bluuebunny/crossref_metadata_2025 huggingface dataset:
Etnomatematika Candi Tawangalun Sidoarjo pada Materi Geomerti di Sekolah Dasar: Studi Eksplorasi
Authors: Rozzaq Goffar Ar , Yustitia Via
Published: January 2025

Candi Tawangalun arsitekturnya memuat budaya yang berbentuk materi geometri. Perlu dieksplor dan dikaji mengenai bagian-bagian candinya yang terbentuk dari beberapa bangun datar dan bangun ruang. Bangun tersebut menjadi dasar untuk memahami sifat-sifat, rumus, dan hubungan antara berbagai objek geometris. Penelitian bertujuan (1) mendeskripsikan etnomatematika yang dieksplorasi melalui Candi Tawangalun dan (2) mendeskripsikan konsep bangun datar dan bangun ruang melalui eksplorasi Candi Tawangalun. Penelitian menggunakan penelitian kualitatif dengan pendekatan etnografi. Metode dalam penelitian menggunakan metode observasi, wawancara, dan dokumentasi. Hasil penelitian (1) ditemukan bahwa Candi Tawangalun memiliki beberapa konsep matematika pada materi bangun datar dan bangun ruang. Konsep bangun datar terdapat pada Candi Tawangalun tampak depan, tampak samping kiri, tampak belakang, tampak samping kanan, pedupaan, tangga, halaman Candi Tawangalun sebelah utara, sebelah timur laut, sebelah timur, sebelah tenggara, dan sebelah selatan serta lubang Candi Tawangalun. Bangunan tersebut memiliki bentuk persegi, persegi panjang, segitiga, trapesium, dan lingkaran. Konsep bangun ruang berupa prisma trapesium pada bentuk bangunan Candi Tawangalun. Serta (2) hasil penelitian etnomatematika kemudian dikaji berdasarkan capaian pembelajaran di sekolah dasar. Adapun capaian pembelajaran yang dapat dikaitkan dengan konsep bangun datar dan bangun ruang terdapat pada kelas 2, kelas 5, dan kelas 6.
Efektivitas Pembelajaran Matematika Kelas VIII Melalui Model Auditory Intellectually Repetition Berbantuan Web
Authors: Ama Ama Noor Fikrati , Ineztasya Eka Rahmadhani  , Ririn Febriyanti  , Fatchiyah Rahman
Published: January 2025

Keefektifan sebuah pembelajaran didukung oleh peran guru dalam mengelola pembelajaran, keterlibatan siswa, dan sumber belajar/lingkungan belajar yang memadai. Penelitian ini bertujuan untuk melihat efektivitas pembelajaran matematika kelas VIII melalui model auditory intellectually repetition (AIR) berbantuan web pada materi lingkaran. Penelitian dilaksanakan di SMP Negeri 5 Jombang pada semester genap tahun 2022/2023 dengan menggunakan pendekatan kuantitatif. Sampel penelitian ini adalah siswa kelas VIII H sebagai kelas eksperimen yang diterapkan model AIR berbantuan web, dan siswa kelas VIII G sebagai kelas kontrol yang diterapkan model kooperatif tipe STAD. Pengumpulan data dilakukan melalui lembar pengamatan aktivitas siswa, dan lembar tes hasil belajar. Data hasil pengamatan dianalisis menggunakan rumus persentase, sedangkan data hasil tes dianalisis menggunakan uji-t. Indikator efektivitas pembelajaran dalam penelitian ini ada 2, yaitu: (1) aktivitas belajar siswa pada setiap aspeknya minimal 75%, dan (2) hasil belajar siswa pada kelas eksperimen lebih baik daripada kelas kontrol. Hasil penelitian menunjukkan bahwa hanya aktivitas siswa di kelas eksperimen yang setiap aspeknya mencapai ≥ 75%, dan hasil belajar siswa pada kelas eksperimen lebih baik daripada hasil belajar siswa di kelas kontrol. Sehingga dapat disimpulkan bahwa model auditory intellectually repetition berbantuan web efektif diterapkan pada pembelajaran matematika khususnya materi lingkaran di SMP Negeri 5 Jombang.
Development and Evaluation of in situ eye gel for delivery of gatifloxacin and betamethasone sodium phosphate
Authors: Fatima Mustafa Ali  , Athmar Dhahir Habeeb Al-Shohani  , Asma Buanz
Published: January 2025

التحدي الرئيسي الذي يواجه العلماء في مجال النقل البصري هو التخلص السريع من المواد الموجودة قبل القرنية في العديد من التطبيقات، وخاصة في المضادات الحيوية. فقط 5% من قطرات العين تدخل إلى القرنية.
تم تصميم هذه التقنية لحل المشكلة عن طريق زيادة وقت الاتصال بالقرنية. بمجرد تطبيقه على العين، يتحول المحلول على الفور إلى مادة هلامية. الهدف من هذه الدراسة هو تحضير قطرة عين موضعية باستخدام بوليمر بولوكسامير 407 وصمغ جيلان حساس للأيونات ودراسة تأثير إضافة بوليمرات مخاطية لاصقة ميثيل السليلوز (MC) لتطوير عيون فعالة وطويلة المفعول. أنظمة توصيل الأدوية المضادة للبكتيريا والمضادة للالتهابات ) GTNوBSP (لعلاج التهاب الملتحمة الحاد.
تم تحضير المستحضرات التي تحتوي على 17% بولوكسامير 407 و 0.5% صمغ جيلان بنسب مختلفة من MC ومقارنتها فيما يتعلق بدرجة حرارة التبلور، وقدرة التبلور، وزمن التبلور، ودراسة التحرر والالتصاق المخاطي. أدت زيادة تركيز MC إلى تعزيز جميع الخواص الفيزيائية لجيل صمغ البولوكسامير جيلان. الصيغة المثالية (F3) التي تحتوي على 0.3% MC كان لها 5 ثواني من وقت التبلور عند 31 درجة مئوية وبقيت على شكل هلام لمدة 24 ساعة. تم تمديد إطلاق كلا العقارين ولم يلاحظ أي تهيج في عين الأرنب عند اختباره على الحيوانات .
من خلال تحسين فترة الإقامة قبل القرنية والتوافر البيولوجي للعين نتيجة للتناول الأقل تكرارًا، قد يُنظر إلى تركيبة الجل الجديدة في الموقع كبديل متفوق لقطرات العين التقليدية من جاتيفلوكساسين وبيتاميثازون لعلاج التهابات العين.
AI-Enhanced Stock Market Prediction: Evaluating Machine Learning Models for Financial Forecasting in the USA
Authors: Sizan Mir Mohtasam Hossain , Das Bimol Chandra , Shawon Reza E Rabbi , Rana MD. Sohel , Montaser Md Abdullah Al , Chouksey Anchala , Pant Laxmi
Published: January 2025

