bluuebunny/crossref_metadata_2025 huggingface dataset:
Epidemiological aspects of gonococcal infection in the arkhangelsk region
Authors: Baryshkov K V , Prib I D , Frigo N V , Solomka V S
Published: February 2022

The authors studied the incidence of gonococcal infection in the Arkhangelsk region in 2001—2011. They also analyzed gender and age distribution, social set-up, education level and marital status of patients. In areas with the low to moderate (Group I) and high (Group II) incidence, the authors analyzed such indices as density of the population, number of dermatovenerologists, territorial profile (agricultural or industrial depending on the branch) and transportation quality. In 2001—2011, the incidence of gonococcal infection in the Arkhangelsk region was falling down — from 187.4 per 100,000 people in 2001 to 78.9 per 100,000 people in 2011 (by 2.4 times). Substantial difference in the incidence rate was observed in different districts of the region. The authors revealed that young men aged 20—29 with secondary education, not engaged in public production, clerks or workers from industrial enterprises, not married, practicing often and sometimes unsafe sexual contacts with women belong to the risk group in terms of incidence of gonococcal infection in the Arkhangelsk region. The authors also revealed that living in big towns with well-developed heavy (machine building, shipbuilding), oil extraction and oil processing industry as well as transportation (in particular, marine and river transport) where young men are employed, and high migration of the population is observed (tourism, business travels, labor migration) may be a risk factor in terms of incidence and propagation of gonococcal infection in the Arkhangelsk region.
Results of the analysis of dermatovenereologic healthcare organizations activity in Russian Federation in 2012
Authors: KUBANOVA A A , KUBANOV A A , MELEKHINA L E , BOGDANOVA E V , BUTAREVA M M
Published: February 2022

The paper presents the analysis of the work of dermatovenereologic healthcare organizations in Russian Federation, rationality of hospital bed and day hospital bed usage, incidence and effectiveness of preventive control of sexually transmitted infections and skin disorders.
Efficacy of skin care products for acne patients
Authors: Araviyskaya Ye R , Sokolovsky Ye V
Published: February 2022

The article provides information about barrier skin properties in acne patients and analyzes the effects of topical and systemic drugs on the condition of the corneous layer as well as composition of highly specialized lipids and skin fat. It discusses the principles of patient management with the use of basic daily care products.
Role of neuromediators in the development of skin inflammation in patients with atopic dermatitis
Authors: KATUNINA O R , CHIKIN V V , ZNAMENSKAYA L F , INOYATOVA L A
Published: February 2022

Neurotransmitters such as neuropeptides and neurotrophins can have an effect on the development of a skin inflammatory reaction and itching as well as condition of nerve fibers. Goal. To assess the expression of neuropeptides and neurotrophins in the skin of patients with atopic dermatitis. Materials and methods. Expression of neuropeptides of substance P and SP-R receptor, calcitonin gene-related peptide (CGRP) and CGRP-R receptor, neurotrophin (nerve growth factor) and TrkA receptor as well as amphiregulin enhancing the growth of nerve fibers and semaphorin-3A terminating the growth of nerve fibers was determined in the skin of patients with atopic dermatitis based on the immunohistochemistry analysis method. Expression of protein PGP9.5 being a marker of nerve fibers was also determined. Results. The authors discovered penetration of nerve fibers expressing substance P and CGRP into the epidermis in patients with atopic dermatitis. Expression of the nerve growth factor and amphiregulin was discovered in epidermis but no expression of semaphorin-3A was discovered. Conclusion. Nerve fibers expressing neuropeptides such as substance P and CGRP can penetrate into the epidermis in patients with atopic dermatitis, which can maintain the inflammatory reaction and itching in such patients. Expression of the growth factors (nerve growth factor and amphiregulin) can contribute to the growth of nerve fibers and their penetration into epidermis against the background of the absence of any expression of semaphorin-3A inhibiting their growth.
Extracellular matrix of the skin: role in the development of dermatological diseases
Authors: RUKSHA T G , AKSENENKO M B , KLIMINA G M , NOVIKOVA L V
Published: February 2022

Extracellular matrix is a system of proteins and polysaccharides maintaining the structural integrity of an organ or tissue. At the same time, in addition to its “classical” function extracellular matrix components regulate many important processes including participation in the signal transmission, regulation of cell division and differentiation, which makes extracellular matrix molecules a prospective target for treatment of a lot of diseases.
Systemic treatment of severe forms of acne: experience of using Isotretinoin in the Russian Federation
Authors: KUBANOVA A A , ARAVIYSKAYA YE R , SOKOLOVSKY YE V , DVOROVA YE K , FADEYEVA YE I
Published: February 2022

The article presents the results of a large-scale Russian program of the follow-up and treatment of acne patients with Isotretinoin (Roaccutane). The analysis of the results included information about 1,349 acne patients. In 71% of patients, the therapy was initiated at the dose of 0.5-1.0 mg/kg of the body weight. The average duration of treatment was 21.5±0.16 weeks while the average course dose was 119.9±0.8 mg/kg of the body weight. As many as 96% of patients achieved a positive result; women demonstrated a higher improvement rate than men. On the whole, Roaccutane was well-tolerated while adverse effects included dry lips (43.4%), dry skin in different areas (12.45%), retinoid dermatitis (6.45%), epistaxis (2.45%), conjunctivitis (1.41%) and hoarseness (0.22%). The Russian experience of using Roaccutane confirmed high efficacy of the systemic therapy for severe forms of acne.
On the 90th anniversary of the dermatovenerology service of the Stavropol territory
Authors: Zemtsov M A , Chebotarev V V
Published: February 2022

