bluuebunny/crossref_metadata_2025 huggingface dataset:
Bond performance between recycled concrete and steel bar after high temperature
Authors: Wang Qihao , Wang Ting , Zhou Xiaoyu , Chen Qunyu
Published: March 2023

To investigate the influence of high temperatures on the bond performance of recycled concrete and steel bar, this article considers the influence of different concrete types (ordinary concrete and recycled concrete) and different temperatures (20, 100, 150, 200, 250, and 300°C) on the concrete compressive strength and the bond performance of concrete and steel bar. On this basis, the calculation formula of bond strength and bond slip between concrete and steel bar after the high temperature is established. The test results show that the concrete compressive strength presents a downward trend with the increase in temperature; the compressive strength loss of recycled concrete is higher than that of ordinary concrete; when the temperature reached 300°C, the compressive strength loss of ordinary concrete is 24.4%, while that of recycled concrete is 41.6%. The bond strength of pull-out specimens decreases with the increase of temperature, while the bond slip increases with the increase of temperature; the bond strength between recycled concrete and steel bar is lower than that between ordinary concrete and steel bar, while the bond slip between recycled concrete and steel bar is higher than that between ordinary concrete and steel bar. This article can provide a theoretical basis for the application of recycled concrete in high-temperature environment.
Mechanistic aspect for the atom transfer radical polymerization of itaconimide monomers with methyl methacrylate: a computational study
Authors: Deoghare Chetana
Published: March 2023

Atom transfer radical polymerization (ATRP) is a versatile & famous technique for the synthesis of well defined molecular architectures. In ATRP, there is a dynamic equilibrium exists between active & dormant species. Therefore, ATRP progress through a sequence of activation & deactivation cycles, ending upon complete monomer consumption & termination reactions are minimized. This paper presents a systematic computational study on kinetics & thermodynamics associates in the ATRP of itaconimide monomers & methyl methacrylate (MMA). For this, the copolymerization system is modeled as a unimer, dimer & trimer of various itaconimides & MMA monomer. The density functional theory with B3LYP functional & 6–31 + G(d)/LanL2DZ basis sets is used in the prediction of geometries & energetics associated with the dissociation of terminal R–X bond present in the unimer, dimer & trimer. The relative equilibrium constant (K
ATRP) for the ATRP activation/deactivation steps is calculated from the free energy values associated with dissociation of R–X bond. The relative K
ATRP values of dimer & trimer of selected monomers is compared with their respective unimer. From the transition state geometries of the dimeric propagating radical, activation energy is calculated. The gas phase rate coefficients for propagation (k
p) (of itaconimides & MMA copolymerization) are calculated using the standard transition state theory. The effect of system parameters such as solvent, temperature & substituent on K
ATRP & k
p values of dimer is investigated systematically. The change in the initiating system & temperature has significant effect on k
p values as compared to solvent & various substituent. The K
ATRP values of dimer & trimer dormant species are higher as compared to their respective monomeric species. The neighboring monomer & penultimate monomer plays vital role in kinetics & thermodynamics associated with copolymerization. The obtained initial results show that the mechanism of copolymerization of itaconimide monomers & MMA follows penultimate model.
Cutting Parameter Optimization in Milling of Glass Fiber and Carbon Fiber Reinforced Composites to Reduce Cutting Force
Authors: Ekşi Seçil , Özsoy Murat , Özsoy Neslihan
Published: March 2023

Composite materials are often preferred in many engineering applications because of their lightness and high-strength properties. However, in addition to the advantages of composite materials, processing problems exist. The processing of fiber-reinforced composite materials is more complex than other metal materials. The forces that arise during milling cause undesirable results, such as tool wear and energy loss. In this study, the cutting parameter optimization was made by measuring the force during carbon fiber and glass fiber-reinforced epoxy matrix composites milling. Cutting velocity (90, 120, and 150 m/min) and feed per tooth (0.1, 0.15, and 0.2 mm/tooth) were selected as cutting parameters. Experiments were planned according to the Taguchi method with two parameters and three levels. Optimization of the parameters was evaluated using the signal/noise ratio approach. The effectiveness of parameters on results was determined by analysis of variance (ANOVA). Optimum levels were found as 120 m/min for cutting velocity and 0.1 mm/tooth for feed per tooth both glass fiber-reinforced polymer (GFRP) and carbon fiber-reinforced polymer (CFRP) composites. According to the ANOVA results, the contribution rates of the force parameters were 81.05 % for cutting velocity and 15.03 % for feed per tooth in GFRP composites. The contribution rates of the force parameters were 43.69 % for cutting velocity and 46.18 % for feed per tooth in CFRP composites. The surfaces of the milled samples were examined with an optical microscope to investigate the damage. It was observed that the surfaces of CFRP samples had a better surface quality than GFRP samples.
Machine learning for automatic Alzheimer’s disease detection: addressing domain shift issues for building robust models
Authors: Li Cheng , Elsayed Bakheet Nazik Mohamad Ahmed , Huang Weijian , Wang Shanshan
Published: March 2023

Alzheimer’s disease (AD) is a type of brain disease that affects a person’s ability to perform daily tasks. Modern neuroimaging techniques have made it possible to detect structural and functional changes in the brain that are linked to AD, and machine learning (ML)-based methods have been extensively developed to help physicians achieve fast and accurate imaging-based AD detection. One critical issue when deploying ML methods in clinical applications is the domain shift that exists between the training and test data, which may significantly attenuate a model’s performance. To resolve this issue, domain adaptation (DA) is needed to narrow the performance gap between data from domains with different distributions. The purpose of this review is to offer insight into the state of ML and DA research in the field of neuroimaging-based AD detection. The limitations of existing studies, as well as opportunities for future studies, are discussed with the hope that more investigations will be conducted in the future to optimize the clinical workflow for AD diagnosis and treatment.
A rare case of unusual presentation of acute necrotising pancreatitis as a presenting feature of dengue haemorrhagic fever in a child
Authors: Singh Lakra Mahaveer , Lahiya Sham , J Meshram Rewat , Taksande Amar , Damke Sachin
Published: March 2023

