bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy and safety of endovascular image-guided treatment of pseudoaneurysms of the celiac artery: clinical and organizational aspects
Authors: Goloshchapov-Aksenov R S , Kicha D I , Frolov S K , Gurin A V
Published: October 2019

Aim. To present the immediate results of the assessment of the effectiveness and safety of the use of endovascular technologies for the treatment of hemorrhagic complications of pseudoaneurysms of the visceral branches of the abdominal aorta, to offer organizational technologies for the provision of medical care to patients with gastrointestinal bleeding associated with pseudoaneurysms of the visceral arteries.

Methods. Endovascular image-guided treatment was performed in 12 patients with pseudoaneurysms of the branches of the celiac trunk. Mean age 546.6 years, patients were hospitalized urgently due to ongoing or recurrent gastrointestinal bleeding, severe anemia, with blood hemoglobin level of 80 g/l. The diagnosis of pseudoaneurysm of the visceral artery was established by computed tomography-angiography. The sizes of pseudoaneurysms varied from 12 to 54 mm in diameter. Endovascular surgery was performed on the first day of hospitalization. In all cases, the stent-graft was implanted into the gastrointestinal or splenic artery into pseudoaneurysm ostium. The average follow-up period was 352.2 days.

Results. Endovascular surgery was performed 286.3 hours after making a diagnosis, 2 hours after in-hospital admission. The effectiveness and safety of endovascular treatment was 100% and included stopping the ongoing gastrointestinal bleeding and prevention of its recurrence. Hospital stay of patients was 5 days. The effectiveness stent-graft implantation was confirmed by control angiography. There were no hemorrhagic and embolic complications during follow-up.

Conclusion. Endovascular image-guided treatment and prevention of gastrointestinal bleeding in patients with pseudoaneurysms of the branches of the celiac trunk is an effective and safe method; it is necessary to further improve the organization of endovascular care in order to make it more available to the population and to provide effective care in time in case of development of life-threatening diseases and complications.
Surgical techniques of intraocular lens-capsular bag complex stabilization during cataract phacoemulsification in patients with lens subluxation
Authors: Kopaev S Yu , Il´inskaya I A , Burtseva A A
Published: October 2019

Aim. To develop and to assess the efficacy of the method of one-step upper fixation of a single-piece intraocular lens to the iris during cataract phacoemulsification in patients with lens subluxation.

Methods. The study included 32 patients (37 eyes) with complicated cataract grade 23 combined with grade 12 lens subluxation. Both groups underwent cataract phacoemulsification with consequent implantation of a capsular tension ring and a single-piece intraocular lens. Group 1 (21 eyes) underwent intraoperative one-step upper haptic fixation of a single-piece intraocular lens in vertical position. In group 2 (16 eyes) in 13 cases 61.5 months later a single piece intraocular lens was repositioned and both haptics were sutured to the iris.

Results. In both groups no intraoperative complications occured. Visual acuity in group 1 on days 13 after the surgery was 0.770.19 and was stable during the follow-up. Intraocular pressure was 17.20.99 mm Hg. In group 2 the obtained good functional results 0.780.18 declined due to intraocular lens decentration, the intraocular pressure increased by 6.01.25 mm Hg (up to 24.20.65 mm Hg) which required an intraocular lens reposition in 81.3% of cases. According to ultrasound biomicroscopy, in both groups intraocular lens in all cases had intracapsular fixation and was in a central position.

Conclusion. The developed method of a one-step single piece intraocular lens fixation by suturing the upper haptic to the iris during cataract phacoemulsification in patients with lens subluxation is an effective and safe procedure that allows complete rehabilitation of patients with phacodonesis during a one-step surgical intervention.
Peripheral blood erythrocytes morphology in ovarian cancer
Authors: Fedotova A Yu , Gening T P , Abakumova T V , Dolgova D R
Published: October 2019

Aim. To assess the morphology of circulating red blood cells in patients with stage III ovarian cancer.

Methods. The object of the study was the peripheral blood erythrocytes of primary patients with ovarian cancer (n=25) who had stage III according to International Federation of Gynecology and Obstetrics. Patients were examined in the gynecological department of Ulyanovsk Regional Clinical Oncology Center. The control group included 25 somatically healthy women. Morphological studies were performed using light microscopy. The number of red blood cells with an unchanged and altered shape was expressed as a percentage. By the method of atomic force microscopy, the topology and rigidity of red blood cells was studied.

Results. A statistically significant decrease in the number of circulating blood erythrocytes was found in patients with ovarian cancer compared to somatically healthy women. At the same time, the number of discocytes is markedly reduced while the number of morphologically altered forms: echinocytes, stomatocytes, spherocytes and erythrocyte rigidity are increased.

