bluuebunny/crossref_metadata_2025 huggingface dataset:
Time-Loss Injuries in Karate: A Prospective Cohort Study of 4 Consecutive World Karate Championships
Authors: Augustovičová Dušana , Lystad Reidar P. , Arriaza Rafael
Published: August 2019

Background:

Prospective studies on injuries in martial arts competitions are scarce, especially those involving time-loss injuries. The upsurge of karate athletes competing in top-level karate competitions warrants elucidation of the time-loss injury risk.

Purpose:

To determine the time-loss injury proportion and incidence rate, describe the injury pattern among elite senior karate athletes, and compare the risk of time-loss injuries in male versus female athletes and in individual (ie, weight categories) versus team competitions (free-weight category).

Study Design:

Descriptive epidemiology study.

Methods:

Data were collected at 4 consecutive World Karate Championships (2010, 2012, 2014, and 2016). Injury incidence rates were calculated per 1000 athlete-exposures (IIRAE) and per 1000 minutes of exposure (IIRME), with 95% CIs. Subgroups were compared by calculating their rate ratios with 95% CIs.

Results:

A total of 506 injuries were recorded, of which 51 were time-loss injuries (10%). The overall time-loss injury rate was significantly lower for female versus male athletes and slightly lower for team versus individual competitions. Overall, 1.4% of all athletes sustained a time-loss injury, and the IIRAE and IIRME were 5.13 (95% CI, 3.82-6.74) and 1.98 (95% CI, 1.47-2.60), respectively. The most common type of time-loss injury was fracture (41%), followed by dislocation (20%) and concussion (12%).

Conclusion:

The time-loss injury incidence rate for top-level karate competitions found in this prospective study was relatively low. Comprehensive knowledge about the incidence of time-loss injuries during karate competitions represents an essential basis to develop effective strategies for injury prevention. Thus, the introduction of a uniform injury surveillance system in martial arts is of utmost importance.
Framing Equitable Classroom Practices: Potentials of Critical Multimodal Literacy Research
Authors: Cappello Marva , Wiseman Angela M. , Turner Jennifer D.
Published: August 2019

This article presents an illustrative case study to explore the classroom potentials of critical multimodal literacy. We feature Marcela’s multimodal response to demonstrate how she engaged with visual and textual tools for learning. Illustrative cases are especially useful to explore a particular issue and often involve in-depth analysis of qualitative data that represents theoretical constructs or significant findings. Critical multimodal literacy is a framework that we developed from a synthesis of the research literature to describe the ways that children use tools (e.g., sketches, videos) for personal meaning-making, critique, and agentive learning in classrooms. Findings from the critical analysis of a young Latina fourth-grader’s multimodal production illuminate our framework, which consists of the following four components: communicate and learn with multimodal tools; restory, represent, and redesign; acknowledge and shift power relationships; and leverage multimodal resources to critique and transform sociopolitical realities all seen through an equity lens. We conclude with implications for how this critical multimodal literacy framework can promote equitable classroom practices that expand the literacy learning of all students.
Trajectory of hippocampal fibres to the contralateral anterior thalamus and mammillary bodies in rats, mice, and macaque monkeys
Authors: Mathiasen Mathias L. , Louch Rebecca C. , Nelson Andrew D. , Dillingham Christopher M. , Aggleton John P.
Published: August 2019

The routes by which the hippocampal formation projects bilaterally to the anterior thalamic nuclei and mammillary bodies were examined in the mouse, rat, and macaque monkey. Despite using different methods and different species, the principal pattern remained the same. For both target areas, the contralateral hippocampal (subiculum) projections arose via efferents in the postcommissural fornix ipsilateral to the tracer injection, which then crossed hemispheres both in or just prior to reaching the target site within the thalamus or hypothalamus. Precommissural fornix fibres could not be followed to the target areas. There was scant evidence that the ventral hippocampal commissure or decussating fornix fibres contribute to these crossed subiculum projections. Meanwhile, a small minority of postsubiculum projections in the mouse were seen to cross in the descending fornix at the level of the caudal septum to join the contralateral postcommissural fornix before reaching the anterior thalamus and lateral mammillary nucleus on that side. Although the rodent anterior thalamic nuclei also receive nonfornical inputs from the subiculum and postsubiculum via the ipsilateral internal capsule, few, if any, of these projections cross the midline. It was also apparent that nuclei within the head direction system (anterodorsal thalamic nucleus, laterodorsal thalamic nucleus, and lateral mammillary nucleus) receive far fewer crossed hippocampal inputs than the other anterior thalamic or mammillary nuclei. The present findings increase our understanding of the fornix and its component pathways while also informing disconnection analyses involving the hippocampal formation and diencephalon.
Cost assessment of urban sprawl on municipal services using hierarchical regression
Authors: Gielen Eric , Riutort-Mayol Gabriel , Miralles i Garcia José Luis , Palencia Jiménez José Sergio
Published: August 2019

