bluuebunny/crossref_metadata_2025 huggingface dataset:
Advancements in nanomedicine: Targeted drug delivery systems for cancer treatment
Authors: Alajmi Abdulrahman Amer , Al Otaibi Sanytan Ghazy , Alzubidi Abdullah Hzam Ali , Alanazi Ahmad Asri Awad , Almorshed ‏Abdullah Saleh Abdullah , Alrbian Abdullah Abdulrahman Mohammed
Published: October 2024

Background: Nanomedicine has emerged as a revolutionary approach in cancer treatment, enabling targeted drug delivery that enhances therapeutic efficacy while minimizing systemic toxicity. The rapid advancement in nanotechnology has led to the development of sophisticated drug delivery systems that optimize the pharmacokinetics and pharmacodynamics of anticancer agents. Aim: This article aims to review the progress in nanomedicine, focusing on targeted drug delivery systems developed for cancer treatment, highlighting their mechanisms, types, and clinically approved formulations. Methods: A comprehensive literature review was conducted to collate data on the history, mechanisms of action, types of nanomedicines, and their clinical applications in cancer therapy. Key databases were searched for relevant studies, clinical trials, and regulatory approvals of nanomedicines. Results: The review reveals a significant evolution in the field of nanomedicine since its inception, with various nanocarriers, including liposomes, dendrimers, and polymeric nanoparticles, being developed to enhance drug solubility and improve therapeutic targeting. Clinically approved formulations such as Doxil® and Abraxane® exemplify the successful integration of nanotechnology into oncology, demonstrating improved patient outcomes and reduced side effects. Conclusion: Advancements in nanomedicine have paved the way for innovative cancer therapies that leverage targeted drug delivery systems to improve treatment efficacy and safety.
SITUACIÓN ACTUAL DE Scyphophorus acupunctatus GYLLENHAL (COLEOPTERA: CURCULIONIDAE) EN MÉXICO
Authors: Recéndiz-De la Mora Milton Brandon , Niño-Maldonado Santiago , Gómez-Moreno Vannia del Carmen , Reyes-Muñoz Jesús Lumar , Venegas-Solís Yatziri Estefanía , Valenzuela-Ceballos Sara , Sánchez-Galván Homero , Cano Luis Alberto
Published: October 2024

RESUMEN. El picudo del agave (Scyphophorus acupunctatus Gyllenhal, 1838) pertenece a la familia Curculionidae, es un insecto originario de México, distribuido en la mayoría del territorio nacional. Es una especie muy estudiada, la mayoría de las investigaciones lo describen como la principal plaga del cultivo del agave y se le adjudican cuantiosas pérdidas económicas en industrias textiles, ornamentales, tequileras y mezcaleras. A pesar de ser una especie muy estudiada, poco se ha investigado a cerca de su distribución en los diferentes biomas o tipos de vegetación y en la actualidad no existen estudios que hayan analizado su distribución y/o su presencia en los diferentes gradientes altitudinales. Por lo anterior, en esta investigación se documenta la distribución actual del picudo en México dentro de los diferentes biomas y altitudes presentes en el país. Además, se registran nuevas distribuciones estatales y hospederos para la especie. Con los resultados obtenidos, se sugiere que se siga investigando este aspecto para determinar la preferencia de la especie por las altitudes y los elementos bióticos y abióticos que puede servir en el manejo y control de la especie para disminuir el daño económico que causa a nivel nacional.
Una aproximación a la Filosofía de la Química
Authors: Contreras Ricardo
Published: October 2024

La química ha adquirido una alta preponderancia en la vida humana, razón por la cual es imperiosa la necesidad de reflexionar sobre los aspectos que integran su paradigma, y sobre su autonomía frente a las demás ciencias fácticas. Se toma como punto de partida para justificar esta autonomía, el marco conceptual derivado del sistema periódico de los elementos químicos. En el presente artículo de divulgación se ha realizado una exposición sistemática de este y otros aspectos que justifican y configuran una filosofía de la química, como un área dentro de la filosofía de la ciencia, que genera el espacio más idóneo para la reflexión sobre aspectos fundamentales conceptuales, metodológicos, lingüísticos, históricos y éticos de la química. Se exponen argumentos acerca de la necesidad de una filosofía de la química, sobre la importancia histórica de la filosofía atomista, sobre las concepciones de la materia, el flogisto y la influencia de los alquimistas, hasta llegar al concepto de elemento químico y al sistema periódico. Adicionalmente, se plantea que dentro de la filosofía de la química cabe una reflexión de los aspectos bioéticos en los cuales la química tiene responsabilidad, sobre el concepto de desarrollo sostenible y la química verde.
Synthesis, crystal and molecular structure, and hydrogen-bonding patterns in hydantoin-L-aspartic acid
Authors: Delgado Gerzon , Mora Asiloé , Contreras Jines , Bruno-Colmenarez Julia , Atencio Reynaldo
Published: October 2024

Hydantoin-L-aspartic acid, C5H6N2O4, crystallize in the orthorhombic system with space group P212121 (Nº19), Z=4, and unit cell parameters a= 7.597(1) Å, b= 8.591(1) Å, c= 9.447(1) Å, V= 616.6(2) Å3. In the crystal structure of the title compound the molecules are joined by N---H···O and O---H···O hydrogen bonds into chain and cyclic structures with graph-set C(4), C(6), C(8), R33(15), R44(20) forming a three-dimensional network.
Caracterización estructural de los ácidos orto, meta y para-metilhipúricos
Authors: Guillén Marilia , Ramírez Jeans , Mora Asiloé , Koteich Sonia , Villarroel Marlin , Contreras Jines , Delgado Gerzon
Published: October 2024

