bluuebunny/crossref_metadata_2025 huggingface dataset:
Tip60-mediated lipin 1 acetylation and ER translocation determine triacylglycerol synthesis rate
Authors: Li Terytty Yang , Song Lintao , Sun Yu , Li Jingyi , Yi Cong , Lam Sin Man , Xu Dijin , Zhou Linkang , Li Xiaotong , Yang Ying , Zhang Chen-Song , Xie Changchuan , Huang Xi , Shui Guanghou , Lin Shu-Yong , Reue Karen , Lin Sheng-Cai
Published: May 2018

Obesity is characterized by excessive fatty acid conversion to triacylglycerols (TAGs) in adipose tissues. However, how signaling networks sense fatty acids and connect to the stimulation of lipid synthesis remains elusive. Here, we show that homozygous knock-in mice carrying a point mutation at the Ser86 phosphorylation site of acetyltransferase Tip60 (Tip60
SA/SA
) display remarkably reduced body fat mass, and Tip60
SA/SA
females fail to nurture pups to adulthood due to severely reduced milk TAGs. Mechanistically, fatty acids stimulate Tip60-dependent acetylation and endoplasmic reticulum translocation of phosphatidic acid phosphatase lipin 1 to generate diacylglycerol for TAG synthesis, which is repressed by deacetylase Sirt1. Inhibition of Tip60 activity strongly blocks fatty acid-induced TAG synthesis while Sirt1 suppression leads to increased adiposity. Genetic analysis of loss-of-function mutants in Saccharomyces cerevisiae reveals a requirement of ESA1, yeast ortholog of Tip60, in TAG accumulation. These findings uncover a conserved mechanism linking fatty acid sensing to fat synthesis.
Publisher Correction: Combination therapy for tuberculosis treatment: pulmonary administration of ethionamide and booster co-loaded nanoparticles
Authors: Costa-Gouveia Joana , Pancani Elisabetta , Jouny Samuel , Machelart Arnaud , Delorme Vincent , Salzano Giuseppina , Iantomasi Raffaella , Piveteau Catherine , Queval Christophe J. , Song Ok-Ryul , Flipo Marion , Deprez Benoit , Saint-André Jean-Paul , Hureaux José , Majlessi Laleh , Willand Nicolas , Baulard Alain , Brodin Priscille , Gref Ruxandra
Published: May 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Publisher Correction: Sudden emergence of human infections with H7N9 avian influenza A virus in Hubei province, central China
Authors: Liu Jiafa , Xu Junqiang , Liu Linlin , Wei Xiaoman , Song Yi , Fang Bin , Yu Xiao , Li Xiang , Ye Guojun , Du Yingying , Chen Mingyue , Shi Weifeng , Liu Di , Holmes Edward C. , Cui Jie
Published: May 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Linguistic measures of chemical diversity and the “keywords” of molecular collections
Authors: Woźniak Michał , Wołos Agnieszka , Modrzyk Urszula , Górski Rafał L. , Winkowski Jan , Bajczyk Michał , Szymkuć Sara , Grzybowski Bartosz A. , Eder Maciej
Published: May 2018

Computerized linguistic analyses have proven of immense value in comparing and searching through large text collections (“corpora”), including those deposited on the Internet – indeed, it would nowadays be hard to imagine browsing the Web without, for instance, search algorithms extracting most appropriate keywords from documents. This paper describes how such corpus-linguistic concepts can be extended to chemistry based on characteristic “chemical words” that span more than traditional functional groups and, instead, look at common structural fragments molecules share. Using these words, it is possible to quantify the diversity of chemical collections/databases in new ways and to define molecular “keywords” by which such collections are best characterized and annotated.
FABRICA: A Bioreactor Platform for Printing, Perfusing, Observing, & Stimulating 3D Tissues
Authors: Smith Lester J. , Li Ping , Holland Mark R. , Ekser Burcin
Published: May 2018

We are introducing the FABRICA, a bioprinter-agnostic 3D-printed bioreactor platform designed for 3D-bioprinted tissue construct culture, perfusion, observation, and analysis. The computer-designed FABRICA was 3D-printed with biocompatible material and used for two studies: (1) Flow Profile Study: perfused 5 different media through a synthetic 3D-bioprinted construct and ultrasonically analyzed the flow profile at increasing volumetric flow rates (VFR); (2) Construct Perfusion Study: perfused a 3D-bioprinted tissue construct for a week and compared histologically with a non-perfused control. For the flow profile study, construct VFR increased with increasing pump VFR. Water and other media increased VFR significantly while human and pig blood showed shallow increases. For the construct perfusion study, we confirmed more viable cells in perfused 3D-bioprinted tissue compared to control. The FABRICA can be used to visualize constructs during 3D-bioprinting, incubation, and to control and ultrasonically analyze perfusion, aseptically in real-time, making the FABRICA tunable for different tissues.
The Fate of Lipid Biosignatures in a Mars-Analogue Sulfur Stream
Authors: Tan Jonathan , Lewis James M. T. , Sephton Mark A.
Published: May 2018

Past life on Mars will have generated organic remains that may be preserved in present day Mars rocks. The most recent period in the history of Mars that retained widespread surface waters was the late Noachian and early Hesperian and thus possessed the potential to sustain the most evolved and widely distributed martian life. Guidance for investigating late Noachian and early Hesperian rocks is provided by studies of analogous acidic and sulfur-rich environments on Earth. Here we report organic responses for an acid stream containing acidophilic organisms whose post-mortem remains are entombed in iron sulphates and iron oxides. We find that, if life was present in the Hesperian, martian organic records will comprise microbial lipids. Lipids are a potential sizeable reservoir of fossil carbon on Mars, and can be used to distinguish between different domains of life. Concentrations of lipids, and particularly alkanoic or “fatty” acids, are highest in goethite layers that reflect high water-to-rock ratios and thus a greater potential for habitability. Goethite can dehydrate to hematite, which is widespread on Mars. Mars missions should seek to detect fatty acids or their diagenetic products in the oxides and hydroxides of iron associated with sulphur-rich environments.
De novo characterization of Phenacoccus solenopsis transcriptome and analysis of gene expression profiling during development and hormone biosynthesis
Authors: Arya Surjeet Kumar , Dhar Yogeshwar Vikram , Upadhyay Santosh Kumar , Asif Mehar Hasan , Verma Praveen Chandra
Published: May 2018