In Europe, especially in the Valencian Community, Spain, the growth of cities in the last few decades has brought with it a major paradigm change, shifting from a compact to a sprawling urban model. Although it is known about its important environmental, social, and economic effects, there is no clear and unequivocal measurement of the impact of urban sprawl on municipal spending. The impact of the sprawling city on public finances and on the cost of local public services is clearly one of the conditioning factors that should be assessed when making urban development decisions. Based on a measurement of the sprawling city, our aim is to calculate the effect of urban sprawl on the local administration’s expenditure and particularly on the cost of basic public municipal services. These are obtained through a statistical model with cost functions that can assess the increase in spending prompted by urban sprawl for municipal current expenditure. The proposed model is novel in the field of urban planning and is based on a Bayesian hierarchical model with the ability to include modeling constraints among the expenditures variables and handle missing values accurately. With this paper, we show that urban sprawl has a significant and positive effect on the unit cost of local public services, which results in an inefficient urban growth model from the economic point of view. The effect is not transferred homogeneously to the budget. There are spending items that are more sensitive to urban sprawl like expenditure on security and public transportation and community wellbeing, which primarily covers waste collection, elimination, and treatment; sanitation, and water supply and distribution; road cleaning; and public lighting.
Automatic glioma segmentation based on adaptive superpixel
Authors: Wu Yaping , Zhao Zhe , Wu Weiguo , Lin Yusong , Wang Meiyun
Published: August 2019

Background

The automatic glioma segmentation is of great significance for clinical practice. This study aims to propose an automatic method based on superpixel for glioma segmentation from the T2 weighted Magnetic Resonance Imaging.

Methods

The proposed method mainly includes three steps. First, we propose an adaptive superpixel generation algorithm based on simple linear iterative clustering version with 0 parameter (ASLIC0). This algorithm can acquire a superpixel image with fewer superpixels and better fit the boundary of region of interest (ROI) by automatically selecting the optimal number of superpixels. Second, we compose a training set by calculating the statistical, texture, curvature and fractal features for each superpixel. Third, Support Vector Machine (SVM) is used to train classification model based on the features of the second step.

Results

The experimental results on Multimodal Brain Tumor Image Segmentation Benchmark 2017 (BraTS2017) show that the proposed method has good segmentation performance. The average Dice, Hausdorff distance, sensitivity, and specificity for the segmented tumor against the ground truth are 0.8492, 3.4697 pixels, 81.47, and 99.64%, respectively. The proposed method shows good stability on high- and low-grade glioma samples. Comparative experimental results show that the proposed method has superior performance.

Conclusions

This provides a close match to expert delineation across all grades of glioma, leading to a fast and reproducible method of glioma segmentation.
30-days effects of vildagliptin on vascular function, plasma viscosity, inflammation, oxidative stress, and intestinal peptides on drug-naïve women with diabetes and obesity: a randomized head-to-head metformin-controlled study
Authors: Schiapaccassa Alessandra , Maranhão Priscila A. , de Souza Maria das Graças Coelho , Panazzolo Diogo G. , Nogueira Neto José Firmino , Bouskela Eliete , Kraemer-Aguiar Luiz Guilherme
Published: August 2019

Background

Obesity is the main risk factor for diabetes and excessive visceral fat triggers low-grade inflammatory process, mediated by activation and release of cytokines and high flow of free fatty acids that contribute to insulin resistance, increased oxidative stress, and impaired endothelial function. Metformin and vildagliptin have known vasculoprotective actions, but the value of these drugs on drug-naïve diabetic patients during 30 days use warrants investigation. Our purpose was to observe their effects on endothelial function, oxidative stress, inflammatory biomarkers, and plasma viscosity.

Methods

38 women with obesity and type 2 diabetes drug-naïve, aged between 19 and 50 years, BMI ≥ 30 kg/m2, were recruited and subjected to measurements of endothelial function, nutritive skin microvascular reactivity, plasma viscosity, inflammatory and oxidative stress biomarkers at baseline and randomized 1:1 to ingest metformin (850 mg twice/day) or vildagliptin (50 mg twice/day) during 30 days, and then, re-evaluated.

Results

No differences between groups were noticed at baseline. After treatment, vildagliptin promoted an improvement on endothelial-dependent and -independent vasodilatations, at arteriole level, while metformin resulted in improved nutritive microvascular reactivity, at the capillary level. Intragroup analysis showed that vildagliptin reduced insulin, C-peptide and oxidized LDL, and increased adiponectin and glucagon-like peptide-1 while metformin reduced weight, plasma glucose, total cholesterol, HDL-c, LDL-c, and dipeptidyl peptidase-4 activity, with an unexpected increase on tumor necrosis factor-α. No significant difference in plasma viscosity was noted.

Conclusions

In the vascular beds investigated, both drugs used for only 30 days improved endothelial function, through distinct, and possibly, complementary mechanisms on drug-naïve diabetic women.

