bluuebunny/crossref_metadata_2025 huggingface dataset:
Di-n-butyl phthalate regulates insulin sensitivity in human skeletal muscle cell line through the PI3K-AKT-GLUT4 signaling pathway
Authors: Wen Ao , Shan Dan , Chen Yan , Zhang Jing , Zhou Kunyan
Published: March 2023

Background
Dibutyl phthalate (DBP) exposure is a serious environmental problem causing human health threats in China and is closely related to the development of insulin resistance, but its mechanism is unclear. Skeletal muscle tissue is one of the important tissues involved in insulin resistance, and its molecular mechanisms may involve various links of the insulin signaling cascade in muscle cells.
Methods
In this study, the mRNA and protein expression of the above signaling gene were detected and quantified by Real-time quantitative PCR (RT-qPCR) and Western blotting in human skeletal muscle cell line HSkMC cells, and the InsR-IRS1-PI3K-AKT-GLUT4 signaling pathway as the entry point.
Results
The mRNA levels of InsR, IRS-1, PI3K, AKT2, and GLUT4 were reduced after DBP treatment compared with control cells.DBP and PI3K inhibitor BKMl20 or DBP transfected with PTEN overexpression lentivirus further reduced the mRNA expression levels of PI3K, AKT2, and GLUT4. In addition, DBP treatment also reduced the expression of InsR, IRS-1, PI3K, AKT2, and GLUT4 and the phosphorylation of AKT2, but both DBP with BKMl20 or DBP was transfected with PTEN overexpression.
Conclusions
Based on the above results, this study is the first to find a possible molecular mechanism of DBP in skeletal muscle insulin resistance through regulating the PI3K-dependent insulin signaling pathway of skeletal muscle cells, providing a rationale for the pathophysiological changes in the initiation and progression of insulin resistance caused by DBP.
Modulation of memory consolidation by heroin and heroin conditioned stimuli: roles of expectation and dopamine D1 receptor?
Authors: Francis Travis , Leri Francesco
Published: March 2023

It has been theorized that drugs of abuse have enhancing effects on memory consolidation, but recent evidence suggests that this cognitive effect may be mediated by mode of drug administration (i.e., passive vs active). Hence, two studies were designed to test the hypothesis that modulation of memory consolidation by heroin, and by a heroin conditioned stimulus (CS), may be mediated by a dopamine D1 receptor dependent mechanism of prediction error. Using male Sprague-Dawley rats and the object location memory task, Study 1 employed the D1 antagonist SCH23390 (0, 0.05, 0.10 mg/kg, subcutaneous, SC) to modulate enhancement of memory consolidation induced by post-training passive injections of heroin (1 mg/kg, SC) as well as by exposure to the environment paired with heroin injections (6 pairings, 1 h each, 1 mg/kg). Study 2 investigated the same hypothesis but in animals that could learn to predict heroin because the drug was self-administered (0.05 mg/kg/infusion, intravenous), and further explored whether SCH23390 (0 and 0.1 mg/kg) could prevent memory modulation induced by a change in schedule of self-administration (from fixed to variable ratio). It was found that while repeated passive injections of heroin retained their modulatory effect on memory, when self-administered, heroin enhanced consolidation of object location only at the beginning of self-administration and after a change in schedule. Importantly, SCH23390 blocked memory modulation by heroin when passively administered and when the drug was self-administered on a novel schedule. SCH23390 also blocked conditioned memory modulation induced by post-training exposure to the heroin-paired CS. Taken together, these results suggest that modulation of memory consolidation by unconditioned and conditioned opiate reinforcers may involve a DA D1-dependent mechanism that could be encoding the anticipation of drug effects.
Potential functions for functionally graded transversely isotropic media subjected to thermal source in thermoelastodynamics problems
Authors: Panahi Siavash , Neya Bahram Navayi
Published: March 2023

This paper develops a novel set of displacement temperature potential functions to solve the thermoelastodynamic problems in functionally graded transversely isotropic media subjected to the thermal source. For this purpose, three-dimensional heat and wave equations have been considered to obtain the displacement temperature equations of motion in the case of functionally graded materials. A systematic method is used in the present work to decouple the elasticity and heat equations. For governing equations, one sixth order differential equation and two second order differential equations are obtained. Completeness proof of the solution is also presented using a retarded logarithmic Newtonian potential function for the functionally graded transversely isotropic domain. To verify the obtained solution, in a simpler case, potential functions have been generated for homogeneous transversely isotropic media that coincide with the respective equations. Presented potential functions can be used to solve the problems in various media like infinite and semi-infinite space, beams and columns, plates, shells, and etc. with arbitrary boundary conditions and subjected to arbitrary mechanical and thermal loads.
Energy, exergy, economic and environmental analysis of a regasification system integrating simple ORC and LNG open power cycle in floating storage regasification units
Authors: Naveiro Manuel
Published: March 2023

A thermodynamic, economic and environmental analysis of a regasification system including a simple Organic Rankine Cycle (ORC) and an Open Organic Rankine Cycle (OC) to utilise the liquefied natural gas (LNG) cold energy is carried out in the present paper. The proposed system, called ORC-OC, uses ambient seawater as heat source (open loop) and is implemented on board a Floating Storage Regasification Unit (FSRU) in order to reduce the greenhouse gas (GHG) emissions associated with the electricity generation plant, i.e., dual fuel (DF) engines. Regarding the ORC working fluids analysed, an ethane/propane zeotropic mixture is applied. The ORC-OC is compared with the simple ORC architecture, giving the first one better energy (lower specific energy consumption), exergy (higher exergy efficiency) and environmental (lower CO2e emissions) results. When compared to the regasification systems installed on board, the ORC-OC system reduces the specific energy consumption by 86.99 % and increases the exergy efficiency by 17.82 % with respect to the most efficient conventional system installed on FSRUs (direct seawater regasification system), leading to a reduction of CO2e emissions of more than 80 %. In addition, the ORC-OC system is more cost-effective than conventional regasification systems when the LNG price is above 6,508 USD/MMBtu.
Open repurchase announcements and abnormal returns of Indian firms: An industry-wise analysis
Authors: Bhama Vandana
Published: March 2023