In the USA, one of the world's largest and most liquid financial markets, the ability to anticipate market trends has deep economic implications. Precise stock market forecasting is highly instrumental for investors and analysts in making better asset allocation decisions, managing risks, and setting investment strategies. This research aimed to analyze the efficiency of some machine learning models in stock market forecast evaluation. This research project concentrated on stock market data from the USA, exploring historical price patterns, trading volumes, and relevant economic indicators to assess the performance of various machine learning models. The dataset used for this research work about predicting stock market trends is an exhaustive collection of historical stock prices, some fundamental financial indicators, and relevant news about the market, gathered from various dependable sources. Historical stock prices are retrieved from financial market databases like Yahoo Finance and Google Finance. These sources have daily records of open, high, low, and close prices, and trading volumes for thousands of publicly traded companies for extended periods, normally running into several years. The analyst selected several strategic models, namely, Random Forest, Gradient Boosting, and Logistic regression. Logistic Regression outperformed the other two models with relatively higher accuracy, while the others are just a little below. The findings of this study have implications well beyond academic curiosity into investment strategies and financial analysis. By leveraging the strengths of the best models, investors can create better-informed trading strategies. These models can also include predictive insights that give a serious edge to the risk management strategy in an investment portfolio. By using the predictive power of models like Random Forest, investors can foresee market fluctuations and adjust their portfolios to reduce potential losses.
Co-existence of Sickle Hepatopathy with Autoimmune Hepatitis: More than a Coincidence – A Case Report
Authors: Alhashmi Majed , Mohamed Ali , AbuAlsaud Baha , Alfaraj Rayan , Khamis Mohamed , AlAlawi Yaqeen , Maki Hussain , Alaradi Husain , Alghadhban Ali , Alkhalifa Zahra
Published: January 2025

Sickle Cell Hepatopathy is a multifactorial liver disease that can have an impact on half of patients with Sickle Cell Disease (SCD), with a cryptic and puzzling connection appearing to be associating Sickle Cell Disease (SCD) with Autoimmune Hepatitis (AIH), repeatedly yielding diagnostic neglect and delay, bringing about disastrous consequences. This case introduces to you a 41-year-old single Saudi male known to have Sickle Cell Disease (SCD), who was accidentally diagnosed with advanced liver cirrhosis by pure chance during laparoscopic cholecystectomy. This study will draw attention to the diagnostic challenges concerning the overlap between sickle hepatopathy and Autoimmune Hepatitis (AIH), while sharing intriguing histopathological findings. Suggested theories that point out the unique relationship between the two entities are offered for a greater understanding of the complex pathophysiological process. Literature gaps are also discussed, owing to the absence of an agreed-upon recommended and safe therapeutic option for Autoimmune Hepatitis (AIH) in the context of Sickle Cell Disease (SCD) specifically, which forced starting the patient on the second line of treatment – Mycophenolate Mofetil (MMF). We learn from this case the value of early screening for liver disease in patients with Sickle Cell Disease (SCD) as well as the essential need for tailoring the therapeutic plan according to the type of patients when Autoimmune Hepatitis (AIH) is present.
Функціональна модель системи управління бездротовими сенсорними мережами військового призначення
Authors: Жук Олександр , Машталір Вадим , Грозовський Роман , Чекан Андрій
Published: January 2025

Відмінною рисою розвитку сучасної системи зв’язку і автоматизації управління Збройних Сил України під час відбиття збройної агресії, є тенденція до переоснащення та модернізації військ (сил) новітніми високотехнологічними засобами зв’язку, зокрема, бездротовими системами. Складовими таких систем можуть бути бездротові сенсорні мережі, що здатні забезпечувати моніторинг, збирання даних та передачу інформації. Проте складність, обмежені ресурси, різні типи трафіка, ненадійність і обмеженість ресурсу та необхідність динамічного налаштування під змінні умови потребують створення ефективної моделі управління з підтримкою безпеки на потрібному рівні. Метою статті є удосконалення функціональної моделі системи управління бездротовими сенсорними мережами для забезпечення оптимального використання ресурсів, адаптивності до змін умов експлуатації, високої надійності й безпеки функціонування. Удосконалення зазначеної моделі здійснюється завдяки додавання підсистеми управління безпекою до складу системи оперативного управління мережею. Удосконалена модель передбачає структуризацію системи на рівні, зокрема: рівень сенсорів, рівень обробки даних та рівень передачі інформації, й складається з підсистем. Визначено такі ключові компоненти та процеси, як управління енергоспоживанням, балансування навантаження, адаптивна маршрутизація, забезпечення безпеки. Модель підтримує гнучкість у налаштуванні мережі, що дає змогу адаптуватися до змін у структурі чи умовах експлуатації. Відмінність наведеної моделі від існуючих, що визначає її новизну зводиться до застосування нової множини метрик пошуку маршруту. До цих метрик належать: тип переданого трафіка, залишкова ємність батарей вузлів, енергія, необхідна для передачі та обмеження на пропускну спроможність радіоканалів. Крім того, модель використовує вдосконалені правила вибору маршруту, що дає змогу зменшити витрати енергії, а тим самим підвищити тривалість функціонування бездротової сенсорної мережі. Впровадження функціональної моделі системи управління бездротовими сенсорними мережами дасть змогу створити адаптивну розподілену архітектуру побудови безпровідних сенсорних мереж із можливістю самоорганізації мережі та підвищити ефективність функціонування безпровідної сенсорної мережі в цілому шляхом збільшення тривалості функціонування мережі за умови виконання вимог до інформаційного обміну. У перспективі дослідження передбачає інтеграцію запропонованої моделі з хмарними платформами для забезпечення масштабованості та підвищення обчислювальної ефективності.
The analysis of external and internal threats of electronic ticket functioning at entertainment events
Authors: Biehun Anatolii , Osypova Olha , Plakhtii Maksym , Urdenko Oleksandr
Published: January 2025

