bluuebunny/crossref_metadata_2025 huggingface dataset:
Consensus document on exclusion diets in irritable bowel syndrome (IBS)
Authors: Casellas Francesc , Burgos Rosa , Marcos Ascensión , Santos Javier , Ciriza-de-los-Ríos Constanza , García-Manzanares Álvaro , Polanco Isabel , Puy-Portillo María , Villarino Antonio , Lema-Marqués Beatriz , Vázquez-Alférez M.ª del Carmen
Published: December 2018

This paper summarizes the contents of a consensus document on exclusion diets in irritable bowel disease that was developed by a task force from SEPD, FEAD, SENPE, FESNAD, SEÑ, SEEN, SEGHNP, SEDCA and ADENYD. The complete document is available at the FEAD and in SENPE websites. Irritable bowel syndrome is a highly prevalent functional digestive disorder where, in addition to drugs, therapy includes diet and acquisition of healthy habits as basic elements for its control. In order to facilitate dietary counseling for these patients in daily practice, the present consensus document on the role of exclusion diets was developed. To this end, consensus opinions were collected from various experts in the national scientific societies aiming at establishing recommendations applicable to the health care of patients with irritable bowel syndrome.
The Relationship Between Self-Efficacy on Teaching Reading Comprehension Skills among Secondary Schools Teachers in Telangana State, India
Authors: Begum Farhath Unissa , Hamzah Mohd Hilmi Bin
Published: December 2018

Over the years, the quality and effectiveness of teaching have been the priority of the Indian government in improving the education sector, particularly the teaching reading comprehension skill among teachers.  This paper investigates the relationship between self-efficacy on teaching reading comprehension skills among secondary school teachers in Telangana State, India.  The study is a quantitative research of the survey type.  The total of 2019 teachers of government owned secondary schools constituted the population, simple random sampling technique was used to select 192 teaching English language across all secondary schools in the state.  Two sets of questionnaire title Teacher self-efficacy Scale (TSES) and Teaching Reading Comprehension Skills which was adapted from Progress International Literacy Study (PIRLS) were used to seek information from English teachers.  Pearson product moment correlation statistics was used to analysis the data and the results of the findings revealed that there is a statistically significant relationship between self-efficacy and teaching reading comprehension skill among secondary school teachers in Telangana State India.  Therefore, this study recommends that the school management should implement a policy that will increase teacher efficacy to improve students reading comprehension and to design more effective reading course and activities in the classroom.
Sistem Informasi Stok Gudang Koperasi Menggunakan Supply Chain Management
Authors: Khusna Arfiani Nur , Nugraha Fahmi Ardhi
Published: December 2018

The cooperative is faced with the problem of how to keep the availability of goods in the warehouse sufficient, not experiencing upperstock or understock in the stock inventory system. The Supply Chain Management approach can help overcome the problem of availability of goods by integrating suppliers efficiently. The study aims to produce information about the stock of goods and the number of orders for the next period so that it can make a suitable budget plan. Collecting data is the first step and then designing the pattern of supply chain management flow, supply chain management strategies include the use of pareto ABC classification to give priority to supervision of inventory and determination of purchase points by calculating Economy Order Quantity (EOQ), process flow, implementation and testing. The system produces goods stock information that is able to provide accurate information about the remaining stock of goods in the warehouse along with calculation calculations for the purchase of each item at an economical price and amount, for the determination of product reorder time (Reorder Point), the average product lead time is 2 days, the usage rate per day for rice is 0.34 and the safety stock of rice is 20 sacks so that if the rice has reached the 3 point sack then the cooperative must re-order. The test results using usability test showed that 66.66% of the questions were able to be answered by the respondents and the test results between 65-84% were declared good so that the application was feasible and usable.
An applicability test of the use of deposit-refund system for managing water-sachet litter in Ilorin, Nigeria
Authors: Ilias Biala Musa , Aregbeyen Omo
Published: December 2018

This study used both quasi-experiment and contingent valuation survey to explore the applicability of deposit-refund system (DRS) to water-sachet litter management in Nigeria. In the experiment, a DRS was established to incentivize the participants to return emptied sachets of water. A contingent valuation survey of 454 sachet-water consumers selected using quasi-systematic sampling technique was conducted. Experimental results showed that the number of sachets returned by the experimental group – those subjected to DRS – was significantly greater than that of the comparison group – those not subjected to DRS. Logit regression results showed that refund size increased the odds of returning sachets by 42.0%. Increasing the redemption time decreased the odds of turning in sachets by about 16.0%. A one-minute increase in the time spent on redemption would result in about 2.4% decrease in the probability that participants would comply. Income decreased the odds of compliance by about 31.0%, while age reduced the odds of compliance by about 2.2%. These results imply that the DRS reduced water-sachet littering in the study area, and that income, refund amount, redemption time, age and perceived effectiveness of DRS influenced consumers’ compliance with DRS. Hence, an appropriate motivating DRS would reduce litter and its attendant problems, such as hygiene, plastic pollution, flooding, aesthetic loss, non-naturally degradable toxic compounds, degradation of natural habitat ant its endangered species. The government should, therefore, implement a DRS and set up recycling plants, or encourage private recycling firms, in order to accommodate used sachets that would end up piling up.
Methodological approaches to investment property valuation
Authors: Fomina Olena , Moshkovska Olena , Prokopova Olena , Nikolenko Nataliya , Slomchynska Svitlana
Published: December 2018

