bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Return On Equity (ROE), Debt To Equity Ratio (DER), Dan Price Earning Ratio (PER) Terhadap Return Saham Pada Perusahaan Infrastruktur, Utilitas dan Transportasi di Daftar Efek Syariah Periode 2017-2018
Authors: Zayyinah Zayyinah , Firmansyah Farid
Published: November 2021

Daftar Efek Syariah (DES) adalah kumpulan efek yang tidak bertentangan dengan prinsip-prinsip syariah di pasar modal, dan ditetapkan oleh Bapepam-LK atau pihak yang disetujui Bapepam-LK. Perusahaan yang terdaftar di Daftar Efek Syariah yaitu perusahaan Infrastruktur, Utilitas dan Transportasi. Besar kecilnya perolehan Return tergantung sistem kinerja manajemen perusahaan. Semakin tinggi peningkatan Return perusahaan semakin baik kinerja perusahaan. Prediksi Return Saham ini dapat dilakukan dengan menganalisis laporan keuangan berdasarkan rasio keuangan. Tujuan dalam penelitian ini yaitu untuk menganalisis Return On Equity, Debt to Equity Ratio, dan Price Earning Ratio secara simultan dan parsial berpengaruh signifikan atau tidak terhadap Return Saham pada perusahaan Infrastruktur, Utilitas dan Transportasi di Daftar Efek Syariah Periode 2017-2018. Penelitian ini menggunakan pendekatan kuantitatif, dengan teknik analisis linear berganda dengan bantuan alat analisis SPSS versi 20. Jenis data yakni data sekunder sampelnya 66 laporan keuangan dan pembuktian hipotesisnya menggunakan perhitungan uji F, uji t dengan melakukan uji asumsi klasik terlebih dahulu untuk mengetahui data regresi yang digunakan berdistribusi normal. Hasil uji asumsi klasik menunjukkan data regresi normal. Hasil penelitian menunjukkan bahwa variabel Return On Equity dihilangkan karena terdapat masalah pengujian dalam penelitian ini. Jadi hanya variabel Debt to Equity Ratio, dan Price Earning Ratio yang digunakan dan memperoleh hasil Debt to Equity Ratio, dan Price Earning Ratio secara simultan berpengaruh signifikan terhadap Return Saham. Hal ini dapat dilihat dari hasil uji F, nilai signifikan lebih kecil dari α = 0,05 yaitu 0,000. Hasil penelitian menunjukkan bahwa Debt to Equity Ratio berpengaruh negatif dan signifikan terhadap return saham dilihat dari nilai signifikan 0,000 < 0,05. Price Earning Ratio tidak berpengaruh signifikan terhadap return saham dapat dilihat nilai signifikansi 0,149 > 0,05. Berdasarkan tabel koefisien determinasi (r2) bahwa Adjust R Square adalah adalah 0,818 atau 81,8%. Hal ini berarti sebesar 81,8% kemampuan model regresi pada penelitian ini dalam menerangkan variabel dependen. Artinya 81,8% variabel Return Saham dijelaskan oleh variabel variasi variabel independen Debt to Equity Ratio dan Price Earning Ratio sedangkan sisanya (100% - 81,8%) 18,2% dipengaruhi oleh faktor-faktor lain diluar variabel yang diteliti
Efisiensi Emiten Properti dan Real estate yang Terdaftar di Indeks Saham Syariah Indonesia Tahun 2016-2020
Authors: Fresma Sari Indah , Effendi Jaenal
Published: November 2021

This study aims to analyze the efficiency of property and real estate issuers listed in the Indonesia Sharia Stock Index (ISSI) during 2016-2020 period and the factors that influence it. In the first stage, the researcher analyzes the efficiency value of property and real estate issuers using Data Envelopment Analysis (DEA) method. In the second stage, the researcher analyzes the factors that influence the efficiency value of property and real estate issuers by using tobit regression. There are 16 issuers used in this study. The results showed that none of the issuers consistently achieved the perfect technical efficiency score (the efficiency score is equal to 1) during the study period. The same thing happened to the pure technical efficiency analysis and the efficiency scale results. The results of the tobit model regression showed that the Return on Assets (ROA) has significant positive effect and the exchange rate (LNKURS) has significant negative effect on the efficiency value of property and real estate issuers. Meanwhile, the Debt to Asset Ratio (DAR), company size (LNSIZE), and interest rate (BIRATE) do not have significant effect on the efficiency of property and real estate issuers.
Pengaruh Profesionalisme, Indepensi, dan Kompetensi Auditor Terhadap Kualitas Audit di Badan Pendapatan Pengelolaan Keuangan dan Aset Daerah
Authors: Nisa Imami Khoirun , Kutsiyah Farahdilla , Hasti Priyadi Ira
Published: November 2021

