bluuebunny/crossref_metadata_2025 huggingface dataset:
Teaching Homeopathy in U.S. Pharmacy Schools
Authors: Khader Esra'a , Doucette William
Published: November 2024

Objectives: Pharmacists often advise patients on the use of over-the counter (OTC) medications. Such a class of medications that is growing in popularity is homeopathic products. Little is known about student pharmacists are being educated about homeopathy. The objectives of this study were to describe homeopathic topics being taught in pharmacy schools and to evaluate faculty views about pharmacists’ roles in counseling patients about homeopathic products.  
Method: A mixed method design collected information about teaching homeopathy in US pharmacy schools. Online surveys were distributed to 3,300 pharmacy practice faculty members representing all schools accredited in the US. Frequencies were calculated to describe faculty characteristics and their responses. Moreover, 18 interviews of faculty involved with teaching homeopathy were conducted to learn about homeopathy teaching and expectations about roles of pharmacists in counseling patients.
Results: Survey data were collected from 365 respondents, with 51.2% of the respondents teaching in public universities, 49.6% having PGY1 training and 35.8% being associate professors. Over half (84 of 137) of the responding schools of pharmacy reported teaching homeopathy to pharmacy students. In addition, most interviewed faculty emphasized that pharmacists should be knowledgeable and able to counsel patients effectively on homeopathic products.
Conclusion: Over half of schools of pharmacy are teaching students about homeopathy topics. Further, there was support for pharmacists being able to counsel effectively about homeopathic products.
Development, Pilot, and Evaluation of a Qualitative Documentation Tool for Pharmacists to Share High Impact Patient Intervention Stories
Authors: Middendorf Alex William , Hunt Aaron , Vanden Hull Alexa , Van Gilder Deidra , Miller Erin , Pinto Sharrel
Published: November 2024

Background: Community pharmacists are often the most accessible member of the healthcare team to many patients and play a key role in managing their chronic conditions, such as diabetes or heart disease, through expanded pharmacy services like Medication Therapy Management. Despite their accessibility, pharmacy services are often underutilized due, in part, to a lack of adequate reimbursement models for pharmacy services. There is a need for qualitative data to be collected to indicate the full impact of those services and why they are so important in a patient’s healthcare journey.
Methods: An online Patient Stories Reporting Tool (PRST) was developed to allow outpatient pharmacists to document their perspectives of select direct patient care encounters that they felt showcased their value. In a pilot test, the PSRT was distributed to pharmacists from a partnering pharmacy organization. Qualitative data was collected, assessed by project team members, and organized by intervention types. For select stories, the otherwise undocumented nuances of delivered services and their impact were considered.
Results: Forty-seven stories were reported by 17 pharmacists across 13 practice sites from August 2021 to March 2023. Three types of key interventions delivered were identified including General Patient Education (7 stories), Medication Optimization (20 stories), and Cost Reduction (20 stories). Given the nature and scope of this initial pilot, one story for each of the three most prevalent intervention types was identified as exemplifying the types of stories the tool can collect.
Conclusions: The three selected stories help to characterize the services pharmacists provide, the important nuances of pharmacist-patient interactions, and the value of sharing these stories through tools like the PSRT. Through these stories, the PSRT also begins to record the nuances of pharmacist interventions and the impact they can make in a patient’s healthcare journey. Potential applications of the tool are multivarious including leading to improvements in the perception of pharmacists’ roles on the healthcare team and justifying reimbursement models.
Incorporating Evidence-Based Teaching into Pharmacy Education: A Report on the Use of Educational Theory in the Backward Design of a Drug Information Course
Authors: Wisniewski Chris , Wisniewski Jennifer , Whitney Rachel , Jones Emily
Published: November 2024

Background: One way to incorporate evidence-based teaching into healthcare education is through backward design, a pedagogical design process that starts with creating learning outcomes, then moves to assessments, followed by content creation. This study uses backward design as a framework to present an applied experience of evidence-based teaching in the design and refinement of an introductory drug information course presented in the first year of a traditional 4-year PharmD curriculum. Case Description: In addition to backward design, evidence-based teaching methods included scaffolding, pass-fail grading standards, formative assessments, flipped classroom, and gamification. Additionally, innovative assessment techniques and teaching activities were created. The full evolution of this course, along with student performance, student perceptions, faculty workload and faculty experience, are described. Case Themes: Overall, using evidence-based methodologies led to improved organization and enhanced faculty and student satisfaction. Data showed students performed well based on both assessment and course averages. Faculty workload was substantial during the initial development of the course and was mitigated once structure and organization had been better optimized over years of revision. Impact: This report provides a model for others to incorporate evidence-based teaching methods into course design in both incremental and large-scale changes. The incorporation of these ideas takes time and work from faculty but this effort has the potential to yield improved student learning and perception. Dedication to continuous review and revision of developed educational content is encouraged. Faculty found this experience rewarding and felt that it made them better and happier educators.
Pharmaceutical Telemonitoring for Patients with Psychiatric Disorders: Implementation Description
Authors: Lima Camila , Barreto Joslene , Viana Max , Alves Izabel
Published: November 2024

