bluuebunny/crossref_metadata_2025 huggingface dataset:
A atuação do enfermeiro em radioterapia
Authors: Diegues Sylvia R. S. , Pires Ana Maria Teixeira
Published: October 2022

Este trabalho tem como objetivo mostrar a importância do enfermeiro no setor de radioterapia dando ênfase a três níveis de atuação: administrativo, assistencial e educacional. Em decorrência dos avanços técnico-científico da área da saúde, foi necessário a criação de novos serviços impondo os profissionais de saúde - entre os quais o enfermeiro - a necessidade de se atualizar e se adaptar a esse processo de desenvolvimento. Atualmente se tem reconhecido a importância do atendimento do enfermeiro aos pacientes que se submetem à quimioterapia, na radioterapia, entretanto ainda são poucos os serviços que valorizam e dispõem de um enfermeiro especializado. Os autores relatam suas experiências administrativas no que se refere ao processo de gerenciamento do serviço e a sua competência quanto à elaboração de relatórios administrativos, supervisão da equipe, coordenação do agendamento dos pacientes em tratamento, entre outras atividades. Quanto à área assistencial o enfermeiro é visto como um profissional diferenciado que necessita de conhecimento especializado e habilidades específicas para desenvolver as suas atividades na área de radioterapia. Enfatiza-se a importância da Consulta de Enfermagem e todas as suas implicações. Quanto ao aspecto educacional mostram os autores que esta ação se encontra presente nas áreas relatadas. Eles destacam o treinamento dos funcionários, o acompanhamento dos estagiários de enfermagem, reciclagem para a enfermagem e atividades extra-hospitalares. Esta conquista de novos espaços vem demonstrar o interesse pela aquisição de conhecimentos técnicos científicos do enfermeiro e, nas instituições de saúde, este profissional vem se destacando como elemento imprescindível e insubstituível em relação à qualidade da assistência prestada, desenvolvendo uma atenção individualizada e buscando formas de integração entre o conhecimento e a ação.
Suporte nutricional pediátrico
Authors: Pinho Nivaldo Barroso de , Pacheco Solange Almeida , Baluz Katia Gomes , Najman Henry Luiz , Ferman Simma
Published: October 2022

O objetivo deste trabalho é avaliar os efeitos do suporte nutricional sobre o estado nutricional de pacientes pediátricos hipercatabólicos, e analisar os efeitos da utilização de produtos de suporte enteral de adultos em pacientes pediátricos. Foram avaliados dois pacientes pediátricos, ambos do sexo masculino com 4 e 5 anos. Apesar de suporte nutricional empregado haver permitido a manutenção dos pacientes em Balanço Nitrogenado Positivo, garantindo-lhes, uma evolução favorável que se reflete na melhora da concentração de proteínas séricas, o que só foi possível com a identificação da Taxa de Catabolismo Protéico, não recomendamos dietas enterais de adulto para crianças imunodeprimidas face ao risco de contaminação das formulas, o que pode proporcionar infecções oportunistas.
Carcinoma mucoepidermóide avançado das glândulas salivares
Authors: Franzi Sérgio Altino , Carvalho Marcos Brasilino de
Published: October 2022

O presente estudo é baseado numa série de 18 casos avançados de carcinoma mucoepidermóide de glândulas salivares maiores e menores. Os estudos histológicos realizados por dois patologistas evidenciaram 16 pacientes portadores de tumores de glândulas salivares maiores e menores com o diagnóstico de carcinoma mucoepidermóide, sendo 4 de baixo grau, 4 de grau intermediário e 8 de alto grau de malignidade. Nos 2 casos restantes foram mantidos os diagnósticos iniciais sem a realização de subclassificação. Neste estudo revisamos os casos de carcinoma mucoepidermóide mostrando que a glândula parótida foi a mais afetada. Quanto aos fatores que exerçam influência no controle da doença e na sobrevida, foram analisados o grau de diferenciação em relação à distribuição por sexo, idade, localização anatômica, estádio clínico e taxa de recidiva. A correlação do parâmetro T da classificação TNM, com a sobrevida mostrou que os casos do estádio T3 apresentaram sobrevida em cinco anos em torno de 41,6% e do estádio T4,17,0%. Observamos uma diminuição das taxas de sobrevida global quando o parâmetro N progrediu de NO para N3; para os tumores classificados como NI e N3 a sobrevida em 3 anos foi de 0%.
Primary splenic angiosarcoma: case report and literature review
Authors: Venegas Luís Fernando , Pohlmann Paula Ratfin , Balbinot Alexsandra Lima , Schuck Eduardo , Oliveira Carla T. M. de , Frank Klaus J. , Dillemburg Carlos F. , Costa Mário S. B. da , Rivero Luis Fernando R. , Pütten Antonio C. K.
Published: October 2022

This paper describes a case of an aggressive primary splenic angiosarcoma in a 29-year-old man and makes a review of its clinicai findings, pathologic reports, treatment and prognosis. Angiosarcomas comprise less than 1% of soft tissue sarcomas, and only a small percentage of these tumors arise in the spleen. These tumors usually represent a diagnostic challenge for the pathologist in view of its variegated histology, and the development of new immu-nohistochemical markers for vascular tumors like CD31 (platelet-endothelial cell adhesion molecule) helps to rule out other diagnoses. There is no standard chemotherapy treatment for angiosarcomas, and the prognosis of splenic angiosarcoma is particularly poor.
Fisioterapia pré-operatória em pacientes candidatos à cirurgia por neoplasia de cabeça e pescoço
Authors: Oliveira Benedito Valdecir de , Wosiacki Filho Woldir , Oliveira Adriana de , Pires Rosemari Alves , Mazzaro Mark Andrey , Romani Julio Celestino Pedron , Ramos Gyl Henrique A. , Costa Cesar , Torres Roberto Jorge de Almeida
Published: October 2022

