bluuebunny/crossref_metadata_2025 huggingface dataset:
Supp. Figure 1 from Targeted AKT Inhibition in Prostate Cancer Cells and Spheroids Reduces Aerobic Glycolysis and Generation of Hyperpolarized [1-13C] Lactate
Authors: Tee Sui Seng , Suster Izabela , Truong Steven , Jeong Sangmoo , Eskandari Roozbeh , DiGialleonardo Valentina , Alvarez Julio A. , Aldeborgh Hannah N. , Keshari Kayvan R.
Published: April 2023

Proton NMR spectra of LnCAP cell extracts treated either with DMSO or 1uM MK2206 for 24 hr. Co-factor concentrations were quantified as a ratio between the resonance for the lone hydrogen atom on the five membered ring of the adenine moiety in NAD+ that resonates at 8.435 ppm and NADH at 8.486 ppm. Extractions of cells were performed as described in the materials section.
Supp Figure Captions from Targeted AKT Inhibition in Prostate Cancer Cells and Spheroids Reduces Aerobic Glycolysis and Generation of Hyperpolarized [1-13C] Lactate
Authors: Tee Sui Seng , Suster Izabela , Truong Steven , Jeong Sangmoo , Eskandari Roozbeh , DiGialleonardo Valentina , Alvarez Julio A. , Aldeborgh Hannah N. , Keshari Kayvan R.
Published: April 2023

Supp Figure Captions
Figure S7 from Epigenetic Silencing of THY1 Tracks the Acquisition of the Notch1–EGFR Signaling in a Xenograft Model of CD44+/CD24low/CD90+ Myoepithelial Cells
Authors: Montanari Micaela , Carbone Maria Rita , Coppola Luigi , Giuliano Mario , Arpino Grazia , Lauria Rossella , Nardone Agostina , Leccia Felicia , Trivedi Meghana V. , Garbi Corrado , Bianco Roberto , Avvedimento Enrico V. , De Placido Sabino , Veneziani Bianca Maria
Published: April 2023

Thy1 expression in breast carcinoma and metastasis tissue
Table S1 from YAP Tyrosine Phosphorylation and Nuclear Localization in Cholangiocarcinoma Cells Are Regulated by LCK and Independent of LATS Activity
Authors: Sugihara Takaaki , Werneburg Nathan W. , Hernandez Matthew C. , Yang Lin , Kabashima Ayano , Hirsova Petra , Yohanathan Lavanya , Sosa Carlos , Truty Mark J. , Vasmatzis George , Gores Gregory J. , Smoot Rory L.
Published: April 2023

Table of primers used
S1-S5 and Table I -VII from FOXD3 Regulates CSC Marker, DCLK1-S, and Invasive Potential: Prognostic Implications in Colon Cancer
Authors: Sarkar Shubhashish , O'Connell Malaney R. , Okugawa Yoshinaga , Lee Brian S. , Toiyama Yuji , Kusunoki Masato , Daboval Robert D. , Goel Ajay , Singh Pomila
Published: April 2023

Supplementary Figure 1. Diagrammatic representation of cis-elements, including FOXD3 binding-sites in the IntronV (Î²) promoter of hDCLK1. Supplementary Figure 2. Generation of the mutant DCLK1-S-Luc1 construct for the promoter-reporter assays, for assessing the role of the functional FOXD3 binding sites in regulating the expression of the short-isoform. Supplementary Figure 3. Disease free survival of patients with CRC, in relation to relative expression levels of DCLK1-S/L and FOXD3. Supplementary Figures4A-D. Relative levels of DCLK1-S/FOXD3 staining in consecutive sections of adenomas from low- vs high-risk patients from a pilot retrospective study. SupplementaryFigure5. Relative levels of DCLK1-S/FOXD3 staining in the adenomas from low-/high-risk patients, presented as either % area or % epithelial cells stained in the samples. Supplementary Table I. Oligonucleotide (primer) sequences used for qRT-PCR/RT-PCR/ChIP/promoter-reporter assays. Supplementary Table II. The indicated human colon cancer cell lines and normal epithelial cells (HEK293, CCD841) were obtained and confirmed as described in Methods, and processed for analyzing relative expression levels of the long and short transcripts of DCLK1, along with FOXD3, by RT-PCR. Supplementary Table IIIA. Human patient samples from the normal colonic mucosa and colonic adenocarcinomas were obtained from the University of Alabama Core Facility as described in Methods, and processed for RT-PCR as described in the Legends of Figure 1D and E. Supplementary Table IIIB. Human patient samples were obtained from either UTMB or UAB, as described in Methods, as FFPE blocks, and processed for making tissue sections and staining for FOXD3, as described in the legend of Figure 2. Supplementary Table IV. Colon cancer cell lines (HCT-116, DLD1, HT-29, RKO) and the embryonic epithelial cell line (HEK-293) were processed for detecting the presence or absence of the indicated transcripts by RT-PCR, before (control) or after 5â€™-Azacytidine treatment, as described in the legend for Figure 1F. Supplementary Table V. Clinical pathological variables and DCLK1-S and FOXD3 expression in the adenocarcinomas from 92 CRC patients. Supplementary Table VIA. Samples were obtained from patients with colonic adenocarcinomas at CRC stages of I-III from 67 patients in Japan, as described in Methods. Supplementary Table VIB. Multi-variant analysis for predictors of Disease Free survival. Supplementary Table VIIA. The gender, age and ethnicity and colonoscopy history of low-risk patients from whom polyps were obtained, as tabulated. Supplementary Table VIB. The age, gender and ethnicity of the high-risk patients and the colonoscopy history, before the patients developed adenocarcinomas (AdCAs), is presented as described under Table VIA.
Supplementary Table 1 from Nucleoside Diphosphate Kinase-3 (NME3) Enhances TLR5-Induced NFκB Activation
Authors: Flentie Kelly , Gonzalez Caleb , Kocher Brandon , Wang Yue , Zhu Hongtu , Marasa Jayne , Piwnica-Worms David
Published: April 2023

Supplementary Table 1. Library Hits.
Supplementary Figure Legends from Nucleoside Diphosphate Kinase-3 (NME3) Enhances TLR5-Induced NFκB Activation
Authors: Flentie Kelly , Gonzalez Caleb , Kocher Brandon , Wang Yue , Zhu Hongtu , Marasa Jayne , Piwnica-Worms David
Published: April 2023

Supplementary Figure Legends
Figure S2 from Combinations of Tyrosine Kinase Inhibitor and ERAD Inhibitor Promote Oxidative Stress–Induced Apoptosis through ATF4 and KLF9 in Medullary Thyroid Cancer
Authors: Bagheri-Yarmand Rozita , Sinha Krishna M. , Li Ling , Lu Yue , Cote Gilbert J. , Sherman Steven I. , Gagel Robert F.
Published: April 2023

