bluuebunny/crossref_metadata_2025 huggingface dataset:
Enhancing emotion regulation with an in situ socially assistive robot among LGBTQ+ youth with self-harm ideation: protocol for a randomised controlled trial
Authors: Williams A Jess , Cleare Seonaid , Borschmann Rohan , Tench Christopher R , Gross James , Hollis Chris , Chapman-Nisar Amelia , Naeche Nkem , Townsend Ellen , Slovak Petr
Published: January 2024

Introduction

Purrble, a socially assistive robot, was codesigned with children to support in situ emotion regulation. Preliminary evidence has found that LGBTQ+ youth are receptive to Purrble and find it to be an acceptable intervention to assist with emotion dysregulation and their experiences of self-harm. The present study is designed to evaluate the impact of access to Purrble among LGBTQ+ youth who have self-harmful thoughts, when compared with waitlist controls.

Methods and analysis

The study is a single-blind, randomised control trial comparing access to the Purrble robot with waitlist control. A total of 168 LGBTQ+ youth aged 16–25 years with current self-harmful ideation will be recruited, all based within the UK. The primary outcome is emotion dysregulation (Difficulties with Emotion Regulation Scale-8) measured weekly across a 13-week period, including three pre-deployment timepoints. Secondary outcomes include self-harm (Self-Harm Questionnaire), anxiety (Generalised Anxiety Disorder-7) and depression (Patient Health Questionnaire-9). We will conduct analyses using linear mixed models to assess primary and secondary hypotheses. Intervention participants will have unlimited access to Purrble over the deployment period, which can be used as much or as little as they like. After all assessments, control participants will receive their Purrble, with all participants keeping the robot after the end of the study. After the study has ended, a subset of participants will be invited to participate in semistructured interviews to explore engagement and appropriation of Purrble, considering the young people’s own views of Purrble as an intervention device.

Ethics and dissemination

Ethical approval was received from King’s College London (RESCM-22/23-34570). Findings will be disseminated in peer review open access journals and at academic conferences.

Trial registration number

NCT06025942.
Effects of the enhanced recovery after surgery intervention for preventing postpartum depression: a protocol for systematic review and meta-analysis
Authors: Yang Chenchen , Chen Kai , Zhang Peipei , Xue Mei , Li Hui
Published: January 2024

Introduction

Postpartum depression (PPD), a prevalent public health problem, is a debilitating mental disorder for which preventive interventions could yield dramatic benefits. However, viable approach focusing the prevention of PPD for caesarean section (CS) patients remains limited currently. In recent decades, enhanced recovery after surgery (ERAS) has gradually been implemented in CS and appears to be a potential and favourable preventive intervention for PPD, but systematic evidence on this issue is lacking. Therefore, a meta-analysis is designed to systematically explore the potential effect of ERAS on the prevention of PPD in CS patients.

Methods and analysis

Meta-analysis will be performed according to the Preferred Reporting Items for Systematic Review and Meta-Analyses statement. A systematic search across the PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure, Chinese Biomedical Literature Database, Chinese Scientific Journal Database, grey literature and Wanfang Database will be conducted from inception to July 2023. Relevant studies investigating the association between ERAS and PPD will be included. Two reviewers will independently carry out the literature selection, data extraction and risk of bias assessment. Disagreements will be resolved by group consensus. Statistical analyses will use the RevMan V.5.3 and STATA V.13 software. The Grading of Recommendations Assessment, Development, and Evaluation system will be used to evaluate the strength of evidence.

Ethics and dissemination

This study raises no ethical issues. The pending meta-analysis may provide reliable evidence supporting ERAS as a viable preventive option for PPD in CS patients, further providing a useful reference for the health authorities and promoting the future clinical practice in this field. The formal results of this study will be submitted to a professional journal for publication.

PROSPERO registration number

CRD42023485929.
Where are the inequalities in colorectal cancer care in a country with universal healthcare? A systematic review and narrative synthesis
Authors: Pickwell-Smith Benjamin Alexander , Spencer Katie , Sadeghi Mahboobeh Haji , Greenley Sarah , Lind Michael , Macleod Una
Published: January 2024

Objective

Patients diagnosed with colorectal cancer living in more deprived areas experience worse survival than those in more affluent areas. Those living in more deprived areas face barriers to accessing timely, quality healthcare. These barriers may contribute to socioeconomic inequalities in survival. We evaluated the literature for any association between socioeconomic group, hospital delay and treatments received among patients with colorectal cancer in the UK, a country with universal healthcare.

Design

MEDLINE, EMBASE, CINAHL, CENTRAL, SCIE, AMED and PsycINFO were searched from inception to January 2023. Grey literature, including HMIC, BASE and Google Advanced Search, and forward and backward citation searches were conducted. Two reviewers independently reviewed titles, abstracts and full-text articles. Observational UK-based studies were included if they reported socioeconomic measures and an association with either hospital delay or treatments received. The QUIPS tool assessed bias risk, and a narrative synthesis was conducted. The review is reported to Preferred Reporting Items for Systematic Reviews and Meta-Analyses 2020.

Results

41 of the 7209 identified references were included. 12 studies evaluated 7 different hospital intervals. There was a significant association between area-level deprivation and a longer time from first presentation in primary care to diagnosis. 32 studies evaluated treatments received. There were socioeconomic inequalities in surgery and chemotherapy but not radiotherapy.

