bluuebunny/crossref_metadata_2025 huggingface dataset:
Analytical Modelling of an Active Vibration Absorber for a Beam
Authors: Rincon Carlos , Alencastre Jorge , Rivera Richard
Published: April 2023

Attenuation of mechanical vibrations is an ongoing field of research in engineering aiming at reducing damage and improving performance in the presence of dynamical forces. Different alternatives have been proposed over time; the active vibration absorber can be highlighted as an alternative which can absorb the vibration from system in real time. In this study, an active vibration absorber was modelled as an electromechanical device. It was applied to a cantilever beam, mathematically modelled as a continuous beam. A set of differential equations representing the dynamical behaviour of the cantilever beam and active vibration absorber was obtained and it was simulated in Matlab Simulink®. Results indicated that the active vibration absorber is able to significantly reduce the vibration amplitudes of a system, especially in resonance conditions. The analytical model and procedure developed here can easily spread to any more complex system.
Sustainable Supplier Selection and Order Allocation Using an Integrated ROG-Based Type-2 Fuzzy Decision-Making Approach
Authors: Keshavarz-Ghorabaee Mehdi
Published: April 2023

The sustainable Supplier Evaluation and Selection and Order Allocation (SSOA) problem has received significant attention in supply chain management due to its potential to enhance a company’s performance, improve customer satisfaction, and reduce costs. In this study, an integrated methodology is proposed to address the SSOA problem. The methodology combines multiple techniques to handle the uncertainties associated with supplier evaluation, including a new ranking method based on the concept of Radius of Gyration (ROG) for interval type-2 fuzzy sets. The methodology also incorporates both subjective weights obtained using the Simple Multi-Attribute Rating Technique (SMART) and expert preferences, and objective weights calculated using the Method based on the Removal Effects of Criteria (MEREC) method to determine the weights of evaluation criteria. Some criteria for sustainable development are used to evaluate supplier performance, resulting in type-2 fuzzy sets, which are evaluated using the Weighted Aggregated Sum Product Assessment (WASPAS) method. The ROG-based ranking method is employed to calculate the relative scores of suppliers. Finally, a multi-objective decision-making (MODM) mathematical model is presented to identify suitable suppliers and allocate their order quantities. The methodology is demonstrated in a sustainable SSOA problem and is shown to be efficient and effective, as the ROG-based ranking method allows for more accurate supplier performance evaluation, and the use of the criteria highlights the importance of sustainability in supplier selection and order allocation. The methodology’s practicality is further supported by the analysis conducted in this study, which demonstrates the methodology’s ability to handle the uncertainties associated with supplier evaluation and selection. The proposed methodology offers a comprehensive approach to the SSOA problem that can effectively handle the uncertainties in supplier evaluation and selection and promote sustainable practices in supply chain management.
Generic Model of Max Heteroassociative Memory Robust to Acquisition Noise
Authors: Trujillo-Mora Valentín , Moreno-Ibarra Marco , Marroquín-Gutiérrez Francisco , Salgado-Ramírez Julio-César
Published: April 2023

Associative memories are a significant topic in pattern recognition, and therefore, throughout history, numerous memory models have been designed due to their usefulness. One such model is the associative memory minmax, which is highly efficient at learning and recalling patterns as well as being tolerant of high levels of additive and subtractive noise. However, it is not efficient when it comes to mixed noise. To solve this issue in the associative memory minmax, we present the generic model of heteroassociative memory max robust to acquisition noise (mixed noise). This solution is based on understanding the behavior of acquisition noise and mapping the location of noise in binary images and gray-scale through a distance transform. By controlling the location of the noise, the associative memories minmax become highly efficient. Furthermore, our proposed model allows patterns to contain mixed noise while still being able to recall the learned patterns completely. Our results show that the proposed model outperforms a model that has already solved this type of problem and has proven to overcome existing methods that show some solution to mixed noise. Additionally, we demonstrate that our model is applicable to all associative minmax memories with excellent results.
Sharp Coefficient Bounds for a New Subclass of Starlike Functions of Complex Order γ Associated with Cardioid Domain
Authors: Al-Shaikh Suha B. , Matarneh Khaled , Abubaker Ahmad A. , Khan Mohammad Faisal
Published: April 2023

In this study, by using the concepts of subordination, we define a new family RM,N,λ,γ of starlike functions of complex order γ connected with the cardioid domain. The main contribution of this article consists of the derivations of sharp inequality, considering the functions belonging to the family RM,N,λ,γ of starlike functions in U. Particularly, sharp bounds of the first two Taylor–Maclaurin coefficients, sharp estimates of the Fekete–Szegö-type functionals, and coefficient inequalities are investigated for this newly defined family RM,N,λ,γ of starlike functions. Furthermore, for the inverse function and the logg(z)z function, we investigate the same types of problems. Several well-known corollaries are also highlighted to show the connections between prior research and the new findings.
On Generalizations of the Close-to-Convex Functions Associated with q-Srivastava–Attiya Operator
Authors: Breaz Daniel , Alahmari Abdullah A. , Cotîrlă Luminiţa-Ioana , Ali Shah Shujaat
Published: April 2023

