bluuebunny/crossref_metadata_2025 huggingface dataset:
Different Doses of Fingolimod in Relapsing-Remitting Multiple Sclerosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Wu Xin , Xue Tao , Wang Zilan , Chen Zhouqing , Zhang Xuwei , Zhang Wei , Wang Zhong
Published: May 2021

Background: The efficacy and safety of fingolimod for relapsing-remitting multiple sclerosis (RRMS) had been well verified in several large randomized controlled trials (RCTs) during the past decade. However, there are fewer systematic comparisons of different doses of fingolimod and whether the dose of 0.5 mg/d is the optimal one still remains to be solved.

Objective: The objective of this systematic review was to evaluate the efficacy and safety of the four existing doses of fingolimod in the treatment of RRMS, especially the dose of 0.5 mg/d.

Methods: MEDLINE, EMBASE, Cochrane Library, and clinicaltrials.gov were searched for RCTs which were performed to evaluate different doses of fingolimod and the corresponding control (placebo or DMTs) up to October 2020. Review Manager 5.3 software was used to assess the data. The risk ratio (RR) and mean difference (MD) was analyzed and calculated with a random effect model.

Results: We pooled 7184 patients from 11 RCTs. Fingolimod 0.5 mg/d was superior to control group in all eight efficacy outcomes including annualized relapse rate (ARR) (MD −0.22, 95%CI −0.29 to −0.14, p < 0.00001) but surprisingly showed a higher risk of basal-cell carcinoma (RR 4.40, 95%CI 1.58 to 12.24, p = 0.004). Although 1.25 mg/d is more than twice the dose of 0.5 mg/d, the effect size was almost similar between them. Dose of 5 mg/d obtained an unsatisfactory efficacy while showing a greater risk of adverse events than other three doses (RR 1.17, 95%CI 1.05 to 1.30, p = 0.003). Additionally, fingolimod 0.25 mg/d not only showed a better performance in delaying the disease progress of magnetic resonance imaging (MRI), but also achieved a certain degree of patient treatment satisfaction.

Conclusion: At present, 0.5 mg/d remains to be the optimal dose of fingolimod for RRMS patients but trials of a lower dose are still of great clinical significance and should be paid more attentions.
A Purified Biflavonoid Extract From Selaginella moellendorffii Alleviates Gout Arthritis via NLRP3/ASC/Caspase-1 Axis Suppression
Authors: Zhang Xueyan , Liu Yingbo , Deng Guangrui , Huang Bisheng , Kai Guoyin , chen Keli , Li Juan
Published: May 2021

Background: Activation of nucleotide oligomerization domain-like receptor protein 3 (NLRP3) inflammasome plays a crucial role in gout. Selaginella moellendorffii has been confirmed effective for the treatment of gout in hospital preparations. Flavonoids, such as amentoflavone (AM), are the main active components of this medicine.

Purpose: We aimed to investigate the flavonoid extract (TF) and AM's effects on NLRP3 inflammasome in vitro and their preventive effects on gout in vivo.

Methods: LC-MS method was employed to investigate the chemical profile of TF. The cellular inflammation model was established by lipopolysaccharide (LPS) or monosodium urate (MSU) stimulation. The cell membrane integrality and morphological characteristics were determined by using Lactate dehydrogenase (LDH) assay kits, propidium iodide (PI) stain, and scanning electron microscopy (SEM). The inflammatory cytokines and NLRP3 inflammasome activation were determined using enzyme-linked immunosorbent assay (ELISA), quantitative real-time polymerase chain reaction (RT-PCR), immunofluorescence staining, and western blotting. The acute gout mouse model was induced by MSU injection into footpads, and then the paw edema, inflammatory mediators, and histological examination (HE) were analyzed.

Results: The main constituents in TF are AM and robustaflavone. In the cellular inflammation model, TF down-regulated the levels of nitric oxide (NO), TNF-α, and LDH, suppressed NLRP3 inflammasome-derived interleukin-1β (IL-1β) secretion, decreased caspase-1 activation, repressed mature IL-1β expression, inhibited ASC speck formation and NLRP3 protein expression. In an acute gout mouse model, oral administration of TF to mice effectively alleviated paw edema, reduced inflammatory features, and decreased the levels of IL-1β in mouse foot tissue. Similarly, the characteristic constituent AM was also able to down-regulated the levels of NO, TNF-α, and LDH, down-regulate the mRNA expression of IL-1β, TNF-α, caspase-1, and NLRP3. Besides, the foot thickness, lymphocyte infiltration, and IL-1β level were also prevented by AM.

