bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmaceutical development of Lekhaniya Mahakashaya into dispersible tablet–A polyherbal formulation
Authors: Sakshi  , Hiremath Rajendraswami S. , Mannur Vinod Shrishaila
Published: August 2023

BACKGROUND:

Lekhaniya Mahakashaya (LM) is indicated in Ayurveda for obesity. Its classical dosage form is Kashaya (decoction), which involves time-consuming preparation and has a low shelf-life. The aim of the study was, therefore, to modify the dosage form of LM into a dispersible tablet (DT), a unit solid dosage form close to decoction, due to its conversion into aqueous solution during administration.

METHODS:

Raw materials were authenticated as per API standards. To develop and optimize the DT, totally six trials for each of the 30 tablets were carried out by direct compression method using two super disintegrants, viz., Sodium Starch Glycolate (SSG) and Croscarmellose Sodium, with the effervescent agents, tartaric acid, and sodium bicarbohydrate. The developed formulation was analyzed for its pre- and post-compression parameters besides Fourier transform infrared (FTIR).

RESULTS:

The formulation made using Anhydrous Lactose (AL) as a binding agent and SSG as a super disintegrant passed all the quality parameters of a DT. The average weight was 500 mg. The angle of repose was 0.600, Carr’s index was 19.40, and Hausner’s ratio was 1.24. Disintegration time was 2.5 min, friability was less than 1%, hardness was 2.5, and weight variation was less than 5%. FTIR revealed the presence of functional groups such as phenolics, alcohol, alkene, and nitride.

CONCLUSION:

LM can be modified into a DT using AL as a binding agent and SSG as a super disintegrant. Further studies are warranted to fix the clinical dose and assess efficacy.
Pharmaceutical standardization and analytical validation of Sanjivani Vati
Authors: Kaushik Shreshtha , Yadav Pramod , Prajapati Pradeep Kumar
Published: August 2023

BACKGROUND:

Standardization and validation for Ayurvedic polyherbal preparation using modern techniques of analysis are extremely important. Sanjivani Vati (SV) is one such a multicomponent formulation, which is well known for its multiple uses. Even so, it lacks the latest scientific measures to ensure its safety and efficacy more precisely. So, an attempt has been made to standardize the pharmaceutical procedure of SV and to validate its analytical profile. To develop Standard Manufacturing Procedure (SMP) of SV and to validate its quality control parameters.

METHODS:

Five batches of SV were prepared in the pharmaceutical laboratory, All India Institute of Ayurveda, New Delhi, India, following a classical reference. They were further subjected to an organoleptic, relevant physicochemical and physical, heavy metal, and microbial limit analysis along with a chromatographic as well as spectroscopic evaluation, that is, Fourier transform infrared spectroscopy (FTIR) and gas chromatography-mass spectrum (GCMS).

RESULTS:

A batch size of 100 g of SV can be prepared by using 10 g of its each ingredient, 250 mL of cow’s urine required for levigation of 6 h 45 min with a yield of around 730 pills of average weight 130.64 ± 2.43 mg, and after drying for 5 h 52 min at 50°C. These findings accomplished the chief objective of its pharmaceutical standardization. Analytical specifications of SV are highly amorphous powder, mild bitter in taste with odor of cow’s urine and having brownish black color. All the physicochemical parameters were found validated as per official standards except total ash value. Moreover, FTIR showed the presence of hydroxy, alkane, amide, acyl, alkoxy, and aromatic compounds. Fingerprinting assay revealed seven and nine retardation factor values at 254 and 366 nm, respectively. Furthermore, a total of 21 compounds were detected in GCMS. Pills were also observed free from specific heavy metals, microbes, and pesticides indicating good manufacturing practices.

CONCLUSION:

This is a preliminary report generating results for standardization as well as validation of SV that could be used for future references. Moreover, further works should be carried out to explore the therapeutic outcomes of this medication.
Effects of propofol-based total intravenous anesthesia versus desflurane anesthesia on natural killer cell cytotoxicity after hepatocellular carcinoma resection
Authors: Apisutimaitri Kirada , Saeyup Pipat , Suppipat Koramit , Sirichindakul Pongserath , Wanasrisant Nattanit , Nonsri Chawisachon , Lertprapai Panas
Published: August 2023

Background and Aims:

Inhalation anesthesia suppresses the immune system and stimulates the growth of tumor cells, contrary to intravenous anesthesia. However, no consensus exists on which anesthetic technique is better for preventing cancer recurrence. Therefore, this study compared the effects of two different anesthetic techniques on natural killer cell cytotoxicity (NKCC) in hepatocellular carcinoma (HCC) patients undergoing open hepatic resection.

Material and Methods:

Patients diagnosed with nonmetastatic HCC were scheduled for hepatic resection and randomly assigned to receive either propofol- or desflurane-based anesthesia. The primary outcome was pre- and postoperative NKCC assay. Cytokine levels were assessed by measuring interleukin (IL)-2, IL-4, IL-6, IL-10, tumor necrosis factor-alpha (TNF-α), and interferon-gamma (IFN-γ) levels, and the secondary outcome was postoperative cancer recurrence evaluated using diagnostic imaging scans for 2 years.

Results:

Twenty-eight patients were analyzed, including 15 and 13 in the total intravenous anesthesia (TIVA) and inhalation (INH) groups, respectively. Two patients in the INH group were excluded due to non-HCC postoperative pathologic results. At 24 h, the postoperative change in NKCC between both groups showed no significant differences at a ratio of effector cell: target cell = 1:1, 5:1, and 10:1 (P = 0.345, 0.345, and 0.565, respectively). Also, there were no significant differences in IL-2, IL-4, IL-6, IL-10, TNF-α, and IFN-γ levels (P = 0.588, 0.182, 0.730, 0.076, 0.518, 0.533, respectively). Postoperative tumor recurrence occurred in five and six patients in the TIVA and INH groups, respectively.

