bluuebunny/crossref_metadata_2025 huggingface dataset:
Co-design of a Smartphone App for People Living With Dementia by Applying Agile, Iterative Co-design Principles: Development and Usability Study
Authors: Fox Sarah , Brown Laura J E , Antrobus Steven , Brough David , Drake Richard J , Jury Francine , Leroi Iracema , Parry-Jones Adrian R , Machin Matthew
Published: October 2021

Background

The benefits of involving those with lived experience in the design and development of health technology are well recognized, and the reporting of co-design best practices has increased over the past decade. However, it is important to recognize that the methods and protocols behind patient and public involvement and co-design vary depending on the patient population accessed. This is especially important when considering individuals living with cognitive impairments, such as dementia, who are likely to have needs and experiences unique to their cognitive capabilities. We worked alongside individuals living with dementia and their care partners to co-design a mobile health app. This app aimed to address a gap in our knowledge of how cognition fluctuates over short, microlongitudinal timescales. The app requires users to interact with built-in memory tests multiple times per day, meaning that co-designing a platform that is easy to use, accessible, and appealing is particularly important. Here, we discuss our use of Agile methodology to enable those living with dementia and their care partners to be actively involved in the co-design of a mobile health app.

Objective

The aim of this study is to explore the benefits of co-design in the development of smartphone apps. Here, we share our co-design methodology and reflections on how this benefited the completed product.

Methods

Our app was developed using Agile methodology, which allowed for patient and care partner input to be incorporated iteratively throughout the design and development process. Our co-design approach comprised 3 core elements, aligned with the values of patient co-design and adapted to meaningfully involve those living with cognitive impairments: end-user representation at research and software development meetings via a patient proxy; equal decision-making power for all stakeholders based on their expertise; and continuous user consultation, user-testing, and feedback.

Results

This co-design approach resulted in multiple patient and care partner–led software alterations, which, without consultation, would not have been anticipated by the research team. This included 13 software design alterations, renaming of the product, and removal of a cognitive test deemed to be too challenging for the target demographic.

Conclusions

We found patient and care partner input to be critical throughout the development process for early identification of design and usability issues and for identifying solutions not previously considered by our research team. As issues addressed in early co-design workshops did not reoccur subsequently, we believe this process made our product more user-friendly and acceptable, and we will formally test this assumption through future pilot-testing.
Clinical Impact of an Analytic Tool for Predicting the Fall Risk in Inpatients: Controlled Interrupted Time Series
Authors: Cho Insook , Jin In sun , Park Hyunchul , Dykes Patricia C
Published: October 2021

Background

Patient falls are a common cause of harm in acute-care hospitals worldwide. They are a difficult, complex, and common problem requiring a great deal of nurses’ time, attention, and effort in practice. The recent rapid expansion of health care predictive analytic applications and the growing availability of electronic health record (EHR) data have resulted in the development of machine learning models that predict adverse events. However, the clinical impact of these models in terms of patient outcomes and clinicians’ responses is undetermined.

Objective

The purpose of this study was to determine the impact of an electronic analytic tool for predicting fall risk on patient outcomes and nurses’ responses.

Methods

A controlled interrupted time series (ITS) experiment was conducted in 12 medical-surgical nursing units at a public hospital between May 2017 and April 2019. In six of the units, the patients’ fall risk was assessed using the St. Thomas’ Risk Assessment Tool in Falling Elderly Inpatients (STRATIFY) system (control units), while in the other six, a predictive model for inpatient fall risks was implemented using routinely obtained data from the hospital’s EHR system (intervention units). The primary outcome was the rate of patient falls; secondary outcomes included the rate of falls with injury and analysis of process metrics (nursing interventions that are designed to mitigate the risk of fall).

Results

During the study period, there were 42,476 admissions, of which 707 were for falls and 134 for fall injuries. Allowing for differences in the patients’ characteristics and baseline process metrics, the number of patients with falls differed between the control (n=382) and intervention (n=325) units. The mean fall rate increased from 1.95 to 2.11 in control units and decreased from 1.92 to 1.79 in intervention units. A separate ITS analysis revealed that the immediate reduction was 29.73% in the intervention group (z=–2.06, P=.039) and 16.58% in the control group (z=–1.28, P=.20), but there was no ongoing effect. The injury rate did not differ significantly between the two groups (0.42 vs 0.31, z=1.50, P=.134). Among the process metrics, the risk-targeted interventions increased significantly over time in the intervention group.

Conclusions

This early-stage clinical evaluation revealed that implementation of an analytic tool for predicting fall risk may to contribute to an awareness of fall risk, leading to positive changes in nurses’ interventions over time.

Trial Registration

Clinical Research Information Service (CRIS), Republic of Korea KCT0005286; https://cris.nih.go.kr/cris/search/detailSearch.do/16984
Conducting Digital Health Care Research: Document Analysis of Challenges Experienced During Intervention Development and Feasibility Study Setup of an Internet-Administered Intervention for Parents of Children Treated for Cancer (Preprint)
Authors: Woodford Joanne , Karlsson Mathilda , Hagström Josefin , Hägg Sylvén Ylva , Norbäck Kajsa , Grönqvist Helena , von Essen Louise
Published: October 2021

BACKGROUND

The design and conduct of research to develop, test, and evaluate complex health care interventions is challenging. Although the existing literature describes key challenges associated with the design and conduct of definitive (evaluation) trials, there is a lack of information concerning specific challenges associated with the intervention development phase and setup of feasibility studies. In particular, the literature is scarce concerning the challenges associated with conducting digital health care research, such as research on internet-administered interventions and research using digital features to support the execution of study procedures (eg, recruitment, consent, retention, and data collection and management). This study is conducted in the context of the intervention development and feasibility study setup phases of an internet-administered, guided, low-intensity cognitive behavioral therapy–based intervention for parents of children previously treated for cancer.