Background: Dengue fever is an acute viral infection seen commonly in developing countries. Its presentation varies in children starting from mild illness to severe complications. Acute necrotising pancreatitis is a serious form of pancreatitis which is a very rare entity in children. Here we are presenting a rare case of unusual presentation of acute necrotising pancreatitis as a presenting feature of dengue fever. Case details: A 15 years male child presented with history of pain, distension of abdomen and vomiting. Patient had history of fever off and on since one month. Per abdomen examination showed ascites, hepatomegaly. Dengue NS1 antigen and dengue serology IgM was positive. Serum amylase level and lipase level were 1540 U/Land 960 U/L respectively. Contrast enhanced CT scan and MRCP showed bulky pancreas with decreased enhancement with ascites. Patient was managed conservatively with intravenous fluids, antibiotics and octreotide and patient was discharged successfully. Acute necrotising pancreatitis as a presenting feature of dengue fever has not been reported in children to the best of my knowledge. Conclusion: Clinical presentation of dengue fever varies but when patient presents with pain in abdomen, vomiting and fever then acute pancreatitis should be ruled out. In such patient clinical suspicion is important and timely intervention may lead to complete recovery and good outcome.
Activity of the cytosolic enzymes of endogenous aldehydes catabolism under the conditions of different nutrients content in a diet
Authors:   Yuriy Fedkovych Chernivtsi National University, Educational and Scientific Institute of Biology, Chemistry and Bioresources, Biochemistry and biotechnology department, 2 Kotsyubinskogo str., Chernivtsi, 58012, Ukraine, Voloshchuk O. M. , Luchyk T. V. ,   Yuriy Fedkovych Chernivtsi National University, Educational and Scientific Institute of Biology, Chemistry and Bioresources, Biochemistry and biotechnology department, 2 Kotsyubinskogo str., Chernivtsi, 58012, Ukraine
Published: March 2023

The research was conducted to study the activity of aldehyde dehydrogenase (EC 1.2.1.3) and aldehyde reductase (EC 1.1.1.21), the levels of TBA reactive substances and protein carbonyl derivates in the cytosolic fraction of rat liver under the conditions of different dietary sucrose and protein content. The animals were distributed into the 4 experimental groups: group I — animals receiving full-value semi-synthetic feed (control group); group II — animals on a low-protein diet (LPD); III group — animals on a high-sucrose diet (HS); IV group — animals on a low-protein and high-sucrose diet (LPD/HS). It was found that in animals under conditions of dietary protein deficiency, there was a two-fold increase in the levels of TBA reactive substances and protein carbonyl derivates in the liver cytosolic fraction against the absence of changes in the aldehyde reductase and aldehyde dehydrogenase activity. At the same time, in animals on a high-sucrose diet, there was a significant accumulation of the TBA reactive substances and carbonyl derivatives in the liver cytosolic fraction along with a 2–2.5-fold increase in both aldehyde reductase and aldehyde dehydrogenase activity. The maximum accumulation of the products of oxidative damage to proteins and lipids along with the insufficient activation of the enzymes ensuring their catabolism can be considered as one of the possible mechanisms of liver cell damage under conditions of the low-protein/high-sucrose diet. The obtained results open new prospects for future studies of the mechanisms of endogenous aldehydes detoxification and further development of a strategy for the correction of metabolic liver disorders under the conditions of nutrient imbalance.
Chromosomal instability of purebred and crossbred dairy cows
Authors:   Institute of Animal Breeding and Genetics named after M. V. Zubets NAAS, 1 Pohrebniaka str, Chubynske village, Boryspil district, Kyiv region, 08321, Ukraine, Dzitsiuk V. , Starodub L. ,   Institute of Animal Breeding and Genetics named after M. V. Zubets NAAS, 1 Pohrebniaka str, Chubynske village, Boryspil district, Kyiv region, 08321, Ukraine, Dyman T. ,   Bila Tserkva National Agrarian University, 8/1 Soborna sq., Bila Tserkva, Kyiv region, 09117, Ukraine
Published: March 2023

The article presents the results of research on the karyotype characteristics variability in purebred and crossbred dairy cows. The material for the research was peripheral blood samples of purebred firstborn cows of the Ukrainian red-spotted dairy and Ukrainian black-spotted dairy breeds, as well as crossbred cows obtained from crossing Ukrainian red-spotted with Montbeliard bulls (DG “Nyva” SE of the Institute of Animal Breeding and Genetics named after M. V. Zubets NAAS. Preparation of cytogenetic preparations, analysis of morphology, identification and classification of chromosome aberrations were carried out according to generally accepted methods. We performed cell analysis with the Axiostar plus microscope (Carl Zeiss, Germany) under immersion magnification of 1000 times and took microphotographs. In all studies, the frequency of aberrant metaphases and the spectrum of chromosomal aberrations were determined as parameters of chromosomal instability. The following signs were taken into account: the frequency of aneuploid and polyploid cells, cells with premature separation of the centromeric regions of chromosomes (CRC), cells with structural aberrations of chromosomes (breaks, fragments and associations of non-homologous chromosomes). As a result of the analysis of karyotypes of firstborn cows of purebred and crossbred origin, it was established that the proportion of diploid cells in the norm is on average 85%. The remaining almost 15% are somatic cells with numerical and structural abnormalities. Crossbred cows have significantly higher frequencies (P<0.001) of aneuploid (one and a half times), polyploid (by 27%), structural aberrations of chromosomes (by 20%) than in purebred cows of the Ukrainian red-spotted and black-spotted dairy breeds. 15–20% more cells containing chromosomes with breaks and fragments were also found in crossbred firstborns. The results of the cytogenetic study indicate greater chromosomal instability in crossbred cows compared to purebred cows. One of the reasons for this phenomenon may be the influence of breeding methods, in particular crossbreeding.
One-Year Follow-up After a Pregnancy Prevention Intervention for LGB+ Teens: An RCT
Authors: Ybarra Michele , Rosario Margaret , Saewyc Elizabeth , Goodenow Carol , Dunsiger Shira
Published: March 2023