Trial Registration ClinicalTrials.gov: NCT01827280
Evaluating Psychosocial Mechanisms Underlying STEM Persistence in Undergraduates: Scalability and Longitudinal Analysis of Three Cohorts from a Six-Day Pre–College Engagement STEM Academy Program
Authors: Kuchynka Sophie , Findley-Van Nostrand Danielle , Pollenz Richard S.
Published: August 2019

In a previous report, we validated that a cohort of first-year undergraduates who participated in a weeklong pre–college engagement STEM Academy (SA) program were retained in science, technology, engineering, and mathematics (STEM) at a higher rate than a matched comparison group (MCG). In addition, SA students yielded increases in science identity and sense of belonging to STEM and to the university. Here, we report the ability to scale the size of the SA program to accommodate more students and replicate the previous findings with two additional cohorts. Longitudinal analysis of the 2015 and 2016 program cohorts demonstrate that both groups were retained to STEM disciplines and the university at higher rates than a MCG. To assess what underlying psychological mechanisms lead to increases in science identity and university belonging, we tested three exploratory models. These models indicate that positive changes in university and STEM belonging indirectly predict an increase in science identity. Further, positive changes in perceived family support indirectly predict increases in university belonging. Thus, through the evaluation of three different cohorts, we found robust evidence that the SA program increases sense of belonging and science identity, and these attitudinal changes promote undergraduate persistence in STEM.
Optimizing the finite-difference implementation of three-dimensional free-surface boundary in frequency-domain modeling of elastic waves
Authors: Cao Jian , Chen Jing-Bo
Published: August 2019

The problem of modeling seismic wave propagation for multiple sources, such as in the solution of gradient-based elastic full-waveform inversion, is an important topic in seismic exploration. The frequency-domain finite-difference (FD) method is a good choice for this purpose, mainly because of its simple discretization and high computational efficiency. However, when it comes to modeling the complete elastic wavefields, this approach has limited surface-wave accuracy because, when modeling with the strong form of the wave equation, it is not always easy to implement an accurate stress-free boundary condition. Although a denser spatial sampling is helpful for overcoming this problem, the additional discrete points will significantly increase the computational cost in the resolution of its resulting discrete system, especially in 3D problems. Furthermore, sometimes, when modeling with optimized schemes, an inconsistency in the computation precision between the regions at the free surface and inside the model volume would happen and introduce numerical artifacts. To overcome these issues, we have considered optimizing the FD implementation of the free-surface boundary. In our method, the problem was formulated in terms of a novel system of partial differential equations satisfied at the free surface, and the weighted-averaging strategy was introduced to optimize its discretization. With this approach, we can impose FD schemes for the free surface and internal region consistently and improve their discretization precision simultaneously. Benchmark tests for Lamb’s problem indicate that the proposed free-surface implementation contributes to improving the simulation accuracy on surface waves, without increasing the number of grid points per wavelength. This reveals the potential of developing optimized schemes in the free-surface implementation. In particular, through the successful introduction of weighting coefficients, this free-surface FD implementation enables adaptation to the variation of Poisson’s ratio, which is very useful for modeling in heterogeneous near-surface weathered zones.
A two-stage Markov chain Monte Carlo method for seismic inversion and uncertainty quantification
Authors: Stuart Georgia K. , Minkoff Susan E. , Pereira Felipe
Published: August 2019

Bayesian methods for full-waveform inversion allow quantification of uncertainty in the solution, including determination of interval estimates and posterior distributions of the model unknowns. Markov chain Monte Carlo (MCMC) methods produce posterior distributions subject to fewer assumptions, such as normality, than deterministic Bayesian methods. However, MCMC is computationally a very expensive process that requires repeated solution of the wave equation for different velocity samples. Ultimately, a large proportion of these samples (often 40%–90%) is rejected. We have evaluated a two-stage MCMC algorithm that uses a coarse-grid filter to quickly reject unacceptable velocity proposals, thereby reducing the computational expense of solving the velocity inversion problem and quantifying uncertainty. Our filter stage uses operator upscaling, which provides near-perfect speedup in parallel with essentially no communication between processes and produces data that are highly correlated with those obtained from the full fine-grid solution. Four numerical experiments demonstrate the efficiency and accuracy of the method. The two-stage MCMC algorithm produce the same results (i.e., posterior distributions and uncertainty information, such as medians and highest posterior density intervals) as the Metropolis-Hastings MCMC. Thus, no information needed for uncertainty quantification is compromised when replacing the one-stage MCMC with the more computationally efficient two-stage MCMC. In four representative experiments, the two-stage method reduces the time spent on rejected models by one-third to one-half, which is important because most of models tried during the course of the MCMC algorithm are rejected. Furthermore, the two-stage MCMC algorithm substantially reduced the overall time-per-trial by as much as 40%, while increasing the acceptance rate from 9% to 90%.
Safety and Efficacy of T-DM1 Plus Neratinib in Patients With Metastatic HER2-Positive Breast Cancer: NSABP Foundation Trial FB-10
Authors: Abraham Jame , Montero Albert J. , Jankowitz Rachel C. , Salkeni Mohamad Adham , Beumer Jan H. , Kiesel Brian F. , Piette Fanny , Adamson Laura M. , Nagy Rebecca J. , Lanman Richard B. , Sperinde Jeff , Huang Weidong , Allegra Carmen J. , Srinivasan Ashok , Wang Ying , Pogue-Geile Katherine L. , Lucas Peter C. , Jacobs Samuel A.
Published: August 2019

PURPOSE

Patients with human epidermal growth factor receptor 2 (HER2)–positive metastatic breast cancer eventually develop resistance to dual-antibody therapy with trastuzumab plus pertuzumab. Mechanisms of resistance have not been well elucidated. We evaluated the safety, tolerability, and efficacy of ado-trastuzumab emtansine (T-DM1) plus neratinib in patients who progressed on trastuzumab plus pertuzumab.

