bluuebunny/crossref_metadata_2025 huggingface dataset:
Water in clinopyroxene from the 2021 Geldingadalir eruption of the Fagradalsfjall Fires, SW-Iceland
Authors: Radu Ioana-Bogdana , Skogby Henrik , Troll Valentin R. , Deegan Frances M. , Geiger Harri , Müller Daniel , Thordarson Thor
Published: April 2023

Water content plays a significant role in magma genesis, ascent rate, and, ultimately, in the style and intensity of volcanic eruptions, due to its control on the density, viscosity and melting behaviour of silicate melts. A reliable method for determining the pre-eruptive magmatic water content is to use phenocrysts of nominally anhydrous minerals (NAMs) which can preserve water as hydrogen configurations in structural defects. The advantage of this method is that eruptive changes such as water loss during magma degassing may be experimentally reconstructed and analysed by infrared spectroscopy. Applying this to clinopyroxene crystals (n=17) from lava samples (n=7) from April 2021 of the Geldingadalir eruption, SW-Iceland, reveals parental water contents of 0.69 ± 0.07 to 0.86 ± 0.09 wt. % H2O. These values are higher than those expected for typical mid-ocean ridge basalts (MORB 0.3–0.5 wt. % on average) indicating a significant plume (OIB) contribution to the magma source. Moreover, such water concentrations would imply that water saturation in the ascending Geldingadalir magmas was attained only at very shallow levels within the plumbing system. This could explain the at times pulsating behaviour within the uppermost conduit system as being the result of shallow episodic water vapour exsolution in addition to the deep-sourced CO2flux.
Physics-informed machine-learning model of temperature evolution under solid phase processes
Authors: King Ethan , Li Yulan , Hu Shenyang , Machorro Eric
Published: April 2023

We model temperature dynamics during Shear Assisted Proccess Extrusion (ShAPE), a solid phase process that plasticizes feedstock with a rotating tool and subsequently extrudes it into a consolidated tube, rod, or wire. Control of temperature is critical during ShAPE processing to avoid liquefaction, ensure smooth extrusion, and develop desired material properties in the extruded products. Accurate modeling of the complicated thermo-mechanical feedbacks between process inputs, material temperature, and heat generation presents a significant barrier to predictive modeling and process design. In particular, connecting micro-structural scale mechanisms of heat generation to macro-scale predictions of temperature can become computationally intractable. In this work we use a neural network (NN) model of heat generation to bridge this gap, by combining it with a simplified model of the temperature dynamics due to conduction and convection to capture the macro scale evolution of temperature. We inform the construction of the NN heat generation model using crystal plasticity simulations at the micro-structural scale to model the effects of process inputs on generation of heat. We achieved close fits of the temperature dynamics model to a diverse experimental data-set. Further, the relationships learned by the NN model between process inputs and heat generation showed qualitative agreement with those predicted by crystal plasticity simulations.
Backward-Eulerian Footprint Modelling Based on the Adjoint Equation for Atmospheric and Urban-Terrain Dispersion
Authors: Jia Hongyuan , Kikumoto Hideki
Published: April 2023

This study developed a backward-Eulerian footprint modelling method based on an adjoint equation for atmospheric boundary-layer flows. In the proposed method, the concentration footprint can be obtained directly by numerical simulation with the adjoint equation, and the flux footprints can be estimated using the adjoint concentration based on the gradient diffusion hypothesis. We first tested the proposed method by estimating the footprints for an ideal three-dimensional boundary layer with different atmospheric stability conditions based on the Monin–Obukhov profiles. It was indicated that the results were similar to the FFP method (Kljun et al. in Boundary-Layer Meteorol 112:503–523, 2004, https://doi.org/10.1023/B:BOUN.0000030653.71031.96; Geosci Model Dev 8:3695–3713, 2015, https://doi.org/10.5194/gmd-8-3695-2015) for convective conditions and the K–M method (Kormann and Meixner in Boundary-Layer Meteorol 99:207–224, 2001, https://doi.org/10.1023/A:1018991015119) for stable conditions. The proposed method was then coupled with the Reynolds averaged Navier–Stokes model to calculate the footprints for a block-arrayed urban canopy. The results were qualitatively compared to the results from the Lagrangian-Large-Eddy-Simulation (LL) method (Hellsten et al. in Boundary-Layer Meteorol 157:191–217, 2015, https://doi.org/10.1007/s10546-015-0062-4). It was shown that the proposed method reproduced the main features of footprints for different sensor positions and measurement heights. However, it is necessary to simulate the adjoint equation with a more sophisticated turbulence model in the future to better capture turbulent effects in the footprint modelling.
Smallholder oil palm plantation sustainability assessment using multi-criteria analysis and unmanned aerial vehicles
Authors: Wong Yong Bin , Gibbins Chris , Azhar Badrul , Phan Su Shen , Scholefield Paul , Azmi Reza , Lechner Alex M.
Published: April 2023

