bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Small Noncoding RNA in DNA Double-Strand Break Repair
Authors: Rzeszutek Iwona , Betlej Gabriela
Published: October 2020

DNA damage is a common phenomenon promoted through a variety of exogenous and endogenous factors. The DNA damage response (DDR) pathway involves a wide range of proteins, and as was indicated, small noncoding RNAs (sncRNAs). These are double-strand break-induced RNAs (diRNAs) and DNA damage response small RNA (DDRNA). Moreover, RNA binding proteins (RBPs) and RNA modifications have also been identified to modulate diRNA and DDRNA function in the DDR process. Several theories have been formulated regarding the synthesis and function of these sncRNAs during DNA repair; nevertheless, these pathways’ molecular details remain unclear. Here, we review the current knowledge regarding the mechanisms of diRNA and DDRNA biosynthesis and discuss the role of sncRNAs in maintaining genome stability.
Impact of Deoxycholic Acid on Oesophageal Adenocarcinoma Invasion: Effect on Matrix Metalloproteinases
Authors: Quilty Fran , Byrne Anne-Marie , Aird John , El Mashad Sheeren , Parra-Blanco Adolfo , Long Aideen , Gilmer John F , Medina Carlos
Published: October 2020

Bile acids (BAs) have been implicated in the development of oesophagitis, Barrett’s oesophagus and oesophageal adenocarcinoma (OAC). However, whether BAs promote cancer invasiveness has not been elucidated. We evaluated the role of BAs, in particular deoxycholic acid (DCA), in OAC invasion. Migration and invasiveness in untreated and BA-treated oesophageal SKGT-4 cancer cells were evaluated. Activity and expression of different matrix metalloproteinases (MMPs) were determined by zymography, ELISA, PCR and Western blot. Finally, human OAC tissues were stained for MMP-10 by immunohistochemistry. It was found that SKGT-4 cells incubated with low concentrations of DCA had a significant increase in invasion. In addition, MMP-10 mRNA and protein expression were also increased in the presence of DCA. MMP-10 was found to be highly expressed both in-vitro and in-vivo in neoplastic OAC cells relative to non-neoplastic squamous epithelial cells. Our results show that DCA promotes OAC invasion and MMP-10 overexpression. This study will advance our understanding of the pathophysiological mechanisms involved in human OAC and shows promise for the development of new therapeutic strategies.
Direct 3D Printing of Silica Doped Transparent Magnesium Aluminate Spinel Ceramics
Authors: Pappas John M. , Dong Xiangyang
Published: October 2020

Transparent magnesium aluminate spinel ceramics were additively manufactured via a laser direct deposition method in this study. With a minimum porosity of 0.3% achieved, highly transparent spinel samples with the highest total optical transmittance of 82% at a wavelength of 632.8 nm, were obtained by a 3D printing approach. However, cracking was found to be a major issue affecting printed spinel samples. To control prevalent cracking, the effect of silica dopants was investigated. Increased silica dopants reduced average total crack length by up to 79% and average crack density by up to 71%. However, a high dopant level limited optical transmission, attributed to increased porosity and formation of secondary phase. Further investigation found that with decreased average fracture toughness, from 2.4 MPa·m1/2 to 1.9 MPa·m1/2, the obvious reduction in crack formation after doping was related to decreased grain size and introduction of softer secondary phase during deposition. The study demonstrated the feasibility of the proposed laser direct deposition method in directly fabricating transparent spinel ceramics while dopants showed potentials in addressing cracking issues.
Dual-Mode Solution Plasma Processing for the Production of Chitosan/Ag Composites with the Antibacterial Effect
Authors: Titov Valerii , Nikitin Daniil , Naumova Irina , Losev Nikolay , Lipatova Irina , Kosterin Dmitry , Pleskunov Pavel , Perekrestov Roman , Sirotkin Nikolay , Khlyustova Anna , Agafonov Alexander , Choukourov Andrei
Published: October 2020

The development of novel biocompatible and biodegradable materials for medical applications has been drawing significant interest in the scientific community for years. Particularly, chitosan loaded with silver nanoparticles (Ag NPs) has a strong antimicrobial potential and could be applied, for example, as wound dressing material. In this work, chitosan/Ag NP composites were produced utilizing a single-step plasma-solution process, which is simple and environmentally friendly. An acetic solution of chitosan containing AgNO3 was treated by the direct current (DC) atmospheric pressure glow discharge, with the liquid serving as either cathode or anode. The plasma-solution system with liquid anode is more useful for the production of Ag NPs. Nevertheless, the NP size is comparable for both cases. The plasma treatment with both polarities led to chitosan degradation. The cleavage of glucosidic chains mostly occurred in the system with the liquid cathode, whereas the side oxidation reactions took place when the solution served as the anode. The oxidation processes were possibly induced by the hydrogen peroxide H2O2 efficiently formed in the last case. The composite materials produced with both polarities of liquid electrode demonstrated the bactericidal action against Gram-negative Escherichia coli, Gram-positive Staphylococcus aureus, and Gram-positive Bacillus subtilis.
The Scissors Effect in Action: The Fox-Flory Relationship between the Glass Transition Temperature of Crosslinked Poly(Methyl Methacrylate) and Mc in Nanophase Separated Poly(Methyl Methacrylate)-l-Polyisobutylene Conetworks
Authors: Pásztor Szabolcs , Becsei Bálint , Szarka Györgyi , Thomann Yi , Thomann Ralf , Mühlhaupt Rolf , Iván Béla
Published: October 2020