E-ticketing activities are fully inherent in both traditional business threats and e-commerce threats posed by e-business technologies and the widespread use of computer and telecommunications technology. Threats in the sale of electronic tickets arise at almost all stages of activity and affect the interests of both sellers and buyers. Therefore, the need for comprehensive measures to identify and monitor threats is obvious to companies engaged in the sale of electronic tickets. The solution to the problem of counteracting the security threats of enterprises engaged in the sale of electronic tickets to entertainment events, primarily related to addressing the protection of information technology used in it, ie to ensure information security. The classification of threats to information security is an important step in assessing the security of information systems and the development of measures to ensure information security of the enterprise. In this study, which has a scientific and methodological nature, classified and systematized the threats that accompany the activities in the field of electronic tickets for entertainment events. The classification of threats to information security of enterprises engaged in the sale of electronic tickets to entertainment events is carried out on the basis of a combination of the following criteria: 1. The origin of the threat: external and internal threats.
2. Sources of threats: threats caused by human activities; threats, the source of which are software and hardware; threats posed by the natural environment.
3. Intention to realize a security threat: intentional and unintentional actions of the violator.
The results of the classification of information security threats can be further used in the process of conducting an information security audit of the enterprise.
Specific software solutions for conducting an information security audit of the enterprise are also considered.
The need for Gender Equality Plans and Gender Budgeting in Albanian Higher Education – Insights from the University of Tirana in the context of sustainable institutional change
Authors: Leskaj Etleva , Gjika Lindita
Published: January 2025

Promoting gender equality and empowering women and girls are pivotal objectives for sustainable development, demanding coordinated efforts from nations and institutions worldwide, including the higher education sector. The systemic disadvantage faced by women within Albania’s higher education system underscores the crucial role of gender equality plans and gender budgeting as strategic instruments for fostering sustainable institutional change. This research identifies various aspects of gender inequality in Albania’s higher education sector through secondary research using government statistics and published datasets. Additionally, through a case study approach and survey data, it conducts a comprehensive analysis of the gender context at the University of Tirana, recommending the development of gender budgeting and gender equality plans within the institution. The research aims to pinpoint gender-related issues and propose gender equality plans to address them. Drawing insights from the University of Tirana case, the authors advocate for the adoption of these gender equality plans by other higher education institutions in Albania. This initiative seeks to progressively tackle gender inequalities and integrate sustainable practices into the planning processes of these institutions. Gender budgeting and gender plans should form integral components of the decision-making process in universities. By fostering policies and regulations that support gender equality throughout the institution, they can better respond to the diverse needs of all students, professors, and academic staff.
Characteristics and Expectations of Low-Paid Workers in the Care Services Sector in Poland
Authors: Grzesiak Kamila
Published: January 2025

The article analyses the specific nature of work among elderly caregivers in Poland as a low-paid group and identifies these employees’ expectations towards employers. In the context of an aging society, which increases the demand for caregiving services, the low level of compensation and social prestige associated with this profession poses a significant challenge that may negatively impact employees’ engagement and job satisfaction. The study is based on literature review, a survey method directed at caregiving sector employees and statistical data analysis, which enabled a comprehensive identification of factors affecting their motivation and expectations. The results indicate the need to implement motivational strategies aimed at improving working conditions and enhancing job satisfaction among caregivers. Applying such solutions may contribute to increased productivity and reduced employee turnover in this professional group.
Desempeño de estudiantes de bachillerato técnico en formación en centros de trabajos: una mirada crítica, propositiva
Authors: Mejía Flores Mayra Katerine , Guzmán Hernández Ramón
Published: January 2025

Introducción: La formación en centros de trabajo forman parte primordial en el proceso de aprendizaje de los estudiantes de bachillerato técnico. Objetivo: Analizar las causas que influyen al bajo desempeño de los estudiantes de bachillerato técnico durante su formación en centros de trabajo, con el fin de identificar aspectos de mejora y proponer al menos una estrategia efectiva para optimizar la formación práctica. Metodología: Se utilizó un tipo de enfoque mixto, que combina los métodos científicos cualitativo y cuantitativo, se usó también un diseño de tipo descriptivo y exploratorio, en el que participaron 36 estudiantes, 13 docentes y 7 supervisores. Resultados: Los resultados que se obtuvieron arrojaron que la comunicación, el ambiente e infraestructura y el conocimiento y la práctica son causas que interviene en el proceso de FCT. Los resultados en docentes mostraron que el desempeño de los estudiantes es bueno en el proceso de FCP. Finalmente, los resultados en supervisores mostraron la importancia de la retroalimentación regular en los estudiantes. Conclusión: Se concluyó que la comunicación, el ambiente y la infraestructura y los conocimientos previos son causas que interviene de manera directa en el desempeño y aplicación de las capacidades obtenidas durante el proceso de formación en centros de trabajo para su correcta aplicación en el campo laboral, sin embargo, en esta investigación los resultados obtenidos fueron positivos con respecto al desempeño de los estudiantes. Área de estudio general: educación. Área de estudio específica: formación técnica. Tipo de estudio:  Artículos originales.
Medical and hygienic means of prevention of generalized periodontal diseases in patients with manifestations of anxiety
Authors:   Bogomolets National Medical University, Kyiv, Ukraine, Horodnov Y.
Published: January 2025

