bluuebunny/crossref_metadata_2025 huggingface dataset:
Protección por medio de patentes de invención para células madre humanas en Costa Rica
Authors: Arias Mora Freddy
Published: February 2021

This work analyzes in detail the possibility of granting protection through invention patents to human stem cells in Costa Rica. It was determined that, in the case of stem cell applications in Costa Rica, there have been multiple resolutions by the Patent Office, in some it has not been alleged that there is a patentability exception on stem cells, but in others it has been indicated that they are discoveries, that they are second uses, that they are inventions whose commercial exploitation must be prevented to protect public order, morality and the health or lives of people or animals. Also consisting of treatment methods in humans. The application of patentability exceptions contained in the Costa Rican regulations and the possibility of applying these excep-tions to stem cells are punctually analyzed. Each of the patentability requirements is analyzed to establish the possibilities and conditions that applications for stem cells should meet, so that they can be considered capable of being protected by patent in Costa Rica. It is concluded that, according to the Costa Rican legal framework, it is possible to obtained patents for stem cells from human beings.
Restricciones al derecho de uso de marcas: controversias en torno a las propuestas de etiquetado de alimentos en Colombia
Authors: Moure Pérez Juan Guillermo , Andrade Martínez Camila , Camacho Juan Carlos
Published: February 2021

Over the last decade, different proposals have emerged in Colombia and around the world re-garding food labeling conditions. The purpose of these measures has been focused on preventing non- communicable diseases (NCD), by providing clearer nutritional information to consumers regarding the food they consume on their diet. For this purpose, many proposals include the imposition of warning stamps on the label of food products that are “high in” sodium, sugar, or saturated fat, as well as other limitations on the use and marketing of the brands that identify their products.Therefore, this document aims to analyze the relevance and proportionality of the proposals in relation to the desired purposes, particularly with regard to the legitimate rights of trademark owners and consumers. In the conclusion, it will be determined that the interest in promoting regulations to reduce diseases related to poor eating habits, without an adequate evaluation of the environment in which these measures are intended to be applied, can: (i) generate undesirable and contradictory consequences with the ultimate goal of reducing diseases; (ii) impair other individual rights; and, (iii) act unjustifiably to the detriment of the industrial property rights of the trademark owners.
Modern approaches to the assessment of comorbidity in patients
Authors: Sarsenbayeva Gulzhan I. , Tursynbekova Anar E.
Published: February 2021

Aim. To provide modern data on advantages and disadvantages of available international comorbidity scales and indices. Materials and methods. Data of 29 scientific sources published in Russian and foreign literature press within 1973-2018 are considered. Results. The presence of comorbidity in a patient is an issue of modern medicine. In most cases some comorbid diseases if timely diagnosed and managed in accordance with algorithms for medical care can be corrected and treated. In order to control risks of development of complications and to prescribe an effective therapy for comorbidity the international and national clinical guidelines have been created. They include algorithms for clinical and instrumental assessment of complications and provide scales and indices, such as Cumulative lllness Rating Scale (CIRS), Charlson comorbidity index, Kaplan-Feinstein index, Index of Co-Existent Disease (ICED), Geriatric Index of Comorbidity (GIC), Functional Comorbidity Index (FCI) et al. Data of Canadian comparative study of 5 international scales of comorbidity in patients with head and neck cancers showed a significant impact of comorbidity on survival of patients with different stages of neoplasms. It was emphasized that the index of comorbidity is necessary to control an impact of comorbid diseases on the patients' status in the long-term period. The Kaplan-Feinstein scale was the best index for assessing a survival of patients with head and neck cancer. According to V.de Groot, the most widely studied comorbidity index for predicting mortality is the Charlson index. Each index has its advantages and disadvantages and is used in different clinical situations. Conclusion. General comorbidity index is a comprehensive summary score of a disease combination or severity, which combines all conditions, problems and illnesses of patients, weights them by severity, and it significantly affects treatment tactics and outcome in a future.
Magnetic resonance imaging can diagnostic early morphofunctional changes in the myocardium in young people with type 1 diabetes
Authors: Popov Kirill A. , Bondarenko Irina Z. , Biryukova Elena V. , Averkieva Elena V. , Vorontsov Alexander V.
Published: February 2021

Aim. To study the morphofunctional state of the myocardium in young people with diabetes mellitus 1 using magnetic resonance imaging (MRI) technology. Materials and methods. 38 patients (14 men, 24 women), aged 18 to 36 years old, with an experience of type 1 diabetes from 5 to 16 years old were underwent contrastive MRI of the heart. The exclusion criteria were: pronounced electrolyte disorders in the blood, dysproteinemia, chronic liver and kidney failure - glomerular filtration rate (EPI)≤60 ml/min/1.73 m2, thyroid dysfunction, obesity (body mass index ≥30 kg/m2), diagnosed cardiovascular diseases, contraindications for MRI. The indicators of functional changes in the left ventricle (circular strain, strain relaxation index - SRI), peak early diastolic strain (PSRDS) were obtained and the accumulation of the contrast agent in the delayed period were assessed. Results. The obtained results of strain, SRI, PSRDS do not allow to exclude the presence of functional changes in the myocardium of the left ventricle. In 42.11%, zones of accumulation of the contrast agent were visualized in the delayed period (insignificant - 28.95% and moderate accumulation - 13.16%), mainly by the endocardium of the cardiac apparatus (mitral and tricuspid), and in one observation (2.9%) - in combination with unexpressed diffuse heterogeneity of the myocardium of the left ventricle. Conclusion. MRI of the heart is a promising direction in the assessment of early morphofunctional changes in the structure of the myocardium, which will probably make it possible to predict life-threatening changes in the heart muscle in young patients with type 1 diabetes.
Priorities of self-monitoring of blood glucose in a treatment of diabetes mellitus
Authors: Biryukova Elena V. , Shinkin Mikhail V. , Ganekova Catherine S.
Published: February 2021

