bluuebunny/crossref_metadata_2025 huggingface dataset:
Store-Operated Ca2+ Entry Contributes to Piezo1-Induced Ca2+ Increase in Human Endometrial Stem Cells
Authors: Chubinskiy-Nadezhdin Vladislav , Semenova Svetlana , Vasileva Valeria , Shatrova Alla , Pugovkina Natalia , Negulyaev Yuri
Published: March 2022

Endometrial mesenchymal stem cells (eMSCs) are a specific class of stromal cells which have the capability to migrate, develop and differentiate into different types of cells such as adipocytes, osteocytes or chondrocytes. It is this unique plasticity that makes the eMSCs significant for cellular therapy and regenerative medicine. Stem cells choose their way of development by analyzing the extracellular and intracellular signals generated by a mechanical force from the microenvironment. Mechanosensitive channels are part of the cellular toolkit that feels the mechanical environment and can transduce mechanical stimuli to intracellular signaling pathways. Here, we identify previously recorded, mechanosensitive (MS), stretch-activated channels as Piezo1 proteins in the plasma membrane of eMSCs. Piezo1 activity triggered by the channel agonist Yoda1 elicits influx of Ca2+, a known modulator of cytoskeleton reorganization and cell motility. We found that store-operated Ca2+ entry (SOCE) formed by Ca2+-selective channel ORAI1 and Ca2+ sensors STIM1/STIM2 contributes to Piezo1-induced Ca2+ influx in eMSCs. Particularly, the Yoda1-induced increase in intracellular Ca2+ ([Ca2+]i) is partially abolished by 2-APB, a well-known inhibitor of SOCE. Flow cytometry analysis and wound healing assay showed that long-term activation of Piezo1 or SOCE does not have a cytotoxic effect on eMSCs but suppresses their migratory capacity and the rate of cell proliferation. We propose that the Piezo1 and SOCE are both important determinants in [Ca2+]i regulation, which critically affects the migratory activity of eMSCs and, therefore, could influence the regenerative potential of these cells.
Use of Melatonin in Cancer Treatment: Where Are We?
Authors: Wang Leilei , Wang Chuan , Choi Wing Shan
Published: March 2022

Cancer represents a large group of diseases accounting for nearly 10 million deaths each year. Various treatment strategies, including surgical resection combined with chemotherapy, radiotherapy, and immunotherapy, have been applied for cancer treatment. However, the outcomes remain largely unsatisfying. Melatonin, as an endogenous hormone, is associated with the circadian rhythm moderation. Many physiological functions of melatonin besides sleep–wake cycle control have been identified, such as antioxidant, immunomodulation, and anti-inflammation. In recent years, an increasing number of studies have described the anticancer effects of melatonin. This has drawn our attention to the potential usage of melatonin for cancer treatment in the clinical setting, although huge obstacles still exist before its wide clinical administration is accepted. The exact mechanisms behind its anticancer effects remain unclear, and the specific characters impede its in vivo investigation. In this review, we will summarize the latest advances in melatonin studies, including its chemical properties, the possible mechanisms for its anticancer effects, and the ongoing clinical trials. Importantly, challenges for the clinical application of melatonin will be discussed, accompanied with our perspectives on its future development. Finally, obstacles and perspectives of using melatonin for cancer treatment will be proposed. The present article will provide a comprehensive foundation for applying melatonin as a preventive and therapeutic agent for cancer treatment.
A Low Dose of Pure Cannabidiol Is Sufficient to Stimulate the Cytotoxic Function of CIK Cells without Exerting the Downstream Mediators in Pancreatic Cancer Cells
Authors: Garofano Francesca , Sharma Amit , Abken Hinrich , Gonzalez-Carmona Maria A. , Schmidt-Wolf Ingo G. H.
Published: March 2022

Despite numerous studies conducted over the past decade, the exact role of the cannabinoid system in cancer development remains unclear. Though research has focused on two cannabinoid receptors (CB1, CB2) activated by most cannabinoids, CB2 holds greater attention due to its expression in cells of the immune system. In particular, cytokine-induced killer cells (CIKs), which are pivotal cytotoxic immunological effector cells, express a high-level of CB2 receptors. Herein, we sought to investigate whether inducing CIK cells with cannabidiol can enhance their cytotoxicity and if there are any possible counter effects in its downstream cascade of phosphorylated p38 and CREB using a pancreatic ductal adenocarcinoma cell line (PANC-1). Our results showed that IL-2 modulates primarily the expression of the CB2 receptor on CIK cells used during ex vivo CIK expansion. The autophagosomal-associated scaffold protein p62 was found to co-localize with CB2 receptors in CIK cells and the PANC-1 cell line. CIK cells showed a low level of intracellular phospho-p38 and, when stimulated with cannabidiol (CBD), a donor specific variability in phospho-CREB. CBD significantly decreases the viability of PANC-1 cells presumably by increasing the cytotoxicity of CIK cells. Taken together, in our preclinical in vitro study, we propose that a low effective dose of CBD is sufficient to stimulate the cytotoxic function of CIK without exerting any associated mediator. Thus, the combinatorial approach of non-psychoactive CBD and CIK cells appears to be safe and can be considered for a clinical perspective in pancreatic cancer.
Adsorption Characteristics and Enrichment of Emodin from Marine-Derived Aspergillus flavipes HN4-13 Extract by Macroporous Resin XAD-16
Authors: Gong Lizhi , Wu Yuzhen , Qiu Xiaohan , Xin Xiujuan , An Faliang , Guo Miaomiao
Published: March 2022