Conclusion:

NKCC did not differ significantly among HCC patients undergoing open hepatic resection under either propofol or desflurane anesthesia 24 h postoperatively.
Use of ultrasound to estimate the prevalence of occult spinal dysraphism in children undergoing urogenital and anorectal surgeries: A cross-sectional study
Authors: Toms Ann Sumin , Rai Ekta , John Novin Chacko , Panwar Jyoti
Published: August 2023

Background and Aim:

The use of ultrasound has immensely increased the safety toward regional blocks and central venous access and has been considered as the standard of care for securing central access. The aim of this study is to estimate the prevalence of occult spinal dysraphism using ultrasound in children less than 2 years of age undergoing elective urogenital or anorectal surgery.

Material and Methods:

The lumbosacral region of 159 American Society of Anesthesiologists (ASA) category I/II patients, posted for elective urogenital and anorectal surgery was scanned with ultrasound, prior to giving caudal block.

Results:

The prevalence of occult spina bifida was 3% in our study. There was no statistically significant association of cutaneous marker with abnormal scan.

Conclusion:

Prevalence of occult spina bifida was ten-times higher in our study than in the general population. Perioperative ultrasound screening of the lower spinal anatomy by anesthesiologist done prior to performing neuraxial block is worthwhile in ruling out occult spinal anomalies in high-risk children of occult spinal dysraphism.
Instantaneous convexity breaking for the quasi-static droplet model
Authors: Chau Albert , Weinkove Ben
Published: August 2023

We consider a well-known quasi-static model for the shape of a liquid droplet. The solution can be described in terms of time-evolving domains in

\mathbb{R}^n

. We give an example to show that convexity of the domain can be instantaneously broken.
Schrödinger equations defined by a class of self-similar measures
Authors: Ngai Sze-Man , Tang Wei
Published: August 2023

We study linear and non-linear Schrödinger equations defined by fractal measures. Under the assumption that the Laplacian has compact resolvent, we prove that there exists a unique weak solution for a linear Schrödinger equation, and then use it to obtain the existence and uniqueness of a weak solution of a non-linear Schrödinger equation. We prove that for a class of self-similar measures on

\mathbb{R}

with overlaps, the linear Schrödinger equations can be discretized so that the finite element method can be applied to obtain approximate solutions. We also prove that the numerical solutions converge to the actual solution and obtain the rate of convergence.
Factores que aplazan la atención de los procedimientos administrativos en las municipalidades de La Libertad
Authors: Agüero Lovatón José Luis
Published: August 2023

La presente investigación tiene por objeto determinar aquellos factores que aplazan la atención de los procedimientos administrativos en las municipalidades del departamento de La Libertad. Para ello, se ha analizado las quejas presentadas por ciudadanos ante la Defensoría del Pueblo contra diversas municipalidades (provinciales y distritales) del departamento de La Libertad por la demora en sus procedimientos administrativos; obteniendo como resultado que, los principales factores que aplazan los procedimientos administrativos en las municipalidades del mencionado departamento en Perú, son la carencia de prácticas de mejora en sus procesos de productividad y de gestión; lo que conlleva a concluir que las municipalidades no solamente vienen inobservando los lineamientos y obligaciones del Sistema de Modernización del Estado en cuanto a su estructura, organización y funcionamiento establecido en la Ley N.° 27658 “Ley Marco de Modernización de la Gestión del Estado” del 29 de enero del año dos mil dos; la Política Nacional de Modernización de la Gestión Pública, aprobada mediante Decreto Supremo N.° 004-2013-PCM, de fecha nueve de enero de dos mil trece, el Reglamento del Sistema Administrativo de Modernización de la Gestión Pública, aprobada por Decreto Supremo N.° 123-2018-PCM, de fecha 18 de diciembre del año dos mil dieciocho; sino también, el derecho fundamental de petición establecido en la vigente Constitución Política del Perú de 1993.
A APRENDIZAGEM AUTOGERIDA NOS CURSOS ON-LINE COM AJUDA DO DESIGN INSTRUCIONAL
Authors: Rodrigues Fábio Feitosa , Pullen Flaviani Costa dos Santos , Figueirôa Lindalva Mendonça de , Magalhães Márcio Santana , Santos Silvana Maria Aparecida Viana
Published: August 2023

O presente trabalho tem como objetivo analisar o aprendizado autogerido com ajuda do design instrucional e mostrar a importância do profissional de design instrucional que faz a diferença no desenho de uma estrutura de um curso levando o aluno a uma autonomia de estudo e pesquisa se enquadrando ao estudante do século XXI. A metodologia usada foi a pesquisa bibliográfica com autores da área de educação e tecnologia. Nos capítulos do artigo indicarei os benefícios da aprendizagem autogerida como também suas vantagens e desvantagens para o processo da aprendizagem. Em seguida vemos a importância do design instrucional na preparação do curso e o desafio de trazer o estudante ao estudo com várias estratégias e modelos de aplicação na plataforma de aprendizagem e na sequência mostrarei minha experiencia como aluno de cursos com aprendizagem autogerida e que me trouxe vários benefícios na minha vida profissional como a autonomia e disciplina nos estudos. A conclusão dessa análise é que os cursos on-line nos possibilitam vários benefícios e esse será o futuro.
GERAÇÃO “SCREENAGERS”
Authors: Costa João Elias Ferreira da , Meroto Monique Bolonha das Neves , Oliveira Rebeca Maria de , Santos Silvana Maria Aparecida Viana , Beck Viviane Aparecida Damian
Published: August 2023

