bluuebunny/crossref_metadata_2025 huggingface dataset:
Creating Reading Comprehension Computer Based Test (CBT) as The Graduation Requirement of Vocational College Students
Authors: Saputri Lenggahing , Ratna Maharani , Puspitasari Nadia
Published: November 2023

Vocational College of Diponegoro University required the students to have a specific English test as their graduation requirement. This study aims to create the English test in the form of CBT for Vocational College students as their graduation requirement. One of the test components is reading comprehension test. This reading comprehension test consist of 5 passages which include 9 questions in every passages. The passages consist of business email, inquiry email, newsletter, complain letter, response to complain letter, resignation letter, job vacancy, promotional poster for events, promotional materials, regulation, job contract, company rules, and work ethic. The question in each passages include identifying main idea, objective, explicit information, implicit information, reference, word meaning based on context and cohesive device. The method used in this study is research and development method using ADDIE (Analysis, Design, Development, Implementation, and Evaluation) model as the research procedures. The result of this study is the reading comprehension computer-based test (CBT) system which consists of 5 different functional pages namely the student login page, student question page, package upload, passage and question upload and student result page.
A Review on Internet of Medical Things (IoMT): A Case Study for Preeclampsia
Authors: Hadiyanto Hadiyanto , Sukamto Sukamto , Suryono Suryono , Kurnianingsih Kurnianingsih
Published: November 2023

Preeclampsia detection research has started exploring some methods to diagnose and predict preeclampsia. Machine learning (ML) methods and the Internet of Things (IoT) have been successfully implemented in medical research to improve the diagnosis and prevention of complex diseases and syndromes. The goal of this work is to undertake a review of the most recent work on preeclampsia detection. The research focused on articles related to the keywords 'machine learning, 'Internet of Things, 'IoT', 'medical', and preeclampsia in five main databases, namely IEEEXplore, ScienceDirect, SpringerLink, ResearchGate, and ACM Digital Library, etc. We selected and reviewed 90 articles in the end. The final discussion highlights research gaps that remain to be investigated in the cognitive approach to IoT. The study found that preeclampsia detection based on the internet of Medical things (IoMT) was not found, so it became a big opportunity to develop this research in the future.
Master Data Management using Record Linkage Toolkit for Integrating Lecturer Master Data
Authors: Amin M. Miftakul , Sutrisman Adi , Dwitayanti Yevi
Published: November 2023

Merging databases from different data sources is one of the important tasks in the data integration process. This study will integrate lecturer data from data sources in the application of academic information systems and research information systems at the Sriwijaya State Polytechnic. This integration of lecturer data will later be used as a single data as master data that can be used by other applications. Lecturer data in the academic section contains 444 records, while those from the p3m section contain 443 records. An important task in the database merging process is to eliminate duplicate records. One of the important libraries in the formation of this master data management uses the record linkage toolkit which is implemented in the python programming language. The steps taken are pre-processing, generating candidate record pairs, compare pairs, score pairs, and finally the data link to merge the two data sources. In this study, 5 fields, namely username, name, place of birth, date of birth, and gender, from each data source were used to measure the level of record similarity. The result of this research is the formation of lecturer master data from the merging of the two sources.
Assessment of Environmental Health Risks Associated with Chemical Content of Drinking Water for Workers in the Copper and Gold Mineral Ore Processing Industry
Authors: Susanto Arif , Zannah Miftahul , Putro K. , Manuel Anthony A. , Yochu Wiliam E. , Mahlisa Rizky
Published: November 2023

Drinking water is a necessity for all living organisms and should be of good quality and free from hazardous contaminants. Chemical agents such as nitrate, nitrite, selenium, chromium, cadmium, manganese, cyanide, and fluoride can contaminate drinking water. Therefore, this study aims to analyze the health risks associated with these chemical agents and their potentially harmful effects on workers. The Environmental Health Risk Analysis (EHRA) method was used to evaluate the chemical agents present in the Concentrating Division area of PT Freeport Indonesia (PTFI). It was discovered that the average concentration values of all chemical agents were below the Environmental Health Quality Standards (EHQS) established in the Minister of Health Regulation Number 2 of 2023. The risk quotient (RQ) results, obtained through the division of intake and reference dose (RfD), were less than 1 (RQ<1), indicating that chemicals constituting the drinking water found in the Concentrating Division area did not pose health risks to workers. Risk management and communication efforts in the area are unnecessary because the detected chemical agents are considered safe. However, daily supervision of potentially hazardous chemical agents is still necessary.
Data Analysis of Indoor Air Quality with and without HEPA Filter in Air Purifier (Study Case: East Jakarta Residential Area)
Authors: Bhakti Muhammad Agni Catur , Endah Lestari Tika , Wandy Wandy
Published: November 2023

