bluuebunny/crossref_metadata_2025 huggingface dataset:
CYTOLOGICAL FINDINGS BEFORE AND AFTER PROBIOTICS (LACTOGYN)
Authors: Perišić Ž. , Vukićević D. , Perišić N. , Janković Ražnatović S. , Tasić L. , Dimitrijević Lesendrić Lj. , Perišić M. , Perišić M.
Published: November 2024

Probiotics help to provde optimum balance in the intestines probiotics species competitive blocks toxics substances and growth of unwanted species in their struggle for space and food. Lactogyn is the first oral probiotics wich protects vaginal flora. The most researced probiotic is the Lactobacillus rhamnosssus. The goal of this study is to exam influence of probiotics to cytological smear test including: reliability for easier detection of atypical cells; false positive and false negative test; faster cytodiagnostic; incidence of invasive diagnostic procedures and incidence of intraepithelial and invasive changes of the lower genital tract. This study involved two groups of patient: the first one included 50 patients who has been taken specific probiotic therapy after taking cytological cervical smear test. The second one included 50 patients who has taken specific probiotic therapy before taking cytological cervical smear test. In the second group we discovered: statistically lover number od invasive diagnostic and therapeutic methods and statistically higher number of patients without invasive methods. It was statistical higher incidence of cytological smears with inflammations and ASCUS (atypical squamous cells undetermined significance) in the second group of patients. Lactogyn treatment with other medicament therapy provides: faster and better cytological diagnostic, decreases the number of cytological tests and invasive diagnostics methods per women, decreases the number of false positive and false negative tests and the percent of unsatisfactory tests and borderline satisfactory tests
DEPRESSION AS RISK FACTOR FOR THE DEVELOPMENT OF THE COGNITIVE ADVERSE EVENTS OF TOPIRAMATE IN THE TERAPY OF EPILEPSY
Authors: Milošević N. , Sokić D. , Ristić A. , Vitošević Z. , Petrović N. , Trajković G. , Mitrović V. , Vukotić M. , Radić I.
Published: November 2024

Patients with epilepsy more often than healthy individual have cognitive disorders, what may be the result of different factors, among which significant place occupy the treatment with antiepileptic drugs. Topiramate is the new antiepileptic drug, which is related with high efficiency in the reduction seazures, and also whit high prevalention of cognitive adverse events. Purpose of our study is to clarify the role of depression in developing cognitive adverse events during therapy with topiramate in patients with refractory epilepsy. In the prospective stady we followed 40 adult patients with refractory epilepsy, which treatement took place on the Institute of neurology Clinical center of Serbia. All patients are neuropsychological tested twice. First time before the start of therapy with topiramate on basic antiepileptic therapy, and next time two months after the achieving of stable dose of 200mg/day. We used neuropsychological tests for evaluation attention, concentration, visual and verbal memory, speech, executive functions, divergent opinion and visual construction abilities. For estimate degree of depression we used Hamilton's scale of depression. Patients with the depressive manifestation had lower scores on cognitive tests in comparition to patients without the depression, before and after introductions topiramate. More the score of depression was larger, the scores of neuropsychological tests have been worse. Depression has bad influence on the cognitive functioning and her presence in the patients with epilepsy increases the risk from development of cognitive adverse events of topiramate.
INCIDENCE OF STRESS-ULCЕR IN SEPTIC PATIENTS
Authors: Janićijević-Hudomal S. , Rašić J. , Mikić D. , Piperski V.
Published: November 2024

Serious metabolic diseases and infections, such as sepsis, may lead to the occurrence of stress ulcers. Unfortunately, in our hospitals, the stress ulcer is often diagnosed as a separate disease, not as the manifestation of the existing stress status of the patient. Therefore, the goal of this pilot study was to establish the incidence of stress ulcers in sepsis patients treated at the Infective Disease Clinic. Patients treated at the Military Medical Academy Infective Disease Clinic during 4 month period, who experienced acute bleeding, verified gastroscopically, were subjected to retrospective analysis. Five out of 344 hospitalized patients had serious hemorrhages. Out of a total of 21 patients diagnosed with bacterial sepsis, acute gastric bleeding was verified gastroscopically in three, or 14.28 percent. To obtain more data, prospective long-term study, wich would include greater number of septic patients, should be conducted.
OCULAR CHANGES OCULAR CHANGES AT SERONEGA SERONEGATIVE ARTHROPATHY
Authors: Mirković M. , Jakšiċ V. , Žorić L. , Vukša D. , Stamenković D. , Bulajić S. , Petković Z.
Published: November 2024

Seronegative arthropathy represents group of rheumatic diseases which affects younger patients, more often male. Ocular findings are numerous such as conjunctivitis, iridocyclitis, and they are a part of extraarticular clinical manifestations. Acute anterior uveitis, as most common ocular manifestation, could be a sole or associated morbidity condition at the forme of systemic diseases.
MASSIVENESS OF A SICKNESS, A PATHOGENIC OF CONTAGIUM AND HENLE-KOCH POSTULATES
Authors: Čukić G.
Published: November 2024

