bluuebunny/crossref_metadata_2025 huggingface dataset:
Sağlık Hizmetleri Meslek Yüksekokulu Öğrencilerinin Merhamet Düzeyleriyle Yaşlı Ayrımcılığına Yönelik Tutumları Arasındaki İlişkinin Değerlendirilmesi
Authors: Çakmak Rezzan , Acar Zeynep , Akkaya Sema , Özcan Müesser
Published: January 2025

Bu çalışma, sağlık alanında eğitim alan öğrencilerin merhamet düzeyleri ile yaşlı ayrımcılığına yönelik tutumlarının tanımlanması ve merhamet düzeyi ile yaşlı ayrımcılığına yönelik tutum arasında ilişki olup olmadığının belirlenmesi amacı ile yapılmış ilişkisel tarama türünde bir çalışmadır. Araştırma, olgu analizi de içerdiğinden niteliksel olma özelliği de göstermektedir. Araştırmada Sağlık Hizmetleri Meslek Yüksekokulu’nda öğrenim gören üç farklı programdaki 189 öğrenciden veri toplanmıştır. Veri toplama araçları olarak; ‘Sosyodemografik Veri Toplama Formu’, ‘Merhamet Ölçeği’, ‘Yaşlı Ayrımcılığı Tutum Ölçeği’ kullanılmıştır. Bunun yanı sıra, araştırmacılar tarafından oluşturulan 2 ayrı hipotetik olgu geliştirilmiş ve bu olgularla ilgili açık uçlu sorular verilerek araştırmacılardan cevaplamaları istenmiştir. Araştırmanın sonucunda; katılımcıların Merhamet Ölçeği toplam puan ortalamasının 100,22 ve Yaşlı Ayrımcılığı Tutum Ölçeği toplam puan ortalamasının 83,48 olduğu, merhamet düzeylerinin yüksek ve yaşlıya yönelik olumlu tutuma sahip oldukları, ayrıca ölçek puanları arasında anlamlı bir ilişki olduğu; merhamet düzeyi arttıkça yaşlıya yönelik olumlu tutumun arttığı belirlenmiştir.
Deprem ve Göç İlişkisi Üzerine Sosyolojik Bir Değerlendirme
Authors: Topçu Damla
Published: January 2025

Depremler insanlar üzerinde yıkıcı etkiler bırakmakla birlikte insanların zorunlu göç etmesine de neden olmaktadır. Geçmişten günümüze dünyada depremlerin göçlere neden olduğu bilinmektedir. Türkiye’de de depremlere bağlı göçler gerçekleşmektedir. Son yüzyılın en büyük afeti olan 6 Şubat 2023 tarihli Kahramanmaraş depremleri de birçok can ve mal kaybına neden olmuş ve zorunlu göçe sebebiyet vermiştir. Tüm göç türlerinde olduğu gibi deprem göçleri de basit bir yer değiştirme hareketi olmayıp göç öncesi ve sonrasıyla bir bütünlük arz eden ve yeni toplumsal, kültürel, psikolojik ve ekonomik yaşamları ve sorunları beraberinde getiren bir süreç olarak görülmektedir. Bu çalışmada deprem ve göç ilişkisi anlaşılmaya çalışılmış ve deprem göçünden sonra karşılaşılabilecek sorunlar üzerinde durulmuştur. Ayrıca göç teorileri üzerinden de deprem göçü sonuç kısmında değerlendirilmeye çalışılmıştır. Depremin neden olduğu zorunlu göçler, geçici ve kalıcı olarak gerçekleşmekte ve bu göçler ekonomik, sosyal, kültürel ve psikolojik birtakım sorunları da beraberinde getirmektedir. Deprem nedenli zorunlu göçlerde itici ve çekici faktörler etkili olmakta, kalıcı ve geçici göçler yakın çevreden uzak çevreye doğru gerçekleşmekte, akrabalar ve iş imkânları göç yönünde belirleyici rol oynamaktadır. Bu çalışmada teorik verilerden hareketle deprem ve göç ilişkisi sosyolojik olarak değerlendirilmeye çalışılmıştır.
“Mikro” ile “Makro”nun Mutsuz Evliliği: Klinik Sosyal Hizmet ve Toplulukla Çalışmanın Birlikteliği Mümkün mü?
Authors: Varlıklar Demirkazık Çiçek Nilsu
Published: January 2025

Makro uygulamanın bir müdahale yöntemi olan toplulukla çalışma ve mikro uygulamanın bir müdahale alanı olan klinik sosyal hizmet, çok uzun zamandır gerek literatürde gerekse pratikte birbirlerinden ayrı alanlar olarak ele alınmaktadır. Halbuki sosyal hizmetin bilgi, değer ve beceri temeli bize bunun tam tersini söyler; sosyal hizmete içkin pek çok özellik bu ayrışmayı anlamsız kılar. Sosyal hizmet eğitimi ve uygulaması çokdisiplinliliğe bu kadar vurgu yaparken, yapılan her araştırma mikro-mezo-makro önerilerle bitirilirken birliktelik üzerinde durmak yerine alanı niye keskin çizgilerle ayırıyoruz? Bu makale dünyadan mikro-makro ortaklığıyla ilgili iyi uygulama örneklerini derleyerek odak noktasını ayrışmadan ziyade birlikteliğe çekmeyi amaçlamaktadır. Dünyadaki konjonktürel durum ve sosyal bilimlerdeki tartışmalarla şekillenen sosyal hizmet eğitimi ve uygulamasındaki mikro-makro ayrışması tartışılmıştır. İyi uygulama örnekleri kadına yönelik şiddet, sağlık, eğitim ve insan hakları alanlarından seçilerek mikro ve makronun ortak ve birbirini tamamlayan/kapsayan yanlarına vurgu yapılmıştır.
Ruh Sağlığı Alanında Sosyal Hizmeti Yeniden Konumlandırmak: Eleştirel Bir Değerlendirme
Authors: Takak Ömer
Published: January 2025

