bluuebunny/crossref_metadata_2025 huggingface dataset:
Open prospective study to evaluate the efficacy of a new vaginal pessary containing 300mg tinidazole, 200mg tioconazole and 100mg lidocaine with a 3-day regime (Gynomax XL®) in the treatment of vaginal infections due to bacterial vaginosis, candidiasis an
Authors: Regidor P.A. , Sailer M.
Published: December 2024

Introduction. The management of infections of the vulva and vagina depend on the selection and administration of effective specific therapies that allow a fast treatment, enhancing the compliance of the patients.
Objective of the study: the efficacy and safety of a new medicinal product containing 300mg tinidazole/200mg tioconazole/100mg lidocaine for the treatment against vaginal candida albicans, bacterial vaginosis and combined infections was evaluated upon 69 patients.
Materials and methods. Clinical controls, pH, 10% KOH probe, microscopical and microbiological analysis were performed at day 1, day 4, day 10 and at day 30 of the study. Success was defined as follows: 0 points = no symptoms, 1 point = mild symptoms, 2 points = moderate symptoms, 3 points = severe symptoms.
Results. A complete clinical recovery at day 10 was observed in 54 (80.6%) patients. A clinical improvement in 12 (17.9%) and a failure in 1 patient (1,5%). At day 30 a clinical complete recovery was observed in 58 (86.6%) patients, a clinical improvement in 7 (10.4%) and a failure in 2 patients (3%).
Conclusions. This formulation (GynomaxXL), a vaginal suppository given at 3 consecutive days, is a highly effective and safe combination in the therapy of vulvovaginal candidiasis and bacterial vaginosis.
Chronic endometritis and endometriosis: what do they have in common?
Authors: Ruda R.A.
Published: December 2024

Background. Chronic endometritis and endometriosis are difficult illnesses to diagnose, due to their non-specific manifestations, but at the same time they are quite common and often result in impaired fertility. Both endometritis and endometriosis are chronic inflammatory diseases that could affect the receptivity of the endometrium, precisely it affects the implantation process, as well as it contributes to early pregnancy losses, which makes a challenge for reproductive specialists. In addition, these diseases negatively affect the social and psychological aspects of a modern woman’s life due to the fact that such common symptoms as pelvic pain, dyspareunia, abnormal uterine bleeding exhaust and deprive the woman at her usual activity and lead to a deterioration of her psycho-emotional state, that requires modern approaches in diagnosis and treatment.Objectives of the study: to identify and investigate the relationship between chronic endometritis and endometriosis.Materials and methods. Endometrial samples taken during pipelle biopsy from 105 women were studied, among them 45 patients without endometriosis and 60 with endometriosis. All women were of reproductive age, had not taken oral contraceptives, progestins, or antibiotics in the past 6 months, and had no neoplastic pathology.A pathohistological examination of the obtained material was performed in all cases. Logistic regression analysis was performed on variables such as age, body mass index, parity, presence of uterine fibroids, and endometriosis.Results. Chronic endometritis was confirmed in 86.7% of patients with endometriosis and in 44.4% of women without signs of endometriosis. Considering these data, it can be argued that chronic endometritis is more common among women with endometriosis compared to women without this pathology. It was also established histologically that the frequency of chronic endometritis in adenomyosis is 2.6 times higher than in other pathologies without endometriosis (52 confirmed cases versus 20).Conclusions. The results of this study indicate a strong connection betISSN 2309-4117ween chronic endometritis and endometriosis.
Fetal inflammatory response syndrome in extremely premature newborns
Authors: Bila V.V.
Published: December 2024

Background. Fetal inflammatory response syndrome (FIRS) is a pathological reaction of the fetal immune system to infection of the amnion or inflammation of the chorion, which significantly increases the risk of neonatal mortality and morbidity.
Objective of the study: to study the clinical features of the course of the neonatal period in premature babies with different gestational periods against the background of FIRS. Material and methods. The course of the neonatal period was analyzed in 405 premature newborns, divided depending on the gestational age and the presence of premature rupture of the fetal membranes. The content of IL-6 in umbilical cord blood was determined in all newborns by enzyme-linked immunosorbent assay. Its value greater than 11 pg/ml was the basis for establishing a diagnosis of FIRS. The duration of respiratory support in general, artificial lung ventilation, non-invasive lung ventilation, and the need for additional oxygen, periventricular hemorrhages, and necrotizing enterocolitis were analyzed in all newborns depending on the presence of FIRS.
Results. Extremely premature newborns with FIRS have a longer duration of both invasive and non-invasive ventilation, newborns from early preterm births with FIRS required non-invasive ventilation longer only in case of premature rupture of the fetal membranes. In extremely premature newborns with FIRS the duration of the additional oxygen supply increases, in newborns from early premature births this pattern was only in the case of premature rupture of the fetal membranes. Only in premature babies from very early premature births with FIRS a doubling of the frequency of hemorrhages in the ventricles of the brain and necrotizing enterocolitis was found.
Conclusions. FIRS in extremely premature newborns is associated with a longer duration of invasive and non-invasive ventilation, as well as with a longer need for oxygen enrichment of inhaled air. FIRS in extremely premature newborns increase the frequency and severity of intraventricular hemorrhages and necrotizing enterocolitis.
Curses as a genre of Lezghi and Kumyk folklore
Authors:   The G. Tsadasa Institute of Language, Literature and Art, Dagestan Federal Research Center of Russian Academy of Sciences, Gasharova Aida R. , Akamov Abusupyan T. ,   The G. Tsadasa Institute of Language, Literature and Art, Dagestan Federal Research Center of Russian Academy of Sciences
Published: December 2024

