bluuebunny/crossref_metadata_2025 huggingface dataset:
Deficiency of LRRC4 Accelerates Experimental Autoimmune Encephalomyelitis by Disrupting Th1/Treg Cell Balance
Authors: Zhang Yan , Li Di , Zeng Qiuming , Feng Jianbo , Fu Haijuan , Luo Zhaohui , Xiao Bo , Yang Huan , Wu Minghua
Published: December 2019

Background Leucine rich repeat containing 4 (LRRC4), also known as netrin-G ligand-2 (NGL-2), belongs to the superfamily of LRR proteins and serves as a receptor for netrin-G2. LRRC4 regulates the formation of excitatory synapses and promotes axon differentiation. Mutations in LRRC4 occur in Autism Spectrum Disorder (ASD) and intellectual disability. Multiple sclerosis (MS) is a chronic autoimmune disease characterized by immune-mediated demyelination and neurodegeneration of the central nervous system (CNS). Here, we investigated the role of LRRC4 in the pathological process of experimental autoimmune encephalomyelitis (EAE), a widely used mouse model of MS.Methods LRRC4 was detected in the CNS of EAE mice by the use of real-time PCR and western blotting. LRRC4 -/- mice were created and immunized with myelin oligodendrocyte glycoprotein peptide (MOG) 35–55 . Pathological changes in spinal cords of LRRC4 -/- and WT mice 15 days after immunization were examined by using hematoxylin and eosin (H&E), Luxol Fast Blue (LFB) staining and immunohistochemistry. The number of Th1/Th2/Th17/Treg cells in spleens and blood were measured with flow cytometry. Differential gene expression in the spinal cords from WT and LRRC4 -/- mice was analyzed by using RNA sequencing (RNA-seq). Adeno-associated virus (AAV) vectors were used to overexpress LRRC4 (AAV-LRRC4) and were injected into EAE mice to assess the therapeutic effect of AAV-LRRC4 ectopic expression on EAE.Results We discovered that the level of LRRC4 decreases in the spinal cords of the EAE mice. Deletion of LRRC4 accelerates infiltration of leukocytes into the spinal cords and disease exacerbation in vivo. We further showed that LRRC4 deletion disrupts the balance between Th1 cells and Treg cells and causes a shift toward Th1 cells and that the disrupted balance may be attributed to up-regulation of IL-6, IFN-γ and down-regulation of TNF-α in EAE mice. At a mechanistic level, we found that deficiency of LRRC4 induces elevated NF-κB p65 expression and does so by up-regulating Rab7b, while ectopic expression of LRRC4 alleviates the clinical symptoms of EAE mice and protects the CNS from immune damages.Conclusions We establish a critical role of LRRC4 in the progression of EAE and provide novel mechanistic insights into EAE development. Our findings also suggest that LRRC4 may be used as a potential target for therapeutic treatment of MS.
First epidemiological survey of Angiostrongylus vasorum in domestic dogs from Spain
Authors: Carretón Elena , Morchón Rodrigo , Falcón-Cordón Yaiza , Matos Jorge , Costa-Rodríguez Nieves , Montoya-Alonso José ALberto
Published: December 2019

Background: Angiostrongylus vasorum is the causative agent of canine angiostrongylosis, a disease that mainly affects domestic dogs and others wild carnivores. In Europe, the number of infected individuals is increasing, being located in central and southern countries. In Spain, several studies have reported high prevalence of A. vasorum in wild animals. However, there are no studies that address the current situation of the disease or its distribution in domestic dogs, and complaints from veterinary personnel are very limited. Taking into account these facts, the objective of the present study was to evaluate the prevalence of A. vasorum in different areas of Spain.Methods: Between November 2018 and October 2019, blood was sampled from a total of 2024 domestic dogs from 6 zones of Spain with climatologies that favour the establishment of the disease, where all dogs included in the study lived outdoors or had regular access to areas with vegetation and none had traveled outside the study area of ​​interest in the past year. Details about their gender and age were collected. All dogs were tested for the presence of A. vasorum circulating antigens using AngioDetectTM. Results: The prevalence of canine angiostrongylosis in the studied areas of Spain was 1.73%. No differences were found between males and females but by age, significant differences were found between dogs <1 years and the rest of three groups of age. By eco-epidemiological areas, the highest prevalences were obtained in the north and northwest of Spain and the lowest was described in the central area.Conclusions: Our data suggest that the disease is present in Spain in domestic dogs where previously infected wild animals existed or where climatic conditions are favourable for the establishment of the disease.
Effects of hyperoxia on retinal autophagy in a mouse model of retinopathy of prematurity
Authors: Wang Jie , Du Ergang , Zheng Yunliang
Published: December 2019

Purpose To evaluate the autophagy activation of retina in an oxygen-induced retinopathy of prematurity (ROP) mouse model. Methods C57BL/6 mice were exposed to 75 ± 0.5% oxygen from P7 to P12, after which they were brought into room air and raised to P17. Mice underwent fluorescein angiography of the retinal vasculature on P17. The thickness and ultrastructural of retina was observed on P17. The expression of autophagy in the retina tissue was assessed by Quantitative real-time polymerase chain reaction and Western blot analysis. Results The neovascularization was significantly higher in the oxygen-induced mice. The retinal thickness of the oxygen-exposed group was higher than that of the control group on P17. The autophagosomes in retina of ROP mouse were observed. During the hyperoxia stage (from P8 to P13), the mRNA levels of Beclin1 (mammalian Atg6), Uncoordinated-51 like kinase 1 (ULK1), and Autophagy 5 (Atg5) were increased. At the relative hypoxia stage (raised in room air from P14 to P17), the expression of Beclin1, ULK1, and Atg5 mRNA levels was downregulated in retinas of ROP mice compare to the controls. Over time, the protein expression of Beclin-1, ULK1, and Bcl-2-associated X protein (Bax) was upregulated, but the protein expression of B-cell lymphoma 2 (Bcl-2) was downregulated. Conclusions Hyperoxia and relative hypoxia not only cause retinal neovascularization, but also change the autophagy markers in the retina of newborn mice.
The Free Flap Based on a Single Proximal Perforator of Radial Artery: the Ultrasonography Study and Clinical Applications in Reconstruction of Digital Defect
Authors: Wu Guangzhi , Zhang Zhan , Zhang Fan , Zhang Yiqun , Cui Shusen , Yu Wei
Published: December 2019