A partir da correlação entre a incidência de neoplasias de cabeça e pescoço e o tabagismo, e deste com as alterações funcionais semelhantes às descritas na Doença Pulmonar Obstrutiva Crônica (DPOC), este trabalho tem por objetivo avaliar a eficiência do tratamento fisioterápico pré-operatório na minimização destas alterações, que na maioria das vezes estão correlacionadas com as complicações pulmonares destas cirurgias. Foram estudados 46 pacientes candidatos à cirurgia por neoplasia de cabeça e pescoço, realizando-se avaliações de Pressão Inspiratória Máxima (PImáx), Ventilação Voluntária Máxima em percentual para o teórico previsto (VVM%), índice de performance de Karnofsky e exame muscular respiratório, antes e após a realização de 10 sessões da seguinte rotina fisioterápica: inaloterapia por impactação associada a Padrão Muscular Respiratório (PMR) 1:1 e carga linear pressórica. A análise estatística dos dados comparados pareadamente pré e pós-tratamento mostrou diferenças significativas em todos os parâmetros de avaliação muscular. Consequentemente podemos concluir que o tratamento fisioterápico pré-operatório como rotina proposta é eficaz na minimização das desordens funcionais ocasionadas pela DPOC.
Ingestão de broto de samambaia e risco de câncer de esôfago e estômago na região de Ouro Preto, MG
Authors: Marliére Cláudia A. , Santos Rinaldo C. , Galvão Márcio A. M. , Soares José F. , Evangelista Cynara L. M. , Gomes Roberto Q. F.
Published: October 2022

A população da região de Ouro Preto, MG, tem o hábito de consumir as folhas jovens de uma planta (Pteridium aquilinum), chamada popularmente de broto de samambaia (BS). A alta incidência de câncer de esôfago e estômago na região, em relação a outras áreas do estado onde o consumo de BS não se verifica, levou-nos a investigar a possível influência da ingestão do vegetal na ocorrência daquelas patologias. Foi desenvolvido um estudo retrospectivo de casos e controles baseado em esquema de vigilância epidemiológica estabelecido nos dois únicos serviços de endoscopia da região. Quarenta e seis casos confirmados histologicamente foram pareados com 40 controles que não apresentavam alterações ao exame endoscópico. O consumo de BS foi identificado através de entrevista com os pacientes próximos, em caso de morte. Os hábitos de fumar e de consumir bebida alcoólica foram também considerados. A medida de associação utilizada foi a “Razão das Chances” (“Odds Ratio”, OR). Pacientes que ingeriam BS apresentaram aumento de 5,47 vezes na “Razão de Chances” para câncer de trato digestivo alto (esôfago e estômago), em comparação com os controles. Na análise multivariada, controlando-se os fatores de confusão como álcool, fumo, sexo e idade, encontrou-se ainda OR de 3,63 vezes para os dois tipos de câncer citados. Calcularam-se ainda os riscos separadamente para cada tipo de câncer, sendo os resultados ainda significativos, ou seja, OR de 3,40 para câncer de esôfago e de 3,45 para câncer de estômago, valores esses que passam para 3,93 e 3,51 respectivamente quando controlados os fatores de confusão acima mencionados. e seis casos
Tumor carcinóide neuroendócrino da mama - Estudo clínico-patológico de seis casos
Authors: Scigliano Horácio M. , Suarez Marisa l. , Daroda Romeu Ferreira , Silva Marco Antônio Pereira da
Published: October 2022

O tumor carcinóide primário da glândula mamária é uma neoplasia muito rara, de existência controversa. Sua histogênese ainda é discutida, sendo a origem mais reconhecida as células basais primitivas ductais. No estudo retrospectivo de 243 carcinomas infiltrativos e "in situ” de tipo ductal e lobular, seguindo estritos critérios de seleção, foram achados seis tumores carcinóides. O material correspondia a mulheres com idade média de 43 anos, que

apresentaram-se com massas palpáveis notadamente nos quadrantes externos da glândula mamária direita. Não foram comprovadas metástases axilares nem síndrome carcinóide. A mamografia mostrou opacidades densas de contornos regulares. A punção citológica com agulha fina sugeriu células neoplásicas de tipo lobular em três casos; hiperplasia lobular atípica em um caso e presença de mucina não específica no resto. No estádio II da doença foi realizada mastectomia de tipo Madden em todos os casos. Macroscopicamente os tumores tinham uma média de 29,8 mm de diâmetro, aspecto sólido em quatro casos e cístico-gelatinoso em dois, e margens bem definidas. O padrão histopatológico mais freqüente foi o basalóide e presença de mucina extracelular compondo 28% do tumor em três casos. Não foram comprovadas mitoses. Os diagnósticos diferenciais incluíram: o carcinoma lobular, o carcinoma mucinoso e as metástases mamárias de carcinóides de outras topografias. Na evolução pós-operatória não foi comprovada recorrência local, disseminação a distância ou óbito numa média de 3,8 anos, sendo que em nenhuma das pacientes realizou-se rádio, químio ou hormonioterapia. Baseados nesses dados propõe-se a quadrantectomia com esvaziamento axilar como primeira forma de tratamento, reservando a mastectomia para um segundo momento.
Os pressupostos teóricos e operacionais do grupo de apoio e reabilitação de pessoas ostomizadas (GARPO): laringectomizados
Authors: Zago Márcia Maria Fontão , Stopa Maria José Rossato
Published: October 2022

