bluuebunny/crossref_metadata_2025 huggingface dataset:
Childhood Cancer in an LMIC: Navigating the Wilderness
Authors: Joseph A. , Zubair A. , Opara C.
Published: September 2018

Background and context: When a child has cancer, the entire family is affected. Parents and caregivers lose work days while caring for the child. Many parents blame themselves and wonder if some action or decision of theirs contributed to; or caused the cancer. In addition, and especially for families falling within the low socioeconomic demographic groups, there may be poor understanding of the treatment process and expectations from treatment. Aim: To assess the most common challenges or concerns faced by parents, family members, or caregivers of a child living with cancer in Nigeria. Strategy/Tactics: A series of 10 focus group sessions were held with different groups of parents, family members, or other caregivers of children being treated for cancer at 2 teaching hospitals in Nigeria. Groups consisted of a minimum 8, and maximum of 12 participants in addition to a moderator. At the beginning of every session, participants were asked to submit 2 most pressing questions. Open-ended questions were also used with every attendee given a turn to give their answer. Participants were also given a chance to ask questions or bring up issues they had difficulty with. The single most prevalent concern raised in every focus group was lack of information or understanding. The 2 most common questions were: 1. What is cancer? 2. Why does my child have cancer? Program/Policy process: Data from the sessions were painstakingly compiled. The questions and concerns the attendee raised; and the degree of understanding they had regarding the diagnosis, treatment process, and expectations bring and after treatment. This data were collated and a team of experts including oncologists, nurses, and health workers in cancer were brought together to answer the questions. A compilation was made and a plan to disseminate the information was formulated. This culminated in the publishing of a free childhood cancer handbook; the first of its kind in Nigeria; with plans to translate the handbook into the common colloquial and vernacular languages in Nigeria. Outcomes: Participants of the focus groups were given a handbook, including some whose child had passed on since the sessions were held. 29% of the original participants were unreachable or declined the handbook. They were assessed to see if the handbook provided information that could have eased their cancer journey. 91% of assessed participants responded that having the handbook at diagnosis would have significantly increased their level of information and made the cancer journey easier. [Figure: see text][Figure: see text] The most appreciated information in the handbook was contact details of an organization dedicated to supporting them financially to pay treatment fees. What was learned: Many Nigerian families go through the entire childhood cancer journey completely in the dark. No dedicated information source on child cancer exists in Nigeria. Many parent and caregiver questions remain unanswered, and concerns remain unresolved.[Figure: see text]
From Diagnosis to Survivorship: Using Cancer Support Group as an Advocacy and Support Platform for Cancer Care in Nigeria
Authors: Orji M.-G. , Chidebe R.C.W. , Igbokwe C. , Banwo-Fatai K. , Adesoye B.S. , Gimba S. , Agbi R. , Nwosu T.O. , Ikeagwu N.C. , Onyekachi C. , Ademola A. , Amadi-Obi U. , Ezenwaanne J.N. , Ikechukwu I. , Yahaya O. , Ononogbu F. , Okenwa V. , Nwodilae G. , Biose A. , Nwabueze O. , Dada R. , Gimba R. , Adamu E. , Joseph F. , Onwere C. , Alimi I.M. , Oriaku I. , Emezue P. , Dantsoho S.A. , Nwagboso E.J. , Abdulazeez J. , Okoro N. , Orjiakor T.C.
Published: September 2018

Background and context: Cancer diagnosis comes with a lot of challenges. It is a huge burden to the patient, family, and community; subjecting them to financial crisis, emotional distress, dearth of self-esteem, and physiologic deformations. From a patient's perspective, treatment of cancer is complex and complicated with the weak healthcare system, attitude of healthcare workers, lack of insurance, lack of trust to orthodox medicine and stigmatization. Cancer patients are constantly seeking solace, people to listen to them and people who understand their state of mind and can be a source of inspiration. Studies have shown that peer cancer support group results in psychological benefit and improve relationships. The 2016 World Cancer Congress patient's pavilion inspired us to start up a cancer support group for cancer patients, survivors and caregivers known as Abuja Breast Cancer Support Group (ABC-SG). The cancer support was primarily founded for only breast cancer patient, survivor, caregivers and for peer support; as at today the group has transited from being patient group to also being an advocacy group with a number of activities and programs aimed at propelling all cancer patients from diagnosis to survivorship. Aim: To disseminate impact of establishing a breast cancer support group in Abuja and how it has helped cancer patients/survivors inspire each other while engaging policymakers to make cancer control a national health priority in Nigeria. Strategy/Tactics: The study reviewed the 1-year activities of the ABC-SG and surveyed the impact of the peer support to the 36 members of the group. Program/Policy process: As part of Project PINK BLUE SPARC MBC activities, ABC-SG was supported in different activities and programs targeted at peer support and policy change advocacy. Outcomes: The cancer support group have become a point of networking and inspiration for several patients and survivors; hence, more cancer patients are beginning to come out from their closest to identify with the support and make their diagnosis public. What was learned: There is an improvement in psychological states of patients and their physiologic understanding of their diagnosis by meeting together, networking, and interaction through social media. Our qualitative finding also showed that cancer patients needs platforms to speak out, to advocate and to change the course of cancer care if provided with all the necessary training and support.
The Externalities of Advocacy: The High Cost of Standing Up for Patients' Dignity in Senegal
Authors: Ndiaye S. , Moreira C. , Ndiaye S.M.
Published: September 2018