En este trabajo se presenta la cristalización y estudio estructural de los ácidos isómeros orto, meta y para-metilhipúrico.Estos materiales se caracterizaron mediante técnicas de FT-IR, 1H-RMN y 13C-RMN, y análisis térmico (TGA-DTA). Elestudio por difracción de rayos-X indica que los isómeros orto y meta cristalizan en celdas monoclínicas con grupoespacial P21/n y C2/c, mientras que el isómero para cristaliza en una celda ortorrómbica con grupo espacial P212121. Elempaquetamiento cristalino de los tres compuestos está gobernado por interacciones intermoleculares de enlace dehidrógeno del tipo O--H···O y N--H···O formando redes tridimensionales.
Study of catalytic activity on hydrogenation reactions of 1-hexene by RuCl2(Py)4 and RuCl2(DMSO)2(NC5H4CO2Na)2 supported on functionalized MCM-48
Authors: Vielma Joel , Cardenas Jose , Fontal Bernardo , Contreras Ricardo , Reyes Marisela , Fonseca Yuraima , Cardozo Eduardo , Araque César
Published: October 2024

Two hybrid catalysts were synthesized: (I) from dichlorotetrakis(pyridine)ruthenium(II) [RuCl2(Py)4] and (II) cisdichlorobis (dimetylsulfoxide)bis(sodiumnicotinate)ruthenium(II) [RuCl2(DMSO)2(NC5H4CO2Na)2] supported on MCM-48 functionalized, using post-synthesis method with [3-(2-aminoethylamino)propyl]trimethoxysilane and triethoxymethylsilane as anchoring and passivation ligands, respectively. The catalysts were characterized using infrared spectroscopy (FTIR), mass spectrometry (MS), thermogravimetric analysis (TGA-DSC), nitrogen adsorptiondesorption, scanning electron microscopy and energy dispersive X-ray analysis (SEM-EDX). Studies of catalytic activity were carried out in hydrogenation reactions and the reactions parameters (time, temperature, substrate/catalyst ratio and H2 pressure) were optimized. Supported complexes are chemiospecific to produce hexane and showed 100% conversion under optimal conditions. Catalysts were reused up to five times with a decrease about 30% of catalytic activity.
IA: herramienta pedagógica para el desarrollo del pensamiento crítico en Español General en la UNAH
Authors: Aguilar Andino Joanna Marie , Buezo Rodríguez Digna Gloria
Published: October 2024

El uso de la ia por sí sola no es la respuesta para la mejora en la calidad educativa, sino emplearla de modo que se permita la participación interactiva del estudiante, demostrando que no solo es capaz de recabar datos de una ia, sino analizar resultados para generar un criterio propio, compartir ideas y producir soluciones a problemáticas sociales. La metodología se dirigió a crear un ambiente e-learning adaptativo. Se seleccionó la estrategia pedagógica del aprendizaje individualizado, para lograr la personalización del proceso de enseñanza. Se inició con la aplicación del test de estilos de aprendizaje de Kolb, que permitió que el estudiante identificara su manera de aprender para luego seleccionar qué técnica de estudio es más eficaz para él. Este modelo se basa en los estilos convergente, divergente, asimilador y adaptador. Una vez identificados esos estilos con sus respectivas características, cada alumno eligió las estrategias de aprendizaje más apropiadas y procedió al estudio del contenido. El docente facilitó al estudiante recursos de acuerdo con los estilos de aprendizaje principales y los guio mediante rúbricas a la realización de las actividades de evaluación programadas, tales como reseñas y debates usando ChatGPT.
From Post-feminism to ‘Dildocracy’: Sex Industries andHappy Woman’s Biopolitics
Authors: Pinto Pedro
Published: October 2024

Standing on a feminist and queer theoretical framework, this paper draws attention to the fresh ‘pinking’ of sex industries by the Portuguese media and its reproduction of a post-feminist ideology of women’s sexual empowerment, conveyed by heteronormative discourses of bodily self-surveillance and consumerism. With the embracing of neo-liberal market values over the last years, the re-sexualisation of ‘femininity’ has become an increasingly dominant expression in the Portuguese mainstream culture. However, the democratisation of sexual discourse is still an ongoing process in this country, owing to a very long dictatorial regime (1926–1974) held by an ultra-conservative mentality and a system of strict censorship. Although women’s representations as heterosexual desiring subjects have proliferated throughout the whole media spectrum, the first evidences of the sex industries’ ‘feminisation’ emerged only very recently within the Portuguese mainstream imagery.Happy Woman– the Portuguese best-selling women’s magazine – is on the frontline of this late paradigm shift by openly bringing the contemporary lexicons of erotica fiction and striptease culture into its pages. Approaching the analysis in a poststructuralist vein, I aim to deconstruct the representational politics of women’s bodies and desire inHappy Woman’s textual contents dedicated to the new trends of sex industries. In particular, while discussing how Portuguese women are being discursively introduced to an apparatus of scripts regarding sex toys, pharmacological products and sex work, this article locates ‘dildocracy’ as an ultimate development in post-feminist discourses – fully engaged with the capitalist industrialisation of sexual difference.
Critical feminist projects forrevoltingtimes
Authors: Fine Michelle
Published: October 2024

This short piece considers the role of critical feminist psychology as a provocative intervention in times of widening inequality gaps, when gender, race/culture and class are primary axes of dispossession. By drawing on the work of the Public Science Project, a collective of researchers and activists at the Graduate Center, City University of New York, who have been engaged for a decade in critical participatory research, the essay describes our research on how global capitalism and neo-liberal policy regimes undermine women’s well-being, particularly women of colour and then recruit psychologists to scrutinise them ‘as if’ they were the site of risk; and then how feminist psychologists and activist colleagues can engage research for critical resistance. The essay ends with images of critical participatory action research projects which have refused to engage surveillance on women and have been designed instead with collectives of youth and young women, to challenge dominant representations, to provoke policy and action for justice, and to embrace solidarity with social movements.
Unlocking Innovation in Crop Resilience and Productivity: Breakthroughs in Biotechnology and Sustainable Farming
Authors: Khan Naeem
Published: October 2024