The article discloses archival materials describing the establishment of the Dermatovenerology Institute and Dispensary in the Stavropol Territory as well as their growth and development. The article includes documents as of the 1920s and present-day photos.
Assessment of the efficacy of Betamethasone with Calcipotriol for isolated psoriatic nail affections based on optical coherent tomography
Authors: Neznakhina M S , Petrova G A , Garanina O Ye , Shlivko I L
Published: February 2022

Psoriatic nail affection is difficult to diagnose, especially if there are no specific skin changes, and is resistant to traditional treatment methods. The absence of any reliable diagnostics criteria often results in diagnostics errors, inadequate treatment and reduced life quality. Goal. To assess the efficacy of Daivobet for isolated psoriatic nail affections based on optical coherent tomography. Materials and methods. The study involved 10 patients (4 male and 6 female) aged 19—38 (mean age: 27.5 years) including four subjects with isolated psoriatic nail affections (oil spots and dotty cavities on the nail plate) and six subjects with psoriatic nail affections with paronychias (psoriatic plaques and thimble symptom on the nail folds and adjacent skin). The area of the psoriatic affection of the nail plate was 30%—70%. The efficacy of Daivobet and nail condition was clinically monitored by using the optical coherent tomography method and recording the NAPSI index. Tests were performed prior to the treatment and 3 and 6 weeks after the treatment onset. Results. A positive trend with regard to psoriatic paronychia in the form of regressed infiltration was observed against the background of treatment by Week 3 of the treatment, and complete regression of eruptions was observed by Week 6. In all of the subjects, a healthy nail plate grew by 2—3 mm and complete regression of the dotty cavities was observed during Week 6 of the study, which correlated with the reduced PASI index and positive trends based on optical coherent tomography data.
Determination of class M and G antibodies to T.pallidum antigens in patients with primary syphilis
Authors: Rotanov S V , Ermatova F A
Published: February 2022

The authors present the results of a study of blood serum samples obtained from patients with clinically diagnosed primary syphilis by the linear immunoblotting method to determine IgM and IgG antibodies to T. pallidum antigens, which enabled the authors to study the intensity of the humoral immune response to individual T. pallidum antigens at early stages of the infection. The humoral response by means of the synthesis of specific class M antibodies in case of primary syphilis was accompanied by the formation of Class G antibodies in most cases; the frequency of revealing Class M and G antibodies was as follows: TmpA antigen 100 and 98.68%; TpN47 90.79 and 97.37%; TpN17 90.79 and 89.47%; TpN 15 72.37 and 73.69% of all cases, respectively; the content of class G antibodies to each of the four T. pallidum antigens exceeded the levels of Class M antibodies by more than twice. Different profiles of the humoral immune response with the involvement of IgM and IgG antibodies distinguished by a more expressed synthesis of antibodies to any or several of T. pallidum antigens were discovered and characterized for the first time. The clinical sensitivity of the IgM immunoblotting method for diagnosing primary syphilis amounted to 85.53%, IgG immunoblotting 92.11%, which means that the method can be used to diagnose early forms of syphilis.
Ulceronecrotic Mucha Habermann’s disease: case study
Authors: Parfenova M A , Belousova I E , Samtsov A V
Published: February 2022

The rare dermatosis febrile ulceronecrotic Mucha Gabermann’s disease is described. Etiology, pathogenesis, clinical and pathomorphological criteria of diagnosis, treatment of the disease are discussed. Based on the literature review describes the historical and current data classification of the disease and patient management tactics.
Zinc, its biological role and use in dermatology
Authors: KHLEBNIKOVA A N , PETRUNIN D D
Published: February 2022

This literature review detines the biological role ot zinc in the human body, immune homeostasis and skin physiology as well as pathophysiology ot skin diseases. It describes the current range ot systemic and topical zinc preparations and their pharmacological characteristics. The review also describes skin diseases that may be treated with the use ot zinc preparations on a grounded basis, and discloses the clinical experience ot the use ot these drugs described in the world literature. It sets out certain recommendations tor using zinc preparations in clinical practice.
Systemic antibiotics therapy of acne: certain controversies
Authors: ARAVIYSKAYA YE R , SOKOLOVSKY YE V
Published: February 2022

The article presents intormation about systemic antibiotics treatment ot acne. The authors discuss issues such as indications tor the administration ot antibiotics, drug selection and combination with external drugs.
Skin moisturizing as a factor preventing premature skin ageing
Authors: Pashinyan A G , Heidar S A , Arutyunyan G B , Dontsova Ye V
Published: February 2022

The authors describe issues related to age-related changes in the skin. They present data confirming the clinical efficacy of hydration cosmetic drugs belonging to the Noreva Aquareva line by Laboratoires Dermatologiques d’Uriage aimed at renewing the natural moisture-preserving epidermis structure in patients with dry skin within a short period of time.
Russian Dermatovenerology in 1940—1949
Authors: Prokhorenkov V I , Belova-Rakhimova L V , Guzey T N
Published: February 2022

