bluuebunny/crossref_metadata_2025 huggingface dataset:
Percepções de professores de ensino infantil e fundamental sobre os impactos da pandemia em sua rotina pessoal e profissional
Authors: Santos Camila Elidia Messias dos , Rodrigues Olga Maria Piazentin Rolim , Silva Nilson Rogério da , Capellini Vera Lucia Messias Fialho
Published: October 2024

O presente estudo objetivou descrever como professores do ensino infantil e fundamental perceberam e vivenciaram os impactos da pandemia no seu dia a dia pessoal e profissional, bem como comparar os dois níveis de ensino. Trata-se de uma pesquisa descritiva, tipo survey, com 74 professores, 34 do Ensino Infantil e 40 do Fundamental, de um município do interior do Estado de São Paulo, realizada por meio de formulário eletrônico composto por: a) Questionário de dados sociodemográficos e laborais e, b) Inventário minha profissão na pandemia. Os dados foram organizados por meio de frequência relativa e analisados estatisticamente. Os resultados apontaram impactos da pandemia nos dois segmentos e contextos analisados, principalmente relacionados à falta de equipamento tecnológico, tanto na escola como por parte das famílias, além do medo de contrair covid no retorno às aulas presenciais. Portanto, é necessária a formulação de novas condições de trabalho para os professores, considerando a infraestrutura física, o trabalho colaborativo e a formação continuada com base em recursos tecnológicos digitais.
Kants Sendschreibens zum Tod des Studenten Johann Friedrich von Funk (1760). Zur literaturhistorischen Einordnung — Teil 1: Gottsched und die Königliche Deutsche Gesellschaft zu Königsberg
Authors: Walter Martin
Published: October 2024

Kant’s mourning letter or necrology for his student Johann Friedrich von Funk (1760) has hardly been received. This study attempts to change this by explaining the contexts of the short missive. In the first part this concerns in particular the influence that Gottsched exerted on the style of such printed speeches or necrolo­gies. Kant’s references therefore to the ‘Royal German Society’ in Königsberg and its founder Flottwell, a friend of Gottsched’s, are described. The influence of the Roman Stoa then becomes much clearer through the influence of Gottsched’s rhetoric textbook. All in all, Kant attempts to present rational arguments for dealing with death, which can suddenly strike human life; he writes under the obvious influence of a Stoic mindset (see the second part). Most of the comments by Kant scholars on the little work to date have been negative or vague. Here, the text is to be made fruitful for the development of Kant’s thought by shedding light on its historical contexts. On this basis, the little treatise appears as an important link for Kant’s early thinking. It shows how he makes ancient tradition fruitful again for the Enlightenment as a substitute for rapturous and irrational mysticism as we know it from Jacob Böhme, for example.
Review of Recent Russian Studies of Hermann Cohen’s Philosophy
Authors: Lapshin Ivan Y. , Karagod Julia G.
Published: October 2024

The review covers scholarly publications devoted to the philosophy of Hermann Cohen, the head of the Marburg School of Neo­Kantianism, written by Russ­ ian researchers in the period between 2000 and 2023. Although Cohen commanded unquestioned authorityamong Russian philosophers of his time — among them some followers and pupils — there was no systematic and substantive study of his work in pre­revolutionary Russia. The review below attempts to show the evidentgrowth of interest in Cohen’s philosophy in the last quarter of the century. The teaching of the German philosopher who lived and worked in the late nineteenth and early twentieth centuries still attracts lively in- terest among Russian philosophers today. Witness the multiple monographs, articles and reports focusing on Cohen’s theory of cognition, his ethics and aesthetics, the search for convergences between the Christian religion and the Judaic tradition, the concept of the philosophy of culture, the relationship between morality and law and many other issues. The review pays particular attention to the works on the reception of Cohen’s philosophy in Russia, as well as previously unpublished translations and archive materials which were part of the scholarly discourse of his time but remained unpublished and then forgotten. The interest of modern Russ­ ian scholars in the work of Cohen does not only point to his importance for the history of philosophy, but attests to the relevance of his ideas whose potential has yet to be fully revealed. The review may serve as a guide to the published literature on Cohen for the students of his philosophy and for all those interested in Neo­Kantianism in general, thereby contributing to the development of such a field in philosophy as Cohen studies.
Análisis biomecánico del gesto técnico de la rondada en gimnasia artística
Authors: Cadena Peñafiel Tamara Julisa , Herdoiza Morán Geoconda Xiomara
Published: October 2024

La gimnasia es una disciplina deportiva caracterizada por su gama de movimientos llamativos y de gran dificulta. Dentro de esta disciplina se considera a la rondada como un elemento acrobático de dificultad media. Por lo mismo, el principal objetivo del presente estudio es realizar un análisis biomecánico de los ángulos de ejecución de la rondada en cada una de sus fases considerando la posibilidad de mejoras técnicas y prevención de lesiones. Para cumplir con el objetivo descrito se realizó una investigación de tipo cuasi experimental con enfoque descriptivo, la búsqueda teórica se centró en bases de datos fiables y buscadores académicos como: Dialnet, Scielo, Scopus, Redalyc, SienceDirect y Google Académico. Para agudizar el proceso de recolección de información se aplico operadores booleanos como “AND” y “OR” acompañado del operador de concatenación “+”. De la misma forma, el análisis biomecánico se desarrolló a través del uso del software Kinovea, siendo este el principal instrumento de análisis. Los resultados obtenidos son claros en cuanto a la descripción de una correcta ejecución de las fases del elemento acrobático mencionado, asimismo, se deja el presente estudio como base teórico-literaria para promover futuras investigaciones dentro del campo deportivo, destacando los factores biomecánicos como aspectos a considerar para la optimización del gesto técnico.
Systematic Literature Review on the Implementation of the Pesantren Muadalah Certificate Policy in Indonesia
Authors: Muzayana Iktafi
Published: October 2024

