bluuebunny/crossref_metadata_2025 huggingface dataset:
Maternal Fiber Dietary Intakes during Pregnancy and Infant Allergic Disease
Authors: Pretorius Rachelle A. , Bodinier Marie , Prescott Susan L. , Palmer Debra J.
Published: August 2019

Maternal diet during pregnancy plays a likely role in infant immune development through both direct nutrient specific immunomodulatory effects and by modulating the composition and metabolic activity of the maternal gut microbiome. Dietary fibers, as major substrates for microbial fermentation, are of interest in this context. This is the first study to examine maternal intakes of different fiber sub-types and subsequent infant allergic disease. In an observational study of 639 mother–infant pairs (all infants had a family history of allergic disease) we examined maternal intakes of total fiber, soluble fiber, insoluble fiber, resistant starch, and prebiotic fiber, by a semi-quantitative food frequency questionnaire at 36–40 weeks’ gestation. Infants attended an allergy clinical assessment at 12 months of age, including skin prick testing to common allergens. Higher maternal dietary intakes of resistant starch were associated with reduced doctor diagnosed infant wheeze, adjusted odds ratio (aOR) 0.68 (95% CI 0.49, 0.95, p = 0.02). However, in contrast, higher maternal intakes of resistant starch were associated with higher risk of parent reported eczema aOR 1.27 (95% CI 1.09, 1.49, p < 0.01) and doctor diagnosed eczema aOR 1.19 (95% CI 1.01, 1.41, p = 0.04). In conclusion, maternal resistant starch consumption was differentially associated with infant phenotypes, with reduced risk of infant wheeze, but increased risk of eczema.
An In Vivo (Gallus gallus) Feeding Trial Demonstrating the Enhanced Iron Bioavailability Properties of the Fast Cooking Manteca Yellow Bean (Phaseolus vulgaris L.)
Authors: Wiesinger Jason A. , Glahn Raymond P. , Cichy Karen A. , Kolba Nikolai , Hart Jonathan J. , Tako Elad
Published: August 2019

The common dry bean (Phaseolus vulgaris L.) is a globally produced pulse crop and an important source of micronutrients for millions of people across Latin America and Africa. Many of the preferred black and red seed types in these regions have seed coat polyphenols that inhibit the absorption of iron. Yellow beans are distinct from other market classes because they accumulate the antioxidant kaempferol 3-glucoside in their seed coats. Due to their fast cooking tendencies, yellow beans are often marketed at premium prices in the same geographical regions where dietary iron deficiency is a major health concern. Hence, this study compared the iron bioavailability of three faster cooking yellow beans with contrasting seed coat colors from Africa (Manteca, Amarillo, and Njano) to slower cooking white and red kidney commercial varieties. Iron status and iron bioavailability was assessed by the capacity of a bean based diet to generate and maintain total body hemoglobin iron (Hb-Fe) during a 6 week in vivo (Gallus gallus) feeding trial. Over the course of the experiment, animals fed yellow bean diets had significantly (p ≤ 0.05) higher Hb-Fe than animals fed the white or red kidney bean diet. This study shows that the Manteca yellow bean possess a rare combination of biochemical traits that result in faster cooking times and improved iron bioavailability. The Manteca yellow bean is worthy of germplasm enhancement to address iron deficiency in regions where beans are consumed as a dietary staple.
Health Effects of Phenolic Compounds Found in Extra-Virgin Olive Oil, By-Products, and Leaf of Olea europaea L.
Authors: Romani Annalisa , Ieri Francesca , Urciuoli Silvia , Noce Annalisa , Marrone Giulia , Nediani Chiara , Bernini Roberta
Published: August 2019

Olea europaea L. fruit is a peculiar vegetal matrix containing high levels of fatty acids (98–99% of the total weight of extra-virgin olive oil, EVOO) and low quantities (1–2%) of phenolics, phytosterols, tocopherols, and squalene. Among these minor components, phenolics are relevant molecules for human health. This review is focused on their beneficial activity, in particular of hydroxytyrosol (HT), oleuropein (OLE), oleocanthal (OLC), and lignans found in EVOO, olive oil by-products and leaves. Specifically, the cardioprotective properties of the Mediterranean diet (MD) related to olive oil consumption, and the biological activities of polyphenols recovered from olive oil by-products and leaves were described. Recent European projects such as EPIC (European Prospective Investigation into Cancer and Nutrition) and EPICOR (long-term follow-up of antithrombotic management patterns in acute coronary syndrome patients) have demonstrated the functional and preventive activities of EVOO showing the relation both between cancer and nutrition and between consumption of EVOO, vegetables, and fruit and the incidence of coronary heart disease. The data reported in this review demonstrate that EVOO, one of the pillars of the MD, is the main product of Olea europaea L. fruits; leaves and by-products are secondary but precious products from which bioactive compounds can be recovered by green technologies and reused for food, agronomic, nutraceutical, and biomedical applications according to the circular economy strategy.
Phaseolus vulgaris L. Extract: Alpha-Amylase Inhibition against Metabolic Syndrome in Mice
Authors: Micheli Laura , Lucarini Elena , Trallori Elena , Avagliano Carmen , De Caro Carmen , Russo Roberto , Calignano Antonio , Ghelardini Carla , Pacini Alessandra , Di Cesare Mannelli Lorenzo
Published: August 2019

