bluuebunny/crossref_metadata_2025 huggingface dataset:
Navigating the Spectrum of 4 Evidence-Based Nutrition Options for Type 2 Diabetes Management
Authors: Baskin Revital Gorodeski , Karp Kimberly A
Published: February 2025

Context

Type 2 diabetes mellitus is a complex, pervasive disease that creates a health and financial burden. The goal is to head off progression to insulin requirement, and dietary changes have been recognized as a first-line intervention in the treatment protocol. Four evidence-based nutritional options are reviewed and their benefits for metabolic consequences.

Evidence Acquisition

We conducted a comprehensive search of relevant literature using the PubMed database for recent systematic reviews, meta-analyses, and original research articles.

Evidence Synthesis

The Mediterranean and plant-based diets have demonstrated benefits for the prevention and treatment of diabetes, weight reduction, lipid improvements, and overall cardiovascular risk reduction. A low carbohydrate diet is another viable option for hemoglobin A1c (HbA1c) reduction, though it is not as uniformly defined and is difficult to maintain long term. The ketogenic diet is similarly very restrictive and produces significant HbA1c reductions.

Conclusion

Type 2 diabetes prevention and treatment is crucial in this widespread disease. The first-line treatment is lifestyle modifications with dietary interventions being at the forefront. With a unique clinical model and a variety of dietary options, our program strives for individualized evidence-based care. Nutritional modifications are the best initial approaches to overcoming insulin resistance and hyperinsulinemia. All dietary modifications, like any medical intervention, require education on benefits vs risks.
Insights on Improving Health Insurance Literacy in Diabetes
Authors: Blanchette Julia E , Nally Laura M , Wentzell Katherine , Hughes Allyson S , Allen Nancy A , Litchman Michelle L
Published: February 2025

Context

Many adults with diabetes cannot afford medications or health care and have low health insurance literacy, resulting in psychological distress and barriers to optimal self-management.

Objective

This mini-review aimed to explore the effectiveness of health-insurance literacy interventions and provide recommendations for diabetes practice.

Methods

We conducted a thorough search of relevant PubMed and Scopus studies from 2014 to 2024. Our inclusion criteria were interventions or pilot intervention studies using the search terms “health insurance” OR “health insurance literacy” OR “population (oncology, young adults/college/university students, and adults).” We then meticulously analyzed the quality of these studies, and assessments were conducted in Excel. We synthesized the evidence on interventions used to support health-insurance literacy across chronic health conditions and the general population, and their applications to diabetes care. Our findings showed effective interventions address a population's specific learning needs and literacy level. Multiple/diverse methods were used, including web-based decision aids, virtual sessions, hands-on support from navigators, Serious Games, educational workshops, and online microvideo Toolkits. Critical gaps included defining and measuring health-care literacy.

Conclusion

Solutions for health-insurance education include strategies to incorporate education into academic curricula, diabetes transition programs, community health fairs, and employing community health workers within health-care systems. Although there is a validated health insurance literacy measure, consistent use of this measure across future programs can further the critically needed science in this field.
Navigating Insulin Options for Diabetes Management
Authors: Rafi Ebne , Tranchito Lily , Hatipoglu Betul
Published: February 2025

Context

Insulin therapy is first-line therapy for people with type 1 diabetes and often used for people with type 2 diabetes. Over the years, there has been a surge in insulin products available for use. As a result, clinicians need to have a strong understanding of the differences between insulin agents to provide proper patient care.

Evidence Acquisition

We included population-level data and searched PubMed and Google Scholar databases for recent systematic reviews, meta-analyses, and original research articles.

Evidence Synthesis

Patients who present with severe hyperglycemia or signs consistent with a catabolic state such as weight loss or ketonuria should be initiated on insulin. Furthermore, patients with a hemoglobin A1c (HbA1c) level >10% or an unclear diagnosis of type 1 diabetes should typically be treated with insulin. Insulin products differ mainly in their pharmacokinetic profiles and not mechanism of action. The literature suggests that differences in pharmacokinetics allow certain insulin products to be well equipped to address different clinical situations such as steroid-induced hyperglycemia, managing patients with severe chronic kidney disease or dialysis, and insulin pump therapy.

Conclusion

Understanding kinetic profiles of different insulin agents will allow clinicians to properly navigate options for either fasting or mealtime coverage. Furthermore, this foundational knowledge will be critical when applying insulin therapy in clinical scenarios such as steroid-induced hyperglycemia, kidney disease, and insulin pump management. Ultimately, this will allow clinicians and patients to create proper diabetes care plans and self-management skills.
SGLT2i and Cardiovascular Events in Patients With Concomitant Atrial Fibrillation and Diabetes: A TriNetX Cohort Study
Authors: Hsiao Yu-Yu , Chen Yun-Yu , Kuo Ming-Jen , Chien Yu-Shan , Li Guan-Yi , Wu Shang-Ju , Lin Wei-Lun , Chiu Shu-Fen , Li Cheng-Hung , Lin Jiunn-Cherng , Lin Ching-Heng , Huang Jin-Long , Hsieh Yu-Cheng , Chen Shih-Ann
Published: February 2025

Aims

Sodium-glucose co-transporter 2 inhibitors (SGLT2i) enhance cardiovascular outcomes in individuals with type 2 diabetes mellitus (T2DM). Whether such effects also occur in T2DM patients with atrial fibrillation (AF) remains unknown. We aimed to investigate SGLT2i use on cardiovascular outcomes in patients with concomitant AF and T2DM.

