bluuebunny/crossref_metadata_2025 huggingface dataset:
Mucin2 and Lipid Profile Estimation in Giardia Lamblia Infected Patients: A Case-control Study
Authors:   Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Kufa, Najaf, Iraq, Hassan Ekhlas Sabah
Published: October 2022

Introduction: Globally, Giardia duodenalis (G. lamblia) is a protozoan parasite that has the ability to cause sporadic or epidemic infectious diarrhoea. Giardia infection is a crucial cause of waterborne and foodborne disease, outbreaks in the daycare centre, and international travel-related infection. This study aimed to evaluate the effects of Giardia lamblia infection on serum MUC2 and lipid profile. Patients and Methods: From March to April 2021, a case-control study was conducted on 48 patients with giardiasis who attended AL-Hakeem Hospital in Najaf Province in Iraq and 24 healthy adults as a control group. Stool examinations were done using standard techniques for the identification of the parasitic infection. Results: The results showed a significantly higher concentration (130.57 ± 4.04 ng/ml, and 130.11 ± 3.6 ng/ml) (p < 0.05 of MUC2 in G. lamblia infected patients (males and females) in comparison to the individuals of the control group. In addition, significantly higher concentrations (p < 0.05) of cholesterol, VLDL, TG, and LDL were found in comparison to the control individuals, whereas the concentration of HDL was significantly lower (p < 0.05 in patients infected with G. lamblia as compared to the control group. Conclusion: The current study revealed that MUC2 and lipid profile are valuable biomarkers that help in the diagnosis of G. lamblia parasite infection.
Parental Stress in Managing School-going Children during the COVID-19 Lockdown Period - A Pilot Study
Authors:   Professor, Department of Pediatrics, Chettinad Academy of  Research & Education (CARE), Chettinad Hospital & Research Institute (CHRI), Kelambakkam, Tamil Nadu, India, Jenifer Antony
Published: October 2022

Introduction: Parental stress has various reasons like low income, broken family, and lesser family or social support. COVID-19 and the lockdown that has been imposed have created stress among the people. This may be due to increased financial instability within the family, illness or exposure to COVID-19 itself. This study is done to assess the stress on parents in managing their school-going children. Aim: To assess the stress on parents in managing school-going children with their online classes and the factors which are concerning for the parents during the lockdown period. Materials and Method: Parents of children between the age group of 5-12 years were included in the study. These parents’ stress level was analysed based on their response to the parental stress scale. Results: The stress level is found to be on the higher side in the case of a single parent working with the mean stress level being 42.6 when compared to both parents working which had a mean stress level of 32.6. Other factors which are found to increase the stress among parents were low socioeconomic status, having children of a younger age group, and parents living in nuclear families. Conclusion: During the COVID-19 lockdown, the mental health of the parents was found to be influenced by various causes. Good family support, better work timing of parents, and a routine help in reducing stress in the family.
Risk Factors associated with Leprosy and its Disability in Araria, A High Endemic District of India
Authors:   PhD Scholar, USM & PMHS, GGSIPU & Ex. National Consultant (Public Health), DGHS, MoHFW, Delhi, India., Karotia Deepika
Published: October 2022

Background: Despite the achievement of elimination of leprosy in 2005 at the national level, India still has more than a dozen states reporting a Grade II Disability (G2D) rate of > 2 per million populations, and over two-fifth of districts are high or moderate endemic. It is necessary to understand the factors leading to continued endemicity and disability in these districts to plan strategies and achieve the envisaged targets of NLEP. Method: To identify individual, environmental, socio-demographic, and health system-related factors responsible for leprosy and disability occurrence in a high endemic district of Bihar, case-control design was adopted. A total of 896 individuals (448 cases and 448 controls - excluding family members; matched with age and gender) were interviewed with pre-designed, pre-tested schedules. Blocks were stratified based on the proportion of G2D among new cases detected (NCD) in the year 2019 to draw samples in proportion to NCD. Descriptive, stratified, bivariate and multinomial logistic regression was done to find the association among factors. Results: Factors found significant for leprosy occurrence were Scheduled Caste (SC) category, education less than 8th class, unemployment, living in the household without windows/ light/ safe water supply, kutcha type, family income less than INR 8000, and history of leprosy patients in family/ friends. Further age more than 14 years, ST category, reporting delay of 6-12 months, remoteness of health facility, financial constraints etc. were found significant for disability occurrence. Conclusion: Further exploration in this area and designing strategies considering these factors may help in controlling this chronic disease in endemic areas and preventing related disability.
Exploring Squalene and Rhodoxanthin from Hylocereus undatus as a Therapeutic Agent for the Treatment of Human Liver Cancer using Docking Analysis
Authors:   Associate Professor, Department of Zoology, Presidency College, Chennai, India, K Sivakumari
Published: October 2022

Introduction: The dragon fruit H. undatus contains several active phyto-compounds, which act as good antioxidant, anti-inflammatory, and anti-cancer agents. To explore the apoptotic potential of these phyto-compounds, it would be apt to screen the interaction of these compounds with apoptotic proteins via., in silico docking studies. Method: The current study was planned to evaluate the docking interaction of selected GC-MS spectrum components from H. undatus(squalene and rhodoxanthin) with apoptotic proteins (AIF, Apaf-1, BAK, caspase 8, and RIP) by PatchDock docking algorithm. Results: The docking interaction showed that rhodoxanthin docks well with apoptotic proteins, and rhodoxanthin is recommended by the Lipinski rule as the best treatment for liver cancer. Conclusion: The application of rhodoxanthin as a potential and natural therapeutic agent to cure diseases is validated by docking results.
‘No poverty’ - sustainable development goals in the light of Polish statistics and social policy activities
Authors: Palimąka Karolina , Karaś Gabriela
Published: October 2022