Conclusion. With the appearance of altered forms of red blood cells and increase of the transformation index and erythrocyte rigidity in patients with stage III ovarian cancer, total number of red blood cells decreases in circulating blood compared to somatically healthy women.
Clinical profile and pattern of bacterial isolates from bile aspirates of cholecystectomy patients
Authors: Goel Shewtank , Pandey Pooja Tripathi , Kumar Abhay , Arora Deval Kumar , Kumar Nidhish , Singh Abhishek
Published: October 2019

Background: Antibiotic policy and appropriate antibiotic prophylaxis cannot be designed unless data is available about bacteria colonizing the bile associated with gall bladder disease.  Authors aim was to assess the clinical profile and pattern of bacterial isolates from bile aspirates of cholecystectomy patients seeking care at a tertiary care teaching hospital.Methods: Patients who underwent cholecystectomy for various hepatobiliary ailments during year 2017-18 formed the study population. Bile aspirates were collected during cholecystectomy and sent to the microbiology laboratory. Ultrasonography, computed tomography and MRCP were done to confirm the gall bladder pathology before surgery.Results: Out of total eighty-six patients, bacterial growth was observed in 28 (32.56%) subjects. As per division of bile samples, maximum number of study participants (39.29%) having bactibilia were seen in Group II. Group with second highest number of patients showing bactibilia was Group III with 9 subjects (32.14%). Eight subjects (28.57%) exhibited bacterial growth in bile aspirates in Group I subjects. Three patients (10.71%) showed bile infected with multiple bacteria i.e. polymicrobial infection. The gram-negative preponderance was seen in all the three groups with Escherichia coli being most common in group I and II. Pseudomonas aeruginosa was isolated in majority of the patients in group II and III.Conclusions: It is advised that all patients undergoing cholecystectomy must have their bile aspirated during cholecystectomy and sent for microbiological examination and culture. It will help in choosing appropriate antibiotic to prevent infection.
An unusual cause of edema in a child with congenital heart disease post Fontan procedure
Authors: Wade Minal , Shettiwar Shweta , Shah Ankita
Published: October 2019

Protein Losing Enteropathy Post Fontan procedure. Protein Losing Enteropathy (PLE) is an uncommon cause of edema in children with congenital heart disease. Protein-Losing Enteropathy may be defined as excessive loss of proteins across the intestinal mucosa and is due to either a primary gastrointestinal abnormality or secondary to cardiac disease. Protein-losing enteropathy (PLE) is a rare complication of the Fontan palliation for functional single-ventricle. Although PLE occurs in about 3.5% of patients post-Fontan, it confers marked morbidity and high mortality within 5 years of diagnosis. The pathogenesis of Fontan-related PLE is not completely understood, and it is unclear why it develops in some patients post-Fontan and not others. We describe a child with Double Inlet Right Ventricle who had undergone Fontan procedure, and presented to us with generalised oedema. The child had hypoproteinaemia, the common causes for which were ruled out and was diagnosed as Protein Losing Enteropathy (PLE) related to his surgical intervention. Though, not frequently encountered it should be kept in mind as one of the causes of anasarca.
Comparative study of cord blood lipid profile in preterm and post term neonates
Authors: Pradeep Pooja , T. Arunkumar , S. Sundari
Published: October 2019

Background: The fetal-origin hypothesis and fetal programming emphasize the profound and sustained impact of factors related to fetal health on the development of chronic disease in adulthood. Several studies suggested that low birth weight and preterm birth linked to abnormalities in cord lipid profile and higher prevalence of atherosclerotic cardiovascular disease. Authors objectives was to estimate and compare cord lipid profile in term, pre-term, and post-term neonates.Methods: In the study group, there were 200 healthy Polish newborns. Newborn characteristics included sex, gestational age at birth, Apgar score, and anthropometric data (weight and length at birth, neonatal ponderal index, head, chest and abdominal circumferences, placental weight, and placental-fetal weight ratio). Cord blood samples were collected for total cholesterol (TC), high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides (TG). Information regarding selected maternal factors was collected. Neonates were classified into preterm (<37 weeks) and term (≥37 weeks) based on new Ballard scoring.Results: The preterm had higher Total cholesterol compared to Term and post term and it was Statistically Significant with a p value of < 0.001. The preterm had higher Triglycerides compared to term and post term and it was statistically significant with a p value of <0.01. The preterm had higher HDL compared to Term and post term and it was statistically significant with a p value of <0.001. The preterm had higher LDL compared to Term and post term it was statistically significant with a p value of <0.001. The preterm had higher VLDL compared to Term and post term and it was statistically significant with a p value of <0.01.Conclusions: Abnormal intrauterine milieu created by maternal changes during gestation may bear a profound impact on lipid metabolism in neonates, which may account for their differences in lipid profile and anthropometry at birth.
O CONTROLE DE CONVENCIONALIDADE DIFUSO DE OFÍCIO E A VEDAÇÃO DAS DECISÕES SURPRESA.
Authors: Lins Rocha Matheus , Vianna Alves Ferreira Olavo Augusto , Vidotte Blanco Tarrega Maria Cristina
Published: October 2019

O controle de convencionalidade é um importante mecanismo utilizado com a finalidade de promover a adequação do ordenamento jurídico brasileiro infraconstitucional aos tratados internacionais de direitos humanos. Ainda pouco utilizado pelos juristas, o controle de convencionalidade em sua modalidade difusa é objeto de estudo no âmbito do processo civil brasileiro. O objetivo deste trabalho é a análise da realização do referido controle diante dos princípios do devido processo legal, do contraditório e da ampla defesa, bem como no que tange às regras e demais princípios elencados no Código de Processo Civil de 2015, dentre elas, sobretudo, a que prevê a vedação das “decisões surpresa”  no âmbito processual, elencada no artigo 10 do referido diploma. O método empregado será o dedutivo,  a técnica metodológica será a pesquisa teórica, partindo-se da análise das pesquisas bibliográficas, da legislação e da jurisprudência, para a aplicação das proposições e conclusões no caso concreto. Será possível verificar, como resultado, de que forma deve ser realizado o controle de convencionalidade difuso, respeitando-se as normativas processuais do Estado Democrático de Direito.
Introduction: Shakespeare and/in Europe: Connecting Voices
Authors: Fayard Nicole
Published: October 2019