A tecnologia tem o potencial de oferecer diversas oportunidades de aprendizado, acesso a informações e interação social, mas também apresenta desafios em relação à atenção, ao desenvolvimento cognitivo e ao uso excessivo desses dispositivos. Ante isso, o presente paper visa compreender como a presença constante da tecnologia afeta a formação educacional dos jovens, investigando tanto os benefícios quanto as limitações desse contexto, identificando estratégias pedagógicas que possam otimizar o uso da tecnologia na sala de aula, promovendo uma formação educacional mais completa e adequada às necessidades dessa geração. O procedimento metodológico adotado consiste em uma revisão bibliográfica abrangente, que inclui estudos e pesquisas sobre o impacto da tecnologia na educação, o desenvolvimento cognitivo dos jovens, os desafios enfrentados pelos educadores e as estratégias pedagógicas eficazes no contexto da geração de Screenagers. Os resultados encontrados indicam que a presença da tecnologia na formação educacional dos jovens da geração de Screenagers tem tanto benefícios quanto desafios. Por um lado, a tecnologia oferece acesso a informações diversificadas, estímulo à criatividade, interação social ampliada e personalização da aprendizagem. Por outro lado, é necessário lidar com questões como o uso excessivo das telas, a distração, a falta de habilidades socioemocionais e a necessidade de orientação e mediação adequadas por parte dos educadores. A conclusão deste trabalho ressalta a importância de uma abordagem equilibrada e consciente no uso da tecnologia na formação educacional dos jovens.
MOTIVAÇÃO DO ESTUDANTE NO AMBIENTE E-LEARNING
Authors: Carvalho Fabrísia Maria da Silva , Silva Liliane Inácia da , Siva Fabrício Cardoso da
Published: August 2023

A motivação é um fator importante que interfere na vida escolar do estudante, a fim de melhorar a aprendizagem. O presente paper apresentou uma pesquisa cujo objetivo geral é descobrir formas de motivar o estudante no ambiente e-learning, deixando-o atrativo. Porém, que estratégias podem ser usadas para realizar esta tarefa? E têm como objetivos específicos definir motivação; definir ambiente virtual de aprendizagem – AVA; e apresentar metodologias que promovem a motivação no e-learning. Para tanto, são necessários recursos tecnológicos que promovam a motivação no ambiente virtual de aprendizagem com uso de inteligência artificial - IA. As questões que deram norte ao desenvolvimento desta pesquisa bibliográfica foram um estudo teórico sobre motivação: conceitos e implicações, onde ficou claro o que é motivação e sua relevância; ambiente virtual de aprendizagem, onde ficaram evidentes conceitos e os elementos que faz parte deste ambiente; e, por fim, metodologias que promovem a motivação no e-learning, onde foram apresentadas estratégias que motivam o estudante, que são imprescindíveis e corroboram para a eficácia do ensino neste tipo de ambiente. Neste estudo, cuja metodologia é qualitativa, dialoga-se com autores sobre a importância destas questões citadas, que deram credibilidade às conclusões encontradas. Para o sucesso de um curso de ensino a distância -EaD é necessário um ambiente acolhedor, onde exista empatia e bom relacionamentos entre seus usuários, fazendo uso de recursos tecnológicos que fazem parte desse processo motivando e despertando o interesse.
Recaudación de impuestos y creación de valor empresarial en las empresas manufactureras de Cotopaxi
Authors: Moreno Tapia Lucía Margoth , Espinosa Moreno Erika Gissela , Caisachana Ortiz Cristian Gonzalo
Published: August 2023

En un entorno económico donde los impuestos son una fuente esencial de financiamiento gubernamental surge la cuestión de como las cargas tributarias descienden la capacidad de las empresas para generar valor económico sostenible. Por ello, el objetivo de la investigación radicó en analizar las determinantes de la estructura de capital a través del modelo de mínimo cuadrado ordinarios para determinación de la creación de valor de las empresas manufactureras de Cotopaxi. Para ello, se utilizó un diseño metodológico con un enfoque cuantitativo, ya que, se analizó estados financieros. Como muestra de estudio se eligió a 15 empresas de la provincia que cumplían con los requisitos para proceder al análisis previo. Al realizar un análisis correlacional se evidenció que fueron contrastados frente al EVA. Los resultados manifestaron que tiene un alto nivel de significancia el factor tamaño de la firma de las empresas. Por otro lado, el factor rentabilidad fue todo lo contrario, esto corrobora que a medida que un indicador incrementa el otro decrece. Se concluyó que es importante considerar que para futuras investigaciones se debería analizar la composición de los estados financieros para establecer cuál es su estructura y como se modifica en tiempos de crisis económica.
Kajian Normatif Lembaga Pemasyarakatan Padat Huni agar Warga Binaan menjadi Lebih Sehat dan Produktif sesuai Undang-Undang Nomor 12 Tahun 1995 tentang Pemasyarakatan
Authors: Jasher. P Heman , Neltje Saly Jeane
Published: August 2023