Conclusion: The results indicated that TF and its main constituent AM alleviate gout arthritis via NLRP3/ASC/Caspase-1 axis suppression.
Recurrence Plot-Based Approach for Cardiac Arrhythmia Classification Using Inception-ResNet-v2
Authors: Zhang Hua , Liu Chengyu , Zhang Zhimin , Xing Yujie , Liu Xinwen , Dong Ruiqing , He Yu , Xia Ling , Liu Feng
Published: May 2021

The present study addresses the cardiac arrhythmia (CA) classification problem using the deep learning (DL)-based method for electrocardiography (ECG) data analysis. Recently, various DL techniques have been utilized to classify arrhythmias, with one typical approach to developing a one-dimensional (1D) convolutional neural network (CNN) model to handle the ECG signals in the time domain. Although the CA classification in the time domain is very prevalent, current methods’ performances are still not robust or satisfactory. This study aims to develop a solution for CA classification in two dimensions by introducing the recurrence plot (RP) combined with an Inception-ResNet-v2 network. The proposed method for nine types of CA classification was tested on the 1st China Physiological Signal Challenge 2018 dataset. During implementation, the optimal leads (lead II and lead aVR) were selected, and then 1D ECG segments were transformed into 2D texture images by the RP approach. These RP-based images as input signals were passed into the Inception-ResNet-v2 for CA classification. In the CPSC, Georgia, and the PTB_XL ECG databases of the PhysioNet/Computing in Cardiology Challenge 2020, the RP-based method achieved an average F1-score of 0.8521, 0.8529, and 0.8862, respectively. The results suggested the excellent generalization ability of the proposed method. To further assess the performance of the proposed method, we compared the 2D RP-image-based solution with the published 1D ECG-based works on the same dataset. Also, it was compared with two traditional ECG transform into 2D image methods, including the time waveform of the ECG recordings and time-frequency images based on continuous wavelet transform (CWT). The proposed method achieved the highest average F1-score of 0.844, with only two leads of the 12-lead ECG original data, which outperformed other works. Therefore, the promising results indicate that the 2D RP-based method has a high clinical potential for CA classification using fewer lead ECG signals.
He-Ne Laser Seed Treatment Improves the Nutraceutical Metabolic Pool of Sunflowers and Provides Better Tolerance Against Water Deficit
Authors: Mahmood Saqib , Afzal Beenish , Perveen Shagufta , Wahid Abdul , Azeem Muhammad , Iqbal Naeem
Published: May 2021

Water-scarce areas are continually increasing worldwide. This factor reduces the quantity and quality of crops produced in affected areas. Physical seed treatments are considered economical and ecofriendly solutions for such problems. It was hypothesized that a moderately drought-tolerant crop grown from seeds treated with a He-Ne laser utilizes water-limited conditions better than plants grown from untreated seeds. A field study was conducted, growing a moderately drought tolerant crop (sunflower) with supportive seed treatment (He-Ne laser treatment at 300 mJ) for 0, 1, 2, and 3 min. Thirty-day-old plants were subjected to two irrigation conditions: 100% (normal) and 50% (water stress). Harvesting was done at flowering (60-day-old plants) at full maturity. The sunflowers maintained growth and yield under water limitation with a reduced achene number. At 50%, irrigation, there was a reduction in chlorophyll a, a+b and a/b; catalase activity; soluble sugars; and anthocyanin, alongside elevated proline. The improved chlorophyll a, a+b and a/b; metabolisable energy; nutritional value; and yield in the plants grown from He-Ne-laser-treated seeds support our hypothesis. Seeds with 2-min exposure to a He-Ne laser performed best regarding leaf area; leaf number; leaf biomass; chlorophyll a, a+b and a/b; per cent oil yield; 50-achene weight; achene weight per plant; carotenoid content; and total soluble phenolic compound content. Thereafter, the leaves from the best performing level of treatment (2 min) were subjected to high-performance-liquid-chromatography-based phenolic profiling and gas-chromatography-based fatty acid profiling of the oil yield. The He-Ne laser treatment led to the accumulation of nutraceutical phenolic compounds and improved the unsaturated-to-saturated fatty acid ratio of the oil. In conclusion, 2-min He-Ne laser seed treatment could be the best strategy to improve the yield and nutritional value of sunflowers grown in water-limited areas.
An Eggplant Recombinant Inbred Population Allows the Discovery of Metabolic QTLs Controlling Fruit Nutritional Quality
Authors: Sulli Maria , Barchi Lorenzo , Toppino Laura , Diretto Gianfranco , Sala Tea , Lanteri Sergio , Rotino Giuseppe Leonardo , Giuliano Giovanni
Published: May 2021

Eggplant (Solanum melongena L.) represents the third most important crop of the Solanaceae family and is an important component of our daily diet. A population of 164 F6 recombinant inbred lines (RILs), derived from two eggplant lines differing with respect to several key agronomic traits, “305E40” and “67/3,” was grown to the commercial maturation stage, and fruits were harvested, separated into peel and flesh, and subjected to liquid chromatography Liquid Chromatography/Mass Spectrometry (LC/MS) analysis. Through a combination of untargeted and targeted metabolomics approaches, a number of metabolites belonging to the glycoalkaloid, anthocyanin, and polyamine classes and showing a differential accumulation in the two parental lines and F1 hybrid were identified. Through metabolic profiling of the RILs, we identified several metabolomic quantitative trait loci (mQTLs) associated with the accumulation of those metabolites. Each of the metabolic traits proved to be controlled by one or more quantitative trait loci (QTLs); for most of the traits, one major mQTL (phenotypic variation explained [PVE] ≥ 10%) was identified. Data on mQTL mapping and dominance–recessivity relationships of measured compounds in the parental lines and F1 hybrid, as well as an analysis of the candidate genes underlying the QTLs and of their sequence differences in the two parental lines, suggested a series of candidate genes underlying the traits under study.
Commonly and Specifically Activated Defense Responses in Maize Disease Lesion Mimic Mutants Revealed by Integrated Transcriptomics and Metabolomics Analysis
Authors: Mu Xiaohuan , Li Jiankun , Dai Zhuangzhuang , Xu Liping , Fan Tianyuan , Jing Teng , Chen Mengyao , Gou Mingyue
Published: May 2021