Conclusion

Patients with colorectal cancer face inequalities across the cancer care continuum. Further research is needed to understand why and what evidence-based actions can reduce these inequalities in treatment. Qualitative research of patients and clinicians conducted across various settings would provide a rich understanding of the complex factors that drive these inequalities. Further research should also consider using a causal approach to future studies to considerably strengthen the interpretation. Clinicians can try and mitigate some potential causes of colorectal cancer inequalities, including signposting to financial advice and patient transport schemes.

PROSPERO registration number

CRD42022347652.
Associations between dry eye disease and sleep quality: a cross-sectional analysis
Authors: Ayoubi Mohammad , Cabrera Kimberly , Mangwani-Mordani Simran , Locatelli Elyana Vittoria Tessa , Galor Anat
Published: January 2024

Background/aims

To investigate relationships between dry eye (DE) disease and sleep quality, with a focus on which aspects of sleep most closely relate to DE.

Methods

141 veterans (mean age: 56±5) seen at the Miami Veterans Affairs eye clinic filled out questionnaires to quantify the severity of DE symptoms (5-Item Dry Eye Questionnaire (DEQ-5) and Ocular Surface Disease Index (OSDI)) and ocular pain (Numerical Rating Scale (NRS) and Neuropathic Pain Symptom Inventory modified for the Eye (NPSI-E)). All individuals also underwent an ocular surface examination. Aspects of sleep quality were assessed using the Pittsburgh Sleep Quality Index (PSQI). DE metrics were examined by PSQI scores and subscores.

Results

Most participants (76%) reported mild or greater DE symptoms (DEQ-5 ≥6). Overall, ocular symptoms were more related to sleep metrics than signs. The strongest DE symptom association was between the OSDI and sleep disturbances (PSQI subscore 5, r=0.49, p<0.0005). For DE signs, ocular surface inflammation and meibum quality were related to subjective sleep quality (PSQI subscore 1, r=0.29, p=0.03, for both). On linear regression analyses, most ocular symptom questionnaires remained associated with sleep disturbances (PSQI subscore 5: NRS (r=0.52, p<0.0005), DEQ-5 (r=0.36, p<0.0005), and OSDI (r=0.31, p<0.0005)). For DE signs, ocular surface inflammation and meibum quality remained associated with subjective sleep quality (r=0.26, p=0.01; r=0.46, p<0.0005, respectively).

Conclusion

DE symptom and ocular pain intensity were closely related to sleep metrics, most strongly to sleep disturbances. Relationships were weaker for DE signs, with subjective sleep quality relating to inflammation and meibum quality.
Advancing health equity in improving breast cancer screening with the use of a mobile mammography bus in marginalised population: quality improvement project
Authors: Bakhai Smita , Ansari Mohammad , Sadeghi Cirous , Reynolds Jessica L
Published: January 2024

Background

Breast cancer, the second leading cause of cancer-related deaths in women in the USA, is effectively treated through early detection and screening. This quality improvement (QI) project aimed to improve mammography screening rates from the baseline of 50% to 60% within 12 months for patients aged 50–74 years at an Internal Medicine Clinic.

Methods

We used the Plan, Do, Study, Act (PDSA) model. A multidisciplinary team used a fishbone diagram to identify barriers to suboptimal screening. The QI team created a driver diagram and process flow map. The mammogram screening rate was the outcome measure. Mammogram order and completion rates were the process measures. We implemented six PDSA cycles. Major interventions included the use of a nurse navigator, enhancements in health information technology, and education to patients, providers, and nursing staff. Mammograms were offered in a mobile bus, located in the hospital campus and in under-resourced inner-city neighbourhoods to improve the access. Data analysis was performed using monthly statistical process control charts.

Results

The project exceeded its initial goal, achieving a breast cancer screening rate of 66% (n=490 of 744) during the study period and was sustainable at 69%, 3 months post-project. The mammogram order rate was 58% (n=432 of 744) and completion rate was 53% (n=231 of 432) within 12 months.

Conclusions

We attributed the success of this QI project to the education of patients, nurses and physicians, the use of a nurse navigator and engagement of a multidisciplinary team. Access to mobile mammography bus addressed the social determinants of health barriers in a marginalised population.
Decision-maker roles in healthcare quality improvement projects: a scoping review
Authors: Gagnon Justin , Breton Mylaine , Gaboury Isabelle
Published: January 2024

Objectives

Evidence suggests that healthcare quality improvement (QI) projects are more successful when decision-makers are involved in the process. However, guidance regarding the engagement of decision-makers in QI projects is lacking. We conducted a scoping review to identify QI projects involving decision-makers published in the literature and to describe the roles decision-makers played.

Methods

Following the Joanna Briggs Institute framework for scoping reviews, we systematically searched for all types of studies in English or French between 2002 and 2023 in: EMBASE, MEDLINE via PubMed, PsycINFO, and the Cumulative Index to Nursing and Allied Health Literature. Criteria for inclusion consisted of literature describing health sector QI projects that involved local, regional or system-level decision-makers. Descriptive analysis was performed. Drawing on QI and participatory research literature, the research team developed an inductive data extraction grid to provide a portrait of QI project characteristics, decision-makers’ contributions, and advantages and challenges associated with their involvement.