The glass transition temperature (Tg) is one of the most important properties of polymeric materials. In order to reveal whether the scissors effect, i.e., the Fox–Flory relationship between Tg and the average molecular weight between crosslinking points (Mc), reported only in one case for polymer conetworks so far, is more generally effective or valid only for a single case, a series of poly(methyl methacrylate)-l-polyisobutylene (PMMA-l-PIB) conetworks was prepared and investigated. Two Tgs were found for the conetworks by DSC. Fox–Flory type dependence between Tg and Mc of the PMMA component (Tg = Tg,∞ − K/Mc) was observed. The K constants for the PMMA homopolymer and for the PMMA in the conetworks were the same in the margin of error. AFM images indicated disordered bicontinuous, mutually nanoconfined morphology with average domain sizes of 5–20 nm, but the correlation between Tg and domain sizes was not found. These new results indicate that the macrocrosslinkers act like molecular scissors (scissors effect), and the Tg of PMMA depend exclusively on the Mc in the conetworks. Consequently, these findings mean that the scissors effect is presumably a general phenomenon in nanophase-separated polymer conetworks, and this finding could be utilized in designing, processing, and applications of these novel materials.
Magnesium Oxychloride Cement Composites Lightened with Granulated Scrap Tires and Expanded Glass
Authors: Pavlíková Milena , Pivák Adam , Záleská Martina , Jankovský Ondřej , Reiterman Pavel , Pavlík Zbyšek
Published: October 2020

In this paper, light burned magnesia dispersed in the magnesium chloride solution was used for the manufacturing of magnesium oxychloride cement-based composites which were lightened by granulated scrap tires and expanded glass. In a reference composite, silica sand was used only as filler. In the lightened materials, granulated shredded tires were used as 100%, 90%, 80%, and 70% silica sand volumetric replacement. The rest was compensated by the addition of expanded glass granules. The filling materials were characterized by particle size distribution, specific density, dry powder density, and thermal properties that were analyzed for both loose and compacted aggregates. For the hardened air-cured samples, macrostructural parameters, mechanical properties, and hygric and thermal parameters were investigated. Specific attention was paid to the penetration of water and water-damage, which were considered as crucial durability parameters. Therefore, the compressive strength of samples retained after immersion for 24 h in water was tested and the water resistance coefficient was assessed. The use of processed waste rubber and expanded glass granulate enabled the development of lightweight materials with sufficient mechanical strength and stiffness, low permeability for water, enhanced thermal insulation properties, and durability in contact with water. These properties make the produced composites an interesting alternative to Portland cement-based materials. Moreover, the use of low-carbon binder and waste tires can be considered as an eco-efficient added value of these products which could improve the environmental impact of the construction industry.
Suberitamides A–C, Aryl Alkaloids from a Pseudosuberites sp. Marine Sponge that Inhibit Cbl-b Ubiquitin Ligase Activity
Authors: Kim Chang-Kwon , Wang Dongdong , Wilson Brice A. P. , Saurí Josep , Voeller Donna , Lipkowitz Stanley , O’Keefe Barry R. , Gustafson Kirk R.
Published: October 2020

Three new aryl alkaloids named suberitamides A–C (1–3), were isolated from an extract of the marine sponge Pseudosuberites sp. collected along the coast of North Carolina. Their planar structures were established by extensive nuclear magnetic resonance (NMR) and mass spectrometry (MS) analysis. To assign the challenging relative configuration of the saturated five-membered ring in suberitamide A (1), a simple and efficient NMR protocol was applied that is based on the analysis of 2- and 3-bond 1H-13C spin-spin coupling constants using a PIP (pure in-phase) HSQMBC (heteronuclear single quantum multiple bond correlation) IPAP (in-phase and anti-phase) experiment. Suberitamides A (1) and B (2) inhibited Cbl-b, an E3 ubiquitin ligase that is an important modulator of immune cell function, with IC50 values of approximately 11 μM.
Immunostimulatory Effects of Polysaccharides from Spirulina platensis In Vivo and Vitro and Their Activation Mechanism on RAW246.7 Macrophages
Authors: Wu Xueyan , Liu Zhicong , Liu Yang , Yang Yu , Shi Fulin , Cheong Kit-Leong , Teng Bo
Published: October 2020

In this study, Spirulina platensis (S.p.) polysaccharide (PSP) was obtained by ultrasonic-microwave-assisted extraction (UMAE) and purified by an aqueous two-phase system (ATPS). Two different methods were applied to purified Spirulina platensis (S.p.) polysaccharide (PSP), respectively, due to PSP as a complex multi-component system. Three polysaccharide fractions (PSP-1, PSP-2, and PSP-3) with different acidic groups were obtained after PSP was fractionated by the diethyl aminoethyl (DEAE)-52 cellulose chromatography, and two polysaccharide fractions (PSP-L and PSP-H) with different molecular weight were obtained by ultrafiltration centrifugation. The chemoprotective effects of PSP in cyclophosphamide (Cy) treated mice were investigated. The results showed that PSP could significantly increase spleen and thymus index, peripheral white blood cells (PWBC), and peripheral blood lymphocytes (PBL). The in vivo immunostimulatory assays demonstrated that PSP could in dose-dependent increase of TNF-α, IL-10, and IFN-γ production in sera. The in vitro immunostimulatory assays showed that PSP and its fractions (PSPs) could evidently enhance the proliferation of splenocytes and RAW 264.7 cells and increase the productions of nitric oxide (NO), tumor necrosis factor-α (TNF-α), and interleukin 6 (IL-6). PSPs could also enhance phagocytic activity of RAW 264.7 cells. The acidic polysaccharide fractions of PSP-2, PSP-3, and PSP-L with small molecular weight had the higher immunostimulatory activity. Signaling pathway research results indicated that PSP-L activated RAW264.7 cells through MAPKs, NF-κB signaling pathways via TLR4 receptor.
Gut Feelings: How Microbiota Might Impact the Development and Course of Anorexia Nervosa
Authors: Seitz Jochen , Dahmen Brigitte , Keller Lara , Herpertz-Dahlmann Beate
Published: October 2020

