bluuebunny/crossref_metadata_2025 huggingface dataset:
Sorghum flour's effect on improving plasma lipid profile and atherogenic index in diabetic rats
Authors: Setyowati Dewi , Muna Aniq Nailil , Septiyani Anis , Widyastuti Nurmasari , Margawati Ani , Ardiaria Martha , Tsani A. Fahmy Arif
Published: July 2023

Dyslipidemia increases the risk of coronary heart disease in people with diabetes. Increased consumption of foods substantial in fiber and antioxidants, such as sorghum, can help people with diabetes manage their lipid profiles and improve insulin sensitivity. The study aimed to evaluate how sorghum flour affected diabetic rats' plasma atherosclerosis index (IAP) score and blood lipid profile. A randomized control design was used for the research's experimental methodology. In 2019, the study was carried out at P3G Laboratory UGM. 18 male Wistar rats served as the subjects and were separated into three groups: treatment (P) (5 g/mouse/day for 28 days), positive control (K+), and negative control of sorghum flour (K-). By administering nicotinamide and streptozotocin (STZ), the DM rat model was created (NA). The GPO-PAP method was used to measure TG levels. Total cholesterol, low-density lipoprotein, and high-density lipoprotein were all measured using CHOD-PAP. The log (TG/HDL) ratio (IAP) calculated the plasma atherosclerosis index. Paired T-tests, Wilcoxon, Anova, and Kruskal-Wallis, were used to evaluate the data. According to the findings, there were significant changes in the groups' baseline and post-intervention levels of total cholesterol (p=0,003), triglycerides (p=0,002), low-density lipoprotein (p=0,003), high-density lipoprotein (p=0,002), and IAP (p=0,001). In conclusion, feeding DM rats sorghum flour altered their blood lipid levels and plasma atherosclerosis index (IAP). Their LDL, triglycerides, and total cholesterol can all be reduced with a daily intake of 5 g per person.
Nutrition facts and antioxidant activity of spices biscuits as functional snacks to immune booster
Authors: Dainy Nunung Cipta , Yunieswati Wilda
Published: July 2023

The decline in the number of COVID-19 does not return people's conditions to the period before the pandemic. Efforts to prevent the spread of the coronavirus are still being carried out by implementing health protocols and keeping the body's immunity in top shape, one of which is by consuming balanced nutritious foods high in antioxidants. The research aims to develop high-antioxidant biscuits made from local flour and spices as a functional snack to increase the body's immune system. The research was held from September 2021 until January 2022 at the Faculty of Medicine and Health Universitas Muhammadiyah Jakarta. The research design was experimental, using a Completely Randomized Design (CRD). The biscuit formulation process was carried out by substituting wheat flour with purple sweet potato flour at five different ratios (4:0, 3:1, 2:2, 1:3, 0:4) and adding seven types of spices (Ginger, Cinnamon, Turmeric, Kencur, Lemongrass, Curcuma, and Cloves) with the same amount for each formula—a total of 30 semi-trained panelists in the sensory test. Data were analyzed using Kruskal Wallis. Proximate analysis and antioxidant analysis using the AOAC method and DPPH method. The results showed that the selected formula based on the sensory test was F2 with a ratio of wheat flour to purple sweet potato flour of 2:2. The hedonic test showed that there were significant differences in the color, texture, and aftertaste on biscuits (p=0,000, p=0,031, p=0,023 respectively). F2 is the formula the panelists chose, which has nutrition facts that meets SNI biscuits (2011) and has intense antioxidant activity (14,6 ug/mg).
Hubungan konsep diri dengan mekanisme koping pada pasien post operasi glaukoma di poli mata RSUD Meuraxa Banda Aceh tahun 2022
Authors: Nurhayati Nurhayati , Syamsuddin Asniah , Yusuf Meutia , Sapitri Rahmah Liya
Published: July 2023

Background: physical conditions can affect patients in forming their self-concept, patients who have a good self-concept will respect themselves, accept themselves, and do not underestimate themselves and recognize their limitations. Conversely, patients who have a poor self-concept will generally avoid their environment, tend to be alone and dissatisfied with themselves.Objectives: to determine the relationship between self-concept and coping mechanisms in postoperative glaucoma patients at the Eye Clinic at Meuraxa Hospital, Banda Aceh.Methods: this type of quantitative research with the correlation method and using the Cross Sectional Study approach. Sampling using non-probability sampling with purposive sampling technique. The number of samples was 39 patients who underwent glaucoma surgery.Results: the results of bivariate analysis showed the value of ρ = 0.002 and α = 0.05, which means that the value of p < α Ho was rejected and Ha was accepted. This means that there is a relationship between self-concept and coping mechanisms in postoperative glaucoma patients at the Eye Clinic at Meuraxa Hospital.Conclusion: that the better the patient's self-concept, the coping used is adaptive.
Uji Kadar Hambat Minimum (KHM) dan Kadar Bunuh Minimum (KBM) ekstrak daun kirinyuh (Chromolaena odorata) dari geothermal Ie Seum Aceh Besar terhadap Staphylococcus aureus
Authors: Munira Munira , Nasir Muhammad
Published: July 2023

