bluuebunny/crossref_metadata_2025 huggingface dataset:
Learning Design Subjects Of Criticism In Class IX Online and Offline MTsN 1 Sintang
Authors: Yuyu Wahyudin  , Sukino  , Erwin Mahrus
Published: August 2023

The purpose of this study was to determine the suitability of the RPP for Akidah Akhlak class IX teachers with the principles of developing online and offline learning during the Covid 19 Pandemic based on KMA No 183 and KMA N0 184 of 2019 which were issued by the Minister of Religion of the Republic of Indonesia. In this study, the researcher attempted to interview a teacher of Akidah Akhlak at MTsN 1 Sintang whose name was Mrs. Suchudianti, S.Pd.I. She compiled a Learning Implementation Plan with the theme of Online and Offline Learning Tools for Akidah Akhlak Class IX for the 2021/2022 Academic Year.This type of research is field research, while the method used in this study is descriptive qualitative, namely the research produces descriptive data in the form of the suitability of the teacher's lesson plan with the principles of development based on KMA No. 183 and KMA No. 184 of 2019. The data and data sources in this study are in the form of 3 RPP Akidah Akhlak teachers from three (3) different Madrasas, namely 1) MIN 1, 2) MTsN 1 Sintang, and 3) MAN 1 Sintang. Data collection techniques in this study used techniques (1) document collection (2) interviews (3) observation. The results showed that the suitability of the teacher's lesson plan with the principles of elaborating the idea of KMA No. 183 and the syllabus was not appropriate because there were many factors that influenced it because the KMA included online student learning tools, namely using tools through the Whattsapp group, Goegle Meet, and E. Learning. Because during the Covid 19 pandemic all learning was carried out online, forcing all educational components to adapt to this very difficult situation. Parents are required to prepare tools for online learning, namely handponds so that children can learn remotely.
Developing Critical And Creative Thinking-Based Islamic Religious Education Learning Designs Using Discovery Learning Strategies Through Saintificate Approaches
Authors: Zumzianah  , Wahab
Published: August 2023

This research aims to describe and analyze the development of Islamic Religious Education learning design based on critical and creative thinking with a scientific approach to discovery learning strategies. This research method uses qualitative research with descriptive research types. The primary data sources in the study were Islamic Religious Education teachers, students, and school principals. Secondary data sources are in the form of books, research journals, and documentation. Data collection techniques using observation, interviews, and documentation. Data analysis techniques use data reduction, analysis, interpretation, and triangulation. The results of this study state that the learning process of jurisprudence still uses a lot of methods that are less interesting because it is too monotonous to only use one method, namely the lecture method, without being balanced with other methods, so the learning atmosphere is less attractive, looks pretty dull, without the support of exciting media and facilities. as did MTsN teachers, and State MA teachers.
Relevance Of The Bidāyat Al-Tauhīd Book Works Of Sheeykh Muhammad Basiuni Imran In Islamic Religious Education Curriculum In Schools
Authors: Masruji  , Erwin Mahrus
Published: August 2023

This study aims to examine the relevance of Muhammad Basiuni Imran's work, namely a book entitled the full Bidāyat al-Tauhīd fī 'Ilmi al-Tauhīd with the Islamic Religious Education (PAI) curriculum in schools. The research method used is literature study, which is an analysis of the contents of this book of monotheism and the PAI curriculum in schools. The results of the study show that this book has great relevance to the PAI curriculum in schools. Muhammad Basiuni Imran's work has a significant contribution to the Islamic Religious Education curriculum at all levels of education. This data can become information for the development of teaching materials and learning methods that are more effective and efficient. This work can be a useful reference for policy makers and educators in developing a more comprehensive Islamic education curriculum.
Teacher Efforts and The Characteristics Of Islamic Religious Education Teacher In Improving Students' Reading Ability
Authors: Rani Darmasari  , Wahab
Published: August 2023

The background of this research is the teacher's efforts related to how a teacher is able to understand and determine the boundaries that must be carried out by a teacher in organizing material, interacting, and carrying out learning processes for students of SDN 09 Nanga Sayan. This is good, marked by enthusiastic participation direct learning, asking questions and answering teacher questions, and paying attention to the teacher during learning. This is what makes researchers interested in conducting more in-depth research. This research is focused on (1) How are the Efforts of Islamic Religious Education Teachers and Characteristics in Students of SDN 09 Nanga Sayan for the 2022/2023 Academic Year? (2) How is the Ability to Read the Qur'an in Students of SDN 09 Nanga Sayan for the 2022/2023 Academic Year? (3) What are the Efforts of Islamic Religious Education and Character Education Teachers in Improving the Ability to Read the Qur'an in Students of SDN 09 Nanga Sayan for the 2022/2023 Academic Year?This research is a type of descriptive research with a qualitative approach. Data collection procedures carried out are using observation techniques, interviews, and documentation. Researcher interviews were conducted with ethics subject teachers.Based on the results of the study, it can be concluded as follows: (1) The efforts of Islamic Religious Education and Characteristics Teachers to instill a sense of enthusiasm and also provide motivation in various ways, moreover teaching children who are just learning to read the Qur'an is something that is certain. not easy. (2) Students' Ability to Read the Qur'an in SDN 09 Nanga Sayan found that there are some children who can read the Qur'an and some who cannot read the Qur'an. (3) Efforts of Islamic Religious Education and Moral Education Teachers in Improving Al-Qur'an Reading Ability at SDN 09 Nanga Sayan by repeating hijaiyah letters such as the letter ba, what it looks like in front, what it looks like in the middle and what it looks like at the end
Penyuluhan tentang KB di Kecamatan Parigi Kabupaten Pangandaran
Authors: Nurohmah Irma , Sa’adah Ratna , Apit Apit , Melati Elita Putri
Published: August 2023