Increase in number of the investment property items available in both domestic and international markets, present-day European integration processes, as well as existing differences in statutory provisions in force (controversial essentials of the investment property identification as an asset and ambiguity of implementation of the methodological approaches to the investment property valuation) have stipulated the need for improvement of the hierarchy of the investment property item fair value recognition and measurement criteria. Proposed identification methods will contribute into amplification of the synergy effect of the investment property item accounting and management due to improvement of quality and fairness of the information data on certain assets of the establishment. Methodology for the investment property valuation and changed value reporting format were worked out based upon critical analysis of the scientific professionals’ main approaches to the investment property fair value measurement as provided for by statutory requirements to disclosure of the asset related information. Findings made and recommendations worked out on consideration of the harmonized indicator system implementation have thereafter found the practical use in the investment property item management efficiency assessment model.
The analysis of influence of motivation and organizational commitment on employees’ performance in Telkom Kandatel Gorontalo Province
Authors: Rahman Rahim Abdul , Jam’an Andi
Published: December 2018

Every organization is required to be in a conducive condition in order to produce optimal performance to serve the community. The successfulness of an organization in many activities was based on technological advantages, fund avalaibility, facilities and human capital. It demanded that every organization of the company must improve its competence in terms of human resources. This research was explanatory research with a quantitative approach that aimed to:1) analyze the effect of motivation on organizational commitment;2) analyze the effect of motivation on employees’ performance;3) analyze the effect of organizational commitment on employees’performance;4) analyze the effect of motivation on employees’ performance through organizational commitment.
The study was conducted at the Regional Service Office of PT Telkom Kandatel Gorontalo Province with the total sample of 45 people, the sampling technique used was saturated sampling (census). Primary data collected using the questionnaires were then processed and analyzed using Structural Equation Modeling (SEM). The results of the study indicated that:1) motivation had a significant positive effect on organizational commitment;2) motivation did not have a significant effect on employees’ performance;3) organizational commitment had a significant positive effect on employees’ performance;4) motivation had a significant positive effect on employees’ performance through organizational commitment of PT Telkom Kandatel Gorontalo Province employees.
Religious feeling, morality and ethical feelings: the case study on Indonesia
Authors: Lukviarman Niki , Maruf  , Syafrizal  , Hamidi Masyhuri
Published: December 2018

There is no guarantee that people will follow their professional code of ethics. Large number of violation occurred in almost every organization. In this study we argued that commitment toward code of ethics, which is related to ethical feelings, is imperative to predict whether a person will obey their professional code. This study predicted that commitment to the code of ethics is determined by individual morality (i.e. moral judgment and moral maturity), and religious feeling. The survey was conducted through online questionnaire to Indonesian employees from various sectors and undergraduate students. The analysis revealed that moral judgment cannot predict commitment toward code of ethics. The result showed that religious feeling and moral maturity have positive association with commitment to code of ethics. In addition, these two concepts also produced favorable effect on moral judgment. Discussion, implication, and limitation are provided in the final part of article.
Effect of sodium bicarbonate residue on some characteristics of processed meat products
Authors: Akbari-adergani Behrouz , Akbari-adergani Behrouz , Sallak Neda , Sallak Neda , Jahed khaniki Gholamreza , Jahed khaniki Gholamreza , Rastkari Noushin , Rastkari Noushin , Sadighara Parisa , Sadighara Parisa
Published: December 2018

Using sodium bicarbonate (SB) in cooking meat products is a controversial subject. The aim of this study was to estimate an effect of different SB concentrations on the quality characteristics and organoleptic properties of meat in Kubideh Kebab, an Iranian popular meat product. Ground meat was divided into four groups (a, b, c, and d). After that, SB was added in ratio 0.25, 0.50, 1.00, and 2.00 g/kg respectively. A sample without SB was considered as a blank sample. The Kebab samples were prepared and cooked properly at 350°C for 4–6 minutes and at 450°C for 2–4 minutes. A significant difference was observed in the pH values and the cooking loss between the blank sample and those Kebab samples that were cooked at 350°C and 450°C and pre-treated with SB in the amount of 0.25–2.00 g per 1 kg of meat (P < 0.05). The amount of residual bicarbonate ions increased significantly in the cooked Kebab samples at both treatment temperatures in the a-d group in comparison with the blank sample, as well as between the groups (P = 0.00). The organoleptic properties did not change in the a-d groups in comparison with the blank sample.
Optimisation of a process for cocoa-based vermicelli
Authors: Singh Jyoti , Singh Jyoti , Kalyan Krishna , Kalyan Krishna , Yikona Abigail , Yikona Abigail , Sen Sourav , Sen Sourav , Kaur Sawinder , Kaur Sawinder , Gat Yogesh , Gat Yogesh , Kaur Navneet , Kaur Navneet , Rasane Prasad , Rasane Prasad
Published: December 2018

