bluuebunny/crossref_metadata_2025 huggingface dataset:
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Cholic Acid (MT921) after a Subcutaneous Injection in the Submental Area to Humans
Authors: Chung Hyewon , Park Jin-Woo , Kim Dai-Hyun , Seo Soo-Hong , Kim Kyoung-Ah , Lee Woo-Shun , Park Ji-Young
Published: August 2021

This study aimed to explore pharmacokinetics, pharmacodynamics, and safety/tolerability of MT921, an injectable cholic acid, after a single subcutaneous administration to healthy volunteers. A randomized, double-blinded, placebo-controlled, single dose-ascending phase 1 study enrolled 24 subjects who were assigned to three groups (60 mg, 120 mg, and 150 mg) of MT921. Blood samples were obtained for a 24-h period before and after injecting MT921 to the submental fat area. Plasma concentrations of cholic acid and deoxycholic acid were determined for pharmacokinetic analysis. Levels of free fatty acid, triglyceride, and total cholesterol were measured for pharmacodynamic analysis. Safety and tolerability were assessed until 21 days post-dose. While systemic exposure to cholic acid tended to increase as the MT921 dose increased, pharmacokinetic profiles of deoxycholic acid were similar among dose groups without showing significant changes. Pharmacodynamic profiles were comparable when measured at baseline and post-dose. The most frequent adverse events were injection site pain and edema. All adverse drug reactions resolved without treatment. MT921 appeared to be well-tolerated after an injection to the submental area at a dose up to 150 mg. Systemic exposure to cholic acid increased as the dose increased. Blood lipid profiles and deoxycholic acid levels were not affected by MT921 treatment.
Model-Informed Repurposing of Medicines for SARS-CoV-2: Extrapolation of Antiviral Activity and Dose Rationale for Paediatric Patients
Authors: Romano Federico , D’Agate Salvatore , Pasqua Oscar
Published: August 2021

Repurposing of remdesivir and other drugs with potential antiviral activity has been the basis of numerous clinical trials aimed at SARS-CoV-2 infection in adults. However, expeditiously designed trials without careful consideration of dose rationale have often resulted in treatment failure and toxicity in the target patient population, which includes not only adults but also children. Here we show how paediatric regimens can be identified using pharmacokinetic-pharmacodynamic (PKPD) principles to establish the target exposure and evaluate the implications of dose selection for early and late intervention. Using in vitro data describing the antiviral activity and published pharmacokinetic data for the agents of interest, we apply a model-based approach to assess the exposure range required for adequate viral clearance and eradication. Pharmacokinetic parameter estimates were subsequently used with clinical trial simulations to characterise the probability target attainment (PTA) associated with enhanced antiviral activity in the lungs. Our analysis shows that neither remdesivir, nor anti-malarial drugs can achieve the desirable target exposure range based on a mg/kg dosing regimen, due to a limited safety margin and high concentrations needed to ensure the required PTA. To date, there has been limited focus on suitable interventions for children affected by COVID-19. Most clinical trials have defined doses selection criteria empirically, without thorough evaluation of the PTA. The current results illustrate how model-based approaches can be used for the integration of clinical and nonclinical data, providing a robust framework for assessing the probability of pharmacological success and consequently the dose rationale for antiviral drugs for the treatment of SARS-CoV-2 infection in children.
Efficacy of Combined Rifampicin Formulations Delivered by the Pulmonary Route to Treat Tuberculosis in the Guinea Pig Model
Authors: Garcia-Contreras Lucila , Sethuraman Vasu , Kazantseva Masha , Hickey Anthony
Published: August 2021

Liposomes, as vehicles alone or in combination with rifampicin (RIF) microparticles (RMs), were evaluated as vehicles to enhance the permeation of RIF into granulomas. RIF liposomes (RLs) were extruded through a 0.1 µm polypropylene membrane. RMs were prepared by the solvent evaporation method. Four weeks after infection, guinea pigs (GPs) were assigned to groups treated with a combination of RM-RLs or RLs alone. RLs were nebulized after extrusion whereas RMs were suspended in saline and nebulized to GPs in a nose-only inhalation chamber. Necropsy was performed after the treatment; the lungs and spleen were resected for bacteriology. RLs had mean diameters of 137.1 ± 33.7 nm whereas RMs had a projected area diameter of 2.48 µm. The volume diameter of RMs was 64 ± 1 µm, indicating that RMs were aggregated. The treatment of TB-infected GPs with RLs significantly reduced their lung bacterial burden and wet spleen weight compared with those treated with blank liposomes. The treatment of TB-infected animals with RM-RLs also reduced their lung bacterial burden and wet spleen weight even though these reductions were not statistically different. Based on these results, the permeation of RIF into granulomas appears to be enhanced when encapsulated into liposomes delivered by the pulmonary route.
Recovery from Idiopathic Facial Paralysis (Bell’s Palsy) Using Photobiomodulation in Patients Non-Responsive to Standard Treatment: A Case Series Study
Authors: Pasquale Claudio , Utyuzh Anatoliy , Mikhailova Maria Vladimirovna , Colombo Esteban , Amaroli Andrea
Published: August 2021