The study of the q-analogue of the classical results of geometric function theory is currently of great interest to scholars. In this article, we define generalized classes of close-to-convex functions and quasi-convex functions with the help of the q-difference operator. Moreover, by using the q-analogues of a certain family of linear operators, the classes Kq,bsh, K˜q,sbh, Qq,bsh, and Q˜q,sbh are introduced. Several interesting inclusion relationships between these newly defined classes are discussed, and the invariance of these classes under the q-Bernadi integral operator was examined. Furthermore, some special cases and useful consequences of these investigations were taken into consideration.
Toward a Circular Bioeconomy: Exploring Pineapple Stem Starch Film as a Plastic Substitute in Single Use Applications
Authors: Namphonsane Atitiya , Suwannachat Phattarakarn , Chia Chin Hua , Wongsagonsup Rungtiwa , Smith Siwaporn Meejoo , Amornsakchai Taweechai
Published: April 2023

In this study, biodegradable starch film was developed from pineapple stem waste as a substitute for non-biodegradable petroleum-based films for single-use applications where strength is not too demanding. High amylose starch from a pineapple stem was used as the matrix. Glycerol and citric acid were used as additives to adjust the ductility of the material. Glycerol content was fixed at 25% while that of citric acid varied from 0 to 15% by weight of starch. Films with a wide range of mechanical properties can be prepared. As more citric acid is added, the film becomes softer and weaker, and has greater elongation at the break. Properties range from a strength of about 21.5 MPa and 2.9% elongation to a strength of about 6.8 MPa and 35.7% elongation. An X-ray diffraction study showed that the films were semi-crystalline. The films were also found to be water-resistant and can be heat-sealed. An example of a single-use package was demonstrated. A soil burial test confirmed that the material was biodegradable and completely disintegrated into sizes smaller than 1 mm within one month.
Design of Novel Letrozole Analogues Targeting Aromatase for Breast Cancer: Molecular Docking, Molecular Dynamics, and Theoretical Studies on Gold Nanoparticles
Authors: Edris Alaa , Abdelrahman Mohammed , Osman Wadah , Sherif Asmaa E. , Ashour Ahmed , Garelnabi Elrashied A. E. , Ibrahim Sabrin R. M. , Bafail Rawan , Samman Waad A. , Ghazawi Kholoud F. , Mohamed Gamal A. , Alzain Abdulrahim A.
Published: April 2023

The use of aromatase inhibitors is an established therapy for estrogen-dependent breast cancer in postmenopausal women. However, the only commercially available aromatase inhibitor, letrozole, is not highly selective; in addition to aromatase, it has an affinity for binding to desmolase, an enzyme involved in steroidogenesis, which explains the main side effects. Therefore, we designed new compounds based on the structure of letrozole. More than five thousand compounds were constructed based on the letrozole structure. Then, these compounds were screened for their binding ability toward the target protein, aromatase. Quantum docking, Glide docking, and ADME studies showed 14 new molecules with docking scores of ≤−7 kcal/mol, compared to the docking score of −4.109 kcal/mol of the reference, letrozole. Moreover, molecular dynamics (MD) and post-MD MM-GBSA calculations were calculated for the top three compounds, and the results supported in their interaction’s stability. Finally, the density-functional theory (DFT) study applied to the top compound to study the interaction with gold nanoparticles revealed the most stable position for the interaction with the gold nanoparticles. The results of this study confirmed that these newly designed compounds could be useful starting points for lead optimization. Further in vitro and in vivo studies are recommended for these compounds to verify these promising results experimentally.
A Novel Program Scheme for Z-Interference Improvement in 3D NAND Flash Memory
Authors: Jia Jianquan , Jin Lei , Jia Xinlei , You Kaikai
Published: April 2023

With gate length (Lg) and gate spacing length (Ls) shrinkage, the cell-to-cell z-interference phenomenon is increasingly severe in 3D NAND charge-trap memory. It has become one of the key reliability concerns for 3D NAND cell scaling. In this work, z-interference mechanisms were investigated in the programming operation with the aid of Technology Computer-Aided Design (TCAD) and silicon data verification. It was found that the inter-cell trapped charges are one of the factors causing z-interference after cell programming, and these trapped charges can be modulated during programming. Thus, a novel program scheme is proposed to suppress the z-interference by reducing the pass voltage (Vpass) of the adjacent cells during programming. As a result, the proposed scheme suppresses the Vth shift of 40.1% for erased cells with Lg/Ls = 31/20 nm. In addition, this work further analyzes the optimization and balance of program disturbance and z-interference with the scaling of cell Lg-Ls based on the proposed scheme.
Bismuth-Rich Co/Ni Bimetallic Metal–Organic Frameworks as Photocatalysts toward Efficient Removal of Organic Contaminants under Environmental Conditions
Authors: Siddiqa Ayesha , Akhter Toheed , Faheem Muhammad , Razzaque Shumaila , Mahmood Asif , Al-Masry Waheed , Nadeem Sohail , Hassan Sadaf Ul , Yang Hyunseung , Park Chan Ho
Published: April 2023

Active photocatalysts with an efficiency of 99% were prepared for the degradation of the industrial dye, methylene blue (MB), under visible light irradiation. These photocatalysts comprised Co/Ni-metal–organic frameworks (MOFs), to which bismuth oxyiodide (BiOI) was added as a filler to prepare Co/Ni-MOF@BiOI composites. The composites exhibited remarkable photocatalytic degradation of MB in aqueous solutions. The effects of various parameters, including the pH, reaction time, catalyst dose, and MB concentration, on the photocatalytic activity of the prepared catalysts were also evaluated. We believe that these composites are promising photocatalysts for the removal of MB from aqueous solutions under visible light.
Favipiravir Inhibits Zika Virus (ZIKV) Replication in HeLa Cells by Altering Viral Infectivity
Authors: Franco Evelyn J. , Hanrahan Kaley C. , Brown Ashley N.
Published: April 2023

