bluuebunny/crossref_metadata_2025 huggingface dataset:
The constituents of trust in the context of a return to work following a work disability: A scoping review protocol
Authors: Tamokoue Hermann Brice Tegninko , Gouin Marie-Michelle
Published: November 2022

Background: Long-term work disability due to a musculoskeletal disorder (MSK) or a common mental disorder (CMD) is a serious issue that affects the whole of society. Facilitating relationships between the multiple stakeholders involved in someone’s return to work (RTW) has emerged as a key avenue for a successful RTW and must include building trust between stakeholders. Although the constituents of trust have been identified in previous social science and business studies, no review has yet documented which have been explored in the context of RTW.
Methods: We will conduct a scoping review using Peters and coll.’s methodology and the PRISMA-P methodology to identify the constituents of trust that have been explored in the context of RTW following a work disability due to a MSK or a CMD. Full-text studies in English and French will be retrieved from the following databases: PsycINFO, CINAHL, ABI/INFORM, Business Source Complete, Scopus, and PubMed. The authors will extract, chart, categorize and summarize the data in the papers selected.
Discussion: The results will be used to develop a tool for building trust between RTW stakeholders. More specifically, the operationalization of trust will be discussed in an expert consensus group on how to build trust between stakeholders and in turn facilitate the RTW.
Systematic review registration: PROSPERO does not register scoping reviews.
Real-World Data on the Incidence and Risk of Guillain-Barre Syndrome Following SARS-CoV-2 Vaccination: A Prospective Surveillance Study
Authors: Ha Jongmok , Park Suyeon , Kang Hyunwook , Kyung Taeeun , Kim Namoh , Kim Dong Kyu , Kim Hyeonjoon , Bae Kihoon , Song Min Cheol , Lee Kwang June , Lee Euiho , Hwang Beom Seuk , Youn Jinyoung , Seok Jin Myoung , Park Kunhee
Published: November 2022

Increasing evidence suggests an association between SARS-CoV-2 vaccines and Guillain-Barré syndrome (GBS). Nevertheless, little is understood about the contributing risk factors and clinical characteristics of GBS post SARS-CoV-2 vaccination. In this prospective surveillance study of 38,828,692 SARS-CoV-2 vaccine doses administered from February 2021 to March 2022 in the Gyeonggi Province, South Korea, 55 cases of GBS were reported post vaccination. We estimated the incidence rate of GBS per million doses and the incidence rate ratio for the vaccine dose, mechanism, age, and sex. Additionally, we compared the clinical characteristics of GBS following mRNA-based and viral vector-based vaccinations. The overall incidence of GBS following SARS-CoV-2 vaccination was 1.42 per million doses. Viral vector-based vaccines were associated with a higher risk of GBS. Men were more likely to develop GBS than women. The third dose of vaccine was associated with a lower risk of developing GBS. Classic sensorimotor and pure motor subtypes were the predominant clinical subtypes, and demyelinating type was the predominant electrodiagnostic subtype. The initial dose of viral-vector based vaccine and later doses of mRNA-based vaccine were associated with GBS, respectively. GBS following SARS-CoV-2 vaccination may not be clinically distinct. However, physicians should pay close attention to the classic presentation of GBS in men receiving an initial dose of viral vector-based SARS-CoV-2 vaccines.
Subcuticular suture and incisional surgical-site infection in elective hepatobiliary and pancreatic surgery: an open-label, pragmatic randomized clinical trial (CLOSKIN trial)
Authors: Aguirre-Allende Ignacio , Alkorta-Zuloaga Maialen , Iglesias-Gaspar Maria Teresa , Urreta-Ballobre Iratxe , García-Domínguez Amaia , Arteaga-Martin Xabier , Beguiristain-Gómez Adolfo , Medrano-Gómez Miguel Ángel , Ruiz-Montesinos Inmaculada , Riverola-Aso Ana Paula , Jiménez-Agüero Raúl , Enríquez-Navascués José María
Published: November 2022

Background: subcuticular suture has proven to reduce superficial incisional SSI (si-SSI) in clean surgery. However, question remains regarding clean-contaminated procedures. The aim of this study is to assess that subcuticular suture is superior to staples in reducing si-SSI incidence in elective HBP surgery.
Methods: single-centre, open-label, parallel, pragmatic randomized clinical trial conducted at a referral tertiary Hospital between January 2020 and April 2022. Patients eligible for elective HBP surgery were randomly assigned (1:1) to subcuticular suture or surgical staples wound closure using a minimisation method based on previously confirmed risk factors. The primary endpoint was the incidence of si-SSI. Considered secondary endpoints were major postoperative morbidity in both groups, additional wound complications, median hospital length of stay and need for re-hospitalisation.
Results: Of the 379 patients, 346 patients were randomly assigned to receive skin closure with staples (n= 173) or subcuticular suture (n= 173). After exclusion of 11 participants, 167 and 168 patients respectively in the control and the experimental group received their allocated intervention. For the primary endpoint, no significant differences in si-SSI rate were found: 17 (9.82%) staples group vs. 8 (4.62%) in subcuticular suture group (p= 0.062). Subset analysis confirmed absence of significant differences. As for secondary endpoints, overall wound complications did not differ significantly between two procedures: 19 (10.98%) vs. 10 (6.35%) (p= 0.127). There were no treatment related adverse events. However, occurrence of si-SSI contributed to major postoperative morbidity in both groups (p< 0.001 and p= 0.018) and to a substantially prolonged postoperative hospitalization (p= 0.015).
Conclusions: subcuticular suture might offer a relative benefit for skin closure reducing incidence of si-SSI after elective HBP surgery, although this was found not to be clinically relevant. Yet, this should not be interpreted as equivalence among both treatments. Therefore, wound closure strategy should not be based only on these grounds.
Trial registration number: ISRCTN Registry number ISRCTN37315612 (registration date: 14/01/2020)
Single cell RNA sequencing reveals C5aR1 inhibition to selectively target pro-tumorigenic M2 macrophages reversing PARP inhibitor resistance
Authors: Li Xi , Poire Alfonso , Jeong Kang Jin , Zhang Dong , Ozmen Tugba , Chen Gang , Sun Chaoyang , Mills Gordon
Published: November 2022

