bluuebunny/crossref_metadata_2025 huggingface dataset:
Pulmonary artery catheter monitoring versus arterial waveform-based monitoring during liver transplantation: a retrospective cohort study
Authors: Jung Ji-Yoon , Sohn Jin Young , Lim Leerang , Cho Hyeyeon , Ju Jae-Woo , Yoon Hyun-Kyu , Yang Seong-Mi , Lee Ho-Jin , Kim Won Ho
Published: November 2023

Although pulmonary artery catheter (PAC) has been used during liver transplantation surgery, the usefulness of PAC has rarely been investigated. We evaluated whether the use of PAC is associated with better clinical outcomes compared to arterial waveform-based monitoring after liver transplantation. A total of 1565 cases undergoing liver transplantation were reviewed. We determined whether patients received PAC or not and divided our cohort into the PAC with hemodynamic monitoring using PAC and the non-PAC with arterial waveform-based monitoring using FloTrac-Vigileo. Propensity score matching was performed. Acute kidney injury (AKI), early allograft dysfunction (EAD) and 1-year all-cause mortality or graft failure were compared in the matched cohorts. Logistic regression analysis was performed in the inverse probability of treatment-weighted (IPTW) cohort for postoperative EAD and AKI, respectively. Five-year overall survival was compared between the two groups. In the matched cohort, there was no significant difference in the incidence of AKI, EAD, length of hospital or ICU stay, and 1-year all-cause mortality between the groups. In the IPTW cohort, the use of PAC was not a significant predictor for AKI or EAD (AKI: odds ratio (95% confidence interval) of 1.20 (0.47–1.56), p = 0.229; EAD: 0.99 (0.38–1.14), p = 0.323). There was no significant difference in the survival between groups after propensity score matching (Log-rank test p = 0.578). In conclusion, posttransplant clinical outcomes were not significantly different between the groups with and without PAC. Anesthetic management without the use of PAC may be possible in low-risk patients during liver transplantation. The risk should be carefully assessed by considering MELD scores, ischemic time, surgical history, previous treatment of underlying liver disease, and degree of portal and pulmonary hypertension.

Registration: https://clinicaltrials.gov/ct2/show/NCT05457114 (registration date: July 15, 2022).
Energy transfer in N-component nanosystems enhanced by pulse-driven vibronic many-body entanglement
Authors: Gómez-Ruiz Fernando J. , Acevedo Oscar L. , Rodríguez Ferney J. , Quiroga Luis , Johnson Neil F.
Published: November 2023

The processing of energy by transfer and redistribution, plays a key role in the evolution of dynamical systems. At the ultrasmall and ultrafast scale of nanosystems, quantum coherence could in principle also play a role and has been reported in many pulse-driven nanosystems (e.g. quantum dots and even the microscopic Light-Harvesting Complex II (LHC-II) aggregate). Typical theoretical analyses cannot easily be scaled to describe these general N-component nanosystems; they do not treat the pulse dynamically; and they approximate memory effects. Here our aim is to shed light on what new physics might arise beyond these approximations. We adopt a purposely minimal model such that the time-dependence of the pulse is included explicitly in the Hamiltonian. This simple model generates complex dynamics: specifically, pulses of intermediate duration generate highly entangled vibronic (i.e. electronic-vibrational) states that spread multiple excitons – and hence energy – maximally within the system. Subsequent pulses can then act on such entangled states to efficiently channel subsequent energy capture. The underlying pulse-generated vibronic entanglement increases in strength and robustness as N increases.
Increased functional connectivity in the right dorsal auditory stream after a full year of piano training in healthy older adults
Authors: Jünemann Kristin , Engels Anna , Marie Damien , Worschech Florian , Scholz Daniel S. , Grouiller Frédéric , Kliegel Matthias , Van De Ville Dimitri , Altenmüller Eckart , Krüger Tillmann H. C. , James Clara E. , Sinke Christopher
Published: November 2023

Learning to play an instrument at an advanced age may help to counteract or slow down age-related cognitive decline. However, studies investigating the neural underpinnings of these effects are still scarce. One way to investigate the effects of brain plasticity is using resting-state functional connectivity (FC). The current study compared the effects of learning to play the piano (PP) against participating in music listening/musical culture (MC) lessons on FC in 109 healthy older adults. Participants underwent resting-state functional magnetic resonance imaging at three time points: at baseline, and after 6 and 12 months of interventions. Analyses revealed piano training-specific FC changes after 12 months of training. These include FC increase between right Heschl’s gyrus (HG), and other right dorsal auditory stream regions. In addition, PP showed an increased anticorrelation between right HG and dorsal posterior cingulate cortex and FC increase between the right motor hand area and a bilateral network of predominantly motor-related brain regions, which positively correlated with fine motor dexterity improvements. We suggest to interpret those results as increased network efficiency for auditory-motor integration. The fact that functional neuroplasticity can be induced by piano training in healthy older adults opens new pathways to countervail age related decline.
Effects of low-level RF fields reveal complex pattern of magnetic input to the avian magnetic compass
Authors: Muheim Rachel , Phillips John B.
Published: November 2023