Disease lesion mimic (Les/les) mutants display disease-like spontaneous lesions in the absence of pathogen infection, implying the constitutive activation of defense responses. However, the genetic and biochemical bases underlying the activated defense responses in those mutants remain largely unknown. Here, we performed integrated transcriptomics and metabolomics analysis on three typical maizeLesmutantsLes4,Les10, andLes17with large, medium, and small lesion size, respectively, thereby dissecting the activated defense responses at the transcriptional and metabolomic level. A total of 1,714, 4,887, and 1,625 differentially expressed genes (DEGs) were identified inLes4,Les10, andLes17, respectively. Among them, 570, 3,299, and 447 specific differentially expressed genes (SGs) were identified, implying a specific function of eachLESgene. In addition, 480 common differentially expressed genes (CGs) and 42 common differentially accumulated metabolites (CMs) were identified in allLesmutants, suggesting the robust activation of shared signaling pathways. Intriguingly, substantial analysis of the CGs indicated that genes involved in the programmed cell death, defense responses, and phenylpropanoid and terpenoid biosynthesis were most commonly activated. Genes involved in photosynthetic biosynthesis, however, were generally repressed. Consistently, the dominant CMs identified were phenylpropanoids and flavonoids. In particular, lignin, the phenylpropanoid-based polymer, was significantly increased in all three mutants. These data collectively imply that transcriptional activation of defense-related gene expression; increase of phenylpropanoid, lignin, flavonoid, and terpenoid biosynthesis; and inhibition of photosynthesis are generalnatures associated with the lesion formation and constitutively activated defense responses in those mutants. Further studies on the identified SGs and CGs will shed new light on the function of eachLESgene as well as the regulatory network of defense responses in maize.
New Item Selection Method Accommodating Practical Constraints in Cognitive Diagnostic Computerized Adaptive Testing: Maximum Deviation and Maximum Limitation Global Discrimination Indexes
Authors: Li Junjie , Ma Lihua , Zeng Pingfei , Kang Chunhua
Published: May 2021

Maximum deviation global discrimination index (MDGDI) is a new item selection method for cognitive diagnostic computerized adaptive testing that allows for attribute coverage balance. We developed the maximum limitation global discrimination index (MLGDI) from MDGDI, which allows for both attribute coverage balance and item exposure control. MLGDI can realize the attribute coverage balance and exposure control of the item. Our simulation study aimed to evaluate the performance of our new method against maximum global discrimination index (GDI), modified maximum GDI (MMGDI), standardized weighted deviation GDI (SWDGDI), and constraint progressive with SWDGDI (CP_SWDGDI). The results indicated that (1a) under the condition of realizing the attribute coverage balance, MDGDI had the highest attribute classification accuracy; (1b) when the selection strategy accommodated the practical constraints of the attribute coverage balance and item exposure control, MLGDI had the highest attribute classification accuracy; (2) adding the item exposure control mechanism to the item selection method reduces the classification accuracy of the attributes of the item selection method; and (3) compared with GDI, MMGDI, SWDGDI, CP_SWDGDI, and MDGDI, MLGDI can better achieve the attribute-coverage requirement, control item exposure rate, and attribute correct classification rate.
Musical Practice in Music Students During COVID-19 Lockdown
Authors: Nusseck Manfred , Spahn Claudia
Published: May 2021

The pandemic situation has forced students in higher education to use alternative learning routines due to reduced activities at universities and educational facilities. Especially music students needed to adapt their musical learning to this particular situation. Mostly affected by the lockdown was the musical practicing behavior, especially when practicing at the University of Music was not possible. In this study, music students in their second and third semesters were asked to provide information on their practicing situations during the coronavirus disease 2019 (COVID-19) lockdown. They were required to fill in questionnaires about the practicing time and concepts of self-efficacy and self-regulation for musical learning. The data of 18 music students were collected. For the analysis, they were compared with the answers of 15 music students who were asked the same questions half a year earlier before the pandemic situation occurred. The results showed that the music students relocated mostly to their parents' homes for practicing during the lockdown. In the amount of practicing, the bachelor of music students practiced less during lockdown compared with before the lockdown. The mean self-efficacy for musical learning did not differ between before and during the lockdown. For the self-regulated musical learning, the music students showed significantly higher values in the subscale on reflecting and creating a framework for the progress of musical learning during the lockdown. The findings indicate that the music students developed certain self-regulated learning skills during the lockdown and managed to find suitable solutions in continuing with their musical learning without reservation.
Mental Health, Well-Being, and Psychological Flexibility in the Stressful Times of the COVID-19 Pandemic
Authors: Wąsowicz Grażyna , Mizak Szymon , Krawiec Jakub , Białaszek Wojciech
Published: May 2021