Total happening «en masse» is important to epidemiologist - and so it is «massive manifestation of natural system of the sickness» (PSB). Manifestation "en masse" of the natural system of parotitis N makes quantities of qualities N , N , B b N , N , N etc. a) «Causative connection» (UV) is the reason of sickness appearance. UV has its own causes of appearance, Z neB z and so the hierarchy of cause in the complex happening from subsystem. Nongenotopic or/and entropic causes of appearance of causative bonds (connections) as equilibrium connects and/or separates binary elements of causative bond  (connection). Pathogenic of contagium exists virtually in happening «en masse» in pre pathogenesis, prior to forming «immanent UV». b) Realising conjunction between the subsystems makes appearance of «immanent causative connection». That is a moment from which comes to obligatory demonstration of pathogenic as inner cause of contagium and consequent getting sick. The author concludes that «natural work» is the cause by which UV appears. Natural work is outer cause of massiveness. Just by appearance of "immanent UV" the showing of contagium pathogenic in the subsystem of sickness. The pathogenic of contagium can be proved by artificial experiment and that way the Henle-Koch postulates can be satisfied, It happens that way that input disturbance unable to be shown. Finally, anyway natural happening should pass judgement on authenticity of the theory on natural happening. 
FEET DEFORMITIES AMONG CHILDREN AS A NEGATIVE IMPACT FACTOR ON RUNNING ABILITIES
Authors: Stanković V. , Jovašević Lj. , Toskić D. , Đukuć-Macut N.
Published: November 2024

The aim of this study was to determine the functional state of the feet of 40 boys aged 12 and 6 moths up to 13 and 6 months and by using the criterion variable of the 500 m run, to carry out a comparative analysis of their running speed. The subjects were divided into three groups: group I which numbered 14 boys with normal feet, group II which numbered 14 boys with high arches (pes excavatus) and group III numbering 12 boys with flat feet (pes planus). The diagnosis of the feet conditions was made following the inspection of the Achilles' tendon and the medial edge of the foot, followed by a plantogram. The statistical analysis of the results from the 500 m run was carried out by means of basic statistics, the analysis of variance (ANOVA) and the Ò criterion used to determine the source of the variability while testing the normality of the distribution. The analysis of the obtained results led us to the conclusion that foot deformities represent a negative factor for the ability to perform the 500m run which is one of the requirements in the battery of tests used in elementary schools. The analysis of variance, ANOVA, has indicated that there are significant differences between the boys in terms of their results for the 500 m run (p=.00). The difference between the average running time of the boys with normal feet and the boys with high arches is not statistically significant, while the differences between the average results of the run for the boys with normal and flat feet, as well as between the boys with high arches and flat feet are statistically significant, which led us to the conclusion that flat feet have a greater negative impact on the running ability than high arches. We can assume that boys with feet deformities (especially the ones with flat feet) will probably be less physically active than boys with high arches, which also leads to their significantly weaker running abilities. 
THE INFLUENCE OF THE METABOLIC SYNDROME ON THE ETIOPATHOGENESIS OF BILIARY CALCULOSIS
Authors: Milinić S. , Kostić-Inić B. , Novaković T.
Published: November 2024

The metabolic syndrome is characterized by a group of metabolic risk factors causing type 2 diabetes (DM2) and cardiovascular diseases. At the heart of this pathogenic disorder is insulin resistance. The metabolic syndrome is often accompanied by diseases of the gallbladder (chronic inflammations and calculosis). The goal of our study was to observe the changes made on the gallbladder with patients diagnosed with the metabolic syndrome, specifically the presence of calculosis and cholecystitis. The study involved 130 patients with the metabolic syndrome and 40 healthy subjects, all of which were subjected to abdominal ultrasonography. Gallbladder calculosis was found in 36,92% subjects of the study group and 12,50% subjects of the control group, resulting in a statistically considerable difference (p<0,001). The results of our study indicate a significant presence of biliary calculosis as one of the manifestations of the metabolic syndrome on the biliary system.
NEUROPHYSIOLOGIC CORRELATES OF EPILEPSY IN COMPLEX FEBRILE SEIZURES
Authors: Opačić A. , Ivetić V.
Published: November 2024

Febrile seizures are the most common neurological disorder of early childhood. By expressing the characteristics febrile seizures are divided into simple and complex. Our aim was to determine the elektroencephalography characteristics in children who had febrile seizures, and determine the relation between types of febrile seizures correlates with the appearance of epilepsy in children aged 9-11 years. In the group of children studied, 50% had a complex febrile seizures, 42.2% had simple febrile seizures, and 7.8% children had febrile epileptic status. The analysis of EEG findings observed were statistically significant differences in specific changes in the EEG depending on the type of febrile attack that the child would have. In the group of children with simple febrile attacks 92.1% has a normal EEG, 2.6% had a specific, a 5.3% nonspecific finding. For children with complex febrile attack, 44.4% have a specific, and 13.3% of non-specific changes in EEG. Specific changes in the EEG has 28.6% of children who had febrile epileptic status.
SOCIO-PEDIATRICS ASPECTS OF CILDREN’S ACUTE ORGANOPHOSPHATE POISONING
Authors: Drmončić-Putica J. , Živković J.
Published: November 2024

It is argued that the easy availability and widespread use of highly hazardous organophosphate compounds (OPC) is the most important reason for this high number of poisoning. In this study socio pediatrics aspects of children¢s acute intoxications OPC were investigated.Data collected included age, gender, time, rout of åxposure, place of accident, first aid before admission. Àll were do to accidental event attempted suicide cases. Acute OP poisoning is a the important cause of morbidity and mortality and represent serious condition that needs rapid diagnosis and tretman because. Therapy should be started as early as possible beginning from primary and secondary level so undesirable consequences can be avoided.
AN ASSESSMENT OF INCOMPLETE EXCISION OF SKIN CANCER - IMPACT OF ASSOCIATED FACTORS
Authors: Videnović G. , Bjelogrlić G. , Stojanović-Kamberović V.
Published: November 2024

