bluuebunny/crossref_metadata_2025 huggingface dataset:
Conceptualizing New Materialism in Geographical Studies of the Rural Realm
Authors: Paniagua Angel
Published: January 2023

Geographic analysis in rural areas has been dominated in recent decades by socio-economic and socio-political perspectives. The new materialism can constitute a way of progress in rural geographical studies that involve the material and the human in the form of hybrid experiences. Materiality can be expressed in three ways: (1) the surface matter that corresponds to the traditional elements of the material rural space, (2) the materiality that would be associated with a joint and undifferentiated vision of human artefacts in a village, mainly the set of rural houses and (3) the experimental materiality that has an individual dimension, the result of the multiple processes of destruction, revival and reconstruction that simultaneously happen in one place. The experimental materiality is of the most interest for geographic analysis since it is where the materiality of the rural house and the individual are hybridized in the process of recovery of the traditional rural house. In the process of recovery of materialities, binary oppositions built in the rigid framework of modernity can be dissolved and established fluid postmodern alternatives co-produced between people and materiality. The new materialism in rural geography can be an alternative path that allows analyzing heterogeneous realities in a hybrid way and contributing in a practical context to the development of new rural policies.
The Role of Wastewater in Controlling Fluvial Erosion Processes on Clayey Bedrock
Authors: Bufalini Margherita , Aringoli Domenico , Bendia Fabrizio , Farabollini Piero , Gentilucci Matteo , Lampa Francesco , Martinello Chiara , Materazzi Marco , Pambianchi Gilberto
Published: January 2023

In recent decades, fluvial erosion processes in highly anthropized areas are mainly associated with in-stream gravel mining activities or with the presence of artificial reservoirs which have increased the erosive capacity of the river as a consequence of the reduced sediment transport or the modification of the longitudinal profile of the channel. On the other hand, the role of pollutants in the degradation processes of soils with a predominantly clayey component is little known. The present study, through chemical analyses of water and mineralogical–geotechnical analyses of clayey soil samples taken along some river channels in central Italy in correspondence with water treatment plants, highlights how “polluting” elements present in the water can modify the crystalline lattice and consequently, the resistance parameters of the soil itself, making it more susceptible to erosion processes. In particular, significant are the variations of the Plasticity Index, which tends to double in all the samples and the transformations of clayey minerals such as illite and kaolinite, toward montmorillonite and smectite, with consequent breaking of the ionic bonds and decrease of the material cohesion. Although in the cases studied this phenomenon was quantitatively less relevant than the “mechanical” processes described above, it could have a greater impact in the presence of landfills or large production settlements (agricultural or industrial) where the concentration of pollutants can be substantial.
Primary Large B-Cell Lymphoma of Immune-Privileged Sites of the Cerebellum: A Case Series and Review of the Literature
Authors: Pancetti Saverio , Rahal Daoud , Fernades Bethania , Galli Carlo , Uccella Silvia , Terracciano Luigi Maria , Pessina Federico , Bello Lorenzo , Bonometti Arturo
Published: January 2023

Primary large B-cell lymphoma of immune-privileged sites (IP-LBCL) is a rare malignant hematological neoplasm. Involvement of the cerebellum is even rarer and its diagnosis is often difficult to make due to its non-specific clinical and radiological presentation. Methods: We reported 3 cases of cerebellar IP-LBCL followed at our hospital and reviewed the medical literature to unravel the peculiarities of this poorly studied entity. Outcomes: Analyzing our cases and reviewing the literature, we could collect and study 26 cases of cerebellar IP-LBCL. To the best of our knowledge, this is the largest cohort of such patients currently published. Conclusion: Cerebellar IP-LBCL presents more often in adult females with cerebellum-related focal neurological signs such as ataxia, headache, and nausea. Histological confirmation is mandatory for a correct diagnosis and treatment and all cases feature diffuse large B-cell lymphoma histopathology. Compared to other encephalic IP-LBCL, cerebellar cases seem to include a higher number of cases with germinal center B-cell phenotype and better survival. These differences may be related to a different immune microenvironment and especially immunoregulation that distinguishes the cerebellum from other areas of the CNS.
Development and Diversity of Epibiont Assemblages on Cultivated Sugar Kelp (Saccharina latissima) in Relation to Farming Schedules and Harvesting Techniques
Authors: Corrigan Sophie , Brown A. Ross , Tyler Charles R. , Wilding Catherine , Daniels Carly , Ashton Ian G. C. , Smale Dan A.
Published: January 2023

Seaweed farming in Europe is growing and may provide environmental benefits, including habitat provisioning, coastal protection, and bioremediation. Habitat provisioning by seaweed farms remains largely unquantified, with previous research focused primarily on the detrimental effects of epibionts, rather than their roles in ecological functioning and ecosystem service provision. We monitored the development and diversity of epibiont assemblages on cultivated sugar kelp (Saccharina latissima) at a farm in Cornwall, southwest UK, and compared the effects of different harvesting techniques on epibiont assemblage structure. Increases in epibiont abundance (PERMANOVA, F4,25 = 100.56, p < 0.001) and diversity (PERMANOVA, F4,25 = 27.25, p < 0.001) were found on cultivated kelps over and beyond the growing season, reaching an average abundance of >6000 individuals per kelp plant with a taxonomic richness of ~9 phyla per kelp by late summer (August). Assemblages were dominated by crustaceans (mainly amphipods), molluscs (principally bivalves) and bryozoans, which provide important ecological roles, despite reducing crop quality. Partial harvesting techniques maintained, or increased, epibiont abundance and diversity beyond the farming season; however, these kelp plants were significantly fouled and would not be commercially viable in most markets. This paper improves understanding of epibiont assemblage development at European kelp farms, which can inform sustainable, ecosystem-based approaches to aquaculture.
Martensitic Transformation Temperatures and Hall Effect in Ni47−xMn41+xIn12 (x = 0, 1, 2) Alloys
Authors: Marchenkov Vyacheslav V. , Emelyanova Sabina M. , Marchenkova Elena B.
Published: January 2023