This thesis normatively examines Correctional Institutions that exceed their capacity by optimizing coaching and a healthy lifestyle that does not neglect the Human Rights, Business, Health and Digital aspects by using the economic principles of Professor Richard Allan Posner, Inmates who are mentally and psychologically healthy will easy to benefit from entrepreneurship coaching and training so as to make Human Resources better. It seems that the government has not been able to maintain proper capacity prisons accompanied by maximum guidance even though it has built prison buildings. This can be seen from the tendency of former convicts to repeat wrongdoing and re-enter the correctional institution. Relevant agencies, in this case law enforcers, need to integrate technical support for Correctional Institutions so that the Prisoners become physically and mentally healthy and productive, for example the Police, the Prosecutor's Office as well as the Courts with their role in supporting so that the prison capacity is livable of course by not forcing to process or ensnare, prosecute someone in cases where the criminal facts are not strong. Densely inhabited Correctional Institutions as a formulation of the problem are ensuring that inmates are able to make them healthier and more productive, ensuring that the lifestyle of the inmates prioritizes physical and mental health, ensuring coaching and work training accompanied by a healthy environment can make the personality of the inmates better in the future when he returned to live in the midst of society. Today's Industry 4.0 era is the time to technically support Correctional Institutions so that Prisoners in their activities will be digitally monitored in addition to the availability of surveillance cameras in every corner and finger scans when passing through various rooms so that 24-hour activities can be seen which will produce a digital recap which can be used as material for assessment or credit points for Prisoners to obtain additional remissions, Prisoners also have the opportunity to work outside the Penitentiary to develop their entrepreneurial understanding, have indirectly taken part in supporting industry 4.0. Furthermore, Prisoners who are free can certainly develop their skills in the community.
Rendición de cuentas y aprendizaje en niñez y adolescencia salvadoreña
Authors: Marroquín-Vanegas Paola , Pérez-Hernández Lisandro
Published: August 2023

En El Salvador, los niños, niñas y adolescentes representan una parte significativa de la población que se beneficia de diversos proyectos de desarrollo ejecutados por Organizaciones No Gubernamentales (ONG). Este artículo investiga la visibilidad que las ONG otorgan a este segmento de la población en sus páginas web, especialmente en cuanto a su participación en los diferentes mecanismos de rendición de cuentas y aprendizaje. Utilizando un enfoque cualitativo y una metodología descriptiva, se examinó si las mencionadas entidades cumplen con las nueve categorías de análisis establecidas en la Guía MEAL DPro. Los resultados y hallazgos revelaron que las ONG incorporan a los titulares de derechos en los procesos de rendición de cuentas y aprendizaje. Esta inclusión no solo promueve prácticas eficaces que refuerzan la cultura organizacional de las entidades, sino que también legitima su trabajo
Hukum Taurat Menurut Rasul Paulus Dan Relevansinya
Authors: Hutagalung Pitta Uli , Sinaga Krisda Mahdalena
Published: August 2023

The law is God's commandment that shows His love and will. For this reason, the law becomes something that is important to be applied in the lives of God's people. However, it seems that there are contradictions regarding the law in Paul's letters both among theologians and people in general, giving rise to various interpretations. This diversity of interpretations raises questions about what the true essence of the law is that can still be relevant for God's people to apply today. Therefore, this article wants to describe the theological meaning of the law in Paul's writings that are relevant to the practical application of God's people today. This effort is carried out by the author by reviewing the background of some of Paul's letters which describe the law, so that he can further extract the theological values of the law contained therein. Through this, it can be understood that the law is practically relevant today by understanding that the law is all forms of feelings and actions that emanate from the heart to manifest love for God and others
Polymorphism of interleukin control genes and risk of neoplasms in exposed individuals
Authors: Blinova EA , Yanishevskaya MA , Akleyev AV
Published: August 2023

Factors of the immune system, including secreted pro-inflammatory interleukins, enable tumor control. However, against the background of prolonged chronic inflammation, they can trigger oncogenesis. Polymorphic variants in the coding and regulatory regions of cytokine genes can affect gene expression, mRNA stability, structure and activity of the protein product, with consequences on the levels of cells and body as a whole. This study aimed to search for the relation between polymorphic variants of interleukin genes IL1b (rs1143634), IL2 (rs2069762), IL4 (rs2070874), IL6 (rs1800795), IL8 (rs4073), IL10 (rs1800871) and risk of cancer, and to analyze the effect of polymorphic loci on concentration of serum interleukins. The study involved 585 persons chronically exposed to radiation. We established association of polymorphic IL4 site (rs2070874) with concentration of serum IL4 in individuals with chronic low dose-rate exposure of the red bone marrow 1.17 to 3507 mGy (mean value — 566 mGy). The content of serum IL4 in people with C/T and T/T genotypes (as per the dominant model) was significantly lower than in those with C/C genotype (p = 0.02). Polymorphic sites rs1143634, rs2069762, rs2070874, rs1800795, rs4073, rs1800871 were not found to be associated with the risk of malignant neoplasms in exposed individuals.
The Effect of Using Crude Papain as Coagulant on Chemical Characteristics and Energy Value of Susu Goreng Made from Cow’s Milk
Authors:   Faculty of Animal Husbandry Marine and Fisheries, Universitas Nusa Cendana, Hikmat Dea Ananda , Sabtu Bastari ,   Faculty of Animal Husbandry Marine and Fisheries, Universitas Nusa Cendana, Noach Yakob R. ,   Faculty of Animal Husbandry Marine and Fisheries, Universitas Nusa Cendana, Armadianto Heri ,   Faculty of Animal Husbandry Marine and Fisheries, Universitas Nusa Cendana
Published: August 2023

