bluuebunny/crossref_metadata_2025 huggingface dataset:
A Statistical Procedure for Genome-Wide Detection of QTL Hotspots Using Public Databases with Application to Rice
Authors: Yang Man-Hsia , Wu Dong-Hong , Kao Chen-Hung
Published: December 2018

Genome-wide detection of quantitative trait loci (QTL) hotspots underlying variation in many molecular and phenotypic traits has been a key step in various biological studies since the QTL hotspots are highly informative and can be linked to the genes for the quantitative traits. Several statistical methods have been proposed to detect QTL hotspots. These hotspot detection methods rely heavily on permutation tests performed on summarized QTL data or individual-level data (with genotypes and phenotypes) from the genetical genomics experiments. In this article, we propose a statistical procedure for QTL hotspot detection by using the summarized QTL (interval) data collected in public web-accessible databases. First, a simple statistical method based on the uniform distribution is derived to convert the QTL interval data into the expected QTL frequency (EQF) matrix. And then, to account for the correlation structure among traits, the QTL for correlated traits are grouped together into the same categories to form a reduced EQF matrix. Furthermore, a permutation algorithm on the EQF elements or on the QTL intervals is developed to compute a sliding scale of EQF thresholds, ranging from strict to liberal, for assessing the significance of QTL hotspots. With grouping, much stricter thresholds can be obtained to avoid the detection of spurious hotspots. Real example analysis and simulation study are carried out to illustrate our procedure, evaluate the performances and compare with other methods. It shows that our procedure can control the genome-wide error rates at the target levels, provide appropriate thresholds for correlated data and is comparable to the methods using individual-level data in hotspot detection. Depending on the thresholds used, more than 100 hotspots are detected in GRAMENE rice database. We also perform a genome-wide comparative analysis of the detected hotspots and the known genes collected in the Rice Q-TARO database. The comparative analysis reveals that the hotspots and genes are conformable in the sense that they co-localize closely and are functionally related to relevant traits. Our statistical procedure can provide a framework for exploring the networks among QTL hotspots, genes and quantitative traits in biological studies. The R codes that produce both numerical and graphical outputs of QTL hotspot detection in the genome are available on the worldwide web http://www.stat.sinica.edu.tw/chkao/.
Nacionalidade e democracia: pensando com e contra Marilena Chaui
Authors: Dalaqua Gustavo Hessmann
Published: December 2018

Mediante engajamento crítico com os escritos de Marilena Chaui sobre democracia e nacionalidade, o artigo defende que a nacionalidade é conducente à democracia na medida em que é capaz de criar um grau mínimo de união entre os cidadãos que os permite negociar os vários conflitos que os dividem sem pôr em questão a paridade participativa e o igual pertencimento de todos a um mesmo demos. Após reconstruir a crítica de Chaui à “nacionalidade”, o artigo localiza uma passagem em que a própria filósofa redefine o termo de modo a torná-lo compatível com a democracia. A nacionalidade é compatível com a democracia quando, longe de impor uma representação homogênea e estática do povo que asfixia o conflito e denega a paridade participativa, opera como um referente dinâmico que permite aos cidadãos participar igualmente da política e negociar sem violência os conflitos que os dividem, evitando assim que os diferentes grupos políticos do demos se desintegrem em diferentes demoi. Subscrevendo a definição de Chaui da democracia, o artigo recorre à articulação entre nacionalidade e democracia feita por pensadores políticos das eras moderna e contemporânea (tais quais John Stuart Mill, Friedrich Hertz e David Miller) e sugere que é justamente porque o conflito é um produto inevitável da convivência democrática que a existência de um grau mínimo de união e igualdade entre os cidadãos é indispensável para a manutenção da democracia. Ao satisfazer semelhante exigência, a nacionalidade pode ser considerada conducente à consolidação de uma democracia ao longo do tempo.
Por uma teoria crítica do Direito: um estudo a partir de Walter Benjamin
Authors: Perius Oneide
Published: December 2018

Resumo: O objetivo do presente estudo é promover uma análise dos principais movimentos argumentativos desenvolvidos por Walter Benjamin em seu estudo de 1921 intitulado Zur Kritik der Gewalt. A tarefa proposta para o artigo é a de, a partir disso, apontar a teoria crítica do direito que está sendo proposta no referido texto. Para isso serão analisados, especialmente, os conceitos de direito, justiça, mito e o polissêmico termo Gewalt.
Work addiction: An organizational behavior as well as an addictive behavior?
Authors: Lior Oren , Abira Reizer , Aviv Weinstein
Published: December 2018

In their critical review, Griffiths et al. (2018) discussed 10 myths in the study of work addiction, and addressed the need to conceptualize and investigate this area of research more carefully. In this commentary, we expand their arguments, suggesting that indeed some of the popular myths have solid evidence-based results in the organizational literature. Yet, some of the arguments are only indirectly related to previous organizational findings. Therefore, we emphasize the need to resolve the ambiguities of work addiction, as well as to develop a comprehensive and interdisciplinary understanding of the well-known phenomenon of addictive work behavior.
Moving from the terminology debate to a transdisciplinary understanding of the problem
Authors: Quinones Cristina
Published: December 2018

This commentary considers a recent debate paper which presents and counters 10 work addiction myths. I reflect upon the proposal to move the field forward by distinguishing between, work addiction, which denotes a clinical phenomenon; and workaholism, a term used by the occupational psychology literature with little agreement about its defining dimensions beyond working compulsively. Rather than choosing between these two terms, I argue that addiction experts should lead a transdisciplinary integration of findings from studies where participants report both working compulsively and experiencing significant conflict. I also stress the importance of understanding the macro factors underlying this particular addiction.
Sustainability of the Legal Endowments of Water in Almond Trees and a New Generation of High Quality Hydrosustainable Almonds
Authors: LIPAN Leontina , SÁNCHEZ RODRÍGUEZ Lucía , COLLADO GONZÁLEZ Jacinta , SENDRA Esther , BURLÓ Francisco , HERNÁNDEZ Francisca , VODNAR Dan-Cristian , CARBONELL BARRACHINA Ángel-Antonio
Published: December 2018

