge regarding the class of polyQ diseases, to outline challenges, and evaluate growth opportunities to further efforts in combating the diseases.
ĐẶC ĐIỂM VỎ PHONG HOÁ TRÊN ĐÁ GRANODIORIT PHỨC HỆ BẾN GIẰNG – QUẾ SƠN KHU VỰC NAM ĐÔNG, THỪA THIÊN HUẾ
Authors: Thủy Nguyễn Thị , Lê Duy Đạt , Trần Hữu Tuyên
Published: April 2024

Bài báo giới thiệu đặc điểm cơ bản của vỏ phong hoá phát triển trên đá granodiorit phức hệ Bến Giằng – Quế Sơn ở khu vực Nam Đông, Thừa Thiên Huế, bao gồm tính phân đới, thành phần hoá học – khoáng vật, thành phần hạt và tính chất cơ lý. Kết quả cho thấy các đá granodiorit ở khu vực bị phong hoá mạnh, tạo tầng phong hoá dày 8–10 m và phân đới tương đối rõ. Vỏ phong hoá thuộc kiểu SiAlFe với hàm lượng nhôm cao (24,5%), kiềm rất thấp (0,1% CaO va 0,1% Na2O) và chỉ số phong hoá hoá học cao (CIA: 91,9). Sản phẩm phong hoá ở các đới chủ yếu là đất sét và đất sét pha, hàm lượng nhóm hạt sét – bụi trong đới phong hoá hoàn toàn là 65,7–87,8% và giảm dần theo chiều sâu. Khoáng vật sét chủ yếu gồm kaolinit, illit và allophan/imogolit. Thành phần hạt và các tính chất cơ lý của đất (độ ẩm, khối lượng thể tích tự nhiên, độ rỗng và độ bão hoà) có xu hướng tăng dần khi xuống sâu. Ngoài ra, vào mùa mưa, các giá trị này đều gia tăng, đặc biệt khi có mưa lớn và kéo dài, khiến cho đất mất cân bằng và thường xuyên gây trượt lở trên mái dốc dọc các tuyến giao thông của địa bàn.
COVID-19 Associated Mucormycosis(CAM) in a Tertiary Care Hospital inBangalore: A Case-Series Report
Authors: TS Ranganath , M Murthy Deepak , HC Vani , SG Kishore , George Riya
Published: April 2024

Background While the country is still grappling with the COVID-19 pandemic it finds itself in yet another crisis of COVID-19 Associated Mucormycosis CAM. India being the second largest populated country with diabetes mellitus has the highest cases of mucormycosis in the world.Objective This study was undertaken to help find more specific causes for increased number of mucormycosis cases in the second wave when compared to the first wave. Methodology The present study was conducted among active mucormycosis patients admitted in Victoria hospital from 24th May to 4th June 2021. A detailed case history data collection tool was prepared. Information was collected about their demographic profile symptoms COVID-19 treatment details comorbidities risk factors investigations and treatment details in their understandable language. A total of 63 subjects were interviewed and the process involved collecting information from the subjects and their attenders assessing case files and interaction with treating doctors. Later the data was exported into MS office excel and analyzed with IBM SPSS V20.0.Results Mean age of the subjects was 49.4 years 23 years - 76 years. Diabetes mellitus 5688.8 was the dominant predisposing factor 49 77.7 had poor glycemic control and in 23 44 patients among them hyperglycemia was diagnosed during the evaluation of mucormycosis. The main causes that appear to be aiding mucormycosis to infect the patients with COVID-19 are hyperglycemia hypoxia antibiotic and steroid use not being vaccinated for COVID-19 neutropenia deranged ferritin levels along with social factors like poor hygiene overcrowding and lower socio-economic status.Conclusion It is important to do whole genomic sequencing of SARS-COV2 virus to explore any possible causative role of it in these patients. Judicious use of steroids only when necessary and when prescribed along with strict control of blood glucose in COVID-19 patients who are known diabetics and pre-diabetics is necessary.nbsp
Masonry infill in structural analysis: effects on seismic performance
Authors: Doye S. D.
Published: April 2024