Telecare has exhibited efficacy in managing various chronic clinical conditions and presents potential in the surveillance of patients with psychiatric disorders, an area necessitating further investigation. Herein, we delineate an adjunct for pharmacotherapeutic oversight of individuals with psychiatric disorders receiving care at a public mental health outpatient facility. This manuscript serves as an implementation dossier detailing the progression of a preliminary trial. The non-probabilistic sample consisted of 21 patients, monitored between January 2022 and October 2022. Predominantly, schizophrenia constituted the primary psychiatric disorder among the cohort, accounting for 61.9% of cases. Across 79 remote consultations, averaging 3.8 consultations per patient, text messages constituted 52% (41/79) of the interactions. Throughout the telemonitoring process, diligent monitoring of patients' self-reported concerns was facilitated, permitting pharmaceutical interventions encompassing health advisories (52.7%) and recommendations for therapeutic adjustments (34.4%). Consequently, telemonitoring yielded an augmented pharmaceutical support framework for psychiatric patients, thereby presenting a plausible avenue for enhancing accessibility within public healthcare institutions.
Accessibility of Diabetes Therapy Management for Patients with Visual Impairment
Authors: Nguyen Cambrey , Lim Lisa , Conard Emily , Nkemdirim Okere Arinze
Published: November 2024

Introduction: According to the Centers for Disease Control, 11.8% of adults diagnosed with diabetes have severe vision difficulty or blindness, a complication of uncontrolled diabetes. The study evaluated the accessibility features of the most commonly used injectable products for diabetes and blood glucose monitors and obtained recommendations from manufacturers regarding use of these products in patients with visual disabilities.  Additionally, accessibility of the medication guides was assessed using a checklist and screen reader. 
Methods: Selection of the most commonly prescribed insulin products, GLP-1 receptor agonist drugs, and blood glucose monitors were identified from the ClinCalc DrugStats database and ADA list. The accessibility features of these products were determined from the medication guides and verification of the information with the manufacturers were done in August 2022.  All medication guides were then assessed using a checklist and tested with a screen reader for accessibility. Descriptive statistics were used to report the data.  
Results: No injectable products or glucose monitoring systems were fully accessible and manufacturers advised to use the product with caution and/or required assistance from a caregiver or family member.  In evaluating the 14 medication guides for accessibility using the checklist, the most common issues were lack of structured headings to help with navigation, no descriptions for images, and tables did not have appropriate headers.
Conclusions: Due to the lack of accessible features on diabetes medical devices and glucose monitoring systems, healthcare professionals can seek alternatives to assist this patient population to effectively manage their therapy.
Mujeres: su emergencia de la subjetividad política en los procesos de transformación social
Authors: Amaya Olaya Martha Patricia
Published: November 2024

El presente artículo analiza la emergencia y transformación de la subjetividad política de   las mujeres que trabajan en la Fundación Sembrando Futuro con Afecto (FUSEF), de la ciudad de Neiva, (Colombia) en relación con los procesos de construcción de subjetividad política en mujeres de la comunidad.  Sus narrativas desde la autoetnografía y entrevistas conversacionales derivaron categorías de análisis como la conciencia histórica que se recobra en cada relato y que dieron cuenta de los momentos de inicio de una comunidad gestada desde la libertad pero que se opacó y se invisibilizó en lo institucionalizado, en discursos hegemónicos que transversalizan el cuerpo a través del saber-poder, de los mecanismos psíquicos. Sin embargo, la resistencia provoca nuevas configuraciones y es así como la   acción política comienza nuevamente a hacer visible el encuentro con el otro en su vulnerabilidad al punto que interpela y conmueve al hacerse cargo y dar cuenta de sí mismo. Lo que propone una revisión de la ética para la vida y el apoyo compartido. El presente artículo analiza la emergencia y transformación de la subjetividad política de   las mujeres que trabajan en la Fundación Sembrando Futuro con Afecto (FUSEF), de la ciudad de Neiva, (Colombia) en relación con los procesos de construcción de subjetividad política en mujeres de la comunidad.  Sus narrativas desde la autoetnografía y entrevistas conversacionales derivaron categorías de análisis como la conciencia histórica que se recobra en cada relato y que dieron cuenta de los momentos de inicio de una comunidad gestada desde la libertad pero que se opacó y se invisibilizó en lo institucionalizado, en discursos hegemónicos que transversalizan el cuerpo a través del saber-poder, de los mecanismos psíquicos. Sin embargo, la resistencia provoca nuevas configuraciones y es así como la   acción política comienza nuevamente a hacer visible el encuentro con el otro en su vulnerabilidad al punto que interpela y conmueve al hacerse cargo y dar cuenta de sí mismo. Lo que propone una revisión de la ética para la vida y el apoyo compartido.
Influencia de los estilos educativos parentales en la participación comunitaria
Authors: Venegas Avellaneda Belcy Liliana , Risueño Solarte María Eugenia , Rojas Arango Bibiana Patricia
Published: November 2024

Este artículo presenta los resultados de la investigación cualitativa fundamentada en la teoría Ecosistémica del Desarrollo Humano, de enfoque etnográfico,  realizada con 10 familias de un barrio de la ciudad de Popayán, desde una percepción bidireccional de padres e hijos sobre los estilos educativos parentales (democrático, autoritario, negligente e indulgente) y su influencia en la participación comunitaria a partir del estudio de dos categorías: sentido de comunidad e identidad comunitaria.  Los hallazgos develaron que el estilo educativo Autoritativo o Democrático procura una mayor tendencia a la participación comunitaria en el que los roles de ambas figuras paternas son significativos. Igualmente, se determinó que la participación comunitaria de algunos miembros de las familias, cuyos estilos parentales son el autoritario y el negligente parece estar motivada, más por circunstancias particulares de cada individuo que por la influencia familiar, mientras en el estilo indulgente no muestra interés en la participación comunitaria.
Implementasi Asesmen Autentik Berbasis Literasi Numerasi dalam Pembelajaran Ilmu Pengetahuan Alam (IPA)
Authors: Hindriana Anna Fitri , Abidin Zaenal , Setiawati Ina , Wibowo Jayaman
Published: November 2024