Penelitian ini menggunakan pendekatan kuantitatif dengan tiga variabel independen yakni profesionalisme, independensi dan kompetensi  serta satu variabel dependen yakni kualitas audit. Sampel dalam penelitan ini yaitu 30 responden yang berada di Badan Pendapatan Pengelolaan Keuangan dan Aset Daerah Kabupaten Sumenep dan menggunakan analisis linier berganda. Jenis data yang digunakan adalah data primer yaitu penyebaran kuesioner. Analisis data dalam penelitian ini menggunakan software IBM SPSS Statistic 20.  Hasil penelitian ini menunjukkan bahwa: Pertama, profesionalisme secara parsial tidak berpengaruh terhadap kualitas audit dengan thitung -0,573 < ttabel 2,056 dan signifikansi 0,572 > 0,05. Indepedensi secara parsial berpengaruh terhadap kualitas audit dengan thitung 2,088 > ttabel 2,056 dan signifikan 0,047 < 0,05. Kompetensi secara parsial berpengaruh terhadap kualitas audit dengan thitung 2,116 > ttabel  2,056 dan signifikan 0, 044 < 0,05. Kedua, profesionalisme, indepedensi dan kompetensi secara simultan berpengaruh terhadap kualitas audit dengan fhitung 10,341 > ftabel 2,96. Ketiga, kualitas audit dipengaruhi oleh profesionalisme, indepedensi dan kompetensi hanya sebesar 54,4% sedangkan sisanya 45,6% dipengaruhi oleh variabel lain yang belum diteliti dalam penelitian ini.
Model tests of a marine diesel engine powered by a fuel-alcohol mixture
Authors: Zacharewicz Marcin , Kniaziewicz Tomasz
Published: November 2021

The paper presents the results of model and empirical tests conducted for a marine diesel engine fueled by a blend of n-butanol and diesel oil. The research were aimed at assessing the usefulness of the proprietary diesel engine model in conducting research on marine engines powered by alternative fuels to fossil fuels. The authors defined the measures of adequacy. On their basis, they assessed the adequacy of the mathematical model used.
The analysis of the results of the conducted research showed that the developed mathematical model is sufficiently adequate. Therefore, both the mathematical model and the computer program based on it will be used in further work on supplying marine engines with mixtures of diesel oil and biocomponents.
Rethinking the Choosing Wisely Portugal Recommendation on Breast Cancer Screening
Authors: Heleno Bruno , Viegas Dias Catarina , Martinho Clarisse , Jacinto Nuno , Cadinha Luís , Santos Paulo
Published: November 2021

N/a.
Intensive Care for COVID-19 Patients with Severe Mental Illness: A Call for Debate
Authors: Moura Diana , Vieira e Brito Nuno , Cabral Ana , Gouveia João
Published: November 2021

N/a.
Analisis Dampak Inovasi Layanan Perizinan Pada Dinas Penanaman Modal Dan Pelayanan Terpadu Satu Pintu (DPMPTSP) DKI Jakarta (Service poin pelayanan perizinan Pasar Rebo)
Authors: Diana Bambang Agus , Aulina Refita
Published: November 2021

Untuk mewujudkan Pelayanan Prima kepada Masyarakat maka Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu( DPMPTSP) DKI Jakarta melakukan berbagai inovasi yang Penyelenggaraan melalui One Stop Service Policy (OSSP) ini merupakan salah satu kebijakan pemerintah Provinsi DKI Jakarta untuk memberikan pelayanan prima kepada masyarakat terutama pada pelayanan perizinan dan non-perizinan dengan pelayanan yang tepat, cepat, mudah, murah dan tranparansi. Inovasi selalu dimulai dengan kreativitas yaitu memulai dengan memikirkan hal-hal yang belum pernah ada. Proses mewujudkan hal yang baru ini disebut dengan inovasi (levitt). Sementara Gareth Jones inovasi sebagai suato proses dimana organisasi menggunakan keahlian dan sumberdaya untuk mengembangkan sistem produksi dan operasi sehingga mereka dapat memberi tanggapan atas tuntutan konsumen secara lebih baik.  Evert M. Rogers (Suwarno, 2008:9) Metode penelitian menggunakan metode penelitian kualitatif untuk membaca fenomena yang terjadi dalam kondisi sosial khususnya dampak inovasi DPMPTSP pada masyarakat. . Salah satu peran Biro Pelayanan dan Penanaman Modal Terpadu Satu Pintu Provinsi DKI Jakarta adalah meningkatkan peluang promosi dan investasi melalui penyederhanaan prosedur pelayanan perizinan dan nonperizinan yang tepat, cepat, sederhana dan murah.
Determinants of Persistent Organic Pollutants (POPs) Levels in Human Specimens: A Review
Authors: Zahira Farah , Lestari Kusuma Scorpia , Aris Ahmad Zaharin
Published: November 2021

Introduction: Numerous studies have been conducted regarding persistent organic pollutants (POPs) concentrations in human biological matrices such as blood, breast milk, urine, and hair that cause adverse health effects such as breast cancer, cardiovascular diseases, and type 2 diabetes. This study aimed to determine the POPs presence in human specimens in household settings. Discussion: A total of 28 articles were included in this study with the criteria published in 2016- 2021, original research articles, free full text available, and studied at least one of the confounding variables of POPs levels in human specimens. The narrative method was selected to synthesize this study. Grouping articles with similar results was carried out to respond to research questions. This study discovered that age, dietary habits, BMI, sex, race/ethnicity, smoking status, physical activities, residency, household dust, and industry emissions were associated with POPs levels in human specimens. Conclusion: This study concluded that each determinant could not affect the POPs levels in the human specimens on its own since those determinants are influenced by each other. Future research using systematic literature review and meta-analysis is therefore strongly advised.
Praktik Mom Shaming Oleh Netizen Indonesia Terhadap Selebritis Yang Melakukan Sharenting Di Media Sosial
Authors: Savira Annisa
Published: November 2021