Medikal modele dayalı olarak kurumsallaşan modern tıbbın, disiplinlerarası teori ve yaklaşımlara ihtiyaç duyduğu en önemli ihtisas alanlarından biri psikiyatri ve ruh sağlığıdır. Ancak modern psikiyatri disiplini, uzun yıllar boyunca ruhsal sorunların tanı ve tedavisinde medikal modele dayanmış ve bu alanın egemenliğini tek başına üstlenmiştir. 1960'larda başlayan anti-psikiyatri hareketiyle birlikte, ruh sağlığı alanının tıp disiplini tarafından hakimiyet altına alınması eleştirilmiştir. Bu dönemdeki düşünürler, bireylerin bedenlerinde ve davranışlarında normalin ve patolojik olanın sınırlarını belirleme sürecinde modern tıbbın sahip olduğu iktidarı eleştirmiş ve alternatif yaklaşımlar ortaya koymuştur. Bu tartışmalar ekseninde; sosyoloji, psikoloji ve sosyal hizmet disiplinlerinin teori ve yaklaşımları ruh sağlığı alanının medikal modelden biyopsikososyal modele evrilmesine katkı sunmuştur. Günümüzde, psikiyatri ve ruh sağlığı sorunlarının tanı ve tedavi yöntemlerinde baskın gücü tıbbi bilgi oluştursa da bu alanda, bütüncül bir bakış açısına doğru meyleden bir paradigma değişiminden söz edilir. Ancak bu çalışma, ruh sağlığı alanındaki sosyal hizmet uygulamalarının medikal modelin ilkelerini eleştirmeden benimseme riski taşıdığını iddia etmektedir. Bu nedenle çalışmada, medikal modele yaslanan psikiyatri disiplininin ruh sağlığı alanındaki hâkim konumu tartışmaya açılmıştır. Ruh sağlığı alanında eleştirel ve baskı karşıtı sosyal hizmet yaklaşımlarına neden ihtiyaç duyulduğu gündeme getirilerek sosyal hizmet bu alanda yeniden konumlandırılmaya çalışılmıştır.
Consultancy Measure in Türkiye: Current Status, Problems and Solution Suggestions
Authors: Korkmaz Burak Can , Demiryürek Yavuzhan Barış , Akdemir Zeynep
Published: January 2025

Child welfare is a critical issue worldwide. Countries apply various protective and preventive measures in this area. In this sense, Türkiye started implementing the Consultancy Measure in 2005. The Consultancy Measure ensures that children are supported together with their families by strengthening them. No review study has been found regarding the Consultancy Measure. Thus, this review examines the Consultancy Measure based on laws and current literature findings. The family functionality that improves thanks to the Consultancy Measure increases the well-being of both the child and the parents. The deficiencies in the implementation of the Consultancy Measure, which is claimed to be successful in terms of its results, are highlighted by many studies. There is a consensus in the literature on the proposal to establish a unit solely responsible for implementing the Consultancy Measure decisions due to the high workload and the need to strengthen the feedback mechanism. In this regard, the Consultancy Measure application can support the child and the family much more effectively if policymakers make some improvements. It can be said that the Consultancy Measure, which aims to strengthen the child with the family, is a successful application that can be taken as an example by other countries.
Yeşil Sosyal Hizmet Bağlamında Sosyal Hizmet Öğrencilerinin Elektromanyetik Kirlilik Farkındalığı: Çoklu Zeka Yaklaşımının Rolü ve Etki Eden Diğer Değişkenler
Authors: Duran Resul
Published: January 2025

Bu çalışma, sosyal hizmet bölümünde öğrenim gören öğrencilerin elektromanyetik kirlilik farkındalığını ve bu farkındalığın doğacı zeka ile diğer faktörlerle olan ilişkisini incelemeyi amaçlamaktadır. Çalışmada, nicel araştırma yöntemlerinden betimsel ve ilişkisel tarama modelleri kullanılmıştır. Türkiye'deki devlet ve özel üniversitelerdeki sosyal hizmet öğrencilerinden oluşan 436 kişilik bir örneklem ile veri toplanmıştır. Araştırmada kullanılan anket, demografik bilgiler, elektromanyetik kirlilik farkındalığı ve çoklu zeka ölçeğini içermektedir. Bulgular, öğrencilerin büyük bir kısmının elektromanyetik kirlilik konusunda orta seviyede farkındalık sergilediğini göstermektedir. Çeşitli sosyodemografik değişkenlerin farkındalık düzeyleri üzerinde anlamlı etkileri olduğu saptanmıştır. Ayrıca, öğrencilerin bilgi düzeyi, tutumları ve deneyimlerinin de farkındalıklarını etkilediği tespit edilmiştir. Bunun yanı sıra, doğacı zekânın elektromanyetik kirlilik farkındalığı ile anlamlı bir ilişkiye sahip olduğu ve bu farkındalığı önemli ölçüde artırdığı saptanmıştır. Sonuç olarak, sosyal hizmet öğrencilerinin elektromanyetik kirlilik farkındalığının artırılması için çevresel konuların eğitim müfredatına daha fazla entegre edilmesi gerektiği vurgulanmıştır. Bu bulgular, pratikte sosyal hizmet eğitimi programlarının çevresel sürdürülebilirlik ve farkındalık konularında daha etkin hale getirilmesi gerektiğine işaret etmektedir.
An Overview on the China Oil and Gas Market
Authors: Stelian Grasu
Published: January 2025