This study investigated the relationships between selected emotional aspects of mental ill-health (depression, anxiety, and stress, DASS) and mental well-health (well-being) experienced during the COVID-19 pandemic. The theoretical model of the study was based on Martin Seligman’s positive psychology and PERMA theory and Paul Wong’s Existential Positive Psychology 2.0 Theory, which postulates that negative experiences contribute to well-being and personal growth. The static approach was complemented by exploring the mediating role of psychological flexibility (defined as acceptance and action in the current situation) in the relationship between negative emotions and well-being. The data were collected during the initial phase of the COVID-19 pandemic from 277 participants (221 women), aged M = 33.83, SD = 12.77. The results confirmed that negative emotions correlated negatively with various domains of well-being (PERM), except for accomplishment (completing tasks and fulfill daily responsibilities). Moreover, negative emotions were related to the general well-being through psychological flexibility in that higher depression, anxiety, and stress were associated with lower psychological flexibility, which decreased general well-being. Finally, negative emotions were shown to be beneficial, having an adaptive effect that allows individuals to maintain their ability to cope with the situation, reach goals, and fulfill daily duties and responsibilities despite critical, stressful situation (like the COVID-19 pandemic) that limit their psychological flexibility. This observation confirmed the positive potential of negative aspects of life postulated within Existential Positive Psychology.
Malaysian Stakeholder Perspectives on Suicide-Related Reporting: Findings From Focus Group Discussions
Authors: Ng Yin Ping , Pheh Kai Shuen , Panirselvam Ravivarma Rao , Chan Wen Li , Lim Joanne Bee Yin , Lim Jane Tze Yn , Leong Kok Keong , Bartlett Sara , Tay Kok Wai , Chan Lai Fong
Published: May 2021

Media guidelines on safe suicide-related reporting are within the suicide prevention armamentarium. However, implementation issues beleaguer real-world practice. This study evaluated the perspectives of the Malaysian media community, persons with lived experience of suicidal behavior (PLE), and mental health professionals (MHP) on suicide-related reporting in terms of the impact, strategies, challenges, and the implementation of guidelines on safe reporting. Three focus group discussions of purposively sampled Malaysian media practitioners (n = 8), PLE (n = 6), and MHP (n = 7) were audio-recorded, transcribed, coded and thematically analyzed. Inclusion criteria were: English fluency, no clinical depression or suicidal ideation (current), no recent previous suicide attempts or suicide bereavement. Three major themes emerged: (1) Unsafe Reporting; (2) Impact; and (3) Safe Reporting. Most described current reporting as unsafe by being potentially triggering to media users and may contribute to contagion effect. Positive impacts identified included raised awareness toward suicide and its prevention. Unsafe reporting was attributed to inadequate awareness, knowledge, and guidance, lack of empathy and accountability, job-related factors, popularity-seeking, lack of monitoring and governance, and information source(s) with unsafe content. Majority agreed on how suicide stories should be framed to produce a safe report. The media community diverged on how detailed a suicide story should be. Safe reporting challenges included difficulties in balancing beneficial versus harmful details, social media ubiquity and its citizen reporters. Participants suggested these safe reporting strategies: stakeholder engagement, educational approaches, improving governance and surveillance, and guidelines revision. Most acknowledged the relevance of guidelines but were unaware of the existence of local guidelines. Implementation challenges included the dilemma in balancing media industry needs vis-à-vis safe reporting requirements, stakeholder engagement difficulties and social media regulation. There is poor awareness regarding safe suicide-related reporting across all groups. PLE and MHP were negatively impacted by current unsafe messaging which aggravated trauma and grief reactions. Postvention support gaps for mental health professionals were highlighted. Safe reporting promotion strategies should include stakeholder engagement to increase awareness on minimizing Werther and maximizing Papageno effects. Strategic re-examination and dissemination of local media guidelines to address new media issues, and effective surveillance mechanisms, are crucial in sustainable improvement of safe reporting practices.
Bilingualism Enhances Reported Perspective Taking in Men, but Not in Women
Authors: Tarighat Samaneh , Krott Andrea
Published: May 2021

Bilingual speakers have often been found to be superior in taking the perspective of another person. Also, females are commonly found to have enhanced perspective taking (PT) abilities compared with males, with male PT being generally more easily affected by external factors. The present study investigated whether bilingualism improves PT in males more strongly than in females. In total, 108 bilingual and 108 matched monolingual adults, with equal numbers of males and females, filled in the PT subscale of the Interpersonal Reactivity index. While monolinguals showed the typical result of females scoring higher on PT than males, scores of male and female bilinguals did not differ, with both bilingual groups scoring as high as female monolinguals. Thus, bilingualism enhanced self-reported PT only in males, suggesting that male PT can be enhanced through socialization.
Structured Professional Judgment to Assist the Evaluation and Safety Planning of Suicide Risk: The Risk of Suicide Protocol (RoSP)
Authors: Gray Nicola S. , John Ann , McKinnon Aimee , Raybould Stephanie , Knowles James , Snowden Robert J.
Published: May 2021

Background: The Risk of Suicide Protocol (RoSP) is a structured professional judgment (SPJ) scheme designed in line with NICE guidelines to improve clinicians' ability to evaluate and manage suicide risk.

Aims: This study aimed to evaluate the efficacy of RoSP in two settings: (1) unexpected deaths of people in the community who were known to mental health services; and (2) an inpatient hospital specializing in the assessment and treatment of patients with personality disorder.