Background: Chromolaena odorata plant is a weed that grows abundantly in various places, including geothermal areas. Its leaves contain chemical compounds such as alkaloids, flavonoids, steroids, and tannins that can function as antibacterials.Objectives: The study aims to determine the Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) of ethanol extract of Chromolaena odorata leaves grown in the geothermal area of Ie Seum Aceh Besar against Staphylococcus aureus.Methods: The study was conducted at the Fundamental Microbiology Laboratory of Aceh Besar in June 2022. The MIC and MBC tests of ethanol extract of Chromolaena odorata leaves from the geothermal area of Ie Seum Aceh Besar were performed using the liquid dilution method. The concentrations of the extract used were 1%, 3%, 5%, 7%, and 10%. The MIC was determined based on the turbidity or clarity of the test solution, while the MBC was determined by streaking each concentration of the extract/test solution on agar media. Data analysis was performed descriptively in terms of the lowest concentration of the extract that could inhibit and kill Staphylococcus aureus.Results: The results showed that the ethanol extract of Chromolaena odorata leaves from the geothermal area of Ie Seum Aceh Besar had a MIC value of 5% and an MBC value of 7% in inhibiting the growth of Staphylococcus aureus.Conclusion: Based on the study, it can be concluded that the ethanol extract of Chromolaena odorata leaves from the geothermal area of Ie Seum Aceh Besar is able to inhibit the growth of Staphylococcus aureus from a concentration of 5% and able to kill Staphylococcus aureus from a concentration of 7%.
Efektivitas ekstrak kunyit (Curcuma longa) sebagai bioinsektisida alami untuk menghalau lalat rumah (Musca domestica)
Authors: Aditama Wiwit , Zulfikar Zulfikar , Khairunnisa Khairunnisa , Arianto Budi
Published: July 2023

Background: Fly-borne diseases are still a health problem in urban and rural communities, such as diseases related to the gastrointestinal tract, such as abdominal typhus, cholera, typhoid fever, diarrhoea, dysentery, and others. The simplest and most common mode of transmission is mechanical. In this method, the vector spreads the parasite through contact with the host without the parasite breeding on the fly.Objectives: This study aimed to determine the effectiveness of turmeric extract (Curcuma longa) as a natural bioinsecticide to repel house flies (Musca domestica).Method: Quasi-experiment with only design with control design. The samples in this study were 20 houseflies in each of the two treatments and one control with three repetitions. The research was conducted at the Aceh Polytechnic Laboratory in 2022 and analyzed by ANOVA test at 95% CI.Result: It was found that the number of houseflies that rejected the administration of turmeric extract was 28, based on concentrations of 10gram/100ml, 15gram, 100ml and control (without adding extracts).At the concentration of control - 10gram/100ml (p= 0,005), 10gram/100ml - 15gram/100ml (p= 0,000), control - 15gram/100ml. There is a significant difference in each concentration (p = 0,000).Conclusion: Turmeric extract, as a natural bioinsecticide for house fly repellent, is most effective at a concentration of 15 grams/100 ml. It is suggested that the community can utilize turmeric extract can be recommended as a bio-insecticide and a house fly repellent in the household industry process.
Uji penetapan kadar asam lemak bebas minyak goreng dari kulit ayam
Authors: Prastiwi Audina , Astari Chitra , Makkasau Suhandra , Sukmawati Yuyun
Published: July 2023

Background: Currently, the Indonesian people are shocked by the scarcity of cooking oil. Demand increases yearly along with the population, making cooking oil an important commodity and essential to the Indonesian economy. The composition of broiler chicken skin contains oil. If this oil is processed into cooking oil, it will be able to overcome environmental pollution so that the broiler fat skin waste has economic value. However, the feasibility of making it a substitute for packaged cooking oil is not yet known, so further research is needed to determine its safety and feasibility.Objectives: This study aims to determine the feasibility of cooking oil from chicken skin and the free fatty acid content of cooking oil from chicken skin.Methods: The research method was experimental. The research began with the purchase of chicken skin samples from the traditional Palopo City market. Furthermore, research was carried out at the Pharmacy Laboratory of Muhammmadiyah University of Palopo, which was carried out in 2022. The primary sample of this research is chicken skin. The sample was roasted in a pan until it released oil. Then standardization of 0,05 N NaOH solution was carried out, after which free fatty acid content was determined.Results: Organoleptical test results on the two different cooking oil samples showed differences in odor, color and pH. Furthermore, it was found that the effect caused by high fatty acid levels on the production feasibility standards of oil will produce rancidity in oil and increase cholesterol levels in oil.Conclusion: Cooking oil produced by chicken skin does not meet the standards for the feasibility of use. This is due to the value of the presentation of free fatty acids, and the acidity number does not meet the applicable cooking oil quality standards.
The effect of giving moringa tempeh flour on hemoglobin levels and body weight of Wistar Rats
Authors: Suprihartini Cucuk , Ulilalbab Arya , Budiman Frenky Arif
Published: July 2023

Background: Tempeh is a fermented product that has earned the nickname "the miracle food" because of its nutritional content, especially amino acids and fatty acids, which are good for health. Moringa leaves, which are also called "the miracle leaves," have complete nutritional content, especially iron, and vitamin C. Vitamin C plays a significant role in the absorption and metabolism of ironObjectives: Was to increase absorption of iron, which can increase hemoglobin blood and body weight  of ratsMethods: There were 4 groups, each consisting of 6 rats. The rats were kept in animal laboratories at room temperature (25–27°C) for 21 days. This research was conducted from 7 to 27 October 2020 in the Pharmacology Laboratory of Medicine, Faculty of Medicine Universitas Muhammadiyah Malang. This study used a Completely Randomized Design, used 24 Rattus norvegicus with treatment conditioned with anemia. The four groups were divided into control anemia rats, control non-anemia rats, anemia rats that consumed tempeh, and anemia rats that consumed tempeh with moringa leaves of 4%. The rats body weight was weighed daily and the blood Hb was taken at the end of the treatment. Statistical test used One-way Analysis of Variance (α = 0,01).Results: The results of statistical tests with ANOVA show not significant influence. The results of the hemoglobin and body weight rats had no significant effect.Conclusion: The value was not significant between groups in the hemoglobin assessment, but the treatment group that was given moringa leaves tempeh was higher than the anemia control group and the pure tempeh group.
Pengaruh terhadap lama perendaman buah rosella (Hibiscus sabdariffa L) melalui uji kadar vitamin C secara spektrofotometri UV-VIS
Authors: Bahrum Shela Binti , Umar Anugrah , Jasril Jasril
Published: July 2023

