bluuebunny/crossref_metadata_2025 huggingface dataset:
New cancer cases attributable to diet among adults aged 30–84 years in France in 2015
Authors: Shield Kevin D. , Freisling Heinz , Boutron-Ruault Marie-Christine , Touvier Mathilde , Marant Micallef Claire , Jenab Mazda , Deschamps Valérie , Hill Catherine , Ferrari Pietro , Margaritis Irène , Bray Freddie , Soerjomataram Isabelle
Published: November 2018

This study aimed to estimate the number of new cancer cases attributable to diet among adults aged 30–84 years in France in 2015, where convincing or probable evidence of a causal association exists, and, in a secondary analysis, where at least limited but suggestive evidence of a causal association exists. Cancer cases attributable to diet were estimated assuming a 10-year latency period. Dietary intake data were obtained from the 2006 French National Nutrition and Health Survey. Counterfactual scenarios of dietary intake were based on dietary guidelines. Corresponding risk relation estimates were obtained from meta-analyses, cohort studies and one case–control study. Cancer incidence data were obtained from the French Network of Cancer Registries. Nationally, unfavourable dietary habits led to 16 930 new cancer cases, representing 5·4 % of all new cancer cases. Low intake of fruit and dietary fibre was the largest contributor to this burden, being responsible for 4787 and 4389 new cancer cases, respectively. If this is expanded to dietary component and cancer pairs with at least limited but suggestive evidence of a causal association, 36 049 new cancer cases, representing 11·6 % of all new cancer cases, were estimated to be attributable to diet. These findings suggest that unfavourable dietary habits lead to a substantial number of new cancer cases in France; however, there is a large degree of uncertainty as to the number of cancers attributable to diet, including through indirect mechanisms such as obesity, and therefore additional research is needed to determine how diet affects cancer risk.
Vitamin E intake and risk of stroke: a meta-analysis
Authors: Cheng Pengfei , Wang Lihua , Ning Shujun , Liu Zichun , Lin Hao , Chen Shuli , Zhu Jiaying
Published: November 2018

Findings from observational studies on the associations between vitamin E intake and stroke risk remain controversial, and the dose–response relationship between vitamin E intake and risk of stroke remains to be determined. We conducted a meta-analysis of prospective studies aiming to clarify the relationships between vitamin E intake and risk of stroke. Relevant studies were identified by searching online databases through to June 2018. We computed summary relative risks (RR) with corresponding 95 % CI. Among 3156 articles retrieved from online databases and relevant bibliographies, nine studies involving 3284 events and 220 371 participants were included in the final analyses. High dietary vitamin E intake was inversely associated with the risk of overall stroke (RR=0·83, 95 % CI 0·73, 0·94), and with the risk of stroke for individuals who were followed-up for <10 (RR=0·84, 95 % CI 0·72, 0·91). There was a non-linear association between dietary vitamin E intake and stroke risk (P=0·0249). Omission of any single study did not alter the summary result. In conclusion, this meta-analysis suggests that there is a significant inverse relationship between dietary vitamin E intake and stroke risk. This meta-analysis provides evidence that a higher dietary vitamin E intake is associated with a lower stroke risk.
Mainstreaming Effective Employment Support for Individuals with Health Conditions: An Analytical Framework for the Effective Design of Modified Individual Placement and Support (IPS) Models
Authors: Whitworth Adam
Published: November 2018

Individual Placement and Support (IPS) is a highly effective model of employment support for individuals with severe mental health conditions. Its potential modification for new settings and larger cohorts is of keen interest across advanced economies given shared health-related (un)employment challenges. Despite mushrooming policy interest and activity around modified IPS a significant barrier and risk at present is the absence of a well-considered analytical framework to enable structured critical reflection about the effective translation of IPS principles and fidelity into modified IPS services. This article fills this void through the presentation for the first time in the literature of such an analytical framework, unpacking as it does so a set of key original analytical distinctions that are unhelpfully homogenised in current literature and policy thinking and highlighting the wider potential of IPS principles and models to the nature of good employment support for other individuals with health conditions and disabilities.
‘This strange little palaeoniscid': a new early actinopterygian genus, and commentary on pectoral fin conditions and function
Authors: COATES Michael I. , TIETJEN Kristen
Published: November 2018

The early actinopterygianMesopoma plantiis reassigned to a new genus on the basis of data obtained from high-resolution computed tomography (CT) scans of an unusually well-preserved specimen from the Early Pennsylvanian of Lancashire, UK. The formerM. plantiis joined by two furtherMesopomaspecies from the Late Mississippian of Scotland. CT scans of the keyplantispecimen bring to light new details of the dermal skull, pectoral girdle and fin. Among the cranial features, CT data reveal a specialised, anteriorly projecting preopercular bone, the location of the spiracular duct opening, presence of a so-called coronoid process on the lower jaw and the full three-dimensional shape of the snout. Of the pectoral girdle and fin, for the first time in a Palaeozoic actinopterygian it has been possible to complete a three-dimensional reconstruction of the entire endoskeleton in articulation. The fin presents new diversity within a conservative general pattern, revealing for the first time a double propterygium. Girdle shape shows that the fin orientation is derived: rotated with the leading edge dorsalmost. These details are used to identify unexploited character states for use in phylogenetic analyses, while functional implications of the fin and girdle suggest advanced locomotory control emerging among different groups of post-Devonian ray-finned fishes.
Ultrasound and contrast enhanced ultrasound imaging in the diagnosis of acute aortic pathologies
Authors: Negrão de Figueiredo Giovanna , Müller-Peltzer Katharina , Schwarze Vincent , Rübenthaler Johannes , Clevert Dirk-André
Published: November 2018

