bluuebunny/crossref_metadata_2025 huggingface dataset:
CDX-2 expression correlates with clinical outcomes in MSI-H metastatic colorectal cancer patients receiving immune checkpoint inhibitors
Authors: Ziranu Pina , Pretta Andrea , Pozzari Marta , Maccioni Antonio , Badiali Manuela , Fanni Daniela , Lai Eleonora , Donisi Clelia , Persano Mara , Gerosa Clara , Puzzoni Marco , Bardanzellu Fabio , Ambu Rossano , Pusceddu Valeria , Dubois Marco , Cerrone Giulia , Migliari Marco , Murgia Sara , Spanu Dario , Pretta Gianluca , Aimola Valentina , Balconi Francesca , Murru Stefania , Faa Gavino , Scartozzi Mario
Published: August 2022

Background
Immune checkpoint inhibitors (ICIs) showed efficacy in metastatic colorectal cancer (mCRC) with mismatch-repair deficiency or high microsatellite instability (dMMR-MSI-H). Unfortunately, a patient’s subgroup did not benefit from immunotherapy. CDX-2 would seem to influence immunotherapy’s sensitivity, potentially being a biomarker of ICIs efficacy. Therefore, we investigated its role as a prognostic-predictive marker in patients with mCRC MSI-H.
Materials and Methods
We retrospectively collected data from 14 MSI-H mCRC patients treated with ICIs between 2018 and 2021. The primary endpoint was the Progression-Free-Survival (PFS) rate at 12 months. The secondary endpoints were Overall Survival (OS), PFS, objective response rate (ORR), and disease control rate (DCR).
Results
The PFS rate at 12 months was 80% in CDX-2-positive patients vs 0% in CDX-2-negative patients (p = 0.003). The median PFS was not reached (NR) in the CDX-2-positive group versus 2.07 months (95%CI 2.07to10.8) in CDX-2-negative patients (p = 0.0003). Median OS was NR in CDX-2-positive patients versus 2.17 months (95%CI 2.17to18.7) in CDX2-negative patients (p = 0.0262). All CDX-2-positive patients achieved a disease response, one of them a complete response. Among CDX-2-negative patients, one achieved stable disease, while the other progressed rapidly (ORR:100%v0%, p = 0.0005; DCR: 100%vs50%, p = 0.02). Pembrolizumab in the first-line did not reach the median PFS, and it achieved a median PFS of 10.8 months (95%CI 10,8to12,1; p = 0.04) in third-line treatment.
Conclusion
Our analysis confirms the prognostic role of CDX-2 in CRC and suggests a promising predictive role in defining the immuno-sensitive population. Modulating the CDX-2/CXCL14 axis in CDX-2-negative patients could be useful in overcoming primary resistance to immunotherapy.
On the stability of Lord Shulman thermoelastic system with porous damping
Authors: Boudeliou Marwa , Bouraoui Hamed Abderrahamne , Djebabla Abdelhak
Published: August 2022

In this work, we study the asymptotic behavior of a one-dimensional Lord-Shulman thermoelastic system [1]. We establish the well-posedness and the stability of the system by using the energy method. We present a finite element approximation and we show the discrete energy decay. At the end, numerical simulations are presented to validate the theoretical results.AMS Subject Classification: 435B37, 35L55, 74D05, 93D15.
An Anonymous Lightweight Mutual Authentication Scheme for Fog Computing
Authors: S Thankaraja Raja , Harish R. , Veni T.
Published: August 2022

An identity preserving mutual authentication scheme between fog users and fog servers is an important and challenging issue in fog computing, because unlike cloud servers, fog servers and fog users may be malicious. Such a scheme should retain the true identity of the user from the opponent, because otherwise, the opponent will be able to track which fog user and fog server are communicating. This article proposes a safe and effective anonymous mutual authentication scheme between the fog user and the fog server at the edge of the network. In our solution, with the help of the registration authority (RA), they can authenticate each other and agree on a new session key, which will be used to encrypt messages in the session. Fog users can roam freely in the network and can authenticate to any fog server within its range without re-registering with RA. The proposed scheme requires few symmetric encryption/decryption and one-way hash functions, so that it can be efficiently implemented for resource-constrained fog user’s devices. The performance of the proposed scheme is compared with the existing scheme, in which the proposed scheme can withstand multiple attacks (known plaintext attacks, man-in-the-middle attacks, session hijacking, etc.). Finally, the proposed scheme is verified using the widely accepted Automated Validation of Internet Security Protocols and Applications (AVISPA) tool. The results show that our protocol can safely resist various attacks and can achieve the expected goals. Moreover, the proposed scheme is practically experimented using the NS3 simulator.
Comparative Analysis of (1 + λ)Evolutionary Algorithms Based on Comparison-in-time Model
Authors: Feng Fujian , Zhou Zhulian , Tan Mian , Xia Dawen , Wang Lin
Published: August 2022

Runtime comparative analysis of evolutionary algorithms (EAs) is an important topic in the theoretical research of evolutionary computation. Few studies have been conducted to compare the performance of the runtime analysis. The runtime of EAs can be measured by the first hitting time (FHT) to find the optimal solution. In this paper, we present the design of an equal-in-time model based on the stochastic process model of FHT and the property of equivalence relation, which realizes by expected FHT (EFHT) equivalence class division of difference EAs. With the equal-in-time model, we propose a comparison-in-time model, which can directly compare and analyze the EFHT of different EAs. To verify the feasibility of the proposed comparison-in-time model on a multi-individual population, we conducted a case study to analyze the performance of (1 + λ)EA with different selection operators and different variation operators. Experimental results show that the proposed comparison-in-time model is applicable to the comparison of (1 + λ)EA and is consistent with the comparative analysis results of (1 + 1)EA.
Improving the Effectiveness of Teacher Assessment in Higher Education: A Case Study of Professors’ Perceptions in Morocco
Authors: Rasmy Aziz , St-Amand Jérôme , Abdessamed Nabil , Courdi Clémentine
Published: August 2022

