bluuebunny/crossref_metadata_2025 huggingface dataset:
Micronutrient status of pregnant women with fetal congenital malformations
Authors: Milyutina Yulia P. , Shengelia Margarita O. , Bespalova Olesya N. , Pachuliya Olga V. , Blazhenko Aleksandra A. , Denisov Kirill А. , Sazonova Anastasia P. , Korenevsky Andrey V.
Published: November 2023

BACKGROUND:Congenital malformations of the central nervous system have extremely severe consequences, which makes it important to study their development and diagnosis during embryogenesis. Therefore, particularly relevant are studies in the field of prevention of fetal сongenital malformations.
AIM:The aim of this study was to assess the micronutrient status (vitamin D, serum and erythrocyte folic acid, vitamin B12) and homocysteine levels in women with induced abortion in the second trimester of pregnancy based on fetal indications (fetal сongenital malformations).
MATERIALS AND METHODS:This prospective cohort study enrolled 53 women with induced abortion for medical reasons from the fetus in the second trimester of gestation. All pregnant women were divided into two groups. Group 1 included 28 individuals without an established chromosomal abnormality in the fetus: with fetal сongenital malformations and no neural tube defects (n= 16) or with fetal сongenital malformations and neural tube defects (n= 12). Group 2 consisted of 25 pregnant women with established chromosomal abnormalities in the fetus.
RESULTS:In pregnant women with fetal сongenital malformations and neural tube defects, blood serum vitamin B12level correlated with erythrocyte folic acid level and was lower compared with women with fetal сongenital malformations and no neural tube defects (p 0.05). No significant differences were found for other parameters. In pregnant women with fetal сongenital malformations, homocysteine level did not differ from that in women with normal fetal development at this stage of pregnancy. Meanwhile, folic acid and vitamin B12levels in women with fetal сongenital malformations were lower compared with pregnant women without this pathology (p 0.001).
CONCLUSIONS:The features of micronutrient status found in patients with fetal сongenital malformations, in particular with neural tube defects, and the relationships between its individual parameters indicate complex etiologies of these pathologies. The data obtained indicate the expediency of assessing one-carbon metabolic parameters in the mother not only during pregnancy, but also at the stage of preconception preparation, as well as the need for additional research related to adequate control of vitamin intake and assessment of methionine cycle gene polymorphism.
CAUSING INFERTILITY TREATMENT ON INVERSION CHROMOSOME 9
Authors: Paskar Svetlana S. , Nikitin Sergei V. , Bogomolova Marina V. , Fomenkova Irina S. , Shutova Elena E.
Published: November 2023

The article presents a clinical case of infertility treatment in a womanwith inversion of chromosome 9. The clinical significance of this chromosomal rearrangement and the need for genetic counseling at the stage of pregnancy planning are analyzed. A case with successful infertility treatment using assisted reproductive technologies and PGT-A is described.
FROM THE HOSPITAL TO THE PERINATAL CENTER
Authors: Andreeva Anna V. , Baranov Alexey N. , Samburov Gleb O. , Tuchina Tamara A.
Published: November 2023

2023 marks the 160th anniversary of the creation of the Society of Arkhangelsk Doctors (OAB), through whose efforts the first free hospital for northerners was opened in Arkhangelsk in the pre-revolutionary period. Exactly 100 years ago, in the nationalized building of this hospital, the first obstetric institution was created - the maternity hospital named after Concordia Nikolaevna Samoilova, which at the beginning of the XXI century became part of the Perinatal Center, created by merging the previously existing obstetric institutions of Arkhangelsk.
Evaluation of aromatase expression in endometrioid heterotopias and endometria in patients with external genital endometriosis
Authors: Malysheva Olga V. , Molotkov Arsenii S. , Shved Natalia Yu. , Mikhailova Marina A. , Yarmolinskaya Maria I.
Published: November 2023

BACKGROUND:External genital endometriosis is a multifactorial estrogen-dependent disease. Local estrogen production due to aromatase activity can play an important role in its pathogenesis, so aromatase inhibitors are considered promising drugs for the treatment of the disease. However, the data on their effectiveness are contradictory.
AIM:The aim of this study was to evaluate the expression level of the aromatase-encodingCYP19A1gene in the eutopic endometrium and endometrioid heterotopies of patients with endometriosis and in the eutopic endometrium of women from the comparison group.
MATERIALS AND METHODS:This study included 79 women. The main group consisted of 55 patients with endometriosis, and 24 patients without endometriosis formed a comparison group. All of the patients underwent an endometrial biopsy during surgery, with excision of endometriotic lesions performed in patients with endometriosis.CYP19A1gene expression was studied using reverse transcription real-time polymerase chain reaction.
RESULTS:The data obtained confirm a high level of aromatase expression in endometriosis foci. On average, aromatase expression is increased in the eutopic endometrium of patients with endometriosis when compared to the endometrium of women in the comparison group. However, in a significant number of patients with endometriosis, aromatase is expressed in the endometrium at a low level. We did not find an association of increased aromatase expression with any clinical and anamnestic features of the studied group of women, in particular, with infertility, pain syndrome, prevalence of endometriosis, or relapses of the disease.
CONCLUSIONS:Our findings highlight the heterogeneity of endometriosis and may account for the variable effectiveness of hormone-modulating therapy, in particular aromatase inhibitors.
Experiences with NeonFSC stress monitoring system for perioperative pain control in pediatric neurosurgery: a prospective observational study
Authors: Tere Valentina A. , Kulikov Aleksandr S. , Lubnin Andrei Y. , Satanin Leonid A.
Published: November 2023

