bluuebunny/crossref_metadata_2025 huggingface dataset:
Best constants in Sobolev and Gagliardo–Nirenberg inequalities on graded groups and ground states for higher order nonlinear subelliptic equations
Authors: Ruzhansky Michael , Tokmagambetov Niyaz , Yessirkegenov Nurgissa
Published: September 2020

In this paper the dependence of the best constants in Sobolev and Gagliardo–Nirenberg inequalities on the precise form of the Sobolev space norm is investigated. The analysis is carried out on general graded Lie groups, thus including the cases of$$\mathbb {R}^n$$Rn, Heisenberg, and general stratified Lie groups, in all these cases the results being new. The Sobolev norms may be defined in terms of Rockland operators, i.e. the hypoelliptic homogeneous left-invariant differential operators on the group. The best constants are expressed in the variational form as well as in terms of the ground state solutions of the corresponding nonlinear subelliptic equations. The orders of these equations can be high depending on the Sobolev space order in the Sobolev or Gagliardo–Nirenberg inequalities, or may be fractional. Applications are obtained also to equations with lower order terms given by different hypoelliptic operators. Already in the case of$${\mathbb {R}}^n$$Rn, the obtained results extend the classical relations by Weinstein (Commun Math Phys 87(4):567–576 (1982/1983)) to a wide range of nonlinear elliptic equations of high orders with elliptic low order terms and a wide range of interpolation inequalities of Gagliardo–Nirenberg type. However, the proofs are different from those in Weinstein (Commun Math Phys 87(4):567–576 (1982/1983)) because of the impossibility of using the rearrangement inequalities already in the setting of the Heisenberg group. The considered class of graded groups is the most general class of nilpotent Lie groups where one can still consider hypoelliptic homogeneous invariant differential operators and the corresponding subelliptic differential equations.
Cortical threaded pedicle screw improves fatigue strength in decreased bone quality
Authors: Weiser Lukas , Sellenschloh Kay , Püschel Klaus , Morlock Michael M. , Viezens Lennart , Lehmann Wolfgang , Huber Gerd
Published: September 2020

Purpose

Inadequate anchoring of pedicle screws in vertebrae with poor bone quality is a major problem in spine surgery. The aim was to evaluate whether a modified thread in the area of the pedicle could significantly improve the pedicle screw fatigue strength.

Methods

Fourteen human cadaveric vertebral bodies (L2 and L3) were used for in vitro testing. Bone density (BMD) was determined by quantitative computed tomography. Vertebral bodies were instrumented by standard pedicle screws with a constant double thread on the right pedicle and a partial doubling of the threads–quad thread–(cortical thread) in the area of the pedicle on the left pedicle. Pulsating sinusoidal, cyclic load (0.5 Hz) with increasing peak force (100 N + 0.1 N/cycles) was applied orthogonal to the screw axis. The baseline force remained constant (50 N). Fatigue test was terminated after exceeding 5.4-mm head displacement (~ 20° screw tilting).

Results

The mean fatigue load at failure was 264.9 N (1682 cycles) for the standard screws and was increased significantly to 324.7 N (2285 cycles) by the use of cortical threaded screws (p = 0.014). This effect is particularly evident in reduced BMD (standard thread 241.2 N vs. cortical thread 328.4 N; p = 0.016), whereas in the group of vertebrae with normal BMD no significant difference could be detected (standard thread 296.5 N vs. cortical thread 319.8 N; p = 0.463).

Conclusions

Compared to a conventional pedicle screw, the use of a cortical threaded pedicle screw promises superior fatigue load in vertebrae with reduced bone quality.
Reciprocal relationships between paternal psychological distress and child internalising and externalising difficulties from 3 to 14 years: a cross-lagged analysis
Authors: Sifaki Maria , Midouhas Emily , Papachristou Efstathios , Flouri Eirini
Published: September 2020

Research shows that paternal psychological distress is associated with child emotional and behavioural difficulties. However, little is known about the direction of this association including whether it is bidirectional. The aim of this study was to explore the reciprocal relationships between paternal psychological distress and child emotional and behavioural problems longitudinally (at ages 3, 5, 7, 11 and 14 years) in a sample of 13,105 children (49% girls) who participated in the UK’s Millennium Cohort Study (MCS), a large-scale, nationally representative, longitudinal survey. Four domains of child problems (emotional symptoms, peer relations, conduct problems and hyperactivity/inattention) were measured with the Strengths and Difficulties Questionnaire and paternal psychological distress was measured with the Kessler K-6 scale. Data were analysed using cross-lagged path models. At all ages, paternal psychological distress predicted both subsequent child emotional symptoms as well as peer problems. Paternal psychological distress at child’s age 3 was related to more hyperactivity at age 5 and, at age 5, paternal psychological distress was associated with more conduct problems at age 7. At age 11, paternal distress was also related to age 14 conduct problems and hyperactivity. Child effects were fewer and were found mainly for behavioural problems. Notably, we found bidirectional links between paternal psychological distress and child peer difficulties, from 11 to 14 years. Paternal psychological distress appears to influence child behaviour more consistently than the converse. However, in early adolescence, there appears to be a reciprocal relationship between fathers’ mental health problems and children’s peer problems.
Clinical potential of hemodynamic ramp test by simultaneous echocardiography and right heart catheterization for aortic insufficiency in a patient with continuous-flow left ventricular assist device
Authors: Sujino Yasumori , Kuroda Kensuke , Yoshitake Koichi , Yagi Nobuichiro , Anegawa Eiji , Mochizuki Hiroki , Iwasaki Keiichiro , Nakajima Seiko , Watanabe Takuya , Yanase Masanobu , Fukushima Satsuki , Fujita Tomoyuki , Kobayashi Junjiro , Fukushima Norihide
Published: September 2020