The cotton mealybugPhenacoccus solenopsisis a devastating pest of cotton causing tremendous loss in the yield of crops each year. Widespread physiological and biological studies onP. solenopsishave been carried out, but the lack of genetic information has constrained our understanding of the molecular mechanisms behind its growth and development. To understand and characterize the different developmental stages, RNA-Seq platform was used to executede-novotranscriptome assembly and differential gene expression profiling for the eggs, first, second, third instar and adult female stages. About 182.67 million reads were assembled into 93,781 unigenes with an average length of 871.4 bp and an N50 length of 1899 bp. These unigenes sequences were annotated and classified by performing NCBI non-redundant (Nr) database, Kyoto Encyclopedia of Genes and Genomes (KEGG) and Clusters of Orthologous Groups (COG), Gene ontology (GO), the Swiss-Prot protein database (Swiss-Prot), and nearest related organismAcyrthosiphon pisum(pea aphid) database. To get more information regarding the process of metamorphosis, we performed a pairwise comparison of four developmental stages and obtained 29,415 differentially expressed genes. Some of the differentially expressed genes were associated with functional protein synthesis, anti-microbial protection, development and hormone biosynthesis. Functional pathway enrichment analysis of differentially expressed genes showed the positive correlation with specific physiological activities of each stage, and these results were confirmed by qRT-PCR experiments. This study gives a valuable genomics resource ofP. solenopsiscovering all its developmental stages and will promote future studies on biological processes at the molecular level.
Homotypic endothelial nanotubes induced by wheat germ agglutinin and thrombin
Authors: Pedicini Lucia , Miteva Katarina T. , Hawley Verity , Gaunt Hannah J. , Appleby Hollie L. , Cubbon Richard M. , Marszalek Katarzyna , Kearney Mark T. , Beech David J. , McKeown Lynn
Published: May 2018

Endothelial barrier formation is maintained by intercellular communication through junctional proteins. The mechanisms involved in maintaining endothelial communication subsequent to barrier disruption remain unclear. It is known that low numbers of endothelial cells can be interconnected by homotypic actin-driven tunneling nanotubes (TNTs) which could be important for intercellular transfer of information in vascular physiology. Here we sought insight into the triggers for TNT formation. Wheat germ agglutinin, a C-type lectin and known label for TNTs, unexpectedly caused striking induction of TNTs. A succinylated derivative was by contrast inactive, suggesting mediation by a sialylated protein. Through siRNA-mediated knockdown we identified that this protein was likely to be CD31, an important sialylated membrane protein normally at endothelial cell junctions. We subsequently considered thrombin as a physiological inducer of endothelial TNTs because it reduces junctional contact. Thrombin reduced junctional contact, redistributed CD31 and induced TNTs, but its effect on TNTs was CD31-independent. Thrombin-induced TNTs nevertheless required PKCα, a known mediator of thrombin-dependent junctional remodelling, suggesting a necessity for junctional proteins in TNT formation. Indeed, TNT-inducing effects of wheat germ agglutinin and thrombin were both correlated with cortical actin rearrangement and similarly Ca2+-dependent, suggesting common underlying mechanisms. Once formed, Ca2+ signalling along TNTs was observed.
Possible causes of data model discrepancy in the temperature history of the last Millennium
Authors: Neukom Raphael , Schurer Andrew P. , Steiger Nathan. J. , Hegerl Gabriele C.
Published: May 2018

Model simulations and proxy-based reconstructions are the main tools for quantifying pre-instrumental climate variations. For some metrics such as Northern Hemisphere mean temperatures, there is remarkable agreement between models and reconstructions. For other diagnostics, such as the regional response to volcanic eruptions, or hemispheric temperature differences, substantial disagreements between data and models have been reported. Here, we assess the potential sources of these discrepancies by comparing 1000-year hemispheric temperature reconstructions based on real-world paleoclimate proxies with climate-model-based pseudoproxies. These pseudoproxy experiments (PPE) indicate that noise inherent in proxy records and the unequal spatial distribution of proxy data are the key factors in explaining the data-model differences. For example, lower inter-hemispheric correlations in reconstructions can be fully accounted for by these factors in the PPE. Noise and data sampling also partly explain the reduced amplitude of the response to external forcing in reconstructions compared to models. For other metrics, such as inter-hemispheric differences, some, although reduced, discrepancy remains. Our results suggest that improving proxy data quality and spatial coverage is the key factor to increase the quality of future climate reconstructions, while the total number of proxy records and reconstruction methodology play a smaller role.
Ecosystem functions including soil organic carbon, total nitrogen and available potassium are crucial for vegetation recovery
Authors: Qiu Kaiyang , Xie Yingzhong , Xu Dongmei , Pott Richard
Published: May 2018

The effects of biodiversity on ecosystem functions have been extensively studied, but little is known about the effects of ecosystem functions on biodiversity. This knowledge is important for understanding biodiversity-ecosystem functioning relationships. Desertification reversal is a significant global challenge, but the factors that play key roles in this process remain unclear. Here, using data sampled from areas undergoing desertification reversal, we identify the dominant soil factors that play a role in vegetation recovery with ordinary least squares and structural equation modelling. We found that ecosystem functions related to the cycling of soil carbon (organic C, SOC), nitrogen (total N, TN), and potassium (available K, AK) had the most substantial effects on vegetation recovery. The effects of these ecosystem functions were simultaneously influenced by the soil clay, silt and coarse sand fractions and the soil water content. Our findings suggest that K plays a critical role in ecosystem functioning and is a limiting factor in desertification reversal. Our results provide a scientific basis for desertification reversal. Specifically, we found that plant biodiversity may be regulated by N, phosphorus (P) and K cycling. Collectively, biodiversity may respond to ecosystem functions, the conservation and enhancement of which can promote the recovery of vegetation.
Metagenomic profiling for assessing microbial diversity and microbial adaptation to degradation of hydrocarbons in two South African petroleum-contaminated water aquifers
Authors: Kachienga Leonard , Jitendra Keshri , Momba Maggy
Published: May 2018