Background and context: In Senegal, pediatric oncology patients arrive at the hospital at advanced stages of disease. Their large tumors, as well as the side effects of chemotherapy make children experience intense pain. In this low-resource setting, morphine supply was quite irregular. Doctors don´t prescribe morphine due to shortages; but few prescriptions also lead to limited orders. A vicious circle with only 1 victim: the patient. Hearing children in pain was agonizing for everyone: patients, caregivers and healthcare practitioners. Aim: This advocacy narrative illustrates how the fight for access to morphine in pediatric oncology has led to both positive and negative externalities. We will highlight ways in which this fight for morphine has provoked political tensions moving the issue forward, but has also affected the careers of health workers involved. Strategy/Tactics: Morphine is a cheap drug, yet it is extremely regulated by international laws. It takes political will to influence national morphine orders. This advocacy strategy was built on raising awareness and setting morphine shortage on the political agenda. Not providing morphine in oncology goes against international standards of care. But most importantly, letting patients suffer without “existing” relief is a breach of basic human right to live - and also die - in dignity. Program/Policy process: Conversations began within the pediatric oncology department. Focus groups highlighted caregivers' feelings of powerlessness before their suffering child. Interviews with key informants (doctor and nurses) were instrumental to a widely diffused Human Rights Watch report exploring the medical and political causes to morphine supply shortages, as well as its psychological repercussions on patient care. A BBC documentary was broadcasted soon after. Subsequently, meetings were held between the Ministry of Health, the National Supply Pharmacy and leading local oncologists. Outcomes: Morphine orders were multiplied by 10, leading to much improved pain management for patients. However, Senegal was portrayed negatively on the international scenes, much to the Health Minister´s dismay. The consequences were incurred by the health workers who contributed to the international publications/reports. What was learned: Health practices can inform policy just like policy can inform health practices. It is a cyclical process. Creating advocacy coalitions and rallying the help of the international community are effective strategies. However, in the political arena, health workers need more than commitment to human rights and quality care. Even in democratic republics, systems can penalise outspoken activists. We have learned that health care practitioners (especially working in public settings) who wish improvement for their patients must learn to be tactical and diplomatic. International partners will return to their home countries, but local actors will pay the high cost of advocacy.
The Current Status of Cancer Control in China
Authors: Wang Y.
Published: September 2018

Background and context: With the rapid economic growth and aging population, China is now facing the challenge of cancer burden. China National Cancer Registry data displayed that >4 million people were diagnosed with cancer in 2012, which accounted for 20% of global cancer incidence and 25% global cancer deaths occurred in China. Lung, gastrointestinal, breast cancers are the top 3 most common caused cancer diseases for Chinese people. Cancer brings huge economic loss both to Chinese economy and individuals. The total cancer cost has been raised 4 times more than in 2003, which was estimated to >400 billion Chinese Yuan. From 1970s, Chinese government attached importance to cancer control and conducted cancer prevention and control planning and strategy, but the medical resource allocation for cancer is still inequality in the country. Aim: China Anti-Cancer Association (CACA) investigates a research on how cancer control medical resource allocates in China and provides suggestion on cancer control policy development. Strategy/Tactics: Through collecting the data from 55 cancer hospitals across the country from 2013 to 2015 to analyze. Program/Policy process: The results show that oncology doctors and nurses slightly increase in consecutive 3 years, but the outpatient and inpatient visits grow in the average annual rate of 10%, the oncology professionals supply falls short of patient's demand. In terms of geography distribution, the cancer control medical resources are rich in municipality, capital cities and coastline cities. Northeast, southwest, and northwest part of China have weak medical resources to prevent and cure cancers. The oncology professional is constituted by clinical surgery, internal medical doctor, radiation therapist, and others. Clinical surgery is estimated to account for 40% of all professionals in cancer hospitals. The oncology professionals have higher education and academic background in third-grade class A hospitals. Inpatient and outpatient visits are much more in provincial cancer hospitals, rather than in prefectural-level cancer hospitals. Outcomes: Based on the research, CACA suggests that government should realize the importance of cancer control medical resource allocation, including increasing the number of oncology professionals, strengthening the professionals' academic training in secondary class A hospitals and prefectural-level cancer hospitals, and providing more financial investment to the parts where have insufficient medical resources. In addition, CACA advocates to taking the actions on tobacco control, HPV and HBV vaccine injection, changing healthy lifestyle, implementing the strategy of early detection, diagnose, and treatment, and formulating standardized and precision cancer treatment guideline, to ease the cancer burden so as to improve people's healthy life in China.
Bending the Cost Curve of Cancer Care Awareness and Campaigns Through Volunteers
Authors: Chidebe R.C.W. , Orjiakor T.C. , Okoro N. , Dantsoho S.A. , Nwagboso E.J. , Abdulazeez J. , Emezue P. , Ogugua T.E. , Lyonga N. , Gata Z.D. , Okonkwo R.
Published: September 2018