Although Poly (ADP-ribose) polymerase (PARP) inhibitors (PARPi) have been approved in multiple diseases, including BRCA1/2 mutant breast cancer, responses are usually transient thus requiring the deployment of combination therapies that can prevent or reverse PARPi resistance. We thus explored mechanisms underlying sensitivity and resistance to PARPi using two intrinsically sensitive and resistant syngeneic murine breast cancer models. Our data indicate that the PARPi-sensitive tumor model has a high ratio of M1 anti-tumor/M2 pro-tumor macrophages with the M1/M2 ratio being increased by PARPi. In contrast the PARPi-resistant tumor model had very low levels of M1 macrophages and thus a low M1/M2 ratio that was not altered by PARPi. Transplantation of the PARPi-sensitive and the PARPi-resistant tumor in opposite mammary fat pads results in accumulation of M2 macrophages in the sensitive tumor, rendering the sensitive tumor PARPi resistant suggesting that transit of M2 macrophages could contribute to resistance across distant sites both within and between tumors. C5ar1 and Rps19/C5ar1 signaling are selectively elevated in the M2 macrophages that are associated with PARPi resistance. Indeed, C5aR1 positive cells were sufficient to transfer resistance to PARPi. Strikingly targeting C5aR1 decreased M2 macrophage numbers, while sparing M1 macrophages rendering PARPi-resistant tumors sensitive to PARPi in a CD8 T cell dependent manner. Consistent with the murine data, high C5aR1 levels in human breast cancers are associated with a poor response to immune checkpoint blockade. Thus, targeting C5aR1 may represent an approach to selectively deplete M2 macrophages and engender sensitivity to PARPi and potentially other therapies.
Abscisic acid increases the viability of cryopreserved shoot tips of Lilium pumilum by regulating the osmotic stress and programmed cell death
Authors: Wang Qi , Zhu Mengting , Zhang Lingling , Liu Yan
Published: November 2022

Lilium pumilum plays an important role in lilium resistance breeding because of its wide distribution and strong stress resistance. It is of great significance to establish an efficient cryopreservation procedure for Lilium pumilum. In this study, the cryopreservation protocol of Lilium pumilum shoot tips by vitrification was established as follows: The 2 months old tissue-culture plants, which outer scales of small bulbs at the base of small plants were removed and only the 1–2 layers scales that encasing the shoot tips were retained were precultured on Murashige Skoog medium (MS) with 0.5M sucrose and 25µM abscisic acid(ABA) for 7 days at 4℃ in the dark; Then, the 2 mm shoot tips were gain under stereoscopic microscope in an ultra-clean workbench, and 10 shoot tips were put into a 1.5ml frozen centrifuge tube and added 1ml Loading solution (MS + 0.4M sucrose + 2M glycerin) for 20min at 25°C; then the Loading solution was removed, precooled PVS2 solution (MS + 0.4M sucrose + 30% glycerol + 15% ethylene glycol + 15%DMSO) was added for 80min at 0℃; The tube was plunged into liquid nitrogen and keeping. When it was needed, the tube was removed from the liquid nitrogen tank, and rapidly thawed in 37 ℃ water bath for 60s; After that, PVS2 solution was removed and shoot tips were washed twice for 10 min each time with unloading solution (MS + 1.2M sucrose) at 25 ℃. Subsequently, the shoot tips were incubated on medium (MS + 30 g·L− 1 sucrose + 6.5 g·L− 1 agar) for regeneration. With this procedure, the shoot tips survival rate was 93.64% and the recovery rate was 63.33%. Further biochemical studies showed that adding exogenous ABA increased the contents of endogenous osmotic regulatory substances (proline, soluble sugar, soluble protein) and reduced the activities of caspase-3-like and caspase-9-like enzyme that characterize programmed cell death (PCD). This suggests that the addition of ABA during preculture phase improved viability of shoot tips by affecting osmotic stress and PCD.
Irreversibility Analysis of Electromagnetic Hybrid Nanofluid Over a Stretchable Surface with Cattaneo-Christov Heat Flux Model: Finite Element Approach
Authors: Qureshi Muhammad Amer
Published: November 2022

To get a better heat transmission capacity of ordinary fluids, new hybrid nanofluids (HNFs) with a considerably greater exponent heat than nanofluids (NFs) are being used. HNFs, which have a greater heat exponent than NFs, are being applied to increase the HT capacities of regular fluids. Two-element nanoparticles mixed in a base fluid make up HNFs. This research investigates the flow and HT features of HNF across a slick surface. As a result, the geometric model is explained by employing symmetry. The technique includes nanoparticles shape factor, Magnetohydrodynamics (MHD), porous media, Cattaneo-Christov, and thermal radiative heat flux effects. The governing equations are numerically solved by consuming a method known as the Galerkin finite element method (FEM). In this study, H2O-water was utilized as an ironic, viscous improper fluid, and HNF was investigated. Copper (Cu) and Titanium Alloy (Ti6Al4V) nanoparticles are found in this fluid. The HT level of such a fluid (Ti6Al4V-Co/H2O) has steadily increased in comparison to ordinary Co-H2O NFs, which is a significant discovery from this work. The inclusion of nanoparticles aids in the stabilization of a nanofluid flowing and maintains the symmetry of the flow form. The thermal conductivity is highest in the boundary-lamina-shaped layer and lowest in sphere-shaped nanoparticles. A system's entropy increases by three characteristics: their ratio by fractional size, their radiated qualities, and their heat conductivity modifications.
Extended Chebyshev Wavelet of First Kind and its Applications in Approximation of a Function Belonging to Hölder’s Class and Solution of Fredholm Integral Equation of Second Kind
Authors: Lal Shyam , Yadav Harish Chandra
Published: November 2022

