bluuebunny/crossref_metadata_2025 huggingface dataset:
10-µJ few-cycle 12-µm source based on difference-frequency generation driven by a 1-kHz mid-wave infrared OPCPA
Authors: Duda Martin , von Grafenstein Lorenz , Bock Martin , Ueberschaer Dennis , Fuertjes Pia , Roškot Lukáš , Smrž Martin , Novák Ondřej , Griebner Uwe
Published: May 2022

We report on high-energy, few-cycle pulse generation in the long-wave infrared spectral region via difference-frequency generation (DFG) in GaSe and AgGaSe2 nonlinear crystals. The DFG is driven by the signal at 3.5 µm and idler at 5 µm of a high-power mid-wave infrared optical parametric chirped pulse amplification (OPCPA) system operating at a 1-kHz repetition rate. The DFG pulses contain up to 17 µJ of energy and cover a spectrum from 8.5 µm to 14.5 µm. They are generated with a conversion efficiency of 2.1 %. Compression results in 10.2-

μ

J pulses with sub-150-fs duration, corresponding to less than four optical cycles.
Second harmonic generation by quasi-phase matching in a lithium niobate thin film
Authors: Zhang Honghu , Li Qingyun , Zhu Houbin , Cai Lutong , Hu Hui
Published: May 2022

Lithium niobate thin film becomes a promising material platform for integrated nonlinear optics. Quasi-phase matching is an important way to realize optical frequency conversion. Due to the strong dispersion of the high-refractive-index-contrast lithium niobate thin film waveguides, a small poling period (several micrometers) is needed, which becomes a challenge for the poling process. In this paper, a periodic reversed domain with a period of 3.8 µm was realized by poling with an external electric field in the x-cut lithium niobate thin film. The reversed domains were characterized by piezoresponse force microscopy and the confocal Raman spectroscopy. The second harmonic generation was realized in the ridge waveguides, and the normalized conversion efficiency was 684%W−1cm−2. The waveguide loss, the irregularity of the reversed domain, and the inhomogeneities effective index along the waveguide were analyzed to be the main sources of the conversion efficiency decrease. The simulations showed that the phase matching was very sensitive to waveguide geometry. This work provided useful information for studying second harmonic generation in the lithium niobate on insulator.
Transition in social risk factors and adolescent motherhood in low- income and middle- income countries: Evidence from Demographic and Health Survey data, 1996–2018
Authors: Huda M. Mamun , Finlay Jocelyn E. , O’Flaherty Martin , Al Mamun Abdullah
Published: May 2022

Understanding the dynamics of social risk factors in the occurrence of adolescent motherhood is vital in designing more appropriate prevention initiatives in low-income and middle-income countries (LMICs). We aimed this study to examine the transition of social risk factors and their association with adolescent motherhood in LMICs since the initiation of the MDGs. We analysed 119967 adolescent girls (15–19 years) from 40-nationally representative Demographic Health Surveys in 20 LMICs that had at least two surveys: a survey in 1996-2003(baseline, near MDGs started) and another in 2014-2018(endline). Adolescent motherhood (having a live birth or being pregnant before age 20) was the outcome of interest, whereas social risk factors including household wealth, girls’ level of education, and area of residence were the exposures. The association between adolescent motherhood and the social risk factors, as well as changes in the strength of the association over time were observed using multilevel logistic regression analysis. On an average, the proportion of adolescent mothers without education decreased by -15·61% (95% CI: -16·84, -14·38), whereas the poorest adolescent mother increased by 5·87% (95% CI: 4·74, 7·00). The national prevalence of adolescent motherhood remained unchanged or increased in 55·00% (11/20) of the studied countries. Comparing baseline to endline, the overall adjusted odds ratio (AOR) of adolescent motherhood increased for both poorest (AOR = 1·42, 95% CI: 1·28, 1·59) and rural residences (AOR = 1·09, 95% CI: 1·01, 1·17), and decreased, but not statistically significant for the low level of education (AOR = 0·92, 95% CI: 0·84, 1·01 for no education). Our study concludes that social risk factors of the adolescent mother had shifted in different directions during MDGs and SDGs eras, and adolescent mothers remained more disadvantaged than non-mothers in LMICs. Efforts need to be enhanced to improve adolescent girls’ education. Intervention should be prioritised in disadvantaged communities to delay adolescent first birth and prevent adolescent motherhood in LMICs.
Phase II trial of nafamostat mesilate/gemcitabin/S-1 for unresectable pancreatic cancer
Authors: Uwagawa Tadashi , Sakamoto Taro , Gocho Takeshi , Shiba Hiroaki , Onda Shinji , Yasuda Jungo , Shirai Yoshihiro , Hamura Ryoga , Furukawa Kenei , Yanaga Katsuhiko , Ikegami Toru
Published: May 2022

Purpose

To assess the efficacy of combination chemotherapy with nafamostat mesilate, gemcitabine and S-1 for unresectable pancreatic cancer patients.

Materials and methods

The study was conducted as a single-arm, single center, institutional review board-approved phase II trial. Patients received nafamosntat mesilate (4.8 mg/kg continuous transregional arterial infusion) with gemcitabine (1000 mg/m2 transvenous) on days 1 and15, and with oral S-1 [(80 mg/day (BSA<1.25 m2), 100 mg/day (1.25 ≤ BSA<1.5 m2), or 120 mg/day (BSA ≥1.5 m2)] on days 1–14 or, days 1–7 and 15–21. This regimen was repeated at 28-day intervals.