Due to its health promoting properties owing to a high phenolic content and sensory acceptability, cocoa has gained interest as an additive of choice in many food products. The purpose of this study was to incorporate cocoa powder (CP) in vermicelli. Different proportions of cocoa powder (5, 10, 15 and 20%) were prepared by mixing it into a blend of wheat flour and rice flour (60:40) as base ingredients. The quality parameters, including nutritional characteristics, antioxidant activity, cooking and functional properties, and sensory acceptability, were studied. The nutritional profiling showed a significant (p < 0.05) increase in the protein, fat, ash, and carbohydrate alongside a significiant decrease in the moisture content. Similarly, an antioxidant activity increased significantly at p < 0.05, with the increase of cocoa powder concentration. It can be concluded that vermicelli with the 10% cocoa powder incorporated was the best treatment since it was rated as the highest in overall acceptability compared to the other formulations. The bulk density, cooked weight, cooking time, gruel solid loss, and water absorption capacity of samples with 10% cocoa powder were 0.714 g/cm3, 11.56 g, 7.21 min, 0.47 g/100 g, and 146%, respectively. The energy value of the optimised cocoa-based vermicelli was 375 kcal/100g of sample.
Prospects of using extremely low doses of physical factors impact in food biotechnology
Authors: Danilchuk Tatiana , Danilchuk Tatiana , Ganina Vera , Ganina Vera
Published: December 2018

The paper deals with urgent issues of development of resource-saving methods of biotechnological processes intensification. The main purpose of the work is to show the efficiency of using extremely low doses of physical factors impact in food biotechnology. Acoustic and electric treatment was in various modes. Impact capacity did not exceed 10-4 W/kg. The duration of exposure ranged from 5 to 15 min. Barley grains enzymes and lactic acid microorganisms were subjected to treatment. Impact of vibration as a physical factor, its frequency is considered as a priority in controlling growth and biochemical processes in biological objects. Impact frequency in the range of 50–10000 Hz influences the activity of hydrolytic enzymes in bimodal way. It is presented in the article. The coincidence of the frequency ranges of the maximum activity of enzymes in the model reactions with the ones in the grain of barley under the treatment of alternating current and sound is noted. Improvement of all indexes of germinating barley and improvement of the quality of the finished malt were observed in these ranges. Low-intensity acoustic treatment at a frequency of 2000 Hz contributed to an increase in β-galactosidase activity of the CT-95 Str. thermophilus strain. Selected ST-95 Str. thermophilus strain was used in the starter composition for the experimental sample production of fermented melted milk. The fermentation process intensification was observed. The lactose content of this product is 30% less in comparison with the feedstock. The use of traditional starter without a selected strain can reduce the lactose content by an average of 7.5%. The results of biotechnological processes modification by means of the treatment of enzymes and extremely low doses of physical factors impact used in meat technologies are observed. Thus, the prospects of using low-intensity physical effects of vibration in the development of innovative food technologies are substantiated. It is also promising to use these technologies in making absolutely new food products with different qualities.
Intensification of thermal and rheological processes in a scraped-surface apparatus
Authors: Aret Valdur , Aret Valdur , Kremenevskaya Marianna , Kremenevskaya Marianna , Krupoderov Aleksey , Krupoderov Aleksey , Sosnina Olga , Sosnina Olga , Chibiryak Valentina , Chibiryak Valentina , Sazonov Vasily , Sazonov Vasily
Published: December 2018

The operation parameters of a special heat exchange scraped-surface apparatus ware studied and mathematically described in the article. The feature of the apparatus was the use of perforated cleaning devices in order to increase the turbulence of a product. The developed device can be used in the dairy, meat, and fat and oil industry to cool cream, animal fats, margarine emulsions, cooking fats, and other viscous food products. The increase in the productivity of the apparatus was achieved as a result of the more intensive mixing of the cleaned wall layers with the bulk of the cooled product due to the presence of cylindrical holes in the slats with a diameter of at least

0.05–0.1 of the diameter of the working cylinder. As a result of processing experimental data on heat exchange taking into account energy dissipation, a calculated criterial heat exchange equation for the nonisothermal motion of products and their different flows – laminar and transient – was obtained explicitly. In addition, the article considers the effect of starting modes on the operation of apparatus with mixing devices. These data can make it possible to take into account the possible deviations of parameters caused by nonsteady operating modes. On the basis of the data obtained, we have proposed assumptions about the degree of impact of viscosity and inertia in the considered range of parameters on a starting mode. The results of the study are relevant since they allow us to intensify the thermal processes in this type of common apparatus by 10–12%.
Sports and energy drinks
Authors: Diel Friedhelm , Diel Friedhelm , Khanferyan Roman , Khanferyan Roman
Published: December 2018