The purpose of the study: to investigate and substantiate the choice of medical and hygienic means (toothpastes) for the prevention
of dystrophic-inflammatory periodontal diseases.
Research materials and methods. The object of the study was 157 patients with generalized periodontitis associated with manifestations
of anxiety, aged 35–55 years, the gender composition of patients—men (28.7%), women (71.3%).
Research results. It was established that during the clinical examination of the oral cavity using the Green-Vermillion hygiene index,
RI and RMA, the indicators had a satisfactory, unsatisfactory and poor state of hygiene. For the purpose of treatment and prevention, it
was suggested to use toothpastes. Parodontax Complex Protection paste was chosen by 30 women and 11 men who were included in the GP-“P” group; Lacalut fitoformula paste was used by 35 women and 8 men, whom we included in the GP-“L” group; 31 women and
12 men were identified from Colgate Total 12 Medicinal Herbs and were included in the GP-“C” group. Preventive measures of the oral
cavity with toothpastes lasted 6 weeks. After that, the effectiveness of Parodontax Complex Protection, Lacalut fitoformula, and Colgate
Total 12 Medicinal Herbs pastes were determined. Also, using a questionnaire, the use of toothbrushes and mouth rinses was investigated.
Conclusion. It was found that the studied toothpastes Parodontax Complex Protection, Colgate Total 12 Medicinal herbs, and Lacalut
fitoformula showed high efficiency of use, which is proven by the results of dynamics and explained by the composition of plant components.
According to our research, the Parodontax Complex Protection toothpaste turned out to be a more effective preventive measure. Based
on this, it is advisable to recommend it in the maintenance phase of complex treatment of inflammatory periodontal diseases in patients
associated with manifestations of anxiety.
Keywords: generalized periodontitis, treatment, prevention, toothpastes.
Incidental finding of mixed hemoglobinopathy in pregnant woman - Case report
Authors: Lopez Muñoz Diego Fernando , Gutierrez-Bonilla Karol Vanessa , Castaño-Ospina Juan Camilo , Velandia-Mosquera Cristhian Camilo , Taborda-Ipus Valentina , Montezuma-Sanchez Caterine Eliseth , Galeano-Ruiz Juan Andrés
Published: January 2025

Microcytic and hypochromic anemic syndromes, beta-thalassemia type are usually underdiagnosed. Due to the similarity of clinical manifestations, the need for complementary studies, and the lack of clinical suspicion. This hinders their timely intervention. This study aimed to show a clinical case of an incidental finding of mixed hemoglobinopathy in a pregnant woman. we present the case of a 25-year-old primigravida patient hospitalized in the context of sepsis of urinary origin, associated with encapsulated bacteria. The hemogram reports low hemoglobin and refractoriness to iron treatment. Ferrokinetic studies were normal, the blood smear revealed a varied poikilocytosis, it was suggested to perform hemoglobin electrophoresis, which reported a mixed hemoglobinopathy as an incidental finding.
Prevalencia y diagnóstico de Chlamydia trachomatis en mujeres en edad fértil. Una revisión sistemática
Authors: Lopez Muñoz Diego Fernando , Martinez-Marulanda Emanuel Horacio , Velandia-Mosquera Cristhian Camilo , Valencia-Quintero Yury Lorena , Montezuma-Sanchez Caterine Eliseth , Ardila-Lozano Valentina , Romero-Escobar Ana Maria
Published: January 2025

A nivel mundial las enfermedades de transmisión sexual (ETS) son un problema que enfrenta la salud publica involucrando miles de personas durante cada año, entre las mas destacadas se encuentra la Chlamydia trachomatis (Ct), la cual es la ETS bacteriana que más registrada en diferentes países alrededor del mundo. Este es un microorganismo intracelular obligado que afecta células en el tracto genital. El objeto fue construir una revisión de la literatura sobre el tema de prevalencia y el diagnostico de la Ct en las mujeres en edad fértil. La metodología se enmarca como una revisión sistemática en la cual se tomaron bases especializadas tales como ScienceDirect, Pubmed, Scopus, Web of Science, Lilacs y Scielo, con un horizonte desde 2019 hasta 2024 creando una fórmula de búsqueda con boléanos y palabras clave (mujeres en edad fértil, prevalencia, epidemiologia y diagnostico) Además se utilizó Guías como: Prisma y STROBE respaldando la veracidad de la información para el presente artículo. Resultado: se eligieron 7 registros los cuales cuentan con información sobre el tema en cuanto a prevalencia y el diagnóstico para Ct. Destacando países como Chile, Francia, Kenia, Irán y Reino Unido también destacando métodos como la PCR, NAAT, RDT Basado en Inmunoensayo, Serología, Autotoma y Pruebas Urinarias con PCR Combinada. Conclusiones: la prevalencia de Ct varía según el contexto geográfico además del contexto poblacional, es importante subrayar las necesidades en la implantación de nuevos planes de acción de manera integral y multidisciplinar desde la Salud Pública.
Práticas pedagógicas em tutoria no Programa Escola da Terra: Experiência na Educação Contextualizada para a convivência com o Semiárido
Authors: Almeida Leandro de Sousa , Alencar Alisson Clauber Mendes de
Published: January 2025

