bluuebunny/crossref_metadata_2025 huggingface dataset:
Valorization of Polysaccharides From Benincasa hispida: Physicochemical, Moisturizing, and Antioxidant Skincare Properties
Authors: Wang Qian , Yang Xiaoyan , Zhu Changwei , Liu Guodong , Han Weili , Sun Yujun , Qian Lisheng
Published: June 2022

Benincasa hispida Cogn. (B. hispida) is a popular vegetable in China, and studies have been reported on B. hispida polysaccharides (BPS) preparation. However, few studies have been reported on its physicochemical and skincare properties. In this study, we analyzed the physicochemical properties of BPS, free radical scavenging capability, moisturizing and antioxidant activities in vitro and in vivo, respectively. Our results show that BPS was an inhomogeneous acidic polysaccharide that could scavenge a variety of free radicals. Also, BPS had a good moisturizing and antioxidant capability both in vitro and in vivo. Specifically, BPS could alter some key antioxidant enzyme activities and pro-inflammatory factor levels via activating the NRF2/HO-1 pathway, thereby preventing H2O2-induced reactive oxygen species (ROS) production and apoptosis of HDF-1 cells. Our results suggest that BPS exhibited favorable moisturizing and anti-aging properties and might be an attractive candidate for the development of anti-aging skincare products.
Design and Analysis of Novel Folded Optical Multi-Pass Cell
Authors: Cheng Gang , Cao Ya-Nan , Tian Xing , Chen Jia-Jin , Wang Jing-Jing
Published: June 2022

A novel folded multi-pass cell consisting of three non-coaxial mirrors (spherical mirror or plane mirror) is proposed for laser spectroscopy. Three mirrors of the folded multi-pass cell can arrange in V-shape to form a stable non-coaxial multi-pass cell. Furthermore, in order to research the stability of the multi-pass cell under off-axis mirror’s astigmatism circumstance, an equivalent coaxial multi-pass cell and modified ABCD matrix model for the spot pattern of the folded multi-pass cell is proposed, by which a series of the detailed numerical calculations were implemented to analyze the optical path length of the multi-pass cell. Many spot patterns obtained with a high fill factor improve the utilization efficiency of the surface of the mirror and produce a longer total optical path length. The several typical types of folded multi-pass cells consisting of the different mirrors and base lengths were selected to demonstrate the cell’s self-consistent condition and power for a longer-optical path length. Three effective optical path lengths of 49.6, 97.6 and 173.6 m were obtained, respectively.
Multi-Beam Large Fundamental Mode Neodymium Glass Regenerative Amplifier With Uniform Performance
Authors: Gao Song , Xie Xudong , Tang Jun , Fan Chen , Fu Xuejun , Chen Zhifei , Yao Ke
Published: June 2022

In this study, the designing method of multi-beam regenerative amplifiers with the repetitive rate was proposed and demonstrated. To obtain multi-beam regenerative amplifiers with uniform performance, the disparities in output energy, energy stability, and mode size were analyzed, and the detailed optimizing method was presented. With the designs, eight-beam regenerative amplifiers were developed. The output performances of eight-beam regenerative amplifiers were uniform. The output energies were in the range of 25.4–28.8 mJ, and the energy stabilities over two hours were in the range of 2.4%–5.1% (PV) and 0.3%–0.9% (RMS).
Anemia Increases Oxygen Extraction Fraction in Deep Brain Structures but Not in the Cerebral Cortex
Authors: Shen Jian , Miao Xin , Vu Chau , Xu Botian , González-Zacarías Clio , Nederveen Aart J. , Wood John C.
Published: June 2022

Sickle cell disease (SCD) is caused by a single amino acid mutation in hemoglobin, causing chronic anemia and neurovascular complications. However, the effects of chronic anemia on oxygen extraction fraction (OEF), especially in deep brain structures, are less well understood. Conflicting OEF values have been reported in SCD patients, but have largely attributed to different measurement techniques, faulty calibration, and different locations of measurement. Thus, in this study, we investigated the reliability and agreement of two susceptibility-based methods, quantitative susceptibility mapping (QSM) and complex image summation around a spherical or a cylindrical object (CISSCO), for OEF measurements in internal cerebral vein (ICV), reflecting oxygen saturation in deep brain structures. Both methods revealed that SCD patients and non-sickle anemia patients (ACTL) have increased OEF in ICV (42.6% ± 5.6% and 30.5% ± 3.6% in SCD by CISSCO and QSM respectively, 37.0% ± 4.1% and 28.5% ± 2.3% in ACTL) compared with controls (33.0% ± 2.3% and 26.8% ± 1.8%). OEF in ICV varied reciprocally with hematocrit (r2 = 0.92, 0.53) and oxygen content (r2 = 0.86, 0.53) respectively. However, an opposite relationship was observed for OEF measurements in sagittal sinus (SS) with the widely used T2-based oximetry, T2-Relaxation-Under-Spin-Tagging (TRUST), in the same cohorts (31.2% ± 6.6% in SCD, 33.3% ± 5.9% in ACTL and 36.8% ± 5.6% in CTL). Importantly, we demonstrated that hemoglobin F and other fast moving hemoglobins decreased OEF by TRUST and explained group differences in sagittal sinus OEF between anemic and control subjects. These data demonstrate that anemia causes deep brain hypoxia in anemia subjects with concomitant preservation of cortical oxygenation, as well as the key interaction of the hemoglobin dissociation curve and cortical oxygen extraction.
Small Object Detection via Pixel Level Balancing With Applications to Blood Cell Detection
Authors: Hu Bin , Liu Yang , Chu Pengzhi , Tong Minglei , Kong Qingjie
Published: June 2022