BACKGROUND: Prevention and treatment of pain is the primary goal of any anesthesiologist. This would entail meticulous assessment of pain, especially in children. However, there have been no comprehensive and objective methods developed to assess pain. Only a number of algometers based on the basic biology of the nociceptive system are currently used in clinical practice.
OBJECTIVE: Our aim was to document and analyze the experience of using NeonFSC stress monitoring system (LLC «VKO Fiziomed», Russia) in clinical practice for perioperative pain control in pediatric neurosurgery.
MATERIALS AND METHODS: We conducted a pilot prospective observational study that included 44 patients (18 girls and 26 boys) who were treated at the Burdenko National Medical Research Center for Neurosurgery at the age of 3 months to 18 years (Class I–II ASA). Patients received intraoperative fentanyl and postoperative administration of paracetamol round-the-clock and tramadol as needed. All patients underwent perioperative pain assessment using clinical data and pain assessment scales and the NeonFSC device. All patients were observed in the wake-up ward 3- minutes postextubation until transfer to the pediatric ward. Out of 44 patients, fourteen patients registered stress response in the NeonFSC monitoring system. Pain measured clinically using the Visual Analog Scale and FLACC were compared with NeonFSC data.
RESULTS: No signs of prolonged insufficient analgesia were observed in any patient intraoperatively. The CSP index, an integral indicator of the patient’s status, demonstrated adequate level of anesthesia and analgesia during the operations (from 0 to 18 points). We demonstrated that the CSP index and clinical assessment of pain were concordant in 10 (71%) cases. Four of these children reported moderate pain and six showed mild pain.
CONCLUSION: NeonFSC stress monitoring system is noninvasive and does not cause patient discomfort during recording. However, system indicators should be interpreted in the context of the overall clinical condition of the patient.
Regional interfascial blocks in pediatric practice: a literature review
Authors: Satvaldieva Elmira A. , Shakarova Mehri U. , Mitryushkina Valeria P. , Ashurova Gulchekhra Z.
Published: November 2023

Regional anesthesia in frequently used during the perioperative period in both adult and pediatric patients to achieve better pain control and faster recovery after surgery. Significant progress in regional anesthesia has been achieved recently due to the availability of ultrasound guidance. In this systematic review and meta-analyses, randomized trials on the use of regional blocks in anesthesiology were evaluated, including new blockade techniques that expand the possibilities of regional anesthesia. Interfascial blocks are considered a subgroup of peripheral nerve blocks, a set of techniques that have been already employed in perioperative pain management. Their advantages include less invasiveness, significant reduction in the need for opioid analgesics, low complication rates, and flexibility of approaches to accommodate specific surgical needs. Despite considerable interest in interfascial blocks in pediatric anesthesiologists, data on its safety are lacking, with a few randomized controlled trials providing low-quality evidence. Future prospective studies are warranted to evaluate interfascial blocks in the pediatric population.
Morroniside ameliorates lipopolysaccharide-induced inflammatory damage in iris pigment epithelial cells through inhibition of TLR4/JAK2/STAT3 pathway
Authors:   The First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu Province, China; Department of Ophthalmology, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China, Li Wen-Jie , Lu Hong ,   The First Clinical Medical College, Lanzhou University, Lanzhou 730000, Gansu Province, China; Department of Ophthalmology, Beijing Chao Yang Hospital, Capital Medical University, Beijing 100083, China
Published: November 2023

AIM: To investigate the effect of morroniside (Mor) on lipopolysaccharide (LPS)-treated iris pigment epithelial cells (IPE).
METHODS: IPE cells were induced by LPS and treated with Mor. Cell proliferation was detected by cell counting kit (CCK) -8, apoptosis was detected by flow cytometry, the levels of tumor necrosis factor-α (TNF-α), interleukin (IL)-6, and IL-8 were measured by enzyme-linked immunosorbent assay (ELISA) kits, and the protein expression of TLR4, JAK2, p-JAK2, STAT3, and p-STAT3 was analyzed by Western blotting. In addition, overexpression of TLR4 and Mor treatment of LPS-stimulated IPE cells were also tested for the above indices.
RESULTS: Mor effectively promoted the proliferation and inhibited the apoptosis of LPS-treated IPE cells. In addition, Mor significantly reduced the levels of TNF-α, IL-6, and IL-8 and significantly inhibited the expression of TLR4, p-JAK2, and p-STAT3 in LPS-treated IPE cells. The effect of Mor on LPS-treated IPE cells was markedly attenuated after overexpression of TLR4.
CONCLUSION: These findings suggest that Mor may ameliorate LPS-induced inflammatory damage and apoptosis in IPE through inhibition of TLR4/JAK2/STAT3 pathway.
NUEVA ESPECIE COLOMBIANA DE BROWNINGIA (CACTACEAE, CACTOIDEAE, BROWNINGIEAE) POTENCIALMENTE PROMISORIA PARA EL PAÍS
Authors: Fernández-Alonso José Luis
Published: November 2023

