bluuebunny/crossref_metadata_2025 huggingface dataset:
An integrated approach reveals how lipo‐chitooligosaccharides interact with the lysin motif receptor‐like kinase MtLYR3
Authors: Bouchiba Younes , Esque Jérémy , Cottret Ludovic , Maréchaux Maude , Gaston Mégane , Gasciolli Virginie , Keller Jean , Nouwen Nico , Gully Djamel , Arrighi Jean‐François , Gough Clare , Lefebvre Benoit , Barbe Sophie , Bono Jean‐Jacques
Published: May 2022

N‐acetylglucosamine containing compounds acting as pathogenic or symbiotic signals are perceived by plant‐specific Lysin Motif Receptor‐Like Kinases (LysM‐RLKs). The molecular mechanisms of this perception are not fully understood, notably those of lipo‐chitooligosaccharides (LCOs) produced during root endosymbioses with nitrogen‐fixing bacteria or arbuscular mycorrhizal fungi. In Medicago truncatula, we previously identified the LysM‐RLK LYR3 (MtLYR3) as a specific LCO‐binding protein. We also showed that the absence of LCO binding to LYR3 of the non‐mycorrhizal Lupinus angustifolius, (LanLYR3), was related to LysM3, which differs from that of MtLYR3 by several amino acids and, particularly, by a critical tyrosine residue absent in LanLYR3. Here, we aimed to define the LCO binding site of MtLYR3 by using molecular modelling and simulation approaches, combined with site‐directed mutagenesis and LCO binding experiments. 3D models of MtLYR3 and LanLYR3 ectodomains were built, and homology modelling and molecular dynamics (MD) simulations were performed. Molecular docking and MD simulation on the LysM3 identified potential key residues for LCO binding. We highlighted by steered MD simulations that in addition to the critical tyrosine, two other residues were important for LCO binding in MtLYR3. Substitution of these residues in LanLYR3‐LysM3 by those of MtLYR3‐LysM3 allowed the recovery of high‐affinity LCO binding in experimental radioligand‐binding assays. An analysis of selective constraints revealed that the critical tyrosine has experienced positive selection pressure and is absent in some LYR3 proteins. These findings now pave the way to uncover the functional significance of this specific evolutionary pattern.
Phytochemistry, synthesis, analytical methods, pharmacological activity, and pharmacokinetics of loganin: A comprehensive review
Authors: Zhang Fan , Yan Yu , Zhang Jia , Li Li , Wang Yu‐Wei , Xia Cong‐Yuan , Lian Wen‐Wen , Peng Ying , Zheng Jiang , He Jun , Xu Jie‐Kun , Zhang Wei‐Ku
Published: May 2022

Iridoid glycosides (IGs) are found in many medicinal and edible plants, such as Gardenia jasminoides, Cistanche tubulosa, Eucommia ulmoides, Rehmanniae Radix, Lonicera japonica, and Cornus officinalis. Loganin, an IG, is one of the main active ingredient of Cornus officinalis Sieb. et Zucc., which approved as a medicinal and edible plant in China. Loganin has been widely concerned due to its extensive pharmacological effects, including anti‐diabetic, antiinflammatory, neuroprotective, and anti‐tumor activities, etc. Studies have shown that these underlying mechanisms include anti‐oxidation, antiinflammation and anti‐apoptosis by regulating a variety of signaling pathways, such as STAT3/NF‐κB, JAK/STAT3, TLR4/NF‐κB, PI3K/Akt, MCP‐1/CCR2, and RAGE/Nox4/p65 NF‐κB signaling pathways. In order to better understand the research status of loganin and promote its application in human health, this paper systematically summarized the phytochemistry, analysis methods, synthesis, pharmacological properties and related mechanisms, and pharmacokinetics based on the research in the past decades.
The stability investigation of variable viscosity control in the human‐robot interaction
Authors: Dong Lin , Perrin Nicolas , Richer Florian , Roby‐Brami Agnes , Morel Guillaume
Published: May 2022

Background

For many co‐manipulative applications, variable damping is a valuable feature provided by robots. One approach is implementing a high viscosity at low velocities and a low viscosity at high velocities. This, however, is proven to have the possibility to alter human natural motion performance.

Methods

We show that the distortion is caused by the viscosity drop resulting in robot's resistance to motion. To address this, a method for stably achieving the desired behaviour is presented. It involves leveraging a first‐order linear filter to slow the viscosity variation down.

Results

The proposition is supported by a theoretical analysis using a robotic model. Meanwhile, the user performance in human‐robot experiments gets significantly improved, showing the practical efficiency in real applications.