Object detection technology has been widely used in medical field, such as detecting the images of blood cell to count the changes and distribution for assisting the diagnosis of diseases. However, detecting small objects is one of the most challenging and important problems especially in medical scenarios. Most of the objects in medical images are very small but influential. Improving the detection performance of small objects is a very meaningful topic for medical detection. Current researches mainly focus on the extraction of small object features and data augmentation for small object samples, all of these researches focus on extracting the feature space of small objects better. However, in the training process of a detection model, objects of different sizes are mixed together, which may interfere with each other and affect the performance of small object detection. In this paper, we propose a method called pixel level balancing (PLB), which takes into account the number of pixels contained in the detection box as an impact factor to characterize the size of the inspected objects, and uses this as an impact factor. The training loss of each object of different size is adjusted by a weight dynamically, so as to improve the accuracy of small object detection. Finally, through experiments, we demonstrate that the size of objects in object detection interfere with each other. So that we can improve the accuracy of small object detection through PLB operation. This method can perform well with blood cell detection in our experiments.
Cepstral Analysis for Scoring the Quality of Electrocardiograms for Heart Rate Variability
Authors: Castiglioni Paolo , Parati Gianfranco , Faini Andrea
Published: June 2022

Mobile-health solutions based on heart rate variability often require electrocardiogram (ECG) recordings by inexperienced operators or real-time automatic analyses of long-term recordings by wearable devices in free-moving individuals. In this context, it is useful to associate a quality index with the ECG, scoring the adequacy of the recording for heart rate variability to identify noise or arrhythmias. Therefore, this work aims to propose and validate a computational method for assessing the adequacy of single-lead ECGs for heart rate variability analysis that may run in real time on wearable systems with low computational power. The method quantifies the ECG pseudo-periodic structure employing cepstral analysis. The cepstrum (spectrum of log-spectrum) is estimated on a running ECG window of 10 s before and after “liftering” (filtering in the cepstral domain) to remove slower noise components. The ECG periodicity generates a dominant peak in the liftered cepstrum at the “quefrency” of the mean cardiac interval. The Cepstral Quality Index (CQI) is the ratio between the cepstral-peak power and the total power of the unliftered cepstrum. Noises and arrhythmias reduce the relative power of the cepstral peak decreasing CQI. We analyzed a public dataset of 6072 single-lead ECGs manually classified in normal rhythm or inadequate for heart rate variability analysis because of noise or atrial fibrillation, and the CQI = 47% cut-off identified the inadequate recordings with 79% sensitivity and 85% specificity. We showed that the performance is independent of the lead considering a public dataset of 1,000 12-lead recordings with quality classified as “acceptable” or “unacceptable” by visual inspection. Thus, the cepstrum describes the ECG periodic structure effectively and concisely and CQI appears to be a robust score of the adequacy of ECG recording for heart rate variability analysis, evaluable in real-time on wearable devices.
Oligomerization and Spatial Distribution of Kvβ1.1 and Kvβ2.1 Regulatory Subunits
Authors: Roig Sara R. , Cassinelli Silvia , Zeug Andre , Ponimaskin Evgeni , Felipe Antonio
Published: June 2022

Members of the regulatory Kvβ family modulate the kinetics and traffic of voltage-dependent K+ (Kv) channels. The crystal structure of Kv channels associated with Kvβ peptides suggests a α4/β4 composition. Although Kvβ2 and Kvβ1 form heteromers, evidence supports that only Kvβ2.1 forms tetramers in the absence of α subunits. Therefore, the stoichiometry of the Kvβ oligomers fine-tunes the activity of hetero-oligomeric Kv channel complexes. We demonstrate that Kvβ subtypes form homo- and heterotetramers with similar affinities. The Kvβ1.1/Kvβ2.1 heteromer showed an altered spatial distribution in lipid rafts, recapitulating the Kvβ1.1 pattern. Because Kvβ2 is an active partner of the Kv1.3-TCR complex at the immunological synapse (IS), an association with Kvβ1 would alter this location, shaping the immune response. Differential regulation of Kvβs influences the traffic and architecture of the Kvβ heterotetramer, modulating Kvβ-dependent physiological responses.
Integrated Transcriptomics and Widely Targeted Metabolomics Analyses Provide Insights Into Flavonoid Biosynthesis in the Rhizomes of Golden Buckwheat (Fagopyrum cymosum)
Authors: Huang Juan , Wang Luyuan , Tang Bin , Ren Rongrong , Shi Taoxiong , Zhu Liwei , Deng Jiao , Liang Chenggang , Wang Yan , Chen Qingfu
Published: June 2022

