bluuebunny/crossref_metadata_2025 huggingface dataset:
Achilles tendon resting angle is able to detect deficits after an Achilles tendon rupture, but it is not a surrogate for direct measurements of tendon elongation, function or symptoms
Authors: Larsson Elin , Helander Katarina Nilsson , Falkheden Henning Lotta , Heiskanen Mervi , Carmont Michael R. , Grävare Silbernagel Karin , Brorsson Annelie
Published: September 2022

Purpose

The aim of this study was to investigate how the Achilles tendon resting angle (ATRA), an indirect measurement of tendon elongation, correlates with ultrasonography (US) measurements of the Achilles tendon length 6 and 12 months after an acute ATR and relates to other clinical outcome measurements such as heel-rise height, jumping ability and patient-reported outcome measurements (PROMs).

Methods

Patients were included following acute Achilles tendon rupture (ATR). Achilles tendon length, ATRA, heel-rise height (HRH), drop countermovement jump (Drop CMJ) and PROMs (Achilles tendon total rupture score (ATRS) and physical activity scale (PAS)) were evaluated 6 and 12 months after injury. Achilles tendon length was evaluated using US, while the ATRA was measured with a goniometer.

Results

Sixty patients (13 women, 47 men), mean (SD) age 43 (9) years, with an acute ATR undergoing either surgical (35%) or non-surgical (65%) treatment were evaluated. A negative correlation (r = − 0.356, p = 0.010) between relative ATRA and tendon elongation was seen at 12 months after ATR. There were also significant positive correlations at 6 and 12 months between relative ATRA and HRH (r = 0.330, p = 0.011 and r = 0.379, p = 0.004). There were no correlations between ATRA and ATRS or ATRA and Drop CMJ, at either 6 or 12 months after the injury.

Conclusion

In combination with other clinical evaluations such as HRH and US, ATRA could be a clinical tool for indirect measurements of tendon elongation. However, ATRA cannot be recommended as a direct surrogate for US for determining Achilles tendon length.

Level of evidence

III.
Mechanically aligned total knee arthroplasty with the extension-first technique does not equally restore neutral knee alignment in all preoperative knee phenotypes
Authors: Hörlesberger Nina , Zinggl Carina , Smolle Maria Anna , Leitner Lukas , Lohberger Birgit , Leithner Andreas , Sadoghi Patrick
Published: September 2022

Purpose

The aim of this study was to determine the change in the long leg axis according to the preoperative knee phenotype using the mechanically aligned extension-first technique in total knee arthroplasty. The hypothesis of this study was that the knee phenotype would have an impact on the postoperative leg axis.

Methods

This was a retrospective comparative study comprising 224 whole-leg radiographs of 112 patients. The leg axes of the pre- and postoperative radiographs were measured and categorized into three preoperative limb phenotypes (based on the hip-knee-ankle angle [HKA]) according to Hirschmann et al. (varus—HKA < 178.5°, neutral—HKA 178.5°–181.5°, and valgus—HKA > 181.5°). Additionally, femoral phenotypes (based on the femoral mechanical angle [FMA], i.e., the mechanical medial distal femoral angle [mMDFA], as well as the tibial phenotypes [based on the tibial mechanical angle, i.e., the medial proximal tibial angle (MPTA)] was calculated. The change in the long leg axis was analyzed and compared with the preoperative limb phenotype.

Results

Significantly more patients with preoperative varus alignment shifted to neutral alignment (46.3%, n = 31) than did patients with preoperative valgus alignment (38.9%; n = 14). Moreover, 43.3% of patients (n = 29) with the varus phenotype remained in a varus alignment, compared with the 58.3% of patients with preoperative valgus phenotype (n = 21) remaining in valgus alignment. These findings were similar for both females (p < 0.001) and males (p = 0.015).

Conclusion

Using an extension-first mechanically aligned surgical technique, varus phenotypes predominantly result in neutral leg axes or remain varus, neutral phenotypes remain neutral, and valgus phenotypes remain valgus or change to neutral phenotypes. This study showed that preoperative knee phenotypes in valgus knees influence this technique more strongly than estimated in previous investigations, which is in line with modern alignment philosophies for TKA.

Level of evidence

Level IV, retrospective comparative study.
Effect of phytate on hypercalciuria secondary to bone resorption in patients with urinary stones: pilot study
Authors: Guimerà Jordi , Martínez Ana , Bauza Jose Luis , Sanchís Pilar , Pieras Enrique , Grases Felix
Published: September 2022

