bluuebunny/crossref_metadata_2025 huggingface dataset:
Cilostazol Improves Hyperglycemia-Induced Impairment of Angiogenesis by Stimulating Adiponectin/Adiponectin Receptor1/Sirtuin1
Authors: Tseng Shih-Ya , Chang Hsien-Yuan , Li Yi-Heng , Chao Ting-Hsing
Published: November 2021

Background: Cilostazol is an antiplatelet agent with vasodilating effects that functions by increasing the intracellular concentration of cyclic adenosine monophosphate. However, the effect of cilostazol on adiponectin is still unclear. Purpose: We investigated the effects of cilostazol on adiponectin/adiponectin receptors and the Sirtuin 1 (SIRT1)/AMP-activated protein kinase (AMPK) signaling pathway to prevent high glucose (HG)-induced impairment of angiogenesis in vitro and in vivo. Methods and Results: Human umbilical vein endothelial cells (HUVECs) and human aortic smooth muscle cells (HASMCs) were cocultured in HG conditions. Adiponectin concentrations in the supernatant were significantly increased when HASMCs were treated with cilostazol but not significantly changed when only HUVECs were treated with cilostazol. Cilostazol treatment restored the expression of the adipoR1 and SIRT1 proteins and upregulated the phosphorylation of AMPKa1 in the HUVECs treated with HG but not adipoR2. Cilostazol prevented apoptosis and stimulated proliferation, chemotactic motility and capillary-like tube formation in HG-treated HUVECs through the adipoR1/AMPK/SIRT1 signaling pathway. In cilostazol-treated mice, recovery of the blood flow ratio after hindlimb ischemia and circulating CD34+CD45dim cells were significantly attenuated by adipoR1 knockdown but not adipoR2 knockdown. The expression of SIRT1, phosphorylation of AMPKa1/acetyl-CoA carboxylase and Akt/endothelial nitric oxide synthase in ischemic muscles were significantly attenuated by gene knockdown of adipoR1. Conclusions: Cilostazol prevents HG-induced endothelial dysfunction in vascular endothelial cells and enhances angiogenesis in hyperglycemic mice by upregulating the expression of adiponectin/adipoR1 and its SIRT1/AMPK downstream signaling pathway.
Implementation Strategies to Promote Measurement-Based Care in Schools: Evidence from Mental Health Experts Across the United States
Authors: Connors Elizabeth H , Lyon Aaron R , Garcia Kaylyn , Sichel Corianna , Hoover Sharon , Weist Mark D , Tebes Jacob
Published: November 2021

Background: Despite an established, comprehensive taxonomy of implementation strategies, minimal guidance exists for how to select and adapt strategies to specific services and contexts. We employed a replicable method to identify the most feasible and important implementation strategies to increase mental health providers’ use of measurement-based care (MBC) in schools. MBC is the routine use of patient-reported progress measures throughout treatment to inform patient-centered, data-driven treatment adjustments. Methods: A national sample of 52 school mental health providers and researchers completed two rounds of modified Delphi surveys to rate the relevance, importance, and feasibility of 33 implementation strategies identified for school settings. Strategies were reduced and definitions refined using a multimethod approach. Final importance and feasibility ratings were plotted on “go-zone” graphs and compared across providers and researchers to identify top-rated strategies. Results: The initial 33 strategies were rated as “relevant” or “relevant with changes” to MBC in schools. Importance and feasibility ratings were high overall for both survey rounds; importance ratings (3.61 - 4.48) were higher than feasibility ratings (2.55 – 4.06) on average. Survey 1 responses resulted in a reduced, refined set of 21 strategies, and six were rated most important and feasible on Survey 2: 1) assess for readiness and identify barriers and facilitators; 2) identify and prepare champions; 3) develop a usable implementation plan; 4) offer a provider-informed menu of free, brief measures; 5) develop and provide access to training materials; and 6) make implementation easier by removing burdensome documentation tasks. Provider and researcher ratings were not significantly different, with a few exceptions: providers reported higher feasibility and importance of removing burdensome paperwork than researchers, and providers reported higher feasibility of train-the trainer approaches than researchers; researchers reported higher importance of monitoring fidelity than providers. Conclusions: The education sector is the most common setting for child and adolescent mental health service delivery in the United States. Effective MBC implementation in schools has the potential to elevate the quality of care received by many children, adolescents and their families. This empirically-derived, targeted list of six implementation strategies offers potential efficiencies for future testing of MBC implementation in schools.
Landslide Susceptibility Region Mapping Using GIS, Analytic Hierarchy Process Model, and Multi-Criteria Analysis at the Chemoga Watershed, Upper Blue Nile, Ethiopia
Authors: Desalegn Hunegnaw , Mulu Arega , Damtew Banchiamlak
Published: November 2021

