bluuebunny/crossref_metadata_2025 huggingface dataset:
Digitalizing and Upgrading Severe Acute Respiratory Infections Surveillance in Malta: System Development
Authors: Cauchi John Paul , Borg Maria-Louise , Džiugytė Aušra , Attard Jessica , Melillo Tanya , Zahra Graziella , Barbara Christopher , Spiteri Michael , Drago Allan , Zammit Luke , Debono Joseph , Souness Jorgen , Agius Steve , Young Sharon , Dimech Alan , Chetcuti Ian , Camenzuli Mark , Borg Ivan , Calleja Neville , Tabone Lorraine , Gauci Charmaine , Vassallo Pauline , Baruch Joaquin
Published: September 2022

Background

In late 2020, the European Centre for Disease Prevention and Control and Epiconcept started implementing a surveillance system for severe acute respiratory infections (SARI) across Europe.

Objective

We sought to describe the process of digitizing and upgrading SARI surveillance in Malta, an island country with a centralized health system, during the COVID-19 pandemic from February to November 2021. We described the characteristics of people included in the surveillance system and compared different SARI case definitions, including their advantages and disadvantages. This study also discusses the process, output, and future for SARI and other public health surveillance opportunities.

Methods

Malta has one main public hospital where, on admission, patient data are entered into electronic records as free text. Symptoms and comorbidities are manually extracted from these records, whereas other data are collected from registers. Collected data are formatted to produce weekly and monthly reports to inform public health actions. From October 2020 to February 2021, we established an analogue incidence-based system for SARI surveillance. From February 2021 onward, we mapped key stakeholders and digitized most surveillance processes.

Results

By November 30, 2021, 903 SARI cases were reported, with 380 (42.1%) positive for SARS-CoV-2. Of all SARI hospitalizations, 69 (7.6%) were admitted to the intensive care unit, 769 (85.2%) were discharged, 27 (3%) are still being treated, and 107 (11.8%) died. Among the 107 patients who died, 96 (89.7%) had more than one underlying condition, the most common of which were hypertension (n=57, 53.3%) and chronic heart disease (n=49, 45.8%).

Conclusions

The implementation of enhanced SARI surveillance in Malta was completed by the end of May 2021, allowing the monitoring of SARI incidence and patient characteristics. A future shift to register-based surveillance should improve SARI detection through automated processes.
ZAPADNO NERAZUMEVANJE RUSKO-SRPSKOG PRAVOSLAVNOG ISTOKA
Authors: Simic Savo
Published: September 2022

Prikaz:
Slobodan Antonić 2022. Dva zavetna naroda: Rusi i Srbi. Beograd: Katena Mundi, 77 str.
BERLINOVO SHVATANJE ODNOSA IZMEĐU VREDNOSNOG PLURALIZMA I MORALNOG I KULTURNOG RELATIVIZMA
Authors: Stancic Visnja , Stojadinovic Misa
Published: September 2022

Predmet ovog rada jeste temeljno razmatranje vrednosnog pluralizma i moralnog i kulturnog relativizma, kao različitih meta-etičkih teorija. U fokusu analize nalazi se Berlinovo shvatanje vrednosnog pluralizma, odnosno distinkcija između vrednosnog monizma i pluralizma, kao i implikacije ovakvog razlikovanja. Autori najpre obrazlažu relevantnost ove teme u okviru moralnih i političkih rasprava, ističući povezanost ovog problema sa drugim ključnim pitanjima, kao što su pojmovi slobode, ljudske prirode i uloge razuma. U prvom delu rada autori će predstaviti Berlinovo stanovište vrednosnog pluralizma, kao shvatanja po kome, suprotno monizmu, suštinu vrednosti čini njihova potencijalna međusobna inkompatibilnost i nesamerljivost, odnosno odsustvo apsolutne vrednosti. U drugom delu rada autori će prikazati i analizirati relevantne kritike Berlinovog shvatanja vrednosnog pluralizma od strane savremenih teoretičara, sa fokusom na Grejevo tumačenje. Ove kritike se svode na interpretaciju Berlinovog shvatanja kao radikalnog pluralizma, subjektivizma i moralnog i kulturnog relativizma. Primarni cilj ovog rada jeste da pokažemo po čemu se Berlinova pozicija razlikuje od ovakvih stanovišta i zašto se ne može svesti na njih. U svetlu gore pomenutih razmatranja, zaključak autora je da shvatanje o postojanju minimalnog jezgra univerzalne ljudske prirode i moralnosti jeste ono što razlikuje vrednosni pluralizam od moralnog i kulturnog relativizma.
WORLD TRENDS FROM 2022
Authors: Jankovic Slobodan
Published: September 2022

This paper, divided in three chapters of uneven length, analyses the world trends in near future. Forecasting major processes at the global scale is a key task of the IR discipline. Author asks the question whether current world order restructuring is causing the outbreak of the new World War. In order to answer the question, he first underlines importance of forecasting, and explains what the world war is. Author claims that approach according to which it is required to have theoretical background in order to make scientific prediction is erroneous. The closest there is to objective framework is according to the author, to employ Italian neoclassical geopolitical school. In the article, author questions international and national, societal, political and only briefly economic trends in the collective West and in the Middle East. He presents the reasons why BRICS, or the East and South are growing and leading the change in major power redistribution in the framework of the new multipolar world order.
Alteraciones metabólicas y circadianas en personal de enfermería de un hospital público del noroeste de México
Authors: Zepeda-Ríos P.A. , Quintana-Zavala M.O. , López-Teros V. , Candia-Plata M.C. , Bautista-Jacobo A. , García-Puga J.A.
Published: September 2022

