bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of estradiol on bone in men undergoing androgen deprivation therapy: a randomized placebo-controlled trial
Authors: Russell Nicholas , Ghasem-Zadeh Ali , Hoermann Rudolf , Cheung Ada S , Zajac Jeffrey D , Shore-Lorenti Cat , Ebeling Peter R , Handelsman David J , Grossmann Mathis
Published: June 2022

Objective

In men, many effects of testosterone (T) on the skeleton are thought to be mediated by estradiol (E2), but trial evidence is largely lacking. This study aimed to determine the effects of E2 on bone health in men in the absence of endogenous T.

Design

This study is a 6-month randomized, placebo-controlled trial with the hypothesis that E2 would slow the decline of volumetric bone mineral density (vBMD) and bone microstructure, maintain areal bone mineral density (aBMD), and reduce bone remodelling.

Methods

78 participants receiving androgen deprivation therapy for prostate cancer were randomized to 0.9 mg of 0.1% E2 gel daily or matched placebo. The outcome measures were vBMD and microarchitecture at the distal tibia and distal radius by high-resolution peripheral quantitative CT, aBMD at the spine and hip by dual-energy x-ray absorptiometry, and serum bone remodelling markers.

Results

For the primary endpoint, total vBMD at the distal tibia, there was no significant difference between groups, mean adjusted difference (MAD) 2.0 mgHA/cm3 (95% CI: −0.8 to 4.8), P = 0.17. Cortical vBMD at the distal radius increased in the E2 group relative to placebo, MAD 14.8 mgHA/cm3 (95% CI: 4.5 to 25.0), P = 0.005. Relative to placebo, E2 increased estimated failure load at tibia, MAD 250 N (95% CI: 36 to 465), P = 0.02, and radius, MAD 193 N (95% CI: 65 to 320), P = 0.003. Relative to placebo, E2 increased aBMD at the lumbar spine, MAD 0.02 g/cm2 (95% CI: 0.01 to 0.03), P = 0.01, and ultra-distal radius, MAD 0.01 g/cm2 (95% CI: 0.00 to 0.02), P = 0.01, and reduced serum bone remodelling markers.

Conclusion

Relative to placebo, E2 treatment increases some measures of bone density and bone strength in men and reduces bone remodelling, effects that occur in the absence of endogenous T.
Adiponectin regulates the circadian rhythm of glucose and lipid metabolism
Authors: Wada Taira , Yamamoto Yukiko , Takasugi Yukiko , Ishii Hirotake , Uchiyama Taketo , Saitoh Kaori , Suzuki Masahiro , Uchiyama Makoto , Yoshitane Hikari , Fukada Yoshitaka , Shimba Shigeki
Published: June 2022

Adiponectin is a cytokine secreted from adipocytes and regulates metabolism. Although serum adiponectin levels show diurnal variations, it is not clear if the effects of adiponectin are time-dependent. Therefore, this study conducted locomotor activity analyses and various metabolic studies using the adiponectin knockout (APN (−/−)) and the APN (+/+) mice to understand whether adiponectin regulates the circadian rhythm of glucose and lipid metabolism. We observed that the adiponectin gene deficiency does not affect the rhythmicity of core circadian clock genes expression in several peripheral tissues. In contrast, the adiponectin gene deficiency alters the circadian rhythms of liver and serum lipid levels and results in the loss of the time dependency of very-low-density lipoprotein-triglyceride secretion from the liver. In addition, the whole-body glucose tolerance of the APN (−/−) mice was normal at CT10 but reduced at CT22, compared to the APN (+/+) mice. The decreased glucose tolerance at CT22 was associated with insulin hyposecretion in vivo. In contrast, the gluconeogenesis activity was higher in the APN (−/−) mice than in the APN (+/+) mice throughout the day. These results indicate that adiponectin regulates part of the circadian rhythm of metabolism in the liver.
The nuclear receptors SF1 and COUP-TFII cooperate on the Insl3 promoter in Leydig cells
Authors: Di-Luoffo Mickaël , Pierre Kenley Joule , Robert Nicholas M. , Girard Marie-Joëlle , Tremblay Jacques J.
Published: June 2022

Insulin-like 3 (INSL3), a hormone abundantly produced by Leydig cells, is essential for testis descent during foetal life and bone metabolism in adults. The mechanisms regulating Insl3 expression in Leydig cells have been studied in several species but remain poorly understood. To date, only a handful of transcription factors are known to activate the Insl3 promoter and include the nuclear receptors AR, NUR77, COUP-TFII, and SF1, as well as the Krüppel-like factor KLF6. Some of these transcription factors are known to transcriptionally cooperate on the Insl3 promoter but the mechanisms at play remain unknown. Here we report that COUP-TFII and SF1 functionally cooperate on the Insl3 promoter from various species, but not on the Inha, Akr1c14, Cyp17a1, Hsd3b1, Star, Gsta3, and Amhr2 promoters that are known to be regulated by COUP-TFII and/or SF1. The Insl3 promoter contains species-conserved binding sites for COUP-TFII (−91 bp) and SF1 (−134 bp). Mutation of either the COUP-TFII or the SF1 sequence had no impact on the COUP-TFII/SF1 cooperation but mutation of both binding sites abolished the cooperation. In agreement with this, we found that COUP-TFII and SF1 physically interact in Leydig cells. Finally, we report that the transcriptional cooperation is not limited to COUP-TFII and SF1 as it also occurred between all NR2F and NR5A family members. Our data provide new mechanistic insights into the cooperation between the orphan nuclear receptors COUP-TFII and SF1 in the regulation of Insl3 gene expression in Leydig cells.
Multilistas aplicadas a la implementación de un parseador de XML para la definición de XPDL 2.2 en Objective C para iOS
Authors: Meza Lara Daniel Iván , Ruiz Rodríguez Leidy Andrea , Herrera Bedoya Óscar Elías
Published: June 2022