Results

Forty-seven evaluable patients (Male/Female: 31/16, Age (median): 66 (range 35–78) yrs, Stage III/IV 10/37.) were candidates in this study. Two patients in stage III (20%) could undergo conversion surgery. Twenty-four patients (51%) underwent subsequent treatment (1st line/ 2nd line / 4th line, 13/ 10/ 1, FOLFIRINOX: 12, GEM/nab-PTX: 18, TAS-118: 3, chemoradiation with S-1: 2, GEM/Erlotinib: 1, nal-IRI: 1, surgery: 2). Median PFS and OS were 9.7 (95% CI, 8.9–14.7 mo) and 14.2 months (99% CI, 13.3–23.9 mo), respectively. Median PFS in stage IV patients was 9.2 months (95% CI, 8.4–12.0 mo). Median OS in patients without subsequent treatment was 10.8 months (95% CI, 9.1–13.8 mo). Median OS in patients with subsequent treatment was 19.3 months (95% CI, 18.9–31.9 mo). Grade 4 treatment-related hematological toxicities were encountered in 7 patients. Two patients developed grade 3 allergic reaction after 6 cycles or later. No febrile neutropenia has been observed.

Conclusion

NAM/GEM/S-1 therapy is safe and could be promising option for unresectable pancreatic cancer, especially for stage IV cancer.
COVID-19 vaccination in Nigeria: A rapid review of vaccine acceptance rate and the associated factors
Authors: Olu-Abiodun Oluwatosin , Abiodun Olumide , Okafor Ngozi
Published: May 2022

Vaccine acceptance among a large population of people can determine the successful control of the COVID-19 pandemic. We aimed to assess the COVID-19 vaccine acceptance rate and to identify the predicting factors to the non-acceptance of the vaccine in Nigeria up to date. In line with this, PubMed, Web of Science, Cochrane Library, and Embase databases were searched for relevant articles between January 2020 and November 2021 in this rapid review. Ten articles with 9,287 individuals met the inclusion criteria and formed the basis for the final COVID-19 acceptance estimates. A total of ten peer-reviewed articles were reviewed. The vaccine acceptance rate ranged from 20.0% to 58.2% among adults across the six geopolitical zones of the country. Non-acceptance of the vaccine was found to be a result of propaganda, adverse effect concerns, and conspiracy theories. National, community, and individual-level interventions need to be developed to improve the COVID-19 vaccine acceptance rate in the country. Greater efforts could be put in place to address the issues of concern leading to the unwillingness of the people to receive the COVID-19 vaccine. Also, as the pandemic is unfolding, emerging evidence needs to be synthesized and updated.
Optimizing acute stroke outcome prediction models: Comparison of generalized regression neural networks and logistic regressions
Authors: Qu Sheng , Zhou Mingchao , Jiao Shengxiu , Zhang Zeyu , Xue Kaiwen , Long Jianjun , Zha Fubing , Chen Yuan , Li Jiehui , Yang Qingqing , Wang Yulong
Published: May 2022

Background

Generalized regression neural network (GRNN) and logistic regression (LR) are extensively used in the medical field; however, the better model for predicting stroke outcome has not been established. The primary goal of this study was to compare the accuracies of GRNN and LR models to identify the most optimal model for the prediction of acute stroke outcome, as well as explore useful biomarkers for predicting the prognosis of acute stroke patients.

Method

In a single-center study, 216 (80% for the training set and 20% for the test set) acute stroke patients admitted to the Shenzhen Second People’s Hospital between December 2019 to June 2021 were retrospectively recruited. The functional outcomes of the patients were measured using Barthel Index (BI) on discharge. A training set was used to optimize the GRNN and LR models. The test set was utilized to validate and compare the performances of GRNN and LR in predicting acute stroke outcome based on the area under the receiver operating characteristic curve (AUROC), accuracy, sensitivity, and the Kappa value.

Result

The LR analysis showed that age, the National Institute Health Stroke Scale score, BI index, hemoglobin, and albumin were independently associated with stroke outcome. After validating in test set using these variables, we found that the GRNN model showed a better performance based on AUROC (0.931 vs 0.702), sensitivity (0.933 vs 0.700), specificity (0.889 vs 0.722), accuracy (0.896 vs 0.729), and the Kappa value (0.775 vs 0.416) than the LR model.

Conclusion

Overall, the GRNN model demonstrated superior performance to the LR model in predicting the prognosis of acute stroke patients. In addition to its advantage in not affected by implicit interactions and complex relationship in the data. Thus, we suggested that GRNN could be served as the optimal statistical model for acute stroke outcome prediction. Simultaneously, prospective validation based on more variables of the GRNN model for the prediction is required in future studies.
Transcriptomes of testis and pituitary from male Nile tilapia (O. niloticus L.) in the context of social status
Authors: Thönnes Michelle , Prause Rebecca , Levavi-Sivan Berta , Pfennig Frank
Published: May 2022

