bluuebunny/crossref_metadata_2025 huggingface dataset:
THE PROVING OF THE CATHOLIC DOCTRINE OF THE PRIMACY OF THE POPE BY THE UKRAINIAN POLEMICIST THEODORE SKUMYNOVYCH
Authors:   Shevchenko Institute of Literature, National Academy of Sciences of Ukraine, Tkachuk Ruslan
Published: August 2023

The article reveals the arguments of the primacy of the Pope in the universal church given by the Ukrainian Catholic polemicist Theodore Skumynovych in the work "Przyczyny porzucenia Disuniey przezacnemu narodowi ruskiemu podane" (1643). Justifying the supremacy of the Roman cathedra, the writer gave an "argument from history" that Pope Sylvester I, having elevated the bishop of Byzantium Mitrophan to the patriarchal title, founded the Patriarchate of Constantinople. In the context of the history of the Byzantine Church, the Catholic writer raised the question of the legality of the Patriarchs of Constantinople use of the title "oecumenicus episcopus", which the bishops of the Eastern Churches called Pope Leo I at the Council of Chalcedon (451). It is revealed the details of the dispute between Pope Gregory the Great and Patriarch John IV the Faster concerning the naming of the Patriarch of Constantinople as an "oecumenicus episcopus". Theodore Skumynovych considered the historical facts of the appointment and displacement of the first hierarchs of the East to be proof of the judicial supremacy of Rome. In particular, the polemicist talked about the restoration of Athanasius the Great and Paul I in the episcopal cathedra by Pope Julius I. From the "Poluustav" of the Vilnius Holy Spirit Monastery the writer cited the story of the appointment of St. Hippolytus of Rome by the Pope as bishop of Portuen. Proving the primacy of the Roman Church, Theodore Skuminovych relied on the facts of the anathematization of the Byzantine emperors and first hierarchs by the bishops of Rome. The most persuasive example of this was the story of the exile of John Chrysostom from the Constantinople's cathedra. The article provides some details of the episcopal ministry of John Chrysostom, such as: the gist of church reforms, relations with the imperial court and Theophilus of Alexandria and also the appeal to Pope Innocent I. The focus of Theodore Skuminovich's attention is the anathema pronounced by Pope Innocent I against Emperor Arcadius, Eudoxia and the dead at that time Patriarch Arsakiy. The return by Pope Nicholas I to the patriarchal cathedra in Constantinople of Patriach Ignatius served to the polemicist as an argument in favor of the primacy of the Pope. In the story about the displacement of Patriarch Photius, the writer mentioned the Fourth Council of Constantinople (869), which in the Catholic Church is considered the Eighth Ecumenical Council. The Other proofs of the supremacy of the Pope were the information from the lives of Maxim the Confessor, Stephen the New and Theodorit the Studite.
TRANSLATION OF "APOPHTHEGMS" OF ANACHARSIS OF SCYTHIA
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Turenko Vitalii
Published: August 2023

For the first time, the translation (from ancient Greek and Latin) into Ukrainian of the entire body of reasoning and fragments available today, which are attributed to the outstanding early Greek philosopher Anacharsis of Scythia (VIII-VI centuries BC), is presented. It was found that the majority of apophthegms are built according to the principle of antithesis: in order for a thought to arise, the thinker needs to move away from the opponent's thought, and then refute it. It was established that this pre-Socratic paid little attention to the classical problem of the philosophical searches of pre-classical ancient Greek thinkers – ontology (cosmology), while ethical-anthropological and socio-political topics played an important role for him.
Seismic Site Characterization in the Charlevoix Region, Québec
Authors: Molnar Sheri , Foulon Thomas , Sharma Hema , Ross Martin , Parent Michel
Published: August 2023

Significant earthquake site effect potential exists in Charlevoix, Québec, the most seismically active region in the eastern Canada. Most of the population there lives on two buried river valleys (Du Gouffre in the west and Malbaie in the east) filled by ≤350 m of glacial, glaciomarine, and fluvial deposits atop hard rock. To constrain seismic site conditions and material properties in the two buried river valleys, we performed 164 single-station microtremor measurements and passive- and active-source seismic array testing at six sites. Joint inversion of fundamental-mode Rayleigh-wave dispersion and microtremor horizontal-to-vertical spectral ratio (MHVSR) datasets was performed to obtain shear-wave velocity (VS) depth (z) profiles at the six array sites. The 164 calculated MHVSRs are used to obtain a spatial distribution of the MHVSR fundamental frequency (f0HV) within, and to define the boundaries of, the buried river valleys. The Du Gouffre River valley is marked by low f0HV (0.44–1 Hz), with f0HV increasing progressively from the valley center to its edges and decreasing southward toward the river mouth. The Malbaie River valley is marked by higher f0HV (1–2 Hz), with several areas of higher f0HV within the valley, indicating a shallower sediment depth. The inverted VS(z) profiles demonstrate that sediments are thickest (∼150 m) under Baie Saint-Paul at the mouth of the Du Gouffre River and thin to <50 m headward as well as in the neighboring Malbaie valley. We compile our inverted VS(z) with other available VS(z) data in Charlevoix to derive a linear average VS–z relationship of Charlevoix soils. Soils in Charlevoix have an intermediate VS–z relationship between that of low VS soils in Ottawa–Gatineau and high VS soils in Montreal and Québec City. At greater depths, Charlevoix’s VS–z relationship is most similar to clays in nearby Saguenay, Québec.
Chronic Sexual Intoxication as a Manifestation of the Crisis of the West. Thoughts of Twentieth-Century Cultural Traditionalists
Authors:   Adam Mickiewicz University, Poznań, Jedliński Marek
Published: August 2023