Humans in good health breathe air containing 21% oxygen 12 times per minute at rest. The number of breaths increases as people engage in activities. Humans need clean air to live. Therefore, measuring indoor and outdoor air quality is essential for a better lifestyle. Some circumstances and causes may impact the outcome in fine particulate matter PM2.5. Air purifiers and filtration systems were needed to be tested in East Jakarta, Indonesia, to improve indoor air quality. Different filter types are used to categorize air purifiers. HEPA filters have been created and enhanced as part of continual efforts to preserve clean, breathable air. Air purifiers decrease particulate matter with HEPA filters. This study aimed to determine how an air purifier's HEPA filter impacts air quality in a residential area of East Jakarta, Indonesia. This research contributes to a solution whether to use or not to use air purifiers indoors to have better air quality. The air quality in the East Jakarta residential area during the research period was shown to be directly improved from 8.88 to 10.49 mg/m3 with standard deviations of 9.01 to 10.18 mg/m3 for particulate matters when an indoor air purifier with a HEPA filter turned on in seven days.
The practice of disclosing carbon emissions in developing countries: Evidence from indonesia
Authors: Wahyuningrum Indah Fajarini Sri , Hidayah Retnoningrum , Ihlashul’amal Muhammad , Sriningsih Sriningsih , Setyadharma Andryan
Published: November 2023

This study seeks to analyze the practice of disclosing carbon emissions by public companies in Indonesia. It also explores what determinants influence these emissions. The determinants that have been tested are institutional ownership, board diversity, profitability, leverage, and environmental performance. This study uses a sample of 35 public companies in non-financial sectors that were listed on the Indonesia Stock Exchange during the period 2017-2021. The collected data were analyzed using descriptive statistical analysis and multiple linear regression analysis. The results show that disclosure of carbon emissions in Indonesia still tends to be low. The factors found to influence this disclosure are environmental performance which has a positive effect and institutional ownership has a negative effect. Meanwhile, other variables such as the diversity of board nationalities, profitability, and leverage have no effect on the disclosure of carbon emissions.
From Extraction to Attraction: Understanding the Socio-Economic and Environmental Interplay of Tin Mining and Tourism
Authors: Kusumah Echo Perdana , Ibrahim Ibrahim , Wahyudin Nanang , Utami Eva
Published: November 2023

The objective of this study is to gain a thorough understanding of the dynamic relationship between the tin mining industry and tourism in the Bangka Belitung Province of Indonesia. This study utilizes qualitative research methods. Findings revealed that there are challenges associated with the relationship between tin mining and tourism in the Province. The process of transitioning from extraction to attraction necessitates meticulous planning and collaboration among different stakeholders, such as local communities, government entities, private enterprises, and non-governmental organizations. Ensuring the long-term sustainability of both industries requires a paramount focus on balancing economic interests with environmental protection. This study highlights the importance of adopting a comprehensive approach to sustainable development in the Bangka Belitung Province. It is crucial for policymakers to give utmost importance to responsible mining practices and implement strict environmental regulations. At the same time, they should also focus on promoting investment in tourism infrastructure and enhancing capacity building. The collaboration between the mining and tourism sectors has the potential to generate innovative solutions that can bring benefits to the local economy, while also preserving cultural heritage and safeguarding the environment.
Estimation Potential Of Methana Gas From Puwatu Municipal Solid Waste Landfill, Indonesia
Authors: Sumarlin Sumarlin , Purwanto Purwanto , Syafrudin Syafrudin
Published: November 2023

Methane gas produced from municipal solid waste landfill has excellent energy potential if managed with the right technology. This study aims to estimate the amount of methane emissions from Puuwatu landfill in Kota Kendari, Indonesia using LandGEM V303 software. The LandGEM model used is based input data on the year landfill was opened and received waste, the year landfill was closed, and the potential for methane production. Total methane production in 2011 reached 8.3 × 102 (Mg/year), the first year after receipt of waste by landfill while the maximum methane production rate occurred during 2027, indicating a production peak of 1.44 × 104 (Mg/year). The results of this study can be used for the design and operation of methane collection and control of greenhouse gas emissions.
Risk Factors for Physical Conditions in the Home Environment and Numbers of Bacteria with Toddlers Pneumonia Incidence
Authors: Bahri Bahri , Raharjo Mursid , Suhartono Suhartono
Published: November 2023

Pneumonia caused the deaths of 808,694 children under the age of 5 years, 15% of all deaths toddlers in the world and 277 deaths aged 29 days-11 months in Indonesia. Pneumonia is the most common cause of death for toddlers compared to other diseases, more than the combined Acquired Immune Deficiency Syndrome (AIDS), malaria and measles. This purpose of study to determine the risk factors for the physical environment of a toddlers house and the numbers of bacteria in the incidence of pneumonia cases. The study was conducted using a case control approach with a sample size of 130 and a ratio of 1:1. The results of the analysis showed physical quality in the form of housing density variables (p value= 0.005), type of house floor (p value= 0.013), light intensity (p value= 0.035), humidity (p value= 0.030) and numbers of bacteria (p value= 0.002) who do not meet the requirements are a risk factor for the incidence of pneumonia cases in toddlers. however, the numbers of bacteria cannot be used as a risk factor due to limited validity in data sampling which did not conduct research on the types of bacteria in the sample.
Effects of Using Sawdust Ash as a Stabilizer for Expansive Soils
Authors: Bosco Niyomukiza John , Yasir Yusuf
Published: November 2023

