bluuebunny/crossref_metadata_2025 huggingface dataset:
The future of precision medicine: Integrating genetic engineering into pharmacological research
Authors: Hossen Md. Mosharraf
Published: January 2025

The integration of genetic engineering into pharmacological research is transforming the landscape of precision medicine, offering the potential to revolutionize healthcare. Precision medicine focuses on tailoring treatments to individuals based on genetic, environmental, and lifestyle factors, moving beyond the traditional “one-size-fits-all” approach. This editorial highlights the pivotal role of genetic engineering in advancing precision medicine, exploring its applications in drug discovery, pharmacogenomics, and innovative therapies such as gene and cell treatments. Tools like CRISPR-Cas9 and advancements in omics technologies have accelerated the development of personalized therapies and enhanced our understanding of disease mechanisms. Despite these breakthroughs, challenges persist. Technical hurdles like off-target effects, ethical concerns surrounding germline editing, and the high costs of these technologies must be addressed. Opportunities, however, abound—ranging from artificial intelligence-driven innovations to collaborative research initiatives, which promise to streamline the development of genetic engineering applications. This convergence of disciplines is not only reshaping drug development but also expanding the therapeutic arsenal to tackle complex diseases. With sustained investment, interdisciplinary collaboration, and an emphasis on equitable access, the promise of precision medicine—treatments tailored to each individual’s genetic blueprint—is rapidly becoming a reality.
School Heads’ Level of Performance in School Improvement Planning Journey: Basis for Enhanced Leadership and Management Program
Authors: Mutia Florabel
Published: January 2025

The school improvement plan encompasses the development of activities to help schools reach the goal of providing access to quality education. Embarking on this initiative, this study aimed to determine the level of performance of select school heads in Dinagat Islands in their journey to developing and crafting school improvement plans. The mixed-methods research design was utilized with frequency, percentage, and weighted mean. The study revealed that most school heads are at the elementary level, aged 31 to 40, and have 6 to 10 years as school heads deployed primarily in small schools, under Head Teacher positions, and with very satisfactory performance. Results revealed that school heads are classified under the Basic Level as having fair performance, with a partial understanding of the guidelines for crafting a school improvement plan. They are also categorized as Emerging school heads who fully implemented school interventions to address key result areas, thereby having a very high level of implementation in their school improvement plan. There are drawbacks and gains in crafting the enhanced school improvement plan based on supporting documents presented, adherence to policies, assessing priority improvement areas, developing projects, and alignment to key result areas. It is further recommended that with additional profile, the school heads may be upskilled with strategic planning by revisiting guidelines stipulated under DepEd Order 44 s, 2015, along with Philippine Professional Standards for School Heads indicated in DepEd Order No. 24 s, 2020, and aligned with access, quality, governance, equity, well- being and resiliency.
Classroom Management Experiences Through the Lens of Non-Education Graduate Mathematics Instructors
Authors: Pantaleon Alfred , Rodriguez Mary Joy , Villanueva ZJ , Visaya Avelina
Published: January 2025

This phenomenological research focuses on the classroom management of non-education graduate mathematics instructors in Ilocos Sur Polytechnic State College (ISPSC). The work applied transcendental phenomenological research design and purposive sampling to choose five participants with teaching experience in classroom management ranging from one to three years. Semi-structured interviews were used to elicit in-depth perspectives, and thematic analysis indicated three main themes. The three areas of significance include (1) the area of classroom management difficulties, (2) the area of classroom management approaches, and (3) the area of professional development. The study reveals the challenges educators face in their classrooms concerning the micro level of interactions, including how to address diverse student behaviors emerging from sociocultural and technological contexts. In addition, the emphasis is placed on the participants’ approaches to addressing these problems and their constant demand for relevant professional learning to enhance classroom management expertise. This study enhanced our appreciation of the difficulties of teacher learning in higher education, especially those with no educational background. It points out that much attention should be given to offering them the requisite equipment and training to preserve the joyful learning atmosphere.
Trusting in Science and Religion
Authors: Kojonen Rope
Published: January 2025

Science relies on trust both in its public reception and in the collaborative collection of evidence, as it is impossible for anyone to verify everything independently. Might the presence of trust in scientific practice help show that trust in religious matters is also rational? Or might scientific practices rather undermine testimony as a source of religious knowledge? Parallels and contrasts between scientific and religious knowledge are common in the literature, despite the plurality of sciences and religions that exist making such comparisons difficult. In this article, I will analyse science-based arguments for and against the reliability of religious testimony. I begin with Mary Midgley’s argument against scientism, and use it to develop a parallel between religious and scientific trust. I then consider two arguments from science against religious trust: the argument from the superiority of science, and the argument from cultural evolution. I argue that utilization of work in social epistemology is helpful for understanding the parallels between scientific and religious trust in a nuanced manner, and that relating specific scientific and religious practices might be more useful than general-level critiques of religious rationality.
Education, poverty and development of revival churches in the Democratic Republic of Congo: issues and perspectives
Authors:   University of Moyen-Lualaba Maniema, Congo, KIAMBU di TUEMA Jacques , KABIKISSA Florent Jean Désiré ,   Marien Ngouabi University, Congo, LOMBOTO Lomama ,   Paris 13 University of Villetaneuse, France, SAMBA Bruno ,   Marien Ngouabi University, Congo
Published: January 2025