The avian magnetic compass can be disrupted by weak narrow-band and broadband radio-frequency (RF) fields in the lower MHz range. However, it is unclear whether disruption of the magnetic compass results from the elimination of the perception pattern produced by the magnetic field or from qualitative changes that make the pattern unrecognizable. We show that zebra finches trained in a 4-arm maze to orient relative to the magnetic field are disoriented when tested in the presence of low-level (~ 10 nT) Larmor-frequency RF fields. However, they are able to orient when tested in such RF fields if trained under this condition, indicating that the RF field alters, but does not eliminate, the magnetic input. Larmor-frequency RF fields of higher intensities, with or without harmonics, dramatically alter the magnetic compass response. In contrast, exposure to broadband RF fields in training, in testing, or in both training and testing eliminates magnetic compass information. These findings demonstrate that low-level RF fields at intensities found in many laboratory and field experiments may have very different effects on the perception of the magnetic field in birds, depending on the type and intensity of the RF field, and the birds’ familiarity with the RF-generated pattern.
Neural responses to acute stress predict chronic stress perception in daily life over 13 months
Authors: Giglberger Marina , Peter Hannah L. , Henze Gina-Isabelle , Kraus Elisabeth , Bärtl Christoph , Konzok Julian , Kreuzpointner Ludwig , Kirsch Peter , Kudielka Brigitte M. , Wüst Stefan
Published: November 2023

The importance of amygdala, hippocampus, and medial prefrontal cortex (mPFC) for the integration of neural, endocrine, and affective stress processing was shown in healthy participants and patients with stress-related disorders. The present manuscript which reports on one study-arm of the LawSTRESS project, aimed at investigating the predictive value of acute stress responses in these regions for biopsychological consequences of chronic stress in daily life. The LawSTRESS project examined law students either in preparation for their first state examination (stress group [SG]) or in the mid-phase of their study program (control group [CG]) over 13 months. Ambulatory assessments comprising perceived stress measurements and the cortisol awakening response (CAR) were administered on six sampling points (t1 = − 1 year, t2 = − 3 months, t3 = − 1 week, t4 = exam, t5 =  + 1 week, t6 =  + 1 month). In a subsample of 124 participants (SG: 61; CG: 63), ScanSTRESS was applied at baseline. In the SG but not in the CG, amygdala, hippocampus, and (post-hoc analyzed) right mPFC activation changes during ScanSTRESS were significantly associated with the trajectory of perceived stress but not with the CAR. Consistent with our finding in the total LawSTRESS sample, a significant increase in perceived stress and a blunted CAR over time could be detected in the SG only. Our findings suggest that more pronounced activation decreases of amygdala, hippocampus, and mPFC in response to acute psychosocial stress at baseline were related to a more pronounced increase of stress in daily life over the following year.
Fe3O4@void@C-Schiff-base/Pd yolk-shell nanostructures as an effective and reusable nanocatalyst for Suzuki coupling reaction
Authors: Barzkar Aliyeh , Salimi Beni Alireza , Parang Shahab , Salahshour Farhang
Published: November 2023

This article describes the synthesis of a novel Yolk-Shell structured Magnetic Yolk-Shell Nanomaterials Modified by Functionalized Carbon Shell with Schiff/Palladium Bases (Fe3O4@void@C-Schiff-base/Pd). The designed Fe3O4@void@C-Schiff-base/Pd catalyst was characterized using several techniques such as Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometry (VSM), scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDX), thermal gravimetric analysis (TGA), powder X-ray diffraction (PXRD) and Inductively coupled plasma (ICP). The Fe3O4@void@C-Schiff-base/Pd was used as powerful catalyst for preparation Suzuki reaction in short reaction times and high yield in H2O at 60 °C and presence of potassium carbonate base. This nanocatalyst was magnetically recovered and reused several times with keeping its efficiency.
Mycoparasitism related targets of Tmk1 indicate stimulating regulatory functions of this MAP kinase in Trichoderma atroviride
Authors: Atanasova Lea , Marchetti-Deschmann Martina , Nemes Albert , Bruckner Bianca , Rehulka Pavel , Stralis-Pavese Nancy , Łabaj Paweł P. , Kreil David P. , Zeilinger Susanne
Published: November 2023

Mycoparasitism is a key feature of Trichoderma (Hypocreales, Ascomycota) biocontrol agents. Recent studies of intracellular signal transduction pathways of the potent mycoparasite Trichoderma atroviride revealed the involvement of Tmk1, a mitogen-activated protein kinase (MAPK), in triggering the mycoparasitic response. We previously showed that mutants missing Tmk1 exhibit reduced mycoparasitic activity against several plant pathogenic fungi. In this study, we identified the most robustly regulated targets that were governed by Tmk1 during mycoparasitism using transcriptome and proteome profiling. Tmk1 mainly exerts a stimulating function for T. atroviride during its mycoparasitic interaction with the fungal plant pathogen Rhizoctonia solani, as reflected by 89% of strongly differently responding genes in the ∆tmk1 mutant compared to the wild type. Specifically, 54% of these genes showed strong downregulation in the response with a deletion of the tmk1 gene, whereas in the wild type the same genes were strongly upregulated during the interaction with the fungal host. These included the gene encoding the mycoparasitism-related proteinase Prb1; genes involved in signal transduction pathways such as a candidate coding for a conserved 14-3-3 protein, and a gene coding for Tmk2, the T. atroviride cell-wall integrity MAP kinase; genes encoding a specific siderophore synthetase, and multiple FAD-dependent oxidoreductases and aminotransferases. Due to the phosphorylating activity of Tmk1, different (phospho-)proteomics approaches were applied and identified proteins associated with cellular metabolism, energy production, protein synthesis and fate, and cell organization. Members of FAD- and NAD/NADP-binding-domain proteins, vesicular trafficking of molecules between cellular organelles, fungal translational, as well as protein folding apparatus were among others found to be phosphorylated by Tmk1 during mycoparasitism. Outstanding downregulation in the response of the ∆tmk1 mutant to the fungal host compared to the wild type at both the transcriptome and the proteome levels was observed for nitrilase, indicating that its defense and detoxification functions might be greatly dependent on Tmk1 during T. atroviride mycoparasitism. An intersection network analysis between the identified transcripts and proteins revealed a strong involvement of Tmk1 in molecular functions with GTPase and oxidoreductase activity. These data suggest that during T. atroviride mycoparasitism this MAPK mainly governs processes regulating cell responses to extracellular signals and those involved in reactive oxygen stress.
Trehalose metabolism coordinates transcriptional regulatory control and metabolic requirements to trigger the onset of cassava storage root initiation
Authors: Sukko Nattavat , Kalapanulak Saowalak , Saithong Treenut
Published: November 2023