Conclusions

This paper discusses the variable viscosity control in the context of co‐manipulation. An instability problem and its solution were theoretically shown and experimentally evidenced through human‐robot experiments.
Helium behavior and vacancy‐defect evolution in nickel‐base alloy by helium ion beam irradiation and annealing
Authors: Lv Shasha , Zhu Rui , Shen Yuanhua , Zhou Qin , Shi Li , Sun Libin , Wu Xinxin , Li Zhengcao
Published: May 2022

Nickel‐base alloys have been selected as a potential metallic material for reactor internals in Generation IV reactors. In order to evaluate their helium embrittlement resistance, microstrain changes and evolution of vacancy‐type defects after Helium irradiation and postimplantation annealing have been studied by grazing incidence X‐ray diffraction (GIXRD) and slow positron doppler broadening spectroscopy (PDB). GIXRD results show that the increase in microstrain after helium irradiation is more pronounced at high doses. The observed S parameters of PDB increase with the irradiation doses, which indicates a significant number of vacancy‐type defects, possibly helium‐vacancy clusters. For postimplantation annealing specimens, the microstrain characterized by GIXRD has recovered. The surprise is the S parameters that significantly increase, revealing that helium atoms trapped at unstable helium‐vacancy clusters desorb during annealing, contributing to the growth of helium bubbles. These findings of microstrain mechanisms and vacancy‐type defects behaviors give us new insights into the helium irradiation evaluation.
Modeling the underlying biological processes in Alzheimer's disease using a multivariate competing risk joint model
Authors: van Oudenhoven Floor M. , Swinkels Sophie H. N. , Hartmann Tobias , Rizopoulos Dimitris
Published: May 2022

Many clinical trials repeatedly measure several longitudinal outcomes on patients. Patient follow‐up can discontinue due to an outcome‐dependent event, such as clinical diagnosis, death, or dropout. Joint modeling is a popular choice for the analysis of this type of data. Using example data from a prodromal Alzheimer's disease trial, we propose a new type of multivariate joint model in which longitudinal brain imaging outcomes and memory impairment ratings are allowed to be associated both with time to open‐label medication and dropout, and where the brain imaging outcomes may also directly affect the memory impairment ratings. Existing joint models for multivariate longitudinal outcomes account for the correlation between the longitudinal outcomes through the random effects, often by assuming a multivariate normal distribution. However, for these models, it is difficult to interpret how the longitudinal outcomes affect each other. We model the dependence between the longitudinal outcomes differently so that a first longitudinal outcome affects a second one. Specifically, for each longitudinal outcome, we use a linear mixed‐effects model to estimate its trajectory, where, for the second longitudinal outcome, we include the linear predictor of the first outcome as a time‐varying covariate. This facilitates an easy and direct interpretation of the association between the longitudinal outcomes and provides a framework for latent mediation analysis to understand the underlying biological processes. For the trial considered here, we found that part of the intervention effect is mediated through hippocampal brain atrophy. The proposed joint models are fitted using a Bayesian framework via MCMC simulation.
Perturbed potential temperature field in the atmospheric boundary layer
Authors: Karjanto Natanael
Published: May 2022

This article discusses the modeling of perturbed potential temperature field in an atmospheric boundary layer (ABL). We adopt a convection–diffusion model with specified initial and boundary conditions that resulted from simplifying the linearized equation of the standard continuity equation for potential temperature field in the state of weak turbulent fluxes. By implementing the method of separation of variables to the nonsteady‐state perturbed potential temperature, we obtain a regular Sturm–Liouville boundary value problem (BVP) for the spatial‐dependent, vertical distribution component of the perturbed potential temperature. By transforming the problem in the canonical form into the Liouville normal form, we provide asymptotic solutions for the corresponding second‐order BVP using the Wentzel–Kramers–Brillouin (WKB) theory. We further observe a remarkable qualitative agreement between the asymptotic solutions and numerical simulations. As other convection–diffusion models typically perform, the perturbed potential temperature diminishes and approaches the steady‐state condition over an extended period of time.
Quality assurance systems for Digital Higher Education in Europe
Authors: Ubachs George , Henderikx Piet
Published: May 2022

Since the corona crisis, digital higher education practices permeate higher education in Europe. In degree education, various digital pedagogies are used in courses and programs, such as synchronous hybrid, blended, and online education and distance learning. In addition to degree education, higher education institutions offer online continuing education and open education through MOOCs. Microcredentials are high on the agenda of the European Commission, national governments, and institutions.

The international dimension has also become important in all these areas. Universities organize joint curricula and virtual mobility schemes. This development has even been reinforced by the European Universities Initiatives of the European Commission (EUI), which already created 41 university alliances across Europe.

Digital education plays a vital role in creating a new pedagogical landscape shaping the Commission’s Transformation of the European University 2030. This has implications for the internal and external quality assurance of education, which should lead to better quality and more robust maturity.

This chapter illustrates how quality assurance models and practices in Europe have evolved towards a multilevel and multi-stakeholder approach. It describes the development of quality assurance systems and guidelines for digital higher education in Europe in recent decades. In addition, it focuses on new quality assurance challenges to respond to the next stages of development in higher education, keeping pace with future innovations. Finally, it provides an overview of the current position of quality assurance with the most important conclusions.
SIRT7 in the aging process
Authors: Lagunas-Rangel Francisco Alejandro
Published: May 2022