African cichlids are well established models for studying social hierarchies in teleosts and elucidating the effects social dominance has on gene expression. Ascension in the social hierarchy has been found to increase plasma levels of steroid hormones, follicle stimulating hormone (Fsh) and luteinizing hormone (Lh) as well as gonadosomatic index (GSI). Furthermore, the expression of genes related to gonadotropins and steroidogenesis and signaling along the brain-pituitary-gonad axis (BPG-axis) is affected by changes of an animal’s social status. In this study, we use RNA-sequencing to obtain an in-depth look at the transcriptomes of testes and pituitaries from dominant and subordinate male Nile tilapia living in long-term stable social hierarchies. This allows us to draw conclusions about factors along the brain-pituitary-gonad axis that are involved in maintaining dominance over weeks or even months. We identify a number of genes that are differentially regulated between dominant and subordinate males and show that in high-ranking fish this subset of genes is generally upregulated. Genes differentially expressed between the two social groups comprise growth factors, related binding proteins and receptors, components of Wnt-, Tgfβ- and retinoic acid-signaling pathway, gonadotropin signaling and steroidogenesis pathways. The latter is backed up by elevated levels of 11-ketotestosterone, testosterone and estradiol in dominant males. Luteinizing hormone (Lh) is found in higher concentration in the plasma of long-term dominant males than in subordinate animals. Our results both strengthen the existing models and propose new candidates for functional studies to expand our understanding of social phenomena in teleost fish.
The association between sedentary behaviour, physical activity and type 2 diabetes markers: A systematic review of mixed analytic approaches
Authors: Cavallo Francesca Romana , Golden Caroline , Pearson-Stuttard Jonathan , Falconer Catherine , Toumazou Christofer
Published: May 2022

The negative effect of sedentary behaviour on type 2 diabetes markers is established, but the interaction with measures of physical activity is still largely unknown. Previous studies have analysed associations with single-activity models, which ignore the interaction with other behaviours. By including results from various analytical approaches, this review critically summarises the effects of sedentary behaviour on diabetes markers and the benefits of substitutions and compositions of physical activity. Ovid Medline, Embase and Cochrane Library databases were systematically searched. Studies were selected if sedentary behaviour and physical activity were measured by accelerometer in the general population, and if associations were reported with glucose, insulin, HOMA-IR, insulin sensitivity, HbA1c, diabetes incidence, CRP and IL-6. Forty-five studies were included in the review. Conclusive detrimental associations with sedentary behaviour were determined for 2-h insulin (6/12 studies found associations), fasting insulin (15/19 studies), insulin sensitivity (4/6 studies), diabetes (3/4 studies) and IL-6 (2/3 studies). Reallocating sedentary behaviour to light or moderate-to-vigorous activity has a beneficial effect for 2-h glucose (1/1 studies), fasting insulin (3/3 studies), HOMA-IR (1/1 studies) and insulin sensitivity (1/1 studies). Compositional measures of sedentary behaviour were found to affect 2-h glucose (1/1 studies), fasting insulin (2/3 studies), 2-h insulin (1/1 studies), HOMA-IR (2/2 studies) and CRP (1/1 studies). Different analytical methods produced conflicting results for fasting glucose, 2-h glucose, 2-h insulin, insulin sensitivity, HOMA-IR, diabetes, hbA1c, CRP and IL-6. Studies analysing data by quartiles report independent associations between sedentary behaviour and fasting insulin, HOMA-IR and diabetes only for high duration of sedentary time (7–9 hours/day). However, this review could not provide sufficient evidence for a time-specific cut-off of sedentary behaviour for diabetes biomarkers. While substituting sedentary behaviour with moderate-to-vigorous activity brings greater improvements for health, light activity also benefits metabolic health. Future research should elucidate the effects of substituting and combining different activity durations and modalities.
Elevated aqueous endothelin-1 concentrations in advanced diabetic retinopathy
Authors: Kang Hae Min , Hasanuzzaman Md. , Kim So Won , Koh Hyoung Jun , Lee Sung Chul
Published: May 2022

Purpose

Endothelin-1 (ET-1) is a potent vasoconstrictor which seems to be involved in the pathogenesis of diabetic retinopathy (DR). However, studies on intraocular ET-1 in DR have been limited. Thus, we investigated aqueous ET-1 levels in patients with DR.

Methods

A total 85 subjects were included in this prospective study. Those were classified into three groups: advanced DR group included those with severe nonproliferative DR or proliferative DR, whereas early DR group included those with mild nonproliferative DR or moderative nonproliferative DR. Those who underwent cataract surgery and had no concomitant ocular disease were included in the control group. Aqueous humor levels of ET-1 were obtained before intravitreal bevacizumab injection (IVB) and after 1 month for the DR patients, and at the time of cataract surgery for the control group.

Results

Advanced DR group included 40 eyes (47.1%), whereas early DR group did 19 eyes (22.4%), and control group (26 eyes, 30.5%). Mean aqueous ET-1 level was 10.1±4.1 pg/mL (6.0–21.0 pg/mL) in advanced DR group, 1.9±0.7 pg/mL (0.6–2.8 pg/mL) in early DR group, and 2.1±1.0 pg/mL (0.7–3.9 pg/mL) in control group (P < 0.001). Advanced DR group was further subdivided into severe nonproliferative DR (15 eyes, 12.8%) and proliferative DR (25 eyes, 34.3%). Mean aqueous ET-1 level was 10.1±4.3 pg/mL (6.0–20.1 pg/mL) in patients with severe nonproliferative DR, and 10.0±4.0 pg/mL (6.0–21.0 pg/mL) in those with proliferative DR (P = 0.928) at baseline. Mean ET-1 level at 1 month after intravitreal injection was 2.5±1.0 pg/mL (0.3–4.8 pg/mL) in patients with severe proliferative DR and 2.9±1.7 pg/mL (1.0–7.0 pg/mL) in those with proliferative DR (P = 0.443). Mean aqueous ET-1 level was significantly reduced in both groups (P < 0.001, respectively).

