bluuebunny/crossref_metadata_2025 huggingface dataset:
The Potential of Honey as a Prebiotic Food to Re-engineer the Gut Microbiome Toward a Healthy State
Authors: Schell Kathleen R. , Fernandes Kenya E. , Shanahan Erin , Wilson Isabella , Blair Shona E. , Carter Dee A. , Cokcetin Nural N.
Published: July 2022

Honey has a long history of use for the treatment of digestive ailments. Certain honey types have well-established bioactive properties including antibacterial and anti-inflammatory activities. In addition, honey contains non-digestible carbohydrates in the form of oligosaccharides, and there is increasing evidence from in vitro, animal, and pilot human studies that some kinds of honey have prebiotic activity. Prebiotics are foods or compounds, such as non-digestible carbohydrates, that are used to promote specific, favorable changes in the composition and function of the gut microbiota. The gut microbiota plays a critical role in human health and well-being, with disturbances to the balance of these organisms linked to gut inflammation and the development and progression of numerous conditions, such as colon cancer, irritable bowel syndrome, obesity, and mental health issues. Consequently, there is increasing interest in manipulating the gut microbiota to a more favorable balance as a way of improving health by dietary means. Current research suggests that certain kinds of honey can reduce the presence of infection-causing bacteria in the gut including Salmonella, Escherichia coli, and Clostridiodes difficile, while simultaneously stimulating the growth of potentially beneficial species, such as Lactobacillus and Bifidobacteria. In this paper, we review the current and growing evidence that shows the prebiotic potential of honey to promote healthy gut function, regulate the microbial communities in the gut, and reduce infection and inflammation. We outline gaps in knowledge and explore the potential of honey as a viable option to promote or re-engineer a healthy gut microbiome.
A-Kinase Interacting Protein 1 Knockdown Restores Chemosensitivity via Inactivating PI3K/AKT and β-Catenin Pathways in Anaplastic Thyroid Carcinoma
Authors: Zheng Haiyan , Lin Qingyuan , Rao Yamin
Published: July 2022

Background

A-kinase interacting protein 1 (AKIP1) promotes tumor progression and chemoresistance in several malignancies; meanwhile, it is related to higher tumor size and recurrence risk of papillary thyroid carcinoma, while the role of AKIP1 in anaplastic thyroid carcinoma (ATC) is unclear. The aim of this study is to explore the effect of AKIP1 knockdown on cell malignant behaviors and doxorubicin resistance in ATC.

Methods

AKIP1 knockdown was conducted in ATC cell lines (8505C and CAL-62 cells) by siRNA; then, cell viability, apoptosis, invasion, PI3K/AKT and β-catenin pathways, and doxorubicin sensitivity were detected. Subsequently, doxorubicin-resistant 8505C cells (8505C/Dox) were established. Additionally, AKIP1 was modified in 8505C and 8505C/Dox cells that underwent doxorubicin treatment by siRNA or overexpression plasmid, followed by cellular function and pathway detection.

Results

AKIP1 was elevated in FRO, 8505C, CAL-62, and KHM-5M cells compared to control cells (all p < 0.05). Subsequently, AKIP1 knockdown elevated apoptosis, inhibited viability and invasion, and inactivated PI3K/AKT and β-catenin pathways in 8505C and CAL-62 cells (all p < 0.05). AKIP1 knockdown decreased relative cell viability in doxorubicin-treated 8505C and CAL-62 cells; then, AKIP1 was elevated in 8505C/Dox cells compared to 8505C cells (all p < 0.05). Furthermore, AKIP1 knockdown restored doxorubicin sensitivity (reflected by decreased cell viability and invasion, and increased apoptosis), but inactivated PI3K/AKT and β-catenin pathways in doxorubicin-treated 8505C/Dox cells. However, AKIP1 overexpression presented an opposite effect on these functions and pathways in doxorubicin-treated 8505C cells.

Conclusion

AKIP1 knockdown decreases cell survival and invasion while promoting sensitivity to doxorubicin via inactivating PI3K/AKT and β-catenin pathways in ATC.
Structure boundary-preserving U-Net for prostate ultrasound image segmentation
Authors: Bi Hui , Sun Jiawei , Jiang Yibo , Ni Xinye , Shu Huazhong
Published: July 2022

Prostate cancer diagnosis is performed under ultrasound-guided puncture for pathological cell extraction. However, determining accurate prostate location remains a challenge from two aspects: (1) prostate boundary in ultrasound images is always ambiguous; (2) the delineation of radiologists always occupies multiple pixels, leading to many disturbing points around the actual contour. We proposed a boundary structure-preserving U-Net (BSP U-Net) in this paper to achieve precise prostate contour. BSP U-Net incorporates prostate shape prior to traditional U-Net. The prior shape is built by the key point selection module, which is an active shape model-based method. Then, the module plugs into the traditional U-Net structure network to achieve prostate segmentation. The experiments were conducted on two datasets: PH2 + ISBI 2016 challenge and our private prostate ultrasound dataset. The results on PH2 + ISBI 2016 challenge achieved a Dice similarity coefficient (DSC) of 95.94% and a Jaccard coefficient (JC) of 88.58%. The results of prostate contour based on our method achieved a higher pixel accuracy of 97.05%, a mean intersection over union of 93.65%, a DSC of 92.54%, and a JC of 93.16%. The experimental results show that the proposed BSP U-Net has good performance on PH2 + ISBI 2016 challenge and prostate ultrasound image segmentation and outperforms other state-of-the-art methods.
Cell Death Triggers Induce MLKL Cleavage in Multiple Myeloma Cells, Which may Promote Cell Death
Authors: Chen Jing , Wang Shiyu , Blokhuis Bart , Ruijtenbeek Rob , Garssen Johan , Redegeld Frank
Published: July 2022