Method: In Study 1, information from a database of unexpected deaths (N = 68) within an NHS health board was used to complete a RoSP assessment (blind to cause of death) and information from the Coroner's Court was used to assign people to suicide vs. natural causes/accidental death. In Study 2, patients (N = 62) were assessed on the RoSP upon admission to hospital and their self-injurious behaviors were recorded over the first 3 months of admission.

Results: (1) Evaluations using RoSP were highly reliable in both samples (ICCs 0.93–0.98); (2) professional judgment based on the RoSP was predictive of completed suicide in the community sample (AUC = 0.83) and; (3) was predictive of both suicide attempts (AUC = 0.81) and all self-injurious behaviors (AUC = 0.80) for the inpatient sample.

Conclusion: RoSP is a reliable and valid instrument for the structured clinical evaluation of suicide risk for use in inpatient psychiatric services and in community mental health services. RoSP's efficacy is comparable to well-established structured professional judgment instruments designed to predict other risk behavior (e.g., HCR-20 and the prediction of violence). The use of RoSP for the clinical evaluation of suicide risk and safety-planning provides a structure for meeting NICE guidelines for suicide prevention and is now evidence-based.
The Role of Military Training in Improving Psychological Resilience and Reducing Depression Among College Freshmen
Authors: Guo Rui , Sun Meng , Zhang Chi , Fan Zebin , Liu Zhening , Tao Haojuan
Published: May 2021

Background: Military training plays an important protective role in enhancing mental health. However, the effects of military training on psychological resilience and depression among college freshmen in China remain unclear. The present study aimed to evaluate changes in psychological resilience and depression through military training among college freshmen, and to investigate associated psychosocial factors including childhood trauma that may influence its effects on psychological resilience.

Methods: A prospective and self-comparison study design was employed. College freshmen who received 3 weeks of military training were recruited. Socio-demographic variables were collected and childhood trauma exposure was estimated by the Childhood Trauma Questionnaire (CTQ). The Connor-Davidson Resilience Scale (CD-RISC) and Patient Health Questionnaire (PHQ-9) were used to assess psychological resilience and depression before and after the military-style training.

Results: The military training significantly increased the total and subscale scores of CD-RISC (p < 0.001), and decreased the PHQ-9 score (p < 0.001). The proportion of students with clinical depression reduced from 10.5% at baseline to 7.2% after the training (p < 0.001). Improvement of CD-RISC scores was positively affected by male gender and urban area, while negatively affected by older age, and higher baseline scores of PHQ-9 and CTQ. A significant correlation was found between changes in scores of CD-RISC and PHQ-9 through the training (r = −0.238, p < 0.001).

Conclusions: Military training may have a positive effect on increasing psychological resilience and reducing depressive symptoms among college freshmen, especially in male students and those from an urban area, while older age, childhood trauma, higher depression levels, and resilience at baseline may weaken, or even mask its positive effect. Follow-up research should be considered for the long-term effects of military-style training.
Effects of Hormonal Contraception Use on Cognitive Functions in Patients With Bulimia Nervosa
Authors: Nobile Benedicte , Maimoun Laurent , Jaussent Isabelle Danielle , Seneque Maude , Dupuis-Maurin Kathlyne , Lefebvre Patrick , Courtet Phillippe , Renard Eric , Guillaume Sebastien
Published: May 2021

Background: Growing evidences indicate that sex hormones have an effect on cognitive functions, and that Bulimia Nervosa (BN) is associated with cognitive impairment. The aim of this study was to determine the effect of hormonal contraception (HC) use on four cognitive functions that are impaired in patients with BN.

Methods: This retrospective exploratory study included 103 women with a diagnosis of BN based on the DSM-5 criteria. Their age ranged from 15 to 45 years, and 46.6% were taking HC (oral, transdermal, or intrauterine). Cognition was assessed with the d2 test (attention), Iowa gambling task (IGT; decision making), Brixton spatial anticipation test (set shifting), and Rey-Osterrieth complex figure test (central coherence). Data were analyzed with logistic regression models to estimate the adjusted odds ratios (OR) and 95% confidence intervals (CI) of HC effect on the neuropsychological test scores.

Results: In the multivariate model, HC use was significantly associated with better scores for two d2 test indices: F-score [OR = 0.98, 95% CI = (0.95; 0.99)] and final total score ratio [OR = 0.87, 95% CI = (0.77; 0.99)]. HC was also associated with a better understanding of the IGT explicit rules. No difference between the two groups (HC and non-HC use) was detected for set shifting and central coherence.

Conclusions: This exploratory study suggests that HC could have effects on the sustained attention and concentration in women with BN. More studies are needed to confirm these results.
COVID-19 in People With Schizophrenia: Potential Mechanisms Linking Schizophrenia to Poor Prognosis
Authors: Mohan Mohapradeep , Perry Benjamin Ian , Saravanan Ponnusamy , Singh Swaran Preet
Published: May 2021