Emodin, a hydroxyanthraquinone derivative, has been used as medicine for more than 2000 years due to its extensive pharmacological activities. Large-scale production of emodin has been achieved by optimizing the fermentation conditions of marine-derived Aspergillus flavus HN4-13 in a previous study. However, the fermentation broth contained complex unknown components, which adversely affected the study of emodin. Herein, the conditions for the enrichment of emodin from A. flavipes HN4-13 extract using XAD-16 resin were optimized, and a separation method with high efficiency, simple operation, a low cost, and a large preparative scale was established. The adsorption process of emodin on the XAD-16 resin conformed to pseudo-second-order kinetics and Langmuir models. The optimal conditions for the adsorption process were as follows: An emodin concentration, flow rate, and loading volume of 0.112 mg/mL, 2 BV/h, and 10 BV, respectively. For desorption, 50% ethanol was used to elute impurities and 80% ethanol was used to desorb emodin. After enrichment with XAD-16 resin, the emodin content increased from 1.16% to 11.48%, and the recovery rate was 75.53% after one-step treatment. These results demonstrate the efficiency of the simple adsorption–desorption strategy, using the XAD-16 resin for emodin enrichment.
Skeleton-Based Spatio-Temporal U-Network for 3D Human Pose Estimation in Video
Authors: Li Weiwei , Du Rong , Chen Shudong
Published: March 2022

Despite the great progress in 3D pose estimation from videos, there is still a lack of effective means to extract spatio-temporal features of different granularity from complex dynamic skeleton sequences. To tackle this problem, we propose a novel, skeleton-based spatio-temporal U-Net(STUNet) scheme to deal with spatio-temporal features in multiple scales for 3D human pose estimation in video. The proposed STUNet architecture consists of a cascade structure of semantic graph convolution layers and structural temporal dilated convolution layers, progressively extracting and fusing the spatio-temporal semantic features from fine-grained to coarse-grained. This U-shaped network achieves scale compression and feature squeezing by downscaling and upscaling, while abstracting multi-resolution spatio-temporal dependencies through skip connections. Experiments demonstrate that our model effectively captures comprehensive spatio-temporal features in multiple scales and achieves substantial improvements over mainstream methods on real-world datasets.
Threshold Uniformity Improvement in 1b Quanta Image Sensor Readout Circuit
Authors: Yin Zhaoyang , Ma Jiaju , Masoodian Saleh , Fossum Eric R.
Published: March 2022

A new readout architecture for single-bit quanta image sensor (QIS) consisting of a capacitive transimpedance amplifier (CTIA) before a 1-bit quantizer to improve the threshold uniformity of the readout cluster is proposed in this paper. The 1-bit quantizer in the previous single-bit QIS had significant threshold non-uniformity likely caused by the fluctuation of the common-mode voltage of the jot output. To guarantee the stability of the common-mode voltage of input signals fed to the 1-bit quantizer, the CTIA is added before the 1-bit quantizer. A pipeline operation mode is also proposed so the CTIA and 1-bit ADC can work at the same time, thereby reducing the CTIA power consumption. A 2048 × 1024 high-speed test chip was implemented with 45 nm/65 nm stacked backside illuminated (BSI) CMOS image sensor (CIS) process and tested. According to the measured D-log-H results, a good threshold uniformity in the range of 0.3 to 0.8 e− for all readout clusters is demonstrated at 500 frame per second (fps) equivalent timing with 68 mW power consumption.
Identification of Activation Isotopes in a CS-30 Cyclotron Vault
Authors: Abuhoza Alhussain A. , Kassim Hamoud A. , Alghamdi Ahmed A. , Alrumayan Faisal M. , Arib Mehenna , Aljammaz Ibrahim J. , ALQahtani Meshari
Published: March 2022

A CS-30 cyclotron has been in operation at King Faisal Specialist Hospital and Research Center (KFSHRC) since 1982. The CS-30 cyclotron has been used to produce medical radioisotopes for positron emission tomography (PET) and single-photon emission computed tomography (SPECT). Some of the nuclear reactions of radionuclide production are associated with the intense release of a wide range of fast neutrons. In this work, we investigated the radionuclides produced from neutron interactions with the cyclotron facility walls. Activation isotopes were determined by performing gamma ray spectrometry utilizing a high-purity germanium (HPGe) detector. The major radionuclides found were 152Eu, 154Eu, 134Cs, 65Zn and 60Co. Activation isotope accumulation had increased the dose rate inside the facility. The surface dose rates were measured at all of the surrounding walls. The maximum surface dose rate was found to be 1.2 µSv/h, which is much lower than the permissible occupational exposure of 15 µSv/h based daily 5 work hours.
Singular Spectrum Analysis for Modal Estimation from Stationary Response Only
Authors: Lin Chang-Sheng , Wu Yi-Xiu
Published: March 2022