Although the tender offer buyback method has gained significance over time, many companies still prefer open market repurchases. The existing literature focuses mainly on the impact of buyback announcements, specifically on stock returns; however, buyback announcements and abnormal returns in the case of open market repurchases have not yet been studied in detail, especially across industries in the Indian context. This study, therefore, attempts to analyze the impact of open market repurchase announcements on the stock returns of Indian firms. To that end, the event study methodology has been used for a period of 31 days, i.e. 15 days prior to and 15 days after the buyback announcement on a filtered sample of 100 firms during the period 2010–2020. The results of the study indicate that the returns were more favorable in the short run. The findings do not support the undervaluation rationale of firms behind the open buyback statement. The low-profit opportunities in the prior event window convey investors’ predictions about the repurchase announcement. In the context of industries, the manufacturing sector seemed to be far better than IT & telecom, chemical, and pharma firms as the returns were statistically significant for five (5) out of 31 days. The industry-specific results also suggest that the profit opportunities are majorly in the pre-announcement phase. The overall findings corroborate that share repurchases might be irrelevant to shareholders’ wealth. Therefore, open market buybacks may support decisions related to capital structure changes.
AcknowledgmentThe infrastructural support provided by the FORE School of Management, New Delhi in completing this paper is gratefully acknowledged.
A comparative evaluation of the efficacy and safety of Latanoprost-Optic and Xalatan used as monotherapy and combined with Dorzolamide-Optic for primary open-angle glaucoma under clinical practice conditions
Authors: Novikov D. P. , Frolov O. A. , Pokrovsky A. S. , Novikova V. V.
Published: March 2023

The number of ophthalmic antihypertensive drugs available in Russia is steadily increasing, which complicates the choice to be made by ophthalmologist practitioners. Purpose: to compare the efficacy and safety of the domestically produced drug Latanoprost-Optic with the original drug Xalatan used as monotherapy or combined with the domestic drug Dorzolamide-Optic in patients with primary open-angle glaucoma (POAG). Material and methods. 116 completed cases of patients aged 69.3 ± 5.7 with newly diagnosed POAG were retrospectively analyzed, whereby we assessed the efficacy, safety and tolerability of monotherapy with Latanoprost-Optic or Xalatan and their combinations with Dorzolamide-Optic. Results. Latanoprost-Optic efficacy is no worse than that of Xalatan as it reduces intraocular pressure (IOP) by 33.8%, and has a comparable safety and tolerability profile. More than 72% of patients rate the tolerability of treatment with LatanoprostOptic as very good or good. An additional hypotensive effect of Dorzolamide-Optic added to latanoprost is 2.6–2.8 mm Hg, or 13.2–14.4% and involves no significant effect on the safety profile and tolerability of therapy. Conclusion. Latanoprost-Optic can be considered as a more affordable alternative to the original drug. If the target IOP values cannot be achieved by latanoprost alone, its combination with DorzolamideOptic is recommended, especially for patients with chronic diseases of the respiratory system and the cardiovascular system.
Endothelin-1 level in the tear fluid of children with primary congenital glaucoma
Authors: Katargina L. A. , Сhesnokova N. B. , Arestova N. N. , Sorokin A. A. , Pavlenko T. A. , Beznos O. V. , Lisovskaja O. A.
Published: March 2023

Purpose. To analyze the level of endothelin-1 (ET-1) in the tear fluid (TF) of children with primary congenital glaucoma (PCG) and to detect possible correlations between the clinical and the laboratory data. Material and methods. We examined 23 eyes of 15 children with PCG aged between 7 months and 15 years and 3 healthy fellow eyes of these children. 25 eyes of children of same age without glaucoma (somatically healthy with mild hyperopia and/or concomitant strabismus) served as control. A standard ophthalmological examination was supplemented by the flash visual evoked cortical potential, a total and a rhythmic electroretinogram, axial length (AL) echobiometry of the eye, optical coherence tomography of the optic nerve head, enzyme immunoassay (ELISA) of ET-1 level in TF were given. Results. In most children with PCG (95.6 %), the TF level of ET-1 (mean 9.69 ± 3.80 pg/ml) was higher than that in healthy children (4.65 ± 2,02 pg/ml) (p < 0.001). Increased levels of ET-1 (up to 8.90 pg/ml) were also detected in healthy fellow eyes of children with PCG. The mean level of ET-1 in children with PCG aged 3 to 15 years was significantly higher (p< 0.05) lower than in the initial stage. Our study revealed no correlations between the ET-1 level and the degree of retinal nerve fiber layer thinning, or the AL in children with PCG. Conclusion. For the first time, an increased level of ET-1 in the TF in children with PCG was revealed as compared to healthy children. A lower value of ET-1 in the far advanced PCG stage as compared to the initial stage can be explained by long-term chronic eye tissue hypoxia depleting the protective reserves of the eye. Since no obvious correlation between ET-1 level in the TF and clinical and functional data of children with PVG has been found, we cannot definitely view the ET-1 level in the TF as a measure of ischemia degree in PCG. Further studies are needed to obtain reliable correlations.
Hypotensive therapy effectiveness evaluation in primary open-angle glaucoma evidenced by pattern electroretinogram data
Authors: Tur E. V. , Kozhevnikova T. Yu.
Published: March 2023