Program Keluarga Berencana Nasional merupakan salah satu program sosial dasar yang sangat penting bagi kemajuan suatu bangsa. Program Keluarga Berencana adalah program nasional yang bertujuan meningkatkan derajat kesehatan, kesejahteraan ibu, anak dan keluarga, serta bangsa dan negara. Menurut WHO, Keluarga Berencana adalah tindakan yang membantu individu atau pasangan suami istri untuk menghindari kelahiran yang tidak diinginkan, mendapatkan kelahiran yang memang diinginkan, mengatur interval kehamilan, mengontrol waktu saat kelahiran dalam hubungan dengan umur suami istri dan menentukan jumlah anak dalam keluarga. Tujuan kegiatan penyuluhan ini yaitu untuk memberikan edukasi dan pemahaman mengenai pentingnya mengikuti program KB. Metode yang dilakukan pada saat kegiatan penyuluhan yaitu dalam bentuk ceramah yang kemudian terdapat sesi tanya jawab dan diskusi setelah pemaparan materi oleh narasumber. Hasil kegiatan yang dihadiri oleh 13 orang ini semuanya mengikuti program KB karena peserta merupakan lini lapangan/pos dari tiap-tiap desa yang kemudian akan disampaikan kembali kepada masyarakat atau pasangan usia subur di desa masing-masing.
Pola Interaksi Guru dan Murid dalam Proses Pembelajaran di MAS Al-Furqon Cimerak
Authors: Hakim Maulana Adam
Published: August 2023

Di dalam penelitian ini akan membahas bagaimana pola interaksi guru dengan murid dalam proses pembelajaran. Penelitian ini dilaksanakan di MAS Al-Furqon Cimerak, Metode dalam penelitian ini menggunakan metode penelitian kualitatif. Teknik pengemupulan data dalam penelitian ini menggunakan teknik secara tringulasi yaitu Observasi, wawancara dan dokumentasi. Penelitian ini bertujuan untuk mengetahui pola interaksi guru dengan murid dalam proses pembelajaran. Hasil dari penelitian ini menunujakan bahwa pola interaksi yang sering dilakukan di MAS Al-Furqon Cimerak yaitu pola interaksi satu arah dengan mengunakan metode ceramah, Komunikasi dua arah sering dilakukan dengan melakukan tanya jawab sepertihalnya kuis, Dan komunikasi tiga arah dilakukan dengan pemberian materi kepada para peserta didik untuk didiskusikan oleh setiap kelompoknya masing-masing dan dipersentasikan Kembali. Pola interaksi yang dilakuan di MAS Al-Furqon Cimerak bertujuan untuk menyiptakan kelas yang bernilai edukatif.
Kepribadian dan Parenting Anak Usia Dini
Authors: Sutansyah Lexy , Rahma Alfi Maulia , Yunita Rika
Published: August 2023

Individu pada masa anak usia dini memiliki kehadiran yang unik dan istimewa. Mengalami proses pertumbuhan dan perkembangan yang pesat dan kepemilikan dunia sangat penting untuk kehidupan selanjutnya. Anak selalu memiliki karakteristik yang jauh dari orang dewasa. Antusias dan aktif, selalu ingin tahu tentang apa yang dilihat dan dinamis. Jangan pernah berhenti belajar, karena suara pengetahuan baru harus selalu didengar. Penelitian ini mengunakan metode kualitatif untuk mengeksplorasi dan memahami makna yang diperoleh sejumlah individu atau sekelompok orang dianggap berasal dari masalah sosial atau kemanusiaan. Pengembangan karakter kepribadian penting sekali dilakukan ketika anak dalam masa-masa usia dini. Freud, namun Erik Erikson tidak sependapat dengan Freud yang mengatakan bahwa reaksi masa dewasa adalah hasil dari pengalaman-pengalaman masa kanak-kanak, khususnya di usia 5 sampai 6 tahun awal. Menurut Erikson, lingkungan di mana anak hidup sangat penting untuk memberikan pertumbuhan, penyesuaian, sumber kesadaran diri dan identitas Pengembangan karakter kepribadian penting sekali dilakukan ketika anak dalam masa-masa usia dini. Vigotsky memandang bahwa sistem sosial sangat penting dalam perkembangan kognitif anak. Pengembangan karakter dalam diri anak diarahkan pada nilai, sikap, dan perilaku yang memancarkan akhlak mulia atau budi pekerti luhur.
Akademik Becerilerin İzlenmesi ve Değerlendirilmesi (ABİDE) Matematik Akademik Başarılarını Açıklayan Öğrenci Özelliklerinin İncelenmesi
Authors: Gür Recep , Yıldırım Ahmet
Published: August 2023

