bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH PROFITABILITAS DAN STRUKTUR MODAL TERHADAP NILAI PERUSAHAAN PT. JABABEKA, Tbk
Authors: Rakhmat Adriana Syariefur
Published: January 2019

Firmâ€™s value is investor perception of the company, which is often associated with stock prices, higher stock prices could increase the firmâ€™s value. Firmâ€™s value is proxied by Price Book Value (PBV) which is a market ratio used to measure the performance of the stock prices to itâ€™s book value. The present study is aimed at finding out the influence of profitability proxied by Return On EquityÂ  (ROE) and capital structurÂ  proxied by Debt to Equity Ratio (DER) on firmâ€™s value.The population of the study are quarterly financial statements on PT. Jababeka, Tbk that were listed at Indonesian Stock Exchange in year period of 2011 â€“ 2015. Testing the hypothesis in this study using a software toll SPSS (Statistical Product and Service Solution) versionÂ  22.The result of this study showed that : (1)Â  profitability positively and significantly influence firmâ€™s value; (2) capital structure positively and significantly influence firmâ€™s value; (3) profitability and capital structure significantly influence firmâ€™s value.Â Keywords:Price Book Value, Return On Equity, and Debt to Equity Ratio
PENGARUH KUALITAS PELAYANAN DAN KEBIJAKAN HARGA TERHADAP KEPUASAAN KONSUMEN PT. HLS YAMAHA MUSIC DI PEJATEN VILLAGE MALL JAKARTA SELATAN
Authors: Muslikah Ani , Gunawan Yoyo Indah
Published: January 2019

Kualitas Pelayanan dan Kebijakan Harga merupakan dua hal dar beberapa faktor yang diduga relatif besar dalam mempengaruhi kepuasan konsumen PT HLS Yamaha Music Pejaten Village Mall Jakarta Selatan. Untuk membuktikan pengaruh keduanya maka dilakukan penelitian ini dengan tujuan untuk mengetahui pengaruh kualtas pengaruh dan kebijakan harga terhadap kepuasan konsumen PT HLS Yamaha Music Pejaten Village Mall Jakarta Selatan.Penelitian dilakukan di PT HLS Yamaha Music Pejaten Village Mall Jakarta Selatan dengan mengambil 91 konsumen sebagai sampel penelitian yang dihitung menggunakan rumus slovin dari total populasi 926 konsumen pada margin eror 10% didapat sampel 91. Pengambilan data dilakukan dengan instrumen kuisioner tertutup dengan lima skala penelitian dari sangat tidak setuju sampai dengan sangat setuju. Penelitian dilakukan secara kuantitatif yaitu dengan mendeskripsikan data penelitian dan melakukan analisis. Analisis regresi sederhana ganda digunakan sebagai alat analisis sedangkan pengujian hipotesis dilakukan dengan uji-t dan uji-F.Penelitian menghasilkan model persamaan regresi Å¶ = 8.840 + 0.308X1 â€“ 0,118X2 dengan temuan bahwa ada pengaruh kualitas pelayanan dan kebijakan harga terhadapa kepuasan konsumen pada PT. HLS Yamaha Music Pejaten Village Mall Jakarta Selatan dengan memberikan konribusi sebesar 25%. Terdapat pengaruh Kualitas Pelayanan terhadap kepuasan konsumen dan Tidak terdapat pengaruh Kebijakan Harga terhadap kepuasan konsumen.Berdasarkan hasil temuan tersebut maka untuk meningkatkan kepusan konsumen disarankan agar dilakukan upaya memperbaiki kualitas pelayanan dan kebijakan harga terutama meningkatkan kualitas pelayanan.Â Kata kunci:Kualitas Pelayanan, Kebijakan Harga, Kepuasan Konsumen
Perbedaan Ekspresi Foxp3+ dan Cd8+ Tumor Infiltrating Lymphocytes Karsinoma Payudara pada Berbagai Stadium T
Authors: Indiralia Anisia , Rahniayu Alphania , Mustokoweni Sjahjenny
Published: January 2019

Background: Breast carcinoma, the most common malignancy in women, are often accompanied by tumor infiltrating lymphocytes (TIL) which has controversial clinical relevance. TIL is thought to reflect the host’s immune response to malignant tumors. FOXP3, specific biomarker of Treg, is an important transcription factors that develops and functions in the maintenance of self tolerance, including inhibition of CD8+ cytotoxic T cell function. Aim: To analyze the differences and the correlation between FOXP3+ and CD8+ TIL in breast carcinoma with different T staging. Methods: An analytical observational research, performed on 44 paraffin block of breast carcinoma of various stages T (AJCC 7th ed) in anatomical pathology installation of RSUD Dr. Soetomo, used FOXP3+ and CD8+ antibodies. The immunoexpression are evaluated on stromal area, then analyzed statistically, period January 1, 2014 – December 31, 2016. Result: Showed significant differences in FOXP3+ expression between T1-T4, T2-T3, T2-T4, T3-T4. There were significant differences in CD8+ expression between T2-T3, T2-T4. There is a correlation between the expression of FOXP3+ and CD8+ in T1 and all T (p < 0.05). Conclusion: There was significant difference in FOXP3+ and CD8+ TIL of breast carcinoma with increasing T stage. There was correlation between FOXP3+ and CD8+ TIL expression of breast carcinoma at all T and T1 stage. ABSTRAKPendahuluan: Karsinoma payudara adalah keganasan terbanyak wanita dan sering didapatkan adanya tumor infiltrating lymphocytes (TIL) dengan relevansi klinis yang masih kontroversial. TIL sering dianggap mencerminkan respon imun inang terhadap tumor ganas. FOXP3, biomarker spesifik Treg, merupakan faktor transkripsi yang penting dalam perkembangan dan berfungsi dalam pemeliharaan self tolerance, termasuk penghambatan fungsi sel T sitotoksik CD8+. Metode: Penelitian observasional analitik terhadap 44 sampel blok parafin karsinoma payudara berbagai stadium T (AJCC edisi ketujuh) di instalasi Patologi Anatomi RSUD Dr. Soetomo Surabaya menggunakan antibodi FOXP3 dan CD8, dihitung pada area stroma tumor, kemudian dilakukan uji statistik periode 1 Januari 2014 – 31 Desember 2016. Hasil: Terdapat perbedaan bermakna ekspresi FOXP3+ antara T1 dan T4, T2 dan T3, T2 dan T4, T3 dan T4. Terdapat perbedaan bermakna ekspresi CD8+ antara T2 dan T3, T2 dan T4. Terdapat korelasi antara tingginya ekspresi FOXP3+ dengan tinginya ekspresi CD8+ pada T1 dan semua T (p < 0,05). Kesimpulan: Terdapat perbedaan bermakna ekspresi FOXP3+ dan CD8+ TIL karsinoma payudara dengan meningkatnya stadium T. Terdapat korelasi antara ekspresi FOXP3+ dan CD8+ TIL karsinoma payudara pada semua stadium T dan T1.
Effects of Curcumin on Vascular Endothelial Growth Factor Expression on Rattus norvegicus Cervical Cancer Xenograft Model
Authors: Muninggar Laili , Widjiati Widjiati , Yuliati Indra , Askandar Brahmana , Hartono Poedjo
Published: January 2019

