bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of Perspective Oat Cultivars with a Minimum Content of Gluten Homologous Peptides
Authors: Dvořáček Václav , Kotrbová-Kozak Anna , Kozová-Doležalová Jana , Jágr Michal , Hlásná Čepková Petra , Kosová Klára
Published: October 2020

There is still an ambiguous opinion on oat regarding its safety for people with celiac disease (CD). Some studies have confirmed different content of oat immunoreactive epitopes in different cultivars while others explain the differences in consequence of cross-contamination with gluten-rich species or as ELISA cross-reactivity of oat homological epitopes with antibodies against wheat gliadin. Our study was based on a two-year mapping of oat immunoreactive epitopes in a set of 132 oat cultivars using the G12-based ELISA kit. Although repeated evaluation confirmed high interannual variability (RSD ≥ 30%) in approximately 2/3 of the cultivars, the permitted gluten content (20 mg kg-1) has not been exceeded except for contaminated cultivar Sirene. The polymorphism of purified avenins determined by SDS-PAGE revealed the occurrence of 2 bands around 30 kDa in oat cultivars with relatively high gluten content (12-16 mg kg-1) except for the cultivar Leo while this pattern occurred only in 50% oat cultivars with low gluten content. Quantification of gluten epitopes on purified avenin unit further revealed the three materials (Mojacar, Maris Oberon, SG-K 16370) with the lowest gluten content and presence of one band at 30 kDa. The band pattern at 30 kDa thus represents a promising breeding marker.
Assessment of Human Gingival Fibroblast Proliferation After Laser Stimulation In Vitro Using Different Laser Types and Wavelengths (1064, 980, 635, 450 and 405nm) – Preliminary Report
Authors: Sterczała Barbara , Grzech-Leśniak Kinga , Michel Olga , Trzeciakowski Witold , Jurczyszyn Kamil
Published: October 2020

Purpose: to assess the effect of photobiomodulation (PBM) on human gingival fibroblast proliferation. Methods: The study was conducted using the primary cell cultures of human fibroblasts collected from systemically healthy donors. Three different laser types: Nd:YAG (1064nm), infrared diode laser (980nm) and prototype led laser emitting 405, 450 and 635nm were used to irradiate fibroblasts. Thanks to the patented structure of that laser, it was possible to irradiate fibroblasts with a beam combining two or three wavelengths. The energy density was 3 J/cm², 25 J/cm², 64 J/cm². The viability and proliferation of cells were determined using the MTT test conducted 24, 48 and 72 hours after laser irradiation. Results: The highest percentage of mitochondrial activity (MA=122.1%) was observed in the group irradiated with the 635nm laser, with an energy density of 64 J/cm² after 48 hours. The lowest percentage of MA (94.0%) was observed in the group simultaneously irradiated with three wavelengths (405 + 450 + 635 nm). The use of the 405nm laser at 25 J/cm² gave similar results to the 635 nm laser. Conclusions: The application of the 635nm and 405nm irradiation caused a statistically significant increase in the proliferation of gingival fibroblasts.
Flax Fiber for Technical Textile: A Life Cycle Inventory
Authors: Gomez-Campos Alejandra , Vialle Claire , Rouilly Antoine , Sablayrolles Caroline , Hamelin Lorie
Published: October 2020

Flax fiber appears as a suitable feedstock in the endeavor of deploying a sustainable biobased economy. Its environmental performance as reinforcement in composite materials has been studied in previous Life Cycle Assessments (LCAs). However, these studies only present a coarse Life cycle Inventory (LCI) and often fail to detail all processes of the supply chain or to represent the co-products. This paper aims to bridge this gap and provide data for future LCAs on flax fiber production and transformation.The study focuses on the impacts of producing a bio-based reinforcement material (a fabric product for non-aesthetic purposes) with a system expansion perspective. The functional unit is defined as the production of 2400 m² flax-based technical textile per year, this corresponds to one hectare of cultivated land. The geographical scope considers that the production occurs in France and that some manufacturing process are outsourced in China. A Sensitivity Analysis was carried out to assess the influence of the electricity mix in the various countries involved in the manufacturing cycle.A detailed life cycle inventory for flax fiber production and transformation was built and the environmental performance of a flax technical textile was assessed as a cradle-to-gate LCA. The fate of co-products was documented and was shown to contribute to the reduction of the generated environmental impacts. Through a cradle-to-gate LCA, a broader understanding of the environmental performance of a flax-based technical textile was presented by including the valorization of co-products and a wider set of analyzed impact categories, going therefore beyond the existing state-of-the-art. Results show agricultural activities and electricity production to be the biggest contributors to the environmental impacts of flax technical textile; contributions due to land use changes were minor in comparison. Very specifically for this case study, a sensibility analysis showed the influence of an all-French production to be more efficient from an environmental point of view.
PERBANDINGAN MODEL PEMBELAJARAN KOOPERATIF TIPE FAN N PICK DAN TEAM GAMES TOURNAMENT TERHADAP KEMAMPUAN PEMAHAMAN MATEMATIS SISWA SMA NEGERI DI CIBINONG
Authors: Hajizah Mimi Nur , Putri Nadhifa Ismaya , Purwanto Swida
Published: October 2020