Methods

Patients with both AF and T2DM were identified from TriNetX, an international electronic medical record. Participants were divided into 2 groups according to their use of SGLT2i, at a 1:1 distribution through propensity score matching (PSM). The hazard ratio (HR) for clinical outcomes was determined using multivariate Cox hazards regression model.

Results

We studied 339 792 patients with AF and T2DM, with 32 945 (9.70%) SGLT2i users. Following PSM, 17 011 patients aged 68.4 ± 7.9 years were included in each group. After a 3-year follow-up, patients treated with SGLT2i showed significantly reduced risks of stroke (adjusted HR: 0.830, P < .001), dementia (adjusted HR: 0.662, P < .001), long-standing persistent AF (adjusted HR: 0.917, P < .001), heart failure (adjusted HR: 0.833, P < .001), and all-cause mortality (adjusted HR: 0.532, P < .001).

Conclusion

The use of SGLT2i was associated with reduced risks of stroke, dementia, long-standing persistent AF, heart failure, and mortality in patients with both AF and T2DM. SGLT2i may be considered as a potential first-line therapy for this population.
A tiered approach to exome sequencing analysis in early-onset Primary Ovarian Insufficiency
Authors: McGlacken-Byrne Sinéad M , Suntharalingham Jenifer P , Ishida Miho , Buonocore Federica , del Valle Ignacio , Cameron-Pimblett Antoinette , Dattani Mehul T , Achermann John C , Conway Gerard S
Published: February 2025

Context

Establishing the genetic basis of early-onset primary ovarian insufficiency (EO-POI, <25 years) is important, but defining variant pathogenicity is challenging.

Objective

To elucidate the genetic architecture of EO-POI in a unique, large cohort.

Setting

Young women with EO-POI (n=149; n=31 familial, n=118 sporadic) attending a specialist reproductive unit.

Design

Exome sequencing was performed. After filtering, variants were retained which were 1) rare/novel (minor allele frequency <0.01%); 2) predicted pathogenic/likely pathogenic; and 3) enriched in the cohort. Each variant was assigned to a category: Category 1, variants in Genomics England Primary Ovarian Insufficiency PanelApp genes (n=69); Category 2, variants in other POI-associated genes (n=355) or Category 1 variants following unexpected inheritance patterns; and Category 3, homozygous variants in novel candidate POI genes.

Results

A total of 127 Category 1 or 2 variants were identified in 74 different genes (heterozygous 30.9%; homozygous 9.4%; polygenic 21.8%). In familial EO-POI, 64.7% (11/17 kindred) had a Category 1 or 2 variant identified (homozygous: STAG3, MCM9, PSCM3IP, YTHDC2, ZSWIM7; heterozygous: POLR2C, NLRP11, IGSF10, PRKD1, PLEC; polygenic: PDE3A, POLR2H, MSH6, CLPP). In sporadic EO-POI, 63.6% (n=75/118) women had a variant identified (21.2% (n=25) Category 1; 42.4% (n=50) Category 2). Novel POI candidate genes (Category 3) included PCIF1, DND1, MEF2A, MMS22L, RXFP3, C4orf33, and ARRB1.

Conclusions

The genetic basis of EO-POI is complex and affected genes span ovarian developmental processes from fetal life to adulthood. Establishing the pathogenicity of individual heterozygous variants can be challenging. However, some women have clear monogenic causes, particularly in familial POI with autosomal recessive inheritance. Others have potential polygenic causes. We describe novel candidate POI genes warranting further exploration.
Single-cell landscape of peripheral blood mononuclear cells in patients with Graves’ disease
Authors: Wang Yixuan , Zhang Xinjie , Ge Junfeng , Jin Jiajia , Zheng Zhijian , Li Jiaxuan , Wang Xiaowei , Zhang Shucui , Wang Zhe , Dong Guangguo
Published: February 2025

Background

Graves’ Disease (GD) is a thyroid-specific autoimmune disease and the most common cause of hyperthyroidism. Its pathogenesis is associated with the disruption of immune tolerance and autoantibody production. However, the mechanisms underlying immune abnormalities remain incompletely elucidated.

Methods

We employed single-cell RNA sequencing (scRNA-seq) and analyzed 22680 peripheral blood mononuclear cells (PBMCs) from eight GD patients and twelve healthy controls.

Results

Our results unveiled the single-cell landscape of PBMCs in GD patients, revealing substantial heterogeneity and changes in the cellular composition and function of PBMCs. We observed an increase in the proportion of CD16+ NK cells and memory cells in T and B lymphocyte subsets. This increase was accompanied by significantly enhanced functions, including cell activation, immune/defense responses, and inflammatory reactions. Additionally, we detected changes in the activity of transcription factors in various cell types, which were linked to the regulation of genes critical for immune and inflammation responses. Furthermore, we found a reduction in communication between NK cells and other immune cells, including CD4+ T cells, monocytes, and B cells, mediated by KIR-like inhibitory receptors, suggesting their involvement in the pathogenesis of GD.

Conclusions

Our study revealed characteristic alterations in the composition and function of immune cell subsets in the PBMCs of GD patients. These findings shed light on the mechanisms underlying immune dysregulation in GD.
The Power of Education to Reduce the Carbon Footprint of Volatile Anesthetics in Clinical Practice
Authors: Schwiethal Arne , Treskatsch Sascha , Michael Jannis , Höft Moritz , Spies Claudia D. , Koch Susanne
Published: February 2025

BACKGROUND:

Due to their chemical nature as fluorinated hydrocarbon compounds, volatile anesthetics are highly potent greenhouse gases, with desflurane having by far the largest CO2-equivalent (CO2e) footprint. In everyday clinical practice, the CO2e footprint can easily be reduced through the increased use of propofol or sevoflurane as well as low- and minimal-flow techniques or through the more frequent use of regional anesthesia techniques. We wanted to assess to what extent educational measures on sustainability aspects of the use of volatile anesthetics had an impact on daily practice in anesthesiology departments and to what extent this influenced the hospital’s CO2e emissions.