Oil palm agriculture has caused extensive land cover and land use changes that have adversely affected tropical landscapes and ecosystems. However, monitoring and assessment of oil palm plantation areas to support sustainable management is costly and labour-intensive. This study used an unmanned aerial vehicles (UAV) to map smallholder farms and applied multi-criteria analysis to data generated from orthomosaics, to provide a set of sustainability indicators for the farms. Images were acquired from a UAV, with structure from motion (SfM) photogrammetry then used to produce orthomosaics and digital elevation models of the farm areas. Some of the inherent problems using high spatial resolution imagery for land cover classification were overcome by using texture analysis and geographic object-based image analysis (OBIA). Six spatially explicit environmental metrics were developed using multi-criteria analysis and used to generate sustainability indicator layers from the UAV data. The SfM and OBIA approach provided an accurate, high-resolution (~5 cm) image-based reconstruction of smallholder farm landscapes, with an overall classification accuracy of 89%. The multi-criteria analysis highlighted areas with lower sustainability values, which should be considered targets for adoption of sustainable management practices. The results of this work suggest that UAVs are a cost-effective tool for sustainability assessments of oil palm plantations, but there remains the need to plan surveys and image processing workflows carefully. Future work can build on our proposed approach, including the use of additional and/or alternative indicators developed through consultation with the oil palm industry stakeholders, to support certification schemes such as the Roundtable on Sustainable Palm Oil (RSPO).
Correct Use of the Transient Hot-Wire Technique for Thermal Conductivity Measurements on Fluids
Authors: Assael Marc J. , Antoniadis Konstantinos D. , Velliadou Danai , Wakeham William A.
Published: April 2023

The paper summarizes the conditions that are necessary to secure accurate measurements of the thermal conductivity of fluids using the transient hot-wire technique. The paper draws upon the development of the method over five decades to produce a prescription for its use. The purpose is to provide guidance on the implementation of the method to those who wish to make use of it for the first time. It is shown that instruments of the transient hot-wire type can produce measurements of the thermal conductivity with the smallest uncertainty yet achieved (± 0.2%). This can be achieved either when a finite element method (FEM) is employed to solve the relevant heat transfer equations for the instrument or when an approximate analytic solution is used to describe it over a limited range of experimental times from 0.1 s to 1 s. As well as establishing the constraints for the proper operation of the instrument we consider the means that should be employed to demonstrate that the experiment operates in accordance with the theoretical model of it. If the constraints are all satisfied then an uncertainty in thermal conductivity measurements of as little as ± 0.2–0.5% can be obtained for gases and liquids over a wide range of thermodynamic state from 0.1 MPa to 700 MPa and temperatures from 70  K to 500 K with the exception of near critical conditions. It is observed that many applications of the transient hot-wire technique do not conform to the constraints set out here and therefore may be burdened with very much greater uncertainties, sometimes large enough to render the results meaningless.
Surface modification of stereolithography-based 3D printed structures utilizing ultrasonic-atomised sprays
Authors: Kanjirakat Anoop , Carvero Arnel , Amani Mahmood , Retnanto Albertus
Published: April 2023

Stereolithography (SLA)-based three-dimensional (3D) printing has become a popular tool for creating experimental models to study the two-phase flow behavior in complex flow structures. The main drawback while implementing such models is the wettability nature of the 3D printed surfaces. As non-geological materials are used while printing the porous designs, the flow mechanics do not follow similar patterns as in the reservoir. This work demonstrates the feasibility of using an SLA-based printing technique to replicate a porous structure. The porosity and pore size values of the 3D print are observed to be very close to that of the porous input image of the rock sample. A simple method to modify the surface characteristics of 3D printed surfaces using an ultrasonic-atomized fine spraying technique is developed. Here a thin layer of CaCO3 is deposited on the 3D printed surface by subjecting it to fine alternate sprays of calcium chloride and sodium carbonate. Thirty cycles of coating are observed to have altered the surface's wettability from neutral to oil-wet, resembling a carbonate reservoir.

Graphical abstract

Ultrasonic assisted coating of 3D-printed surfaces.
The effect of contrasting biosolids application strategies on soil quality
Authors: Gutiérrez-Ginés M. J. , Lehto N. J. , Madejón E. , Robinson B. H.
Published: April 2023

Purpose

Incorporating biosolids into the soil improves plant yield compared with surface application, but it can result in the increased uptake of trace elements. However, there is a lack of knowledge about how different types of biosolids applications affect soil quality. We aimed to determine the effect of the type and rate of biosolids application on soil quality and the mobility of contaminants.

Methods

Soil quality was determined by soil fertility (inorganic N, exchangeable P, Mg, Ca, K), exchangeable trace and non-essential elements (Al, Mn, Zn, Cu and Cd) and biological activity (dehydrogenase activity). We measured the properties of soil pore water, bulk soil and rhizosphere in a pot and a rhizobox experiment, with increasing concentration of biosolids (equiv. 16 t ha− 1, 48 t ha− 1 and 145 t ha− 1 dry weight), applied on the surface, incorporated to 25 cm, or incorporated into a patch.

