bluuebunny/crossref_metadata_2025 huggingface dataset:
Handling of Family Genetic and Genomic Data: An International Legal Aspect
Authors: Kubyshkin A. V.
Published: December 2024

The paper attempts to analyze international legal acts that express approaches and principles aimed at regulating the handling of genetic and genomic data, including family data. At the international level, the processing of genetic and genomic data is regulated as part of a more general data management regulation. Meanwhile, there are documents devoted directly to the processing of genomic data. The paper analyzes specific international legal documents, including in relation to relevant acts at the level of the Russian Federation. Based on the results of the study, conclusions are drawn related to the possibility of using international legal approaches in domestic legislation. It is noted that most attempts at regulation are expressed in the norms of «soft law», which is quite consistent with the stage of development of the considered social relations. All acts aimed at regulating the processing of genetic and genomic data are aimed at finding a balance of interests between different social groups and, in any case, at finding a balance between public and private (individual) interests. Rational use of approaches formulated at the level of international organizations, taking into account the interests of the Russian Federation, will make it possible to develop proposals for improving domestic regulation in this area.
Experimental study of early protective action of live influenza vaccine against heterologous influenza infection
Authors: Petrachkova Daria S. , Rekstin Andrey R. , Mayorova Irina V. , Kopylova Nina V. , Guzenkov Danila S. , Sokolovskiy Daniil D. , Desheva Yulia A.
Published: December 2024

BACKGROUND: The live influenza vaccine is an effective means of combating influenza infection. It is characterized by ease of administration, cost-effectiveness, and rapid production, and it stimulates both systemic and local immune responses. This study investigates early protection against heterologous influenza infection within one week after immunization with the live influenza vaccine.
AIM: The aim of the study was to experimentally investigate the mechanisms of early protection against heterologous influenza infection following immunization with a live influenza vaccine.
MATERIALS AND METHODS: In in vitro experiments, we studied the production of type I interferons in a culture of monocyte-macrophage-derived cells using enzyme-linked immunosorbent assay. THP-1 cells were seeded at a concentration of 3 × 106 cells/ml, and after 48 hours, the vaccine strain of the live influenza vaccine was added. Mice were immunized intranasally under light ether anesthesia with the vaccine virus A/17/South Africa/2013/01(H1N1)pdm09, obtained from the virus collection of the Virology Department of the Institute of Experimental Medicine, at a dose of 6.0 lg EID50. Infection was performed on the 6th day after immunization with the virus A/Indonesia/5/2005(H5N1) IDCDC-RG2.
RESULTS: During the introduction of both the vaccine virus and the parental virus A/South Africa/3626/2013 (H1N1)pdm09 into THP-1 cell cultures, an increase in the production of early cytokines was observed. Immunization with the live influenza vaccine completely protected the mice from lethal infection with a heterologous influenza virus.
CONCLUSIONS: The obtained data may indicate the benefits of using the live influenza vaccine during the seasonal uptick of acute respiratory viral infections due to the stimulation of innate immune factors.
Alterations in the expression of dopamine catabolism genes in DAT-KO rats with induced valproate syndrome
Authors: Nazarov Ilya R. , Obukhova Daria A. , Kudrinskaya Valentina M. , Pestereva Nina S.
Published: December 2024

BACKGROUND: Autism spectrum disorder and attention deficit hyperactivity disorder are complex disorders of nervous development. Both diseases are diagnosed in childhood and are often comorbital. Rats with a knockout of the dopamine transporter gene (DAT) exhibit symptoms characteristic of attention deficit hyperactivity disorder. Prenatal treatment with valproic acid is used to model autism spectrum disorder. Dysfunction of the dopaminergic system may be one of the causes of attention deficit hyperactivity disorder and autism spectrum disorder. However the neurochemical mechanisms underlying dysfunction of the dopaminergic system and contributing to the pathogenesis of attention deficit hyperactivity disorder require further studies.
AIM: Therefore, the aim of the work was to investigate the expression levels of dopamine catabolism genes in heterozygous rats with a knockout of the DAT encoding gene and induced valproate syndrome.
MATERIALS AND METHODS: The work was performed on 32 rats aged 40 days (adolescence). In total, 4 groups of baby rats were formed in the study: DAT:Salt, DAT:VPA, WT:VPA and WT:Salt, where DAT/WT is the presence or absence of a genetic factor (DAT is a heterozygote for knockout of the SLC6A3 gene, WT is the wild type), VPA/Salt is the presence or absence of a toxic factor (induced valproate syndrome).
RESULTS: The expression of mRNA monoamine oxidase A and monoamine oxidase B in the midbrain was reduced in the groups DAT:Sat, DAT:VPA, WT:VPA compared to the control group WT:Salt. The expression mRNA of catechol-O-methyltransferase mRNA in the midbrain of rats DAT:Salt is significantly higher than in the control group WT:Salt, however, the treatment with valproic acid leads to a decrease in catechol-O-methyltransferase expression in heterozygous rats by knocking out the SLC6A3 gene. No changes in the expression of monoamine oxidase A, monoamine oxidase B, catechol-O-methyltransferase mRNA were observed in the prefrontal cortex and striatum.
CONCLUSIONS: The development of valproate syndrome and/or reduce dopamine reuptake leads to a decrease in the levels of monoamine oxidase A and monoamine oxidase B mRNA in the rat midbrain. Prenatal exposure to valproic acid led to a decrease in the level of catechol-O-methyltransferase mRNA in the midbrain of heterozygous rats by knockout of the DAT gene.
The correlation of morphometric and biochemical parameters in regenerating tissues of skin burn wounds in rats at assession the reparative properties of 2-ethyl-6-methyl-3-hydroxypyridinium N-acetyl-6-aminohexanoate
Authors: Petrovskaya Marina A. , Petrova Margarita B. , Egorova Elena N. , Andrianova Elena V.
Published: December 2024