The aim of this article is to discuss the views of cultural traditionalists on human sexuality. The paper presents the views of the following thinkers: René Guénon, Julius Evola, and Pitirim Sorokin. Each represents a different line of cultural traditionalism. However, they are united by expressive, radical views as well as by peculiar choices and life experiences. (Guénon was a convert to Islam, Evola sympathized with paganism and fascism, whereas Sorokin was one of the fathers of American sociology, an emigrant from Russia, with the soul of a “Russian traditionalist.”) René Guénon, Julius Evola, and Pitirim Sorokin recognized a deep crisis of the Western world. They argued that the cause of this crisis was sexual intoxication: anarchy and the sexual revolution. They thought that culture and the spiritual tradition in the Western (material) civilization was disappearing and that the primary cause of the crisis and the decline of the West were individualism and rationalism – manifesting themselves as pride, prudishness, perversion, the cult of the body, and orgasm. Guénon, Evola and Sorokin craved the restoration of the previous state: the sacralization of sex, community bonds, male domination, and ritual procreation. This was supposed to prevent the crisis and the decline of culture.
The Information Crisis and Silence in Philosophical-Cultural Perspective
Authors:   Lublin University of Technology, Faculty of Fundamentals of Technology, Department of Teaching Methods and Techniques Poland, Rarot Halina , Wójcik Tomasz ,   graduate of the John Paul II Catholic University of Lublin, Faculty of Humanities Poland
Published: August 2023

Among various forms of contemporary socio-cultural crises, one of the most challenging is the information crisis, which arises as a consequence of the dominance of postmodern information civilization. Often viewed through a pessimistic lens, the information crisis is understood as the excessive production of textual, visual, and auditory information in both public sphere and high culture. This surplus of information leads to its devaluation and has unforeseen and significant consequences. From this catastrophic perspective, there seems to be no escape from this overwhelming abundance of information. However, this article aims to provide a broader and more realistic understanding of the information crisis. To achieve this comprehensive perspective, the article draws upon research findings from various fields within the humanities and social sciences, such as cognitive psychology, psychology of human development, psychology of crisis and crisis intervention, and sociology of culture. By incorporating these interdisciplinary insights, the article culminates in a philosophical and cultural synthesis. Additionally, the article explores remedial strategies proposed by Tomasz Szlendak (a cultural sociologist) to counter the negative effects of information overload, with particular emphasis the value of silence.
Comparison of Non-viral Delivery Vehicles for CRISPR/Cas9 Therapies
Authors: Henry Deborah
Published: August 2023

CRISPR/Cas9 is a gene editing tool that is rapidly replacing previous technologies, such as ZFNs and TALENS, to rectify disease-causing mutations. Oftentimes, these diseases have treatment methods that target the symptoms rather than the cause. Recent innovations in bioengineering suggest that novel gene therapies may provide a better alternative than existing treatments, by correcting the cause of the disorder directly: the genomic DNA. The excitement around gene therapy, however, is abated by the challenges in how to deliver the technology. Currently, there are two methods of delivery, viral and non-viral vectors, of which non-viral vectors are considered safer and more practical. Such non-viral carriers include gold nanoparticles, lipid nanoparticles, and polymeric carriers, of which will be the focus of this paper. This review examines the efficacy of these existing non-viral carriers through a comprehensive literature analysis. We compare the percentage of cells showing the targeted change in vivo and in vitro across the different vehicles in an attempt to understand how efficacy changes across vectors. Overall, we highlight that the optimal delivery platform is likely dependent on the disease model and target tissue. In the future, researchers can use this analysis to assess currently available designs and develop new carriers for transporting CRISPR/Cas9 to specific targets in vivo and in vitro.
Impact of Lean Tools in the Supply Chain: Pharmaceutical Industry Perspective
Authors:   the Facultad de Ingeniería y Arquitectura, Universidad de Lima, Peru, Aguirre-Manrique Sebastián , Wong-Lam Valeria , Chávez-Ugaz Rafael
Published: August 2023

The aim of this paper is to identify the impact of the application of lean tools in the pharmaceutical supply chain (PSC) through a literature review. Supply chain inefficiencies before and during the COVID 19 pandemic, most applied tools, and lean improvements found in the PSC are identified. Databases such as Scopus and Proquest were used to collect the peer-reviewed articles to be studied. Results show the most frequent inefficiencies in the supply chain are found in operating costs, scrap rates, delivery times, and drug shortages. The improvements identified can be summarized in three factors: cost reduction, time reduction, and improvement in the management of activities. The most studied tools are Kaizen, Kanban, Total Quality Management (TQM), and Value Stream Mapping (VSM). Literature reveals that lean tools have a significant impact on quality improvement of information, products and/or services, as well as on the reduction or elimination of activities that do not generate value; in addition, there is little evidence of reduction of unnecessary movements of workers. The value of this paper addresses the impact of the pandemic on PSC, describing the versatility that each of the tools had in their role to reduce lean wastes. The versatility allows to identify which tool may be available according to the need of the practitioner.
Middle East Refugee Crisis in Europe and Turkey : A Systematic Literature Review
Authors: Felicia Nabila Putri  , Salahuddin  , Syamsul Rizal  , Gonda Yumitro
Published: August 2023