The article analyzes folk curses that have an emotional charge and relate to abusive language. Most
often they are psychological or domestic in nature. Mostly, this kind of curse is pronounced unconsciously during a domestic quarrel or other conflict. They can be considered as a communicative, imperative and
expletive formula. The purpose of the study is to analyze curses in which the speaker expresses dissatisfaction
and indignation towards the listener. As a rule, they convey the feelings of the speaker or swearer and their
attitude towards a certain situation or a specific person. The object of the study is curses presented in the
folklore of Lezghins and Kumyks. Curses are found in the form of proverbial expressions, prose miniatures,
and individual phrases at the heart of large works (most often in folk songs). We give a general idea of the
functional and semantic aspects of curses. The article proves that curses are detailed figurative statements of
negative content. This genre of folklore has a great practical value. The curses are based on a person’s faith
in the magical component of the word. The article indicates that the distinctive features of curses are semantic
content, emotional richness and color. The authors focus on formulaic curse expressions using the imperative
form of the verb, where the focus is on the intended recipient. The work attempts to present some models
arising from culturally specific characteristics. To simplify the qualitative interpretation of the material, we
divided the texts of curses into various groups based on their relationship to different spheres of life. Thematic
features of verbal formulas are distributed depending on the addressee.
Variability in the manifestation of authorship in academic abstracts: Comparison of humanitarian and natural science discourses
Authors:   Novosibirsk State Pedagogical University, Prasko Maxim V.
Published: December 2024

The article deals with the problem of the intradiscursive variability of the speech genre of the abstract.
The article aims to identify the variability of the manifestation of the author's principle in the verbal genre
of abstract functioning in academic discourse. 38 Russian-language abstracts to linguistic academic articles
published in the journal “Genres of Speech” in 2023 and 34 Russian-language abstracts to biological academic
articles published in the “Journal of General Biology” in 2022 were selected as the base of the study. The
main research methods were general scientific methods (analysis, synthesis, comparison, juxtaposition, content
analysis, statistical analysis), as well as methods of complex linguistic research – lexico-semantic, component,
grammatical, discursive, stylistic, linguistic and pragmatic analyses. It was revealed that the pronouns “we”
and “our” (in 13 % of linguistic and 21 % of biological annotations) and the self-designation “author” (in 11 %
of linguistic and 3 % of biological abstracts) are used in abstracts as explicit markers of the authorʼs presence.
Biologists are more actively using indirect designation through pronouns to emphasize personal contribution
to solving a scientific problem and present results reflecting new knowledge. There are no differences in the
use of implicit authorization tools (passive and impersonal constructions) in the abstracts belonging to the
humanitarian and natural science discourse. To express an evaluative attitude towards the components of an
epistemic situation, qualitative adjectives are used in the abstracts of both scientific directions, but in linguistic
abstracts the set of adjectives is much richer. It was found that in the abstracts of natural science discourse
the strengthening of evaluation using qualitative adverbs is more common (50 %) than in linguistic abstracts
(29 %), as well as the weakening of evaluation – 32 % and 10 %, respectively. This indicates the desire of
the linguistic authors to be more accurate and selective in expressing the strengthening or weakening of the
assessment and, if possible, to avoid such speech strategies. Ii is concluded that the variability of the authorʼs
presence in the verbal genre of abstract, functioning in academic discourse, is due to differences in research
approaches, scientific tradition and the dissimilarity of the worldview of scientists.
The genre of the longread: A sociolinguistic aspect
Authors:   Financial University, Kontsevaya Natalia A.
Published: December 2024

Nowadays some experts call the multimedia longread the heir of the traditional journalistic genres.
The longread successfully combines texts, illustrations, video materials and other elements aimed to attract the
reader and holding their attention. The complicated longread in the Internet media is opposed to the short and
simple shortread which occupies the main place in the information flow of modern people.
The experts are alarming about the declining interest in reading long texts (primarily books) among
young people. That is why it is becoming necessary to study the attitude to longreads among this age group of
Russians. For this purpose, a survey was conducted among 121 students of Russian universities, who measured
the length of the texts they read in the Internet media during one week.
The results of the survey revealed that 67% of the respondents do read longreads during the week. The
survey also revealed two main reasons that prompted the interviewees to read them: significant motivation
(educational process or first job compelled young people to look for answers in texts) and the attractiveness
of articles written so well that reading them was not difficult or boring for this age group. At the same time,
the main reasons for rejection were identified as being related to the quality of the texts themselves (vague
wording, unclear structure), as well as inconvenient formatting (young people prefer to read texts via mobile
devices).
Comparison Effect of Clonidine and Magnesium Sulfate on Bleeding Volume during Septorhinoplasty: A Double-Blind, Randomized Clinical Trial
Authors: Mojaveraghili Seyed Babak , Talebi Fatemeh , Behnampour Nasser
Published: December 2024

Background: Control of hemodynamic changes and blood loss is a daily challenge in general anesthesia for patients undergoing septorhinoplasty. This study aimed to evaluate the effects of magnesium sulfate and clonidine on the control of hemodynamic factors and bleeding volume during this procedure.
Methods: This double-blind, randomized clinical trial study was conducted on 60 patients undergoing septorhinoplasty at 5th Azar Medical & Educational Centre of Gorgan in 2021-2022. Patients were divided into two intervention groups (50 mg/kg of magnesium sulfate) and control group (5 μg/kg of clonidine) with permutation random block allocation. All patients underwent induced hypotension. Before induction of anesthesia and every 5 minutes afterwards, blood pressure was recorded. Blood loss volume was calculated at the end of the surgery.
Results: In the magnesium group, 36 individuals were evaluated, while in the clonidine group, 24 individuals were examined. There were no statistically significant differences in baseline characteristics of patients in the two groups and the duration of surgery. Both drugs were equally effective in inducing hypotension, however blood pressure changes in magnesium group were more trivial than clonidine group. The bleeding volume in the magnesium sulfate and clonidine groups was 139.44 ml and 141.25, respectively and this difference was not statistically significant (p-value=0.634).
Conclusion: The results of this study showed that magnesium sulfate can be effectively used as an alternative to clonidine in controlling hemodynamic changes and ultimately reducing blood loss volume during septorhinoplasty surgery. In addition, magnesium is at least as effective as clonidine in stabilizing hemodynamic changes.
Randomized Controlled Double-Blind Study Comparing Efficacy of Two Doses of Magnesium Sulphate as an Adjuvant to Local Anesthetics in Supraclavicular Block
Authors: Ashraf Suhail , Konnur Shweta , Sancheti Abhay , Mundada Neha , Keniya Varshali
Published: December 2024