Cassava storage roots (SR) are an important source of food energy and raw material for a wide range of applications. Understanding SR initiation and the associated regulation is critical to boosting tuber yield in cassava. Decades of transcriptome studies have identified key regulators relevant to SR formation, transcriptional regulation and sugar metabolism. However, there remain uncertainties over the roles of the regulators in modulating the onset of SR development owing to the limitation of the widely applied differential gene expression analysis. Here, we aimed to investigate the regulation underlying the transition from fibrous (FR) to SR based on Dynamic Network Biomarker (DNB) analysis. Gene expression analysis during cassava root initiation showed the transition period to SR happened in FR during 8 weeks after planting (FR8). Ninety-nine DNB genes associated with SR initiation and development were identified. Interestingly, the role of trehalose metabolism, especially trehalase1 (TRE1), in modulating metabolites abundance and coordinating regulatory signaling and carbon substrate availability via the connection of transcriptional regulation and sugar metabolism was highlighted. The results agree with the associated DNB characters of TRE1 reported in other transcriptome studies of cassava SR initiation and Attre1 loss of function in literature. The findings help fill the knowledge gap regarding the regulation underlying cassava SR initiation.
Bee gomogenat enhances the healing process of diabetic wounds by orchestrating the connexin-pannexin gap junction proteins in streptozotocin-induced diabetic mice
Authors: Sayed Leila H. , Badr Gamal , Omar Hossam El-Din M. , Elghaffar Sary Khaleel Abd , Sayed Aml
Published: November 2023

Delay in wound healing remains one of diabetes's worse side effects, which increases mortality. The proposed study sought to scrutinize the implications of bee gomogenat (BG) on diabetic's wound closure in a streptozotocin-(STZ)-enhanced type-1 diabetes model’s rodents. We used 3 different mice groups: group 1 non-diabetic rodents "serving as control", group 2 diabetic rodents, and group3 BG-treated diabetic rodents. We noticed that diabetic rodents experience a delayed wound closure, which emerged as a significant (*P < 0.05) decline in the deposition of collagen as compared to control non-diabetic animals. We noticed that diabetic rodents have a delayed wound closure characterized by a significant (*P < 0.05) decrease in the CD31 expression (indicator for wound angiogenesis and neovascularization) and an apparent elevation in the expression of such markers of inflammation as MCP-1 and HSP-70 as compared to control animals. Moreover, diabetic animals displayed a significant (*P < 0.05) increase in the expression of gap junction proteins Cx43 and a significant decrease in the expression of Panx3 in the wounded skin tissues when compared to the controls. Intriguingly, topical application with BG on the diabetic wounded skin tissues contributes to a significant (#P < 0.05) enhancing in the collagen deposition, up-regulating the level of CD31 expression and a significant (#P < 0.05) down-regulation in the MCP-1 and HSP-70 expressions as compared to diabetic non-treated animals. The expression's levels of Cx43 and Panx3 were significantly (#P < 0.05) retrieved in diabetic rodents after BG treatment. Taken together, our findings showed for the first time that BG promotes the recovering process and accelerated the closure of diabetic related wounds.
Kisspeptin-10 increases collagen content in the myocardium by focal adhesion kinase activity
Authors: Radwańska Paulina , Gałdyszyńska Małgorzata , Piera Lucyna , Drobnik Jacek
Published: November 2023

The aim of the study was to evaluate the role of kisspeptin-10 (KiSS-10) in the regulation of collagen content in cardiac fibroblasts. An attempt was also made to describe the mechanism of the effect of KiSS-10 on collagen metabolism. The studies indicate that kisspeptin-10 significantly increases the content of intracellular collagen in the myocardium. KiSS-10 also elevates the level of phosphorylated focal adhesion kinase (FAK) in human cardiac fibroblasts. The inhibition of FAK negates the stimulatory effect of KiSS-10 on collagen deposition in vitro. These changes correlate with an increase in the level of propeptides of procollagen type I (PICP) and III (PIIICP) in fibroblast culture medium and mouse PIIICP in serum. Moreover, this hormone inhibits the release of metalloproteinases (MMP-1,-2,-9) and elevates the secretion of their tissue inhibitors (TIMP-1,-2,-4). KiSS-10 also enhances the expression of α1 chains of procollagen type I and III in vitro. Thus, KiSS-10 is involved in the regulation of collagen metabolism and cardiac fibrosis. Augmentation of collagen deposition by KiSS-10 is dependent on the protein synthesis elevation, inhibition of MMPs activity (increase of TIMPs release) or decrease of MMPs concentration. The profibrotic activity of KiSS-10 is mediated by FAK and is not dependent on TGF-β1.
Investigation of interaction effects of biochars and silicon on growth and chemical composition of Zea mays L. in a Ni-polluted calcareous soil
Authors: Boostani Hamid Reza , Hardie Ailsa G. , Najafi-Ghiri Mahdi , Bijanzadeh Ehsan
Published: November 2023