Aging is the result of the accumulation of a wide variety of molecular and cellular damage over time. This has been associated with a number of features termed hallmarks of aging, including genomic instability, loss of proteostasis, telomere attrition, dysregulated nutrient sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, and impaired intercellular communication. On the other hand, sirtuins are enzymes with an important role in aging and life extension, of which humans have seven paralogs (SIRT1 to SIRT7). SIRT7 is the least studied sirtuin to date, but it has been reported to serve important functions, such as promoting ribosomal RNA expression, aiding in DNA damage repair, and regulating chromatin compaction. Several studies have established a close relationship between SIRT7 and age-related processes, but knowledge in this area is still scarce. Therefore, the purpose of this review was to analyze how SIRT7 is associated with each of the hallmarks of aging, as well as with some of age-associated diseases, such as cardiovascular diseases, obesity, osteoporosis, and cancer.
Analytic Langlands correspondence for $$PGL_2$$ on $${\mathbb {P}}^1$$ with parabolic structures over local fields
Authors: Etingof Pavel , Frenkel Edward , Kazhdan David
Published: May 2022

We continue to develop the analytic Langlands program for curves over local fields initiated in our earlier papers, following a suggestion of Langlands and a work of Teschner. Namely, we study the Hecke operators which we introduced in those papers in the case of a projective line with parabolic structures at finitely many points for the group$$PGL_2$$PGL2. We establish most of our conjectures in this case.
Prevalence of incidental findings in adult vs. adolescent patients in the course of orthodontic X-ray diagnostics
Authors: Klenke Daniela , Santander Petra , Vehring Charlotte , Quast Anja , Sommerlath Sohns Jan , Krohn Sebastian , Meyer-Marcotty Philipp
Published: May 2022

Objective

Due to increasing numbers of adult patients presenting to orthodontic practices, an increase in incidental findings on diagnostic X‑rays, which are the cornerstone of orthodontic diagnostics, is expected. This raises the clinically relevant question of whether an age effect exists regarding prevalence, localisation and severity of incidental findings on orthodontic diagnostic X‑rays.

Materials and methods

The clinical, primarily retrospective study examined pathological incidental findings from 600 orthopantomograms (OPT) and lateral cephalogram (LC) images in two groups of orthodontic patients (group I: 150 children/adolescents, age 11.89 ± 2.47 years; group II: 150 adults, age 27.03 ± 10.42 years). Prevalence, localisation and severity of the findings were recorded based on a classification sheet. The assessment was done by three experienced examiners following a systematic approach along the nine locations: mandible, maxilla, dentition, paranasal sinuses, temporomandibular joint, cranial base, orbit, cervical spine, soft tissues.

Results

In all, 1458 incidental findings were detected, with 66% of the findings having occurred away from the dentition. There was a significant age effect (p < 0.001) with respect to the prevalence of incidental findings (group II—adults 1026 findings—OPT: 566/LC 460 vs. group I—children/adolescents 432 findings—OPT: 221/LC 211). Regarding localisation, incidental findings in adults commonly occurred in the dentition, paranasal sinuses and mandibular regions. Furthermore, analysis of the LC images revealed significantly more incidental findings in the area of the cranial base and cervical spine in adults (p < 0.001, p = 0.003). Categorisation according to the severity of the incidental findings showed that 33% of the incidental findings needed further diagnostic investigation and possibly treatment by other specialities.

Conclusion

Diagnostic assessment using orthodontic diagnostic X‑rays results in a high prevalence of incidental findings away from the dentition. Particularly in adults, a large number of incidental findings outside the dental/alveolar region may be expected on orthodontic diagnostic X‑rays. Thus, a structured approach during diagnostic assessment is required to minimise the extent to which incidental findings of clinical relevance are overlooked.
Controlling local overheating in topology optimization for additive manufacturing
Authors: Ranjan R. , Ayas C. , Langelaar M. , Keulen F. van
Published: May 2022

A novel constraint to prevent local overheating is presented for use in topology optimization (TO). The very basis for the constraint is the Additive Manufacturing (AM) process physics. AM enables fabrication of highly complex topologically optimized designs. However, local overheating is a major concern especially in metal AM processes leading to part failure, poor surface finish, lack of dimensional precision, and inferior mechanical properties. It should therefore be taken into account at the design optimization stage. However, including a detailed process simulation in the optimization would make the optimization intractable. Hence, a computationally inexpensive thermal process model, recently presented in the literature, is used to detect zones prone to local overheating in a given part geometry. The process model is integrated into density-based TO in combination with a robust formulation, and applied in various numerical test examples. It is found that existing AM-oriented TO methods which rely purely on overhang control do not ensure overheating avoidance. Instead, the proposed physics-based constraint is able to suppress geometric features causing local overheating and delivers optimized results in a computationally efficient manner.
High-performance thin-layer chromatography in combination with an acetylcholinesterase-inhibition bioassay with pre-oxidation of organothiophosphates to determine neurotoxic effects in storm, waste, and surface water
Authors: Baetz Nicolai , Schmidt Torsten C. , Tuerk Jochen
Published: May 2022