O Programa Escola da Terra é uma das ações do Programa Nacional de Educação do Campo (PRONACAMPO). Programa lançado pelo Governo Federal em 20 de março de 2012, Portaria nº 86 de 02 de fevereiro de 2013, visando promover uma educação que atenda à realidade dos povos do campo e quilombolas. Promove acesso e melhoria das condições de aprendizagem, articulando o trabalho docente à realidade das comunidades. Oferece formação continuada para professores, focando em metodologias adequadas ao cotidiano dos sujeitos que vivificam o ambiente escolar e o território campesino. O objetivo do presente artigo é apresentar um relato de experiência na Educação Contextualizada para a convivência com o Semiárido. Assim sendo, tem-se no trabalho da tutoria um suporte a mais para a formação crítica dos professores, integrando teoria e prática à realidade social. Entre as atividades estão: visitas às escolas, reuniões de colegiado e oficinas educativas, com o objetivo de fortalecer a educação contextualizada e a convivência com o Semiárido. Trouxemos enquanto intercessores teóricos para a fundamentação deste estudo, Freire, Martins, Reis e Silva. Percebeu-se durante o percurso formativo que a tutoria desempenha um papel fundamental na consolidação da formação continuada dos estudantes no ambiente acadêmico.
Evaluating the Nutritive Value and Quality of Fodder Pea (Pisum arvense L.) Silage Added with Varying Rates of Barley (Hordeum vulgare L.) and Wheat (Triticum aestivum L. Em Thell) Cracks
Authors: Ateş Ertan , Tenikecier Hazım Serkan
Published: January 2025

Silage represents the most effective solution for addressing the deficit in quality, abundance and cost-effectiveness of roughage. The main purpose of silage production is to store fresh herbage material with high nutritional value with minimum nutrient loss. For fodder and silage production, fodder pea is grown in mixtures with cereals in different ratios, but also for the silage from the pure fodder pea using additives. Molasses and crashed cereal grains or cereal can be added to silage material in order to increase its carbohydrate content. The research was conducted to determine nutritive value and silage quality of barley and wheat cracks added at different ratios to fodder pea silage in complete randomized split-plot design with four replications. 100 g withered fodder pea sample without additives and 100 g withered fodder pea sample with 3 g, 6 g, 9 g and 12 g cracked barley were vacuumed in to the 20x26 cm plastic bags and were stored in a dark environment for a period of 45 days to facilitate fermentation at ambient temperatures ranging from 15 to 28°C. Crude protein (%), crude ash (%), dry matter (%), digestible dry matter (DDM, %), dry matter intake (DMI, %), ADF (%), NDF (%), P (%), K (%), Ca (%), Mg (%), total digestible nutrients (TDN), Nel, NEm, Neg, pH, Fleig Score and RFV of pure fodder pea and cracked barley and wheat added silages were determined. According to results, fodder peas, which have a high protein and low carbohydrate content, be ensiled by the addition of high-carbohydrate wheat and barley cracks in order to obtain a quality silage. For this purpose, it is suggested to add at least 6% wheat cracks or 9% barley cracks to fodder pea silage.
Effect of Melatonin Treatment on Reproductive Hormones and Sexual Behaviors in Sheep
Authors: Öztürk Nesrin , Tölü Cemil
Published: January 2025

In seasonal oestrus animals such as sheep, out-off-season lambing practices and synchronization of oestrus are important in terms of herd management and farm economics. The present study aimed to determine the effects of melatonin implants administered before the breeding season on melatonin, estrogen, progesterone hormone concentrations, and sexual behavior in Tahirova sheep. The study was conducted on 60 Tahirova dairy ewes, aged 1-4 years, and 6 head rams, aged 1-2 years. On June 26, melatonin implants were administered to half of the ewes (18 mg dose/ewe) and rams (54 mg dose/ram). Fifteen days after the implantation of melatonin, all the ewes (530 g/ewe) and rams (660 g/ram) were given supplemental feeding (flushing) with grain feed for a period of 60 days. On August 1, the ewes exhibiting signs of estrus following the introduction of a ram were relocated to individual paddocks, where mating was conducted using the hand-mating method. The frequency of sniffing, touching the ram's scrotum, turning the ram, head-turning, and tail wagging was recorded during the hand-mating procedure. Additionally, the sexual behaviors exhibited by the ram were documented. Furthermore, an investigation was conducted to ascertain whether an interaction occurred within the first minute. The intervals, sexual interaction rate of the ewe, total frequency of sexual interaction, time per sexual interaction, and total sexual interaction time were observed. Blood samples were collected regularly on the initial day, the 21st day, the 42nd day, the 63rd day, the 94th day, and the 129th day for subsequent hormone analysis. Hormonal analyses were conducted using the ELISA method on blood serum samples. The melatonin hormone concentration was observed to be higher in the treatment (MT) group than in the control (C) group on the 63rd day (P=0.0476). The sexual interaction rate of the MT group was found to increase significantly in comparison to the C group (P=0.0045). Additionally, the gestation rate was shorter in the MT group than in the C group (P≤0.05). It can thus be concluded that the melatonin implant, when applied before the breeding season, significantly increases melatonin hormone concentrations on the 63rd day and significantly shortens the periods of gestation in Tahirova dairy sheep.
Sosialisai Kesadaran Terkait Ketertiban Masyarakat di Pulau Soop
Authors: Akmal Ridwan  , Edwar Rizka Cintya , Digor Mufti  , Munifa  , Indra Eka Wardana Toii
Published: January 2025

