bluuebunny/crossref_metadata_2025 huggingface dataset:
Real world outcomes in patients with neuroendocrine tumor receiving peptide receptor radionucleotide therapy
Authors: Hentzen Stijn , Mehta Kathan , Al-Rajabi Raed Moh’d Taiseer , Saeed Anwaar , Baranda Joaquina Celebre , Williamson Stephen K. , Sun Weijing , Kasi Anup
Published: June 2023

Aim: 177Lu-Dotatate (Lu-177), a form of peptide receptor radionuclide therapy (PRRT), was approved by Food and Drug Administration (FDA) for the treatment of somatostatin-receptor-positive neuroendocrine tumors (NETs) in 2018. Clinical trials prior to the FDA approval of Lu-177 showed favorable outcomes but there is limited published real world outcomes data. This study aims to describe and analyze real world outcomes of patients with NET who received Lu-177.
Methods: After obtaining institutional review board approval, retrospective evaluation was performed to analyze the efficacy of Lu-177 for somatostatin receptor-positive gastro-entero-pancreatic NETs (GEP-NETs) patients at the University of Kansas Cancer Center between June 2018 and September 2021. This study aims to determine the response rate to the treatment of the entire cohort and subgroups.
Results: A total of 65 patients received Lu-177 of which 58 completed treatment. The 58 patients had a median age of 61.5 years, 24 females and 34 males, 86% Caucasian and 12% black. The origins of NETs were primarily small bowel (n = 24) and pancreatic (n = 14). Pathology showed grades 1 (n = 21), 2 (n = 25), and 3 (n = 4) and were primarily well-differentiated tumors (n = 4). Among the cohort, 52 patients had imaging to assess response with 14 (26.9%) patients with partial response (PR), 31 (59.6%) with stable disease (SD), and 7 (13.5%) with progressive disease (PD). In a subset analysis, patients with non-functional disease (n = 29) had higher rates of PR 42.3% (compared to 11.5%, P = 0.0147) and higher disease control rate of 96% (compared to 78%, P = 0.042) than patients with functional disease (n = 29). Patients with non-functional disease had a lower PD of 3.85% (compared to 23%, P = 0.0147) than those with functional disease.
Conclusions: This real world outcomes analysis of NETs treated with Lu-177 shows improved PR when compared to the initial clinical trials and is promising for patients. In addition, patients with non-functional tumors were found to have a statistically significant improved response rate which has not been described in the literature before. If these study findings are validated in a larger cohort they may guide patient selection for Lu-177 therapy in the future.
Tärähdyttävät sankarit New Yorkin maailmannäyttelyssä 1939 – Mieskuoro Finlandia Suomen maakuvan viestijänä
Authors: Tilli Inari
Published: June 2023

At the opening of the Finnish section of the New York World’s Fair on May 4, 1939, the Finlandia Male Chorus performed; the choir had been founded especially for the trip to North America, and in particular for performing at the New York World’s Fair. In addition to general coverage in the press, the choir’s travel plans, its preparations, and the trip itself were followed on many different radio broadcasts. What did Mieskuoro Finlandia want to tell about Finland at the New York World’s Fair in the spring of 1939? How was the choir founded, how did it work towards the goal of its journey, and what did it do afterwards? Answers to these questions are sought here especially through the concepts of cultural diplomacy and country image. According to the article, the Finlandia Male Chorus’ activities serve as a good example of the creation of a country’s image implemented through the means of cultural diplomacy, which also includes cultural propaganda, i.e. the promotion of a country using its culture as a tool. The methodological approach of the article is situated in the cultural and historical research field of music.
Choral music and identities in Tanzania
Authors: Lampinen Leena
Published: June 2023

In her doctoral research, Lampinen explored the connection between choral repertoiresand identities within church choirs in one Lutheran Diocese in Northern Tanzania. The participantsin this research were a group of choir conductors in this diocese. The concept ofidentities was approached from individual, social, and group aspects as well as religious,ethnic, and national viewpoints.
Programa de mantenimiento de la lengua y cultura de origen del alumnado marroquí en España: diseño y validación de un instrumento
Authors: El Morabet Mohamed , Zaafour Abderrazak , Villaescusa García Carlos , Navarro-Granados María
Published: June 2023

El presente artículo tiene como objetivo presentar los resultados del diseño y validación teórica y empírica de un instrumento que permite efectuar una evaluación diagnóstica inicial del programa de Lengua Árabe y Cultura Marroquí (LACM) en España. Para ello, se aplicó el cuestionario a una muestra piloto, conformada por un total de setenta padres y madres de alumnado matriculado en el programa, concretamente, en las etapas de educación primaria y secundaria de las ciudades de Sevilla y Almería. Se calculó la consistencia interna a través del coeficiente Alpha de Cronbach, mostrando buenos índices de fiabilidad según los expertos. Para la validez de contenido se llevó a cabo un juicio de expertos y se analizó la confiabilidad o grado de acuerdo entre los mismos con el coeficiente Alpha de Krippendorff. La validez de constructo se efectuó a través de un Análisis Factorial Exploratorio y un Escalamiento Multidimensional No Métrico o PROXSCAL. Los resultados obtenidos sugieren que se trata de un instrumento eficaz para evaluar la opinión de las familias sobre el programa y el aprendizaje de la lengua árabe por parte de sus hijos e hijas
Time and visual-spatial illusions: Evidence for cross-dimensional interference between duration and illusory size
Authors: Bratzke Daniel , Peris Lena , Ulrich Rolf
Published: June 2023