Pesticides such as organothiophosphates (OTPs) are neurotoxically active and enter the aquatic environment. Bioassays, using acetylcholinesterase (AChE), a suitable substrate and reactant, can be applied for the photometric detection of AChE-inhibiton (AChE-I) effects. The oxidized forms of OTPs, so-called oxons, have higher inhibition potentials for AChE. Therefore, a higher sensitivity is achieved for application of oxidized samples to the AChE assay. In this study, the oxidation of malathion, parathion, and chlorpyrifos by n-bromosuccinimide (NBS) was investigated in an approach combining high-performance thin-layer chromatography (HPTLC) with an AChE-I assay. Two AChE application approaches, immersion and spraying, were compared regarding sensitivity, precision, and general feasibility of the OTP effect detection. The oxidation by NBS led to an activation of the OTPs and a strong increase in sensitivity similar to the oxons tested. The sensitivity and precision of the two application techniques were similar, although the spray method was slightly more sensitive to the oxidized OTPs. The 10% inhibition concentrations (IC10) for the spray approach were 0.26, 0.75, and 0.35 ng/spot for activated malathion, parathion, and chlorpyrifos, respectively. AChE-I effect recoveries in samples from a stormwater retention basin and receiving stream were between 69 and 92% for malathion, parathion, and chlorpyrifos. The overall workflow, including sample enrichment by solid-phase extraction, HPTLC, oxidation of OTPs, and AChE-I assay, was demonstrated to be suitable for the detection of AChE-I effects in native water samples. An effect of unknown origin was found in a sample from a stormwater retention basin.
Blinded by the light: Seabird collision events in South Georgia
Authors: Coleman Jamie , Hollyman Philip R. , Black Andy , Collins Martin A.
Published: May 2022

Light-induced bird strikes on vessels occur frequently in association with areas of high seabird density, often resulting in bird mortalities. These incidents are poorly understood and likely under-reported by vessels. Here we present the details of four separate bird strike events (899, 206, 50 and 47 birds), which took place whilst vessels (two fishing trawlers and one tourist expedition ship) were navigating along the south coast of South Georgia, and discuss possible contributing factors. All species encountered in these events were burrowing petrel species in the family Procellariidae, with diving-petrel species (Pelecanoidesspp.) being most commonly reported. All four events took place during the night in similar meteorological conditions, with poor visibility due to fog, light precipitation and low wind speeds. We identify the waters off the south coast, between King Haakon Bay and Drygalski Fjord, which have remained rat free and are of exceptional importance to breeding seabirds, as high risk for collisions and propose other high-risk areas. The different mortality rates recorded during these events are likely attributed to the varying actions taken by ship crew and persons on board. We propose actions that will help reduce the occurrence of events and mitigate the impact of bird strikes, including the avoidance of high-risk areas in certain night-time conditions. We give recommendations on what to do when birds land on board and stress the importance of reporting of events. Given the expected increase of both fishing and tourist ship activity in South Georgia waters, there is an increasing need to understand and mitigate this threat to seabirds.
Diffusion chronometry of volcanic rocks: looking backward and forward
Authors: Chakraborty Sumit , Dohmen Ralf
Published: May 2022

Diffusion of elements that result in compositional zoning in minerals in volcanic rocks may be used to determine the timescales of various volcanic processes (e.g., residence times in different reservoirs, ascent rates of magmas). Here, we introduce the tool and discuss the reasons for its gain in popularity in recent times, followed by a summary of various applications and some main inferences from those applications. Some specialized topics that include the role of diffusion anisotropy, isotopic fractionation by diffusion, image analysis as a tool for expediting applications, and the sources of uncertainties in the method are discussed. We point to the connection between timescales obtained from diffusion chronometry to those obtained from geochronology as well as various monitoring tools. A listing of directions in which we feel most progress is necessary/will be forthcoming is provided in the end.
An ecological momentary assessment study of age effects on perceptive and non-perceptive clinical high-risk symptoms of psychosis
Authors: Michel C. , Lerch S. , Büetiger J. R. , Flückiger R. , Cavelti M. , Koenig J. , Kaess M. , Kindler J.
Published: May 2022

Among individuals with clinical high risk for psychosis (CHR), perceptive symptoms are more frequent but have less clinical significance in children/adolescents compared to adults. However, findings are based on clinical interviews relying on patient’s recall capacity. Ecological momentary assessment (EMA) can be used to explore experiences in real-time in the subject’s daily life. The aim of this study was to assess frequency and stability of (perceptive and non-perceptive) CHR symptoms and to explore potential age effects. EMA was used in a sample of an early detection for psychosis service in Bern, Switzerland (N = 66; 11–36 years). CHR symptoms were recorded in random time intervals for seven days: eight assessments per day per subject, minimum time between prompts set at 25 min. CHR symptoms were additionally assessed with semi-structured interviews including the ‘Structured Interview for Psychosis-Risk Syndromes’ and the ‘Schizophrenia Proneness Instruments’. Mixed-effects linear regression analysis on the frequency of CHR symptoms revealed a significant effect of age group, and the interaction CHR symptoms x age group for both perceptive and non-perceptive symptoms. Further, regarding stability of CHR symptoms, there was a significant effect of the interaction CHR symptoms x age group for perceptive symptoms only. Based on EMA, perceptive CHR symptoms were more frequently reported but less stable in children/adolescents compared with adults. Together with previous findings, our finding of higher instability/variability of perceptive symptoms in younger persons might suggest that with advancing age and more stability of CHR symptoms, clinical relevance (reduced psychosocial functioning) may increase.
The cardiosplenic axis: the prognostic role of the spleen in heart failure
Authors: Hiraiwa Hiroaki , Okumura Takahiro , Murohara Toyoaki
Published: May 2022

