bluuebunny/crossref_metadata_2025 huggingface dataset:
PLAN ESTRATÉGICO DE LAS ORGANIZACIONES Y USO DE LAS HERRAMIENTAS DE EVALUACIÓN
Authors: Andrade Vera Silvia Andrea , García Quimis Jilena Jazmín , Cevallos Mieles Ana Pilar , Mera Loor Dexi Janeth , Murillo de la Cruz Cindy Elizabeth
Published: September 2024

El plan estratégico es esencial para que las organizaciones definan sus objetivos, optimicen recursos y establezcan un camino claro hacia sus metas. La planificación estratégica permite anticipar cambios en el entorno, aprovechar oportunidades y mitigar riesgos, proporcionando una guía para la innovación y adaptabilidad. En un entorno empresarial competitivo, contar con herramientas de evaluación adecuadas es crucial para medir el desempeño, identificar áreas de mejora y ajustar estrategias efectivamente.El objetivo principal del estudio fue analizar la implementación y efectividad de las herramientas de evaluación en el proceso de planificación estratégica en diversas organizaciones, identificando mejores prácticas y desafíos comunes en su integración. Se accedió a bases de datos académicas para realizar un análisis comparativo de estrategias y herramientas de evaluación utilizadas por diferentes empresas, identificando patrones y resultados en términos de cuota de mercado, márgenes de beneficio y calidad de productos.
PROCESO ADMINISTRATIVO Y DE TALENTO HUMANO AL GAD MUNICIPAL DEL CANTÓN PAJÁN
Authors: Litardo Rodriguez Israel Alexander , Delgado Gutiérrez Zoila Marianita
Published: September 2024

El estudio proceso administrativo y de talento humano al GAD Municipal del Cantón Paján aborda la problemática de la falta de integración efectiva entre los procesos administrativos y la gestión del talento humano, lo que ha afectado el desempeño y la motivación del personal. El objetivo principal fue analizar cómo el proceso administrativo influye en la gestión del talento humano dentro del GAD para proponer mejoras. La metodología empleada fue de enfoque mixto, aplicando encuestas a 200 funcionarios y realizando una entrevista al director de Talento Humano. Los resultados revelaron que el 60% de los encuestados conoce el proceso administrativo en la selección del personal, mientras que un 55% considera que la planificación es clara y eficiente, aunque un 45% no está de acuerdo. Además, el 75% percibe la comunicación interna como efectiva, y el 75% considera que el proceso de selección es justo y transparente “casi siempre”. En conclusión, aunque el GAD ha avanzado en la alineación de sus políticas con los objetivos estratégicos, persisten desafíos en la percepción de justicia y transparencia en los procesos, así como en la necesidad de mejorar la planificación y comunicación interna.
GESTION DEL TALENTO HUMANO: EMPRESA PÚBLICA DE SERVICIOS DE LA UNIVERSIDAD ESTATAL DEL SUR DE MANABÍ
Authors: Álvarez Pincay Dewis Edwin , Cevallos Garces Paola Estefanía
Published: September 2024

La investigación evidenció la problemática de la falta de un enfoque estratégico en la formación y capacitación del personal, lo cual limita el crecimiento y la eficiencia organizacional. Es por ello que, el objetivo principal fue analizar cómo la gestión del talento humano influye en la formación y capacitación dentro de esta empresa pública, con el fin de mejorar el desarrollo del personal y asegurar la sostenibilidad y competitividad a largo plazo. Se empleó una metodología cualitativa, que permitió una comprensión del tema a través de la entrevista, análisis FODA y revisión documental, enfocándose en los 14 empleados de la EPSU durante 2023. Los resultados indicaron que, aunque la EPSU cuenta con fortalezas como una sólida organización y un entorno laboral competitivo, la ausencia de un plan anual de capacitaciones y la falta de recursos financieros representan desafíos significativos. Finalmente, se concluye que es importante implementar un plan de capacitaciones y mejorar la asignación de recursos para maximizar el potencial de la gestión del talento humano en la organización.
PRESUPUESTO Y CUMPLIMIENTO DE OBJETIVOS ESTRATÉGICOS EN EL GAD VALLE DE LA VIRGEN
Authors: Salazar Pin Ginger Elizabeth , Merchán Hernández Maxy Elizabeth
Published: September 2024

El estudio evidenció la problemática de la dependencia financiera y los trámites administrativos lentos que afectan la ejecución de proyectos estratégicos. En efecto, el objetivo fue analizar cómo la planificación presupuestaria impacta en el logro de los objetivos estratégicos de la institución. La metodología incluyó un enfoque cualitativo con la entrevista, observación directa y análisis FODA, MEFE y MEFI. Los resultados mostraron que, aunque el 70% de las fortalezas, como la participación ciudadana y el personal capacitado, se están aprovechando adecuadamente, solo el 40% de las oportunidades externas se utilizan eficazmente. Las debilidades como la infraestructura insuficiente y las amenazas como las variaciones económicas limitan el desempeño del GAD. En conclusión, es fundamental mejorar la transparencia y la inclusión en la planificación presupuestaria, establecer convenios para diversificar las fuentes de ingresos y fortalecer los mecanismos de monitoreo y control para optimizar la gestión de los recursos.
EVALUACIÓN FINANCIERA Y SU INCIDENCIA EN EL POA DEL GAD PARROQUIAL CAMPOZANO
Authors: Baque Sánchez Erik Raúl , Bravo González Fernando Javier
Published: September 2024