Results and discussion

The incorporation of biosolids into the soil increased the exchangeable Zn, Cu, Cr, Ni and Cd, compared with surface application. The surface application of biosolids increased the inorganic N in the soil compared with biosolids incorporation (680 mg kg− 1 vs. 380 mg kg− 1), and decreased soil pH by 1.1 units. This aligned with solubilisation of Al (43 mg kg− 1 vs. 6 mg kg− 1) and Mn (43 mg kg− 1 vs. 33 mg kg− 1) and explains the decreased microbial activity in the soil compared with the unamended soil. Incorporating biosolids in the soil increased the biological activity, likely due to biosolids-borne microbes. The root systems significantly increased microbial activity, pH, and the concentration of NH4+, NO3−, and exchangeable P, S, Mg, Na, Zn, Cu and Ni, and significantly decreased exchangeable concentration of Mn and Fe.
Photosynthesis and food security: the evolving story of C4 rice
Authors: Furbank Robert , Kelly Steven , von Caemmerer Susanne
Published: April 2023

Traditional “Green Revolution” cereal breeding strategies to improve yield are now reaching a plateau in our principal global food crop rice. Photosynthesis has now become a major target of international consortia to increase yield potential. Synthetic biology is being used across multiple large projects to improve photosynthetic efficiency. This review follows the genesis and progress of one of the first of these consortia projects, now in its 13th year; the Bill and Melinda Gates funded C4 Rice Project. This project seeks to install the biochemical and anatomical attributes necessary to support C4 photosynthesis in the C3 crop rice. Here we address the advances made thus far in installing the biochemical pathway and some of the key targets yet to be reached.
The emergence of social soft skill needs in the post COVID-19 era
Authors: Gnecco Giorgio , Landi Sara , Riccaboni Massimo
Published: April 2023

Social soft skills are crucial for workers to perform their tasks, yet it is hard to train people on them and to readapt their skill set when needed. In the present work, we analyze the possible effects of the COVID-19 pandemic on social soft skills in the context of Italian occupations related to 88 economic sectors and 14 age groups. We leverage detailed information coming from ICP (i.e. the Italian equivalent of O*Net), provided by the Italian National Institute for the Analysis of Public Policy, from the microdata for research on the continuous detection of labor force, provided by the Italian National Institute of Statistics (ISTAT), and from ISTAT data on the Italian population. Based on these data, we simulate the impact of COVID-19 on workplace characteristics and working styles that were more severely affected by the lockdown measures and the sanitary dispositions during the pandemic (e.g. physical proximity, face-to-face discussions, working remotely). We then apply matrix completion—a machine-learning technique often used in the context of recommender systems—to predict the average variation in the social soft skills importance levels required for each occupation when working conditions change, as some changes might be persistent in the near future. Professions, sectors, and age groups showing negative average variations are exposed to a deficit in their social soft-skills endowment, which might ultimately lead to lower productivity.
Health utilities and willingness to pay in adult patients with coeliac disease in Hungary
Authors: Angyal M. Mercédesz , Lakatos Peter L. , Jenei Balázs , Brodszky Valentin , Rencz Fanni
Published: April 2023

Background

Coeliac disease (CD) is a life-long food-related disorder with a global prevalence of approximately 1%. Patients with CD often experience reduced health-related quality of life that could improve with a strict adherence to a gluten-free diet (GFD).

Objectives

To obtain visual analogue scale (VAS), time trade-off (TTO) and willingness-to-pay (WTP) values amongst patients with CD.

Methods

In 2020–2021, a cross-sectional online survey was conducted amongst 312 adult CD patients in Hungary. Patients completed the Gastrointestinal Symptom Rating Scale (GSRS) and evaluated their current health and three hypothetical health state vignettes defined based on dietary adherence using VAS, conventional 10-year TTO and WTP. Multivariate regressions were used to explore the effect of patients’ demographic and clinical characteristics on utility and WTP values.

Results

Mean VAS values for current health and ‘CD with strict adherence to GFD’, ‘CD with loose adherence to GFD’ and ‘CD without GFD’ hypothetical health states were 79.69 ± 18.52, 85.36 ± 16.18, 62.44 ± 19.91 and 36.69 ± 25.83, respectively. Corresponding mean TTO utilities were: 0.90 ± 0.19, 0.91 ± 0.20, 0.87 ± 0.23 and 0.76 ± 0.29. Mean annual WTP values for returning to full health were: €845 ± 1077, €648 ± 1002, €862 ± 1135 and €1251 ± 1496. Older age at diagnosis, male sex, more severe gastrointestinal symptoms (GSRS) and having comorbidities were associated with lower VAS and TTO or higher WTP values for current own health (p < 0.05).

Conclusion

This is the first study to report TTO utilities for CD health states. Strict adherence to the GFD may result in substantial health gains in symptomatic patients. Utilities and WTP results can be used to estimate benefits of GFD in cost-utility and cost–benefit analyses.
A robust walking detection algorithm using a single foot-worn inertial sensor: validation in real-life settings
Authors: Prigent Gaëlle , Aminian Kamiar , Cereatti Andrea , Salis Francesca , Bonci Tecla , Scott Kirsty , Mazzà Claudia , Alcock Lisa , Del Din Silvia , Gazit Eran , Hansen Clint , Paraschiv-Ionescu Anisoara ,   for the Mobilise-D consortium
Published: April 2023

Walking activity and gait parameters are considered among the most relevant mobility-related parameters. Currently, gait assessments have been mainly analyzed in laboratory or hospital settings, which only partially reflect usual performance (i.e., real world behavior). In this study, we aim to validate a robust walking detection algorithm using a single foot-worn inertial measurement unit (IMU) in real-life settings. We used a challenging dataset including 18 individuals performing free-living activities. A multi-sensor wearable system including pressure insoles, multiple IMUs, and infrared distance sensors (INDIP) was used as reference. Accurate walking detection was obtained, with sensitivity and specificity of 98 and 91% respectively. As robust walking detection is needed for ambulatory monitoring to complete the processing pipeline from raw recorded data to walking/mobility outcomes, a validated algorithm would pave the way for assessing patient performance and gait quality in real-world conditions.