Necroptosis is a type of caspase-independent programmed cell death that has been implicated in cancer development. Activation of the canonical necroptotic pathway is often characterized with successive signaling events as the phosphorylation of mixed lineage kinase domain-like (MLKL) by receptor-interacting protein kinase-3 (RIPK3), followed by MLKL oligomerization and plasma membrane rupture. Here, we demonstrate that omega-3 polyunsaturated fatty acids DHA/EPA and the proteasome inhibitor bortezomib induce necroptosis in human multiple myeloma (MM) cells in a RIPK3 independent manner. In addition, it seemed to be that phosphorylation of MLKL was not essential for necroptosis induction in MM cells. We show that treatment of MM cells with these cytotoxic compounds induced cleavage of MLKL into a 35 kDa protein. Furthermore, proteolytic cleavage of MLKL was triggered by activated caspase-3/8/10, and mutation of Asp140Ala in MLKL blocked this cleavage. The pan-caspase inhibitor ZVAD-FMK efficiently prevented DHA/EPA and bortezomib induced cell death. In addition, nuclear translocation of total MLKL and the C-terminus were detected in treated MM cells. Collectively, this present study suggests that caspase-mediated necroptosis may occur under (patho)physiological conditions, delineating a novel regulatory mechanism of necroptosis in RIPK3-deficient cancer cells.
Progress of tumor-associated macrophages in the epithelial-mesenchymal transition of tumor
Authors: Li Xiaoxiao , Chen Ling , Peng Xiaobo , Zhan Xianbao
Published: July 2022

As a significant public health problem with high morbidity and mortality worldwide, tumor is one of the major diseases endangering human life. Moreover, metastasis is the most important contributor to the death of tumor patients. Epithelial-mesenchymal transition (EMT) is an essential biological process in developing primary tumors to metastasis. It underlies tumor progression and metastasis by inducing a series of alterations in tumor cells that confer the ability to move and migrate. Tumor-associated macrophages (TAMs) are one of the primary infiltrating immune cells in the tumor microenvironment, and they play an indispensable role in the EMT process of tumor cells by interacting with tumor cells. With the increasing clarity of the relationship between TAMs and EMT and tumor metastasis, targeting TAMs and EMT processes is emerging as a promising target for developing new cancer therapies. Therefore, this paper reviews the recent research progress of tumor-associated macrophages in tumor epithelial-mesenchymal transition and briefly discusses the current anti-tumor therapies targeting TAMs and EMT processes.
Comprehensive analysis of the glutathione S-transferase Mu (GSTM) gene family in ovarian cancer identifies prognostic and expression significance
Authors: Zhang Juan , Li Yan , Zou Juan , Lai Chun-tian , Zeng Tian , Peng Juan , Zou Wen-da , Cao Bei , Liu Dan , Zhu Li-yu , Li Hui , Li Yu-kun
Published: July 2022

Background

Ovarian cancer (OC) is one of the most common types of gynecologic tumor over the world. The Glutathione S-transferase Mu (GSTM) has five members, including GSTM1-5. These GSTMs is involved in cell metabolism and detoxification, but their role in OC remains unknown.

Methods

Data from multiple public databases associated with OC and GSTMs were collected. Expression, prognosis, function enrichment, immune infiltration, stemness index, and drug sensitivity analysis was utilized to identify the roles of GSTMs in OC progression. RT-qPCR analysis confirmed the effect of AICAR, AT-7519, PHA-793887 and PI-103 on the mRNA levels of GSTM3/4.

Results

GSTM1-5 were decreased in OC samples compared to normal ovary samples. GSTM1/5 were positively correlated with OC prognosis, but GSTM3 was negatively correlated with OC prognosis. Function enrichment analysis indicated GSTMs were involved in glutathione metabolism, drug metabolism, and drug resistance. Immune infiltration analysis indicated GSTM2/3/4 promoted immune escape in OC. GSTM5 was significantly correlated with OC stemness index. GSTM3/4 were remarkedly associated with OC chemoresistance, especially in AICAR, AT-7519, PHA-793887 and PI-103.