Diminished facial movement and marked facial asymmetry can lead to a consistent psychological burden. Bell′s palsy (BP) is one of the most common causes of facial nerve illness, which comes with unilateral acute facial paresis. Nowadays, no clear guidelines for treating BP are available. We carried out a case series study to test the efficacy of photobiomodulation (PBM) therapy in patients with BP non-responsive to standard treatment. The study was experimentally performed at the Department of Surgical and Diagnostic Sciences, University of Genoa (Genoa, Italy), in accordance with case report guidelines. Patients were referred to our department by colleagues for evaluation to be included in the case series because no consistent improvement was observed at least 3 months from the diagnosis of BP. All the patients interrupted their pharmacological therapy before the initiation of PBM therapy. PBM therapy (808 nm, 1 W irradiated in continuous-wave for 60 s on spot-size 1 cm2; 1 W/cm2; 60 J/cm2; and 60 J) was administered every 2 days until complete resolution. Evaluation of the House-Brackmann scale was performed before and after treatments. Fourteen patients were screened as eligible for the study. Patients were Caucasians (36% females and 64% males) with a mean age ± standard deviation of 56.07 ± 15.21 years. Eleven patients out of 14, who experienced BP a maximum of 6 months, completely recovered through PBM. The three patients that did not show improvement were those who had experienced BP for years. PBM could be a supportive therapy for the management of BP in patients non-responsive to standard treatment. However, randomized controlled trials are necessary to sustain our encouraging results, exclude bias, and better explain the boundary between the time from diagnosis and the recovery of BP through PBM therapy.
Singular Warped Beams Controlled by Tangent Phase Modulation
Authors: Funes Gustavo , Peters Eduardo , Anguita Jaime
Published: August 2021

We analyze the effect of spatial phase modulation using non-linear functions applied to singular warped beams to control their topological states and intensity distribution. Such beams are candidates for optical trapping and particle manipulation for their controllable pattern of intensities and singularities. We first simulate several kinds of warped beams to analyze their intensity profiles and propagation characteristics. Secondly, we experimentally validate the simulations and investigate the far-field profiles. By calculating the intensity gradients, we describe how these beams are qualified candidates for optical manipulation and trapping.
Association Mapping of Physiological and Morphological Traits Related to Crop Development under Contrasting Nitrogen Inputs in a Diverse Set of Potato Cultivars
Authors: Ospina Nieto Cesar A. , Lammerts van Bueren Edith T. , Allefs Sjefke , Vos Peter G. , van der Linden Gerard , Maliepaard Chris A. , Struik Paul C.
Published: August 2021

Ample nitrogen (N) is required for potato production, but its use efficiency is low. N supply strongly interacts with maturity type of the cultivar grown. We assessed whether variation among 189 cultivars grown with 75 or 185 kg available N/ha in 2 years would allow detecting quantitative trait loci (QTLs) for relevant traits. Using phenotypic data, we estimated various traits and carried out a genome-wide association study (GWAS) with kinship correction. Twenty-four traits and 10,747 markers based on single-nucleotide polymorphisms from a 20K Infinium array for 169 cultivars were combined in the analysis. N level affected most traits and their interrelations and influenced the detection of marker–trait associations; some were N-dependent, others were detected at both N levels. Ninety percent of the latter accumulated on a hotspot on Chromosome 5. Chromosomes 2 and 4 also contained regions with multiple associations. After correcting for maturity, the number of QTLs detected was much lower, especially of those common to both N levels; however, interestingly, the region on Chromosome 2 accumulated several QTLs. There is scope for marker-assisted selection for maturity, with the main purpose of improving characteristics within a narrow range of maturity types, in order to break the strong links between maturity type and traits like N use efficiency.
Green Synthesized Metal Oxide Nanoparticles Mediate Growth Regulation and Physiology of Crop Plants under Drought Stress
Authors: Alabdallah Nadiyah M. , Hasan Md. Mahadi , Hammami Inès , Alghamdi Azzah Ibrahim , Alshehri Dikhnah , Alatawi Hanan Ali
Published: August 2021

Metal oxide nanoparticles (MONPs) are regarded as critical tools for overcoming ongoing and prospective crop productivity challenges. MONPs with distinct physiochemical characteristics boost crop production and resistance to abiotic stresses such as drought. They have recently been used to improve plant growth, physiology, and yield of a variety of crops grown in drought-stressed settings. Additionally, they mitigate drought-induced reactive oxygen species (ROS) through the aggregation of osmolytes, which results in enhanced osmotic adaptation and crop water balance. These roles of MONPs are based on their physicochemical and biological features, foliar application method, and the applied MONPs concentrations. In this review, we focused on three important metal oxide nanoparticles that are widely used in agriculture: titanium dioxide (TiO2), zinc oxide (ZnO), and iron oxide (Fe3O4). The impacts of various MONPs forms, features, and dosages on plant growth and development under drought stress are summarized and discussed. Overall, this review will contribute to our present understanding of MONPs’ effects on plants in alleviating drought stress in crop plants.
Arabidopsis thaliana Response to Extracellular DNA: Self Versus Nonself Exposure
Authors: Chiusano Maria Luisa , Incerti Guido , Colantuono Chiara , Termolino Pasquale , Palomba Emanuela , Monticolo Francesco , Benvenuto Giovanna , Foscari Alessandro , Esposito Alfonso , Marti Lucia , de Lorenzo Giulia , Vega-Muñoz Isaac , Heil Martin , Carteni Fabrizio , Bonanomi Giuliano , Mazzoleni Stefano
Published: August 2021