Conventional experimental modal analysis uses excitation and response information to estimate the frequency response function. However, many engineering structures face excitation signals that are difficult to measure, so output-only modal estimation is an important issue. In this paper, singular spectrum analysis is employed to construct a Hankel matrix of appropriate dimensions based on the measured response data, and the observability of the system state space model is used to treat the Hankel matrix as three components containing system characteristics, excitation and noise. Singular value decomposition is used to factorize the data matrix and use the characteristics of the left and right singular matrices to reduce the dimension of the data matrix to improve calculation efficiency. Furthermore, the singular spectrum is employed to estimate the minimum order to reconstruct the Hankel matrix; then, the excitation and noise components can be removed, and the system observability matrix can be obtained. By appropriately a factorizing system observability matrix, we obtain the system matrix to estimate the modal parameters. In addition, the fictitious modes produced by increasing the order of the matrix can be eliminated through the stabilization diagram.
A Three-Stage Dynamic Assessment Framework for Industrial Control System Security Based on a Method of W-HMM
Authors: Ji Xudong , Wei Hongxing , Chen Youdong , Ji Xiao-Fang , Wu Guo
Published: March 2022

Industrial control systems (ICS) are applied in many fields. Due to the development of cloud computing, artificial intelligence, and big data analysis inducing more cyberattacks, ICS always suffers from the risks. If the risks occur during system operations, corporate capital is endangered. It is crucial to assess the security of ICS dynamically. This paper proposes a dynamic assessment framework for industrial control system security (DAF-ICSS) based on machine learning and takes an industrial robot system as an example. The framework conducts security assessment from qualitative and quantitative perspectives, combining three assessment phases: static identification, dynamic monitoring, and security assessment. During the evaluation, we propose a weighted Hidden Markov Model (W-HMM) to dynamically establish the system’s security model with the algorithm of Baum–Welch. To verify the effectiveness of DAF-ICSS, we have compared it with two assessment methods to assess industrial robot security. The comparison result shows that the proposed DAF-ICSS can provide a more accurate assessment. The assessment reflects the system’s security state in a timely and intuitive manner. In addition, it can be used to analyze the security impact caused by the unknown types of ICS attacks since it infers the security state based on the explicit state of the system.
A Reconfigurable Framework for Vehicle Localization in Urban Areas
Authors: Viana Kerman , Zubizarreta Asier , Diez Mikel
Published: March 2022

Accurate localization for autonomous vehicle operations is essential in dense urban areas. In order to ensure safety, positioning algorithms should implement fault detection and fallback strategies. While many strategies stop the vehicle once a failure is detected, in this work a new framework is proposed that includes an improved reconfiguration module to evaluate the failure scenario and offer alternative positioning strategies, allowing continued driving in degraded mode until a critical failure is detected. Furthermore, as many failures in sensors can be temporary, such as GPS signal interruption, the proposed approach allows the return to a non-fault state while resetting the alternative algorithms used in the temporary failure scenario. The proposed localization framework is validated in a series of experiments carried out in a simulation environment. Results demonstrate proper localization for the driving task even in the presence of sensor failure, only stopping the vehicle when a fully degraded state is achieved. Moreover, reconfiguration strategies have proven to consistently reset the accumulated drift of the alternative positioning algorithms, improving the overall performance and bounding the mean error.
Correction: Jegannathan et al. An Overview of CMOS Photodetectors Utilizing Current-Assistance for Swift and Efficient Photo-Carrier Detection. Sensors 2021, 21, 4576
Authors: Jegannathan Gobinath , Seliuchenko Volodymyr , Van den Dries Thomas , Lapauw Thomas , Boulanger Sven , Ingelberts Hans , Kuijk Maarten
Published: March 2022

There was an error in the original publication, in Equation (5) [...]
Continuous Hidden Markov Model Based Spectrum Sensing with Estimated SNR for Cognitive UAV Networks
Authors: Feng Yuqing , Xu Wenjun , Zhang Zhi , Wang Fengyu
Published: March 2022

In this paper, to enhance the spectrum utilization in cognitive unmanned aerial vehicle networks (CUAVNs), we propose a cooperative spectrum sensing scheme based on a continuous hidden Markov model (CHMM) with a novel signal-to-noise ratio (SNR) estimation method. First, to exploit the Markov property in the spectrum state, we model the spectrum states and the corresponding fusion values as a hidden Markov model. A spectrum prediction is obtained by combining the parameters of CHMM and a preliminary sensing result (obtained from a clustered heterogeneous two-stage-fusion scheme), and this prediction can further guide the sensing detection procedure. Then, we analyze the detection performance of the proposed scheme by deriving its closed-formed expressions. Furthermore, considering imperfect SNR estimation in practical applications, we design a novel SNR estimation scheme which is inspired by the reconstruction of the signal on graphs to enhance the proposed CHMM-based sensing scheme with practical SNR estimation. Simulation results demonstrate the proposed CHMM-based cooperative spectrum sensing scheme outperforms the ones without CHMM, and the CHMM-based sensing scheme with the proposed SNR estimator can outperform the existing algorithm considerably.
Research on Three-Dimensional Stress Monitoring Method of Surrounding Rock Based on FBG Sensing Technology
Authors: Liang Minfu , Fang Xinqiu , Song Yang , Li Shuang , Chen Ningning , Zhang Fan
Published: March 2022

