bluuebunny/crossref_metadata_2025 huggingface dataset:
La modificació creativa interna de locucions en Astèrix i la traducció al català: anàlisi d'alguns exemples
Authors: Sancho Cremades Pelegrí
Published: August 2023

Summary: This paper focuses on some examples of internal creative modification of idioms and puns and the linguistic resources used in the series Astérix in the process of translation into Catalan. The linguistic and cultural idiosyncrasy of idioms makes their translation difficult, especially if they are creatively modified, since the resulting wordplays are source language-specific. Moreover, Astérix demonstrates a high level of wordplay and cultural references that are specific for French and France. Translating idioms in a creatively modified way often entails losses in comparison with the source text. Most cases of internal creative modification are either the substitution of a word or a phrase by another one, or the modification of the idiom’s morphosyntactic structure. Resources used for translating idioms into Catalan are equivalence, calque, omission and compensation. By these means, translators try to adapt the source text to the ideal Catalan speaker in order to maintain the humorous effect in the source text. [Keywords: Astérix; comics; wordplay; translation; French; Catalan; idiom]
Unterwegs. Zum Kino von Albert Serra
Authors: Stadelmaier Philipp
Published: August 2023

Summary: Marching is an essential element in the films of Catalan director Albert Serra. But, while Don Quichotte and Sancho cross the Mancha and the Three Magi walk through a global desert, their motion is often interrupted, postponed, disturbed. That is why, through Serra’s filmography, the shots become more and more like paintings and still lives. The suspense between motion and immobility in Serra’s cinema indicates something beyond the visible movement, the visible marching and the visible paths (and maybe the visible in general): another hidden motion of the characters, the images and the film, which is still “on the way” to motion – and thus to cinema itself. [Keywords: Albert Serra; Honor de cavalleria; El cant dels ocells; Història de la meva mort; death of cinema; autothanatography; still life; painting; fiction]
La traducció de la modalitat deòntica i epistèmica del verb modal sollen en el corpus COVALT
Authors: Guzman Josep R.
Published: August 2023

Summary: This paper analyses the translations of the modal verb sollen in the corpus COVALT. First, the deontic and epistemic modality of the verb in German and Catalan are pointed out, and a taxonomy on the use of sollen is suggested. Secondly, the uses of the verb sollen and their equivalences in Catalan are examined in the corpus COVALT. A quantitative approach to the data shows that the deontic modality is frequently realized by the use of haver + de + infinitive. However, to indicate a condition or an indirect obligation, the most frequent form is the expression que + subjunctive, while the future tense is chosen to signal intention or warning. Finally, a great variety of expressions are used in the case of epistemic modality. For instance, the translators make use of the following expressions: deure + infinitive, voler + infinitive, poder + infinitive, or haver + de + infinitive. Results from the present study suggest that translators are likely to rely on standardized forms to express deontic modality, while in the case of epistemic modality they maximize their own linguistic resources. [Keywords: sollen, translation, Catalan, deontic modality, epistemic modality]
Marcadors conversacionals en la traducció literària alemany-català: also i na a Jeder stirbt für sich allein
Authors: González-Villar Alejandro , Arias-Badia Blanca
Published: August 2023

Summary: Pragmatic markers pose a challenge for professional translators, since they are signs of fictive orality, i.e. a literary device whereby authors try to confer plausibility to their dialogue. Scarce studies have been devoted to the literary translation of these units from German into Catalan. The goal of the present corpus-based study is to explore the behaviour and translation of two specific markers, i.e. also and na, in Hans Fallada’s novel Jeder stirbt für sich allein (1946) and Monton’s translation of the text (2011), from both a qualitative and a quantitative approach. Pragmatic annotation has been undertaken for all of the occurrences of each marker, as well as the solutions provided, in order to account for patterns in the literary usage and translation of these units. Keywords: Pragmatic markers, grammaticalization, pragmaticalization, na, also, fictive orality, literary translation, conversational, corpus-based research
Poesia bastida amb materials planers: Optimització del ritme en els alexandrins d'Estellés
Authors: Jiménez Jesús
Published: August 2023

Summary: Metrical phonology deals with rhythmic patterns in natural languages and also with the stress grid in poetry. According to the basic hypothesis of the optimal model we follow (v. Golston, 1998, among others), verse exemplars that meet the requirements of a set of metrical constraints are preferred and, therefore, are predicted to be more frequent. To test this hypothesis, we analyze the alexandrines from Estellés’ Llibre de meravelles and show that his metric preferences are grounded on general rhythmic constraints whose satisfaction can explain the frequency differences of the attested verse lines. In particular, we find constraints promoting more eurythmic lines and constraints which, on the contrary, seem to favor rhythmically worse patterns allowing, though, a larger portion of the vocabulary to fit in the line. Keywords: Alexandrine, metrical constraints, poetic meter, rhythm, stress, Estellés
El Corpus Oral de Madrid (CORMA): materiales para el estudio (socio)lingüístico del español coloquial actual
Authors: Enghels Renata , De Latte Fien , Roels Linde
Published: August 2023

