bluuebunny/crossref_metadata_2025 huggingface dataset:
A Propensity Score–Matched Observational Study of Remdesivir in Patients with COVID-19 and Severe Kidney Disease
Authors: Seethapathy Rituvanthikaa , Zhao Sophia , Long Joshua D. , Strohbehn Ian A. , Sise Meghan E.
Published: December 2021

Key Points

Remdesivir was not approved in patients with eGFR <30 ml/min per 1.73 m2, and safety data are extremely limited.

Compared with matched controls who did not receive remdesivir, there was no increased risk of cardiac, kidney, liver, or neurologic adverse events.

Hyperglycemia was more common in remdesivir-treated patients; this may be explained by concomitant dexamethasone use.

Background

Remdesivir is not currently approved for patients with eGFR <30 ml/min per 1.73 m2. We aimed to determine the safety of remdesivir in patients with kidney failure.

Methods

This study was a retrospective cohort study of patients with COVID-19 hospitalized between May 2020 and January 2021 with eGFR <30 ml/min per 1.73 m2 who received remdesivir and historical controls with COVID-19 hospitalized between March 1, 2020 and April 30, 2020 prior to the emergency use authorization of remdesivir within a large health care system. Patients were 1:1 matched by propensity scores accounting for factors associated with treatment assignment. Adverse events and hospital outcomes were recorded by manual chart review.

Results

The overall cohort included 34 hospitalized patients who initiated remdesivir within 72 hours of hospital admission with eGFR<30 ml/min per 1.73 m2 and 217 COVID-19 controls with eGFR <30 ml/min per 1.73 m2. The propensity score–matched cohort included 31 remdesivir-treated patients and 31 nonremdesivir-treated controls. The mean age was 74.0 (SD=13.8) years, 57% were women, and 68% were white participants. A total of 26% had ESKD. Among patients who were not on dialysis prior to initiating remdesivir, one developed worsening kidney function (defined as ≥50% increase in creatinine or initiation of KRT) compared with three in the historical control group. There was no increased risk of cardiac arrythmia, cardiac arrest, altered mental status, or clinically significant anemia or liver function test abnormalities. There was a significantly increased risk of hyperglycemia, which may be partly explained by the increased use of dexamethasone in the remdesivir-treated population.

Conclusions

In this propensity score–matched study, remdesivir was well tolerated in patients with eGFR <30 ml/min per 1.73 m2.
Tratamento farmacológico de pacientes hipertensos
Authors: de Andrade Aglaneide Soares , dos Santos Aline Gabriele Lima , Oliveira Bianca Nayara Ferreira , de Lima Rodrigo Queiroz
Published: December 2021

INTRODUÇÃO: O acompanhamento farmacoterapêutico é uma das atividades de assistência farmacêutica, trata-se de uma atividade na qual o paciente está plenamente envolvido para conhecer melhor sua doença e para que possa ser atendido corretamente com um farmacêutico / químico responsável. Desta forma o paciente é aconselhado quanto ao modo de administração, controle e situações especiais no seu tratamento. OBJETIVO: Discutir a importância do acompanhamento farmacoterapêutico de pacientes hipertensos e analisar os tratamentos e medicamentos utilizados em pacientes hipertensos; evidenciando o papel do farmacêutico e os benefícios do correto acompanhamento farmacoterapêutico para paciente hipertenso. MÉTODOS: Foi realizado um levantamento de dados por meio de pesquisa bibliográfica em dissertações, teses e artigos nacionais e internacionais obtidos das bases de dados BIREME (Biblioteca Virtual em Saúde), LILACS (Literatura Latino-Americana e do Caribe em Ciências da Saúde), SCIELO (ScientificElectronic Library) e PUBMED (UsNational Library of Medicine). Como critérios de inclusão serão utilizados trabalhos publicados nos últimos 10 anos, com texto completo que envolvam a atuação do farmacêutico no tratamento da hipertensão arterial nos idiomas em português ou inglês. Como critérios de exclusão serão artigos repetidos e com insuficiência de dados e que não se enquadram ao objetivo da pesquisa após a leitura do título, resumo, texto completo. RESULTADOS: As bases para o tratamento farmacológico da HTA utilizam 6 classes principais de medicamentos para o tratamento da HTA: diuréticos, beta-bloqueadores, antagonistas do cálcio, inibidores da enzima de conversão da angiotensina (ACE)., Antagonistas do receptor da angiotensina II (ARA-II) e bloqueadores alfa-adrenérgicos ou bloqueadores alfas. Além disso, drogas de ação central e vasodilatadores arteriais também estão disponíveis. As extensas informações disponíveis sobre a eficácia dos anti-hipertensivos clássicos, diuréticos e betabloqueadores, na redução da morbimortalidade associada à síndrome hipertensiva, tornam esses medicamentos referência no tratamento da HTA. CONCLUSÕES: A terapia com medicamentos anti-hipertensivos deve agora ser considerada em todos os pacientes hipertensos, independentemente da idade. Um melhor gerenciamento farmacoterapêutico melhora os resultados gerais, mas ainda existem desafios para pacientes com alto risco cardiovascular.
PENGARUH KONDISI KEUANGAN, DEBT DEFAULT, UKURAN PERUSAHAAN, DAN PERTUMBUHAN PERUSAHAAN TERHADAP PENERIMAAN OPINI AUDIT GOING CONCERN
Authors: Setyanida Wahyu Delta , Srimindarti Ceacilia
Published: December 2021

