Sleep structure in adults with recurrent epileptic seizures of remote symptomatic etiology
Authors:   PhD, Associate Professor of the Department of Neurology and Neurosurgery of the Federal State Budgetary Educational Institution of Higher Professional Education “Siberian State Medical University” of the Ministry of Health of the Russian Federation, Grebenyuk O.V. , Kazennykh T.V. ,   MD, Deputy Director for Scientific and Medical Work of Mental Health Research Institute of Tomsk National Research Medical Center, Professor of the Department of Psychiatry, Narcology and Psychotherapy of the Federal State Budgetary Educational Institution of Higher Professional Education Siberian State Medical University MH RF, Svetlik M.V. ,   PhD, Associate Professor of the Department of Human and Animal Physiology of the Biological Institute of the Federal State Autonomous Educational Institution of Higher Education National Research Tomsk State University, Pugachenko N.V. ,   Associate Professor of the Department of Neurology and Neurosurgery of the Federal State Budgetary Educational Institution of Higher Professional Education Siberian State Medical University of the Ministry of Health of the Russian Federation, Cand.Sc. (Medicine), Avkhimenko V.A. ,   PhD, General Director of the Federal State Budgetary Institution of the Siberian Federal Scientific and Clinical Center of the Federal Medical and Biological Agency of Russia, Levko A.N. ,   PhD, Vice-Rector for Interaction with Regions of the Federal State Budgetary Educational Institution of Higher Professional Education Siberian State Medical University of the Ministry of Health of the Russian Federation, Alifirova V.M. ,   MD, Head of the Department of Neurology and Neurosurgery of the Federal State Budgetary Educational Institution of Higher Professional Education Siberian State Medical University of the Ministry of Health of the Russian Federation, Professor, Bohan N.A. ,   MD, Director of Mental Health Research Institute of Tomsk National Research Medical Center, psychiatrist of the highest category,  Professor, academician of the Russian Academy of Sciences, Honored Scientist of the Russian Federation, Head of the Department of Psychiatry, Narcology and Psychotherapy of the Federal State Budgetary Educational Institution of Higher Professional Education Siberian State Medical University of the Ministry of Health of the Russian Federation
Published: January 2025

A video-polysomnographic study of the structural characteristics of night sleep was carried out in 157 patients with a first-time unprovoked tonic-clonic seizure. The main group included patients with remote symptomatic seizure (RSS). Over the course of three years, 60 individuals had recurrent attacks; 38 patients had no recurrence of attacks during the observation period. The comparison group included 59 MRI- and EEG-negative patients. Patients with recurrent RSS had lower sleep efficiency, longer rapid eye movement phase, sleep fragmentation, wake after sleep onset, and more frequent awakenings from sleep (number of awakenings) versus patients with a single RSS and the comparison group. The identified changes demonstrate deeper disturbances in sleep architecture in patients with recurrent RSS and can be taken into account in prognostic counseling of this category of patients.
Keywords: remote symptomatic seizure, sleep structure.