Conclusion

GSTM3 was negatively correlated with OC prognosis, and associated with OC chemoresistance and immune escape. This gene may serve as potential prognostic biomarkers and therapeutic target for OC patients.
Emerging Evidence for Intrathecal Management of Neuropathic Pain Following Spinal Cord Injury
Authors: Karri Jay , Doan James , Vangeison Christian , Catalanotto Marissa , Nagpal Ameet S. , Li Sheng
Published: July 2022

A high prevalence of patients with spinal cord injury (SCI) suffer from chronic neuropathic pain. Unfortunately, the precise pathophysiological mechanisms underlying this phenomenon have yet to be clearly elucidated and targeted treatments are largely lacking. As an unfortunate consequence, neuropathic pain in the population with SCI is refractory to standard of care treatments and represents a significant contributor to morbidity and suffering. In recent years, advances from SCI-specific animal studies and translational models have furthered our understanding of the neuronal excitability, glial dysregulation, and chronic inflammation processes that facilitate neuropathic pain. These developments have served advantageously to facilitate exploration into the use of neuromodulation as a treatment modality. The use of intrathecal drug delivery (IDD), with novel pharmacotherapies, to treat chronic neuropathic pain has gained particular attention in both pre-clinical and clinical contexts. In this evidence-based narrative review, we provide a comprehensive exploration into the emerging evidence for the pathogenesis of neuropathic pain following SCI, the evidence basis for IDD as a therapeutic strategy, and novel pharmacologics across impactful animal and clinical studies.
Moderate grade subglottic stenosis in children: Laryngotracheal reconstruction versus cricotracheal resection and anastomosis
Authors: Beatrix Christina Kokje Vivianne , Ishii Alessandro , Sandu Kishore
Published: July 2022

Objective

The surgical treatment of choice of pediatric moderate subglottic stenosis (major grade II and minor grade III SGS or 60–80% lumen obstruction) remains controversial. Laryngotracheal reconstruction (LTR) (with anterior ± posterior grafts for airway expansion) and partial crico-tracheal resection (PCTR) are the mainly described open surgical techniques. We reviewed our pediatric cases with moderate subglottic stenosis to determine the efficacy of LTR versus PCTR.

Methods

A retrospective study of all children between 0 and 18 years that underwent open reconstructive airway surgery between 2012 and 2019. Children who had either acquired or congenital moderate subglottic stenosis (late grade II and early grade III: 60–80% lumen obstruction) were selected.

Results

Twenty-six children with moderate-grade subglottic stenosis were included. Seventeen were treated with LTR and nine with PCTR. No significant differences were observed between LTR and PCTR-treated cases. Decannulation rates were similar, as well as the functional results.

Conclusion

Both LTR and PCTR are valid treatment options for moderate subglottic stenosis. This study indicates to perform the surgery that is most suitable for the characteristics of the patients’ stenosis, the surgeons’ expertise and preference, and the working infrastructure.
Effectiveness of Polidocanol in the Treatment of Venous Malformations: A Meta-Analysis
Authors: Hu Wei , Liu Zhuang , Sun Jiali , Wang Liang , Song Dan , Guo Lei
Published: July 2022

Objective

The aim of this study was to investigate the efficacy of polidocanol against venous malformations (VMs).

Methods

Studies reporting the treatment of VMs using polidocanol (published until February 15, 2020) were reviewed in the Embase and PubMed databases. After excluding the same literature, part of the studies were excluded by reading the title, abstract, full text. Eleven studies (with 287 participants) that fulfilled the inclusion criteria were included. Systematic meta-analysis was performed using Reviews Manager 5.2, and a fixed-effects model was used to calculate the pooled effective rate of polidocanol against VMs and the 95% confidence intervals (CI).

Results

Lesion reduction of more than 50% was considered effective. A total of 287 patients were treated, and treatment in 271 was considered effective. The efficacy of polidocanol was 0.89 (95% CI = 0.83–0.93). Heterogeneity among the studies was small (I2 = 0%, P = 0.47). T The funnel plot was roughly symmetric.

Conclusion

Our study suggested that polidocanol is effective in the treatment of VMs. VMs at different sites can be treated without serious complications. Therefore, we have reason to believe that polidocanol is a safe and an effective drug for VMs.
Abnormal B-Cell Maturation and Increased Transitional B Cells in CBL Syndrome
Authors: Saettini Francesco , Coliva Tiziana Angela , Vendemini Francesca , Galbiati Marta , Bugarin Cristina , Masetti Riccardo , Moratto Daniele , Chiarini Marco , Guerra Fabiola , Iascone Maria , Badolato Raffaele , Cazzaniga Giovanni , Niemeyer Charlotte , Flotho Christian , Biondi Andrea
Published: July 2022

CBL syndrome is a Noonan-like RASopathy with heterogeneous clinical phenotype and predisposition to juvenile myelomonocytic leukemia (JMML). Here we describe two patients with identical germline CBL mutation and clinical and immune-hematological overlapping features with autoimmune lymphoproliferative syndrome (ALPS) and B-cell expansion with NF-κB and T-cell anergy (BENTA) syndrome. Increased immature/transitional B cells can be depicted in CBL syndrome, ALPS, and BENTA. Nonetheless, our patients here described showed peculiar B-cell phenotype due to increased immature/transitional CD34+ B cells. This feature differentiates CBL syndrome from BENTA, pointing toward an abnormal proliferation of B-cell early precursors.
Case report: Fatal outcome of pyridoxine-dependent epilepsy presenting as respiratory distress followed by a circulatory collapse
Authors: Aquilano Giulia , Linnér Agnes , Ygberg Sofia , Stödberg Tommy , Henckel Ewa
Published: July 2022