Biodegradation of hydrocarbons by indigenous populations of microorganisms found in petroleum-contaminated water sources represents one of the primary mechanisms by which petroleum and other hydrocarbon pollutants are eliminated from the aquatic environment. The identification of these microorganisms, which have capabilities to convert the majority of toxic hydrocarbons into compounds that are less harmful for end-users, is therefore crucial for bioremediation purposes. The aim of this study was to profile the microbial diversity of two South African petroleum-contaminated water aquifer sites and to determine the microbial adaptation to hydrocarbon degradation using a metagenomics approach. The sequenced samples revealed that protozoa (62.04%) were found to be the most dominant group, followed by fungi (24.49%), unknown (12.87%), and finally other sequences such as Animalia and plantae which were <(0.10%) domains in the first oil-polluted aquifer site. In the second site, protozoa (61.90%), unknown (16.51%), fungi (11.41%) in that order. According to the classification at the genus level, the dominant group was Naegleria (15.21%), followed by Vorticella (6.67%) as the only ciliated protozoan genus, other species such as Arabidopsis (2.97%), Asarum (1.84%) Populus (1.04%) were significantly low and drastically lower in the first site. Regarding the second site, the dominant group was Naegleria (18.29%) followed by Colpoda (9.86%) with the remainder of the genera representing <2%. Overall results demonstrated the ability of various groups of microorganisms to adapt and survive in petroleum oil-polluted water sites regardless of their respective distributions and this can be explored further for their role in bioremediation and environmental management.
Oncological Outcome of Primary and Secondary Muscle-Invasive Bladder Cancer: A Systematic Review and Meta-analysis
Authors: Ge Peng , Wang Li , Lu Meng , Mao Lijun , Li Wang , Wen Rumin , Lin Jian , Wang Junqi , Chen Jiacun
Published: May 2018

Conflicting results of survival outcomes for primary and secondary muscle-invasive bladder cancer (MIBC) have been reported in previous studies. Primary MIBC is defined as presentation of muscle-invasive disease at initial diagnosis while secondary MIBC presumes that non-muscle invasive disease later progressed to MIBC. Due to the varying reports, we conducted a systematic review and meta-analysis to compare survival outcomes between the two groups. Relevant studies were retrieved from Medline, Embase, the Cochrane Library, and Scopus using a comprehensive search approach. Cancer-specific survival (CSS) was the outcome measure. A total of 14 studies involving 4,075 cases were included. Patients with secondary MIBC were significantly correlated with worse CSS in model I (pooled HR: 1.29, 95% CI: 1.07–1.56, P = 0.008). The results of sensitivity analyses indicated that the omission of any single study each time did not have a significant impact on the combined risk estimates. Egger’s test suggested no publication bias among these studies. The European Organization for Research and Treatment of Cancer (EORTC) risk score offers the possibility of stratifying the secondary MIBC patients into different risk groups. In high-risk NMIBC, timely radical cystectomy should be considered. Further study is required to assess the multimodal therapy in both high-risk NMIBC and secondary MIBC patients as well as to evaluate genetic and molecular drivers of tumor induction, promotion, and progression.
One novel representation of DNA sequence based on the global and local position information
Authors: Mo Zhiyi , Zhu Wen , Sun Yi , Xiang Qilin , Zheng Ming , Chen Min , Li Zejun
Published: May 2018

One novel representation of DNA sequence combining the global and local position information of the original sequence has been proposed to distinguish the different species. First, for the sufficient exploitation of global information, one graphical representation of DNA sequence has been formulated according to the curve of Fermat spiral. Then, for the consideration of local characteristics of DNA sequence, attaching each point in the curve of Fermat spiral with the related mass has been applied based on the relationships of neighboring four nucleotides. In this paper, the normalized moments of inertia of the curve of Fermat spiral which composed by the points with mass has been calculated as the numerical description of the corresponding DNA sequence on the first exons of beta-global genes. Choosing the Euclidean distance as the measurement of the numerical descriptions, the similarity between species has shown the performance of proposed method.
The high efficient catalytic properties for thermal decomposition of ammonium perchlorate using mesoporous ZnCo2O4 rods synthesized by oxalate co-precipitation method
Authors: Xiao Xuechun , Peng Bingguo , Cai Linfeng , Zhang Xuanming , Liu Sirui , Wang Yude
Published: May 2018

Mesoporous ZnCo2O4 rods have been successfully prepared via oxalate co-precipitation method without any template. The nano-sized spinel crystallites connected together to form mesoporous structure by annealing homogeneous complex oxalates precursor at a low rate of heating. It is found that the low anneal rate plays an important role for the formation of mesoporous ZnCo2O4 rods. The effects of the heat temperature on the phase, morphology and catalytic properties of the products were studied. The XRD, SEM TEM, and N2 absorption/desorption have been done to obtain compositional and morphological information as well as BET surface area of the as-prepared sample. Catalytic activities of mesoporous ZnCo2O4 rods toward the thermal decomposition of ammonium perchlorate (AP) were investigated with differential scanning calorimetry (DSC) and thermogravimetry (TG) techniques. The results show that the addition of ZnCo2O4 rods to AP dramatically reduces the decomposition temperature. The ZnCo2O4 rods annealed at 250 °C possesses much larger specific area and exhibits excellent catalytic activity (decrease the high decomposition temperature of AP by 162.2 °C). The obtained mesoporous ZnCo2O4 rods are promising as excellent catalyst for the thermal decomposition of AP.
Multiple claudin–claudin cis interfaces are required for tight junction strand formation and inherent flexibility
Authors: Zhao Jun , Krystofiak Evan S. , Ballesteros Angela , Cui Runjia , Van Itallie Christina M. , Anderson James M. , Fenollar-Ferrer Cristina , Kachar Bechara
Published: May 2018