Eeyarestatin in combination with sunitinib synergistically induce cell death in MZCRC1 spheres
Supplemental table 1 from Integrative Epigenetic and Gene Expression Analysis of Renal Tumor Progression to Metastasis
Authors: Nam Hye-Young , Chandrashekar Darshan S. , Kundu Anirban , Shelar Sandeep , Kho Eun-Young , Sonpavde Guru , Naik Gurudatta , Ghatalia Pooja , Livi Carolina B. , Varambally Sooryanarayana , Sudarshan Sunil
Published: April 2023

Supplemental Table 1. Location of metastasis used for array analysis
Table S1 from Diffuse Intrinsic Pontine Glioma Cells Are Vulnerable to Mitotic Abnormalities Associated with BMI-1 Modulation
Authors: Senthil Kumar Shiva , Sengupta Satarupa , Zhu Xiaoting , Mishra Deepak Kumar , Phoenix Timothy , Dyer Lisa , Fuller Christine , Stevenson Charles B. , DeWire Mariko , Fouladi Maryam , Drissi Rachid
Published: April 2023

Histone mutation and BMI-1 expression (log2 fold change) of patient tumor section used for IHC in figure S1A.
Figure S1 from Novel Aberrations Uncovered in Barrett's Esophagus and Esophageal Adenocarcinoma Using Whole Transcriptome Sequencing
Authors: Maag Jesper L.V. , Fisher Oliver M. , Levert-Mignon Angelique , Kaczorowski Dominik C. , Thomas Melissa L. , Hussey Damian J. , Watson David I. , Wettstein Antony , Bobryshev Yuri V. , Edwards Melanie , Dinger Marcel E. , Lord Reginald V.
Published: April 2023

Tissue purity, RNA-seq based correlation analysis, and gene ontology enrichment. ESTIMATE (see methods) was used for in silico assessment of the (a) tissue purity, (c) stromal contamination, and (b) immune infiltration of each patient from the Normal esophagus (NE), Non-dysplastic Barrett's esophagus (NDBE), Low-grade dysplasia (LGD) and Esophageal adenocarcinoma (EAC) group. (d) Scatterplot comparing the mean expression (log2(cpm 1)) of all Gencode genes between each condition. Spearman correlation (R) shows the correlation score. (e) Venn diagram of the differentially expressed (absolute log2FC{greater than or equal to}1, FDR
Figure S5 from Diffuse Intrinsic Pontine Glioma Cells Are Vulnerable to Mitotic Abnormalities Associated with BMI-1 Modulation
Authors: Senthil Kumar Shiva , Sengupta Satarupa , Zhu Xiaoting , Mishra Deepak Kumar , Phoenix Timothy , Dyer Lisa , Fuller Christine , Stevenson Charles B. , DeWire Mariko , Fouladi Maryam , Drissi Rachid
Published: April 2023

Survival probability of mice post-drug withdrawal starting from drug holiday. P values are indicated, *p<0.05.
Figure S3 from Inhibition of Aurora-A Promotes CD8+ T-Cell Infiltration by Mediating IL10 Production in Cancer Cells
Authors: Han Jing , Jiang Zhen , Wang Chennan , Chen Xin , Li Rongqing , Sun Na , Liu Xiangye , Wang Hui , Hong Li , Zheng Kuiyang , Yang Jing , Ikezoe Takayuki
Published: April 2023

Figure S3 shows the population of intratumoral B cells and macrophages in either control-treated or alisertib-treated tumors.
Supplementary Table S3 from Landscape of Tumor Mutation Load, Mismatch Repair Deficiency, and PD-L1 Expression in a Large Patient Cohort of Gastrointestinal Cancers
Authors: Salem Mohamed E. , Puccini Alberto , Grothey Axel , Raghavan Derek , Goldberg Richard M. , Xiu Joanne , Korn W. Michael , Weinberg Benjamin A. , Hwang Jimmy J. , Shields Anthony F. , Marshall John L. , Philip Philip A. , Lenz Heinz-Josef
Published: April 2023

Published immune checkpoint inhibitor (ICI) response rate in gastrointestinal cancers.
Figure S1 from NME1 Drives Expansion of Melanoma Cells with Enhanced Tumor Growth and Metastatic Properties
Authors: Wang Ying , Leonard M. Kathryn , Snyder Devin E. , Fisher Matthew L. , Eckert Richard L. , Kaetzel David M.
Published: April 2023

Expression of NME1 and NME2 mRNAs after treatment with lentiviral vectors expressing shNME1a and shNME1b.
Suppl Data & Figures from ADAM12 Is a Novel Regulator of Tumor Angiogenesis via STAT3 Signaling
Authors: Roy Roopali , Dagher Adelle , Butterfield Catherine , Moses Marsha A.
Published: April 2023

Supplementary file includes the following Extended methods: Immunohistochemitry and Chondrosarcoma model Supplementary Table I: Reference genes and genes of interest for qRT-PCR analysis Supplementary Table II: List of differentially expressed angiogenic-regulator genes in ADAM12-expressing breast tumor cells (BTC) Suppl. Fig. 1: ADAM12 expression in EC Suppl. Fig. 2: Effect of metalloprotease inhibitor on EC recruitment by ADAM12-expressing BTC Suppl. Fig. 3: Effect of ADAM12 silencing on angiogenic regulator expression levels in BTC Suppl. Fig. 4: ADAM12 expression in T47-D cells results in upregulated VEGF levels and downregulated TSP1 and TIMP-2 levels Suppl. Fig. 5: Downregulation of endogenous ADAM12 expression in MDA-MB-436 Suppl. Fig. 6: mRNA expression correlation analysis of ADAM12 with angiogenic regulators in human breast tumor tissue Suppl. Fig. 7: pSTAT3 levels are upregulated in ADAM12-expressing T47-D and MDA-MB-231 BTC Suppl. Fig. 8: Downregulation of STAT3 and EGFR results in significant downregulation of EC recruitment by ADAM12-expressing BTC
Figure S8 from UNC-45A Is a Novel Microtubule-Associated Protein and Regulator of Paclitaxel Sensitivity in Ovarian Cancer Cells
Authors: Mooneyham Ashley , Iizuka Yoshie , Yang Qing , Coombes Courtney , McClellan Mark , Shridhar Vijayalakshmi , Emmings Edith , Shetty Mihir , Chen Liqiang , Ai Teng , Meints Joyce , Lee Michael K. , Gardner Melissa , Bazzaro Martina
Published: April 2023

Linear range for quantitative Western blot analysis
Figure S4 from UNC-45A Is a Novel Microtubule-Associated Protein and Regulator of Paclitaxel Sensitivity in Ovarian Cancer Cells
Authors: Mooneyham Ashley , Iizuka Yoshie , Yang Qing , Coombes Courtney , McClellan Mark , Shridhar Vijayalakshmi , Emmings Edith , Shetty Mihir , Chen Liqiang , Ai Teng , Meints Joyce , Lee Michael K. , Gardner Melissa , Bazzaro Martina
Published: April 2023