BACKGROUND: Aminohexanoic acid and its derivatives are potential reparants. The study is dedicated to the assessment of the aminohexanoic acid derivative on the healing of experimental thermal skin burns.
AIM: To study the relationship between morphometric and biochemical parameters during an experiment to evaluate the effectiveness of 2% ointment with 2-ethyl-6-methyl-3-hydroxypyridinium N-acetyl-6-aminohexanoate for the treatment of skin burns in rats.
MATERIALS AND METHODS: The thermal skin burns of 25 mm2 area was modeled in 63 white non-linear sexually mature female rats under general anesthesia with Zoletil 100. The rats were divided into three groups depending on the local effect on the burn area: the control 1 group of rats — with imitation of application procedure without applying substances; the control 2 group with application of an ointment base (polyethylene glycol); the experimental group with application of 2% ointment with 2-ethyl-6-methyl-3-hydroxypyridinium N-acetyl-6-aminohexanoate. Applications of ointment, ointment base and their imitation were carried out starting from the second day until the end of the experiment. Morphometric and biochemical parameters were studied in homogenates of regenerating tissues of skin wounds on 7, 14 and 21 experiment days.
RESULTS: In experimental group rats during the inflammation phase, the efficiency of regeneration, confirmed by the dynamics of the area wounds, was largely correlated with the width of the leukocyte shaft and the thickness of granulation tissue, which, in turn, depended on the levels of Tumor Necrosis Factor alfa and Vascular Endothelial Growth Factor, respectively. In the proliferation phase, the area of wounds was significantly correlated with the length of the epithelial wedge and the fibroblasts number in the field of view, which, respectively, depended on the levels of Transforming Growth Factor beta and basic Fibroblast Growth Factor.
CONCLUSIONS: Results of the correlation analysis have testified that the reparative effect of local exposure with 2% ointment with 2-ethyl-6-methyl-3-hydroxypyridinium N-acetyl-6-aminohexanoate is ensured by activation of the synthesis of growth factors that stimulate the proliferation of capillaries and fibroblasts — components of granulation tissue, the active formation of which induces epidermis repair, which confirmed by planimetric data.
The Evaluation of The Impact of The Covid-19 Pandemic Period on Performance of Porfolio Management Companies
Authors: Ok Ergün Hilal , Aktaş Zekiye , Kurtaran Ahmet
Published: December 2024

The purpose of this study is to evaluate the relative performance of the portfolio management companies traded on BIST. Using data envelopment analysis, the study covers the period between 2019 and 2022. In the study investigating the impact of the COVID-19 pandemic period on the performance of portfolio management companies, the period of 2019 is considered as pre-COVID-19 pandemic, the years 2020 and 2021 as the COVID-19 pandemic period, and the year 2022 as the post-COVID-19 pandemic period. Within the scope of data envelopment analysis, outout oriented BCC and CCR models based on constant and variable returns to scale were used in the study and efficient firms were identified. According to the results of the CCR model based on constant returns to scale, 31% of the firms in the pre-pandemic period, 24% in the pandemic period and 17% after the pandemic achieved full efficiency. According to the results of the BCC model based on variable returns to scale, 51% of the analyzed firms continued their activities effectively before and during the pandemic, while this rate decreased to 31% in the post-pandemic period. In this context, it has been concluded that the COVID-19 pandemic period had an impact on the relative performance of portfolio management companies.
Entropi Tabanlı CoCoSo Yöntemi ile Türkiye ve Avrupa Birliği Ülkelerinin Lojistik Performanslarının Değerlendirmesi
Authors: Şişman Senay , Nebati Emine Elif
Published: December 2024

Dünya Bankası, uluslararası ticareti teşvik etmek ve rekabet gücünü artırmak amacıyla Lojistik Performans Endeksi (LPI)’ni oluşturarak önemli bir adım atmıştır. LPI sıralamaları, ülkelerin lojistik performanslarını karşılaştırmak ve çözüm önerileri geliştirmek adına önemli bir kaynaktır. Bu çalışma, Entropi tabanlı CoCoSo yöntemi ile Türkiye ve Avrupa Birliği ülkelerinin lojistik performanslarının değerlendirilmesini amaçlamaktadır. Bu doğrultuda, ilk olarak Dünya Bankası’nın belirlemiş olduğu kriterlerin ağırlıkları Entropi yöntemi ile belirlenmiştir ve en önemli kriter altyapı olmuştur. Daha sonra Türkiye ve AB ülkelerinin lojistik performans sıralamaları CoCoSo yöntemi ile gerçekleştirilmiştir. İlk sırada Finlandiya yer alırken, Macaristan son sırada yer almaktadır. Çalışmada elde edilen sıralamalar, Dünya Bankası 2023 LPI sıralamaları ile karşılaştırıldığında Finlandiya ve Almanya’nın sıralamasında değişiklik gözlenmemişken diğer ülkelerin sıralamasında çok küçük değişiklikler görülmüştür. Bu durum, çalışmada kullanılan entegre yöntemin ülkelerin lojistik performanslarını değerlendirmede güvenilir bir araç olduğunu göstermiştir.
Yatırımcı Duyarlılığı ve BIST100 Endeksi Arasındaki İlişki: Toda Yamamoto Nedensellik Uygulaması
Authors: Gül Semih , Yıldırım Salih , Hattapoğlu Mustafa
Published: December 2024