The objective is to evaluate the effect of phytate supplements on calciuria in patients with urinary stones and elevated bone resorption. The secondary objective is to analyze the therapeutic effect of phytate based on measurements of serum markers of bone resorption. This is a controlled randomized study included patients according to predefined inclusion and exclusion criteria, and randomized them into two groups. Patients in the phytate group received a 380 mg capsule of calcium-magnesium InsP6 (Salvat Laboratories®) every 24 h for 3 months and patients in the control group received no treatment. All included patients were male or female, 18–65 years old, had hypercalciuria (> 250 mg/24 h), had a ß-Crosslaps level greater than 0.4 ng/mL, and had bone densitometry results indicative of osteopenia or osteoporosis in the femur and/or spine. At study onset, calciuria was 321 ± 52 mg/24 h in the phytate group and 305 ± 57 mg/24 h in the control group (p > 0.05). At 3 months, calciuria was significantly lower in the phytate group than the control group (226 ± 45 mg/24 h vs. 304 ± 58 mg/24 h, p < 0.05). At study onset, the mean ß-CrossLaps level was 1.25 ± 0.72 ng/mL in the phytate group and 0.57 ± 0.13 ng/mL in the control group (p < 0.05). However, at 3 months, the ß-CrossLaps level was significantly lower in the phytate group than in the control group (0.57 ± 0.13 ng/mL vs. 0.77 ± 0.42 ng/mL, p < 0.05). Phytate reduced calciuria in patients with hypercalciuria secondary to bone resorption. The ß-CrossLaps assay was effective for evaluating the efficacy of phytate on hypercalciuria during follow-up.
Comparison of physician and artificial intelligence-based symptom checker diagnostic accuracy
Authors: Gräf Markus , Knitza Johannes , Leipe Jan , Krusche Martin , Welcker Martin , Kuhn Sebastian , Mucke Johanna , Hueber Axel J. , Hornig Johannes , Klemm Philipp , Kleinert Stefan , Aries Peer , Vuillerme Nicolas , Simon David , Kleyer Arnd , Schett Georg , Callhoff Johanna
Published: September 2022

Symptom checkers are increasingly used to assess new symptoms and navigate the health care system. The aim of this study was to compare the accuracy of an artificial intelligence (AI)-based symptom checker (Ada) and physicians regarding the presence/absence of an inflammatory rheumatic disease (IRD). In this survey study, German-speaking physicians with prior rheumatology working experience were asked to determine IRD presence/absence and suggest diagnoses for 20 different real-world patient vignettes, which included only basic health and symptom-related medical history. IRD detection rate and suggested diagnoses of participants and Ada were compared to the gold standard, the final rheumatologists’ diagnosis, reported on the discharge summary report. A total of 132 vignettes were completed by 33 physicians (mean rheumatology working experience 8.8 (SD 7.1) years). Ada’s diagnostic accuracy (IRD) was significantly higher compared to physicians (70 vs 54%, p = 0.002) according to top diagnosis. Ada listed the correct diagnosis more often compared to physicians (54 vs 32%, p < 0.001) as top diagnosis as well as among the top 3 diagnoses (59 vs 42%, p < 0.001). Work experience was not related to suggesting the correct diagnosis or IRD status. Confined to basic health and symptom-related medical history, the diagnostic accuracy of physicians was lower compared to an AI-based symptom checker. These results highlight the potential of using symptom checkers early during the patient journey and importance of access to complete and sufficient patient information to establish a correct diagnosis.
Implementation in strong core by codes of rights
Authors: Lombardi Michele , Savva Foivos , Zivanas Nikolas
Published: September 2022

Following the seminal contribution of Koray and Yildiz (J Econ Theory 176:479–502, 2018), we re-examine the classical questions of implementation theory under complete information in a setting where coalitions are fundamental behavioral units, and the outcomes of their interactions are predicted by applying the solution concept of the strong core. The planner’s exercise includes designing a code of rights that specifies the collection of coalitions having the right to block one outcome by moving to another. We provide a complete characterization of the implementable social choice rules.
Stable isotope ratios of nitrogen and carbon as biomarkers of a vegan diet
Authors: Dierkes Jutta , Dietrich Stefan , Abraham Klaus , Monien Bernhard H. , McCann Adrian , Borgå Katrine , Weikert Cornelia
Published: September 2022

Purpose

Dietary biomarkers can potentially overcome the limitations of self-reported dietary data. While in ecology and archaeology, stable isotope ratios of carbon and nitrogen are widely used as biomarkers, this is not the case in nutrition research. Since the abundance of the 13C and the 15N isotope differ in food sources from plant and animal origin, stable isotope ratios of carbon and nitrogen (δ13C and δ15N) may differ in human biological material. Here, we investigated the stable isotope ratios of nitrogen and carbon in serum and urine from vegans and omnivores.

Method

Measurement of δ15N and δ13C in serum and 24 h urine was performed by Elemental Analyzer–Isotope Ratio Mass Spectrometer in the cross-sectional study “Risks and Benefits of a Vegan Diet”. The study included 36 vegans and 36 omnivores with a median age of 37.5 years (matched for age and sex), who adhered to their diet for at least 1 year.

Results

Both δ15N and δ13C were significantly lower in both the serum and 24 h urine of vegans compared to omnivores. δ15N either in serum or urine had 100% specificity and sensitivity to discriminate between vegans and omnivores. Specificity of δ13C was also > 90%, while sensitivity was 93% in serum and 77% in urine.