Teacher assessment in higher education is a widely used strategy in Western countries, but it is not common practice in Moroccan academia. In consequence, the establishment of a new assessment policy in higher education creates a new dynamic in teaching practices, teacher assessment and professional career development. This type of major change, however, is likely to generate anxiety among staff regarding the learning of new practices, and uncertainty in respect of their involvement in the process of teacher assessment. The objective of the present study was thus to explore the perceptions of professors concerning the implementation of teacher assessment in Moroccan universities (Mohamed V University and Ibn Tofeil), through a survey and interviews carried out among the professors. The majority of professors expressed a positive attitude towards the usefulness of teaching evaluation. According to them, teacher assessment helps them identify strengths and weaknesses in their teaching. In contrast, there is a recurring issue among the respondents, namely the crisis of trust towards the parties involved in the evaluation process and apprehension regarding consequences of these evaluations’ results on faculty status and rank progression. The majority were very suspicious of using student assessment for administrative purposes.
Severe Hemolysis with Negative Direct Antiglobulin Test: A Case Report
Authors: Behzadifard Mahin , Arianezhad Ali , Bandehzadeh Ali , Gholampour Mohammadali
Published: August 2022

A 49-year-old woman with type 2 diabetes mellitus (T2DM) presented to the emergency department. Her examination showed marked pallor, exhaustion, lethargy, yellowish eyes, anorexia, nausea and vomiting.Hematuria; negative standard direct antiglobulin test (DAT); normal glucose 6 phosphate dehydrogenase (G6PD); hemoglobin (Hb), 4.8 g/dl; Mean cell volume (MCV), 91fl; platelet count, 233 × 106 /L; Total bilirubin, 7.0 mg/dl; Glucose, 316 mg/dl; lactate dehydrogenase (LDH), 1750U/L. Undoubtedly, therapeutic panel should have been used for hemolytic anemia. Intravenous (IV) fluids and 2 units of packed cell were transfused. Methylprednisolone with rituximab were started for the patient. After 3 weeks of the patient admission, she was discharged home with stable vital signs and Hb, 10 g/dl. We concluded in the cases that presented along with a severe drop in Hb and evidence of hemolysis which non immune hemolytic anemia is excluded in spite of negative standard DAT limited transfusion besides corticosteroids combined with rituximab, could be helpful in saving the patient.
Study Habits of Secondary Students from A Philippine City Schools Division during Distance Learning
Authors:   College of Education, De La Salle University-Dasmariñas, DBB-B, 4115 West Ave, Dasmariñas, Cavite, Philippines, Salva Royce A. ,   University of the Philippines-Diliman, Quezon City, 1101 Philippines, Cadavedo Lualhati O. ,   College of Education, De La Salle University-Dasmariñas, DBB-B, 4115 West Ave, Dasmariñas, Cavite, Philippines,   Department of Education, City Schools, Division of General Trias City, 9VPH+PJW, Antel Building, Diego Mojica Memorial School, General Trias City, General Trias, Cavite, Philippines,   Cavite State University, Indang Campus, Indang, Cavite, Philippines, Cadavedo Ser Voie O. ,   Vicente P. Villanueva Memorial School, City Schools Division of Dasmariñas, Sampaloc I, City of Dasmarinas, Philippines, Patinga Kristine T. ,   Santiago Integrated National High School, City Schools Division of General Trias, Philippines,   Cavite State University, Silang Campus, J Rizal, Silang, Cavite, Philippines
Published: August 2022

Study habits is presumed to be a promising indicator as regards the scholastic standing and academic success of students. However, with the unforeseen paradigm shifts in the Philippine education system due to COVID-19, millions of Filipino learners are confronted with various school-related concerns. Their established study habits are undoubtedly disrupted, if not yet depleted. This led the researchers to instigate this research and gather the data pertinent to the attainment of its general objective. In total, there were 4,056 secondary students from nine junior and senior high schools who voluntarily participated in the conduct of this study. With the intention of this quantitative research to gauge the degree of study habits of the respondents, and its potential significance of differences when grouped according to an identified set of independent variables, a set of statistical tools were espoused. For the results, the respondents accumulated an overall mean of 4.14 or often, which implies positive academic practice given its frequent recurrence. Hereafter, t-test and ANOVA statistics also declared that their study habits are significantly different when the mean scores are juxtaposed according to sex (p-value = 2.536E-12 < 0.05), socio-economic status (p-value = 0.03 < 0.05), education level (p-value = 0.02 < 0.05), and preferred modality of learning delivery (p-value = 0.02 < 0.05). This infers that the disparities in the study habits of secondary students are exceedingly distinguishable when clustered as per their demographic information and chosen instructional channel—inclined to the rejection of the null hypotheses.
Analysing an Interactive Problem-Solving Task Through the Lens of Double Stimulation
Authors: Romero Margarida , Barma Sylvie
Published: August 2022