OBJECTIVE

The aim of this study is to explore the challenges experienced during the development phase of the internet-administered intervention and digital features to support the execution of the study procedures and a feasibility study setup.

METHODS

To explore the key challenges experienced, we conducted a document analysis of written records from all study meetings held by the research team (meeting minutes) between June 7, 2018, and January 10, 2020, guided by a thematic analysis approach. Furthermore, discussion groups with members of the research team were held to develop a more detailed understanding of the key challenges experienced. Methods and results are reported in accordance with the relevant items from the Standards for Reporting Qualitative Research checklist.

RESULTS

Six main themes were identified: decision-making and communication, expertise, external constraints, flexibility, planning and scheduling, and technical constraints.

CONCLUSIONS

Significant challenges were experienced during the intervention development and setup phases of the feasibility study. Implications are discussed to inform future design, conduct, and planning of internet-administered intervention development and feasibility studies, especially within the context of digital health care research.
A Bakhtinian Approach to the Study of Eighteenth-Century English Gothic Novels
Authors: Chen Shuping
Published: October 2021

M. M. Bakhtin in the third essay of The Dialogic Imagination coined the term “chronotope” to denote the interaction and integration of time and space in novelistic narratives. Bakhtin’s concept of chronotope emphasizes that time and space coordinate with each other rather than insist on their individualities in narratives. The major chronotope of the novel usually determines its generic characteristics. The current study attempts to utilize Bakhtin’s notion of chronotope to anatomize the time-space structure of major Gothic novels in the eighteenth century, namely, Horace Walpole’s The Castle of Otranto (1764), Ann Radcliffe’s Athlin and Dunbayne (1789), A Sicilian Romance (1790), The Romance of the Forest (1791), and The Mysteries of Udolpho (1794), for the purpose of detecting and summarizing the common features of the Gothic genre. Manifold approaches and theories had been applied in this area, but it is the first time that Bakhtin’s chronotope was employed in the stylistic study of eighteenth-century Gothic novels written by Walpole and Radcliffe.
Women and Weasels: a Medico-religious Approach to Maternity in a Republican City of Lazio
Authors: Thibaut Émilie
Published: October 2021

Medicine and magico-religious practices went hand in hand in Greco-Roman societies, because they attached enormous importance to divine manifestations. Insofar as the gods were present everywhere and in all circumstances, it was necessary to scrupulously respect the rituals which were practised in their honour. Without these rituals, peace with the gods could be disrupted. In the town of Palestrina (Lazio), a votive deposit was unearthed near the foundations of a sanctuary. It contained several effigies of Juno as well as eight very original little statuettes with the breasts of a woman but the body of a weasel. In addition, there were also weasel’s bones and metal keys. Even though it seems logical to think that the religious complex and these offerings were evoted to the goddess, it is more difficult, however, to understand the link between Juno and the different offerings. Why were they placed there and by whom?
Non est mea pigra senectus: Old Women and Folk Medicine in Greco-roman Literature
Authors: Meseguer González Diego
Published: October 2021

This paper will examine the old-woman healer figure through Greco-Roman literary sources. First, I will discuss briefly the social reputation of old women in comparison with senex and the creation of a negative stereotype around them. After that, I will focus on the triple relation between woman, old age, and medicine in order to show the reputation of old women as skilled healers. Finally, I will analyse the use of different treatments close to magic, like enchantments and purifications, and the healings of some specific illnesses, such as love, to conclude with a brief overview of the political and social attitude towards them.
Carmen de viribus herbarum (GDRK 64): Between Magical Pharmacology and Homeric Didactic
Authors: Overduin Floris
Published: October 2021

This paper aims to assess the nature of magic and medicine in the extant fragment of the little-known Carmen de viribus herbarum (fr. 64 Heitsch), an anonymous didactic poem of considerable length (216 hexameters have been transmitted) from the third century CE. The Carmen, a poem concerned with the curative powers of some fifteen different plants, is an evident descendant of the didactic pharmacological verse tradition of Nicander of Colophon and the like, yet its method of composition, reusing large chunks of Homeric lines, is remarkable. What sets the Carmen apart from the tradition of didactic pharmacology, moreover, is its fascination with magic, a factor virtually absent from the Nicandrean legacy. Next to pharmacological knowledge it repeatedly discusses effective plants against ghosts, apparitions, and witches.
Prospects of seabuckthorn breeding activity at Lisavenko Research Institute of Horticulture for Siberia
Authors: Zubarev Yuri A. , Gunin Aleksey V. , Panteleeva Elizaveta I. , Vorobjeva Anastasia V.
Published: October 2021

