bluuebunny/crossref_metadata_2025 huggingface dataset:
ABCD1 gene mutation in an Italian family with X-linkedadrenoleukodystrophy: case series
Authors: Mohn Angelika , Polidori Nella , Aiello Chiara , Rizzo Cristiano , Giannini Cosimo , Chiarelli Francesco , Cappa Marco
Published: May 2021

Adrenoleukodystrophy is a peroxisomal X-linked recessive disease caused by mutations in the ABCD1 gene, located on the X-chromosome (Xq28). Gene mutations in patient with adrenoleukodystrophy induce metabolic alterations characterized by impaired peroxisomal beta-oxidation and accumulation of very long chain fatty acid (VLCFA) in plasma and in all tissues. Although nutritional intervention associated with a various mixture of oil prevents the accumulation of VLCFA, to date no causal treatment is available. Therefore, haematopoietic stem cell transplantation (HSCT) and gene therapy are allowed only for very early stages of cerebral forms diagnosed during childhood.We reported a case series describing five family members affected by X-linked adrenoleukodystrophy caused by a novel mutation of the ABCD1 gene. Particularly, three brothers were affected while the sister and mother carried the mutation of the ABCD1 gene. In this family, the disease was diagnosed at different ages and with different clinical pictures highlighting the wide range of phenotypes related to this novel mutation. In addition, these characteristics stress the relevant role of early diagnosis to properly set a patient-based follow-up.

Learning points

We report a novel mutation in the ABCD1 gene documented in a family group associated to an X-ALD possible Addison only phenotype.

All patients present just Addison disease but with different phenotypes despite the presence of the same mutations. Further follow-up is necessary to complete discuss the clinical development.

The diagnosis of ALD needs to be included in the differential diagnosis in all patients with idiopathic PAI through accurate evaluation of VLCFA concentrations and genetic confirmation testing.

Early diagnosis of neurological manifestation is important in order to refer timely to HSCT.

Further follow-up of these family members is necessary to characterize the final phenotype associated with this new mutation.
Hypertriglyceridemia-induced pancreatitis in pregnancy: case review on the role of therapeutic plasma exchange
Authors: Tan Sarah Ying Tse , Teh Swee Ping , Kaushik Manish , Yong Tze Tein , Durai Shivani , Tien Claudia Jong-Chie , Gardner Daphne Su-Lyn
Published: May 2021

Gestational hypertriglyceridemia-induced pancreatitis is associated with significant maternal and fetal morbidity and mortality. We report a case of gestational hypertriglyceridemia-induced pancreatitis in a primigravida at 31-weeks gestation, complicated by impending preterm labor and metabolic acidosis requiring hemodialysis. This was successfully managed with therapeutic plasma exchange (TPE), followed by i.v. insulin, low-fat diet, and omega-3. Triglyceride levels stabilized after TPE and the patient underwent an uncomplicated term delivery. In pregnancy, elevated estrogen and insulin resistance exacerbate hypertriglyceridemia. Management is challenging as risks and benefits of treatment options need to be weighed against fetal wellbeing. We discuss management options including a review of previous case reports detailing TPE use, dietary optimization, and delivery timing. This case emphasizes the importance of multidisciplinary care to optimize maternal and fetal outcomes.

Learning points

Gestational hypertriglyceridemia-induced pancreatitis has high morbidity.

A multidisciplinary team approach is a key as maternal and fetal needs must be addressed.

Rapid lowering of triglycerides is crucial and can be achieved successfully and safely with plasma exchange.

A low-fat diet while ensuring adequate nutrition in pregnancy is important.

Timing of delivery requires consideration of fetal maturity and risk of recurrent pancreatitis.
Recent progress in research and application of engineered implanted cells for biomedical applications
Authors: Chen Tianying , Zhang Xue , Wu Qiong
Published: May 2021

Background

The core concept of cell engineering is the use of synthetic biological methods to engineer and design genetically modified cells with specific functions, which has revolutionized the biotechnology industry and cell therapy. Implanted cells play an important role in the cell therapy, but the currently used implanted cells are unable to fully meet the needs of researchers and clinicians. Therefore, the construction of engineered implanted cells has become a new research area, with many groups exploring the working principles of implanted cells, allowing them to better exert their repair function.

Results

Based on the existing cell engineering platforms, this paper summarizes the main types of chassis cells used in implanted cell engineering, progress in the development of gene editing tools and delivery systems, as well as strategies for the construction of engineered implanted cells.

Conclusions

The rational use of synthetic biology methods to program and control the function of implanted cells with high spatiotemporal accuracy provides new ideas for the development of cell therapy, and opens up new possibilities for exploring the mechanism of implanted cell action to allow them to better exert their role in promoting the progress of repair.
Will the large‐scale vaccination succeed in containing the COVID‐19 pandemic and how soon?
Authors: Zhao Shilei , Sha Tong , Wu Chung‐I , Xue Yongbiao , Chen Hua
Published: May 2021

Background

The availability of vaccines provides a promising solution to contain the COVID‐19 pandemic. However, it remains unclear whether the large‐scale vaccination can succeed in containing the COVID‐19 pandemic and how soon. We developed an epidemiological model named SUVQC (Suceptible‐Unquarantined‐Vaccined‐Quarantined‐Confirmed) to quantitatively analyze and predict the epidemic dynamics of COVID‐19 under vaccination.