Presently, sports and energy drinks are widely spread not only among athletes, but also among ordinary people of different ages. The purpose of these beverages is to effectively compensate for the loss of water, energy and electrolytes in the human body before or after some exhausting activities. A questionnaire survey on energy drinks conducted in all eight federal districts of the Russian Federation shows that the younger groups of the Russian population (aged 12–17 and 18–30) drink tonic beverages more often than the older groups (aged 31–45 and 45–60). Further, a recent rise in unreasonable consumption of sports and energy drinks among teenagers may lead to various diseases: obesity, type 2 diabetes, heart disease and tooth enamel erosion. Finally, the authors analyse the composition of energy beverages and thoroughly describe each of their main components (L-carnitine, creatine, caffeine, taurine, and juice-containing products). These components are used by athletes due to their effects: L-carnitine helps reduce the signs of physical and mental overstrain, and stimulates working capacity; creatine improves endurance and anaerobic activity; caffeine raises aerobic endurance by increasing the oxidation of fats, thereby helping preserve glycogen in the muscles; taurine plays an important role as an antioxidant protector in the regulation of Ca++ transport, and as a regulator of osmotic pressure in the tissues.
Analysis of myofibrillar and sarcoplasmic proteins in pork meat by capillary gel electrophoresis
Authors: Grujić Radoslav , Grujić Radoslav , Savanović Danica , Savanović Danica
Published: December 2018

Myofibrillar and sarcoplasmic proteins were extracted from pork meat (M. Longissimus dorsi) and then separated by capillary gel electrophoresis (CGE). Migration time and peak areas of individual protein molecules in the electropherogram were analysed. The electropherograms obtained after the separation of myofibrillar proteins contained

53 well-separated peaks, of which the following were identified: thymosin, myosin light chain-3 (MLC-3), myosin light chain-2 (MLC-2), troponin C, troponin I, myosin light chain-1 (MLC-1), tropomyosin 1, tropomyosin 2, troponin T, actin, desmin, troponin, C protein, and myosin heavy chain (MHC). The relative concentration of the identified myofibrillar proteins was 74.5%. Of the 56 separated sarcoplasmic proteins the following were identified: myoglobin, myokinase, triosephosphate isomerase, phosphoglycerate mutase, lactate dehydrogenase, glyceraldehyde phosphate dehydrogenase, aldolase, creatine kinase, enolase, phosphoglucose isomerase, pyruvate kinase, phosphoglucomutase, and phosphorylase b. The relative concentration of the identified sarcoplasmic proteins was 83.6% of all sarcoplasmic proteins extracted from the pork meat.
Informational support as an element of state control of agriculture
Authors: Bychkova Svetlana , Bychkova Svetlana , Zhidkova Elena , Zhidkova Elena , Eliashev Dmitrii , Eliashev Dmitrii
Published: December 2018

This article substantiates the importance of informational support in the agricultural sector for controlling authorities and for agro-industrial organisations in enhancing their monitoring and competitive strategies. It identifies specific features of the agricultural sector that determine its needs for information, namely its dependence on climatic conditions and the state of natural resources available to economic entities, a large territorial expanse, the location of major production facilities in rural areas, the development of interregional and international contacts, and an active growth of agricultural exports. By studying the current regulatory and legal database of the Russian Federation, the authors established the regulatory framework of a state information system and identified its key data groups. Finally, the paper looks at those information resources which were created by the federal authorities and regional bodies in the Northwestern and Siberian Federal Districts, reflecting the tasks of state informational support in agriculture.
Economic effect of innovative flour-based functional foods production
Authors: Lobanov Vladimir , Lobanov Vladimir , Slepokurova Yuliya , Slepokurova Yuliya , Zharkova Irina , Zharkova Irina , Koleva Tatʹyana , Koleva Tatʹyana , Roslyakov Yuriy , Roslyakov Yuriy , Krasteva Ana , Krasteva Ana
Published: December 2018

The article presents the analysis of economic effect for the innovative flour-based functional foods production incorporation. Based on the analysis of the current state and prospects for the bakery industry development, the authors propose to expand the range of flour-based foods meant for dietary preventive and dietary therapeutic nutrition using diversification methods. For this, they used alternative recipe ingredients of plant origin, such as amaranth seeds, lentil and lupine seeds, chufa, and carob beans. The innovative technologies improve the chemical composition and consumer characteristics of the foods, provide meeting the market requirements, and increase the efficiency of financial and material resources, which, as a result, facilitates the food competitiveness and leads to the bakery industry effective development. We propose to evaluate the economic effect of innovative foods by determining the retail price and profit with a minimum 10% cost effect. The calculations of economic indicators for traditional and new flour-based foods are presented. Estimated economic efficiency of 1 tonne bakery foods for the standard and high-protein diets (according to therapeutic nutrition diet classification) is 5,030–10,740 rbls, flour confectionary foods – 11,022 rbls, gluten-free breads – 7,625–16,990 rbls, depending on the constituents and bakery technology. The results provide strong evidence of economic effect and the advantages of functional flour-based foods introduction.
Investigation of the water quality of daily used surface-sources for drinking and irrigation by the population of Segou in the center of Mali
Authors: Toure Amadou , Wenbiao Duan , Keita Zakaria , Dembele Abdramane
Published: December 2018