Despite the number of available methods to predict prognosis in patients with heart failure, prognosis remains poor, likely because of marked patient heterogeneity and varied heart failure etiologies. Thus, identification of novel prognostic indicators to stratify risk in patients with heart failure is of paramount importance. The spleen is emerging as a potential novel prognostic indicator for heart failure. In this article, we provide an overview of the current prognostic tools used for heart failure. We then introduce the spleen as a potential novel prognostic indicator, before outlining the structure and function of the spleen and introducing the concept of the cardiosplenic axis. This is followed by a focused discussion on the function of the spleen in the immune response and in hemodynamics, as well as a review of what is known about the usefulness of the spleen as an indicator of heart failure. Expert insight into the most effective spleen-related measurement indices for the prognostication of patients with heart failure is provided, and suggestions on how these could be measured in clinical practice are considered. In future, studies in humans will be required to draw definitive links between specific splenic measurements and different heart failure manifestations, as well as to determine whether splenic prognostic measurements differ between heart failure classes and etiologies. These contributions will provide a step forward in our understanding of the usefulness of the spleen as a prognostic predictor in heart failure.
Discontinuation of performance-based financing in primary health care: impact on family planning and maternal and child health
Authors: El-Shal Amira , Cubi-Molla Patricia , Jofre-Bonet Mireia
Published: May 2022

Performance-based financing (PBF) is advocated as an effective means to improve the quality of care by changing healthcare providers’ behavior. However, there is limited evidence on its effectiveness in low- and middle-income countries and on its implementation in primary care settings. Evidence on the effect of discontinuing PBF is even more limited than that of introducing PBF schemes. We estimate the effects of discontinuing PBF in Egypt on family planning, maternal health, and child health outcomes. We use a difference-in-differences (DiD) model with fixed effects, exploiting a unique dataset of six waves of spatially constructed facility-level health outcomes. We find that discontinuing performance-based incentives to providers had a negative effect on the knowledge of contraceptive methods, iron supplementation during pregnancy, the prevalence of childhood acute respiratory infection, and, more importantly, under-five child mortality, all of which were indirectly targeted by the PBF scheme. No significant effects are reported for directly targeted outcomes. Our findings suggest that PBF can induce permanent changes in providers’ behavior, but this may come at the expense of non-contracted outcomes.
Surface Structuring and Reverse Deposition of Nanoporous Titanium Oxides by Laser Ablation of Titanium in Air
Authors: Veiko V. P. , Karlagina Yu Yu , Samokhvalov A. A. , Polyakov D. S. , Manokhin S. S. , Radaev M. M. , Odintsova G. V. , Gornushkin I. B.
Published: May 2022

The deposition of titanium oxides during titanium laser ablation in air has been experimentally and numerically investigated. A titanium sample was irradiated by nanosecond pulses from an Yb-fiber laser with a beam scanned across the sample surface for its texturing. As a result, the hierarchical structure was observed consisting of a microrelief formed by the laser ablation and a nanoporous coating formed by the reverse deposition from the laser induced plasma plume. The chemical and phase composition of the nanoporous coating, as well as the morphology and structure of the surface, were studied using scanning electron microscopy, atomic force microscopy, and X-ray microanalysis. It was found that the deposit consists mostly of porous TiO2with 26% porosity and inclusions of TiO, Ti2O3, and Ti2O3N. Optical emission spectroscopy was used to control the plasma composition and estimate the effective temperature of plasma plume. The chemical-hydrodynamic model of laser induced plasma was developed to get a deeper insight into the deposition process. The model predicts that condensed titanium oxides, formed in peripheral plasma zones, gradually accumulate on the surface during the plasma plume evolution. A satisfactory agreement between the experimental and calculated chemical composition of the plasma plume as well as between the experimental and calculated composition and thickness of the deposited film was demonstrated. This allows a cautious conclusion that the formation of condensed oxides in the plasma and their consequent deposition onto the ablation surface are among the key mechanisms of formation of porous surface films.
Fund manager skill: selling matters more!
Authors: Tosun Onur Kemal , Jin Liang , Taffler Richard , Eshraghi Arman
Published: May 2022

We examine whether mutual fund managers have differential skill in the buy and sell domains. Although they have characteristic-timing ability in aggregate, we show they exhibit asymmetric ability when buying and selling. Our key finding is that fund managers with superior selling ability are significantly better at buying stocks and, as a result, earn significantly higher aggregate returns. However, fund managers who buy stocks successfully do not necessarily have parallel selling skills, leading to lower returns overall. Thus, we provide strong evidence that selling skill is the key determinant of overall mutual fund timing performance.
Procrustes Analysis for High-Dimensional Data
Authors: Andreella Angela , Finos Livio
Published: May 2022