BACKGROUND

Lesbian, gay, bisexual, and other sexual minority (LGB+) girls are more likely than heterosexual girls to be pregnant during adolescence. Nonetheless, LGB+ inclusive pregnancy prevention programming is lacking.

METHODS

Between January 2017 and January 2018, 948, 14 to 18 year-old cisgender LGB+ girls were enrolled in a national randomized controlled trial. Girls were assigned either to Girl2Girl or an attention-matched control group. They were recruited via social media and enrolled over the telephone. The 5-month intervention consisted of a 7-week program (4–12 text messages sent daily) and a 1-week booster delivered 12 weeks later. Longitudinal models of protected sex events had a negative binomial distribution and a log link function. Longitudinal models examining use of birth control assumed a Bernoulli distribution of the outcome variable and a logit link function. Models adjusted for baseline rate of the outcome, age, and a time-varying indicator of sexual experience.

RESULTS

Girl2Girl participants had higher rates of protected penile-vaginal sex events over time compared with controls. Girl2Girl participants also were more likely than control participants to report use of birth control other than condoms. Models of abstinence and pregnancy rates did not suggest statistically significant group differences across time. However, effect sizes were in the small to medium range and point estimates favored Girl2Girl versus control in both cases.

CONCLUSIONS

Girl2Girl is associated with sustained pregnancy preventive behaviors for LGB+ girls through 12 months postintervention. Text messaging could be considered as a viable method to increase access to sexual health programming to adolescents nationally.
Syntéza estetiky a historiosofie v kontextu ruského symbolismu
Authors: Vorel Jan
Published: March 2023

The aim of the study is to point out the inner connections between aesthetic-philosophical concepts of the selected Russian symbolists and the historiosophy. In the aesthetic theories of D. S. Merezhkovsky and A. Bely we can find particular ideas that confirm their interest in the meaning of culture and civilization.
Władza przestrzeni. Step Antoniego Czechowa
Authors: Ziomek Marcin
Published: March 2023

The present article attempts to analyse The Steppe by Anton Chekhov in the context of the power held by endless space over the fates of Russians. The protagonist’s journey into adulthood becomes a pretext for the writer to explore issues related to Russian mentality.
A Characterization of T1 Spaces via Limit Sets of Nets
Authors: Chou Yu-Lin
Published: March 2023

This article indicates another set-theoretic formula, solely in terms of union and intersection, for the set of the limits of any given sequence (net, in general) in an arbitrary T1 space; this representation in particular gives a new characterization of a T1 space.
A CORPORIFICAÇÃO DE ENTES QUÍMICOS EM PERFORMANCES MULTIMODAIS EM AULAS DE CIÊNCIAS
Authors: Aizawa Alexandre , Botelho Maria Luiza Silva Tupy , Quadros Ana Luiza de , Giordan Marcelo
Published: March 2023

Partimos da premissa de que a representação e o conceito estão diretamente relacionados quando se trata de ensino e aprendizagem de Química. Neste artigo analisamos dois episódios de ensino nos quais foram executadas performances corporais com o objetivo de investigar os significados produzidos nas aulas em que o corpo foi empregado para representar um ente químico. Esses episódios foram extraídos dos vídeos produzidos por dois grupos de pesquisa em ensino de Química. Foram evidenciados nas análises os recursos modais empregados pelos professores durante a representação com o corpo e os possíveis significados produzidos junto aos estudantes. A análise indicou que os estudantes perceberam o comportamento do ente químico nos sujeitos que representavam os átomos e que essa corporificação apresentou affordances que auxiliaram no entendimento dos conceitos explorados durante a performance. Os dados nos levam a argumentar que o corpo e os movimentos também produzem aprendizagens. Representar um ente químico usando o corpo se mostrou uma estratégia racional e afetiva no entendimento dos conceitos, o que traz implicações para a formação de professores no sentido de superar obstáculos epistemológicos e afetivos.
A Study on the Paradigm Shift in Regional Trade Agreements: A Comparative Analysis of Traditional RTAs and 21st Century RTAs
Authors:   The Korea International Trade Research Institute, Cheong Sun-Tae
Published: March 2023