In this article, we propose to study the proliferation phenomenon of revivalist churches in Democratic Republic of Congo (DRC), based on the analysis of the Congolese education system and its effects on poverty reduction. We show from the capacity theory developed by A. Sen that the education system applied in the DRC is less appropriate and would be favorable to the development of revival churches. To support our analysis, we use an econometric model to evaluate the main results of this study.
MАKTАBGАCHА TА’LIM YОSHIDАGI BОLАLАRNI TАRBIYАLАSHDА ZАMОNАVIY TА’LIM TEXNОLОGIYАLАRINING АHАMIYАTI
Authors: Tаngirоvа Ruhshоnа
Published: January 2025

Effective use оf educаtiоnаl technоlоgies in the preschооl educаtiоn system ensures the success оf the educаtiоnаl prоcess. The аrticle аnаlyzes the impоrtаnce оf mоdern educаtiоnаl technоlоgies аnd methоds оf their аpplicаtiоn in the educаtiоn оf preschооl children. The influence оf gаme educаtiоnаl technоlоgies оn children’s educаtiоn wаs аlsо studied.
UPAYA PENINGKATAN KEMAMPUAN BEBICARA SISWA MELALUI PENERAPAN METODE STUDENT FACILITATOR AND EXPLAINING PADA PEMBELAJARAN BAHASA INDONESIA SISWA KELAS V SDN 11 CILEGON
Authors: Aizahwa Nur Safitri  , Desty Endrawati Subroto  , Muhammad Baehaki  , Laily Fauziyah  , Ririn Maharani
Published: January 2025

Students lack of speaking ability is the background of this research. The goal is to improve students speaking skills through learning Indonesian by using the Student Facilitator and Explaining method. The approach used in this research is a descriptive qualitative approach to explain and explain in more detail related phenomena and examine more deeply from relevant references. Based on the observation, population of this study is 50 students in grade V of SDN 11 Cilegon. Students were more enthusiastic about learning to speak after using the method applied by the researcher, especially when explaining the picture. Thus, The implementation of the SAFAE method. method to students provides positive and significant results in the Indonesian language learning process. In conclusion, the implementation of this method in Indonesian language learning consistently improved student performance across sessions, as reflected in the increasing percentage of successful learning outcomes.
Influence of factors like Conflict, Progressiveness and Development, Risk Taking and Institutional Control in retention of Arts & Science Stream teachers of Degree Level Colleges
Authors: Srivastava Mamta
Published: January 2025

The Indian education system is one of the largest systems in the World. It is estimated that during the XII Five Year Plan period (2013-18), there will be a remarkable pressure of population on this system and a large number of additional students will be tapping at the doors of education institutions in the country. There is also new challenges of management and regulation being faced by these institutions, which require serious attention by both public sector and private sector institutions. Now a days private sector institutions are growing at a fast pace.

With the growing demand of education and educational institutions, public funding seemed insufficient to meet up the challenging requirement of expansion and diversification of the education system in India. This called up the situation for the rise of private educational institutions to fill this gap. This started a new era of growing number of private educational institutions getting affiliation/associated to the various State Universities in almost every part of India.
Laparoscopic Incisional Hernia Mesh Repair With And Without Defect Closure
Authors: Muhammad Yasir Mengal  , Zahid Mehmood  , Zulfiqar Ali  , Muhammad Yasir  , Sajjad Ali  , Naveed Ahmed
Published: January 2025

Objectives: As a systematic review, the present paper is designed to compare laparoscopic incisional hernia mesh repair with or without mesh defect after evaluating the rates of recurrence, complications, and postoperative recovery.
Study Design: A prospective study.
Place and duration of study: From May 2024 to October 2024 General Surgery Department Jinnah Post Graduate Medical Centre Karachi.
Methodology: 100 patients drawn through random sampling. Two groups of fifty patients each were operated, the first having Laparoscopic hernia repair with defect closure, the second having it without defect closure. Mesh positioning and location were aligned; follow-up extended to 12 months majoring on recurrence, bulge, and pain after surgery. Quantitative data analysis as well as qualitative data analysis included use of p-values and standard deviations for comparison between the groups.
Results: Table 3 demonstrated the mean times to first recurrent event; the recurrence rate in defect closure group was 6% and in non-closure group it was 10% with p value 0.04; statistically significant. New wall formation was symmetrical in 18% of patients with defect closure and 34% without (p=0.03). The mean postoperative pain scores were also comparable (3.2± 0.6 vs 3.4 ± 0.7; p=.35; not significant). There were no postsurgical complications of the noted surgery as a whole.
Conclusions: Closure of the defect in laparoscopic incisional hernia repair is associated with a lower recurrence rate and minimal bulging in comparison to non-closure laparoscopic incisional hernia repair with similar pain scores. Defect closure should be entertained for patients who desire better esthetic and clinical appearance, and the study demonstrated feasibility in patients with moderate size of hernias.
Keywords: Incisional hernia, Laparoscopy, Defect closure, Mesh repair
Fetomaternal Outcomes In Women Scheduled For C-Section In General And Spinal Anesthesia
Authors: Meerab Ilyas  , Chanda Naseem  , Waqas Ashraf  , Saima Karam Din  , Muhammad Tayyeb
Published: January 2025