PATIENTS AND METHODS

In this 3 + 3 dose-escalation study, patients with metastatic breast cancer who progressed on trastuzumab, pertuzumab, and a taxane were treated with T-DM1 at 3.6 mg/kg intravenously every 3 weeks and dose-escalating neratinib at 120, 160, 200, or 240 mg/d orally.

RESULTS

Twenty-seven patients were treated across four dose-levels of neratinib. Dose-limiting toxicity in cycle 1 was grade 3 diarrhea in six patients and grade 3 nausea in one; no patient experienced grade 4 diarrhea, and there were no grade 5 toxicities. Other grade 3 to 4 toxicities included nausea (11%), dehydration (11%), electrolyte abnormality (19%), thrombocytopenia (15%), elevated transaminase levels (7%), and fatigue (7%). Twelve (63%) of 19 evaluable patients had an objective response. Responses occurred at all neratinib doses. Plasma cell–free DNA at baseline showed ERBB2 (HER2) amplification in 10 of 27 patients. Deep and more durable responses occurred in patients with cell-free DNA ERBB2 amplification. Two complete responders had high expression of total HER2 and p95HER2 in baseline tissue.

CONCLUSION

We report the recommended phase II dose of T-DM1 3.6 mg/kg and neratinib 160 mg/d for this combination. Possible resistance mechanisms to HER2 antibodies may be loss of the HER2 receptor and high expression of p95HER2. These data provide the basis for an ongoing phase II study to better define the activity of this regimen.
Computed Tomography–Based Biomarker Outcomes in a Prospective Trial of Preoperative FOLFIRINOX and Chemoradiation for Borderline Resectable Pancreatic Cancer
Authors: Koay Eugene J. , Katz Matthew H.G. , Wang Huamin , Wang Xuemei , Prakash Laura , Javle Milind , Shroff Rachna , Fogelman David , Avila Santiago , Zaid Mohamed , Elganainy Dalia , Lee Yeonju , Crane Christopher H. , Krishnan Sunil , Das Prajnan , Fleming Jason B. , Lee Jeffrey E. , Tamm Eric P. , Bhosale Priya , Lee Jeffrey H. , Weston Brian , Maitra Anirban , Wolff Robert A. , Varadhachary Gauri R.
Published: August 2019

PURPOSE

Effective preoperative regimens and biomarkers for pancreatic ductal adenocarcinoma (PDAC) are lacking. We prospectively evaluated fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX)-based treatment and imaging-based biomarkers for borderline resectable PDAC.

METHODS

Eligible patients had treatment-naïve, histology-confirmed PDAC and one or more high-risk features: mesenteric vessel involvement, CA 19-9 level of 500 mg/dL or greater, and indeterminate metastatic lesions. Patients received modified FOLFIRINOX and chemoradiation before anticipated pancreatectomy. Tumors were classified on baseline computed tomography as high delta (well-defined interface with parenchyma) or low delta (ill-defined interface). We designated computed tomography interface response after therapy as type I (remained or became well defined) or type II (became ill defined). The study had 80% power to differentiate a 60% from 40% resection rate (α = .10). Overall survival (OS) and progression-free survival (PFS) were estimated using the Kaplan-Meier method, and subgroups were compared using log-rank tests.

RESULTS

Thirty-three patients initiated therapy; 45% underwent pancreatectomy. The median OS was 24 months (95% CI, 16.2 to 29.6 months). For patients who did and did not undergo pancreatectomy, the median OS was 42 months (95% CI, 17.7 months to not estimable) and 14 months (95% CI, 9.0 to 24.8 months), respectively. Patients with high-delta tumors had lower 3-year PFS (4% v 40%) and 3-year OS rates (20% v 60%) than those with low-delta tumors (both P < .05). Patients with type II interface responses had lower 3-year PFS (0% v 29%) and 3-year OS rates (16% v 47%) than those with type I responses (both P < .001).

CONCLUSION

Preoperative FOLFIRINOX followed by chemoradiation for high-risk borderline resectable PDAC was associated with a resection rate of 45% and median OS of approximately 2 years. Our imaging-based biomarker validation indicates that personalized treatment may be achieved using these biomarkers at baseline and post-treatment.
Shifting roles of Drosophila pair-rule gene orthologs: segmental expression and function in the milkweed bug Oncopeltus fasciatus
Authors: Reding Katie , Chen Mengyao , Lu Yong , Jarvela Alys M. Cheatle , Pick Leslie
Published: August 2019

The discovery of pair-rule genes (PRGs) in Drosophila revealed the existence of an underlying two-segment-wide prepattern directing embryogenesis. The milkweed bug Oncopeltus, a hemimetabolous insect, is a more representative arthropod: most of its segments form sequentially after gastrulation. Here we report the expression and function of orthologs of the complete set of nine Drosophila PRGs in Oncopeltus. Seven Of-PRG-orthologs are expressed in stripes in the primordia of every segment, rather than every-other segment, Of-runt is PR-like, and several are also expressed in the segment addition zone. RNAi-mediated knockdown of Of-odd-skipped, paired and sloppy-paired impacted all segments, with no indication of PR-like register. We confirm that Of-E75A is expressed in PR-like stripes, although it is not PR in Drosophila, demonstrating the existence of an underlying PR-like prepattern in Oncopeltus. These findings reveal that a switch occurred in regulatory circuits leading to segment formation: while several holometabolous insects are “Drosophila-like,” utilizing PRG-orthologs for PR-patterning, most Of-PRGs are expressed segmentally in Oncopeltus, a more basally-branching insect. Thus, an evolutionarily stable phenotype – segment formation – is directed by alternate regulatory pathways in diverse species.
Ground reaction forces of overground galloping in ridden Thoroughbred racehorses
Authors: Self Davies Zoe T. , Spence Andrew J. , Wilson Alan M.
Published: August 2019