Se describe e ilustra una nueva especie del género Browningia (Cactaceae), endémica de la cuenca alta del río Chicamocha (Boyacá, Colombia), que confirma la distribución disyunta de este género, hasta ahora considerado endémico de la región centroandina. Se comentan su hábitat y distribución y su condición de especie promisoria para el país.
SPHAGNUM (SPHAGNACEAE) EN EL DEPARTAMENTO DE BOYACÁ, COLOMBIA
Authors: Ruiz Suárez Erika Johana , Linares Edgar Leonardo , Morales-P María Eugenia
Published: November 2023

Se presenta el tratamiento taxonómico, acompañado de descripciones, datos de distribución y claves taxonómicas. Se registran 18 especies del género Sphagnum distribuidas en 5 secciones, ubicadas en 21 localidades de Boyacá, se señalan por primera vez para el departamento las especies: Sphagnum meridense, S. imperforatum, S. negrense, S. perichiatiale y S. flacidum.
CARACTERIZACIÓN MOLECULAR Y GENÓMICA DEL PROCESO DE INTEGRACIÓN DE PROVIRUS DEL VIRUS LINFOTRÓPICO HUMANO (HTLV) TIPO I
Authors: García Vallejo Felipe
Published: November 2023

Se estudió el proceso de integración del HTLV-I desde varios enfoques conceptuales y metodológicos, incluyendo estudios filogenéticos de la integrasa, sus características estructurales y la genómica estructural de la integración de provirus en células linfocitarias de individuos seropositivos. Estructuralmente se observó que los residuos HHCC en la región N-terminal y DDE en el centro catalítico de la enzima estaban conservados en las integrasas del HTLV-I/II, del VIH-1 y del ASV. El grado de expansión clonal de linfocitos infectados en individuos seropositivos con paraparesia espástica tropical, leucemia de células T del adulto y portadores asintomáticos fue variable. El número de amplicones de IPCR fue significativamente mayor en pacientes PET/HAM (8.6 ± 2.5) que en portadores asintomáticos (5.0 ± 1.7) o en pacientes ATL (2.8 ± 3.0) (P<0.004). Las secuencias del genoma humano de 50 nucleótidos que flanquean el 3'LTR presentaron grados de homología variable con cDNA provenientes de varias líneas celulares tumorales y de tejidos normales. Un alineamiento de tales secuencias permitió localizar cromosómicamente los diferentes provirus dentro del genoma humano. Los sitios de integración del HTLV-I en los individuos infectados estuvieron distribuidos de una manera no aleatoria, preferencialmente en secuencias ricas en GC. En los cromosomas 8, 9 y 16 se encontró una mayor cantidad de secuencias provirales. La hibridización sustractiva de fragmentos de DNA humano generados por AFLP permitió una de-dactilarización del fenómeno de integración dentro del genoma humano infectado, metodología que además es susceptible de ser utilizada en otros contextos moleculares.
ALTERACIÓN FÍSICA DE LOS FRAGMENTOS DE MATRIZ Y DE LOS VIDRIOS VOLCÁNICOS
Authors: M.T Flórez M. , Parra S L.N. , Malagón D.
Published: November 2023

Los diferentes componentes de las cenizas volcánicas no tienen igual susceptibilidad a meteorizarse, ello lo evidencian los resultados obtenidos en esta investigación, donde se tomaron tres de estos componentes: fragmentos de matriz, vidrios volcánicos coloreados y vidrios volcánicos incoloros los cuales, luego de haber estado sometidos a disolución durante dos años en ácido húmico, en agua acidulada y en ácido oxálico, permiten mostrar que, de ellos, son los fragmentos de matriz los que presentan mayor superficie específica, mayor superficie de reacción, mayor número de rasgos de alteración superficial y son los que producen mayores cantidades de iones de Al3+, Si4+ y Fe3+, por ello, son los más susceptibles de ser meteorizados.
Prácticas de educación permanente en atención primaria a la salud para el abordaje de personas usuarias con tuberculosis
Authors: Lourenço Letícia Vieira , Coelho Karla Santa Cruz , Merhy Emerson Elias
Published: November 2023

La interrupción del tratamiento contra la tuberculosis configura uno de los obstáculos para el control de la enfermedad. Las normas establecidas en las políticas de salud, a veces, se muestran poco flexibles, lo que tiende a invisibilizar las dificultades experimentadas por las personas en tratamiento. El objetivo de este artículo es analizar las prácticas de educación permanente en salud desarrolladas por los equipos de salud familiar de las unidades de salud de Maré, municipio de Río de Janeiro, Brasil, en casos de interrupción del tratamiento de la tuberculosis. Se realizó una investigación exploratoria de abordaje cualitativo con doce profesionales del equipo de salud en el periodo de agosto a noviembre de 2021. Los hallazgos de esta investigación consideran la educación permanente en salud como una estrategia de mejora de los procesos de cuidado, fomentada por la vivencia en acto de los trabajadores, que viabiliza la producción de saberes e intercambios que amplían el efectivo tratamiento de la tuberculosis, con creatividad y flexibilidad, en la dinámica de las relaciones con los usuarios, sea en los pasillos de las unidades de salud o en el territorio junto a la comunidad, dado que el cuidado ocurre en el trabajo vivo en acto.
Experiências de enfermeiros no cuidado à pessoa idosa na Rede de Atenção à Saúde em tempos de pandemia de COVID-19
Authors: Silva Carlos Jordão de Assis , Moraes Maria Fernanda Fernandes de , Gomes Flávio , Alcântara Meine Siomara , Moreira Patrícia Naiara de Oliveira , Gonçalves Rafaella Guilherme , Oliveira Luciane Paula Batista de
Published: November 2023

