bluuebunny/crossref_metadata_2025 huggingface dataset:
COMPARATIVE STUDY BETWEEN THE EFFICACY OF CONVENTIONAL PLAIN VICRYL AND ANTIBACTERIAL VICRYL CONTAINING TRICLOSAN
Authors: Sudarsan P.K Sri , Lata Jeevan , Kajla Paramjit , Sooch S.P.S , Prashar Sahil
Published: August 2023

Introduction: Third molar surgeries are the most commonly practiced surgeries in the dental office. The incidence of surgical site infection is still higher in spite of antibiotic prophylaxis owing to the need for the use of alternative measures. Antibacterial sutures are recently being used following third molar surgeries to reduce the incidence of surgical site infections and inflammatory sequels. Objectives: To assess vicryl plus sutures in comparison with conventional plain vicryl in various parameters like swelling, infection, trismus, erythema and pain. Methods: Total of thirty patients having bilateral impacted mandibular third molars were selected. Plain vicryl was used for primary closure after disimpaction on the former side (Group A) and vicryl plus containing triclosan for the same on the contralateral side (Group B). Swelling, trismus, erythema, infection and pain were compared between the groups consecutively on 3rd, 7th, 15th days and one month. The observations and results were compiled. Results: The study yielded significant statistical results in terms of trismus, pain and erythema although the numerical significance was seen in all parameters. Conclusion:Vicryl suture containing triclosan was comparatively more effective in reducing the post-surgical sequel after third molar surgery than conventional plain vicryl suture.
DOCKING STUDIES OF BCL-2 WITH COSMOSTIGMACORDATUMCOMPUNDS FOR ANTI-CANCER STUDIES
Authors:   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Jasthi Sravya , Abburu Tejasri ,   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Sree Thanay Allam Sai ,   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Govind Geya ,   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Ravula Nandini ,   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Tripurana Manas ,   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Singh Ranwas Reethika ,   Department of Molecular Biology, Cresent Biosciences, ICRAB Campus, Kanpur, Uttar Pradesh, India.
Published: August 2023

Medicinal plants have wide spread properties due to the presence of phytocompounds and are the alternative medicines available for thosewho cannot be helped by conventional medicine. In this work we have selected bioactive compounds from Cosmostigmacordatummedicinal plant extracts. Docked compounds were used for anti-cancer activity by insilico method with BCL-2 which plays prominent role in causing cancer. Out of twentyselected compounds, docking results showedMethyl-1-Cyclo Hexane carboxylate and1,2-diacetoxy-5-idohexane as best docked to the BCL-2.
E-DATABASEINFORMATION OF INDIAN MEDICINAL PLANTS AND ITS ACTIVE INGREDIENTS
Authors:   Department of Biotechnology, School of Sciences, PPSavaniUniversity, Surat, Gujrat, India., Kumar Ashutosh , Wany Aakanksha ,   Department of Biotechnology, School of Sciences, PPSavaniUniversity, Surat, Gujrat, India., Kumar Jha Rajesh ,   Department of Biotechnology, School of Sciences, PPSavaniUniversity, Surat, Gujrat, India., Kumar Singh Pratik ,   Department of Biotechnology, School of Sciences, PPSavaniUniversity, Surat, Gujrat, India.
Published: August 2023

India is a land of indigenous medicinal plants and diverse wildlife. Since ancient time, Indians are usingthese plants and their extracts as medicine for the treatment of human diseases, and termed as traditional medicine (TM). Ayurveda, an alternative TM system, is well known across the Indian subcontinent. The oldest manuscript on Ayurveda practice is SushrutaSamhitabySushruta,written in 6th century BCE. It emphasises the use of medicinal plants and its parts with healing properties for health practices. The phytochemicals of a medicinal plant encompasses essential oils, flavonoids, saponins, steroids, phenylpropanoids and waxes. These phytochemicals are synthesized by plants as secondary metabolites, but, have numerous industrial applications. Though, we have these ancient medical practicing systems, but their documentation, dosage, inhibitory concentrations, where-abouts and the origin of medicinal plants is still not up to date. Therefore, there is a need for a repository where all the information regarding the medicinal plants and its properties should be listed. Here, we are discussing all the comprehensive information regarding all these databases of indigenous medicinal plants, which will apprehend our knowledge and understanding about Indias vast diverse medicinal flora.
USING BLOCKCHAIN TECHNOLOGY FOR FORENSIC ENGINEERING OF DIGITAL ASSET BUSINESS IN THAILAND
Authors:   Ph.D. Student in Engineering Law and Inspection, Ramkhamhaeng University, Bangkok Thailand., Sawetthapong Dhivaravet , Kongsong Waranon ,   Assistant Professor, Department of Engineering, Ramkhamhaeng University, Bangkok, Thailand., Kongbenjapuch Kijbodee ,   Special Professor, Department of Public Law, Ramkhamhaeng University, Bangkok, Thailand., Tuprakay Seree ,   Associate Professor, Department of Engineering, Ramkhamhaeng University, Bangkok, Thailand., Srithammasak Boonchuay ,   Lecturer, Department of Engineering, Ramkhamhaeng University, Bangkok, Thailand., Roykulcharoen Sumeth ,   Vise President of the Supreme Administrative Court, Department of Supreme Administrative Court, Administrative Court, Bangkok, Thailand.
Published: August 2023