The inhibitory effect of extracellular DNA (exDNA) on the growth of conspecific individuals was demonstrated in different kingdoms. In plants, the inhibition has been observed on root growth and seed germination, demonstrating its role in plant–soil negative feedback. Several hypotheses have been proposed to explain the early response to exDNA and the inhibitory effect of conspecific exDNA. We here contribute with a whole-plant transcriptome profiling in the model species Arabidopsis thaliana exposed to extracellular self- (conspecific) and nonself- (heterologous) DNA. The results highlight that cells distinguish self- from nonself-DNA. Moreover, confocal microscopy analyses reveal that nonself-DNA enters root tissues and cells, while self-DNA remains outside. Specifically, exposure to self-DNA limits cell permeability, affecting chloroplast functioning and reactive oxygen species (ROS) production, eventually causing cell cycle arrest, consistently with macroscopic observations of root apex necrosis, increased root hair density and leaf chlorosis. In contrast, nonself-DNA enters the cells triggering the activation of a hypersensitive response and evolving into systemic acquired resistance. Complex and different cascades of events emerge from exposure to extracellular self- or nonself-DNA and are discussed in the context of Damage- and Pathogen-Associated Molecular Patterns (DAMP and PAMP, respectively) responses.
Preparation and Characterization of Eco-Friendly Spent Coffee/ENR50 Biocomposite in Comparison to Carbon Black
Authors: Raju Gunasunderi , Khalid Mohammad , Shaban Mahmoud M. , Azahari Baharin
Published: August 2021

This study investigates the impact of spent coffee biochar (Biochar) compared to carbon black (CB) as a partial replacement for carbon black in epoxidized natural rubber (ENR). Particle size and elemental analysis were used to characterize the biochar and CB. Cure characteristics, tensile, thermal, and morphological properties on the effect of biochar and CB as filler were studied. It was found that incorporating 10 phr of spent coffee biochar could improve the composites’ tensile properties and thermal performance compared to carbon black. However, the addition of biochar significantly affects the maximum torque compared to CB and delays the vulcanization time. SEM study shows that biochar has a strong effect on the morphology of composite films. The FTIR graph reveals no substantial difference between compounds with biochar and CB. According to the thermal calorimetric study, the thermal stability of ENR-Biochar is higher than that of ENR-CB. Additionally, these findings suggest that the utilization of spent coffee as a sustainable biochar could be further explored, but little has been done in epoxidized natural rubber (ENR).
Synthesis, Characterization and Mechanical Properties of Novel Bio-Based Polyurethane Foams Using Cellulose-Derived Polyol for Chain Extension and Cellulose Citrate as a Thickener Additive
Authors: Maiuolo Loredana , Olivito Fabrizio , Algieri Vincenzo , Costanzo Paola , Jiritano Antonio , Tallarida Matteo Antonio , Tursi Antonio , Sposato Corradino , Feo Andrea , De Nino Antonio
Published: August 2021

A novel series of bio-based polyurethane composite foams was prepared, employing a cellulose-derived polyol for chain extension and cellulose-citrate as a thickener additive. The utilized polyol was obtained from the reduction reaction of cellulose-derived bio-oil through the use of sodium borohydride and iodine. Primarily, we produced both rigid and flexible polyurethane foams through chain extension of the prepolymers. Secondly, we investigated the role of cellulose citrate as a polyurethane additive to improve the mechanical properties of the realized composite materials. The products were characterized by FT-IR spectroscopy and their morphologies were analysed by SEM. Mechanical tests were evaluated to open new perspectives towards different applications.
Polymer-Based Additive Manufacturing: Process Optimisation for Low-Cost Industrial Robotics Manufacture
Authors: Walia Kartikeya , Khan Ahmed , Breedon Philip
Published: August 2021

The robotics design process can be complex with potentially multiple design iterations. The use of 3D printing is ideal for rapid prototyping and has conventionally been utilised in concept development and for exploring different design parameters that are ultimately used to meet an intended application or routine. During the initial stage of a robot development, exploiting 3D printing can provide design freedom, customisation and sustainability and ultimately lead to direct cost benefits. Traditionally, robot specifications are selected on the basis of being able to deliver a specific task. However, a robot that can be specified by design parameters linked to a distinctive task can be developed quickly, inexpensively, and with little overall risk utilising a 3D printing process. Numerous factors are inevitably important for the design of industrial robots using polymer-based additive manufacturing. However, with an extensive range of new polymer-based additive manufacturing techniques and materials, these could provide significant benefits for future robotics design and development.
Study of Different Chitosan/Sodium Carboxymethyl Cellulose Proportions in the Development of Polyelectrolyte Complexes for the Sustained Release of Clarithromycin from Matrix Tablets
Authors: Guarnizo-Herrero Víctor , Torrado-Salmerón Carlos , Torres Pabón Norma Sofía , Torrado Durán Guillermo , Morales Javier , Torrado-Santiago Santiago
Published: August 2021