Objective: Cesarean section (C-section) is one of the most routinely performed surgical procedures globally, with anesthesia having a significant role in deciding maternal and newborn outcomes.
Study Design: A Cross sectional study
Place and Duration of the Study: Study setting was Allied Health Sciences, Superior University, Lahore and duration of the study was six months jan 2024 to june 2024
Methodology: This comparative study included 100 women scheduled for elective C-sections, evenly divided into GA (n=50) and SA (n=50) groups. Demographic data, including age, BMI, parity, and gestational age, were recorded. Perioperative metrics including anesthetic induction duration, anticipated blood loss, hemodynamic stability, and recovery durations were assessed. Neonatal outcomes, encompassing APGAR scores, NICU admissions, and birth weights, were recorded.
Results: Spinal anesthesia (SA) demonstrated superior outcomes compared to general anesthesia (GA) in cesarean sections, evidenced by reduced blood loss (500 ± 80 mL vs. 600 ± 100 mL), abbreviated hospital stays (3 ± 1 days vs. 4 ± 1 days), and enhanced patient satisfaction (9.0 ± 0.8 vs. 7.5 ± 0.8). In SA, neonatal
outcomes improved with higher APGAR scores at 1 minute (8.6 ± 0.9 vs. 8.2 ± 1.1) and 5 minutes (9.8 ± 0.5 vs. 9.5 ± 0.7) and fewer NICU admissions (8% vs. 10% South Africa exhibited diminished postoperative systolic and diastolic blood pressure (120 ± 10 mmHg vs. 125 ± 12 mmHg and 72 ± 6 mmHg vs. 75 ± 7 mmHg), along with a decreased heart rate elevation (85 ± 9 beats/min vs. 90 ± 10 beats/min). SA demonstrated a reduced anesthetic induction duration (7 ± 1 min vs. 10 ± 2 min) and expedited postoperative ward transfer (10 ± 2 min vs. 15 ± 3 min). Regression analysis showed that preoperative vitals, age, BMI, and hospital stay duration predicted postoperative results. Cesarean patients exhibited enhanced perioperative stability, expedited recovery, and more satisfaction with spinal anesthesia.
Conclusion: General anesthesia (GA) causes more blood loss, slower recovery, and lower patient satisfaction than spinal anesthesia (SA) for cesarean sections. SA also improves newborn outcomes and perioperative stability.
Keyword: maternal, fetal, outcomes, Cesarean section, Spinal, General anesthesia
Efficacy Of Vacuum Assisied Dressing Technique In The Treatment Of Diabetes In Foot Ulcers
Authors: Shah Hassan  , Muhammad Hussain  , Sidra  , Abdul Basit Khan  , Adil ur Rehman  , Awais Khan
Published: January 2025

Background: Diabetic foot ulcers (DFUs) provide significant care issues due to their delayed healing durations and high complication rates. The purpose of this study is to assess the effectiveness of vacuum-assisted dressing in enhancing DFU healing and to identify factors that influence outcomes.
Objective: To determine the efficacy of vacuum assisted dressing technique in the treatment of diabetic foot ulcers.
Study Design: A quasi-experimental Study
Place and Duration of the Study: Department of Surgery, at Mardan Medical Complex Mardan from March 2024 to August 2024.
Materials and Methods: The study included 85 patients with DFUs, with an average age of 58.3 years (SD ± 12.5) and diabetes duration of 10.8 years (SD ± 6.3). Demographic, clinical, and treatment data were analyzed. The key outcomes were healing time, ulcer size decrease, pain reduction, and complication rates. Regression analysis was used to find determinants of healing.
Results: This study looked at 85 people with diabetic foot ulcers, with a mean age of 58.3 years and average diabetes duration of 10.8 years. The majority of patients (64.7%) were male, non-smokers, and had an average BMI of 28.1 kg/m². The ulcers were primarily Wagner Grade 2 (52.9%) or Grade 3 (35.3%), with an average size of 5.2 cm² and infection in 70.6%. Treatment with vacuum-assisted dressing showed significant success, with a mean healing time of 8.5 weeks and >50% ulcer size reduction in 64.7% of patients, including 29.4% who had reductions of more than 75%. Pain scores dropped by an average of 2.3 points, and problems were minor (88.2% had no adverse events). Satisfaction was high, with 70.6% reporting "Very Satisfied" and 58.8% finding the procedure "Very Easy" to use. Regression analysis showed that age, smoking, Wagner grade, ulcer size, and infection were significant predictors of healing time. Vacuum-assisted dressing considerably shortened healing time (β = -2.5, p < 0.001).
Conclusions: Vacuum-assisted dressing is a successful and patient-friendly approach for controlling DFUs that reduces healing time, ulcer size, and complications. Early intervention and addressing modifiable risk factors are crucial for achieving optimal outcomes.
Key Words: Diabetic foot ulcers, vacuum-assisted dressing, Healing
Comparison Of Single And Double-Spin Platelet- Rich Plasma Therapy For Treating Androgenetic Alopecia In Males: A Double-Blinded Randomized Controlled Trial
Authors: Syed Fareed Ahmed  , Moizza Tahir  , Saima Shahid  , Samina  , Tabinda  , Sidiqua Javaid
Published: January 2025

Objective: AGA is a type of hair loss seen predominantly in men affecting their self-image and health related quality of life. Platelet Rich Plasma (PRP) therapy is considered effective for all sorts of hair loss, including Androgenetic Alopecia (AGA) due to the presence of growth factors in PRP. However, due to variations in the procedures followed in PRP preparation, this calls for further research.
Study Design: A Randomized Control Trial.
Place and duration of the study: Study was conducted at Dermatology OPD in PEMH (Pak Emirates Military Hospital) Rawalpindi. The duration Form 01 June to 30 November 2024.
Methodology: In this study we intend to evaluate the efficacy of two different techniques of preparing PRP for treatment of patients with AGA using SALT and Likert scores. This was a Randomized Double blinded study where in 60 patients (age between 22 to 60 years) with moderate to severe Androgenetic Alopecia were randomized into Group A (single spin PRP) and Group B (double spin PRP). Treatment was administered at 0,3 and 6 weeks and later followed up at 8th week .The primary outcome measure was proportion of patients achieving mild improvement in SALT score and significant improvement in Likert score. We assessed PRP therapies containing single-spin and double-spin techniques for the treatment of AGA.
Keywords: Plasma Therapy, Hair Loss, Platelet Rich Plasma
A Clinical Review Of Aorto-Iliac And Peripheral Arterial Disease: Diagnostic Insights From Ct Angiography Findings
Authors: Athar Badshah  , Nauman Imtiaz  , Ahsin Manzoor Bhatti  , Imran Ullah  , Anas Bin Saif  , Laila Hazrat
Published: January 2025