Akademik Becerilerin İzlenmesi ve Değerlendirilmesi’ne (ABİDE) ilişkin yayımlanan raporlarda genelde tekil olarak öğrenci başarısını etkileyen değişkenler ele alınmaktadır. Bu araştırmada, ABİDE 2016 uygulamasında öğrencilerin matematik başarılarını etkileyen öğrenci özellikleri birlikte ele alınıp incelenmiştir. Bu bağlamda, sekizinci sınıf öğrencilerinin matematik alanında sahip oldukları bilgileri, gündelik yaşama ne kadar uygulayabildikleri çok yönlü incelendiğinden ve öğrencilerin akademik başarılarını açıklayan faktörler belirlendiğinden, öğrencilerin ilgili alanlardaki performanslarını artıracak öğretim programlarının oluşturulması ve öğrenme-öğretme ortamlarının düzenlenmesi açısından ilgili kurumlara, araştırmacılara ve politikacılara katkıda bulunması beklenmektedir. Korelasyonel araştırma modelindeki bu araştırmada, sekizinci sınıf öğrencilerinin ABİDE 2016 matematik alt testi akademik başarılarını açıklayan öğrenci özelliklerinin neler olduğunun belirlenmesi amaçlanmıştır. Sekizinci sınıf öğrenci özellikleri incelendiğinde, en yüksekten en düşüğe doğru sırasıyla “eğitimlerindeki hedefleri”, “kardeş sayısı”, “evdeki dergi, gazete ve ders kitapları dışında kitap sayısı”, “sosyoekonomik düzey”, “devamsızlık sıklığı” ve “matematik öz-yeterliği”, öğrencilerin ABİDE matematik akademik başarı puanlarını açıklamıştır. Öğrencilerin sosyoekonomik düzeyi yükseldikçe, evdeki dergi, gazete ve ders kitapları dışında kitap sayısı ve matematik öz-yeterlik puanları arttıkça matematik akademik başarı ortalama puanları artmakta iken öğrencilerin genellikle kardeş sayısı ve devamsızlık sıklığı arttıkça matematik akademik başarı puanlarının azaldığı sonucuna ulaşılmıştır.
Burnout, COVID-19, social support and food insecurity in health workers
Authors: Colichi Rosana Maria Barreto , Bernardo Larissa Cassiano , Baptista Simone Cristina Paixão Dias , Fonseca Alan Francisco , Weber Silke Anna Theresa , Lima Silvana Andrea Molina
Published: August 2023

Objective: To evaluate the prevalence of risk for Burnout Syndrome among health professionals in areas of care for patients with COVID-19, as well as to verify possible associations of the syndrome with the perceived social support and food insecurity of these workers.

Methods: Analytical cross-sectional study, with workers from intensive care units (ICU) and wards caring for patients with COVID-19, in a university hospital. Data collection was carried out from September to October 2021, using the instruments: Maslach Burnout Inventory (MBI-HSS), Multidimensional Perceived Social Support Scale and Food Insecurity Experience Scale (FIES). Statistical analysis used Poisson regression models and multiple Poisson regression, considering statistically significant differences and associations if p<0.05.

Results: A total of 75 workers from three wards (48%) and from one ICU (52%) participated in the survey, and the professionals are mostly female (89.3%), trained as health care technicians (66.7%). Regarding the risk of Burnout Syndrome, 26.7% of the workers had scores for at least one dimension of the scale, mainly referring to high emotional exhaustion (20%). There was a positive association between the risk of developing Burnout Syndrome and food insecurity (PR = 1.11; 95%CI = (1.04; 1.18); p = 0.002). The number of children was significantly negatively associated with the incidence of Burnout Syndrome (PR = 0.90; 95%CI = (0.83; 0.97); p = 0.008).

Conclusion: Positive associations were observed with a higher risk of BS in professionals with food insecurity and also that the number of children acts as a protective factor against the risk of Burnout Syndrome, which may be directly related to perceived social support.
Burnout, COVID-19, social support and food insecurity in health workers
Authors: Colichi Rosana Maria Barreto , Bernardo Larissa Cassiano , Baptista Simone Cristina Paixão Dias , Fonseca Alan Francisco , Weber Silke Anna Theresa , Lima Silvana Andrea Molina
Published: August 2023

Abstract

Objective

To evaluate the prevalence of risk for Burnout Syndrome among health professionals in areas of care for patients with COVID-19, as well as to verify possible associations of the syndrome with the perceived social support and food insecurity of these workers.

Methods: Analytical cross-sectional study, with workers from intensive care units (ICU) and wards caring for patients with COVID-19, in a university hospital. Data collection was carried out from September to October 2021, using the instruments: Maslach Burnout Inventory (MBI-HSS), Multidimensional Perceived Social Support Scale and Food Insecurity Experience Scale (FIES). Statistical analysis used Poisson regression models and multiple Poisson regression, considering statistically significant differences and associations if p<0.05.

Results: A total of 75 workers from three wards (48%) and from one ICU (52%) participated in the survey, and the professionals are mostly female (89.3%), trained as health care technicians (66.7%). Regarding the risk of Burnout Syndrome, 26.7% of the workers had scores for at least one dimension of the scale, mainly referring to high emotional exhaustion (20%). There was a positive association between the risk of developing Burnout Syndrome and food insecurity (PR = 1.11; 95%CI = (1.04; 1.18); p = 0.002). The number of children was significantly negatively associated with the incidence of Burnout Syndrome (PR = 0.90; 95%CI = (0.83; 0.97); p = 0.008).

Conclusion: Positive associations were observed with a higher risk of BS in professionals with food insecurity and also that the number of children acts as a protective factor against the risk of Burnout Syndrome, which may be directly related to perceived social support.
ICNP® terminology subset for people with chronic kidney disease under conservative treatment
Authors: Menezes Harlon França de , Camacho Alessandra Conceição Leite Funchal , Sant’Anna Rosana Moreira de , Matos Tatyana Lós de Melo , Santos Isabele Silva dos , Silva Ana Beatriz Pereira da , Rufino Cleide Gonçalo , Silva Richardson Augusto Rosendo da
Published: August 2023

Objective: To carry out content validity of the statements of International Classification for Nursing Practice (ICNP®) terminology subset diagnoses, outcomes and nursing interventions for people with chronic kidney disease on conservative treatment.