Results

After screening and review, we retained 29 references. 18 references described multi-site projects and 11 were conducted in single sites. Local decision-makers’ contributions were documented in 27 of the 29 references and regional decision-makers’ contributions were documented in 12. Local decision-makers were more often active participants in QI processes, contributing toward planning, implementation, change management and capacity building. Regional decision-makers more often served as initiators and supporters of QI projects, contributing toward strategic planning, recruitment, delegation, coordination of local teams, as well as assessment and capacity building. Advantages of decision-maker involvement described in the retained references include mutual learning, frontline staff buy-in, accountability, resource allocation, effective leadership and improved implementation feasibility. Considerations regarding their involvement included time constraints, variable supervisory expertise, issues concerning centralised leadership, relationship strengthening among stakeholders, and strategic alignment of frontline staff and managerial priorities

Conclusions

This scoping review provides important insights into the various roles played by decision-makers, the benefits and challenges associated with their involvement, and identifies opportunities for strengthening their engagement. The results of this review highlight the need for practical collaboration and communication strategies that foster partnership between frontline staff and decision-makers at all levels.
Presentation, characteristics and management of obstructive intestinal conditions in cystic fibrosis
Authors: Miles Caitlin , Ling Natalie , Paul Eldho , Armstrong David
Published: January 2024

Objective

Constipation and distal intestinal obstruction syndrome (DIOS) are common gastrointestinal manifestations of cystic fibrosis (CF). The primary aim was to describe the characteristics of constipation and DIOS hospitalisations in a paediatric and adult CF service over a 12-year period. The secondary aims were to determine the proportion of constipation and DIOS presentations which met the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) CF Working Group definitions and to describe management strategies of both conditions.

Method

A retrospective study of children and adults with CF who were admitted with a primary diagnosis of constipation or DIOS between 1 January 2011 and 31 December 2022. ESPGHAN definitions for constipation and DIOS were retrospectively applied to all admissions to determine if the primary medical diagnosis met ESPGHAN criteria.

Results

During the 12-year study period, 42 hospitalisations for constipation were recorded in 19 patients, and 33 hospitalisations for DIOS were recorded in 23 patients. 88.10% of constipation episodes met ESPGHAN definitions, compared with 3.0% of DIOS episodes. Constipation and DIOS were primarily treated with polyethylene glycol (PEG). The use of sodium amidotrizoate meglumine enemas was significantly higher in the DIOS group (p=0.045). Those admitted with DIOS were significantly less likely to be recommended a weaning dose of PEG (p=0.018).

Conclusion

Children and adults with CF are more commonly admitted for the management of constipation than DIOS. There is considerable variation in diagnostic and therapeutic practice, and this study highlights the need to enhance the translation and adoption of existing best-practice guidelines.
Development of an Actor Rehearsal Guide for Communication Skills Courses
Authors: Lawton Andrew J , Greco Lauren , Airaldi Remo , Tulsky James A
Published: January 2024

Background

Established models of serious illness communication training frequently include role play with simulated patient actors. Yet preparing for communication courses can feel challenging, as most faculty have minimal experience directing actors, and no literature exists to guide faculty in how to lead course rehearsals.

Methods

A team of palliative care educators partnered with a seasoned acting teacher to design and implement a faculty guide for directing actors during communication course rehearsals. Their approach involved a series of brainstorming sessions, creation and piloting of a draft rehearsal guide and revisions based on actor and faculty feedback.

Results

The actor rehearsal guide offers a stepwise approach to beginning a rehearsal, rehearsing a patient case, giving feedback to the actor and ensuring the actor responds appropriately to learners of varied skill levels. From early 2021 to late 2022, the team used the guide to prepare for 36 courses, which trained 446 clinicians. Faculty and actors noted that the guide fostered predictable and efficient rehearsals.

Conclusions

A novel actor rehearsal guide can support preparation for communication courses at a single institution. Next steps include disseminating the guide to other institutions and evaluating the guide’s impact on faculty and actors’ experience of rehearsals and learners’ experience of training.
Low-intensity focused ultrasound stimulation promotes stroke recovery via astrocytic HMGB1 and CAMK2N1 in mice
Authors: Qi Lin , Wang Cheng , Deng Lidong , Pan Jia-Ji , Suo Qian , Wu Shengju , Cai Lin , Shi Xudong , Sun Junfeng , Wang Yongting , Tang Yaohui , Qiu Weibao , Yang Guo-Yuan , Wang Jixian , Zhang Zhijun
Published: January 2024

Background

Low-intensity focused ultrasound stimulation (LIFUS) has been developed to enhance neurological repair and remodelling during the late acute stage of ischaemic stroke in rodents. However, the cellular and molecular mechanisms of neurological repair and remodelling after LIFUS in ischaemic stroke are unclear.

Methods

Ultrasound stimulation was treated in adult male mice 7 days after transient middle cerebral artery occlusion. Angiogenesis was measured by laser speckle imaging and histological analyses. Electromyography and fibre photometry records were used for synaptogenesis. Brain atrophy volume and neurobehaviour were assessed 0–14 days after ischaemia. iTRAQ proteomic analysis was performed to explore the differentially expressed protein. scRNA-seq was used for subcluster analysis of astrocytes. Fluorescence in situ hybridisation and Western blot detected the expression of HMGB1 and CAMK2N1.

Results

Optimal ultrasound stimulation increased cerebral blood flow, and improved neurobehavioural outcomes in ischaemic mice (p<0.05). iTRAQ proteomic analysis revealed that the expression of HMGB1 increased and CAMK2N1 decreased in the ipsilateral hemisphere of the brain at 14 days after focal cerebral ischaemia with ultrasound treatment (p<0.05). scRNA-seq revealed that this expression pattern belonged to a subcluster of astrocytes after LIFUS in the ischaemic brain. LIFUS upregulated HMGB1 expression, accompanied by VEGFA elevation compared with the control group (p<0.05). Inhibition of HMGB1 expression in astrocytes decreased microvessels counts and cerebral blood flow (p<0.05). LIFUS reduced CAMK2N1 expression level, accompanied by increased extracellular calcium ions and glutamatergic synapses (p<0.05). CAMK2N1 overexpression in astrocytes decreased dendritic spines, and aggravated neurobehavioural outcomes (p<0.05).