Objectives:to evaluate the potential of CT angiography in defining the severity of aorto-iliac and peripheral arterial disease and to quantify the percentage of correct findings in anticipating clinically relevant stenosis.
Study Design: A Cross sectional study
Place and Duration of the Study: General and vascular surgeon  DHQ Hospital Batkhela and duration of the study was six months from jan 2024 to june 2024
Methodology: 50 patients suspected of having aorto-iliac and peripheral arterial diseases retrospectively. The results of diagnostic evaluation were compared against standard digital subtraction angiography as a gold standard. The degree of stenosis, the type of plaque and presence and grade of collaterals were measured in this study. To each variable, a test of significance was made using p-value; measure of variance was assessed using standard deviation (SD). Furthermore patients who underwent previous vascular interventional treatment were also excluded from the study.
Results: Of 50 patients, 38 (76% of cases) were found to have clinically relevant stenosis (> 50%) by the use of CT angiography. There was a relative symmetry of the lesion:48 ‘Right’ (SD ±10); 49 ‘Left’. Collateral formation was confirmed in the present study in 22 patients (44%). CTA stenosis measurement yielded 90% sensitivity for diagnosis when compared with conventional angiography; p < 0.01. The sensitivity and specificity of CTA were 92% and 87% respectively.
Conclusions: CT angiography procedures are quick and safe and provide accurate sensitivity and specificity results in differentiating aorto-iliac and peripheral arterial diseases. Because it can show arterial lesions, and collateral vessels, it can assist in treatment planning and may decrease the need for interventional actions.
Keywords: Aorto-iliac PAOD, peripheral arterial disease, computer tomography angiography, stenosis
Efficacy Of Probiotics In Reducing The Severity And Duration Of Neonatal Hyperbilirubinemia
Authors: Qurat Ul Ain  , Imran Mahmood  , Auruba Manshah
Published: January 2025

Objectives: To compare the mean reduction in bilirubin and mean duration of neonatal hyperbilirubinemia with probiotics in comparison with phototherapy alone for the management of neonatal hyperbilirubinemia.
Study design: A randomized controlled trial
Place and duration of study: Department of Pediatrics and Neonatology PAF Hospital, Islamabad from the period of April 20, 2024, to October 19th, 2024.
Methodology: A randomized clinical trial was carried out including a total number of 160 neonates, meeting the selection criteria. They were randomly divided into two groups of 80 neonates each by simple random sampling method. Group A (80 neonates) was given probiotics (Lactobacillus reuteri) and phototherapy (wavelength 420-450 nm) while Group B (80 neonates) was administered phototherapy alone. Dynamic serum bilirubin measurements were done serially including the baseline followed by 12, 24, and 48 hours.
Results: The mean reduction of bilirubin was 8.3 mg/dL (SD ± 1.2) in Group A and 6.5 mg/dL (SD ± 1.5) in Group B, which was statistically significant (p = 0.01). The average phototherapy duration was 2.4 days (SD ± 0.6) in Group A compared to 3.7 days (SD ± 1.0) in Group B and was statistically significant p=0.02.
Conclusions: Probiotics in combination with phototherapy are more effective in treating neonatal jaundice by decreasing the level of bilirubin and shortening the length of treatment compared to phototherapy alone.
Keywords: Newborn jaundice, probiotics, phototherapy and hyperbilirubinemia
Clinical Outcomes Of Modified Del Nido Cardioplegia In Adult And Pediatric Cardiac Surgery A Multi Center Study.
Authors: Naseeb Ur Rehman  , Chanda Naseem  , Arshad Ullah  , Azhar ayub  , Adan Naib  , Muhammad Tayyeb
Published: January 2025