Graphical Abstract
Thermally induced solid-state reaction of Fe2(SO4)3 with NaCl or KCl: a route to β-Fe2O3 synthesis
Authors: Kopp Josef , Kalusová Karolína , Procházka Vít , Novák Petr
Published: April 2023

β-Fe2O3 is a rare crystalline polymorph of the ferric oxide family with an interesting application potential, e.g., in photocatalysis. In this study, the effect of different alkali salts addition, namely NaCl and KCl, on the preparation of β-Fe2O3 via thermally induced solid-state reaction was investigated. Two series of samples were prepared by calcining two different mixtures, Fe2(SO4)3 + NaCl (molar ratio 1:3) and Fe2(SO4)3 + KCl (molar ratio 1:3) at temperatures from 350 to 700 °C. Although the addition of either alkali salt led the preparation of β-Fe2O3 particles in wide temperature range up to 650 °C, differences in the overall phase composition and β-Fe2O3 purity were observed between the two series. The addition of KCl to Fe2(SO4)3 allowed the preparation of pure β-Fe2O3 (≥ 95%) in relatively wide temperature range of 450‒600 °C, while in the case of NaCl, pure β-Fe2O3 (≥ 95%) was found only in samples calcined at 500 °C and 550 °C. Other phases could be identified as additional ferric oxide polymorphs, γ-Fe2O3 and α-Fe2O3. The in situ XRD results suggest that, in the case of NaCl + Fe2(SO4)3 reaction, simultaneous formation of β-Fe2O3 and α-Fe2O3 may be possible between 350 and 500 °C, depending on the reaction conditions.
Metabolic adverse events of multitarget kinase inhibitors: a systematic review
Authors: Acitelli Elisa , Maiorca Carlo , Grani Giorgio , Maranghi Marianna
Published: April 2023

Purpose

Multitargeted kinase inhibitors (MKIs) are used for the treatment of several cancers. By targeting multiple signaling pathways, MKIs have become cornerstones of the oncologic treatment. Although their use leads to important results in terms of survival, treatment with MKIs can determine important side effects the clinician must be aware of. Among those, arterial hypertension, mucositis and skin lesions are universally reported, while data about metabolic alterations are scarce. In our review, we focused on glucose and lipid alterations in MKI-treated patients.

Methods

We searched for articles, published between January 2012 and December 2022, evaluating the effects on lipid and glucose metabolism of four MKIs (Cabozantinib, Lenvatinib, Sorafenib, and Vandetanib) in adult patients with cancer. We focused on drugs approved for thyroid malignancies, since a worse metabolic control may potentially impact life expectancy, due to their better overall survival rate.

Results

As for glucose metabolism, the majority of the studies reported elevation of glucose levels (prevalence: 1–17%) with different grades of severity, including death. As for cholesterol, 12 studies reported worsening or new-onset hypercholesterolemia (prevalence: 4–40%). Finally, 19 studies reported different grades of hypertriglyceridemia (prevalence: 1–86%), sometimes leading to life-threatening events.

Conclusions

Despite some inherent limitations, our analysis may cast light upon some of the MKIs metabolic disorders that can impact on patients’ health, especially when long-term survival is expected. Future clinical trials should consider routine assessment of glucose and lipid levels, because underdetection and underreporting of alterations can lead to the overlooking of important adverse events.
Bone finds and their medicolegal examination: a study from Hesse, Germany
Authors: Ohlwärther T. E. N. , Holz F. , Edler K. , Kölzer S. C. , Reuss E. , Verhoff M. A. , Birngruber C. G.
Published: April 2023

Bones found by chance can be of great criminal or historical interest. The nature of their appraisal depends on the individual case, the locally effective legislation and the available resources. To assess whether a find is relevant with respect to criminal investigation, the circumstances of the find and the results of the forensic examination carried out by trained personnel must be considered. The aim of this study was to obtain an overview of the circumstances and nature of the finds as well as the results of the subsequent expert opinions by evaluating bone finds from the federal state of Hesse, Germany. For this purpose, over a 10-year period from 2011 to 2020, all bone finds examined at the Institutes of Legal Medicine in Gießen and Frankfurt am Main, Germany, were evaluated retrospectively with regard to the locations and circumstances of the finds, their nature (human or non-human), the postmortem interval, possible traces of violent impact and the results of further examinations. Of the 288 bone finds evaluated, 38.2% were found in forests, meadows and parks. In 50.7%, the finds contained human bones, of which 37.0% had a forensically relevant postmortem interval of 50 years or less. Evidence of trauma was described in 77.4% of the human bone cases: postmortem damage in 78.8%, peri-mortem injury in 9.7% and ante-mortem injury in 11.5%. DNA examinations were performed in 40.4% of the human bone finds. They yielded STR profiles in 81.3%, leading to a definite identification in 35.4%. Among the non-human bones sent in, the most common were bones from pigs (23.4%), deer (18.1%), cattle (16.4%), roe deer (11.7%) and sheep (11.7%). The macroscopic examination is the first step of the forensic-osteological evaluation and sets the course for further examinations or investigations. DNA examinations are of great importance for the reliable identification of human bones. They were responsible for 70.8% of successful identifications.
Landscape of NcRNAs involved in drug resistance of breast cancer
Authors: Kang Yujuan
Published: April 2023