This study aimed to determine the effect of crude papain on the chemical characteristics and energy value of fried milk made from cow’s milk. A completely randomized design (CRD) was used in this experiment with 4 treatments and 4 replicates. The levels of crude papain tested were P1 = 0.5%, P2 = 1%, P3 = 1.5% and P4 = 2.0%, of milk volume. The variables studied included protein content, total sugar, lactose, calcium and energy value. The collected data were processed according to the variance analysis procedure. The fried milk produced had protein content; 9.9 – 11.87%, fat 6.59 – 9.59%, lactose 4.84 – 8.72%; total sugar 28.25 – 36.75%; calcium 0.23 – 0.26% and energy value 2712.47 – 3388.25 calories/100g. The results of variance analysis showed that the treatment had a very significant effect (P<0.01) on fat content, total sugar, and a significant effect (P<0.05) on lactose content, but not significant (P>0.05) on protein, calcium, and energy value of fried milk. It was concluded that the use of crude papain produced fried milk with varying levels of fat, total sugar and lactose but protein, calcium and energy value tended to be the same. The best results were obtained with the use of crude papain 0.5%.
The Effect of Crude Papain as Coagulant on Chemical Characteristics and Energy Value of Susu Goreng Based On Goat’s Milk
Authors:   Fakultas Peternakan Kelautan dan Perikanan, Universitas Nusa Cendana, Jl. Adisucipto Penfui, Kupang, Nusa Tenggara Timur, 85001, Pandie Dwita D. P. , Noach Yakob R. ,   Fakultas Peternakan Kelautan dan Perikanan, Universitas Nusa Cendana, Jl. Adisucipto Penfui, Kupang, Nusa Tenggara Timur, 85001, Sabtu Bastari ,   Fakultas Peternakan Kelautan dan Perikanan, Universitas Nusa Cendana, Jl. Adisucipto Penfui, Kupang, Nusa Tenggara Timur, 85001, Armadianto Heri ,   Fakultas Peternakan Kelautan dan Perikanan, Universitas Nusa Cendana, Jl. Adisucipto Penfui, Kupang, Nusa Tenggara Timur, 85001
Published: August 2023

Experiment aimed was determined the influence of using crude papain as coagulant on the chemical properties and energy value of susu goreng based on goat milk. The completely randomized design (CRD) with 4 treatments and 4 replications was applied in this experiment. The crude papain levels tested consist of P1= 0.5%, P2= 1.0%, P3= 1.5% and P4= 2.0% of milk volume. The variables measured was moisture, protein, fat, total sugar, lactose, calcium and energy value. Susu goreng obtained has moisture ranged of 52.99 to 54.08%; protein 24.88 to 29.05%; fat 22.30 to 25.75%; lactose 0.69 to 1.38%; total sugar 2.72 to 4.4%; calcium 0.68 to 0.77% and energy value 1989.28 to 2507.09 kcal/100 g. Analysis of variance showed that treatment had close significant effect (P<0.01) on total sugar, calcium and lactose, significant (P<0.05) on energy value but had no significant (P>0.05) on moisture, protein and fat. It can be concluded that the use of crude papain as a coagulant with a level of 0.5 to 2% produces susu goreng with varying chemical characteristics. The use of crude papain level 0.5% is the best where the susu goreng produced has the characteristics of the higher protein content, calsium and energy value, the lowest lactose content and total sugar.
Usos e ocupação do solo
Authors: Falk dos Santos Isabella , Ribeiro Botechia Flávia
Published: August 2023

Este artigo se desenvolve a partir das considerações de que a apropriações nos espaços públicos urbanos está relacionada com os usos e ocupações do solo urbano, e que, a leitura do aspecto edificado do tecido urbano é chave de interpretação para as relações que se estabelecem nos espaços públicos. O principal objetivo é apresentar a influência do uso e ocupação do solo na apropriação do entorno da praça Regina Frigeri Furno, em Vitória-ES. Para tanto, o estudo de caso divide-se em três partes, sendo que a primeira busca estabelecer e entender os períodos de consolidação do tecido urbano em questão; a segunda parte corresponde a análise tipo-morfológica do entorno imediato à praça; e, por fim, a terceira demonstra as relações de apropriação do espaço público com os edifícios do entorno da praça. Como resultado, foi possível demonstrar as considerações iniciais da pesquisa, sendo que, as atividades comerciais e de prestação de serviços, ao lado da própria constituição do tecido urbano, influenciaram nas dinâmicas observadas de apropriação dos espaços públicos.
Cálculos teóricos como ferramenta complementar para a elucidação estrutural do novo alcaloide pirrolizidínico isolado de crotalaria paulina
Authors:   , Baia Vitor da Cunha
Published: August 2023