The article presents China’s oil and gas market, outlining its legal framework regulatory authorities of the market transport and distribution entities. Furthermore, the article discusses the primary strengths of China’s oil and gas sector, including extensive government support, rising domestic demand, and substantial investments in both strategic reserves and international partnerships. It also identifies areas of vulnerability, such as heavy reliance on imports, regulatory unpredictability, aging infrastructure, and environmental concerns, which challenge industry stability. Lastly, the SWOT analysis highlights key opportunities for growth in technology and innovation and market liberalization identifying external and internal risks.
Does Competition Make Businesses Resilient?
Authors: Jain Ravi , Poudel Rajeeb , Rogers Nina
Published: January 2025

This study investigates the relation between industry-level competition and the stock market's response to an exogenous shock. Specifically, we utilize the stock market's reaction to the terrorist attacks on September 11, 2001, which caused a significant market decline. Our findings reveal that firms operating in highly concentrated industries (lower competition), as measured by the Herfindahl index, experienced more pronounced negative returns following the attacks. Therefore, firms in less competitive fields may not be prepared for the unexpected. These results support the notion that competition bolsters business resilience to shocks and underscore the importance for investors to consider product market structures when evaluating firm performance.
Exam Proctoring in Online Business Education: Empirical Insights and Strategic Recommendations
Authors: Wuthisatian Rattaphon , Thenetsunthorn Namporn
Published: January 2025

This study examines the impact of exam proctoring on student performance in online MBA courses. Following the literature, this topic remains relatively understudied in graduate-level online business courses, particularly those focusing on economics. Using data from two sections of an online MBA economics course – one with proctored exams and one without – the study identifies a significant performance gap, with students in the proctored setting achieving lower scores. The findings further suggest that proctoring methods and students' comfort with proctoring technology can influence performance. Based on these results, strategic recommendations for improving exam practices in online MBA programs are provided.
The Influence of Fashion Creep on Dress Etiquette: Is Your Organization Marked Safe?
Authors: Hunter Debra Y. , Ogungbure Akins
Published: January 2025

As consumers navigate a world increasingly influenced by digital media, globalization, and progressive social norms, their fashion choices often serve as a form of personal expression and identity. Though individuals are encouraged to exercise freedom of expression, certain espoused fashion statements in public settings challenge socially acceptable societal norms and business etiquette. Thus, business etiquette and historical trends are marked “unsafe” from the ever-changing fashion industry trends. Evolutions in fashion and variations in cultural trends continue to challenge traditional dress norms in the workplace, formal public establishments, and classrooms across America. If inconsistent with organizational norms, these changes influence unfavorable perceptions of constituents and the respective organizations. Managing these impressions becomes critical for decision-makers desiring to protect an organization’s reputation and brand image. This paper explores the underlying dynamics shaping dressing norms, the paradigm shift, influences on professional attire, and outcomes associated with style selections. To embrace the changes and protect company images, we recommend continuous evaluation and reinforcement of dress code policies. We examine External Conformity Theory and Impression.
LDHA- Mediated Histone Lactylation Promotes the Nonalcoholic Fatty Liver Disease Progression Through Targeting The METTL3/ YTHDF1/SCD1 m6A Axis
Authors: Meng J , Yan C , Liu J
Published: January 2025

Nonalcoholic fatty liver disease (NAFLD) is characterized by elevated hepatic lipids caused by nonalcoholic factors, where histone lactylation is lately discovered as a modification driving disease progression. This research aimed to explore the role of histone 3 lysine 18 lactylation (H3K18lac) in NAFLD progression using a high-fat diet (HFD)-treated mouse model and free fatty acids (FFA)-treated L-02 cell lines. Lipids accumulation was screened via Oil Red O staining, real-time quantitative polymerase chain reaction (RT-qPCR), western blotting, and commercially available kits. Similarly, molecular mechanism was analyzed using immunoprecipitation (IP), dual-luciferase reporter assay, and RNA decay assay. Results indicated that FFA upregulated lactate dehydrogenase A (LDHA) and H3K18lac levels in L-02 cells. Besides, LDHA-mediated H3K18lac was enriched on the proximal promoter of methyltransferase 3 (METTL3), translating into an increased expression. Moreover, METTL3 or LDHA knockdown relieved lipid accumulation, decreased total cholesterol (TC) and triglyceride (TG) levels, and downregulated lipogenesis-related proteins in FFA-treated L-02 cell lines, in addition to enhancing the m6A and mRNA levels of stearoyl-coenzyme A desaturase 1 (SCD1). The m6A modification of SCD1 was recognized by YTH N6-methyladenosine RNA binding protein F1 (YTHDF1), resulting in enhanced mRNA stability. LDHA was found to be highly expressed in HFD-treated mice, where knocking down LDHA attenuated HFD-induced hepatic steatosis. These findings demonstrated that LDHA-induced H3K18lac promoted NAFLD progression, where LDHA-induced H3K18lac in METTL3 promoter elevated METTL3 expression, thereby promoting m6A methylation and stabilizing SCD1 via a YTHDF1-dependent manner.
A Closed Circulation Langendorff Heart Perfusion Method for Cardiac Drug Screening
Authors: Deflers C , Doñate Puertas R , Lechene P , Mateo P , Lefebvre F , Fischmeister R , Pidoux G
Published: January 2025