Time and space are intimately related to each other. Previous evidence has shown that stimulus size can affect perceived duration even when size differences are illusory. In the present study, we investigated the effect of visual-spatial illusions on duration judgments in a temporal reproduction paradigm. Specifically, we induced the Ebbinghaus illusion (Exp. 1) and the horizontal-vertical illusion (Exp. 2) during the encoding phase of the target interval or the reproduction phase. The results showed (a) that illusory size affects temporal processing similarly to the way physical size does, (b) that the effect is independent of whether the illusion appeared during encoding or reproduction, and (c) that the interference between size and temporal processing is bidirectional. These results suggest a rather late locus of size-time interference in the processing stream.
Logging activities in the North: Assessing the impact on biodiversity conservation
Authors:   Institute of Socio-Economic and Energy Problems of the North, Komi Science Centre, Ural Branch of the Russian Academy of Sciences, Tikhonova Tatyana V.
Published: June 2023

In the context of sustainable forestry, biodiversity conservation assessment is a necessary element in asset and service accounting. Logging is an important driver of economic growth in the northern regions of Russia. The past twenty years have seen changes in timber harvesting technologies and forest management principles, which has led to an increase in research interest in identifying ecosystem responses in terms of biodiversity conservation. This study aims to assess changes in biodiversity within the active forest management territory of the Komi Republic, encompassing ten municipal districts and 24 forestry areas. The objectives of the study include evaluating the impact of factors such as population density, road network, and intact area on biodiversity preservation. Statistical analysis methods were utilized to assess the biodiversity status, focusing on the number of rare species threatened by logging. The analysis studied changes in species abundance, territorial distribution across forestry areas, and changes in their conservation status. Using statistical and factor analysis methods, the study identified the impact of forestry and anthropogenic factors on the conservation of species. The novelty of the research consists in identifying the stability degree of ecosystems by analyzing the state of large areas that have experienced long-term anthropogenic impacts on the Komi Republic territory. Most forests within the active forest management zone demonstrated favorable ecosystem conditions, with logging activities causing lichen disappearance and reduced fish numbers only in individual small areas. The anthropogenic impact had minimal influence on the number of rare species due to low population and road network density. Large areas of undisturbed forests contribute to the natural preservation of biodiversity, but their significant reduction in the southern area causes a threat to the existence of rare species. The greatest impact on the change in biodiversity on the territories affected by active forest management is caused by factors such as the level of territorial exploration, the preservation of undisturbed forests, and selective logging. The practical significance of this study lies in the potential application of the proposed algorithm by large Russian forest businesses when conducting their operations.
Big data analysis as a tool for analyzing the market of reindeer products made in the North of Russia
Authors:   Northern (Arctic) Federal University named after M. V. Lomonosov, Bogdanova Elena N. ,   National Research Tomsk State University, Ivanova Medeya V. ,   Luzin Institute for Economic Studies of the Kola Science Centre of the Russian Academy of Sciences, Simashko Tatiana V. ,   Northern (Arctic) Federal University named after M. V. Lomonosov
Published: June 2023

Reindeer products have become an integral element of the culture of indigenous peoples in the Arctic region, playing a significant role in human adaptation to extreme climatic conditions. This study investigated the online sales offerings of reindeer products to identify the Far North regions in Russia that most actively use information and communication technologies to promote their products in the domestic regional and interregional markets. It also aimed to analyze the range of traditional Arctic food products. The research methodology drew on the theoretical approaches of the spatial economics by A. G. Granberg and the free trade theory by P. R. Krugman. Methods for analyzing big data based on social media data mining were applied. The study utilized messages on the Internet related to the sale of reindeer products in Russia’s Far North regions in 2021–2022. The novelty of this study lies in the implementation of big data collection and analysis methods. It required adapting the PolyAnalyst platform to the needs of a specific research field and improving the analysis methodology. The analysis of online sales offerings revealed the most active Arctic regions: the Murmansk region, the Yamalo-Nenets Autonomous Okrug, the Komi Republic, and the Chukotka Autonomous Okrug. The growing interest in the Arctic has contributed to the formation of a wide range of ready-made dishes and venison processing methods, also becoming a catalyst for growth in Arctic food tourism. This creates important conditions for the economic growth of rural Arctic territories. Online platforms expand opportunities for Arctic ethnic entrepreneurship by overcoming the relative isolation of Arctic economic systems and providing a venue for selling products on the Internet. Consequently, future research prospects involve using big data analysis of the reindeer husbandry market to develop measures for managing the sales of reindeer products.
Izzagardiner and others: about the first scientific biography of the historian D.N. Alshits
Authors: Мауль В.Я.
Published: June 2023

В статье рассматривается анализ исторических, литературных и общественно-политических взглядов Д. Н. Альшица, предпринятый в монографии Н. А. Мининкова. Показано, как под пером автора перед читателем предстает незаурядная личность неравнодушного гражданина, видного историка и яркого литературного критика и драматурга.