A área de produtos naturais tem sido alvo de muitas pesquisas envolvendo isolamento, caracterização e quantificação de substâncias bioativas, com potenciais aplicações na indústria farmacêutica e agroquímica. Um dos desafios encontrados nos estudos de produtos naturais é a identificação estrutural dos compostos orgânicos constituintes, muitas vezes de difícil interpretação pelos métodos espectroscópicos tradicionais. Por isso, existem relatos de estruturas assinaladas erroneamente na literatura e que necessitam de revisão. Embora a ressonância magnética nuclear (RMN) seja uma das ferramentas mais poderosas utilizadas para a elucidação estrutural, ainda existem limitações associadas à purificação da amostra, erros sistemáticos e moléculas complexas que demandam o auxílio de protocolos complementares para a correta identificação. Neste sentido, a química computacional se apresenta como uma ferramenta útil para os químicos orgânicos, permitindo o estudo de parâmetros de RMN através de cálculos teóricos, com obtenção de dados calculados que podem ser comparados com os dados experimentais da molécula estudada. Vários métodos estatísticos são encontrados na literatura para avaliar a qualidade do ajuste dos dados, como o CP3, DP4 e DP4+. Enquanto o método CP3 analisa dois conjuntos de dados experimentais com duas estruturas candidatas, os métodos DP4 e DP4+ analisam um conjunto disponível de dados experimentais com duas ou mais estruturas candidatas, indicando aquela que mais se aproxima dos dados experimentais. Esse trabalho descreve detalhadamente a elucidação estrutural de um novo alcaloide pirrolizidínico (AP) isolado da planta Crotalaria paulina, com o auxílio de experimentos de RMN e cálculos teóricos, envolvendo a Teoria do Funcional da Densidade (DFT) e o método estatístico DP4+. Oito possíveis estereoisômeros para o AP foram avaliados por meio dessas ferramentas, indicando que a etilmetilcrotalina (estrutura candidata 3) é a estrutura correta para esse produto natural. Palavras-chave: Elucidação estrutural. Produtos naturais. Química computacional. Cálculos teóricos. Crotalaria paulina.
Avaliação da resistência da cana-de-açúcar frente à praga broca da cana (Diatraea saccharalis) utilizando análises cromatográficas e modelos quimiométricos de classificação a partir de dados espectroscópicos
Authors:   , Diniz Mariana Beatriz Teixeira
Published: August 2023

Desde sua adaptação em solo brasileiro, a cana-de-açúcar sempre foi parte da economia do país, chegando a produzir mais de meio bilhão de toneladas por safra nos últimos anos. Apesar de ser uma cultura bem estabelecida nas nossas condições climáticas, seu cultivo pode ser afetado por diversos fatores, sendo um deles a infestação de pragas como as larvas da mariposa Diatraea saccharalis (broca da cana). Entretanto, alguns genótipos desenvolvidos com melhoramento genético apresentam resistência ao ataque da broca. Neste trabalho, foi feita a identificação de 28 compostos presentes na cera de folhas de cana-de-açúcar e um dos compostos identificados (friedelina) foi quantificado. Os teores de friedelina se mostraram diferentes na maioria dos genótipos resistentes e suscetíveis. Os genótipos resistentes apresentaram teores de friedelina superiores a 0,35 g em 100 g de cera, com exceção de dois genótipos que apresentaram concentrações de friedelina abaixo desse valor. Nos genótipos suscetíveis, o teor de friedelina observado foi inferior a 0,26 g a cada 100 g de cera, ou não foram detectados. Neste trabalho, também foi desenvolvido um modelo de classificação, quanto à resistência dos genótipos com base em espectros de infravermelho próximo obtidos das folhas da cana-de-açúcar. Para isso, foi utilizado o método quimiométrico de quadrados mínimos parciais para análise discriminante (Partial Least Squares Discriminant Analysis, PLS-DA) juntamente com um método de seleção de variáveis chamado “Seleção de Preditores Ordenados” (OPS). O modelo desenvolvido foi capaz de classificar corretamente os genótipos resistentes e suscetíveis com 11 meses após o plantio em campo, sendo sua principal vantagem não necessitar de etapas de preparo de amostra e ser um método não destrutivo. Além disso, também foi feito um bioensaio com larvas da broca da cana, onde foi oferecida uma dieta contaminada com concentrações compatíveis de friedelina encontradas na cera das folhas da cana. Este ensaio foi realizado para investigar se as concentrações de friedelina que foram encontradas eram responsáveis pela resistência exibida por alguns genótipos. As larvas foram acompanhadas durante sete dias e a maior taxa de mortalidade observada foi de 62,5%. Além disso, também foi observado um déficit de desenvolvimento nas larvas que ingeriram a dieta contaminada com friedelina em relação ao grupo de controle. Com isso, foi possível concluir que a friedelina faz parte do mecanismo de resistência desses genótipos, embora possa não ser o único. Palavras-chave: Cromatografia gasosa. Quimiometria. Cana-de-açúcar. Broca da cana. Friedelina.
Contracts for the Sale of Goods: Passing of Property in Goods Under the Law of the United Kingdom and Ghana
Authors: Obiri-Korang Prince
Published: August 2023

A contract for the sale of goods is the most commonly used transaction domestically and at international level. Regardless of its relevance, there has been a wide variation in the concept of “sale” has existed in the course of legal history across the various legal systems of the world. Although a sales transaction may be rightly described as the most universal transaction, it is pertinent to point out that there is very little agreement on one of the transaction’s most fundamental incidents, which is the “passing of property”. In most legal systems, aside from the generally established rule on when the property in goods may pass from a buyer to a seller, property in goods can also pass at any time depending on the circumstances or terms of the relevant contract. Despite the above proposition, it is important for all persons who engage in a sale transaction to have an understanding as to when the property in the goods that they intend to purchase or that they have purchased passes from the seller to them. This article primarily focuses on when property passes in a sale contract in the legal systems of the UK and Ghana. This is relevant because when a buyer enters a sale contract, it is the property in the goods that they bargain for and not the use or mere possession or any other aspect of ownership.
Towards an Appropriate Legal Framework for Sustainable Management and Disposal of Plastic Waste in Nigeria: Lessons from Other Jurisdictions
Authors: Egeruoh-Adindu Izuoma
Published: August 2023