Expansive soils are known to swell and shrink with moisture content changes, rendering them unsuitable for construction without proper stabilization. Cement and lime have conventionally served as common additives for soil stabilization. However, in Uganda, the escalating costs of these additives accentuate the need for alternative solutions. Therefore, this research attempts to investigate the viability of sawdust ash, an affordable agricultural waste, as an effective stabilizer for expansive soils. Through systematic experimentation, various percentages of sawdust ash (ranging from 0% to 10%) were introduced into the soil matrix. The objectives of the study were achieved through a series of laboratory tests, including gradation analysis, Atterberg limit determination, compaction, and California Bearing Ratio (CBR) test. The findings revealed the soil is clay with high plasticity, emphasizing the need for stabilization. Importantly, the addition of sawdust ash resulted in a substantial reduction in the plasticity index, from 35% to 16%, at 0% and 10% sawdust ash content, respectively. Furthermore, the incorporation of sawdust ash led to an increase in the maximum dry density and a reduction in the optimum moisture content as its proportion was augmented. Notably, with 6% sawdust ash content, the CBR value reached its highest point at 14.4%. These outcomes reveal the potential of sawdust ash as an economically attractive alternative to traditional stabilizers such as cement and lime. This research contributes valuable insights to the field of soil stabilization and offers a sustainable solution that addresses both economic and environmental concerns in construction practices.
A Preliminary Review of Poly(lactic acid)-based Biodegradable Foam and its Techno-economic Model
Authors: Yudanto Yusuf Arya , Opaprakasit Pakorn
Published: November 2023

Biodegradable polymers using renewable resources with properties that are comparable to bio-based and fossil-based polymer materials at a comparable cost have been studied and developed in an effort to solve environmental issues, especially expanded polystyrene. One potential raw main material to replace EPS is poly(lactic acid), a synthetic polymer made from lactic acid, which is made by fermenting organic materials like sweetcorn, rice, soya, potatoes, or whey. It is used in food and non-food packaging, drug-controlled release, agriculture, automotive, and electronic accessories. Foaming is vital in developing lighter, more cost-effective materials that may be utilized for a range of purposes due to their general features, such as lightweight, good heat, more ductile (elastic), and excellent energy absorption (impact resistance). In this review, different types of foaming processes and their process parameters are focused at. It was written following the procedures outlined in the PRISMA2020 (Preferred Reporting Items for Systematic Reviews and Meta-Analysis) guidelines for conducting a review to reports and evaluating a wide variety of interventions. Furthermore, a sustainable material should focus on the efficacy of its resource consumption and the economic feasibility of the product it creates. An economic feasibility study is also provided in this article aims to evaluate how much profit a production plant can make. The techno-economic model developed in this study yielded a profit on sales of 69.69% and an internal rate of return of 44.0%. Techno-economic modeling favored the commercial use of poly(lactic acid)-based biodegradable foam based on its positive net present value, short payback period, and high internal rate of return.
The Impact of Policy Implementation on The Use of Solar Power Plants at dr.Asmir Army Hospital
Authors: Yoesgiantoro Donny , Nurbaiti
Published: November 2023

Every aspect of human life is being impacted by the coronavirus disease 2019 (COVID-19) pandemic. The efforts to stop the virus's spread and the halt of economic activity have a big impact on the environment. The same thing also had an effect on the operational facilities of the Indonesian army, one of which was a hospital. During the pandemic, the need for electricity to serve patients, especially patients who were exposed to Covid-19 in military hospitals, increased sharply so that a large amount of energy was needed to support the operations of army hospitals. This research was conducted at dr. Asmir Army Hospital Salatiga. The research was carried out by means of literature review and direct observation to the hospital. The results of the study found that during a pandemic at the dr.asmir army hospital, Salatiga, electricity needs were supported by new, renewable energy, namely solar power plants with the currently available capacity of 14,400 Watts. Initially the solar power plant was used for the needs of the oxygen generator, but because the available capacity was still small, the electricity grid was used to save on hospital electricity costs.
Systematic Review: Quality and Cost Control of The Back-Referral Program National Health Insurance in Diabetes Mellitus Patients Type 2
Authors: Permatasari Putri , Nadjib Mardiati
Published: November 2023

Studies show that there are still deficiencies in the level of quality control and the cost of the referral programme in pharmacies, first-level health facilities, advanced referral health facilities, and the Social Security Administration of Health itself. This situation will affect services provided to patients through the referral program. This study was conducted to determine the factors that influence quality control and the cost of the back referral programme (DRR). Literature review studies were conducted on 11 national journals and six international journals, which were uploaded online in the 2016–2021 period. The keywords used are quality control and the cost of the BPJS-K (social security agency of health) Back Referral Program (PRB), which are man (human resources), material-machine (facilities and infrastructure), method (method), market (environment), money (financial), and time. (time). Patients with chronic diseases, in particular those who have diabetes mellitus, take up time that affects BPJS Health's quality assurance and referral programme expenditures. Due to closer proximity and quicker service, PRB allows JKN participants to travel less and wait less. A programme called PRB has the ability to offer BPJS Health participants a wide range of advantages as well as chances for BPJS Health to deliver efficient and effective healthcare.
Regression-based Model Deciphers Progression on Health Management for Two Long-standing and Unresolved Infectious Diseases in Indonesia: Integration of Outpatient Data by the National Universal Health Care (BPJS) and Fluctuation of Registered HIV and Malaria Cases
Authors: Hidayat Alam A. , Nurlaila Ika
Published: November 2023