Conclusion

Our results demonstrated that LIFUS promoted angiogenesis and synaptogenesis after focal cerebral ischaemia by upregulating HMGB1 and downregulating CAMK2N1 in a subcluster of astrocytes, suggesting that LIFUS activated specific astrocyte subcluster could be a key target for ischaemic brain therapy.
Real-world analysis of two ischaemic stroke and TIA systolic blood pressure goals on 12-month mortality and recurrent vascular events
Authors: Sico Jason J , Hu Xin , Myers Laura J , Levine Deborah , Bravata Dawn M , Arling Greg W
Published: January 2024

Introduction

Whether obtaining the more intensive goal systolic blood pressure (SBP) of <130 mm Hg, rather than a less intensive SBP goal of <140 mm Hg poststroke/transient ischaemic attack (TIA) is associated with incremental mortality and recurrent vascular event benefit is largely unexplored using real-world data. Lowering SBP excessively may result in poorer outcomes.

Methods

This is a retrospective cohort study of 26 368 Veterans presenting to a Veterans Administration Medical Center (VAMC) with a stroke/TIA between October 2015 and July 2018. Patients were excluded from the study if they had missing or extreme BP values, receiving dialysis or palliative care, left against medical advice had a cancer diagnosis, were cared for in a VAMC enrolled in a stroke/TIA quality improvement initiative, died or had a cerebrovascular or cardiovascular event within 90 days after their index stroke/TIA. The analytical sample included 12 337 patients. Average SBP during 90 days after discharge was assessed in categories (≤105 mm Hg, 106–115 mm Hg, 116–130 mm Hg, 131–140 mm Hg and >140 mm Hg). Separate multivariable Cox proportional hazard regressions were used to examine the relationship between average SBP groups and time to: (1) mortality and (2) any recurrent vascular event, from 90 days to up to 365 days after discharge from the index emergency department visit or inpatient admission.

Results

Compared with those with SBP>140 mm Hg, patients with SBP between 116 and 130 mm Hg had a significantly lower risk of recurrent stroke/TIA (HR 0.77, 95% CI 0.60 to 0.99) but not cardiovascular events. Patients with SBP lower than 105 mm Hg, compared with those with >140 mm Hg demonstrated a statistically significant higher risk of death (HR 2.07, 95% CI 1.43 to 3.00), but no statistical differences were found in other SBP groups.

Discussion

Data support a more intensive SBP goal to prevent recurrent cerebrovascular events among stroke/TIA patients by 90 days poststroke/TIA compared with less intensive goal. Very low SBPs were associated with increased mortality risk.
On the quantization of FLPR model
Authors: Nair Ansha S. , Gupta Saurabh
Published: January 2024

In this paper, we quantize the Friedberg–Lee–Pang–Ren (FLPR) model, using an admissible gauge condition, within the framework of modified Faddeev–Jackiw formalism. Further, we deduce the gauge symmetries and establish off-shell nilpotent and absolutely anti-commuting (anti-)BRST symmetries. We also show that the physical states of the theory are annihilated by the first class constraints which is consistent à la Dirac formalism.
Enhancement of Optical Properties and Stability in CsPbBr3 Using CQD and TOP Doping for Solar Cell Applications
Authors: Salih Ajaj Chiayee , Sadiq Diyar
Published: January 2024

Cesium lead bromide (CsPbBr3) nanocrystals exhibit remarkable optoelectronic properties and exceptional stability. As a result, they have garnered significant interest for their potential applications in various fields, including solar cells, light-emitting devices, photodetectors, and lasers. Despite its resistance to moisture, oxygen, and heat compared to other perovskite materials, CsPbBr3 still faces challenges maintaining its structural and optical stability over extended periods. This study proposes a robust solution to enhance and improve simultaneously the photoluminescence intensity and stability of CsPbBr3 nanocrystals. The solution involves doping the perovskite precursor with green-synthesized carbon quantum dots (CQDs) and tri-n-octyl phosphine (TOP). The results indicate that the photoluminescence intensity of the perovskite nanocrystals (NCs) is sensitive to varying CQD ratios. A high photoluminescence intensity enhancement of 45% was achieved at the optimal CQDs ratio. The synthesized perovskite NCs/CQDs also demonstrated improved stability by adding TOP into the mixture. After storage in the air for 45 days, the mixed perovskite NCs maintained their performance, which was almost unchanged. Solar cell devices based on the modified perovskite NCs showed a power conversion of 7.74%. The devices also demonstrated a significant open-circuit voltage (VOC), with the most successful device achieving a VOC of 1.193 V, an Isc of 10.5748 mA cm−2, and a fill factor (FF) of 61%. This study introduces a cost-effective method for producing high-quality all-inorganic optoelectronic devices with enhanced performance and stability.
Data from Acquired Resistance to Combination Treatment with Temozolomide and ABT-888 Is Mediated by Both Base Excision Repair and Homologous Recombination DNA Repair Pathways
Authors: Liu Xuesong , Han Edward K. , Anderson Mark , Shi Yan , Semizarov Dimitri , Wang Gang , McGonigal Thomas , Roberts Lisa , Lasko Loren , Palma Joann , Zhu Gui-dong , Penning Thomas , Rosenberg Saul , Giranda Vincent L. , Luo Yan , Leverson Joel , Johnson Eric F. , Shoemaker Alexander R.
Published: January 2024