The Procrustes-based perturbation model (Goodall in J R Stat Soc Ser B Methodol 53(2):285–321, 1991) allows minimization of the Frobenius distance between matrices by similarity transformation. However, it suffers from non-identifiability, critical interpretation of the transformed matrices, and inapplicability in high-dimensional data. We provide an extension of the perturbation model focused on the high-dimensional data framework, called the ProMises (Procrustes von Mises–Fisher) model. The ill-posed and interpretability problems are solved by imposing a proper prior distribution for the orthogonal matrix parameter (i.e., the von Mises–Fisher distribution) which is a conjugate prior, resulting in a fast estimation process. Furthermore, we present the Efficient ProMises model for the high-dimensional framework, useful in neuroimaging, where the problem has much more than three dimensions. We found a great improvement in functional magnetic resonance imaging connectivity analysis because the ProMises model permits incorporation of topological brain information in the alignment’s estimation process.
Temperature Dependence of Hall–Petch Parameters Using In Situ Diffraction Experiments in AZ31 Alloy
Authors: Garces G. , Clemente A. , Medina J. , Perez P. , Stark A. , Schell N. , Adeva P.
Published: May 2022

The temperature evolution of the Hall–Petch parameters for basal slip and twinning systems has been evaluated for the AZ31 alloy, using synchrotron radiation diffraction during compression tests from room temperature to 473 K. The AZ31 alloy was processed following two processing routes, casting and powder metallurgy, to obtain two different grain sizes with a similar strong fiber texture. Although macroscopic plasticity is controlled by tensile twinning, the stress for the activation of basal slip can also be calculated. At low temperatures, the grain size dependence of twinning is much higher than that for basal slip. However, basal slip prevails at 473 K, especially for the alloy processed through the powder metallurgy route, because of the low tendency for twinning deformation.
Adrenal crises in adolescents and young adults
Authors: Rushworth R. Louise , Chrisp Georgina L. , Bownes Suzannah , Torpy David J. , Falhammar Henrik
Published: May 2022

Purpose

Review the literature concerning adrenal insufficiency (AI) and adrenal crisis (AC) in adolescents and young adults.

Methods

Searches of PubMed identifying relevant reports up to March 2022.

Results

AI is rare disorder that requires lifelong glucocorticoid replacement therapy and is associated with substantial morbidity and occasional mortality among adolescents and young adults. Aetiologies in this age group are more commonly congenital, with acquired causes, resulting from tumours in the hypothalamic-pituitary area and autoimmune adrenalitis among others, increasing with age. All patients with AI are at risk of AC, which have an estimated incidence of 6 to 8 ACs/100 patient years. Prevention of ACs includes use of educational interventions to achieve competency in dose escalation and parenteral glucocorticoid administration during times of physiological stress, such as an intercurrent infection. While the incidence of AI/AC in young children and adults has been documented, there are few studies focussed on the AC occurrence in adolescents and young adults with AI. This is despite the range of developmental, psychosocial, and structural changes that can interfere with chronic disease management during this important period of growth and development.

Conclusion

In this review, we examine the current state of knowledge of AC epidemiology in emerging adults; examine the causes of ACs in this age group; and suggest areas for further investigation that are aimed at reducing the incidence and health impact of ACs in these patients.
Spontaneous Hind Limb Paralysis Due to Acute Precursor B Cell Leukemia in RAG1-deficient Mice
Authors: Feifei Liu , Richter Anna , Runge Jens , Keiler Jonas , Hermann Andreas , Kipp Markus , Joost Sarah
Published: May 2022

RAG1-deficient mice are a frequently used immunodeficient mouse strain lacking mature lymphocytes. Apart from an elevated risk for infections, no predispositions for diseases of this strain have been described so far. We here report a high incidence of spontaneous pro B cell leukemia resulting in hind limb paralysis in our colony of RAG1-deficient mice. At an age of 7–13 months, animals developed hind limb paralysis and rapid decrease of the overall health condition leading to the need of euthanasia. Histological and flow cytometric analyses as well as micro-computed tomography (micro-CT) scans revealed CD45+ CD19+ IgM− cell infiltrates in the spleen, the bone marrow, and the spinal canal. Monthly blood sampling and screening for CD19+ blast frequency in the peripheral blood was successfully established for monitoring of leukemia development before symptom onset. We conclude that facilities that breed RAG1-deficient mice should be aware of the risk of leukemia development in this strain and recommend to implement regular blood sampling for aged RAG1-deficient animals.
Exploring the multifactorial aspects of Gut Microbiome in Parkinson’s Disease
Authors: Pavan Sujith , Prabhu Arvind N. , Prasad Gorthi Sankar , Das Bhabatosh , Mutreja Ankur , Shetty Vignesh , Ramamurthy Thandavarayan , Ballal Mamatha
Published: May 2022