Background: To locate the anastomosable constant perforator of radial artery on the proximal forarm using ultrasonography, and describe the application of free radial artery flap based on a single proximal perforator in the reconstruction of digital soft tissue defects. Methods: In 20 forarms (10 right and 10 left) from 10 volunteers, the perforators in the proximal half of forarm from radial artery were visualized by ultrasonography. Then the free radial artery perforator flaps based on the single perforator were used for reconstruction of small digital soft tissue defects in 4 cases between October 2017 and May 2018. Results: Of the 20 forarms, anastomosable perforator was constantly detected from the radial artery in the proximal half of forarm. The diameter of the perforator was 0.7±0.1 mm, the pedicle length is 12±3 mm by ultrasonography. Ther location of the perforator is far from elbow crease 8.8±1.4 cm, and the relative distance of the perforator location from elbow crease to wrist crease is 37.2% ± 4.8%. In clinical cases, all the flaps were complete survival. Flap size ranged from 3.5 to 6.5 cm in length and 2.3 to 3.0 cm in width. Donor sites of forearm were closed primarily in all cases. During a mean period of 12 months (8-14 months) follow-up, there were satisfactory results of digital function and cosmesis,and no functional impairments at the donor sites. Conclusions: There is an anastomosable perforator consistent located on the radial artery in the proximal half of forarm. The free radial artery small flap based on this single perforator provides acceptable functional and cosmetic outcomes for the reconsturction of digital soft tissue defects . With the preservation of the main vessel (radial artery) of forearm, this flap provides another reliable option for handsurgery surgeon to reconstruct small digital defects.
Quantizing photosynthetic performance of phytoplankton using photosynthesis-irradiance response models
Authors: Yang Xiaolong , Liu Lihua , Yin Zhikai , Wang Xingyu , Wang Shoubing , Ye Zipiao
Published: December 2019

Background: Clarifying the relationship between photosynthesis and irradiance and accurately quantizing photosynthetic performance are of importance to calculate the productivity of phytoplankton, whether in aquatic ecosystems modelling or obtaining more economical production.Results: The photosynthetic performance of seven phytoplankton species was characterized by four typical photosynthesis-irradiance (P-I) response models. However, the differences were found between the returned values to photosynthetic characteristics by different P-I models. The saturation irradiance (Isat) was distinctly underestimated by model 1, and the maximum net photosynthetic rate (Pnmax) was quite distinct from its measured values, due to the asymptotic function of the model. Models 2 and 3 lost some foundation to photosynthetic mechanisms, that the returned Isat showed significant differences with the measured data. Model 4 for higher plants could reproduce the irradiance response trends of photosynthesis well for all phytoplankton species and obtained close values to the measured data, but the fitting curves exhibited some slight deviations under the low intensity of irradiance. Different phytoplankton species showed differences in photosynthetic productivity and characteristics. P. subcordiformis showed larger intrinsic quantum yield (α) and lower Isat and light compensation point (Ic) than D. salina or I. galbana. Microcystis sp., especially M. aeruginosa with the largest Pnmax and α among freshwater phytoplankton strains, exhibited more efficient light use efficiency than two species of green algae.Conclusions: The present work will be useful both to describe the behavior of different phytoplankton in a quantitative way as well as to evaluate the flexibility and reusability of P-I models. Meanwhile we believe this research could provide important insight into the structure changes of phytoplankton communities in the aquatic ecosystems.
Proportion and characteristics of patients with Type 2 diabetes mellitus initiating basal insulin therapy using a basal-bolus regimen
Authors: Zhang Puhong , Zhang Heng , Zhu Dongshan , Li Xian , Ji Jiachao , Chen Minyuan , Wang Du , Ji Linong
Published: December 2019

Background: To explore the proportion and characteristics of patients with Type 2 diabetes mellitus (T2DM) uncontrolled by oral antidiabetic drugs (OADs) who initiated basal insulin (BI) therapy using a basal-bolus regimen. Methods: This multicenter, observational, prospective study included a representative sample of 18,995 Chinese insulin-naïve T2DM patients who initiated BI therapy due to uncontrolled hyperglycemia by OADs. The type and dose of BI as well as other treatment regimens depended on physician’s discretion and patient’s willingness. Proportion of patients initiating basal-bolus insulin and associated factors were analyzed. Results: Basal-bolus accounted for 24.6% of patients initiating BI, of whom 97.8% initiated a full basal-bolus regimen. In the multivariate logistic regression, factors significantly associated with initiating basal-bolus regimen were tertiary hospital, in-patients, younger age, higher BMI, longer diabetes duration, more complications, higher HbA1c level, low self-monitoring of blood glucose (SMBG) frequency before, one OAD used before, no concomitant OAD, and initiating Neutral Protamine Hagedorn (NPH). About half of patients initiating basal-bolus persisted on the same insulin regimen at 3-month. Glycemic control rates (HbA1c<7%) at 6 months were 37.6% and 41.8% in basal-bolus and BI alone, respectively (p<0.0001). In patients with at least one complication, basal-bolus showed significantly lower glycemic control compared with BI alone (33.4% vs 39.8%, P<0.0001). Conclusions: The findings suggest a high proportion of patients with T2DM initiating basal-bolus insulin. Tertiary hospital, in-patients, younger age, higher BMI, longer diabetes duration, more complications, higher HbA1c level, low SMBG frequency before, one OAD used before, no concomitant OAD, and concomitant NPH were related to higher odds of initiating basal-bolus.
Molecular Investigation of Tick-Borne Pathogens in Ticks removed from Tick-Bitten Humans in the Republic of Korea
Authors: Bang Mi-Seon , Kim Choon-Mee , Pyun Sang-Hyun , Kim Dong-Min , Yun Na Ra
Published: December 2019