This research explores how Islamic boarding schools are implementing and responding to the modern education system introduced by the Government through the equalization policy (mu'ilah). Considering the vast amount of existing research, a review is necessary to categorize the literature, ensuring the information is clearly and easily understood. The paper applies the Systematic Literature Review (SLR) method, focusing on public policy implementation studies from 2019 to 2023. The SLR process includes defining Research Questions (R.Q.), setting Inclusion and Exclusion Criteria, and conducting Quality Assessments (QA). The findings reveal that the Mujadi diploma policy has been aligned with the Government's formal school diploma. Islamic boarding schools issuing Mujadi diplomas are referred to as Islamic Boarding Schools, specifically those that run Muilah Education Units (SPM). Based on both the supporting and inhibiting factors identified from various sources, the Mujadi policy has proven to be effective in its implementation within the Mujadi Islamic boarding schools.
Choosing science and mathematics programs in college: practical and psychological arbiters in career-pathing
Authors: Verdeflor Richard N.
Published: October 2024

The objective of this exploratory qualitative research is to investigate the practical and psychological factors influencing students’ decisions to pursue science and mathematics-based courses for their career paths. The study will focus on a sample size of 25 second-year students in Calbayog City who have chosen to continue with their chosen course after completing one year of study. To collect data, the study will use one-on-one interviews, a qualitative research method. This method will allow for a thorough investigation of the participants’ experiences, viewpoints, and motives. Through one-on-one interviews, the researchers are able to acquire a thorough understanding of the factors that influence students’ decision-making processes. The findings of this study will provide important insights into the practical and psychological factors that impact students’ selections in science and mathematics courses. This information can be utilized to improve career advising programs and educational systems, as well as to guide students who are exploring comparable career options.
technology-agnostic framework for designing assessments in the era of artificial intelligence
Authors: Curwood Jen Scott , Kelly Nick , Grace Kazjon , Lazarou Karly
Published: October 2024

There is an urgent need to understand and benefit from artificial intelligence within schools. However, government policies that focus on academic integrity and duty of care do not address how students can leverage AI to enhance their learning nor how teachers can intentionally design assessments to account for AI. The Australian Framework for Generative Artificial Intelligence in Schools suggests that assessments need to clearly state “how generative AI tools should or should not be used” while also permitting a “clear and unbiased evaluation of student ability”. This is a worthy aspiration, yet there are presently few tools and examples to guide teachers in creating assessments. This conceptual paper draws from the field of design to articulate a framework for developing assessments that focuses on AI dialogue and trace-augmented critical reflection.
The Qualifications of a High School Physics Teacher Have
Authors: Kotsis Konstantinos T.
Published: October 2024

This study critically examines at the requirements for physics teachers in secondary schools. This study intends to shed light on the topic and offer insightful information for educators, policy-makers, and other stakeholders in the field of education by examining the many abilities, know-how, and experiences that go into good physics instruction at the high school level. This essay will demonstrate the necessary credentials that high school physics teachers should have in order to successfully engage students, improve learning outcomes, and support the success of science education in secondary schools through a thorough analysis of current research, educational standards, and best practices. The study aims to provide light on this important subject in order to contribute to current debates and decision-making processes concerning the hiring, preparation, and advancement of high school physics instructors. The ultimate objective of this research is to enhance physics education for the benefit of both society and students.
ChatGPT as Teacher Assistant for Physics Teaching
Authors: Kotsis Konstantinos T.
Published: October 2024

This study explores the integration of ChatGPT as a teaching assistant in physics education, emphasizing its potential to transform traditional pedagogical approaches. ChatGPT facilitates interactive and inquiry-based learning grounded in constructivist learning theory, allowing students to engage actively in experiments and better grasp abstract concepts through hands-on activities. The AI's adaptive dialogue systems promote socio-constructivist learning by encouraging social interaction and personalized feedback, which is essential for addressing individual learning gaps and enhancing student engagement. ChatGPT's ability to simulate real-world physics problems and provide immediate feedback fosters experiential learning, making complex concepts more accessible and promoting critical thinking skills. By offering tailored interventions and adapting to individual learning paces, ChatGPT supports a personalized educational experience that caters to the unique needs of each student. This adaptability is particularly beneficial in physics education, where students often struggle with abstract concepts and require immediate clarification to progress effectively. The paper concludes that the synthesis of generative AI and pedagogy has the potential to reshape science education, fostering deeper understanding and curiosity among students. By leveraging innovative methodologies and augmented data, ChatGPT enriches teacher-student interactions, creating a comprehensive educational experience that promotes a culture of curiosity and exploration, thereby nurturing future scientists and engineers. Ultimately, the integration of ChatGPT into physics education offers a valuable opportunity to enhance student engagement and understanding of scientific concepts through interactive and personalized support.
The Mediating Role of Work Alienation in Person Job/Organisation/Supervisor/Group Fit and Turnover Intention
Authors: UGUR Burcu , KARACA Mustafa
Published: October 2024