Abstract. Conventional ultrasound is worldwide the first-line imaging modality for the prompt diagnosis in the daily practice because it is a cost-effective and easy to perform technique. The additional application of contrast media has been used to enhance the intravascular contrast and to improve the imaging diagnostic accuracy in the detection, classification and follow-up of vascular pathologies. Contrast-enhanced ultrasound has the advantage of being a safe, fast and dynamic non-invasive imaging tool with excellent results in the diagnosis of acute aortic pathologies, especially the detection of endoleaks after endovascular aneurysm repair. This review describes the diagnostic and therapeutic roles of ultrasound and contrast-enhanced ultrasound imaging in the most common vascular pathologies such as aortic dissections, aneurysms and endoleaks.

Keywords: Endoleak, contrast media, ultrasonography, aorta
The Identity Status Continuum Revisited
Authors: Meeus Wim
Published: November 2018

Abstract. The developmental continuum of identity status has been a topic of theoretical debate since the early 1980’s. A recent meta-analysis and recent studies with dual cycle models lead to two conclusions: (1) during adolescence there is systematic identity maturation; (2) there are two continuums of identity status progression. Both continuums show that in general adolescents move from transient identity statuses to identity statuses that mark the relative endpoints of development: from diffusion to closure, and from searching moratorium and moratorium to closure and achievement. This pattern can be framed as development from identity formation to identity maintenance. In Identity Status Interview research using Marcia’s model, not the slightest indication for a continuum of identity development was found. This may be due to the small sample sizes of the various studies leading to small statistical power to detect differences in identity status transitions, as well as developmental inconsistencies in Marcia’s model. Findings from this review are interpreted in terms of life-span developmental psychology.
An ultra-compact integrated system for brain activity recording and stimulation validated over cortical slow oscillations in vivo and in vitro
Authors: Pazzini Luca , Polese Davide , Weinert Julia F. , Maiolo Luca , Maita Francesco , Marrani Marco , Pecora Alessandro , Sanchez-Vives Maria V. , Fortunato Guglielmo
Published: November 2018

The understanding of brain processing requires monitoring and exogenous modulation of neuronal ensembles. To this end, it is critical to implement equipment that ideally provides highly accurate, low latency recording and stimulation capabilities, that is functional for different experimental preparations and that is highly compact and mobile. To address these requirements, we designed a small ultra-flexible multielectrode array and combined it with an ultra-compact electronic system. The device consists of a polyimide microelectrode array (8 µm thick and with electrodes measuring as low as 10 µm in diameter) connected to a miniaturized electronic board capable of amplifying, filtering and digitalizing neural signals and, in addition, of stimulating brain tissue. To evaluate the system, we recorded slow oscillations generated in the cerebral cortex network both from in vitro slices and from in vivo anesthetized animals, and we modulated the oscillatory pattern by means of electrical and visual stimulation. Finally, we established a preliminary closed-loop algorithm in vitro that exploits the low latency of the electronics (<0.5 ms), thus allowing monitoring and modulating emergent cortical activity in real time to a desired target oscillatory frequency.
Efficient immunoaffinity chromatography of lymphocytes directly from whole blood
Authors: Mohr Fabian , Przibilla Sabine , Leonhardt Franziska , Stemberger Christian , Dreher Stefan , Müller Thomas R. , Fräßle Simon P. , Schmidt Georg P. , Kiene Marie-Luise , Stadler Herbert , Busch Dirk H.
Published: November 2018

We show that defined lymphocytes can be rapidly purified by immunoaffinity chromatography starting directly from whole blood. The method relies on low-affinity Fab-fragments attached to a column-matrix combined with the reversible Strep-tag technology. Compared to established cell enrichment protocols, the Strep-tag affinity chromatography of cells is independent of erythrocyte lysis or centrifugation steps, allowing for simple cell-enrichment with good yields, high purities, and excellent functionality of purified cells.
Electrospun nerve guide conduits have the potential to bridge peripheral nerve injuries in vivo
Authors: Frost Hanna K. , Andersson Tomas , Johansson Sebastian , Englund-Johansson U. , Ekström Per , Dahlin Lars B. , Johansson Fredrik
Published: November 2018

Electrospinning can be used to mimic the architecture of an acellular nerve graft, combining microfibers for guidance, and pores for cellular infiltration. We made electrospun nerve guides, from polycaprolactone (PCL) or poly-L-lactic acid (PLLA), with aligned fibers along the insides of the channels and random fibers around them. We bridged a 10 mm rat sciatic nerve defect with the guides, and, in selected groups, added a cell transplant derived from autologous stromal vascular fraction (SVF). For control, we compared to hollow silicone tubes; or autologous nerve grafts. PCL nerve guides had a high degree of autotomy (8/43 rats), a negative indicator with respect to future usefulness, while PLLA supported axonal regeneration, but did not outperform autologous nerve grafts. Transplanted cells survived in the PLLA nerve guides, but axonal regeneration was not enhanced as compared to nerve guides alone. The inflammatory response was partially enhanced by the transplanted cells in PLLA nerve grafts; Schwann cells were poorly distributed compared to nerve guide without cells. Tailor-made electrospun nerve guides support axonal regeneration in vivo, and can act as vehicles for co-transplanted cells. Our results motivate further studies exploring novel nerve guides and the effect of stromal cell-derived factors on nerve generation.
Somatic alterations compromised molecular diagnosis of DOCK8 hyper-IgE syndrome caused by a novel intronic splice site mutation
Authors: Hagl Beate , Spielberger Benedikt D. , Thoene Silvia , Bonnal Sophie , Mertes Christian , Winter Christof , Nijman Isaac J. , Verduin Shira , Eberherr Andreas C. , Puel Anne , Schindler Detlev , Ruland Jürgen , Meitinger Thomas , Gagneur Julien , Orange Jordan S. , van Gijn Marielle E. , Renner Ellen D.
Published: November 2018