METHODS:

We conducted an observational data analysis of the consumption of anesthetics (sevoflurane, desflurane, isoflurane, and propofol) at all 3 clinical Charité campuses in the period from 2015 to 2023. The CO2e emissions were calculated for sevoflurane, desflurane, and isoflurane. External and internal (top-down or bottom-up) educational measures focusing on sustainability in anesthesia took place from September 2018 on. Shifts in CO2e emissions related to the educational measures are shown in a run chart. The number of surgeries, surgery duration, and purchasing costs were included in the analysis.

RESULTS:

CO2e emissions of volatile anesthetics were reduced by 90.3% from the baseline epoch (years 2015–2017) before educational interventions took place to 2023: CO2e 1470 tons (mean 2015–2017), to 191 tons (2022) to 142 tons (2023). This change was brought about by the phasing out of desflurane and the use of propofol or sevoflurane and regional anesthesia where appropriate. The fastest and most sustainable changes were seen after internal top-down measures. The total cost of anesthetics also fell over the period under review (from €541,102/$594,238 in 2015 to €281,646/$309,303 in 2023).

CONCLUSIONS:

Educational measures for anesthesiologists about the climate-damaging effects of volatile anesthetics—especially desflurane—can significantly reduce CO2e emissions in anesthesia clinics. On the positive side, these measures have also reduced the annual costs for anesthetics.
We Need New Screens
Authors: Olofinlua Temitayo
Published: February 2025

The internet is changing the face of screen media across the continent. In this chapter, this change is captured through the lens of a continental television series, MTV Shuga. By exploring how the show adapts its use of the screen to speak to its young audience, the “mobile screen” is redefined. It is not just a screen for viewing but also a screen through which the audience become “moved” to action. Through the new frames, this chapter shows how this new screen is changing not only form but also its audience, who are no longer just passive viewers but also content creators, producers, spreaders, and active participants in the making of the films. Grounded in examples drawn from the television show, the chapter shows how this “new media” is drawing the audience in and birthing a different kind of screen.
From Infrastructures to Treehouses
Authors: Bud Alexander
Published: February 2025

Since 2010 a landscape of circulations and “infrastructures” has dominated Nollywood studies. This chapter puts forward an approach in which the flows are more contingent, less directed and “leaking out” at every stage in a film’s life cycle, during both production and reception as well as distribution. The first part of the chapter looks at location filmmaking in Igboland, exploring the flows through a scene populated by filmmakers, on- and off-duty actors, location managers, owners of the houses where films are shot, and other house owners who incorporate filmic images into their homes. The chapter then explores the recent phenomenon of studio production in Lagos, including fabricators working on film sets (set designers, carpenters, painters), and those in the wider world (such as architects, interior designers, and furniture makers). The conclusion crystalizes the approach in the idea of the “treehouse” as a counterpoint to “infrastructure.”
Afterword 1
Authors: Jedlowski Alessandro
Published: February 2025

Responding to the chapters included in Contemporary African Screen Worlds, this afterword formulates a few reflections aimed at pointing out further directions for future research in the field of African screen media. It points in particular at the need to further investigate the political dimensions of technological innovation and the ambiguous role played by African states in relation to the transformations that such innovation provoked. It also highlights the conceptual fertility of the notion of “screen media worlds” adopted in this collection, and its potential for inspiring future research on southern screen cultures, beyond the narrow (and at times misleading) boundaries of world cinema and African cinema studies.
Advanced Footwear Technology, but not Acute Ingestion of a Ketone Monoester, Improves Running Economy in Middle- and Long-Distance Runners
Authors: Brady Aidan J. , Moynagh Megan B. , Devenney Simon , Egan Brendan
Published: February 2025

Purpose

This study examined the separate and combined effects of advanced footwear technology (AFT) and acute ingestion of a ketone monoester on running economy (RE), time-to-exhaustion (TTE), and other metabolic and cardiorespiratory parameters.

Methods

In a four-condition, placebo-controlled, randomized crossover design, 18 middle- and long-distance runners (male/female, 10/8, V̇O2peak: 59.4 ± 7.2 mL·kg-1·min-1) completed five 8 min stages of submaximal running (male: 10–14 km·h-1; female: 9–13 km·h-1) on a motorized treadmill, immediately followed by a ramp test to volitional exhaustion. Participants consumed 500 mL of either a 10% carbohydrate solution (CHO) or 500 mg·kg-1 body mass of an (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester with flavored water (KME) 20 min before exercise, and an additional 300 mL of the 10% carbohydrate solution or 250 mg·kg-1 body mass of KME during exercise, while wearing either Nike Pegasus Turbo (PEG) or Nike ZoomX Vaporfly Next% 3 (VAP) running shoes. The four randomized conditions were PEG+CHO, PEG+KME, VAP + CHO, and VAP + KME.

Results

RE was significantly improved during the third and fourth submaximal running stages in VAP + CHO and VAP + KME compared to PEG+CHO and PEG+KME (all P < 0.05; ES = 0.53-0.84). RE was also improved during the fifth submaximal running stage in VAP + KME compared to PEG+CHO, and in VAP + CHO and VAP + KME compared to PEG+KME (all P < 0.05; ES = 0.56-0.66). No differences in RE were found between CHO and KME conditions. TTE was significantly longer in VAP + CHO (381 ± 125 s) than PEG+CHO (356 ± 140 s; ES = 0.18, P = 0.023) and PEG+KME (329 ± 131 s, ES = 0.40, P < 0.001) and in VAP + KME (375 ± 125 s) than PEG+KME (ES = 0.35, P < 0.001).