Problem-solving activities have been studied from a diversity of epistemological perspectives. In problem-solving activities, the initial tensions of a problematic situation led to a cognitive dissonance between conflicting motives and instruments to reach the activity goal. We analyze problem-solving in the continuation of Sannino and Laitinen’s (2015) approach to the analysis of a decision-forming apparatus. The originality of this study is in consideration of the materialistic nature of double stimulation that appears during the activity of the CreaCube problem-solving task. This activity engages the participant in solving tasks with interactive robotic instruments. To solve a task, the subject is required to build interactive robotic modules into a specific configuration which will cause the artifact to move from an initial position to a predetermined final position. The conflict of stimuli in the CreaCube is strong and observable because of the tangibility of the artifact, which is manipulated by the participant into different configurations with the goal of solving the task. We discuss double stimulation in relation to the artifactual interactive affordances of educational robotics.
Fluctuations and Selection Bias in 5 and 13 TeV p-p Collisions: Where are the jets?
Authors: Trainor Thomas
Published: August 2022

The ALICE collaboration recently reported high-statistics
p_tpt
spectra from 5 TeV and 13 TeV p-p collisions with intent to determine
the role of jets in high-multiplicity collisions. In the present study a
two-component (soft + hard) model (TCM) of hadron production in p-p
collisions is applied to ALICE p_tpt
spectra. As in previous TCM studies of A-B collision systems jet and
nonjet contributions to p_tpt
spectra are accurately separated over the entire
p_tpt
acceptance. The statistical significance of data-model differences is
established leading to insights concerning selection bias and spectrum
model validity.
Logarithmic corrections for jet production at the LHC
Authors: Byrne Emmet
Published: August 2022

Several important processes and analyses at the LHC are sensitive to higher-order perturbative corrections beyond what can currently be calculated at fixed order. One important class of logarithmic corrections are those which appear when the centre-of-mass energy of a QCD collision is much larger than the transverse momenta of the observed jets.
We describe the High Energy Jets (HEJ) framework, which includes the dominant high-energy logarithms to provide all-order predictions for several LHC processes including Higgs, W, or Z boson production in association with jets. We will summarise some recent developments, in particular the first matching of HEJ to a NLO calculation.
Cracking hadron and nuclear collisions open with ropes and string shoving in PYTHIA8
Authors: Chakraborty Smita
Published: August 2022

Enhancement in strangeness yields in heavy-ion collisions is regarded as one of the attributes of the Quark-Gluon Plasma (QGP) along with jet quenching and final-state collectivity. To reproduce these effects in the MC implementation of the Lund string model in Pythia, the inclusion of non-perturbative mechanisms like string shoving and rope hadronization is crucial. In this proceeding, we discuss our latest implementation of these mechanisms and the preliminary results for the strangeness enhancement in high-multiplicity p-p, p-Pb and Xe-Xe. We conclude with remarks on the ongoing development of the model.
Asymptotics of transverse momentum broadening in dense QCD media
Authors: Caucal Paul
Published: August 2022

We study the asymptotic behaviour of the transverse momentum
broadening distribution of an energetic quark or gluon propagating
through dense QCD matter, in the large system size
LL
limit, taking into account radiative corrections in the double
logarithmic approximation. Thanks to a connection between the evolution
of the jet quenching parameter \hat{q}q̂
and the formation of traveling wave fronts in nonlinear physics, we
obtain a formula for the LL
dependence of the characteristic transverse momentum scale
Q_sQs
of the distribution valid up to terms of order
1/\ln(L)1/ln(L).
We briefly discuss the physical implications of this formula for jet
quenching and small-xx
phenomenology.
Netakimab in the therapy of psoriatic onychodystrophy
Authors: Zhukova O. V. , Artemyeva S. I. , Al-Hawatmi A. , Pechatnikova E. A.
Published: August 2022

Psoriatic onychodystrophy affects up to 50% of patients with psoriasis and up to 80% of patients with psoriatic arthritis, with an estimated lifetime risk of nail plate changes in this patient population of up to 90%. Nail psoriasis is characterised by a variety of morphological changes resulting from the inflammation in the nail matrix or nail bed, leading to functional impairment and negative impact on patient’s quality of life. Psoriatic onychodystrophy is a distinct therapeutic problem, as its localization is torpid to the current treatment. The limited penetration of topical agents through the nail plate together with the poor adherence to treatment make them typically ineffective. Systemic therapy is often regarded by dermatologists as inappropriate for patients with limited cutaneous lesions. Many systemic drugs, especially biologics, are effective in treating nail psoriasis, but with delayed and less pronounced effects compared to the improvement of skin manifestations. Efficacy for nail changes should be evaluated after 3–6 months of therapy. Recent studies demonstrate that the best effect is achieved after 1 year of treatment. This article presents the main clinical features of psoriatic onychodystrophy and provides information about the interleukin 17A (IL-17A) inhibitor drug netakimab as a promising therapeutic agent for patients with nail psoriasis. It also describes our own clinical experience of using netakimab in the therapy of patients with psoriasis coupled with onychodystrophy. Our experience of using netakimab in two cases of resistant psoriasis accompanied by nail lesions demonstrates its high efficacy in treatment of patients with both plaque psoriasis and psoriasis with “difficult”, hard-to-treat locations, such as nail plate lesions.
Psychiatric comorbidity and psycho-emotional status of patients with acne
Authors: Dvoriankova E. V. , Shevchenko N. A. , Zhukova O. V.
Published: August 2022