In structural analysis, masonry infill is commonly regarded as a non-structural component. However, understanding the true behavior of a structure requires incorporating the effects of masonry infill in seismic evaluations. This paper reviews the effects of masonry infill on seismic performance through analyses including pushover analysis, time history analysis, response spectrum analysis, linear static analysis, and eigenvalue analysis. Ten research papers were reviewed, covering different aspects of masonry infill effects on structures of varying configurations and seismic zones. Results indicate that including masonry infill reduces the fundamental time period of vibration and storey displacement while increasing the base shear compared to bare frame structures. This comprehensive review underscores the importance of considering masonry infill in structural analysis to enhance seismic performance.
Effects of oleogels (alpha-linolenic acid plus beeswax) extracted
supplementation for approaching the therapeutic food ingredient: in vitro model
Authors: Issara U. , Teerapattarakan N.
Published: April 2024

The dietary fatty acid intake for vascular disease has been highlighted for a decade. This
study aimed to determine the effect of palmitic acid and fatty acid-incorporated beeswax
(oleogels: OG) supplementation on anti-atherosclerotic effects through vascular smooth
muscle cell (VSMC) activity. The A7r5 cells were cultured, cells were treated with three
treatments, including 1) control, 2) palmitic acid (PA), and 3) alpha-linolenic acid (ALA)
+ beeswax, ratio 1:1 (OG) at different concentrations of 0, 25, 50 and 100 μM for 48 hrs.
Cell proliferation, cell apoptosis, wound repair, and relative quantity of mRNA level of
inflammatory cytokines and angiogenetic transcription factors were determined. The
results showed there was a significantly reduced VSMCs proliferation with concentrationdependent (p < 0.05). In the presence of OG at 100 μM, the wound area had healed after
24 hrs (59.2%) compared to PA (28.0%) group treatments. OG and PA supplementation
significantly up-regulated eNOS and VEGF but down-regulated the TNF-α, CRP, CD36,
iNOS, and NF-κB mRNA expression levels, while PA was a contrasting pattern (p <
0.05). Therefore, supplementation of OG reduced the pro-inflammatory effects of
inflammatory cytokines in macrophages and induced VEGF expression in VSMCs,
contributing to anti-atherosclerotic effect.
Advanced Technologies for Volatile Organic Compound (VOC) Emission Treatment: An Overview
Authors: Li Yizhe
Published: April 2024

This paper presents a comprehensive overview of various advanced technologies employed in the treatmentof volatile organic compounds (VOCs), which are crucial pollutants in industrial emissions. The study explores different methods, including direct combustion, thermal combustion, catalytic combustion, low-temperature plasma purification, photocatalytic purification, membrane separation, and adsorption methods. Each technology is critically analyzed for its operational principles, efficiency, and applicability under different conditions. Special attention is given to adsorption concentration and catalytic combustion parallel method, highlighting its efficiency in treating low-concentration, high-volume VOC emissions. The paper also delves into the advantages and limitations of each method, providing insights into their effectiveness in various industrial scenarios. The study aims to offer a detailed guide for selecting appropriate VOC treatment technologies, contributing to enhanced environmental protection and sustainable industrial practices.
Analysis of Standards Establishment for the Testing of Electrical Appliances
Authors: Xie Xiaobin
Published: April 2024

As science and technology continue to develop, power equipment has become an indispensable part of industrial production and daily life. Whether it is the precise automation machinery utilized on production lines or the convenient electrical appliances found in households, their functionality relies heavily on electrical technology. Nonetheless, without stringent safety and performance assurances, these devices could potentially endanger lives and property. Thus, this paper explores the development strategy for establishing a standardized system within the electrical testing service industry, aiming to ensure safety and reliability.
DEMANDA OBSTÉTRICA NOS PRONTO-SOCORROS: ESTRATÉGIAS DE INTERVENÇÃO NA ATENÇÃO PRIMÁRIA.
Authors: Silva Victor Hugo Góes , pereira Matheus santos samaritano
Published: April 2024

DEMANDA OBSTÉTRICA NOS PRONTO-SOCORROS: ESTRATÉGIAS DE INTERVENÇÃO NA ATENÇÃO PRIMÁRIA.
Introdução :Transição epidemiológica elevou mortes por acidentes, exigindo mais atendimento pré-hospitalar. Norm
PERFIL EPIDEMIOLÓGICO DAS URGÊNCIAS POR LESÕES AUTOPROVOCADAS EM CRIANÇAS E ADOLESCENTES NO BRASIL
Authors: Queiroz Bianca Hévelyn de Lacerda , Pereira Isaque Vinícius Silva
Published: April 2024