The history of development of dermatology in Russia and in the USSR in 1940—1949 is described.
Issues of the efficiency and safety of the immune-modulating therapy in the treatment of chlamydial and herpes infections of the urogenital tract
Authors: LETYAYEVA O I , GIZINGER O A , ZIGANSHIN O R
Published: February 2022

The authors conducted a randomized clinical and immunological study in 93 women of reproductive age suffering from chlamydial and herpes infections in the lower urogenital tract. They demonstrated high clinical, immunological and etiological efficiency of the complex therapy with the use of Lavomax.
Pharmacoeconomic aspects of treatment of psoriasis with biological drugs
Authors: Rudakova A V , Kubanov A A
Published: February 2022

Psoriasis is an autoimmune skin disease substantially reducing the patients’ quality of life. Practical application of biologic drugs made it possible to achieve substantial progress in the psoriasis therapy. Goal of the article: comparative evaluation of the efficacy of etanercept, infliximab, adalimumab and ustekinumab costs in psoriatic patients. Methods. The cost efficacy was evaluated based on the results of randomized placebo-controlled studies. The analysis was conducted by the cost/efficiency method from the point of view of the health care system. Reduction in the severity of the disease by the PASI index vs. baseline was used as a criterion to evaluate the clinical efficacy. The evaluation was carried out for a course of therapy lasting for 52 weeks; the analysis took into consideration data on all patients (both responding and not responding to the treatment in 12 weeks) as well as patients failing to respond to the treatment in 12 weeks and withdrawing from the therapy. Costs and clinical efficacy were assessed for the time period equal to one year. The costs per one patient achieving PASI 75 were taken as the cost/efficacy coefficient. Results: treatment with adalimumab was shown to be characterized by a lower cost/efficacy coefficient vs. etanercept; infliximab or ustekinumab. Withdrawal in case of non-responding patients in 12 weeks reduces the therapy costs by 17%—40%. In this case, adalimumab proves to be more cost efficient. Conclusions. Treatment of psoriatic patients with adalimumab is expedient from the clinical and economic points of view since it is characterized by the minimum cost/efficacy ratio against the background of high clinical efficacy vs. etanercept; infliximab or ustekinumab.
Angiolymphoid hyperplasia with eosinophilia and generalized affection of the skin
Authors: Martynov A A , Butareva M M , Glukhareva Ye V , Pirogova Ye V
Published: February 2022

Doctors from the State Research Center for Dermatology, Venereology and Cosmetology followed up a female patient with a rare diagnosis: angiolymphoid hyperplasia with eosinophilia. The clinical nature of the skin had a number of specific features: propagation of eruptions all over the skin as well as double-side scrotal lymphadenopathy. The count of eosinophils in the total blood count was normal, which complicated the diagnostics. The authors provide data from literature sources on the etiology and pathogenesis, clinical features, differential diagnostics methods and therapy of the disease.
TLR - possible molecular target for biologic psoriasis therapy
Authors: Katunina O R , Rezaykina A V
Published: February 2022

Target: studies of 2, 4, 9 types of TLR in the affected skin of patients with psoriasis with evaluation of morphometric indices. Маterial and methods. Immunohistochemical skin research at 15 patients, suffering from psoriasis (12 women and 18 men) in the age of 19-68 y.o. and at 10 healthy trial subjects. Results. The increased expression of TLR2 и TLR4 was revealed in the skin patients, suffering from psoriasis. Opinions. This fact enlarges considerably psoriasis pathogenesis perceptions and determines the new vector of research, forwarded to the search of the ethologic factor, as well as the optimization of existing methods of the systemic psoriasis therapy.
Issues of efficiency and safety of immunomodulating therapy in the treatment of the chlamydial and herpetic infection of the urogenital tract
Authors: LETYAEVA O I , GIZINGER O A , ZIGANSHIN O R
Published: February 2022

Target: to give the clinical and immunologic evaluation of the combined chlamydial and herpetic infection of the urogenital tract and to study the possibility of the immunomodulating therapy at this category of patients. Маterial and methods The open short term prospective randomized clinical and immunologic study comprises 93 women of reproductive age, suffering from chlamydial and herpetic infection of the low section of the reproductive tract. Besides the basic therapy (acyclovir 200 mg 5 times a day No7, azithromycin 1,0 No 1) the index group (n=52) received such immunomodulator as tiloron, the basic therapy group (n=4) received only basic therapy. The experimental group (n=50) comprised apparently healthy women, selected during prophylactic examinations. Results. After the monthly treatment in the experimental group Chlamydia was revealed at 12,1%, HSV at 9,7% of women. In the index group it was 1,9 and 3,8% accordingly. At the repeated control after a month in the index group Chlamydia was not revealed at у 98%, HSV - at 96,1%. It was 87,8 and 80,5% in the experimental group accordingly (р
Studies of T.pallidum proteome for the purpose of improving laboratory assessments for the syphilis diagnostics
Authors: ROTANOV S V , HAYRULIN R F , FRIGO N V
Published: February 2022

The review covers problems related to the ways of development of modern methods of laboratory assessment used for syphilis diagnostics on the basis of the use of specific antigens of the pathogenic agent. Results of studies of some immune proteome proteins of T.pallidum have been provided. The data on the possibility of their use for the development of new laboratory methods based on the detection of antibodies to Т. pallidum target proteins in blood serum samples of patients with different clinical forms of syphilis.
Psoriasis incidence and prevalence in the Russian Federation
Authors: ZNAMENSKAYA L F , MELEKHINA L YE , BOGDANOVA YE V , MINEYEVA A A
Published: February 2022