In hyper-IgE syndromes (HIES), a group of primary immunodeficiencies clinically overlapping with atopic dermatitis, early diagnosis is crucial to initiate appropriate therapy and prevent irreversible complications. Identification of underlying gene defects such as in DOCK8 and STAT3 and corresponding molecular testing has improved diagnosis. Yet, in a child and her newborn sibling with HIES phenotype molecular diagnosis was misleading. Extensive analyses driven by the clinical phenotype identified an intronic homozygous DOCK8 variant c.4626 + 76 A > G creating a novel splice site as disease-causing. While the affected newborn carrying the homozygous variant had no expression of DOCK8 protein, in the index patient molecular diagnosis was compromised due to expression of altered and wildtype DOCK8 transcripts and DOCK8 protein as well as defective STAT3 signaling. Sanger sequencing of lymphocyte subsets revealed that somatic alterations and reversions revoked the predominance of the novel over the canonical splice site in the index patient explaining DOCK8 protein expression, whereas defective STAT3 responses in the index patient were explained by a T cell phenotype skewed towards central and effector memory T cells. Hence, somatic alterations and skewed immune cell phenotypes due to selective pressure may compromise molecular diagnosis and need to be considered with unexpected clinical and molecular findings.
Overlooked Trends in Observed Global Annual Precipitation Reveal Underestimated Risks
Authors: Lausier Anne M. , Jain Shaleen
Published: November 2018

Numerous human and environmental systems are sensitive to the spatial and temporal distribution of precipitation, including agriculture, water supply, and ecosystems. Trends in observed precipitation form an important line of evidence to understand how changes may increase system vulnerabilities. Linear trends reported in US and global climate assessments reflect changes in mean annual precipitation. Mean trends may not reflect changes across other quantiles in the precipitation probability distribution, including the tails (very high and low precipitation levels), leading to systematic mischaracterization of climate risk. Here we reanalyze global annual precipitation using quantile regression to reveal overlooked trends. We find trends in the tails inconsistent with the mean in 44.4% of land area and 40.7% of rainfed agricultural regions. Previously undetected trends offer a more accurate view of the changing climate. This work enables reappraisals of risk aggregated over thresholds in human and environmental systems, enabling revaluation of threats and identification of appropriate adaptation strategies.
The effect of cell penetrating peptide-conjugated coactivator-associated arginine methyltransferase 1 (CPP-CARM1) on the cloned mouse embryonic development
Authors: Bang Jae-Il , Lee Eun-Hye , Lee Ah Reum , Il Lee Jin , Choi Seo Hye , Seol Dong-Won , Park Chang-Hwan , Lee Dong Ryul
Published: November 2018

Abnormalities in gene expression that negatively affect embryonic development are frequently observed in cloned embryos generated by somatic cell nuclear transfer (SCNT). In the present study, we successfully produced a cell-penetrating peptide (CPP)-conjugated with coactivator-associated arginine methyltransferase 1 (CARM1) protein from mammalian cells and confirmed introduction into donor somatic cells and cloned 8-cell embryos within 3 hours after addition to culture medium. In addition, H3R17 dimethylation and embryonic development up to the blastocyst stage were increased in the group treated with exogenous CPP-CARM1 protein compared with the untreated group (control). Interestingly, the number of total cells and trophectoderm in blastocysts as well as implantation rate were significantly increased in the CPP-CARM1 protein-treated group. However, the cell number of inner cell mass (ICM) was not changed compared with the control group; similarly, expression of pluripotency-related genes Oct4 and Nanog (ICM markers) was not significantly different between groups. On the other hand, expression of the implantation-related gene Cdx2 (trophectoderm marker) was transiently increased after treatment with CPP-CARM1 protein. On the basis of these results, we conclude that supplementation with exogenous CPP-CARM1 protein improves embryonic development of cloned embryos through regulation of histone methylation and gene expression. In addition, our results suggest that CPP-CARM1 protein may be a useful tool for strengthening implantation of mammalian embryos.
ME1 promotes basal-like breast cancer progression and associates with poor prognosis
Authors: Liao Ruocen , Ren Guoping , Liu Huixin , Chen Xingyu , Cao Qianhua , Wu Xuebiao , Li Jun , Dong Chenfang
Published: November 2018