Seabuckthorn gene pool in collections of Lisavenko Research Institute of Horticulture for Siberia which is a division of the Federal Altai Scientific Center of Agro-BioTechnologies is represented by more than 14 thousand hybrid seedlings and over 450 varieties under selection. It allows to provide comprehensive selection on different agronomic traits and to achieve permanent assortment improvement. The main aim of the research was to select seabuckthorn varieties distinguished by characteristics that meet the requests of industrial sector with focus on various technological approaches. Seabuckthorn varieties of hybrid origin from crossbreeding of 1993-2005 were studied. The experiments were carried out in forest-steppe zone of Altai Krai in 2016-2020. According to the results of comprehensive evaluation, groups of the most promising varieties were proposed as a source of various agronomic traits. The potential of breeding activity was shown as well as possibility of seabuckthorn assortment improving was proved. In particular, within sweet-fruited varieties such samples as 57-01-1, 146-02-1 and 226-00-1 with sugar-acid index of 6.4, 5.4 and 5.3, respectively, have been selected as well as fruit of 198-99-3a and 62-01-2 varieties weighed about 1.0 g, that is almost 0.3 g higher compared to Chuiskaya variety (control) and Altaiskaya (the sweetest one). Two varieties - 149-00-3 and 664-00-2 - were included to the group with very low tear-off force of fruits - 95 and 110 g, respectively, which was significantly lower compared to the control (Chuiskaya) and the standard variety (Anastasia). That means high suitability of these varieties for harvesting by hand picking. The hybrid 185-99-5 had an average fruit weight of 1.67 g which was two times higher than fruit weight of the control variety. Highly promising red colored variety (258-03-1) had high oil content in fruits. That positions it as an extremely promising variety for seabuckthorn oil concentrate processing. Most of estimated varieties were included in various reference groups demonstrating by that the combination of agronomic traits.
Creating Healing and Therapeutic Landscapes: Design Experience
Authors: Krasilnikova Elina E. , Zhuravleva Inna V. , Zaika Inna A.
Published: October 2021

Healthy longevity is becoming the main element in assessing the quality of the formed urban environment. The relevance of creating a comfortable urban environment is of great importance for leveling the negative processes of urbanization, burdened by globalization and COVID-19. The article presents the results of designing health-improving landscapes with their integration into the urban-ecological framework of the urban greening system of Sevastopol. The study of the design area was carried out using generally accepted methods of field research.
Effect of fiber and energy in diet on productivity and formation of microbiocenosis in piglets
Authors: Vorobyova Nelly V. , Popov Viktor S.
Published: October 2021

Today, an important role in the development of pig breeding is given to feeding animals, especially piglets during the transition from milk to vegetable feeding. This crucial period is associated with physiological characteristics of piglet growth and development. Therefore, the problem of developing mixed fodder that gives rise to high weight gain in piglets is relevant for pig farming. The experiments were conducted on piglets aged 15-42 days in Nadezhda farm, Kursk region. The purpose of the research was to increase productivity and form the microbiocenosis in the intestines of piglets. During the study period, barley-wheat mixed fodder was used with additional ingredients: feed fat, alfalfa grass flour and probiotic. Feed fats provide an optimal level of energy for piglets growth. The active substances of alfalfa flour are involved in all metabolic processes in the body, making it effective. Probiotic increases availability and digestibility of feed nutrients. The studies proved that the new composition of SK-3 increased the average daily weight gain by 20.5 %, the gross formation per piglet increased to 21 %. At the same time, survival of animals in the period 15-42 days increased to 100 %. The greatest growth of beneficial intestinal microflora from 107 to 109 CFU/g of feces was observed after feeding experimental piglets with mixed fodder containing grass flour, feed fats and probiotic by day 42. In comparison with the control animals, experimental animals showed a decrease in E. coli - from 107 to 104. The importance of using such ingredients as alfalfa grass flour, feed fats and probiotic in mixed fodder for piglets of 15-42 days of age was revealed. The relevance of the development of new mixed fodder was justified.
FUNDAMENTAL PRINCIPLES OF THE LEGISLATION PROCESS
Authors: Aulia Yassar , Abdurahman Ali , Susanto Mei
Published: October 2021

The Indonesian legislative process in recent years has been facing various serious procedural flaws. Most notably illustrated by at least three contemporary cases, namely regarding the process of the second amendment to Law No. 30 of 2002 concerning the Corruption Eradication Commission (hereinafter referred to as the KPK Law); the third amendment to Law No. 24 of 2003 concerning the Constitutional Court (MK Law); and the formation of Law No. 11 of 2020 concerning Job Creation (Job Creation Law). The purpose of this paper is to see whether in practice, the legislative process in Indonesia has aligned itself with the fundamental principles of the legislative process and to see whether the legal framework regarding procedures during the law-making process are adequate. Through descriptive analytical research and comparative approach with the United Kingdom, this paper found that the Indonesian law-making process in practice is not in line with the fundamental principles of the legislative process. We also found that the legal framework regarding the procedure for making laws in Indonesia to be inadequate and therefore we suggest that it can draw some lessons from the practices of the British Parliament.