This research article aims to study the use of blockchain technology for forensic engineering in Thai digital asset business. This research uses qualitative research methods based on in-depth interviews with experts related to blockchain technology. Digital asset business and engineering verification is a study based on the digital forensic process model. According to the international standard ISO/IEC 27037 , it consists of 4 components: 1) evidence identification 2) data collection 3) data acquisition 4) integrity of evidence. The study found that the use of blockchain technology increases the efficiency of the digital forensics process, solves problems in the original system andmakes the information and the evidence to be accurate and reliable. Blockchain technology also increases the security of information as Information security management system standards(ISMS) or ISO 27001 has completed all 3 elements: confidentiality, integrity and readiness for use.
COMPARISON OF FOAM SCLEROTHERAPY AUGMENTED PHLEBECTOMY VERSUS AMBULATORY PHLEBECTOMY IN THE MANAGEMENT OF ISOLATED BELOW KNEE INCOMPETENT PERFORATORS
Authors: V.P Balaji , Raj G. Preetham , I. Guttedar Karthik , K. Saravanan , S.K Ramesh
Published: August 2023

Background & Objectives:Among the patients who underwent Foam Sclerotherapy Augmented Phlebectomy (FSAP) and Ambulatory Phlebectomy (AP) a) To determine the number(proportion) patient seeking for post operative pain (greater than 3 according to visual analog scale in 1 months of procedure) b) To determine median number of days to resume normal activities c) To assess the healing of venous ulcer using CEAP classification and revised venous clinical severity scoring system. d) To identify any recurrence at the same site of Earlier Phlebectomy (FSAP or AP) using duplex scan after 6 months of procedure Methods: Patients satisfying inclusion criteria are enrolled within 24 hrs of admission afterinformed consent. All the patients with isolated below knee perforator incompetence will be evaluated with through clinical examination, radiological and laboratory investigations. Those who require surgery will be admitted and appropriate surgery will be performed and analyzed for in term of post operative pain, operative time, hospital stay, number of days to resume normal activities, healing of venous ulcer, recurrence. Results: Majority of patients belonged to the age group 41- 50 years. M: F is66% males and 34% females. number of days to resume normal activities by the patient mean days among FASP group 9.4% and AP group is 12.8%Post Procedure VAS pain score in 1 month among study participants mean vas score among Foam Sclerotherapy Augmented Phlebectomy 4.5% and Ambulatory Phlebectomy 5.1%length of hospital study in FSAP group mean 5.1% and in AP group 5.3%, Recurrence among the patients underwent FSAP group 4.7% and in AP group 14.5%. Interpretation & Conclusion:FSAP is associated with less post operative pain, shorter duration pf hospital stays and a quicker recovery, shorter duration of surgery, earlier return to work and not associated with major postoperative complications. There is less recurrence in FSAP compared with AP in the follow up period of six months.
Antecedents of organizational citizenship behavior of marketing and supply chain employees
Authors: Josua Sembiring Murpin , Eliyana Anis , Papian Marcelia , Arief Zainal , Yazid Zaleha
Published: August 2023

A marketing career entails a heavy burden and requires much originality and creativity, which can result in interpersonal friction. This situation influences employees’ affective commitment and organizational citizenship behavior (OCB). Consequently, the purpose of this study is to investigate how affective commitment, work overload, and interpersonal conflict may impact OCB when combined with social interaction. This survey involved 61 personnel from the marketing and supply chain departments of an Indonesian state-owned enterprise. The data were analyzed using a quantitative method and partial least squares (PLS) approach. This study revealed that work overload and interpersonal conflict have a negative impact on positive behavior and actions, including OCB and affective commitment. In addition, the findings accentuate the importance of employees’ affective commitment because it directly encourages employees to take on extra responsibilities. Furthermore, social interaction does not moderate the relationship between work overload and interpersonal conflict on affective commitment. This study broadened perspectives on OCB concerning work-related stressors and provided direction for the managerial team to cope with workload and conflict in the decision-making process.
The Effect of the Portage-Supported Mother Education Program on the Self-Care Development of the Child with Autism
Authors: KILIÇ Kevser , YILDIZ Fatma Ülkü
Published: August 2023

Introduction: Self-care skills are among the basic skills required to support the independent living skills of children diagnosed with Autism Spectrum Disorder (ASD). It was observed that there are a limited number of studies in the literature that include programs used in this context (e.g. Behavioral Intervention Program for Children with Autism, [OÇİDEP]). Thus, it was aimed to overcome this limitation and examine the effect of the "Portage Supported Mother Education Program" on the self-care development of the child with ASD. In line with this purpose, the effects of the program on the behaviours of washing hands with liquid soap, eating with a fork, and wearing a jacket with zipper of the child with ASD were examined, the generalisability and permanence levels of the behaviours were examined, and the mother's opinions were taken.
Method: Inter-behaviour multiple baseline model, one of the single-subject research models, was used. Participants were a 4-year-old 5-month-old boy with ASD and his 38-year-old mother. Dependent variables were washing hands with liquid soap, eating with a fork, and wearing a jacket with zipper. Independent variable was "Portage Supported Mother Education Program".
Findings: The data were analysed and transferred to line graphs. When the findings were examined, it was seen that the program had a positive effect on the behaviours of washing hands with liquid soap, eating with a fork, and wearing a jacket with zipper, the child was able to generalise the behaviours, the effect was permanent and the program was feasible.
Discussion: The findings were discussed within the framework of the literature. Studies similar to the findings of the study were found in the literature. According to the findings, the program is effective, permanent and feasible for the self-care development of children with ASD.
Conclusion and Recommendations: The program was found to be effective for the self-care development of the child with ASD and feasible for the mother. Therefore, it can be recommended to extend this study by studying with more children with ASD and their mothers, and conduct other studies with the participation of the father.
Development of an agent-based model to improve emergency planning for floods and dam failures
Authors: Lumbroso Darren , Davison Mark , Wetton Mark
Published: August 2023