Background Tick-borne infections are continuously increasing due to climate change, increased outdoor activities and increased travel between countries. This study was to investigate the presence of tick-borne pathogens in ticks removed from tick-bitten humans in southwest provinces of Republic of Korea (ROK). Methods Ticks were obtained from those tick-bitten humans between May 2014 and September 2017 in Jeollanam provinces and Gwangju metropolitan city in ROK. The presence of the tick-borne pathogens in ticks removed from tick-bitten humans was analyzed using pathogen-specific polymerase chain reaction (PCR). Results We identified 33 ticks from three tick species, namely Amblyomma testudinarium (60.6%), Haemaphysalis longicornis (27.3%), and Ixodes nipponensis (12.1%) in order of occurrence by morphology and 16S rDNA-targeting PCR. Tick-borne pathogens were found in 16 ticks using pathogen-specific PCR. From the results, 12 ticks (36.4%) tested positive for spotted fever group (SFG) Rickettsia: Rickettsia monacensis (1/12), R. tamurae (8/12), and Candidatus Rickettsia jingxinensis (3/12). Three ticks (9.1%) were positive for Anaplasma phagocytophilum . In addition, three ticks (9.1%) tested positive for Babesia gibsoni (1/3) and B. microti (2/3). Conclusions In conclusion, we identified three tick species; the most common species was A. testudinarium followed by H. longicornis and I. nipponensis . SFG Rickettsia , A. phagocytophilum , and Babesia spp. were the most frequently detected pathogens in ticks removed from tick-bitten humans. R. tamurae and Ca. R. jingxinensis were firstly detected in Korea. The present results will contribute to the understanding of tick-borne infections in animals and humans in the ROK.
Knowledge and Awareness among mothers regarding exclusive breastfeeding in holy Karbala city / Iraq
Authors: Al-Nasrawii maytham salim , Al-Aaragi Ali Neamah , Mohammed Ali Abd Al-Latif G
Published: December 2019

Background: World Health Organization (WHO) and United Nations Children’s Fund (UNICEF) “Exclusive breastfeeding (EBF)” is explained as “the infant receives only breast milk, no other liquids or solids. Its recommended for the first 6 months of life, and then complementary feeding should be started. EBF helps to reduce child morbidity and mortality from several diseases such as diarrhea, respiratory and /or ear infections and other infectious diseases, shielding lactation women from breast and ovarian cancer. In addition to offers societal economic and environmental benefits, The objective of this study was to assess the knowledge and awareness of exclusive breast feeding among mothers with a child < 2 years of age. Methods : A descriptive cross-sectional study was carried out in Health Directorate of Holy Karbala city. The study consist of (487) mothers how attendant to six Primary Health Care center (PHC). The collected data was done by direct interview with mothers and using a questionnaire form that designed based on the study objectives according to WHO criteria. Data were analyzed by SPSS, descriptive statistics included numbers (N) and percentage (%), and the inferential statistical test was done by using Chi-Square test , P-value was equal or less than 0.05 considered as statistically significant to find for any association between the results variables. Result : A total of 487 participants were included in the study, the rate of response was 92.7%. The highest percentage (66.3%) of study sample were full in the age group (21-30) years, and more than three quarters were lived in urban area. Nearly half of the study sample 47% had primary education and 60% those housewives, and the main source of information being family and friends (84.4%). As an overall assessment, 61.8% of the study sample had good knowledge and awareness about exclusive Breastfeeding, with highly significant differences to education level ,occupation residence of the mother. Conclusion: Over half of the subjects had good knowledge and awareness of exclusive Breastfeeding. And, on the other hand, there was a very significant difference between education level, occupation and mother's residence with a level of knowledge.
Incidence and Predictors of Sever Adverse Drug Reactions Among Patients on Antiretroviral Therapy at Debre Markos Referral Hospital, Northwest Ethiopia
Authors: Kibret Getiye Dejenu , Ayele Tadesse Awoke , Tesfahun Adino
Published: December 2019