Pelaksanaan asesmen autentik berbasis literasi dan numerasi sangat diperlukan untuk meningkatkan kemampuan peserta didik dalam mengaplikasikan pengetahuannya dalam kehidupan nyata. Pengembangan instrumen asesmen autentik berbasis literasi numerasi memerlukan perubahan mindset baik dalam melaksanakan proses penilaian maupun dalam proses pembelajaran IPA.  Pengabdian pada masyarakat ini bertujuan untuk memberikan pemahaman dan pendampingan pengembangan asesmen autentik berbasis literasi dan numerasi. Metode yang digunakan dalam pengabdian masyarakai  ini adalah metode pelatihan dan pendampingan mengenai  pemahaman konsep dasar asesmen autentik, konsep dasar literasi numerasi,  indikator literasi numerasi  serta cara mengintegrasikan pelaksanaan asesmen autentik menggunakan indikator litersi dan numerasi baik pada ranah pengetahuan, keterampilan, maupun sikap. Hasil pelatihan menunjukkan adanya peningkatan pemahaman tentang konsep dasar asesmen autentik , pemahaman tentang konsep dasar literasi dan numerasi, implementasikan asesmen autentik berbasis literasi dan numerasi pada pembelajaran IPA dan self efficacy dalam merancang dan melaksanakan asesmen yang relevan dengan literasi dan numerasi.
Menggagas Kemandirian: Resilience Disabilitas Rungu Wicara Desa Singaparna melalui Pelatihan Kepercayaan Diri untuk Berwirausaha Roti
Authors: Rahmawati Teti , Nurfatimah Siti Nuke , Rahayu Hayinah , Hana Wulan Salma , Dzikri Reyhan Rizalul
Published: November 2024

Desa Singaparna adalah rumah bagi sejumlah penyandang disabilitas rungu wicara yang menghadapi berbagai tantangan dalam menjalani kehidupan sehari-hari. Salah satunya adalah kurangnya kepercayaan diri yang dapat menghambat kemampuan mereka untuk berinteraksi dan terisolasi secara sosial dan ekonomis, yang pada akhirnya memperparah rasa rendah diri dan ketergantungan pada keluarga atau bantuan sosial.  Kegiatan ini bertujuan untuk meningkatkan kepercayaan diri dan kemandirian penyandang disabilitas rungu wicara melalui serangkaian program pelatihan yang terstruktur, komprehensif dan dukungan berkelanjutan. Pelatihan ini melibatkan metode interaktif dan inklusif seperti diskusi, role-play, dan simulasi situasi nyata, serta mentoring dan pendampingan untuk memberikan dukungan personal. Selain itu, dibentuk kelompok dukungan sebaya untuk memfasilitasi berbagi pengalaman dan motivasi. Workshop pemberdayaan diri mengajarkan teknik-teknik praktis seperti manajemen emosi dan afirmasi positif, sementara simulasi sosial memberikan kesempatan bagi peserta untuk berlatih dalam situasi nyata. Evaluasi dan refleksi diri membantu peserta memahami kemajuan mereka dan mengidentifikasi area yang perlu diperbaiki. Pemberian apresiasi dan pengakuan di akhir program meningkatkan rasa penghargaan diri dan motivasi peserta.
Implementation of Precautionary Principles in Environmental Impact Assessment (EIA) in Indonesia
Authors: Cahyani Ferina Ardhi , Anditya Ariesta Wibisono
Published: November 2024

This article aims to find out about the implementation of the precautionary principle in environmental impact assessment (EIA). The method used in this article is a normative research method. The results obtained from this research are that in terms of environmental approval requirements in Indonesia, one of the requirements is EIA. In the process of preparing EIA, implementation, as well as monitoring and evaluation, all stages require the principle of caution in their implementation. Permits issued by the government should not cause harm to the community as the holder of the highest state power. In EIA there is an obligation to examine the opinions of people who are directly affected by an activity. This is a form of implementing the precautionary principle, but there are still weaknesses in it. EIAs that have passed the assessment must also continue to monitor, evaluate and be evaluated by the government so that the risks arising from an activity can still be monitored for solutions. In this way, the precautionary principle can be implemented from planning to implementation.
Antimicrobial activity of Zn-nanoparticles synthesized by leaf extract of Capparis spinosa
Authors: AL Zaher Razan M. , Abderrahman Salim M. , Abdulateef Safa M. , Dheeb Batol Imran , Massadeh Muhannad I. , Hussein Anmar Sael , Farhan Mohammed Sami
Published: November 2024