Aim. To describe a role of self-monitoring of glycemia in a treatment of diabetes mellitus (DM) and in a prevention of vascular complications of DM. Materials and methods. Data of 57 scientific sources from Russian and foreign literature published within 2005-2017 are considered. Results and conclusions. DM is a chronic disease associated with a development of micro- and macrovascular complications and to prevent them is an important task of modern medicine. In patients with DM an incidence of cardiovascular diseases is 2-3 times higher compared with the general population. Hyperglycemia is among the major damaging factors for the cardiovascular system. Clinical studies have clearly demonstrated that programs of therapeutic management of diabetic patients which include regular self-monitoring of glycemia lead to a better reduction of glycated hemoglobin levels compared to programs without self-monitoring as well as they help many patients to avoid late complications. СКГ rate is correlated with glycated hemoglobin levels. Regular self-monitoring allows you to avoid sudden and dangerous fluctuations in glycemia, including hypoglycemia, which contribute to high cardiovascular risk. The use of self-monitoring of glycemia in combination with structured patient education is associated with improving the quality of life of patients with DM. Current view on self-monitoring implies a certain frequency of blood glucose systematic measurement (varies depending on the type of glucose-lowering therapy and the degree of diabetes compensation) and is an important reference point used by both the doctor and the patient to assess a treatment outcome and to correct it if necessary. An availability of modern glucometers and skills of their correct and regular use turn a patient into an active and valuable participant in a management of DM. Achieving and maintaining the target glycemia levels depends largely on an accuracy of the glucometer since measurement results provide the basis for changing a glucose-lowering therapy if necessary. From the physician's point of view, the most important criterion for selecting a glucometer is compliance with the accuracy standards, and from the patient’s point of view this is convenience and ease of use. Thanks to improving technologies that increases an accuracy of blood glucose measurements, the procedure for self-monitoring of glycemia is simplified, which contributes to glucose-lowering therapy effectiveness and treatment compliance.
Evaluation of quality of life in elderly patients moving surgical correction of aortal valve stenosis
Authors: Molchanov Andrey N. , Romachkin Valery V. , Urvantseva Irina A.
Published: February 2021

Aim. Conduct a comparative analysis of the patient's quality of life in the long-term period after surgical correction of aortic valve stenosis after undergoing transcatheter aortic valve replacement with the results of patients undergoing aortic valve replacement with a seamless biological prosthesis under artificial blood circulation. Materials and methods. A comprehensive examination and dynamic observation in the middle and late postoperative period for 251 patients of the older age group with aortic stenosis was performed. The average age of patients at the time of treatment was 67.62±9.94 years. Group 1 included 128 patients who underwent transcatheter aortic valve replacement. In turn, Group 1 is divided into two subgroups. Subgroup A consisted of 56 patients, due to the severity of the underlying disease, concomitant pathology EuroSCORE II more than 20% and STS SCORE more than 10%. Subgroup B consisted of 72 patients with a risk of outcome of EuroSCORE II surgical intervention less than 20% and STS SCORE less than 10%. Group 2 patients (n=123) were comparable to subgroup B by the severity of the underlying disease EuroSCORE II less than 20% and STS SCORE less than 10%. All patients in group II underwent aortic valve replacement under artificial circulation.To assess the quality of life, the SF-36 questionnaire was used 12, 24, 36, 48 and 60 months after surgery. Results. The greatest increase in the total total score in the postoperative period was noted in subgroup A - 3 times (p=0.000001), and in subgroups B and group 2 was 2.66 times (p=0.0000011). By the end of the observation period, the highest total score was recorded in subgroup B, in subgroup A it was lower by 3% (p=0.95), in group 2 - by 2.4% (p=0.97). A correlation is established between the average degree between the total score, reflecting the quality of life of patients after aortic valve replacement, and the rate of ejection fraction (R=0.23, p=0.034), and the left ventricular myocardium mass (R=-0.25, p=0.028) and shock volume (R=0.29, p=0.021) according to echocardiography. Conclusions. Thus, despite a number of difficulties that were observed after surgical correction of aortic stenosis in patients of the older age group, including the presence of concomitant somatic pathology, marked cardiac changes according to echocardiography, the analysis of quality of life indicators demonstrates the positive effect of surgical treatment with a significant improvement in quality of life.
Cardiac resynchronization therapy in patients with chronic heart failure: the view of a therapist, cardiologist
Authors: Reznik Elena V. , Soltis Semen Yu. , Ustiuzhanin Dmitrii V. , Nikitin Igor G.
Published: February 2021