Abstrak

Penelitian ini bertujuan untuk mengetahui apakah kemampuan pemahaman matematis siswa yang belajar menggunakan model pembelajaran Fan N Pick lebih tinggi daripada Team Games Tournament. Penelitian dilakukan di dua sekolah, yaitu SMAN 1 Cibinong dan SMAN 2 Cibinong kelas XI IPA semester genap tahun ajaran 2018-2019 pada pokok bahasan limit fungsi. Metode penelitian yang digunakan adalah quasi eksperiment. Teknik pengambilan sampel menggunakan teknik purposive sampling dan cluster random sampling. Instrumen penelitian yang digunakan adalah tes kemampuan pemahaman matematis pada pokok bahasan limit fungsi sebanyak empat soal uraian. Instrumen tersebut telah melalui uji validitas isi, validitas konstruk, dan validitas empiris. Perhitungan reabilitas dilakukan menggunakan rumus Alpha Cronbach dan diperoleh koefisien reabilitas sebesar yang termasuk dalam kategori sedang. Berdasarkan perhitungan data hasil penelitian, data kesepuluh kelas berasal dari populasi berdistribusi normal dan memiliki varians sama atau homogen. Oleh karena itu, pengujian hipotesis statistic dilakukan menggunakan statistic uji-t pada taraf signifikansi Î± = 0,05. Berdasarkan hasil pengujian diperoleh = 2,4696 dan = 1, 9768. Nilai yang berarti tolak . Dengan demikian dapat disimpulkan kemampuan pemahaman matematis siswa yang belajar menggunakan model pembelajaran Fan N Pick lebih tinggi daripada kemampuan pemahaman matematis siswa yang belajar menggunakan model pembelajaran Team Games Tournament.
Peningkatan Kemampuan Pemecahan Masalah Matematis Siswa Melalui Model Pembelajaran Inkuiri Terbimbing Pada Materi SPLDV Kelas VIII-C SMPN 196 Jakarta
Authors: Apriyani Mifta Putri , Wijayanti Dwi Antari
Published: October 2020

ABSTRAK

Penelitian ini bertujuan untuk meningkatkan kemampuan pemecahan matematis siswa dalam pembelajaran matematika melalui model pembelajaran inkuiri terbimbing pada materi SPLDV di kelas VIII-C SMPN 196 Jakarta. Penelitian ini merupakan penelitian tindakan kelas. Tahapan yang dilakukan yaitu perencanakan, pelaksanaan, analisis dan refleksi. Tindakan dilakukan dalam tiga siklus yang terdiri dari dua pertemuan di setiap siklusnya. Langkah-langkah penerapan model inkuiri terbimbing meliputi exploration, concept formation dan application. Analisis data dilakukan secara kuantitatif dan kualitatif. Data yang dianalisis secara kuantitatif berupa hasil tes kemampuan pemecahan masalah matematis siswa, sedangkan data yang dianalisis secara kualitatif berupa wawancara, lembar observasi, dan hasil dokumentasi. Hasil penelitian menunjukkan bahwa pembelajaran matematika melaui model inkuiri terbimbing dapat meningkatkan kemampuan pemecahan masalah matematis siswa kelas VIII-C SMPN 196 Jakarta. Jumlah persentase kemampuan pemecahan masalah matematis siswa kelas VIII-C adalah 84,85% atau sebanyak 28 siswa dari 36 siswa memasuki kategori tinggi dan sangat tinggi. Nilai rata-rata tes kemampuan pemecahan masalah matematis siswa pada kelas VIII-C memasuki kategori tinggi pada interval 61-80 dengan nilai rata-rata 70,1394. Selain itu juga terjadi peningkatan nilai tes kemampuan pemecahan masalah pada masing-masing subjek penelitian. Peningkatan yang dicapai SP1 adalah 85,71 pada siklus I, 89,28 pada siklus II dan 100 pada siklus III. Peningkatan yang diperoleh SP2 adalah 82,14 pada siklus I, 85,71 pada siklus II dan 92,85 pada siklus III. Peningkatan yang dicapai SP3 adalah 71,42 pada siklus I, 85,71 pada siklus II dan 96,42 pada siklus III. Peningkatan yang dicapai SP4 adalah 64,28 pada siklus I, 82,14 pada siklus II dan 89,28 pada siklus III, Peningkatan yang dicapai SP5 adalah 71,42 pada siklus I, 82,14 pada siklus II dan 96,42 pada siklus III. Peningkatan yang dicapai SP6 adalah 39,28 pada siklus I, 60,71 pada siklus II dan 78,57 pada siklus III. Berdasarkan hasil tersebut, dapat disimpulkan bahwa melalui model inkuiri terbimbing dapat meningkatkan kemampuan pemecahan masalah matematis siswa kelas VIII-C SMPN 196 Jakarta.
Pengaruh Model Pembelajaran Kooperatif Tipe Round Table Terhadap Kemampuan Komunikasi Matematis Siswa SMAN 101 Jakarta
Authors: Morainauli Belva Yessica Grace
Published: October 2020

This study aims to determine whether the Round Table cooperative learning model influences the mathematical communication skills of students of SMAN 101 Jakarta. This research was conducted in the even semester of the 2018/2019 academic year on the subject of Lines and Series. The research method used was quasi-experimental. The target population of this study were all students of SMAN 101 Jakarta and the affordable population in this study were students of XI MIPA. The sampling technique uses cluster random sampling technique. The research instrument used was a test of mathematical communication skills as many as four description questions. the instrument has gone through content validation tests, construct validation and empirical validation. After the instrument is valid, reliability is tested where the correlation coefficient obtained is 0.5602. After testing the normality, homogeneity and similarity of averages and cluster random sampling. XI MIPA 2 was chosen as the control class and XI MIPA 4 as the experimental class. Based on the calculation of the research data of the two classes, each of them is normally distributed and has the same or homogeneous variance. Therefore, hypothesis testing is done by using t-test statistics with a significant level Î± = 0.05. Based on the results of the test, the value of tcount = 2.43499 and t table = 1.6682 is obtained, so that it gets tcount> ttable. So reject H0. This shows that there is the influence of Round Table cooperative learning model on mathematical communication skills of students of SMAN 101 Jakarta.
Meningkatkan Kemampuan Pemecahan Masalah Matematis pada Materi Lingkaran melalui Model Pembelajaran Means Ends Analysis (MEA) pada Peserta Didik Kelas VIII.A SMP Negeri 7 Jakarta Timur
Authors: Rezky Maskanur , Salsabila Ellis , Sari Puspita
Published: October 2020