Abstract
Many established cancer therapies involve DNA-damaging chemotherapy or radiotherapy. Gain of DNA repair capacity of the tumor represents a common mechanism used by cancer cells to survive DNA-damaging therapy. Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme that is activated by DNA damage and plays a critical role in base excision repair. Inhibition of PARP represents an attractive approach for the treatment of cancer. Previously, we have described the discovery and characterization of a potent PARP inhibitor, ABT-888. ABT-888 potentiates the activity of DNA-damaging agents such as temozolomide (TMZ) in a variety of preclinical models. We report here the generation of HCT116 cells resistant to treatment with TMZ and ABT-888 (HCT116R cells). HCT116R cells exhibit decreased H2AX phosphorylation in response to treatment with TMZ and ABT-888 relative to parental HCT116 cells. Microarray and Western blot studies indicate that HCT116R cells have decreased PARP-1 and elevated Rad51 expression levels. HCT116R cells are dependent on Rad51 for proliferation and survival, as shown by inhibition of proliferation and induction of apoptosis upon treatment with Rad51 small interfering RNA. In addition, HCT116R cells are more resistant to radiation than the parental HCT116 cells. Our study suggests that cancer cells upregulate the homologous recombination DNA repair pathway to compensate for the loss of base excision repair, which may account for the observed resistance to treatment with TMZ and ABT-888. (Mol Cancer Res 2009;7(10):1686–92)
Passenger Gene Coamplifications Create Collateral Therapeutic Vulnerabilities in Cancer
Authors: Bei Yi , Bramé Luca , Kirchner Marieluise , Fritsche-Guenther Raphaela , Kunz Severine , Bhattacharya Animesh , Rusu Mara-Camelia , Gürgen Dennis , Dubios Frank P.B. , Köppke Julia K.C. , Proba Jutta , Wittstruck Nadine , Sidorova Olga Alexandra , Chamorro González Rocío , Dorado Garcia Heathcliff , Brückner Lotte , Xu Robin , Giurgiu Mădălina , Rodriguez-Fos Elias , Yu Qinghao , Spanjaard Bastiaan , Koche Richard P. , Schmitt Clemens A. , Schulte Johannes H. , Eggert Angelika , Haase Kerstin , Kirwan Jennifer , Hagemann Anja I.H. , Mertins Philipp , Dörr Jan R. , Henssen Anton G.
Published: January 2024

DNA amplifications in cancer do not only harbor oncogenes. We sought to determine whether passenger coamplifications could create collateral therapeutic vulnerabilities. Through an analysis of >3,000 cancer genomes followed by the interrogation of CRISPR-Cas9 loss-of-function screens across >700 cancer cell lines, we determined that passenger coamplifications are accompanied by distinct dependency profiles. In a proof-of-principle study, we demonstrate that the coamplification of the bona fide passenger gene DEAD-Box Helicase 1 (DDX1) creates an increased dependency on the mTOR pathway. Interaction proteomics identified tricarboxylic acid (TCA) cycle components as previously unrecognized DDX1 interaction partners. Live-cell metabolomics highlighted that this interaction could impair TCA activity, which in turn resulted in enhanced mTORC1 activity. Consequently, genetic and pharmacologic disruption of mTORC1 resulted in pronounced cell death in vitro and in vivo. Thus, structurally linked coamplification of a passenger gene and an oncogene can result in collateral vulnerabilities.

Significance:

We demonstrate that coamplification of passenger genes, which were largely neglected in cancer biology in the past, can create distinct cancer dependencies. Because passenger coamplifications are frequent in cancer, this principle has the potential to expand target discovery in oncology.

This article is featured in Selected Articles from This Issue, p. 384
FIGURE 3 from Analysis of Changes in Plasma Cytokine Levels in Response to IL12 Therapy in Three Clinical Trials
Authors: Schwarz Emily , Benner Brooke , Yu Lianbo , Tounkara Fode , Carson William E.
Published: January 2024

Cytokine fluxes according to patient response group. Changes in each cytokine level (pg/mL) following IL12 therapy were calculated compared with baseline. These changes were then compared between patients with PD and patients experiencing CB. CB is defined as SD, PR, or CR. ANOVA was employed to test differences in cytokine flux between patient response groups. Cytokines shown here were found to have significantly increased changes in PD patients compared with clinically benefitting patients following IL12 therapy. ANOVA, *, P < 0.05.
FIGURE 2 from Analysis of Changes in Plasma Cytokine Levels in Response to IL12 Therapy in Three Clinical Trials
Authors: Schwarz Emily , Benner Brooke , Yu Lianbo , Tounkara Fode , Carson William E.
Published: January 2024

Heat map showing patient (n = 21) plasma levels of 23 cytokines ranging from 0 to 150 pg/mL in A and 0 to 5,000 pg/mL in B. The presence of red coloring represents increasing levels of each cytokine over 0 pg/mL, which is depicted by the color white. Individual patients are categorized by time and response, with the first two columns representing baseline and post-IL12 timepoints of PD patients, the second two columns representing baseline and post-IL12 timepoints of SD patients and the third two columns representing baseline and post-IL12 timepoints of CR/PR patients. Each of the 23 cytokines analyzed are labeled on the y-axis. Averages from each respective subset of patients included are plotted and were measured by multiplex assays. The color gray represents samples unavailable for inclusion.
A presença do mito de Narciso em três sonetos camonianos
Authors: Santos Taynnã de Camargo
Published: January 2024