Purpose. To evaluate the change in the functional activity of retinal ganglion cells (RGCs) in response to intraocular pressure (IOP) drop in patients with newly diagnosed early stage primary open-angle glaucoma (POAG) using a pattern electroretinogram (PERG). Material and methods. A prospective non-randomized cohort study included 12 patients (24 eyes) including 5 men, 7 women, aged 63.42 ± 2.96 years with newly diagnosed early stage POAG in at least one eye, who underwent PERG (Diopsys Nova, Diopsys, Inc.) in addition to an ophthalmologic examination. After being diagnosed with POAG, all patients were prescribed prostaglandin analogues as monotherapy. One and four months into the treatment, repeated examinations took place. Results. At these time points, a significant decrease in IOP was noted, accompanied by an increase in PERG parameters , which indicates an improvement in the functional activity of RGCs, yet no linear relationship between the IOP decrease and the improvement in PERG parameters could be found. Conclusion. Early stage naïve-treatment POAG patients with minimally impaired visual fields as determined by threshold computer perimetry may have their RGCs functional activity partially restored and IOP lessened thanks to continuous IOP-lowering therapy with prostaglandin analogues. PERG can be used as a method for evaluating the effectiveness of glaucoma hypotensive therapy in terms of maintaining and improving the functional activity of RGCs.
Robots sociales y crecimiento ético en Educación Infantil
Authors: Gómez-León María Isabel
Published: March 2023

Durante los últimos años ha incrementado el desarrollo de robots sociales educativos. Estos robots favorecen vínculos afectivos positivos y aumentan el bienestar socioemocional de los estudiantes, sin embargo, tanto los niños como los adultos han demostrado potencial para tratar a los robots sociales de manera abusiva. Para lograr interacciones robot-humano favorables y mejorar las interacciones humanas surge la necesidad de crear comportamientos robóticos cada vez más empáticos al tiempo que se garanticen las condiciones óptimas de una educación orientada al crecimiento ético de los estudiantes. El objetivo de esta revisión es analizar qué componentes del diseño robótico facilitan o debilitan las interacciones socioemocionales entre los niños de edad preescolar y los robots antropomórficos. Se realizó una búsqueda exhaustiva en las bases de datos Scopus, Web of Science, PubMed, IEEE Xplore y ACM Digital Library siguiendo los criterios establecidos en la declaración PRISMA. Los resultados sugieren que la apariencia de un robot destinado para niños en edad preescolar necesitaría equilibrar la "humanidad" y la "robotidad" para que ambos estimulen interacciones sociales placenteras y prevengan falsas creencias sobre las capacidades del robot, lo que probablemente disuadiría al niño de participar en conductas abusivas que podrían ser perjudiciales en otros contextos.
La privacidad de los datos en Tecnología Educativa: resultados de una revisión de alcance
Authors: Marín Juarros Victoria , Tur Ferrer Gemma
Published: March 2023

La privacidad de los datos en el uso de la tecnología en educación es un aspecto ético de interés creciente. El fenómeno conocido como datificación se ha visto aventajado con el uso de sistemas de analíticas de aprendizaje y de inteligencia artificial, que permiten la recogida y el análisis de grandes cantidades de datos. Si bien es un aspecto que preocupa, cuenta todavía con poca investigación. El objetivo de este estudio es analizar la literatura que trata este aspecto ético desde sus características básicas hasta los temas principales abordados, con la intención de poder identificar vacíos en la literatura y líneas de trabajo ya desarrolladas. A través de una revisión de literatura de alcance previa sobre aspectos éticos en tecnología educativa con 99 estudios, se identificaron 42 publicaciones que se centraban en el tema de la privacidad de los datos. La mayoría de trabajos son de carácter teórico y se centran en los estudiantes de educación superior. Algunos trabajos proponen recomendaciones sin concretar estrategias de trabajo, lo que contribuye a la consideración más bien superficial de la temática. Como líneas futuras se propone orientarse a estas estrategias de trabajo, considerando además, todos los niveles educativos.
Tecnologías digitales en educación: poniendo el foco en la ética
Authors: Carrera Farran Xavier , Pérez Garcias Adolfina
Published: March 2023

En el texto se expone de forma sintética el estado actual de la investigación centrada en aspectos de ética digital aplicada en educación. También se enfatiza la necesidad de plantear estudios que aborden, desde una perspectiva ética, las problemáticas asociadas a la incorporación de la inteligencia artificial en educación. Se presentan los artículos que se publican en el número especial "Tecnologías digitales en educación: poniendo el foco en la ética".
Molecular Modeling Studies of β-Sitosterol Extract from Miconia burchellii Triana (Melastomataceae) from Brazilian Cerrado
Authors: Silva Marianna , Duarte Vitor , Sallum Lóide , Cunha Gracielle , Custodio Jean , Oliver Allen , Peixoto Josana , Menezes Antônio , Napolitano Hamilton
Published: March 2023