Bu çalışma, Borsa İstanbul 100 getiri endeksi ile yatırımcı duyarlılığı arasındaki ilişkiyi incelemeyi hedeflemektedir. Mayıs 2012 - Mart 2024 dönemini kapsayan bu araştırmada, BIST-100 Getiri Endeksi ile yatırımcı duyarlılığını yansıtan Tüketici Güven Endeksi (TGE), Bloomberg HT Tüketici Güven Endeksi (BLOOM), Reel Kesim Güven Endeksi (RGE), Finansal Hizmetler Güven Endeksi (FHGE), Ekonomik Güven Endeksi (EGE), CBOE Volatilite Endeksi (VIX), Risk İştahı Endeksi (RISE) ve Kredi Temerrüt Swap (CDS) göstergeleri kullanılmıştır. BIST-100 getiri endeksi ile yatırımcıların duyarlılığını ölçen göstergeler arasındaki ilişki, Toda Yamamoto (1995) testi aracılığıyla incelenmiştir. Yapılan analiz neticesinde BIST 100 getiri endeksinin hem Tüketici Güven Endeksi hem de Kredi Temerrüt Swapları ile karşılıklı bir nedensellik ilişkisinin olduğu tespit edilmiştir. Bununla birlikte Ekonomik Güven Endeksinden ve Risk İştahı Endeksinden BIST 100’e, BIST 100’den ise Bloomberg HT Tüketici Güven Endeksine doğru tek taraflı bir ilişki saptanmıştır. Diğer yandan Reel Kesim Güven Endeksi, Finansal Hizmetler Güven Endeksi, Ekonomik Güven Endeksi ve Volatilite Endeksi ile BIST100 arasında herhangi bir nedensellik ilişkisi bulunmamıştır.
John Hick’s Theodicy of Moral and Spiritual Development and a Critical Examination of Theodicy
Authors: Kalın Mehmet Fatih
Published: December 2024

John Hick is a significant philosopher known for his innovative ideas in religious thought and theology, particularly through his ‘theodicy of moral and spiritual development’. He redefines human existence as a spiritual education process orchestrated by God, suggesting that the world is created for humanity’s spiritual growth. Hick interprets pain and evil as integral parts of a divine plan, positing that these challenges allow individuals to develop through the exercise of free will. This perspective departs from traditional theistic views, framing evil as a necessary tool for spiritual advancement while maintaining the absolute goodness of God. However, Hick’s theories face criticism, particularly regarding the notion that all human pain serves an educational purpose. Critics argue that experiencing evil can result in trauma, and not all suffering fosters spiritual development. This contention highlights the limitations of Hick’s theodicy in addressing contemporary issues in religion, morality, and social trauma. Despite these criticisms, Hick’s ideas remain influential, sparking discussions among theologians and moral philosophers about the relationship between suffering, spiritual growth, and the dynamics within these fields. His work continues to inspire new approaches to understanding religion and spiritual development.
ADVANCED APPLICATIONS OF PHYSICS-INFORMED NEURAL NETWORKS (PINNS) IN R FOR SOLVING DIFFERENTIAL EQUATIONS
Authors: Agraz Melih
Published: December 2024

Deep learning, a powerful machine learning technique leveraging artificial neural networks, excels in identifying complex patterns and relationships within data. Among its innovations is the emergence of Physics-Informed Neural Networks (PINNs), which have revolutionized the field of applied mathematics by enabling the solution and discovery of differential equations through neural networks. PINNs address two key challenges: data-driven solutions, where the model approximates the hidden solutions of differential equations with fixed parameters, and data-driven discovery, where the network learns parameters that best describe observed data. This study explores the implementation of PINNs within the R programming environment to solve two differential equations: one with boundary conditions y^'-y=0 with y(0)=0 and y(e)=1 boundaries and the Burgers’ Equation. The research utilizes R libraries, including reticulate for Python integration and torch for neural network operations, to demonstrate the versatility and efficacy of PINNs in addressing both data-centric solutions and parameter discovery. The results showcase the ability of PINNs to handle complex, high-dimensional problems, offering a promising alternative to traditional numerical methods for solving differential equations.
THE OPTIMIZATION OF RAILWAY FASTENER DEFECT DETECTION VIA ACTIVATION FUNCTION ADAPTATIONS
Authors: Özdemir Rıdvan , Koç Mehmet
Published: December 2024

Manual control of rail defect detection is slow and costly. Deep learning methods can detect some of these defects to a certain extent. However, existing systems produce too many false positives due to environmental factors, resulting in labor and cost losses. One of the most important components in railway systems is the fastener, and their failure can lead to severe accidents. In this study, we developed a deep learning-based method that is designed to remain robust against foreign objects and environmental conditions when detecting railway fasteners. By employing various activation functions and expanding the training dataset through data augmentation techniques, our method significantly reduces false alarms. The best-performing activation function in our tests achieved an F1-score of 0.99 and a mean average precision (mAP) of 100%. Testing on a dataset provided by TCDD Railway Research & Technology Centre (DATEM) confirms the efficacy of our approach, demonstrating a notable decrease in unnecessary work and associated costs.
Analisis Wacana Kritis Representasi Penyalahgunaan Dana APBA Pembangunan Asrama Aceh di Yogyakarta dalam Film “The Contractor”
Authors: Aqif
Published: December 2024

Penelitian ini bertujuan untuk menganalisis representasi isu penyalahgunaan dana APBA (Anggaran Pendapatan dan Belanja Aceh) dalam pembangunan asrama Aceh di Yogyakarta melalui film The Contractor dengan pendekatan analisis wacana kritis. Isu penyalahgunaan dana publik sering menjadi perhatian utama dalam diskusi tentang transparansi dan akuntabilitas pemerintah. Film The Contractor  menggambarkan penyalahgunaan dana dalam pembangunan asrama Aceh, menampilkan cerita yang tidak hanya fiktif tetapi juga merefleksikan realitas sosial dan politik. Dengan menggunakan model analisis wacana kritis Norman Fairclough, penelitian ini memeriksa bagaimana bahasa dan representasi visual digunakan untuk membentuk persepsi penonton, mengungkap ideologi tersembunyi, serta menyoroti dinamika kekuasaan yang terlibat. Melalui tiga dimensi analisis Fairclough - teks, praktik teks, dan praktik sosial budaya - serta intertekstualitas dan interdiskursifitas, penelitian ini mengeksplorasi hubungan antara teks dan konteks sosial budaya yang lebih luas. Hasil analisis menunjukkan bahwa film ini secara efektif mengangkat isu penyalahgunaan dana APBA, mengkritik praktik korupsi, dan menyoroti pentingnya integritas dan akuntabilitas dalam pengelolaan dana publik. Film ini juga memiliki potensi besar untuk mempengaruhi persepsi masyarakat dan mendorong perubahan sosial-politik yang positif. Penelitian ini menegaskan pentingnya media sebagai alat kritis dalam mengungkap ketidakadilan dan mempengaruhi transformasi sosial.
Strategi Komunikasi Pemasaran Digital Akun Media Sosial @virtually.samanthaannisa di Instagram
Authors: Trisnajaya Trisnajaya
Published: December 2024

