bluuebunny/crossref_metadata_2025 huggingface dataset:
Indolcarboxamide Is a Preclinical Candidate for Treating Multidrug-Resistant Tuberculosis
Authors: Rao Srinivasa P. S. , Lakshminarayana Suresh B. , Kondreddi Ravinder R. , Herve Maxime , Camacho Luis R. , Bifani Pablo , Kalapala Sarath K. , Jiricek Jan , Ma Ng L. , Tan Bee H. , Ng Seow H. , Nanjundappa Mahesh , Ravindran Sindhu , Seah Peck G. , Thayalan Pamela , Lim Siao H. , Lee Boon H. , Goh Anne , Barnes Whitney S. , Chen Zhong , Gagaring Kerstin , Chatterjee Arnab K. , Pethe Kevin , Kuhen Kelli , Walker John , Feng Gu , Babu Sreehari , Zhang Lijun , Blasco Francesca , Beer David , Weaver Margaret , Dartois Veronique , Glynne Richard , Dick Thomas , Smith Paul W. , Diagana Thierry T. , Manjunatha Ujjini H.
Published: December 2013

The small-molecule indolcarboxamide is a potential drug candidate for treating multidrug-resistant tuberculosis.
Complete Genome of Acinetobacter baumannii N4-Like Podophage Presley
Authors: Farmer Nicholas G. , Wood Thammajun L. , Chamakura Karthik R. , Kuty Everett Gabriel F.
Published: December 2013

Acinetobacter baumannii
is an emerging multidrug-resistant nosocomial pathogen. Bacteriophages may be useful as an alternative method of treatment against this and other multidrug-resistant bacteria. Here, we present the complete genome sequence of
A. baumannii
phage Presley, an N4-like podophage.
Complete Genome of Bacillus pumilus Siphophage Glittering
Authors: Matthew Solomon P. , Decker Skyelar L. , Chamakura Karthik R. , Kuty Everett Gabriel F.
Published: December 2013

Bacillus pumilus
is a Gram-positive bacterium widely used in agriculture both as an antifungal and as a growth-promoting symbiont.
B. pumilus
is rarely infectious but has recently been shown to infect humans. Here, we present the complete genome of
B. pumilus
phage Glittering, a potential biocontrol agent for
B. pumilus
.
Complete Genome of Bacillus subtilis Myophage Grass
Authors: Miller Stanton Y. , Colquhoun Jennifer M. , Perl Abbey L. , Chamakura Karthik R. , Kuty Everett Gabriel F.
Published: December 2013

Bacillus subtilis
is a ubiquitous Gram-positive model organism. Here, we describe the complete genome of
B. subtilus
myophage Grass. Aside from genes encoding core proteins pertinent to the life cycle of the phage, Grass has several interesting features, including an FtsK/SpoIIIE protein.
Complete Genome of Bacillus thuringiensis Myophage Spock
Authors: Maroun Justin W. , Whitcher Kelvin J. , Chamakura Karthik R. , Kuty Everett Gabriel F.
Published: December 2013

Bacillus thuringiensis
is a Gram-positive, sporulating soil microbe with valuable pesticide-producing properties. The study of bacteriophages of
B. thuringiensis
could provide new biotechnological tools for the use of this bacterium. Here, we present the complete annotated genome of Spock, a myophage of
B. thuringiensis
, and describe its features.
Complete Genome of Bacillus megaterium Siphophage Staley
Authors: Hastings Waylon J. , Ritter Matthew A. , Chamakura Karthik R. , Kuty Everett Gabriel F.
Published: December 2013

Siphophage Staley was isolated because of its ability to grow on
Bacillus megaterium
. Here we report the complete genome and annotation of phage Staley and describe core features. Among its interesting genes is one encoding an SleB germination protein.
Draft Genome Sequence of Plant Growth-Promoting Rhizobacterium
Pantoea
sp. Strain AS-PWVM4
Authors: Khatri Indu , Kaur Sukhvir , Devi Usha , Kumar Navinder , Sharma Deepak , Subramanian Srikrishna , Saini Adesh K.
Published: December 2013

Nonpathogenic
Pantoea
spp. have been shown to confer biofertilizer and biocontrol activities, indicating their potential for increasing crop yield. Herein, we provide the high-quality genome sequence of
Pantoea
sp. strain AS-PWVM4, a Gram-negative motile plant growth-promoting rhizobacterium isolated from a pomegranate plant. The 4.9-Mb genome contains genes related to plant growth promotion and the synthesis of siderophores.
Genome Sequences of Two Enterobacter pulveris Strains, 601/05
T
(=LMG 24057
T
=DSM 19144
T
) and 1160/04 (=LMG 24058 =DSM 19146), Isolated from Fruit Powder
Authors: Gopinath Gopal R. , Grim Christopher J. , Tall Ben D. , Mammel Mark K. , Sathyamoorthy Venugopal , Trach Larisa H. , Chase Hannah R. , Fanning Séamus , Stephan Roger
Published: December 2013

We report the draft genome sequences of the
Enterobacter pulveris
strains 601/05
T
(=LMG24057
T
=DSM19144
T
) and 1160/04 (=LMG24058 =DSM19146), isolated from fruit powder. The genome assemblies for the
E. pulveris
type strain, LMG24057, and strain LMG24058 have sizes of 4,708,624 and 4,811,103 bp and G+C contents of 56.6% and 56.5%, respectively.
Genome Sequence of Parvimonas micra Strain A293, Isolated from an Abdominal Abscess from a Patient in the United Kingdom
Authors: Ang Mia Yang , Dymock David , Tan Joon Liang , Thong Ming Hang , Tan Qin Kai , Wong Guat Jah , Paterson Ian C. , Choo Siew Woh
Published: December 2013

