bluuebunny/crossref_metadata_2025 huggingface dataset:
The cytoplasmic structure hypothesis for ribosome assembly, vertical inheritance, and phylogeny
Authors: Thaler David S.
Published: May 2009

Fundamental questions in evolution concern deep divisions in the living world and verticalversushorizontal information transfer. Two contrasting views are: (i) three superkingdoms Archaea, Eubacteria, and Eukarya based on vertical inheritance of genes encoding ribosomes;versus(ii) a prokaryotic/eukaryotic dichotomy with unconstrained horizontal gene transfer (HGT) among prokaryotes. Vertical inheritance implies continuity of cytoplasmic and structural information whereas HGT transfers only DNA. By hypothesis, HGT of the translation machinery is constrained by interaction between new ribosomal gene products and vertically inherited cytoplasmic structure made largely of preexisting ribosomes. Ribosomes differentially enhance the assembly of new ribosomes made from closely related genes and inhibit the assembly of products from more distal genes. This hypothesis suggests experiments for synthetic biology: the ability of synthetic genomes to “boot,”i.e., establish hereditary continuity, will be constrained by the phylogenetic closeness of the cell “body” into which genomes are placed.
Omega‐3 polyunsaturated fatty acids and human health outcomes
Authors: Calder Philip C. , Yaqoob Parveen
Published: May 2009

Current intakes of very long chain ω‐3 fatty acids, eicosapentaenoic acid (EPA), and docosahexaenoic acid (DHA) are low in most individuals living in Western countries. A good natural source of these fatty acids is seafood, especially oily fish. Fish oil capsules contain these fatty acids too. Very long chain ω‐3 fatty acids are readily incorporated from capsules into transport, functional, and storage pools. This incorporation is dose‐dependent and follows a kinetic pattern that is characteristic for each pool. At sufficient levels of incorporation, EPA and DHA influence the physical nature of cell membranes and membrane protein‐mediated responses, eicosanoid generation, cell signaling and gene expression in many different cell types. Through these mechanisms, EPA and DHA influence cell and tissue physiology, and the way cells and tissues respond to external signals. In most cases, the effects seen are compatible with improvements in disease biomarker profiles or in health‐related outcomes. As a result, very long chain ω‐3 fatty acids play a role in achieving optimal health and in protection against disease. Long chain ω‐3 fatty acids protect against cardiovascular morbidity and mortality, and might be beneficial in rheumatoid arthritis, inflammatory bowel diseases, childhood learning, and behavior, and adult psychiatric and neurodegenerative illnesses. DHA has an important structural role in the eye and brain, and its supply early in life is known to be of vital importance. On the basis of the recognized health improvements brought about by long chain ω‐3 fatty acids, recommendations have been made to increase their intake. © 2009 International Union of Biochemistry and Molecular Biology, Inc.
The value of vitalism and Schrodinger's What is Life? in the contemporary classroom
Authors: Sitaraman Ramakrishnan
Published: May 2009

Classic experiments and novel ideas in the history of science are often mentioned in passing in contemporary college‐level science curricula. This study indicates that the detailed and creative recapitulation of a few well‐chosen and famous, if well‐known, results and ideas has the potential to increase students' understanding and appreciation of the scientific method and provides them with an altogether novel perspective of science. Since the students are usually aware of the salient facts involved, they are free to concentrate on the method, rather than worry about assimilating new facts. Such an approach has the potential to promote original thinking and rekindle enthusiasm for science, even at the university level.
Pulsatilla decoction and its active ingredients inhibit secretion of NO, ET‐1, TNF‐α, and IL‐1α in LPS‐induced rat intestinal microvascular endothelial cells
Authors: Hu Yiyi , Chen Xi , Duan Huiqin , Hu Yuanliang , Mu Xiang
Published: May 2009