Basal-like breast cancer (BLBC) is associated with a poor clinical outcome due to the few treatment options and absence of effective targeted agents. Here, we show that malic enzyme 1 (ME1) is dramatically upregulated in BLBC due to ME1 copy number amplification. ME1 expression increases glucose uptake and lactate production, and reduces oxygen consumption, leading to aerobic glycolysis. ME1 expression promotes, whereas knockdown of ME1 expression suppresses tumorigenicity. In breast cancer patients, ME1 expression is positively correlated with large tumor size, high grade, poor survival, and chemotherapy resistance. Our study not only contributes to a new understanding of how metabolic reprogramming contributes to BLBC progression, but also provides a potential prognostic marker and therapeutic target for this challenging disease.
Calpain-mediated tau fragmentation is altered in Alzheimer’s disease progression
Authors: Chen Hsu-Hsin , Liu Peter , Auger Paul , Lee Seung-Hye , Adolfsson Oskar , Rey-Bellet Lorianne , Lafrance-Vanasse Julien , Friedman Brad A. , Pihlgren Maria , Muhs Andreas , Pfeifer Andrea , Ernst James , Ayalon Gai , Wildsmith Kristin R. , Beach Thomas G. , van der Brug Marcel P.
Published: November 2018

The aggregation of intracellular tau protein is a major hallmark of Alzheimer’s disease (AD). The extent and the stereotypical spread of tau pathology in the AD brain are correlated with cognitive decline during disease progression. Here we present an in-depth analysis of endogenous tau fragmentation in a well-characterized cohort of AD and age-matched control subjects. Using protein mass spectrometry and Edman degradation to interrogate endogenous tau fragments in the human brain, we identified two novel proteolytic sites, G323 and G326, as major tau cleavage events in both normal and AD cortex. These sites are located within the sequence recently identified as the structural core of tau protofilaments, suggesting an inhibitory mechanism of fibril formation. In contrast, a different set of novel cleavages showed a distinct increase in late stage AD. These disease-associated sites are located outside of the protofilament core sequence. We demonstrate that calpain 1 specifically cleaves at both the normal and diseased sites in vitro, and the site selection is conformation-dependent. Monomeric tau is predominantly cleaved at G323/G326 (normal sites), whereas oligomerization increases cleavages at the late-AD-associated sites. The fragmentation patterns specific to disease and healthy states suggest novel regulatory mechanisms of tau aggregation in the human brain.
Luminescence lifetime encoding in time-domain flow cytometry
Authors: Kage Daniel , Hoffmann Katrin , Wittkamp Marc , Ameskamp Jens , Göhde Wolfgang , Resch-Genger Ute
Published: November 2018

Time-resolved flow cytometry represents an alternative to commonly applied spectral or intensity multiplexing in bioanalytics. At present, the vast majority of the reports on this topic focuses on phase-domain techniques and specific applications. In this report, we present a flow cytometry platform with time-resolved detection based on a compact setup and straightforward time-domain measurements utilizing lifetime-encoded beads with lifetimes in the nanosecond range. We provide general assessment of time-domain flow cytometry and discuss the concept of this platform to address achievable resolution limits, data analysis, and requirements on suitable encoding dyes. Experimental data are complemented by numerical calculations on photon count numbers and impact of noise and measurement time on the obtained lifetime values.
High Oxygen Exchange to Music Indicates Auditory Distractibility in Acquired Brain Injury: An fNIRS Study with a Vector-Based Phase Analysis
Authors: Jeong Eunju , Ryu Hokyoung , Shin Joon-Ho , Kwon Gyu Hyun , Jo Geonsang , Lee Ji-Yeong
Published: November 2018

Attention deficits due to auditory distractibility are pervasive among patients with acquired brain injury (ABI). It remains unclear, however, whether attention deficits following ABI specific to auditory modality are associated with altered haemodynamic responses. Here, we examined cerebral haemodynamic changes using functional near-infrared spectroscopy combined with a topological vector-based analysis method. A total of thirty-seven participants (22 healthy adults, 15 patients with ABI) performed a melodic contour identification task (CIT) that simulates auditory distractibility. Findings demonstrated that the melodic CIT was able to detect auditory distractibility in patients with ABI. The rate-corrected score showed that the ABI group performed significantly worse than the non-ABI group in both CIT1 (target contour identification against environmental sounds) and CIT2 (target contour identification against target-like distraction). Phase-associated response intensity during the CITs was greater in the ABI group than in the non-ABI group. Moreover, there existed a significant interaction effect in the left dorsolateral prefrontal cortex (DLPFC) during CIT1 and CIT2. These findings indicated that stronger hemodynamic responses involving oxygen exchange in the left DLPFC can serve as a biomarker for evaluating and monitoring auditory distractibility, which could potentially lead to the discovery of the underlying mechanism that causes auditory attention deficits in patients with ABI.
Hepatokine α1-Microglobulin Signaling Exacerbates Inflammation and Disturbs Fibrotic Repair in Mouse Myocardial Infarction
Authors: Hakuno Daihiko , Kimura Masahiro , Ito Shinji , Satoh Junko , Nakashima Yasuhiro , Horie Takahiro , Kuwabara Yasuhide , Nishiga Masataka , Ide Yuya , Baba Osamu , Nishi Hitoo , Nakao Tetsushi , Nishino Tomohiro , Nakazeki Fumiko , Koyama Satoshi , Hanada Ritsuko , Randolph Ruiz R. , Endo Jin , Kimura Takeshi , Ono Koh
Published: November 2018