Methods: A methodological study, which followed the Brazilian method guidelines, with content validity conducted by the Delphi technique and carried out with 67 expert nurses. A total of 123 nursing diagnosis/outcome statements and 215 nursing intervention statements, distributed by Callista Roy’s adaptation model of nursing modes were assessed. To assess the degree of agreement regarding the meaning and clinical use among experts, the Content Validity Index (CVI) was used, accepting statements that presented an index ≥ 0.80.
Results

After two Delphi rounds, 117 diagnoses/outcomes and 199 nursing interventions were validated. Of the diagnoses, 70 (60%) were classified in Physiological Mode, 19 (16%) in Self-Concept Mode, 17 (14%) in Real-Life Function Mode, and 11 (10%) in Callista Roy’s Interdependence Mode. Among the most prevalent diagnostic statements were: “Altered Blood Pressure”, “Peripheral Oedema”, “Fluid Retention”, “Lack of Knowledge of Dietary Regime”, “Impaired Adaptation”, “Self-Care Deficit” and “Impaired Access to Treatment”. Valid nursing interventions underwent wording changes.

Conclusion: The development of an ICNP® terminology subset according to the adopted theoretical model proved to be valid in terms of content for the care of people with chronic kidney disease undergoing conservative treatment through clear and directive care plans.
Perancangan Alat Peraga Berbasis Physics Toys Pada Materi Efek Doppler Menggunakan RTC dan Arduino
Authors: Ashari Ashari , Anzani Putri Wira , Pratiwi Umi , Sriyono Sriyono
Published: August 2023

onsep fisika dan besaran pada mata pelajaran Fisika di sekolah dapat disajikan secara realistik melalui serangkaian kegiatan praktikum dan demonstrasi melalui alat peraga pembelajaran. Telah dilakukan perancangan alat peraga berbasis permainan untuk Fisika (physics toys) pada Efek Doppler menggunakan RTC dan Arduino. Metode penelitian mengadaptasi model ADDIE yang terdiri dari Analyze, Design, Development, Implementation, dan Evaluation. Guna mengetahui kelayakan alat peraga dilakukan ujicoba alat dan validasi produk oleh ahli materi Fisika, ahli media, dan guru Fisika di sekolah. Berdasarkan hasil penelitian dihasilkan: (1) produk alat peraga Efek Doppler berbasis Arduino yang berfungsi dengan baik, dengan % eror uji sistem 1 secara manual sebesar 0,005%, dan % eror uji sistem 2 dengan manual sebesar 0,006%. (2) hasil validasi produk diperoleh skor rerata 2,975 dengan kategori cukup baik dengan perolehhan percentage ggreement sebesar 99% (3) Hasil kepraktisan alat diperoleh rerata sebesar 76,5%. Berdasarkan hasil tersebut produk yang dibuat dapat dimanfaatkan sebagai alternatif alat peraga berbasis permainan dalam pembelajaran Fisika.
El tren maya en México: un proyecto contradictorio
Authors: Rosas Candelas Carlos Antonio , Sandoval Forero Eduardo Andrés , Iglesias Piña David , Sánchez Barreto Rafael Fernando
Published: August 2023

El presente documento muestra un análisis sobre la forma en que se ha manejado el tema de la sustentabilidad y la relación con los actores involucrados dentro de las localidades a las que han incorporado por decisión gubernamental el enfoque de desarrollo sustentable como eje para mejorar su calidad de vida, brindando atención según los discursos oficiales en minimizar los impactos medioambientales en sus territorios. Se considera que una de las principales problemáticas encontradas y por las cuales no se gesta un verdadero enfoque sustentable es la nula o escasa integración de los actores involucrados en los procesos de gestión, así como los discursos institucionalizados bajo los cuales se entiende el concepto y filosofía de la “sustentabilidad”, ya que difícilmente las partes interesadas se coordinan bajo un eje transversal para el diseño y aplicación de estrategias acordes a las necesidades de la población así como de los bienes naturales y culturales.
Over de zinvolheid van geweld en de problematisering van religie
Authors: de Koning Martijn
Published: August 2023

Religieuze betekenisgeving doet ertoe, laat Radicale verlossing zien. Maar hoe verhoudt dergelijk werk zich tot een context waarin moslims geproblematiseerd worden op basis van ideeën over islam, politiek en terrorisme?
Pentecostalism, Pilgrimage to Prayer Mountains and Pilgrims’ Adherence to Holiness Ethics in Ghanaian Christianity
Authors: Okyere Philip Kwadwo
Published: August 2023

The influence of Pentecostalism as a global religious culture is obvious in almost every sphere of human endeavour. As a Christian religious category, Pentecostalism permeates virtually all dimensions of Christian faith and practice. In spite of the visibility and vociferous presence of Pentecostalism as a worldwide Christian religious culture, its influence on Christians’ visitation to Prayer Mountains (PMs) and the pilgrims’ devotion to holiness ethics appear not to have been traversed in scholarship. This paper attempts to fill this gap by employing a multidisciplinary approach to gather the relevant field data. The discussion is theoretically anchored on Miroslav Volf’s ‘The Christian Faith as a Prophetic Religion.’ Using this theory as a hermeneutical framework of the influence of pilgrimage to PMs on society, the paper discloses, among others, that Ghanaian Christians’ pilgrimage to PMs and the pilgrims’ adherence to holiness ethics are replications of Pentecostal practices. Keywords: Pentecostalism, pilgrimage, Abasua Prayer Mountain, holiness ethics
A Three-dimensional Model for the Evolution of Magnetohydrodynamic Turbulence in the Outer Heliosphere
Authors: Kleimann Jens , Oughton Sean , Fichtner Horst , Scherer Klaus
Published: August 2023