Aortic insufficiency (AI) is an important adverse event in patients with continuous-flow (CF) left ventricular assist device (LVAD) support. AI is often progressive, resulting in elevated 2-year morbidity and mortality. The effectiveness of echocardiographic ramp studies in patients with AI has been unclear. Here, we describe a patient with a CF-LVAD implant who underwent aortic valve replacement (AVR), following assessment of AI using a hemodynamic ramp test with simultaneous echocardiography and right heart catheterization (RHC). The patient was a 21-year-old man with cardiogenic shock due to acute myocarditis, who underwent HeartWare CF-LVAD (HVAD) implantation. Heart failure persisted despite increased doses of diuretics and inotrope, as well as an increased HVAD pump rate. HVAD monitoring revealed a correlation between increased HVAD pump rate and flow at each speed step. A hemodynamic ramp test with simultaneous transthoracic echocardiography and RHC revealed a significant discrepancy between HVAD pump flow and cardiac output (CO) at each speed step; moreover, pulmonary capillary wedge pressure remained high. Therefore, the patient underwent AVR. Subsequently, his low CO symptoms disappeared and inotropes were successfully discontinued. A postoperative hemodynamic ramp test revealed that AVR had successfully closed the loop of blood flow and reduced the discrepancy between HVAD pump flow and CO, thereby increasing CO. The patient was then discharged uneventfully. In conclusion, a hemodynamic ramp test with simultaneous echocardiography and RHC was useful for the evaluation of the causal relationship between AI and low CO, and for selection of surgical treatment for AI in a patient with CF-LVAD.
Southern sustainability initiatives in agricultural value chains: a question of enhanced inclusiveness? The case of Trustea in India
Authors: Bitzer Verena , Marazzi Alessia
Published: September 2020

Recent studies have shed light on the emergence of Southern sustainability initiatives in commodity-based value chains. These initiatives position themselves as countering the exclusionary nature of many global multi-stakeholder initiatives (MSIs), as critically analysed by previous studies. However, a common theoretical perspective on the inclusiveness of MSIs is still lacking. By drawing on the theory of regimes of engagement, we develop a theoretical framework which helps understanding the overt and subtle practices of including or excluding different stakeholders in MSIs. We apply this framework to ‘Trustea’, an Indian MSI for sustainable tea production, to further investigate the ‘inclusiveness paradigm’ of Southern sustainability initiatives. Our findings highlight the complexity of stakeholder engagement across the different phases of Trustea’s development, from initiation and code development to formal launch and roll-out. We find that different types of engagement can exist in parallel. Justifiable engagement is expressed in the participating organisations’ reference to a shared common goal of Trustea, whereas familiar engagement is linked to the rootedness of the individuals involved in the Indian tea industry. Strategic engagement, in turn, comes to the fore through the strong emphasis on developing an Indian code for sustainable tea production and promoting adoption among tea growers. The importance of reaching this objective has led to the replication of exclusionary patterns also noted for global MSIs, as small-scale producers and other weak actors have been largely excluded from decision-making processes, despite informal efforts aimed at substitution of representation.
On the Nature of Coincidental Events
Authors: Melas Alessandra , Salis Pietro
Published: September 2020

It is a common opinion that chance events cannot be understood in causal terms. Conversely, according to a causal view of chance, intersections between independent causal chains originate accidental events, called “coincidences.” The present paper takes into proper consideration this causal conception of chance and tries to shed new light on it. More precisely, starting from Hart and Honoré’s view of coincidental events (Hart and Honoré in  Causation in the Law. Clarendon Press, Oxford, 1959), this paper furnishes a more detailed account on the nature of coincidences, according to which coincidental events are hybrids constituted by ontic (physical) components, that is the intersections between independent causal chains, plus epistemic aspects; where by “epistemic” we mean what is related, in some sense, to knowledge: for example, access to information, but also expectations, relevance, significance, that is psychological aspects. In particular, this paper investigates the role of the epistemic aspects in our understanding of what coincidences are. In fact, although the independence between the causal lines involved plays a crucial role in understanding coincidental events, that condition results to be insufficient to give a satisfactory definition of coincidences. The main target of the present work is to show that the epistemic aspects of coincidences are, together with the independence between the intersecting causal chains, a constitutive part of coincidental phenomena. Many examples are offered throughout this paper to enforce this idea. This conception, despite—for example—Antoine Augustine Cournot and Jacques Monod’s view, entails that a pure objectivist view about coincidences is not tenable.
Myocardial involvement and deformation abnormalities in idiopathic inflammatory myopathy assessed by CMR feature tracking
Authors: Kersten Johannes , Güleroglu Ahmet Muhammed , Rosenbohm Angela , Buckert Dominik , Ludolph Albert Christian , Hackenbroch Carsten , Beer Meinrad , Bernhardt Peter
Published: September 2020

Background

Cardiac involvement has been described in idiopathic inflammatory myopathies (IIM), including non-specific ECG and echocardiographic findings. Aim of our study was to evaluate myocardial deformation parameters in IIM and to correlate them with late gadolinium enhancement (LGE) findings using cardiac magnetic resonance imaging (CMR).