The article reviews the analysis of the historical, literary and socio-political views of D.N. Alshits, undertaken in the monograph by N.A. Mininkov. It shows that the researcher has succeeded in presenting to the reader the outstanding personality of a caring citizen, a prominent historian, and a bright literary critic and playwright.
Estado del Arte de la Blockchain y su Aplicación a la Cadena de Suministros de las Plataformas Petroleras en la Región de Campeche
Authors: Martínez González Samuel , Pérez Rejón José Ángel , Herrera Sánchez Beatriz , Gómez Ramón Rubí del Carmen
Published: June 2023

Los responsables involucrados en la gestión de la cadena de suministro se enfrentan día con día a diferentes retos a lo largo de toda la cadena de suministro, su impacto ambiental y vulnerabilidad se han convertido en importantes fuentes de preocupación. Además, su tarea se vuelve cada vez más compleja a medida que se expande la actividad económica mundial. Para hacer frente a estos cambios y con ello responder de manera inmediata, las industrias se han visto obligadas a cambiar su paradigma tecnológico. En este sentido, una de las tecnologías que están emergiendo y que ha tomado gran relevancia en las cadenas de suministro es la Tecnología Blockchain. Por lo tanto, el presente trabajo se centra en analizar el estado del arte de dicha tecnología y en dar a conocer las potenciales aplicaciones que la Blockchain puede ofrecer a la Cadena de Suministros de las Plataformas Petroleras en la Región de Campeche. Para ello, se explicará en que consiste esta tecnología y su funcionamiento, se incluyen sus términos y características más relevantes. La presente investigación es de tipo documental, el método de trabajo consistió en una revisión amplia del estado del arte respecto a la Tecnología Blockchain. Finalmente, se concluye que utilizar la Tecnología Blockchain en la Cadena de Suministro de las Plataformas Petroleras en la Región de Campeche, representa un gran salto en las empresas de dicha región, como actualmente las conocemos, debido a que asegura la calidad de la información, a través del principio de inmutabilidad de datos, así como también la eliminación de intermediarios al momento de realizar transacciones bancarias.
HOMOFOBIA NA PERSPECTIVA DE ESTUDANTES, PROFESSORES E FUNCIONÁRIOS DE UMA ESCOLA PÚBLICA DE MACEIÓ - AL
Authors: Siqueira Kleber Saldanha de
Published: June 2023

Nas últimas décadas acentuaram-se as discussões acerca do combate à discriminação no seio social, principalmente aquelas voltadas ao gênero e à diversidade. No campo acadêmico, muitas questões são defendidas no contexto das Ciências Sociais com o objetivo de descrever e legitimar de forma científica os mecanismos que levam ao preconceito e à violência de gênero, seja ela de forma explícita ou implícita nos vários segmentos funcionais da sociedade. Diante dessa realidade, este artigo busca analisar as principais questões impactantes na vida dos estudantes do Ensino Médio sob o prisma das questões de gênero e diversidade com ênfase no convívio escolar, destacando como a intolerância configurada na homofobia pode ser a gênese responsável pelos diversos problemas enfrentados por estes estudantes ao longo do trajeto escolar. Ao mesmo tempo, buscamos refletir e reforçar, por meio dos resultados descritos, como a Educação em Direitos Humanos pode ser introjetada no universo da educação, de forma a ressignificar condutas e hábitos, muitas vezes nocivos que violam as diferentes manifestações de gênero dos indivíduos.
ABANDONADO, POR QUÊ?: DISCUSSÃO DE USOS E DESUSOS DE ÁREAS ANTIGAS EM ESTADO DE ABANDONO, COM FOCO NAS ESTAÇÕES FERROVIÁRIAS.
Authors: Carvalho Gabriel Lincoln Lopes
Published: June 2023

Os centros históricos exercem/exerceram papéis essenciais como núcleo de origem e desenvolvimento das cidades, estes espaços são palcos de transformações sociais e morfológicas de um município, além de perpassarem a identidade da sociedade e de sua cultura. Atualmente muitas áreas históricas encontram-se em estado de abandono ou em ruínas, sendo alarmante o fato de ter berços históricos e espaços essenciais na construção da cidade e de sua memória coletiva e individual, se tornar espaços invisíveis para a sociedade e gestão. Este trabalho discute sobre os processos e tipos de abandonos envolvendo áreas antigas, enfatizando a essencialidade da sua conservação e adequação de usos. Tem como objetivo principal discutir sobre a importância e o papel estruturador de áreas com valor histórico para a cidade, como também debater sobre os aspectos histórico-conceituais que caracterizam e favorecem o abandono de patrimônios de áreas históricas, utilizando como objeto de estudo as estações ferroviárias. Foi feita uma revisão bibliográfica para a obtenção dos dados necessários para panorama construído e discutido. Obteve como resultado uma construção cronológica e debruçada sobre áreas antigas e seus estados de abandono, como também as nuances e características envolvidas neste processo.
CAMELÓDROMOS: CONSIDERAÇÕES SOBRE A TIPOLOGIA ARQUITETÔNICA
Authors: Lima Pablo Corrêa , Braida Frederico
Published: June 2023