Acne is a very common skin disease that has a significant impact on the psycho-emotional status of patients. This disease affects various areas of patients’ lives, leading to problems in body image, socialization, and sexuality. The change in appearance and the psycho-emotional stress associated with the development of acne can also affect other aspects of  patients’ lives, including educational attainment, social activity, and a decline in academic performance and ability to work. Interpersonal problems in acne patients can occur not only with acquaintances and colleagues, but also within the family. The presence of  a  pronounced cosmetic defect, along with acute psycho-emotional problems, leads to a sharp decrease in quality of life, which is often exacerbated by comorbid psychiatric pathology: anxiety, depression, dysmorphophobia, self-injurious behavior, which certainly requires timely, effective and safe therapy for the underlying skin disease. Isotretinoin is an effective medication for the treatment of severe and treatment-resistant forms of acne. This drug has an  effect on all four pathophysiological factors of acne development. Isotretinoin reduces sebum production, regulates hyperkeratosis in the estuaries of sebaceous follicles, reduces the number of Propionibacterium acnes on the skin and is thought to have certain immunological and  anti-inflammatory effects. This is why the introduction of this drug into clinical practice has been recognized as an incredible triumph in the treatment of vulgar acne. However, the presence of  some undesirable side effects may limit its widespread use. In 1982, for example, the FDA issued a warning about the possible risk of depression and the occurrence of suicidal thoughts and attempts while using isotretinoin. However, this warning was not subsequently confirmed.
Polycomponent drugs in the treatment of intertriginous dermatosis
Authors: Kovaleva Yu. S. , Kokina O. A.
Published: August 2022

The most common localization of dermatoses of combined etiology are intertriginous areas. In recent years, an increase in the number of patients suffering from dermatoses of combined etiology has been recorded. The reasons for this situation can be both irrational therapy and background comorbidities in the patient, as well as a number of anatomical and physiological prerequisites for the formation and maintenance of an inflammatory infectious process with localization, namely in the area of skin folds. The article describes in detail the anatomical and physiological features of these areas, the causes of the development of dermatosis of the combined etiology of the fold area. Epidemiological and statistical data on the distribution of a combination of acute, chronic, infectious and non-infectious dermatoses, the causes and frequency of their occurrence are given. Particular attention is paid to the microbiocenosis of the skin in various dermatoses with an emphasis on intertriginous localizations. Approaches to the treatment of such conditions involve the use of combined external agents containing topical corticosteroids, antimicrobial and antifungal components. The article presents data available in the literature on the effectiveness of the use of a multicomponent preparation – Tetraderm cream (consisting of an antibiotic-aminoglycoside + tissue repair stimulant + GCS for local use + an antifungal agent – econazole nitrate) for various dermatoses localized in intertriginous areas. We present our own clinical observations of the effectiveness of the use of this polycomponent preparation Tetraderm in the treatment of patients with skin lesions of combined etiology in the area of folds in atopic dermatitis, allergic dermatitis, mycotic, staphylo-streptococcal infections occurring in combination.
Bacteriophages in the treatment and prevention of atopic dermatitis and dermatoses complicated by secondary bacterial infection
Authors: Zhukova O. V. , Kasikhina E. I. , Ostretsova M. N. , Nemer A.A.M.
Published: August 2022

Bacteriophages are a large group of viruses that can selectively affect bacteria. Bacteriophages and their ability to regulate the growth and activity of pathogenic microorganisms were discovered by scientists at the beginning of the 20th century. Further studies of the properties of bacteriophages led to the construction of the modern concept of virus activity and formed the ground of molecular genetics and biology. To date, more than 6 000 phage species are known to be ubiquitous, but a prerequisite for their existence is the presence of a bacterial host cell, proteins and energy resources serve as the basis for further viral replication. The ability of bacteriophages to selectively destroy bacterial host cells is of particular importance for the therapy and prevention of dermatoses with a potential risk of bacterial infection or pathogenetically aggravated by the activity of the bacterial flora. Such dermatoses include atopic dermatitis, acne, eczema, psoriasis, pyoderma. The article highlights the main advantages and features of bacteriophages, presents data from some of the currently available studies on the use of phages in dermatovenereology. To illustrate the possibility of using bacteriophages in dermatology, a clinical case of successful relief of exacerbation of IgE- independent atopic dermatitis with a high risk of secondary infection in an 8-year-old child is presented. In this case, as an additional to the recommended standard external anti-inflammatory therapy, a gel for external use was prescribed based on a complex of more than 70 virulent bacteriophages capable of inhibiting the growth of actual bacterial strains, among them Staphylococcus spp. (including S. aureus), Streptococcus spp. (including S. pyogenes), Cutibacterium acnes, etc. The range of bacteriophages in dermatovenereology can be expanded due to the constant growth of antibiotic resistance. The use of bacteriophages in routine dermatological practice requires further clinical trials.
Penafsiran Ṭāhir Ibn ‘Āsyūr Terhadap Ayat-ayat tentang Demokrasi: Kajian atas Tafsir al-Taḥrīr wa al-Tanwīr
Authors: Nikmah Lutfiyatun
Published: August 2022