Background: Magnesium sulphate (MgSO4) is one of the commonly used adjuvant in regional blocks and proved its analgesic efficacy. However, the exact dose of the drug for perineural administration is still debatable. We compared two different doses of Magnesium Sulphate (150mg and 250mg) as an adjuvant to local anesthetics in ultrasound guided supraclavicular block.
Primary objective was to compare block parameters along with postoperative analgesia duration and secondary objectives were comparison of total analgesic requirement and side effects.
Methods: 90 patients posted for elective upper limb surgeries under supraclavicular block with 12 ml 2% adrenalized lignocaine,12 ml 0.5% bupivacaine were divided in two groups. Group M1 received 150 mg and Group M2 received 250 mg magnesium sulphate.
Results: With addition of 250 mg of Magnesium, the duration of sensory (530.37 ± 67.33 min) as well as motor block (492 ± 80.52 min) was prolonged as compared to sensory (478 ± 72.6 min) and motor (442 ± 83.980 min) block durations with 150 mg. Duration of postoperative analgesia was also prolonged with 250 mg (485.33 ± 79.19 min) as compared to 150 mg (538 ± 67.2 min) respectively. Total number of postoperative analgesic doses were lesser with 250 mg magnesium.
Conclusion: Magnesium sulphate as an adjuvant in supraclavicular block in the dose 250 mg significantly prolonged the duration of sensory as well as motor block, duration of postoperative analgesia with reduction in analgesic requirement postoperatively as compared to the 150 mg with no significant side effects.
Comparison of Low-Dose Naloxone with Ondansetron for Prevention of Sufentanil-Postoperative/Postdischarge Nausea and Vomiting
Authors: Habibabadii Mehran Rezvani , Nazemroaya Behzad , Soltanpoor Mahshad
Published: December 2024

Background: Sufentanil is extensively used as a powerful painkiller for both initiating and sustaining general anesthesia, thanks to its advantages like potent prolonged action, analgesic effect, and hemodynamic stability. Nonetheless, it's important to consider sufentanil's negative side effects, such as postoperative nausea and vomiting (PONV), during the surgical period. Additionally, Naloxone, an antagonist for opioid receptors, is frequently utilized to counteract the lingering effects of opioids after surgery. Hence, we examined the preventative use of low-dose naloxone on PONV and studied its potential mechanism of action.
Methods: After ethical approval and receiving IRCT code, 64 patients were evenly assigned to the naloxone and ondansetron groups prior to surgery. We also monitored the occurrence and intensity of PONV and the use of antiemetic medication within the first 24 hours after surgery. The main focus of our study was to analyze the PONV profile.
Results: The mean age was 49.8±15.5 years, the mean weight 71.8±23 kg, and the mean BMI was 23.5±5.2 kg/m2. No significant difference was detected regarding mean oxygen saturation and arterial pressure between the groups at admission, 15, 30, 60, and 90 min after surgery (p> 0.05). Adverse reactions showed no significant difference during the recovery time between the groups (p> 0.05). The PONV severity and incidence are significantly higher in the naloxone group.
Conclusion: Naloxone can be used as an antiemetic medicine, besides the ondansetron, and using this agent individually cannot prevent nausea and vomiting effectively.
Clinical Outcomes of Using Dexmedetomidine, ProDex and Popfol for Sedation during Mechanical Ventilation in Patients Hospitalized in the Intensive Care Unit: A Triple Blinded Clinical Trial
Authors: Heidari Saied Morteza , Habibzadeh Mohammadreza , Honarmand Azim , Nazemroaya Behzad , Mousavi Sayed Abolfazl
Published: December 2024

Background: Sedation plays a crucial role in the care of intensive care unit (ICU) patients, addressing the challenges presented by factors such as agitation, anxiety, and delirium, particularly during mechanical ventilation (MV). Dexmedetomidine and propofol are commonly used sedatives, each with its unique characteristics and side effects. Combining these agents has been proposed to optimize effectiveness and minimize adverse effects. This study aims to compare the efficacy of the dexmedetomidine-propofol combination with dexmedetomidine alone and propofol alone for sedation during mechanical ventilation in ICU patients.
Methods: A triple-blinded clinical trial was conducted in Isfahan, Iran, involving patients eligible for spinal fusion surgery and mechanical ventilation. Patients were randomized into three groups: dexmedetomidine alone (DO), propofol alone (PO), and a combination of both drugs (DP) dexmedetomidine-propofol (ProDex). Various dosages and infusion protocols were carefully administered, and patients were assessed for demographic and clinical variables. Hemodynamic parameters and sedation levels were monitored, and statistical analysis was performed.
Results: The study involved 87 patients, with the ProDex group demonstrating the shortest mechanical ventilation duration. Hemodynamic stability was observed in the ProDex group, with significantly lower systolic blood pressure and heart rate compared to other groups. Sedation scores did not differ significantly among groups, suggesting similar sedative effects. The ProDex group exhibited favorable outcomes despite differences in hemodynamic variables.
Conclusion: The dexmedetomidine-propofol combination appears effective in minimizing side effects associated with monotherapy sedation, leading to favorable clinical outcomes. This study contributes valuable insights into optimizing sedation strategies for mechanically ventilated ICU patients.
Persian version of the University of Washington Quality of Life Questionnaire (UW-QOL): Reliability and Validity Study
Authors: Pouresmaeil Ali , Sohrabpour Saeed , Aghaei Behnaz , Erfanian Reza , Noury Leyla , Asadi Kiapey Amirmohsen , Shoormeij Anahit , Abdolahi Mina , Yousefi Abolghasem
Published: December 2024