Landslide susceptibility consists of an essential component in the day-to-day activity of human beings. A landslide incident typically happening at a low rate of recurrence when compared and in contrast to other events. This might be generated into main natural catastrophes relating to widespread and undesirable sound effects. Therefore, based on this perception and merging with the expert approach that has been the propensity to encourage and defy extreme physical development to generate a methodology to use GIS, AHP, and Multi-criteria decision analysis for landslide susceptibility maps. A geographic information system is a grouping with additional methods, such as the method for multi-criteria decision making. MCDA techniques are applied under such circumstances to categorize and class decisions for successive comprehensive estimation or else to state possible from impossible potentiality with various landslides. Analytical Hierarchy Process (AHP) constructively applies for conveying influence to different criteria within Multi-criteria decision analysis. The causative landslide weights utilized within this research were elevation, slope, aspect, Soil type, Lithology, Distance to stream, Land use land cover, rainfall and drainage density achieved from various sources. Subsequently, to explain the significance of each constraint into landslide susceptibility weights of all factors were finding out AHP technique. Generally, landslide susceptibility maps of all factors were multiplied to their weights to acquire with the AHP technique. The result showed that the AHP methods are comparatively good quality estimators of landslide susceptibility identification within the chemoga watershed. As the result, the Chemoga watershed area of landslide susceptibility map classes was classified as 46.52%, 13.83%.18.71%, 15.39%, and 5.55% of the occurred landslide fall to very low, low, moderate, high, and very high susceptibility zones respectively. Performance and accuracy of modeled maps have been established using GPS field data and Google earth data landslide map and Area under Curve (AUC) of the Receiver Operating Characteristic curve (ROC). The research outcomes inveterate the very good test consistency of the generated maps. As the result, validation depends on the ROC specifies the accuracy of the map formed with the AHP merged through weighted overly method illustrated very good accuracy of AUC value 81.45%.
A Signature of Three MicroRNAs is a Potential Diagnostic Biomarker for Glioblastoma
Authors: Yazdi Ali Hosein , zarrinpour vajiheh , Moslemi Elham , ForghaniFard Mohammad Mahdi
Published: November 2021

Background: Glioblastoma (GBM) is by far the most common primary malignant neoplasm of the central nervous system. In spite ofsome progress in diagnosis and treatment, GBM patients still have a poor prognosis. Hence, to improve GBM diagnosis, finding novel non-invasive biomarkers, e.g., miRNA-based biomarkers,is of importance.Methods: A pair of 50 GBM and healthy samples were used. The expression of each candidate miRNA (i.e.,hsa-let-7c-5p, hsa-miR-206-5p, and hsa-miR-1909-5p)was measured using quantitative reverse transcription PCR. To show the roles of each miRNA and their biological effects on GBM development, in silico tools were used. Receiver operating characteristic (ROC) curves were performed to assess the diagnostic accuracy of each miRNA; the possible association of their expression with clinicopathological characteristics wasalso analyzed. To find out any association between the miRNA expression and GBM prognosis, in silico tools were used.Results: We showed the downregulation of hsa-let-7c-5pand hsa-miR-206-5p, and upregulation of hsa-miR-1909-5p in GBM tumor compared to healthy samples. No association was detected between the expression of each candidate miRNA and ‘sex’. Except for hsa-let-7c-5p, other miRNAs did not show any correlation with ‘age’ status. ROC curve analysis showed that the signature of candidate miRNAsis a potential biomarker distinguishing between GBM and healthy samples. Only hsa-miR-206-5p showed the association with poor prognosis in GBM patients.Conclusions: We demonstrated that the dysregulation of three candidate miRNAs may be used as a biomarker for GBM diagnosis. These results are beneficial in clinical management of GBM patients.
The role of preoperative 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) in retroperitoneal sarcoma
Authors: Jo Sung Jun , Kim Kyeong Deok , Lim So Hee , Kim Jinseob , Hyun Seung Hyup , Park Jae Berm , Lee Kyo Won
Published: November 2021

18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) scan was used to predict pathologic grade based on the maximum standardized uptake value (SUVmax) in soft tissue sarcoma and bone sarcoma. In retroperitoneal sarcoma (RPS), the effectiveness of PET scan was not well known. This study is designed to investigate the association of SUVmax with histopathologic grade and usefulness of 18 F-FDG PET/CT scan preoperatively. Patients undergoing primary surgery for retroperitoneal sarcoma with preoperative 18F-FDG PET/CT imaging were investigated between January 2001 and February 2020 at Samsung Medical Center. The relationship between SUVmax and histologic features was assessed. The association of SUVmax with overall survival (OS), local recurrence (LR), and distant metastasis (DM) was studied. Of the total 129 patients, the most common histologic subtypes were liposarcoma (LPS, 68.2%) and leiomyosarcoma (LMS,15.5%). The median value of SUVmax was 4.5 (range, 1- 29). The value of SUVmax was correlated with higher tumor grade (p < 0.001, Spearman coefficient 0.627) and mitosis (p < 0.001, Spearman coefficient 0.564) and showed a higher value in LMS (12.04±6.73) than in dedifferentiated liposarcoma (DDLPS, 6.32±4.97, p = 0.0054). The optimal threshold to distinguish high tumor grade was 4.8. High SUVmax group based on the above threshold showed poor prognosis in OS, LR, and DM (p < 0.001). SUVmax was correlated with pathologic parameters (tumor grade, mitosis) in RPS and was higher in the LMS group than DDLPS group. In addition, prognosis (OS, LR, DM) was poor at high SUVmax values (p < 0.001). The value of SUVmax 4.8 is the optimal threshold to rule out high-grade tumors and predict prognosis.
Development of Fused Deposition Modeling Using Five-Axis Machine and Printing Methods
Authors: zhang Haiguang , zhao Kunlong , Liu Di , Hu Qingxi , Lammer Herfried
Published: November 2021