Recent Shakespearean productions, just like current European crises, have highlighted the exclusionary nature of European identity. In defining the scope of this special issue, the aim of this introduction is to shift the study of Shakespeare in/and Europe away from the ideological field of “unity within diversity” and its attendant politics of negotiation and mediation. Instead, it investigates whether re-situating Shakespearean analysis within regimes of exclusionary politics and group conflict attitudes helps to generate dynamic cultural and social understandings. To what effect is Shakespeare’s work invoked in relation with the tensions inherent in European societies? Can such invocations encourage reflections on Europe as a social, political and/or cultural entity? Is it possible to conceptualize Shakespearean drama as offering an effective instrument that connects―or not―the voices of the people of Europe?
Cross-Cultural Casting in Britain: The Path to Inclusion, 1972-2012
Authors: Rogers Jami
Published: October 2019

This essay uses three productions to chart the progress of the integration of performers of African and Afro-Caribbean descent in professional British Shakespearean theatre. It argues that the three productions―from 1972, 1988 and 2012―each use cross-cultural casting in ways that illuminate the phases of inclusion for British performers of colour. Peter Coe’s 1972 The Black Macbeth was staged at a time when an implicit colour bar in Shakespeare was in place, but black performers were included in the production in ways that reinforced dominant racial stereotypes. Temba’s 1988 Romeo and Juliet used its Cuban setting to challenge stereotypes by presenting black actors in an environment that was meant to show them as “real human beings”. The RSC’s 2012 Julius Caesar was a black British staging of Shakespeare that allowed black actors to use their cultural heritages to claim Shakespeare, signalling the performers’ greater inclusion into British Shakespearean theatre.
King John in the “Vormärz”: Worrying Politics and Pathos
Authors: Gillett Robert
Published: October 2019

This article picks up on a tendency of recent criticism to look to Shakespeare for insights into contemporary politics, and extends it backwards to the period of German history known as the “Vormärz”―the period between 1815 and 1848. It establishes parallels between that period and the current debates about Brexit, and shows how equivalent issues are reflected in the accounts of King John given by three leading German critics of the “Vormärz” period―which also successively demonstrate the deleterious rise of German nationalism. These issues include: the weaknesses, mistakes and crimes of the powerful, and their effect both on the nation directly afflicted with them, and on others; the issue of national sovereignty and its relationship to the fellowship of nations; the struggle against arguably alien ways of thinking; the dividing line between necessary compromise and rank betrayal; the dilemma of choice; and the poisoned chalice of democratic freedom. And the parallels they establish between Shakespeare, the “Vormärz” and us are as instructive as they are unsettling.
Paciente con lesión medular y trastorno disocial de la personalidad
Authors: Neciosup-Tomé Verónica D. , Reátegui-Vargas Pedro Enrique
Published: October 2019

La lesión medular es una discapacidad mayor, severa y devastadora que altera toda la estructura de personalidad del que la padece, con mayor impacto si se instala en otros cuadros clínicos de base. En este reporte, se presenta el caso de un paciente hospitalizado, con lesión medular traumática y trastorno disocial de la personalidad. Se evalúa el nivel intelectual y patrones clínicos de personalidad, a fin de contribuir a una mejor comprensión y manejo en el proceso de rehabilitación integral de estos pacientes.
A novel rat model of foreign body osteomyelitis for evaluation of antimicrobial efficacy
Authors: L. Brinkman Cassandra , M. Schmidt-Malan Suzannah , J. Karau Melissa , Patel Robin
Published: October 2019

The most common organism-type causing orthopedic foreign body infection is the staphylococci, of which Staphylococcus aureus and Staphylococcus epidermidis are especially common. These organisms form biofilms on orthopedic foreign body surfaces, rendering such infections challenging and time consuming to treat. Our group evaluates novel therapeutics for orthopedic foreign body infection in animal models. A current limitation of most animal models is that that they only allow for the removal of one sample per animal, at the time of sacrifice. Herein, we describe a novel rat model of foreign body osteomyelitis that allows removal of foreign bodies at different time points, from the same infected animal. We demonstrate that this model can be used for both S. aureus and S. epidermidis orthopedic foreign body infection, with 3.56, 3.60 and 5.51 log10 cfu/cm2 S. aureus recovered at four, five and six weeks, respectively, after infection, and 2.08, 2.17 and 2.62 log10 cfu/cm2 S. epidermidis recovered at four, five and six weeks, respectively, after infection. We evaluated the model with S. aureus infection treated with rifampin 25 mg/kg twice daily for 21 days. Using quantitative cultures, we were no longer able to detect bacteria as of the 14th day of treatment with bacteria becoming detectable again 7 days following the discontinuation of rifampin a period. This novel model allows monitoring of evolution of infection at the infection site in the same animal.
Isolation and Characterization of metabolites from Clathria procera Ridley extract and Evaluation of its antidiabetic ef-fects in Streptozotocin-induced diabetic rats
Authors: Tatipamula Vinay Bharadwaj , Polimati Haritha , Rao GSN Koteswara , Ketha Alekhya , Yejella Rajendra Prasad
Published: October 2019