Parvimonas micra
is an important oral microbe that has the ability to grow and proliferate within oral biofilms and is involved in periodontal disease, leading to gingival bleeding, gingival recession, alveolar bone loss, and tooth mobility. However, occasionally these normally oral pathogens can cause infections at other sites in the body. We present the genome sequence of
Parvimonas micra
strain A293, a smooth
Parvimonas micra
strain isolated from an abdominal abscess from a patient at Barts Hospital, London, United Kingdom.
The N-Terminal Membrane-Spanning Domain of the Escherichia coli DNA Translocase FtsK Hexamerizes at Midcell
Authors: Bisicchia Paola , Steel Bradley , Mariam Debela Mekdes H. , Löwe Jan , Sherratt David
Published: December 2013

Bacterial FtsK plays a key role in coordinating cell division with the late stages of chromosome segregation. The N-terminal membrane-spanning domain of FtsK is required for cell division, whereas the C-terminal domain is a fast double-stranded DNA (dsDNA) translocase that brings the replication termination region of the chromosome to midcell, where it facilitates chromosome unlinking by activating XerCD-
dif
site-specific recombination. Therefore, FtsK coordinates the late stages of chromosome segregation with cell division. Although the translocase is known to act as a hexamer on DNA, it is unknown when and how hexamers form, as is the number of FtsK molecules in the cell and within the divisome. Using single-molecule live-cell imaging, we show that newborn
Escherichia coli
cells growing in minimal medium contain ~40 membrane-bound FtsK molecules that are largely monomeric; the numbers increase proportionately with cell growth. After recruitment to the midcell, FtsK is present only as hexamers. Hexamers are observed in all cells and form before any visible sign of cell constriction. An average of 7 FtsK hexamers per cell are present at midcell, with the N-terminal domain being able to hexamerize independently of the translocase. Detergent-solubilized and purified FtsK N-terminal domains readily form hexamers, as determined by
in vitro
biochemistry, thereby supporting the
in vivo
data. The hexameric state of the FtsK N-terminal domain at the division site may facilitate assembly of a functional C-terminal DNA translocase on chromosomal DNA.

IMPORTANCE
In the rod-shaped bacterium
Escherichia coli
, more than a dozen proteins act at the cell center to mediate cell division, which initiates while chromosome replication and segregation are under way. The protein FtsK coordinates cell division with the late stages of chromosome segregation. The N-terminal part of FtsK is membrane embedded and acts in division, while the C-terminal part forms a hexameric ring on chromosomal DNA, which the DNA can translocate rapidly to finalize chromosome segregation. Using quantitative live-cell imaging, which measures the position and number of FtsK molecules, we show that in all cells, FtsK hexamers form only at the cell center at the initiation of cell division. Furthermore, the FtsK N-terminal portion forms hexamers independently of the C-terminal translocase.
Coexistent dermatofibrosarcoma protuberans and anticonvulsant-induced cutaneous lymphoid hyperplasia: diagnostic challenge
Authors: Chu Melinda B , Dhandha Maulik , Guo Aibing
Published: December 2013

A 60-year-old African-American male patient with a history of seizures, developmental delay, long history of behavioural issues with psychotic episodes, heart, liver, thyroid and kidney diseases presented for evaluation of a right neck skin lesion. Physical examination revealed a shiny purplish-red plaque on the right neck and a thin pink plaque on the posterior neck. The lesions were similar in appearance, but different enough to warrant skin biopsy of each. Pathology demonstrated mycosis fungoides (MF) on the right neck and dermatofibrosarcoma protuberans (DFSP) on the posterior neck. The identification of two rare conditions made us reconsider our diagnosis. After further review, the right neck skin lesion was thought to be anticonvulsant-induced cutaneous lymphoid hyperplasia, not MF. This case demonstrates how insufficient skin biopsy can have significant clinical consequences. Biopsy of the right neck only would have overlooked a DFSP and incorrectly given the patient a diagnosis of MF.
Phalangeal lytic lesion: do not forget osseous sarcoidosis
Authors: Cherif Eya , Ben Hassine Lamia , Kechaou Ines , Khalfallah Narjess
Published: December 2013

Sarcoidosis is a systemic granulomatous disease that most commonly involves the lung and thoracic lymph nodes. However, any organ can be affected. Osseous sarcoidosis has been reported in 3–13% of the cases. The skeletal involvement on radiographs is usually seen late in the course of the disease and is rarely the initial manifestation. We report a case of sarcoidosis revealed by a lytic lesion of the phalanx.
Responses to concerns about child maltreatment: a qualitative study of GPs in England
Authors: Woodman Jenny , Gilbert Ruth , Allister Janice , Glaser Danya , Brandon Marian
Published: December 2013

Objectives

To provide a rich description of current responses to concerns related to child maltreatment among a sample of English general practitioners (GPs).

Design

In-depth, face-to-face interviews (November 2010 to September 2011). Participants selected and discussed families who had prompted ‘maltreatment-related concerns’. Thematic analysis of data.

Setting

4 general practices in England.

Participants

14 GPs, 2 practice nurses and 2 health visitors from practices with at least 1 ‘expert’ GP (expertise in child safeguarding/protection).