Purpose – This study aims to analyze the paradigm shift of regional trade agreements in the 21st century. In addition, it analyzes the limitations of WTO RTA statistics and the problems of classification criteria, and suggests alternatives. Design/Methodology/Approach – This paper uses a literature review to examine new issues related to the paradigm shift of regional trade agreements. To support the analysis, statistical techniques are used to count the number of regional trade agreements by type, provision, and coverage, using the WTO RTA database. Findings – The results of this study show that the nature and content of regional trade agreements are changing. Traditional regional trade agreements and 21st century regional trade agreements show that there is a significant difference based on the time of integration, trade pattern, trade barriers, and type of integration. It also finds that there are problems with the WTO's RTA statistics and classification of types. Research Implications – This paper analyzes the paradigm shift of new regional trade agreements by comparing them with traditional regional trade agreements. At the same time, in order to support the systematic analysis of regional trade agreements, the limitations of WTO statistics and problems of classification criteria were analyzed, and alternatives were suggested.
A Study on the Interrelationship Among Import Volume, Export Volume and the Effects of Korean Wave: Focusing on BTS
Authors:   The Korea International Trade Research Institute, Yim Byung-Jin
Published: March 2023

Purpose – This study is an empirical study on the relationship among export volume and import volume, with BTS internet search trends indexed. Design/Methodology/Approach – In this study, we used 111 monthly data sets on BTS internet search trends, the export volume, and the import volume from April 30, 2013 to Jun 30, 2022. We try to analyze the mutual influence and causality among BTS internet search trends, the export volume, and the import volume. We seek to analyze the extent of any cross-influence. We employ a variance decomposition function based on a VAR model, as well as impulse response after a cointegration test and unit root test. Findings – The important results of this study are summarized as follows. First, there is at least one cointegration among the first differential data of BTS internet search trends, export volume, and import volume. Secondly, import volume does have Granger causality with BTS internet search trends. The export and import volume show Granger causality. BTS internet search trends and the export volume have Granger causality with BTS internet search trends and export volume. Research Implications – This study differs in that it uses BTS internet search trends and the Korean wave. It has limitations in that the study period is short and the study sample is limited.
AŞILAMA KONULU KAMU POLİTİKALARININ KARŞILAŞTIRMALI BİR ANALİZİ
Authors: SEMERCİ Hasret , YILDIZ Mete
Published: March 2023

Halk sağlığı açısından acil durumlara sebep olan bulaşıcı hastalık salgını gibi felaketler hem milyonlarca insanın ölümüne hem de sosyal, politik ve ekonomik sistemlerin dengesinin bozulmasına neden olabilmektedir. Bu duruma en güncel örnek COVID-19 salgınıdır. Bu sebeple çalışma, kamu politikası uygulama örneği olarak COVID-19 salgını başta olmak üzere çeşitli salgınları ve aşı ile önlenebilir hastalıkları kontrol altına almaya yönelik geliştirilen kitlesel aşı politikalarının tasarım ve uygulama aşamalarını incelemiştir. Genel olarak tıp alanının inceleme konusu olan aşılama politikalarına kamu politikası açısından bir bakış sunularak bu politikaların çok-disiplinli bir bakış açısıyla ele alınması hedeflenmiştir. Bu doğrultuda özellikle aşılama politikalarını başarısız kılan etkenler hakkındaki ikincil veriler toplanmış ve bu veriler ışığında, gelecekteki aşılama politikalarının daha etkin yürütülmesine katkı sağlayabileceği düşünülen birtakım öneriler sunulmuştur. Bu öneriler; 1- Aşı kampanyalarına daha fazla önem verilmesi, 2- Karar verme süreçlerinin geliştirilmesi ve hızlandırılması, 3- Şeffaflığın ön planda tutulması, 4- Dengeli aşılama politikaları oluşturulması, 5- Yeni teknolojilere yeterli bütçe ayrılması, 6- Aşı uygulamalarında denetimlerin artırılması, 7- Halkın güveninin kazanılması, 8- Sağlık çalışanları ve diğer paydaşlar ile iş birliği yapılması, 9- Ebeveynlere ve bakıcılara özel eğitimler düzenlenmesi, 10- Bilgi eksikliği ile mücadele edilmesi, 11- Kitle iletişim araçlarının doğru ve etkin kullanılması, olarak özetlenebilir.
Fabrication of (Ti-Al-Si)/(Ti-C)/Ti – layered alloy by SHS pressing
Authors: Lazarev P. A. , Busurina M. L. , Gryadunov A. N. , Sytschev A. E. , Belikova A. F.
Published: March 2023

A metal-carbide-intermetallic material based on combustion products of the layer system (Ti-Al-Si)/(Ti-C)/Ti was for the first time obtained with the help of self-propagating high-temperature synthesis (SHS) combined with pressing. Exothermic synthesis from elementary powders was carried out at a pressure of 10 MPa, and pressing of the hot synthesis product was carried out at a pressure of 100 MPa. It has been shown that SHS pressing contributes to the formation of permanent joints of «metal/carbide/intermetallic» layers. The main features of microstructure formation, phase composition, and strength properties of transition zones at the boundary between reacting SHS compositions, Ti-C and Ti-Al-Si and Ti-metal substrate are investigated. It is shown that during SHS reaction, a homogeneous microstructure of Ti-C and Ti-Al-Si layers with an insignificant content of cracks and pores is formed. The thickness of the transition zone between the layers was at least 15 µm. The main phase formed in the combustion product of Ti-Al-Si layer is, according to the results of X-ray phase analysis, triple phase Ti20Al3Si9, the content of which, calculated by the Rietveld method, was at least 87 wt. %. In addition, the combustion product contains a secondary phase of Ti3Al in the amount of 13 wt. %. The energy dispersion analysis revealed that diffusion of aluminium through the titanium carbide layer into the titanium substrate to a depth of approx. 30 µm is observed. Microhardness value of the combustion product of Ti-Al-Si layer was about 10 GPa. The rectilinear nature of crack propagation in the synthesized combustion product of Ti-Al-Si layer, as well as the Palmquist crack resistance coefficient varying within 5.1-5.7 MPa·m1/2, indicate the fragility of the material.
The influence of Ni on the composition, structure and properties of Ti-Cr-N coatings
Authors: Chernogor A. V. , Blinkov I. V. , Belov D. S. , Sergevnin V. S. , Demirov A. P.
Published: March 2023