Summary: CORMA is a corpus of peninsular Spanish including spontaneous conversations recorded in Madrid between 2016 and 2019. The corpus was compiled in order to remedy the scarce documentation of 21st century colloquial Spanish. Indeed, a short overview of the corpora of conversational Spanish shows that there is a sharp contrast between the increasing interest in linguistic phenomena representative of this variety and the availability of suitable empirical data. This paper discusses the different steps that were taken to build the dataset, and presents the main characteristics of the final CORMA corpus. It also includes an illustration of how the data can be successfully exploited through a pilot study of the rise and spread of the intensification marker mazo (de) in young speak since the beginning of the 21st century. Keywords: spoken corpus, Peninsular Spanish, CORMA, intensification, mazo (de)
Una nova aportació per a la prosa catalana del Barroc: el Capritxo de fra Tomàs Roca
Authors: Mahiques Climent Joan
Published: August 2023

Summary: This paper studies and edits the Capritxo by Friar Tomàs Roca, an almost unknown work of Catalan Baroque prose. The Capritxo is a 17th-century epistolary novel copied in the ms. 788 of the Biblioteca Valenciana Nicolau Primitiu. Due to its characteristics, this work can be compared to the Estil∙lades i amoroses lletres trameses per Bertomeu Cirlot a la sua senyora i per ella a ell. The Capritxo consists of three letters written by the graduate Sophistice plus a response from the Dr Syncathegorematice to the first mail of the former. This exchange of letters draws a story about the misfortunes of two rogues sentenced to galleys. Several Latin words, especially adverbial phrases, are regularly inserted into Capritxo’s Catalan text, thus parodying the scholastic and grandiloquent language of theologians and magistrates, and joking with wordplays which may be related to the meaning of both senders’ names. Moreover, the Capritxo criticizes not only the disproportionate severity of the torture and the sentences applied against many galley prisoners, but also the inhibition of some powerful people faced with such injustices.Keywords: Baroque, Catalan prose, editing, stuffed epistle, literary capriccio, sophism, syncathegorematic words.
The use of methotrexate in rheumatoid arthritis. Recommendations of the All-Russian public organization “Association of Rheumatologists of Russia”
Authors: Nasonov E. L. , Amirjanova V. N. , Olyunin Y. A. , Muravyev Y. V. , Baranov A. A. , Zonova E. V. , Otteva E. N. , Zagrebneva A. I. , Abdulganieva D. I. , Pchelnikova P. I.
Published: August 2023

Rheumatoid arthritis (RA) is the most frequent immunoinflammatory (autoimmune) rheumatic disease characterized by chronic erosive arthritis and systemic damage to internal organs. The data obtained in the course of basic research on deciphering the mechanisms of action of methotrexate (MT) and the materials of numerous randomized placebocontrolled trials, observational studies and national registries have strengthened the position of MT as the “gold standard” of RA pharmacotherapy and a key component of the “Treatment to Target” strategy. This was the basis for the development of new recommendations of the Association of Rheumatologists of Russia (ARR) concerning the use of MT in RA, according to which MT is considered as the drug of “choice” for induction and maintenance of remission in patients with early and advanced RA, including those who need combination therapy of MT with glucocorticoids, standard Disease-Modifying Antirheumatic Drugs (DMARDs), biologics and targeted synthetic DMARDs. Special attention is paid to the safety of MT therapy and the impact of MT on comorbid pathology associated with cardiovascular complications and interstitial lung disease. Implementation of the ARR recommendations into clinical practice will reduce the risk of disability and improve life prognosis in patients with RA.
Rituximab in the treatment of systemic sclerosis. Literature review
Authors: Garzanova L. A.
Published: August 2023

Systemic sclerosis (SSc) is one of the most severe systemic rheumatic diseases, characterized by the development of progressive skin fibrosis and damage to internal organs, accompanied by a decrease in the quality of life and high mortality. The treatment of SSc remains a difficult clinical task due to the complex pathogenesis. Nowadays therapy is complex and based on the dominant clinical and pathogenetic phenotype of SSc. However, standard therapy have limited potential to radically improve the prognosis of SSc, and often their use can lead to the development of intolerance and adverse events. In this connection, it remains relevant to study and introduce new approaches for the treatment of SSc, one of which is anti-B-cell therapy. Based on the data on the key role of B cells in the regulation of inflammatory and fibrotic processes in SSc, rituximab (chimeric monoclonal antibody to B-lymphocyte surface receptors – CD20) is increasingly being studied and used in clinical practice for the treatment of this disease. This review collects and analyzes data on the efficacy, safety and impact of rituximab on various manifestations of SSc.
Evaluation of the possibility of axial psoriatic arthritis patients meet classification criteria for axial spondyloarthritis and ankylosing spondylitis
Authors: Gubar E. E. , Korotaeva T. V. , Korsakova Y. L. , Loginova E. Yu. , Smirnov A. V. , Sukhinina A. V. , Urumova M. M. , Glukhova S. I.
Published: August 2023