This study aims to discuss how the European Union and Turkey deal with the Syrian refugee crisis. The research method used in this study was a systematic literature review using 504 scientific articles sourced from the Scopus database. In reviewing the articles, the authors used the Vosviewer application. The results revealed that Syrian refugees were accommodated correctly and facilitated properly and contributed to the problem by providing insight into digital literacy, information needs, and strategies among Syrian and Iraqi refugees entering Europe and changing perspectives on migrants and refugees as passive victims of this event made to make Syrian refugee decisions to stay in Germany, in an econometric strategy based on estimating models of equality in social unity, economic integration and the decision to stay. The results contribute to developing a research roadmap on the Syrian internecine crisis in Turkey and the European Union and contribute to international relations science. Turkey and the European Union. Subsequent research must use scientific articles from other reputable international databases, such as Web of Science and Dimensions Scholars.
Grain Corridor Agreement and Turkey’s Role in the Russia-Ukraine War
Authors: Ay Hakkı M. , Söylemez Adnan
Published: August 2023

On the morning of February 24, 2022, when the Russian military entered Ukraine and launched air and missile raids on the targets it detected in the depths of this country, a war started in the east of Europe. As a result of the war between two of the world’s largest grain producers, a global grain crisis is taking place. Turkey has long sought to emphasize connectivity and strengthen its strategic position at the intercontinental crossroads between Europe and Asia. Functionally, Turkey serves as a vital transit corridor for key resources such as energy and food supplies, which becomes even more important given the economic and trade disruptions of Russia’s war in Ukraine. This study analyzed Turkey’s diplomatic efforts and policies during the war and the food deal process.
The Influence of Social Media Marketing on Patient Visit Intention Mediated by Brand Awareness
Authors: Hariyanti Tita , Kurniawan Gladys , Yunus Achmad , Saputro Dwi , Husada Unix Cahya , Rhynanti Catharina Louise , Rohman Fatchur
Published: August 2023

Social media marketing can increase consumer awareness and recognition of a brand (brand awareness) from a product or service. Brand awareness can ultimately influence the formation of consumer visit intentions for these products and services. RSU Universitas Muhammadiyah Malang (RSU UMM) is one of the Type C general hospitals conducting social media marketing since 2018. This study aims to determine the effect of social media marketing on the visit intention of patients at the hospital. The research was conducted with a quantitative observational method in a cross-sectional study using a questionnaire through Google Forms. The research sample was 96 people who were loyal consumers (followers) of the social media accounts (Facebook, Instagram, and Twitter) of the RSU UMM. Data analysis was carried out by using Partial Least Square (PLS). The findings showed a positive and significant influence of social media marketing on the patient's visit intention, mediated by the patient's brand awareness. This research concluded that RSU UMM's social media marketing efforts positively and significantly affected patient visit intentions and strengthened by the influence of brand awareness. Therefore, RSU UMM must improve its marketing strategy, primarily through social media marketing.
Analysis of Medical Costs of Type 2 Diabetes Mellitus Outpatient Muhammadiyah Hospital North Sumatra
Authors: Royyan Ashri  , Destanul Aulia  , Siregar Fazidah Aguslina
Published: August 2023

Type 2 diabetes mellitus and its complications are expensive. Complications are major cost drivers. Of the ten most outpatient diagnoses at Muhammadiyah Hospital, North Sumatra, there was a negative difference between INA-CBGs rates and hospital rates for type 2 diabetes mellitus cases. This study aims to estimate the medical cost, assess the average cost difference, and examine the cost component associated with outpatient type 2 diabetes mellitus. This quantitative analytic research used secondary data on outpatient medical records of type 2 diabetes mellitus patients from May 2019-April 2020. There were 61 samples of medical records. Results showed that the average annual medical cost of outpatient type 2 diabetes mellitus without complication was IDR. 298,177, 8 and IDR. 853,696,7, IDR. 932,341,7, IDR. 938,433.3 if accompanied by macrovascular complications, microvascular complications, and both, respectively. There was a significant difference (p = 0.004) in the mean medical costs per year between the complication groups. Drug costs significantly differed (p = 0.010) between the complication groups. Drug costs are the most expensive and are strongly associated with the medical costs of complicated type 2 diabetes mellitus.
Indonesia-Singapore Strategy Cooperation Diplomacy in the COVID-19 Pandemic in Batam City
Authors: Putri Rizqi Apriani , Pratama Dhany Putra , Mahadiansar Mahadiansar , Swastiwi Anastasia Wiwik
Published: August 2023

This study aims to determine the strategy of diplomatic cooperation between Indonesia and Singapore and have bilateral relations between Indonesia and Singapore and for researchers to understand and analyze the cooperation strategies the two countries have carried out during the COVID-19 pandemic. The method used by the author in this study was qualitative and would answer a more comprehensive phenomenon. This method was sourced from literature studies, written documents, online searches, and other relevant supporting documents that will be used as secondary data collection techniques. Cooperation between Indonesia and Singapore has been established since 1967. The COVID-19 pandemic has had an impact on both countries. Singapore, which is directly adjacent to Batam City, one of the regions in the Riau Islands, Indonesia, was affected by the COVID-19 pandemic. Almost all countries carried out various policies limiting mobility from tourists to trade. This pandemic provided new opportunities for Singapore-Indonesia, especially in Batam City, by creating a new collaboration. The strategy to increase cooperation between the two countries in tourism to investment and development is called “Three Bridges,” which consists of travel bubble bridges, infrastructure bridges, and digital bridges. The “Three Bridges” development strategy, to increase cooperation when COVID-19 hit the situation between the two countries, is a multidimensional program in the future. Singapore and Batam City have proximity in the border area of various sectors of cooperation. Thus, this pandemic can increase diplomatic cooperation between Indonesia and Singapore, which is a country that is directly adjacent and assisted by stakeholders between the two countries.
Analisis Bibliometrik Pelayanan Publik untuk Penyandang Disabilitas
Authors: Salsabiila Marsaa , Yuadi Imam
Published: August 2023

