bluuebunny/crossref_metadata_2025 huggingface dataset:
Responses of Earthworms to Acetamiprid
Authors: Erhunmwunse Nosakhare Osazee , Tongo Isioma , Endurance Ewere E , Ogbeide Ozekeke . S. , Oruma Benedicta , Omniabios Christopher , Ikeh Rupert
Published: July 2023

To increase agricultural output, millions of tonnes of neonicotinoids are reportedly used worldwide, but these agrochemicals have negative impacts on soil quality and biodiversity. 98% of pesticides applied reach non-target organisms in the water and soil including the earthworms. Earthworm provides significant contributions to soil fertility and serves as a bioindicator for pesticide-induced soil pollution in an ecotoxicological investigation. In this study, earthworms (Aporrectodea longa) were subjected to commercial-grade Acetaminprid at various doses for 14 days and the LC50 was found to be 2.52 mg/kg. Morphological alterations and behavioral changes such as weight loss, avoidance, and growth rate were observed to be concentration-dependent. Catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPx), C-reactive protein (CRP), and Total Oxidative Capacity (TAC) activities were also measured. Significant alterations in these stress markers were detected in pesticide-exposed earthworms at increasing pesticide concentrations. Our findings showed that the exposed earthworm's growth rate decreased, its digging activity slowed down, it died, and it lost a significant amount of weight. These findings varied significantly depending on the pesticide concentration. This study indicates that Earthworms are particularly susceptible to acetamiprid, which cause immobility and rigidity, as well as a reduction of biomass and growth by disturbing numerous physiological activities, resulting in a loss of the earthworm population.
MiR-2110 induced by chemically synthesized cinobufagin functions as a tumor-metastatic suppressor via targeting FGFR1 to reduce PTEN ubiquitination degradation in nasopharyngeal carcinoma
Authors: Fang Shiyi , Hou Rentao , Zhang Mengmin , Deng Xing , Li Xiaoning , Xin Jianyang , Peng Lingrong , Liu Zhihua , Liu Yiyi , Xie Yingying , Fang Weiyi , Cheng Chao , Liu Zhen
Published: July 2023

Tumor cell metastasis is the key cause of death in patients with nasopharyngeal carcinoma(NPC). MiR-2110 was cloned and identified in Epstein-Barr virus (EBV)-positive NPC, but its role is unclear in NPC. In this study, we investigated the effect of miR-2110 on NPC metastasis and its related molecular basis. In addition, we also explored whether miR-2110 can be regulated by Cinobufotalin(CB) and participate in the inhibition of CB on NPC metastasis. Bioinformatics, RT-PCR, and In situ hybridization were used to observe the expression of miR-2110 in NPC tissues and cells. Scratch, boyden and tail vein metastasis model of nude mouse were used to detect the effect of miR-2110 on NPC metastasis. Western blot, CoIP, luciferase activity, co-localization of micro confocal and ubiquitination assays were used to identify the molecular mechanism of miR-2110 affecting NPC metastasis. Finally, miR-2110 induced by CB participates in CB-stimulated inhibition of NPC metastasis was explored. Increased miR-2110 significantly suppressed NPC cell migration, invasion, and metastasis. Suppressing miR-2110 markedly restored NPC cell migration and invasion. Mechanistically, miR-2110 directly targeted FGFR1 and reduced its protein expression. Decreased FGFR1 attenuated its recruitment of NEDD4, which downregulated NEDD4-induced PTEN ubiquitination degradation and increased PTEN protein stability, thereby inactivating PI3K/AKT-stimulated EMT signaling and ultimately suppressing NPC metastasis. Interestingly, cinobufagin (CB), a potential new inhibitory drug for NPC metastasis, significantly induced miR-2110 expression by suppressing PI3K/AKT/c-Jun-mediated transcription inhibition. Suppression of miR-2110 significantly restored cell migration and invasion in CB-treated NPC cells. Finally, a clinical sample assay indicated that reduced miR-2110 was negatively correlated with NPC lymph node metastasis and positively related to NPC patient survival. In summary, miR-2110 is a metastatic suppressor that is involved in CB-induced suppression of NPC metastasis.
Online Caching Algorithm for VR Video Streaming in Mobile Edge Caching System
Authors: Liu Qiuming , Chen Hao , Li Zihui , Bai Yaxin , Wu Dong , Zhou Yang
Published: July 2023

The transmission optimization of VR video streaming can improve the quality of user experience, which includes content prediction optimization and caching strategy optimization. Existing work either focuses on content prediction or on caching strategy. However, in the end-edge-cloud system, prediction and caching should be considered together. In this paper, we jointly optimize the four stages of prediction, caching, computing and transmission in mobile edge caching system, aimed to maximize the user's quality of experience. In terms of caching strategy, we design a caching algorithm VIE with unknown future request content, which can efficiently improve the content hit rate, as well as the durations for prediction, computing and transmission. The VIE caching algorithm is proved to be ahead of other algorithms in terms of delay. We optimize the four stages under arbitrary resource allocation and simulate the proposed caching algorithm according to the degree of overlap, as well as completion rate. Finally, under the real scenario, the proposed caching algorithm is verified by comparing with several other caching algorithms, simulation results show that the user's QoE is improved under the proposed caching algorithm.
Division mechanism of labor in Diqing Tibetan Pigs gut microbiota for dietary fiber efficiently utilization
Authors: Yang Lijie , Yao Bingqian , Zhang Shimin , Yang Yuting , Wang Gang , Zhou Junyan , Ye Changchuan , Pan Hongbin , Zeng Xiangfang , Qiao Shiyan
Published: July 2023