The prevalence of the chronic heart failure is increasing due to the success of cardiology and the increase in life expectancy of the population. A greater number of patients live up to the clinically pronounced stages of the chronic heart failure. This issue leads to an increasing in the absolute number of the patients in whom there is a lack of efficacy of optimally prescribed drug therapy. These patients are considering initiating cardiac resynchronization therapy (CRT). CRT is recommended for the patients with chronic heart failure II-IV functional class with severe left ventricular systolic dysfunction and prolonged QRS complex. Despite careful selection of patients for CRT implantation, the device does not lead to the expected result in one third of cases. To increase the effectiveness of this intervention, the procedure should be performed in accordance with current guidelines only for compliant patients who have been at least 3 months on selected optimal drug therapy, should use the optimal strategies and modes of stimulation and the adequate drug support after the intervention. The number of patients with long-term use of CRT is constantly growing. More and more patients with installed devices come into the field of vision of general practitioners and cardiologists of ambulatory clinics and hospitals, for whom it is extremely important to understand the specifics of the methods and tactics of managing such patients. This publication is dedicated to this.
Cardiovascular multimorbidity and temporary disability among health professionals of the multidisciplinary city hospital
Authors: Larina Vera N. , Glibko Kirill V. , Kasaeva Diana A.
Published: February 2021

Relevance. The article highlights the topical issues of cardiovascular mulimorbidity (CVM) and temporary disability (TD) among medical workers of a large multi-profile city clinical hospital. Aim. To assess the incidence of chronic noncommunicable diseases, CVM and TD in medical workers of the city clinical hospital. Materials and methods. 527 physicians (207 men and 320 women) aged 25 to 79 (42±9.8) years and 857 nurses (32 men and 825 women) aged 19 to 79 (41±9) years were included in a retrospective, open-label study. The medical documentations analysis was performed. Results. Hypercholesterolemia was diagnosed in 38%, overweight - in 26%, obesity - in 4.8%, smoking - in 27,2%, hypertension - in 9.1%, coronary artery disease - in 3%, diabetes mellitus - in 3.2%, CVM - in 2.3% of health care workers. Over the 3-year period, 42.3% of cases of TD were recorded. TD was associated with the female sex (OR 2.4, 95% CI 1.7-3.4; p
Acute coronary syndrome: especially treatment and rehabilitation on a stationary stage
Authors: Zolotukhin Nikolai N. , Kon’kov Aleksandr V.
Published: February 2021

Introduction to medical practice of the term «acute coronary syndrome» (ACS) showed increased interest in the problems of not only the features of the occurrence, the course of acute myocardial infarction (AMI) and unstable angina (UA), the effectiveness of treatment methods, but also the re-evaluation of the system of medical rehabilitation. Aim. To assess the features of treatment and comprehensive medical rehabilitation in AMI and UA of the Ministry of Internal Affairs of Russia (MIA), the ratio of these diseases in the structure of ACS in the treatment and rehabilitation in the Main Clinical Hospital of the MIA. Materials and methods. Over a period of 4 years treated and conducted medical rehabilitation 551 persons in the MIA, of which 152 police officer. The criterion for inclusion in the study was the presence of AMI or UA. Examination and treatment of AMI and UA was carried out in strict accordance with the approved standards. Medical rehabilitation was carried out by the method of Russian Cardiology Research and Production Complex of the Ministry of Health of the Russian Federation with the use of the dosed physical activity. Results. Of the total number of diseases, ACS was most often diagnosed in pensioners of the MIA. In the structure of the ACS, the MIA most often identifies AMI, 28-29 cases annually. The maximum frequency of the hospitalizations and 46 cases of ACS from the employees of the MIA recorded in 2015. Among pensioners of the MIA the number of ACS was maximum - 399 in comparison with employees of the MIA - 152. It should be noted that the MIA staff is dominated by AMI, pensioners - UA. For further rehabilitation, 135 patients were transferred to a rehabilitation center, most of whom were diagnosed with AMI. Transfer to the rehabilitation center for ACS for further rehabilitation was carried out up to 38% of patients with AMI and up to 4% of UA. Conclusion. The presence of the rehabilitation center in the structure of MIA allows optimal stage-by-stage medical rehabilitation of patients with ACS.
The role of single-nucleotide polymorphism rs10824026 of the SYNPO2L gene in the development of atrial fibrillation in a study in the East-Siberian population
Authors: Shishkova Kseniia Yu. , Nikulina Svetlana Yu. , Shulman Vladimir A. , Chernova Anna A. , Maksimov Vladimir N. , Gurazheva Anna A.
Published: February 2021

Background. Atrial fibrillation (AF) is the most common type of heart rhythm disturbance, leading to the development of lifethreatening conditions, such as cardio embolism, heart failure, and even sudden cardiac death. In recent years, the genetic aspects of AF have been actively discussed. The largest number of genetic predictors of AF was identified after a full genome-wide association studies (GWAS). Given that so far no studies of the association of rs10824026 polymorphism of chromosome 10q22 with the development of AF have been conducted in the Russian population, we conducted this clinical study. Aim. Checking the associations of the development of AF with the single-nucleotide polymorphism rs10824026 of the SYNPO2L gene in the East-Siberian population. Materials and methods. The study design was formed in accordance with the National Standard of the Russian Federation Good Clinical Practice, GOST P 52379-2005. The study uses design - “case-control”. The main group of patients - patients with known cardiac arrhythmias by the type of AF (n=106, average age 57.0±9 years, men 49.4%, women 50.6%), the group was formed using the criteria of the World Health Organization and the European Society of cardiologists. The control group (n=105, average age 57.0±9 years, men - 50.0%, women - 50.0%) was selected by age and gender from the DNA bank of international studies MONICA (Multinational MONItoring of trends and determinants in cardiovascular disease) under a joint agreement with the Research Institute of Therapy and preventive medicine - Novosibirsk. DNA was isolated by phenol-chloroform extraction. Among other things, among the research methods, routine laboratory methods were used; instrumental data; and invasive tactics such as CAG. Results. As a result of clinical genetic testing, it was found that the frequency of G/G polymorphism of the SYNPO2L gene in patients with AF shows a statistically significant difference.
Heart lesions in individuals with arterial hypertension of various risk levels: the possibility of diagnosis and treatment
Authors: Britov Anatolii N. , Platonova Elena M. , Eliseeva Nina A.
Published: February 2021