The purpose of this research is to examine the poverty phenomenon indicators in Poland through the prism of sustainable development. The subject of poverty and its consequences is often omitted in the discussion of sustainable development, or simplified only to social issues, yet it is an important aspect of economic development and implementation of Sustainable Development Goals (SDGs). The study will cover the problem of poverty in Poland, together with the assessment of the potential of implementation of sustainable development goals in terms of poverty eradication, as well as the issue of the impact of social policy activities on SDGs (named as ‘no poverty’) and household finances, both closely related to the risk of poverty. To achieve the aim of the study the authors use statistical data describing the issues of poverty and changes in this area in the period between 2010 and 2020 (or the most up-to-date data available) based on data from the Central Statistical Office in Poland.
Lex Constructionis as a Regulator of an International Construction Contract in Russia
Authors: Kirsanov A. N. , Korablin A. V.
Published: October 2022

Introduction. The gaps in the international private legal regulation of legal relations arising from an international construction contract are filled by other sources of law, primarily Lex constructionis, which is a set of acts and documents developed by non-governmental organizations that do not have the force of law, but are actively used in business circulation.

FIDIC contracts can be cited as standard contracts, which are a set of narrowly focused standard forms of contracts, each of which was developed for a specific situation and certain legal relations arising from an international construction contract.

Despite the international and narrowly focused nature of the FIDIC agreements, their application is also possible in the national projects of Russia with some reservations.

The purpose of this article is to analyze Lex constructionis on the example of standard FIDIC con- tracts and the possibility of using FIDIC contracts in national projects in Russia.

Materials and methods. The implementation of the research tasks was achieved on the basis of the study of theoretical and practical experience in the application of standard FIDIC construction contracts. The methodological basis of the study was the following methods: generalization, analysis, synthesis, induction, deduction, comparative legal analysis. The results of the study. The following tasks are solved in the work: an analysis of standard contracts and Russian legislation is carried out, their contradictions are revealed.

Discussion and conclusions. The use of FIDIC model contracts without their adaptation to Russian law is not possible due to the existence of contradictions between the provisions of FIDIC model contracts and the mandatory rules of Russian law, arising from different approaches to the regulation of a construction contract - FIDIC model contracts are based on the doctrine of common law, while Russian law belongs to the Romano-Germanic legal family.
Defense of Rights and Interests of Participants of Remote Investment Transactions
Authors: Matytsin D. E.
Published: October 2022

Introduction. Article is devoted to protection and defense of rights and legitimate interests of participants of remote investment transactions. It is noted that the Federal Law №69-FZ «On Protection and Encouragement of Capital Investments in the Russian Federation» in fact does not regulate any protection of investments but only those based on a special agreement. As for the content of this agreement, proceeding from the provisions of Articles 9-10 of this Federal Law, it also regulates only some particular aspects of protection of investments. Consideration of protection in general by analogy with the institute of judicial protection allows us to conclude that we are talking about a special law-enforcement activity, as a rule, law enforcement and carried out on a procedural basis (exception - self-protection of civil rights) for the purpose of individualized restoration of violated rights and legitimate interests of participants of civil legal relations. It can be represented as a complex system consisting of three levels: general guarantees of protection, provided to all subjects of civil relations at the legislative level; special measures of legal protection, fixed for the participants of investment activity; methods of protection, typical for certain types of investment transactions depending on the type of investment, their scale (intranational or international), forms of commission, etc.

Materials and methods. The methodological basis of this study was the methods of scientific cognition, among which the main place is occupied by the methods of consistency, analysis and comparative law.

The results of the study. As a result of the analysis, it was revealed that the consideration of protection in general, by analogy with the institute of judicial protection, allows us to conclude that we are talking about a special law enforcement activity, as a rule, law enforcement and carried out on a procedural basis (exception – self-defense of civil rights) for the purpose of individualized restoration of violated rights and legitimate interests of participants in civil legal relations, and as for the protection of rights, unlike protection, it admits a generalized nature and combines all regulatory measures aimed at ensuring the relevant rights and interests.

Discussion and conclusion. The prerequisites of the peculiarities of protecting the rights and interests of participants in remote investment transactions are revealed, which are primarily due to the form of their commission, which affects the content and generates some relatively new legal effects; their main advantages and disadvantages are analyzed. It is concluded that the main problem of protecting the rights and interests of participants in remote investment transactions is the ratio of traditional and innovative legal instruments of such protection, as well as a combination of general legal guarantees and special ones characteristic of investment relations of this type.
MENENTUKAN TINGKAT KELONGSORAN TANAH DENGAN METODE KUAT GESER LANGSUNG
Authors: Al hasbi Muhammad Nasih , Candra Agata Iwan , Wibowo Mohamad Agus Fajar , Heru Rahmat , Rivianto Arif
Published: October 2022

Tanah dapat dibedakan menurut ukuran partikel yaitu : lempung berlumpur, pasir, tanah liat. Tanah liat atau lempung berpasir adalah tanah yang memiliki agregar berbutir halus. Tanah lempung berpasir memiliki keunggulan seperti mudah menyerap air, memiliki permeabilitas yang cukup efektif. Selain itu tanah lempung memiliki kekurangan seperti tanahnya jika dibentuk mudah pecah, didalamnya memiliki nutrisi yang rendah, kurang cocok untuk bercocok tanam. Dalam perencanaan bangunan, tanah mempunyai peran penting karena sebagai kekuatan konstruksi dasar bangunan, seperti pada pembangunan jalan raya, jembatan, dan banguanan bertingkat. Tujuan penelitian ini adalah agar peneliti mampu mengetahui seberapa kuat dan stabilnya suatu tanah tersebut sebelum mendirikan sebuah bangunan pada daerah yang sudah ditentukan. Metode yang digunakan adalah kuat geser tanah menggunakan alat Direct Test Shear. Hasil dari penelitian kuat geser tanah yang telah dilakukan, kita didapat memperoleh kohesi sebesar 0,267 kPa dan nilai dari sudut geser sebesar 1,4800, sehingga dari data yang diperoleh bahwa tanah tersebut rawan longsor dan memerlukan perbaikan tanah agar tanah kuat menopang pondasi bangunan.
Pedagogiset pakopelit tiedonhankinnan opetuksessa
Authors: Koiranen Joona
Published: October 2022