O estudo tem o objetivo de descrever os pressupostos teóricos e operacionais do GARPO: Laringectomizados. O interesse pelo tema originou-se de um vazio encontrado na literatura acerca da constituição e operacionalização de grupos de apoio com pacientes com doenças crônicas como o câncer. São apresentadas as principais características do grupo, os conceitos relacionados às questões de apoio, educação à saúde e reabilitação que fundamentam a assistência ao paciente laringectomizado e seus familiares. Esses conceitos também direcionam o processo grupai e estabelecem critérios para a avaliação das atividades desenvolvidas, que têm como eixo integrador, o ensino de pacientes. Os resultados obtidos pelo grupo têm levado os profissionais a buscar pela educação continuada e pela pesquisa para aprimorarem a assistência.
Bioética e Política de Saúde Pública
Authors: Kligerman Jacob
Published: October 2022

O editorial faz um panorama da importância da Bioética como um alicerce que pode ser de decisões equânimes, e das políticas de saúde pública para a oncologia e demais áreas de saúde.
Câncer e Qualidade de Vida
Authors: Kligerman Jacob
Published: October 2022

O editorial apresenta uma análise sobre índices de sobrevida e qualidade de vida, como dois principais objetivos do tratamento do câncer.
Doença de Paget Extramamáría em Região Períneo-ínguino-escrotal
Authors: Junqueira Júnior Gérson , Amaral Renato Luiz , Vedovato Julio Walter , Torres Olavo Machado , Santos Wellington Gemelli dos , Silva Adriano de Lima e , Cartell André
Published: October 2022

A doença de Paget extramamária constitui-se numa patologia rara. Existe uma estreita correlação com carcinoma anorretal quando a doença é perianal. Também está associada com malignidades internas e mau prognóstico. Os autores relatam um caso de Doença de Paget extramamária em região perineo-inguino-escrotal, num homem branco de 59 anos, que apresentava uma lesão de aproximadamente 6 cm de diâmetro, hiperpigmentada e pruriginosa, lesão esta que aumentou de tamanho e que vinha apresentando mínimo sangramento. Os exames de estadiamento foram normais, sem evidência de metástases. O exame anátomo-patológico da lesão revelou aspecto compatível com Doença de Paget extramamária. A conduta então foi a excisão ampliada da lesão e enxerto de pele fina. São discutidos os aspectos referentes à epidemiologia, patologia, estadiamento, prognóstico e tratamento desta neoplasia.
Ergenlerin Okula Bağlanmalarında Algılanan Sosyal Destek ve Okulda Öznel İyi Oluşun Rolü
Authors: Soyyiğit Merve Kadriye , Traş Zeliha
Published: October 2022

Bu araştırmada ergenlerin okula bağlanmalarında algılanan sosyal destek ve okulda öznel iyi oluşun rolünün incelenmesi amaçlanmıştır. Tüm bireylerde olduğu gibi ergenlerde de bağlanma duygusunu hissetmek ihtiyaç olmuştur (Osterman, 2000). Bireyin kendini okula ait hissetmesi, bulunduğu kurumda mutlu olması ve güvende olduğunu bilmesi okula bağlanma düzeyini belirleyebilir (Maddox ve Prinz, 2003). Zamanının çoğunu okulda geçiren öğrencilerin okula bağlanma düzeylerinin yüksek ve mutlu bireyler olabilmeleri bu sebeple üzerinde durulması gereken bir araştırma olarak görülmüştür. Araştırmada ilişkisel tarama modeli kullanılmıştır. Araştırmanın çalışma grubunu çeşitli ilköğretim okulları kurumlarında 6., 7. ve 8. sınıflarda öğrenim gören ortaokul öğrencileri oluşturmaktadır. Araştırmaya 496 kız (%60,3) ve 327 erkek (%39,7) olmak üzere toplam 823 ortaokul öğrencisi katılmıştır. Araştırmanın verileri Çocuk ve Ergenler için Okula Bağlanma Ölçeği, Çok Yönlü Algılanan Sosyal Destek Ölçeği, Ergenler için Kısa Okulda Öznel İyi Oluş Ölçeği ve Kişisel Bilgi Formu hazırlanarak yapılmıştır. Araştırmada; Bağımsız Örneklem t testi, One Way ANOVA, Pearson Korelasyon Katsayısı ve Çoklu Doğrusal Regresyon analiz teknikleri kullanılmıştır. Araştırma sonucunda cinsiyet değişkenine göre, ergenlerin okula bağlanmalarında kız öğrenciler lehine anlamlı bir farklılık bulunmuştur. Sınıf düzeyi değişkenine göre, ergenlerin okula bağlanma düzeyleri 6.sınıfta öğrenim gören öğrenciler lehine anlamlı düzeyde farklılaşmıştır. Ergenlerin okula bağlanma düzeyleri ile algılanan sosyal destek düzeyleri arasında pozitif yönlü orta düzeyde anlamlı bir ilişki bulunmuştur. Ergenlerin okula bağlanma düzeyleri ile okulda öznel iyi oluş ölçeğinin alt boyutu olan okul doyumu arasında pozitif yönlü yüksek düzeyde, okulda duygu arasında pozitif yönlü orta düzeyde anlamlı bir ilişki bulunmuştur. Ergenlerin okula bağlanma düzeyini, algılanan sosyal destek ve okulda öznel iyi oluş %56 oranında yordamaktadır.
A geographical approach to the development of hypotheses relating to Covid-19 death rates
Authors: Skutsch Margaret , Seheult Roger D. , Loya Jaime
Published: October 2022