Conclusion

δ15N both in serum and urine was able to accurately identify vegans and thus appears to be a promising marker for dietary habits.
Neural Correlates of Oral Stereognosis—An fMRI Study
Authors: Schumann-Werner Beate , Schaefer Sinika , Schramm Silja , Patel Harshal Jayeshkumar , Binkofski Ferdinand Christoph , Werner Cornelius Johannes
Published: September 2022

Oral stereognosis is the ability to recognize, discriminate and localize a bolus in the oral cavity. Clinical observation indicates deficits in oral stereognosis in patients with vascular or neurodegenerative diseases particularly affecting the parietal lobes. However, the precise neural representation of oral stereognosis remains unclear whereas the neural network of manual stereognosis has already been identified. We hypothesize that oral and manual stereognosis share common neuronal substrates whilst also showing somatotopic distribution. Functional magnetic resonance images (fMRI; Siemens Prisma 3 T) from 20 healthy right-handed participants (11 female; mean age 25.7 years) using a cross-modal task of oral and manual spatial object manipulation were acquired. Data were analyzed using FSL software using a block design and standard analytical and statistical procedures. A conjunction analysis targeted the common neuronal substrate for stereognosis. Activations associated with manual and oral stereognosis were found in partially overlapping fronto-parietal networks in a somatotopic fashion, where oral stereognosis is located caudally from manual stereognosis. A significant overlap was seen in the left anterior intraparietal sulcus. Additionally, cerebellar activations were shown particularly for the oral condition. Spatial arrangement of shaped boli in the oral cavity is associated with neuronal activity in fronto-parietal networks and the cerebellum. These findings have significant implications for clinical diagnostics and management of patients with lesions or atrophy in parietal lobule (e.g. Alzheimer’s disease, stroke). More studies are required to investigate the clinical effect of damage to these areas, such as loss of oral stereognosis or an impaired oral phase.
Predictive risk factors of phenoconversion in idiopathic REM sleep behavior disorder: the Italian study “FARPRESTO”
Authors: Puligheddu Monica , Figorilli Michela , Antelmi Elena , Arnaldi Dario , Casaglia Elisa , d’Aloja Ernesto , Ferini-Strambi Luigi , Ferri Raffaele , Gigli Gian Luigi , Ingravallo Francesca , Maestri Michelangelo , Terzaghi Michele , Plazzi Giuseppe ,   and the FARPRESTO Consortium
Published: September 2022

Most patients with idiopathic REM sleep behavior disorder (iRBD) will develop an overt α-synucleinopathy over time, with a rate of phenoconversion of 73.5% after 12 years from diagnosis. Several markers of phenoconversion were identified; however, most studies investigated biomarkers separately, with retrospective study designs, in small cohorts or without standardized data collection methods. The risk FActoRs PREdictive of phenoconversion in idiopathic REM sleep behavior disorder: the Italian STudy (FARPRESTO) is a multicentric longitudinal retrospective and prospective study with a cohort of incident (prospective recruitment) and prevalent (retrospective recruitment) iRBD patients, whose primary aim is to stratify the risk of phenoconversion, through the systematic collection by means of electronic case report forms of different biomarkers. Secondary aims are to (1) describe the sociodemographic and clinical characteristics of patients with iRBD; (2) collect longitudinal data about the development of α-synucleinopathies; (3) monitor the impact of iRBD on quality of life and sleep quality; (4) assess the correlation between phenoconversion, cognitive performance, and loss of normal muscle atony during REM sleep; (5) identify RBD phenotypes through evaluating clinical, biological, neurophysiological, neuropsychological, and imaging biomarkers; and (6) validate vPSG criteria for RBD diagnosis. The FARPRESTO study will collect a large and harmonized dataset, assessing the role of different biomarkers providing a unique opportunity for a holistic, multidimensional, and personalized approach to iRBD, with several possible application and impact at different levels, from basic to clinical research, and from prevention to management. The FARPRESTO has been registered at clinicaltrials.gov (NCT05262543).
Evolution of the conceptualization of hydrogen through knowledge maps, energy return on investment (EROI) and national policy strategies
Authors: Guevara-Ramírez Willmer , Martínez-de-Alegría Itziar , Río-Belver Rosa María
Published: September 2022

In order to address Climate Change and energy dependency challenges, hydrogen (H2) is emerging as a promising energy carrier. Studies related to its production have conceptualized it as green (GH2), clean, renewable (RH2), ecological, and sustainable (SH2). The aim of this research is to deepen the understanding of the GH2 concept and to state boundaries between different terms. To reach this objective, a bibliometric analysis of publications indexed in SCOPUS is launched. Also, in order to assess the potential of renewable energy sources (RES) for GH2 production, a review of the meta-analysis literature on the Energy Return on Energy Invested (EROI) ratio as regards these RES is performed. Additionally, an analysis of main national strategies on GH2 is launched. Results indicate that the GH2 concept is gaining remarkable relevance, while the keyword maps show no significant differences between SH2, RH2 and GH2. EROI reveals low average values for the different biomass energy production processes. For their part, GH2 national strategies focus mainly on solar and wind technologies, albeit leaving the door open to biomass, where EROI could become an adequate metric to guide these strategies towards a low carbon energy path. Although the role of biomass may become fundamental in this energy transition process, given its low EROI values and considering that it is not a totally clean RES, it should be indexed as RH2, but not always as GH2. Finally, a proposal that guides a more appropriate use of the term GH2 is made.

Graphical abstract
Overexpression in metastatic breast cancer supports Syndecan-1 as a marker of invasiveness and poor prognosis
Authors: Cerbelli Bruna , Pisano Annalinda , Pignataro Maria Gemma , Pernazza Angelina , Botticelli Andrea , Carosi Mariantonia , Costarelli Leopoldo , Allegretti Matteo , d’Amati Giulia , Cordone Iole
Published: September 2022

Background

Metastasis is the main cause of breast cancer (BC) mortality. Increasing evidence points to a role of syndecan-1 (CD138) expression as a prognostic marker involved in BC tissue and leptomeningeal metastasis. Aim of this study was to investigate and compare syndecan-1 tissue expression and localization in primary and secondary BC, focusing on brain metastases.