Introdução: A lesão autoprovocada é a violência que o indivíduo comete contra si mesmo, a qual pode ocorrer com ou sem intenção suicida. Este tipo de comportamento vem aumentando exponencialmente em c
A “licença parental” no direito do trabalho: por uma aplicação do princípio da isonomia e uma nova percepção de gênero.
Authors: Reges Petrúcio Araújo
Published: April 2024

No Brasil, as desigualdades que se expressam de diversas formas nas relações de gênero, consagrando assimetrias entre direitos e deveres parentais. Nesse contexto, os sujeitos de direito, em razão do gênero, exercem o direito ao afastamento na constituição das relações afetivas parentais a partir de aspectos qualitativos notadamente desiguais, como o lapso temporal concedido distintamente a cada pessoa, em razão do gênero. Desse modo, o presente estudo se propõe a analisar importantes aspectos históricos, sociais e jurídicos da inefetividade da equidade de gênero nas relações parentais, diante dos significados que elucidam no fenômeno em questão. atual desses princípios e a sua aplicação nas mais diversas esferas do direito, mas especificamente. Para tanto, realizamos uma pesquisa qualitativa, mediante a análise de fontes documentais – decisões proferidas pelo Poder Judiciário e as Normas Jurídicas que estabelecem relação com a temática, e a análise de fontes bibliográficas – pesquisas científicas que contribuíram aos objetivos estabelecidos à pesquisa, a partir de perspectiva interdisciplinar. Por fim, ressaltamos que a igualdade se constitui de um princípio constitucional que historicamente estabelece significados distintos aos deveres e direitos conferidos à pessoa humana, em razão do gênero, de modo que os estudos das teorias Queer e as contribuições de Judith Butler foram fundamentais nesse percurso analítico acerca da (in)efetividade da equidade à pessoa humana em razão do gênero no Brasil, explorando o fenômeno da desigualdade nos afastamentos e licenças concedidos a partir do legítimo exercício do direito da parentalidade, ao que denominamos de “licença parental”.
Uma análise comparada da busca por status da Turquia e as consequências para seu papel na ordem regional no Oriente Médio
Authors: Monteiro Vlademir
Published: April 2024

Como a busca por status afeta o papel da Turquia na ordem regional do Oriente Médio? Essa é a questão de pesquisa deste artigo. O objetivo é explicar a variação dos papéis a partir das estratégias de gerenciamento de identidade que o país adotou em diferentes momentos. Para tal, faz-se uma comparação entre o período da Guerra Fria e a fase mais recente da política externa turca. Argumenta-se que suas preferências regionais são formuladas em sintonia com a busca por status, condicionando-o ao exercício de tarefas que caracterizam um papel específico na ordem regional.
REACT.js E GOOGLE MAPS NA INSERÇÃO DE MELHORIA DE BUSCA: ANÁLISE DE IMPACTO NA USABILIDADE E EFICIÊNCIA NA BUSCA NO RAMO ALIMENTÍCIO NA WEB
Authors: Lira Antônio Vinicius Lima , Lima Edilson Carlos Silva , Caridade Elda Regina de Sena
Published: April 2024

A evolução das tecnologias Web desencadeia o surgimento de frameworks e bibliotecas que visam melhorar o trabalho realizado por quem as utiliza. Para maximizar a satisfação dos clientes e criar soluções dentro dos padrões atuais do mercado, as empresas devem adaptar seus produtos, com foco em soluções baseadas na web, para melhorar a usabilidade e o fluxo de uso. Portanto, este artigo apresenta um estudo de caso real, onde a empresa humansoft revisou uma de suas principais soluções, o humanportal, utilizando uma das tecnologias web mais recentes e amplamente utilizadas, o React.js. React.js é um framework especialmente desenhada para lidar com a camada de visualização de aplicações web e a sua utilização em contexto empresarial, nomeadamente no sector da restauração. Com este processo, verificou-se um real grau de satisfação dos clientes, destacando-se a maior flexibilidade e facilidade de utilização do produto, permitindo assim a otimização e formação dos procedimentos de gestão de recursos humanos. Partindo dessas premissas, o objetivo deste projeto é criar uma API utilizando o framework React.js (baseado em Java script) e utilizamos web services do Google Maps. A pesquisa realizada utiliza uma abordagem que incorpora estudos de caso e, quanto à classificação técnica da coleta de dados, foram realizados experimentos, visando uma análise mais abrangente do problema em estudo. Essa estratégia visa aprofundar a compreensão do tema, tornando-o mais esclarecedor e esclarecedor.