Objective – to analyze whether axial psoriatic arthritis (axPsA) patients meet classification criteria for axial spondyloarthritis (axSpA) and ankylosing spondylitis (AS).Subjects and methods. 104 patients (66 men and 38 women) with PsA according to CASPAR criteria were examined, all patients had back pain. Patients were evaluated for presence of inflammatory back pain (IBP) by ASAS criteria. Back pain not meeting the ASAS criteria was taken to be chronic back (chrBP). Patients underwent hands, feet and pelvis, cervical spine and lumbar spine X-rays. Erosions, osteolysis, and periarticular osteo-proliferative lesions were evaluated. Radiographically significant sacroiliitis (r-sSI) was defined as bilateral grade ≥2 or unilateral grade ≥3. 19 patients without r-sSI underwent sacroiliac joints MRI. 93 patients underwent HLA B27 examination. The number of patients who met the criteria for axSpA (ASAS) and the modified New York (mNY) criteria for AS was determined.Results. IBP was identified in 67 (64.4%), chrBP in 37 (35.6%) patients; 31 (29.8%) patients were of advanced age (over 40) at the onset of IBP/chrBP; 57 (58.8%) cases had r-sSI; 6 (31.6%) patients had MRI-SI; syndesmophytes were detected in 57 (58.8%) cases. Among 40 patients without r-sSI, 19 (47.5%) had syndesmophytes. In 38 (39.2%) out of 97 patients r-sSI was detected along with syndesmophytes, while 19 (19.6%) out of 97 patients had isolated r-sSI without spondylitis, and 19 (19.6%) out of 97 patients had isolated syndesmophytes without r-sSI. HLA B27 was present in 28 (30.1%) cases. 51 (55.4%) patients met criteria for axSpA. 41 (44.6%) patients didn’t meet criteria for axSpA, however 27 (65.9%) of them had syndesmophytes. 48 (48.5%) PsA patients met mNY criteria for AS.Among these patients a set of specific features was revealed: 18 (37.5%) had no IBP, 18 (37.5%) were of advanced age (over 40) at the onset of IBP/ chrBP, 34 (70.8%) had dactylitis, 38 (79.2%) – erosive polyarthritis, 23 (48.8%) – periarticular osteo-proliferative lesions, 14 (30.2%) – osteolysis, 23 (48,9%) – “chunky” non-marginal syndesmophytes, 40 (82,6%) – nail psoriasis, 28 (66,6%) patients were HLA-B27 negative.Conclusion. 45% of axPsA patients don’t meet criteria for axSpA. Characteristic features have been identified to differentiate axPsA from AS.
Hygienic assessment of mycological contamination of the internal environment of residential and public buildings
Authors: Kalinina Natalia V. , Zagainova Anzhelika V. , Yudin Sergey M. , Gaponova Elena B. , Banin Ilya M.
Published: August 2023

The paper presents the results of a comprehensive hygienic assessment of the fungal contamination of the internal environment of the premises of residential and public buildings and developed proposals for the methodology for conducting mycological examination of indoor air and building structures.
Materials and methods. The objects of research were urban atmospheric air, residential apartments, and office premises with and without fungal infection of wall structures, medical premises for various purposes. The studies included determination of the number of microscopic fungi in 1 m3 of air (CFU/m3); determination of the content of viable fungal flora in scrapings and in swabs from places suspected of having a fungal infection; measurements of humidity of enclosing structures and microclimatic parameters of the indoor air environment; evaluation of the ventilation system.
Results. The concentration of microscopic fungi in indoor air without fungal infection of wall structures was shown to depend on fungal pollution of atmospheric air. The peak of fungal air pollution in unaffected rooms and the ambient air, was detected over the spring-summer season. In residential apartments and office premises of public buildings with fungal infection of wall structures, the content of microscopic fungi in the air, regardless of the season, was tens and hundreds of times higher than the content of fungal flora in the air of “healthy” premises and in the atmospheric air. Fungal air pollution in residential and office premises is mainly associated with fungi of the Penicillium, Aspergillus, Cladosporium and Rizopus genera in wards, treatment and diagnostic rooms – yeast-like fungi of the genus Candida.
Limitations. The results of the study do not apply to the production facilities of biological industry enterprises, livestock and poultry complexes.
Conclusion. The necessity of conducting a mycological examination of premises has been substantiated, and a draft of methodological recommendations for conducting mycological examinations of indoor air and building structures has been developed.
Effects of daily exposure to peat smoke on the reproductive and nervous systems in male white rats
Authors: Vokina Vera A. , Sosedova Larisa M. , Novikov Mikhail A. , Andreeva Elizaveta S. , Titov Evgeniy A. , Rukavishnikov Viktor S. , Savchenkov Mikhail F.
Published: August 2023

Introduction. The regular occurrence of large-scale peat fires is an urgent medical and environmental problem of the modern scientific community. The peat smoke is a complex mixture of pollutants that have a serious impact on air quality and public health.
Materials and methods. Adult male rats were exposed to peat smoke for 24 hours, the concentrations of PM2.5 and CO were 0.92±0.08 mg/m3 and 40.8±1.9 mg/m3, respectively. After exposure an open field examination, EEG examination and histological analysis of the testes and brain were performed, after which they were mated with intact females. Postnatal death of offspring in the first week of life, body weight, behaviour and electroencephalography indicators during puberty were evaluated.
Results. There was showed an increase in motor activity, anxiety, and violation of EEG indicators in rat males exposed to peat smoke. Both an increase in shadow cells and degeneratively altered neurons in the nervous tissue were found. No changes were detected in the testes. Exposure to peat smoke during conception increased stillbirth and mortality of offspring during the first week of life, but did not affect weight gain. Violation of behaviour structure was recorded only in females offspring. An increase in slow-wave activity of the brain in males offspring was revealed.
Limitations. The study was limited to studying the effects of a single 24-hour exposure to peat smoke on outbred white rats.
Conclusion. A single peat smoke exposure for 24 hours at a concentration of PM2.5=0.92±0.08 mg/m3 and CO=40.8±1.9 mg/m3 leads to significant morphological and functional changes in the CNS. In the absence of a gonadotoxic effect, peat smoke exposure on males before mating causes specific changes in the behavior and bioelectrical activity of the brain of their offspring.
Personalized prediction of the probability of developing arterial hypertension and coronary heart disease in miners with anthracosilicosis using an automated system
Authors: Panev Nikolay I. , Filimonov Sergey N. , Panev Roman N. , Evseeva Natalya A. , Korotenko Olga Yu.
Published: August 2023