Conclusion

The mean aqueous ET-1 level was significantly higher in the eyes with advanced DR than those with early DR and the control group. The mean aqueous ET-1 level was significantly reduced after intravitreal injections in the advanced DR group. Based on our results, future studies on the exact role of ET-1 in the pathogenesis of DR and future implication for intervention would be helpful for managing DR.
Islamic Art and Architecture in a Contested Region: Negotiating the Muslim Heritage in Meskheti, Georgia
Authors: Kançal-Ferrari Nicole
Published: May 2022

This article draws upon fieldwork carried out in the Meskheti (Ahıska) region of modern Georgia to introduce, analyse, and discuss local mosque architecture. The region’s Islamic art and architecture is largely unknown to the international scholarly community due to a turbulent history, especially in the twentieth century. However, as I show, these mosques shed light on trans-regional and trans-imperial artisan and patronage networks and architectural and aesthetic currents in the nineteenth and early twentieth centuries. Also of interest is the story of how local Muslim communities navigated the complex process of maintaining their religious identity and visible material culture amid the shifting political and social tides in the region during that time, and the fate of the edifices they built after they were forced to leave the region in the mid-twentieth century. Today, much of the Islamic material heritage of Meskheti, Georgia remains under threat. I conclude by considering the current situation of the preservation of historical edifices and offer thoughts on the problems that must be overcome.
The Album of the World Emperor: Cross-Cultural Collecting and the Art of Album-Making in Seventeenth-Century Istanbul, Emine Fetvaci (2019)
Authors: Woodhead Christine
Published: May 2022

Review of: The Album of the World Emperor: Cross-Cultural Collecting and the Art of Album-Making in Seventeenth-Century Istanbul, Emine Fetvaci (2019)

Princeton: Princeton University Press, 296 pp., 126 colour illus.,

ISBN: 9780691189154, $65 (hardback)
What Is ‘Islamic’ Art? Between Religion and Perception, Wendy M. K. Shaw (2019)
Authors: Lenssen Anneka
Published: May 2022

Review of: What Is ‘Islamic’ Art? Between Religion and Perception, Wendy M. K. Shaw (2019)

Cambridge: Cambridge University Press, 366 pp., 52 colour illus.,

ISBN: 9781108622967, $39.99 (hardback)
Material intersections: Image and text in the eighteenth-century commonplace
Authors: Dillard Leigh G.
Published: May 2022

The commonplace book has long provided readers-turned-writers space for textual reflection. In A New Method of Making Common-Place-Books, John Locke asserts a defined schema for the creation of this intentionally usable and personal genre, one more organic than journaling, more deliberate than note-taking. Despite renewed interest in literary ephemera of this sort, the commonplace book collectively remains on the periphery of literary studies, perhaps because the volumes found in today’s libraries reflect such varied experiences. However, it is precisely this variation that reveals insight to the readerly patterns and expectations of the time. Ranging from decorative flourishes and echoes of printers’ marks to richly scrolled title pages and evocative vignettes, the materiality of the commonplace book offered in these moments signals a heightened concern by readers to consider the visual potential of the text as part of their reading experience. This analysis looks at scattered remnants of eighteenth-century commonplace books for compelling examples of image and text relationships that reflect illustrative models from the print market.
Single-stranded DNA aptamer-based rolling circle amplification as anti-chicken Salmonella bacteriostatic
Authors: Hameed Samer Sadeq , Al-Ogaili Adil Sabr , Noori Noor
Published: May 2022

Background and Aim: Salmonella is a major foodborne pathogen in the poultry industry, wherein the control measures may include sanitation and antibacterial and vaccines. However, there have been severe global restrictions on using anti-Salmonella antibacterial agents in livestock. This situation, along with rapidly increasing drug-resistant bacterial species, has led to the exploration of unconventional methods to control Salmonella infection in poultry. In recent years, selection techniques of promising DNA aptamers have begun to permeate several medical branches, resulting in the development of numerous anti-Salmonella DNA aptamers, most of which are used as sensing molecules for diagnostic purposes. These DNA aptamers have been demonstrated to interfere with bacterial growth, multiplication, and viability. Aptamers formed in rolling circle amplification products (RCA-p) could improve the potential action of aptamer interference with bacteria. This study aimed to test the use of single-stranded DNA aptamers in the form of RCA-p as a bacteriostatic to Salmonella in vitro.

Materials and Methods: Salmonella Typhimurium and Salmonella Enteritidis isolates were subjected to the action of anti-ST and anti-SE DNA aptamers in the form of RCA-p. Each isolate was grown on MacConkey and Luria-Bertani agar media separately in different concentrations in the presence or absence of the cognate RCA-p.

Results: The anti-Salmonella species DNA aptamer-based RCA-p were capable of reducing bacterial growth to significant levels in vitro.

