bluuebunny/crossref_metadata_2025 huggingface dataset:
The Informational-Educational Environment of Additional Professional Education for Learning the Basics of Green Construction
Authors:   Ural Federal University, Quanpeng Li Quanpeng Li , Mironova Lyudmila I. ,   Ural Federal University
Published: October 2024

The relevance of the topic of the article is determined by the need to introduce promising green building technology into domestic construction practice. The purpose of the article is based on the analysis of the current situation with green construction in Russia to substantiate the need for students of the system of additional professional education to master the basics of green construction technology and to develop an educational retraining program and appropriate educational and methodological support related to the study of the basics of green construction. The following research methods are used: theoretical analysis of scientific results devoted to the identification of the essence of development and the establishment of trends in various systems of civil engineering education, analysis of curricula and manuals for architectural and construction training of students; expert analytical methods for evaluating the content of methodological and software tools designed to master special disciplines in architectural and construction training of students in the context of digital transformation of education. As a result of the analysis of scientific publications in the field of educational management, the need to improve the system in the field of architectural and construction training and the development of green building technology has been identified. The analysis of the existing shortcomings of traditional construction project management is carried out, the need to study the basics of green construction and develop appropriate educational and methodological materials implemented in the context of digital transformation of the construction industry is justified. The content structure for the development of an electronic educational resource for the study of the discipline is considered, the content of each block of content is described, and the connections between the blocks are shown. The reasons hindering the development of engineering management of green construction in Russia are systematized. Advanced training of students in the field of green construction will help to overcome the factors hindering the introduction of green technology in domestic construction. The results of the article may be of interest to specialists of architectural and construction universities engaged in the preparation of bachelors and masters for the construction industry in the context of digital transformation of education. Keywords: “green” construction, advanced training, construction education, system of additional professional education, electronic educational resource
Computer Modeling as a Method of Educational Cognition and its Application in the Study of Subjects of the Natural Science Cycle in Secondary School
Authors:   Perm State National Research University, Ospennikova Elena V. , Аntonova Darya A. ,   Perm State National Research University
Published: October 2024

The article discusses the problem of forming secondary school students’ perceptions of the modern system of scientific cognition methods. The relevance of this problem is determined by the need to include the computer modeling method in this system as an object of study. This method, mastered by schoolchildren in the informatics course (basic and specialized), is hardly applied in teaching natural science subjects. At the same time, the readiness of school graduates to apply modern methods of cognition in solving cognitive tasks, including the use of information technology tools, is defined by the Educational Standard as one of the most important meta-objective learning outcomes. It is established that the level of meta-objective generalization of experience in computer modeling can only be achieved by including this method in the practice of teaching a complex of educational subjects, and primarily, natural sciences. The importance of mastering the system of generalized methodological guidelines for the organization schoolchildren’ educational work on the development of this method by a subject teacher is substantiated. The basic guideline of this system is defined: the structure of computer modeling in its version adapted for secondary school. The article provides an overview of the approaches of researchers to the development of such a structure. The differences between these approaches are revealed. The novelty of the research lies in the adjustment of the stages of computer modeling as a method of cognition and the detailing of their content. The functions of the method (constructive, instrumental) are indicated, which should become the subject of study and development for schoolchildren. The practical significance of the results obtained is associated with the creation of a functionally more complete indicative basis for the practice of using computer modeling in teaching. For school students, this is important for a deeper understanding of the essence of the method and the features of its use in solving research tasks. For a teacher, this is the basis for purposeful planning and organization of teaching computer modeling to schoolchildren within the framework of a basic training course in the subject, including the construction and implementation of a system of its interdisciplinary links with courses in informatics and mathematics. Keywords: methods of cognition in natural science education, computer modeling, computer experiment, computer models in subject education in secondary school, methods of teaching physics
Trauma Narratives: Collective Memories as Literature by Indochinese Refugees in the United States
Authors: Kittiphong Praphan
Published: October 2024

Indochinese refugees in the United States are part of Asian Americans, whose narratives portray their life in their home countries, journeys to the new world and life in the United States, their new world. This study investigates three primary texts by American authors of Indochinese descent, including Lan Cao’s Monkey Bridge, Sichan Siv’s Golden Bones and Sucheng Chan’s Hmong Means Free. These three texts are highly historicised, portraying traumatic experiences of Indochinese refugees who suffer from war and communist persecution in Vietnam, Cambodia and Laos, respectively. These texts are considered trauma narratives serving as collective memories of those people, which help them to remember their pasts and constitute their group identity. The narratives in the three primary texts also explain how Indochinese subjects come to be Asian Americans and reveal that in fact the United States is considered an important cause of their diaspora and trauma. The authors of those narratives are unable to eradicate the traumatic memories from their psyche, so they yearn for voices to vent out those memories as a form of healing. Their trauma narratives have become part of American culture which is partially constituted by trauma suffered by different groups of people in this country.
Kata Kerja Ambitransitif dalam Bahasa Melayu: Suatu Analisis Minimalis
Authors: Ahmad Syafiq Amir Abdullah Zawawi  , Fazal Mohamed Mohamed Sultan  , Azhar Jaludin
Published: October 2024