Introduction. The remaining high level of production-related cardiovascular morbidity necessitates timely preventive measures. The development of an automated forecasting technique will make it possible to implement personalized and differentiated approaches in the prevention of cardiovascular pathology in persons in contact with harmful production factors.
Materials and methods. The object of the study were workers employed in underground coal mining: One hundred sixty eight miners with previously diagnosed anthracosilicosis and 151 miners of the control group without lung pathology (a total of 319 people). Identification of diseases of the circulatory system and risk factors was carried out using clinical, laboratory, instrumental methods. The Bayes method was used to develop a forecasting system. The forecasting software as developed in the Lazarus environment using object-oriented programming methods.
Results. The most informative markers associated with a high probability of developing arterial hypertension and coronary heart disease in workers with anthracosilicosis have been identified. A software “Automated system for personalized prediction of the probability of developing arterial hypertension and coronary heart disease in miners with anthracosilicosis” has been developed. An automated forecasting system determines the degree of risk of diseases based on the results of the sum of prognostic coefficients.
Limitations. The limitation of the study was related to the sample of coal mine workers examined in the clinic of the Institute, namely: age from 40 to 54 years, long-term (more than 15 years) work experience in harmful working conditions. The study did not include miners who had other occupational diseases besides anthracosilicosis.
Conclusions. An automated system of personalized forecasting ensures the formation of high cardiovascular risk groups with minimal time costs, which allows starting primary prevention of cardiological pathology in a timely manner.
Analysis of polymorphic loci of candidate genes in patients with occupational diseases
Authors: Chernyak Yury I. , Merinova Alla P.
Published: August 2023

Introduction. Development and progress features of vibration syndrome (VS) and noise-induced hearing loss (NIHL) are determined by genetic factors to a certain extent. The latter define the relevance of the search for individual approaches to  prevention and medical support of patients with these occupational diseases.
The aim of the study was to investigate the genotypes distribution of polymorphic loci of candidate genes in patients with occupational diseases caused by vibration and noise impact.
Materials and methods. Polymorphic variants of the HSPA1B (rs1061581), IL17A (rs2275913), IL10 (rs1800872), and TNF-α (rs1800629) genes of three hundred ninety eight males were studied using PCR-RFLP and real-time PCR methods, including 268  patients with VS divided into two groups: VShtv (n = 117) and VScomb (n = 151), in which VS was caused by exposure to hand-transmitted vibration (HTV) or combined exposure to HTV and whole-body vibration (COMB), respectively. The study also involved 96 patients with occupational NIHL diagnosis and 34 individuals of the comparison group without occupational contact with physical factors.
Results. The increase in GG-HSPA1B (1267A/G) genotype frequency  (p=0.058) was found in VScomb patients compared with those from the VShtv group. There was a significant difference in carriers of the C/C genotype of the IL10 (rs1800872) polymorphic locus in the group of NIHL patients relative to the comparison group (p=0.036). The results of regression analysis indicate the carriage of the A allele to reduce the risk of NIHL development.
Limitations. The limitations include the number of examined cases in all groups, especially in comparison group and the lack of groups of workers with no occupational exposure to a physical factor.  
Conclusion. The obtained results expand the understanding of the genetic features able to determine sensitivity to the physical factors exposure that define the development of occupational pathology and the issues to be resolved at the next stage of research.
Features of the use of ischemic preconditioning for the correction of vibration polyneuropathy of the upper extremities
Authors: Yamshchikova Anastasia V. , Fleishman Arnold N. , Martynov Ilya D. , Bychkovskaya Tatiana A. , Kungurova Alla A.
Published: August 2023

Introduction. The study of the methods for non-pharmacological correction of vibration polyneuropathy is relevant in view of the high prevalence of vibration disease in various industries, and high occurrence of disability of workers. Ischemic preconditioning has shown its effectiveness in correcting the manifestations of vibration polyneuropathies. The high frequency of nerve compression in tunnels against the background of polyneuropathic lesions in vibration disease dictates the need to study the effectiveness of the method in various forms of vibration polyneuropathy.
The aim of the study was to investigate the effectiveness of ischemic preconditioning in various forms of vibration polyneuropathy.
Materials and methods. Twenty nine patients with a proven diagnosis of vibration disease were examined and treated uisng the ischemic preconditioning. They were divided into 2 groups: group 1 – 18 individuals with upper extremities polyneuropathy without nerve compression, group 2 – 11 subjects with compression complications of polyneuropathy. The examinations included neurological survey, electroneuromyographic investigation before and after the course of ischemic preconditioning conducted according to a patented technique.
Results. A decrease in sensory disturbances and improvement in the impulse conduction along the sensory fibers of the nerves of the upper extremities after a course of ischemic preconditioning in the group of the patients without compression neuropathies were noted. In the group of the patients with polyneuropathies complicated by the nerve compression in tunnels, the positive effect was less significant.
Limitations. The study was limited by the assessment of clinical and electroneuromyographic parameters in 29 patients with vibration disease due to the exposure to local vibration before and after the course of ischemic preconditioning.
Conclusion. The method of ischemic preconditioning is effective as a method for non-pharmacological correction of vibration polyneuropathy. Compression neuropathies are predictors of lower efficiency of the method, and therefore it is important to select patients for the treatment by this method with the preferred inclusion of the patients with uncomplicated vibration polyneuropathies.
Approaches to the antimicrobial susceptibility testing of Campylobacter to monitor the spread of antibiotic-resistant strains
Authors: Kosilova Irina S. , Domotenko Lyubov’ V. , Polosenko Ol’ga V. , Trukhina Galina M.
Published: August 2023