The influence of nickel on the structure and properties of Ti-Cr-N ion-plasma coatings obtained by arc-PVD method has been studied. With a nickel content of up to 11.9 at. %, the coating consists of Cr2N, Ti1 – xCrxN, and metallic Ni. Upon further increase in Ni concentration in the coating, intermetallic compound Ni3Ti is formed. The structure of the coatings was studied using the transmission electron microscopy. The coatings of Ti-Cr-N system are characterized by a columnar structure, in the columns of which Ti1 - xCrxN and Ti1 - yCryN (x > y) sublayers, being several nanometers thick and containing variable concentration of titanium and chromium, as well as Cr2N sublayers of about 25 nm are formed due to the complete solubility of TiN and Cr2N and the planetary rotation of the substrates, resulting in layer-by-layer stacking of the components of the evaporated cathodes. This structure remains intact in coatings of Ti-Cr-N-Ni system with a low nickel concentration (on the order of tenths of at. %). However, upon that, the column size refinement and an increase in biaxial compressive stresses from 6.7 to 9.7 GPa are observed, which results in an increase in hardness from 30 to 42 GPa. The coatings with a high nickel content are characterized by a multilayer architecture with an equiaxed polycrystalline structure of nanograins in layers. As Ni concentration increases, the hardness of the coating decreases to 16.7 GPa, which is associated with an increase in the fraction of relatively soft nickel in the coating and a decrease in macrostresses to -0.6 GPa. Upon that, the wear intensity increases from 3·10-15 to 5·10-15 m3/(N·m). The studied coatings of Ti–Cr–N and Ti–Cr–N–Ni systems are resistant to adhesive and cohesive destruction. With an increase in the nickel content upon measuring scratching, the destruction of the coatings occurs exclusively due to the plastic deformation.
Infection and Recurrence Rates in Rural Inguinal Hernia Repair
Authors: Fowler Brooke , Hughes Dorothy
Published: March 2023

Introduction. Inguinal hernia repair (IHR) is a common procedure performed by general surgeons in rural community hospitals. Infection and recurrence rates for three types of IHR over two years at a rural Kansas hospital were analyzed. Previous research has shown outcomes regarding pain at six weeks were typically no different, and neither were long-term results, between open and laparoscopic techniques. However, there were fewer data showing the outcomes of these three hernia repair approaches in rural settings.
Methods. This was a retrospective, cross-sectional study using data collected from the electronic medical record (EMR) of a small hospital in central Kansas. Data from adult patients who had undergone IHRs over a two-year period (2018-2019) were deidentified and described using frequencies and percentages. This study used multi-variate logistic regression to examine the association of patient, surgeon, and surgical procedure characteristics on the occurrence of post-operative complications.
Results. Of the patients who received IHR, 46 were male and 5 were female. Mean age was 66 years, with a minimum of 34 and maximum ≥ 89 years. There were 14 total post-operative complications; two were superficial infections. There were no recurrences.
Conclusions. The sample size for each procedure type was too small to allow for statistical testing. However, the hospital had no recurrences. Future research should follow-up with this and other rural hospitals and perform a direct comparison of hernia surgery outcomes with those at a larger, more urban hospital, to understand potential differences by hospital size.
НЕЛИНЕЙНЫЕ МЕТОДЫ ПОЛУЧЕНИЯ ЗАДАННЫХ РЕЗУЛЬТАТОВ, ИНФОРМАЦИИ И ПРОГНОЗИРОВАНИЯ
Authors: Комиссарова Мария Анатольевна , Семенова Вера Николаевна
Published: March 2023

Целью исследования является рассмотрение нейробиологических технологий, психологических исследований при прогнозировании заданных результатов и их сферы применения в современном мире, описание преимуществ нелинейных методов прогнозирования перед традиционными.

Методологическую базу исследования представляют теоретические основы линейных и нелинейных методов прогнозирования нейробиологические и психологические исследования, а также многочисленные данные, полученные практическими исследованиями в мировых институтах и частных лабораториях как в России, так и за рубежом.

Результаты исследования показывают, что разработанные западные методы значительно уступают методам, которые разработаны в России и уже внедряются в других странах. В статье дается понятие энтропийной логики, описывается сравнение зарубежных методов с отечественными. Рассматриваются преимущества российских методов перед западными нейробиологическими технологиями в разных сферах применения. Рассмотрены связи между различными сферами, такими как спорт, политика, психология, экономика, медицина.

Перспективы исследования заключаются в необходимости развития нелинейных методов и их популяризации не только на макро-, но и на микроуровне, сделав доступным обучение технологиям для всех слоев населения, а также внедрение в корпоративную культуру предприятий и различных организаций.
КОММЕРЦИАЛИЗАЦИЯ СПОРТИВНОЙ ДЕЯТЕЛЬНОСТИ В ГЛОБАЛЬНОМ СЕТЕВОМ ОБЩЕСТВЕ
Authors: Герасимов Максим Васильевич
Published: March 2023

Цель исследования заключается в анализе факторов, способствующих коммерциализации спорта в условиях развития глобального сетевого общества.

Методологической основой исследования выступают положения теории глобализации (К. Омае), информационного общества, концепции сетевого общества М. Кастельса.