Objective: To analyze the effect of curcumin in VEGF expression on Rattus norvegicus cervical cancer cell xenograft model.Methods: An experimental study with randomized post test only control group design. The subjects were Rattus norvegicus (Sprague Dawley), inoculated with He-la cervical cancer cells from American Type Culture Collection (ATCC) processed in stem cell laboratory Institute of Tropical Disease (ITD) Airlangga University. 5x106 of He-La cells were injected subcutaneously in dorsal flank area of Rattus norvegicus. After 30 days of observation we performed histopathological examination of xenograft tissue and randomized into 2 groups which were given curcumin orally 1000 mg/kg (curcumin group) vs. no therapy (control group). After another 30 days the xenograft tissue was dissected and underwent immunochemistry examination for VEGF expression.Results: 32 samples of Rattus norvegicus were divided into 2 groups, In curcumin group the VEGF median expression was 2,2 (0,3-7,6) and in control group the VEGF median expression was 6,6 (1,2-12). There was a statistically significant difference with p value =0,009 with Mann Whitney test (p<0,05).Conclusion: VEGF expression in Rattus norvegicus xenograft model of cervical cancer was suppressed by giving Curcumin 1000 mg/kgBB orally.
Penerapan Teknik Data Mining dengan Metode Support Vector Machine (SVM) untuk Memprediksi Siswa yang Berpeluang Drop Out (Studi Kasus di SMKN 1 Sutera)
Authors: Fiska Ryci Rahmatil
Published: January 2019

Drop out adalah suatu keadaan di mana siswa diberhentikan dari sekolah karena beberapa alasan yang mengharuskan siswa untuk di drop out . faktor drop out seperti absen yang telah melebihi batas maksimal, nilai yang kurang dari batas bawah yang telah ditentukan pihak sekolah dan prilaku siswa yang sudah melanggar nilai attitude yang telah diterapkan oleh pihak sekolah. Dalam penelitian ini penulis ingin memprediksi siswa yang berpeluang drop out dengan menggunakan metode SVM dan diharapkan mampu memprediksi masalah drop out apakah siswa akan lanjut ke semester selanjutnya atau di drop out karena beberapa alasan. Dan hasil yang disimpulkan adalah metode SVM mampu memprediksi siswa yang berpeluang drop out.Kata kunci : Support Vector Machine, Kernel Trick, Drop Out.
Penerapan Algoritma Nearest Neighbor Retrieval Untuk Mendiagnosa Penyakit Hepatitis
Authors: Mahmud Samsudin sadek
Published: January 2019

Hepatitis merupakan penyakit peradangan hati karena berbagai sebab. Penyebab tersebut adalah beberapa jenis virus yang menyerang dan menyebabkan peradangan dan kerusakan pada sel-sel dan fungsi organ hati. Untuk mengetahui jenis hepatitis yang diderita pasien sistem pakarÂ  telah dibangun menggunakan analisis pendekatan Cased-based Reasoning(CBR) dalam membangun sistem ini menggunakan pemodelan UML, metode perhitungan menggunakan kemiripan kasus lama dengan kasus baru atau Similirity. Untuk pengujian kelayakan software menggunakan Alfa Testing, dengan indicator mudah digunakan, informasi cepat, biaya murah dimana dalam pengujian menggunakan 10 sample user dengan hasil software diagnosa hepatitis layak dan bisa digunakan.
Perancangan Aplikasi Berbasis Client Server dalam Mengupload File-File Ujian pada Laboratorium Komputer STMIk Amik Riau
Authors: Muzawi Rometdo , - Rahmaddeni , - Agustin
Published: January 2019

Client-serverÂ  merupakan sebuah paradigma dalam teknologi informasi yang merujuk kepada cara untuk mendistribusikan aplikasi ke dalam dua pihak yaitu pihak client dan pihak server. Dalam model clien-server, sebuah aplikasi dibagi menjadi dua bagian yang terpisah, tapi masih merupakan sebuah kesatuan yakni komponen client dan komponen server. Berdasarkan teknik client-server dirancanglah sebuah aplikasi yang dapat berinterasi dengan pengguna dalam proses penguplodan file-file ujian yang diberikan oleh dosen baik untuk program studi Teknik Informatika maupun program studi Manajemen Informatika. Aplikasi yang dirancang menggunakan pemrograman PHP dan database MySQL pada server. Hasil yang diberikan berupa aplikasi dengan teknik client-server yang dapat digunakan oleh mahasiswa dan pihak laboran. yang mencakup keperluan dalam hal penguploadan file-file ujian mahasiswa. Simpulan yang diberikan dalam penelitian ini secara umum dapat mengefesiensi waktu dari pihak mahasiswa dalam proses penguplodan file ujian dan pihak laboran dalam proses pembuatan laporan.
DIAGNOSIS PENYAKIT RADANG SENDI DENGAN METODE CERTAINTY FACTOR
Authors: Arlis Syafri
Published: January 2019