Anorexia nervosa (AN) can probably be regarded as a “model” for studying the interaction of nutrition with the gut–brain axis, which has drawn increased attention from researchers and clinicians alike. The gut microbiota influences somatic effects, such as energy extraction from food and body weight gain, as well as appetite, gut permeability, inflammation and complex psychological behaviors, such as depression or anxiety, all of which play important roles in AN. As nutrition is one of the main factors that influence the gut microbiota, nutritional restriction and selective eating in AN are likely influencing factors; however, nutritional rehabilitation therapy is surprisingly understudied. Here, we review the general mechanisms of the interactions between nutrition, the gut microbiota and the host that may be relevant to AN, paying special attention to the gut–brain axis, and we present the first specific findings in patients with AN and corresponding animal models. In particular, nutritional interventions, including food selection, supplements, and pre-, pro- and synbiotics that have the potential to influence the gut microbiota, are important research targets to potentially support future AN therapy.
Overweight Women with Breast Cancer on Chemotherapy Have More Unfavorable Inflammatory and Oxidative Stress Profiles
Authors: L. D. Santos Letícia , D. D. Custódio Isis , Silva Alinne T. F. , C. C. Ferreira Izabella , C. Marinho Eduarda , C. Caixeta Douglas , V. Souza Adriele , R. Teixeira Renata , Araújo Thaise G. , Shivappa Nitin , R. Hébert James , Paiva Carlos Eduardo , S. Espíndola Foued , Goulart Luiz Ricardo , C. P. Maia Yara
Published: October 2020

Chronic inflammation and redox imbalance are strongly influenced by diet and nutritional status, and both are risk factors for tumor development. This prospective study aimed to explore the associations between inflammatory and antioxidant markers and nutritional status in women with breast cancer undergoing chemotherapy. The women were evaluated at three times: T0, after the infusion of the first cycle; T1, after infusion of the intermediate cycle; and T2, after the infusion of the last chemotherapy cycle. The consumption of antioxidant nutrients and the Total Dietary Antioxidant Capacity reduced between T0 and T2 and the Dietary Inflammatory Index scores increased throughout the chemotherapy. Blood samples taken at the end of the chemotherapy showed lower levels of glutathione reductase and reduced glutathione, with greater quantification of the transcripts for Interleukin-6 and Tumor Necrosis Factor α. It should be emphasized that the Total Dietary Antioxidant Capacity is lower and the Dietary Inflammatory Index is higher in the group of overweight patients at the end of the follow-up, besides showing lower levels of the redox status, especially the plasma levels of glutathione reductase (p = 0.039). In addition, trends towards higher transcriptional levels of cytokines in peripheral blood were observed more often in overweight women than in non-overweight women. In this study of 55 women with breast cancer, nine (16%) with metastases, diet became more pro-inflammatory with fewer antioxidants during the chemotherapy. Briefly, we have shown that chemotherapy is critical for high-risk overweight women due to their reduced intake of antioxidant nutrients, generating greater inflammatory and oxidative stress profiles, suggesting the adoption of healthier dietary practices by women with breast cancer throughout their chemotherapy.
Multiplexed tat-Targeting CRISPR-Cas9 Protects T Cells from Acute HIV-1 Infection with Inhibition of Viral Escape
Authors: Ophinni Youdiil , Miki Sayaka , Hayashi Yoshitake , Kameoka Masanori
Published: October 2020

HIV-1 cure strategy by means of proviral knock-out using CRISPR-Cas9 has been hampered by the emergence of viral resistance against the targeting guide RNA (gRNA). Here, we proposed multiple, concentrated gRNA attacks against HIV-1 regulatory genes to block viral escape. The T cell line were transduced with single and multiple gRNAs targeting HIV-1 tat and rev using lentiviral-based CRISPR-Cas9, followed by replicative HIV-1NL4-3 challenge in vitro. Viral p24 rebound was observed for almost all gRNAs, but multiplexing three tat-targeting gRNAs maintained p24 suppression and cell viability, indicating the inhibition of viral escape. Multiplexed tat gRNAs inhibited acute viral replication in the 2nd round of infection, abolished cell-associated transmission to unprotected T cells, and maintained protection through 45 days, post-infection (dpi) after a higher dose of HIV-1 infection. Finally, we describe here for the first time the assembly of all-in-one lentiviral vectors containing three and six gRNAs targeting tat and rev. A single-vector tat-targeting construct shows non-inferiority to the tat-targeting multi-vector in low-dose HIV-1 infection. We conclude that Cas9-induced, DNA repair-mediated mutations in tat are sufficiently deleterious and deplete HIV-1 fitness, and multiplexed disruption of tat further limits the possibility of an escape mutant arising, thus elevating the potential of CRISPR-Cas9 to achieve a long-term HIV-1 cure.
USING THE KANO MODEL TO BUILD A MANAGER APP PORTAL ACCOMMODATING THEIR USER PREFERENCES
Authors: Mayer Jorg H. , Esswein Markus , Quick Reiner , Sayar Sanjar
Published: October 2020