Plastic pollution from unsustainable management and disposal of plastic waste on land and in the marine environment is a very serious problem. Statistics indicate that more than one million plastic bags are used every minute, and approximately 500 billion plastic bags are used annually worldwide. This phenomenon has raised global concern leading to the adoption of measures by countries, including legislation to mitigate plastic waste pollution in the environment. Employing desk-based research methodologies, this paper examines the problems associated with the indiscriminate disposal of plastic waste in Nigeria. The paper argues that the extant legal framework on the management of solid wastes is ineffective, too general and does not take cognisance of the peculiarities and environmental hazards associated with plastic waste. The paper concludes that an appropriate legal framework complemented by effective enforcement mechanisms that target plastic waste management and sustainable disposal are required to address the problem. This paper, therefore, calls for the passage of the Plastic Bag (Prohibition) Bill of 2018 before the National Assembly and the effective implementation of the recommended measures aimed at ensuring environmentally-friendly disposal of plastic waste in Nigeria.
Calidad de servicio en el proceso de admisión. Un enfoque práctico para la gestión de la calidad
Authors: Rojas Bujaico John Fredy , Gutiérrez Martínez Fredi , Rojas Bujaico Rafael Wilfredo , Pacheco Moscoso Luis Enrique , Arias Valenzuela Edverd Nilton , Huamán Samaniego Héctor
Published: August 2023

La calidad del servicio ha sido, por mucho tiempo, un indicador significativo en el éxito y el posicionamiento adecuado de cualquier organización. En contextos educativos, particularmente en el proceso de admisión, este aspecto cobra especial relevancia. Los estudiantes potenciales y sus familias buscan instituciones que ofrezcan experiencias claras, ágiles y efectivas desde el primer contacto.
Por ello, la propuesta de los autores de: CALIDAD DEL SERVICIO EN EL PROCESO DE ADMISIÓN: UN ENFOQUE PRÁCTICO PARA LA GESTIÓN DE CALIDAD, resulta de gran significado. Es la consideración de conceptos que persiguen su aplicabilidad en el ámbito de las Instituciones educativas modernas; prestas a la adaptación a los constantes cambios en las expectativas y demandas de la sociedad actual.
A través de sus capítulos, esta publicación explorar los fundamentos sobre la calidad del servicio aplicada a la gestión de admisión estudiantil. En este sentido, los lectores descubrirán:
CAPÍTULO 1: Una inmersión en la relevancia de un servicio de calidad durante el proceso de admisión, sienta las bases para comprender su impacto en el mundo académico.
CAPÍTULO 2: Profundiza en los principios esenciales de la calidad de servicio, estableciendo un fundamento teórico para los capítulos subsiguientes.
CAPÍTULO 3: Aborda cómo estos principios se manifiestan específicamente en los procedimientos de admisión, ofreciendo pautas y ejemplos para su implementación.
CAPÍTULO 4: Aporta herramientas y métodos para medir y evaluar la calidad del servicio en admisión, esencial para mantener y mejorar los estándares.
CAPÍTULO 5: A través del análisis de diferentes casos de estudio, el lector podrá reflexionar sobre las experiencias exitosas y cómo estas estrategias se han implementado en diferentes contextos.
CAPÍTULO 6: Concluye con una visión hacia el futuro, destacando la importancia de la mejora continua y ofreciendo perspectivas renovadas para quienes buscan elevar la calidad de sus procesos de admisión.
Esta obra no sólo es una guía teórica, sino también una invitación a reconsiderar y redefinir la calidad del servicio en el ámbito educativo, con el fin de ofrecer a los estudiantes y sus familias experiencias excepcionales desde el primer contacto. Una lectura muy productiva para líderes y gestores de instituciones educativas que buscan la excelencia en su servicio.
Dr. Franklin Salas AularORCID: https://orcid.org/0000-0001-6071-6455
Editor ACVENISPROH EDICIONES
The application of Neural Prophet Time Series in predicting rice stock at Rice Stores
Authors: Hindarto Djarot , Hendrata Ferial , Hariadi Mochamad
Published: August 2023

Efficient inventory management and consistent rice supply are pivotal for the sustainability of small-scale food stalls. This research introduces an innovative approach to address this challenge through the Neural Prophet algorithm. By synergizing neural networks with additive regression models, the Neural Prophet captures intricate temporal patterns and trends within rice sales data. Our study evaluates the Neural Prophet's effectiveness in predicting rice sales, specifically for essential food vendors. Leveraging historical sales data from June 2022 to April 2023, the algorithm incorporates seasonality and trends and integrates external events, such as holidays, to heighten prediction precision. Our findings underscore the Neural Prophet's remarkable prowess in forecasting rice sales at primary food kiosks, adeptly discerning data trends and fluctuations, culminating in reliable future sales projections. The model boasts compelling performance metrics: MAE = 12.90, RMSE = 15.80, and Loss = 0.0313. Beyond its technical merits, this research carries significant practical implications, empowering proprietors and suppliers of basic food stalls to streamline inventory management, avert stockouts, and curtail overstocking by harnessing the precision of rice demand forecasting facilitated by the Neural Prophet algorithm.
Audit Committee Attributes and Sustainability Reporting of Oil and Gas in Nigeria
Authors: Toluwa Ohidoa , Joseph Oseikhuemhen OJEAGA
Published: August 2023