This study explains Ibn ‘Āsyūr interpretation of the verses about democracy in the Tafsir al-Taḥrīr wa al-Tanwīr with historical approach. Some of the issues explained include democratic relations with Islam, democratic practices in Muslim countries, acceptance of Ibn ‘Āsyūr on the existential principles of democracy namely the principle of freedom, equality, and popular sovereignty. This thesis finds that there is a difference between liberal democracy and Islamic democracy where freedom in Islam is restricted as long as its actions do not harm others. In Islam there is a supreme source that can not be changed by the will of the people ie shari'a law as applied qiṣās. The decision-making is based on quality (opinions that are more directed to the goal) while the technique is not standardized. Relation of state and religion according to Ibn ‘Āsyūr is integrative in terms of rejecting secularization between the two.* * *Penelitian ini menjelaskan penafsiran Ibn ‘Āsyūr tentang ayat-ayat tentang demokrasi dalam tafsir al-Taḥrīr wa al-Tanwīr dengan pendekatan sejarah. Isu yang akan dipaparkan di antaranya hubungan demokrasi dengan Islam, praktek demokrasi di negara muslim, penerimaan Ibn ‘Āsyūr mengenai prinsip-prinsip eksistensial demokrasi yaitu prinsip kebebasan, persamaan, dan kedaulatan rakyat. Tesis ini menemukan bahwa terdapat perbedaan antara demokrasi liberal dan demokrasi Islam dimana kebebasan dalam Islam dibatasi selama tindakannya tidak membahayakan orang lain. Dalam Islam ada sumber tertinggi yang tidak dapat diubah oleh kehendak rakyat yakni hukum syari’at seperti diterapkannya qiṣās. Adapun pengambilan keputusan didasarkan pada kualitas (pendapat yang lebih mengarah kepada tujuan) sedangkan tekniknya tidak dibakukan. Hubungan negara dan agama menurut Ibn ‘Āsyūr adalah integratif dalam artian menolak sekularisasi di antara keduanya.
Interaksi Kaum Sufi dengan Ahli Hadis: Melacak Akar Persinggungan Tasawuf dan Hadis
Authors: Arafat Ahmad Tajuddin
Published: August 2022

This article examines the root of intersection between the study of Sufism and Hadith through the interaction between Sufis with the Hadis Transmitters (Ahl al-Hadis). A historical approach used in this research. The result founded that some early Sufis identified as active and credible transmitters of Hadis. Early Sufis generations already applied the exoteric views or irfani perspective toward understanding the Hadis. This view is a pillar for them to get the significance of the Prophetic traditions. It stated that early Sufis make the Prophet attitude as an ideal model for them. The research also founded that the Sufi’s interactions with the Transmitters are considered as a dialogical interaction between them. These interactions historically confirmed in the middle of the second century of hijriyah, for example, Ibnu Mubarak (118 H.), and the third century of hijriyah,  al-Muhasibi (243 H) and Zun an-Nun al-Misri (245 H).* * *Artikel ini mengkaji akar persinggungan antara kajian Tasawuf dan Hadis melalui pola interaksi para Sufi dengan perawi Hadis (Ahl al-Hadis). Penelitian ini menggunakan pendekatan historis. Hasil penelitian menunjukkan bahwa ada beberapa sufi awal yang diidentifikasi sebagai perawi aktif dan kredibel dari Hadis. Sufi generasi awal sudah menerapkan pandangan eksoteris atau perspektif irfani terhadap pemahaman Hadis. Pandangan ini merupakan hal yang penting bagi mereka untuk mendapatkan hakikat makna hadis Nabi. Sufi awal selalu menjadikan Nabi sebagai model ideal untuk mereka. Gambaran interaksi Sufi dengan perawi dianggap sebagai interaksi dialogis antara keduanya. Interaksi ini secara historis terjadi pada pertengahan abad kedua hijriyah, terutama di zaman Ibnu Mubarak (118 H.), dan pada abad ketiga hijriyah, di era al-Muhasibi (243 H) dan Zun an-Nun al-Misri (245 H).
Al-Fiqh Al-Islāmiy wa Āṡāruhu ‘alā al-Qānūn al-Ūrūbiy
Authors: Meirison M
Published: August 2022

Islamic Jurisprudence and Its Effects on European Law. A must for every Muslim to know and a right to know where someone draws European law and obsessed with him and not to say that Europe is the bearer of progress and prosperity for us and family law (ahwal as-syakhsiyah) as civilization and without it will live in the darkness and the darkness in life. Western nations will easily be said that the Islamic world has been indebted to the west to build their laws, especially in the field of private law (ahwal as-syaikhsiyah), marriage, inheritance and other mu'amalah actual fields formerly derived from Islam itself as joint property ownership in marriage. Even Islamic law has effect until the current international law.* * *Pengaruh Fiqh Islam Terhadap Hukum di Eropa. Sebuah keharusan bagi setiap muslim untuk mengetahui dan berhak untuk tahu di mana seseorang menggambar hukum Eropa dan terobsesi dengannya dan agar tidak mengatakan bahwa Eropa adalah  pembawa kemajuan dan kemakmuran bagi kita dan hukum keluarga (ahwal as-syakhsiyah) sebagai peradaban dan tanpa itu akan hidup dalam kegelapan dan kegelapan dalam kehidupan. Bangsa barat dengan mudah akan mengatakan dunia Islam telah berhutang kepada barat untuk membangun hukum mereka terutama di bidang ahwal as-syaksiyah, pernikahan, waris dan bidang mu'amalah lainnya yang sebenarnya dahulunya berasal dari Islam sendiri seperti kepemilikan harta bersama dalam perkawinan. Bahkan hukum Islam mempunyai pengaruh sampai kepada hukum internasional yang berlaku sekarang.
TAREKAT ASY-SYAHADATAIN: SEJARAH, AKTIFITAS, DAN AJARAN
Authors: Rosyid Moh
Published: August 2022