Nowadays, with the increase in competition conditions, businesses are evolving towards a more complex structure. It is an undeniable fact that person-job fit, person-organisation fit, person-supervisor fit and person-group fit play an important role in maintaining the current employment and increasing the success of the organisation. In this study, it is aimed to reveal the effect of person-job fit, person-organisation fit, person-supervisor fit and person-group fit on turnover intention and to determine the mediating role of job alienation. For this purpose, quantitative research methods were selected from the research methods and a questionnaire form was used as a data collection tool.
KẾT QUẢ NGHIÊN CỨU TUYỂN CHỌN MẪU GIỐNG CÂY HƯƠNG NHU TRẮNG (OCIMUM GRATISSIMUM L.) CHO NĂNG SUẤT DƯỢC LIỆU VÀ HÀM LƯỢNG HOẠT CHẤT CAO
Authors: Hoàng Thị Sáu  , Đào Văn Châu  , Phạm Văn Cường
Published: October 2024

Tiến hành nghiên cứu 6 mẫu giống Hương nhu trắng HNT7; HNT8; HNT9; HNT14; HNT15 và HNT20 nhằm tuyển chọn được 2-3 mẫu giống cho năng suất dược liệu và hàm lượng hoạt chất cao. Kết quả nghiên cứu đã tuyển chọn được 3 mẫu giống có khă năng sinh trưởng, phát triển tốt, cho năng suất dược liệu và hoạt chất cao, ổn định nhất. qua các vụ chọn lọc gồm NHT8, NHT9, NHT20. Năng suất dược liệu tươi/ha/lứa cắt lần lượt là 10,65 tấn/ha; 9,83 tấn/ha; 11,67  tấn/ha; hàm lượng tinh dầu lần lượt là 2,39; 3,39; 2,11 % và hàm lượng eugenol lần lượt là 299,64; 300,28; 289,1 mg/ml.; năng suất tinh dầu đạt 66,20; 82,44; 66,59 lít/ha.
Acute Lymphoblastic Leukemia, Version 2.2024, NCCN Clinical Practice Guidelines in Oncology
Authors: Shah Bijal , Mattison Ryan J. , Abboud Ramzi , Abdelmessieh Peter , Aldoss Ibrahim , Burke Patrick W. , DeAngelo Daniel J. , Dinner Shira , Fathi Amir T. , Gauthier Jordan , Haddadin Michael , Jain Nitin , Jonas Brian , Kirby Suzanne , Liedtke Michaela , Litzow Mark , Logan Aaron , Long Meixiao , Luger Selina , Mangan James K. , Massaro Stephanie , May William , Oluwole Olalekan , Park Jae , Przespolewski Amanda , Rangaraju Sravanti , Saygin Caner , Schwartz Marc , Shami Paul , Tomlinson Benjamin , Webster Jonathan , Awotiwon Ajibola , Stehman Katie
Published: October 2024

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for acute lymphoblastic leukemia (ALL) provide recommendations for management of ALL, with a focus on the classification of ALL subtypes based on immunophenotype and cytogenetic/molecular markers; risk assessment and stratification for risk-adapted therapy; treatment strategies for Philadelphia chromosome (Ph)-positive and Ph-negative ALL for both adolescent and young adult and adult patients; and supportive care considerations. This selection from the NCCN Guidelines for ALL focuses on treatment recommendations for adults with newly diagnosed Ph-negative ALL based on current evidence.
Sympathetic Blockade for Pain Associated With Nonaxial Bone Lesions in Patients With Cancer: An Uncontrolled Cohort
Authors: Roldan Carlos J. , Ye Alice L. , Podgorski Edward , Song Jonathan , Chung Matthew , Huh Billy
Published: October 2024

Background: Cancer-related bone pain remains a prevalent and frequently incapacitating ailment. Although conventional approaches effectively alleviate pain in most individuals, a subset of patients may continue to experience intractable pain. Current recommendations for treating cancer-related bone pain include oral analgesics and multimodal adjuvants, radiation therapy, and, in selected cases, intrathecal therapy. Cancer-related bone pain is mediated by a proliferation of sensory and sympathetic fibers. Thus, we believe that this pain can be successfully managed with minimally invasive sympathetic blockade (SB). Methods: In a retrospective observational cohort, we reviewed patients who underwent single-shot SB for uncontrolled cancer-related bone pain despite receiving opiate analgesics and other interventions. We documented the Edmonton Symptom Assessment Scale (ESAS) ratings, the numeric rating scale (NRS) pain scores, and the morphine equivalent daily dose (MEDD) before and after SB. Results: The final cohort included 43 patients (median age, 58 years [range, 23–86 years]) with a history of bone pain experienced for a median of 6 months (IQR, 3–12 months). Comparing before and after the SB, patients had pain reduction –6 (IQR, –7 to –4; P<.001), reduction of ESAS scores of –17 (IQR, –23 to –3; P<.001), and reduction of MEDD –57 mg (95% CI, –79 to –34; P<.001). The treatment was well tolerated. Conclusions: Blockade of sympathetic afferent innervation is an effective and cost-effective modality that can be safely used to palliate intractable pain in patients with malignant bone pain.
Tailoring Escalation Adjuvant Therapy for Early-Stage Triple-Negative Breast Cancer in the CBCSG010 Clinical Trial Biomarker Analysis
Authors: Wu Wenya , Yang Yunsong , Yang Wentao , Pang Da , Liu Yunjiang , Sheng Yuan , Li Xinzheng , Yu Shiyou , Cao Yali , Jiang Guoqin , Jin Feng , Ma Binlin , Li Junjie , Shao Zhiming
Published: October 2024