This  research focuses on analyzing the practice of shaming mothers that occurred on the Instagram accounts of two celebrity mothers, Andien Aisyah and Rachel Vennya. Researchers raised this topic because mom shaming is a phenomenon that often occurs nowadays, but not many have conducted an in-depth investigation of mom shaming so that it affects knowledge and awareness of mom shaming's actions and the impact of mom shaming on a mother. Analysis of the practice of mom shaming is carried out using the textual analysis method, where the researcher interprets the text from the sharenting practices of celebrity mothers on their social media, mom shaming comments by Indonesian netizens in the comments column of their uploads, and also resolutions or feeds. The results of this study indicate that mom shaming is often accepted by celebrity mothers, in this case Andien Aisyah and Rachel Vennya, regardless of the parenting method applied. However, there are differences in mom shaming patterns from sharenting practices or how celebrity mothers are free from parenting on their social media pages regarding the persona of the celebrity mother. The results of this study also show the intention of giving mom shaming text by Indonesian netizens to celebrity mother, where the messages are mom shaming messages that express their thoughts and feelings on their social media pages.
Konvergensi Setengah Hati : Invasi Konten Media Sosial dalam Program Berita Televisi di TVOne
Authors: Lizetha Vivin , Prawadika Angga
Published: November 2021

Growth of technology give big impact to development and changes in mass media. Today, even though broadcast media like radio and television still have place in the heart of audience, however should be recognized that the existence of social media, it must be recognized that the existence of social media has a significant impact on media development. Mainstream media, especially television broadcast media, are starting to look for ways not to be abandoned by their audience. They began put in social media content into television programs. That happened on all shows in television programs. No exception in the news program on TVOne. Therefore, it is interesting to study how the transfer of social media content to television news programs is a way for TVOne to survive in the midst of the onslaught of social media. This research focuses on news programs on TVOne that take social media content into the show. We will use descriptive qualitative research using the case study method and use the political economy theory of the media.
Public Space, Community, and Enjoyment in Music Festival: The experiences of 2019 Jazz Traffic Festival audience in Surabaya
Authors: Marga Karyasih
Published: November 2021

This research focuses on the visitors' experience of the Jazz Traffic Festival (JTF) 2019 in Surabaya. This research then aims to know how the experience gained by the visitors in JTF with the genre expansion was incorporated despite its title as Jazz music Performances. This research uses case study method and descriptive-qualitative approach. The data in this research is obtained by observation and independent-interviews with four informants as visitors of JTF. The results of this study showed that each JTF visitors have a different experience due to the preference and purpose of attending the festival. JTF becomes a public space for visitors who are part of the urban community for several reasons. The visitors attend JTF for the entertainment, to escape from the routine, to build social interactions, and to actualize self-identity. in addition, the innovative effort of JTF in maintaining its existence by expanding to non-jazz music and market was apparently still enjoyed by the visitors.
Revisión de la Metodología para la Mejora de la Enseñanza Universitaria = Review of the Methodology for the Improvement of University Teaching
Authors: Gallego-Sánchez-Torija Jorge , García-Herrero Jesús , Bedoya-Frutos Cesar
Published: November 2021

El presente trabajo pretende indagar qué aspectos de la metodología del aprendizaje basado en retos resultan mejor valorados por parte de los alumnos y qué aspectos son susceptibles de mejora. Para ello se realiza una encuesta abierta. Se detecta que valoran especialmente la cercanía del planteamiento de la asignatura con la realidad profesional y el acompañamiento de los alumnos a lo largo del proceso de aprendizaje. La mitad considera que la carga de trabajo es adecuada, mientras que la otra mitad la considera excesiva. El resto de los aspectos mejor valorados son el enfoque de la asignatura y la innovación educativa. Las características y habilidades de los profesores reciben una valoración media; son peor valorados la coordinación con otras asignaturas, los recursos facilitados, las cuestiones organizativas y el excesivo número de alumnos en clase. Se concluye que la opinión de los alumnos es una ayuda inestimable para evaluar la metodología utilizadaAbstractThe present work aims to investigate which aspects of the challenge-based learning methodology are best valued by students and which aspects are susceptible to improvement. For this, an open survey is carried out. It is detected that they especially value the closeness of the approach to the subject with the professional reality and the accompaniment of the students throughout the learning process. Half consider the workload adequate, while the other half consider it excessive. The rest of the best valued aspects are the focus of the subject and educational innovation. The characteristics and abilities of the teachers receive an average evaluation; Coordination with other subjects, the resources provided, organizational issues and the excessive number of students in class are less valued. It is concluded that the opinion of the students is an invaluable help to evaluate the methodology used.
Aplicación de la técnica puzle como estrategia de aprendizaje cooperativo en ingeniería sísmica = Jigsaw method application as cooperative learnig strategy in earthquake engineering
Authors: Galé-Lamuela David , González-Sanz Guillermo , Benavent-Climent Amadeo
Published: November 2021

La técnica de puzle es un método de aprendizaje cooperativo ampliamente implementado en ámbitos académicos que ha demostrado su eficacia en la adquisición de competencias fundamentales y transversales en la formación. La organización en grupos pequeños favorece la interacción entre alumnos y la división del trabajo en tareas separadas, fomentando la interdependencia positiva, característica fundamental en el aprendizaje cooperativo. Este trabajo presenta la aplicación de la técnica puzle a un bloque de la asignatura “Seminarios” del Máster en Ingeniería Sísmica de la Escuela Técnica Superior de Ingenieros Industriales de la Universidad Politécnica de Madrid. Tras su aplicación, se observa que el alumno adquiere de forma muy satisfactoria los contenidos de la materia, así como una mejora sustancial en la formación en competencias transversales y en el desarrollo de habilidades sociales. Los resultados positivos de esta experiencia ponen de manifiesto la necesidad de fomentar la implantación de metodologías docentes innovadoras en las enseñanzas técnicas universitarias.AbstractCooperative jigsaw method is widely spread in academic environments and it has demonstrated its efficiency on the acquisition of professional and transversal competences. The organization in small groups improves the interaction between students and the work partitioning in independent tasks, promoting the positive interdependence which is crucial for cooperative learning. The present study applies the jigsaw method to the “Seminars” course from MScs in Earthquake Engineering at Universidad Politécnica de Madrid. As a result of the application of this method, it is observed that the students learn the content of the subject, and improve substantially the transversal competences and social skills. This study supports the need of implementing innovative educational methods in the technical studies
ANALISIS FAKTOR YANG MEMPENGARUHI INDEKS HARGA KONSUMEN
Authors:   Universitas Islam Indonesia, Ganessa Nabila , Alphenia Sheilta ,   Universitas Islam Indonesia, Zanuarizqi Aisya ,   Universitas Islam Indonesia, Widodo Edy ,   Universitas Islam Indonesia
Published: November 2021