El estudio aborda la problemática de la gestión financiera y su impacto en el cumplimiento del Plan Operativo Anual (POA) del GAD Parroquial Campozano, durante el periodo 2021-2022. El objetivo principal fue determinar cómo la eficiencia financiera influye en el POA, identificando áreas de mejora y proponiendo estrategias de optimización. La metodología empleada fue de carácter no experimental, con un enfoque mixto cualitativo-cuantitativo, utilizando la entrevista y encuestas para recopilar datos directos y documentales. Los resultados revelaron que el 87% de los encuestados considera ineficaz la gestión de los recursos financieros, mientras que solo un 3% la percibe como eficaz. Además, un 84.1% de los participantes está insatisfecho con la distribución de los recursos económicos, aunque el 100% cree que las metas del POA son alcanzables con los recursos asignados. En contraste, el 93% valora positivamente la comunicación de resultados por parte del representante del GAD.
Selected issues of carcinogenesis
Authors: MADEJ JANUSZ A.
Published: September 2024

The types of genetic mutations in the cancer induction of the parent tumor as well as the types and mechanism of cancer metastasis formation were described. These are: 1 – metastases arising from differentiated and undifferentiated cells, step by step through the pre-tumor niche, tumor deposit and metastatic niche, 2 – metastases arising in situ in the tissue from cancer stem cells and 3 – metastases from bone marrow cells „educated” by exosomes according to the horizontal transfer method, taking place without the participation of cells. The development of metastases is not a random process and depends on the expression of adhesin molecules, e.g. on vascular endothelial cells (ICAM-1, VCAM-1). It has been noticed that cancer cells proceed analogously to Darwinian evolution, as DNA damage is preserved and passed on to daughter cells. The relationship between the phenomena of continuous accumulation and Darwinian selection, leading to the constant evolution of cancer, and permanently increasing positive entropy, in accordance with the second law of thermodynamics, was also presented. The lack of effects in the treatment of some cancers may indicate the development of genetically heterogeneous subclones with constant progression, insensitive to treatment.
PROFA. DRA. ANA ROSA KUCINSKI SILVA
Authors: L. A. de Faria Dalva
Published: September 2024

DR ANA ROSA KUCINSKI SILVA. Ana Rosa Kucinski Silva, lecturer in the Department of Chemistry at the University of São Paulo (São Paulo, Brazil), had her academic career violently interrupted in April 1974 when was kidnapped, tortured, and murdered by the repression forces of the military dictatorship (1964-1985). Since then, papers and books were written about her, emphasizing her political activities but much less is known on her academic activities. Fifty years after her disappearance, this work aims to contribute to fill this gap.
Determination of Lisdexamfetamine in Human Plasma by LC-MS/MS Method
Authors: A. R. Silva Alex , L. D. Coelho Lilia , Y. Sánchez-Luquez Karen , H. D. Garcia Pedro , Boldin Renata , M. R. Silveira Anne , A. Antonio Marcia , M. Porcari Andreia , O. Carvalho Patrícia
Published: September 2024

Lisdexamfetamine is a prodrug that is converted to d-amphetamine in the body, mainly used to treat attention deficit hyperactivity disorder in children and adults. Its mechanism involves the enhancement of neurotransmitters such as norepinephrine and dopamine, which are critical for attention and behavioral regulation. With the upcoming patent expiration of Vyvanse®, bioanalytical methods for the quantification of lisdexamfetamine in plasma are needed for use in pharmacokinetic studies. In this work, we developed and validated a sensitive bioanalytical method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for lisdexamfetamine quantification in human plasma. The method developed was performed for 4 min per sample and using the concentration range of 0.3-100 ng mL-1. Intra-batch, inter-batch and instrument reproducibility, the precision was lower than 10%. The results demonstrated that the method is rapid, sensitive, robust, and suitable for pharmacokinetic studies.
Troops of Rus’ in the Mongol Army
Authors:   St. Petersburg State University, Maiorov Alexander V.
Published: September 2024

Creating a world empire, Chinggis Khan and his heirs developed mechanisms of mobilization that made it possible to satisfy the growing needs for material and human resources necessary for this grandiose enterprise. The recruitment of foreign specialists and, in particular, experienced military leaders became a constant practice of the Mongols. Its numerous traces are recorded both in the east and in the west of Eurasia, including Eastern Europe and Rus’. The Mongols mobilized combat-capable men among all conquered or subjugated peoples, both nomadic and sedentary, for the formation of shock units of their army used in the most dangerous areas of hostilities. Rus' chronicles do not contain information about the mobilization of inhabitants of Rus' lands and cities into the Mongol army. Rus' sources also contain no information about the participation of the auxiliary troops of Rus' on the side of the Mongols during the Great Western Campaign. However, such information is provided by Western Latin-language sources, including those synchronous with the Mongol invasion of Poland and Hungary and originating from the territory of these countries. The reports of Rogerius of Apulia and Thomas of Split, as well as the later account of Jan Długosz, corroborate each other. They are also confirmed by the testimony of other sources from the mid-thirteen century. Along with the Cumans, the Russians undoubtedly formed a significant part of the auxiliary contingents, which in their total strength were comparable to or even exceeded the size of the main Mongol armies.
The Chronicle of Nestor in the Early Slovak Historiography
Authors:   Comenius University Bratislava, Daniš Miroslav
Published: September 2024