As the global burden of mortality from COVID-19 continues to rise, an understanding of who is most at risk of adverse outcomes is of paramount importance. Pre-existing cardiometabolic, renal and respiratory diseases as well as old age are well-established risk factors associated with disease severity and mortality among patients with COVID-19. However, mounting evidence also indicates an increased susceptibility to, and risk of adverse outcomes from COVID-19 in people with schizophrenia, independent of age and comorbidity. Therefore, elucidating the underlying pathophysiological mechanisms which may increase the risk of poor outcomes in people with schizophrenia is of crucial importance. Here, we provide a narrative on the current understanding of COVID-19 in patients with schizophrenia and propose potential mechanisms which may link schizophrenia with an increased susceptibility to, and greater risk of adverse outcomes from COVID-19. Given the existing knowledge gaps, robust clinical and biological studies are required to further our understanding of some of these underlying mechanisms, so that effective prevention and treatment strategies for COVID-19 in patients with schizophrenia can be developed.
Using Telemedicine During the COVID-19 Pandemic: Attitudes of Adult Health Care Consumers in Israel
Authors: Reicher Sima , Sela Tal , Toren Orly
Published: May 2021

Introduction:The COVID-19 pandemic has affected health care services worldwide due to lockdowns, prevention measures, and social distancing. During this period, patients, including older adults and those with chronic conditions, need ways to obtain medical attention other than going physically to the clinic, such as telemedicine services. The purpose of the present study was to evaluate attitudes toward telemedicine during the COVID-19 lockdown in Israel, assess willingness to use such services in the future, and evaluate the extent to which consumers have changed their minds regarding these services.

Method:A cross-sectional, descriptive, correlational study was conducted among adults (age 20–90) using social media networks (N= 693). Data were collected using an online questionnaire explicitly designed to measure attitudes toward telemedicine.

Results:Most of the participants had to use telemedicine during the lockdown and were satisfied therewith. The majority also stated that they would continue using telemedicine in the future. However, only a third stated that they had changed their minds regarding telemedicine. The main predictors of willingness to use telemedicine in the future were the necessity of using such services during lockdown, preference for going to a clinic, and satisfaction with telemedicine, alongside gender and having a chronic illness. Importantly, we found that a preference for visiting the clinic was negatively correlated with willingness to use telemedicine in the future. Education and being single were predictors of the change of mind regarding telemedicine. Participants with chronic conditions are more likely to use these services, and specific attention should be directed to their needs. A small portion of the study sample prefers live appointments with a physician.

Conclusions:Telemedicine use is rapidly changing. It is vital for health care providers to identify non-telemedicine users and their common characteristics. Monitoring patients' attitudes regarding telemedicine is essential in the future after the pandemic ends. Targeted outreach plans should be formulated. These plans should be directed at identifying barriers to using telemedicine, and they should generate specific, focused plans.
Prevalence and Related Factors of Depression, Anxiety, Acute Stress, and Insomnia Symptoms Among Medical Staffs Experiencing the Second Wave of COVID-19 Pandemic in Xinjiang, China
Authors: Zhao Yongzhi , Guo Junlong , Liu Shuai , Aizezi Muyeseer , Zeng Qiong , Sidike Ashenggu , Abliz Raziya , Kudireti Aisikaerjiang , Xie Yan , Taineikuli Atikan , Zhang Bin
Published: May 2021

The prevalence and related factors of mental health impact among medical staffs who experienced the second wave of the COVID-19 pandemic in China is unknown. Therefore, this survey was conducted to investigate the prevalence and related factors of depressive, anxiety, acute stress, and insomnia symptoms in medical staffs in Kashi, Xinjiang, China during the second wave of the COVID-19 pandemic. A cross-sectional online survey was conducted among medical staffs working in First People's Hospital of Kashi, Xinjiang. The questionnaire collected demographic data and self-design questions related to the COVID-19 pandemic. The Impact of Events Scale-6, the Insomnia Severity Index, the Patient Health Questionnaire-9, the Generalized Anxiety Disorder Scale-7, the Perceived Social Support Scale, the Chinese Big Five Personality Inventory-15, and the Trait Coping Style Questionnaire were used to measure psychological symptoms or characteristics. Binary logistic regression was carried out to examine the associations between socio-demographic factors and symptoms of depression, anxiety, stress, and insomnia. In total, data from 123 participants were finally included, among which the prevalence rate of depressive, anxiety, acute stress, and insomnia symptoms is 60.2, 49.6, 43.1, and 41.1%, respectively. The regression model revealed that minority ethnicity, being worried about infection, spending more time on following pandemic information, and neurotic personality were positively associated with the mental health symptoms, while extraversion personality, higher education level, and better social support were negatively associated. In our study, the prevalence of mental health impact was high among medical staffs in Kashi, China who experienced the second wave of the COVID-19 pandemic. Several factors were found to be associated with mental health conditions. These findings could help identify medical staffs at risk for mental health problems and be helpful for making precise mental health intervention policies during the resurgence. Our study may pave way for more research into Xinjiang during the COVID-19 pandemic.
Virtual Cohorts and Synthetic Data in Dementia: An Illustration of Their Potential to Advance Research
Authors: Muniz-Terrera Graciela , Mendelevitch Ofer , Barnes Rodrigo , Lesh Michael D.
Published: May 2021