Recent advancements in agricultural biotechnology and sustainable practices are revolutionizing crop production and resilience, addressing global food security challenges. This review highlights cutting-edge innovations in plant sciences, including genetic engineering, genome editing technologies, and biotechnological interventions that enhance crop resistance to biotic and abiotic stresses. It discusses the integration of precision agriculture and digital farming tools that optimize resource use and boost productivity, providing data-driven insights for better crop management. Additionally, sustainable agricultural practices such as agroecology, organic farming, and integrated pest management are examined for their potential to reduce environmental impact while maintaining high yield. The review investigates the key practices like conservation tillage, crop rotation, and biological pest control, emphasizing their roles in enhancing soil health, biodiversity, and agricultural resilience. Significant contributions of biotechnological interventions, including genetic engineering and genome editing, are explored for developing stress-resistant and high-yield crop varieties. Moreover, the integration of precision agriculture and digital farming technologies is discussed for their potential to optimize resource utilization and improve crop management through advanced data analytics.
ASSESSING POTATO CULTIVATION TECHNIQUES IN PAKISTAN: AN ANALYSIS OF EXISTING METHODS AND IDENTIFIED GAPS
Authors: IRFAN MF , FATIMA N , ALI F , HAIDER MZ
Published: October 2024

The potato is an important crop in vegetables. It is grown in sandy to clay-loamy soil in the winter season. Potassium and vitamin C are abundant in potatoes. Both governmental and private agriculture extension services actively educate farmers about suggested techniques for producing potatoes and offer guidance on how to implement these practices. This study aimed to investigate the discrepancy between accepted and advised potato production technology techniques. Pakistan's primary potato hub is Okara. Tehsil Okara was selected randomly from 3 tehsils (Okara, Depalpur, Renala Khurd) of district Okara. A random sampling was carried out for 120 Okara potato growers, the study's key data were gathered through a field survey. According to the survey, most farmers were aware of the suggested potato production technology and many had already embraced it. However, a sizable portion did not follow the advised guidelines. Therefore, to get a high yield of potatoes per acre, it is necessary to strengthen the efforts of extension services and implement more advanced advice. Extension activities must be adjusted to farmers' needs.
KNOWLEDGE AND PRACTICE OF NURSES REGARDING TRACHEOSTOMY CARE
Authors: AMIR S , SADDIQUE H , JABEEN R
Published: October 2024

Tracheostomy is a common procedure in critical care settings for patients requiring prolonged ventilation or airway management. Nurses play a crucial role in tracheostomy care, which demands comprehensive knowledge and adherence to evidence-based practices to prevent complications. Objective: This study aimed to assess the knowledge and practices of nurses regarding tracheostomy care at Jinnah Hospital Lahore. Methods: A descriptive cross-sectional study was conducted from January 2024 to July 2024 at Jinnah Hospital Lahore. A total of [specify sample size, e.g., 150] registered nurses working in different wards and intensive care units (ICUs) were selected through simple random sampling. Data were collected using a structured questionnaire, which included sections on demographic information, knowledge, and practices. Knowledge and practice scores were categorized as good, moderate, or poor. Data analysis was performed using SPSS version 25.0, employing descriptive statistics and chi-square tests to identify associations between variables. Results: The study revealed that 60% of the nurses had moderate knowledge regarding tracheostomy care, while 25% demonstrated good knowledge, and 15% had poor knowledge. In terms of practice, 54.7% of nurses reported moderate adherence to tracheostomy care protocols, 30% had good practices, and 15.3% demonstrated poor practices. A significant association was found between formal training in tracheostomy care and higher knowledge and practice scores (p < 0.05). Conclusion: The findings indicate that most nurses possess moderate knowledge and practices concerning tracheostomy care, with notable gaps in training and adherence to standardized protocols. The study highlights the need for structured training programs and continuous professional development to enhance nurses' competency in tracheostomy care and improve patient outcomes.
Pelatihan Personel Pemandu Parkir Pesawat Udara (Marshalling) Bagi Personel Bandar Udara
Authors: Kardi Kardi , Agustono Agustono , Sundoro Sundoro , Adriansyah Feri , Pratiwi Ayu Kumala , Kusumah M. Chandra
Published: October 2024

Pelatihan personel pemandu parkir pesawat udara (marshalling) merupakan pelatihan yang dilaksanakan untuk meningkatkan kompetensi dan pengetahuan bagi SDM Penerbangan terkait prosedur dan pelayanan pemanduan parkir pesawat udara. Standar kompetensi personel pemandu parkir pesawat udara sebagaimana diatur pada Peraturan Menteri Perhubungan Nomor PM 37 Tahun 2021 tentang personel bandar udara disebutkan bahwa setiap personel pemandu parkir pesawat udara diharapkan mampu menangani kegiatan pemanduan parkir pesawat udara fixed wings, mampu melakukan pemanduan pesawat udara fixed wings dengan hand signal. Pelatihan ini diberikan kepada personel penerbangan pada stakeholder/perusahaan penerbangan yang belum memiliki sertifikat marshalling di instansi sekitar Politeknik Penerbangan Indonesia Curug (PPI Curug). Pelatihan ini perlu diselenggarakan dengan tujuan sebagai upaya peningkatan kompetensi sumber daya manusia yang perofesional dan handal pada bidang Penerbangan, agar sejalan dengan peraturan yang berlaku terkait sertifikasi personel bandar udara. Selain mendapatkan pengetahuan dan keterampilan, peserta pelatihan akan mendapatkan sertifikat kompetensi marshalling sebagai hasil akhir dari kegiatan pelatihan ini.
Pelatihan Dasar Las Listrik untuk Masyrakat Sekitar Politeknik Penerbangan Palembang
Authors: Setiyo Setiyo , Soleh Asep Muhamad , Handayani Ni Putu Heni , Trema Frendy Khan
Published: October 2024