Based on scientific literature and own data, the article discusses the problem of hypertensive heart disease in real outpatient practice and especially in conducting preventive examinations in the working population. It is shown that the use of modern diagnostic methods, in particular electrocardiography with dopplerography, including pulse-wave tissue mode, should be an integral study included in the professional examination, as well as medical examination, which covers an increasing number of the population of our country. Echocardiography should be performed to clarify the cardiovascular risk and confirm the electrocardiographic diagnosis of left ventricular hypertrophy (LVH), left atrial dilatation, or suspected heart diseases (coronary heart disease, atrial fibrillation, other rhythm disorders). It has been shown that concentric LVH is the strongest predictor of an increased risk of heart failure, although the degree of LVH is not always directly related to the degree of hypertension and the duration of the disease.
Telemetric electrocardiography in diagnostics of cardiotoxic heart rhythm disorders and conductivity in oncologic patients
Authors: Lyamina Nadezhda P. , Pogonchenkova Irena V. , Lyamina Svetlana V.
Published: February 2021

Aim.Assessment of the possibility to use ECG-telemetry in order to increase the efficiency of cardiotoxic effect diagnosis in cancer patients with chemotherapy.

Material and methods.Remote dynamic monitoring for 6 months was carried out in 31 cardio-oncological patients (in 17 prostate cancer (PC), in 14 breast cancer (BC), mean age was 53.6 (50.1; 56.8) years and 48.3 (38.8; 57.1) years, respectively; FC NYHA IIII; left ventricular ejection fraction 47.4% (40.2; 57.3) and 43.2% (39.7; 58.9), respectively; Mini-Mental State Examination from 30 to 24 points 27.6 (25.4; 29,1) and 28.2 (25.1; 28.8), respectively. ECG-telemetry was performed according to the principle of auto-translation using individual ECG recorders, mobile devices and the ECG Dongle Internet application (Nordavind-Dubna, Russia). Storage, analysis of information and telemedicine consultation was perfomed with the CardioСloud asynchronous tele-cardiological platform. ECG was registered with a frequency of at least 5 times/day and additionally repeatedly in the presence of symptoms and patient desires, duration 1020 minutes.

Results.Previously undocumented ECG changes were remotely recorded in patients for 6 months of follow-up: in 87.0% of patients sinus tachycardia, against which ventricular extrasystole of various gradations (32.3%), supraventricular extrasystole (22.6%), transient tachy-dependent blockade of the bundle of His legs were recorded (9.7%). In 64.7% of PC patients and in 42.8% of BC patients rhythm disturbances were detected in combination with depression of theSTsegment. Paroxysms of atrial fibrillation were reported in 17.6% of PC patients and in 14.3% BC patients. In 35.5% of patients the detected ECG changes were asymptomatic.

Conclusion.Remote dynamic monitoring in cancer patients receiving chemotherapy involving ECG recording scheme (5 times/day, 1020 min) with ECG telemetry is an effective and unexpensive method for detecting ECG changes in the phenomenon of cardiotoxicity.
A clinical case of takotsubo syndrome in combination with left ventricular hypertrabeculation
Authors: Boldueva Svetlana A. , Evdokimov Dmitrii S. , Evdokimova Larisa S. , Khomulo Arina D.
Published: February 2021

The article describes the clinical case of takotsubo syndrome in female, who has also echocardiographic picture of a left ventricular noncompaction cardiomyopathy. According to the result of magnetic resonance imaging, the diagnosis of noncompaction cardiomyopathy was not confirmed, left ventricular hypertrabeculation was revealed. There are single descriptions of the combination of takotsubo syndrome and left ventricular hypertrabeculation, the pathogenetic relationship of these conditions has not yet been established.
Assessment of the effect of -blockers on the functional state in patients with ventricular arrhythmias: results of a comparative study
Authors: Shubitidze Iosif Z. , Tregubov Vitalii G.
Published: February 2021

Aim.Compare the effects of bisoprolol, nebivolol and sotalol on the functional state of patients with ventricular arrhythmias (VA).
Material and methods.120 patients with VA against the background of essential hypertension or its combination with coronary heart disease took part in the research, they were randomized into three groups for treatment with bisoprolol, nebivolol and sotalol. As part of combination therapy, patients were administered lisinopril, and if indicated, acetylsalicylic acid, atorvastatin. Initially and after 24 weeks of therapy the following was done: echocardiography, treadmill test, six-minute walk test, subjective assessment of quality of life, all-day monitoring of blood pressure and electrocardiogram.
Results.With comparable hypotensive and antiarrhythmic effects, therapy with nebivolol increased exercise tolerance to a greater extent, in comparison with bisoprolol and sotalol. Nebivolol and sotalol improved the quality of life, in comparison with bisoprolol.
Conclusion.In patients with VA against the background of essential hypertension or its combination with coronary heart disease as part of combination therapy the use of nebivolol may be preferable to bisoprolol or sotalol due to a more pronounced positive effect on the functional state.
Association of polymorphism -1171 5A/6A of the matrix metalloproteinase gene type 3 (rs35068180) with dilated cardiomyopathy
Authors: Kuznetsova Oxana O. , Nikulina Svetlana Yu. , Chernova Anna A. , Maksimov Vladimir N.
Published: February 2021

The paper describes the investigation of matrix metalloproteinase type 3 (MMP-3) -1171 5A/6A gene polymorphic alleles variants (rs35068180) in patients with dilated cardiomyopathy. A allele and 6А6А genotype of MMP-3 -1171 5A/6A gene (rs35068180) were determined as new genetic predictors of dilated cardiomyopathy development.