Methods

In addition to the impact of non‐pharmaceutical interventions (NPIs), our model explicitly parameterizes key factors related to vaccination, including the duration of immunity, vaccine efficacy, and daily vaccination rate etc. The model was applied to the daily reported numbers of confirmed cases of Israel and the USA to explore and predict trends under vaccination based on their current epidemic statuses and intervention measures. We further provided a formula for designing a practical vaccination strategy, which simultaneously considers the effects of the basic reproductive number of COVID‐19, intensity of NPIs, duration of immunological memory after vaccination, vaccine efficacy and daily vaccination rate.

Results

In Israel, 53.83% of the population is fully vaccinated, and under the current NPI intensity and vaccination scheme, the pandemic is predicted to end between May 14, 2021, and May 16, 2021, assuming immunity persists for 180 days to 365 days. If NPIs are not implemented after March 24, 2021, the pandemic will end later, between July 4, 2021, and August 26, 2021. For the USA, if we assume the current vaccination rate (0.268% per day) and intensity of NPIs, the pandemic will end between January 20, 2022, and October 19, 2024, assuming immunity persists for 180 days to 365 days. However, assuming immunity persists for 180 days and no NPIs are implemented, the pandemic will not end and instead reach an equilibrium state, with a proportion of the population remaining actively infected.

Conclusions

Overall, the daily vaccination rate should be decided according to vaccine efficacy and immunity duration to achieve herd immunity. In some situations, vaccination alone cannot stop the pandemic, and NPIs are necessary to supplement vaccination and accelerate the end of the pandemic. Considering that vaccine efficacy and duration of immunity may be reduced for new mutant strains, it is necessary to remain cautiously optimistic about the prospect of ending the pandemic under vaccination.
Necmettin Erbakan Üniversitesi Diş Hekimliği Fakültesi Periodontoloji Kliniğine Başvuran Hastalarda Periodontal Hastalık Farkındalığı
Authors: ÖZKAN ŞEN Dilek , UCAN YARKAC Fatma , ÖNCÜ Elif
Published: May 2021

Amaç: Bireyler genellikle mevcut periodontal hastalık durumlarının farkında değildirler ve periodontal hastalıklar tedavisi yapılmadığında diş kaybına neden olabilir. Bu çalışmanın amacı kliniğe başvuran hastaların periodontal hastalık durumları hakkında ne kadar bilgileri olduğunu değerlendirerek periodontal farkındalıklarını belirlemektir.
Gereç ve Yöntem: Çalışmaya 123 birey (70 kadın, 53 erkek) dahil edildi. Hastaların periodontal hastalık durumları, sondalamada kanama varlığı, dişeti çekilmesi, mobilite, plak indeksi, gingival indeksi ve sondalama cep derinliği ölçülerek değerlendirildi. Hastalara tedavi öncesi anket formu verilerek kendilerine ait bilgiler, sigara içme durumları, sistemik anamnez ve periodontal hastalık algılarıyla ilgili sorular sorularak cinsiyet, yaş, öğrenim durumu ve meslek bilgileri sorgulandı. Periodontal farkındalıkları verdikleri cevaplarla klinik durumları kıyaslanarak değerlendirildi.
Bulgular: Periodontal klinik parametreler her iki cinsiyette de benzerdi. Sosyoekonomik durum, diş mobilitesi varlığı ve sigara kullanımı değerlendirildiğinde kadın ve erkekler arasında anlamlı farklılık görüldü. Hastaların periodontal hastalık teşhisi ile bu bulgulara ait farkındalıkları değerlendirildiğinde, kadın ve erkekler arasında anlamlı farklılık görülmedi (p>0,05). İlaveten, gingivitisli ve periodontitisli bireyler arası periodontal farkındalığı açısından anlamlı farklılık vardı (p<0,05). Diş mobilitesi ile hastaların mobilite farkındalıkları arasında anlamlı bir farklılık bulunmadı (p>0,05). Dişeti çekilmesi ile hastaların dişeti çekilmesi farkındalıkları değerlendirildiğinde anlamlı farklılık görülmedi (p>0,05). Bireylerin kanama farkındalığı ve kanama eşiği arasında anlamlı bir farklılık yoktu (p>0,05).Eğitim seviyesi açısından cinsiyetler arasında anlamlı farklılık yoktu ve eğitim düzeyinin bireylerin periodontal farkındalıklarını etkilemediği görüldü (p>0,05) .
Sonuç: Çalışmamızın sonuçlarına göre kliniğimize başvuran bireylerin eğitim düzeylerinden bağımsız olarak düşük periodontal farkındalığa sahip olduklarını ve periodontal hastalığın semptomları ile periodontal hastalık ilişkisinin bireyler tarafından bilinmediği görülmüştür.
The Economics of the Name Change: Long-term Adjustments towards EU/NATO or Short-term Resolution of Political Uncertainty?
Authors: Srbinoski Bojan , Poposki Klime , Dencic-Mihajlov Ksenija , Pavlovic Milica
Published: May 2021

North Macedonia and Greece resolved the 27-year country name dispute and removed the main hurdle for North Macedonia to start the accession processes towards the EU and NATO. The paper analyzes the stock market movements around several events related to the name issue resolution to uncover whether Macedonian companies experienced stock price adjustments according to the long-term benefits/costs of joining the EU/NATO. The dynamics of the market reactions suggest that the investors reacted systematically to the short-term political uncertainty created around the referendum rather than to the long-term perspectives of the EU/NATO integration. We integrate the knowledge from the literature which explores stock market reactions to EU enlargement/exit and political elections and provide contributions for researchers and policymakers.
DISCURSO EN EL SENADO SOBRE LA FORMACIÓN DE LA UNIDAD POPULAR
Authors: Allende Salvador
Published: May 2021

DISCURSO EN EL SENADO SOBRE LA FORMACIÓN DE LA UNIDAD POPULAR
Problematic Internet use among residential college students during the COVID-19 lockdown: A social network analysis approach
Authors: Xia Yiwei , Fan Yanying , Liu Tzu-Hsuan , Ma Zhihao
Published: May 2021

Background and aims

During the COVID-19 lockdown, problematic Internet use (PIU) has become a serious issue among residential college students, who remain physically isolated from off-campus society. This study constructs an integrated model to investigate the influencing mechanisms of internal locus of control (LOC) and objective peer effects.