Abstrak: Pembentukan undang-undang (UU) di Indonesia dalam beberapa tahun terakhir memiliki berbagai kecacatan prosedural yang serius.  Kekacauan proses legislasi di Indonesia paling terang terilustrasikan jika melihat setidaknya tiga kasus kontemporer, yakni mengenai proses pembentukan UU No. 19 Tahun 2019 tentang Perubahan Kedua atas UU No. 30 Tahun 2002 tentang Komisi Pemberantasan Tindak Pidana Korupsi (selanjutnya disebut UU KPK), UU No. 7 Tahun 2020 tentang Perubahan Ketiga atas UU No. 24 Tahun 2003 tentang Mahkamah Konstitusi (UU MK), dan UU No. 11 Tahun 2020 tentang Cipta Kerja (UU Cipta Kerja). Tujuan dari tulisan ini adalah untuk melihat apakah dalam praktik, proses pembentukan UU di Indonesia telah menyelaraskan diri dengan prinsip-prinsip fundamental proses pembentukan undang-undang dan melihat apakah pranata hukum prosedural yang berlaku telah memadai. Melalui spesifikasi penelitian deskriptif analitis dan pendekatan perbandingan hukum dengan Britania Raya, hasil penelitian menunjukkan bahwa praktik pembentukan undang-undang di Indonesia belum selaras dengan prinsip-prinsip fundamental proses pembentukan undang-undang. Pranata hukum mengenai prosedur pembentukan UU yang ada di Indonesia juga kami temukan belum memadai dan oleh karenanya dapat mengambil beberapa pelajaran dari praktik Parlemen Britania Raya.

Kata Kunci: Fast-Track Legislation, Omnibus Law, Pembentukan Undang-Undang, Perbandingan Hukum, Prinsip Prosedural
NAVIGATING THE WATERS: INTERNATIONAL LAW, ENVIRONMENT AND HUMAN RIGHTS
Authors: O. Oyewole Oriola
Published: October 2021

Over the years, the relationship between the environment and human rights has received global attention. The connection between the individuals, environment and international law is indispensable. However, domestic environmental activities and globalisation set domino effects on climate change where the actions within one jurisdiction affect the environment of neighbouring states. Sovereignty, state obligations and human rights are instruments that can regulate the protection of the environment. Set against this background, this paper will assess the contribution of international law to the protection of the environment, particularly the extent of enforceability of general state obligations through the 'no harm rule.' Arguably, transboundary harm is inevitable in most environmental activities. Therefore, the engaging state is obligated to take measures known as due diligence to regulate the transfer of transboundary harm. The threshold for these environmental activities is significant transboundary harm. In addition, it is observed that there is a limit to which state can be held accountable for violations of human rights where corporate actors, through their business activities, have contravened human rights. Hence, through case analysis, this paper examines the extent of corporate legal accountability for environmental degradation.

Abstrak: Selama bertahun-tahun, hubungan antara lingkungan dan hak asasi manusia telah mendapat perhatian global. Hubungan antara individu, lingkungan dan hukum internasional sangat diperlukan. Namun, kegiatan lingkungan domestik dan globalisasi memberikan efek domino pada perubahan iklim di mana tindakan dalam satu yurisdiksi mempengaruhi lingkungan negara tetangga. Kedaulatan, kewajiban negara, dan hak asasi manusia merupakan instrumen yang dapat mengatur perlindungan lingkungan hidup. Dengan latar belakang ini, artikel ini akan menilai kontribusi hukum internasional terhadap perlindungan lingkungan, khususnya sejauh mana keberlakuan kewajiban negara secara umum melalui 'aturan yang tidak merugikan', karena kerusakan lintas batas tidak dapat dihindari di sebagian besar kegiatan lingkungan. Oleh karena itu, negara yang terlibat wajib mengambil langkah-langkah yang dikenal sebagai uji tuntas untuk mengatur pengalihan bahaya lintas batas. Ambang batas untuk kegiatan lingkungan ini adalah bahaya lintas batas yang sangat penting. Selain itu, terlihat adanya batasan dimana negara dapat dimintai pertanggungjawaban atas pelanggaran hak asasi manusia yang dilakukan korporasi, melalui kegiatan usahanya, yang telah melanggar hak asasi manusia. Oleh karena itu, melalui analisis kasus, artikel ini mengkaji sejauh mana akuntabilitas hukum korporasi atas kerusakan lingkungan.

Kata Kunci: Kedaulatan, Uji Tuntas, Lingkungan, Hak Asasi Manusia, Tanggung Jawab Negara, Hukum Internasional
D. Averkiev’s “A Brief Sketch of the Life and Writings of F.M. Dostoevsky” in the Context of Introductions to the Writer’s Collected Works
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Andrushchenko Elena A.
Published: October 2021

The paper establishes the position of D. Averkiev’s foreword among other introductions written for the collected works of F. Dostoevsky over twenty-five years, asserting that it meets the criteria of the biographical essay genre.
V.Ya. Bryusov as a Scholar of Dostoyevsky: an Unfulfilled Intention
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Drovaleva Nataliya A.
Published: October 2021