Conclusions

AFT, but not the acute ingestion of a ketone monoester, improved the RE of trained male and female middle- and long-distance runners at submaximal running speeds.
Solving Heat Stress in Sport: Intermittent Cold Air Exposure Mitigates Deterioration of the Autonomic Nervous System in American Football Athletes
Authors: Renaghan Eric , Wishon Michael J. , Wittels Harrison L. , Hecocks Dustin , Galasso Peter J. , Ren Tom , McDonald Samantha M. , Feigenbaum Luis A. , Wittels S H.
Published: February 2025

Objectives

Cooling interventions mitigating heat-related declines in autonomic nervous system (ANS) function are understudied in American football.

Methods

This study exposed fifty, collegiate male athletes during their 2023 season to two bouts of cold air via air-conditioning prior to (60 mins) and during (5 min) training sessions in a hot and humid climate. Armband monitors, (Warfighter MonitorTM, Tiger Tech Solutions, Inc., Miami, FL, USA), were used to continuously measure core temperature (°C) during training and baseline heart rate (HR), HR recovery and HR variability (HRV) 24 hours post training. Two HRV time-domain indices were estimated: root mean square of the standard deviation of the NN interval (rMSSD) and the standard deviation of the NN interval (SDNN). These data (2023) were then compared to data collected throughout the previous season (2022) during which players were not provided a cold-air intervention. As such, the 2022 cohort served as a “control” group.

Results

Linear regression models no statistically significant associations at the following core temperature thresholds: ≥ 37.0 °C (baseline HR: p = 0.74; HR recovery: p = 0.71, rMSSD: p = 0.74; SDNN: p = 0.78), ≥ 38.0 °C baseline HR: p = 0.74; HR Recovery: p = 0.74; rMSSD: p = 0.68 and SDNN: p = 0.89) and ≥ 39.0 °C: baseline HR: p = 0.75; HR Recovery: p = 0.82; rMSSD: p = 0.78 and SDNN: p = 0.83). Compared to the 2022 season, the athletes spent considerably less time training under the higher core temperature thresholds (≥ 38 °C: 19.5 min vs 9.7 min; ≥ 39 °C: 10.5 min vs 0.9 min), respectively, despite longer overall training duration, (161.1 min vs 187.4 min).

Conclusions

Our findings suggest that incorporating bouts of cold air exposure when training in high heat and humidity may mitigate the established heat-related deterioration in ANS function.
Science at the Secretariat of the International Seabed Authority: post-normal science for recalibration of policy instruments.
Authors: klimašauskaitė aistė , Dees Paul , Funtowicz Silvio Oscar , Drivdal Laura Elisabet , Berta Ola G.
Published: February 2025

Post-normal conditions require post-normal resolutions. When stakes are high and values are disputed, policy discussions and decisions cannot rely on science alone. Such discussions require post-normal science, which centralizes the qualitative value of diverse knowledge groups. In this essay we discuss the usefulness of post-normal science in the context of the Secretariat’s work at the International Seabed Authority. In particular, we explore the need to expand the understanding of science and knowledge – key components informing deep-seabed policies. Marine science encompasses a broad range of research topics and interests – from blue humanities with analyses of human-Ocean relations, to physics of particulate matter, to marine policy research. The growing number of disciplines applied to marine science demonstrates our increasing collective knowledge of the Ocean and, in turn, our appreciation of knowledge limitations. Such knowledge challenges are discussed among natural and social scientists. The Secretariat depends on broad expertise, from natural sciences, social sciences, civil society and beyond. In sum, our thesis is the following: we argue that post-normal science can help metaphorically recalibrate policy-shaping instruments (the practice) so that decision-making processes and policy agendas are implemented for transformative actions.
Relacje semantyczne między okładką a treścią wybranych książek Marii Janion w perspektywie komunikacyjnej
Authors: Rawski Jakub
Published: February 2025

Celem artykułu jest analiza relacji semantycznych między okładkami a treścią wybranych książek naukowych Marii Janion. W tym kontekście ważne wydają się odpowiedzi na następujące pytania: w jaki sposób okładki woluminów badaczki oddają ich warstwę tematyczną? Czy zachodzi między nimi korelacja? Czy można postawić tezę o jedności znaczeniowej okładek i treści prac Janion? Wychodząc z założenia, że pierwsza strona okładki to jej część najbardziej reprezentatywna i ważna z uwagi na pierwszeństwo kontaktu autorem z czytelnikiem, warto podkreślić aspekt komunikacyjny. Interesującym zadaniem poznawczym jest typologizacja okładek ze względu na pojawiające się na nich elementy graficzne oraz określenie funkcji komunikacyjnych, które realizują. Niezbędne okazało się również określenie znaczeń generowanych przez okładki, czyli tego, jakie zwierają komunikaty, oraz wskazanie tematów, toposów, motywów, do których okładki nawiązują i które pojawiają się w książkach uczonej.
An Economic Model of a Decentralized Exchange with Concentrated Liquidity
Authors: Hasbrouck Joel , Rivera Thomas J. , Saleh Fahad
Published: February 2025

We develop an economic model of a decentralized exchange with concentrated liquidity (e.g., Uniswap v3 and v4), with a particular focus on the economics of liquidity provision. We demonstrate that providing liquidity for a risky/risk-free asset pool is comparable to investing in a covered call, except that the call option therein is sold at intrinsic rather than market value. Hence, when providing liquidity, liquidity providers forgo the time premium of the call option in exchange for fees, and thus equilibrium liquidity provision decreases in the time premium. Finally, we provide an expression for equilibrium liquidity provision that is useful for empirical work.