Nowadays, even apps for corporate management are respectable. Manager app portals complement such “run-a-business” apps with apps that make managers’ business life easier. The right mix of apps makes the difference. Accommodating the user perspective, the objective of this article is to examine which apps disproportionately influence managers’ perception regarding the usefulness of information systems (IS). Applying the Kano model and considering both “analyst-” and “consumer-type” managers, we employ findings from a manager focus group survey to discuss the strongest differentiators: (1) Offer collaboration bars and push notifications for analyst managers. Get consumer managers “online” with news tickers. (2) Make core reports more interactive with drill downs and filters for manager self-service. (3) Take “fun and enjoyment” into account when accommodating managers’ business life. (4) Consider that tablets create their own manager use case as a “first-stop information shop.”
Una aproximación de aplicación de la gestión del conocimiento en el Poder Judicial
Authors: Pacheco Huancas Iris Estela
Published: October 2020

La gestión del conocimiento constituye en los tiempos actuales una poderosa herramienta de cambio e innovación en cualquier tipo de organización, tanto privada como pública. En el presente artículo, la gestión del conocimiento plantea la creación, organización, renovación, transmisión y utilización del conocimiento adquirido durante años de impartición de justicia por magistrados y personal jurisdiccional del Poder Judicial, en función de sus necesidades específicas. La implementación de tecnologías de la información y la gestión del conocimiento en el ámbito judicial facilitaría y promovería el permanente aprendizaje dentro de la institución para lograr prontitud, certeza, predictibilidad en la solución de conflictos jurídicos.
El capital social en las diversas formas de la sociedad anónima, los principios y las diversas funciones que cumple tanto externa como internamente en estas
Authors: Walde Jáuregui Vicente Rodolfo
Published: October 2020

Dentro del sistema mercantil la sociedad anónima ocupa un lugar relevante, como se evidencia al realizar un análisis histórico de esta forma societaria; siendo merecedora de una especial regulación legal como contrato tipo de sociedad; alcanzando actualmente gran diversificación, influencia y desarrollo bajo diversas formas societarias. La sociedad anónima deviene así en una figura jurídica que reposa sobre el concepto de «capital» que constituye su esencia, término cuya comprensión parte de la distinción entre «patrimonio» y «capital social»; capital social que se encuentra regulado por el principio de Determinación y Unidad del Capital Social, y el principio de Estabilidad del Capital, los mismos que completan la defensa del capital de la sociedad por acciones, con los cuales se le pretende dar una protección adecuada a los negocios.
Autonomía privada y contrato
Authors: Leyva Saavedra José
Published: October 2020

Una de las instituciones que marca el paso del desarrollo del derecho privado no cabe duda de que es la ayer denominada autonomía de la voluntad y hoy mejor precisada autonomía privada; esto es, aquella libertad de los particulares, reconocida por los ordenamientos jurídicos, de regular sus propias relaciones jurídicas de la forma y manera querida por ellos. El derecho recorta, como bien se ha dicho, la superficie de la libertad existencial y devuelve, como recompensa, la libertad jurídica de las personas, organizada y precisada, para proyectar, perseguir sus propios objetivos, pero dentro de los límites señalados por cada ordenamiento. La indicada libertad está considerada dentro de los derechos fundamentales de las personas y encuentra su mejor plasmación en el contrato, posicionando en esta sede la autonomía contractual.

A pesar de su consideración de pieza maestra de las relaciones jurídicas privadas, la autonomía privada no tiene un espacio específico y explícito dentro de las Constituciones Políticas de los Estados, lo que realmente es preocupante, ya que se prefiere darle rango constitucional a una de las expresiones de tal autonomía, como es la libertad contractual.
Apuntaciones para la historia del derecho peruano. Un caso de política asistencial en favor de los partidos del corregimiento de Huaylas en el S. XVIII
Authors: Valverde Gonzáles Manuel Enrique
Published: October 2020

Se ofrece una retrospectiva histórica de los movimientos sociales indígenas surgidos en el siglo XVIII en el denominado Corregimiento de Huaylas, en el marco de las reformas introducidas en la estructura hacendaria por la administración colonial, destinadas a obtener mayor recaudación de caudales para la corona española, y de los excesos cometidos por la burocracia intermediaria encargada de la rigurosa recaudación de los tributos; hechos bajo cuyo contexto se analizan las repercuciones jurídicas del expediente promovido por los curacas de la doctrina de la provincia de Huaylas ante la administración política del virreinato del Perú, con el objeto de lograr el auxilio económico con los fondos de la Caja de Censos del Corregimiento, a fin de que se socorra a los indios de dicha provincia.
Extraordinary optical transmission and enhanced magneto-optical Faraday effects in one-dimensional metallic gratings
Authors: Lei Chengxin , Man Zhongsheng , Tang Shaolong
Published: October 2020

The optical and magneto-optical (MO) properties of two different magneto-optic-plasmonic structures including double-layer and single-layer metallic gratings have been investigated. Numerical simulations based on the extended finite difference time domain method have revealed that, in the two proposed structures, apart from the extraordinary optical transmission effect, there arises high MO Faraday rotation in a broad spectrum spanning visible to near-infrared frequencies. Despite the easy fabrication process, the double-layer grating structure still shows an enhancement in transmittance, Faraday rotation, and figure of merit by two, five, and two times, respectively, compared to the single-layer structure, and this can be further improved by suitably modifying the configuration. The physical mechanisms of the physical phenomena are explained in detail.
"Fragmentos de um noturno": interlocuções e história em Paulo Gaiad
Authors: Ruschel Nascimento Garcez Luciane
Published: October 2020