In the last 2 decades, nanotechnology has developed significantly. It is now easy to perform materials reduction to a nano size called nanoparticles (NPs). One significant development is the use of plant extracts containing phytochemical compounds as reducing agent. Capparis spinosa, a shrub plant, was used in the synthesis of zinc oxide and iron oxide NPs. Synthesis and characterization of ZnONPs by consumed phytochemical compounds of C.spinosa leaf extract was performed. Synthesize ZnONPs from the aqueous leaf extract and characterize them using FT-IR, DLS and STEM and investigate the antimicrobial activity of NPs using agar well diffusion and the minimum inhibitory concentration (MIC). The aqueous leaf extract of C.spinosa contain flavonoids, alkaloids, tannin, phenol and saponin. FT-IR analysis showed peaks in C spinosa extract and ZnONPs spectra where different functional groups with unique peaks for ZnONPs were detected indicating the formation of specific bonds. DLS spectroscopy revealed polydispersity index (PDI) values of 0.638 for ZnONPs and STEM images for ZnONPs showed irregular NPs with sizes ranging from 33.75 to 89.14 nm. Antimicrobial test by agar well diffusion showed an inhibition zone of ZnONPs against all test microbial genera except C. glabrata and higher effect was against P.vulgaris with diameter of inhibition zone equal to 15.5± 0.7 mm. The MIC values of ZnONPs against P.vulgaris and C.Kruesi were the same (0.25mg/ml) while S.aureus, S.pyogens and C.glabrata showed less MIC value (0.125mg/ml). In conclusion, green synthesized ZnONPs showed an antimicrobial effect on skin associated microbial which can be adopted and developed with the aim of using it as an alternative to completely chemically synthesized antibiotics.
Association between some Serum Parameters in Iraqi Women with Polycystic Ovary Syndrome and leptin receptor gene polymorphism
Authors: Mahmoud Fadaa A. , Abdul-Hassan Ismail A.
Published: November 2024

Polycystic ovarian syndrome (PCOS) is considered as a complex, heterogeneous disorder that impacts 5-10% of women at reproductive age. This study aimed to evaluate the association of leptin recepter gene polymorphism (Lys109Arg, rs1137100) and some serum parameters with PCOS in of Iraqi women. This case-control study was carried out during the period from July to October, 2022 at Infertility Care and IVF center of Kamal AL-Samaraay Hospital, Baghdad. The study included 120 Iraqi women as a sample size divided into two groups 60 PCOS patients and 60 apparently healthy control. PCOS patients were diagnosed by gynecologists according to Rotterdam criteria. The genotypes of leptin receptor gene at rs137100 SNP were determined by using HRM-PCR. The serum levels of leptin, soluble leptin receptor (sOB-R) and AMH were measured by using Elisa kits. Lipid profile parameters were measured by spin 200 full auto. LH, FSH, testosterone, estradiol, progesterone, TSH, T3 and T4 hormones were measured by cobas E411. Results revealed that BMI values were significantly increased (p≤0.01) in PCOS patients compared to controls (30.21±0.70 versus 24.28±0.617). Serum leptin and sOB-R levels were significantly (p˂0.05) higher in PCOS patients than controls (4303.28±71.55 versus 3854.84 ±213.96 pg /ml and 144.09 ±5.51 versus 122.16 ±7.64 ng/ml respectively). The frequency of AA genotypes was significantly (p˂0.05) lower in PCOS patients than in apparently healthy subjects (33.3 % versus 65.0% respectively) whereas the frequencies of AG and GG genotypes were significantly (p˂0.05) higher in PCOS patients versus controls (53.3% versus 26.6% and 13.4% versus 8.4% respectively).The A allele frequency was higher in apparently healthy subjects than in PCOS women (78.3% versus 60.0% respectively) while G allele frequency was significantly higher in PCOS patients versus controls (80.0% versus 21.7%, respectively). It was concluded that the leptin receptor polymorphism (rs1137100) is strongly linked to an increased risk of developing PCOS. Further, those with the A allele are less likely to develop PCOS.
Biosynthesis of Selenium and Copper Oxide Nanoparticles using Probiotic Bacteria against Food Spoilage Microorganisms
Authors: Abdullah Emad Abdulsattar , Jafar Nehan Bahaaldden , Badawi Sumyia Khalaf
Published: November 2024

The study’s aim is to synthesize selenium (SeNPs) and copper oxide (CuONPs) nanoparticles using probiotic Lactobacillus acidophilus as a reducing agent. The biosynthesized probiotic Lactobacillus acidophilus selenium and copper oxide nanoparticles were known by color change. The characterization of SeNPs and CuoNPs was completed by Ultraviolet-visible (UV-VIS) spectroscopy, Field Emission Scanning electron microscope (FESEM), Atomic force microscope (AFM), X-Ray diffraction analysis (XRD) and Fourier transform infrared spectroscopy (FTIR). These tests are utilized for detecting stability, morphology, size, crystalline nature and functional groups on nanoparticles prepared surface. Outcomes revealed appearance of the brick-red and green color, representing a specific color of selenium and copper oxide nanoparticles. It was also disclosed that UV-VIS spectroscopy indicated band absorbance at 236 and 264 nanometer of intense surface Plasmon resonance, manifesting the formation and stability of prepared SeNPs and CuONPs. The FESEM image displayed mulit-shapes between spherical and vaulted for selenium and copper oxide nanosized. XRD at 2 theta revealed crystalline selenium and copper oxide nanoparticles where the average size is 75.52-153.22 nm. FTIR revealed the presence of functional groups of the supernatant that act as stabilizing and reducing agents. The antibacterial activity of synthesized nanoparticles was studied against five different bacteria causing food spoilage. As a result of this study, selenium nanoparticle and copper nanoparticles were biosynthized successfully in less time and easy consuming way by green synthesis of the supernatant probiotic Lactobacillus acidophilus.
Evaluation of bacteriophage effect against multidrug-resistant Proteus mirabilis isolated from different clinical samples
Authors: Hussein Mohammed Abdulkadhim , AL- Shwaikh Rana Mujahid Abdullah
Published: November 2024