To examine the effects of the alpha-amylase inhibitor isoform 1 called phaseolamin, a standardized extract from white kidney beans (Phaseolus vulgaris L.) was tested against the hallmarks of metabolic syndrome. The efficacy of a per os repeated treatment with P. vulgaris extract (500 mg/kg) was compared with metformin (100 mg/kg) and atorvastatin (10 mg/kg) in a model of metabolic syndrome evoked by prolonged high fat diet (HFD; week 1 to week 19) in C57BL/6 mice. Bean extract and compounds administration started after metabolic syndrome establishment (week 11). P. vulgaris extract reduced the body weight overtime, as well as effectively lowered glycaemia, triglycerides, and cholesterol. On week 19, bean extract normalized the HFD-evoked tolerance to glucose and insulin. According to the phytochemical characterization, it inhibited the alpha-amylase activity. Animals treated with the extract were rescued from motor impairments and nociceptive threshold alterations induced by HFD. Specific organs analysis revealed that P. vulgaris extract decreased hepatic steatosis and lipid peroxidation in liver. It protected the heart from HFD oxidative alterations increasing the expression of the detoxifying enzymes catalase and glutathione reductase, and normalizing NADH dehydrogenase level. The histological analysis of aorta showed a protection about the development of fatty streaks in the muscular layers. In conclusion, a prolonged treatment with the standardized extract of P. vulgaris significantly reduced several pathological features related to a metabolic syndrome-like condition; a multifactorial approach that candidates this vegetal product as a possible therapeutic option against metabolic syndrome.
Melon GliSODin® Prevents Diet-Induced NASH Onset by Reducing Fat Synthesis and Improving Liver Function
Authors: Nakamura Anna , Kitamura Naho , Yokoyama Yoko , Uchida Sena , Kumadaki Kayo , Tsubota Kazuo , Watanabe Mitsuhiro
Published: August 2019

A high-calorie diet causes fat accumulation and oxidative stress in the liver, leading to fatty liver and eventually non-alcoholic steatohepatitis (NASH). Melon GliSODin® is used as a nutritional supplement because of its antioxidant activity. This study aimed to assess the antioxidant activity of Melon GliSODin® and its effectiveness in preventing NASH, which primarily results from oxidative stress. Furthermore, we verified the protective effect of Melon GliSODin® by administering it to a mouse model of diet-induced NASH. Melon GliSODin® suppressed liver fibrosis and fat accumulation, which is characteristic of the NASH phenotype. Gene expression analysis confirmed the suppression of fat synthesis and activation of antioxidative mechanisms. These results show that Melon GliSODin® mitigates NASH onset at the molecular level, suggesting its potential application as a NASH preventive agent.
Selenium as a Protective Agent against Pests: A Review
Authors: Mechora Špela
Published: August 2019

The aim of the present review is to summarize selenium’s connection to pests. Phytopharmaceuticals for pest control, which increase the pollution in the environment, are still widely used nowadays regardless of their negative characteristics. The use of trace elements, including selenium, can be an alternative method of pest control. Selenium can repel pests, reduce their growth, or cause toxic effects while having a positive effect on the growth of plants. In conclusion, accumulated selenium protects plants against aphids, weevils, cabbage loopers, cabbage root flies, beetles, caterpillars, and crickets due to both deterrence and toxicity.
In Situ Synthesis of Au Nanoparticles on Viscose Cellulose Sponges for Antibacterial Activities
Authors: Shan Mingjing , Liu Chang , Shi Lei , Zhang Lei , Lin Yuan , Zhang Shuo , Zhu Zhenjun , Wang Xiaoyin , Zhuang Xupin
Published: August 2019

Antibacterial viscose cellulose sponges (VCSs) were fabricated by heating cellulose xanthogenate (viscose) containing HAuCl4·nH2O. Viscose was used as the reducing agent and stabilizer for the in situ synthesis of Au nanoparticles (AuNPs) onto the VCSs. The morphology, structures, thermal properties, mechanical performance, and antibacterial activities of the sponges were investigated. Results indicate that AuNPs were uniformly immobilized in the VCSs, and the resulting complexes (AuNPs@VCSs) showed enhanced thermal stability and mechanical properties. Additionally, the AuNPs@VCSs exhibited remarkable antibacterial activities, with zone of inhibition diameter of 35.7 and 37.1 mm for Staphylococcus aureus and Escherichia coli, respectively. The process is simple and applicable at the industrial level and can be applied to the fields of cleaning and sanitation.
Improving Coal Flotation by Gaseous Collector Pretreatment Method and its Potential Application in Preparing Coal Water Slurry
Authors: Shen Liang , Min Fanfei , Liu Lingyun , Xue Changguo , Zhu Jinbo
Published: August 2019

Low-rank coal is difficult to upgrade using conventional flotation methods due to its high hydrophilic properties. Thus, it is necessary to explore new methods for upgrading and utilizing low-rank coal. In this investigation, a gaseous dodecane pretreatment method was used to enhance the flotation performance of low-rank coal. Pore distribution analysis, FTIR (Fourier Transform Infrared Spectroscopy), and contact angle measurements were used to study the surface properties of the coal sample. Size distribution and float-sink test results indicated that the coal sample contained a lot of clean coal with low ash content, which could be used as a high quality raw material for making coal water slurry. FTIR, pore distribution analysis, and contact angle results showed that the coal was very hydrophilic due to the high concentration of -OH group and the large number of pores and cracks on the coal surface. The hydrophobicity of the coal sample was significantly improved by the gaseous dodecane pretreatment method. Clean coal with 67.2% combustible matter recovery and 10.5% ash content was obtained by gaseous dodecane pretreatment flotation method. Coal water slurry with 60% concentration was prepared using the flotation clean coal.
Intra-Aortic Balloon Pump for Patients with Cardiac Conditions: An Update on Available Techniques and Clinical Applications
Authors: Limbert Vanessa M. , Amiri Amir M.
Published: August 2019