Pengelasan dapat diartikan sebagai proses penyambungan dua buah logam sampai titik rekkristalisasi logam, dengan atau tanpa menggunakan bahan tambah, dan menggunakan energi panas sebagai pencair bahan yang akan di las. Kegiatan pengabdian kepada masyarakat ini berupa kegiatan pelatihan dasar las listrik yang bertujuan untuk memberikan pengetahuan dan keterampilan bagi masyarakat dalam bidang pengelasan menggunakan peralatan las listrik. Sedangkan manfaat dengan diberikannya pengetahuan keterampilan tersebut, maka para peserta dapat menggunakan alat las listrik dengan benar, menerapkan prosedur keselamatan saat melakukan pekerjaan las, dan terciptanya lapangan pekerjaan baru. Kegiatan pengabdian kepada masyarakat dilaksanakan di Bandar Udara Kalimarau Berau dengan peserta berasal dari pegawai bandar udara beserta masyarakat di sekitarnya. Metode yang digunakan yaitu berupa pelatihan yang dilakukan dengan pemberian teori dan praktik pengelasan. Peserta dibekali dengan materi keselamatan dan kesehatan kerja sebagai prosedur praktik pengelasan menggunakan alat las listrik. Pelaksanaan kegiatan pengabdian kepada masyrakat berhasil meningkatkan pengetahuan peserta dengan nilai rata-rata baik yang diukur dari hasil praktik pengelasan. Semoga dengan adanya kegiatan ini dapat meningkatkan keterampilan masyarakat di sekitar bandar udara dalam bidang las listrik.
On the Process of Prefixization and Prefixoids in Turkish
Authors: Sarı İsa
Published: October 2024

Prefixoids are the left-most elements attaching to roots or stems, which emerge from lexemes, and behave like derivational or inflectional affixes tending to slightly grammaticalize to a limited extent, showing an increase in productivity. In Turkish, certain adjectival constituents of the ADJ+N type compounds like ana 'lit. mother=PFmain, PFprimary' as in anafikir 'gist', baş 'lit. head=PFmain' as in başkent 'capitol', or ön 'lit. front=PFpre-' as in ön(-)basım 'pre-edition' show this tendency and are used productively to name concepts by behaving like prefixoids in spontaneous naming needs to fill the lexical gaps. Thus, though Turkish does not have an established prefixation mechanism typologically, these elements give rise to a blurry and controversial territory between compounding and prefixation. In the present study, such adjectival constituents will be investigated within the continuum between compounding and affixation, and it will be advocated that these constituents are at the very beginning of a morphologization/grammaticalization process.
A Comparative Analysis of Rhetorical Organization of English and Turkish Master’s Thesis Introductions on Turkish Sign Language
Authors: Geçikli Merve , Gür Cansu
Published: October 2024

The present study investigates the rhetorical organization of introductions in English and Turkish master’s theses on Turkish Sign Language (Türk İşaret Dili [TİD]). This study aims to compare the structural patterns and rhetorical strategies used in the introduction sections of master’s theses in two languages, using Swales’ CARS model. Through corpus-based analysis, this study examines how writers establish the research space, articulate the gap in the literature, and present their research purpose and objectives within the context of TİD studies. By adopting a comparative approach, this study contributes to our understanding of cross-linguistic and cross-cultural variations in academic discourse practices, particularly within TİD research. The findings offer insights into the linguistic and rhetorical conventions that shape academic writing in English and Turkish.
Kutadgu Bilig ve Divanu Lugati’t-Türk’te Geçen Astronomik Unsurlardaki İsim Karışıklığı ve Çözüm Teklifi
Authors: Güneş Hasan Ali
Published: October 2024

Gökyüzü, gezegenler ve yıldızlar tarih boyunca insanlığın merakını cezbetmiş ve pek çok farklı milletin ve medeniyetin sanat eserinde kendilerine yer bulmuştur. Zaman zaman ilah olarak da kabul edilen gök cisimleri, insanlar tarafından hayranlık, korku ve merakla izlenmiştir. Bu merak üzerine yapılan gözlemler zamanla astronomi ve astrolojiyi doğurmuştur.
Türk Dilinin iki kadim eseri Kutadgu Bilig ve Divanu Lugati’t-Türk’te de gökyüzü, gezegenler, yıldızlar ve takımyıldızlarla alakalı detaylı gözlemlere ve bilgilere yer verilmiştir. Bu eserler üzerine uzun yıllar boyunca kapsamlı çalışmalar yapan araştırmacıların gökyüzü terimlerine farklı farklı manalar verdikleri bu sebeple de bu terimlerin anlamlarında bir karışıklık olduğu gözlenmektedir.
Bu çalışmada, bu eserlerde yer alan Karakuş, Terazi, Bakırsukun,Yıldrık, Adgır gibi gezegen, yıldız, takımyıldız isimlerinin günümüzde hangi isimlerle anıldıkları tespit edilerek bu gök cisimlerini adlandırmadaki karışıklık çözülmeye çalışılacaktır.
Dede Korkut Metni Üzerine Yeni Bir Okuma Teklifi: ören evüŋ ṭāyifi
Authors: Özçelik Sadettin
Published: October 2024