To investigate the pharmacological mechanism of the traditional Chinese medicine, Pulsatilla decoction (PD), the levels of nitric oxide (NO), endothelin‐1 (ET‐1), tumor necrosis factor‐α (TNF‐α), and interleukin‐1α (IL‐1α) secreted by cultured rat intestinal microvascular endothelial cells (RIMECs) were determined after treatment with PD and its seven active ingredients, namely anemoside B4, anemonin, berberine, jatrorrhizine, palmatine, aesculin, and esculetin. RIMECs were challenged with lipopolysaccharide (LPS) at 1 µg ml−1 for 3 h and then treated with PD at 1, 5, and 10 mg ml−1 and its seven ingredients at 1, 5, and 10 µg ml−1 for 21 h, respectively. The results revealed that PD, anemonin, berberine, and esculetin inhibited the production of NO; PD, anemonin, and esculetin inhibited the secretion of ET‐1; PD, anemoside B4, berberine, jatrorrhizine, and aesculin downregulated TNF‐α expression; PD, anemoside B4, berberine, and palmatine decreased the content of IL‐1α. It showed that PD and its active ingredients could significantly inhibit the secretion of NO, ET‐1, TNF‐α, and IL‐1α in LPS‐induced RIMECs and suggested they would reduce inflammatory response via these cytokines. Copyright © 2009 John Wiley & Sons, Ltd.
Improvement of Yarrowia lipolytica Lipase Enantioselectivity by Using Mutagenesis Targeted to the Substrate Binding Site
Authors: Bordes F. , Cambon E. , Dossat‐Létisse V. , André I. , Croux C. , Nicaud J. M. , Marty A.
Published: June 2009

Enhanced enantioselectivity: The resolution of 2‐bromo‐arylacetic acid esters by Lip2p lipase from Yarrowia lipolytica was improved through mutagenesis of the substrate binding site. Position 232 was identified as crucial for the discrimination. Saturation of this position led to the identification of variant V232S, which has a tremendously increased activity and E value as compared to the parental enzyme.