Methods

Residential college students (n = 494) were surveyed from a single department of a Chinese university. An item from the World Value Survey was employed to measure internal LOC, while objective peer effects were assessed via friends’ mutual nominations. Finally, PIU was measured using Young’s Internet Addiction Tests, while a social network analysis and logit regression were combined to estimate various factors’ effects on PIU.

Results

In our sample, the prevalence rate of PIU was 30.6%, and while internal LOC was a protective factor for PIU, its protective role was diluted when exposed to a peer environment with high PIU prevalence. Furthermore, indegree performed contrasting roles on PIU under various network conditions. It acted as a protective factor when exposed to a low prevalence of PIU in a peer environment; however, it became a risk factor when PIU peers were prevalent. Lastly, the protective efficacy of betweenness was activated when individuals had more than one PIU friend.

Discussion and conclusions

Further intervention studies focusing on individuals with a weak internal LOC are recommended during the lockdown. Additionally, interventions that consider the network structures carefully, may enhance the prevention of PIU.
Pastoral dairying in rural Mongolia
Authors: Reichhardt Björn
Published: May 2021

In this photo essay, I illustrate ethnographic encounters with dairying practices and dairy microbes in various regions of Mongolia. Drawing on fieldwork conducted during two consecutive summers this essay focuses on the sociocultural role of microbial starter cultures in producing diverse dairy products (such as fermented mare’s milk) and in cross-generational knowledge transfer. The Mongolian word for starter culture is khöröngö, which also means capital and heritage. In this context, a sociocultural anthropological approach sheds new light on starter cultures as mobile entities of value across space and time.
Relaciones entre memoria operativa, inteligencia, comprensión lectora y rendimiento académico en Historia en 4º de la Educación Secundaria
Authors: Jiménez-Cárdenas Jaime , Gómez-Veiga Isabel , García-Madruga Juan-A.
Published: May 2021

El propósito de este estudio es analizar las interrelaciones entre los procesos ejecutivos de la Memoria operativa (MO), la inteligencia fluida y la comprensión lectora, así como su capacidad predictiva respecto del rendimiento académico en Historia. Participaron 26 estudiantes de Educación Secundaria Obligatoria. Los resultados indican que las variables cognitivas correlacionan entre sí y con el rendimiento académico. Los análisis de regresión mostraron que la comprensión lectora es la variable cognitiva de alto nivel que mejor predice el rendimiento académico en dicha materia curricular. Asimismo, el trabajo pone de manifiesto la utilidad de las medidas de MO en ámbitos educativos.
Sugestões para o alcance das dimensões da sustentabilidade no tratamento dos conhecimentos tradicionais associados à biodiversidade Amazônica
Authors: Matheus Ana Carolina Couto
Published: May 2021

O objeto do trabalho em testilha é estudar as dimensões da sustentabilidade associada aos respectivos problemas e sugerir o alcance da sustentabilidade dos conhecimentos tradicionais associados à biodiversidade amazônica, considerando a imprescindível inter-relação dos conhecimentos tradicionais dos povos da Amazônia com a sustentabilidade. Comporta necessariamente um tratamento transdisciplinar, pois as categorias de construções da realidade são diversas, e, embora diferentes, encontram-se profundamente interligadas ou interdependentes. O método utilizado na fase de investigação e na fase de tratamento dos dados foi o indutivo. Nas diversas fases da pesquisa foram acionadas as técnicas do referente, da categoria, do conceito operacional, da pesquisa bibliográfica e do fichamento. O desenvolvimento do tema pautou-se pela persecução dos objetivos geral e específicos que nortearam a produção. O relatório se encerra com as conclusões e consubstancia o resultado de todos os achados da pesquisa acadêmica, findando por confirmar a hipótese inicialmente concebida, tendo, alfim, alcançado as sugestões para o alcance da sustentabilidade dos conhecimentos tradicionais associados à biodiversidade amazônica.
Controle de convencionalidade da Nova Lei de Migração: Uma observação acerca da questão dos refugiados no Brasil
Authors: Chichera Maria Angélica Chichera Angélica , Glasenapp Ricardo
Published: May 2021

O Direito Internacional estimula o diálogo entre as decisões internas e as diretrizes internacionais, o que impulsiona a atuação conjunta de vários Estados, ocorrendo à internacionalização do direito. No Brasil há tratamento especial para os tratados internacionais de direitos humanos, uma vez que a Emenda Constitucional nº 45 de 8 de dezembro de 2004, lhe conferiu a hierarquia de norma constitucional, passando, deste modo, a integrar o bloco de constitucionalidade. O presente artigo analisará acerca da convencionalidade da Nova Lei de Migração – Lei nº 13.445/2017, especialmente no que diz respeito à questão dos refugiados, com o objetivo de observar a congruência normativa existente diante da hierárquica normativa existente entre a referida lei e os tratados internacionais de Direitos Humanos já ratificados pelo Brasil. Por se tratar de um estudo descritivo e exploratório, será realizado com base na pesquisa bibliográfica e histórica, utilizando-se do método dedutivo.
Proposta de isolamento para aplicação de diamino fluoreto de prata
Authors: Bueno Alice Lage , Diniz Camila Miranda Pimenta Camisassa , Gonçalves Mônica Moura de Faria , Penido Cláudia Valéria de Sousa Resende
Published: May 2021