Research on the stress state of rock mass is essential for revealing the distribution characteristics and evolution law of the surrounding rock stress field in the roadway, studying the coal–rock dynamic disaster and the design of roadway support. This thesis proposes a three-dimensional stress monitoring method for surrounding rocks based on fiber Bragg grating (FBG) sensing technology and a cube-shaped three-dimensional stress fiber grating sensor is developed based on the principle of this monitoring method. According to the fiber grating strain obtained by numerical simulation, the calculated three-dimensional stress value is basically consistent with the theoretical value. The margin of error was plus or minus one percentage point. The sensing performance of the sensor was tested using a uniaxial compression experiment instead of a triaxial compression experiment. The experimental results show that in the range of 0~50 Mpa, the sensor’s sensitivity to X, Y and Z axis stress is 25.51, 25.97 and 24.86 pm/Mpa, respectively. The relative error of measured stress is less than 4%. Meanwhile, the sensor has good linearity and repeatability, and has broad application prospects in the field of underground engineering safety monitoring such as in coal mines and tunnels.
KinectGaitNet: Kinect-Based Gait Recognition Using Deep Convolutional Neural Network
Authors: Bari A. S. M. Hossain , Gavrilova Marina L.
Published: March 2022

Over the past decade, gait recognition had gained a lot of attention in various research and industrial domains. These include remote surveillance, border control, medical rehabilitation, emotion detection from posture, fall detection, and sports training. The main advantages of identifying a person by their gait include unobtrusiveness, acceptance, and low costs. This paper proposes a convolutional neural network KinectGaitNet for Kinect-based gait recognition. The 3D coordinates of each of the body joints over the gait cycle are transformed to create a unique input representation. The proposed KinectGaitNet is trained directly using the 3D input representation without the necessity of the handcrafted features. The KinectGaitNet design allows avoiding gait cycle resampling, and the residual learning method ensures high accuracy without the degradation problem. The proposed deep learning architecture surpasses the recognition performance of all state-of-the-art methods for Kinect-based gait recognition by achieving 96.91% accuracy on UPCV and 99.33% accuracy on the KGB dataset. The method is the first, to the best of our knowledge, deep learning-based architecture that is based on a unique 3D input representation of joint coordinates. It achieves performance higher than previous traditional and deep learning methods, with fewer parameters and shorter inference time.
QoS-Aware Algorithm Based on Task Flow Scheduling in Cloud Computing Environment
Authors: Rakrouki Mohamed Ali , Alharbe Nawaf
Published: March 2022

This paper deals with the challenging problem of scheduling users’ tasks, while taking into consideration users’ quality of service (QoS) requirements, with the objective of reducing the energy consumption of physical machines. This paper presents a model to analyze the current state of the running tasks according to the results of the QoS prediction assigned by an ARIMA prediction model optimized with Kalman filter. Then, we calculate a scheduling policy with a combined particle swarm optimization (PSO) and gravitational search algorithm (GSA) algorithms according to the QoS status analysis. Experimental results show that the proposed HPSO algorithm reduces resources consumption 16.51% more than the original hybrid algorithm, and the violation of service-level agreement (SLA) is 0.053% less when the optimized prediction model is used.
Evaluation of the potential efficiency of an innovative product in the early phases
Authors: Boyko V. , Startsev V.
Published: March 2022

Outlines the main provisions and assumptions for measuring and evaluating the potential effectiveness of creating an innovative product; systematized methods for measuring and evaluating the effects of innovative intention by phases; objects of measurement, indicators and bases for comparing effects, as well as subjects of evaluation are considered; recommendations are given on the development of marketing tools in order to assess the economic feasibility of implementing innovation in the early phases.
Approaches — the main methodological tool of management science in economic systems such as “organization”
Authors: Gerasimov B.
Published: March 2022

Research of forms and contents of methodological tools allowed to define the significant role of main approaches in a management science. Systemic, process and functional approaches are used more often than others in forming and ensuring the implementation of various attributes in the technology and practice of management of various objects in social and economic environments. Scientific literature and empirical studies allowed you to substantiate the need for their combined use in the construction and reform of economic systems of the type “organization”. The use of these tools for the design and reformation of any attributes of management will improve the quality and efficiency of processes and their parts in organizations at all stages of their operation.
ONLINE TRAINING AS ONE OF THE EFFECTIVE FORMS OF BLENDED LEARNING OF FUTURE LAWYERS IN PROFESSIONAL PRELIMINARY EDUCATION INSTITUTIONS
Authors: SOKIL A.
Published: March 2022

The article outlines the directions of using trainings during mixed training of future lawyers in institutions of professional higher education. The stages of conducting online trainings for future lawyers in the institution of professional higher education are determined and characterized: preparatory-target, design-methodical, implementation-technological and analytical-reflective.
SENTIMENT ANALYSIS OF REKSADANA ON BIBIT APPLICATIONS USING THE NAÏVE BAYES METHOD AND K-NEAREST NEIGHBOR (KNN)
Authors: Fitriyani Alisa , Triayudi Agung
Published: March 2022

The public's lack of interest in the capital market has made the top brass of capital market companies compete with each other to provide services in order to provide convenience for customers in the various services available and provide convenience in accessing financial information. The emergence of several startup companies that provide mutual fund investment products for investors, namely PT Bibit Reksadana Grow Together, which created a mutual fund application, namely Bibit Mutual Fund with more than one million users based on data downloaded on the play store by PT Bibit Grow Bersama which acts as a Mutual Fund Selling Agent (APERD) and sells 134 mutual fund products. So, to provide information to the public, it is necessary to have a sentiment analysis on how the opinions of users of the mutual fund seed application use the methodK-nearest neighbor (KNN) and Naïve Bayes, with the results of crawling data of 3800 tweets and scraping of 5000 reviews, then the text processing and labeling stages are carried out using the textblob library, with a high level of accuracy in the classification of tweet data and review data using the K-nearest neighbor method. Nearest Neighbor as much as 88%, 100%, and Naïve Bayes as much as 100%, 100%, it can be concluded that positive opinions from seed mutual fund users are more than negative sentiments.
Clinical Observation of a Rare Phenotype of Brugada Syndrome
Authors: Комиссарова С.М. , Барсукевич В.Ч. , Ринейская Н.М. , Чакова Н.Н. , Ниязова С.С. , Долматович Т.В. , Засим Е.В.
Published: March 2022