Proteus mirabilis is a Gram-negative bacterium that can cause a variety of infections including urinary tract infections, respiratory tract infections and wound infections. It is becoming increasingly resistant to antimicrobial agents, and new therapeutic options are urgently needed. Fifty samples were collected from different samples from hospitals in Baghdad city, thirty were found to be positive for Proteus mirabilis. The results showed that most of the Proteus mirabilis isolates were resistant to Cefotaxime (76.6%), Tobramycin and Amikacin (66.7%), Gentamicin (60%), Ciprofloxacin and Ceftazidime (40%). However, Norfloxacin, Amoxicillin / Clavulanic acid and Aztreonam had lower resistance rates of 33.3%, 30%, and 23.3% respectively. The isolates were also tested for multi-drug resistance. Eight different resistance patterns were identified with 24 (80%) of the isolates being resistant to more than three antibiotics. Eleven (36.7%) of the isolates produced β-lactamase enzymes while 8 (26.7%) were able to produce extended-spectrum β-lactamases. Four bacteriophages were isolated from bird droppings, sewage, Tigris river water and soil samples. These phages were able to infect four isolates of the multidrug-resistant bacteria P. mirabilis. A study of the effects of pH and temperature on bacteriophages found that they were able to eliminate bacteria with high efficiency in a pH range of 7 to 9 and at temperatures of 25 to 550C.
Evaluation of the antibacterial activity of AgNPs from Lactobacillus plantarum against Acinetobacter baumannii
Authors: Ahmad Riyam Ghany , Farhan Rana Salim , Attallah Nada Ali , Hameed Ashwaq Talib
Published: November 2024

In this study, we isolated Acinetobacter baumannii in wounds and burn infections and assessed the impact of silver nanoparticles (AgNPs) produced from an external extract of Lactobacillus plantarum secretion on the bacterial growth. Characterization of AgNPs was done using TEM, XRD and FTIR spectroscopy. Inhibition diameters of five concentrations of AgNPs were prepared from Lactobacillus plantarum extracts against A. baumannii. A diameter of 20mm was observed for the highest concentration of 500mg\ml while 16 mm was observed for a concentration of 250mg\ml and 8 mm for the lowest concentration of 50mg\ml. The highest concentration of 500mg\ml showed the most significant inhibition. All concentrations of AgNPs were effective in inhibiting the growth of A. baumannii.
Evaluation of the histological Inflammation in the intestines of male mice infected with Entamoeba histolytica using immunohistochemistry technology
Authors: Khaleel Zinah Ibrahim , Abdulwahhab Intisar Ghanim , Al-Bairuty Genan Adnan Abdullatef
Published: November 2024

The current study was conducted during the period between May 1, 2021 and October 30, 2022 for the purpose of diagnosing infection with the Entamoeba histolytica parasite. The clinically infected patients suffered from diarrhea when the samples were examined microscopically using a sample of direct wet swab. In the experimental study, the Entamoeba histolytica was given to laboratory mice and it was observed that tissue damage appeared as a result of infection with the amoeba parasite, represented by necrosis and explosion in the intestinal villi, dissolution of the epithelial layer and the occurrence of a condensation of inflammatory cells in the intestine.
Electric Field’s Dueling Effects through Dehydration and Ion Separation in Driving NaCl Nucleation at Charged Nanoconfined Interfaces
Authors: Wang Ruiyu , Tiwary Pratyush
Published: November 2024

Investigating nucleation in charged nanoconfined environments is crucial for many scientific and engineering applications. Here we under electric fields is essential for the design of materials. We study the nucleation of NaCl from aqueous solution near charged surfaces using machine-learning-augmented enhanced sampling molecular dynamics simulations. Our simulations successfully drive phase transitions between liquid and solid phases of NaCl. The solid phase is stabilized under electric fields, particularly at an intermediate surface charge density. We examine which physical characteristics drive the nucleation of NaCl from aqueous solutions and find that the removal of solvent water from Cl- at the solid precursor surface plays a more critical role than the accumulation of ions. Our simulations reveal the competing effects of electric fields on nucleation processes: they facilitate the removal of water, promoting nucleation, but also promote the separation of ion pairs thereby hindering nucleation. This work provides a framework for studying nucleation processes in nanoconfined environments under electric fields and physical insights for the design of electrochemistry materials.
Computational Studies on the Functional and Structural Impact of Pathogenic Mutations in Enzymes
Authors: Dissanayake Upeksha C. , Roy Arkanil , Maghsoud Yazdan , Polara Sarthi , Debnath Tanay , Cisneros G. Andrés
Published: November 2024

Enzymes are critical biological catalysts involved in maintaining the intricate balance of metabolic processes within living organisms. Mutations in enzymes can result in disruptions to their functionality, that may lead to a range of diseases. This review focuses on computational studies that investigate the effects of disease-associated mutations in various enzymes. Through molecular dynamics simulations, multiscale calculations, and machine learning approaches, computational studies provide detailed insights into how mutations impact enzyme structure, dynamics, and catalytic activity. This review emphasizes the increasing impact of computational simulations in understanding molecular mechanisms behind enzyme (dis)function by highlighting the application of key computational methodologies to selected enzyme examples, aiding in the prediction of mutation effects and the development of therapeutic strategies.
EVALUATING THE ENERGY EFFICIENCY OF IOT ROUTING PROTOCOLS
Authors:   Department of Energy TERI University New Delhi, Sharma Ankita
Published: November 2024