En este trabajo se expone la implementación de estructuras de datos en el desarrollo de un parseador que permite la interpretación de archivos XPDL (XML ProcessDefinitionLanguage) en su versión 2.2, mediante multilistas. Junto con el metamodelo propio del XPDL se busca solucionar una problemática en la interpretación del esquema XML, permitiendo un correcto almacenamiento de los elementos bajo el lenguaje Objective C para iOS, con el cual se pretende innovar en el campo de las plataformas móviles que hacen uso del lenguaje estándar BPMN (BusinessProcessModeling Notation) para la representación de procesos de negocio y que generan el XPDL. El objetivo principal de un XPDL es describir la información del flujo de datos del proceso mediante un esquema XML (Extensible MarkupLanguage).
Evaluation of the Reliability of Electrocardiographic Criteria for Cardiac Hypertrophy Based on Echocardiographic Data
Authors: Augustaitytė Agnė , Kalinauskienė Eglė
Published: June 2022

Background. Left ventricular hypertrophy (LVH) regardless of other risk factors may be associated with an increased risk of mortality from cardiovascular diseases. Therefore, timely diagnosis for LVH is important in order to avoid possible complications. One of the simplest and cheapest methods to diagnose LVH is electrocardiography (ECG). Although a number of ECG criteria for LVH is known, their reliability varies in many studies.Aim. To evaluate the reliability of ECG criteria for LVH based on transthoracic echocardiography (TTE) data.Methods. The study included all consecutive patients in Kaunas Clinical Hospital Department of Cardiology from December 2019 until March 2020 and from September until October 2020, after applying the inclusion and exclusion criteria. The sensitivity and specificity of the ECG criteria for LVH were assessed based on TTE measurements performed during the same inpatient setting. The reliability of the ECG criteria for LVH was assessed using ROC curves. Reliability differences in gender, age and nutritional status groups were assessed using ANOVA statistical method.Results. Data from 95 patients were analyzed (63.2% were women and 36.8% were men). The sensitivity, specificity and AUC of Sokolow–Lyon criterion were 9.38%, 85.71% and 0.44 (p = 0.034), R in aVL – 6.25%, 90.48% and 0.51 (p = 0.038), Cornell – 21.88%, 100 % and0.69 (p = 0.084), Cornell product – 31.25%, 95.24% and 0.72 (p = 0.070), Peguero–Lo Presti – 31.25%, 85.71% and 0.68 (p = 0.053), respectively. No statistically significant differences were observed among the individual gender, age and nutritional status groups.Conclusions. Sokolow–Lyon and RaVL criteria were not statistically significantly reliable in LVH diagnosis compared to TTE, unlike the Cornell, Cornell product, and Peguero–Lo Presti criteria.
Intervenção psicopedagógica em caso de criança com neurofibromatose tipo 1
Authors: Lumertz Fábia Daniela Schneider
Published: June 2022

Este artigo é um relato de experiência de caso clínico de intervenção psicopedagógica por mediação lúdica com criança acometida de neurofibromatose tipo 1.  Seu objetivo é relatar um excerto do caso, em que foi usada a intervenção psicopedagógica por mediação lúdica na estimulação e organização das funções psíquicas superiores do sujeito deste estudo, com foco especial em controle de comportamentos, planejamento das ações e função simbólica, a fim de promover seu desenvolvimento psíquico e ampliar sua capacidade de aprendizagem. O estudo usa metodologia qualitativa e parte do pressuposto vigotskiano da pesquisa como processo, que, ao mesmo tempo em que pesquisa, promove mudanças na realidade pesquisada. A metodologia usada nas intervenções foi a abordagem psicopedagógica por mediação lúdica de base conceitual na Teoria Histórico-Cultural do desenvolvimento psíquico humano. Como resultados, observamos o desenvolvimento do menino, que, ao final de dois meses de intervenções, estava mais organizado, controlando as suas ações dentro dos contextos propostos e iniciando o brincar de forma simbólica.
Molecular mechanisms highlighting the potential role of COVID-19 in the development of neurodegenerative diseases
Authors: Rahmani Behrouz , Ghashghayi Elham , Zendehdel Morteza , Baghbanzadeh Ali , Khodadadi Mina
Published: June 2022

Coronavirus disease 2019 (COVID-19) is a contagious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In addition to the pulmonary manifestations, COVID-19 patients may present a wide range of neurological disorders as extrapulmonary presentations. In this view, several studies have recently documented the worsening of neurological symptoms within COVID-19 morbidity in patients previously diagnosed with neurodegenerative diseases (NDs). Moreover, several cases have also been reported in which the patients presented parkinsonian features after initial COVID-19 symptoms. These data raise a major concern about the possibility of communication between SARS-CoV-2 infection and the initiation and/or worsening of NDs. In this review, we have collected compelling evidence suggesting SARS-CoV-2, as an environmental factor, may be capable of developing NDs. In this respect, the possible links between SARS-CoV-2 infection and molecular pathways related to most NDs and the pathophysiological mechanisms of the NDs such as Alzheimer's disease, vascular dementia, frontotemporal dementia, Parkinson's disease, and amyotrophic lateral sclerosis will be explained.
Paul Draper, Agnostisizm ve Kötülük Problemi
Authors: ASLANTATAR Nesim
Published: June 2022