The Life Safety Model (LSM) is an agent-based model which assists with emergency planning and risk assessments for floods and dam failures by providing estimates of fatalities and evacuation times. The LSM represents the interactions of agents (i.e. people, vehicles, and buildings) with the floodwater. The LSM helps to increase the accuracy of estimates of loss of life and evacuation times for these events by taking into account a number of parameters which are not described in empirical models, such as the people's characteristics (e.g. age and gender), building construction types, and the road network. The LSM has been applied to three historic flood-related disasters: the 1953 coastal floods, in the UK; the 1959 Malpasset Dam failure, in France; the 2019 Brumadinho tailings dam disaster, in Brazil. These illustrate how the LSM has been verified and improvements to evacuation routes, early warnings, and the refuge locations could have reduced the number of fatalities. The value of using the LSM is not to calculate the ‘exact’ number of flood deaths or evacuation times, but to assess if emergency management interventions can significantly reduce them. The LSM can also be used to assess whether the societal risk posed by dams and flood defences is ‘acceptable’.
Percepção dos residentes multiprofissionais acerca da espiritualidade no processo de sedação paliativa oncológica
Authors: Frederico Conceicao Grazielle Teixeira , Silva Rose Mary Costa Rosa Andrade , Pereira Eliane Ramos , Bulnes Amélia Marina Morillas , Ramirez Esther Justina , Carneiro Eliane Cristina Pinto
Published: August 2023

Objetivos: Identificar a percepção dos residentes multiprofissionais acerca da espiritualidade no processo de sedação paliativa oncológica. Método: Estudo qualitativo, descritivo e exploratório com referencial teórico na fenomenologia de Maurice Merleau-Ponty, realizado no setor de internação de um centro de referência nacional em tratamento oncológico no Rio de Janeiro/Brasil. Para a coleta de dados utilizou-se a entrevista semiestruturada e fenomenológica, no período de agosto a outubro de 2022. A amostra, composta por 20 residentes, foi por conveniência e realizada pelos critérios de saturação e redundância dos dados. Resultado: Após a análise ancorada no referencial metodológico de Amedeo Giorge, emergiram quatro categorias, sendo uma delas “A comparência da espiritualidade no processo de sedação paliativa”, tendo como subcategorias: A suspicácia do fenecimento; Adoecimento familiar e; Compaixão na sedação paliativa. Conclusão e implicações na prática: Observa-se a necessidade de profissionais enfermeiros e demais categorias interdisciplinares atuantes em cuidados paliativos buscar apoio para o enfrentamento de suas atividades laborais, assim como a importância e necessidade de maior atenção à formação profissional em saúde, bem como às práticas clínicas no campo da espiritualidade.
Palavras-chave: Sedação Consciente; Percepção; Capacitação de Recursos Humanos em Saúde; Oncologia.
SULF1 Activates the VEGFR2/PI3K/AKT Pathway to Promote the
Development of Cervical Cancer
Authors: Li Juan , Wang Xihao , Li Zhilong , Li Minzhen , Zheng Xuelian , Zheng Danxi , Wang Yanyun , Xi Mingrong
Published: August 2023

Background and Purpose:

Sulfatase 1 (SULF1) can regulate the binding of numerous
signaling molecules by removing 6-O-sulfate from heparan sulfate proteoglycans (HSPGs) to affect
numerous physiological and pathological processes. Our research aimed to investigate the effect
of the SULF1-mediated VEGFR2/PI3K/AKT signaling pathway on tumorigenesis and development
of cervical cancer (CC).

Methods:

The expression and prognostic values of SULF1 in patients with CC were analyzed
through bioinformatics analysis, qRT-PCR, immunohistochemistry, and western blot. The function
and regulatory mechanism of SULF1 in proliferation, migration, and invasion of cervical cancer
cells were examined through lentivirus transduction, CCK8, flow cytometry analysis, plate colony
formation assay, scratch assay, transwell assay, western blot, VEGFR2 inhibitor (Ki8751), and
mouse models.

Results:

SULF1 expression was significantly upregulated in CC tissues, which was significantly associated
with poor prognosis of patients with CC. In vitro, the upregulation of SULF1 expression
in HeLa cells promoted cell proliferation, colony formation, migration, and invasion while inhibiting
apoptosis. Conversely, the downregulation of SULF1 expression had the opposite effect. In
vivo, the upregulation of SULF1 expression resulted in a significant increase in both tumor growth
and angiogenesis, while its downregulation had the opposite effect. Furthermore, western blot detection
and cell function rescue assay confirmed that the upregulation of SULF1 in HeLa cells promoted
the tumorigenic behaviors of cancer cells by activating the VEGFR2/PI3K/AKT signaling
pathway.