Background
The Diqing Tibetan (DT) pig is an herbivorous breed that inhabits an area with the highest altitude distribution in the world and can be maintained on a diet containing 90% forage material in confinement production systems. The possible association between specialized gut microorganisms and the efficient utilization of dietary fiber in this breed are unclear.
Results
Digestibility analysis showed that DT pigs had a strong capability for high-efficiency utilization of arabinose and xylose. Microorganisms in the cecum preferred to use xylan and uronic acid, while colonic microorganisms were better at using cellulose, glucan and mannan. Metagenomic analysis revealed that the high expression of feruloyl esterase, endo-β-1,4-xylanase, β-1,3-D-glucosidase, β-mannosidase, β-1,3(4)-glucanase and reducing-end xylanase in the intestinal microorganisms of these pigs was a decisive factor for the efficient utilization of nonstarch polysaccharides. The secretion of carbohydrate esterases was mainly undertaken by fecal strains of Microbacterium, Alistipes, Acinetobacter, and Faecalibacterium, while Microbacterium, Prevotella, Turicibacter, Lactobacillus, Clostridium and Streptococcus were responsible for most of the secretion of glycoside hydrolases. Then, a new species of Microbacterium was captured and appeared to have the highest fiber utilization ability in vitro, degrading 36.54% of the neutral detergent fiber in corn stover. The results of whole genome sequencing showed that the 16S rRNA sequence similarity between the strain and the microorganisms in the database was less than 97.113%, and the average nucleotide identity (ANI) was less than 95%. The strain was finally determined to be a brand new species, which was named Microbacterium sp. Qiao 01. Then, a total of 161 carbohydrate enzyme genes were annotated, including 80 glycoside hydrolases, 40 glycosyltransferases, 26 carbohydrate esterases, 11 auxiliary oxidoreductase, 3 polysaccharide lyases and 1 carbohydrate domain.
Conclusions
Our results provide strong evidence that efficient utilization of dietary fiber by DT pigs is due to the emergence of highly specialized microbial strategies in the gut. Microorganisms showed preferences and a clear division of labor in the degradation process of dietary fiber. Microbacterium sp. Qiao 01 was the key player in the efficient utilization of nonstarch polysaccharides in DT pigs. This study may inspire novel approaches for the deep excavation of high-quality microbial resources in regional species and has great practical significance for improving the utilization efficiency of livestock feed and alleviating the tension of food insecurity.
Adjuvant Lenvatinib in Combination with Transarterial Chemoembolization for Hepatocellular Carcinoma Patients with High-Risk of Postoperative Recurrence: A Prospective Cohort Study
Authors: Chen Jinhong , Lu Lu , Zhang Xiaoyun , Xiang Bangde , Xu Xiao , Li Xiangcheng , Huang Zhiyong , Wen Tianfu , Luo Liuping , Huang Jing , Zhong Jian-Hong , Liu Zhikun , Li Changxian , Long Xin , Zhu Wenwei , Yang Xin , Wang Chaoqun , Jia Huliang , Zhang Jubo , Zeng Yongyi , Lu Caide , Qin Lun-Xiu
Published: July 2023

Background
The high probability of tumor recurrence after curative surgery hinders the survival of patients with hepatocellular carcinoma (HCC). This prospective cohort study aimed to evaluate the efficacy and safety of lenvatinib (LEN) plus transarterial chemoembolization (TACE) as an adjuvant therapy in pre-defined HCC patients with high-risk of postoperative recurrence.
Methods
Patients who met the eligible criteria were enrolled between November 2018 to May 2021 from 8 hepatobiliary centers in China. The primary endpoint was disease-free survival (DFS). The secondary endpoints were overall survival (OS) and safety. Additionally, propensity score matching (PSM) and other propensity score analyses were performed to balance the potential confounding factors between groups to validate the conclusion. The treatment-related adverse events (AEs) were recorded throughout the entire study period.
Results
A total of 297 patients were enrolled, with 147 patients in the LEN + TACE group and 150 patients in the TACE group. Before PSM, patients in the LEN + TACE group achieved significantly better DFS than those in the TACE group (19.0 vs. 10.0 months, P = 0.011). PSM analysis identified 111 matched pairs of patients. LEN + TACEgroup also showed longer DFS in than the TACE group after PSM (19.0 vs. 9.0 months, P = 0.018). Further other three propensity score analyses yielded similar DFS benefit tendency after the potential confounding factors were adjusted in two groups. Although the median OS had not been reached in either of the two groups, both primary cohort and PSM cohort showed favorable OS benefit tendency in the LEN + TACE group. Intrahepatic recurrence was the most common recurrent location in both groups. Lenvatinib treatment-related AEs of grade 3 or 4 occurred in 28.6% of the patients in LEN + TACE group.
Conclusions
This study suggested that adjuvantlenvatinib plus TACE might be a promising approach for HCC patients with high-risk of postoperative recurrence, which could significantly reduce postoperative recurrence and prolong survival with a manageable safety profile.
Trial Registration ClinicalTrials.gov Identifier: NCT03838796.
Alternative meats and alternative facts
Authors: Van Eenennaam Alison L.
Published: July 2023