Skin cancer is the most common form of human cancer. The annual rates of all forms of skin cancer are increasing each year, representing a growing public health problem. The two most common form of skin cancer are basal cell and squamous cell carcinoma, well known as nonmelanoma skin cancer. Treatment of nonmelanoma skin cancer depends on the type and location of the skin cancer as well as the age and general health of the patient. Surgical excision is the most common metod in the treatment of basal and squamous cell carcinoma. One of disadvantages of simple surgical excision is incomplete margin control. The aim of this prospective study was to assess the influence of the size of the tumor and intraoperative surgical margin on the rate of complete excisions of skin cancer. A total of 64 basal cell and squamous cell carcinomas were excised and analyzed. Data pertaining to patient age, sex, lesion size and margin of excision were collected prospectively. After excision, all tumors specimens were histopathology confirmed completeness/ incompleteness of tumor excision. Tumor size ranged from 5mm to 36mm. Surgical margins were used in the range of 5-12mm. Skvamocelularni carcinomas were incompletely removed in 4.2%, and basal cell carcinomas in 10% of cases within the histopathological groups. Basal cell carcinomas: surgical margin of 5 mm radically removed 83.3% (up to 1cm); 8mm margin- 86.7% (1-2cm): and 10mm 100% (over 3cm). Squamous cell carcinomas: 10mm surgical margin removed 100% tumors up to 3cm.
THE MOST COMMON PATHOGENS OF BACTERIEMIA AND THEIR RESISTANCE IN HOSPITALIZED PATIENTS
Authors: Đorđević Z. , Milinić S. , Stolić R. , Đonović N.
Published: November 2024

To show the most common causes of bacteriemia in hospitalized patients, as well as their sensitivity to antimicrobial agents. The research data were extracted from official reports produced by Microbiological Laboratory in Clinical Centre Kragujevac. Isolation and identification of the causes were performed with standard microbiological methodology. Sensitivity to antimicrobial medication was tested using disc diffusion. Interpretation and inhibition zones of antibiogram were done in accordance with guidelines of US Clinical and Laboratory Standards Institute (CLSI). A descriptive epidemiological approach was used in the research. The collected data were processed using the appropriate software application. Amongst the processed samples, a significant presence of Staphylococcus spp. was found (coagulase-negative 35,8% and coagulase positive 11,7%). Over 60% of Staphylococcus aureus isolates were resistant to meticillin. Enterococcus spp, isolated in 11,7% of all isolates, in more than 50% of cases was sensitive to ampicillin, with approximate isolate vancomycin sensitivity of 90%. The isolated Klebsiellà spp strains produced high degrees of Extended-Spectrum â-Lactamases (ESBL) and showed resistance to third-generation cephalosporins, aminoglycosides and ciprofloxacin, with 100% sensitivity to carbapenem. Pseudomonas spp and Acinetobacter spp were less represented (5.8% and 5.4%) but these neither pathogens were exempt to antimicrobial resistance.The research indicated that causes of hospital infections should be continuously monitored. 
ADRENERGIC β2 AGONISTS IN THERAPY OF PATIENTS 2 WITH BRONCHIAL ASTHMA
Authors: Popović D. , Đurić M. , Naumović N. , Ivetić V. , Sečen N. , Lazić Z. , Lazić Z.
Published: November 2024

Bronchial asthma is the syndrome, characterized with chronic inflammation, hyperreactivity and obstruction of the respiratory pathways, accompanied with consequential symptoms and remodeling of the respiratory pathways. Application of inhaled corticosteroids accompanied with appropriate education of patients, significantly improve therapeutic treatment and outcome of the asthma. But, improvement of the lung function and patients subjective state is remarkable better yif inhaled corticosteroids are combined with adrenergic â2 agonists, than if the dose of inhaled corticosteroids is increased. So, according to Global initiative for asthma and clinical results long acting adrenergic â2 agonists in combination with inhaled corticosteroids are most efficient in asthma treatment and establishment and conservation of bronchial asthma control. 
APPLICATION THE PERSONAL COMPUTERS IN RADIOLOGY
Authors: Todorović A.
Published: November 2024

In this paper the role of personal computers (PC) in radiology was emphasised. PC have important role in medial image generation, in digital RTG, ultrasonography, endoscopy, tomography (CT, MR, PET). We emphasised the importance of PC in DICOM (Digital Imaging and Communications in Medicine) and image postprocessing, control and managing of radiology systems and PACS-a (Picture Archiving and Communication System) based on PC for transfer and archiving of medical images.
INFLUENCE OF ARTERIOVENOUS FISTULAE FOR HAEMODIALYSIS ON THE OCCURRENCE HEART FAILURE - CASE REPORT
Authors: Stolić R.
Published: November 2024

It is known that arteriovenous fistula for hemodialysis has an unfavorable impact of dialysis patients but their exact role in the development of heart failure was not clear enough. The paper presents a patient who is on chronic hemodialysis program is nine years, in which there was a clear clinical symptoms and signs of heart weakness, probably aided by a pronounced flow through arteriovenous fistula. Left ventricular hypertrophy due to volume of arteriovenous fistula, is not the only reason for the emergence of global heart failure.
RIGHT VENTRICULAR INFARCTION - A CASE REPORT
Authors: Lazić S. , Čelić D. , Sovtić S. , Marčetić Z. , Šipić M. , Milinić S. , Perić V. , Lazić B.
Published: November 2024