Background: Triple-negative breast cancer (TNBC) is a highly heterogeneous disease. The CBCSG010 trial is a prospective and multicenter phase III clinical trial confirming that adding adjuvant capecitabine significantly improved the 5-year disease-free survival (DFS) rate in patients with TNBC by 5.9%. In this study, we attempted to identify the specific population that benefited from adjuvant therapy. Methods: In this retrospective exploratory analysis, we performed RNA sequencing of tumor tissues from patients with TNBC in the CBCSG010 clinical trial. A single-sample gene set enrichment analysis algorithm and survival analysis were performed to characterize the intrinsic molecular features of the TNBC microenvironment and assess the associations between immune-related gene expression levels or immune cell counts with capecitabine treatment efficacy. Additionally, we performed immunohistochemical staining of 2 markers, PD-L1 and CD8, and hematoxylin-eosin staining of stromal tumor–infiltrating lymphocytes (sTILs) on formalin-fixed, paraffin-embedded specimens to validate findings from bioinformatics analyses. Results: We found that patients with TNBC with high immune-infiltration treated with capecitabine were more likely to have a better prognosis. We used a cutoff of ≥25 combined positive score (CPS) of PD-L1, ≥10% positive sTILs, and ≥10% positive cells of CD8 to define the “immune-hot” patients. Among immune-hot patients, Kaplan-Meier curves showed that 5-year DFS rates were 96.9% and 79.4% in the capecitabine and control groups, respectively (hazard ratio, 0.13; 95% CI, 0.03–0.52; P=.049 in favor of capecitabine). In the capecitabine group, the 5-year DFS rate was higher for immune-hot patients than for immune-cold patients (96.9% vs 76.4%; hazard ratio, 0.11; 95% CI, 0.04–0.29; P=.028). Conclusions: Our study suggested that immune-hot patients with TNBC are more likely to benefit from adjuvant capecitabine, and that combining immunotherapy with chemotherapy may be expected to be more effective in immune-hot patients.
The Role of CAR T-Cell Therapy in Relapsed/Refractory Adult B-ALL
Authors: Othman Tamer , Logan Aaron C. , Muffly Lori , Leonard Jessica , Park Jae , Shah Bijal , Aldoss Ibrahim
Published: October 2024

CAR T-cell therapy is a recent therapeutic advancement that has transformed the management of relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL). To date, there are 2 FDA-approved CAR-T products for R/R B-ALL: tisagenlecleucel in patients aged <26 years and brexucabtagene autoleucel in those aged ≥18 years. This review summarizes the pivotal clinical trials that led to FDA approval of these 2 products and highlight emerging data addressing key questions pertinent to CAR-T utilization in the rapidly evolving landscape of R/R ALL management. These include optimal sequencing of CAR-T among other novel immunotherapeutic agents, the role of consolidation and maintenance following CAR-T, novel CAR-T constructs currently under clinical development, and strategies to optimize use of commercially available CAR-T products to improve patient outcomes.
Comparing economic outcomes and reimbursement trends between primary total knee arthroplasty and unicompartmental knee arthroplasty
Authors: Wu Scott A , Plantz Mark A , Gerlach Erik B , Swiatek Peter R , Hardt Kevin D
Published: October 2024

Background

Economic outcomes are of paramount importance in the American healthcare market as healthcare costs continue to rise. The Centers of Medicare and Medicaid Services (CMS) introduced the relative value unit (RVU) in 1992 to operationalize economic outcomes of healthcare interactions and procedures available to patients. The purpose of this study is to compare the RVU and dollar compensations, operative times, and compensation rates of unicompartmental knee arthroplasty (UKA) vs total knee arthroplasty (TKA) in the context of procedural and perioperative care requirements.

Methods

The National Surgical Quality Improvement Program database was used to query all UKAs and TKAs (current procedural terminology codes 27446 and 27447, respectively) performed between January 1, 2015 and December 31, 2017. 162,239 cases were analyzed: 157,107 TKAs and 5,132 UKAs. For all economic and medical variables, unpaired t-test and Pearson’s chi-squared test were used to compare continuous and categorical data, respectively.

Results

RVUs for UKAs and TKAs were 17.48 and 20.72, respectively. The mean operative time for UKAs was 83.80 ± 30.13 minutes and 89.43 ± 31.88 minutes for TKAs (p < 0.001). The mean RVU/min for UKAs and TKAs were 0.23 ± 0.08 and 0.26 ± 0.09, respectively (p < 0.001). Dollar reimbursements for UKA vs TKA were as follows: per minute ($8.46 vs $9.36) and per case ($630.85 vs $747.78). TKAs were associated with longer hospital length of stay (2.52 ± 3.20 vs. 1.43 ± 2.72 days; p < 0.001), quicker onset of deep wound infection (18.46 ± 7.24 vs. 21.43 ± 5.19 days; p < 0.001), and higher rates of 30-day unplanned hospital readmission (3.07% vs. 1.87%; p < 0.001).