Conclusion:

SULF1 plays an oncogenic role in the tumorigenesis and development of CC, indicating
its potential as a novel molecular target for gene-targeted therapy in patients with CC.
Diagnostic Value of 3D Optical Coherence Tomography Multimode Images in
the Diagnosis of Acute Central Serous Chorioretinopathy
Authors: Zhao Gui-ling , Li Rui-zhuang , Pang Yan-hua , Wang Xiu-qin , Wei Jin-fen , Zhou Zhou
Published: August 2023

Background:

Spectral-Domain Optical Coherence Tomography (SD-OCT) provides non-invasive, high-speed, high-resolution, three-dimensional cross-section imaging of the macula.

Objectives:

This study aimed to investigate the diagnostic value of the multimodal imaging technique of three-dimension (3D) optical coherence tomography (OCT) (3D-OCT) for the diagnosis and characterization of acute central serous chorioretinopathy (CSC).

Methods:

In this prospective clinical study 3D-OCT examinations of 82 cases with acute CSC were performed on the macular area, and the image characteristics were analyzed. Our study included a total of 87 eyes from 82 cases of CSC patients, 67 males and 15 females (mean age ± standard deviation (SD): 42.89 ±7.80 years old; age range: 27 to 56 years old. The 3D-OCT images were evaluated for the presence of subretinal fluid, subretinal space, fluctuation of the internal limiting membrane (ILM), folds of retinal pigment epithelial (RPE), retinal pigment epithelium detachment (PED), and flat irregular PED. The foveal thickness was measured using the manual caliper of OCT software.

Results:

The OCT B-scan images showed 87 (100%) eyes had exudative retinal detachment (ERD), 38 (44%) had flat irregular PED, 36 (41%) had PED, 8 (9%) had subretinal turbidity structure, 2 (2%) had subretinal dot-like precipitates, 1 (1%) had focal choroidal excavation (FCE), and 1 (1%) eye had fluctuation of internal limiting membrane (FI). In the ILM-RPE thickness map, all eyes had a round or round like regular uniform domes. Fifty-seven (66%) domes were limited in the examination area and 30 (44%) domes were beyond the scope of this examination and only a partial section of the dome could be observed. In the en-face image, all eyes had a round or round-like black figure that corresponded with domes in the ILM-RPE thickness map. In RPE surface, 76 (87%) eyes had a shallow plate depression, 71(82%) had small focal uplift, and 1 (1%) eye had a focal concave feature.

Conclusions:

In the OCT ILM-RPE thickness, en-face image, and RPE surface maps, acute CSC exhibited specific imaging characteristics that can be helpful for reliable diagnosis and differential diagnosis of CSC.
Intranasal Delivery of Lipid Nanoparticles: A Ground-breaking Approach
for Brain Targeting
Authors: Jena Devashish , Srivastava Nimisha , Yasir Mohd , Dan Deblina
Published: August 2023

In the present scenario, various novel delivery systems are available for drug delivery to
systemic circulation. So, to accomplish a greater therapeutic effect, the nature of the drug delivery is
very important. This delivery is one of the innovative approaches where the drug is targeted to the
brain through the nasal cavity. As we know, the human brain is the most crucial part of the body that
controls various functions of our system. So, safely reaching the targeted site of the brain is necessary
to achieve brain specificity. This delivery system helps us to tackle the problems that may arise in the
other delivery system and helps the drug reach the brain without any difficulties. The major obstacles
we faced during this delivery were the blood-brain barrier (BBB) and the brain-cerebrospinal fluid
barrier. So, if we target the drug to the brain, then we have to overcome these challenges, and before
that, we must have a clear understanding of the targeted site and the mechanism behind the drug targeting. Advancements in science and technology have helped discover many recent strategies and
formulations available for intranasal delivery. The development of lipid nanoparticles is one of the
primitive approaches for targeting any type of drug(hydrophilic/lipophilic) in the brain. So, the aim of
this review mainly focused on the mechanism of intranasal delivery, the devices used, and some recent
strategies like the development of lipid nanoparticles, surface-modified lipid nanocarriers, and noseto-brain patches. This review article also includes a few FDA-approved formulations for nose-to-brain
delivery and their regulatory aspects related to clinical trials and future perspectives.
System Analysis and Mathematical Modeling of Infection Safety Human Caused by COVID-19 Coronavirus Strains
Authors: Kostarev S. N. , Fayzrakhmanov R. A. , Tatarnikova N. А. , Novikova O. V. , Sereda T. G.
Published: August 2023

The purpose of research is to develop models characterizing the "Cell–Virus–Habitat" system.