Objetivo: Relatar a experiência de enfermeiros no cuidado à pessoa idosa na rede de atenção à saúde do estado do Rio Grande do Norte no período de pandemia de COVID-19. Métodos: relato de experiência, desenvolvido em maio de 2020 por um grupo de seis enfermeiros atuantes em todos os níveis de complexidade, no setor público e privado. Resultados: as experiências vivenciadas foram descritas de acordo com o nível de atenção dos serviços de saúde, e suas apresentações se deram em eixos temáticos segundo o local de vivência de cada autor. Salienta-se que as experiências abarcam os cenários da Atenção Primária à Saúde, a Atenção hospitalar na atenção secundária e terciária, além do contexto do serviço particular e público-ensino. Discussões: a atuação do enfermeiro passou por adaptações devido à pandemia, incluindo novos fluxos de atendimento e rotinas que favoreçam a prevenção da transmissão desta doença. Na atenção primária, os profissionais têm oferecido atividades de estimulação cognitiva e física para os idosos domiciliados, com acompanhamento por telefone para evitar busca dispensável dos serviços de saúde. Na atenção hospitalar, a experiência de cuidar de pessoas idosas com COVID-19 revelou que, além de cuidados específicos com a doença, esses pacientes têm requerido maior atenção aos aspectos psicossociais, pois idosos com diagnóstico confirmado precisam permanecer sem acompanhante. Considerações finais: percebemos que nossa formação propicia condições de analisar de forma sensível as situações vividas pelos pacientes idosos que, neste momento de pandemia, demandam cuidados de enfermagem complexos e suporte biopsicossocial e espiritual, dada a gravidade da doença e a necessidade de isolamento destes pacientes.
Relato de experiência: construção de material audiovisual como ferramenta de capacitação na Atenção Primária à Saúde durante a pandemia de Covid-19
Authors: Costa Giovanna Águila da , Braga Johrdy Amilton da Costa , Prestes Yandra Alves , Barroso Lunna Nascimento , Silva Tatiana Araújo da , Dantas Ellem Nara Tananta , Leon Elisa Brosina de , Campos Hércules Lázaro Morais
Published: November 2023

As tecnologias educacionais podem ser utilizadas como instrumentos para disseminar informação em período de isolamento social. A pesquisa buscou descrever a experiência de produzir vídeos de avaliação cognitiva para pessoas idosastendidas na Atenção Primária à Saúde. Método: Trata-se de um relato de experiência sobre a produção de vídeos animados contendo informações a respeito da utilização de instrumentos de avaliação cognitiva em idosos na Atenção Primária à Saúde do município de Coari-AM. Resultados: Os vídeos foram confeccionados e distribuídos para os gestores das Unidade Básicas de Saúde. Foram abordados um total de 13 gestores que tiveram acesso ao material produzido. Conclusão: A produção e divulgação dos vídeos de avaliação cognitiva em idosos possibilitou a educação continuada de maneira remota entre os gestores.
Efficient catalysts based on substitutional solid solutions and intermetallic compounds of palladium for acetylene selective hydrogenation to ethylene
Authors: Shlyapin D. A. , Yurpalova D. V. , Afonasenko T. N. , Temerev V. L. , Lavrenov A. V.
Published: November 2023

The features of the catalytic action of bimetals such as Pd-Ag, Pd-Cu, Pd-Au, Pd-Ga, Pd-Zn on the conversion of acetylene to ethylene are considered. Two factors that determine the influence of the second metal on palladium – the ensemble effect (geometric effect) and the ligand effect (electronic effect) were taken into account. The relationship between the parameters obtained using calculation methods and experimentally established characteristics are shown. The calculated parameters are thermodynamic and kinetic parameters of the adsorption interaction of the main components of the reaction medium and intermediates with the catalyst surface, the structure of active ensembles and the experimental ones are the structural parameters of bimetallic phases, the electronic state of their components, and catalytic properties of bimetals. The examples illustrating the possibility of the modifier atoms entering into active ensembles and the participation of the sites formed from modifier atoms in the catalysis of individual elementary stages are presented.
Creation of atrial communication in patients with pulmonary hypertension: from balloon atrioseptostomy to atrial flow regulator
Authors: Gorbatykh A. V. , Manannikov D. A. , Lening K. S. , Prokhorikhin A. A. , Zubarev D. D. , Chernyavskiy M. A. , Goncharova N. S. , Moiseeva O. M.
Published: November 2023

Pulmonary hypertension (PH) affects about 1 % of the world’s population, with a three-year survival rate of 70 %. The pathogenetic causes of death are the remodeling of the pulmonary arteries (PA) and the development of right ventricular heart failure (HF), therefore, the main goal of the treatment of pulmonary arterial hypertension (PAH) is to relieve the right chambers of the heart by reducing the pressure in the PA. For this purpose, it is possible to prescribe specific drug therapy to the patient, and in severe cases, surgical intervention — lung transplantation or cardiopulmonary organ complex. However, recently, due to the development and improvement of endovascular methods of treatment of PH, palliative endovascular interventions on the atrial septum are increasingly used, which have undergone significant changes over the past decades. This article presents a literature review of all currently available palliative X-ray endovascular methods for the treatment of PAH, as well as PH developed in patients with left ventricular HF. Objective. The purpose of the review is to assess the role of X-ray endovascular intervention in the treatment of PH.
Exploring Educotourism Through Eco-Literacy in English Learning Materials in MTs Sumber Bungur
Authors: Muqoddas Najwa , Mulyadi
Published: November 2023