The alternative animal product arena is complex and quite var­ied. Some plant-based alternative meat products are derived entirely from plants. Other entrepreneurs are using cultivated cells of animal origin to derive a product structurally similar to meat and milk and comprised of animal proteins. Many of these endeavors use a combination of both approaches with the plant-based product providing filler for the cultivated meat or milk product. Most of the discussion around alternative meats has focused on bovine alternatives because of the iconic position of cattle in many climate and sustainability discussions. A consid­erable amount of capital has been raised based on the

envisioned market share of these products, although estimates vary widely, and the high profile initial public offering of Beyond Meat shares in May 2019 which saw share prices soar from $75 to $235, has this year seen share prices plummet to about one-tenth of that highest price. Proponents of alternative meats suggest these production systems are more sustainable based on antici­patory greenhouse gas emission (GHG) and land use life-cycle assessment (LCA)/kilogram (kg) of product, as compared to LCA metrics for ruminant meat. Much of the rationale

invokes a simplistic narrative around GHG/kg of protein. The GHG “sustainability” metric will invariably reflect poorly on ruminants as they are uniquely able to digest cellulose through their rumen microbes, and the methanogens produces methane which is a potent but short-lived greenhouse gas. And because ruminants are typically grazing in marginal land unsuitable for producing crops, they also have a high land use m2/kg of protein. However, there is no reason to conclude that food production on well-managed pasture and rangeland is, a priori, less sustainable than food production of well-managed arable cropland. More­over, the other sustainability externalities of ruminant meat production systems such as the provision of ecosystem services and biodiversity conservation, the consumption of inedible food waste and cellulose, manure, transportation, contributions to the livelihoods and food security of 1.3 billion livestock keepers, the fact that meat provides nutrients in addition to protein, and that existing harvesting systems utilize everything but the “moo” are often ignored or simply disregarded.
Comparing colostral bovine rotavirus and bovine coronavirus antibodies in primiparous and multiparous cows vaccinated pre-partum with two different multivalent vaccines
Authors: Prentice D. L. , Dhuyvetter K. C. , Jardon P. W.
Published: July 2023

Neonatal calf diarrhea (NCD) is a prevalent problem globally and in the U.S., data from NAHMS indicates that 50% of pre-weaned dairy heifer deaths are due to NCD. Bovine rotavirus (BoRV) and coronavirus (BoCV) are common viral causes of NCD. Dry cows are frequently vaccinated against these pathogens to enhance colostral antibody content. Studies have shown that vaccinating cows increases colostral antibodies but few published studies exist comparing different vaccines in this regard. The objective of this trial was to compare colostral antibody titers from cows given one of 2 commonly used multivalent vaccines compared to cows that were left as unvaccinated controls.
Effect of apple cider vinegar on the urine pH of lambs
Authors: Gibbons P. , Roberson J. , Smith S. , Larson R. , Wisniekski L.
Published: July 2023

Urolithiasis is a common disease in growing lambs. Acidifica­tion of the urine is both a treatment and prevention for struvite urolithiasis. Ammonium chloride has been shown to produce acidic urine within 24-72 hours, depending on dose. The chal­lenges with increasing ammonium chloride level in feed is the unpalatability of the salt and daily individual dosing has issues with client compliance. Apple cider vinegar has been used by producers as both a treatment and prevention of urolithiasis by both addition to water and by direct drenching. There is cur­rently a lack of evidence to support use of apple cider vinegar in the peer-reviewed literature. The objectives of this study were to investigate the effect of apple cider vinegar on the urine pH of sheep when drenched by mouth and compare the effects on urine pH to ammonium chloride.
University Student Satisfaction and Behavioural Engagement During Emergency Remote Teaching
Authors: Taşkın Necati , Kandemir Bülent , Erzurumlu Kerem
Published: July 2023

This study aimed to examine students' online satisfaction in the context of emergency remote teaching. The research was carried out in a concurrent triangulation design from the mixed method. The quantitative data of the study were collected from 2663 students studying at different faculties/schools of a state university in Turkey in the fall semester of the 2020-2021 academic year. Participants consist of students who participated voluntarily according to the convenient sampling method. Qualitative data were collected from 494 students who express their opinion through free text answers. The "e-satisfaction scale" was used to determine students' online learning satisfaction. The number of logins to live course, the number of recorded course view and the number of logins to LMS of students are behavioural engagement indicators. According to the findings, the students have a moderate level of satisfaction. There is a significant difference between both academic achievement and engagement of students with different satisfaction levels. Longing for face-to-face education, the usefulness of the LMS, inadequate assessment, the inefficiency of online learning, technical problems, challenges of the process, and insufficient instructors are opinions frequently mentioned by students. The results obtained in this study not only determine the current situation regarding student satisfaction but also provide important clues about improving online learning.
Emergency Remote Teaching: The Challenges Associated with a Context of Second Language Instruction
Authors: MacKinnon Gregory , MacLean Tyler
Published: July 2023

The pandemic of 2020 frequently necessitated that offshore school teachers continue their instruction of Chinese children in the online format rather than face-to-face back in China; a so-called emergency remote teaching response. A required change in pedagogy accompanied a range of challenges in an effort to offer quality education to English as a Second Language (ESL) students. During the fall 2020-2021 academic year, a sample of 25 teachers and 3 principals provided feedback on those inherent challenges in a mixed method study consisting of surveys, interviews, and focus groups. Factors that impacted the delivery were identified in broad categories of teacher lifestyle, hindrances with technology, teaching practice, and pedagogical support. The findings were unique in that 1) they were nested in a response to a difficult context as opposed to a carefully planned online instruction and 2) second language students constituted a different learning cohort. This work further adds to the literature by suggesting that cognitive load, self-regulation, and attentional literacy deserve careful consideration when contexts of ESL learning with technology are implicated.
This work further adds to the literature by suggesting that cognitive load, self-regulation and attentional literacy deserve careful consideration when contexts of ESL learning with technology are implicated.
Editorial Volume 49 Issue 1
Authors: Dabrowski Michael , Cleveland-Innes Martha
Published: July 2023