This study evaluates the quality and pollution status of source surface waters in Segou, Mali. The nature, sources, and extent of pollution of Comatex Stream, Cerfitex Pond, and Sonikoura River were studied for a period of twelve months (July 2016–June 2017). Analysis included 209 water samples collected from eleven different locations in the study area. Laboratory and field analysis were realized using the standard methods and concerned eleven parameters including four physicals, six chemicals and one bacteriological. Also, organoleptic parameters were observed. Most of the average values of parameters addressing the quality of water were significantly higher (P < 0.05) in both the stream and river compared to the pond. Fecal coliform counts (FCC) were not in significant correlation with the temperature; pH and turbidity; but had a significant and positive correlation (P < 0.05) with conductivity: total dissolved solids (TDS); total suspended solids (TSS); Cl−; PO4−P; NO3−N and 5-day biochemical oxygen demand (BOD5). Analysis of samples revealed a level of FCC that is above the permissible limit for both drinking water and of fresh vegetable irrigation water. In all, there is a pressing need to inform the public about the state of water bodies and the application of relevant laws regarding the proper treatment of sewage before it is discharged into surface water.
Variability of residual chlorine in swimming pool water and determination of chlorine consumption for maintaining hygienic safety of bathers with a simple mass balance model
Authors: Berg Alvyn P. , Fang Ting-An , Tang Hao L.
Published: December 2018

Trial-and-error chlorination as a conventional practice for swimming pool water disinfection may fail to consistently maintain the pool's residual chlorine within regulatory limits. This study explored the variability of residual chlorine and other common water quality parameters of two sample swimming pools and examined the potential of using a mass balance model for proactive determination of chlorine consumption to better secure the hygienic safety of bathers. A lightly loaded Pool 1 with a normalized bather load of 0.038 bather/m3/day and a heavily loaded Pool 2 with a normalized bather load of 0.36 bather/m3/day showed great variances in residual free and combined chlorine control by trial-and-error methods due to dynamic pool uses. A mass balance model based on chemical and physical chlorine consumption mechanisms was found to be statistically valid using field data obtained from Pool 1. The chlorine consumption per capita coefficient was determined to be 4120 mg/bather. The predictive method based on chlorine demand has a potential to be used as a complementary approach to the existing trial-and-error chlorination practices for swimming pool water disinfection. The research is useful for pool maintenance to proactively determine the required chlorine dosage for compliance of pool regulations.

This article has been made Open Access thanks to the generous support of a global network of libraries as part of the Knowledge Unlatched Select initiative.
Study of fluid flow through a channel deformed by piezoelement
Authors: Nasibullayev I.Sh. , Nasibullaeva E.Sh , Darintsev O.V.
Published: December 2018

The flow of a liquid through a tube deformed by a piezoelectric cell under a harmonic law is studied in this paper. Linear deformations are compared for the Dirichlet and Neumann boundary conditions on the contact surface of the tube and piezoelectric element. The flow of fluid through a deformed channel for two flow regimes is investigated: in a tube with one closed end due to deformation of the tube; for a tube with two open ends due to deformation of the tube and the differential pressure applied to the channel. The flow rate of the liquid is calculated as a function of the frequency of the deformations, the pressure drop and the physical parameters of the liquid.
Determination of the allowable maximum size of the obstacle while dragging a pipeline
Authors: Krioni I.N. , Semenova A.V.
Published: December 2018

In this article, the process of overcoming the stony obstacle while dragging pipeline through the channel is considered. Depending on the size of the duct and the pipeline itself the permissible size of the obstacle that the pipeline can overcome without resting against the upper part of the channel, is considered. To solve this problem, the pipeline is conditionally divided into two sections: the site located up to the obstacle and resting on it, and a free area that is after the obstacle. Directly on the process of dragging through an obstacle are acting the forces and moments which have influence on the pipeline. Starting from the equations of moment equilibrium for different points of the pipeline, and also from the equations of bending beams the value of the obstacle is evaluated.
Indentation of the cylindrical shell in the elastoplastic half-space
Authors: Filippov A.A.
Published: December 2018

The article deals with the problem of pressing the steel cylindrical shell into the elastoplastic half-space having a cylindrical concavity. The calculation and analysis of the stress-strain state of the steel shell and elastoplastic half-space. Given the dependence of the shear half-space, the safety factor and stress state in steel shell from the force pushing the shell in the half-space. The calculations were carried out for three radii of concavities and two types of half-space materials. It was assumed that the elastoplastic half-space obeys the Mohr-Coulomb fracture criterion.
Reduction of partially invariant submodels of rank 3 defect 1 to invariant submodels
Authors: Siraeva D.T.
Published: December 2018

Equations of hydrodynamic type with the equation of state in the form of pressure separated into a sum of density and entropy functions are considered. Such a system of equations admits a twelve-dimensional Lie algebra. In the case of the equation of state of the general form, the equations of gas dynamics admit an eleven-dimensional Lie algebra. For both Lie algebras the optimal systems of non-similar subalgebras are constructed. In this paper two partially invariant submodels of rank 3 defect 1 are constructed for two-dimensional subalgebras of the twelve-dimensional Lie algebra. The reduction of the constructed submodels to invariant submodels of eleven-dimensional and twelve-dimensional Lie algebras is proved.
Self-similar elastic regime of filtration through moving boundary
Authors: Khabirov S.V. , Khabirov S.S.
Published: December 2018