The article presents materials and analyzes the main trends in the epidemiology of psoriasis and follow-up of patients from this category in the Russian Federation for 2009—2011.
A comparative assessment of the efficacy of the treatment of patients suffering from common warts with the use of destructive methods
Authors: SHTIRSHNEIDER YU YU , VOLNUKHIN V A
Published: February 2022

Objective. To compare the efficacy of the treatment of patients suffering from common warts with the use of laser destruction methods using a diode laser with the wavelength of 0.81 μm, electrocoagulation and liquid nitrogen cryosurgery. Materials and methods. The sample comprised 75 patients suffering from common warts on their wrists. The patients were allocated to three groups, and their therapy included treatment with diode laser irradiation with the wavelength of 0.81 μm electrocoagulation and liquid nitrogen cryodestruction. The treatment efficacy was assessed by the frequency and terms of relapses, nature of the developing scar and presence or absence of dyspigmentation. Results. A positive effect was registered in 76% of the patients in case of laser destruction, in 56% of the patients in case of electrocoagulation and in 44% of the patients in case of treatment with liquid nitrogen; a satisfactory effect was registered in 16, 20 and 32% of the patients, respectively. Relapses were observed in 8, 24 and 24% of the patients, respectively. The following benefits of the treatment of common warts with diode laser irradiation vs. electrocoagulation and liquid nitrogen cryodestruction were revealed: less painful procedure, rare adverse reactions and shorter terms of operative wound epithelialization.
Optimizing the therapy of the erosive and ulcerative form of lichen acuminatus in the mucous coat of the oral cavity
Authors: SEDOVA L A , PERLAMUTROV YU N , TERESHCHENKO A V , OLKHOVSKAYA K B
Published: February 2022

Objective. To assess the clinical efficacy of an antioxidant therapy with Mexidol for the treatment of patients suffering from lichen acuminatus in the mucous coat of the oral cavity. Materials and methods. The study involved 62 patients suffering from the erosive and ulcerative form of lichen acuminatus in the mucous coat of the oral cavity. The severity of dermatosis was assessed based on the determination of the affected area of the mucous coat of the oral cavity. The activity of antioxidant protection was assessed based on the determination of the level of lipid peroxidation products, total antioxidant activity and individual antioxidants in the peripheral blood. Results. The use of Mexidol contributed to the remission in 53.13% and substantial improvement in 37.50% of the patients, which corresponded to the indices for the group of patients to whom Metypred was administered. The share of adverse effects when Mexidol was used was twice as low as in the group of patients who were taking Metypred. Conclusion. The use of an anti-oxidizing agent such as Mexidol reduces the intensity of inflammations and adverse effects and contributes to the epithelialization of erosions.
A study of the efficacy of using the Kartalin ointment in a complex with exogenous melatonin for psoriasis
Authors: DMITRUK V S , MARTYNOVA V G , KAMYSHNIKOVA O A , DMITRUK S I
Published: February 2022

A complex approach to the treatment of psoriasis, which includes topical drugs improving regenerative processes immediately in the skin in addition to systemic drugs, proves to be the most efficient one. The objective of the study was to assess the clinical efficacy of a medical complex including exogenous melatonin and Kartalin ointment for psoriatic patients. The study was based on the results of a study of 201 psoriatic patients who underwent treatment at the Dermatovenerology Clinic of the Siberian State Medical University. The clinical efficacy of the combination treatment for 35 days including joint application of standard treatment techniques, Kartalin ointment and exogenous melatonin was assessed. As a result of the study, the authors established that joint application of standard treatment techniques, Kartalin ointment and exogenous melatonin improves the treatment efficacy by 16.6%.
Differential approach to the selection of dermal and cosmetology products for the complex treatment of acne in women
Authors: GORYACHKINA M V , BELOUSOVA T A
Published: February 2022

The authors present current data about the epidemiology, clinical picture and principles of diagnostics and treatment of late-onset acne in women. The authors emphasize the leading part of endocrine and hormonal disorders and hyperandrogenism in women with late acne. They provide recommendations for basic skin care for women with the onset of acne at a mature age using medical and cosmetic products of the Matidiane line. The authors share their observations concerning the efficacy of using Matidiane medical and cosmetic products.
Immune and genetic mechanisms of infertility andreproductive function disorders associated with humanurogenital chlamydial infection
Authors: Plakhova K I , Rakhmatulina M R , Frigo N V , Galimov A R , Volkov I A , Vasil'eva E L , Plakhova K I , Rakhmatulina M R , Frigo N V , Galimov A R , Volkov I A , Vasiliyeva Ye L
Published: February 2022

This review covers current concepts of immune and genetic mechanisms of infertility associated with human urogenital chlamydial
infection. It describes studies of individual polymorphisms of genes coding cytokines and other immune system mediators. It also
presents the results of studies aimed at searching for genetic predisposition to the development of complications resulting in human
reproductive function disorders caused by past urogenital chlamydial infections.
Currentaspects of psoriasis phototherapy
Authors: Zhilova M B , Butareva M M , Volnukhin V A , Zhilova M B , Butareva M M , Volnukhin V A
Published: February 2022