Covid-19 deaths per million vary greatly between continents, with countries in South America having higher death rates even than Europe and North America, while Asia, Africa and Oceania have death rates which are only a fifth of those in South America.  By analysing national level data on body weight, diet and latitude, we hypothesise and demonstrate that difference in the percentage of people with overweight (BMI > 25) may be the major factor that explains these differences in Covid-19 death rates. Meanwhile, within the group of countries where adult overweight is prevalent (i.e., where more than 50% of the population has BMI > 25), we hypothesise and demonstrate that latitude plays a role, with relatively lower death rates occurring in countries at lower latitudes. We further suggest that these relationships may be explained by two possible medical hypotheses relating to solar radiation: (1) In overweight people there is less penetration to important organs of near-infrared radiation (NIR) which stimulates production of subcellular melatonin, a strong anti-oxidizing factor and (2) In overweight people, fatty tissue holds much of the body´s 25(OH)D3 leaving less circulating in the blood stream.  Several pathways have been proposed by other researchers to explain the link between Vitamin D deficiency and severity of Covid-19, but the possible link of Covid-19 outcome with NIR has not been explored. Latitude, of course, determines the amount of incoming NIR and as well as UV-B, which is the main stimulant for the body´s production of Vitamin D. It may well be that these two physiological processes operate simultaneously.
Transient responses of melatonin to stress
Authors: Zimmerman Scott , Reiter Russel J
Published: October 2022

Melatonin and its metabolites are ubiquitous antioxidants that are produced

in response to reactive oxygen species (ROS) in virtually all cells of the

body. The highest reported melatonin values in plasma and sweat occur during

heavy exercise both indoors and outdoors during the day. The advent of sweat

biosensors with sufficient melatonin sensitivity provides pseudo real-time

evidence that melatonin is produced throughout the body not just in the pineal

gland. The role of the pineal gland appears to be to provide cyclic production

of melatonin for the regulation of circadian rhythms as well as supplemental melatonin

during periods of low cellular activity. 

Melatonin from the pineal gland represents only a small fraction of the

body’s production capacity. Greater than 5 pg/ml min ramp rates for plasma and

sweat melatonin have been reported during strenuous exercise in sunlight as

compared to 0.15 pg/ml min ramp rates for plasma melatonin under dim light

melatonin onset (DLMO) conditions.  Sunlight

and exercise, like fever, generates transient elevated levels of ROS in tissues

with time constants measured in minutes or even seconds making this systemic

antioxidant response potentially protective. Based on a simple accounting of

ROS generated by sunlight, ROS we breathe, ROS we drink, and exercise, it

appears that the body maintains a heightened basal level of ROS as part of its

pathogen defense mechanisms.  Current

human lifestyles and modern enclosed spaces have substantially eliminated over

90% of the ROS which undermines one of the body’s primary defenses. With

advanced age, the inability to maintain this protective barrier appears to make

us more susceptible to disease.
Potassium Sorbate Postharvest Treatment to Control Penicillium spp. Molds and Maintain Quality of ‘Wonderful’ Pomegranates and ‘Anna’ Apples during Cold Storage
Authors: Sh. M. Mahmoud Thanaa , K. M. Shaaban Fatma , M.M.Abo-El Wafa Thauria , M. Ibrahim Wael
Published: October 2022

This study was carried out for two successive seasons 2020 and 2021 in order to evaluate the efficiency dipping of Wonderful pomegranate and Anna apple fruits in potassium sorbate (K-sorb.) at 3% / 2 min to maintain fruit quality and control postharvest diseases caused by Penicillium spp. ( P. italicum and P. sp.) during cold storage. Fruits were stored at 5°C and 85-90% RH for 75 days. The reduction in linear growth was correlated to the increase in potassium sorbate concentrations. Potassium sorbet at 0.06% concentration gave the maximum inhibition of the linear growth of Penicillium spp. Also, the application of potassium sorbate showed the best results in reducing the deterioration of various physical and chemical characteristics of ‘Wonderful’ pomegranate and ‘Anna’ apple fruits during cold storage and extending its storability. Potassium sorbate treatments mitigated the incidence of fruit decay and successfully decreased fruit weight loss and increased SSC: TA ratio, the total phenolic content, and activities of peroxidase and catalase enzymes relative to the control treatment.
Enveloping analysis of data from educational platforms by area of knowledge
Authors:   Universidad Michoacana de San Nicolás de Hidalgo, Castro Coria Eva Grissel , Gómez Monge Rodrigo ,   Universidad Michoacana de San Nicolás de Hidalgo
Published: October 2022

In the presence of the pandemic caused by covid-19, digital platforms were implemented to continue with the education processes from isolation. In the case of higher education that imparts various areas of knowledge, different results were identified in the use of the same digital platforms. In response to this, it was necessary to analyze how the technological characteristics implemented at a higher level in Mexico have influenced the participation, attendance and evaluation of students by area of knowledge. Therefore, a data envelopment analysis was performed to measure the efficiency of the inputs and outputs described by the literature; the limitations of the research was circumscribed by the amount of data to be analyzed. As a result, it was identified that the greater the number of features added to the digital platforms, the better levels of participation, attendance and evaluation of students by academic area. Likewise, when considering future lines of research, it is considered ideal to elaborate on the various methods of digital evaluation, such as the digital portfolio and feedback.
Evaluation of self-regulated learning in university students. Analysis from online education
Authors:   Universidad de Guadalajara, Flores Guerrero Katiuzka , López de la Madrid María Cristina ,   Universidad de Guadalajara
Published: October 2022