Tight junctions consist of a network of sealing strands that create selective ion permeability barriers between adjoining epithelial or endothelial cells. The current model for tight junction strands consists of paired rows of claudins (Cldn) coupled by a cis interface (X-1) derived from crystalline Cldn15. Here we show that tight junction strands exhibit a broad range of lateral bending, indicating diversity in cis interactions. By combining protein–protein docking, coevolutionary analysis, molecular dynamics, and a mutagenesis screen, we identify a new Cldn–Cldn cis interface (Cis-1) that shares interacting residues with X-1 but has an ~ 17° lateral rotation between monomers. In addition, we found that a missense mutation in a Cldn14 that causes deafness and contributes stronger to Cis-1 than to X-1 prevents strand formation in cultured cells. Our results suggest that Cis-1 contributes to the inherent structural flexibility of tight junction strands and is required for maintaining permeability barrier function and hearing.
Structural and catalytic properties of the Au25−xAgx(SCH3)18(x= 6, 7, 8) nanocluster
Authors: Panapitiya Gihan , Wang Hong , Chen Yuxiang , Hussain Ejaz , Jin Rongchao , Lewis James P.
Published: May 2018

The structural trends in AgxAu25−xalloyed nanoclusters are studied with exhaustive high-throughput calculations and the experimental catalytic activity is explained.
Ab initio calculation of energy levels of trivalent lanthanide ions
Authors: Freidzon Alexandra Ya. , Kurbatov Ilia A. , Vovna Vitaliy I.
Published: May 2018

A fully ab initio computational scheme employing CASSCF/XMCQDPT2/SO-CASSCF for the absorption and emission spectra of trivalent lanthanide complexes is presented.
Molecular mechanism of 15-lipoxygenase allosteric activation and inhibition
Authors: Meng Hu , Dai Ziwei , Zhang Weilin , Liu Ying , Lai Luhua
Published: May 2018

An allosteric activator of 15-lipoxygenase prevents substrate inhibition by eliminating the second substrate binding site without affecting the normal enzyme catalysis.
Linseed oil-based alkyd/Cu2O nanocomposite coatings for surface applications
Authors: Selim Mohamed S. , Shenashen Mohamed A. , Hashem Ahmed I. , El-Safty Sherif A.
Published: May 2018

An ecofriendly series of linseed oil based hyperbranched alkyd/Cu2O-nanocube composites was developed as a modern stream for surface coating applications.
Characterization of mercury-binding proteins in rat blood plasma
Authors: Li Yiling , He Bin , Nong Qiying , Qu Guangbo , Liu Lihong , Shi Jianbo , Hu Ligang , Jiang Guibin
Published: May 2018

Mercury-binding protein profiles in plasmain vitroandin vivo, which were unclear previously, were systematically investigated.
A tritopic carbanionic N-heterocyclic dicarbene and its homo- and heterometallic coinage metal complexes
Authors: Zhang Fan , Cao Xiao-Ming , Wang Jiwei , Jiao Jiajun , Huang Yongming , Shi Min , Braunstein Pierre , Zhang Jun
Published: May 2018

Homo (Au3)- and heterotrinuclear coinage metal complexes (Au2Ag and Au2Cu) ligated by the first tritopic dicarbanionic NHC have been prepared by deprotonation of ditopic NHC digold complexes.
Synthesis of tetronic acids from propargylic alcohols and CO2
Authors: Shen Guo , Zhou Wen-Jun , Zhang Xiao-Bo , Cao Guang-Mei , Zhang Zhen , Ye Jian-Heng , Liao Li-Li , Li Jing , Yu Da-Gang
Published: May 2018

A direct and environmentally friendly synthesis of important tetronic acids from easily available propargylic alcohols and carbon dioxide is reported for the first time.
Enantioselective nickel-catalyzed arylative intramolecular 1,4-allylations
Authors: Nguyen Thi Le Nhon , Incerti-Pradillos Celia A. , Lewis William , Lam Hon Wai
Published: May 2018

The enantioselective desymmetrization of allenyl cyclohexa-2,5-dienones by nickel-catalyzed arylative intramolecular 1,4-allylations is described.
3D negative thermal expansion in orthorhombic MIL-68(In)
Authors: Liu Zhanning , Li Qiang , Zhu He , Lin Kun , Deng Jinxia , Chen Jun , Xing Xianran
Published: May 2018

Rare three-dimensional negative thermal expansion (NTE) has been found in a low symmetry compound, orthorhombic MIL-68(In).
Dimesitylboryl-functionalised cyanostilbene derivatives of phenothiazine: distinctive polymorphism-dependent emission and mechanofluorochromism
Authors: Arivazhagan C. , Malakar Partha , Jagan R. , Prasad Edamana , Ghosh Sundargopal
Published: May 2018

Dimesitylborane-functionalized cyanostilbene derivatives of phenothiazine exhibit polymorphism with distinct solid-state emissions.
Tuning charge-assisted and weak hydrogen bonds in molecular complexes of the proton sponge DMAN by acid co-former substitution
Authors: Saunders Lucy K. , Nowell Harriott , Spencer Helen C. E. , Hatcher Lauren E. , Shepherd Helena J. , Thomas Lynne H. , Jones Charlotte L. , Teat Simon J. , Raithby Paul R. , Wilson Chick C.
Published: May 2018