This study aims to explore the transitivity of Malay verbs, which has been understudied in previous research that only focused on four categories: transitive, bitransitive, unaccusative and uncausative. The previous studies claimed that each verb can only support one transitivity feature. However, this study aims to fill the gap by providing a syntactic explanation of verbs that have more than one transitivity feature in Malay, namely ambitransitive verb. The study focuses on one lexical item “ada”, which functions as a verb. The data was collected from the Dewan Bahasa dan Pustaka corpus and analysed in two types of sentences, possession sentences in FN-ada-FN structure and existential sentences in FN-ada structure. The results showed that “ada” has a monotransitive characteristic in possession sentences FN-ada-FN, but it has an unaccusative characteristic in existential sentences in FN-ada. This study contributes to the understanding of lexical items with multiple transitivity properties and provides evidence that ambitransitive verbs do exist and are used logically in Malay.
Kajian lepas berkaitan transitiviti kata kerja bahasa Melayu hanya tertumpu kepada empat kategori sahaja, iaitu transitif, dwitransitif, tak akusatif dan tak kausatif. Kajian lepas juga mendakwa setiap kata kerja (KK) hanya boleh mendukung satu ciri transitiviti sahaja. Namun, tiada penjelasan tuntas berkaitan leksikal yang dianggap ambitransitif, iaitu leksikal yang boleh mendukung lebih daripada satu sifat transitiviti. Maka, kajian ini bertujuan mengemukakan penjelasan sintaksis terhadap KK yang memiliki lebih daripada satu ciri transitiviti dari perspektif minimalis. Kajian ini mengehadkan satu leksis sahaja untuk dianalisis, iaitu “ada” yang berfungsi sebagai KK. Data kajian ini pula diperoleh daripada janaan korpus Dewan Bahasa dan Pustaka. Kajian ini menganalisis “ada” yang hadir dalam dua jenis ayat, iaitu ayat milik dalam struktur frasa nama (FN)-ada-FN dan ayat kewujudan dalam struktur FN-ada. Kajian ini mendapati dalam struktur milik FN-ada- FN, “ada” berciri KK monotransitif kerana mensubkategorisasikan satu argumen dalaman, iaitu FN sebagai komplemennya. Namun begitu, hal berbeza diperlihatkan dalam struktur kewujudan FN-ada apabila “ada” memiliki ciri sebagai KK tak akusatif. Kajian ini memberi impak terhadap penemuan leksis yang memiliki lebih daripada satu sifat transitiviti dan membuktikan bahawa KK ambitransitif sememangnya wujud dan digunakan secara nalar dalam bahasa Melayu.
Impact of auditor characteristics on audit quality during COVID-19: Evidence from Saudi Arabia
Authors: Shalhoob Hebah
Published: October 2024

This study aimed to analyze the impact of auditor characteristics on audit quality in Saudi Arabia during the COVID-19 pandemic by assessing how auditor characteristics (such as gender, age, education level, professional certificate, sector, size of the employees, revenue, experience, and region) impact audit quality in crisis conditions. It employed a descriptive-analytical approach and quantitative regression analysis of cross-sectional data. The survey was conducted in 2021 among 203 auditors in Saudi Arabia. Data collection was facilitated through the assistance of the Saudi Organization for Chartered and Professional Accountants (SOCPA) to make the sample more structured and representative. The results reveal that auditor characteristics played a significant role in determining audit quality during the pandemic. Gender, education level, audit firm size, and professionalism experience showed a strong correlation (r = 0.619) between professional experience and adaptability to remote auditing conditions. The regression analysis indicates a positive impact on audit performance. The results suggest practical implications for improving auditor selection, training programs, and regulatory frameworks to enhance audit resilience in times of crisis. It offers theoretical contribution by validating existing models under pandemic conditions and providing insights for the future of auditing practices. It also assists in establishing confidence in financial reporting together with control, making investors feel secure, and maintaining stability in the business world.
Pengaruh Penerapan Buku Cerita Digital dalam Meningkatkan Kemampuan Berbahasa Anak Usia Dini
Authors: Ningrum Yuli Widiya , Ashari Royana , Nisa’ Luthfatun
Published: October 2024

Penelitian ini didasarkan atas sebuah permasalahan keterampilan berbahasa anak usia dini. Penelitian ini menyoroti penggunaan buku cerita digital sebagai metode pembelajaran untuk meningkatkan keterampilan berbahasa anak usia dini. Penelitian ini bertujuan untuk mengevaluasi efektivitas buku cerita digital dalam meningkatkan keterampilan berbahasa anak usia dini, termasuk pemahaman kosakata, kemampuan berbicara, dan keterampilan mendengarkan. Selain itu, penelitian ini juga bertujuan untuk mengeksplorasi sejauh mana teknologi digital dapat memfasilitasi proses pembelajaran dan meningkatkan minat serta keterlibatan anak-anak dalam belajar berbahasa. Penelitian ini dilakukan di TK Nahdlatus Subban dengan mengamati respons anak-anak terhadap sesi dongeng yang dipimpin oleh peneliti. Metode penelitian menggunakan menggunakan teknik analisis data berupa uji wilcoxon match pairs test. Sampel berjumlah 15 anak dengan rentang usia 4-5 tahun di TK Nahdlatus Subban. Hasil penelitian menunjukkan kemampuan berbahasa anak berkembang secara signifikan berdasarkan hasil uji wilcoxon Thitung Ttabel (0 1,75). Berdasarkan pada perhitungan tersebut, maka dapat disimpulkan bahwa H1 diterima sedangkan H0 ditolak. Sehingga, buku cerita digital mempunyai pengaruh dalam kemampuan bahasa anak usia 4-5 tahun di TK Nadhlatus Subban.
Membangun Profesionalisme Guru PAUD Melalui Model Supervisi Klinis
Authors: Hasanah Iis Uswatun , Fauziah Nurul
Published: October 2024