Golden buckwheat (Fagopyrum cymosum) is used in Traditional Chinese Medicine. It has received attention because of the high value of its various medicinal and nutritional metabolites, especially flavonoids (catechin and epicatechin). However, the metabolites and their encoding genes in golden buckwheat have not yet been identified in the global landscape. This study performed transcriptomics and widely targeted metabolomics analyses for the first time on rhizomes of golden buckwheat. As a result, 10,191 differentially expressed genes (DEGs) and 297 differentially regulated metabolites (DRMs) were identified, among which the flavonoid biosynthesis pathway was enriched in both transcriptome and metabolome. The integration analyses of the transcriptome and the metabolome revealed a network related to catechin, in which four metabolites and 14 genes interacted with each other. Subsequently, an SG5 R2R3-MYB transcription factor, named FcMYB1, was identified as a transcriptional activator in catechin biosynthesis, as it was positively correlated to eight flavonoid biosynthesis genes in their expression patterns and was directly bound to the promoters of FcLAR2 and FcF3'H1 by yeast one hybrid analysis. Finally, a flavonoid biosynthesis pathway was proposed in the rhizomes of golden buckwheat, including 13 metabolites, 11 genes encoding 9 enzymes, and 1 MYB transcription factor. The expression of 12 DEGs were validated by qRT-PCR, resulting in a good agreement with the Pearson R ranging from 0.83 to 1. The study provided a comprehensive flavonoid biosynthesis and regulatory network of golden buckwheat.
Grain Transcriptome Dynamics Induced by Heat in Commercial and Traditional Bread Wheat Genotypes
Authors: Tomás Diana , Viegas Wanda , Silva Manuela
Published: June 2022

High temperature (HT) events have negative impact on wheat grains yield and quality. Transcriptome profiles of wheat developing grains of commercial genotypes (Antequera and Bancal) and landraces (Ardito and Magueija) submitted to heatwave-like treatments during grain filling were evaluated. Landraces showed significantly more differentially expressed genes (DEGs) and presented more similar responses than commercial genotypes. DEGs were more associated with transcription and RNA and protein synthesis in Antequera and with metabolism alterations in Bancal and landraces. Landraces upregulated genes encoding proteins already described as HT responsive, like heat shock proteins and cupins. Apart from the genes encoding HSP, two other genes were upregulated in all genotypes, one encoding for Adenylate kinase, essential for the cellular homeostasis, and the other for ferritin, recently related with increased tolerance to several abiotic stress in Arabidopsis. Moreover, a NAC transcription factor involved in plant development, known to be a negative regulator of starch synthesis and grain yield, was found to be upregulated in both commercial varieties and downregulated in Magueija landrace. The detected diversity of molecular processes involved in heat response of commercial and traditional genotypes contribute to understand the importance of genetic diversity and relevant pathways to cope with these extreme events.
Reticulate Evolution in the Western Mediterranean Mountain Ranges: The Case of the Leucanthemopsis Polyploid Complex
Authors: Tomasello Salvatore , Oberprieler Christoph
Published: June 2022

Polyploidization is one of the most common speciation mechanisms in plants. This is particularly relevant in high mountain environments and/or in areas heavily affected by climatic oscillations. Although the role of polyploidy and the temporal and geographical frameworks of polyploidization have been intensively investigated in the alpine regions of the temperate and arctic biomes, fewer studies are available with a specific focus on the Mediterranean region. Leucanthemopsis (Asteraceae) consists of six to ten species with several infraspecific entities, mainly distributed in the western Mediterranean Basin. It is a polyploid complex including montane, subalpine, and strictly alpine lineages, which are locally distributed in different mountain ranges of Western Europe and North Africa. We used a mixed approach including Sanger sequencing and (Roche-454) high throughput sequencing of amplicons to gather information from single-copy nuclear markers and plastid regions. Nuclear regions were carefully tested for recombinants/PCR artifacts and for paralogy. Coalescent-based methods were used to infer the number of polyploidization events and the age of formation of polyploid lineages, and to reconstruct the reticulate evolution of the genus. Whereas the polyploids within the widespread Leucanthemopsis alpina are autopolyploids, the situation is more complex among the taxa endemic to the western Mediterranean. While the hexaploid, L. longipectinata, confined to the northern Moroccan mountain ranges (north–west Africa), is an autopolyploid, the Iberian polyploids are clearly of allopolyploid origins. At least two different polyploidization events gave rise to L. spathulifolia and to all other tetraploid Iberian taxa, respectively. The formation of the Iberian allopolyploids took place in the early Pleistocene and was probably caused by latitudinal and elevational range shifts that brought into contact previously isolated Leucanthemopsis lineages. Our study thus highlights the importance of the Pleistocene climatic oscillations and connected polyploidization events for the high plant diversity in the Mediterranean Basin.
Epigenetic and Phenotypic Responses to Experimental Climate Change of Native and Invasive Carpobrotus edulis
Authors: Campoy Josefina G. , Sobral Mar , Carro Belén , Lema Margarita , Barreiro Rodolfo , Retuerto Rubén
Published: June 2022