Results

The concerns about neglect and emotional abuse dominated the interviews. GPs described intense and long-term involvement with families with multiple social and medical problems. Narratives were distilled into seven possible actions that GPs took in response to maltreatment-related concerns. These were orientated towards whole families (monitoring and advocating), the parents (coaching) and children (opportune healthcare), and included referral to or working with other services and recording concerns. Facilitators of the seven actions were: trusting relationships between GPs and parents, good working relationships with health visitors and framing the problem/response as ‘medical’. Narratives indicated significant time and energy spent building facilitating relationships with parents with the aim of improving the child's well-being.

Conclusions

These GPs used core general practice skills for on-going management of families who prompted concerns about neglect and emotional abuse. Policy and research focus should be broadened to include strategies for direct intervention and on-going involvement by GPs, such as using their core skills during consultations and practice systems for monitoring families and encouraging presentation to general practice. Exemplars of current practice, such as those identified in our study, should be evaluated for feasibility and acceptability in representative general practice settings as well as tested for efficacy, safety and cost. The seven actions could form the basis for the ‘lead professional’ role in general practice as proposed in the 2013 version of ‘Working Together ’guidance.
‘Looking for the needle in the haystack’: a qualitative study of the pathway to diagnosis of type 1 diabetes in children
Authors: Usher-Smith Juliet A , Thompson Matthew J , Walter Fiona M
Published: December 2013

Objective

To explore the pathway to diagnosis of type 1 diabetes (T1D) in children from the perspective of the child, family and general practitioner (GP).

Design

Qualitative interview study.

Participants

Parents of children aged 1 month to 16 years diagnosed with new onset T1D within the previous 3 months, children over 6 years diagnosed with new onset T1D within the previous 3 months and GPs who saw those children prior to diagnosis.

Setting

Children and parents were identified and recruited from two hospitals within the East of England.

Results

The parents of 16 children (2–16 years) were interviewed. The total interval from onset of symptoms to diagnosis ranged from 6 to 127 days. The appraisal interval was the longest for almost all children and the diagnostic interval the shortest. Even with some knowledge of T1D, it took many parents several weeks of a complex cyclical and iterative decision-making process and often a physical trigger, such as weight loss, to decide to consult a healthcare professional. By that stage, many had already made or suspected the diagnosis of T1D themselves. Five GPs were interviewed. They felt that the main challenges to diagnosing T1D in children were the rarity of the condition coupled with how well most of the children appeared, and the difficulty in obtaining urine or blood samples from children.

Conclusions

This study highlights the difficulties for parents and GPs in recognising the early symptoms of T1D. It suggests that future interventions should be targeted at parents in the appraisal interval and include the importance of timely presentation to a healthcare professional and the differences between types 1 and 2 diabetes. Primary care physicians should also take parental concerns seriously and do urine dipstick tests during the consultation for children with symptoms of T1D.
The impact of the coronary collateral circulation on outcomes in patients with acute coronary syndromes: results from the ACUITY trial
Authors: Meier Pascal , Lansky Alexandra J , Fahy Martin , Xu Ke , White Harvey D , Bertrand Michel E , Mehran Roxana , Stone Gregg W
Published: December 2013

Objective

We sought to assess the prognostic role of collaterals in a large population of patients presenting with an acute coronary syndrome (ACS).

Methods

The coronary collateral circulation was assessed by an independent angiographic core laboratory using the Rentrop Score in patients enrolled in the randomised Acute Catheterization and Urgent Intervention Triage Strategy trial.

Results

The cohort comprised 5412 patients with moderate to high risk ACS. A total of 858 patients (16.0%) had visible collaterals while 4554 patients (84.0%) had no collaterals. After multivariable adjustment, there were no differences in clinical outcomes at 1 year between the groups, including major adverse cardiac events (MACE) (HR 0.94 (95% CI 0.76 to 1.16), p=0.55), mortality (HR 1.03 (0.65 to 1.62), p=0.91), myocardial infarction (MI) (HR 1.07 (0.83 to 1.38), p=0.60) and unplanned target vessel revascularisation (TVR) (HR 0.95 (0.71 to 1.28), p=0.75). Similarly, in the subgroup of patients undergoing percutaneous coronary intervention (PCI), the adjusted HR for major adverse cardiac events was 1.1 (0.76 to 1.61), p=0.595; 0.81 (0.10 to 6.44), p=0.999 for mortality; and 0.86 (0.54 to 1.35), p=0.564 for MI. The risk of unplanned TVR was increased (HR 2.74 (1.48 to 5.10), p=0.004).

Conclusions

In contrast to other studies, this large core laboratory-based analysis does not confirm a beneficial role of visible coronary collateral vessels on clinical outcomes in patients with ACS; the presence of collaterals was even associated with increased mortality in the unadjusted analysis. Collaterals were associated with a higher risk of TVR in patients undergoing PCI, a finding that may not have been fully corrected given confounders and clinical differences between the groups.

Trial registration

ClinicalTrials.gov Identifier: NCT00093158.
Rates of intentionally caused and road crash deaths of US citizens abroad
Authors: Sherry Melissa K , Mossallam Mahmoud , Mulligan Matthew , Hyder Adnan A , Bishai David
Published: December 2013

Context

Currently, little is known about rates of death by cause and country among US travellers. Understanding the risk by cause and country is imperative to risk communication and the development of risk reduction strategies.

Methods

Publicly available data on non-natural deaths of US citizens abroad were gathered from January 2003 to December 2009 from the US Department of State's Department Bureau of Consular Affairs. Traveller information was gathered from the US Department of Commerce Office of Travel and Tourism for the same time period. Rates of death were calculated by dividing the number of non-natural deaths of US citizens abroad by the number of US outbound visits for each country.

