bluuebunny/crossref_metadata_2025 huggingface dataset:
The success of robot-assisted cystectomy in the treatment of muscle-invasive bladder cancer
Authors: Pavlov V. N. , Urmantsev M. F. , Bakeev M. R.
Published: August 2022

Background. Bladder cancer is a serious problem of modern oncourology due to the annual increase in the number of diagnosed malignant neoplasms of the urinary system. High-risk muscle-invasive and non-muscle-invasive forms are subject to surgical treatment, while open radical cystectomy serves as the “gold standard”. Laparoscopic and robot-assisted radical cystectomy are serious competitors to this method. To date, the robotic method of removing the bladder is the least studied, despite the fact that it seems to be the most technologically advanced and modern.

Aim. To analyze the own results of the use of robot-assisted interventions in high-risk musculoskeletal and non-musculoskeletal invasive bladder cancer, as well as to study the literature on the use of robot-assisted radical cystectomy in the treatment of malignant neoplasms of the bladder.

Materials and methods. A prospective study was conducted on the basis of the clinic of the Bashkir State Medical University with the participation of 70 patients who were diagnosed with bladder cancer (T1–T4). The subjects underwent a robot-assisted radical cystectomy with various variants of urine derivation.

Results. At the end of the study, the outcomes after robot-assisted radical cystectomy were analyzed and evaluated. The primary endpoints were 30- and 90-day complications of the Clavien–Dindo system. According to secondary indicators, robot-assisted radical cystectomy demonstrated a low duration of surgery, intraoperative blood loss.

Conclusion. Robot-assisted radical cystectomy is a serious competitor to open and laparoscopic interventions for early and long-term perioperative indicators. This technique has shown its profitability in the treatment of bladder cancer, demonstrating a sufficient level of effectiveness and safety.
Guideline on trimodal therapy of bladder cancer (Nevskiy consensus 2021)
Authors: Novikov R. V. , Novikov S. N. , Novikov A. I. , Petrov S. B. , Protsenko S. A. , Protoshchak V. V. , Popov S. V. , Shkolnik M. I. , Shpilenya E. S. , Kurenkov A. V. , Sokurenko V. P. , Orlova R. V. , Nosov А. K. , Korol V. D. , Latipova D. Kh. , Mikheeva Yu. V. , Kanaev S. V.
Published: August 2022

The aim of this work was to clarify and extend the existing clinical guidelines on organ-sparing treatment of muscleinvasive bladder cancer. The standard protocol of radical conservative treatment for muscle-invasive bladder cancer includes transurethral resection of the bladder, external beam radiotherapy with simultaneous chemotherapy (radiosensitization), which is usually referred to as trimodal therapy. The implementation of trimodal therapy into routine practice in Russia is limited due to the lack of distinct criteria for each of the stages. The involvement of surgeons, radiation oncologists, and chemotherapists, on the one hand, provides the required multidisciplinary approach to cancer treatment; on the other hand, it might impede the entire algorithm. To address this problem, specialists from the Department of Radiology (project moderators), Department of Cancer Urology, and Department of Chemotherapy of N.N. Petrov National Medical Research Center of Oncology under the auspices of Saint Petersburg Oncological Research Society formed a group of experts, including radiation oncologists, urologists, and chemotherapists from federal and local cancer (educational) institutions of Saint Petersburg who had an experience of treating muscle-invasive bladder cancer. The guideline was developed with the consideration of available guidelines published by leading professional associations of radiotherapy and oncology (urological), research articles, and own experience.
Prognostic significance of sPD-1/sPD-L1 in renal cancer depending on the phenotype of tumor and stromal cells
Authors: Kovaleva O. V. , Gratchev A. N. , Makarova E. I. , Bezhanova S. D. , Stilidi I. S. , Matveev V. B. , Kushlinskii N. E.
Published: August 2022

Background. The search for new prognostic markers of renal cell carcinoma is an urgent problem of oncourology. Modern studies demonstrate the need for a comprehensive assessment of the clinical and prognostic significance of many markers.

Aim is a comprehensive analysis of the prognostic significance of soluble forms of PD-1 and PD-L1 (sPD-1 and sPD-L1) depending on the phenotype of tumor cells and the microenvironment.

Materials and methods. The study included tumor tissue and serum samples from 54 patients with renal cell cancer and from 67 healthy donors. The concentrations of sPD-1 and sPD-L1 were determined in blood serum using ELISA. Tissue expression of PD-L1, PU.1, CD3, and CD20 was assessed by immunohistochemistry. To determine statistically significant differences in independent groups, the Mann–Whitney test and Fisher’s exact test were used. Overall survival was analyzed by constructing survival curves using the Kaplan–Meier method. Differences were considered statistically significant at p <0.05.

Results. Increase of sPD-L1 concentration in serum from patients with renal cell carcinoma compared with healthy donors was demonstrated. The highest concentration of the soluble form of the PD-1 receptor was observed in serum from patients with the non-clear cell renal cell carcinoma. High levels of sPD-L1 in serum and PD-L1 in tumor cells are associated with disease progression (advanced stage, higher malignancy, as well as the presence of regional metastases). It has been shown that the high content of PU.1+ and CD20+ cells in the tumor stroma are significant factors of unfavorable prognosis. No prognostic significance was found for both sPD-L1 and PD-L1 expressed in tumor tissue. However, analysis of a combination of these markers showed that the high concentration of sPD-L1 together with the high tissue expression of PD-L1 is an extremely unfavorable factor.