The spectre of COVID-19 and its global transformational legacy on all aspects of teaching and learning overshadows this issue of the Canadian Journal of Learning and Technology. The near-universal demand for remote learning and the reliance on learning technologies not only transformed the educational environment but also shifted many preconceived notions about the interplay between the dissemination of knowledge and technology. The surge in technology's prominence in education and the quick pedagogical pivot impacted all aspects of teaching and learning with both short- and long-term consequences. This issue explores the impact of this shift, the slow recovery and the permanent transformation of the learning landscape from the institutional, teacher, and student perspectives. We invite you to review the content summary of this journal issue.
Effects of applications of synthetic polymer and humic acid on resistance to dispersion and mechanical forces
Authors: ÖZDEMİR Nutullah
Published: July 2023

In this study, the effects of the addition of polyvinyl alcohol (PVA), polyacrylamide (PAM), and humic acid (HA) to soils in sandy loam, loam, and clay texture classes on their resistance to dispersion and mechanical forces were examined. The study was performed under greenhouse conditions using surface soil samples and 1.5 kg pots. Furthermore, the study was planned as an incubation experiment and the application of PVA, PAM, and HA at 500, 100, and 500 ppm doses for each soil texture class, respectively. During the incubation times (1 (0), 2 (15), 3 (30) 30, and 4 (45) days), the irrigation process was repeated as half of the available moisture in the soil was depleted. Ultimately, the applications of PVA, PAM, and HA on soils in sandy loam, loam, and clay textures increased the liquid limit/ pF'2 moisture ratio (LL/pF'2) values in them by 6.30%, 5.99%, and 7.30%, respectively, (reducing the tendency to dispersion) compared to the control. Furthermore, the applications increased the plastic limit/pF’2 moisture ratio (PL/pF’2) values (resistance to mechanical forces) by 22.31%, 16.50%, and 9.27%, respectively. Incubation time 1 was more effective in reducing dispersion and increasing resistance to mechanical forces, and the effects decreased over time. PVA was the most effective conditioner for all three soil groups.
Extracto acuoso de Eucalyptus globulus Labill. en la germinación y desarrollo de cultivos andinos: un estudio de alelopatía en Cusco, Perú
Authors: Gil-Mora Juan Eduardo , Casas-Toribio Stephanie M.
Published: July 2023

La alelopatía se define como el efecto perjudicial que una planta ocasiona a otra a través de compuestos químicos que son liberados al medio; en Perú la especie más utilizada en plantaciones es el Eucalyptus globulus Labill.; a pesar de la reconocida utilidad para diversos usos en la zona andina; durante las últimas décadas existen críticas basadas en argumentos científicos, ecológicos y emocionales, que sostienen que el eucalipto deteriora el suelo y fuentes de agua; considerando estas aseveraciones se evaluó la alelopatía mediante bioensayos con extracto acuoso de eucalipto provenientes de plantaciones en cuatro provincias del Cusco: Anta, Calca, Cusco y Quispicanchis; mediante ensayos de alelopatía efectuados con extracto acuoso de hojas, ramas tiernas y frutos de eucalipto en la germinación y crecimiento de las plántulas de Amaranthus caudatus L. (kiwicha), Chenopodium quinoa Willd. (quínua), Hordeum vulgare L. (cebada), Vicia faba L. (haba) y Zea mays Vell. (maíz) y llevados a cabo a concentraciones de 10; 25; 50; 100 y, 1,000 mg/L y para el ensayo testigo se utilizó agua destilada; para el análisis de la información obtenida sobre alelopatía, se utilizó el software TREND, utilizando tres métodos de tendencia: T de Student, prueba de Spearman y la regresión lineal. Las concentraciones a las que se sometieron las cinco especies de cultivos andinos no inhibieron la germinación de las semillas, ni el desarrollo de las plántulas, tampoco afectaron la longitud y peso respecto del testigo; por lo tanto, se colige que, el extracto acuoso del eucalipto no inhibe el desarrollo de las monocotiledóneas (maíz y cebada), tampoco a las dicotiledóneas (haba, quinua y kiwicha). Consecuentemente, los efectos alelopáticos que genera el eucalipto en cultivos de haba, maíz, cebada, quinua y, kiwicha son nulos en los bioensayos a diferentes concentraciones con extracto acuoso, no ocasionando efectos alelopáticos que puedan inhibir la germinación de las semillas ni el crecimiento de las plántulas, por lo que se concluye que el Eucalyptus globulus no produce alelopatía. En Perú y Cusco se ha utilizado E. globulus para reforestación y por ello es importante conocer el impacto ecológico que sus aleloquímicos tienen sobre el suelo puesto que pueden afectar a la flora y fauna nativas.
Bioactive Compounds from Penicillium sp. Inhibit Antiapoptotic Bcl-2, Bcl-XL and Mcl-1: An in silico Study
Authors: Massardi Adhie , Bahry Sandy Samsul , Rahmawati Nur Anindya , Shabirah Carissa Azmi , Pangastuti Artini
Published: July 2023