This study investigated the combination of different proportions of cationic chitosan and anionic carboxymethyl cellulose (CMC) for the development of polyelectrolyte complexes to be used as a carrier in a sustained-release system. Analysis via scanning electron microscopy (SEM) Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffraction (PXRD) confirmed ionic interactions occur between the chitosan and carboxymethyl cellulose chains, which increases drug entrapment. The results of the dissolution study in acetate buffer (pH 4.2) showed significant increases in the kinetic profiles of clarithromycin for low proportions of chitosan/carboxymethyl cellulose tablets, while the tablets containing only chitosan had high relaxation of chitosan chains and disintegrated rapidly. The Korsmeyer–Peppas kinetic model for the different interpolymer complexes demonstrated that the clarithromycin transport mechanism was controlled by Fickian diffusion. These results suggest that the matrix tablets with different proportions of chitosan/carboxymethyl cellulose enhanced the ionic interaction and enabled the prolonged release of clarithromycin.
Micropatterned Fibrous Scaffold Produced by Using Template-Assisted Electrospinning Technique for Wound Healing Application
Authors: Norzain Norul Ashikin , Yu Zhi-Wei , Lin Wei-Chih , Su Hsing-Hao
Published: August 2021

This paper describes the fabrication of a structural scaffold consisting of both randomly oriented nanofibers and triangular prism patterns on the scaffold surface using a combination technique of electrospinning and collector templates. The polycaprolactone (PCL) nanofibers were electrospun over a triangular prism pattern mold, which acted as a template. The deposited scaffold was removed from the template to produce a standalone structural scaffold of three-dimensional micropatterned nanofibers. The fabricated structural scaffold was compared with flat randomly oriented nanofibers based on in vitro and in vivo studies. The in vitro study indicated that the structural scaffold demonstrated higher fibroblast cell proliferation, cell elongation with a 13.48 ± 2.73 aspect ratio and 70% fibroblast cell orientation compared with flat random nanofibers. Among the treatment groups, the structural scaffold escalated the wound closure to 92.17% on day 14. Histological staining of the healed wound area demonstrated that the structural scaffold exhibited advanced epithelization of the epidermal layer accompanied by mild inflammation. The proliferated fibroblast cells and collagen fibers in the structural scaffold appeared denser and arranged more horizontally. These results determined the potential of micropatterned scaffolds for stimulating cell behavior and their application for wound healing.
Effect of Position and Structure of the Terminal Moieties in the Side Group on the Liquid Crystal Alignment Behavior of Polystyrene Derivatives
Authors: Yang DaEun , Seo Kyutae , Kang Hyo
Published: August 2021

We synthesized a series of polystyrene derivatives containing various side groups, such as the 4-(tert-butyl)-phenoxymethyl, 3-(tert-butyl)-phenoxymethyl, 2-(tert-butyl)-phenoxymethyl, 4-cumyl-phenoxymethyl, and 4-trityl-phenoxymethyl groups, through a polymer modification reaction to examine the liquid crystal (LC) alignment of these derivatives. In general, the vertical LC alignment on polymer films can be affected by the position and structure of the terminal moiety of the polymer side group. For example, the LC cells fabricated with 4-(tert-butyl)-phenoxymethyl-substituted polystyrene having a tert-butyl moiety as a para-type attachment to the phenoxy groups of the polystyrene derivatives exhibited vertical LC alignment, whereas the LC cells prepared from 3-(tert-butyl)- and 2-(tert-butyl)-phenoxymethyl-substituted polystyrene films exhibited planar LC alignment. In addition, the LC cells fabricated from 4-cumyl- and 4-trityl-phenoxymethyl-substituted polystyrene films with additional phenyl rings in the side groups exhibited planar LC alignment, in contrast to the LC alignment of the (tert-butyl)-phenoxymethyl-substituted polystyrene series. The vertical LC orientation was well correlated with the surface energy of these polymer films. For example, vertical LC orientation, which mainly originates due to the nonpolar tertiary carbon moiety having bulky groups, was observed when the surface energy of the polymer was lower than 36.6 mJ/m2.
An Effective Package of Antioxidants for Avoiding Premature Failure in Polypropylene Random Copolymer Plastic Pipes under Hydrostatic Pressure and High Temperature
Authors: Blázquez-Blázquez Enrique , Lahoz Joaquín , Pérez Ernesto , Cerrada María L.
Published: August 2021

Pipes of polypropylene random (PP-R) copolymers are the best choice for hot- and cold-water networks. Validation of a severe test, accomplishing the ISO 1167 standard, is mandatory to assess their service lifetime expectancy. This work evaluates the behavior shown by three commercial pipes, either the original ones (new pipes) or after being subjected to a hydrostatic pressure test at elevated temperature (aged pipes). Several features with relevance for the final performance have been examined: crystalline characteristics, phase transitions in crystalline regions, effect of high temperature and pressure on these transitions, and oxidation induction time. Moreover, the presence of inorganic fillers, and the content of different antioxidants together with their depletion, have also been analyzed. Films from the new pipes were also prepared for replication of the different environments in order to achieve a better and complete understanding of the phase transitions in the crystalline regions and of the consumption of antioxidants. Distinct environments surrounded the inner and outer parts of the pipes exposed to the failure aging test at 110 °C: hot water and warm dry air, respectively. These features play a key role in the loss of additives and in the subsequent initiation of degradation. Even if the crystalline characteristics are appropriate in the polymeric matrix, the success of a pipe lies in the homogeneous dispersion of components for avoiding damage at interfacial properties, and in a correct package of antioxidants used in its formulation.
The Expression of UGT46A1 Gene and Its Effect on Silkworm Feeding
Authors: Song Wenting , Fan Yixuan , Zhu Feifei , Taha Rehab Hosny , Chen Keping
Published: August 2021