Introducción: Las alteraciones metabólicas se vinculan a los ritmos biológicos, dado que estos sistemas controlan aspectos fisiológicos como patrones de sueño/vigilia, temperatura corporal, presión arterial y liberación de hormonas endocrinas.
Objetivo: Identificar la relación entre los componentes del síndrome metabólico y disincronía circadiana en personal de enfermería de un hospital público.
Métodos: Estudio correlacional. Muestra censal de 30 profesionales de enfermería de dos turnos. Para la recolección de datos se utilizaron tres cédulas: a) antecedentes biosociodemográficos y laborales; b) síndrome metabólico; c) ciclo circadiano. En el procesamiento de datos se utilizó pruebas Chi-cuadrada, R de Pearson y Rho de Spearman, se verificó el supuesto de normalidad con Shapiro-Wilk. Se contó con autorización del Comité de Ética de la institución de salud y con el consentimiento informado de participantes.
Resultados: 43.3 % del personal de enfermería cumplió con criterios diagnósticos de síndrome metabólico, 100 % del turno nocturno presentó disincronía circadiana con base en el indicador patrón de sueño. El consumo de alcohol y nivel alto de triglicéridos, mostraron relación positiva estadísticamente significativa con la presencia de insomnio (p ≤ 0.001; p ≤ 0.05).
Conclusión: El síndrome metabólico es un problema de salud con alta prevalencia entre el personal de enfermería, independientemente del nivel académico o del turno laboral. El peso y los triglicéridos fueron indicadores que mostraron relación con patrones de sueño afectados. Esto enfatiza la importancia de incidir en la prevención y tratamiento del síndrome metabólico como una prioridad en el personal de enfermería, desde la salud laboral.
Balance de la Gestión para Resultados en la CDMX (2018 - 2021) a 14 años de la Reforma Fiscal
Authors: Rodríguez Lara Juan Armando
Published: September 2022

Este artículo tiene como propósito visualizar los factores organizacionales que más influyen en la implementación de las reformas administrativas, en específico, de la reforma fiscal de 2008 en México. Se describe cómo el modelo de Gestión para Resultados se introduce en la Ciudad de México y cómo se desarrolla en su contexto, además de un análisis político-administrativo sobre sus avances y perspectivas a más de una década del inicio de su implementación.
Sugars and °Brix in honey from Apis mellifera, Melipona beecheii, and commercial honey from a local market in Mexico
Authors: Castillo-Martínez Teresa , García-Osorio Cecilia , García-Muñiz José Guadalupe , Aguilar-Ávila Jorge , Ramírez-Valverde Rodolfo
Published: September 2022

Fructose and glucose are the main sugars in honey, and their concentration is expected to correspond to the specifications of official standards. The study compared the composition of sugars and ºBrix in honey from Apis mellifera and Melipona beecheii bees, and a product marketed as bee honey in a local market. The sugar content was determined by highperformance liquid chromatography (HPLC) with a refractive index detector, and °Brix was determined using a refractometer. None of the honey analyzed had detectable levels of sucrose. The average concentration of fructose and glucose in honey was 36.4 and 28.9 g 100 g-1 for Apis mellifera, and 38.5 and 28.2 g 100 g-1 for honey from Melipona beecheii. For honey from the local market, the respective concentrations of these sugars were 7.5 and 17.0 g 100 g-1. The fructose:glucose ratio (F:G) was higher than one in Apis mellifera and Melipona beecheii honey, and 0.4 for honey from the local market. The three types of honey compared had similar values for °Brix. It is concluded that the honey under study by Apis mellifera and Melipona beecheii have similar qualities within international standards. In contrast, the product marketed as bee honey in the local market did not meet official regulations specifications and could not be considered authentic.
KNN Algorithm for Identification of Tomato Disease Based on Image Segmentation Using Enhanced K-Means Clustering
Authors: Nasution Amir Saleh , Alvin Alvin , Siregar Ana Tince , Sinaga Monica Sari
Published: September 2022

Image segmentation is an important process in identifying tomato diseases. The technique that is often used in this segmentation is k-means clustering. One of the main problems in this technique is the case of local minima, where the cluster that is formed is not suitable due to the incorrect selection of the initial centroid. In image data, this case will have an impact on poor segmentation results because it can erase parts that are actually important to be lost or there is still background in the recognition process, which has an impact on decreasing accuracy results. In this research, a method for image segmentation will be proposed using the k-means clustering algorithm, which has been added with the cosine similarity method as the proposed contribution. The use of the cosine method will determine the initial centroid by calculating the level of similarity of each image feature based on color and dividing them into several categories (low, medium, and high values). Based on the results obtained, the proposed algorithm is able to segment and distinguish between leaf and background images with good results, with the kNN reaching a value of 94.90% for accuracy, 99.50% for sensitivity, and 93.75% for specificity. The results obtained using the kNN method with k-means segmentation obtained a value of 92.46% for accuracy, 96.30% for sensitivity, and 91.50% for specificity. The results obtained using the kNN method without segmentation obtained a value of 90.22% for accuracy, 93.30% for sensitivity, and 89.45% for specificity.
ECOLOGICAL SOLUTION OF GOODS PACKAGING FOR B2C LOGISTICS
Authors: Kvak Karol
Published: September 2022