Background: Antiapoptotic Bcl-2 proteins are overexpressed in cancer cells, leading to inhibition of apoptosis and the development of therapeutic resistance. Targeting only one type of antiapoptotic protein may have limited efficacy in cancer therapy. Anticancer drugs capable of inhibiting Bcl-2, Bcl-XL and Mcl-1 simultaneously are necessary to be explored. Penicillium sp. produces various bioactive compounds with anticancer, antibacterial, and antiviral activities. The aim of this research was to determine the best bioactive compound candidates for inhibiting Bcl-2, Bcl-XL, and Mcl-1 proteins.Materials and methods: Molecular docking analysis was conducted to estimate the binding affinity of Penicillium sp. bioactive compounds with Bcl-2, Bcl-XL, and Mcl-1 proteins. Compounds with the lowest binding energies were visualized using PyMol and Ligplot+ and further subjected to drug-likeness testing based on Lipinski's rule of five.Results: Bioactive compounds with the highest binding affinities were verruculogen and wortmannin. Wortmannin complied with Lipinski's rule of five. Meanwhile, verruculogen violated one out of the five rules by having a molecular weight >500 Da. Both compounds could be used as oral drugs.Conclusion: Verruculogen and wortmannin from Penicillium sp. show significant potential as oral anticancer drug candidates.Keywords: Bcl-2, Bcl-XL, Mcl-1, Penicillium sp., in silico
FAKTOR-FAKTOR YANG MEMPENGARUHI KETEPATAN WAKTU PENYAMPAIAN LAPORAN KEUANGAN (STUDI EMPIRIS PADA PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BEI PERIODE 2018-2020)
Authors: Sari Novita , Gowon Muhammad , Yustien Reni
Published: July 2023

Penelitian ini bertujuan untuk menemukan  bukti empiris tentang pengaruh dari Profitabilitas, Debt Equity ratio, Likuiditas, Umur Perusahaan, Kualitas Auditor, Opini Audit, dan Ukuran Perusahaan terhadap ketepatan waktu penyampaian laporan keuangan pada perusahaan manufaktur yang terdaftar di bursa efek Indonesia (BEI)  untuk periode 2018sampai 2020.Jenis penelitian yang digunakan adalah penelitian kuantitatif dengan menggunakan data skunder. Berdasarkan metode pengambilan sampel dengan menggunakan purposive sampling , maka didapat sampel sebanyak 30 perusahaan, sehingga jumlah sampel perusahaan dari tahun 2018 sampai 2020 adalah sebanyak 90 sampel. Data yang digunakan dalam penelitian ini adalah data dari laporan keuangan perusahaan manufaktur yang dipublikasikan di website resmi www.idx.co.id tahun 2018-2020. Pengujian hipotesis menggunakan analisis regresi linear berganda.
Hasil penelitian ini menunjukkan bahwa Profitabilitas, Umur Perusahaan, Kualitas Auditor, Opini audit, dan Ukuran Perusahaan berpengaruh Signifikan terhadap ketepatan waktu penyampaian laporan keuangan, sedangkan Debt Equity Ratio, dan Likuiditas tidak berpengaruh terhadap ketepatan waktu penyampaian laporan keuangan. Variabel independen dapat menjelaskan pengaruh ketepatan waktu penyampaian laporan keuangan sebesar 41,10% sedangkan sisanya 58.9% dipengaruhi oleh faktor lain yang tidak dimasukkan dalam model regresi ini.
THE INFLUENCE OF TRAINING ROLES, SELF-EFFICACY, CREATIVE PROBLEM-SOLVING ON IMPROVING EMPLOYEE PERFORMANCE
Authors: Layyinah Afifah Gusti , Subiyanto Didik
Published: July 2023

Employee performance is an essential component of comparing a company with its employees to achieve productive and efficient results. It can be found in any organization, especially in the Bantul Trade Service. This quantitative study aims to find information about training, self-efficacy, creative problem solving on the performance of employees in the Bantul Trade Service. At the same time, 57 employees were involved in the study, with 34 state civil apparatus and 30 contract employees. The research procedure used is a sample saturated with the amount available. The information collected by the questionnaire is then processed and evaluated using SPSS 24, a descriptive statistical system. The findings of this study showed that the training did not have a positive or significant impact on the performance of employees at the Bantul trade service. The absence of training offered by the Department to each employee affects this issue. Self-efficacy and creative problem solving, on the other hand, have a beneficial and considerable impact on employee performance. To improve employee performance at the Bantul Trade Office, training, self-efficacy, and creative problem solving must be maximized through suitable training and education for staff.
THE ROLE OF ONLINE CUSTOMER REVIEWS IN INCREASING IMPULSIVE PURCHASE OF FASHION PRODUCTS ONLINE WITH CUSTOMER TRUST AS A MEDIATOR
Authors: Hilal Anisaul Karimah , Septin Puji Astuti
Published: July 2023

This study purposes to analyze online consumer reviews on impulsive purchases, and with customer trust as a mediating variable. This research was conducted in 2022. The population was consumers who have experiences in shopping online through social media or other online shopping applications in Indonesia. The sample of this research was 400 respondents. Data analysis techniques used the Structural Equation Model (SEM). The data were primary data. Data collection applied a questionnaire. The results of the research conclude three findings: First, online consumer reviews have a significant effect on trust. This means that the more consumers read online consumer reviews, the higher the consumer's trust in the product and the online seller. Second, trust has a significant effect on impulsive buying decisions meaning that the higher the level of consumer confidence in a product, the higher the probability that consumers will buy the product. Third, online consumer reviews have a significant effect on impulsive purchases with trust as a mediator. This indicates that the more consumers read online consumer reviews, the higher the possibility of impulsive purchases, supported by the existence of trust which greatly influences the variables between the two, between online consumer reviews on trust and trust on impulsive purchases.
Pulmonary fibrosis: risk factors, pathogenesis and in vivo/in vitro experimental modeling
Authors: Chistyakova Irena V. , Malashicheva Anna  B.
Published: July 2023