Proses penuaan akan menyebabkan perubahan anatomis, fisiologis dan biokimia pada tubuh, sehingga akan mempengaruhi fungsi dan kemampuan tubuh secara keseluruhan. untuk mendiagnosis penyakit radang sendi memerlukan sistem yang mampu membantu untuk mendiagnosis penyakit radang sendi (Arthritis) yang didasarkan pada basis pengetahuan yang dinamis. Basis pengetahuan ini berisi pengetahuan yang didapatkan dari berbagai sumber diantaranya dari pengalaman pakar dalam bidangnya dan juga buku yang berhubungan dengan diagnosis penyakit radang sendi yang kemudian dikumpulkan ke dalam basis data yang diperlukan untuk pengambilan keputusan. Dalam sistem ini akan digunakan metode certainty factor dengan mesin inferensi forward chaining. Dengan pembuatan sistem pakar ini diharapkan akan dapat bermanfaat bagi masyarakat banyak dan dapat mengetahui dengan jelas tentang penyakit radang sendi dari gejala dan Â solusinya.Â Kata Kunci : radang sendi, arthritis, certainty factor
Sistem Informasi E-Bussiness Penyediaan Jasa Cleaning Service Indoor (Study kasus : PT. Inti Lestari Padang
Authors: Kurnia Dona Kurnia
Published: January 2019

Penggunaan perusahaan penyedia jasa kebersihan pada perusahaan atau instansi-instansi semakin marak saat ini. Ketersediaan jasa kebersihan tersebut menawarkan layanan diantaranya jasa kebersihan dalam ruangan, luar ruangan serta dalam dan luar ruangan. Kita mampu memilih sendiri karyawan yang akan direkrut dengan kelebihan masing-masing. Â Tulisan ini bertujuan untuk memberikan informasi seputar penyediaan cleaning service indoordengan study kasus pada PT. Srikandi Inti Lestari Padang yang berbasis online agar memudahkan konsumen mendapatkan informasi jasa dan melakukan pemesanan jasa tanpa harus langsung mendatangi kantor PT. Srikandi Inti Lestari Padang. Sistem ini dirancang dengan menggunakan bahasa pemrograman PHP dan database MySQL. Metode penelitian adalah Observasi, Wawancara, Studi Pustaka. Parameter yang diteliti adalah : Analisis Sistem (ASI lama), Rancangan global (Use Case Diagram, Activity Diagram, Sequence Diagram, dan Class Diagram), Rancangan rinci (Desain Input, Desain Output, Desain File, serta rancangan program). Dari penelitian ini dapat disimpulkan bahwa media website dapat digunakan untuk proses promosi dan sebagai sarana pemesanan jasa kebersihan dalam ruangan pada PT. Srikandi Inti Lestari Padang.Â Kata Kunci :Sistem Informasi,E-Bussiness, Indoor, Database
Strategi Manajemen Komunikasi Mempertahankan Reputasi
Authors: Widiasanty Gita
Published: January 2019

Hiburan merupakan hal yang dimaksudkan untuk menghibur atau menarik orang, salah satu bentuk hiburan adalah musik. Bermain musik dapat dilakukan secara bersama membentuk sebuah kelompok musik yang lebih dikenal dengan band. Di Indonesia banyak band pendatang baru, walaupun demikian terdapat band yang sudah berdiri lama namun masih produktif mengeluarkan album hingga sekarang. Kahitna adalah grup musik asal Bandung yang dibentuk 24 Juni 1986, merupakan salah satu band di Indonesia yang mempunyai kekuatan merata di semua lini ditandai dengan aktivitas para personilnya. Walau lintasan trend dan jaman telah berlalu namun Kahitna masih berdiri tegak dan tetap dengan notasi indah penuh romantisme tingkat tinggi, sebuah kekuatan yang selalu hadir dalam lagu-lagu Kahitna, senjata itulah yang membuat Kahitna bertahan sampai saat ini. Alasan pemilihan topik ini karena Kahitna dapat bertahan eksistensinya sampai saat ini, walaupun terdapat band-band di Indonesia yang usia terbentuknya sama dengan Kahitna yaitu Java Jive, Kla Project, dan Dewa19 yang sama-sama memiliki karya-karya yang baik, reputasi yang baik dan memiliki usia keemasan yang lama, namun berdasarkan fakta, Kahitna adalah band yang masih bertahan hingga saat ini dengan mengeluarkan album-album dan mengadakan show secara kontinyu. Bertolak dari permasalahan tentang pentingnya strategi komunikasi dalam mempertahankan reputasi Kahitna, maka penelitian ini dilakukan untuk mengetahui lebih dalam cara penggunaan strategi manajemen komunikasi dalam manajemen artis Kahitna sehingga popularitasnya konsisten sampai sekarang.
Analisis Kualitas Air yang Tercemar Merkuri (Hg) di Perairan Teluk Kao Halmahera Utara
Authors: Husen Azis
Published: January 2019