Biochars are cost effective, carbonaceous amendments that can immobilize potentially toxic elements (PTEs) in soils. Application of silicon (Si) has been shown to mitigate the effect of soil PTEs on plants. Studies on the interaction effects of Si and biochars in PTE-contaminated soils are limited. Thus, the aim of this study was to investigate the interaction effects of biochars, from sheep manure (SMB) and rice husk (RHB) produced at 300 and 500 °C, and 2 levels of Si (as sodium (Na) metasilicate), on growth and chemical composition of corn (Zea mays) in a nickel (Ni)-polluted calcareous soil. The combined application of Si and biochars significantly reduced soil available Ni (17–32%) and the corn shoot Ni concentrations (29–58%), associated with soil pH increase (r = 0.56–0.60, P < 0.01). Application of SMB resulted in greater soil pH increases compared to RHB, and increased soil electrical conductivity (EC) to saline levels, attributed to its higher ash content. Increasing Si application levels also increased soil pH and EC values. Application of all the biochars resulted in significant biomass increases, with RHB having the most positive effect. Despite the positive effect on soil Ni immobilization, the combined application of Si and biochars generally resulted in a decrease in corn shoot biomass yields compared to biochars alone. The biomass decrease was attributed to the significantly higher soil sodicity and pH in the combined treatments which resulted in suppression of macro and micronutrient uptake by the corn. Although the combination of biochar and Na metasilicate was effective at immobilizing soil Ni, future studies should rather employ other essential basic cation metasilicates.
Freezing tolerance and tolerance to de-acclimation of European accessions of winter and facultative barley
Authors: Wójcik-Jagła Magdalena , Rapacz Marcin
Published: November 2023

Due to global warming, winter hardiness may seem to become less important for plant survival and yield. However, this is a superficial assumption, as probably only the most important factors locally affecting plant overwintering will change. For example, the frequency, degree, and length of extreme winter warming events may increase, leading to de-acclimation of plants. This study aimed to investigate existing variability in de-acclimation tolerance in Polish winter barley breeding materials and European winter and facultative barley cultivars, and to identify accessions with the highest and the lowest tolerance to de-acclimation by means of visual estimation of regrowth after freezing, measurements of electrolyte leakage and chlorophyll fluorescence, and LT50 assessment. The results of this study showed that freezing tolerance and tolerance to de-acclimation are independent traits, and even highly freezing tolerant plants can be susceptible to de-acclimation. Our results highlight the role of photosynthetic apparatus in de-acclimation, proving that chlorophyll fluorescence parameters, especially ET0/CS, can be useful indicators of tolerance to de-acclimation. This study also confirmed that although the mechanisms of response to de-acclimation seem to be common for susceptible barley accessions, the mechanisms of tolerance are different, and may be related to the accession’s origin.
Population-level effectiveness of alternative approaches to preventing mental disorders in adolescents and young adults
Authors: Skinner Adam , Occhipinti Jo-An , Song Yun Ju Christine , Hickie Ian B.
Published: November 2023

Preventive interventions that are effective in reducing the incidence of mental disorders in adolescence and early adulthood may impact substantially on lifetime economic, educational, and health outcomes; however, relatively few studies have examined the capacity of alternative approaches to preventing youth mental disorders (specifically, universal, selective, and indicated prevention) to reduce disorder incidence at a population level. Using a dynamic model of the onset of non-specific, relatively mild symptoms and progression to more severe disease, we show that: (1) indicated preventive interventions, targeting adolescents and young adults experiencing subthreshold symptoms, may often be more effective in reducing mental disorder prevalence than universal interventions delivered to the general population (contrary to the widely accepted view that a ‘high risk’ prevention strategy, focussing on those individuals with the greatest risk of developing a disorder, will generally be less effective than a whole-population strategy); and (2) the ability of selective preventive interventions (targeting vulnerable, asymptomatic youth) to alter the prevalence of mental disorders is severely restricted by an inverse relationship between the prevalence of significant risk factors for mental illness and the relative risk of developing symptoms.
Comparison of the noise produced by the polymer and bronze P1566 propellers in the cavitation tunnel
Authors: Szymak Piotr , Grządziela Andrzej , Naus Krzysztof
Published: November 2023

The paper presents the selected results of the international project called Nextprop, carried out in the framework of the European Defence Agency, which main goal was to examine elastic polymer propellers. The article includes the results of the comparative analysis in terms of the noise produced by two propellers: (1) the classical one made from Nickel Aluminium Bronze (NAB) and (2) the novel elastic counterpart manufactured from polyamide. The measurements were taken in the CTO cavitation tunnel in Gdańsk, Poland. The obtained results allow the following highlights to be formulated: the novel flexible propellers seem to be a promising solution for the new ships, especially in terms of energetic efficiency and produced noise, i.e. lower sound pressure level has been obtained for the new polymer propeller and larger advance speed for the same rotational speeds has been received for the new propeller compared to the classical metal counterpart. At the beginning, the introduction with the results of state-of-the-art analysis is presented. Then, the description of the measurement stand and examined propellers with seizing conditions is included. Next, the obtained results are illustrated and discussed. At the end, the conclusions with the draft of the future research are presented.
Heavy metal toxicity arising from the industrial effluents repercussions on oxidative stress, liver enzymes and antioxidant activity in brain homogenates of Oreochromis niloticus
Authors: Ishaq Sarwat , Jabeen Ghazala , Arshad Mateen , Kanwal Zakia , Un Nisa Fakhar , Zahra Rida , Shafiq Zunaira , Ali Hassan , Samreen Khush Bakht , Manzoor Farkhanda
Published: November 2023