Background: Due to its nature of chronicity and the trend of using more drugs for patients with HIV, antiretroviral toxicity becomes a major challenge of HIV management. Evidences revealed that magnitude of experiencing at least one form of drug toxicity in different setting have been reached up to 90% among patients on antiretroviral therapy. The main aim of this study was to estimate the incidence and predictors of severe adverse drug reactions among People Living with Human Immunodeficiency Virus (PLHIV) at Debre Markos Referral Hospital.
Methods: Retrospective follow up study with survival analysis was carried out among people living with Human Immunodeficiency virus. Mean survival time of the cohort was estimated using Kaplan-Meier method. To model the relationship between explanatory variables and the time to adverse drug reaction, Cox-proportional hazard regression model was fitted.
Results: Out of the total 485 participants 67 (13.81%; 95% C.I: 10.7%, 16.8%) had experienced sever adverse drug reactions (ADRs). The incidence rate of severe adverse drug reaction development was 3 per 100-person years.
Patients residing out of the catchment area to the facility were 73% at higher risk to develop ADR at any time, compared to those living within the catchment area (AHR=1.73; 95% C.I: 1.04, 2.86). The risk of ADRs among patients with baseline WHO clinical stage of III and IV was 2.59 times higher at any time compared to those with WHO stages I and II (95% C.I: 1.54, 4.36).
Conclusion: The incidence of adverse drug reactions was relatively lower than reported in different parts of Ethiopia and other African countries. However, the overall burden in the 10 years period was still high. Health professionals working in the ART clinic need to give special attention for patients coming from outside of catchment areas, commercial sex workers and drivers and patients on advanced WHO clinical stages to prevent ADR development among these groups.
Implications of Development Bank Finance on the Growth and Development of Msmes in Nigeria (2010-2017)
Authors: Adeyinka Ad. J. , Abdulkarim M. , Odi N.
Published: December 2019

Developing a sustainable source of finance for MSMEs has remained a perennial problem as a result of their poor accounting systems and lack of, or low-valued collaterals. This study examined the impact of development bank finance on the growth and development of MSMEs in Nigeria from 2010 – 2017 with specific objectives of determining whether MSMEs have poor accounting systems, the extent to which SMEs financing depend on sound accounting practices and whether MSMEs funding depend on collateral using the survey research design method. Ordinary Least Square Regression (OLS) Technique was used to analyse the data obtained from primary and secondary sources. The study found that MSMEs in Nigeria have a poor accounting practice, access to finances by MSMEs depend largely on a sound accounting practice and that the volume and value of credits to MSMEs depend on the availability of collaterals. The study recommends that SMEs should install a sound internal control system MSMEs should ensure a sound accounting practice that conforms with the internationally accepted accounting standards in order to boost their access to funding, and MSMEs should invest a portion of their capital in non-current assets in order to increase the value of their collaterals and, hence, have expansive access to funding.
Keywords: Sound Accounting Practices, Collateral, Non-Current Assets, and funding.
Asset Pricing Models and Stock Selection Ability of the Indian Mutual Fund Managers: An Empirical Study of Open-ended Growth Equity Schemes
Authors: Gupta Kamal
Published: December 2019

The paper is devoted to the study of the analysis and forecasting of the possibility of joint investment Fund managers to choose securities for further investment. The methodological tools of the work are presented by models Jensen, Fama & amp; French and Carhart (which allow to assess the ability to select securities by managers of mutual funds). Empirical estimates of the analysis on three models showed that Indian mutual Fund managers have the ability to choose stocks. The author states that the analysis based on the Jensen model characterizes higher potential opportunities for the selection of securities by the managers of India’s joint-stock funds compared to the other two models used in the study. The results of the study can be useful for investors in making investment decisions, in particular in the process of placing their own financial resources in joint investment funds. The paper postulates that investors will be able to choose joint investment schemes in favor of funds, which provide the opportunity to choose securities for investment for more than ten years. The author notes that the key effect of the introduction of such a practice of interaction between investors and funds will be the growth of investor confidence, which will contribute to the accumulation of additional volumes of investments in the joint investment sector. This study is limited only to the schemes of investing their own financial resources, but in the future can be further expanded to the practice of using a wide range of schemes, since the possibility of choosing shares is associated with many financial processes and indicators. Since the study of asset pricing models is a continuous process, the author proposed to study the processes of joint investment in pension funds in the context of assessing the impact of financial indicators such as liquidity, return on investment, profitability.

Keywords: investors, funds of collective investment, the ability to stock selection, patterns of growth equity capital.
Radviliškio X ikimokyklinio ugdymo įstaigos pedagogių požiūris į vaikų elgesio kultūros ugdymą(si)
Authors: Smilgienė Jurgita , Jankutė Kristina
Published: December 2019

Lietuvos visuomenė gyvena permainų laikotarpiu, kuriame asmeninės vertybės yra veikiamos mus supančios aplinkos. Pastebėtas visuomenės narių elgesio kultūros prastėjimas ir vis dažniau tai būdinga vaikų ir jaunimo elgsenai. Vaikai praranda savarankiškumo, pagarbos asmeniui, tautai jausmus, vis dažniau matomas šiurkštus bendravimas, nepakantumas aplinkai, o tai tik įrodo, kad mūsų jaunoji karta pasižymi žema elgesio kultūra. Kuo anksčiau supažindinsime vaikus su pagrindinėmis elgesio kultūros vertybėmis ir sieksime jas ugdyti, tikėtina, jog pasieksime geresnių rezultatų tinkamo elgesio modeliavimui gyvenimui visuomenėje. Dėl šios priežasties ne tik šeima, bet ir ikimokyklinio ugdymo įstaiga tampa atsakinga už vaikų elgesio kultūros ugdymą, švietimą ir skatinimą elgtis mandagiai, pagarbiai, sąžiningai, draugiškai ir t. t.Straipsnio tikslas – atskleisti, koks yra ikimokyklinių ugdymo įstaigų pedagogių požiūris į vaikų elgesio kultūros ugdymą(si) ikimokykliniame amžiuje.Atliktas tyrimas vienoje iš Radviliškio ikimokyklinio ugdymo įstaigų siekiant išsiaiškinti, kiek svarbus yra elgesio kultūros ugdymas(is) ikimokyklinėje ugdymo įstaigoje ir koks yra pedagogių požiūris šiuo aspektu. Tikslui įgyvendinti pasirinkta kokybinio tyrimo strategija. Atlikta ikimokyklinių ugdymo(si) įstaigų pedagogių anketinė apklausa raštu, duomenys apdoroti turinio analizės metodu.Tyrimo rezultatai atskleidė, kad elgesio kultūros sąvokos samprata plati, nes ją sudaro ne tik veiklos, bendravimo, higienos kultūra, bet ir ekologinis bei tautinis ugdymas(is). Anot pedagogių, didžiausia atsakomybė už vaikų elgesio kultūros ugdymą atitenka ugdytinių šeimoms. Ugdymo įstaigos įvardijamos kaip papildomi institutai, prisidedantys prie vaikų elgesio kultūros ugdymo(si).
Aspectos Socioeconômicos, Produtivos e Sanitários da Fabricação de Queijo Coalho em Jaguaribe, Ceará
Authors: Da Silva Francisca Klécia Bernardino , Santos Luana Maria de Lima , Soares Valdineia Freitas
Published: December 2019