2017 yılına kadar Dede Korkut’un Dresden ve Vatikan yazmalarının varlığı biliniyordu. Bu nedenle metinler üzerindeki araştırmalar bu iki yazma üzerinden sürmekteydi. 2017 yılında Ankara yazması, 2019’da Günbed yazması ve 2022 yılında Bursa yazması bulundu. Böylece varlığı bilinen Dede Korkut yazmalarının sayısı beşe çıkmış oldu. Bir metnin farklı yazmaları metindeki yazım yanlışlarını veya metinle ilgili yanlış okumaları, tereddütleri aydınlatabilir. Bu nedenle son beş yılda bulunmuş olan Dede Korkut yazmaları arasındaki yazım farklılıkları da metnin okunma, anlam vb. sorunlarının çözülmesi bakımından önemlidir. Ancak bazı durumlarda yazmalardaki ortak yanlışların metnin okunmasını güçleştirebildiği de söylenebilir. Bu nedenle metnin bağlamı dikkate alınarak ortak yanlışların dikkatle ve özenle yeniden incelenmesi gerekir.
Dede Korkut yazmalarında görülen yazım farklılıklarının çoğu müstensihlerden kaynaklanır. Yazmalardaki farklılıkların bir kısmı yazım yanlışlıklarıdır. Ancak ayrıca müstensihlerin bu metinlerin kelimelerini, söz kalıplarını ve cümlelerini değiştirdikleri veya metinden bazı kelimeleri, söz kalıplarını ve cümleleri çıkardıkları görülür. Metinlerde yazım yanlışlıkları ile eksikliklerin bir arada olduğu hatta anlatılan konu ile ilgili yer değiştirmelerin bulunduğu kısımların iç içe girdiği çok şaşırtıcı durumların ortaya çıkması da mümkündür.
Sözünü ettiğimiz şaşırtıcı yanlışların örnekleri, Dede Korkut’un mukaddime kısmındaki kadın tipleri metninde geçer. İşte bu makalede söz konusu metnin yanlışları dört yazma üzerinden ele alınarak değerlendirilmekte ve düzeltme teklifleri sunulmaktadır.
Doğu Türkistan’daki Köy Adlarının Değiştirilmesinin Toplumdilbilim Açısından İncelenmesi
Authors: Eruygur Adilcan
Published: October 2024

Bu çalışma, Çin hükümetinin Doğu Türkistan'daki köy adları nı sistematik olarak değiştirme politikasını toplum dilbilim açısından değerlendirmektedir. Çin hükümeti, Doğu Türkistan'da Uygur Türklerinin kültürel, dini ve tarihi kimliklerini ortadan kaldırmayı hedefleyen kapsamlı bir asimilasyon politikası yürütmektedir. İnsan Hakları İzleme Örgütü (HRW) ve Norveç merkezli Uyghur Hjelp'in sağladığı veriler, yaklaşık 630 köy adının dini, tarihi veya kültürel adlardan Çin Komünist Partisi'nin ideolojik değerlerini yansıtan isimlere değiştirildiğini ortaya koymaktadır. Bu makale, köy adlarının değiştirilmesinin Uygur kimliği ve kültürel mirası üzerindeki etkilerini toplum dilbilim, postkolonyal teori ve Antonio Gramsci’nin kültürel hegemonya kavramları çerçevesinde incelemektedir. Çalışmanın teorik çerçevesi, dil ve kimlik arasındaki bağlantıyı irdeleyerek, yer adlarının toplumsal hafıza ve kimlik üzerindeki önemini tartışmaktadır. Metodoloji bölümünde, HRW ve Uyghur Hjelp tarafından 2009-2023 yılları arasında toplanan veriler analiz edilerek köy adlarının değiştirilmesinin istatistiksel değerlendirmesi yapılmıştır. Bulgular, Uygur Türkçesindeki köy adlarının Çince isimlerle değiştirilmesinin dilsel asimilasyon, sosyal ve psikolojik baskılar ve kültürel kimlik erozyonu gibi çeşitli olumsuz etkiler yarattığını göstermektedir.
Analisis Kesesuaian Kawasan Wisata Hutan Mangrove Berbasis Ekowisata di Desa Sanleko Kabupaten Buru
Authors: Suneth Kasmin , Berhitu Pieter Th. , Botanri Adnan Affan Akbar
Published: October 2024

Sanleko Village is one of the villages in Namlea District, Buru Regency, Sanleko Village has mangrove potential on its coastline covering an area of 16.21 Ha. Judging from the current tourism conditions in the field, it is very minimal in terms of the development of tourism activities. The role of the community in the development of tourism has not been maximized from the access to bridges in mangroves that have been broken and potholes, the lack of facilities and infrastructure to support tourism. This study aims to determine the suitability of ecotourism-based mangrove forest tourism areas in Sanleko Village, Buru Regency. This study uses descriptive analysis methods and regional suitability analysis. The result obtained is that the conditions for mangrove forest tourism in Sanleko Village have beauty in the mangrove forest, in addition to that in front of the mangrove tourism there is a long sand beach. However, facilities and infrastructure such as roads made of wood and bamboo as bridges in mangrove tourism are not suitable for use. The total score results showed that the IKW values at observation stations 1.2, and 3 were 81.16%, 81.16% and 73.91%, respectively, and belonged to the S1 category (Very Appropriate). Which means that Sanleko Village mangrove tourism can be developed as Mangrove Ecotourism
Analisis Zink Pirition dalam Sampo Anti Ketombe secara Kromatografi Cair Kinerja Tinggi untuk Mendukung Pengawasan Pre-Market dan Post-Market
Authors: Zahara Zahara , Kurniawati Farida , Lusianti Erita
Published: October 2024