Results

A total of 5417 non-natural death events were retrieved between 2003 and 2009 from the US State Department. Intentionally caused death rates ranged from 21.44 per 1 000 000 visits in the Philippines to 0 per 1 000 000 visits in several countries; the majority of countries had fewer than five intentionally caused deaths per 1 000 000 visits. Rates of road traffic crashes were higher than rates of intentionally caused deaths in almost every instance. Thailand had the highest rate of deaths due to road traffic crashes (16.49 per 1 000 000), followed by Vietnam, Morocco and South Africa (15.12 per 1 000 000, 11.96 per 1 000 000 and 10.90 per 1 000 000, respectively). Motorcycle deaths account for most of the heightened risk observed in Thailand and Vietnam.

Conclusions

The leading cause of non-natural deaths in US travellers abroad was road crashes, which exceeds intentional injury as the leading cause of non-natural deaths in almost every country where US citizens travel. Southeast Asia had the highest unintentional injury death rates for US citizens abroad due to the high rates of deaths from motorcycle crashes.
Impacts and prognosis of natural resource development on aquatic biodiversity in Canada’s boreal zone
Authors: Kreutzweiser David , Beall Frederick , Webster Kara , Thompson Dean , Creed Irena
Published: December 2013

Conservation efforts to sustain water resources and aquatic biodiversity in boreal watersheds will require reliable information on the recent status of various indicator species and an improved understanding of the risks to aquatic biodiversity posed by resource development activities. We reviewed the recent state of knowledge on the responses of aquatic biodiversity to forest management, pulp and paper mill effluents, hydroelectric impoundments, mining of minerals and metals, oil sands extractions, and peat mining and offer a prognosis for aquatic biodiversity under each of these environmental stressors. Despite the prevalence of natural resource development in Canada’s largest forest ecosystem, there was a limited amount of published literature on the effects of many of the disturbance types on various indicators of aquatic biodiversity, making it difficult to produce a current and reliable status assessment. Across most of the boreal zone, there is a lack of coordinated, consistent data collection for many of the bioindicators and disturbance types discussed in this review. Forecasting the future state of aquatic biodiversity across the boreal zone is challenged by increasing natural resource development and its interactions with other stressors, especially climate change. The cumulative effects of multiple stressors coupled with resource development activities in boreal watersheds remain largely unknown. More importantly, the ecological thresholds for these cumulative effects (that is, the point at which aquatic ecosystems and their biodiversity cannot recover to a desired state within a reasonable time frame) are also unknown and remain gaps in our knowledge. The recent literature identifies a number of risks to aquatic biodiversity at local (tens of square kilometres) to regional (hundreds of square kilometres) scales associated with natural resource development. There are indications that many of these risks can be minimized by “greener” technologies for resource development and reclamation, practical conservation planning and regulation, and increased stewardship in watershed management, although the effectiveness of many of these measures cannot yet be assessed from the published literature.
IMPACTS OF EXTERNAL SHOCKS ON ASIAN ECONOMIES: PANEL VECTOR AUTOREGRESSIVE REGRESSION WITH LATENT DYNAMIC COMPONENTS APPROACH
Authors: YANG DOO YONG
Published: December 2013

This paper analyzes the effects of external shocks on emerging Asian economies. Since the Asian crisis of 1997–1998, the impact of external shocks on regional economies has grown important in the Asian business cycles as well as in the decision-making process of macroeconomic policies, as emerging Asian economies have become more integrated with the global economy. This paper designs a state-space representation of the panel vector autoregressive model with latent dynamic components in order to show the impulse response function of three external shocks including real income shock, financial shock, and long-term real interest rate shock. This paper finds the external real gross domestic product shock as a dominant one in emerging Asia. The shock has been persistent and has carried long-term effects on emerging Asia before and after the Asian crisis. Second, the external equity shock has also been an important factor influencing the business cycles in the region after the Asian crisis, while the effect has been insignificant before the Asian crisis. Last, the external monetary shock has presumably mitigated effectively by Asia's macroeconomic policy, but it has forced to give up monetary independency in the region.
RESULTS IN Bs PHYSICS AND BOTTOMONIUM SPECTROSCOPY USING THE BELLE ϒ(5S) DATA
Authors: OSWALD CHRISTIAN , PEDLAR TODD K.
Published: December 2013

The Belle experiment at KEK accumulated a 121.4 fb-1 sample of e+e- collisions at the ϒ(5S) resonance. This sample provides ample opportunity for improving the understanding of both the properties of Bs mesons and the spectroscopy of bottomonium states. In this review we describe the recent results obtained from the Belle ϒ(5S) data.
BORN–INFELD GRAVITY REVISITED
Authors: SETARE M. R. , SAHRAEE M.
Published: December 2013

In this paper, we investigate the behavior of linearized gravitational excitation in the Born–Infeld gravity in AdS3 space. We obtain the linearized equation of motion and show that this higher-order gravity propagate two gravitons, massless and massive, on the AdS3 background. In contrast to the R2 models, such as TMG or NMG, Born–Infeld gravity does not have a critical point for any regular choice of parameters. So the logarithmic solution is not a solution of this model, due to this one cannot find a logarithmic conformal field theory as a dual model for Born–Infeld gravity.
NOTE ABOUT HAMILTONIAN FORMALISM FOR GENERAL NONLINEAR MASSIVE GRAVITY ACTION IN STÜCKELBERG FORMALISM
Authors: KLUSOŇ JOSEF
Published: December 2013