This research aims to examinethe effect of. financial. condition, debt. default, size, and.Growth on going. concern. audit. opinion. All. manufacturing. companies. listed.onthe. Indonesia. Stock. Exchange. from. 2017. to. 2019 are. used. in. this. study. as.a population. Sample method used in this research is purposive sampling. The. samples. obtained. in. this. study. were. 215 samples. from. 494 manufacturing. companies. The method of analysis used in this research is logistic. regression.Analysis.The result of this research found that. financial. condition, debt. default, size, and growth. does. not. have. a significant.Impacton. going. concern. audit. opinion.The results of this study have implications for the company in order to avoid going concern audit opinion.
ANALISIS FAKTOR EKSTERNAL DAN INTERNAL TERHADAP KEPUTUSAN PEMBELIAN PRODUK HAND SANITIZER DI MASA PANDEMI COVID-19
Authors: Tambunan Leo Alexander
Published: December 2021

The purpose of this study is to find out what factors influence consumer decisions to buy hand sanitizer products during covid-19. This research was conducted on 100 people who made purchases of hand sanitizers. This research belongs to the type of descriptive research with survey method. The data in this study were obtained through observation and questionnaires. The data analysis technique in this study used Partial Least Square (PLS). Several tests were carried out including: descriptive statistical test, Measurement Model Test or Outer Model, and Structural Model Test or Inner Model. Based on the results of the study, it was found that external factors did not have a significant influence on purchasing decisions as indicated by a significance value of 0.233>0.05. while internal factors have a significant influence on purchasing decisions as indicated by a significance value of 0.000 <0.05. And the results obtained that simultaneously external factors and internal factors have an influence on purchasing decisions.
Consecuencias adversas a la legítima defensa propia e impropia como causa de justificación
Authors: López Cantoral Epifanio
Published: December 2021

La legítima defensa —propia e impropia— es un instituto jurídico de defensa de bienes jurídicos propios o de terceros, que opera frente a una agresión ilegítima, actual o inminente, que debe concurrir con los requisitos que prevé el artículo 20, inciso 3, del Código Penal vigente. Asimismo, usar el derecho a la legítima defensa como justificación a veces trae consigo consecuencias adversas no previsibles, como el daño o la lesión a bienes jurídicos de terceros, por ejemplo, la muerte o lesión de personas. Entonces, conlleva asumir la responsabilidad contra el accionante o el accionado, respectivamente. Más aún, ejercer tal derecho debe ser de última ratio, no de primera línea. En tal sentido, usarlo implica ser cuidadoso y responsable en cada circunstancia particular. Por ejemplo: no es lo mismo ejercer la legítima defensa sin que haya presencia de personas, que ejercerla en lugares con presencia de ellas.
Koronavirüs Hastalığı 2019 (Covid-19) Pandemisi ile Karşı Karşıya Kalan Sağlık Çalışanları Arasında Tükenmişlik Sendromu
Authors: TUNÇ Şeyhmus , GÖKLÜ Mehmet Rıfat
Published: December 2021

Amaç: Bu çalışmada üçüncü basamak pandemi hastanesinin kadın hastalıkları ve doğum ünitesinde görevli doktor, hemşire, ebe ve anestezi teknisyenlerinde tükenmişlik sendromu ile ilişkili risk faktörlerinin belirlen-mesi amaçlanmıştır.Materyal ve metod: Sosyo-demografik bilgileri ve iş yeri ile ilgili özellikleri içeren anket formu ile Maslach Tükenmişlik Ölçeğini 1-15 Eylül 2021 tarihleri arasında dolduran 316 katılımcı çalışmaya dahil edilmiştir.Bulgular: Genç çalışanlarda duyarsızlaşma skoru (p=0,001), kadınlarda duygusal tükenmişlik ve kişisel başarı skorları anlamlı olarak yüksek saptandı (p=0,043 ve p=0,003). Kadın hastalıkları ve doğum uzmanlarında diğer branşlara göre anlamlı olarak daha yüksek duygusal tükenmişlik ve duyarsızlaşma skorları bulunmuştur (p=0,021 ve p=0,038). Çalışılan birimler incelendiğinde, yoğun bakımda çalışanlarda en yüksek, poliklinikte çalışanlarda en düşük duyarsızlaşma tespit edilmiştir (p=0,039). Toplam hizmet süresindeki artış ile duyarsızlık skorundaki azalış ve kişisel başarı skorundaki yükseliş korele bulunmuştur (p=0,003 ve p=0,004). Meslekten beklentilerinin karşılanmadığını ya da kısmen karşılandığını belirtenlerde duygusal tükenmişlik skoru anlamlı yüksek saptanmıştır (p=0,032). Ekstra saat çalışanlarda duygusal tükenmişlik ve duyarsızlaşma skorları anlamlı yüksek bulunmuştur (p=0,004 ve p=0,012). Fiziki koşulların yetersiz olduğunu bildiren çalışanlarda duygusal tükenmişlik skorunda anlamlı yükseklik saptanmıştır (p<0,001). COVID-19’lu hastalara doğrudan hizmet sunan grupta duygusal tükenmişlik ve duyarsızlaşma skorunda anlamlı yükseklik, kişisel başarı skorunda anlamlı düşük-lük saptanmıştır(p=0,014, p=0,003 ve p=0,014).Sonuç: COVID-19 pandemisi çalışanlarda tükenmişlik sendromu riskinde artışa neden olmaktadır. Ağır çalışma koşulları ve çalışma ortamındaki fiziki yetersizlikler tükenmişlik sendromu riskini artıran diğer nedenlerdendir.Anahtar Kelimeler: COVID-19 Pandemisi, Tükenmişlik Sendromu, Kadın hastalıkları ve Doğum
The Effect of Peri-Implant Disease on Oxidative Stress Markers Levels in Peri-Implant Sulcus Fluid: A Cross-Sectional, Pilot Study
Authors: BİRBİRİ Emre , UZUNKAYA Meral , GÜNDOĞAR Hasan
Published: December 2021