ZnPtO merupakan senyawa aktif dalam produk sampo anti ketombe. Meskipun memiliki banyak kegunaan, namun beberapa artikel ilmiah menyebutkan adanya dampak penggunaan senyawa ini baik terhadap lingkungan maupun terhadap hewan uji. Sebagai zat aktif dalam produk anti ketombe, Indonesia melalui Badan Pengawas Obat dan Makanan (BPOM) telah mengatur batas aman kandungan ZnPtO maksimal sebesar 2,0% dalam produk sediaan rambut bilas. Penelitian ini dilakukan untuk mengembangkan metode analisis yang akurat dan handal untuk menguji kandungan senyawa ZnPtO di dalam produk sampo anti ketombe. ZnPtO dapat dianalisis menggunakan instrumen Kromatografi Cair Kinerja Tinggi (KCKT) menggunakan detektor Photo Diode Array (PDA) pada panjang gelombang 275,9 nm dengan kolom C18 (250 x 4,6 mm dengan ukuran partikel 5 μm) menggunakan fase gerak asetonitril dan campuran larutan larutan kalium dihidrogen fosfat – dinatrium EDTA pH 4,0 (30:70). Suhu kolom dijaga pada 40oC dan laju alir 1,0 ml/menit. Hasil analisis menunjukkan baku ZnPtO terdeteksi pada waktu retensi sekitar 7 menit. Nilai koefisien korelasi (r) dan deviasi residual (Vx0) pada penetapan linieritas metode berturut-turut adalah 0,999% dan 0,65%. Presisi metode pada konsentrasi 20; 100; dan 160 μg/ml berturut – turut adalah 0,6694%; 0,4511% dan 0,4728%. Akurasi metode pada tiga konsentrasi tersebut berada pada rentang 98,3 – 100,9%. Seluruh parameter validasi telah memenuhi syarat. Hasil uji kadar ZnPtO dalam sampel sampo anti ketombe yaitu 0,0081%, 0,0040% dan 0,016%. Metode analisis yang dikembangkan terbukti selektif, akurat dan andal, sehingga dapat digunakan sebagai metode uji dalam rangka kontrol kualitas dan keamanan sebelum dan selama produk beredar.
Harmonisasi Metode Analisis Pengujian Cemaran 1,4-Dioksan dalam Kosmetik sebagai Upaya Memperkuat Pengawasan Pre-Market Melalui Jejaring Laboratorium Kosmetik di Indonesia
Authors: Arpan Susan Gracia , Sri Purwaningsih  , Hasti Kusuma  , Lusianti Erita , Yustina Yustina
Published: October 2024

Laboratorium mempunyai peranan yang sangat strategis dalam melindungi kesehatan masyarakat dengan menjamin mutu dan keamanan obat dan  makanan, termasuk kosmetikyang beredar di masyarakat. Pusat Pengembangan Pengujian Obat dan Makanan Nasional (PPPOMN) sebagai laboratorium pusat Badan Pengawas Obat dan Makanan (BPOM) terus mengembangkan metode analisis (MA) pengujian kosmetika yang handal, selektif, sensitif dan akurat seiring dengan perkembangan teknologi formulasi kosmetik. Namun, hingga saat ini laboratorium kosmetik, baik di Badan POM maupun laboratorium eksternal masih dihadapkan pada keterbatasan sumber daya manusia maupun sarana dan prasarana dalam melakukan pengembangan MA dan pengujian sampel produk kosmetik yang beredar. Untuk itu diperlukan perkuatan laboratorium pengujian kosmetikantara lain melalui jejaring dengan melibatkan stakeholder terkait. Saat ini jejaring laboratorium pengujian kosmetik yang sudah diikuti oleh Indonesia secara aktif adalah ASEAN Cosmetic Testing Laboratories Committee (ACTLC) dan Jejaring Laboratorium Kosmetik Indonesia (JLKI). Salah satu peran Indonesia di ACTLC dalam hal ini didelegasikan kepada PPPOMN adalah menjadi negara yang bertanggung jawab dalam pengembangan MA cemaran 1,4-Dioksan dalam kosmetik menjadi ASEAN Cosmetic Method (ACM) yang baru. Saat ini PPPOMN dan BSN serta Kementerian dan Laboratorium Eksternal yang tergabung dalam JLKI sedang berproses melakukan harmonisasi MA 1,4-Dioksan pada tingkat nasional berupa penerbitan Standar Nasional Indonesia (SNI). Dengan adanya SNI dan ACM ini seluruh laboratorium memiliki metode analisis standar untuk menjamin keamanan dan mutu produk kosmetik yang beredar serta meningkatkan daya saing produk bangsa. Penelitian ini dilakukan untuk mempelajari  metode penguatan pengawasan pre market kosmetik oleh industri dan laboratorium eksternal melalui harmonisasi MA 1,4 Dioksan di tingkat nasional maupun regional ASEAN.. Penelitian ini disusun dengan menggunakan pendekatan metode kualitatif berdasarkan data internal BPOM maupun data stakeholder yang terkait regulasi dan kemampuan pengujian 1,4-Dioksan tingkat nasional maupun regional.
Validasi Metode Deteksi Shigella dalam Tablet Hisap Obat Kuasi
Authors: Herawati Desty , Aprianto Eko , Cahyaningsih Eni , Miftahurrohmah Nur
Published: October 2024

Tablet hisap obat kuasi yang digunakan untuk meredakan sakit tenggorokan harus memenuhi persyaratan keamanan dan mutu sesuai Peraturan Badan POM No. 7 Tahun 2023 tentang kriteria dan tata laksana registrasi obat kuasi, yang menetapkan bahwa sediaan oral obat kuasi harus bebas dari cemaran mikroba Shigella spp. Kontaminasi oleh bakteri Shigella dapat menyebabkan penyakit seperti shigellosis yang ditandai dengan gejala seperti diare, muntah, dan demam. Penelitian ini bertujuan untuk memvalidasi metode deteksi Shigella spp. pada tablet hisap obat kuasi menggunakan metode acuan WHO (Quality Control Methods for Herbal Materials). Validasi dilakukan untuk memastikan metode ini dapat digunakan untuk analisis rutin di laboratorium BPOM. Pedoman yang digunakan untuk memvalidasi metode mikrobiologi adalah Singapore Accreditation Council (SAC) Guidance Notes C&B AND ENV 002 Tahun 2019 serta farmakope. Hasil penelitian menunjukkan bahwa metode WHO (Quality Control Methods for Herbal Materials) dalam mendeteksi Shigella sp. memiliki sensitivitas dan spesifisitas sebesar 100%, dengan tingkat positif palsu dan negatif palsu masing-masing 0%. Limit deteksi yang diperoleh adalah 3 cfu/g, yang memenuhi persyaratan (di bawah 10 cfu/g). Dari uji kesesuaian metode (optimasi) yang dilakukan menunjukkan bahwa pelarut awal yang digunakan untuk homogenisasi sampel pada deteksi Shigella cukup menggunakan Tryptone Soya Broth (1:10) tanpa perlu prosedur penetralan atau modifikasi tambahan pada tahapan homogenisasi sampel. Berdasarkan hasil ini, metode deteksi Shigella spp. menggunakan metode acuan WHO (Quality Control Methods for Herbal Materials) dinyatakan akurat dan dapat diterapkan untuk analisis rutin pengujian cemaran mikroba di laboratorium-laboratorium Badan Pengawas Obat dan Makanan.
Does Technostress Moderate Between Intention to Use ICT and Innovative Behavior: Exploring Antecedents of Digital Mindset
Authors:   UCP Business School, University of Central Punjab, Lahore, Pakistan, Hamid Madiha
Published: October 2024