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Lip2p lipase from Yarrowia lipolytica was shown to be an efficient catalyst for the resolution of 2‐bromo‐arylacetic acid esters, an important class of chemical intermediates in the pharmaceutical industry. Enantioselectivity of this lipase was improved by site‐directed mutagenesis targeted to the substrate binding site. To guide mutagenesis experiments, the three‐dimensional model of this lipase was built by homology modelling techniques by using the structures of lipases from Rhizomucor miehei and Thermomyces lanuginosa as templates. On the basis of this structural model, five amino acid residues (T88, V94, D97, V232, V285) that form the hydrophobic substrate binding site of the lipase were selected for site‐directed mutagenesis. Position 232 was identified as crucial for the discrimination between enantiomers. Variant V232A displayed an enantioselectivity enhanced by one order of magnitude, whereas variant V232L exhibited a selectivity inversion. To further explore the diversity, position 232 was systematically replaced by the 19 possible amino acids. Screening of this library led to the identification of the V232S variant, which has a tremendously increased E value compared to the parental enzyme for the resolution of 2‐bromo‐phenylacetic acid ethyl ester (58‐fold) and 2‐bromo‐o‐tolylacetic acid ethyl ester (16‐fold). In addition to the gain in enantioselectivity, a remarkable increase in velocity was observed (eightfold increase) for both substrates.
ChemInform Abstract: Room Temperature Ferromagnetism in Fe‐Doped BaSnO3.
Authors: Balamurugan K. , Kumar N. Harish , Chelvane J. Arout , Santhosh P. N.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Fe3O4 Nanoparticles at 100 °C and Its Magnetic Characterization.
Authors: Ozkaya Tevhide , Toprak Muhammet S. , Baykal Abdulhadi , Kavas Hueseyin , Koeseoglu Yueksel , Aktas Bekir
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric Michael Addition Mediated by Novel Cinchona Alkaloid‐Derived Bifunctional Catalysts Containing Sulfonamides.
Authors: Luo Jie , Xu Li‐Wen , Hay Robyn Aik Siew , Lu Yixin
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Facile, High Regio‐ and Chemoselective Conversion of Epoxides to β‐Chlorohydrins Using Chlorodiphenylphosphine under Solvent‐Free Conditions.
Authors: Aghapour Ghasem , Afzali Asieh , Salek Fahimeh
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Facile Method for the Preparation of MOM‐Protected Carbamates.
Authors: Barnes David M. , Barkalow Jufang , Plata Daniel J.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Aluminum Bases for the Highly Chemoselective Preparation of Aryl and Heteroaryl Aluminum Compounds.
Authors: Wunderlich Stefan H. , Knochel Paul
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iron‐Catalyzed Ligand‐Free Three‐Component Coupling Reactions of Aldehydes, Terminal Alkynes, and Amines.
Authors: Li Pinhua , Zhang Yicheng , Wang Lei
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: High ortho Preference in Ni‐Catalyzed Cross‐Coupling of Halophenols with Alkyl Grignard Reagents.
Authors: Wang Jia‐Rui , Manabe Kei
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Enantioselective Vinyl Additions of Vinylaluminum to Ketones Catalyzed by a Titanium(IV) Catalyst of (S)‐BINOL.
Authors: Biradar Deepak Baburao , Gau Han‐Mou
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Efficient Asymmetric Transfer Hydrogenation of Ketones Catalyzed by an Iron Complex Containing a P—N—N—P Tetradentate Ligand Formed by Template Synthesis.
Authors: Mikhailine Alexandre , Lough Alan J. , Morris Robert H.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ni(0)‐Catalyzed Conjugate Addition of Me3SiCN to Ynones: α‐Bromo‐β‐cyano Tetrasubstituted Enones.
Authors: Arai Takayoshi , Suemitsu Yuuki , Ikematsu Yui
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Organocatalytic Michael Addition of Malonates to α,β‐Unsaturated Ketones.
Authors: Li Pengfei , Wen Shigang , Yu Feng , Liu Qiaoxia , Li Wenjun , Wang Yongcan , Liang Xinmiao , Ye Jinxing
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Desulfurization of Thioamides into Amides with H2O2/ZrCl4 Reagent System.
Authors: Bahrami Kiumars , Khodaei Mohammad Mehdi , Tirandaz Yeganeh
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Plant Growth Regulatory Activity of o‐Nitrobenzoylthiourea Derivatives.
Authors: Lin Qi , Yao Hong , Wei Tai‐Bao , Zhang You‐Ming
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: ZrOCl2 Catalyzed Baeyer Condensation: A Facile and Efficient Synthesis of Triarylmethanes under Solvent‐Free Conditions.
Authors: Reddy Ch. Sanjeeva , Nagaraj A. , Srinivas A. , Reddy G. Purnachandra
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Praseodymium‐Induced Pinacol Formation.
Authors: Drapo Jeanette R. , Priefer Ronny
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ligand‐Free Silver(I)‐Catalyzed Intramolecular Friedel—Crafts Alkylation of Arenes with Allylic Alcohols.
Authors: Bandini Marco , Eichholzer Astrid , Kotrusz Peter , Tragni Michele , Troisi Stefano , Umani‐Ronchi Achille
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ring Contraction of 1,2‐Dihydronaphthalenes Promoted by Thallium(III) in Acetonitrile: A Diastereoselective Approach to Indans.
Authors: Ferraz Helena M. C. , Carneiro Vania M. T. , Silva Luiz F. Jr.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 3‐Aryltetronic Acids: Efficient Preparation and Use as Precursors for Vulpinic Acids.
Authors: Mallinger Aurelia , Le Gall Thierry , Mioskowski Charles
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Benzofurans as Efficient Dienophiles in Normal Electron Demand [4 + 2] Cycloadditions.
Authors: Chopin Nathalie , Gerard Helene , Chataigner Isabelle , Piettre Serge R.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: An Efficient Synthesis of Raloxifene (VIII) in Ionic Liquid: A Green Approach.
Authors: Shinde Pravin S. , Shinde Sandip S. , Renge Atul S. , Patil Gajanan H. , Rode Ambadas B. , Pawar Rajendra R.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Zirconium‐Catalyzed Friedel—Crafts Alkylation of Pyrrole with Trifluoromethyl Ketones.
Authors: Blay Gonzalo , Fernandez Isabel , Monleon Alicia , Pedro Jose R. , Vila Carlos
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Base Catalyzed Intramolecular Cyclization of Dialkylcrotyl(3‐alkenylpropyn‐2‐yl)ammonium Salts and Aqueous Base Fission of 2,2‐Dialkyl‐4‐methyl‐ and 2,2‐Dialkyl‐4,6‐dimethyl‐2,6,7,7a‐tetrahydro‐1H‐isoindolium Bromides.
Authors: Chukhajian E. O. , Nalbandyan M. K. , Gevorkyan A. R. , Shakhatuni K. G. , Panosyan G. A.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Conceptually New Approach to the Asymmetric Synthesis of 3‐Aryl and Alkyl Poly‐Substituted Isoindolinones.