AbstrakPenelitian ini menganalisis dan menentukan tingkat pencemaran merkuri (Hg) di perairan Teluk Kao Halmahera Utara. Metode yang digunakan adalah metode survei observasi wawancara dan pengambilan sampel air dengan cara purposive sampiling sedangkan untuk analisis air dan sedimen mengunakan alat spektrofotometer penyerap atom (atomic absorption spectrophotometer, AAS).  Analisis kualitas air sungai, air laut di perairan Teluk Kao Halmahera Utara untuk pagi dan sore dengan nilai sebesar 0,004 mg/L - 0,0038 mg/L.  Sedangkan kandungan merkuri (Hg) untuk sedimen pagi dan sore dengan nilai 0,0032,  mg/L - 0,0076 mg/L.  Berdasarkan dari hasil tersebut bahwah mutu air sungai Kobok dan Taolas di perairan Teluk Kao Halmahera Utara sudah tidak bisa dikonsumsi sesuai Peraturan Pemerintah Pengelolaan air minum secara konvensional (kelas 1), 0,001 ppm, (kelas 2 dan 3), 0,002 ppm dan (kelas 4). 0,005 ppm dengan demikian mutu air sungai Teluk Kao sudah tidak aman untuk di konsumsi bagi masyarakat Teluk Kao.  Sedangkan untuk sedimen sungai Kobok dan Taolas Teluk Kao sudah tidak lagi memenuhi Standar Bahan Baku Mutu sesuai Peraturan Pemerintah No. 82 Tahun 200 kelas I. 0,001 mg/L kelas II. 0,002 mg/L kelas III. 0,002 mg/L kelas IV 0,005 mg/L. Kata kunci: Pencemaran; merkuri (Hg);air sungai; air laut; sedimen AbstractThe research analyzed and determined the level of mercury (Hg) pollution in Kao Gulf waters of North Halmahera. Method used was survey, observation, and interview. Water sampling was conducted with purposive sampling. Water and sediment analysis was conducted using atomic absorption spectrophotometer (AAS). Analysis of river water and sea water quality in Kao Gulf waters of North Halmahera was conducted in the morning and afternoon with value of 0.004 mg/L – 0.0038 mg/L. Whereas, mercury (Hg) content for sediment in the morning and afternoon was 0.0032,  mg/L – 0.0076 mg/L. Based on the result, the water quality of Kobok and Taolas River in Kao Gulf waters of North Halmahera cannot be consumed because based on the Government Regulation on conventional drinking water management the water quality value is 0.001 ppm (class 1), 0.002 ppm (class 2 and 3), and 0.005 ppm (class 4); therefore, the water quality in Kao Gulf river is not safe to be consumed by the community in Kao Gulf. Regarding sediment of Kobok river and Taolas of Kao Gulf, it was no longer met the Quality Standard according to the Government Regulation No. 82/2001 which is:  Class I of 0.001 mg/L, Class II of 0.002 mg/L, Class III of 0.002 mg/L and Class IV of 0.005 mg/L. Keywords: Pollution; mercury (Hg); river water; sea water; sediment
Dekomposisi Serasah Avecennia lanata pada Berbagai Tingkat Kedalaman Tanah
Authors: Saibi Ningsi , Tolangara A.R.
Published: January 2019

AbstrakSerasah mangrove berperan penting dalam kesuburan perairan pesisir. Serasah mangrove yang terdekomposisi akan menghasilkan unsur hara yang diserap oleh tanaman dan digunakan oleh jasad renik di lantai hutan dan sebagian lagi akan terlarut dan terbawa air surut ke perairan sekitarnya. Penelitian dilakukan dengan cara menghitung penyusutan bobot serasah awal yang terdekomposisi kemudian membandingkan bobot serasah yang terdekomposisi tiap bulan. Penelitian bertujuan untuk mengetahui pengaruh tingkat kedalaman tanah yang dapat mempercepat proses dekomposisi serasah. Hasil penelitian menunjukkan bahwa kedalaman tanah berpengaruh terhadap laju dekomposisi serasah jenis Avecennia lanata,  tiap kedalaman tanah memiliki jenis dan jumlah mikroorganisme yang berbeda-beda, kondisi ini akan dapat berpengaruh terhadp laju dekomposisi serasah dan tingkat kedalaman 10 cm yang paling berpengaruh terhadap laju dekomposisi serasah Avecennia lanata yaitu yaitu sebesar 0,29-0,39 gram/hari. Kata kunci: dekomposisi serasah, Avecennia lanata, Tingkat kedalaman tanah AbstractMangrove litters play important role in coastal water fertility. The decomposed mangrove litters will produce nutrient absorbed by plants and some of them will be used by microorganisms in wood floor and the other will be dissolved and carried by the low tide to the surrounding waters. The research was conducted by calculating the depreciation of the initial weight of the decomposed litters and comparing it to the decomposed litter weight every month. The research aimed to find out the influence of soil depth that could accelerate litters decomposition process. The research result indicated that soil depth influenced the decomposition rate of Avecennia lanata litters. Each soil depth had different type and number of microorganisms. The condition would influence the decomposition rate of the litters. Soil depth of 10 cm was the most influential on the decomposition rate of Avecennia lanata litters, which was 0.29-0.39 gram/day. Keywords: litters decomposition, Avecennia lanata, Soil depth
Hama pada Cabai Merah
Authors: Cahyono Didi Budi , Ahmad Hasna , Tolangara A. R.
Published: January 2019

AbstrakHama merupakan hewan yang merusak tanaman dan umumnya merugikan para petani dari segi ekonomi, maka manusia selalu akan memperhatikannya, guna meningkatkan hasil pertanian, jika tidak hasil panennya akan menurun. Adapun tujuan penelitian inim untuk mengetahui keanekaragaman jenis hama yang menyerang tanaman cabai merah. Metode penelitian ini bersifat deskriptif kualitatif, dengan menggunakan perhitungan indeks keanekaragaman jenis. Hasil penelitian menunjukkan bahwa Jenis hama yang ditemukan pada tanaman cabe merah terdiri dari jenis  Locusta migratoria manilensis, Gryllus mitratus, Grylloptalpa africana, Lycosa sp, Spodoptera litura L., Mycus percicae, Planococus citri, Aulocophora sp,  Epilachna argus. Populasi hama tertinggi adalah ulat grayak (Spodoptera litura L.) dan jenis yang memiliki populasi terendah yaitu orong-orong (Grylloptalpa africana). Keankaregaman jenis hama pada tanaman cabe merah memiliki nilai keragaman sebesar H’ = 1,825, maka dikategorikan keanekaragaman jenis sedang.Kata kunci: Jenis hama, Tanaman Cabe, Keanekaragaman jenis AbstractPest is a destructive animal for plants and is generally harming the farmers in terms of economic aspect. Thus, people always put their attention to it in order to increase the produce otherwise the harvest will be decreased. The research aimed to find out the diversity of pest type attacking chili pepper crop. The research method was qualitative descriptive using the calculation of diversity index. The research result indicates that the types of pest found in chili pepper crop were: Locusta migratoria manilensis, Gryllus mitratus, Grylloptalpa africana, Lycosa sp, Spodoptera litura L., Mycus percicae, Planococus citri, Aulocophora sp, and Epilachna argus. The highest population was taro caterpillar (Spodoptera litura L.) and the lowest was mole cricket (Grylloptalpa Africana). The diversity of pest in chili pepper has diversity value of H’ = 1.825 and it categorized as medium diversity.Keywords: Type of pest, Chili pepper, Type diversity
Pengembangan Protokol Isolasi DNA Genom Tanaman Durian Dengan Menggunakan Modifikasi Bufer CTAB
Authors: Sundari Sundari
Published: January 2019