Background and context: Nigeria has been rated the 1st nation in Africa and 5th in the world with highest cervical cancer deaths with >26 women dying daily. Breast cancer incidence is higher with 90 new cases per 100,000 women annually in some western countries, compared with 30 per 100,000 in some African countries. In contrast, breast cancer deaths are almost identical, at about 15 per 100,000, which clearly points that late diagnosis and much poorer survival in Africa. Late diagnosis of cancer is possibly encouraged due to low awareness and sporadic screenings across Nigeria. To mitigate this system-wide gap, huge resources are required from the government, corporate organizations and nonprofits engaged in cancer awareness and programs. For a nonprofit with limited resources, volunteers became the most significant resource to create the needed policy change, public awareness and fundraising for cancer patients. In 2013, Project PINK BLUE started as a personal community development service of the National Youth Service Corp (NYSC) in Nigeria with as little as 5 volunteers whom organized the first community awareness program that mobilized 168 women in Kabusa community in Abuja. By 2018, Project PINK BLUE has 501 volunteers across Nigeria and Cameroon. With impact awareness events engaging thousands of people and raising supports for cancer patients while advocating for policy change. Aim: To share how the use volunteers has propelled the nonprofit organization to reach millions in <5 years while spending less on human resource compared with her impact. Strategy/Tactics: Project PINK BLUE designed a volunteer program that provides young people the platform to learn, network, grow and cultivate opportunities for themselves. The organization engage volunteers base on projects and activities all year round. Program/Policy process: The program's policy for volunteers is strictly on nonpayment; several young people have used the volunteer program to gain employment opportunities, meet amazing friends, achieve their dream and most importantly touch lives. Outcomes: Our statistics showed that we have 277 volunteers with Bachelors of Science, 63 with Masters degree, 20 in high school, 14 with higher national diploma, 13 with OND and 114 others. 40% of the volunteers have basic knowledge of cancer, 45.7% intermediate and 14.3% advanced knowledge. 87% of the volunteers responded to be available for cancer awareness activities, 10.9% were undecided and <2% responded no. What was learned: Qualitative responses showed that the volunteers needed to be more engaged in series of cancer activities.
Growth control through regulation of insulin-signaling by nutrition-activated steroid hormone in Drosophila
Authors: Buhler Kurt , Clements Jason , Winant Mattias , Bolckmans Lenz , Vulsteke Veerle , Callaerts Patrick
Published: September 2018

Growth and maturation are coordinated processes in all animals. Integration of internal cues, such as signalling pathways, with external cues such as nutritional status is paramount for an orderly progression of development in function of growth. In Drosophila, this involves insulin and steroid signalling, but the underlying mechanisms and their coordination are incompletely understood. We show that bioactive 20-hydroxyecdysone production by the enzyme Shade in the fat body is a nutrient-dependent process. We demonstrate that under fed conditions, Shade plays a role in growth control. We identify the trachea and the insulin-producing cells in the brain as direct targets through which 20-hydroxyecdysone regulates insulin-signaling. The identification of the trachea-dependent regulation of insulin-signaling exposes an important variable that may have been overlooked in other studies focusing on insulin-signaling in Drosophila. Our findings provide a potentially conserved, novel mechanism by which nutrition can modulate steroid hormone bioactivation, reveal an important caveat of a commonly used transgenic tool to study IPC function and yield further insights as to how steroid and insulin signalling are coordinated during development to regulate growth and developmental timing.
Nuclear envelope localization of PIG-B is essential for GPI-anchor synthesis in Drosophila
Authors: Yamamoto-Hino Miki , Katsumata Eri , Suzuki Emiko , Maeda Yusuke , Kinoshita Taroh , Goto Satoshi
Published: September 2018

Membrane lipid biosynthesis is a complex process that takes place in various intracellular compartments. Glycosylphosphatidylinositol (GPI), a lipid involved in membrane anchoring of some proteins, is synthesized by the PIG enzymes. Most PIGs are localized to the endoplasmic reticulum (ER), but Drosophila PIG-B (DmPIG-B) is localized to the nuclear envelope (NE). To determine whether the NE localization of DmPIG-B is functionally important, we defined the determinants of localization and generated an ER-localized form, denoted DmPIG-B[ER]. The enzymatic activity of DmPIG-B[ER] was comparable to that of NE-localized DmPIG-B[NE]. Expression of DmPIG-B[ER] inefficiently rescued the lethality of the PIG-B mutant, whereas DmPIG-B[NE] rescued this lethality fully. DmPIG-B[ER] was preferentially degraded by lysosomes, suggesting that the NE localization is essential for function and stability of the protein. In addition, we found that the region of the ER proximal to the NE is the site of translation of GPI-anchored proteins and addition of GPI. Thus, the NE and proximal ER may provide a platform for efficient GPI anchoring.
Evidence of embryonic regulation of maternally derived yolk corticosterone
Authors: Carter A. W. , Bowden R. M. , Paitz R. T.
Published: September 2018