Authors: Deniau Eric , Couture Axel , Grandclaudon Pierre
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Antimicrobial Activities os Some N‐{4‐[5‐Aryl‐1‐(isonicotinoyl)pyrazol‐3‐yl]‐phenyl}‐benzenesulfonamide and 3‐(4‐Benzenesulfonylaminophenyl)‐5‐aryl‐pyrazole‐1‐carboxylic Acid Amide.
Authors: Jamode V. S. , Chandak H. S. , Bhagat P. R.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Short and Efficient Synthesis of the Selective H4 Receptor Agonist 4‐Methylhistamine.
Authors: Rivara Mirko , Zuliani Valentina , Plazzi Pier V. , Bordi Fabrizio
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Copper‐Facilitated Suzuki Reactions: Application to 2‐Heterocyclic Boronates.
Authors: Deng James Z. , Paone Daniel V. , Ginnetti Anthony T. , Kurihara Hideki , Dreher Spencer D. , Weissman Steven A. , Stauffer Shaun R. , Burgey Christopher S.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 4‐Hydroxy‐3‐formylideneamno‐1H/methyl/phenylquinolin‐2‐ones.
Authors: Bhudevi B. , Ramana P. Venkata , Mudiraj Anwita , Reddy A. Ram
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: 4‐Hydroxy‐2‐quinolones. Part 145. p‐Toluenesulfonylhydrazide as a Tosylating Agent.
Authors: Ukrainets I. V. , Tkach A. A. , Kravtsova V. V. , Shishkina S. V.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Schiff′s Bases of 8‐Methyltetrazolo[1,5‐a]quinoline as Potential Antiinflammatory and Antimicrobial Agents.
Authors: Bawa Sandhya , Kumar Suresh
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of 2,3‐Disubstituted Derivatives of Pyrano‐, Thiopyrano‐, and Benzoanellated Pyrido[2,3‐b]thieno[3,2‐d]pyrimidines.
Authors: Paronikian E. G. , Akopian Sh. F. , Noravian A. S.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Interaction of 2‐Piperazinobenzaldehyde with Cyanoacet(thio)amide: Stereoselective Cyclization by the “tert‐Amino Effect” Mechanism.
Authors: Glukharev T. V. , Klimova E. P. , Platonova A. Yu. , Morzherin Yu. Yu.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Bromoethylsulfonium Salt — A More Effective Annulation Agent for the Synthesis of 6‐ and 7‐Membered 1,4‐Heterocyclic Compounds.
Authors: Yar Muhammad , McGarrigle Eoghan M. , Aggarwal Varinder K.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Binding Properties of Two New Fluorescent Molecular Clips Based on Diethoxycarbonyl Glycoluril.
Authors: Hu Sheng‐Li , Wang Shuai , Li Yi‐Tao , Cao Li‐Ping , Wu An‐Xin
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemistry of the Pseudobasic Amino Alcohols. Part 40. Synthesis of Three New Condensed Nitrogen Heterocyclic Systems.
Authors: Korbonits Dezso , Podanyi Benjamin , Illar Arpad , Simon Kalman , Hanusz Miklos , Hermecz Istvan
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Three Component Mannich Reaction and 1,5‐Benzodiazepine Synthesis Catalyzed by a Tetranitrile‐Silver Complex.
Authors: Krishnan Gopalakrishnapanicker Rajesh , Sreerekha Radhakrishnan , Sreekumar Krishnapillai
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Spectral Characteristics of 2‐Aryl‐6‐methyl‐ and 2‐Aryl‐6‐benzyl‐4,8a‐diphenylperhydro[1,3,2]dioxaborinino [5,4‐c]pyridines.
Authors: Anh Le Tuan , Polyanskiy K. B. , Mamyrbekova J. A. , Soldatenkov A. T. , Soldatova S. A. , Kurilkin V. V. , Terentiev P. B.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Copper‐Catalyzed Enantioselective β‐Boration of Acyclic Enones.
Authors: Sim Hak‐Suk , Feng Xinhui , Yun Jaesook
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Formation and Utility of Azasilacyclopentadienes Derived from Silacyclopropenes and Nitriles.
Authors: Anderson Laura L. , Woerpel K. A.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Total Synthesis and Structure Elucidation of (+)‐Phorbasin C.
Authors: Macklin Todd K. , Micalizio Glenn C.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A New Depsidone from Usnea diffracta
Authors: Qi Huan Yang , Jin Yuan Peng , Shi Yan Ping
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Macrolactin S (I), a New Antibacterial Agent with FabG‐Inhibitory Activity from Bacillus sp. AT28.
Authors: Sohn Mi‐Jin , Zheng Chang‐Ji , Kim Won‐Gon
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Biosynthetic Capacities of Actinomycetes. Part 47. Nataxazole (I), a New Benzoxazole Derivative with Antitumor Activity Produced by Streptomyces sp. Tue 6176.
Authors: Sommer Patricia S. M. , Almeida Rosemary C. , Schneider Kathrin , Beil Winfried , Suessmuth Roderich D. , Fiedler Hans‐Peter
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Addition of Zr—O—B Compounds to Improve the Performances of Alumina Matrix Ceramic Materials
Authors: Li Bin , Deng Jianxin
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structural Effects in Molecular Metal Halides
Authors: Hargittai Magdolna
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Production of Unnatural Bioactive Glycosides Using Plant Secondary Product Glycosyltransferases
Authors: Masada Sayaka , Mizukami Hajime
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Lycopodium Alkaloids
Authors: Hirasawa Yusuke , Kobayashi Jun'ichi , Morita Hiroshi
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rhodium(I)‐Catalyzed Enantioselective C—C Bond Activation.
Authors: Winter Christian , Krause Norbert
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Metal‐Catalyzed Halogen Exchange Reactions of Aryl Halides
Authors: Sheppard Tom D.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pentafluorobenzaldehyde and Its Utilizing in Organic Synthesis
Authors: Pazitny Andrej , Solcan Tomas , Vegh Daniel
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Primaquine Revisited Six Decades After Its Discovery
Authors: Vale Nuno , Moreira Rui , Gomes Paula
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Development of Aqueous Metathesis Catalysts
Authors: Zaman Shazia , Curnow Owen J. , Abell Andrew D.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recent Synthetic Developments in a Powerful Imino Diels—Alder Reaction (Povarov Reaction): Application to the Synthesis of N‐Polyheterocycles and Related Alkaloids.
Authors: Kouznetsov Vladimir V.
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Metabolites from Symbiotic Bacteria
Authors: Piel Joern
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Perspectives on the Current State of Pharmacogenomics in Drug Development
Authors: Tamaoki Mieko
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Time‐Resolved Chromatographic Analysis and Mechanisms in Adsorption and Catalysis
Authors: Roubani‐Kalantzopoulou Fani
Published: May 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Abbau von Methyl‐tert‐butylether in einem hydrodynamischen Kavitationsfeld
Authors: Schmid A.
Published: June 2009