Background: Peri-implant diseases are inflammatory diseases as periodontal disease. An array of oxidative stress markers has been examined in the disease and health of the periodontal tissues. The purpose of the study was to test whether peri-implant conditions have an impact on the peri-implant sulcus fluid oxidative stress markers.Materials and Methods: A total of 44 participants were included in the study. Collected samples divided 3 groups, 14 samples for healthy implants; 15 samples for peri-implant mucositis; and 15 samples for peri-implantitis. In clinical periodontal examination, plaque index (PI), modified bleeding index (mSBI), probing bleeding (BOP), probing pocket depth (PPD), gingival index (GI), modified plaque index (MPI) were measured. Peri-implant sulcus fluid (PISF) samples were collected for evaluating and measuring biochemical analysis of total oxidant status (TOS) and total antioxidant capacity (TAOC) and oxidative stress index (OSI).Results: The TOS level in PISF was statistically significantly higher in the peri-implantitis when compared to the healthy group (p=0.041). There was no statistically significant difference (p>0.05) between groups in terms of TAOC and OSI parameters.Conclusions: As a result of the current study, it can be said that, due to its inflammatory character, peri-implantitis can increase total oxidant status (TOS) in peri-implant sulcus fluid (PISF). Multicentered research is needed to explain which immunological mechanism triggers the oxidative system in peri-implantitis in order to understand the potential role of oxidative stress markers in peri-implant inflammation.
Teaching Mathematical Modeling of Cellular Systems with the VCell MathModel
Authors: King Jasia , Eroumé Kerbaï Saïd , Truckenmüller Roman , Giselbrecht Stefan , Cowan Ann , Loew Leslie M. , Carlier Aurélie
Published: December 2021

Mathematical biology has emerged as a powerful approach to describe and understand biological systems. Here, we introduce an interactive teaching tool with a practical hands-on skill session plan to introduce students to the various components of a mathematical model with 4 different mathematical approaches (i.e., ordinary differential equations, partial differential equations, stochastic differential equations, and spatial stochastic differential equations) and their advantages and disadvantages. As such, we provide a didactic summary for instructors and students interested in using VCell MathModels for mathematical modeling; this work is also valuable for mathematics-savvy users who would like to exploit fully the capabilities of the VCell software.
Narrativas de las formas de producir contenidos en Radio Universidad de Rosario, en el marco de las prácticas para estudiantes de la Licenciatura en Comunicación Social
Authors:   , Fernández Cívico Lucía
Published: December 2021

Las emisoras universitarias tienen en la Argentina una historia casi tan extensa como la misma radiodifusión. Cuatro años después del nacimiento de la radio en nuestro país (el 27 de agosto de 1920), surge también la radio de la Universidad Nacional de La Plata, el 5 de abril de 1924. La misma, fue producto de la Reforma Universitaria de 1918 que dio origen a un nuevo paradigma de educación superior postulando, entre otras cuestiones relevantes, la de vincular la Universidad al pueblo, inspirar la tarea extramuros y la extensión universitaria. Nos proponemos en la presente investigación, contribuir al análisis de este tipo de radios, en un sentido que excede lo meramente mediático y recupera aspectos pedagógicos y formativos. Para ello nos centramos en la experiencia concreta de institucionalización del Proyecto Académico Extracurricular “Prácticas en Radio Universidad de Rosario (FM 103.3)”, desarrollado en la Radio de la Universidad Nacional de Rosario (en adelante, Radio UNR) desde junio de 2017. Este trabajo aborda esta experiencia de intervención profesional donde se cruzan los campos de la comunicación y la educación, revisando la producción de contenidos radiales y contemplando su dimensión histórica, en función del desarrollo de la propuesta formativa de las prácticas para estudiantes.
GÖRÜNTÜ SINIFLANDIRMADA DERİN ÖĞRENME YÖNTEMLERİNİN KARŞILAŞTIRILMASI
Authors: DAĞLI İlker , ÖZTÜRK Ali
Published: December 2021

Bu çalışmada ESA (Evrişimsel Sinir Ağları), ResNet ve AİA (Ağ İçinde Ağ) yaklaşımları kullanılarak oluşturulan ve E-Model, R-Model, A-Model şeklinde adlandırılan derin öğrenme modellerinin farklı veri kümeleri üzerinde performansları karşılaştırılmıştır. CIFAR-10 veri kümesi için derin öğrenme modelleri sadece MİB (Merkezi İşlem Birimi) içeren bir makinede ve MİB ile GİB (Grafik İşlem Birimi) içeren bir makinede ayrı ayrı çalıştırılmıştır. Sadece MİB içeren makinede R-Model, A-Model ve E-Model için sırasıyla yaklaşık 415 saatlik, 129 saatlik ve 3.5 saatlik eğitim aşamaları sonucunda doğrulama veri seti üzerinde sırasıyla %82.76, %87.64 ve %83.47 doğruluk oranları elde edilmiştir. MİB ve GİB içeren makinede ise R-Model, A-Model ve E-Model için sırasıyla yaklaşık 4.45 saatlik, 2.20 saatlik ve 1.82 saatlik eğitim aşamaları sonucunda doğrulama veri seti üzerinde sırasıyla %82.61, %87.95 ve %82.43 doğruluk oranları elde edilmiştir. Diğer veri kümeleri için ise modeller MİB ve GİB içeren makinede çalıştırılarak deneysel sonuçlar elde edilmiştir. Oluşturulan derin öğrenme modellerinin yapıları, eğitim için kullanılan parametre değerleri, doğrulama verileri için elde edilen karmaşıklık matrisleri, doğruluk ve kayıp grafikleri ayrıntılı olarak verilmiştir.
ADAPTIVE OPERATION MODEL FOR INTERIOR SMART LOGISTICS IN CYBER PHYSICAL SYSTEMS
Authors: DÖNMEZ Emrah , OKUMUŞ Fatih , KOCAMAZ Fatih
Published: December 2021