In recent years, the potential for maternal stress effects to adaptively alter offspring phenotype has received considerable attention. This research has identified offspring traits that are labile in response to maternal stress; however, an understanding of the mechanisms underlying these effects is lagging and is crucial to appreciating the significance of this maternal effect. In the present study, we sought to better understand maternal stress effects by examining the potential for embryonic regulation of corticosterone exposure, determining the phenotypic consequences of elevated corticosterone during development, and characterizing the levels of maternally transferred corticosterone in unmanipulated eggs using Trachemys scripta. By dosing eggs with tritiated corticosterone and tracking the steroid throughout development, we found that most corticosterone is metabolized, and less than 1% of the corticosterone dose reaches the embryo as free corticosterone. We also found that exogenous dosing of corticosterone, in concentrations sufficient to overwhelm embryonic metabolism, reduces embryonic survival and negatively impacts hatchlings traits important to fitness. Lastly, we demonstrate that concentrations of maternal corticosterone in the yolks of unmanipulated eggs are low and are significantly lower than the doses of corticosterone required to elicit phenotypic effects in hatchlings. Taken together, these results provide evidence that both the embryo and the female may minimize corticosterone accumulation in the embryo to avoid reductions in embryonic survival and negative impacts on offspring phenotype and fitness.
Global/Local Chirality and Global/Local RS-Stereogenicity for Characterizing [2.2]Paracyclophane Derivatives as Stereogenic Planes
Authors: Fujita Shinsaku
Published: September 2018

The conceptual difference between RS-stereoisomerism and stereoisomerism as well as between RS-stereogenicity and stereogenicity is discussed according to Fujita’s stereoisogram approach (S. Fujita, Mathematical Stereochemistry; De Gruyter: Berlin, 2015). Enumeration of [2.2]paracyclophanes is conducted to clarify hierarchy of stereoisomerism, i.e., under the point group D2 (individual derivatives), the point group D2h (enantiomerism), the RS-stereoisomeric group $\boldsymbol{{D}}_{\textbf{2}\boldsymbol{{h}}\tilde{\boldsymbol{{\sigma}}}\skew2\hat{\boldsymbol{{I}}}}$ (RS-stereoisomerism), the stereoisomeric group $\boldsymbol{{sD}}_{\textbf{2}\boldsymbol{{h}}\tilde{\boldsymbol{{\sigma}}}\skew2\hat{\boldsymbol{{I}}}}$ (stereoisomerism). Stereoisograms for characterizing RS-stereoisomerism are discussed briefly for the purpose of examining nomenclature of [2.2]paracyclophane derivatives. Global and local RS-stereogenicities as well as global and local RS-stereoisomerism are discussed on the basis of two kinds of handedness. Nomenclature for global RS-stereogenicity and that for local RS-stereogenicity are discussed after two modes of numbering of skeletal carbons are determined explicitly.
Results supporting the concept of the oxidant-mediated protein amino acid conversion, a naturally occurring protein engineering process, in human cells
Authors: Suzuki Yuichiro J. , Hao Jian-Jiang
Published: September 2018

Reactive oxygen species (ROS) play an important role in the development of various pathological conditions as well as aging. ROS oxidize DNA, proteins, lipids, and small molecules. Carbonylation is one mode of protein oxidation that occurs in response to the iron-catalyzed, hydrogen peroxide-dependent oxidation of amino acid side chains. Although carbonylated proteins are generally believed to be eliminated through degradation, we previously discovered the protein de-carbonylation mechanism, in which the formed carbonyl groups are chemically eliminated without proteins being degraded. Major amino acid residues that are susceptible to carbonylation include proline and arginine, both of which are oxidized to become glutamyl semialdehyde, which contains a carbonyl group. The further oxidation of glutamyl semialdehyde produces glutamic acid. Thus, we hypothesize that through the ROS-mediated formation of glutamyl semialdehyde, the proline, arginine, and glutamic acid residues within the protein structure can be converted to each other. Mass spectrometry provided results supporting that proline 45 (a well-conserved residue within the catalytic sequence) of the peroxiredoxin 6 molecule may be converted into glutamic acid in cultured human cells, opening up a revolutionizing concept that biological oxidation elicits the naturally occurring protein engineering process.
Recent advances in the management of anal cancer
Authors: Symer Matthew M. , Yeo Heather L.
Published: September 2018

Anal cancer is a rare condition, although its incidence has been increasing over the past several decades, particularly in women. The majority of anal cancers are squamous cell cancers and are linked with human papilloma virus (HPV) infection. Recent work in HPV basic science has delineated the mechanism by which the virus leads to the development of anal cancer. With widespread availability of an HPV vaccine since 2006, vaccination has become an important strategy for anal cancer prevention. However, in the US, there remain no guidelines for anal cancer screening. Treatment of anal cancer is dictated largely by accurate staging, which is generally accomplished with a combination of physical exam, magnetic resonance imaging, computed tomography, and positron emission tomography. Chemoradiation remains the mainstay of treatment for most patients, with surgery reserved for salvage therapy. Recent trials have identified the optimal use of available chemotherapeutics. Exciting developments in immune therapies targeting HPV oncoproteins as well as therapeutic vaccines may soon dramatically change the way patients with anal cancer are managed.
New biological and genetic classification and therapeutically relevant categories in childhood B-cell precursor acute lymphoblastic leukemia
Authors: Starý Jan , Zuna Jan , Zaliova Marketa
Published: September 2018