Fused deposition modeling (FDM) is one of most widely used 3D printing technologies due to inexpensive equipment and materials, and easy to operate. FDM forms a 3D geometry by slicing a model along the XY-plane and assembling the resulting individual layers along the Z-axis, with extruded thermoplastic filaments. FDM printed parts usually need supporting structures, have stair step effect, and unfavorable mechanical properties. In order to address these deficiencies, a five-axis 3D printer and corresponding printing methods are proposed and developed in this paper. The 3D printer was designed five degrees of freedom through adding a platform that can rotate and swing. Based on the obtained results from different case studies, the discussed machine and methods could become more significant in industrial applications such as low cost, fabricating parts with better surface quality and lightweight structures.
COVID19 and Human Right To Food: Lived Experiences of the Urban Poor in Kenya with the Impacts of Government’s Response Measures, A Participatory Qualitative Study
Authors: Kimani-Murage Elizabeth Wambui , Osogo David , Nyamasege Carolyn Kemunto , Igonya Emmy Kageha , Ngira David Otieno , Harrington John
Published: November 2021

Background

Globally, governments put in place measures to curb the spread of COVID-19. Information on the effects of these measures on the urban poor is limited. This study aimed to explore the lived experiences of the urban poor in Kenya in the context of government’s COVID-19 response measures and its effects on the human right to food.
Methods

A participatory qualitative study was conducted in two informal settlements in Nairobi between January and March 2021. Analysis draws on eight focus group discussions, eight in-depth interviews, twelve key informant interviews, two photovoice sessions and three digital storytelling sessions. Phenomenology was applied to understand an individual’s lived experiences with the human right to food during COVID -19. Thematic analysis was performed using NVIVO software.
Results

The human right to food was affected in various ways. Many people lost their livelihoods affecting affordability of food due to response measures such as social distancing, curfew, and lockdown. The food supply chain was disrupted causing limited availability and access to affordable, safe, adequate, and nutritious food. Consequently, hunger and an increased consumption of low-quality food was reported. The government and other stakeholders instituted social protection measures. However, these were inadequate and marred with irregularities. Some households resorted to scavenging food from dumpsites, skipping meals, sex-work, urban-rural migration and depending on food donations to survive. On the positive side, some households resorted to progressive measures such as urban farming and food sharing in the community. Generally, there was a view that the response measures could have been more sensitive to the human rights of the urban poor.
Conclusions

The government’s COVID-19 restrictive measures exacerbated the already existing vulnerability of the urban poor to food insecurity and violated their human right to food. Future response measures should be executed in ways that respect the human right to food and protect marginalized people from resultant vulnerabilities.
Study On The Formation Mechanism of Cutting Surface of Carbon Fiber Reinforced Composites
Authors: Su Fei , Li Chunjie , Dong Guojun , Zheng Lei , Chen Bing
Published: November 2021

Carbon fiber-reinforced plastic (CFRP) is used widely in aerospace. The cutting mechanism of CFRP is markedly different from that of metals due to anisotropic and non-homogeneous material structure. The cutting mechanisms are highly dependent on the fiber orientation. The quality of the machined surface can be affected by the fiber fracture models. In this paper, based on the elastic foundation beam theory and the Hertzian contact theory, the cutting mechanics are established. And the cutting model is simulated by the three-dimensional micro-scale numerical model. Then, the continuous varying cutting mechanism and the sub-damage are deeply studied in detail by combining the cutting mechanics model and the simulation model. The results indicate that the fiber orientation θ=80° and θ=150° is the transition critical point of the fracture form. When θ=0°, the fiber failure mode is buckling-dominated. When 0°<θ<80° and 150°<θ<180°, the fiber failure mode is dominated by contact fracture. When 80°<θ<150°, the fiber failure mode is bending-dominated. The cutting mechanics model and finite element model can effectively reflect the evolution law of CFRP machined surface.
Investigating the concentration levels, distribution patterns, source identification and health risk assessment of PAHs, n-alkanes, hopanes, and steranes in deposited dust of Mashhad, Iran
Authors: mahdad Faezeh , Bakhtiari Alireza Riyahi , Moeinaddini Mazaher , Charlesworthc Susanne , Emrani Nima
Published: November 2021