Pyridoxine-dependent epilepsy is a rare autosomal recessive disease usually associated with neonatal seizures that do not respond to common antiseizure medications but are controlled by pyridoxine administration. Because the symptoms can mimic common neonatal disorders, the diagnosis can be initially missed or delayed. We report a fatal case of a boy who was initially diagnosed with respiratory distress, birth asphyxia, and persistent pulmonary hypertension and whose condition rapidly deteriorated during the first day of life.
The role of necroptosis in common respiratory diseases in children
Authors: Ning Junjie , Qiao Lina
Published: July 2022

Studies have shown that necroptosis (NEC) relies on a unique gene-regulated molecular pathway to cause cell death. With the development of knockout mouse models and specific molecular inhibitors of necrotic proteins, this cell death pathway has been considered one of the important causes of the pathogenesis of human diseases. In this review, we explored the possible roles and mechanisms of NEC in common respiratory diseases in children, such as acute lung injury, acute respiratory distress syndrome, pulmonary infection, childhood asthma, pulmonary hypertension, etc., in order to provide new ideas for the prevention and treatment of such diseases.
School assets and bullying in Chinese youth: A multiple mediation model of intentional self-regulation and internet gaming disorder
Authors: Gan Xiong , Qin Ke-Nan , Xiang Guo-Xing , Jin Xin , Zhu Cong-Shu
Published: July 2022

Bullying is a severe social problem affecting young people all over the world. Previous studies suggested that engagement in bullying had massive effects on teenagers’ physical and psychological development. It is critical and necessary to investigate the antecedents and underlying mechanisms of this phenomenon among young generations. The present study, based on the positive youth development perspective and the developmental assets theory, attempts to explore the positive factors in the school subsystem that could effectively prevent adolescents from bullying, as well as the multiple mediation effects of intentional self-regulation (ISR) and internet gaming disorder (IGD). In this study, we adopted a two-wave design and recruited a sample of 768 Chinese adolescents using a randomized cluster sampling method in the post-pandemic era. The results revealed that T1 school assets significantly and negatively predicted T2 adolescent bullying. Furthermore, T2 ISR and T2 IGD mediated the association between T1 school assets and T2 bullying separately and sequentially. Overall, school resources play a protective role in adolescent development and could effectively prevent them from negative outcomes. These current findings contribute to the literature by providing a further understanding of the direct and indirect protective effects of school assets on adolescent bullying. Moreover, practitioners could also benefit from these findings in preventing and intervening in bullying in the school subsystem.
Current therapy option for necrotizing enterocolitis: Practicalities and challenge
Authors: Wu Huihuan , Guo Kehang , Zhuo Zewei , Zeng Ruijie , Luo Yujun , Yang Qi , Li Jingwei , Jiang Rui , Huang Zena , Sha Weihong , Chen Hao
Published: July 2022

Necrotizing enterocolitis (NEC) is one of the most prevalent neonatal gastrointestinal disorders. Despite ongoing breakthroughs in its treatment and prevention, the incidence and mortality associated with NEC remain high. New therapeutic approaches, such as breast milk composition administration, stem cell therapy, immunotherapy, and fecal microbiota transplantation (FMT) have recently evolved the prevention and the treatment of NEC. This study investigated the most recent advances in NEC therapeutic approaches and discussed their applicability to bring new insight to NEC treatment.
Clinical characteristics and mortality predictors of patients with cancer hospitalized by COVID-19 in a pediatric third-level referral center
Authors: Hernández-Regino Laura-Monserrat , De Jesús Castillejos-López Manuel , Aquino-Gálvez Arnoldo , Velasco-Hidalgo Liliana , García-Guzmán Alda , Aguilar-Ortiz Marco , Cárdenas-Cardos Rocío , Torres-Espíndola Luz María
Published: July 2022

Background

More than 135 million COVID-19 cases (coronavirus disease 2019) have been reported worldwide until today, with over 2.9 million deaths. Several studies have demonstrated that disease severity is lower in the pediatric population than in adults; however, differences are described in patients with chronic diseases, including oncological patients. Current world literature suggests patients with comorbidities, including cancer, have an increased risk of unfortunate outcomes. Therefore, our objective was to describe the clinical characteristics and epidemiological factors associated with mortality in a cohort of pediatric cancer patients hospitalized for COVID-19.

Methods

This is a retrospective, descriptive study of the cases of patients with cancer hospitalized for COVID-19. A total of 40 pediatrics were included in the analysis. Data from pediatric patients with COVID-19 included clinical and epidemiological records, laboratory, imaging studies, COVID-19 diagnostic methods, and medical treatment.

Results

Of the 40 pediatric patients admitted with cancer with a confirmed diagnosis of COVID-19, 42.5% were solid tumors, 40% leukemias, and 17.5% lymphomas. The clinical parameters associated with mortality were stage IV tumor (p = 0.029) and intubation (p < 0.001). The biochemical factors associated with lower survival were thrombocytopenia under 25,000 cells/mm3 (p < 0.001), D-dimer over 1 μg/ml (p = 0.003), clinical malnutrition (p = 0.023), and disseminated intravascular coagulation (p = 0.03).