A utilização de cariostático é uma técnica efetiva para a paralisação da cárie tanto em dentes decíduos quanto em permanentes. Apesar de todas suas qualidades e vantagens, um dos desafios desse produto é seu indesejável efeito antiestético, dependendo da superfície na qual é aplicado. Como um dos componentes deste medicamento é a prata, este provoca manchas de tom acastanhado nos dentes nos quais é aplicado. No caso de contato acidental da substância com pele ou mucosa, o manchamento também pode ocorrer. Estas manchas são reversíveis e desaparecem aproximadamente após uma semana. Para evitar esta intercorrência, neste trabalho será apresentada uma nova proposta de isolamento do campo de trabalho, com objetivo de proteção perioral, para a aplicação de Diamino Fluoreto de Prata (DFP). Será apresentado um caso clínico realizado em uma criança de 9 anos de idade, com cáries interproximais em molares. A técnica deste isolamento será demonstrada detalhadamente, relatando os materiais utilizados e as vantagens perante a técnica convencional de aplicação do material. A técnica proposta é eficaz, de fácil realização, possui baixo custo, boa aceitação pelos pacientes, não é invasiva e diminui as intercorrências.
O papel do enterococcus faecalis no tratamento das infecções endodônticas
Authors: Coelho Fernanda Chaves , Pereira Renato Piai , Silva Rogério Vieira
Published: May 2021

Objetivo: Abordar o papel do enterococcus faecalis no tratamento das infecções endodônticas, por meio de uma revisão de literatura, incluindo os seus principais fatores de virulência e os procedimentos mais eficazes para a sua eliminação. Métodos: Foram catalogadas pesquisas ex vivo, relatos de casos clínicos, revisões sistemáticas com metanálise e revisão de literatura. Foram incluídos artigos publicados nos últimos 12 anos a partir de buscas nas principais bases de dados mundiais, Pubmed, Scielo e Google Schoolar. Conclusão: Foi possível constatar que as principais hipóteses atribuídas ao fracasso endodôntico por enterococcus faecalis são a capacidade de formar biofilme, utilização da bomba de prótons entre outros mecanismos, tornando-os resistentes, tendo como métodos clínicos mais recentes para sua erradicação o uso de soluções com associação da irrigação ultrassônica passiva, medicações intracanais e terapia fotodinâmica.
Editorial
Authors: Verlengia Rozangela
Published: May 2021

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Effect of Instrument-Assisted Soft Tissue Mobilization on Ankle of Range of Motion and Balance in Older Women: A Preliminary Study
Authors: Lee Han Wool , Beak Hyoung Jean , Yoon Eun-Jung , Kim Jooyoung
Published: May 2021

OBJECTIVES This study aims to investigate the effects of instrument-assisted soft tissue mobilization (IASTM) on ankle range of motion (ROM) and balance in older women.METHODS The 20 older women with a history of falls participated in the study, and the study subjects were randomly divided into the IASTM group (n=10) and control group (n=10).RESULTS There were no significant interactions between group and time for ankle ROM and functional reach after 8 weeks of IASTM on older women (P>0.05). Meanwhile, there were significant interactions between group and time for one-leg standing and star excursion balance (P<0.05), and in particular, the IASTM group had greater improvements compared to the control group.CONCLUSION In conclusion, the regular application of IASTM has been shown to improve the balance of older women with a history of falls.
Effectiveness of Kinesio Taping for Dynamic Postural Stability in Adolescent Athletes with Chronic Ankle Instability: A Pilot Study
Authors: Cho Ji-Hoon , Lim Seung-Taek , Ko Jupil
Published: May 2021

OBJECTIVES To determine the effectiveness of K-tape on dynamic postural stability of the injured limb in adolescent athletes with chronic ankle instability (CAI) by measuring reach distance with the modified Star Excursion Balance Test (mSEBT).METHODS Twenty volunteers (20 females [17.78 ± 1.22 yrs], height [163.89 ± 7.69 cm], mass [62.51 ± 9.81 kg]) with CAI. Four strips of K-tape were applied to the injured limb. Participants completed 4 trials of testing (2 with tape, 2 without tape) using the mSEBT as the assessment tool. We applied 4 strips of K-tape to the injured limb and then tested postural stability using the mSEBT to see if there was an increase of reach distance in the mSEBT. Measuring reach distance in Anterior (AN), Posteromedial (PM), Posterolateral (PL) on the injured limb with K-tape and without K-tape condition. We measured the reach distances and then normalized the distance to account for height differences. A repeated measures t-test was used for this study.RESULTS There is no statistically significant different between the condition with K-tape and without K-tape in the reach distances on the mSEBT in adolescent athletes with CAI.CONCLUSIONS Based on the results, there appears to be no improvement of reach distance using the mSEBT in adolescent athletes with CAI. Therefore, clinicians need their thoughtful consideration for applying K-tape to improve dynamic postural stability in adolescent athletes with CAI.
Compound heterozygous Niemann-Pick Type C disease in the neonatal period
Authors: TURAN Özden , ANUK-İNCE Deniz , YİLMAZ Zerrin , ECEVİT Ayşe
Published: May 2021