Acute cardiac rupture and adverse left ventricular (LV) remodeling causing heart failure are serious complications of acute myocardial infarction (MI). While cardio-hepatic interactions have been recognized, their role in MI remains unknown. We treated cultured cardiomyocytes with conditioned media from various cell types and analyzed the media by mass spectrometry to identify α1-microglobulin (AM) as an Akt-activating hepatokine. In mouse MI model, AM protein transiently distributed in the infarct and border zones during the acute phase, reflecting infiltration of AM-bound macrophages. AM stimulation activated Akt, NFκB, and ERK signaling and enhanced inflammation as well as macrophage migration and polarization, while inhibited fibrogenesis-related mRNA expression in cultured macrophages and cardiac fibroblasts. Intramyocardial AM administration exacerbated macrophage infiltration, inflammation, and matrix metalloproteinase 9 mRNA expression in the infarct and border zones, whereas disturbed fibrotic repair, then provoked acute cardiac rupture in MI. Shotgun proteomics and lipid pull-down analysis found that AM partly binds to phosphatidic acid (PA) for its signaling and function. Furthermore, systemic delivery of a selective inhibitor of diacylglycerol kinase α-mediated PA synthesis notably reduced macrophage infiltration, inflammation, matrix metalloproteinase activity, and adverse LV remodeling in MI. Therefore, targeting AM signaling could be a novel pharmacological option to mitigate adverse LV remodeling in MI.
Publisher Correction: Longitudinal analysis of biomarker data from a personalized nutrition platform in healthy subjects
Authors: Westerman Kenneth , Reaver Ashley , Roy Catherine , Ploch Margaret , Sharoni Erin , Nogal Bartek , Sinclair David A. , Katz David L. , Blumberg Jeffrey B. , Blander Gil
Published: November 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
“Receptor free” inner filter effect based universal sensors for nitroexplosive picric acid using two polyfluorene derivatives in the solution and solid states
Authors: Tanwar Arvin Sain , Patidar Sourabh , Ahirwar Saurabh , Dehingia Sourav , Iyer Parameswar Krishnan
Published: November 2018

“Receptor free” and “interaction free” detection of nitroexplosive PA at remarkably low limit of detection (LOD) values of 110 nM and 219 nM using two new fluorescent polymersviathe inner filter effect mechanism.
Isolation and characterization of a high-spin mixed-valent iron dinitrogen complex
Authors: McWilliams Sean F. , Bunting Philip C. , Kathiresan Venkatesan , Mercado Brandon Q. , Hoffman Brian M. , Long Jeffrey R. , Holland Patrick L.
Published: November 2018

A new mixed-valence iron–dinitrogen complex has localized valence by IR and Mossbauer spectroscopies, and slow magnetic relaxation.
Interfacial premelting of ice in nano composite materials
Authors: Li Hailong , Bier Markus , Mars Julian , Weiss Henning , Dippel Ann-Christin , Gutowski Olof , Honkimäki Veijo , Mezger Markus
Published: November 2018

We present a quantitative description of ice premelting in permafrost model systems. Experimental data on the interfacial premelting in ice/clay nano composites was obtained by high energy X-ray diffraction.
Carbon nanotubes-ferrite-manganese dioxide micromotors for advanced oxidation processes in water treatment
Authors: Maria-Hormigos Roberto , Pacheco Marta , Jurado-Sánchez Beatriz , Escarpa Alberto
Published: November 2018

Multifunctional SW-Fe2O3/MnO2 tubular micromotors are used for ‘on-the-fly’ advanced water oxidation of industrial organic pollutants.
Multifunctional metal organic framework and carbon nanotube-modified filter for combined ultrafine dust capture and SO2 dynamic adsorption
Authors: Feng Shasha , Li Xingya , Zhao Shuaifei , Hu Yaoxin , Zhong Zhaoxiang , Xing Weihong , Wang Huanting
Published: November 2018

Ultrafine dust and acid polar gas species (SO2, NOx, H2S, etc.) in the atmosphere have severe effects on human health.
The role of a plasmonic substrate on the enhancement and spatial resolution of tip-enhanced Raman scattering
Authors: Rahaman Mahfujur , Milekhin Alexander G. , Mukherjee Ashutosh , Rodyakina Ekaterina E. , Latyshev Alexander V. , Dzhagan Volodymyr M. , Zahn Dietrich R. T.
Published: November 2018

We look to understand the enhancement and spatial resolution of a tip-enhanced Raman scattering (TERS) system containing a metal tip and plasmonic substrate.
Inhibition of perilipin 2 expression reduces pro-inflammatory gene expression and increases lipid droplet size
Authors: Norman Jennifer E. , Aung Hnin H. , Wilson Dennis W. , Rutledge John C.
Published: November 2018

Reduced perilipin 2 expression modifies the response of THP-1 monocytes to TGRL lipolysis product exposure.
Radical polymerization of biobased monomers in aqueous dispersed media
Authors: Molina-Gutiérrez Samantha , Ladmiral Vincent , Bongiovanni Roberta , Caillol Sylvain , Lacroix-Desmazes Patrick
Published: November 2018

This review highlights the synthesis of biobased monomers from renewable resources for the preparation of polymers by (mini)emulsion and suspension polymerizations.
Visible-light-enabled aerobic synthesis of benzoin bis-ethers from alkynes and alcohols
Authors: Lei Wen-Long , Yang Biao , Zhang Qing-Bao , Yuan Pan-Feng , Wu Li-Zhu , Liu Qiang
Published: November 2018