Ekonomi terbesar di Asia Tenggara ialah Indonesia, karena memiliki sejumlah karakteristik yang menempatkan negara di dalam posisi bagus untuk mengalami perkembangan ekonomi. Pertumbuhan yang cukup tinggi salah satunya didukung oleh sektor keuangan. Di Indonesia terdapat Indeks Harga Konsumen (IHK), perkembangan IHK dapat memperlihatkan tingkat harga suatu barang dan jasa yang dibeli masyarakat. IHK bermanfaat untuk mengetahui tingkat kenaikan pendapatan, harga, juga dapat dijadikan sebagai indikator ekonomi dan tolak ukur besarnya biaya produksi. IHK di Indonesia tidak bernilai konstan sehingga sering terjadi fluktuasi. Terjadinya fluktuasi pada IHK dapat dipengaruhi berbagai faktor. Pada penelitian ini digunakan metode regresi berganda dan cochrun orcutt untuk melihat faktor tersebut. Model yang didapatkan dari penelitian ini adalah dengan residual standard error sebesar 6.238 dan R Squared 0.192. Artinya sebesar 19.2% variabel bebas dapat menjelaskan varians dari variabel terikat. Intepretasi dari model tersebut adalah apabila Suku bunga naik satu satuan maka nilai IHK akan bertambah sebesar 11.6649 satuan.
CRISPR/Cas9-Mediated Gene-Knockout of UPF3B Alters Expression of Cell Cycle and Neuron-Specific Genes
Authors: Chandra Pratap , Deka Bhagyashree , Kumari Sweta , Rehman Ayushi , Yadav Priyanka , Singh Kusum K.
Published: November 2021

UPF3B is a constituent of the classical nonsense-mediated mRNA decay (NMD) pathway that degrades both the aberrant transcripts and a set of physiological transcripts. In higher eukaryotes, UPF3B have significant biochemical functions in diverse cellular processes including NMD and translation. UPF3B plays a crucial role in neuronal development and differentiation. Next-generation sequencing technologies identified several loss-of-function mutations in the UPF3B gene that results in neuro-developmental disorders in humans. To uncover the mechanistic role of UPF3B in neuronal functions, we have generated the UPF3B-knockout mammalian cell line model system using CRISPR-Cas9 gene editing method. RNA-Sequencing Analysis of cellular transcriptome from UPF3B-KO cells identified specific genes involved in cell growth and neuronal functions. Altered expression of genes related to the axon guidance pathway delineated the UPF3B function to regulate the neuron-specific genes. Functional enrichment analysis identified the genes involved in the disorders related to mental health and intellectual disability. Our study has the potential to identify the direct players of intellectual disability and will have broader implications.
Priority directions of increasing the adaptivity of universities to the conditions of the digital economy
Authors: Kholiavko Nataliia , Popelo Olha , Tulchynska Svitlana
Published: November 2021

The digital economy forms a set of new challenges to the higher education system, namely: accelerating the pace of socio-economic transformations; transformation of information into a commodity and a productive force; large-scale digitalization of economic entities; virtualization of workplaces; active introduction of information and communication technologies; creation of a global information field; exacerbation of cybersecurity problems. In such conditions, the system of higher education and the activities of universities need to be adequately changed in order to ensure their competitiveness in the modern market of educational services. The article substantiates the need to increase the level of adaptability of higher education institutions to exogenous challenges. Under the category of adaptability, it is proposed to understand the desired property of the higher education system, which determines its ability to absorb shocks, adapt or reorganize in accordance with the challenges posed by the development of the digital economy. The main parameters of the adaptability of the higher education system to the digital economy are the degree of its resistance to external disturbances, the depth of response to them, the speed of recovery after crises, the degree of structural and functional reorganization, the possibility of continuing pre-board development trajectory. The purpose of the article is to formulate scientifically sound proposals to increase the level of adaptability of universities to the challenges of the digital economy. The authors of the set of such proposals are structured according to the selected types of adaptability: introversion and extraversion.
An Analysis of Levels and Trends in HIV Prevalence Among Pregnant Women Attending Antenatal Clinics in Karnataka, South India, 2003-2019
Authors: Elangovan Arumugam , K David Joseph , Aridoss Santhakumar , Jaganathasamy Nagaraj , Mathiyazhakan Malathi , Ganesh Balasubramanian , Natesan Manikandan , VM Padmapriya , BK Kirubakaran , Patil Sanjay , Kumar Pradeep , Rajan Shobini
Published: November 2021