Kötülük probleminin, genellikle, ateizmin bir delili olduğu kabul edilir. Ancak bu varsayımın zorunlu olmadığının kanıtı olarak bazı düşünürler örnek gösterilebilir. Örneğin, literatüre kazandırdığı eserlerine baktığımızda kötülük problemininin kendisi için büyük bir problem olduğunu söyleyebileceğimiz, günümüz din felsefesinin önde gelen düşünürlerinden Paul Draper, kendini agnostik olarak tanımlar. Draper, kötülüğün doğrudan agnostisizmi desteklediğini savunmaz, daha ziyade, ateizmi tek başına kanıtlayacak gücü olmadığını savunur. Açıktır ki, kötülük probleminin Draper için yeterince kanıtlama gücü olsaydı, kendisinin agnostik değil ateist olması beklenirdi. Bu çalışmayla, kötülük probleminin, genel olarak, ateizmle ilişkilendirildiği bir ortamda, Draper’in, agnostisizmi nasıl temellendirdiğini ortaya koymayı amaçlamaktayız. Draper’in kötülük problemi ve agnostisizmi konu edinen çalışmaları ile litaratürde söz konusu tartışmayı ele alan ve Draper’e çeşitli tenkitler yönelten çalışmalara dair eleştirel bir okuma neticesinde, kötülük probleminin neden zorunlu olarak ateizmin bir gerekçesi olamayacağını gösterebilmeyi hedefliyoruz. Aynı şekilde, agnostisizmin temellendirilmesi noktasında, Draper’in litarürde durduğu noktayı açıkça gösterebilmek amacıyla, agnostisizmin temellendirilmesi tartışmasına kısaca değinecek ve Draper’in ‘kötülük probleminden agnostisizme’ geçişinin, ‘kötülükten ateizme’ herhangi bir geçişten daha rasyonel olduğu sonucuna ulaşacağız.
Special Issue: Similar Challenges in a Different Setting: Racism and Higher Education in Prison
Authors: Taylor Satra D. , Daniel (Jones) Michelle , Elliott Kayla C. , Muhammad Bahiyyah , Corbett Erin , Steib Syrita
Published: June 2022

This Special Issue is a labor of love from activists, professors, practitioners, and community organizers committed to addressing racial inequity in higher education in prison. Amid an ongoing pandemic, people across the globe wrote, read, and revised thought-provoking pieces in hopes that they would transform one’s thoughts. This Special Issue predominately features articles authored by individuals impacted by incarceration to provide those closest to the issues with a platform to recommend solutions.
Development of a Universal Running Time Predictor using Multivariate Regression
Authors: Khan Farhan Hai , Pal Tannistha , Roy Rounik
Published: June 2022

Various types of running times exist for analysis of algorithmic efficiency. This research presents a more empirical approach to the problem for the practical measurements of the actual running time of algorithms by considering a plethora of randomized inputs Rn and then
fitting a regression curve in n to the algorithm of practical time complexity ν (n). This will also provide us the productivity factor η which will quantify the universal running time with respect to the asymptotic worst-case complexity and evaluate the efficiency of the given algorithm
with the help of leading coefficients. This research will also help us compare similar algorithms in a mathematically modelled manner.
Optimal reservoir operation using parametric elitist cuckoo search algorithm
Authors: Trivedi M. , Shrivastava R. K.
Published: June 2022

Optimal reservoir operation has become a challenging problem due to streamflow uncertainties. Frameworks for optimal reservoir operation play a vital role in the management of water resources. Effective and judicious utilisation of water from reservoirs helps in the management of periods of water deficit. The main objective in reservoir optimisation is to design operating rules that can be used to derive real-time decisions on reservoir release. In this study, a metaheuristic optimisation algorithm – the parametric elitist cuckoo search algorithm (Pecsa), based on the basic cuckoo search algorithm (CSA) – was applied to develop optimal operation decisions for the RSSR in the MRP, India. To evaluate the performance of Pecsa, the results obtained were compared with another heuristic method (the time-variant elitist mutation particle swarm optimisation algorithm) and with the standard CSA and particle swarm optimisation methods. Pecsa was found to improve system operation and outperformed the other methods in terms of achieving a faster convergence rate. Pecsa also showed only minor variations in the optimal pattern of release policies compared with those obtained using the standard CSA. The implications of the results and suggestions for further research are discussed.
Sexual violence against children in the light of analysis by the Parliamentary Assembly of the Council of Europe
Authors: Jaskiernia Jerzy
Published: June 2022

Sexual violence against children is a serious challenge for the contemporary international community. Ways of more effective counteracting this phenomenon are being sought. A special role plays in this process Council of Europe’s Convention on the Protection of Children against Sexual Exploitation and Sexual Abuse (Lanzarote Convention), CETS No. 201. The Parliamentary Assembly of the Council of Europe, in Resolution 2330 (2020) and Recommendation 2175 (2020) Addressing sexual violence against children - stepping up action and co-operation in Europe, adopted on June 26, 2020, assessed the situation in this area in Europe and presented recommendations on the issue of combating this phenomenon more effectively. The dangers in this area during the Covid-19 pandemic play a significant role in this process. The author analyzed these PACE documents in broader context of research on this subject and emphasized their importance for international efforts to combat sexual violence against children.
Working towards the Sustainable Development Goals: quality digital education during COVID-19
Authors: Ostáriz Pablo Lafarga , Costa Rebecca Soler
Published: June 2022