Methods

Syndecan-1 expression was determined by immunohistochemistry. Focal vs diffuse (< or > 50% of cancer cells, respectively) pattern of expression, cellular localization (cytoplasm vs membrane) and intensity of immunostaining on neoplastic cells were evaluated. Moreover, the extent and pattern of expression of syndecan-1 were compared between primary tumors and paired metastases and correlated with the tumor intrinsic subtype.

Results

A total of 23 cases, 10 with paired primary and metastatic tumor and 13 brain metastases, were evaluated. Syndecan-1 was expressed in both primary and metastatic BC. A diffuse cytoplasmic expression was observed in most primary BCs; by contrast, all metastatic lesions showed a membrane pattern of expression, suggesting a shift in cellular localization of syndecan-1 during the metastatic process. Concerning the extent of expression, we observed in metastatic lesions, a trend of association between intrinsic subtypes and extent of positivity. In particular, both BC characterized by overexpression of HER2 and triple-negative tumors were correlated with a diffuse pattern of expression with a moderate to strong intensity.

Conclusion

A diffuse cytoplasmic expression was observed in most primary BCs; by contrast, all metastatic lesions showed a membrane pattern of expression, suggesting a shift in cellular localization of syndecan-1 during the metastatic process.
DoMoS − an open-source device for automated monitoring of endangered garden dormice (Eliomys quercinus)
Authors: Büchner Sven , von Thaden Alina , Braun Antonia , Drodofsky Paul , Heim Lars , Hill Padraig , Lang Johannes , Haalboom Thomas
Published: September 2022

Obtaining biological and behavioural data on wild animals in the field remains a challenging task. Data collection is either very labour-intensive or sometimes even proves impossible without special technical devices. This is especially true for small nocturnal mammals like the endangered garden dormouse (Eliomys quercinus). Here, we present a new device for automated small mammal monitoring, called DoMoS (Dormouse Monitoring System). It integrates the collection of individual hair samples for DNA analysis, a scale to measure body mass, and a camera trap to monitor activity. During a first field test with garden dormice, data on body mass and activity patterns and hair samples have been successfully collected. The system was designed as an open-source project and can thus be replicated and adjusted to other species’ monitoring needs and research questions. The DoMoS enables the study of various data, including the collection of DNA samples, without capturing the target species. Automatic data collection reduces stress for animals and researchers.
Application of the capture–recapture method to ascertain the completeness of the Saxon pediatric IBD registry in Germany
Authors: Li Shi , Kern Ivana , Manuwald Ulf , Kugler Joachim , Rothe Ulrike
Published: September 2022

Aim

The incidence of inflammatory bowel disease (IBD) is increasing worldwide. The Saxon Pediatric IBD Registry was founded in 2000 to describe the epidemiology of pediatric IBD in Germany. The aim of this study was to determinate the completeness of this registry for children and adolescents younger than 15 years and to make this approach transparent. Results of this completeness update have broad implications for further scientific publications from the registry dataset.

Method

The capture–recapture method with two data sources was used to ascertain completeness. A second data source was collected in 2019 for the observation period 2008–2014 from all pediatricians, gastroenterologists, and internists working in practices in a predefined region in Saxony, Germany.

Results

A total of 23 patients with IBD were reported who fulfilled the inclusion criteria. One of them was not recorded in the registry. Therefore, the completeness of the registry was estimated at 95.7% (95% CI 90.2–100). Initial analysis of the Saxon Pediatric IBD Registry over the 15-year period 2000–2014 includes 532 patients, 312 (58.6%) male and 220 (41.4%) female. The distribution of single IBD diseases in the registry was as follows: Crohn’s disease 338 patients (63.5%), ulcerative colitis 176 patients (33.1%), and unclassified IBD 18 patients (3.4%). Evaluations by sex and by disease in age groups and by age at onset were tabulated.

Conclusion

This study demonstrates that the completeness level of the Saxon Pediatric IBD Registry is high (95.7%), and thus the epidemiological data of the registry are reliable.
Basic practices for gastrointestinal ultrasound
Authors: Nishida Mutsumi , Hasegawa Yuichi , Hata Jiro
Published: September 2022

The standard diagnostic modalities for gastrointestinal (GI) diseases have long been endoscopy and barium enema. Recently, trans-sectional imaging modalities, such as computed tomography and magnetic resonance imaging, have become increasingly utilized in daily practice. In transabdominal ultrasonography (US), the bowel sometimes interferes with the observation of abdominal organs. Additionally, the thin intestinal walls and internal gas can make structures difficult to identify. However, under optimal US equipment settings, with identification of the sonoanatomy and knowledge of the US findings of GI diseases, US can be used effectively to diagnose GI disorders. Thus, the efficacy of GIUS has been gradually recognized, and GIUS guidelines have been published by the World Federation for Ultrasound in Medicine and Biology and the European Federation of Societies for Ultrasound in Medicine and Biology. Following a systematic scanning method according to the sonoanatomy and precisely estimating the layered wall structures by employing color Doppler make diagnosing disease and evaluating the degree of inflammation possible. This review describes current GIUS practices from an equipment perspective, a procedure for systematic scanning, typical findings of the normal GI tract, and 10 diagnostic items in an attempt to help medical practitioners effectively perform GIUS and promote the use of GIUS globally.
Two-bound core games and the nucleolus
Authors: Gong Doudou , Dietzenbacher Bas , Peters Hans
Published: September 2022