Traditionally, genetic abnormalities detected by conventional karyotyping, fluorescencein situhybridization, and polymerase chain reaction divided childhood B-cell precursor acute lymphoblastic leukemia (BCP-ALL) into well-established genetic subtypes. This genetic classification has been prognostically relevant and thus used for the risk stratification of therapy. Recently, the introduction of genome-wide approaches, including massive parallel sequencing methods (whole-genome, -exome, and -transcriptome sequencing), enabled extensive genomic studies which, together with gene expression profiling, largely expanded our understanding of leukemia pathogenesis and its heterogeneity. Novel BCP-ALL subtypes have been described. Exact identification of recurrent genetic alterations and their combinations facilitates more precise risk stratification of patients. Discovery of targetable lesions in subsets of patients enables the introduction of new treatment modalities into clinical practice and stimulates the transfer of modern methods from research laboratories to routine practice.
Levantamento, classificação e categorização dos indicadores da atividade de PD&E
Authors: Borschiver Suzana
Published: September 2018

As empresas vêm aprimorando seu processo de PD&E[1] industrial quando já existente e implantando novos, no caso de não existente, conscientes da sua necessidade e importância para o alcance de uma competividade sustentável. Um dos problemas relacionados a essa gestão é a avaliação da eficiência e eficácia do processo de PD&E e seu acompanhamento, através de indicadores que traduzam não somente a aderência dos projetos à estratégia da empresa como também à administração de portifólio desses projetos e dos resultados obtidos a partir de recursos normalmente escassos. O presente artigo tem por objetivo fazer um levantamento, classificação e categorização dos indicadores da atividade de PD&E industrial relacionados na literatura e utilizados em empresas relacionadas com o setor industrial. [1] PD&E de acordo com definição da ANPEI é pesquisa, desenvolvimento e engenharia não rotineira.
Indicadores de sustentabilidade empresarial e gestão estratégica
Authors: Coutinho Anderson Américo Alves , Barata Martha Macedo de Lima , La Rovere Emílio Lèbre
Published: September 2018

A partir da constatação de que as empresas, para serem sustentáveis, necessitam gerenciar também as variáveis ambiental, social, de saúde e de segurança do trabalhador, os autores propõem critérios para definir, implementar e relatar indicadores que possibilitem, aos gestores de empresa, avaliarem seu desempenho nas mencionadas variáveis, ao longo do tempo e em comparação com outras empresas. A metodologia utilizada baseou-se em levantamento de informações, avaliação bibliográfica e consolidação da experiência acumulada em estudo de caso de empresa do setor de petróleo. Em análise dos relatórios de sustentabilidade atualmente publicados por empresas do setor de petróleo os autores detectaram que estas usam indicadores que denotam uma atitude reativa das mesmas, o que dificulta sua mudança de postura e, portanto a sua efetiva sustentabilidade.
Mineração de Dados com Mapas de Kohonen: uma Abordagem no Setor Financeiro
Authors: Pinho Anderson Guimarães de
Published: September 2018

Clientes que decidem porinvestir em ações na Bolsa de Valores de São Paulo (Bovespa) podem optar por ações de empresas nosmais diversos ramos de atividade. Se gestores do marketing souberem explicitar o conhecimentonecessário para diferenciar clientes de acordo com o setor em que operam na bolsa de valores, estespoderão incorporar este conhecimento nos processos da empresa, maximizando lucros e resultados.Mapas de Kohonen representam uma classe de modelos de redes neurais denominados mapas autoorganizáveise seu potencial de aplicação em processos de descoberta de conhecimento representaalguma vantagem competitiva. Em nosso caso de aplicação isto significa separar clientes de acordocom suas concentrações de operações na Bovespa nos 10 possíveis mercados de ações. Os resultadosmostrarão que clientes podem ser agrupados em 1 de 6 clusters diferentes, cada um comcaracterísticas bastante singulares.
Modelo Estratégico de Materiais na área de Telecomunicações em uma Empresa do Setor Petrolífero
Authors: Ferreira Ailton Da Silva , Oliveira Denise Cristina de , Silva Geanni Barbosa de Silveira e , Barreto Suelem Ribeiro , Ornellas Alander
Published: September 2018

A empresa colocada como objeto de estudo nesse trabalho de conclusão de curso, juntamente comoutras empresas da indústria petrolífera, estão mudando seus olhares em relação à logística e administração demateriais, devido ao seu papel fundamental na integração da cadeia de suprimentos de uma empresa. Destarte,assegurando a manutenção de uma base de dados adequada e confiável, contribuindo para a integração entre osórgãos envolvidos e destes seus diversos usuários, através de um tratamento adequado e homogêneo dos dados,com confiabilidade e presteza; além de assegurar um nível mínimo de suprimento compatível com o necessáriopara a atividade, evitando principalmente, o risco da falta de material de contingência.O outro ponto positivo quepodemos citar foi a adesão do organograma proposto para o processo de gestão de materiais, além dodesenvolvimento de treinamento aos colaboradores envolvidos no processo
Fidelização e Co-criação de Valor: uma Visão integrada
Authors: Troccoli Irene Raguenet
Published: September 2018

este artigo visa a entender a proposta lançada por Prahalad & Ramaswamy(2004), de co-criação do valor dos produtos e serviços a partir de uma parceria entreofertantes e seus clientes, enquanto elemento relevante na construção da fidelização destesúltimos.Para atingir este propósito, dividiu-se o artigo em cinco partes: 1) definição de fidelização e ajustificativa para seu estudo; 2) apresentação dos guidelines da pesquisa acadêmica deMarketing voltada para a retenção dos clientes, realizada ao longo do século XX; 3)apresentação da abordagem à criação de valor proposta por Prahalad & Ramaswamy (2004);4) interação desta abordagem ao modelo de fidelização proposto por Oliver (1999); 5)conclusão da análise, e sugestão de novos desenvolvimentos.
O USO DO YOUTUBE COMO FERRAMENTA DE MARKETING: O CASO GUARANÁ ANTARCTICA
Authors: Pereira Thiago Carvalho , Cruz Eduardo Picanço
Published: September 2018