Guru sebagai unsur tenaga pendidik mempunyai peran dalam keberhasilan proses pembelajaran yang berkualitas. Guru harus memiliki kompetensi dalam menjalankan profesinya sebagai guru professional, begitupula untuk guru PAUD  dituntut untuk memiliki kompetensi pedagogik, kompetensi kepribadian, kompetensi professional dan kompetensi social. Supervisi klinis merupakan pendekatan yang efektif dalam meningkatkan profesionalisme guru, kegiatan supervisi klinis ini sebagai upaya pembinaan untuk membantu guru PAUD dalam mengembangkan kompetensinya. Penelitian ini bertujuan untuk mengkaji penerapan model supervisi klinis dalam konteks Pendidikan Anak Usia Dini (PAUD) dan dampaknya terhadap peningkatan kompetensi guru. Melalui metode kualitatif yang meliputi observasi dan wawancara yang dilakukan di salah satu Lembaga PAUD yaitu KB Az-Zahra Kecamatan Wanayasa-Purwakarta, penelitian ini menyimpulkan bahwa supervisi klinis dapat menjadi alat yang ampuh untuk membantu guru PAUD dalam mengembangkan keterampilan pedagogik, refleksi diri, dan kemampuan dalam menciptakan lingkungan belajar yang efektif
Modeling the rainfall–runoff process in the Bird Creek River Basin: a comparative analysis of conceptual and artificial neural network techniques
Authors: Vidyarthi Vikas Kumar
Published: October 2024

The modeling of the rainfall–runoff (RR) process is a key component for water resources projects, planning, and management for which conceptual and data-driven modeling techniques are utilized. However, these techniques in the modeling of the RR process have their own benefits, and their performance need to be explored in real basins. In this paper, five conceptual models (namely, AWBM, Sacramento, SimHyd, SMAR, and TANK) and an artificial neural network (ANN) model have been developed and their performances have been assessed using the rainfall, runoff, and other climatic data derived from the Bird Creek Basin, USA. The results obtained from the study suggest that the SimHyd performed the best among all the conceptual models during testing. The ANN model performance in simulating the RR process was found to be the best among all the models developed in this study during testing with the highest values of R = 0.941, E = 0.994 and all threshold statistics and least values of AARE = 38.9 and NRMSE = 0.031. Overall, it can be concluded that although the conceptual models are highly comprehensible, the ANN models are able to simulate the flow more accurately than any of the conceptual models developed in this study.
Evaluation of satellite-derived precipitation datasets: a case study in the Ten Tributaries region of the Yellow River Basin
Authors: Liu Shuya , Ren Liliang , Zhao Chongxu , He Aoyu
Published: October 2024

Satellite-derived precipitation datasets are essential components of hydrological simulations, particularly in data-scarce regions of western China. However, a comprehensive assessment of their accuracy and reliability is required. Here, the accuracy of two high-resolution satellite-derived precipitation datasets, Integrated Multi-satellite Retrievals for GPM – Final (IMERG-F) and Gauge-Adjusted Global Satellite Mapping of Precipitation (GSMaP-Gauge), was evaluated across the Ten Tributaries region of the Yellow River Basin in western China using four quantitative metrics and three categorical scoring indicators. This evaluation sought to ascertain the retrieval accuracy of these products on both the daily scale and hourly scale of heavy precipitation events, and investigated their inversion error characteristics across various spatiotemporal scales. Both datasets effectively captured the spatiotemporal patterns of annual average precipitation within the study area. Notably, the daily-scale accuracy of these satellite-derived precipitation products surpassed their hourly and half-hourly counterparts. Both GPM-IMERG and GSMaP-Gauge adeptly reproduced most precipitation events in the Ten Tributaries region, with peak detection performance observed in the central and southern zones, providing a reliable data source for drought monitoring and hydrological modeling. Overall, compared with GPM-IMERG, GSMaP-Gauge displayed superior inversion accuracy across diverse spatiotemporal scales.
Locked out of water: a reflection on WaSH access in US prisons
Authors: Crosson Jesse , Sylvester Ruth E. , Worsham Kimberly
Published: October 2024