Conclusion

Our findings showed that the fever was the most frequent symptom, and the clinical parameters associated with mortality were stage IV tumor, intubation, saturation percentage, RDW, platelets, creatinine, ALT, D-dimer, ferritin, and FiO2 percentage. The thrombocytopenia, D-dimer, nutritional status, and disseminated intravascular coagulation were significantly associated with lower survival.
COVID Academic Pandemic: Techno Stress Faced by Teaching Staff for Online Academic Activities
Authors: Zheng Mao , Asif Muhammad , Tufail Muhammad Shahid , Naseer Saira , Khokhar Shahid Ghafoor , Chen Xiding , Naveed Rana Tahir
Published: July 2022

This paper analyzes the impact of the COVID-19 pandemic on the mental health of the teachers, specifically the techno stress arising in them as a result of issues faced by them in the use of technology when they conduct the online academic activities. It aims to assess the major factors related to the online teaching that specifically adds to techno stress on the teachers during the COVID-19 outbreak. Finally, the study aims to provide suggestions to the policymakers and the management of the universities so that the effect of the COVID-19's on teachers' mental health and the related techno stress can be reduced. This paper is a literature review of the articles on the notion of techno stress on teachers and their mental health by searching the related articles with these terminologies using the renowned search engines of Google Scholar and Web of Science. A combination of the terms such as Coronavirus, COVID-19, mental health, psychological distress, techno stress, and online teaching were used in the article search for the review. The literature has suggested that the COVID-19 outbreak has significantly affected the mental health of the employees in general and specifically, the teachers who are engaged in online academic activities and teaching in the universities. The paper has identified a few factors that are the cause of the techno stress and provides recommendations for the university management and the policy makers for minimizing their negative impact on the teachers, in terms of the techno stress and their mental health. Coronavirus is a new strain of the viruses that has badly engulfed the entire population of the world. It is even now badly rising and causing deaths while this article is in the writing phase. The article has addressed the mental health concerns of the university teachers as they are now working from home using ICT for delivering the lectures and conducting the online teaching and learning activities for the students at their universities. This is a matter of grave importance now and requires immediate attention. Hence, this article broadens the scope of the research on the corona virus and its impact on the university teachers.
The current situation and strategy of Olympic education for primary and secondary school students based on Science- Technology- Engineering- Art- Mathematics education in the context of physical literacy
Authors: Li Jia , Yuan Lei
Published: July 2022

The purpose of this paper is the influence of Science- Technology- Engineering- Art- Mathematics (STEAM) education on the Olympic education of primary and middle school students. The research object is the Beijing Olympic model school. The frame structure and educational concept of STEAM education are studied, and a questionnaire survey on the current situation of Olympic education is conducted. Finally, improvement measures based on the survey results are provided combined with STEAM education, and the teaching effect is analyzed. The results show that after the improvement of the educational model, the student’s mastery of the Olympic knowledge has been greatly improved. The proportion of students who can master all knowledge increases from 5.78 to 8.45%, by 2.67%. The proportion of students with knowledge of most Olympic sports increases from 48.6 to 55.67%, by 7.07%. The proportion of students with little or no knowledge drops to 1.54%. Meanwhile, students are increasingly interested in Olympic events, especially after being inspired by the STEAM education model. The proportion of students who are very concerned about Olympic events has increased by 6.45%. The proportion of students who are more concerned about Olympic events has increased by 5.11%. Thus, the Olympic education work has achieved some results. Students gradually become interested in the Olympic events. They begin to actively pay attention to the Olympic events and learn the Olympic spirit. Then, their physical literacy is improved.
The why of the phenomenal aspect of consciousness: Its main functions and the mechanisms underpinning it
Authors: Marchetti Giorgio
Published: July 2022

What distinguishes conscious information processing from other kinds of information processing is its phenomenal aspect (PAC), the-what-it-is-like for an agent to experience something. The PAC supplies the agent with a sense of self, and informs the agent on how its self is affected by the agent’s own operations. The PAC originates from the activity that attention performs to detect the state of what I define “the self” (S). S is centered and develops on a hierarchy of innate and acquired values, and is primarily expressed via the central and peripheral nervous systems; it maps the agent’s body and cognitive capacities, and its interactions with the environment. The detection of the state of S by attention modulates the energy level of the organ of attention (OA), i.e., the neural substrate that underpins attention. This modulation generates the PAC. The PAC can be qualified according to five dimensions: qualitative, quantitative, hedonic, temporal and spatial. Each dimension can be traced back to a specific feature of the modulation of the energy level of the OA.
Teacher cognition in teaching intercultural communicative competence: A qualitative study on preservice Chinese language teachers in Hong Kong SAR, China
Authors: Gong Yang Frank , Lai Chun , Gao Xuesong (Andy) , Li Guofang , Huang Yingxue , Lin Lin
Published: July 2022