The study deals with the early Slovak historiography which referred to the Russian chronicles as one of the sources to understand the development of the early Slavic history. This chronicle also contributed to the creation of the historical concept of the modern Slovak nation at the end of the 18th century and in the 19th century. The chronicle of Nestor is a valuable source of knowledge and information for the earliest history of Russia, Belarus, Ukraine; for the history of the Slavs; ecclesiastical history; and medieval European history in general. As far as the national history of the Slovaks is concerned, this chronicle is perhaps the most detailed description of the events with regards to the arrival of the saints Constantine and Methodius in Great Moravia. It details their prolific activity, their influence on the development of the Slovak literature and the integration of Great Moravian Slavs into the family of civilized European cultures with their national, linguistic, and Christian core. In the context of the emergence of the Slovak historiography and during the period of the national revival of the Slovaks in the 19th century, the chronicle of Nestor became an important source of scholarly arguments against the Hungarian historical scholarship in particular. In the first half of the 20th century, the study of Nestor’s chronicle was primarily the work of two Russian scholars-emigrants, working in Slovakia — the linguist V. Pogorelov and historian E. Perfetski. Post-war and contemporary Slovak science (especially history and linguistics) approaches the issue of Russian chronicles and the chronicle of Nestor mainly in the context of the interpretation of the old Slavic and Slovak history and literature.
Assessment of land use and land cover changes on hydrological responses in the Wadi Soummam watershed, Algeria using the HEC–HMS model
Authors: Abdelkebir Brahim , Mokhtari Elhadj , Engel Bernard
Published: September 2024

This study aims to predict land use and land cover (LULC) changes for the years 2030 and 2050 using Markov models, and subsequently assess the impacts of these changes on water resources in the Wadi Soummam watershed, Algeria, employing the HEC–HMS model. The research compares five LULC maps (2005, 2015, 2020, 2030, and 2050) to identify variations over the years. The results indicate a notable increase in urbanization, accompanied by a reduction in agricultural and forested areas, leading to a decline in overall vegetation cover. Forests and grasslands experienced a consistent decrease between 2020 and 2050, while urban areas expanded. These LULC alterations have significant implications for the water resources in the study area. From 2030 to 2050, the average annual water yield witnessed an increase of 38.6 m3/s for the 10-year return period event and 70.8 m3/s for the 100-year return period event. Conversely, peak flows exhibited a decline for various return periods between 2005 and 2015, followed by an increase from 2015 to 2020 due to the impact of LULC changes. For instance, the peak flow for the 10-year return period in 2005 was 1651.1m3/s, which decreased to 1604.5 m3/s in 2015, but rose to 1632.8 m3/s in 2020.
ESTILO DE VIDA SAUDÁVEL COMO FATOR PREVENTIVO DA DOENÇA DE ALZHEIMER: REVISÃO INTEGRATIVA
Authors: Lira Giovanna Geslley de Oliveira , Mariz Kalline  Marcelino da Silva , Freire Luana Lumilla Gurgel , Candeia Vithoria Silvestre , Guedes Giovanna Beatriz de Oliveira , Sousa Milena Nunes Alves de
Published: September 2024

Introdução: A doença de Alzheimer caracteriza-se como uma doença gradativa e sua evolução é influenciada por inúmeros fatores como: idade avançada, diabetes mellitus, obesidade, tabagismo, dieta inadequada, sedentarismo e depressão. Objetivo: Identificar os fatores de risco que contribuem na prevenção da Doença de Alzheimer (DA) e sua relação com um estilo de vida saudável. Metodologia: O presente estudo se refere a uma Revisão Integrativa de Literatura e a busca foi feita em base de dados nacionais e internacionais. A partir dos Descritores em Ciências da Saúde (DeCS) em inglês e definida a utilização de operadores booleanos (AND) e (OR)- "HealthyLifestyle" AND "Alzheimer Disease" AND "Primary Prevention" OR "DiseasePrevention" AND "NeurodegenerativeDiseases" AND "Neurology" - nas bases de dados National Library of Medicine, Biblioteca Virtual em Saúde (BVS), ScientificElectronic Library Online; BioMed Central e Portal de Periódicos da Coordenação de Aperfeiçoamento de Pessoal de Nível Superior. Resultados: Os resultados revelaram que de 13 artigos selecionados para caracterização geral, quase a metade foi classificada em estudo de revisão sistemática. O ano de maior prevalência foi o de 2022 e o idioma de maior prevalência foi a língua inglesa. Conclusões: Ademais, uma alimentação equilibrada com o consumo de frutas, vegetais, legumes e nozes, foi relacionada com uma diminuição nas probabilidades da DA. Observou-se que existem relações com fatores multivariados que podem prevenir ou desencadear a condição clínica.
Palavras-Chave: Demência; Hábitos Saudáveis; Fatores de Risco.
AS CONDIÇÕES CLÍNICAS DE MULHERES COM DIABETES TIPO 2: AVALIANDO PARA PREVENIR AGRAVOS
Authors: Medeiros Mateus Marinho , Medeiros Lis Cardoso Marinho , Eulálio Kelsen Dantas , Silva Nayana Duarte da , Silva Jardeson José da Rocha , Silva Zenira Martins
Published: September 2024

Introdução: O diabetes mellitus (DM) é uma doença metabólica caracterizada pelo controle inadequado dos níveis de glicose no sangue, principalmente um estado crônico de hiperglicemia, causado por diferentes processos patogênicos, levando a  complicações do sistema nervoso do DM incluem axonopatias, doenças neurodegenerativas, doenças neurovasculares e comprometimento cognitivo geral. Objetivo: Avaliar as complicações clínicas da diabetes tipo 2 em mulheres. Metodologia: Tratou-se de um transversal, do tipo prevalência. Foram usados dois grupos de mulheres, onde todas as mulheres estavam com diagnóstico de diabetes Tipo 2 e idade de 40 e 60 anos, com o tratamento oral -G1 e com tratamento com insulinoterapia – G2, ambos fornecidos pela rede pública (SUS). Para comparação das variáveis estudadas foi utilizado o método de Mann-Whintney, adotando-se o nível de significância menor que 5% (p, valor ,0,05). Resultados: A proporção de pessoas com diabetes no Piauí, com consulta e hemoglobina glicada solicitada no primeiro quadrimestre de 2021, 2022, 2023, foi de 18, 16 e 34 percentuais, respectivamente e em Boa Hora nos mesmos quadrimestres foi 36, 39, 56 percentuais, respectivamente. Os procedimentos hospitalares do SUS - por local de residência - Piauí foi de um total de 1.193 e em Boa Hora 24. O grupo de mulheres estudadas mostrou uma diferença significativa para a glicemia em jejum e a Hemoglobina glicada quando comparados os grupos G1 e G2. Quase 100% da amostra estava obesa (IMC > 25), não fumava e não praticava atividade física. Conclusões: Concluiu-se que a as pacientes tiveram um agravamento do adoecimento ao longo dos anos com aumento de medicação. A ausência das boas práticas de promoção de saúde, atividade física e alimentação, podem ter contribuído com o agravamento. Outrossim há necessidade urgente de uma intervenção para mudança de hábitos na população para que a medicalização seja diminuída para a promoção da saúde.
Natural and Synthetic Capsaicin Analogues: A Comprehensive Review of Biological Effects and Synthetic Pathways
Authors: Gimenez Borges Lara , Nascimento de Oliveira Alves Thais , Vassiliades Sandra Valeria , Parise-Filho Roberto
Published: September 2024