Результаты исследования. Современная спортивная деятельность как микромодель социальной системы отражает в себе все ключевые тенденции мирового развития. В условиях глобализации рынков, формирования потребительской модели общества коммерциализация спортивной деятельности представляет собой закономерный процесс, обусловленный развитием рыночных отношений, распространением либеральных идей, развитием информационных и медиатехнологий.

Перспективы исследования. Работа открывает перспективы для дальнейшего исследования положительных и негативных тенденций в процессах трансформации спортивной деятельности.
ЭКОЛОГИЧЕСКИЙ ИМПЕРАТИВ И ПРОБЛЕМЫ НАЦИОНАЛЬНОЙ БЕЗОПАСНОСТИ СОВРЕМЕННОЙ РОССИИ
Authors: Попов Евгений Сергеевич
Published: March 2023

Целью исследования в представленной статье является рефлексия экологического императива и проблем национальной безопасности, а также определение места и роли экологического императива в национальной безопасности современной России.

Методологию исследования составляет междисциплинарный подход, позволяющий осуществить рефлексию экологического императива в национальной безопасности с учетом современных достижений социально-гуманитарного и естественнонаучных направлений мысли. В то же время, обращаясь к работе по экологическому императиву отечественного ученого Н. Н. Моисеева, автор статьи приходит к выводу о необходимости использования диалектического подхода для конкретного рассмотрения данного феномена.

Результаты исследования. Экологический императив представляет собой границу в ресурсопользовательской деятельности людей, разделяющую два качественных состояния природной среды. Вместе с тем экологический императив в рамках национальной безопасности есть состояние экологической безопасности, выход за границу которой неизбежно ведет к экологическому кризису как превращению результатов человеческой деятельности в негативные силы, воздействующие на здоровье людей. В то же время угрозами национальной безопасности России являются внешние и внутренние тенденции к экологическому кризису.

Перспектива исследования связана с дальнейшим осмыслением экологического императива как границы деятельности людей в пространстве современной России.
О РАЗРАБОТКЕ СТРАТЕГИИ ДЕЙСТВИЙ ПО СБЕРЕЖЕНИЮ МУЖЧИН И ПОДДЕРЖКЕ ОТВЕТСТВЕННОГО ОТЦОВСТВА: АВТОРСКИЙ ВЗГЛЯД
Authors: Ростовская Тамара Керимовна
Published: March 2023

Актуальность исследования определяется неблагоприятными демографическими тенденциями — снижением численности мужского населения, что негативно влияет на процессы естественного воспроизводства. Брачные и репродуктивные установки мужчин являются факторами достижения демографической устойчивости Российской Федерации, влияющими на создание и развитие института детной (многодетной) российской семьи.

Целью исследования является определение основных направлений государственной политики в отношении самосохранительного поведения мужчин и укрепления социодемографического капитала мужской популяции как основного ресурса обеспечения национальной безопасности Российской Федерации. Мужчины как социально-демографическая группа должны стать целевой группой в Стратегии действий по сбережению мужчин и поддержке ответственного отцовства, достижения демографической устойчивости Российской Федерации.

Методологическую базу исследования представляют базисные положения концепции самосохранительного поведении, благополучия семьи.

Результаты исследования. Важнейшим итоговым результатом проведенного анализа по заявленной проблематике является необходимость принятия на государственном уровне мер, направленных на создание условий для сбережения мужского населения и формирования ответственного отцовства как важного ресурса обеспечения национальной безопасности Российской Федерации.

В работе систематизированы ключевые понятия, представлены результаты, направленные на определение основных направлений государственной политики в отношении самосохранительного поведения мужчин, ответственного отцовства.

Перспективы исследования связаны с разработкой методических рекомендаций субъектам Российской Федерации по формированию региональных планов и управленческих механизмов, направленных на создание условий для сбережения мужского населения и формирования ответственного отцовства как важного ресурса обеспечения национальной безопасности Российской Федерации.
СТРАТЕГИИ САМОРЕАЛИЗАЦИИ СОВРЕМЕННОЙ МОЛОДЕЖИ НА СЕЛЬСКИХ ТЕРРИТОРИЯХ (НА ПРИМЕРЕ МАТВЕЕВО-КУРГАНСКОГО РАЙОНА РОСТОВСКОЙ ОБЛАСТИ)
Authors: Середа Марина Викторовна , Остапенко Диана Константиновна
Published: March 2023

Целью исследования является анализ социальных проблем сельской молодёжи и разработка стратегий по их самореализации на сельских территориях (на примере Матвеево-Курганского района Ростовской области).

Методологическую базу исследования составляют оценочные данные социологического опроса.

Результаты исследования включают обзор основных проблем миграции сельской молодёжи. Снижение проблем по самореализации, возникающих у молодого населения, проживающего на сельских территориях, возможно только через политику, причём целостную и конструктивную, направленную на улучшение жизнедеятельности молодых сельских жителей.
АНАЛИЗ ИСПОЛЬЗОВАНИЯ АВТОМАТИЗИРОВАННЫХ СИСТЕМ УПРАВЛЕНИЯ ОТЕЧЕСТВЕННЫМИ ПРЕДПРИЯТИЯМИ
Authors: Влад Михаил Михайлович , Куликов Михаил Михайлович
Published: March 2023

Целью исследования является выявление преимуществ использования автоматизированных систем управления предприятиями.

Методологическую базу исследования составляют статистические данные российских рейтингов использования ERP-систем, научные статьи и публикации, теоретические труды, практические разработки отечественных и зарубежных ученых, статистические наблюдения и элементы сравнительного анализа. Рассмотрение, изучение и использование данных материалов позволяет оценить перспективы использования российских автоматизированных систем управления предприятиями.