Breast cancer (BC) leads to the most amounts of deaths among women. Chemo-, endocrine-, and targeted therapies are the mainstay drug treatments for BC in the clinic. However, drug resistance is a major obstacle for BC patients, and it leads to poor prognosis. Accumulating evidences suggested that noncoding RNAs (ncRNAs) are intricately linked to a wide range of pathological processes, including drug resistance. Till date, the correlation between drug resistance and ncRNAs is not completely understood in BC. Herein, we comprehensively summarized a dysregulated ncRNAs landscape that promotes or inhibits drug resistance in chemo-, endocrine-, and targeted BC therapies. Our review will pave way for the effective management of drug resistance by targeting oncogenic ncRNAs, which, in turn will promote drug sensitivity of BC in the future.
Venous thromboembolism in Japanese patients with breast cancer: subgroup analysis of the Cancer-VTE Registry
Authors: Ohsumi Shozo , Watanabe Kenichi , Kondo Naoto , Kosaka Yoshimasa , Ishikawa Takashi , Kitahara Miyuki , Kubo Shinichiro , Oba Mari S. , Kimura Tetsuya , Takita Atsushi , Mukai Hirofumi
Published: April 2023

Background

This subgroup analysis of the Cancer-VTE Registry, a nationwide, large-scale, multicenter observational study with a 1-year follow-up, assessed real-world data on venous thromboembolism (VTE) among Japanese patients with breast cancer.

Methods

Patients with stage II–IV pretreatment breast cancer screened for VTE at enrollment were included. During the 1-year follow-up period, incidences of VTE, bleeding, and all-cause death, and background factors associated with VTE risk were examined.

Results

Of 9,630 patients in the Cancer-VTE Registry analysis set, 993 (10.3%) had breast cancer (973 [98.0%] did not have and 20 [2.0%] had VTE at baseline). The mean age was 58.4 years, 73.4% of patients had stage II cancer, and 94.8% had an Eastern Cooperative Oncology Group performance status (ECOG PS) of 0. Risk factors for VTE at baseline by univariable analysis were age ≥ 65 years, ECOG PS of 2, VTE history, and D-dimer > 1.2 μg/mL. During follow-up, the incidence of symptomatic VTE was 0.4%; incidental VTE requiring treatment, 0.1%; composite VTE (symptomatic VTE and incidental VTE requiring treatment), 0.5%; bleeding, 0.2%; cerebral infarction/transient ischemic attack/systemic embolic event, 0.2%; and all-cause death, 2.1%. One patient with symptomatic VTE developed pulmonary embolism (PE) and died. Incidences of VTE and all-cause death were higher in patients with VTE vs without VTE at baseline.

Conclusions

In Japanese patients with breast cancer, VTE screening before initiating cancer treatment revealed a 2.0% prevalence of VTE. During follow-up, one patient had a fatal outcome due to PE, but the incidences of VTE were low.

Clinical trial registration

UMIN000024942; UMIN Clinical Trials Registry: https://www.umin.ac.jp/ctr/.
Superstructure optimization of subsea processing layouts
Authors: Sales Leonardo , Stanko Milan , Jäschke Johannes
Published: April 2023

As the oil and gas industry expands the use of subsea processing, the complexity of subsea layouts increases, making manual design processes cumbersome and suboptimal. Here we propose a method to support subsea field design where optimization is performed on a model of the subsea system, to maximize the net present value of the project. The proposed mixed-integer nonlinear (MINLP) model is solved to compute a global optimum design considering constraints in production, equipment duties and cost, and reliability and maintenance aspects. The subsea layout, equipment capacity, oil and gas production rates, and system pressures are optimized. The method was applied on a synthetic field based on the Goliat field in the Barents Sea. The method successfully finds the best designs, while the second and third-best layouts give general insights for subsea processing layout optimization.
Detoxification strategy of wheat straw hemicellulosic hydrolysate for cultivating Trichoderma reesei: a contribution towards the wheat straw biorefinery
Authors: Daza-Serna L. , Masi A. , Serna-Loaiza S. , Pfnier J. , Stark G. , Mach R. L. , Mach-Aigner A.R. , Friedl A.
Published: April 2023