Capsaicin analogs, whether sourced from natural origins or synthesized de novo,
have garnered significant attention across diverse scientific disciplines. This comprehensive
investigation explores the expansive domain of medicinal chemistry and pharmacology,
focusing on capsaicin and its analogs. Notably, these analogs exhibit a wideranging
pharmacological spectrum, with a particular emphasis on their potent antitumor
properties. Researchers frequently explore structural modifications, particularly in region
C, consistently enhancing their pharmacological activities. A highlighted finding is that
analogs with alterations in both regions A and C manifest a diverse array of effects, spanning
from anti-obesity to protection against ischemia. They also demonstrate anti-
Alzheimer's, anti-fibrotic, anti-inflammatory, anti-diabetic, antimalarial, and anti-epileptic
properties. This underscores the potential of structural adaptations in these regions, expanding
the therapeutic applications of capsaicin-like compounds. Additionally, manipulations
in regions B and C result in compounds that possess antioxidant and anti-obesity
properties, providing valuable insights for the development of novel compounds. The
therapeutic potential of capsaicin analogs opens innovative avenues for drug design and
development, promising to address a broad spectrum of diseases and enhance global
quality of life. Moreover, this article meticulously examines various synthetic methodologies
for synthesizing capsaicin analogs, complementing the main review. These methodologies
distinguish themselves through their simplicity, mild reaction conditions, and reliance
on readily available commercial reagents. The accessible synthesis pathways enable
researchers from diverse backgrounds to explore these compounds, fostering investigations
and potential therapeutic applications.
FN-1501 Inhibits Diffuse Large B-Cell Lymphoma Tumor Growth by Inducing Cell Cycle Arrest and Apoptosis
Authors: Zou Dan , Hu Bowen , Feng Sitong , Si Rujia , Zhong Bei , Shen Bo , Du Yuxin , Feng Jifeng
Published: September 2024

Background:

Due to its high degree of aggressiveness, diffuse large B-cell lymphoma (DLBCL) presents
a treatment challenge because 30% to 50% of patients experience resistance or relapse following standard
chemotherapy. FN-1501 is an effective inhibitor of cyclin-dependent kinases and Fms-like receptor tyrosine
kinase 3.

Objective:

This study aimed to examine the anti-tumor impact of FN-1501 on DLBCL and clarify its molecular
mechanism.

Methods:

This study used the cell counting kit-8 assay to evaluate cell proliferation, along with western blotting
and flow cytometry to analyze cell cycle progression and apoptosis influenced by FN-1501 in vitro. Afterward,
the effectiveness of FN-1501 was evaluated in vivo utilizing the xenograft tumor model. In addition, we identified
the potential signaling pathways and performed rescue studies using western blotting and flow cytometry.

Results:

We found that FN-1501 inhibited cell proliferation and induced cell cycle arrest and apoptosis in
DLBCL cells in vitro. Its anti-proliferative effects were shown to be time- and dose-dependent. The effect on cell
cycle progression resulted in G1/S phase arrest, and the apoptosis induction was found to be caspase-dependent.
FN-1501 treatment also reduced tumor volumes and weights and was associated with a prolonged progressionfree
survival in vivo. Mechanistically, the MAPK and PI3K/AKT/mTOR pathways were significantly inhibited by
FN-1501. Additional pathway inhibitors examination reinforced that FN-1501 may regulate cell cycle arrest and
apoptosis through these pathways.

Conclusion:

FN-1501 shows promising anti-tumor activity against DLBCL in vivo and in vitro, suggesting its
potential as a new therapeutic option for patients with refractory or relapsed DLBCL.
Role of Dinacharya to maintain Circadian Rhythm for Cell Rejuvenation - A Review
Authors: Pradeep V. Mishrikoti  , Prarthana HM  , Tukaram Lamani
Published: September 2024

In this era, people want to stay healthy and live long lives. To achieve this, they should follow proper Dinacharya, Nishicharya, and a proper diet. Those who follow Dinacharya can stay healthy and strong. Dinacharya is a concept in Ayurveda, explained by different Acharyas. It helps achieve Swastya by maintaining the body’s circadian rhythm, controlled by the hypothalamus, and regulating biological rhythms. Dinacharya includes practices such as Prathakalottana, Danta Dhavana, Jivha Nirlekhana, Abyanga, Nasya, Anjana, Vyayama, and more. Circadian rhythm is a physiological function regulated by the brain, typically on a 24-hour cycle. Those who follow proper Dinacharya maintain a healthy circadian rhythm and live healthier lives without disease. Although aging is a natural process that cannot be stopped, it can be slowed down. Ayurveda offers concepts like Rasayana, Abhyanga, and Udvartana to delay early aging. Modern science also supports therapeutic massage for cell rejuvenation. On this earth the person will grow and become aged. Ageing is a natural process which cannot be stopped but it can be slow downed. To achieve this our Acharyas have explained some of the concepts. By following these we can achieve delay of early ageing.
Critical review of efficacy of Pushyanug Churna in Raktapradara
Authors: Pratima Shikerkar  , Gandhali Upadhye
Published: September 2024