Methods

Forty-seven consecutive patients with histologically proven IIM were included into our study. Twenty-five healthy volunteers were used as a control group. All patients and controls underwent CMR examination using a 1.5 T scanner including functional cine and LGE imaging. After a mean follow-up of 234.7 ± 79.5 days a second CMR examination was performed in IIM patients.

Results

In comparison to healthy volunteers, IIM patients had lower left ventricular mass and left ventricular global radial, circumferential and longitudinal strain. There was no significant difference in left ventricular ejection fraction.

Patients with LGE (N = 28) had lower left ventricular ejection fraction (p = 0.016), global right and left ventricular longitudinal strain (p = 0.014 and p = 0.005) and global left ventricular diastolic longitudinal strain rate (p = 0.001) compared to patients without LGE (N = 19).

In IIM patients, a significant decrease of left ventricular ejection fraction, left ventricular mass and all measured deformation parameters was observed between baseline and follow-up CMR.

Conclusion

Cardiac involvement in IIM is frequent. Impairment of systolic and diastolic deformation parameters and a worsening over time can be observed. CMR is a useful tool for cardiac diagnostic work-up of these patients.
Raspberry bushy dwarf virus in Slovenia - geographic distribution, genetic diversity and population structure
Authors: Mavrič Pleško Irena , Lamovšek Janja , Lešnik Andreja , Viršček Marn Mojca
Published: September 2020

Raspberry bushy dwarf virus (RBDV) is a long-known virus naturally infecting Rubus and grapevine. It is also one of the economically most important viruses of raspberries, but there are only a limited number of sequences covering a substantial part of the genome available in the databases. The aim of this study was: i) to study the geographic distribution of RBDV in Slovenia, and ii) to sequence RNA2 of several red raspberry and grapevine RBDV isolates and study their phylogeny and population structure. Geographic distribution studies were performed over a period of 13 years in three wine-growing regions of Slovenia (Primorska, Podravje and Posavje). The highest incidence of RBDV was found in Podravje (58.8%) and the lowest in Primorska (5.1%). Big differences were observed between Vipavska dolina (10.2%) and three other wine-growing districts of Primorska region (0.4–1.2%). Almost complete RNA2 sequences were obtained for four red raspberry isolates and seven grapevine isolates. Additionally, only coat protein sequences were obtained for three red raspberry isolates. Phylogenetic and population diversity analyses were performed on all available RBDV sequences. Phylogenetic analysis has shown clear differences in sequences from Rubus and grapevine that form two highly supported clades. In RNA2 analysis additional two sub-clades were found in grapevine clade. Two major subclades were identified also in the Rubus clade with further differentiation within these subclades. Purifying or stabilizing selection was found to be acting on both, CP and MP genes while few codons were found to be under positive selection.
The Teaching of Ethics and the Moral Competence of Medical and Nursing Students
Authors: Martins Vera Sílvia Meireles , Santos Cristina Maria Nogueira Costa , Bataglia Patrícia Unger Raphael , Duarte Ivone Maria Resende Figueiredo
Published: September 2020

In a time marked by the development of innovative treatments in healthcare and the need for health professionals to deal with resulting ethical dilemmas in clinical practice, this study was developed to determine the influence of the bioethics teaching on the moral competence of medical and nursing students. The authors conduct a longitudinal study using the Moral Competence Test extended version before and after attending the ethics curricular unit, in three nursing schools and three medical schools of Portugal. In this questionnaire the participant is confronted with three ethical dilemmas (related to theft, euthanasia and the torture of a terrorist) and asked to evaluate arguments for and against the attitude of the main character (Worker, doctor and judge). For both nursing and medical students, C-score was lower after the attendance of the ethics curricular units, with a statistically significant decrease in the total score (from 21 to 19.5 on average; p = 0.046) for nursing students and a decrease not statistically significant for medical students (from 23.2 to 22 on average; p = 0.358). A multivariate analysis did not find any association between this decrease and gender, course, or age. The phenomenon of moral segmentation was observed, with better performance in the worker and judge dilemma, than in the doctor dilemma. These results highlight the need to reflect on the curricular strategies that can be implemented for health professionals to better develop moral competence and decision-making, allowing for the provision of humanized health care.
Genetic Advances in Autism
Authors: Thapar Anita , Rutter Michael
Published: September 2020

In the last 40 years, there has been a huge increase in autism genetics research and a rapidly growing number of discoveries. We now know autism is one of the most highly heritable disorders with negligible shared environmental contributions. Recent discoveries also show that rare variants of large effect size as well as small effect common gene variants all contribute to autism risk. These discoveries challenge traditional diagnostic boundaries and highlight huge heterogeneity in autism. In this review, we consider some of the key findings that are shaping current understanding of autism and what these discoveries mean for clinicians.
Synthesis of carbon-supported bimetallic palladium–iridium catalysts by microemulsion: characterization and electrocatalytic properties
Authors: Szumełda Tomasz , Drelinkiewicz Alicja , Kosydar Robert , Gurgul Jacek , Duraczyńska Dorota
Published: September 2020