The last few years have shown a clear commitment to digital. In the case of the educational field, this new direction is being promoted by global objectives, such as the Sustainable Development Goals (SDG), specific legislation by each country, or technological progress itself. The Massive Open Online Courses (MOOC) can be a good interrelation of all of them, especially in view of the arrival of the pandemic caused by the Covid-19. A digital proposal whose growth during the second decade of the 21st century has been very significant, some reasons to consider are how it favors lifelong learning and both synchronous and asynchronous teaching-learning methods. That is why in this article we intend to provide a reflective analysis of the necessary rethinking of education today and what the role of the MOOC can be in this new context.
Parental attitudes towards children in the first educational stage
Authors: Żeber-Dzikowska Ilona
Published: June 2022

The subject of the study is parental attitudes towards a child in the first educational stage. The study demonstrated parental attitudes and their significance in child’s development and upbringing.The aim of the study and the author’s matter of concern was the most common parental attitudes towards children in the first educational stage. Parents’ views on attitudes, proper child-raising and pedagogical difficulties have been discussed. And also how parents broaden their knowledge of child upbringing.The interpretation of the research findings led to conclusions that, according to parents, the most common attitudes are: demanding, cooperative and overprotective ones. Living in a multi-child family and family breakup affect attitudes toward children.
Social work with women in the community
Authors: Kravchenko Oksana , Kucher Galyna
Published: June 2022

The article summarizes the regional aspects of the innovative experience of developing a system of measures to ensure equal rights for women and men, identifying effective tools for implementing this system. It is established that such innovative approaches are introduced in the city of Uman, the coordination center of which is the Department of Labor and Social Protection of the Uman City Council.Among the main achievements on the way to gender equality and respect for women's rights are the following: approved social program to combat human trafficking for the period 2015 - 2020; City Social Program for Gender Equality for the period 2015-2020; there is a mobile brigade of social and psychological assistance to persons who have suffered from domestic violence and / or gender-based violence; the decision of the Uman City Council "On accession to the European Charter for Equality of Women and Men in the Life of Local Communities" was adopted; The Procedure for Interaction of Entities Carrying Out Measures in the Sphere of Prevention and Counteraction to Domestic Violence and Gender-Based Violence, etc. has been developed and approved.In accordance with these programs, measures are taken to prevent the occurrence of domestic violence, gender-based violence and human trafficking.
In defense of children’s rights. Social-legal status of a child in the Second Republic of Poland
Authors: Salata-Zasacka Lidia
Published: June 2022

In the Second Polish Republic, a number of different acts of law were introduced to standardizeand regulate the social and legal status of children. Yet, it was difficult to put into practice thewritten demands due to the years of partitions, the war, and poverty, which caused to create too relaxed family ties, the increase in the number of orphans, homelessness and the appearance of morally neglected children. In the inter-war period, the homogeneous and well-planned childcarebecame a prestigious issue. The educators themselves stood up for the children's rights to maintain their lives in dignity and joy. Apart from the educators, the issue became the subject of the various heated discussions of doctors, lawyers and educational activists. The concepts of reforming the educational care system were raised (the insufficiencies and wrongdoings in the work of the individual institutions were revealed), the organisation of special education, the staff training, as well as the attempts were made to develop the scientific basis in the sphere of childcare pedagogy.
Quality of preschool education as necessary condition her of modernization
Authors: Біляковська Ольга
Published: June 2022

The problem of quality of education is one of the central problems in modern educational politics and science. The author considered scientific researches in which questions of quality of preschool education and its measurement are covered. The basic concepts of the research, namely, “quality of education”, “quality of preschool education”, “monitoring”, “psychological and pedagogical monitoring” are defined. The main objective of preschool education is to the creation of conditions to ensure children with quality preschool education. The author substantiation the factors of improving the quality of preschool education; the quality criteria of preschool education are characterized. Only the high quality of preschool education will be able to satisfy the modern demands of parents and society.
Bilingual education in Ukraine and Poland: francophone context
Authors: Винарчик Марія
Published: June 2022

The problem of bilingual education, which is the use of a foreign language for teaching non-linguistic disciplines is analyzed in the article. The process of formation of bilingual education in the francophone context in Ukraine and Poland is studied. It was established that the introduction of bilingualism in the field of education was carried out with the support of the Ministry of Education of both countries. The French embassies in Ukraine and Poland provide comprehensive support and assistance. In the modern conditions of modernization of the educational branch, deepening of intercultural cooperation and interaction, bilingual education acquires special value. It aims to foster a sense of tolerance and openness to different cultures. It is established that the basis of bilingual education is creative pedagogical activity, which promotes creative and comprehensive development of personality.
NATO and the Warsaw Pact in defence politics of the Socialist Federal Republic of Yugoslavia in the second half of the 20th century
Authors: Gregorczyk Dariusz
Published: June 2022

After the year 1945 and during the Cold War, the defence politics of the Socialist Federal Republic of Yugoslavia (SFRJ) in regards to NATO was determined by the country's international politics and its geostrategic placement. The geopolitical situation of the Socialist Federal Republic of Yugoslavia was extremely complicated due to its borders shared with NATO and the Warsaw Pact countries. The communist government of Yugoslavia, and the leaders of the Yugoslav People's Army, expected the SFRJ territory to become a warzone should the conflict between the two political blocks escalate to military action. One of the key elements of the doctrine of the SFRJ politicians and military elite was a plan of defense solutions in case of a NATO aggression. The defence strategies of the YPA, especially after 1968, also took into account a possibility of the Warsaw Pact forces entering the country. The defence plans prepared for a NATO aggression were based mostly on the experiences of World War II, expecting the SFRJ territory to be one of the important elements of a future war between the two blocks.
The Conservative Revolution During the Weimar Republic and its Impact on the Young German Generation in the Years 1919–1933
Authors: Butkiewicz Tomasz
Published: June 2022