Although the COVID-19 outbreak was recently declared overcome COVID-19 is not the sole life-threatening infectious disease for which we direct our all resources. HIV and malaria are, on the other hand, two long-standing national health issues that are yet to find a proper solution. We query how these two infectious diseases load volume on National Burden as represented by the claims National Health Resilience and how far our efforts paid thus far affect the progression on optimally putting the cases in a break. We approach these mathematically as we hardly found integrated reports on this matter. Hence, we employed regression linear to model the Health Resilience of Indonesia based on the dynamics of outpatients and inpatients across facility categories (class) provided by National Universal Health Care (BPJS) in the context of HIV and malaria infection cases respectively. The estimation of the two regression parameters was done via the ordinary least square (OLS) method. We used pandas 1.3.5 for performing the data analysis, seaborn 0.11.2 and matplotlib 3.5.1 for the data visualization, and scipy 1.7.3 and statmats 0.31.2 for the statistical analysis. Our results show that the number of outpatients declines as the number of HIV and malaria cases increase. Furthermore, we obtained significant associations between the increased HIV rate and decreased number of outpatients in class 2 (P=0.030), class 3 (P=0.002), and the total outpatients (P=0.0019). These patterns are not observed for malaria cases. Meanwhile, the increase in HIV cases was found to be associated with the decreased number of registered BPJS in class 1 (P=4e-4), class 3 (P=1.5e-6), and total participants in all classes (P=3.6e-6). Less strong associations were found between the malaria cases with decreased number of participants in BPJS class 1 (P=0.010), class 3 (P=0.042), and the total registered to BPJS (P=0.045). Our data suggest that the higher the HIV incidence rate the lesser likelihood of the affected patients being treated as outpatients using facility classes 2 and 3 since this may lose the transmission control intervention. Intriguingly, in the sense of the BPJS facility category where an increased HIV rate is seen to be strongly associated with a decreased registration number for class 1 and class 3, the monthly dues and the adequateness of expected facility items may be the most abductive reasoning. Despite our understanding that these require validation cohort, taken altogether our data hint the threat of HIV is steady and demands a new approach to strategizing for the sake of limiting the transmission as well as maintaining the quality of life of the affected patients.
Phenomenological Study of Knowledge, Public Perception in Kendal During The Pandemic and The Implementation of A New Normal in 2020
Authors: Sutiningsih Dwi , Kristiawan  , Syahroni Arfan , Hasanah Uswatun , Nurvita Silvia
Published: November 2023

COVID-19 is a disease that has infected people in more than 190 countries in a period of 3 months and has infected more than 8,745,570 confirmed cases in the world. The Indonesian government applies a new normal life health protocol to prevent transmission of COVID-19. Objective: to find out and explore deeply how the level of knowledge, public perception to face Pandemic and preparation in implementing the new normal. Method: This research is a qualitative research with a descriptive phenomenological approach. The population in this study is a representation of Kendal, Jetak Village, Getasan District, Semarang Regency, Central Java. Results : There are six types of occupations, namely: farmers, teachers, factory workers, traders, drivers, and casual daily construction workers; most of the respondents or 90 % did not know the cause and mode of transmission of COVID-19 correctly; the respondent does not understand the terms People Under Surveillance, Patients Under Surveillance and People Without Symptoms; All respondents always update information about COVID-19 due to fear of being infected; COVID-19 disease cannot be controlled because of community disobedience; This outbreak has affected their income; All respondents were aware of various policies in disease management; The community has carried out various prevention activities; 90 % of respondents lack understanding about the concept of new life; The economic issue and following the rules of a normal life ia a new challenge; Socialization of new life practices are still limited; people expect the government to socialize and support in facilities. Conclusion: the level of public knowledge about COVID-19 is still lacking, but the community has practiced ways to prevent the disease; Most people speculated that the transmission and spread of the disease cannot be controlled because the community's disobedience factor in following the health protocol in their activities to fulfill economic needs; The community's preparation in implementing the new normal life still cannot be carried out due to the lack of socialization from the government and the massive hoaxes about COVID-19 disease; a systematic and concrete policy from the government is needed for the implementation of a new normal life.
Les syndromes myasthéniques congénitaux avec anomalies cinétiques du récepteur à l’acétylcholine
Authors: Islam Kediha Mohamed , Tazir Meriem , Sternberg Damien , Eymard Bruno , Ali Pacha Lamia
Published: November 2023