Metropolia Ammattikorkeakoulun kirjasto testasi pedagogisen pakopelin käyttöä tiedonhankinnan opetuksessa 2019–2020. Oppimistulokset olivat rohkaisevia.
Avoimen tieteen koulutukset avoimena – Mikä muuttui?
Authors: Laakso Kati , Sunikka Anne , Försgård Charlotte
Published: October 2022

Avoimen tieteen ja tutkimusdatanhallinnan koulutusten järjes-täminen alkaa olla vakiintunut käytäntö yliopistoissa, ammat-tikorkeakouluissa ja tutkimuslaitoksissa. Koulutukset tarjotaan tavallisimmin oman organisaation henkilöille. Aalto-yliopiston datatukitiimi päätti kokeilla syksyllä 2021, mikä muuttuu – vai muuttuuko mikään – kun koulutukset avataan ilman rajoituksia sekä kotimaisille että ulkomaisille organisaatioille. Ilmoittautuneista yli puolet tuli suomalaisista yliopistoista ja ammattikorkeakouluista. Noin neljännes osallistujista oli aaltolaisia. Koulutukseen oltiin pääasiassa tyytyväisiä, joskin lisää käytännönläheisyyttä kaivattiin.
Esittelyssä Kansalliskirjaston uusi ylikirjastonhoitaja Kimmo Tuominen
Authors: Vahtola Aija
Published: October 2022

Helsingin yliopiston rehtori on nimittänyt Kimmo Tuomisen Kan-salliskirjaston ylikirjastonhoitajan tehtävään. Edellinen ylikirjastonhoitaja Cecilia af Forselles jäi eläkkeelle 1. 7. 2022. Yhteiskuntatieteiden tohtori Kimmo Tuomisella on laaja kokemus kirjastoalalta ja alan luottamustehtävistä.
BIST Sektör Endekslerinin Zamanla Değişen Beta Katsayıları
Authors: USTAOĞLU Erkan
Published: October 2022

Çalışmanın amacı BIST’te yer alan 21 adet sektör endeksinin zamanla değişen beta katsayılarının hesaplanmasıdır. Analizler sonucunda 21 adet sektör endeksinin beta katsayılarının zamanla değişen bir yapıda olduğu gözlenmiştir. Aynı zamanda zamanla değişen tüm sektör betalarının ortalamaya dönme eğilimde olduğu belirlenmiştir. Çalışmada en oynak beta katsayı XFINK endeksine ait iken, en az oynak beta katsayısı XSPOR endeksine ait olduğu tespit edilmiştir. Ayrıca çalışmada ortalama olarak en düşük beta katsayısı 0.490 ile XSPOR endeksine ait iken en yüksek beta katsayısı ise 1.248 ile XBANK endeksine ait olduğu saptanmıştır. Çalışmada, sektör endekslerinin betası zamanla benzer değişimlere sahip olduğu tespit edilmiştir.
What Drives Consumer Purchase Intention on Products Offered by E- Commerce During the Covid-19 Pandemic? An Empirical Study at Tokopedia
Authors: Purba Parlin , Setiyaningrum Ari
Published: October 2022

The main purpose of this research is to test a model to prove whether perceived usefulness, perceived ease of use, cost saving and time saving affect purchase intention directly or indirectly through perceived customer value. The research model was tested in e-commerce contexts at Tokopedia during the Covid-19 pandemic. Primary data were collected by distributing questionnaires to 313 people who had visited Tokopedia website or application but have never made a purchase. The purposive sampling technique is used in this research. Data analyzed using the partial least square method with SmartPLS. The findings indicated that perceived ease of use affects purchase intention, whereas perceived usefulness, cost saving, and time saving do not affect purchase intention. The results of the indirect effect prove perceived customer value mediates the effect of cost saving and time saving on purchase intention, while perceived customer value does not mediate the effect of perceived usefulness and perceived ease of use on purchase intention. The research findings also show that cost saving and time saving affect perceived customer value, whereas perceived usefulness and perceived ease of use do not affect perceived customer value, and perceived customer value affects purchase intention.
Keywords— perceived usefulness; perceived ease of use; cost saving; time saving; perceived customer value; purchase intention.
موقف رئيس لجنة البلقان البريطانية نويل باكستون من الوجود العثماني في اوربا 1908-1915م
Authors: Abdul Halim Al-Jubouy Emad Hamad Saleh
Published: October 2022

لا توجد بقعة في العالم  حدثت فيها الكثير من الأوهام والاكاذيب كما حدث لشبه جزيرة البلقان، ولاسيما بين الرجال الإنجليز، ولسبب ما أو لآخر ولكثرة القوميات في البلقان المثيرة للاهتمام في بريطانيا وممارسة التأثير على العقل السياسي البريطاني، في حين أن شعب البلقان مر بعدد مختلف من الأدوار قبل ظهوره الى الراي العام البريطاني. وكان ممن تأثر بهذه الاوهام نويل باكستون مؤسس لجنة البلقان.  من خلال تقديم نهج خاص لإصلاح الدولة العثمانية، و موقفه من انقلاب الشبان الاتراك، وحرب البلقان والحرب العالمية الاولى، والموقف المحرج الذي  وضع نفسه به  و تخليه عن الثوابت من اجل المصالح وما تقتضيه السياسة من متغيرات على ارض الواقع.
      يحاول البحث الوقوف على أنشطة باكستون وخلفيته الدينية والشخصية و استنباط افكاره من خلال كتاباته حول الدولة العثمانية وشبه جزيرة البلقان منذ قيام انقلاب الشبان الاتراك على حكم عبد الحميد الثاني حتى عام1915م ، اذ كانت هناك تغيرات في قناعاته نحو المنطقة. فضلاً عن الى محاولة فهم موقف لجنة البلقان ورئيسها نويل باكستون من الوجود العثماني في اوربا وتبنيه قناعات مناهضة لهذا الوجود من خلال العمل على أزاحة العثمانيين من القارة الاوربية، على الرغم من ادعائه الخيرية والعمل الانساني ،ولكن على النمط الاوربي.
حكم امارة بني قرمان ( 634- 677هـ/ 1236- 1278م)
Authors: Ahmed Lama Faik
Published: October 2022