The horse has evolved to gallop economically at high speed. Limb force increases with speed but direct measures of limb ground reaction forces (GRFs) at gallop are sparse. This study reports GRFs for multiple limbs, using force plates, across seven Thoroughbred racehorses during ridden galloping. The results show peak vertical GRF values of 13.6 N kg−1 (non-lead hindlimb), 12.3 N kg−1 (lead hindlimb), 14.0 N kg−1 (non-lead forelimb) and 13.6 N kg−1 (lead forelimb) at 11.4 m s−1 and recorded values are consistent with those predicted from duty factor. The distribution of body weight between the forelimbs and hindlimbs is approximated to 50:50, and is variable with speed, unlike the 60:40 commonly stated for cursorial quadrupeds in the literature. An even distribution of load on all limbs may help minimise accumulation of fatigue and assist in injury avoidance. Cranio-caudal force data concur with the observation that horses apply a net accelerative impulse with the hindlimbs and a net decelerative impulse with the forelimbs. Capturing GRFs enhances our knowledge on the mechanics of galloping in fast-moving species and provides insight into injury risk and factors limiting athletic performance.
Planning Online Advertising Using Gini Indices
Authors: Lejeune Miguel A. , Turner John
Published: August 2019

Advertisers engaged in brand-building activities online often purchase significant volumes of impression-based online advertising (e.g., banner ads or video ads) from website publishers or their ad-technology partners who schedule and deliver online advertisements. Such advertising is typically targeted, which means that ads can only be shown to specific audience segments chosen by the advertiser (e.g., urban females from any U.S. city). In general, advertisers are not well served by publishers who further constrain an ad campaign’s targeting (e.g., by delivering disproportionately many impressions of urban females from Los Angeles and not from other cities). In “Planning Online Advertising Using Gini Indices,” Miguel Lejeune and John Turner consider a new objective function for spreading impressions of online advertising across targeted audience segments. The authors show how the Gini Index, which economists use to measure wealth or income inequality, can be deployed within a publisher’s optimization model to minimize the weighted sum of Gini indices across all ad campaigns, and thus maximally spread impressions across targeted audience segments, while limiting demand shortfalls. Key properties and solution structure are compared to a popular existing non-Gini-based ad spreading model developed at Yahoo, and a novel optimization-based decomposition scheme is developed to efficiently solve the Gini-allocation problem. Finally, the authors illustrate how Lorenz curves may be used to visualize Gini-based spread so that managers can effectively monitor the performance of a publisher's ad delivery system.
Functional analysis of a de novo mutation c.1692 del A of the PHEX gene in a Chinese family with X-linked hypophosphataemic rickets
Authors: Huang Jianbo , Bao Xiaogang , Xia Wenjun , Zhu Lingjun , Zhang Jin , Ma Jing , Jiang Nan , Yang Jichun , Chen Qing , Jing Tianrui , Liu Jia , Ma Duan , Xu Guohua
Published: August 2019

Objectives

X-linked hypophosphataemic rickets (XLHR) is a disease of impaired bone mineralization characterized by hypophosphataemia caused by renal phosphate wasting. The main clinical manifestations of the disorder are O-shaped legs, X-shaped legs, delayed growth, and bone pain. XLHR is the most common inheritable form of rickets, with an incidence of 1/20 000 in humans. It accounts for approximately 80% of familial cases of hypophosphataemia and serves as the prototype of defective tubular phosphate (PO43+) transport, due to extra renal defects resulting in unregulated FGF23 activity. XLHR is caused by loss-of-function mutations in the PHEX gene. The aim of this research was to identify the genetic defect responsible for familial hypophosphataemic rickets in a four-generation Chinese Han pedigree and to analyze the function of this mutation.

Methods

The genome DNA samples of all members in the pedigree were extracted from whole blood. We sequenced all exons of the PHEX and FGF23 genes, as well as the adjacent splice site sequence with Sanger sequencing. Next, we analyzed the de novo mutation c.1692 del A of the PHEX gene with an online digital service and investigated the mutant PHEX with SWISS-MODEL, immunofluorescence, and protein stability detection.

Results

Through Sanger sequencing, we found a de novo mutation, c.1692 del A, in exon 16 of the PHEX gene in this pedigree. This mutation can make the PHEX protein become unstable and decay rapidly, which results in familial XLHR.

Conclusion

We have found a de novo loss-of-function mutation, c.1692 del A, in exon 16 of the PHEX gene that can cause XLHR. Cite this article: J. Huang, X. Bao, W. Xia, L. Zhu, J. Zhang, J. Ma, N. Jiang, J. Yang, Q. Chen, T. Jing, J. Liu, D. Ma, G. Xu. Functional analysis of a de novo mutation c.1692 del A of the PHEX gene in a Chinese family with X-linked hypophosphataemic rickets. Bone Joint Res 2019;8:405–413. DOI: 10.1302/2046-3758.88.BJR-2018-0276.R1.
Timing Games with Irrational Types: Leverage-Driven Bubbles and Crash-Contingent Claims
Authors: Matsushima Hitoshi
Published: August 2019

This study investigates strategic aspect of leverage-driven bubbles from the viewpoint of game theory and behavioral finance. Even if a company is unproductive, its stock price grows up according to an exogenous reinforcement pattern. During the bubble, this company raises huge funds by issuing new shares. Multiple arbitrageurs strategically decide whether to ride the bubble by continuing to purchase shares through leveraged finance.