V.Ya. Bryusov, unlike other eminent literators of the late 19th — early 20th centuries (D.S. Merezhkovsky, A. Bely, etc.), never wrote a separate publication on Dostoyevsky, however it is known that he was preparing a book on an entire corpus of the writer’s literary works. This article presents a plan of his monographic research along with the introductory notes that outline the scope and the general idea of Bryusov’s intention. Dostoyevsky’s novels become an experimental field for setting the goals of scholarly criticism and preparing a classification of his characters based on the notable «ideas» of the writer’s work and the achievements of psychopathography of the time. As the foundation for his classification Bryusov uses masculine and feminine types which, in turn, are grouped into subtypes (Bryusov provides examples from Dostoyevsky’s novels and stories for each type). This analysis of the writer’s texts was supposed to result in a scholarly work founded on a scientific basis, but in the end Bryusov did not fulfill his intentions. It is traditionally thought that the typology of Dostoyevsky’s characters was created in the 1920s, however Bryusov’s diligent work sheds some light on the existence of earlier attempts at creating it.
Discussion about F.M. Dostoevsky’s Novel “Demons” in Russian Criticism of 1918–1935
Authors:   State Social and Humanitarian University, Batalova Tamara P. , Fedianova Galina V. ,   State Social and Humanitarian University
Published: October 2021

The authors of the proposed article aimed to consider the discussion of Dostoevsky’s novel “Demons”, which unfolded in the 1920s — 1930s, in two aspects: from the point of view of its significance for the development of literary studies, and on the other hand, to determine its influence on the new Soviet ideology that was developing at that time. To clarify the first side of the General problem, we studied the works of leading literary critics of that time-V.V. Vinogradov, A.S. Dolinin, L.P. Grossman, V.L. Komarovich, B.M. Engelhardt, V.F. Pereverzev, P.N. Medvedev, and others. The influence of Dostoevsky’s novel “Demons” on the ideology of that time is evidenced by the works of N.A. Berdyaev, Yu.I. Aichenwald, S.S. Borschevsky, the materials of the journal “Vestnik Literatura”, the discussion about Dostoevsky, which gradually manifested itself at the First all-Union Congress of Soviet writers, resulting in the prohibition of a separate publication of the novel “Demons”. The research has shown that works about Dostoevsky of the 1920s — 1930s and, above all, about the novel “Demons”, such as the discussion of the first published Chapter “at Tikhon’s”, are of great importance in the development of dostoevistics. On the other hand, the discussion of the novel “Demons”, especially in the 1930s, became a discussion with a new ideology that contradicts the objective discussion of Dostoevsky’s work. Overcoming this situation has only been possible since the late 1980s.
F.M. Dostoevsky on Vsechelovecheskoe and Vsechelovek: Origin and Reception
Authors:   Institute of Philosophy of the Russian Academy of Sciences, Vorozhikhina Ksenia V.
Published: October 2021

The article is devoted to the origins and reception of the concepts of the vsechelovecheskoe and vsechlovek in the work of the late F. Dostoevsky. N. Danilevsky’s book “Russia and Europe” attracted attention of the writer, because it contained ideas in tune with his own thoughts about the special role of Russia, destinated to unite the Slavs. However, the program of Dostoevsky was significantly different from the conception of Danilevsky: the scientist radically separated religion and politics, while for Dostoevsky religion was called to sanctify politics and point out the ideal of the development of the Russian state, history and humanity; Danilevsky considered the struggle of Russia and Europe inevitable, and the writer believed in the possibility of building of new relations with the Western Europe countries on the Christian fraternal principles. Moreover, Dostoevsky accepted the distinction between universal and vsechelovecheskoe, introduced by the author of “Russia and Europe”. The ideas of vsechelovecheskoe evolved not without the influence of the young philosopher V.S. Solovyov. The historiosophical views of Dostoevsky, concedered by his contemporaries to be overly naive and devoid of robust realism, were adopted by Silver Age thinkers and Eurasians. Using the category of vsechelovecheskoe V.F. Ern and V.I. Ivanov comprehended contemporary historical events, revolutions and wars. The Eurasians, who at first came closer to Danilevsky’s concept with its isolated cultural-historical types, subsequently came to a religious understanding of history in the spirit of A.S. Khomyakov, V.S. Soloviev, F.M. Dostoevsky and others.
“The Stress of Life” in the Work of Dostoevsky and Andreyev in the Light of the Neurophysiological Investigation
Authors:   University of Granada, Moreno Rodríguez Rosa María , Arsentieva Natalia N. ,   University of Granada
Published: October 2021

This article addresses the relationships between Russian literature and the development of psychiatry at the end of the 19th century and the beginning of the 20th century. The research is based on the study of the medical contents drawn from the work of Dostoevsky and Andreyev, which deals with the neurophysiological presuppositions of behavioral psychology, theory inaugurated by Pavlov and Bekhterev, and adaptive responses to stress proposed by Hans Selye. We consider both activities, literature and science, as discourse and praxis of theory, either factually, from the development of drugs or instruments that act on brain functioning, or didactically, through the development of roles and dramatic instruments. Moreover, our research also focuses on the psychological expression in the face of misfortune and the sterility of psychic effort, within the two classical dimensions of anthropology and psychology: the correlation between emotions and reason, and the activation of somatic functions. In their work, both authors coincide in showing a psychopathological and somatic correlate either as insanity, paralysis or death. Finally, we analyzed whether the relationship with science is of dependency or whether it constitutes a core part of a cultural continuum.
Tragedy as a Novel and Philosophy: Architectonics of the Tragic at Dostoevsky
Authors:   Donetsk National University, Kravchenko Oksana A.
Published: October 2021