Este trabalho tem como objetivo estudar como o site YouTube tem sido utilizado pelas grandes empresas como uma eficiente ferramenta de promoção de marketing. Para isso, será utilizado como estudo de caso a marca Guaraná Antarctica e seu espaço no YouTube, bem como a difusão desta através dos usuários pela comunicação viral. Para tanto, o artigo manterá o foco no composto de marketing. É realizada uma abordagem sobre mídia expondo os principais meios de comunicação e suas características, e as tendências do uso da mídia nos próximos anos. Em seguida apresentamos o YouTube, sua história, funcionalidade, repercussão e sobre as ações de marketing realizadas no mesmo. Por fim, será exposto o estudo de caso propriamente dito, que abordará a história e o marketing do Guaraná Antarctica, sua relação com o YouTube e os resultados do trabalho.
VENDERAM MEU FUTURO: CRISE E A NOVA GERAÇÃO
Authors: Motta Paulo Cesar , Gomes Monica Zaidan , Valente Paula
Published: September 2018

Este trabalho conjectura uma geração nascente no Brasil em meio a um cenário de turbulência econômica, decorrente particularmente da crise dos Estados Unidos. O método compõe-se de dois estudos distintos. O primeiro estudo explora a validade das memórias coletivas brasileiras em relação a eventos históricos, através de um levantamento efetuado em amostra de 572 respondentes. O segundo levanta possíveis experiências negativas relacionadas à crise, tendo por base valores obtidos de fontes bibliográficas. Nos resultados, foram identificadas 14 principais experiências negativas, classificadas em quatro grupos: Aversão Ao Risco, Proteção Governamental, Restrição de Consumo e Senso de Propósito. O trabalho conclui com proposições sobre o estilo de vida e consumo familiar, tais como valorização do consumo coletivo, substituição do prazer material pelo de maior contato humano, recuperação da cultura do “ser” em detrimento da cultura do “ter” e práticas empresariais éticas, a fim de obter reciprocidade no mercado.
PLANO DE VIDA: PROPOSTA DE UM PROGRAMA DE PREPARAÇÃO PARA A REFORMA
Authors: Mainardes Emerson Wagner , Martins Oliva , Silva Maria José
Published: September 2018

Nos momentos mais difíceis, as pessoas, de uma forma geral, sentem a falta de um planeamento da sua vida pessoal e profissional. O objectivo deste estudo foi propor um “plano de vida” ou um “guia de planeamento pessoal”, baseado nos tradicionais modelos de “planos de negócios”, que vise uma reforma tranquila. No final deste estudo, pretendeu-se fornecer uma estrutura de modelo que permita o desenvolvimento de um guia prático para a construção de planeamento pessoal ao longo da vida do indivíduo, bem como oferecer uma estrutura básica para o desenvolvimento de softwares que facilitem a construção deste planeamento da vida das pessoas, pois acredita-se que uma vida planeada oferece melhores condições para ter-se uma vida com mais qualidade, antes e depois da reforma.
EVOLUÇÃO DO BALANÇO SOCIAL NA ADMINISTRAÇÃO PÚBLICA ITALIANA
Authors: Criscuolo Vincenzo
Published: September 2018

O paper analisa em termos comparativos as regras de redação do balanço social pelas administrações públicas (APs), propondo e estabelecendo os dois principais padrões já existentes na Itália: o Grupo de Estudo sobre o Balanço Social (GBS), que, em 2005, produziu um standard aplicável para todas as APs, e o Observatório das Finanças e Contabilidade das Entidades Locais, que publicou, em 2007, as diretrizes chamadas na Itália “Linhas Guia” para os relatórios sociais nas entidades locais. A comparação evidencia uma ampla área comum, mas também algumas diferenças significativas. A segunda parte do trabalho oferece algumas evidências empíricas, em particular o documento que foca a realidade de uma província italiana específica. A combinação entre as análises dos conteúdos dos standards e as evidências empíricas evidencia algumas áreas críticas para os relatórios sociais no contexto das APs italianas, para as quais deve-se endereçar os futuros aprofundamentos teóricos e as experimentações operacionais.
DIFERENTES COMPORTAMENTOS DOS USUÁRIOS DE PRODUTOS FINANCEIROS PELA INTERNET: UM ESTUDO EXPLORATÓRIO
Authors: Toda Favio Akiyoshi , Levrini Gabriel R. D. R.D.
Published: September 2018

O presente estudo tem for finalidade ampliar o entendimento do comportamento dos usuários de produtos financeiros via internet, sob uma perspectiva de Finanças Comportamentais visto que as decisões dos clientes nem sempre seguem uma decisão baseado somente em uma lógica racionalista. Os resultados indicam que mesmo estando em um mesmo espaço do ambiente virtual do banco, as atitudes sobre a utilização dos produtos e serviços ofertados aos clientes divergem em função dos níveis de envolvimento que possuem para cada um dos serviços e produtos. Este trabalho foi construído com base no estudo desenvolvido por Lian e Lin (2008) de onde se adaptou para a realidade brasileira o modelo de medidas adotado pelos autores, e também serviu como orientação metodológica.
UTILIZAÇÃO DA LÓGICA PARACONSISTENTE EM PROCESSOS DE TOMADA DE DECISÃO: UM CASO PRÁTICO
Authors: Sanches Cida , Meireles Manuel , Marietto Marcio , Silva Orlando , De Sordi José Osvaldo
Published: September 2018