Yenidoğan döneminde birleşik heterozigot Niemann-Pick Type C hastalığı

Niemann-Pick Tip C hastalığı (NPC), esterifiye olmamış kolesterollerin lizozomlarda depolanması ile karekterize nörodejeneratif bir lizozomal depo hastalığıdır. Otozomal resesif kalıtılan bu hastalıktan NPC1 or NPC2 genleri sorumludur (1). Burada, kardeşi yenidoğan döneminde Niemann-Pick Tip C hastalığı tanısı alan ve NPC1 genetik analizi sonucunda birleşik heterozigot Niemann-Pick Tip C hastalığı saptanan yenidoğan olgusu sunuldu.
Risk factors for venous thromboembolism in patients with spinal cord injury: A single-center Turkish study
Authors: BÖLÜK ŞENLİKCİ Hüma , İKBALİ AFŞAR Sevgi
Published: May 2021

Objective
Spinal cord injury (SCI) occurs due to trauma or non-traumatic conditions may be associated with comorbidities related to cardiovascular system and higher risk for venous thromboembolism (VTE). This study aimed to identify risk factors for VTE in patients with SCI.
Material and Methods
The study included 326 patients diagnosed as SCI that were admitted to the inpatient tertiary research hospital rehabilitation clinic and enrolled in a conventional rehabilitation program. The data were collected retrospectively. Risk factors for developing VTE were identified.
Results
There were no significant differences in age, comorbidities or SCI etiology between the patients with and without VTE. The groups differed significantly in gender, level of injury and duration of SCI. Risk factor for VTE were only level of injury.
Conclusions
The present findings show that paraplegic injury level may be considered risk factor for developing VTE in SCI patients. It should be considered when approaching the possibility of VTE in SCI patients.
Rómer Flóris jegyzeteiből
Authors: Erdélyi Gizella
Published: May 2021

Rómer Flóris jegyzeteiből
Antike und spätantike Textilkunst
Authors: Jacobi Mária
Published: May 2021

Antike und spätantike Textilkunst
Kuzsinszky Bálint - az egyetemi tanár
Authors: Oroszlán Zoltán
Published: May 2021

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Fremde Münzen des 11-13. Jahrhunderts im Karpatenbecken
Authors: Gedai István
Published: May 2021

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Válasz őstörténet könyvem vitáján Gábori Miklós, Kálmán Béle és Harmatta János bírálatára (1966. VI. 30)
Authors: László Gyula
Published: May 2021

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Urgeschichtliche Fundorte der Verwaltungsbezirkes Veszprém
Authors: Torma István
Published: May 2021

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Az avarok és a kereszténység
Authors: László Gyula
Published: May 2021

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Mihalik Sándor: Hann Sebestyén ötvös /1645-1713/ című akadémiai doktori értekezésének bírálata
Authors: László Gyula
Published: May 2021

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A későantik császári paloták alaprajzi tipusának kialakulásához (Data to the Emergence of the Ground Plan Types of Late-Antique Imperial Palaces)
Authors: Tóth Endre
Published: May 2021

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Les monuments byzantines en Hongrie
Authors: László Gyula
Published: May 2021

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Pannonische Stempelziegel III. Limes-Strecke Ad Flexum-Ad Mures
Authors: Lőrincz Barnabás
Published: May 2021

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3D reconstructions using GPR data at the Mont Beuvray
Authors: Timár Lőrinc , Czajlik Zoltán , Puszta Sándor , Holl Balázs
Published: May 2021

This short case study had the aim to show a possible use of 3D visualization of ground penetrating radar (GPR) results. GPR’s main advantage over magnetometry is the presence of data related to the depth of the structures under the soil. This feature could be easily exploited using CAD applications and the results provide a great help for the evaluation of the GPR results.
Gemstone and glass inlaid fine metalwork from the Carpathian Basin: the Hunnic and Early Merovingian Periods
Authors: Horváth Eszter
Published: May 2021

Abstract of PhD thesis submitted in 2013 to the Archaeology Doctoral Programme, Doctoral School of History, Eötvös Loránd University, Budapest under the supervision of Tivadar Vida.
The border- and self-defence of Szeklers from the Medieval Age till the Age of Principality. Castles and other defence objects in the settlement history of Udvarhelyszék
Authors: Sófalvi András
Published: May 2021

Abstract of PhD thesis submitted in 2013 to the Archaeology Doctoral Programme, Doctoral School of History, Eötvös Loránd University, Budapest under the supervision of József Laszlovszky.
The Biesheim cameo – a reinterpretation
Authors: Juhász Lajos
Published: May 2021

In this paper I will analyse in depth the Biesheim cameo to which only minor attention was paid until now. There are still some parts of the interpretation that do not fit well together. This is why I have tried to undertake a thorough iconographic analysis that resolved in a new interpretation. In my opinion, the defeated enemy on the cameo can only be Armenia, instead of a Quadic king. Then again the rider is not likely to be Commodus, as previously thought, but rather Lucius Verus. This theory is also supported by a number of personifications of Armenia that were frequent in this period.
Some notes on the rings with sacred inscriptions from Pannonia
Authors: Szabó András
Published: May 2021

More than a hundred rings bearing inscriptions are known from the territory of Roman Pannonia. Among these close to 30 artefacts can be regarded as rings displaying inscriptions of religious significance. Besides the Silvanus-rings, well-known to the archaeological research, some new groups of rings featuring sacred inscriptions can be distinguished according to the dedications. The aim of this paper is to analyse these objects and their religious backgrounds with the help of some archaeological, epigraphical and literary sources and to point out some of the questionable observations of the earlier research.
The coinage of Flavia Maxima Helena
Authors: Vida István
Published: May 2021

Three late Roman silver coins bearing the name Flavia Maxima Helena became known in the recent years. This study discusses their date and the background of the issue, and also identifies the person, whom the coins were minted to as Helena, wife of Julian II.
The first in situ Old Stone Age assemblage from the Rába Valley, Northwestern Hungary
Authors: Mester Zsolt , Faragó Norbert , Király Attila
Published: May 2021