AbstrakProtokol dan metode sederhana, efisien untuk isolasi  DNA genom tanaman durian   yang banyak mengandung phenol dan residu polisakarida telah dihasilkan. Pada penelitian ini, digunakan  protokol isolasi DNA tumbuhan  dengan metode CTAB yang dimodifikasi sebagai protokol yang  efisien untuk membuang polisakarida, phenol  dan  lendir yang sangat melimpah pada tanaman durian. Obyek penelitian ini  terdiri dari protocol CTAB yang dimodifikasi  tahap inkubasi dan presipitasi  pemurnian DNA genom dari phenol dan polisakarida. Perbandingan 2  protokol  isolasi  DNA durian dengan CTAB standard an CTAB modifikasi  menunjukkan bahwa metode  CTAB modifikasi menghasilkan  whole genom durian cukup murni rata rata 1,99 dan berhasil diamplifikasi  dengan PCR-RAPD.Kata kunci:  isolasi, DNA, polisakarida, CTAB, modifikasi, . AbstractThe simple and efficient  method for genomic DNA isolation protochol from durian , its woody fruit crops containing high polysaccharide levels has been described here. In the present study, using modified CTAB for plant DNA isolation protocols were studied for removing the highly concentrated polysaccharides from genomic DNA of woody fruit crops.This method involves the modified CTAB   at the incubate  and precipitate procedure employing DNA purification  step to remove polysaccharides and phenol residu.  Compared with the two  studied DNA  isolation protocols of  durian using standart CTAB and modified CTAB  the everage yield  high quality DNA whole genom is 1,99 purity and DNA was suitable for PCR and RAPD analyses.Keyword: isolation, DNA,  polysaccharides,  phenol residu, CTAB
Sampah Rumah Tangga di Ternate
Authors: Bahtiar Bahtiar , Ahmad Zulkifli , Pobi Wiyana
Published: January 2019

Abstrak Jumlah penduduk Kota Ternate 212.997 jiwa, luas wilayah 111,39 km2 dengan kepadatan 1.865,42 jiwa/ km2. Apabila kita menggunaan pendekatan paradigma “sampah sebagai barang berguna” maka jumlah penduduk sebanyak itu menghasilkan volume sampah yang berpotensi untuk dimanfaatkan dan diolah kembali. Terkait kepentingan pengelolaan dan pemanfaatan sampah di Kota Ternate ke depan, maka kedudukan sampah merupakan sebuah potensi. Deskripsi potensi sampah harus diawali dengan pengenalan komposisi dan timbulan sampah yang ada, terutama sampah rumah tangga. Gambaran komposisi akan memberikan informasi tentang komponen yang terdapat dalam buangan padat beserta distribusinya. Timbulan sampah memberikan informasi banyaknya sampah rumah tangga yang dihasilkan. Data timbulan sampah juga diperlukan untuk desain sistem pengelolaan persampahan, seleksi jenis peralatan untuk transportasi sampah dan desain tempat pembuangan sampah. Kata Kunci:, komposisi sampah, rumah tangga, Kota Ternate  Abstract The population of Ternate City is 212,997 people, the area of 111.39 km2 with the density of 1,865.42 people/km2. If we use the paradigm approach of "waste as a useful item" then the amount of population as much as it produces the volume of waste that has the potential to be utilized and reprocessed. Related to the management and utilization of waste in Ternate City in the future, the position of waste is a potential. Description of potential waste should be started with the introduction of composition and waste generation, especially household waste. The composition description will provide information on the components contained in solid waste and its distribution. Waste generation provides information on the amount of household waste generated. Waste generation data is also required for the design of waste management systems, the selection of equipment types for waste transport and the design of landfills. Keywords: composition of waste, household, Ternate city
THE EFFECTIVENESS OF MATHEMATICAL LEARNING BASED ON PROBLEM SOLVING REVIEWED FROM STUDENTS’S MOTIVATION AND LEARNING ACHIEVEMENT
Authors: Saparwadi Lalu
Published: January 2019

This study aims to describe whether there are differences in learning mathematics-based problem-solving in terms of results and student motivation of mathematics. This type of research is a quasi-experimental research and the design carried out on this study is a pretest-postest nonequivalent group design. In this research, the observation was done twice, before and after treatment. Observations made earlier are called pre-test and later observations are called post-test. The result of the calculation of the implementation of mathematics learning with the problem-solving based approach to student achievement is significant (p = 0,000 <0.05). It showed a Fcount of 1.002 <Ftabel of 1.76 with a significance level of 5%. Thus H0 is accepted and Ha is rejected, meaning there is a significant difference in mathematics learning achievement between problem-solving approach and conventional. The result of the calculation of the implementation of mathematics learning with the problem-solving-based approach to student's learning motivation is significant (p-count = 0.03 <0.05) or refer to Fcount of 1.07 <Ftable of 1.76 with a significance level of 5%. So that Ho accepted, it means there are differences in student learning motivation that is taught between using problem-solving based learning and conventional learning. Learning with problem-solving approaches will be effective if the teacher as an educator prepares the problems according to the context. From the results of this study, the researchers recommend being used as a reference for similar research with different subject materials. This research can be developed by adding other attribute variables such as student self-confidence, verbal ability, motivation, nor critical thinking ability.
VIBRATION SENSOR BASED ON FLAT KOIL FOR EARTHQUAKE EARLY DETECTION IN LOMBOK NUSA TENGGARA BARAT REGION
Authors: Islahudin Islahudin , Ramdhan M. Firman
Published: January 2019