Varying the electronic character of the acid co-former substituent group predictably alters weak and strong intermolecular interactions.
Anomalous strength characteristics of Stone–Thrower–Wales defects in graphene sheets – a molecular dynamics study
Authors: Juneja Aniyush , Rajasekaran G.
Published: May 2018

This study demonstrates that the intrinsic properties of graphene sheets with STW-1 and STW-2 defects are identical irrespective of their preferred loading directions at higher strain rates and lower temperatures.
Effect of puckering motion and hydrogen bond formation on the vibrational circular dichroism spectrum of a flexible molecule: the case of (S)-1-indanol
Authors: Le Barbu-Debus Katia , Scherrer Arne , Bouchet Aude , Sebastiani Daniel , Vuilleumier Rodolphe , Zehnacker Anne
Published: May 2018

Vibrational circular dichroism spectra of (S)-1-indanol in DMSO and CCl4 are described by cluster-in-the-bulk static calculations and first principles molecular dynamics.
Acemetacin–phosphatidylcholine interactions are determined by the drug ionization state
Authors: Pereira-Leite Catarina , Nunes Cláudia , Grahl Débora , Bozelli José C. , Schreier Shirley , Kamma-Lorger Christina S. , Cuccovia Iolanda M. , Reis Salette
Published: May 2018

Complementary biophysical techniques depicted the differential effects of acemetacin ionic forms on phosphatidylcholine bilayers.
Tl2S: a metal-shrouded two-dimensional semiconductor
Authors: Shen Shiying , Liang Yan , Ma Yandong , Huang Baibiao , Wei Wei , Dai Ying
Published: May 2018

Tl2S single-layers are metal-shrouded two-dimensional semiconductors exhibiting a range of exotic properties.
Spin crossover dynamics studies on the thermally activated molecular oxygen binding mechanism on a model copper complex
Authors: Bie Lihua , Liu Fang , Li Yanwei , Dong Tiange , Gao Jun , Du Likai , Yuan Qiaoxia
Published: May 2018

The theoretical description of the primary dioxygen (O2) binding and activation step in many copper or iron enzymes, suffers from the instrinsically electronic non-adiabaticity of the spin flip events of the triplet dioxygen molecule (3O2), mediated by spin–orbit couplings.
Cocrystals of a 1,2,4-thiadiazole-based potent neuroprotector with gallic acid: solubility, thermodynamic stability relationships and formation pathways
Authors: Surov Artem O. , Churakov Andrei V. , Proshin Alexey N. , Dai Xia-Lin , Lu Tongbu , Perlovich German L.
Published: May 2018

The thermodynamic stability relationships and the formation pathways of the cocrystals of 1,2,4-thiadiazole-based neuroprotector with gallic acid were investigated.
Melamine-derived graphitic carbon nitride as a new effective metal-free catalyst for Knoevenagel condensation of benzaldehyde with ethylcyanoacetate
Authors: Shcherban N. D. , Mäki-Arvela P. , Aho A. , Sergiienko S. A. , Yaremov P. S. , Eränen K. , Murzin D. Yu.
Published: May 2018

Melamine-derived C3N4 was tested in Knoevenagel condensation of benzaldehyde with ethylcyanoacetate.
An experimental methodology to measure the reaction rate constants of processes sensitised by the triplet state of 4-carboxybenzophenone as a proxy of the triplet states of chromophoric dissolved organic matter, under steady-state irradiation conditions
Authors: Minella Marco , Rapa Lorenzo , Carena Luca , Pazzi Marco , Maurino Valter , Minero Claudio , Brigante Marcello , Vione Davide
Published: May 2018

This is an assessment of the reactivity of 4-carboxybenzophenone under steady-state irradiation.
Gram-negative Escherichia coli promotes deposition of polymer-capped silver nanoparticles in saturated porous media
Authors: Chen Fangmin , Yuan Xuemei , Song Zefeng , Xu Shangping , Yang Yuesuo , Yang Xinyao
Published: May 2018

Interaction between the AgNP coating and the cell membrane structure of Gram-negative E. coli reduces both the AgNP–cell affinity and AgNP mobility in porous media, but has little effect on the E. coli mobility. These mechanisms help to protect the bacteria against AgNP.
Reduction pathway-dependent cytotoxicity of reduced graphene oxide
Authors: Zhang Qiurong , Liu Xiaolei , Meng Hongyan , Liu Sijin , Zhang Chengdong
Published: May 2018

The environmental transformation of graphene oxide (GO) can significantly change its physicochemical properties, thus altering its toxicity.
Solar-light-driven CO2 reduction by methane on Pt nanocrystals partially embedded in mesoporous CeO2 nanorods with high light-to-fuel efficiency
Authors: Mao Mingyang , Zhang Qian , Yang Yi , Li Yuanzhi , Huang Hui , Jiang Zhongkai , Hu Qianqian , Zhao Xiujian
Published: May 2018

A unique Pt/CeO2 nanocomposite exhibits solar-light-driven thermocatalytic activity for CO2 reduction by methane with high light-to-fuel efficiency and production rates of H2 and CO.
A nitrocellulose membrane-based integrated microfluidic system for bacterial detection utilizing magnetic-composite membrane microdevices and bacteria-specific aptamers
Authors: Wu Jia-Han , Wang Chih-Hung , Ma Yu-Dong , Lee Gwo-Bin
Published: May 2018

A new, nitrocellulose-based microfluidic system featuring Acinetobacter baumannii (AB)-specific aptamers capable of automating the bacterial detection process was reported.
Double-sided 3D printing on paper towards mass production of three-dimensional paper-based microfluidic analytical devices (3D-μPADs)
Authors: Park Chanyong , Han Yong Duk , Kim Han Vit , Lee Jinkee , Yoon Hyun C. , Park Sungsu
Published: May 2018

Recently, much effort has been focused on developing three-dimensional, paper-based microfluidic analytical devices (3D-μPADs) targetingin vitrodiagnostics.
Synthesis and cellular penetration properties of new phosphonium based cationic amphiphilic peptides
Authors: Silva Nigenda Ezequiel , Postma Tobias M. , Hezwani Mohammed , Pirvan Alin , Gannon Susan , Smith Carol-Anne , Riehle Mathis , Liskamp Rob M. J.
Published: May 2018