Kegiatan kuliah kerja nyata (KKN) Di laksanakan pada Hari selasa 6 agustus 2024 bertempat di smp negeri 9 kota sorong kelurahan soop. Metode yang di gunakan dalam kegiatan ini adalah sosialisasi kesadaran ketertiban masyarakat pulau soop. Kesadaran yang di harapkan dapat melahirkan kertiban umum demi menjaga keamanan dan kenyamanan dalam lingkungan masyarakat itu sendiri,ini juga dapat di artikan sebagai prinsip dasar untuk menjaga kehidupan berdampingan yang damai. Sebab kita ketahui bersama akhir-akhir ini tindak kejahatan cukup marak terjadi, maka lewat sosialisasi ini kami berharap ada perubahan sosial di masyarakat kelurahan soop terkait ketertiban dalam bermasyarakat.
Pemertahanan Vitalitas Bahasa Daerah dalam Masyarakat Multietnis melalui Pendokumentasian Pemilihan Bahasa Siswa Sekolah Dasar di Kota Sorong Papua Barat Daya
Authors: Taryono Mohamad Rizal , Redita Putri Intan Elfiti  , Yuliana Pakpahan  , Wulanda Tambunan  , Nur Afifa Alfina Ramadhani  , Rahmalia Khairunissa Kurnia  , Catur Navillah Puput Andhita K  , Khoirul Nissa  , Abu Sofyan  , Kamaluddin
Published: January 2025

Kegiatan pengabdian kepada masyarakat (PkM) ini bertujuan untuk mengidentifikasi keberagaman etnis, bahasa daerah, dan pola pemilihan bahasa siswa SD dalam ranah keluarga  di Kota Sorong, Papua Barat Daya. Metode yang digunakan adalah survei, kuesioner, dan wawancara pada responden yang terdiri atas siswa-siswi SD kelas 4, 5, dan 6 dari SD Negeri 2 Sorong, SD Muhammadiyah 1 Sorong, dan SD Negeri 27 Sorong. Simpulan kegiatan PkM ini adalah dari 33 etnis yang ditemukan BI menjadi pilihan paling tinggi sebagai B1. Pola pemilihan bahasa siswa SD dalam ranah keluarga menunjukkan bahwa BI dan BC sebagai bahasa yang sering digunakan siswa SD di rumah. Fenomena ini mengindikasikan bahwa masih banyak sikap orang tua yang meskipun berasal dari berbagai etnis di seluruh Indonesia tetapi kurang peduli mengajarkan bahasa daerah etnisnya sendiri dan tidak mewariskannya kepada anak-anaknya sejak dini. Kegiatan PkM ini berkontribusi nyata terhadap upaya revitalisasi bahasa daerah di Papua Barat Daya, dengan fokus pada peningkatan kesadaran dan praktik berbahasa daerah yang mendukung keberlanjutan kekayaan budaya lokal. Upaya ini bukan hanya tentang mempertahankan bahasa daerah, melainkan juga mempromosikan harmoni multietnis di masyarakat Kota Sorong yang multietnis
PKM “Pengenalan dan Pemahaman Ekosistem Padang Lamun Bagi Generasi Muda Papua”
Authors: Ratna  , Hardianti Fatimah , Kalidi Neneng S. , J. Syarif  , A.M. Suruwaky  , Fahrizal Ahmad , M. S. Rumwokas  , E. Loupatty  , Sufardin  , H. Abuhaer  , K. Gutajala  , F. Mahad  , R. M. Linta
Published: January 2025

Ekosistem padang lamun memiliki peran penting dalam menjaga keseimbangan ekosistem pesisir dan laut, selain itu padang lamun juga berfungsi sebagai habitat bagi spesies laut, mendukung keanekaragaman hayati, serta memberikan manfaat ekonomi dan sosial bagi masyarakat pesisir. Namun, ekosistem ini menghadapi ancaman serius akibat aktivitas manusia. Kegiatan Pengabdian kepada Masyarakat (PKM) ini bertujuan meningkatkan pemahaman generasi muda Papua tentang ekosistem lamun melalui pendidikan lingkungan berbasis ceramah dan diskusi interaktif. Hasil kegiatan menunjukan adanya peningkatan pemahaman siswa sebesar 20% berdasarkan perbandingan nilai pre-test dan post-test. Dengan adanya kegiatan ini, generasi muda diharapkan mampu menjadi agen perubahan yang berperan dalam pelestarian ekosistem pesisir.
Resource use efficiency in milk production in different dairy-integrated farming systems in Terai Region of West Bengal
Authors: Patowary Snigdha , Malhotra Ravinder , Chaudhary Udita
Published: January 2025

The study was undertaken in the Terai region of West Bengal with the objective to assess the resource use efficiency in milk production in different dairy-integrated farming systems. The study covered a total of 180 dairy farmers from different farming systems. The results revealed that milk production in Dairy (D), Dairy + Crop + Goat (D + C + G), Dairy + Crop +Mushroom (D + C + M) and Dairy + Crop + Fishery (D + C + F)farming systems could be increased by feeding more amount of green fodder. Similarly, dry fodder had a positive effect on milk production in Dairy + Crop (D + C), Dairy + Crop + Goat (D + C +G) and Dairy + Crop + Poultry (D + C + P) farming system whereas in Dairy (D) farming system it had a negative impact on milk production. The study also revealed that green fodder was under-utilised and concentrate was over-utilised in Dairy + Crop +Mushroom (D + C + M) farming system. In Dairy + Crop + Fishery(D + C + F) farming system concentrate was over-utilised. In overall farming system, concentrate was over-utilised in indigenous cattle in the study area, resulting in a higher per litre cost of milk production.
Effect of fat on quality characteristics of whey obtained from manufacture of Ricotta cheese
Authors: Gautam Avinash Chandra , Goel Nitika , Veena N , Singh P K , Kumar S Siva
Published: January 2025