Cardiovascular diseases represent an economic burden for health systems accounting for substantial morbidity and mortality worldwide. Despite timely and costly efforts in drug development, the cardiovascular safety and efficacy of the drugs are not always fully achieved. These lead to the drugs’ withdrawal with adverse cardiac effects from the market or in the late stages of drug development. There is a growing need for a cost-effective drug screening assay to rapidly detect potential acute drug cardiotoxicity. The Langendorff isolated heart perfusion technique, which provides cardiac hemodynamic parameters (e.g., contractile function and heart rate), has become a powerful approach in the early drug discovery phase to overcome drawbacks in the drug candidate's identification. However, traditional ex vivo retrograde heart perfusion methods consume a large volume of perfusate, which increases the cost and limits compound screening. An elegant and cost-effective alternative mode for ex vivo retrograde heart perfusion is the constant-flow with a recirculating circuit (CFCC), which allows assessment of cardiac function using a reduced perfusion volume while limiting adverse effects on the heart. Here, we provide evidence for cardiac parameters stability over time in this mode. Next, we demonstrate that our recycled ex vivo perfusion system and the traditional open one yield similar outputs on cardiac function under basal conditions and upon β-adrenergic stimulation with isoproterenol. Subsequently, we validate the proof of concept of therapeutic agent screening using this efficient method. β-blocker (i.e., propranolol) infusion in closed circulation countered the positive effects induced by isoproterenol stimulation on cardiac function.
Can Buckwheat Affect Health and Female Reproductive Functions?
Authors: Sirotkin AV
Published: January 2025

The aim of the present narrative review is to summarise the existing knowledge concerning physiological and reproductive effects of buckwheat, its mechanisms of action on various targets, as well as outlines the direction of the further studies of this functional food plant. Search for literature was performed in agreement with the PRISMA criteria in Cochrane Library, Pubmed, Web of Science, SCOPUS databases between the year 1995 and 2023. Words used to search were buckwheat, review, fertility, ovarian and mechanisms. The current review of the available literature demonstrates the high nutritional value of buckwheat, as well as high contents and number of regulatory molecules in this functional food plant. These molecules can, via multiple signalling pathways, affect a wide spectrum of physiological processes and illnesses, which suggests a therapeutic value of buckwheat substances. Furthermore, recent reports demonstrate ability of buckwheat extract to directly affect basic ovarian cell functions (proliferation, apoptosis, viability, steroidogenesis). On the other hand, understanding the character and applicability of buckwheat influence on female reproductive processes requires further studies.
Physiology and Pathobiology of Perivascular Adipose Tissue: Inflammation-based
Authors: Muffová B , Králová Lesná I , Poledne R
Published: January 2025

Perivascular adipose tissue (PVAT) envelops the majority of systemic vessels, providing crucial mechanical support and vessel protection. In physiological conditions, PVAT releases various bioactive molecules, contributing to the anti-inflammatory environment around neighboring vessels. However, in conditions like obesity, PVAT can exacerbate cardiovascular issues such as atherosclerosis. Communication between PVAT and nearby vessels is bidirectional, with PVAT responding dynamically to signals from the vasculature. This responsiveness positions PVAT as a promising indicator of vascular inflammation. Recently, the role of PVAT in the CVD risk prediction is also greatly discussed. The objective of this review is to summarize the current state of knowledge about the PVAT function, its role in physiologic and pathophysiologic processes and its potential in CVD risk prediction.
Teaching Political Science with Pop Culture
Authors: Schenk Marie
Published: January 2025

Political science is a discipline devoted to understanding how people behave within systems of power. However, many undergraduates have only studied politics in the context of courses that ask them to memorize a series of dates and events. Even engaged students can struggle to shift their perspective to the kind of analysis political scientists are used to. I propose an alternative tool for teaching complex political science concepts: pop culture, specifically blockbuster films. I highlight two examples: teaching about ethical AI with Captain America: Winter Soldier and teaching about descriptive representation with Barbie. The benefits of teaching with pop culture go beyond advertising. They give students an inroad for talking about complex ideas in a seminar setting, which builds camaraderie, develops students’ confidence, and prepares them for a successful college career of learning.
Collaborative co-education as a facilitator of high impact learning experiences
Authors: Vann Elizabeth
Published: January 2025

Research has demonstrated that high impact practices – including community-based learning, research, collaborative work, and capstones – may be even more impactful when they operate together. However, designing and executing student learning experiences that employ more than one high impact practice can be challenging and burdensome. This paper uses examples from the Social Policy Analysis (SOPA) Capstone program in the Department of Political Science at Rice University to consider how a collaborative and co-educational pedagogy may help to support the creation and delivery of multi-faceted high impact student learning opportunities. The program’s co-educational approach brings community partners, graduate students, and undergraduate students together with course instructors to serve as both teachers and learners. I propose that, despite notable challenges, this approach alleviates some of the burdens that come with facilitating high impact experiences while also providing students with opportunities to learn and practice democratic forms of citizenship and governance.
Machine learning-based screening of asthma biomarkers and related immune infiltration
Authors: Zhong Xiaoying , Song Jingjing , Lei Changyu , Wang Xiaoming , Wang Yufei , Yu Jiahui , Dai Wei , Xu Xinyi , Fan Junwen , Xia Xiaodong , Zhang Weixi
Published: January 2025

Introduction

Asthma has an annual increasing morbidity rate and imposes a heavy social burden on public healthcare systems. The aim of this study was to use machine learning to identify asthma-specific genes for the prediction and diagnosis of asthma.