Aim. To study the association of polymorphism -1171 5A/ of the MMP-3 gene with dilated cardiomyopathy of various origins.

Material and methods. The main study group comprised 221 patients with dilated cardiomyopathy (DCM) of different origin. Their average age was 55.309.69 years. Among them there were 111 persons with DCM of ischemic origin, including 99 (89.2%) men and 12 (10.8%) women. The average age of the subjects with DCM was 51.739.74 years, the age of the male subgroup was 51.008.96 years, and the age of the female subgroup was 57.753.71 years. A total of 110 patients with idiopathic cardiomyopathy were included in the study. Among 221 patients, 110 persons did not demonstrated idiopathic dilated cardiomyopathy as the cause of myocardium dilation. This group comprised 100 (91.5%) male patients and 10 (8.5%) female patients. The control group of subjects (221 persons) was represented by healthy people without diseases of the cardiovascular system. The average age of control subjects was 53.64.8 years. We examined all patients in the main group using routine laboratory and instrumental methods, as well as coronary angiography. If myocarditis was suspected, we did an MRI of the heart. Genotyping of polymorphism -1171 5A/6A (rs35068180) of the MMP-3 gene was performed using PCR.

Results. Among patients of the main group with dilated myocardial remodeling of various Genesis, the allele was documented in 65.8% of cases against 59.3% among the control group, p=0.044. The homozygous genotype of the MMP-3 gene in patients of the main group was verified in 42.1% of patients against 32.6% of cases in relatively healthy individuals (p=0.099).

Conclusion. We have proved the predominance of 6A allele and 6А6А genotype of the MMP-3 gene in the group of patients with DCM. It seems that it is homozygous 6A allele that causes a decrease in the activity of the transcription process and change in the level of stromelysin in arterial walls. This contributes to the activation of type 1 procollagenase, extracellular matrix deposition and cardiac muscle remodeling.
Treatment of patients with acute coronary syndrome in real clinical practice in the Republic of Karelia: 10-years registry results
Authors: Skopets Inga S. , Vezikova Natalia N. , Karapetian Tamazi D. , Malafeev Andrew V. , Malygin Aleksandr N. , Litvinova Violetta A.
Published: February 2021

Aim. To present the treatment of Acute coronary syndrome (ACS) in clinical practice in the Republic of Karelia and the results of Cardiovascular centers working.
Material and methods. The prospective study included 9949 patients successively hospitalized from 01.01.2020 to 01.01.2020 in the Regional cardiovascular center (Petrozavodsk, Russia), 6335 were included in Federal register. Risk factors, clinical features, reperfusion strategy as well as the rate of clinical complications, drug therapy and outcomes were assessed.
Results. 9949 patients were treated in Regional cardiovascular center from 01.01.2010 to 01.01.2020 due to acute coronary syndrome, and 6335 were included to the Federal registry. 40.2% of patients had ST-elevation Myocardial Infarction and 59.8% ACS without ST elevation. The first group was younger (the average age was 69) than the second (the average age was 74). The drug therapy of ACS in the hospital was following: 98.7% of patients took aspirin; b-blockers 92.3%, statins 97.4%. The outcomes of ACS during the hospital discharge were following: Q-wave myocardial infarction (MI) was diagnosed in 34.2% cases, non-Q-wave MI in 23.4%, unstable angina 20.5%, repeated MI 18.7% and 2.5% MI unspecified localization.
The analysis of the clinical features of ACS shows that significant number of patients (24.8%) had severe complications. So, ventricle arrhythmias were diagnosed in 17.3% of cases, acute left ventricle insufficiency in 7.6%, cardiogenic shock in 3.0%, cardiac arrest in 1.9%, myocardial rupture in 0.4%. The hospital mortality rate reached 6.38%.
Conclusion. The article presents data about treatment of patients with acute coronary syndrome in real clinical practice in the Republic of Karelia based on 10-years register. Difficulties of management and reperfusion interventions, the volume of drug therapy, the frequency of complications, as well as outcomes and hospital mortality are discussed. The presented data show the results of modernization of the medical care program for patients with acute coronary syndrome in practical healthcare in the region.
Concepciones docentes sobre la interculturalidad en la Nueva Escuela Mexicana
Authors: Tiburcio Celestina , Jiménez Lobatos Violeta Denis
Published: February 2021

Las políticas educativas poseen rasgos según sea el gobierno que las promueva. Tal es el caso en México de la implementación de la Nueva Escuela Mexicana (NEM) que, fundamentada en humanismo social, busca impactar en los espacios educativos y renovar las prácticas. Pero, después de una década de reformas donde imperaron enfoques sobre educación bicultural, intercultural e inclusiva, los profesores vuelven a ser receptores de discursos que deben apropiar y retomar en sus prácticas didácticas. Por ello, esta investigación analiza las concepciones sobre interculturalidad de seis profesoras de nivel básico (preescolar, primaria y secundaria), a través de una metodología cualitativa y retomando algunos rasgos de la autoetnografía. Se concluye que conceptualizar y trabajar didácticamente la diversidad, desde el enfoque intercultural, aún requiere trascender de perspectivas relacional o funcional  (Walsh, 2011) para llegar a una visión crítica que dialogue con los principios de la NEM.
Diversidade, arbitrários e trânsitos: memorial acadêmico
Authors: Gontijo Fabiano
Published: February 2021