O comércio surgiu nas ruas através das feiras e bazares, porém, com o passar dos séculos, para atender as demandas sociais, surgiram os edifícios para abrigar diferentes tipologias comerciais. Até mesmo o comércio popular, que abrange certas relações intrínsecas com as ruas, passou a ser direcionado para dentro de edificações conhecidas como camelódromos. Objetivo: identificar as principais características tipológicas e espaciais de camelódromos construídos em algumas capitais brasileiras, contribuindo para a discussão dessa tipologia arquitetônica. Métodos: através da revisão de literatura, foram selecionadas três capitais brasileiras que construíram camelódromos entre 1990 e 2015; em seguida, procedeu-se uma análise comparativa, abrangendo as características de concepção, premissas arquitetônicas e sua infraestrutura em geral. Resultados: O camelódromo surgiu no Brasil na década de 1980 na tentativa de as cidades solucionarem os conflitos urbanos e de [re]organizarem seus centros. Foram analisados os camelódromos de Belo Horizonte (Shopping Oiapoque), Cuiabá (Shopping Popular) e Porto Alegre (POP Center), que foram importantes exemplos de tentativa de ordenamento do comércio popular nas cidades. Conclusão: A tipologia comercial apresenta características próximas às dos shopping centers, na medida em que vão assumindo uma estrutura de grande escala, abrigando não apenas a atividade dos comerciantes populares, mas também prestação de serviços, agências bancárias, praças de alimentação, grandes estacionamentos e equipamentos como elevadores e escadas rolantes, antes encontrados apenas em edifícios comerciais especializados em produtos mais sofisticados voltados às classes econômicas média e alta.
A POLIAFETIVIDADE COMO ENTIDADE FAMILIAR: DESMISTIFICAÇÃO
Authors: Stefanini Marília Rulli , Luca Guilherme Domingos de
Published: June 2023

No Brasil, o poliamor não é reconhecido legalmente como uma forma válida de relacionamento, donde o sistema jurídico brasileiro ainda é baseado no modelo tradicional de casamento monogâmico, no qual uma pessoa está legalmente casada com outra pessoa de cada vez. Isso significa que, do ponto de vista legal, a prática do poliamor não é reconhecida e não possui proteções ou direitos específicos garantidos pelo Estado. Em termos de direito de família, por exemplo, as leis brasileiras não reconhecem a possibilidade de um casamento ou união estável entre mais de duas pessoas, o que pode trazer influências legais para pessoas envolvidas em relacionamentos poliamorosos, como, por exemplo, não há possibilidade de um contrato de união estável entre três ou mais pessoas, nem de um regime de comunhão de bens que cubra todos os parceiros. Além disso, em caso de separação ou falecimento de um dos parceiros, não há reconhecimento legal para divisão de bens ou direitos de herança entre os demais. Assim sendo, o presente trabalho se justifica pela necessidade de desmistificação do instituto em razão dos imbróglios resultantes de sua existência fática, mas não jurídico. Para tanto, utilizou-se no presente capítulo de livro a base metodológica a partir do emprego do método dedutivo, bem como pesquisas em acerco bibliográfico e documental.
A JUSTIÇA RESTAURATIVA NA PERSPECTIVA DA FILOSOFIA
Authors: Aparecido De Almeida Flávio
Published: June 2023

Muitas são as críticas envolvendo o atual sistema de Justiça Criminal brasileiro, o que acabou por ensejar na criação de novas propostas visando a resolução de embates e conflitos, dentre estes, é possível destacar a Justiça Restaurativa. O procedimento restaurativo tende a colocar o ofensor, vítima e comunidade como protagonistas no processo de reestabelecimento da ordem e paz abaloados pelo descumprimento da lei. Tal contexto acarretou a reanálise do conceito de Justiça aplicado na atualidade visando a identificação de um novo modelo que tenha mais proximidade com a práxis e a atos justos construídos e legitimados como hábitos da sociedade. Este trabalho teve como objetivo geral analisar a Justiça Restaurativa como um mecanismo modificador, capaz de transformar as percepções e práticas que compõem o direito, contrapondo a visão de justiça pautada na punição e retribuição. O desenvolvimento deste estudo baseou-se em uma pesquisa bibliográfica, tendo sido desenvolvido por meio uma revisão literária qualitativa em revistas, periódicos e artigos selecionados através de buscas em sites de bancos de dados e livros.
A NARRAÇÃO IMPOSSÍVEL DE FRANZ KAFKA
Authors: Costa Ana Carolina Martins
Published: June 2023

O objetivo deste trabalho é analisar a produção literária do escritor judeu-tcheco Franz Kafka (1883-1924) tendo como fio condutor da análise o conceito de narração proposto pelo filósofo e crítico Walter Benjamin (1892-1940). Iniciaremos a discussão contemplando o problema da teoria narrativa desenvolvido por Benjamin para que, posteriormente, possamos analisar sua relação com os escritos kafkianos. Em seus textos “Experiência e Pobreza” (1933) e “O narrador” (1936), Benjamin expõe os paradoxos de uma desorientação moderna que culminou no declínio da experiência (Erfahrung) e no esfacelamento da narração tradicional. No entanto, a enunciação da morte da narração/narrativa não se inscreve em um tom nostálgico através da busca por uma harmonia perdida ou como denúncia de uma época decadente em suas formas de comunicação, mas, antes de tudo, se afirma pela necessidade do surgimento de uma nova (im)possibilidade de narrar. Enquanto uma construção literária que encara a perda de experiência como uma aporia necessária, a estética da obra kafkiana assume essa impossibilidade e faz dela sua condição e fundamento.
DIFERENCIADAS NOS MODELOS DE LIDERAR: NARRATIVAS DE VIDA DE MULHERES E SEUS MODELOS DE GESTÃO E LIDERANÇA
Authors: Sampaio Raimundo Nonato Carneiro , Fernandes Rivalina Maria Macêdo , Calou Antonio Leonardo Figueiredo
Published: June 2023