Background and Objective: Periodic tracking of the trends and the levels of HIV prevalence at regional and district levels helps to strengthen a state’s HIV/AIDS response. HIV prevalence among pregnant women is crucial for the HIV prevalence estimation of the general population. Karnataka is one of the high HIV prevalence states in India. Probing regional and district levels and trends of HIV prevalence provides critical insights into district-level epidemic patterns. This paper analyzes the region- and district-wise levels and trends of HIV prevalence among pregnant women attending the antenatal clinics (ANC) from 2003 to 2019 in Karnataka, South India.
Methods: HIV prevalence data collected from pregnant women in Karnataka during HIV Sentinel Surveillance (HSS) between 2003 and 2019 was used for trend analysis. The consistent sites were grouped into four zones (Bangalore, Belgaum, Gulbarga and Mysore regions), totaling 60 sites, including 30 urban and 30 rural sites. Regional and district-level HIV prevalence was calculated; trend analysis using Chi-square trend test and spatial analysis using QGIS software was done. For the last three HSS rounds, HIV prevalence based on sociodemographic variables was calculated to understand the factors contributing to HIV positivity in each region.
Results: In total, 254,563 pregnant women were recruited. HIV prevalence in Karnataka was 0.22 (OR: 0.15 95% CI: 0.16 - 0.28) in 2019. The prevalence was 0.24, 0.32, 0.17 and 0.14 in Bangalore, Belgaum, Gulbarga, and Mysore regions, respectively. HIV prevalence had significantly (P< 0.05) declined in 26 districts.
Conclusion and Global Health Implications: HIV prevalence among pregnant women was comparatively higher in Bangalore and Belgaum regions. Analysis of contextual factors associated with the transmission risk and evidence-based targeted interventions will strengthen HIV management in Karnataka. Regionalized, disaggregated, sub-national analyses will help identify emerging pockets of infections, concentrated epidemic zones and contextual factors driving the disease transmission.
 
Copyright © 2021. Arumugam et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License CC BY 4.0.
En torno a la ética y la trascendencia en psicoanálisis, el deseo que siempre es deseo
Authors: Coderch de Sans Joan
Published: November 2021

Relational psychoanalysis is firmly rooted in ethics, but not in ethics in its formal sense, that which we commonly call moralism, but in the response to the patient's demands and needs, an ethics that is linked to the yearning for transcendence that always nests in the human spirit and which, moreover, must always preside over patient-therapist relationships. Men and women are beings in whom desire constantly throbs, an inextinguishable desire to which they give different names and expressions, desire for pleasure in its various forms, for contact with others, for friendship, for love and also for power, for mastery of nature, of time, of space and of the course of their own existence. In this work it is emphasized that the most cursory investigation of the course of the history of humanity shows us that it is always driven by the desire for something to which it has been given different names and forms, goals, purposes and achievements, variegated and constantly contradictory to each other, but with a common denominator that, finally, links and unites them, the fact that the desire is never completely satiated, and this, in the end, pushes to a search that never rests, and in this search one reaches the most sublime of the human spirit, and also the most degrading of its nature. The different orientations of relational psychoanalysis, some of which are shown in the pages of this paper, highlight the different means by which we therapists try to help those who suffer and demand our help, and the conclusion is that most of them are entirely valid as long as they are accompanied by the love they have lacked in the early stages of their existence.
IMPROVEMENT OF THE STATE STIMULATION OF NON-COMMODITY GOODS EXPORT IN THE REPUBLIC OF BELARUS
Authors: Matviyenko E.
Published: November 2021

The article deals with main issues of foreign economic activity: the role of non-commodity
goods export in development of the national economy; state stimulation of non-commodity goods export as the most important direction of foreign economic activity of the Republic of Belarus; as well as some problems connected with the improvement of the existing export promotion mechanism and institutions in modern conditions. Possible directions of the improvement of the state stimulation of non-commodity goods export in the Republic of Belarus are proposed, according to the international experience.
Recent Increase in the Yellow-billed Magpie Population in Sacramento and Its Possible Causes
Authors: Airola Daniel A.
Published: November 2021

The Yellow-billed Magpie (Pica nuttalli) declined substantially throughout its range after the West Nile virus arrived in California in the 2000s, and neither development of disease resistance nor population recovery have been reported. After surveying 8 occupied sites in 2020 and 22 occupied sites in 2021 for a study of the magpie’s habitat use in urban Sacramento, I continued surveying 15 urban parks in 2022 and 2023 to evaluate population trends over 4 years. The Sacramento magpie population increased consistently by 3–7% per year, suggesting a localized recovery. Since the extent of foraging habitat remained stable, other factors, possibly including development of resistance to the virus (as seen in other species of birds), may be promoting a population increase. These results, however, are local and relatively short term. More work is needed to determine if resistance is developing and to understand longer-term population and disease trends in other parts of the Yellow-billed Magpie’s range.
SARS-CoV-2 air and surface contamination on a COVID-19 ward and at home
Authors: Oksanen Lotta-Maria , Virtanen Jenni , Sanmark Enni , Rantanen Noora , Venkat Vinaya , Sofieva Svetlana , Aaltonen Kirsi , Kivistö Ilkka , Svirskaite Julija , Pérez Aurora , Kuula Joel , Levanov Lev , Hyvärinen Antti-Pekka , Maunula Leena , Atanasova Nina , Laitinen Sirpa , Anttila Veli-Jukka , Lehtonen Lasse , Lappalainen Maija , Geneid Ahmed , Sironen Tarja
Published: November 2021