Aptopadesha is one of the Pramana accepted in Ayurveda. Many of the times physician may not be knowing the mode of action of certain Dravyas in clinical practice but they are used frequently in treating the patients and they also give very good results. Here the attempt is made to study the efficacy of Pushyanug Churna in Raktapradara (Abnormal menstrual bleeding), a common and serious etiological condition in females.
Role of Kleda in Kushta (Skin Diseases) - A Review Article
Authors: Srinidhi Shetty  , Prabhjot Kaur  , Surekha Kamath  , Rashmi Bairwa  , Surendra K Sharma
Published: September 2024

The human body's outermost layer skin, shields interior organs and tissues. Skin disorders account for 1.79% of the world's total illness burden.[1] The majority of the time, skin disorders are the external manifestations of underlying systemic disorders. Modern dermatological treatment strives to relieve symptoms and achieve a long-lasting remission, but Ayurveda seeks to cure patients completely by identifying and treating the underlying causes of their skin disorders. In Ayurveda, skin conditions fall mostly under the category of Kushta. The seven important components that Ayurveda believes are involved in the pathophysiology of Kushta are referred to as Saptako Dravyasangraha. It consists of Tridosha, Tvak, Mamsa, Rakta and Ambu/Lasika (body fluids).[2] The Ambu described here is likewise a Kleda, signifying Ap Mahabhuta in the body.[3] The goal of the current work is to emphasize Kleda's function in Kushta and how treating Kleda can aid in the treatment of skin conditions.
A review on Aplap Marma and Apastambha Marma
Authors: Snehal R Bisen  , Diksha R Kapgate  , Gopal B Sharma
Published: September 2024

Ayurveda is a science of mental, physical and spiritual well-being. Marmas is one of the most important concepts of Ayurveda. According to some Acharyas, Marmas are defined as the anatomical places where Mansa, Sira, Snayu, Asthi, Sandhi meet together. Total number of Marma’s is 107. Out of these Aplap and Apastambha Marma are considered as a Madhyasharirgata Marma (Urogata Marma). According to effect both are Kalantar Pranhar Marma and 2 in numbers. In this article an attempt is made to highlight the Anatomy, Position and Importance of Aplap and Apastambha Marma with its Viddha Lakshanas given in the Ayurveda literature.
Phytoestrogens: Unlocking the Power of Plant Based Estrogens
Authors: Shanmugaloga S  , Shilpa P N
Published: September 2024

Phytoestrogens, naturally occurring plant compounds with estrogen-like activity, have garnered significant attention for their potential health benefits in both males and females. These compounds, found in a variety of foods such as soybeans, flaxseeds, and whole grains, mimic the action of estrogen in the body by binding to estrogen receptors. In females, phytoestrogens have been particularly noted for their role in alleviating menopausal symptoms. They can help reduce hot flashes, night sweats, and vaginal dryness, offering a natural alternative to hormone replacement therapy (HRT). Furthermore, phytoestrogens have been linked to a reduced risk of osteoporosis by promoting bone health and improving bone density, crucial for postmenopausal women. Males also benefit significantly from phytoestrogens. Studies suggest that these compounds can help maintain prostate health and reduce the risk of prostate cancer by inhibiting the growth of cancer cells. Additionally, phytoestrogens have been associated with improved cardiovascular health in both genders. They contribute to lowering cholesterol levels and improving arterial function, thereby reducing the risk of heart disease. Beyond these benefits, phytoestrogens possess potent antioxidant and anti-inflammatory properties, enhancing overall immune function and potentially offering protective effects against certain chronic diseases such as diabetes and obesity. Their ability to modulate hormone levels without significant side effects makes them a promising component of a balanced diet for long-term health maintenance. This study attempts to compile foods high in phytoestrogens and herbs used in Ayurvedic medicine with its super benefits.
A critical review of Prana Vayu and its correlation with contemporary science
Authors: Twinkal Pramar  , Ashok Kumar Sharma  , Rekh Raj Meena  , Komal Chavda
Published: September 2024

Tridosha Siddhanta stands high as Vata, Pitta and Kapha are the three biological humors, present in the bodies which are responsible for the maintenance of homeostasis. Vata dosha is the most important factor of Tridosha which is responsible for controlling all types of movements. Prana Vayu, one of the five Vata Doshas, travels via the Urah (thorax region) and Kantha (throat region) from its location in the head. It is reasonable for the processes of respiration, deglutition, eructation, sneezing, and spitting. It also keeps the heart, Hridaya (intelligence/judgment), and Chitta (mind) functioning properly. Hearing head refers to the brain and brain stem, which are in charge of all these processes. According to modern medical research, Prana Vayu performs all of the same roles. In general, the Prana Vata's functions can be related to those of the limbic system, cranial nerves, cerebral cortex, basal ganglia, and other components. Thus, it is easy for us to understand the fundamentals of Ayurveda, which is desperately needed in the modern world. In modern medicine, the majority of the Vatika illnesses treated in Ayurveda are classified as neurological disorders. There aren't many published publications on the intellectual aspects of Vata. An attempt has been made in this article to correlate the physiological activities of Prana Vayu, with a focus on neurophysiology.
A critical review of Millets with special reference to Ayurveda
Authors: Vijay Kannoj  , Tarendra Singh Songara  , Urmila Shukla  , Sharad Rathi
Published: September 2024