Conclusion: We describe a potential solution for the rapidly developing drug resistance of several bacterial species. Our findings suggested that the use of non-toxic, non-immunogenic, and low-cost DNA aptamers targeting Salmonella in the form of RCA-p could inhibit the bacterial growth rate. Unlike polymerase chain reaction, RCA yields tandem repeats of single-stranded DNA at isothermal conditions, which would increase the probability of receptor-ligand clustering and increase affinity. Furthermore, as our RCA template was bivalent with two DNA aptamer sequences, we could target multiple sites or antigens on a bacterial cell.
Isolated facial diplegia variant of Guillain–Barré syndrome with anti-GM1 IgG antibody
Authors: Jung Jin Ho , Lee Sukyoon , Seo Jung Hwa , Bae Jong Seok , Shin Kyong Jin , Kim Jong Kuk , Yoon Byeol-A , Oh Seong-il
Published: May 2022

Facial diplegia (FD) rarely occurs as a regional Guillain-Barré syndrome (GBS) variant. A 70-yearold male presented with bifacial weakness that had started on the left side and extended to the right after several days. He was then treated using steroids and gradually improved. Serum antiganglioside antibody testing revealed positivity for anti-GM1 IgG antibodies. FD can be idiopathic, but it is an uncommon GBS variant. The ganglioside antibody test may increase the possibility of diagnosing isolated FD.
Lumbosacral polyradiculoneuropathy associated with combination therapy of nivolumab and ipilimumab
Authors: Cho Eun Bin , Kim Seung Joo , Yang Tae-Won , Jung Seunguk , Jeong Heejeong , Park Ki-Jong
Published: May 2022

Immune checkpoint inhibitors (ICIs) have emerged as one of the most promising therapeutic options for advanced cancers. While ICIs have improved survival in multiple cancers, their increased use is restricted by various immune-related adverse events. In this report we describe a patient with renal cell carcinoma who received a combination of ICIs, nivolumab plus ipilimumab, and who developed lumbosacral polyradiculoneuropathy. Corticosteroid use was an effective treatment for this patient.
Digestive Health in Sexual and Gender Minority Populations
Authors: Vélez Christopher , Casimiro Isabel , Pitts Robert , Streed Carl , Paul Sonali
Published: May 2022

It has been over 50 years since the Stonewall Inn Riots in June 1969, a seminal event for the lesbian, gay, bisexual, transgender, queer, intersex, and other sexual and gender-diverse minorities (LGBTQI+, or lesbian, gay, bisexual, transgender, queer, intersex, and everyone else) rights movement. However, sexual and gender minority (SGM) individuals still face discrimination and harassment due to their sexual orientation or gender identity. As such, the National Institute on Minority Health and Health Disparities has identified SGM communities as a “health disparity population.” Broadly, there are higher rates of sexually transmitted infections, substance use and abuse, mental health conditions, obesity and eating disorders, certain cancers (breast, cervical, and anorectal), and cardiovascular disease in SGM communities. Transgender patients, especially those of color, are more likely to be uninsured, experience discrimination, and be denied health care than cisgender patients. In addition, SGM individuals have twice the risk of lifetime exposure to emotional, physical, and sexual trauma compared with heterosexuals. It is expected all these factors would negatively affect digestive health as well. This review summarizes the effects of social determinants of health and discrimination on health care access, highlights important digestive diseases to consider in the SGM population, and offers solutions to improve and prioritize the health of these communities. We aim to draw attention to SGM-specific issues that affect gastrointestinal health and spur research that is desperately lacking.
Editorial
Authors: Elías-Caro Jorge Enrique
Published: May 2022

Editorial Memorias 22
Computational Studies of Thiourea Derivatives as Anticancer Candidates through Inhibition of Sirtuin-1 (SIRT1)
Authors: Ruswanto Ruswanto , Mardianingrum Richa , Yanuar Arry
Published: May 2022

Cancer is a disease that starts from the uncontrolled growth of abnormal cells in the organs or tissues of the body, which is the second leading cause of death in the world. One of the targets in discovering and developing anticancer drugs is Sirtuin-1. SIRT1 can act as a tumor suppressor or tumor promoter depending on its target in a particular signalling pathway or on particular cancer. This study aimed to study the interaction of a thiourea derivative with SIRT1 (PDB ID:4I5I) through its inhibition of histone deacetylase. Research has been carried out in silico with molecular docking (MGLTools.1.5.6) and molecular dynamics (Desmond 2019) of three thiourea derivatives to the receptor. In addition, pharmacokinetic parameters, toxicity, and selection of Lipinski's Rule of Five were also tested. Molecular docking results showed that compound b ([2-(methylcarbamothioylcarbamoyl)phenyl]benzoate) had the lowest ∆G value of −9.29 kcal/mol with a KI value of 0.156 µM compared to other thiourea derivatives and was proven by molecular dynamics tests for 30 ns and amino acids that play an active role in the interaction include the residue PheA:297. In terms of pharmacokinetics and toxicity, compound b is better than natural ligands. Compound b is predicted to be used as an anticancer candidate through further research.
Influence of the Electromagnetic Device Aqua 4D on Water Quality and Germination of Lettuce (Lactuca sativa L.)
Authors: Mghaiouini R , Elaouad A , Taimoury H , Sabir I , Chibi F , Hozayn M , Garmim T , Nmila R , Rchid H , Monkade M , Bouari A El , Hozayn M
Published: May 2022

Magnetic water technology has been widely studied and adopted in the field of agriculture in many countries
(Europe, Russia, China, etc….), but in Morocco, the information available on the application of water loving in the
agricultural sector is very limited. In order to show the effect of this technique on plant production under Moroccan
conditions, an experiment was conducted in a culture chamber in the laboratory to study the response of the
germination of lettuce to irrigate with magnetic and tap water under laboratory condition. The analysis of the results
shows a persistent and highly significant improvement through an increase in the germination rate of the order of
45.83% and 55.5 %for treatment with magnetized water treated under the effect of the electromagnetic field Aqua
4D generated by the device for 80 min with renewal of magnetized water germination each 24h and 12 h relative to
the control.
Optical Properties of Zno + 12% ITO Thin Films on Substrates of Anode Aluminum Oxide
Authors: Abbood Nazar Ali
Published: May 2022