SARS-CoV-2 has been detected both in air and on surfaces, but questions remain about the patient-specific and environmental factors affecting virus transmission to the environment. Additionally, more detailed information on viral findings in air is needed. This cross-sectional study presents results from 259 air and 252 surface samples from the surroundings of 23 hospitalized and eight home-treated COVID-19 patients between July 2020 and March 2021 and compares the results between the measured environments and patient factors. The proportions of PCR-positive air and surface samples showed statistical similarity in hospital and in the home. In four cases, positive environmental samples were detected even after the patients had developed a neutralizing IgG response. SARS-CoV-2 RNA was detected in the following particle sizes: 0.65–4.7 μm, >7 μm, >10 μm, and <100 μm. Appropriate infection control against airborne and surface transmission routes is needed in both environments, even after antibody production has begun.
Environmental Influence on Life-History Traits in Male Squid Uroteuthis Edulis With Alternative Reproductive Tactics
Authors: Pang Yumeng , Chen Chih-Shin , Kawamura Tomohiko , Iwata Yoko
Published: November 2021

Squid are characterized by flexible life-history traits (LHTs) that change in response to changing oceanic parameters. Male alternative reproductive tactics (ARTs), characterized by large-sized ‘consorts’ versus small-sized ‘sneakers’, are commonly observed in loliginid species. This study reports on LHTs flexibility in male squids displaying ARTs. LHTs of consorts and sneakers in Uroteuthis edulis, including body size, age, growth rate and gonado-somatic energy allocation, were compared among seasonal and geographical groups from Japan and Taiwan. The ratio of consorts to sneakers was highest in the group spawning in the ‘Japan-warm’ season (June-November), followed by that of the ‘Japan-cold’ season (December-May), and lowest in Taiwan (spring and autumn). LHTs were compared among cohorts separated by hatching season and catch location (Jwarm, Jcold and Taiwan cohorts). Mean body size of consorts showed no difference among cohorts, although Taiwan consorts were relatively younger than Japan consorts. Mean size and age of sneakers decreased with increased water temperature at hatching. Growth rates of consorts and sneakers were slightly different among cohorts, in accordance with differences of statolith increment widths during their early life stage (50-150 d). Growth rates of both consorts and sneakers were highest in the Taiwan cohort, followed by the Jwarm cohort, with the Jcold cohort lowest. Sneakers invested more both in mantle and gonadal weights than consorts in all cohorts. Gonado-somatic energy allocation patterns of consorts and sneakers were consistent at different temperatures. LHTs of U. edulis consorts and sneakers were strongly influenced by temperature, with higher flexibility in sneakers than consorts.
Pediatric Malaria Incidence and Risk Mapping With and Without Clinical Data in Sussundenga Municipality, Mozambique
Authors: Ferrao Joao Luis , Mendes Robert , Tungadza Alberto , Bernardo Bernado Franque , Searle Kelly M.
Published: November 2021

BackgroundMalaria is a parasitic borne disease that affects red blood cells. The disease is preventable, detectable and treatable and more common in poor resource settings. It causes socioeconomic impacts, representing a large burden on the revenue of countries where it is endemic. Malaria is undoubtedly one of the main public health concerns impacting on families and the economy in Mozambique. Although the entire population of Mozambique is at risk of malaria, children and pregnant women have higher risk owing to lower immunity. Age category plays a significant important role in malaria occurrence and can affect the course and progression of the disease and correct treatment. Very few studies in pediatric malaria exists in Mozambique and the existing uses a simplistic and coarse grouping. Malaria risk is rarely uniform, whether considering households in a village, villages in a district or districts in a country. The knowledge of malaria pediatric incidence and, the need to evaluate the local heterogeneity by generating malaria risk maps can improve the understanding of pediatric malaria being the objective of this study. Materials and MethodsA retrospective study was conducted using existing malaria positive data from 2018 to 2019 at Rural Sussundenga Hospital (RSH) in Sussundenga municipality. Attributable factor of the disease and incidence were calculated. Proportion of gender, age category and location were tested using G test. For malaria risk mapping, ten malaria factors (anthropic, sociodemographic, climatic and clinic) were used to produce two maps one using malaria incidence and other without. Bioclimatic, Diva GIS 7.4.0 and, Landsat 8 image were used to produce the map.Results and conclusionThe findings revealed that of the, 42,248 patients who visited the local hospital f, 51.2 % tested positive for malaria with an incidence of 45.7 per 100 persons. There is a difference between residential areas in malaria incidence, with both maps showing malaria risk in Nhamazara, Nhamarenza and Unidade communities. This implies that malaria high risk areas seem to be located in high populated areas and areas close to water bodies. Relevant information is provided for effective planning in malaria intervention.
EPHB2 knockdown mitigated MI-induced myocardial injury by inhibiting MAPK signaling
Authors: Wang Hui , Gao Ying , Liu Deyun , Xiao Dong
Published: November 2021