We present a time-dependent, three-dimensional single-fluid model for the transport of magnetohydrodynamic (MHD) turbulence that is self-consistently evolving with a dynamic large-scale solar wind in the outer heliosphere. The emphasis is on the region beyond the termination shock, where the solar wind expands subsonically, as well as sub-Alfvénically and nonradially. In extension of earlier work, we refine the treatment of turbulence by considering, in addition to the Elsässer energies, a nonconstant energy difference (or residual energy) and by allowing each of these quantities its own characteristic correlation length scale. While the nonlinear effects in the equations for the Elsässer energies and their length scales are implemented using familiar von Kármán–Howarth style modeling of homogeneous MHD turbulence, the energy difference, which is not conserved in the absence of dissipation, and its length scale are modeled using distinct approaches. We also clarify the impact of the choice of measurement direction for correlation functions associated with two-dimensional fluctuations in transport models. Finally, we illustrate and study the solutions of the resulting six-equation model in detail.
Daily activities of water monitors (Varanus salvator macromaculatus Deraniyagala, 1944) in urban wetland, Bangkok, Thailand
Authors: Trivalairat Poramad , Srikosamatara Sompod
Published: August 2023

From July to October 2015, a study was conducted on the water monitors (Varanus salvator macromaculatus) at Dusit Zoo in Bangkok, Thailand. A total of 90 monitors were captured, measured for SVL, sexed, and marked on the right axilla. The captured monitors included 70 females and 20 males, resulting in a sex ratio of 3.5:1. Body size did not differ significantly between genders. The monitors exhibited bimodal diurnal activity, with a focus on fish hunting in the morning (06:00–08:00 h) and scavenging for fish leftovers in the afternoon (15:00–17:00 h). After the monitor lizards hunted for prey in the morning, they spent 5–7 hours basking and floating in the lake during the afternoon. Sexual behaviors were also occasionally observed. The monitors displayed frequent predatory behavior towards natural prey, especially fish, in the morning, as opposed to opportunistically scavenging on tourist food and fish leftovers observed throughout the day.
Integrative taxonomic revision of the genera Nesticella and Howaia in Japan with the description of five new species (Araneae, Nesticidae, Nesticellini)
Authors: Ballarin Francesco , Eguchi Katsuyuki
Published: August 2023

The Japanese species of the genera Nesticella Lehtinen & Saaristo, 1980 and Howaia Lehtinen & Saaristo, 1980 (Araneae, Nesticidae, Nesticellini) are revised using an integrative taxonomic approach. Their morphology, phylogenetic position within the genera, assignment to species groups, and distribution in mainland Japan and the Ryukyu islands are discussed herein. A phylogenetic and species delimitation analysis was conducted to confirm the boundaries between the putative species that were initially discriminated based on external and genital morphology. As a result of the present study, six species of Nesticella and three species of Howaia are proposed for the fauna of Japan based on the combined results of morphology and molecular analyses. Male and female of the previously known species H. mogera (Yaginuma, 1972), N. brevipes (Yaginuma, 1970), and N. okinawaensis (Yaginuma, 1979) are redescribed and illustrated using type specimens or specimens collected at the type locality. Nesticella terrestris (Yaginuma, 1970) is resurrected as a valid species and distinguished from the closely related N. brevipes based on morphological and molecular evidence. The male of N. terrestris is described for the first time. We herein describe three new species of Nesticella and two new species of Howaia from different islands in the Ryukyu Archipelago, southwest Japan: N. insulanasp. nov. (♂, ♀) from Yonaguni-jima Island, N. occultasp. nov. (♀) from Ishigaki-jima Island, N. silvicolasp. nov. (♂, ♀) from Yakushima Island, H. albasp. nov. (♂, ♀) from Miyako-jima Island and H. subterraneasp. nov. (♀) from Okinoerabu-jima Island. Nesticella occultasp. nov., H. albasp. nov. and H. subterraneasp. nov. dwell exclusively in caves and show extensive morphological adaptation to subterranean life.
Improved Yolov5 and Image Morphology Processing Based on UAV Platform for Dike Health Inspection
Authors: Ma Wei , Zhang Pei Chang , Huang Lei , Zhu Jun Wei , Lian Yu Tao , Xiong Jie , Jin Fan
Published: August 2023

Dike health inspection is crucial in river channel regulating. The conventional manual collapse inspection is inefficient and costly so that the unmanned aerial vehicle (UAV)-based inspection has been widely applied. However, the existing vision-based defect detection methods face challenges, such as lack of defect sample data and closed specified data sets. To address them, a defect detection method based on improved YOLOv5 recognition combined with image morphology processing is proposed for dike health inspection with zero defect samples. Specifically, the coordinate attention mechanism is introduced in YOLOv5 model to improve recognition capability for dikes. Also, a rotating bounding box target detection is designed for arbitrary orientation of dikes under UAV view, due to ineffective horizontal bounding box detection. Furthermore, for suspected defect locating efficiency promotion, the specific recognized area of the dike is isolated in the image morphology process. The results show that the proposed method outperforms the traditional Yolov5 algorithm on recall rate, F1, and mAP.
Research on the Impact of Enterprise Innovation and Government Organization Innovation on Regional Collaborative Innovation
Authors: Chu Yingjing , Pang Liyuan , Ayoungman Fairtown Zhou
Published: August 2023

Improving the regional innovation system and developing new organizational innovations to continuously enhance regional innovation capabilities are key measures for building a regional innovation hub and achieving high-quality economic development. This study first theoretically elucidates the impact mechanism of enterprise innovation agglomeration and government policy uncertainty on regional innovation capability, and thus clarifies such impact on regional organizational innovation. Based on urban panel data, this article empirically analyzes their impact on regional innovation. Based on the research results, the agglomeration of manufacturing industry in cities can significantly improve regional innovation capabilities. The policy uncertainty brought about by the mobility of municipal party secretaries has a restraining effect on the enhancement of regional innovation capabilities. The higher the degree of marketization in a city, the more significant the role of manufacturing agglomeration in enhancing regional innovation capabilities, thereby weakening the inhibitory effect of policies.
Chemical Compositions of Essential Oil of Agarwood (Aquilaria crassna) Harvested in Phu Quoc Island, Vietnam
Authors: Toan Tran Quoc , Dinh Thi Thu Thuy , Tran Thi Tuyen , Hoang Thi Bich , Pham Quoc Long , Nguyen Quyet Chien , Quy Nguyen Ngoc , Nguyen Thanh Viet
Published: August 2023