A new category of phosphonium based cationic amphiphilic peptides has been developed and evaluated as potential antimicrobial peptides and cell penetrating peptides.
Role of arsenic (+3 oxidation state) methyltransferase in arsenic mediated APL treatment: anin vitroinvestigation
Authors: Maimaitiyiming Yasen , Wang Chao , Xu Shi , Islam Khairul , Chen Ye Jia , Yang Chang , Wang Qian Qian , Naranmandura Hua
Published: May 2018

Arsenic (+3 oxidation state) methyltransferase (AS3MT) contributes to induce the APL cell death by biotransformation of As2O3to more reactive methylated metabolites.
Review on nanoscale Bi-based photocatalysts
Authors: He Rongan , Xu Difa , Cheng Bei , Yu Jiaguo , Ho Wingkei
Published: May 2018

Recent studies on nanoscale Bi-based photocatalysts including component adjustment, morphology control, heterojunction construction and surface modification are reviewed.
Synthesis, structures and antimicrobial activity of copper derivatives ofN-substituted imidazolidine-2-thiones: unusual bio-activity againstStaphylococcus epidermidisandEnterococcus faecalis
Authors: Lobana Tarlok S. , Aulakh Jaspreet K. , Sood Heena , Arora Daljit S. , Garcia-Santos Isabel , Kaur Manpreet , Duff Courtney E. , Jasinski Jerry P.
Published: May 2018

Synthesis and antimicrobial activity of copper(i) complexes withN-substituted imidazolidine-2-thiones is investigated.
Preparation and characterization of monoliths HKUST-1 MOF via straightforward conversion of Cu(OH)2-based monoliths and its application for wastewater treatment: artificial neural network and central composite design modeling
Authors: Parsazadeh Nadieh , Yousefi Fakhri , Ghaedi Mehrorang , Dashtian Kheibar , Borousan Fatemeh
Published: May 2018

Highly crystalline water stable monolithic HKUST-1 MOF by a straightforward conversion of Cu(OH)2-based monoliths was prepared and characterized via FE-SEM, XRD and EDS analysis.
Theoretical characterization of supramolecular complexes formed by fullerenes and dimeric porphyrins
Authors: Denis Pablo A.
Published: May 2018

Intramolecular stacking is very strong in dimeric porphyrins. However, in solution they are able to inhibit folding and can trap fullerenes with very high association constants. Diabatic interaction energies can be a useful approach to evaluate the strength of porphyrin/fullerene supramolecular complexes.
Copper(i)/succinic acid cooperatively catalyzed one-pot synthesis of organoselenium-propargylamines via A3-coupling
Authors: de Oliveira Isadora M. , Pimenta Daniel C. , Zukerman-Schpector Julio , Stefani Hélio A. , Manarin Flávia
Published: May 2018

Selenium propargylamines were synthesized via an A3-coupling approach using piperidine, p-methoxybenzaldehyde, and trimethylsilyl selenium–acetylene, catalyzed by copper(i) chloride and succinic acid as an additive, in good to excellent yields.
Synthesis of multi-functional green fluorescence carbon dots and their applications as a fluorescent probe for Hg2+ detection and zebrafish imaging
Authors: Xu Quan , Zhang Miaoran , Liu Yao , Cai Wei , Yang Wenjing , He Ziying , Sun Xiuli , Luo Yan , Liu Fang
Published: May 2018

Green fluorescence carbon dots for mercury detection and zebrafish imaging.
Facile selective synthesis of 2-methyl-5-amino-1,2,4-oxadiazolium bromides as further targets for nucleophilic additions
Authors: Il’in Mikhail V. , Bolotin Dmitrii S. , Suslonov Vitalii V. , Kukushkin Vadim Yu.
Published: May 2018

The reaction of aminonitrones with isocyanides and Br2 gives 2-methyl-5-amino-1,2,4-oxadiazolium bromides, which are convenient precursors for other heterocycles and ureides.
Adsorptive removal of Cd2+ from aqueous solutions by a highly stable covalent triazine-based framework
Authors: Ghazi Zahid Ali , Khattak Abdul Muqsit , Iqbal Rashid , Ahmad Rashid , Khan Adnan Ali , Usman Muhammad , Nawaz Faheem , Ali Wajid , Felegari Zahra , Jan Saad Ullah , Iqbal Azhar , Ahmad Aziz
Published: May 2018

Porous crystalline materials such as covalent organic frameworks (COFs) have gained tremendous popularity in multidisciplinary areas of science and technology.
β-Carboline–imidazopyridine hybrids: selective and sensitive optical sensors for copper and fluoride ions
Authors: Swami Suman , Behera Debasis , Agarwala Arunava , Verma Ved Prakash , Shrivastava Rahul
Published: May 2018

Two rationally designed β-carboline–imidazopyridine hybrid chromofluorescent sensors S1 and S2 have been successfully synthesized and evaluated for the selective sensing of metal ions and anions.
Links between peptides and Mn oxide: nano-sized manganese oxide embedded in a peptide matrix
Authors: Najafpour Mohammad Mahdi , Madadkhani Sepideh , Akbarian Somayyeh , Zand Zahra , Hołyńska Małgorzata , Kompany-Zareh Mohsen , Tatsuya Tomo , Singh Jitendra Pal , Chae Keun Hwa , Allakhverdiev Suleyman I.
Published: May 2018

We report on a poly-peptide/Mn oxide nanocomposite as a model for the water-oxidizing catalyst in Photosystem II.
Field dependence of the ferromagnetic/superconducting proximity effect in a YBCO/STO/LCMO multilayer
Authors: Paull Oliver H. C. , Pan Alexey V. , Causer Grace L. , Fedoseev Sergey A. , Jones Antony , Liu Xinzhi , Rosenfeld Anatoly , Klose Frank
Published: May 2018