Trata-se do memorial acadêmico apresentado como requisito para a progressão funcional para Professor Titular da Universidade Federal do Pará (UFPA). O memorial foi defendido publicamente com êxito no dia 4 de dezembro de 2019, diante da banca examinadora composta pelas/os Professoras/es Doutoras/es Rosa Elizabeth Acevedo Marín, (Presidenta), da UFPA, Carlos Alberto Caroso Soares, da Universidade Federal da Bahia (UFBA), Russel Parry Scott, da Universidade Federal de Pernambuco (UFPE), Antônio Carlos Mota de Lima, também da UFPE, Lina Maria Brandão de Aras, da UFBA, e Leila Mourão Miranda, da UFPA. O memorial apresenta as principais atividades de pesquisa, extensão e docência desenvolvidas por mim ao longo das últimas três décadas, com ênfase especial para a atuação junto às Universidades Federais do Piauí e do Pará.
Alunes trans e professores cis: etnografia, diferença e diversidade no escopo da educação popular
Authors: Oliveira Lima Alef de
Published: February 2021

A cisgeneridade, assim como qualquer outra categoria de gênero possibilita certas experiências sociais e também inviabiliza outras. A questão que ela remete esboça uma certa relação com os sistemas sexo-gênero das sociedades “ocidentais”. O presente artigo se apoia em um modo crítico de pensar a vivência da docência de professores e professoras cisgêneros, dentro de um Coletivo Político que desempenha uma ação de Educação Popular centrada em alunes Trans, localizado na cidade de Porto Alegre/RS. Para tanto, visa indagar o lugar da diversidade no escopo da prática pedagógica, situá-la enquanto uma problemática ética que perfaz aspectos sutis, mas extremamente importantes no reconhecimento social da população Trans. O ponto de partida do texto é ancorado em uma abordagem etnográfica e se utiliza da observação-participante no interior do funcionamento do Coletivo e do exame de algumas percepções do corpo discente Trans sobre as condutas e sentimentos gerados no contato com professorado cis.
Qualitative Study: The Organizational Management for Academic Character Building of the AKBARA Polytechnic of Surakarta Member
Authors: Wahyuono Titis , Wuryanto Tri , Syarifah
Published: February 2021

Various facts and phenomena of human moral degradation in higher education both lecturers, college students, and managers have occurred over time because of the rapid mordenization (Setiawati, 2012). Therefore, researchers are interested to know the qualitative study to find out how the social phenomenon in collage today so that it will bring up important points in the effort to create and build the character of college students. The approach used in this research is qualitative approach. The population in this study is the entire staff of AKBARA Surakarta Polytechnic. The sample in this study was 32 respondents using total sampling techniques. Research data is the main data by conducting interviews to all staff of AKBARA Surakarta Polytechnic. Then a scientific study was carried out from the source of the library which eventually obtained conclusions from problem solving about the research carried out. Data analysis techniques used are qualitative study research phenomena. The results showed that the characteristics of respondents as the highest sex in women was 51.5%, seen in terms of age in the age range 21-35 year olds with a percentage of 75%, and post-graduate education with a percentage of 48.5%. It is crucial to get a character education. This aims to strengthen morals and praiseworthy qualities for college students (in this case, college students) because intelligence in education is not enough without strong moral and character provisions. This is where the importance of character education. An attitude of empathy is one of the character qualities that can change the world. Polytechnic AKBARA concern about those activities in building the student's character. The management initiated the CAKRA Akbara, which consists of Competent, Toughness, and Character.
The Influence of Future Cash Flow Predictions on Profits in Companies Listed on the Indonesia Stock Exchange
Authors: Purwanti Titik
Published: February 2021

This research was conducted to determine the effect of future cash flow predictions on profits (gross profit, operating profit, and net income) in food and beverage companies listed on the Indonesia Stock Exchange. The method used in this research used purposive sampling with a population of food and beverage companies listed on the Indonesia Stock Exchange for the period 2016-2018. The samples in this research were 19 companies. The results obtained indicate that the operating profit variable has a partial effect on future cash flows, while the net income variable and the gross profit variable do not partially affect future cash flows. Simultaneously, gross profit, operating profit and net income have an effect on future cash flows.
DESIGN AND DEVELOPMENT OF LOW COST SMART BILLING SYSTEM
Authors: K Prakruthi , B Sowmya , B Kiran , K N Manjunatha
Published: February 2021

This paper presents the design of smart billing systems which can be placed to reduce the huge crowd in the malls in towns and cities. Especially it becomes more crowded on holidays. Customers pick different items in the malls and put them into trolley. At the cash counter billing process is done using bar code scanner and it is very time consuming process. To avoid this we are developing a system which we called as “Smart Billing System Using RFID and ZIGBEE”. In this system we are using RFID tags instead of barcodes. This RFID tag will be on the products. Whenever the customer puts a product into the trolley it will get scanned by RFID reader and product name and cost will be displayed on visual display. Like this the process goes on. We are using ZIGBEE transceiver which will be on the trolley which is used to transfer data to main computer. At the main computer ZIGBEE transceiver will be placed which will receive data from transmitter. To store the products price and total billing controller memory is used. Product name and the total cost will be displayed on LCD.
UNDERLYING FACTORS AFFECTING UTILIZATION OF COMPUTER – BASED INTERNET TECHNOLOGIES BY AGRICULTURAL EXTENSION PERSONNEL IN AKWA IBOM, NIGER DELTA, NIGERIA
Authors: AKPABIO Iniobong Aniefiok , EDET Glory Emmanuel , CYRIL Joan Ekpo
Published: February 2021