Conclusion. Analysis of sPD-L1 concentration and tissue expression of PD-L1 in combination is a new approach for assessing the prognosis of renal cell carcinoma.
Prerequisites for lithogenesis after radical cystectomy: literature review
Authors: Prosyannikov M. Yu. , Kaprin A. D. , Apolikhin O. I. , Alekseev B. Ya. , Sivkov A. V. , Shevchuk I. M. , Voytko D. A. , Anokhin N. V.
Published: August 2022

Recently, there has been a worldwide increase in the incidence of bladder cancer. Improved morphological diagnostics, increased surgical activity and availability of chemotherapy allowed reducing the one-year mortality rate and increasing the five-year survival rate. However, at the same time, there was a struggle with complications arising after the treatment. According to the world and domestic literature, it is noted that with an increase in life expectancy in patients who underwent radical cystectomy with intestinal urine derivation, an almost twofold increase in the frequency of complications, including the formation of urinary stones, is recorded. Previous studies have shown that about 60 % of the stones identified in this category of patients are infectious, and 40 % formed because of metabolic disorders, which have their own characteristics with different types of urine derivation. In this work, we present an overview of the predisposition for stone formation in patients who underwent cystectomy for musculoinvasive bladder cancer, taking into account the type of urine derivation.
Pattern of adverse drug reactions to anticancer drugs at an apex hospital in south India: A retrospective study
Authors: George Deepthi Mary , Palatty Princy Louis
Published: August 2022

Cancer chemotherapy is rampant as cancer is the 2nd most common cause of global mortality. It is challenged by a horde of adverse drug reactions (ADRs) and adverse events. A proper study of these ADRs is very crucial to limit their occurrences and thereby ameliorate the sufferings of the patients. Our study was to assess the frequency, nature and profile of the ADRs with anticancer drugs. A retrospective analysis of the ADR data collected over a period of 5 years was considered. Demography, drug related changes and clinical details of the patients were recorded and analysed. A total of 1145 ADR events were reported during the study period of January 01, 2017 to December 31st 2021 of which 232 cases (20.26 %) were due to anticancer drugs. The majority of the ADRs were accounted in females and in the elderly age group (>60 years). The commonly reported ADRs included breathing difficulty, chest discomfort, itching all over the body, numbness, neuropathy, mucositis and hand foot syndrome. The most common drugs that caused ADRs were Platinum coordination complex drugs, Taxanes, Rituximab and pyrimidine antagonists like Capecitabine and Gemcitabine. Causality assessment done using WHO-Uppsala Monitoring Centre causality assessment scale which showed 69.4% cases as “probable”, 29.3% cases as “possible” and 1.3% as “certain”. Severity assessed using the modified Hartwig and Siegel scale showed most of the cases as of moderate severity. Most of the ADR events in our study was manageable although a few required the withdrawal of the causative drug. Rigorous monitoring and adequate reporting are very crucial for the prompt identification, assessment and timely management of ADRs in the patients receiving chemotherapy so as to improve the quality of life in these patients.
Dutch Regions from the Batavi and Belgae to the Belgian Revolution of 1830
Authors: Shatokhina-Mordvintseva Galina , Khorosheva Aleksandra , Namazova Alla , Mayzlish Anna
Published: August 2022

Учебное пособие подготовлено коллективом сотрудников Института всеобщей истории Российской академии наук в рамках проекта по подготовке ИУМК «История». В пособии с древности до 1830 г. изложены важнейшие процессы и события истории нидерландских областей — территории, где в настоящее время расположены государства Бельгия, Нидерланды и Люксембург. Выявляя взаимосвязи и общие тенденции, характерные для Исторических Нидерландов, авторы обращают внимание на уникальные особенности отдельных областей и их этническое и культурное многообразие. Целостное представление о развитии региона вписано в контекст важнейших событий европейской истории. Учебное пособие снабжено вопросами и заданиями к каждой теме, словарем понятий и терминов, генеалогическими таблицами, иллюстративным и картографическим материалом. В отдельных врезках дается дополнительная информация о наиболее значимых явлениях нидерландской истории, известных политических и общественных деятелях, представителях науки и культуры. Учебное пособие предназначено для старших классов средней школы (как для фрагментарного изучения истории по базовому курсу, так и в качестве элективного курса), а также может применяться в качестве дополнительного учебного материала в рамках программ бакалавриата и магистратуры по «Всеобщей истории» и «Страноведению» в высших учебных заведениях.
Рослини для біофільного дизайну в зеленому будівництві
Authors: Кривомаз Тетяна Іванівна , Тищенко Оксана Василівна , Сулейманов Ісмет Емільович
Published: August 2022