Logistics operations are among the main activities in industrial production areas. Today, vehicles that are usually electric and manually operated by a driver are used to perform these operations. Logistics robots are an important alternative that can be used in this field, and their use in integration with cyber physical systems in industrial fields is increasingly common. The biggest advantage of the logistics robots is that they provide autonomous driving capabilities and optimum parameters for the entire system in accordance with industry 4.0 concept. In this study, an adaptive logistics robot system that can be integrated into the Cyber Physical System (CPS) system in an environment with cyber physical system infrastructure has been developed. In this context, positioning, path planning, multi-task allocation, energy management, task prioritization, optimization and obstacle avoidance issues are analyzed and simple solutions are proposed. The experiments have been carried out in eight different configurations and the average distance and energy costs have been improved by 5.1% and 6.6%, respectively.
ELEKTRİKLİ ARAÇLARDA KULLANILAN BATARYALAR VE TERMAL YÖNETİM SİSTEMLERİNİN İNCELENMESİ
Authors: KABA Muhammet Yasin , KALKAN Orhan , CELEN Ali
Published: December 2021

Günümüzde içten yanmalı motorlara sahip araçlarla karşılaştırıldıklarında çevreci ve daha yüksek verimli olmaları sebebiyle elektrikli araçlar ön plana çıkmaktadırlar. Elektrikli araçları oluşturan en önemli ekipmanlardan biri olan bataryanın seçimi ve termal yönetimi önemlidir. Bu çalışmada, elektrikli araçların genel görünümü (tarihçesi, sınıflandırılması, satış sayıları, pazar payları), elektrikli araçlarda kullanılabilecek batarya türleri ve batarya termal yönetim sistemleri araştırılırmıştır. Uygulamalarda yaygın olarak kullanılan farklı batarya çeşitleri karakteristik özelliklerine göre karşılaştırılmış olup bu bataryalar arasından elektrikli araçlarda kullanabilecek/kullanılan batarya türünün yüksek özgül enerji (118-250 Wh/kg), yüksek enerji yoğunluğu (200-400 Wh/L), yüksek özgül güç (200-430 W/kg), yüksek çevrim ömrü (2000) ve ideal çalışma sıcaklığı (-20oC-60oC) özellikleri ile lityum iyon bataryalar olduğu görülmüştür. Bu bataryalardan en fazla performansın elde edilmesi için kullanılabilecek termal yönetim sistemleri incelenmiş olup bu yöntemlerin avantaj ve dezavantajlarından bahsedilmiştir. Düşük ısıl yüke sahip araçlarda (hibrit elektrikli araçlar vb.) hava ile soğutmanın yeterli olduğu görülmüş olup yüksek ısıl yüke sahip araçlarda (tam elektrikli araçlarda) ise sıvı akışkanlı ve hibrit soğutma yöntemlerinin kullanımının uygun olduğu görülmüştür.
Design of Low Power Cam Memory Cell for the Next Generation Network Processors
Authors: Muralidharan K. , Uma Maheswari S.
Published: December 2021

In the modern world, high performance embedded applications in the field of multimedia, networking, and imaging are increasing day by day. These applications require high performance and more complex out-of-order superscalar processor. These complex dynamic instructions scheduling superscalar processors need higher levels of on-chip integration designs which are often associated with power dissipation. These out-of-order superscalar processors achieve higher performance compared to other processors by simultaneous fetching, decoding and execution for multiple instructions in out-of-order that are used in the next generation network processors. The main data path resources of the processor use CAM+RAM structure which is the major power consuming unit in the overall out-of-order processor design. The proposed new design of CAM+RAM with power-gating technique reduces the overall average power consumption compared to the conventional design without any significant impact on their performance.
Pueblos indígenas defensores del ambiente, estudio de casos emblemáticos en la corte interamericana de derechos.
Authors: Nieto del Valle Celia América , Huape Padilla Grecia Atenea , Barbosa Muñoz Perla Araceli , Padilla Gil Laura Leticia
Published: December 2021

Es una investigación con enfoque cualitativo, el objeto de estudio, analizar de diversas sentencias consideradas paradigmáticas por haber tutelado el medio ambiente en el seno Corte Interamericana de Derechos Humanos (Corte IDH). Estas sentencias son piezas cognitivas que reflejan entre otras cosas: la participación activa de las comunidades indígenas, testimonios, visitas in situ, peritajes ambientales, antropológicos, etcétera que en su conjunto, brindan una cosmovisión de la relación entre indígena-tierras. Hay que mencionar además, lapresente colaboración es una investigación documental-descriptiva; Por un lado, tiene como meta conocer ciertos casos dilucidados en la Corte Interamericana de Derechos Humanos sometidos por pueblos y comunidades indígenas en los que se implicó vulneración del ambiente. Por otro, devela las violaciones cometidas en contra del ambiente e indígenas, y por último, una vez llevado a cabo ese proceso con el estudio y análisis, se concluirá el papel que tienen las comunidades indígenas con el ambiente.
A EFICÁCIA DA FISIOTERAPIA NA QUALIDADE DE VIDA DE PESSOAS IDOSAS QUE SOFRERAM QUEDAS
Authors: Sarmanho Rafaela Karina Teles , Abdoral Patrick Roberto Gomes , Rodrigues Larissa Siqueira , Oliveira Eduarda de Melo Rodrigues e , Lima Juliana Bezerra , Silva Sara Adriane do Nascimento Feitosa da , Sarges Aysha de Cássia Lobato de , Mainardi Emily Macedo , Rodrigues Leandro Lopes , Coelho Cybelle Silva Do Couto
Published: December 2021