In the historical and political literature we will not encounter such a diverse and, in its impact, individually ambiguous term as the “conservative revolution”. Although it is possible to place it within one of its creators, in the application of its practices we will come across many substantive discrepancies. This is certainly due to the creative idea of the people and the language that the revolutionaries used. In the basis of this historical-political dialogue, although the dissertation is concerned only with the period of the Weimar Republic, we can see the changes already taking place in the second half of the 19th and early 20th centuries. Thus to this day Friedrich Nietzsche is regarded as the spiritual father of the “conservative revolution”. The cult of the “superman” (Übermensch) he created (Übermensch) broke the ties with the hitherto values of Christianity in favour of crossing out God's universe in the world. For many intellectuals, it represented a theoretical-cognitive pluralism in the recording of moral tables for modern humanity. Nietzschean nihilism, as a construct of the “superman”, uprooted youth from bourgeois structures, and thus from their duty of service to their elders, guiding them towards the heroic realm. In its dimension, it overcame the statu quo of the time in favour of renewal and liberation towards the inner evolution of the “superman”. It resulted from the constant struggle and persistence of a reality which the “superman” then created himself. The significance of the Nietzschean construct for the fundamental ideas of the “conservative revolution” was best summed up by Thomas Mann. In his original reflections on the apolitical man, he shattered the previous norms of political structure in favour of the heroism awakening in youth. Subsequent intellectuals who were unquestionably counted among the founders of the revolutionary idea of the Weimar period agreed with this thought: Ernst Jünger, Ernst Julius Jung, Carl Schmidt, Wilhelm Stapel. The acolyte of the young revolutionaries' thought became the First World War. It broke the link with the pre-industrial mentality in favour of militant-apologists, from whom a new state elite was to crystallise. It was to create a hierarchy of cadres based on society. Thus, among the soldiers on the battlefield, the idea of defence of the homeland and sacrifice on the altar of war was born. Internally, it created an anthropology and philosophy of war to which the German youth was called. This sense of struggle was to evolve from defeat into a new different Germany: “we had to lose the war in order to win Germany”. The National Socialists, after coming to power in 1933, were keen to use the educational concept of the „conservative revolution” and the youth organisations of the late 19th and early 20th centuries. Nazi pedagogy drew on these reservoirs as a model for creating the Third Reich's ideal of the “new man”.
The Phenomenon of the Resurgent Republic of Poland after the Partitions of Poland, or the Poles’ Struggle for Eastern Galicia in 1918–1923
Authors: Makowski Marek
Published: June 2022

Complicated ethnic relations and the awakening national identity of the Ukrainians, further stimulated by the collapse of the Austro-Hungarian Empire, spurred the efforts of the Ukrainian population of eastern Galicia to assert their independence. The lands of this province became a disputed area between Poles and Ukrainians. Its capital city of Lviv, overwhelmingly populated by Poles, naturally aspired to reunite with the Polish Republic, which was reborn after more than 120 years. The chaos caused by the collapse of the Habsburg Empire and the lack of clear decisions about the future of the disputed lands led to fighting in Lviv and other cities of the province. The end of hostilities in July 1919, which was victorious for the Polish side, did not lead to a final settlement at the peace conference in Paris. At that time, Polish diplomacy faced the task of convincing the Entente states to grant the territory of Eastern Galicia to Poland. These efforts were successful, and the province eventually became part of Poland in the first quarter of 1923.
Substitutability between Balance Sheet Reductions and Policy Rate Hikes: Some Illustrations and a Discussion
Authors: Crawley Edmund , Gagnon Etienne , Hebden James , Trevino James
Published: June 2022

This note explores the substitutability between policy rate hikes and reductions in the size of the Federal Reserve's balance sheet for the removal of policy accommodation. We do so using a version of the FRB/US model augmented to incorporate the effects of changes in the Federal Reserve's asset holdings on term premiums.
Mecelle'de Beyyineler Arasında Teâruz ve Tercih
Authors: Mazlum Elif
Published: June 2022

Geçmişten günümüze insanlar, yaşadıkları anlaşmazlıkları âdil bir şekilde çözmeye ihtiyaç duymuş ve mahkemelerde iddialarını çeşitli delillerle savunmuşlardır. İslâm mahkemelerinde hâkimler, sunulan beyyineleri klasik fıkıh kaynaklarına dayanarak değerlendirmişlerdir. Osmanlı döneminde hâkimlerin işlerini kolaylaştırmak ve hukukî istikrarı sağlamak gibi bazı hedeflerle bir kanun metni şeklinde oluşturulan Mecelle-i Ahkâm-ı Adliyye’de, ispat vasıtaları konusuna genişçe yer verilmiştir. Bu çalışmanın amacı, Mecelle’deki beyyineler arasında teâruz ve tercih ile alâkalı maddeleri değerlendirmektir. Araştırma yapılırken genellikle klasik kaynaklarda yer alan mezhepler arasındaki temel ihtilâflara da değinilmiştir. Birbiriyle teâruz eden beyyineler arasında tercih yapabilmenin, davacı ve davalı tarafların tespit edilebilmesine dayandığı gözlemlenmiştir. Davacının beyyine getirmekle yükümlü olması, her iki tarafın da delil sunduğu ya da bundan âciz kaldıkları durumlarda iddialar arasında tercih yapmayı sağlayan bir kuraldır.
Spatial and temporal evolution of olive cultivation due to pest attack, using remote sensing and satellite image processing
Authors: Pino Vargas Edwin Martin , Huayna Germán
Published: June 2022