This paper introduces the new class of two-bound core games, where the core can be described by a lower bound and an upper bound on the payoffs of the players. Many classes of games turn out to be two-bound core games. We show that the core of each two-bound core game can be described equivalently by the pair of exact core bounds, and study to what extent the exact core bounds can be stretched while retaining the core description. We provide explicit expressions of the nucleolus for two-bound core games in terms of all pairs of bounds describing the core, using the Talmud rule for bankruptcy problems, and study to what extent these expressions are robust against game changes.
Beyond congruence: evidential integration and inferring the best evolutionary scenario
Authors: Nejad Kourki Arsham
Published: September 2022

Molecular methods have revolutionised virtually every area of biology, and metazoan phylogenetics is no exception: molecular phylogenies, molecular clocks, comparative phylogenomics, and developmental genetics have generated a plethora of molecular data spanning numerous taxa and collectively transformed our understanding of the evolutionary history of animals, often corroborating but at times opposing results of more traditional approaches. Moreover, the diversity of methods and models within molecular phylogenetics has resulted in significant disagreement among molecular phylogenies as well as between these and earlier phylogenies. How should this broad and multifaceted problem be tackled? I argue that the answer lies in integrating evidence to infer the best evolutionary scenario. I begin with an overview of recent development in early metazoan phylogenetics, followed by a discussion of key conceptual issues in phylogenetics revolving around phylogenetic evidence, theory, methodology, and interrelations thereof. I then argue that the integration of different kinds of evidence (e.g. molecular, morphological, ecological) is necessary for arriving at the best evolutionary scenario (causal explanation) rather than merely the best-fitting cladogram (statistical explanation). Finally, I discuss the prospects of this view in stimulating interdisciplinary cross-talk in early metazoan research and beyond, and challenges that need to be overcome.
A comparative analysis of recurrence risk predictions in ER+/HER2− early breast cancer using NHS Nottingham Prognostic Index, PREDICT, and CanAssist Breast
Authors: Gunda Aparna , Eshwaraiah Mallikarjuna S. , Gangappa Kiran , Kaur Taranjot , Bakre Manjiri M.
Published: September 2022

Aims

Clinicians use multi-gene/biomarker prognostic tests and free online tools to optimize treatment in early ER+/HER2− breast cancer. Here we report the comparison of recurrence risk predictions by CanAssist Breast (CAB), Nottingham Prognostic Index (NPI), and PREDICT along with the differences in the performance of these tests across Indian and European cohorts.

Methods

Current study used a retrospective cohort of 1474 patients from Europe, India, and USA. NPI risk groups were categorized into three prognostic groups, good (GPG-NPI index ≤ 3.4) moderate (MPG 3.41–5.4), and poor (PPG  > 5.4). Patients with chemotherapy benefit of < 2% were low-risk and ≥ 2% high-risk by PREDICT. We assessed the agreement between the CAB and NPI/PREDICT risk groups by kappa coefficient.

Results

Risk proportions generated by all tools were: CAB low:high 74:26; NPI good:moderate:poor prognostic group- 38:55:7; PREDICT low:high 63:37. Overall, there was a fair agreement between CAB and NPI[κ = 0.31(0.278–0.346)]/PREDICT [κ = 0.398 (0.35–0.446)], with a concordance of 97%/88% between CAB and NPI/PREDICT low-risk categories. 65% of NPI-MPG patients were called low-risk by CAB. From PREDICT high-risk patients CAB segregated 51% as low-risk, thus preventing over-treatment in these patients. In cohorts (European) with a higher number of T1N0 patients, NPI/PREDICT segregated more as LR compared to CAB, suggesting that T1N0 patients with aggressive biology are missed out by online tools but not by the CAB.

Conclusion

Data shows the use of CAB in early breast cancer overall and specifically in NPI-MPG and PREDICT high-risk patients for making accurate decisions on chemotherapy use. CAB provided unbiased risk stratification across cohorts of various geographies with minimal impact by clinical parameters.
Positive association between body height and breast cancer prevalence: a retrospective study with 135,741 women in Germany
Authors: Gremke Niklas , Griewing Sebastian , Kalder Matthias , Kostev Karel
Published: September 2022

Purpose

The aim of this study was to analyze the prevalence of breast cancer in relation to body height and to investigate associations between body height and breast cancer in Germany.

Methods

This retrospective cohort study included 135,741 adult women followed in one of 161 gynecology practices in Germany between January 2019 and December 2021. The 3 year prevalence of breast cancer (ICD-10: C50) during the study period was shown in relation to body height, which was included in this study as a five-category variable for women: ≤ 160 cm, 161–165 cm, 166–170 cm, 171–175 cm, > 175 cm. The associations between height and breast cancer were analyzed using logistic regression models adjusted for age and BMI.

Results

The prevalence of breast cancer increased from 5.1% in women ≤ 160 cm to 6.8% in women > 175 cm in the age group 51–60, and from 9.2% in women ≤ 160 cm to 12.2% in women 171–175 cm in the age group > 60 years. The OR for breast cancer was 1.18 (95% CI 1.12–1.24) for every 10 cm increase in height. Compared to height ≤ 160 cm, the OR for height 166–170 cm was 1.26 (1.15–1.39), for 171–175 cm 1.43 (1.27–1.61), and for > 175 cm 1.49 (1.28–1.74).