Досліджено шляхи використання рослин для біофільного дизайну в зеленому будівництві. Мета. Визначити актуальні напрямки практичного застосування принципів біофільного дизайну в контексті зеленого будівництва фахівцями у галузях будівництва, архітектури та садово-паркового господарства для покращення побудованого середовища та урбанізованого простору. Методологія. Інноваційні технології зеленого будівництва та принципи біофільного дизайну. Результати. Проаналізовано сучасні напрямки розвитку зеленого будівництва і біофільного дизайну та виявлено сфери перетину обох концепцій. Вони тісно пов’язані із захистом здоров’я та безпеки людей, підвищенням якості та комфорту побудованого середовища, збереженням довкілля. Обидві технології також передбачають функціональне та естетичне використання рослин. Оцінено перспективи та ризики застосування рослин на урбанізованих територіях. Встановлено перспективні напрямки розвитку біофільного дизайну в узгодженні з концепцією зеленого будівництва. Наукова новизна. Визначено спільні соціальні, екологічні та економічні переваги зеленого будівництва та біофільного дизайну. Встановлено, що внаслідок застосування цих технологій підвищується комфортність проживання навіть в умовах підвищеної щільності на урбанізованих територіях. Виявлено перспективні напрямки біофільних методик в узгодженні з міжнародною тенденцією зеленої трансформації міст внаслідок пандемічних загроз. Практична значущість. Наведено переліки видів рослин для покращення мікроклімату та очищення повітря урбаністичних просторів, для вертикального озеленення інтер’єрів та екстер’єрів. Охарактеризовано закономірності впливу рослин на здоров’я та самопочуття людей. Рекомендовано керуватись вимогами функціональності та безпеки, дотримуватись раціонального балансу між місцевими рослинами та видами з інших регіонів на користь перших.
Еколого-естетичний підхід до дизайну об’єктів збору сміття в міському просто-рі
Authors: Рихліцька Оксана Дмитрівна , Косик Оксана Іванівна , Беззубцева Марія Сергіївна
Published: August 2022

Розглядаються еколого-естетичні принципи створення місць збору сміття в сучасному міському просторі. Проаналізовано нові ідеї облаштування і дизайну смітників та контейнерів для побутових відходів в європейському та вітчизняному урбаністичному середовищі. Продемонстровано їх практичну та естетичну роль у міському ландшафті.В статті представлені останні розробки нових систем для зберігання і транспортування побутових відходів різного типу та затрати на їхнє впровадження в маштабах сучасного міста на прикладі міста Києва. Вирішення проблеми дизайну смітників у зоні міста має ряд переваг. В першу чергу це екологічна сторона питання. В естетично привабливу і функціональну урну сміття викидатимуть з більшою охотою. По друге — економічний аспект. Впроводження сучасних технологій в сферу зберігання та переробки побутових відходів позитивним чином позначиться на економіці міста і потребуватиме менше коштів на обслуговування системи збору, зберігання та переробки сміття. По третє — покращення естетичного вигляду смітників позитивним чином позначиться на розвитку туристичного бізнесу. Дизайн смітників, як і дизайн елементів благоустрою взагалі, пов’язаний за стилем виконання та матеріалами з візуальним характером відповідної громадської зони. Для збагачення простору тематичного середовища та посилення вражень можуть використовуватись креативні тематичні стилізовані смітники.
Sobre a capa
Authors: Unoesc Editora
Published: August 2022

Sobre a capa
Formação de professores que ensinam matemática em uma perspectiva de complexidade: discussão agregando fragmentos experienciais
Authors: Guérios Ettiène
Published: August 2022

Apresento pressupostos que fundamentam uma perspectiva complexa de formação de professores que ensinam matemática. A complexidade pertence aos estudos contemporâneos sobre cognição e desenvolvimento humano. Encontra ressonância na comunidade científica, envolvida com discussões inter e transdisciplinares, nos diferentes âmbitos formativos. Este artigo tem o objetivo de discutir questões relativas à formação de professores que ensinam matemática em uma perspectiva de complexidade, conforme postula Edgar Morin. De natureza analítica e reflexiva, tomo a ideia de conhecimento pertinente como âncora teórica e o pensamento complexo como linha matriz sob a qual analiso fragmentos de experiências formativas vividas por uma professora que ensina matemática na Educação Básica e fragmentos de experiências vividas por uma aluna adulta tentando aprender matemática. Ambas não têm vínculo entre si. Da primeira, analiso o reflexo, em seus alunos, de seu processo de formação. Da segunda, analiso o reflexo da ação de sua professora em seu processo de aprendizagem. Adoto a ideia do pensamento complexo como articulante e multidimensional, em que articular, relacionar e contextualizar são movimentos intrínsecos ao fazer docente. Como resultado, apresento indicativos de que a densidade da aprendizagem em matemática é vinculada a princípios didáticos, desenvolvidos pelos professores em seus processos formativos, que vão da prescrição pedagógica, em um extremo, à problematização de situações contextualizadas, porquanto pertinentes, em outro.
O empresariamento da educação superior e as tecnologias de intensificação do trabalho docente
Authors: Bechi Diego
Published: August 2022

O empresariamento da educação superior, preconizado pela racionalidade capitalista (toyotista/neoliberal) e impulsionado pelas novas tecnologias digitais, têm provocado o esfacelamento da fronteira entre trabalho e vida privada, elevando o estresse, o sofrimento e o adoecimento do trabalhador docente. Tendo em vista essa assertiva, a pesquisa tem por objetivo analisar os mecanismos empregados pela racionalidade empresarial, em ascensão no âmbito da educação superior, para ampliar o desempenho do trabalhador docente, de modo a sujeitá-los a jornadas extenuantes e a ritmos intensos de trabalho. Trata-se de um estudo exploratório, quanto aos objetivos, e bibliográfico, centrado no materialismo histórico-dialético, quanto aos procedimentos. Nesse sentido, a primeira seção versa sobre os mecanismos de “captura” e manipulação da subjetividade do trabalhador pelo modelo de gestão da produção aos moldes toyotistas e pela flexibilização dos direitos trabalhistas imposta pelo projeto hegemônico neoliberal. Na sequência, busca-se compreender o processo de expansão da racionalidade “empresarial competitiva” e de aprofundamento da ideologia do empreendedorismo no âmbito da educação superior. Para isso, tornam-se objetos de análise as tecnologias políticas de privatização (endógena e exógena) e as mudanças nas condições de trabalho docente, que, por sua vez, contribuem para a formação de uma subjetividade empresarial (produtivista e concorrencial). Por fim, analisam-se os mecanismos de implementação de uma cultura performativa, determinada pelo poder dos números e da lucratividade, cujas implicações recaem sobre a jornada de trabalho, os projetos de vida e a saúde física e emocional dos trabalhadores docentes da educação superior.
Zasada ogólna pisemności w postępowaniu podatkowym
Authors: Masternak Marian
Published: August 2022