A produção artesanal do queijo de coalho em Jaguaribe tem se constituído em uma importante estratégia para o desenvolvimento socioeconômico de muitas famílias, desde seu início quando se destinava ao aproveitamento do excedente de leite, até os dias atuais, como estratégia de agregação de valor ao leite in natura. Frente à importância desta atividade para o município, o presente estudo objetivou conhecer os aspectos socioeconômicos, produtivos e sanitários da fabricação do queijo de coalho em Jaguaribe, Ceará. Participaram desta pesquisa vinte e cinto produtores de queijo cujos estabelecimentos situam-se na sede do munícipio. Os aspectos socioeconômicos, produtivos e de infraestrutura foram avaliados por meio de questionários semiestruturados aplicados aos participantes. Diante disto se conclui que, embora a produção de queijo de coalho apresente caráter informal, ela contribui significativamente para a geração de renda local afirmando-se como atividade familiar. De acordo com os produtores, a adoção de políticas públicas, e a facilidade de acesso ao crédito podem contribuir para o aumento da competitividade e a sua consolidação no mercado.
A Importância da Excelência no Atendimento como Diferencial Competitivo para a Empresa Hoteleira: Estudo de Caso em uma Pousada em Canoa Quebrada - Aracati/CE
Authors: De Sousa Viegas Nunes Mônica , De Oliveira Ribeiro Angélica
Published: December 2019

Pretende-se demonstrar neste artigo a importância da qualidade dos serviços para uma empresa hoteleira manter-se competitiva, pois a qualidade é o fator de sobrevivência nos meios de hospedagem. Além disso, devem ser adotadas ações pela empresa hoteleira a fim de garantir uma qualidade dos serviços, uma vez que a qualidade dos serviços influencia na fidelização dos clientes. Essa pesquisa foi aplicada na Pousada Via Láctea – Canoa Quebrada – Aracati/CE, e teve como objetivo geral identificar o grau de satisfação dos clientes quanto à qualidade dos serviços oferecidos na empresa hoteleira, e como objetivos específicos verificar como os clientes são tratados pelos funcionários no empreendimento hoteleiro; verificar os pontos negativos e positivos quanto à qualidade dos serviços de acordo com a perspectiva dos clientes; propor ações que venham a melhorar a qualidade dos serviços aos clientes e identificar as principais dificuldades em manter a qualidade dos serviços. Em relação à metodologia aplicada, trata se de um estudo exploratório descritivo, com a utilização de pesquisa de campo. Com a realização da pesquisa concluiu-se que o resultado da análise dos dados coletados foi satisfatório, o que mostra que a Pousada Via Láctea possui qualidade nos serviços prestados, o que torna um diferencial competitivo frente aos outros empreendimentos hoteleiros. E, além disso, constatou-se que os hóspedes são clientes novos que precisam ser fidelizados. Portanto, uma empresa hoteleira deve ser capaz de satisfazer as necessidades dos clientes e superar as suas expectativas, conquistando assim sua fidelização.
Análise Mecânica de um Solo Areno-Argiloso Estabilizado com Cal para Fins de Pavimentação
Authors: Oliveira Viviane de Araújo , Lima Mayara da Silva , Farias Teresa Raquel Lima
Published: December 2019

Identifica-se no Estado do Ceará, dificuldade de se encontrar solos que satisfaçam as condições impostas pelas especificações tradicionais para a construção de pavimentos. Devido a este fato, torna-se necessário, por vezes, recorrer a alternativas, como a estabilização desses materiais. Visando a economia dos custos no transporte de materiais até o local de execução da obra e a obtenção de materiais que atendam às especificações de projeto, este artigo tem por objetivo analisar a viabilidade técnica de um solo com características argilosas por meio da estabilização química com a adição da cal em pó. O estudo foi sistematizado em duas etapas: a primeira abrangeu ensaios de caracterização e a segunda consistiu na determinação de Índice de Suporte Califórnia, Resistência à Compressão Simples e aplicação do método de dosagem proposto por Thompson (1966). Os resultados mostraram que com 3% de cal em pó, o solo tornou-se reativo, bem como manifestou melhorias no que diz respeito às suas propriedades físicas. Entretanto, melhor resultado foi obtido para a mistura solo-cal com teor de 5%. Recomenda-se, então, para o tipo de solo analisado, o uso de 5% desse estabilizante. Esse teor justifica-se porque apresentou melhores resultados de resistência à compressão, atingiu valores de resistência superiores aos mínimos exigidos em projetos de pavimentos. De maneira abrangente, as misturas de solo-cal apresentaram comportamento favorável para a execução de camadas de base e sub-base de pavimentos, destacando-se como uma alternativa para a pavimentação.
Caracterização Físico-Química Preliminar dos Efluentes da Incineração de Resíduos Perigosos de Fortaleza-CE
Authors: Da Silva Rilton Bruno Lima , Santos Gemmelle Oliveira
Published: December 2019