The publication describes the development of a new method suitable for selecting an environmentally friendly packaging solution in B2C logistics, which is currently facing major challenges. The key for developing the new method is the fact that the selection process is greatly influenced by the ecological aspects of the supplier's solution and the efficiency of working with the proposed solution, as these are the key aspects of the future in logistics. In the results and discussion, we will focus on a specific company that currently uses 14-size variants of cardboard packaging. Based on our analysis, we reduced these to four variants and streamlined the process of ordering, handling and storage of cardboards. Using the OEE metrics, we calculated the feasibility of this solution, which was only at the level of 65% compared to the metrics set by the company's management. With the help of the suppliers, we have designed a new solution that was tested under the same conditions using the OEE metrics. In the test, we have reached the level of 98%, which means a 33% increase in efficiency. At the same time, this solution is highly environmentally friendly and does not use polypropylene adhesive tapes, which pollute the environment. We then compared the results and evaluated the best quotes for both types of cardboards. The newly designed solution is only 4.9% more expensive than the currently used type of cardboard. Based on the results achieved, we can conclude that the new method offers companies the most advanced approach to choosing a suitable solution for B2C logistics.
Quantum information with top quarks in QCD
Authors: Afik Yoav , Nova Juan Ramón Muñoz de
Published: September 2022

Top quarks represent unique high-energy systems since their spin correlations can be measured, thus allowing to study fundamental aspects of quantum mechanics with qubits at high-energy colliders. We present here the general framework of the quantum state of a top-antitop (tt¯) quark pair produced through quantum chromodynamics (QCD) in a high-energy collider. We argue that, in general, the total quantum state that can be probed in a collider is given in terms of the production spin density matrix, which necessarily gives rise to a mixed state. We compute the quantum state of a tt¯ pair produced from the most elementary QCD processes, finding the presence of entanglement and CHSH violation in different regions of phase space. We show that any realistic hadronic production of a tt¯ pair is a statistical mixture of these elementary QCD processes. We focus on the experimentally relevant cases of proton-proton and proton-antiproton collisions, performed at the LHC and the Tevatron, analyzing the dependence of the quantum state with the energy of the collisions. We provide experimental observables for entanglement and CHSH-violation signatures. At the LHC, these signatures are given by the measurement of a single observable, which in the case of entanglement represents the violation of a Cauchy-Schwarz inequality. We extend the validity of the quantum tomography protocol for the tt¯ pair proposed in the literature to more general quantum states, and for any production mechanism. Finally, we argue that a CHSH violation measured in a collider is only a weak form of violation of Bell's theorem, necessarily containing a number of loopholes.
Reações adversas do montelucaste no tratamento da asma pediátrica: uma revisão integrativa da literatura
Authors: Aidar Joana Trosdolf , Gomes Ana Carolina Lopacinski , Ribeiro Elaine Rossi , Czepula Alexandra , Nieto Gislayne Castro e Souza de
Published: September 2022

We analyzed the adverse reactions of montelukast when prescribed for the treatment of pediatric asthma. This is an integrative literature review using the databases: U.S. National Library of Medicine (PubMed), Virtual Health Library (BVS), SCOPUS and Business Source Complete (EBSCO), using the descriptors: "asthma", "pediatric", "montelukast" and "adverse effects", connected by the Boolean “ AND''. Articles in full were included, published in the last 5 years, written in Portuguese, English or Spanish, researched in humans and related to our objective. Those that met our exclusion criteria were excluded. Fifty-three articles were identified, of which 11 comprised the final sample of this review. Exposure to montelukast was associated with a 2-fold greater chance of neuropsychiatric reactions in one of the articles analyzed, but the studies have not yet provided a common pathophysiological explanation. Neuropsychiatric reactions were the most prevalent, representing more than 90% of the sample.
What is “Tremendo”? Several Features of the Poetics of Tremendism
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Gerasimenko Maria V.
Published: September 2022

Tremendism is a tendency of the postwar Spanish literature in the times of censorship and dictatorship formation in Francoist Spain. A Tremendist novel generally uses two kinds of time. The first one is historical present: a story usually takes place in 1940s Spain. The second one is individual past: the plot is grounded in a very personal story about an event which is shocking for the protagonist. A description of such an event alludes to the Civil War. The narration turns out to be an aposiopesis: speaking about the event retrospectively, the protagonist fails to mention the present, and at every moment reports less than he knows throughout the novel. His story about a tremendous event is akin to the process of silencing. This antagonism of word and silence, of the personal past and the historical present, creates a world in which dispute and mutual affirmation of contradictory orders is a constant. Protagonist involuntarily obeys the fatal order of things, the affect, and becomes a criminal or insane. Unlike the protagonist, his doppelganger can not only talk about the frightening phenomena but is also able to coexist with it. Interestingly, the description of the doppelganger’s death hints on practices of institutionalized violence. The death of the doppelganger, who is claiming power over the protagonist, simultaneously marks the end of the story for the main character. A change that it heralds for the protagonist at first glance seems extraordinary for him but, in fact, it only returns him to his initial circumstances. At the end of the novel, he is depicted in the state of agony, losing power over the world that he had been creating. He is balancing at the border between his personal non-existence, where his story is interrupted, and the artistic world of a more global creative consciousness, where his “self” turns out to be just a fantasy of some unknown creative will. Here ends his life story and his retrospective narrative begins.
The Experience of Reading the “Parafolklore” Text from I.P. Sakharov’s “Tales of the Russian People”
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Toporkov Andrey L.
Published: September 2022