The United Nations global minimum standards for prisons are termed the ‘Nelson Mandela Rules’ and are based on the humane treatment of incarcerated people. Of the approximately 11.5 million people incarcerated worldwide, over two million are located in the United States (US). Mass incarceration is maintained by political, economic, and societal structures of inequality and discrimination. The lens of safely managed sanitation provides a window into the treatment and lived realities of people who are incarcerated. This article synthesizes the existing literature and builds on this foundational knowledge with accounts from people who have experienced living in the US prison system. Throughout the literature and across these lived accounts we find a severe lack of privacy, emotional distress, consistent Human Rights violations, and evidence of those in positions of power in prisons using control over water and sanitation to enact excessive punishment. Denying these fundamental rights restricts people's health and well-being, and contributes to further dehumanization and trauma, which is detrimental to the individual and to wider society. We find that one route toward revealing the extent of discrimination against incarcerated people, and beginning to make impactful, person-centered change, is focusing on full, safe, and dignified access to WaSH services.
Greenhouse gas emissions from inland water bodies and their rejuvenation: a review
Authors: Bhushan Amrendra , Goyal Vikas Chandra , Srivastav Arun Lal
Published: October 2024

Inland water bodies are observed as major sources of the emissions of greenhouse gases (GHGs) including carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O). This study shows that these entities (e.g. wetlands, constructed wetlands, reservoirs, lakes, ponds, and rivers) have a major contribution in GHG flux. However, understanding of the carbon dynamics of these water bodies is not well described. It was noticed that the emissions of GHGs from inland water bodies is a result of heavy supply of organic matter into them. Approximately 2.2–3.7% of the Earth's non-glaciated land area and inland waters are having almost similar amounts of carbon emission as also observed in the case of both net terrestrial productivity and net oceanic uptake. Wetlands and lakes are among the most studied water bodies. However, efforts should be made to understand the emission dynamics from ponds and rivers as recent studies say these are also among the potent sources of GHG emissions in the atmosphere. This review paper aims to highlight and give an elaborate insight into the contribution of inland waters to the global carbon cycle along possible remediative measures.
“Acid-catalyzed” Synthesis of bis(indolyl)methanes
Authors: Pawar Shraddha Subhash , Chatterjee Rana , Dandela Rambabu
Published: October 2024

The synthesis of bis-indole methanes (BIMs) is a significant area of research in organic chemistry
due to their diverse biological activities and applications in pharmaceuticals. This review focuses on the acidcatalyzed
synthesis of BIMs, offering a comprehensive overview of various catalytic systems, reaction mechanisms,
and optimization strategies. Acid catalysts, including Bronsted, Lewis acids, solid acids, and homogeneous
acids, play a crucial role in facilitating the formation of BIMs through electrophilic substitution reactions.
The review insights into different acid catalysts, such as Meldrum's acid, boric acid, and various solid
acids, and highlights their efficiency, selectivity, and environmental impact. Additionally, the influence of reaction
conditions, such as temperature, solvent selection, and substrate concentration, on the yield and purity of
BIMs are discussed. Moreover, recent advances in green chemistry approaches, including using recyclable and
solid acid catalysts, are explored. This comprehensive study aims to provide insights into the optimization of
acid-catalyzed BIM synthesis, paving the way for future developments in synthesizing biologically relevant
indole derivatives.
Fast Declining Prediction in Alzheimer’s Disease from Early Clinical Assessment
Authors: Alvarez-Sanchez Lourdes , Pereto Mar , Garcia-Valles Lorena , Balaguer Angel , Pena-Bautista Carmen , Ferre-Gonzalez Laura , Baquero Miguel , Pericas Consuelo Chafer
Published: October 2024

Intoduction:

The heterogenicity in Alzheimer's Disease (AD) progression hinders individual
prognosis. The present work is an observational 2-year longitudinal study in patients with mild
cognitive impairment due to AD (n= 52, with positive CSF biomarkers). The aim of this study is to
predict which patients are at risk of fast progression. For this, 3 neuropsychological tests based on
different domains (clinical dementia, cognition, delayed memory) and the sum of them were used.

Methods:

The tests were performed at diagnosis time (T1) and two years after the diagnosis time
(T2). Then, the corresponding progression models were developed using each individual test and
their sum as a variable response.

Results:

As a result, the model based on cognition status to predict fast decline (differences in the Z
score (T2-T1) <1.5 were considered fast declining) provided satisfactory performance (AUC 0.74,
83.3% of sensibility and 70.2% of specificity); the models based on clinical dementia and delayed
memory to predict fast declining showed low AUC and sensitivity. Nevertheless, the model based on
the sum of the 3 tests showed the highest AUC (0.79), low sensitivity (63.6%), and high specificity.

Conclusion:

The developed progression models could provide useful information to clinicians and
AD patients regarding their fast/normal decline in general or specific domains.
Concurrent Estimation of Pregabalin and Etoricoxib by New Stability-Indicating RP-UPLC Approach - Application in Assay of Commercial Tablets
Authors: Ponnekanti Krishnaphanisri , Godela Ramreddy
Published: October 2024

Background:

The study emphasizes establishing a stability-indicating RP-UPLC
method for concurrent estimation of pregabalin and etoricoxib in combined pharmaceutical formulations,
confirming effective separation, sensitivity, and repeatability, validated according to ICH
guidelines.