Background: The University of Washington quality of life questionnaire (UW-QOL) is widely used to evaluate the quality of life for head and neck cancer patients. The purpose of this study is translation of the UW-QOL questionnaire's into Persian.
Methods: After translation and cultural adaptation of the UW-QOL, the questionnaire was distributed among 100 head and neck cancer patients. Internal reliability of the translated UW-QOL was determined using Cronbach's alpha coefficient. The validity was determined by Spearman correlation coefficient between UW-QOL and 12-Item Short Form Survey (SF-12). The test – retest reliability was measured by Intraclass Correlation Coefficient (ICC) after one week.
Results: Cronbach's alpha coefficient was more than 0.75 and ICC coefficient was more than 0.80 in all variables. The UW-QOL questionnaire composite score had a positive significant association with SF-12 questionnaire total score (Spearman's Correlation Coefficient= 0.70, P< 0.0001).
Conclusion: In conclusion Persian translation of the UW-QOL questionnaire has acceptable reliability and validity and is as valid as the original English version in evaluating the quality of life for patients with head and neck cancer.
Improving Safety and Reducing Clinical Errors in Anesthesia: Which Checklist Is Your Choice?
Authors: Babajani Alireza , Sajadi Atiyeh Sadat , Beiranvand Zahra Pirdadeh , Taghizadeh Shaghayegh , Moradimajd Parisa
Published: December 2024

The safety of the beating heart is a health service that means the absence of clinical errors during the implementation of health care. The period of anesthesia is identified as one of the most critical phases for patients requiring general anesthesia, carrying the potential for critical clinical errors that may have irreversible consequences. This study's main objective was to conduct a concise assessment of the anesthesia checklists utilized to enhance patient safety during general anesthesia procedures. To accomplish this, a comprehensive search was conducted using relevant keywords spanning from 1990 to 2023 across databases including PubMed, Springer, Google Scholar, Web of Science, Scopus, online libraries, and the Cochrane library. Initially, 188 studies were identified at the outset of the research, and among these, 13 studies that focused on the development of checklists for anesthesia safety were scrutinized. Included articles were reviewed separately and divided into 3 categories; Specific vs. Generalized Scope, Single-Stage vs. Multi-Stage, Single-Factor vs. Multi-Factor. According to the findings from these studies, the systematic and proper utilization of all available checklists can contribute to improved safety. However, due to the specialization of surgical procedures and the increasing emphasis on patient safety over the past decade, there has been a shift in the compilation of anesthesia checklists from being broad and general to becoming specific, transitioning from single-stage to multi-stage, and evolving from single-factor to multi-factor checklists.
Traumatic Tension Pneumothorax with Extensive Subcutaneous Emphysema
Authors: Rastegari Hojat , Heidari Mehdi , Keykha Aliakbar
Published: December 2024

Tension pneumothorax (TPT) in trauma patients is an uncommon disorder caused by the progressive accumulation of air in the pleural cavity. In pre-hospital and emergencies, if it is not diagnosed and treated on time, it endangers the lives of patients. In this study, we report a patient who developed tension pneumothorax and extensive subcutaneous emphysema due to mild trauma and not going to the hospital in the early hours, which caused an anaphylactic appearance on the patient's face.
"Shoulder Anterior Capsular Block: An Effective Strategy for Alleviating Pain During Shoulder Mobilisation in Adhesive Capsulitis Patients": A Case Series
Authors: Sundaresan Saravanakumar , Vaidiyanathan Bhavani , Raajesh I.Joseph
Published: December 2024

Frozen shoulder is a condition of varying severity characterized by the gradual development of global limitation of active and passive shoulder motion where radiographic findings are limited and associated with severe shoulder pain. Frozen shoulder is also referred to as adhesive capsulitis, painful stiff shoulder, and periarthritis. Treatment typically focuses on reducing shoulder pain and restoring joint mobilisation.
In the context of shoulder mobilization, the predominant nerve blocks encompass the interscalene, supraclavicular upper trunk block collectively referred to as the SCUT block, as well as the axillary nerve block. These nerve blocks demonstrate high efficacy in delivering targeted analgesia. However, a notable limitation of these interventions is the concomitant motor blockade and phrenic nerve block induced by them. This motor blockade poses a significant impediment to the initiation of early rehabilitation, thereby delaying the commencement of rehabilitative exercises and intervention.
Shoulder Anterior Capsular Block is a motor sparing block which can be effectively used in shoulder mobilisation.
Klasik Şiirin 20.Yüzyıldaki Temsilcilerinden Sofuzâde’nin Poetik Gazellerinde Şiire ve Şairliğe Dair Görüşleri
Authors: Yılmaz Dilek
Published: December 2024