Pelayanan publik untuk penyandang disabilitas saat ini masih menjadi topik pembahasan yang perlu banyak dikaji. Masih banyak pelayanan publik yang tidak ramah akses untuk para penyandang disabilitas.  Pelayanan publik yang tidak merata untuk para penyandang disabilitas yang dimana jumlah penyandang disabilitas tergolong cukup banyak menimbulkan adanya rasa iri atas ketimpangan yang diberikan oleh pemerintah kepada masyarakat. Tujuan penelitian ini adalah mengetahui perkembangan riset dalam melihat perkembangan pelayanan publik untuk penyandang disabilitas.  Metode penelitian menggunakan analisis bibliometrik dalam memberikan gambaran terkait sebaran publikasi studi pada bidang pelayanan publik terkhususnya pelayanan publik untuk penyandang disabilitas. Analisis bibliometrik ini menerapkan limit dalam penentuan data yang akan digunakan dalam penelitian dengan melihat pertumbuhan penelitian terkait pelayanan publik untuk penyandang disabilitas. Hasil dari penerapan limit kemudian di export dalam format RIS dan BibTex. Format RIS digunakan pada visualisasi menggunakan bantuan aplikasi VOSviewer. Sedangkan format BibTex digunakan pada visualisasi menggunakan  bantuan aplikasi Biblioshiny. Hasil akhir analisis bibliometrik ini adalah memvisualisasi jurnal dan penulis yang relevan dengan topik bahasan dan analyze result yang menghasilkan visualisasi dari bidang kategori yang relevan, jenis dokumen, afiliasi yang turut berkontribusi, persebaran wilayah, dan tingkat publikasi setiap tahun dari data 145 data dokumen. Visualisasi yang dihasilkan dari analisis bibliometrik ini selain dapat mempermudah memperoleh data dan memahami aspek-aspek pendukung dalam pembahasan pelayanan publik untuk penyandang disabilitas. Dapat juga memahami ada beberapa aspek yang kurang diteliti dalam adanya pelayanan publik untuk disabilitas.
La adecuada reinserción social del recluso como finalidad de la ejecución penitenciaria en el estado social y democrático de derecho en Argentina
Authors: Arocena Gustavo Alberto
Published: August 2023

En el presente artículo, el autor analiza la adecuada reinserción social del recluso como finalidad de la ejecución de la pena privativa de la libertad en el Estado social y democrático de Derecho de la República Argentina. Con ese propósito, el jurista identifica los diferentes modelos dereadaptación social (“readaptación para la moralidad” y “readaptación para la legalidad”), con sus virtudes y críticas. Por último, él examina los condicionamientos que impone un arquetipo de Estado social y democrático de Derecho, a la hora de adherir a uno u otro de esos modelos, y, finalmente, expone sus razones a favor de un paradigma de readaptación social mínimo.
El joven Nietzsche y la verdad en la enseñanza del Derecho: una aproximación
Authors: Arancibia Camilo
Published: August 2023

Uno de los campos donde el Derecho y Literatura se ha hecho fuerte es en la Enseñanza del Derecho. Las palabras de la ley, aquellas que aprenden nuestros estudiantes desde la dogmática jurídica, son parte de un lenguaje que supone un paradigma jurídico que, a día de hoy, no es otro que el formalista. Ese lenguaje, llevado al extremo, se torna pétreo y hace que los conceptos del Derecho aparezcan frente al alumnado como verdades institucionales que él sólo debe aprender y recitar de memoria. Uno de los grandes problemas de esa manera de enseñar el contenido jurídico es que hace que el estudiante se olvide de lo que son las palabras jurídicas: frutos de convenciones legislativas y acuerdos políticos, mas no verdades científicas a descubrir. El gran impugnador de la verdad y el conocimiento es el filósofo alemán Friedrich Nietzsche (1844-1900), quien en la década de los 70 del siglo XIX escribe los siguientes textos: Sobre el pathos de la verdad (1872) y Sobre verdad y mentira en sentido extramoral (1873). En ambos se pregunta por el lenguaje y la verdad, realizando una crítica a la elaboración de conceptos, la actitud que promueven y el aislamiento de la ciencia al que conducen. Cree observar una salida al estado de las cosas recurriendo al arte. En este breve trabajo pretendo señalar que las ideas de Nietzsche pueden enriquecer la manera en que reflexionamos sobre las palabras de la ley entendidas como verdades en el aula.
Neuroprotective Effect of Naringin on Acrylamideinduced Cytotoxicity in U87MG Cells and Wistar Rats: An in-vitro and in-vivo Study
Authors: Vineela Sathuluri , Manga Devi Chinta , Santhrani Thakur
Published: August 2023