Maskanur Rezky1, a), Ellis Salsabila2, b), Puspita Sari3, c)

123 Universitas Negeri Jakarta

 

Email: maskanur.rezky@yahoo.co.id1, ellissalsabila@yahoo.com, pipit_1945@yahoo.com

Abstrak

Penelitian ini bertujuan untuk meningkatkan kemampuan pemecahan masalah matematis pada peserta didik kelas VIII.A SMP Negeri 7 Jakarta pada materi lingkaran melalui model pembelajaran Means Ends Analysis (MEA). Berdasarkan hasil observasi, wawancara serta test kemampuan awal pemecahan masalah matematis di kelas tersebut terlihat bahwa kemampuan pemecahan masalah matematis yang dimiliki masih rendah, sehingga perlu ditingkatkan. Penelitian ini merupakan Penelitian Tindakan Kelas (PTK) yang dilaksanakan dalam tiga siklus dengan subjek penelitian sebanyak enam orang yang mewakili peserta didik dengan kemampuan akademik tinggi, sedang dan rendah. Hasil penelitian menunjukan bahwa pembelajaran matematika pada materi lingkaran dengan model pembelajaran MEA melalui sintaks means, analysis dan ends dapat meningkatkan kemampuan pemecahan masalah matematis peserta didik melalui proses diskusi dalam menyelesaian masalah yang disajikan melalui lembar kerja. Peningkatan kemampuan pemecahan masalah matematis juga dapat ditunjukan dengan meningkatnya nilai rata-rata yang diperoleh pada test kemampuan awal 29,2, siklus I diperoleh 67,53, siklus II diperoleh 69,71 dan siklus III diperoleh 72,86. Selain itu, persentase peserta didik yang memperoleh kategori baik pada interval nilai 60-80 juga meningkat, yakni pada test kemampuan awal sebanyak 3,03%, siklus I sebanyak 69,44%, siklus II sebanyak 77,78% dan siklus III sebanyak 93,74%.

 

Kata kunci: kemampuan pemecahan masalah matematis, model pembelajaran means ends analysis (MEA)
Апротинин — новый мультитаргетный препарат-кандидат или «волшебное решение» для терапии COVID‐19
Authors: Иващенко Андрей , Свистунов Андрей , Хоробрых Татьяна , Логинов Владимир , Карапетян Рубен , Мищенко Наталья , Поярков Станислав , Топр Михаил , Волгин Максим , Якубова Елена , Иващенко Александр
Published: October 2020

Апротинин показал высокую эффективность и безопасность в проспективном исследовании комбинированной терапии госпитализированных пациентов с пневмонией COVID-19 средней и тяжелой степени тяжести
The Invasion Depth Measurement of Bladder Cancer using T2-weighted Magnetic Resonance Imaging
Authors: liu yang , Zheng Haojie , Xu Xiaopan , Zhang Xi , Du Peng , Liang Jimin , Lu Hongbing
Published: October 2020

Background: Invasion depth is an important index for staging and clinical treatment strategy of bladder cancer (BCa). The aim of this study was to investigate the feasibility of segmenting the BCa region from bladder wall region on MRI, and quantitatively measuring the invasion depth of the tumor mass in bladder lumen for further clinical decision-making. This retrospective study involved 20 eligible patients with postoperatively pathologically-confirmed BCa. It was conducted in the following steps: (1) a total of 1159 features were extracted from each voxel of both the certain cancerous and wall tissues with the T2-weighted (T2W) MRI data; (2) the support vector machine (SVM)-based recursive feature elimination (RFE) method was implemented to first select an optimal feature subset, and then develop the classification model for the precise separation of the cancerous regions; (3) after excluding the cancerous region from the bladder wall, the three-dimensional bladder wall thickness (BWT) was calculated using Laplacian method, and the invasion depth of BCa was eventually defined by the subtraction of the mean BWT excluding the cancerous region and the minimum BWT of the cancerous region.Results: The segmented results showed a promising accuracy, with the mean Dice similarity coefficient of 0.921. The “soft boundary” defined by the voxels with the probabilities between 0.1 and 0.9 could demonstrate the overlapped region of cancerous and wall tissues. The invasion depth calculated from proposed segmentation method was compared with that from manual segmentation, with a mean difference of 0.277 mm.Conclusion: The proposed strategy could accurately segment the BCa region, and, as the first attempt, realize the quantitative measurement of BCa invasion depth.
Effects of β-carotene intake on the risk of fracture: A Bayesian meta-analysis
Authors: Charkos Tesfaye Getachew , Liu Yawen , Oumer Kemal Sherefa , Vuong Ann M , Yang Shuman
Published: October 2020

Background: Epidemiological studies examining the association between β-carotene intake and risk of fracture have reported inconsistent findings. We conducted a meta-analysis to investigate the association between β-carotene intake and risk of fracture.

Methods: We systematically searched PubMed, EMBASE and Cochrane library databases for relevant articles that were published until December 2019. We also identified studies from reference lists of articles identified from the clinical databases. The frequentist and Bayesian random-effects model was used to synthesize data.