Conclusion

The results of this study suggest that greater body height in women is significantly related to an increased breast cancer risk.
Procurement for zero-emission construction sites: a comparative study of four European cities
Authors: Stokke Raymond , Qiu Xinlu , Sparrevik Magnus , Truloff Shannon , Borge Iselin , de Boer Luitzen
Published: September 2022

The public sector has a vital role in reducing emissions from construction activities and achieving environmental goals. Therefore, it is vital to investigate the opportunities for reducing the construction industry’s emissions through its procurement practices. This paper explores the opportunities and challenges of using green public procurement (GPP) to orchestrate stakeholder ecosystems, including public buyers, construction companies, subcontractors, and equipment suppliers, to achieve zero-emission construction sites—that is, ecosystems for zero-emission construction sites (EZEMCONS). The multiple case study methodology is employed to examine four European cities’ practices and experiences. The findings suggest that cities can improve low-emission machinery infrastructure, promote better networking for builders, and enhance cooperation through early market dialogues. Conversely, EZEMCONS pose challenges to innovation ecosystem (IE) orchestration, particularly when managing large-scale zero-emission infrastructure projects. Cities can use these findings to understand general IE implications for developing more mature EZEMCONS. More specifically, this study summarizes the potential opportunities and challenges of GPP for building mature IEs. GPP has been the subject of much environmental policy and sustainable production research; however, its application to EZEMCONS is limited. Consequently, this research contributes to the emergent literature on EZEMCONS, within the GPP context, by examining its opportunities and challenges.
Oocyte diameter predicts the maturation rate of human immature oocytes collected ex vivo
Authors: Pors S. E. , Nikiforov D. , Cadenas J. , Ghezelayagh Z. , Wakimoto Y. , Jara L. A. Z. , Cheng J. , Dueholm M. , Macklon K. T. , Flachs E. M. , Mamsen L. S. , Kristensen S. G. , Andersen C. Yding
Published: September 2022

Purpose

To study the impact of oocyte diameter and cumulus cell mass on the potential for final maturation of immature human oocytes in vitro.

Methods

Immature oocytes (n = 1563) from 75 women undergoing fertility preservation by ovarian tissue cryopreservation (14–41 years) were collected. After preparation of the ovarian cortex for freezing, immature oocytes were collected from the surplus medulla. After collection, IVM was performed according to standard published methods. The mass of cumulus cell surrounding the immature oocyte was grouped according to size. After IVM, each oocyte was photographed, measured, and the diameter was calculated as a mean of two perpendicular measurements.

Results

The diameter of the oocytes ranged from 60 to 171 µm with a mean of 115 µm (SD:12.1) and an interquartile range from 107 to 124 µm. The oocyte diameter was positively associated with a higher incidence of MII (p < 0.001). MII oocytes had a significantly larger mean diameter than MI, GV, and degenerated oocytes. The size of the cumulus cell mass was significantly associated with the MII stage (p < 0.001) and larger oocyte diameter (p < 0.001). The results further confirm that the diameter of the fully grown oocyte is reached relatively early in human follicular development and that the factors governing oocyte maturation in vitro are connected to the surrounding cell mass and the oocyte.

Conclusion

The diameter of the oocyte is a highly determining factor in the nuclear maturation of the human oocyte during in vitro maturation, and the size of the cumulus cell mass is closely positively associated with a larger diameter.
Progress of the ECHo SDR Readout Hardware for Multiplexed MMCs
Authors: Gartmann R. , Karcher N. , Gebauer R. , Krömer O. , Sander O.
Published: September 2022

The electron capture in $$^{163}$$

163

Holmium (ECHo) experiment seeks to achieve sub-eV sensitivity of the electron neutrino mass through calorimetric decay spectroscopy of $$^{163}$$

163

Ho in large arrays of cryogenic magnetic microcalorimeters (MMCs). Microwave SQUID multiplexing serves to efficiently increase the number of readout channels, thus calorimeters per array and ultimately per cryostat. A corresponding frequency multiplexing room temperature software-defined radio (SDR) system is in development to enable the readout of this increased number of MMCs per cable. The SDR consists of a custom FPGA platform that provides signal generation and analysis capabilities, as well as tailored signal conversion and analog conditioning front end electronics that enable the room-temperature-to-cryogenic interface. Ultimately, the system will read out 400 multiplexer channels with double pixel detectors through a bandwidth of 4 GHz (IEEE C band). As high-resolution data converters are limited in sample rate, the C-band is split into five sub-bands using a two-stage mixing method. In this contribution, a prototype of the heterodyne RF design is presented. It comprises one of the five 800 MHz sub-bands for a target frequency range between 4 and 8 GHz. Furthermore, the second version of the A/D converter stage is presented, capable of generating and digitizing up to five complex basebands using 1 GSs$$^{-1}$$

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1

converters, the reference clocks and a flux-ramp signal. We will show first results of their single and combined characterization in the lab. The current state of the prototype hardware enables preliminary measurements, only limited in bandwidth and with slightly higher noise. Potential improvements could be derived and will be implemented in the full bandwidth, 5-sub-band RF PCB design.
Up regulation of long non-coding RNAs BACE1 and down regulation of LINC-PINT are associated with CRC clinicopathological characteristics
Authors: Bakhtiari-Nezhad Sara , Rejali Leili , Hadizadeh Mahrooyeh , Taleghani Mohammad Yaghob , Aghdaei Hamid Asadzadeh , Young Chris , Khanabadi Binazir , Nazemalhosseini-Mojarad Ehsan , Bonab Maziar Ashrafian
Published: September 2022

Background

Long non-coding RNAs (LncRNAs) are known to have regulatory consequences for aberrant gene expression in cancers. The aim of this study was to evaluate the expression levels of long non-encoding RNAs, BACE1 (β-secretase1) and LINC-PINT (Long Intergenic Non-Protein Coding RNA, P53 Induced Transcript), in colorectal cancer (CRC) with clinicopathological parameters.