Depletion of UNC-45A using a second shRNA-UNC-45A (#2) causes mitotic defects consistent with overly stable mitotic spindles
Figure S3 from UNC-45A Is a Novel Microtubule-Associated Protein and Regulator of Paclitaxel Sensitivity in Ovarian Cancer Cells
Authors: Mooneyham Ashley , Iizuka Yoshie , Yang Qing , Coombes Courtney , McClellan Mark , Shridhar Vijayalakshmi , Emmings Edith , Shetty Mihir , Chen Liqiang , Ai Teng , Meints Joyce , Lee Michael K. , Gardner Melissa , Bazzaro Martina
Published: April 2023

The UNC-45A antibody is specific in immunofluorescence
Supplementary Figure 2 from Synthetic Lethality of PARP Inhibition and Ionizing Radiation is p53-dependent
Authors: Sizemore Steven T. , Mohammad Rahman , Sizemore Gina M. , Nowsheen Somaira , Yu Hao , Ostrowski Michael C. , Chakravarti Arnab , Xia Fen
Published: April 2023

Supplemental figure demonstrating BRCA1 shuttling in response to radiation in vivo requires p53.
Supplementary Figure 6. (B-C) from Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk
Authors: Petitalot Ambre , Dardillac Elodie , Jacquet Eric , Nhiri Naima , Guirouilh-Barbat Josée , Julien Patrick , Bouazzaoui Isslam , Bonte Dorine , Feunteun Jean , Schnell Jeff A. , Lafitte Philippe , Aude Jean-Christophe , Noguès Catherine , Rouleau Etienne , Lidereau Rosette , Lopez Bernard S. , Zinn-Justin Sophie , Caputo Sandrine M.
Published: April 2023

FBTSA assays performed to measure binding of the mutated BRCA1 BRCT domains to ACC1-P, BACH1-P, CtiP-P, AB-1P and AB-2P.
Supplementary Figure 1 from Synthetic Lethality of PARP Inhibition and Ionizing Radiation is p53-dependent
Authors: Sizemore Steven T. , Mohammad Rahman , Sizemore Gina M. , Nowsheen Somaira , Yu Hao , Ostrowski Michael C. , Chakravarti Arnab , Xia Fen
Published: April 2023

Supplemental Figure illustrating BRCA1 is excluded from the nuclei following radiation in a p53-dependent manner.
Supplementary Figure 4. (A-D) from Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk
Authors: Petitalot Ambre , Dardillac Elodie , Jacquet Eric , Nhiri Naima , Guirouilh-Barbat Josée , Julien Patrick , Bouazzaoui Isslam , Bonte Dorine , Feunteun Jean , Schnell Jeff A. , Lafitte Philippe , Aude Jean-Christophe , Noguès Catherine , Rouleau Etienne , Lidereau Rosette , Lopez Bernard S. , Zinn-Justin Sophie , Caputo Sandrine M.
Published: April 2023

Isothermal Titration Calorimetry curves obtained by adding the different phosphopeptides at (A-B) 200 mM onto the WT BRCT domains at 20 mM and (C-D) 100 mM onto the WT BRCT domains at 10 mM .
Supplementary Figure 3. Classification of the 42 purified mutated BRCT domains as a function of their thermostability as measured using a high throughput fluorescence assay. from Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk
Authors: Petitalot Ambre , Dardillac Elodie , Jacquet Eric , Nhiri Naima , Guirouilh-Barbat Josée , Julien Patrick , Bouazzaoui Isslam , Bonte Dorine , Feunteun Jean , Schnell Jeff A. , Lafitte Philippe , Aude Jean-Christophe , Noguès Catherine , Rouleau Etienne , Lidereau Rosette , Lopez Bernard S. , Zinn-Justin Sophie , Caputo Sandrine M.
Published: April 2023

The black bar corresponds to WT BRCA1, the blue bars to VUS of classes 1 and 2, the grey bars to VUS of class 3 and the red bars to VUS of classes 4 and 5. Bars boxed in green correspond to mutants that are defective in phosphopeptide-binding, as observed using fluorescence based thermal shift assays. HR- marks VUS that are HR-defective.
Figure S4 from The Tissue-Reconstructing Ability of Colon CSCs Is Enhanced by FK506 and Suppressed by GSK3 Inhibition
Authors: Ishida Ryo , Koyanagi-Aoi Michiyo , Oshima Nobu , Kakeji Yoshihiro , Aoi Takashi
Published: April 2023

Knock down of GSK3α and GSK3β by siRNAs.
Supplementary Table 1 from A Role for Tryptophan-2,3-dioxygenase in CD8 T-cell Suppression and Evidence of Tryptophan Catabolism in Breast Cancer Patient Plasma
Authors: Greene Lisa I. , Bruno Tullia C. , Christenson Jessica L. , D'Alessandro Angelo , Culp-Hill Rachel , Torkko Kathleen , Borges Virginia F. , Slansky Jill E. , Richer Jennifer K.
Published: April 2023

Summary of patient data
Supplementary Table 2 from Adaptive Resistance to EGFR-Targeted Therapy by Calcium Signaling in NSCLC Cells
Authors: Mulder Celine , Prust Nadine , van Doorn Sander , Reinecke Maria , Kuster Bernhard , van Bergen en Henegouwen Paul , Lemeer Simone
Published: April 2023

Raw Proteins
Supplementary Tables 1-3 from Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer
Authors: Baker Kathryn T. , Nachmanson Daniela , Kumar Shilpa , Emond Mary J. , Ussakli Cigdem , Brentnall Teresa A. , Kennedy Scott R. , Risques Rosa Ana
Published: April 2023

Table S1. Patient Information. Table S2. Biopsy Information. Table S3. Mutation Information.
Supplementary Material and Methods from Adaptive Resistance to EGFR-Targeted Therapy by Calcium Signaling in NSCLC Cells
Authors: Mulder Celine , Prust Nadine , van Doorn Sander , Reinecke Maria , Kuster Bernhard , van Bergen en Henegouwen Paul , Lemeer Simone
Published: April 2023

Supplementary Material and Methods
Supplementary Figures from Adaptive Resistance to EGFR-Targeted Therapy by Calcium Signaling in NSCLC Cells
Authors: Mulder Celine , Prust Nadine , van Doorn Sander , Reinecke Maria , Kuster Bernhard , van Bergen en Henegouwen Paul , Lemeer Simone
Published: April 2023

Supplementary Figures S1-S3
Supplementary Figures 1-12 from Mitochondrial DNA Mutations are Associated with Ulcerative Colitis Preneoplasia but Tend to be Negatively Selected in Cancer
Authors: Baker Kathryn T. , Nachmanson Daniela , Kumar Shilpa , Emond Mary J. , Ussakli Cigdem , Brentnall Teresa A. , Kennedy Scott R. , Risques Rosa Ana
Published: April 2023