A characteristic hemodynamic pattern has observed in patients with right ventricular infarction, with frequently accompanies inferior left ventricular infarction or rarely occurs in isolated form. The electrocardiogram may provide the first clue that right ventricular involvement is present in the patient with inferior wall myocardial infarction. Most patients with right ventricular infarction have ST- segment elevation in lead V4R (right precordial lead in V4 position). ST segment elevation of 0,1mV or more in anyone or in combination of leads V4R, V5R, and V6R in patients with the clinical picture of acute myocardial infarction (MI) is highly sensitive and specific for the diagnosis of right ventricular MI.
ACTIVITY XANTHINE OXIDOREDUCTASE AND OXIDATIVE STRESS IN PLASMA HYPERTENSIVE AND HEART FAILURE PATIENTS ASSOCIATED WITH AGE-RELATED CATARACT
Authors: Kisić B. , Mirić D. , Stolić A. , Dragojević I. , Žorić L. , Stanić M.
Published: November 2024

Oxidative stress and associated oxidative damage are mediators of vascular injury and inflammation in many cardiovascular diseases, including hypertension, atherosclerosis, ischemic heart disease, diabetes. Xanthine oxidoreductase is one of the enzymes producing free radicals in the cardiovascular system, and it can contribute to the increment of the oxidative stress and, consequently, blood pressure. The xanthine oxidase is a molybdoenzyme capable of catalyzing the oxidation of hypoxanthine and xanthine in the process of purine metabolism. Xanthine oxidase can exist in two interconvertible forms, either as xanthine dehydrogenase or xanthine oxidase. The aim of the paper was investigate the activity xanthine oxidoreductase in the plasma patients with age related cataract, with hypertensive, and with heart failure. Clinical and biochemical researches were carried out in 73 patients with age related cataract, mean age 72±7 years, divided into group with hypertensive (N=35), with heart failure (N=22) and group normotensive and without heart failure (N=16). Plasma xanthine oxidoreductase activity was determined spectrophotometrically by measuring the formation of uric acid from hypoxanthine at 293 nm. The concentration of triglycerides (TG), total cholesterol (TC), LDL-C, HDL-C in plasma were determined. Our findings show a significantly increased activity xanthine oxidoreductase in plasma hypertensive patients (XO 9.18±1.5 U/L) (p< 0.001) and patients with heart failure (XO 10.44±1.53U/L) (p< 0.001), compared with values plasma xanthine oxidoreductase activity in normotensive and patients without heart failure (XOD 6.02±1.4 U/L). Concentrations of plasma TG, TC and LDL-C were elevated in groups with hypertensive and with heart failure, and we to find significant differences with group normotensive and without heart failure values. Elevated activity of plasma xanthine oxidoreductase contribute to the increasåd oxidative stress and may play a role in accelerated atherosclerosis. 
THE EFFECT OF CHANGE OF LIFESTYLE AND THERAPY OF METFORMIN IN NEWLY DIAGNOSED PATIENTS WITH TYPE 2 DIABETES
Authors: Novaković T. , Kostić B. , Sojević Z. , Milinić S. , Krstić N. , Sovtić S. , Marčetić Z. , Jovanović A.
Published: November 2024

Metformin is an anti-hyperglycemic agent used for the treatment of type 2 diabetes mellitus. Biguanides lower blood glucose levels primarily by decreasing the amount of glucose produced by the liver. Metformin also helps to lower blood glucose levels by making muscle tissue more sensitive to insulin so glucose can be absorbe. The purpose of the study was to establish the effect of metformin on insulin secretion in obese patients with newly diagnosed diabetes mellitus type 2. We included 40 patients with Type-2 Diabetes Mellitus, who were treated on Department for Internal Disease in Hospital King Milutin Laplje Selo. Patients included in the study were newly diagnosed with diabetes mellitus type 2, glycemia < 12 mmol/L, and hed the Body Mass Index >30 kg/m2. They were treated with metformin, 1000 mg/day. Insulin sensitivity was determined by HOMA IR, insulin secretion by HOMA, lipid status by spectrophotometry. After six months of treatment blood biochemistry tested again. BMI was also established. Metformin significantly lowered BMI (BMI before therapy 31.02 kg/m2, after treatment 28.7 kg/m2) (both p<0,001 vs baseline) waist circumference mean value 98±0.55 cm-93,12 cm. (p<0,001) During the therapy the glycaemia decreased from 11.7 mmol - 6,78 mmol/l, insulinemia mean value 20.141 mlU/l -13.691, HOMA IR elevated in all patients. Among the cholesterol fractions, most significant results were obtained in LDL cholesterol. Mean LDL cholesterol levels 4.51± 2.02 mmol/L. Mean cholesterol level 6.98±2.31 mmol/L. HDL levels -1.32 mmol/L. Serum triglycerides was (mean) 2.63±1.32mmol/L. After six months therapy Metformin produces beneficial changes in lipid states. Metformin may be the first therapeutic option in the diabetes mellitus type 2 with overweight or obesity. Metformin produces beneficial changes in glycemia control, and moderated in weight, lipids and insulinemia. 
SELF-EVÀLUATED HEALTH CONDITION AND LEADING HEALTH PROBLEMS OF THE REFUGEES FROM THE REFUGE CAMPS IN THE NORTH KOSOVO AND METOHIJA
Authors: Đurić S. , Bašić S. , Mirković M. , Radosavljević B.
Published: November 2024