A pesquisa abordou o processo de tomada de decisão de gestores utilizando-se de algoritmo para-analisador baseado em lógicas não-clássicas: a lógica paraconsistente anotada (LPA). O método é apropriado ao tratamento de dados incertos, contraditórios ou paracompletos; consiste em estabelecer proposições e parametrizá-las para isolar os fatores de maior influência nas decisões. Especialistas são utilizados para obtenção de anotações sobre esses fatores, atribuindo-lhes graus de crença e descrença. No caso analisado, utilizou-se da LPA como instrumento de apoio ao processo de avaliação e seleção de profissional a ser promovido a gerente, dentre cinco possíveis, em pequena empresa familiar. Os três sócios-gerentes da empresa constituíram o grupo de especialistas, na medida em que conhecem o valor profissional dos cinco funcionários. A interpretação das avaliações realizadas pelos especialistas deu-se por intermédio dos baricentros no quadrado unitário do plano cartesiano (QUPC), que indicou os graus de inconsistência ou de indeterminação dos dados utilizados.
FLOWER BALL. The scenario of interactive event-holiday
Authors: Жукова Ирина , Zhukova Irina
Published: September 2018

The author offers a method of holding an interactive holiday, which brings together poems, a variety of myths, legends, legends of different peoples about the colors, stories about the use of the theme of colors in art. The objectives of the event are to update students 'knowledge about the role of flowering plants in nature and human life; formation of students' awareness of their relationship with nature and personal responsibility for its condition; development of ethics of relations with nature; key information competencies. During the event, an interactive method is used: a significant part of the information students are invited to extract on their own using the Internet
Magnetospheric response of two types in PSc geomagnetic pulsations to interaction with interplanetary shock waves
Authors: Пархомов Владимир , Parhomov Vladimir , Бородкова Наталия , Borodkova Natalia , Яхнин Александр , Yahnin Aleksandr , Теро Райта , Tero Raita , Цэгмэд Б. , Tsegmed B. , Хомутов Сергей , Khomutov Sergey , Пашинин Александр , Pashinin Aleksandr , Чиликин Виталий , Chilikin Vitaliy , Мочалов Алексей , Mochalov Aleksey
Published: September 2018

Using the June 22, 2015 event as an example, we present new data confirming the presence of a precursor of the sudden magnetic impulse caused by a powerful interplanetary shock wave (ISW). The precursor in the form of a train of oscillations (broadband pulse) with a falling frequency in the range 0.25÷11 Hz with a duration of ~20 s, which had a spectral resonance structure, was recorded globally by a network of induction magnetometers at 18:33:27 UT. No significant phase delays of the signals were detected in four frequency bands at widely spaced observatories. It is suggested that the impulse can be excited in the Earth – ionosphere waveguide by a pulsed electric field which occurs in the ionosphere due to the short-term impact of ISW on the magnetosphere.
Real-time forecast of MUF for radio paths from current data obtained from oblique sounding with continuous chirp signal
Authors: Ильин Николай , Ilyin Nikolay , Бубнова Татьяна , Bubnova Tatyana , Грозов Виктор , Grozov Viktor , Пензин Максим , Penzin Maksim , Пономарчук Сергей , Ponomarchuk Sergey
Published: September 2018

We present a technique of MUF real-time forecast based on time extrapolation for maximum observed frequencies smoothed over a long-term forecast along a given path. We have validated the technique of fitting current data from the long-term forecast, using the OPEMI model, transmission curve method for short paths, and method of normal waves for long paths (over 2000 km). This technique has been tested using data obtained at the chirp sounding network of ISTP SB RAS during periods of strong and weak solar activity. The quality of the forecast has been found to significantly improve in comparison to the long-term forecast, with advance intervals of real-time forecast from 15 to 30 min. The sessions, in which the real-time forecast error is less than 10 % for 15-min advance interval, comprise from 67 to 96 % of all sessions depending on season and radio path orientation.
Heliolatitude regularities of magnetically disturbed days with daily average geomagnetic index Dst<–100 nT
Authors: Макаров Георгий , Makarov Georgy
Published: September 2018

This paper considers storm days for a period 1966–2015 when the daily average geomagnetic Dst index was <–100 nT. The distribution of the number of days with a high daily average Dst is shown to depend on Earth’s heliolatitude φ: the number of days increases with the absolute value of φ in both solar hemispheres. It is found, as expected, that the seasonal distribution of storm days with Dst<–100 nT has equinoctial maxima. Moreover, there is a noticeable increase in the number of such days in July and November. It is noted that at Earth’s heliolatitudes of 4.1°÷5.0° there is a sharp increase in the number of storm days. It is established that this increase occurs during storm events in July and November, which stand out against the seasonal distribution of highly disturbed days.
Ionospheric disturbances over East Asia during intense December magnetic storms of 2006 and 2015: similarities and differences
Authors: Золотухина Нина , Zolotukhina Nina , Куркин Владимир , Kurkin Vladimir , Полех Неля , Polekh Nelya
Published: September 2018