ZnO thin films of zinc oxide doped with 12 % ITO (indium tin oxide) on anodic aluminum oxide substrates are formed
in vacuum during high-frequency repetitively pulsed laser deposition. The morphology of films on porous and nonporous surfaces of substrates was studied by atomic force microscopy. The optical properties of the films in the visible,
near, and middle IR regions of the electromagnetic radiation spectrum, the Raman spectra, and also the features of
the photoluminescence characteristics have been experimentally investigated. Zinc oxide films can be used in
optoelectronic transducers, as luminescent material, in the form of transparent electrodes, sensitive layers of gas and
biological sensors, catalysts, X-ray and gamma-radiation detectors.
A Review of RPPVSM based Skin Identification Techniques
Authors: Antony Elizabeth , Kushwaha Madan
Published: May 2022

In recent times, most work on suspect detection, medical science and meteorology has been committed towards
image processing. This paper deals with several biometric characteristics, including face recognition, finger knuckle,
RPPVSM, vein pattern, and fingerprint. RPPVSM differs from the birthmark, because it is genetic but RPPVSM can be
genetic or obtained. The two main parts of RPPVSM are detection and Matching. A duplicate evidence therefore
creates a vein pattern unlikely. In contexts in which images of evidence may display non-facial body sections of
offenders or criminals such as child sexual assault or conflict, relatively permanent Pigmented or Vascular Skin Marks
(RPPVSM) have recently been adopted as biometric recognition attribute. In certain cases, Face Detection is hard to
recognize individuals because adequate facial details are not sufficient. The recognition of manual RPPVSM is
exhausting and time - intensive.
Experimental study on lower cement content (LCC) concrete using continuous packing model: An Eco-Friendly and Sustainable Alternative for Construction Industry
Authors: Tiwari Abhishek , Tyagi Shivam
Published: May 2022

Now a day’s pressure is escalating on the construction industry to adopt more environmentally sustainable methods to reduce CO2 emissions. Portland cement often constitutes to quite two-thirds of the embodied energy of concrete, and its production generates 5% of worldwide greenhouse emission. One efficient strategy to scale back the cement content without sacrificing performance is that the use of particle packing models (PPM) to mix- proportion concrete mixtures with low cement content. This study aims to analyze and quantify the behavior of concrete mixtures designed with the use of the continuous PPM to increase binder efficiency in concrete. Three q factors were selected in this study and properties in the fresh (i.e. slump test) and hardened state (i.e., compressive strength) are measured and analyzed.
The Impact of Green Urban Open Spaces on Enhancing Mental Health
Authors: Salem Alaa Ezzat Abdelkamel , Kamel Hassan , Wageh Dalia
Published: May 2022

Scarcity of green public spaces not only could impair the livability and sustainability of cities but also would affect the public health, while there is potential benefit of green environments on mental health, it could be one of the great reasons of reducing depression and stress, many studies conducted during the last decade suggest the mental health benefits of green spaces , According to the World Health Organization, mental health promotion should include actions that create environments that support mental health and allow people to maintain healthy lifestyles, Given the increase in mental health problems and the ongoing massive urbanization, especially in developing countries, Evidence is growing for the beneficial impacts of natural outdoor environments on health. The general disproportion of urban development and the socio-economic crisis in Egypt followed by a number of acute and chronic stressors, as well as years of accumulated trauma, prevented the parallel physical, mental and social adaptation of society, in addition to a whole and continuous contraction of public green spaces in Cairo certainly affected the quality of mental health, increasing the absolute number of people with depression, stress and psychosomatic disorders.This paper aims to explore and document the development process of Merryland Park, Heliopolis, Cairo, Egypt with specific reference to the conflict between urban development, and mental health.
CFD Analysis on the Effect of the Change in Profile Geometry on Drag Reduction of a Sedan Car
Authors: Sahay Amit , Kumar Ganesh , Shivvedic Kamlesh
Published: May 2022

This study is a 3-dimensional CFD analysis of external aerodynamics of a generic car model. The aim of this study was to visualize the flow field and examine the effect of modification of some geometrical parameter on the drag coefficient of the car body. The reduction in drag allows the vehicle to operate at lower fuel consumption which eventually results in fuel economy and lower pollution. Also artificially guided air maintains stability of vehicles. Therefore, flow field analysis is important for aerodynamic analysis of a car body. The results obtained is compared and validated with existing experimental data and found to be deviated by 5.5%. The two specific name of geometrical parameter for this study which is modified are front bumper angle and hood radius. The three angles are taken into consideration for front bumper angle as 10-degree, 15-degree and 20-degree and at each front bumper angle three hood fillet radius are 200mm, 250mm and 300 mm respectively. It is found in the study that increasing the angle of inclination of front bumper angle decrease the drag coefficient and also increasing the hood fillet radius decreases the drag coefficient. The minimum drag coefficient in the study is found to be 0.3939 at front bumper angle 15 degree and hood fillet radius 300mm. The maximum reduction of the drag coefficient from the base case in which both the parameter is kept at zero-degree angle and zero fillet radius is 6.50%. The flow field suggested that as we increase the inclination angle the frontal projected area is reduced locally and pressure drag is reduced and also giving the fillet at corner the air flow is guided smoothly which also results in reduced drag.
Prediction Rainfall in 2020 in Telangana
Authors: Sharan Anand M
Published: May 2022