Результаты исследования. Рассмотрены этапы и особенности развития автоматизированных систем управления предприятием. Представлены понятия, сущность и функции ERP-систем. Проанализирован жизненный цикл ERP-системы и расходы, возникающие на каждом из этапов. Представлены основные преимущества внедрения автоматизированных систем управления в контексте повышения конкурентоспособности предприятий. Приведены примеры внедрения данных систем на отечественных предприятиях.

Перспективой исследования является рассмотрение и выявление перспектив использования российских автоматизированных систем управления предприятиями.
Matematik Öğretmenlerinin Perspektifinden Matematik Öğretiminde Üst Düzey Düşünme Becerilerinin Geliştirilmesi
Authors: KARADEM Zarife Gökçen , YAKIT ONGUN Mevlüde , TAŞ Said
Published: March 2023

Araştırmanın amacı, matematik öğretiminde üst düzey düşünme becerilerinin nasıl geliştirileceğinin incelenmesidir. Araştırma nitel araştırma yaklaşımlarından durum çalışmasına göre yürütülmüştür. Çalışma grubunu amaçlı örnekleme yöntemi ile belirlenen 28 matematik öğretmeni oluşturmuştur. Araştırmada veri toplama aracı olarak yarı yapılandırılmış görüşme soruları ve araştırmacı günlüğü kullanılmıştır. Veriler içerik analizi ile analiz edilmiştir. Verilerin analizinde MAXQUDA 2020 programı kullanılmıştır. Bulgulara göre; matematik öğretmenleri üst düzey düşünmeyi eleştirel yaklaşım, sorunun üstesinde gelme, problemlere farklı çözüm yolları geliştirme olarak ifade etmektedir. Üst düzey düşünme becerileri öğrencilerin çoğunluğunda alt seviyelerdedir. Matematik öğretmenlerinin üst düzey düşünme becerilerini geliştirebilmek için derslerinde çeşitli uygulamalara yer verdikleri, ancak söz konusu becerileri yeterince geliştiremediklerini düşündükleri ortaya çıkmaktadır. Matematik öğretmenleri öğrencilerdeki üst düzey düşünme beceri seviyelerinin alt seviyelerde olmasının ve derslerde yeterince geliştirilememesinin sebeplerini öğrenci, öğretmen, sistemsel ve toplum/aile açısından ortaya koymaktadırlar. Araştırmada matematik öğretiminde üst düzey düşünme becerilerinin geliştirilmesi için öğrenci, öğretmen, toplum/aile, matematik öğretim süreci, eğitim politikasına yönelik olarak neler yapılabileceğine dair sonuçlar elde edilmiştir. Matematik öğretmenlerinin perspektifinden yapılan bu araştırmanın sınıf öğretmenleri ve ortaokul matematik öğretmenleri üzerinde yapılması önerilebilir.
Analysis of somatic mutations in the JAK2, CALR, MPL and ASXL1 genes and evaluation of their impact on the survival of patients with myelofibrosis
Authors: Subbotina T. N. , Maslyukova I. E. , Semashchenko K. S. , Khodos G. A. , Kurochkin D. V. , Shalyova A. A. , Mikhalev M. A. , Vasiliev E. V. , Osadchaya M. G. , Dunaeva E. A. , Esman A. S. , Mironov K. O.
Published: March 2023

Background. The development of myelofibrosis (MF) is driven by complex molecular genetic events that include driver somatic mutations responsible for the constitutive activation of the JAK/STAT signaling pathway (JAK2, CALR, and MPL), additional mutations affecting epigenetic regulators (TET2, ASXL1, IDH1/2, etc.) and RNA splicing (SRSF2, U2AF1, SF3B1, etc.), as well as genetic aberrations that contribute to genomic instability and disease progression.

Aim. To analyze driver (JAK2, CALR, MPL) and prognostic (ASXL1) somatic mutations in patients with MF and evaluate their impact on survival.

Materials and methods. The study included 29 patients diagnosed with MF, selected by hematologists from the City Clinical Hospital No. 7 and Regional Clinical Hospital (Krasnoyarsk).

Results. 26 (89.6 %) out of 29 examined patients had some driver mutations in JAK2, CALR, MPL genes. The p.V617F mutation in the JAK2 gene was found in 20 (68.9 %) patients. Mutations in the CALR gene were detected in 4 (13.8 %) patients, mutations in the MPL gene were found in 3 patients (10.3 %). In 1 of 26 patients, 2 driver mutations were present simultaneously. 3 (10.3 %) patients were triple negative. Mutations in the ASXL1 gene were detected in 12 (41.4 %) out of 29 examined patients. Conducted targeted NGS (next generation sequencing) for 13 out of 29 patients revealed additional genetic variants that contribute to the understanding of the development mechanism and disease course. When evaluating the overall survival in the groups of patients diagnosed with MF examined by us, depending on the combination of driver (JAK2, CALR, MPL) and prognostic (ASXL1) mutations, no statistically significant differences were found (p = 0.12). This appears to be due to the small sample size. At the same time, assessment of patient survival depending on ASXL1 status showed that in the presence of mutations in the ASXL1 gene, the median survival was 45 months (range 7–120 months), while in the absence of mutations it was 48 months (range 21–359 months) (p = 0.03).