Notória é a disparidade entre homens e mulheres em relação às questões de igualdade de gênero, tendo vista que as mulheres enfrentam cotidianamente uma grande luta em busca de reconhecimento e participação justa e igualitária no ambiente de gestão organizacional. Diante desse fato que se acomete historicamente, este artigo tem como objetivo analisar os modelos de gestão e lideranças que são traçados e constituídos por mulheres se estabelecendo como estratégias de resistências ao modelo masculino que se impõe. Trata-se de uma pesquisa exploratória-analítica com abordagem qualitativa. Para atender o objetivo, foi utilizado como metodologia as narrativas biográficas de mulheres, enfatizando suas vivências na ocupação da gestão e a liderança de grandes organizações no Brasil. Como instrumentos para coleta de dados, foram usados materiais audiovisuais encontrados em plataformas virtuais. Ao se fazer a análise dos principais pontos das falas dessas mulheres sobre a temática de gestão e liderança feminina, observa-se que o objetivo foi alcançado, na medida em que as três gestoras em suas respectivas entrevistas mencionam princípios e métodos utilizados ou explicados por elas como sendo formas de mitigar as barreiras postas sobre a liderança feminina, o que possibilitou um ambiente mais igualitário e com uma diversidade de pessoas.
RELATO DE EXPERIÊNCIA: AS MÚLTIPLAS FACETAS DA FUNÇÃO DOS GESTORES EDUCACIONAIS
Authors: Silva Francisco Aderlan Ferreira da , Tamiarana Antonia Erisdalva C. , Bezerra Michella Daustria de Queiroz , Frazão Samara Sales
Published: June 2023

Este artigo tem como objetivo relatar experiências vivenciadas na gestão das escolas municipais de Maracanaú, no estado do Ceará, Brasil. O estudo se justifica pela relevância em estabelecer um diálogo entre aqueles que desejam assumir posições de gestores educacionais ou que abraçaram a missão de gerir uma escola por variados motivos. O objetivo primordial deste relato é fomentar a reflexão acerca desses dilemas enfrentados pelos líderes escolares e demais partes interessadas, bem como enganá-los em discussões sobre possíveis soluções para tais problemas. Ademais, visa-se fornecer instrumentos para lidar com situações análogas encontradas em suas respectivas instituições de ensino, apresentando uma série de situações a serem analisadas, comparadas, contrastadas, estudadas e discutidas por aqueles que desejam incorporar essa nova abordagem no campo da educação e liderar uma instituição educacional.
A LIDERANÇA NA PROMOÇÃO DE UMA CULTURA DE EFICIÊNCIA DA ORGANIZAÇÃO EDUCATIVA
Authors: Neves S.
Published: June 2023

A reflexão que se procurará desenvolver neste texto, nasceu da tentativa de resposta às seguintes questões: A liderança em contexto escolar é diferente da liderança em contextos empresariais? Há uma cultura de avaliação do desempenho organizacional das organizações educativas?No pressuposto de que a ação do diretor escolar e a sua liderança são fortemente indutores e estimuladores de climas e ambientes organizacionais que favorecem a organizaçãoescolar e o seu bom desempenho, a liderança escolar ganhou prioridade na esfera das políticas públicas de educação pelo papel que lhe é atribuído no desenvolvimento da escola ao considerar-se a sua forte influência nas motivações e capacitação dos professores e de outros atores escolares, nos contextos e ambientes escolares.
Sensory activities as part of a cultural tourism route for the Festival de Artes Vivas de la Ciudad de Loja (Living Arts Festival of the City of Loja)
Authors: Suárez-Jaramillo Gladys Alexandra , Ortega-Barba Grace Melina , Briceño Luzuriaga Yesenia Alexandra
Published: June 2023

This work was carried out with the objective of elaborating a proposal for a sensory tourism route of art and culture for the FIAVL, based on a selection of attractions under specific criteria of: availability, accessibility, safety, in addition to their relationship with the senses and how these senses are perceived in an attraction by the tourist; this is how the attractions that will act as the basis of this route were chosen. Based on these, together with the bibliographic review and the visitor's opinion or demand, the sensory tourism activities were defined; the second important factor for the route.  With these two factors, we proceeded to design the "Sensory Route: Feel Loja", a cultural tourism route that involves the five senses: sight, touch, smell, taste and hearing. The attractions are related to activities that stimulate these senses, and at the same time allow the visitor to learn more about the history and culture of the city of Loja. The methodology proposed for this research work was of the exploratory type, since no route of this type has been carried out in the city, and it also has a quantitative and qualitative approach. Bibliographic consultations were carried out, survey of tourist attractions: data sheet adapted to the methodology of the MINTUR and technical data sheets of the INPC, data collection through survey technique and Focus Group, among others.
O princípio da solidariedade e a legitimação da responsabilidade civil objetiva
Authors: Teixeira Neto Felipe
Published: June 2023

O presente artigo trata da verificação da existência de um fundamento comum de legitimação das várias hipóteses de responsabilidade civil objetiva. Parte, para tanto, de julgamento paradigmático realizado pelo Supremo Tribunal Federal, que identificou no princípio da solidariedade o responsável por esta função legitimadora. Analisa, a partir disso, a fragmentariedade que marca o referido regime de imputação de danos e as vicissitudes que disso decorem. Após uma revisão do conteúdo normativo do princípio da solidariedade, que segue devidamente situado na sua conformação hodierna, pretende explicar a forma como se apresenta apto a dar a legitimidade unificadora que a responsabilidade civil objetiva necessita.
Efficacy of Gemigliptin Add-on to Dapagliflozin and Metformin in Type 2 Diabetes Patients: A Randomized, Double-Blind, Placebo-Controlled Study (SOLUTION)
Authors: Lee Byung Wan , Min KyungWan , Hong Eun-Gyoung , Ku Bon Jeong , Kang Jun Goo , Chon Suk , Lee Won-Young , Park Mi Kyoung , Kim Jae Hyeon , Kim Sang Yong , Song Keeho , Yoo Soon Jib
Published: June 2023