Despite the recent discoveries on how DNA methylation could help plants to adapt to changing environments, the relationship between epigenetics and climate change or invasion in new areas is still poorly known. Here, we investigated, through a field experiment, how the new expected climate scenarios for Southern Europe, i.e., increased temperature and decreased rainfall, might affect global DNA methylation in relation to phenotypic variation in individuals of clonal plant, Carpobrotus edulis, from its native (Southern African) and invaded (northwestern Iberian Peninsula) area. Our results showed that changes in temperature and rainfall induced phenotypic but not global DNA methylation differences among plants, and the climatic effects were similar for plants coming from the native or invaded areas. The individuals from the Iberian Peninsula showed higher levels of global methylation than their native counterparts from South Africa. We also observed differences between natives and invasive phenotypes in traits related to the pattern of biomass partitioning and to the strategies for water uptake and use and found an epigenetic contribution to phenotypic changes in some leaf traits, especially on the nitrogen isotopic composition. We conclude that the increased temperature and decreased rainfall projected for Southern Europe during the course of the twenty-first century may foster phenotypic changes in C. edulis, possibly endowing this species with a higher ability to successful cope the rapid environmental shifts. The epigenetic and phenotypic divergence that we observed between native and invasive plants suggests an intraspecific functional variation during the process of invasion. This result could indicate that phenotypic plasticity and global DNA methylation are related to the colonization of new habitats. Our findings reinforce the importance of epigenetic plasticity on rapid adaptation of invasive clonal plants.
The Diversity Distribution and Climatic Niche of Samara Species in China
Authors: Du Yanjun , Zhao Yuan , Dong Shupeng , Chen Guoke , Wang Xinyang , Ma Keping
Published: June 2022

Studying the distribution of samara species is of ecological and economic significance. This information helps us with understanding species dispersal mechanisms, evaluating the risk of invasive species, and the management of ecological forests. However, limited research has explored, on a large scale, the geographic distribution of samara species and their influential abiotic factors. Here, we use the distribution data of 835 vascular samara species and growth form data to explore their geographic patterns in China and the environmental determinants. We divided China into 984 grid cells and examined the relationship between the proportion of samara species and climate variables using both ordinary and spatial linear regressions for each grid cell. Total samara species richness is higher in southern China in low altitude regions and the proportion of woody samara species is significantly higher than that of herbaceous samara species. The proportion of woody samara species is higher in the northeast regions where precipitation is sufficient, winters are dry and mild, and temperature seasonality and land surface relief degree values are high. Annual precipitation and temperature seasonality are the most important climatic drivers for the distribution of woody samara species. In contrast, herbaceous samara species prefer to distribute to the areas where climate is warm and dry but have higher temperature seasonality. Temperature related variables (mean annual temperature, mean diurnal range, and temperature seasonality) are the most important drivers for the distribution of herbaceous samara species. Samara species can better adapt to climatic regions with large temperature fluctuations and dry winters. The present distribution patterns of samara species are formed by the combined adaptation of fruit traits and growth form to climate. This work contributes to predictions of the global distribution of samara species under future climate change scenarios and conservation and management for the samara species.
Correlations Between the Metabolome and the Endophytic Fungal Metagenome Suggests Importance of Various Metabolite Classes in Community Assembly in Horseradish (Armoracia rusticana, Brassicaceae) Roots
Authors: Plaszkó Tamás , Szűcs Zsolt , Cziáky Zoltán , Ács-Szabó Lajos , Csoma Hajnalka , Géczi László , Vasas Gábor , Gonda Sándor
Published: June 2022

The plant microbiome is an increasingly intensive research area, with significance in agriculture, general plant health, and production of bioactive natural products. Correlations between the fungal endophytic communities and plant chemistry can provide insight into these interactions, and suggest key contributors on both the chemical and fungal side. In this study, roots of various horseradish (Armoracia rusticana) accessions grown under the same conditions were sampled in two consecutive years and chemically characterized using a quality controlled, untargeted metabolomics approach by LC-ESI-MS/MS. Sinigrin, gluconasturtiin, glucoiberin, and glucobrassicin were also quantified. Thereafter, a subset of roots from eight accessions (n = 64) with considerable chemical variability was assessed for their endophytic fungal community, using an ITS2 amplicon-based metagenomic approach using a custom primer with high coverage on fungi, but no amplification of host internal transcribed spacer (ITS). A set of 335 chemical features, including putatively identified flavonoids, phospholipids, peptides, amino acid derivatives, indolic phytoalexins, a glucosinolate, and a glucosinolate downstream product was detected. Major taxa in horseradish roots belonged to Cantharellales, Glomerellales, Hypocreales, Pleosporales, Saccharomycetales, and Sordariales. Most abundant genera included typical endophytes such as Plectosphaerella, Thanatephorus, Podospora, Monosporascus, Exophiala, and Setophoma. A surprising dominance of single taxa was observed for many samples. In summary, 35.23% of reads of the plant endophytic fungal microbiome correlated with changes in the plant metabolome. While the concentration of flavonoid kaempferol glycosides positively correlated with the abundance of many fungal strains, many compounds showed negative correlations with fungi including indolic phytoalexins, a putative glucosinolate but not major glucosinolates and a glutathione isothiocyanate adduct. The latter is likely an in vivo glucosinolate decomposition product important in fungal arrest. Our results show the potency of the untargeted metabolomics approach in deciphering plant–microbe interactions and depicts a complex array of various metabolite classes in shaping the endophytic fungal community.
The Mobile Small RNAs: Important Messengers for Long-Distance Communication in Plants
Authors: Yan Yan , Ham Byung-Kook
Published: June 2022