Results: Nine studies with a total of 190,545 men and women, with an average age of 59.8 years, were included in this meta-analysis. For β-carotene intake (1.76 -14.30 mg/day), the pooled risk ratio (RR) of any fracture was 0.67 (95% Credible Interval (CrI): 0.51-0.82; heterogeneity: P = 0.66, I 2 =0.00 %) and 0.63 (95%CrI: 0.44-0. 82) for hip fracture. By study design, the pooled RRs were 0.55 (95% CrI: 0.14-0.96) for case-control studies and 0.82 (95% CrI: 0.58-0.99) for cohort studies. By geographic region, the pooled RRs were 0.58 (95% CrI: 0.28-0.89), 0.86 (95% CrI: 0.35-0.1.37), and 0.91(95% CrI: 0.75-1.00) for studies conducted in China, the United States, and Europe, respectively. By sex, the pooled RRs were 0.88 (95% CrI: 0.73-0.99) for males and 0.76 (95% CrI: 0.44-1.07) for females. There was a 95% probability that β-carotene intake reduces risk of hip fracture and any type of fracture by more than 20%.

Conclusions: The present meta-analysis suggests that β-carotene intake was inversely associated with fracture risk, which was consistently observed for case-control and cohort studies. Randomized controlled trials are warranted to confirm this relationship.
The Impact of General Self-efficacy and the Severity of Malocclusion on Acceptance of Removable Orthodontic Appliances in 10- to 12-year-old Patients
Authors: Naseri Navid , Baherimoghadam Tahereh , Bassagh Niloofar , Hamedani Shahram , Bassagh Elmira , Hashemi Zahra
Published: October 2020

Background: The patients’ acceptance of a treatment plan and their subsequent cooperation play a crucial role in achieving the best results in orthodontic treatments. Evidences show some personality traits such as general self-efficacy (GSE) and some dental traits such as severity of malocclusion are correlated with motivation of orthodontic treatment. These factors may predict the patients’ compliance and acceptance in using removable orthodontic appliances. This cross sectional study was conducted to assess the correlation of GSE and the severity of malocclusion with patients’ acceptance in using removable orthodontic appliances.Methods:This study recruited 50 patients aged 10-12 years who required removable orthodontic appliances. The severity of malocclusion was determined using the index of orthodontic treatment need (IOTN) before the onset of treatment and GSE of participants were assessed using GSE scale self-report. The acceptance questionnaire was proposed to the patients on first (T1), third (T2), and sixth (T3) month after the delivery of the appliance.Results: The GSE score had a statistically significant correlation with the total score of the acceptance questionnaire, subscale score of satisfaction with the appliance during eating and oral hygiene practice, duration of usage of the appliance, and interest in using it (P<0.05). The IOTN had no significant correlation with the acceptance questionnaire.Conclusions: Our findings substantiate the role of the GSES, concurrently declining the role of the IOTN in prediction of 10-12-year-old children's acceptance and cooperation in treatment of malocclusion with removable appliances.
Risk factors of poor prognosis and impairment of activities of daily living in patients with hemorrhagic gastroduodenal ulcers
Authors: Arai Junya , Kato Jun , Toda Nobuo , Kurokawa Ken , Shibata Chikako , Kurosaki Shigeyuki , Funato Kazuyoshi , Kondo Mayuko , Takagi Kaoru , Kojima Kentaro , Ohki Takamasa , Seki Michiharu , Tagawa Kazumi
Published: October 2020

Background: Impairment of activities of daily living (ADL) due to hemorrhagic gastroduodenal ulcers (HGU) has rarely been evaluated. We analyzed the risk factors of poor prognosis, including mortality and impairment of ADL, in patients with HGU.Methods: In total, 582 patients diagnosed with HGU were retrospectively analyzed. Necessity to look for care facilities to admit or requirement of home modifications during the hospitalization period was defined as ADL decline. The clinical factors were evaluated: endoscopic features, need for interventional endoscopic procedures, comorbidities, symptoms, and medications. The risk factors of outcomes were examined with multivariate analysis.Results: Advanced age (> 75 years) was a significant predictor of poor prognosis, including impairment of ADL. Additional significant risk factors were renal disease (odds ratio [OR], 3.43; 95% confidence interval [CI], 1.44–8.14) for overall mortality, proton pump inhibitor (PPIs) usage prior to hemorrhage (OR, 5.80; 95% CI, 2.08–16.2), and heart disease (OR, 3.05; 95% CI, 1.11–8.43) for the impairment of ADL. Analysis of elderly (> 75 years) subjects alone also revealed that use of PPIs prior to hemorrhage was a significant predictor for the impairment of ADL (OR, 8.24; 95% CI, 2.36–28.7).Conclusion: In addition to advanced age, the presence of comorbidities was a risk of poor outcomes in patients with HGU. PPI use prior to hemorrhage was a significant risk factor for the impairment of ADL, both in overall HGU patients and in elderly patients alone. These findings suggest that the current strategy for PPI use needs reconsideration.
School trajectory disruption among adolescents living with perinatal HIV receiving antiretroviral treatments: a case-control study in Thailand 
Authors: Merville Ophélie , Puangmala Patcharee , Suksawas Pranee , Kliangpiboon Woranut , Keawvilai Waraporn , Tunkam Chorkanikar , Yama Suvimon , Sukhaphan Usa , Sathan Somporn , Marasri Siriporn , Rolland-guillard Louise , Sirirungsi Wasna , Coeur Sophie Le
Published: October 2020