This study aims to evaluate the antiviral potential of the nucleoside analogue favipiravir (FAV) against ZIKV, an arbovirus for which there are no approved antiviral therapies, in three human-derived cell lines. HeLa (cervical), SK-N-MC (neuronal), and HUH-7 (liver) cells were infected with ZIKV and exposed to different concentrations of FAV. Viral supernatant was sampled daily, and infectious viral burden was quantified by plaque assay. Changes in ZIKV infectivity were quantified by calculating specific infectivity. FAV-related toxicities were also assessed for each cell line in both infected and uninfected cells. Our results demonstrate that FAV activity was most pronounced in HeLa cells, as substantial declines in infectious titers and viral infectivity were observed in this cell type. The decline in infectious virus occurred in an exposure-dependent manner and was more pronounced as FAV exposure times increased. Additionally, toxicity studies showed that FAV was not toxic to any of the three cell lines and, surprisingly, caused substantial improvements in the viability of infected HeLa cells. Although SK-N-MC and HUH-7 cells were susceptible to FAV’s anti-ZIKV activity, similar effects on viral infectivity and improvements in cell viability with therapy were not observed. These results indicate that FAV’s ability to substantially alter viral infectivity is host cell specific and suggest that the robust antiviral effect observed in HeLa cells is mediated through drug-induced losses of viral infectivity.
Metagenomic Sequencing Reveals the Taxonomic and Functional Characteristics of Rumen Micro-organisms in Gayals
Authors: Gao Huan , Yu Ye , Lv Yaqi , Wang Deao , Li Haonan , Li Zhe , Zhang Yuchen , Chen Lan , Leng Jing
Published: April 2023

As a semi-wild breed, Gayals have a strong fiber degradation capacity, which is unique to the microbial structure and function of their rumen. In this study, the unique rumen microbial composition and function of Gayals were investigated by metagenomic sequencing, with the Yunnan yellow cattle as the control. We compared the differences in rumen micro-organisms between Gayals and the Yunnan Yellow cattle, and the results showed that there were differences in bacteria, archaea and fungi between Gayals and the Yunnan Yellow cattle, while no significant abundance changes were observed in the protozoa. In addition, the ratio of Firmicutes to Bacteroidetes (1.06) in Gayals was higher than that of the Yunnan Yellow cattle (0.66). Three enzymes (PTA, ACH and FTHFS) related to the acetate production pathway and five enzymes (BHBD, THL, PTB, BK and BCACT) involved in butyric acid production were annotated in this study. The CAZymes search results showed that the abundance of GH5, GH26, GH94, CBM11 and CBM63 in Gayals was higher than in the Yunnan Yellow cattle (p < 0.05). Furthermore, this research constructed a model of rumen micro-organisms degrading fibers according to the characteristics and differences in the rumen microbiota structures and functions of the two breeds. This study expands our knowledge of the rumen microbiota and the mechanisms of fiber degradation in Gayals.
Irradiation as a Promising Technology to Improve Bacteriological and Physicochemical Quality of Fish
Authors: Mohamed Eman F.E. , Hafez Abd El-Salam E. , Seadawy Hanan G. , Elrefai Mohamed F.M. , Abdallah Karima , Bayomi Rasha M. , Mansour Abdallah Tageldein , Bendary Mahmoud M. , Izmirly Abdullah M. , Baothman Bandar K. , Alwutayd Khairiah Mubarak , Mahmoud Abdallah F.A.
Published: April 2023

Fish is an excellent source of protein and other essential minerals and vitamins; nevertheless, several food-borne disease outbreaks have been linked to the consumption of different types of fish. Therefore, we aimed to overcome these health threats by evaluating gamma radiation as a good fish preservation method. The aerobic plate count (APC), identification of most common pathogenic bacteria, organoleptic properties, proximate composition, and other chemical evaluations were detected in both untreated and gamma-treated fish. The overall grades of organoleptic evaluations ranged from good to very good. Fortunately, the overall chemical analysis of all examined fish samples was accepted. For the untreated fish samples, the APC was within and above the permissible limit (5 × 107 CFU/g). Pathogenic bacteria were detected with a high prevalence rate, especially S. aureus, which was found in high percentages among examined untreated fish samples. Regarding the treated fish samples, APC and pathogenic bacterial counts were reduced in a dose-dependent manner, and the irradiation at dose 5 KGy resulted in complete eradication of the aerobic plate count (not detectable) with a mean reduction percentage equal to 100%. However, gamma irradiation has no significant effect on proximate composition; particularly, carbohydrates, proteins, and lipids were not significantly affected by low and medium doses of radiation. Therefore, gamma irradiation is a highly effective fish preservation method without any effect on fish quality. Additionally, gamma irradiation as a cold process is an attractive technology for solving the problem arising from fish-borne pathogens, and it has been purposed in this study as a cheap and safe method for reducing microbial contamination of fish.
Effect of External Moisture Content on Screening Performance of Vibrating Flip-Flow Screen and Circular Vibrating Screen
Authors: Geng Runhui , Yu Chi , Wang Yixin , Wang Xinwen , Zhang Xiaokun , Li Ruile
Published: April 2023