A giant ferromagnetic/superconducting proximity effect is demonstrated to be controllable by an external magnetic field.
Electrochemical polymerization of pyrene and aniline exclusively inside the pores of activated carbon for high-performance asymmetric electrochemical capacitors
Authors: Itoi Hiroyuki , Maki Shintaro , Ninomiya Takeru , Hasegawa Hideyuki , Matsufusa Hidenori , Hayashi Shinya , Iwata Hiroyuki , Ohzawa Yoshimi
Published: May 2018

Polypyrene and polyaniline are synthesized exclusively inside the pores of activated carbon for high-performance asymmetric electrochemical capacitor electrodes.
Flexible, transparent and highly sensitive SERS substrates with cross-nanoporous structures for fast on-site detection
Authors: Wang Yingcheng , Jin Yuanhao , Xiao Xiaoyang , Zhang Tianfu , Yang Haitao , Zhao Yudan , Wang Jiaping , Jiang Kaili , Fan Shoushan , Li Qunqing
Published: May 2018

A flexible and transparent SERS substrate is fabricated on a PET film and fast, on-site and ultrasensitive SERS detection is realized.
Acoustically enhanced photodetection by a black phosphorus–MoS2 van der Waals heterojunction p–n diode
Authors: Zheng Shijun , Wu Enxiu , Feng Zhihong , Zhang Rao , Xie Yuan , Yu Yuanyuan , Zhang Rui , Li Quanning , Liu Jing , Pang Wei , Zhang Hao , Zhang Daihua
Published: May 2018

We developed a new way to enhance the photoresponsivity of a van der Waals heterojunction p–n diode using surface acoustic waves (SAWs).
Promoter free allylation of trichloroacetimidates with allyltributylstannanes under thermal conditions to access the common 1,1′-diarylbutyl pharmacophore
Authors: Mahajani Nivedita S. , Chisholm John D.
Published: May 2018

Allylation of trichloroacetimidates readily provides 1,1′-diarylbutyl groups, a common pharmacophore.
Synthesis of N-[(dialkylamino)methyl]acrylamides and N-[(dialkylamino)methyl]methacrylamides from Schiff base salts: useful building blocks for smart polymers
Authors: Alzahrani Abdullah , Mirallai Styliana I. , Chalmers Benjamin A. , McArdle Patrick , Aldabbagh Fawaz
Published: May 2018

Schiff base salts are characterized and form N-amino methylated acrylamides and methacrylamides.
Facile synthesis of branched polyvinyl acetateviaredox-initiated radical polymerization
Authors: Zeng Ni , Yu Yuyan , Chen Junbing , Meng Xiao , Peng Leilei , Dan Yi , Jiang Long
Published: May 2018

Although branched polymers find widespread applications, the rational design and synthesis of branched vinyl polymersviathe conventional radical (co)polymerization of commercially available monomers is still a challenge for researchers in this field.
Short-wave infrared emitted/excited fluorescence from carbon dots and preliminary applications in bioimaging
Authors: Li Dongyu , Wang Dan , Zhao Xinyuan , Xi Wang , Zebibula Abudureheman , Alifu Nuernisha , Chen Jian-Feng , Qian Jun
Published: May 2018

The fluorescence characteristics of carbon dots based on the short-wave infrared (SWIR) spectral range were investigated. SWIR emissions from the fluorescent carbon dots were used for in vivo imaging.
Geographical patterns of denitrifying bacterial communities associated with different urban lakes
Authors: Zhang Haihan , Zhao Zhenfang , Chen Shengnan , Wang Yue , Feng Ji , Jia Jingyu , Kang Pengliang , Li Sulin
Published: May 2018

The geographical variation of denitrifying bacterial communities and water quality parameters in urban lakes distributed across nine provinces in China were determined.
First-principles analysis of a molecular piezoelectric meta-nitroaniline
Authors: Wang Fu , Dai Zelin , Gu Yu , Cheng Xiaomeng , Jiang Yadong , Ouyang Fangping , Xu Jimmy , Xu Xiangdong
Published: May 2018

The piezoelectric and elastic properties of a molecular piezoelectric meta-nitroaniline (mNA) in its single-crystal form were investigated in the framework of first-principles density functional perturbation theory (DFPT).
δ-Carboline-based bipolar host materials for deep blue thermally activated delayed fluorescence OLEDs with high efficiency and low roll-off characteristic
Authors: Moon Ji Su , Ahn Dae Hyun , Kim Si Woo , Lee Seung Yeon , Lee Ju Young , Kwon Jang Hyuk
Published: May 2018

We report two new bipolar host materials with ~3.0 eV high triplet energy. Fabricated deep blue TADF OLEDs with these hosts exhibited external quantum efficiency as high as 22.9% and low efficiency roll-off (19.2% at 1000 cd m–2).
Tough interpenetrating polymer network of silicone containing polyurethane and polystyrene with self-healing, shape memory and self-cleaning attributes
Authors: Ghosh Tuhin , Karak Niranjan
Published: May 2018

A tough IPN of silicone containing polyurethane and polystyrene with smart attributes like self-healing, shape memory and self-cleaning is reported.
Heronamides G–L, polyene macrolactams from Streptomyces niveus
Authors: Ding Nan , Han Li , Jiang Yi , Li Guiding , Zheng Zehui , Cao Bixuan , Guan Peipei , Mu Yu , Lin Bin , Huang Xueshi
Published: May 2018

New polyene macrolactams, heronamides G–L (1–6) from the fermentation broth of Streptomyces niveus.
Highly porous core–shell chitosan beads with superb immobilization efficiency forLactobacillus reuteri121 inulosucrase and production of inulin-type fructooligosaccharides
Authors: Charoenwongpaiboon Thanapon , Wangpaiboon Karan , Pichyangkura Rath , Prousoontorn Manchumas Hengsakul
Published: May 2018