The great consumption of water and its scarcity in many areas of the world leads „irremediably” to accept that Spanish agriculture, like other Mediterranean agricultures, must adapt to the lack of this natural resource. Deficit irrigation (DI) strategies are routine practices used worldwide in order to increase net farm income by growing the crops effectiveness to use water. The importance of using this type of strategies is the fact that farmers have the opportunity not just to reduce the water consumption but also to obtain hydro sustainable products. Those are “theoretically” characterized by a high accumulation of secondary carbon metabolites in plant and a great accumulation of bioactive compounds in fruit, according to other studies already done in pistachio or table olives. As almond is the major nut crop in Mediterranean area different DI strategies are presented within this review together with their effect on the final product quality. Thus, the aim of the current review paper is to find all the necessary information about which DI strategies are the recommended to be applied in the almond crop in order to obtain high-quality fruits environmentally friendly. In addition, methods used to determine de quality and steps necessary to certify and protect this type of products are also presented.
Randomized, Open-Label Phase II Study Comparing Capecitabine-Cisplatin Every 3 Weeks with S-1-Cisplatin Every 5 Weeks in Chemotherapy-Naïve Patients with HER2-Negative Advanced Gastric Cancer: OGSG1105, HERBIS-4A Trial
Authors: Kawakami Hisato , Takeno Atsushi , Endo Shunji , Makari Yoichi , Kawada Junji , Taniguchi Hirokazu , Tamura Shigeyuki , Sugimoto Naotoshi , Kimura Yutaka , Tamura Takao , Fujitani Kazumasa , Sakai Daisuke , Shimokawa Toshio , Kurokawa Yukinori , Satoh Taroh
Published: December 2018

Lessons Learned

Evidence has suggested that capecitabine-cisplatin is similar or possibly superior to S-1-cisplatin in terms of safety and efficacy for Japanese patients with advanced gastric cancer (AGC). As far as we are aware, our study is the first randomized trial of two regimens consisting of an oral fluoropyrimidine plus cisplatin in human epidermal growth receptor 2-negative AGC patients with measurable lesions.

Background

We performed a phase II study to evaluate the safety and efficacy of capecitabine plus cisplatin in comparison with S-1 plus cisplatin for first-line treatment of human epidermal growth receptor 2 (HER2)-negative advanced gastric cancer in Japan.

Methods

Eligible patients were randomly assigned to receive either capecitabine at 1,000 mg/m2 twice daily for 14 days plus cisplatin at 80 mg/m2 on day 1 every 3 weeks (n = 43) or S-1 at 40–60 mg twice daily for 21 days plus cisplatin at 60 mg/m2 on day 8 every 5 weeks (n = 41). The primary endpoint of the study was response rate.

Results

Response rate did not differ significantly between the capecitabine-cisplatin and S-1-cisplatin groups (53.5% vs. 51.2%, respectively, p > .999). S-1-cisplatin tended to confer a better progression-free survival (PFS; median of 5.9 vs. 4.1 months, p = .284), overall survival (OS; median of 13.5 vs. 10.0 months, p = .290), and time to treatment failure (TTF; median of 4.5 vs. 3.1 months, p = .052) compared with capecitabine-cisplatin. Common hematologic toxicities of grade 3 or 4 included anemia and neutropenia in both groups. However, anorexia, fatigue, and hyponatremia of grade 3 or 4 occurred more frequently in the capecitabine-cisplatin group.

Conclusion

Capecitabine-cisplatin failed to demonstrate superior efficacy compared with S-1-cisplatin. The higher incidence of severe adverse events with capecitabine-cisplatin suggests that S-1-cisplatin should remain the standard first-line chemotherapy for HER2-negative advanced gastric cancer in Japan.
Relationship between p-multiplier and force ratio at pile head considering non-linear soil–pile interaction
Authors: Su Dong , Yan Wai Man
Published: December 2018

The p-multiplier concept has been widely used to analyse the response of laterally loaded pile groups. Conventionally, the p-multiplier fm is evaluated iteratively by trial and error comparisons of p–y curves and field measurements. However, these approaches could face numerical difficulties and often require subjective adjustment and therefore could result in non-unique solutions. This paper derives a power relationship between fm and the force ratio at the pile head ηhead, defined by the ratio of the lateral force acting at the head of a group pile to that of a single pile, where ηhead equals fm to the power of n. In the case of long piles, it was found that (a) n = 3/4 when the initial modulus of subgrade reaction kini and the ultimate soil resistance pult are constant with depth; and (b) n = 3/5 when both kini and pult increase linearly with depth. This analytical relationship can then be utilised to determine fm from the test results of group piles and single piles, and quickly estimate the lateral bearing capacity of pile groups.
Expression Profiling of Fibroblasts in Chronic and Acute Disease Models Reveals Novel Pathways in Kidney Fibrosis
Authors: Higashi Atsuko Y. , Aronow Bruce J. , Dressler Gregory R.
Published: December 2018

Background

Renal interstitial fibrosis results from activation and proliferation of fibroblasts to myofibroblasts, secretion and accumulation of extracellular matrix, and displacement of normal renal tubules. In contrast to chronic renal disease, acute injury may be repaired, a process that includes a decrease in the number of myofibroblasts in the interstitium and degradation of the accumulated extracellular matrix, leaving little evidence of prior injury.