Fragmentos de um noturno (2008) é a obra analisada no artigo, partindo da premissa que o artista, nomeadamente artista visual, oferece nessa série a possibilidade de experienciarmos outras manifestações de artes, interlocuções matéricas e conceituais, a ver, a música e a composição musical, sendo o piano e a música erudita abordados por Gaiad como imagem, desdobramentos de sua própria experiência de vida. Percepções visuais de uma sonoridade que não nos alcança.
MANAGEMENT OF POSTERIOR REVERSIBLE ENCEPHALOPATHY SYNDROME IN AN UNBOOKED TERM PREGNANT CASE WITH ECLAMPSIA.
Authors: Aggarwal Sunny , dev Priyanka , Mazumder Sagar
Published: October 2020

Posterior reversible encephalopathy syndrome (PRES) usually presents with headache, confusion, visual disturbances or blindness and seizures. MRI is gold standard with parieto-occipital white matter changes due to vasogenic oedema in most of the cases. We report a 20-year-old unbooked primigravida with eclampsia prior to delivery which got complicated by PRES after delivery on day 1 postpartum. General anesthesia was given for caesarean section and post operatively patient was managed in ICU with strict blood pressure and seizure control. Clinical improvement with complete resolution without any complications was observed on the day 10 postpartum.
EFFICACY OF VAGINAL MISOPROSTOL IN FIRST AND SECOND TRIMESTER MISSED ABORTIONS
Authors: T Hema , R Annapoorani , M Karthiyayini
Published: October 2020

Objectives : Missed abortion is a common problem in obstetrics and gynecology. This study aims to study the efficacy of vaginal misoprostol in termination of first and second trimester missed abortions.
Materials and Methods: Fifty women with missed abortions were included in the study, out of which 30 patients were in first trimester comprised of group I, other 20 patients in second trimester were designated as group II. After getting informed consent, 200 mcg misoprostol was kept in posterior fornix, every 4 hours 200 mcg was repeated until the patient expelled. Parameters analyzed were induction abortion interval, change in PCV, success rate.
Results : In the present study out of the 70% (21/30) cases belonging to group I – the mean induction abortion interval was between 12-16 hrs. In group II category in (19/20) 95% of women , the mean induction abortion interval was less than 8 hrs. One patient failed to expel even after maximum of 4 dose and hence underwent surgical termination giving a failure rate of 5%, ‘P’ value is also significant.
Conclusion : Vaginal Prostoglandin E analogue (misoprostol) is a very safe and effective method to be used in missed abortion. It was more effective and successful in II trimester compared to I trimester. The failure rate was very minimum and complications were almost nil with very few side effects
Point Cloud Video Streaming: Challenges and Solutions
Authors: Liu Zhi , Li Qiyue , Chen Xianfu , Wu Celimuge , ishihara susumu , Li Jie , Ji Yusheng
Published: October 2020

Volumetric video (or hologram video), the medium for representing natural content in VR/AR/MR, is presumably

the next generation of video technology and a typical use case for 5G and beyond wireless communications. To realize volumetric video applications, efficient volumetric video streaming is in critical demand. This article responds to the challenges of and propose solutions to wireless transmission systems of point cloud video, which is the most popular and favored way to represent volumetric media and significantly differs from the other types of videos. In particular, we first introduce point cloud video technology and its applications, and then discuss the challenges of

and solutions to point cloud video streaming, including encoding, tiling, viewing angle prediction, decoding, quality assessment and transmission optimization. Furthermore, we explain a prototype of MPEG DASH-based point cloud video streaming system as a preliminary study, along with more simulation results to verify its performance. Finally, we identify future research directions for providing high-quality point cloud video streaming.
PELAYANAN PEMERIKSAAN KESEHATAN TELINGA HIDUNG TENGGOROKAN PADA ANAK SEKOLAH DASAR DI PEDESAAN
Authors: Limijadi Edward Kurnia Setiawan , Ningrum Farah Hendara , WSK Lydia Purnama , Lintang Sigid Kirana , KD Anna Mailasari
Published: October 2020

Kesehatan merupakan milik setiap manusia tak terkecuali anak-anak. Keadan sehat bagi anak-anak harus mendapatkan perhatian penuh untuk menunjang perkembangan individu. Keadaan sehat pada organ telinga, hidung, dan tenggorokan perlu diwujudkan sebagai salah satu upaya menuju Indonesia Sehat. Siswa SDN Gulon 2 merupakan siswa sekolah di pedesaan yang belum pernah memeriksakan kesehatannya, oleh karena itu diperlukan pemeriksaan telinga, hidung, dan tenggorokan. Pemeriksaan telinga, hidung dan tenggorokan dilakukan dengan bantuan senter dan spatula lidah untuk menilai bagian-bagian pada ketiga organ tersebut. Ditemukan kondisi telinga normal sebanyak 48,5% sedangkan sisanya terdapat serumen; kondisi hidung normal sebanyak 78,7%, sedangkan sisanya rhinitis akut; dan kondisi tenggorokan normal 66,7%, sedangkan sisanya tonsilitis kronis. Tatalaksana dilakukan terhadap telinga yang terdapat serumen apabila memungkinkan. Guru dan siswa sekolah dasar diberikan pendidikan kesehatan tentang kondisi telinga, hidung, dan tenggorokan berkaitan dengan pencegahan maupun tatalaksana selanjutnya apabila keadaan memberat. Kegiatan pengabdian masyarakat perlu dilakukan kepada siswa-siswa di sekolah dasar maupun tingkat lainnya terutama di pedesaan agar mereka memperoleh kesehatan yang optimal.
PEMBANGUNAN JALAN MAKAM RT. 01 RW.05 DESA KEDUNGLEPER KECAMATAN BANGSRI KABUPATEN JEPARA
Authors: Saputro Yayan Adi , Mahfidh Muhammad Khoirul
Published: October 2020

