Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms
Authors: Gordon David E. , Hiatt Joseph , Bouhaddou Mehdi , Rezelj Veronica V. , Ulferts Svenja , Braberg Hannes , Jureka Alexander S. , Obernier Kirsten , Guo Jeffrey Z. , Batra Jyoti , Kaake Robyn M. , Weckstein Andrew R. , Owens Tristan W. , Gupta Meghna , Pourmal Sergei , Titus Erron W. , Cakir Merve , Soucheray Margaret , McGregor Michael , Cakir Zeynep , Jang Gwendolyn , O’Meara Matthew J. , Tummino Tia A. , Zhang Ziyang , Foussard Helene , Rojc Ajda , Zhou Yuan , Kuchenov Dmitry , Hüttenhain Ruth , Xu Jiewei , Eckhardt Manon , Swaney Danielle L. , Fabius Jacqueline M. , Ummadi Manisha , Tutuncuoglu Beril , Rathore Ujjwal , Modak Maya , Haas Paige , Haas Kelsey M. , Naing Zun Zar Chi , Pulido Ernst H. , Shi Ying , Barrio-Hernandez Inigo , Memon Danish , Petsalaki Eirini , Dunham Alistair , Marrero Miguel Correa , Burke David , Koh Cassandra , Vallet Thomas , Silvas Jesus A. , Azumaya Caleigh M. , Billesbølle Christian , Brilot Axel F. , Campbell Melody G. , Diallo Amy , Dickinson Miles Sasha , Diwanji Devan , Herrera Nadia , Hoppe Nick , Kratochvil Huong T. , Liu Yanxin , Merz Gregory E. , Moritz Michelle , Nguyen Henry C. , Nowotny Carlos , Puchades Cristina , Rizo Alexandrea N. , Schulze-Gahmen Ursula , Smith Amber M. , Sun Ming , Young Iris D. , Zhao Jianhua , Asarnow Daniel , Biel Justin , Bowen Alisa , Braxton Julian R. , Chen Jen , Chio Cynthia M. , Chio Un Seng , Deshpande Ishan , Doan Loan , Faust Bryan , Flores Sebastian , Jin Mingliang , Kim Kate , Lam Victor L. , Li Fei , Li Junrui , Li Yen-Li , Li Yang , Liu Xi , Lo Megan , Lopez Kyle E. , Melo Arthur A. , Moss Frank R. , Nguyen Phuong , Paulino Joana , Pawar Komal Ishwar , Peters Jessica K. , Pospiech Thomas H. , Safari Maliheh , Sangwan Smriti , Schaefer Kaitlin , Thomas Paul V. , Thwin Aye C. , Trenker Raphael , Tse Eric , Tsui Tsz Kin Martin , Wang Feng , Whitis Natalie , Yu Zanlin , Zhang Kaihua , Zhang Yang , Zhou Fengbo , Saltzberg Daniel ,   QCRG Structural Biology Consortium, Hodder Anthony J. , Shun-Shion Amber S. , Williams Daniel M. , White Kris M. , Rosales Romel , Kehrer Thomas , Miorin Lisa , Moreno Elena , Patel Arvind H. , Rihn Suzannah , Khalid Mir M. , Vallejo-Gracia Albert , Fozouni Parinaz , Simoneau Camille R. , Roth Theodore L. , Wu David , Karim Mohd Anisul , Ghoussaini Maya , Dunham Ian , Berardi Francesco , Weigang Sebastian , Chazal Maxime , Park Jisoo , Logue James , McGrath Marisa , Weston Stuart , Haupt Robert , Hastie C. James , Elliott Matthew , Brown Fiona , Burness Kerry A. , Reid Elaine , Dorward Mark , Johnson Clare , Wilkinson Stuart G. , Geyer Anna , Giesel Daniel M. , Baillie Carla , Raggett Samantha , Leech Hannah , Toth Rachel , Goodman Nicola , Keough Kathleen C. , Lind Abigail L. ,   Zoonomia Consortium, Klesh Reyna J. , Hemphill Kafi R. , Carlson-Stevermer Jared , Oki Jennifer , Holden Kevin , Maures Travis , Pollard Katherine S. , Sali Andrej , Agard David A. , Cheng Yifan , Fraser James S. , Frost Adam , Jura Natalia , Kortemme Tanja , Manglik Aashish , Southworth Daniel R. , Stroud Robert M. , Alessi Dario R. , Davies Paul , Frieman Matthew