The Brazilian Cerrado biome is considered one of the 25 hotspots worldwide that contain bioactive compounds due to its great biodiversity; however, the reduction of its native area over time due to the expansion of urbanization and agribusiness may have compromised knowledge of its biological variety. In this context, knowledge about Cerrado species can contribute to its biodiversity preservation. This study aims to describe the isolation, molecular architecture and theoretical calculations of the compound (3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5R)-5-ethyl -6-methylheptan-2-yl]-10,13 dimethyl 2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro1H-cyclopenta[a]phenanthren-3-ol, extracted from the Brazilian Cerrado Miconia burchellii plant. The supramolecular arrangement was described by Hirshfeld surface analysis, demonstrating the intermolecular interactions in the crystalline packing. The structure-property relationship shows the electrostatic potential map analysis, which reveals that the oxygen region is susceptible to electrophilic attack, and the frontier molecular orbital confirmed the kinetic stability of this compound. This study represents another step forward in the knowledge of compounds with pharmacological and medicinal properties extracted from the Cerrado.
Mechanical characterization of bottom hole assembly in air drilling engineering
Authors: Han Yutian , Tang Bin , Zhang Tao , Liu Jinlong , Wang Yanming , Yang Li , Yang Kang
Published: March 2023

To study the mechanism and control of well deviation in air drilling, a mechanical model of bottom hole assembly (BHA) with double stabilizer is established by using the beam-column method. The mathematical model related to side force of BHA and deviating force of strata are derived by analyzing the characteristics of gravel strata in the practical engineering. The effects of weight on bit (WOB), expansion ratio of borehole diameter (ERBD), angle of well inclination, diameter of drill collar and strata bending moment on side force of BHA are explored. Then, the superposition of bit side force and deviating force of strata is obtained. The results display that side force of BHA is obviously influenced by ERBD, angle of well inclination, diameter of drill collar and strata bending moment; and the deviation force and azimuth force of gravel strata are significantly affected by comprehensive cutting anisotropy index, angle of well inclination and dip angle of strata. Finally, the variation tendency of inclination angle and azimuth angle in field measurement is consistent with the theoretical and numerical researches. The present work can provide theoretical guidance to control the well deviation in the practical air drilling.
Dampak Pengembangan Kemasan terhadap Minat Beli
Authors:   Universitas Prasetiya Mulya Kavling Edutown I. 1 Jl. BSD Raya Utama, BSD City, Tangerang, Indonesia, Adrian N. Nikolaus Elvan , Agung Angelia ,   Universitas Prasetiya Mulya Kavling Edutown I. 1 Jl. BSD Raya Utama, BSD City, Tangerang, Indonesia, Lison Enrico ,   Universitas Prasetiya Mulya Kavling Edutown I. 1 Jl. BSD Raya Utama, BSD City, Tangerang, Indonesia, Lokita Ivana ,   Universitas Prasetiya Mulya Kavling Edutown I. 1 Jl. BSD Raya Utama, BSD City, Tangerang, Indonesia, Ethan Prawira Matthew ,   Universitas Prasetiya Mulya Kavling Edutown I. 1 Jl. BSD Raya Utama, BSD City, Tangerang, Indonesia, Luis Richardo ,   Universitas Prasetiya Mulya Kavling Edutown I. 1 Jl. BSD Raya Utama, BSD City, Tangerang, Indonesia, Marsha Qinthara ,   Universitas Prasetiya Mulya Kavling Edutown I. 1 Jl. BSD Raya Utama, BSD City, Tangerang, Indonesia, Chandra M. Nany ,   Universitas Prasetiya Mulya Kavling Edutown I. 1 Jl. BSD Raya Utama, BSD City, Tangerang, Indonesia
Published: March 2023

MSME or micro, small, medium enterprise is a type of business that plays a very important role for Indonesia’s economy. Due to its large number, making sure that those businesses have decent performances will be a huge priority for the country in order to make a stable and active economy for its people. However, compared to businesses who carry out activities in big cities, there are also SMEs in rural areas who do not have the convenience and opportunities of those entrepreneurs with supporting facilities and knowledge. Which is why the group/writer, who’s a participant of the community development program, aims to provide assistance to MSMEs in the Cageur Village region in Kuningan in order to identify problems or constraints and try to formulate solutions so that the business’ performance increases. The results of mentoring showed that it had affected the business positively in various aspects such as improvements in marketing, operation and finance. The group focused on the discussion of analyzing the impact of product packaging development using several methods and found a correlation between the group’s improvisation on the business’ packaging and the increased interest of consumers buying the products.
La relación entre el derecho internacional privado y el derecho internacional público
Authors: Mezarina García Silvio , Rosales Zamora Pablo
Published: March 2023

Este artículo pretende analizar la institución del orden público internacional, perteneciente al derecho internacional privado, en el marco de la relación entre esta disciplina y el derecho internacional público, considerando, dentro de este, al derecho internacional de los derechos humanos. El objetivo de esta investigación es estudiar cómo el orden jurídico internacional da forma a los contornos indeterminados del orden público internacional. El análisis emprendido acude, además, a la legislación interna peruana.
Profile Changes in Class III Malocclusion using Protraction Facemask in Indonesian Young Patients (Cephalometric Study)
Authors: Halim Himawan , Halim Ivan A.
Published: March 2023

Background:

The prevalence of Class III malocclusion is highest in Southeast Asia. In countries such as Malaysia and Indonesia, the prevalence is as high as 15.80%. Treatment timing and options are very important in treating Class III malocclusion. A protraction facemask or also known as reverse headgear is one of the most used appliances as an interceptive tool for Class III malocclusion in young patients.

Objectives:

This study aims to evaluate the profile changes in treating Indonesian young patients using a protraction facemask.