امارة بني قرمان هي احدى الدول الإسلامية التي حكمت الأراضي التركية، حيث ظهرت جنوب اسيا الصغرى وشمال الشام في العصر المملوكي، وقد برز دورهم بعد ضعف سلاطين السلاجقة على المسرح السياسي والعسكري في بلاد الاناضول. بعد سقوط السلطنة السلجوقية تمكن القرمانيون من تأسيس امارة مستقلة واستقروا في العاصمة قونية بعد ان سيطروا عليها عام ( 728هـ/ 1327م).
   لقد أصبح موقع بلاد بني قرمان له أهمية خاصة بعد ان كانوا بين مناطق نفوذ القوى المتنافسة كدولة المماليك في مصر، والمغول في العراق، والدولة العثمانية. ومن جراء ذلك أصبحت محط انظارهم، ودأب بعض امرائهم لمناصرة المغول حينا والمماليك والعثمانيين والسلاجقة حينا آخر .
الحاجات الأكاديمية وعلاقتها بالقيم النفسية لدى طلبة الجامعة
Authors: Rashid Tahrer Nizhan
Published: October 2022

هدف البحث التعرف على مستوى اشباع الحاجات الأكاديمية لدى طلبة الجامعة وعلاقتها بالقيم النفسية لدى طلبة الجامعة وفق متغيرات (الجنس-التخصص) وتكونت عينة البحث من (300) طالب و طالبة منهم (150) طالباً (75) من التخصص العلمي و(75) من التخصص الإنساني و(150) طالبة (75) من التخصص العلمي و(75) من التخصص الإنساني ولهذا الغرض اعدت الباحثة مقياس (الحاجات الأكاديمية) مكون من(28) فقرة مراعية اسس تصميم المقياس العقلية وبعد استخراج الصدق الظاهري والثبات بطريقة اعادة الاختبار بلغ (0,82) والفاكرونباخ (0,86) اما المقياس الثاني (القيم النفسية)مكون من (25)فقرة وبعد استخراج الصدق الظاهري والثبات بلغ بطريقة اعادة الاختبار (0,84)والفاكرونباخ(0,85)وقد طبق المقياسيين على عينة عشوائية من طلبة جامعة تكريت ومن خلال استخدام الوسائل الاحصائية:-
-النسبة المئوية،مربع كاي
   Te-Test- لاختبار التائي لعينة واحدة
 Te-Test- الاختبار التائي لعينتين مستقلتين
  - معامل ارتباط بيرسون
  - الفا كرونباخ
وتوصلت الباحثة إلى عدة نتائج منها:-
-ان طلبة الجامعة لديهم مستوى من الحاجات الأكاديمية
-لاتوجد فروق ذات دلالة احصائية في مستوى اشباع الحاجات الأكاديمية لمتغيري(الجنس-التخصص)
-ان طلبة الجامعة لديهم مستوى من القيم النفسية.
-لاتوجد فروق ذات دلالة احصائية في مستوى اشباع القيم النفسية لمتغيري(الجنس-التخصص).
-وجود علاقة تبادلية بين الحاجات الأكاديمية والقيم النفسية لدى طلبة الجامعة.
Rasgos misóginos en la novela artúrica medieval francesa
Authors:   Universidad Nacional de Educación a Distancia (UNED) (España), Yllera Alicia
Published: October 2022

This paper proposes an analysis of various misogynistic anecdotes that are inserted within the idealized framework of the Arthurian romance, generally considered as an exaltation of courtly love. The study starts with a reflection on this ideal of courtly love and an analysis of some of the misogynistic examples taken from various examples of the Arthurian cycle. It essentially deals with the episodes of the «magic horn» and the «badly cut coat», which appear in independent stories and also in several Arthurian romances.
Themed Section 4: Post-School Education and Training in South Africa
Authors: Dollie Na-iem
Published: October 2022

Introductory and editorial note
A IGREJA EMERGENTE: UM ESTUDO A RESPEITO DO MOVIMENTO
Authors: Cardoso Felipe dos Santos , Lins Junior Daniel da Fonseca
Published: October 2022

Estuda a expressão religiosa pós-moderna intitulada de “movimento da igreja emergente” na tentativa de responder à questão como é possível manter a relevância da igreja, num contexto pós-moderno, sem comprometer a mensagem do evangelho. Inicialmente faz-se uma breve pesquisa sobre a origem e o conceito de “pós-modernismo”, ainda outra sobre a definição, origem e principais características do “movimento da igreja emergente”, e, na sequência, reflete-se sobre as implicações decorrentes das compreensões emergentes. Este trabalho se desenvolve a partir de pesquisa qualitativa realizada através da utilização de materiais bibliográficos. A argumentação apresentada no texto considera a importância de se conhecer o movimento e conclui que dele decorrem riscos que devem ser evitados e contribuições com as quais a igreja cristã pode se beneficiar.
К вопросу о хирургическом лечении больших макулярных разрывов (клинический пример)
Authors:   Ufa Eye Research Institute, Ufa, Russian Federation, Orenburkina O.I. , Zinnatullin A.A. ,   Ufa Eye Research Institute, Ufa, Russian Federation, Yarmukhametova A.L. ,   Ufa Eye Research Institute, Ufa, Russian Federation, Babushkin A.E. ,   Ufa Eye Research Institute, Ufa, Russian Federation, Kalanov M.R. ,   Ufa Eye Research Institute, Ufa, Russian Federation
Published: October 2022