Синдром Бругада – это наследственное нарушение сердечного ритма, характеризующееся подъемом сегмента ST в правых прекордиальных отведениях, блокадой правой ножки пучка Гиса, инверсией зубца Т при отсутствии явных структурных заболеваний сердца. Данное заболевание служит причиной внезапной сердечной смерти в 2% случаев ежегодно. Синдром Бругада является генетически гетерогенной каналопатией и связан с мутациями в генах, кодирующих субъединицы натриевых, калиевых и кальциевых каналов сердца и связанных с ними белков. Авторы представили клинический случай 34-летней пациентки с синдромом Бругада, у которой обнаружена комбинация мутаций в генах KCNJ8, HCN4, CASQ2. Диагноз был подтвержден пробой с новокаинамидом и эндокардиальным ЭФИ, когда при программируемой стимуляции желудочков спровоцирован устойчивый пароксизм полиморфной ЖТ и характерный паттерн Бругада с подъемом сегмента ST. Особенностью данного клинического случая было наличие у пациентки АВ-реципрокной тахикардии, выявленной при эндокардиальном ЭФИ. В связи с этим ей была выполнена абляция медленных путей АВ-узла с целью минимизации возможных необоснованных срабатываний ИКД на АВ-реципрокную тахикардию. Ввиду высокого риска рецидивирования жизнеугрожающих аритмических событий было принято решение об имплантации пациентке КД.

Brugada syndrome is an inherited heart rhythm disorder characterized by ST-segment elevation in the right precordial leads, right bundle branch block, T wave inversion in the absence of obvious structural heart diseases. This disease causes sudden cardiac death in 2% of cases annually. Brugada syndrome is a genetically heterogeneous channelopathy, and it is associated with mutations in genes encoding subunits of the heart’s sodium, potassium, and calcium channels, and related proteins. The authors presented a clinical case of a 34-year-old patient with Brugada syndrome, who had a combination of mutations in the KCNJ8, HCN4, and CASQ2 genes. The diagnosis was confirmed by provocative drug test with novocainamide and endocardial EF study, when a steady paroxysm ofpolymorphic VT and a typical Brugada pattern with ST-segment elevation were provoked during programmed ventricular stimulation. The peculiarity of this clinical case was the presence of AV- reciprocal tachycardia in the patient, detected during endocardial EF study. In this regard, she underwent ablation of the slow pathways of the AV node in order to minimize possible unjustified ICD responses to AV reciprocal tachycardia. Due to the high risk of recurrence of life-threatening arrhythmic events, it was decided to implant a cardioverter-defibrillator.
Development of General and Private Algorithms for Pharmaceutical Consultation of a Patient in a Pharmacy
Authors: Янушевская А.В. , Годовальников Г.В. , Кулай Н.С.
Published: March 2022

В связи с изменением функций провизора-рецептара розничной аптеки, связанных с необходимостью проведения фармацевтического консультирования пациентов по лекарственным средствам (ЛС), реализуемым без рецепта врача, по постановке диагноза (контроля верности самодиагноза пациента) и подбора ЛС, необходимым становится стандартизация этой процедуры с целью повышения эффективности консультирования. Исходя из этого, были разработаны алгоритмы общего консультирования и частного (при венозной недостаточности), которые позволят провизору соблюдать современные требования к консультированию и минимизируют вероятность ошибки при оценке симптомов пациента и рекомендации ему ЛС. С целью оценки профессионального уровня фармацевтического консультирования в розничных аптеках Минска было проведено интервьюирование провизоров-рецептаров и фармацевтов-рецептаров методом тайного покупателя . Проведенные исследования позволили сделать вывод об уровне консультирования в аптеках и необходимости дальнейших научных разработок в этой области.

Due to the changes in the functions of the pharmacist of a retail pharmacy, related to the need for pharmaceutical counseling for patients about medicines (drugs) sold without a prescription, about diagnosis (control of the accuracy of the patients self-diagnosis) and selection of drugs, which requires standardization of this procedure in order to increase the effectiveness of counseling. Based on this, algorithms have been developed for General and private counseling (for venous insufficiency), which will allow the pharmacist to comply with modern requirements for counseling and minimize the likelihood of error in assessing the patients symptoms and recommending drugs to him. In order to assess the professional level of pharmaceutical consulting in retail pharmacies in Minsk, interviewing pharmacists-prescribers and interviewing pharmacists-prescribers by using the secret buyer method were conducted. The research made it possible to draw a conclusion about the level of consulting in pharmacies and the necessity for further scientific developments in this area.
Keputusan Konsumen Mengkonsumsi Pinang Kering Iris di Kecamatan Kota Kefamenanu Kabupaten Timor Tengah Utara
Authors: Nubatonis Agustinus , Alupan Elisabeth Ananda Putri , Maulana Achmad Subchiandi , Joka Umbu , Sipayung Boanerges Putra
Published: March 2022