At present, the question of the relationship between the characteristic martensitic transformation temperatures (MTT) and the electronic parameters of a system has not been fully studied. In the present work, an attempt to establish a similar relationship using the example of the concentration of charge carriers, n, was made. The field dependences of Hall resistivity ρH and magnetization M of the magnetocaloric Ni47−xMn41+xIn12 (x = 0, 1, 2) alloys were measured at T = 4.2 K and in magnetic fields of up to 80 kOe. The MTT were obtained from the temperature dependences of electrical resistivity and magnetization. It was observed that the MTT correlate strongly with both the valence electron concentration e/a and the electronic transport characteristics, which are the coefficient of the normal (NHE) R0 and anomalous (AHE) RS Hall effect and the concentration of charge carriers n.
Printing via Laser-Induced Forward Transfer and the Future of Digital Manufacturing
Authors: Florian Camilo , Serra Pere
Published: January 2023

In the last decades, digital manufacturing has constituted the headline of what is starting to be known as the ‘fourth industrial revolution’, where the fabrication processes comprise a hybrid of technologies that blur the lines between fundamental sciences, engineering, and even medicine as never seen before. One of the reasons why this mixture is inevitable has to do with the fact that we live in an era that incorporates technology in every single aspect of our daily lives. In the industry, this has translated into fabrication versatility, as follows: design changes on a final product are just one click away, fabrication chains have evolved towards continuous roll-to roll processes, and, most importantly, the overall costs and fabrication speeds are matching and overcoming most of the traditional fabrication methods. Laser-induced forward transfer (LIFT) stands out as a versatile set of fabrication techniques, being the closest approach to an all-in-one additive manufacturing method compatible with virtually any material. In this technique, laser radiation is used to propel the material of interest and deposit it at user-defined locations with high spatial resolution. By selecting the proper laser parameters and considering the interaction of the laser light with the material, it is possible to transfer this technique from robust inorganic materials to fragile biological samples. In this work, we first present a brief introduction on the current developments of the LIFT technique by surveying recent scientific review publications. Then, we provide a general research overview by making an account of the publication and citation numbers of scientific papers on the LIFT technique considering the last three decades. At the same time, we highlight the geographical distribution and main research institutions that contribute to this scientific output. Finally, we present the patent status and commercial forecasts to outline future trends for LIFT in different scientific fields.
Effect of Mg Addition and PMMA Coating on the Biodegradation Behaviour of Extruded Zn Material
Authors: Diaa Alia A. , El-Mahallawy Nahed , Shoeib Madiha , Lallemand Nicolas , Mouillard Flavien , Masson Patrick , Carradò Adele
Published: January 2023

Although zinc (Zn) is one of the elements with the greatest potential for biodegradable uses, pure Zn does not have the ideal mechanical or degrading properties for orthopaedic applications. The current research aims at studying the microstructure and corrosion behaviour of pure Zn (used as a reference material) and Zn alloyed with 1.89 wt.% magnesium (Mg), both in their extruded states as well as after being coated with polymethyl methacrylate (PMMA). The grafting-from approach was used to create a PMMA covering. The “grafting-from” method entails three steps: the alkali activation of the alloys, their functionalization with an initiator of polymerization through a phosphonate-attaching group, and the surface-initiated atom transfer radical polymerisation (SI-ATRP) to grow PMMA chains. Electrochemical and immersion corrosion tests were carried out in a simulated body fluid (SBF), and both confirmed the enhanced corrosion behaviour obtained after coating. The electrochemical test revealed a decrease in the degradation rate of the alloy from 0.37 ± 0.14 mm/y to 0.22 ± 0.01 mm/y. The immersion test showed the ability of complete protection for 240 h. After 720 h of immersion, the coated alloy displays minute crevice corrosion with very trivial pitting compared to the severe localized (galvanic and pitting) corrosion type that was detected in the bare alloy.
Thermal Elastohydrodynamic Analysis of a Worm Gear
Authors: Tošić Marko , Larsson Roland , Stahl Karsten , Lohner Thomas
Published: January 2023

This study explores the elastohydrodynamic lubrication (EHL) between the contacting tooth flanks of a worm gear with nonconjugate meshing action. The contact is characterized by a slender-like elliptical shape and high sliding. The geometry and contact conditions for the considered worm gear were obtained using tooth contact analysis. Based on that, the complete area of the worm gear contact was analyzed using a validated numerical EHL model considering non-Newtonian, thermal, and transient effects. The geometrical and kinematic design factors that influence EHL film formation in worm gears were identified and discussed. The results show the specific characteristics of worm gear EHL contacts, such as the very slender contact in the tooth root flank area, which diminishes the effect of the entrainment speed on film thickness. EHL film formation could be supported by increasing conformity between the flanks to make the contact less slender. By comparing the film thickness results against analytically obtained ones, relatively large differences were observed except for one formula for minimum film thickness.
Narrow Tilting Vehicle Drifting Robust Control
Authors: Xu Dongxin , Han Yueqiang , Han Xianghui , Wang Ya , Wang Guoye
Published: January 2023