Climate change, as well as the appearance of pests and diseases, are affecting olive plantations (Olea europaea L.) and the production of olives in the world, therefore, there is an urgent need for tools to help us identify the spatial and temporal evolution of the olive groves, regarding the attack of pests, in this case, the Orthezia olivicola and the olive borer Phloeotribus scarabaeoides. In this work, we use information from freely available satellite images that allowed us to carry out spatial and temporal analysis and the combination of vegetation indices. For the studied area, according to the values of the NDVI (Normalized Difference Vegetation Index), it was identified that the surface of diseased plants ranges from 42% to 68%, moderately healthy plants from 2% to 18%, and the state of the plantation considered as very healthy plants with a tendency to zero, which means that practically 100% of the olive trees are affected by some level. The temporal variation of the NDVI, DVI, SAVI, GNDVI, EVI2, and MSAVI indices, allowed us to establish the states of affectation as mild, moderate pest attack, the severity of the pest attack added to the water deficit, and very strong pest attack and state of permanent wilting.
GUARDS Statistical Analysis Plan v1
Authors: Catherine Williamson Professor
Published: June 2022

GUARDS is a double-blind randomised placebo-controlled single site trial. The participating centre in Spain will be Clinic University Hospital “Virgen de la Arrixaca” in Murcia. Women with an abnormal oral glucose tolerance test (OGTT) screen will be offered participation. After written informed consent, eligible women will be randomly assigned to UDCA or placebo at 24+0-30+6 weeks’ gestation until birth. All participants will be offered standard antenatal care, aiming for the GEDE guideline targets of blood glucose concentration between 3.9-7.8mmol/L (70 - 140 mg/dL). We will assess clinical efficacy, mechanisms of action and acceptability of UCDA in study participants. Clinical efficacy will be measured by maternal-infant glucose control using conventional capillary and novel continuous glucose measures and standard clinical measures for serum lipids (total, HDL- and LDL-cholesterol, triglycerides and total free fatty acids). Acceptability will be measured by patient compliance (pill counts) and confirmed by serum measurements of individual bile acids (including UDCA). Serum samples will be taken for UPLC-MS/MS measurement of bile acids (including UDCA), so it will be clear if women have taken (and absorbed) the drug. Obstetric and neonatal outcomes will be measured. This Statistical Analysis Plan sets out how we will analyse the trial.
[RETRACTED] Viv Keto Gummies-shark tank, reactions, fixings and Cost , where to buy? v1
Authors: not provided ViaKetobuy
Published: June 2022

[RETRACTED]

Indeed, certain individuals get keto influenza side effects initially, which is definitely not a major issue.
A parallel transcriptomics and proteomics workflow for organisms with minimal reference protein databases v2
Authors: Thuy-Boun Peter
Published: June 2022

This is a method that lets researchers perform mass spectrometry-based proteomics experiments and build a new reference protein database to help interpret that data in parallel work streams. In our case, we used it to study the lone star tick, Amblyomma americanum, but the approach is applicable to any understudied organism.
[RETRACTED] Condor CBD Gummies v1
Authors: CBD Gummies Condor
Published: June 2022

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[RETRACTED] Ree Drummond CBD Gummies v1
Authors: not provided matychjtr
Published: June 2022

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[RETRACTED] Cherry Time Gummies Is Healthy Weight Loss Your Body's Fat Burning Intensity! v1
Authors: not provided health
Published: June 2022

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Health
Field- versus laboratory-based estimates of muscle quality index in adolescents with and without Down syndrome v1
Authors: Leite Rodrigues Melo Geiziane
Published: June 2022

Background Low muscle quality index (MQI) is a potential risk of developing functional impairments in older people. However, considering that individuals with Down syndrome (DS) present with a faster decline in biological aging, an investigation on MQI in individuals with DS is necessary. The aims of this present cross-sectional study were to compare (1) MQI between adolescents with and without DS and (2) evaluate laboratory versus field-based estimates of MQI. Methods Fifty-six adolescents were recruited and separated into two groups: DS (n=30, 13 boys, 17 girls; age: 12.38 ± 3.07 years) and a control (non-DS; n = 26, 9 boys, 17 girls; age: 12.46 ± 2.88 years). Laboratory MQI was derived from the ratio of grip strength to arm muscle mass (in kg) measured by dual-energy x-ray absorptiometry (DXA). Field-based MQI was quantified from the ratio of hand grip strength (HGS) to body mass index (BMI). For statistical analyses, a two-way ANOVA was conducted for group comparisons, and a Pearson correlation was used to test the association between field MQI and laboratory MQI. Results Adolescents with DS displayed lower field (p=0.001), laboratory MQI estimates (p=0.001) and HGS (p=0.001) as compared non-DS. Also, there was a strong correlation effect between field MQI and laboratory MQI estimates (p < 0.001, R=0.81). Conclusion Adolescents with DS have lower field and laboratory MQI compared to adolescents without DS. Simpilier field MQI might be used in daily clinical practice, with special attention to those with DS.
[RETRACTED] MEMBER-OWNER 003 v1
Authors: not provided rober
Published: June 2022

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[RETRACTED] Vital Origin ErgoMax (Professionel Review) Does Vital Origin ErgoMax Really Works? v1
Authors: Origin ErgoMax Vital
Published: June 2022