The article is devoted to the study of the tragic value spectrum of F. Dostoevsky’s works. In the analysis of the critical works of V. Ivanov and L. Shestov identify the constants of the tragic architectonics proposed by these researchers. The conclusion is made about the semantic multidirectionality of the tragic assessments in the reading of F. Dostoevsky. In Ivanov’s interpretation, the hero perceives the lost harmony of spiritual unity as a value and seeks to restore it. In Shestov’s philosophy, the pathos of tragedy consists in the voluntary heroic rejection of harmonious ideals by the individual. In both cases, the tragic, as an architectonic value, acquires specific semantic overtones of 20th century art.
Alexander Zakrzhevky as an Interpreter of Worldview Reflections of the “Dostoevsky Renaissance” Era
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Kozmenko Mikhail V.
Published: October 2021

The article discusses the features of the literary position of A.K. Zakrzhevsky, the author of the trilogy of “psychological parallels”, which connects the name of Dostoevsky with the works and images of a wide range of philosophers and writers of the “silver age”. Despite the deep subjectivism of the critic’s judgments, certain features of the trilogy are in tune with the most important trends in the intellectual and literary-artistic “reformatting” of Dostoevsky’s ideas about the world, which took place at the turn of the 19th and the begging of 20th centuries.
EFETIVIDADE DA POLÍTICA MACROPRUDENCIAL: UM EXERCÍCIO COM BASE NO BUFFER CONTRACÍCLICO
Authors: Brandi Vinicius Ratton , De Andrade Joaquim Pinto
Published: October 2021

Um dos elementos desestabilizadores da crise financeira internacional de2008 foi a amplificação de choques financeiros. A tendência natural dos agentes secomportarem de forma procíclica foi reforçada por meio de outros canais. Dessa forma,as medidas macroprudenciais ganharam maior destaque na busca pela estabilidadefinanceira. Este trabalho traz contribuições que buscam esclarecer os efeitos de determinados instrumentos de regulação macroprudencial sobre variáveis macroeconômicas e financeiras, com base em um modelo que introduz fricções na oferta de créditoem um arcabouço DSGE novo-keynesiano, estimado para a economia brasileira. Osresultados sugerem uma maior adequação do instrumento de política macroprudencial contracíclico no caso de choques que se originam no próprio sistema financeiroe choques de política monetária. No caso dos choques de oferta e de demanda, autilização do instrumento prudencial revela, na maioria das vezes, papel conflitanteaos objetivos da autoridade monetária e resultado não conclusivo a respeito dos benefícios sobre a estabilidade financeira. Na comparação entre os diferentes conceitos deciclo econômico, observa-se que uma maior cooperação da autoridade prudencial emrelação aos objetivos da política monetária é proporcionada quando se utiliza a relaçãoentre crédito e produto como referência para o acompanhamento do ciclo econômico.
EXPANSÃO DA REDE DE TELÉGRAFOS EM SANTA CATARINA: SISTEMA REGIONAL DE ECONOMIA E ADENSAMENTO DO ESTADO NO TERRITÓRIO CATARINENSE
Authors: Goularti Filho Alcides
Published: October 2021

O objetivo deste artigo é descrever a expansão da rede de telégrafos em Santa Catarina entre 1866 e 1930 focalizando a análise na formação do sistema regionalde economia e no adensamento do Estado no território. Parte-se do pressuposto deque transportes e comunicações são unidades constitutivas do território e estão ligadasdiretamente às ações do Estado por meio de múltiplas estratégias e interesses. Alémdas considerações finais, o texto está dividido em quatro tópicos. O primeiro discute arelação entre território e comunicações destacando aspectos teóricos e metodológicosque norteiam o artigo. O segundo tópico aborda a formação do sistema regional deeconomia a as comunicações. No tópico seguinte, temos uma trajetória dos telégrafosno mundo e no Brasil e dados abrangentes da Repartição Geral dos Telégrafos. Porfim, o último tema discutido é a trajetória da expansão da rede de telégrafos em SantaCatarina como um dos elementos determinantes na ocupação, definição e construçãodo território. Esse tópico está subdividido em três períodos: 1866 a 1900 (instalação einício da interiorização); 1900 a 1918 (expansão e integração da rede); e 1918 a 1930(formação do sistema e novos serviços de comunicações). As considerações finais versam sobre o futuro da telegrafia pós-1930 diante dos avanços tecnológicos da área dascomunicações.
ESTIMAÇÃO DO COMÉRCIO INTERNACIONAL BRASILEIRO EM CLUSTERS
Authors: Cateia Júlio Vicente , Oliveira Édivo De Almeira , Barbosa William
Published: October 2021

O objetivo deste estudo é investigar empiricamente o comércio internacionaldo Brasil com seus parceiros comerciais estimado por meio dos estimadores de máximaverossimilhança (MV), Poisson pseudo-maximum likelihood (PPML) e o sistema GMMem um modelo de comércio com bens contínuos. Analisa-se o desempenho das exportações brasileiras para os quatro clusters intercontinentais: o comércio Brasil-Mercosul,Brasil-Brics, Brasil-Zona do Euro e Brasil-Estados Unidos. Os estimadores MV e PPMLreportam estimativas significativas e consistentes com a literatura gravitacional de queas rendas e populações dos países elevam o comércio, enquanto o custo de transportemais alto tende a inibir os fluxos comerciais. A volatilidade cambial não se mostra umimpeditivo ao comércio, ao menos no modelo estático. A fronteira não tem um importante papel na determinação do padrão do comércio entre o Brasil e seus parceirosregionais, sugerindo que os clusters intercontinentais podem ser fundamentais para osfluxos de exportações brasileiras, fato confirmado pelos resultados reportados pelo estimador do sistema GMM.
Tur´an type inequalities for the supertrigonometric functions
Authors: Geng Lu-Lu , Yang Xiao-Jun , Liu Jian-Gen
Published: October 2021