Industrial effluents reaching to the aquatic ecosystem is one of the major causes of environmental pollution and exposure to industrial effluents containing harmful substances may be a serious threat to human health. Therefore, the present study aimed to determine the sub-lethal (1/5th of predetermined LC50) impact of industrial effluents from Sundar Industrial Estate on Oreochromis niloticus with proper negative control. The physicochemical analysis of industrial effluents showed enormous loads of inorganic pollutants and exhibited high mean levels of heavy metals, Mn, Fe, Pb, Ni, Cr, Hg, As, Zn and Fe with statistically significant differences at p < 0.05. Highest level of Mn and Fe was detected in effluent’s samples as 147.36 ± 80.91 mg/L and 90.52 ± 32.08 mg/L, respectively. Exposure led to increase in serum biochemical parameters alanine aminotransferase + 25%, aspartate aminotransferase + 20% and alkaline phosphatase + 7% over control although superoxide dismutase, catalase, glutathione peroxidase and reduced glutathione significantly increased as 3.42, 2.44, 4.8 and 8 folds, respectively in metabolically active tissue brain which indicated stress caused by industrial effluents. The results concluded that industrial effluent has potent oxidative stress inducers on one hand whereas histoarchitectural and physiological toxicity causing contaminants on the other. This condition may adversely affect the health of aquatic organisms, the fish and ultimately the human beings.
Comparison of detection methods for carbonation depth of concrete
Authors: Li Bei , Tian Ye , Zhang Guoyi , Liu Yu , Feng Huiping , Jin Nanguo , Jin Xianyu , Wu Hongxiao , Shao Yinzhe , Yan Dongming , Zhou Zheng , Wang Shenshan , Zhang Zhiqiang , Chen Jin , Chen Xiaodong , Lu Yunjun , Li Xinyi , Wang Jiaxi
Published: November 2023

This paper presents comprehensive research of the advantages and applicability of various concrete carbonation detection methods. Employing a combination of Phenolphthalein indicator (PI), Thermogravimetric analysis (TGA), X-ray phase analysis (XRD), Fourier transform infrared spectroscopy (FTIR), and Quantitative calcium carbonate analysis (CA), a detailed comparison to determine the carbonation depth in the partial carbonation zone of concrete specimens is conducted. Among the quantitative analysis methods, CA measures CaCO3 content based on chemical reactions, while TGA obtains the concentration distribution of Ca(OH)2 and CaCO3. Among qualitative analysis methods, XRD tested the intensity distribution of Ca(OH)2 and CaCO3, while FTIR traced the characteristic peaks of C-O functional groups in a specific spectral range to determine the depth of carbonation of concrete. Results indicate that the depth of carbonation values measured by CA, TGA, XRDA, and FTIR are 2–3 times higher than those measured by PI. This research may provide valuable insights for the design of carbonation detection in concrete.
The effects of CPET-guided cardiac rehabilitation on exercise tolerance in older persons with CHD after PCI
Authors: Shen Tao , Wang Yuwei , Ren Chuan , Song Yanxin , Gao Wei , Liu Fen , Li Gang , Wei Zhimin , Wang Peng , Zhao Wei
Published: November 2023

Prescribing appropriate exercise is an important means to improve the safety and efficacy of cardiac rehabilitation. Improper exercise may induce an increased cardiovascular risk in older persons with coronary heart disease. Cardiopulmonary exercise testing (CPET)-guided cardiac rehabilitation could be helpful for providing clinical evidence for cardiac rehabilitation therapy in older persons after percutaneous coronary intervention (PCI). We retrospectively included older persons who underwent PCI and cardiac rehabilitation based on CPET at the Cardiac Rehabilitation Center of Peking University Third Hospital from January 2014 to December 2019. Patients’ baseline and follow-up clinical data were collected. A total of 403 older persons after PCI were included in the study. The mean age was 80.5 ± 4.3. The mean follow-up time was 12 ± 2 months. During the follow-up period, no significant exercise-related adverse events occurred, and the peak oxygen uptake (VO2peak) increased compared with baseline (15.5 ± 3.8 ml/min/kg vs. 17.3 ± 4.1 ml/min/kg). Among the 90 patients (22.2%) without exercise habits at baseline who started regular exercise during follow-up, the improvement in VO2peak was most significant, at 3.2 ± 0.4 ml/min/kg. Cardiac rehabilitation based on CPET improved exercise habits and exercise tolerance in older persons with coronary heart disease after PCI.
Seasonally distinct contributions of greenhouse gases and anthropogenic aerosols to historical changes in Arctic moisture budget
Authors: Choi Hwa-Jin , Min Seung-Ki , Yeh Sang-Wook , An Soon-Il , Kim Baek-Min
Published: November 2023

Arctic hydrological cycle has important global implications through modifying deep ocean circulation via fresh water fluxes. However, attribution of the observed changes in Arctic moisture budget remains challenging due to the lack of reliable observations. Here, as a first step, past changes in hydrological cycle over the Arctic were evaluated using CMIP6 historical simulations. To examine possible influences of individual external forcings, CMIP6 multi-model simulations performed under natural-plus-anthropogenic (ALL), greenhouse gas (GHG), natural (NAT), and aerosol (AER) forcings were compared. Results indicate that Arctic precipitation and evaporation increase in ALL and GHG but decrease in AER. In ALL and GHG, Arctic precipitation increases in summer mainly due to enhanced poleward moisture transport whereas Arctic moistening during winter is affected more by increased surface evaporation over sea-ice retreat areas. In AER, Arctic precipitation tends to decrease due to reduced evaporation over sea-ice advance areas during cold months. Poleward meridional moisture flux (MMF) across 70°N is the strongest in summer due to the highest moisture. GHG has stronger MMF than other forcing simulations due to larger increase in moisture in line with stronger warming. The MMF response is found to be largely determined by variations in transient eddies with distinct seasonal and regional contributions.
Implications of different cell death patterns for prognosis and immunity in lung adenocarcinoma
Authors: Zhou Yang , Gao Weitong , Xu Yu , Wang Jiale , Wang Xueying , Shan Liying , Du Lijuan , Sun Qingyu , Li Hongyan , Liu Fang
Published: November 2023