Introduction. Campylobacteriosis is one of the most common diarrhea-associated infections over the world. The situation is getting worse along with increasing cases of the disease caused by the Campylobacter spp. pathogen resistant to antimicrobials (AMPs). Preventing the disease requires monitoring the spread of resistant Campylobacter strains isolated from both sick people and animals, food, and water.
Aim of the study is to evaluate the results of the antimicrobial susceptibility testing of Campylobacter according to the requirements of the EUCAST and CLSI methodologies using Russia-made nutrient media.
Materials and methods. Collected and freshly isolated strains of C. jejuni, C. coli, C. fetus and C. lari were used. Campylobacter cultures were subcultured on Campylobacter Agar Base (HiMedia), Preston laboratory-produced medium and iron-erythritol blood agar (Obolensk). Their sensitivity to AMPs was determined by three methods as ffollows: disc diffusion, gradient diffusion and microdilutions using Mueller-Hinton agar, and broth of two manufacturers (BD BBL and Obolensk) according to EUCAST and CLSI.
Results. Using Russian-made and imported Mueller-Hinton agar and broth allowed obtaining identical results for AMPs susceptibility of Campylobacter spp. The campylobacter strains were attributed to the same susceptibility category by all three methods in frame of any methodology (EUCAST or CLSI) when interpreting results. Due to differences in cutoffs of MIC and inhibition zone diameters in the EUCAST and CLSI standards, there were some differences in the interpretation of the results.
Limitations. Eight strains of four species Campylobacter were tested for their susceptibility to three antimicrobials by three methods according to EUCAST and CLSI methodology.
Conclusion. The results obtained confirm the possibility of applying a complex of domestic nutrient media for cultivating and monitoring the spread of antibiotic resistant strains of Campylobacter spp. This is especially important in view of implementing the import substitution program.
Assessment of the neurotoxic effect of iron (III) oxide nanoparticles at the subcellular level
Authors: Shelomentsev Ivan G. , Amromin Lev A. , Shaikhova Daria R. , Sutunkova Marina P. , Minigalieva Ilzira A.
Published: August 2023

Introduction. Both naturally occurring and artificially produced nanoparticles are ubiquitous; their high concentrations can be detected in the environment, thus posing risks of toxic effects in humans. Penetrating the blood-brain barrier by metal nanoparticles has been already proven and is currently of interest from the point of view of toxicology and hygiene.
Materials and methods. Female rats were exposed to ferric oxide nanoparticles administered intranasally with a 25 mg/ml suspension at a dose of 50 µl three times a week during six weeks. The experimental and control groups contained seven animals each. Tissue samples for testing were taken from the olfactory bulbs of the rat’s brain. Iron (III) oxide nanoparticles were identified by electron microscopy and energy-dispersive X-ray spectroscopy. The cytotoxic effect of ferric oxide nanoparticles was assessed by ranking mitochondria by mitochondrial membrane morphotypes and comparing their distribution in the experimental and control groups.
Results. We confirmed the presence of nanoparticles in tissues of the olfactory bulbs of the exposed rodents. The morphotype pattern of mitochondria showed significant changes following the exposure to ferric oxide nanoparticles: the proportion of mitochondria with normal and vesicular swollen morphotypes decreased by 36.4 and 4.9%, respectively, compared with the control group of animals, the proportion of mitochondria with normal vesicular and vesicular morphotypes increased by 19.8 and 21.8%, while the proportion of vesicular swollen mitochondria decreased from 9.5% to 4.6%.
Limitations. The study was limited to examining ultrastructural changes in mitochondria and identifying ferric oxide nanoparticles in tissues.
Conclusions. Further studies of the impact of iron-containing nanoparticles on the structure and functions of the mitochondrial apparatus can help to identify their potential harm at the subcellular level and provide information for the development of appropriate health protective measures and new strategies for prevention and treatment of metal toxicity-induced diseases in humans.
Toxicological and hygienic assessment of modern thermo-insulating polymer materials during thermal exposure
Authors: Tolkach Pavel G. , Basharin Vadim A. , Shilov Yurii V. , Yazenok Arkadii V. , Antushevich Alexandr E. , Zagorodnikov Gennadii G.
Published: August 2023