Methods:

The sample consisted of 63 subjects, 25 males and 38 females. Lateral cephalograms were traced and analyzed using CephaloMetrics AtoZ™ ver. 12 (Yasunaga Computer Systems, Co. Inc., Hanando-Minami, Fukui, Japan). A total of 16 traditional cephalometric measurements (13 skeletal measurements and 3 dental measurements) were used to describe changes between pretreatment and posttreatment cephalograms. All recorded data were analyzed using IBM SPSS version 21 (IBM Corporation, Armonk, New York, USA).

Results:

SNA (p˂0.030), ANB (p=0.000), and Wits appraisal values (p=0.000) showed significant differences out of all measurements. FMA and occlusal plane also showed changes and indicated that a facemask is helpful with treatment.

Conclusion:

Timing, duration, and patient compliance are very important in the management of Class III skeletal malocclusion using a protraction facemask. The use of facemask therapy among Indonesian pediatric patients resulted in an anterior and downward movement of the maxilla, backward rotation of the mandible, and a better orthopedic response.
THE EFFECTS OF GREEN CULTURE AND EMPLOYEE MOTIVATION ON GREEN WORKPLACE PRACTICE IN THE FOOD AND BEVERAGE INDUSTRY IN INDONESIA
Authors:   Universitas Pembangunan Nasional Jawa Timur, Rosyanti Daisy Marthina , Khoirotunnisa Fani ,   UPN Veteran Jawa Timur, Indonesia, Dewanti Mentari Clara ,   UPN Veteran Jawa Timur, Indonesia
Published: March 2023

The issue of green business practices has become an exciting topic to study in recent years. To achieve the SDGs, applying Green Human Resour­ces Management in green business practices is an essential aspect because of its role as a key factor in the company's success. Given that the Food and Beve­rage industry is one of the industries with the most millennial generation em­ployees, the support for millennial teamwork on green business practices is ur­gent in this study, "Are millennials involved in green practices." This study aimed to measure Green Workplace Practices among millennial employees thro­ugh the relationship between green motivation (intrinsic and extrinsic) and gre­en culture in the F&B industry in Indonesia. Data collection was done thro­ugh a questionnaire. The sample in this study was 67 respondents process­ed using the purposive sampling method and structural equation modeling tech­nique based on partial least squares. This study revealed that green motiva­tion research can significantly influence green workplace practices and that green organizational culture plays a role in moderating the relationship betwe­en green motivation and green workplace practices. This research has signifi­cant implications for managers to see positive consequences when organizati­ons adopt green practices. When organizations agree to reconstruct a green culture, they are not only doing their moral responsibility to society and the en­vironment but investing in business sustainability in the future. The resear­cher realized there are limitations in the research, both in terms of time and qu­antity of data on millennial employees in the Food and Beverage industry that have not be­en fully explored optimally. Considering that there are not many studies on similar themes and research findings can be used as a founda­tion for future re­search.
THE INFLUENCE OF FASHION INNOVATIVENESS ON BEHAVIORAL INTENTION MEDIATED BY BRAND IMAGE AND BRAND LOVE
Authors:   Faculty of Economics and Business, Brawijaya University, Indonesia, Miwa Nina Deskartika , Hussein Ananda Sabil ,   Faculty of Economics and Business, Brawijaya University, Indonesia, Rahayu Mintarti ,   Faculty of Economics and Business, Brawijaya University, Indonesia
Published: March 2023

The study aimed to investigate the impact of fashion innovation, brand image, brand love, and behavioral intention on Customers of Ria Miranda products in Malang. The research sample consisted of 200 purposively selected Customers of Ria Miranda products, with the data being analyzed using the partial least squares (PLS) methodology through SmartPLS. The research methodology involved an assessment of the internal consistency of the measurement models, the examination of outer models, the construction of path diagrams, and the testing of hypotheses. The study's findings suggest that fashion innovation directly impacts customer behavioral intention toward Ria Miranda products. Additionally, brand image and love mediate between fashion innovation and customer behavioral intention towards Ria Miranda products. To conclude, the study demonstrated the significant impact of fashion innovation on customer behavioral intention towards Ria Miranda products and the mediating role of brand image and brand love in this relationship. The high satisfaction level of these customers results in strong brand loyalty, further strengthened by brand love. The findings of this study indicate that customer behavioral intention can be formed if the fashion product management focuses on exploring the existing advantages of the brand, such as the dimension of fashion innovativeness while considering the brand image and the emotional feelings of the customer. When processed, a high-quality brand image and the emotional feelings of the customer play a full role as mediators in affecting behavioral intention.
Microencapsulation Combination of Nigella sativa and Cosmos caudatus Kunth and In Vitro Protein Denaturation Inhibition Assay
Authors:   Department of Chemistry, Faculty of Mathematics and Natural Science, Brawijaya University, Veteran Street, Malang, East Java, Indonesia, 65145, Safitri Anna , Zuhroh Nadiyah ,   Department of Chemistry, Faculty of Mathematics and Natural Science, Brawijaya University, Veteran Street, Malang, East Java, Indonesia, 65145
Published: March 2023