The narrow tilting vehicle receives extensive public attention because of traffic congestion and environmental pollution, and the active rolling motion control is a traffic safety precaution that reduces the rollover risk caused by the structure size of the narrow vehicle. The drifting motion control reflects the relatively updated attentive research of the regular-size vehicle, which can take full advantage of the vehicle’s dynamic performance and improve driving safety, especially when tires reach their limits. The narrow tilting vehicle drifting control is worthy of research to improve the driving safety of the narrow tilting vehicle, especially when tires reach the limit. The nonlinear narrow tilting vehicle dynamic model is established with the UniTire model to describe the vehicle motion characteristics and is simplified to reduce the computation of the drifting controller design. The narrow tilting vehicle drifting controller is designed based on the robust theory with uncertain external disturbances. The controller has a wide application, validity, and robustness and whose performance is verified by realizing different drifting motions with different initial driving motions. The narrow tilting vehicle drifting robust control has some practical and theoretical significance for more research.
Two-Step Enzymolysis of Antarctic Krill for Simultaneous Preparation of Value-Added Oil and Enzymolysate
Authors: Teng Xin-Nan , Wang Shu-Chang , Zeb Liaqat , Dong Yue-Sheng , Xiu Zhi-Long
Published: January 2023

Antarctic krill is a crucial marine resource containing plenty of high-valued nutrients. However, krill oil as a single product has been developed by the current solvent extraction with high cost. From the perspective of comprehensive utilization of Antarctic krill, this study proposed a novel two-step enzymolysis-assisted extraction in attempt to produce value-added oil and enzymolysate simultaneously. After two-step chitinase/protease hydrolysis, the lipid yield increased from 2.09% to 4.18%, reaching 112% of Soxhlet extraction. The method greatly improved the yields of main components while reducing the impurity content without further refining. After optimization, the oil contained 246.05 mg/g of phospholipid, 80.96 mg/g of free eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), and 0.82 mg/g of astaxanthin. The by-product enzymolysate was abundant in water-soluble proteins (34.35 mg/g), oligopeptides (13.92 mg/g), amino acids (34.24 mg/g), and carbohydrates (5.79 mg/g), which was a good source of functional nutrients. In addition, both oil and enzymolysate showed high antioxidant capacity. This novel method could simultaneously provide oil and enzymolysate amounting for 58.61% of dried krill.
Preparation of Lateral Flow PVDF Membrane via Combined Vapor- and Non-Solvent-Induced Phase Separation (V-NIPS)
Authors: Wang Xiaoyun , Chen Dejian , He Ting , Zhou Yue , Tian Li , Wang Zhaohui , Cui Zhaoliang
Published: January 2023

A large pore size Poly(vinylidene fluoride) (PVDF) membrane was prepared by the V-NIPS method using PVDF/N, N-dimethylacetamide (DMAc)/Polyvinyl pyrrolidone (PVP)/Polyethylene glycol (PEG) system. Firstly, the effect of different additive ratios on the membrane morphology and pore size was studied, and it was found that when the PVP:PEG ratio was 8:2, PVDF membranes with a relatively large pore size tend to be formed; the pore size is about 7.5 µm. Then, the effects of different exposure time on the membrane morphology and pore size were investigated, and it was found that as the vapor temperature increased, the pores on the surface of the membrane first became slightly smaller and then increased. Finally, the effects of different vapor temperatures on the membrane properties were discussed. The results showed that the as-prepared membrane exhibited suitable capillary flow rate and similar performance compared with a commercially available membrane in colloidal gold tests. The likely cause is that the amount of negative charge is less and the capillary migration rate is too fast. This paper provides a reference for the preparation of PVDF colloidal gold detection membrane.
Influence of Honing Parameters on the Quality of the Machined Parts and Innovations in Honing Processes
Authors: Sender Piotr , Buj-Corral Irene
Published: January 2023

The article presents a literature review dealing with the effect of the honing parameters on the quality of the machined parts, as well as with the recent innovations in honing processes. First, an overview about the honing and the plateau-honing processes is presented, considering the main parameters that can be varied during machining. Then, the influence of the honing parameters on surface finish, shape deviation and material removal rate is presented. Finally, some special and innovative applications of the honing process are described. For example, honing with variable kinematics allows obtaining oil grooves that are not rectilinear but curvilinear, in order to reduce the temperature of the part during machining and thus achieving better surface finish and lower shape deviation. Automation of the honing machines is useful to improve both the production and the verification process. Another innovation consists of using 3D printed tools in honing processes, which will help to obtain abrasive tools with complex shapes, for example by means of powder bed fusion processes.
Computational Analysis of Machining Induced Stress Distribution during Dry and Cryogenic Orthogonal Cutting of 7075 Aluminium Closed Cell Syntactic Foams
Authors: Thomas Kevin K. , Kannan Sathish , Pervaiz Salman , Nazzal Mohammad , Karthikeyan Ramanujam
Published: January 2023