Consumption of areca nut has become a culture of society in the District of Kota Kefamenanu. Sliced dried areca nut is an option for consumption because it can last a long time. Slice dried arecal nut in Kota Kefamenanu sub-district is divided into two types, namely dry iris batu nut and iris dry muda nut. This study aims to analyze the consumer's decision to consume sliced dried areca batu and slice dry areca muda nut in Kota Kefamenanu District. This research was conducted from September to October 2021. The number of samples used in this study was 150. Consumer decisions in Kefamenanu City were analyzed by logistic regression using software Eviews9. The results showed that psychological factors and texture variables had a significant effect on consumer decisions to consume sliced dried areca nut in Kefamenanu City District.
Editorial
Authors: Rocchietti Ana , Pasquali Cristina
Published: March 2022

Se alude a los objetivos teóricos y prácticos de la disciplina y al cierre de la publicación del IX Simposio sobre la Arqueología Histórica Latinoamericana.
PERTENTANGAN UNDANG-UNDANG INFORMASI DAN TRANSAKSI ELEKTRONIK DENGAN UNDANG-UNDANG TRANSFER DANA DALAM PERDAGANGAN BERJANGKA KOMODITI BERBASIS INTERNET
Authors: Pitaloka Endang Dyah Ayu
Published: March 2022

Penelitian ini dilatarbelakangi oleh adanya permasalahan internal hukum yang saling bertentangan dalam perdagangan berjangka komoditi. Tujuan penelitian ini adalah untuk mengetahui pertentangan antara Pasal 27 ayat (2) Undang-Undang Informasi dan Transaksi Elektronik dengan Pasal 15 ayat (1) Undang-Undang Transfer Dana dan juga untuk mengetahui upaya perlindungan hukum bagi nasabah yang bertransaksi dalam perdagangan berjangka komoditi berbasis internet. Penelitian hukum ini merupakan penelitian hukum normatif yang berfokus pada perspektif internal dengan objek penelitiannya adalah norma hukum. Hasil penelitian menyimpulkan dua hal, pertama, terjadinya pertentangan antara Pasal 27 ayat (2) Undang-Undang Informasi dan Transaksi Elektronik dengan Pasal 15 ayat (1) Undang-Undang Transfer Dana dalam Perdagangan Berjangka Komoditi Berbasis Internet karena adanya dua ketentuan yang saling bertolak belakang yakni Pemblokiran dan Pengaksepan. Kedua, meskipun terdapat kontrak sebagai instrumen yang dapat mengikat para pihak pembuatnya, namun perlindungan hukum bagi nasabah Indonesia yang bertransaksi dalam perdagangan berjangka komoditi berbasis internet yang menggunakan jasa pialang luar negeri dinilai masih lemah sehingga nasabah Indonesia berada pada posisi rentan terhadap pialang luar negeri.
STUDI KRITIS EKSAMINASI PUBLIK DALAM MENGAWASI PUTUSAN HAKIM PERKARA KORUPSI
Authors: Hapsoro Fakhris Lutfianto , Harijanti Susi Dwi , Abdurahman Ali
Published: March 2022

Eksaminasi publik terhadap putusan perkara korupsi kerap dilakukan oleh lembaga swadaya masyarakat dan lembaga kajian di Fakultas Hukum. Ada tiga lembaga yang menyelenggarakan eksaminasi publik terhadap putusan praperadilan BG, dimana rekomendasi hasil eksaminasi publik dari ketiga lembaga tersebut diabaikan oleh Mahkamah Agung. Penelitian ini dibatasi dengan dua identifikasi masalah: bagaimana pelaksanaan eksaminasi publik terhadap putusan praperadilan BG yang dilakukan oleh ICW, LKBH FH Unand, dan MaPPI FH UI; dan bagaimana upaya penguatan eksistensi eksaminasi publik agar dapat diperhatikan oleh Mahkamah Agung. Kedua identifikasi masalah tersebut dijawab menggunakan metode pendekatan sosio-legal, menggunakan spesifikasi penelitian evaluatif dan deskriptif analitis, serta menggunakan data sekunder (studi kepustakaan) yang didukung oleh data primer (wawancara). Hasil penelitian ini menunjukkan dua hal, yaitu pertama, pelaksanaan eksaminasi publik yang dilakukan oleh ketiga lembaga tersebut menghasilkan hasil yang sama, yaitu menilai hakim praperadilan telah keliru dalam melakukan penemuan/penerobosan hukum untuk memperluas ruang lingkup upaya paksa. Namun, komposisi majelis eksaminator pada MaPPI FH UI bersifat internalistik dan teknokratis; Kedua, upaya penguatan eksistensi eksaminasi publik dapat dimuat klausul akomodasi hasil eksaminasi publik di dalam Peraturan Mahkamah Agung.
A Review: p-Coumaric Acid, A Medicinally Important Phenolic Acid Moiety
Authors: Sharma Shashi , Khatkar Anurag , Kakkar Saloni
Published: March 2022

p-Coumaric acid is an ubiquitous natural phenolic phytochemical mainly exist in two forms trans- and cis-p-coumaric acid. It occurs in free as well as in bound forms, is a common dietary polyphenol distributed in fruits, vegetables and cereals. It was considered as a powerful antioxidant and widely reported to demonstrate antimicrobial, antifungal, anticancer, antidiabetic, anti-inflammatory, antiviral, antihypertensive, antiulcer, antiprotozoal and antimelanogenic. This review contains the fundamental information about biological potential, common pathway utilized, SAR, wide source of p-coumaric acid and evidence of their role in disease prevention. © 2020 iGlobal Research and Publishing Foundation. All rights reserved.
The Role of Talent Management in the Management of Contemporary Hotels
Authors: Knap-Stefaniuk Agnieszka , Karna Wioleta J.
Published: March 2022