Figure S1.Histology of UC colon tissue. Figure S2. Clonal expansions Figure S3. Clonal and Subclonal Mutations by Biopsy Figure S4. Association between mutation number and total DCS nucleotides sequenced. Figure S5. Association of Clonal and Subclonal Mutations with Clinical Variables. Figure S6. MAF of individual clonal and subclonal mutations. Figure S7. C>A Mutation Frequencies by Biopsy. Figure S8. Association of Very Low Frequency Mutations with clinical variables. Figure S9. Mutation Signature by Mutation Type. Figure S10. VLF transitions and transversions by mtDNA Region and biopsy type. Figure S11. VLF mutation frequency and Gene Size. Figure S12. Model of mitochondrial mutation progression during UC carcinogenesis.
Supplementary Figure 1 from S-Nitrosylation of EGFR and Src Activates an Oncogenic Signaling Network in Human Basal-Like Breast Cancer
Authors: Switzer Christopher H. , Glynn Sharon A. , Cheng Robert Y.-S. , Ridnour Lisa A. , Green Jeffrey E. , Ambs Stefan , Wink David A.
Published: April 2023

PDF file - 2.5MB, LEF binding elements are prevalent in human breast cancer NOS2-associated gene expression
Supplementary Materials and Methods, Figure Legends 1-5 from The Hedgehog Receptor Patched Functions in Multidrug Transport and Chemotherapy Resistance
Authors: Bidet Michel , Tomico Amandine , Martin Patrick , Guizouarn Hélène , Mollat Patrick , Mus-Veteau Isabelle
Published: April 2023

PDF file - 97K
Supplementary Figure 4 from The Activation of MEK/ERK Signaling Pathway by Bone Morphogenetic Protein 4 to Increase Hepatocellular Carcinoma Cell Proliferation and Migration
Authors: Chiu Chiang-Yen , Kuo Kung-Kai , Kuo Tzu-Lei , Lee King-The , Cheng Kuang-Hung
Published: April 2023

PDF file - 399K
Supplementary Figure 3 from The Activation of MEK/ERK Signaling Pathway by Bone Morphogenetic Protein 4 to Increase Hepatocellular Carcinoma Cell Proliferation and Migration
Authors: Chiu Chiang-Yen , Kuo Kung-Kai , Kuo Tzu-Lei , Lee King-The , Cheng Kuang-Hung
Published: April 2023

PDF file - 32K
Supplementary Methods from IGF2 Autocrine-Mediated IGF1R Activation Is a Clinically Relevant Mechanism of Osimertinib Resistance in Lung Cancer
Authors: Manabe Tadashi , Yasuda Hiroyuki , Terai Hideki , Kagiwada Harumi , Hamamoto Junko , Ebisudani Toshiki , Kobayashi Keigo , Masuzawa Keita , Ikemura Shinnosuke , Kawada Ichiro , Hayashi Yuichiro , Fukui Kazuhiko , Horimoto Katsuhisa , Fukunaga Koichi , Soejima Kenzo
Published: April 2023

Supplementary Methods includes 4 methods: "Preparation of cell lysates for protein array", "Phosphorylation activity measurement on the array", "Estimation of active pathway by protein array" and "Software".
Supplementary Figures S1-S6 from IGF2 Autocrine-Mediated IGF1R Activation Is a Clinically Relevant Mechanism of Osimertinib Resistance in Lung Cancer
Authors: Manabe Tadashi , Yasuda Hiroyuki , Terai Hideki , Kagiwada Harumi , Hamamoto Junko , Ebisudani Toshiki , Kobayashi Keigo , Masuzawa Keita , Ikemura Shinnosuke , Kawada Ichiro , Hayashi Yuichiro , Fukui Kazuhiko , Horimoto Katsuhisa , Fukunaga Koichi , Soejima Kenzo
Published: April 2023

Supplementary Figures includes 6 figures. Supplementary Figure S1: Bypass pathway activation detected using a protein array confers resistance in PC9 cells. Supplementary Figure S2: IGF2-IGF1R activation contributes to acquired resistance to osimertinib in PC9AZDR cells. Supplementary Figure S3: Elucidation of MET amplification as a resistant mechanism in KOLK17 and KOLK37 cells. Supplementary Figure S4: IGF2-IGF1R bypass pathway contributes to acquired resistance in osimertinib-resistant PDCs. Supplementary Figure S5: Quantities of IGF2 reduce in a drug-free medium in KOLK43 cells. Supplementary Figure S6: Effect of combination therapy in vivo.
Supplementary Figure S1 from Mitogen-Activated Protein Kinase Kinase 4/c-Jun NH2-Terminal Kinase Kinase 1 Protein Expression Is Subject to Translational Regulation in Prostate Cancer Cell Lines
Authors: Robinson Victoria L. , Shalhav Ore , Otto Kristen , Kawai Tomoko , Gorospe Myriam , Rinker-Schaeffer Carrie W.
Published: April 2023

Supplementary Figure S1 from Mitogen-Activated Protein Kinase Kinase 4/c-Jun NH2-Terminal Kinase Kinase 1 Protein Expression Is Subject to Translational Regulation in Prostate Cancer Cell Lines
Supplementary Methods, Figures Legends 1-7 from Inhibition of the Hedgehog Pathway Targets the Tumor-Associated Stroma in Pancreatic Cancer
Authors: Hwang Rosa F. , Moore Todd T. , Hattersley Maureen Mertens , Scarpitti Meghan , Yang Bin , Devereaux Erik , Ramachandran Vijaya , Arumugam Thiruvengadam , Ji Baoan , Logsdon Craig D. , Brown Jeffrey L. , Godin Robert
Published: April 2023

PDF file - 78K
Supplementary Table 4 from The Lymphotactin Receptor Is Expressed in Epithelial Ovarian Carcinoma and Contributes to Cell Migration and Proliferation
Authors: Kim Mijung , Rooper Lisa , Xie Jia , Rayahin Jamie , Burdette Joanna E. , Kajdacsy-Balla Andre A. , Barbolina Maria V.
Published: April 2023

PDF file - 38K, Expression of XCR1 in specimens of metastatic ovarian carcinoma
Supplementary Table 3 from The Lymphotactin Receptor Is Expressed in Epithelial Ovarian Carcinoma and Contributes to Cell Migration and Proliferation
Authors: Kim Mijung , Rooper Lisa , Xie Jia , Rayahin Jamie , Burdette Joanna E. , Kajdacsy-Balla Andre A. , Barbolina Maria V.
Published: April 2023

XLS file - 69K, Expression of XCR1 in specimens of ovarian carcinoma and normal ovary
Table S1 from Metastasis-Specific Gene Expression in Autochthonous and Allograft Mouse Mammary Tumor Models: Stratification and Identification of Targetable Signatures
Authors: Ross Christina , Szczepanek Karol , Lee Maxwell , Yang Howard , Peer Cody J. , Kindrick Jessica , Shankarappa Priya , Lin Zhi-Wei , Sanford Jack D. , Figg William D. , Hunter Kent W.
Published: April 2023

Samples for RNAseq analysis
Figure S3 from Metastasis-Specific Gene Expression in Autochthonous and Allograft Mouse Mammary Tumor Models: Stratification and Identification of Targetable Signatures
Authors: Ross Christina , Szczepanek Karol , Lee Maxwell , Yang Howard , Peer Cody J. , Kindrick Jessica , Shankarappa Priya , Lin Zhi-Wei , Sanford Jack D. , Figg William D. , Hunter Kent W.
Published: April 2023