Due to the construction of the M86 motorway, intensive quarrying activity started at several locations of the Rába Valley in Northwestern Hungary. This undertaking provided the discovery of a new archaeological site near the village of Páli in August 2014. During the rescue excavation, a rich lithic assemblage was unearthed, suggesting a human occupation related to the Epipalaeolithic–Early Mesolithic period. It is the first in situ site preceding the Neolithic in the region.
Preliminary Report on the first season of fieldwork in Berettyóújfalu-Szilhalom
Authors: Neumann Daniel , Siklósi Zsuzsa , Scholz Roman , Szilágyi Márton
Published: May 2021

This study aims to present the first results of fieldwork conducted by the teams of the Römisch-Germanische Kommission (Frankfurt am Main) and the Institute of Archaeological Sciences of Eötvös Loránd University (Budapest) in the scope of a joint project. The investigated tell site, Berettyóújfalu-Szilhalom is well known by prehistoric archaeology due to earlier excavations. The main goals of the project were to gain a better understanding of Late Neolithic tell formation processes, to investigate the relations of a tell and its adjacent horizontal settlement and to get a more detailed picture on the Late Neolithic–Early Copper Age transition. Therefore we re-opened the refilled trench of the excavation carried out in 1976, collected bone, soil and micromorphological samples for further examinations, performed geomagnetic prospections, made drillings and field surveys.
Short report on the excavations in the civil town of Brigetio (Szőny-Vásártér) in 2014
Authors: Bartus Dávid , Borhy László , Számadó Emese
Published: May 2021

Excavations in the 2014 season at the site Brigetio/Szőny-Vásártér were concentrated on unearthing the cellar which had been found in 2012 as well as taking observations in the vicinity of the previously excavatedmetal-workshop nearby. Most important results of the excavations are the complete cleaning and documentation of the cellar with collapsed wooden ceiling, as well as unearthing a large pit in the territory of the metal workshop containing a great amount of metal slags, bronze objects (including the head of a Germanic warrior) and even blue pigment raw material.
Short report on the excavations in 2014 of the Department of Hungarian Medieval and Early Modern Archaeology (Eötvös Loránd University, Budapest). Excavations at Castles Čabraď and Drégely, and at the Pauline Friary at Sáska
Authors: Mordovin Maxim
Published: May 2021

The Department of Hungarian Medieval and Early Modern Archaeology carried out three excavations in 2014, including two castles (Drégely and Čabraď) and a monastic site (Sáska – Bakonyszentjakab). The first two provided mainly early modern material, while the last one existed from the 13th until the mid-16th century.
Late groups of the Alföld Linear Pottery culture in north-eastern Hungary. New results of the research in Borsod-Abaúj-Zemplén County
Authors: Csengeri Piroska
Published: May 2021

Abstract of PhD thesis submitted in 2014 to the Archaeology Doctoral Programme, Doctoral School of History, Eötvös Loránd University, Budapest under the supervision of Pál Raczky.
Animal remains from the mid 12th–13th century (Árpád Period) village of Kána, Hungary
Authors: Daróczi-Szabó Márta
Published: May 2021

Abstract of PhD thesis submitted in 2014 to the Archaeology Doctoral Programme, Doctoral School of History, Eötvös Loránd University, Budapest under the supervision of László Bartosiewicz.
Manorial and urban manufactories in the 17th century in Sárospatak
Authors: Ringer István
Published: May 2021

Abstract of PhD thesis submitted in 2014 to the Archaeology Doctoral Programme, DoctoralSchool of History, Eötvös Loránd University, Budapest under the supervision of István Feld.
Quantitative and GIS-based archaeological analysis of the Late Roman rural settlement of Ács-Kovács-rétek
Authors: Vágvölgyi Bence
Published: May 2021

One of the biggest problems archaeologists face during interpretation is the fragmented and incomplete nature of the datasets often produced by field work. In most cases, the excavation of a whole site is not possible, and even the find material is so fragmented as to make their interpretation quite problematic. Such is the case of Ács-Kovács-rétek, a small Late Roman rural settlement, a part of which was excavated in 2009–2010. These excavations provided a very deep insight into the life of the village, but due to their limited scope, they still left a number of questions unanswered. For a more thorough interpretation of the site, we have to look at the find material and its spatial and chronological context from as many different angles as possible. Such analyses have to rely heavily on very detailed quantitative and GIS-based methods that can not only hold large amounts of very diverse information, but can also recombine this information for statistical and spatial analyses that can deepen our understanding of the site. The aim of this paper is to demonstrate the power of detailed quantitative databases and methods for site interpretation through the study of a Late Roman settlement, Ács-Kovács-rétek. During the course of this research a large number of attributes of the find material and the site itself were recorded in structured databases. Thanks to the rational structuring of this data, it could not only be statistically analyzed, but also compared to other sites as well, helping to solidify the timeframe in which the settlement was inhabited, and also uncovering several interesting patterns about its inhabitants. Furthermore, the combination of this data with spatial information even helped to recognize certain changes and spatial patterns within the settlement itself. By the end of my research, a clear picture emerged of this Late Roman village, showing a Romanized population living here from the end of the 3rd through the 4th century AD that not only had connections regionally, but also fit into a local rural landscape in the hinterlands of the \textit{Ripa Pannonica}.
Barbarico more testudinata. The Roman image of Barbarian houses
Authors: Timár Lőrinc
Published: May 2021