When attempting to answer questions of interest, scientists often encounter hurdles that may stem from limited access to existing adequate datasets as a consequence of poor data sharing practices, constraining administrative practices. Further, when attempting to integrate data, differences in existing datasets also impose challenges that limit opportunities for data integration. As a result, the pace of scientific advancements is suboptimal. Synthetic data and virtual cohorts generated using innovative computational techniques represent an opportunity to overcome some of these limitations and consequently, to advance scientific developments. In this paper, we demonstrate the use of virtual cohorts techniques to generate a synthetic dataset that mirrors a deeply phenotyped sample of preclinical dementia research participants.
Resilience Meets Sustainable and Spiritual Background Into an Initial Review for the New Normal After the COVID-19 Pandemic
Authors: Bella Ricardo Luiz Fernandes , Barboza Douglas Vieira , Quelhas Osvaldo Luiz Gonçalves , Meiriño Marcelo Jasmim , França Sergio Luiz Braga
Published: May 2021

Objective: This work aims to generate an initial basis for a discussion of the strategic structuring of values that impact the perspective of planning at its different levels within the scope of organizational human relations. The value highlighted in this article is an intersection between organizational resilience and spirituality at work, through which production systems can maintain internal quality even after conforming to external pressures from the environment and moving toward sustainability.

Design/Methodology/Approach: The methodology applied in this research consists of consulting and organizing a previous knowledge base of a research and development group in technology and sustainability. This knowledge base is based on research, articles, and books on sustainability and corporate responsibility. Then, this more sedimented knowledge base finds the most recent construction of the concept of spirituality in the workplace for the topic of interest from a triangulation of the concept of resilience, corporate sustainability, and spirituality at work.

Results: The main findings of this research, if in the reflections on the impact of attribute resilience in the development and maintenance of productive systems. The main issue observed is the correspondence of the identity of the human being with identity, enabling the production of a predictable planning environment in the aspects of motivation and engagement to overcome moments of crisis.

Originality/Value: The originality of the article involves the construction of an abstract approach system to understand an attribute that, according to the literature, can be developed and articulated to achieve a perennial organizational performance in society.
Genomic and Transcriptomic Characterization of Canine Osteosarcoma Cell Lines: A Valuable Resource in Translational Medicine
Authors: Gola Cecilia , Giannuzzi Diana , Rinaldi Andrea , Iussich Selina , Modesto Paola , Morello Emanuela , Buracco Paolo , Aresu Luca , De Maria Raffaella
Published: May 2021

Osteosarcoma (OSA) represents the most common primary bone tumor in dogs and is characterized by a highly aggressive behavior. Cell lines represent one of the most suitable and reproducible pre-clinical models, and therefore the knowledge of their molecular landscape is mandatory to investigate oncogenic mechanisms and drug response. The present study aims at determining variants, putative driver genes, and gene expression aberrations by integrating whole-exome and RNA sequencing. For this purpose, eight canine OSA cell lines and one matched pair of primary tumor and normal tissue were analyzed. Overall, cell lines revealed a mean tumor mutational burden of 9.6 mutations/Mb (range 3.9–16.8). Several known oncogenes and tumor suppressor genes, such as ALK, MYC, and MET, were prioritized as having a likely role in canine OSA. Mutations in eight genes, previously described as human OSA drivers and including TP53, PTCH1, MED12, and PI3KCA, were retrieved in our cell lines. When variants were cross-referenced with human OSA driver mutations, the E273K mutation of TP53 was identified in the Wall cell line and tumor sample. The transcriptome profiling detected two possible p53 inactivation mechanisms in the Wall cell line on the one hand, and in D17 and D22 on the other. Moreover, MET overexpression, potentially leading to MAPK/ERK pathway activation, was observed in D17 and D22 cell lines. In conclusion, our data provide the molecular characterization of a large number of canine OSA cell lines, allowing future investigations on potential therapeutic targets and associated biomarkers. Notably, the Wall cell line represents a valuable model to empower prospective in vitro studies both in human and in dogs, since the TP53 driver mutation was maintained during cell line establishment and was widely reported as a mutation hotspot in several human cancers.
A Numerical and Experimental Study on an Interconnected Metamaterial for Flexural Vibration Control Based on Modal Strain Energy
Authors: Kim Hyun-Guk , Jeon Onyu , Wang Semyung
Published: May 2021

In this study, an interconnected metamaterial was proposed to suppress flexural vibration. The interconnected metamaterial can improve the manufacturing and installation processes in terms of convenience because it can be fabricated in the form of a modular multi-celled structure with a single-phase material. To evaluate the vibration reduction performance of the metamaterial, stopband analysis was performed, as it solves an iterative eigenvalue problem for the wave vector domain. In order to identify the Bloch mode that contributes to flexural vibration, a concept to extract the Bloch mode based on the modal strain energy was proposed. The vibration-reduction performance of the interconnected metamaterial was numerically verified by using a frequency-response analysis of the multi-celled structure. The interconnected metamaterial proposed in this study was fabricated by using a 3D printer. Finally, the vibration-reduction performance of the multi-celled structure was experimentally verified by using impact testing.
Effects of Vertical Glottal Duct Length on Intraglottal Pressures in the Convergent Glottis
Authors: Li Sheng , Scherer Ronald C. , Wan Mingxi
Published: May 2021