A self-regulated student is guided by task-oriented strategies, seeks to achieve his personal goals, and monitors his or her behavior in terms of his goals. This paper presents the results of a quantitative study whose purpose was to describe the components of self-regulated learning used by students in their online learning processes and to determine if there are significant differences in the way that these components are used. In this investigation, a questionnaire was applied to 306 students of online courses, and the data obtained were processed using descriptive statistics and ANOVA of one factor of repeated measures. The results showed that most of the factors and strategies of self-regulates learning are used in an acceptable way; in addition, significant differenceswere found of the motivational component and in the strategies of the behavioral and contextual component. The findings of the study provide instructional designers with information on the aspects that can be emphasizes to motivate students, which would contribute to the development of different types of skills and methods to self-regulate their learning, training that will allow them to advance more successfully through their education, regardless of the modality in which they work.
Predictors in the satisfaction of managing virtual resources: the role of the learner
Authors:   Universidad Nacional Mayor de San Marcos, Díaz-Camacho Renzo Fabrizzio , Rivera Muñoz Jorge Leoncio ,   Universidad Nacional Mayor de San Marcos, Salvatierra Melgar Ángel ,   Universidad Nacional Mayor de San Marcos
Published: October 2022

With the spread of SARS-CoV-2, all universities were forced to implement the virtual modality in their curricula so as not to paralyze the educational system. Likewise, the Universidad Nacional Mayor de San Marcos, located in the city of Lima, Peru, continued with non-face-toface classes through virtual resources to help its students in the learning process. Therefore, this research aimed to determine the factors of the student role that influenced the satisfaction of managing virtual resources. The study procedure included the collection of 184 surveys through Google Forms and the analysis of validity, structural model, reliability and hypothesis tests using the non-parametric Spearman’s Rho test. Some of the limitations of the analysis were due to generational differences and socioeconomic and geographic variables of the participants. This paper found, according to the order of the highest score of the correlation coefficient, that the factors student-content interaction, gamified participation, motivation, self-efficacy in internet and computing, and perceived usefulness predicted the satisfaction of managing virtual resources in students. It was concluded that the five independent variables were significantly correlated in the dependent variable.
Colony size measurement of the yeast gene deletion strains for functional genomics
Authors: Memarian Negar , Jessulat Matthew , Alirezaie Javad , Mir-Rashed Nadereh , Xu Jianhua , Zareie Mehri , Smith Myron , Golshani Ashkan
Published: October 2022

Background: Numerous functional genomics approaches have been developed to study the model organism yeast, Saccharomyces cerevisiae, with the aim of systematically understanding the biology of the cell. Some of these techniques are based on yeast growth differences under different conditions, such as those generated by gene mutations, chemicals or both. Manual inspection of the yeast colonies that are grown under different conditions is often used as a method to detect such growth differences.
Results: Here, we developed a computerized image analysis system called Growth Detector (GD), to automatically acquire quantitative and comparative information for yeast colony growth. GD offers great convenience and accuracy over the currently used manual growth measurement method. It distinguishes true yeast colonies in a digital image and provides an accurate coordinate oriented map of the colony areas. Some post-processing calculations are also conducted. Using GD, we successfully detected a genetic linkage between the molecular activity of the plant-derived antifungal compound berberine and gene expression components, among other cellular processes. A novel association for the yeast mek1 gene with DNA damage repair was also identified by GD and confirmed by a plasmid repair assay. The results demonstrate the usefulness of GD for yeast functional genomics research.

Conclusion: GD offers significant improvement over the manual inspection method to detect relative yeast colony size differences. The speed and accuracy associated with GD makes it an ideal choice for large-scale functional genomics investigations.
A study on impact of Open Innovation Openness on the Practices adopted by Indian Food Processing SMEs on Product Innovation Output
Authors: Sahdev Supriya Lamba , Singh Gurinder Singh , Chawla Mamta , Sharma C S
Published: October 2022

This study throws light on the outline of innovation taking place in Indian Food Processing SMEs with a special focus on open Innovation taking place in these SMEs and the exchange of information or knowledge taking place between inside-out and outside-in parties for the purpose of innovation. In addition, puts special focus on describing how SMEs’ product innovation output related with the effect of outside-in and inside-out exchange of knowledge and information. Further, it analyzes how expenditure on innovation and collaborating with outside parties can help in the predicting product innovation output of Indian Food Processing SMEs. The analysis was done with the help of Jamovi to find out regression between the dependent variable- “Product innovation output” & independent variables- “Extent of openness”, “Inhouse R& D expenditure”, “Purchase of R&D from outside sources”, “Acquiring knowledge from outside sources” and control variable- “Indian Food Processing SMEs”. And towards the end, it contains the summary of the survey done, which suggested that Indian Food Processing SMEs are proactively involved themselves in inside R&D in comparison to the outside R&D and buying or taking license from outside sources. Other than these activities, one more pointer came as a takeaway from the study, product innovation is performed more in comparison to process innovation by the Indian Food Processing SMEs.
The Translation of Complete Taḍmīn (implication of meaning) in the Fifth and Sixth Suwar (Chapters) in the Qur'an into English: An Ongoing Project
Authors: Nouraldeen Abdullah Soliman
Published: October 2022