The addition of hollow aluminium oxide bubbles to the 7075 aluminium matrix results in a lightweight syntactic foam with a reduced density and an increased peak compression strength. The presence of ceramic bubbles also aids in a reduced coefficient of thermal expansion and thermal conductivity in comparison to aluminium alloys. In spite of their enhanced material properties, the inclusion of hollow aluminium oxide bubbles presents the challenge of poor machinability. In order to elucidate the problem of poor surface machinability, an attempt has been made to develop a thermo-mechanical finite element machining model using AdvantEdgeTM software with which surface quality and machined syntactic foam material can be analyzed. If the novel model developed is combined with virtual reality technology, CNC technicians can observe the machining results to evaluate and optimize the machining program. The main novelty behind this software is that the material foam is assumed as a homogeneous material model for simplifying the material model as a complex heterogeneous material system. The input parameters used in this study are cutting speed, feed, average size and volume fraction of hollow aluminium oxide bubbles, and coolant. For the output parameters, the numerical analysis showed a 6.24% increase in peak tensile machining induced stress as well as a 51.49% increase in peak cutting temperature as cutting speed (25 m/min to 100 m/min) and uncut chip thickness (0.07 mm to 0.2 mm) were increased. The average size and volume fraction of hollow aluminium oxide bubbles showed a significant impact on the magnitude of cutting forces and the depth of tensile induced stress distribution. It was observed on the machined surface that, as the average size of hollow aluminium oxide bubbles became coarser, the peak machining induced tensile stress on the cut surface reduced by 4.47%. It was also noted that an increase in the volume fraction of hollow aluminium oxide bubbles led to an increase in both the peak machining induced tensile stress and the peak cutting temperature by 29.36% and 20.11%, respectively. This study also showed the influence of the ceramic hollow bubbles on plastic deformation behavior in 7075 aluminium matrix; the machining conditions for obtaining a favorable stress distribution in the machined surface and sub-surface of 7075 closed cell syntactic foam are also presented.
Tabletop 360-Degree Three-Dimensional Light-Field Display Based on Viewpoint-Fitting Encoding Algorithm for Reducing Facet Braiding
Authors: Wang Peiren , Bi Jinqiang , Li Zilong , Yan Binbin , Li Zhengyang , Wang Xiaozheng , Liu Li
Published: January 2023

Since the effect of the facet braiding phenomenon, the display quality of reconstructed image degrades with increasing depth of field in tabletop three-dimensional light-field display. Here, to analysis the facet braiding, the imaging process of the tabletop 360-degree three-dimensional light-field display based on conical lens array is mathematically modeled. A viewpoint-fitting encoding algorithm is proposed to reduce the effect of the facet-braiding phenomenon and improve the range of depth of field, which is optimized to form the best synthetic encoded image by fitting the reconstructed image seen by the simulated human eye to the parallax image captured at the corresponding location. The effectiveness of the proposed optimization algorithm is verified by simulation analysis and optical experiments, respectively. In the experiment, the clear depth of field range of the display system is increased from 13 cm to 15 cm, and the visualization effect of the reconstructed three-dimensional image is enhanced.
Impact of COVID-19 on Uro-Oncological Patients: A Comprehensive Review of the Literature
Authors: Gavi Filippo , Santoro Paolo Emilio , Amantea Carlotta , Russo Pierluigi , Marino Filippo , Borrelli Ivan , Moscato Umberto , Foschi Nazario
Published: January 2023

Background: The aim of this paper is to discuss the impact of COVID-19 on patients with urological malignancies (prostate cancer, bladder and upper tract urothelial cancer, kidney cancer, penile and testicular cancer) and to review the available recommendations reported in the literature. Methods: A review was performed, through the PubMed database, regarding available recommendations reported in the literature, to identify studies examining the impact of COVID-19 on treatment and clinical outcomes (including upstaging, recurrence, and mortality) for uro-oncological patients. Results: The COVID-19 pandemic dramatically changed the urological guidelines and patients’ access to screening programs and follow-up visits. Great efforts were undertaken to guarantee treatments to high-risk patients although follow up was not always possible due to recurrent surges, and patients with lower risk cancers had to wait for therapies. Conclusions: Physically and mentally, uro-oncological patients paid a heavy price during the COVID-19 pandemic. Long term data on the “costs” of clinical decisions made during the COVID-19 pandemic are still to be revealed and analyzed.
Attenuation of Skeletal Muscle Atrophy Induced by Dexamethasone in Rats by Teaghrelin Supplementation
Authors: Jhuo Cian-Fen , Hsieh Sheng-Kuo , Chen Wen-Ying , Tzen Jason T. C.
Published: January 2023