Carbon (Vulcan XC-72)-supported bimetallic Pd–Ir catalysts with different Pd/Ir proportions (5–50 mol% Ir, 2 wt% Pd) were prepared by “water-in-oil” microemulsion method (w/o) using solutions of low (0.02 M, L series) and high concentration (0.2 M, H series) of the metals precursors (PdCl2 and IrCl3). The bimetallic particles were examined in terms of nanoscale phase properties (extent of Pd–Ir alloying, phase separation), surface composition (Pd and Ir fractions) and electrocatalytic performance for the formic acid oxidation reaction. Structural characterization was performed using XRD, SEM and HRTEM techniques. Electrochemical characterization allowed estimating the PdH formation ability and the surface composition of Pd–Ir particles what was confirmed by XPS data. The Pd–Ir nanoparticles of similar average size (ca. 4 nm), close to that of Ir (3.8 nm) and below that of Pd (6.2 nm) were formed regardless of the Pd/Ir proportion and the concentration of the metals precursors in the w/o. In contrast to the largely alloyed PdIr nanoparticles with the Pd-rich surface formed at low concentration of the metals precursors (0.02 M), the particles of almost closed surface and bulk Pd/Ir ratios composed mostly of randomly distributed single-phase domains were formed at high concentration (0.2 M). At the lowest bulk Ir content, 5 mol%, the particles have Ir-rich surface regardless of the preparation method. The catalytic studies involving formic acid electrooxidation reaction showed the activity enhancement for the L series catalysts with respect to monometallic Pd/C (twofold TOF increase) and H series counterparts. The Pd85Ir15/C catalyst of the Pd–Ir alloyed and the surface composition expressed by the Pd/Ir atomic ratio near to 6 displayed the highest activity which was 2.9-times higher relative to that of Pd.

Graphic abstract
Correction to: Development of a conceptual model and patient-reported outcome measures for assessing symptoms and functioning in patients with heart failure
Authors: Moshkovich Olga , Benjamin Katy , Hall Katie , Murphy Ryan , von Maltzahn Robyn , Gorsh Boris , Sikirica Vanja , Saini Rajnish , Sprecher Dennis
Published: September 2020

The article Development of a conceptual model and patient-reported outcome measures for assessing symptoms and functioning in patients with heart failure.
Functional impairment and disability among patients with migraine: evaluation of galcanezumab in a long-term, open-label study
Authors: Ford Janet H. , Stauffer Virginia L. , McAllister Peter , Akkala Sreelatha , Sexson Matthew , Ayer David W. , Wang Shufang
Published: September 2020

Purpose

Migraine can negatively impact patient functioning and quality of life. Here, we report the effects of galcanezumab (GMB), a humanized monoclonal antibody that binds to calcitonin gene-related peptide, on patient-reported outcome (PRO) measures in migraine.

Methods

CGAJ was a Phase III, randomized, open-label study (12-month open-label and 4-month post-treatment follow-up) in patients with episodic or chronic migraine. Patients aged 18–65 years with diagnosis of migraine (≥ 4 migraine headache days per month) as defined by International Classification of Headache Disorders (ICHD)-3 beta guidelines were included in the study. Patients were randomized 1:1 with subcutaneous GMB 120 mg (with a loading dose of 240 mg) or GMB 240 mg given once monthly for 12 months. Changes from baseline in PRO measures such as Migraine-Specific Quality of Life Questionnaire v2.1 (MSQ) and Migraine Disability Assessment (MIDAS) were assessed.

Results

A total of 135 patients were randomized to each galcanezumab dose group. Mean (SD) baseline MSQ total scores were 53.85 (20.34) [GMB 120 mg] and 53.69 (18.79) [GMB 240 mg]. For MIDAS, mean (SD) total scores were 45.77 (42.06) [GMB 120 mg] and 53.96 (61.24) [GMB 240 mg]. Within-group mean improvement from baseline on MSQ and MIDAS total scores and all individual item/domain scores were statistically significant for both GMB dose groups, at all-time points during the treatment phase (p < 0.001). For MSQ domain scores, greatest improvement was observed in the Role function-restrictive (RF-R) domain (overall least squares (LS) mean change ± SE: 31.55 ± 1.20 [GMB 120 mg] and 33.40 ± 1.16 [GMB 240 mg]). For MIDAS, the overall LS mean change ± SE from baseline across the entire 12-month treatment phase in total scores were: −33.58 ± 2.11 (GMB 120 mg) and −32.67 ± 2.04 (GMB 240 mg).

Conclusion

Galcanezumab was associated with statistically significant changes from baseline in the PRO measures across the entire 12-month treatment period. These results indicate improved health-related quality of life and decreased disability among patients treated with galcanezumab.
Risk and Equity Release Mortgages in the UK
Authors: Sharma Tripti , French Declan , McKillop Donal
Published: September 2020

Accessing elderly housing wealth through equity release mortgages (ERMs) continue to be the focus of policy debates about how to pay for social care and how to support retirement incomes in the UK. We demonstrate in this paper that the spatial concentration of this market in just a few regions is not due to demand but to the risks faced by suppliers. We show that by ignoring regional variations in No Negative Equity Guarantee risk in national pricing models providers cannot profitably supply these products outside areas of high house price growth. We also show that EU Solvency II capital requirements provide a further disincentive to supply ERMs in these areas. Government subsidies to product provision are also modelled and shown to be infeasibly high. We therefore conclude that the government policy focus on equity release as a means of tackling the challenges of an ageing population is misplaced.
Data identity and perspectivism
Authors: Jacoby Franklin
Published: September 2020