Millets are a traditional staple food of the dry land regions of the world. In India, millets are grown on about 17 million hectares with annual production of 18 million tones and it contributes 10 percent to the country’s food grain basket. In a visionary move the government of India proposed to united nation to designed 2023 as the international year of millets as 72 countries rallied behind the passes the UN general assembly recognized 2023 as the year to celebrate this humble grains. The available cultivable plant‐based food resources in developing tropical countries are inadequate to supply proteins for both human and animals. Millets are an important food crop at a global level with a significant economic impact on developing countries, Millets are considered as high‐energy yielding nourishing foods which help in addressing malnutrition. Grains of these millet species are widely consumed as a source of traditional medicines and important food to preserve health. Choosing millets as part of diet is a small step with a big impact these grain often overlooked contribute to personal health and environmental sustainability. Rich in nutrients, gluten-free and resilient in diverse climates, millets offer a sustainable alternative that can make a significant difference in both individual well-being and global food systems.
Theory on Raseshwara Darshana
Authors: Ashwini Chandaragi  , Malavi Shayan  , Vikram S.
Published: September 2024

Ayurveda is closely related to Indian philosophy, particularly the spirit of Darshana. Rasashastra features a unique philosophical system known as Raseshwara Darshana. This philosophy differs from other Darshanas in that, while all three Darshanas generally believe that Mukti (liberation) is achieved only after death or through Samadhi (meditative absorption), Raseshwara Darshana does not accept this concept. Instead, Raseshwara Darshana holds that Mukti can be attained while still alive by achieving Pindastairyam through the practice of Paradaseva. Parada, considered the best Rasayana (rejuvenative), is believed to increase life longevity. However, since the body cannot tolerate excessive Parada in its raw form, it must undergo appropriate Samskara (purification) to make it suitable for use.
Role of Ayurveda in the Conservative Management of Avascular Necrosis of Femur Head - A Case Report
Authors: Merlyn T Jones  , Vasantha B  , Muttappa Totad  , Amarnath BR
Published: September 2024

Avascular necrosis describes the death of bone due to impairment of its blood supply. Non-traumatic or idiopathic osteonecrosis is thought to be the result of an ischemic episode affecting the bone and marrow tissue and may cause a progressive collapse of the femoral head in adults. Treatment is usually surgical and is determined by the stage and extent of the disease. Here is the case of a 36-year-old female who was diagnosed with avascular necrosis one and half years ago and was admitted with chief complaints of severe pain, stiffness in the left hip with radiating pain from left hip to lower limb and occasional pain in right hip. She was given Ksheera Vaitarana Basti and oral medications for period of 12 days. After the treatment pain, stiffness in left hip has reduced and gait was improved. This case shows that Ayurveda treatment is helpful in the management of avascular necrosis and helps in improving the quality of life.
Ayurvedic management of Kampvata - A Case Study
Authors: Hanika Sharma  , Deepu Tiwari  , Poonam Gupta
Published: September 2024

Ayurveda is the everlasting supreme science of medicine because it deals with every aspects of life, particularly of human being since time immemorial. The Vata which is the motivator and controller of other two Dosha are responsible for the manifestation of almost all diseases. According to Ayurveda most of the diseases of Vata are degenerative disorders of nervous system. 80 types of Vataja Nanatmaja Vikaras are described in Ayurveda texts. Kampavata as one among them manifests with Dehabhramana (postural instability), Karapada Tale Kampa (tremors in hands and legs), Matiksheena (dementia), and Nidrabhanga (sleeplessness). Based on sign and symptoms, Kamvata can be correlated with Parkinson’s disease. The Parkinson’s disease is a progressive neurological disorder. This disease affects approximately 2 out of 1000 people, and most often develops after age of fifty, the clinical course is chronic and progressive with severe disability attained after approximately ten years Parkinson's disease is a progressive nervous system disorder that causes motor symptoms like rigidity, bradykinesia, tremors, and impaired balance. It is caused by degeneration of dopamine-producing neurons in the brain. Physical therapy focuses on improving motor skills through exercises to enhance flexibility, strength, balance, gait, and cardiovascular fitness. Treatment involves both pharmacological interventions and physical therapy techniques like cueing, relaxation exercises, and functional training. The goals are to reduce symptoms, improve mobility and quality of life, and help patients better manage their condition.
Comparative characterization study of Loha Bhasma and Triphala derived Iron Nano Particles
Authors: Gururaja D.
Published: September 2024

Character of a particle varies as size changes from macro to nano scale. Size of the particle is of great value in the field of medicine. Size has the influence on dosage, delivery and penetration of the medicine. Rasashastra is the branch which deals with the use of minerals and ores for health benefit. Bhasma is the unique preparation which is very minute in nature intended to penetrate deep into the tissues with minimal dosage. Nano medicine is the recent develop in the field of medicine where nano particles are used to reach the target cells. Nano particles are synthesised by different methods. Green synthesis is the method where herbal extracts were used to synthesize the nano particle. This method is similar to preparation of Bhasma where different herbs are used. In this study Iron nano particles were synthesized using Triphala extract and it is compared with Loha Bhasma. Bhasma Pareeksha and Characterization studies were done. This study confirms the nano nature of Bhasma and similarity in the structure between Bhasma and Nano particles.
Pengaruh Peran Account Representative, Insentif Pajak Dan Pemeriksaan Pajak Terhadap Penerimaan Pajak Di Masa Pandemi Covid-19
Authors: Mohammad Khoiru Rusydi  , Utami Agianti Diskaveria
Published: September 2024