Methods

To investigate whether activated fibroblasts demonstrate changes in gene expression that correspond with regression after acute injury but are not observed in chronic models of fibrosis, we used microarrays to analyze gene expression patterns among fibroblast populations at different stages of injury or repair. We then mined the data for signaling pathways in fibroblasts corresponding to the acute proliferative, regression, and chronic phases of renal injury.

Results

We identified multiple gene clusters with changes that correlate with the three phases of renal injury, including changes in levels of receptors for the antifibrotic factor PGE2. In adult renal fibroblast cultures, PGE2 was able to upregulate many genes that are suppressed by the profibrotic cytokine TGF-β, whereas many PGE2-downregulated genes were activated by TGF-β. High levels of TGF-β suppressed expression of a subset of PG receptors in fibroblast cultures, making these cells resistant to any effects of PGE2.

Conclusions

Inherent gene expression changes in activated fibroblasts accompany the transition from AKI to repair and regeneration. In chronic models, however, activated fibroblasts are resistant to the antifibrotic effects of PGE2 due to suppression of a subset of PGE receptors.
Ceramic Industry Wastewater Treatment By Chemical Coagulation Process: A Statistical Optimization of Operating Parameters
Authors: SARI ERKAN Hanife
Published: December 2018

This study deals with chemical
oxygen demand (COD) removal from ceramic industry wastewater by chemical coagulation
using alum and ferric chloride (FeCl3) as coagulants. The study also
focuses on the capillary suction time (CST) of sludge samples which is an
important sludge dewatering parameter. Response surface methodology (RSM)
approach was employed to evaluate the effects and interactions of the operating
variables and to optimize the performance of the process. Significant quadratic
polynomial models were obtained (R2 = 96.26% for alum and R2=89.15%
for FeCl3 for COD removal;  R2
= 96.6% for alum and R2=90.9% for FeCl3 for CST of
sludge, respectively). Alum was more effective coagulant for ceramic industry
wastewater treatment as compared with FeCl3. Numerical optimization
based on desirability function was employed; in a 36 min trial 95.2% of COD
removal was achieved at alum dosage of 3.3 g/L and pH 5. The optimization study
shows that the minimum CST of sludge was found 17.4 s at alum dosage of 5 g/L
and pH 5 in a reaction time of 16 min. The results indicate that the RSM is
suitable for the design and optimization of chemical coagulation process using
alum as a coagulant fort he treatment of ceramic industry wastewater.
Optimization of Surface Roughness of AISI 1040 Stainless Steel in Milling Process Using Taguchi Method
Authors: ÖZSOY Neslihan , ÖZSOY Murat
Published: December 2018

Surface
roughness significantly affects the work efficiency and life of machine parts
interacting with each other. There are many parameters that affect surface
roughness such as processed material, cutting tool, cutting parameters, cooling
type. For this reason, optimization of the machining parameters and proper
processing conditions are very important. In this study, the optimum machining
conditions were determined by investigating the surface roughness of the milled
AISI 1040 steel alloy depending on the feed per tooth (0.08 mm/tooth, 0.12
mm/tooth, 0.16 mm/tooth, 0.20 mm/tooth), spindle speed (2000 rpm, 3000 rpm,
40000 rpm, 5000 rpm) and the cooling type (liquid, air) parameters. The Taguchi
experimental design method was used to help achieve results at acceptable
levels and to save time and cost in achieving optimal results. Experiments
designed with the Taguchi method were based on the L16 orthogonal array and
signal / noise (S/N) ratios were used in the evaluation of the experimental
results. The optimum levels of the control factors for minimizing the surface
roughness using S/N rates were determined. The optimal conditions for surface
roughness were observed at A1B1C2 (i.e.,feed per tooth=0.08 mm/tooth and 2000
rpm spindle speed, cooling type=liquid). Variance analysis was also conducted
in the study. According to the results of analyses, it was found that spindle
speed was the most significant parameter for surface roughness. Finally,
confirmation tests were conducted to check the success of the optimization.
La educacion en reglas morales
Authors: Paramo Bernal Pablo
Published: December 2018

Con el propósito de justificar la importancia de educar e investigar sobre la ética en educación, este artículo explora los posibles orígenes del comportamiento moral a partir de la sociobiología y los mecanismos sociales que sostienen esta forma de actuación mediante la regulación verbal y metarreglas. Se analiza esta aproximación frente al estado del arte de la ética en la investigación educativa y las aproximaciones metodológicas que se siguen para llevar a cabo estos estudios. Los resultados de esta exploración indican que hay poco trabajo investigativo en el área, particularmente en Latinoamérica. Entre los trabajos existentes predominan los ensayos de reflexión y, en menor cantidad, la puesta a prueba de modelos teóricos para probar la eficacia de la formación ética del investigador. Se propone educar en reglas morales a los individuos a lo largo de su ciclo vital, en las distintas instituciones sociales y en su experiencia como investigadores, al igual que orientar la investigación hacia la forma más eficiente de formar en reglas morales que conduzcan hacia la autorregulación.
Análise da Mobilidade em Projetos Urbanos: Uma Proposta Metodológica
Authors: Rezende Wagner de Souza , Alvim Angélica A. Tanus Benatti
Published: December 2018

O presente trabalho propõe um conjunto de indicadores para a análise da mobilidade em projetos urbanos, por meio da leitura crítica e adaptação de um processo de certificação de projetos urbanos sustentáveis denominado AQUA (2011). Dentre as diversas categorias analíticas componentes deste processo de certificação, decidiu-se pela utilização da dimensão da mobilidade urbana, composta por oito indicadores, levando-se em conta a escala da intervenção a ser estudada. O objeto escolhido para avaliação foi o Projeto Start, pensado no contexto das intervenções urbanas planejadas nas margens do Rio Piracicaba (2003). É elaborada uma matriz de avaliação dos equipamentos urbanos propostos de acordo com os atributos e suas propriedades, de acordo com os parâmetros estabelecidos na certificação. Conclui-se que existem vantagens na ampliação no uso da certificação AQUA para avaliação de intervenções urbanas, na fase de projeto, principalmente pelo caráter qualitativo dos indicadores utilizados. No entanto, em virtude de esse sistema ser destinado inicialmente à avaliação de condomínios residenciais, algumas adaptações conceituais e metodológicas devem ser consideradas para sua efetiva aplicação em ambientes urbanos consolidados.