The Ricotta cheese whey (RCW) is obtained during the manufacturing of Ricotta cheese as by product. It is highly nutritious and can be utilized in the manufacture of whey-based beverages. In the present study, RCW was analyzed for its sensory and physico-chemical properties obtained during the manufacture of Ricotta cheese from mixture of Mozzarella cheese whey and milk (80:20) with different fat levels (0.1%, 1.5%, 3.0%and 4.5% in milk). The results indicated that an increase in the fat content of milk used in the manufacturing of Ricotta cheese has a significant effect on the composition of RCW. The fat content of RCW increased with the increase in the fat content of milk used in the manufacture of Ricotta. The protein content was reported to be highest in the RCW prepared from milk with no-fat. The L* value of the sample increased while a* and b* values of the sample decreased with increase in the fat content of RCW. Sensory results revealed that RCW with higher fat content showed the highest acceptability as compared with the other samples.
Could adjuvants serve as an agroecological tool?
Authors: Brankov Milan , Simić Milena , Vukadinović Jelena , Zarić Miloš , Tataridas Alexandros , Božinović Sofija , Dragičević Vesna
Published: January 2025

Adjuvants are agrochemicals or natural substances, commonly mixed with pesticides to increase their efficacy or reduce off-target movement by modifying the physical properties of the spray solution, such as surface tension, droplet size, and spreadability, which ultimately improve pesticide adhesion and coverage on target surfaces. Adjuvant use across Europe remains less widespread compared to regions like the USA, where adjuvants are often recommended or required with certain herbicide applications. This paper highlights the potential benefits of incorporating adjuvants with herbicides in weed control, particularly as a strategy to reduce overall herbicide use. Findings from dose-response research on available adjuvants suggest they may enable the application of lower herbicide rates than typically recommended, without sacrificing effectiveness, thereby contributing to the goal of reducing herbicide use by 50% by 2030 in Europe. Furthermore, literature findings indicate that adjuvants significantly improve weed control by enhancing the performance of active ingredients, with efficacy increases of up to 50% compared to using herbicides alone. The integration of adjuvants into herbicide tank mixtures offers considerable promise, especially for managing herbicide-resistant weeds and achieving effective weed control.
Conduction system pacing using electro-anatomical mapping-guided system vs. fluoroscopy: a systematic review, meta-analysis and economic evaluation
Authors: León-Salas Beatriz , Infante-Ventura Diego , Hernández-Yumar Aránzazu , Linertová Renata , Herrera-Ramos Estefanía , Torres-Castaño Alezandra , González-Pacheco Himar , Abt-Sacks Analía , García-García Javier , Quirós-López Raúl , Trujillo-Martín María M.
Published: January 2025

Introduction

Electro-anatomical mapping (EAM) system has been shown as an alternative procedure to fluoroscopy for conduction system pacing (CSP) in patients with severe bradyarrhythmia, however its beneficial and harmful effects has not been assessed in a systematic review (SR). We sought to assess their safety, effectiveness and cost-effectiveness.

Methods

A SR of the available scientific literature was conducted on the safety, effectiveness, and cost-effectiveness of CSP using EAM system versus fluoroscopy in patients with severe bradyarrhythmia. A partial economic evaluation was carried out to compare the costs of both strategies from the perspective of the Spanish National Health System. A budget impact analysis was also conducted with a five-year horizon.

Results

Seven comparative observational studies (N = 231), analyzing the use of EAM versus fluoroscopy were selected. Statistically significant differences were observed in total fluoroscopy time: −9.87 minutes (95%CI:−14.20, −5.53, p < 0.01; I2 = 95%; k = 7; n = 231); His-lead fluoroscopic time: −8.08 minutes (95%CI:−10.36, −5.81, p < 0.01; I2 = 0%; k = 2; n = 50); and His-lead radiation dose: −17.21 mGy (95%CI:−24.08, −10.34, p < 0.01; k = 1; n = 20). No differences in total fluoroscopy dose, successful procedure or safety were found. The use of EAM represents an increase of EUR 1397.81 per patient and a net budget impact of EUR 1.63 million.

Discussion

EAM is a valuable alternative for patients who should not be exposed to ionizing radiation with similar effectiveness and safety than fluoroscopy. However, the inclusion of EAM systems, for the indication under study, in routine clinical practice would mean an increase in costs for the Spanish National Health System.

Systematic Review Registration

https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=421072, identifier (CRD42023421072).
Associations between serum total bilirubin and overactive bladder from the National Health and Nutrition Examination Survey
Authors: Jiang Bo , Ling Cunbao , Dong Binbin , Lu Xiaoming , Liu Yadong
Published: January 2025

Background

The relationship between serum total bilirubin (STB) concentrations and the risk of overactive bladder (OAB) remains uncertain. This study aims to explore the potential connection between STB and OAB.

Method

We utilized data from the National Health and Nutrition Examination Survey (NHANES) database for the years 2001-2020. Weighted multivariate logistic regression and restricted cubic spline (RCS) analysis assessed the relationship between STB and OAB. Interaction analyses on subgroups were performed to validate the findings.

Results

The study included 28,958 participants, with 5,313 identified as having OAB. The results from the fully adjusted models revealed an odds ratio (OR) of 0.98 (95% CI: 0.97, 0.99) and a statistically significant P value of less than 0.001 for the relationship between STB and OAB. Notably, individuals in the second and third tertiles exhibited significant differences compared to those in the lowest STB tertile, with respective odds ratios (P values) of 0.88 (0.04) and 0.80 (<0.001). RCS analysis indicated a non-linear association between STB and OAB (P for nonlinearity = 0.042), with an inflection point at 16.8 μmol/L. The association between STB and OAB exhibited consistency across various subgroups, except for stratification by age and diabetes status(P for interaction = 0.002 and 0.004, respectively), indicating a stronger correlation in individuals younger than 60 years or those without diabetes.