Background: Adolescents living with perinatal HIV often experience difficult living circumstances that can impact educational achievement and thus their transition to adult life. We explored their school trajectories and evaluated the contribution of perinatal HIV-infection, in Thailand, where education is free and compulsory until the age of 15.Methods: We used data from the Teens Living with Antiretrovirals (TEEWA) study, a cross-sectional case-control study conducted from 2011 to 2014 in Thailand. Participants were 707 adolescents living with perinatal HIV (ALPHIV, cases) aged 12–19 receiving antiretroviral therapy in 19 hospitals throughout Thailand and 689 HIV-uninfected adolescents (controls) living in the same institutions or, for those living in family settings, randomly selected from the general population and individually matched for sex, age, and place of residence. School trajectory disruption was defined as ≥ 1 year of academic delay or as early school dropout (before 15 years of age). Logistic regression models were used to assess factors independently associated with disrupted school trajectory and to estimate the proportion of school disruption attributable to HIV-infection. We used multivariate imputations by chained equations (MICE) to manage missing data and performed two sensitivity analyses to evaluate the main model’s reliability.Results: The study population’s median age was 14.5 years (58% female). School trajectory disruption was experienced by 37% of ALPHIV and 12% of the controls. After adjusting for sociodemographic factors, ALPHIV were 5 times more likely to experience disruption than controls ( =5.2 [3.7-7.2]). About 50% of school trajectory disruption was attributable to HIV-infection. Boys and adolescents living in institutions were more likely to experience school trajectory disruption ( =1.8 [1.3-2.4] and =11.0 [7.7-15.8], respectively). Among ALPHIV, neurocognitive difficulties and growth delay were significantly associated with disruption ( =3.3 [2.1-5.2] and =1.8 [1.3-2.6], respectively). For those living in families, disruption was also associated with having a caregiver who had less than a secondary-level education ( =2.1 [1.1-3.9]) or having experienced stigmatization ( =1.9 [1.2-3.1]). Conclusions: HIV and contextual factors combine to aggravate the educational disadvantage among ALPHIV. The impact of this disadvantage on their life prospects, especially regarding access to higher education and professional achievement, should be further explored.
Direct comparison of brain [18F]FDG images acquired by SiPM-based and PMT-based PET/CT: phantom and clinical studies
Authors: Wagatsuma Kei , Sakata Muneyuki , Ishibashi Kenji , Hirayama Akira , Kawakami Hirofumi , Miwa Kenta , Suzuki Yukihisa , Ishii Kenji
Published: October 2020

Background: Silicon photomultiplier-positron emission tomography (SiPM-PET) has better sensitivity, spatial resolution, and timing resolution than photomultiplier tube (PMT)-PET. The present study aimed to clarify the advantages of SiPM-PET in 18F-fluoro-2-deoxy-D-glucose ([18F]FDG) brain imaging in a head-to-head comparison with PMT-PET in phantom and clinical studies.Methods: Contrast was calculated from images acquired from a Hoffman 3D brain phantom and image noise and uniformity were calculated from images acquired from a pool phantom using SiPM- and PMT-PET. Sequential PMT-PET and SiPM-PET [18F]FDG images were acquired over a period of 10 min from 22 controls and 10 patients. All images were separately normalized to a standard [18F]FDG PET template, then mean standardized uptake values (SUVmean) and Z-score were calculated using MIMneuro and CortexID Suite, respectively.Results: Image contrast, image noise, and uniformity in SiPM-PET changed 19.2%, 3.5%, and -40.0% from PMT-PET, respectively. These physical indices of both PET scanners satisfied the criteria for acceptable image quality published by the Japanese Society of Nuclear Medicine of contrast > 55%, CV ≤ 15% and SD ≤ 0.0249, respectively. Contrast was 70.0% for SiPM-PET without TOF and 59.5% for PMT-PET without TOF. The TOF improved contrast by 3.5% in SiPM-PET. The SUVmean using SiPM-PET was significantly higher than PMT-PET and did not correlate with a time delay. Z-scores were also significantly higher in images acquired from SiPM-PET (except for the bilateral posterior cingulate) than PMT-PET because the peak signal that was extracted by the calculation of Z-score in CortexID Suite was increased. The hypometabolic area in statistical maps was reduced and localized using SiPM-PET. The trend was independent of whether the images were derived from controls or patients.Conclusions: The improved spatial resolution and sensitivity of SiPM-PET contributed to better image contrast and uniformity in brain [18F]FDG images. The SiPM-PET offers better quality and more accurate quantitation of brain PET images. The SUVmean and Z-scores were higher in SiPM-PET than PMT-PET due to improved PVE. [18F]FDG images acquired using SiPM-PET will help to improve diagnostic outcomes based on statistical image analysis because SiPM-PET would localize the distribution of glucose metabolism on Z-score maps.
Effect of nutrition education on iodine deficiency disorders and iodized salt intake in south west Ethiopian women: a cluster randomized controlled trial
Authors: Asfaw Agize , Belachew Tefera , Gari Taye
Published: October 2020

Background: Although iodine nutrition status is improving globally, the progress is not uniform throughout the world due to several factors. Among these, poor knowledge, negative attitude and improper practice of iodized salt are the main risk factors for poor iodine nutrition in Ethiopia. This study was aimed to assess the effect of nutrition education intervention on knowledge, attitude and practice (KAP) of iodine deficiency and iodized salt utilization.Methods: A cluster randomized controlled trial was carried out among 652 women of reproductive age group in southwest Ethiopia. A total of 24 clusters were selected and randomized in to an intervention and control villages. Women in the intervention village received iodine nutrition related education for six months; while those in the control village did not receive any education. Baseline and endline data were collected from both groups. Generalized Estimating Equations (GEE) was used to determine the effect of intervention.Results: A total of 647 (99.2%) participants were successfully involved in the study. In the intervention group the median attendance was 10 out of 12 sessions. Women in the intervention group had shown statistically significant change in knowledge, attitude and practice scores as compared to control one. In multivariable GEE linear model, after adjusting for other background characteristics, the mean difference (95% CI) scores were 8.81 (8.46, 9.16) for knowledge, 3.35 (3.17, 3.54) for attitude and 2.90 (2.74, 3.05) for practice in the intervention arm. Conclusions: Well designed and community-based iodine nutrition education is an effective strategy to improve the KAP of iodine deficiency disorders and iodized salt utilization.Trial registration: PACTR201809544276357 (Retrospectively registered on 14, Sept. 2018).http: //www.pactr.org
The impact of disease-related immobilization on thigh muscle mass and strength in frail older hospitalized patients
Authors: Rommersbach Nikola , Wirth Rainer , Lueg Gero , Klimek Christiane , Schnatmann Mirja , Liermann Dieter , Janssen Gregor , Müller Manfred James , Pourhassan Maryam
Published: October 2020