Introduction. Polyethylene and synthetic foam caoutchouc are used for thermal insulation of communications, at temperatures not exceeding 90 °C and 105 °C, respectively. Data on how these materials will behave in the appropriate temperature conditions was not be found.
The purpose of the study was to conduct a toxicological and hygienic assessment of products made of polyethylene foam and synthetic foam rubber under thermal exposure.
Materials and methods. The thermal effect on the studied samples was modelled in a climate chamber. The time interval during the mass loss of the samples was determined, a sanitary and chemical study of the gas-air mixture in the climatic chamber was carried out. To conduct a toxicological and hygienic study in animals, a swim-escape conditioned active avoidance response was developed.
Results. Under thermal (90 °C) exposure for 72 hours to polyethylene tube, a loss of 0.77% of the initial mass of the sample occurs. Thermal exposure (105 °C) to synthetic foam caoutchouc resulted in a loss of 15.3% of the initial mass of the sample for 108 hours, while pronounced changes in the appearance of the samples were determined. When conducting a sanitary and chemical study in the climate chamber, an increase in the concentration of carbon monoxide was determined after 12, 24,  and 72 hours and hydrogen chloride after 12 and 24 hours following the onset of thermal exposure compared with the values of their average daily maximum permissible concentration. Thermal exposure to the sample and synthetic foam caoutchouc led to an increase in the concentration of ammonia, carbon monoxide and hydrogen chloride 12 and 24 hours after the start of exposure compared with the average daily maximum permissible concentration. During the toxicological and hygienic study, animals exposed to thermal degradation products of the materials under study were revealed to show learning disabilities.
Limitations. They are conditioned by the methodology of the study. A quantitative analysis of some gaseous thermal degradation products released into the climate chamber was performed, without taking into account the aerosols formed.
Conclusion. Thermal insulation materials made of synthetic foam rubber and polyethylene foam lose their structural properties when they are operated in the maximum permissible temperature conditions (105 °C and 90 °C, respectively). When they are used in appropriate temperature conditions, the formation of toxic products occurs, the inhalation effect of which leads to a disturbances of the learning ability in laboratory animals.
ANALISIS YURIDIS TANGGUNG RENTENG WANPRESTASI DALAM PERJANJIAN KERJA PEMBANGUNAN PERUMAHAN (Studi Putusan Mahkamah Agung RI Nomor 286 K/Pdt/2019)
Authors: Darul Ihsan Muhammad Ajri , Lubis Yamin , Akhyar Adil
Published: August 2023

Wanprestasi dalam pelaksanaan perjanjian merupakan fenomena yang sering terjadi dalam praktek. Penulisan tesis ini menggunakan metode telaah pustaka (library research). Jenis data penelitian ini adalah data sekunder dan disusun secara sistematis dan untuk mentelaah data-data sekunder menggunakan pendekatan yuridis normatif dan dianalisis secara kualitatif. Kesimpulan dari pembahasan bahwa pertimbangan  hukum hakim dalam putusan Mahkamah Agung Nomor 286 K/Pdt/2019 adalah Dodi Kuswandi bertindak selaku Kepala Zidam IV/Diponegoro dan bukan dalam kapasitasnya sebagai pribadi, sehingga segala perbuatan yang berkaitan dengan perjanjian pengadaan material beton untuk pembangunan rumah dinas tersebut, dihubungkan dengan peruntukan bangunan untuk rumah dinas dan sumber dana pembangunan berasal dari Anggaran Pendapatan dan Belanja Negara (APBN) tahun anggaran 2013, maka dengan sendirinya perjanjian yang dibuat oleh Dodi Kuswandi adalah selaku Kepala Zidam IV/Diponegoro bukan sebagai pribadi.
D-Ribose-L-Cysteine Attenuated Polychlorinated Biphenyls Mediated Neuroendocrine-Transmembrane Ionic Pump ATPase Disruption and Peroxynitrite Formation in a Rat Model: A Possible Role of Testicular Antioxidant and Androgenic Enzymes
Authors: Obukohwo Oyovwi Mega , Edesiri Tesi Prince , Benneth Ben-Azu , Victor Emojevwe , Adebayo Ojetola Abodunrin , Uchechukwu Joseph G. , Oghenetega Onome Bright , Rume Rotu Arientare , Simon Ovuakporaye Irikefe , Agbonifo-Chijiokwu Ejime , Kingsley Nwangwa Eze , Faith Falajiki Yewande , Godwin Okwute Patrick
Published: August 2023

The very hazardous and persistent aquatic pollutants known as polychlorinated biphenyls (PCBs) are known to bioaccumulate in a range of marine mammals. Human and animal studies have shown that exposure to PCBs affects the male reproductive system. This study was conducted to investigate the therapeutic effects of D-ribose-L-cysteine (DRLC) on PCB-mediated ATPase disruption of the neuroendocrine transmembrane ion pump and peroxynitrite formation in rat models. After the first 15 days of PCB treatment, DRLC (50 mg/kg) was administered orally for 15 days, beginning on day 16 and continuing through day 30. PCB (2 mg/kg) was administered for 30 days. All tests were performed in accordance with accepted procedures. Kisspeptin (kissp), gonadotropin-releasing hormone alkaline phosphatase (ALP), lactate dehydrogenase (LDH), glutathione peroxidase (GSH-Px), and total antioxidant capacity (TAOC) were all analyzed in blood on day 31. The testes were also removed and sent for testosterone, testicular antioxidant enzymes (L-C and PrDx-4), androgenic enzymes (3β-HSD and 17β-HSD), sulfhydryl content, and transmembrane ion pump (Na+, K+, Ca2+, Mg2+, and H+ ions) The results of the study showed that Kisspeptin, GnRH, Testosterone, L-C, PrDx-4, 3-HSD, 17-HSD, HOST, Na+, K+, Ca2+, Mg2+, and H+-ATPase levels were significantly increased by DRLC. In addition, DRLC therapy dramatically reduced levels of ONOO-, H2O2, 8-OHdG, ALP, and LDH, while increasing TAOC to restore GSH-Px levels. The results of the present study suggest that DRLC is a potentially effective therapeutic approach to reduce PCB-induced neuroendocrine transmembrane ion pump disruption in an experimental rat model. The primary mechanism underlying this effect may be its antioxidant activities against the formation of peroxynitrite and elevated levels of hydrogen peroxide.
HIGHLIGHTS