Les syndromes myasthéniques congénitaux (SMC) sont des affections génétiquement et phénotypiquement très hétérogènes responsables d’un déficit de la transmission neuromusculaire. Les formes dites post-synaptiques sont les plus fréquentes des SMC, et parmi elles, le déficit en récepteur à l’acétylcholine (low expressor) est le mécanisme physiopathologique le plus souvent en cause. Les SMC avec anomalies cinétiques du récepteur à l’acétylcholine sont beaucoup plus rares et à l’origine de tableaux cliniques à l’issue parfois dramatique. On en dénombre deux types : le syndrome du canal lent et le syndrome du canal rapide. Leur diagnostic et leur prise en charge thérapeutique sont spécifiques à chaque type. Dans ce travail, nous détaillerons leurs aspects phénotypiques respectifs en les illustrant par les observations de trois familles algériennes.
Le rôle inattendu des gouttelettes lipidiques dans la régulation du destin des cellules souches musculaires
Authors: Cicciarello Delia , Scionti Isabella
Published: November 2023

Les cellules souches musculaires (CSM) sont des cellules souches résidentes du muscle squelettique responsables de la régénération de ce dernier. Il est de plus en plus évident que la capacité des CSM à s’auto-renouveler ou à se différencier est influencée par le métabolisme cellulaire. Une nouvelle étude a récemment établi que les gouttelettes lipidiques (GL) sont de nouveaux régulateurs du devenir des CSM. En effet, les GL se répartissent différemment selon l’état des CSM au cours du processus de régénération, les CSM avec peu de GL étant plus enclines à s’auto-renouveler tandis que les CSM contenant beaucoup de GL s’engagent dans la différenciation. Ces résultats soulignent que le renouvellement correct des GL est nécessaire pour décider du destin des CSM. Ceci pose la question du mécanisme moléculaire sous-jacent de la régulation du métabolisme des lipides dans la détermination du destin des CSM.
Die Rechtsfrage: Kann ich WhatsApp zur Terminvereinbarung nutzen?
Authors: Schlegel Thomas
Published: November 2023

„Viele Patient*innen wünschen sich eine Kommunikation über WhatsApp, um Termine einfacher zu vereinbaren oder absprechen zu können. Ist die Nutzung von Messengerdiensten grundsätzlich erlaubt oder gibt es beispielsweise datenschutztechnische Gründe, die dies verbieten?“

Therapeutin aus Niedersachsen
Jeder Raum hat seine Wirkung – Gestaltung einer Physiotherapiepraxis
Authors: Veit Katrin
Published: November 2023

In Mario Müllers Praxis findet die erste Sitzung nie in einem Raum mit Liege statt. Der Therapeut ist der Überzeugung, dass man die Erwartungshaltung an eine Physiotherapie durch die Raumgestaltung beeinflussen kann.
Synthesis of Bioactive 1,2,3-Triazole-Fused Macrocycles via Azide-Alkyne Cycloaddition
Authors: Ansary Inul , Jahan Nasrin , Pal Arkadip
Published: November 2023

A systematic highlight of syntheses reported since 2006 of 1,2,3-triazole-fused macrocycles possessing biological activities such as anticancer, antibacterial, antiviral, anti-inflammatory and antilarval action, is presented in this review. The well-renowned Cu-catalyzed azide-alkyne cycloaddition reaction was noted to be highly efficient and is one the most common methods utilized by scientists for the synthesis of 1,4-disubstituted triazole-fused macrocycles, whereas Ru-catalyzed cycloaddition is common for the formation of 1,5-disubstituted bioactive triazoles. This review would thus be extremely beneficial for both synthetic organic and medicinal chemists.

1 Introduction

2 Anticancer Derivatives

3 Antibacterial Derivatives

4 Derivatives with Dual Activity

5 Antilarval Derivatives

6 Anti-inflammatory Derivatives

7 Antiviral Derivatives

8 Anti-trypanosomal Derivatives

9 Derivatives with Miscellaneous Activities

10 Conclusion
Impact of Early Diagnostic and Therapeutic Interventions and Clinical
Course in Children and Adolescents with Multiple Endocrine Neoplasia Types 1 and
2
Authors: Kim Ja Hye , Lee Yena , Hwang Soojin , Yoon Ji-Hee , Kim Gu-Hwan , Yoo Han-Wook , Choi Jin-Ho
Published: November 2023

Purpose Multiple endocrine neoplasia types 1 (MEN1) and 2 (MEN2) are
inherited endocrine tumor syndromes caused by mutations in the MEN1 or
RET genes. This study aimed to investigate clinical outcomes and
molecular characteristics among children with MEN.

Methods This study included eight patients from seven unrelated families.
Data on clinical course, biochemical findings, and radiologic studies were
collected by retrospective chart review. All diagnoses were genetically
confirmed by Sanger sequencing of MEN1 in three MEN1 patients and
RET in four patients with MEN2A and one patient with MEN2B.

Results Three patients with MEN1 from two families presented with
hypoglycemia at a mean age of 11±2.6 years. Four patients with MEN2A
were genetically diagnosed at a mean of 3.0±2.2 years of age by family
screening; one of them was prenatally diagnosed by chorionic villus sampling.
Three patients with MEN2A underwent prophylactic thyroidectomy from 5 to 6 years
of age, whereas one patient refused surgery. The patient with MEN2B presented
with a tongue neuroma and medullary thyroid carcinoma at 6 years of age.
Subsequently, he underwent a subtotal colectomy because of bowel perforation and
submucosal ganglioneuromatosis at 18 years of age.