Advanced research in health science has broadened our view in approaching and understanding the pathophysiology of diseases and has also revolutionised diagnosis and treatment. Ever since the establishment of Braak’s hypothesis in the propagation of alpha-synuclein from the distant olfactory and enteric nervous system towards the brain in Parkinson’s Disease (PD), studies have explored and revealed the involvement of altered gut microbiota in PD. This review recapitulates the gut microbiome associated with PD severity, duration, motor and non-motor symptoms, and antiparkinsonian treatment from recent literature. Gut microbial signatures in PD are potential predictors of the disease and are speculated to be used in early diagnosis and treatment. In brief, the review also emphasises on implications of the prebiotic, probiotic, faecal microbiota transplantation, and dietary interventions as alternative treatments in modulating the disease symptoms in PD.
Impact of gastric and bowel surgery on gastrointestinal drug delivery
Authors: Hua Susan , Lye Ephraem C.
Published: May 2022

General surgical procedures on the gastrointestinal tract are commonly performed worldwide. Surgical resections of the stomach, small intestine, or large intestine can have a significant impact on the anatomy and physiological environment of the gastrointestinal tract. These physiological changes can affect the effectiveness of orally administered formulations and drug absorption and, therefore, should be considered in rational drug formulation design for specific pathological conditions that are commonly associated with surgical intervention. For optimal drug delivery, it is important to understand how different surgical procedures affect the short-term and long-term functionality of the gastrointestinal tract. The significance of the surgical intervention is dependent on factors such as the specific region of resection, the degree of the resection, the adaptive and absorptive capacity of the remaining tissue, and the nature of the underlying disease. This review will focus on the common pathological conditions affecting the gastric and bowel regions that may require surgical intervention and the physiological impact of the surgery on gastrointestinal drug delivery. The pharmaceutical considerations for conventional and novel oral drug delivery approaches that may be impacted by general surgical procedures of the gastrointestinal tract will also be addressed.

Graphical abstract
Can SGLT2 inhibitors answer unmet therapeutic needs in chronic kidney disease?
Authors: De Nicola Luca , Cozzolino Mario , Genovesi Simonetta , Gesualdo Loreto , Grandaliano Giuseppe , Pontremoli Roberto
Published: May 2022

Chronic kidney disease (CKD) is a global health problem, affecting more than 850 million people worldwide. The number of patients receiving renal replacement therapy (dialysis or renal transplantation) has increased over the years, and it has been estimated that the number of people receiving renal replacement therapy will more than double from 2.618 million in 2010 to 5.439 million in 2030, with wide differences among countries. The main focus of CKD treatment has now become preserving renal function rather than replacing it. This is possible, at least to some extent, through the optimal use of multifactorial therapy aimed at preventing end-stage kidney disease and cardiovascular events. Sodium/glucose cotransporter 2 inhibitors (SGLT2i) reduce glomerular hypertension and albuminuria with beneficial effects on progression of renal damage in both diabetic and non-diabetic CKD. SGLT2 inhibitors also show great benefits in cardiovascular protection, irrespective of diabetes. Therefore, the use of these drugs will likely be extended to the whole CKD population as a new standard of care.

Graphical abstract
Petrographic composition of coal within the Benue Trough, Nigeria and a consideration of the paleodepositional setting
Authors: Mangs A. D. , Wagner N. J. , Moroeng O. M. , Lar U. A.
Published: May 2022

The petrographic composition of Cretaceous-age coals hosted in the Benue Trough, Nigeria is presented and discussed in terms of the paleodepositional settings that influenced the coal-bearing formations. The Benue Trough is a failed arm of the triple junction of an inland sedimentary basin that extends in a NE-SW direction from the Gulf of Guinea in the south, to the Chad Basin in the north. A total of twenty-nine (29) coal samples were obtained from nineteen coal localities in the Upper (UBT), Middle (MBT), and Lower Benue Trough (LBT). The high average volatile matter yield, low average ash yield, high calorific value (24.82 MJ/kg, on average), and low sulphur values indicate good quality coal deposits. The organic matter is dominated by vitrinite, reported at an average of 59.3% by volume (mineral-matter free). Variation was noted in the inertinite content across three sub-regions. Liptinite macerals were not commonly observed in the studied samples and were absent in the MBT samples. Coal facies studies decipher the paleoenvironmental conditions under which the vegetation accumulated. Indices commonly used are the gelification index (GI), tissue preservation index (TPI), ground water index (GWI and variations), vegetation index (VI), and wood index (WI). Comparing the array of coal facies models applied, the MBT samples differ from the UBT and LBT samples, concurring with the coal quality data. The UBT and LBT coals formed in an upper deltaic to drier piedmont plane depositional environment, while the MBT coal formed in a lower deltaic marsh to wet forest swamp depositional environment. All samples indicate an ombrotrophic paleomire. In view of the modified equations and the plots used, interpreting depositional environments from just a single model is not reliable.
Analytical solution to logarithmic spiral trajectories with circumferential thrust and mission applications
Authors: Bassetto Marco , Quarta Alessandro A. , Mengali Giovanni
Published: May 2022