This research study assesses different routing protocols in the context of the Internet of Things (IoT), emphasizing their energy efficiency. The growth of IoT devices, dependent on finite power sources, needs energy-efficient procedures to optimize device durability. This study methodically evaluates several protocols, analyzing their effects on power consumption within prevalent IoT network topologies. Analysis is offered regarding the impact of each protocol on the sustainability and efficiency of IoT systems, aiding in the formulation of efficient routing solutions.
PROTOCOLS FOR QUANTUM-RESISTANT NETWORKS
Authors:   Associate Consultant Capgemini Gurugram, India, Sharma Ankita
Published: November 2024

With the progression of quantum computing technology, traditional cryptographic protocols encounter flaws that may compromise their efficacy against quantum-based assaults. This study examines quantum-resistant protocols that include post-quantum cryptography (PQC) to enhance the security of existing network protocols, particularly the Transport Layer Security (TLS) protocol. This research examines the efficiency, compatibility, and adaptability of post-quantum algorithms, including lattice-based, code-based, and hash-based cryptographic methods, inside the TLS protocol architecture. The study's findings emphasize the comparative performance metrics and compatibility factors, providing insights into the future of secure network communications in the post-quantum age.
Challenges and Solutions in Mutual Redistribution of Routing Protocols
Authors:   Senior Specialist HCL Technologies Ltd, Noida, INDIA, Sharma Ankita
Published: November 2024

Mutual route protocol redistribution poses some major difficulties when dealing with heterogeneous network infrastructures. The key technical and operational problems of protocol redistribution, such as routing loops, administrative distance conflicts, metric incompatibility, and policy control complexity, will be discussed. We suggest a number of optimized solutions for better protocol interoperability and efficient network performance. Particular emphasis is given to the solutions regarding route filtering, administrative distance tuning, and metric conversion techniques. These approaches further minimize not only potential loop scenarios but also help maintain stability and scalability of network operations across multi-protocol infrastructures.
Resilience of Networks in Intelligent Urban Environments
Authors:   Senior Specialist HCL Technologies Ltd. Noida, India, Sharma Ankita , Arora Prateek ,   School of Business University of Dundee Dundee, Scotland, United Kingdom
Published: November 2024

As urban areas develop to integrate new technology, smart city infrastructures depend significantly on seamless and resilient networks for operational stability, safety, and service continuity. This article examines the essential significance of robust network infrastructure in smart cities and emphasizes techniques aimed at maintaining uninterrupted connectivity during disasters, network failures, or peak demand periods. This article seeks to deliver a thorough analysis of resilient network practices that protect vital infrastructure, sustain data flows, and facilitate key services by investigating real-world case studies, contemporary best practices, and available technology. Principal findings underscore the incorporation of decentralized networking models, adaptive routing protocols, and hybrid connectivity systems as vital components in enhancing smart city resilience.
LEGAL INSTRUMENTS OF COMBATING LEGALIZATION (LAUNDERING) OF PROCEEDS OF CRIME IN CONDITIONS OF DIGITAL EVOLUTION OF THE REPUBLIC OF KAZAKHSTAN
Authors:   AL-FARABI KAZAKH NATIONAL UNIVERSITY, Yerkenov Bolat
Published: November 2024

The article investigates domestic legal instruments used in combating legalization (laundering) of proceeds of crime in the conditions of digital criminal development. The purpose of this article is to introduce the results of the authors’ research area to the scientific community. Legalization (laundering) of proceeds of crime poses a serious threat to the financial stability and economic security of the state as a whole. One of the factors having a negative impact on the traditional financial system has become the spread of digital assets, including cryptocurrencies, NFT – tokens, the volume of transactions has an annual exponential growth. The main principle of legalization of criminal proceeds assumes complete disclosure of criminal activities from law enforcement and controlling authorities and their further in-volvement in legitimate economic activities, as blockchain technologies allow to perform these activities anonymously. Measures taken by state authorities to prevent criminal legalization (laundering) of money and proceeds, such as regulations, financial transaction monitoring systems, international cooperation and measures to strengthen financial transparency are analyzed. The development, adoption and imple-mentation of a comprehensive system of measures aimed at protecting the rights and legitimate interests of citizens and society, the state and the organization of the legal mechanism in combating money laun-dering requires the adoption and consistent implementation of effective measures. The significance of the performed research resides in the possibility of application of the obtained results in the field of combating criminal legalization (laundering) of proceeds. In the course of the re-search, the article highlights the issues of efficiency and possible upgrading of legal instruments in the context of combating criminal legalization (laundering) of proceeds in Kazakhstan. Emphasis is placed on the efficiency of these instruments and possible implementation difficulties.
THE INSTITUTION OF RECONCILIATION IN TURKISH LAW
Authors:   AL-FARABI KAZAKH NATIONAL UNIVERSITY, Güloğlu Yavuz
Published: November 2024