The first visible-light enabled metal-free aerobic protocol for one-pot synthesis of benzoin bis-ethers from alkenes and alcohols has been developed at room temperature.
Synthesis of spiropyrrolidine oxindolesviaAg-catalyzed stereo- and regioselective 1,3-dipolar cycloaddition of indole-based azomethine ylides with chalcones
Authors: Yue Guizhou , Wu Yao , Dou Zhengjie , Chen Huabao , Yin Zhongqiong , Song Xu , He ChangLiang , Wang Xianxiang , Feng Juhua , Zhang Zuming , Zou Ping , Lu Cuifen
Published: November 2018

In excess of 100 new compounds were prepared in moderate to high yields (50–95%) with good to excellent diastereoselectivity (11 : 1 → 20 : 1 dr) by Ag-catalyzed 1,3-dipolar cycloaddition.
Proteomic analysis of RAW macrophages treated with cGAMP or c-di-GMP reveals differentially activated cellular pathways
Authors: Sooreshjani Moloud Aflaki , Gursoy Ulvi K. , Aryal Uma K. , Sintim Herman O.
Published: November 2018

cGAMP modulates proteins involved in antigen presentation and inflammation.
Polyethylene glycol-doped BiZn2VO6as a high-efficiency solar-light-activated photocatalyst with substantial durability toward photodegradation of organic contaminations
Authors: Pirhashemi Mahsa , Elhag Sami , Habibi-Yangjeh Aziz , Pozina Galia , Willander Magnus , Nur Omer
Published: November 2018

In this study, we focus on a simple, low-priced, and mild condition hydrothermal route to construct BiZn2VO6nanocompounds (NCs) as a novel photocatalyst with strong solar light absorption ability for environmental purification.
Isolation and evaluation of two angiotensin-I-converting enzyme inhibitory peptides from fermented grains (Jiupei) used in Chinese Baijiu production
Authors: Zhang Limo , Jiang Yunsong , Yin Zhongtian , Sun Jinyuan , Li Hehe , Sun Xiaotao , Huang Mingquan , Zheng Fuping
Published: November 2018

Two tripeptides with ACE inhibitory activity were isolated from Jiupei (the raw material of Baijiu) distillation.
Network elasticity of a model hydrogel as a function of swelling ratio: from shrinking to extreme swelling states
Authors: Hoshino Ken-ichi , Nakajima Tasuku , Matsuda Takahiro , Sakai Takamasa , Gong Jian Ping
Published: November 2018

Elasticity of a model polymer gel has been systematically investigated up to its upper swelling limit both experimentally and theoretically.
Droplet impact on heated powder bed
Authors: Liu Dongdong , Tan Hong-Wei , Tran Tuan
Published: November 2018

The impact of droplets on a heated powder bed involves a wide range of phenomena with increasing complexity, from spreading of liquid, to bubble nucleation, to more complex ones such as splashing, crater formation, and fluidization.
GLE events in 24th solar cycle
Authors: Balabin Yury , Gvozdevsky Boris , Germanenko Aleksei , Maurchev Eugeny
Published: November 2018

Started in 2009, the 24th solar cycle is going to end. In 2015, the solar activity was at its maximum, turning down. According to many indices, this cycle turned out to be abnormal. For instance, in the previous, the 23rd cycle, the index such as the number of solar spots was as high as 175, compared with that of the 24th cycle, not exceeding 100. According to the number of GLE-events (ground level enhancement of solar cosmic rays, observed on neutron monitors), the current cycle also differs greatly from the previous ones. In the 23rd cycle, the number of great GLE-events was as high as four, and that of small and moderate being five. In the 24th cycle, only two GLE-events were recorded: GLE 71 (17.05.2012) и GLE 72 (10.09.2017), with the last event being of small amplitude (5%). The presence of the neutron monitors network data enables calculation of the energy spectrum and other parameters of solar cosmic rays. The GLEevents are processed by special technique developed at PGI. It is aimed at solving the inverse problem: based on the data from the world neutron monitors network, to obtain the parameters of solar cosmic rays energy spectra. Like the previous ones, GLE-events 71 and 72 were processed by this technique. The energetic spectra obtained were compared with those in other events of the previous cycles
Global response of Magnetic field and Ionosonde observations to intense solar flares on 6 and 10 September 2017
Authors: Fujimoto Akiko , Yoshikawa Akimasa , Ikeda Akihiro
Published: November 2018

Intense X-ray fluxes during solar flares are known to cause enhanced ionization in the Earth’s ionospheric D, E and F region. This sudden change of ionospheric electron density profile is serious problem to radio wave communication and navigation system. The ground magnetograms often record the sudden change in the sunlit hemisphere during the enhanced X-ray flux, due to the sudden increase in the global ionospheric current system caused by the flare-induced enhanced ionospheric conductivity. These geomagnetic field disturbances are known as ‘‘solar flare effects’’ (SFEs) or geomagnetic crochets [Campbell, 2003]. The typical SFE is increase variation on the equatorial magnetic data. On Ionosonde observation during solar flare event, the High-Frequency (HF) radio wave blackout is often detected in ionogram due to the sudden disturbance in ionosphere. Two intense X-class solar flares occurred on 6 and 10 September 2017. We investigated the magnetic field and Ionosonde responses to the intense solar flare events. Dayside magnetic field variations sudden increased due to the ionospheric disturbance resulting from solar flare. There is no response in night side magnetometer data. The magnitude of SFE (magnetic field) is independent of solar flare x-ray magnitude. We found HF radio wave blackout in ionogram at dayside Ionosonde stations. The duration of blackout is dependent of latitude and local time of Ionosonde stations. There is the different feature of ionogram at night side.
Resonant scattering by excited ions as an indicator of the precipitation of charged particles into the atmosphere
Authors: Bychkov Vasily , Perezhogin Andrey , Seredkin Ilya
Published: November 2018