OBJETIVO: Avaliar a eficácia da fisioterapia na qualidade de vida em idosos que sofreram queda após intervenção. MÉTODOS: revisão integrativa da literatura acerca da relação entre queda nos idosos e a qualidade de vida. Foram selecionados artigos publicados nas bases de dados PubMed, BVS e Scielo utilizando os descritores: quality of life, aged e accientals fall, nos idiomas português, inglês e espanhol entre os anos 2019 e 2021 sendo selecionados dez artigos relevantes de acordo com os critérios de inclusão e exclusão da pesquisa. RESULTADOS: Entre todos os artigos pesquisados apenas dez se enquadraram nos critérios de inclusão. Foi visto que apesar da expectava de vida nas pessoas idosos terem aumentado não necessariamente eles têm qualidade de vida e foi observado que um grande número de idosos tem medo de sofrer quedas principalmente os que já caíram alguma vez em suas vidas e notou-se que a maior dificuldade encontrada após quedas é a dependência para locomoção e atividades de vida diária. CONCLUSÃO: Observou-se que idosos institucionalizados apresentaram maiores riscos a quedas, diminuição de atividades físicas e menor qualidade de vida em relação aos idosos da comunidade e que fisioterapia através de exercícios de fortalecimento muscular, equilíbrio e propriocepção promovem maior segurança em relação ao medo de cair gerando mais qualidade de vida.
Batas Waktu Mengqasar Salat bagi Musafir Menurut Ulama Empat Mazhab
Authors: Rachmat bin Badani Tempo  , Nuraeni Novira  , Auliya Ulhaq
Published: December 2021

The purpose of this research; 1) to find out the opinions of four mazhab scholars on the issue of the time limit for a traveler to be able to make up his prayers, the background of the differences and the opinion that is rajih. This research uses qualitative research through library research. Methods of normative theological approach and comparative approach. Research results; First, the Hanafi Mazhab: a traveler can make up his prayers for 15 days. Maliki and Shafi'i Mazhab; A traveler may make up his prayers for 4 days other than the day he arrives and leaves. Hanbali Mazhab: a traveler may make up his prayer for 4 days or 20 times of obligatory prayer, including the day of arrival and departure. The rajih views are the Shafi'i and Maliki Mazhab; Second, differences of opinion occur because this issue includes issues that are not explicitly discussed in the Shari'a ('amrun maskuutun 'anhu fi al-syar'i) so that each opinion is only guided by the conditions and actions quoted from the Prophet. The reason is because this issue is a problem that is not explicitly discussed in the Shari'a ('amrun maskuutun 'anhu fi al-syar'i). This triggers a difference of opinion regarding the traditions of the Prophet Muhammad. about traveling; Third, the opinion that is rajih in this matter is the opinion of the Shafi'i Mazhab and the Maliki Mazhab.
PENINGKATAN KUALITAS PRODUK OLAHAN JAMU TRADISIONAL PADA MASA PANDEMI COVID-19 DI DESA KOLAM
Authors: Ritonga Winsyahputra , Fitrawaty Fitrawaty , Panggabean Deo Demonta , Oktora Maya , Harahap Mukti Hamjah , Irfandi Irfandi , Syah Dedy Husrizal
Published: December 2021

Kegiatan pengabdian pada masyarakat ini dilaksanakan di Desa Kolam Kecamatan Percut Sei Tuan Kabupaten Deli Serdang, Sumatera Utara. Permasalahan yang dihadapi mitra yaitu teknologi pengolahan masih tradisional sehingga mitra mengalami kesusahan dalam memenuhi  kuantitas yang dibutuhkan dalam waktu singkat, khususnya teknologi dalam pemerasan dan penggiling bahan baku, dan penyusunan laporan keuangan. Sehubungan dengan permasalahan yang dihadapi mitra, maka pada program pengabdian kepada masyarakat ini akan diwujudkan dengan mentransferkan alat/mesin penggiling jamu, pelatihan pembukuan dan manajemen keuangan. Metode yang digunakan untuk mencapai tujuan kegiatan pengabdian ini adalah metode pendidikan, sosialisasi, pendampingan peningkatan produk, pelatihan pembukuan dan manajemen usaha. Hasil kegiatan ini berupa telah diberikannya alat TTG Mesin penggiling jamu, serta diadakannya pelatihan serta pendampingan manajemen usaha dan pembukuan keuangan. Tingkat keberhasilan dari kegiatan pengabdian pada masyarakat di buktikan dengan peningkatan produksi, pendapatan dan pengetahuan mitra
SISTEM INFORMASI PENJUALAN MAKANAN OLAHAN BERBASIS WEB PADA TOKO ANYAR BEKASI
Authors: Iriadi Nandang , Priatno Priatno , Sainan Sainan
Published: December 2021

Toko Anyar merupakan salah satuperusahaan penjualan makanan instant (siap saji) yangberada di daerah Bekasi. Pada Toko Anyar tersebutpenulis melakukan analisa sistem penjualan yangsedang berjalan saat ini. Penjualan yang dilakukandiperusahaan ternyata masih kurang mendapatkanpendapatan yang maksimal. Income yang tidak tentu,kurangnya promosi dan menjadikan Toko Anyarbelum dikenal dikalangan masyarakat luas. Desainpenelitian yang digunakan adalah bersifat deskriptifdengan pendekatan studi kasus pada Toko Anyar.Metode pendekatan yang digunakan terstuktur danmetode pengembangan sistem informasi penjualanberbasis web. Hasil penelitian menunjukan bahwaperancanagan sistem informasi penjualan danpemesanan berbasis web dapat membatu konsumendalam mengakses informasi mengenai produk yangdijual dan dalam melakukan pemesanan produk,mengimplementasikan sistem informasi yang meliputiimplementasi perangkat lunak, perangkat keras, basisdata antarmuka dari aplikasi yang dihasilkan. Tahapakhir adalah mengadakan pengujian terhadap aplikasi.
PERANCANGAN APLIKASI KOMITE SUMBER DAYA MANUSIA BERBASIS WEB PADA PT CENDANA TEKNIKA UTAMA JAKARTA
Authors: Ependi Ependi , Imron Muhammad
Published: December 2021