his paper is a part of an ongoing project which investigates four English translations of complete taḍmīn in the entire Qur’an. It is an extension of Nouraldeen (2020; 2021a; 2021b; 2022) which have studied four chapters so far. This paper proceeds with discussing, analysing and assessing the fifth sūrah (chapter) al-Māʾidah and the sixth one al-Anʕām. The importance, yet the challenge, of complete taḍmīn lies in its invisibility to the translator and its absence in English. The four-element model that was put forward in Nourladeen (2020, p. 240) is used to analyse and discuss the four English Qur’an translations of complete taḍmīn. The theoretical framework of this study is established within the theories of Vinay and Darbelnet (1995, p. 342) and Dickins et al. (2017, pp 48-56), which suggest ‘explicitation’, ‘loss’ and ‘gain’. Textual analysis is applied to the source text and the target text based on two sources and two dictionaries. The four translators are mostly not aware of taḍmīn when translating the Qur’an, except for Abdel Haleem and Khattab in āyah 4 who translate the implicit verb ترك taraka (literally translated as ‘leave’), discounting the translation of the explicit verb طّفر farraṭa (literally translated as ‘neglect’). The Qur’anic style should be taken into consideration when translating the Qur’an unless the translation would sound awkward in English.
Interlanguage Theory Revisited: Implications for the Classroom
Authors: Osman Osman Hassan , Abuoaf Mahmoud , Al-Rahbi Ahmed Hamed
Published: October 2022

The study aimed to investigate the development of learners’ interlanguage. It also tried to track the sources of the errors that they committed. To discover these errors, the researchers adopted a mixed methods approach. The findings revealed that the participants involved actively in learning the target language and their endeavors manifested all types of errors which may indicate that some of these errors are systematic and universal. The errors were classified according to their sources and their impact on students learning. The findings also revealed that the shortcomings of grammatical knowledge and the lack of exposure to the target language might have a negative impact on students’ interlanguage and the production of native-like competence. Some of the errors indicated that the mother tongue interferes, while other errors indicated interlingual and intralingual strategies effect and attempts of simplification and miss-use of grammatical rules. Some suggestions for further research and pedagogical implications were provided.
Susceptibility of Clostridium sporogenes Spores to Selected Reference Substances and Disinfectants
Authors: Chojecka Agnieszka
Published: October 2022

Research on the susceptibility of the spores of anaerobic bacteria such as Clostridium sporogenes or Clostridioides difficile is vital for assessing the sporicidal activity of disinfectants. The diverse susceptibility of anaerobic bacteria spores may lead to different disinfection parameters being determined by laboratories that prepare spore suspensions to test sporicidal effectiveness. The tests were performed using the suspension method according to PN-EN 13704:2018-09. In order to assess the susceptibility of the C. sporogenes spores, the criterion established for the C. difficile ribotype 027 spores was used in accordance with PN‑EN 17126:2019-01. The susceptibility of the C. sporogenes spores to glutardialdehyde corresponded to the susceptibility ranges established for the C. difficile ribotype 027 spores. The C. sporogenes spore suspension was susceptible to low concentrations of peracetic acid (0.01%). A disinfectant containing peracetic acid as the active substance showed high sporicidal activity at a low concentration (1%), a short contact time (15 minutes), and a high organic load (3.0 g/l bovine albumin + 3.0 ml/l sheep erythrocytes), as compared to a disinfectant with glutardialdehyde, which was sporicidal at a higher concentration (2.5%), at a longer contact time

(60 minutes) and lower organic conditions (3.0 g/l bovine albumin). There is a need to define the minimum susceptibility criteria for the C. sporogenes spores to the reference substances most often found in disinfectants with sporicidal activity. Excessive susceptibility of the C. sporogenes spores to reference substances may result in low-performance parameters of disinfection products with sporicidal activity and lead to ineffective disinfection in practice.
Breeding of High Daptomycin-Producing Strain by Streptomycin Resistance Superposition
Authors: Chu Shuaibei , Hu Wenting , Zhang Kaihong , Hui Fengli
Published: October 2022

Daptomycin is a cyclolipopeptide antibiotic produced by Streptomyces roseosporus. It is widely used to treat drug-resistant bacterial infections; however, daptomycin yield in wild strains is very low. To improve the daptomycin production by the strain BNCC 342432, a modified method of ribosome engineering with superposition of streptomycin resistance was adopted in this study. The highest-yield mutant strain SR-2620 was obtained by increasing streptomycin resistance of BNCC 342432, and achieved daptomycin production of 38.5 mg/l in shake-flask fermentation, 1.79-fold higher than the parent strain and its heredity stability was stable. The morphological characteristics of the two strains were significantly different, and the 440th base G of the rpsL gene in the mutant strain was deleted, which resulted in a frameshift mutation. Our results demonstrate that gradually increasing strain resistance to streptomycin was an effective breeding method to improve daptomycin yield in S. roseosporus.
Chain Whispering Games: The Effective Methods of Developing Receptive Language Skills of Children Aged 5 - 6 Years
Authors: Juniati Ratih , Amal Azizah , Syamsuardi Syamsuardi
Published: October 2022