In this paper, we try to prove the absence of the ghosts in case of the general nonlinear massive gravity action in Stückelberg formalism. We argue that in order to find the explicit form of the Hamiltonian it is natural to start with the general nonlinear massive gravity action [S. F. Hassan and R. A. Rosen, Phys. Rev. Lett. 108, 041101 (2012), arXiv:1106.3344 [hep-th]]. We perform the complete Hamiltonian analysis of the Stückelberg form of the minimal the nonlinear gravity action in this formulation and show that the constraint structure is so rich that it is possible to eliminate nonphysical modes. Then, we extend this analysis to the case of the general nonlinear massive gravity action. We find the corresponding Hamiltonian and collection of the primary constraints. Unfortunately we are not able to finish the complete analysis of the stability of all constraints due to the complex form of one primary constraint so that we are not able to determine the conditions under which given constraint is preserved during the time evolution of the system.
Local existence of polynomial decay solutions to the Boltzmann equation for soft potentials
Authors: Morimoto Yoshinori , Yang Tong
Published: December 2013

The existence of classical solutions to the Cauchy problem for the Boltzmann equation without angular cutoff has been extensively studied in the framework when the solution has Maxwellian decay in the velocity variable, cf. [6, 8] and the references therein. In this paper, we prove local existence of solutions with polynomial decay in the velocity variable for the Boltzmann equation with soft potential. In the proof, the singular change of variables between post- and pre-collision velocities plays an important role, as well as the regular one introduced in the celebrated cancelation lemma by Alexandre–Desvillettes–Villani–Wennberg [Entropy dissipation and long-range interactions, Arch. Ration. Mech. Anal.  152 (2000) 327–355].
Effective and Robust Query-Based Stemming
Authors: Paik Jiaul H. , Parui Swapan K. , Pal Dipasree , Robertson Stephen E.
Published: December 2013

Stemming is a widely used technique in information retrieval systems to address the vocabulary mismatch problem arising out of morphological phenomena. The major shortcoming of the commonly used stemmers is that they accept the morphological variants of the query words without considering their thematic coherence with the given query, which leads to poor performance. Moreover, for many queries, such approaches also produce retrieval performance that is poorer than no stemming, thereby degrading the robustness. The main goal of this article is to present corpus-based fully automatic stemming algorithms which address these issues. A set of experiments on six TREC collections and three other non-English collections containing news and web documents shows that the proposed query-based stemming algorithms consistently and significantly outperform four state of the art strong stemmers of completely varying principles. Our experiments also confirm that the robustness of the proposed query-based stemming algorithms are remarkably better than the existing strong baselines.
Impulsive and Compulsive Behaviors in Parkinson's Disease
Authors: Averbeck B.B. , O'Sullivan S.S. , Djamshidian A.
Published: December 2013

Impulsive-compulsive behaviors (ICBs) in Parkinson's disease (PD) are a common and devastating side effect of dopamine replacement therapy. In this review we describe the phenomenology, prevalence, and risk factors of patients with PD. Results of behavioral studies assessing the neuropsychological profile of patients with PD emphasize that the ICBs, which are behavioral addictions, are not hedonically motivated. Rather, other factors such as the inability to cope with uncertainty may be triggering ICBs. New insights from functional imaging studies, strengthening the incentive salience hypothesis, are discussed, and therapeutic guidelines for the management of ICBs in PD are given.
The Internship Imbalance in Professional Psychology: Current Status and Future Prospects
Authors: Hatcher Robert L.
Published: December 2013

The internship is an essential part of doctoral training in professional psychology. Most students access internships through the annual match sponsored by the Association of Psychology Postdoctoral and Internship Centers (APPIC). For two decades the match has seen an increasing shortfall of internship positions relative to applicants, exceeding 650 unmatched clinical students as of 2013. Efforts to solve this problem have not met appreciable success. This review discusses the structure of the internship placement process, including and beyond the APPIC match, and identifies the reasons for the failed efforts, which lie principally in the varied standards for an acceptable internship among doctoral programs. Efforts to establish a common standard and the need for a governance structure to enforce whatever standard is agreed upon are discussed. Projections for the future of the placement process and the imbalance are sketched, and links to other issues in the field are briefly reviewed.
TGF-β Activation and Function in Immunity
Authors: Travis Mark A. , Sheppard Dean
Published: December 2013

The cytokine TGF-β plays an integral role in regulating immune responses. TGF-β has pleiotropic effects on adaptive immunity, especially in the regulation of effector and regulatory CD4+T cell responses. Many immune and nonimmune cells can produce TGF-β, but it is always produced as an inactive complex that must be activated to exert functional effects. Thus, activation of latent TGF-β provides a crucial layer of regulation that controls TGF-β function. In this review, we highlight some of the important functional roles for TGF-β in immunity, focusing on its context-specific roles in either dampening or promoting T cell responses. We also describe how activation of TGF-β controls its function in the immune system, with a focus on the key roles for members of the integrin family in this process.
Interaction between gastrocnemius medialis fascicle and Achilles tendon compliance: a new insight on the quick-release method
Authors: Farcy Stevy , Nordez Antoine , Dorel Sylvain , Hauraix Hugo , Portero Pierre , Rabita Giuseppe
Published: December 2013