The urgency for reducing the dependence on fossil-based materials is increasing the interest in the utilization of renewable feedstocks. Lignocellulosic residual biomass can be used as feedstock to produce chemicals and energy without generating food security problems. Wheat straw (WS) has a clear potential for developing sustainable processes in a circular bioeconomy context. However, the development of processes requires a strategy for utilizing the hemicellulosic, cellulosic, and lignin fractions. This work covers the utilization of the hemicellulosic fraction as the first stage of a wheat straw biorefinery. The aim was to evaluate the hydrolysis of WS by using liquid hot water (LHW) treatment, the detoxification of the produced wheat straw hydrolysate (WSH), and the cultivation of Trichoderma reesei using it as the only carbon source as proof of detoxification. LHW treatment was performed at 160 °C and 90 min and yielded a WSH rich in monomeric and oligomeric saccharides (~ 14 g/L) and containing degradation products in low concentration (furfural, HMF, and acetic acid). As part of the development of the extraction and detoxification strategy, we determined the specific inhibition thresholds for T. reesei for the mentioned degradation products. Detoxification was carried out by evaporation by modifying the % of volume evaporated and the pH of the solution. Approximately 55.9% of acetic acid and 100% of furfural were removed from the WSH. The fungal biomass obtained in the medium containing WSH was equivalent to 98% of the biomass obtained in the control medium.
A new Bihari inequality and initial value problems of first order fractional differential equations
Authors: Lan Kunquan , Webb J. R. L.
Published: April 2023

We prove existence of solutions, and particularly positive solutions, of initial value problems (IVPs) for nonlinear fractional differential equations involving the Caputo differential operator of order $$\alpha \in (0,1)$$

α
∈
(
0
,
1
)

. One novelty in this paper is that it is not assumed that f is continuous but that it satisfies an $$L^{p}$$

L
p

-Carathéodory condition for some $$p>\frac{1}{\alpha }$$

p
>

1
α

(detailed definitions are given in the paper). We prove existence on an interval [0, T] in cases where T can be arbitrarily large, called global solutions. The necessary a priori bounds are found using a new version of the Bihari inequality that we prove here. We show that global solutions exist when f(t, u) grows at most linearly in u, and also in some cases when the growth is faster than linear. We give examples of the new results for some fractional differential equations with nonlinearities related to some that occur in combustion theory. We also discuss in detail the often used alternative definition of Caputo fractional derivative and we show that it has severe disadvantages which restricts its use. In particular we prove that there is a necessary condition in order that solutions of the IVP can exist with this definition, which has often been overlooked in the literature.
A Critical Review on Glass Fiber-Reinforced Polymer Bars as Reinforcement in Flexural Members
Authors: Kinjawadekar Trupti Amit , Patil Shantharam , Nayak Gopinatha
Published: April 2023

Since the nineteenth century, reinforced concrete was evolved as a crucial material for construction. This popular composite material is broadly used in different building typologies. However, the decaying of steel rebar due to corrosion is identified as a hindrance that can affect the quality of reinforced concrete structures. In reference to this, the glass fiber-reinforced polymer (GFRP) bar is essential because of corrosion-resistant properties. The researchers performed various tests and numerical analysis to know the response of GFRP-reinforced flexural members in shear and bending. Based on studies over the last decade, this study critically analyzes the response of flexural member reinforced using glass fiber-reinforced polymer (FRP) bars. Understanding the behavior of the FRP bar as the alternating reinforcing material will be aided by this review. Since the GFRP bar has high strength and no yield point, the conventional characterizations of ductility may not be applicable to determine whether GFRP-reinforced concrete components are ductile. Hence, a detailed study is needed to understand the behavior of such structures. This paper explores various properties of GFRP-reinforced beams to appreciate the applications of GFRP reinforcement in flexural members.
Multi-source statistics on employment status in Italy, a machine learning approach
Authors: Varriale Roberta , Alfo’ Marco
Published: April 2023

In recent decades, National Statistical Institutes have started to produce official statistics by exploiting multiple sources of information (multi-source statistics) rather than a single source, usually a statistical survey. In this context, one of the research projects addressed by the Italian National Statistical Institute (Istat) concerned methods for producing estimates on employment in Italy using survey data and administrative sources. The former are drawn from the Labour Force survey conducted by Istat, the latter from several administrative sources that Istat regularly acquires from external bodies. We use machine learning methods to predict the individual employment status. This approach is based on the application of decision tree and random forest techniques, that are frequently used to classify large amounts of data. We show how to construct a “new” response variable denoting agreement of the data sources: this approach is shown to maximise the information we may derive by machine learning approach in some problematic cases. The methods have been applied using the R software.
Transition to retirement impact on smoking habit: results from a longitudinal analysis within the Survey of Health, Ageing and Retirement in Europe (SHARE) project
Authors: Bertuccio Paola , Vigezzi Giacomo Pietro , Mosconi Giansanto , Gallus Silvano , Odone Anna
Published: April 2023

Background

In an ageing society, retirement impacts on behavioural risk factors and health outcomes should be carefully assessed. Scant evidence exists from longitudinal studies on the short- and long-term consequences of the transition to retirement on smoking habit.

Methods

We conducted a longitudinal study based on the Survey of Health, Ageing and Retirement in Europe (SHARE) data from 27 European countries plus Israel collected in 2004–2020. To estimate relative risks (RR) and corresponding 95% confidence intervals (CI) for smoking status and intensity at seven time periods before and after retirement, we fitted adjusted generalised estimating equation (GEE) models for repeated measures.