According to the legal system currently applied in Turkey, the state initiates a public prosecution against individuals who commit crimes, and these individuals are punished after being tried in judicial courts. While this system has been in use for many years, the reconciliation procedure has recently been adopted in the Turkish legal system. Reflecting the restorative justice system inherent in our culture, the institution of reconciliation has emerged as an alternative path in our criminal justice system. The reconciliation procedure aims to restore the public order disrupted by the crime of the suspect or defen-dant through the parties’ agreement before a court trial, facilitating the reintegration of the offender into society, while also ensuring quick compensation for the victim. The reconciliation institution, applied during the investigation phase, prevents the initiation of criminal proceedings against offenders, thereby alleviating the burden on the judicial prosecution phase. The reconciliation process serves to conclude potential criminal cases by enabling the parties to reach an agreement of their own free will, thus elimi-nating the threat of criminal investigation and prosecution. The reconciliation procedure concludes more quickly than criminal trials, thereby relieving the offender from prolonged judicial pressure, and if the victim consents to the proposed compensation, their losses are promptly recovered
LEGAL ISSUES OF ECONOMIC SUPPORT FOR PERSONAL SUBSIDIARY FARMS OF CITIZENS IN THE REPUBLIC OF KAZAKHSTAN
Authors:   AL-FARABI KAZAKH NATIONAL UNIVERSITY, Ozenbayeva Aigerim , Algaziyev Marlen , Ibrayev Alisher , Orakbayeva Elmira , Shaldarbekova Manat
Published: November 2024

This article addresses the legal challenges of providing economic support to personal subsidiary farms (PSFs) in the Republic of Kazakhstan. PSFs play a crucial role in the agricultural sector, contribut-ing to food security and economic stability in rural areas. Despite their importance, private investment funds often encounter numerous issues, particularly in accessing economic support and legal protection. However, effective functioning and development of PSFs require economic stimulus measures and legal support. The article analyzes existing legal mechanisms of support, such as credit, subsidies, and pref-erential taxation, identifying shortcomings in their implementation. Attention is focused on legislative imperfections and practical challenges. Additionally, issues of PSF insurance and providing agricultural equipment through leasing as economic stimulus measures are discussed. The subject of the study is the legal mechanism of economic support for private farming of citizens in Kazakhstan. The conclusions underscore the significance of a comprehensive approach to legal regulation and economic support for PSFs in Kazakhstan, including legislative improvements, enhancement of financial mechanisms, and infrastructure development. The author provides recommendations for improving legal norms and imple-menting effective support mechanisms, which can contribute to enhancing the economic well-being of rural residents and the overall development of the agricultural sector.
NYAYA-VAISESIKA ON NUMBER AND ITS PERCEPTION
Authors: Biswas Monalisha
Published: November 2024

The Nyaya and the Vaisesika system are two arthodox (astika) system of Indian Philosophy meaning they admit the Vedas as eternal and infallible that preexist the common era. In their early history, the Nayay and Vaisesika were two Independent system with their own respective metaphysics, epistemology, logic, ethics and solerious. Overtime, the Vaisesika system become so entwined with the Nyaya to the extent that until recently, there was he Independent history of the Vaisesika as a basic system. One reason for addverssing these two systems together is that share many important tents; both systems are committed to common – sense realism and pluralism in their ontology; believe in the creation of the world from material atmos that conjoin to generate. This world by the will of God and in accordance with the accumulated merits and demerits of individual agent. In my article I want to discuss about the Nyaya-vaisesika on number and its perception.The Nyaya-Vaisesika account of number is based on an analysis of our actual - cognitions like 'one', 'two', 'three', etc. They raised the different problems regarding number neither from their interest in mathematics nor from a logistic point of view. We use number words like 'one', 'two', 'three', etc, which in this view designate numbers one, two, three, etc. And numbers for them are as much qualifying features of substances as the qualities like colour, taste, etc. are. They hold a realistic view of number, but such realism should not be confused with Platonism, because numbers in their system are not eternal, timeless, self-subsistent entities known in a priori intuition. A peculiarity of the Nyaya-Vaisesika treatment of number should be noted. The number words like 'one' or 'two', do not refer to any single number like one or two. In fact they admit many ones many, twos many threes, etc.
Methamphetamine intoxication and related emergency situations
Authors: Rush Carole , Walton Steve
Published: November 2024

A 19-year-old male arrives by ambulance at the emergency department with a chief complaint of polysubstance abuse. He has been camping with friends for the past three days, during which he apparently consumed quantities of alcohol, Ecstasy, ‘mushrooms’ and crystal methamphetamine. His friends had called an ambulance after the patient was found unresponsive. On arrival, the patient was combative, verbally abusive, dehydrated, cold and wet. He was reported to have not slept for the past three days. During his 12-hour stay in the emergency department, he required respiratory support, intravenous fluids, benzodiazepines, physical restraints and close monitoring. He was discharged in the care of his father. Clinical management of patients with polysubstance abuse can be complicated, especially if the patient history is vague. This article will focus on acute methamphetamine intoxication and related emergency situations surrounding this drug.
Clinical nursing experience in the emergency department
Authors: Batiuk Tayne
Published: November 2024

An outbreak of MRSA/VRE and subsequent closure of the 4D nursing unit forced the University of Saskatchewan College of Nursing to seek alternate sites for clinical experience. Fortunately, the two emergency departments were able to accommodate the Year III students. Although the course intents are levelled for care of patients admitted to a hospital unit, we believe that with adequate supports and supervision, junior students can acquire some of the competencies required in an emergency department. Normally in the University of Saskatchewan BScN program, emergency is a fourth-year experience. The College of Nursing is currently working with the Regina Qu’Appelle Health Region to increase the numbers of students receiving that experience.
Collaborative development of a standardized trauma admission set
Authors: Pereira Asha , Collis Kathy , Gillman Lawrence M.
Published: November 2024