This paper uses several case studies to suggest that (1) two prominent definitions of data do not on their own capture how scientists use data and (2) a novel perspectival account of data is needed. It then outlines some key features of what this account could look like. Those prominent views, the relational and representational, do not fully capture what data are and how they function in science. The representational view is insensitive to the scientific context in which data are used. The relational account does not fully account for the empirical nature of data and how it is possible for data to be evidentially useful. The perspectival account surmounts these problems by accommodating a representational element to data. At the same time, data depend upon the epistemic context because they are the product of situated and informed judgements.
Understanding a communicated thought
Authors: Carter J. Adam , Gordon Emma C. , Grodniewicz J. P.
Published: September 2020

The goal of this paper is twofold. First, we argue that the understanding one has of a proposition or a propositional content of a representational vehicle is a species of what contemporary epistemologists characterise as objectual understanding. Second, we demonstrate that even though this type of understanding differs from linguistic understanding, in many instances of successful communication, these two types of understanding jointly contribute to understanding a communicated thought.
Investigation and modeling of odors release from membrane holes on daily overlay in a landfill and its impact on landfill odor control
Authors: Jiang Jun , Li Jianhua , Rtimi Sami
Published: September 2020

In the present work, we studied the NH3 and H2S odor fluxes between the exposed working area and the HDPE covering film holes of the daily overlay in an actual landfill site with a daily operating area of 1600 m2 in Hangzhou, China. We showed that the odors were released from the membrane pores and the average concentrations of NH3 and H2S release reached 109.6 ± 56.6 and 86.0 ± 31.1 mg/m2/s, respectively. These concentrations are 43.8 and 57.3 times the exposed working surface. Furthermore, mathematical modeling based on the total amount of odor release revealed that there was a linear positive correlation between the total odor amount and the landfill operation area. However, the maximum number of film holes allowed on the covering layer has nothing to do with the working area and exposed working time, which is mainly determined by the HDPE film width in terms of ensuring the deodorizing effect of the covering operation. If the HDPE film with a width of more than 4 m is used, the number of film holes allowed within 100 m is more than 8. Therefore, in order to reduce the odor, the appropriate film width should be selected according to the actual operating conditions such as the mechanical operation level at the time of welding, the design of the landfill site, and the operational norms. This study explores the effect of film hole quantity of the daily cover in the landfill on the odor release from the landfill, which can provide an important reference for the design, operation, and decision-making of the daily cover operation of the sanitary landfill.
Risk stratification of young adult survivors of cancer to estimate hospital morbidity burden: applicability of a pediatric therapy-based approach
Authors: Clements Christopher , Cromie Kirsten J. , Smith Lesley , Feltbower Richard G. , Hughes Nicola , Glaser Adam W.
Published: September 2020

Purpose

Children and young adults (CYA) are at risk of late morbidity following cancer treatment, with risk varying by disease type and treatment received. Risk-stratified levels of aftercare which stratify morbidity burden to inform the intensity of long-term follow-up care, are well established for survivors of cancer under the age of 18 years, utilizing the National Cancer Survivor Initiative (NCSI) approach. We investigated the applicability of risk-stratified levels of aftercare in predicting long-term morbidity in young adults (YA), aged 18–29 years.

Methods

Long-term CYA survivors followed-up at a regional center in the North of England were risk-stratified by disease and treatments received into one of three levels. These data were linked with local cancer registry and administrative health data (Hospital Episode Statistics), where hospital activity was used as a marker of late morbidity burden.

Results

Poisson modelling with incident rate ratios (IRR) demonstrated similar trends in hospital activity for childhood (CH) and YA cancer survivors across NCSI risk levels. NCSI levels independently predicted long-term hospitalization risk in both CH and YA survivors. Risk of hospitalization was significantly reduced for levels 1 (CH IRR 0.32 (95% CI 0.26–0.41), YA IRR 0.06 (95% CI 0.01–0.43)) and 2; CH IRR 0.46 (95% CI 0.42-0.50), YA IRR 0.49 (95% CI 0.37-0.50)), compared with level 3.

Conclusions

The NCSI pediatric late-effects risk stratification system can be effectively and safely applied to cancer patients aged 18–29, independent of ethnicity or socioeconomic position.

Implications for Cancer Survivors

To enhance quality of care and resource utilization, long-term aftercare of survivors of YA cancer can and should be risk stratified through adoption of approaches such as the NCSI risk-stratification model.
Retrospective analysis of endocarditis patients to investigate the eligibility for oral antibiotic treatment in routine daily practice
Authors: Vroon J. C. , Liesdek O. C. D. , Boel C. H. E. , Arends J. E. , Niessen F. A. , van Heusden H. C. , Cramer M. J. , van der Spoel T. I. G. , Chamuleau S. A. J.
Published: September 2020

Background

According to the current guidelines of the European Society of Cardiology, patients with left-sided infective endocarditis are treated with intravenous antibiotics for 4–6 weeks, leading to extensive hospital stay and high costs. Recently, the Partial Oral Treatment of Endocarditis (POET) trial suggested that partial oral treatment is effective and safe in selected patients. Here, we investigated if such patients are seen in our daily clinical practice.