Methods

Differentially expressed genes (DEGs) related to asthma were identified by examining public sequencing data from the Gene Expression Omnibus, coupled with the support vector machine recursive feature elimination and least absolute shrinkage and selection operator regression model. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene set enrichment analysis and correlation analyses between gene and immune cell levels were performed. An ovalbumin-induced asthma mouse model was established, and eukaryotic reference transcriptome high-throughput sequencing was performed to identify genes expressed in mouse lung tissues.

Results

Thirteen specific asthma genes were obtained from our dataset analysis (LOC100132287, CEACAM5, PRR4, CPA3, POSTN, LYPD2, TCN1, SCGB3A1, NOS2, CLCA1, TPSAB1, CST1, and C7orf26). The GO analysis demonstrated that DEGs linked to asthma were primarily related to positive regulation of guanylate cyclase activity, gpi anchor binding, peptidase activity and arginine binding. The renin-angiotensin system, arginine biosynthesis and arginine and proline metabolism were the key KEGG pathways of DEGs. Additionally, the genes CEACAM5, PRR4, CPA3, POSTN, CLCA1, and CST1 expression levels were positively associated with plasma cells and resting mast cells. The mouse model revealed elevated nos2 and clca1 expression in the asthmatic mouse group compared with that in normal mice, which was consistent with the findings in asthmatic patients.

Discussion

This study identified new marker genes for the prediction and diagnosis of asthma, which can be further validated and applied clinically
Application of biomaterials in mesenchymal stem cell based endometrial reconstruction: current status and challenges
Authors: He Ling , Li Qianrong
Published: January 2025

Severe endometrial injuries may cause thin endometrium and intrauterine adhesion in women which can result in uterine factor infertility. Current treatments, including surgical separation of adhesions and hormonal regeneration of the endometrium, often fail to prevent re-adhesion and achieve satisfactory reproductive results. Recently, mesenchymal stem cells (MSCs) have become a promising new treatment for IUA. However, challenges such as cell survival and transplantation limit the effectiveness of MSC therapy. Researchers have explored various approaches to enhance the therapeutic efficiency of MSCs. Among these, biomaterials have been frequently employed due to their biocompatibility, degradability, and ability to provide a conducive environment for cell growth. This review discusses the use of various biomaterials in MSC-based therapies for endometrial reconstruction and summarizes evidence from preclinical and clinical studies, highlighting the efficacy and safety of these biomaterials. The review also addresses future directions in this field, such as advances in biomaterial engineering, new biomaterials currently under investigation, and personalized medicine approaches. This review emphasizes the significance of biomaterials in MSC-based therapy for endometrial reconstruction and provides practical guidance for developing new materials and treatment protocols for clinical applications.
Wikipedia and indigenous language preservation: analysis of Setswana and Punjabi languages
Authors: Minhas Shahid , Salawu Abiodun
Published: January 2025

The survival of a language is important for several reasons, some of which are to maintain cultural identity, tradition and wisdom. Therefore, people always try to protect their cultural identity, tradition, and wisdom, thus preserving and promoting their languages. Similarly, indigenous languages, Setswana and Punjabi face challenges in preservation and promotion in this digital world, but their survival is important for preserving cultural identity and heritage. This study examines Wikipedia’s role in promoting and preserving Setswana and Punjabi. The research is framed by the Ethnolinguistic Vitality Theory (EVT), which suggests that language survival lies in reclamation, revitalization, and reinvigoration. A quanti-qualitative approach is used to investigate the issue, integrating quantitative metrics from Wikipedia’s statistical pages with qualitative content analysis of the articles. Data were collected from May 2022 to May 2024, focusing on article counts, edits, active editors, new pages, top edited pages, and views. The study reveals significant disparities in content quality and community engagement between the Setswana and Punjabi Wikipedia editions. It highlights the challenges and opportunities of Wikipedia for enhancing the visibility and usage of indigenous languages. The findings show that Punjabi Wikipedia has a much larger content volume and user base, but comparatively lower recent activity and collaborative depth compared to Setswana Wikipedia. (Setswana) Tswana Wikipedia, while smaller in content volume, demonstrates a more engaged and active editing community, reflected by a higher depth score and a larger number of active users. This indicates a different stage of development and community involvement between the two language editions. Also, the study provides practical recommendations for Wikipedia contributors, language activists, and policymakers, suggesting that increased participation and strategic initiatives can significantly bolster the preservation efforts for these languages.
Risk factors associated with pregnancy loss after single euploid blastocysts transfer
Authors: Dong Xiaohui , Shi Juanzi , Liu Xiaohua , Liu Danmeng , Li Wei , Zhao Xiaoli , Xue Xia
Published: January 2025

Objective

To detect primary factors influencing pregnancy loss(PL) following the transfer of euploid blastocysts?

Design

Retrospective cohort study.

Methods

To identify potential factors influencing PL, we analyzed multiple variables in both the PL group and the live birth group. In order to minimize the impact of confounding factors, various variables were included in a binary logistic regression analysis.