The purpose of this study is to examine preservice Chinese language teachers’ cognition in teaching intercultural communicative competence. In the study we collected data through in-depth interviews with seven preservice teachers in a Master of Education program (Teaching Chinese as a Second Language, TCSL) at a university in Hong Kong SAR, China. The findings indicated that the participants had a relatively positive attitude and inclination toward the development of students’ intercultural communicative competence, while their conceptualizations of culture tended to be static and ambiguous. In addition, the participants’ objectives in teaching intercultural communicative competence were found to be more attitude-than knowledge- or skill-oriented. The study offers valuable insights that preservice language teachers’ cognition plays a crucial role in their future professional development and calls for curricular innovations with intercultural aims in teacher education programs.
Impact of knowledge management capabilities on new product development performance through mediating role of organizational agility and moderating role of business model innovation
Authors: Idrees Hisham , Hynek Josef , Xu Jin , Akbar Ahsan , Jabeen Samrena
Published: July 2022

In several studies, knowledge is witnessed as one of the foundations of long-term competitive edge and is also a basic source of new product development (NDP) performance. The aim of this study is to investigate the role of knowledge management capabilities (KMC) in new product development performance with the mediating role of organizational agility. Additionally, this study also intends to examine the moderating role of business model innovation on the relationship of KMC with organizational agility. This study was conducted on the Chinese automobile sector, and the NPD project managers, supervisors, and engineers of the sector were respondents of this study. A survey questionnaire was used to collect the data from 201 respondents, and data were analyzed using the Smart PLS 3 software. The findings of this research, although limited to the automobile industries, indicate that knowledge sharing and knowledge application have significant and positive effects on the development of new products. Organizational agility significantly mediates the relationship of KMC with NPD. The results found that business model innovation has a significant moderating role in the relationship between KMC and organizational agility. Moreover, the results of this study will assist the managers in developing a modern competitive business environment by implicating KMC in the process of NPD. Lastly, organizations may improve the sustainability of their product and their overall performance by using organizational agility and modern ways of value delivery.
How does capability reconfiguration impact the innovation performance of Chinese manufacturing firms?
Authors: Hu Pan , Hao Yanzhi , Wang Gangyi
Published: July 2022

This study explores the relationship between capability reconfiguration and firm innovation performance by analyzing a sample of 375 manufacturing firms in China. The results suggest that the relationship between capability reconfiguration and innovation performance is affected by both the catch-up stage and the mode of capability reconfiguration (evolution or substitution). The catch-up stage of enterprises significantly impacts the moderating effects of innovation magnitude on the relationship between capability substitution and firm innovation performance, however, it has no obvious effects on the moderation of innovation magnitude on the relationship between capability evolution and innovation performance. This study contributes to the theory of dynamic capability and catch-up by revealing how innovation magnitude affects capability reconfiguration and subsequent innovation performance in different catch-up stages. The implication of this study is to remind managers to take full account of the innovation magnitude and catch-up stage in their decision-making.
The changing faces of autism: The fluctuating international diagnostic criteria and the resulting inclusion and exclusion—A Norwegian perspective
Authors: Chahboun Sobh , Stenseng Frode , Page Alexander G.
Published: July 2022

The common understanding of autism spectrum disorders (ASD) has gone through a number of permutations since the first description in 1943. Throughout these shifting understandings, there have been a number of behaviors and diagnostic criteria associated with the condition, many of which are missing in the most recent classifications. The rates of diagnoses of autism have increased greatly. However, there is no reason to think there has been any change in occurrence over the last 70 years, suggesting rather an increase in our knowledge and awareness. Autism has been the subject of several misapprehensions and misrepresentations throughout history. This might be due to heterogeneity of the cases. In addition, the diagnosing of autism spectrum disorders is mainly based on observation and behavioral interpretation, and thus dependent on subjective perceptions of the clinicians themselves. This current scoping review article intends to provide a view on the evolution of the concept of autism and the current stance within Norwegian scholarship, and how it is shaped by international discourses and cultural diversities Such changing concepts especially impacts people with the diagnosis, as it can affect their access to social services, as well as their self-identification as people with ASD.
Search term “One Health” remains of limited use to identify relevant scientific publications: Denmark as a case study
Authors: Benedetti Guido , Jokelainen Pikka , Ethelberg Steen
Published: July 2022

One Health has become a popular approach, and scientific advancements in the field should be easily findable and accessible to a wide range of relevant audiences, from researchers to policymakers, and across sectors. We conducted a systematic narrative review of available scientific publications concerning One Health in the setting of Denmark that were retrievable using “One Health” as the key search term. Three searches in two databases yielded 30 retrieved publications, 13 of which were included in the review. The included publications had been published between 2015 and 2021. Twelve of the included publications were co-authored in collaboration across institutes from different sectors. Three of the included publications had focus on antimicrobial resistance, three on disease surveillance and/or control, and five were assessments or evaluations. The overall number of publications identified by a search using “One Health” as the key search term was small, and the search identified some publications that were not relevant to One Health. Our work thus highlights a missed scientific and communication opportunity of signposting articles as relevant to One Health. Using the expression “One Health” as keyword could help making One Health research more easily findable and thereby obtaining an overview of research in the field.
Epidemiology of malaria and anemia in high and low malaria-endemic North-Eastern districts of India
Authors: Shankar Hari , Singh Mrigendra Pal , Hussain Syed Shah Areeb , Phookan Sobhan , Singh Kuldeep , Mishra Neelima
Published: July 2022