The review covers current aspects of ultraviolet therapy for patients suffering from psoriasis. It describes mechanisms of action as well as early and remote side effects of the current phototherapy methods. The review also presents data from literature about the risk of their cancerogenicity. It also discusses approaches to the optimization of phototherapy in view of risks and benefits for the patient.
STD prevalence among patients from guz samara regional narcology dispensary
Authors: SHAKUROV I G , KORYAKIN S A , KUZNETSOVA YE D , KIRASIROV R K
Published: February 2022

Our goal was to study the epidemiological situation among drug addicts in the Samara region, the impact of drugs on sexual behavior and determination of the risk of STD infection. There was an anonymous STD questionnaire survey among drug addicts to achieve the goal. According to the study results, the STD morbidity among drug addicts is high, and they also demonstrate a risky sexual behavior, which makes it possible to assign them to an individual, the most dangerous risk group because they are out of control of medical care institutions and pose the maximum threat from the epidemiological point of view.
Using Heptral® (Ademetionine) to treat hepatic affections in leprosy patients
Authors: Degtyarev O V , Mesnyankina O A , Naumov V Z , Degtyarev O V , Mesnyankina O A , Naumov V Z
Published: February 2022

The article is devoted to the problem of chronic hepatic diseases in leprosy patients at the stage of long-term rehabilitation. The article focuses on the opportunity to use such hepatoprotector as Heptral® for the complex treatment of chronic hepatic affections
in leprosy patients, and presents the authors' clinical experience of studying the drug efficacy.
A case study of acrokeratosis paraneoplastica (Bazex syndrome)
Authors: Katkhanov A M , Katkhanova O A , Tlish M M , Katkhanov A M , Katkhanova O A , Tlish M M
Published: February 2022

This article presents data about the etiology, pathogenesis, clinical course and methods of treatment for a rare obligate paraneoplastic
dermatosis - the Bazex syndrome.
The authors share their own observations.
Linear dermatosis developed in infants against the background of allergicdiseases: a clinical study
Authors: Grebenyuk V N , Grishko T N , Chamurlieva M N , Sokolova A A , Grebenyuk V N , Grishko T N , Chamurliyeva M N , Sokolova A A
Published: February 2022

The article presents a clinical study of two cases when linear unilateral dermatosis developed in children suffering from allergic diseases: against the background of atopic dermatitis and obstructive bronchitis with signs of transformation into bronchial asthma.
Prospects of using proteome technologies in the diagnostics of sexually transmitted infections and skin diseases
Authors: Kitayeva N V , Frigo N V , Rotanov S V , Khairulin R F
Published: February 2022

The article presents data from the literature describing up-to-date syphilis diagnostics methods used in the Russian Federation. It
also describes main proteome techniques and gives the results of applying proteome technologies in the diagnostics of diseases
including infectious ones, and prospects and opportunities for using direct proteome profiling to develop a new method for syphilis
diagnostics are analyzed.
Assessment of the cytokine profile in psoriasis patients against the background of an immune-modulating therapy
Authors: OKHLOPKOV V A , MEDVEDCHIKOV E K , DOLGIKH T I , PRAVDINA O V , GORODILOV R V , ZARAYEVA I F
Published: February 2022

The authors examined the clinical effect and dynamics of immunological indices (IL-1, IL-6, TNF-, IFN-) at the progressing
and stationary stages of psoriasis with the administration of Stemokin®. A reliable reduction of IL-1, TNF- и IFN- was observed
against the background of treatment and was accompanied with an evident clinical effect. Two variants of the immune system
response were revealed for the complex therapy.
Clinical, molecular and genetic studies of efficacy and safety of using UV irradiation for psoriasis patients
Authors: Zhilova M B , Kubanov A A , Lesnaya I N , Frigo N V , Volkov I A , Znamenskaya L F , Volnukhin V A
Published: February 2022

The authors give the results of clinical, molecular and genetic studies of efficacy and safety of treatment of 87 patients suffering from extensive psoriasis with the use of UV irradiation of different spectral ranges. They showed that the administration of a course of treatment with the use of the PUVA therapy or narrowband medium-wave UV therapy with the wavelength of 311 nm does not result in the development of any clinically significant genetic mutations associated with the DNA excision repair system. They revealed that the GC genotype of the XPC gene in the 32828 site and CC genotype of the XPF gene in the 27945 site may be predictors of a pronounced therapeutic effect in treatment of patients with the use of phototherapy methods. The authors obtained data confirming a possible protective role of T>C polymorphism in the 27945 site of the XPF gene in the development of phototoxic reactions when psoriasis patients undergo an UV therapy.
Efficiency of using a narrow-band 311 nm mid-wavelength ultraviolet therapy at atopic dermatitis in children
Authors: BAKULEV A L , SLESARENKO N A , PLATONOVA A N , IGONINA I A , KULYAYEV K A
Published: February 2022