This study aims to identify the factors influencing innovative behavior and digital mindset in Pakistani software houses while also examining the moderating role of technostress and the mediating role of the intention to use ICT. Data was collected longitudinally from 320 IT professionals employed in software houses in Pakistan, utilizing incremental and entity theories. A structured questionnaire based on a Likert scale was used to gather data, which was then analyzed using Smart-PLS to ensure accuracy and reliability. The findings reveal that a digital mindset, characterized by disruptive, generative, exponential, and combinational thinking, significantly impacts innovative behavior. Furthermore, the study shows a substantial mediating effect of the intention to use ICT on the relationship between digital mindset and innovative behavior. Additionally, perceived technostress is found to have a significant moderating impact on the intention to use ICT and innovative behavior. This research empirically develops and tests an integrated model of technostress, illustrating how a digital mindset can promote innovative behavior. The study’s conclusions offer valuable insights for future research on employee behavior and technostress.
Application of AI in Turkish Sign Language Translation: A Case Study of its Use and Purpose
Authors: Celik Ozer , Reza Pinar
Published: October 2024

In Turkey, around 3 million people have hearing impairments, and the shift to digital platforms during the pandemic has worsened accessibility challenges as websites and apps often ignore their needs. Research shows that 50% of hearing-impaired individuals struggle to understand written text due to Turkish Sign Language being their first language, with Turkish serving as a second language. Differences in grammar between Turkish and Turkish Sign Language, along with a limited sign language vocabulary, further hinder comprehension. To solve this, we developed AI-powered sign language translation systems that allow people who are deaf or hard of hearing to access digital content in Turkish Sign Language. SignForDeaf's system translates text into sign language videos using Natural Language Processing (NLP) and generates seamless videos with smooth word transitions. Currently, this system supports Turkish Sign Language, with future plans to include other languages like Arabic, American, British, and Finnish Sign Language. The system was designed in collaboration with sign language experts to ensure accuracy and an inclusive development of a digital environment.
Tunisian Sign Language Recognition System of Static Two-Handed Asymmetrical Signs using Deep Transfer Learning
Authors: Daknou Emna , Hermessi Haithem , Tabbane Nabil
Published: October 2024

Deaf and Hard of Hearing people use Sign Languages in the interaction among themselves and among hearing people. The automatic recognition of Static Two-Handed Asymmetrical signs is a hard operation, since it involves the implementation of complex processing system for providing image perception. In this paper, we produce a dataset of 2000 images containing 12 Two-handed Asymmetrical Tunisian Signs and utilize transfer learning for automatic recognition, achieving 98.29 % Accuracy. The simulations prove that this best Accuracy value is yielded by the Xception model when combined with the Adagrad optimizer, which indicates that our approach achieves high results despite using a small Dataset.
Automatic Gesture-Based Arabic Sign Language Recognition: A Federated Learning Approach
Authors: Alzu'bi Ahmad , Al-Hadhrami Tawfik , Albashayreh Amjad , Bani Younis Lojin
Published: October 2024

Featuring machine learning algorithms for recognizing hand gesture patterns adjusted for individuals with disabilities is an expanding trend in assisted living. This paper addresses the challenge of interpreting the semantics of image-based hand gestures by introducing a federated deep learning architecture for Arabic sign language recognition. The proposed model manages distributed learning through a client-server paradigm, wherein several edge nodes collaborate to jointly learn the discriminative features of confidential data without breaching its privacy. This model will enable more accessibility for people with deafness or impairment using image gestures. The federated learning procedure is primarily based on the ResNet32 deep backbone and federated averaging mechanism. The experimental results show the effectiveness of the proposed FL model, achieving an accuracy of 98.30% with 33 seconds on average for each client in a single training round. This demonstrates its high capabilities in recognizing Arabic sign language and improving the communication experience for people with disabilities.
Translate Arabic Text to Arabic Gloss for Sign Language
Authors: Alghamdi Doaa , Alsulaiman Mansour , Alohali Yousef , A. Bencherif Mohamed , Algabri Mohammed , A. Mekhtiche Mohamed
Published: October 2024

Arabic Sign Language (ArSL) is a language used by the deaf community across Arab countries, but the lack of familiarity with ArSL among the hearing population often leads to social isolation for deaf individuals. The structural differences between ArSL and spoken Arabic pose significant challenges for machine translation. In this study, we enhance Arabic to ArSL gloss translation by employing data augmentation techniques, expanding the dataset from 600 to over 23,328 samples using sequence-to-sequence transformer models. Our approach achieved a substantial performance improvement, increasing the BLEU score from 11.1% in the baseline model to 52.72% on original test set. The best model achieved a BLEU score of 85.17% on augmented data test, underscoring the effectiveness of data augmentation in enhancing ArSL translation quality.
The Development of AI-Powered Automatic Video Sign Language Translation Systems
Authors: Celik Ozer , Avcioglu Ahmet
Published: October 2024