In this research has been developed the application of flat coil as vibration sensor for early detection of earthquake. The flat coil is a very thin wire winding and acts as an inductor. This flat coil along with the capacitor constructs an oscillator which generates frequencies depending on the value of inductance and capacitance. This oscillator is called the LC oscillator. The flat coil inductance depends on the distance of the metal object in front of the flat coil. If the inductance changes, the frequency will change as well. Frequency can be converted into voltage form to represent distance. This effect is then applied to low frequencies using a pendulum on the sensor housing. The sensor system created can measure low-frequency vibrations in the range 0.26 - 1.0 Hz. Based on the research, the vibration sensor that has been made can measure one of the low frequency vibrations of 0.468 Hz at the frequency of 0.46 Hz vibration source
IDENTIFIKASI STRUKTUR SENYAWA ANTIJAMUR DARI RUMPUT LAUT
Authors: Rahmawati Rahmawati
Published: January 2019

Screening of plants antifungal compounds from Algae has been resulted. Screening was preceded by extraction of its fresh substance with benzene, methanol, and chloroform solvents and followed examination towards fungi Fusarium oxysforum, Sclerotium rolfsii, Aspergillus flavus, and Pythium spp. The antifungal effects were tested by well methode in potato dextrosa agar (PDA) medium. Analysis compound of benzene extract with preparative TLC methode (n-hexene : ethyl acetate : methanol = 7 : 2 : 1) obtained 5 compounds. Antifungal activity test of the fractions was done by the disk diffution methode with PDA medium. Identification of active compounds with spectroscophy method (IR and NMR) indicated the benzene extract analogue with fungicide Metalaxyl with the benzene ring and substituens of ester, alkyl, and amide. Identification of fractions showed that the compounds analogue with fungicides belong to carboxamide with the main substituen of benzene ring and ester/aldehids formed, alkyl, and  amide.
Pengaruh Context-Rich Problems Berbentuk Multimedia Interaktif terhadap Keterampilan Proses Sains, Sikap Ilmiah, dan Pemahaman Konsep
Authors: Khery Yusran , Khaeruman Khaeruman
Published: January 2019

The purpose of this study was to evaluate the effect of context-rich problems in the form of interactive multimedia on chemical students’ science process skills, scientific attitudes, and conceptual understanding in practical activities. This research is the quasi-experimental study with post test only control group design. The research sample consisted of 142 students divided into 3 groups. The 1st experimental group was treated using a context-rich problem in the form of interactive multimedia before practical activities, the 2nd experimental group used conventional rich problems, and control groups without context-rich problems. Data were collected by the science process skills observation sheets and portfolio, scientific attitude observation sheets, and conceptual understanding tests. Data were analyzed by inferential statistical methods using SPSS 15 software for windows. The results showed that the context-rich problems in the form of interactive multimedia had an effect on students' science process skills, scientific attitudes, and conceptual understanding.
Pengaruh Pembelajarn Kooperatif Student Teams Achivement Division (STAD) Terhadap Keteramilan Berpikir Kritis Siswa
Authors: Samsuri Taufik , Firdaus Laras
Published: January 2019

Kualitas pendidikan merupakan salah satu fakor atau indikator yang menunjukkan kualitas suatu bangsa. Oleh karena itu, kualitasnya harus terus ditingkatkan. Peninkatan kualitas pendidikan tersebut sejalan dan seirama dengan tuntutan kemajuan zaman yang menekankan pada pengetahuan dan keterampilan, seperti pentingnya dibelajarkan tentang keterampila berpikir tingkat tinggi, salah satunya adala keterampilan berpikir kritis. Keterampilan berpikir kritis merupakan keterampilan hidup dan modal dasar yang harus dimiliki siswa untuk memperoleh dan mengembangkan pengetahuan, dalam hal ini dipaami bahwa, apabila siswa memeiliki keterampilan berpikir kritis, maka siswa akan memiliki keterampilan atau pengetahuan untuk menyelesaikan masalah. membelajarkan keterampilan berpikir kritis kepada siswa dapat dilakukan dengan berbagai metode atau model pembelajaran, salah satunya adalah dengan model pembelajaran kooperatif STAD. Melalui model pembelajaran kooperatif STAD, siswa tidak hanya diberdayakan untuk memiliki keterampilan berpikir kritis, tetapi juga keterampilan sosial, karena karakteristik pembelajaran kooperatif adalah interaksi sosial antar siswa. Tujuan penelitian ini adalah untuk mendeskripsikan ppengaruh pembelajaran kooperatif STAD terhadap keteramppilan berpikir kritis siswa. Subjek penelitian ini adalah siswa kelas VII Madrasah Tsanawiyah NW Pringgabaya tahun pelajaran 2016/2017 Rancangan penelitian yang digunakan dalam penelitian ini adalah posttest control group desaign, dan sampel penelitian diambil menggunakan teknik sampel acak (random sampling). Berdasarkan hasil analisis menggunakan uji t dengan bantuan SPSS 16 for windows, diperoleh nilai uji t sebesar 5.06, dan nilai probabilitasnya sebesar 0.000, sehingga berdasarkan hasil analisis ini dinyatakan bahwa pembelajaran kooperatif STAD berpengaruh terhadap keterampilan berpikir kritis siswa kelas VII Madrasah Tsanawiyah NW Pringgabaya tahun pelajaran 2017/2018.
Pengaruh Metode Pembelejaran Diskusi Buzzgroup terhadap Keaktifan dan Prestasi Belajar Siswa
Authors: Apriyanti Nurvilia , Herayanti Lovy , Habibi Habibi
Published: January 2019