In this paper, we present a review of the intra-aortic balloon pump, as well as the usage of it in the medical field today. An intra-aortic balloon pump (IABP) is a biomedical device that can assist the heart during unstable angina or after a heart attack. This pump is typically used in patients who suffer from ischemia of the heart tissue, due to an unbalanced level of myocardial oxygen supply or demand. Through counterpulsation, which is a technique to synchronize the external pumping of blood with the heart’s cycle, the device can balance the supply and demand of blood that is necessary for the heart to pump properly. The IABP is comprised of the following four components: a polyurethane balloon, a polyethylene or fiber-optic catheter, a transducer, and the intra-aortic balloon pump console. In the past, researchers have used other materials that have low biocompatibility and can cause complications within the body. This analysis will explain the complications and state changes that occurred due to them. Limitations of past designs and advantages of current designs will be acknowledged, for they can be used by researchers to enhance designs for the future. Consequently, the analysis of this device may lead to improved designs and treatment in the future for patients with cardiac conditions.
Comparison of Tropospheric Path Delay Estimates from GNSS and Space-Borne SAR Interferometry in Alpine Conditions
Authors: Wilgan Karina , Siddique Muhammad , Strozzi Tazio , Geiger Alain , Frey Othmar
Published: August 2019

We compare tropospheric delays from Global Navigation Satellite Systems (GNSS) and Synthetic Aperture Radar (SAR) Interferometry (InSAR) in a challenging mountainous environment in the Swiss Alps, where strong spatial variations of the local tropospheric conditions are often observed. Tropospheric delays are usually considered to be an error for both GNSS and InSAR, and are typically removed. However, recently these delays are also recognized as a signal of interest, for example for assimilation into numerical weather models or climate studies. The GNSS and InSAR are techniques of complementary nature, as one has sparse spatial but high temporal resolution, and the other very dense spatial coverage but repeat pass of only a few days. This raises expectations for a combination of these techniques. For this purpose, a comprehensive comparison between the techniques must be first performed. Due to the relative nature of InSAR estimates, we compare the difference slant tropospheric delays ( d S T D ) retrieved from GNSS with the d S T D s estimated using Persistent Scatterer Interferometry (PSI) of 32 COSMO-SkyMed SAR images taken in a snow-free period from June to October between 2008 and 2013. The GNSS estimates calculated at permanent geodetic stations are interpolated to the locations of persistent scatterers using an in-house developed least-squares collocation software COMEDIE. The Pearson’s correlation coefficient between InSAR and GNSS estimates averaged over all acquisitions is equal to 0.64 and larger than 0.8 for approximately half of the layers. Better agreement is obtained mainly for days with high variability of the troposphere (relative to the tropospheric conditions at the time of the reference acquisition), expressed as standard deviations of the GNSS-based d S T D s. On the other hand, the most common feature for the days with poor agreement is represented by very stable, almost constant GNSS estimates. In addition, there is a weak correlation between the agreement and the water vapor values in the area, as well as with the number of stations in the closest vicinity of the study area. Adding low-cost L-1 only GPS stations located within the area of the study increases the biases for most of the dates, but the standard deviations between InSAR and GNSS decrease for the limited area with low-cost stations.
Regression Model to Evaluate the Impact of Basic Sanitation Services in Households and Schools on Child Mortality in the Municipalities of the State of Alagoas, Brazil
Authors: Cavalcanti Alvaro , Teixeira Arthur , Pontes Karen
Published: August 2019

The aim of this article is to measure the impact of basic sanitation services on the mortality rate of children under five years of age (U5MR) in the municipalities of the State of Alagoas, Brazil. A multivariate multiple linear regression model was applied for all 102 cities of Alagoas for data years 1991, 2000 and 2010. The research findings are evidence that access to basic sanitation services in the municipalities of the State of Alagoas, especially household sanitary sewage, is associated with a statistically significant reduction of U5MR, p   <   0.01 . The estimates show that the 10% increase in access to household sanitary sewage is associated to a reduction of 5.7 deaths per 1000 born alive (BA). Based on a simulation of universal basic access sanitation services in the municipalities of the State of Alagoas, it is observed that only this public policy would be able to reduce child mortality by more than 94%. The end results of this study are important subsidies to guide basic sanitation policies not only in the State of Alagoas, Brazil, but also in developing regions all over the world, considering the evidences of social and environmental impact.
Achieving Corporate Sustainability: Toward a Practical Theory
Authors: Kantabutra Sooksan
Published: August 2019

The present study aims at exploring processual relationships between corporate sustainability predictors and sustainability performance, as informed by the Thai philosophy of Sufficiency Economy, and accordingly proposes a theory of corporate sustainability to fill in the fundamental gap in the literature. Based on a framework derived from the literature, multi-data collection methods and the framework approach to qualitative data analysis are adopted to explore the relationships at a sustainable enterprise in Thailand. Findings reveal six processual relationships leading to improving corporate sustainability performance directly and indirectly. Grounded upon seven established theories, the existing empirical literature and the findings of the present study, a coherent theory of corporate sustainability is developed to inform future theory building and guide future corporate sustainability research. Managerial implications and future research directions are discussed.
Mineral Carbonation as an Educational Investigation of Green Chemical Engineering Design
Authors: Fantucci Hugo , Sidhu Jaspreet S. , Santos Rafael M.
Published: August 2019