Some external factors affect the education system on the macro, including ideology, economy, politics, socio-culture, and natural environment. These factors affect each other in the educational system, including the interaction with the social and natural environment in the broader ecosystem. Eco-literacy should become the curriculum's main focus to face severe environmental problems in the future. The students' ecological intelligence can be grown through understanding the environment and how to be environmentally friendly. This study aims to investigate eco-literacy through English learning materials in terms of educotourism. This research applied the qualitative research method. The data showed in descriptive method because it needed to describe the eco-literacy in English learning materials in MTs Sumber Bungur Pakong regarding educotourism. Meanwhile, the data was collected from observations, interviews, and documentation in MTs Sumber Bungur Pakong. The research results showed the implementation of educotourism through eco-literacy in English earning materials in MTs Sumber Bungur Pakong by founding a syllabus design called ATP related to eco-literacy made by the school of MTs Sumber Bungur Pakong. The syllabus design existed two materials attached to eco-literacy are learned: obligations, prohibitions, and suggestions. Besides, the researcher also found the advantages and disadvantages in making the students aware of keeping the environment
The Utilization of Digital Technologies in Learning Speaking Skills: Students’ Problems and Strategies at Islamic School
Authors: Kameswara Putri Andini , Nashruddin Wakhid , Priajana Nana
Published: November 2023

Effective communication through speaking is a crucial element in today's globalized world. As technology continues to advance, it is essential to incorporate digital tools to enhance and teach speaking skills. An analysis was conducted to investigate the challenges encountered by students while learning English speaking skills through the utilization of digital technologies at an Islamic High School. The study employed a case study methodology with questionnaires and in-depth interviews as data-gathering techniques. The outcomes of this research focused on the student's learning process of English speaking skills, the obstacles they encounter, and the strategies employed to optimize the use of digital technology in acquiring those skills. The demand for curriculum updates and teacher training may contribute to this trend. Urgent changes are needed in English learning to emphasize broader skill development instead of memorizing vocabulary and grammar. Educational institutions should consider these findings and improve English language instruction accordingly.
COVİD-19 Pandemi Sürecinde Gelişimsel Yetersizliği Olan Çocuğa Sahip Annelerin Gereksinimleri, Öz Yeterlikleri ve Tükenmişlik Düzeylerinin İncelenmesi
Authors: SERÇE Aslıcan , DİKEN İbrahim Halil , GÜNDEN Uğur Onur
Published: November 2023

Bu çalışmanın amacı, 0-6 yaş döneminde gelişimsel yetersizliği olan çocuğa sahip annelerin COVİD-19 sürecinde, gereksinimlerini, öz yeterliklerini ve tükenmişlik düzeylerini incelemektir. Çalışma grubunu 87 gelişimsel yetersizliği olan çocuğa sahip annenin oluşturduğu bu araştırma, betimsel-ilişkisel tarama modeli ile desenlenmiştir. Veriler; Aile Gereksinimleri Belirleme Aracı (AGBA), Ebeveyn Öz Yeterlik Ölçeği (EÖYÖ), Anne-Baba Tükenmişlik Ölçeği (ATÖ) ve kişisel bilgi formu ile toplanmıştır. Araştırma sonucunda, annelerin gereksinimi ve tükenmişlik düzeylerinin orta, öz yeterliklerinin yüksek düzeyde olduğu bulgularına ulaşılmıştır. Ayrıca, annelerin gereksinimleri ile tükenmişliği arasında pozitif, öz yeterliği ile gereksinimi arasında negatif ve annelerin tükenmişlik düzeyi ile öz yeterliği arasında negatif yönlü anlamlı bir ilişki bulunmuştur. Çocukların yetersizlik türü ile annelerin gereksinimleri, öz yeterliği ve tükenmişlik düzeylerinin farklılaşmadığı görülmüştür. Bulgular alanyazın ile desteklenerek tartışılmış ve öneriler geliştirilmiştir.
Pharmacovigilance of gene therapy medicinal products
Authors: Petitpain Nadine , Antoine Marie Lauren , Beurrier Mathilde , Micallef Joelle , Fresse Audrey
Published: November 2023