The one-dimensional problem of elastic filtration of fluid through moving boundary is considered. The boundary conditions for invariant problem is introduced. The problem is reduced to overdetermine boundary problem for Veber equation. The exact solutions are obtained. For arbitrary invariant filtration law the relationship between overdetermine invariant boundary conditions is obtained.
Reversal of Novel Anticoagulants in Emergent Surgery and Trauma: A Comprehensive Review and Proposed Management Algorithm
Authors: Palaiodimos Leonidas , Miles Jeremy , Kokkinidis Damianos G. , Barkolias Christos , Jonnalagadda Anil K. , Papaconstantinou Dimitrios , Frountzas Maximos , Misiakos Evangelos P. , Schizas Dimitrios
Published: December 2018

Non-vitamin K oral anticoagulants (NOACs), including dabigatran, rivaroxaban, apixaban, and edoxaban,
are increasingly used for thromboembolism prevention. Contrary to older anticoagulants, such as coumadin,
when antidotes existed and were broadly used in cases of emergent surgery and bleeding, antidotes for NOACs
have not been developed until recently. Moreover, the monitoring of NOAC’s anticoagulant effect varies across
different hospital settings and the absence of a single test that can accurately predict the degree of anticoagulation
achieved increases the uncertainty. These uncertainties often result in management dilemmas for clinicians when
patients who are on NOACs need a reversal of anticoagulation. Until recently, available antidotes for NOACs
included only prothrombin complex concentrate (PCC), activated prothrombin complex concentrate (aPCC) and
recombinant activated factor VII and the less optimal fresh frozen plasma (FFP). Recently though, novel antidotes
for NOACs have been developed, including idarucizumab, which is a monoclonal antibody fragment that binds
dabigatran, and andexanet alfa, a modified decoy form of the activated factor X (FXa) that binds FXa inhibitors
and AT III. Another option, ciraparantag, which is a small molecule that binds to heparin, thrombin inhibitors and
FXa inhibitors, is still in phase I development. In this review, we summarize the current evidence and present the
available bypassing and novel reversal agents. Finally, we propose an algorithm for the management of patients
who take NOACs and present to the emergency department with either trauma and active bleeding or need for
emergent surgery.
Role of Polymers in 3D Printing Technology for Drug Delivery - An Overview
Authors: Jain Ankit , Bansal Kuldeep K. , Tiwari Ankita , Rosling Ari , Rosenholm Jessica M.
Published: December 2018

Background:

3D printing (3DP) is an emerging technique for fabrication of a variety of structures and
complex geometries using 3D model data. In 1986, Charles Hull introduced stereolithography technique that took
advances to beget new methods of 3D printing such as powder bed fusion, fused deposition modeling (FDM),
inkjet printing, and contour crafting (CC). Being advantageous in terms of less waste, freedom of design and
automation, 3DP has been evolved to minimize incurred cost for bulk production of customized products at the
industrial outset. Due to these reasons, 3DP technology has acquired a significant position in pharmaceutical
industries. Numerous polymers have been explored for manufacturing of 3DP based drug delivery systems for
patient-customized medication with miniaturized dosage forms.

Method:

Published research articles on 3D printed based drug delivery have been thoroughly studied and the
polymers used in those studies are summarized in this article.

Results:

We have discussed the polymers utilized to fabricate 3DP systems including their processing considerations,
and challenges in fabrication of high throughput 3DP based drug delivery systems.

Conclusion:

Despite several advantages of 3DP in drug delivery, there are still a few issues that need to be addressed
such as lower mechanical properties and anisotropic behavior, which are obstacles to scale up the technology.
Polymers as a building material certainly plays crucial role in the final property of the dosage form. It is
an effort to bring an assemblage of critical aspects for scientists engaged in 3DP technology to create flexible,
complex and personalized dosage forms.
EH-42: A Novel Small Molecule Induces Apoptosis and Inhibits Migration and Invasion of Human Hepatoma Cells through Suppressing STAT3 Signaling Pathway
Authors: Gong Qi-Zhe , Xiao Di , Gong Gui-Yi , Xu Jian , Wen Xiao-Dong , Feng Feng , Qu Wei
Published: December 2018

Background:

Since signal transducer and activator of transcription 3 (STAT3) is aberrantly activated in hepatocellular carcinoma (HCC) and plays a key role in this tumor progression. Inhibition of the STAT3 signaling pathway has been considered as an effective therapeutic strategy for suppressing HCC development.

Objective:

In this study, we investigated the anti-cancer effects of EH-42 on HCC cells and tried to explain the underlying mechanism.

Methods:

MTT assay, colon formation assay and AnnexinV-FITC/PI double-staining assay were performed to assess the effects of EH-42 on cell growth and survival. Wound healing assay and transwell invasion assay were performed to assess the effects of EH-42 on cell migration and invasion. Western blotting assay was performed to analyze the effects of EH-42 on relative proteins.