Engaging students in the experimental design of “green” technology is a challenge in Chemical Engineering undergraduate programs. This concept paper demonstrates an educational methodology to investigate accelerated mineral carbonation, which is a promising technology related to mitigation of climate change by sequestering carbon dioxide (CO2) from industrial sources as stable solid carbonates. An experimental investigation is conceived, whereby students test the effect of two process parameters (CO2 pressure and mixing rate) on the extent of carbonation reaction. The carbonation reaction has been performed using a mineral called wollastonite (CaSiO3). The experimental study and laboratory report cover principles of reaction kinetics and mass transfer, while illustrating the steps to develop and investigate a green process technology. The results from the experimental investigation, which is carried out by multiple teams of students, are then pooled and used to guide a subsequent design project. Students would conceive a flowsheet, size equipment, and estimate the energy demand and net CO2 sequestration efficiency of a full-scale implementation of the mineral carbonation technology. This educational investigation aims to help undergraduate students to acquire deeper experiential learning and greater awareness of future green technologies by applying fundamental engineering principles into an engaging experimental and design exercise.
Investigating Political Risk Paths in International High-Speed Railway Projects: The Case of Chinese International Contractors
Authors: Chang Tengyuan , Deng Xiaopeng , Hwang Bon-Gang
Published: August 2019

Contracting in international high-speed railway (HSR) projects is a risky business. The success of these projects and the sustainable development of international contractors are inseparable from effective risk management. However, limited research has been conducted to investigate the political risk involved in international HSR projects. As HSR development is becoming a more major part of the global construction market, this paper investigates the political risk factors specific to the projects and the relationships among the factors. Through a literature review and a pilot interview conducted with five Chinese professionals, 26 political risk factors were proposed. A questionnaire was then administered to 112 experts from both academia and industry to assess the significance of the factors. By applying partial least-squares structural equation modeling (PLS-SEM) technology, the 26 factors were clustered into eight groups, and 10 significant risk paths were identified. Specifically, “government attitudes” can directly influence the “investment profile” and “social support” can directly influence “government attitudes,” while “government instability,” “economic climate,” “financing and costs,” “external interference,” and “contractors’ operations” can indirectly influence investment profile by directly influencing “government attitudes” or “social support.” The findings of this study can assist international contractors with gaining a clear understanding of the political risk involved in international HSR projects, which will lead to more effective political risk management as well as better business decisions. Furthermore, this paper will contribute to the global body of knowledge in the area of political risk management for large-scale international projects.
Tight-Binding Modeling of Nucleic Acid Sequences: Interplay between Various Types of Order or Disorder and Charge Transport
Authors: Lambropoulos Konstantinos , Simserides Constantinos
Published: August 2019

This review is devoted to tight-binding (TB) modeling of nucleic acid sequences like DNA and RNA. It addresses how various types of order (periodic, quasiperiodic, fractal) or disorder (diagonal, non-diagonal, random, methylation et cetera) affect charge transport. We include an introduction to TB and a discussion of its various submodels [wire, ladder, extended ladder, fishbone (wire), fishbone ladder] and of the process of renormalization. We proceed to a discussion of aperiodicity, quasicrystals and the mathematics of aperiodic substitutional sequences: primitive substitutions, Perron–Frobenius eigenvalue, induced substitutions, and Pisot property. We discuss the energy structure of nucleic acid wires, the coupling to the leads, the transmission coefficients and the current–voltage curves. We also summarize efforts aiming to examine the potentiality to utilize the charge transport characteristics of nucleic acids as a tool to probe several diseases or disorders.
Novel Tick Phlebovirus Genotypes Lacking Evidence for Vertebrate Infections in Anatolia and Thrace, Turkey
Authors: Emanet Nergis , Kar Sırrı , Dinçer Ender , Brinkmann Annika , Hacıoğlu Sabri , Farzani Touraj Aligholipour , Koçak Tufan Zeliha , Polat Pelin Fatoş , Şahan Adem , Özkul Aykut , Nitsche Andreas , Linton Yvonne-Marie , Ergünay Koray
Published: August 2019

We screened ticks and human clinical specimens to detect and characterize tick phleboviruses and pathogenicity in vertebrates. Ticks were collected at locations in Istanbul (Northwest Anatolia, Thrace), Edirne, Kırklareli, and Tekirdağ (Thrace), Mersin (Mediterranean Anatolia), Adiyaman and Şanlıurfa (Southeastern Anatolia) provinces from 2013–2018 and were analyzed following morphological identification and pooling. Specimens from individuals with febrile disease or meningoencephalitic symptoms of an unknown etiology were also evaluated. The pools were screened via generic tick phlebovirus amplification assays and products were sequenced. Selected pools were used for cell culture and suckling mice inoculations and next generation sequencing (NGS). A total of 7492 ticks were screened in 609 pools where 4.2% were positive. A phylogenetic sequence clustering according to tick species was observed. No human samples were positive. NGS provided near-complete viral replicase coding sequences in three pools. A comprehensive analysis revealed three distinct, monophyletic virus genotypes, comprised of previously-described viruses from Anatolia and the Balkans, with unique fingerprints in conserved amino acid motifs in viral replicase. A novel tick phlebovirus group was discovered circulating in the Balkans and Turkey, with at least three genotypes or species. No evidence for replication in vertebrates or infections in clinical cases could be demonstrated.
Guía para la elaboración de las citas y referencias bibliográficas según las Normas Vancouver para los trabajos de investigación en la Universidad Santa Paula
Authors: Bermúdez Ruiz Jose , Benavides Lara Adriana
Published: August 2019