Results

The PL rate after the transfer of euploid embryos is 13.3% (36 cases of PL out of 270 cases of single embryo transfer). Compared to the live birth group, the PL group had lower E2 levels (2376.03 ± 1553.25 vs 3412.88 ± 2116.47, P=0.007), higher LH levels (2.66 ± 2.47 vs 1.96 ± 1.52, P=0.023) on trigger day of fresh cycle, fewer retrieved oocytes (10.08 ± 5.01 vs 12.77 ± 7.20, P=0.044), higher female BMI (23.26 ± 3.27 vs 22.05 ± 2.69, P=0.016), higher proportion of maternal smokers (50% vs 20.51%, P<0.001), and more day 6 blastocyst transfers ((38.89% vs14.53, P=0.001). Logistic regression analysis revealed that higher LH levels(OR=1.304, 95%CI=1.054-1.613, P=0.015), low E2 levels (OR=0.438, 95%CI=0.242-0.794, P=0.007) on trigger day of fresh cycle, maternal smoking(OR=4.574, 95%CI=1.974-10.601, P<0.001), and day 6 blastocyst transfer(OR=4.610, 95%CI=1.907-11.141, P=0.001) appeared to be associated with increased risk of PL following the transfer of euploid embryos.

Conclusions

Maternal smoking, day of blastocyst transferred, estradiol (E2) and Luteinizing hormone (LH) levels on trigger day of corresponding fresh cycle for transferred blastocysts are all associated with PL following transfer of euploid embryos.
Cellular aspects of immunity involved in the development of atherosclerosis
Authors: Khalaf Khalil , Chamieh Marc , Welc Natalia , Singh Chandpreet , Kaouk Joanne Lynn , Kaouk Aiden , Mackiewicz Andrzej , Kaczmarek Mariusz , Perek Bartlomiej
Published: January 2025

Atherosclerosis, previously regarded as a lipid storage disease, has now been classified as a chronic inflammatory disease. The hardening of arterial vessels characterizes atherosclerosis due to the accumulation of lipids in the arterial walls, eliciting an inflammatory response. The development of atherosclerosis occurs in various stages and is facilitated by many clinical factors, such as hypertension, hyperlipidemia, and inflammatory status. A large arsenal of cells has been implicated in its development. This review will summarize the phases of atherosclerotic formation and all the cells involved in either promoting or inhibiting its development.
Risk factors and clinical outcomes of cytomegalovirus infection following haploidentical hematopoietic stem cell transplantation in patients with aplastic anemia: a single-center retrospective study
Authors: Feng Jia , Zhang Xinhe , Tan Zhengwei , Zhao Yuechao , Hu Huijin , Chen Junfa , Wu Liqiang , Yu Qinghong , Wu Dijiong , Ye Baodong , Liu Wenbin
Published: January 2025

Background

Cytomegalovirus (CMV) infection remains a critical cause of mortality after allogeneic hematopoietic stem cell transplantation, despite significant advancements in CMV prevention and treatment with the introduction and widespread use of letermovir. However, in China, due to limitations in the availability and cost of medications, some patients still face challenges in accessing letermovir. For this subset of the population, exploring the risk factors for CMV infection remains significant in predicting its occurrence.

Methods

Therefore, a retrospective analysis was conducted on 88 haploidentical hematopoietic stem cell transplant recipients over 4 years.

Results

Our study results indicate that chronic graft-versus-host disease (cGVHD) is an independent risk factor for CMV infection following haploidentical hematopoietic stem cell transplantation (Haplo-HSCT). Survival analysis reveals lower survival rates in the refractory CMV infection (RCI) group compared to the non-RCI group, with patients having lower viral loads demonstrating higher rates of seroconversion and improved survival under the same treatment regimen.

Conclusion

Strengthening the monitoring of CMV-DNA in post-transplant patients, actively promoting hematopoietic recovery, preventing the occurrence of CMV infection, and controlling the development of CMV infection can lead to better survival outcomes for patients with aplastic anemia undergoing Haplo-HSCT.
Interprofessional approach to personalized medication management and therapy optimization in IBD care
Authors: Fleischmann Daniel , Binder Benedicta , Huss Muriel , Elger Tanja , Wolf Claudia , Loibl Johanna , Tews Hauke Christian , Kandulski Arne , Schmid Stephan , Müller Martina , Kratzer Alexander
Published: January 2025

A considerable number of patients with chronic inflammatory bowel diseases (IBD) are required to manage extensive polypharmaceutical regimes, which significantly elevates the risk of drug–drug interactions. Also, the disease’s impact often leads to the consumption of additional self-medication by the patients such as naturopathic remedies to alleviate disease-induced suffering and nutritional supplements to compensate for malabsorption syndromes inherent to the condition. There is a well-established consensus that polymedication coupled with unregulated supplementary intake can jeopardize the safety of drug therapy. Despite this, pharmaceutical co-supervision—proven to mitigate adverse drug events and enhance patient adherence to treatment—is generally lacking in routine clinical settings. Furthermore, the assessment of individual therapy adherence, a crucial predictive factor for therapeutic outcomes, is frequently suboptimal. In response to these issues, this study implemented an interdisciplinary approach wherein a team comprising medical and pharmaceutical professionals conducted a comprehensive survey coupled with a medication review for patients attending an IBD outpatient clinic. Employing an IBD-specific questionnaire alongside the patients’ documented medication regimens enabled the identification and subsequent discussion of current therapeutic concerns and potential medication-related risks during follow-up consultations. This intervention aimed to bolster individual patient satisfaction and enhance medication safety, ultimately fostering sustained success in IBD management.
When a sore throat turns into deadly multiple serous cavity effusions: the role of Prevotella oris in rapidly progressing infection—a case report
Authors: Zhang Fangqi , Wang Juan-Li , Zhu Jian , Si Shaokui , Guo Hao , Yue Xiang , Wen Wei
Published: January 2025