Deposited dust (DD) in urban environments contains carcinogenic organic compounds. The Indoor air quality is greatly affected by heating, ventilation, and air conditioning systems (HVAC), and in the Middle East most of the buildings are equipped by HVAC on top of them. It is possible that the DD on the roof near this equipment would be transferred to an indoor area. For these reasons, 40 samples of the over the roof DD were prepared, and organic compounds (16PAH compounds, 20n-alkane homologs, 8hopanes, and 6steranes) of DD were extracted using Soxhlet and analyzed by GC-MS. Source identification of organic compounds conducted by ring classification, diagnostic ratios, and factor analysis (FA). The results showed that the average (±SD) of total PAHs, n-alkanes, hopanes and steranes in DD were 1356.00 (±291.45) ng kg−1dw, 3211.65 (±969.18), 146.37 (±79.45) and 469.76 (±188.25) µg.g_1dw, respectively. The highest concentration of organic compounds was in the city center, where traffic congestion is common. Diagnostic ratios of n-alkanes results showed the dominant source is vehicular emission. FA results indicated vehicular emission and biogenic sources. In agreement, the results of sterane and hopane profiles confirm these results. On the other hand, the PAHs diagnostic ratios results indicated petroleum combustion sources. In this regard, FA findings showed combustion from vehicular emission and natural gas and wood combustion were the main factors. Furthermore, the incremental lifetime cancer risk was calculated as 8.45× 10−12 for children and 9.80 × 10−7 for adults, and the imposed risk was negligible.
Unified method applied to the new Hamiltonian amplitude equation: Wave solutions and stability analysis
Authors: Rayhanul Islam S M
Published: November 2021

The new Hamiltonian amplitude (nHA) equation deals with some of the disabilities of the modulation wave-train. The main task of this paper is to extract the analytical wave solutions of the nHA equation. Based on the unified scheme, analytical wave solutions are attained in terms of hyperbolic and trigonometric function solutions. In order to prompt the underlying wave propagation characteristics, three-dimensional (3D), two-dimensional (2D) are illustrated from the solutions obtained with the help of computational packages Mathematica and also made comparisons between wave profiles for various values. The proposed method can also be used for many other nonlinear evolution equations.
A Novel Approach to the Fuzzification of Fields
Authors: Zeng Mingyi , Shi Fu-Gui , Wang Lan
Published: November 2021

In this paper, a novel approach to the fuzzification of field is introduced.
its characterizations are given. An L-fuzzy convexity can be induced by an L-fuzzy subfield degree, and an L-fuzzy field homomorphism is exactly an L-fuzzy convexity preserving mapping and an L-fuzzy convex-to-convex mapping.
A Microdosimetry Analysis of Reversible Electroporation In Scattered, Overlapping, And Cancerous Cervical Cells
Authors: Kumar Mayank , Mishra Ashutosh
Published: November 2021

In this paper,a numerical method for studying reversible electroporation on normal and cancerous cervical cells is introduced. This microdosimetry analysis has been done by a unique approach for extracting contours of free and overlapping cervical cells in the cluster from the External Depth field images19. The algorithm used for extracting the contours is a joint optimization of multiple level set function along with the Gaussian mixture model and Maximally Stable Extremal Regions. This contour is then imported a multiphysics domain solver, where variable frequency pulsed electric field is applied. The Trans-Membrane Voltage (TMV) developed across the cell membrane is then calculated using the Maxwell equation coupled with a statistical approach employing the asymptotic Smoluchowski equation, which calculates the generated temporal pore density. The numerical model was validated by successful replication of existing experimental approach that employed low-frequency uni-polar pulses on the overlapping cells to obtain reversible electroporation. Using several overlapping clumps of cervical cells, simulations are performed to match the experimental data. For high-frequency calculation, a combination of normal and cancerous cells is introduced to the computational domain. The cells are assumed to be dispersive and the Debye dispersion equation is a second-order partial derivative equation used for further calculations. The difference in time duration for reaching the threshold value of electroporation is seen between the normal and cancerous cervical cells due to their size and conductivity change. The drug and dye uptake modulation during the high-frequency electric field electroporation is advocated by a mathematical model.
SORG Algorithm to Predict 3- and 12-month Survival in Metastatic Spinal Disease: A Cross-Sectional Population-Based Retrospective Study.
Authors: Zegarek Gregory , Tessitore Enrico , Chaboudez Etienne , Nouri Aria , Schaller Karl , Gondar Renato
Published: November 2021

In this study, we recruited 40 patients with spinal metastatic disease
who were operated at Geneva University Hospitals by the Neurosurgery
or Orthopedic teams between the years of 2015 and 2020. We did an
ROC analysis in order to determine the accuracy of the SORG ML algorithm
and nomogram versus the Tokuhashi Original and Revised Scores.
The analysis of data of our independent cohort shows a clear advantage in
terms of predictive ability of the SORG ML algorithm and nomogram in
comparison with the Tokuhashi scores. The SORG ML had an AUC of 0.87
for 90-days and 0.85 for 1-year. The SORG Nomogram showed a predictive
ability at 90-days and 1-year with AUC’s of 0.87 and 0.76 respectively.
These results showed excellent discriminative ability as compared with the
Tokuhashi Original Score which achieved AUC’s of 0.70 and 0.69 and the
Tokuhashi Revised Score which had AUC’s of 0.65 and 0.71 for 3-month
and 1-year respectively. The predictive ability of the SORG ML algorithm
and nomogram were superior to currently used preoperative survival estimation
scores for spinal metastatic disease.
Determination of Sovereign Credit Rating Model for European Countries
Authors: Akin Isik
Published: November 2021