The article presents the results of using a narrow-band mid-wavelength ultraviolet therapy (311 nm) in 79 children suffering from with atopic dermatitis. The course of treatment comprised 15 to 20 sessions of ultraviolet therapy with the maximal dose of irradiation being not more than 0.15 J/cm2. The control group (n=35) received traditional therapeutic treatment with the use of standard schemes of dosing and drug administration, and did not differ from the main group of patients in age, duration or form of the disease. Clinical efficacy of the therapy was estimated according to the SCORAD index, Dermatological Index of the Symptom Scale and Children's Dermatology Life Quality Index. The efficacy of the narrow-band mid-wavelength ultraviolet therapy (311 nm) turned out to be very high, which is confirmed by earlier reduction of clinical symptoms among patients from this group than in the control group. The latter fact was also confirmed by the reduction of absolute values of the SCORAD index and Dermatological Index of the Symptom Scale (p
Assessment of the clinical efficacy of the administration of Phosphogliv in complex treatment of psoriasis patients
Authors: Orlov Ye V , Konnov P Ye , Kotelnikova Ye V
Published: February 2022

The article presents the results of a study of the clinical efficacy of the administration of Phosphogliv for psoriasis and its effect on
the functional and biochemical parameters as well as patients quality of life. The authors established that the administration of
Phosphogliv results in a considerable improvement of the course of extensive psoriasis and reduction in the activity of the inflammatory
process contributing to the normalization of the lipid composition of the blood serum at the expense of the lipotropic and
membrane stabilizing action.
Major directions in the development of diagnostics technologies indermatovenerology
Authors: Frigo N V , Lesnaya I N , Kubanov A A , Rotanov S V , Znamenskaya L F , Solomka V S
Published: February 2022

This review describes major directions in the development of laboratory diagnostics of STDs and dermatoses in the Russian
Federation. It also discusses strategic directions in the development of diagnostics departments in dermatovenerological institutions
(three-level structure of laboratory aid, centralization, automation, standardization of tests, external and internal laboratory quality
control, introduction of laboratory information technologies and laboratory information exchange systems). It also substantiates
the priority directions in the diagnostics of STDs (etiological diagnostics, acceleration of the cycle of laboratory tests for patients,
determination of the resistance of causative agents to antimicrobial drugs, molecular monitoring of the spreading of STDs) and
dermatoses (diagnosis verification, diagnosing an organ pathology, marker diagnostics, prevention and prediction of the efficacy
and safety of dermatosis treatment).
Role of vehicle in topical steroids: optimal composition and mode of action
Authors: ARAVIJSKAYA E R , SOKOLOVSKY E V , BAKHTINA S M , PCHELINTSEV M V
Published: February 2022

The article contains analysis of composition and action of classical dermatological forms and vehicles of modern topical steroids. The use of proper choice of a vehicle is stressed.
Potential and prospects of rendering high-end medical aid todermatovenerological patients
Authors: Martynov A A , Kubanov A A , Matushevskaya Yu I
Published: February 2022

The authors defined stages of development of high-end medical aid for skin and hypoderm diseases and presented particular features
of such aid based on their many years experience and analysis of normative and legal acts as well as methodical guidelines.
A study of the potential of regional medical institutions in rendering high-end dermatovenerological aid conducted by the authors
enabled them to substantiate further ways of development for this type of medical aid.
A case of successful application of the photodynamic therapy for a patientwith kaposis sarcoma of the penis
Authors: Molochkov A V , Kartashov a M G , Prokofiyev A A , Sukhova T Ye , Molochkov V A , Kaplan M A
Published: February 2022

The article describes a case of successful application of the photodynamic therapy for treatment of the classic type of Kaposis
sarcoma in the area of the glans of a 60-year-old patient.
Functions of Toll-like receptors as an inborn immunity component and their participation in the pathogenesis of dermatoses of different etiologies
Authors: KATUNINA O R
Published: February 2022

In addition to serving as a mechanical barrier protecting our organism from the damaging effect of different factors, our skin also takes part in immune reactions developing in case of microbial intervention. Toll-like receptors (TLR) mediating recognition of molecular structures of pathogens are expressed in skin cells of different types initiating the development of adaptive immune reactions when associated with different ligands. The review presents data on the structure and functions of TLR, their localization in skin compartments and their role in the pathogenesis of skin diseases being of infectious etiology and non-infectious origin.
IMPROVING PUPILS’ VOCABULARY MASTERY BY USING VIDEO SONGS
Authors: Ella Nanda , Sofian Sofian , Rosnija Eni
Published: February 2022

The research was aimed to improve pupils’ vocabulary by using video songs. This research was a classroom action research which done in two cycles. The subject of this research was the class A6 pupils of TK Immanuel. The researcher observed pupils’ improvement by collecting data through field notes, observation checklist and vocabulary test. The pupils’ behaviour towards the learning process was gathered by field note and observation checklist. The data of vocabulary was obtained by vocabulary test which was assessed through scoring rubric. The result showed those pupils’ problems in recognizing and mentioning the vocabulary had been solved by using video songs as the media of teaching. Furthermore, pupils’ interest in learning vocabulary also improved. It was shown by the pupils’ enthusiasm to pay attention in watching the video and singing together during teaching and learning process. As the conclusion, the media was able to be used in improving pupils’ vocabulary.
IMPROVING STUDENTS’ SPEAKNG SKILL IN THE ASPECT OF GRAMMAR AND VOCABULARY ABOUT DESCRIBING ANIMALS BY USING CUE CARDS MEDIA
Authors: Putri Dewi Sartika , Sada Clarry
Published: February 2022