Jasa virtual assistant merupakan pekerjaan yang muncul akibat adanya digitalisasi. Pekerjaan ini muncul karena adanya permintaan untuk menyediakan asisten secara virtual yang dapat melakukan tugas administratif ataupun teknikal bagi kliennya. Salah satu dari sekian banyak pengguna media sosial yang menyediakan jasa virtual assistant adalah Samantha Annisa dalam akun Instagramnya yaitu @virtually.samanthaannisa. Sebagai pekerjaan yang masih jarang diketahui oleh masyarakat awam, merupakan sebuah tantangan bagi Samantha Annisa untuk mempromosikan jasanya. Melalui media sosial Instagram, Samantha Annisa berupaya untuk melakukan komunikasi pemasaran yang efektif agar audiens yang ditujunya tertarik untuk menggunakan jasanya. Dengan model the circular model of some, penelitian ini bertujuan untuk mengetahui strategi komunikasi pemasaran yang dilakukan oleh @virtually.samanthaannisa dalam beberapa tahap, yaitu share, optimize, manage, dan engage. Penelitian ini menggunakan metode penelitian kualitatif deskriptif untuk memberikan pemahaman yang mendalam mengenai topik dalam penelitian. Hasil penelitian menunjukkan bahwa Samantha Annisa melalui akun Instagramnya @virtually.samanthaannisa mampu untuk memaksimalkan komunikasi pemasaran yang dilakukan berdasarkan elemen dalam the circural model of some oleh Regina Luttrell dengan efektif.
Ekspansi Politik Dinasti Jokowi: Peirce's Semiotic Study on the cover of Tempo Magazine
Authors: Fatiya Zahida  , Nasution Nadya Amalia
Published: December 2024

Media coverage plays a crucial role in shaping public perception of political dynamics in Indonesia, particularly through visual representations. The increasing concerns about political dynasties and their impact on democratic processes have become a significant issue in Indonesian politics.  This research applies Charles Sanders Peirce's semiotic theory to analyze the cover of Tempo magazine using qualitative research. The study aims to reveal the essential messages and ideological constructions conveyed to the audience by examining the signs, symbols, and meanings embedded in the cover design. The analysis focuses on the cover of Tempo magazine's 02 June 2023 edition, "Political Expansion of the Jokowi Dynasty." Through a detailed semiotic study, this research reveals how Tempo magazine utilises visual and textual elements to communicate its editorial stance, attract readers, and reflect contemporary socio-political issues. The results of the study are based on the analysis of Peirce's semiotic theory, namely that Tempo magazine, through the illustrations on its cover, succeeded in conveying a message about the political expansion of the Jokowi dynasty through the use of solid symbols and effective visual signs, including analysis through icons, indexes, and symbols. These results significantly contribute to a deeper understanding of media semiotics and how magazine covers can influence public perception.
Meredesign Pesan Pembangunan Untuk Kesetaraan Gender di Madura (Sebuah Literatur Review)
Authors: Surokim Surokim , Rosyidi Moch. Imron
Published: December 2024

Di Madura khususnya Kabupaten Bangkalan angka buta huruf mencapai angka 76.517 di usia 15 hingga 59 tahun dari jumlah penduduk 1,3 juta. Selain itu memasuki era SDGs madura masih dirumitkan dengan permasalahan budaya Patriarki, seperti adanya upaya Raperda Poligami oleh Pemerintah Kabupaten Pamekasan pada akhir tahun 2016 serta legitimasi kyai mengenai Poligami, bahwa posisi Kyai di masyarakat madura seolah melegalkan poligami. Sehingga poin ke lima dari tujuh belas poin utama SDGs akan sulit tercapai. Di satu sisi masyarakat Madura memiliki kearifan lokal yang sangat unik mengenai kedudukan perempuan. Metode penelitian ini menggunakan studi Pustaka. Maka artkel ini berusaha memberikan solusi bagaimana mengemas pesan pembangunan dengan cara mengetahui karakter audiens. Berdasarkan kearifan lokal tersebut dirasa baik mengkomunikasikan kesetaraan gender dengan pendekatan  ecofeminism. Pembangunan dan inovasi macam apapun tidak akan bermanfaat jika tidak dikomunikasikan. Menurut Childers seorang komunikator pembangunan harus mengetahui audiens, sehingga berangkat dari perspektif itu dirasa perlu merumuskan suatu wacana pembangunan kesetaraan gender dalam bingkai ecofeminism, sehingga dapat memberikan motivasi publik Madura akan pentingnya kesetaraan gender.
Menentang Stereotip Gender dalam Iklan SKINTIFIC x Fimela – International Women’s Day 2024
Authors: Hanifah Nurul , Faturrochman Azis , Dwi Arifianto Budi
Published: December 2024