Acrylamide (ACR) is a potent neurotoxic to humans and animals. Neuroprotective effect of naringin was evaluated on ACR induced cytotoxicity using U87MG cells as in-vitro model and rat as in vivo model. ACR (50 mg/kg, i.p.) and Naringin (50 & 100 mg/kg) were administered to rats for 4 weeks. After 4 weeks, rats were sacrificed and sciatic nerves were isolated to determine the biochemical and apoptotic parameters. The exposure of U87MG cells to ACR reduced cell viability.  Pretreatment of cells with 5–300 Î¼g/ml naringin before ACR treatment signiï¬cantly attenuated ACR cytotoxicity in a dose-dependent manner. Naringin down-regulated the Bax and up-regulated the Bcl2 protein expression levels and also scavenged ACR induced free radicals in rats. In conclusion, our results indicated that pretreatment with naringin protected cells and rats from ACR-induced cytotoxicity and the neuroprotective effect was due to its antiapoptotic and antioxidant potential.
Potential Toxic Elements Load and their Health Risk Assessment in Vegetables Grown in Nsukka Area of South-Eastern Nigeria
Authors: Odum P. U. , Ekere N. R. , Abugu H. O. , Ihedioha J. N. , Nwoke S. U. , Ezike C. C. , Eze S. I.
Published: August 2023

Seven potential toxic elements (PTEs) (Cr, Pb, Zn, Ni, Cd, Co, and Fe) were assessed in some selected vegetables collected from Nsukka agricultural areas. Flame Atomic Absorption Spectroscopy was used to determine the Potential Toxic Elements (PTEs). The human health risk evaluation was performed and the average detectable concentration of the PTEs were all within the permissible limit of WHO/FAO. The highest concentration of Cr (0.1750±0.1543) was found in Solanum aethiopicum fruits from Opanda in Uzo-uwani, Pb (0.6667± 0.1443) in yellow Capsicum annuum L. seeds from Opanda in Uzo-uwani, Zn (2.9441 ± 1.7382) in Solanum melongen fruits from Opi-Agu, Ni(0.3761 ± 0.1184) in Gongronema latifolium leaves in Uzo-uwani, Cd (0.0703 ± 0.0316) in Solanum melongen fruits from Opanda in Uzo-uwani, Co (0.0485± 0.0346) in red Capsicum annuum L. seeds from Opanda in Uzo-uwani and Fe (13.2460 ± 1.3633) in Solanum melongen fruits from Opanda in Uzo-uwani. The health risk assessment of the PTEs showed that only Pb has the hazard quotient in children to be above one in Solanum melongen seed of Opi-Agu. However, the health risk associated with the consumption of Cr, Zn, Ni, Co, Cd and Fe were not as high as Pb. The Total Hazard Index (THI) of the PTEs was above 1 for children in Solanum melongen seed, and Solanum aethiopicum leaf. Therefore, the consumption of Solanum melongen fruits and Solanum aethiopicum leaf can be considered not safe for children. Other vegetables assessed did not constitute much potential health risk for both adults and children concerning the HI and HQ evaluated.
Potential Protective Effect of Magnesium Supplementation on Nickel Induced Hepatotoxicity in Albino Wistar Rats
Authors: Khiari Mohamed , Kechrid Zine , Klibet Fahima , Saoudi Mongi
Published: August 2023

Nickel is considered one of the most harmful heavy metals on human health. This experimental study was designed to investigate whether magnesium supplementation has any influence on nickel-induced toxicity in albino rats. Twenty one adult rats were divided into three groups of seven animals each group. The first group was used as a control and received saline solution. The second group was administered with nickel sulfate (2.0 mg/100 g, i.p) and the third group was given both nickel sulfate (2.0 mg/100 g, i.p.) and magnesium sulfate (300 mg/kg, i.p) simultaneously on alternate days. Body weight gain was recorded regularly. After 21 consecutive days, cellular functions were evaluated by biochemical and oxidative stress markers. The nickel sulfate-treatment decreased body weight gain in rats. Nickel treatment produced also oxidative injury characterized by an increase in glucose level, enzymes markers activities, lipid profile and total proteins and bilirubin concentrations. Simultaneously, glutathione level (GSH) and catalase activity was diminished in liver tissue. These results are further substantiated with obviously changes in hepato- histoarchithecture. However, the treatment with magnesium ameliorated the previous parameters and resulted in an improvement of the histopathological lesions. Our results suggest that magnesium supplementation may be effective in reducing nickel oxidative damage.
Evaluation of Analgesic, Antidiarrheal and Hypoglycemic Activities of Wendlandia paniculata (Roxb.) DC Leaves Extract using Mice Model
Authors: Mahmudul Hasan Mohammad , Sabbir Hossain Md. , Abdullah Taher Mohammad , Rahman Tauhidur
Published: August 2023

The leaves of Wendlandia paniculata (Roxb.) DC is a rare folk medicine among tribal people even though there is no scientific literature available regarding its pharmacological potentials. This study aimed to evaluate the effects of crude methanol extract of W. paniculata (Roxb.) DC. Leaves in mice model. The in vivo glucose-lowering capacity of methanolic crude extract was analyzed utilizing the well-known tail tipping method. The central and peripheral analgesic activity was evaluated using the ‘tail flick' and writhing assay respectively. The anti-diarrheal activity was evaluated using the method of castor oil-induced diarrhea in mice. As a result, oral administration (400 mg/ kg) of the extract resulted significant (P<0.001) delay in response to pain and inhibition of acetic acid-induced writhing response. The results were comparable to the respective standards morphine (2 mg/kg) and diclofenac (50 mg/kg). Likewise, maximum reduction (p<0.05) of blood glucose (32.3%) was observed 180 min after oral intake(400 mg/kg) of the extract compared to the 47% of the standard glibenclamide. Moreover, a reduction of diarrheal feces was observed 45.83% (p<0.001) compared to standard loperamide 70.83%. The in vivo bioassays confirmed that the crude methanol extract of leaves of W. paniculata possesses significant analgesic (central, peripheral) and antidiarrheal activity with mild glucose-lowering activity. Isolation of bioactive compounds is needed to justify the molecule responsible for the activity.
Acute, Sub-Acute and Genotoxicity Assessment of Cocculus hirsutus Hydroalcoholic Leaf Extract in Wistar Rats
Authors: Sankar Gorla Uma , Koteswara Rao G. S. N. , Kulandaivelu Umasankar , Reddy Alavala Rajasekhar , Prasad Panda Siva , Kolakota Rajkiran
Published: August 2023