Background: rosella fruit is a fruit that has a high enough vitamin C content. Vitamin C is needed for collagen production and helps the body's metabolic processes. Vitamin C dissolves easily in water and is easily damaged, so care must be taken to get a high enough content. Vitamin C levels are essential to measure, one of which is by using the UV-VIS spectrophotometry method. This study aims to determine differences in vitamin C levels through the length of soaking rosella fruit, commonly used among the public as an alternative to herbal medicine.Objectives: to determine differences in levels of vitamin C in rosella fruit samples through soaking time as is often done among people who drink rosella fruit boiled water as an alternative to herbal medicine.Methods: the design of this research is experimental research, namely to determine the level of vitamin C in rosella fruit soaking through soaking time (10 minutes, 20 minutes, and 30 minutes). Tests were carried out using UV-VIS Genesis spectrophotometry.Results: the study found that the levels of vitamin C found in rosella fruit soaking for 10 minutes was 117.9 mg/50 g, soaking for 20 minutes was 74.778 mg/50 g, and soaking for 30 minutes was 69.621 mg/50 g.Conclusion: this shows that the level of vitamin C content is higher in 10 minutes of immersion compared to 20 and 30 minutes of immersion. Rosella fruit has the potential as a source of vitamin C, therefore, it is recommended to pay attention to the long soaking time of rosella fruit because the longer the soaking time of rosella fruit, the less vitamin C content in the fruit will be
Pengaruh penerapan program Sanitasi Total Berbasis Masyarakat (STBM) dengan kejadian diare di Wilayah Kerja Puskesmas Darul Imarah
Authors: Syahrizal Syahrizal
Published: July 2023

Background: Sanitation is a dominant environmental health problem. Poor environmental conditions make contracting diseases such as diarrhea and infectious diseases easier. The problem in this study was how to evaluate the implementation of the community-based total sanitation program with the incidence of diarrhea in the working area of the Darul Imarah Health Center.Objectives: This study aimed to determine the effect of community-based total sanitation program pillar 1 (Stop BABS) on the incidence of diarrhea.Methods: This type of research is descriptive research with a cross-sectional study design. The sample in this study was the total population of 32 villages in the working area of the Darul Imarah health center. This study was conducted in February 2022. Primary and secondary data were collected. Data were collected through in-depth interviews and documentation studies at the Darul Ilmarah Health Center Data Section. The data collected included data on STBM programs in all villages, open defecation data, and open Defecation Free) data. Data analysis was performed descriptively to compare this study.Results: Most of the residents who have private permanent healthy latrines built their sanitation facilities before the StBM program was first introduced by the government and puskesmas sanitation officers. The types of latrines used varied, with the average resident using a gooseneck squatting latrine and a gooseneck sitting latrine, most of which were equipped with a sanitary final disposal site for feces, namely a septic tank.Conclusion: Implementing the first pillar of the STBM program or stopping defecation in the working area of the Darul Imarah Health Center has not yet reached the 100% target, and no village has reached ODF conditions. In addition, the incidence of diarrhea has increased from 2020 to 2021.
Aplikasi Pengenalan Kampus Universitas Nurul Jadid Berbasis Virtual Reality
Authors: Firdaus Agung Wahyu , Pratamasunu Gulpi Qorik Oktagalu , Fajri Fathorazi Nur
Published: July 2023

Universitas Nurul Jadid (UNUJA) di Paiton, Probolinggo, Jawa Timur, telah mendapatkan sertifikasi ISO di dua bidang, yaitu ISO 9001:2015 untuk sistem manajemen mutu dan ISO 21001:2018 untuk sistem manajemen pendidikan. UNUJA merupakan pondok pesantren pertama yang terakreditasi dengan cara ini. Prestasi UNUJA ini menunjukkan peningkatan kualitas kampus dan telah diakui oleh standar Internasional. Sebagai salah satu bentuk pengenalan kampus, UNUJA masih menggunakan website, brosur dan media lainnya. Informasi yang diberikan masih kurang, sehingga siswa tidak mengetahui bangunan mana yang akan mereka gunakan dalam kegiatan belajar mengajar. Dengan berkembangnya teknologi, interaktivitas menjadi salah satu fokus pembuatan aplikasi. Teknologi interaktif yang berkembang saat ini adalah teknologi virtual reality. Virtual Reality adalah tampilan gambar 3D yang dibuat oleh komputer yang dibuat tampak nyata dengan menggunakan berbagai teknik, memberikan kesan kepada pengguna bahwa ia terlibat secara aktif dengan lingkungan tersebut. Pengujian internal dan eksternal untuk menguji aplikasi secara langsung kepada pengguna. Untuk menguji pandangan, sikap, atau pendapat pengguna, peneliti menggunakan kuesioner pada skala Likert. Hasil perhitungan dengan menggunakan metode skala likert diperoleh data sebesar 97% yang artinya Aplikasi Pengenalan Kampus Universitas Nurul Jadid sangat baik dan layak digunakan sebagai media promosi kampus.
Implementasi Metode Certainty Factor Untuk Diagnosis Kerusakan Software Pada Smartphone Berbasis Web
Authors: Afwan Rizky , Astuti Indah Fitri , Cahyadi Dedy
Published: July 2023