Work flow for identification of metastasis specific gene expression analysis
Supplementary Figure 8 from TLE1 Is an Anoikis Regulator and Is Downregulated by Bit1 in Breast Cancer Cells
Authors: Brunquell Chris , Biliran Hector , Jennings Scott , Ireland Shubha Kale , Chen Renwei , Ruoslahti Erkki
Published: April 2023

PDF file - 392K, MCF10-CA1a and HOP-92 cells were treated with iRGD-CDD or etoposide (20uM).
Supplementary Figures S1-S8 from Geldanamycin-Induced Down-Regulation of ErbB2 from the Plasma Membrane Is Clathrin Dependent but Proteasomal Activity Independent
Authors: Pedersen Nina Marie , Madshus Inger Helene , Haslekås Camilla , Stang Espen
Published: April 2023

Supplementary Figures S1-S8 from Geldanamycin-Induced Down-Regulation of ErbB2 from the Plasma Membrane Is Clathrin Dependent but Proteasomal Activity Independent
Supplementary Figures S1-S3 from Monochromosome Transfer and Microarray Analysis Identify a Critical Tumor-Suppressive Region Mapping to Chromosome 13q14 and THSD1 in Esophageal Carcinoma
Authors: Ko Josephine M.Y. , Chan Pui Ling , Yau Wing Lung , Chan Ho Kin , Chan King Chi , Yu Zhuo You , Kwong Fung Mei , Miller Lance D. , Liu Edison T. , Yang Li Chun , Lo Paulisally H.Y. , Stanbridge Eric J. , Tang Johnny C.O. , Srivastava Gopesh , Tsao Sai Wah , Law Simon , Lung Maria L.
Published: April 2023

Supplementary Figures S1-S3 from Monochromosome Transfer and Microarray Analysis Identify a Critical Tumor-Suppressive Region Mapping to Chromosome 13q14 and THSD1 in Esophageal Carcinoma
Supplementary Table 4 from Diverse BRAF Gene Fusions Confer Resistance to EGFR-Targeted Therapy via Differential Modulation of BRAF Activity
Authors: Stangl Christina , Post Jasmin B. , van Roosmalen Markus J. , Hami Nizar , Verlaan-Klink Ingrid , Vos Harmjan R. , van Es Robert M. , Koudijs Marco J. , Voest Emile E. , Snippert Hugo J.G. , Kloosterman W.P.
Published: April 2023

Supplementary Table 4. List of BRAF (fusion) gene and GFP-specific primers. Primer used for breakpoint PCR, HA-tag spanning PCR and for the gateway cloning
Supplementary Table 1 from Diverse BRAF Gene Fusions Confer Resistance to EGFR-Targeted Therapy via Differential Modulation of BRAF Activity
Authors: Stangl Christina , Post Jasmin B. , van Roosmalen Markus J. , Hami Nizar , Verlaan-Klink Ingrid , Vos Harmjan R. , van Es Robert M. , Koudijs Marco J. , Voest Emile E. , Snippert Hugo J.G. , Kloosterman W.P.
Published: April 2023

Supplementary Table 1. KSEA kinase scores and kinase-substrate links identified in phosphoproteomic screen (provided separately due to size)
Supplementary Figure Legends from Diverse BRAF Gene Fusions Confer Resistance to EGFR-Targeted Therapy via Differential Modulation of BRAF Activity
Authors: Stangl Christina , Post Jasmin B. , van Roosmalen Markus J. , Hami Nizar , Verlaan-Klink Ingrid , Vos Harmjan R. , van Es Robert M. , Koudijs Marco J. , Voest Emile E. , Snippert Hugo J.G. , Kloosterman W.P.
Published: April 2023

Supplementary Figure Legends
Supplementary Table 2 from Suppression of G-protein–Coupled Receptor Kinase 3 Expression Is a Feature of Classical GBM That Is Required for Maximal Growth
Authors: Woerner B. Mark , Luo Jingqin , Brown Kristin R. , Jackson Erin , Dahiya Sonika M. , Mischel Paul , Benovic Jeffrey L. , Piwnica-Worms David , Rubin Joshua B.
Published: April 2023

PDF file - 48KB
Supplementary Figure Legend from EpCAM Modulates NF-κB Signaling and Interleukin-8 Expression in Breast Cancer
Authors: Sankpal Narendra V. , Fleming Timothy P. , Gillanders William E.
Published: April 2023

PDF file - 104K
Supplementary Figures 1-4, Methods from Repression of Malignant Tumor Progression upon Pharmacologic IGF1R Blockade in a Mouse Model of Insulinoma
Authors: Zumsteg Adrian , Caviezel Christoph , Pisarsky Laura , Strittmatter Karin , García-Echeverría Carlos , Hofmann Francesco , Christofori Gerhard
Published: April 2023

PDF file - 2.1MB
Supplementary Figure 3 from Protein Kinase Casein Kinase 2–Mediated Upregulation of N-Cadherin Confers Anoikis Resistance on Esophageal Carcinoma Cells
Authors: Ko Hyeonseok , Kim Seongrak , Jin Cheng-Hao , Lee Eunjung , Ham Sunyoung , Yook Jong In , Kim Kunhong
Published: April 2023

PDF file - 79K, Expression level of molecules involved in E-cadherin down-regulation. Western blot analysis was performed using total cell lysates (A) or lysates from cytoplasmic or nuclear fraction (B). The indicated Abs were used. RT-PCR was performed to examine mRNA expression level of Axin2 in TE2 and HCE4 cells and GAPDH was used as an internal control
Supplemental Figure 3 from Alternative NHEJ Pathway Components Are Therapeutic Targets in High-Risk Neuroblastoma
Authors: Newman Erika A. , Lu Fujia , Bashllari Daniela , Wang Li , Opipari Anthony W. , Castle Valerie P.
Published: April 2023

Supplemental Figure 3: NB cell lines have differential NHEJ repair protein expression patterns.
Supplementary Data 7 from Suberoylanilide Hydroxamic Acid as a Radiosensitizer through Modulation of RAD51 Protein and Inhibition of Homology-Directed Repair in Multiple Myeloma
Authors: Chen Xufeng , Wong Patty , Radany Eric H. , Stark Jeremy M. , Laulier Corentin , Wong Jeffrey Y.C.
Published: April 2023

PDF file - 627K, (A) Effects of 200 nM SAHA on mRNA expressions of DSB repair-related genes in response to IR. MM cells were treated with SAHA for 16 hours, followed by 6 Gy IR. Total RNA were prepared 3 and 24 hours later, and subjected to RPA assay with custom-designed probe sets for DNA repair protein profile. (B). Time dependent effects of SAHA on mRNA expressions. U266B1 cells were exposed to 200 nM SAHA for indicated time periods, and total RNA prepared were subjected to RPA assay. (C) Dose-dependent effects of SAHA on mRNA and protein levels of RAD51. U266B1 cells were exposed to vairous concentrations of SAHA for 16 hours, and total RNA prepared were subjected to RPA assay. Western blot shows higher concentrations of SAHA reduce RAD51 protein level in U266B1 cells
Supplementary Data 5 from Suberoylanilide Hydroxamic Acid as a Radiosensitizer through Modulation of RAD51 Protein and Inhibition of Homology-Directed Repair in Multiple Myeloma
Authors: Chen Xufeng , Wong Patty , Radany Eric H. , Stark Jeremy M. , Laulier Corentin , Wong Jeffrey Y.C.
Published: April 2023