Background: This study evaluated the efficacy and safety of add-on gemigliptin in patients with type 2 diabetes mellitus (T2DM) who had inadequate glycemic control with metformin and dapagliflozin.Methods: In this randomized, placebo-controlled, parallel-group, double-blind, phase III study, 315 patients were randomized to receive either gemigliptin 50 mg (n=159) or placebo (n=156) with metformin and dapagliflozin for 24 weeks. After the 24-week treatment, patients who received the placebo were switched to gemigliptin, and all patients were treated with gemigliptin for an additional 28 weeks.Results: The baseline characteristics were similar between the two groups, except for body mass index. At week 24, the least squares mean difference (standard error) in hemoglobin A1c (HbA1c) changes was –0.66% (0.07) with a 95% confidence interval of –0.80% to –0.52%, demonstrating superior HbA1c reduction in the gemigliptin group. After week 24, the HbA1c level significantly decreased in the placebo group as gemigliptin was administered, whereas the efficacy of HbA1c reduction was maintained up to week 52 in the gemigliptin group. The safety profiles were similar: the incidence rates of treatment-emergent adverse events up to week 24 were 27.67% and 29.22% in the gemigliptin and placebo groups, respectively. The safety profiles after week 24 were similar to those up to week 24 in both groups, and no new safety findings, including hypoglycemia, were noted.Conclusion: Add-on gemigliptin was well tolerated, providing comparable safety profiles and superior efficacy in glycemic control over placebo for long-term use in patients with T2DM who had poor glycemic control with metformin and dapagliflozin.
Superheavy Elements in Kilonovae
Authors: Holmbeck Erika M. , Barnes Jennifer , Lund Kelsey A. , Sprouse Trevor M. , McLaughlin G. C. , Mumpower Matthew R.
Published: June 2023

As LIGO-Virgo-KAGRA enters its fourth observing run, a new opportunity to search for electromagnetic counterparts of compact object mergers will also begin. The light curves and spectra from the first “kilonova” associated with a binary neutron star merger (NSM) suggests that these sites are hosts of the rapid neutron capture (“r”) process. However, it is unknown just how robust elemental production can be in mergers. Identifying signposts of the production of particular nuclei is critical for fully understanding merger-driven heavy-element synthesis. In this study, we investigate the properties of very neutron-rich nuclei for which superheavy elements (Z ≥ 104) can be produced in NSMs and whether they can similarly imprint a unique signature on kilonova light-curve evolution. A superheavy-element signature in kilonovae represents a route to establishing a lower limit on heavy-element production in NSMs as well as possibly being the first evidence of superheavy-element synthesis in nature. Favorable NSM conditions yield a mass fraction of superheavy elements X

Z≥104 ≈ 3 × 10−2 at 7.5 hr post-merger. With this mass fraction of superheavy elements, we find that the component of kilonova light curves possibly containing superheavy elements may appear similar to those arising from lanthanide-poor ejecta. Therefore, photometric characterizations of superheavy-element rich kilonova may possibly misidentify them as lanthanide-poor events.
Absent celiac trunk and unusual arterial anatomy of the upper abdomen: into the deep
Authors: Covantsev Serghei , Uzdenov Rasul , Mazuruc Natalia , Turovets Daria , Belic Olga
Published: June 2023

The celiac trunk is the first major branch of the abdominal aorta. It originates from the ventral aspect of the aorta at the level of T12–L1 vertebrae and was originally described as an artery that branches into the common hepatic artery, left gastric artery, and splenic artery. Absence of the celiac trunk and origin of the three arteries separately from the aorta is a rare entity that is reported in 0.38% to 2.6% of cases. It is even more uncommon that this variation can be accompanied by other vascular variations of the upper abdomen as accessory arteries to the liver, stomach, and pancreas. These cases arise during embryogenesis due to decreased arterial degeneration combined with decreased arterial fusion, which results in the anatomical variations present in the current case. Complex arterial variations are both a risk for iatrogenic injury during surgical procedures and beneficial during endovascular supply as they may provide additional access for embolization and chemotherapy.
Cases of acute hemiparesis in childhood
Authors: Panova Margarita , Pacheva Iliyana , Gaberova Katerina , Iordanova Ralitsa , Sotkova Iglica , Galabova Fani , Tartova Desislava , Dimitrova-Popova Diana , Ivanov Ivan
Published: June 2023

Introduction: Acute hemiparesis is an emergency of various etiologies and possible fatal outcome.

Aim: The aim of this study was to determine the etiology, clinical manifestations, and prognosis of acute hemiparesis in childhood.

Materials and methods: This is a retrospective study of 52 children (28 boys and 24 girls) aged 4 months to 16 yrs 11 months with acute hemiparesis, admitted to the Clinic of Pediatrics at St George University Hospital between 2013 and 2020. After clinical examination, a modern diagnostic and therapeutic approach was used.

Results: The identified causes of acute hemiparesis were ischemic stroke (21), postictal paresis after seizure (9), hemorrhagic stroke (6), venous sinus thrombosis (5), encephalitis (3), transient ischemic attacks (TIAs) (2), posterior reversible encephalopathy syndrome (PRES) (2), hemiplegic migraine (1), demyelinating CNS disease (1), ventriculoperitoneal shunt complication (1), glutaric aciduria type 1 (1), brain tumor (1), and CNS metastasis (1).