The importance of natural products derived from Agarwood species is increasingly emphasized in the production of perfumery or cosmetic products made on Agarwood species. On the other hand, due to the predominant amount of aromatic compounds in essential oils, frankincense essential oil is increasingly popular with high economic value. Therefore, in this study, we focused on the extraction process of essential oils and evaluated the chemical composition present in the essential oils by the GC-MS method. Differences in the composition of essential oils between natural and artificial agarwood may be due to species, habitat conditions, climate, geographical conditions, and extraction methods in different regions. Specifically, volatile components in essential oils were identified as Neopetasone (14.43%); Dihydroagarofuran-15-al (9.20%); Jinko-cramol (5.02%); Valeriano (4.94%); Agarofuran  (8.02%); Dihydrokaranone (3.25%), Valenca-1 (10), 8-dien-11-ol (5.95%) and Selina-4,11-dien-14-al (2.73%), contribute to determining the main aroma in Agarwood essential oil.
Effectiveness of Progressive Muscle Relaxation Therapy on Pregnancy Outcomes among Stressed and Anxious Primigravida Antenatal Mothers: A Randomized Controlled Trial
Authors: Nishshanka N. M. C. L. , Goonewardena C. S. E. , Kasturiarachchi S. K. , Waas M. D. I. A. , Kulathunga K. A. C. J. R. , Gamagedara N. S.
Published: August 2023

Background: Progressive muscle relaxation therapy is an anxiety and stress reducing method. Anxiety and stress during antenatal period cause many adverse effects on pregnancy outcomes; therefore require early screening and management of those conditions to improve pregnancy outcomes. Objective: Our objective was to evaluate effectiveness of progressive muscle relaxation therapy in improving pregnancy outcomes among primigravida mothers in Badulla district. Methods: A community-based cluster randomized controlled trial was conducted among 288 primigravida mothers in latter stage of second trimester who screened to have anxiety or stress or both by Depression Anxiety Stress Scale-21 (DASS-21). 144 primigravida mothers were recruited to each intervention and control arms from six selected Medical Officer of Health areas in Badulla district. Pregnancy outcomes were compared in both arms at one month post-partum by calculating Pearson’s correlation coefficient.Results: Pregnancy outcomes at one month post-partum showed significant differences in the control arm compared to the intervention arm; in caesarean section or assisted vaginal delivery (OR = 2.44; 95% CI = 1.34, 4.46), delivery of baby before 37 weeks of gestation (OR = 2.35; 95% CI = 1.31, 4.21), prolong labour (OR = 4.93; 95% CI = 1.05, 23.27) and experienced post-natal complications in babies (OR = 2.12; 95% CI = 1.03, 4.35).Conclusions: Progressive muscle relaxation therapy was effective in improving pregnancy outcomes in primigravida mothers.
Obstetrics Quiz
Authors: Dias Tiran
Published: August 2023

No abstract available
IL-33 Orchestrated the Interaction and Immunoregulatory Functions of Alternatively Activated Macrophages and Regulatory T Cells In Vitro
Authors: Mok Mo Yin , Luo Cai Yun , Huang Fang Ping , Kong Wing Yin , Chan Godfrey Chi Fung
Published: August 2023

Our group has previously demonstrated elevated serum-soluble ST2 in patients with active systemic lupus erythematosus, suggesting a role of IL-33 in the underlying pathogenesis. However, inconsistent results have been reported on the effect of exogenous IL-33 on murine lupus activity, which may be mediated by concerted actions of various immune cells in vivo. This study aimed to examine the function of IL-33 on macrophage polarization and regulatory T cells (Treg) and their interactive effects in the lupus setting by in vitro coculture experiments of macrophages and T cells that were performed in the presence or absence of IL-33–containing medium. Compared to IL-4–polarized bone marrow–derived macrophages (BMDM) from MRL/MpJ mice, adding IL-33 enhanced mRNA expression of markers of alternatively activated macrophages, including CD206 and Arg1. IL-33 and IL-4 copolarized BMDM produced higher TGF-β but not IL-6 upon inflammatory challenge. These BMDM induced an increase in the Foxp3+CD25+ Treg population in cocultured allogeneic T cells from MRL/MpJ and predisease MRL/lpr mice. These copolarized BMDM also showed an enhanced suppressive effect on T cell proliferation with reduced IFN-γ and IL-17 release but increased TGF-β production. In the presence of TGF-β and IL-2, IL-33 also directly promoted inducible Treg that expressed a high level of CD25 and more sustained Foxp3. Unpolarized BMDM cocultured with these Treg displayed higher phagocytosis. In conclusion, TGF-β was identified as a key cytokine produced by IL-4 and IL-33 copolarized alternatively activated macrophages and the induced Treg, which may contribute to a positive feedback loop potentiating the immunoregulatory functions of IL-33.
Blastic plasmacytoid dendritic cell neoplasm: a short review and update
Authors: Massone Cesare , Rivoli Giulia , Sola Simona , Angelucci Emanuele
Published: August 2023