Objective:

The present research study aims to establish a new stability-indicating RP-UPLC
method for concurrently estimating pregabalin and etoricoxib in blended powder and their combined
tablet formulation with less run time, high sensitivity, and specificity.

Methods:

The effective separation of pregabalin and etoricoxib was achieved with HSS column
C18 (150x2.1mm,1.8μm), 0.1% orthophosphoric acid:acetonitrile (65:35 v/v) at a flow rate of
0.3mL/min, and isocratic elution at 228nm. The elution of PRB and ETB was noticed at 1.56 and
2.01 minutes, with good resolution and system suitability with the developed approach.

Results:

Pregabalin and etoricoxib have shown linear responses from 18.75 to 112.5μg/mL and 15
to 90μg/mL, respectively. The range of the % RSD for intraday and inter-day precision was 0.33
to 0.81. The LOD and LOQ of pregabalin and etoricoxib were computed to be 0.07 μg/mL and
0.21 μg/mL, and 0.01μg/mL and 0.04 μg/mL, respectively, by standard deviation method. The
validation method was carried out using ICH standards. The stability-indicating feature of the
method was confirmed by the forced degradation studies where degradants generated by stress testing
were clearly distinguished from the peaks of analytes.

Conclusion:

The shorter elution period and superior sensitivity of both analytes with this method
have been found to be appropriate for regular analysis of pregabalin and etoricoxib.
Selinexor as a Therapeutic Target: Advances in Non-small Cell and Small Cell Lung Cancer Treatment Strategies
Authors: Zheng Bosheng , Zhang Wenqi , Xie Shaonan , Han Yaqing , Liu Guangjie , Liu Yanjie , Gao Maogang , Wang Shize , Liu Qingyi
Published: October 2024

Selinexor treats lung cancer, particularly non-small cell lung cancer (NSCLC) and
small cell lung cancer (SCLC). This review summarizes the prevalence and types of lung cancer
and emphasizes the challenges associated with current treatments like resistance and limited effectiveness.
Selinexor is a selective inhibitor of nuclear export (SINE) that has emerged as a potential
therapy that targets the nuclear export of tumor suppressor proteins. The mechanisms of selinexor,
its potential in combination therapies, and challenges like side effects and drug resistance are explained
in this review. Key findings highlight the effectiveness of selinexor in preclinical studies,
particularly against KRAS-mutant NSCLC and in combination with chemotherapy for SCLC. The
review concludes with a discussion of future directions and underscores the potential of selinexor
to improve the treatment strategies for lung cancer.
Exploring Therapeutic Strategies: The Relationship between Metabolic Disorders and FOXO Signalling in Alzheimer's Disease
Authors: Kaur Parneet , Khan Heena , Grewal Amarjot Kaur , Dua Kamal , Singh Sachin Kumar , Gupta Gaurav , Singh Thakur Gurjeet
Published: October 2024

Alzheimer’s disease is an ailment that is linked with the degeneration of the brain cells,
and this illness is the main cause of dementia. Metabolic stress affects the activity of the brain in AD
via FOXO signaling. The occurrence of AD will significantly surge as the world’s population ages,
along with lifestyle changes perceived in current decades, indicating a main contributor to such
augmented prevalence. Similarly, metabolic disorders of current adulthood, such as obesity, stroke,
and diabetes mellitus, have been observed as the risk-causing factors of AD. Environmental influences
induce genetic mutations that result in the development of several diseases. Metabolic disorders
develop when individuals are exposed to an environment where food is easily accessible and
requires minimal energy expenditure. Obesity and diabetes are among the most significant worldwide
health concerns. Obesity arises because of an imbalance between the amount of energy consumed
and the amount of energy expended, which is caused by both behavioral and physiological
factors. Obesity, insulin resistance syndrome, hypertension, and inflammation are factors that contribute
to the worldwide risk of developing diabetes mellitus and neurodegenerative diseases. FOXO
transcription factors are preserved molecules that play an important part in assorted biological progressions,
precisely in aging as well as metabolism. Apoptosis, cell division and differentiation, oxidative
stress, metabolism, and lifespan are among the physiological processes that the FOXO proteins
are adept at controlling. In this review, we explored the correlation between signaling pathways
and the cellular functions of FOXO proteins. We have also summarized the intricate role of
FOXO in AD, with a focus on metabolic stress, and discussed the prospect of FOXO as a molecular
link between AD and metabolic disorders.
Role of Herbalism in Systemic Lupus Erythematosus Treatment
Authors: Aboulwafa Maram M. , Aly Shaza H. , AbouZid Sameh , Eldahshan Omayma A. , Singab Abdel Nasser B.
Published: October 2024