Conclusion

The study found the contemporary RVU reimbursement model adequately accounts for increased operative time and perioperative care demands associated with TKA compared to UKA, as RVU and dollar compensation rates per case and per minute were significantly greater for TKAs.
Презумпция необходимой зрелости сознательно-волевой сферы физического лица
Authors: Veliyev Ruslan
Published: October 2024

The article examines the types of legal presumptions, provides an analytical review of the literature, as well as the opinions of civil scientists on the topic under study. Based on the theoretical analysis, a definition of the concept of civil capacity of an individual as a presumption of the necessary maturity of the conscious-volitional sphere of an individual has been developed. It is stated that, in the presence of legal facts indicating a negative impact on the conscious-volitional sphere of an individual, such a presumption can be refuted. It is concluded that the refutation of the presumption of the necessary maturity of the conscious-volitional sphere of an individual is the restriction of the civil capacity of an individual, and the legal facts are the statutory grounds for limiting the capacity. The given author's definition allows us to clarify the legal essence and features of the legal capacity of an individual and its limitations, which have theoretical and practical significance in legal science. Keywords: presumption, refutation of presumption, civil law, family law, objective law, legal personality, legal capacity, legal capacity, limitation of legal capacity, legal capacity, legal capacity to commit a delict, social maturity, conscious-volitional sphere, reasonableness, conscientious behavior, legal fact, individual, guardian, trustee.
Konstitusiyaya dəyişikliyə zərurət varmı: Azərbaycanda informasiya sahəsində hüquq və azadlıqlara dair normalarda ziddiyyətlər
Authors: Rzayeva Gulnaz
Published: October 2024

The Constitution of the Republic of Azerbaijan forms the basis of the national legislative system. As in all areas of law, the guiding provisions and preliminary beginnings for the right to information are defined in the Constitution. However, the changes in the forms of realization of rights and freedoms in the field of information, arising from the demands of the modern era, make it necessary to reconsider many constitutional norms. In the article we have presented, the following articles of the Constitution of the Republic of Azerbaijan will be analyzed and suggestions and recommendations will be presented: freedom of information (Article 50 of the Constitution of the Republic of Azerbaijan); freedom of thought and speech (Article 47 of the Constitution of the Republic of Azerbaijan); guarantee of human and civil rights and freedoms (Article 71 of the Constitution of the Republic of Azerbaijan). Keywords: Constitution of the Republic of Azerbaijan, freedom of information, freedom of expression, restrictions, legitimate interests, proportionality.
A mindenkinek szent város
Authors: Kovács Viktor
Published: October 2024

Kőszeghy Miklós egyetemi tanár, a Pázmány Péter Katolikus Egyetem Ókortörténeti tanszékének, és az Evangélikus Hittudományi Egyetem Ószövetségi Teológia Tanszékének oktatója átfogó művet publikált Jeruzsálem, Egy rejtőzködő város története címmel. A könyv a nagyjából meghatározható alapítástól rajzolja meg a város történetét Kr.u. 70-ig, a heródesi templom és a város (nem első és nem is utolsó) pusztulásáig. Bár ezen időintervallum is igen jelentős (nagyjából ezerötszáz-ezerhatszáz év), de a szerző mégsem elégszik meg ennyivel, és a kötet végén - röviden - kitekint egészen Palesztina brit protektorátusi idejéig, érintve pl. a keresztes hadjáratok időszakát, illetve az oszmán birodalmi kort is.
A Comprehensive Security Risk Assesment Framework SRAF_IoV for Internet of Vehicles.
Authors: Memon Nisar , Memon Shahzad , Khoumbati Khalil , Memon Mudasir Ahmed
Published: October 2024

The advancement in digital world have led to the development of smart vehicles that connect to the Internet of Vehicles (IoV) Infrastructure. These smart vehicle also connects and communicate with other vehicles, and their connected components. Once connected, they can share information such as speed, direction, and distance between vehicles.IoV enhances traffic infrastructure by reducing congestion and incidents, ultimately improving  road safety within highways and metropolitan cities. However, when smart vehicles use IoV to share data through vehicle-to-vehicle (V2V), Vehicle to Infrastructure (V2I), and Vehicle to everything (V2X) they also introduce security risks and vulnerabilities to the IoV Infrastructure. Malicious actors can exploit these vulnerabilities to alter data within the connected units of IoV infrastructure, such as electronic control units, onboard units, control networks, and sensors. Securing data within the IoV ecosystem is crucial to prevent malicious activity that could compromise confidentiality, integrity, and availability.
In this study, a security risk assessment framework for IoV (SRAF-IoV) has been developed to identify vulnerabilities within the IoV network.  SRAF-IoV that assesses security risks in connected vehicles. It evaluates vulnerabilities and assigns a risk level based on different communication channels (V2V, V2I, and V2X). The proposed framework was tested against various cyber-attacks to determine risk levels associated with different attack types  (low, medium, high, and critical). The performance of SRAF-IoV was then compared to existing frameworks. By comprehensively identifying potential risks,  SRAF-IoV was then compared to existing frameworks. By comprehensively identifying potential risks, SRAF-IoV can push the smart vehicle industry to make critical security decisions during the development of smart vehicles.
Microbial fuel cells: A potent and sustainable solution for heavy metal removal
Authors: Akagunduz Dilan , Aydin Ozlem , Tuncay Ebru , Bermek Hakan
Published: October 2024