Conclusion This study described the relatively long clinical course of
pediatric MEN with a mean follow-up duration of 7.5±3.8 years.
Insulinoma was the first manifestation in children with MEN1. Early diagnosis by
family screening during the asymptomatic period enabled early intervention. The
patient with MEN2B exhibited the most aggressive clinical course.
Navigating the Role of Anti-Obesity Agents Prior to Pregnancy: A Narrative Review
Authors: Goldberg Alyse S. , Dolatabadi Samin , Dutton Heidi , Benham Jamie L.
Published: November 2023

Utilization of anti-obesity agents is rising in reproductive-age females with some planning for future pregnancy. Lifestyle-induced weight loss has been shown to increase spontaneous conception rate, improve rates of fertility intervention complications, and decrease pregnancy comorbidities. However, the definitive role of assisting weight loss with medication prior to pregnancy remains to be established. The implications of anti-obesity agent used prior to pregnancy are explored in this narrative review, considering benefits of weight loss as well as available evidence for use and risks of anti-obesity agents prior to pregnancy.
A bibliometric analysis of the use of the Gamification Octalysis Framework in training: evidence from Web of Science
Authors: Mohanty Sattwik , Christopher B Prabu
Published: November 2023

The Octalysis framework, which systematically organizes gamified elements in non-game settings, such as training, has become one of the most famous persuasive tools for changing user behaviour. The field of Gamification Octalysis Framework research is expanding rapidly, moving beyond elementary questions like “what” and “why” to more complex ones like “how” and “when”. However, there remain empirical and theoretical challenges such as demonstrating the effectiveness of the Gamification Octalysis Framework and codifying the principles underpinning effective gamification design. This paper uses bibliometric analysis and scientific mapping to characterize the structure and development of the academic field of the Gamification Octalysis Framework, with the help of intellectual, conceptual, and social network structures of the framework. Our findings provide insight into the field’s research frontiers and intellectual structures, the interconnections between articles, authors, and keywords, the current collaborative networks, the hottest themes, and the most cited authors, publications, and sources, for instance, that in recent years, the Gamification Octalysis Framework has attracted significant research attention in the training field. Interestingly, 66.6% of cutting-edge research is done in the social sciences, as compared to science and technology. Researchers, academicians and professionals should be made aware of Octalysis framework gamified method because it has been shown to increase user engagement and motivation outside of social sciences game setting. We recommend that countries outside Europe integrate the Gamification Octalysis Framework in training into their learning programs and launch corresponding research centres and journals.
Ice-and-snow tourism in China: trends and influencing factors
Authors: Yang Jianping , Wang Yanxia , Tang Fan , Guo Xinyu , Chen Hongju , Ding Guangxi
Published: November 2023

Ice-and-snow tourism (IST) is central to the Chinese ice-and-snow economy and can help achieve the green transformation and expansion of the Chinese economy. However, IST has not been defined conclusively in China. In this study, the IST concept was analyzed, and the growth of both tourism types was described using an Event–Time–Space comprehensive analysis method. Two temporal phases with large increases were highlighted in both tourisms. The factors promoting their increases were analyzed from market demand, the Beijing 2022 Olympics Winter Games, and scientific and technological developments for ice and snow. The 2020–2021 decrease in IST was primarily attributed to the COVID-19 pandemic. In addition, IST has dual challenges related to natural and socioeconomic factors. Climate warming has a long-term adverse effect on IST, particularly on glacier tourism. Traditional outdoor skiing tourism in Northeast China (NEC) may also be affected by more competition owing to increased ski tourism in the pan-Beijing-Tianjin-Hebei region, the Xinjiang Uygur Autonomous Region (XJUAR) and Southern China, as well as by the development of indoor skiing and ice/snow entertainment. These natural and socioeconomic factors currently limit the ability of IST to promote socioeconomic development in alpine areas, particularly in western China. However, there are many opportunities for future IST growth, including warmed comfort climate at high altitudes in the NEC, XJUAR and the Qinghai-Tibet Plateau, major glacier resource potentials, and IST development driven by policies. The findings of this study provide important information for decision-makers and investors in IST and its related industries.
Translation quality assessment practices of faculty members of colleges of languages and translation in Arab countries: an exploratory study
Authors: Abanomey Abdulaziz A. , Almossa Samar Yakoob
Published: November 2023

The investigation and understanding of the process of assessing translation quality in translation courses have attracted some attention. However, only a few studies have explored general assessment (GA) and specialised Translation Quality Assessment (TQA) practices used by different translation instructors. This study explores the assessment practices of 98 faculty members of the translation departments of various universities in Arab countries. In this exploratory study, data were collected using an adapted version of the Approaches to Classroom Assessment Inventory instrument. In addition, the authors designed a Translation Quality Assessment Practices Inventory aimed specifically for the investigation of TQA practices adopted by the faculty members. Data collected from the three-part survey were subjected to descriptive statistics, exploratory factor analysis, one-way analysis of variance, an independent samples t-test, and the chi-square test. The study reveals that the participants highly endorsed GA and TQA practices equally. The results indicate that three major TQA themes are particularly prioritised: the significance of errors; the use of particular assessment methods; and the primacy of objectivity. This research shows that there is an urgent need for more training aimed at improving TQA literacy among faculty members teaching translation courses. It contributes to the efforts to improve translation training and to design more effective curricula.
Analysis of plasma plume parameters in physio-chemical processes of RF plasma jet plume direct in water for the inactivation of Enterococcus bacteria
Authors: Morshedian N. , Mehramiz A. , Bakhshzadmahmoudi M. , Kharaghani M. , Mohammadhosseini B. , Badrli R.
Published: November 2023