Objective: This multicenter cross-sectional study evaluates the clinical outcomes of modified Del Nido cardioplegia in adult and pediatric patients undergoing cardiac surgery.
Study design: A cross-sectional study
Place and Duration of the Study: Allied Health Sciences, Superior University, Lahore, the duration of the study was six months form jan 2024 to june 2024
Methodology: A total of 194 patients (60.8% adults, 39.2% pediatrics) were included, analyzing demographic data, intraoperative parameters, and postoperative outcomes. Key metrics included CPB time, cross-clamp time, cardioplegia volume, left ventricular ejection fraction (LVEF) at discharge, and hospital stay.
Result: This study analyzed 194 patients (60.8% adults and 39.2% pediatrics) undergoing cardiac surgery, with adults having a mean age of 43.19 ± 17.65 years and pediatric patients averaging 6.51 ± 3.49 years (P = 0.001). Males predominated in both groups (41.8% adults, 22.2% pediatrics; P = 0.06), and adults exhibited higher weights (62.9 ± 15.9 kg vs. 16.6 ± 8.3 kg, P = 0.001) and body surface areas (1.63 ± 0.4 m² vs. 0.67 ± 0.2 m², P = 0.001). NYHA class I was significantly more common in pediatrics (92.1% vs. 73.7%, P = 0.005), while smoking history was exclusive to adults (18.4%, P = 0.001). Intraoperatively, adults had longer CPB times (103.2 ± 44.4 min vs. 73.53 ± 41.1 min, P = 0.001) and aortic cross-clamp times (67.5 ± 32.6 min vs. 52.2 ± 32.6 min, P = 0.002), with higher cardioplegia volume and duration (972.4 ± 427.5 ml vs. 393.7 ± 250.9 ml, P = 0.001; 62.9 ± 30.1 min vs. 48.5 ± 31.2 min, P = 0.001). Postoperatively, pediatric patients had higher LVEF at discharge (62.5 ± 4.7% vs. 55.9 ± 9.1%, P = 0.001), while hospital stays were similar (5.7 ± 1.6 days vs. 6.2 ± 2.1 days, P = 0.08). Regression analysis identified CPB time, cardioplegia volume, and cross-clamp time as significant predictors of LVEF at discharge (P < 0.001), emphasising the critical role of intraoperative management, particularly minimising CPB time, in optimising postoperative outcomes.
Conclusion: This study highlights significant differences in intraoperative and postoperative outcomes between adult and paediatric cardiac surgery patients, with CPB time, cross-clamp time, and cardioplegia volume influencing LVEF at discharge. Optimising intraoperative management is crucial to improving cardiac function and recovery in both groups.
Keyword: Modified del nido cardioplegia, Adult, pediatric, cardiac surgery, bypass
Assessing The Impact Of Personal Protective Equipment And Surgical Attire On Infection And Transmission Dynamics In Tertiary Care Hospital
Authors: Faisal Ahmad  , Tasra Bibi  , Anas Bacha Shaheen  , Fawad Ahmad  , Waleed Ahmad  , Syed Arshid Ullah
Published: January 2025

Background: Abdominal aortic aneurysms are a severe vascular disease that is mainly asymptomatic until rupture occurs. CT imaging is therefore very important in evaluating Abdominal aortic aneurysm and in helping in the surgical management of the condition. Knowledge of outcomes of patients traced by imaging and also management strategies based on the treatment approaches leads to low mortality among the affected patients.
Objectives: to analyze the results of the Abdominal aortic aneurysm  patients through CT image data, as well as to investigate how surgical treatment can potentially influence patients’ life expectancy and job recovery.
Study design: A cross-sectional study
Duration and Place of Study: Allied Health Sciences, Superior University, Lahore form jan 2024 to June 2024
Methods: 150 patients with Abdominal aortic aneurysm between the years 2013 to 2023. Demographics, CT imaging characteristics of the aneurysm (size, location), surgery type (open repair, endovascular aneurysm repair), and postoperative results were analyzed. Mean and standard deviation to describe the two groups’ success rates of the intervention were calculated with p-value to test the results for significance.
Results: Thus, endovascular aneurysm repair (EVAR) was performed in 95 patients, while open surgical repair in 55 patients out of 150 total patients. The aneurysmal diameter was mean 5.6 ± 1.2 cm in the patient population of this study The survival prediction after surgical interventions was significantly better in the EVAR group, p = 0.04. The overall complication rate was 12% with a corresponding standard deviation of 1.5%. Subsequent imaging revealed that in 87% of patients the status remained unchanged within 12 months.
Conclusions: CT imaging is an essential modality in evaluating and assessing Abdominal aortic aneurysm ; surgery, including EVAR, has relatively low rates of failure, morbidity, and mortality. Prompt diagnosis and intervention have a directly proportional relationship with the eventual outcome of the disease.
Keywords: abdominal aortic aneurysm, computed tomography, operative, endovascular repair
Politeness Strategies Used During Doctor Patient Interaction By Doctors Of Mardan Medical Complex, Mardan, Pakistan
Authors: Muhammad Muslim Khan  , Ibtisam  , Fatima  , Naila  , Izaz Jamal
Published: January 2025

Background: Medical communication, especially in multilingual contexts, relies on effective politeness strategies. Using Brown and Levinson’s Politeness Theory1, this study examines doctor-patient interactions, emphasizing communication's role in reducing disparities and improving healthcare outcomes in diverse settings.
Study Design: A Qualitative Descriptive Study.
Place of Study: Department of Psychiatry Mardan Medical Complex (MMC), Mardan from April Ist, 2023, to 30th June, 2023.
Methods and Materials: This Study a qualitative Descriptive study to collect non-numerical data from the Mardan Medical Complex in Khyber Pakhtunkhwa. The study used Snowball and convenience sampling to collect data from doctors, with 133 audio samples recorded and 88 purposively sampled. The researcher observed interactions and took notes during data collection. Two politeness models were used for data analysis: Brown and Levinson's politeness theory and Leech's politeness maxims. The results will be shared with doctors to enhance the research's fruitfulness.
Results: The study explores the strategies used by Pakistani doctors, focusing on positive politeness, bald on record, and negative politeness. Positive politeness is used to make patients comfortable and avoid threats, while bald on record is used to guide patients through health and treatment. In government sectors, tact, generosity, agreement, approbation, and sympathy are used more frequently. The study concludes that these strategies vary depending on the context and patient needs.
Conclusion: The study investigates politeness in medical discourse, focusing on doctor-patient verbal interactions in Pakistani government hospitals. It identifies a communication gap due to doctor-centered discourse, contributing to sociolinguistic use of language and workplace communication.
Keywords: Doctor-patient relationships, communication gap, politeness strategies, Mardan Medical Complex
RISCOS ASSOCIADOS AO USO PROLONGADO DE INIBIDORES DA BOMBA DE PRÓTONS: UMA REVISÃO INTEGRATIVA.
Authors: Dalchiavon Gabriel Gomes , Freitas Amel Caroline Fogaça de , Rodrigues Ana Júlia da Silva , Lima Antonio Rodrigo Sousa , Machado Clara Alves , Oliveira Fernanda Camargos Costa , Cordeiro Gabriela Lima , Rosa Hanna Bárbara Lopes , Fernandes Isabella Porto , Capeletti Julia , Rodrigues Leticia da Silva
Published: January 2025