The global water pollution problem is becoming increasingly crucial. One of the major contributors to water pollution is the presence of heavy metals. Heavy metals pose significant threat to both humans and all ecosystems. Various factors influence the removal of heavy metals from wastewater, including pH, temperature, natural organic matter (NOM), and ionic strength, which vary based on the chemical properties of the pollutants. More effective and modern approaches receive attention and extensively researched to substitute traditional methods such as adsorption, membrane filtration, and chemical-based separation. Among these methods, Microbial fuel cells (MFCs) are particularly intriguing. This review article focuses on MFCs and their potential applications in various fields, including clean water production. MFCs represent an innovative technology that not only generates electricity, but also demonstrates significant potential for heavy metal removal from wastewater. Cathodic chamber of MFCs effectively reduces heavy metals, while organic substrates act as carbon and electron donors in the anodic chamber. Through various mechanisms, including direct and indirect metal reduction, biofilm formation (metal sequestering), electron shuttling, and synergistic interactions among microbial communities, microorganisms exhibit remarkable efficiency in removing metals. Studies showed that dual- and single-chamber MFCs could efficiently remove a range of heavy metals, including chromium, cobalt, copper, vanadium, mercury, gold, selenium, lead, magnesium, manganese, zinc, and sodium, while simultaneously generating electricity, achieving high removal efficiencies ranging from 25% to 99.95%. This range of efficiency varies depending on the specific contaminant being targeted, the concentration of the contaminant, as well as the operating conditions such as pH and temperature. Moreover, MFCs demonstrated a wide range of power outputs, typically ranging from 0.15 W/m² to 6.58 W/m², depending on the specific configuration and conditions. These findings underscore the potential of MFCs as a sustainable and efficient approach for both wastewater treatment and energy generation.
Marcadores de riesgo en pacientes diabéticos con infección por SARS-CoV-2
Authors: Trovero Bianca , Villalba Silvia María , Collino César Juan Gerardo , Baroni María Verónica , Luján Pablo Rodrigo
Published: October 2024

Introducción: la diabetes mellitus es un factor de riesgo para el desarrollo de la infección por coronavirus causante del síndrome respiratorio agudo severo 2 (SARS-CoV-2). Objetivos: analizar parámetros de laboratorio que puedan ser considerados como factores de riesgo para una evolución desfavorable de la infección y de esta manera, lograr un manejo adecuado de la enfermedad para obtener resultados favorables en su evolución. Materiales y métodos: se incluyeron 131 pacientes diabéticos con diagnóstico de COVID-19 que fueron admitidos para internación. Se los agrupó en relación con otras comorbilidades y de acuerdo con la severidad de la infección. Se extrajeron los datos del laboratorio de ingreso de los siguientes parámetros: recuento de glóbulos blancos, neutrófilos y linfocitos; glucemia; ferritina; dímero D; proteína C reactiva; procalcitonina; presión parcial de oxígeno y hemoglobina glicada. Para el análisis, se realizó una prueba t de Student y un análisis de la varianza, al igual que uno de componentes principales para evaluar la severidad de la infección y comorbilidades, con las diferentes variables. Resultados: en la enfermedad severa, las concentraciones de ferritina, proteína C reactiva y procalcitonina fueron significativamente mayores que en la enfermedad moderada (p < 0,05; p < 0,05; p < 0,01, respectivamente); no así para el resto de los analitos. Un recuento de linfocitos más elevado se asoció al desarrollo de enfermedad moderada. Conclusiones: los pacientes diabéticos que presentan recuentos de linfocitos más bajos, con concentraciones de ferritina y proteína C reactiva más elevadas tienen mayor riesgo de desarrollar enfermedad severa, independientemente del control glucémico.
Sobre un caso de amiloidosis primaria (AL) asociada a IgM con relación kappa/lambda dentro del rango de referencia.
Authors: Nievez Luciano David , Alcat Nahuel , Cioffi Antonela
Published: October 2024

Introducción: Las amiloidosis son un grupo de enfermedades que se manifiestan como consecuencia del plegamiento incorrecto y la agregación localizada o sistémica de proteínas autólogas que se depositan en los tejidos en forma de fibrillas amiloides. La amiloidosis primaria o de cadenas livianas libres (AL) es la forma más común de amiloidosis sistémica, con una incidencia anual de 0,9 nuevos casos por 100000 habitantes. Materiales y métodos:  Se presenta un caso clínico de un paciente diagnosticado con AL asociada a IgM Lambda durante su estadía en el Hospital Interzonal General de Agudos Evita de Lanús. Resultados: Paciente de sexo masculino de 47 años de edad con diagnóstico primario de insuficiencia cardíaca. Durante la internación, se  observó la presencia de un depósito de material eosinófilo amorfo rojo congo positivo, en el fragmento de tejido fibroconectivo remitido a anatomía patológica, por lo cual se confirmó el diagnóstico de amiloidosis con compromiso renal y cardiológico.  No se obtuvieron resultados concluyentes en el análisis del proteinograma electroforético en suero y la cuantificación de las cadenas livianas libres.  Luego, se obtuvo mediante el estudio de inmunofijación en suero, la presencia de un componente monoclonal de isotipo IgM Lambda, permitiendo el diagnóstico diferencial de AL. Conclusión: En este paciente el uso del algoritmo: proteinograma electroforética en suero + inmunofijación en suero + cadenas Livianas Libres en suero permitió arribar a un correcto resultado.
Detección temprana y eficiente de variantes Delta y Ómicron deS ARS- Cov- 2 COVID-19 mediante tamizaje por RT-qPCR
Authors: Juri Ayub Maximiliano , Manzur María Jimena , Campos Ludmila Estefanía , Arias José Luis , Leporati Marianela
Published: October 2024