Macular hole (MH) is a layered through defect in the central part of the retina from the inner boundary membrane (IBM) to the outer layer of photoreceptors, leading to a decrease in vision, and in some cases to disability (related to vision). Surgical treatment of MH is one of the most actively developing areas in modern ophthalmology. The article considers a clinical case of the proposed method of macular hole treatment in complicated cataract (RF patent No. 2731794 dated 08.09.2020). It is shown that in order to increase the anatomical and functional efficiency in the presence of large macular holes, it is recommended to use the developed method of surgery using an autocapsule of the lens taken during cataract phacoemulsification. It allows you to restore the structure of the outer retinal layers and achieve high functional results. Keywords: macular hole, lens capsule, capsulorexis, phacoemulsification, cataract.
Complicated subcapsular cataract in patients with phakic posterior chamber intraocular lenses as a complication in the late postoperative period
Authors:   Ltd ", Peregudov D.V. ,   3Z",   , Branch in Moscow, Kuznetsova O.Y. ,   Ltd "3Z", Branch in Moscow, Perevozchikov P.A. ,   Ltd "3Z", Branch in Moscow
Published: October 2022

According to the World Health Organization, around 2.2 billion people worldwide suffer from near or far vision impairment. However, there is a large cohort of patients with absolute contraindications for refractive surgery, and for these patients, phakic intraocular lens (PIOL) implantation is the best option. One of the complications after PIOL implantation, which both surgeons and patients fear, is the сomplicated subcapsular cataract development. The article presents a clinical case of a patient with two posterior chamber phakic IOLs, who underwent re-implantation of the PIOL in one eye, and phacoemulsification of cataract, which developed as a complication of the PIOL, in the other. Keywords: phakic intraocular lens, complicated subcapsular cataract, extended focus intraocular lens
Efficacy safety analysis of the new aspheric hydrophobic acrylic monofocal iol implantation at short-term follow-up
Authors:   «Eximer» eye center, Moscow, Russia, Pershin K.B. ,   Ophthalmology faculty, Academy of postgraduate education of The Federal Medical-Biological Agency, Moscow, Russia, Pashinova N.F. ,   «Eximer» eye center, Moscow, Russia,   Ophthalmology faculty, Academy of postgraduate education of The Federal Medical-Biological Agency, Moscow, Russia, Tsygankov А.I. ,   «Eximer» eye center, Moscow, Russia, Korneeva E.A. ,   «Eximer» eye center, Moscow, Russia
Published: October 2022

Perpose. To evaluate the results of implantation of a new hydrophobic acrylic monofocal IOL in an automated preloaded delivery system in the short-term follow-up period. Material and methods. The prospective study included 89 patients (114 eyes) after bilateral or monolateral Clareon IOL implantation with a mean follow-up of 2.1 ± 0.4 (1–4) months. The age range was 53 to 87 (71.1 ± 5.2) years. A corneal incision of 1.8 mm was used in all cases. For implantation using the AutonoMe® system, the incision was enlarged by 0.2 mm for implantation IOL 26 D and higher. IOL optical power was calculated using the SRK/T formula; retrospective analysis was performed using the Hoffer Q, Haigis, Holladay II, Olsen, Barrett Universal II, and Kane formulas. Results. In all studied periods (1 day, 1 week and 1 month) there was statistically significant (p < 0.05) increase both of NCDVA (from 0.13 ± 0.02 in the preoperative period to 0.81 ± 0.07 in 1 month after surgical intervention), and BCDVA (from 0.32 ± 0.15 before surgery to 0.94 ± 0.11 after surgery). When assessing the percentage of eyes with an BCDVA of 0.9 or higher, a statistically significant (p < 0.05) difference was shown in all studied periods. The lowest MAE was shown for the Barrett Universal II (0.292), SRK/T (0.312) Kane (0.301), and Olsen (0.325) formulas. For the Hoffer Q and Holladay 2 formulas, MAE values were significantly higher (p < 0.05). The highest frequency of achieving the target refraction of ±0.25 D was shown for the Barrett Universal II and Kane formulas (68 and 69 %, respectively), and the lowest for the Hoffer Q and Holladay 2 formulas (28 and 35 %, respectively). The primary endpoint of the study (BCDVA =1.0) was achieved in 95.6 % (n = 109), with a deviation in BCVA of ±0.1 noted in 4 eyes (3.5 %). No glistening was detected in the follow-up period up to 4 months. Conclusion. The paper presents an analysis of the first experience with the implantation of new Clareon monofocal IOLs in Russian Federation. The results of implantation of a new hydrophobic acrylic monofocal IOL in an automated preloaded delivery system showed a good clinical and functional effect, a high frequency of achieving the target result and the absence of significant side effects. The Kane, Barrett Universal II, and SRK/T formulas, using the Verion diagnostic navigation system, are recommended for calculating the optical power of the new IOL. Keywords: cataract; monofocal IOL; Clareon; glistening.
Calculation of intraocular lens optical power with enhanced depth of focus
Authors:   ", Pershin K.B. ,   Excimer",   Eye Centre, Moscow, Russian Federation,   Ophthalmology faculty, Academy of postgraduate education of The Federal Medical-Biological Agency, Moscow, Russian Federation, Pashinova N.F. ,   "Excimer" Eye Centre, Moscow, Russian Federation,   Ophthalmology faculty, Academy of postgraduate education of The Federal Medical-Biological Agency, Moscow, Russian Federation, Tsygankov A.Y. ,   "Excimer" Eye Centre, Moscow, Russian Federation, Antonov E.A. ,   "Excimer" Eye Centre, Moscow, Russian Federation
Published: October 2022