B. , Ideker Trey , Abate Carmen , Jouvenet Nolwenn , Kochs Georg , Shoichet Brian , Ott Melanie , Palmarini Massimo , Shokat Kevan M. , García-Sastre Adolfo , Rassen Jeremy A. , Grosse Robert , Rosenberg Oren S. , Verba Kliment A. , Basler Christopher F. , Vignuzzi Marco , Peden Andrew A. , Beltrao Pedro , Krogan Nevan J. , Owens Tristan W. , Gupta Meghna , Pourmal Sergei , Titus Erron W. , Azumaya Caleigh M. , Billesbølle Christian , Brilot Axel F. , Campbell Melody G. , Diallo Amy , Dickinson Miles Sasha , Diwanji Devan , Herrera Nadia , Hoppe Nick , Kratochvil Huong T. , Liu Yanxin , Merz Gregory E. , Moritz Michelle , Nguyen Henry C. , Nowotny Carlos , Puchades Cristina , Rizo Alexandrea N. , Schulze-Gahmen Ursula , Smith Amber M. , Sun Ming , Young Iris D. , Zhao Jianhua , Asarnow Daniel , Biel Justin , Bowen Alisa , Braxton Julian R. , Chen Jen , Chio Cynthia M. , Chio Un Seng , Deshpande Ishan , Doan Loan , Faust Bryan , Flores Sebastian , Jin Mingliang , Kim Kate , Lam Victor L. , Li Fei , Li Junrui , Li Yen-Li , Li Yang , Liu Xi , Lo Megan , Lopez Kyle E. , Melo Arthur A. , Moss Frank R. , Nguyen Phuong , Paulino Joana , Pawar Komal Ishwar , Peters Jessica K. , Pospiech Thomas H. , Safari Maliheh , Sangwan Smriti , Schaefer Kaitlin , Thomas Paul V. , Thwin Aye C. , Trenker Raphael , Tse Eric , Tsui Tsz Kin Martin , Wang Feng , Whitis Natalie , Yu Zanlin , Zhang Kaihua , Zhang Yang , Zhou Fengbo , Trinidad Donovan , Agard David A. , Cheng Yifan , Fraser James S. , Frost Adam , Jura Natalia , Kortemme Tanja , Manglik Aashish , Southworth Daniel R. , Stroud Robert M. , Rosenberg Oren S. , Verba Kliment A. , Damas Joana , Hughes Graham M. , Keough Kathleen C. , Painter Corrie A. , Persky Nicole S. , Corbo Marco , Kirilenko Bodgan , Hiller Michael , Koepfli Klaus-Peter , Kaplow Irene , Wirthlin Morgan , Pfenning Andreas R. , Zhao Huabin , Genereux Diane P. , Swofford Ross , Lind Abigail , Pollard Katherine S. , Ryderq Oliver A. , Nweeia Martin T. , Meadows Jennifer , Dong Michael , Wallerman Ola , Marinescu Vikki , Lindblad-Toh Kerstin , Ray David A. , Power Sarahjane , Teeling Emma C. , Chauhan Gaurav , Li Shirley Xue , Karlsson Elinor K. , Lewin Harris A. 
Published: October 2020

How lethal coronaviruses engage hosts

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is closely related to the deadly coronaviruses SARS-CoV-1 and Middle East respiratory syndrome coronavirus (MERS-CoV). Considerable efforts are focused on developing treatments, and therapies that work across coronaviruses would be particularly valuable. Shedding light on the host factors hijacked by the viruses, Gordon
et al.
mapped the interactions between viral and human proteins for SARS-CoV-2, SARS-CoV-1, and MERS-CoV; analyzed the localization of viral proteins in human cells; and used genetic screening to identify host factors that either enhance or inhibit viral infection. For a subset of the interactions essential for the virus life cycle, the authors determined the cryo–electron microscopy structures and mined patient data to understand how targeting host factors may be relevant to clinical outcomes.

Science
, this issue p.
eabe9403