Present work uses four separate methods to arrive at the prediction value by taking the average of the results of these four. Here, the calculations are based on past 32 year history of rainfall in Telangana. The four methods are: (1) The Root Mean Square (RMS) values, (2) the Artificial Neural Network (ANN) method, (3) The Fast Fourier Transform (FFT) method, and the Time Series method. Out of these the first and the last methods involve linear regression hence the results obtained exhibit a linear curve. Here, the prediction can be made about 8 months in advance to give sufficient time for planning to the farmers or hydro-electric power generators, or the governments at different levels.
Design of Miniaturized Printed Antenna for Medical Applications
Authors: Raheem Ayat , Aziz Jabir
Published: May 2022

This paper introduces the design, simulation, implementation of miniaturized printed minder line monopole antenna
(PMLMA) in medical application. The proposed antenna operates in Industrial, Scientific, and Medical ISM band.
Antenna has a compact size of (12.25× 7.81 × 0.8) mm3 with -10 return loss printed on FR4 substrate material with
(4.3) dielectric constant and h (0.8) thickness . The proposed antenna is simulated and evaluated using CST microwave
studio package. The propose antenna simulation result obtain that antenna operate on 915MHz frequency with less
than -10dB return loss (-11.237)dB , gain is -18.23dB, band width 20.546MHz and total efficiency -20.64dB. Results of
simulation and implementation show that the proposed antenna possesses an acceptable performances and
miniaturized dimensions, enabling their use in medical applications.
Comparison of ER70S-2 with ER309L in Synthesis of Magnetic Nanoparticles using Arc-Discharge Method
Authors: Hasan Shaik Gulam Abul , Gupta A.V.S S.K.S , Reddi B V
Published: May 2022

Iron-oxide based Magnetic nanoparticles were synthesized using Arc-discharge method in which ER70S-2 and
ER309L weld wires were used as electrodes. In this experiment KCl salt is used as electrolyte due of its easy
availability. While comparing KCl with any other salt, it is found that its reaction rate is high due to which good
quantity of nanoparticles can be produced in very less time. Since the most widely used natural element on earth is
iron, therefore it finds many applications in biomedical and in many other research areas when these particles are in
nano form. Many experiments were carried out using ER70S-2 and ER309L weld wires as electrodes. The obtained
size and chemical composition of the nanoparticles will be discussed briefly using XRD and EDAX characterization
techniques.
A Novel Comparison Study of Modelling Linear Induction Motor using Two Different Dynamic Approaches with Considering the End Effects
Authors: Jaber Fatimah F , Shary Diyah K , Alrudainy Haider
Published: May 2022

Owing to its merits like lower costs, high starting thrust force, easy maintenance, less mechanical losses, silence, high
precision, and so on Linear Induction Motor (LIM) is being increasingly utilized in industries. In this paper, a
comparison between two different mathematical models of a LIM based upon the d-q axes equivalent electrical circuit
has been investigated. This has been accomplished to define the dynamic performance of LIM when considering the end
effects, which can be directly applicable for vector control and drive implementations. The first model separates the
primary and secondary(linor) d-q axis currents into two components, one part is free from end effects while the other
is based on end effects. The second model, however, takes currents without separating them. In the present study, the
linear induction motor responses such as velocity developed thrust, and currents have been simulated and outputted
using the MATLAB/SIMULINK toolbox. The simulation results showed that the approach with separating currents is
superior than the second model in terms of velocity and thrust force by approximately of an 8.5% and 2.6% respectively.
Nanocrystalline Ferrite (MFE2O4) For Photocatalysts and Thermal Properties by Homogeneous Co-Precipitation Technique
Authors: Razaaq Shehbaz  Ahmed , Tubussam Misbah , Fazal Iqra , Akram Misbah
Published: May 2022

In this current research work, the preparation and properties of nickel ferrite nanoparticles were studied. Using
nickel and ferric nitrates and citric acid, NiFe2O4 nanoparticles were prepared by a simple and cost-effective sol-gel
auto-combustion method. The material used for this purpose was in the form of powder and also reagent grade
chemicals were used for this manufacturing. Then the resultant powder was crushed into particles by using mortar
and pestle. The phase formation of the NiFe2O4 was investigated by XRD and SEM techniques. X-ray diffraction (XRD)
measurements were made it possible to approve the structural properties of the prepared samples. The morphology
of these samples was explored through scanning electron microscopy (SEM). Thermal properties were studied by the
thermal analyzer. The photocatalysts in an aqueous solution were studied under directly visible irradiation of the
ferrite sample. After which the photocatalytic activity of the resultant product was observed by UV visible
spectrometer.
Work related Musculoskeletal Disorders among Housewives: Ergonomic issues
Authors: Karandikar Varsha N , Badgujar Pranav R , Malani Krishna M , Rithe Srushti K , Salunke Pranita D
Published: May 2022

In this paper, an extensive survey for research to analyse reasons of musculoskeletal complaints among housewives
was conducted. The objectives of the research were to explore the musculoskeletal disorders which housewives face as
an effect of their daily household activities, to identify the age and percentage of housewives affected and to identify
the commonly involved reasons. These were achieved by collecting the data of 150 housewives (sample size) through
a questionnaire designed by authors based Nordic Musculoskeletal Questionnaire which was circulated among the
housewives. Descriptive statistics were used for data analysis which focused on bar charts, pie charts and tables.
From the collected sample size about 88% of housewives suffered from musculoskeletal complaints. And the most
commonly affected age groups were 31-40 and 41-50 years. The most affected body part was the Lower back (57%).
SEPIC converter of Automatic Power Factor Correction by improved traditional linear control
Authors: Khudhair Manar A , Al-Saffar Alaa A , Jasim Rasheed S
Published: May 2022