This paper has been This paper was accepted by Lin William Cong for the Special Issue on Digital Finance.
Change-Point Detection in Dynamic Networks with Missing Links
Authors: Enikeeva Farida , Klopp Olga
Published: February 2025

Unveiling Hidden Shifts: Detecting Change Points in Dynamic Networks with Missing Links

Dynamic networks are ubiquitous in a world increasingly driven by interconnected systems from social media platforms to financial transactions, transportation systems, and cybersecurity infrastructures. Unlike static entities, these networks evolve, often undergoing abrupt structural changes. Detecting these changes is essential as they can signal critical events, such as cyberattacks or shifts in user behavior.

The challenge becomes even greater when dealing with incomplete data, a common reality in large-scale networks. Missing links, from nonresponses or privacy concerns, create uncertainty, complicating the identification of structural changes.

The paper “Change-Point Detection in Dynamic Networks with Missing Links” tackles this issue with a robust framework based on the matrix CUSUM test statistic. This novel methodology is adaptable to expanding networks and resilient to missing data. It detects structural shifts with minimax optimality, ensuring theoretical robustness. Extensive simulations and real-world examples reveal that the proposed approach outperforms existing methods. It provides a valuable tool for monitoring dynamic networks, detecting fraud, and spotting emerging trends.
Development of ethanol analysis in cough syrup medicine by colorimetric method
Authors: Sultan Siti Fatimah , Susanti Hari , Mohamed Farahidah , Salamah Nina
Published: February 2025

Cough syrup is a pharmaceutical preparation often containing ethanol as a solvent. However, the presence of ethanol in the drug can cause safety issues. This study aims to develop and validate a colorimetric method for determining ethanol in cough syrup. Cough syrup samples from different brands were analyzed using the method. The Visible spectrophotometric method uses the oxidation reaction of ethanol with potassium dichromate in an acidic condition. Method validation was conducted, including linearity, precision, accuracy, limit of detection (LOD), and limit of quantification (LOQ). The results showed this method had good linearity (r > 0.99) with a concentration range of 0.48 – 5.76 % (b/v). UV-Vis spectrophotometric method showed good precision and accuracy with SD = 0.0014, RSD = 0.4046 %, and % recovery = 99.99 %, while LOD = 0.1074 % and LOQ = 0.3253 %. This study concludes that the colorimetric method can be used as a valid and complementary method for analyzing ethanol content in cough syrup, providing important information for producers and consumers regarding product safety.
 
Keywords: Analytical method validation, Cough syrup, Ethanol, Spectrophotometry.
Optimization of Glycerin and Sorbitol in Hand Sanitizer Cream with Centella asiatica (L.) Extract
Authors: Novela Yuven , Yuliani Sri Hartati
Published: February 2025

The use of alcohol-based hand sanitizers can cause dry skin. Centella asiatica (L.) extract can be used as an alternative to alcohol because it contains triterpenoids, especially asiatic acid, potentially an antibacterial and inhibitor of the SARS-CoV-2 virus. Cream is a preparation that can moisturize and protect the skin. Glycerin and sorbitol are humectants often used in cream preparations and have a large percentage in the cream preparation's formula so that they can affect the physical properties of the cream. This study aims to obtain the optimum composition range of glycerin and sorbitol and determine the effect of glycerin and sorbitol as humectants on the physical properties and stability of the hand sanitizer cream with Centella asiatica (L.) extract. The composition optimization was done using a factorial design method on two factors and two levels using the Design Expert 13 (free trial) application. The data on the physical properties and stability of the cream were statistically analyzed using a two-way ANOVA test at a 95% confidence level. The results of qualitative phytochemistry screening showed that the extract contained triterpenoid. The average test of physical properties and stability of physical properties meet the desired criteria: cream type O/W, viscosity 120–170 dPa.s., spreadability of 5-7 cm, shift of spreadability, and shift of viscosity below 10%. The optimum area shows that the formulas F1, FB, and FAB meet the desired criteria.
Standardization of Snakehead Fish (Channa striata) Concentrates Obtained from Sungai Itik Village, Kubu Raya District, West Kalimantan
Authors: Aulia Yunita Hananda , Andrie Mohamad , Wintari Wintari
Published: February 2025

Standardization is the method of identifying properties based totally on superb parameters to advantage the identical diploma of satisfaction. it has been proven that vitamins decided in snakehead fish (Channa striata) from herbal assets can be implemented as a possibility to hasten the recuperation of wounds. With the assistance of the techniques of freeze drying, this examination sought to set up the standardization of snakehead fish pay attention from Sungai Itik Village in Kubu Raya Regency, West Kalimantan as an uncooked material for prescribed drugs that treat wounds. Standardization carried out on concentrate samples consisted of specific and non-specific parameters. Specific parameters consist of organoleptic, water-soluble essence content, protein, and albumin. While the non-specific parameters tested were moisture content, ash content, acid-insoluble ash content, and drying shrinkage. The test results showed that the water content contained in snakehead fish was 7.21% ± 0.165, ash content was 10.47% ± 1.06, acid insoluble ash content was 1.40% ± 0.115, water-soluble essence content was 77.10% ± 0.54, dry shrinkage rate was 13.973% ± 0.193, the protein was 99.49% and albumin was 7.03 g/dl. The standardization parameters have not met all the tests so it can be said that snakehead fish concentrate has not met the standard and has not been standardized for natural wound healing medicinal ingredients.
Agroecologia: metamorfoses no cotidiano da Zona Norte do Rio de Janeiro
Authors: Morelato Rodrigo Rossi , Domingues Claudia
Published: February 2025