Credit rating agencies play a key role in financial markets, as they help to reduce asymmetric information among market participants via credit ratings. The credit ratings determined by the credit rating agencies reflect the opinion of whether a country can fulfil the liability or its credit reliability at a particular time. Therefore, credit ratings are a very valuable tool, especially for investors. In addition, the issue that credit rating agencies are generally criticised is that they are unsuccessful in times of financial crisis. Credit rating methodologies of credit rating agencies have been subject to intense criticism, especially after the 2007/08 Global Financial Crisis. Some of the criticised issues are that credit rating agencies’ methodologies are not transparent; they are unable to make ratings on time, and they make incorrect ratings. In order to create a more reliable credit rating methodology, the credit rating industry and the ratings determined by rating agencies need to be critically examined and further investigated in this area. For this reason, in this study credit rating model has been developed for countries. Supervisory and regulatory variables, political indicators and macroeconomic factors were used as independent variables for the sovereign credit rating model. As a result of the study, the new sovereign credit rating calculates exactly the same credit rating with Fitch Rating Agency for developed countries, but there are 1 or 2 points differences for developing countries. In order to better understand the reason for these differences, credit rating agencies need to make their methodologies more transparent and disclose them to the public.
Green Financing for Carbon-Free Growth: Role of Banks Marketing Strategy
Authors: Pimonenko Tetyana , Us Yana , Myroshnychenko Yuliya , Dubyna Olexiy , Vasylyna Tetyana
Published: November 2021

Nowadays, the climate change problems are on the international agenda, while increasing attention is paid to the role of green finance and bank activity in developing a climate-neutral future. This paper aims to investigate the scientific background devoted to bank marketing to determine the role of green finance in carbon-free economic growth and identify the potential research directions under this issue. The systematization of scientific publications presented in the Scopus database showed the growing tendency in publication activity concerning bank marketing and carbon-free economic growth. However, the scientific problem is a gap in studies devoted to investigating the role of financial marketing strategies in the bank sector for intensifying carbon-free economic growth. To gain the research goal, the authors conducted the bibliometric analysis using the VOSviewer software tools. Methodological tools of the research were the method for visualizing similarities between keywords. This study operates with the scientific articles published in the journals indexed in the Scopus database. The research period is 2000-2020. The research theoretically proved that green finance is one of the main triggers of carbon-free development. The obtained results of the bibliometric analysis identified four main research directions concerning the investigated topic such as 1) financial marketing in sustainable development; 2) financial management in environmental protection; 3) carbon markets; 4) international regulation in emission trading. The authors determined the contribution of scientists in developing the investigated issues. Most productive journals were highlighted. The findings determined the pioneer countries in exploring the analyzed topic. The current study findings are limited by the articles presented only in the Scopus database. Therefore, future research should expand the study sample to compare the articles presented in other reliable scientific databases such as the Web of Science.
The Impact of the Coronavirus Pandemic on the Economy of Ukraine: a Sectoral Analysis of the Consequences and Opportunities for Recovery
Authors: SABADASH VIKTVIKTOR V. , KHARCHENKO DIANA V.
Published: November 2021

The article examines the state and trends of the Ukrainian economy during the pandemic of coronavirus COVID-19, economic opportunities for economic recovery in the short term. The paper presents an analysis and structure of key sectoral socio-economic losses and losses (loss of income) by economic agents under the influence of the pandemic. The study identified and analysed the main economic groups of the consequences of COVID-19, such as: GDP reduction; decline in industrial production; significant reduction of revenues from economic activities of air carriers and maritime transport; shopping and entertainment centres, tourism industry; reduction of household incomes with a simultaneous increase in their expenditures; increase in profits of pharmaceutical companies and the gaming, educational and other online application's industry (in particular, food and medicine delivery); declining business and investment activity and growing investor demand for less risky assets in the Ukrainian market; changing trends in retail and online trade; digitalization of business processes. The paper examines the impact of the factor of “remote” and “hybrid” format of work on the employment market (both national and global dimension).
According to the results of the study, conclusions were made about the key current opportunities (projected) recovery of the national economy by sectors (areas of economic activity) in the post-covenant period, provided that new lockdowns are not introduced in autumn 2021 due to the spread of a new strain Delta. The expected recovery of the national economy is projected to be gradual and slow due to significant economic, political and epidemiological risks (so far small volumes of vaccination and the risk of a new wave of pandemic). Given the high uncertainty of global economic and security trends, small and weak economies should develop short-term national recovery strategies, focusing primarily on their own financial resources and economic opportunities, providing financial and legislative support to national companies and the domestic market.
Supersolid phase of a spin-orbit-coupled Bose-Einstein condensate: A perturbation approach
Authors: Martone Giovanni Italo , Stringari Sandro
Published: November 2021