With increasing using of nonlinear electronic equipment at a wide range, total harmonics distortion (THD) in the line
current has grown to be a considerable problem. The methods that include reducing harmonics in line current and
power factor correction are required. Therefore, the essential target of this proposed work is to reduce the harmonics
produced in the line current and improve the power quality of the load by the output voltage regulation and power
factor correction (PFC). This paper presents a Single-Ended Primary Inductance Converter (SEPIC) at Discontinuous
Conduction Mode (DCM) for automatic power factor Correction (APFC). The SEPIC converter is modeling by utilizing
Current Injected Equivalent Circuit Approach (CIECA). The control system is applied by traditional linear control (TLC).
The TLC has been modified by an optimization algorithm (OA) and adds an (inner or current). The proposed design of
SEPIC-PFC is implemented by MATLAB and Simulink. According to the simulated dynamic behavior results, a unity
power factor and 15% of total harmonics distortion (THD) reduction have been obtained comparing with previous
work. Besides, a regulated DC output voltage has been achieved. The proposed control system has a low overshoot,
small settling time, and steady-state error close to zero
Design Considerations of Biophilic Design to Improve Human Health and Well-being in Indoor Spaces
Authors: Sayed Nourhan Kamal , Sadik Hamdy , Elnekhaily Fatma
Published: May 2022

We spend 90% of our lives in buildings which means that our health and wellbeing are influenced significantly by the
built environment. Also, there is scarceness of buildings that meet in their design the psychological needs of employees.
Many researchers search about how to connect people with nature to enhance their cognitive performance,
psychological and physiological health. Applying biophilic design patterns to our schools, workplaces, neighborhoods,
and healthcare has profound well-being, health, and financial benefits. So the Buildings owners can collect higher rents;
the workers in healthcare can see economical profits from the faster rates of recovery of patients; organizations more
likely to see improved employees’ productivity and in schools can see an increase in the performance of students and
the rate of absenteeism decreased. This paper aims to highlight the biophilic design patterns, the nature health benefits
and the design considerations needed to achieve these patterns.
Analyzing the Effects of Gravel Pack Completion on Flowpotential in Gas Condensate Well
Authors: Memon Irfan Ali , Tunio Abdul Haque , Bhatti Masood Ahmed
Published: May 2022

Miocene or younger sands are major source of sand production, these type of formations are mostly unconsolidated or
only partially consolidated with soft clay or silt, and these formations are structurally weak. These weak formations
may not detain sand particle movement, and produce along with the hydrocarbon fluids at high rates. This undesirable
sand production can cause many different problems at surface as well as at sub-surface. An effective way of dealing
with this problem is the use of gravel pack technique. However, designing gravel pack treatment requires consideration
of different influencing parameters. This research aims to study the performance of gravel pack along with the gravel
pack height and permeability on the well flow. The approach taken in this study includes the well performance
modeling using a commercial simulator. A filed data is collected for gas condensate well that is being produced from
Lower Goru Massive Sand Formation. The collected field data is simulated to compare the performance of Gas
Condensate well before and after gravel pack completion. With this, the analysis is carried out to determine the effect
of gravel pack height 8 permeability on flow parameters (i.e; flow rates of fluids, sand control losses, frictional losses,
sand control skin, gravel pack critical velocity). Lastly, an appropriate height and permeable gravel is recommended
on the basis of simulation results.
A Review on Additive Layer Manufacturing
Authors: H Alamri Nawaf Mohammad
Published: May 2022

Additive layer manufacturing (ALM) is a process for joining materials to build objects in successive layers under
computer control using data from 3D model. It is an opposite of subtractive manufacturing in which material
removal is required to reach the desired shape. ALM has better capabilities than the original 3D printing that used
mainly for rapid prototyping because it makes the production more efficient if it is used in advanced applications
such as creating highly customized products, producing small volume of serial components and visualizing tool in
design, the future applications may concern human organs creation, clothes manufacturing and food confection. The
aim of this paper is to present a review about ALM showing its application, processes and quality issues focusing on
fused deposition modelling as it is the most traditional ALM process.
Studies on Fresh state behavior on Strength of Concrete
Authors: T Seshadri Sekhar
Published: May 2022

The water/powder ratio remains as essential descriptive statistic for today’s increasingly complex concrete mixtures.
A sample of 200 SCC mixtures of various materials and proportions were fitted with linear regression models. This
Demands a retrospection of well-known Abram’s Water-Cement ratio relation. With this view, as part of an ongoing
research program, an investigation was taken up to study the relationship between Water-Powder ratio and
compressive strength of Self Compacting Concrete.
Influence of basalt and E-glass fiber on mechanical properties of jute reinforced composite material
Authors: Jatin Rathod , Ramakrishna S
Published: May 2022

The current work focuses on investigating mechanical properties of novel material by considering three levels and
three process parameters as input for developing orthogonal array. Based on orthogonal L9 array, nine different
samples were fabricated by hand layup technique and vacuum bagged. The samples were tested for tensile and
hardness. This experimental data is input for minitab software to perform statistical analysis. By considering the best
composition further investigations were conducted by replacing basalt with E-glass to compare. Mechanical
properties were evaluated like flexural in addition to tensile and hardness, and found which material is supporting
high to increase the strength of jute fiber.