Evaluation of population health condition is a basic mode of collecting health condition and health needs data of a population. Evaluation of population health condition is a base of contemporary health care and health service as well as health improvement and further health system development. In order to gain information on all (physical, psychological and social) health aspects, one has to go beyond health care system and consider objective health condition indicators gained by routine health statistics along with subjective information for creation an image of health condition, that is to say data collected from citizens themselves. This is significantly important when health condition data are sparse, as this is the case with health marginalized groups such as refugees and displaced persons. Value of data collected in this way is in the fact that they refer to determinants defining health, such as social-economical status, life style, education, employment, quality and availability of health care. The aims of this research is to establish how refugees, housed in refuge camps in the North Kosovo and Metohija, evaluate their health and what are the most common health problems of this population. The research was undertaken as a study of a standard representative sample of the adult refugees housed in the refuge camps in the North Kosovo and Metohija. It involved 109 surveyed people. The questionnaire, used for Health Examination in the Republic of Serbia adapted to local conditions, was utilized as a research instrument. The data were processed by descriptive statistics methods 2 and ÷ test was used in the means of data analyzing. More than a half of the surveyed (55.1%) answered that their health condition was good and very good. There is a great difference in health self-evaluating regarding age, marital status, education, the year when they arrived to current domicile. Less than two thirds (65.2%) of the surveyed in the refuge camps in North Kosovo and Metohija claimed that they suffer from some mentioned chronic illnesses. 
CONNECTION OF TUMOR BUDDING, LYMPHATIC VESSEL INVASION AND LYMPH NODE METASTASIS IN COLORECTAL CARCINOMAS
Authors: Đerković B. , Vančentović-Mijović M. , Vukićević D. , Mitić N.
Published: November 2024

Tumor budding refers to an isolated cell or a cluster of up to five undifferentiated tumor cells, located in the stroma close to the invasion frontline of a carcinoma. It has been observed that tumor budding invariably precedes both an invasion into the lymphatic vessels surrounding a tumor and the development of metastases in lymphatic nodes. The aim of this paper is to determine the link between tumour budding, lymphatic vessel invasion and presence o lymph node metastasis in colorectal carcinomas. The study involved 92 cases of colon and upper rectum cancers removed at the Trebinje General Hospital and the Medical Centre in Kosovska Mitrovica. High-grade tumour budding was diagnosed in 66 (71.7%) cases, and lowgrade tumour budding in 26 (20.3%) cases. Lymphatic invasion was detected in 63 (68.5%) cases (55 (87.3%) of these cancers showed high-grade tumour budding, while on the other hand 8 (12.7%) had low-grade tumour budding). Lymphonodal metastases were found in 45 (48.9%) cases (of which 36 (80.0%) were high-grade and 9 (20.0%) low-grade incidents). Based on the ÷2-test, it may be concluded that the distribution of tumour budding in relation to lymphatic invasion (p<0.001) is statistically very significant, which was not confirmed in the case of metastases developing in lymphatic nodes (p>0.05). In conclusion, tumour budding is highly linked to lymphatic invasion, which it most probably precedes. 
RELIABILITY OF THE DISEASE SEVERITY MEASURES AND THE RELIABILITY OF THE HEALTH RELATED QUALITY OF LIFE MEASURES OF THE PEOPLE WITH PSORIASIS
Authors: Sojević-Timotijević Z. , Majcan P. , Dostanić N. , Perišić S. , Relić M. , Ilić A.
Published: November 2024

The objective of this study that included 34 patients with psoriasis was to assess the reliability of the disease severity measures (i.e. Psoriasis Area and Severity Index - PASI) and the reliability of the health related quality of life measures (i.e. EuroQol EQ-5D Quality of Life Scale - EQ-5D, Dermatology Life Quality Index - DLQI and Psoriasis Disability Index -PDI). High interobserver correlation reliability and good test-retest reliability of PASI scores, as well as good test-retest reliability of EQ-5D, DLQI and PDI scores were achieved. Correlation coefficients between the test and retest scores on DLQI and PDI were higher than those on the dimensions and on EQ-VAS in EQ-5D. Disease severity scores given by PASI and the quality of lify scores given by EQ-5D, DLQI and PDI offered the reliable assessment of both the psoriasis severity and the quality of life of the people with psoriasis.
DISCUS HERNIA AS ENTITY DEGENERATIVE LUMBAR SINDROME
Authors: Dani R. , Popović M.
Published: November 2024

Degenerative diseases are no inflammatory diseases intervertebrales discus, joints and ligaments vertebrae with subsequent changes in the bony spine structures. Degenerative diseases are very common and lumbar syndrome is most of them common. Because large disability that gives not only a medical but also social and economic problem. Starting of these facts here, work is set purpose,to the overall context of the diagnosis,differential diagnosis of degenerative lumbar sindrom. This is a complex problem that requires a great effort, expertise and modern diagnostic procedures in clinical rheumatology, which is outstanding problem in practice. We hove processed 55 patients with chronic low back pain and 20 patients with chronic low back pain and other etiology. With history, clinical examination, laboratory analysis, Rtg recordings,and other additional analysis (EMG,CT,MRI) that dodge tried to make the diagnosis and successful treatment.
OUTCOME OF THE DELIVERIES WITH BREECH PRESENTATION ACCORDING TO THE PERFORMED MANUAL ASSISTANCE
Authors: Jovanović N. , Petronijević M. , Vrzić-Petronijević S. , Opalić J. , Bogdanović Z. , Dotlić J.
Published: November 2024