Results

We selected a cohort of 8998 individuals employed at baseline and retired at follow-up (median follow-up time: 9 years; maximum: 16 years). As compared to the year of retirement, the RR of smoking was 1.59 (95% CI 1.44–1.76) at 10 years or more before retirement, 1.35 (95% CI 1.25–1.46) from 5 to 9 years before retirement, and 1.18 (95% CI 1.10–1.27) from 1 to 4 years before retirement. Smoking steadily decreased after retirement, being 0.94 (95% CI 0.87–1.01) from 1 to 4 years after retirement, 0.76 (95% CI 0.69–0.84) from 5 to 9 years, and 0.58 (95% CI 0.46–0.74) 10 years or more after retirement. In smokers, the estimated number of cigarettes smoked/day decreased from about 27 cigarettes/day at 10 years or more before retirement to 9 cigarettes/day at 10 years or more after retirement (p trend < 0.001).

Conclusion

Longitudinal data suggest that lifestyles might favourably change with retirement. Further studies are needed to direct healthy ageing promotion policies better.
Explicating affordances in travel information search: investigating device use in relation to goals and personal characteristics
Authors: Zarezadeh Zohreh , Benckendorff Pierre , Gretzel Ulrike
Published: April 2023

Despite increasing attention to technology development and its impact on travel information search, research about information search behaviours across multiple devices (i.e., smartphones, laptops, tablets, and desktop computers) has received limited attention. Guided by technology affordance theory, this paper examines the link between device use and information search goals, and the relationship between personal characteristics and device use. The study is based on two independent studies. Data were collected using a mixed-methods approach utilising an online survey and an online trip planning diary. The findings revealed that information searchers were essentially multi-device users and switched between devices based on their information search goals. Moreover, personal characteristics such as demographic characteristics, experience and personality influenced device use. The findings of the research shed light on the elusive concept of affordance to enhance the understanding of the complexity of device usage during travel information search.
A stereo spatial decoupling network for medical image classification
Authors: You Hongfeng , Yu Long , Tian Shengwei , Cai Weiwei
Published: April 2023

Deep convolutional neural network (CNN) has made great progress in medical image classification. However, it is difficult to establish effective spatial associations, and always extracts similar low-level features, resulting in redundancy of information. To solve these limitations, we propose a stereo spatial discoupling network (TSDNets), which can leverage the multi-dimensional spatial details of medical images. Then, we use an attention mechanism to progressively extract the most discriminative features from three directions: horizontal, vertical, and depth. Moreover, a cross feature screening strategy is used to divide the original feature maps into three levels: important, secondary and redundant. Specifically, we design a cross feature screening module (CFSM) and a semantic guided decoupling module (SGDM) to model multi-dimension spatial relationships, thereby enhancing the feature representation capabilities. The extensive experiments conducted on multiple open source baseline datasets demonstrate that our TSDNets outperforms previous state-of-the-art models.
Red tape and industry dynamics: a cross-country analysis
Authors: Tomasi Chiara , Pieri Fabio , Cecco Valentina
Published: April 2023

In this paper, we analyze the relationship between the stringency of red tape and the entry and exit rates of firms. To do so, we use a panel dataset on firm entry and exit rates, obtained from Eurostat Business Demography, covering 22 European countries and 14 manufacturing sectors observed over the period 2013–2019. We complement the information on firm dynamics with country-level data on red tape from the World Bank’s Doing Business database. Five dimensions of red tape are considered: regulations for starting a business, construction permits, procedures for getting electricity, registering property, and contract enforcement. In addition, both the cost and the time taken to complete the administrative procedures are used as metrics of red tape. Using a difference-in-difference approach à la Rajan and Zingales (1998), we find a negative effect of administrative burdens on the entry and exit rates of firms across European countries. Moreover, we find that the negative effect is more pronounced for smaller firms. Finally, the time taken to comply with bureaucratic procedures is a greater impediment to smooth entry and exit than the monetary costs associated with these administrative barriers.
We have Some Calves left! Socially Accepted Alternatives to the Current Handling of Male Calves from Dairy Production
Authors: Schulze Maureen , Kühl Sarah , Busch Gesa
Published: April 2023

Consumers’ actual knowledge about modern food production is limited, and their judgment is often guided by assumptions or associations that are not necessarily in line with reality. Consumers’ rather unrealistic idea of livestock farming is driven by beautiful and romanticized pictures in advertising. If confronted with the reality of modern livestock farming, consumers’ responses are mainly negative. So far, dairy farming still has a more positive image and thus is less affected by public criticism. However, if made public, some of the current production practices in dairy farming have the potential to reduce consumer acceptance which in turn can have a tremendous effect on farmers. A particularly urgent topic is the handling of male dairy calves. Such calves are often treated as surplus animals due to their low genetic merits for meat, with the risk of resulting in the deprivation of animal welfare. To maintain consumer acceptance of dairy products and find socially accepted alternatives for the handling of male calves, insights into consumer perception of current and future production practices in dairy farming are needed. Thus, the aim of this study is to analyze how consumers evaluate the current situation of male dairy calves and alternatives in male calf management. A quantitative online survey, representative for the German population in terms of gender, age, education, region, and income, was carried out with 1 194 participants in February 2022. Overall, 60% of participants were not aware of the fact that male dairy calves are less appropriate for fattening purposes. Respondents saw a clear need for alternative methods for handling male calves from dairy production. More, our results show that the use of sexed semen encounters consumer resistance, while other alternatives that were evaluated as more natural were more accepted. A cluster analysis identified 3 distinct consumer segments labelled “sexed semen opponents” (31.6%), “undecided” (30.4%), and “proponents of all alternatives” (38.0%) that differed in their acceptance of alternative handling practices of male dairy calves. The results emphasize the gap between consumers’ expectations and reality on farms and the importance of considering consumer preferences when developing future pathways for dairy farming.
Impact of droplets onto surfactant-laden thin liquid films
Authors: Constante-Amores C.R. , Kahouadji L. , Shin S. , Chergui J. , Juric D. , Castrejón-Pita J.R. , Matar O.K. , Castrejón-Pita A.A.
Published: April 2023