Penelitian ini bertujuan untuk menganalisis bagaimana iklan "Skintific x Fimela" mendekonstruksi stereotip gender perempuan melalui pendekatan semiotika Roland Barthes. Dengan menganalisis elemen visual, teks narasi, dan simbol-simbol dalam iklan, penelitian ini mengungkap bahwa iklan tersebut menampilkan perempuan sebagai sosok yang kuat, berprestasi, dan mampu melampaui batas-batas tradisional, seperti menjadi atlet bela diri dalam arena internasional. Narasi yang disampaikan tidak hanya mendorong perempuan untuk melampaui stereotip gender, tetapi juga menginspirasi audiens untuk percaya pada kemampuan mereka dalam mencapai impian. Selain itu, konteks perayaan Hari Perempuan Internasional semakin memperkuat pesan kesetaraan gender dan pemberdayaan perempuan yang menjadi inti dari iklan ini. Temuan ini menunjukkan bahwa iklan "Skintific x Fimela" tidak sekadar mempromosikan produk, tetapi juga mengedepankan nilai-nilai sosial yang mencerminkan pemberdayaan perempuan modern yang inspiratif dan mandiri.
A rare case of limb girdle muscular dystrophy with predominant scapulo-humeral involvement: diagnostic challenges and multidisciplinary management in a middle-aged male
Authors: Orchi Proma , Susmita Samiha J. , Eskander Shah M. F. , Zaman Mourin B. , Faruque Farah B. , Luna Shahana A.
Published: December 2024

Limb-girdle muscular dystrophy (LGMD) is a genetically and clinically heterogeneous group of neuromuscular disorders characterized by progressive proximal muscle weakness and varying patterns of scapular winging. Accurate subtype identification is often hindered by diagnostic complexities and limited access to advanced diagnostic tools, particularly in resource-constrained settings. We present the case of a 38-year-old male with a 10-year history of progressive upper limb weakness, scapular winging, and persistent fatigue. Electromyography (EMG) revealed a myopathic pattern, supporting the clinical suspicion of LGMD. Muscle biopsy and genetic testing were not performed due to patient unwillingness and financial limitations. A multidisciplinary management approach comprising low-dose corticosteroids, physiotherapy, and nutritional support led to symptomatic improvement and enhanced functional capabilities. This case underscores the diagnostic challenges posed by the absence of advanced genetic and histopathological investigations and highlights the importance of accessible, patient-centered care. Scapular winging and proximal weakness were pivotal diagnostic features in this case, reflecting the hallmark manifestations of LGMD. The observed improvement with physiotherapy and corticosteroids demonstrates the value of a tailored management strategy in mitigating the impact of this progressive condition. This case emphasizes the need for broader access to diagnostic innovations and advanced therapeutic options to optimize care for patients with rare neuromuscular disorders.
Análise da influência das fibras de aço e poliméricas nas propriedades do estado fresco e endurecido de um Concreto Reforçado com Fibras (CRF)
Authors: Christ Roberto , Pacheco Fernanda , Zamis Ehrenbring Hinoel , Silva dos Santos Jader Willian , Costella Menegussi Giovanna , Fonseca Tutikian Bernardo
Published: December 2024

A adição de fibras ao concreto visa melhorar suas propriedades no estado fresco e endurecido, conferindo o aumento da ductilidade ao compósito. As fibras variam entre o tipo de material, formato, dimensões e propriedades mecânicas. Portanto, tornam-se necessários estudos que analisem os distintos efeitos que estes reforços provocam em concretos reforçados com fibras (CRFs). Assim, este estudo tem como objetivo analisar comparativamente as propriedades no estado fresco e endurecido (aos 7 e 28 dias) de concreto com fibras de aço (CRFA) e poliméricas (CRFP). Os reforços possuem fator de forma de 33 e teor fixo de adição de 2,00%. No estado fresco, percebeu-se que as fibras impactaram consideravelmente na trabalhabilidade do compósito. Já no estado endurecido, os resultados do CRFA de resistência à compressão, módulo de elasticidade e resistência à tração na flexão foram superiores aos do concreto convencional (CC), e o CRFP foi inferior. O fator de tenacidade para ambos CRFs foi superior ao CC. Os resultados encontrados evidenciaram que o material da fibra interfere no desempenho mecânico do CRF.
Integração da Modelagem da Informação e SIG em aplicações de mobilidade e transportes
Authors: Olivatto Tatiane Ferreira , Borchers Tatiane , Lima Bruno Joaquim , Bueno Cristiane
Published: December 2024

O estudo analisa a integração de Modelagem de Informação (BIM ou CIM) e Sistemas de Informação Geográfica (SIG) em projetos de mobilidade e transporte através de análise bibliométrica e revisão sistemática. Dez artigos entre 2018 e 2021 foram identificados, abordando temas como gestão do tráfego, logística e infraestrutura viária. Pouca colaboração entre autores foi observada, assim como ausência de acoplamento bibliográfico e cocitações, resultando linhas de pesquisas discrepantes. A metodologia predominante trata da proposta de criação de um modelo, utilizando os softwares ArcEngine, Navisworks, Revit e Civil3D. A avaliação de palavras-chave frequentes revelou o termo CGB (CAD, GIS e BIM) e RIM (BIM em projetos de estradas). Algumas limitações incluem a necessidade de ajustes manuais nos processos de integração e restrição de aplicação dependendo do escopo do trabalho. Futuras pesquisas devem focar na integração de bases e melhoria na obtenção e tratamento de dados para melhorar a estruturação dos modelos.
Efeito da saturação do agregado graúdo reciclado na resistência mecânica e durabilidade do concreto
Authors: Jordani Bárbara , Ribeiro Francisco Roger Carneiro , Oliveira Valéria Costa de , Pierozan Rodrigo Cesar
Published: December 2024