Introducción: Durante la pandemia de enfermedad por coronavirus de 2019 (COVID-19, por sus siglas en inglés), el surgimiento de las llamadas variantes de preocupación ha sido un problema recurrente. La secuenciación genómica es la herramienta de referencia para la identificación de nuevas variantes, así como para detectar la circulación de las ya conocidas. Sin embargo, la capacidad del sistema de vigilancia genómica es limitada y se requieren estrategias de tamizaje previo para la selección de muestras. Objetivos: Diseñar, validar y aplicar estrategias de transcripción reversa acoplada a reacción en cadena de la polimerasa cuantitativa (RTqPCR, por sus siglas en inglés) para el tamizaje de variantes delta, ómicron y la emergencia de posibles nuevas variantes. Materiales y Métodos: Se diseñaron oligonucleótidos específicos (primers y sondas) que permiten discriminar entre las diferentes variantes de SARS-Cov-2, al hibridar con regiones correspondientes a deleciones específicas. Se emplearon ensayos de amplificación y melting de sondas fluorescentes y se validaron con muestras de diferentes variantes de preocupación. Resultados: Los ensayos permitieron identificar variantes de preocupación de manera rápida y eficiente, empleando metodologías estándar en laboratorios de diagnóstico molecular. La asignación de variantes con este método coincidió completamente con los datos provenientes de la secuenciación. Conclusiones: Los protocolos validados en este trabajo posibilitaron la detección temprana de variantes delta y ómicron en la provincia de San Luis, así como en otras jurisdicciones donde se transfirió la metodología.
Estabilidad de coronavirus y virus herpes simplex tipo 1 en barbijos y batas quirúrgicas que componen el EPP
Authors: Ayala-Peña Victoria Belén , Scolaro Luis Alberto , Alvarez Vera Alejandra , Lassalle Verónica Leticia
Published: October 2024

Introducción: Durante la actual pandemia de COVID-19 han surgido muchas controversias e interrogantes respecto de la persistencia de la actividad viral en distintas superficies. Para el área de salud, ha sido un gran desafío lograr optimizar los usos de equipos de protección personal (EPP), teniendo en cuenta la incertidumbre acerca de la estabilidad de las partículas virales sobre distintas superficies. Objetivos: Analizar la estabilidad viral en barbijos quirúrgicos y batas descartables. Materiales y métodos: Se emplearon barbijos quirúrgicos tricapa comerciales y batas aprobados por ANMAT a los cuales se los inoculó artificialmente con cantidades definidas de virus herpes simplex tipo I (HSV-1) y de coronavirus bovino (BCoV) en condiciones ambientales estrictamente establecidas, o se los expuso a pacientes COVID positivos para luego evaluar la infectividad viral residual o remanente mediante la técnica de UFP (unidad formadora de placa) y por la aparición de ECP (efecto citopático) en cultivos celulares infectados con el virus residual. Resultados: El tiempo de inactivación fue dependiente de la dosis infectiva inicial; para las dosis máximas estudiadas, los virus inoculados artificialmente permanecen viables hasta 72 horas, sin embargo, en la bata expuesta a pacientes COVID positivo, no se pudo recuperar la actividad viral luego de las 16 horas. Conclusiones: El tiempo de inactivación viral depende de la dosis infectiva inicial bajo las mismas condiciones ambientales. Mientras más alta es la dosis infectiva, más tiempo tardará en inactivarse el inóculo. Con dosis superiores a las esperadas naturalmente, el tiempo de inactivación de la actividad viral es de 72 horas.
Recomendaciones para el uso de biomarcadores en el paciente con COVID-19. Segunda parte
Authors: Castro Marcela Adriana , López María Alejandra , Jacquier Graciela Beatriz
Published: October 2024

Los daños que produce el virus SARS-CoV-2 en diferentes órganos del cuerpo humano (corazón, pulmón, riñón) pueden provocar complicaciones severas, que en el laboratorio clínico es posible evidenciar con el uso de biomarcadores. La presente revisión bibliográfica busca acercar a los bioquímicos de los laboratorios de Urgencias una actualización sobre las características, métodos de detección y uso adecuado de dos biomarcadores, troponina y péptidos natriuréticos, que permiten poner de manifiesto la injuria del miocardio en el diagnóstico y seguimiento de los pacientes que cursan la enfermedad COVID-19.
Primera guía de prácticas del laboratorio clínico en el estudio de las proteínas séricas a partir del proteinograma electroforético.
Authors: FERNANDEZ DIEGO JAVIER
Published: October 2024

Introducción: El laboratorio clínico de proteínas es uno de los pilares para la caracterización, el diagnóstico y el monitoreo de diversas patologías. Sin embargo, ante la heterogeneidad observada tanto en las metodologías utilizadas como en la confección del informe de los estudios proteicos en la encuesta realizada durante los años 2018-2019 en nuestro país, surge, desde el Foro de Proteínas, la necesidad de redactar el primer consenso sobre prácticas de laboratorio de proteínas. Objetivo: Presentar la primera guía de prácticas del laboratorio clínico en el estudio de las proteínas séricas a partir del proteinograma electroforético. Materiales y Métodos: El Foro de Proteínas, con sede en La Asociación Bioquímica Argentina, generó un ámbito de discusión, donde los profesionales especialistas en el área de Proteínas nos reunimos periódicamente para consensuar criterios que puedan ser utilizados como herramientas en la transmisión de resultados clínicamente útiles. Resultados: La presente guía recopila consensos sobre la etapa pre-analítica, analítica y post-analítica, brindando información valiosa sobre el tipo de muestra, interferencias, metodologías disponibles, análisis e informe de resultados. Conclusiones: Se pudo desarrollar mediante el consenso profesional la primera guía nacional para la unificación de criterios tanto metodológicos como de presentación de resultados.
La libertad autoritaria. Un diálogo con Pierre Dardot
Authors: Villavicencio Susana , Dardot Pierre
Published: October 2024