Moisture content has an important influence on the stratification and screening of materials on the surface of screens, and materials with different external moisture concentrations present different screening characteristics. A vibrating flip-flow screen (VFFS) is a two-body vibration system with a high-vibrating-strength screen surface developed based on a circular vibrating screen (CVS), which offers significant advantages in terms of handling sticky fine particles. To better understand the difference in screening performance between a VFFS and CVS under different external moisture concentrations, it is necessary to conduct a comparative study on the distribution characteristics of materials on the screen’s surface. In this paper, a CVS dynamic model considering the stiffness force and position of the damping spring is proposed, and the influence of different arrangements of damping springs on the amplitude and angular displacement of the screen is analyzed. Under different external moisture concentrations, the screening percentages of the 3–1 mm sized fractions in sections I–IV of a VFFS and a CVS are greater than those of 1–0 mm sized fractions. The screening efficiencies of CVSs and VFFSs are 92.54% and 92.19%, respectively, at an external moisture content of 4.30%, so the screening effect of a low-vibration-intensity screen surface is better in the case of better material stratification. When the external moisture content of the material was increased from 4.30% to 8.19%, the screening efficiency of the VFFS and the CVS decreased by 33.85% and 41.32%, respectively. The screening efficiency of the CVS is more sensitive to the external moisture content of a material.
Constructing Molybdenum Phosphide@Cobalt Phosphide Heterostructure Nanoarrays on Nickel Foam as a Bifunctional Electrocatalyst for Enhanced Overall Water Splitting
Authors: Huang Yingchun , Chen Hongming , Zhang Busheng
Published: April 2023

The construction of multi-level heterostructure materials is an effective way to further the catalytic activity of catalysts. Here, we assembled self-supporting MoS2@Co precursor nanoarrays on the support of nickel foam by coupling the hydrothermal method and electrostatic adsorption method, followed by a low-temperature phosphating strategy to obtain Mo4P3@CoP/NF electrode materials. The construction of the Mo4P3@CoP heterojunction can lead to electron transfer from the Mo4P3 phase to the CoP phase at the phase interface region, thereby optimizing the charge structure of the active sites. Not only that, the introduction of Mo4P3 will make water molecules preferentially adsorb on its surface, which will help to reduce the water molecule decomposition energy barrier of the Mo4P3@CoP heterojunction. Subsequently, H* overflowed to the surface of CoP to generate H2 molecules, which finally showed a lower water molecule decomposition energy barrier and better intermediate adsorption energy. Based on this, the material shows excellent HER/OER dual-functional catalytic performance under alkaline conditions. It only needs 72 mV and 238 mV to reach 10 mA/cm2 for HER and OER, respectively. Meanwhile, in a two-electrode system, only 1.54 V is needed to reach 10 mA/cm2, which is even better than the commercial RuO2/NF||Pt/C/NF electrode pair. In addition, the unique self-supporting structure design ensures unimpeded electron transmission between the loaded nanoarray and the conductive substrate. The loose porous surface design is not only conducive to the full exposure of more catalytic sites on the surface but also facilitates the smooth escape of gas after production so as to improve the utilization rate of active sites. This work has important guiding significance for the design and development of high-performance bifunctional electrolytic water catalysts.
New Approved Drugs Appearing in the Pharmaceutical Market in 2022 Featuring Fragments of Tailor-Made Amino Acids and Fluorine
Authors: Wang Nana , Mei Haibo , Dhawan Gagan , Zhang Wei , Han Jianlin , Soloshonok Vadim A.
Published: April 2023

The strategic fluorination of oxidatively vulnerable sites in bioactive compounds is a relatively recent, widely used approach allowing us to modulate the stability, bio-absorption, and overall efficiency of pharmaceutical drugs. On the other hand, natural and tailor-made amino acids are traditionally used as basic scaffolds for the development of bioactive molecules. The main goal of this review article is to emphasize these general trends featured in recently approved pharmaceutical drugs.
The Electrodegradation Process in PZT Ceramics under Exposure to Cosmic Environmental Conditions
Authors: Lazar Iwona , Rodenbücher Christian , Bihlmayer Gustav , Randall Clive A. , Koperski Janusz , Nielen Lutz , Roleder Krystian , Szot Krzysztof
Published: April 2023

Long-time electric field action on perovskite piezoelectric ceramic leads to chemical degradation. A new way to accelerate the degradation is the exposure of the ceramic to DC electric fields under a vacuum. A high-quality commercial piezoelectric material based on PbZr1−xTixO3 is used to study such impacts. To avoid the influence of ferroelectric properties and possible removal of oxygen and lead oxides during the degradation process, the experiments are in the temperature interval of 500 °C > T > TC. Changes in resistance during the electrodegradation process is an electrically-induced deoxidation, transforming the ceramic into a metallic-like material. This occurs with an extremely low concentration of effused oxygen of 1016 oxygen atoms per 1 cm3. Due to this concentration not obeying the Mott criterion for an isolator-metal transition, it is stated that the removal of oxygen mostly occurs along the grain boundaries. It agrees with the first-principle calculations regarding dislocations with oxygen vacancies. The decrease in resistivity during electrodegradation follows a power law and is associated with a decrease in the dislocation dimension. The observed reoxidation process is a lifeline for the reconstructing (self-healing) properties of electro-degraded ceramics in harsh cosmic conditions. Based on all of these investigations, a macroscopic and nanoscopic model of the electrodegradation is presented.
Untargeted Lipidomics Method for the Discrimination of Five Crab Species by Ultra-High-Performance Liquid Chromatography High-Resolution Mass Spectrometry Combined with Chemometrics
Authors: Yao Jiaxu , Zhu Jinrui , Zhao Minjie , Zhou Li , Marchioni Eric
Published: April 2023