Muscle atrophy caused by an imbalance between the synthesis and the degradation of proteins is a syndrome commonly found in the elders. Teaghrelin, a natural compound from oolong tea, has been shown to promote cell differentiation and to inhibit dexamethasone-induced muscle atrophy in C2C12 cells. In this study, the therapeutic effects of teaghrelin on muscle atrophy were evaluated in Sprague Dawley rats treated with dexamethasone. The masses of the soleus, gastrocnemius and extensor digitorum longus muscles were reduced in dexamethasone-treated rats, and the reduction of these muscle masses was significantly attenuated when the rats were supplemented with teaghrelin. Accordingly, the level of serum creatine kinase, a marker enzyme of muscle proteolysis, was elevated in dexamethasone-treated rats, and the elevation was substantially reduced by teaghrelin supplementation. A decrease in Akt phosphorylation causing the activation of the ubiquitin–proteasome system and autophagy for protein degradation was detected in the gastrocnemius muscles of the dexamethasone-treated rats, and this signaling pathway for protein degradation was significantly inhibited by teaghrelin supplementation. Protein synthesis via the mTOR/p70S6K pathway was slowed down in the gastrocnemius muscles of the dexamethasone-treated rats and was significantly rescued after teaghrelin supplementation. Teaghrelin seemed to prevent muscle atrophy by reducing protein degradation and enhancing protein synthesis via Akt phosphorylation.
Triterpenoid and Steroid Content of Lipophilic Extracts of Selected Medicinal Plants of the Mediterranean Region
Authors: Gadouche Leila , Alsoufi Abdulwadood Shakir Mahmood , Pacholska Dominika , Skotarek Anna , Pączkowski Cezary , Szakiel Anna
Published: January 2023

The available phytochemical characteristics of the medicinal plants and derived herbal material often lack data concerning the content of steroids (including phytosterols) and triterpenoids, that can be responsible for various beneficial properties and therapeutic effects, either directly, or as a result of synergistic action with other bioactive constituents. The aim of the present work was the analysis of the content of these compounds in herbal material (leaves, aerial parts) derived from selected medicinal plants (Cistus ladanifer, Cistus monspeliensis, Erica arborea, Globularia alypum, Pistacia lentiscus, Rhamnus alaternus), widely used in folk medicine in the Mediterranean region. Results obtained by gas chromatography-mass spectrometry (GC-MS)-targeted profiling revealed the diversity in the profiles and contents of steroids and triterpenoids in the analyzed plant material, ranging from 5.7% d.w. in E. arborea to 0.1% in G. alypum. The obtained results supplement the existing phytochemical data of the investigated medicinal plants, pointing to the E. arborea aerial parts and P. lentiscus leaves as valuable resources of phytosterols and bioactive triterpenoids.
Characterization and Comparison of Steroidal Glycosides from Polygonatum Species by High-Performance Liquid Chromatography–Electrospray Ionization Mass Spectrometry
Authors: Liu Danyang , Kikuchi Takashi , Li Wei
Published: January 2023

Polygonatum species have been used as traditional medicines and functional foods in Asia and Europe since ancient times. In this study, a fast and simple method based on liquid chromatography coupled with electrospray ionization mass spectrometry (LC-ESI-MS) was developed to systematically analyze and identify the steroidal glycosides in four major Polygonatum species distributed in Japan, including P. odoratum, P. falcatum, P. macranthum, and P. sibiricum. As a result, 31 steroidal glycosides were tentatively identified, including 18 known and 13 previously unreported glycosides. Their structures were identified by the interpretation of chromatographic behavior and ESI-MS fragmentation patterns. The identification of 31 steroidal glycosides was indicative of a common biogenetic pathway in Polygonatum species. Our study disclosed the chemical profiling of steroidal glycosides in the plants of Polygonatum species, which will benefit better phytochemotaxonomical and phytochemical understanding and quality control for their medicinal usage.
Bioavailability of Phenolic Compounds in Californian-Style Table Olives with Tunisian Aqueous Olive Leaf Extracts
Authors: Mechi Dalel , Baccouri Bechir , Martín-Vertedor Daniel , Abaza Leila
Published: January 2023

Recent advances in biotechnology have ensured that one of the main olive tree by-products is olive leaf extract (OLE), a rich source in bioactive compounds. The aim of this work was to study the phenolic composition in different OLEs of three Tunisian varieties, namely, ‘Sayali’, ‘Tkobri’, and ‘Neb Jmel’. The in vitro biodigestibility effect after ‘Sayali’ OLE addition to Californian-style ‘Hojiblanca’ table olives was also studied. This OLE contained bioactive molecules such as hydroxytyrosol, tyrosol, oleropeine, Procianidine B1 (PB1), and p-cumaric acid. These compounds were also found in fresh olives after OLE was added. Furthermore, from fresh extract to oral digestion, the detected amount of bioavailable phenol was higher; however, its content decreased according to each phase of gastric and intestinal digestion. In the final digestion phase, the number of phenols found was lower than that of fresh olives. In addition, the phenolic content of Californian-style ‘Hojiblanca’ table olives decreased during the in vitro digestion process. The antioxidant activity of this variety decreased by 64% and 88% after gastrointestinal digestion, being the highest antioxidant capacity found in both simulated gastric and intestinal fluid, respectively. The results show us that the ‘Sayali’ variety is rich in phenolic compounds that are bioavailable after digestion, which could be used at an industrial level due to the related health benefits.
Bee Pollen and Bread as a Super-Food: A Comparative Review of Their Metabolome Composition and Quality Assessment in the Context of Best Recovery Conditions
Authors: Baky Mostafa H. , Abouelela Mostafa B. , Wang Kai , Farag Mohamed A.
Published: January 2023