In recent years, lung adenocarcinoma (LUAD) has become a focus of attention due to its low response to treatment, poor prognosis, and lack of reliable indicators to predict the progression or therapeutic effect of LUAD. Different cell death patterns play a crucial role in tumor development and are promising for predicting LUAD prognosis. From the TCGA and GEO databases, we obtained bulk transcriptomes, single-cell transcriptomes, and clinical information. Genes in 15 types of cell death were analyzed for cell death index (CDI) signature establishment. The CDI signature using necroptosis + immunologic cell death-related genes was established in the TCGA cohort with the 1-, 2-, 3-, 4- and 5-year AUC values were 0.772, 0.736, 0.723, 0.795, and 0.743, respectively. The prognosis was significantly better in the low CDI group than in the high CDI group. We also investigated the relationship between the CDI signature and clinical variables, published prognosis biomarkers, immune cell infiltration, functional enrichment pathways, and immunity biomarkers. In vitro assay showed that HNRNPF and FGF2 promoted lung cancer cell proliferation and migration and were also involved in cell death. Therefore, as a robust prognosis biomarker, CDI signatures can screen for patients who might benefit from immunotherapy and improve diagnostic accuracy and LUAD patient outcomes.
Pathway selection in the self-assembly of Rh4L4 coordination squares under kinetic control
Authors: Okazawa Atsushi , Sanada Naoki , Takahashi Satoshi , Sato Hirofumi , Hiraoka Shuichi
Published: November 2023

Pathway selection principles in reversible reaction networks such as molecular self-assembly have not been established yet, because achieving kinetic control in reversible reaction networks is more complicated than in irreversible ones. In this study, we discovered that coordination squares consisting of cis-protected dinuclear rhodium(II) corner complexes and linear ditopic ligands are assembled under kinetic control, perfectly preventing the corresponding triangles, by modulating their energy landscapes with a weak monotopic carboxylate ligand (2,6-dichlorobenzoate: dcb–) as the leaving ligand. Experimental and numerical approaches revealed the self-assembly pathway where the cyclization step to form the triangular complex is blocked by dcb–. It was also found that one of the molecular squares assembled into a dimeric structure owing to the solvophobic effect, which was characterized by nuclear magnetic resonance spectroscopy and single-crystal X-ray analysis.
Dynamic social interactions and keystone species shape the diversity and stability of mixed-species biofilms – an example from dairy isolates
Authors: Sadiq Faizan Ahmed , De Reu Koen , Steenackers Hans , Van de Walle Ann , Burmølle Mette , Heyndrickx Marc
Published: November 2023

Identifying interspecies interactions in mixed-species biofilms is a key challenge in microbial ecology and is of paramount importance given that interactions govern community functionality and stability. We previously reported a bacterial four-species biofilm model comprising Stenotrophomonas rhizophila, Bacillus licheniformis, Microbacterium lacticum, and Calidifontibacter indicus that were isolated from the surface of a dairy pasteuriser after cleaning and disinfection. These bacteria produced 3.13-fold more biofilm mass compared to the sum of biofilm masses in monoculture. The present study confirms that the observed community synergy results from dynamic social interactions, encompassing commensalism, exploitation, and amensalism. M. lacticum appears to be the keystone species as it increased the growth of all other species that led to the synergy in biofilm mass. Interactions among the other three species (in the absence of M. lacticum) also contributed towards the synergy in biofilm mass. Biofilm inducing effects of bacterial cell-free-supernatants were observed for some combinations, revealing the nature of the observed synergy, and addition of additional species to dual-species combinations confirmed the presence of higher-order interactions within the biofilm community. Our findings provide understanding of bacterial interactions in biofilms which can be used as an interaction–mediated approach for cultivating, engineering, and designing synthetic bacterial communities.
Ultramicro and ultrasensitive detection of lipopolysaccharides based on triple-signal amplification via ultrafast ATRP and an ultramicroelectrode
Authors: Jiang Shipeng , Sun Mingyang , Meng Peiran , Zhang Xiaoyu , Sun Yue
Published: November 2023

An ultrasensitive electrochemical sensor requiring 5 μL solution was developed for lipopolysaccharide detection via triple-signal amplification based on UATRP.
Facile synthesis of Ag lattice doped mesoporous In2O3 nanocubes for high performance ethanol sensing
Authors: Liu Xinyu , Jia Cuiping , liu Xin , Luo Jiabing , Zhou Yan , Li Wenle , Wang Shutao , Zhang Jun
Published: November 2023

Ag lattice doped In2O3 with a mesoporous structure was synthesized successfully. The 7.0 mol% Ag-doped In2O3 sensor displayed a response of 420 towards 100 ppm ethanol at 140 °C, which was 19 times higher than that of the pure In2O3 gas sensor.
Sample transformation in online separations: how chemical conversion advances analytical technology
Authors: van der Zon Annika A. M. , Verduin Joshka , van den Hurk Rick S. , Gargano Andrea F. G. , Pirok Bob W. J.
Published: November 2023

Sample transformation can be used to provide insights into the properties of complex samples.
Ferrocene: an exotic building block for supramolecular assemblies
Authors: Guchhait Chandrakanta , Suriyaa Vembanan , Sahu Nihar , Sarkar Sovik Dey , Adhikari Bimalendu
Published: November 2023

Beyond organometallics, ferrocene supports a range of noncovalent interactions for the development of host-guest assemblies, molecular receptors, supramolecular polymers, gels, metal-organic, out-of-equilibrium and metal nanoparticle assemblies.
Large vibrationally induced parity violation effects in CHDBrI+
Authors: Eduardus  , Shagam Yuval , Landau Arie , Faraji Shirin , Schwerdtfeger Peter , Borschevsky Anastasia , Pašteka Lukáš F.
Published: November 2023