This research examines the Whispering Chain Game on Receptive Language Skills of 5-6-year-old Children in Kindergartens in Makassar City. The purpose of this study was to determine the description of children's receptive language skills before being treated, to find out the description of children's receptive language skills after being treated, and to determine whether or not there was an effect of the chain-whisper game on the receptive language skills of children aged 5-6 years in kindergarten. Makassar city before and after the chain whispering activity was given. The research approach used was a quantitative approach with a Quasi-Experimental Design type of research. The population in this study were students aged 5-6 years in TK Aisyiyah Parangtambung. Sampling in this study is cluster random sampling. The sample in this study was 12 children. A total of 6 children in the experimental group and 6 children in the control group. Data collection techniques used were descriptive statistical analysis and non-parametric statistical analysis. Based on the results of the study, it can be concluded that the receptive language skills of children who were treated with the whisper-chain game method in the experimental class were better than in the control class, while Tcount = 87 > Ttable = 2,228 was accepted, and H0 was rejected while Zcount was = 2.36 and Ztable = 0.4906 was rejected. H1 accepts this proves that the whisper-chain game method has a significant effect on receptive language skills in early childhood.
Breast Cancer Statistics, 2022
Authors: Giaquinto Angela N. , Sung Hyuna , Miller Kimberly D. , Kramer Joan L. , Newman Lisa A. , Minihan Adair , Jemal Ahmedin , Siegel Rebecca L.
Published: October 2022

This article is the American Cancer Society’s update on female breast cancer statistics in the United States, including population‐based data on incidence, mortality, survival, and mammography screening. Breast cancer incidence rates have risen in most of the past four decades; during the most recent data years (2010–2019), the rate increased by 0.5% annually, largely driven by localized‐stage and hormone receptor‐positive disease. In contrast, breast cancer mortality rates have declined steadily since their peak in 1989, albeit at a slower pace in recent years (1.3% annually from 2011 to 2020) than in the previous decade (1.9% annually from 2002 to 2011). In total, the death rate dropped by 43% during 1989–2020, translating to 460,000 fewer breast cancer deaths during that time. The death rate declined similarly for women of all racial/ethnic groups except American Indians/Alaska Natives, among whom the rates were stable. However, despite a lower incidence rate in Black versus White women (127.8 vs. 133.7 per 100,000), the racial disparity in breast cancer mortality remained unwavering, with the death rate 40% higher in Black women overall (27.6 vs. 19.7 deaths per 100,000 in 2016–2020) and two‐fold higher among adult women younger than 50 years (12.1 vs. 6.5 deaths per 100,000). Black women have the lowest 5‐year relative survival of any racial/ethnic group for every molecular subtype and stage of disease (except stage I), with the largest Black–White gaps in absolute terms for hormone receptor‐positive/human epidermal growth factor receptor 2‐negative disease (88% vs. 96%), hormone receptor‐negative/human epidermal growth factor receptor 2‐positive disease (78% vs. 86%), and stage III disease (64% vs. 77%). Progress against breast cancer mortality could be accelerated by mitigating racial disparities through increased access to high‐quality screening and treatment via nationwide Medicaid expansion and partnerships between community stakeholders, advocacy organizations, and health systems.
Influence of Spirulina Platensis in the composition of feed on the content of heavy metals in rabbit meat
Authors: Tytariova O. , Cherniavskyi O. , Kuzmenko O. , Blyzniuk M.
Published: October 2022

An important area for the further development of animal husbandry is to provide humanity with environmentally friendly food. One way to reduce the content of heavy metals in livestock products in general and meat in particular is to feed some feed products that have sorbent properties. For this purpose, a scientific and economic experiment was conducted to study the effect of feeding compound feeds containing 0.5–2% Spirulina platensis to rabbits raised for meat. The experimental period of the research lasted from the 60th to the 120th day of life of young rabbits and ended with a control slaughter. During this period, the live weight of the rabbits, their safety and the amount of feed consumed were monitored. During the control slaughter, the chemical composition of the longest back muscle was studied, as well as the content of Lead and Cadmium. According to the results ofthe experiment it was found that the introduction of compound feed rabbits Spirulina platensis in doses of 0.5–2.0% helps to improve their growth, reduce the content of Cadmium and Lead in meat, reduce the fat content in it and increase the proportion of dry matter and protein. It should be noted that the highest productivity of rabbits was achieved at a feed content of 1.5% of Spirulina platensis, ahead of control counterparts by 7.8% (P<0.01). Instead, the lowest concentration of heavy metals in meat was recorded at the content of 2.0% of the specified feed: Cadmium by 34.1% (P<0.01), and Lead – by 25.9% (P<0.001) less than the control indexes. As for the chemical composition of meat, the highest protein and the lowest fat in it was recorded at 1.5% Spirulina platensis in the feed. Compared to control animals, rabbit meat in this group contained 1.2% more protein and 0.7% (P<0.01) less fat. Thus, 1.5% of Spirulina platensis in the feed for rabbits raised for meat can be considered the optimal proportion.
Key words: rabbits, Spirulina platensis, live weight gain, productivity, Cadmium, Lead, meat.
Analysis of Risks of Fatalities among Personnel oF Federal Firefighting Service of EMERCOM of Russia in 2006-2020
Authors:   Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia, St. Petersburg, Russian Federation, Evdokimov V.I. , Bobrinev E.V. ,   All-Russian Research Institute for Fire Protection, EMERCOM of Russia, Balashikha, Moscow region, Russian Federation, Kondashov A.A. ,   All-Russian Research Institute for Fire Protection, EMERCOM of Russia, Balashikha, Moscow region, Russian Federation, Gudz Yu.V. ,   Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia, St. Petersburg, Russian Federation, Magdanov D.F. ,   Nikiforov Russian Center of Emergency and Radiation Medicine, EMERCOM of Russia, St. Petersburg, Russian Federation, Pankratov Н.А. ,   Department of Strategic Planning and Organizational Work, EMERCOM of Russia, Moscow, Russian Federation
Published: October 2022