Background
Myocardial infarction (MI) is a common disease in the cardiovascular field. The incidence of ventricular remodeling dysplasia and heart failure increases significantly after MI. The objective of this study was to investigate whether EPHB2 could regulate myocardial injury after MI and explore its regulatory pathways.
Methods
RT-qPCR and Western blot were used to verify the expression of EPHB2 in MI mice, and then shRNA knockdown of EPHB2 was used to confirm the relationship between EPHB2 expression and disease progression. The levels of inflammation, apoptosis and fibrosis were detected by tissue staining. Related factors were detected by RT-qPCR, Western blot or ELISA. Further, the signaling pathway through which EPHB affected MI processes was detected and preliminarily confirmed by Western blot.
Results
EPHB2 was significantly overexpressed in heart tissue of MI mice. Knockdown of EPHB2 gene significantly downregulated immune factors and apoptotic factors, and alleviated mi-induced cardiac tissue damage and functional decline in mice. The MAPK pathway was found to be a downstream pathway in which EPHB2 acted. Knockdown EPHB2 down-regulates phosphorylation of MAPK pathway-related proteins.
Conclusions
In mouse models, knockdown EPHB2 alleviated MI-induced cardiac function decline, inflammation and apoptosis of myocardial tissue, and myocardial fibrosis. This process may be achieved through the MAPK pathway.
Quantum Dots Based in-Vitro Co-Culture Cancer Model for Identification of Rare Cancer Cell Heterogeneity
Authors: Vyshnava Satyanarayana Swamy , Pandluru Gayathri , Kanderi Dileep Kumar , Panjala Shiva Prasad , Banapuram Swathi , Paramasivam Kameshpandian , Kothamunireddy Varalakshmi Devi , Anupalli Roja Rani , Dowlatabad Muralidhara Rao
Published: November 2021

Cancer cell heterogeneity (CCH) is a key element in understanding cancer progression and metastasis. CCH is one of the challenges in therapeutics and diagnostics stumbling block in modern medicine. An in-vitro model of co-culture systems of MCF-7, HeLa, HEK-293, with THP-1 cells showed the occurrence of CTCs like cells with EpCAM+ and other cancer cell heterogenetic types with the Quantum Dot antibody conjugates (QDAb). This in-vitro model study could provide insights into the role of rare cancer cells and heterogeneity in metastasis, as well as the severity of infections in these patients. We successfully reported the presence of CCH based on the fluorescence ratios of the co-culture cancer cells. These short-term mimic co-cultures give a compelling and quite associated model for estimating early treatment responses in various types of cancers.
Effectiveness of Intravenous Ibuprofen On Emergence Agitation in Children Undergoing Tonsillectomy With Propofol Anesthesia: A Double-Blind, Placebo-Controlled, Randomized Study
Authors: Gao Zhengzheng , Zhang Jianmin , Nie Xiaolu , Cui Xiaohuan
Published: November 2021

Background: Emergence agitation (EA) has a negative effect on recovery from general anesthesia in children. Objectives: This study aimed to evaluate the effectiveness of intravenous ibuprofen in reducing the incidence of EA in children.Methods: This randomized, double-blind, placebo-controlled study analyzed data from patients aged 3–9 years undergoing tonsillectomy with propofol general anesthesia. These patients were randomly assigned to receive either the ibuprofen or the placebo intraoperatively. The primary endpoint was between-group difference in the incidence of EA after surgery. EA was defined as Pediatric Anesthesia Emergence Delirium score ≥ 10. The secondary endpoint included the associated factors of EA.Results: Eighty-nine patients were included in the study. Ibuprofen decreased the incidence of EA (8.9% in the treatment group vs. 34.1% in the control group; odds ratio [OR], 0.261; 95% confidence interval [CI], 0.094–0.724; P = 0.004). After the logistic regression analysis, anxiety behavior pre-anesthesia and high pain score after surgery were the risk factors related to EA (OR, 8.07; 95% CI, 1.12–58.07, P = 0.038 and OR, 2.78; 95% CI, 1.60–4.82, P < 0.001, respectively). Ibuprofen administration was the protective factor related to EA (OR, 0.05; 95% CI, 0.01–0.67, P = 0.023).Conclusions: In our studied cohort, intraoperatively infusing ibuprofen and relieving preoperative anxiety and postoperative pain can significantly reduce the incidence and severity of EA after propofol general anesthesia.Trial registration: ChiCTR2100045128 (07/04/2021)
The Prognostic Value of Peripheral Inflammatory Cell Ratios in Patients with Cervical Cancer After Radiotherapy
Authors: Xu Ruizhe , Lu Haiyan , Guo Qi , Qian Jianjun , Fan Qiuhong , Zhao Peifeng , Tian Ye
Published: November 2021

Introduction: This study aimed to explore the values of the neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) as prognostic biomarkers in patients with cervical cancer.Methods: In total, 172 cervical cancer patients treated with radiotherapy between January 2014 and December 2017 were retrospectively identified. We calculated the NLR and PLR and determined their cut-off points, known prognostic factors, and the association of these factors with overall survival (OS).Results: The median follow-up period was 59 months (range 1–91 months, 95% confidence interval 53–63 months). The 3- and 5-year OS rates of patients who received postoperative adjuvant radiotherapy were 86.7% and 79.7%, respectively, while the 3- and 5-year OS rates of patients who received radical radiotherapy were 70.2% and 61.6%, respectively. Univariate analysis identified that OS was significantly correlated with tumor diameter, pelvic lymph node status, the NLR and PLR before radiotherapy, past diabetes, International Federation of Gynecology and Obstetrics (FIGO) stage, the purpose of radiotherapy, pathology type, and the OS rate (all P<0.05). On multivariate analysis, the PLR before radiotherapy, past diabetes, FIGO stage, and pathology type were independently associated with OS (all P<0.05). Conclusions: The NLR and PLR before radiotherapy are correlated with the prognosis of cervical cancer. Furthermore, the PLR before radiotherapy is an independent risk factor related to OS.
Impact Analysis of the Interobserver Variability in CBCT-Based Soft-Tissue Matching using TCP/NTCP Models for Prostate Cancer Radiotherapy
Authors: Zhang Xiangbin , Wang Xin , Li Xiaoyu , Zhou Li , Nie Shihong , Li Changhu , Wang Xuetao , Dai Guyu , Deng Zhonghua , Zhong Renming
Published: November 2021