Palavras-chave: Framework, React.js, Api, Google aps.
A COEXISTÊNCIA DA TECNOLOGIA 5G NO MERCADO COM OS PROVEDORES DE INTERNET LOCAIS
Authors: Lima Caylon Bruno Bentes , Lima Edilson Carlos Silva , Sá Marcos José dos Passos
Published: April 2024

A quinta geração de tecnologia móvel (5G) emergiu como um avanço tecnológico que promete revolucionar a conectividade e velocidade, apresentando oportunidades inovadoras para a Internet das Coisas (IoT) e para pessoas com alcances limitados em zonas distantes. O 5G vai além do seu predecessor, o 4G, ao oferecer velocidades de transferência de dados significativamente mais rápidas, menor latência e uma capacidade maior de conectar simultaneamente um vasto número de dispositivos. No entanto, há diversos países, empresas e indivíduos que expressam dúvidas em relação ao 5G conseguir substituir por completo os provedores locais e a internet de banda larga. Esse artigo, tem como base a metodologia de estudo de caso, quanto a escolha do objetivo de estudo e qualitativa, quanto a classificação à natureza da pesquisa, buscando explorar a inabilidade da tecnologia 5G de substituir completamente os provedoras de internet (ISPs), concluindo que essa substituição não deve ocorrer devido a uma combinação de fatores técnicos, econômicos, regulatórios e sociais. Em muitos casos, a coexistência desses provedores é mais provável do que uma substituição completa, pois ambos podem atender a diferentes necessidades e preferências dos consumidores.

Palavras-chave: Tecnologia, 5G, ISPs.
DESENVOLVIMENTO DE UMA API REST COM NEST JS PARA UM JOGO NO ESTILO LUDO
Authors: Silva Israel de Jesus Lopes , Lima Edilson Carlos Silva , Caridade Elda Regina de Sena
Published: April 2024

A Periodontite Padrão Molar Incisivo é classificada como uma patologia crônica multifatorial tendo associação com um biofilme disbiótico. Essa doença é caracterizada pela perda clínica de inserção de 3mm ou mais em dois ou mais sítios, presença de bolsas periodontais profundas e perda óssea radiográfica nos incisivos e primeiros molares. Além de acometer indivíduos sistemicamente saudáveis. O objetivo desse trabalho é relatar um caso clínico de periodontite padrão molar incisivo, em que foram feitos procedimentos cirúrgicos em associação com a antibioticoterapia. Relato de caso: a paciente do presente estudo foi diagnosticada com periodontite padrão molar incisivo, a qual realizou o tratamento na clínica escola de Odontologia do Centro Universitário UNDB. A terapia foi realizada através de procedimentos cirúrgicos envolvendo raspagem subgengival além de raspagem supragengivais, em conjunto com o uso de antibióticos sistêmicos desde a primeira sessão. Logo, a partir desse trabalho foi perceptível a melhora dos parâmetros clínicos da paciente, como diminuição do índice de sangramento e da profundidade à sondagem, favorecendo assim um adequado prognóstico.

Palavras-chave: Doenças periodontais, Saúde bucal, Periodontia.
DESENVOLVIMENTO E TECNOLOGIAS POR TRÁS DO APLICATIVO NADD PARA PLATAFORMA ANDROID E IOS USANDO FLUTTER
Authors: Souza Eric Silva de , Lima Edilson Carlos Silva , Mesquita Leonardo de Castro
Published: April 2024

No contexto atual, observa-se tecnologias e aplicativos em diversos setores, surgindo e tendo diversas funcionalidades diferentes, simplificando o dia a dia das pessoas. Mesmo diante de diversas tecnologias, algumas organizações, entidades e empresas possuem muito trabalho manual preenchendo diversas papeladas todo dia, consequentemente, perdendo assim o controle com o aumento de registros. Este trabalho propõe discutir e desenvolver um aplicativo de gerenciamento de registros para o Núcleo de Apoio ao Docente e Discente (NADD) da Universidade Ceuma, utilizando flutter e spring boot. Através de uma pesquisa exploratória, com base em fontes primárias e abordagem qualitativa dos dados revelou que o aplicativo é funcional e de fácil utilização e que atendeu bem a demanda de registrar os dados, porém, apresentou ausência de informações importantes.