A incorporação de resíduos de concreto na produção de novos concretos revela-se como uma abordagem sustentável na construção civil. No entanto, é essencial o estudo das propriedades mecânicas e de durabilidade do concreto produzido com este resíduo, garantindo a segurança das edificações. Este trabalho investiga o comportamento mecânico, a resistividade elétrica e a absorção de água por capilaridade em concretos convencionais, sob diferentes relações água/aglomerante, produzidos com agregados graúdos reciclados de concreto (AGRC) secos e úmidos, curados em condições de baixa e alta umidade relativa. O teor de agregado graúdo reciclado foi determinado por compensação de massa. A resistência à compressão axial e a resistividade elétrica foram analisadas aos 28, 91 e 112 dias, enquanto a absorção de água por capilaridade foi avaliada apenas aos 28 dias. Os resultados apontam que a presença de AGRC não influencia significativamente a resistividade elétrica. Quanto ao comportamento mecânico, a relação a/c de 0,31 apresentou os melhores resultados, independente do tipo de agregado. Em relação à condição de cura, verificou-se que a cura a 60% de umidade relativa resultou em valores maiores de resistividade comparados à cura saturada, com efeito inverso na resistência à compressão. Além disso, observou-se que a inserção de AGRC nas condições de cura estudadas não indica risco à corrosão das armaduras. Portanto, este estudo contribui para a viabilidade do uso de agregados reciclados na produção de concretos sustentáveis, sem comprometer a durabilidade e a integridade estrutural das edificações.
HEMEROBIA E A SUA INFLUÊNCIA NA QUALIDADE DA ÁGUA EM BACIA DE REGIÃO METROPOLITANA: SUBSÍDIOS PARA A GESTÃO DA ÁGUA
Authors: Silva Fabio Leandro da , Menezes Denise Balestrero , Vanzo Gabriel
Published: December 2024

As regiões metropolitanas são marcadas por apresentarem um grande contingente populacional e forte ocupação de suas paisagens. Devido ao desenvolvimento das atividades antropogênicas, a qualidade da água e a naturalidade da paisagem acabam sendo alteradas por causa do comprometimento da capacidade de autorregulação. Deste modo, estudos que avaliem estes impactos auxiliam na promoção da gestão ambiental e na manutenção dos serviços ecossistêmicos em áreas urbanizadas. Este estudo buscou utilizar indicadores de qualidade da água (Índice de Qualidade da Água e o Índice de Estado Trófico) e a hemerobia (naturalidade) para verificar o gradiente do rio Sorocaba, no Estado de São Paulo. Os resultados demonstram o predomínio de áreas antropogênicas (> 60%), principalmente ligadas ao agronegócio (i.e. área descoberta, lavoura temporária, silvicultura e pastagem) e regiões urbanizadas, além das áreas hemerobióticas (com dependência tecnológica e antropogênica, bem como capacidade de autorregulação comprometida). A qualidade da água oscila entre boa e regular e o grau de trofia predominante no rio Sorocaba é hipertrófico, apresentando variações de acordo com a estação climática (chuvosa e seca) e o gradiente do corpo hídrico. Para a continuidade da provisão de serviços ecossistêmicos e melhoria da complexidade da paisagem, recomenda-se a recuperação da vegetação nativa e o tratamento de efluentes domésticos e industriais.
Multiple Sayings as a Resource for Halting a Course of Action in Interaction: Evidence from Turkish Everyday Discourse
Authors: Aydın Derya , Ercan Gülsüm Songül
Published: December 2024

Self-repetition, which is defined as repeating one’s own utterance, performs various functions in spoken discourse. This study investigates the use of “multiple sayings”, a specific type of self-repetition which involves the speaker’s repetition of some unit of talk in the same turn multiple times, under a single intonational contour. In everyday discourse different linguistic resources are used as multiple sayings performing different communicative functions. The study limits itself in two aspects: (i) the use of lexical multiple sayings such as “yes yes yes” and “wait wait wait”; (ii) their function of halting the prevailing course of action in talk-in interaction. Although repetitions have been investigated in Turkish in several studies, this specific form of repetition and this specific function remains to be explored. To this end, using Conversation Analysis as the method of analysis, the study aims to find out what multiple sayings are used in Turkish everyday discourse for halting a course of action and what courses of action they halt. The database of the study consists of the recordings of a 10-hour Turkish everyday discourse. The analysis of the data reveals that in line with the previous studies conducted in other languages, Turkish speakers use multiple sayings to stop an unwarranted course of action, which implicates the universality of this function.
Relationship between Bilingual Experience and Cognitive Control of Bilingual Children
Authors: Gong Xiaowei , Aktan-erciyes Asli , Karadöller Dilay Z.
Published: December 2024

There has been growing interest in how different dimensions of bilingual experience relate to cognitive abilities within the bilingual group. However, this interest rarely targeted data from young bilingual children who lack sufficient language production. The current study includes a variety of bilingual experience-related factors, such as language proficiency, language use, and code-switching frequency, to investigate 30- to 48-month-old bilingual children as well as their parents. Results showed that children’s age, rather than any of the bilingual-experience-related variables from neither children nor parents, predicted children’s cognitive control abilities. This study is one of the few that looked at the bilingual effects by including three bilingual-experience-related dimensions as well as parental factors. The implications of applying the bilingual experience dimension-based approach and including environmental factors while studying young bilingual age groups with limited language production were discussed.
AFET YÖNETİMİNDE İTFAİYENİN ROLÜ: KUMLUCA (ANTALYA) SELİ ÖRNEĞİ
Authors: Savaç Neslihan , Genç Fatma Neval
Published: December 2024