The silkworm, Bombyx mori, uses a complex olfactory system to determine whether the food is edible. As an odor degrading enzyme, UDP-glycosyltransferase (UGT) participates in the degradation of odor molecules in the olfactory system of the silkworm. By sequencing the whole genome of the silkworm NB and using comparative genomics methods, we found that UGT46A1 is unique in species that eat mulberry leaves. Bioinformatics shows that its function may be related to the feeding habits of the silkworm. In this study, it was found through quantitative real-time polymerase chain reaction (qRT-PCR) that UGT46A1 was highly expressed in the heads of silkworms, which was consistent with the conjecture that UGT46A1 was involved in silkworm olfactory recognition. RNA interference (RNAi) was used to knock down the expression of UGT46A1. By observing the silkworm’s tendency toward mulberry leaves and food selectivity, it was found that the silkworms that successfully knocked down the UGT46A1 gene altered their feeding habits and that their ability to find food was weakened, but they could eat more leaves of plants other than mulberry leaves. This evidence indicates that UGT46A1 may affect the silkworm’s feeding by influencing the olfactory system of the silkworm.
Spanish Fact-Checking Services: An Approach to Their Business Models
Authors: Esteban-Navarro Miguel-Ángel , Nogales-Bocio Antonia-Isabel , García-Madurga Miguel-Ángel , Morte-Nadal Tamara
Published: August 2021

The proliferation of fact-checking services is a fast-growing global phenomenon, especially in Western countries. These services are the response of journalism to disinformation, that has transformed a common internal procedure of journalistic work in the core of a business directed to the general public, also offered to the companies of mass media and social media. Literature review shows that the research on fact-checking has focused on the origin, funding, relationship with the media, procedures, and experiences related to politics and COVID-19. However, the ownership structure of the fact-checking services has been superficially analysed and the business model of these platforms has not yet been studied in detail and depth. The objective of this article is to identify and analyse the business model of the nine Spanish active fact-checking services through a documentary research of public information sources and the information that these services give about themselves. This paper explains their ownership structure and income provenance, from open information sources. The findings are that the fact-checking services that depend on media groups are no strangers to the trend of opacity usual in these groups, but in the case of fact-checking services that are born as initiatives of journalists, the trend towards transparency is, in the majority of cases, clear. However, the information provided by the Spanish fact-checking services is deficient and does not allow us to discover their business models, except in the case of Newtral and, to a certain extent, Maldita.
‘I Am an African’
Authors: Igboin Benson Ohihon
Published: August 2021

The question, who is an African? in the context of understanding African identity has biological, historical, cultural, religious, political, racial, linguistic, social, philosophical, and even geographical colourations. Scholars as well as commentators have continued to grapple with it as it has assumed a syncretistic or intersectional characterisation. The same applies to, “what is Africa?” because of the defined Western construct of its geography. This foray of concepts appears to be captured in ‘I am an African’, a treatise that exudes the telos of African past, present and the unwavering hope that the future of Africans and Africa is great in spite of the cynicism and loss of faith that the present seems to have foisted on the minds of many an African. Through a critical analysis, it is argued that African religion has a value that is capable of resolving the contentious identity crisis of an African.
Sustainable Survival: Resource Management Strategy in Micro and Small Enterprises in the Rubber Products Market in Poland during the COVID-19 Pandemic
Authors: Czainska Katarzyna , Sus Aleksandra , Thalassinos Eleftherios I.
Published: August 2021

The COVID-19 epidemic surprised economic operators around the world. The very existence of many businesses, and thus jobs, was at stake. However, one year after the WHO declared the outbreak a pandemic, contrary to the pessimistic forecasts of business analysts, some industries did not experience the predicted negative effects of the crisis. This article presents the results of a pilot study on micro and small enterprises in the rubber products industry in Poland during the COVID-19 pandemic, with the aim of analyzing the phenomenon of sustainable resource management that led not only to the survival of these enterprises but also to a significant increase in their turnover. Therefore, the purpose of the study was to analyze the key success factors of the indicated economic entities, with particular emphasis on the perspective of sustainable resource management and relationship management. On the basis of best research practices, a triangulation of research methods was applied (integrative literature review, computer-assisted telephone interviewing, and individual in-depth interview). A relationship was observed between the sustainable management of resources and the structure of the relationship network and the strength of its connections. In micro and small enterprises in the rubber products sector in Poland, sustainable resource management is related to the structure of the network of relations and the strength of connections in the network (relations/networking), as enterprises form a group of entities with a high level of loyalty, especially between the suppliers and buyers of raw materials. The formulated conclusions will become the basis for further in-depth research that can be conducted (a) in the same group of respondents, but using a representative research group, (b) in the same industry among a group of large enterprises, and (c) in a group of small and medium-sized enterprises (SMEs) from other industries.
Determinants Affecting Profitability of State-Owned Commercial Banks: Case Study of China
Authors: Koroleva Ekaterina , Jigeer Shawuya , Miao Anqi , Skhvediani Angi
Published: August 2021