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Design of a tribotechnical diagnostics model for determining the technical condition of an internal combustion engine during its life cycle
Authors: Furch Jan , Jelínek Josef
Published: June 2022

The paper proposes a model of tribotechnical diagnostics, which allows us to determine
the technical condition of an internal combustion engine within its life cycle and then take
measures, including its decommissioning due to excessive wear of major components. The
paper also focuses on tribodiagnostic methods that are suitable for assessing the technical
condition of internal combustion engines used in various means of transport (automobiles,
railway locomotives powered by internal combustion engines, aircraft powered by reciprocating internal combustion engines, special and garden equipment). An internal combustion engine from agricultural equipment was selected for the experiment and monitored
throughout its life cycle. The paper describes in detail the appropriate methods used for the
proposed tribotechnical diagnostics model, including the results from the measurements by
these methods. The said methods were then evaluated and mutually compared. The following advanced instrumental analytical methods were used to evaluate the collected engine
oil samples: atomic emission spectrometry (AES), ferrography, automatic laser counter and
LNF particle classifier, FTIR infrared spectrometry. The result of the work (paper) is the
design of a tribotechnical diagnostics model for determining the technical condition of an
internal combustion engine during its life cycle and the determination of limit values for assessing the technical condition of a Honda GCV 165 internal combustion engine. The results
are based on individual measurements
REFLEXÕES ACERCA DOS IMPACTOS BIOPSICOSSOCIAIS DO VAZAMENTO DE ÓLEO NA COSTA BRASILEIRA
Authors: Reis do Nascimento Isabelle Iorrane , Da Silva Cardoso Lilian , Costa Ferreira Mariana , Costa Cleberson Franclin Tavares
Published: June 2022

O debate acerca dos desastres e das situações de emergência ganhou destaque nos últimos anos, já que esses são eventos com alto potencial para desencadear uma série de consequências físicas, psíquicas e sociais. Objetivou-se discutir os aspectos biopsicossociais referentes ao derramamento de óleo em 2019 no litoral brasileiro. Trata-se de um estudo bibliográfico, realizado por meio de dados secundários, já coletados e analisados. Utilizou-se dados governamentais; não-governamentais; e estudos científicos publicados em periódicos com revisões por pares, com data de agosto de 2019, início da visualização do óleo no litoral brasileiro, até novembro de 2020, período de finalização deste. Como resultados discutidos, se iniciou através histórico do fato e as suas consequências socioambientais, danos à fauna e flora, assim como à vida daqueles que dependem das atividades no mar, como pescadores, consumidores e voluntários. Discutiram-se e foram evidenciadas fragilidades nas políticas ambientais brasileiras, principalmente no que tange ao Plano Nacional de Contingência, pelo retardo no acionamento deste. Evidenciou-se ainda a contribuição da Psicologia nas dimensões biopsicossociais, nas subjetividades e idiossincrasias dos seres humanos frente à resiliência, luto, noção de pertencimento/vínculo com o lugar e vulnerabilidades sociais. Conclusivamente, refletiu-se acerca do gap de ações governamentais amplas, que possam auxiliar na reparação de danos, na esfera humana, com ações focadas na dimensão biopsicossocial, ou voltadas a recuperação dos ecossistemas atingidos.
COBERTURA VACINAL POR INFLUENZA VÍRUS NOS ESTADOS BRASILEIROS ANTES E APÓS O COVID-19
Authors: Gaujac Cristiano , Cunha Rafael Soares da , Amaral Regiane Cristina do
Published: June 2022

Objetivo: comparar cobertura vacinal nos Estados brasileiros por Influenza Vírus no período de 2019 a 2020.

Metodologia: estudo observacional em que foram utilizados dados do DATASUS. Realizadas análises de séries temporais para a cobertura vacinal no período de 2000 a 2019. Foram ainda realizados teste t de Student comparando a cobertura vacinal contra o Influenza vírus nos anos de 2019 e 2020.

Resultados: foram verificadas as variações percentuais anuais (VPA) nos Estados brasileiros dos anos de 2000 a 2019, sendo verificado um percentual estacionário em relação a cobertura vacinal na maioria dos Estados. Em relação a cobertura vacinal contra o Influenza vírus, no período de 2019 e 2020 (campanhas vacinais), verifica-se diferença estatisticamente significativa para os grupos avaliados, exceto indígenas (p=0,97) e total (p=0,19), teste t de Student.

Conclusão: A pandemia do COVID 19 prejudicou grupos populacionais quanto a vacinação contra o Influenza vírus, como gestantes, crianças e puérperas.
TENDÊNCIA TEMPORAL DE MORTALIDADE POR DIABETES MELLITUS NO ESTADO DE SERGIPE E SUAS REGIÕES DE SAÚDE NO PERÍODO DE 11 ANOS
Authors: Lima Sonia Oliveira , Oliveira João Pedro Nascimento de Abreu , Coelho Anny Catarina Sousa , Vieira Felipe Gustavo Santana Reis , Nardelli Maria Julia , Nunes Marco Antonio Prado , Jesus Carla Viviane Freitas de
Published: June 2022