PALAVRAS-CHAVE: Projeto Urbano, Indicadores, Mobilidade Urbana, Qualidade de Vida, Piracicaba.
Wetlands: uma alternativa ecológica para o tratamento de efluentes
Authors: Marques Márjori Brenda Leite , Américo-Pinheiro Juliana Heloisa Pinê
Published: December 2018

No Brasil, a falta de saneamento básico como o tratamento de água e esgoto, é uma realidade que ainda persiste em diversas regiões do país, principalmente em áreas rurais onde o efluente doméstico é lançado a céu aberto, poluindo o solo, águas superficiais e subterrâneas, além de contribuir para a proliferação de insetos e doenças de veiculação hídrica. Atualmente, existem inúmeros processos e diferentes modelos para o tratamento de esgoto, tanto individuais como combinados. O tratamento do efluente e seu reuso em unidades habitacionais tornou-se algo importante para alcançar a sustentabilidade hídrica. Os wetlands, também conhecidos como Jardins Filtrantes ou brejos artificiais, são uma alternativa ecológica para dar destino adequado à efluentes domésticos e industriais. Nesta opção de tratamento, a despoluição é realizada por espécies de macrófitas que atuam em simbiose com microrganismos capazes de agir em diferentes contaminantes. O trabalho objetiva-se avaliar o funcionamento e características de modelos de wetlands para o tratamento de efluentes domésticos e industriais pela fitorremediação de plantas aquáticas, por meio de um levantamento bibliográfico acerca de trabalhos que analisaram a eficácia da ação despoluidores de diferentes espécies de plantas. Apesar de utilizar plantas encontradas no meio ambiente, o sistema precisa ser bem projetado, e sua manutenção deve ser contínua, devido a significativa produção de biomassa e crescimento das plantas. Portanto, a utilização de wetlands para o tratamento de água, é uma alternativa ecológica e acessível, que, apesar de exigir manutenção contínua, a água final tratada pode ser utilizada para diversos fins.

PALAVRAS-CHAVE: Fitorremediação. Macrófitas. Esgoto sanitário.
Long term Cryopreservation of Chloroviruses by Infection of Chlorella v4
Authors: R Coy Samantha , Alsante Alyssa , W Wilhelm Steven
Published: December 2018

Contact Dr. Steven Wilhelm (wilhelm@utk.edu) or Samantha Coy (srose16@vols.utk.edu) for additional information regarding this protocol.
FCA general dissociation protocol v1
Authors: Park Jongeun
Published: December 2018

This is the protocol used for FCA_ImmunoP project
Analysis of the time evolution of auditory steady-state responses (ASSR) recorded in rats v2
Authors: Prado Pavel , Martínez-Montes Eduardo , Zañartu Matías
Published: December 2018

Auditory steady-state responses (ASSRs) are brain oscillations locked to the periodic properties of acoustic stimuli. Audiological tests based on the acquisition of ASSR are useful for estimating the hearing sensitivity, mainly because multiple hearing frequencies can be simultaneously assessed, and the auditory response can be objectively detected using statistical tests. Typically, the extraction of the auditory response from the measured signal essentially relies on averaging epochs of the EEG, time-locked to the stimulus. Such a manipulation assumes that the auditory response is steady over time and that averaging increases the signal-to-noise ratio of the measurement. Since the time-domain averaging of epochs within a recording does not allow to discriminate between methodological and physiological related variations in the amplitude of the ASSR, we designed a protocol for analyzing the dynamics of the auditory response during the acquisition procedure. The protocol allows us to compute the ASSR amplitude at a given time window without being compromised by those computed in the preceding EEG segments. In other words, the ASSR amplitudes are extracted from individual epochs, without those epochs being time-domain averaged with the preceding EEG segments. As a result, adaptation and other non-stationary behaviors of the ASSR can be studied.
Modified HMW DNA Isolation from Stramenopiles with Agar Plugs v1
Authors: A Bielinski Vincent , Dupont Chris
Published: December 2018

This protocol is the adaptation of previously published methods for use in isolating intact high molecular weight DNA from stramenopiles for long-read sequencing. The advantages here are minimal amount of centrifugation steps on isolated DNA, as well as the long-term storage of the DNA while in plugs to allow experimental flexibility.
Tip 2 diyabet hastalarında anksiyete ve depresyon riski ve ilişkili faktörler
Authors: SAYIN Seher , SAYIN Serhat , BURSALI Burak , BİLEN İPEK Hatice
Published: December 2018