DRLC abates PCBs-induced peroxynitrite stress in rats’ testes
DRLC abates PCBs-induced sulphydryl depletion in rats’ testes
DRLC ameliorated PCB-induced alteration in testicular ionic ATPase pumps
DRLC enhances testicular antioxidant enzymes in rats treated with PCBs
DRLC reversed PCB-induced decreased spermatogenesis in rats’ testes

GRAPHICAL ABSTRACT
Alteraciones en los parámetros hematológicos y anormalidades morfológicas en células sanguíneas en pacientes hospitalizados con COVID-19.
Authors: Aro Pedro , Paredes Rodrigo , Sánchez Jacinto Billy , Estrada Sharon , Reyes Sandy , Tokumura Carmen
Published: August 2023

Antecedentes. La enfermedad por coronavirus (COVID-19) causada por el virus SARS-CoV-2, ha originado una crisis de salud pública mundial y presenta un importante impacto sobre el sistema hematopoyético. Objetivo. Describir las alteraciones en los parámetros hematológicos y las anomalías morfológicas en las células sanguíneas de pacientes hospitalizados con COVID-19. Materiales y métodos. Se realizó un estudio transversal basado en la revisión de 133 hemogramas y frotis de sangre periférica de pacientes mayores de 18 años hospitalizados con COVID-19 entre enero y marzo del 2021 en el Hospital Cayetano Heredia, Lima, Perú. El recuento de células sanguíneas se realizó mediante un hemograma y la morfología mediante frotis sanguíneo utilizando la técnica de tinción de Wright. Se realizó un análisis descriptivo basado en frecuencias. Resultados. El 60,9% (n=81) fueron de sexo masculino. En el hemograma, las alteraciones más frecuentes fueron neutrofilia (65,4%), anemia (64,7%), leucocitosis (60,9%), linfopenia (59,4%), eosinopenia (51,9%) y trombocitosis (27,8%). En la morfología de los hematíes, la anisocitosis (18,8%) fue la alteración más frecuente. A nivel de la morfología leucocitaria, observamos granulaciones tóxicas (51,1%), hipersegmentación de neutrófilos (32,3%), linfocitos reactivos (15%) y anomalía adquirida de Pelger Hüet (APHA) (9%) y, a nivel plaquetario, plaquetas gigantes (33,8%) fue la alteración más observada. Conclusiones. Nuestro estudio describe una variedad de alteraciones en el recuento y morfología de las células de sangre periférica en pacientes hospitalizados con COVID-19.
Mielopoyesis anormal transitoria: a propósito de un caso
Authors: Borda Sabrina , Barboza FM , Noroña PL , Sosa P , Awdejczuk Goncalves A , Moran LE
Published: August 2023

La mielopoyesis anormal transitoria (MAT) es una proliferación clonal única caracterizada por megacarioblastos inmaduros en el hígado fetal, sangre periférica y medula ósea, que ocurre en el 5 a 10% de los recién nacidos con síndrome de Down (SD). Aunque la mayoría de los pacientes experimentan una remisión espontanea, aproximadamente el 20% de los casos de MAT resultan en una muerte prematura y el 20% de los sobrevivientes desarrollan leucemia mieloide aguda (LMA) en un plazo de 4 años. A continuación se describe el caso clínico de un paciente con MAT con el objetivo de analizar los avances clínicos y biológicos recientes, como así también su implicancia en el manejo clínico.
PERCEPÇÕES DA EQUIPE DA ESTRATÉGIA SAÚDE DA FAMÍLIA EM RELAÇÃO A ATUAÇÃO DA EQUIPE DE SAÚDE BUCAL
Authors: Medeiros Mikaele Garcia de , Fernandes Eloisa Cesario , Dantas Maiara Bezerra , Simplício Gomes Pereira Hallissa , Diogenes Alves Uchoa Lins Ruthineia , Policarpo da Silva Alexandre
Published: August 2023

Introdução: A Equipe de Saúde Bucal (ESB) foi inserida na atenção básica por causa da necessidade de melhoria dos índices epidemiológicos e para possibilitar a ampliação ao acesso da população às ações a ela relacionadas. Entretanto, a incorporação da ESB em esfera nacional adveio somente oito anos após a criação da Estratégia Saúde da Família (ESF), numa tentativa de reorganizar o modelo de oferta de cuidado em saúde bucal na Atenção Primária à Saúde (APS), buscando romper com a prática odontológica excludente, tecnicista e biologicista. A ESB deve, portanto, trabalhar com as equipes multiprofissionais e interdisciplinares da ESF, para que compreendam os problemas de saúde, de uma forma ampliada, e possam intervir reconhecendo no indivíduo um sujeito biopsicossocial. Objetivo: Avaliar a percepção dos profissionais da ESF acerca da atuação da ESB na atenção básica. Métodos: Pesquisa foi qualitativa de amostragem intencional, por conveniência, composta por enfermeiros, médicos, técnicos de enfermagem, agentes comunitários de saúde de cada ESF inserida nas Unidades Básicas de Saúde (UBS) onde a Residência Multiprofissional em Atenção Básica está implementada, e a coleta de dados foi realizada através de uma entrevista semiestruturada. A análise dos dados foi realizada por meio da técnica de análise de conteúdo de Bardin. Resultados: Os resultados apontaram que todos os profissionais entrevistados reconhecem a importância da Equipe de Saúde Bucal na Estratégia Saúde da família. Conclusão: Não houve como dissociar a saúde bucal da saúde integral do ser humano, todos os profissionais das ESF entrevistados consideraram a importância da ESB na ESF.
Finance and the World Economy in Weimar Cinema
Authors: Lyons Owen
Published: August 2023