Introduction: Delivery with foetus in breech presentation carries a dilemma for obstetrician concerning the method of choice which would be the best for the foetus and the mother. Goal: The aim of this study was to analyse the frequency of breech presentation, mode of delivery and the methods of manual assistance concerning the Apgar score of the children at delivery. Method: Study involved all women with a child in breech position who gave birth in the Institute for Gynaecology and Obstetrics of the Clinical Centre of Serbia in Belgrade during the period of six years. Results: Frequency of the breech presentation in the investigated period was 4.5%. In the last three years children in breech presentation are delivered more often by caesarean section (2.7-3.1%) than vaginally (1.6-1.7%). In vaginal deliveries manual assistance by Bracht/Lowset was performed most often- in 70.5%. At the second place is manual assistance by Bracht- in 18, 2%. Feet extraction of the foetus is performed in 4.4% of deliveries. The frequency of Smeli-Veit assistance is 6.7%, while the Forceps was used in 0.3% of cases. High Apgar score from 8-10 have foetuses born using the methods of assistance by Bracht/Lowset and Bracht (83 85%) with high statistical significance in comparison with other three methods of manual assistance (p<0.001). There is no statistical significance concerning Apgar score between the methods of Bracht/Lowset and Bracht (p=0.59). Conclusion: By using the adequate manual assistance which is the least traumatic for the foetus we achieve better postnatal prognosis. 
INCIDENCE OF HELICOBACTER PYLORI INFECTIONS AMONG THE PATIENTS WITH ULCER AND NON-ULCER DYSPEPSIA
Authors: Stalević Lj. , Popović M. , Aleksovski D. , Mitić J. , Sotirović D.
Published: November 2024

Helicobacter pylori infection is the largest number of infected people in the world. It is believed that 50 - 60% of world population infected, but with uneven schedule. Helicobacter pylori is the most important cause of duodenal and gastric ulcer. The prevalence of infection in different communities vary depending on geographic, racial and socioeconomic factors, and the last 10-20 years in some areas can be observed a significant reduction in the frequency of infection in both the general population and among patients with peptic ulcer. In our country, except in the territory of Vojvodina, there was no serious investigation of frequency of Helicobacter pylori infection in the general population.
DERMATOGLYPHIC CHARACTERISTICS AND CHROMOSOME ABERRATIONS OF AUTOSOMES
Authors: Sretić Lj.
Published: November 2024

Dermatoglyphs are epidermal ridges on the volar surfaces of fingers, toes, palms and soles.Their development begins between 6th and 7th gestational week, so that critical stage of ridge differentiation occurs in the first trimester, coinciding with critical phase of embryonal development. The inheritance of epidermal ridge patterns is polygenic, often markedly affected by some environmental factors causing them to be reffered as multifactorial traits. Genetic determination, time of occurrence, stability and high individuality enable dermatoglyphic analysis to give an insight in critical stage of embryogenesis. Unusual dermatoglyphic variables are found to be significant markers in many numerical and structural chromosomal aberrations .Many investigations have proved epidermal ridges configuration analysis as a powerful additional screening method in identification of congenital anomalies, detection and prevention of different genetically caused disturbances.
THE POSSIBILITY OF USE OF INCRETINS IN DIABETES MELLITUS II THERAPY
Authors: Soldat-Stanković V. , Vuković B. , Ristić S. , Bojić M. , Ristić S. , Mališ S. , Medenica S. , Mirić M.
Published: November 2024

Type 2 diabetes represents a progressive disease, primarily characterised by impairment of glycoregulation, despite the application of various therapy modalities. The main problem with type 2 diabetes, is progressive impairment of betacell functioning, and impairment of insulin resistance. There is an ongoing pursuit after adequate therapy modalities aiming at preservation of beta-cell function followed by loss of weight and assurance of good glycoregulation. For mentioned reasons, research has been done recently on the functioning of enteropancreatic axis in type 2 diabetes. It has been noted that oral intake of food or glucose leads to higher increase in secretion of insulin in comparison to the intake of the same quantity of glucose intravenously, resulting in assumption that hormone signals from endocrine cells of intestine released by the intake of food represent potent stimulators of insulin secretion. Such role is played by GLP-1 and GIP, GIT peptide hormons which stimulate secretion of insulin and release themselves into blood when stomach himus penetrates into duodenum, that is before glucose from himus is absorbed into internal body media. Persons with type 2 diabetes have got low level of secreted GLP-1 after meal. Chronic administration of GLP-1 agonists leads to reducing glycemia and HbA1c. The potential of GLP-1 agonists to decelerate progressive decay of beta-cells at diabetics is alluring, but insufficiently documented. DPP-IV inhibitors represent complementary approach for provoking incretin effects, by oral intake of pills.
HYDATIDE CYST OF THE EXTRAHEPATIC BILE DUCT - CAUSE OF THE OBSTRUCTIVE JAUNDICE (CASE REPORT)
Authors: Lazović R. , Bajić P. , Dobričanin V.
Published: November 2024