PDF file - 364K, Cells were pretreated with 200 nM SAHA for 16 hours, and then irradiated with 6 Gy. Cells were collected at indicated time points after irradiation for immunofluorescence staining with anti-RAD51 antibody (red), and anti phosphorylated histone H2A.X (gamma-H2A.X) antibody (green). Nuclei were stained with DAPI (blue)
Supplemental Figure S2 from Elevated Slit2 Activity Impairs VEGF-Induced Angiogenesis and Tumor Neovascularization in EphA2-Deficient Endothelium
Authors: Youngblood Victoria , Wang Shan , Song Wenqiang , Walter Debra , Hwang Yoonha , Chen Jin , Brantley-Sieders Dana M.
Published: April 2023

Supplemental Figure S2: Inhibiting Slit activity rescues VEGF-induced vascular assembly and migration in EphA2 knockdown in human endothelial cells.
Supplementary Figure 2 from The E6 Oncoprotein from HPV16 Enhances the Canonical Wnt/β-Catenin Pathway in Skin Epidermis In Vivo
Authors: Bonilla-Delgado José , Bulut Gülay , Liu Xuefeng , Cortés-Malagón Enoc M. , Schlegel Richard , Flores-Maldonado Catalina , Contreras Rubén G. , Chung Sang-Hyuk , Lambert Paul F. , Üren Aykut , Gariglio Patricio
Published: April 2023

PDF file - 108K, HPV16-E6 enhances canonical Wnt/�-catenin signaling pathway in primary human keratinocytes. Wnt/�-catenin pathway activation was assessed using the TOPFLASH construct. Human foreskin keratinocytes were co-transfected with, E6, HPV16-E6�141-151 (E6�PDZ), Dvl2 and B-cat expression vectors. Both, E6 and the mutated form lacking the PDZ-binding domain (E6�PDZ), minimally activated the canonical Wnt pathway. However, both of the constructs induced very significant enhancement when they were co-transfected with Dvl2 or �-catenin (B-cat), which suggests that this effect was independent of the PDZ-binding domain.
Supplementary Figure 6 from EWS/FLI1 Regulates EYA3 in Ewing Sarcoma via Modulation of miRNA-708, Resulting in Increased Cell Survival and Chemoresistance
Authors: Robin Tyler P. , Smith Anna , McKinsey Erin , Reaves Lisa , Jedlicka Paul , Ford Heide L.
Published: April 2023

PDF file - 311K, EYA3 inhibition sensitizes SKES-1 Ewing's sarcoma cells to etoposide
Supplementary Figure 4 from EWS/FLI1 Regulates EYA3 in Ewing Sarcoma via Modulation of miRNA-708, Resulting in Increased Cell Survival and Chemoresistance
Authors: Robin Tyler P. , Smith Anna , McKinsey Erin , Reaves Lisa , Jedlicka Paul , Ford Heide L.
Published: April 2023

PDF file - 29K, miR-708 mimic is able to repress endogenous EYA3 protein levels in A673 cells at 10nM concentration
Supplementary Video 2 from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer
Authors: Hu Xiaowen , Guo Jinyi , Zheng Lan , Li Chunsheng , Zheng Tim M. , Tanyi Janos L. , Liang Shun , Benedetto Chiara , Mitidieri Marco , Katsaros Dionyssios , Zhao Xia , Zhang Youcheng , Huang Qihong , Zhang Lin
Published: April 2023

AVI file - 4558K, let-7b inhibits breast cancer cell motility�individual cell motility.
Supplementary Figure 3 from A Novel 19q13 Nucleolar Zinc Finger Protein Suppresses Tumor Cell Growth through Inhibiting Ribosome Biogenesis and Inducing Apoptosis but Is Frequently Silenced in Multiple Carcinomas
Authors: Cheng Yingduan , Liang Pei , Geng Hua , Wang Zhaohui , Li Lili , Cheng Suk Hang , Ying Jianming , Su Xianwei , Ng Ka Man , Ng Margaret H.L. , Mok Tony S.K. , Chan Anthony T.C. , Tao Qian
Published: April 2023

PDF file - 196K, ZNF545 inhibited protein translation efficiency in HONE1 cells
Supplementary Figure 1 from A Novel 19q13 Nucleolar Zinc Finger Protein Suppresses Tumor Cell Growth through Inhibiting Ribosome Biogenesis and Inducing Apoptosis but Is Frequently Silenced in Multiple Carcinomas
Authors: Cheng Yingduan , Liang Pei , Geng Hua , Wang Zhaohui , Li Lili , Cheng Suk Hang , Ying Jianming , Su Xianwei , Ng Ka Man , Ng Margaret H.L. , Mok Tony S.K. , Chan Anthony T.C. , Tao Qian
Published: April 2023

PDF file - 196K, Representative analyses of ZNF545 expression and methylation in several carcinoma cell lines
Supplementary Figure 2 from The Heterochronic microRNA let-7 Inhibits Cell Motility by Regulating the Genes in the Actin Cytoskeleton Pathway in Breast Cancer
Authors: Hu Xiaowen , Guo Jinyi , Zheng Lan , Li Chunsheng , Zheng Tim M. , Tanyi Janos L. , Liang Shun , Benedetto Chiara , Mitidieri Marco , Katsaros Dionyssios , Zhao Xia , Zhang Youcheng , Huang Qihong , Zhang Lin
Published: April 2023

PDF file - 1436K, Fig. S2. The endogenous let-7 inhibitor, LIN28, promotes breast cancer cell migration in vitro.
Supplemental Figure 3 from Exploitation of Castration-Resistant Prostate Cancer Transcription Factor Dependencies by the Novel BET Inhibitor ABBV-075
Authors: Faivre Emily J. , Wilcox Denise , Lin Xiaoyu , Hessler Paul , Torrent Maricel , He Wei , Uziel Tamar , Albert Daniel H. , McDaniel Keith , Kati Warren , Shen Yu
Published: April 2023

AR-dependent recruitment of BRD4 to ARE-enhancers.
Supplementary Video 2 from Basal-like Breast Cancer Cells Induce Phenotypic and Genomic Changes in Macrophages
Authors: Stewart Delisha A. , Yang Yinmeng , Makowski Liza , Troester Melissa A.
Published: April 2023

AVI file - 3MB, Movie of THP-1 cells engulfing latex microparticles after coculturing with SUM149 basal-like breast cancer cells
Supplementary Table 3 from Basal-like Breast Cancer Cells Induce Phenotypic and Genomic Changes in Macrophages
Authors: Stewart Delisha A. , Yang Yinmeng , Makowski Liza , Troester Melissa A.
Published: April 2023