The isotopically chiral molecular ion CHDBrI+ is identified as an exceptionally promising candidate for the detection of parity violation in vibrational transitions.
Decarboxylative halogenation of indoles by vanadium haloperoxidases
Authors: Harstad Lauren J. , Wells Clare E. , Lee Hyung Ji , Ramos Lauren P. T. , Sharma Manik , Pascoe Cameron A. , Biegasiewicz Kyle F.
Published: November 2023

Biocatalytic decarboxylative halogenation of 3-carboxyindoles is enabled by vanadium haloperoxidases with halogenation generality.
Lead-oriented synthesis of epigenetic relevant scaffolds
Authors: Maujean Timothé , Kannaboina Prakash , Green Adam I. , Burslem George M.
Published: November 2023

We report a simple and rational method to rank lead-likeness of molecules using continuous evaluation functions.
Synthesis of medium-sized heterocycles from oxetanes based on an allylic amination/ring-opening strategy
Authors: Li Jixing , Fang Ming , Liao Maoyan , Xie Hongling , Dong Xiu-Qin , Han Zhengyu , Sun Jianwei , Huang Hai
Published: November 2023

In this study, a tandem strategy has been developed for the synthesis of medium-sized heterocycles from oxetanes through the allylic amination/ring-opening of oxetanes.
Isolation of the elusive [Ru(bipy)3]+: a key intermediate in photoredox catalysis
Authors: Horsewill Samuel J. , Cao Chengyang , Dabney Noah , Yang Eric S. , Faulkner Stephen , Scott Daniel J.
Published: November 2023

[Ru(bipy)3]+ is a key intermediate in the chemistry of the ubiquitous [Ru(bipy)3]2+, including in recent photoredox applications. Isolation helps to illuminate the monocation’s structure and potential roles in catalytic reactivity.
Isolation of an organometallic yttrium bismuth cluster and elucidation of its electronic structure
Authors: Pugliese Elizabeth R. , Benner Florian , Demir Selvan
Published: November 2023

A rare molecular cluster compound of bismuth and yttrium, [K(THF)4][Cp*2Y2Bi6], featuring a bridging cyclohexane-like Bi66− chair, was isolated and characterised via single-crystal X-ray diffraction analysis, UV-Vis spectroscopy and DFT calculations.
Molecular elastic crystals exhibiting slow magnetic relaxations
Authors: Kato Hinako , Horii Yoji , Noguchi Mariko , Fujimori Hiroki , Kajiwara Takashi
Published: November 2023

Elastic crystals exhibiting slow magnetic relaxation behaviour were constructed by combining alkyl-substituted porphyrins and copper(ii) ions.
Copper-catalyzed atroposelective formal [4+1] annulation of 1,2-diketones with vinyl cations
Authors: Wang Ze-Shu , Xu Hao-Jin , Chen Yang-Bo , Ye Long-Wu , Zhou Bo , Qian Peng-Cheng
Published: November 2023

A copper-catalyzed atroposelective formal [4+1] annulation of 1,2-diketones with diynes has been developed, affording axially chiral arylpyrroles bearing 1,3-dioxole moieties with high enantioselectivities under mild conditions.
Dealloying-derived nanoporous Sn-doped copper with prior selectivity toward formate for CO2 electrochemical reduction
Authors: Yuan Hefeng , Kong Bohao , Liu Zhehao , Cui Li , Wang Xiaoguang
Published: November 2023

Dealloying-derived nanoporous Sn-doped copper possesses prior selectivity toward formate in the CO2 electrochemical reduction process.
Artificial nucleotide codons for enzymatic DNA synthesis
Authors: Sabat Nazarii , Stämpfli Andreas , Flamme Marie , Hanlon Steven , Bisagni Serena , Sladojevich Filippo , Püntener Kurt , Hollenstein Marcel
Published: November 2023

Synthesis three-by-three: trinucleotide triphosphates can be used for enzymatic DNA synthesis provided their backbone is stabilized with chemical modifications.
Structure–activity strategies for mechanically responsive fluorescent materials: a molecular perspective
Authors: Fei Guiqiang , Li Shaoqi , Liu Yuxia , Carney Jared B. , Chen Tao , Li Yulin , Gao Xiaoyong , Chen Ji , Chen Pu , Yue Yanfeng , Bao Kai , Tang Bo , Chen Guang
Published: November 2023

Mechanical response luminescence (MRL) describes the photophysical properties triggered by mechanical stimulation.
Early warning technology for common characteristic resistances of lithium-ion batteries with thermal runaway
Authors: Yang Zhigao , Gu Zhengjian , Tao Qianyi , Bao Jun , Li Huanhuan , Wang Shengping
Published: November 2023

Combining for the resistance system and the temperature system of lithium-ion batteries, over 25 min in advance for the earlier prediction of thermal runaway (TR) and over 3 min for the preparation of fighting with unavoidable TR are realized.
A metal organic framework-derived octahedral Cu1.95S@CoS2 for secondary batteries displaying long cycle life and stable temperature tolerance
Authors: Han Tianli , Bai Haiyuan , Xu Jing , Zhu Yajun , Lin Xirong , Liu Jinyun
Published: November 2023

A metal organic framework (MOF)-derived octahedral Cu1.95S@CoS2 composite is developed as a high-performance Al-ion battery cathode, which displays high and stable capacities at room temperature and −10 °C.
Solvent effect in the chemical design of coordination polymers of various topologies with Co2+ and Ni2+ ions and 2-furoate anions
Authors: Uvarova Marina A. , Lutsenko Irina A. , Babeshkin Konstantin A. , Sokolov Andrey V. , Alexandrov Eugeny V. , Efimov Nikolay N. , Shmelev Maxim A. , Khoroshilov Andrey V. , Eremenko Igor L. , Kiskin Mikhail A.
Published: November 2023