Diabetes mellitus is a lethal metabolic disorder in humankind, which induce chronic complications. The present study investigated the effects of ethyl acetate extract from C. procera (EAE) and its isolates on antioxidant and in vitro antidiabetic activities, along with effects of EAE on plasma blood glucose concentrations in STZ-diabetic rats. For the first time, two known metabolites- N-((2S,3R,E)-1,3-dihydroxyoctadec-4-en-2-yl)stearamide (1) and N-((2S,3R,4E,8E)-1,3-dihydroxyoctadeca-4,8-dien-2-yl)palmitamide (2) are reported from EAE. 1, 2 and EAE depicted significant DPPH, superoxide free radicals, α-glucosidase and α-amylase inhibitory profile, indeed, 1 and 2 showed mild inhibitory profile against aldose reductase. In addition, the EAE (200 mg/kg b.w) revealed significant reduction in plasma glucose, body weight, total cholesterol, total glycerides and LDL levels in STZ-induced diabetic rats. The HDL levels were markedly augmented in EAE treated diabetic rats, when compared with control group. EAE abolished the increased lipid peroxidation in pancreas, liver and kidneys. The histopathological examination of pancreas of EAE protected the Langerhans islets with the number of islet cells were found statistically significant, when compared to diabetic control pancreas. Our data suggest that the C. procera has a potentiality to act against diabetes (both, in vitro and in vivo models) by inhibiting particularly digestive enzymes namely α-glucosidase and α-amylase, however further studies are required for proper establishment of mechanism of action and validating clinical effects.
Railway Ballast Monitoring by GPR: A Test Site Investigation
Authors: Bianchini Ciampoli Luca , Calvi َAlessandro , D'Amico Fabrizio
Published: October 2019

Effective maintenance of railways requires a comprehensive assessment of the actual condition of the construction materials involved. In this regard, Ground-Penetrating Radar (GPR) stands as a viable alternative to the invasive and time-consuming traditional techniques for the inspection of these infrastructures. This work reports the experimental activities carried out on a test-site area within a railway depot in Rome, Italy. Specifically, a 30 m-long railway section was divided into 10 sub-sections reproducing different various physical and structural conditions of the track-bed. In more detail, combinations of varying scenarios of fragmentation and fouling of the ballast were reproduced. The set-up was then investigated using different multi-frequency GPR horn antenna systems. The effects of the different physical conditions of ballast on the electromagnetic response of the material were analysed for each scenario using time- and frequency-domain signal processing techniques. Parallel to this, modelling was provided to estimate fouling content. Interpretation of results has proven the viability of the GPR method in detecting signs of decay at the network level, thereby proving this technique to be worthy for implementation in asset management systems.
In Vitro Benznidazole and Nifurtimox Susceptibility Profile of Trypanosoma cruzi Strains Belonging to Discrete Typing Units TcI, TcII and TcV
Authors: Revollo Suzana , Oury Bruno , Vela Andrea , Tibayrenc Michel , Sereno Denis
Published: October 2019

We ascertain the in vitro Benznidazole (BZN) and Nifurtimox (NFX) susceptibility pattern of epimastigotes, trypomastigotes, and amastigotes of 21 T. cruzi strains, from patients, reservoir and triatomine bugs of various geographic origin. Using this panel of isolates, we compute the Epidemiological cut off value (COwt). Then, the frequency of the susceptible phenotype (Wild type) towards BZN and nifurtimox (NFX) within this set of strains belonging to 3 discrete typing units (DTUs), TcI, TcII, and TcV was deduced. We have observed that the susceptibility status of individual T. cruzi isolates toward BZN and NFX is related to the genetic background and to underlying factors probably related to the individual life trait history of each strain. Analyzing drug susceptibility in this conceptual framework would offers the possibility to evidence a link between isolates expressing a low susceptibility level (not wild-type) as define by the COwt value and none-curative treatment. It will also permit to tract drug-resistant parasites in T. cruzi population.
Pelatihan Desain Grafis dan Multimedia di Sekolah Menengah Kejuruhan Persatuan Guru Republik Indonesia Banyuputih Situbondo
Authors: Budiarto Sony Panca
Published: October 2019

Dalam era milenial dan digital saat ini, dunia desain mengalami perkembangan yang sangat pesat. Dalam hal ini, khususnya generasi muda atau siswa yang masih sekolah perlu dibekali ilmu tentang desain grafis dan multimedia sebagai bekal keterampilan apabila sudah lulus sekolah untuk masuk ke dunia bisnis dalam bentuk desain di luar sana. Kegiatan pelatihan desain Grafis dan multimedia ini difokuskan pada pelatihan desain produk menggunakan Corel Draw X7 dan multimedia fotografi. Dengan mempelajari desain grafis dan multimedia diharapkan para siswa kelas XII SMK PGRI Banyuputih-Situbondo dapat terbentuk skill setelah lulus sekolah untuk berkompetisi di dunia luar agar menjadi sukses dan kompeten, meningkatkan kreativitas dan kualitas karya sehingga berguna bagi mereka dan masyarakat.
ADOÇÃO ANIMAL IFC: INCENTIVANDO A ADOÇÃO DE ANIMAIS ABANDONADOS
Authors: Evangelista Alberto Gonçalves , Santos Anna Carolina Rodrigues , Thomsen Isabelle Cristine , Pacheco Gabriel da Silva , Bortoli Karine Nickel , Rybandt Raquel , Marson Erica Perez
Published: October 2019