Note: Please see pdf for full abstract with equations.
In this paper, six approximations E(1)µk,0, E(1)µk,M, E(2)µk,0, E(2)µk,M,E(3)µk,0,E(3)µk,M of functions of classes H α[0, 1), H α,χ[0, 1), H ϕ[0, 1) by (µk, 0)th and (µk, M)th partial sums of their first kind extended Chebyshev wavelet expansion inthe interval [0, 1), for µ > 1, have been estimated. The solution of the Fredholm integral equation of the second kind by the first kind extendedChebyshev wavelets have been obtained. The solution obtained by extended Chebyshev wavelet of the first kind is approximately the same astheir exact solution. This is a significant achievement of this researchpaper in wavelet analysis.
Mathematics Subject Classification: 42C40, 45B05, 65T60, 65R20.
The role of the ecological scaffold in the origin and maintenance of whole-group trait altruism in microbial populations
Authors: Jones Christopher Thomas , Meynell Letitia , Neto Celso , Susko Edward , Bielawski Joseph Patrick
Published: November 2022

Background
Kin and multilevel selection provide explanations for the existence of altruism based on traits or processes that enhance the inclusive fitness of an altruist individual. Kin selection is often based on individual-level traits, such as the ability to recognize other altruists, whereas multilevel selection requires a metapopulation structure and dispersal process. These theories are unified by the general principle that altruism can be fixed by positive selection provided the benefit of altruism is preferentially conferred to other altruists. Here we take a different explanatory approach based on the recently proposed concept of an “ecological scaffold”. We demonstrate that ecological conditions consisting of a patchy nutrient supply that generates a metapopulation structure, episodic mixing of groups, and severe nutrient limitation, can support or “scaffold” the evolution of altruism in a population of microbes by amplifying drift. This contrasts with recent papers in which the ecological scaffold was based on selective processes, and therefore demonstrates the power of the scaffolding even in the absence of selection.
Results
Using computer simulations motivated by a simple theoretical model, we show that, although an altruistic mutant can be fixed within a single population of non-altruists by drift when nutrients are severely limited, the resulting altruistic population remains vulnerable to non-altruistic mutants. We then show how the imposition of the “ecological scaffold” onto a population of non-altruists alters the balance between selection and drift in a way that supports the fixation and subsequent persistence of altruism despite the possibility of invasion by non-altruists.
Conclusions
The fixation of an altruistic mutant by drift is possible when supported by ecological conditions that impose a metapopulation structure, episodic mixing of groups, and severe nutrient limitation. This is significant because it offers an alternative explanation for the evolution of altruism based on drift rather than selection. Given the ubiquity of low-nutrient “oligotrophic” environments in which microbes exist (e.g., the open ocean, deep subsurface soils, or under the polar ice caps) our results suggest that altruistic and cooperative behaviors may be highly prevalent among microbial populations.
The Influence of Day 3 Embryo Cell Number on the Clinical Pregnancy and Live Birth Rates of Day 5 Single Blastocyst Transfer from Frozen Embryo Transfer Cycles
Authors: Wang Jie , Diao Zhenyu , Fang Junshun , Zhu Lihua , Xu Zhipeng , Lin Fei , Zhang Ningyuan , Chen Linjun
Published: November 2022

Background: To evaluate the influence of day 3 embryo cell number on the clinical pregnancy and live birth rates of day 5 single blastocyst transfer in frozen embryo transfer (FET) cycles.
Methods: Our retrospective study included 3761 day 5 single blastocyst FET cycles between January 2015 and December 2019. These FET cycles were divided into three groups according to the day 3 embryo cell number: 939 cycles in the < 8-cell group, 1224 cycles in the 8-cell group and 1598 cycles in the > 8-cell group. The clinical pregnancy and live birth rates were compared among the three groups.
Results: The clinical pregnancy rate of day 5 single blastocyst transfer in FET cycles increased significantly as the day 3 embryo cell number increased (52.2%, 61.4% and 66.8%, P<0.001). Similarly, the live birth rate increased significantly as the day 3 embryo cell number increased (42.7%, 49.8% and 54.9%, P<0.001).
Conclusion: The clinical pregnancy and live birth rates will increase significantly as the day 3 embryo cell number increases when day 5 single blastocyst transfer in FET cycles is performed. A blastocyst derived from an embryo with a faster development speed on day 3 in FET cycles can shorten the time to achieving a live birth.
NudCL2 is essential for cytokinesis by stabilizing RCC2 with Hsp90 at the midbody
Authors: Xu Xiaoyang , Huang Yuliang , Yang Feng , Sun Xiaoxia , Lin Rijin , Feng Jiaxing , Yang Mingyang , Shao Jiaqi , Zhou Tianhua , Yang Yuehong
Published: November 2022