People who are deaf or hard of hearing often face challenges in fully understanding written subtitles in videos due to the differences between sign language and spoken language, each having unique grammar and structures. While many social media platforms provide automatic subtitles, they are often insufficient for accessibility. Sign language interpretation should be included to make video content fully accessible. Traditionally, adding sign language to videos involves a time-consuming process of recording and embedding separate translation videos, which must be redone with any changes to the original video. The plugin simplifies this process by dynamically translating updates directly from subtitle files, significantly reducing the time, effort, and cost involved. It allows seamless sign language support for any video without modifying the original content. The plugin integrates with video players, providing a user-controlled, customizable sign language window that can be activated, moved, resized, or turned off as desired.
Further discussion on regulations of the logistic services in Vietnam–and construction issues for logistics in Ca Mau province
Authors:   Banking University HCMC Ho Chi Minh City Vietnam−International University of Japan, Niigata, Japan, Ngoc Huy Dinh Tran , Anh Dung Pham ,   Faculty of Business and Management, Apollos University,Great Falls, MT, United States, Thanh Xuan Tran Thi ,   Faculty of Transport Economics, University of Transport Technology (UTT), Hà Nô. i, Vietnam, Nuong Le Ngoc ,   Department of Law and Economic Management, Thai Nguyen University of Economics and Business, Administration (TUEBA), Vietnam, Hung Nhan Pham ,   Political School of Ca Mau Province, Ca Mau, Vietnam, Trong Diep Nguyen ,   University of Law, Vietnam National University, Hanoi, Vietnam, Xuan Ha Nguyen ,   Vifon Corporation Vietnam – HCM University of Technology, Ho Chi Minh City, Vietnam
Published: October 2024

Purpose: This research paper aims to present discussion on regulations of the logistic services in Vietnam and a case study of logistics in Ca Mau province. By using the panel approach, our findings: As the role of logistics has been increasingly important and China is a big export partner of our country, in Ca Mau, according to the approved plan, Nam Can Seaport is a local general port (type II), including Nam Can ports on Cai Lon river for ships up to 5,000 tons and the study "Development of seaports for ships of up to 5,000 tons". large load capacity in the Hon Khoai island area in accordance with the needs and capacity of investors.
RESPONSABILIDADE CIVIL PELO ABANDONO AFETIVO
Authors: Queiroz Amanda Raynar Honorato , Iana Priscilla de Oliveira
Published: October 2024

Esse artigo tem como enfoque abordar o instituto da responsabilidade civil em face dos casos de abandono afetivo dos pais em desfavor dos filhos. O objetivo desse estudo compreendeu analisar o cabimento do pagamento de indenização nos casos de abandono afetivo em desfavor dos filhos diante da ausência de norma específica sobre esse fenômeno. Quanto ao método seguido para a confecção desse artigo, cumpre destacar que essa é uma pesquisa bibliográfica do tipo exploratória com a finalidade de explorar e compreender melhor a possibilidade de cobrança de indenização nos casos de abandono afetivo realizado pelos pais em desfavor de crianças e adolescentes. A abordagem desse estudo é qualitativa, haja vistas que o objetivo é compreender o fenômeno do abandono afetivo e refletir sobre a responsabilização dos pais sem quantificar esses fenômenos. Nos resultados observou-se que os autores, e a própria jurisprudência do STJ tem entendido ser não apenas cabível, como necessário o pagamento de indenização para os filhos em virtude do abandono afetivo dos pais. Concluindo que a indenização é uma forma de responsabilizar os pais por gerar danos psicológicos, emocionais e ausência de assistência material aos filhos quando eles mais precisaram.
ACESSIBILIDADE AO CUIDADO FARMACÊUTICO POR PESSOAS COM DEFICIÊNCIA AUDITIVA
Authors: Souza Juliana Pinheiro de , Marinho Jaqueline Luvisotto , Mendonça Reginaldo Teixeira
Published: October 2024

Realizou-se revisão integrativa da literatura, objetivando identificar dificultadores de acessibilidade das pessoas com deficiência auditiva ao cuidado farmacêutico, com a seguinte pergunta norteadora: Como tem sido a conduta dos farmacêuticos no atendimento às pessoas com deficiência auditiva e quais as dificuldades encontradas? Utilizou-se busca, com operadores booleanos e descritores em saúde: (surdez) AND (assistência farmacêutica) para a Biblioteca Virtual em Saúde, e para o Scielo: (surd*) OR (deficiência auditiva) AND (assistência farmacêutica) OR (farmac*), para os últimos 10 anos. No Google Acadêmico foi realizada busca simples nos últimos 5 anos. Ao todo foram obtidos 2.075 resultados, dos quais foram selecionados 9 textos completos na revisão. Existe escassez de publicações sobre a temática. A barreira comunicativa foi frequente. O despreparo do profissional para atender pessoas com deficiência auditiva resulta em prejuízo ao cuidado farmacêutico, levando a maior risco no uso de medicamentos e em carência de informações para o autocuidado.
Oncometabolites in pancreatic cancer: Strategies and its implications
Authors: Maiti Arunima , Mondal Susmita , Choudhury Sounetra , Bandopadhyay Arnab , Mukherjee Sanghamitra , Sikdar Nilabja
Published: October 2024

Pancreatic cancer (PanCa) is a catastrophic disease, being third lethal in both the genders around the globe. The possible reasons are extreme disease invasiveness, highly fibrotic and desmoplastic stroma, dearth of confirmatory diagnostic approaches and resistance to chemotherapeutics. This inimitable tumor microenvironment ( TME) or desmoplasia with excessive extracellular matrix accumulation, create an extremely hypovascular, hypoxic and nutrient-deficient zone inside the tumor. To survive, grow and proliferate in such tough TME, pancreatic tumor and stromal cells transform their metabolism. Transformed glucose, glutamine, fat, nucleotide metabolism and inter-metabolite communication between tumor and TME in synergism, impart therapy resistance, and immunosuppression in PanCa. Thus, a finer knowledge of altered metabolism would uncover its metabolic susceptibilities. These unique metabolic targets may help to device novel diagnostic/prognostic markers and therapeutic strategies for better management of PanCa. In this review, we sum up reshaped metabolic pathways in PanCa to formulate detection and remedial strategies of this devastating disease.