Conclusion

These findings suggest an inverse association between STB concentrations below 16.8 μmol/L and the incidence of OAB. Bilirubin could potentially serve as an intervention or risk assessment tool for OAB in future studies.
Causal association between matrix metalloproteinases and diabetic neuropathy: a two-sample Mendelian randomization study
Authors: Bai Chao , Yang Wenwen , Qi Guangwei , Yang Liuyu , Wu Qingrui , Peng Jieguang , Wang Ning , Liu Tao
Published: January 2025

Objective

Diabetic neuropathy (DN), a common and debilitating complication of diabetes, significantly impairs the quality of life of affected individuals. While multiple studies have indicated changes in the expression of specific matrix metalloproteinases (MMPs) in patients with DN, and basic research has reported the impact of MMPs on DN, there is a lack of systematic research and the causal relationship remains unclear. The objective of this research is to investigate the casual relationship between MMPs and DN through two-sample Mendelian randomization (MR).

Methods

Data for this investigation were derived from genome-wide association studies (GWAS) of MMPs and DN. For the analysis using two-sample MR, methods such as inverse variance weighted (IVW), weighted median, weighted mode, and MR-Egger were utilized, with IVW serving as the primary measure for determining causative impacts. To evaluate the analysis’ heterogeneity and potential pleiotropy, sensitivity examinations including MR-PRESSO analysis, Cochran’s Q test, and the leave-one-out test were conducted.

Results

IVW analysis revealed that genetically decreased serum MMP-2 level were causally associated with a high risk of DN (OR = 0.88, 95% CI: 0.79-0.99, P = 0.026). Genetically elevated serum MMP-16 level were causally associated with a high risk of DN (OR = 1.15, 95% CI: 1.01-1.32, P = 0.038). Genetic prediction results showed no causal association between other MMPs (MMP14/17/9/12/7/3) and DN. Sensitivity analyses showed no significant heterogeneity or pleiotropy.

Conclusion

In summary, this research uncovered a genetic causal relationship between heightened MMP-16 levels and reduced MMP-2 concentrations, and DN risk. These discoveries offer new perspectives on the role of MMPs in DN etiology and establish a foundational premise for further investigations into MMP-targeted therapeutic interventions.
The association between working hours and working type with non-alcoholic fatty liver disease: results from the NHANES 1999-2014
Authors: Wang Ruli , Wu Ningxi , Qu Huan , Zheng Xiaowei , Zhang Haoyang , Zhu Lihong , Wang Xiaolei , Yao Xiaodie , Zhang Le
Published: January 2025

Background

Previous research has indicated that long working hours are connected to a variety of health conditions, including nonalcoholic fatty liver disease (NAFLD). However, this association which has been observed in more population is limited. Our research is designed to evaluate the association between working hours, working type, and NAFLD.

Methods

The study comprised adults with complete details on working hours, working type, and NAFLD from the NHANES 1999-2014. We employed the hepatic steatosis index (HSI) to evaluate NAFLD and examined the relationship between working hours or working type and hepatic steatosis using weighted multiple-variable regression models and restricted cubic spline (RCS) analysis. In addition, further subgroup analysis was performed based on sex, age, ratio of family income to poverty (PIR), education, and diabetes.

Results

Long working hours were significantly linked to an elevated risk of NAFLD (OR: 1.57, 95%CI: 1.21-2.05), even after controlling for confounding factors. RCS analysis suggested that there was no nonlinear relationship between them. When weekly working hours > 50, the likelihood of NAFLD among the population heightened to 57% and this risk increased to 99% in the female population. As for working type, increasing physical intensity of work was associated with higher NAFLD risk, but only heavy manual labor continued to show significance after adjustment (OR:1.39, 95%CI: 1.06-1.81). We observed that the relationship between heavy manual labor and NAFLD was more significant in the older and male populations.

Conclusion

Our results indicate that long working hours and engaging in heavy physical labor are independent risk factors for NAFLD. As working hours increase and individuals engage in heavy physical labor for extended periods, the risk of developing NAFLD significantly rises.
Transcriptional signature of CD56bright NK cells predicts favourable prognosis in bladder cancer
Authors: Khan Md Abdullah Al Kamran , Sedgwick Alexander James , Sun Yuhan , Vivian Julian P. , Corbett Alexandra J. , Dolcetti Riccardo , Mantamadiotis Theo , Mangiola Stefano , Barrow Alexander David
Published: January 2025

Human natural killer (NK) cells can be sub-divided into two functional subsets but the clinical significance of these CD56bright and CD56dim NK cells in anti-tumour immunity remains largely unexplored. We determined the relative abundances of gene signatures for CD56bright and CD56dim NK cells along with 3 stromal and 18 other immune cell types in the patient tumour transcriptomes from the cancer genome atlas bladder cancer dataset (TCGA-BLCA). Using this computational approach, CD56bright NK cells were predicted to be the more abundant tumour-infiltrating NK subset which was also associated with improved patient prognosis. A similar favorable survival trend was projected using gene signatures for mature myeloid dendritic cells (mDC) and CD8+ effector memory T cells (TEM) and unveiled a potential CD56bright NK-mDC-CD8+T cell crosstalk in the BLCA tumour microenvironment. Expression of transcripts encoding the activating NK cell receptors, NKG2D, NKp44, CD2, and CD160, showed positive survival trends in combination with CD56bright NK cell infiltration. Transcription factors including HOBIT, IRF3, and STAT2 were also correlated with CD56bright NK cell abundance. Additionally, a HOBIT-dependent tissue-residency program correlated with the CD56bright NK and CD8+ TEM cell signatures was found to be associated with favourable BLCA patient survival. Overall, our study highlights the significance of CD56bright NK cells in BLCA patient prognosis. Our findings facilitate a better understanding of the NK cell anti-tumour responses that may ultimately lead to the development of promising NK and T cell-based therapies for BLCA.