Smartphone merupakan alat komunikasi antara dua orang atau lebih, saat ini tidak hanya berkomunikasi, beberapa fungsi lainnya sudah tersedia, serta beberapa smartphone memiliki kinerja layaknya komputer. Komponen teknologi umumnya tidak dapat terhindar dari kerusakan. Kerusakan yang terjadi pada smartphone sebagian besar masyarakat awam tidak tahu pasti kerusakan apa yang dialami. Tujuan yang ingin dicapai dalam penelitian ini adalah membentuk sebuah sistem yang dapat melakukan diagnosis terhadap suatu kerusakan smartphone berdasarkan pola pikir pakar atau ahli. Penelitian ini menggunakan metode Certainty Factor untuk mengakomodasi ketidakpastian seorang pakar. Data yang digunakan merupakan hasil wawancara bersama pakar selaku teknisi Smartphone Care dan ditemukan 6 jenis kerusakan yang dapat disebabkan oleh software yaitu Light Bootloop, Medium Bootloop, Hard Bootloop, Soft Brick, Hard Brick, dan Freeze. Hasil pengujian dari 6 data, diperoleh hasil diagnosis jenis kerusakan yang terjadi berdasarkan gejala yang dialami oleh user. Hasil akurasi dari perhitungan manual dan sistem memiliki tingkat akurasi 83,3%, sedangkan hasil akurasi dari perhitungan sistem dengan hasil diagnosis pakar memiliki tingkat akurasi 100%. Hasil diagnosis kerusakan metode certainty factor ini bisa menjadi bahan pertimbangan untuk para pengguna smartphone awam menggunakan sistem dalam melakukan diagnosis pada smartphone lebih dini tanpa datang ke teknisi untuk melakukan perbaikan.
Rancang Bangun Sistem Informasi Geografis Berbasis Web : Tinjauan Literatur Sistematis (SLR)
Authors: Mirwansyah Dedy , Mahdiana Deni
Published: July 2023

Penelitian tinjauan literatur sistematis (SLR) mempelajari berbagai metode pengembangan sistem, metode perancangan, Bahasa pemograman, software database serta platform pemetaan yang digunakan pada pembangunan dan perancangan sistem informasi geografis berbasis web dalam berbagai bidang. Sistem Informasi Geografis (SIG) adalah suatu sistem spasial berbasis komputer yang digunakan untuk menyimpan, mengoleksi, memanipulasi, mengolah informasi geografis dan pengambilan data keruangan permukaan bumi. Pada penelitian ini akan dilakukan beberapa tahapan yaitu Mencari kesamaan (Compare), Mencari ketidaksamaan (Contrast), Memberikan pandangan (Criticize), Membandingkan (Synthesize) dan Meringkas (Summarize), pada tahapan selanjutnya dibuat Research Question untuk mengetahui metode-metode yang sering digunakan dalam membangun SIG berbasis website. Penelitian ini akan melakukan tinjauan literatur 2018 – 2022 sehingga akan didapati metode yang sedang trend dan lebih baik dalam pembangunan SIG.
Rancang Bangun Computer Assited Test (CAT) Untuk Pendidikan SD di Masa Pandemi Covid-19
Authors: Irwansyah Irwansyah , Pangestu Muhammad Aji , Fitriani Nia , Mauliddina Rindy
Published: July 2023

Dalam perkembangan Teknologi Informasi sangat berkembang pesat seiring zaman termasuk dunia pendidikan, Teknologi Informasi juga sebagai trobosan solusi dalam permasalahan didunia pendidikan salah satunya ada untuk kegiatan pembelajaran dimasa pandemi Covid-19. Salah satunya adalah CAT (Computer Assited Test) dengan menggunakan PHP dan Mysql dan dengan adanya ini bisa membantu untuk sistem penilaian yang secara langsung, bisa menganalisa jawaban dan soal dan bisa mempermudah walaupun terhantam pandemi Covid-19.
УКРАЇНСЬКА ЕКОНОМІКА ПРИРОДОКОРИСТУВАННЯ: ПРОБЛЕМИ ТА ПЕРСПЕКТИВИ РОЗВИТКУ В РЕАЛІЯХ ГЛОБАЛЬНОЇ НЕСТАБІЛЬНОСТІ
Authors: Поясник Георгій
Published: July 2023

УДК 338.1:504.75; JEL Classification: O13

Поясник Г.В. УКРАЇНСЬКА ЕКОНОМІКА ПРИРОДОКОРИСТУВАННЯ: ПРОБЛЕМИ ТА ПЕРСПЕКТИВИ РОЗВИТКУ В РЕАЛІЯХ ГЛОБАЛЬНОЇ НЕСТАБІЛЬНОСТІ

Мета. Стаття присвячена вивченню проблем та перспектив розвитку української економіки природокористування в контексті глобальної нестабільності. Мета дослідження - показати вплив глобальної нестабільності, зокрема російсько-української війни на економіку природокористування. Методика дослідження. Для досягнення поставленої мети, у статті використані методи наукового аналізу, синтезу та порівняння. Виконано огляд літератури та аналізування статистичних даних, що дозволило отримати реальну картину сучасного стану української економіки природокористування. Результати. Результати дослідження вказують на існуючі проблеми, такі як недостатнє ефективне використання природних ресурсів, недостатня регуляторна база та недосконалість механізмів контролю. Крім того, виявлено негативний вплив глобальної нестабільності, зокрема війн та конфліктів, на економіку природокористування в Україні. Російсько-українська війна, яка триває з 2022 по 2023 рік, має негативний вплив на економіку та природокористування. Бойові дії призвели до обстрілу промислових та інфраструктурних об'єктів, спричиняючи пожежі та забруднення повітря, ґрунту та води. Знищення лісів та використання деревини для військових потреб порушили природні біоценози. Контроль над радіаційно небезпечними об'єктами в Чорнобильській зоні був втрачений, що призвело до підвищення рівня радіаційного фону та загрози для радіаційної безпеки. Крім того, бойові дії порушили спокій диких тварин та загрожують виживанню їх потомства. Це має вплив на біологічну різноманітність та екологічну рівновагу. Усі ці фактори в сукупності викликали значні збитки в економіці та природокористуванні під час російсько-української війни 2022-2023 року. Наукова новизна. Практичне значення статті полягає у визначенні основних напрямів подолання проблем та розвитку української економіки природокористування в умовах глобальної нестабільності. Практична значущість. Результати дослідження можуть бути використані для розробки ефективних стратегій та політик у сфері природокористування, а також для прийняття відповідних рішень на рівні державного управління з метою забезпечення сталого розвитку та екологічної безпеки.
РАЦІОНАЛІЗАЦІЯ ВИКОРИСТАННЯ ТРИЄДНОСТІ ОСНОВНИХ РЕСУРСІВ (ТРУДОВИХ, МАТЕРІАЛЬНИХ, ФІНАНСОВИХ) ЯК НАПРЯМ ПІДВИЩЕННЯ КОНКУРЕНТОСПРОМОЖНОСТІ ПІДПРИЄМСТВА
Authors: Прокопенко Микола , Костенко Юрій
Published: July 2023