The study sought to examine factors affecting utilization of Computer Based Internet Technologies (CBIT) by extension personnel in Akwa Ibom State, Nigeria. Relevant data were obtained from 180 respondents, while data analyses were achieved with the aid of descriptive and inferential statistical tools. Findings showed that 57.8 % of the respondents were male, 91.7% were married, with a mean age of 43years, while 62.8% respondents had no formal computer training. It was also revealed that, of the nine surveyed CBIT facilities and applications, only mobile phones were highly utilized, while I-pads/laptops and YouTube were the least utilized. It was also revealed that 62.8% respondents indicated that they had a low level of CBIT utilization, while level of CBIT utilisation was found to be influenced by financial, training, policy/personal barriers, social, technical and management factors. Results of tested hypotheses revealed that CBIT utilisation was not influenced by respondents’ personal characteristics, and no significant difference was observed in terms of level of CBIT utilization between field extension personnel (FEP) and supervisory extension personnel (SEP). It was concluded that extension personnel are constrained from using CBIT due to the prohibitive cost of CBIT software and maintenance, inappropriate infrastructure and lack of access to training opportunities. It is recommended, among others, that policy makers should facilitate the evolution of appropriate CBIT policies to enhance access to appropriate tools by extension personnel.
Uma entrevista com Dawid Surmik: pesquisa e ensino da Paleontologia Molecular
Authors: Alves Everton Fernando
Published: February 2021

Esta entrevista foi realizada com o tafônomo molecular polonês Dawid Surmik, um dos maiores especialistas em Paleontologia Molecular da atualidade. Surmik nos conta sobre os desafios que despertaram o seu interesse pelo estudo da Paleobiologia de tetrápodes marinhos e terrestres do Mesozóico por meio da aplicação de técnicas inovadoras de detecção de biomoléculas antigas. Na primeira parte da entrevista, Surmik explica o que é a Paleontologia Molecular, os objetos de estudo, a importância das pesquisas paleomoleculares e as principais técnicas utilizadas em suas investigações. Na segunda parte da entrevista, Surmik apresenta a forma como a Paleontologia Molecular pode ser ensinada para níveis básicos da educação, como no caso do Ensino Fundamental e Médio, e para o Ensino Superior em nível de graduação em Ciências Biológicas. Na última parte, Surmik explora brevemente as possíveis abordagens de investigação da Paleontologia Molecular a partir da perspectiva da Educação em Ciências.

Palavras chave: Ensino de Paleobiologia, Tafonomia Molecular, biomoléculas antigas, educação em ciências.
»Der Psychiater meiner Mutter sagt, bei Demenz hilft keine Psychotherapie«
Authors: Wächtler Claus
Published: February 2021

Kognitive Beeinträchtigungen sind bei der Depression älterer Menschen häufig, sie stellen bei der Demenz (vom Alzheimertyp) das Hauptsymptom dar. Kognitive Störungen bei Depression und Demenz zeigen einige Unterschiede. Ältere Menschen mit kognitiver Beeinträchtigung haben Schwierigkeiten bei der Alltagsbewältigung. Kognitive Störungen verschlechtern den Respons auf therapeutische Maßnahmen speziell bei der Depression. Allerdings kann Psychotherapie auch bei kognitiver Beeinträchtigung wirksam sein, sofern Modifikationen berücksichtigt werden und bei körperlicher Komorbidität eine Kooperation mit dem Hausarzt erfolgt.
“Maybe You Should Try It This Way Instead”: Youth Activism Amid Managerialist Subterfuge
Authors: Clay Kevin L. , Turner David C.
Published: February 2021

The authors theorize what we call managerialist subterfuge, drawing on distinct ethnographic studies to examine how adult “partners” leverage the language and strategies of corporate managerialism to undermine youths’ radical visions of change. Critical analysis of patterns in interview and participant observation data across two youth participatory action research projects revealed the ways in which adult interventions functioned to co-opt youths’ activist agendas; following the rationale that youth who are presumed to be in need of adult management are “out of their depth” when it comes to civic matters. The authors assert that managerialist subterfuge functions as a mechanism to further bureaucratize youth activism and absolve state actors of accountability for harm that Black youth and youth of color experience.
Generation Interrupted: Rethinking “Students with Interrupted Formal Education” (SIFE) in the Wake of a Pandemic
Authors: Chang-Bacon Chris K.
Published: February 2021

The COVID-19 pandemic disrupted schooling worldwide, compelling educators, researchers, and policymakers to grapple with the implications of these interruptions. However, while the scale of these disruptions may be unprecedented, for many students, interrupted schooling is not a new phenomenon. In this article, I draw insights from the field of Students with Interrupted Formal Education (SIFE) for supporting students who experience schooling interruption. In addition, I argue that the extensive accommodations offered to students in the midst of the pandemic must be preserved for future generations of SIFE students—a population for whom similar accommodations have been historically denied. Through this analysis, I demonstrate the need to interrogate traditional notions of interrupted schooling and the students who experience it. This article offers implications for rethinking interrupted schooling, as well as formal education writ large, toward more equitable and socially just ends.
Career selection of students using hybridized distance measure based on picture fuzzy set and rough set theory
Authors:   School of Computer Engineering, KIIT University, Bhubaneswar, India, Sahu Rekha , Dash Satya R. ,   School of Computer Engineering, KIIT University, Bhubaneswar, India, Das Sujit ,   Department of Computer Science and Engineering, National Institute of Technology Warangal, Warangal, India
Published: February 2021