Background: Prostate alignment is subject to interobserver variability in cone-beam CT (CBCT)-based soft-tissue matching. This study aims to analyze the impact of interobserver variability in CBCT-based soft-tissue matching for prostate cancer radiotherapy.Methods: Retrospective data, consisting of 156 CBCT images from twelve patients with intermediate- or high-risk prostate cancer were analyzed in this study. To simulate interobserver variability, couch shifts of 2 mm relative to the resulting patient position of prostate alignment were assumed as potential patient positions (27 possibilities). For each CBCT, the doses of the potential patient positions were recalculated using deformable image registration-based synthetic CT. The impact of the simulated interobserver variability was evaluated using tumor control probabilities (TCPs) and normal tissue complication probabilities (NTCPs).Results: No significant differences in TCPs were found between prostate alignment and potential patient positions (0.944 ± 0.003 vs 0.945 ± 0.003, P = 0.117). The average NTCPs of the rectum ranged from 5.16 (%) to 7.29 (%) among the potential patient positions and were highly influenced by the couch shift in anterior-posterior direction. In contrast, the average NTCPs of the bladder ranged from 0.75 (%) to 1.12 (%) among the potential patient positions and were relatively negligible.Conclusions: The NTCPs of the rectum, rather than the TCPs of the target, were highly influenced by the interobserver variability in CBCT-based soft-tissue matching. This study provides a theoretical explanation for daily CBCT-based image guidance and the prostate-rectum interface matching procedure.Trial registration: Not applicable.
Prediction of Uric Acid Component in Nephrolithiasis Using Simple Clinical Information: A Machine Learning-Based model
Authors: Chen Hao-Wei , Chen Yu-Chen , Lee Jung-Ting , Kao Chung-Yao , Chou Yii-Her , Chu Ting-Yin , Juan Yung-Shun , Wu Wen-Jeng
Published: November 2021

There is a great need for a diagnostic tool using simple clinical information collected from patients to diagnose uric acid (UA) stones in nephrolithiasis. We built a predictive model making use of machine learning (ML) methodologies entering simple parameters easily obtained at the initial clinical visit. Socio-demographic, health, and clinical data from two cohorts (A and B), both diagnosed with nephrolithiasis, one between 2012 and 2016 and the other between June and December 2020, were collected before nephrolithiasis treatment. A ML-based model for predicting UA stones in nephrolithiasis was developed using eight simple parameters - sex, age, gout, diabetes mellitus, body mass index, estimated glomerular filtration rate, bacteriuria, and urine pH. Data from Cohort A were used for model training and validation (ratio 3:2), while data from Cohort B were used only for validation. One hundred forty-six (13.3%) of 1098 patients Cohort A and three (4.23%) of 71 patients in Cohort B had pure UA stones. For Cohort A, our model achieved validation AUC (area under ROC curve) of 0.842, with 0.8475 sensitivity and 0.748 specificity. For Cohort B, our model achieved 0.936 AUC, with 1.0 sensitivity, and 0.912 specificity. This ML-based model provides a convenient and reliable method for diagnosing urolithiasis. Using only eight readily available clinical parameters, it distinguished pure uric acid stones from other stones before treatment.
Aberrant Expression of The Esophageal Carcinoma Related Gene 4 As A Prognostic Signature For Hepatocellular Carcinoma
Authors: You Yanjie , Hu Shengjuan , Deng Yanghong , Hu Fangrui
Published: November 2021

Background. Hepatocellular carcinoma (HCC) is a lethal cancer with increasing incidence, yet the molecular biomarkers that have strong prognostic impact and also hold great therapeutic promise remain elusive. Methods. Data mining approaches with a set of publicly accessible databases and immunohistochemistry were used to provide a novel insight into the expression pattern and prognostic significance of the esophageal cancer-related gene (ECRG) family members in HCC. Results. We found that elevated mRNA expression levels of ECRG factors were correlated with better overall survival, relapse-free survival and progression-free survival rates in patients with HCC. Subgroup analyses showed significant associations between ECRG expression and survival outcome in select HCC patients. In addition, immunohistochemical and multivariate analysis confirmed increased ECRG4 expression as an independent prognostic indicator for survival. Conclusion. Our data suggest that ECRG factors have significant impacts on the survival of HCC patients. The expression of ECRG factors may be involved in HCC progression and could serve as novel biomarkers for predicting more accurate prognosis.
Work Stress in Nurses Returning To Tertiary A General Hospitals in China After The Delivery of Their Second Child: A Cross-Sectional Study
Authors: Chen Kai , Wei Lili , Zhang Yan , Jiang Wenbin , Wang Jingyuan , Pan Yueshuai
Published: November 2021

Objective To investigate the current situation of work stress in nurses returning to work in Chinese tertiary A general hospitals after giving birth to their second child and to analyze influencing factors. Methods From January to April 2021, 448 nurses returning to work after the birth of their second child, working in 23 general hospitals in China, were investigated and completed the postpartum work stress scale and self-rating depression scale. Results The total work stress score of returning nurses after giving birth to their second child was 90.40±18.29, and the dimension with the highest score was the role commitment of the mother. Multiple linear regression analysis showed that family monthly income, turnover intention, time since returning to work, age of the first child, and depression were the influencing factors on job stress. Conclusion The work stress of nurses returning to work in China’s tertiary A general hospitals after the birth of their second child is in the upper-middle range. Nursing managers should pay attention to this group of postpartum nurses and formulate targeted measures to reduce their work stress.