O projeto “Adoção Animal IFC” nasceu da iniciativa de acadêmicos do curso de Medicina Veterinária do Instituto Federal Catarinense Campus Araquari. Empregando as mídias digitais, por meio das fan pages “Adoção Animal-IFC”, presentes nas redes sociais Facebook® e Blogger®, além de ações físicas, objetivou promover a adoção de animais que foram abandonados estando provisoriamente em abrigos especializados ou lares temporários. Além do estímulo à adoção, com ênfase aos benefícios mútuos, os recursos metodológicos escolhidos visaram a conscientização das pessoas para a guarda responsável e consequências do abandono. Auxiliando uma Organização Não-Governamental, o Abrigo Animal em Joinville/SC, o projeto, além do veículo digital, inseriu-se no meio físico, promovendo a realização de feiras de adoção e de ações de conscientização. De um total de 83 animais postados nas fan pages, 68 foram adotados, demonstrando que as mídias sociais representam uma importante ferramenta no estímulo às adoções, porém não exime as ações físicas de divulgação. Dados obtidos por meio de um questionário aplicado durante uma ação física revelam que 70% dos entrevistados não conheciam o Abrigo Animal e mais da metade não adotaria um animal por meio das mídias digitais. O projeto Adoção Animal IFC cumpriu um importante papel, inserindo os acadêmicos no exercício da cidadania em prol da comunidade e se diferenciando pela escolha de recursos inovadores e criativos para o estudo do abandono de animais. Novas abordagens são requeridas, uma vez que ainda estamos longe de uma solução efetiva que responsabilize a sociedade e elimine a população de animais nas ruas.

Palavras-Chave: Abandono animal; Guarda responsável; Mídias digitais.
Numerical Simulation of Water Shut-Off for Heterogeneous Composite Oil Reservoirs
Authors: Suleimanov Baghir A. , Feyzullayev Khasay A.
Published: October 2019

The article proposes a mathematical model of water shut-off in a homogeneous and heterogeneous composite horizontal reservoir during the process of two-phase and three-component filtration of fluids with the consideration of capillary phenomena, residual resistance factor, and depth of the water shut-off agent penetration. According to the numerical calculations the residual resistance factor subsequent to water shut-off significantly influences efficiency of the process; moreover, at any stage of field development, significant oil recovery factor increase can be achieved by the residual resistance factor regulation.The depth of the water shut-off agent penetration and the time for its flushing-out are notably depend on the production zone permeability. The proposed model allowstochoosethe best timingfor water shut-off stimulation.
Tumor hypoxia impairs NK cell cytotoxicity through SHP-1-mediated attenuation of STAT3 and ERK signaling pathways
Authors: Wang Yanmeng , Teng Rui , Lv Nan , Williamson Ramone A. , Lei Lei , Fan Rong , Chen Ping , Lei Li , Zhang Yuchen , Wang Baiyan , Peng Yue , Fu Jiaqi , Liu Xuna , He Aili , O’Dwyer Michael , Hu Jinsong
Published: October 2019

Natural killer (NK) cells are innate immune effectors with potent anti-tumor activity. Nonetheless, tumor cells have the ability to create an immunosuppressive microenvironment, thereby escaping from immune surveillance. Although accumulating evidence indicates that microenvironmental hypoxia plays an important role in favoring tumor development and immune evasion, it is still unclear how hypoxia directly impairs NK cell anti-tumor activity. In this study, we confirmed that hypoxic NK cells show significantly lower cytotoxicity against tumor cells. Consistent with this, we also found that the reduction in NK cell cytotoxicity resulting from hypoxia is related to the lower expression of granzyme B, IFN-γ, degranulation marker CD107a, as well as killer activation receptors including NKp30, NKp46, and NKG2D on NK cells. More importantly, we further demonstrated that a reduction in the phosphorylation levels of ERK and STAT3 secondary to hypoxia are tightly associated with the attenuated NK cell cytotoxicity. Focusing on the mechanism responsible for reducing phosphorylation levels of ERK and STAT3, we revealed that the activation of protein tyrosine phosphatase SHP-1 (src homology region 2 domain-containing phosphatase-1) following hypoxia may play an essential role in this process. When knocking down SHP-1 or blocking its activity using a specific inhibitor TPI-1, we were able to partially restore NK cell cytotoxicity under hypoxia. Taken together, we demonstrated that hypoxia can impair NK cell cytotoxicity by decreasing the phosphorylation levels of ERK and STAT3 in a SHP-1 dependent manner. Therefore, targeting SHP-1 could provide an approach to enhance NK cell-based tumor immunotherapy.
Helicobacter pylori infection and increased diabetes prevalence were the risks of colorectal adenoma: a systematic review and meta-analysis
Authors: Wang Horng-Yuan , Lin Ying-Chun , Chen Chieh-Chang , Chen Ming-Jen , Wu Ming-Shiang , Liu Chun-Jen , Huang Chun-Ta , Yang Horng‐Woei , Shih Shou-Chuan , Yu Lo-Yip , Kuo Yang-Che , Hu Kuang-Chun
Published: October 2019

Background

Helicobacter pylori (H. Pylori) infection and hyperglycemia may be associated with an increased risk of colorectal neoplasm. However these two factors affect colorectal neoplasm remain controversial. We aimed to carry out a meta-analysis to evaluate the study population diabetes prevalence rate and H. pylori infection rate with colorectal adenoma risk.