The insufficient temporal resolution of imaging devices has made the analysis of very fast movements, such as those required to measure active muscle-tendon unit stiffness, difficult. Thus the relative contributions of tendon, aponeurosis, and fascicle to muscle-tendon unit compliance remain to be determined. The present study analyzed the dynamic interactions of fascicle, tendon, and aponeurosis in human gastrocnemius medialis during the first milliseconds of an ankle quick-release movement, using high-frame-rate ultrasonography (2,000 frames/s). Nine subjects performed the tests in random order at six levels of maximal voluntary contraction (MVC) (30% to 80% of MVC). These tests were carried out with the ultrasound probe placed on the muscle belly and on the myotendinous junction. Tendon, muscle fascicle, and aponeurosis length changes were quantified in relation to shortening of the muscle-tendon unit during the first few milliseconds following the release. The tendon was the main contributor (around 72%) to the shortening of the muscle-tendon unit, whereas the muscle fascicle and aponeurosis contributions were 18% and 10%, respectively. Because these structures can be considered in series, the quantified contributions can be regarded as relative contributions to muscle-tendon compliance. These contributions were not modified with the level of MVC or the time range used for the analysis between 10 and 25 ms. The constant contribution of tendon, muscle fascicle, and aponeurosis to muscle-tendon unit compliance may help to simplify the mechanism of compliance regulation and to maintain the important role of tendons in enhancing work output and movement efficiency.
Exact Solutions for (3+1)-Dimensional Potential-YTSF Equation and Discrete Kadomtsev-Petviashvili Equation
Authors: Wang Yan , Wang Zhenhui
Published: December 2013

By employing Hirota bilinear method, we mainly discuss the (3+1)-dimensional potential-YTSF equation and discrete KP equation. For the former, we use the linear superposition principle to get itsNexponential wave solutions. In virtue of some Riemann theta function formulas, we also construct its quasiperiodic solutions and analyze the asymptotic properties of these solutions. For the latter, by using certain variable transformations and identities of the theta functions, we explicitly investigate its periodic waves solutions in terms of one-theta function and two-theta functions.
Aerodynamic Analysis of Cup Anemometers Performance: The Stationary Harmonic Response
Authors: Pindado Santiago , Cubas Javier , Sanz-Andrés Ángel
Published: December 2013

The effect of cup anemometer shape parameters, such as the cups’ shape, their size, and their center rotation radius, was experimentally analyzed. This analysis was based on both the calibration constants of the transfer function and the most important harmonic term of the rotor’s movement, which due to the cup anemometer design is the third one. This harmonic analysis represents a new approach to study cup anemometer performances. The results clearly showed a good correlation between the average rotational speed of the anemometer’s rotor and the mentioned third harmonic term of its movement.
Reduced Latency in the Metastatic Niche Contributes to the More Aggressive Phenotype of LM8 Compared to Dunn Osteosarcoma Cells
Authors: Arlt Matthias J. E. , Banke Ingo J. , Bertz Josefine , Ram Kumar Ram Mohan , Muff Roman , Born Walter , Fuchs Bruno
Published: December 2013

Metastasis is the major cause of death of osteosarcoma patients and its diagnosis remains difficult. In preclinical studies, however, forced expression of reporter genes in osteosarcoma cells has remarkably improved the detection of micrometastases and, consequently, the quality of the studies. We recently showed that Dunn cells equipped with alacZreporter gene disseminated from subcutaneous primary tumors as frequently as their highly metastatic subline LM8, but only LM8 cells grew to macrometastases. In the present time-course study, tail-vein-injected Dunn and LM8 cells settled within 24 h at the same frequency in the lung, liver, and kidney of mice. Furthermore, Dunn cells also grew to macrometastases, but, compared to LM8, with a delay of two weeks in lung and one week in liver and kidney tissue, consistent with prolonged survival of the mice. Dunn- and LM8-cell-derived ovary and spine metastases occurred less frequently.In vitro, Dunn cells showed less invasiveness and stronger contact inhibition and intercellular adhesion than LM8 cells and several cancer- and dormancy-related genes were differentially expressed. In conclusion, Dunn cells, compared to LM8, have a similar capability but a longer latency to form macrometastases and provide an interesting new experimental system to study tumor cell dormancy.
Basel III and Asset Securitization
Authors: Mpundu M. , Petersen M. A. , Mukuddem-Petersen J. , Gideon F.
Published: December 2013

Asset securitization via special purpose entities involves the process of transforming assets into securities that are issued to investors. These investors hold the rights to payments supported by the cash flows from an asset pool held by the said entity. In this paper, we discuss the mechanism by which low- and high-quality entities securitize low- and high-quality assets, respectively, into collateralized debt obligations. During the 2007–2009 financial crisis, asset securitization was seriously inhibited. In response to this, for instance, new Basel III capital and liquidity regulations were introduced. Here, we find that we can explicitly determine the transaction costs related to low-quality asset securitization. Also, in the case of dynamic and static multipliers, the effects of unexpected negative shocks such as rating downgrades on asset price and input, debt obligation price and output, and profit will be quantified. In this case, we note that Basel III has been designed to provide countercyclical capital buffers to negate procyclicality. Moreover, we will develop an illustrative example of low-quality asset securitization for subprime mortgages. Furthermore, numerical examples to illustrate the key results will be provided. In addition, connections between Basel III and asset securitization will be highlighted.
Optimal Design of the Feeder-Bus Network Based on the Transfer System
Authors: Deng Lianbo , Gao Wei , Fu Yanbing , Zhou Wenliang
Published: December 2013