Penelitian ini bertujuan untuk mengimplementasikan suatu sistem Aplikasi Komite Sumber Daya Manusia (KSDM) online berbasis web yang dapat diandalkan, sehingga mampu menghasilkan informasi dan laporan yang lebih cepat, akurat dan relevan sesuai kebutuhan. Tempat penelitian adalah pada PT Cendana Teknika Utama Jakarta, perusahaan yang bergerak dalam bidang alat antrian dan bidang jasa pembuatan website. Sumber dan jenis data yang digunakan diperoleh melalui studi lapangan dan studi kepustakaan. Diantaranya dengan melakukan observasi dan interview langsung pada obyek penelitian serta ditunjang dengan literatur-literatur yang sesuai. Sedangkan metode analisis data yang digunakan adalah metode kualitatif deskriptif.Dari hasil penelitian, ditemukan kendala kendala dari sistem yang saat ini sedang berjalan, antara lain: banyak kertas yang terbuang karena penjadwalan talent menggunakan kertas, proses sidang talent harus tatap muka, proses pembuatan laporan dan cetak hasil sidang tidak dapat di akses secara online, dan sebagainya. Aplikasi KSDM online ini mampu mengatasi permasalahan diatas dan mengantisipasinya.Dengan dibangunnya aplikasi Komite Sumber Daya Manusia ini membantu proses pengambilan keputusan dalam mencari penyedia (supplier) yang tepat dalam kegiatan pengadaan barang pada PT. Cendana Teknika Utama. Aplikasi menunjang kegiatan operasional perusahaan sehingga dapat berjalan lebih efektif dan efisien.
Conexão entre múltiplas representações em atividades de função polinomial do 1º Grau
Authors: Aparecida de Faria Renata , Laburú Carlos Eduardo
Published: December 2021

O presente artigo apresenta 3 (três) das atividades componentes de uma pesquisa de mestrado que está fundamentada nos referenciais das Múltiplas Representações e na Teoria dos Registros de Representação Semiótica. Considerando que os objetos matemáticos são acessíveis somente por representações e que não podemos confundir o objeto matemático com sua representação (Duval,2009), o objetivo da pesquisa  foi investigar a mobilização de representações em diferentes registros do objeto  matemático Função  Polinomial do 1° Grau , com alunos do 1° ano do Ensino Médio em uma escola da Rede Pública do Norte do Paraná .A pesquisa denominada qualitativa apresentou os instrumentos de coletas de informações  anotações em diário de campo da pesquisadora- , gravações em áudio e protocolo dos estudantes.As interações dialógicas ocorridas no desenvolvimento das atividades,permitiram a inferência das Funções Pedagógicas (Ainsworth,2006) de complementar, restringir e/ou aprofundar a cada nova representação em conexão com a atividade cognitiva de conversão.
Paths of Length Three are $K_{r+1}$-Turán-Good
Authors: Murphy Kyle , Nir JD
Published: December 2021

The generalized Turán problem ex$(n,T,F)$ is to determine the maximal number of copies of a graph $T$ that can exist in an $F$-free graph on $n$ vertices. Recently, Gerbner and Palmer noted that the solution to the generalized Turán problem is often the original Turán graph. They gave the name "$F$-Turán-good" to graphs $T$ for which, for large enough $n$, the solution to the generalized Turán problem is realized by a Turán graph. They prove that the path graph on two edges, $P_2$, is $K_{r+1}$-Turán-good for all $r \ge 3$, but they conjecture that the same result should hold for all $P_\ell$. In this paper, using arguments based in flag algebras, we prove that the path on three edges, $P_3$, is also $K_{r+1}$-Turán-good for all $r \ge 3$.
$r$-Critical Numbers of Natural Intervals
Authors: Herzog Marcel , Kaplan Gil , Lev Arieh , Zigdon Romina
Published: December 2021

The critical number $cr(r,n)$ of natural intervals $[r,n]$ was introduced by Herzog, Kaplan and Lev in 2014. The critical number $cr(r,n)$ is the smallest integer $t$ satisfying the following conditions: (i) every sequence of integers $S=\{r_1=r\leq r_2\leq \dotsb\leq r_k\}$ with  $r_1+r_2 +\dotsb +r_k=n$ and $k\geq t$ has the following property: every integer between $r$ and $n-r$ can be written as a sum of distinct elements of $S$, and (ii) there exists $S$ with $k=t$, which satisfies that property. In this paper we study a variation of the critical number $cr(r,n)$ called the $r$-critical number $rcr(r,n)$.  We determine the value of $rcr(r,n)$ for all $r,n$ satisfying $r\mid n$.
An Internal Model-Based PID Control for Smart Shot Peening Operation
Authors: Nguyen V. B. , Ba T. , Teo A. , Ahluwalia K. , Aramcharoen A. , Kang C. W.
Published: December 2021

Current control systems for the shot peening operation merely rely on old technologies, which often require repetitive processes to obtain pre-validated Almen systems to guide industrial productions. These designs for the manufacturing paradigm are not efficient for complicated workflows in modern manufacturing operation. Thus, in this study, we propose a practical model-based control system to address the issues; especially for a smarter and automated shot peening machine. In particular, the closed-loop control system development utilizes a model-based proportional-integral-derivative (PID) control technology and extreme gradient boosting (XGBOOST) machine learning algorithm. The control system includes an internal process model, a proxy model, a model-based PID controller, and pressure sensors with a low-pass filter for feedback control. The developed control system is integrated into a physical shot peening machine for on-site control validation and demonstration. In both in-silico and on-site control demonstrations, the obtained control performance is stable, robust, and reliable for different operational conditions. The measurement intensities are very close to targeted setting intensities. All the differences are smaller than the industrial threshold of (±0.01 mmA). It implies that the control system can use in industrial peening operations without the need for Almen system development for operational guidance. In other words, the control system can significantly reduce the total cost of the actual production by eliminating the cost, time, and labor of the iterative trials to build the Almen system.
Assessment of Metal Pollution in the Sediments of Ras Al-Ardh and Yacht Club Marinas, Kuwait
Authors: El-Sammak Amr A. , Alotaibi Amal F.
Published: December 2021