In the dynamic environment of the tourism industry, especially in hotel management, a properly implemented concept of talent management has a significant impact on attracting, hiring, developing, and maintaining outstanding, talented employees in order to develop long-term. The main goal of the article is to determine the role of talent management in the management of contemporary hotels. Based on numerous sources, the authors argue that the approach to talent management in hotels leads to more effective use of human resources and builds a competitive advantage. In the first part of the article, the authors explain the concepts of talent and talent management and highlight the importance of talent management in human resources management. The next part describes the special role of managers in the process of talent management in hotels. Next, the authors present the employment in the hotel industry in EU countries; in the last part of the article they indicate mistakes and challenges related to the talent management in the hotel industry.

Challenges in the field of talent management basically apply the entire process, managing the whole talent flow (entry, learning, development, compensation, analysis and evaluation, and exit). One of the biggest challenges in the field of talent management are attracting talented employees and positioning the organization (hotel) as a desirable employer and systematic building and updating the organization’s talent map, with an indication of the strengths and weaknesses of talented employees as well as the possibilities and limitations of their development.
Intense emission of surface-derived secondary ions from shallow-angle impacts of energetic MeV C60 ions
Authors: Hirata Kouichi , Yamada Keisuke , Chiba Atsuya , Hirano Yoshimi , Saitoh Yuichi
Published: March 2022

Impacts of energetic C60 ions with energies of the order of MeV are excellent ionization methods for highly sensitive secondary ion (SI) mass spectrometry because they can provide SIs necessary for the identification of target materials in high emission yields with high reproducibility. As part of an investigation into their SI emission phenomena with the aim of controlling the mass-analyzed depth range, we measured and characterized the impact angle dependence of SI mass spectra for MeV C60 ion impacts, and found that shallower angle impacts of MeV C60 ions can provide surface-sensitive information through intense emission of surface-derived SIs.
Faktor yang Berhubungan dengan Penerapan 6 Sasaran Keselamatan Pasien
Authors: Putri Miko Eka , Fithriyani Fithriyani , Sari Mila Triana
Published: March 2022

Patient safety is a system that must be implemented in hospitals. This is done by the government in an effort to prevent patient safety incidents from occurring. Based on the Lumenta report (2008) that in Indonesia from 145 reported incidents of near-injury (KNC) as many as 47.6% cases, unwanted events (KTD) as many as 46.2% cases, and others as many as 6.2% cases. . The KTD rate at Raden Mattaher Hospital in 2016 was 10 cases, increasing to 13 cases in 2017 and decreasing to 7 cases in 2018. Many factors affect the implementation of patient safety, namely internal and external factors. The purpose of this study was to determine the factors associated with the implementation of 6 patient safety goals at Raden Mattaher Hospital Jambi. The design of this study used a cross-sectional study. The number of samples in this study were 80 nurses with proportional random sampling technique. The analysis used was univariate and bivariate analysis with Chi-square and Wilcoxon tests. The results of the analysis show that the average age is 33.19 years and the length of work is 9.39 years. A total of 71.2% are female, 82.5% have vocational education, 68.8% have sufficient knowledge, 56.2% are positive and 65% of respondents do not apply the 6 patient safety goals. The results of the bivariate analysis showed that there was a relationship between age, length of work and attitude with the implementation of the 6 patient safety goals.
The "Scourge" of Armed Check Fraud: A Constitutional Framework for Prohibited Possessor Laws
Authors: Giancana Jeffrey
Published: March 2022

Prohibited possessor statutes have been a part of American law for decades. Put simply, these laws prohibit any person who has been convicted of a felony from possessing a firearm, a prohibition that lasts for the felon’s entire life. The Supreme Court’s modern Second Amendment jurisprudence has held that the right to possess a firearm is a fundamental individual right. In light of this new paradigm, the constitutionality of such broad prohibitions must be called into question—despite the eagerness of courts across the country to dismiss such challenges by pointing to a single line in Heller. This Note challenges the constitutionality of modern prohibited possessor laws and asserts that these laws are unconstitutionally overbroad. It then proposes a constitutional framework for analyzing laws that ban firearm possession by felons.
Establishing a More Effective SAFMR System: The Cost and Benefits of HUD's 2016 Small Area Fair Market Rent Rule
Authors: Treat John
Published: March 2022

This Note analyzes the new HUD rule finalized in November 2016, which dramatically changed the structure of the Housing Choice Voucher program in select metropolitan areas. In August 2017, HUD suspended automatic implementation of the rule until 2020 for twenty-three of the twenty-four selected metropolitan areas, but in December 2017, a preliminary injunction was granted requiring HUD to implement the rule as of January 1, 2018. The rule as written changes the method for calculating the vouchers from using a metropolitan area-wide average to calculating a separate level for each zip code. Such a change could greatly deconcentrate poverty and reduce economic and racial segregation; a result that the current status quo has failed to accomplish. The new rule, however, is not without its flaws. This Note offers a number of recommendations for changing the rule to address these flaws: (1) tweaking metro area selection criteria to include large, highly-segregated areas; (2) granting public housing agencies flexibility in implementing the rule; (3) including new protections for gentrifying neighborhoods and additional funding for landlord outreach and mobility counseling; and (4) revising methodology to increase accuracy. Despite the problems with the new rule, as long as HUD is truly committed to implementing it, its benefits are likely to outweigh its flaws.
Una reflexión teórica sobre la documentación del arte contemporáneo: una propuesta para un protocolo cronológico
Authors: Llamas-Pacheco Rosario
Published: March 2022