Kastamonulu şair ve yazar Sofuzâde Mehmet Tevfik Efendi (1874-1960) edebî anlayışını, şiire ve şairliğe dair görüşlerini farklı yönleri ile ortaya koyan şiirler kaleme almıştır. Sofuzâde’nin gazel formunda kaleme alınmış, manzum poetika niteliğindeki bu şiirlerinde, şiirin özelliklerini, şairin vasıflarını ve dini-tasavvufi söylemin temellerini ortaya koyabilme gerekçesi ile bu makale kaleme alınmıştır. Bahsi geçen poetik şiirler müstakil bir biçimde, daha evvel akademik bir çalışmaya konu olmamıştır. 20. yüzyılda klasik şiir geleneği içinde, özellikle dini-tasavvufi ve hikemi tarzın bir temsilcisi olarak Sofuzâde’de varolan fikri ve edebî devamlılığın ya da kırılmanın tezahürlerinin görülebilmesine yönelik gaye konunun seçilmesindeki kuvvetli saiklerdendir. Onun bahsi geçen şiirlerinden bazıları “şiirimin, şairin, sözüm ve sühan” gibi doğrudan şiiri çağrıştıran ya da “öğrensin” gibi şairliği ilan ve ispata yönelik kelimelerle müreddeftir. Bazıları ise farklı rediflerle bezenmiş olsa da mana ve kavramlar itibariyle hep şiirin etrafında dolanır. Sofuzâde’nin şair ile ilgili tanımlamalarına kimi zaman “gerçek şair”i genel manada tasvir ettiği kimi zaman da şair geçinenler/müteşairler ve bunların özelliklerine değindiği beyitlerde rastlanır. Yer yer kendi şiirini ve şairliğini de öven Sofuzâde, böylelikle şair kimdir sorusuna ayrıntılı cevaplar sunar. Sözün ve nazmın nasıl olması gerektiğine, şiirin sadece duygunun değil aynı zamanda şuurun da bir göstergesi olduğuna vurgu yapar. Ona göre şiir, endişenin (düşünce) lafza dökülmüş halidir, zekânın nişanıdır ve şuurun neticesidir. Sofuzâde sadece beş duyu ile sınırlanmış bir şuurdan bahsetmez. Şuurun ruh ve kalple irtibatına vurgu yapar ayrıca sezgiye dayalı irfanî söyleme atıfta bulunur. Onun şiirlerinin başlıca kaynağı Kur’an-ı Kerim’dir. Fatiha suresinden feyiz aldığını dile getiren şairin gayesi hakikati duyurmaktır. Bu bağlamda şiirlerini cihat ehlinin keskin kılıcına benzetir. Cenâb-ı Hakk’ın yardımı ve kalbine doğan sünuhat ile yazdığı şiirleri, bazen düşünce dünyasında anlamın ruhu olur; bazen mazlumların sesini duyurmak için tarihi birer vesika halini alır. Sûfî çehreli bir şair olarak Sofuzâde, “küntü kenzen” rivayeti ile irtibatlı bir biçimde “aşkı” şairlik için en önemli unsur olarak kabul eder çünkü aşk-ı hakikîyi bilen kişi hayatın manasını anlayacaktır. Hayat aslında “hüsn ve aşk”ın farklı hallerinin görünümleridir. Aşk bilgiyi, sezgiyi, irfanı ve marifeti arttırır. Bu nedenle aşktan nasibi olmayan şairlerin taklitten tahkîke ulaşamamış, lafızdan öze inememiş, kafiyenin büyüsü ile söylenmiş şiirlerini eleştirir. Varoluşu şiire, aşkı da bu şiirin mazmununa benzetmesi onun şiirle ilgili düşüncelerinin tasavvufi eksende nasıl şekillendiğine dair dikkat çekici bir unsur olarak belirginleşir.
YABANCI SEYYAHLAR GÖZÜNDEN İSTANBUL YANGINLARI İLE MÜCADELE: TULUMBACI TEŞKİLATI VE TULUMBACILARA DAİR GÖZLEMLER
Authors: Menekşe Metin
Published: December 2024

Farklı nedenlerle Osmanlı coğrafyasını ziyaret edenler, seyahatleri esnasında Osmanlı dünyasını ve insanlarını tanımışlar, edindikleri bilgileri, deneyimlerini ülkeleriyle paylaşmışlardır. Bu bilgiler, seyyah hayatta iken veya ölümünden sonra “seyahatname” adı altında kitaplaştırılmıştır. Bu eserler, tarih araştırmalarında birincil derecede olmasa da ötekinin dışarıdan nasıl görüldüğünün anlaşılması bakımından dikkate alınması gereken kaynaklar arasında yer almaktadır.
Yabancı seyyahlar, Osmanlı coğrafyasında bulundukları zaman diliminde etkili olan doğal afetlere de çoğunlukla dikkat çekmişlerdir. Nitekim bunlardan biri olan yangınlar, bir tehdit unsuru olarak yüzyıllarca devleti ve halkı oldukça meşgul etmiştir. Zira birçok seyyah da eserlerinin İstanbul’la ilgili bölümünde yangınlara özel bir başlık açmış, bu hususu çeşitli yönleriyle işlemiştir. İstanbul merkezinde çok sık ortaya çıkan yangınların nedenlerine, tahribatına, ortaya çıkan zarara yer vermişlerdir. Şehirde oldukça etkili olan bu yangınlar karşısında Osmanlı yetkililerinin veya halkının yaklaşımına değinmişledir. Ayrıca yangın söndürme konusunda teşkilatlanmaya giden devletin, bu anlamda oluşturduğu tulumba teşkilatının ve görevlilerinin nasıl bir işlev gördüğünü, zayıf veya güçlü yönlerini, birtakım aksaklıkları işlemişlerdir. Netice itibariyle bu çalışmada, İstanbul’u ziyaret eden yabancı seyyahların gözlemlerinden hareketle, İstanbul’un farklı semtlerinde çıkan yangınlara dikkat çekmek, özellikle de tulumbacı teşkilatının işleyişi ve tulumbacı birliklerinin faaliyetlerine yer vermek amaçlanmıştır.
Hilbert Algebras with Hilbert-Galois Connections II
Authors: Celani Sergio A. , Montagie Daniela
Published: December 2024