Cytokinesis is required for faithful division of cytoplasmic components and duplicated nuclei into two daughter cells. However, its underlying mechanism remains elusive. Here, we show that an Hsp90 co-chaperone NudC-like protein 2 (NudCL2) regulates cytokinesis by stabilizing regulator of chromosome condensation 2 (RCC2) in mammalian cells. NudCL2 co-localizes with RCC2 at the midbody and is required for RCC2 stabilization. Either NudCL2 knockout (KO) or RCC2 depletion causes similar phenotypes, including cytokinesis failure, midbody disorganization, and multinucleation. Ectopic expression of RCC2 effectively reverses the cytokinesis defect induced by NudCL2 KO. Furthermore, Hsp90 is also found to co-localize with NudCL2 at the midbody and is involved in NudCL2-mediated RCC2 stability and cytokinesis. Interestingly, our results reveal that the mRNA and newly synthesized peptides of RCC2 accumulate at the midbody. Loss of NudCL2 decreases the nascent RCC2, but not RCC2 mRNA, at the midbody. Taken together, our data provide a previously undescribed mechanism showing that NudCL2/Hsp90/RCC2 pathway is essential for cytokinesis at the midbody.
Resveratrol attenuates chronic unpredictable mild stress-induced alterations in the SIRT1/PGC1α/SIRT3 pathway and associated mitochondrial dysfunction in mice
Authors: Tabassum Sidra , Misrani Afzal , Huang Hui-xian , Zhang Zai-yong , Li Qiao-wei , Long Cheng
Published: November 2022

Environmental challenges, specifically chronic stress, have long been associated with neuropsychiatric disorders, including anxiety and depression. Sirtuin-1 (SIRT1) is a NAD+-dependent deacetylase that is widely distributed in the cortex and is involved in stress responses and neuropsychiatric disorders. Nevertheless, how chronic stress modulates the SIRT1 pathway and associated signaling remains unclear. In this study, we first explored the impact of chronic unpredictable mild stress (CUMS) on the SIRT1/PGC1α/SIRT3 pathway, on GABAergic mechanisms, and on mitophagy, autophagy and apoptosis in mice. We also asked whether activation of SIRT1 by resveratrol (RSV) can attenuate CUMS-induced molecular and behavioral alterations. Two-month-old C57/BL6J mice were subjected to three weeks of CUMS and one week of RSV treatment (30 mg/kg; i.p.) during the third week of CUMS. CUMS caused downregulation of the SIRT1/PGC1α/SIRT3 pathway leading to impaired mitochondrial morphology and function. CUMS also resulted in a reduction in numbers of parvalbumin-positive interneurons and increased oxidative stress leading to reduced expression of autophagy- and mitophagy-related proteins. Strikingly, activation of SIRT1 by RSV ameliorated expression of SIRT1/PGC1α/SIRT3, and also improved mitochondrial function, GABAergic mechanisms, mitophagy, autophagy and apoptosis. RSV also rescued CUMS-induced anxiety-like and depressive-like behavior in mice. Our results raise the compelling possibility that RSV treatment might be a viable therapeutic method of blocking stress-induced behavioral alterations.
How Do Logistics Disruptions Affect Rural Households? Evidence from COVID-19 in China
Authors: Nan Li , Chen Muzi , Huang Difang
Published: November 2022

Using a comprehensive survey of households during the early stage of the COVID-19 pandemic in China, we find that logistics disruptions due to the lockdown have resulted in severe economic losses for rural households. Further analysis shows that storage of agricultural inputs and outputs, insurance, and macroeconomic factors are associated with such losses during this period. We further examine the mechanisms by which logistics disruptions affect rural households, including both sales and production channels in agricultural supply chains. The former includes changes in product prices and reduced sales, while the latter includes changes in input prices and shortages of raw materials, capital, and labor. Of these channels, logistics has the most severe impact on sales. Opening up the logistics of sales channels is the primary policy choice. More storage warehouses and insurance are also important preemptive measures. Building stable and sustainable agricultural supply chains ensure rural households' production during the pandemic.
Clinical prospective study of Gallium 68 (68Ga)–labeled fibroblast-activation protein inhibitor PET/CT in the diagnosis of biliary tract carcinoma
Authors: Li Jinghua , Xu Kui , Guo Deliang , Liao Bo , Zhu Qian , Wang Haitao , Jiang Yaqun , Wu Dongde , Xia Xigang , Jiang Ping , Tang Shengli , Yang Zhiyong , He Yueming , Zhang Zhonglin , He Yong , Yuan Yufeng
Published: November 2022

Purpose
To investigate the 68Ga–labeled fibroblast-activation protein inhibitor (68Ga-FAPI) PET/CT diagnosis performance in biliary tract carcinoma (BTC), and analyze the association between 68Ga-FAPI PET/CT and clinical indexes.
Methods
A prospective study (NCT 05264688) was performed between January 2022 through July 2022. Fifty participants were scanned using 68Ga-FAPI and 18F-FDG PET/CT and acquired pathological tissue.
We employed the Wilcoxon signed-rank test to compare the uptake of 68Ga-FAPI and 18F-FDG, and the McNemar test was used to compare the diagnostic efficacy between the two tracers. Spearman or Pearson correlation was used to assess the association between 68Ga-FAPI PET/CT and clinical indexes.
Results
In total, 47 participants (mean age 59.09±10.98 [range 33–80 years]) were evaluated. The 68Ga-FAPI detection rate was greater than 18F-FDG in primary tumors (97.62% vs. 85.71%), nodal metastases (90.05% vs. 87.06%), distant metastases (100% vs. 83.67%). The uptake of 68Ga-FAPI was higher than 18F-FDG in primary lesions (intrahepatic cholangiocarcinoma: 18.95±7.47 vs. 11.86±0.70, p=0.001; extrahepatic cholangiocarcinoma:14.57±6.16 vs. 8.80±4.74, p=0.004), abdomen and pelvic cavity nodal metastases (6.91±6.56 vs. 3.94±2.83, p<0.001), distant metastases (pleural, peritoneum, omentum, and mesentery: 6.37±4.21 vs. 4.50±1.96, p=0.01; Bone: 12.15±6.43 vs. 7.51±4.54, p=0.008). There was a significant correlation between 68Ga-FAPI uptake and FAP expression (Spearman r=0.432, p=0.009), carcinoembryonic antigen (CEA) (Pearson r=0.364, p=0.012), and platelet (PLT) (Pearson r=0.35, p=0.016). Meanwhile, a significant relationship between 68Ga-FAPI metabolic tumor volume (MTV) and carbohydrate antigen199 (CA199) (Pearson r=0.436, p=0.002) was confirmed.
Conclusion
68Ga-FAPI preceded 18F-FDG in diagnosing BTC to a certain extent. The correlation between 68Ga-FAPI PET/CT indexes and FAP expression, CEA, PLT, and CA199 were confirmed.
Limestone mining area mapping and assessment at the Cement Industrial area using Spectral Index and Machine Learning Algorithms
Authors: C Venkata Sudhakar
Published: November 2022