This study investigates the effect of audit committee attributes and sustainability reporting. The study covered the range of nine (9) years period (2014 – 2022). Mainly, secondary data were pooled from annual reports of the sampled companies listed at floor of Nigeria group exchange as at 31st December 2021 financial year end. Data collected were subjected to polled panel regression analysis estimation. The outcome of statistical results, revealed that audit committee size has a negative and significant impact on sustainability reporting; audit committee independence and audit committee meeting have a negative but insignificant impact on sustainability reporting; and audit committee multiple directorship was found to have a positive and significant impact on sustainability reporting. This study, therefore recommends that audit committee size and composition should be established in line with the relevant provisions of the law; a minimum of one audit committee member should have interlocking directorship in order for companies to gain from the extended knowledge wider channel networks and broader experience that these members gain from serving on different board.
Technology for Predictive Health Monitoring of Elderly and Vulnerable Citizens in Kenya using Healthcare 4.0: A Theoretical Review
Authors: Barasa Samuel , Etene Yonah
Published: August 2023

The traditional critical healthcare planning is based on periodic routine checks and a reactive strategy of interventions whenever the individuals have entered high risk states (such as heart attacks or strokes). The Healthcare 4.0 design is based on the principle of continuous predictive health monitoring such that the buildup process towards high risk states of individuals can be identified much before their critical levels thus ensuring proactive interventions by the hospitals. Kenya has significant potential to adopt Healthcare 4.0 technology using traditional information and networking components. This research investigates how Healthcare 4.0 can be used in predictive health monitoring of the elderly and vulnerable citizens that individual hospitals can adopt for operational excellence. Desktop review methodology was used. The technical literature review was used to define an operations algorithm. The results suggest that several customizations are needed in the traditional information and networking components to make them fit for predictive health monitoring. The individuals under critical monitoring should not be allowed high mobility as it has a negative effect on monitoring reliability and effectiveness. Healthcare 4.0 adoption in Kenya is feasible. Its operational details need to be defined with several tiers of customized solutions for different patient classes. There are some limitations found in this research, which should be kept in mind while designing and operating Healthcare 4.0 networks in Kenya.
Predictive Health Monitoring of Multimorbidity: A Simulation Experiment Using OPNET Modeller
Authors: Barasa Samuel
Published: August 2023

Primary health care services are increasingly at the heart of integrated people-centred. They provide an entry point into the health system, ongoing care coordination and a person focused approach. Patient safety incidents involve active events, such as adverse drug events, intervention complications, infections and care failures, prescribing and delayed diagnosis. As a result, patients with multimorbidity are at higher risk of safety issues. In this study, monitoring is conducted on data streams from wearable body sensors enabled by Healthcare Internet of Things, overlapping time series plotting of body parameters, and a rules-based decision engine with artificial intelligence capabilities to detect risky patterns of variations in the body parameters. This research investigates a possible design for predictive health monitoring of multimorbidity that individual hospitals can implement at low costs and high operations effectiveness and feasibility. This research was conducted in OPNET modeller to: (a) Conduct simulation-based testing of a low-level Healthcare 4.0 design for monitoring of multimorbidity; (b) Suggest practical design, operational details, and limitations for predictive health monitoring of multimorbidity. The design details were captured from literature and the simulated design was created for monitoring 105 health sensors by a single hospital in its vicinity of 10 Kilometers radius. The design comprised of edge computing servers in the hospital’s premises connected to a fog computing system for running body area networks of body-attached sensors of 100 individuals. The connections between the edge computing servers and the fog computing system were 100 Mbps broadband Internet connections on Optical Fiber. The simulation was conducted to study effects of mobility of the citizens, effects of TCP session and transmission delays, effects of buffering in the WLAN routers, and effects of TCP congestion windows. The simulation pattern was defined by an operations algorithm designed with the help of technical literature review. The WLAN routers should have high capacity of buffer memories to temporarily store health data streams and large number of receiving channels to avoid information losses. The TCP session timeouts and congestions can be very harmful for individuals being monitored critically. Hence, bandwidth allocation to body area networks should be planned based on the frequency and amount of data needed by the hospitals. The body area networks deployed on individuals should have carefully conducted right sizing of number of parameters, their data volumes, transmission frequencies, and criticality of the individuals. The hospitals should classify patients in different classes based on criticality, data volumes, and frequencies of monitoring needed, and allocate appropriate multi-tiered body area networks for the different patient classes. A one size fit for all approach will fail.
Advancing Efforts and Strategies to Stop Female Genital Mutilation/Cutting (Fgm/C) in South-East Nigeria: A Qualitative Approach
Authors: Ikonne Ogadinma
Published: August 2023

This study focused on advancing efforts and strategies to stop Female Genital Mutilation/Cutting (FGM/C) in South-East Nigeria using a qualitative approach. The specific objectives included: to find out efforts made towards eliminating FGM/C in South-East Nigeria; and to identify how the practice of FGM/C can be eradicated in South-East Nigeria. The study was anchored on the social norms theory and it is purely qualitative. A combination of purposive sampling, cluster sampling and simple random sampling techniques was adopted to select respondents for this study. A total of 54 interviews were conducted across 9 qualitative population categories in 6 communities in South-East Nigeria. The QDA Miner software was used to analyze the data. The findings showed that a number of efforts have been made to stop FGM/C in South-East Nigeria which include lecture/campaigns/sensitization, health worker education of community members, punishing the offenders and skeletal involvement of men in FGM/C-eradication campaigns. Again, FGM/C can be eradicated in South-East Nigeria especially through the intensification of such culturally specific/grassroots oriented strategies already existent in the communities such as community sensitization/education, community sanctioning and male-targeted FGM/C-eradication campaigns. It was concluded that it is only the strategies that are culturally specific/grassroots oriented that can bring about FGM/C-eradication but must not be fluidly applied. It was therefore recommended that Government and Non-Governmental Organizations should intensify the already existing sensitization efforts towards the eradication of FGM/C in South-East communities.