Methods

We enrolled 119 adult patients diagnosed with left-sided infective endocarditis in a retrospective, observational study. We identified those that would be eligible for switching to partial oral antibiotic treatment as defined in the POET trial (e.g. stable clinical condition without signs of infection). Secondary objectives were to provide insight into the time until each patient was eligible for partial oral treatment, and to determine parameters of longer hospital stay and/or need for extended intravenous antibiotic treatment.

Results

Applying the POET selection criteria, the condition of 38 patients (32%) was stable enough to switch them to partial oral treatment, of which 18 (47.3%), 8 (21.1%), 9 (23.7%) and 3 patients (7.9%) were eligible for switching after 10, 14, 21 days or 28 days of intravenous treatment, respectively.

Conclusion

One-third of patients who presented with left-sided endocarditis in routine clinical practice were possible candidates for switching to partial oral treatment. This could have major implications for both the patient’s quality of life and healthcare costs. These results offer an interesting perspective for implementation of such a strategy, which should be accompanied by a prospective cost-effectiveness analysis.
Evaluating the effects of sewage sludge compost applications on the microbial activity, the nutrient and heavy metal content of a Chernozem soil in a field survey
Authors: Farsang Andrea , Babcsányi Izabella , Ladányi Zsuzsanna , Perei Katalin , Bodor Attila , Csányi Katalin Tímea , Barta Károly
Published: September 2020

Sewage sludge contains organic matter and micro and macronutrients which are potentially useful for agricultural usage. However, it can be harmful when containing undesirable amounts of organic pollutants, heavy metals, or pathogens. Our study focused on examining the changes in the extractable nutrient, organic matter and heavy metal contents of a Chernozem soil and the alteration of the soil biological activity as a consequence of low-dose municipal sewage sludge compost applications (0.5 t/ha). Sampling campaigns were done in 2018 near Újkígyós (SE Hungary) during which composite soil samples (0–30 cm and 30–60 cm) and groundwater samples were collected for assessing changes in the nutrient and heavy metal concentrations as a result of compost amendments’ use. Additionally, upper soil (0–50 cm) and subsoil (50–80 cm) were sampled for assessing biological parameters, considered to be aerobic and anaerobic soil layers, respectively. Soil samples were analyzed for the basic pedological parameters (pH, organic matter, carbonates and texture), nutrients (K2O, P2O5, N-forms and organic matter) and heavy metal concentrations following standard extraction procedures. The microbial properties were characterized by colony-forming units (CFUs) and enzyme activity measurements. The results of the nutrient analyses show significantly increased soil-bound K2O, P2O5 and NO2− + NO3− contents linked to the sewage sludge treatments. However, neither the organic matter nor the heavy metal content varied significantly in the sludge-amended soil compared with a control site. The microbiological analyses revealed that the sewage sludge treatments tended to increase the aerobic CFUs, but not that of the anaerobic microbes. The average catalase enzyme activity in both the aerobic and anaerobic samples and the average dehydrogenase activity only in the aerobic layers showed a slight but not significant increase in the compost-amended soils. Overall, these results convincingly demonstrated that amending soils with low doses of municipal sewage sludge composts (lacking any industrial sources) can be a sustainable fertilizing practice taking advantage of their high N, P and K contents that are slowly converted to their bioavailable forms thus preventing their excessive leaching in the groundwater.
E-commerce payment model using blockchain
Authors: Kim Shee-Ihn , Kim Seung-Hee
Published: September 2020

The current e-commerce payment systems for credit or check cards require a payment gateway (PG). This incurs PG fees, which in turn increases the cost of engaging in e-commerce. This paper proposes a simple payment model that uses basic cryptocurrency features, such as public key, private key, and digital signature, to eliminate the need for transaction intermediaries such as public key certificate and PG. This model can process e-commerce payments without registering additional public key certificate, public key, or private key. The use of a digital signature guarantees the integrity and nonrepudiation of electronic payments, besides eliminating the fees for intermediary services such as PG, thereby reducing the overall cost of operating e-commerce services. This proposal is crucial as it is the first attempt to apply blockchain technology to e-commerce payment services. In addition, our model is important because it not only supports the evolution of e-commerce payment technology but also enhances the competitive advantage of using e-commerce.
On atom-swarming and Luce’s theorem for probabilistic beliefs
Authors: Mackenzie Andrew
Published: September 2020

For qualitative probability spaces, monotone continuity and third-order atom-swarming are together sufficient for a unique countably additive probability measure representation that may have atoms (Mackenzie in Theor Econ 14:709–778, 2019). We provide a new proof by appealing to a theorem of Luce (Ann Math Stat 38:780–786, 1967), highlighting the usefulness of extensive measurement theory (Krantz et al. in Foundations of Measurement Volume I: Additive and Polynomial Representations. Academic Press, New York, 1971) for economists.
AGTR: Adversarial Generation of Target Review for Rating Prediction
Authors: Yu Huilin , Qian Tieyun , Liang Yile , Liu Bing
Published: September 2020

Recent years have witnessed a growing trend of utilizing reviews to improve the performance and interpretability of recommender systems. Almost all existing methods learn the latent representations from the user’s and the item’s historical reviews and then combine these two representations for rating prediction. The fatal limitation in these methods is that they are unable to utilize the most predictive review of the target user for the target item since such a review is not available at test time. In this paper, we propose a novel recommendation model, called AGTR, which cangenerate the unseen target review with adversarial training for rating prediction. To this end, we develop a unified framework to combinethe rating tailored generative adversarial netsfor synthetic review generation andthe neural latent factor moduleusing the generated target review along with historical reviews for rating prediction. Extensive experiments on four real-world datasets demonstrate that our model achieves the state-of-the-art performance in both rating prediction and review generation tasks.
Wittgenstein's Heirs and Editors
Authors: Erbacher Christian
Published: September 2020