Amaç: Çalışmamızda dünyada ve ülkemizde önemli bir halk sağlığı sorunu olan, ve prevalansı giderek artan tip 2 diyabetli hastaların anksiyete ve depresyon risklerini belirlemeyi ve bu risklerle ilişkili durumları tespit etmeyi amaçladık.Gereç ve Yöntem: Kesitsel tipteki bu analitik araştırma İç Hastalıkları Polikliniğine başvuran, tip 2 diyabet tanılı 636 hastada gerçekleştirildi. Sosyodemografik veriler için araştırmacılar tarafından hazırlanan anket formu kullanıldı. Hastaların anksiyete ve depresyon risklerini belirlemek için Hastane Anksiyete ve Depresyon Ölçeği (HADÖ) kullanıldı.Bulgular: Çalışmaya katılanların %59,9’u (n=381) kadın, %40,1’i (n=255) erkek, tüm grubun yaş ortalaması 59,98±11,66 yıl idi. Katılanların %48,4’ünde (n=308) anksiyete riski, %67,3’ünde (n=428) ise depresyon riski bulunmakta idi. 60 yaş ve üstünde olanlarda, kadınlarda, ilkokul ve altı eğitimlilerde, ev hanımı veya emekli olanlarda, komorbid hastalığı bulunanlarda ve insülin tedavisi alanlarda anksiyete ve depresyon riski istatistiksel olarak anlamlı derecede daha yüksekti. Evli olanlarda ve sigara içenlerde ise anlamlı derecede daha düşüktü.Sonuç: Çalışmamızda anksiyete ve depresyon riski Tip 2 diyabet hastalarında yüksek bulundu. Bu risk yaş, cinsiyet, medeni durum, eğitim, meslek, komorbidite ve diyabet tedavisi ile ilişkili bulundu. Anksiyete ve depresyon açısından yüksek riskli bulunan hastalar psikiyatri bölümü ile birlikte ele alınarak tedavi edilmelidir..
Antiproliferative effects of Vanilla planifolia leaf extract against breast cancer MCF-7 cells
Authors: Kaliappan Vijaybabu , Kumaravelu Punnagai
Published: December 2018

Background: Breast cancer is the most common cancer disease among females in India and worldwide. This needs a critical research for finding the drugs to treat breast cancer with less side effects. The aim of the present study is to reveal the anti-proliferative effects of vanilla extract against MCF-7 cells.Methods: To reveal anti proliferative effects of vanilla leaf extract, MTT assay, cell cycle analysis and DNA fragmentation assay was performed as per standard protocols.Results: MTT assay showed decrease in cell viability with increase of dose of extract and revealed IC50 value at 31.2µg/ml. DNA fragmentation was seen in extract treated cells.Conclusions: The results of the present study confirm the antiproliferative property of vanilla leaf extract in MCF-7 cells. This study results conclude vanilla leaf extract as an effective plant source medicament for treating breast cancer.
A study on the outcome of various methods of administration of intratympanic dexamethasone in tinnitus of cochlear pathology
Authors: Vivek M. , Gowri Shankar M. , Ponraj Kumar N. , Suresh V.
Published: December 2018

Background: The aim of the study was to compare the outcome of various methods of injecting intra tympanic steroids in patients with tinnitus of cochlear pathology.

Methods: A prospective study was conducted on 56 patients with subjective tinnitus of cochlear pathology who were then divided into three groups. After thorough otological and audiological evaluation using standard questionnaire, ENT examination, pure tone audiometry, tone decay test, tinnitogram, CT scans of temporal bone and brain. Each patient underwent one of the three chosen methods of intra tympanic steroids administration randomly. The methods are 1-Tympanomeatal flap elevationand application of steroid soaked gelfoam sponge; 2-Transtympanic steroid injection; 3-Grommet insertion followed by steroid administration. These methods were performed for subjects with tinnitus of cochlear pathology from 2009 to 2011 at a neurotological clinic at Chennai. After following up on 1st, 3rd and 6 months the observations were statistically analysed.  

Results: Success rate for techniques viz tympanomeatal flap was 70%, transtympanic - 63%, grommet - 50%. But when comparing statistically all the three methods were equally successful.

Conclusions: Intratympanic steroids for tinnitus (cochlear pathology) are a safe, simple and promising treatment option. Though all the methods of intra tympanic steroids injection had similar success rate, the tympanomeatal flap elevation method may be preferred since it can be done in a single sitting. However transtympanic injection remains the easiest and cost effective compared to the other two methods.
Ignis artificiosus. Images of God and the Universe in Rubens’s Depiction of Antique Shields
Authors: Esposito Teresa
Published: December 2018

Rubens’s intellectual pursuits are not new to art historians. Much ink has been spilled to illustrate how much and in which way both the classical heritage and Lipsius’s Neostoic thought influenced his artistic production. This article aligns with this scholarly tradition, by concentrating on a peculiar motif depicted by Rubens on antique shields between 1616 and 1618, and by showing how ancient ekphrasis and Lipsius’s natural philosophy, imbued with Platonic and Hermetic ideas, played a fundamental role in Rubens’s invention of this original and powerful image. The latter represents the embodiment of the laws of nature and God, bringing to mind the theological and philosophical discussions circulating among intellectuals at the beginning of the seventeenth century.
Contested Rights: Clerical and Lay Authority in the Holland Mission
Authors: Geraerts Jaap
Published: December 2018

This article studies eleven conflicts between Catholic nobles and the leaders of the Holland Mission. The nobles claimed the right to nominate and present priests in the clandestine Catholic churches and chapels in their jurisdictions; the apostolic vicars and internuncios refused to grant such privileges to members of the laity. Through the assertion of patronage rights, the Dutch Catholic nobility tried to expand their influence over the Holland Mission and voiced their preference for particular priests. As such, these conflicts offer a window into the inner workings of the Missio Hollandica and the Dutch Catholic community, revealing the complex and dynamic interplay between clergy and laity. Moreover, a number of these quarrels represent early instances of laypeople taking a stance in the battle between Jansenists and their opponents, a larger conflict which eventually lead to a schism in the Catholic Church in the Dutch Republic. This analysis therefore provides a cross-section of the Dutch Catholic community and shows how slowly but surely this community disintegrated into warring factions of clergymen and laypeople.
‘Only the strangest and most horrible cases’: The Role of Judicial Violence in the Work of Jan Luyken
Authors: Van Duijnen Michel
Published: December 2018