Pulmonary fibrosis (PF) is a group of lung diseases characterized by scar formation and interstitial pneumonia with a mean life expectancy of 35 yearspost diagnosis. Risk factors for developing PF include external (environment) and internal (genetic risk factors). The central role in the formation of fibrosis is played by the massive myofibroblasts and the excessive deposition of extracellular matrix, including collagen I type.
The main approaches for PF treatment is either lung transplantation or therapeutic treatment by antifibrotic drugs. However, for both approaches there are a number of limitations: for surgical the lack of donor organs and immune rejection of transplanted tissues, for therapeutic the drugs that are identified in animal studies fail in human clinical trials. Thus, there is a necessity for advancing of humanized in vitro models to improve treatments prior to human clinical trials.
The development of different tissue (two-, three-dimensional) models has created systems capable of emulating human lung structure, function, and cell and matrix interactions, which have shown potential for in vitro drug testing. In this review, we focused on PF risk factors, development mechanisms, and a review of the main in vitro and in vivo models for studying PF.
The Role Of Guidance and Counseling Information Services Through Interprofessional Education
Authors: Bebasari Mardiani , Gistituati Nurhizrah , Biran Mega Iswari , Solfema  , Hadiyanto
Published: July 2023

This article was created to find out how to describe the role of guidance and counseling information services through interprofessional education. The aim of IPE is the practice of inter-professional collaboration, which involves various professions in learning about how to work together by providing the knowledge, skills and attitudes needed to collaborate effectively. This research method uses library research to examine through writings from books regarding cooperative learning models in interprofessional education. Information services are guidance and counseling services that enable students to receive and understand various information that can be used as material for consideration and decision-making for the benefit of students. Information services are services that provide information needed by individuals. Guidance and counseling services have very important functions and roles in schools, especially for students. By providing BK services the development of students will be more optimal. Counseling guidance services focus on developing personal and social aspects as well as solving problems individually. With these services it is hoped that students will be in prime condition, so that they can learn and develop themselves personally. According to WHO Interprofessional education or IPE is an educational process that involves two or more types of professions. Interprofessional education can occur when several students from various professions learn about other professions, learn together with one another to create effective collaborations.
The Impact of Self-efficacy Towards Speaking Performance
Authors: I Gde Putu Agus Pramerta
Published: July 2023

This present study is an associational study that employed simple linear regression model. There were two variables in this study such as self-efficacy as the independent variable while speaking performance as the dependent one. This study was conducted at a public university in Indonesia. The subjects recruited were 75 students. The data were collected by administering a self-efficacy questionnaire which contains 28 items. The data were analyzed quantitatively using SPSS program. The results show that mostly, the students had average and high category of SE as shown by 22.7% and 38.7% respectively. Moreover, it was found that F (1, 72) = 17.950, p < 0.001. It means that statistically there was an impact of students’ self-efficacy toward students’ speaking performance. Based on the aforementioned results, it can be concluded that the students had good potential to enhance their speaking skills and their SE had significant contribution to their speaking performance.
Determinantes na decisão de aposentadoria do servidor público
Authors: Oliveira Paula Karlleyne Queiroz , Almeida Alexandre Nascimento de
Published: July 2023

O entendimento da decisão de aposentadoria é indispensável para a gestão etária das organizações. O objetivo do estudo foi analisar os motivos que levam servidores públicos a aposentarem ou adiarem esse direito. Os dados foram obtidos pela aplicação de questionário aos servidores de uma autarquia pública, sendo analisados por meio de estatística descritiva e análise de conteúdo. Os resultados indicaram que a decisão de aposentar é influenciada por fatores individuais e organizacionais. A decisão de adiar a aposentadoria foi influenciada por motivos financeiros e por aspectos relacionados ao bom ambiente de trabalho. A maioria dos servidores que pretendem aposentar imediatamente foram os que perceberam a aposentadoria como uma oportunidade para aproveitarem a vida ou para ingressarem em outra carreira profissional.
Itinerários de produção científica: pesquisas LGBTQI+ no marketing
Authors: Tressoldi Cassiano
Published: July 2023

Os indivíduos LGBTQI+ compõe um grupo de consumidores que vem atraindo atenção de profissionais de marketing, principalmente pelo seu potencial de consumo. Assim, esse artigo tem o propósito de mapear os estudos em marketing que tem como objeto de pesquisa o consumidor LGBTQI+, no período que compreende os anos de 2009 a 2019, na plataforma Web of Science. Para tanto, 31 publicações foram encontradas para análise final. Como resultados, foi possível constatar a existência de cinco linhas principais de pesquisa. A partir dessas linhas, identificou-se as lacunas existentes e sugeriu-se pesquisas futuras.
Opt-Out: por que profissionais da Geração Z optam por deixar as empresas?
Authors: Leite Kaleandra , Hahn Ivanete Schneider , Scherer Flavia Luciane , Trindade Nathália Rigui
Published: July 2023