There are only few Antique literary sources on simple buildings and depictions which show huts or Barbarian houses are scarce too. The short study makes an attempt to identify structural details that were shown on Late Roman coins and link them to other surviving images.
Preliminary report on the field surveys and excavations in the vicinity of Berettyóújfalu
Authors: Füzesi András , Bartus Dávid , Fülöp Kristóf , Juhász Lajos , Rupnik László , Siklósi Zsuzsanna , Szabó Gábor V. , Szilágyi Márton , Váczi Gábor
Published: May 2021

The staff of the Institute of Archaeological Sciences at the Eötvös Loránd University carried out rescue excavationsprior to the construction of the M4 motorway in Hajdú-Bihar County in 2015. Within the frames of this project theopportunity was given to unearth approximately 5 hectares of a multi-period site east of the city of Berettyóújfalu.Before this excavation systematic field surveys had been carried out on the same site in a 24 hectares large area inthe frames of an OTKA (Hungarian Scientific Researh Fund) project in 2013. Thus there is a possibility to compare thedata of the fieldwalking with the results of the excavation.
History of the settlement of the Sand Ridges of Kiskunság between the 13th–16th century
Authors: Rosta Szabolcs
Published: May 2021

Abstract of PhD thesis submitted in 2015 to the Archaeology Doctoral Programme, Doctoral School of History, Eötvös Loránd University, Budapest under the supervision of József Laszlovszky.
Detection of Exudates and Microaneurysms in the Retina by Segmentation in Fundus Images
Authors:   , Bernal-Catalán E.
Published: May 2021

This article proposes two methodologies for the detection of lesions in the retina, which may indicate the presence of diabetic retinopathy (DR). Through the use of digital image processing techniques, it is possible to isolate the pixels that correspond to a lesion of RD, to achieve segmenting microaneurysms, the edges of the objects contained in the image are highlighted in order to detect the contours of the objects to select by size those that meet an area of 15 to 25 pixels in the case of 512x512 images and identify the objects as possible microaneurysms, while for the detection of exudates the green channel is selected to contrast the luminous objects in the retinography and from the conversion to gray scale, a histogram is graphed to identify the ideal threshold for the segmentation of the pixels that belong to the exudates at the end of the optical disk previously identified by a specialist. A confusion matrix supervised by an ophthalmologist was created to quantify the results obtained by the two methodologies, obtaining a specificity of 0.94 and a sensitivity of 0.97, values that are outstanding to proceed with the classification stage.
Recordings with multiple Neuropixels probes in head-restrained mice v1
Authors: Chen Susu , Svoboda Karel
Published: May 2021

Step-by-step instructions for electrophysiological recordings using multiple Neuropixels probes in head-fixed mice
Two forms of yawning modulation in three months old infants during the Face to Face Still Face paradigm v1
Authors: Menin Damiano
Published: May 2021

The last decades have seen an increasing interest in the phenomenon of yawning and the dynamics of its modulation, yet no widespread consensus exists on its origins and potential functions. Although most scholars have focused on its potential physiological functions, e.g., related to thermoregulation, arousal modulation or cortisol levels, an emerging line of research has been investigating the social implications of yawning, including its hypothesized relationship with empathy. This protocol is designed in order to test for potential gender differences in yawning and self-touch hand movements occurrences during the Face to Face Still Face (FFSF) procedure. Moreover, through the use of path analysis, the protocol allows to investigate potential dynamics of facilitation, inhibition or covariance, between and within the two behavioral patterns across the three episodes of the paradigm. Analogous protocols can be used to test analogous hypotheses with regard to other behavioral patterns.
OMS Atlas FFPE Spatial Mapping v2
Authors: Johnson Brett , Galipeau Danielle , Camp Todd , Thomas George
Published: May 2021

This protocol describes the procedure by which the OMS Atlas serially sections a FFPE block, prepares the resulting slides, and then distributes the specimens for downstream analysis.
Prevalence of skin disease among adolescent girls and their impact on quality of life
Authors:   Assistant Professor, Department of Pediatrics, Mallareddy Medical College, Suraram, Hyderabad, India, Gurram Dr. Deepika , Kumar Dr. K. Pavan ,   Associate Professor, Department of Pediatrics, MNR Medical College, Sangareddy, Telangana, India, Pavan Dr. Indira ,   Consultant Dermatologist, Omega Clinics, Hyderabad, Telangana, India, Chary Dr. Eshwara ,   Professor and Head, Department of Pediatrics, MNR Medical College, Sangareddy, Telangana, India
Published: May 2021

Introduction: Skin diseases can adversely affect the quality of life of an individual. Adolescence is acritical time in biophysical development and adverse skin conditions during this period can alter thegrowth in self-confidence and self-esteem and social engagement. Purpose: The present study wasdesigned to assess the burden, the pattern of skin diseases and their impact on their quality of life inadolescent students. Materials and Methods: A total of 23 schools having 3581 students between10-16 years of age were visited, out of which 3367 students were covered and screened. Skincharacteristics such as the severity of skin disease were recorded by the attended physician. Adermatology life quality index (DLQI) questionnaire was used to assess the effect of skin diseases ontheir quality of life. Results: Among the total cases 2,783 (82%) had skin diseases, of the651(19%) had two or more 2 skin diseases. Prevalence of infectious skin diseases was more in (10-12) young age groups 78.5% as compared to (13-16) later age groups of 55.2% (p<0.01).Pediculosis (52%) has a high point of prevalence, followed by scabies (25%), Pityriasis alba (6.6%),Seborrheic dermatitis (5%), Pyoderma (3.3%), Acne (2.6%) and Tinea (2%). Pediculosis andscabies together constitute 77% of all skin diseases. Conclusion: Good hygiene practices likeregular bathing, regular head wash, and hand wash should be taught to children. Hence training ofschool teachers and PHC doctors regarding the management of common skin diseases and Healtheducation to parents or guardians of children about Hygienic measures, sexual behaviour and needof seeking medical advice.
A Model of Secure Functioning of Computer Systems
Authors:   HSE University, Moscow, 101000, Russian Federation, Galatenko A. V. , Kuzovikhina V. A. ,   New school, Moscow, 119192, Russian Federation
Published: May 2021