In 1685, Dutch Calvinist publishers brought to the market a new edition of the Anabaptist martyrology Het bloedig tooneel. Marketed mainly towards wealthy Dutch Anabaptists, the book included 104 high-quality etchings made by the Amsterdam artist Jan Luyken. Famous for their explicit depiction of executions, these images of martyrdom have been studied and explained mainly with reference to Luyken’s Anabaptist leanings, older illustrated martyrologies, and the textual elements of Het bloedig tooneel. However, Luyken matched his work on martyrdom with an impressive production of secular execution prints that are often indistinguishable from their religious counterparts. Taking these similarities as a point of departure, this article will argue that Luyken’s work was not solely concerned with religious and political views, but also with judicial violence as a visual theme in its own right. Besides partisan or sacred readings of violence, Luyken’s prints framed executions in terms of diversity and specificity, leading to the production of a wide variety of explicit and unique images of beheadings, hangings, and burnings. Within this context, Luyken’s execution prints turned scaffold violence into a marketable theme that was eagerly exploited by Amsterdam publishers across a wide variety of illustrated books.
PARTICIPAÇÃO EM ATIVIDADES DE EDUCAÇÃO PERMANENTE E MUDANÇAS NAS PRÁTICAS ASSISTENCIAIS DE ENFERMAGEM
Authors: Mota Rosana Santos , Silva Valdenir Almeida da , Costa Juliana Cana Brazil , Barros Ângela , Gomes Bruno Pereira , Araújo Renata Pereira Alves
Published: December 2018

Objetivo: identificar fatores associados à motivação e às mudanças nas práticas assistenciais entre profissionais de enfermagem participantes de atividades de educação permanente. Metodologia: pesquisa quantitativa, com 283 profissionais de enfermagem. Os dados foram analisados no programa STATA versão 13. Realizou-se análise descritiva e inferencial. Resultados: 90,46% dos participantes sentem-se motivados a participar das atividades de educação permanente; para 90,81% dos participantes, houve mudança na prática assistencial. A motivação em participar das atividades foi associada positivamente ao sexo feminino, proferir religião, trabalhar no campo da pesquisa por até oito anos e pertencer ao vínculo empregatício celetista. Já as repercussões na prática profissional foram associadas estatisticamente a ser técnico/auxiliar de enfermagem, ser formado há até dez anos e trabalhar no campo da pesquisa por até oito anos. Conclusão: a motivação para participar das atividades de educação permanente entre profissionais de enfermagem caracterizou-se como propulsora de mudanças nas práticas assistenciais da enfermagem.

Descritores: Educação Permanente. Capacitação em Serviço. Equipe de Enfermagem.
Editorial
Authors: Casadei Eliza Bachega , Nunes Mônica Rebecca Ferrari
Published: December 2018

Editorial
Conservação de couve minimamente processada tratada com ácido ascórbico
Authors: Souza Alexandra Goede de , Carvalho Jaqueline , Anami Jéssica Mayumi , Saraiva Fátima Rosangela de Souza
Published: December 2018

O objetivo neste trabalho foi avaliar a conservação pós-colheita da couve minimamente processada, tratada com ácido ascórbico e refrigerada. As folhas foram lavadas, picadas e submetidas aos tratamentos com imersão em água destilada seguida de armazenamento em temperatura ambiente; imersão em água destilada seguida de armazenamento refrigerado (10±1oC e umidade relativa (UR) de 90±5%); imersão em solução de ácido ascórbico na concentração de 2,5% seguida de armazenamento refrigerado (10±1oC e UR de 90±5%); e imersão em solução de ácido ascórbico na concentração de 5% seguida de armazenamento refrigerado (10±1oC e UR de 90±5%). Na colheita e após oito dias de armazenamento, foram avaliados a perda de massa fresca (MF), os sólidos solúveis (SS), a acidez total titulável (AT), a relação SS/AT, o pH e a murcha e o escurecimento aparentes. As maiores perdas de MF, a maior murcha e escurecimento aparentes, menores teores de SS e relação SS/AT ocorreram no tratamento com armazenamento em temperatura ambiente. A aplicação de ácido ascórbico, independente da dose, seguido do armazenamento com refrigeração, promoveu menor murcha e escurecimento aparente do tecido, mantendo a couve apta para o consumo até o oitavo dia do armazenamento.
Valores e entrincheiramento organizacional: um estudo em uma seguradora
Authors: Formiga Ana Paula Timbó , Paiva Luis Eduardo Brandão , Lima Tereza Cristina Batista de , Ferraz Serafim Firmo de Souza
Published: December 2018