Bu çalışmada sel taşkınlarında itfaiyenin rolü incelenmektedir. Bu amaçla 2022 yılında Antalya’nın Kumluca İlçesinde meydana gelen sele müdahalede rol alan 80 itfaiye personelinin % 10’u ile yarı yapılandırılmış görüşme metoduyla veri toplanmıştır. Çalışmada elde edilen sonuçlar şöyledir; İtfaiyeciler, Kumluca seline müdahalede koordinasyon yanında afet sonrasında hasar tespiti, raporlama aşamalarında da görev yapmışlardır. Müdahale sürecinde itfaiyeciler yolların zarar görmesi nedeniyle kazalar yaşamış, fiziki engellerle karşılaşmıştır. Görüşmelerden afetlerin öncesinde risk analizi ve azaltımının, hazırlığın, koordinasyonun, farklı afet türlerinde uygun araç-gereç ve teknolojiye sahip olmanın, iş birliğinin, ortak tatbikatların, halkın afete yol açabilecek tehlikeler ve riskler hakkında bilgilendirilmesinin, halk eğitim faaliyetlerinin, halkın ve sivil toplumun sürece dahil edilmesinin, gönüllü itfaiyeciliğin önemi anlaşılmaktadır. Özellikle afetler olmadan önce kurumların araç-gereç, malzeme envanterinin güncel olarak tutulması, bu bilgilerin muhtarlıklarda da olması ve bilgilerin ilgili diğer kurumlarla paylaşılmasının önemi anlaşılmıştır.
Очерки истории физико-математического образования в Саратовском университете
Authors:   Саратовский государственный университет, Аникин В. М.
Published: December 2024

Шестой выпуск «Очерков» выходит в год 115-летия основания Саратовского университета. Книга открывается биографией С. А. Богуславского (1883–1923), одного из первых профессоров СГУ, выдающегося физика-теоретика первой четверти XX века. Герой второго очерка – профессор Г. П. Боев (1898–1959) – запечатлен на одной фотографии с С. А. Богуславским 1921 г. как первый выпускник физико-математического факультета СГУ, впоследствии несколько десятилетий плодотворно проработавший в университете. Очерк «15 августа 1928 г. в истории Саратовского университета» содержит дополнительные документальные данные о событиях, связанных с проведением в Саратове VI съезда Российской ассоциации физиков. Три очерка посвящены истории становления и развития крупных структурных подразделений СГУ – Вычислительного центра, факультета нано- и биомедицинских технологий и Балашовского института СГУ. Включены материалы о профессоре Е. С. Петровой (1937–2009), первом докторе педагогических наук СГУ в области преподавания математики. Статистика и описание методического обеспечения работы диссертационного совета по физико-математическим наукам на базе СГУ в 1991–2021 гг. составляют содержание заключительного очерка.

Для преподавателей, аспирантов и студентов университетов.
Modern approaches to teaching the Ukrainian language as a foreign language
Authors: Pavlenko Oksana
Published: December 2024

Modern approaches to teaching the Ukrainian language as a foreign language (Shevchuk, Yuri I. (2022). Beginner’s Ukrainian: with interactive online workbook. Third integrated edition. New York: Hippocrene Books, Inc.)
La dirección pública de los centros de gobierno ¿asesoramiento o copresidencia? El jefe de gabinete de la Casa Blanca como estudio de caso (1946-2024)
Authors: Casal Oubiña Daniel
Published: December 2024

El presente artículo se centra en la figura del Jefe de Gabinete de la Presidencia de los Estados Unidos como una élite político-administrativa del sistema institucional. El estudio tiene como principal pregunta de investigación conocer el proceso de reclutamiento de las personas que han ocupado el cargo entre 1946-2024. Para ello construye una base de datos con los perfiles de los 31 responsables del centro de gobierno de los Estados Unidos analizando que en su reclutamiento influyen factores territoriales vinculados al origen de los presidentes, elementos de formación educativa y características de experiencia profesional, constatando que el cargo no es atractivo para personas con una carrera política dilatada y que al mismo tiempo tampoco es un puesto que impulse carreras políticas posteriores debido a su alta rotación.
Fecha de recepción: 11.07.2024Fecha de aprobación: 22.10.2024
Derecho fundamental al amor en Colombia: un compromiso constitucional retórico con limitada materialización práctica
Authors: Perilla Granados Juan Sebastián Alejandro
Published: December 2024

La Constitución Política colombiana de 1991 transforma el panorama jurídico existente hasta ese momento, dado que acoge un Estado Social de Derecho que clasifica a los derechos humanos en diferentes generaciones. La primera de esas generaciones corresponde a los derechos fundamentales, los cuales tienen la posibilidad de ser exigidos de manera inmediata a manera de mínimos necesarios para la subsistencia de cualquier persona. Así, y como una innovación disruptiva, esta norma superior consagra al amor como un derecho fundamental para los niños y las niñas. Sin embargo, su carácter indeterminado impide una materialización plena a través de acciones constitucionales, pues no es posible obligar a alguien a amar a otra persona. En consecuencia, en este artículo se delimita el alcance iusteórico de este derecho como un principio y valor constitucional, que solo podrá ser materializado a través de otros derechos según cada una de las realidades desde y para las cuales sea aplicable.
Fecha de recepción: 04.08.2024Fecha de aprobación: 25.10.2024
Altitudinal Variation of Mineral Elements in Common Plant Species, and Soils of Erzincan Province-Ergan Mountain
Authors: Osma Etem , Varol Tuğçe , Kıymaz Muhammet Onur , Türkoğlu Halil İbrahim , Yıldız Faruk , Kandemir Ali , Elverici Mert , Kılıç Engin , Hasbenli Abdullah
Published: December 2024