O objetivo da pesquisa foi caracterizar, do ponto de vista físico-químico, os efluentes provenientes da lavagem dos gases da incineração de resíduos sólidos perigosos realizada em um equipamento de grande porte em funcionamento em Fortaleza-CE. Foi realizada descrição do equipamento, e do processo de geração e tratamento de efluentes. As análises de laboratório ocorreram entre os meses de abril e setembro de 2016 (6 coletas na entrada e 6 coletas na saída da estação de tratamento de efluentes). Dentre os 10 parâmetros analisados, 5 apresentaram redução em suas concentrações após o tratamento em todas as campanhas (sólidos suspensos totais, turbidez, cor verdadeira, demanda química de oxigênio e alcalinidade total). Foi possível observar que os valores máximos de remoção alcançaram 90% para os sólidos suspensos totais, 81% para a cor verdadeira, 92% para turbidez, 56% para DQO e 68% para alcalinidade total. Essa é a primeira pesquisa sobre a qualidade dos efluentes da incineração de resíduos perigosos em Fortaleza, e seus dados primários poderão servir de base para outras pesquisas. Em linhas gerais, os efluentes estudados têm forte carga físico-química, mas seu uso cíclico (lavagem de gases - ETE - lavagem de gases) mantém sob controle seus riscos de poluição ou contaminação ambiental.
The determinants of Islamic governance disclosure: the case of Indonesian Islamic banks
Authors: Nurkhin Ahmad , Wahyudin Agus , Mukhibad Hasan , Fachrurrozie  , Yoga Baswara Satsya
Published: December 2019

This paper aims to examine the determinants of Islamic Governance Disclosure (IGD) in Islamic banks in Indonesia. The research method used is a quantitative approach involving Islamic commercial banks in Indonesia, where their annual reports can be accessed during the 2011–2018 observation period. The data collection methods used are analysis of documentation and content analysis. Content analysis was used to calculate the IGD index. Path analysis with WarpPLS software was used to analyze data. The results show that the number of members of the Sharia supervisory board had a negative and significant effect on IGD, while leverage, size, and age can influence the IGD positively and significantly. In addition, institutional ownership has a negative and significant effect on IGD. Profitability and composition of the independent board of commissioners do not significantly affect the IGD.
O ESTADO DE COISAS INCONSTITUCIONAIS: CAMINHOS ADOTADOS PELO JUDICIÁRIO BRASILEIRO
Authors: Lima Renata Miranda , Albuquerque Carolina De
Published: December 2019

O presente estudo se volta às mulheres negras, universitárias, moradoras do distrito do M´boi Mirim – zona Sul / São Paulo com a finalidade de compreender o entrelaçamento do Direito a Mobilidade Urbano-Periférica com o Direito à Educação Superior. Para tanto, foi utilizada a observação qualitativa como estratégia metodológica, entrevistas semiestruturadas e uso de diário de campo. A partir do exposto conclui-se que: a mulher negra, moradora da periferia que está acessando o ensino superior, encontra no seu caminho de permanência na universidade, um bombardeio de dificuldades. Entretanto, essas mulheres reexistem, resignificam e resistem por influência da família, por quererem atingir seus objetivos, sonhos e buscarem na educação uma mobilidade social para si e para sua família. Assim, resumo a força que as impulsionam na seguinte canção: “Planta do pé tá no chão.Sangue dos meus ancestrais no coração.Alcançando a vitória com as próprias mãos. Alcançando a vitória com as próprias mãos. Com as próprias mãos.Se é pra vencer deixa quem sabe fazer. Eu tô na luta, sou mulher.Posso ser o que eu quiser”.(Karol ConK: Tô na luta).
BASE NATURAL DO ORDENAMENTO JURÍDICO
Authors: Rodrigues Denis Leite
Published: December 2019

O artigo versa sobre a base natural do ordenamento jurídico, ou seja, considera o direito natural como parte do ordenamento jurídico estatal. Busca este estudo, inicialmente, esclarecer os principais conceitos ligados à matéria, e, a partir daí, expor as considerações de diferentes correntes filosófico-jurídicas que, respectivamente, foram a fonte básica dos escritos e ensinamentos relativos ao direito natural. Ao final, há também uma confrontação com posições doutrinárias que divergem da posição de considerar o direito natural como parte do direito social e efetivamente aplicado. O estudo é desenvolvido através da análise de diversas obras doutrinárias, e dele resulta dois pontos até certo ponto opostos e paradoxais: de um lado, uma inicial tendência do crescimento do pensamento cada vez mais de natureza notada e unicamente temporal para a análise jurídica; e, de outro, a resposta fática da retomada do fundamento também divino para a construção de uma ordem jurídica (como reação, por exemplo, às guerras do século XX).
Política regional e projeção de interesses privados:
Authors: Honorio Karen dos Santos
Published: December 2019

O artigo tem como objetivo discutir o papel da América do Sul na política externa dos governos de Luiz Inácio Lula da Silva (2003-2010). Desenvolve-se ao longo do texto o argumento de que a América do Sul foi o espaço prioritário de articulação da orientação Sul-Sul da política externa e da projeção econômica dos interesses de atores privados do capitalismo brasileiro, sob o modelo neodesenvolvimentista, a partir de uma dupla presença (política e econômica) do país na região. Nesse sentido, a política externa brasileira para a América do Sul conciliou em sua estratégia e ação: 1) a projeção de interesses de determinados setores privados nacionais no subcontinente; 2) o estabelecimento de mecanismos de governança política regional e, 3) a construção de uma agenda bilateral e multilateral que fortaleceu áreas e temáticas em consonância com o modelo de desenvolvimento adotado pelo governo no período. A discussão apresentada no artigo visa contribuir para os estudos de análise da política externa dos governos Lula e a compreensão do papel da América do Sul na estratégia internacional brasileira do período.
Interculturality From Periphery
Authors: Nieves Loja Gerardo Miguel
Published: December 2019