After the First World War, the effects of financial crisis could be felt in all corners of the newly formed Weimar Republic. The newly interconnected world economy was barely understood and yet it was increasingly made visible in the films of the time. The complexities of this system were reflected on screen to both the everyday spectator as well as a new class of financial workers who looked to popular depictions of speculation and crisis to make sense of their own place on the shifting ground of modern life. Finance and the World Economy in Weimar Cinema turns to the many underexamined depictions of finance capital that appear in the films of 1920s Germany. The representation of finance capital in these films is essential to our understanding of the culture of the Weimar Republic – particularly in the relation between finance and ideas of gender, nation and modernity. As visual records, these films reveal the stock exchange as a key space of modernity and coincide with the abstraction of finance as a vast labour of representation in its own right. In so doing, they introduce core visual tropes that have become essential to our understanding of finance and capitalism throughout the twentieth century.
The Stock Exchange as a Space of Modernity and Labour of Representation
Authors: Lyons Owen
Published: August 2023

Chapter 1 establishes central debates and cultural codes specific to the context of this study – in particular the close association of finance capital with anxieties surrounding France, Jews, and the importance of the historical separation of gambling from speculation. It lays the groundwork for the critical examination of these codes in Weimar cinema. This chapter also lays out two key claims: firstly, that stock exchanges have been overlooked as central spaces of modernity alongside more canonical examples such as the late nineteenth-century shopping arcade, the railroad, the street, and the cinema; and secondly, that financial markets are engaged in the creation of an image of the world – a labour of representation – the history of which parallels the development of the cinema itself.
The Aggregate Image and the World Economy
Authors: Lyons Owen
Published: August 2023

Chapter 5 turns to the emergence of the ‘aggregate image’ in the cinema and economic discourse of the Weimar Republic. It discusses Eisenstein’s plans for a film based on Marx’s Das Kapital and Brecht’s unfinished play Jae Fleischhacker in Chikago (1924), which attempted to dramatize the grain market. Discovered fragments of Balázs’s K 13 513: Die Abenteuer eines Zehnmarkscheins (‘Adventures of a Ten Mark Note’ or ‘Uneasy Money,’ 1926) – the first ‘cross-section film’ – are discussed along with Kuhle Wampe, oder: Wem gehört die Welt? (‘Kuhle Wampe, or: Who Owns the World?,’ 1932). The visual convention of the Querschnitt (‘cross-section’), a radical montage aesthetic, was emptied of its political content in the creation of a corporate vision of the world economy in Melodie der Welt (‘Melody of the World,’ 1929). The cinematic ‘aggregate image’ of the world is placed alongside parallel developments in economics that were used to create an image of the world economy.
Sheen: Early stories and circulation of shellac
Authors: Roy Elodie A.
Published: August 2023

Chapter 1 investigates the early uses, cultural understandings and traditional applications of lac and shellac as visual media in India (where it was notably used to decorate the body in practices of self-inscription). It retraces how the materials were imported by Dutch merchants and the British East India Company in the early 1600s, paying attention to the geopolitical infrastructure which authorised its circulation. The chapter describes how the medium was speculatively translated, transformed and reinterpreted in the European context. In particular, attention is paid to the reflective and imitative properties of the medium – and to the intuition of its sonic properties (when Italian violin makers began using it to varnish musical instruments).
Crackle: Assembling the record
Authors: Roy Elodie A.
Published: August 2023

Chapter 2 retraces how shellac progressively and predominantly became a medium of sound in the late nineteenth century, focusing on Emile Berliner’s discovery of its sonic properties. The chapter especially focuses on the US where the material was progressively domesticated and ‘Americanised’, to the point of erasing its provenance and premediatic histories. An important aspect of this chapter is that it makes visible the forms of labour entombed in the commodity of the record. It offers a parallel between shellac production in Indian workshops and the work carried out in western pressing plants, notably insisting on the crucial contribution of female labourers in the early phonographic industry.
Detonations: Shellac at war
Authors: Roy Elodie A.
Published: August 2023

Chapter 4 attends to the toxic transformation of shellac in the two World Wars, when it became a key substance in the manufacture of detonating compositions, hand grenades, and bombs and was rationed by governments (thus curtailing record-making operations and intensifying research into substitutes, including PVC). Drawing from Catherine Malabou’s radical theses on ‘destructive plasticity’, it theorises the material and ideological instability of shellac as well as its recycling, exploring the dominant discourses associated with recorded sound. In particular, it draws attention to the trope of phonographic listening as a means to repair both individual and social bodies broken down by war, showing how this discourse was recuperated by governmental bodies.
Introduction: From material culture to the materials of culture
Authors: Roy Elodie A.
Published: August 2023

The introductory chapter surveys the main theoretical concerns and themes underpinning the book as well as giving a brief historical overview of what shellac is. It gives insights into the chosen methodological framework, surveying what the implications of following the mutable materials – and stories – of media cultures are. Rather than focusing on finite media objects and practices of consumption, the introduction highlights what an emphasis on materials and processes might mean for the study of media cultures.