In this study, ultra-high-performance liquid chromatography high-resolution accurate mass-mass spectrometry (UHPLC-HRAM/MS) was applied to characterize the lipid profiles of five crab species. A total of 203 lipid molecular species in muscle tissue and 176 in edible viscera were quantified. The results indicate that Cancer pagurus contained high levels of lipids with a docosahexaenoic acid (DHA) and eicosapntemacnioc acid (EPA) structure in the muscle tissue and edible viscera. A partial least squares discriminant analysis (PLS-DA) showed that PE 16:0/22:6, PE P-18:0/20:5, PA 16:0/22:6 and PC 16:0/16:1 could be used as potential biomarkers to discriminate the five kinds of crabs. In addition, some lipids, such as PE 18:0/20:5, PC 16:0/16:1, PE P-18:0/22:6 and SM 12:1;2O/20:0, could be used as characteristic molecules to distinguish between Cancer magister and Cancer pagurus, which are similar in appearance. This study provides a new perspective on discriminating crab species from MS-based lipidomics.
Anticancer Potentials of the Lignan Magnolin: A Systematic Review
Authors: Bhuia Md. Shimul , Wilairatana Polrat , Chowdhury Raihan , Rakib Asraful Islam , Kamli Hossam , Shaikh Ahmad , Coutinho Henrique D. M. , Islam Muhammad Torequl
Published: April 2023

Magnolin is a naturally occurring, multi-bioactive lignan molecule with inherent anticancer effects. This study aims to summarize the botanical origins and anticancer properties of magnolin. For this, a recent (as of March 2023) literature review was conducted using various academic search engines, including PubMed, Springer Link, Wiley Online, Web of Science, Science Direct, and Google Scholar. All the currently available information about this phytochemical and its role in various cancer types has been gathered and investigated. Magnolin is a compound found in many different plants. It has been demonstrated to have anticancer activity in numerous experimental models by inhibiting the cell cycle (G1 and G2/M phase); inducing apoptosis; and causing antiinvasion, antimetastasis, and antiproliferative effects via the modulation of several pathways. In conclusion, magnolin showed robust anticancer activity against many cancer cell lines by altering several cancer signaling pathways in various non- and pre-clinical experimental models, making it a promising plant-derived chemotherapeutic option for further clinical research.
The Benefits and Challenges of Antibiotics–Non-Steroidal Anti-Inflammatory Drugs Non-Covalent Reaction
Authors: Nugrahani Ilma , Herawati Diar , Wibowo Marlia Singgih
Published: April 2023

Recently, non-covalent reactions have emerged as approaches to improve the physicochemical properties of active pharmaceutical ingredients (API), including antibiotics and non-steroidal anti-inflammatory drugs (NSAIDs). This review aimed to present and discuss the non-covalent reaction products of antibiotics, including salt and neutral multi-component solid forms, by framing their substituents and molar ratios, manufacturing techniques, characterization methods, benefits, potency changes, and toxicity, and is completed with an analysis of the development of computational models used in this field. Based on the data, NSAIDs are the most-developed drugs in multi-component system preparations, followed by antibiotics, i.e., antituberculosis and fluoroquinolones. They have reacted with inorganic elements, excipients, nutraceuticals, natural products, and other drugs. However, in terms of treatments for common infections, fluoroquinolones are more frequently used. Generally, NSAIDs are acquired on an over-the-counter basis, causing inappropriate medication. In addition, the pKa differences between the two groups of medicine offer the potential for them to react non-covalently. Hence, this review highlights fluoroquinolone–NSAID multi-component solid systems, which offer some benefits. These systems can increase patient compliance and promote the appropriate monitoring of drug usage; the dual drug multi-component solids have been proven to improve the physicochemical properties of one or both components, especially in terms of solubility and stability. In addition, some reports show an enhancement of the antibiotic activity of the products. However, it is important to consider the possibility of activity changes, interaction, and toxicity when using drug combinations. Hence, these aspects also are discussed in this review. Finally, we present computational modeling, which has been utilized broadly to support multi-component system designs, including coformer screening, preparation methods, and structural modeling, as well as to predict physicochemical properties, potency, and toxicity. This integrated review is expected to be useful for further antibiotic–NSAID multi-component system development.
Organic-Cation Modulated Assembly Behaviors of a Ureidopyrimidone-Grafting Cluster
Authors: Jiang Fengrui , Wang Jiaxu , Li Bao , Wu Lixin
Published: April 2023

Ureidopyrimidone (UPy) is an important building block for constructing functional supramolecular polymers and soft materials based on their characteristic quadruple hydrogen bonds. While the evidence from the single-crystal X-ray diffraction data for the existence of linear hydrogen bonding has still been absent up to now. To obtain the crystals of UPy-containing molecules with high quality, enhanced rigidity and crystallinity are expected. Herein, an inorganic Anderson–Evans type cluster [Mn(OH)6Mo6O18]3−, which can provide suitable stiffness and charge, is used as a linker to covalently anchor two UPy units. The prepared organic–inorganic polyanion with three negative charges has a linear architecture, which is prone to form an infinite one-dimensional structure based on the supramolecular forces. The results indicate that the combination models of UPy units can be conveniently modulated by organic counter cations with different sizes, and therefore three unreported models are observed under various conditions. The present study gives a unique understanding of the intermolecular interactions in UPy-based supramolecular polymers and also provides a simple tuning method, which benefits the construction of functional materials and the adjustment of their properties.
Anxiolytic-like Effects and Quantitative EEG Profile of Palmitone Induces Responses Like Buspirone Rather Than Diazepam as Clinical Drugs
Authors: Onofre-Campos Daniela , González-Trujano María Eva , Moreno-Pérez Gabriel Fernando , Narváez-González Fernando , González-Gómez José David , Villasana-Salazar Benjamín , Martínez-Vargas David
Published: April 2023