Methods

We conducted a systemic research through English databases for medical reports. We also recorded the diabetes prevalence and H. pylori infection prevalence in each study. We classified these studies into 4 subgroups as their background population diabetes prevalence < 6%(Group 1); between 6 to 8%(Group 2); between 8 to 10 %(Group 3) and more than 10%(Group 4). The random effects model had used to calculate pooled prevalence estimates with 95% confidence interval [CI].

Results

Twenty seven studies were finally eligible for meta-analysis. The random-effects model of meta-analysis was chosen, showing pooled odds ratio (OR) equal to 1.51 (95 % CI 1.39–1.63). The subgroup meta-analyses showed in Group 1 the H. pylori infection associated colorectal adenoma risk OR was 1.24 (95 % CI 0.86–1.78). As diabetes rate exceed 6%, the H. pylori infection became more significant increased risk of colorectal adenoma (Group 2: OR 2.16 (95 % CI 1.61–2.91); Group 3: OR 1.40 (95 % CI 1.24–1.57); Group 4: OR 1.52 (95 % CI 1.46–1.57)).

Conclusions

The results of this meta-analysis showed DM prevalence would affect the risk factor of colorectal adenoma with H. pylori infection.
Magnitude and Associated Factors of Delayed Immunization Among Children Aged 11 -23 Months in Edagahamus town, Tigray, Ethiopia, 2018.
Authors: Hagos Merhawit Gebremeskel , Gebremeskel Teferi Gebru , Kassahun Selam Shushay , Gebrezgi Birhane Hailu , Woldegebriel Manay Kifle
Published: October 2019

Background: Delay in receiving immunization is a major public health problem that has been associated with vaccine-preventable disease epidemics. In Ethiopia, many children have not received the benefits of age-appropriate immunization; thus more than 90% of child deaths are largely due to preventable communicable diseases. Therefore, the aim of this study to assess the magnitude and factors associated with delayed immunization among 12 -23 months old children’s in Edagahamus Town, Tigray, Ethiopia, and 2018 G.C.
Methods: A community-based Cross-Sectional study was carried out on July1-30, 2018. A simple random sampling method was used to select study participants. Information was collected using a structured, pre-tested questionnaire. Vaccination dates were obtained from children’s immunization cards and timeliness assessed based on the recommended age ranges. Data were entered and analyzed using SPSS version 20.0. Variable with P-value < 0.2 in bivariate was exported to multivariate. The strength of association was identified using the odds ratio with a 95 % confidence interval (CI) and the P-value of <0.05 in multivariate was taken statistically significant.
Results: In this study, the overall magnitude of delayed immunization was 29.5% (95%CI 26.7-45). Private firm work of mothers (AOR=0.205 95% CI 0.068-0.617) and Mothers who attend tertiary education (AOR 0.169, 95% CI 0.032-0.882) and secondary education (AOR 0.269, 95% CI 0.114-0.636) had the protective effect of delayed immunization. But the sickness of the child (AOR= 11.8, 95% CI 6.16-22.65) was a risk for delayed immunization.
Conclusions: From the study, it is concluded that the magnitude of delayed immunization for children aged 12-23 months is high (29.5%) in Edagahamus. Delayed immunizations of children were predicted by the Mother's occupation, education, and the mother considered the child was too ill to undertake vaccination when it was due.
Keywords: Child immunization, Delay to be immunized, Vaccine-preventable diseases
Integrated bioinformatics analysis reveals ASPM and CENPF with prognostic value in lung cancer
Authors: li jinghang , Zhang Jing , Huang Lin , Zhao Sheng
Published: October 2019

Lung cancer (LC) is the most frequent type of cancer in the world. But the mechanism of LC is still largely unknown. In this study, we analyzed three lung cancer gene expression microarrays of different pathologic types to explore the potential candidate genes in LC by Integrated bioinformatical methods. 459 overlapped differentially expressed genes (DEGs) were explored in three GEO gene expression profiles of different pathologic types of lung cancer and function annotation of DEGs were performed. The main biological process of DEGs was regulation of vasculature development and angiogenesis. The most significant molecular function of DEGs was TGF-β receptor activity. The most significant Reactome pathway of DEGs was cell cycle and extracellular matrix organization pathway. The PPI network of the DEGs was constructed and 23 candidate hub genes were identified in the network . Kaplan-Meier survival analysis show 21 genes were associated with the prognosis of LC. The genetic alterations analysis of these genes by using cBioPortal shown ASPM has the highest genetic alteration rate of 9% in main pathological types of 3191 LC patients , CENPF has the second highest alteration rate of 6% in LC patients. ASPM and CENPF also identified have a significant co-occurrence relationship in LC, and the GO analysis shown they both participate in the regulation of cell cycle. In the TF -miRNA-gene network of 21 genes shown CENPF have the most significant value in the network and the most relevant TF are NFYA, E2F1 and MYC.In conclusion, this study explored several key genes about LC and analyzed potential TF of those genes, provides possible therapeutic targets and biomarker for further clinical application.
Size of bone flap in decompressive craniectomy: an analysis of complications and prognosis in traumatic brain injury
Authors: Xu Min , Luo Yu , Yi Pan , Wang Cunzu
Published: October 2019

Abstract

Objective: To investigate association of size of bone flap with common complications and prognosis in traumatic brain injury.