This research aims to determine and verify the effect of account representative role, tax incentive, and tax audit on tax revenue during the COVID-19 pandemic, employing a quantitative approach incorporating secondary data from the Small Taxpayers Office on e-Riset official website authorized by the Directorate General of Taxes. This research includes 96 samples taken from four small Taxpayer offices during 2020-2021, selected through a purposive sampling method with specified criteria, and analyzed using multiple linear regression (MLR) utilizing SPSS version 26.0. The results indicated that the account representative role had no effect. In contrast, the tax incentive and tax audit had a positive and negative impact on the tax revenue during the COVID-19 pandemic, respectively.
Abstrak
Penelitian ini bertujuan mengetahui dan membuktikan pengaruh peran account representative, insentif pajak, dan pemeriksaan pajak terhadap penerimaan pajak di masa pandemi COVID-19. Jenis penelitian ini adalah penelitian kuantitatif dengan data-data sekunder dari Kantor Pelayanan Pajak Pratama yang telah diberikan izin oleh Direktorat Jenderal Pajak melalui situs web resmi e-Riset. Pengambilan sampel dilakukan dengan metode purposive sampling dengan kriteria yang ditentukan menghasilan 96 sampel yang diambil dari 4 Kantor Pelayanan Pajak Pratama selama tahun 2020-2021. Metode analisis data yang digunakan adalah analisis regresi linear berganda dengan menggunakan program SPSS versi 26 sebagai alat bantu analisis data. Hasil penelitian membuktikan bahwa peran account representative tidak berpengaruh terhadap penerimaan pajak di masa pandemi covid-19, sedangkan insentif pajak berpengaruh positif dan pemeriksaan pajak berpengaruh negatif terhadap penerimaan pajak di masa pandemi covid-19.
Detection of the TYR Gene as a Candidate Causal Mutation for Albinism in Taro Cattle
Authors: Reza Muhammad Aulia , Noor Ronny Rachman , Jakaria Jakaria , Margawati Endang Tri
Published: September 2024

Bali Cattle are known as cattle with a unique coat color pattern. At Taro village was found different coat colors of Bali cattle, namely Taro cattle perform white coat color. The TYR gene has a vital role in producing coat color. This research was aimed to determine mutations that caused of the white color in Taro cattle. Two methods of PCR and PCR-RFLP were applied in this study. PCR method followed by sequencing used 29 DNA samples consisted of 17 Taro cattle, 12 DNA samples of 3 breeds cattle as comparison while RFLP method applied 56 DNA samples (17 Taro; 31 wild Bali; 4 Simental, 4 PO/Ongole descendant). All DNA were collected from fresh blood, and extracted by using DNA Extraction Kit. Amplification of TYR (exon 5) gene was conducted using forward and reverse primers to get polymerase chain reaction products with lengths of 320 bp and sequenced with Sanger method (services). PCR-RFLP was conducted with enzyme restriction of AciI. Determination of TYR gene diversity was analyzed through sequencing data. TYR gene sequencing was analyzed by using Bioedit and Mega11 software to identify single nucleotide polymorphisms (SNPs). SNP genotyping was analyzed from PCR-RFLP. The results showed that the TYR gene (exon 5) of Taro cattle was found with 320 bp length. SNP was obtained at one position c.1467 T>C. This SNP has never been reported yet on the ensemble website. This finding suggests that a specific genetic marker for albinism in Bali cattle needs to be more explored
Identification of Market Demand for Omega-3 Eggs in Bogor Regency
Authors: Soesanto Iman Rahayu Hidayati , Yani Ahmad , Tanti Ariyani
Published: September 2024

The egg market is a crucial sector in the food industry. Eggs are not only an affordable and highly nutritious source of protein but also offer nutritional variations that can be tailored to consumer needs. Increasingly knowledgeable consumers and easily accessible information have opened new opportunities for the development of innovative food products that meet public health needs. One such product is omega-3-enriched eggs. This study aimed to identify the demand for omega-3 eggs in Bogor Regency. The survey method was used from August 22-23, 2023. The survey results indicate that most consumers are willing to purchase omega-3 eggs in large quantities, with 50% of respondents willing to pay Rp. 3000 per egg. These findings reflect high interest in increasing omega-3 fatty acid intake through accessible products. Furthermore, 37% of respondents often shop for eggs at supermarkets, indicating a significant opportunity for product placement in major retail stores. Practical packaging with plastic mica was also preferred by 70% of respondents due to its practicality and efficiency. Thus, omega-3 eggs can be developed in Bogor Regency because they meet market needs and offer promising business opportunities.
Crónica do Tribunal da Relação de Guimarães
Authors: Ribeiro Vinício
Published: September 2024

II – Jurisprudência da Secção Criminal
Focus. Bronteksten van de Synode van Dordrecht 1618-1619
Authors: Moehn W.H.Th.
Published: September 2024

N.a.v.: Donald Sinnema, Christian Moser en Herman J. Selderhuis (red.), Acta of the Synod of Dordt [Acta et Documenta Synodi Nationalis Dordrechtanae (1618-1619), 1 (ADSND)] (Göttingen: Vandenhoeck & Ruprecht, 2015) cvii + 539 p., € 225,00 (ISBN 9783525550786); Donald Sinnema, Christian Moser, Erik A. de Boer en Herman J. Selderhuis (red.), The Convening of the Synod of Dordt [ADSND 2,1] (Göttingen: Vandenhoeck & Ruprecht, 2023) lxiii + 808 p., € 250,00 (ISBN 9783525554661); Donald Sinnema, Christian Moser en Herman J. Selderhuis (red.), Early Sessions of the Synod of Dordt [ADSND 2,2] (Göttingen: Vandenhoeck & Ruprecht, 2018) xliii + 961 p., € 225,00 (ISBN 9783525570548).
PREFERENSI KONSUMEN DALAM MENGONSUMSI MASAKAN PADANG DI KOTA YOGYAKARTA DITINJAU DARI FAKTOR INDIVIDU, LINGKUNGAN, DAN KARAKTERISTIK MAKANAN
Authors: Sijabat Michael Sakti , Rinawati Wika
Published: September 2024