Tarekat Asy-Syahadatain was established in Panguragan, Cirebon, West Java in 1947. It, then, expanded to Central Java. In most cases, tarekat was established in the Middle East and then spreaded to Nusantara. Asy-Syahadatain was founded by Habib Umar, firstly as a religious congregation (pengajian) which later on developed into a tarekat. The name was taken from its teachings which focused on the implementation of syahadat in daily life. This article employed a library research method. The results are the specificity of this tariqa to recite syahadat, shalawat tunjina, and to wear white clothes during canonical prayers and supplementary prayers. AbstrakTarekat Asy-Syahadatain tumbuh di Panguragan, Cirebon, Jawa Barat tahun 1947 hingga kini berkembang di Jawa Tengah. Lazimnya, tarekat tumbuh di Timur Tengah dan berkembang hingga di Nusantara. Tarekat ini dideklarasikan oleh Habib Umar yang awalnya mendirikan kelompok pengajian syahadatain hingga nama ini diabadikan menjadi nama tarekat. Penamaan syahadatain karena mendalami makna kata syahadat dan diwujudkan dalam perilaku. Penelitian ini, menggunakan metode library research. Hasil dari penelitian didapat bahwa, Kekhasan tarekat ini yaitu mentradisikan membaca syahadatain, membaca salawat tunjina, dan berpakaian serba putih (surban dan sejenisnya) bagi perempuan dan lelaki tatkala salat maktubah dan salat sunah.
ISLAM NUSANTARA: MODERASI ISLAM DI INDONESIA
Authors: Mubarok Ahmad Agis , Rustam Diaz Gandara
Published: August 2022

This paper aims to find out the character of Islam Nusantara, as a manifestation of the existence of moderate Islam that was taught by the Walisongo and religious figures to this day. The historical phenomenology is employed to understand Islam Nusantara. The results of this research showed that Islam in Nusantara has five special characters. First, Islam Nusantara is always in accordance with their contexts. Second, it has a tolerant attitude towards differences. Third, it appreciates traditions that have long existed before. Fourth, it has a progresive attitude towards the progress of time. Fifth, it emancipates. AbstrakTulisan ini bertujuan untuk mengetahui karakter Islam Nusantara,sebagai wujud adanya adanya Islam moderat yang diajarkan oleh para Walisongo dan tokoh-tokoh agama hingga saat ini. Penulis menggunakan pendekatan historis fenomenologis. Hasil penelitian ini menunjukkan bahwa Islam di Nusantara memiliki lima karekter. Pertama, Islam Nusantara selalu sesuai dengan konteks zaman. Kedua, ia mengambil sikap toleran terhadap perbedaan. Ketiga, ia menghargai tradisi yang telah lama ada sebelumnya. Keempat, ia bersikap progresif terhadap kemajuan zaman. Kelima, ia membebaskan.
Diskursus Kelisanan Al-Qur’an: Membuka Ruang Baru
Authors: Alwi HS Muhammad , Hamid Nur
Published: August 2022

This paper is about to discuss discourse as the identity of the Qur'an which is now in the form of writing (Mushaf). In its history, the Qur'an is present in an environment that is familiar with oral traditions, delivered in oral form from the Prophet (speaker) to the Arab community (listeners). Based on the oral delivery, the Al-Qur'an indicates to be examined in the discourse discourse. The result of this paper is the discourse on the oral level of the Qur'an and even the naming as the Qur'an. Until the Qur'an takes the form of a text (mushaf) which is met today by Muslims, but the structure of orality can still be found clearly. With the structure of orality, it certainly presents a specific understanding of orality, as was the revelation understood by the Prophet Muhammad as a speaker and the Arab community as opposed to speech. The occurrence of understanding between the Prophet Muhammad and the Arab Society gives an understanding that the Qur'an contains understanding at that time, so that if there is an inertia, then the Arab community will question the purpose of the verse delivered. From this, the context that is presented in the discourse of oral Qur'an is a clear context, which binds the speaker and listener, or also commonly referred to as contextual.
THE CONTEXTUAL INTERPRETATION OF POLYGAMY VERSES IN THE QUR'AN
Authors: Syarif Fajar
Published: August 2022

This study concluded that polygamy practiced by some Muslims did not have adequate syar'i arguments and were not in accordance with the principles of social justice outlined in the Qur'an. Whereas the arguments that have been used by classical scholars only constitute the justification of the verses of the Qur'an to synchronize classical culture with gender bias. The verses of polygamy in essence contain the rules of justice in treating orphans and not for the legality of polygamy in Islam.
UNIVERSALITAS EKONOMI SYARIAH (PENDEKATAN DIALOG AGAMA)
Authors: Najachah Elysa
Published: August 2022

Economy is an inseparable thing in life. For that we need dialogue skills in various aspects of life related to the economy. The religious dialogue approach is an alternative to solving economic problems. This study uses an interfaith study approach. Islamic economics emerged with rules prohibiting all forms of usury. The prohibition of usury has been put forward by other religions. Religious dialogue regarding the economic view of Sharia has been carried out. The findings of this study are that there is a side of universality obtained from Islamic economics as a solution to economic problems that can be accepted by Islam and non-Islamic religions.
Sufisme Ibnu Arabi dalam Resepsi Aboebakar Atjeh
Authors: Maola Mochammad
Published: August 2022

Ibnu Arabi sebagai filsuf sufi adalah khazanah yang tak habis untuk digali. Sebagai tokoh utama dalam tasawuf falsafi, tidak sedikit ulama klasik atau kontemporer yang menolaknya. Di Indonesia, Ibnu Arabi mendapat banyak tempat, pun penolakan yang tidak sedikit. Aboebakar Atjeh sebagai ulama kontemporer yang berasal dari daerah yang kental keislaman, menulis beberapa tulisan tentang Tasawuf. Dua di antaranya secara khusus membahas Ibnu Arabi. Makalah ini membahas Ibnu Arabi dalam konstruksi Aboebakar Atjeh. Dari makalah ini dapat disimpulkan bahwa Aboebakar Atjeh mendukung pemikiran Ibnu Arabi akan tetapi beliau menulis beberapa hal kontradiktif tentang Ibnu Arabi terkait madzhab akidah antara Bathiniyah, Jabbariyah, atau Asy’ariyah. Selain itu Atjeh juga kurang bisa memahami fenomena ekstase spiritual Ibnu Arabi ketika menulis kitab Tarjuman al-Asywaq. Pembelaan Atjeh terhadap Ibnu Arabi dinilai kental subjektifitas dan kurang kritis.
Arab Spring and The Emergence of Anti-Shia Movement in Indonesia
Authors: Maola Mochammad
Published: August 2022