This paper is devoted to the study of Tur\’{an} type
inequalities for some well-known special functions such as supersine and
supercosine which are derived by using a new form of the
Cauchy-Bunyakovsky-Schwarz inequality.
Alpha-L-iduronidase deficiency: A novel mutation resulting in severe early presentation of Mucopolyscaridosis type I and litature review of molecular basis
Authors: alzaabi nuha , sirajum muneera , Al-Wawi Mohd Zaki , Alsuwaiji Mohammed
Published: October 2021

The IDUA gene (MIM 252800) provides instructions for producing
alpha-L-iduronidase, which is essential for the breakdown of
glycosaminoglycans (GAGs). Mutations in the IDUA gene have been found to
cause mucopolysaccharidosis type I (MIM 607014). This leads to the
accumulation of GAGs within lysosomes causing different organs to be
dysfunctional.
A clinical laboratory's experience using GeneMatcher -- building stronger gene-disease relationships.
Authors: Taylor Julie , Malhotra Alka , Burns Nicole , Clause Amanda , Brown Carolyn , Burns Brendan , Chandrasekhar Anjana , Schlachetzki Zina , Bennett Maren , Thorpe Erin , Taft Ryan , Perry Denise , Coffey Alison
Published: October 2021

The use of whole-genome sequencing (WGS) has accelerated the pace of
gene discovery and highlighted the need for open and collaborative data
sharing in the search for novel disease genes and variants. GeneMatcher
(GM) is designed to facilitate connections between researchers,
clinicians, health-care providers and others to help in the
identification of additional patients with variants in the same
candidate disease genes. The Illumina Clinical Services Laboratory
offers a WGS test for patients with suspected rare and undiagnosed
genetic disease and regularly submits potential candidate genes to GM to
strengthen gene-disease relationships. We describe our experience with
GM, including criteria for evaluation of candidate genes, and our
workflow for the submission and review process. We have made 69
submissions, 36 of which are currently active. Ten per cent of
submissions have resulted in publications, with an additional 14
submissions part of ongoing collaborations and expected to result in a
publication.
Evaluation and attribution analysis of land degradation and development in Hainan Island, China
Authors: Wu Wenyin , Yu Jianan , He Bohao , Jiang Yamin , Su Tianyan , Li Ruonan , Shen Xiaowen , Liu Wenjie
Published: October 2021

Studies on land degradation and development (LDD) and the underlying
factors can help land restoration. In this study, the LDD of Hainan
Island from 2000 to 2018 were measured by change vector analysis using
the normalised difference vegetation index and net primary productivity
(NPP). The underlying factors of LDD were selected from seven potential
factors (nature factors: mean annual temperature, mean annual drought
intensity, human disturbances: gross domestic product (GDP), population,
population urbanisation, accumulated afforestation area, construction
area) based on structural equation modelling. The results showed that 1)
the degree of land-use changes into water area and construction land
were higher than for the other land-use types; 2) Compared to 2000, the
most serious degradation occurred in 2015, which accounting for 68.98%
of the total land degradation as well as more than three-quarters of the
land degradation in all surveyed years was driven by NPP; 3) The
proportion of land degradation (PLD) was negatively correlated with the
mean value of the land degradation and development (MLDD) in the period
of five years, 2000-2018 (P<0.01); 4) The key influencing
factors of PLD were temperature, accumulated afforestation area,
population urbanisation, in 2000–2005, 2005–2010 and 2010–2018,
respectively; 5) The key influencing factors of MLDD were temperature,
GDP, population urbanisation, in 2000–2005, in 2005–2010 and in
2010–2018, respectively. Therefore, to minimise land degradation it is
necessary to limit the speed of population urbanisation occurs and to
improve the island environment’s adaptability to extreme climates.
Fetal surveillance from 39 weeks’ gestation: an alternative to earlier induction of labour to reduce stillbirth in South Asian born women? A Retrospective Cohort Study
Authors: Davies-Tuck Miranda , Davey Mary-Ann , Hodges Ryan , Wallace Euan
Published: October 2021