Limestone mining contributes significantly to the Gross Domestic Product (GDP) of any country but it comes with some adverse impacts on the environment. The objective of this study is to determine the spatial distribution area of limestone mines using remote sensing, spectral index, and machine learning algorithms and compare their area estimation with industrial data for the financial year 2019. The study area includes a limestone mining area, of approximately 2226.16 ha with an excavation mining area of 487.10 ha at the Yerraguntla cement industrial region, YSR Kadapa district, Andhra Pradesh, India. In this study, we used the normalized vegetation index (NDVI), iterative self organizing data analysis technique (ISODATA), K-Nearest Neighbors (KNN), and random forest (RF) algorithms to analyze multispectral Sentinel-2A satellite data in QGIS 3.18 software tool. The RF classifier estimated a limestone mine area of 379.57 ha with best user accuracy (UA) 97.25% and producer accuracy (PA) 99.18% with a kappa coefficient value of 0.957. The mine area estimated 417.47 ha with UA of 98.99% and PA of 99.10% and kappa value 0.947 of the KNN method, The NDVI method estimated 469.92 ha with UA of 93.63% and PA of 92.04% and kappa value 0.685. This study confirmed that RF classifier well performed in classification with overall accuracy (OA) of 95.79% than KNN (OA of 94.78%), and NDVI (OA of 79.84%) classifiers, and ISODATA is poor in classification with OA of 64.16%. This study supports environmentally sustainable decisions, eco-friendly mine planning and monitoring for limestone mine owners and environmental engineers.
Successful surgical treatment for tension pyopneumothorax caused by Parvimonas micra: A case report
Authors: Iijima Yoshihito , Iwai Shun , Motono Nozomu , Uramoto Hidetaka
Published: November 2022

Background

Tension pyopneumothorax is a rare and life-threatening complication of pneumonia, lung abscess and empyema, and immediate thoracic drainage or surgery is required in most cases.

Case presentation

A 70-year-old man presented to another hospital 2 weeks after exacerbation of dyspnea and inability to eat. Supine chest x-ray imaging revealed leftward deviation of the mediastinum, pleural effusion and collapse of the right lung. The patient was then referred to our hospital for surgical treatment. He underwent chest drainage immediately after the transfer. The patient’s blood pressure was elevated after drainage. Chest x-ray imaging showed improvement in the mediastinal deviation, but expansion failure of the lung occurred. Debridement and parietal and visceral decortications were performed. The thoracic cavity was irrigated using a pulse lavage irrigation system with 12,000 ml of saline. The patient underwent fibrinolytic therapy with intrathoracic urokinase postoperatively. Parvimonas mica was detected in the preoperative pleural fluid culture. The patient was discharged on postoperative day 22 and followed up as an outpatient afterwards. Two years have passed since the surgery, and there has been no recurrence of empyema.

Conclusions

We successfully treated a rare case of tension pyopneumothorax caused by P. micra. The patient developed tension pyopneumothorax due to gas production from an anaerobic bacterial infection. Decortication of the parietal and visceral pleura and irrigation using a pulse lavage irrigation system were effective in treating the condition.
Immunogenic cell death-related classifications guide prognosis and immunotherapy in osteosarcoma
Authors: Zong Yuan , Cao Yu , Zhang Ding , Guan Xiaoqing , Zhang Fengyi , Shen Zhubin , Yin Fei
Published: November 2022

Purpose Immunogenic cell death (ICD) is a form of cell death that stimulates the immune system to produce an immune response by releasing tumor-associated antigens and tumor-specific antigens, and is considered to play an important role in tumor immunotherapy.
Methods In the present study, we identified two ICD-related subtypes in osteosarcoma (OS) by consensus clustering. We also established and validated an ICD-related prognostic model.
Result ICD-low subtype is associated with favorable clinical outcomes, abundant immune cell infiltration, and high activity of immune response signaling. The modle could not only be used to predict the overall survival of OS patients, but was also found to be closely related to the tumor immune microenvironment of OS patients.
Conclusion We have established a new classification system for OS based on ICD-related genes, which can be used to predict the prognosis of OS patients and the selection of immunotherapy drugs.
DNA methylation-based biomarkers and prediction models for the survival of patients with colorectal cancer: systematic review and external validation study
Authors: Yuan Tanwei , Edelmann Dominic , Kather Jakob N. , Fan Ziwen , Tagscherer Katrin E. , Roth Wilfried , Bewerunge-Hudler Melanie , Brobeil Alexander , Kloor Matthias , Bläker Hendrik , Burwinkel Barbara , Brenner Hermann , Hoffmeister Michael
Published: November 2022