The contamination of Enterococcus bacterium is widely observed in the living environment and water. The decontamination of drinking water from the bacterial pollution is an important issue in water treatment. Here, the inactivation of Enterococcus bacteria is studied by placing the dielectric barrier discharge structure, with the RF discharge frequency of 13.56 MHz atmospheric pressure argon plasma jet, directly in water, whereas the water around the plasma plume was seething and the bubbles produced stirring all liquid volume. The ability to place a plasma jet nozzle directly in water for 10 min while maintaining a steady and uniform plasma plume, besides water temperature, provides the effectiveness enhancement in the inactivation of bacteria. The absorption of UV radiation in water is effective, and the role of UV radiation of plasma plume was mainly responsible for the destruction of peptidoglycan, which is the outer layer of Enterococcus. Then, the presence of electrons and plasma plume in water leads to the formation of hydroxyl, hydrogen peroxide, and other reactive radicals that are involved in chemical reactions, which lead to the inactivation of micro-organisms. The number of bacteria decreases from the initial value of 16 × 105 MPN/100 ml to less than 1.2 MPN/100 ml. The spectra of the plasma radiation, with the plume length 2 cm within the water, have been analyzed via the first nitrogen negative system N2+B−X. The plume temperature was calculated to be about 64 °C, which has a good agreement with water temperature measured by using a thermometer at about 67 °C after 15 min at maximum 200 W input power of the plasma jet.
Investigation of combustion process in a modular charge system with a primer gap
Authors: Ma Tianyi , Wang Hao , Tao Ruyi
Published: November 2023

To clarify the combustion process of a modular charge system with a primer gap, the rules governing the cartridge movement and pressure change in the chamber are analyzed. Based on the characteristics of the modular charge system, an axisymmetric two-phase flow model of the interior ballistics is established, with the monotonic upward-centered scheme for conservation laws adopted to calculate the combustion process. Compared with the experimental results, the difference in the peak pressure is less than 5%, which indicates that the mathematical model and scheme are reliable and accurate. The results show that, during the initial stage of ignition, the combustible container remains unbroken, and the gas and solid particles are prevented from spreading to the chamber by the end cap of the cartridge. Thus, only the gas inside the igniter tube influences the flow field in the chamber. After the combustible container has broken, the gas and solid particles move rapidly toward the cavity from the combustible container. The axial movement of solid particles is more intense than that of the gas particles, but the radial movement of solid particles is relatively weak. Furthermore, the existence of the primer gap leads to a delay in the ignition time of the solid particles, which delays the rupture time of the igniter tube and the module cartridge.
Characteristics of wake morphology during debris flow when passing a cylindrical obstacle
Authors: Cui Wen-Rong , Chen Jian-Gang , Zhao Wan-Yu , Chen Xiao-Qing
Published: November 2023

Predicting wake morphology during debris flow when passing a cylindrical obstacle is vital for disaster assessment, early warning, evacuation planning, engineering design, and ecologic conservation. It can provide a scientific foundation for pertinent decision-making processes, diminishing the risks and impacts of debris flow disasters. This study extracts the morphological characteristics of debris flow cylindrical flow traces through the steady-state motion of debris flow observed in a flume during cyclical tests. It introduces a theoretical prediction formula and compares it to empirical data. The results indicated that the morphology of debris flow cylindrical flow traces can be described as a wall-jet-like bow wave (a bow wave formed by an upward wall jet on the obstacle upstream face). The primary upstream inflow is predominantly discharged through the wall and lateral jets. Formulas for three crucial parameters that determine the morphology of the traces are derived by combining the aerodynamics theory and extant literature. The predicted outcomes strongly align with the experimental data, underscoring their high predictive precision.
Cell migration-inspired stochastic steering strategy of magnetic particles in vascular networks
Authors: Zhou Rongxin , Dong Xiaorui , Li Yanqing , Yang Zhidong , Chen Kejie
Published: November 2023