Przedmiotem artykułu jest analiza zasady pisemności, będącej jedną z zasad ogólnych postępowania podatkowego. Celem opracowania jest ustalenie i wyjaśnienie istoty tej zasady oraz wymogów związanych z jej realizacją, z uwzględnieniem niedawnych zmian przepisów konstytuujących wymienioną zasadę, w tym nowo uregulowanych sposobów uwierzytelniania pism utrwalonych w postaci papierowej lub elektronicznej. Autor podejmuje próbę odpowiedzi na pytanie, czy zmiany te ograniczają się do uporządkowania i ujednolicenia terminologii stosowanej w Ordynacji podatkowej i w ustawie o doręczeniach elektronicznych, czy też na nowo kształtują treści zasady pisemności. W artykule zawarta jest też ocena obecnej regulacji oraz wnioski de lege ferenda dotyczące tej zasady.
Análisis y evaluación de mercados internacionales de la miel natural
Authors: Castro Fajardo Hermes , Otálora Gómez Lina María , Chavarro Miranda Fernando
Published: August 2022

La investigación tiene como objetivo clasificar los países para orientar la internacionalización de los productores de miel natural en Colombia al aplicarles la matriz de atractividad y competitividad, ya que el mercado actual exige a las empresas acciones que generen ventajas competitivas para enfrentar la creciente competencia internacional y aprovechar sus oportunidades. La matriz de atractividad y competitividad, aquí explicada, orienta la decisión acerca de a dónde y cómo entrar en mercados internacionales, para ello, se adaptó la matriz Boston Consulting Group  (BCG) en sus ejes originales por el consumo per cápita y crecimiento del mercado para ubicar a los países objetivo en cuadrantes acordes con el ciclo de vida del producto (introducción, crecimiento, madurez y obsolescencia) o con ejes de consumo per cápita y precio aparente para ubicar las estrategias competitivas (liderazgo en costos, diferenciación y enfoque), lo que facilita el diseño de los planes de mercadeo internacional. La investigación muestra que Francia se posiciona como el mercado de mayor potencial para ser abordado con la posibilidad de los productores nacionales para ofrecer propuestas de valor basadas en la diferenciación y enfoque.
Repair of traumatic flank hernia with mesh strip suture: a case report
Authors: Lee Shin Ae , Chang Ye Rim
Published: August 2022

Traumatic flank hernia is a relatively rare hernia. We report a case of a male patient with severe multiple trauma, including abdominal injury, who presented with flank hernia 3 years postinjury. The hernia was successfully repaired using mesh strips suture, and at the 12-month follow-up, no complications or recurrence was found. Our findings indicate that when it is difficult to secure a sufficient operative field for mesh anchoring in a traumatic flank hernia, a technique of sutured repair with mesh strips may be considered as a treatment option as it requires less dissection. Compared to the conventional planar mesh repair, this technique decreases the risk of injuries and ischemic necrosis of the surrounding tissues.
Fetal Macrosomia and Associated Factors to Perinatal Adverse Outcomes, in Yaounde, Cameroon : A Case Control Study
Authors: Njom Nlend Anne Esther , Gwodog Josepha , Sandie Arsene Brunelle
Published: August 2022

To Identify risk factors of perinatal complications amongst macrosomic babies in a reference hospital structure.We conducted a case-control institutional based study. Cases and controls of singleton livebirths were extracted from the maternity registry from January 2017 to December 2019 The case population consisted of mother and child macrosomic couples with perinatal complications. The control group consisted of couples without perinatal complications. Matching was done on age and sex. The main primary end point was the risk factors for complications. Data were analyzed using R, software version3.0 in adjusted and unadjusted analysis with p<0.05 threshold considered statistically significant.Out of 362 couples, we had 186 cases and 176 controls. Maternal age ≥30 years (p=0.024); non-screening for gestational diabetes (p=0.027); history of caesarean section (p=0.041); weight gain ≥16 kg (p<0.001); maternal HIV (p=0.047); birth weight ≥4500g (p=0.015) and birth height ≥ 52.7 ±1.7cm (p=0.026) were risk factors. The delivery of a macrosomic baby remains problematic in this setting. The improvement of the maternal-fetal prognosis requires quality prenatal surveillance and management by a multidisciplinary perinatal team involving obstetricians, endocrinologists and neonatal pediatricians.
Pengembangan media pembelajaran biologi berbentuk buku saku dilengkapi peta konsep pada materi plantae siswa kelas x sma.
Authors: Elpina Nisi , Deswati Lisa , Sari Rona Taula
Published: August 2022