Self-assembly of coordination polymers of different dimensions depending on the solvent.
Blue shifts in helium-surface bound-state resonances and quantum effects in cosine-law scattering
Authors: Staszewski Luke , Avidor Nadav
Published: November 2023

Simulations of elastic helium scattering from LiF like surface reveal blue shifts of bound state energies, induced by surface defects, which eventually lead to difuse cosince scattering.
Styrylpyrimidine chromophores with bulky electron-donating substituents: experimental and theoretical investigation
Authors: Hodée Maxime , Massue Julien , Achelle Sylvain , Fihey Arnaud , Tondelier Denis , Ulrich Gilles , Guen Françoise Robin-le , Katan Claudine
Published: November 2023

The photophysical properties of styrylpyrimidines with bulky electron-donating substituents are studied. The absence of thermally activated delayed fluorescence is rationalized thanks to experimental and theoretical investigations.
Phase diagrams and superconductivity of ternary Ca–Al–H compounds under high pressure
Authors: Xu Ming , Duan Defang , Du Mingyang , Zhao Wendi , An Decheng , Song Hao , Cui Tian
Published: November 2023

The search for high-temperature superconductors in hydrides under high pressure has always been a research hotspot.
Blind prediction of toluene/water partition coefficients using COSMO-RS: results from the SAMPL9 challenge
Authors: Nevolianis Thomas , Ahmed Raja A. , Hellweg Arnim , Diedenhofen Michael , Leonhard Kai
Published: November 2023

Accurately predicting partition coefficients log P is crucial for reducing costs and accelerating drug design as it provides valuable information about the bioavailability, pharmacokinetics, and toxicity of different drug candidates.
van der Waals induced ice growth on partially melted ice nuclei in mist and fog
Authors: Boström M. , Li Y. , Brevik I. , Persson C. , Carretero-Palacios S. , Malyi O. I.
Published: November 2023

A Casimir–Lifshitz (van der Waals) energy-induced mechanism is explored and applied to ice formation in mist and fog.
A white light emitting single halochromic hydrazine bridged bis(3-pyrrolyl BODIPY) fluorophore
Authors: Behera Kanhu Charan , Ravikanth Mangalampalli
Published: November 2023

A single halochromic hydrazine bridged bis(3-pyrrolyl BODIPY) fluorophore was synthesized and the white light emission of the fluorophore in its protonated form was demonstrated.
High-performance and self-powered photodetectors from an S-scheme Cs2SnI2Cl2/Cs2TiI6 heterojunction: a DFT+NAMD study
Authors: Li Dongxiang , Li Ruiqin
Published: November 2023

The recently reported two-dimensional (2D) Ruddlesden–Popper perovskite materials exhibit a plethora of advantages, making them an ideal candidate for constructing high-performance photodetectors.
Carbon-doped boron nitride nanosheets as an efficient metal-free catalyst for the selective oxidation of H2S
Authors: Lei Ganchang , Qi Sihui , Li Haiyan , Xue Yinjiang , Shen Lijuan , Zheng Xiaohai , Wang Shiping , Cao Yanning , Zhan Yingying
Published: November 2023

The as-designed carbon-doped BN with an ultrathin layer structure shows outstanding H2S elimination and high S yield.
A multisite dynamic synergistic oxygen evolution reaction mechanism of Fe-doped NiOOH: a first-principles study
Authors: Chen Hongpeng , Xie Haonan , Li Bing , Pang Jinshuo , Shi Rongrong , Yang Chen , Zhao Naiqin , He Chunnian , Chen Biao , Liu Enzuo
Published: November 2023

The synergistic mechanism among Ni–O–Fe in Fe-doped NiOOH is discovered which gives a new perspective on the synergistic effects among different compositions in metal compounds during the OER process.
Blocking recombination centers by controlling the charge density of a sulfur vacancy in antimony trisulfide
Authors: Han Xiao , Zhao Qi , Yan Xiaodan , Meng Ting , He Jinlu
Published: November 2023

Decreasing the charge density of trap states via electron acceptor and hole injection can eliminate the charge recombination centers and prolong the carrier lifetimes.
2-Pyridonates: a versatile ligand platform in 3d transition metal coordination chemistry and catalysis
Authors: Fedulin Andrey , Jacobi von Wangelin Axel
Published: November 2023

Among the vast family of aminoalcohol ligands, 2-pyridonates take a special position. This review illustrates the intriguing properties of pyridonate ligands and their key roles in 3d transition metal catalysts from the natural role model [Fe]-hydrogenase to modern applications.
InNi3C0.5@C-derived InNi3 alloy as a coke-resistant low-temperature catalyst for selective butadiene hydrogenation
Authors: Chen Zhibing , Lv Yali , Chen Xintai , Mou Xiaoling , Li Jingwei , Yan Li , Lin Ronghe , Ding Yunjie
Published: November 2023

An InNi3C0.5-derived InNi3 alloy is discovered as a coke-resistant low-temperature catalyst for the selective hydrogenation of 1,3-butadiene, affording >90% total yield of butene at 318 K.
The influence of light on the field-induced magnetization dynamics of two Er(iii) coordination polymers with different halogen substituents
Authors: Gou Xiaoshuang , Wu Yuewei , Wang Mengmeng , Liu Ning , Lan Wenlong , Zhang Yi-Quan , Shi Wei , Cheng Peng
Published: November 2023

The influence of in situ light irradiation on the field-induced magnetization dynamic pathways of two 2D Er(iii)-quinoid coordination polymers with different halogen substituents was studied.