The article analyzes one of the “parafolklore” texts published by Ivan Petrovich Sakharov (1807–1863) in his edition “Tales of the Russian people about the family life of their ancestors.” It is about a song which is interpolated into the description of the ritual “opahivanie,” designed to protect the village from the epizootic and expel the “Cow Death” from it. It has been established that the description of the rite of “ploughing” itself was created by I.P. Sakharov based on the description of this rite published twice by V.B. Bronevsky in 1827 and 1828, and I.P. Sakharov stylistically “decorated” and expanded the text of his predecessor. The song, absent in Bronevsky’s composition, is compiled by Sakharov himself, we believe, on the basis of some real “opahivaniye” songs with addition of some motives, borrowed from authentic works of Russian folklore and from “parafolklore” works of Sakharov himself. In the case of such works we are dealing with a special kind of literary stylization, involving the reworking of authentic folklore texts or composing original works on a folklore basis. At the same time, the composer pays attention not only to the form and content of his texts, but also to special techniques of misleading the reader about their origin (in this case, the “parafolklore” text is interpolated into a description of a real rite).
ANALISA PASANG SURUT MENGGUNAKAN METODE LEAST SQUARE PADA PANTAI TAMAN RIA
Authors: Suwarni Wayan
Published: September 2022

Pasang surut air laut merupakan salah satu fenomena yang bisa dijadikan referensi dalam penentuan pengelolahan wilayah pantai. Penelitian ini bertujuan untuk menentukan nilai konstituen, tipe pasang surut, dan pasang maksimum di Pantai Taman Ria. Perhitungannya menggunakan salah satu metode analisis harmonik yaitu metode Least Square. Metode Least Square adalah metode yang digunakan untuk menghitung konstituen pasang surut dari pengamatan yang dilakukan setiap jam selama waktu 15 hari. Metode ini pertama kali diterapkan dalam menganalisa pasang surut oleh Horni. Prinsip analisis pasang surut dengan metode Least Square yaitu dengan meminimkan perbedaan sinyal komposit. Kemudian menghasilkan komponen pasang surut (K1, O1 , M2, S2, N2, M4, K2, P1 dan MS4). Setelah itu dari beberapa komponen di dapatkan jenis atau tipe pasang surut berdasarkan bilangan Formzahl (F) dengan perbandingan (K1+ O1) /( M2 + S2). Dari hasil analisa diperoleh komponen pasang surut dominan adalah M2 dengan nilai amplitudo 0.5687 m. Untuk elevasi pasang surut diperoleh HHWL sebesar 2.99 m, MSL 1.17 m dan LLWL -0.49 m. Dengan mengacu kepada MLWS - 0.17 m diperoleh HHWL sebesar 3.16 m, MSL 1.34 m, LLWL -0.31 dan diperoleh jenis atau tipe pasang surut di Pantai Taman Ria yaitu campuran condong ke harian ganda dengan nilai F 0,5140 (0,25 < F < 1,50). Ini berarti dalam satu hari terjadi dua kali pasang dan dua kali surut dengan tinggi dan interval yang berbeda
PERBANDINGAN BEBAN GEMPA RENCANA HASIL ANALISIS MENGGUNAKAN METODE STATIK EKIVALEN DAN RESPON SPEKTRUM BERDASARKAN SNI 1726-2012
Authors: Annisa Aulia
Published: September 2022

Analisis beban rencana gempa dapat dilakukan dengan dua cara, yaitu secara statik dan dinamik. Secara statik, metode yang dapat digunakan adalah metode statik ekivalen dan secara dinamik, salah satu metodenya adalah metode respon spektrum. Pada tulisan ini, direncanakan struktur berupa gedung perkantoran bertingkat 6 (enam) menggunakan hasil analisis terbesar dari kedua metode tersebut. Struktur yang direncanakan merupakan struktur tahan gempa dengan sistem penahan gaya gempa berupa sistem ganda dengan rangka beton bertulang pemikul momen khusus (SRPMK) dan dinding geser beton bertulang khusus. Material struktur yang digunakan dalam perencanaan adalah beton dengan mutu f 'c = 35 MPa, baja tulangan BjTP Grade 24 (fy = 235 MPa), dan baja tulangan BjTS Grade 40 (fy = 390 MPa). Akibat beban rencana gempa yang ditambahkan pada struktur, dihasilkan simpangan antar lantai maksimum sebesar 52,068 mm untuk metode statik ekivalen dan 50,464 mm untuk metode respon spektrum, kedua nilai tersebut telah memenuhi syarat simpangan yaitu kurang dari simpangan lantai ijin sebesar 100 mm. Dari perbandingan kedua metode, diperoleh hasil terbesar adalah hasil analisis struktur menggunakan metode statik ekivalen, yang kemudian digunakan dalam perencanaan elemen struktur. Dimensi elemen struktur yang digunakan diseragamkan untuk setiap tingkat, dengan ukuran balok induk 40/60, balok anak 25/40, kolom 95/95, pelat dengan tebal 120 mm dan tebal dinding geser 300 mm
KAJIAN RISIKO BENCANA ABRASI WILAYAH PANTAI KECAMATAN GALESONG, KABUPATEN TAKALAR
Authors: Arafat Andi Muhammad Alfian
Published: September 2022

Preliminary research on the risk assessment of coastal erosion in the Galesong District. The beach is an area between land and sea where various kinds of human activities are carried out in the coastal area. In the last few years, the abrasion disaster in the coastal area of Galesong District has continued to increase, so that the facilities and houses of the residents have been damaged. Disaster risk analysis is carried out to determine the value of disaster risk and develop strategies to reduce existing disaster risks. The data analyzed in the form of secondary data originating from the research literature at the location being studied as well as the database of agencies related to the population of the Galesong District. The risk value for coastal abrasion disaster in Galesong District was obtained, then a strategy was developed to reduce the risk value for coastal abrasion disaster in Galesong District.
Stakeholder engagement and corporate performances: Empirical evidence from an emerging economy
Authors: Singh Avinash Pratap , Rahman Zillur
Published: September 2022