This research aimed at improving the students’ speaking skill at grade VII of SMP Islamiyah Pontianak in the academic year of 2019/2020 through cue cards media. This classroom action research was conducted in three cycles; on November 14th, 21st and 28th respectively. It involved 22 seventh grader students as well as the English teacher as the collaborator. The data were taken from the observation, field notes and speaking task. The data of speaking was obtained by speaking task which was assessed through scoring rubric. The result showed that students’ problems in grammar and vocabulary had been solved by using Cue Cards media. The most interesting part of this research was, the cue cards could break the ice among the students as there are pictures and questions which stimulate students’ prior knowledge and could be used as handy clues for them during the learning process. Furthermore, the students’ speaking improved constantly from cycle 1 (the highest score was 48, 3 students got score 48), cycle 2 (the highest score was 64, 2 students got score 64) and cycle 3 (the highest score was 84, 6 students had not achieved the minimum score which is 75). Not only their individual speaking achievement got improved, but also their interest in learning. It was shown by the students’ enthusiasm to pay attention and involve actively in doing every activity during teaching and learning process by using cue cards. Keywords: Speaking, Cue Cards, Media
TEACHER'S EXPERIENCE IN TEACHING SPEAKING BY USING STAD
Authors: Ariesa Adha , Sudarsono Sudarsono , Suhartono Luwandi
Published: February 2022

This research was aimed to describe the teacher's experience in teaching speaking using STAD. The subject of this research was an English teacher of SMAN 10 Pontianak who was experienced in teaching English by using STAD. This research was a case study to describe the teacher's experience while using STAD in teaching speaking. The data were collected from interviews, audio-visual materials, and document reviews. The speaking score of 36 students from the Year-10 students of SMAN 10 Pontianak in Academic Year 2019/2020 was used in this research. The results showed that the STAD technique affected the students' speaking learning achievement as much as 9 out of 36 students experienced an increase in their score by 4%. Some internal factors contributed to those students' achievement, namely, students' contributions, motivating students, and improving student skills. Moreover, the findings revealed that some students did not achieve the goal of learning by using STAD. This is caused by several factors, namely managing time, managing class, and lack of speaking skills become the difficulties of this research.Keywords: Case Study, Experience, STAD, Speaking Skill.
La Hologenómica y su relación con el cáncer
Authors: Canon Cristian Arriaga , Espinosa Laura Contreras , Manríquez Rogelio Montiel , Suárez Daniela Venegas , Montalvo Luis Herrera
Published: February 2022

Un holobionte es considerado una entidad biológica asociada en simbiosis con microorganismos que complementan sus vías metabólicas, sus funciones fisiológicas y su variación genética. El término hologenoma se refiere a todo el contenido genético del holobionte, es decir, a la suma del genoma del hospedero, sus organelos junto con los genomas del microbioma que lo componen. En la actualidad se ha establecido que existe una relación entre el desarrollo de enfermedades y el microbioma de los humanos, por lo que en esta revisión se describirá el papel del hologenoma en el cáncer y las técnicas de secuenciación masiva en paralelo aplicadas en la hologenómica. El estudio de la hologenómica junto con las tecnologías en secuenciación y bionformática proporcionará información relevante para el desarrollo de nuevas herramientas diagnósticas y su posterior aplicación en la práctica clínica.
A CMOS Vector-Sum Phase Shifter for 5G mm-Wave Application
Authors: Kim Eunjung , Kim Younghwan , Jeon Sanggeun
Published: February 2022

This paper presents a wideband CMOS vector-sum phase shifter (VSPS) targeting the n260 band of 5G communication. A differential quadrature generator is implemented using a Marchand balun and two 90° coupled-line couplers to improve robustness to process and temperature variations. The quadrature vector signals are combined by a following vector modulator that adopts a double Gilbert-cell topology. The linearity and input-matching performance are enhanced at the expense of extra DC consumption by stacking a current source with high bias. The measurement shows that the VSPS provides a continuous 360° phase shift with an average insertion loss of 16.3 dB at 37 GHz. The root-mean-square (RMS) amplitude and phase errors maintain less than 1.5 dB and 4.9°, respectively, from 30.9 GHz to 41.7 GHz. The input-referred 1-dB compression point is 5.7 dBm at 38 GHz. It is also demonstrated by 484-state measurement that the phase and amplitude can be adjusted in a fine resolution.
An Active Shielding Control Method for a Wireless Power Transfer System under Misalignment Conditions
Authors: Ahn Jangyong , Kim Jedok , Park Dongryul , Kim Haerim , Ahn Seungyoung
Published: February 2022

This paper proposes a control method for an active shield system using an independent power source under misalignment conditions. The proposed method controls the current strength and phase of the shielding system according to magnetic field leakage characteristics with high shielding performance (SP) under misalignment conditions. The current strength and phase of the shielding system were determined by the current strength and mutual inductance of the wireless power transfer (WPT) and shielding coils. Additionally, we considered x and y misalignment conditions and analyzed SP and power transfer efficiency (PTE). The proposed method was verified through simulations and experiments in terms of SP and PTE. The experiments confirmed that, due to the shielding system control, SP increased from 49.22% to 61.74% under misalignment conditions, but there was no additional PTE reduction due to shielding coil control under these conditions.
«Han har da ei Lærebygning» Aasmund Olavsson Vinje sitt syn på Knud Knudsen i Dølen
Authors: Stykket Evy Beate
Published: February 2022