The well-known inflammatory and autoimmune condition known as
systemic lupus erythematosus (SLE) causes symptoms in the kidneys, the skin, the
brain, and the heart. It can also cause complications that affect several organs. The
diversity in organ involvement and heterogeneous conditions of patients led to the
complicated management of SLE. Increasingly, there is evidence highlighting the
importance of phytochemicals in both dietary and non-dietary contexts in the
management of SLE without side effects.Herein, we discuss the role of different plant extracts with their metabolites and their
modes of action against SLE updated to 2023, in addition to the incorporation of herbal
formulas in the management of the SLE. The present work is an overview of different
plant extracts and their secondary metabolites with significant anti-inflammatory,
antioxidant, and immunomodulation in SLE. The current chapter focuses on the various
targets, mechanisms, and pathways of natural products that manage SLE. Based on the
current work, it can be inferred that natural products show potential as effective agents
in the medical care of SLE.
Traditional Medicine and Modern Drug Delivery Systems: Promising Roles of PhytoNanotechnology in Rheumatoid Arthritis Treatment
Authors: Ilhan Miray , Ozturk Maide
Published: October 2024

Phyto-nanotechnology presents a promising avenue for revolutionizing
rheumatoid arthritis (RA) treatment. By integrating plant-derived compounds with
nanotechnology, this approach addresses the limitations of conventional RA therapies.
Nanoformulations of phytochemicals, such as curcumin, resveratrol, and quercetin,
enable targeted drug delivery to inflamed joints, optimizing therapeutic efficacy while
minimizing systemic side effects. Enhanced bioavailability, attributed to the
encapsulation of phytochemicals within nanoparticles, facilitates improved
pharmacokinetics and delivery across biological barriers. The immunomodulatory and
anti-inflammatory properties of phytochemicals are harnessed more effectively through
nanoparticle-mediated sustained release, offering the potential to suppress
inflammatory processes and mitigate joint damage. Furthermore, the cartilageprotective and regenerative capabilities of certain plant-derived compounds can be
optimized with nanotechnology, promoting joint health. The versatility of phytonanotechnology allows for combination therapies, synergizing the benefits of multiple
compounds and conventional drugs within nanoparticles. While these advancements
hold substantial promise, further research is imperative to refine nanoparticle
formulations, assess safety, and validate efficacy through preclinical and clinical
studies, ultimately paving the way for transformative RA treatments in clinical practice.
In this chapter, phyto-nano drug delivery systems that can increase the effectiveness of
medicinal plants in RA treatment are focused on.
Vitamin D and Insulin Resistance
Authors: Kalsekar Anam Shakil , Afrin Amina , Jalal Khawla , Papandreou Dimitrios
Published: October 2024

This chapter examines the latest research findings on the association
between vitamin D levels and insulin resistance (IR) in various populations, including
pregnant and postpartum women, children and adolescents, and individuals with certain
health conditions such as diabetes, obesity, multiple sclerosis (MS), polycystic ovary
syndrome (PCOS), non-alcoholic fatty liver disease (NAFLD), diabetic kidney disease
(DKD), and diabetic peripheral neuropathy (DPN). Existing evidence suggests that
Vitamin D plays a crucial role as an immunomodulator, affecting important human
disorders like insulin resistance, glucose homeostasis, and mineral and bone
metabolism. Extensive evidence suggests that vitamin D has a substantial impact on the
development of insulin resistance (IR), through its influence on different gene variants
related to vitamin D and the metabolic and immunological pathways associated with it.
Supplementing with vitamin D can be beneficial in properly managing and enhancing
insulin resistance. Diverse research approaches have yielded both favorable and
unfavorable results on the correlation between vitamin D and insulin resistance (IR).
Further research is recommended to clarify the correlation between vitamin D and
insulin function, as well as to determine any variations in this association among
different age groups, genders, and illnesses.
Infantile Intraparenchymal Brain Abscess due to Streptococcus pyogenes
Authors: Kıymaz Meltem , Alkan Gülsüm , Özyalvaç Büşra , Yücel Ayşe Gül , Öztürk Mehmet , Uygun Saime Sündüs , Konak Murat , Karaoğlu Gündoğdu Derya , Emiroğlu Melike
Published: October 2024

Introduction
Group A ß-hemolytic streptococcus (GABHS) are the most common bacterial cause of tonsillitis, and can cause noninvasive diseases such as pharyngitis and impetigo, as well as more severe invasive diseases. The incidence of invasive disease is 1-3/100,000 per year, and the morbidity and mortality rate is high. GABHS is rarely lead to brain abscesses.

Case Report
Acute phase reactants were found to be high in a 40-day-old patient who presented with fever, irritability and focal seizures. Acute phase reactants were high. Transfontanel ultrasonography showed increased thickness, echo and blood supply in the meninges. Brain magnetic resonance imaging (MRI) and diffusion MRI revealed a thick-walled abscess in the right cerebral hemisphere and parietooccipital parenchyma with diffusion restriction on diffusion-weighted images. Cerebrospinal fluid (CSF) polymerase chain reaction (PCR) test revealed S. pyogenes,and S. pyogenes grown in CSF culture. Initially, meropenem, vancomycin, metronidazole antibiotherapy was applied. Treatment was revised to cefotaxime and vancomycin after culture antibiogram and was completed for 8 weeks. Seizures regressed. Control brain imaging showed improvement. Restriction in left lower extremity movements remained. Physical therapy and rehabilitation was recommended and he was discharged.
Conclusion
GABHS, which is the causative agent of acute tonsillitis, rarely causes invasive disease which has high mortality and morbidity.
DAMPAK PEMBANGUNAN MANUSIA, KEMISKINAN DAN PENGANGGURAN TERHADAP PERTUMBUHAN EKONOMI TAHUN 2017-2021 DI JAWA TIMUR
Authors: Wisdawan Kukuh Tri , Pratomo Devanto Shasta
Published: October 2024