The phase diagram of a Bose-Einstein condensate with Raman-induced
spin-orbit coupling includes a stripe phase with supersolid features. In
this work we develop a perturbation approach to study the ground state
and the Bogoliubov modes of this phase, holding for small values of the
Raman coupling. We obtain analytical predictions for the most relevant
observables (including the periodicity of stripes, sound velocities,
compressibility, and magnetic susceptibility) which are in excellent
agreement with the exact (non perturbative) numerical results, obtained
for significantly large values of the coupling. We further unveil the
nature of the two gapless Bogoliubov modes in the long-wavelength limit.
We find that the spin branch of the spectrum, corresponding in this
limit to the dynamics of the relative phase between the two spin
components, describes a translation of the fringes of the equilibrium
density profile, thereby providing the crystal Goldstone mode typical of
a supersolid configuration. Finally, using sum-rule arguments, we show
that the superfluid density can be experimentally accessed by measuring
the ratio of the sound velocities parallel and perpendicular to the
direction of the spin-orbit coupling.
Quantification of Carbon Dioxide (CO2), Methane (CH4), and Nitrous Oxide (N2O) Using Near Infrared Spectroscopy and Multivariate Calibration in High Humidity Levels
Authors: Ribessi Rafael , Jardim Wilson , Rohwedder Jarbas , Neves Thiago
Published: November 2021

In this work we developed a promising analytical method combining Fourier transform nearinfrared (FT-NIR) spectroscopic technique and first-order multivariate calibration using partial least-squares (PLS) model to simultaneously quantify the main greenhouse gases (GHG’s): methane (CH4), carbon dioxide (CO2), nitrous oxide (N2O) and water vapor (H2O). The models were built using 70 mixtures with different concentration of these gases, 0.25-32.0 ppm to CH4 and N2O, and 50-1100 ppm to CO2 and different values of relative humidity (52-85%, 20 ºC) in synthetic air. After preparing each of the mixtures, they were analyzed by using FT-NIR and a reference analytical technique based on gas chromatography with mass spectrometric detection (GC-MS). The FT-NIR spectrometer was coupled with a long optical path cell, with 105.6 meters of optical path. In sequence, the spectra of all mixtures and its concentration values for each gas were used to build the multivariate calibration models, using PLS regressions. For this, the mixtures were grouped with Kennard Stone algorithm, 50 samples to calibration set and 20 samples to prediction set. The values of RMSEP (root mean square error of prediction) obtained for each model are 0.66, 28.7 and 0.66 ppm, respectively, for CH4, CO2, and N2O. The limits of quantification (LOQ) for each PLS models are 0.26, 3.6, and 0.99 ppm, respectively, for CH4, CO2, and N2O. The results show the potentiality of application of this system to monitoring emission sources in which the concentration of these gases are relatively high, as urban centers, industrial areas, and landfills.
Understanding Elderly’s Place Attachment in Urban Parks Setting
Authors: Meganathan Kavitha , Azizul bin Azizui Muhammad Farid
Published: November 2021

Urban designers, planners and policy-makers are working together to meet the emerging demands as cities in the developed countries are growing at an increased speed and intensity. Therefore, a socio-economic conception is needed to be conceived and more deliberately assimilated in terms of urban planning and in regards to designing urban areas in order to develop cities sustainably so they are planned well. Since parks are public space they have a great importance in creating a social environment for people, particularly for those who live in cities. This is in addition to the, physical and ecological impacts of parks. Those who live in the city spend a little time in the edge of everyday life with their friends and families and, as such, they are distracted from social life. This situation adversely affects the elderly who need the most care in our busy daily life. This article seeks to address the gap in the field by exploring the phenomenon of the bonding between elderly people and place in urban parks in an analytical context and focuses on the core concept of place attachment which has gained traction over the past three decades because of the role it plays in explaining the consequences of the connection between people and place in term of predicting behaviors. This article aims to explore how elderly people who have exposed themselves to an environment develop place satisfaction and place attachment in the urban parks and to create more sustainable, civic and environmentally conscientious communities. Based on literature reviewed, this study proposes a conceptual framework of elderly’s source, dimension of place attachment in urban parks. It is anticipated that place satisfaction and place attachment contribute to elderly behavior and might improve their behavior in the urban park environment. This article further evaluates the affective and cognitive views as well as the commitment of the elderly to sustainable development.
A New Framework of Urban Serious Game to Empower the Smartness of Citizens
Authors: Lin Yang , Lin Chuanwei
Published: November 2021

With the Smart City concept gaining momentum around the world in recent years, Information and Communication Technologies (ICTs) have become increasingly popular and indispensable. However, existing criticisms claim that, in addition to Technology, the smartness of citizens should also be emphasized. In other words, it is essential to enable citizens to become involved in their cities as stakeholders. In this paper, a game-based approach to facilitate the involvement of citizens in civic life is taken. By analyzing some popular digital video games, Augmented Reality (AR) and theories from socialists and psychologists, a new Urban-gaming framework is built, which could be used for data collection, decision-making and other urban issues.
Immobilization of microorganisms in activated zeolite beads and alkaline pretreated straws for ammonium-nitrogen removal from urban river water
Authors: Tang Van Tai , Li Qiuhong , Rene Eldon R. , Behera Shishir Kumar , Maleki Afshin , Da Chau Thi , Phong Nguyen Tan
Published: November 2021