Background
DNA methylation biomarkers (e.g., methylation level at CpG sites) have the potential to improve prognostic accuracy for patients with colorectal cancer (CRC). We identified existing DNA methylation-based prognostic biomarkers and prediction models for CRC prognosis and validated them in a large external cohort.
Methods Epigenome-wide studies reporting CpGs associated with survival among CRC patients were retrieved by systematic literature search until October 2022. Validation data were drawn from the 2310 CRC patients of the DACHS study recruited from 22 hospitals in the Rhine-Neckar region in the southwest of Germany. Cox regression analyses with adjustment for clinical variables were performed to validate individual CpGs and prognostic models. Model discriminiation and calibration accuracy were assessed by area under the receiver operating characteristic curves (AUC) and calibration plots.
Results We identified 200 unique CpGs and 10 CpG-based prognostic models derived from 15 studies. In the external validation analysis, 1252 of 2310 patients died during follow-up (median 10.4 years). Thirty-nine CpGs (20%) and five prognostic models (50%) were independently associated with overall survival after adjustment for clinical variables. The discrimination ability for the five models was unsatisfactory, with AUCs ranging from 0.53 to 0.60. The calibration accuracy of the five models using recalibrated baseline survival was also poor. All five models can provide only small added prognostic value to traditional clinical variables. All prognostic models were rated as high risk of bias.
Conclusions Only a fraction of published CpGs associated with survival in CRC patients could be externally validated. So far derived published CpG-based prognostic models for CRC do not seem to be useful for clinical practice.
Closed-form solutions to investigate the nonlinear response of foundations supporting operating machines under blast loads
Authors: Abd-Elhamed Ayman
Published: November 2022

Machine foundations are subjected to significant dynamic impacts. These impacts could spread to the surrounding regions, affecting workers, sensitive equipment in the same institution, or nearby areas. This study analyzes the response of machine-supporting foundations to harmonic and explosive loads under operational conditions and provides closed-form solutions for predicting responses in terms of displacement, velocity, and acceleration time-histories to two common types of blast loads: a more accurate typical profile and simplified triangular profile. The soil-machine foundation system is regarded as a single-degree-of-freedom (SDOF) system that exhibits elastic–perfectly flexible resistance behavior. For the analysis of the SDOF system, two cases are considered: one assumes that the supporting soil keeps elastic during the explosion, and the peak displacement is less than the elastic one, while the other assumes that the blast occurs in an elastic state, and the peak displacement occurs in a plastic state. By using the closed-form analytical solutions, a detailed parametric analysis is carried out to evaluate the impacts of significant soil-foundation system characteristics such as mass, stiffness, and damping ratio on the response-time history of machine foundations. The findings are compared to those reported in the literature, and relevant conclusions are derived. Obtained results demonstrated that, despite its simplicity and usage of only positive phase to simulate blast loads, the simplified model's response behavior differs significantly from the typical one. Furthermore, the derived solutions are utilized to design the foundations supporting vibrating machines for both harmonic and blast loads in a variety of conceivable scenarios depending on the blast magnitude.
Penalized empirical likelihood estimation and EM algorithms for closed-population capture--recapture models
Authors: Liu Yang , Li Pengfei , Liu Yukun
Published: November 2022

Capture--recapture experiments are widely used to estimatethe abundance of a finite population.Based on capture--recapture data, the empirical likelihood (EL) methodhas been shown to outperform the conventionalconditional likelihood (CL) method.However, the current literature on EL abundance estimationignores behavioral effects,and the EL estimates may not be stable,especially when the capture probability is low.We make three contributions in this paper.First, we extend the EL method to capture--recapture models that account for behavioral effects.Second, to overcome the instability of the EL method,we propose a penalized EL (PEL) estimation methodthat penalizes large abundance values.We then investigate the asymptotics of the maximum PEL estimator and the PEL ratio statistic.Third, we develop %novelstandard expectation--maximization (EM) algorithmsfor PEL to improve its practical performance.The EM algorithm is also applicable to EL and CL with slight modifications.Our simulation and a real-world data analysis demonstrate that the PEL method successfully overcomes the instability of the EL methodand the proposed EM algorithm produces more reliableresults than existing optimization algorithms.
Vaping-Induced Acute Epiglottitis: A Case Report
Authors: Khorrami Amir , Gheriani Heitham
Published: November 2022