The rejection of Shia movement in Indonesia is a new discourse. Shia presence in Indonesia has been since the early arrival of Islam. But why the Shia resistance movement emerging in the early 21st century? I argue that the Arab spring is the biggest trigger is related to the rise of anti-Shia movements in Indonesia. This paper will explore the relationship between the Arab spring and its influence on the anti-Shia in Indonesia, including the emergence of a national-level organization called ANNAS, or Aliansi Nasional Anti Syiah (Anti-Shia National Alliance), which was declared on August 20, 2014. It aims to increase public awareness to the issue of anti-Shia and avoid potential conflicts which cause separations and threaten national stability as happened in the Arab countries that are currently happening provocations by parties who have interests and hidden agendas on them. Indonesia as a country that refer to Pancasila should be prepared for the issues that triggered the disintegration of the nation.
Wanita dalam Islam
Authors: Mubarokah Lulu
Published: August 2022

AbstractsIn Islam, there are preferences that said Islam has discriminated between women and man, which is it is gives a loss from woman. But in fact, they who don’t even know about the truth are judging how Islam treating their woman. They gives a negative assume without knowing the reason and the advantages from the Islam law. In fact, most of the Muslim are feels comfortable and keep their activities like usual, without any worries and bridle from the law that have made.AbstrakDalam Islam, pandangan mengenai adanya dikriminasi terhadap perbedaan antara wanita dan pria dianggap sangatlah merugikan para wanita. Padahal, mereka yang tidak mengetahui jelas suatu hukum hanyalah memberikan asumsi negatif terhadap bagaimana Islam memerlakukan para kaum muslimah tanpa mengetahui sebab dan keuntungan dari hukum yang telah dibuat. Pada kenyataanya, banyak dari kaum muslimah sendiri merasa nyaman dan tetap menjalani kehidupannya seperti biasa, tanpa adanya kekangan dari hukum yang telah dibuat.
RESEPSI AL-QUR’AN TENTANG JAMINAN RIZKI SETELAH MENIKAH PADA JAMAAH MAJELIS TAKLIM DAN DZIKIR AL-MUFLIHIN
Authors: Abidin Achmad Azis , Ariyanto Nurul
Published: August 2022

This article analyzed the understanding of the group of Majelis Taklim and Dzikir al-Muflihin in Cepu Village, Cepu Subdistric, Blora Distric toward the holy Qur’an verses wich explains about the guarantee of sustenance after wedding. It used a field research paradigm with the Living Qur’an thematically approach that focuses on the holy Qur’an verses about the guarantee of sustenance after wedding. Data acquisition was done in two ways, by observation and interview. The conclusion was that the group of Majelis Taklim and Dzikir al-Muflihin understood that the guarantee of sustenance referred in the holy Qur’an verses includes: pleasure of the heart; the ability to strive; steady work, unexpected sustenance; and pious descendants.
TIPOLOGI PENERIMAAN TRANSGENDER DI DALAM KELUARGA (STUDI DI PONDOK PESANTREN WARIA AL FATAH DAN YAYASAN WARIA CRISIS CENTER YOGYAKARTA)
Authors: Khafsoh Nur Afni , Bintang Inggriana Sahara , Rilana Gibran Zahra Abida , Khoirunnisa Mila , Sari Rita Dwi Purnama , Pratiwi Ozzy Mahar , Shidiq Andris Fathu Rahman
Published: August 2022

Transgender is often one of the groups who are vulnerable to living unfit. This is due to its limitations in accessing various things such as education and employment. In addition, their families often don't accept them, even though the family is the strongest fortress in protecting transgender people from violence and oppression. This study looks at how the acceptance of transgender families in the family and identifies the typology of families in accepting transgender family members. This research is qualitative research with data collection techniques and in-depth interviews. The research location was at the Al Fatah Transgender Islamic Boarding Home and the Waria Crisis Center Community in Yogyakarta.The result of this study is that the existence of transgender people is still considered a disgrace to the family so that evictions still occur. The family form is like doing Rukyah, forced marriage. So, many transgender people end up leaving their families. In addition, the typology of families who accept the existence of transgender people can be seen from three factors: education, economy, and religious understanding. Thus, family acceptance is very important in transgender life.
The analysis of differences at Binary Image in COVID-19 and ARDS Patients from chest X-Ray examination
Authors: Anggraeni Syntia , Nuryani Siska , Sumarti Heni , Gideon Samuel
Published: August 2022

Corona virus disease 2019 (COVID-19), a viral infection that was discovered at the end of December 2019 in Wuhan, China. The spread and transmission of this virus is very fast even to all countries in the world. Meanwhile, Acute Respiratory Distress Syndrome (ARDS) is an emergency condition in the field of pulmonology that occurs due to fluid accumulation in the alveoli causes gas exchange disorders so that oxygen distribution to tissues were reduced. In this study, Chest X-Ray (CXR) image processing done in COVID-19 and ARDS patients with the aim of analyzing the differences in binary image using the Otsu Thresholding method. This study prioritizes improving the quality of the original CXR image by segmentation using calculating the Peak Signal-to-Noise Ratio (PSNR) and Mean Square Error (MSE) values. The results showed that the difference between CXR images in COVID-19 patients and ARDS lies in the extent of spread, in COVID-19 patients the extent of spread varies depending on the length of time the virus has invaded and not all of it starts from the alveolus, while ARDS tends to be constant and starts from the lungs. The lower part of the lung, specifically the alveoli. ©2022 JNSMR UIN Walisongo. All rights reserved.
Treatment of heavy metals contaminated water: use of B. mojavensis BI2 derived lipopeptide and palm waste flour
Authors: Inès Mnif , Mekki Salwa , Ghribi Dhouha
Published: August 2022