Various species of small RNAs (sRNAs), notably microRNAs and small interfering RNAs (siRNAs), have been characterized as the major effectors of RNA interference in plants. Growing evidence supports a model in which sRNAs move, intercellularly, systemically, and between cross-species. These non-coding sRNAs can traffic cell-to-cell through plasmodesmata (PD), in a symplasmic manner, as well as from source to sink tissues, via the phloem, to trigger gene silencing in their target cells. Such mobile sRNAs function in non-cell-autonomous communication pathways, to regulate various biological processes, such as plant development, reproduction, and plant defense. In this review, we summarize recent progress supporting the roles of mobile sRNA in plants, and discuss mechanisms of sRNA transport, signal amplification, and the plant’s response, in terms of RNAi activity, within the recipient tissues. We also discuss potential research directions and their likely impact on engineering of crops with traits for achieving food security.
Graduate Students’ Perceived Supervisor Support and Innovative Behavior in Research: The Mediation Effect of Creative Self-Efficacy
Authors: Han Jiying , Liu Nannan , Wang Feifei
Published: June 2022

With increased global competition and the advent of the knowledge economy, developing graduate students’ ability to innovate in their research has become a core focus of graduate education. Graduate students’ perceived help and assistance from supervisors is one of the key resources for research innovation. This study explored the relationships between graduate students’ perceived supervisor support and their innovative behavior in research, and examined the mediation effect of creative self-efficacy, their confidence in abilities to generate creative ideas or produce creative outcomes. Survey data were collected from a sample of 996 Chinese graduate students. The results revealed that academic support was negatively related to idea generation and idea search; personal support was positively related to overcoming obstacles; autonomy support was positively related to all factors of innovative behavior except overcoming obstacles and innovation outputs. The mediation analysis suggested that creative self-efficacy significantly mediated the relationship between academic support and graduate students’ innovative behavior in research. The results of this study highlight the significance of both supervisor support and creative self-efficacy in developing graduate students’ research innovation. The findings have significant implications for stimulating students’ research innovation and for improving the quality of graduate education.
N400 Indexing the Motion Concept Shared by Music and Words
Authors: Zhou Tongquan , Li Yulu , Liu Honglei , Zhou Siruo , Wang Tao
Published: June 2022

The two event-related potentials (ERP) studies investigated how verbs and nouns were processed in different music priming conditions in order to reveal whether the motion concept via embodiment can be stimulated and evoked across categories. Study 1 (Tasks 1 and 2) tested the processing of verbs (action verbs vs. state verbs) primed by two music types, with tempo changes (accelerating music vs. decelerating music) and without tempo changes (fast music vs. slow music) while Study 2 (Tasks 3 and 4) tested the processing of nouns (animate nouns vs. inanimate nouns) in the same priming condition as adopted in Study 1. During the experiments, participants were required to hear a piece of music prior to judging whether an ensuing word (verb or noun) is semantically congruent with the motion concept conveyed by the music. The results show that in the priming condition of music with tempo changes, state verbs and inanimate nouns elicited larger N400 amplitudes than action verbs and animate nouns, respectively in the anterior regions and anterior to central regions, whereas in the priming condition of music without tempo changes, action verbs elicited larger N400 amplitudes than state verbs and the two categories of nouns revealed no N400 difference, unexpectedly. The interactions between music and words were significant only in Tasks 1, 2, and 3. Taken together, the results demonstrate that firstly, music with tempo changes and music without tempo prime verbs and nouns in different fashions; secondly, action verbs and animate nouns are easier to process than state verbs and inanimate nouns when primed by music with tempo changes due to the shared motion concept across categories; thirdly, bodily experience differentiates between music and words in coding (encoding and decoding) fashion but the motion concept conveyed by the two categories can be subtly extracted on the metaphorical basis, as indicated in the N400 component. Our studies reveal that music tempos can prime different word classes, favoring the notion that embodied motion concept exists across domains and adding evidence to the hypothesis that music and language share the neural mechanism of meaning processing.
How Duty-Free Policy Influences Travel Intention: Mediating Role of Perceived Value and Moderating Roles of COVID-19 Severity and Counterfactual Thinking
Authors: Xu Yajun , Ma Wenbin , Xu Xiaobing , Xie Yibo
Published: June 2022

Counterfactual thinking is presumed to play a preparatory function in promoting people’s behavioural intentions. This study specifically addresses the impacts of COVID-19 severity, tourists’ counterfactual thinking about the pandemic, and tourists’ perceived duty-free consumption value on the effect of a duty-free policy on travel intentions. Four hundred and ten participants took part in this study, which involved a 2 (duty-free policy: absent vs. present) × 2 (COVID-19 severity: high vs. low) design. Results reveal the following patterns: (a) compared to the absence of a duty-free policy in tourist destinations, enactment of a duty-free policy leads to stronger visit intentions through greater perceived value and (b) the effect of a duty-free policy on travel intention is moderated by tourists’ counterfactual thinking and COVID-19 severity.
Deep Learning-Based Text Emotion Analysis for Legal Anomie
Authors: She Botong
Published: June 2022