Anemia and malaria are the two major public health problems that lead to substantial morbidity and mortality. Malaria infection destroys erythrocytes, resulting in low hemoglobin (Hb) levels known as anemia. Here we report the determinants of anemia in high and low malaria-endemic areas that would help understand which parasite densities, age, and gender-associated low Hb levels. Therefore, a cross-sectional mass survey (n = 8,233) was conducted to screen anemia and malaria in high and low malaria-endemic districts (HMED and LMED) of North-East India. Axillary body temperature was measured using a digital thermometer. The prevalence of anemia was found to be 55.3% (4,547/8,233), of which 45.1% had mild (2,049/4,547), 52.1% moderate (2,367/4,547) and 2.9% had severe anemia (131/4,547). Among anemic, 70.8% (3,219/4,547) resided in LMED and the rest in HMED. The median age of the anemic population was 12 years (IQR: 7–30). Overall, malaria positivity was 8.9% (734/8,233), of which HMED shared 79.6% (584/734) and LMED 20.4% (150/734) malaria burden. The village-wise malaria frequency was concordant to asymptomatic malaria (10–20%), which showed that apparently all of the malaria cases were asymptomatic in HMED. LMED population had significantly lower Hb than HMED [standardized beta (β) = −0.067, p < 0.0001] and low-density Plasmodium infections had higher Hb levels than high-density infections (β = 0.113; p = 0.031). Women of reproductive age had higher odds for malaria (OR: 1.42; 95% CI: 1.00–2.05; p = 0.04). Females (β = −0.193; p < 0.0001) and febrile individuals (β = −0.029; p = 0.008) have shown lower Hb levels, but malaria positivity did not show any effect on Hb. Young children and women of reproductive age are prone to anemia and malaria. Although there was no relation between malaria with the occurrence of anemia, we found low-density Plasmodium infections, female gender, and LMED were potential determinants of Hb.
Challenges in Understanding the Variability of the Cryosphere in the Himalaya and Its Impact on Regional Water Resources
Authors: Vishwakarma Bramha Dutt , Ramsankaran RAAJ , Azam Mohd. Farooq , Bolch Tobias , Mandal Arindan , Srivastava Smriti , Kumar Pankaj , Sahu Rakesh , Navinkumar Perumal Jayaraman , Tanniru Srinivasa Rao , Javed Aaquib , Soheb Mohd , Dimri A. P. , Yadav Mohit , Devaraju Balaji , Chinnasamy Pennan , Reddy Manne Janga , Murugesan Geetha Priya , Arora Manohar , Jain Sharad K. , Ojha C. S. P. , Harrison Stephan , Bamber Jonathan
Published: July 2022

The Himalaya plays a vital role in regulating the freshwater availability for nearly a billion people living in the Indus, Ganga, and Brahmaputra River basins. Due to climate change and constantly evolving human-hydrosphere interactions, including land use/cover changes, groundwater extraction, reservoir or dam construction, water availability has undergone significant change, and is expected to change further in the future. Therefore, understanding the spatiotemporal evolution of the hydrological cycle over the Himalaya and its river basins has been one of the most critical exercises toward ensuring regional water security. However, due to the lack of extensivein-situmeasurements, complex hydro-climatic environment, and limited collaborative efforts, large gaps in our understanding exist. Moreover, there are several significant issues with available studies, such as lack of consistent hydro-meteorological datasets, very few attempts at integrating different data types, limited spatiotemporal sampling of hydro-meteorological measurements, lack of open access toin-situdatasets, poorly accounted anthropogenic climate feedbacks, and limited understanding of the hydro-meteorological drivers over the region. These factors result in large uncertainties in our estimates of current and future water availability over the Himalaya, which constraints the development of sustainable water management strategies for its river catchments hampering our preparedness for the current and future changes in hydro-climate. To address these issues, a partnership development workshop entitled “Water sEcurity assessment in rIvers oriGinating from Himalaya (WEIGH),” was conducted between the 07th and 11th September 2020. Based on the intense discussions and deliberations among the participants, the most important and urgent research questions were identified. This white paper synthesizes the current understanding, highlights, and the most significant research gaps and research priorities for studying water availability in the Himalaya.
Savvy and woke: Gender, digital profile, social media competence, and political participation in gender issues among young Filipino netizens
Authors: Dayrit Julienne Celina Sicat , Albao Blulean Terosa , Cleofas Jerome Visperas
Published: July 2022

Social media has become a viable platform for political participation in issues related to gender, especially among the youth. Evidence suggests that gender and sexual identities, digital access, and skills foster political participation in social media. This study sought to determine the predictive relationship of gender, digital profile, and social media competence with social media political participation in gender issues (SMPP-GI) among young Filipino netizens through the lenses of social identity theory and resource model of political participation. A total of 1,090 college netizens aged 18–30 years old participated in this cross-sectional study. An online survey was used to collect data. The respondents reported low to moderate levels of SMPP-GI. Females and non-cisheterosexual respondents report higher scores in certain types of SMPP-GI. Respondents using more social media sites have higher levels of latent and counter engagement SMPP-GI. Among the four domains of social media competence, content generation significantly predicted all types of SMPP-GI, while content interpretation and anticipatory reflection were significantly linked with at least one type of engagement.
Social impact projections for Qatar youth residents from 2022: The case of the IAAF 2019
Authors: Ishac Wadih , Swart Kamilla
Published: July 2022