O presente artigo analisa a presença do mito de Narciso na lírica camoniana, a partir do estudo de três sonetos: “Tanto de meu estado me acho incerto”, “Transforma-se o amador na cousa amada” e “Dizei, Senhora, da Beleza ideia”. Através de uma análise dos elementos presentes nos poemas selecionados e a comparação com os mitemas narcísicos, destacaremos as possíveis alusões ao mito, tanto na associação direta ao seu texto fundador, estabelecido por Ovídio na obra Metamorfoses, quanto em associações indiretas, por exemplo, através de referências à obra de Francesco Petrarca, autor que, assim como Camões, era inspirado pela tradição greco-romana.
Recepção do mito grego-romano em O juramento dos numes (1813), de Gastão Fausto da Camara Coutinho
Authors: Silva Renato Cândido da
Published: January 2024

No início do século XIX, com a transferência da corte portuguesa para o Rio de Janeiro, novos edifícios teatrais foram construídos, a exemplo do Real Teatro de S. João. Na ocasião de sua inauguração, em 1813, foi representado O juramento dos numes, do escritor português Gastão Fausto da Camara Coutinho (1772-1852). Esse libreto, de caráter encomiástico, apresenta diversas referências à mitologia da antiguidade clássica. Assim, este artigo, de cunho bibliográfico, tem por objetivo analisar a referida obra levando em consideração os seguintes aspectos: a recepção do mito greco-romano a partir das personagens Vulcano e Vênus e a relação entre o mito e a história, sobretudo no que diz respeito ao exílio da corte portuguesa no Rio de Janeiro.
Um Satanás pelintra: um exercício de leitura do mito fáustico n’Os Maias, de Eça de Queirós
Authors: Pereira Pedro Martins Cruz de Aguiar
Published: January 2024

A intenção do presente artigo é realizar um exercício de leitura d’Os Maias (2001) [1888], do romancista Eça de Queirós (1845-1900), assim pretende observar como certas características do ‘mito fáustico’ aparecem no decorrer do romance, quais sejam: o desejo pelo conhecimento e a contenda com o saber previamente estabelecido e o controle pelo próprio destino. Assim, o artigo será composto por três partes. Na primeira, apresentar-se-á a trajetória do mito fáustico até a sua recepção em Portugal, no século XIX tendo em vista que o mito fáustico mantém um núcleo duro ao mesmo tempo que se altera conforme o trajeto. Na segunda parte, pretende-se apresentar a aparição, para além do que é visto n’Os Maias. Desse modo, considerar-se-á que o mito pode ser encontrado na crónica “Mefistófeles”, de Prosas Bárbaras [1903] (1912), escrita para o folhetim da Gazeta de Portugal, de 1866 até 1867; e no romance O primo Basílio (1878). Do mesmo modo, ponderar-se-á um pouco sobre a localização d’Os Maias no contexto geral da obra queirosiana, como integrante do projeto literário “Cenas Portuguesas” ou “Cenas da Vida Portuguesa”. Por último, realizar-se-á uma análise de caso da obra de predileção, focando principalmente no primeiro volume do livro que, como foi possível observar, é aquele que traz em suas páginas as representações que consideramos mais pertinentes para uma leitura do mito fáustico. Do arcabouço teórico queirosiano, foi de valia o livro de Izabel Margato, Tiranias da modernidade (2008), e o livro de Sérgio Nazar David, O século de Silvestre da Silva, vol.2: estudos queirosianos (2007). Da mesma forma, os livros Fausto na literatura europeia (1984), organizado por João Barrento, e O olhar de Orfeu (2003), organizado por Bernadette Bricout, foram essenciais para uma ponderação bem fundamentada das bases históricas, literárias e filosóficas do mito fáustico.
Camões e os ingleses: a mitificação da Inglaterra em Os Lusíadas
Authors: Oliveira Luiz Eduardo
Published: January 2024

Este artigo investiga o modo como os ingleses são representados em Os Lusíadas (1572), buscando identificar os motivos e referenciais históricos que levaram Camões a mitificar positivamente a Inglaterra. Para tanto, fazendo uso de alguns pressupostos conceituais referentes ao mito e às representações (Burkert, 1991; Eliade, 2000; Chartier, 2002), buscamos analisar a maneira pela qual tal processo de mitificação, que se inscreve na própria narrativa de origem do reino e do povo português, configura-se discursivamente, na épica camoniana, no lendário episódio dos Doze de Inglaterra. Assim, buscamos mostrar como, ao ressaltar os valores cavaleirescos tão caros à época, o episódio reveste-se de uma funcionalidade política crucial para o reino de Portugal, pois contribui de forma eficaz para o reconhecimento internacional da Casa de Avis.
A reproducible and generalizable software workflow for analysis of large-scale neuroimaging data collections using BIDS Apps
Authors: Zhao Chenying , Jarecka Dorota , Covitz Sydney , Chen Yibei , Eickhoff Simon B. , Fair Damien A. , Franco Alexandre R. , Halchenko Yaroslav O. , Hendrickson Timothy J. , Hoffstaedter Felix , Houghton Audrey , Kiar Gregory , Macdonald Austin , Mehta Kahini , Milham Michael P. , Salo Taylor , Hanke Michael , Ghosh Satrajit S. , Cieslak Matthew , Satterthwaite Theodore D.
Published: January 2024