   Methods. The ability of coronaviruses to exit the cell without its apoptosis is an important factor providing the possibility of moderate infection. A description of the complete 2019-nCoV gene can be found in the GenBank Virus Genome bank: MN908947.3. Currently, information about the epidemiology, clinical features, prevention and treatment of this disease is being studied by scientists all over the world. Theoretical approaches in the study were based on the theory of virology, system analysis, differential integral calculus and probability theory. The materials were immunogram indicators for the period 2020-2021. According to studies of the effect of coronavirus infection on residents of the Perm Region. Data on the activity of the coronavirus and the number of sick residents were taken from open sources. Data on the number of residents living in the Perm Region were taken from the population census. The structure of the SARS-CoV-2 genome is reflected in the GenBank data-base: MN908947.3. The SARS-CoV-2 mutation tracker was studied by the repository: https://users.math.msu.edu/users/weig/SARS-CoV-2 Mutation Tracker.html .

   Results: the "Cell–Virus–Habitat" model was developed and investigated; a system of differential empirical equations characterizing changes in immunogram parameters among underage and child-aged residents of the Perm Region was constructed and investigated; a system of Kolmogorov equations describing the dynamics of the pandemic in the Perm Region was constructed and investigated.

   Conclusion. One of the consequences of a new coronavirus infection may be a change in the immune system of the human population. A detailed analysis of the immunological status of various racial groups, different ages and gender characteristics under the influence of a new coronavirus infection is currently poorly understood.
Study the effect of olive leaf extract and mango peel extract in treating diabetic disease in mice
Authors: Ali Hasan M.M. Rajaa
Published: August 2023

The current study aimed to determine the effect of olive leaf extract and mango peel extract on diabetic mice. Diabetes was created in the mice by injecting intravenously alloxan 100 mg/kg. The experimental mice were divided into four groups, where the first group was considered normal controls, while the second group was diabetic control. The third group represents the diabetic group treatment with olive leaf extract 100 mg/kg B.w i.p 5 days and the four groups diabetic group treatment with mango peel extract 100 mg /kg .B.w i.p 5 days. According to the biochemical observations, the levels of serum glucose, there was a significant decrease in serum glucose of the diabetic group under treatment with olive leaf extract lower than blood glucose level for diabetic mice treated with mango peel extract compared with the control group herbal treatment olive leaf extract to diabetic mice helps maintain normal sugar level in the blood.

Keywords:- olive leaf, mango peel, diabetic disease.
Prenatal screening and diagnosis teaching mode using clinical laboratory diagnostic pathway in laboratory medicine (Preprint)
Authors: Qiao Bin , Wang Jingwei , Ye Qing , Wu Qian , Gu Jian , Xu Wanzhou , Bao Anyu , Zheng Hongyun , Tong Yongqing
Published: August 2023

BACKGROUND

Conventional prenatal screening and diagnosis only included serological screening, NIPT (Non-Invasive Prenatal Testing) and amniotic fluid chromosomal karyotype analysis, which cannot meet the needs of eugenics.

OBJECTIVE

In this study, a novel prenatal screening and diagnosis laboratory testing strategy is established to improve teaching efficiency and enhance the effects of talent cultivation in laboratory medicine.

METHODS

The guidelines and expert consensuses of prenatal screening and diagnosis were gathered from the professional website of prenatal screening and diagnosis and databases. The clinical laboratory detection strategies were formulated to establish the clinical laboratory diagnostic pathway according to different stages of prenatal screening and diagnosis. The questionnaire, mutual evaluation and paper examination were used to evaluate the teaching effectiveness before and after the teaching of the clinical laboratory diagnostic pathway of prenatal screening and diagnosis.

RESULTS

The prenatal screening and diagnosis clinical laboratory diagnostic pathway was established and approved by clinicians, which included the serological screening, ultrasound screening, carrier screening and direct prenatal diagnosis. The questionnaire results showed that more improvement and significant improvement percentage were significant increased (P < 0.01) and the no improvement and light improvement percentage were significant decreased (P < 0.01) after using the teaching mode of prenatal screening and diagnosis clinical laboratory diagnostic pathway. The mutual evaluation between teachers and trainees showed the contents were significantly improved including points highlighted, accuracy of answering questions, stimulating learning interest and initiative, et al. after the teaching of prenatal screening and diagnosis clinical laboratory diagnostic pathway (P < 0.05). The paper examination of trainees also expressed higher scores after the teaching of prenatal screening and diagnosis clinical laboratory diagnostic pathway (P < 0.05).

CONCLUSIONS

It is necessary to establish the diseases clinical laboratory diagnostic pathway for a novel teaching mode to improve the teaching quality in laboratory medicine, which may increase the confidence of teachers and trainees and enrich their knowledge.
New Forms of alphag - continuous Maps in Topology
Authors: Bhavikatti Kantappa M.
Published: August 2023

Abstract: In this paper, we describe a novel class of continuous maps called as strongly alpha generalised continuous maps in topological spaces. Furthermore, we investigate their properties with existing continuous maps, and we also study their decomposition of continuous functions.
Analysis of Energy Consumption and Carbon Emissions in Indonesia
Authors: Bayu Rahmadi Putra  , Rusgianto Sulistya
Published: August 2023