Economic growth is the development of economic activities that cause changes in the goods and services produced in everyday life. The level of economic growth in a region shows the level of change in the economic welfare of its people. East Java Province is one of the contributors to economic growth that is comparable to the national level. The amount of economic growth in a region can be influenced by several factors, namely: human development, poverty and unemployment. This research aims to identify and analyze the influence of human development, poverty levels and unemployment levels on economic growth in East Java Province. Based on the objectives to be achieved by the author, the type of research that will be used is panel data regression in the 2017-2021 time period. The research results show that human development has a positive and significant effect on economic growth, the poverty level has a positive and significant effect on economic growth, while the unemployment rate has a negative and insignificant effect on economic growth. However, human development, poverty and unemployment together have an influence on economic growth.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI TINGKAT PENGANGGURAN TERBUKA DI JAWA TIMUR 2012-2022
Authors: Kerina Della Puspita  , Moh. Athoillah
Published: October 2024

East Java Province has the second population density after West Java Province. This number of population can certainly be an advantage with abundant human resources or problems related to employment. This research is to find out and analyze the effect of minimum wages, population, HDI, PMTB, economic growth, and the agricultural sector has an open response rate in 38 districts/cities of East Java Province in 2012-2022. This study uses quantitative research with panel data models. The results of the research show that the data is free from classical assumption problems with the minimum wage variable having a significant positive influence, the population variable and the agriculture, forestry and fisheries variables having an insignificant and positive influence, the HDI and PMTB variables having a significant negative influence, the economic growth variable having the influence is insignificant and negative.
DETERMINAN YANG MEMPENGARUHI KEMISKINAN DI PULAU JAWA (PERSPEKTIF TEORI PRO-POOR GROWTH & HUMAN CAPITAL)
Authors: Fauziah Nurafikatul
Published: October 2024

Despite being the economic and governmental center, the number of impoverished people in Java Island exceeds half of the total impoverished population in Indonesia. Based on this, this research aims to examine the determinants influencing poverty in Java Island, covering 6 provinces during the period 2015-2022, based on the perspectives of pro-poor growth theory and human capital. The data used is sourced from BPS and employs panel data analysis techniques with a fixed-effect model. The research findings indicate that, individually, education and unemployment do not have a significant impact on poverty. Meanwhile, economic growth and the Human Development Index (HDI) have a negative and significant impact on poverty in Java Island. Simultaneously, economic growth, education, HDI, and unemployment collectively influence poverty in Java Island.
ANALISIS PENGARUH IPM, UPAH MINIMUM, TPT DAN BANTUAN SOSIAL TERHADAP TINGKAT KEMISKINAN DI PROVINSI JAWA TIMUR TAHUN 2017-2022
Authors: Riyandini Shafa
Published: October 2024

Poverty is a social problem that arises in economic development and can cause other problems. Therefore, there is a need for solutions to overcome the problem of poverty. This study aims to determine the role of Human Development Index (HDI), Open Unemployment Rate, minimum wage and social assistance spending on poverty rate in East Java. The sample of this study is 34 regencies and cities in East Java Province during 2017-2022. In this study, only 34 districts and cities were used because there were two cities that did not have the realization of social assistance spending. The data used in this study is secondary data sourced from BPS and DJPK of the Ministry of Finance. The method used is panel data regression with FEM (Fixed Effect Model). The results of this study show that each HDI has a significant negative effect and TPT has a significant positive effect on the poverty rate in East Java Province in 2017-2022. Meanwhile, the Minimum Wage and Social Assistance respectively have no significant effect on the poverty rate in East Java Province in 2017-2022.
Utilization of golden1000 application for exclusive breastfeeding success in stunting prevention efforts
Authors: Imaniar Melsa Sagita , Nurdianti Dewi , Rahmah Aulia
Published: October 2024

Background :Stunting is a developmental growth disorder experienced by children due to poor nutrition, recurrent infections, inadequate psychosocial stimulation, and the child's height for his age is below the average of SD STKA WHO. Indonesia has a prevalence of 36.4%. Stunting prevention involves priority interventions, namely specific nutrition interventions and sensitive interventions. Exclusive breastfeeding, including specialized interventions, plays a very important role in preventing stunting. Indonesia's Health Profile in 2019, Indonesia's exclusive breastfeeding coverage is 37.3%, while the national target is 80%, West Java 57.9% and Tasikmalaya City 56.0%, of course this will cause problems in the future related to stunting events, especially in cities. Tasikmalaya. The current problem is the low access to information obtained by mothers in increasing knowledge and literacy about breastfeeding. As an innovative product, it is used as an educational medium about breastfeeding preparation, breastfeeding attachment positions, problems and solutions in breastfeeding, breastfeeding tutorial videos and breastfeeding management as well as online consultations with breastfeeding counselors.