PDF file - 103K, List of genes defined in the literature as significant in monocyte-to-macrophage differentiation and polarization.
Supplemental Figure Legends from PIK3CA and p53 Mutations Promote 4NQO-Initated Head and Neck Tumor Progression and Metastasis in Mice
Authors: García-Carracedo Darío , Cai Yi , Qiu Wanglong , Saeki Kiyoshi , Friedman Richard A. , Lee Andrew , Li Yinglu , Goldberg Elizabeth M. , Stratikopoulos Elias E. , Parsons Ramon , Lu Chao , Efstratiadis Argiris , Philipone Elizabeth M. , Yoon Angela J. , Su Gloria H.
Published: April 2023

Supplemental Figure Legends 1-4
Supplementary Data from Inhibition of TWIST1 Leads to Activation of Oncogene-Induced Senescence in Oncogene-Driven Non–Small Cell Lung Cancer
Authors: Burns Timothy F. , Dobromilskaya Irina , Murphy Sara C. , Gajula Rajendra P. , Thiyagarajan Saravanan , Chatley Sarah N.H. , Aziz Khaled , Cho Yoon-Jae , Tran Phuoc T. , Rudin Charles M.
Published: April 2023

Supplementary Data PDF file - 114K, Supplemental Table 1 Mutational status of cell lines studied
Supplementary Materials and Methods from Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression
Authors: Pirozzi Christopher J. , Carpenter Austin B. , Waitkus Matthew S. , Wang Catherine Y. , Zhu Huishan , Hansen Landon J. , Chen Lee H. , Greer Paula K. , Feng Jie , Wang Yu , Bock Cheryl B. , Fan Ping , Spasojevic Ivan , McLendon Roger E. , Bigner Darell D. , He Yiping , Yan Hai
Published: April 2023

Materials and Methods used for gene expression profiling.
Supplementary Fig. 7 from Hypoxia Attenuates Trastuzumab Uptake and Trastuzumab-Emtansine (T-DM1) Cytotoxicity through Redistribution of Phosphorylated Caveolin-1
Authors: Indira Chandran Vineesh , Månsson Ann-Sofie , Barbachowska Magdalena , Cerezo-Magaña Myriam , Nodin Björn , Joshi Bharat , Koppada Neelima , Saad Ola M. , Gluz Oleg , Isaksson Karolin , Borgquist Signe , Jirström Karin , Nabi Ivan Robert , Jernström Helena , Belting Mattias
Published: April 2023

Figure S7. Histology of primary breast cancer tissue.
Supplementary Figures 1 through 5 from Mutant IDH1 Disrupts the Mouse Subventricular Zone and Alters Brain Tumor Progression
Authors: Pirozzi Christopher J. , Carpenter Austin B. , Waitkus Matthew S. , Wang Catherine Y. , Zhu Huishan , Hansen Landon J. , Chen Lee H. , Greer Paula K. , Feng Jie , Wang Yu , Bock Cheryl B. , Fan Ping , Spasojevic Ivan , McLendon Roger E. , Bigner Darell D. , He Yiping , Yan Hai
Published: April 2023

Supplementary Figure S1: p53 is upregulated in response to mutant IDH1 induction. Supplementary Figure S2: Hierarchical clustering of top 1% variant genes. Supplementary Figure S3: Further characterization of NSC and brain tumor cell lines. Supplementary Figure S4: E18.5 tamoxifen treatment of pregnant dams promotes robust recombination in embryos. Supplementary Figure S5: D-2HG detection in brain tumor cell lines.
Supplementary Fig. 6 from Hypoxia Attenuates Trastuzumab Uptake and Trastuzumab-Emtansine (T-DM1) Cytotoxicity through Redistribution of Phosphorylated Caveolin-1
Authors: Indira Chandran Vineesh , Månsson Ann-Sofie , Barbachowska Magdalena , Cerezo-Magaña Myriam , Nodin Björn , Joshi Bharat , Koppada Neelima , Saad Ola M. , Gluz Oleg , Isaksson Karolin , Borgquist Signe , Jirström Karin , Nabi Ivan Robert , Jernström Helena , Belting Mattias
Published: April 2023

S6. CAV1 is expressed in the cytoplasm of invasive tumor cells in primary breast cancer tissue.
Supplementary Table 1 from SUZ12 Promotes Human Epithelial Ovarian Cancer by Suppressing Apoptosis via Silencing HRK
Authors: Li Hua , Cai Qi , Wu Hong , Vathipadiekal Vinod , Dobbin Zachary C. , Li Tianyu , Hua Xiang , Landen Charles N. , Birrer Michael J. , Sánchez-Beato Margarita , Zhang Rugang
Published: April 2023

XLS file - 49K, List of genes differentially expressed in SKOV3 EOC cells expressing shSUZ12 compared with controls using an apoptosis-regulating genes real-time PCR array from SA-Bioscience
Supplementary Figure 6 from SUZ12 Promotes Human Epithelial Ovarian Cancer by Suppressing Apoptosis via Silencing HRK
Authors: Li Hua , Cai Qi , Wu Hong , Vathipadiekal Vinod , Dobbin Zachary C. , Li Tianyu , Hua Xiang , Landen Charles N. , Birrer Michael J. , Sánchez-Beato Margarita , Zhang Rugang
Published: April 2023

PDF file - 314K, HRK contributes to apoptosis induced by SUZ12 knockdown
Supplementary Figure 4 from Environmental Estrogens Differentially Engage the Histone Methyltransferase EZH2 to Increase Risk of Uterine Tumorigenesis
Authors: Greathouse K. Leigh , Bredfeldt Tiffany , Everitt Jeffrey I. , Lin Kevin , Berry Tia , Kannan Kurunthachalam , Mittelstadt Megan L. , Ho Shuk-mei , Walker Cheryl L.
Published: April 2023

PDF file - 1.9MB, Effects of neonatal exposure to DES, GEN, or BPA (1, 50 or 50mg/kg, respectively for three consecutive days, PND 10-12) on adult uterine morphology. Shown are photomicrographs of hematoxylin and eosin-stained histological sections of uteri, ovaries, and vaginas from adult (3-5 months old) rats exposed neonatally to VEH (a, b and c), DES (d, e and f), GEN (g, h and i), or BPA (j, k and l) (20X). The length of scale bar is 200 �m.
Supplementary Figure 2 from SUZ12 Promotes Human Epithelial Ovarian Cancer by Suppressing Apoptosis via Silencing HRK
Authors: Li Hua , Cai Qi , Wu Hong , Vathipadiekal Vinod , Dobbin Zachary C. , Li Tianyu , Hua Xiang , Landen Charles N. , Birrer Michael J. , Sánchez-Beato Margarita , Zhang Rugang
Published: April 2023

PDF file - 857K, SUZ12 knockdown inhibits the growth of human EOC cells
Supplementary Table 1 from MiR-126 Acts as a Tumor Suppressor in Pancreatic Cancer Cells via the Regulation of ADAM9
Authors: Hamada Shin , Satoh Kennichi , Fujibuchi Wataru , Hirota Morihisa , Kanno Atsushi , Unno Jun , Masamune Atsushi , Kikuta Kazuhiro , Kume Kiyoshi , Shimosegawa Tooru
Published: April 2023