Contemporary artwork is a complex entity made up of several superimposed planes: the material plane, the conceptual plane and the biographical plane. The need to apprehend the entity, determining where its substantial attributes lie, those that determine its consistency and constitute both, its essence and its specificity, is the objective of the documentation. This article proposes a documentation protocol that collects, from an empirical and useful perspective, the order in which the different actions of the contemporary art conservator should be documented. This protocol must analyse the different planes of which the artworks consist; it must apply an updated decision-making model and prioritise the relative importance of the material and immaterial constituents of the artworks. It must also include the documentation of the intervention process itself. The order and the tools to achieve it are analyzed in this article.
Taxonomic study of Collybiopsis (Omphalotaceae, Agaricales) in the Republic of Korea with seven new species
Authors: Kim Ji Seon , Cho Yoonhee , Park Ki Hyeong , Park Ji Hyun , Kim Minkyeong , Kim Chang Sun , Lim Young Woon
Published: March 2022

Collybiopsis is a genus of the gymnopoid/marasmioid complex of the family Omphalotaceae. The classification system of Collybiopsis has recently undergone large changes through molecular approaches. The new classification system has not been applied for Collybiopsis in the Republic of Korea, and general research on this genus was also lacking. In this study, we analyzed the Collybiopsis species in the Republic of Korea by assessing all gymnopoid/marasmioid specimens collected nationwide for ten years by combining morphological approaches and multilocus (ITS + nrLSU) phylogenetic analysis. We thus confirmed that 16 species of Collybiopsis are present in the Republic of Korea, including two previously unreported species (Co. nonnulla and Co. dichroa) and seven new species (Co. albicantipessp. nov., Co. clavicystidiatasp. nov., Co. fulvasp. nov., Co. orientisubnudasp. nov., Co. subumbilicatasp. nov., Co. undulatasp. nov., and Co. vellereasp. nov.). A thorough examination of the Collybiopsis suggested that it is difficult to distinguish or identify the species based on morphological characteristics only; a combined molecular approach is needed for accurate identification. The Collybiopsis database of the Republic of Korea is updated, and information on the new species is provided. Five new combinations from Marasmiellus to Collybiopsis are also proposed (Co. istanbulensiscomb. nov., Co. koreanacomb. nov., Co. omphalodescomb. nov., Co. pseudomphalodescomb. nov., and Co. ramuliciolacomb. nov.).
PSICANÁLISE E POLÍTICA: A HOSTILIDADE CONTEMPORÂNEA FRENTE AO NOVO
Authors: Barboza Edcarla Melissa de Oliveira , Andrade Cleyton Sidney
Published: March 2022

O presente artigo é resultado de uma pesquisa teórica em psicanálise ainda em andamento, que se dedica a investigar possíveis dispositivos no interior da racionalidade contemporânea que operam de forma hostil a processos passíveis de inscrever uma novidade radical. A história mostra que algumas insurreições e formas de resistência popular, que pareciam demonstrar a potência de produzir uma novidade, resultaram, no entanto, num retrocesso ou numa outra forma de alienação, com semblante de novidade, explicitando a presença de um impasse em torno da concepção do novo. Diante disso, esta pesquisa lança mão do conceito lacaniano de ato analítico e da noção de acontecimento em Alain Badiou, a fim de identificar indicadores passíveis de instituir uma novidade com potência política de transformação radical. Tanto a clínica quanto a política evidenciam que a produção de uma novidade exige uma ruptura abrupta e contingente, fora de qualquer ordem estabelecida pelo saber. O novo advém em desarticulação com o campo dos saberes existentes, compreendendo, pois, uma invenção singular, que não encontra lugar no horizonte previsível e calculável, do qual se nutre a razão neoliberal.
REDES SOCIAIS SIGNIFICATIVAS DE GESTANTES DE ALTO RISCO: UM ESTUDO QUALITATIVO
Authors: Maffei Bruna , Menezes Marina , Krenkel Scheila , Crepaldi Maria Aparecida
Published: March 2022

As redes sociais significativas constituem importantes recursos de enfrentamento diante de períodos de transição, em que são exigidas adaptações frente a situações difíceis, como no caso de uma gestação de alto risco. Este estudo objetivou compreender a dinâmica relacional das redes sociais significativas de gestantes de alto risco. Trata-se de uma pesquisa qualitativa, da qual participaram 13 mulheres que estavam sendo acompanhadas em um ambulatório de pré-natal de alto risco, localizado na região Sul do Brasil. A coleta dos dados ocorreu por meio de um roteiro de entrevista semiestruturada e da construção de mapas de rede. Os dados foram submetidos à análise de conteúdo proposta por Bardin e organizados com auxílio do software Atlas.ti 7.0. Os resultados mostraram que houve predomínio de redes grandes, com maior concentração de membros da família, em especial do companheiro e da mãe. Destaca-se o apoio emocional como principal função desempenhada pelos integrantes da rede, a centralidade do médico nos cuidados de alto risco e a importância do apoio prestado às gestantes, na prática de hábitos saudáveis e no autocuidado.