The most common manifestations associated with acute hemiparesis were impaired consciousness (27), involvement of cranial nerves – central (25) and peripheral (1) facial nerve palsy, abducens (1), ocolomotorius (1), hypoglossus (1) nerve palsy, seizures (25), raised intracranial pressure (18), speech disorders (15), signs of infection (14), headache (12), and hemibody sensory disturbances (9).

In 8 children (14%), the hemiparesis was permanent, in 2 recurrent, and in 7 (12%) fatal.

Conclusions: Unlike in adult patients, acute hemiparesis in children has many causes, which requires a large number of etiological studies. With a quick diagnosis and adequate treatment, recovery of function in children is more common than in adults – it is achieved in two thirds of children.
A hitherto overlooked article by Gressitt in 1941 (Insecta, Coleoptera, Cerambycidae, Lamiinae)
Authors: Lin Mei-Ying , Lingafelter Steven W.
Published: June 2023

An article published by Gressitt (1941) has been ignored by all longicornists, including Gressitt himself. However, according to ICZN, it meets all criteria as an official publication, and this status affects three taxa that were formally described therein: Bacchisa (Bacchisa) rigida (Gressitt, 1941) = Chreonoma rigida Gressitt, 1941 = Chreonoma rigida Gressitt, 1942 homonym and syn. nov.; Tetraophthalmus sikang (Gressitt, 1941) = Chreonoma sikang Gressitt, 1941 = Chreonoma sikanga Gressitt, 1942, syn. nov.; Anastathes parva hainana Gressitt, 1941 = Anastathes parva hainana Gressitt, 1942, homonym and syn. nov.
A new species of Otostigmus (Chilopoda, Scolopendromorpha, Scolopendridae) from China, with remarks on the phylogenetic relationships of Otostigmus politus Karsch, 1881
Authors: Chen Tian-Yun , Jiang Chao , Huang Lu-Qi
Published: June 2023

Through a combination of morphological and DNA data, a new scolopendrid centipede from southern and southwestern China was revealed: O. tricarinatussp. nov. The species belong to the politus group but has three sharp tergal keels. Validation of phylogenetic status was performed through molecular analysis of the cytochrome c oxidase subunit I (COI), 16S rRNA, and 28S rRNA sequences from 16 Otostigmus species. Otostigmus tricarinatussp. nov. was found to be two populations and varied in the number of spines on the ultimate prefemur, the sutures on a sternite, and a pore-free median longitudinal strip in the pore field. The Yunnan-Guizhou plateau population of O. tricarinatussp. nov. was sister to the clade O. politus politus + O. politus yunnanensis + Guangxi population of O. tricarinatussp. nov. with strong support from both BI (bayesian inference) and ML (maximum likelihood) analyses (PP = 1, BS = 97%).
Semi-separation axioms associated with the Alexandroff compactification of the $ MW $-topological plane
Authors: Lee Sik , Han Sang-Eon
Published: June 2023

The present paper aims to investigate some semi-separation axioms relating to the Alexandroff one point compactification (Alexandroff compactification, for short) of the digital plane with the Marcus-Wyse ($ MW $-, for brevity) topology. The Alexandroff compactification of the $ MW $-topological plane is called the infinite $ MW $-topological sphere up to homeomorphism. We first prove that under the $ MW $-topology on $ {\mathbb Z}^2 $ the connectedness of $ X(\subset {\mathbb Z}^2) $ with $ X^\sharp\geq 2 $ implies the semi-openness of $ X $. Besides, for the infinite $ MW $-topological sphere, we introduce a new condition for the hereditary property of the compactness of it. In addition, we investigate some conditions preserving the semi-openness or semi-closedness of a subset of the $ MW $-topological plane in the process of an Alexandroff compactification. Finally, we prove that the infinite $ MW $-topological sphere is a semi-regular space; thus, it is a semi-$ T_3 $-space because it is a semi-$ T_1 $-space. Hence we finally conclude that an Alexandroff compactification of the $ MW $-topological plane preserves the semi-$ T_3 $ separation axiom.
Induced 3-Hom-Lie superalgebras
Authors: Guan Baoling , Tian Xinxin , Tian Lijun
Published: June 2023

We construct 3-Hom-Lie superalgebras on a commutative Hom-superalgebra by means of involution and even degree derivation. We construct a representation of induced 3-Hom-Lie superalgebras by means of supertrace.
On the Fractal interpolation functions associated with Matkowski contractions
Authors: Attia Najmeddine , balegh Mohamed , Amami Rim , Amami Rimah
Published: June 2023

In this paper we investigate an iterated function system that defines a fractal interpolation function, where ordinate scaling, that is Lipschitz constant in Banach contraction principle is substituted by real-valued control function. In such a manner, fractal interpolation functions associated with Matkowski contractions are obtained and provide a new framework of approximating experimental data. Furthermore, given a data generating function $ f $, we study a new class of fractal interpolation functions which converge to $ f $.
Error estimate of L1-ADI scheme for two-dimensional multi-term time fractional diffusion equation
Authors: Li Kexin , Chen Hu , Xie Shusen
Published: June 2023