Mittels hydrodynamisch erzeugter Kavitation in einer Düsenströmung lässt sich ein implodierendes Kavitationsfeld erzeugen, in dem diverse Inhaltsstoffe durch Radikalreaktionen chemisch modifiziert und schließlich bis zu CO2 und H2O oxidiert werden. Durch geeignete Wahl der Düse in Kombination mit geringen Umgebungsdrücken lässt sich das Kavitationsfeld über eine Wegstrecke von mehreren Metern aufrecht erhalten. Diese Technologie überwindet die derzeit vorliegenden Beschränkungen bei der Generierung von Kavitation durch Ultraschall, bei der sich nur in der Nähe der Sonotroden die notwendige Kavitationswolke bildet [1] und somit auf einen relativ kleinen Einwirkraum beschränkt. Während der Pilotversuche konnten sowohl Methyl‐tert‐butylether (MTBE) als auch Ethyl‐tert‐butylether (ETBE) unter Einwirkung von Kavitation signifikant ohne Zusatz von Chemikalien in nicht näher bekannte Intermediärprodukte abgebaut werden. Nach ca. 30 Minuten Einwirkdauer nimmt schließlich auch die CSB‐Konzentration ab; ein Indiz für die vollständige Mineralisierung der Ausgangsstoffe. In dem präsentierten Konzentrationsbereich von ca. 30 ppm liegt der spezifische Energiebedarf für den Abbau von MTBE in einem Bereich von ca. 200 Wh/ppm.
Cytoplasmic Ig‐domain proteins: Cytoskeletal regulators with a role in human disease
Authors: Otey Carol A. , Dixon Richard , Stack Christianna , Goicoechea Silvia M.
Published: May 2009