The non-treated wastewater from residential areas contains high concentrations of ammonium-nitrogen (NH4+-N). When discharged into the drainage water system, it deteriorates the water quality in urban rivers. This study used two types of materials to form eco-bags, using activated zeolite bead (AZB) and alkaline pretreated straw (APS), in geotextile bags for easy recovery and reuse. The AZB and APS provided the breeding habitat for the microorganisms that promoted biofilm formation on their surface. The immobilization of engineered denitrification microorganisms facilitated the removal of NH4+-N from the urban river water. The NH4+-N removal in the AZB and APS bags were in the range of 64–73%, and 56–61%, respectively, while the chemical oxygen demand (COD) removal in the AZB and APS bags ranged from 33–36%, and 30–31%, respectively. In addition, as evident from DNA and microbial community analysis, the microorganisms demonstrated a greater proclivity to grow and proliferate on the surface of AZB and APS and improved the water quality of urban rivers.
An Insight into the Polymeric Nanoparticles Applications in Diabetes
Diagnosis and Treatment
Authors: Sivakumar Ponnurengam Malliappan , Zarrabi Ali , Dehghani Parisa , Rad Monireh Esmaeili , Zarepour Atefeh
Published: November 2021

:

Diabetes Mellitus (DM) is a type of chronic metabolic disease that has affected millions of
people worldwide and is known with a defect in the amount of insulin secretion, insulin functions, or
both. This deficiency leads to an increase in the amounts of glucose, which could be accompanied by
long-term damages to other organs such as eyes, kidneys, heart, and nervous system. Thus, introducing
an appropriate approach for diagnosis and treatment of different types of DM is the aim of several
researches. By the emergence of nanotechnology and its application in medicine, new approaches
were presented for these purposes. The object of this review article is to introduce different types of
polymeric nanoparticles (PNPs), as one of the most important classes of nanoparticles, for diabetic
management. To achieve this goal, at first, some of the conventional therapeutic and diagnostic methods
of DM will be reviewed. Then, different types of PNPs, in two forms of natural and synthetic polymers
with different properties, as a new method for DM treatment and diagnosis will be introduced.
In the next section, the transport mechanisms of these types of nano-carriers across the epithelium, via
paracellular and transcellular pathways will be explained. Finally, the clinical use of PNPs in the
treatment and diagnosis of DM will be summarized. Based on the results of this literature review,
PNPs could be considered one of the most promising methods for DM management.
Diabetes/Dementia in Sub-Saharian Africa and Nigerian Women in the
Eye of Storm
Authors: Oghagbon Efosa K. , Prieto-Pino José , Dogoh Faeren , Ogiator Monday , Giménez-Llort Lydia
Published: November 2021

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In the next few years, the prevalence of diabetes mellitus (DM) is projected to dramatically increase globally, but most of the cases will occur in low-to-middle-income countries. Some of the major risk factors for diabetes accelerate the development of dementia in African-Americans, thus leading to a higher prevalence of dementia than Caucasians. Sub-Saharan Africa women have a disproportionately two-to-eight fold increased prevalence of dementia. In the eye of this storm, Nigeria holds the highest number of diabetics on the African continent, and its prevalence is rising in parallel to obesity, hypertension, and the population’s aging. The socio-economic impact of the rising prevalence of DM and dementia will be huge and unsustainable for the healthcare system in Nigeria, as has been recognized in developed economies. Here, we analyze the current situation of women's health in Nigeria and explore future perspectives and directions. The complex interplay of factors involved in diabetes and dementia in Nigerian women include key biological agents (metabolic syndrome, vascular damage, inflammation, oxidative stress, insulin resistance), nutritional habits, lifestyle, and anemia, that worsen with comorbidities. In addition, restricted resources, lack of visibility, and poor management result in a painful chain that increases the risk and
burden of disease in Nigerian women from youth to elderly ages. Heath policies to increase the ra-
tio of mental health professionals per number of patients, mostly in rural areas, foment of proactive
primary care centers, and interventions targeting adolescents and adult women and other specific
mothers-children pairs are strongly required for a sustainable development goal.
Medicinal Chemistry Strategies Towards SO2 Donors as Research Tools and Potential Therapeutics
Authors: El-Labbad Eman M , Ji Xingyue , Abouzid Khaled A.M. , Wang Binghe
Published: November 2021

SO2 is emerging as a possible endogenous signaling molecule in mammals. In addition,
SO2 has also shown pharmacological effects, presenting SO2 as a promising potential therapeutic
agent. The past decade has witnessed steady advances in the development of small molecule-based
SO2 prodrugs/donors with varied release mechanisms. Herein, we summarize various strategies employed
for SO2 prodrug design. The remaining challenges and issues will also be discussed.
Primary Antiphospholipid Syndrome with Livedo Reticularis is Linked to
Female Sex and Stroke and Negatively Associated with Thyroid Disease
Authors: Carvalho Jozélio Freire , de Araujo Roberto Paulo Correia , Skare Thelma Larocca
Published: November 2021

Aim:

To study the clinical and laboratory findings between patients with primary Antiphospholipid
Syndrome (pAPS) with and without LR.

Background:

Livedo Reticularis (LR) is a common manifestation of Antiphospholipid Syndrome
(APS). Although no previous study evaluated patients with and without LR.

Methods:

A transversal study including 66 pAPS patients was performed. Demographical, anthropometric,
medication use, antiphospholipid antibodies profile data were evaluated, and LR's clinical
and laboratory features. Patients were subdivided into one of two groups: pAPS with LR and
pAPS without LR.