УДК 339.137; JEL Classification: D 41

Прокопенко М.В., Костенко Ю.О. РАЦІОНАЛІЗАЦІЯ ВИКОРИСТАННЯ ТРИЄДНОСТІ ОСНОВНИХ РЕСУРСІВ (ТРУДОВИХ, МАТЕРІАЛЬНИХ, ФІНАНСОВИХ) ЯК НАПРЯМ ПІДВИЩЕННЯ КОНКУРЕНТОСПРОМОЖНОСТІ ПІДПРИЄМСТВА

Мета дослідження полягає у вивчення теоретичних аспектів процесу підвищення конкурентоздатності підприємства в сучасних умовах господарювання та розробки пропозицій щодо їх вдосконалення за допомогою раціонального поєднання основних ресурсів підприємства (трудових, фінансових та матеріальних) та математико-статистичного прогнозування. Методика дослідження. Було застосовано статистичний аналіз, математичне допущення, задіяні середні, максимальні та граничні показники, прийоми «раціоналізації» об’єднань показників, побудовано графік залежності кінцевих результатів від ефективності фінансової діяльності, застосовано методи економетричного та статистичного моделювання. Результати дослідження. Основним завданням дослідження був аналіз та розробка шляхів підвищення конкурентоздатності підприємства. Результатом дослідження є доведена можливість використання раціоналізації сумісного використання трьох основних ресурсів підприємства (трудових, фінансових та матеріальних) з метою підвищення рівня конкурентоспроможності. Для моделювання та отримання економіко-статистичної моделі було використано програму Microsoft Excel. Наукова новизна. Наукова новизна отриманих результатів полягає в аналізі та розробці теоретико – практичних засад вирішення проблеми підвищення конкурентоспроможності підприємства за допомоги «ресурсного» підходу. Запропонована методика аналізу можливості підвищення конкурентоспроможності підприємства за допомогою використання елементів раціоналізації співвідношення основних ресурсів підприємства (трудових, фінансових та матеріальних), модель реалізована у середовищі Microsoft Excel. Практичне значення отриманих результатів. Отримані результати дослідження дають можливість визначити раціональне співвідношення між значеннями фінансово-господарських показників суб'єкта господарювання, реально досяжне при конкретних початкових параметрах. Практична сторона дослідження дозволяє на основі розробленого підходу управління підприємством досягти максимальної ефективності використання ресурсів і сприятиме зростанню конкурентоспроможності на внутрішньому і міжнародному ринках.
Systematicity and integrity of language in the context of integrated knowledge about human
Authors:   Institute of Philology (Siberian Branch) of the Russian Academy of Sciences, Shaposhnikova Irina V.
Published: July 2023

The article states that the systematicity of language is formed on the basis of its ontological integrity and becomes available for study only in the light of interdisciplinarity with reference to the basic dimensions of Human species-specific organization of mind and brain activities. The author offers a working definition of the language system in the context of its integrity, considers epistemological issues related to the emergence of conceptually different approaches to the explication of language systematicity, focuses on the role of material substrate of the language, considers fundamental domestic contribution to the development of the general theory and systemology of language proceeding from the ontological grounds for its integrity. The author touches upon applied significance of this approach for the development of the general theory of language and its practical implementation at such Universities where courses of general linguistics are taught, as well as in the construction of interdisciplinary dialogue, and in the study of problematic aspects of interethnic communication. On the example of the psychological meanings of several lexemes functioning as operators in the promotion of ethnopolitical concepts which are behind culture-bound scenarios of different participants in interethnic communication, the author shows the role of the integrity of the image of the world as a semantic substrate of language consciousness in the adaptation of ethnopolitically marked borrowings in the Russian language. The analysis was carried out on the basis of the latest associative-verbal databases collected within the framework of the SIBAS project (Siberia and the Far East: 2008-2022), in comparison with similar, earlier all-Russian and synchronous European sources.
Declared vs practiced strategies by polyglot Steve Kaufmann
Authors:   Institute of linguistics, RAS, Nikulicheva Dina B.
Published: July 2023

Based on the study of the works of the Canadian polyglot Steve Kaufmann, a new aspect in the study of polyglottery is proposed: a comparison of linguodidactic principles that polyglots themselves formulate in their publications with those specific language learning strategies that can be identified by analyzing the language platforms created by polyglots to teach other people. In particular, the article studies conscious and unconscious attitude of polyglots to authentic educational materials and designed courses; ways of mastering grammatical forms, communication with the real and imaginary world, the use of parallel texts when learning new languages, the use of regional variants, varying the speed of educational audio materials, the use of special technical approaches to increase the motivation and optimize students’ time management.
TRANSFORMATION OF THE ORGANIZATIONAL STRUCTURE OF A TRANSPORT COMPANY MANAGEMENT AS A MEANS OF ADAPTATION TO CHANGES IN THE ENVIRONMENT
Authors: Pismennaya Anna , Tochalnaya Alyona
Published: July 2023

The influence of changes of typical organizational management structures in transport companies on the effectiveness of its adaptation to the changing environment is analyzed.