Penelitian ini bertujuan untuk menghasilkan buku saku yang dilengkapi dengan peta konsep materi plantae siswa kelas X yang valid dan praktis. Adapun yang melatarbelakangi penelitian ini adalah masih banyak siswa yang kurang aktif dalam proses pembelajaran serta hasil belajar siswa yang relatif rendah. Jenis penelitian ini adalah penelitian dan pengembangan yang merupakan metode penelitian yang digunakan untuk menghasilkan produk tertentu. Jenis penelitian ini menggunakan 3 tahapan model 4-D yaitu define, design, dan develop. Berdasarkan penelitian yang dilakukan, dihasilkan media pembelajaran biologi berupa buku saku yang dilengkapi dengan peta konsep sangat valid sebesar 3,67 oleh validator dan praktik oleh guru sebesar 83,75% dan oleh siswa sebesar 86% dengan kriteria praktik. Dan peneliti juga menyarankan agar peneliti lain dapat menjadikan penelitian ini sebagai referensi penelitian, sedangkan guru dan siswa dapat menjadikan buku saku ini sebagai salah satu sumber belajar.

 

Development of pocketbooks equipped with concept map on plantae material for high school students. This research aims to produce a pocket book equipped with a concept map on plantae material of valid and practical X grade students. As for the background of this research is that many students are still less active in the learning process as well as relatively low student learning outcomes. This type of research is research and development which is a research method used to produce certain products. This type of research uses 3 stages of 4-D models namely define, design, and develop. Based on the research conducted, produced biology learning media in the form of pocketbooks equipped with a very valid concept map of 3.67 by validators and practical by teachers by 83.75% and by students by 86% with practical criteria. And the researchers also suggested that other researchers could make this study a reference for research, while teachers and students could make this pocketbook as one of the learning sources.
Can digital economic development facilitate employment growth? Empirical evidence from China
Authors: Huang Huan , Chen Yu-Xiang , Xiao Yi , Xiang Xin , Tang Xiao
Published: August 2022

With the gradual disappearance of the demographic dividend, the recurring world financial crisis, and the sudden outbreak of the new crown epidemic, a variety of complex factors have caused the Chinese job market to be under unprecedented pressure. In recent years, the development of the digital economy does not seem to be affected by the above factors. Can the fast-growing digital economy ease the current employment pressures facing China? In this paper, through the establishment of an index system of digital level of economic development, use of Chinese 30 provinces from 2011 to 2019, the digital economy data, calculate the annual digital economy development level of each province and explore the impact of digital economy development on employment. The findings show that the level of digital economy development is higher in the eastern coastal regions of China than in the western inland regions; through the development of the digital economy, the employment level can be effectively enhanced. This conclusion persisted after a series of robustness tests. The mechanism test finds that digital economy development affects the change of employment volume by influencing the level of education. Through further research, it is found that there is a threshold effect on the impact of the digital economy on employment in the central and eastern regions. This may be because there is a large variation in economic levels and an imbalance in education between the central and western regions, creating a certain amount of over-education. Finally, on the basis of the digital economy development and the current situation of employment of China now, this article from the perspective of the development of digital economy, education levels, improve some targeted suggestions are put forward.
Evaluation of the quality of multiple-choice questions according to the students' academic level
Authors: Iñarrairaegui Mercedes , Fernandez-Ros Nerea , Lucena Felipe , Landecho Manuel F , Garcia Nicolas , Quiroga Jorge , Herrero J. Ignacio Ignacio
Published: August 2022

Background. One of the most important challenges in medical education is the preparation of multiple-choice questions able to discriminate between students with different academic level. Average questions may be very easy for students with good performance, reducing their discriminant power in this group of students. The aim of this study was to analyze if the discriminative power of multiple-choice questions is different according to the students' academic performance. Methods. We retrospectively analyzed the difficulty and discrimination indices of 257 multiple-choice questions used for the end of course examination of pathophysiology and analyzed whether the discrimination indices were lower in students with good academic performance (group 1) than in students with moderate/poor academic performance (group 2). We also evaluated whether case-based questions maintained their discriminant power better than factual questions in both groups of students or not. Comparison of the difficulty and discrimination indices between both groups was based on the Wilcoxon test.Results. Difficulty index was significantly higher in group 1 (median: 0.78 versus 0.56; P < 0.001) and discrimination index was significantly higher in group 2 (median: 0.21 versus 0.28; P < 0.001). Factual questions had higher discriminative indices in group 2 than in group 1 (median: 0.28 versus 0.20; P < 0.001), but discriminative indices of case-based questions did not differ significantly between groups (median: 0.30 versus 0.24; P=0.296). Conclusions. Multiple-choice question exams have lower discriminative power in the group of students with high scores. The use of clinical vignettes may allow to maintain the discriminative power of multiple-choice questions.
Fixed Point Results in Soft Rectangular B-metric Space
Authors: Sonam Sonam , Chauhan C.S. , Bhardwaj Ramakant , Narayan Satyendra
Published: August 2022

The fundamental goal of the proposed work is to present the concept of soft rectangular b-metric space by generalising the notions of rectangular metric space and b-metric space, as well as to examine certain basic and topological aspects of the underlying spaces. Also, fixed point theorems for maps satisfying essential criteria in space are established, which generalises well known results in fixed point theory. In addition, some congruous examples are provided to clarify the concept of said space structure.Mathematics Subject Classification: 47H10, 54H25.
The first nonclassical Tc1 transposon discovered in yeast
Authors: Gao Shan , Chang Jia , Mi Dong , Yau Tung On , Liu Chang , Cui Jianlin , Xue Huaijun , Ruan Jishou , Bu Wenjun , Duan Guangyou
Published: August 2022