Patients with severe injuries require the complex integration of care between medicine, nursing, and allied health services. Increasing patient volumes, clinic visits, and a regional directive to improve patient flow have added pressure for all members of the trauma team from the emergency department to the wards and to the outpatient clinics. With increasing workload, concerns emerged regarding the lack of consistency in practice. The decision was made to develop a process to standardize and improve the admission process for trauma patients. After a lengthy collaborative process, an assessment booklet, order set and medication administration record (MAR) were developed and implemented in a large tertiary care facility.
Noninvasive biomarkers in the diagnosis of nonalcoholic fatty liver disease
Authors: Dudanova O.P.
Published: November 2024

This article presents information about traditional and proprietary fibrosis and steatosis scales in nonalcoholic fatty liver disease (NAFLD): NAFLD fibrosis score, BARD, FIB-4, APRIL, FLI, HSI, LAP, and others. Noninvasive methods of NAFLD recognition have a number of advantages over histological examination of liver biopsy specimens and instrumental methods – ultrasound and magnetic resonance elastography. They contain simple, accessible and inexpensive clinical and laboratory parameters that allow estimating the severity of NAFLD and predictors of its unfavorable course. Domestic and foreign authors proved a close association of these scales with morphological and sonographic signs of NAFLD. These fibrosis and steatosis scales are recommended for use as first-line diagnosis in primary care settings for population-based studies
Ulcerous disease in nurse practice
Authors: Skvortsov V.V. , Taikinova A.S. , Faiziyeva V.R.
Published: November 2024

This article is a literary review, highlights issues related to the etiology, classification, pathogenesis, clinical symptoms, approaches to the diagnosis and effective complex therapy of peptic ulcer of the duodenum. However, the pylori tag plays an important role in the pathogenesis of YAB. Currently, the arsenal of eradication protocols is quite extensive. The choice of the eradication treatment option should take into account the population antibiotic resistance and the individual history of antibiotic use. According to research, the use of the first line of quadrotherapy is considered the most effective.
Cuidar com Dignidade: Fundamentos e Práticas em Cuidados Paliativos
Authors: BORGES JOÃO VÍCTOR SIQUEIRA AFONSO , VILLA ISADORA FIGUEIREDO , FRUTUOSO GIOVANNA DE MOURA , TELES ANA BEATRIZ CARVALHO , LOPES PAOLLA SANTIAGO QUEIROZ , MENDES PEDRO HENRIQUE ABBADE , OLIVEIRA FRANCYELLY SANTOS DE , RABELO THAISE DE CÁSSIA MONTEIRO MONTEIRO , SANTOS LETÍCIA VITÓRIA DA SILVA , SOUSA JOYCE CAROLINE DE OLIVEIRA , OLIVEIRA THELLYSSON FARIAS DE , TEIXEIRA PEDRO HENRIQUE MOURA , MARQUES DANIELA FERREIRA , RAMOS GUSTAVO ALMEIDA , LIMA KASSYA FERNANDA FREIRE , LIMA ELAYNNE JEYSSA ALVES , GUIMARÃES PAULYNE SOUZA SILVA , FERREIRA BARBARA RODRIGUES , LUZ ANA CLAUDIA SANTOS DA , AMORIM ADRIANO OLIVEIRA
Published: November 2024

A 2ª Edição do livro "Cuidar com Dignidade: Fundamentos e Práticas em Cuidados Paliativos" é uma obra essencial para profissionais de saúde que atuam na área de cuidados paliativos, oferecendo uma abordagem abrangente e humanizada sobre o cuidado de pacientes com doenças graves e em fases. avançado. Atualizada com as mais recentes práticas e avanços científicos, esta nova edição mantém o foco na dignidade e na qualidade de vida, destacando o papel central do cuidado integral, que abrange as dimensões físicas, emocionais, sociais e espirituais do paciente.
A obra explora os princípios fundamentais dos cuidados paliativos, como o alívio da dor e do sofrimento, o suporte emocional para pacientes e familiares, a comunicação sensível em situações de terminalidade e a tomada de decisões compartilhadas. Além disso, apresenta estudos de caso, diretrizes clínicas, estratégias de manejo de sintomas e orientações para a prática interdisciplinar, reforçando a importância do trabalho colaborativo entre médicos, enfermeiros, psicólogos, assistentes sociais e outros profissionais envolvidos no cuidado.
Com contribuições de especialistas renomados, a 2ª edição de "Cuidar com Dignidade" é um guia prático e reflexivo, destinado a profissionais da saúde, estudantes e cuidadores que buscam aprimorar suas práticas e oferecer um cuidado compassivo e ético, centrado nas necessidades e desejos do paciente. A obra reafirma a importância de cuidar com empatia, promovendo a dignidade e o conforto em todas as fases da vida.
Overcoming Gravity: Celan, Nietzsche, and Nihilism
Authors: Dong Feng
Published: November 2024

Abstract: The free-floating objects in Celan’s 1960s poems are more than astronomical and mystical phenomena; read ontologically, they reveal the imprint of Nietzschean nihilism. The loss of gravity in Celan’s middle and later poetry ciphers his dizzy sense of living in a postwar Europe where he has to work through fallen values by opening his poetry up to unknown configurations and dimensions of nihil. Although Celan is reluctant to resort to Will to Power to fight nihilism, he seeks to give space for the nothing, to make sense (if not a meaning) out of it in light of Nietzschean Eternal Return. His free-floating astral bodies, simultaneously embodying the heaviness and lightness of being, maintain nihil in an open, poetic, non-nihilistic atmosphere where nihil is set in motion but de-absolutized in the poetic horizon.