While sport is playing an increasingly important role in society in the Middle East, there has been limited research on the perceived social impact of the hosting of major international events in this region. This study evaluates the main factors affecting youth residents' perceptions of hosting major international sport events, by measuring the psychic income in particular, generated within subgroups shaping their support toward hosting these events. Psychic income refers to the emotional and psychological benefit residents perceive they receive from hosting an international sport event. The study is of significance within the context of residents' perceptions studies given that the large majority of residents in Qatar are non-Qataris. Furthermore, the youth were the target population for this study given that they have been identified as the custodians of the next generation and as an essential force in molding national development; and extends the few residents' perception studies in Qatar which comprised the general population. Using the 2019 IAAF Athletics World championships as an example, a framework by Kim and Walker was adopted. Data were collected from 316 university students' from different nationalities residing in Qatar; a month after the event took place. After conducting confirmatory factor analysis, this study was subject to structural equation modeling. Overall, the results show that the perceived impact on Qatari youth nationals was higher compared to Arab youth, and non-Arab youth, respectively. Likewise, the perceived impact was higher for females compared to males. By evaluating the psychic income received by youth from different nationalities residing in Qatar, this study provides decision-makers and organizers with a better understanding of the outcome generated from hosting major international sport events, and how they can leverage these going forward. Of importance is that even if youth residents do not attend the event in person, these events may still generate positive psychic income which is particular relevant to the 2022 FIFA World Cup given the limitations related to purchasing tickets. With Qatar establishing itself as a regional sport hub by attracting a diverse range of international sport events, a cumulative approach to understanding psychic income is recommended.
Strategies for intraoperative management of the trigeminal nerve and long-term follow-up outcomes in patients with trigeminal neuralgia secondary to an intracranial epidermoid cyst
Authors: Zhang Zhenyu , Wang Wenhua , Yu Feng , Kwok Sze Chai , Wang Yuhai , Yin Jia
Published: July 2022

Background

Epidermoid cysts (ECs) are one of the most common causes of secondary trigeminal neuralgia (TGN). However, most previous studies have primarily focused on whether complete tumor resection was achieved, and few studies have discussed the primary goal of pain relief.

Objective

The present study provides intraoperative strategies for trigeminal nerve (TN) management in patients with TGN secondary to an EC and observed long-term follow-up outcomes.

Methods

A total of 69 patients with TGN secondary to an EC at our hospitals were included (January 2011–June 2021). The same surgical team performed all surgeries using a retrosigmoid approach. After EC removal, different methods for TN management were used, including microvascular decompression (MVD), sharp capsulectomy, nerve combing and embedded cholesterol crystal excision. The epidemiological, clinical, and surgical data were extracted.

Results

The total EC removal rate was 92.8% (64/69). All patients achieved initial pain relief postoperatively, and 12 patients (17.4%) experienced varying degrees of hemifacial hypesthesia, which was relieved within 3–6 months. Three patients (4.3%) reported partial pain recurrence within a median follow-up period of 5.5 (0.5–10.5) years, which was relieved completely after low-dose carbamazepine administration.

Conclusion

The primary goal of surgical tumor removal for patients with TGN secondary to an EC is relief of the main symptom of tormenting pain. The selection of an appropriate strategy for TN, including MVD, sharp capsulectomy, nerve combing or embedded cholesterol crystal excision, should depend on the patient's situation.
The anatomical relationship between the mandibular first molar roots and the mandibular canal based on breed size and skull type
Authors: Greene Erica , Rendahl Aaron , Goldschmidt Stephanie
Published: July 2022

The first molar is the largest tooth in the dog mandible with roots often extending to the level of the mandibular canal (MC). The anatomical relationship between the roots and MC is variable and the normal relationship between those structures in a diverse population of dogs has not been established. The lingual location of the roots relative to the MC poses a risk for iatrogenic trauma during dentoalveolar surgery, and it is unknown if certain skull conformations are predisposed to this relationship. This study aimed to identify associations between patient weight and skull type with molar tooth root location. CT scans performed for reasons unrelated to the study were retrospectively analyzed. Subjects were sorted into one of 12 groups (n=16 per group) based on skull type (brachycephalic, mesaticephalic, and dolichocephalic) and weight (extra small: ≤ 6.8 kg, small: >6.8 to ≤ 13.6 kg, medium: >13.6 to ≤ 25 kg, and large >25 to ≤ 38.6 kg). The mandibular first molar roots were categorized as lingual, buccal, or dorsal relative to the MC. Lingual root location was diagnosed in 50.0% of all roots evaluated, and 64.2% of all dogs assessed had at least one root in the lingual position. The size was shown to be protective, with lingual root location being significantly less likely as size increased. The exception to this was in large brachycephalic patients, which had rates of lingual roots similar to smaller dogs. Buccal roots were rarest, diagnosed in only 9.7% of all roots, and were most common in brachycephalic patients, which had 83.8% of all buccal roots. Additional caution should be employed when removing alveolar bone during surgical extraction in dogs ≤ 13.6 kg and in large brachycephalic patients (boxers) to avoid iatrogenic trauma to the neurovascular bundle.