Acute (0, 500, 1000 and 2000 mg/kg) and 28-day (0, 100, 200 and 400 mg/kg) toxicity assessments of Cocculus hirsutus hydroalcoholic leaf extract (CH-Ex) were performed in Wistar rats consistent with OECD guidelines 423 and 407 respectively. Average body weights were recorded, blood and biochemical parameters were analyzed and histopathological studies were performed. At doses (12.5–100 Î¼g/ml), genotoxicity assessments were conducted on pUC 19 plasmid by evaluating DNA damage protection. Acute toxicity assessment categorized CH-Ex as safe and non-toxic (category 5). The 28-day toxicity assessments showed no significant (p>0.05) changes in body weights, hematology and histopathology. At 400 mg/kg females exhibited a slight decline in SGPT, creatinine and BUN levels, while male rats exhibited a slight enhancement of SGOT and ALP levels (p<0.05). CH-Ex exhibited strong ability to protect DNA damage from oxidative stress in a dose-dependent manner.
Efficient Decolorization of Dye Acid Blue 113 by Soil Bacterium Bacillus subtilis RMLP2
Authors: Kumar Singh Pradeep , Pratap Singh Rajat , Singh Pankaj , Lakhan Singh Ram
Published: August 2023

In this study, a bacterial strain was isolated from soil and tested for the decolorization of azo dye Acid Blue 113 (AB 113). Decolorization of azo dyes by means of physico-chemical method is not environmentally friendly thus an alternative method based on bacteria was employed for decolorization of AB 113. The color removal studies were performed using Bushnell and Hass medium amended with AB 113 dye. Bacterial isolate Bacillus subtilis RMLP2 was identified by 16S rRNA gene sequence analysis. The effect of various physico-chemical parameters such as incubation condition, pH, temperature, carbon source, nitrogen source and dye concentration on decolorization of AB 113 by Bacillus subtilis RMLP2 were studied. The bacterial isolate showed the remarkable higher percentage (92.71%) of color removal of dye AB 113 at 100 mg/L concentration, 35oC, pH 7 during 72 h of incubation period under static condition. Yeast extract and glucose was found as best nitrogen and carbon source for efficient decolorization of dye. These results confirmed that the Bacillus subtilis has enormous ability to degrade dye AB 113 present in textile effluents.
Overview on Alzheimer’s Disease
Authors: Argaw Marshet Getachew , Bandaru Nagaraju
Published: August 2023

The world wide spread dementia of Alzeheimer disease is estimated to be as high as 24 million and it is hypothesized to be double every 20 years through 2040 resulting to a costly risk of the disease. Alzehimer disease is the main cause of dementia and is manifested by a gradual loss of cognitive function which is initially begin with deterioration of memory. Before death, the patient is fully dependent on their care givers. The main mechanism underlying the neuropath logical changes in Alzheimer patient are remaining unknown. But mainly they may be affected by both environmental and genetic factors. The hall mark pathology of Alzheimer disease are mainly accompanied by the presence of reactive microgliosis and the loss of neurons, white matter and synapses3.
Effect of Glyphosate on the Generation Parent and Four Successive Generations to Daphnia magna
Authors: El Joumani H. , El Alami M. , Naciri M.
Published: August 2023

This present study focuses on assessing the toxicity of glyphosate on Daphnia magna. The first part of this work was devoted to evaluate the acute and chronic toxicity of the herbicide studied according to the Moroccan standards ISO 6341 and ISO 100706. Analysis of the test results revealed that glyphosate is toxic to D. magna. This effect is marked by short-term responses at high concentrations, immobility of juveniles (24h), and chronic disturbances (21d) onthe growth and reproduction of this species. Then, the second part was dedicated to evaluating the toxicity of glyphosate over four successive generations from the F0 mother generation to the F4 daughter generation. The results show that the toxic effect of glyphosate was more pronounced in the F4 daughter generation than in the F0 parent generation.
Evaluation of Water Quality Pollution Indices for Heavy Metal Contamination Monitoring in Surface Water of Sutlej River (India)
Authors: Singh Brraich Onkar , Jassal Reetu
Published: August 2023

Globally, heavy metal contamination in aquatic environment is a growing dilemma and currently reached at an alarming rate. Surface water receives metal contamination both naturally and anthropogenically. A study was conducted during October 2018 – Dec 2019 to examine the present status of heavy metal pollution in the river Sutlej (Downstream junction of Buddha Nullah), Punjab. The prime thrust is to determine the heavy metal concentrations (Arsenic, Nickel, Cadmium, Cobalt, Chromium, Boron, Manganese, Copper, Iron, Lead and Zinc) of surface water from two points at the location site and to determine the water quality indices (Heavy metal pollution index, heavy metal evaluation index and degree of contamination). Heavy metal analysis has been done using inductively coupled plasma atomic emission spectrophotometer. The results of this study showed that the average concentration of heavy metals such as As, B, Cd, Co, Cr, Cu, Fe, Mn, Ni, Zn and Pb were 0.123?g/l, 0.144 ?g/l, 0.047 ?g/l, 0.059 ?g/l, 0.189 ?g/l, 0.281?g/l, 1.424?g/l, 0.097?g/l, 0.291?g/l, 0.904 ?g/l and 0.631 ?g/l respectively. The overall mean concentration of heavy metals was observed in the following order Fe >Zn>Pb>Cu>Ni>Cr>B>As>Mn>Co>Cd. The HPI and HEI (water quality indices) for As, Fe, Mn, Ni, Zn, Pb, Cd, Cr and Cu were 503.05, 55.55 respectively. It is concluded that the study area is critically polluted with heavy metals that are lethal to aquatic life and humans.
A Review on the Occurrence, Exposure, and Health Impacts of Bisphenol A
Authors: Sharma Prince , Sharma Khushboo , Sharma Geetika , Chadha Pooja
Published: August 2023