Using data from ionosondes, located in East Asia, and total electron content maps, we have made a comparative analysis of ionospheric disturbances as-sociated with the intense geomagnetic storms of De-cember 14–16, 2006 and December 19–22, 2015. These storms had almost equal peak intensities (Dstmin=–162 and –155 nT), but different durations of the main phases (2.5 and 19 hr). At the beginning of both the storms, the region under study was located in the vicinity of the midnight meridian. Ionospheric re-sponses to magnetic storms differed in: i) an increase in the F2-layer critical frequency at subauroral latitudes, caused by an increase in auroral precipitation, during the initial phase of the former storm and the absence of this effect in the latter; (ii) a sharp drop in the critical frequency in the evening hours of the main phase of the latter storm, caused by a shift of the main ionospheric trough to lower latitudes, and the absence of this effect during the former storm; (iii) generation of a short-term positive disturbance observed at subauroral latitudes only in the early recovery phase of the former storm after the negative ionospheric disturbance. During both the storms at middle latitudes there were positive dis-turbances and wave-like fluctuations of the critical fre-quency which increased in the vicinity of the dawn me-ridian. The main causes of the differences between the ionospheric storms are shown to be the differences be-tween the initial conditions of the magnetosphere-ionosphere system and durations of the main phases of magnetic storms.
Polarization dynamics of Pi2 pulsations at midlatitudes during development of substorms in the auroral zone
Authors: Рахматулин Равиль , Rakhmatulin Ravil , Пашинин Александр , Pashinin Aleksandr
Published: September 2018

We examine the changes in the orientation of the major axis of the polarization ellipse of irregular geomagnetic pulsations Pi2, observed at midlatitudes during a substorm disturbance developing in the auroral zone of the Russian Arctic sector. We have found the dependence of the polarization ellipse orientation on the longitude of a corresponding substorm. The results of current studies are compared with earlier results of similar studies using data on the North American continent. We have concluded that the results are similar in general, with a slight discrepancy which may be due to peculiarities of the geological structure of the earth crust in the Russian Arctic sector.
Adjacency-Clustering and Its Application for Yield Prediction in Integrated Circuit Manufacturing
Authors: Hochbaum Dorit S. , Liu Sheng
Published: September 2018

Accurate yield prediction in integrated circuit manufacturing enables accurate estimation of production cost and early detection of processing problems. It is known that defects tend to be clustered and a chip is likely to be defective if its neighbors are defective. This neighborhood effect is not well captured in traditional yield modeling approaches. We propose a new yield prediction model, called adjacency-clustering which addresses, for the first time, the neighborhood effect, and delivers prediction results that are significantly better than state-of-the-art methods.

Adjacency-clustering (AC) model is a form of the Markov random field minimum energy model (MRF) that is primarily known in the context of image segmentation. AC model is a novel use of MRF for identifying defect patterns that enable diagnosis of failure causes in the manufacturing process. In this paper we utilize the defect patterns obtained by the AC model for yield prediction. We compare the performance of the AC model to that of leading yield prediction models including the Poisson, the negative binomial, the Poisson regression, and negative binomial regression models, on real data sets and on simulated data sets. The results demonstrate that the adjacency-clustering model captures the neighborhood effect and delivers superior prediction accuracy. Moreover, the concept and methodology of adjacency-clustering are not limited to integrated circuit manufacturing. Rather, it is applicable in any context where a neighborhood effect is present, such as disease risk mapping and energy consumption prediction.

The e-companion is available at https://doi.org/10.1287/opre.2018.1741 .
Nipah Virus: An Outbreak of Deadly Paramyxvirus
Authors: Arora Ayushi , Dogra Anush , Dogra Ayush , Goyal Bhawna , Maulik Sharma Apoorav
Published: September 2018

The outbreak of the deadly virus namely nipah virus has been first discovered in Malaysia in 1988. The later outbreaks were recorded in Bangladesh and India. The natural host of this virus is found to be fruit bats. From the fruit bats the virus gets transferred to fruits and vegetables and animals also. Mainly pigs are the ones which easily get infected due to the virus. The fatality rate is very high due to this virus. No vaccine has been yet developed which can cure human infection. In this article the development of nipah virus from 1998 to 2018 is studied and current developments, preventive measures have been studied in order to prevent the future outbreaks.
Noise Issues Prevailing in Various Types of Medical Images
Authors: Goyal Bhawna , Dogra Ayush , Agrawal Sunil , Sohi B.S.
Published: September 2018

The current literature documents a plethora of image denoising techniques in the fields of medical imaging, remote sensing, biometrics, surveillance and vegetation mapping. Therefore it is important to have brief insight into various types of noises in different type of images, for instance medical images, remote sensing images and natural images. This article encompasses the basic definition, history, usage and type of noise affecting some of the major types of imaging modalities. Besides this a brief discussion on the type of noise prevailing in remote sensing and natural images is also given. While designing an effective image denoising algorithm, one needs to be acquainted with the prior information about the noise prevalent in various types of images. Further, a brief idea about the basic principle, outlook, contrast levels and application of medical imaging modalities has also been presented in the context of this article.­­­­­­