Microencapsulation is a method of coating the active ingredients to form microparticles that can be used as a drug delivery agent. This study aims to determine the effect of sodium tripolyphosphate (Na-TPP) concentration and the stirring time in microencapsulation process of extract combination of N. sativa and C. caudatus K., as well as the ability to inhibit protein denaturation. Microencapsulation was carried out with various concentrations (w/v) of Na-TPP 0.2%; 0.4% and 0.6% and stirring time of 60, 90, and 120 min. The optimum conditions of microencapsulation were obtained at 0.2% Na-TPP concentration and a stirring time of 90 min, with mean diameter particle sizes of 37.68 µm. Characterization using FTIR showed that microencapsulation was successfully conducted from the absorption of the P=O functional group at wavenumber 1200 cm-1 which was a typical absorption of Na-TPP compounds and the presence of CN absorption at wavenumber of 1352 cm-1 which is an absorption peak of chitosan. In addition, SEM showed the surface morphologies of the resulted microcapsules were mostly spherical shapes. From the protein denaturation inhibition assay, the IC50 values were resulted 491.67 µg/mL, 113.37 µg/mL, and 90.96 µg/mL, for microcapsules, extracts only, and sodium diclofenas as a reference, respectively.
Optical and electron-beam initiation of porous silicon films with different contents of oxidizer and graphene
Authors: Poberezhnaya U. M.  , Freiman V. M.  , Ilyushin M. A.  , Zegrya G. G.  , Fadeev D. V.  , Os'kin I. A.  , Morozov V. A.  , Grigor'ev A. Y.  , Savenkov G. G.
Published: March 2023

Laser and electron-beam initiation of the combustion process of energy-saturated composite films were studied. Composites were produced from porous silicon, a fluorine-containing polymer, and graphene. It is shown that the impact of a high-current electron beam of nanosecond duration does not lead to the excitation of the combustion process. Moreover, the process of film combustion during laser initiation is accompanied in some cases by the appearance of a zone of secondary flame and white smoke. Keywords: porous silicon, energy-saturated composite, laser initiation, electron-beam initiation, combustion.
Effect of plasma parameter profiles on a thermonuclear reaction operation
Authors: Gott   Yu.V.  , Yurchenko E.I.
Published: March 2023

The operation of a thermonuclear reactor on an alternative to D-T fuel (D-D, Cat-DD, D-3He, p-11B, p-6Li) requires a higher temperature of the fuel mixture and an increased plasma energy confinement time. It is shown that at a fixed power of thermonuclear reaction, an increase in the peaking of plasma parameters leads to a decrease in power, which is necessary to its addition heating. Moreover, the peaking of the plasma parameters leads to decrease of its radiation losses. All this reduces the requirements for the operating conditions of thermonuclear reactor. Keywords: thermonuclear reactor, alternative fuel, picking.
Study of functional characteristics of mesoporous electrodes of supercapacitors based on silicon-carbon films
Authors: Bogush I. Yu.  , Plugotarenko N. K.  , Myasoedova T. N.
Published: March 2023

The study of the supercapacitor electrodes based on silicon-carbon films obtained by electrochemical deposition from solutions with different ratios of methanol/hexamethyldisilane and addition of manganese and nickel salts was carried out using cyclic voltammetry, electrochemical impedance spectroscopy and impedance Nyquist plots simulation by equivalent circuits method. The predominance of mesopores in the electrode samples was confirmed by the functional density method. According to a scanning electron microscopy study, the surface morphology of the silicon-carbon films is highly developed due to the presence of three-dimensional agglomerates and "foliated" structures. The best retention of specific capacity after 450 charge/discharge cycles is observed for electrode samples containing manganese and nickel. Simulation of equivalent circuits showed that all types of electrodes have hierarchical pore structure. Ffter 450 charge/discharge cycles an increase in pore storage resistance and a decrease in transport pore resistance due to the activation of deeper pore levels is observed. The applicability of Peukert's law for the electrodes based on silicon-carbon films for prediction of electrode discharge time is shown. Keywords: Porous electrodes, silicon-carbon films, electrochemical impedance spectroscopy, equivalent circuit models, Peukert's law.
Methodological aspects of studying the parameters of elastic waves and controlling the standard form of acoustic emission in the field
Authors: Machmoudov  H. F.
Published: March 2023

To measure the energy of the source of acoustic pulses in the absolute scale of units (J) from the registered pulses, an analysis of the energy balance "source of pulses" -- "transmitting medium" -- "receiver of pulses" was carried out using a spectral analysis device. Comparison of two independent methods for determining the energy of elastic interaction (capacitive method and photoelasticity method) gave a discrepancy between the results of less than 12%. The spectral composition of the interaction energy is determined. The results make it possible to determine both the parameters of the signal source and the structure of the transmitting average signal conversion. To measure stresses in an elastic wave, a piezoelectric receiver, in which a piezofilm served as a sensitive element. This receiver differs from receivers made on the basis of piezoceramic elements, has a significantly lower non-linearity of the amplitude-frequency characteristic, since it has only two natural frequencies. Keywords: photoelasticity, elastic wave velocity, rock mass, concrete, acoustic emission.
Electrical and optical properties of thin-film bismuth ferrite
Authors: Dybov V.A.  , Kalinin Yu. E.  , Kamynin A. A.  , Kashirin M. A.  , Makagonov V.A.  , Nikonov A. E.  , Serikov D. V.  , Sitnikov A.V.
Published: March 2023

The optical and electrical properties of bismuth ferrite thin films obtained by high-frequency magnetron sputtering in an atmosphere of argon and oxygen (80%+20%) has been studied. Investigations of the optical properties have shown that for polycrystalline bismuth ferrite films the optical band gap is ~2.3 eV, which is in the range of given in the literature values. The dependences of the specific electrical conductivity on the magnitude of the electric field has been studied for the synthesized films. It has been established that the electrical conductivity does not depend on the electric field strength up to the value of E=2.1·106 V/m. The experimental results are discussed in terms of the model of charge carrier injection from aluminum electrode into the conduction band of bismuth ferrite. Keywords: electrical conductivity, strong electric fields, optical absorption coefficient, memristor effect.
Cathode erosion in a gas arc discharge at the threshold currents
Authors: Murzakaev A. M.
Published: March 2023