Community service activities by lecturers and students of the Civil Engineering study program, Faculty of Science and Technology, Islamic University of NahdlatulUlamaJepara at RT. 01 RW. 05 Kedungleper Village, Bangsri District is the construction of a concrete road (rigid pavement) to the tomb along 28 m, 3 m wide, and 0.12 m thick. Activities carried out include planning, implementation, monitoring and evaluation. The planning carried out by this community service team together with the village and community development team made drawings and RABs to be submitted to the village development planning deliberations. The implementation is carried out after approval of the proposal given by involving community assistance (community self-help) in 2 parts according to the day. On the first day there were 16 people doing self-help and on the second day there were 16 people. During the implementation process, the quality of work produced is carried out so that the results obtained are of good quality according to the plan.
Pendekatan Fenomenologi dalam Studi Islam
Authors: Sihabuddin Sihabuddin
Published: October 2020

Religion is the gift of God Almighty which is intended for humans (Muslims) as a guide to getsafety in the world and the hereafter, because in Islam there are rules that must be followed byindividuals and groups in order to distinguish between good (constructive-moralist) and which isbad (degradation-immoralis). Nevertheless, studying religion that collaborates science is notsomething that is prohibited. In fact, the correlation between religion and science is somethingthat is very likely to be carried by religious scholars, including in Islam. Understanding of theIslamic religion which has tended to be “theologically-normative” for decades has closed Islamicthinkers to study the phenomenon of Islam, such as understanding the practices of religiousteachings that tend to be ritualistic in each of the Muslims themselves. To understand it, aspecial method is needed called “phenomenology”, where this method describes the experienceof the religious practice of religious adherents consciously of the religious phenomena that arecarried out.
PENGARUH MODEL INKUIRI BERBANTUAN ALAT PERAGA EDUKATIF TERHADAP LITERASI SPASIAL
Authors: Yustitia Via
Published: October 2020

Spatial literacy is related to the ability to use mathematics related to geometry. Prospective elementary school teachers need to master spatial literacy. However, the spatial literacy of PGSD students is still unsatisfactory. One of the lecturers' efforts to improve the quality of learning. An inquiry-assisted inquiry model of educational props can be an alternative. The purpose of this study is to determine whether the inquiry model assisted by educational teaching aids influences spatial literacy. This research is a quasi-experimental study with the population of semester I PGSD students in 2019/2020. Through purposive sampling, researchers chose class D as the experimental class and class F as the control class. Data obtained through the test method. Data analysis uses a mean different test. The results showed that there was an influence of the inquiry model assisted by educational teaching aids on spatial literacy.
THE TEACHER AS A REFLECTIVE PRACTITIONER: A QUALITATIVE DESCRIPTIVE CASE STUDY OF TEACHING GRADE 4 IN A PROVINCE OF INDONESIA
Authors: Cendana Wiputra
Published: October 2020

The purpose of this classroom action research was to see the significance of self-reflection. This reflection is useful to improve teaching practice of having a character to affect students’ learning. This classroom action research took place in one of the private schools in Makassar, South Sulawesi province. The action research was done within a classroom that consists of 22 grade 4 students. The writer used three cycles to describe the progressive growth of both the writer and the students. For gathering data, the writer used several instruments such as documentation (lesson plans, feedback on lessons, and video recording), the writer’s reflection, students’ grade reports, students’ letters and a practicum portfolio. Through the use of the writer’s self-reflection during this practicum, the writer realized that self-reflection helps the writer to improve his way of thinking and acting in his teaching practice.

Keywords:Reflection, Teacher, classroom action research
PENGARUH METODE DEMONSTRASI DENGAN MEDIA KONKRIT TERHADAP PEMAHAMAN KONSEP GERAK BENDA
Authors: Arsih Rizka Janawati Mita , Santosa Agus Budi , William Nanda
Published: October 2020