The study examines the relationship between internal determinants, external determinants and the profitability of state-owned commercial banks. We use pooled regression, fixed effect, and random effect models on the case of the top five Chinese state-owned commercial banks from 2007 to 2019. The results show that internal factors, measured by size, credit quality, and liquidity, significantly positively influence banks’ profitability. State-owned banks that have larger sizes, higher credit quality, and higher liquidity have accordingly higher profitability than other banks. On the contrary, the external factor, measured by the natural logarithm of GDP, negatively influences banks’ profitability. The decrease in GDP leads to higher profitability of state-owned commercial banks in China. Our results provide insight into the profitability of state-owned commercial banks, considering the latest changes in the Chinese banking industry.
Soil Moisture Estimates in a Grass Field Using Sentinel-1 Radar Data and an Assimilation Approach
Authors: Montaldo Nicola , Fois Laura , Corona Roberto
Published: August 2021

The new constellation of synthetic aperture radar (SAR) satellite, Sentinel-1, provides images at a high spatial resolution (up to 10 m) typical of radar sensors, but also at high time resolutions (6–12 revisit days), representing a major advance for the development of operational soil moisture mapping at a plot scale. Our objective was to develop and test an operational approach to assimilate Sentinel 1 observations in a land surface model, and to demonstrate the potential of the use of the new satellite sensors in soil moisture predictions in a grass field. However, for soil moisture retrievals from Sentinel 1 observations in grasslands, there is still the need to identify robust and parsimonious solutions, accounting for the effects of vegetation attenuation and their seasonal variability. In a grass experimental site in Sardinia, where field measurements of soil moisture were available for the 2016–2018 period, three common retrieval methods have been compared to estimate soil moisture from Sentinel 1 data, with increasing complexity and physical interpretation of the processes: the empirical change detection method, the semi-empirical Dubois model, and the physically-based Fung model. In operational approaches for soil moisture mapping from remote sensing, the parameterization simplification of soil moisture retrieval techniques is encouraged, looking for parameter estimates without a priori information. We have proposed a simplified approach for estimating a key parameter of retrieval methods, the surface roughness, from the normalized difference vegetation index (NDVI) derived by simultaneous Sentinel 2 optical observations. Soil moisture was estimated better using the proposed approach and the Dubois model than by using the other methods, which accounted vegetation effects through the common water cloud model. Furthermore, we successfully merged radar-based soil moisture observations and a land surface model, through a data assimilation approach based on the Ensemble Kalman filter, providing robust predictions of soil moisture.
Comparison of Multi-Year Reanalysis, Models, and Satellite Remote Sensing Products for Agricultural Drought Monitoring over South Asian Countries
Authors: Shahzaman Muhammad , Zhu Weijun , Ullah Irfan , Mustafa Farhan , Bilal Muhammad , Ishfaq Shazia , Nisar Shazia , Arshad Muhammad , Iqbal Rashid , Aslam Rana Waqar
Published: August 2021

The substantial reliance of South Asia (SA) to rain-based agriculture makes the region susceptible to food scarcity due to droughts. Previously, most research on SA has emphasized the meteorological aspects with little consideration of agrarian drought impressions. The insufficient amount of in situ precipitation data across SA has also hindered thorough investigation in the agriculture sector. In recent times, models, satellite remote sensing, and reanalysis products have increased the amount of data. Hence, soil moisture, precipitation, terrestrial water storage (TWS), and vegetation condition index (VCI) products have been employed to illustrate SA droughts from 1982 to 2019 using a standardized index/anomaly approach. Besides, the relationships of these products towards crop production are evaluated using the annual national production of barley, maize, rice, and wheat by computing the yield anomaly index (YAI). Our findings indicate that MERRA-2, CPC, FLDAS (soil moisture), GPCC, and CHIRPS (precipitation) are alike and constant over the entire four regions of South Asia (northwest, southwest, northeast, and southeast). On the other hand, GLDAS and ERA5 remain poor when compared to other soil moisture products and identified drought conditions in regions one (northwest) and three (northeast). Likewise, TWS products such as MERRA-2 TWS and GRACE TWS (2002–2014) followed the patterns of ERA5 and GLDAS and presented divergent and inconsistent drought patterns. Furthermore, the vegetation condition index (VCI) remained less responsive in regions three (northeast) and four (southeast) only. Based on annual crop production data, MERRA-2, CPC, FLDAS, GPCC, and CHIRPS performed fairly well and indicated stronger and more significant associations (0.80 to 0.96) when compared to others. Thus, the current outcomes are imperative for gauging the deficient amount of data in the SA region, as they provide substitutes for agricultural drought monitoring.
On the Value of Sentinel-1 InSAR Coherence Time-Series for Vegetation Classification
Authors: Nikaein Tina , Iannini Lorenzo , Molijn Ramses A. , Lopez-Dekker Paco
Published: August 2021