O artigo descreve como atividades comunitárias desenvolvidas por um grupo de moradores das favelas da Zona Norte do Rio de Janeiro operam uma metamorfose no cotidiano. Fruto de uma pesquisa participante, perseguiremos parte da história da cidade, as vicissitudes de um fragmento florestal e as atividades criativas de um grupo, os “verdejantes” da Serra da Misericórdia. Através do exemplo das transfigurações realizadas pela compostagem residencial, demonstraremos como a agroecologia praticada nas terras cariocas possui algumas das soluções criativas para conter a desertificação do planeta.
Corpo, desejo e afeto em Boa sorte, Leo Grande (2022), um filme de Sophie Hyde
Authors: Rocha Sandro Aragão , Fiel Arthur
Published: February 2025

Em nosso trabalho buscamos refletir, a partir do filme Boa sorte, Leo Grande, da diretora Sophie Hyde, como a relação entre corpo, desejo e afeto aparece no longa, e se imbrica na troca que Leo Grande e Nancy Stokes têm entre si, partindo de seus diálogos, dos textos corporais enquadrado pela câmera e de todos os outros elementos que compõe a obra. Para tal, nos baseamos teoricamente em Byung-Chul Han (2017; 2019), partindo de suas concepções de afeto e poder; em Paul B. Preciado (2017; 2022), tendo como mote suas reflexões, principalmente, sobre o corpo; Judith Butler (2016), quanto ao que concerne a perfomance, entre outros teóricos. Dividimos o ensaio em quatro partes, seguindo a ordem dos encontros que os dois protagonistas tiveram, utilizando-nos de um movimento de escrita que cresce no mesmo percurso narrativo do filme.
“Isso não é o meu Last of Us”: reencontros e conflitos da recepção da série
Authors: Soalheiro Marcela , Waltenberg Lucas
Published: February 2025

Long, Long Time, o terceiro episódio da adaptação televisiva do jogo The Last of Us retrata a relação amorosa entre Bill e Frank, personagens conhecidos que são reencontrados em nova posição de protagonismo. Os seus arcos narrativos aprofundados geram um tensionamento incômodo na comunidade de conhecedores do texto-fonte. Neste trabalho, vamos analisar como a recepção da versão desvela uma dinâmica de mobilização preconceituosa motivada pela rejeição da inserção de um arco inclusivo da comunidade LGBT cuja argumentação é construída através de uma pretensa busca pela fidelidade ao texto-fonte no processo adaptativo.
ENSINO DE SÓLIDOS GEOMÉTRICOS NA EDUCAÇÃO DE JOVENS E ADULTOS COM USO DA REALIDADE AUMENTADA
Authors: Santiago Paulo Vitor da Silva , Cleuton de Araújo Francisco , Costa Dantas Wyanna Mara
Published: February 2025

O presente estudo analisa o impacto da Realidade Aumentada (RA) no ensino de sólidos geométricos na Educação de Jovens e Adultos (EJA), buscando compreender não apenas sua previsão técnica, mas também sua contribuição para uma aprendizagem significativa e contextualizada . Uma pesquisa, de abordagem qualitativa, foi realizada com alunos do 8º e 9º anos do Ensino Fundamental na modalidade EJA, com idades entre 18 e 50 anos , utilizando atividades práticas e o aplicativo Sólidos RA para a exploração de conceitos geométricos. Os resultados indicam que a RA, além de fornecer uma abordagem inovadora e atraente, possibilita a ressignificação dos conceitos matemáticos ao aproximá-los da realidade dos estudantes. A tecnologia favoreceu a compreensão de sólidos geométricos ao oferecer visualização interativa tridimensional, permitindo que os alunos estabelecessem relações entre os conceitos matemáticos e sua aplicação cotidiana. No entanto, observou-se que a eficácia da RA no ensino da EJA não pode ser reduzida à memorização de nomenclaturas e classificações, sendo necessário considerar sua capacidade de estimular o pensamento crítico e a autonomia dos estudantes. Dessa forma, a integração da RA ao ensino de sólidos geométricos na EJA se apresenta como uma ferramenta potencialmente transformadora, indo além do aspecto tecnológico para promover uma experiência educacional mais contextualizada, engajadora e significativa.
ACUMULAÇÃO POR DESAPROPRIAÇÃO, EXTRATIVISMO, ÁGUA E FRATURA METABOLICA
Authors: Gómez Lende Sebastián
Published: February 2025

O mundo está próximo do limite de esgotamento tanto da água doce quanto dos combustíveis fósseis, dois problemas que têm como eixo comum a exploração de hidrocarbonetos por fraturamento hidráulico. Com base nos conceitos de acumulação por desapropriação, fratura metabólica e a segunda contradição do capital, este trabalho analisa a relação entre água e fracking em Vaca Muerta, principal formação de recursos não convencionais da Argentina e uma das mais importantes do mundo. Para isso, utiliza estatísticas públicas oficiais, relatórios empresariais, relatórios de organizações ambientais, literatura acadêmica especializada e informações jornalísticas. Os resultados mostram inconsistências significativas nas fontes sobre o consumo de água das operações de hidrocarbonetos não convencionais na região, uma política tarifária muito distante dos padrões internacionais sobre o assunto e o crescente surgimento de conflitos hídricos entre o capital, o Estado e a sociedade civil sociedade onde o protesto social gerado pela fratura metabólica da relação água-comunidade desafia a narrativa hegemônica.
METODOLOGIA PARA PRÉ-PROCESSAMENTO DE MODELOS DIGITAIS DE ELEVAÇÃO
Authors: Da Paixão Marques Filho Jorge , Lima Silva Sonia Maria , Castilho da Costa Vivian
Published: February 2025