Background
Identification of transposons or retrotransposons is still a difficult task and can not be accomplished without specialist knowledge. Tc1/mariner is a superfamily of DNA transposons that have been discovered in animals, plants, and fungi. Tc1/mariner transposons are probably the most widespread DNA transposons in nature. However, Tc1 transposons have not been identified and characterized in yeast and their nucleotide sequences are not available in public databases.
Results
In the present study, we reported the discovery of two intact Tc1 transposons in yeast and. filamentous fungi, respectively. The first one, named Tc1-OP1, can be used as a signature of Ogataea parapolymorpha. The second one, named Tc1-MP1, represents a subfamlily of Tc1 transposons in Rhizopus, Mucor, Circinella, etc. Notablely, Tc1-OP1 may encode a protease and a transposase, challenging the classical model of DNA transposons.
Conclusions
Tc1-OP1 is the first reported Tc1 transposon in yeast. Tc1-OP1 and Tc1-MP1 can be used for the identification and characterization of Tc1 transposons in future studies. The discovery of Tc1-OP1 revealed a nonclassical model of DNA transposons, which could challenge and enrich fundamental concepts of DNA transposons.
Acceptability and Feasibility of a Mobile Health Application for Enhancing Public Private Mix for TB care among Healthcare workers in Southwestern Uganda
Authors: Tumuhimbise Wilson , Atwine Daniel , Kaggwa Fred , Musiimenta Angella
Published: August 2022

Background: Mobile health interventions can potentially enhance public-private linkage for tuberculosis care. However, evidence about their acceptability and feasibility is lacking.
Objective: To assess the initial acceptability and feasibility of a mobile health application for following up presumptive tuberculosis patients referred from private to public hospitals.
Methods: A total of 22 healthcare workers from three private hospitals and one public hospital in southwestern Uganda were trained and received Tuuka mobile application for a period of one month for testing. Testing focused on a variety of issues such as referring cases by private healthcare workers and receiving cases by public healthcare workers, and sending SMS reminders to the referred patients by filling the digital referral forms inbuilt within the app. Study participants participated in qualitative semi-structured in-depth interviews on the acceptability and feasibility of this app. An inductive, content analytic approach, framed by the unified theory of acceptance and use of technology model, was used to analyze qualitative data. Quantitative feasibility metrics and the quantitative assessment of acceptability were analyzed descriptively using STATA.
Results: Healthcare workers found the Tuuka application acceptable and feasible with a mean total system usability scale score of 98 (SD 1.97). The application was perceived to be useful in reminding referred patients to adhere to referral appointments, notifying public hospital healthcare workers about the incoming referred patients, facilitating communication across facilities, and enhancing patient-based care.
Conclusion: A mobile health application is acceptable and feasible for following up the referred presumptive tuberculosis patients referred from private to public hospitals in southwestern Uganda. Future efforts should focus on incorporating incentives to motivate and enable sustained use among healthcare workers.
Assessment of Resources for Quality Blocklaying, Bricklaying and Concreting Trade Option in Ogun State Technical Colleges
Authors: Raji Farouk Abiodun , Yisa Mukaila Abiodun
Published: August 2022

The study assesses the resources available in Ogun State Technical Colleges for quality block-laying, bricklaying, and concreting trade possibilities. Structured questionnaires were provided to 102 respondents, including 7 teachers, 2 technicians, and 93 students from eight (8) technical colleges in Ogun State that offer block-laying, bricklaying, and concreting trades. The Cronbach Alpha technique was used to estimate reliability. The alpha coefficient obtained was 0.71. A structured questionnaire and checklist were used to obtain information on availability, adequacy, and utilization. However, percentage and mean were used to analyze data obtained on the availability, adequacy, and utilization respectively. The results show that all of the required resources are available, but to varying degrees, ranging from very high to low; 2% are very highly available, 11.5% are highly available, 36.5% are moderately available, and 50% are poorly available quality block-laying, bricklaying, and concreting (BB&C) trade option in Ogun State Technical Colleges. Furthermore, the results suggest that 84.5% of the resources necessary are insufficient, 13.5% are adequate, and 2% are highly adequate. The findings also show that just 2 of the 14 pieces of equipment are frequently used, while the remaining 12 are only occasionally used. However, 22 of the 34 tools are frequently used, while the remaining 12 are only occasionally used. The study concluded that more funds should be injected into technical colleges to enable the provision of adequate tools and equipment for the implementation of technical education programs, and that personnel in Ogun State Technical Colleges should be sensitised to the importance of utilising available tools and equipment for quality block-laying, bricklaying, and concreting (BB&C) trade options.
Detection of Salmonella spp. in eggs for human consumption from poultry farms in municipalities of Alagoas State, Brazil
Authors: Vasconcelos Artur Bibiano de , França Danilo Alves de , Ferreira Maria de Nazaré Santos , Araújo Dayane Kelly Gomes de Oliveira , Vasconcelos Catarina Bibiano de , Silva Karla Patrícia Chaves da
Published: August 2022