Neuroimaging research faces a crisis of reproducibility. With massive sample sizes and greater data complexity, this problem becomes more acute. Software that operates on imaging data defined using the Brain Imaging Data Structure (BIDS)—the BIDS App—has provided a substantial advance. However, even using BIDS Apps, a full audit trail of data processing is a necessary prerequisite for fully reproducible research. Obtaining a faithful record of the audit trail is challenging—especially for large datasets. Recently, the FAIRly big framework was introduced as a way to facilitate reproducible processing of large-scale data by leveraging DataLad—a version control system for data management. However, the current implementation of this framework was more of a proof of concept, and could not be immediately reused by other investigators for different use cases. Here, we introduce the BIDS App Bootstrap (BABS), a user-friendly and generalizable Python package for reproducible image processing at scale. BABS facilitates the reproducible application of BIDS Apps to large-scale datasets. Leveraging DataLad and the FAIRly big framework, BABS tracks the full audit trail of data processing in a scalable way by automatically preparing all scripts necessary for data processing and version tracking on high performance computing (HPC) systems. Currently, BABS supports jobs submissions and audits on Sun Grid Engine (SGE) and Slurm HPCs with a parsimonious set of programs. To demonstrate its scalability, we applied BABS to data from the Healthy Brain Network (HBN; n = 2,565). Taken together, BABS allows reproducible and scalable image processing and is broadly extensible via an open-source development model.
Erratum: Li, T., Zhong, G.R., Li, T.H., Deng, W.Q. & Zhang, M. (2024) Amoenoboletus brachysporus (Boletaceae), a new species from Southern China. Phytotaxa 633 (1): 51–59.
Authors: LI TING , ZHONG GUORUI , LI TAIHUI , DENG WANGQIU , ZHANG MING
Published: January 2024

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Morphology and multi-gene phylogeny reveal a new Brunneofusispora species from coffee in Yunnan Province, China
Authors: LIU XIANGFU , TIBPROMMA SAOWALUCK , KARUNARATHNA SAMANTHA C. , CHETHANA K.W.T. , LU LI , DAI DONGQIN , ELGORBAN ABDALLAH M. , HYDE KEVIN D.
Published: January 2024

Coffee is one of the most important cash crops native to north-central Africa, and the second most popular beverage ingredient worldwide. Coffee-associated fungal pathogens have been well studied, but few studies have reported saprobes of coffee. In China, Yunnan Province is the main region of coffee plantations and production. To investigate saprobic fungi of coffee plants, dead branches of Coffea with fungal fruiting bodies were collected in Baoshan City, Yunnan Province, China. Multi-gene phylogenetic analyses of SSU, ITS, LSU, RPB2, and TEF1-α sequence data indicated that our collections formed an independent branch within Brunneofusispora and sister to B. sinensis. The new species B. baoshanensis, characterized by uniloculate ascomata with an erumpent long neck, and inequilateral, ends acute, 1-septate, constricted at the septum ascospores with mucilaginous sheath, was identified based on morphology and multi-gene phylogeny. This is the first report of Brunneofusispora species isolated from Coffea in China. A complete description, micrographs, and a phylogenetic tree showing the placement of the new species are provided.
Epimedium daiguii (Berberidaceae), a new species from central China
Authors: ZHANG CHENG , LIU XIANG , NIE ZE-LONG , MENG YING , GUO BAO-LIN , LIU QUAN-RU
Published: January 2024

Epimedium daiguii C. Zhang, B.L. Guo & Q.R. Liu, a new species of the Epimedium, is found and described from Wuling Mountains, Hunan Province, China. It should be a member of Epimedium sect. Diphyllon ser. Brachycerae due to the distinct minor flower feature. This new species resembles E. elachyphyllum (E. parvifolium) in flower traits. The stout rhizomes, flowering stem with two opposite trifoliolate leaves and paniculate inflorescences of this new species distinguish from E. elachyphyllum with elongated rhizomes, flowering stem with a single leaflet, and simple inflorescences.
Manufacturing and Structural Analysis of a Composite Sandwich Panel Used for Aircraft Flooring
Authors: Kumar Anil , Supale Jayant P.
Published: January 2024

For better performance, lighter, stronger, and more durable materials are sought for the aeronautical industry. Composite Sandwich structures help in achieving almost all such requirements. Inserting a low density, lightweight, and thick core between two strong, rigid, and thin facesheets
can create a composite sandwich construction. It has been observed that there is a scarcity of research data on sandwich structures having Kevlar honeycomb as a core material. So a composite sandwich panel with Carbon fiber facesheets with a thickness of 0.4 mm and a Kevlar honeycomb core
with a cell size of 4.8 mm and a height of 10 mm has been manufactured. Then a number of tests have been performed on the different specimens obtained from the sandwich panel to identify its different properties. Also Acid Corrosion test has also performed on the panel to determine the acid
effects on it. From the analysis, it has been observed that the sandwich panel with Carbon fiber facesheets and Kevlar honeycomb core can be a suitable combination for aircraft floor panel.
An Analysis of the Efficient Use of Nanoparticles in Air Conditioners Based on Vapour Compression Refrigeration Systems
Authors: Hussain Hakimuddin A. , Langde Akash M.
Published: January 2024