Immunoglobulin domains are found in a wide variety of functionally diverse transmembrane proteins, and also in a smaller number of cytoplasmic proteins. Members of this latter group are usually associated with the actin cytoskeleton, and most of them bind directly to either actin or myosin, or both. Recently, studies of inherited human disorders have identified disease‐causing mutations in five cytoplasmic Ig‐domain proteins: myosin‐binding protein C, titin, myotilin, palladin, and myopalladin. Together with results obtained from cultured cells and mouse models, these clinical studies have yielded novel insights into the unexpected roles of Ig domain proteins in mechanotransduction and signaling to the nucleus. An emerging theme in this field is that cytoskeleton‐associated Ig domain proteins are more than structural elements of the cell, and may have evolved to fill different needs in different cellular compartments. Cell Motil. Cytoskeleton 2009. © 2009 Wiley‐Liss, Inc.
Polynuclear Complexes of Macrocyclic Oxamide with Thiocyanate: Syntheses, Crystal Structures and Magnetic Properties
Authors: Sun Ya‐Qiu , Gao Dong‐Zhao , Dong Wen , Liao Dai‐Zheng , Zhang Chen‐Xi
Published: May 2009

Five complexes with the formula {[(CuL)2Cr(μ‐SCN)2]OH}n (1), [Mn(CuL)2(NCS)2] (2), [Cu(CuL)2(NCS)2] (3), [Ni(CuL)2(NCS)2] (4) and [Co(CuL)(NCS)2(CH3OH)2]2 (5), (H2L = 2,3‐dioxo‐5,6,14,15‐dibenzo‐1,4,8,12‐tetraazacyclopentadeca‐7,13‐diene) were synthesized and structurally determined. The structure of 1 has oxamido‐bridged trinuclear [CrIIICuII2] units and consists of a 1D helical chain formed by the linking of copper(II) and chromium(III) ions through the oxamido and μ1,3‐NCS bridges. The structure of 2, 3 or 4 consists of oxamido‐bridged trinuclear [MIIICuII2] molecules (for 2–4, M = Mn, Cu, Ni, respectively) and arranges in a 1D zig‐zag chain. Complex 5 is a composed of a tetranuclear [CoII2CuII2] molecule with both the oxamido and μ1,3‐NCS bridges. The variable‐temperature magnetic susceptibility measurements (2–300K) of 1, 2, 4 and 5 show pronounced antiferromagnetic interactions between the copper(II) atom and neighbouring metal ions.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
“Frustration” of Orbital Interactions in Lewis Base/Lewis Acid Adducts: A Computational Study of H2 Uptake by Phosphanylboranes R2P=BR′2
Authors: Nyhlén Jonas , Privalov Timofei
Published: May 2009