A disseminação de dados altimétricos, através dos Modelos Digitais de Elevação (MDE), permitiu o avanço de diversas áreas científicas, mais especificamente a Geomorfometria. No entanto, o MDE pode apresentar ruídos, comprometendo os resultados finais. O presente artigo tem como objetivo propor uma metodologia para pré-processamento de MDE, que otimize o processo subsequente de geração de variáveis morfométricas. A metodologia proposta consistiu em: a) controle de qualidade altimétrica; b) preenchimento das depressões espúrias; e c) aplicação de filtros. Dentre os MDE avaliados, o NASADEM foi o que obteve melhor precisão altimétrica. O algoritmo Fill Sinks possibilitou melhor remoção de depressões espúrias e o filtro passa-baixa de mediana, com janela móvel de 7x7 pixels permitiu melhor identificação das formas de relevo da área de estudo. Os métodos se mostraram adequados para áreas de estudo que apresentem heterogeneidade geomorfológica.
ORIENTANDO-SE AOS PRIVILÉGIOS
Authors: Lessa Weber Ingrid
Published: February 2025

Pesquisas no âmbito da justiça ambiental tendem a focar predominantemente em grupos vulnerabilizados. Embora de relevância inquestionável, esta abordagem é limitada. Tendo em vista que o direcionamento do olhar aos privilégios é importante para a compreensão da totalidade dos mecanismos que produzem e reproduzem cenários de injustiça ambiental, esta revisão de literatura foi realizada com o objetivo de compreender o estágio atual de conhecimento sobre como as classes média e alta acessam e/ou atraem, de forma privilegiada, proteção, recursos e amenidades ambientais para seus locais de moradia. Foram revisados 27 artigos publicados, em língua inglesa, de 2000 a 2023. As buscas foram realizadas no Portal de Periódicos da CAPES e retornaram, sobretudo, artigos que se aproximam da literatura da justiça ambiental, ecologia política e/ou desigualdade ambiental. Acessos privilegiados a vantagens ambientais variadas foram identificados em diferentes países, além de referências aos privilegiados com base em raça e classe. As evidências demonstram mecanismos variados de viabilização de vantagens ambientais atuando em diferentes escalas, tempos históricos e intensidades, e reforçam a necessidade, para além da promoção de amenidades ambientais em locais desfavorecidos, de combate a mecanismos de acesso privilegiado ao meio ambiente que resultem em impactos negativos a outros grupos de pessoas.
AMBIENTALISMOS MINERÁRIOS
Authors: Araújo Aline , Milanez Bruno
Published: February 2025

Neste artigo, argumentamos que o setor mineral tem sucessivamente se apropriado de elementos do discurso ambiental hegemônico, e cooptado argumentos apresentados pelos seus críticos como forma de construir legitimidade e garantir a perpetuação de seus interesses econômicos. Em razão disso, o objetivo central do presente texto é descrever o processo de construção de um discurso ambiental pelo setor mineral, propondo-se caracterizar os Ambientalismos Minerários e suas modificações, desde meados da década de 1990 a 2020. Para isso, foi realizada análise documental, utilizando do International Council on Mining and Metals (ICMM) como objeto de análise. Observamos que a construção dos Ambientalismos Minerários é consequência de uma concepção neoliberal de proteção da natureza, a qual vem permitindo que agentes econômicos diretamente relacionados à degradação de territórios sejam apresentados como centralidade para solucionar a crise ambiental-climática. Essa contradição, explicitada pela adoção de argumentos desde o desenvolvimento sustentável à transição energética, além de não ser capaz de solucionar as crises enfrentadas, impõe riscos para as regiões mineradas.
APRESENTAÇÃO
Authors: Grandi Matheus da Silveira
Published: February 2025

Apresentação do V. 21, N1 da Revista Tamoios.
Percepción de los estudiantes sobre la importancia de la resiliencia en la labor profesional de los trabajadores sociales: propuesta de un modelo de mediación
Authors: Salvador-Ferrer Carmen María , Rodríguez-Fernández Ascensión G , Jurado-Pérez María Daniela
Published: February 2025

La resiliencia es un componente relevante para afrontar los retos del mercado laboral. En este trabajo, nuestros objetivos son conocer la percepción de resiliencia que tienen los/as estudiantes de Trabajo Social y, también, proponer y probar un modelo de Mediación mediante el cual la perseverancia tiene un efecto mediador entre la satisfacción personal y la confianza en sí mismo. Utilizamos la escala de Wagnild y Young, en una muestra de 102 estudiantes del Grado en Trabajo Social. Los resultados de mediación simple ponen de manifiesto que la perseverancia tiene un efecto indirecto sobre la influencia de la satisfacción personal en la auto-confianza. Los datos muestran la relevancia que tiene la resiliencia para los/as estudiantes del Grado en Trabajo Social. Además, el peso que obtienen la auto-confianza, satisfacción y perseverancia. Descubrimos que la perseverancia es una variable mediadora en la relación entre la satisfacción personal y la auto-confianza
Embedding the new NMC proficiencies: Aligning standards with contemporary school nursing practice
Authors: Allan Elaine , Lloyd Erica , Flack Linda , Hayward Melanie
Published: February 2025