Recently, functional foods have been a subject of great interest in dietetics owing not only to their nutritional value but rather their myriad of health benefits. Moreover, an increase in consumers’ demands for such valuable foods warrants the development in not only production but rather tools of quality and nutrient assessment. Bee products, viz., pollen (BP) and bread, are normally harvested from the flowering plants with the aid of bees. BP is further subjected to a fermentation process in bee hives to produce the more valuable and bioavailable BB. Owing to their nutritional and medicinal properties, bee products are considered as an important food supplements rich in macro-, micro-, and phytonutrients. Bee products are rich in carbohydrates, amino acids, vitamins, fatty acids, and minerals in addition to a myriad of phytonutrients such as phenolic compounds, anthocyanins, volatiles, and carotenoids. Moreover, unsaturated fatty acids (USFAs) of improved lipid profile such as linoleic, linolenic, and oleic were identified in BP and BB. This work aims to present a holistic overview of BP and BB in the context of their composition and analysis, and to highlight optimized extraction techniques to maximize their value and future applications in nutraceuticals.
Characterization of Chia Seeds, Cold-Pressed Oil, and Defatted Cake: An Ancient Grain for Modern Food Production
Authors: Ferreira Diana Melo , Nunes Maria Antónia , Santo Liliana Espírito , Machado Susana , Costa Anabela S. G. , Álvarez-Ortí Manuel , Pardo José E. , Oliveira Maria Beatriz P. P. , Alves Rita C.
Published: January 2023

The increasing demand for superfoods has resulted in an increase in chia seeds consumption. The reintroduction of this ancient crop in agriculture is useful to ensure food security since it can grow in high-stress conditions. The current study aimed to characterize chia seeds, cold-pressed oil, and defatted cake (the oil extraction by-product) to improve their value and to meet consumer’s expectations (low-fat products). Chia seeds presented a significantly higher energy value than cake (444 vs. 284 kcal/100 g, respectively) due to fat removal (33 vs. 7%). The cake showed higher contents of total minerals (6 vs. 5%), protein (27 vs. 18%), and fiber (48 vs. 38%) in comparison to the seeds, and was hence considered a promising food ingredient. The major fatty acid in oil, seeds, and cake was α-linolenic acid (62–66%), and the vitamin E content was 409, 200, and 44 mg/kg, respectively. The major amino acid in the seeds and cake was glutamic acid (49 vs. 36 mg/g). The oil had a low oxidative stability (1 h), and the total phenolics content was 1.3 mg gallic acid equivalents/100 g. Chia cake incorporation in food formulations will follow consumer’s interests, and the obtained oil can be used to improve the oil supply for different applications. This approach adds value to the concept of “one health” since it includes the culture, the environment, and the consumers.
Dye-Encapsulated Metal–Organic Frameworks for the Multi-Parameter Detection of Temperature
Authors: Wan Yating , Li Yanping , Yue Dan
Published: January 2023

Temperature is an important physical parameter and plays a significant role in scientific research, the detection of which cannot be too crucial to study. In order to reduce the interference of the external environment on the detection of temperature and improve the accuracy of the detection results, a multi-parameter detection method using several optical signals was proposed. Here, a novel porous metal–organic framework (MOF), Zn-CYMPN, was synthesized and structurally characterized. Then, fluorescent organic dyes, either DPEE or DPEM, were encapsulated into the pores of Zn-CYMPN independently. The successful synthesis of the composites Zn-CYMPN⊃DPEE or Zn-CYMPN⊃DPEM could easily introduce other fluorescent centers into the original material and made it more convenient to realize multi-parameter temperature detection. More specifically, when the temperature changed, the maximum fluorescent emission wavelength (W) and the maximum optical intensity (I) of the Zn-CYMPN⊃DPEE/DPEM both showed good linear responses with temperature over a wide range, indicating that the composites were highly sensitive thermometers with multi-parameter temperature readouts. In addition, the quantum efficiency and thermal stability of the organic dyes, which bother every researcher, were improved as well.
Structure, Optical and Magnetic Properties of Two Isomeric 2-Bromomethylpyridine Cu(II) Complexes [Cu(C6H9NBr)2(NO3)2] with Very Different Binding Motives
Authors: Garci Fatma , Chebbi Hammouda , Rouzbeh Nahal , Rochels Leonhard , Disch Sabrina , Haseloer Alexander , Sebastian Sean S. , Ruschewitz Uwe , Anthony Eric Tobechukwu , Klein Axel , Zid Mohamed Faouzi
Published: January 2023

Two isomeric 2-bromomethylpyridine Cu(II) complexes [Cu(C6H9NBr)2(NO3)2] with 2-bromo-5-methylpyridine (L1) and 2-bromo-4-methylpyridine (L2) were synthesized as air-stable blue materials in good yields. The crystal structures were different with [Cu(L1)2(NO3)2] (CuL1) crystallizing in the monoclinic space group P21/c, while the 4-methyl derivative CuL2 was solved and refined in triclinic P1¯. The orientation of the Br substituents in the molecular structure (anti (CuL1) vs. syn (CuL2) conformations) and the geometry around Cu(II) in an overall 4 + 2 distorted coordination was very different with two secondary (axially elongated) Cu–O bonds on each side of the CuN2O2 basal plane in CuL1 or both on one side in CuL2. The two Br substituents in CuL2 come quite close to the Cu(II) centers and to each other (Br⋯Br ~3.7 Å). Regardless of these differences, the thermal behavior (TG/DTA) of both materials is very similar with decomposition starting at around 160 °C and CuO as the final product. In contrast to this, FT-IR and Raman frequencies are markedly different for the two isomers and the UV–vis absorption spectra in solution show marked differences in the π–π* absorptions at 263 (CuL2) or 270 (CuL1) nm and in the ligand-to-metal charge transfer bands at around 320 nm which are pronounced for CuL1 with the higher symmetry at the Cu(II) center, but very weak for CuL2. The T-dependent susceptibility measurements also show very similar results (µeff = 1.98 µB for CuL1 and 2.00 µB for CuL2 and very small Curie–Weiss constants of about −1. The EPR spectra of both complexes show axial symmetry, very similar averaged g values of 2.123 and 2.125, respectively, and no hyper-fine splitting.
Probing the Influence of Surface Chemical Functionalization on Graphene Nanoplatelets-Epoxy Interfacial Shear Strength Using Molecular Dynamics
Authors: Al Mahmud Hashim , Patil Sagar U. , Radue Matthew S. , Odegard Gregory M.
Published: January 2023