The reaction of molecular hydrogen with phosphanylboranes R2P=BR′2 (1) is systematically studied by means of density functional theory calculations and second order Møller‐Plesset perturbation theory. The potential energy barriers and the exothermicity of H2 uptake are reported for a series of phosphanylboranes with different electron‐donating and ‐withdrawing groups bound to phosphorus and boron. Systematic molecular orbital analysis reveals that the “frustration” between boron and phosphorus can be increased by modifying the substituents, and thus, atomic orbital interactions could be exploited in order to increase the reactivity of 1. Additionally, we found a correlation between the potential energy barrier for H2 uptake and the energy of the HOMO of the P=B complex, which could be relevant for the prediction of the properties of candidate compounds for H2 activation and therefore useful for the development of such systems. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
Abnormal Hepatic Energy Homeostasis in Type 2 Diabetes†
Authors: Szendroedi Julia , Chmelik Marek , Schmid Albrecht Ingo , Nowotny Peter , Brehm Attila , Krssak Martin , Moser Ewald , Roden Michael
Published: May 2009

Increased hepatocellular lipids relate to insulin resistance and are typical for individuals with type 2 diabetes mellitus (T2DM). Steatosis and T2DM have been further associated with impaired muscular adenosine triphosphate (ATP) turnover indicating reduced mitochondrial fitness. Thus, we tested the hypothesis that hepatic energy metabolism could be impaired even in metabolically well-controlled T2DM. We measured hepatic lipid volume fraction (HLVF) and absolute concentrations of γATP, inorganic phosphate (Pi), phosphomonoesters and phosphodiesters using noninvasive 1H/ 31P magnetic resonance spectroscopy in individuals with T2DM (58 ± 6 years, 27 ± 3 kg/m 2), and age-matched and body mass index–matched (mCON; 61 ± 4 years, 26 ± 4 kg/m 2) and young lean humans (yCON; 25 ± 3 years, 22 ± 2 kg/m 2,

P

< 0.005,

P

< 0.05 versus T2DM and mCON). Insulin-mediated whole-body glucose disposal (M) and endogenous glucose production (iEGP) were assessed during euglycemic-hyperinsulinemic clamps. Individuals with T2DM had 26% and 23% lower γATP (1.68 ± 0.11; 2.26 ± 0.20; 2.20 ± 0.09 mmol/L;

P

< 0.05) than mCON and yCON individuals, respectively. Further, they had 28% and 31% lower Pi than did individuals from the mCON and yCON groups (0.96 ± 0.06; 1.33 ± 0.13; 1.41 ± 0.07 mmol/L;

P

< 0.05). Phosphomonoesters, phosphodiesters, and liver aminotransferases did not differ between groups. HLVF was not different between those from the T2DM and mCON groups, but higher (

P

= 0.002) than in those from the yCON group. T2DM had 13-fold higher iEGP than mCON (

P

< 0.05). Even after adjustment for HLVF, hepatic ATP and Pi related negatively to hepatic insulin sensitivity (iEGP) (r =-0.665,

P

= 0.010, r =-0.680,

P

= 0.007) but not to whole-body insulin sensitivity.