Background: We assessed the quantitative changes in muscle mass and strength during two weeks of hospitalization in immobile and mobile acutely ill hospitalized older adults.Methods: 41 patients (82.4±6.6 years, 73.0% females) participated in this prospective longitudinal observational study. Mobility status was defined according to walking ability as described in the Barthel-Index. Functional status, including handgrip strength and isometric knee-extension strength, and mid-thigh magnetic resonance imaging (MRI) measurements of cross-sectional area (CSA) were conducted on admission and at discharge. Results: Twenty-two participants (54%) were immobile and 19 (46%) mobile. In all, 54.0% and 12.0% were at risk of malnutrition and malnourished, respectively. The median time between baseline and follow-up for MRI scans were 13 days in mobile and immobile participants (P=0.072). Mid-thigh muscle and subcutaneous fat CSA significantly decreased by 3.9cm2 (5.0%, P=0.002) and 5.3cm2 (5.7%, P=0.036) during hospitalization whereas intermuscular fat remained unchanged in immobile subjects. No significant changes were observed in mobile patients. In a regression analysis, mobility was the major independent risk factor for changes in mid-thigh muscle CSA as a percentage of initial muscle area (P=0.022) whereas other variables such as age (P=0.584), BMI (P= 0.879), nutritional status (P=0.835) and inflammation (P=0.291) were not associated with muscle mass changes. There was a significant decrease in isometric knee extension strength (P=0.002) and no change in handgrip strength (P=0.167) in immobile patients whereas both parameters increased significantly over time in mobile patients (P=0.048 and P=0.012, respectively).Conclusions: Two weeks of disease-related immobilization result in a significant loss of thigh muscle mass and muscle strength in older patients with impaired mobility. Concomitantly, there was a significant reduction of subcutaneous adipose tissue in immobile older hospitalized patients whereas no changes were observed in intermuscular fat among these patients. These data highlight the importance of mobility support in maintaining muscle mass and function in older hospitalized patients.
Onodera’s prognostic nutritional index is a strong prognostic indicator for patients with hepatocellular carcinoma after initial hepatectomy, especially patients with preserved liver function
Authors: Tanemura Akihiro , Mizuno Shugo , Hayasaki Aoi , Gyoten Kazuyuki , Fujii Takehiro , Iizawa Yusuke , Kato Hiroyuki , Murata Yasuhiro , Kuriyama Naohisa , Kishiwada Masashi , Sakurai Hiroyuki , Isaji Shuji
Published: October 2020

Background Several inflammation-based scores are used to assess the surgical outcomes of hepatocellular carcinoma (HCC). The aim of the present study was to elucidate the prognostic value of the prognostic nutritional index (PNI) in HCC patients who underwent hepatectomy with special attention to preoperative liver functional reserve.Methods Preoperative demographic and tumor-related factors were analyzed in 189 patients with HCC undergoing initial hepatectomy from August 2005 to May 2016 to identify significant prognostic factors.Results Multivariate analysis for overall survival (OS) revealed that female sex (p=0.005), tumor size (p<0.001) and PNI (p=0.001) were independent prognostic factors. Compared to the High PNI group (PNI ≥37, n=172), the Low PNI group (PNI <37, n=17) had impaired liver function and significantly poorer OS (13% vs. 67% in 5-year OS, p=0.001) and recurrence-free survival (RFS) (8 vs. 25 months in median PFS time, p=0.002). In the subgroup of patients with a preserved liver function of LHL15 ≥0.9, PNI was also independent prognostic factor, and OS (21% vs. 70% in 5-year OS, p=0.008) and RFS (8 vs. 28 months in median PFS time, p=0.018) were significantly poorer in the Low PNI group than the High PNI group.Conclusions PNI was an independent prognostic factor for HCC patients who underwent hepatectomy. Patients with PNI lower than 37 were at high risk for early recurrence and poor patient survival, especially in the patients with preserved liver function of LHL ≥0.9.
A Research of self-help ventilator Sharing based on Internet of Things in Hospital
Authors: Chen XB , An Z , Li TQ , Duan J , Song DJ , Lin Y , Wu QL , Gao M , Yan D
Published: October 2020

Background: To solve the problem of medical equipment sharing in clinical emergency rescue between different units in hospital, especially for ventilator. Methods: In the research a self-help ventilator sharing mode based on Internet of Things is introduced, and six special programs for basic security, quality control, clinical operation, disinfection, cost estimation, and health technology assessment are formulated to support the project. Results: An Internet of Things mobile APP is developed, and the running status and real-time location of ventilators can be got and spare ventilators can be shared by Medical stuff themselves on the APP. The 6 special programs are applied to support the self-service ventilator sharing mode. For trial operations of six months, 15 spare ventilators are taken in the pool of shared equipment, which are shared for 16799 hours by 7 clinical units. Conclusions: The self-service of ventilator sharing mode meets the clinical need for equipment for emergency rescue and improves efficiency, which makes a useful exploration for the innovation management for medical equipment by Internet of Things in hospital.
Clinical Application of Intracranial Pressure Monitoring Based on Flash Visual Evoked Potential in Treatment of Patients with Hypertensive Intracerebral Hemorrhage
Authors: Yu Fangping , Zhao Yingchun , Zhang Yu , Luan Xinghua , Wu Ying
Published: October 2020