Os inibidores da bomba de prótons (IBPs) são medicamentos amplamente utilizados para tratar condições gastrointestinais, como refluxo gastroesofágico e úlceras pépticas. Embora sejam bastante eficazes no curto prazo, o uso prolongado desses remédios pode trazer riscos à saúde, como fraturas ósseas relacionadas à osteoporose, baixos níveis de magnésio no sangue (hipomagnesemia), maior chance de pneumonia adquirida na comunidade e problemas renais. Este estudo teve como objetivo analisar, de forma crítica, as evidências disponíveis sobre os riscos associados ao uso contínuo de IBPs. Para isso, foi realizada uma revisão integrativa da literatura, considerando publicações dos últimos cinco anos em bases de dados como PubMed, SciELO e BVS. Foram incluídos estudos observacionais e de intervenção que abordassem os efeitos adversos desse tipo de tratamento. Os resultados revelaram que até 36% dos usuários crônicos de IBPs apresentaram hipomagnesemia. Além disso, o risco de fraturas aumentava proporcionalmente à dose e ao tempo de uso. Outro dado relevante foi a associação entre o uso prolongado de IBPs e infecções, como pneumonia e infecções biliares, bem como complicações renais em pacientes com outras doenças crônicas. Diante disso, concluiu-se que, apesar dos benefícios terapêuticos, o uso prolongado de IBPs exige acompanhamento médico cuidadoso. Sempre que possível, deve-se considerar estratégias para reduzir ou suspender o uso desses medicamentos. Protocolos clínicos baseados em evidências são fundamentais para garantir que os benefícios superem os riscos, promovendo um tratamento mais seguro e eficiente.
UTILIZAÇÃO DO QUESTIONÁRIO LIVERPOOL OSTEOARTHRITIS IN DOGS (LOAD) NO SERVIÇO DE ORTOPEDIA E TRAUMATOLOGIA VETERINÁRIA DA UNIVERSIDADE IGUAÇU
Authors: Silva Victória Santos da , Lubanco Bianca Gomes , Vidal Júnior André William Masseaux
Published: January 2025

A osteoartrite (OA) em cães é um desafio de saúde, muitas vezes avaliado subjetivamente. O Questionário “Liverpool Osteoarthritis in Dogs” (LOAD) é uma ferramenta objetiva com 13 itens para avaliar distúrbios articulares caninos. Os tutores preenchem o LOAD, baseando-se em suas observações, contribuindo com informações cruciais. O LOAD atribui pontuações de 0 a 4, com 0 indicando saudável e 4 significa doença grave. A pontuação geral ajuda a determinar a presença e gravidade da OA. Veterinários podem usar o LOAD para diagnóstico, monitoramento e tratamento da OA. Pode ser preenchido antes da consulta, durante a visita ou eletronicamente. O Questionário LOAD é fundamental para melhorar o diagnóstico e tratamento da OA em cães, promovendo o bem-estar desses animais. O objetivo do presente trabalho é utilizar o questionário para diagnóstico de osteoartrose e acompanhamento de pacientes caninos ao longo do tratamento instituído.
TRANSTORNO DO ESPECTRO AUTISTA (TEA) NO CONTEXTO ESCOLAR
Authors: Ferreira Eliana Lúcia , Mendonça Gisele Cristina Fernandes , Rodrigues Jeane dos Santos , Gomes Luciana
Published: January 2025

O presente texto discute os desafios encontrados no processo de inclusão e práticas pedagógicas inclusivas com estudantes com Transtorno do Espectro Autista. Vale destacar que a inclusão de alunos com TEA em ambientes escolares regulares é um tema de crescente discussão, demandando práticas pedagógicas adequadas e políticas de apoio efetivas. Neste sentido, a partir de uma revisão da literatura focando nos desafios enfrentados por estudantes, educadores e instituições de ensino. Para tanto, o objetivo consiste em identificar a partir da literatura quais tem sido as estratégias de inclusão, além das adaptações curriculares necessárias para promover um ambiente de aprendizagem eficaz com os estudantes com TEA. As discussões partem da abordagem qualitiativa e os resultados apesentados na perspectiva argumentativa e dissertativa de modo que destacam a importância de capacitar educadores e de adotar metodologias de ensino personalizadas para atender às necessidades específicas dos alunos com TEA. O que permite concluir que existe a necessidade de políticas públicas robustas que apoiem a diversidade e promovam um ambiente educativo mais inclusivo, para que se possa ter práticas inclusivas a partir das vivências e experiências escolares entre alunos com ou sem deficência, cujas relações possam contribuir para seu desenvolvimento acadêmico e social.
INSUFICIÊNCIA ADRENAL: UMA REVISÃO NARRATIVA DE LITERATURA
Authors: Costa Mariana Rodrigues , Araujo Laís Moreira Borges
Published: January 2025