Severe infections that develop rapidly from ordinary symptoms not only increase patient misunderstandings but also lead to excessive detection of these symptoms by physicians. This case study describes a 19-year-old male individual who initially presented with a sore throat and subsequently developed multiple serous cavity effusions that lead to septic pulmonary embolism and septic shock. After multiple cultures of the patient’s sputum yielded no identifiable pathogenic bacteria, the metagenomic next-generation sequencing (mNGS) revealed Prevotella oris as the predominant pathogen present in both the patient’s peripheral blood and the pericardial drainage fluid. The subsequent antibiotic treatment, guided by the mNGS results, along with surgical drainage and mediastinal irrigation, effectively controlled and ultimately cured the patient’s condition. This case is unique because it is the first to show that normally colonizing Prevotella can also cause fatal multiorgan infection as an opportunistic pathogen in a previously healthy young person with no immune-related diseases. The aim of this study is to expand clinical awareness of this common symptom and its potentially fatal outcome.
Effect of afzelin on inflammation and lipogenesis in particulate matter-stimulated C. acnes-treated SZ95 sebocytes
Authors: Hong Ji Yeon , Choi Yong Hee , Roh Yoon Jin , Lee Mi-Kyung , Zouboulis Christos C. , Park Kui Young
Published: January 2025

Background

Afzelin, a flavonoid (kaempferol 3-O-α-L-rhamnopyranoside) isolated from Thesium chinense, is known for its potent anti-inflammatory properties. However, its effects on the molecular aspects of inflammation and lipogenesis in SZ95 sebocytes has not been investigated.

Objective

This study aimed to (i) investigate inflammatory and sebum secretion changes when a Cutibacterium acnes-treated immortalized human sebocyte cell line (SZ95) is exposed to particulate matter (PM) and (ii) examine the effects of afzelin on these.

Methods

To investigate the effect of afzelin on PM- and C. acnes-treated SZ95 sebocytes, we injected heat-killed C. acnes into SZ95 cells to induce acne-like status. Thereafter, the SZ95 sebocytes were treated with PM and subsequently with afzelin. The gene expression profile was determined using real-time polymerase chain reaction analysis, and protein expression was confirmed via western blotting and immunofluorescence. Intracellular lipid droplet formation was investigated using Nile Red O staining.

Results

PM treatment upregulated the mRNA and protein expression levels of inflammatory cytokine and lipogenic genes in C. acnes-treated SZ95 sebocytes. Furthermore, intracellular lipid-droplet accumulation increased when C. acnes-stimulated SZ95 cells were exposed to PM. Interestingly, the upregulated inflammatory and lipogenic gene expression induced by C. acnes and PM was attenuated by afzelin treatment.

Conclusions

This study's findings indicate that PM potentially aggravates acne by acting on both inflammation and sebum secretion. They also reveal afzelin's ability to suppress these phenomena by not only suppressing inflammatory cytokine expression but also inhibiting sebogenesis. These findings confirm afzelin's potential therapeutic role in improving PM-exacerbated acne.
Predictive value of the systemic immune–inflammation index for outcomes in large artery occlusion treated with mechanical thrombectomy—a single-center study
Authors: Qian Ao , Zheng Longyi , He Hui , Duan Jia , Tang Shuang , Xing Wenli
Published: January 2025

Background

The systemic immune–inflammation index (SII) is a composite and easily available inflammation index, which can quantitatively reflect the degree of inflammation. This study aims to investigate the predictive value of admission SII for outcomes of large artery occlusion treated with mechanical thrombectomy (MT).

Methods

This retrospective study was conducted at Suining Central Hospital, Sichuan, China. Patients were stratified into quartiles based on their SII. The investigating outcomes included hemorrhagic transformation (HT), malignant brain edema (MBE), 90-day functional outcome, and mortality. The adverse function was defined as the modified Rankin Scale (mRS) score > 2 at the 90-day follow-up. Multivariate analysis was performed to explore the relationships between SII and outcomes. In addition, cases (distinguished from the aforementioned patients) treated with MT + mild hypothermia (MH) were also included to elucidate the relationships between SII/MH and outcomes in a new cohort.

Results

A total of 323 patients treated with MT were included. The observed HT, MBE, adverse function, and mortality rates were 31.9, 25.7, 59.4, and 27.9%, respectively. Multivariate analysis demonstrated that heightened SII was significantly related to HT (odds ratio [OR]: 1.061, 95% confidence interval [CI]: 1.035–1.086, p < 0.001), MBE (OR: 1.074, 95% CI: 1.045–1.103, p < 0.001), adverse function (OR: 1.061, 95% CI: 1.031–1.092, p < 0.001), and mortality (OR: 1.044, 95% CI: 1.018–1.070, p = 0.001), after adjusting sex, age, Glasgow Coma Scale (GCS) score at admission, initial National Institutes of Health Stroke Scale (NIHSS) score, baseline Alberta Stroke Program Early Computed Tomography Score (ASPECTS), present HMCAS, occluded vessel region, collateral score and successful revascularization. HT and MBE may partially account for patients with elevated SII’s adverse function and mortality. In addition, with the criterion of baseline ASPECTS ≤ 7, a total of 42 patients treated with MT + MH were enrolled to build up a new cohort combined with 72 patients treated with mere MT. The risk role of SII and protect effect of MH were identified for HT (SII—OR: 1.037, 95% CI: 1.001–1.074; MH—OR: 0.361, 95% CI: 0.136–0.957), MBE (SII—OR: 1.063, 95% CI: 1.019–1.109; MH—OR: 0.231, 95% CI: 0.081–0.653), and mortality (SII—OR: 1.048, 95% CI: 1.011–1.087; MH—OR: 0.343, 95% CI: 0.118–0.994).