The purpose of this paper is to indicate the sector around which the new reflections and epistemological horizons of interculturality revolve and are articulated. This sector consists of the excluded, the indigenous peoples and the poor in rights. In these spaces of intercultural reflection, various analyses are required in order to promote a participative culture capable of relying on its own sources and ancient knowledge; to this end, both a liberating pedagogy and the establishment of laws that defend victims (man and nature) are needed. This will lead to the creation of an intercultural society.
El debate en torno a la noción de “inmutación espiritual”: ¿contradicción o síntesis en la gnoseología de Tomás de Aquino?
Authors: Hernandez Fernando
Published: December 2019

Este trabajo tiene como objetivo aportar nuevos elementos al debate que se sostuvo en Tópicos, Revista de Filosofía entre Ezequiel Téllez Maqueo y Jörg Alejandro Tellkamp sobre la teoría del conocimiento sensible de Tomas de Aquino. Los conceptos de spiritus e immutatio spiritualis serán la pieza clave para resolver la disyuntiva entre la coherencia o inconsistencia de dicha teoría.
TÜRKİYE’DE İÇ GÖÇÜN DAĞILIMI
Authors: ŞANTAŞ Gülcan
Published: December 2019

This study was carried out to examine the internal
migration conceptually and to determine the distribution of internal migration
in Turkey. For the purposes of the study, 1993-1998-2003-2008 and 2013 data of
Turkey Demographic and Health Survey (TDHS), published by Hacettepe University
Institute of Population Studies, were used in the study. The population of the
study consists of women in reproductive ages in the TDHSs. The weighted
sampling method, multi-stage sampling method and stratified cluster sampling
methods were used in sampling in the research. The sample of the research was
6519 women in the 1993 research, 8576 women in the 1998 research, 8075 women in
the 2003 research, 7405 women in the 2008 study and 9746 women in the 2013
study. The migration variable was determined by the childhood residential area
of women in the study. In the results of the study, it has been identified that
the percentage of people living in urban areas has increased continuously, and
more than 60% of women at secondary and higher education level live in urban
areas for five research period.  Also the
percentage of living in cities was found higher in women who were unmarried,
unemployed, those with health insurance and living in the Western Region.
MEMBANGUN KECERDASAN FINANSIAL DENGAN MATEMATIKA KEUANGAN
Authors: Romadiastri Yulia
Published: December 2019

Setelah IQ (Intellectual Quotient), EQ (Emotional Quo- tient), SQ (Spiritual Quotient), sekarang muncul FQ (Finan- cial Quotient) atau biasa disebut kecerdasan finansial. Hal ini dikarenakan salah satu cabang dalam ilmu keuangan yang berkembang pesat dalam beberapa tahun belakan- gan ini adalah perencanaan keuangan atau financial plan- ning. Pada prinsipnya merencanakan keuangan yang baik itu mudah dan semua orang dapat melakukannya sendiri. Untuk dapat melakukannya, seseorang hanya perlu me- mahami matematika keuangan dan memiliki pengetahuan tentang produk pasar modal dan pasar uang yang tersedia. Pemahaman   akan matematika keuangan membuat ses- eorang menjadi cerdas finansial dan memungkinkan untuk menyusun sendiri perencanaan keuangannya.
ORIENTASI LIFE SKIL DALAM KURIKULUM TINGKAT SATUAN PENDIDIKAN DENGAN PENDEKATAN SETS (Science Environment Technology & Society) PADA JENJANG PENDIDIKAN DASAR & MENENGAH
Authors: L Listyono
Published: December 2019

Kurikulum Tingkat Satuan Pendidikan (KTSP) adalah se- buah kurikulum operasional pendidikan yang disusun oleh dan dilaksanakan di masing-masing satuan pendidikan di Indonesia. KTSP secara yuridis diamanatkan oleh Undang-Undang Nomor20 Tahun 2003 tentang Sistem Pendidikan Nasional dan Per- aturan Pemerintah Republik Indonesia Nomor 19 Tahun 2005 tentang Standar Nasional Pendidikan. KTSP merupakan bagian yang tidak terpisahkan dari SI, namun pengembangannya dis- erahkan kepada sekolah agar sesuai dengan kebutuhan sekolah itu sendiri. Basis dari kurikulum ini adalah kompetensi yang ha- rus dikuasai oleh siswa. Kompetensi merupakan pengetahuan, ketrampilan dan nilai-nilai yang direfleksikan dalam kebiasaan berfikir dan bertindak.
ISOLASI DAN KARAKTERISASI ASAM HUMAT DARI TANAH GAMBUT
Authors: Rahmawati Atik
Published: December 2019

Telah dilakukan penelitian tentang isolasi dan kara- kterisasi asam humat hasil isolasi tanah gambut yang be- rasal dari Desa Sambutan, Kecamatan Samarinda Ilir, Sa- marinda, Kalimantan Timur.Isolasi asam humat dari tanah gambut menggunakan metode ekstraksi alkali,  pemurnian dan penentuan kand- ungan gugus fungsional asam humat secara titrasi poten- siometri.Hasil penelitian menunjukkan gugus fungsional utama asam humat hasil isolasi tanah gambut adalah gu- gus –COOH dan gugus –OH. Secara kuantitatif kandungan gugus fungsional tersebut masing-masing sebesar 426,2 cmol/kg (gugus –COOH), 289,6 cmol/kg (gugus –OH fenolat) dan 37,0 cmol/kg (gugus –OH alkoholat).
PEMBUATAN ALAT LABORATORIUM FISIKA FAKULTAS ILMU TARBIYAH DAN KEGURUAN IAIN WALISONGO UNTUK PRAKTIKUM OSILASI CAIRAN DAN AYUNAN MATEMATIS SECARA DIGITAL
Authors: Sudarmanto Agus
Published: December 2019