Objectives : The purpose of this study is the influence of the golden1000 application to increase maternal efficacy literacy related to breastfeeding so that it can be successfully breastfed exclusively.

Methods : This study uses a quasi-experimental design method, with a posttest only control group design approach. In this study, the treatment group was given an intervention in the form of the golden1000 menu application about breastfeeding including an educational menu about breastfeeding, video tutorials on attachment positions and an online consultation feature with a breastfeeding counselor for pregnant women in the third trimester up to 6 months of breastfeeding.

Results : The results of the study found that there was a statistically different difference in the success of exclusive breastfeeding between the golden1000 application group and the KIA book group.

Conclusions : The use of the golden1000 application can increase the success of breast milk givers exclusively.
ANALYSIS OF THE RELATIONSHIP BETWEEN TREATMENT PATTERNS BASED ON PATIENT CHARACTERISTICS IN CASES OF HYPERTENSION COMPLICATIONS AT PKU MUHAMMADIYAH GAMPING HOSPITAL
Authors: Ariansyah Diffa Zahra , Wulandari Ari Susiana , - Daru Estiningsih , - Eva Nurinda
Published: October 2024

Background   : Hypertensive disease is often referred to as "The Silent Disease" or silent disease. The percentage of complication hypertension in Indonesia is cerebrovascular disease 21.6%, heart disease 40.9%, and kidney disease 33.2%. Yogyakarta is one of the provinces in Indonesia with a prevalence of complication hypertension of 32.86%. Each year, an estimated 9.4 million people die from hypertension and complications.

Objective        : To analyze the relationship between treatment patterns based on sociodemographic characteristics in complication hypertensive patients in Inpatient PKU Muhammadiyah Gamping Hospital.

Methods: This study was analytical research methods using retrospective methods. The sampling technique was in this study is the total sampling technique. The variables used in this study were patterns of antihypertensive drug use associated with sociodemographic factors including gender, age, and patient health insurance (BPJS or non-BPJS). The test analysis was Chi-Square Test and Kendall's tau-b Test for variable blood pressure relationships and drug use patterns.

Results: Sociodemographic characteristics of respondents include: adult age (16.7%) and elderly (83.3%), male and female gender (50.0%), BPJS treatment coverage (91.7%) and general (8.3%). Hypertensive disease complications include: stroke (20.8%), myocardial infarction (4.2%), kidney failure (4.2%), heart failure (33.3%), diabetes mellitus (37.5%). Drugs used: Amlodipine (23.10%), Candesartan (30.80%), Nifedipine (11.50%), Bisoprolol (19.20%), Clonidin (5.80%), Captopril (1.90%), Lisinopril (3.80%), and Ramipril (3.80%).
Conclusion: There was no relationship between sociodemographic characteristics and treatment patterns and there was a relationship between systolic / diastolic blood pressure with drug use patterns in cases of complication hypertension at PKU Muhammadiyah Gamping Hospital.
Socio-Cultural Relationship to Self-Efficacy of Breastfeeding in Pregnant Women in the 3rd Trimester in the Working Area of Imogiri Ist Health Center and Kretek Community Health Center, Bantul Regency
Authors: Sulistiawati Sulistiawati , Dian Ayuningrum Lia , Dwiarini Muafiqoh , Lestari Prasetya , Worawong Chiraporn
Published: October 2024

Background: Socio-cultural factors, especially in Javanese society very influence the success and failure of exclusive breastfeeding. Social culture can be in customs, traditions, taboos, etc. Breastfeeding mothers who have low breastfeeding self-efficacy when they later face problems while breastfeeding will tend to make it easier to decide to use alternative techniques for breastfeeding their babies.

Objective: To determine the socio-cultural relationship towards breastfeeding self-efficacy in third-trimester pregnant women

Method: The type of research is a quantitative analytical descriptive. Data collection methods use surveys, observations, or interviews with a cross-sectional approach method. The sampling technique used purposive sampling of as many as 126 respondents with a gestational age of >30 weeks and according to the inclusion criteria. There are 2 instruments used, namely Sociocultural and Breastfeeding Self-efficacy Scale-Short Form (BSES-SF)

Results: Based on research conducted on 126 respondents, Social Culture Supports ( 0.000 < 0.05) and Social Culture Does Not Support (0.009 < 0.05) from the Chi-Square test with value 0,000  (p > 0.05) H a rejected means it shows that there is a significant relationship between social culture and breastfeeding self-efficacy.  The Breastfeeding Self-Efficacy Score showed that most respondents had high self-confidence ( 82.5 % ).

Conclusion: There is a significant relationship between social culture and breastfeeding self-efficacy. In this study, it can be said that respondents in the research area do not have traditions, culture, and taboos that do not support breastfeeding. The majority of respondents with supportive social culture (95%) have high breastfeeding self-efficacy (73%) with quite a large difference from moderate and very low breastfeeding self-efficacy (27%)