This study aims to investigate the fate and behavior of five trace metals (Fe, Ni, Pb, Cu and V) in the surface sediments of two selected marinas, namely Ras Al-Ardh and Yacht Club, along the coastal area of Kuwait. Leached and total concentrations of Fe, Ni, Pb, Cu and V were measured along with the total organic carbon (TOC) and sediment grain size. The bioavailability of the trace metals was also determined using simple extraction techniques. The contamination factor (CF), enrichment factor (EF) and pollution load index (PLI) were used for assessing sediment quality at the marinas. The results indicated that TOC was related to the mean grain size, where higher TOC concentrations were associated with finer grain fractions. Trace metal distribution patterns were similar to the TOC in the sediments. The value of PLI showed that the Ras Al-Ardh marina had higher metal enrichment than that of the Yacht Club marina. The results of CF and EF indicated that the sediments within both marinas are "slightly polluted" to "moderately polluted". The sediments were less contaminated with Cu relative to Pb and Ni. The PLI class of metals at the Yacht Club indicated that the marina can be classified as "non-polluted" to "moderately polluted", while the Ras Al-Ardh marina can be classified as "moderately polluted" to "polluted". The study revealed that sediment grain size, TOC, and trace metal concentrations varied spatially within each marina depending on the type of development and the probable source of metals. Sediment quality has changed tremendously due to the expansion of tourism, progress in industrial activities and increase in recreational requirements near the coastal areas.
Airborne Magnetometry to Identify Metallic Debris to Support Dredging and Search Activities at the Brumadinho Disaster Site – A Case Study
Authors: Felix Cesar Alexandre , Tessler Thomaz Martino , Neto Arthur Ayres
Published: December 2021

This paper describes the procedures and results of an airborne magnetic survey using Unmanned Aerial Vehicle (UAV) conducted to support Search and Rescue (S&R) teams after the failure of a mining tailing dam at the Corrego do Feijão Mine, in the state of Minas Gerais, Southeast Brazil. The accident claimed 270 lives, practically destroying all the mine’s infrastructure. After the accident, the use of a fast, efficient, and cost-effective method to locate preferential sites for the rescue team to work was critical. Due to the difficulty of direct access to the impacted area, and since most of the affected infrastructure consisted of metallic materials, an airborne magnetometer was the logical choice. First, some performance tests were conducted in order to define the survey configurations, such as flight altitude, transect spacing and anomaly’s detectability threshold. After that, task priorities were set, and the survey area divided in small blocks according to their morphological characteristics using aerial photos of the impacted area. The results showed that the system was able to detect all relevant anomalies. The correlation of the anomalies with aerial photogrammetry helped to discard false anomalies, making the whole operation much more efficient. This increased the effectiveness of the S&R teams as well as the planning of the dredging operations by defining the preferential locations for the interventions.
Hubungan Pengetahuan Ibu Dengan Kejadian Stunting Pada Balita Umur 12-59 Bulan
Authors: Purnama AL Jumiarsih , Hasanuddin Indirwan , Sulaeman S
Published: December 2021

Stunting adalah gangguan kronik akibat kurangnya gizi sehingga menghambat pertumbuhan dan perkembangan pada bayi. Stunting adalah kondisi dimana terjadinya suatu  gangguan pertumbuhan fisik yang ditandai dengan pertumbuhan yang tidak optimal sebagai akibat dari ketidak seimbangan gizi (Apriluana & Fikawati, 2018). Stunting masih menjadi permasalahan besar untuk sebagian besar negara di dunia. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan ibu dengan kejadian stunting pada balita usia 12-59 bulan di wilayah kerja Puskesmas Lawawoi Kabupaten Sidrap. Jenis penelitian yang digunakan adalah penelitian deskriptif analitik dengan pendekatan cross sectional studi. Sampel dalam penelitian adalah 30 responden dengan teknik penarikan sampel Purposive sampling. Data hasil penelitian dianalisis dengan menggunakan uji chi square. Hasil penelitian diperoleh bahwa ada hubungan antara pengetahuan ibu dengan kejadian stunting dengan nilai p = 0,02 (p < α = 0,05) pada balita usia 12-59 bulan di wilayah kerja Puskesmas Lawawoi Kabupaten Sidrap.
Ecoturism as a Means of Formation of Ecological Consciousness and Culture of Personality
Authors: VYHOVSKYI Leonid , VYHOVSKA Tetiana
Published: December 2021

In the conditions of the global ecological crisis the problem of physical habitation of people as a biological species objectively arises in the foreground. The main reasons for the negative impact of human activities and society on the natural environment, which caused such a crisis, are revealed. Emphasis is placed on the fact that the reduction in society of the technocratic worldview in the life of mankind eventually led to such a negative situation. Emphasis is placed on the fact that in order to overcome it, firstly, it is necessary to rethink the relationship in the system «human — nature» at the global level and, accordingly, to form in the individual and society the need to replace the technological worldview with ecological. It turns out that a system-forming element in the system of ecological worldview is ecological consciousness which is ultimately managed to provide a spiritual basis for a set of environmental factors in human life and society. As a result, they become priorities in human life. Moreover, they can even become a meaning of human life. The content of the basic levels of ecological consciousness formation is revealed: national-realistic, everyday-empirical and conscious-theoretical. It is proved that the carriers of the national-realistic level are characterized by an intuitive approach to understanding the existing environmental problems. As for the everyday-empirical level of ecological consciousness, such people are interested in the practical solution of the problem in the field of ecology, which is directly related to them. And only the carriers of the conscious-theoretical level of ecological consciousness are characterized by a conscious and stable attitude towards environmental problems in all their manifestations. They are characterized by the active life position of protection and conservation of nature, which is realized in active environmental activities. It is proved that ecotourism serves as an effective means of forming and affirming the ecological consciousness and ecological culture of the individual and society, due to the fact that in the process of human interaction with the natural environment the need for care is formed. The content and correlation of the concepts «ecotourism», «biotourism», «natural tourism», «agritourism», «green tourism» are revealed. It turns out that ecotourism necessarily supports the «greening» of other types of tourism, which in their activities are beginning to teach not only the risks of negative impact of such activities on the environment, but also create efforts to ensure its preservation. The significant ecological potential of Khmelnytskyi region is revealed.
Religious Tourism in Khmelnytskyi Region
Authors: KULISH Nataliia
Published: December 2021