Palavras-chave: flutter, Nadd, aplicativo.
Visions of an Industrial Lakefront Utopia in the Calumet Frontier: City Planning and Repatriation in an Ethnic Mexican Colonia , 1900–1934
Authors: Aguilar Emiliano
Published: April 2024

ABSTRACT: Nestled at the southern tip of Lake Michigan, East Chicago, Indiana, became the site of massive-scale industrialization in the early twentieth century. This effort, in turn, fueled massive-scale migration into the region. During the 1919 Great Steel Strike, the steel industry began to recruit thousands of ethnic Mexicans to serve as steelworkers and laborers across the region. Institutional and community forces segregated the ethnic Mexican community into a portion of the city called Indiana Harbor. Within this neighborhood, individuals worked to forge a community complete with institutions such as Catholic churches, a Spanish-language newspaper, and businesses. However, city planners and potential residents came to believe that the community represented a problem for the city's growth. In the 1930s, members of East Chicago's American Legion Post 266 orchestrated a repatriation campaign to alleviate the financial burden of public relief. The campaign targeted the ethnic Mexican community, whose presence was labelled as undesirable and a potential source of job competition in the region's exhausted economy.
The image of the common enemy of the USSR and NATO in the English-language cinema of the Cold War period
Authors: Nazarov Maxim Alekseevich
Published: April 2024

The author extensively examines the plots of films from the Cold War period in English-language cinema, focusing on the representation of the “common enemy” and the Soviet side. The research aim is to identify how this theme evolved during periods of détente and escalation of the Cold War in the 1980s, exploring the images and plots used in films. The study analyzes a range of films and TV series as sources of this theme, including James Bond films, the series “The Man from U.N.C.L.E.” and “The A-Team”, as well as works by directors such as Stanley Kubrick, Don Siegel, and John Mackenzie. The scientific novelty lies in analyzing plots and characters that have received little attention in Russian cultural studies. New sources have been introduced into the academic discourse, and the theme of the article is novel, shedding new light on the topic of cultural confrontation between the USSR and the Western bloc, revealing plots that reshape perceptions of the representation of the Soviet side in Anglo-American cinema. The author concludes that British and American directors did not consider the USSR as absolute evil, leading to the creation of a narrative trope of a common enemy hostile to both NATO and the Soviet Union.
Peculiarities of the use of interactive video materials in the formation of foreign language sociocultural competence among primary school pupils
Authors: Parfenova Svetlana Olegovna , Kruglova Irina Valerievna
Published: April 2024

The aim of the study is to theoretically substantiate the possibility of forming foreign language sociocultural competence among younger schoolchildren during English language lessons in primary school with the use of interactive video materials. The paper examines the features of the use of interactive video materials in teaching foreign languages, including with the purpose of forming foreign language sociocultural competence among primary school pupils. The scientific novelty of the study lies in creating a methodology for using interactive video materials in order to form foreign language sociocultural competence among primary school pupils. As a result of the study, a series of lessons / extracurricular activities on sociocultural topics were developed, including methodological recommendations, lesson notes and thematic interactive video materials themselves, which can be used by teachers during lessons or extracurricular activities in order to form foreign language sociocultural competence among primary school pupils.
Semantic-syntactic properties of the deverbal relative ‘исходя из’ (‘based on’)
Authors: Zarubina Elena Sergeevna
Published: April 2024

The aim of the study is to determine the degree of grammaticalization of the deverbal relative ‘исходя из’ (‘based on’). The paper examines the lexical meaning of the relative and the presence of the functional meaning in dictionaries and works dedicated to prepositional units. The paper explores the meaning of the construction with ‘исходя из’, the semantics of the right (dependent) and left (main) components of the construction and outlines features indicative of the transition of this unit into a prepositional one. The study is novel in that it is the first to describe the semantic and syntactic functioning and to determine the degree of grammaticalization of the deverbal relative ‘исходя из’, which is a language unit that does not belong to the core of the preposition category. As a result, the study finds that the semantics of the deverbal relative, the meaning of the construction that expresses cause-effect relationships of phenomena reflecting various aspects of intellectual activities (denoted by verbs) and phenomena subject to interpretation (denoted by nouns), as well as the broadening of usage contexts are indicative of the grammaticalization of the examined unit.