From inception to execution, United Nations Sustainable Development Goals (SDGs) are based on multi-stakeholder partnerships. Therefore, SDGs can be described as a pragmatic stakeholder engagement model. In this research article, the impact of the adoption of SDGs by firms on their financial, environmental, and social performance is examined. Based on the publication of sustainability reporting by firms in compliance with GRI standards, 89 selected Indian firms from the NSE 500 were included in the content analysis for data collection. In addition, multiple linear regression was used to analyse secondary data to establish an empirical relationship between SDGs adoption and corporate performance. The findings of this study revealed that the adoption of SDGs by firms is significantly and positively associated with their financial, environmental, and social performances. This article contributes to academic knowledge on sustainable development and provides important implications for researchers, practitioners, and policymakers. This article contributes to academic knowledge of sustainable development and corporate performance and provides important implications for researchers, practitioners, and policymakers
The Effects Of Online Customer Reviews And Customer Experiences On Reuse Intention Of Mobile Food Ordering Application (MFOA)
Authors: Purnomo Kristyanto Djoko , Diharto Awan Kostrad
Published: September 2022

This research was conducted in response to the research gap between some previous research by Auliya (2019), which stated that online customer reviews did not have significant effects on the reuse intention. Meanwhile, Alalwan (2020) in Hariguna & Ruangkanjanases (2020) found different results; namely, online customer reviews had a significant effect on the reuse intention. Therefore, this research objective was to determine the effects of online customer reviews and customer experiences on reuse intention through satisfaction.
The research population consisted of Mobile Food Ordering Application (MFOA) users in Central Java with a total sample of 251 respondents. This research used a random sampling technique. Furthermore, the data analysis of this research used the Smart PLS 3.0 application. The research results reported that online customer reviews had a significant positive effect on satisfaction. Besides, online customer reviews, customer experience, and satisfaction had significant effects on reuse intention. There were two points related to the indirect relationship in this research; namely, both online customer review and customer experience had significant effects on reuse intention through satisfaction.
Variation in clinical practice guidelines for use of palivizumab in preventing severe respiratory syncytial viral (RSV) disease in high-risk infants
Authors: Stiboy Eunice , Chan Mei , Islam Md Saiful , L Gemma Saravanos , Lui Kei , Jaffe Adam , Homaira Nusrat
Published: September 2022

Background: Uniformity and compliance with clinical practice
guidelines (CPGs) for use of palivizumab in preventing severe RSV
infection in Australian high-risk infants remain unclear.
Methods: An online survey was conducted across the Australian and
New Zealand Neonatal Network (ANZNN) to determine clinical practices
around palivizumab. A literature search was also performed to identify
and compare national and international guidelines. Results:
Sixty-five of 422 ANZNN members completed the survey. Respondents
included 61 senior medical staff of consultants/staff specialists (78%)
and four nursing staff (6%). Infants most likely to be recommended
palivizumab included preterm infants born <29 weeks
gestational age (GA) (30%), children with chronic lung diseases (CLD)
born <32 weeks GA (40%), and with hemodynamically significant
heart disease (35%). Many respondents (53%) stated that CPGs for
palivizumab were developed locally. Twenty guidelines (10 international
and 10 domestic) were obtained in total; 16(80%) recommended
palivizumab use in preterm infants, 16(80%) recommended use in infants
with CLD, 17(85%) congenital heart disease (CHD) and six (30%)
bronchopulmonary dysplasia (BPD). Eight (40%) guidelines provided
specific recommendations for immunocompromised infants. Canada, Western
Australia, and American Academy of Paediatrics provided recommendations
for Indigenous children. Frequency and dosage of palivizumab was
universal across all CPGs. None of the international guidelines obtained
were from low- or middle-income countries. Conclusions:
Standardisation of CPGs may improve clinical decision making around use
of palivizumab in high-risk infants.
Runs of homozygosity reveal past bottlenecks and contemporary inbreeding across diverging island populations of a bird
Authors: Martin Claudia , Sheppard Eleanor , Illera Juan Carlos , Suh Alexander , Nadachowska-Brzyska Krystyna , Spurgin Lewis , Richardson David
Published: September 2022

Genomes retain evidence of the demographic history and evolutionary
forces that have shaped populations. Across island systems, contemporary
patterns of genetic diversity reflect complex population demography,
including colonisation events, bottlenecks, gene flow and genetic drift.
Here, we investigate whether island founder events have prolonged
effects on genome-wide diversity and runs of homozygosity (ROH)
distributions, using whole genome resequencing from six populations
across three archipelagos of Berthelot’s pipit (Anthus
berthelotii) - a passerine which has undergone island speciation
relatively recently. Pairwise sequential Markovian coalescent (PSMC)
analyses estimated divergence from its sister species approximately two
million years ago. Results indicate that all Berthelot’s pipit
populations had shared ancestry until approximately 50,000 years ago,
when the Madeiran archipelago populations were founded, while the
Selvagens were colonised within the last 8,000 years. We identify
extensive long ROH (>1 Mb) in genomes in the most recently
colonised populations of Madeira and Selvagens which have experienced
sequential island founder events and population crashes. Population
expansion within the last 100 years may have eroded long ROH in the
Madeiran archipelago, resulting in a prevalence of short ROH
(<1 Mb). Extensive long and short ROH in the Selvagens
reflects strong recent inbreeding, small contemporary effective
population size and past bottleneck effects, with as much as 37.7% of
the autosomes comprised of ROH >250 kb in length. These
findings highlight the importance of demographic history, as well as
selection and genetic drift, in shaping contemporary patterns of genomic
diversity across diverging populations.
Isolated Accessory Tricuspid Valve Leaflet in Asymptomatic Adult.
Authors: Essa Amr , Inampudi Jyothik V. , Yirerong Juliet , Sharma Gyanendra , Gavlinksi Sheena
Published: September 2022