Background: E-cigarette use or vaping, is an alternative nicotine delivery system that is becoming increasingly prevalent in the adolescent and young adult population. There is currently a lack of comprehensive research on the adverse effects of vaping on the upper airway.
Acute epiglottitis is a potentially life-threatening condition that can lead to airway obstruction. It is most commonly caused by bacterial infections such as streptococci, staphylococcus, and Moraxella. Adult patients with acute epiglottitis mainly present with odynophagia, dysphagia, and respiratory difficulties. The diagnosis of epiglottitis is made by direct laryngoscopy, and the mainstay of treatment is antibiotics.
Bozella et al. reported a case of subacute non-infectious epiglottitis associated with e-cigarette use in a pediatric patient. Here we present a case of acute epiglottitis in a healthy young adult after vaping, with a negative infectious investigation. To our knowledge, there has been no such reported case of epiglottitis associated with e-cigarette use in an adult patient.
Case description: A previously healthy 29-year-old male with daily e-cigarette use presented to the emergency department with a severe sore throat, dysphagia, mild hoarseness, and shortness of breath especially when lying supine. A lateral neck soft tissue radiograph revealed a thickened epiglottis with a thumb sign. Direct bedside laryngoscopy showed a swollen epiglottis, partially obstructing the supraglottic region confirming the diagnosis of acute epiglottitis. A throat swab was negative for streptococcus infection. The patient received intravenous dexamethasone and antibiotics for two days and improved significantly. Repeat laryngoscopy showed the resolution of epiglottis swelling and patients’ symptoms had completely resolved two weeks after start of treatment.
Conclusions: Even though bacterial infections usually cause acute epiglottitis, this case presents the second report of this condition associated with vaping with negative microbiological investigations. Therefore, we recommend physicians consider non-infectious causes such as vaping in their differential diagnosis in patients presenting with acute and subacute epiglottitis. More research is warranted on the utility of antibiotics for the treatment of vaping-induced epiglottitis.
The study of Overexpression of Peroxiredoxin-2 Reduces MPP+-Induced Toxicity in SH-SY5Y Neuroblastoma Cells
Authors: Liu Menghao , Zuo Shuqian , Guo Xing , Peng Junyu , Xing Yaoping , Guo Yanjie , Li Chaokun , Xing Hongxia
Published: November 2022

Parkinson’s disease (PD) is a neurodegenerative disorder characterized by dopaminergic neuron loss. Excessive reactive oxygen species (ROS) accumulation has been implicated in the pathogenesis of Parkinson’s disease. Endogenous Peroxiredoxin-2 (Prdx-2) has potent anti-oxidative and anti-apoptotic effects. For further study of the activation of Prdx-2 and its role in vitro, SH-SY5Y cells were treated with MPP+ or transfected with Prdx-2. The results showed that MPP+ raises intracellular ROS, depolarizes mitochondrial membrane potential, decreases cell activity, and reduces expression of tyrosine hydroxylase (TH), Prdx-2, Silent Information Regulator of Transcription 1 (SIRT1), and increases the proapoptotic/anti-apoptotic expression ratio (Bax/Bcl2). When cells were transfected with Prdx-2, TH and SIRT1 were increased, the Bax/Bcl-2 ratio was decreased, ROS content was decreased, and cell activity was enhanced. However, this study not directly test whether Prdx-2 affects the downstream signaling factors of SIRT1.This will be the focus of the next stages of research.
Determinants of effectiveness of computer-assisted audit techniques in the public sector
Authors: Purnamasari Pupung , Hartanto Rudy
Published: November 2022

The increasing complexity of transaction processes in every organization, both private and public, has led auditors to develop computer-assisted audit techniques (CAATs). However, potential risks, difficulties, and challenges can hinder the effective implementation of CAATs. The purpose of this study was to examine the factors that influence the effectiveness of the implementation of CAATs in the auditor public sector. The study collected the data by distributing questionnaires to respondents. The sample comprised 225 government auditors in Indonesia, namely the Audit Board of the Republic of Indonesia (BPK). The data were analyzed using the least squares structural equation modeling and importance performance matrix analysis (IPMA). The results show that auditor competence and system quality support the effectiveness of using CAATs. In addition, policies and audit evidence do not affect the effectiveness of CAATs’ use. Other test results using IPMA show that the most critical variable influencing performance is competence in support of increasing the effectiveness of CAATs. These findings indicate that the effectiveness of CAATs use in BPK as a government audit agency requires the support of auditor competence and system quality.
Identification of Bird Species in Argowiloso Peak Mount Muria
Authors: Ridlo Muhammad , Setyawati Siti Mukhlishoh , Hidayat Saifullah
Published: November 2022

AbstractIndonesia is a country that has abundant flora and fauna. Mount Muria, Kudus Regency, Central Java has a high potential for bird biodiversity. The area which is a natural protected forest area, is very supportive for the existing bird habitat. However, this potential is still rarely known by the general public due to the lack of publications. The aims to find out and analyze the types of birds and to find out and analyze the condition of the bird habitat found in the Mount Muria area. The research was conducted using the transect method with 3 observation stations. The observed birds were then photographed and identified based on the field guide of MacKinnon. The results showed that 22 species 18 families were identified, including: Campephagidae, Vangidae, Sittidae, Pycnonotidae, Rhipiduridae, Nectariniidae, Eurylaimidae, Pellorneidae, Hirundinidae, Cisticolidae, Dicaeidae, Pittidae, Alcedinidae, Meropidae, Megalaimidae, Apodidae, Accipitridae and Cuculidae. Habitat conditions are strongly influenced by biotic and abiotic components to support the survival and diversity of birds on Mount Muria
Application of Liquid Organic Fertilizer on Sandalwood (Santalum album L.) invitro from East Nusa Tenggara
Authors: Solle Hartini
Published: November 2022

Sandalwood (Santalum album L.) which grows in East Nusa Tenggara is an endemic plant known as hau meni. Sandalwood is used as a base for carving and perfume containing essential oils that have a distinctive aroma. The superiority that is owned causes the selling price is very expensive. This causes exploitation which results in a diminishing number of Sandalwood trees. Efforts to replant have been carried out through seedlings and nurseries but the success rate is still low. Efforts through invitro are expected to help conserve this plant. To determine the effect of giving Liquid Organic Fertilizer (LOF) on the growth of Sandalwood and the best concentration in promote germination. The study was conducted by adding different types of LOF with concentration variation. The addition of Nasa with a concentration of 2 mL which is the optimal concentration in promote the germination with the response at 14 Days After Planting (DAP) on Murashige and Skoog (MS) medium while on the addition of lontar the concentration of 2 mL shows the response of the appearance of plumula. The addition of base type LOF on MS medium affected 82% germination percentage while lontar type LOF stimulated vegetative growth of Sandalwood plants.
Exploratory Data Analysis of Exact Science and Social Science Learning Content on Digital Platform
Authors: Mambang Mambang -
Published: November 2022