This study was conducted with 30 common plant species growing at different altitudes (1500 m, 2000 m, 2500 m and 3000 m) of Mount Ergan in the province of Erzincan. The concentration of mineral elements was determined in the collected plants and the soils in which they grew at 1500 m of altitude (Alcea calvertii (Boiss) Boiss., Glaucium leiocarpum Boiss., Astragalus ornithopodioides Lam., Genista aucheri Boiss., Linum mucronatum Bertol, Anchusa leptophylla Roem. & Schult, Euphorbia virgata Waldst. & Kit.), at 2000 m (Tanacetum mucroniferum Hub. Mor. Et Grierson, Hypericum scabrum L. Inula oculus-christi L., Barbarea auriculata Hausskn. ex Bornm, Onobrychis cornuta L., Desv., Globularia trichosantha Fisch. & C.A.Mey, Genista aucheri Boiss., Euphorbia virgata Waldst. & Kit.), at 2500 m (Scutellaria orientalis L., Lallemantia canescens (L.) Fisch. & Mey., Coronilla orientalis Miller, Dianthus orientalis Adams., Crepis armena DC., Campanula tridentata Schreber, Euphorbia petrophila C.A. Meyer, Anthemis cretica L., Papaver fugax Poiret, Aster alpinus L.) and at 3000 m (Pedicularis comosa L., Astragalus nezaketiae A.Duran & Aytaç, Scorzonera sericea DC., Campanula tridentata Schreber, Anthemis cretica L., Papaver fugax Poiret, Hedysarum erythroleucum Boiss., Senecio hypoleucus Benth). Different parts of the collected plants (flowers, leaves and roots) and the soils in which they grew were pre-treated in the laboratory. The element concentrations of the prepared samples were analyzed by ICP-MS. The obtained metal data of plants and soils were statistically evaluated, and significant differences were found between the altitudes. It was determined that elevation significantly affected the mineral element distribution in both plants and soil. It was observed that the elements generally decreased in the soil as the elevation increased. In addition, it was noticed that plants with blue purple flower were dominant in the upper part of the mountain and plants with yellow flower were dominant in the lower part of the mountain.
Sera Sebze Üreticilerinin Topraksız Teknikleri Kullanma Eğilimini Etkileyen Faktörlerin Analizi: İzmir’in Menderes İlçesi Örneği
Authors: Özgür Mustafa , Engindeniz Sait , Öztürk Görkem
Published: December 2024

Bu araştırmanın temel amacı, İzmir’in Menderes ilçesinde serada sebze üretimi yapan üreticilerin topraksız teknikleri kullanma eğilimini etkileyen faktörleri analiz etmektir. Araştırmada veriler oransal örnekleme yöntemi kullanılarak belirlenen 94 üreticiden yüz yüze anketler yapılarak elde edilmiştir. Araştırmada ilk olarak üreticilerin sosyo-ekonomik özellikleri incelenmiş, ardından üreticilerin topraklı koşullarda geleneksel yöntemlerle hıyar üretiminin teknik ve ekonomik yönleri analiz edilmiştir. Üreticilerin serada topraksız tekniklerle sebze üretme eğilimini etkileyen faktörlerin analizinde lojistik regresyon (logit) modellerinden yararlanılmıştır. Araştırma sonuçlarına göre, üreticilerin yaşı ortalama 46,94, eğitim süresi ise ortalama 9,30 yıl olarak belirlenmiştir. Üreticilerin seracılık deneyimi ortalama 16,28 yıldır. İşletmelerde ortalama sera alanı 5,78 dekar, ortalama sera sayısı ise 5,40’dır. Lojistik regresyon modeline göre etkili ve istatistiksel olarak anlamlı bulunan değişkenler üretici yaşı ve üreticinin topraksız tekniklerle ilgili bilgi düzeyi olarak belirlenmiştir. Üretici yaşı arttıkça topraksız teknikleri kullanma eğilimi 1,032 kat azalmaktadır. Topraksız tekniklerle ilgili bilgisi olmayan üreticilerin bu teknikleri kullanma eğilimi 4,651 kat azalmaktadır. Dolayısıyla, üreticilere topraksız tarım tekniklerinin avantajları ile uygulama yöntemleri hakkında bilgi verilmesi gerekmektedir. Ayrıca, topraksız tarım yöntemlerinde gerekli olan sistemler ve otomasyonun kurulum maliyetlerinin yüksek olması nedeniyle, üreticilere bu konuda destek ve teşvikler de sağlanmalıdır.
Diagnostic performance of ultrasound versus 99mTc-sestamibi scintigraphy in preoperative depiction and localization of parathyroid adenoma in patients with primary hyperparathyroidism
Authors: Gürlüler Ercüment
Published: December 2024

Objectives: To evaluate diagnostic performance of ultrasound (US) and 99mTc-sestamibi scintigraphy (MIBI) in preoperative depiction and localization of parathyroid adenoma in patients with primary hyperparathyroidism (PHPT)
Methods: A total of 645 patients (mean age: 52.3 [range; 18-81] years, 72.9% were females) who underwent parathyroidectomy for PHPT due to histopathologically-confirmed adenoma were included in this retrospective cohort study. The accuracy of preoperative US and MIBI in the depiction and localization of parathyroid adenomas was evaluated with respect to intraoperative localization.
Results: Preoperative MIBI was more accurate than preoperative US in identifying upper right (6.2% vs. 2.6%) and upper left (7.5% vs. 3.8%) orthotopic adenomas, and ectopic adenomas (1.5% vs. 0.7%). Failure to identify an adenoma was less commonly noted on preoperative MIBI than on preoperative US (26.9% vs. 32.8%). The US mainly failed to diagnose the adenomas located in the upper left (27.4%), lower left (25.9%) and upper right (19.3%) orthotopic sites, while MIBI mainly missed those located in the lower left (36.2%), lower right (24.7%) and upper left (20.1%) orthotopic sites. True-positive depiction rates on the preoperative US (60.4% for ≤250 mg, 80.3% for ≥901 mg) and MIBI (56.7% for ≤250 mg, 86.7% for ≥901 mg) were increased as the parathyroid weight increased.
Conclusions: Our findings indicate inconclusive results in the identification of parathyroid adenoma in nearly one-third of cases with both US and MIBI and the side-specific and site-specific variations in their performance. Hence, the combined use of these imaging modalities may be of great clinical value in the precise preoperative depiction and localization of parathyroid adenomas.