Bisphenol A (BPA) is one of the emerging contaminants associated with deleterious health effects on both public and wildlife and is extensively incorporated into different industrial products. BPA is ubiquitously and frequently detected in the environment and has become a serious health issue due to its presence in food organisms and drinking water. The distribution of BPA has recently become an important issue worldwide, but investigations on the toxicity of BPA remain limited. A review of the literature reveals that BPA has a widespread presence in environmental media, such as indoor dust, surface water, sediments, and sewage sludge. In the present review, an overview of the research studies dealing with the occurrence, fate, exposure, and toxicity of BPA is discussed. Recent studies have raised worry over the potentially harmful implications of BPA exposure in humans and wildlife. However, further investigation on the potential risks of BPA to humans and its mechanisms of toxicity should be conducted to better understand and control the risks of such novel chemicals.
Therapeutic Potential of Pomegranate Juice in Wistar Rats against Aluminium Induced Neurotoxicity
Authors: Ramesh V. , Rai Rajalakshmi , Pai Mangala M. , Joy Teresa , Jiji P. J. , Blossom Vandana
Published: August 2023

Neurodegenerative disorders are the major challenges faced by the global health care system in recent years. It is a well-known fact that a number of environmental as well as lifestyle factors are responsible for neurodegenerative diseases and the contribution by aluminium (Al) plays a major role in this. A diet containing considerably high traces of Al may cause neurotoxicity leading to memory loss, impaired coordination as well as a cognitive disturbance. The present study is designed to evaluate the neuroprotective role of Pomegranate Juice (PJ) since it is rich in polyphenols that have antioxidant properties. We evaluated neurodegenerative changes induced by AlCl3 in the hippocampus of Wistar rats as well as cognitive changes displayed by them. Then compared it with that of PJ treated rats which were previously administered with AlCl3. A significantly decreased (p<0.001) number of viable neurons were seen, in different regions of the hippocampus in the AlCl3 administered rats in comparison to the animals of the control group. However, the number of viable neurons significantly boosted (p<0.001) in PJ treated rat hippocampus. This suggests that neurotoxic changes induced by the aluminum can be ameliorated by treatment with PJ.
Multidisciplinary Approach to the Management of Aluminium Phosphide Poisoning – Experience from a Tertiary Care Hospital
Authors: More Dheeraj B. , Malve Harshad , Wankhede Mahendra N.
Published: August 2023

A usual ingredient of rodenticide, aluminium phosphide is known for its poisoning which happens to be one of the common causes of suicides in India. Signs and symptoms of toxicity with aluminium phosphide are wellknown. Circulatory failure plays an important role in mortality with aluminium phosphide poisoning. Aluminium phosphide poisoning is associated with high mortality as there is no specific antidote available yet. There is a need for correct treatment approach to manage this fatal poisoning. In this retrospective analysis we present a data of forty cases registered at a tertiary care hospital in Mumbai. We developed a multidisciplinary treatment approach to aluminium phosphide poisoning which may help in better patient outcomes. Correct treatment protocol with supportive therapy resulted in better survival in these patients. Hence we propose this aggressive, appropriate management with continuous haemodynamic monitoring and multidisciplinary treatment approach to reduce the mortality in aluminium phosphide poisoning.
Amelioration of Streptozotocin Induced Cytotoxicity by Mimosa pudica Root Extract - A Proteomic Based In-Vitro Study
Authors: Jamadagni Pallavi S. , Pawar Sharad D. , Jamadagni Shrirang , Chougule Shridhar , Wanjari Manish , Gautam Manish , Gaidhani Sudesh , Gurav Arun , Shrikanth N.
Published: August 2023

The in-vitrocytotoxicity was studied in a pancreatic cell line (RIN5F) using streptozotocin-induced cellular damage. The Cytotoxic dose of aqueous and hydro-alcoholic extracts of Mimosa pudica root powder before and after streptozotocin treatment was studied and protein expression was explored. Both the extracts were subjected to metabolite analysis by LCMS. Mimosa pudica root powder extracts prevented Streptozotocin-induced cellular damage. Proteomics studies indicated both aqueous and hydro-alcoholic extracts of Mimosa pudica regulate proteins related to insulin secretion, glucose uptake, and insulin resistance with marked changes in proteins involved in insulin secretion.  The study first time reports cytotoxicity of Mimosa pudica in RIN5F cells and explores protein expression after Mimosa pudica treatment. It was also observed that the abundance of Mimosine is more in Hydro-alcoholic extracts as compared to aqueous extracts.
Hazard Curves for Reliability Assessment of Strip Footings on Spatially Varying Cohesive Soils
Authors: MERT Ahmet Can , YAZICI Gökhan , KHAN BABA ZADEH Hadi
Published: August 2023