The impact is studied which affects the efficiency indicators of increasing the intensity of communication flows, including the formation of the position of a communication broker in the organization structure, an increase in the number of communication channels per agent, an increase in the intensity of interaction between individual agents when using modern means of communication, such as corporate messengers, online meetings, videoconferences.

The research method is numerical modeling of the behavior of a transport industry company, presented as a set of interacting agents. The nature of the organization model construction reflects the prevailing organizational culture in it (the study considers models of two types of organizational culture – hierarchy and adhocracy).

The novelty of the work is in quantifying the effectiveness of the transport organization in processing information about changes in the environment through modifications of the organizational structure.

The results of the study show that the organizational effectiveness is determined by the static and dynamic characteristics of the organizational management structure. Static characteristics include the depth of hierarchy levels, the density of interaction between agents and departments in the organization; dynamic characteristics include the speed of information dissemination, indicators of the impact of agents on each other.

Conclusions. A comprehensive analysis of the environment, the organizational structure of management and the level of training individual agents that make up the organization allows to select a modification of the communication environment that ensures an increase in the effectiveness of the adaptive abilities of the transport industry organization.
MODELING OF RESIDUAL DEFORMATIONS OF A TANK CAR BOILER BASED ON CREEP THEORY
Authors: Surnin Artem , Bespal'ko Sergey
Published: July 2023

The study objective is to determine the effect of residual deformations on the behavior of the boiler during operation.

Tasks: to develop a creep model based on flow theory and a methodology for calculating creep deformations of a railway tank boiler that occur during long-term operation. The methods of elasticity and creep theory, finite element method are used.

The novelty of the work is in the development of a methodology for determining residual deformations in the boiler of a tank car. The results of the study are the dependences of the value of residual deformations on various factors, the deformation of the boiler in the support zones, the selection of parameters of the creep model.

Conclusions: in the study, the creep state equation is modeled, on which basis calculations of various technical solutions for reducing residual deformations in the boiler are carried out. The options are compared.
STUDY OF THE EFFECT OF EXCESSIVE SOLAR RADIATION AND LATERAL WIND LOAD ON THE ASSESSMENT OF THE BODY STRENGTH OF A DOUBLE-DECK CAR
Authors: Sorokina Elena , Korshunov Sergey , Boldyrev Aleksey , Lozbinev Fedor
Published: July 2023

Approaches to the analysis of the load-bearing systems of the bodies of double-deck cars, as well as the experience of their operation on domestic railways are analyzed. It is found out that for modern load-bearing structures of bodies with minimum permissible safety margin and stability of elements, it is advisable to pay more attention to specific loads, such as wind and loads associated with excessive solar radiation.

The method of studying the influence of these factors on the load-bearing capacity of the elements of car body pressure shell is proposed. The method provides for both experimental simulation of exposure of the double-deck car roof with excessive solar radiation in combination with subsequent exposure to repair loads, and carrying out a complex of calculations based on the application of the finite element method (FEM).

The conducted studies indicate the need for a more precise account of the influence of lateral wind load and excessive solar radiation when assessing the strength of the load-bearing structures of the double-deck car bodies.

It is shown that the proposed technique makes it possible to take into account these specific loads on the basis of mathematical modeling with confirmation of the results obtained by the data of field experiments.
PREVALÊNCIA DE LESÕES POR PRESSÃO EM UM HOSPITAL DE TRANSIÇÃO NO MUNICÍPIO DE BELO HORIZONTE
Authors: Lamounier Neves Társila , Silva Ferreira Brisa Emanuelle , Teixeira Moraes Juliano , Cristiane Gandra Elen , Alves Rodrigues Simone
Published: July 2023

Objetivo: determinar a prevalência de lesão por pressão em um hospital de transição do cuidado do município de Belo Horizonte, Minas Gerais, Brasil. Método: Trata-se de  um estudo transversal e retrospectivo. A população foi constituída por 685 pacientes que estiveram internados no hospital e com assistência registrada em prontuários no ano de 2018. Resultados: A prevalência de pacientes com  lesão por pressão nesse estudo foi de 14% (Intervalo de Concordância = 7% e 22%). Os pacientes com maior ocorrência de lesão por pressão da instituição eram do sexo masculino (52%), com idade entre 75 a 84 anos (33%) e pele de cor parda (51%). Apesar da maioria dos pacientes estarem em risco de lesão por pressão, a instituição possui uma baixa prevalência de lesão quando comparada ao encontrado na literatura. Neste estudo, os indivíduos acima de 60 anos possuem maior risco de lesão por pressão. O tempo médio para abrir lesão foi o mesmo entre os estágios. Observa-se também que a maioria das lesão por pressão estão localizadas em áreas anatômicas de maior pressão e ocorrem quando o paciente se encontra em decúbito dorsal. Conclusão: Pode-se concluir que as lesão por pressão constituem um sério problema comumente identificável no contexto assistencial. Medidas de prevenção devem ser adotadas.
Modern Radiotherapy and Cardiac Toxicity in Breast Cancer
Authors: Iorio Giuseppe Carlo , Chiofalo Valeria , Ricardi Umberto
Published: July 2023