Inulosucrase immobilized on chitosan bead in core–shell format has proved to be an attractive biocatalyst for the synthesis of inulin-type fructooligosaccharides.
A series of water-soluble photosensitizers based on 3-cinnamoylcoumarin forin vitroantimicrobial photodynamic inactivation
Authors: Sun Zhiyuan , Zhou Shaona , Qiu Haixia , Gu Ying , Zhao Yuxia
Published: May 2018

Three cationic PSs (M3–M5) exhibited equivalent photodynamic inactivation (PDI) efficacies to MRSA andA. baumannii, whileM4andM5showed significantly higher PDI toC. albicans, compared to methylene blue, indicating their large potentials on PDI.
Tribological properties of attapulgite/La2O3 nanocomposite as lubricant additive for a steel/steel contact
Authors: Nan Feng , Zhou Kaihe , Liu Shuan , Pu Jibin , Fang Yunhui , Ding Wenxuan
Published: May 2018

Attapulgite is a layered silicate with good friction-reduction and self-repairing properties.
Catalytic synthesis of functionalized (polar and non-polar) polyolefin block copolymers
Authors: Walsh Dylan J. , Su Eric , Guironnet Damien
Published: May 2018

Herein, we report a methodology for the synthesis of polyolefin containing block-copolymers using a catalytic postpolymerization modification strategy.
Rationally designed upconversion nanoprobe for simultaneous highly sensitive ratiometric detection of fluoride ions and fluorosis theranostics
Authors: Liu Yuxin , Jiang Anqi , Jia Qi , Zhai Xuejiao , Liu Lidong , Ma Liyi , Zhou Jing
Published: May 2018

We explore the feasibility of a novel pyrogallic acid–titanium(iv) complex-modified upconversion nanoprobe (UCNP–PA–Ti) for F− capture and real-time quantification.
Formation of a new type of uranium(iv) poly-oxo cluster {U38} based on a controlled release of water via esterification reaction
Authors: Martin Nicolas P. , Volkringer Christophe , Henry Natacha , Trivelli Xavier , Stoclet Grégory , Ikeda-Ohno Atsushi , Loiseau Thierry
Published: May 2018

A strategy for the formation of uranium(iv) clusters consists of water release from esterification reaction to generate {U38} species.
Evaluation of multiple cation/anion perovskite solar cells through life cycle assessment
Authors: Alberola-Borràs Jaume-Adrià , Vidal Rosario , Mora-Seró Iván
Published: May 2018

Herein, the environmental performance of the production of multiplication/anion and canonical perovskites was evaluated via life cycle assessment.
Size-dependent penetrant diffusion in polymer glasses
Authors: Meng Dong , Zhang Kai , Kumar Sanat K.
Published: May 2018

The universal scaling behavior of the diffusion coefficients D/T as a function of the “effective” penetrant size (σs − σc)/(α − α0).
The influence of air and temperature on the performance of PBDB-T and P3HT in organic thin film transistors
Authors: Brixi Samantha , Melville Owen A. , Boileau Nicholas T. , Lessard Benoît H.
Published: May 2018

We produced the first reported examples of OTFTs using PBDB-T, a conjugated push–pull polymer used in high performance OPVs, and assessed their performance compared to P3HT under different environmental conditions.
Efficient and stable mixed perovskite solar cells using P3HT as a hole transporting layer
Authors: Zhou Peng , Bu Tongle , Shi Shengwei , Li Lingfeng , Zhang Yulong , Ku Zhiliang , Peng Yong , Zhong Jie , Cheng Yi-Bing , Huang Fuzhi
Published: May 2018

Dopant-free P3HT was employed as hole transport materials for stable mixed perovskite planar solar cells.
High-performance WO3−x-WSe2/SiO2/n-Si heterojunction near-infrared photodetector via a homo-doping strategy
Authors: Guo Tianchao , Ling Cuicui , Zhang Teng , Li Hui , Li Xiaofang , Chang Xiao , Zhu Lei , Zhao Lin , Xue Qingzhong
Published: May 2018

The enhanced performance of WO3−x-WSe2/SiO2/n-Si can be mainly attributed to the down-shift of the EF of WO3−x-WSe2, which results in a larger interface barrier height and a greatly reduced dark current.
Cancer stem cells (CSCs): metabolic strategies for their identification and eradication
Authors: De Francesco Ernestina M. , Sotgia Federica , Lisanti Michael P.
Published: May 2018

Phenotypic and functional heterogeneity is one of the most relevant features of cancer cells within different tumor types and is responsible for treatment failure. Cancer stem cells (CSCs) are a population of cells with stem cell-like properties that are considered to be the root cause of tumor heterogeneity, because of their ability to generate the full repertoire of cancer cell types. Moreover, CSCs have been invoked as the main drivers of metastatic dissemination and therapeutic resistance. As such, targeting CSCs may be a useful strategy to improve the effectiveness of classical anticancer therapies. Recently, metabolism has been considered as a relevant player in CSC biology, and indeed, oncogenic alterations trigger the metabolite-driven dissemination of CSCs. More interestingly, the action of metabolic pathways in CSC maintenance might not be merely a consequence of genomic alterations. Indeed, certain metabotypic phenotypes may play a causative role in maintaining the stem traits, acting as an orchestrator of stemness. Here, we review the current studies on the metabolic features of CSCs, focusing on the biochemical energy pathways involved in CSC maintenance and propagation. We provide a detailed overview of the plastic metabolic behavior of CSCs in response to microenvironment changes, genetic aberrations, and pharmacological stressors. In addition, we describe the potential of comprehensive metabolic approaches to identify and selectively eradicate CSCs, together with the possibility to ‘force’ CSCs within certain metabolic dependences, in order to effectively target such metabolic biochemical inflexibilities. Finally, we focus on targeting mitochondria to halt CSC dissemination and effectively eradicate cancer.