Ludwig Wittgenstein is one of the most widely read philosophers of the twentieth century. But the books in which his philosophy was published – with the exception of his early work Tractatus Logico-Philosophicus – were posthumously edited from the writings he left to posterity. How did his 20,000 pages of philosophical writing become published volumes? Using extensive archival material, this Element reconstructs and examines the way in which Wittgenstein's writings were edited over more than fifty years, and shows how the published volumes tell a thrilling story of philosophical inheritance. The discussion ranges over the conflicts between the editors, their deviations from Wittgenstein's manuscripts, other scholarly issues which arose, and also the shared philosophical tradition of the editors, which animated their desire to be faithful to Wittgenstein and to make his writings both available and accessible. The Element can thus be read as a companion to all of Wittgenstein's published works of philosophy.
THE ROGERS–RAMANUJAN CONTINUED FRACTION AND RELATED ETA-QUOTIENT REPRESENTATIONS
Authors: CHERN SHANE , TANG DAZHAO
Published: September 2020

We construct eta-quotient representations of two families of q-series involving the Rogers–Ramanujan continued fraction by establishing related recurrence relations. We also display how these eta-quotient representations can be utilised to dissect certain q-series identities.
Analyzing cognitive processes of a product/service-system design session using protocol analysis
Authors: Sakao Tomohiko , Gero John , Mizuyama Hajime
Published: September 2020

Product/service systems (PSSs) are increasingly found in markets, and more resources are being invested in PSS design. Despite the substantial research into PSS design, the current literature exhibits an incomplete understanding of it as a cognitive activity. This article demonstrates that the methods used to analyze product designers’ cognitive behavior can be used to produce comparable and commensurable results when analyzing PSS designers. It also generates empirical grounding for the development of hypotheses based on a cognitive study of a PSS design session in a laboratory environment using protocol analysis. This study is a part of a larger project comparing PSS design with product design. The results, which are based on the function–behavior–structure coding scheme, show that PSS design, when coded using this scheme, can be quantitatively compared with product design. Five hypotheses were developed based on the results of the study of this design session concerning where and how designers expend their cognitive design effort. These hypotheses can be used to design experiments that test them and provide the grounding for a fuller understanding of PSS design.
Deutsche Psychologiestudierende in Österreich
Authors: Korunka Christian , Neubauer Aljoscha
Published: September 2020

Zusammenfassung. Nahezu die Hälfte der Studierenden an österreichischen psychologischen Instituten kommt aus dem Nachbarland Deutschland. Ein wesentlicher Grund dafür ist die dortige strenge Numerus Clausus-Selektion. Allerdings kehren viele dieser Studierenden nach einem Abschluss wieder in ihr Heimatland zurück, was zur Folge hat, dass Österreich zahlreiche Psycholog_innen für den deutschen Arbeitsmarkt ausbildet und mittelfristig vielleicht sogar ein Mangel an Psycholog_innen zu befürchten ist. Vor diesem Hintergrund untersucht die vorliegende Studie Heimkehr- und Bleibemotive deutscher Studierender in Österreich. 453 Absolvent_innen aus den letzten drei Jahren an vier Universitätsstandorten nahmen an der Studie teil. Die deutschen Studierenden weisen im Vergleich zu ihren Kolleg_innen aus Österreich eine höhere Erfolgsquote beim Aufnahmeverfahren, eine etwas geringere mittlere Studiendauer und einen besseren Gesamtnotenschnitt im Studium auf. Es können vier „Lebensmittelpunktgruppen“ nach Abschluss des Studiums gebildet werden, die sich deutlich in ihren Motiven zur Wahl des Lebensmittelpunkts unterscheiden. Familiäre Bindungen und bessere Karrieremöglichkeiten sind zentrale Motive für die Rückkehr nach Deutschland nach dem Studium, die regionalen Bindungen an Österreich bleiben meist eher gering.
The Evolving Distribution of Relative Humidity Conditional Upon Daily Maximum Temperature in a Warming Climate
Authors: Yuan Jiacan , Stein Michael L. , Kopp Robert E.
Published: September 2020

The impacts of heat waves in a warming climate depend not only on changing temperatures but also on changing humidity. Using 35 simulations from the Community Earth System Model Large Ensemble (CESM LENS), we investigate the long‐term evolution of the joint distribution of summer relative humidity (RH) and daily maximum temperature (Tmax) near four U.S. cities (New York City, Chicago, Phoenix, and New Orleans) under the high‐emissions Representative Concentration Pathway (RCP) 8.5. We estimate the conditional quantiles of RH given Tmax with quantile regression models, using functions of temperature for each city in July for three time periods (1990–2005, 2026–2035, and 2071–2080). Quality‐of‐fit diagnostics indicate that these models accurately estimate conditional quantiles for each city. As expected, each quantile of Tmax increases from 1990–2005 to 2071–2080, while mean RH decreases modestly. Conditional upon a fixed quantile of Tmax, the median and high quantiles of RH decrease, while those of the Heat Index (HI) and dew point both increase. This result suggests that, despite a modest decrease in median relative humidity, heat stress measured by metrics considering both humidity and temperature in a warming climate will increase faster than that measured by temperatures alone would indicate. For a fixed Tmax, the high quantiles of RH (and thus of HI and dew point) increase from 1990–2005 to 2071–2080 in all four cities. This result suggests that the heat stress of a day at a given Tmax will increase in a warming climate due to the increase of RH.
UAVSAR Tomography for Vertical Profile Generation of Tropical Forest of Mondah National Park, Gabon
Authors: Asopa Udit , Kumar Shashi
Published: September 2020