Penelitian ini bertujuan untuk mengetahui seberapa pengaruh metode demonstrasi terhadap pemahaman konsep gerak benda pada pembelajaran IPA kelas IV SDN 3 Gandusari semester genap tahun pelajaran 2019/2020. Peneltian ini yang digunakan yaitu kuantitatif dengan jenis penelitian eksperimen. Populasi dalam penelitian ini seluruh siswa kelas IV dengan jumlah 10 siswa. Sedangkan sampel yang diambil pada penelitian ini 10 siswa. Metode pengumpulan data yang digunakan berupa tes. Tes yang digunakan untuk memperoleh data merupakan pretest dan posttest. Bentuk instrumen yang digunakan yaitu pilihan ganda dengan jumlah soal 20 item. Berdasarkan analisis yang telah diperoleh dari uji normalitas dengan menggunakan uji Shapiro-Wilk pretest signifikan sebesar 0,215>0,05. Jadi dapat disimpulkan bahwa hasil tersebut berdistribusi normal. Sedangkan untuk nilai posttest signifikan 0,311>0,05. Jadi dapat disimpulkan bahwa hasil tersebut berdistribusi normal. Sedangkan untuk hasil uji homogenitas diketahui nilai signifikansi Based on Mean 0,206 > 0,05. Sehingga dapat disimpulkan bahwa varian data pretest dan posttest adalah homogen (sama). Untuk pengujian hipotesis menggunakan uji paired sample test diperoleh nilai sig. (2-tailed) pretest dan posttest 0,000. Sesuai dengan uji pair sample t-test  bahwa nilai sig. (2-tailed) < 0,05 maka dapat disimpulkan bahwa terdapat perbedaan antara hasil belajar siswa pada data  pretest dan posttest. Dengan demikian hasil dari penelitian ini dapat disimpulkan bahwa terdapat pengaruh metode demonstrasi terhadap pemahaman konsep gerak benda pada pembelajaran IPA siswa kelas IV SDN 3 Gandusari semester genap tahun pelajaran 2019/2020.
DAYA SAING USAHA TANI PADI DI KECAMATAN SUSUKAN KABUPATEN SEMARANG MENGGUNAKAN METODE PAM (POLICY ANALYSIS MATRIX)
Authors: Nargy Justra Septaris Yoanes Krisostomos , Prihtanti Tinjung Mary
Published: October 2020

Competitiveness requires a country to excel in competitive and comparative advantage. The commodities that need to be developed are rice. This commodity was chosen because it is a commodity that the government prioritizes and is full of agricultural policies. The purpose of this study is to determine profits, competitive and comparative advantages and the impact of government policies. This research was conducted in March 2018 in Susukan District, Semarang Regency. The sampling technique used purposive sampling technique with a total of 30 respondents. Data analysis using Policy Analysis Matrix (PAM). The results showed that farming has a competitive and comparative advantage seen from the value of PCR and DRCR less than 1 but the DRCR value of 0.935 means that farming is feared no longer has comparative advantage if there is no interference from government policy. For the government, the policy of subsidizing fertilizers and pesticides is continued so that the farming business remains competitive but the use of fertilizer by farmers should be reduced so that it is in accordance with recommendations from the Agriculture Service or researchers. Marketers should target the domestic market because the price of rice in the international market is lower than in the country.
The extention rank ordering criteria weighting methods in fuzzy enviroment
Authors: Roszkowska Ewa
Published: October 2020

Weight elicitation is an important part of multi-criteria decision analysis. In real-life decision-making problems precise information is seldom available, and providing weights is often cognitively demanding as well as very time- and effort-consuming. The judgment of decision-makers (DMs) de-pends on their knowledge, skills, experience, personality, and available information. One of the weights determination approaches is ranking the criteria and converting the resulting ranking into numerical values. The best known and most widely used are rank sum, rank reciprocal and centroid weights techniques. The goal of this paper is to extend rank ordering criteria weighting methods for imprecise data, especially fuzzy data. Since human judgments, including preferences, are often vague and cannot be expressed by exact numerical values, the application of fuzzy concepts in elicitation weights is deemed relevant. The methods built on the ideas of rank order techniques take into account imprecise information about rank. The fuzzy rank sum, fuzzy rank reciprocal, and fuzzy centroid weights techniques are proposed. The weights obtained for each criterion are triangular fuzzy numbers. The proposed fuzzy rank ordering criteria weighting methods can be easily implemented into decision support systems. Numerical examples are provided to illustrate the practicality and validity of the proposed methods.
Modeling of business processes of the commercial enterprise
Authors: POSHYVALOVA Olena
Published: October 2020

The work considers the peculiarities of formulating the business model of the commercial enterprise on the basis of improvements in the accounting and analytical support. A particular role of the rational organization of accounting in the implementation of principles of re-engineering in the enterprise business processes has been proven within the scope of the presented paper. For these purposes, the accounting ratios and indicators represented in the reporting information must remain precise, reliable and relevant, adapted to transfer and identification by all hardware resources and technological means without data corruption. The paper incorporates the elaborated scheme for re-engineering of accounting and analytical support for inventory management according to the intended purposes. It is determined that forecasting of the prospects of the enterprise development based upon conducting re-engineering of the accounting and analytical system serves to establish the best possible directions for its activity, to evaluate new possibilities and alternatives that are employed in drafting the balance statements in the process of predictive assessment and promotes the rational use of resources. The re-engineering is based upon the use of the latest information technologies. Therefore, quite frequently re-engineering becomes compared to the notions of computerization of business processes, automation and reorganization of the enterprise. The processes must be conceived with the use of modern communication technologies, use of the Internet, objective multi-level models for development of computing systems, achievements in the domain of databases. Information technologies are intended to facilitate the management of large amounts of data. Implementation of the principles of re-engineering within the practical activity of enterprises requires continuous stimulation of the personnel towards their professional growth. Introduction of the computer-mediated system of accounting at the enterprise must be preceded by the re-engineering of business processes, i.e. re-thinking and re-designing the enterprise activities for the purpose of achieving sizeable improvements in such key indicators of modern business management as the profit, the quality, the level of service and the prompt responsiveness. The success of re-engineering is bound with fast transformations in the enterprise while namely the radical nature of measures applied serves as the key indicator. It is imperative that enterprise employees would be committed to radical and swift changes in their work, with the corresponding absence of conflicts. Another point of success would be managing every employee of the company to form a common and specific understanding of the future of enterprise.
Strategic orientations of agricultural enterprises in the context of sustainable development
Authors: POLENKOVA Maryna
Published: October 2020