O movimento opt-out trata do fenômeno que ocorre quando os profissionais “optam por sair” das empresas. A presente pesquisa se propõe a investigar as motivações das pessoas da Geração Z para realizarem o movimento de opt-out. Para tal, foi conduzida uma pesquisa descritiva, de natureza qualitativa, por meio de entrevistas em profundidade com seis pessoas da Geração Z que “optaram por sair”. Para análise dos dados utilizou-se o método de análise de conteúdo. Os resultados apontam que a falta de autonomia, falta de equilíbrio entre a vida profissional e pessoal, falta de reconhecimento, não pertencimento ao local de trabalho, não conseguir ser livre esteticamente e a falta de possibilidade de poder criar e inovar foram os motivadores do movimento opt-out.
O público LGBTQ+ e a compra de produtos locais
Authors: Lira Jordana Soares de , Silva Júnior Omero Galdino da , Sousa Júnior João Henriques de
Published: July 2023

O objetivo desse estudo consistiu em identificar os fatores que influenciam no comportamento de compra de marcas locais pelo consumidor homoafetivo. Essa pesquisa tem caráter quantitativo descritivo e utilizou uma amostragem do tipo não-probabilística. A coleta de dados realizou-se por meio de um survey online. Os dados foram analisados por meio de um software estatístico viabilizando análises descritivas e a relação entre as variáveis. Os resultados apontam que, embora os consumidores homoafetivos tenham um comportamento de consumo voltado para marcas globais, há a intenção de consumir uma marca local devido a uma postura de consumo socialmente responsável, por meio do qual aspectos sociais se tornam mais relevantes e decisivos, no momento da compra.
Legitimidade organizacional: uma conceitualização para a Ouvidoria Pública
Authors: Biagini Liane , De Oliveira Leite Regina Maria , Ferraz Esteves de Araújo Joaquim Filipe , Coutinho Paschoal Dourado Débora
Published: July 2023

A ouvidoria pública desempenha um papel importante por contribuir com a melhoria dos serviços. Ao aproximar o usuário da organização, ela favorece aspectos democráticos, como, o controle social. Mas barreiras podem ser impostas às suas atividades, tornando necessário que ela se muna de legitimidade e se fortaleça para cumprir seu papel. Através da pesquisa qualitativa e análise de conteúdo, buscou-se analisar como a conceptualização da legitimidade pragmática, definida por Suchman, se configura na perspectiva da ouvidoria pública. Os resultados demonstram que as ouvidorias investigadas transitam entre a imagem de desconfiança e incredulidade para uma imagem de confiabilidade e credibilidade. Assim elas precisam rever seus conceitos, atuações e as práticas organizacionais para que se tornem institutos imbuídos de um papel democrático.
Coğrafi Bilgi Sistemleri ve Analitik Hiyerarşi Prosesi ile Kestane (Castanea sativa Mill.) Ağaçlandırmaları İçin Uygun Alanların Tespiti
Authors: AKSOY Hasan
Published: July 2023

Arazi kullanımının doğru ve verimli bir şekilde uygulanabilirliği için yer seçimi ve kullanım tipinin belirlenmesi çok önemlidir. En uygun yer seçimi, ülkemizde özellikle kırsal kesimlerde sosyal ve ekonomik yönden daha verimli bir kazanç elde edilmesini sağlayacaktır. Ülkemizde kırsal kalkınma için gelir getirici türlerin ağaçlandırma çalışmalarına yönelik teşvikler yapılmakta, dolayısıyla teşviklerden maksimum fayda ve kazanç sağlamak açısından amaca göre en uygun alanın belirlenmesi gerekmektedir. Bu çalışma, hem doğal yayılış gösteren hem de coğrafi işaret almış kestane ormanlarının bulunduğu Sinop Orman Bölge Müdürlüğü, Ayancık Orman İşletme Müdürlüğünde gerçekleştirildi. Çalışmada Coğrafi Bilgi Sistemleri (CBS) ve Analitik Hiyerarşi Prosesi (AHP) yöntemi kullanılarak uygun kestane (Castanea sativa Mill.) ağaçlandırma alanları belirlendi. AHP için bonitet, arazi kullanımı, yükseklik, eğim ve bakı olmak üzere toplam beş kriter kullanıldı. Bu kriterlere ilişkin uygunluk haritaları ağırlıklarına göre çakıştırılarak uygun kestane ağaçlandırma alanı haritası oluşturuldu. Sonuçlar kestane ağaçlandırması için çalışma alanının %0,42 (340,57 ha)’sinin çok uygun, %2,38 (1.906,25 ha)’inin uygun, %22,96 (18.410,75 ha)’sının orta uygun, %63,54 (50.952,75 ha)’ünün uygun olmayan ve %10,70 (8.584,00 ha)’inin ise hiç uygun olmayan alanlardan oluştuğu tespit edildi. Çalışma alanının %25,76 (22.904,39 ha)’lık kısmında yapılacak kestane ağaçlandırması için yüksek verim ve kazanç sağlanması beklenmektedir.
DEVELOPMENT OF INTEGRATED SCIENCE WORKSHEET BASED ON LEARNING CYCLE 5E ON ENERGY IN LIVING SYSTEMS MATERIALS
Authors: Dewi Intan Puspita , Diliarosta Skunda
Published: July 2023

Based on the analysis conducted, it is known that the problems faced in the learning process are that students are not actively involved in the learning process. This is because the methods and teaching materials used have not been able to facilitate students to be actively involved in the learning process. This study aims to produce an integrated science worksheet based on the learning cycle 5E on energy in living systems materials and determine the level of validity and practicality of its use. This type of research is Research and Development (R&D) with the ADDIE development model which is limited to the development stage. The research instrument is a validity and practicality questionnaire. The research data were analyzed using the moment kappa formula. The results of the development stage inform that the LKPD developed is declared valid with the validity value given by the three validators is 0.78 with a high validity category. The developed LKPD is also stated to be practical with the practicality value given by the teacher is 0.98 with a very high practicality category and the practicality value of the students is 0.84 with a very high practicality category.
The contribution of music to health promotion and the creation of a therapeutic environment in the community
Authors: Stathopoulou Andriana , Kavga Anna , Kampa Evridiki , Fasoi Georgia
Published: July 2023