Perpose. Retrospective analysis of the accuracy of 7 formulas for optical power calculation of a new extended depth of focus intraocular lens. Methods. The retrospective study included 34 patients (62 eyes) with implantation of a new EDOF Tecnis Symfony IOL ZXR00. The mean age of the patients was 61.9 ± 9.4 (39–87) years. IOL optical power range was +5.0 to +30.0 D, target refraction was –0.25 to 0.25 D. The average follow-up period for the patients was 12.3 ± 1.8 months. The SRK/T, Barrett Universal II, Haigis, Hoffer Q, Holladay 2, Olsen, and Kane formulas were retrospectively analyzed for effectiveness using appropriate constants. Each formula was optimized for the study group of patients to achieve an average refractive error as close to zero as possible. For each formula, the mean error (ME), mean absolute error (MAE), standard deviation (SD), median absolute error (MedAE), maximum absolute error (MaxAE), and percentage of eyes within the error range of 0.25, 0.5, 1.0, and 2.0 D were calculated. Results. The optimized constants were LF = 2.21, a0 = 1.43, a1 = 0.39, a2 = 0.12, personalized ACD = 5.68, ACD (Hoffer Q/Holladay 2) = 5.68/5.66, A-constant (SRK/T/Kane) = 119.5/119.4. For the SRK/T, Barrett Universal II, Kane and Haigis formulas the lowest MAE is shown. Application of the Hoffer Q and Holladay 2 formulas are associated with the highest MAE. The Barrett Universal II, SRK/T, Kane, and Haigis formulas were characterized by the highest percentage of reaching refraction of ±0.25 D (64, 62, 59, and 53 %, respectively). For all of the formulas examined, the frequency of reaching refraction of ±1.00 D was greater than 90 % and within ±2.00 D greater than 97 %. Conclusion. This study was the first to retrospectively compare seven formulas for calculating the optical power of a new intraocular lens with an enhanced depth of focus. The SRK/T, Barrett Universal II, Haigis, and Kane formulas are recommended for calculating the optical power of the indicated IOL in clinical practice. Keywords: cataract, phacoemulsification, EDOF, Symfony, IOL optical power calculation, constant optimization.
Implantation and calculation features of a new extended depth of focus IOL vivity DFT015
Authors:   St. Petersburg branch of ISTC ", Shukhaev S.V. ,   Eye Microsurgery",   them acad. S.N. Fedorov, Russia, Mordovtseva E.A. ,   St. Petersburg branch of ISTC "Eye Microsurgery" them acad. S.N. Fedorov, Russia, Boiko E.V. ,   St. Petersburg branch of ISTC "Eye Microsurgery" them acad. S.N. Fedorov, Russia,   North-Western State Medical University n.a. I.I. Mechnikov, Saint-Petersburg, Russia,   S.M. Kirov Military Academy, Saint-Petersburg, Russia, Nemsitsveridze M.N. ,   St. Petersburg branch of ISTC "Eye Microsurgery" them acad. S.N. Fedorov, Russia, Khizhnyak I.V. ,   St. Petersburg branch of ISTC "Eye Microsurgery" them acad. S.N. Fedorov, Russia, Chizh L.V. ,   St. Petersburg branch of ISTC "Eye Microsurgery" them acad. S.N. Fedorov, Russia
Published: October 2022

Purpose. To evaluate the results of implantation of the Vivity IOL in patients with cataract and refractive lensectomy. Material and methods. The study included 25 patients (42 eyes) who underwent phacoemulsification or refractive lens exchange with Vivity IOL implantation. The mean age of the patients was 56.4 ± 11.75 years. The results were evaluated 1 month after the surgery. Postoperative visual acuity was measured monocularly at a distance and at an intermediate. The IOL was calculated using three formulas: Kane, Hill-RBF, EVO. The mean absolute (MAE) and median (MedAE) calculation errors were calculated. Results. One month after the surgery patients with lens exchange and cataracts distance and intermediate visual acuity was 0.88 ± 0.17 and 0.76 ± 0.12, 0.91 ± 0.23 and 0.81 ± 0.11 respectively. The mean absolute error according to the formulas ranged from 0.31 to 0.33 D. Pairwise comparison of the calculation accuracy revealed no significant differences (p > 0.05). Conclusion. The new non-diffractive EDOF IOL Vivity DFT015 demonstrated high visual functions at long and medium distances, as well as high calculation accuracy using three modern calculators. Keywords: phacoemulsification, IOL with extended depth of focus, cataract.
Ultrastructural changes in corneal collagen of research animals after uv corneal cross-linking
Authors:   Ufa Eye Research Institute, Ufa, Bikbov M.M. , Khalimov A.R. ,   Ufa Eye Research Institute, Ufa, Shevchuk N.E. ,   Ufa Eye Research Institute, Ufa, Surkova V.K. ,   Ufa Eye Research Institute, Ufa, Usubov E.L. ,   Ufa Eye Research Institute, Ufa, Kazakbayeva G.M. ,   Ufa Eye Research Institute, Ufa
Published: October 2022