Hilbert algebra with a Hilbert-Galois connection, or HilGC-algebra, is a triple \(\left(A,f,g\right)\) where \(A\) is a Hilbert algebra, and \(f\) and \(g\) are unary maps on \(A\) such that \(f(a)\leq b\) iff \(a\leq g(b)\), and \(g(a\rightarrow b)\leq g(a)\rightarrow g(b)\) forall \(a,b\in A\). In this paper, we are going to prove that some varieties of HilGC-algebras are characterized by first-order conditions defined in the dual space and that these varieties are canonical. Additionally, we will also study and characterize the congruences of an HilGC-algebra through specific closed subsets of the dual space. This characterization will be applied to determine the simple algebras and subdirectly irreducible HilGC-algebras.
Phylogrouping, Virulence Profile and Antibiogram of Escherichia coli Strains Associated with Canine Pyometra
Authors: Archana T.S. , Sankar Surya , Mani Binu K. , Harshan Hiron M. , Vidya P. , Anand Amrutha , Abraham Bincy K.
Published: December 2024

Background: Multi-drug resistant bacterial strains with biofilm-forming ability are one of the significant reasons contributing to the failure of medical management and recurrence of canine pyometra. The predominant bacterial agent implicated in canine pyometra is Escherichia coli, the different strains of which can be grouped into distinct phylogroups with the same ecological niches, characteristics and tendency to cause disease. The identification of a phylogroup of an unknown strain can facilitate the control, prevention and treatment of infections. Methods: The isolates of E.coli obtained from 25 clinical cases of pyometra were identified based on the cultural, morphological and biochemical characteristics. The antibiogram of the isolates were done employing Kirby-Bauer disk diffusion method. Biofilm forming ability of theisolates were detected by tissue culture plate method and the presence of virulence genes among them were detected using a multiplex PCR. The phylogrouping of E. coli was done employing the novel quadruplex PCR method. Result: In the antibiogram, most isolates were found sensitive to Amoxycillin-clavulanate (90%), Gentamicin (80%),Tetracycline (50%) and Amikacin (50%), while 100% resistance were shown towards ceftazidime-clavulanate, enrofloxacin,ceftriaxone-tazobactam, ciprofloxacin and cefotaxime-clavulanate. Among the E. coli isolates, strong and moderate biofilm producers showed resistance to a wide range of antibiotics compared to non-biofilm producers. Around 80% of the isolates belonged to the phylogroup B2 and all of these had the presence of fimH, sfa, and csgA genes. Among the isolates belonged to the phylogroup B2, 87.5% of the isolates had pap gene while none of them possessed afa gene.
Ulnar Bone Grafting for the Repair of Radial Fracture in a Dog with Degloving Injury
Authors: Lee Shin-Ho , Seo Jeonghyun , Cho Jae-Hyeon
Published: December 2024

Background: A one-year-old female Poodle weighing 1.7 kg sustained an open wound and radial bone fracture due to a bicycle accident. The injury resulted in significant skin and bone loss. Skin reconstruction using an advancement flap and radial bone repair using an autologous ulnar bone graft were performed to restore limb function and appearance. Methods: The dog underwent surgery for skin and bone reconstruction. Necrotic tissue was debrided and an advancement flap was used to repair the skin. The radial bone defect was treated with an autologous ulnar graft and stabilized with a titanium plate. Postoperative care included pain management, antibiotics and restricted activity. Periodic radiographs were taken to monitor bone healing. Result: The dog experienced good recovery, with the skin healing fully within 15 days despite some initial necrosis. The ulnar bone graft successfully fused with the radial bone, allowing the dog to bear weight on the limb by day 65. By day 233, the bone had fully integrated and the dog showed no signs of lameness.
Tibialis anterior tendon transferi tespitinde çapa dikiş, askı düğme sistemi ve tünel yöntemlerinin karşılaştırmalı biyomekanik ve anatomik analizi
Authors: Vahabi Arman , Pekedis Mahmut , Dastan Ali Engin , Yağmuroğlu Kadir , Yıldız Onur , Bilge Okan , Kaya Hüseyin , Günay Hüseyin
Published: December 2024