Objective To investigate the application value of flash visual evoked potential (FVEP) noninvasive intracranial pressure (nICP) monitoring technology in patients with hypertensive intracerebral hemorrhage (HICH).Methods There were 116 eligible subjects included in the experiment, the final sample size was 102 for this study. They were randomly divided into FVEP nICP monitoring group (experimental group) and the non-monitoring group (control group). The experimental group were examined lumbar puncture immediately after intracranial pressure was monitored by FVEP. Mannitol was used in reducing the elevated intracranial pressure. The serum concentrations of creatinine and urea nitrogen were recorded to assess the renal function. To evaluate the efficacy of FVEP nICP monitoring technique for clinical adjustment of mannitol. The Glasgow prognosis scores (GOS) were evaluated for patients' prognosis between two groups.Results There was no statistical significance between FVEP nICP measurement and lumbar puncture intracranial pressure measurement (195.76 ±58.88 mmH2O vs 197.04 ±53.72 mmH2O, P>0.05). Linear correlation analysis indicated that there was a strong positive relationship between the measurements (r=0.950, P<0.01). The duration prescription time and the average usage amount of mannitol in the experimental group was significantly less than that in the control group (P< 0.05), and the serum creatinine and urea nitrogen concentrations in the two groups were not statistically significant (P> 0.05). The cure rate of the experimental group was higher than that of the control group (χ2=3.889, P=0.048).Conclusion FVEP nICP monitoring technology could replace invasive intracranial pressure monitoring technology in part HICH patients. The application of FVEP nICP technique can reduce the dosage of mannitol and improve the prognosis of patients with HICH.
Perception of childbirth experiences of Japanese women in Bali, Indonesia: A qualitative study
Authors: Tanaka Kazuko , Kurniasari Ni Made Dian , Widyanthini Desak Nyoman , Suariyani Ni Luh Putu , Listyowati Rina , Urayama Akimi , Wirawan I Made Ady , Yoshimura Koichi
Published: October 2020

Background: Maternal healthcare services in Indonesia have seen dramatic improvements over the past 25 years and yet there is still room for improvement. The perception, by the women, of the perinatal care provided, is a vital input to further improving these services. This study examines how the perinatal care provided is experienced by Japanese women in Bali, using an interview survey.Methods: We conducted semi-structured interviews, from August to October 2017, with 14 Japanese women living in Badung Regency and Denpasar City in Bali Province, Indonesia to report their perception of the perinatal care they experienced during their pregnancies. The interview guide included among others, the reasons for choosing specific (perinatal care) health facilities and their satisfaction with their experience of using the antenatal, delivery, and postnatal care services. The data were analysed using the qualitative content analysis method.Results: From the interview data, 12 categories across five themes were extracted. Participants reported experiencing various concerns during their pregnancies such as difficulty in obtaining perinatal care related information. From the beginning of their pregnancies, participants gradually established trusting relationships with midwives, but in many situations, they were disappointed with their childbirth experiences, as they felt that the care provided was not woman-centred. Through their own efforts and with the support of family members and other Japanese residents, many women were able to eventually regard their childbirth experiences as positive. Nevertheless, some women could not overcome their negative impressions even years after childbirth.Conclusions: Participants desired close attention and encouragement from nurses and midwives. Our results suggest that Japanese women in Bali expected a woman-centred perinatal care and active support from nursing/midwifery staff during their pregnancies and postnatal care.
Cancer Patient Management Strategy in a Cancer Center of Zhejiang, China During the COVID-19 Pandemic 
Authors: Xu Song-xiao , Cheng Xiang-dong , Pan Zhi-wen , Song Qian , Wang Yi-hong , Xiong Juan , Chen Yong-yi , Fan Fan , Zhu Jing , Wu Wan-ying , Deng Xue-ying , Yu Yan-pin , Xu Xiao-hong , Chen Wen-hu , Zhu Tao , Yu Yang , Liu Kai-zhong , Shao Guo-liang , Chen Ming , Yu En-yan
Published: October 2020

Background: Due to the increased risk of viral infection and the severe shortage of medical resources during the pandemic of COVID-19, most hospitals in the epidemic areas significantly reduced non-emergency admissions and services, if not closed. As a result, it has been difficult to treat cancer patients on time, which adversely affects their prognosis. To address this problem, cancer centers must develop a strategic plan to manage both inpatients and outpatients during the pandemic, provide them with the necessary treatment, and at the same time prevent the spread of the virus among patients, visitors and medical staff. Methods: Based upon the epidemic situation in Zhejiang Province, China, the number of running non-emergency medical wards in the Zhejiang Cancer Hospital was gradually increased in a controlled manner. All staff of the hospital received COVID-19 preventive training and was provided with three different levels of protection according to the risks of their services. Only patients without a known history of SARS-CoV-2 contact were eligible to schedule an appointment. Body temperature was measured on all patients upon their arrival at the hospital. Chest CT image, blood cell counting and travel/contact history were investigated in patients with fever. Respiratory tract samples, such as sputum and throat swabs, from all patients, including those clinically suspected of SARS-CoV-2 infection, were collected for nucleic acid detection of SARS-CoV-2 before treatment.Results: A total of 3697 inpatients and 416 outpatients seeking cancer treatment were enrolled from February 1 to April 3, 2020, in compliance with the hospital’s infection-control interventions. The clinicopathological parameters of the patients were summarized herein. 4237 samples from 4101 patients produced negative RNA testing results. Four clinically suspected patients all presented negative RNA test results and were excluded from the SARS-CoV-2 infection through follow-up retesting and monitoring. Seven patients with only N-gene positive results were retested, followed by CT scan and SARS-CoV-2 contact history investigation. All of them were finally diagnosed as non-infected patients. There was one outpatient who was confirmed positive by virus RNA test and then followed up. She might be an asymptomatic laboratory-confirmed case. During the study period, there was no SARS-CoV-2 infection among staff, patients and escorts of patients in the Zhejiang Cancer Hospital.Conclusion: This study suggested our infection-control interventions, including viral nucleic acid test, could be used as a reliable method to screen cancer patients in the area with moderate COVID-19 prevalence. Cancer may not be a high-risk factor of SARS-CoV-2 infection.
Atraumatic Restorative Treatment compared to the Hall Technique for occluso-proximal carious lesions in primary molars; 36-month follow-up of a randomised control trial in a school setting
Authors: Araujo Mariana Pinheiro , Innes Nicola Patricia , Bonifácio Clarissa Calil , Hesse Daniela , Olegário Isabel Cristina , Mendes Fausto Medeiros , Raggio Daniela Prócida
Published: October 2020