Penelitian ini bertujuan untuk mengetahui: (1) preferensi konsumen dalam mengonsumsi masakan Padang ditinjau dari faktor individu, (2) faktor lingkungan (3) faktor karakteristik makanan dan (4) jenis masakan Padang yang paling disukai hingga kurang disukai oleh konsumen. Jenis penelitian yang digunakan adalah deskriptif kuantitatif dengan metode survei dan menyebarkan kuesioner. Penelitian dilaksanakan di 3 rumah makan Padang yaitu: “Padang Murah”, “Kawan Lamo” dan “Sabana Murah”. Teknik pengambilan sampel adalah purposive sampling dengan jumlah responden sebanyak 75 konsumen. Teknik analisis data yang digunakan adalah analisis deskriptif. Hasil penelitian menunjukkan bahwa: (1) preferensi konsumen dalam mengonsumsi masakan Padang di kota Yogyakarta ditinjau dari faktor individu mayoritas dipengaruhi oleh aspek fisiologis, (2) faktor lingkungan mayoritas dipengaruhi oleh aspek budaya, (3) faktor karakteristik makanan mayoritas dipengaruhi oleh warna, aroma, rasa, dan secara keseluruhan, dan (4) jenis masakan Padang yang paling disukai adalah ayam bakar dan yang paling kurang disukai adalah gulai ikan.
PENGEMBANGAN VIDEO ANIMASI PERHITUNGAN INFORMASI NILAI GIZI UNTUK SISWA SMK AGRIBISNIS PENGOLAHAN HASIL PERTANIAN
Authors: Ariyanto Fikri , Anggraeni Andian Ari
Published: September 2024

Tujuan penelitian ini adalah mengembangkan dan mengevaluasi kelayakan video whiteboard animation yang menjelaskan perhitungan informasi nilai gizi. Penelitian ini menggunakan metode R&D (Research and Development) dengan model pengembangan 4D (define, design, development, disseminate). Tahap pertama adalah define, yang melibatkan analisis masalah, peserta didik, kurikulum, dan materi. Tahap design melibatkan penyusunan materi, storyboard, naskah video, gambar animasi, dan pembentukan tim produksi. Developmentadalah tahap produksi media dan validasi oleh ahli media dan materi. Disseminate adalah tahap penyebaran terbuka berupa pengunggahan video ke YouTube. Produksi video berkembang dinamis, dibatasi oleh biaya, tenaga, dan waktu, sehingga perlu dilakukan validasi kelayakan lagi oleh pengguna. Hasil penelitian mencakup: 1) Video berdurasi 12 menit 54 detik yang membahas informasi nilai gizi dan perhitungan nilai gizi. Video diunggah di kanal YouTube Boga UNY. 2) Hasil penilaian menunjukkan tingkat kelayakan tinggi, dengan nilai 95,56% oleh ahli media dan 96,89% oleh ahli materi. Penilaian pengguna menunjukkan hasil 90,05% oleh 30 siswa dari kelas XII Agribisnis Pengolahan Hasil Pertanian SMK N 1 Pandak. Video ini dianggap masih sangat layak digunakan sebagai media pembelajaran, sehingga belum diperlukan produksi ulang.
PENGARUH PERSEPSI BRAND IMAGE DAN PERSEPSI HARGA TERHADAP KEPUTUSAN PEMBELIAN PADA PESAN ANTAR MAKANAN ONLINE
Authors: Rahmawati Dini Ayu , Komariah Kokom
Published: September 2024

Penelitian ini bertujuan untuk mengetahui: (1) persepsi konsumen terhadap brand imagepada pesan antar makanan online; (2) persepsi konsumen terhadap harga pada pesan antar makananonline; (3) tingkat keputusan pembelian konsumen pada pesan antar makanan online; (4) pengaruhpersepsi brand image terhadap keputusan pembelian pesan antar makanan online; (5) pengaruhpersepsi harga terhadap keputusan pembelian pesan antar makanan online; (6) pengaruh persepsibrand image dan persepsi harga terhadap keputusan pembelian pesan antar makanan online. Jenispenelitian ini termasuk deskriptif kuantitatif yang menggunakan teknik survei. Populasi padapenelitian ini adalah mahasiswa di Fakultas Teknik Universitas Negeri Yogyakarta yang berjumlah5.098. Besaran sampel ditentukan menggunakan Rumus Slovin diperoleh 100 partisipan dimanapengambilan sampelnya menggunakan accidental sampling. Instrumen penelitian menggunakankuesioner tertutup (google form) dengan skala likert (skala 1-4) yang diuji validitas dan reliabilitas.Teknik analisis data menggunakan analisis deskriptif dan regresi linear berganda dengan uji analisisprasyarat, meliputi uji normalitas, uji linearitas, uji multikolinearitas, dan uji heteroskedastisitas. Hasilpenelitian menunjukkan bahwa: (1) persepsi konsumen terhadap brand image tergolong tinggi denganrerata skor 27,85; (2) persepsi konsumen terhadap harga tergolong tinggi dengan rerata skor 28,65; (3)tingkat keputusan pembelian tergolong tinggi dengan rerata skor 47,1; (4) persepsi brand imageberpengaruh terhadap keputusan pembelian sebesar 9,9%; (5) persepsi harga berpengaruh terhadapkeputusan pembelian sebesar 23,1%; (6) Secara simultan persepsi brand image dan persepsi hargaberpengaruh terhadap keputusan pembelian pada pesan antar makanan online sebesar 33% adapun67% lainnya adalah variabel lain yang belum diteliti.