This study was conducted to determine the effect of buzz group discussion learning methods on the activeness and learning achievement of physics in class VIII of SMPN 4 Praya Barat Daya 2015/2016 Academic Year. The type of research used in this study is a kind of quasi-experimental research. The population in this study were all eighth-grade students totaling 38 people consisting of class VIII A totaling 20 people as the experimental class and class VIII B totaling 18 people as the control class with the sampling technique used was a saturated sampling technique. The instruments used are valid observation and test sheets both in content, construct, and empirical with a value of 3.34; 3.40; and 3.23, and reliable with the value of αCronbach = 0.608. The results of this study were also able to influence the achievement of learning physics. Based on statistical calculations using the ttest test, the value of tcount = 23.00 is greater than t table = 2.02 (t count = 23.00> t table = 2.02). Thus, it can be concluded that there is the influence of buzz group discussion learning methods on the activeness and learning achievement of physics in class VIII Praya Barat Daya SMP 4 2015/2016 Academic Year.
APPLICATION OF COMPUTER SIMULATION TO CONSTRUCTION OF INCREMENTAL LAUNCHING BRIDGES
Authors: Marzouk Mohamed , El-Dein Hisham Zein , El-Said Moheeb
Published: January 2019

Construction of bridges is associated with uncertainties that rise due to unavailability of resources, equipment breakdown and/or working environment. Bridge construction techniques can be grouped into six main categories: 1) cast‐in‐situ on false work, 2) cantilever carriage, 3) stepping formwork, 4) launching girder, 5) pre‐cast balanced cantilever, and 6) incremental launching. The latter technique is characterised by minimising the use of falsework. Further, the fabrication and casting of bridge segments are executed at a stationary location, named casting yard (which includes several facilities), deck form, concrete mixing unit, and pumping system. This paper presents a special purpose simulation model to capture the uncertainty associated with bridge construction. The model accounts for the interaction between the different involved resources in construction of bridges using incremental launching technique. The paper describes two methods (single form and multiple forms) of execution used for the segments fabrication. The proposed simulation model utilises STROBOSCOPE as a simulation engine and is coded by Visual Basic 6.0. An actual case study is presented to illustrate the capabilities of the developed model and validate its performance.
MATHEMATICAL‐NEURAL MODEL FOR ASSESSING PRODUCTIVITY OF EARTHMOVING MACHINERY
Authors: Schabowicz Krzysztof , Hola Bozena
Published: January 2019

Many construction processes are carried out by machines working together and forming technological systems, eg earthmoving machinery made up of excavators and haulers (trucks). Productivity (W(N) ) is a key to valuate the process design purposes. The paper presents the results obtained by applying artificial neural networks to predict productivity (W(N),S ) for earthmoving machinery systems, consisting of c excavators and N haulers. Experimentally determined productivity values can form a standard basis for designing construction earthworks. Possessing the data set consisting of the technical parameters of earthmoving machinery systems and the corresponding productivities for different output hauling distances, one can train artificial neural networks and use subsequently for the reliable prediction of W(N),S .
REGULARITIES IN PROPAGATION OF OPENED CORROSION‐INDUCED CRACKS IN CONCRETE
Authors: Jokūbaitis Vidmantas
Published: January 2019

Long and short‐term (accelerated with simulation of pressure developed by compressed rust) experimental investigations were accomplished. It was investigated in long‐term tests the relationship between the width of the longitudinal cracks on the concrete surface and close to the reinforcement, and relation between these widths and corrosion‐induced damages in the reinforcement; parameters of these relationships were established. In short‐time investigations it was tried to clarify the influence of transverse reinforcement and opened normal cracks on the nature of longitudinal cracks propagation. It has been determined that the character and the rate of propagation of the longitudinal cracks depend on distribution of transverse reinforcement and normal cracks along a member.
TIME BUFFERS IN CONSTRUCTION PROCESS SCHEDULING
Authors: Rogalska Magdalena , Hejducki Zdzisław
Published: January 2019

Potential applications of the CCS/BM method in the scheduling of continuous LSM (Linear Scheduling Model) construction activities are considered. The effect of time buffers – feeding buffers (FB) and project buffers (PB) – on total project realisation time (TT) is examined. Feeding buffers are found to have no direct full influence on TT if construction activities continuity is assumed. The influence of FBs on TT for other conditions considered in this paper still needs to be examined.
LIMIT PERIOD BASED ON APPROXIMATE ANALYTICAL METHODS ESTIMATING INELASTIC DISPLACEMENT DEMANDS OF BUILDINGS
Authors: Djebbar Nabil , Chikh Nasr-Eddine
Published: January 2019

The Algerian seismic design code (RPA99) recommends a limit on the elastic period as a governing factor in the design process of low and mid‐rise buildings, function of the structural system regardless of the related ductility level. The recommended limit criterion is evaluated through approximate analytical methods using drift limit. The assignable displacement ductility ratio for the force reduction factor is derived from some well established R‐μ‐Tn expressions. The limit period evaluation procedure (proposed in this paper) agrees with a capacity design approach since it allows for adjusting the required resistance demand level function of a ductility level resulting from code's steel recommendations. This will enhance seismic design procedure based on a target‐period approach such as in the Algerian seismic design code RPA99, to fulfil the minimum required two performance levels or to satisfy three performance levels if a damage control is considered. A critical study is carried out considering three regular earthquake‐resistant concrete framed structures and taking into account the specificity of various types of soils, namely rock, firm and soft. A comparison of the obtained results shows clearly that the RPA99 recommended limit is only valid for nude moment resisting frames.
MODIFIED ASPHALT MIXTURES RESISTANCE TO PERMANENT DEFORMATIONS
Authors: Radziszewski Piotr
Published: January 2019