Conclusion:

These data suggest that impaired hepatic energy metabolism and insulin resistance could precede the development of steatosis in individuals with T2DM. (Hepatology 2009.)
Appearance and incomplete label matching for diffeomorphic template based hippocampus segmentation
Authors: Pluta John , Avants Brian B. , Glynn Simon , Awate Suyash , Gee James C. , Detre John A.
Published: May 2009

We present a robust, high‐throughput, semiautomated template‐based protocol for segmenting the hippocampus in temporal lobe epilepsy. The semiautomated component of this approach, which minimizes user effort while maximizing the benefit of human input to the algorithm, relies on “incomplete labeling.” Incomplete labeling requires the user to quickly and approximately segment a few key regions of the hippocampus through a user‐interface. Subsequently, this partial labeling of the hippocampus is combined with image similarity terms to guide volumetric diffeomorphic normalization between an individual brain and an unbiased disease‐specific template, with fully labeled hippocampi. We solve this many‐to‐few and few‐to‐many matching problem, and gain robustness to inter and intrarater variability and small errors in user labeling, by embedding the template‐based normalization within a probabilistic framework that examines both label geometry and appearance data at each label. We evaluate the reliability of this framework with respect to manual labeling and show that it increases minimum performance levels relative to fully automated approaches and provides high inter‐rater reliability. Thus, this approach does not require expert neuroanatomical training and is viable for high‐throughput studies of both the normal and the highly atrophic hippocampus. © 2009 Wiley‐Liss, Inc.
A study on the factors affecting the stable isotopic composition in precipitation of Tamil Nadu, India
Authors: Chidambaram S. , Prasanna M. V. , Ramanathan A. L. , Vasu K. , Hameed S. , Warrier U. K , Srinivasamoorthy K. , Manivannan R. , Tirumalesh K. , Anandhan P. , Johnsonbabu G.
Published: May 2009

Stable isotope measurements in precipitation help us to form the basic inference about the origin and the state of water in different environments. The precipitation samples collected during the South West Monsoon (SWM) during August 2007 from 37 different locations in the state help in deriving the first preliminary local meteoric water line (LMWL) for the Tamil Nadu State. The study reveals that there are three main sources of water vapours, namely South East Arabian Sea (SEAS), Indian Ocean (IO) and evaporation from local water bodies. There are wide variations in the altitude and amount of rainfall received in the state. It is also noted that there is a significant variation in the latitude and the distance from the coast. Hence, an attempt is made in this paper to study the factors controlling the composition of stable isotopes in precipitation with reference to amount of rainfall, latitude, altitude and the continental effect. The altitude and continental effect shows good correlation to the variations in stable isotope composition. Copyright © 2009 John Wiley & Sons, Ltd.
Impact of dam operations on hyporheic exchange in the riparian zone of a regulated river
Authors: Hucks Sawyer Audrey , Bayani Cardenas M. , Bomar Ashleigh , Mackey Meredith
Published: May 2009

Dam operations commonly cause large, frequent fluctuations in river stage, which persist for long distances downstream. The stage fluctuations force river water into and out of the banks, defining lateral hyporheic exchange paths. To evaluate the penetration distance and rates of dam‐induced hyporheic exchange, we monitored water‐table elevation, temperature, and specific conductivity along a transect perpendicular to the Colorado River (Austin, Texas, USA), 15 km downstream of the Longhorn dam. Stage fluctuates daily by almost a metre. The daily hyporheic exchange volume per metre of bank is 1·0 m3. Dam‐induced hyporheic exchange penetrates several metres into the riparian aquifer, while water‐table fluctuations propagate 30 m into the riparian aquifer. Water chemistry and temperature fluctuate near the channel in response to the flow oscillations. In the absence of dam operations, groundwater would flow steadily through the riparian aquifer towards the river, laterally limiting hyporheic exchange and stabilizing temperatures and water chemistry near the channel. Therefore, dam operations fundamentally change the hydrological, thermal, and geochemical dynamics of riparian aquifers and their hyporheic zones. Copyright © 2009 John Wiley & Sons, Ltd.