Since the future of the society depends upon the role of students, so suitable career selection methods for the students are considered to be an important problem to explore. It is assumed that if a student has the required capability and positive attitudes towards a subject, then the student will achieve more in that subject. To consider the uncertain issues involved with students’ career selection, picture fuzzy set (PFS) and rough set based approaches are proposed in this study as they are found to be appropriate due to their inherent characteristics to deal with incomplete and imprecise information. For the purpose of selecting a suitable career, the article analyzes student's features in terms of career, memory, interest, knowledge, environment and attitude. We propose two hybridized distance measures using Hausdorff, Hamming and Euclidian distances under picture fuzzy environment where the evaluating information regarding students, subjects and student's features are given in picture fuzzy numbers. Then we present an algorithmic approach using the proposed distance measures and rough set theory. We apply rough set theory to determine whether a particular subject is suitable for a student even if there is controversy to select a stream. Lower and higher approximation with boundary region of rough set theory is used to manage the inconsistent situations. Finally, two case studies are demonstrated to validate the applicability of the proposed idea.
Korelasi Praktik Entrepreneurship Terhadap Kemandirian Gereja IFGF di Flores Jemaat Maumere
Authors: Ngaji Paulis , Laukapitang Yunus D. A.
Published: February 2021

Adapun tujuan dari penulisan skripsi ini ialah: untuk menjelaskan bentuk-bentuk praktik-praktikentrepreneurship yang dijalankan oleh gereja IFGF Maumere dan untuk mengetahui korelasi praktik-praktikentrepreneurship terhadap kemandirian gereja IFGF Maumere. Metode penelitian yang digunakan dalamkarya ilmiah ini merupakan metode penelitian kuantitatif dengan teknik pengumpulan data adalah sebagaiberikut pertama penulis melakukan studi kepustaka yaitu penulis membaca dan mengumpulkan data-data daribuku-buku, jurnal dan artikel yang berhubungan dengan judul sebagai dukungan dalam menyusun skripsi.kedua melakukan obserfasi secara langsung untuk mengamati dan membagikan angket serta melakukanwawancara yang dibagikan kepada kepala keluarga yang merupakan anggota jemaat aktif yang terdaftar digereja IFGF Maumere, dengan tujuan untuk mendapatkan data yang akurat dalam mengetahui sejauh manakorelasi praktek entrepreneurship terhadap kemandirian gereja IFGF di Flores jemaat Maumere. kesimpulandan saran-saran dalam penulisan ini adalah sebagai berikut: pertama praktek entrepreneurship adalah usahayang dikembangkan mulai dari untuk bertahan hidup samapai untuk membiayai kehidupan dan orang laindalam meningkatkan ekonomi. Kedua mengenai kemandirian gereja yang merupakan gereja berdiri secaraotonom untuk mengelolah dan membiayai semua kegiatan gereja.
Chương trình quốc tế ISME thông báo
Authors: AISDL
Published: February 2021

Nhân dịp đoàn NCS đến từ trường ĐHTH Ling Tung, Đài Loan sang thăm và giao lưu với cán bộ giáo viên và sinh viên Viện ĐTQT, Viện tổ chức buổi gặp gỡ với đoàn kết hợp trao đổi khoa học.
Kajian Biblika Tentang Berpuasa Berdasarkan Yesaya 58:1-12 Dan Implikasinya Bagi Orang Percaya Masa Kini
Authors: Mensis Reza , Laukapitang Yunus D. A.
Published: February 2021

Tujuan penulisan skripsi ini adalah menjelaskan secara Alkitabiah tentang konsep berpuasaberdasarkan Yesaya 58:1-12. Adapun metode yang digunakan oleh penulis adalah metodekualitatif yaitu metode penelitian kepustakaan yaitu membaca buku-buku yang relevan,tafsiran-tafsiran dan menyelidiki kitab yang berkaitan dengan pembahasan konsepberpuasa dalam kitab Yesaya 58:1-12. Selain itu penulis juga menggunakan analisiskonteks, analisis struktur, dan analisis teks dengan mencari makna dari setiap kata-katapenting dalam nas. Dari hasil penelitian ini maka penulis menarik beberapa kesimpulan.Pertama, Nabi Yesaya diperintahkan Allah untuk mengecam dan menegur setiap kesalahanyang bangsa Israel perbuat semasa mereka menjalankan ibadah puasa mereka. Kedua,berpuasa merupakan sikap respons orang percaya dalam mereka merendahkan diri danmeninggalkan hal-hal keduniawian. Ketiga, dalam menjalankan ibadah puasa harus sesuaidengan apa yang Allah kehendaki. Berpuasa juga merupakan salah satu disiplin rohanikepada Allah. Dalam menjalankan kegiatan puasa seseorang harus membawa damaisejahtera dan melayani orang lain. Berpuasa juga meningkatkan kesalehan individualseseorang dan kesalehan sosial seseorang.Kata-kata Kunci: Bangsa Israel, Berpuasa, Orang Perc