Purpose. Electron microscopy analysis of collagen fibrils in the corneal stroma of rats after UV cross-linking. Material and methods. Experiments were carried out on rats in 2 groups: 1st – control (intact), 2nd – experiment (UV corneal cross-linking with riboflavin). The observation period is 3, 90 days. The UV irradiation power of the cornea is 3 mW / cm², the duration is 10 minutes. For electron microscopic examination, corneal pieces were fixed in a solution of 2 % glutaraldehyde. Dehydration and pouring were carried out according to the generally accepted method. Ultrathin sections were obtained using the ultramicrotome "Leica EM UC7" (Leica Microsystems) and viewed in the electron microscope JEM-1011 (Jeol). To determine the density of fibrillar packing of corneal collagen fibers, microphotographs were analyzed at magnification ×15,000. The number of collagen fibrils on an area of 250,000 nm² was calculated. The same microphotographs were used to measure the diameter of collagen fibrils. All numerical data were processed by the method of variational statistics. Histograms of the normal diameter distribution of collagen fibrils were analyzed. Results. The ultrastructure of corneal collagen on the 3rd day after UV corneal crosslinking was characterized by an increase in the interfibrillary space. This indicator was partially restored to its original values on the 90th day. At the same time, the fibrils retained the correct shape and sequence. The results of the analysis of the normal distribution of the diameter of collagen fibrils indicated an increase of an average of 10 %. Conclusion. An increase in the interfibrillary space after UV corneal crosslinking is probably associated with the development of postoperative stroma edema, which can be observed up to several months at the ultrastructural level. The revealed increase in the diameter of collagen fibrils is one of the factors increasing the strength and mechanical properties of the cornea. Keywords: UV cross-linking of rat cornea, electron microscopy, diameter of collagen fibrils, interfibrillary space.
Finding the most optimal method for preoperative assessment of the risk of developing dry eye syndrome by comparing the effectiveness of corneotopography and norn's test before photorefractive surgery in patients with myopia
Authors:   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation, Kolenko O.V. ,   Postgraduate Institute for Public Health Workers, Khabarovsk, Russian Federation, Kutuzova Y.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation, Dutchin I.V. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation, Sorokin E.L. ,   The S. Fyodorov Eye Microsurgery Federal State Institution, the Khabarovsk Branch, Khabarovsk, Russian Federation,   Far-Eastern State Medical University, Khabarovsk, Russian Federation
Published: October 2022

Purpose. To conduct a comparative analysis of the effectiveness of assessing the stability of the tear film using corneotopography and the classic Norn test in patients with myopia and myopic astigmatism before keratorefractive surgery. Material and methods. The study included 26 patients planned for keratorefractive surgery for myopia and myopic astigmatism, aged 18 to 47 years. 7 people there was a mild degree of myopia, in 14 people – medium degree, in 5 people – high degree. The average degree of corneal astigmatism was 2.25 diopters. The stability of the pre-corneal tear film was assessed using computed keratotopography and Norn's test – the tear film rupture time (TFRT) was determined. A standard questionnaire was also used to assess the severity of symptoms of dry eye syndrome. A comparison was made of the indicators of the stability of the tear film obtained by the methods of corneotopography and the Norn's test, with their subsequent comparison with the data of the questionnaire. Results. In 17 patients (65.4 %), the TFRT index corresponded to the age norm. In the remaining 9 people (34.6 %), indicators of stability of the tear film were reduced both by corneotopography (12 ± 4 sec) and by Norn's test (13.5 ± 4.5 sec), and there were also subjective signs of dry eye syndrome according to data questionnaire. The data turned out to be comparable. Conclusions. 1. Among the total population of patients, 34.6 % were persons with impaired tear film stability and subjective manifestations of dry eye syndrome. 2. Assessment of the stability of the tear film, determined using the method of corneal topography, showed a high degree of comparability with the results of Norn's test. A significant advantage of the keratotopography method is its non-invasiveness. 3. It is necessary to pay attention to the condition of the ocular surface and identify risk groups to avoid chronicity or aggravation of existing disorders. Keywords: dry eye syndrome, tear film, keratotopography, Norn's test.
Evaluation of the femtolasic refractive effect in the correction of hypermetropia in patients with initially high uncorrected visual acuity
Authors:   Irkutsk Branch of S.N. Fyodorov Eye Microsurgery Federal State Institution, Ministry of health of the Russian Federation, Frolova T.N. , Iureva T.N. ,   Irkutsk Branch of S.N. Fyodorov Eye Microsurgery Federal State Institution, Ministry of health of the Russian Federation,   Irkutsk State Medical Academy of Postgraduate Education – Branch Campus of the Russian Medical Academy of Continuing Professional Education, Irkutsk, Russian Federation,   Irkutsk State Medical University, Irkutsk, Russian Federation, Pisarevskaya O.V. ,   Irkutsk Branch of S.N. Fyodorov Eye Microsurgery Federal State Institution, Ministry of health of the Russian Federation, Khlebnikova L.S. ,   Irkutsk Branch of S.N. Fyodorov Eye Microsurgery Federal State Institution, Ministry of health of the Russian Federation, Korolenko A.V. ,   Irkutsk Branch of S.N. Fyodorov Eye Microsurgery Federal State Institution, Ministry of health of the Russian Federation
Published: October 2022