Elaine Allan, Erica Lloyd, Linda Flack and Melanie Hayward discuss what the introduction of the updated NMC proficiencies mean for school nursing practice and the importance of strong partnerships for their implementation.
How Do I Get to the Student Union? Developing Independent Navigation Skills in Students With an Intellectual or Developmental Disability
Authors: Mitchell Wendy R. , Deardorff Malarie , Sinclair Tracy , Wicker Melissa , McMillan Jeff
Published: February 2025

Navigating campus and the surrounding community may pose barriers to matriculation, engagement, and quality of life for students with disabilities. This intervention uses the student's smartphone device and a university map application to guide students as they navigate to specific destinations around campus (e.g., library, classroom buildings, restaurants, student union, and recreation centers). A single-case experimental withdrawal design (ABAB) was used to collect data for two participants. There was an immediate level change upon introduction of the intervention for both participants, indicating a functional relation. Results are suggestive that the presentation and application of wayfinding skills through technology can be successful and have the potential to support more independent lifestyles for persons with an intellectual or developmental disability.
Tiered Teacher Coaching to Promote Self-Determination in the Classroom
Authors: Kiblen Jessie C. , Shogren Karrie A. , Kurth Jennifer A. , Raley Sheida K.
Published: February 2025

Promoting self-determination has been shown to enhance outcomes for students with and without disabilities. The Self-Determined Learning Model of Instruction (SDLMI) is an evidence-based instructional model designed to promote self-determination in diverse contexts, including inclusive general education classrooms. SDLMI delivery requires training and ongoing support to enhance fidelity, teacher implementation skills, and positive student outcomes. Coaching supports the implementation and fidelity of an evidence-based instructional model, like the SDLMI. However, coaching supports must be tailored to implementers' needs. This article describes a three-tiered coaching model for the SDLMI that can inform teacher supports for effective SDLMI implementation. This three-tiered model expands the research-based SDLMI Coaching Model, providing a framework to individualize SDLMI supports to enhance teacher implementation and student outcomes.
Decadent Resistance in Colonial Korea: Kim Tong-in’s Artistic Subversion in “Fire Sonata”
Authors: Wu Di Cotofan
Published: February 2025

Abstract: This essay reinterprets Kim Tong-in’s short story “Fire Sonata” (1929) within the framework of “lyo-colonial decadence,” proposing it as a subtle form of resistance to Japanese colonial rule. By merging Western decadence, Japanese diabolism, and indigenous Korean expressions, the narrative critiques colonial oppression and explores themes of madness, trauma, and artistic autonomy. Through Kim’s portrayal of morbid artistry, the essay highlights how Korean intellectuals used decadence to reclaim personal sovereignty and critique both Japanese and Western cultural hegemony. This study contributes to the global understanding of decadence, revealing its capacity to adapt and resist within colonized literary traditions.
Symbolism and Mysticism: The Role of Maurice Maeterlinck in Arthur Symons’s Critical Vision
Authors: Dowthwaite James
Published: February 2025

Abstract: It has been little acknowledged that at the heart of Arthur Symons’s influential ideas about Symbolism was an intense engagement with the work of the Belgian playwright, Maurice Maeterlinck. In The Symbolist Movement in Literature (1899), Symons contends that Symbolism is the inheritance of a mystical tradition, and that its use of symbols is not directed to any particular doctrine or truth, but rather to mystery itself, to the human condition of being surrounded by an unknown metaphysical darkness. Symons identifies an aesthetics which represents this mysterious darkness most with Maeterlinck’s drama. This article traces their relationship from their first meeting in 1890 to Symons’s disillusionment in the early years of the twentieth century with the playwright, whom he felt had abandoned his mystical aesthetic in favor of rhetoric and logical clarity. Even this disillusionment shows the importance that Maeterlinck held for Symons as aesthete of the mystical.
Radical Victorians?
Authors: Mitchell Rebecca N.
Published: February 2025

Abstract: A review of the exhibition Victorian Radicals: From the Pre-Raphaelites to the Arts and Crafts Movement (February through Christmas 2024) at the Birmingham Museum and Art Gallery
High Speed Surface Acoustic Wave Imaging with Spectral Interferometry
Authors: Thomas Joseph , Xi Zichen , Ji Jun , Shi Guannan , Srijanto Bernadeta , Kravchenko Ivan , Yao Yu , Shao Linbo , Zhu Yizheng
Published: February 2025

We measure 1 gigahertz surface vibrations with spectral interferometry on a 76 kilohertz linescan camera. The vibrometer has a noise floor of 120 fm/sqrt(Hz) and images a 110 x 210 micron device in 10 minutes.
MFI and Demodulation in EON by ML Methods
Authors: Varasteh Ehsan , valizade morteza , Zefreh Mahdi , kashef sadra , Kamali Mirhadi
Published: February 2025

The demonstration of signals can be considered to be a critical function of new transceivers in elastic optical networks (EON). Transceivers can alter their bandwidth because of changes in the modulation formats, which are controlled by software. However, the non-linear fiber-optic channel poses a problem in the demodulation of the signal. This work focuses on the inherent intricacies of an EON and presents an approach to their improvement. We use Convolutional Neural Networks to predict modulation formats. In the subsequent stage of the demodulation, the focus is centered on the detecting symbol. Here, K-Nearest Neighbors and Support Vector Machines, with the generation of Rulemap images, produce the image as a decision boundary. In terms of numerical performance, the proposed method can improve the bit error rate by more than 25\% in some cases due to the low complexity of the suggested methods.