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is a rare hematologic neoplasm (less than 1% of primary cutaneous lymphomas and acute leukemia) with a highly aggressive clinical course and frequent skin, bone marrow and central nervous system (CNS) involvement. Despite a frequent initial response to chemotherapy, relapses with eventual leukemic dissemination are extremely common, leading to poor outcomes and a median overall survival (OS) ranging from 8 to 14 months in first line setting, with standard combination chemotherapy regimens. The skin is the first affected site (in almost 90% of patients) where BPDCN may remain confined for weeks or even months (sanctuary?) until a rapid second step with multiorgan involvement occurs. Therefore, it is of uppermost importance to suspect and recognize early skin lesions and to perform and report a skin biopsy as soon as possible. A multidisciplinary approach with coordination among dermatologists, pathologists and hematologists is definitively crucial in diagnosis and management of BPDCN.
Deep mycosis mimicking cutaneous squamous cell carcinoma
Authors: Cassalia Fortunato , Gratteri Francesco , Azzi Leonardo , Tosi Anna L. , Giordani Mauro
Published: August 2023

Deep cutaneous mycoses are fungal infections that affect the skin and its deeper layers, leading to significant morbidity if not promptly diagnosed and treated. While dermatophytes, particularly Trichophyton rubrum and Trichophyton mentagrophytes, are the most common causative agents, other fungi such as Candida spp., Aspergillus spp., and Fusarium spp. can also cause these infections, especially in immunocompromised individuals. The clinical presentation varies depending on the depth and extent of the infection, ranging from superficial erythematous lesions to firm subcutaneous nodules, ulcers, abscesses, or sinus tracts. In advanced cases, deep cutaneous mycoses can lead to osteomyelitis and bone destruction. Mycetoma, a chronic infectious disease affecting the skin, subcutaneous tissues, and bones, is considered a deep skin mycosis. It is endemic in certain regions and can mimic other conditions such as cutaneous tuberculosis or cancerous lesions, making accurate diagnosis challenging. Diagnosis typically involves clinical presentation, radiological findings, and microbiological culture, with molecular methods aiding in culture-negative cases. Treatment is challenging and may involve surgical debridement, antifungal/antibiotic therapy, and sometimes amputation. Prevention strategies include improving hygiene, raising awareness, and early diagnosis. We present a case of an immunocompetent farmer with a wrist lesion initially suspected as cutaneous squamous cell carcinoma but histologically diagnosed as eumycetoma, emphasizing the importance of considering deep mycoses in high-risk individuals and highlighting the heterogeneous clinical presentation of these infections.
Iron metabolism and peripheral eosinophil count do not correlate in the general population
Authors: De Amici Mara , Albertini Riccardo , Barocci Fiorella , Bosoni Tiziana , Ciardelli Laura Maria , De Silvestri Annalisa , Marseglia Gian Luigi , Ciprandi Giorgio
Published: August 2023

Iron is a primary component of the human body and exerts many functions, mainly concerning red cells and the immune system. In addition, there is evidence that iron-deficiency anemia is associated with allergic diseases. Type 2 inflammation characterizes allergic diseases. Peripheral eosinophils are a reliable biomarker for type 2 inflammation. Therefore, the present study investigated the possible relationship between iron metabolism and peripheral eosinophils in a large population. Eosinophils also play important roles in immune and tissue homeostasis. A growing body of data suggests tissue eosinophils represent a plastic and heterogeneous population of functional sub-phenotypes, shaped by environmental (systemic and local) factors. The retrospective study included 2795 subjects who were afferent to the Clinical Chemistry Analysis Laboratory during the year 2022. Men had higher peripheral eosinophil count than women (p<0.001). Furthermore, stratifications for sex, eosinophil, and hemoglobin cut-offs showed that men had more eosinophil counts than women. However, there was no correlation between iron biomarkers and peripheral eosinophils. The present study did not demonstrate a clear relationship between iron deficiency and peripheral eosinophil count. Even if this large population may include allergic subjects and patients with different diseases, it seems that iron does not directly affect eosinophil count.
Star power: harnessing the reactive astrocyte response to promote remyelination in multiple sclerosis
Authors: Junior Markley Silva Oliveira , Reiche Laura , Daniele Emerson , Kortebi Ines , Faiz Maryam , Küry Patrick
Published: August 2023

Astrocytes are indispensable for central nervous system development and homeostasis. In response to injury and disease, astrocytes are integral to the immunological- and the, albeit limited, repair response. In this review, we will examine some of the functions reactive astrocytes play in the context of multiple sclerosis and related animal models. We will consider the heterogeneity or plasticity of astrocytes and the mechanisms by which they promote or mitigate demyelination. Finally, we will discuss a set of biomedical strategies that can stimulate astrocytes in their promyelinating response.
Dual-directional regulation of spinal cord injury and the gut microbiota
Authors: Cui Yinjie , Liu Jingyi , Lei Xiao , Liu Shuwen , Chen Haixia , Wei Zhijian , Li Hongru , Yang Yuan , Zheng Chenguang , Li Zhongzheng
Published: August 2023