A two-dimensional multi-term time fractional diffusion equation $ {D}_{t}^{\mathit{\boldsymbol{\alpha}}} u(x, y, t)- \Delta u(x, y, t) = f(x, y, t) $ is considered in this paper, where $ {D}_{t}^{\mathit{\boldsymbol{\alpha}}} $ is the multi-term time Caputo fractional derivative. To solve the equation numerically, L1 discretisation to each fractional derivative is used on a graded temporal mesh, together with a standard finite difference method for the spatial derivatives on a uniform spatial mesh. We provide a rigorous stability and convergence analysis of a fully discrete L1-ADI scheme for solving the multi-term time fractional diffusion problem. Numerical results show that the error estimate is sharp.
Exploration of Interstellar Ice with JWST and the Origin of Life
Authors: LEE Jeong-Eun
Published: June 2023

The James Webb Space Telescope (JWST), equipped with the Near-Infrared Spectrograph (NIRSpec) and the Mid-Infrared Instrument (MIRI), offers a unique opportunity to investigate interstellar ice, which is composed of mixtures of water and various volatile molecules, such as methane, ammonia, carbon dioxide, and others. Interstellar ice serves as a crucial reservoir for organic compounds, including prebiotic building blocks. With its advanced spectrometers, the JWST enables detailed observations, identification of molecular signatures, and a deeper understanding of the formation and diversity of interstellar ice. These investigations contribute to astrobiology research and the quest to unravel the origins of life. The JWST’s NIRSpec and MIRI provide essential capabilities for advancing astrochemistry and our comprehension of cosmic origins.
Digital Assessment Literacy
Authors: Thai Thuy , Sheehan Susan , Nguyen Quynh Thi Ngoc , Nguyen Thao Thi Phuong , Nguyen Yen Thi Quynh , Tran Hien Thi Thu , Nguyen Chi Thi , Nguyen Hoa Quynh , Bui Sao
Published: June 2023

This chapter reports on a project explored which classroom-based English language assessment practices, with a particular emphasis on digital assessments, in Vietnam. A mixed-method approach to data collection was adopted to understand the current assessment landscape. The methods include questionnaire (N = 2569) and teaching observations with follow-up interviews (N =7). The results of the project revealed what were behind teachers' choices of assessment tasks in their classroom, the use of assessment feedback and the challenges faced by the teachers in their practices in online environment. The project has extended an understanding of the current assessment landscape in Vietnam. Discussions on how the data has informed an online toolkit which will provide assessment and testing resources and recommendation for best practices will be presented as effective assessment can support and promote learning, and as Crusan et al. point out it is the students who lose out if assessment practices are poor.
“We Don't Know What We Don't Know”
Authors: Mäkipää Toni , Soltyska Anna
Published: June 2023

This chapter studies post-pandemic assessment literacy and professional development related to assessment literacy for English teachers in Finland and Germany. The aim of the research is to determine the extent to which language instructors in both countries have been prepared for designing, performing, and evaluating assessment activities, particularly in remote teaching contexts. The study also explores available training options to enhance teachers' assessment literacy. The current study addresses teachers at all levels of education, including primary, secondary, tertiary, and vocational. Qualitative and quantitative data were collected through an online survey (N = 124) and structured video conference interviews (N = 27). The results indicate a significant gap in assessment literacy regarding online assessment (irrespective of the country of the participants, their age, or teaching experience). Furthermore, the results corroborate that there is ample demand for training in online assessment design and administration, suggesting the preferred modes and topics of such training.
Public Utility System Evolution
Authors: Vranjanac Žarko , Rađenović Žarko
Published: June 2023

The chapter provides an overview of the origin and development of the public utility system through different epochs in the development of human civilization. The old century is characterized by the emergence of significant architectural achievements related to the public utility system. The darkest period in the history of human civilization was the Middle Ages, in which there was stagnation in the development of the public utility system. In the new century, the process of planning in cities and equipping them with communal infrastructure all over the world begins. The modern public utility system is characterized by the application of the latest technologies, innovations, and knowledge to improve the quality of life of the population and the effects of environmental protection, which requires monitoring through the development of performance indicators. The methodological framework of this research is based on cluster analysis using Ward's method, where the selected countries will be grouped into clusters.
Sustainability Enhancement in Water Supply and Municipal Waste Management Utilities
Authors: Stanković Sandra , Petrović Natalija
Published: June 2023

The city is an invention of human civilization that is distinguished, among other things, by the presence of infrastructure systems that assist public utility management. Globally, there is a growing awareness of the vital role that water and waste management play in sustainable development. The sustainable management of utility systems is unquestionably in the public and state interest. Therefore, this chapter presents current good practices and general ideas that constitute a foundation for beginning sustainable water and municipal waste management efforts in any activity. It also discusses the fundamental ways of improving sustainability in the municipal waste and water supply management sectors.
Joint Actions in Water Resources Management in the Transboundary Ecologically Sensitive Area of the Prespa Lakes
Authors: Damianos Georgios
Published: June 2023

Transboundary lakes have always played a significant role in the development prospects and welfare of border areas. The international hydrological basin of the Prespa Lake, a protected area in three neighboring countries, Greece, Albania, and North Macedonia, is a typical example of a transboundary lake basin of exceptional importance. The empirical investigation of transboundary water management and sustainability cooperation in the Prespa, which adds to the limited international research in transboundary lakes, was carried out via six structured interviews, two per country, to identify the strengths and weaknesses as well as the opportunities and threats in the Prespa basin, and highlight the significance of transboundary cooperation towards sustainable development and social prosperity between riparian Municipalities. The results obtained have significant implications for all stakeholders in the Prespa basin, as they highlight the need to organize joint actions and generate new development strategies and products, such as alternative forms of tourism.