The results of two-frequency lidar sounding of the atmosphere from the altitudes of 100-500 km are presented. The data were obtained in 2017 at a lidar site located in Kamchatka. One lidar channel is applied to investigate the aerosol formations in the middle atmosphere and to issue the resonance scattering on excited ions of atomic nitrogen in the upper atmosphere. Nd:YAG laser operating on the wavelength of 532 nm is used in this channel. A dye laser with tunable frequency is applied in the second channel. The wavelength of 561.1 nm corresponds to the chosen dipole transition between the excited states of atomic oxygen. Defined light-scattering layers were discovered in the region of 200-400 km. They are caused by presence of excited states of atomic oxygen and nitrogen ions.

The possibility of reconstruction of excited ions Nh-profile and determination of precipitated electron fluxes spectra by the lidar method is shown. The possibility of manifesting resonance scattering and formation of imaginary aerosol layers in the middle atmosphere is discussed.
Schumann resonance parameters at Kuju station during solar flares
Authors: Ikeda Akihiro , Uozumi Teiji , Yoshikawa Akimasa , Fujimoto Akiko , Abe Shuji
Published: November 2018

We examined the Schumann resonance (SR) at low-latitude station KUJ by comparing with solar X-ray flux and solar proton flux at a geostationary orbit. For intense solar activity in October-November 2003, the reaction of the SR frequency to X-ray enhancement and SPEs was different. The SR frequency in H component increased at the time of the Xray enhancement. The response of SR seems to be caused by the increase of the electron density in the ionospheric D region which ionized by the enhanced solar X-ray flux. In the case of the SPEs, the SR frequency in D component decreased with enhancement of solar proton flux. We suggest that the SPEs caused the decrease of altitude on the ionopheric D region at high-latitude region, and the SR frequency decreased.
Study of cyclone effect in Kamchatka on electron distribution in the ionosphere by satellite tomography in the conditions of low seismicity
Authors: Bogdanov Vadim
Published: November 2018

The paper presents the results of investigation of cyclone possible effect on ionosphere parameters. Monitoring of ionosphere state has been carried out by automatic sounding applying low orbital navigational spacecrafts in the conditions of low seismicity. Receiving stations were locating in meridian direction of Kamchatka peninsula in Paratunka, Mil’kovo and Esso villages. It has been shown that during nighttime cyclone passage (according to local time) on 18.01., 03.02. and 17.02.2013 over Kamchatka, synchronous increase of electron concentration occurred in the region over its epicenter in comparison to the next days without cyclones. With the increase of the latitude, i.e. further from the center of the cyclone, electron concentration decreased in comparison to calm days.
Analysis of the ionospheric parameter dynamics on the basis of a generalized multicomponent model
Authors: Mandrikova Oksana , Fetisova Nadezhda , Polozov Yuryi , Geppener Vladimir
Published: November 2018

In the present paper, we have carried out an analysis of the ionospheric critical frequency data of the F2 layer during strong magnetic storms in 2017-2018. The ionospheric data of Paratunka (IKIR FEB RAS, Kamchatka, 53.0 N, 158.7 E), Wakkanai (Japan, 45.16 N, 141.75 E), and Moscow stations (Russia, 55.49 N, 37.29 E) were used. The study was carried out using a generalized multicomponent model (GMCM) developed by the authors. GMCM allows studying the dynamics of the ionospheric parameters in detail and estimating their characteristics. Using the modeling, we detected and studied anomalous changes in the ionosphere preceding and accompanying the periods of magnetic storms in the analyzed areas. The study results were compared with the traditional median method and showed the perspectiveness of GMCM. The research is supported by a grant from the Russian Science Foundation (project No. 14-11-00194).
Fluctuations and nonlinear oscillations in complex natural systems
Authors: Shevtsov Boris , Shevtsova Olga
Published: November 2018

Resonance propagation of radiation in the ionosphere, solar activity, magnetic dynamos, lightning discharges, fracture processes, plastic deformations, seismicity, turbulence and hydrochemical variability are considered as examples of complex dynamical systems in which similar fluctuation and nonlinear oscillation regimes arise. Collective effects in the systems behavior and chaotic oscillations in individual subsystems, the ratio of random and deterministic, the analysis of variability factors and the change of dynamic regimes, the scaling relation between the elements of the system and the interaction of scales are discussed. It is shown that consolidation and branching in disruptions or thunderstorm activity is the transfer of disturbances to up and down of cascades as in turbulence, and the alpha-omega effects of the magnetic dynamo are the same cascade processes, but in the presence of an external magnetic field or rotation that removes the degeneracy in the system by directions. Particular attention is paid to natural generators and oscillation amplifiers, in which the Lorentz triplet plays the role of a universal model of a nonlinear oscillator.
Influence of solar and geomagnetic storms on terrestrial photosynthesis
Authors: Rodríguez-López Lien , González-Rodríguez Lisdelys , Peñate-Alvariño Liuba , Cardenas Rolando , Parra Oscar
Published: November 2018

It is reviewed the potential influence of solar and geomagnetic storms on terrestrial photosynthesis. Then it is presented a modification of a physical-mathematical model of photosynthesis published by some of us, which allows quantifying the influence of particulate ionizing radiation on this biological process. Some guidelines to obtain this new model from first principles are mentioned and it is applied to some case studies including atmospheric and geomagnetic perturbation due to solar storms.
The Lorenz system and its generalizations as dynamo models with memory
Authors: Vodinchar Gleb , Kazakov Evgeny
Published: November 2018