Conclusion. The results obtained allow us to assume that the presence of mutations in the ASXL1 gene is an unfavorable factor in the course of the disease.
Serrated colonic lesions. Current review
Authors: Vereshchak V. V. , Iurichev I. N.
Published: March 2023

Serrated lesions, as a rule, were considered benign and were likened to hyperplastic polyps by anatomists and gastroenterologists. These views persisted until about 2010. However, recent data showed that serrated lesions can potentially transform into colorectal cancer (CRC). The World Health Organization classification identifies 4 categories of serrated lesions: hyperplastic polyps, sessile serrated lesions, traditional serrated adenoma and unclassified serrated adenomas. Sessile serrated lesions with dysplasia and traditional serrated adenomas are the most common precursors of CRC. Development of CRC from serrated lesions occurs through two different molecular pathways, namely, sporadic microsatellite instability and CpG island methylator phenotype, and the latter is considered the main mechanism inactivating serrated CRC pathway. In contrast to adenoma–carcinoma pathway, APC-inactivating mutations are rare in serrated adenomas.
RESULTS OF GEOPHYSICAL MONITORING OF THE DEVELOPMENT OF THE HORIZON PK-2 OF THE PODKIRMAKINSKY SUITE OF THE NEFT DASHLARY FIELD
Authors:   Institute of Oil and Gas of Azerbaijan National Academy of Sciences, Gahramanli S.
Published: March 2023

The article is devoted to the study of the current state of development of the second horizon of the Podkirmakinsky suite (PK-2) of the Productive stratum (PS) of the Neft Dashlary field, which has been in operation for more than 60 years. The results of the study by the method of complex areal interpretation of geophysical survey data of wells and geological and field information are presented. Three-dimensional geo models, built on the basis of petrophysical parameters obtained after the interpretation of geophysical and geological data using the DV Seys Geo program are given in the article. The results of the analysis of the state of water impact are presented, the values of the oil saturation factor during well drilling are summarized, the values of the current oil saturation factor are calculated taking into account the extraction of oil, the results of studying the nature of saturation of reservoirs in the context of production wells by the method of pulsed neutron logging (PNL), as well as a comparative analysis of these values along the horizon PK-2 of the PS of the Neft Dashlary field.
CURRENT STATE OF MINERAL BASE OF TITANIUM DEPOSITS OF UKRAINE
Authors:   Institute of Geological Sciences of the National Academy of Sciences of Ukraine, Ganzha O. , Kuzmanenko H. ,   Institute of Geological Sciences of the National Academy of Sciences of Ukraine, Okholina T. ,   Institute of Geological Sciences of the National Academy of Sciences of Ukraine, Remezova O. ,   Institute of Geological Sciences of the National Academy of Sciences of Ukraine
Published: March 2023

The current state of titanium deposits in the world and Ukraine's place in the world of titanium ore reserves are analyzed. The list of leading countries in terms of reserves of loose titanium-zirconium ores and the dynamics of production is given. There is no regularity of the ratio of countries in terms of reserves and countries in terms of production. A map of the countries to which Ukraine exports titanium raw materials and the dynamics of titanium dioxide prices over the past 5 years are presented. The list of available mining enterprises for enrichment and production of titanium products within Ukraine is given. The general characteristic of the mineral resource base of titanium of Ukraine with the map of the current state of ilmenite and complex zircon-ilmenite placers of the Ukrainian Placer Province is provided.
Morphological assessment of changes in internal organs of rats with introduction of targeted drug “Sutent” in experiment
Authors: Gulyaeva Natalya I. , Vdovina G. P. , Freind G. G. , Burlutskaya A. A. , Chugunova M. P. , Karipova M. O.
Published: March 2023

Objective. To establish in the experiment the changes in histological structure of the internal organs and blood indices in laboratory rats with intragastric introduction of the drug Sutent in the doses of 7 mg/kg and 35 mg/kg of the weight.
Materials and methods. The study was conducted on 48 breedless white rats divided into the following groups: groups 1 and 4 received cytotoxic drug Sutent in the dose of 7 mg/kg (therapeutic dose), groups 2 and 5 Sutent in the dose of 35 mg/kg (fivefold exceeding the therapeutic dose), groups 3 and 6 the control groups. In groups 1, 2, 3 animal were killed 30 days after the onset of the experiment, in groups 4, 5, 6 two weeks after the drug withdrawal. Every day during 30 days, the experimental groups were introduced the intragastric drug Sutent in the form of aqueous suspension in the purified water; in the control group the rats received the purified water in the equivalent volume. The histological preparations of organs stained with hematoxylin and eosin as well as the hematological indices of blood were investigated.
Results. The development of hypochromic anemia, thrombocytopenia and granulocytopenia in the was identified. While studying the histological structure of organs, in all experimental groups there was detected a disturbed circulation in the form of venous hyperemia and blood stasis in the capillaries, the development hemorrhages in the lung, liver, kidneys, adrenal glands, pancreas, gastric and esophageal mucosa. In the liver, pancreas and adrenal glands, dystrophic changes in the cells and necrosis foci were observed. In group 2, affection of the cerebral cortex nerve cells, heart cardiomyocytes, thyroid cells, acute duodenitis with formation of microabscesses was established.
Conclusions. Introduction of Sutent in the dose of 35 mg/kg, compared with the dose of 7 mg/kg, caused a more expressed hematological, hepatological, cardiological and neurological toxicity, more obvious lesion of endocrine organs; it also contributed to the development of associated secondary infection and acute duodenitis.
Dedicated to Veniamin Arsenievich Sitnikov (1936–2022), honoured doctor of the Russian Federation
Authors: Styazhkina Svetlana N. , Voinova Alina A. , Tursukova Polina A.
Published: March 2023

The article is dedicated to the memory of the Honoured Doctor of the Russian Federation, Doctor of Medical Sciences, member of the European Association of Intensive Care, Academician of the Russian Academy of Laser Sciences, outstanding professor, member of the International Association of Hepatologists, Veniamin Arsenyevich Sitnikov.