Synthetic aperture radar (SAR) acquisitions are mainly deemed suitable for mapping dynamic land-cover and land-use scenarios due to their timeliness and reliability. This particularly applies to Sentinel-1 imagery. Nevertheless, the accurate mapping of regions characterized by a mixture of crops and grasses can still represent a challenge. Radar time-series have to date mainly been exploited through backscatter intensities, whereas only fewer contributions have focused on analyzing the potential of interferometric information, intuitively enhanced by the short revisit. In this paper, we evaluate, as primary objective, the added value of short-temporal baseline coherences over a complex agricultural area in the São Paulo state, cultivated with heterogeneously (asynchronously) managed annual crops, grasses for pasture and sugarcane plantations. We also investigated the sensitivity of the radar information to the classification methods as well as to the data preparation and sampling practices. Two supervised machine learning methods—namely support vector machine (SVM) and random forest (RF)—were applied to the Sentinel-1 time-series at the pixel and field levels. The results highlight that an improvement of 10 percentage points (p.p.) in the classification accuracy can be achieved by using the coherence in addition to the backscatter intensity and by combining co-polarized (VV) and cross-polarized (VH) information. It is shown that the largest contribution in class discrimination is brought during winter, when dry vegetation and bare soils can be expected. One of the added values of coherence was indeed identified in the enhanced sensitivity to harvest events in a small but significant number of cases.
Spatiotemporal Characteristics of the Water Quality and Its Multiscale Relationship with Land Use in the Yangtze River Basin
Authors: Wu Jian , Zeng Sidong , Yang Linhan , Ren Yuanxin , Xia Jun
Published: August 2021

The spatiotemporal characteristics of river water quality are the key indicators for ecosystem health evaluation in basins. Land use patterns, as one of the main driving forces of water quality change, affect stream water quality differently with the variations in the spatiotemporal scales. Thus, quantitative analysis of the relationship between different land cover types and river water quality contributes to a better understanding of the effects of land cover on water quality, the landscape planning of water quality protection, and integrated water resources management. Based on water quality data of 2006–2018 at 18 typical water quality stations in the Yangtze River basin, this study analyzed the spatial and temporal variation characteristics of water quality by using the single-factor water quality identification index through statistical analysis. Furthermore, the Spearman correlation analysis method was adopted to quantify the spatial-scale and temporal-scale effects of various land uses, including agricultural land (AL), forest land (FL), grassland (GL), water area (WA), and construction land (CL), on the stream water quality of dissolved oxygen (DO), chemical oxygen demand (CODMn), and ammonia (NH3-N). The results showed that (1) in terms of temporal variation, the water quality of the river has improved significantly and the tributaries have improved more than the main rivers; (2) in the spatial variation respect, the water quality pollutants in the tributaries are significantly higher than those in the main stream, and the concentration of pollutants increases with the decrease of the distance from the estuary; and (3) the correlation between DO and land use is low, while that between NH3-N, CODMn, and land use is high. CL and AL have a negative effect on water quality, while FL and GL have a purifying effect on water quality. In particular, AL and CL have a significant positive correlation with pollutants in water. Compared with NH3-N, CODMn has a higher correlation with land use at a larger scale. The results highlight the spatial scale and seasonal dependence of land use on water quality, which can provide a scientific basis for land management and seasonal pollution control.
Studying a Subsiding Urbanized Area from a Multidisciplinary Perspective: The Inner Sector of the Sarno Plain (Southern Apennines, Italy)
Authors: Valente Ettore , Allocca Vincenzo , Riccardi Umberto , Camanni Giovanni , Di Martire Diego
Published: August 2021

Defining the origin of ground deformation, which can be a very challenging task, may be approached through several investigative techniques. Ground deformation can originate in response to both natural (e.g., tectonics) and anthropic (e.g., groundwater pumping) contributions. These may either act simultaneously or be somewhat correlated in space and time. For example, the location of structurally controlled basins may be the locus of enhanced human-induced subsidence. In this paper, we investigate the natural and anthropic contributions to ground deformation in the urbanized area of the inner Sarno plain, in the Southern Apennines. We used a multidisciplinary approach based on the collection and analysis of a combination of geomorphological, stratigraphical, structural, hydrogeological, GPS, and DInSAR datasets. Geomorphological, stratigraphical, and structural data suggested the occurrence of a graben-like depocenter, the Sarno basin, bounded by faults with evidence of activity in the last 39 ka. Geodetic data indicated that the Sarno basin also experienced ground deformation (mostly subsidence) in the last 30 years, with a possible anthropogenic contribution due to groundwater pumping. Hydrogeological data suggested that a significant portion of the subsidence detected by geodetic data can be ascribed to groundwater pumping from the alluvial plain aquifer, rather than to a re-activation of faults in the last 30 years. Our interpretation suggested that a positive feedback exists between fault activity and the location of area affected by human-induced subsidence. In fact, fault activity caused the accumulation of poorly consolidated deposits within the Sarno basin, which enhanced groundwater-induced subsidence. The multidisciplinary approach used here was proven to be successful within the study area and could therefore be an effective tool for investigating ground deformation in other urbanized areas worldwide.
High Wind Speed Inversion Model of CYGNSS Sea Surface Data Based on Machine Learning
Authors: Zhang Yun , Yin Jiwei , Yang Shuhu , Meng Wanting , Han Yanling , Yan Ziyu
Published: August 2021