The one of the known applications of the classical Lorenz system is an axisymmetric αω-dynamo with a dynamical quenching of the α-effect by the helicity. In this paper we consider generalizations of the Lorentz system, which are the models of α2 - and α2ω-dynamo. The cases of finite and infinite memory in the quenching functional are considered. The conditions for the existence of stationary dynamo regimes and regimes of regular and chaotic inversions are analytically and numerically studded.
Modernization of adaptive matching pursuit method to analyze geophysical signals of pulse nature
Authors: Lukovenkova Ol’ga , Marapulets Yuriy , Tristanov Aleksandr , Kim Alina
Published: November 2018

The paper is devoted to the development and comparison of different numerical methods which increase the adaptive property and improve the accuracy of matching pursuit algorithm in connection to geoacoustic and electromagnetic signals. At each step of adaptive matching pursuit, a function is chosen which has the highest correlation with an initial signal. Then parameters of a chosen function are refined. The refinement is performed by the help of different grid methods and methods based on gradient direction search. The paper considers the peculiarities of application of sparse approximation methods to geophysical signals of pulse nature and compares different variants of modification of adaptive matching pursuit algorithm.
Methods for spatial direction finding of geoacoustic signals at Mikizha Lake in Kamchatka
Authors: Shcherbina Albert , Solodchuk Alexandra
Published: November 2018

In the framework of the work, a spatial analysis of geoacoustic emissions properties recorded by a hydroacoustic receiver in a shallow Mikizha Lake, Kamchatkskiy kray, is carried out. The features of geoacoustic pulse registration are considered, methods to determine the directions of their arrival and to locate the sources are proposed. Examples of geoacoustic signals during background periods and seismic event preparation periods are presented.
Shock-wave model of the earthquake and Poincaré quantum theorem give an insight into the aftershock physics.
Authors: Kuznetsov Vladimir
Published: November 2018

A fundamentally new model of aftershocks evident from the shock-wave model of the earthquake and Poincaré Recurrence Theorem [H. Poincare, Acta Mathematica 13, 1 (1890)] is proposed here. The authors (Recurrences in an isolated quantum many-body system, Science 2018) argue that the theorem should be formulated as “Complex systems return almost exactly into their initial state”. For the first time, this recurrence theorem has been demonstrated with complex quantum multi-particle systems. Our shock-wave model of an earthquake proceeds from the quantum entanglement of protons in hydrogen bonds of lithosphere material. Clearly aftershocks are quantum phenomena which mechanism follows the recurrence theorem.
Applying of depth-averaged hydrodynamic modeling with different methods of turbulence closure for flow near channel groyne. Part I – hydrodynamic background
Authors: Ewertowski Ryszard
Published: November 2018

Training structures in flow stream play an important role in shaping flow and bed properties. Planning to introduce such training elements like groins or dikes into the river stream one need to know consequences they may introduce into flow field and bed shear stresses. These consequences can be investigated by laboratory experiments on hydraulic models or by numerical modelling using hydrodynamic simulation models. In the paper the second possibility is exploited by applying two-dimensional depth-averaged model for straight rectangular channel with a groyne. This paper contains the first part of the research results and it describes hydrodynamic background of the flow phenomenon, concentrating on hydrodynamic equations for depth-averaged flow, types of eddy viscosity method used and kind of boundary conditions applied. Based on the hydrodynamic descriptions, different simulation experiments have been conducted for the flow problem and the whole analysis of simulation results for flow in channel near groyne is contained in the second part of the research activity (Part II = Analysis of simulation).
Strategy for Multidimensional Peatland Ecosystem Analysis in the Context of the Atmospheric Properties
Authors: Harenda Kamila M. , Poczta Patryk , Szczepanik Dominika , Wang Dongxiang , Stachlewska Iwona S. , Chojnicki Bogdan H.
Published: November 2018

There is the need of integration of atmospheric and ecosystem research in order to assess the habitats reaction in the future since the recent climate changes. Peatlands due to their vulnerability are important ecosystems since their strong interaction with the climate system. In stable climatic conditions, they are atmospheric carbon sinks. The study of the atmosphere properties in the context of peatlands productivity requires the application of the multidimensional strategy of field measurements. These kind of measurements are conducted using the following sensors: sun photometer, cloud radar, Raman lidar and eddy covariance (EC) system. They are located and operated at the Rzecin peatland in the framework of the POLIMOS project. So far, aerosols presence in the air was found as a factor that increases the peatland production. This presents the novel strategy of extensive atmospheric studies in order to identify the selected particles type impact on peatlands carbon uptake capabilities.
Monthly average daily diffuse solar radiation in Poland within the period 2005–2015
Authors: Kleniewska Małgorzata , Mitrowska Dorota , Chojnicki Bogdan H.
Published: November 2018

In this paper an 11-year series of daily values of diffuse solar radiation registered at 8 actinometric stations in Poland was used to describe the characteristics of diffuse radiation and diffuse fraction of global radiation for the area of Poland. Based on the monthly average daily diffuse, global and extraterrestrial solar radiation a linear relationship between these elements was determined. The obtained equation enables the calculation of the monthly average daily diffuse solar radiation for Poland and the application of its values to further climatology studies.