Salmonellosis is a disease that worries poultry farmers and can seriously impact the food safety of the population that consumes products of animal origin. The present study sought to detect the presence of Salmonella spp. in eggs intended for consumption from family poultry farms in municipalities of Alagoas State. The study was carried out from eight farms, where the sample from each farm was obtained by making pools of shell and internal contents of six randomly selected eggs. The pools were submitted to microbiological culture and the colonies were characterized and evaluated by means of laboratory tests. To this end, 50% (4/8) of the shell samples and 75% (6/8) of the internal contents of the eggs were positive for Salmonella spp. In addition, Klebsiella pneumoniae 12.5% (1/8) and Proteus spp. 25% (2/8) were found in the shell samples, and Yersinia spp. 12.5% (1/8) in the internal contents of the eggs. Salmonella spp. and other enterobacteria were confirmed to occur in eggs intended for consumption. The way the birds were raised did not seem to have a significant influence on the results obtained, and the presence of passerines on the farms may have contributed to the existence of bacteria there. Being aware of the risk to public health that some of these bacteria can present, it is necessary to take decisions that support the small producer in search of food safety for all.
Situational profile of equidae breeders in the municipality of Soure, Pará: an approach to glanders and adoption of relevant sanitary measures
Authors: Carmo Eloísa do Amparo Rodrigues do , Melo Solange de Araújo , Improta Clóvis Thadeu Rabello , Albuquerque Kelly Cristiny Gomes da Paixão , Pinho Ana Paula Vilhena Beckman , Serrão Elaine Leão Queiroz
Published: August 2022

A survey was conducted on the knowledge, attitudes, and behaviors of Equidae breeders in the municipality of Soure, Marajó Island, Pará, regarding animal health problems in the properties, especially glanders and adoption of sanitary measures that are pertinent to their combat, to elaborate on educational technical material with the appropriate methodology. The study included 50 interviewees from urban and rural areas of this municipality. Regarding data collection, structured interviews containing 22 multiple choice questions on the socioeconomic characteristics of breeders and/or owners of Equidae, breeding habits and models, and conceptions about sanitary control and their relationship with the animal health defense agency were conducted. From the qualitative analysis of data, 66% (33/50) interviewees were identified as literate, which facilitates the choice of the best language to use for communication. Regarding the choice of the best language for the transfer of information, 62% (31/50) interviewees said that a mobile phone is currently the best tool for transmitting information. Further, 40% (20/50) interviewees breed their Equidae extensively, raising an alert for epidemiological surveillance, and only 10% (5/50) interviewees turned to ADEPARÁ when the animals were sick. Based on the study results, Equidae breeders need guidance regarding the actions of the animal health defense services, and sanitary education is a fundamental measure for raising awareness and clarification of glanders to mitigate damage to public health and animal welfare, avoiding its spread in the State.
APLIKASI HOUSEKEEPING HOTEL BERBASIS WEBSITE
Authors: Natalia Deasy Chrisnia , Puspaningrum Alivia Saskia
Published: August 2022

Departemen Housekeeping merupakan salah satu bagian yang ada di dalam hotel yang menangani hal-hal yang berkaitan dengan keindahan, kerapian, kebersihan, kelengkapan, dan kesehatan seluruh kamar, juga termasuk area-area umum lainnya, dengan tujuan agar seluruh tamu maupun karyawan dapat merasa nyaman dan aman berada di dalam hotel. Departemen ini memiliki hubungan dengan seluruh departemen yang lain. Setelah melakukan observasi dan wawancara didapatkan permasalahan yaitu, koordinasi antar departemen masih dilakukan secara manual sehingga data memiliki kerentanan yang tinggi dalam terjadinya kehilangan. Berdasarkan hal tersebut, maka aplikasi housekeeping berbasis website ini dibuat untuk memudahkan Departemen Housekeeping dalam menjalankan kinerjanya serta penyaluran koordinasi terhadap departemen lain, yang dikhususkan untuk departemen front office serta departemen logistik.
Kepemimpinan Pendidikan Kepala Sekolah di Tahun Pertama Krisis Pandemi Covid-19
Authors: Andriani Dwi Esti , Annisa Ria , Rahmat Baiquni , Isbianti Pandit , Suyud Suyud , Lestari Slamet , Kristyningsih Devi Monita
Published: August 2022

This study aimed to explore principal leadership at the beginning of the Covid-19 pandemic crisis. This study employed a qualitative approach that was exploratory and naturalistic with the purpose of gaining an understanding of a phenomenon in its natural setting. Data collection was carried out by semi-structured in-depth interviews with six elementary school principals who were selected purposefully using certain criteria. The collected data were then analyzed qualitatively using grounded theory methods. The member check technique was applied to assure data credibility. The results showed that principal leadership at the beginning of Covid-19 pandemic crisis was more concerned with achieving health for the school community than academic achievement. Therefore, they provided flexibility to teachers in managing instructions, created safe communication channels among all the school members, directly monitored and evaluated online learning, empowered competent teachers to develop the ICT skills of their colleagues, and fostered collaboration with stakeholders.
Contextualization of an Introductory Physiology Course to Address Student Disengagement during Remote Learning in Aotearoa
Authors: Brown Stephen J.
Published: August 2022