Results:

Both groups were alike concerning demographics and anthropometrics. Interestingly, the
frequency of stroke (28.5 vs. 7.5%, p=0.04), as well as of Sneddon’s syndrome (100 vs. 30.0%,
p<0.0001), were higher in pAPS with LR than the other group. Conversely, patients in the pAPS
without LR group had more thyroidopathy than those in the pAPS with LR group (80% vs. 50% %,
p=0.03).

Conclusion:

Patients with pAPS and LR have more stroke and seem to be protected from thyroidopathy.
Careful follow-up of these patients is therefore advised.
La política criminal frente al ciberdelito sexual contra niños, niñas y adolescentes en Colombia
Authors: Tirado-Acero Misael , Cáceres-Tovar Víctor Manuel
Published: November 2021

La problemática del abuso sexual contra niños, niñas y adolescentes en Colombia no evidencia mejorías, pues las cifras de conductas punibles cometidas reflejan un constante incremento, lo cual se agudiza en el emergente ciberespacio, donde los ciberdelitos sexuales implican nuevos desafíos. Por ello, este artículo busca establecer si la política criminal jurídica actual del Estado colombiano basta o no para afrontar esta emergente problemática. Para ello se analiza el ciberespacio como nuevo escenario y se ofrece una relación elemental de las principales conductas constitutivas de ciberdelitos sexuales. Como conclusión, se establece la necesidad de un nuevo paradigma de política criminal que proponga estrategias en que la prevención, y no el populismo punitivo, sea la principal medida para afrontar esta problemática, de lo cual hay un ejemplo en política económica y social.
Cambiando de mentalidad. El proceso de transformación del Ejército Nacional de Colombia (2011-2018)
Authors: Trujillo-Rodríguez Maritza Andrea , Valencia-Agudelo Germán Darío
Published: November 2021

Entre 2011 y 2018, el Ejército Nacional de Colombia emprendió cambios importantes con el fin de transformarse de cara a los retos del futuro, lo cual coincidió con el proceso que llevaría al Acuerdo Final con las FARC-EP, si bien se dio por iniciativa del propio Ejército. Este artículo analiza la propuesta de cambios cognitivos que hizo el Ejército en este periodo y su articulación con el posacuerdo, siguiendo el enfoque de los nuevos institucionalismos en ciencias sociales. Se recurrió a entrevistas y a una revisión de los planes militares y de reestructuración organizacional. Se concluye que el Ejército ha buscado introducir planificadamente cambios institucionales en la mentalidad, los hábitos y la conducta de sus miembros mediante un nuevo comando, una reorganización administrativa y una nueva concepción ideológica del antiguo adversario.
Medical Ethics for the Military Profession
Authors: Bricknell Martin , Miron Marina
Published: November 2021

This paper summarizes medical ethics in the military profession to raise military leaders’ awareness of Military Medical Ethics (MME) and the ethical issues that may impact their medical services and personnel. First, it summarizes core concepts, including the four principles of medical ethics (autonomy, beneficence, non-maleficence, and justice), the two legal frameworks for the use of military force in war, jus ad bellum and jus in bello, and the concept of dual loyalty. It then examines MME issues during conflict, in garrison healthcare, and during the COVID-19 epidemic. Finally, it concludes by arguing that MME is an important domain of military ethics that should be taught to military leaders to complement the detailed education of MME for military medical professionals.
Influencia de estilos de liderazgo en comportamiento innovador de alumnos de educación militar superior tecnológica
Authors: Noreña-Chavez Diego , Guevara-Moncada Rubén , Bustamante-Zuñiga Domingo Ricardo
Published: November 2021

Esta investigación replica el estudio de la influencia de los estilos de liderazgo en el comportamiento innovador de cadetes peruanos de Norena-Chavez et al. (2021), en una muestra de 200 alumnos del Instituto de Educación Superior Tecnológico Público del Ejército-ETE (Lima, Perú). Se emplea la técnica de ecuaciones estructurales utilizando mínimos cuadrados parciales (PLS-SEM). Se confirmó que existe influencia de los estilos de liderazgo transformacional y transaccional sobre el comportamiento innovador de los alumnos. De acuerdo con la varianza explicada, el liderazgo transformacional explica el 47 % y el liderazgo transaccional, el 59 % de la variabilidad del comportamiento innovador. Esta investigación contribuye a mejorar la comprensión de la relación de los estilos de liderazgo y del comportamiento innovador en el ámbito militar.
The United Nations and 21st century security challenges in Colombia
Authors: Galindo-García Fredy Leonardo , Aristizábal-Murillo Juan Carlos
Published: November 2021

Multifaceted 21st-century security challenges, such as terrorism, pandemics, illegal migration, and drug trafficking, permanently question the adequacy of both state and global organizations to guarantee general wellbeing, the rule of law, and the protection of human rights. In this sense, the United Nations (UN) has received the brunt of the criticism despite its growing responsibilities, the complexity of the threats, and its decision-making structure’s limitations. This paper examines the UN’s effectiveness in addressing Colombia’s major security challenges, suggesting that providing adequate assistance to build state capacity is key to reducing power vacuums that foster both deviant globalization and embryonic security challenges.