We propose an automata model of computer system security. A system is represented by a finite automaton with states partitioned into two subsets: "secure" and "insecure". System functioning is secure if the number of consecutive insecure states is not greater than some nonnegative integer k. This definition allows one to formally reflect responsiveness to security breaches. The number of all input sequences that preserve security for the given value of k is referred to as a k-secure language. We prove that if a language is k-secure for some natural and automaton V, then it is also k-secure for any 0 < k < k and some automaton V = V (k). Reduction of the value of k is performed at the cost of amplification of the number of states. On the other hand, for any non-negative integer k there exists a k-secure language that is not k"-secure for any natural k" > k. The problem of reconstruction of a k-secure language using a conditional experiment is split into two subcases. If the cardinality of an input alphabet is bound by some constant, then the order of Shannon function of experiment complexity is the same for al k; otherwise there emerges a lower bound of the order nk.
Synthesis of H-Infinity Controllersin a Finite Time Interval
Authors: Panteleev A.V. , Yakovleva A.A.
Published: May 2021

The article considers a problem of stabilization of an aircraft, which can be solved by finding output control. Sufficient conditions for H-inf- output control for linear dynamic systems are obtained. Two approximate methods of closed-loop systems synthesis are proposed. The first one is based on finding a pseudo-inverse matrix of the linear measuring system model. The second one based on synthesizing an asymptotic observer, which allows to formulate an estimate of a state vector, giving a possibility of further use of the obtained estimate in the control law. The paper contains a step-by-step algorithm of finding an H-inf -control of a closed-loop system.
Seismic areas and secular magnetic variations*
Authors: Omer Guy C.
Published: May 2021

A good geographical coincidence is observed to exist between areas of anomalous change in the earth's secular magnetic field and the western Indian Ocean, the Mid-Atlantic Ridge, and the Easter Island Ridge seismic zones. Suggestive relationships are noted between changes in the earth's secular magnetic field and other areas of shallow seismicity.
Central California earthquakes of the 1830's
Authors: Louderback George D.
Published: May 2021

The information and inferences therefrom concerning central California earthquakes reported as occurring in the 1830's, according to the conclusions reached in the foregoing discussion, may be summarized as follows.

1836—April 25, 5 a.m. A “strong” shock. Monterey. This may possibly be a foreshock of the June 10 earthquake. If so, it must have been felt at points around the Bay of San Francisco, but no reports are available.

1836—June 9, about 4 p.m. Monterey. Described as strong and short by Gomez; strong, and of about a half minute's duration, by Vallejo. It is probably a foreshock of the earthquake of the next morning, but no reports are available from other localities.

1836—June 10, 7:30 a.m. X. East of San Francisco Bay. An earthquake of great intensity comparable with and possibly stronger than that of October 21, 1868. Large fissures were formed and “innumerable” aftershocks occurred, decreasing in violence, but “continuous” for a month. The account stresses the effects along the foothill belt from San Pablo to Mission San Jose, which indicates an origin in the Haywards fault. The fissures were probably, at least in part, fault-trace phenomena. Reported by Gomez in Monterey as of more violence and duration than the shock of June 9. Described by Vallejo as strong, lasting close to a minute in Monterey, causing havoc in Monterey and Santa Clara, and arousing great fear among the people. Intensity apparently at least VII at Monterey and Mission Carmel.

1838—Late in June, just after noon. X. Comparable with the earthquake of April 18, 1906. Originated in the San Andreas fault, and violent fault-trace phenomena described by Charles Brown as observed in the hills behind Palo Alto near the present Searsville Lake: a great fissure which he describes as ten to twelve feet wide and running from near San Francisco to the latitude of of Santa Clara; the ground cracked in all directions; thousands of trees broken off; water thrown from creek bed; adobe walls cracked. Violent at Yerba Buena (San Francisco), walls cracked at Presidio, a sand hill bodily shifted (according to Spear); house shaken down at San Jose (town), and walls badly injured at the San Francisco, Santa Clara, and San Jose missions (Captain Paty); crockery and glassware broken, walls of adobe buildings cracked, inhabitants “frightened out of their wits” in Monterey (Major Warren). Captain Paty reported aftershocks as “frequent since” (his ship left the coast September 19, 1838). The fault rupture may have occurred throughout all or most of the line active in 1906, but north and south beyond the limits indicated by Brown it lay under water or in wild country uninhabited by whites (except at Fort Ross, from which we have no report). The evidence of greater intensity at Monterey than in 1906 may mean that the fault rupture extended farther south in 1838 than in 1906.
On seismic rays and waves*
Authors: Fu C. Y.
Published: May 2021

The equations of motion of an elastico-viscous medium in which the material constants vary with position are deduced. These can be put into the form of a wave equation only when the gradients of the constants are small. By the method of Sommerfeld and Runge these equations are compared with the equation of the characteristic function, whence the condition for the validity of the ray method is obtained. It is similar to De Broglie's criterion in wave mechanics. Expressed in terms of measurable quantities in seismology, the condition is applied to the data recently obtained by Gutenberg for the upper layers of the earth's crust. The equation of the characteristic function is used in deriving the forms of the ray paths for several particular velocity functions, following a method previously used by Epstein.