Gene therapy medicinal products (GTMPs) may generate unexpected risks to public health and individual patients. Pharmacovigilance serves the purpose of detecting, assessing, understanding, and preventing adverse effects or any other medicine-related problems. This article aims to provide an overview of the significance of pharmacovigilance and particularities in the domain of gene therapy with a brief description of the European regulatory framework. Viral vectors, insertional mutagenesis, viral latency or reactivation, as well as duration and accuracy of the patient’s clinical follow-up, are some of the main concerns. Two recent examples of signals illustrate some of these safety issues. The first concerns onasemnogene abeparvovec, an adeno-associated virus-based gene replacement therapy for treating spinal muscular atrophy. This GTMP initially raised safety concerns about hepatotoxicity, cardiotoxicity, and neurotoxicity, necessitating recommendations for close monitoring. During the post-marketing period, two fatal cases of acute liver failure led the European Medicine Agency (EMA) to strengthen the recommendations for liver function monitoring. The second example pertains to betibeglogene autotemcel, a genetically modified autologous CD34+ cell-enriched population that contains hematopoietic stem cells transduced with lentiviral vectors encoding the β A-T87Q-globin gene. After the report of a case of acute myeloid leukemia in a patient treated with an investigational product using the same lentiviral vector, the European Commission triggered a regulatory safety procedure. After careful assessment, the EMA’s ad hoc safety committees stated that the viral vector was unlikely to be the cause. However, due to commercial reasons, betibeglogene autotemcel was finally withdrawn from the market by the marketing authorization holder. Pharmacovigilance activities and systems continuously evolve to keep pace with advancements in new therapies and technologies. They must also address varied situations and adhere to evolving regulations. GTMPs likely stand out as one of the most demanding areas within pharmacovigilance. Therefore, their effective oversight requires the full commitment of pharmacological and clinical experts, as well as active involvement from patients, to ensure optimal outcomes.
The Role of Awareness of Consequences in Predicting the Local Tourist’s Plastic Waste Reduction Behavioral Intention: The Extension of Planned Behavior Theory
Authors: Adelazim Ahmed Tarek Sayed , Badawi Adel Nasser , Alotaibi Eid Kaadan , Abbas Ihab Saad , Ali Ehab Rabee
Published: November 2023

This article's goal is to investigate the structural model that explains how awareness of consequences, subjective norms, attitude and behavior control variables influence plastic wastes behavioral intention in Jeddah's beaches, Saudi Arabia. A quantitative approach was employed. For data analysis, structural equation modeling was used. Based on the literature analysis, the study used a structured questionnaire. Multiple statistical analyses were used to examine the hypotheses. This study conducts a survey on a sample of 390 local tourists to investigate their intention to reduce plastic wastes. To increase the explaining power for behavioral intention, this study extended the TPB by adding awareness of consequences. The study's participants were selected randomly. 340 of them agreed and answered the questionnaire, yielding a percentage response rate 87%. This produced 271 valid questionnaires for data analysis after closely examining the survey. The results demonstrate a positive influence of subjective norms, perceived behavioral control, and consequences awareness on environmental behavioral intention. On the other hand, attitude does not significantly contribute to predict EBI. Governments, legislators, and researchers may use the work's findings to create and execute efficient waste management programs.
Local Wisdom-Based Water Resources Conservation: Enhancing Local Wisdom in Society 5.0
Authors: Aspan Zulkifli , Widodo Ernu , Jurdi Fajlurrahman , Jundiani Jundiani
Published: November 2023

Local wisdom as capital for sustainable water resource conservation is becoming increasingly important in the era of Society 5.0. It is characterized by technological transformation and extensive interconnection. In this context, implementing local wisdom values in the conservation of water resources is a significant challenge. This paper discusses the challenges faced in conserving sustainable local wisdom-based water resources in the era of Society 5.0, such as cultural and technological changes. This paper also examines legal regulations in water resource conservation based on local wisdom, such as how laws regulate water use and budget arrangements for water resource conservation. The method used is a literature study of several legal materials using concept and statutory approaches, then analyzed to answer the problems studied. The results show that it is necessary to strengthen the recognition and protection of local wisdom through the preparation or revision of laws and regulations that recognize the values of local wisdom in the conservation of water resources, a collaboration between stakeholders to build citizen communication and consultation; and regulatory adjustments to support the conservation of water resources in the era of society 5.0.
Robert Grosseteste and the Fluid History of the Latin 'Nicomachean Ethics'
Authors: Beullens Pieter
Published: November 2023

This article presents the history of the medieval Latin translations of Aristotle’s Nicomachean Ethics. It features the names of some key figures of the period like Burgundio of Pisa, Robert Grosseteste, and William of Moerbeke. The main focus lies on the question whether Robert Grosseteste had access to a complete copy of the earlier translation by Burgundio of Pisa, or only to the fragmentary version that has come down to us.
To reach an answer, the Latin versions and their Greek models are studied as “fluid texts”, which indicates that all individual witnesses of the text and of its translations contain readings and variants that differentiate them from each other and from the translator’s ultimate intentions. In their turn, the fluid elements cause changes to persist throughout the transmission process and continue to exert mutual influence.
A detailed, though necessarily largely incomplete study of some of these aspects leads to unnoticed evidence and to an uncertain but optimistic conclusion.
Introduction to Robert Grosseteste and Aristotelianism
Authors: Panti Cecilia
Published: November 2023

-
Cenoz, J. & Gorter, D. (2021). Pedagogical Translanguaging. Cambridge University Press.
Authors: Shoecraft Kelly
Published: November 2023

Book review
Vinogradova, P., & Shin, J. K. (Eds.) (2021). Contemporary foundations for teaching English as an additional language: Pedagogical approaches and classroom applications
Authors: Nurlaily Nurlaily
Published: November 2023

Book review
Acknowledgement of Country
Authors: Journal Coordinator TESOL in Context
Published: November 2023

N/A
About TESOL in Context
Authors: Journal Coordinator TESOL in Context
Published: November 2023

N/A
Commercialisation in Australian public education and its implications for the delivery of English as an Additional Language/Dialect: An EAL/D teacher perspective
Authors: Creagh Sue , Playsted Skye , Hogan Anna , Choi Tae-Hee , Lingard Bob
Published: November 2023