Introduction: The value of art, and especially music, can potentially approach a person in a multifaceted way and make a significant contribution to maintaining his or her health by acquiring through this interaction a decisive role in promoting health.
Aim: The aim of this study was to investigate the use of music for community health screening and the degree of reinforcement of socio-emotional trust that it can build, contributing effectively to the work of the nurse.
Methodology: A quantitative study was carried out with a feasibility sampling of people visiting two different institutions in Attica and suffering from mild or severe mental disorder. The sample size was 120 (N = 120) with a response rate of 80%. An anonymous, structured, self-completed questionnaire was used to collect the data. The validity and reliability of the test was tested by a pilot study involving 20 subjects (N = 20).
Results: Music has emerged as an important health factor for the individual without even requiring specific knowledge as it is inherent in man. Its versatile and multi-dimensional character is confirmed, and it helps the individual to manage various difficulties and gain a positive attitude in life. Its potential seems to be
strengthened and its effectiveness enhanced through the team and the group experience.
Conclusions: The present study shows that music hides a unique power and with its proper utilization offers multiple benefits to the individual. The simplicity of its implementation enables it to be used effectively in community nursing interventions and in other areas of health care while promoting public health.
Novel targeted cancer therapy based on β-hydroxybutyric acid associated energy metabolism regulated by intestinal flora
Authors: Zhang Fenfen , Lv Yifei , Zhou Xiaolun , He Yangyang , Yang Jianshe
Published: July 2023

β-hydroxybutyric acid (β-HBA) is a water soluble small molecule and the main component of ketone body. Upon facing energy shortage, free fatty acids in liver are oxidized and decomposed in mitochondria to produce β-HBA. β-HBA is a carbon source providing energy for extrahepatic tissues such as brain, heart, and skeletal muscles. Intestinal flora is the key component of regulating the host lipid metabolism and other metabolic activities of human body. The imbalance of intestinal flora may lead to the disorders of fatty acid metabolism having impact on cardiovascular, nervous, metabolic systems, etc. This work discusses the potential regulatory mechanism of intestinal flora involved in producing β-HBA through metabolic pathway, molecular mechanism of β-HBA production, physiological effects in animals, and relation between intestinal flora and fatty acid metabolism. These outcomes can provide reference for further work on β-HBA production in treating diseases, especially for cancer treatment in terms of the energy metabolism.
Study on Secular Change of the Earth’s Rotation Rate Based on Solar Eclipse Observation Records on October 13, 443 BC
Authors: MA Lihua
Published: July 2023

An observation of a solar eclipse that occurred on October 13, 443 BC during the reign of the Duke Ligong of Qin was recorded in the Twenty-Four Histories (China’s dynastic histories from remote antiquity till the Ming Dynasty). With modern astronomical planetary ephemeris, the observation records were studied. The results showed that the eclipse probably occurred around sunset in Yongcheng, the capital of Qin, where the sunset time was exactly between the first contact stage (partial eclipse begins) and the fourth contact stage (partial eclipse ends) of the eclipse. Furthermore, secular change of the earth’s rotation rate at that time is investigated in this work.
Influence of glass dealkalization on the quality of adhesion of bonded materials
Authors: Kordová T. , Mareška A. , Míka M. Havlík
Published: July 2023

The aim of this paper is to determine the effect of dealkalization of the glass surface on the quality of adhesion of bonded parts to the glass. Most of the available studies on glass dealkalization tend to focus only on the properties of the glass itself and the processes taking place in the surface layers of the glass. However, in practice focused on adhesion, the cleanliness of the glass surface is an important factor, which is influenced, among other things, by dealkalization. In this work, the influence of the use of gaseous SO2in the furnace on the composition of the glass surface and on the resulting adhesion is assessed. Regarding the deterioration of the adhesion quality between the glass treated with SO2gas and the adhesion promoter, the cleaning efficiency of the glass surface was further tested, according to the results of the cross-cut test.
The use of an endovascular balloon to increase the safety of laparoscopic decompression of the abdominal trunk
Authors: Khamid Z. M. , Bazunov A. K. , Biryukov A. V. , Vasilevsky D. I. , Korolkov A. Yu. , Balandov S. G. , Puzanov S. Yu. , Rumyantsev I. P. , Bagnenko S. F.
Published: July 2023

The OBJECTIVE was to increase the safety of laparoscopic decompression of the abdominal trunk.

METHODS AND MATERIALS. The results of treatment of 30 patients who underwent laparoscopic decompression of the celiac trunk were analyzed. Intraoperative bleeding requiring conversion to laparotomy occurred in two (6.7%) cases.

RESULTS. To prevent such a complication, a method of preventive installation of a balloon catheter into the celiac trunk was introduced, which allows creating a temporary occlusion of the vessel in case of damage. A similar approach was used in 10 (33.3%) patients. The need to cover the lumen of the vessel with a balloon arose in one observation (3.3% of all patients and 10.0% using this technique). Bleeding from the inferior phrenic artery, which originated from the celiac trunk, was stopped by laparoscopic access.

CONCLUSION. The experience presented in this paper allows us to consider the installation of a balloon boat in the celiac trunk as one of the possible ways to improve the safety of its laparoscopic decompression. Further research is needed to obtain a definitive picture of the effectiveness of this approach.