The development process that uses excessive fossil energy in industrial activities impacts increasing carbon emissions in Indonesia. The purpose of this study is to determine how the relationship between energy consumption (EN), economic growth (GDP), carbon emissions (CO2), and human development (HDI) in Indonesia in the Maqashid Syariah review. Using the Vector Error Correction Model (VECM) approach, it is found that in the long run, carbon emissions negatively affect energy consumption. Meanwhile, economic growth and human development positively affect energy consumption. Energy consumption and economic growth positively affect human development in the short term. Meanwhile, carbon emissions hurt HDI, while HDI has a positive effect on carbon emissions. Meanwhile, the Granger causality test results show that HDI has a unidirectional causality relationship with Indonesia's energy consumption, economic growth, and carbon emissions. This result indicates that energy consumption in Indonesia has not provided protection and benefits for the community by Maqashid Sharia, which prioritizes the principle of sustainable development
Minority shareholder protection and dividend policy: Evidence from the material industry
Authors: Phuong Ta Thu , Hoang Le Duc , Tuan Tran Minh , Van Trinh Mai
Published: August 2023

This study investigates the impact of minority shareholder protection on corporate dividend policy. On one hand, strong minority shareholder protection can be associated with a reduction in dividend payment because shareholders want to receive more dividends to mitigate agency costs. On the other hand, weak minority shareholder protection can lead to an increase in dividend payment since shareholders, in order to protect themselves, may require the company to pay more dividends to compensate for weak minority shareholder protection. Our sample consists of 101 Vietnamese listed firms in the material industry during the period from 2015 to 2021. Employing a pooled ordinary least squares (OLS) model, we find a negative impact of minority shareholder protection on corporate dividend payment. To deal with the endogeneity problem, we apply a system generalized method of moments (GMM) method. The main result estimated from this method is qualitatively unchanged. The finding of this paper suggests that the manager of a company should enhance the corporate governance of the company to protect the minority shareholders.
Personal and Academic Blurred Spaces Hinged on Synchronous Gravities in Nature: Conceptual Musings from Events of (Re-)configurations during COVID-19 Pandemic
Authors: Haris Adhikari
Published: August 2023

This paper inquires into a two-fold issue: (i) blurred personal and academic spaces during the pandemic and their impact, and (ii) nature’s role in them. As a transformative arts-based research (TABR) within an experimental framework deploying concepts of liminality, Derrida’s ‘teleiopoiesis’, and an adapted outlook of experiential interconnectedness or consciousness of Advaita Vedanta, the paper forwards pedagogically useful findings and implications as these: (i) blurred spaces as bizarre or third space entities that were both stressful and productive, (ii) increased exposures to nature and eco-spirituality, followed by heightened realizations of nature’s place in life, learning and being during the pandemic, (iii) heterotopic university as a space or place that effectuated a surge in self-internalization of learning via intense involvement, (iv) compassionate/ empathic living as a door to self-improvement and joy, (v) formations of new habits and routines as coping strategies in the difficult times, and (v) newly formed wholesome habits and synchronous gravities in nature as great contributors to increased reflective or creative productivity during the pandemic. Additionally, yet more importantly, it highlights the instrumentality of human senses as lower rungs in realizing the interconnectedness or consciousness that experiential Advaita proffers, and this it does by communicating the need for individually unique, radically nonlinear, and adventurously inter-/ trans-disciplinary celebrations of the phenomenon. Besides, it celebrates interrelated questions and curiosities throughout.
Predictors of Benzodiazepine Re-Prescription Among U.S. Veterans with a History of Chronic Benzodiazepine Use
Authors: Esmaeili Aryan , Timko Christine , J Katherine Hoggatt , Lewis Eleanor , Macia Kathryn S. , Lor Mai Chee , L Andrea Nevedal
Published: August 2023

Objective: Given difficulty in discontinuing prescribed
benzodiazepines and potential harms to people from chronic
benzodiazepine use, it is important to understand medical and mental
health conditions associated with re-prescription. This study sought to
estimate benzodiazepine re-prescription incidence rates among Veterans
in the United States Veterans Health Administration (VHA) and identify
predictors of re-prescription among Veterans who discontinued
benzodiazepines. Methods: This longitudinal study used VHA
administrative data from patients’ electronic health records in Fiscal
Year 2019. Patients with chronic (>30 days) benzodiazepine
prescriptions who were not prescribed benzodiazepines continuously for
the entire year were identified based on pharmacy records (n=151,777).
We used Kaplan-Meier methods and a Cox proportional hazards model to
estimate benzodiazepine re-prescription incidence rates. Unadjusted and
adjusted hazard ratios were used to examine demographic and clinical
characteristics as predictors of benzodiazepine re-prescription.
Results: Among 151,777 patients who did not refill a
benzodiazepine prescription for ≥30 days, 50% were re-prescribed
benzodiazepines within 2.5 months. Benzodiazepine re-prescription was
associated with mental health conditions (e.g., anxiety, PTSD). Patients
were less likely to be re-prescribed benzodiazepines if they had a
history of an alcohol or drug use disorder, neurological disorder other
than paralysis, chronic heart failure, dementia, and hospice care.
Conclusions: The short gap between benzodiazepine prescriptions
ending and being re-prescribed suggests patients have difficulty
discontinuing prescribed benzodiazepines. More investigations are needed
on the medical necessity of chronic benzodiazepines and strategies for
increasing guideline concordant care.
Sperm competition influences sperm quality and seminal plasma protein expression among territorial males of the courtship cichlid
Authors: Morita Masaya , Satoh Shun , Itoh Takeshi , Kohda Masanori , Awata Satoshi
Published: August 2023