Privatisation and commercialisation in education encompass a range of interrelated practices, including the outsourcing of educational services as well as increased reliance on commercially produced resources for the delivery of learning and assessment.  An increase in these practices has accompanied the shift from centralised systemic management of schools and specific programs like English as an Additional Language/Dialect (EAL/D), to school autonomy whereby principals control budget expenditure decisions, ostensibly in response to the needs of their school population. The intersection between school autonomy, commercialisation and delivery of the specialised service of EAL/D is the focus of this paper.  This paper presents the findings of a survey with EAL/D teachers in Australia, in relation to the extent to which they are experiencing commercialisation and the impact this is having on the delivery of a longstanding service designed to ensure equity of outcomes for English language learners. The data suggests that the use of commercial products in schools may not be aligned with appropriate educational practices which target language learning needs. There is a strong need for further research in the uptake and use of commercial products for specialist language support. This will elucidate the extent to which EAL/D as a specialisation is being impacted by the use of commercial products both in the appropriacy of the products and in the deprofessionalisation of specialist EAL/D teachers.
Conversion of Waste Surgical Mask Into Energy Rich Oil by Pyrolysis Using Fly Ash as Catalyst
Authors: D RajaKullayappa , G Karthikeyan , P Premkumar , V Elangkathir
Published: November 2023

Waste mask has been subjected to catalytic pyrolysis. Fly ash used as catalyst. Biogas, formed by the degradation of food waste, is used as the heating agent. Optimum conditions for pyrolysis were determined by the TGA and DTA analysis of the mask. Waste mask was completely converted into oil and gaseous products. The fraction after distillation is the high boiling fraction. By this, the physical properties of both fractions have been determined using standard methods. The physical characteristics of both the low and high boiling fractions are almost very similar to that of petrol and diesel respectively. Both fractions were subjected recorded analysis the GCMS. 1H ,13C NMR and IR spectra were recorded for both fractions. Elemental analysis was carried out for the mask and both oil fractions. GCMS analysis shows that the low boiling fraction contains thirteen 1-alkenes with 8–12 carbon atoms and three alcohols without a C = C bond. The high boiling fraction was found to contain nine isomeric alkenes with 12 carbon atoms. This fraction was found to also contain seven alcohols without C = C bond. NMR, IR spectra and elemental analysis are in support of this composition.
Incidence of neonatal hypoglycemia: an insight from China
Authors: Huang Rui , Jia Meng , Zhang Yingqi , Li Yunfeng , Moreira Joaquim Paulo , Dsouza Brayal
Published: November 2023

Background
Neonatal hypoglycemia is one of the most common metabolic problems in newborns, which can lead to brain damage and increase the risk of developmental delay. The aim of this study was to determine the incidence of neonatal hypoglycemia in neonates and to identify associated risk factors using data from one major hospital in one Province of China.
Methods
Case control study was used on newborns who gave birth between 2016 and 2021 in China. Authors developed a case-control study at a tertiary hospital database between Jan 1, 2016 and Jan 2021. The Cases were identified on the basis of having an outcome of hypoglycemia. Four controls per case (1:4) were randomly selected. Then, multivariable logistic regression analysis was used to analyze risk factors related to the incidence of neonatal hypoglycemia.
Results
16.8% (255) newborns in the cohort had hypoglycemia within 24 hours of birth. Besides, logistic regression analyses showed that cesarean section (OR:3.800,95%CI:8.223–23.158), maternal diabetes(OR:7.416,95%CI:4.287–12.828), maternal hypertension(OR:8.019,95%CI:3.933–16.348), small for gestational age (OR:3.894,95%CI:1.428–10.622), neonatal hypothermia(OR:17.130,95%CI:10.899–26.925) and neonatal infection(OR:17.038,95%CI:5.520–52.590) were risk factors for neonatal hypoglycemia.
Conclusion
In a contemporary cohort in China, the incidence of neonatal hypoglycemia can be considered high, and the incidence of neonatal hypoglycemia is significantly correlated with various clinical factors. Monitoring these risk factors has to be one of the key measures to reduce the adverse consequences caused by neonatal hypoglycemia.
Aggregation of Experts Judgments for Climate Tipping Points
Authors: Basili Marcello , Crudu Federico
Published: November 2023

This paper introduces a method for the evaluation of the occurrence of tipping points based on the combination of probability intervals from experts judgments elicited in face-to-face interviews. The computation of such conditional probabilities is based on the aggregation of imprecise probability judgments through the Steiner point. The probability of a tipping point can be updated by the standard Bayes rule to generate tipping point scenarios. Our results suggest that tipping events may happen with relatively large probabilities, in contrast with the view that tipping points are low-probability-high-impact events. This suggests that mitigation and containment policies cannot be further postponed.
JEL Classification: Q54; D81; C10
Gender- and Age-Stratified Aedes Mosquito Rising and Dengue Burden During COVID- 19 Pandemic in Saudi Arabia
Authors: Alnazawi Ashwaq
Published: November 2023