Permanent deformations, primarily in the form of ruts, are one of the basic asphalt pavement damages impairing its service properties. Application of appropriate asphalt mixtures and binder modification are effective methods for improving asphalt courses resistance. While being manufactured, stored, fitted into a road pavement and during long term service, bitumen binders and asphalt mixtures are subject to continuous unfavourable ageing processes during which pavement courses characteristics change considerably, resistance to permanent deformations being among them. This article presents rut and dynamic creep test results of concrete, SMA (stone mastic asphalt), MNU (thin courses of non‐continuous grain mixtures), Superpave mixture and porous asphalt mixture of two air void content percentages: 15 %, 20 %. Asphalt concrete mixtures, MNU's and porous asphalt mixtures contained elastomer, plastomer and fine rubber modified binders. Samples for laboratory rut tests were made by slab compaction because this method, as the author's previous research had shown, was the closest to ‘in‐situ’ conditions. Resistance to permanent deformations of the examined specimens was evaluated before aging, after technological aging (short term ageing) and after service ageing (long‐term ageing). The test results show that resistance to permanent deformations depends on the kind of asphalt mixture and binder applied. Concrete asphalts with fine rubber modified bitumens and concrete asphalts with 7 % polymer modified binders as well as SMA's and Superpave mixtures with unmodified binders appeared to be most resistant to permanent deformations after a long‐term laboratory ageing. It was proved that the overall evaluation of resistance to permanent deformations could be obtained by rut and creep testing of asphalt mixtures exposed to short‐ and long‐term ageing. Simultaneous determining 4 parameters: maximum rut depth after short‐term ageing, rutting coefficient after operational ageing, stiffness creeping modulus after long‐term ageing and cumulated deformation after short‐term ageing, facilitates full characteristics of modified asphalt mixes designed to be built in the wearing course of a road pavement.
MRI and Dose Selection in a Phase II Trial of Baricitinib with Conventional Synthetic Disease-modifying Antirheumatic Drugs in Rheumatoid Arthritis
Authors: Peterfy Charles , DiCarlo Julie , Emery Paul , Genovese Mark C. , Keystone Edward C. , Taylor Peter C. , Schlichting Doug E. , Beattie Scott D. , Luchi Monica , Macias William
Published: January 2019

Objective.

Magnetic resonance imaging (MRI) was used in a phase IIb study of baricitinib in patients with RA to support dose selection for the phase III program.

Methods.

Three hundred one patients with active RA who were taking stable methotrexate were randomized 2:1:1:1:1 to placebo or once-daily baricitinib (1, 2, 4, or 8 mg) for up to 24 weeks. One hundred fifty-four patients with definitive radiographic erosion had MRI of the hand/wrist at baseline and at weeks 12 and 24. Two expert radiologists, blinded to treatment and visit order, scored images for synovitis, osteitis, bone erosion, and cartilage loss. Combined inflammation (osteitis + 3× synovitis score) and total joint damage (erosion + 2.5× cartilage loss score) scores were calculated. Treatment groups were compared using ANCOVA adjusting for baseline scores.

Results.

Mean changes from baseline to Week 12 for synovitis were −0.10, −1.50, and −1.60 for patients treated with placebo, baricitinib 4 mg, and baricitinib 8 mg, respectively (p = 0.003 vs placebo for baricitinib 4 and 8 mg). Mean changes for osteitis were 0.00, −3.20, and −2.10 (p = 0.001 vs placebo for baricitinib 4 mg and p = 0.037 for 8 mg), respectively. Mean changes for bone erosion were 0.90, 0.10, and 0.40 (p = 0.089 for 4 mg and p = 0.275 for 8 mg), respectively, in these treatment groups.

Conclusion.

MRI findings in this subgroup of patients suggest suppression of synovitis, osteitis, and combined inflammation by baricitinib 4 and 8 mg. This corroborates previously demonstrated clinical efficacy of baricitinib and increases confidence that baricitinib 4 mg could reduce the radiographic progression in phase III studies. [Clinical trial registration number (www.ClinicalTrials.gov):NCT01185353]
Predictors of Effectiveness of Anakinra in Systemic Juvenile Idiopathic Arthritis
Authors: Saccomanno Benedetta , Tibaldi Jessica , Minoia Francesca , Bagnasco Francesca , Pistorio Angela , Guariento Andressa , Caorsi Roberta , Consolaro Alessandro , Gattorno Marco , Ravelli Angelo
Published: January 2019

Objective.

To seek predictors of therapeutic response to the interleukin (IL)-1 inhibitor anakinra in children with systemic-onset juvenile idiopathic arthritis (sJIA).

Methods.

The clinical charts of all patients with sJIA who were newly treated with anakinra at our center between 2004 and 2017 were reviewed retrospectively. Predictors included baseline demographic, clinical, and laboratory variables as well as previous or concomitant therapies. The effectiveness of anakinra was assessed at 1 year after treatment start. Complete clinical response (CCR) was defined as absence of fever, physician’s global assessment ≤ 1, count of active joints ≤ 1, negative C-reactive protein, and ≥ 75% reduction of corticosteroid dose. According to the intention-to-treat principle, patients who had anakinra discontinued before 1 year for any reasons other than disease remission were classified as nonresponders. Statistics included univariate and multivariable analyses.

Results.

Of the 62 patients included in the study, 24 (39%) met the criteria for CCR at 1 year, whereas 38 (61%) did not. On multivariable analysis, independent correlations with achievement of CCR were identified for shorter disease duration, lower active joint count, higher ferritin level, and greater activity of systemic manifestations. The area under the curve of the model was 0.83.

Conclusion.

Our findings help to delineate the clinical profile of patients with sJIA who are more likely to benefit from IL-1 blockade. They also underscore the need for studies aimed at examining the therapeutic role of early IL-1 inhibition and to identify biomarkers predicting response to either IL-1 or IL-6 antagonists.
Association of Smoking and Obesity on the Risk of Developing Primary Sjögren Syndrome: A Population-based Cohort Study
Authors: Servioli Luisa , Maciel Gabriel , Nannini Carlotta , Crowson Cynthia S. , Matteson Eric L. , Cornec Divi , Berti Alvise
Published: January 2019

Objective.

To explore the role of smoking and obesity in primary Sjögren syndrome (pSS).

Methods.

Olmsted County (Minnesota, USA) residents (n = 106) diagnosed with pSS from 2000 to 2015 were compared to 3 controls without pSS and matched for age and sex who were randomly selected from Olmsted County residents.

Results.

Current smokers were less likely to be pSS cases (OR 0.34, 95% CI 0.14–0.85), while there was no association between former smoking and case/control status (OR 1.27, 95% CI 0.80–2.03) compared to never smokers. Smoking status was not associated with antinuclear antibody, anti-SSA, anti-SSB, or rheumatoid factor positivity (p > 0.05). OR for obesity was 0.79 (95% CI 0.48–1.30).

Conclusion.

In this population-based study, current smoking was inversely associated with case/control status, while body mass index lacked any association.