Radiotherapy (RT) is a mainstay of Breast Cancer (BC) patients therapy. Nonetheless, unintended irradiation of the heart and its substructures can result in cardiac toxicity, jeopardizing long-term survivors’ quality of life (QOL). Advances in RT delivery techniques deeply impacted this clinical scenario. Indeed, given the non-negligible burden of cardiotoxicity, modern cardiac sparing approaches have a pivotal role. Nonetheless, further evidence is eagerly awaited regarding patients’ selection, clinical predictors, biological markers, and particularly heart substructures dose-constraints.
Gynecological Malignancies in Albania: The Challenges of Cancer Care in a Low Resource Country
Authors: Mati Kleida , Pozzo Carmelo , Cekani Elona , Qeraj Kleva , Prifti Jona , Pecini Olti , Elmasllari Arlinda , Skoku Fatilba , Romagnolo Cesare
Published: July 2023

Objective: This literature review aims to provide a comprehensive assessment of the current state of gynecological cancers in Albania, including their epidemiology, screening, diagnosis, and treatment. It also aims to highlight the challenges that Albanian patients face in accessing appropriate treatment and to discuss the importance of data collection. This is the first comprehensive review of gynecological cancers in Albania. Mechanism: A comprehensive literature search was conducted using various databases to identify relevant studies and government reports. Government reports were used to supplement the data obtained from the International Agency for Research on Cancer and provide additional insights into the challenges and limitations of cancer data collection in Albania. Findings in Brief: Albania has a population of 1.18 million women aged 15 years and older who are at risk of developing gynecological cancers. The most prevalent gynecological cancers among Albanian women are endometrial, cervical, and ovarian cancers. Cervical cancer accounts for 30% of all gynecological cancers and is the main cause of cancer-related mortality in this group. Albanian women are at a lower risk of developing gynecological cancers than women in neighboring countries. The main risk factors for gynecological cancers in Albanian women include increasing age, obesity, and human papillomavirus (HPV) infection. However, no data are available on germline mutations associated with a hereditary risk of developing gynecological cancers. Recently, Albania has introduced a cervical cancer screening program along with HPV vaccination. Nonetheless, owing to lack of awareness and education about the disease and limited access to early screening programs, gynecological cancers are often detected at later stages. Treatment options for gynecological cancers in Albania remain largely unchanged and have not adapted to new molecular classification methods that could affect treatment decisions. Furthermore, new therapeutic options, such as immunotherapy and targeted agents, are not commonly used for gynecological cancers in Albania. Conclusions: Gynecological cancers remain a significant public health issue in Albania. Urgent action is needed to address the increasing burden of gynecological cancers, including investment in cancer control strategies, primary prevention, early detection, treatment, healthcare infrastructure, capacity building, and research to address specific national needs and implement evidence-based policies.
Therapeutic Approaches to Vulvar Cancer: A Review of Literature
Authors: D'Augè Tullio Golia , Firulli Ilaria , Di Bartolomeo Giorgia , Cuccu Ilaria , Turetta Camilla , Trezza Angelo , Bogani Giorgio , Palaia Innocenza , Perniola Giorgia , Tomao Federica , Muzii Ludovico , Di Donato Violante , D'Oria Ottavia , Giannini Andrea
Published: July 2023

Objective: Vulvar cancer is a rare gynecological cancer that mainly affects postmenopausal women. The aim of this review is to analyze the most recent data available in the literature on the clinical and therapeutic approach to vulvar carcinoma. Mechanism: Studies available in the literature on the therapeutic management of patients with vulvar carcinoma until November 2022 have been screened. A comprehensive search was performed in the PubMed (MEDLINE), EMBASE, SCOPUS and Web of Science databases. Findings in Brief: The approach to vulvar carcinoma has deeply evolved over the years. The management of early-stage vulvar carcinomas is well established and widely shared, while that of advanced and recurrent cancers is a subject of debate. The assessment of the nodal status has changed from the past with the passage from inguinal lymphadenectomy to the removal of only the sentinel node. Conclusions: The gold standard for the management of vulvar cancer is surgery, applicable in the first instance in early-stage tumors and after neoadjuvant therapy for larger tumors. Assessment of the nodal state is crucial and the method to be used depends on the degree of suspicious of positive lymph nodes. The prognosis is good if the treatment is applicable as soon as possible.
Preparation and Characterization of Allicin-Loaded Solid Lipid Nanoparticles Surface-Functionalized with Folic Acid-Bonded Chitosan: In Vitro Anticancer and Antioxidant Activities
Authors: Alyasiri Faris J. , Ghobeh Maryam , Tabrizi Masoud Homayouni
Published: July 2023

Objective: This investigation aimed to increase the bioavailability and anticancer effects of allicin (AC) by encapsulating it in solid lipid nanoparticles (SLN) decorated with chitosan (CS)-conjugated folic acid (FA). Material and Methods: Nanoparticles (NPs) were synthesized by high-pressure homogenization, and then, Fourier-transform infrared (FTIR), Field-Emission Scanning Electron Microscopy (FESEM), Dynamic Light Scattering (DLS), and zeta potential methods were used to determine their physicochemical characteristics. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay was performed to assess the effect of toxicity and flow cytometry, while fluorescent staining methods were used to investigate the type of cell death. Real-time quantitative polymerase chain reaction (qPCR) was used to evaluate the expression levels of apoptotic genes: Bcl-2, and caspase-8. Results: The presence of AC-SLN-CS-FA with a spherical morphology, an average size of 86.7 ± 9.4 nm, uniform distribution (0.31), a surface charge of +21.3 ± 13.3 mV, an encapsulation percentage of 86.3%, and a folate binding rate of 63% confirmed the success of the preparation method. Suppression of MCF-7 cancer cells and non-toxicity of AC-SLN-CS-FA on Human foreskin fibroblast (HFF) normal cells were confirmed by cytotoxic assay. The results of flow cytometry revealed that the cells were arrested in the sub-G1 phase, and the activation of the intrinsic apoptosis pathway was confirmed by the results of real-time qPCR. Conclusions: In general, AC-SLN-CS-FA has the potential to prevent free radicals and trigger apoptosis in cancer cells by activating the intrinsic apoptosis pathway; thus, making it a promising subject in preclinical research.
Hydroxychloroquine Toxicity in the Vital Organs of the Body: In Vivo Study
Authors: Alruwaili Meshref , Jarrar Bashir , Jarrar Qais , Alruwaili Majed , Goh Khang Wen , Moshawih Said , Ardianto Chrismawan , Ming Long Chiau
Published: July 2023