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Cuidados paliativos perinatales, una necesidad real de los servicios de ginecobstetricia y neonatología
Authors: Aguilar Corrales Adriana , Araya Padilla Diana , Cruz Solano Andreína
Published: August 2019

Introducción: Ante el creciente impacto de las anomalías congénitas incompatibles con la vida y las condiciones perinatales que resultan en muertes fetales, se realizó una revisión bibliográfica en torno al tema de los Cuidados Paliativos Perinatales (CPP) y su situación actual en los servicios de ginecoobstetricia y neonatología en el mundo y sus posibles beneficios. Metodología: Se realizó un estudio de revisión bibliográfica, sobre la evidencia científica actual de los programas de CPP alrededor del mundo, publicados desde el 2008 a 2018. Se utilizaron las bases de datos Medline, PubMed, Google Scholar y EBSCO, con descriptores como “perinatal palliative care” OR “prenatal palliative care” AND “perinatal grief”; se incluyeron guías y protocolos de prácticas clínicas publicados por diferentes entidades de salud, así como estudios revisiones sistemáticas y estudios tanto epidemológicos como intervencionales. Resultados: La atención temprana de las familias que llevan embarazos en donde el o la bebé posee una patología con condiciones de vida limitantes, dentro del marco de un programa de CPP, facilita el vínculo afectivo, la despedida y el duelo. La falta de información y sensibilización en profesionales de salud para atender a estas familias, así como la carencia de espacios, guías y protocolos definidos crean en las familias un ambiente de inseguridad y desesperanza. Costa Rica al igual que la mayoría de los demás países de América Latina, no cuenta con programas específicos de CPP, ni criterios de calidad para conformarlos o evaluarlos. Conclusión: Se logra constatar la necesidad en el ámbito nacional de protocolos o guías de trabajo en el área de CPP, también de realizar más investigaciones, esto con la finalidad, de establecer mayor preparación de los profesionales afines a la atención de las familias que enfrentan estas situaciones y así otorgar un entorno más favorable para ellos.
Cátedra integradora una opción para incrementar los niveles de retención y titulación en las instituciones educativas.
Authors: Narváez Peña Maria Fernanda
Published: August 2019

Es significativo establecer mediante revisión bibliográfica la importancia de la catedra integradora para ayudar a elevar la tasa de retención y titulación de las universidades.

La catedra integradora se constituye en una herramienta para ayudar a los jóvenes universitarios a conocer de cerca cómo va a ser su futuro profesional, porque de forma obligatoria deberán desarrollar diferentes proyectos que los ayudara a vincularse con la sociedad.

La falta de material informativo para el desarrollo de esta asignatura y el desconocimiento de muchos profesionales en el tema ha motivado que el presente artículo tenga como objetivo establecer mediante revisión bibliográfica los principales conceptos, teorías y la importancia de la catedra integradora en el modelo pedagógico de las instituciones educativas, pero sobre todo como desarrollarla acorde al nivel de estudios que este cursando el estudiante.

Uno de los objetivos de esta asignatura es el de integrar los conocimientos de todas las materias en una sola para que no queden como agentes aislados y así el estudiante logre un conocimiento integrador.

 

El trabajo en equipo es fundamental para lograr cumplir con los objetivos planteados en la asignatura no solo el trabajo en equipo de los estudiantes sino de todos los docentes y del directivo porque el fin es integrar los conocimientos adquiridos en las aulas.

Finalmente en este articulo el lector podrá visualizar como desarrollar la catedra integradora acorde al nivel en donde se encuentre la asignatura acorde a cada malla de estudios, como conclusión principal se puede destacar que  la catedra integradora permite el crecimiento de los conocimientos adquiridos por parte de docentes y estudiantes a través de proyectos educativos que permite la  vinculación del estudiante con la sociedad y así acercar al máximo a   los jóvenes universitarios  a las funciones que van a desarrollar una vez que terminen su carrera.
PENGARUH CLAPPING, VIBRASI DAN SUCTION TERHADAP TIDAL VOLUME PADA PASIEN PNEUMONIA YANG MENGGUNAKAN VENTILATOR DI RUANG ICU ROYAL PRIMA MEDAN
Authors: Vaulina Agnesia , Malinda Yana , Gulo Yunistia , Oktavianus Victory , Nababan Tiarnida
Published: August 2019

See the impact that can occur in patients who use ventilators and the ability of patients to issue very limited secretions, it is very necessary to help the patient in maintaining the hygiene of the road, so that the breathing runs smoothly. One of the efforts that can be done is clapping, vibration and suction in accordance with the operational standards of Prosdur. The purpose of this research is to identify the influence of clapping, vibration and suction against tidal volumes in pneumonia patients who use a ventilator in the ICU room of Royal Prima Medan Hospital. The design of this research uses the experimental quasi method. Samples on this study were as much as 10 people based on the total population during 2 weeks from 1st to 15th July 2019 with total sampling technique. The instrument used is an observation sheet in a ventilator-using pneumonia patient. The test used in this study is the T-Dependen test to see the influence of clapping, vibration and suction against tidal volumes with significant value (P < 0.05). The advice of this research is to be expected to the hospital, especially health workers pay attention to the hygiene of the airway by doing the action of claping, vibration and suction especially in patients who are diagnosed with pneumonia are treated with ventilators.
The Future of International Statistical Data Sharing and New Issues of Interaction
Authors: Bashina O. E. , Komkova N. A. , Matraeva L. V. , Kosolapova V. E.
Published: August 2019