Extended periods of population lockdown during the Covid-19 pandemic required many university courses to be delivered completely online, and for a student, this can lead to feelings of isolation, disconnectedness, and disengagement. This article proposes a hypothetical modification to an undergraduate course in physiology to address possible student disengagement when studying remotely. Through contextualisation, the delivery of course content is made relevant to everyday life experiences in Aotearoa (New Zealand)—this approach may improve retention of material and sustain interest in the course. Four scenarios are presented which align physiology content with information sources that present a context relevant to the lived experience in Aotearoa. Each scenario’s learning outcomes, course content, and assessment are constructively aligned, consistent with current pedagogical practices in course design. It is suggested that adopting this contextualisation approach may increase the likelihood of student course completion, reduce student attrition, and increase student engagement during periods of extended remote learning. Further, it is suggested that using contextualisation presents an opportunity to redesign a higher education course to focus more on the relevance of academic material to the real-world lived experiences of students.
An overview of a long-life battery technology: Nickel–iron
Authors: Raminosoa Andrianary Lala , Randrianandraina Hery Zo , Ramanantsoa Ravo , Rakotomalala Minoson
Published: August 2022

This survey was designed following the progress of the use of solar energy. Madagascar is one of the countries that benefit enormously from this energy. As a result, many Malagasy people use photovoltaic cells for domestic and professional applications especially those who are outside the electrified areas. However, the used batteries last only 5 years or even 10 years at most, hence the idea of updating Thomas Edison's research in 1901, a nickel–iron battery technology which is distinguished by its long lifespan of more than 25 years. It is therefore a question of determining the chemical reactions involved into the battery, its aging process, its characteristics, its advantages and disadvantages compared to the lead–acid technology. Once the theoretical studies are carried out, the study proposes an application of nickel–iron technology in a photovoltaic installation in Madagascar.
Los catálogos de autoridad de nombres personales: propósitos y metadatos
Authors: Hernández Sánchez Nallely
Published: August 2022

El presente artículo tiene como objetivo identificar el/los propósito(s) actual(es) de los catálogos de autoridad de nombres personales, a partir de los metadatos (elementos/atributos) que han sido incluidos en dichos catálogos, tras la aplicación de estándares de normalización. Para lograr este objetivo, se recurrió al análisis documental como método de investigación, de modo que se hizo una revisión y un análisis de la literatura existente en torno al control de autoridad, los catálogos de autoridad y los estándares de normalización empleados en el desarrollo de dichos catálogos. El análisis de la información localizada en la literatura se hizo bajo un enfoque cualitativo con alcance descriptivo. Se identificó que el control de autoridad sobre nombres personales y su realización mediante la aplicación de estándares como las GARE, las GARR y AACR, ha tenido y tiene un propósito organizativo, mismo que se ve reflejado en la elaboración de catálogos de autoridad. Sin embargo, con la introducción de estándares como FRAD, RDA y LRM, el propósito de dichos catálogos puso énfasis en el aspecto informativo. Es así que esta investigación sostiene que en la actualidad el propósito de los catálogos de autoridad de nombres personales, además de ser organizativo, es -o puede ser- informativo, dependiendo de los metadatos (elementos/atributos) que sean incluidos.
Reflexões multidisciplinares sobre o espectro das ontologias
Authors: Sousa Heber Tormentino de , Lima Gercina Ângela de , Araújo Webert Júnio
Published: August 2022

Introducción: La calidad de un trabajo científico puede evaluarse por el uso correcto de la terminología, por lo que es conveniente realizar investigaciones para conocer el significado en el contexto de uso, el origen y la autoría de los términos. Objetivo: En este contexto, el objetivo del artículo fue obtener una mejor clarificación terminológica del concepto “Espectro de Ontologías”. Metodología: Los procedimientos metodológicos incluyeron identificar las palabras clave, realizar investigaciones en bases de datos científicos en busca de colecciones, recopilar la producción científica que contiene las palabras clave y examinar las publicaciones para comprender la contribución de cada una al tema en análisis. Resultados: se recolectaron 353 documentos. Se investigaron citas, autoría y definiciones del concepto/término, bajo la lente de la multidisciplinariedad intrínseca al tema. Conclusión: Como se estableció el “Espectro de Ontologías” en Ciencias de la Computación (CC) con miras a analizar el potencial de los instrumentos de Organización del Conocimiento para facilitar la inferencia computacional, se concluyó que, en Biblioteconomía y Ciencias de la Información, el término equivale a “Sistema de Organización del Conocimiento” y se enfoca en la calidad del contenido, mientras que en la CC el foco está en la estructura formal. Así, el Espectro de Ontologías explica los aspectos multidisciplinarios involucrados en el proceso de Recuperación de Información.
Microbial Enhanced Oil Recovery (MEOR) Surfactant from Pseudomonas aeruginosa isolated from Automobile Garage soil.
Authors: Prasad Niraj , Dasgupta Sumita , Chakraborty Mousumi , Gupta Smita
Published: August 2022

Abstract: Microbial enhanced oil recovery (MEOR), is gaining attention today for being environmentally friendly, economically attractive, demonstrating improvement in recovery of oil entrapped in porous media. It is considered to be more efficient than other EOR methods when applied to carbonate oil reservoirs. In the current study oil degrading bacteria was isolated from soil of automobile garage. The biosurfactant producing organism was screened and characterized. 16SrRNA sequence of the most potent bacterial strain suggests it to be belonging to the genus Pseudomonas and species aeruginosa. The biosurfactant produced by the bacteria was detected as rhamnolipid with emulsification index of 69%, foaming of 57.69% and interfacial surface tension of 0.6 mN/m. The MEOR column assay revealed that the additional oil recovery for sand1 and sand2 was 62.142% and 52.173 respectively.