Objectives: In July 2017, Victoria’s largest maternity service
implemented a new clinical guideline aimed to reduce the rates of
stillbirth at term for South Asian-born women. Here we present the
evaluation of the change in care on rates of stillbirth, neonatal and
obstetric interventions. Design: Cohort Study Setting: Victoria’s
largest metropolitan university-affiliated teaching hospital.
Population: All women receiving antenatal care who gave birth in the
term period between January 2016 and December 2020. Methods: Differences
in rates of stillbirths, neonatal deaths, perinatal morbidities, and
interventions after July 2017 were determined. Multigroup interrupted
time-series analysis was used to assess changes in rates of induction of
labour. Main Outcome Measures: Rates of stillbirths, neonatal deaths,
perinatal morbidities, and obstetric interventions. Results: 3506 south
Asian-born women gave birth prior to, and 8532 after the change. There
was a 64% reduction in term stillbirth (95%CI 87% to 2%; p=0.047)
for south Asian-born women after the change in practice from 2.3 per
1000 births to 0.8 per 1000 births. The rates of early neonatal death
(3.1 per 1000 vs 1.3 per 1000; p=0.03) and SCN admission (16.5% vs
11.1%; p<0.001) also decreased. There were no significant
differences in admission to NICU, Apgar<7 at 5 minutes,
birthweight or differences in the trends of induction of labour per
month. Conclusions: Fetal monitoring from 39 weeks’ may offer an
alternative to routine earlier induction of labour to reduce the rates
of stillbirth without causing an increase in neonatal morbidity or
obstetric interventions.
Development of FEM - programs for modeling the synthesis of anisotropic materials by powder metallurgy with electric heating
Authors: Turygina Victoria , Sachkov Igor , Ford Vitaly
Published: October 2021

A computer program has been created that makes it possible to analyze
the features of the spatial distribution of Joule heat in two-phase
matrix systems with round inclusions. The program uses the finite
element method and is implemented in Fortran code. It was found that at
certain points of the two-phase medium, the specific power of the Joule
heat is determined. The magnitude of the unevenness of the heat
distribution exhibits the ability to level. It was found that the
location of the points at which the set parameters for a given structure
pm are set depends on the ratio between the conduction of the matrix and
the inclusion and the local mutual arrangement of the inclusions. The
processes of sintering powder materials using electric heating are
considered. It was found that as a result of selective sedimentation,
the possibility of the formation of anisotropic structures is turned on.
The features of the processes of contact electrical materials based on
mixtures of copper and tungsten are discussed. It is assumed that the
processes of local heating can initiate the sedimentation of copper
particles. In this case, groupings of particles can be formed, oriented
along the direction of the heating electric current. The possibility of
synthesizing materials similar to composite fiber systems is shown. It
is proposed to use computer simulation programs to support heat
treatment processes using electric heating.
Genome Editing accelerated Re-Domestication” (GEaReD) – a new major direction in plant breeding
Authors: Hanak Tobias , Madsen Claus , Brinch-Pedersen Henrik
Published: October 2021

The effects of climate change, soil depletion, a growing world
population putting pressure on food safety and security are major
challenges for agriculture in the 21st century. The breeding success of
the green revolution has decelerated and current programs can only
offset the yield affecting factors. New approaches are urgently needed
and we propose, “Genome Editing accelerated Re-Domestication” (GEaReD)
as a major new direction in plant breeding. By combining the upcoming
technologies for phenotyping, omics and artificial intelligence with the
promising new CRISPR-toolkits, this approach is closer than ever. Wild
relatives of current crops are often adapted to harsh environments and
have a high genetic diversity. Re-domestication of wild barley or
teosinte could generate new cultivars adapted to environmental changes.
De novo domestication of perennial relatives like Hordeum bulbosum could
counter with soil depletion and increase soil carbon. Recent research
already proved the principle of re-domestication in tomato and rice and
therefore laid the foundation for GEaReD.
Epidemiological features of healthcare associated infections in pediatric cardiac surgery
Authors: Nabieva A. S. , Aslanov B. I. , Timchenko V. N. , Ponomarev N. A.
Published: October 2021

4—5 congenital heart defect cases per 1000 newborns are diagnosed worldwide. Some malformations require surgical methods of correction. Various risk factors contribute to the development of healthcare associated infections (HAIs). The HAIs are one of the leading causes of the prolongation of hospitalization length both in intensive care unit and in the inpatient departments, and they also play a significant role in increasing the number of lethal outcomes. A number of risk factors play an important role in the development of HAIs: the duration of post-operative mechanical ventilation, neonatal age, low birth weight, co-morbidities, including malformations of other body systems.
Metacognition and Self-determination, Impulsivity and Emotional intelligence, and its relation with wellbeing and health indicators in young adults
Authors: Castro Muñoz John Alexander , Hernández-Pozo María del Rocío , Barahona Torres Igor
Published: October 2021

Background: From the evidence, it is inferred the influence of cognitive or motivational variables over the emotional ones and from these on the perception and self-reported wellbeing and health, with direct implications for health promotion and prevention. Method: a quantitative approach, descriptive, correlational cross-sectional with statistical explanatory analysis investigation was conducted, analyzing the data through path modeling of the partial least squares approach of the structural equations model, by using the Smart PLS software 3.3.2 version, analyzing consequently the convergent and discriminant validity of the model. A total 223 undergraduate university young adult students was evaluated, 41 men (18,4%) and 182 women (81,6%) with ages between 18 and 30 years old (µ= 24,26 y σ=±3,30), from Bogotá Colombia participated. Results: The results allowed to significant relations between the self – determination with the impulsivity and emotional intelligence, and from these with the psychological well-being and healthy habits. There were not identified significant relations between the metacognition and the impulsivity, although there are between metacognition and emotional intelligence. Conclusions: The proposed model about the significant relations between metacognition and self-determination with impulsivity and emotional intelligence and between these and the psychological well-being and healthy habits was confirmed. The specific result related to the absence of significant relations between metacognition and the impulsivity suggest for futures research, to emphasize on the metacognitive process implicated on the emotional components. The results are discussed, its implications and the necessity to be considered more determinants for the promotion of health.