RESUMO: A incidência e as taxas de mortalidade por Diabetes Mellitus (DM) têm apresentado crescimento progressivo, no mundo. Objetivou-se avaliar a tendência de mortalidade por DM no estado de Sergipe e nas suas regiões de saúde, entre os anos de 2008 e 2018. Trata-se de um estudo ecológico, descritivo e de série temporal, com dados secundários notificados de óbito por DM, obtidos por meio da base de dados Sistema de Informações de Mortalidade, disponibilizado pelo Departamento de Informática do Sistema Único de Saúde. A análise temporal foi realizada com aplicação do modelo de regressão por pontos de inﬂexão Joinpoint Regression Analysis. Os óbitos por DM em Sergipe foram altos, prevalecendo no sexo feminino, com idade superior a 60 anos, cor parda e negra e com escolaridade até 3 anos. Na análise temporal, no período de 11 anos, em Sergipe a taxa média de mortalidade foi de 1,4% ao ano. Nas regiões de saúde, em Aracaju a taxa foi de 3,1% e em Estância de 2,6% ao ano, com crescimento progressivo significativo (p<0.05). Enquanto a região de saúde de Lagarto, apresentou uma redução progressiva significativa de -1.5% (p<0.05). As demais regiões apresentaram tendência neutra de óbitos por DM. Conclui-se que a tendência de mortalidade decorrente do DM no estado de Sergipe é alta e crescente, sendo o presente estudo, uma ferramenta útil para os profissionais de saúde otimizarem estratégias preventivas, diagnósticas e terapêuticas com ações contínuas e permanentes, com o intuito de reduzir a mortalidade dessa doença crônica, porém de carácter benigno.
EFEITO DA QUALIDADE DO AR E VARIÁVEIS METEOROLÓGICAS NAS INTERNAÇÕES POR DOENÇAS CRÔNICAS NÃO TRANSMISSÍVEIS
Authors: Ruppenthal Fernanda , Mittelstadt Eduarda Sthefanie , Machado Aline Belem , Bueno André Luis Machado , Osorio Daniela Montanari Migliavacca , Berlese Daiane Bolzan
Published: June 2022

A exposição à poluição atmosférica gera efeitos negativos à saúde humana, potencializando diversas doenças pré-existentes na população. Devido aos efeitos deletérios dos poluentes, eles são considerados um fator de risco para o desenvolvimento de doenças crônicas não transmissíveis (DCNT). As variáveis meteorológicas interferem nos níveis destes poluentes na atmosfera, impactando na exposição da população a esses poluentes. Este estudo avaliou a associação entre a qualidade do ar, variáveis meteorológicas e o número de internações hospitalares por doenças crônicas não transmissíveis no município de Canoas-RS, entre janeiro de 2014 a dezembro de 2018. Tratou-se de um estudo transversal, descritivo e retrospectivo das relações entre a qualidade do ar e variáveis meteorológicas, com as ocorrências de internações hospitalares por doenças crônicas não transmissíveis, no município de Canoas-RS. O estudo abrangeu o período de janeiro de 2014 a dezembro de 2018. A correlação estatística entre esses fatores foi utilizada a correlação de Pearson (r) através do software SPSS versão 26.0, considerando significativo o valor de p<0,05. Os parâmetros de qualidade do ar MP10, O3, NO2, extrapolaram limites preconizados pelos órgãos reguladores. Em relação aos registros de internações hospitalares, foi evidenciado maior registro de internações no gênero masculino e na faixa etária dos idosos. Foi possível verificar correlação significativa entre poluentes atmosféricos e internações hospitalares, bem como nas variáveis meteorológicas.
PERCEPÇÃO DO SINTOMA FADIGA EM INDIVÍDUOS COM DIAGNÓSTICO DE ACIDENTE VASCULAR ENCEFÁLICO: ESTUDO QUALITATIVO
Authors: Gonçalves Rosa Hellen , Ribeiro Leite Tainara , Fonseca Maiara , Lopes Josiane
Published: June 2022

Introdução: A fadiga após o acidente vascular encefálico (AVE) é um sintoma muito prevalente que representa um desafio na avaliação do paciente devido ao seu caráter multidimensional e escassez de informações. Objetivo: Caracterizar o sintoma fadiga de indivíduos com diagnóstico de AVE considerando sua percepção. Métodos: Foi realizado um estudo de abordagem qualitativa, de natureza exploratória-descritiva explorando os fenômenos envolvidos na caracterização do sintoma fadiga associado ao AVE. Resultados: Participaram deste estudo 10 indivíduos com diagnóstico de AVE em que definiram a fadiga associada ao AVE como uma falta de energia caracterizada por ser transitória de acometimento diário e limitante nas atividades de vida diária e auto cuidado. A fadiga foi mais sentida em situações que exigem concentração e na tomada de decisões importantes e esteve correlacionada com ansiedade e depressão. Em sua abordagem, os participantes buscam soluções para reduzir ou cessar a fadiga configurando o fenômeno de adaptabilidade ao sintoma. Conclusão: A fadiga associada ao AVE é definida como um sintoma físico e mental, não duradouro, que causa incapacidade com repercussão sensório-motora, emocional, comportamental impulsionando os indivíduos a buscarem estratégias para conviver com a fadiga.
RECOMPONDO LAÇOS: AUTONOMIA E MATERNIDADE NEGRA NO IMEDIATO PÓS-ABOLIÇÃO EM RECIFE, 18901
Authors: Dos Santos Maria Emília Vasconcelos
Published: June 2022

O artigo analisa fragmentos de um episódio da vida da ex-cativa Gertrudes Rosário Maria da Conceição que circulou entre Pernambuco, Pará e Ceará na busca por viver a liberdade completa após 13 de maio de 1888. Utilizamos, para esse fim, um recurso de habeas corpus aberto na cidade do Recife no ano de 1890, em que localizamos uma carta, ofícios policiais e depoimentos da ex-escravizada. A trajetória de Gertrudes permite-nos discutir as disputas para garantir a autonomia, a circulação e os direitos à maternidade para mulheres negras no pós-abolição