The urgent need for energy-saving initiatives has shifted its focus to improve air conditioner efficiency. Room air conditioners are used by roughly half of India’s population, so their performance must be improved. Any improvement in the performance of the air conditioner will
result in significant energy savings. Nanoparticles in base fluid are used to improve the performance of Vapour Compression Refrigeration System i.e., VCRS-based air conditioners by taking advantage of increased thermal conductivity. This paper summarises the various approaches to using nanofluid
in air conditioners based on the Vapour Compression Refrigeration System (VCRS). It covers methods such as using nanoparticles as a secondary fluid for heat extraction, nanorefrigerant and nanolubricant which will aid researchers in exploring newer methods of improvement
Study of Solar Photovoltaic Array for Air Conditioning System
Authors: Bhatkar Vijay W. , Allampallewar Girish L. , Deshmukh Vivek N.
Published: January 2024

The vapor compression refrigeration (VCR) and air conditioning systems are widely used for cooling, refrigeration, air conditioning, heating purposes and consumes more than 33% of the world energy. Solar energy is available abundantly as renewable energy source in summer when requirement
of comfort is in peak demand. The electrical energy is replaced with solar energy by properly selecting solar panels, battery, inverter, charge controllers for storing fruits and vegetables in rural areas due to uncertain pattern of grid electricity. In the paper, solar power VCR system is
designed and simulated with Simulink to estimate the performance in terms of irradiance and temperature. It is found that with rise in irradiance, current and power outcome increases. The solar system is CO2 free with substantial saving of 9700 whereas conventional VCR system produces
5292 kg of CO2 during life time of solar PV system.
Thermal and Mechanical Design of Superheater for Process Industries
Authors: Bhatkar Vijay W. , Allampallewar Girish L. , Langade Sandip P. , Deshmukh Vivek N.
Published: January 2024

The superheater is an important boiler accessory which is widely used in power generation, sugar factories and process industries for ensuring good quality of steam for power generation. This increases the efficiency and life of the turbine blades for thermal power plant. In the research
work, pendant type convective superheater is designed for 20 Tonnes/hr for power generation in food processing industry with steam outlet pressure of 45 kg/cm2 and temperature of 450 °C. The superheater was designed considering thermal and mechanical aspects. The process of
thermal design involved calculation of overall heat transfer coefficient and surface area for heat transfer. Three-dimensional model of superheater using CATIA V5R20 was created and analysed. The process of mechanical design was used to calculate the working pressure and ensured safe design
of superheater.
Effect of Stroke Length (50 mm and 100 mm) on the Dry Reciprocating Wear Characteristics of Refined and Unrefined A390 Alloy
Authors: Suresh Kumar V. B. , Rajeev V. R. , Asok Kumar N.
Published: January 2024

The present work reports the influence of stroke lengths viz. 50 mm and 100 mm on the reciprocating wear characteristics of refined and unrefined hyper eutectic aluminium silicon alloy (A390). The refined A390 alloy was prepared through the electromagnetic stirring process along with
the addition of 0.1 wt.% Al–5Ti–B grain refiner. The wear tests were performed in an indigenously developed pin on reciprocating plate tribometer conforming to ASTM G 133-05 standard. The microstructure had shown the refinement of eutectic silicon and decrease in size of polyhedral
primary silicon particles due to the combined action of grain refiner addition and electromagnetic stirring. Refined and unrefined A390 alloys were heat treated under T6 condition. Hardness of the refined A390 alloy (107 BHN) was higher than that of unrefined A390 alloy (89 BHN). Reciprocating
wear tests were conducted at two stroke lengths with contact loads varied from 15 N to 60 N and the linear velocity from 0.2 m/s to 1.0 m/s for a constant sliding distance of 350 m. During the wear tests it was observed that as the velocity varied from 0.2 m/s to 0.4 m/s the wear loss was
found to decrease at both stroke lengths tested for refined and unrefined samples, further increase in velocity increases the wear rate. As the stroke length varied from 50 mm to 100 mm the wear loss was found to decrease for both refined and unrefined alloys. This reduction in wear loss with
increase in stroke length was due to the reduced reversals of load happening at larger stroke length (100 mm) also the frequency of reciprocation is high at 50 mm stroke length compared to that at 100 mm for the similar sliding conditions tested.
Effect of Stroke Length on the Abrasive Wear Characteristics of A-356 (0–10 wt%) SiCp Composite in Reciprocating Sliding Conditions
Authors: Sasi N. , Rajeev V. R. , Asok Kumar N.
Published: January 2024

In this study, abrasive wear behavior of A356/(0–10)wt.% SiCp composites are reported using an in house designed and developed pin-on-reciprocating plate abrasive wear and friction test rig confirming to ASTM G133-05 standards. A356 alloy and A356/10 wt.% SiCp
composite are prepared through stir casting method adopting standard foundry practices. The hardness of heat treated A356/10 wt.% SiCp composite is found to be 22.56% higher than A356 alloy. This study primarily focused on the effect of variation of stroke length from 65 mm to 100
mm on the abrasive wear characteristics of A356 alloy and it’s composite at different loads (5, 7.5, 10, and 12.5 N) by keeping a constant sliding velocity of 0.2 m/s slid through 25 m. The abrasive wear is found to be higher for the alloy than the composite. It is also revealed from
the experimental investigation that as the stroke length is reduced from 100 mm to 65 mm, the abrasive wear loss of A356 alloy and its composites are found to increase. The reason for increase in wear is attributed to high frequency of oscillation and less energy dissipation per cycle at lower
stroke length (65 mm) compared to that at higher stroke length (100 mm). Coefficient of friction (CoF) of tribo pairs tested is found to increase with load at the two different stroke lengths studied.