Methods: A retrospective analysis was performed in 108 TBI patients of Northern Jiangsu People's Hospital from January 2018 to March 2019. Patients’ gender, age, Glasgow Coma Scale at admisson, pupils reactivity to the light, size of bone flap, types of craniocerebral injuries and injury locations were recorded. Prognostic indicators including changes in hematoma volume and neurological status were extracted. Statistical methods were conducted to evaluate drug efficacy. Prognostic indicators including Glasgow Outcome Scale scores at discharge and GOS scores of 6 months after operation were extracted to evaluate surgical effcacy.

Results : Postoperative complications such as encephalocele and subdural effusion were significantly associated with size of bone flap ( P <0.05). The incidence of encephalocele and SE increased with bone flap size in bone flap groups. Age, GCS at admisson, pupils reactivity to the light, and size of bone flap were shown significantly differences between prognosis groups ( P <0.05). By binary logistic regression, Age, pupils reactivity to the light, and the size of bone flap showed statistical significance ( P <0.05).

Conclusion: Size of bone flap in decompressive craniectomy is a dependent factor to prognosis. Avoiding oversize craniectomy may bring less complications and positive prognosis.
Identification of catechol dioxygenases of acinetobacter species, with improved ability to degrade crude oil
Authors: AL-Kadmy Israa M.S. , Suhail Ahmed , Abid Suhad Abbas , Aziz Sarah Naji , Abed Al-Maamoon H. , Al-sallami Karrar Jasim
Published: October 2019

Background: Various microbes involved in alkanes degradation or reducing organics oil products have been identified among. The goal of this work was to screen the soil bacteria with potential ability to degrade alkanes and characterized using a combination of genetic and physiological methods.Methods: The microbial species of soil sample was isolated and the loss of hydrocarbon was calculated periodically by gravimetric analysis. Isolated bacterial strain with potential ability to degrade the engine oil in Baghdad city was further tested for hydrocarbon-degrading abilities using 2, 6-DCPIP. Colonies of bacteria were counted using serial dilution methods of the soil sample. One of the highly bioactive degrading strains ISN53 was selected and a different fraction of crude extract were analyzed for their hydrocarbon degrading activity. The purified active fraction characterised in LC/MS and SDS PAGE. Presence of chlorocatechol dioxygenases was checked by PCR and expression was analyzed in RT PCR. The envelope of ISn21 isolate was checked for any changes under different conditions using microbial adhesion to the hydrocarbon test (MATH). Results: Serratia marcesens (Sm53) and Acinetobacter venetianus (ISn21) were isolated and ISn21 showed maximum growth on the third day and up to 72% degradation on the 7th day of incubation. LC-MS/MS spectrometry analysis identified the bioactive enzyme catechol dioxygenases in crude extract. The purified catechol dioxygenases enzyme had 35 kDa weight which showed the maximum activity between 48 to 72 hour of incubation. The expression of its gene was 2 fold more than control the maximum expression was observed at 60 to 72 hours of incubation. ISn21 was extremely hydrophobic both in MMV and in LB medium.Conclusion: Using a naturally available resources would be better with efficiency at degrading diesel. Use of like microorganisms during bioremediation operation might supply worthy advances in this important biotechnological/ biological domain.
An observational study of the effects of telmisartan on insulin resistance in hypertensive patients with chronic kidney disease undergoing hemodialysis
Authors: suprapti budi , Dharma Bayu , Drik Mahadri , Izzah Zamrottul , Nilamsari Wenny , Alderman Chris
Published: October 2019

Background In the clinical setting, the activity of telmisartan in decreasing insulin resistance has been proven superior to other antihypertensive drugs in hypertensive patients. However, there has been no published study in determining the effect of telmisartan on insulin resistance in hypertensive chronic kidney disease patients undergoing hemodialysis.Objective To analyze the effect of telmisartan on insulin resistance in hypertensive patients undergoing hemodialysis.Method It was a prospective observational cohort study in 16 chronic kidney disease patients undergoing regular hemodialysis and using telmisartan who met the inclusion criteria.Results Sixteen patients received telmisartan, 12 were male patients and four were female. The mean age was 45 ± 8 years and the mean body mass index was 22.85 ± 1.99. Hypertensive chronic kidney disease was the highest etiology (56%) for hemodialysis. Mean percentage of fasting plasma insulin and homeostatic model assessment of insulin resistance concentratons decreased significantly by 22.6% (P<0.05) and 22.9% (P<0.05) respectively after 3-month administration. On the other hand, the mean percentage of fasting plasma glucose concentrations declined by 2.9% (P=0.187, Zcount<1.96) after 3-month of treatment.Conclusion Administration of telmisartan for three months decreases insulin resistance significantly in hypertensive patients undergoing hemodialysis.
Young adult renal service: Does having a dedicated young adult service make difference to patient outcomes?
Authors: Williamson Samantha , Myton Jemma , Evison Felicity , Kerecuk Larissa , Lipkin Graham , Pankhurst Tanya
Published: October 2019