Text emotion analysis is an effective way for analyzing the emotion of the subjects’ anomie behaviors. This paper proposes a text emotion analysis framework (called BCDF) based on word embedding and splicing. Bi-direction Convolutional Word Embedding Classification Framework (BCDF) can express the word vector in the text and embed the part of speech tagging information as a feature of sentence representation. In addition, an emotional parallel learning mechanism is proposed, which uses the temporal information of the parallel structure calculated by Bi-LSTM to update the storage information through the gating mechanism. The convolutional layer can better extract certain components of sentences (such as adjectives, adverbs, nouns, etc.), which play a more significant role in the expression of emotion. To take advantage of convolution, a Convolutional Long Short-Term Memory (ConvLSTM) network is designed to further improve the classification results. Experimental results show that compared with traditional LSTM model, the proposed text emotion analysis model has increased 3.3 and 10.9% F1 score on psychological and news text datasets, respectively. The proposed CBDM model based on Bi-LSTM and ConvLSTM has great value in practical applications of anomie behavior analysis.
Mental Disorders Are Associated With Leukocytes Telomere Shortening Among People Who Inject Drugs
Authors: Durand Mélusine , Nagot Nicolas , Michel Laurent , Le Sao Mai , Duong Huong Thi , Vallo Roselyne , Vizeneux Amélie , Rapoud Delphine , Giang Hoang Thi , Quillet Catherine , Thanh Nham Thi Tuyet , Hai Oanh Khuat Thi , Vinh Vu Hai , Feelemyer Jonathan , Vande Perre Philippe , Minh Khue Pham , Laureillard Didier , Des Jarlais Don , Molès Jean-Pierre
Published: June 2022

Premature biological aging, assessed by shorter telomere length (TL) and mitochondrial DNA (mtDNA) alterations, has been reported among people with major depressive disorders or psychotic disorders. However, these markers have never been assessed together among people who inject drugs (PWIDs), although mental disorders are highly prevalent in this population, which, in addition, is subject to other aggravating exposures. Diagnosis of mental disorders was performed by a psychiatrist using the Mini International Neuropsychiatric Interview test among active PWIDs in Haiphong, Vietnam. mtDNA copy number (MCN), mtDNA deletion, and TL were assessed by quantitative PCR and compared to those without any mental disorder. We next performed a multivariate analysis to identify risk factors associated with being diagnosed with a major depressive episode (MDE) or a psychotic syndrome (PS). In total, 130 and 136 PWIDs with and without psychiatric conditions were analyzed. Among PWIDs with mental disorders, 110 and 74 were diagnosed with MDE and PS, respectively. TL attrition was significantly associated with hepatitis C virus-infected PWIDs with MDE or PS (adjusted odds ratio [OR]: 0.53 [0.36; 0.80] and 0.59 [0.39; 0.88], respectively). TL attrition was even stronger when PWIDs cumulated at least two episodes of major depressive disorders. On the other hand, no difference was observed in mtDNA alterations between groups. The telomeric age difference with drug users without a diagnosis of psychiatric condition was estimated during 4.2–12.8 years according to the number of MDEs, making this group more prone to age-related diseases.
Abnormal Ventral Somatomotor Network Homogeneity in Patients With Temporal Lobe Epilepsy
Authors: Li Dongbin , Liu Ruoshi , Meng Lili , Xiong Pingan , Ren Hongwei , Zhang Liming , Gao Yujun
Published: June 2022

Background

Abnormalities of functional connectivity in the somatomotor network have been thought to play an essential role in the pathophysiology of epilepsy. However, there has been no network homogeneity (NH) study about the ventral somatomotor network (VSN) in patients with temporal lobe epilepsy (TLE). Therefore, we explored the NH of the VSN in TLE patients in this study.

Methods

The sample included 52 patients with left temporal lobe epilepsy, 83 patients with right temporal lobe epilepsy, and 68 healthy controls. The NH method was utilized to analyze the resting-state functional magnetic resonance imaging data.

Results

Compared to the controls, rTLE patients had significantly higher NH in the bilateral postcentral gyrus, and significantly lower NH in the bilateral Rolandic operculum and the right superior temporal gyrus (STG). The NH values of the left postcentral gyrus were significantly higher in lTLE patients than in the healthy controls, and lTLE patients had lower NH in the right Rolandic operculum. The altered NH in the postcentral gyrus was negatively correlated with the illness duration, and the decreased NH in the left Rolandic operculum was negatively correlated with the executive control reaction time (ECRT).

Conclusion

Our findings suggest that altered NH of the postcentral gyrus, Rolandic operculum and STG might be associated with the pathophysiology of TLE, and thus, highlight the contribution of the VSN to the pathophysiology of TLE.
A Resting State Functional Magnetic Resonance Imaging Study of Unmedicated Adolescents With Non-suicidal Self-Injury Behaviors: Evidence From the Amplitude of Low-Frequency Fluctuation and Regional Homogeneity Indicator
Authors: Zhou Yi , Yu Renqiang , Ai Ming , Cao Jun , Li Xiao , Hong Su , Huang Qian , Dai Linqi , Wang LiXia , Zhao Lin , Zhang Qi , Shi Lei , Kuang Li
Published: June 2022

Background

Non-suicidal self-injury (NSSI) behaviors are common in adolescents with major depressive disorder (MDD). Brain studies specifically targeting adolescents with MDD and NSSI may provide new insights into suicide warnings in adolescents with MDD.