This paper studied the classic feeder-bus network design problem (FBNDP), which can be described as follows: for the passenger travel demand between rail stations and bus stops on a given urban transit network, it designs the optimal feeder bus routes and frequencies so as to minimize the passengers’ travel expense and the operator’s cost. We extended the demand pattern of M-to-1 in most existing researches to M-to-M. We comprehensively considered the passenger travel cost, which includes the waiting and riding cost on the bus, riding cost on rail, and transfer cost between these two transportation modes, and presented a new genetic algorithm that determines the optimal feeder-bus operating frequencies under strict constraint conditions. The numerical examples under different demand patterns have been experienced and analysed, which showed the robustness and efficiency of the presented algorithm. We also found that the distribution pattern of the travel demand has a significant influence on the feeder-bus network construction.
Toxicity of Superparamagnetic Iron Oxide Nanoparticles on Green AlgaChlorella vulgaris
Authors: Barhoumi Lotfi , Dewez David
Published: December 2013

Toxicity of superparamagnetic iron oxide nanoparticles (SPION) was investigated onChlorella vulgariscells exposed during 72 hours to Fe3O4(SPION-1), Co0.2Zn0.8Fe2O4(SPION-2), or Co0.5Zn0.5Fe2O4(SPION-3) to a range of concentrations from 12.5 to 400 μg mL−1. Under these treatments, toxicity impact was indicated by the deterioration of photochemical activities of photosynthesis, the induction of oxidative stress, and the inhibition of cell division rate. In comparison to SPION-2 and -3, exposure to SPION-1 caused the highest toxic effects on cellular division due to a stronger production of reactive oxygen species and deterioration of photochemical activity of Photosystem II. This study showed the potential source of toxicity for three SPION suspensions, having different chemical compositions, estimated by the change of different biomarkers. In this toxicological investigation, algal modelC. vulgarisdemonstrated to be a valuable bioindicator of SPION toxicity.
Progression of Luminal Breast Tumors Is Promoted by Ménage à Trois between the Inflammatory Cytokine TNFαand the Hormonal and Growth-Supporting Arms of the Tumor Microenvironment
Authors: Weitzenfeld Polina , Meron Nurit , Leibovich-Rivkin Tal , Meshel Tsipi , Ben-Baruch Adit
Published: December 2013

Breast cancer progression is strongly linked to inflammatory processes, aggravating disease course. The impacts of the inflammatory cytokine TNFαon breast malignancy are not fully substantiated, and they may be affected by cooperativity between TNFαand other protumoral mediators. Here, we show that together with representatives of other important arms of the tumor microenvironment, estrogen (hormonal) and EGF (growth-supporting), TNFαpotently induced metastasis-related properties and functions in luminal breast tumor cells, representing the most common type of breast cancer. Jointly, TNFα+ Estrogen + EGF had a stronger effect on breast cancer cells than each element alone, leading to the following: (1) extensive cell spreading and formation of FAK/paxillin-enriched cellular protrusions; (2) elevated proportion of tumor cells coexpressing high levels of CD44 andβ1 and VLA6; (3) EMT and cell migration; (4) resistance to chemotherapy; (5) release of protumoral factors (CXCL8, CCL2, MMPs). Importantly, the tumor cells used in this study are known to be nonmetastatic under all conditions; nevertheless, they have acquired high metastasizing abilitiesin vivoin mice, following a brief stimulation by TNFα+ Estrogen + EGF. These dramatic findings indicate that TNFαcan turn into a strong prometastatic factor, suggesting a paradigm shift in which clinically approved inhibitors of TNFαwould be applied in breast cancer therapy.
Optimizing Route for Hazardous Materials Logistics Based on Hybrid Ant Colony Algorithm
Authors: Wang Haixing , Xiao Guiping , Wei Zhen
Published: December 2013

Optimizing Route for Hazardous Materials Logistics (ORHML) belongs to a class of problems referred to as NP-Hard, and a strict constraint of it makes it harder to solve. In order to dealing with ORHML, an improved hybrid ant colony algorithm (HACA) was devised. To achieve the purpose of balancing risk and cost for route based on the principle of ACA that used to solve TSP, the improved HACA was designed. Considering the capacity of road network and the maximum expected risk limits, a route optimization model to minimize the total cost is established based on network flow theory. Improvement on route construction rule and pheromone updating rule was adopted on the basis of the former algorithm. An example was analyzed to demonstrate the correctness of the application. It is proved that improved HACA is efficient and feasible in solving ORHML.
Survey of the DASH7 Alliance Protocol for 433 MHz Wireless Sensor Communication
Authors: Weyn Maarten , Ergeerts Glenn , Wante Luc , Vercauteren Charles , Hellinckx Peter
Published: December 2013

433 MHz is getting more attention for Machine-to-Machine communication. This paper presents the DASH7 Alliance Protocol, an active RFID alliance standard for 433 MHz wireless sensor communication based on the ISO/IEC 18000-7. First, the major differences of 433 MHz communication compared to more frequently used frequencies, such as 2.4 GHz and 868/920 MHz are explained. Subsequently, the general concepts of DASH7 Alliance Protocol are described, such as the BLAST networking topology and the different OSI layer implementations, in a top-down method. Basic DASH7 features such as the advertising protocol, ad-hoc synchronization and query based addressing are used to explain the different layers. Finally, the paper introduces a software stack implementation named OSS-7, which is an open source implementation of the DASH7 alliance protocol used for testing, rapid prototyping, and demonstrations.
On Linear Difference Equations for Which the Global Periodicity Implies the Existence of an Equilibrium
Authors: Győri István , Horváth László
Published: December 2013