Amaç: Tendon transferleri, ortopedik cerrahide özellikle pediatrik deformiteler ve sinir hasarı sonrası fonksiyonel kapasiteyi arttırmak amacıyla sık kullanılan tekniklerdir. Tendon transferleri birkaç temel prensip etrafında şekillenmiştir. Bu prensipler transfer sonrası hareket beklenen eklemin esnek olması, transfer yapılacak yumuşak dokunun iyileşmeye elverişli olması, donor tendonun yeterli ekskürsiyona ve kuvvete sahip olması, doğrusal bir çekiş eksenine sahip olması ve aynı zamanda feda edilebilir olmasıdır. Bu prensiplerin çoğu iyi bir preoperatif planlama ile uyulabilecek sınırları ifade ederken intraoperatif değiştirilebilir temel değişken olarak transfer edilecek bölgedeki dokunun mahiyeti ve uygulanacak transfer tekniğinin bu doku ile etkileşimi olarak öne çıkmaktadır.
Gereç ve Yöntem: Çalışmamızda osseotendinöz bir iyileşme beklentisi ile tarsal kemiklere transfer edilerek tespit edilen tibialis anterior transferi uygulamalarında 3 farklı tespit yöntemini kıyaslamayı amaçladık. Bu teknikler: 1) Askı düğme sistemi ile tespit 2) Çapa dikiş ile tespit 3) Tünel tekniği ile tespit. Bunun için toplam 9 kadavrada 3 farklı cerrahi teknik 3er farklı kadavrada uygulanmıştır. Sonuç parametresi olarak tespit sonrası transfer edilen tendonun traksiyon kuvveti ile direnebildiği maksimum kuvvet, maksimum kuvvet etki ettiği andaki deplasman değerlendirilmiştir. Biyomekanik testin tamamlanmasının ardından tibialis anterior transfer edilen ayak bileği mediali disseke edilerek median plantar sinirin hasarlanıp hasarlanmadığı araştırılmıştır.
Bulgular: Deneylerde elde edilen sonuçlara göre gruplar arasında kopma öncesi maksimum kuvvet değerinde ve maksimum kuvvet uygulandığı andaki deplasman miktarında anlamı bir fark olmadığı ortaya konulmuştur. Dokuz kadavranın hiçbirinde median plantar sinir hasar görmemiştir.
Sonuç: Önerilen tekniğin karşılaştırılan teknikler ile benzer biyomekanik dayanım sunması, implant maliyeti olmaması, kalıcı tespit materyali bırakılmasını gerektirmemesi ve nörovasküler hasar yaratma olasılığı açısından risk oluşturmaması sebebiyle etkin ve güvenli bir yöntemdir.
Evaluating biomarkers for diagnosis and treatment monitoring in gaucher disease
Authors: Yazıcı Havva , Erdem Karapınar Fehime , Yoldaş Çelik Merve , Canbay Erhan , Canda Ebru , Demirel Sezer Ebru , Kalkan Uçar Sema , Y. Sözmen Eser , Çoker Mahmut
Published: December 2024

Aim/Objective: The primary goal of this study is to explore the impact of consistent treatment on key disease marker, Lyso-Gb1. Additionally, this research aims to evaluate the influence of splenectomy on Lyso-gb1 concentrations within the patient group.
Materials and Methods: 37 patients diagnosed with GD were categorized based on treatment compliance into three groups: 28 in the regular treatment group, who consistently followed their treatment; 6 in the irregular treatment group, with inconsistent treatment adherence; and 3 in the untreated group. A control group of 33 healthy individuals without GD was also included. Enzyme replacement therapy was utilized as the treatment regimen. The analysis of Lyso-Gb1 levels was performed using liquid chromatography coupled with tandem mass spectrometry, ensuring high precision in measurement.
Results: Lyso-Gb1 levels were significantly higher in GD patients compared to the healthy control group (p<0.05), affirming its potential as a specific biomarker. Treatment was associated with a reduction in Lyso-Gb1 levels (p<0.05). No significant difference in Lyso-Gb1 levels was observed between treated patients with Type 1 and Type 3 GD (p>0.05). Notably, patients who underwent splenectomy exhibited significantly higher Lyso-Gb1 levels than those who did not (p<0.05).
Conclusion: Our findings support the utility of Lyso-Gb1 as a specific biomarker for GD. While pre-treatment Lyso-Gb1 levels in the treated group remain unknown, our results underscore the need for larger, longitudinal studies to further elucidate Lyso-Gb1's role in monitoring disease progression and treatment efficacy in GD.
Effect of preoperative C-reactive protein/albumin ratio on postoperative survial in gastric adenocarcinomas
Authors: İsmayilzade Kenan , Güler Erkan , Ersin Muhtar Sinan , Fırat Özgür , Göktepe Berk , Sezer Taylan Özgür
Published: December 2024

Background and Aim: Since the survival time is still low in end-stage gastric cancers, additional treatment and prognostic factors are being investigated. This study aimed to evaluate significance of preoperatively measured C-reactive protein (CRP)/ Albumin ratio in gastric adenocarcinomas and effect on postoperative survival.
Patients and Methods: A total of 258 patients underwent elective gastric adenocarcinoma surgery were investigated retrospectively. Disease-free, overall survival were evaluated according to the last CT, MRI and PET/CT scans performed during their follow-up. Demographic data, operation reports, pathology reports and imaging results of thepatients were collected. The preoperative values of CRP and albumin were recorded and CRP/ Albumin ratio was calculated . After exclusion criteria, a total of 208 patients were included in the study.
Results: There was a significant relationship between the preoperatively measured CRP/Albumin ratio and postoperative survival time. The predictive power of the CRP/Albumin ratio on the exitus was 4.7%. The predictive power of CRP/Albumin ratio on the exitus increased up to 42.5% together with the other parameters affecting survival.
Conclusion: High CRP/Albumin ratio measured preoperatively was associated with the low survival in the postoperative period in the patients with gastric adenocarcinomas who underwent curative surgery. Considering the fact that elevation of CRP may not be kept down due to the tumoral tissue, fixing albumin level by the healing of nutritional status of the patients in the preoperative period is the most important way to manage this rate.
Size-dependent toxicological effects comparison of Aluminum Oxide Nanoparticles (Al2O3 NPs)
Authors: Bakan Buket
Published: December 2024

Modification of nanomaterials with different synthesis methods can affect their biological response, as well as their use as nanotherapeutics. It is necessary to address and understand the safety issue of these particles through toxicological evaluation with an underlying mechanism of interaction. With the fast entry of aluminum-based nanoparticles into the industry, their potential exposure has also increased significantly. Aluminum oxide nanoparticles (Al2O3 NPs) are among the priority materials by international organizations. Studies have not yet elucidated the toxic response of Al2O3 NPs depending on their size range.
Therefore, this study aimed to investigate toxicological effects of Al2O3 NPs depending on size range on MCF-10 and MCF-7 cells by WST-1 test, hemolytic activity on red blood cells and irritation effects by HET-CAM test. As a result of tests, all size ranges of Al2O3 NPs didn’t show any cytotoxic effects on MCF-10 and MCF-7 cells, also none of sizes of Al2O3 NPs were caused hemolysis (
Nonclinical safety assessment of vaccines: Up to date applications
Authors: Karabay Ülkü
Published: December 2024