PDF file - 58KB
Supplementary Figure 1 from Acquisition of Resistance of Pancreatic Cancer Cells to 2-Methoxyestradiol Is Associated with the Upregulation of Manganese Superoxide Dismutase
Authors: Zhou Jianhong , Du Yuchun
Published: April 2023

PDF file - 177K, Mitochondria purification protocol and Western blot analysis of the purified mitochondria
Supplementary Figure 1 from Noncanonical Regulation of the Hedgehog Mediator GLI1 by c-MYC in Burkitt Lymphoma
Authors: Yoon Joon Won , Gallant Marisa , Lamm Marilyn LG , Iannaccone Stephen , Vieux Karl-Frederic , Proytcheva Maria , Hyjek Elizabeth , Iannaccone Philip , Walterhouse David
Published: April 2023

PDF file - 1257K, Supplemental Figure 1. Exposure of Burkitt lymphoma cells to SHH, IHH, or cyclopamine. (A). We do not detect changes in cell viability by MTT assay following exposure of BL1648, BL2625, or BL1647 cells to SHH peptide, or (B) cell viability by MTT assay following exposure of BL1648, BL2625, BL1647, or BL1596 cells to IHH peptide. (C). We do not detect changes in cell proliferation by BrdU incorporation following exposure of BL1648, BL2725, or BL1647 cells to SHH peptide, or (D) cell proliferation by BrdU incorporation following exposure of BL1648, BL2625, BL1647, or BL1596 cells to IHH peptide. (E). We do not detect changes in apoptosis by caspase 3/7 assay following exposure of BL1648, BL2625, or BL1647 cells to SHH peptide, or (F) apoptosis by caspase 3/7 assay following exposure of BL1648, BL2625, BL1647, or BL1596 cells to IHH peptide. (G). GLI1 mRNA expression does not change by quantitative RT-PCR following treatment of BL1648 cells (black bars) or BL1596 cells (gray bars) with the HH pathway inhibitor cyclopamine (left panel) or the negative control tomatidine (right panel) for 24 hrs. The concentration (μM) of cyclopamine or tomatidine is shown on the x-axis. (H). Cell proliferation measured by BrdU assay does not generally change following treatment of BL1648 cells (black bars), BL1596 cells (gray bars), or BL2625 cells (white bars) with cyclopamine (left panel) or tomatidine (right panel; negative control). A statistically significant reduction in cell proliferation is seen for BL1596 cells using 10 μM cyclopamine (* indicates p<0.05). A statistically significant increase in cell proliferation is seen for BL2625 cells using 10 μM tomatidine. (I). Apoptosis measured by caspase3/7 assay does not change following treatment of BL1648 cells (black bars), BL1596 cells (gray bars), or BL2625 cells (white bars) with cyclopamine (left panel) or tomatidine (right panel; negative control). A statistically significant decrease in caspase activity is seen in BL1648 cells treated with 1 μM tomatidine.
Supplementary Figure 4 from Expression of G Protein-Coupled Receptor 19 in Human Lung Cancer Cells Is Triggered by Entry into S-Phase and Supports G2–M Cell-Cycle Progression
Authors: Kastner Stefan , Voss Tilman , Keuerleber Simon , Glöckel Christina , Freissmuth Michael , Sommergruber Wolfgang
Published: April 2023

PDF file - 74K, Binding of E2F1-4 to the promoter of Gpr19. The result of chromatin immunoprecipitation is shown (full size agarose gel).
Supplementary Figure Legend from CPEB1 Regulates the Expression of MTDH/AEG-1 and Glioblastoma Cell Migration
Authors: Kochanek Dawn M. , Wells David G.
Published: April 2023

Supplementary Figure Legend PDF file - 57K, Supplementary Figure 1 Legend
Supplementary Figure 6 from Exosomal Annexin II Promotes Angiogenesis and Breast Cancer Metastasis
Authors: Maji Sayantan , Chaudhary Pankaj , Akopova Irina , Nguyen Phung M. , Hare Richard J. , Gryczynski Ignacy , Vishwanatha Jamboor K.
Published: April 2023

Signaling pathways induced by exosomal AnxA2
Supplementary Methods, Figures 1-10, Table 1 from Inhibition of mTORC1 Kinase Activates Smads 1 and 5 but Not Smad8 in Human Prostate Cancer Cells, Mediating Cytostatic Response to Rapamycin
Authors: Wahdan-Alaswad Reema S. , Bane Kara L. , Song Kyung , Shola Dorjee T.N. , Garcia Jorge A. , Danielpour David
Published: April 2023

PDF file - 953K
Supplemental Table 1 from Bacterial SOS Genes mucAB/umuDC Promote Mouse Tumors by Activating Oncogenes Nedd9/Aurkb via a miR-145 Sponge
Authors: Tanooka Hiroshi , Inoue Ayako , Takahashi Ryou-u , Tatsumi Kouichi , Fujikawa Kazuo , Nagao Tetsuji , Ishiai Masamichi , Chiwaki Fumiko , Aoyagi Kazuhiko , Sasaki Hiroki , Ochiya Takahiro
Published: April 2023

Table S1. Synthetic DNA oligomers, PCR primers
Supplementary Material and Figures 1-3 from Metformin Mitigates DPP-4 Inhibitor-Induced Breast Cancer Metastasis via Suppression of mTOR Signaling
Authors: Kawakita Emi , Yang Fan , Kumagai Asako , Takagaki Yuta , Kitada Munehiro , Yoshitomi Yasuo , Ikeda Takayuki , Nakamura Yuka , Ishigaki Yasuhito , Kanasaki Keizo , Koya Daisuke
Published: April 2023

Fig. S1 Gene expression profile analysis of primary mammary tumors in control, KR- and KR plus AMD-treated mice. Fig. S2 4T1 cells were treated with KR (50 μM) and/or metformin (10 mM) and cultured for 48 h. Fig. S3 4T1 cells were treated with KR (50 μM) and/or metformin (10 mM) and cultured for 48 h.
Supplementary Figure 3 from KRASG12D- and BRAFV600E-Induced Transformation of Murine Pancreatic Epithelial Cells Requires MEK/ERK-Stimulated IGF1R Signaling
Authors: Appleman Victoria A. , Ahronian Leanne G. , Cai JiuFeng , Klimstra David S. , Lewis Brian C.
Published: April 2023

PDF file - 618K, MEK/ERK and PI3K/AKT signaling is required for KRASG12D- and BRAFV600E-induced survival
Supplementary Figure 1 from KRASG12D- and BRAFV600E-Induced Transformation of Murine Pancreatic Epithelial Cells Requires MEK/ERK-Stimulated IGF1R Signaling
Authors: Appleman Victoria A. , Ahronian Leanne G. , Cai JiuFeng , Klimstra David S. , Lewis Brian C.
Published: April 2023

PDF file - 715K, Wild type BRAF enhances survival in response to apoptotic stimuli