Anxiety is a mental disorder with a growing worldwide incidence due to the SARS-CoV-2 virus pandemic. Pharmacological therapy includes drugs such as benzodiazepines (BDZs) or azapirones like buspirone (BUSP) or analogs, which unfortunately produce severe adverse effects or no immediate response, respectively. Medicinal plants or their bioactive metabolites are a shared global alternative to treat anxiety. Palmitone is one active compound isolated from Annona species due to its tranquilizing activity. However, its influence on neural activity and possible mechanism of action are unknown. In this study, an electroencephalographic (EEG) spectral power analysis was used to corroborate its depressant activity in comparison with the anxiolytic-like effects of reference drugs such as diazepam (DZP, 1 mg/kg) and BUSP (4 mg/kg) or 8-OH-DPAT (1 mg/kg), alone or in the presence of the GABAA (picrotoxin, PTX, 1 mg/kg) or serotonin 5-HT1A receptor antagonists (WAY100634, WAY, 1 mg/kg). The anxiolytic-like activity was assayed using the behavioral response of mice employing open-field, hole-board, and plus-maze tests. EEG activity was registered in both the frontal and parietal cortex, performing a 10 min baseline and 30 min recording after the treatments. As a result, anxiety-like behavior was significantly decreased in mice administered with palmitone, DZP, BUSP, or 8-OH-DPAT. The effect of palmitone was equivalent to that produced by 5-HT1A receptor agonists but 50% less effective than DZP. The presence of PTX and WAY prevented the anxiolytic-like response of DZP and 8-OH-DPAT, respectively. Whereas only the antagonist of the 5-HT1A receptor (WAY) inhibited the palmitone effects. Palmitone and BUSP exhibited similar changes in the relative power bands after the spectral power analysis. This response was different to the changes induced by DZP. In conclusion, brain electrical activity was associated with the anxiolytic-like effects of palmitone implying a serotoninergic rather than a GABAergic mechanism of action.
Free Vibration Analysis of Functionally Graded Porous Cylindrical Panels Reinforced with Graphene Platelets
Authors: Cho Jin-Rae
Published: April 2023

The free vibration of functionally graded porous cylindrical shell panels reinforced with graphene platelets (GPLs) was numerically investigated. The free vibration problem was formulated using the first-order shear deformation shell theory in the framework of the 2-D natural element method (NEM). The effective material properties of the GPL-reinforced shell panel were evaluated by employing the Halpin–Tsai model and the rule of mixtures and were modified by considering the porosity distribution. The cylindrical shell surface was transformed into the 2-D planar NEM grid to avoid complex computation, and the concept of the MITC3+shell element was employed to suppress shear locking. The numerical method was validated through benchmark experiments, and the free vibration characteristics of FG-GPLRC porous cylindrical shell panels were investigated. The numerical results are presented for four GPL distribution patterns (FG-U, FG-X, FG-O, and FG-Λ) and three porosity distributions (center- and outer-biased and uniform). The effects of GPL weight, porosity amount, length–thickness and length–radius ratios, and the aspect ratio of the shell panel and boundary condition on the free vibration characteristics are discussed in detail. It is found from the numerical results that the proposed numerical method accurately predicts the natural frequencies of FG-GPLRC porous cylindrical shell panels. Moreover, the free vibration of FG-GPLRC porous cylindrical shell panels is significantly influenced by the distribution pattern as well as the amount of GPLs and the porosity.
Tunable Heat-Flux Rectification in Graded Nanowires in Non-Linear Guyer-Krumhansl Regime
Authors: Carlomagno Isabella , Cimmelli Vito Antonio , Jou David
Published: April 2023

We study heat rectification in composition-graded nanowires, with nonlocal and nonlinear effects taken into account in a generalized Guyer-Krumhansl equation. Using a thermal conductivity dependent on composition and temperature, the heat equation is solved. Introducing a non-vanishing heat supply (as for instance, a lateral radiative heat supply), we explore the conditions under which either nonlocal or nonlinear effects or both contribute to heat rectification and how they may be controlled by means of the external radiative flux. The corresponding rectification coefficients are calculated as well, and the physical conditions under which the system becomes a thermal diode are pointed out.
Fabrication of Poly Dopamine@poly (Lactic Acid-Co-Glycolic Acid) Nanohybrids for Cancer Therapy via a Triple Collaboration Strategy
Authors: Li Yunhao , Gao Yujuan , Pan Zian , Jia Fan , Xu Chenlu , Cui Xinyue , Wang Xuan , Wu Yan
Published: April 2023