Data is one of the essential aspects in providing new information and new knowledge so that the data exploration process can provide policies on a decision for many sectors. Exploratory Data Analysis in this paper begins with collecting datasets contained on the Youtube digital platform. The dataset used was 30 samples found on the top page of youtube in each keyword. After conducting the Exploratory Data Analysis process, we found new learning content on the digital youtube platform. From the Exploratory Data Analysis that has been carried out, we also find different variations of the analysis's variables. The duration variable shows the result that the total duration of the overall duration in mathematics learning content that includes the Exact Science field is less than the psychology learning content included in the Social Science field. Meanwhile, the overall number of views on mathematics learning content is more than the number of views on psychology learning content. From the collecting dataset that we have made, showing a considerable number of views is undoubtedly the key to equitable distribution of information and knowledge for all users. More innovation and creating learning content are expected to encourage increased human development.
Sistem Pendukung Keputusan Pemilihan Duta Pelajar IPNU IPPNU Menggunakan Metode Simple Additive Weighting (SAW)
Authors: Mawarda Ella , Mahendra Danang , Akbar Agus Subhan
Published: November 2022

IPNU IPPNU merupakan organisasi pelajar di bawah naungan Nahdlatul Ulama (NU). Untuk menigkatkan pemahaman keaswajaan, Ke-NU-an, keorganisasian, dan kebangsaan, IPNU IPPNU membuat sebuah program yang bernama pemilihan duta IPNU IPPNU tingkat kabupaten. Proses pemilihan duta pelajar ini masih dilakukan secara manual, sehingga membuat proses pemilihan kurang efektif dan efisien, serta unsur subjektivitas masih sangat tinggi. Dalam makalah ini, penulis mengusulkan sebuah sistem pendukung keputusan untuk pemilihan duta pelajar. Sistem ini menggunakan metode Simple Additive Weighting (SAW) yang melakukan perhitungan dengan menentukan nilai bobot terlebih dahulu dari setiap kriteria, kemudian melakukan proses perhitungan untuk mendapatkan alternatif yang paling sesuai dengan kriteria. Aplikasi diujicobakan kepada panitia pemilihan duta pelajar untuk mengevaluasi kinerjanya.  Berdasarkan black box testing dapat disimpulkan bahwa sistem yang dibangun dapat berfungsi dengan baik.
Fenomenologia e formalismo em Francis Ponge
Authors: Perius Cristiano
Published: November 2022

Este ensaio considera a obra poética de Francis Ponge a partir do debate entre dois movimentos teóricos: a fenomenologia e o formalismo. A partir de certa chave de interpretação proveniente da linguística estrutural, a fenomenologia não constitui um referencial teórico válido para a obra de Francis Ponge. Considerando o teor das críticas à fenomenologia provenientes do estruturalismo, este ensaio explora algumas iniciativas de respostas motivadas pela fenomenologia de Merleau-Ponty. A partir do nó górdio ou elo intrínseco entre as palavras e as coisas, nota-se que ambos os movimentos teóricos participam da composição poética do autor de O Partido das Coisas. Ao rebater as críticas do formalismo, a fenomenologia ganha um papel constitutivo na composição poética. Trata-se de explorar uma alternativa válida e conciliadora entre a fenomenologia e o formalismo.
A questão da guerra: Entre Carl Schmitt e Hannah Arendt
Authors: De Oliveira Vaz Mário Sérgio , Dos Santos Maria Fernanda
Published: November 2022

O artigo apresenta uma reflexão sobre a guerra a partir de Carl Schmitt e Hannah Arendt. Para tanto, realiza-se um recorte na obra de cada autor. De Carl Schmitt, discute-se o livro O conceito do político (2009) que contém ainda A teoria do Partisan. De Hannah Arendt, restringe-se a Sobre a violência (2001), A promessa da política (2020), e alguns ensaios contidos em Entre o passado e o futuro (2009). Neste sentido, Carl Schmitt permite discutir o papel da inimizade para a decisão acerca da guerra e como essa situação-limite, ao mesmo tempo, constitui e afeta a dimensão do político. Já Hannah Arendt permite delinear certos traços constitutivos das guerras modernas que escapam à preocupação central Schmittiana, sobretudo o perigo intrínseco da inimizade produzir não a intensificação do político, mas a eliminação da vida humana sobre à Terra. Trata-se, enfim, de pensar o efeito do avanço tecnológico no campo dos assuntos humanos e como essa tópica transforma o estatuto da guerra.
O cosmopolitismo em questão: Habermas versus Schmitt
Authors: Cordeiro Roan Costa
Published: November 2022

Este artigo propõe investigar o confronto de Jürgen Habermas com Immanuel Kant e Carl Schmitt sobre os fundamentos de um projeto jurídico-político cosmopolita. Para isso, percorrendo o trajeto de Habermas entre A inclusão do outro (1996) e Sobre a constituição da Europa (2011), explora-se como ocorre esse enfrentamento e qual seu papel estratégico na conformação de um modelo jurídico-político pós-nacional. Diante disso, nota-se que Habermas, ao reivindicar o legado kantiano, tem de enfrentar os contrapontos teóricos levantados pelo pensamento de Carl Schmitt quanto à autocompreensão política da modernidade. Assim, pode-se situar um eixo de fundamentação do projeto político cosmopolita e também o papel desempenhado por Schmitt no quadro mais amplo dos debates políticos e filosóficos do presente.