Background: Atraumatic Restorative Treatment (ART) and the Hall Technique (HT) are both minimally invasive, non-aerosol generating procedures (non-AGPs). They seem to have never been directly compared, nor has the HT been studied in a non-clinical setting. This study compared the HT and ART restorations placed in a school setting after 36 months. Methods: Children (5-10 yo) who had a primary molar with an occluso-proximal carious lesion were allocated to the ART or HT arms. Primary outcome: restoration survival over 36-months (using Kaplan-Meier survival analysis, log rank test, and Cox regression). Secondary outcomes: 1) occlusal vertical dimension (OVD) (1, 2, 3, 4 weeks) and 2) child self-reported discomfort; 3) treatment acceptability (immediately following interventions); 4) Child Oral Health Related Quality of Life (OHRQoL), before treatment and after 6 months and 5) a post-hoc analysis of time to tooth exfoliation (1, 6, 12, 18, 24, 30, 36 months). Results: One-hundred and thirty-one children (ART=65; HT=66) were included (mean age=8.1±1.2). At 36 months, 112 (85.5%) children were followed-up. Primary outcome: restoration survival rates ART=32.7% (SE=0.08; 95%CI=0.17-0.47); HT=93.4% (0.05; 0.72-0.99), p<0.001; Secondary outcomes: 1) OVD returned to pre-treatment state within 4 weeks; 2) treatment discomfort was higher for the HT (p=0.018); 3) over 70% of children and parents showed a high acceptability for treatments, with crown aesthetics being a concern for around 23% of parents; 4) Child OHRQoL improved after six months; and 5) teeth treated with the HT exfoliated earlier than those in the ART group (p=0.007). Conclusions: Both ART and the HT were acceptable to child participants and their parents and all parents thought both restorations protected their child’s tooth. However, the crown appearance concerned almost a quarter of parents in the HT arm. Children experienced less discomfort in the ART group. Although both treatments can be performed in a non-clinical setting and have the advantage of being non-aerosol generating procedures (non-AGPs), the HT had almost three times higher survival rates (93.4%) for restoring primary molar occluso-proximal cavities compared to ART (32.7%). 4 Trial registration: This trial was registered in ClinicalTrials.gov (NCT02569047), 5th October 2015. https://clinicaltrials.gov/ct2/show/study/NCT02569047?cond=Hall+Technique+Atraumatic+Rest orative+Treatment&draw=2&rank=2
The risk of new-onset atrial fibrillation in patients with type 2 diabetes mellitus treated with sodium glucose cotransporter 2 inhibitors versus dipeptidyl peptidase-4 inhibitors
Authors: Ling Ann Wan-Chin , Chan Cze-Ci , Chen Shao-Wei , Kao Wei-Yi , Huang Chien-Ying , Chan Yi-Hsin , Chu Pao-Hsien
Published: October 2020

Background: Sodium glucose cotransporter 2 inhibitor (SGLT2i) reduces the risk of hard cardiovascular endpoints in type 2 diabetes mellitus (T2DM) patients with/without established cardiovascular diseases. Whether SGLT2i is associated with a lower risk of new-onset atrial fibrillation (AF) in T2DM patients is unclear. We aimed to evaluate the risk of new-onset AF associated with the use of SGLT2i compared to dipeptidyl peptidase-4 inhibitor (DPP4i) among a longitudinal cohort of diabetic patients. Methods: We used medical data from a multi-center healthcare provider in Taiwan, which included a total of 15,606 and 12,383 patients treated with SGLT2i and DPP4i, respectively, from June 1, 2016 to December 31, 2018. We used propensity-score weighting to balance covariates across study groups. Patients were followed up from the drug index date until the occurrence of new-onset AF, discontinuation of the index drug, or the end of the study period, whichever occurred first. Results: Overall, 55%, 45%, and 0% of the patients were treated with empagliflozin, dapagliflozin, and canagliflozin, respectively. Most patients in the DPP4i group were prescribed with linagliptin (51%), followed by sitagliptin (24%), saxagliptin (13%), vildagliptin (8%) and alogliptin (5%). The use of SGLT2i was associated with a lower risk of new-onset AF compared with DPP4i after propensity-score weighting [hazard ratio: 0.61; 95% confidential interval: 0.50-0.73; P< 0.001]. Subgroup analysis revealed that the use of SGLT2i was associated with a lower risk of new-onset AF compared with DPP4i across several subgroups including old age, female in gender, the presence of cardiovascular disease, hemoglobin A1c 8%, and chronic kidney disease. The advantage of SGLT2i over DPP4i persisted with different SGLT2i (dapagliflozin or empagliflozin) and either low- or standard-dose SGLT2i. Conclusions: SGLT2i was associated with a lower risk of new-onset AF compared with DPP4i among T2DM patients in real-world practice.