Background: Hydroxychloroquine (HCQ) toxicity can adversely affect vital organs, cause pathologic ocular damage, and can have direct cardiovascular effects. This study aims to identify the biochemical, hematological, and histological alterations of the vital organs associated with the effects of HCQ. Methods: Male albino rats were exposed to the equivalent of HCQ therapeutic doses given to human patients being affected by malaria, lupus erythematosus, and COVID-19. The animal blood samples were subjected to hematological analysis, biochemical analysis, liver function tests, kidney function tests, and cardiac biomarkers. Liver, kidney, heart, spleen, and testis biopsies were subjected to histological examination. Results: HCQ significantly lowered the values of erythrocytes, hemoglobin, hematocrit, platelets, leucocytes, and lymphocytes but significantly increased the values of aspartate aminotransferase (AST), alanine aminotransferase (ALT), amylase, alkaline phosphatase, lactate dehydrogenase, cholesterol, and chlorine ions. The renal tissues of HCQ-treated animals demonstrated glomerular fragmentation, partial atrophy degeneration, renal tubules hydropic degeneration, hyaline cast formation, and interstitial edema formation. Additionally, the heart exhibited myofiber necrosis, myolysis, wavy appearance, disorganization, and disarray. The testicular tissues also demonstrated spermatocyte degeneration, spermatogenic cell sloughing, testicular interstitial edema, and occasional spermatogenic arrest. Additionally, the spleen showed a decrease in the number and size of the white pulp follicles, a decrease in the number of apoptotic activity, and a decline in the number of T-rich cells. However, the red pulp demonstrated a diffuse decline in B rich-lymphocytes and macrophages. The liver was also the least affected but showed Kupffer cell hyperplasia and occasional hepatocyte dysplasia. Conclusions: The results indicate that chronic exposure to HCQ could alter the structures and functions of the vital organs.
Linkage Disequilibrium between LDLR rs688 and AvaII Genes and its Significant Association with Ischemic Stroke
Authors: Chen Yabin , Cai Hehui , Zhang Jianming , Su Yongfa , Wu Yibo , Lin Zhenzhong , Zhang Zhishan
Published: July 2023

Background: To analyze the polymorphism distribution of low density lipoprotein receptor rs688, AvaII, NcoI gene in ischemic stroke, and explore the linkage disequilibrium among them. The correlation between the linkage disequilibrium and ischemic stroke was further analyzed. Methods: The levels of serum lipid (triglyceride, cholesterol, high density lipoprotein cholesterol, low density lipoprotein cholesterol, apolipoprotein A1, apolipoprotein B) and rs688, AvaII, NcoI polymorphism of low density lipoprotein receptor gene were tested in patients with ischemic stroke (n = 140), healthy control (n = 129) and patients with other cerebrovascular diseases (n = 122). Chi-square test was used to compare the gene frequency and allele frequency of each group. Both the linkage disequilibrium of the three genes and the alleles correlated with ischemic stroke were analyzed. The correlation of linkage disequilibrium gene and ischemic stroke was analyzed with logistic binary regression. Results: In the ischemic stroke group, significant difference was observed in frequencies and allelic frequencies of low density lipoprotein receptor (LDLR) rs688 and AvaII. No difference of NcoI was found. Linkage disequilibrium was found for rs688 and AvaII (D’ = 0.927, R2 = 0.509). Allelic genes correlate with ischemic stroke included T of rs688 (X2 = 46.105, p < 0.001) and C of AvaII (X2 = 20.436, p < 0.001). Conclusions: Linkage disequilibrium existed between LDLR rs688 and AvaII genes. With the wild type gene (WT) (rs688/AvaII: CC/TT) as reference, rs688/AvaII: CT/TC, CT/CC and TT/CC increased the risk of ischemic stroke, which might be a genetic marker used for the screen of high-risk population contributing to the prevention of the disease.
S-ICD Implantation "Tips and Tricks"
Authors: Budrejko Szymon , Kempa Maciej , Przybylski Andrzej
Published: July 2023

An implantable cardioverter-defibrillator (ICD) was developed to provide protection against sudden cardiac death. Despite being effective in terminating ventricular arrhythmias, traditional transvenous ICDs appeared over time to have certain limitations related to the need for vascular access and the presence of foreign material inside the circulatory system (namely lead failure and infections). A subcutaneous implantable cardioverter-defibrillator (S-ICD) was developed to overcome those limitations and to provide prevention against sudden cardiac death from outside the cardiovascular system. Utilization of that modern method of treatment is constantly increasing worldwide, and new centers incorporate implantation of that system in their portfolio. This review aims to present the most relevant issues related to S-ICD implantation procedure, based on experience of the authors and an extensive literature search.
Understanding the Development of Place Attachment Among Young People in Resettlement Sites: Insights from the Mindsponge Mechanism
Authors: Duong Thi Minh Phuong
Published: July 2023

The mindsponge mechanism framework is used to examine how young people incorporate and process information they encountered in the resettlement sites, and how this information processing influenced their attitudes, emotions, and sense of connection to the place, and eventually assisting to foster place attachment