Breast cancer is a common malignant tumor among women and has a higher risk of early recurrence, distant metastasis, and poor prognosis. Systemic chemotherapy is still the most widely used treatment for patients with breast cancer. However, unavoidable side effects and acquired resistance severely limit the efficacy of treatment. The multi-drug combination strategy has been identified as an effective tumor therapy pattern. In this investigation, we demonstrated a triple collaboration strategy of incorporating the chemotherapeutic drug doxorubicin (DOX) and anti-angiogenesis agent combretastatin A4 (CA4) into poly(lactic-co-glycolic acid) (PLGA)-based co-delivery nanohybrids (PLGA/DC NPs) via an improved double emulsion technology, and then a polydopamine (PDA) was modified on the PLGA/DC NPs’ surface through the self-assembly method for photothermal therapy. In the drug-loaded PDA co-delivery nanohybrids (PDA@PLGA/DC NPs), DOX and CA4 synergistically induced tumor cell apoptosis by interfering with DNA replication and inhibiting tumor angiogenesis, respectively. The controlled release of DOX and CA4-loaded PDA@PLGA NPs in the tumor region was pH dependent and triggered by the hyperthermia generated via laser irradiation. Both in vitro and in vivo studies demonstrated that PDA@PLGA/DC NPs enhanced cytotoxicity under laser irradiation, and combined therapeutic effects were obtained when DOX, CA4, and PDA were integrated into a single nanoplatform. Taken together, the present study demonstrates a nanoplatform for combined DOX, CA4, and photothermal therapy, providing a potentially promising strategy for the synergistic treatment of breast cancer.
Schottky-Diode Design for Future High-Speed Telecommunications
Authors: Wong Chi-Ho , Lam Leung-Yuk Frank , Hu Xijun , Tsui Chi-Pong , Zatsepin Anatoly Fedorovich
Published: April 2023

The impact of 5G communication is expected to be widespread and transformative. It promises to provide faster mobile broadband speeds, lower latency, improved network reliability and capacity, and more efficient use of wireless technologies. The Schottky diode, a BN/GaN layered composite contacting bulk aluminum, is theoretically plausible to harvest wireless energy above X-band. According to our first principle calculation, the insertion of GaN layers dramatically influences the optical properties of the layered composite. The relative dielectric constant of BN/GaN layered composite as a function of layer-to-layer separation is investigated where the optimized dielectric constant is ~2.5. To push the dielectric constant approaching ~1 for high-speed telecommunication, we upgrade our BN-based Schottky diode via nanostructuring, and we find that the relative dielectric constant of BN monolayer (semiconductor side) can be minimized to ~1.5 only if it is deposited on an aluminum monolayer (metal side). It is rare to find a semiconductor with a dielectric constant close to 1, and our findings may push the cut-off frequency of the Al/BN-based rectenna to the high-band 5G network.
Tissue-Engineered Nanomaterials Play Diverse Roles in Bone Injury Repair
Authors: Wan Teng , Zhang Meng , Jiang Hao-Ran , Zhang Yi-Chong , Zhang Xiao-Meng , Wang Yi-Lin , Zhang Pei-Xun
Published: April 2023

Nanomaterials with bone-mimicking characteristics and easily internalized by the cell could create suitable microenvironments in which to regulate the therapeutic effects of bone regeneration. This review provides an overview of the current state-of-the-art research in developing and using nanomaterials for better bone injury repair. First, an overview of the hierarchical architecture from the macroscale to the nanoscale of natural bone is presented, as these bone tissue microstructures and compositions are the basis for constructing bone substitutes. Next, urgent clinical issues associated with bone injury that require resolution and the potential of nanomaterials to overcome them are discussed. Finally, nanomaterials are classified as inorganic or organic based on their chemical properties. Their basic characteristics and the results of related bone engineering studies are described. This review describes theoretical and technical bases for the development of innovative methods for repairing damaged bone and should inspire therapeutic strategies with potential for clinical applications.
Anti-cariogenic Properties of Lactobacillus plantarum in the Utilization of Galacto-Oligosaccharide
Authors: Huang Xinyan , Bao Jianhang , Zeng Yan , Meng Gina , Lu Xingyi , Wu Tong Tong , Ren Yanfang , Xiao Jin
Published: April 2023

Ecological approaches can help to correct oral microbial dysbiosis and drive the advent and persistence of a symbiotic oral microbiome, which benefits long-term dental caries control. The aim of this study was to investigate the impact of the prebiotic Galacto-oligosaccharide (GOS) on the growth of probiotics L. plantarum 14,917 and its effect on the inhibitory ability of L. plantarum 14,917 against the growth of Streptococcus mutans and Candida albicans in an in vitro model. Single-species growth screenings were conducted in TSBYE broth with 1% glucose and 1–5% GOS. Interaction experiments were performed using duo- and multi-species models with inoculation of 105 CFU/mL S. mutans, 103 CFU/mL C. albicans, and 108 CFU/mL L. plantarum 14,917 under 1%, 5% GOS or 1% glucose. Viable cells and pH changes were measured. Real-time PCR was utilized to assess expression of C. albicans and S. mutans virulence genes. Six replicates were used for each group. Student’s t-test, one-way ANOVA, and Kruskal-Wallis were employed to compare the outcomes of different groups. GOS significantly inhibited the growth of C. albicans and S. mutans in terms of growth quantity and speed when the two strains were grown individually. However, GOS did not affect the growth of L. plantarum 14,917. Moreover, 1% and 5% GOS enhanced the anti-fungal performance of L. plantarum 14,917 in comparison to 1% glucose. GOS as the carbon source resulted in a less acidic environment in the C. albicans and S. mutans duo-species model and multispecies model where L. plantarum 14,917 was added. When GOS was utilized as the carbohydrate substrate, S. mutans and C. albicans had a significant reduction in the expression of the HWP1, ECE1, atpD, and eno genes (p < 0.05). To our knowledge, this is the first study that reported the ability of GOS to neutralize S. mutans-C. albicans high caries of medium pH and to disrupt virulence gene expression. Moreover, as a prebiotic, GOS augmented the inhibitory ability of L. plantarum against C. albicans in vitro. The current study revealed the anti-caries potential of prebiotics GOS and shed light on novel caries prevention strategies from the perspective of prebiotics and probiotics. These findings provide a rationale for future biofilm or clinical studies to elucidate the effect of GOS on modulating oral microbiota and caries control.
Aligning the Epidemiology of Malnutrition with Food Fortification: Grasp Versus Reach
Authors: Bourassa Megan W. , Atkin Reed , Gorstein Jonathan , Osendarp Saskia
Published: April 2023