The results of experimental studies of the erosion rate of high-purity tungsten cathodes after pulsed arc discharges in a pure oil-free ultrahigh vacuum and in gases of various purities are reported. The erosion rate in high-purity argon does not change compared to the rate of erosion of electrodes in a pure oil-free vacuum. The rate of erosion in "technical" argon is 10-20% less than the rate of erosion of electrodes in an oil-free vacuum. The rate of erosion in "technical" nitrogen is 15-35% less than the rate of erosion of electrodes in vacuum. Particle sizes formed in gas arcs are smaller than those formed in vacuum arcs. Keywords: arc in gas, erosion rate, ecton mechanism, particles, electron microscopy
Investigation of the rate dependences of the stress of plastic flow and fracture of Mn2-Si steel at normal and elevated temperatures
Authors: Kanel G.I  , Garkushin G.V.  , Savinykh A.S.  , Razorenov S.V.  , Atroshenko S.A.
Published: March 2023

The Hugoniot elastic limit and spall strength of reactor Mn2-Si steel under shock compression were measured by recording and subsequent analysis of the wave profiles. The temperature-rate dependences of the resistance to high-strain rate and fracture of steel at normal and elevated temperatures are determined. The results of measurements of the strength characteristics of steel under spall are supplemented by a metallographic analysis of the fracture zone and compared with data for 15Kh2NMFA reactor steel and Armco iron. Keywords: ferrite-pearlite steel, shock waves, deformation, temperature, Hugoniot elastic limit, spall strength.
Evolution of structure of AlCoCrFeNi high-entropy alloy on irradiation by pulsed electron beam
Authors: Ivanov Yu. F.  , Gromov V. E.  , Konovalov S. V.  , Shliarova Y. А.
Published: March 2023

By the methods of modern physical materials science the change in structural-phase state of AlCoCrFeNi high-entropy alloy (HEA) of nonequiatomic composition obtained by the methods of wire arc additive technology (WAAM) after irradiation by electron beams with energy density of 10-30 J/cm2, durality of 50 μs, frequency 0.3 s-1 is studied. In the initial state the alloy had a dendritic structure indicating the inhomogeneous distribution of elements. It is shown that electron beam processing forms the structure of high-velocity cellular crystallization with cell size of 100-200 nm, along boundaries of which the nanodimensional (15-30 nm) inclusions of the second phase enriched in Cr and Fe atoms are located. Keywords: High-entropy alloy, electron beam processing, structure, phase composition.
Te-hyperdoped silicon layers for visible-to-infrared photodiodes
Authors: F.F. Komarov  , S.B. Lastovsky  , I.A. Romanov  , I.N. Parkhomenko  , L.A. Vlasukova  , G.D.Ivlev  , Berencen Y.  , A.A. Tsivako  , N.S. Kovalchuk  , Wendler E.
Published: March 2023

Silicon layers doped with tellurium up to concentration (3-5)·1020 cm-3 have been formed by ion implantation with subsequent pulsed laser annealing. It was shown that 70-90% of the introduced impurity is in the substitution position in the silicon lattice. Te hyperdoped silicon layers exhibit significant absorption (35-65%) both in the visible and near IR (1100-2500 nm) spectral ranges, and the absorption increases with increasing wavelength. The current-voltage and capacitance-voltage characteristics, as well as the photosensitivity of photodetectors based on Te-doped silicon layers have been presented and discussed. The residual structural defects in implanted Si layers have been investigated by deep-level transient spectroscopy. Keywords: silicon, hyperdoping, tellurium implantation, laser annealing, impurity subband, deep-level transient spectroscopy.
Possibility of creating a modular system for quantum key distribution in the atmosphere
Authors: Boev A. A.  , Vorobey S. S.  , Kazantsev S. Y.  , Kernosov M. Y.  , Kolesnikov O. V.  , Kuznetsov S. N.  , Mironov Y. B.  , Parshin A. A.  , Rudavin N. V.
Published: March 2023

The possibility of quantum key distribution in the atmosphere has been experimentally demonstrated by coupling commercially available quantum key distribution units designed for fiber-optic communication lines with atmospheric optical communication terminals. For distances up to 3100 m, data on losses in a quantum channel on an optical path were obtained and the influence of systems for intelligent adjustment of atmospheric communication terminals on the synchronization system of quantum communication blocks was studied. It has been established that failures of synchronization systems in the case of quantum key distribution in the atmosphere at distances greater than 10 m are due to the peculiarities of the algorithm implemented in the quantum communication unit. Keywords: quantum key distribution, atmospheric optical communication lines, FSO, decoy-state BB84 protocol, polarization coding.
An influence of mechanical stresses on the magnitude of the internal field in lead zirconate titanate thin films
Authors: Valeeva A. R.  , Kaptelov E. Yu.  , Senkevich S. V.  , Pronin I. P.  , Nemov S. A.  , Pronin V. P.
Published: March 2023

In self-polarized lead zirconate titanate thin films formed on platinized silicon substrates, a significant increase in the internal electric field was observed as a result of long-term aging. To explain this phenomenon, a mechanism is proposed for the formation of the internal field associated with the diffusion of charged oxygen vacancies, which, in turn, is due to the action of a mechanical stress gradient. The diffusion coefficient of charged oxygen vacancies was estimated to be ~ 3·10-16 cm2/s. Keywords: thin films, lead zirconate titanate, internal field, Gorsky effect.
Optical excitation and control of extended orbits in quadrupole traps
Authors: Rudyi S. S.  , Rybin V. V.  , Shcherbinin D. P.  , Rozhdestvensky Y. V.  , Kosternoi I. A.
Published: March 2023