Results:

According to the MTT assay, colon formation assay and AnnexinV-FITC/PI doublestaining assay, EH-42 could suppress the growth and induce apoptosis of HCC cells in a dosedependent manner. Further western blotting assay showed that the inhibitory effects of EH-42 on cell growth and survival were caused by activating caspase 3/9, suppressing the phospho-STAT3 (Tyr 705) and downregulating anti-apoptotic proteins like Bcl-2/Bcl-xL. Moreover, migration and invasion abilities of HCC cells were also inhibited by EH-42 in the wound healing assay and transwell invasion assay. The potential mechanism was that EH-42 could inhibit HCC metastasis via reversing epithelial-mesenchymal transition and downregulating the secretion of MMPs.

Conclusion:

Taken together, these findings suggested that EH-42 could be a potential therapeutic agent for HCC treatment.
Application of Topological Descriptors in QSAR Modeling: Substituted Hydrazones Used As a Model System
Authors: Dimova Vesna , Jankulovska Mirjana Stojan
Published: December 2018

Background:

QSAR study of p-substituted aromatic hydrazones was performed to
estimate the quantitative effects of selected topological descriptors on their antimicrobial activity.
None of the hydrazones inhibited the growth of the Aspergillus spp., while the data obtained with
regard to the antifungal activity of the compounds against Candida utilis were insufficient to develop
reliable statistical QSAR models. Therefore, the investigation was focused on developing QSAR
models for predicting the antibacterial activity of the compounds against Bacillus subtilis.

Methods:

A set of substituted hydrazones were tested for their in vitro growth inhibitory activity
against Candida utilis, Bacillus subtilis and Aspergillus niger and the diameter of the inhibition zone
(mm) was measured. The inhibitory activity data, determined in μg/mL, were transformed to the
negative logarithms of molar MICs (log1/CMIC). Using Marvinsketch software package, 28
topological descriptors were calculated. Statistical parameters, such as R2, Sd, F-test, R2
adj, Q, SPRESS,
PSE and Q2, were used to test the quality of the developed two-, three-, four-parametric and higher
QSAR models.

Results and Conclusion:

Statistical evaluation of the data used to test the quality of the obtained
QSAR models indicated that the two-parametric model involving the descriptors Atom Count (AC)
and Maximal Projection Area (MAPA) was statistically significant when all the statistical parameters
were summarized. The two parameters, AC and MAPA, had opposite input in modeling the
antimicrobial activity of the selected hydrazones against Bacillus subtilis.
The Possibility of Therapeutic Drug Monitoring of the Most Important Interactions in Nursing Homes
Authors: Schjøtt Pernille , Šutovská Martina , Schjøtt Jan
Published: December 2018

Background:

Therapeutic drug monitoring is a relevant tool in drug treatment of elderly patients. The aim of this study was to assess the possibility of therapeutic drug monitoring of the most important potential interactions in nursing homes.

Methods:

A material of prescribed drugs to 446 patients in three nursing homes in Bergen, Norway from a single day in March 2016 was analysed. Clinically relevant drug interactions (pharmacodynamic or pharmacokinetic) were identified and classified with Stockley`s Interaction Alerts. The most important interaction among several in each patient were ranked by recommended action > severity > evidence according to Stockley`s. The possibility of therapeutic drug monitoring of drug combinations involved in the most important interactions was retrieved from a database of all laboratories performing clinical pharmacology in Norway (the Pharmacology Portal).

Results:

Two or more drugs were used by 443 (99.3%) of 446 patients. Three-hundred and eightyfour patients (86.1%) had > 1 interaction. About 95% of the most important interactions were pharmacodynamic. In 280 (72.9%) of these interactions, Stockley`s recommended adjust dose or monitoring. Among the 384 most important interactions, 93% involved one drug and 41% involved two drugs available for therapeutic drug monitoring.

Conclusion:

In this pilot study, therapeutic drug monitoring was possible in the majority of the most important interactions in Norwegian nursing homes. This option is of importance since adjust dose or monitoring were frequently recommended actions associated with these interactions.
Metformin and Pregnancy Outcomes: Evidence Gaps and Unanswered Questions
Authors: Gonzalez Claudio D. , Alvariñas Jorge , Bagnes Maria F.G. , Di Girolamo Guillermo
Published: December 2018

Background:

Metformin is sometimes used as an alternative to insulin in gestational
diabetes mellitus (GDM). It is also used to achieve ovulation in polycystic ovary syndrome (PCOS).
Pre-natal exposure to metformin results from its continuation after a successful ovulation in women
with PCOS, its maintenance in women with pre-gestational diabetes or the installation of metformin
in GDM. Little is known about the potential consequences of metformin exposure on pregnancy
outcomes and offspring development. The aim of this review is to summarize the metformin effects
on pregnancy outcomes and offspring development. Gaps in the available evidence and unanswered
questions are also discussed.

Methods:

A comprehensive literature search was carried out to identify eligible studies from
MEDLINE/PubMed, EMBASE and SCIELO databases through 1995 first semester.