Hypermetropic refraction is not always accompanied by a decrease in uncorrected visual acuity (UCVA) and can be 0.9–1.0. This explains that, despite asthenopic complaints and the difficulty of working near, quite often such patients do not use optical correction. At the same time, patients with high and moderate hypermetropia, having uncorrected visual acuity exceeding 0.8, are usually denied refractive interventions, recommending the use of optical correction. The purpose was to evaluate the results of the refractive effect of hypermetropia correction by Femtolasic in patients with initially high uncorrected visual acuity. On the first day after surgery, all patients experienced an increase in visual acuity near 1–2 lines, at the same time, in 70 % of cases, there was a decrease in UCVA in the distance from 0.5 to 1 line, the total number of aberrations decreased by 4 times. A month after treatment, UCVA in the distance in all patients was maximal and was in the range of 0.9–1.1, UCVA in the vicinity varied from 0.9 to 1.0, the total number of eye aberrations averaged 1.13 ± 0.18, which was almost 3 times lower than preoperative values. All patients were satisfied with the quality of vision near and at an average distance, and noted an increase in visual acuity in the distance and the ability to work comfortably with a computer for a long time. The improvement of the quality of vision and accommodation adaptation in the early stages after surgery indicate the expediency of the treatment in patients with grade 2 and 3 hypermetropia with initially high rates of UCVA. Keywords: hypermetropia, high uncorrected visual acuity, Femtolasic laser correction.
Clinical cases of intraoperative and postoperative opacification of intraocular lenses
Authors:   Kirov state ophthalmology hospital, Kudyavtseva Y.V. ,   FSBEI HE Kirov SMU MOH Russia, Gavrilova I.A. ,   Kirov state ophthalmology hospital,   FSBEI HE Kirov SMU MOH Russia, Demakova L.V. ,   Kirov state ophthalmology hospital,   FSBEI HE Kirov SMU MOH Russia, Ermolova A.A. ,   Kirov state ophthalmology hospital, Plotnikova Y.A. ,   Kirov state ophthalmology hospital,   FSBEI HE Kirov SMU MOH Russia
Published: October 2022

In recent years, reports of opacities of intraocular lenses during or at various times after cataract surgery have been increasingly appearing. The aim of the work was to study clinical cases of intraoperative and postoperative transient opacities of intraocular lenses. There were 5 cases of acute intraoperative turbidity of IOLs from hydrophilic acrylic (I-flex, Germany) and 23 cases of turbidity of IOLs from hydrophobic acrylic (Citrin, NanOptika LLC) in the postoperative period (group 2). Cases of opacities of intraocular lenses have shown that the most justified is a wait-and-see tactic, since in the future IOLs from hydrophilic acrylic spontaneously restored transparency, and the effect of glistening hydrophobic IOLs did not affect the quality of vision of patients. Keywords: turbidity of intraocular lens, hydrophilic acrylic, hydrophobic acrylic.
Endoscopic cyclophotocoagulation in combined surgery of cataract and glaucoma
Authors:   S.M. Kirov Military Medical Academy Federal State Budgetary Educational Institution of Higher Education ", Kulikov A.N. ,   Military Medical Academy named after A.I. S.M. Kirov",   , St. Petersburg, Skvortsov V.Y. ,   S.M. Kirov Military Medical Academy Federal State Budgetary Educational Institution of Higher Education "Military Medical Academy named after A.I. S.M. Kirov", St. Petersburg, Tulin D.V. ,   S.M. Kirov Military Medical Academy Federal State Budgetary Educational Institution of Higher Education "Military Medical Academy named after A.I. S.M. Kirov", St. Petersburg
Published: October 2022

Combined surgical treatment in patients with refractory glaucoma and cataract allows achieving stable compensation of intraocular pressure and having a significant improvement in visual functions. Purpose. To study of some aspects of efficacy and safety of combined endoscopic cyclophotocoagulation (ECP) with cataract phacoemulsification. Methods. 78 patients with uncompensated open-angle glaucoma at various stages. They were treated with ECP and cataract extraction. Among them were 40 (51.28 %) men and 38 (48.72 %) women. The follow-up period is from 6 to 48 months. The mean age of the patients was 73.46 years. Results. At the end of the follow-up period, there was a significant decrease in the mean IOP to 18.2 ± 1.5 mmHg, in comparison with the initial level of 24.1 ± 3.2 mmHg (p < 0.0001). At the same time, full success was achieved in 46.6 % (34 eyes). Partial success (reduction of IOP to 21 mmHg and below) was achieved in 51.3 % (40 eyes). The number of topical glaucoma drugs used also significantly decreased from 2.5 ± 1.0 to 1.9 ± 1.0 (p = 0.001). Moderately pronounced postoperative iridocyclitis found in 25.64 % of cases. Conclusion. ECP can be considered as a more significant component of the MIGS conception. Keywords: glaucoma, transscleral laser cyclodestruction, endoscopic cyclophotocoagulation, microinvasive glaucoma surgery.
LIST OF SENSORY LOSSES CAUSED BY COVID-19 IN QUALITY OF LIFE
Authors: DE MEDEİROS Camille , SANCHEZ Andrea , FORLANDİ Fabiana De Souza , ANTONİO-VİEGAS Mayara Caroline Ribeiro , MORENO Munik De Oliveira , FACİN Victoria
Published: October 2022

Introduction: The World Health Organization declared, in January 2020, an outbreak of COVID-19 caused by SARS-CoV-2. Among the most common symptoms of COVID-19 are fever, cough, tiredness, ageusia and anosmia, with breathing difficulties being considered the serious effects. Several studies have shown that patients recovered from COVID-19 may continue to present sensory losses as well as other changes related to the central nervous system, constituting the post-covid syndrome. Objective: To analyze and evaluate in the literature the prevalence and impact of sensory dysfunctions caused by COVID-19 on the population's quality of life. Method: This is an integrative literature review, carried out in November 2021, in the SciELO, LILACS and PubMed databases, selecting articles published in Portuguese, in the years 2020 to 2021. The descriptors were: Ageusia, Anosmia , COVID-19, Quality of Life and Population, identifying similarities between studies that answered the guiding question: “What are the impacts of sensory losses caused by COVID-19 on quality of life?”. Results: Eighteen scientific articles that met the inclusion criteria were found and evaluated. According to the research carried out, it can be seen that cognitive and sensory changes have become much more common after COVID-19, mainly due to the loss of neurons caused by the disease. Conclusions: It is concluded that sensory losses related to SARS-CoV-2 infection have a significant biopsychosocial impact, with repercussions at a personal, social and even professional level. it is noted that these events can lead to changes in health-related quality of life, and it is extremely important to analyze the consequences of these losses.