We study the effect of insoluble surfactants on the impact of surfactant-free droplets onto surfactant-laden thin liquid films via a fully three-dimensional direct numerical simulation approach that employs a hybrid interface-tracking/level-set method, and by taking into account surfactant-induced Marangoni stresses due to gradients in interfacial surfactant concentration. Our numerical predictions for the temporal evolution of the surfactant-free crown are validated against the experimental work by Che & Matar (Langmuir, vol. 33, 2017, pp. 12140–12148). We focus on the ‘crown-splash regime’, and we observe that the crown dynamics evolves through various stages: from the growth of linear modes (through a Rayleigh–Plateau instability) to the development of nonlinearities leading to primary and secondary breakup events (through droplet shedding modulated by an end-pinching mechanism). We show that the addition of surfactants does not affect the wave selection via the Rayleigh–Plateau instability. However, the presence of surfactants plays a key role in the late stages of the dynamics as soon as the ligaments are driven out from the rim. Surfactant-induced Marangoni stresses delay the end-pinching mechanisms to result in longer ligaments prior to their capillary singularity. Our results indicate that Marangoni stresses bridge the gap between adjacent protrusions promoting the adjacent protrusions' collision and the merging of ligaments. Finally, we demonstrate that the addition of surfactants leads to surface rigidification and consequently to the retardation of the flow dynamics.
Exploring the impact of a frontal ablation parameterization on projected 21st-century mass change for Northern Hemisphere glaciers
Authors: Malles Jan-Hendrik , Maussion Fabien , Ultee Lizz , Kochtitzky William , Copland Luke , Marzeion Ben
Published: April 2023

Marine-terminating glaciers cover more than one-fourth of the total glacierized area in the Northern Hemisphere outside the Greenland ice sheet. It is therefore crucial to ensure an adequate representation of these glaciers when projecting large-scale glacier mass changes. We investigate how the introduction of marine frontal processes in the modeling chain influences the results of mass change projections, compared to projections neglecting such processes. We find that including frontal processes reduces the projected glacier mass loss, since incorporating frontal ablation in the model's mass-balance calibration results in a decrease in marine-terminating glaciers’ sensitivity to atmospheric temperatures. We also find that retrograde bed slopes lead to increased frontal ablation as the atmosphere warms, while frontal ablation decreases if bed slopes are prograde. These opposing effects have the potential to partly cancel each other when considering large glacier ensembles. Although we do not account for potential future changes in oceanic climate yet, any effect of these would be moderated by around half of today's marine-terminating glaciers becoming land-terminating in the course of the 21st century. While we find a significant influence of ice flow parameters on our results, boundary conditions remain the largest source of uncertainty in our projections.
Association between maternal metabolic profiles in pregnancy, dietary patterns during lactation and breast milk leptin: a retrospective cohort study
Authors: Yang Chen , Guo Qianying , Cui Mingxuan , Li Xuening , Zhang Jinjuan , Peng Xiaoyu , Liu Jufen , Liu Peng , Wang Linlin
Published: April 2023

Breast milk leptin plays a potential role in preventing childhood obesity. However, the associations of breast milk leptin with maternal metabolism in pregnancy and dietary patterns during lactation are still unclear. We aimed to explore associations of breast milk leptin with maternal metabolic profiles in pregnancy and dietary patterns during lactation. A total of 332 participants were recruited for this retrospective cohort study. Breast milk samples were collected at approximately 6 weeks postpartum. Breast milk leptin and twenty-three metabolic profiles in pregnancy were measured in this study. A semi-quantitative FFQ was used to gather dietary information during lactation. Both principal component analysis and the diet balance index were used to derive dietary patterns. Among twenty-three maternal metabolic profiles, maternal serum glucose (β = 1·61, P = 0·009), γ-glutamyl transferase (β = 0·32, P = 0·047) and albumin (β = −2·96, P = 0·044) in pregnancy were correlated with breast milk leptin. All dietary patterns were associated with breast milk leptin. Given the joint effects of maternal metabolism in pregnancy and dietary patterns during lactation, only diet quality distance was significantly associated with leptin concentrations in breast milk (low level v. almost no diet problem: β = −0·46, P = 0·011; moderate/high level v. almost no diet problem: β = −0·43, P = 0·035). In conclusion, both maternal metabolism in pregnancy and dietary patterns during lactation were associated with breast milk leptin. Maternal diet balance during lactation was helpful to improve breast milk leptin concentration.