The article is devoted to the study of the phenomenon of religious tourism in Khmelnytskyi region. It is noted that religious tourism is realized in two formats: sightseeing and pilgrimage. It is stated that under modern conditions of Khmelnytskyi region there is a powerful layer of various religious monuments. Among these are, pagan «places of power», settlements-sanctuaries, temples, sacrificial wells, rock temples, dolmens, stone monumentalism. Christianity is widely represented: churches, cathedrals, churches, monasteries, churches, chapels. The Jewish sacred heritage is the follows; synagogues and necropolises became widespread in the region. Remains are considered interesting tourist locations elements of Muslim mosques and minarets. Emphasis is placed on the diversity of architectural forms, styles, purpose of religious buildings: stone churches, churches, defensive synagogues, wooden temples, rotunda churches; built in neo-Gothic, Renaissance, Baroque, Late Baroque, Classical, Greek, «pseudo-Russian», local styles; regimental churches, castle temples. Some examples of the historical past and present of sacred buildings are given. Emphasis is placed on the insufficiently-studied locations of religious tourism, they are «kissing ponds» — wells, springs, streams, lakes, many of which are in Khmelnytskyi region. Interesting tourist locations can be settlements that have given impetus to the development of various cultural phenomena related to religion. Sacred monuments destroyed during the Soviet period can have a powerful potential. Their identification, restoration, popularization will provide a solid basis for a broad understanding of the history of the region, the restoration of lost cultural strata and national memory.
Management and Prospects for the Development of Cultural Tourism in the Sea of Azov Region
Authors: ROMANOVA Anna
Published: December 2021

The cultural potential of the Sea of Azov region for the development of cultural tourism is analysed. There are three groups of cultural resources of the region: 1) objects of cultural material heritage and museum resources; 2) objects of intangible cultural heritage; 3) festival and event resources. The institutional capacity and attendance of the museum cluster of the Azov region are illustrated. A SWOT-analysis of the resources for the development of cultural tourism in the Azov region is conducted. The main problems and challenges of development of the tourist sector of the Sea of Azov region are identified: short tourism season; lack of information about the cultural potential of the Azov Sea region; unused cultural and historical resource; focus on budget beach holidays; non-perception by the inhabitants of the Azov region as a cultural center («inferiority complex»); low level of hospitality and service; unformed cultural tourism product; lack of tourist information centers, as well as authentic souvenirs, guides, navigation and pointers to cultural sites; unformed museum network and museum infrastructure; lack of conference seats to meet the needs of the industrial region; lack of quality unique festivals and large-scale interesting events for tourists, etc. The need to use significant cultural resources of the Sea of Azov region to increase the tourism attractiveness of the region is substantiated. Variants of cultural products of the Sea of Azov region are given: 1) event product (festivals; religious holidays and ceremonies, MICE-products); 2) art product (art tours, art vacations, photo tours); 3) film tourism (filming and tours of the filming locations); 4) cultural and cognitive tourism (city tours, industrial tours, sentimental tours, sacred tours). Methodological guidelines for creation and promotion of cultural tourism products in the region, in particular, recommendation of targeting priority of target audiences, conducting a large-scale marketing campaign to promote cultural tourism products for target audiences, organizing information tours for tour operators, bloggers and media, using digital marketing and online platforms are improved.
Sounds familiar(?): Expertise with specific musical genres modulates timing perception and micro-level synchronization to auditory stimuli
Authors: Danielsen Anne , Nymoen Kristian , Langerød Martin Torvik , Jacobsen Eirik , Johansson Mats , London Justin
Published: December 2021

Musical expertise improves the precision of timing perception and performance – but is this expertise generic, or is it tied to the specific style(s) and genre(s) of one’s musical training? We asked expert musicians from three musical genres (folk, jazz, and EDM/hip-hop) to align click tracks and tap in synchrony with genre-specific and genre-neutral sound stimuli to determine the perceptual center (“P-center”) and variability (“beat bin”) for each group of experts. We had three stimulus categories – Organic, Electronic, and Neutral sounds – each of which had a 2 × 2 design of the acoustic factors Attack (fast/slow) and Duration (short/long). We found significant effects of Genre expertise, and a significant interaction for both P-center and P-center variability: folk and jazz musicians synchronize to sounds typical of folk and jazz in a different manner than the EDM/hip-hop producers. The results show that expertise in a specific musical genre affects our low-level perceptions of sounds as well as their affordance(s) for joint action/synchronization. The study provides new insights into the effects of active long-term musical enculturation and skill acquisition on basic sensorimotor synchronization and timing perception, shedding light on the important question of how nature and nurture intersect in the development of our perceptual systems.
Assessment of infection of hamsa Engraulis encrasicolus nematode Hysterothylacium aduncum in the Sea of Azov in the summer and autumn periods 2015-2020
Authors: Mosesyan Georgiy , Dudkin Sergey , Strizhakova Tatiana
Published: December 2021

The dynamics of infection of anchovy Engraulis encrasicolus Linnaeus, 1758 with nematode parasite Hysterothylacium aduncum Rudolphi, 1802 in the Sea of Azov during the summer seasons of 2015 and 2017-2020 and autumn seasons of 2017-2020 is analyzed. To specify the scheme of infestation, the division of nematodes into living and degenerating ones was used. The degenerating specimens were attributed to three stages of destruction. The infection rate was estimated by using of the common parasitological indices (prevalence of infection, intensity values, abundance of larvae). Statistical analysis of data obtained in the process of the research was conducted using Spearman’s rank correlation.