Surgido como un diálogo en torno a las implicancias de un retorno de las políticas neoliberales en Argentina, el texto recorre dimensiones del autoritarismo en el marco de democracias electorales. Se confrontan experiencias de autoritarismo en países como Chile de Pinochet, el gobierno de Menem o el actual de Milei en Argentina, indagando sobre la singularidad del proceso actual, los cambios de época, las diferencias entre la libertad y el “libertarianismo”, el impacto de las tecnologías de la comunicación y los efectos de la mundialización en la política y la economía. Palabras clave: Autoritarismo, libertarianismo, democracia, subjetivación política Authoritarian freedom: A Dialogue with Pierre DardotAbstractDeveloping as a dialogue around the implications of a return to neoliberal policies in Argentina, the text covers dimensions of authoritarianism in the framework of electoral democracies. Experiences of authoritarianism in countries such as Pinochet's Chile, Menem's government or Milei's current government in Argentina are confronted, inquiring about the singularity of the current process, the changes of era, the differences between freedom and "libertarianism", the impact of communication technologies and the effects of globalization on politics and the economy. Keywords: Authoritarianism, libertarianism, democracy, political subjectivation ARK CAICYT: https://id.caicyt.gov.ar/ark:/s16668979/t9pallo6w
Creación, significado y usos del concepto autoritarismo burocrático. Notas para pensar innovaciones teóricas pasadas y presentes
Authors: Lesgart Cecilia
Published: October 2024

El concepto autoritarismo ha regresado a los debates académicos en un tiempo de corrosión de la democracia representativa y del orden internacional liberal. Su retorno se produce después de décadas de haber sido desplazado por el concepto de democracia, usado teóricamente como su opuesto contrastante y como condensador de las aspiraciones proscriptas por las dictaduras cívico-militares. Al mismo tiempo, los conceptos que permitían nombrar el mundo político se encuentran en crisis, y el de autoritarismo ha transformado sus usos y significados con respecto al pasado reciente. El objetivo de este escrito es reconstruir la historia de un concepto particular, el de autoritarismo burocrático, creado por Guillermo O`Donnell para analizar la construcción de un tipo de Estado y de régimen político que emergió con el golpe de estado de 1966 en Argentina. Su reconstrucción contribuirá a mostrar la historia de un concepto nacido dentro de la Ciencia Política con intenciones analíticas que renovó la manera de abordar las formas políticas devenidas de golpes cívico-militares. Asimismo, dejará un terreno preparado para compararlo con el modo amplio con el que actualmente se usa el término al interior de la disciplina, no ligado a los golpes de estado y utilizado para describir estilos de gobierno.    Palabras clave: Autoritarismo, autoritarismo burocrático, régimen político, estilos de gobierno Creation, meaning and uses of bureaucratic authoritarianism. Notes for thinking about past and present innovationsAbstractThe concept of authoritarianism has returned to academic debates at a time of corrosion of representative democracy and the liberal international order. Its return comes after decades of being displaced by the concept of liberal and representative democracy, used theoretically as a contrasting opposite and as a condenser of the aspirations proscribed by civil-military dictatorships. At the same time, the concepts that made it possible to name the political arena are in crisis, and the concept of authoritarianism has disassembled the uses and meanings with respect to the recent past. The aim of this paper is to reconstruct the history of a particular concept, that of Bureaucratic-Authoritarianism, created by Guillermo O`Donnell to analyze the construction of a type of state and a political regimen that emerged with the 1966 coup d’état in Argentina. Its reconstruction will also leave a ground for comparison with the broad way in which the term is currently used within the discipline, not linked to coups d`etat, and used to describe leadership styles of government. Keywords: Authoritarianism, Bureaucratic Authoritarianism, political regimen, style of government ARK CAICYT: https://id.caicyt.gov.ar/ark:/s16668979/dtb8oax2g
Internacionalización del capital y crisis del Estado en la teoría de Nicos Poulantzas: el concepto de estatismo autoritario
Authors: Gorriti Jacinta
Published: October 2024

Este artículo analiza el concepto de estatismo autoritario que Nicos Poulantzas acuña en los años setenta para definir la nueva forma democrática del Estado capitalista que surge con el proceso de internacionalización de las relaciones de producción y la división social del trabajo. La particularidad de esta noción es que articula, en vez de oponer tajantemente, democracia y autoritarismo, al mostrar que la dominación política exige en esta fase una modulación cada vez más autoritaria del poder. La hipótesis que se propone es que el estatismo autoritario no solo describe un fenómeno ligado a la consolidación temprana del neoliberalismo en las formaciones sociales europeas, sino que formula “en estado práctico” un problema político que tiene repercusiones en la coyuntura nacional y mundial actual. En este sentido, se sugiere que las elaboraciones de Poulantzas brindan algunas claves para entender la crisis de la democracia que atraviesan actualmente las sociedades latinoamericanas.Palabras clave: crisis de los regímenes democráticos, materialidad del Estado, autoritarismo, internacionalización del capital Internationalization of Capital and Crisis of the State in Nicos Poulantzas’ Theory: The Concept of Authoritarian StatismAbstractThis article analyzes the concept of authoritarian statism coined by Nicos Poulantzas in the 1970s to define the new democratic form of the capitalist state that arises with the internationalization of the relations of production and the social division of labor. The particularity of this notion lies in its articulation, rather than stark opposition, of democracy and authoritarianism, by showing that political domination in this phase demands an increasingly authoritarian modulation of power. The hypothesis proposed is that authoritarian statism not only describes a phenomenon linked to the early consolidation of neoliberalism in European social formations, but also formulates, “in a practical state”, a political problem with repercussions in the current national and global context. In this sense, it is suggested that Poulantzas' elaborations provide some keys to understand the crisis of democracy currently experienced by Latin American societies.Key Words: Crisis of democratic regimes, State materiality, Authoritarianism, Internationalization of Capital ARK CAICYT: https://id.caicyt.gov.ar/ark:/s16668979/xkrjnnguo