Knud Knudsen (1812–1895) and Aasmund O. Vinje (1818–1870) were two prominent Norwegian figures in the nineteenth century. Although they are both frequently mentioned in various books and texts about Norwegian language history, there are no studies focusing on a comparison of the two of them. They had strong opinions on various topics and often participated in public debates. In addition to this, they are intertwined with the early development of what later became the two Norwegian written languages: bokmål and nynorsk. Vinje is usually associated with what later became nynorsk, while Knudsen is a part of the history of bokmål. This dichotomy, however, obscures some of the details in the relationship between these two very complex men. The aim of this article is to share some nuances in the relationship between the two of them and to discuss their differences and similarities.
Цивилизационные и исторические аспекты современного каратэ
Authors: Lozovyi Anatolii , Serhіienko Volodymyr
Published: February 2022

Актуальность. В современном мире существует большое количество разнообразных боевых систем, стилей, школ и организаций, в той или иной степени связаных с каратэ, однако отсутствуют их систематизация и классификация, которая бы стала основой для разработки унифицированных программ неформального образования для современных форм каратэ. Цель и методы исследования. Цель исследования – систематизация ныне существующих форм каратэ на базе более глубокого и всестороннего определения изначальной сущности каждой из форм современного каратэ с использованием цивилизационно-исторического подхода, что включает: а) изучение влияния цивилизационных, исторических и социальных факторов как системо образующих для различных форм каратэ; б) сравнение исторических форм каратэ с точки зрения отнесения их к различным учебным секторам европейской академии EurEthICS ETSIA. В работе использована теория локальных цивилизаций применительно к предложенной ранее собственной классификации боевых систем. В результате исследования рассматривается современное каратэ в трех разных парадигмах: 1) Будзюцу – совокупность воинских умений; 2) Будо – японская система военизированного воспитания; 3) спорт – каратэ как спортивное единоборство, к которым могут быть отнесены пять исторических форм каратэ: Будзюцу; традиционные рю; стилевое (Будо) каратэ; генеральное каратэ; спортивное каратэ. Определяются принципиальные различия между ними, как основание для создания отдельных учебных программ. Выводы. Предложенная систематика может быть основой для универсальных программ обучения экспертов для каждой формы каратэ, а также валидации результатов неформального профессионального образования в соответствующих учебных секторах EurEthICS ETSIA.
Efficiency of Crossfit Exercises on The Level of Physical Fitness of Algerian High School Students
Authors: Hakim Hamzaoui , Mokhtar Mime , Abdelkader Benchehida , Lalia Cherara
Published: February 2022

The aim of this study was to assess the effectiveness of a CrossFit exercises over a period of 8 weeks in a group of high school students during their physical education sessions at the school and to mitigate the deficits in fitness caused by COVID-19 prevention measures. Stuff and Research Methods. 94 students aged 16–17 years were randomly allocated into an included 46 students (2nd level: 12 male and 11 female students; 3rd level: 12 male and 11 female students) and 1 control group included 48 students (2nd level: 13 male 11 female students; 3rd level: 13 male and 12 female students of experimental group (EG) that performed the 8 weeks CrossFit. During the study, students in the control group (CG) were based only on the general physical education and sports program for high school students in secondary school. Physical fitness tests were done: lifting straight legs in height (number times); running on the spot with an intensity of 70 % of the maximum to severe fatigue (c); shuttle run 4× m (with); 60 m run (s) and cross twine (cm). Results of the Research. Our conducted research shows the positive influence of the CrossFit. There are a considering changes, development of the maximum dynamic force endurance, speed abilities, flexibility and mobility in the hip joints of the main groups, In the age aspect, there is mainly the improvement in results with age, both in the main and control groups (p>0,05). Conclusions. The study achieved a significant improvement in the physical condition of the students, also allows to talk about the effectiveness of training, built on the basis of a motivated choice of the target CrossFit high school program.
Improving the Quality of Tilapia Fish Seeds (Oreochromis Niloticus) with Selection Methods in Mina Ayu Group of Tabanan Regency Bali Province
Authors: Suryani S.A.M.P. , Abdulah Faihana Ching , Faudzi Norfazreena Mohd , Sadguna D.N. , Arya I Wayan , Edi D.G.Semara , Pratama G.A Surya
Published: February 2022

Tilapia fish is much in demand because it has several advantages such as its distinctive taste that makes tilapia delicious after being processed in any way. Tilapia has the potential to be used as an export commodity in the form of fish fillets and the price is relatively cheap.  The climate situation and the extent of freshwater fishing land are contributing factors in the development of tilapia cultivation in Indonesia. One of the efforts to increase efficiency and productivity in cultivation is fish spawning activities. Spawning activities are important for producing seeds or larvae. Female fish are 300 to 400 g and for males, 400 to 500 g, aged 5 months. Tilapia can colonize weighing 250 g and age 4 to 6 months, meaning the parent used in this study has been following the required. The maintained parent is a healthy, unformed, and complete morphological parent (SNI 01-61412009). The purpose of this study is to improve the quality of Tilapia fish seeds produced by the Mina Ayu Group of Tabanan Regency of Bali Province by a selective breeding method.  Male and female tilapia broods are kept separately in hapa measuring 5x5x1m.  In shelters, for the acceleration of gonad maturation before the fish are stocked in the spawning pond. The feeding given during maintenance is 2 to 3%. Individual selection methods can improve the quality and survival rate of tilapia fish larvae. The absolute length increased 1.5 cm and weight increased 0.950 mg/day with a survival rate of 80% to 90%.