Accessory tricuspid valve (ATV) is a rare congenital anomaly that is
often seen in complex congenital anomalies in children with very few
reported cases in adults. We report a case of isolated ATV in an
asymptomatic adult with no other congenital defects along with
illustrative transesophageal echocardiographic 2D, 3D, high-resolution
photo-realistic images.
Antisemitism online: History’s oldest hatred and new media challenges
Authors: Milanovic Aleksa
Published: September 2022

In this text I examine the online presence of antisemitism and the ways it is spreading on a global level. I focus on different forms of antisemitism, distributed through numerous social network platforms. I also dwell on the possible causes of this phenomenon, with all its consequences. Antisemitism has always been present in public discourse, and thus its presence in online space is not new or unusual, but what surprises is certainly a significant failure of responsible institutions to prevent this phenomenon and punish perpetrators. In the last ten years, the level of online antisemitism has significantly risen. Covert and overt types of antisemitism on social networks represent a serious social problem, and a threat directed not only towards the Jewish community, but also towards every society that fosters the values of human rights, equality, peaceful communication and non-violence in all its forms.
Bioequivalence Study of Two Formulations of Cefixime
Authors: E Setiawati
Published: September 2022

Cefixime is a broad-spectrum oral antibiotic used for treating a wide variety of bacterial infections. Study Objective: The objective of this study was to find out whether bioequivalence study of Cefixime 200 mg, Profim® capsule manufactured by PT Promedrahardjo Farmasi Industri in comparison with Cefixime 100 mg, Cefspan® capsule manufactured by PT Dankos Farma, For PT Kalbe Farma Tbk, under license by Astellas Pharma Inc., Osaka – Japan. Methods: The study was conducted using an open-label, randomized, single-dose, two-periods, two-treatments, crossover study under fasting conditions with 8 (eight) days washed-out period between each period. According to the random design, a single oral dose of the test drug or reference drug was administered to 30 healthy male subjects after overnight fasting. The number of subjects who finished the study was twenty-eight (28) healthy male subjects. Serial plasma samples were obtained over a 32 hours period. Plasma concentrations of the drug were determined by LC-MS/MS method. From the Cefixime concentration vs. time curves, the following pharmacokinetic parameters were obtained: AUC0-32h, AUC0-∞, and Cmax, while the statistical interval proposed was 80.00 - 125.00% for AUC0-32h and Cmax with 90% Confidence Interval (CI) with α = 5.00%. The estimation of Tmax and T1/2 in the bioequivalence study was based on a nonparametric statistical procedure on the original data using Wilcoxon Sign Test. Results: The main pharmacokinetic parameters of the test drug Profim® (BN: B051A21P-1)/ reference drug, Cefspan® (BN: KCEFB00038) ratio were as follows: AUC0-32h: 105.86 (95.41 - 117.44) with CV Intra Subjects was 22.72% and Cmax: 105.63 (95.33 - 117.03) with CV Intra Subjects was 22.43 %. Whilst TMAX of the test drug Profim® (BN: B051A21P-1)/ reference drug, Cefspan® (BN: KCEFB00038) were respectively 4.50 (3.50 – 6.00) h and 4.50 (3.00 – 6.00) h; mean T1/2 were respectively 4.18 ± 0.78 h and 4.14 ± 0.56 h; and mean Slope were respectively (-0.17) ± 0.03 h and (-0.17) ± 0.02 h. There is no adverse event that occurred during this study. Conclusion: The present study demonstrated that the evaluated test drug Profim® (BN: B051A21P-1) were bioequivalence in term of both rate and extent of absorption to the reference drug Cefspan® (BN: KCEFB00038).
Bioequivalence Study of Etoricoxib 120 mg in Healthy Subjects
Authors: E Setiawati
Published: September 2022