Resumo: Neste estudo analisa-se a relação entre os valores no trabalho e o entrincheiramento organizacional, baseando-se nos modelos teóricos de Porto e Pilati (2010), para os valores relativos ao trabalho; e de Rodrigues e Bastos (2012), no tocante ao Entrincheiramento Organizacional. Diante disso, trata-se de uma investigação de natureza quantitativa e descritiva, com base em uma amostra de 102 funcionários de uma seguradora. Os resultados apontaram: as principais recompensas desejáveis no trabalho foram a segurança em poder se sustentar financeiramente e a realização em ser bem-sucedido; e a hierarquia de valores seguiu na seguinte ordem: segurança, realização, conformidade, universalismo/benevolência, autodeterminação/estimulação e poder. Quanto ao Entrincheiramento Organizacional, predominou a percepção das perdas de benefícios pelo indivíduo ao sair da instituição, verificando-se uma relação moderada com a segurança e a estabilidade financeira. De modo geral, os resultados contribuem para suplantar a lacuna da literatura que alinha os valores no trabalho e o Entrincheiramento Organizacional, incentivando o desenvolvimento de pesquisas no campo do comportamento organizacional para os funcionários de seguradoras, por se tratar de uma categoria que sofre, constantemente, com as mudanças no mercado de trabalho.Palavras-chave: Carreira. Entrincheiramento. Seguradora. Trabalho. Valores.Values and Entrenchment Organizational training: a study in an insurance company Abstract: This study analyzes the relationship between values at work and organizational entrenchment, based on the theoretical models of Porto and Pilati (2010), for the values related to work; and Rodrigues and Bastos (2012), regarding Organizational Entrenchment. In the light of this, it is a quantitative and descriptive investigation, based on a sample of 102 employees of an insurer. The results allowed to point out: the main desirable rewards in the work were the security in being able to be supported financially and the accomplishment in being successful; and the hierarchy of values followed in the following order: security, achievement, conformity, universalism/benevolence, self-determination/stimulation, and power. As for Organizational Entrenchment, the perception of the loss of benefits by the individual when leaving the institution prevailed, with a moderate relationship with security and financial stability. In general, the results contribute to overcome the literature gap that aligns work values and Organizational Entrenchment, encouraging the development of research in the field of organizational behavior for insurance employees, because it is a category that is constantly suffering, with the changes in the labor market.Keywords: Career. Entrenchment. Insurance company. Job. Values.
REGULARIZAÇÃO FUNDIÁRIA URBANA: uma análise comparativa legal para o nascimento da propriedade social em São Luís
Authors: Júnior Lourival da Silva Ramos , Souza Priscilla Ribeiro Moraes Rêgo de
Published: December 2018

O presente trabalho pretende fornecer subsídio jurídico ao problema social de posses ilegais no Município de São Luís. Faz uma análise comparativa da regularização fundiária prevista nas Leis Federais n. 11.977/09 e 13.465/17, tomando como referência o Município de São Luís. Contudo, antes de utilizá-la, é necessário conhecer os proprietários na área objeto de regularização fundiária para definição dos procedimentos da lei mais recente. Propõe duas soluções para resolver os problemas sociais de moradia: a primeira é a conversão direta de posse em propriedade, sem esperar o tempo de 05 (cinco) anos, contado do registro do título da legitimação de posse e, a segunda, a possibilidade de esse título servir como garantia de financiamento imobiliário, antes da sua conversão em propriedade.Palavras-chave: Posse, propriedade, regularização fundiária, financiamento bancário.
BACHELARD, G. A poética do espaço. São Paulo: Martins Fontes, 1993.
Authors: Celeri Márcio José , Pereira Marcio Roberto
Published: December 2018

Contrário à Idea de que o espaço da casa represente um objeto, o capítulo I, da Poética do espaço, de Gaston Bachelard, reflete sobre as relações simbólicas pelo viés da relação realidade e imaginação na construção de um ideário marcado pela fenomenologia.
O OLHAR DE DAMIÃO: uma leitura da paisagem na obra “Os Tambores de São Luís”
Authors: Júnior Mozart De Sá Tavares
Published: December 2018

THE DAMIÃO LOOK: a reading of the landscape in the work “Os Tambores de São Luís”LA MIRADA DE DAMIÃO: una lectura del paisaje en la obra “Os Tambores de São Luís”O artigo que se segue tem como objetivo investigar a categoria Paisagem, mais especialmente trazendo à tona as relações entre Arte e Ciência, ou seja, da Literatura e da Geografia. Para este trabalho ser cumprido utilizei o romance de Josué Montello, Os Tambores de São Luís, como base fundamental. Levando em consideração o apreço do escritor por São Luís, trouxe o personagem Damião para cá, com a expectativa de representar seus sentimentos, experiências e memórias, como forma de representação simbólicas da categoria acima citada. Este trabalho só pode ser realizado muito em função dos teóricos da Geografia Humanista, que deram uma luz nas interpretações de categorias geográficas.Palavras-chave: Paisagem; Literatura; Geografia Humanista; Josué Montello.ABSTRACTThe following article aims to investigate the Landscape category, more especially bringing to the fore the relations between Art and Science, that is, Literature and Geography. For this work to be fulfilled I used the novel by Josué Montello, Os Tambores de São Luís, as a fundamental basis. Taking into account the writer's appreciation for São Luís, he brought the character Damião here with the expectation of representing his feelings, experiences and memories, as a symbolic representation of the category mentioned above. This work can only be done very much according to the theorists of Humanist Geography, who have shed light on the interpretations of geographic categories.Keywords: Landscape; Literature; Humanist Geography; Josué Montello.RESUMENEl artículo tiene como objetivo investigar la categoría Paisaje, más especialmente trayendo a la luz las relaciones entre Arte y Ciencia, es decir, entre la Literatura y la Geografía. Para este trabajo se utilizó como base fundamental la novela de Josué Montello, Os Tambores de São Luís. Poniendo en consideración el aprecio del escritor por São Luís, presenta al personaje Damião, com la expectativa de representar sus sentimentos, experiências y memorias, como forma de representación simbólica de las categorias citadas arriba. Este trabalho sólo puede ser analizado en el marco de las teorías de la Geografía Humanista, que da el sustento a la interpretación de las categorías geográficas indagadas. Palabras clave: Paisaje; Literatura; Geografía Humanista; Josué Montello.
SALECL, Renata. Sobre a felicidade: ansiedade e consumo na era do hipercapitalismo. Tradução de Marcelo Rezende. São Paulo: Alameda, 2005.
Authors: Ruiz Nícolas Veregue
Published: December 2018