Polarimetric synthetic‐aperture radar (SAR) remote sensing has been widely used for structural and biophysical parameters retrieval of forest vegetation. It has been found that the combination of polarimetric properties and interferometric characteristics of SAR remote sensing provides the capacity to retrieve forest height. The prime objective of this research was to investigate the potential of Polarimetric Synthetic Aperture Radar Tomography (PolTomSAR) for the forested and river region of Mondah National Park, Gabon. SAR tomography is an improved method for acquiring the height of geographical features. UAVSAR L‐band fully polarimetric multibaseline data have been used in this research (1.275 GHz). SAR data and ground data over the area have been collected in the year 2016. With the superresolution‐based Capon algorithm, multiple scatterers located at a different vertical position in the same azimuth range cell has been resolved and reconstructed. This work provides a framework for Capon‐based tomographic processing of multibaseline UAVSAR data for vertical profile retrieval of forest vegetation. The height profile of the forest patch having sparse, as well as dense vegetation, were retrieved. The vertical profile for a single azimuthal bin was obtained in range direction. The tomographic profile obtained was cross‐checked with the field‐measured forest height for the 16 locations in Mondah National Park, Gabon. To check the accuracy of the applied method, the statistical method of R2 and root‐mean‐square error (RMSE) is employed. The obtained RMSE of the result is 4.21 m and R2 is 0.92. The obtained results were concluded to find the potential of the Capon algorithm for the tomographic reconstruction of UAVSAR data.
Trans-Atlantic Dusts May Not Enrich Amazon as Much as Thought
Authors: Shultz David
Published: September 2020

New research indicates that nutrient loads delivered to South American ecosystems by dust originating in Africa are far lower than suggested in previous studies.
Thomas Receives 2019 Basu U.S. Early Career Award for Research Excellence in Sun–Earth Systems Science
Authors:   AGU
Published: September 2020

Evan G. Thomas received the 2019 Basu U.S. Early Career Award for Research Excellence in Sun–Earth Systems Science at AGU’s Fall Meeting 2019, held 9–13 December in San Francisco, Calif. The award is given annually to one early career scientist (no more than 3 years postdegree) from the United States in recognition of “significant work that shows promise of making outstanding contributions to research in Sun–Earth systems science and furthers the understanding of plasma physical processes and their applications for the benefit of society.”
Maurya Receives 2019 Sunanda and Santimay Basu International Early Career Award in Sun–Earth Systems Science
Authors:   AGU
Published: September 2020

Ajeet Kumar Maurya received the 2019 Sunanda and Santimay Basu International Early Career Award in Sun–Earth Systems Science at AGU’s Fall Meeting 2019, held 9–13 December in San Francisco, Calif. The award recognizes “work that shows promise of making outstanding contributions to research in Sun–Earth systems science and furthers the understanding of plasma physical processes and their applications for the benefit of society.”
The First 10 Million Years of Rear‐Arc Magmas Following Backarc Basin Formation Behind the Izu Arc
Authors: Miyazaki T. , Gill J. B. , Hamelin C. , DeBari S. M. , Sato T. , Tamura Y. , Kimura J.‐I. , Vaglarov B. S. , Chang Q. , Senda R. , Haraguchi S.
Published: September 2020

IODP Site U1437 is located in the Izu rear‐arc region, approximately 330 km west of the Izu‐Bonin trench axis. The oldest four units (Units IV through Unit VII) include volcaniclastic sediment and in situ hyaloclastites. They have ages of about 6–15 Ma, shortly after cessation of Shikoku backarc basin opening. Three magma types are identified by their distinct geochemistry; they are similar types to those found in the modern Izu arc (Rear Arc Seamount Chain [RASC]‐type, Rift‐type, and volcanic front [VF]‐type). RASC‐type has the most enriched Nd and Hf isotope and fluid‐immobile trace element ratios and dominates from 9 to 6 Ma. Rift‐type, dominant from 15 to 9 Ma, is similar to VF‐type in Nd‐Hf isotopes but has the least radiogenic Sr and Pb, and intermediate La/Yb and Nb/Yb, indicating a more fertile mantle source and less hydrous slab component than VF‐type. Less common and randomly distributed VF‐type sediments have the most radiogenic Sr and Pb, and the highest Ba/(Th, LREE [light rare earth element]) ratios, and are interpreted to be distally derived. The genesis of mafic Unit VII samples (~15 Ma) was modeled using the Arc Basalt Simulator. Results are most similar to those for basalts in the modern rift environment indicating the addition of ~1% of a melt‐rich slab component generated at ~125 km, to a Philippine Sea Plate ambient mantle that was more depleted than DMM (depleted MORB mantle). The initial post‐Shikoku basin magmatism in the Izu rear‐arc generated Rift‐type magmas for about 6 million years before the distinctive RASC‐type magmatism began, which then became increasingly enriched.