Methods

This study examined the whole-brain neural activity in adolescents aged between 12–17 years, 50 unmedicated MDD patients with (nsMDDs) or without NSSI (nnsMDDs), and 25 healthy controls (HCs) participated in this study, and analyzed the correlation between the values of amplitude of low-frequency fluctuation (ALFF), fractional amplitude of low-frequency fluctuation (fALFF) and regional homogeneity (ReHo) in significantly different brain regions and the scores of the relevant clinical psychological scale.

Results

Compared with nnsMDDs, nsMDDs had enhanced ALFF values in left middle occipital gyrus and left median cingulate and paracingulate gyri; the fALFF values of the right caudate nucleus was weakened in the nsMDDs; the ReHo values of right middle occipital gyrus and right middle temporal gyrus weakened and the ReHo values of right medial cingulate gyrus enhanced in nsMDDs. And all of differences were statistically significant. In nsMDDs, the value of ALFF in the left calcarine fissure and surrounding cortex was negatively correlated with the score of Children's depression Inventory (CDI); the value of fALFF in the right caudate nucleus was positively correlated with the score of Beck Scale for Suicidal Ideations (BSSI); the value of ReHo in the right middle temporal gyrus was positively correlated with the score of Multidimensional Anxiety Scale for Children (MASC); and the value of ReHo in the right median cingulate and paracingulate gyri was negatively correlated with the score of BSSI.

Conclusions

We found that in ALFF, fALFF and ReHo, the significant differences between nsMDDs and nnsMDDs are mainly located in default mode network (DMN) and visual network (VN), and there may be brain regions related to NSSI in DMN and VN. The significant differences brain regions in ALFF, fALFF and ReHo between nsMDDs and nnsMDDs were related to the total score of the relevant clinical psychological scale, and may be related to NSSI.
An Evolutionary Model of “Sexual Conflict” Over Women's Age at Marriage: Implications for Child Mortality and Undernutrition
Authors: Wells Jonathan C. K.
Published: June 2022

Background

Early women's marriage is associated with adverse outcomes for mothers and their offspring, including reduced human capital and increased child undernutrition and mortality. Despite preventive efforts, it remains common in many populations and is often favored by cultural norms. A key question is why it remains common, given such penalties. Using an evolutionary perspective, a simple mathematical model was developed to explore women's optimal marriage age under different circumstances, if the sole aim were to maximize maternal or paternal lifetime reproductive fitness (surviving offspring).

Methods

The model was based on several assumptions, supported by empirical evidence, regarding relationships between women's marital age and parental and offspring outcomes. It assumes that later marriage promotes women's autonomy, enhancing control over fertility and childcare, but increases paternity uncertainty. Given these assumptions, optimal marriage ages for maximizing maternal and paternal fitness were calculated. The basic model was then used to simulate environmental changes or public health interventions, including shifts in child mortality, suppression of women's autonomy, or promoting women's contraception or education.

Results

In the basic model, paternal fitness is maximized at lower women's marriage age than is maternal fitness, with the paternal optimum worsening child undernutrition and mortality. A family planning intervention delays marriage age and reduces child mortality and undernutrition, at a cost to paternal but not maternal fitness. Reductions in child mortality favor earlier marriage but increase child undernutrition, whereas ecological shocks that increase child mortality favor later marriage but reduce fitness of both parents. An education intervention favors later marriage and reduces child mortality and undernutrition, but at a cost to paternal fitness. Efforts to suppress maternal autonomy substantially increase fitness of both parents, but only if other members of the household provide compensatory childcare.

Conclusion

Early women's marriage maximizes paternal fitness despite relatively high child mortality and undernutrition, by increasing fertility and reducing paternity uncertainty. This tension between the sexes over the optimal marriage age is sensitive to ecological stresses or interventions. Education interventions seem most likely to improve maternal and child outcomes, but may be resisted by males and their kin as they may reduce paternal fitness.
Does Retirement Make People Happier?-Evidence From China
Authors: Zhang Anqi , Zhang Yi , Tao Yiwen
Published: June 2022

To investigate whether people's happiness will increase after retirement, this paper empirically investigates 2012, 2015, and 2017 China General Social Survey (CGSS) data using Ordinary Least Squares, Binary logit, and Fuzzy regression discontinuity Design. The results all show that retirement will significantly increase the happiness of men in urban China. The paper also validates these findings by testing the continuity of the reference and covariates at the cut–off point, changing the model settings, and using a more rigorous sample classification method. In addition, the article further analyzes the heterogeneity of the study and finds that retirement brings more happiness to those who have a college degree or less and have multiple children. The better the health status, the smaller the effect of retirement on happiness. The more social interactions, the smaller the effect of retirement on happiness. The policy implication of this paper is that when implementing a delayed retirement policy, special care should be taken for groups with greater welfare impairment, and it needs to be introduced together with other supporting measures to reduce people's worries. This paper analyzes the relationship between retirement and happiness in China and makes suggestions for the implementation of a delayed retirement policy, enriching the theoretical and empirical work on the effects of retirement on people's happiness and contributing to the world's response to aging and welfare policies for the older person.
The Relationship Between Built Environment and Mental Health of Older Adults: Mediating Effects of Perceptions of Community Cohesion and Community Safety and the Moderating Effect of Income
Authors: Zhang Rongrong , He Xiong , Liu Ying , Li Ming , Zhou Chunshan
Published: June 2022