We demonstrate two models that are distinguished by whether crash-contingent claim, i. e. contractual agreement such that the purchaser of this claim receives a promised monetary amount if and only if the bubble crashes, is available. We show that the availability of this claim deters the bubble; without crash-contingent claim, the bubble emerges and persists long even if the degree of reinforcement is insufficient. Without crash-contingent claim, high leverage ratio fosters the bubble, while with crash-contingent claim, it rather deters the bubble.

We formulate these models as specifications of timing game with irrational types; each player selects a time in a fixed time interval, and the player who selects the earliest time wins the game. We assume that each player is irrational with a small but positive probability. We then prove that there exists the unique Nash equilibrium; according to it, every player never selects the initial time. By regarding arbitrageurs as players, we give careful conceptualizations that are necessary to interpret timing games as models of leverage-driven bubbles.
Pragmatics in the interpretation of scope ambiguities
Authors: Apresjan Valentina
Published: August 2019

This paper presents a corpus study of pragmatic factors involved in interpreting potentially ambiguous sentences with negation and universal quantifiers, as demonstrated by the Russian sentenceOni ne uspejut vsjo eto sdelat’‘They won’t have time to do all this.’ Ambiguity in such sentences results from potential differences in scope assignment. If negation scopes over the quantifier, we get the interpretation of partial negation: ‘They will manage to do some of these things, but not everything.’ If negation scopes over the verb, we get total negation: ‘They won’t manage to do anything.’

This study is based on Russian and English data extracted from a variety of corpora. We demonstrate that while syntactic conditions where scope ambiguity is possible are different for Russian and English, in situations when both languages allow it, speakers rely on the same pragmatic mechanisms for disambiguation that are based on Gricean cooperation principle and shared background knowledge. Disambiguation is facilitated by lexical markers, different for verb-negated and quantifier-negated readings, and similar in Russian and English. We show that the interpretation of the quantifier is pragmatically different for verb-negated and quantifier-negated readings (emphatic in the former case and quantificational in the latter), and lexical markers of each reading are semantically and pragmatically consistent with this difference. Namely, verb-negated readings occur primarily in the context of demonstrative pronouns in their pragmaticalized meaning of negative assessment and negatively connoted nouns, while quantifier-negated readings occur in the context of verbs with quantitative semantics and quantitative implicatures that consolidate the interpretation of quantification.
Dependency parsing of Polish
Authors: Wróblewska Alina , Rybak Piotr
Published: August 2019

The predicate-argument structure transparently encoded in dependency-based syntactic representations supports machine translation, question answering, information extraction, etc. The quality of dependency parsing is therefore a crucial issue in natural language processing. In the current paper we discuss the fundamental ideas of the dependency theory and provide an overview of selected dependency-based resources for Polish. Furthermore, we present some state-of-the-art dependency parsing systems whose models can be estimated on correctly annotated data. In the experimental part, we provide an in-depth evaluation of these systems on Polish data. Our results show that graph-based parsers, even those without any neural component, are better suited for Polish than transition-based parsing systems.
Sentiment analysis for Polish
Authors: Wawer Aleksander
Published: August 2019

This article is a comprehensive review of freely available tools and software for sentiment analysis of texts written in Polish. It covers solutions which deal with all levels of linguistic analysis: starting from word-level, through phrase-level and up to sentence-level sentiment analysis. Technically, the tools include dictionaries, rule-based systems as well as deep neural networks. The text also describes a solution for finding opinion targets. The article also contains remarks that compare the landscape of available tools in Polish with that for English language. It is useful from the standpoint of multiple disciplines, not only information technology and computer science, but applied linguistics and social sciences.
Semantic approach for building generated virtual-parallel corpora from monolingual texts
Authors: Wołk Krzysztof , Wołk Agnieszka , Marasek Krzysztof
Published: August 2019

Several natural languages have undergone a great deal of processing, but the problem of limited textual linguistic resources remains. The manual creation of parallel corpora by humans is rather expensive and time consuming, while the language data required for statistical machine translation (SMT) do not exist in adequate quantities for their statistical information to be used to initiate the research process. On the other hand, applying known approaches to build parallel resources from multiple sources, such as comparable or quasi-comparable corpora, is very complicated and provides rather noisy output, which later needs to be further processed and requires in-domain adaptation. To optimize the performance of comparable corpora mining algorithms, it is essential to use a quality parallel corpus for training of a good data classifier. In this research, we have developed a methodology for generating an accurate parallel corpus (Czech-English, Polish-English) from monolingual resources by calculating the compatibility between the results of three machine translation systems. We have created translations of large, single-language resources by applying multiple translation systems and strictly measuring translation compatibility using rules based on the Levenshtein distance. The results produced by this approach were very favorable. The generated corpora successfully improved the quality of SMT systems and seem to be useful for many other natural language processing tasks.
Emergency Department Pediatric Readiness and Mortality in Critically Ill Children
Authors: Ames Stefanie G. , Davis Billie S. , Marin Jennifer R. , Fink Ericka L. , Olson Lenora M. , Gausche-Hill Marianne , Kahn Jeremy M.
Published: August 2019

BACKGROUND:

Emergency departments (EDs) vary in their level of readiness to care for pediatric emergencies. We evaluated the effect of ED pediatric readiness on the mortality of critically ill children.