Background Young adults with chronic renal disease face the rigours of adolescence alongside the responsibility of safeguarding their own health. They have poorer renal transplant outcomes than other age groups presumed due to non-adherence with medication and clinic attendance. We had set up a Young Adult Service and aimed to understand whether this had reduced distress in young adults and impacted positively on renal transplant survival. Methods Transplant patients aged 16-24 years who had transferred to adult renal services between 2000 and 2006, prior to commencement of a dedicated young adult service, were studied as historical controls. This patient group was compared to the current young adult transplant cohort. Missed appointments, serial renal function and transplant survival was collected. The current young adult cohort were assessed for markers of ‘distress’ and this was correlated with clinic attendance and transplant outcomes. Young adults were surveyed for their opinion of the service. Results Five year transplant survival increased from 65% to 98% concurrent with Young Adult Service commencement. 60% of patients reported distress and this correlated with missed clinic appointments. By offering more appointments to this group and increasing support, neither distress nor missed appointments impacted transplant outcomes despite the high risk in this patient cohort. The service was well received by young adults. Conclusion A dedicated Young Adult Renal Service may protect from poor renal transplant outcomes by providing increased holistic support.
Self-medication with antibiotics of parents of different nationalities in China: analysis of irrational use of antibiotics from demand side
Authors: Zhou Zhongliang , Zhao Dantong , Zhang Huarui , Shen Chi , Zhu Liang , Zhao Yaxin , Cao Dan , Ren Yangling , Si Yafei , Ma Siwei , Fang Yu
Published: October 2019

Background: There is an increasing trend on practicing self-medication with antibiotics in both developed and developing countries. Bacterial resistance caused by antibiotic use has become an important public health concern. This study contributes to explore the effect of different demanders but the same supplier on parental self-medication with antibiotics for children. It intends to analyze the difference in self-medication with antibiotics of parents of different nationalities for children under the same health service supplier in the context of Chinese policies, and compare their differences in knowledge, attitudes and behaviors about antibiotics.
Methods: A cross sectional study was designed to investigate all 310 parents of different nationalities (Chinese, other Asian and Occidental) whose children were studying in an International Department of an International School in Xi'an, Shaanxi, China on September 2018. Pearson Chi-square test and Binary Logistic Regressions were used to analyze the data.
Results: The results showed the rate of parental self-medication with antibiotics for children was 13.85%, where parents of three nationalities were respectively 20.10%, 5.00% and 2.67% ( P <0.001). Chinese parents were respectively 8.221 ( P <0.01) and 6.086 ( P <0.05) times more likely to have self-medication with antibiotics for children compared to Occidental parents in two regression models controlling different confounders. Occidental parents had higher correct rate of knowledge, attitudes and behaviors about antibiotics than Chinese parents and followed by other Asian parents in total ( P <0.001).
Conclusions: The study found that parents' nationality was an influencing factor on parental self-medication with antibiotics for children that Chinese parents were easier to self-medicate for children than Occidental parents. Occidental parents performed better than Chinese and other Asian parents in knowledge, attitudes and behaviors about antibiotics. It is recommended for health administration not only to strengthen the supervision and regulation to health service supplier, but also health education to parents on knowledge, attitudes and behaviors about antibiotics.
Key words: China; Self-medication with antibiotics; Parents of different nationalities; Knowledge; Attitudes; Behaviors
Social and Family Factors as Determinants of Exercise Habits in Japanese Elementary School Children: The Super Shokuiku School Project
Authors: Sawa Satomi , Sekine Michikazu , Yamada Masaki , Fukazawa Yugo , Hiraku Yusuke
Published: October 2019

Background

Many studies have already reported on the relationship between exercise habits and health among schoolchildren. However, few have examined social and/or family factors as determinants of exercise habits. This study investigated factors related to both dislike and lack of physical activity among schoolchildren.

Methods

This study’s participants included 1,984 school children (1,001 boys and 983 girls) aged between 6 and 13 from the Super Shokuiku School Project in January 2016. A survey was conducted to assess sex, grade level, physical activity, lifestyle, overall health, enrichment of school life, social background, and parental lifestyles. Both the dislike and lack of physical activity were defined as poor exercise habits; correlates were analyzed using a logistic regression.

Results

“Lack of close friends” had the strongest links with both dislike (adjusted odds ratio [OR] 5.30; 95% confidence interval [CI], 2.78-10.1) and lack of (adjusted OR 5.40; 95%CI, 2.81-10.4) physical activity. Further, children who engaged in long periods of screen time and lacked parental communication also tended to dislike and lack physical activity. Children with mothers who were unemployed (housewife) and had undesirable lifestyles as well as those with poor health were also more likely to lack physical activity.

Conclusion

Social and family factors (e.g., close friends) may be determinants of exercise habits among schoolchildren independently of their own lifestyle factors. Although a longitudinal study is needed to determine causality, substantial attention should thus be paid to these factors when promoting physical activity.
DEVELOPMENT OF A PERSONALIZED MEAT PRODUCT USING STRUCTURAL-PARAMETRIC MODELING
Authors: Lisitsyn Andrey B. , Chernukha Irina M. , Nikitina Marina A.
Published: October 2019

At present, there is no consistent definition of the term «personalized nutrition». The paper presents existing descriptors in this field of food science: precision nutrition, nutrigenomics, nutrigenetics, individual nutrition and so on. It is noted that cardiovascular diseases occupy the first place among noninfectious diseases associated with malnutrition. Optimal nutrition leads to a reduction in the risk of their occurrence. The methodology of structural-parametric modeling, which allows designing personalized optimal human nutrition based on medical indicators, is presented in terms of minimization of the risk function. The algorithm of a substantiated optimal choice of mass fractions of components (ingredients) of the food recipe composition is given. The main descriptors of a food product with the antisclerotic action for its designing using structural-parametric modeling are shown.