The present study aimed to create a series of hazard curves against maximum total settlement and angular rotation of strip footings for probabilistic shallow foundation design on clays. Random field finite element method (RFEM) was adopted with elasto-plastic clay-like soil behavior, deformation modulus (Ed) and shear strength parameters (c and ) were employed as random field inputs. Parameters were defined and assigned to the analysis models with varying correlation lengths (h, v). Models have been iteratively solved one thousand times, and output distributions of maximum settlement and angular rotations were recorded. Probability density functions (PDF) were fitted to the outputs, and probability of failure (Pf) for footing deformation limits was subsequently estimated. Proposed hazard curves for two anisotropy and three variability categories were developed employing the estimated Pfs. The method proposed has been validated using an independent database of in-situ results, and a worked example was provided to illustrate the implementation of the process. The key contribution of the research is to form hazard curves for shallow foundations considering elasto-plastic soil behavior with the impact of all influencing parameters, respecting the limit values for foundation deformation in the design codes. The proposed technique offers a probabilistic evaluation of strip footings with spatial variation of clayey soils and a valid method for the reliability-based design of foundations in the serviceability limit state.
Fractional-Valued Modal Logic and Soft Bilateralism
Authors: Piazza Mario , Pulcini Gabriele , Tesi Matteo
Published: August 2023

In a recent paper, under the auspices of an unorthodox variety of bilateralism, we introduced a new kind of proof-theoretic semantics for the base modal logic \(\mathbf{K}\), whose values lie in the closed interval \([0,1]\) of rational numbers [14]. In this paper, after clarifying our conception of bilateralism – dubbed “soft bilateralism” – we generalize the fractional method to encompass extensions and weakenings of \(\mathbf{K}\). Specifically, we introduce well-behaved hypersequent calculi for the deontic logic \(\mathbf{D}\) and the non-normal modal logics \(\mathbf{E}\) and \(\mathbf{M}\) and thoroughly investigate their structural properties.
Czy Roman Ingarden był fenomenologiem?
Authors: Półtawski Andrzej
Published: August 2023

Roman Ingarden used to say that he is not sure whether he was a phenomenologist. This does
not seem to be just coquetry. Transcendental phenomenology in its official Husserlian version did
not achieve adequacy of describing our primary experience in its fullness because it began as a sort of science, in the attitude of an 'uninvolved observer'. Yet phenomenology postulated a separate
methodology, different from that of science, a methodology understood as building up a new
conceptual apparatus based on a full analysis of primary experience – and the phenomenologists
did achieve a great progress in this direction – the direction of transcending the limits of some sort
of analytic philosophy of 'pure consciousness' based on traditional concepts which phenomenology
could seem to be at the beginning. Husserl oscillated between the 'dogmatic' and 'critical'
motive discerned in his thought by Ernst Tugendhat: between accepting consciousness as a sphere
of absolute insights and seeing such insights as an asymptotic limit of investigation. A similar
duality exists also in Ingarden's thought. This duality could have been a motive of Ingarden's
doubts.
Whiteheadowskie "eternalia" i Ingardenowskie czyste jakości idealne – problem związków koniecznych
Authors: Żuchowski Piotr
Published: August 2023

As far as existence of enduring subjects of change is concerned, Roman Ingarden's substance
ontology stands in direct opposition to Whitehead's process metaphysics. However, with regard to
domain of necessary relations, both systems are deeply platonic. Thus in this paper I pursue
towards revealing some parallels and differences between both systems regarding views on ideal
entities, necessary relations and pure possibilities. I examine whether having assumed contrary
concepts of reality (substantial/procesual) both philosophers are forced to accept diverse conclusions
in respect to ideal entities domain. I also point out some crucial problems that are to be found
in both systems: what is the ground of necessary relations – is it a nature of so called ideal qualities, or is it content of ideas (Ingarden); is it an individual or a relational essence of eternal
objects, so called "primordial nature of God", or evolving actuality (Whitehead). Finally
I investigate whether points of convergence between both concepts could serve as a basis for some
modifications to overcome relevant problems.
Influence of Precision Nutrient Management on Dry Matter Accumulation and Partitioning of Rice in Southern Odisha
Authors: Sagar Lalichetti , Maitra Sagar , Singh Sultan , Sairam Masina
Published: August 2023

Background: The nutrient management practices are largely known to influence dry matter accumulation and translocation in rice. However, the role of precision nutrient management in dry matter partitioning to the reproductive parts of rice is still unexplored. Methods: The present trial was conducted during boro season of 2021-22 at PG Experimental Farm, MSSSoA, CUTM, Odisha. The experiment was laid out in randomized block design with 11treatments that were replicated thrice. The treatments examined under the investigation were namely, absolute control, 75% recommended dose of fertilizer (RDF), 100% RDF, 125% RDF, 75% RDF fb nano urea spray @ 2ml/L at panicle initiation, 100% RDF fb nano urea spray @ 2ml/L at panicle initiation, leaf colour chart (LCC) 3 basednitrogen management, LCC 4 based nitrogen management, sufficiency Index (SI)-based N management at a threshold value less than 90%, Nutrient expert (NE) based nutrient recommendation, Rice crop manager (RCM) based nutrient recommendation. Result: The results of the study indicated that SI-based N management at a threshold value less than 90% results in highest allocation, shoot dry matter to the panicle (53.46%); while, absolute control of nutrients resulted in highest percentage allocation of shoot dry matter to culm (23.72%) and leaves (33.88%) during maturity.