Conclusion

Elevated SII was related to HT, MBE, 90-day adverse function, and mortality after MT. The MH may improve prognosis under high inflammation status.
Standard b-value DWI-derived stiffness index analysis may provide a way to evaluate the development of intracerebral hematoma
Authors: Li Qian , Mao Jin , Wang Qiyuan , Yao Liding , Xu Fangfang , Dong Fei
Published: January 2025

Background and purpose

The development of intracerebral hemorrhage (ICH) is closely related to mechanical forces. However, noninvasively evaluating mechanical forces for ICH patients in the current clinical setting is challenging. In this study, we aimed to build an easily accessible stiffness index (STI) and evaluate the stiffness of the perihematomal edema (PHE) region in ICH patients.

Materials and methods

In this retrospective study, two cohorts of 57 patients were included. One cohort (the exploratory cohort) comprised patients with both standard b-value diffusion-weighted imaging (sDWI) (b-values of 0 and 1,000 s/mm2, b0 and b1000) and higher b-value diffusion-weighted imaging (hDWI) (b-values of 200 and 1,500 s/mm2). Another cohort (the hemorrhage cohort) consisted of patients who were diagnosed with ICH and who underwent sDWI within 48 h from onset. The hDWI-based virtual shear modulus (μdiff) was calculated and correlated with the sDWI data in the exploratory cohort. In the hemorrhage cohort, STI maps that were used to estimate μdiff were generated. The mean STI (mSTI) and coefficient of variation (COV) of the STI were computed on the basis of the STI maps in the whole and largest-slice PHE regions.

Results

The STI could be calculated with the Equation 0.047697*S1000-0.022944*S0 + 5.359883, where S1000 and S0 represent the signal intensities of the b1000 and b0 images, respectively. In the whole and largest-slice PHE regions, both the mSTI and COV were correlated with the hematoma volume (p < 0.01), but neither were correlated with the time from onset.

Conclusion

The standard b-value DWI-derived stiffness index analysis may provide a noninvasive and easily accessible way to evaluate the development of ICH.
‘We don’t know nearly enough’: an online survey exploring perspectives of specialists who support children with brain-based visual impairments
Authors: Jakubowski Josephine Sabrina , May Eloise , Findlay Rebecca , McDowell Nicola , Simkin Samantha K. , Hamm Lisa M.
Published: January 2025

Introduction

Children with brain-based visual impairments (some of whom have a diagnosis of Cerebral Visual Impairment, or ‘CVI’) represent a growing and underserved population within vision services. These children often have more complex needs than those with ocular visual impairments and benefit from specialist support from multiple disciplines. This study aimed to understand the perspectives of these specialists in terms of their goals, views on collaboration, and understanding of the term ‘CVI’.

Methods

We invited a range of specialists who work with children with brain-based visual impairments, including educators, rehabilitation staff, clinicians, and family members, to complete an online survey between April 2023 and April 2024.

Results

The analysis included 94 respondents: 51 educators, 30 rehabilitation staff, 7 clinicians, and 6 family members. Respondents shared common goals of connecting with the child (87/94, 93%) and fostering their learning and development (82/94, 93%). However, respondents also noted some specific and divergent goals, which can be at odds with each other. Professional staff frequently identified family members as the most valuable source of information about their child’s vision (36/88, 41%), though family members expressed feeling under-valued. Transdisciplinary clinics were highlighted as a helpful model to provide quality child-centered care. Of the 73 professional staff who reported being familiar with the term ‘CVI’ (73/88, 83%), most (61/73, 84%) thought it was underdiagnosed, but respondents had different perspectives on what a diagnosis meant. Only 73% of professionals familiar with CVI reported receiving formal training about it.

Discussion

The varied goals and different perspectives on CVI create challenges to providing cohesive support for children with brain-based visual impairments. Increasing the availability of complementary formal training across disciplines and adopting transdisciplinary models of care are promising approaches to improve the quality of services.
Individual and combined effects of dietary vitamin intake on cognitive function in elderly adults: the potential mediating role of serum neurofilament light chain levels
Authors: Zhou Zhikui , Fan Baiyun , Chen Qiang , Li Xuezhong , Ke Xianjin
Published: January 2025

Background

Vitamins are essential micronutrients for the prevention and treatment of neurodegenerative diseases. The objectives of the present study were to evaluate the association between dietary vitamin intake and cognitive function in elderly adults and to explore the potential impact of serum neurofilament light chain (NfL) concentration.

Methods

Data from 468 elderly individuals, including information on the dietary consumption of 10 vitamins, were used. Cognitive performance was assessed according to a composite Z-score of the Animal Fluency Test (AFT), Consortium to Establish a Registry for Alzheimer’s Disease (CERAD), and Digit Symbol Substitution Test (DSST). Serum NfL levels were measured using a highly sensitive immunoassay. Bayesian kernel machine regression (BKMR) models were used to estimate the combined effects of vitamin mixtures on cognitive function.

Results

In both single- and multiple-vitamin models, individuals with a higher intake of dietary vitamin K exhibited greater global cognitive function, compared to those with a lower vitamin intake. BKMR revealed positive associations between vitamin mixtures and global cognitive function, AFT Z-scores, and DSST Z-scores. Individuals in the third vitamin K intake tertile exhibited lower serum NfL levels than those in the first tertile (regression coefficient, β = −0.16 [95% confidence interval −0.29 to −0.02]; p = 0.023). Serum NfL levels mediated the association between higher vitamin K intake and global cognitive function (8.73%).

Conclusion

Vitamin mixtures were positively associated with global cognitive function in elderly participants. The association between vitamin K intake and cognitive function may be mediated by serum NfL concentration.