Etoricoxib is an oral selective cyclo-oxygenase-2 (COX-2) inhibitor with anti-inflammatory and antirheumatic properties belonging to the group of NSAIDs. Study Objective: The objective of this study was to investigate the bioequivalence study of Etoricoxib, Tricox® 120 mg film coated caplet manufactured by PT Guardian Pharmatama for PT Nulab Pharmaceutical Indonesia in comparison with Etoricoxib 120 mg, Arcoxia® film coated tablet manufactured by Frosst Iberica, S.A., Spain, registered and packed by PT Merck Sharp Dohme Pharma Tbk Pasuruan, East Java. Indonesia. Methods: The study was conducted using an open-label, randomized, single-dose, two-periods, two-treatment, crossover study under fasting for 10 hours with 7 (seven) days washed-out period between each period. A single oral dose of the test drug or reference drug was administered to 16 healthy male subjects. The number of subjects who finished the study was fourteen (14) healthy male subjects. Serial plasma samples were obtained over a 72 hours period. Plasma concentrations of the drug were determined by LC-MS/MS method. From the Etoricoxib concentration vs. time curves, the following pharmacokinetic parameters were obtained: AUC0-72h, AUC0-∞, and Cmax, while the statistical interval proposed was 80.00 - 125.00% for AUC0-72h and Cmax with 90% Confidence Interval (CI) with α = 5.00%. The estimation of Tmax and T1/2 in the bioequivalence study was based on a nonparametric statistical procedure on the original data using Wilcoxon Sign Test. Results: The main pharmacokinetic parameters of the test drug Tricox® (BN: T200909) compared to reference drug, Arcoxia® (BN: T015857) were calculated based on geometric mean ratio and 90% confidence interval (CI). The results for AUC0-72h and Cmax were 91.97% (87.50% – 96.66%) and 96.98% (88.41% – 106.36%) respectively, with intra-subject variability (%CV) were 13.56% for AUC0-72h and 7.28% for Cmax. Hence, the number of 14 (fourteen) subjects has adequate number for required power of study. Conclusion: The study demonstrated that the test drug Tricox® (BN: T200909) manufactured by PT Guardian Pharmatama for PT Nulab Pharmaceutical Indonesia bioequivalence in term of both rate and extent of absorption to the reference drug Arcoxia® (BN: T015857) manufactured by Frosst Iberica, S.A., Spain, registered and packed by PT Merck Sharp Dohme Pharma Tbk Pasuruan, East Java. Indonesia.
Evaluation of Vitamin D Receptor (VDR) Expression and Telomerase Activity after Treatment with the Biofield Energy Treated Proprietary Test Formulation in Unpredictable Chronic Stress (UCS)-Induced Sprague Dawley Rats
Authors: Jana Snehasis
Published: September 2022

Vitamin D receptor (VDR) expression and telomerase enzyme activity was performed in the unpredictable chronic stress (UCS) model for the evaluation of Consciousness Energy Healing Treatment (the Trivedi Effect®) on a novel test formulation in male Sprague Dawley (SD) rats using ELISA assay. A unique test formulation of minerals (Zn, Fe, Cu, Se, Ca, Mg), vitamins (C, E, B6 , B12, D3 ), and nutraceuticals (β-carotene, ginseng, and cannabidiol isolate) was formulated. The constituents of the test formulation were divided into two parts; one section was defined as the untreated test formulation, while the other portion of the test formulation and three group of animals were received Biofield Energy Healing Treatment by a renowned Biofield Energy Healer, Mr. Mahendra Kumar Trivedi. VDR in liver showed an increased expression in the Biofield Energy Treated Test formulation to the untreated rats (G5), G7 (15-days pre-treatment of Biofield Energy Treated Test formulation), and G8 (15 days pre-treatment of Biofield Energy Treated test formulation to the Biofield Energy Treatment per se rats) groups by 16.7%, 75.7%, and 14.3%, respectively as compared with the untreated test formulation group (G4). Similarly, the VDR expression in kidney was increased by 22.3% and 13.6% in the G6 (Biofield Energy Treatment per se to the rats) and G8 groups, respectively, as compared with the G4. However, the VDR expression in heart was altered by 20.2%, 26%, and 28.2% in the G5, G7, and G8 groups respectively, as compared with the G4. The telomerase activity in the brain was significantly increased by 16.9%, 116%, 258.6% (p≤0.01), 148.1%, and 54.7% in the G5, G6, G7, G8, and G9 (untreated test formulation to the Biofield Energy Treatment per se to the rats) groups respectively, as compared with the G4. Similarly, telomerase activity in heart was also increased by 11.1% in the G8 group as compared with the G4. Overall, the experimental data suggested significance effect of Biofield Energy per se along with preventive measure on the animal with respect to various stress-related disorders. Overall, the results showed the significant slowdown the stress-related disease progression and its complications/symptoms in the preventive Biofield Energy Treatment group per se and/or Biofield Energy Treated Test formulation groups (viz. G6, G7, G8, and G9) as compared to the disease control and untreated test formulation groups
Evaluation of Inflammatory Serum Biomarkers after Treatment with the Consciousness Energy Healing-Based Proprietary Test Formulation on L-NAME and High Fat Diet-Induced Cardiovascular Disorders in Sprague Dawley Rats
Authors: MK Trivedi
Published: September 2022

The aim of this experiment was to evaluate the anti-inflammatory potential of Biofield Energy Treated/Blessed Proprietary Test Formulation and Biofield Energy Treatment per se to the animals on L-NAME and high fat diet (HFD)-induced cardiovascular disorders in Sprague Dawley rats using serum biomarkers. In this experiment various proinflammatory cytokines such as TNF-α, IL-6, IL-18, and IL-1β, along with C - reactive protein (CRP) using ELISA assay. A test formulation was formulated including minerals (magnesium, zinc, copper, calcium, selenium, and iron), vitamins (ascorbic acid, pyridoxine HCl, vitamin B9 , vitamin B12, and vitamin D3 ), cannabidiol (CBD) isolate, Panax ginseng extract, and β-carotene. The constituents of the test formulation were divided into two parts; one part was denoted as the untreated, while the other part and three groups of animals received Biofield Energy Healing Treatment/Blessing remotely for about 3 minutes by a renowned Spiritual Energy Healer, Mr. Mahendra Kumar Trivedi. The cytokines estimation results showed that the level of tumour necrosis factor-alpha (TNF-α) was reduced by 12.72% in the G7 (L-NAME + HFD + the Biofield Energy Treated test formulation from day -15) group as compared to the disease control (L-NAME + HFD + 0.5% CMC) group (G2). Moreover, the level of interleukin-6 (IL-6) was reduced by 31.75%, 15.96%, 24.18%, and 24.11% in the G5 (L-NAME + HFD + the Biofield Energy Treated test formulation), G6 (L-NAME + HFD + Biofield Energy Treatment per se to animals from day -15), G8 (L-NAME + HFD + Biofield Energy Treatment per se plus the Biofield Energy Treated test formulation from day -15), and G9 (L-NAME + HFD + Biofield Energy Treatment per se animals plus the untreated test formulation) groups, respectively, as compared to the G2 group. Additionally, the level of interleukin-18 (IL-18) was decreased minimally in the treatment group as compared to the G2 group. The level of IL-1β was decreased by 7.93%, 8.35%, 7.93%, 6.68%, and 6.68% in the G5, G6, G7, G8, and G9 groups, respectively as compared to the untreated test formulation (G4). Besides, the level of CRP was decreased by 33.25%, 25.78%, 15.63%, 42.12%, and 35.40% in the G5, G6, G7, G8, and G9 groups, respectively as compared to the G2 group. Overall, the data suggested significance antiinflammatory potentials of the Biofield Energy Treated/Blessed test formulation and Biofield Energy Treatment per se along with preventive measure on the animal with respect to various inflammatory conditions that might be beneficial various types of cardiovascular disorders. Therefore, the results showed the significant slowdown the inflammation-related cardiovascular disease progression and its complications in the preventive treatment groups (viz. G6, G7, G8, and G9).
The Miniature Macula-Ephelis
Authors: Bajaj Anubha
Published: September 2022