As glândulas adrenais são responsáveis pela síntese de glicocorticoides, mineralocorticoides e andrógenos no seu córtex, substâncias essenciais para a homeostase do organismo. A IA (insuficiência adrenal) é um distúrbio raro definido pela produção inadequada dessas substâncias. Nesse contexto, o presente estudo tem como objetivo abordar os principais aspectos acerca da IA através de uma revisão narrativa da literatura dos principais estudos realizados nos cinco últimos anos. Os artigos foram pesquisados nas seguintes bases de dados: Biblioteca Virtual de Saúde (BVS); National Library of Medicine (PubMed MEDLINE), Google Scholar e UpToDate, sendo selecionados 18 artigos. A IA pode ser classificada como primária, secundária ou terciária dependendo do órgão acometido do eixo hipotálamo-hipófise-adrenal. A principal causa de IA entre adultos é o uso abusivo de glicocorticoides, medicamentos amplamente utilizados atualmente; já em crianças a Hiperplasia Adrenal Congênita (HAC) é a principal etiologia. É uma condição caracterizada por apresentação de sinais e sintomas muito inespecíficos, o que condiciona a necessidade de exames laboratoriais para a confirmação do diagnóstico. Seu tratamento inclui a reposição de glicocorticoides e de mineralocorticoides. Em situações de estresse, pode evoluir para crise adrenal, uma emergência médica que pode ser evitada com o diagnóstico precoce de IA e com a educação do paciente sobre sua doença e manejo. Sendo assim, ter conhecimento acerca dos conceitos da IA é essencial para ser levantada como uma hipótese e iniciar a investigação de forma mais rápida e não haver atraso no diagnóstico. Além disso, a indicação e o uso racional de glicocorticoides são umas das principais maneiras de prevenir o desenvolvimento da principal causa de IA nos dias de hoje.
ATUAÇÃO DO ENFERMEIRO NO CUIDADO AO PACIENTE DE TUBERCULOSE: REVISÃO DE LITERATURA
Authors: Coelho Elaine Cristina Dos Santos , Silva Nara Gomes Da
Published: January 2025

The National Program for Tuberculosis Control aims to promote, evaluate and carry out prevention, guaranteeing the treatment to the end. Nursing plays a fundamental role in promoting health, in prevention and early diagnosis and through health education that can make the person with tuberculosis aware of the disease and its treatment. It aims to gather and synthesize results of research related to tuberculosis and the role of nurses in the care of this patient. This is a descriptive study, with a qualitative approach such as bibliographic review. It was observed in the study the importance of nursing that plays a crucial role in tuberculosis control programs, being the protagonist in the prevention and control of tuberculosis, performing Or planning interventions in a comprehensive way.
TECNOLOGIAS, CIDADANIA E EDUCAÇÃO: PRÁTICAS DIGITAIS E RISCOS NO CONTEXTO DAS INSTITUIÇÕES ESCOLARES.
Authors: Macedo Abilio Jorge Cunha , Silva Junior Arnaldo Oliveira , Costa João Santos , Pereira Josemilson Garcia , Castro Jubenilson Santos , Amorim Juventina de Jesus R. , Pacheco Mirian Dias , Silva José Antonio da , Silva Shirley Macedo Silva e
Published: January 2025

This present work deals with technology as a necessary factor in educational and technological training for the construction of citizenship. The main objective of this work was to show that we currently live in a technological society characterized by interactivity. Thus, being able to perceive the important continuity in teacher and student training, citizenship and the necessary care in the use of technologies. In this way, one can see how technological advances have altered not only human relations, but also one of the most important sectors of a democratic and republican society, education. Technology has been used in the teaching-learning process as an aid to the student, to enrich the classes and fix the presented content. In this way, it can be considered that the continuous use of technological resources is a growing and current movement, taking into account the need of the education professional for constant training and/or updating. In the construction of this, bibliographic research was used, reading books, articles and several authors such as: (Kenski, 2003), (Lévy, 1999), (Pretto & Pinto, 2006), (Sêmola 2014).
Pengaruh Kompetensi dan Disiplin Kerja Terhadap Kinerja Karyawan PT PLN Enjiniring Jakarta
Authors: Ariyanti Rumodar Riza , Amas Lahat Mohammad
Published: January 2025

Penelitian ini bertujuan untuk mengetahui pengaruh kompetensi dan disiplin kerja terhadap kinerja karyawan pada PT. PLN Enjiniring Jakarta dengan menggunakan pendekatan kuantitatif, jumlah sampel yang digunakan dalam penelitian adalah 67 orang karyawan PT PLN Enjiniring Jakarta. Teknik pengumpulan data yang digunakan adalah teknik kuesioner. Teknik analisis data yang digunakan adalah regresi linear berganda, uji asumsi klasik, uji t, uji f dan koefisien determinasi. Berdasarkan hasil analisis menggunakan uji t dapat diketahui bahwa variabel independen yaitu kompetensi (X1) secara parsial berpengaruh secara positif dan signifikan terhadap variabel dependen (Y) yaitu kinerja karyawan, hasil pengujian variabel disiplin kerja (X2) menunjukkan secara parsial berpengaruh secara positif dan signifikan terhadap variabel dependen kinerja karyawan (Y). Kemudian hasil analisis menggunakan uji F dapat diketahui bahwa variabel independen kompetensi (X1) dan disiplin kerja (X2) secara bersama-sama berpengaruh signifikan terhadap variabel dependen yaitu kinerja karyawan (Y). Hasil analisis menggunakan koefisien determinasi diketahui bahwa 60,7% kinerja karyawan dipengaruhi oleh kompetensi dan disiplin kerja. Sedangkan sisanya 39,3% dipengaruhi oleh variabel lain yang tidak terdapat dalam penelitian ini.
 