In the present work a formation of extended orbits of single charged particles in a linear radiofrequency trap under the action of the light pressure force of laser radiation is considered. The conditions for the formation of extended orbits depending on the characteristics of the laser radiation and the object of localization are determined. Keywords: ion traps, quadrupole traps, light pressure, extended orbits, period-doubling bifurcation, nonlinear dynamics.
Nonreciprocal backscattering of millimeter waves by lithium niobate crystals when ultrasonic vibrations are excited in them
Authors: Sutorikhin V. A.  , Malyutin N. D.  , Pozdnyakov V. S.
Published: March 2023

The results of experimental studies of millimeter waves backscattering with a frequency of 33 GHz by lithium niobate crystals using an installation based on a Doppler radar (microwave sensor) are presented. The measurements were carried out when ultrasonic vibrations with a frequency of 50.3 kHz were excited in the crystals and in their absence. It is found that due to elastic ultrasonic vibrations in the crystals, the phase modulation of the reflected wave from the crystal-dielectric-metal system occurs, as a result of which the effect of non-reciprocity of backscattering occurs. Detection of the phase difference between the voltage of the backscattering wave and the voltage of the incident (radiated) wave gave a useful signal level up to 50 dB higher than the noise level of the receiving and transmitting path of the microwave sensor. We established experimentally that the amplitude and frequency of the maximum of the envelope of the backscattering spectral components depends on the angle between the crystal symmetry axes and the vector polarization of the incident electromagnetic wave and on the orientation of the crystal in space. These measurements provide qualitative information about the piezoelectric properties of the crystal material and the presence of elastic waves. Keywords: Nonreciprocal backscattering, lithium niobate crystals, ultrasonic vibrations, Doppler radar, phase detection.
Nature of the local environment of germany atoms in amorphous films (GeTe)-=SUB=-x-=/SUB=-(Sb-=SUB=-2-=/SUB=-Te-=SUB=-3-=/SUB=-)
Authors: Marchtnko A.V.  , Terukov E.I.  , Nasredinov F.S.  , Petrushin Yu.A.  , Seregin P.P.
Published: March 2023

Using Messbauer spectroscopy on 119Sn impurity atoms, it was demonstrated that in amorphous (GeTe)x(Sb2Te3) films (where x=0.5, 1, 2, 3) tin atoms replace atoms of tetravalent germanium, which forms a tetrahedral system of chemical bonds with atoms in its local environment. In crystalline films, tin replaces divalent six-coordinated germanium in positions 4b of the NaCl-type crystal lattice. Keywords: amorphous films, phase memory, Messbauer spectroscopy.
Registration of high-frequency relief-phase holographic structures on the PFG-04 photographic material
Authors: Ganzherli N. M.  , Gulyaev S. N.  , Maurer I. A.  , Arkhipov A. V.
Published: March 2023

The paper proposes a new variant of processing photographic plates for holography based on dichromed gelatin PFG-04 (produced by JSC "Slavich Company", Pereslavl-Zalessky) for manufacturing high-frequency relief-phase holographic gratings with a spatial frequency of up to 1500 mm-1. The technology is based on the selective destructive effect of shortwave UV radiation on gelatin and subsequent etching of the layer with various reagents. The relief-phase high-frequency holographic gratings with the maximum diffraction efficiency of 67% were obtained on PFG-04 photographic plates for the first time. Keywords: holographic relief-phase gratings, dichromed gelatin, photographic plates PFG-04, short-wave UV radiation, glacial acetic acid
Impact of transverse optical confinment on performance of 1.55 μm vertical-cavity surface-emitting lasers with a buried tunnel junction
Authors: Blokhin S.A.  , Bobrov M. A.  , Blokhin A.A.  , Maleev N.A.  , Kuzmenkov A.G.  , Vasyl’ev A.P.  , Rochas S. S.  , Babichev A. V.  , Novikov I. I.  , Karachinsky L. Ya.  , Gladyshev A. G.  , Denisov D. V.  , Voropaev K. O.  , Egorov A. Yu.  , Ustinov V. M.
Published: March 2023

The impact of transverse optical confinement on the static and spectral characteristics of 1.55 μm vertical-cavity surface-emitting lasers (WF-VCSEL) with a buried tunnel junction (BTJ) n++-InGaAs/p++-InGaAs/p++-InAlGaAs, implemented using molecular-beam epitaxy and wafer fusion. It was found that for VCSELs with a tunnel junction (TJ) etching depth of 15 nm, the single-mode lasing occurs up to 8 μm BTJ mesa size due to a relatively weak lateral optical confinement, while the effect of a saturable absorber (SA) appears when the BTJ mesa size is less than 7 μm. Enhancing lateral optical confinement by increasing the BTJ etching depth up to 20 nm leads to suppression of the SA effect at the BTJ mesa size of 5-6 μm, but simultaneously limits the maximum single-mode optical power. According to obtained results an increase in the spectral mismatch between the maximum of the gain spectrum of the active region and the resonance wavelength of the WF-VCSEL up to ~ 35-50 nm will make it possible to suppress the undesirable SA effect in a wide range of the BTJ mesa sizes maintaining the single-mode lasing. Keywords: vertical-cavity surface-emitting laser, wafer fusion, molecular beam epitaxy, single-mode operation, saturable absorber.