Background
COVID-19 pandemic led to unprecedented healthcare gaps and challenges linked to COVID-19 pandemic induced constraint on domestic mosquito vector and vector control programs leading to increase in vector-borne diseases public health burden. The study evaluate gender and age linked the increasing Aedes mosquito vector and Dengue virus fitness during COVID-19 pandemic response, in order to provide evidence-based policy decision and priority on integrated vector-borne diseases management with COVID-19 response interventions in Jeddah municipalities, Saudi Arabia.
Methods
A cross-sectional, retro/prospective and analytic increase mosquito risk factors and cases prevalence study was conducted to guide ongoing field mosquito surveillance and integrated vector control interventions during and post COVID-19 response and recovery interventions in Jeddah municipalities, Saudi Arabia
Results
There were marked but not statistically significant fluctuations in the number of monthly confirmed dengue cases during both periods. The highest number of monthly confirmed cases before the pandemic was reported in June 2019 (205 cases) and January 2019 (247 points). Similarly, the first peak during the pandemic was recorded in June 2020 (274 cases), whereas the highest number was documented in April 2021 (311 cases). Monthly gender-based trend of dengue cases before and during the COVID-19 pandemic showed that males were the most affected over the study period as compared to the females. During Covid-19, the trend is increasing with peak over 150 cases in June 2020 and April/May 2021during COVID-19. Age-stratified variations of dengue cases reveals that more cases were during the age range of 15–45 and few above 45 years old with peak precovid recorded in June and December 2019 with over 150 cases recorded. We documented a rise in dengue cases amongst local Saudi with a surge from April to the peak over 100 dengue cases in July 2020, but lesser that non Saudi cases with a surge during the same period and peak over 170 dengue cases in 2020.
Conclusions
To the best of our knowledge, this is the first study documented on the impact of gender and age linked the increasing Aedes mosquito vector and Dengue virus fitness during COVID-19 pandemic response interventions in Saudi Arabia. There is an urgent need to harnessing evidence-decisions on integrated vector-borne diseases surveillance and integrated vector management policies, with COVID-19 response interventions including vaccination coverage and effectiveness in Jeddah municipalities, Saudi Arabia
Formulation and Evaluation of Lipid-Based Nano Formulation of Luliconazole
Authors: Sinhal Amit Pravin Sinhal , Wagh Rajendra D. Wagh
Published: November 2023

The Preformulation study of Luliconazole elucidated its properties and optimization for a self-Nanoemulsifying drug delivery system (SNEDDS). Luliconazole, a tasteless, odorless white powder, exhibited diverse crystalline forms with a melting point of 153.6°C. Notably, it demonstrated high solubility in Oleic Acid and Isopropyl Myristate, corroborated by partition coefficients of 2.80 in n-octanol. UV spectroscopy validated its reliability for analysis, exhibiting a linear standard curve (Y = 0.1013x) with R2 = 0.9988 at 261 nm. The FTIR spectra of Luliconazole and excipients (Isopropyl Myristate, Oleic Acid, Tween 80, and PEG 400) highlighted compatibility crucial for SNEDDS formulation, showcasing distinctive peaks at specific wave numbers. A 32-factorial design optimized IS5 batches, enhancing efficacy and stability through water dilutions (1:1). Thermal analysis, including DSC and XRD, revealed distinct thermal behaviors and crystalline structures, crucial for understanding formulation interactions. The SNEDDS exhibited increased viscosity due to the surfactant, promoting prolonged surface retention and demonstrating significant inhibition of Candida albicans growth, quantified in Table 12 and Fig. 21. In vitro release testing displayed sustained drug liberation in STF (pH 7.4), showcasing diverse kinetics. Entrapment efficiency in IS-4 reached 74 ± 0.8%, ensuring stability (1.54 ± 0.008) vital for emulsification and drug release behavior. HPLC analysis in an ex-vivo permeation study identified a single peak at 6.59 minutes in IS-5, showcasing skin permeation and bloodstream entry, indicating potential bioavailability for fungal infections. The stability study confirmed IS-5's consistent effectiveness, purity, and potency across varied conditions (4°C, 25°C, 40°C; 15%, 65%, 75% RH), crucial for ensuring a reliable and enduring product. Additionally, skin irritation studies validated IS-5's safety for transdermal drug delivery, essential for patient comfort in pharmaceutical applications.
Characterization of nodulation capacity with native rhizobia in germplasm of underutilized forage species of Macroptilium (Benth.) Urb.
Authors: Zabala Juan Marcelo , Marinoni Lorena del Rosario , Zuber Nicolas , Fornasero Laura , Pensiero Jose Francisco
Published: November 2023

In order to generate reliable characterization and selection schemes in germplasm of Macroptilium for biological nitrogen fixation with native rhizobia, we carried out a trial to evaluate the germplasm variability for initial growth, crude protein in shoots and nodulation capacity with native soil of subtropical environment. The trial was carried out under two conditions, substrate with (N+) and without nitrogen added (N-). The growth variables and nitrogen content were analyzed through a nested ANOVA with the factors species (S), accessions nested within species (ANS), nitrogen level (NL) and the corresponding interactions. Because the plants did not nodulate in the N + treatment, a simple one-way ANOVA was performed in the N- treatment to analyze nodulation capacity. Relationships between variables and accessions were examined using principal component analysis. All accessions evaluated formed effective nodules in N- treatment. Accessions showed different initial growth and nitrogen content at different nitrogen levels. There was variability in the symbiotic response and initial growth, and most of the variance was explained by differences between ANS. Nodule number and nodule weight were related to Macroptilium plant dry matter and crude protein in shoots. Our hypotheses were confirmed in this work. In evaluated germplasm we found variability for nodulation capacity. In the other hand, nodulation capacity was related with biological nitrogen fixation (BNF), since the accessions with higher NC showed higher initial growth and higher protein content in shoot.