In this work, a characterization study of the interfacial interaction between different types of graphene nanoplatelets and an epoxy matrix is computationally performed. To quantify the discrete mutual graphene–epoxy “interfacial interaction energy” (IIE) within the nanocomposite, molecular dynamics simulations with a reactive force field are performed on a localized model of the suggested nanocomposite. Pull-out molecular dynamics simulations are also performed to predict the interfacial shear strength between the two constituents. The results indicate a significant increase in interfacial adhesion of functionalized nanoplatelets with the hosting epoxy matrix relative to virgin graphene nanoplatelets. The obtained results also demonstrate a dramatic increase in the interfacial interaction energy (IIE) (up to 570.0%) of the functionalized graphene/epoxy nanocomposites relative to the unmodified graphene/epoxy nanocomposites. In the same context, the surface functionalization of graphene nanoplatelets with the polymer matrix leads to a significant increase in the interfacial shear strength (ISS) (up to 750 times). The reported findings in this paper are essential and critical to producing the next generation of lightweight and ultra-strong polymer-based nanocomposite structural materials.
Blue Laser for Polymerization of Bulk-Fill Composites: Influence on Polymerization Kinetics
Authors: Negovetic Mandic Visnja , Par Matej , Marovic Danijela , Rakić Mario , Tarle Zrinka , Klarić Sever Eva
Published: January 2023

The objective of this study was to compare the polymerization kinetics of bulk-fill resin composites cured with a LED-curing device and a diode laser (449 nm). Three bulk-fill composites were light-cured with constant radiation exposure at 10 J/cm2 by varying radiant exitance and curing time. The following three light-curing protocols were used: (I) 3300 mW/cm2 for 3 s; (II) 2000 mW/cm2 for 5 s; and (III) 1000 mW/cm2 for 10 s. The degree of conversion (DC) was monitored in real time at a data acquisition rate of 2 spectra/s over a 5-min period and again after seven days using Fourier transform infrared spectroscopy. DC amounted to 30.9–61.7% at 4-mm depth after 5 min. DC values of two sculptable composites were significantly higher with the laser, regardless of the curing protocol used, but not for the flowable composite. The maximum polymerization rate (2.0–22.1%/s) was less affected by the type of curing device for one of the composites, while the other two composites achieved significantly higher values when cured with the laser. Laser curing generally increased the DC and the maximum polymerization rate while it shortened the onset of the maximum reaction rate. New handheld laser devices with adjustable power have the potential to be used as a photopolymerization light source for new generations of bulk-fill composites.
Long Non-Coding RNA Expression in Alpha-1 Antitrypsin Deficient Monocytes Pre- and Post-AAT Augmentation Therapy
Authors: Smith Stephen G. J. , Greene Catherine M.
Published: January 2023

Long non-coding RNAs (lncRNAs) regulate gene expression. Their expression in alpha-1 antitrypsin (AAT) deficiency has not been investigated. Treatment of AAT deficiency involves infusion of plasma-purified AAT and this augmentation therapy has previously been shown to alter microRNA expression in monocytes of AAT-deficient (ZZ) individuals. Here, we assess the effect of AAT augmentation therapy on the lncRNA expression profile in ZZ monocytes. Peripheral blood monocytes were isolated from ZZ individuals pre (Day 0)- and post (Day 2)-AAT augmentation therapy. Arraystar lncRNA microarray profiling was performed; a total of 17,761 lncRNAs were detectable across all samples. The array identified 7509 lncRNAs with differential expression post-augmentation therapy, 3084 were increased and 4425 were decreased (fold change ≥ 2). Expression of many of these lncRNAs were similarly altered in ZZ monocytes treated ex vivo with 27.5 μM AAT for 4 h. These properties may contribute to the manifold effects of AAT augmentation therapy.
Differential Regulation of Glucosylceramide Synthesis and Efflux by Golgi and Plasma Membrane Bound ABCC10
Authors: Iqbal Jahangir , Otaibi Abeer Al , Mubarak Sindiyan Alshaikh , Alqarni Ali , Bakillah Ahmed
Published: January 2023