Methods and results

Bioinformatics analysis defining effectual signalling pathways Wnt. A total of 130 tissue samples (50 fresh CRC tissues with parallel adjacent normal tissues (ADJ) accompanied with 30 normal healthy control tissue samples) were collected from the Iranian population. mRNA expression analysis was performed via Real Time Q-PCR. Statistical analysis for comparing CRC expression levels with ADJ and normal healthy tissues were carried out using Kruskal–Wallis tests. The Receiver Operating Characteristic (ROC) curve was plotted for each LNC, separately. We discovered that PINT and BACE1 expression levels were decreased and increased respectively in CRC tumour samples compared with ADJ normal and healthy tissues. Clinicopathological parameter assessment revealed a significant relationship between PINT expression, tumour location, staging and distant metastasis (p < 0.009, p < 0.014, p < 0.008, respectively). Also, BACE1 over expression was significantly associated with tumour site (p < 0.009), metastasis (p < 0.017) and histological differentiation (p < 0.028) and staging (p < 0.017). Furthermore, ROC curve plotting showed LINC-PINT LNC-BACE1 may distinguish between early and late-stage of CRC, highlighting the value of both BACE1 and PINT as CRC progression biomarkers.

Conclusion

We investigated two LNCRNAs (PINT and BACE1) as potential CRC prognostic biomarkers, which are imperative for early and effective medical intervention in CRC. Expression levels of PINT and BACE1 in CRC tissue samples may serve to identify metastasis earlier, increasing patient survival rates and expediating clinical treatment options.
Effects of centrifugal stiffening and spin softening on nonlinear modal characteristics of cyclic blades with impact–friction coupling
Authors: She Houxin , Li Chaofeng
Published: September 2022

This paper aims to interpret the coupling modal properties of cyclic blades under impact–friction interactions and their evolution mechanism versus operating points. Therefore, a coupling analytical model of cyclic blades is developed based on a Lagrange method and the assumed mode method (AMM), after considering centrifugal stiffening, spin softening, stagger angle, and twist angle. Then a mixed modal analysis method (MMAM) for this analytical model is extended by combining the extended periodic motion concept (EPMC) with AMM. Wherein a classic alternating frequency/time method (AFT) and the continuation method are employed to overcome the numerical divergence problem. Then damped nonlinear normal modes (dNNMs), including eigenfrequencies, modal damping ratios, and mode shapes, of the coupling system with shroud joints are finally computed and discussed under different excitation levels and contact conditions through a modal synthesis algorithm. After that, the influence laws of centrifugal stiffening and spin softening on the dNNMs are explored to reveal its evolution mechanism versus operation speeds. Finally, the Campbell diagrams of dNNMs are successfully obtained to discuss the effects of the impact–friction coupling on critical speeds (CSs) of the shrouded blades system.
Representations and warranties insurance in mergers and acquisitions
Authors: Even-Tov Omri , Ryans James , Solomon Steven Davidoff
Published: September 2022

To mitigate information asymmetry in acquisitions, the seller makes contractual representations and warranties (referred to as “R&W” or “reps”) about the state of the target, such as attesting to the accuracy of the target’s financial statements. While seller indemnities allow buyers to impose costs due to breaches in the reps discovered after the deal’s close, these indemnities involve significant contracting costs. To mitigate these costs, the acquisition parties have increasingly turned to purchasing representations and warranties insurance. Using a proprietary and novel sample of R&W insurance policies issued worldwide for acquisitions of non-public targets, we find that the demand for R&W insurance, the premium charged for it, and the likelihood of a claim being filed are correlated with industry metrics for valuation uncertainty, the type of acquirer and seller, and the target’s legal regime. In particular, we find higher demand for R&W insurance and a higher R&W insurance premium charged when the target belongs to an industry with weaker internal controls. We also find that a higher premium is charged when the target is in an industry with relatively high levels of R&D to sales, indicating that the insurance company expects unrecognized intangible assets to have a greater risk of future claims. Our study adds to our understanding of how parties reduce target valuation uncertainty and the role of disclosures and R&W insurance policies in private mergers and acquisitions transactions.
Global expressivism and alethic pluralism
Authors: Price Huw
Published: September 2022

This paper discusses the relation between Crispin Wright’s alethic pluralism and my global expressivism. I argue that on many topics Wright’s own view counts as expressivism in my sense, but that truth itself is a striking exception. Unlike me, Wright never seems to countenance an expressivist account of truth, though the materials needed are available to him in his approaches to other topics.
Circulating redox status in sheep naturally infected with Trichophyton verrucosum
Authors: Saleh Mostafa A. , Rateb M. H. , Abd-Allah Elham A. , Mohamed Ghada A. E.
Published: September 2022