Hydatid disease is a parasitic infestation by a tapeworm of the genus Echinococcus which represent significant healthcare problem in Montenegro as in many other regions of the earth. The incidence in Montenegro is 4.57/100.000. Communications with bile ducts is one of the most frequent complications of the hydatid disease. Wide communications can be followed with cholangitis and obstructive jaundice. We presented 51 years old patient with obstructive jaundice and hydatid cyst of the liver. Total pericystectomy is golden standard of the surgical treatment, which is, unfortunately possible only in 6-10% of the cases. The usage of the intraoperative ultrasound is standard procedure.
HYDROPNEUMOTHORAX - CASE REPORT
Authors: Jovanović T. , Nikolić S.
Published: November 2024

Hydropneumothorax is a patological condition of pleura characterised by presence of both liquid and air, rarely of gas between two pleura laminae.According to the origin,it can be result of a disease or a trauma. A typical roentgenogram is obtained during radiography in a standing position and PA projection: horizontal level of liquid represented by homogeneous shadow merging with diaphragm shadow and avascular light without visible parenchyma above the liquid level. The authors present two cases of hydropneumothorax. The first case is about hydropneumothorax originated after several repeated tapping of pleural effusion of malignant etiology. In the second case, hydropneumothorax is a thorax injury complication. Hydropneumothorax rarely appears in practice, and diagnosis is fast and accurate just based on clinical picture and standard lung radiography.
THE INFLUENCE OF DOMINANCE OF A HAND WHEN PERFORMING THE ODDBALL TASK ON EVENT-RELATED POTENTIAL P300
Authors: Biševac B. , Ivetić V. , Milovanović Z. , Nestorović V. , Smiljić S. , Mišolić M. , Miletić M.
Published: November 2024

Event-related potential which represents a large positive wave which varies in amplitude and depends on subject's capability as well as on stimulus modality on which subject needs to react and appears around 300 ms after stimulation is called event related potential P300. In 1965. Sutton and the assistants were the first to suggest division of evocated potentials, according to the stimulus that provoke them, on "exogenous" (under the influence of exogenous stimulus) and "endogenous" or "cognitive" provoked by endogenous stimulus, which depends on the state of consciousness (vigilance), attention, concentration and especially, the type of the task a subject needs to perform during the recording. One of the most studied responses of the event-related potentials is so called "P300", the late positive wave complex which appears around 300 500ms after the stimulus. It is gained when the subjects' attention is focused on the signal which rarely appears, especially if the signal has some emotional or motivational meaning. The aim of this work was to determine whether there was a difference in latency and amplitude of the event related potential P300 when the button is pushed with dominant hand compared with nondominant hand in both males and females. The experiment included 30 subjects (15 males and 15 females). P300 potential was provoked with the auditive "oddball" paradigm. Event-related potencial P300 is recorded with 10-20 system. Cz electrode is set in the middle of nazion-inion line, while Fz electrode is set on the third of nazion-inion line above frontal lobe. In classical "oddball" paradigm, when a subject reacted on the signal by pushing the button with dominant hand, the value of Fz end Cz latency was significantly shorter in comparison to the values of Fz end Cz latency gained by pushing the button with non-dominant hand (left hand) in males, while such differences were not found in females. 
IMPORTANCE OF SELF-RATED HEALTH AS A HEALTH INDICATOR
Authors: Mirković M. , Simić S. , Marinković J. , Parlić M. , Parlić M. , Ćorac A. , Ðurić S.
Published: November 2024

Because of significance of self-rated health as a valid measure of health status it is important to research what influence on individuals when they assess own health.. The aims of the study were to investigate how north Kosovska Mitrovica adults describe their health and to compare results with results from Serbia without Kosovo and Metohija; and to determine which variables are connected with self-rated health status among this population. The research was conducted as crosssectional study, done on the representative sample of adult citizens in northern Kosovska Mitrovica in the year 2006. 318 examinees were examine. The instrument of research was a questionnaire which contained questions about self-rated health and demographic and socio-economic characteristics, mental health, social interaction, capability of daily activities, health behaviour and habits, diseases and injuries, utilization of health care service. Independent variables are defined through fac2 tor analysis taken from these groups of question. For statistic analysis were used X -test and multivariate stepwise linear regression. More than half of the respondents (54,7%) their health assessed as good or very good. Inhabitants of northern Kosovska Mitrovica were significantly often their health assessed as good or verz good than inhabitants of Serbia without Kosovo and Metohija (p<0,05). Self-rated health were connected with foreword variables: gender, mood problems, myocardial infarction, chronic bronchitis, psychic and neurotic disorders, rheumatic arthritis, high blood sugar, utilization of private gynecologist service and paying for diagnostic service. Results from this study correspond with findings from literature. Most of the respondents in north Kosovska Mitrovica assessed their own health as good or very good. Bad and very bad health was significantly associated with females, problems with mood, myocardial infarction, chronic bronchitis, psychic or neurotic disorders, rheumatic arthritis and high blood sugar. Good and very good health was significantly associated with utilization of private gynecologist service and paying for diagnostic service. 
THE COMPARATIVE ANALYSIS OF MORPHOLOGICAL DIMENSIONS OF FIRST-CLASS
Authors: Popović-Ilić T. , Stanković V. , Vitošević B. , Ilić S.
Published: November 2024