Vaccines have a great impact on global health. These pharmaceutical products are prophylactic agents administered to healthy individuals, involving infants and children. Therefore, it is important to demonstrate the safety of them with nonclinical studies before the start of clinical trials. Nonclinical assessment includes product characterization, both in vitro and in vivo testing of vaccines, adjuvanted vaccines or vaccine adjuvants. In vivo safety studies contain pharmacology studies, pharmacokinetic studies, general toxicity studies, developmental and reproductive toxicity, genotoxicity and carcinogenicity studies, and immunogenicity assessment. These tests should be conducted in compliance with GLPs. Nonclinical studies are conducted to determine the safety and appropriate dose to induce an immune response in animal models. A benefit-to-risk profile is considered for each vaccine because of many factors that affect nonclinical and clinical toxicities. Herewith, the non-clinical safety evaluation of vaccines, including toxicity testing, has been focused. Nonclinical testing requirements are an essential tool to determination of the safety and efficacy of vaccines.
Síndrome cardiorrenal tipo 1: prevalência e fatores associados
Authors: Fábia Rayra da Silva Bispo dos  , Santos Jefferson Pereira dos , Da Silva Teixeira Jessica , Rodrigues Karla Neco , Lemos Lucas Brasileiro , Lemos Gisele da Silveira
Published: December 2024

Objetivo: Avaliar a síndrome cardiorrenal tipo 1: prevalência e fatores associados. Métodos: Estudo transversal em pacientes com insuficiência cardíaca aguda, ≥ 18 anos e tempo de internamento ≥ 48 horas. A associação entre variáveis dependentes e independentes foi realizada por análise bruta e ajustada, utilizando modelo de regressão logística binária. Resultados: Foram avaliados 226 pacientes, 53,6% sexo masculino e 75,0% ≥ 60 anos. Verificou-se prevalência de 12,4% de injúria renal aguda (IRA), sendo a mortalidade em pacientes com IRA de 35,7% e sem IRA de 9,1%. Houve associação estatística entre IRA e contraste (RP =398,32; IC = 7,56-20995,44), vasodilatadores endovenosos (RP = 21,79; IC = 2,73-173,63), escore de risco admissional (RP = 23,03; IC = 1,61-329,06) e não interconsulta com nefrologista (RP = 16,97; IC = 3,86-74,58). Conclusão: A IRA foi prevalente em pacientes com insuficiência cardíaca aguda (ICA), com maior tempo de internamento e mortalidade. Alguns fatores preditivos ao desenvolvimento de IRA, ainda não abordados pela literatura, foram não interconsulta com nefrologista, escore de risco admissional e vasodilatadores endovenosos.
"Uma fé sem obras é uma fé morta"
Authors: Reis Lívia
Published: December 2024

Este artigo tem como objetivo desvelar os regimes de engajamento de jovens membros à Igreja Universal do Reino de Deus (IURD) em Maputo, sul de Moçambique. Tendo como base dados de campo coletados entre 2014 e 2015, foi possível identificar um conjunto de práticas e técnicas que visavam promover a integração entre o corpo do crente e o Espírito Santo, e, ao mesmo tempo, a expansão da igreja pela cidade. Essa busca pela “comunhão com Deus”, vale dizer, fornecia aos membros ferramentas para reinterpretar os percalços da vida e a busca por prosperidade a partir do pertencimento religioso, mas exigia, em contrapartida, que eles se dispusessem a transformar sua “fé em obras”, intervindo na realidade ao redor. À luz do conceito de performance, demonstro que esse conjunto de atividades era realizado por um tipo-ideal de membro, o membro-engajado, comprometido com três atividades fundamentais: ir à igreja, buscar a Deus e assumir um compromisso. Argumento, ao final, que a performatividade crente está intrinsecamente ligada à uma forma de intervenção no mundo que articula corpo e espírito, práticas individuais e coletivas, religiosas e políticas em um projeto de mudança que visa transformar a si mesmos, mas também contribui para uma maior presença pública do pentecostalismo brasileiro em Moçambique.
Atividade de campo de Geologia
Authors: Mescolotti Patricia Colombo
Published: December 2024

Introdução. A atividade de campo é um instrumento essencial para o ensino-aprendizado das Geociências. No entanto, muitas vezes essa abordagem didática não é adotada, principalmente por questões financeiras, burocráticas e logísticas. A pandemia de Covid-19 evidenciou ainda mais o quanto este tipo de atividade pode ser prejudicado. Objetivo. Buscando viabilizar uma atividade de campo durante a pandemia, para que o aluno usasse e aprofundasse, na prática, os conhecimentos ministrados na disciplina de Geologia, foi proposta uma atividade de campo virtual. Metodologia. Foram propostos três roteiros distintos em bacias sedimentares brasileiras. Resultados. Os alunos “percorreram” com o Street View do Google Earth ou Google Maps o roteiro escolhido pelo grupo. Cada grupo selecionou seis pontos do roteiro com exposições rochosas e, em cada ponto, descreveram, ilustraram e interpretaram o afloramento. Os alunos elaboraram relatórios de campo, com mapas, figuras e esquemas. Conclusão. A aplicação da atividade de campo virtual mostrou-se uma boa ferramenta para complementar o ensino de Geologia, com a participação ativa dos alunos, e com bons resultados. Contudo, apesar de ser interessante, o campo virtual não substitui a atividade de campo de forma presencial.