The article deals with challenges and prospects of implementation of the Statistical Data and Metadata eXchange (SDMX) standard and using it in the international sharing of statistical data and metadata. The authors identified potential areas where this standard can be used, described a mechanism for data and metadata sharing according to SDMX standard. Major issues classified into three groups - general, statistical, information technology - were outlined by applying both domestic and foreign experience of implementation of the standard. These issues may arise at the national level (if the standard is implemented domestically), at the international level (when the standard is applied by international organizations), and at the national-international level (if the information is exchanged between national statistical data providers and international organizations). General issues arise at the regulatory level and are associated with establishing boundaries of responsibility of counterpart organizations at all three levels of interaction, as well as in terms of increasing the capacity to apply the SDMX standard. Issues of statistical nature are most often encountered due to the sharing of large amounts of data and metadata related to various thematic areas of statistics; there should be a unified structure of data and metadata generation and transmission. With the development of information sharing, arise challenges and issues associated with continuous monitoring and expanding SDMX code lists. At the same time, there is a lack of a universal data structure at the international level and, as a result, it is difficult to understand and apply at the national level the existing data structures developed by international organizations. Challenges of information technology are related to creating an IT infrastructure for data and metadata sharing using the SDMX standard. The IT infrastructure (depending on the participant status) includes the following elements: tools for the receiving organizations, tools for sending organization and the infrastructure for the IT professionals. For each of the outlined issues, the authors formulated some practical recommendations based on the complexity principle as applied to the implementation of the international SDMX standard for the exchange of data and metadata.
Esclarecimento da população de Dourados-MS sobre maus-tratos em cães e gatos
Authors: De Oliveira Mariana Sakai , Maciel Larissa Machinski , Sunada Natália da Silva
Published: August 2019

A população de animais de estimação vem aumentando paralelamente ao crescimento populacional humano, assumindo proporções quase igualitárias, sendo muitas das vezes negligenciadas as necessidades básicas para a sobrevivência destes. Sendo assim, o objetivo deste trabalho foi de avaliar o grau de esclarecimento da população de Dourados-MS sobre a posse responsável de seus animais de estimação. Para tanto, foi aplicado questionário contendo questões relacionadas à temática de maus-tratos aplicados aos animais, cujo preenchimento ocorreu de maneira manual ou eletrônica por 653 entrevistados escolhidos aleatoriamente. Verificou-se que ainda há uma falta de esclarecimento sobre a posse responsável de animais independentemente da posição social, já que grande parte das entrevistas realizadas consistiu de indivíduos que possuem algum grau de instrução (99,8%), renda familiar (95,2%) e idade superior a 20 anos (84,3%). Constatou-se que 39,8% dos entrevistados alegou não realizar passeios com seu animal de estimação; 5,5% admitiram nunca ter realizado uma consulta veterinária; 3,7% não realiza os procedimentos para limpeza normal de seus animais; 1,10% aprisionam por todo o período do dia através de correntes seus animais e 3,9% dos guardiões aplicam agressão física aos seus animais quando algo os desagrada. Desta maneira, conclui-se que existe a necessidade de um número maior de campanhas com formas mais esclarecedoras das modalidades de maus-tratos sofridos pelos animais.
Qualitative Analysis of Test Strip for Sildenafil Citrate with Some Combinations Reagen in Cellulosa Paper Membran
Authors: Sutrisno Yessy Gladiani , Khoirunnisa Siska , Agustien Diani Sri , Karyati Eva , Fasya Nabila , Wasito Hendri
Published: August 2019

Sildenafi l citrate was widely used to treat erectile dysfunction in men. The high demand of this drug, infl uence of counterfeit drugs. Therefore, it is required an analytical method to determine the authenticity of this drug. The aims of this research were to develop and evaluate of strip test for sildenafi l sitrat identifi cation. Research was conducted by preparation of solution and choosing the appropriate reagent for sildenafi l citrate. The optimum reagents were immobilized in cellulose paper followed by manufactured into strip test. Product performance was evaluated by evaluating several test in termed of qualitative, reproducibility, specifi city and response time. The results showed that the optimum membrane product was consisted of copper sulfate and sodium bicarbonate (2:1); ammonium ferric sulfate hexahydrate and copper acetat (1:3); sodium sulfate, copper acetate and ammonium ferrite sulfate (2:1:1) and mercury acetate and copper sulfate (2:1) reagents. The strip test had a capability in specifi c identify of sildenafi l citrate with a good reproducibility and less than ten seconds for time response. The strip test developed could be used as an early detection tool for the authenticity of a sildenafi l citrate tablet which more rapid.
Effect of Pleurotus Ostreatus on Pancreatic Beta Cells of Diabetes Mellitus Mice Model
Authors: Wahyuni Ningrum , Ilyas Syafrudin , Fitrie Alya Amila
Published: August 2019