There is increasing evidence that the gut microbiota affects the incidence and progression of central nervous system diseases via the brain-gut axis. The spinal cord is a vital important part of the central nervous system; however, the underlying association between spinal cord injury and gut interactions remains unknown. Recent studies suggest that patients with spinal cord injury frequently experience intestinal dysfunction and gut dysbiosis. Alterations in the gut microbiota can cause disruption in the intestinal barrier and trigger neurogenic inflammatory responses which may impede recovery after spinal cord injury. This review summarizes existing clinical and basic research on the relationship between the gut microbiota and spinal cord injury. Our research identified three key points. First, the gut microbiota in patients with spinal cord injury presents a key characteristic and gut dysbiosis may profoundly influence multiple organs and systems in patients with spinal cord injury. Second, following spinal cord injury, weakened intestinal peristalsis, prolonged intestinal transport time, and immune dysfunction of the intestine caused by abnormal autonomic nerve function, as well as frequent antibiotic treatment, may induce gut dysbiosis. Third, the gut microbiota and associated metabolites may act on central neurons and affect recovery after spinal cord injury; cytokines and the Toll-like receptor ligand pathways have been identified as crucial mechanisms in the communication between the gut microbiota and central nervous system. Fecal microbiota transplantation, probiotics, dietary interventions, and other therapies have been shown to serve a neuroprotective role in spinal cord injury by modulating the gut microbiota. Therapies targeting the gut microbiota or associated metabolites are a promising approach to promote functional recovery and improve the complications of spinal cord injury.
Dual-targeting AAV9P1-mediated neuronal reprogramming in a mouse model of traumatic brain injury
Authors: Liu Jingzhou , Xin Xin , Sun Jiejie , Fan Yueyue , Zhou Xun , Gong Wei , Yang Meiyan , Li Zhiping , Wang Yuli , Yang Yang , Gao Chunsheng
Published: August 2023

JOURNAL/nrgr/04.03/01300535-202403000-00038/inline-graphic1/v/2023-09-27T141015Z/r/image-tiff

Traumatic brain injury results in neuronal loss and glial scar formation. Replenishing neurons and eliminating the consequences of glial scar formation are essential for treating traumatic brain injury. Neuronal reprogramming is a promising strategy to convert glial scars to neural tissue. However, previous studies have reported inconsistent results. In this study, an AAV9P1 vector incorporating an astrocyte-targeting P1 peptide and glial fibrillary acidic protein promoter was used to achieve dual-targeting of astrocytes and the glial scar while minimizing off-target effects. The results demonstrate that AAV9P1 provides high selectivity of astrocytes and reactive astrocytes. Moreover, neuronal reprogramming was induced by downregulating the polypyrimidine tract-binding protein 1 gene via systemic administration of AAV9P1 in a mouse model of traumatic brain injury. In summary, this approach provides an improved gene delivery vehicle to study neuronal programming and evidence of its applications for traumatic brain injury.
CD68 and CD163 expressions can predict high grade and spread in breast carcinoma
Authors: Abdelaziz Solafa A. , Hussein Mahmoud T. El-Sabah , Hamza Maya M. , Mahmoud Marwa M.
Published: August 2023

Objectives

This study aimed to assess the immunohistochemical (IHC) expression of tumor-associated macrophage CD68 and CD163 markers in the tumor microenvironment of breast carcinoma and to detect their possible roles in the prognosis of this tumor.

Patients and methods

A retrospective study was carried out on 40 patients diagnosed with breast carcinoma over a 1-year time period from January 2019 to January 2020. The cases were randomly selected as archival paraffin blocks from the Pathology Departments of Kasr Al-Ainy Hospital and Misr University for Science and Technology. Hematoxylin and eosin-stained slides were used to revise the diagnosis and to assess the histopathological features of the tumors. IHC slides were prepared using monoclonal antibodies against macrophage markers CD68 and CD163 to evaluate their expressions. The relations between the results of IHC staining and the collected clinicopathologic data were tabulated and statistically analyzed.

Results

This study included a total of 40 patients with breast carcinoma. The age of the patients ranged from 20 and 68 years, with a mean age of 49.08 years (±12.11). Twenty six (65%) patients had invasive duct carcinoma, 12 (30%) patients had invasive lobular carcinoma, and two (5%) patients had mixed ductal and lobular carcinoma. CD68 expression was positive in 30 (75%) patients and CD163 expression was positive in 17 (42.5%) patients. Statistically significant correlations were detected between grade III tumors, lymph node metastasis, lymphovascular or perineural invasions, and the expressions of macrophage markers CD68 and CD163.

Conclusion

The synergetic effects of both types of macrophage markers CD68 and CD163 indicate worse prognosis in breast carcinoma as clarified by the significant correlation of both markers with high-grade tumors, lymph node metastasis, and lymphovascular or perineural invasions.
Immunohistochemical expression and prognostic value of epidermal growth factor receptor 1 and human epidermal growth factor receptor 2/neu in primary colorectal carcinoma
Authors: Bebars Shaimaa M.M. , Mohammed Hala S.A. , Osman Ghada S. , Sakr Mona A.
Published: August 2023

Objectives

Colorectal carcinoma (CRC), a highly heterogeneous disease, is the seventh most common cancer in Egypt. Human epidermal growth factor receptor 1 (EGFR1) and human epidermal growth factor receptor 2 (HER2/neu) are biomarkers that have been introduced recently for patient stratification, prediction of prognosis, and implementation of personalized therapy. Therefore, this study aimed to investigate the immunohistochemical expression of EGFR1 and HER2/neu in primary CRC patients and their relations with clinicopathological parameters and overall survival (OS).

Patients and methods

Sixty-six patients with primary CRC from the National Cancer Institute of Egypt were enrolled in this study. Paraffin blocks were collected and sectioned for histopathological evaluation. Other sections were stained using anti-EGFR1 and anti-HER2/neu monoclonal antibodies.

Results

Cytoplasmic and membranous EGFR1 was expressed in 81.8% of cases, while complete membranous HER2/neu-positive staining (>10% of tumor cells) was detected in 2/3 of cases. The EGFR1 expression was significantly associated with advanced stage and positive lymph node status. None of the other parameters, including overall survival, showed a significant relation with the expression of both markers.

Conclusion

In conclusion, EGFR1 and HER2/neu proteins were highly expressed in the CRC cases investigated. EGFR1 expression was significantly associated with indicators of poor prognosis (advanced tumor stage and nodal positivity). Both markers showed a tendency toward worse survival.