An ephelis is a miniature, benign, brown or tan cutaneous blemish which appears upon sun exposed surfaces. Genetic composition and cutaneous subtype of incriminated individual directs the emergence of ephelis. Generally spherical, ephelis demonstrates a localized area of hyperpigmentation contingent to magnitude of sun exposure. Superimposed stratified squamous epithelium exhibits hyperpigmentation of basal keratinocytes and elongation of rete ridges whereas quantifiable melanocytes remain unaltered. Ephelis requires segregation from conditions such as café-au-lait macules, junctional nevus, solar lentigo, melano-acanthoma, melanosis, moles, sun spots, liver spots and malignant epithelial neoplasms. The innocuous ephelis does not require treatment although protection from sun exposure is recommended.
Lung Cancer Therapeutics Landscape, A Current Overview
Authors: Narayan Sarcar Subha
Published: September 2022

Lung cancer is the leading cause of death across the world, both among men and women. According to the CDC, Center for Disease Control and Prevention, every year, about 200,000 people are diagnosed and about 150,000 people die because of lung cancer. Lung cancer begins in the lungs, a pair of respiratory organs in the thoracic cavity. Majority of the lung cancers are carcinogenic in nature, which means the uncontrolled tumor cell growth causes malignant tumor cells, eventually spread out from the lungs to the nearby lymph nodes and possibly to other organs, for example, the brain. Two major types of lung cancers are small cell and non-small cell lung cancers. Non-small cell lung cancer constitutes 80 to 90% of all lung cancers and can further be subdivided into adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. These different types of lung cancers develop differently, grow differently, and are treated differently. Cigarette smoking has been attributed to the number one cause of lung cancer across the world and links to almost 80 to 90% of all lung cancers. Historically, lung cancers have been treated, using conventional therapies which include resection surgery, radiotherapy, and chemotherapies. Recent advancement in science lead to targeted therapies for lung cancer, which includes ALK inhibitors, EGFR inhibitors, VEGF inhibitors, and immunotherapies. This review delves into the recent advancement in the lung cancer therapeutic landscape and discusses recent treatment strategies and options available to the patients. This review also discusses new therapies in the pipeline for lung cancers including allogeneic vaccines. Peptide or protein vaccines, autologous dendritic cell vaccines, DNA vaccines, vector-based vaccines, CAR-T therapies, and Heme-sequestering proteins, which are used to target cancer cells.
Toward A Better Screening for Cervical Cancer
Authors: Victor Manuel Vargas Hernandez
Published: September 2022

As cervical cancer screening changes from cytology or Pap test to high-risk human papillomavirus (HPV-ar) test, primary worldwide, effective classification tests to decide who of the positive HPV-ar women should receive additional diagnostic evaluation to avoid unnecessary colposcopies and biopsies; with the evaluation of the performance of the dual staining p16 / Ki-67; and partial genotyping, HPV-16/18 for the triage of women with HPV-ar, positive; for the detection of cervical intraepithelial neoplasia grade 3 or more severe (CIN-3 +) and CIN grade 2 or more severe (CIN-2+), diagnosed within 3 years after taking the sample; better risk stratification for CIN-3+ was demonstrated, compared to Pap; in women with positive results they have a higher risk than with Pap, for CIN-3 + (12.0 vs. 10.3%; 11.6%; P = .005); even with better risk stratification for CIN-3+, compared with Pap in women with HPV-ar, positive, regardless of genotype. The greatest balance against CIN-3+ was observed in HPV-16/18 negative women or with dual negative staining, with a low risk to extend the screening intervals. Double staining triage strategies required substantially fewer colposcopies for the detection of CIC-3+ compared to Pap, with a 32.1% reduction in colposcopies compared to the triage strategy currently recommended in the detection of HPV-ar, with the Pap. The results for CIN-2+ are similar. Conclusions; the management of women with HPV-ar test, positive in the detection of cervical cancer; with support from the Pap and dual staining p16 / Ki-67, alone or in combination with HPV- 16/18 genotyping, it provides better risk stratification than strategies based only on the Pap and in countries such as Mexico, where there is organized infrastructure can detect and prevent the cervical cancer.