In the present work, we demonstrated the potential use of newly identified lipopeptides produced by B. mojavensis BI2 along with palm waste flour for the bioremediation of heavy metals contaminated water. The enhancement of radish seeds germination was used to evaluate the treatment efficiency. Firstly, better enhancement in the order of 3.8, 2.52, 1.5 and 5 were recorded respectively for 200 mg/L copper, lead, cobalt and mercury with respective lipopeptide quantities of the order of 200, 300, 200 and 400 mg/L. When studying the sequestration of increasing heavy metals concentration, BI2 lipopeptide was effective. Secondly, a mixed bioprocess was evaluated using palm waste flour as heavy metals sequester and BI2 lipopeptides as improver. Optimal biosorption of lead, copper, cobalt and mercury were obtained with 10 g/l waste, 1,000 mg/l metal and 200 mg/l BI2 lipopeptide for 1 hour. The addition of 200 mg/l BI2 lipopeptide improves the efficiency of the treatment significantly.
Fabrication of lanthanum/chitosan co-modified bentonite and phosphorus removal mechanism from low-concentration landscape water
Authors: Fu Chengbin , Li Ye , Zuo Yangyang , Li Bolin , Liu Chang , Liu Dongxue , Fu Yan , Yin Yixin
Published: August 2022

It is essential to solve the problem of phosphorus pollution in urban landscape water and reduce the degree of eutrophication. In this paper, lanthanum-modified bentonite (La-B) was prepared by high-temperature calcination and liquid-phase precipitation. Then La-B was modified with chitosan to prepare a low-cost environment-friendly functional material: lanthanum/chitosan co-modified bentonite (La-BC). It can reach the adsorption equilibrium within 30 min, and the maximum adsorption capacity is 15.5 mg/g (initial phosphate concentration 50 mg/L); when the target concentration is 2 mg/L, the removal rate can reach 98.5%. La-BC has a stronger anti-interference ability to common coexisting anions SO42−, HCO3−, NO3− and Cl− in the urban landscape water body. La-BC has excellent performance in weakly acidic to neutral water, and its pH applicable range has been improved, making it possible to apply in practical water. The fitting results show that the adsorption behavior conforms to the pseudo-second-order kinetic model and the Freundlich model. After 5 regenerations, the removal efficiency remained around 80%. In the actual water test results, the phosphate concentration can be controlled below 0.1 mg/L and the removal rate is above 75%. Due to its low cost and reusability, it has great potential in the practical application of phosphate removal from landscape water.
Targeted Nanotherapies for the Posterior Segment of the Eye: An
Integrative Review on Recent Advancements and Challenges
Authors: Gogoi Niva Rani , Marbaniang Daphisha , Pal Paulami , Ray Subhabrata , Mazumder Bhaskar
Published: August 2022

The eye is a one-of-a-kind sensory organ with intricate anatomy and physiology. It is
protected by a variety of barriers, ranging from static barriers to dynamic barriers. Although these
barriers are very effective at protecting the eye from exogenous substances and external stress,
they are highly compromised by various vision-impairing diseases of both the anterior and the
posterior segment of the eye. Due to ocular elimination systems and intricate obstacles that selectively
limit drug entry into the eye, effective drug delivery to the posterior segment of the eye
(PSE) continues to be a challenge in ophthalmology. Since more than half of the most debilitating
eye illnesses are thought to originate in the posterior segment (PS), understanding the physiology
and clearance mechanism of the eye could help design improved formulations that could be noninvasive
and intended for targeted posterior segment therapeutics. Moreover, the major drawback
associated with the conventional drug delivery system to PSE is minimal therapeutic drug concentration
in the desired ocular tissue and life-threatening ophthalmic complications. One possible
approach that can be implemented to overcome these ocular barriers for efficient ocular therapy,
non-invasive and targeted drug action to the posterior tissues is by designing nanomedicines. This
review summarizes the recent non-invasive and patient compliant advances in designing nanomedicines
targeting PSE. The various routes and pathways of drug administration to the ocular tissue
are also summarized.
Role of Reactive Oxygen Species in Neurodegenerative Diseases
Authors: Tripathy Sukanya , Singh Sanjay , Banerjee Monisha , Prakash Anand
Published: August 2022

The altered redox state leads to oxidative stress through the extravagant
synthesis of reactive oxygen species (ROS) and inhibition of the antioxidant system.
The high oxygen demand in nervous tissue makes it vulnerable to ROS, and the
presence of peroxidation-prone lipid cells worsens the situation. We now understand
that oxidative stress plays a role in the pathophysiology of neurodegenerative diseases
such as Parkinson's disease, Motor neuron disease, and Alzheimer's disease. In spite of
the fact that there is no lasting cure for any of these diseases, antioxidant treatments
have been promoted as ways to treat and discourse neurodegenerative diseases.
However, the results regarding their efficacy are contradictory. This chapter examines
the role played by oxidative stress in the etiology of neurodegenerative diseases and
how they lead to brain dysfunction in people. It will later provide an overview of
antioxidants as a therapeutic option for oxidative stress-induced damage.