It is proved that any first-order globally periodic linear inhomogeneous autonomous difference equation defined by a linear operator with closed range in a Banach space has an equilibrium. This result is extended for higher order linear inhomogeneous system in a real or complex Euclidean space. The work was highly motivated by the early works of Smith (1934, 1941) and the papers of Kister (1961) and Bas (2011).
Albert Camus: su experiencia y su teoria de la tragedia
Authors: Cassagne Inés de
Published: December 2013

Camus encuentra en el género trágico un cauce adecuado para su experiencia. Esta experiencia, cuya savia alimenta todos sus frutos literarios, es la del doble rostro de la existencia humana en este mundo. A ella responde como artista, y como hombre, en el perfecto equilibrio del “rechazo” y el “consentimiento”. Cuando decide en 1956 publicar su primer testimonio juvenil, El revés y el derecho, al prologarlo, confirma aquel testimonio y expone su decisión artística. Cambiar la vida, sin cambiar el mundo. Cambiar la miseria, sin cambiar el sol, la belleza, mediante la fórmula de equilibrio de “rechazo” y “consentimiento”.Esta fórmula no podría cuajar de modo acabado sino en el cauce de la tragedia, herencia de los griegos. Para quien revive la experiencia del destino humano en un mundo sin más allá, la sola trascendencia posible de perfectibilidad sólo puede darse en el espacio ideal del arte, único capaz de acoger dramáticamente la tensión entre los polos contrastantes la vida que colma y a la vez decepciona y pasa.
"Leiam Camus, leiam verdadeiramente" Entrevista com Agnès Spiquel, presidente da Sociedade de Estudos Camusianos
Authors: Geske Samara Fernanda A. O. de Lócio e Silva , Araújo Raphael Luiz de
Published: December 2013

Entrevista com Agnès Spiquel, presidente da Sociedade de Estudos Camusianos
Cem anos de Albert Camus
Authors: Pino Claudia Amigo , De Araújo Raphael Luiz , Geske Samara
Published: December 2013

Editorial n.10 "Universo Camus"
Da crise de uma morte aos impasses da ressurreição
Authors: Ielpo Rodrigo
Published: December 2013

A "morte do autor", anunciada por Roland Barthes no final dos anos sessenta, caminhou lado a lado com a "morte" do sujeito, tal como concebido pela tradição humanista. Ainda que nas últimas décadas alguns críticos tenham aludido a um "retorno ao sujeito", a dramatização da inscrição do Eu em alguns textos aponta para uma impossibilidade de resposta entre morte e ressurreição. Este artigo pretende investigar a necessidade de uma formulação teórica do que parece configurar-se como uma passagem para um regime de autoria em que a oposição mencionada não parece funcionar.
A indeterminação em Esaú e Jacó - Problemática de uma literatura exterior
Authors: Pinheiro Tiago Guilherme
Published: December 2013

Este artigo pretende esboçar uma análise da construção de uma literatura exterior dentro da obra de Joaquim Maria Machado de Assis e de como essa estratégia textual se problematiza a partir das novas relações que estabelece entre autor, narrador e leitor.
As metamorfoses da pedra : prolegômenos à crítica de Pedra do Sono , de João Cabral de Melo Neto , da 3ª para a 4ª edição
Authors: Santos Acácio Luiz
Published: December 2013

Este trabalho investiga as transformações mais significativas do primeiro volume de poemas de João Cabral de Melo Neto, Pedra do sono, da terceira para a quarta edição, procurando, assim, contribuir para sua exegese e auxiliar posteriores pesquisas de crítica textual sobre ele.
Salomé, a musa do fim-do-século
Authors: Gomes Álvaro Cardoso
Published: December 2013

Tendo por base o poema “Salomé”, da autoria de Mallarmé, o artigo analisa a personagem, procurando entendê-la como verdadeiro topus do fim-do-século, graças ao modo como ela aniquila o homem com seu erotismo gelado. Salomé, nesse sentido, é vista mais como um símbolo, a representação de uma época do que uma figura histórica ou mítica.
As aventuras de Telêmaco: História crítica e releituras
Authors: Brito Tarsilla Couto de
Published: December 2013

Um dos problemas permanentes para a interpretação de As aventuras de Telêmaco é sua classificação: espelho de príncipes, conto filosófico, romance, idílio ou epopéia são alguns dos gêneros atribuíveis ao texto de Fénelon. O presente artigo pretende retomar a questão, apresentando a história de crítica e de edição do Telêmaco e dando continuidade a uma vertente de leitura que surgiu no final do século passado, aquela fundamentada no pensamento utópico.
Proust: la recherche du sens
Authors: Agostinho Larissa Drigo
Published: December 2013

Nosso objetivo é esboçar uma interpretação sobre o sentido de uma célebre frase proustiana segundo a qual a verdadeira vida é a literatura, no que concerne a relação entre experiência e criação literária. Para isso examinaremos alguns conceitos proustianos relacionados à sensação, à impressão e à inteligência como a memória involuntária, a ideia de essência e as interpretações suscitadas na crítica literária, com o intuito de estabelecer uma interpretação do que seriam, em linhas gerais, a literatura e a criação literária segundo Proust.
O Dissecador de Passarinhos e a Idade da Razão – Reflexões sobre a relação entre recepção e criação na produção literária
Authors: Santos Kleber Pereira dos
Published: December 2013

Partindo de estudo anterior sobre a importância do intertexto sartriano durante a escrita e reescrita do romance O Ventre, de Carlos Heitor Cony, este artigo propõe-se refletir sobre a relação entre recepção e criação na produção literária.