The aim of the research was to use a system of 25 variables of morphological characteristics on a sample of subjects numbering 200 top athletes, all males (50 handball players,50 volleyball players, 50 basketball players, 50 soccer players), aged 18 to 30, in order to determine their factor structure, which would be in aid of more rational procedures for the continual selection of athletes in these sports and the transformational training process. By means of the component analysis (the direct oblimin) and the GK criterion (ë≥1.00) used to obtain the common characteristic roots and the explained segments of common variance, five latent variables were isolated for the handball players (body mass and voluminosity and the subcutaneous fatty tissue of the upper body, the longitudinal dimension of the skeleton, the subcutaneous fatty tissue of the lower extremities and upper àrm, the transverse dimension of the lower extremities, the transverse dimension of the elbow and shoulder), six latent variables for the volleyball players (the transverse dimension of the wrist and body volume and mass, subcutaneous fatty tissue of trunck, longitudinal dimension of skeleton, the transverse dimension of knee and foot length, lower leg skin folds and fatty tissue of the upper arm,elbow diameter), another five latent variables for basketball players (the longitudinal dimension of the skeleton, body mass and voluminosity and subcutaneous fatty tissue of the trunck, the subcutaneous fatty tissue of the lower extremities and upper arm, transverse dimension of the lower extremities and the wrist, the transverse dimension of pelvis) and six latent variables for the soccer players (the longitudinal dimension of the skeleton, the subcutaneous fatty tissue of the lower extremities and upper arm, body mass and voluminosity, the transverse dimension of the legs, shoulder and hand, the subcutaneous fatty tissue of the trunck, transverse dimension of the arms). On the basis of the identified factor structures of the latent variables, it can be concluded that we are dealing with a case of different morphological structures of the different athletes. 
VITAL PROCEDURE ON MULTIROOT TEETH OF LOWER JAW
Authors: Šubarić Lj. , Živković M. , Matvijenko V. , Perić D. , Živković D. , Jovanović R. , Šehalić M.
Published: November 2024

Vital extirpation is microsurgical intervention.Wellknowing of internal morpfology of pulp cavity and with patience, carefull and precise work is possible to extirpate, dilatate and fil in both distal and mesial root of down molars,even if in mesial root exists two canal (buccal and lingual) what is the ruosh aften finding. Vital extirpation is very frequenthy used method in the treatment of multi-root teeth.It is more requested intervention tlak usnal once,but patients mane less visits at the dentist and the results one good enongh. So, one session method isacceptable as from medical point of view but endodontic too.
GROWTH HORMONE: OF THERAPY TO DOPING
Authors: Vitošević B. , Jovanović A.
Published: November 2024

Because of it’s anabolic and lipolytic effects and with the beginnings of the production of recombinant growth hormone for the treatment of many congenital diseases began and growth hormone abuse in sport. His contributions to enhancing the physical performances of athletes are debatable, and there are many side effects. Detection of growth hormone use as doping agents is impossible by standard means of doping because of the identity of its recombinant and natural forms. There are various tests measuring its isoforms and collagen peptide, while the use of carbon isotope is still under investigation. Efficient detection tests, the use of "athlete passport" and education of athletes, are good way to prevent misuse of growth hormone.
POSSIBILITIES OF TREATMENT IMPACTED CANINES - Case report
Authors: Pavlović J. , Tabaković S. , Vujačić A. , Vukićević V. , Simić S. , Dubovina D.
Published: November 2024

Introduction: Most permanent teeth erupt and establish proper occlusion. In some cases, the permanent teeth have a problem in the eruption and remain impacted in bone.There are two possibilities. 1. Extraction of impacted tooth and its replacement implant or a prosthetic replacement, 2. Surgical release of the impacted teeth and orthodontic traction in the dental arch. The time of treatment, type of surgery release impacted teeth, orthodontic techniques and possible problems during treatment, depending on the type of the impacted tooth and its location. Case report: Clinical examination 14-year-old patients concluded the lack of maxillary canine teeth in the dental arch. Panoramic image showed bilateral canine impaction in the upper jaw. The analysis of X-ray image was recorded axial and in the middle alveolar position of both the impacted tooth. This is why we chose the of closed eruption method. Discussion: Impacted maxillary canines, the middle alveolar ridge treated by closed eruption, except for a slight increase in clinical crown of the tooth does not show other changes deteriorate.
PROSTHETIC REHABILITATION MALOCCLUSION CLASS III- CASE REPORT
Authors: Đorđević N. , Ajduković Z. , Petrović B.M. , Milićević J. , Mitić A. , Živković D. , Živković M.
Published: November 2024

Treatment, rehabilitation and aesthetics should be the main tasks of modern dentistry. Adequate prosthetic therapy and rehabilitation may be conditioned by different factors. The paper describes prosthetic rehabilitation of a patient, 55 years old woman, with abnormalities in the vertical dimension of occlusion and malocclusion of the third class, and all in order to return of aesthetics and the function of stomatognathic system. The patient came to the clinic due to disturbed aesthetics and function, where was achieved the appropriate amount of bite along with satisfactory aesthetics and functional results due to a combination of fixed and partial dentures. Two metal-ceramic bridges consisted of 13 pieces were built in the upper jaw, and 8 teeth mobile partial denture in lower jaw, thus resulting in satisfactory requirements set to re-establish aesthetics and function of stomatognathic system. 