In a previous study, the vertical glottal duct length was examined for its influence on intraglottal pressures and other aerodynamic parameters in the uniform glottis [J Voice 32, 8–22 (2018)]. This study extends that work for convergent glottal angles, the shape of the glottis during the glottal opening phase of vocal fold vibration. The computational fluid dynamics code ANSYS Fluent 6.3 was used to obtain the pressure distributions and other aerodynamic parameters for laminar, incompressible, two-dimensional flow in a static vocal fold model. Four typical vertical glottal duct lengths (0.108, 0.308, 0.608, 0.908 cm) were selected for three minimal diameters (0.01, 0.04, 0.16 cm), three transglottal pressures (500, 1000, 1500 Pa), and three convergent glottal angles (−5°, −10°, −20°). The results suggest that a longer vertical glottal duct length increases the intraglottal pressures, decreases the glottal entrance loss coefficient, increases the transglottal pressure coefficient, causes a lower gradient of both the intraglottal flow velocity and the wall shear stress along the glottal wall—especially for low flows and small glottal minimal diameters—and has little effect on the exit pressure coefficient and volume flow. The vertical glottal duct length in the convergent glottis has important effects on phonation and should be well specified when building computational and physical models of the vocal folds.
Floor Heave Mechanism and Anti-Slide Piles Control Technology in Deep and Large-Span Chamber
Authors: Shi Jian , Kong Desen
Published: May 2021

Based on plastic limit analysis, the deformation and fracture mechanism of the floor in the large-span chambers of deep mines are discussed and a similarity model test is carried out to verify the reliability of the theoretical analysis. The results show that the local shear failure first appears below the loading area and develops to the middle part of the test model with the increase in load; when the local shear failure develops to form a continuous sliding surface, continuous plastic flow deformation occurs; the distribution of the plastic zone and the deformation mode obtained from the similarity model test are basically consistent with the Hill-like deformation mode derived from plastic limit analysis. A control technology with anti-slide piles is proposed in order to deal with floor heave in large-span chambers on the basis of previous work. An approach for determining the supporting parameters of anti-slide piles is deduced. To deal with the floor heave in the −1100 level gangue winch room of the Huafeng Coal Mine, a comprehensive reinforcement scheme with anti-slide piles composed of discarded rails and anti-floating anchors is introduced for the floor heave control of the chambers. Site monitoring results show that the scheme not only effectively restrains the development of floor heave, but also ensures the long-term stability of the chamber floor.
Neuroergonomics: A Perspective from Neuropsychology, with a Proposal about Workload
Authors: Hardy David J.
Published: May 2021

In a brief overview of neuroergonomics, including some personal reminiscences of Raja Parasuraman, it is recognized that the field of human factors and ergonomics has benefitted greatly from the inclusion and integration of neuroscientific methods and theory. It is argued that such synergistic success can work in the other direction as well with the inclusion of methods and theory of human factors by a neuro field, in this case, neuropsychology. More specifically, it is proposed that neuropsychology can benefit from the inclusion of workload measures and theory. Preliminary studies on older adults, persons living with HIV, and patients with a traumatic brain injury or multiple sclerosis, are reviewed. As an adjunct measure to neuropsychological tests, the construct of workload seems perfectly suited to provide an additional vector of information on patient status, capturing some of the large individual differences evident in clinical populations and facilitating the early detection of cognitive change.
Artificial Intelligence Applications to Improve the Treatment of Locally Advanced Non-Small Cell Lung Cancers
Authors: Hope Andrew , Verduin Maikel , Dilling Thomas J , Choudhury Ananya , Fijten Rianne , Wee Leonard , Aerts Hugo JWL , El Naqa Issam , Mitchell Ross , Vooijs Marc , Dekker Andre , de Ruysscher Dirk , Traverso Alberto
Published: May 2021

Locally advanced non-small cell lung cancer patients represent around one third of newly diagnosed lung cancer patients. There remains a large unmet need to find treatment strategies that can improve the survival of these patients while minimizing therapeutical side effects. Increasing the availability of patients’ data (imaging, electronic health records, patients’ reported outcomes, and genomics) will enable the application of AI algorithms to improve therapy selections. In this review, we discuss how artificial intelligence (AI) can be integral to improving clinical decision support systems. To realize this, a roadmap for AI must be defined. We define six milestones involving a broad spectrum of stakeholders, from physicians to patients, that we feel are necessary for an optimal transition of AI into the clinic.
Breaching the Blood–Brain Tumor Barrier for Tumor Therapy
Authors: Marcucci Fabrizio , Corti Angelo , Ferreri Andrés J. M.
Published: May 2021

Tumors affecting the central nervous system (CNS), either primary or secondary, are highly prevalent and represent an unmet medical need. Prognosis of these tumors remains poor, mostly due to the low intrinsic chemo/radio-sensitivity of tumor cells, a meagerly known role of the microenvironment and the poor CNS bioavailability of most used anti-cancer agents. The BBTB is the main obstacle for anticancer drugs to achieve therapeutic concentrations in the tumor tissues. During the last decades, many efforts have been devoted to the identification of modalities allowing to increase drug delivery into brain tumors. Until recently, success has been modest, as few of these approaches reached clinical testing and even less gained regulatory approval. In recent years, the scenario has changed, as various conjugates and drug delivery technologies have advanced into clinical testing, with encouraging results and without being burdened by a heavy adverse event profile. In this article, we review the different approaches aimed at increasing drug delivery to brain tumors, with particular attention to new, promising approaches that increase the permeability of the BBTB or exploit physiological transport mechanisms.