Over the last 30 years, the number of people suffering from diabetes mellitus has doubled globally. Adipose tissue dysfunction plays an important role in insulin resistance. Mushroom has been traditionally used to prevent diabetes. This research aims to study the anti-oxidative effect of Pleurotus ostreatus on pancreatic beta cells. This study is an experimental posttest only control group design. The subjects were 24 male wistar mice, divided into six groups. Group P0 was given distilled water and citrate buffer. Group P1 was given high fat diet (HFD) and low dose streptozotocin (STZ). Group P2 and 3 were given HFD and low dose STZ along with Pleurotus ostreatus ethanol extract. Group P4 and P5 were given HFD and low dose STZ, and then given Pleurotus ostreatus ethanol extract. Blood glucose levels and pancreatic beta cells area count were done after treatment. Data obtained was analyzed using one-way ANOVA test. One-way ANOVA test showed signifi cant difference in all the groups (p<0.05). Post Hoc test results showed difference in blood glucose levels and pancreatic beta cells area count. Pleurotus ostreatus ethanol extract can prevent cellular damage to murine pancreatic beta cells but unable to reverse the damage to the beta cells.
Comparison of Efficacy and Side Effect Between Albendazole, Albendazole-Levamisole and Mebendazole-Levamisole Againts Soil-Transmitted Helminths Infection at a Public Elementary School-Age Children on The Deli Serdang Regency
Authors: Julianto Endy
Published: August 2019

Intestinal worm infection in particular of Soil Transmitted Helminth is still a global problem with high prevalence on the tropic and subtropic regions including Indonesia especially in the rural community. Double Blind Randomized Trial that started from April to June 2015 in which the samples are collected from public elementary school children on the Deli Serdang Regency to compare the effectivity and side effect of STH infection treatment by using Albendazole 400 mg, Albendazole 400 mg-Levamisol 50 mg/100 mg, Mebendazole 500 mg-Levamisol 50 mg/100 mg. The samples of Albendazole, Albendazole-Levamisol and Mebendazole-Levamisol groups consist of 60 children in each group in which the ones that have STH infection are Ascariasis 92 children 51.11%, Trichuriasis 37 children 20.55%, and mixed infection 51 children 28.33%. In this research, researcher doesn’t found hookworm infection in any of the groups. From the result ofstool examination, researcher found 100% of cure rate for A. lumbricoides infection on all groups, cure rate of T. trichiura infection 66.7%, 94.7%, 92.3% for each Albendazole, Albendazole-Levamisol, and Mebendazole-Levamisol groups meanwhile cure rate for mixed infection are 28.6%, 85.7%, and 66.7% for each Albendazole, Albendazole-Levamisoland Mebendazole- Levamisol groups. For mild T.trichiura infection treatment with singledose of Albendazole-Levamisolgroup is better than both of Albendazole and Mebendazole- Levamisole groups (p=0.01). In this research, researcher found nausea and diarrhea as treatment of side effect and no signifi cant difference of side effect in all groups of treatment.
Antibacterial Activity of Ethyl Acetate Culture Broth Extract from Endophytic Fungi of Nigrospora oryzae Associated with Rhizophora mucronata
Authors: Fareza Muhamad S. , Ayoesty Lingling T. , Wargiyanti Siti R.
Published: August 2019

The purpose of this study was to provide information on the antibacterial activity of ethyl acetate culture broth extract of endophytic fungi associated with Rhizophora mucronata. An isolated fungi was identifi ed as Nigrospora oryzae using microscopic and molecular analysis. Theantibacterial activity was carried out using micro dilution method to get MIC value. The ethyl acetate extract showed antibacterial activity with MIC value of 250 μg/mL against and Escherichia coli and 500 μg/mL against Staphylococcus aureus.
Determination of Quality Parameters and Antioxidant Activity of Cincau Hijau Leaves (Cyclea barbata L.Miers.)
Authors: Gangga Erlindha , Purwati Rani , Farida Yunahara , Kartiningsih Kartiningsih
Published: August 2019

Cincau Hijau leaves (Cyclea barbata L.Miers ) has been used empirically as a medicinal plant because it contains many potential compounds such as flavonoids. Cincau Hijau leaves has been known as antioxidant activity. Determination of pharmacognosy parameters and phytochemical screening of dry leaves and extracts have been carried out as well as determination of total fl avonoids content. Fresh leaves were extracts with water and Dry leaves were macerated with 96% ethanol and were then concentrated by rotavapor to obtain viscous extracts. Free radical scavenging activity of the extracts was evaluated using DPPH method. Afterwards, determination of specifi c and non-specifi c parameters were performed. Results of phytochemical screening of powder and 50% and 96% ethanol extract showed that tall the tested samples contained alkaloid, fl avonoids, saponins, tannins, steroids/ triterpenoids, coumarin. The examination of specifi c parameter showed that the extract has a thick consistency, tawny color, bitter taste, characteristic odor. In addition, water-soluble compound and 96% ethanol extract are 46.64 and 62.13% respectively whereas ethanol-soluble compounds are 39.22 and 74.72%, respectively. While the results of nonspecifi c parameters of 50% and 96 % ethanol extract displayed total ash content of 9.69 and 9.49%, respectively, acid insoluble ash content of 0.30 and 0.16%, respectively, content of water soluble ash of 9.17 and 4.30%, respectively, loss on drying of 9.35 and 8.9%, respectively, water content of 8.45 and 7.25%, respectively. Based on heavy metal contamination, Pb concentration in 50 and 96% ethanol extract are 0.0227 and 0.0333 mg/kg, respectively whereas Cd concentration are 0.1206 and 0.0022 mg/kg, respectively and total number of CFU of 4,22 x 103 and 2,30 x 103 colonies/g, respectively while molds and yeasts number of colony of 0,48 x 102 and 8,88 x 102 colonies/g, respectively. Moreover, the total flavonoid was 0,19 %. Result of DPPH inhibition test showed that IC50 96 % ethanol extract are 83,280 ppm and water extracts are 102,01 ppm
Effect of Gold Sea Cucumber (Stichopus hermanni) Extract Concentration on Antioxidant Activity of Grape Seed Oil (Vitis vinifera) nanoemulsion
Authors: Noor Siti Umroh , Gozali Amelia
Published: August 2019