Many studies revealed a significant correlation between low-density built environment and the mental health of older adults in developed countries. However, scholars and decision-makers recently began to pay close attention to the effect of this relationship in high-density built environments and in developing countries. Using point-of-interest (POI) data from Baidu and data on 20 communities in Guangzhou, China, which were collected through a questionnaire survey, this study aimed to examine the relationship between built environment and the mental health of older adults as well as the physiological–psychological mediating paths between the two, so as to enrich the research on population aging in the high-density urban context in developing countries. The findings indicated that facility accessibility and distance to parks significantly positively correlated with the mental health of older adults and the number of public transit stations, and the distance to these stations significantly negatively correlated with the mental health of older adults. Also, the perceptions of community cohesion and community safety had a significant mediating effect between the built environment and the mental health of older adults. Furthermore, the moderating effect analysis results verified the moderating effect of income: with an increase in income, the perception of community cohesion enhanced the protection of the mental health of older adults and reduced the mediating effect of the perception of community safety. The results provided a reference for policy-makers and urban planners in their efforts to plan and build health-supporting communities and a healthy aging society.
Health Professionals' Attitude Toward the Use of Social Media for COVID-19 Related Information in Northwest Ethiopia: A Cross-Sectional Study
Authors: Tegegne Masresha Derese , Endehabtu Berhanu Fikadie , Guadie Habtamu Alganeh , Yilma Tesfahun Melese
Published: June 2022

Background

Social media platform is one way to share online information regarding pandemic prevention. However, there is no study regarding the attitude of health professionals toward social media use for the COVID-19-related information. This study aimed to assess health professionals' attitudes toward using social media for COVID-19-related information.

Methods

An institution-based cross-sectional study was conducted among 355 health professionals in Bahir Dar city public health centers, Northwest Ethiopia. A pretested self-administered questionnaire was used to collect the data. The data were entered by EPI-data version 4.6 and analyzed using SPSS version 23 software. Descriptive statistics, bivariable, and multivariable logistic regression analysis were used to describe respondents' attitudes toward using social media for COVID-19 information and identify associated factors. An adjusted odds ratio (OR) and a p-value with a 95% CI were calculated to measure the strength of the association and assess statistical significance.

Result

Out of 341 participants, about 73% of the participants had a good attitude toward the use of social media for COVID-19 information. Age < 24 [adjusted odds ratio (AOR) = 3.74, 95% CI: (1.53–9.13)] and age group 25–34 years [AOR = 2.25, 95% CI: (1.04–4.86)], computer training [AOR = 2.03, 95% CI: (1.03–4.00)], usefulness of social media [AOR = 3.25, 95% CI: (1.58–6.67)], and trustworthiness [AOR = 3.57, 95% CI: (1.93–6.60)] were enabling factors for attitude toward the use of social media for COVID-19 related information.

Conclusion

Health professionals had a moderate attitude toward using social media for accessing COVID-19-related information. This implies that after considering positive attitude predictors, such as providing basic computer training, emphasizing the usefulness of social media, and building trusted social media pages, social media platforms can be used as a source of COVID-19-related information for health professionals.
Exploring the Dynamic Nexus Among Economic Growth, Industrialization, Medical Technology, and Healthcare Expenditure: A PMG-ARDL Panel Data Analysis on Income-Level Classification Along West African Economies
Authors: Tackie Evelyn Agba , Chen Hao , Ahakwa Isaac , Atingabili Samuel
Published: June 2022

This article explored the dynamic nexus among economic growth, industrialization, medical technology, and healthcare expenditure in West Africa while using urbanization and aged population as control variables. West African countries were sub-sectioned into low-income (LI) and lower-middle-income (LMI) countries. Panel data extracted from the World Development Indicators (WDI) from 2000 to 2019 were used for the study. More modern econometric techniques that are vigorous to cross-sectional dependence and slope heterogeneity were employed in the analytical process in order to provide accurate and trustworthy results. The homogeneity test and cross-sectional dependency test confirmed the studied panels to be heterogeneous and cross-sectionally dependent, respectively. Moreover, the CADF and CIPS unit root tests showed that the variables were not integrated in the same order. This, thus, leads to the employment of the PMG-ARDL estimation approach, which unveiled economic growth and urbanization as trivial determinants of healthcare expenditure in the LI and LMI panels. However, the results affirmed industrialization as a major determinant of healthcare expenditure in the LI and LMI panels. Additionally, medical technology was confirmed to decrease healthcare expenditure in the LMI panel, whereas in the LI panel, an insignificant impact was witnessed. Also, the aged population was found to intensify healthcare expenditure in both the LI and LMI panels. Lastly, on the causal connection between the series, the outcome revealed a mixture of causal paths among the variables in all the panels. Policy recommendations have therefore been proposed based on the study's findings.