Sperm competition drives the plasticity of sperm quality and seminal
fluid. However, how environmental and behavioral factors influence sperm
competition and its outcome on the plasticity of sperm quality are
unknown. In this study, we show males can asses the sperm competition
level, and their fertilization-promoting sperm traits changes according
to intensity. The promiscuous Tanganyikan cichlids Ophthalmotilapia
ventralis perform their fertilization in the female mouth cavity. Sperm
competition occurs in the female mouth as sperm is collected from
multiple males. Behavioral (i.e., courtship success rates [CSR]) and
environmental (density of spawning sites [DS]) factors are related
to sperm collection. Seminal plasma glycoprotein 120 (SPP120) aids in
sperm immobilization and aggregation, and sperm quality (longevity and
velocity) could increase the probability of siring offspring. Based on
an assumption of the involvement of DS and CSR on sperm collection, DS
and CSR could influence the expression of SPP120 and sperm quality. We
examined how sperm quality and SPP120 affect sperm
competition-associated CSR and DS. Sperm longevity and velocity were
positively correlated with DS. SPP120 expression was also positively
correlated with CSR and DS. The plasticity of sperm quality and amount
of SPP120 result in high fertilization competency according to sperm
competition level.
Identification of Source Faults of Large Earthquakes in the Turkey-Syria Border Region Between AD 1000 and the Present, and their Relevance for the 2023 Mw 7.8 Pazarcık Earthquake
Authors: Carena Sara , Friedrich Anke , Verdecchia Alessandro , Kahle Beth , Rieger Stefanie , Kübler Simon
Published: August 2023

The February 6, 2023, M 7.8
Pazarcık earthquake in the Turkey-Syria border region raises the
question of whether such a large earthquake could have been foreseen, as
well as what is the maximum possible magnitude (M) of
earthquakes on the East Anatolian fault system and on continental
transform faults in general. To answer such questions, knowledge of past
earthquakes and of their causative faults is necessary. Here, we
integrate data from historical seismology, paleoseismology,
archeoseismology, and remote sensing to identify the likely source
faults of fourteen M ≥ 7 earthquakes between AD 1000
and the present in the region. We find that the 2023 Pazarcık earthquake
could have been foreseen in terms of location (the East Anatolian Fault)
and timing (an earthquake along this fault was if anything overdue), but
not magnitude. We hypothesize that the maximum earthquake magnitude for
the East Anatolian Fault is in fact 8.2, i.e. a single end-to-end
rupture of the entire fault, and that the 2023 Pazarcık earthquake did
not reach M by a fortuitous combination of
circumstances. We conclude that such unusually large events are hard to
model in terms of recurrence intervals, and that seismic hazard
assessment along continental transforms cannot be done on individual
fault systems but must include neighboring systems as well, because they
are not kinematically independent at any time scale.
Coastal polynyas enable transitions between high and low West Antarctic ice shelf melt rates
Authors: Moorman Ruth , Thompson Andrew F. , Wilson Earle Andre
Published: August 2023

Melt rates of West Antarctic ice shelves in the Amundsen Sea track large
decadal variations in the volume of warm water at their outlets. This
variability is generally attributed to wind-driven variations in warm
water transport towards ice shelves. Inspired by conceptual
representations of the global overturning circulation, we introduce a
simple model for the evolution of the thermocline, which caps the water
warm layer at the ice-shelf front. This model demonstrates that
interannual variations in coastal polynya buoyancy forcing can generate
large decadal-scale thermocline depth variations, even when the supply
of warm water from the shelf-break is fixed. The modeled variability
involves transitions between bistable high and low melt regimes, enabled
by feedbacks between basal melt rates and ice front stratification
strength. Our simple model captures observed variations in near-coast
thermocline depth and stratification strength, and poses an alternative
mechanism for warm water volume changes to wind-driven theories.
An iterative stochastic procedure with a general step to a linear regular inverse problem
Authors: Maouche Fouad
Published: August 2023

In this paper we consider a linear operator equation in a Hilbert space.
Using Hoeffding inequalities, an exponential bound to the solution obtained
by a stochastic procedure is established and the values of the step ak for
which the procedure converges almost completely (a.co) are discussed. An
illustrative application was treated to the solution of a Fredholm integral
equation of the second kind.
Some properties of extended eigenvalues for operators pair
Authors: Ammar Aymen , Bouchama Chaimaa , Jeribi Aref
Published: August 2023

In this paper, we determine some properties of extended eigenvalues for
operators pair. Furthermore, the relationship between this kind of
operators pair and the operators pencils in Hilbert space is established.
A note of some approximation theorems of functions on the Laguerre hypergroup
Authors: Tyr O. , Daher R.
Published: August 2023

This paper uses some basic notions and results on the Laguerre hypergroup K =
[0, +?)xR to study some problems in the theory of approximation of
functions in the space L2 ?(K). Analogues of the direct Jackson theorems of
approximations for the modulus of smoothness (of arbitrary order)
constructed by using the generalized translation operators on K are proved.
The Nikolskii-Stechkin inequality is also obtained. In conclusion of this
work, we show that the modulus of smoothness and the K-functionals
constructed from the Sobolev-type space corresponding to the Laguerre
operator L? are equivalent.
Kontribusi Kepemimpinan Transformational dan Komitmen pada Profesi terhadap Disiplin Kerja Guru
Authors: Sadianah Leni , Ruhiat Yayat , Faturohman Nandang
Published: August 2023