Glucosylceramide (GlcCer) synthesis by the enzyme glucosylceramide synthase (GCS) occurs on the cytosolic leaflet of the Golgi and is the first important step for the synthesis of complex glycosphingolipids (GSLs) that takes place inside the lumen. Apart from serving as a precursor for glycosylation, newly synthesized GlcCer is also transported to the plasma membrane and secreted onto HDL in the circulation. The mechanism by which GlcCer is transported to HDL remains unclear. Recently, we showed that ATP-binding cassette transporter protein C10 (ABCC10) plays an important role in the synthesis and efflux of GlcCer in Huh-7 cells. In this study, we found that treatment of Huh-7 cells with an ABCC10 inhibitor, sorafenib, decreased the synthesis and efflux of GlcCer. However, treatment of cells with cepharanthine reduced only the efflux, but not synthesis, of GlcCer. These results indicate that ABCC10 may regulate the synthesis and efflux of GlcCer differentially in liver cells.
SnackTrack—An App-Based Tool to Assess the Influence of Digital and Physical Environments on Snack Choice
Authors: Valenčič Eva , Beckett Emma , Collins Clare E. , Koroušić Seljak Barbara , Bucher Tamara
Published: January 2023

As food choices are usually processed subconsciously, both situational and food environment cues influence choice. This study developed and tested a mobile app to investigate the association between physical and digital environments on snack choices. SnackTrack was designed and used to collect data on the snack choices of 188 users in real-life settings during an 8-week feasibility trial. The app asks users to take a photo of the food they are planning to consume and to provide additional information regarding the physical environment and context in which this food was eaten. The app also displayed various user interface designs (i.e., different background images) to investigate the potential effects of images on snack choice. Preliminary results suggest that the time of snack obtainment did not have a significant effect on the healthfulness of the snacks chosen. Conversely, it was found that unhealthy background images appeared to encourage healthier snack choices. In conclusion, despite consumers having the knowledge to make healthy choices, environmental cues can alter food choices. SnackTrack, a novel tool to investigate the influence of physical and digital environments on consumers’ food choices, provides possibilities for exploring what encourages (un)healthy eating behaviours.
Postoperative Probiotics Administration Attenuates Gastrointestinal Complications and Gut Microbiota Dysbiosis Caused by Chemotherapy in Colorectal Cancer Patients
Authors: Huang Feng , Li Shengjie , Chen Wenjie , Han Yiyang , Yao Yue , Yang Liang , Li Qiang , Xiao Qun , Wei Jing , Liu Zhaoxia , Chen Tingtao , Deng Xiaorong
Published: January 2023

The current study aims to evaluate the potential roles of taking probiotics postoperatively in attenuating the gastrointestinal complications and disturbed gut microbiota in colorectal cancer (CRC) patients undergoing chemotherapy. One hundred eligible CRC patients who were treated with radical surgery and needed to receive chemotherapy were recruited. Half of them were randomly assigned to the Probio group to take a probiotic combination from post-operation to the end of the first chemotherapeutic course. The other half of patients taking placebo instead were classified as the Placebo group. Gastrointestinal complications such as nausea, acid reflux, abdominal pain, abdominal distention, constipation, and diarrhea were recorded during chemotherapy. Fecal samples were collected preoperatively and after the first cycle of postoperative chemotherapy for 16S rRNA high-throughput sequencing and short-chain fatty acids (SCFAs) analysis. Results showed that probiotics administration could effectively reduce chemotherapy-induced gastrointestinal complications, particularly in diarrhea (p < 0.01). Additionally, chemotherapy also reduced the bacterial diversity indexes of the gut microbiota in CRC patients, which could be significantly increased by taking probiotics. Moreover, this chemotherapy caused significant changes in the composition of the gut microbiota, as indicated by decreased phylum levels of Firmicutes and increased Bacteroidetes, Proteobacteria, and Verrucomicrobia. In particular, several bacterial genera such as Akkermansia and Clostridium were significantly increased, while Prevotella, Lactobacillus, and Roseburia were decreased (p < 0.05). However, probiotic administration could effectively restore these taxa changes both at the phylum and genus levels, and mildly increase the genus levels of Bifidobacterium, Streptococcus, and Blautia. Furthermore, probiotics could also promote the production of SCFAs, particularly increasing acetate, butyrate, and propionate (p < 0.0001). These results support the beneficial effects of the probiotic interventions as novel alternative or complementary strategies in chemoprevention.
Consumption of Added Sugars by States and Factors Associated with Added Sugars Intake among US Adults in 50 States and the District of Columbia—2010 and 2015
Authors: Lee Seung Hee , Park Sohyun , Blanck Heidi M.
Published: January 2023

Purpose: The high intake of added sugars from foods or beverages increases the risk of obesity, hypertension, dyslipidemia, and cardiovascular disease. Because state-level data are lacking, we estimated dietary intake of added sugars by state and factors associated with intake among US adults. Design: Nationally representative, cross-sectional, in-person, household survey. Setting: 50 states and DC. Sample: 52,279 US adults from pooled data from 2010 and 2015 National Health Interview Surveys. Measures: Estimated total added sugars intake (tsp/day) using the National Cancer Institute’s scoring algorithm that converts responses from the Dietary Survey Questionnaire screener to estimated total added sugars intake (tsp/day). Analysis: Mean dietary-added sugars intake estimates and standard error were calculated for adults’ characteristics and by state for all 50 states and the District of Columbia. Differences by adult’s characteristics were assessed by pairwise t-tests (p < 0.05). All analyses accounted for complex survey design and sampling weights. Results: Overall, US adults consumed 17.0 tsp of added sugars/day (range: 14.8 tsp/day in Alaska to 1.2 tsp/day in Kentucky). Added sugars intake varied by states and sociodemographic characteristics. Conclusion: Findings may inform efforts to reduce added sugars intake to lower the high burden of chronic disease.