In response to the deficiency of the detection capability of traditional remote sensing means (scatterometer, microwave radiometer, etc.) for high wind speed above 25 m/s, this paper proposes a GNSS-R technique combined with a machine learning method to invert high wind speed at sea surface. The L1-level satellite-based data from the Cyclone Global Navigation Satellite System (CYGNSS), together with the European Centre for Medium-Range Weather Forecasts (ECMWF) and the National Centers for Environmental Prediction (NCEP) data, constitute the original sample set, which is processed and trained with Support Vector Regression (SVR), the combination of Principal Component Analysis (PCA) and SVR (PCA-SVR), and Convolutional Neural Network (CNN) methods, respectively, to finally construct a sea surface high wind speed inversion model. The three models for high wind speed inversion are certified by the test data collected during Typhoon Bavi in 2020. The results show that all three machine learning models can be used for high wind speed inversion on sea surface, among which the CNN method has the highest inversion accuracy with a mean absolute error of 2.71 m/s and a root mean square error of 3.80 m/s. The experimental results largely meet the operational requirements for high wind speed inversion accuracy.
Comparative Evaluation of Algorithms for Leaf Area Index Estimation from Digital Hemispherical Photography through Virtual Forests
Authors: Liu Jing , Li Longhui , Akerblom Markku , Wang Tiejun , Skidmore Andrew , Zhu Xi , Heurich Marco
Published: August 2021

The in situ leaf area index (LAI) measurement plays a vital role in calibrating and validating satellite LAI products. Digital hemispherical photography (DHP) is a widely used in situ forest LAI measurement method. There have been many software programs encompassing a variety of algorithms to estimate LAI from DHP. However, there is no conclusive study for an accuracy comparison among them, due to the difficulty in acquiring forest LAI reference values. In this study, we aim to use virtual (i.e., computer-simulated) broadleaf forests for the accuracy assessment of LAI algorithms in commonly used LAI software programs. Three commonly used DHP programs, including Can_Eye, CIMES, and Hemisfer, were selected since they provide estimates of both effective LAI and true LAI. Individual tree models with and without leaves were first reconstructed based on terrestrial LiDAR point clouds. Various stands were then created from these models. A ray-tracing technique was combined with the virtual forests to model synthetic DHP, for both leaf-on and leaf-off conditions. Afterward, three programs were applied to estimate PAI from leaf-on DHP and the woody area index (WAI) from leaf-off DHP. Finally, by subtracting WAI from PAI, true LAI estimates from 37 different algorithms were achieved for evaluation. The performance of these algorithms was compared with pre-defined LAI and PAI values in the virtual forests. The results demonstrated that without correcting for the vegetation clumping effect, Can_Eye, CIMES, and Hemisfer could estimate effective PAI and effective LAI consistent with each other (R2 > 0.8, RMSD < 0.2). After correcting for the vegetation clumping effect, there was a large inconsistency. In general, Can_Eye more accurately estimated true LAI than CIMES and Hemisfer (with R2 = 0.88 > 0.72, 0.49; RMSE = 0.45 < 0.7, 0.94; nRMSE = 15.7% < 24.21%, 32.81%). There was a systematic underestimation of PAI and LAI using Hemisfer. The most accurate algorithm for estimating LAI was identified as the P57 algorithm in Can_Eye which used the 57.5° gap fraction inversion combined with the finite-length averaging clumping correction. These results demonstrated the inconsistency of LAI estimates from DHP using different algorithms. It highlights the importance and provides a reference for standardizing the algorithm protocol for in situ forest LAI measurement using DHP.
Profiling of Dust and Urban Haze Mass Concentrations during the 2019 National Day Parade in Beijing by Polarization Raman Lidar
Authors: Wang Zhuang , Liu Cheng , Dong Yunsheng , Hu Qihou , Liu Ting , Zhu Yizhi , Xing Chengzhi
Published: August 2021

The polarization–Raman Lidar combined sun photometer is a powerful method for separating dust and urban haze backscatter, extinction, and mass concentrations. The observation was performed in Beijing during the 2019 National Day parade, the particle depolarization ratio at 532 nm and Lidar ratio at 355 nm are 0.13 ± 0.05 and 52 ± 9 sr, respectively. It is the typical value of a mixture of dust and urban haze. Here we quantify the contributions of cross-regional transported natural dust and urban haze mass concentrations to Beijing’s air quality. There is a significant correlation between urban haze mass concentrations and surface PM2.5 (R = 0.74, p < 0.01). The contributions of local emissions to air pollution during the 2019 National Day parade were insignificant, mainly affected by regional transport, including urban haze in North China plain and Guanzhong Plain (Hebei, Tianjin, Shandong, and Shanxi), and dust aerosol in Mongolia regions and Xinjiang. Moreover, the trans-regional transmission of natural dust dominated the air pollution during the 2019 National Day parade, with a relative contribution to particulate matter mass concentrations exceeding 74% below 4 km. Our results highlight that controlling anthropogenic emissions over regional scales and focusing on the effects of natural dust is crucial and effective to improve Beijing’s air quality.