Trichophyton verrucosum is a zoophilic dermatophyte that causes skin inflammation. The present study aimed to evaluate the redox status in the blood of sheep clinically infected with T. verrucosum. According to clinical and mycological investigations, 48 juvenile male Balady sheep were selected in their natural habitat and divided into four groups depending on the lesion size: mild (MID), moderate (MOD), severe (SEV) T. verrucosum infection, and healthy control groups. Compared to the controls, plasma superoxide anion increased (P < 0.05) in both MOD and SEV but total peroxides (TPx) gradually increased (P < 0.05) in MID followed by MOD and SEV. Superoxide dismutase and total antioxidant capacity (TAC) were higher (P < 0.05) in MID and lower (P < 0.05) in MOD and SEV than in controls, but SEV showed lower TAC than MOD. Malondialdehyde (MDA, a lipid peroxide marker) increased (P < 0.05) in SEV than in controls, but protein carbonyl (PC, a protein peroxidation marker) was augmented (P < 0.05) as lesions progressed from mild to severe. The oxidative stress index (TPx/TAC ratio) progressively increased (P < 0.05) in MOD and SEV. The correlation of PC was positive with TPx and negative with TAC (P < 0.01). In conclusion, sheep infection with T. verrucosum is characterized by increased TPx and decreased TAC in plasma depending on the lesion area. The redox status is shifted towards the oxidizing state, particularly in MOD and SEV cases. This results in a condition of OS, which may contribute to the pathogenesis of the disease.
Integrating self-regulated learning and individual differences in the prediction of university academic achievement across a three-year-long degree
Authors: Pérez-González Juan-Carlos , Filella Gemma , Soldevila Anna , Faiad Yasmine , Sanchez-Ruiz Maria-Jose
Published: September 2022

The study investigated the joint contribution of the self-regulated learning (SRL) and individual differences approaches to the prediction of university students’ grade point average (GPA) obtained at three separate time points throughout their degree (3 years). We assessed cognitive (i.e., previous academic performance, cognitive ability, and cognitive SRL strategies) and non-cognitive variables (i.e., personality, trait emotional intelligence, motivation, and non-cognitive SRL strategies) in a sample of Spanish undergraduates. Results showed that GPA correlated with previous academic performance (i.e., combination of high school’s GPA and college admission test score), academic self-efficacy, academic engagement, SRL strategies, and conscientiousness. Hierarchical regression analyses indicated that non-cognitive factors (i.e., academic engagement, academic self-efficacy, regulation of behavior and context, and conscientiousness) alone explained 17–25% of the variance in GPA across three years, and previous academic performance accounted up to an additional 25% of the variance, jointly reaching an explained variance of up to 50% in GPA. Specifically, academic engagement and regulation of behavior and context demonstrated incremental validity over and above cognitive predictors such as previous academic performance, inductive reasoning and regulation of cognition and metacognition. The role of intelligence, whether cognitive or emotional, was not as obvious as a predictor. Two nested structural equation models explained about 27–29% of the variance in a latent GPA factor exclusively from a proxy of a global variable of non-cognitive factors as a latent predictor, which is a novel and promising proof of its robust criterion validity. Implications and recommendations for future studies are discussed.
Electromagnetic tool for the endoscopic creation of colon anastomoses—development and feasibility assessment of a novel anastomosis compression implant approach
Authors: Steger Jana , Zimmermann Anne , Wittenberg Thomas , Mela Petra , Wilhelm Dirk
Published: September 2022

Background

Colorectal anastomoses are among the most commonly performed interventions in abdominal surgery, while associated patient trauma is still high. Most recent trends of endoscopic anastomosis devices integrate magnetic components to overcome the challenges of minimally invasive surgery. However, the mutual attraction between magnetic implant halves may increase the risk of inadvertently pinching healthy structures. Thus, we present a novel anastomosis device to improve system controllability and flexibility.

Methods

A magnetic implant and an applicator with electromagnetic control units were developed. The interaction of magnetic implants with the electromagnets bears particular challenges with respect to the force-related dimensioning. Here, attraction forces must be overcome by the electromagnet actuation to detach the implant, while the attraction force between the implant halves must be sufficient to ensure a stable connection. Thus, respective forces were measured and the detachment process was reproducibly investigated. Patient hazards, associated with resistance-related heating of the coils were investigated.

Results

Anastomosis formation was reproducibly successful for an implant, with an attraction force of 1.53 $$\pm 0.3 N$$

±
0.3
N

, resulting in a compression pressure of $$0.0048 \frac{N}{{\mathrm{mm}}^{2}}$$

0.0048

N

mm

2

. The implant was reproducibly detachable from the applicator at the anastomosis site. Coils heated up to a maximum temperature of $${T}_{\mathrm{max}}=41.6 \pm 0.1^\circ \mathrm{C}$$

T
max

=
41.6
±
0
.

1
∘

C

. Furthermore, we were able to establish a neat reconnection of intestinal bowel endings using our implant.

Discussion

As we achieved nearly equal compression forces with our implant as other magnetic anastomosis systems did (Magnamosis™: 1.48 N), we concluded that our approach provides sufficient holding strength to counteract the forces acting immediately postoperatively, which would eventually lead to an undesired slipping of the implant halves during the healing phase. Based on heat transfer investigations, preventive design specifications were derived, revealing that the wall thickness of a polymeric isolation is determined rather by stability considerations, than by heat shielding requirements.