Upaya peningkatan kualitas pendidikan dipengaruhi oleh kedisiplinan guru. Upaya tersebut masih belum maksimal, hal ini dilihat dari masih banyaknya guru yang melanggar kedisipinan kerja tersebut. Penelitian ini bertujuan untuk menganalisis pengaruh kepemimpinan transformational dan komitmen pada profesi terhadap disiplin kerja guru. Jenis penelitian ini adalah expost facto. Populasi penelitian ini berjumlah 550 orang. Dalam penelitian ini, sampel diambil menggunakan tekhnik proporsional random sampling, sebanyak 165 guru. Pengumpulan data menggunakan kuesioner kemudian dianalisis menggunakan analisis regresi sederhana dan analisis regresi ganda dengan bantuan aplikasi IBM Statistic SPSS 25.0. Hasil penelitian menunjukan bahwa terdapat kontribusi yang signifikan antara kepemimpinan transformational terhadap disiplin kerja guru diperoleh persamaan Y=19.700+0,930 dengan koefisien 0,930. Terdapat kontribusi yang signifikan antara komitmen pada profesi terhadap disiplin kerja guru diperoleh persamaan Y=-8.889+1,643 dengan koefisien 1,643. Secara bersama-sama terdapat kontribusi yang sinifikan kepemimpinan transformational dan komitmen pada profesi terhadap disiplin guru diperoleh persamaan Y=-11.086 +0,293+1,294. Hal ini menunjukan bahwa kepemimpinan transformational berpengaruh terhadap disiplin guru dengan koefisien sebesar 0,293, dan komitmen pada profesi (x2) berpengaruh terhadap disiplin kerja guru dengan koefisien sebesar 1,294. Maka, kepemimpinan transformational kepala sekolah dan komitmen pada profesi memberikan kontribusi terhadap peningkatan disiplin kerja guru.
The Learning Module Uses FASTER Learning Model in C Programming Language Courses
Authors: Suryana Febriyanno , Erdisna
Published: August 2023

The low ability of students in the C Programming Language course is due to the need for more use of models and media that suit student needs. This research aims to test the validity and practicality of the learning modules of the two model books: the lecturer's guidebook and the module book & student guide. This research belongs to the type of development research that was developed using the ADDIE model. Data collection used a questionnaire method and interviews with research instruments in the form of validity and practicality test instruments—data analysis techniques using qualitative and quantitative descriptive analysis. The data from the research analysis showed that the results of the expert assessment obtained an average value of 0.90 in the Valid category. Lecturer manual and the average value of 0.87. Module book & student guide with Valid category. The practicality of the lecturer's guidebook produces an average value of 90.09 (Very Practical). Practical module books & student guides produce an average value of 91.20 (Very Practical). It was concluded that the FASTER model is suitable for learning the C Programming Language, and the modules used are very easy to use and help in the learning process.
ZPD Technological Learning Environment In Learning Computational Thinking Skill-Based Mathematics
Authors: Kamid Kamid , Sutrisno Sutrisno , Kurniawan Dwi Agus , Anwar Khairul , Triani Elza , Septi Sabila Eka
Published: August 2023

This research was conducted as an innovation related to learning problems that often occur in students. This research aims to develop a technological prototype of the mathematics-computation learning environment for playing skills using the Zone of Proximal Development (ZPD) approach based on intelligent technology. This type of research is Research and Development using the 4-D model flow (Four-D Models). The sampling technique is purposive sampling. Data collection in this study uses angles for learning environment data sources and computational thinking. Then interviews are used as a source of learning experience data. Data analysis on quantitative data types used descriptive and inferential statistics in the form of independent sample t-tests and the Miles and Huberman model. This study found differences in the computational thinking abilities of male and female students, and the dominant computational thinking abilities were male students. This development research has produced an online learning environment product where the product is valid in the opinion of experts in the good category, exciting and feasible to implement. The learning environment assists and facilitates students in learning mathematics by using technology geared toward improving thinking.
Application of Student Worksheets Based on Hyperdocs in Chemistry Learning on Scientific Creativity
Authors: Poba Detris , Taslima  , Walanda Daud K. , Napitupulu Mery , Rahmawati Sitti
Published: August 2023

Creativity problems are now considered a crucial ability/skill for the future of education and work. Currently, creativity is seen as urgently needing to be improved in the learning process to achieve better learning quality. This research was a descriptive-qualitative that aims to describe the utilization of Hyperdocs towards scientific creativity of SMA Labschool UNTAD Palu students in chemistry learning on the buffer topics The research subjects consisted of 20 students who were obtained based on a purposive sampling technique. The data collection instrument used hyperdocs-based worksheets which consisted of 14 scientific creativity questions that had been validated by a team of experts. Based on the analysis of percentage data and the category of scientific creativity, the test questions in the first and second sessions showed that the average scores for the aspects of unusual uses, problem finding, product improvement, creative imagination, and problem-solving were in a good category. Furthermore, the science experiment and product design aspects are in the sufficient category. So that it can be said that overall the scientific creativity of SMA Labschool UNTAD Palu class XI MIA 1 is in a good category.