Este livro de Renata Salecl, filósofa e socióloga eslovena, foi-me apresentado na disciplina de Ensino de Geografia e Estágio de Vivência Docente, do Curso de Licenciatura em Geografia, em 2015, e, desde então, tanto a leitura, quanto a resenha crítica escrita e avaliada pela docente responsável da referida disciplina, tem me perseguido e inspirado nas práticas acadêmicas, docentes e também pensares para minha vida pessoal.
Explorando los perfiles de los estudiantes de liceos de Montevideo. Un análisis comparativo para orientar la inclusión
Authors: Nakasone Arashiro Graciela Edith
Published: December 2018

El objetivo de este estudio es examinar cinco áreas del perfil de los estudiantes que se hallan en la etapa de transición entre el primer ciclo de educación secundaria y el segundo y su relación con el proceso de inclusión. Los datos fueron recolectados por medio de cinco cuestionarios psicométricos adaptados, reestructurados y validados para su uso en población estudiantil uruguaya. Se halló que 36 de las 46 variables investigadas generaron desigualdades de diferente magnitud. Esto señala la vulnerabilidad de las trayectorias estudiantiles a los factores contextuales así como las necesidades específicas de los procesos académicos. Los resultados del análisis correlacional y multivariante mostraron que las cinco áreas del desarrollo se interrelacionan y que las trayectorias más vulnerables se hallan asociadas a un conjunto de factores que denotan los contextos socioeconómicos de procedencia. Los componentes del desarrollo presentan diferentes grados de sensibilidad a los factores de riesgo, de lo que se extrae que mayor grado de sensibilidad exige coordinar intervenciones más complejas. La interrelación de las áreas es además susceptible a la acumulación progresiva de componentes positivos en situaciones favorables y negativos en situaciones desfavorables. Esto es particularmente visible en los procesos del rezago educativo y de las expectativas de estudios y plantea que detectar el momento en el que se inicia el fracaso escolar es clave para prevenir la deserción educativa.
EFFICIENCY OF USE OF PLASMOLIFTING IN IMPLANTATION IN PATIENTS WITH INFLAMMATORY DISEASES OF A PARODONT
Authors: Temkin E. S , Dorozhkina L. G , . Kremneva D. S
Published: December 2018

There is a problem of replacement of defects of a tooth alignment by means of implants at patients with diseases of a parodont. Work on elimination of the available inflammatory phenomena of a parodont and acceleration of an engraftment of implants of PEEK Optima by means of introduction of a platelet autoplazma is carried out. Using a technique of Plasmolifting, was succeeded to achieve positive results (decrease in inflammatory processes, elimination of bleeding, acquisition by a gum of physiological coloring, acceleration of an engraftment of implants, decrease in sensitivity to infections, a complete recovery of function, esthetic quality).
THE ROLE OF LABORATORY BIOMARKERS IN MONITORING THE EFFECTIVENESS OF TREATMENT WITH INHIBITORS OF TUMOR NECROSIS FACTOR а IN RHEUMATOID ARTHRITIS
Authors: Dotsenko S. S , Shilova L. N , Alexandrov A. V , Bakumov P. A
Published: December 2018

Currently there are several biological therapy drugs used in the treatment of rheumatoid arthritis (RA), in connection with which there was a problem of choosing a drug. Materials and methods. 18 patients with rheumatoid arthritis, who received combination therapy with methotrexate and infliximab were examined. All patients before the start of treatment with infliximab and after 30 weeks were determined in the blood serum of TNF-α, IL-1, IL-2, IL-6. Results and conclusions. Hyperproduction of proinflammatory cytokines again confirms their participation in the development and progression of the RA. Increased levels of TNF-α, IL-1, IL-2 are more likely associated with a moderate effect of the conducted gene therapy at minimal and medium therapeutic dosages.
SOLUTION OF THE SYSTEM OF NAVIER–STOKES EQUATIONS LINEARIZED WITH RESPECT TO THE VELOCITY WITH REGARD OF A POWER-LOW DEPENDENCE OF VISCOSITY, THERMAL CONDUCTIVITY AND THE GASEOUS MEDIUM DENSITY ON THE TEMPERATURE
Authors: Malai Nikolai Vladimirovich , Samoilova Nadezhda Nikolaevna
Published: December 2018

We received the solution of the system of Navier–Stokes equations linearized with respect to the velocity in the spheroidal coordinate system with regard of a power-law dependence of viscosity, thermal conductivity and the gaseous medium density on the temperature by means of generalized power series.
The impact of dental anxiety and dental fear on the periodontal status and quality of life among dental patients
Authors: Penteado Luiz Alexandre Moura , Pinho Roberto Carlos Mourão , Santos Natanael Barbosa dos , Vajgel Bruna de Carvalho Farias , Cimões Renata
Published: December 2018

Aim: The aim of the study was to investigate levels of Dental Fear (DF) and Dental Anxiety (DA) among individuals awaiting appointments at the clinics of two courses in dentistry and determine the impact on oral health status and quality of life. Methods: An observational study was conducted with a sample of adult dental patients. Levels of DF and DA and the perception of quality of life were determined using questionnaires and periodontal data. Results: Among the 287 subjects, 71.4% were female, 7.3% were classified as very anxious and 16% were classified as anxious. Gender was significantly associated with DA (p = 0.001); 20% of the female volunteers and 6.1% of the males were classified as anxious. The frequency of moderate and extreme fear was 42.9% and was not significantly correlated with gender (p = 0.071). The prevalence of a negative impact from oral health status on quality of life (measured using the OHIP-14 scale) was 38.3% and income was significantly associated with this outcome (p = 0.000). Conclusion: Levels of DA and DF were substantial among the individuals analyzed. Women with a lower education were susceptible to anxiety. DA and DF were  associated with periodontal status or impact on quality of life.