METHODS:

We conducted a retrospective cohort study in Florida, Iowa, Massachusetts, Nebraska, and New York, focusing on patients aged 0 to 18 years with critical illness, defined as requiring intensive care admission or experiencing death during the encounter. We used ED and inpatient administrative data from the Agency for Healthcare Research and Quality’s Healthcare Cost and Utilization Project linked to hospital-specific data from the 2013 National Pediatric Readiness Project. The relationship between hospital-specific pediatric readiness and encounter mortality in the entire cohort and in condition-specific subgroups was evaluated by using multivariable logistic regression and fractional polynomials.

RESULTS:

We studied 20 483 critically ill children presenting to 426 hospitals. The median weighted pediatric readiness score was 74.8 (interquartile range: 59.3–88.0; range: 29.6–100). Unadjusted in-hospital mortality decreased with increasing readiness score (mortality by lowest to highest readiness quartile: 11.1%, 5.4%, 4.9%, and 3.4%; P < .001 for trend). Adjusting for age, chronic complex conditions, and severity of illness, presentation to a hospital in the highest readiness quartile was associated with decreased odds of in-hospital mortality (adjusted odds ratio compared with the lowest quartile: 0.25; 95% confidence interval: 0.18–0.37; P < .001). Similar results were seen in specific subgroups.

CONCLUSIONS:

Presentation to hospitals with a high pediatric readiness score is associated with decreased mortality. Efforts to increase ED readiness for pediatric emergencies may improve patient outcomes.
Physicochemical characteristics of cacao (Theobroma cacao L.) soils in Colombia: Are they adequate to improve productivity?
Authors: León-Moreno Clara Esperanza , Rojas-Molina Jairo , Castilla-Campos Carlos E.
Published: August 2019

In Colombia, cacao farms are located mainly in areas with edaphoclimatic limitations. The predominant soil fertility characteristics from small cacao farms in 13 provinces were evaluated. A total of 635 soil samples (0-20 cm) were taken between 2011 and 2013 from the main cacao producer regions in Colombia. The number of samples was assigned based on the regional cacao production. The resulting data were analyzed with a linear regression model using pH as the dependent variable and soil chemical and physical parameters as the independent variables. Soil texture ranged between 14 and 40% clay, and 31 and 65% sand. Bulk density ranged between 1.07 and 1.28 Mg m-3 with a calculated porosity between 48.8 and 55.0%. There was no evidence of soil compaction. The national pH ranged between 3.9 and 7.9 and was negatively correlated with Al+3 content (R2 = 0.68) and Al saturation (R2 = 0.80) and redicts Al saturation in the range of available Al up to pH >5.2- 5.5. In this range, available P (as P2O5) was lower than 12 mg kg-1 and was accepted as a minimum value for a sustainable production. With 4.0 cmolc kg-1 of Ca and 60% saturation of the effective cation exchange capacity (ECEC). A minimum ECEC is proposed at 6.0 cmolc kg-1. A reference table for soils in Colombia is proposed as a guide for the establishment and management of productive and sustainable plantations.
Phosphate fertilization on soils with improved fertility in the Brazilian Cerrado
Authors: Mariussi Luís Marcelo , Da Costa Leite Rubson , Araújo de Freitas Gilson , Da Costa Leite Robson , Martins dos Santos Antônio Carlos , Da Silva Carneiro Jefferson Santana , Ribeiro da Silva Rubens
Published: August 2019

The practices of soil amendment and fertilization carried out over the years have allowed the improvement of the fertility in some of them in the Brazilian soils. The objective of this study was to evaluate the performance of soybean in response to phosphate fertilization in soil with improved fertility. The research was carried out during the 2015-2016 harvest season in a dry-land area in the municipality of São Desidério, Bahia. The experiment was arranged in randomized blocks, with five treatments and four replicates. Treatments were composed by doses of phosphate fertilizer (0, 70, 140, 210 and 280 kg P2O5 ha-1). The following variables were evaluated: plant height, height of insertion of the first pod, number of stems per plant, number of pods per plant, thousand grain weight, productivity, and the analysis of macro and micronutrients in the leaf. Soybean plants did not respond to phosphorus applied to soil with built fertility. Under the conditions of this study, phosphorus fertilization in soil with improved fertility did not promote productivity. Although the plants did not respond to foliar macro and micronutrients as a function of phosphate fertilization, there was no reduction of these in response to high doses.
Potential of a Cladosporium cladosporioides strain for the control of Tetranychus urticae Koch (Acari: Tetranychidae) under laboratory conditions
Authors: Gámez-Guzmán Angie , Torres-Rojas Esperanza , Gaigl Andreas
Published: August 2019