The article describes the concept of sustainable development. Peculiarities of enterprise functioning in the context of sustainable development are outlined. It is substantiated that sustainable development requires the integration of economic, social and environmental goals of enterprises, as well as adaptation to system requirements. Strategic guidelines of agricultural enterprises in the context of sustainable development are proposed, covering key areas of socio-economic life of rural areas.
Business people associate sustainable development primarily with economic growth and decent work. Natural resource or welfare goals are considered less important by many companies, so most companies do not try to integrate corporate governance, business strategies and reporting forms into sustainable development. However, globally, companies have realized that business sustainability is becoming a competitive advantage, with both investors and consumers demanding more responsibility. Despite a good awareness of this issue, progress in achieving the goals of sustainable development can be destabilized by the lack of specific objectives, evaluation methods and expanded business integration.
On the one hand, the development of rural areas depends on the available resources, technologies, the existing institutional environment, as well as on the competitiveness of local goods and services. On the other hand, sustainable development requires the preservation of local economic, social and environmental assets for the future. A comprehensive approach is needed to address these trade-offs.
The strategy of sustainable development of the enterprise is accompanied by a certain mechanism that triggers the irreversible process of its positive transformation. A well-designed sustainable development strategy, in addition to the obvious benefits to society and the environment, will help companies attract investors and customers and, in some cases, receive financial support.
The Optimalization of Zakat in Achieving Maqashid Sharia
Authors: Kurnia Zahra Nabila , Mustafida Rifka , Fauziah Najim Nur , Subri Nur Shazni , Ahmad Faiz Farihah Amirah
Published: October 2020

Zakat is one of the instruments for well-being distribution. Zakat is also one of the most significant institution of Islam, in early Islamic zakat proved to be an extremely effective tool for poverty alleviation and inclusive finance. Total potential of zakat in the OIC member countries ranges from 1.8 percent to 4.34 percent of their GDP. Zakat has the potential to be developed economically. In contrary, development and performance of zakat institutions was relatively poor and this is illustrated by the collection of zakat in Muslim countries on average very low, less than 1% of GDP.

Maqashid Syariah is considered intellectual methodologies for Islamic studies and Non-Law studies. This has been used by the Muslim scholars to propose Islamic reform and revival in many aspects of live and to address problems of the Ummah in a way that is in line with Islamic tradition and aspirations. The institutions could make the Maqashid Sharia as an essential benchmark to design zakat distribution programs in both countries.

Zakat Institution objective should be the leading institution in economic empowerment of society by enacted Maqashid Sharia as the basis of designing the sustainable empowerment indicators. This paper aims to analyze and evaluate institutional program of collecting zakat in reaching Maqashid sharia and to identify the issues and the strategies of Zakat institutions. This study presents a comparison of zakat distribution programs between two countries, Indonesia and Malaysia, represented by Bazis DKI Jakarta and LZS in achieving five Maqashid Sharia aspects. This paper contributes to sustain the social life development in terms of the proper Zakat distribution by considering Maqashid Sharia. The originality of this paper is to provide provide insight for strategy on how Zakat institution could optimize their potency in achieving Maqashid Sharia.
Про одностайно неперервні сім’ї відображень метричних просторів
Authors: Sevost'yanov E. A. , Skvortsov S. O. , Petrov E. A.
Published: October 2020

УДК 517.5
Отримано аналоги результатів про одностайну неперервність сімей квазірегулярних відображень, які не набувають значень з деякого континуума. Доведено, що вказані сім'ї є одностайно неперервними,якщо характеристика квазіконформності відображень має скінченне середнє коливання в кожній внутрішній точці. Окремо досліджено випадок узагальнених квазіізометрій ріманових многовидів.
A Search for FeH in Hot-Jupiter Atmospheres with High-dispersion Spectroscopy
Authors: Kesseli Aurora Y. , Snellen I. A. G. , Alonso-Floriano F. J. , Mollière P. , Serindag D. B.
Published: October 2020

Most of the molecules detected thus far in exoplanet atmospheres, such as water and CO, are present for a large range of pressures and temperatures. In contrast, metal hydrides exist in much more specific regimes of parameter space, and so can be used as probes of atmospheric conditions. Iron hydride (FeH) is a dominant source of opacity in low-mass stars and brown dwarfs, and evidence for its existence in exoplanets has recently been observed at low resolution. We performed a systematic search of archival CARMENES near-infrared data for signatures of FeH during transits of 12 exoplanets. These planets span a large range of equilibrium temperatures (600

4000 K) and surface gravities (2.5

3.5). We did not find a statistically significant FeH signal in any of the atmospheres, but obtained potential low-confidence signals (signal-to-noise ratio ∼ 3) in two planets, WASP-33b and MASCARA-2b. Previous modeling of exoplanet atmospheres indicate that the highest volume mixing ratios (VMRs) of 10−7 to 10−9 are expected for temperatures between 1800 and 3000 K and log

. The two planets for which we find low-confidence signals are in the regime where strong FeH absorption is expected. We performed injection and recovery tests for each planet and determined that FeH would be detected in every planet for VMRs

, and could be detected in some planets for VMRs as low as

. Additional observations are necessary to conclusively detect FeH and assess its role in the temperature structures of hot-Jupiter atmospheres.