The aim of the study is to analyze the risks of fatalities among the personnel of the Federal Firefighting Service of the Ministry of Emergency Situations (EMERCOM) of Russia in 2006-2020 by categories of personnel, causes of fatal injuries, and types of professional activity. Materials and research methods. Injury rates of Russian EMERCOM Federal Firefighting Service personnel were taken for 2006-2015 from the data bank on morbidity, injury, disability, and death during the performance of official duties in the Russian EMERCOM; for 2016-2020 — from the reports of the Ministry of Emergency Situations of Russia. Risks of death were calculated per 100 thousand people or ×10-5. Results of the study and their analysis. Over 15 years (2006-2020), 224 members of the Federal Firefighting Service of the Russian EMERCOM died as a result of injuries received during the performance of their official duties, averaging (15±1) deaths per year. The average annual risk of death was (8.53±0.83)×10-5. That is statistically reliably lower, than the average risk for Russian Federation male workers — (13.23±1.12)×10-5 (p<0.01). The polynomial trends of the indicators of risk of death of Federal Firefighting service personnel and of male workers of the Russian Federation with different significance coefficients of determination show a decreasing trend in the data. The consistency of the trends is low and statistically insignificant (r=0.228; p>0.05), which may indicate the influence of different (multidirectional) leading factors on fatal injuries. The average annual risks of fatal injuries by causes of fatal injuries, types of professional activity and personnel categories were calculated.
Results of the Use of Practical Recommendations on the Organization of Internal Quality Control and Safety of Medical Activity Outside a Medical Organization
Authors:   State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russian Federation, Goncharov S.F. ,   Russian Medical Academy of Continuous Professional Education, the Ministry of Health of the Russian Federation, Moscow, Russian Federation, Baranova N.N. ,   State Research Center – Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, Russian Federation,   Russian Medical Academy of Continuous Professional Education, the Ministry of Health of the Russian Federation, Moscow, Russian Federation, Kuptsov S.A. ,   Hospital of the National Guard Troops of the Russian Federation, Balashikha, Moscow Region, Russian Federation
Published: October 2022

The aim of the study was to assess the results of application of the criteria for controlling the quality and safety of medical activity in the provision of emergency, including specialized emergency, medical care and medical evacuation. Materials and research methods. The results of treatment of 763 emergency patients admitted to the hospital from September 2021 to September 2022 were analyzed. The work of general medical teams of the hospital in rendering emergency medical aid was studied based on medical documents (case histories): 451 patients received medical care during routine activities; 312 patients received medical care within an emergency situation. During the study, methods of expert review and comparative analysis were used. Thirty physicians with the highest medical category in the specialty “organization of health care and public health” and with work experience of not less than 5 years were involved as experts. In order to check sufficiency of criteria for quality control of medical care, the authors developed a special questionnaire, in which experts were asked to assess on a 10-point scale the significance of each indicator and their sufficiency for a complete description of all possible clinical situations. The results were assessed by statistical analysis using the capabilities of Microsoft Excel tables. Study results and their analysis. The results of the study showed that the most significant criterion of quality control of field forms of work in pre-hospital and hospital periods is the timeliness of medical evacuation, as well as the need to include additional indicators to assess patients with especially dangerous infections in the practical recommendations for the organization of internal quality control and safety of medical activity outside a medical organization.
Physico-Chemical Properties of Pigment in Garden Pansy (Viola × Wittrockiana Gams.)
Authors: Liu Miaomiao , Mu Jinyan , Zhu Xiaopei , DU Xiaohua , Liu Huichao
Published: October 2022

Pansy is a good potential resource for natural pigments due to its rich flower colours. In the present study, pigment from a pansy breeding line, E01, was extracted and its solubility in different reagents and stability under various environmental conditions were investigated. The pigment extracted displayed watersoluble property and was also dissolved in acid (HCl) and alkaline (NaOH) reagents and relatively polar solvents, but insoluble in nonpolar solvents. The pigment-water solution had an absorbance peak at 238 nm with amaranthine colour under acidic conditions. It was stable in aqueous solution under normal conditions. However, it was easily spoiled when exposed to high pH (> 4), high temperature (> 80℃) or under intense light exceeding 170000 lx. The stability of pigment was significantly influenced by Cu2+, but scarcely affected by Na+, Mg2+ and Ca2+. These results will be helpful for commercial prospects of pansy pigment in natural food colour industry.
Bangladesh J. Bot. 51(3): 433-438, 2022 (September)
Eco-Friendly Processing of Momordica Charantia L. Based Chemical Free Functionally Enriched Nectar And Evaluation of Its Nutritional Profile
Authors: Singh Shivali , Sharma Anshu , K Rahul Reddy , Samota Mahesh Kumar
Published: October 2022

The study was conducted to utilize functional attributes of Momordica charantia juice extract by mixing with papaya pulp for imparting yellow-orangecolour of its carotenoids and aonla juice with high Vitamin C to develop Momordica charantia blended functional nectar beverage without any preservative and synthetic food colorant. The ratio of 50 : 25 : 25 of bitter gourd juice extract, aonla juice and papaya pulp with best sensory scores on a nine-point hedonic scale was optimized for the processing of the blended beverage. Functional profile in terms of quality attributes such as reducing sugars (8.39%), DPPH activity (64.20%), total phenolics (41 mg/100 ml), carotenoids (0.58 mg/100 ml), and ascorbic acid (28.8 mg/100 ml) were recorded best in organic honey-based spiced blended nectar. However, charantin content (0.111 mg/100 ml) was found highest in plain bitter gourd beverage. Organoleptic scores and rich functional profile recorded during studies strongly indicated a positive perception of consumers and the need for commercialization.
Bangladesh J. Bot. 51(3): 445-453, 2022 (September)