Results:

Several factors limit the effect of metformin on embryos. In contrast, placental transport of
metformin is effective allowing for a higher fetal exposure; the impact of this finding remains
unclear. It seems that the interruption of metformin after a pregnancy diagnosis in women with
PCOS is not associated with a higher miscarriage risk and it continuation does not seem to impair
the maternal metabolic prognosis or prevent emerging GDM.

Conclusions:

It seems to have no sense to prolong the use of metformin after a pregnancy diagnosis
in women with PCOS. Patients with GDM may be treated with metformin under on judicious basis,
and a careful attachment to clinical guidelines and regulations is recommended. The long-term
effects of pre-natal exposure to metformin on the offspring remain uncertain.
Mazabraud's Syndrome: A Case Report and Up-To-Date Literature Review
Authors: Vescini Fabio , Falchetti Alberto , Tonelli Veronica , Carpentieri Maria , Cipri Claudia , Cosso Roberta , Kara Elda , Triggiani Vincenzo , Grimaldi Franco
Published: December 2018

Objective:

Mazabraud's syndrome is a rare form of bone fibrous dysplasia associated with
intramuscular myxomas. Fibrous dysplasia, is generally localized to pelvis and femur and it results in a
fragile bone with deformities, pain, pathological fractures and functional impairment. Intramuscular
myxomas, are rare benign mesenchymal neoplasms that exceptionally may evolve to malignant forms.

Methods:

This case report describes a 66-year-old woman with Mazabraud’s Syndrome (MS), characterized
both by monostotic right femur fibrous dysplasia and by a solitary intramuscular myxoma at the
right quadriceps muscle, that underwent a long-term treatment (4 years) with intravenous zoledronic
acid.

Results:

Zoledronic acid therapy rapidly lowered bone pain together with a reduction of intramuscular
myxoma volume, but did not affect the extension of fibrous dysplasia. No adverse effects have been
observed during treatment.

Conclusion:

Highly active bisphosphonates are commonly used for the treatment of bone metabolic
disorders and they are generally well tolerated. Zoledronic acid may represent a promising alternative
to surgical intervention in MS, although its use in rare form of bone fibrous dysplasias is still controversial.
A Modified QuEChERS Extraction and LC-MS/MS Method for the Determination of Pesticide Residues in Curry Leaves (Murraya koenigii)
Authors: Arimboor Ranjith , Menon Karunkara Ramakrishna , Babu Natarajan Ramesh , Chandran Haneesh
Published: December 2018

Background:

Increased consumer demand for curry leaves free from pesticides demands fast and reliable analytical methods for the analysis of pesticide residues.

Objective:

The optimization of a QuEChERS based sample preparation technique with improved analytical accuracy by removing interfering matrix components for LC-MS/MS analysis of pesticide residues from curry leaves.

Methods:

A modified QuEChERS solid phase extraction method was developed and validated for the analysis of 26 pesticides in fresh and dried curry leaves. The effects of the sample preparation steps and column retention time on the matrix suppression of analyte ions were also evaluated.

Results:

Validation parameters were found within an acceptable range. The matrix effect evaluation studies showed that the QuEChERS sample preparation was able to minimize the ion suppression of analytes due to co-eluting matrix of components and that a d-SPE clean up step had major role in reducing matrix effect. The gradient mobile phase with longer retention time for analytes resulted in comparatively lesser matrix effects than the isocratic mobile phase of non-polar nature. Even after the clean up, a considerable number of compounds had more than 20% reduction in their MS response in the gradient mobile phase.

Conclusion:

This study emphasized the need of proper sample clean up before a LC-MS/MS analysis and the usage of matrix matched standards and mobile phase that ultimately results in an appropriate analyte separation in reasonable retention times.
THE EFFECT OF ACUPRESSURE WRISTBAND ON NAUSEA VOMITING IN BREAST CANCER PATIENTS WHO RECEIVED CHEMOTHERAPY
Authors: Fatma Endah Panca
Published: December 2018

Chemotherapy is one of the therapies for cancer patients that cause some side effects, one of them is nausea and vomiting. Nausea and vomiting are still felt by patients even though they take antiemetics. Nausea dan vomiting can cause fluid and electrolyte imbalance. The aim of this study was to analysis the effect of combination acupressure wristband and antiemetic among chemotherapy induced nausea vomiting (CINV) on breast cancer patients. This research used quasi experimental research method, with a pre-post test with the control group. The sampling techniques was consecutive sampling with 25 respondents both in intervention group and control group. In the intervention group had received an acupressure wristband. CINV measured on the second day until fourth day after chemotherapy. Nausea and vomiting score were measured twice a day by a telemonitoring methode by Rhodes Index Nausea, Vomiting and Retching (INVR) questionaire. Data were analyzed by paired t-test, independent t-test, Wilcoxon test and Mann Whitney. The result of this study showed that acupressure wristband significantly reduce the chemotherapy induced nausea and vomit (p value = 0.000). The use of acupressure wristband combined with antiemetic therapy can significantly decreaseÂ  chemotherapy induced nausea and vomiting in breast cancer patients. Acupressure wristband recommended for consideration nursing intervention in treating breast cancer patients who experience nausea and vomiting.