This study aims to determine the effect of competence and work discipline  on employee performance at PT. PLN Enjiniring Jakarta by using a quantitative approach, The number of samples used in the study was 67 employees of PT PLN Enjiniring Jakarta. The data collection technique used is a questionnaire technique. The data analysis technique used is multiple linear regression, classical assumption test, t test, f test and the coefficient of determination. Based on the results of the analysis using the t test, it can be seen that the independent variable, namely competence (X1), partially has a positive and significant effect on the dependent variable (Y), namely employee performance. The results of testing the work discipline variable (X2) partially has a positive and significant effect on the dependent variable (Y), namely employee performance. Then the results of the analysis using the F test can be seen that the independent variables competence (X1) and work discipline (X2) together have a significant effect on the dependent variable, namely employee performance (Y). The results of the analysis using the coefficient of determination show that 60,7% of employee performance is influenced by competence and work discipline. While the remaining 39,3% is influenced by other variables not included in this study.
Pengaruh Kepemimpinan dan Pelatihan Terhadap Kinerja Pegawai Pada Direktorat Jenderal Pembinaan Pelatihan Vokasi dan Produktivitas Kementerian Ketenagakerjaan
Authors: Trinanda Putri Cindy , Soegeng Irwin Sukrisno
Published: January 2025

Kepemimpinan dan Pelatihan berperan penting dalam meningkatkan kinerja pegawai. Penelitian ini bertujuan untuk mengetahui pengaruh kepemimpinan dan pelatihan terhadap kinerja pegawai pada Direktorat Jenderal Pembinaan Pelatihan Vokasi dan Produktivitas Kementerian Ketenagakerjaan. Metode penelitian ini menggunakan metode kuantitatif. Populasi pada penelitian ini yaitu seluruh pegawai sebanyak 100 pegawai dan sampel penelitian sebanyak 80 orang yang ditentukan menggunakan rumus slovin. Analisis data menggunakan uji regresi linear berganda dengan bantuan SPSS 25. Hasil penelitian ini adalah (1) kepemimpinan tidak berpengaruh terhadap kinerja pegawai berdasarkan hasil uji T karena hasil t hitung -0,270 <  t tabel 1,991 serta nilai sig 0,788 > 0,05 (2) pelatihan berpengaruh terhadap kinerja pegawai berdasarkan hasil uji T karena hasil t hitung 6,608 > t tabel 1,991 serta nilai sig 0,000 < 0,05 (3) kepemimpinan dan pelatihan secara bersama-sama berpengaruh terhadap kinerja pegawai pada hasil uji F dimana nilai f hitung 53,529 > f tabel 3,11 dan nilai sig 0,000 < 0,05.
 
Leadership and Training play an important role in improving employee performance. This study aims to determine the influence of leadership and training on employee performance at the Directorate General of Vocational Training and Productivity Development of the Ministry of Manpower. This research method uses a quantitative method. The population in this study is all employees as many as 100 employees and the research sample is 80 people determined using the slovin formula. Data analysis using multiple linear regression test with the help of SPSS 25. The results of this study are (1) leadership has no effect on employee performance based on the results of the T test because the results of t count -0.270 < t table 1.991 and the sig value of 0.788 > 0.05 (2) training has an effect on employee performance based on the results of the T test because the results of t calculation 6.608 > t table 1.991 and the sig value of 0.000 < 0.05 (3) leadership and training together affect employee performance in the results of the F test where the f value is calculated 53.529 > f table 3.11 and the sig value is 0, 000 < 0.05.
Pengaruh Lingkungan Kerja dan Pemberian Reward terhadap Kinerja Karyawan pada PT Berkah Ibu Fashion Bekasi
Authors: Putri Alessia Zoraya , Sugeng Irwin Sukrisno
Published: January 2025

Lingkungan kerja dan pemberian reward memiliki peran dalam meningkatkan kinerja karyawan. Kedua faktor tersebut sangat penting untuk meningkatkan kinerja karyawan, namun masih terdapat keterbatasan dalam pemahaman tentang lingkungan kerja dan pemberian reward yang akan mempengaruhi kinerja karyawan pada PT Berkah Ibu Fashion. Penelitian ini bertujuan untuk melihat pengaruh lingkungan kerja dan pemberian reward terhadap kinerja karyawan pada PT Berkah Ibu Fashion. Penelitian ini menggunakan metode pendekatan kuantitatif dengan jenis asosiatif. Populasi dan sampel yang digunakan yaitu karyawan PT Berkah Ibu Fashion yang berjumlah 38 responden. Data yang diperoleh melalui penyebaran kuesioner diolah menggunakan program SPSS. Hasil penelitian menunjukkan bahwa tidak ada pengaruh secara signifikan dan positif dari lingkungan kerja terhadap kinerja karyawan pada PT Berkah Ibu Fashion dan adanya pengaruh signifikan dan positif dari pemberian reward terhadap kinerja karyawan pada PT Berkah Ibu Fashion. Lingkungan kerja dan pemberian reward berpengaruh signifikan dan positif secara simultan terhadap kinerja karyawan PT Berkah Ibu Fashion sebesar 20,9% dan sisanya sebesar 79,1% dipengaruhi variabel lain yang tidak terdapat dalam penelitian ini.
 
The work environment and rewards play a significant role in improving employee performance. Both factors are very important to improve employee performance. However, there is still a lack of understanding of how the work environment and rewards influence employee performance at PT Berkah Ibu Fashion. This research aims to examine the influence of the work environment and rewards on employee performance at PT Berkah Ibu Fashion. The research uses a quantitative approach with an associative design. The population and sample consist of 38 employees of PT Berkah Ibu Fashion. Data collected through questionnaires were analyzed using the SPSS program. The results indicate that the work environment does not have a significant positive influence on employee performance at PT Berkah Ibu Fashion, while rewards do have a significant positive influence on employee performance. The work environment and rewards simultaneously have a significant and positive effect on the performance of PT Berkah Ibu Fashion employees by 20.9% and the remaining 79.1% is influenced by other variables not included in this research.