One primary challenge of magnetic drug targeting is to achieve the efficient and accurate delivery of drug particles to the desired sites in complex physiological conditions. Though a majority of drugs are delivered through intravenous administration, until now, the kinematics and dynamics of drug particles influenced by the magnetic field, vascular topology, and blood flows are still less understood. In this work, a multi-physics dynamical model, which captures transient particle motions inside the vascular networks manipulated by the external magnetic field, is developed. Based on the model, we studied the transport efficiency of particles in the two-dimensional (2D), three-dimensional (3D) artificial, and in vivo-relevant vascular networks. It is found that particles that perform a random walk with correlated speed and persistence, recapitulating some characteristics of migratory motion of immune and metastasis cells, have the largest mean square displacements in various vascular network topologies. Next, we designed a stochastic magnetic steering strategy, using a time-varying gradient magnetic field, to manipulate particles to perform the cell migration-inspired random motions in the vasculature. The capability of the proposed steering strategy to improve the particle spreading speed and reduce the consumed magnetic energy has been demonstrated using our multi-physics numerical model. Furthermore, the influence of heterogeneous flows in the vascular networks on the particle steering efficiency was investigated. Overall, the numerical model and the proposed stochastic magnetic steering strategy can be used to assist the development of drug delivery systems for precise medicine research.
Effects of bulk viscosity, heat capacity ratio, and Prandtl number on the dispersion relationship of compressible flows
Authors: Bhaumik Swagata , Deepak Sawant Omkar
Published: November 2023

Here, we present the variation of the dispersion characteristics of the three-dimensional (3D) linearized compressible Navier–Stokes equation (NSE) to bulk viscosity ratio, specific heat ratio (γ), and Prandtl number (Pr). The 3D compressible NSE supports five types of waves, two vortical, one entropic, and two acoustic modes. While the vortical and entropic modes are non-dispersive, the acoustic modes are dispersive only up to a specific bifurcation wavenumber. We illustrate the characteristics and variation of relative (with respect to the vortical mode) diffusion coefficient for entropic and acoustic modes and a specially designed dispersion function for acoustic modes with depressed wavenumber η=KM/Re, the bulk viscosity ratio, γ, and Prandtl number Pr of the flow. Here, K, M, and Re denote the absolute wavenumber of disturbances, Mach number, and Reynolds number of the flow, respectively. At lower wavenumber components, the deviation of the dispersion function from the inviscid and adiabatic case is proportional to η2 at the leading order, and the relative diffusion coefficients increase linearly with bulk viscosity ratio and γ while varying inversely with Pr. With the increase in the bulk viscosity ratio, the shape and extent of the dispersion function alter significantly, and the change is more substantial for higher wavenumber components. The relative diffusion coefficient for entropic and acoustic modes shows contrasting variation with wavenumber depending upon bulk viscosity ratio, γ, and Pr. We also show by solving linearized compressible NSE that relatively significant evolution and radiation of acoustic and entropic disturbances occur when the bulk viscosity ratio is close to the corresponding critical value of maximum bifurcation wavenumber. Based on this criterion, we have presented an empirical relation for estimating bulk viscosity ratio depending upon γ and Pr, giving the corresponding range for obtaining relatively significant disturbance evolution.
Effect of wettability on the impact force of water drops falling on flat solid surfaces
Authors: Zhang Bin , Ma Chen , Zhao Huanlei , Zhao Yinggang , Hao Pengfei , Feng Xi-Qiao , Lv Cunjing
Published: November 2023

Drops falling on substrates with varying wettability exhibit distinct morphologies. However, the relation between the impact force exerted by a water drop and the substrate wettability has not been thoroughly explored. In this paper, we investigate the effect of contact angle (ranging from 40° to 180°) on the impact force of water drops, along with the spreading diameter, rim height, and retracting velocity. Our attention is focused to the inertial regime with the Weber number ranging from 30 to 100, which enables us to rationalize the dynamic relations and to correlate the kinematics of the drop with the impact force through scaling analysis. We find that substrate wettability has insignificant effect on the first force peak, which arises mainly from the momentum change during the initial impact. However, it does influence the second force peak, which originates from the momentum change in the flow redirecting from the radial inward direction to the vertical direction, accompanied by a column-shape Worthington jet. The second peak force gradually diminishes as the contact angle decreases, until it becomes indistinguishable below 40°, while the time at which the second peak force emerges is delayed.
Fluid dynamic model for extracorporeal membrane oxygenation support and perfusion in cardiogenic shock
Authors: Vignali E. , Gasparotti E. , Haxhiademi D. , Celi S.
Published: November 2023

The venoarterial extracorporeal membrane oxygenation (VA-ECMO) is a widely adopted procedure to provide oxygenated blood support in patients who underwent cardiac shock. The current work presents a study to define a correlation between VA-ECMO support level and both systemic pressure and arterial perfusion. In this work, a numerical approach is defined on a patient-specific aortic geometry to validate this trend on a more complete case and also to investigate the behavior of the mixing zone. In particular, morphological data from computed tomography imaging of a patient-specific whole aorta, including supra aortic vessels, coronaries, and renal arteries, were adopted for the study. A computational fluid dynamic approach was set for the analysis. A total of three cardiogenic shock cases (mild, medium, and severe) were simulated. For each shock configuration, different levels of ECMO support were simulated (0–6 l/min flow range). The aortic fluid dynamics were evaluated in terms of systemic afterload, watershed zone position, and perfusion of arteries. A linear trend of the perfusion as a function of ECMO level support was investigated and successfully validated. The minimum level of ECMO support to grant the perfusion of all arteries, causing the minimum possible afterload increase, was individuated and fitted with a linear model against different levels of cardiogenic shock. The results presented demonstrated to be a first step to have a preliminary tool to establish the minimum level of ECMO support for overall perfusion as a function of cardiogenic shock percentage.