This study made use of a shape-based method to analyze the orbital dynamics of a spacecraft subject to a continuous propulsive acceleration acting along the circumferential direction. Under the assumption of a logarithmic spiral trajectory, an exact solution to the equations of motion exists, which allows the spacecraft state variables and flight time to be expressed as a function of the angular coordinate. There is also a case characterized by specific initial conditions in which the time evolution of the state variables may be analytically determined. In this context, the presented solution is used to analyze circle-to-circle trajectories, where the combination of two impulsive maneuvers and a logarithmic spiral path are used to accomplish the transfer. The determined results are then applied to the achievement of the Earth—Mars and the Earth—Venus transfers using actual data from a recent thruster developed by NASA.
Micro-Raman spectroscopic analysis on natural carbonates: linear relations found via biaxial plotting of peak frequencies for cation substituted species
Authors: Urashima Shu-hei , Nishioka Tomoya , Yui Hiroharu
Published: May 2022

Carbonates are ubiquitous minerals carrying important information on aqueous environments where they precipitated on the Earth and space. While their ideal chemical formulae are denoted as simple as MCO3 or M1M2(CO3)2 (M: metal cations), natural carbonates generally form solid-solution series and their compositions deviate from the ideal formulae. Since their cation composition due to the substitution provides a sensitive indicator for chemical and thermodynamic environments of aqueous solutions where they precipitated, their composition analysis has been widely carried out from the environmental/geochemical/astrochemical aspects. However, in widely used back-scattered electron and energy dispersion X-Ray analyses, samples should be generally sliced and/or their surface be polished prior to the measurements. For analyzing rare samples with small sizes, such as ones sampled from deep-sea and/or meteorites and asteroids, a non-destructive method without any pretreatments has been strongly desired. Here, a novel analytical method for discriminating various carbonates with Raman micro-spectroscopy is demonstrated, showing that the biaxial plot of the peak frequencies of their lattice modes linearly moves upon partial substitution of the cations. The cation substitution leads to linear movement in the biaxial map, and the slopes of the movement were different for Mg2+-Fe2+ and Mn2+-Fe2+ substitutions. This finding suggests that the micro-Raman analysis would be a non-destructive analytical method for evaluating the relative amount of Mg2+, Fe2+, and Mn2+ in dolomite-ankerite-kutnohorite solid-solution series, as well as Mg2+/Fe2+ ratio for magnesite-breunnerite-siderite. It would be helpful for analyzing the present and past terrestrial and cosmochemical environments.

Graphical abstract
Aerothermodynamics of a sphere in a monatomic gas based onab initiointeratomic potentials over a wide range of gas rarefaction: transonic, supersonic and hypersonic flows
Authors: Sharipov Felix , Volkov Alexey N.
Published: May 2022

Aerothermodynamic characteristics of a sphere such as drag and energy transfer coefficients are calculated for Mach numbers varying from 1 to 10 over a wide range of the gas rarefaction degree spanning the free molecular, transitional and near hydrodynamic flow regimes. The effects of major factors determining the gas flow are studied using the direct simulation Monte Carlo method. To reveal the effect of gas species, the simulations are performed based onab initiointeratomic potentials for helium, neon, argon and krypton, as well as based on the hard sphere model. The impact of the accommodation coefficients is evaluated by applying the Cercignani–Lampis model of gas–surface interaction. The calculations are carried out for several values of the free stream and sphere temperatures. It is found that the effects of gas species on the drag and energy transfer coefficients are approximately 3 % and 6 %, respectively. The accommodation coefficients in the Cercignani–Lampis model strongly affect all aerothermodynamic characteristics. The drag and energy transfer coefficients calculated for different accommodation coefficients vary within 30 % and 200 %, respectively. It is found that the variation of the tangential momentum and normal energy accommodation coefficients can induce an increase of the drag coefficient compared to the case of diffuse gas–surface interaction. In hypersonic flows, the drag coefficient varies within 30 % when the sphere temperature varies from the free stream temperature to the stagnation temperature. The drag and energy transfer coefficients are found to be non-monotonic functions of the free stream temperature.
Botánica Sephardica
Authors: Stein Sarah Abrevaya
Published: May 2022

This article traces the genealogy of a Jewish-owned botánica located in East Harlem in the 1930s and 1940s. Botánicas are understood to manifest an intricate, transatlantic religious, spiritual, and healing world, offering herbal products, sacramental goods, ritual implements, and counseling to Italian, Latinx, Black, and Caribbean practitioners of folk Catholicism, herbalism, hoodoo, Vodou, Santería, Espiritismo, Curanderismo, Òrìṣà worship and other ethnomedical and spiritual systems. Yet this botánica was owned by an Eastern Mediterranean Jew from the Ottoman/Italian island of Rhodes, and it integrated Sephardic and Mediterranean histories and sources of inspiration. Extraordinarily, this history stands for a greater whole. Jews were pioneering spiritual merchants in the United States. Restoring their history requires journeying globally, beginning with Ottomans’ fidelity to herbalism; tracing émigré Sephardic Jews’ uneven dialogue with Black African men and women in colonial Central and Southern Africa; and delving into the commercial, spiritual, and racial interplay furthered by Jewish-owned pharmacies and botánicas in New York City, Baltimore, Atlanta, Memphis, Charleston, Chicago, and Los Angeles and by Jewish spiritual merchants and their Caribbean, Latinx, and Black patrons. All this introduces an unexpected Jewish and Mediterranean history to the botánica, and an unexpectedly multifarious spiritual, mercantile, and racial dimension to Jewish history.