Large-scale food fortification (LSFF) has been recognized as one of the most cost-effective interventions to improve the intake of vitamins and minerals and decrease the burden of micronutrient deficiency. Indeed, the simple addition of micronutrients to staple foods, such as wheat, maize and rice, or condiments, including salt and bouillon, has tremendous potential to impact malnutrition. However, most LSFF programs have been poorly designed and have not taken into consideration critical inputs, including current levels of nutrient inadequacy and per capita consumption of different food vehicles when deciding which nutrients to add and at what concentrations. LSFF programs, like some other nutrition interventions, also tend to have low coverage and reach and lack monitoring to measure this and course correct. These program design flaws have resulted in limited effectiveness and have made it difficult to determine how best to harmonize LSFF with other interventions to reduce micronutrient deficiencies, including efforts to enhance dietary diversity, biofortification and supplementation. Furthermore, LSFF has often been touted as a population-based intervention, but in fact has heterogenous effects among sub-groups, particularly those with limited access to or inability to afford fortified foods, as well as those with higher physiological requirements, such as pregnant and lactating women. This article focuses on these limitations and the concerted efforts underway to improve the collection, analysis, and use of data to better plan LSFF programs, track implementation, and monitor coverage and impact. This includes a more sophisticated secondary analysis of existing data, innovations to increase the frequency of primary data collection and programmatically relevant visualizations of data of sub-national estimates. These improvements will enable better use of data to target resources and programmatic efforts to reach those who stand to benefit most from fortification.
HMC Ameliorates Hyperglycemia via Acting PI3K/AKT Pathway and Improving FOXO1 Pathway in ob/ob Mice
Authors: Yoo Jeong , Park Jae Eun , Han Ji Sook
Published: April 2023

Type 2 diabetes is a disease characterized by hyperglycemia and is a growing health problem worldwide. Since many known diabetes drugs are side effects, it is necessary to develop natural substances with guaranteed safety. HM-chromanone isolated from Portulaca oleracea L. is a homoisoflavonoid compound. We investigated the effects of HM-chromanone on hyperglycemia and its mechanism in C57BL/6J ob/ob mice. C57BL/6J-Jms Slc mice were used as the control group, and C57BL/6J-ob/ob mice were divided into three groups: ob/ob (control), metformin (Met; positive control), and HM-chromanone (HMC). Fasting blood glucose was lower in the HMC group than those in the ob/ob group. Insulin resistance was improved by reducing HbA1c, plasma insulin, and HOMA-IR levels in the HMC group. HMC administration decreased the phosphorylation of IRS-1ser307 and increased the phosphorylation of IRS-1tyr612, PI3K, phosphorylation of AKTser473, and PM-GLUT4 in the skeletal muscles of ob/ob mice, indicating improved insulin signaling. HMC administration also increased the phosphorylation of FOXO1 in the liver of ob/ob mice. This inhibited PEPCK and G6pase involved in gluconeogenesis and regulated phosphorylation of glycogen synthase kinase 3β and glycogen synthase involved in glycogen synthesis. In conclusion, HM-chromanone ameliorates hyperglycemia by PI3K/AKT and improves the FOXO1 in ob/ob mice.
Metabolic Biomarkers of Red Beetroot Juice Intake at Rest and after Physical Exercise
Authors: Giampaoli Ottavia , Ieno Cristian , Sciubba Fabio , Spagnoli Mariangela , Miccheli Alfredo , Tomassini Alberta , Aureli Walter , Fattorini Luigi
Published: April 2023

Background: Red beetroot is known to be a health-promoting food. However, little attention is placed on intestinal bioactive compound absorption. The aim of the study was to assess the urinary red beetroot juice (RBJ) intake biomarkers and possible differences in RBJ’s micronutrient absorption at rest or after physical exercise. Methods: This is a three-armed, single-blind study, involving seven healthy volunteers which were randomly divided into three groups and alternatively assigned to three experimental sessions: RBJ intake at rest, RBJ intake with physical activity, and placebo intake with physical activity. For each session, urine samples were collected before and 120, 180, and 240 min after the intake of RBJ or placebo. The same sampling times were employed for the experimental session at rest. The RBJ metabolic composition was also characterized to identify the urinary biomarkers derived from the intake. Results: 4-methylpyridine-2-carboxylic acid, dopamine-3-O-sulfate, glutamine, and 3-hydroxyisobutyrate were identified as RBJ intake biomarkers. Physical activity significantly increased only the dopamine-3-O-sulfate excretion 120 min after RBJ intake. Conclusions: Urinary dopamine-3-O-sulfate is related to RBJ dopamine content, while 4-methylpyridine-2-carboxylic acid is a betanin or betalamic acid catabolite. The different excretions of these metabolites following physical activity suggest a possible effect on the RBJ uptake depending on different transport processes through the mucosa, namely diffusion-mediated transport for dopamine and saturable transcellular transport for betalamic acid derivatives. These results open new perspectives in improving the absorption of natural bioactive molecules through physical activity.