Gold sea cucumber extract (Stichopus hermanni) is rich in collagen and unsatturated fatty acid also known omega 3 such as docosahexaenoic acid and eicosapentaenoic acid that highly effective as an antioxidant. Oligomeric proanthocyanidin is the main content in grape seed oil and the most powerful antioxidant agent that can protect collagen. The aim of research was to determine the effect of gold sea cucumber extract concetration on antioxidant activity of grape seed oil nanoemulsion. The three formulas with results test of antioxidant activity with DPPH method using 15% Brij CS12® and 30% propylene glycol has done which the oil phase was dispersed in the aqueous phase.Variation that have been done is to use the antioxidant activity (IC50) of gold sea cucumber extract  for 2, 4, and 6 times. The resulting preparations was conformed of organoleptic, nanoemulsion type, clarity, globule size, viscosity and rheology, pH and freez thaw test. Antioxidant activity of gold sea cucumber extract and grape seed oil were  (IC50= 53.79 and 17.41 μg/mL respectively). The nanoemulsion was analysed using two-way ANOVA method. Antioxidant  activity at storage for 0; 2 and 4-weeks of formula I, II, III were (IC50=  49.15; 49.45, 51.15 µg/mL), (IC50= 44.12, 47.48, 48.14 µg/mL), and (IC50= 42.14, 43.45, 45.33 µg/mL) respectively. Can be concluded that the higher concentration of gold sea cucumber extract, the antioxidant activity of nanoemulsion is higher, but it decreased during the storage.
Factors Affecting The Drugs Availability on Program Rujuk Balik (PRB) at PRB Drugs Facility in Ex Karesidenan Kediri (Study of Hipertension Drugs)
Authors: Tuti Sri Dias , Athiyah Umi , Utami Wahyu
Published: August 2019

PRB drugs service was given to chronically patients who still need long term treatment therefore there was need to guarantee the availability of medicines for their therapeutic needs. The objectives of this research were to know about PRB drug management, to know drug management support, policy, the availability of PRB drugs, and to analize the effects of drug management, drug management support, and policy on drug availability in PRB drug facility in Ex Karesidenan Kediri. Study on the availability of drugs hypertension due to prevalence of hypertension  disease tends to increase from 7.6% in 2007 to 9.5% in 2013. This research used cross sectional approach by giving questionnaires to 18 respondents of PRB drug managers who had fulfilled the inclusion criteria. Those respondents were measured on the capability in PRB drug managements and assessment of PRB drug management support and policy. The questionnaires were valid and reliable. The management, management support, and policy score were tested for effect on PRB drug availability for Hypertension by using multiple linear regression. From this research, it was known that PRB Drug Management, PRB Drug Management Supporting Assessment, and PRB Policy by PRB drug managers in drug service facilities in Ex Karesidenan Kediri were mostly categorized as good enough.  The availability of PRB drugs at PRB drugs facility with stock calculations indicated the ability to provide PRB medication to serve PRB prescription of hypertension was 28.71%. While the facilitieas that were able to serve an average of 72.67, thus providing substitution drugs beyond the average of PRB stock of 43.95%. The efforts were done for examples, borrowed similar drugs from regular supplies, medicines administered when they were available, or established the similar drugs at prices closed to e-catalogue. The results of the analysis showed that simultaneously PRB Drug Management factors, PRB Drug Management Supports, and PRB Policy have significant effects on PRB Drug Availability (p<0.10). PRB drug management had the greatest effects on the availability (p<0.10), especially in the case of Drug Selection (p<0.10). Selection of drugs was the first step to be done from a cycle of drug management, where the early step was the step that most determine the next steps. The pharmaceutical management framework affected the availability of PRB drugs, particularly the Drug Management factor, especially in the drug selection step. Drug selection was an early step of the drug management cycle that determined the next step.
Creambath FORMULATION WITH CONCENTRATION VARIATION WATER EXTRACTS OF AMBON Banana Weevil (Musa acuminata Colla)
Authors: Indrawati Teti , Sofia Nabhilla
Published: August 2019

Ambon banana (Musa acuminata Colla) humps contain anthraquinone compounds that effectives This research aims to take advantage of the hump to be confectionary cream bath as hair growth.  Water extracts of Ambon banana humps were blended and filtered, and then, this water extracts of Ambon banana was made into cream bath using concentration of 8%, 10%, and 12%. The method that is used to make cream bath is dissolution and mixing methods at a temperature of 75oC–80oC and the water extract was add at 40oC. These cream bath products weres evaluated by organoleptic, homogeneity, emulsion type, pH, spreading ability, viscosity and flow character. All formula cream bath preparations had white to ivory white, odourless bananas, emulsion type o/w, homogenized, pH 6.05 to 6.38, spreading ability 4862.05 mm2-3672.67 mm2, has a viscosity of 12000 cps-145000 cps, and showed the flow properties pseudo-plastic thixotropic.