Penelitian ini merancang dan merealisasikan pembua- tan alat laboratorium Fisika Fakultas Tarbiyah IAIN secara digital yaitu pada praktikum osilasi cairan dan ayunan matematis.Pembuatan alat laboratorium Fisika Fakultas Ilmu Tar- biyah dan Keguruan IAIN Walisongo untuk praktikum osi- lasi cairan dan ayunan matematis secara digital terdiri dari sumber cahaya, sensor cahaya yang keluarannya, dengan keypad sebagai masukannya kemudian diproses dengan mikrokontroler ATMega8535 dengan algoritma program kemudian hasilnya ditampilkan pada LCD (Liquid Cristal Display).Hasil penelitian ini adalah bahwa pembuatan alat lab- oratorium sika  untuk praktikum osilasi cairan dan ayu- nan matematis secara digital sudah dapat berfungsi sesuai dengan yang diinginkan dan data hasil dari alat tersebut mendekati nilai percepatan gravitasi bumi sebenarnya yai- tu sebesar 9,8 m/s2.
Klasifikasi Pemahaman Santri Dalam Pembelajaran Kitab Kuning Menggunakan Algoritma Naive Bayes Berbasis Forward Selection
Authors: Mahfudh Adzhal Arwani , Mustofa Hery
Published: December 2019

Kitab kuning merupakan kitab tradisional yang mengandung diraasah islamiyah yang diajarakan pada pondok pesantren, mulai dari struktur bahasa arab (ilmu nahwu dan shorof), ‘ulumul qur’an, hadits, aqidah, tasawuf/akhlaq, tafsir, fiqh sampai ilmu sosial dan kemasyarakatan (mu’amalah).  Disebut juga dengan kitab gundul karena tidak memiliki harakat (fathah, kasroh, dhammah, sukun) untuk bisa membaca dan memahami secara menyeluruh dibutuhkan waktu yang relatif lama. Penelitian ini bertujuan untuk mendapatkan model klasifikasi dari data pembelajaran kitab kuning di pondok pesantren. Metode yang digunakan dalam penelitian ini adalah forward selection sebagai praproses dalam mengurangi dimensi data, menghilangkan data yang tidak relevan dan naive bayes yang berguna untuk mengklasifikasi data. Hasil dari klasifikasi data pembelajaran kitab kuning menggunakan atribut yang telah diklasifikasi berdasarkan fitur-fiturnya dan dilakukan iterasi pada cross validation sehingga menghasilkan akurasi yang tepat. Berdasarkan hasil pengujian dengan dua metode, pengujian dengan algoritma Naive bayes saja menghasilkan akurasi 96,02%, untuk algoritma Naive bayes berbasis forward selection menghasilkan akurasi 97,38% . Terdapat peningkatan akurasi dengan penambahan fitur seleksi.
Fractional factorial design modelling on degradation of Direct Red 81 dye by advanced oxidation process – ozonation: reaction kinetics
Authors: Muniyasamy Abaranjitha , Sivaporul Gayathri , Gopinath Abarna , John Juliana , Achary Anant , Chellam Padmanaban Velayudhaperumal
Published: December 2019

In the present work, the degradation of Direct Red 81 by ozonation was studied. The interactive effects of the influencing factors (dye concentration = 500–2,000 mg/L; time = 10–30 min; pH = 7.0–11.0) on degradation efficiency was critically examined through experimental design optimization by central composite design under the response surface methodology. The high correlation coefficients (R2 = 0.976 & adjusted R2 = 0.958) obtained by analysis of variance (ANOVA) demonstrated close fit between the experimental and the predicted values. Optimized conditions under specified cost-driven restraints were obtained for the highest desirability (i.e. degradation of 1,210.59 mg/L dye) at pH = 11.0, initial dye concentration = 2,000 mg/L and ozone exposure time of 27.16 min. The degradation of Direct Red 81 was confirmed through Fourier transform infrared spectroscopy (FTIR) analysis and UV-Vis spectrometry.
Nutritional analysis of noodles with and without the additional of Pereskia aculeata
Authors: ZEM Luciele Milani , HELM Cristiane Vieira , KOEHLER Henrique Soares , ZUFFELLATO-RIBAS Katia Christina
Published: December 2019

Pereskia aculeata Mill. is a cactaceous, popularly known as ora-pro-nobis, considered a native and non-endemic vegetables besides being rich in protein, fiber, iron and calcium, among others. This work aimed to study the chemical composition of noodles prepared with the incorporation of dry leaves flour, stems and fresh leaves of Pereskia aculeata, to identify and quantify the nutrients and minerals present. Four recipes were tested: traditional noodles with flour; noodles with incorporating flour from dried leaves; noodles with leaves flour incorporation + stem; noodles with incorporation of fresh leaves. The following analyzes were carried out in a completely randomized design with three replications, and data expressed in percentage in wet and dry basis (g 100g-1): moisture, ash, protein, fiber, lipids, total carbohydrates, total caloric value and minerals. Among the tested recipes, it was concluded that the noodles with incorporating flour dried leaves of Pereskia aculeata showed the best moisture, ash, lipids, proteins, fibers and lower total caloric values. Furthermore, it showed the best results for all analyzed minerals, thus the better nutritional quality.