The two spotted spider mite Tetranychus urticae is an important polyphagous pest worldwide. It is able to adapt to a wide variety of environments and has a high reproduction rate. In practice, farmers try to reduce losses by using synthetic acaricides. However, frequent and inadequate applications of acaricides have made this mite resistant to many active ingredients, creating the need to search for alternative control strategies. The aim of this research was to identify and to evaluate an indigenous strain of a fungus, which eliminated a T. urticae colony in a greenhouse. The isolated fungus was identified through a morphological and molecular characterization as Cladosporium cladosporioides. Thereafter, the mites were treated with five concentrations of C. cladosporioides conidia (2x104, 2x105, 2x106, 2x107, and 2x108 conidia ml-1) and a positive control (commercial Beauveria bassiana strain, 1x106 conidia ml-1). After 10 d, all treatments achieved at least 50% control; the concentrations 2x107 and 2x108 spores ml-1 controlled 73.3% and 81.7%, respectively, surpassing the commercial strain slightly (72.3%). TL50 ranged between 5 (2x108 spores ml-1) and 8 (2x104 spores ml-1) d, and LC50 was 1.95x106. The possible acaricidal effect of this strain on these mites is discussed.
Effect of pollen doses on fruit formation and oil production in two hybrid palm genotypes (Elaeis oleifera H.B.K. Cortes x Elaeis guineensis Jacq.)
Authors: Socha Jéssica , Cayón Daniel , Ligarreto Gustavo , Chaves Gabriel
Published: August 2019

OxG oil palm hybrids (Elaeis oleifera x Elaeis guineensis) produce a small number of male inflorescences, with an irregular, slow anthesis phase and low-viability pollen that affect natural pollination, making the agronomic practice of assisted pollination necessary for plantations in order to guarantee the formation of the majority of bunch fruits. In the hybrids “Coarí x La Mé” and “(Sinú x Coarí) x La Mé”, the influence of several doses of pollen (0, 0.01, 0.05, 0.1, 0.15 g/inflorescence) on bunch weight, normal and parthenocarpic fruits, fruit set and oil/bunch potential was studied. A completely randomized experimental design was used with four replicates and nine inflorescences/replicate. The bunch weight was higher with the 0.05 g/inflorescence dose and lower with the natural pollination. The greatest fruit set was obtained with the dose of 0.1 g/inflorescence, and the oil/bunch percentage was higher with 0.05 g/inflorescence and lower with 0.01 g/inflorescence. The results confirm the need for assisted pollination in these new hybrid materials.
Effect of climate variability on Collaria scenica (Hemiptera: Miridae) on the Bogotá plateau
Authors: Rodríguez-Roa Andrea , Arce-Barboza Blanca , Boshell-Villamarin Francisco , Barreto-Triana Nancy
Published: August 2019

The aim of this research was to study the effect of climatic conditions on the population of the grass bug Collaria scenica (Stal, 1859) using agroclimatic models and analyzing its behavior under interannual variability scenarios related to El Niño-Southern Oscillation (ENSO) events. The population fluctuations of this grass bug were modeled, estimating significant climatic variables in the presence of nymphs and adults with a multiple linear regression analysis. The population distribution of this insect in relation to the occurrence of the El Niño and La Niña phenomena on the Bogota plateau was analyzed based on variations of the sea surface temperature (SST) in the tropical Pacific and their impact on climate variables. The maximum and minimum temperatures, precipitation and evapotranspiration showed higher significance for this pest than the other variables. The optimal growth and development conditions for this grass bug occurred during periods with a higher daily thermal amplitude and high precipitation values, which highlights the positive effect of abundant, but not excessive, rain. This study helped to determine the population growth during the two seasons of the year with higher rainfall in the area, which correspond to March-May (MAM) and September-November (SON), mainly in the following season after the dry quarter of December-February (DJF). Important increases occur in the El Niño event because of the greater accumulation of heat units during this phenomenon based on increases in air temperature that favor insect growth.
Inventarios de bienes del siglo XVII en la comunidad hebrea de Livorno (italia): Nivelación entre español y portugués
Authors: Perdiguero Villarreal Hermógenes
Published: August 2019

En este estudio se analizan documentos notariales pertenecientes a la comunidad hebrea de Livorno (Italia) del siglo XVII, formados por testamentos e inventarios de bienes principalmente, que muestran interferencias de otras lenguas en textos escritos en español. Tras mostrar las circunstancias del éxodo de judíos españoles y portugueses, se revisan los estudios llevados a cabo sobre el contacto del español y el portugués y los principios del contacto de lenguas. Se dedica especial atención al análisis de la presencia de elementos del portugués en el testamento de una mujer, viuda de un sefardita portugués para observar el proceso de nivelación lingüística en tales documentos.
English Language Teaching in Colombia: A Necessary Paradigm Shift
Authors: Le Gal Damien
Published: August 2019

In a first step, this article presents a reflection on the current state of the teaching of English as a Foreign Language (EFL) in Colombia. Analysing teachers’ certification and teacher training, methodologies, language policies, and materials used, the textdiscusses how these processes essentially relies on technology importation. In a second step, the article introduces the sociocritical approach (SA), a recent development in Foreign Language Teaching which would contribute to the aforementioned issue since SA implies a shift in current policies from a private to a public orientation, from a top-down to a bottom-up approach in order to implement a context-based and adapted English Language Teaching (ELT) in Colombia.