bluuebunny/crossref_metadata_2025 huggingface dataset:
Adaptive motor recreation in the structure of vacation training camps for goalball players
Authors: Lerner Viktoriia L. , Khlystov Pavel A.
Published: December 2021

The training macrocycle of goalball players includes 52 weeks and in addition to group and individual training, theoretical classes, sports competitions, etc. implies training camps. This needs to achieve continuity of the educational and training process, preparation for competitions, active recreation and recovery of disabled athletes. At the initial training stage, only summer and winter training camps are organized for goalball players twice a year. Summer three-week training camps include morning and evening classes. Morning training sessions following the goals of the initial training stage were mainly aimed at developing physical fitness and developing the game practice of goalball players. Evening training sessions were recreational, the orientation of which was determined by the goals of this type of adaptive physical education. In the introductory part there are construction, greeting, warm-up (varieties of walking and running, jumping, complexes of general developmental exercises with synchronized eye movement), in the main part – specially selected outdoor games for children with visual deprivation aimed at correcting and developing coordination abilities and improving game actions in goalball, in the final part – exercises to prevent the progression of visual impairments. We believe that the inclusion of recreational activities in the structure of the summer training camps of goalball players will contribute to the improvement of technical and tactical game actions, improve their physical fitness in general, correct and develop certain types of coordination abilities, prevent visual impairments, as well as implement the socializing and integrative function of adaptive physical education following the principle of hedonism.
Aproximación a los cultos rurales en el Conventus Clunensis
Authors: Marco Simón Francisco
Published: December 2021

Este trabajo supone una aproximación a los cultos rurales de uno de los conventos de la provincia Tarraconensis. Partiendo de una concepción del paisaje sagrado como algo “encantado” y dotado de agencia y en transformación continua, se analizan los diversos tipos de lugares en los que se optimiza la relación con el mundo sobrenatural: espacios naturales (santuarios rupestres,  cuevas y bosques sacros, espacios acuáticos) y otros cuyo carácter viene determinado por la epigrafía votiva. Finalmente, se consideran los posibles santuarios relacionados con los tránsitos en relación con la trashumancia y las actividades ganaderas, así como los agentes atestiguados epigráficamente, pertenecientes sobre todo al ámbito privado.
Feminicidios en América Latina y el Caribe. Las respuestas posibles desde las organizaciones de mujeres para colmar vacíos legales
Authors: D’Angelo Eugenia
Published: December 2021

América Latina es uno de los territorios del mundo más inseguros para ser mujer, siendo el femicidio/feminicidio la expresión más dramática de la violencia que soportan las mujeres. Pese a ello, los Estados latinoamericanos y caribeños no generan información actualizada, interseccional, ni de libre y fácil acceso sobre estos crímenes, impidiendo la comprensión de la complejidad de escenarios y dificultando la elaboración de políticas públicas efectivas, eficientes y sostenibles en el tiempo para dar respuesta a este flagelo.
PROBLEMS OF AGE AND GENETIC DIAGNOSTICS OF QUATERNARY DEPOSITS IN THE VALLEY OF THE YENISEI RIVER MIDDLE COURSE (YENISEI – LOWER ANGARA STRATIGRAPHIC REGION AND THE MINUSINSK BASINS AREA)
Authors:   Siberian Research Institute of Geology, Geophysics and Mineral Resources, Mikharevich M. V. , Shpansky A. V. ,   Tomsk State University
Published: December 2021

The article is devoted to the state of stratigraphic exploration maturity of the Eopleistocene – Neo-Рleistocene Quaternary deposits on the boundary of mountain and plain territories in the non-glacial area. The material analysis shows an inadequate rationale of the existing stratigraphic schemes, according to which the ladder of alluvial terraces of these territories was formed sequentially during the Eopleistocene, Neo-Pleistocene and Holocene. The revising of representative sections was carried out, the provision of them with geochronological data, the accuracy of age and genetic diagnostics were evaluated.
ON THE STRATIGRAPHIC SIGNIFICANCE OF THE LOW TERRACES OF THE SUZUN STRATA OF THE UPPER OB RIVER REGION
Authors:   V.S.Sobolev Institute of Geology and Mineralogy of the SB RAS, Zolnikov I. D. ,   Novosibirsk State University,   Institute of Geography of the RAS
Published: December 2021

Studies of the end of the 20th century showed that there are no sediments of the glacial-dammed lakesea, as well as sediments of periglacial alluvium in sections of low terraces of the Upper Ob River region, known as the Suzun Strata. The lower stage of terraces is composed of alluvial sediments, and the upper one is epresented by subaerial complex, which includes both deluvium and aeolian deposits. The height of areas varies significantly and is predetermined by thickness of the subaerial complex in each particular area. Сonsequently, the geomorphological principle does not work when differentiating the Suzun Strata into heterochronous geological bodies of accumulative terraces above the flood-plain.
MORPHOLOGY OF THE FIRST MANDIBULAR TOOTH MICROTUS GREGALIS (RODENTIA, ARVICOLINAE) FROM THE MIDDLE PLEISTOCENE OF THE PRE-ALTAI PLAIN
Authors:   V.S.Sobolev Institute of Geology and Mineralogy SB RAS, Malikov D. G. , Golovanov S. E. ,   V.S.Sobolev Institute of Geology and Mineralogy SB RAS,   Novosibirsk State University
Published: December 2021

In this paper morphological structure of the first lower molar m1 tooth of the narrow-skulled vole from alluvial deposits of the Pre-Altai Plain Middle Neo-Pleistocene is described. Morphological study of the vole remains showed that they belong to the modern species Microtus gregalis. At the same time, the study sample showed significant differences, both in morphological structure and in the size of the first lower molar, in comparison with the recent representatives of the same territory. The set of morphological and morphometric data shows that the studied voles occupy an intermediate position between M. gregaloides of the Early and M. gregalis of the Late Neo-Pleistocene. The ratio of m1 morphotypes also showed the relative primitiveness of the M. gregalis sampling. Morphological study of remains of the narrow-skulled vole from the Solonovka, Petropavlovskoe and Malinovka-4 locations confirmed the previously determined age for sediments containing the remains of microtheriofauna.
Rendimiento académico y evaluación de egreso en un Programa de Estomatología
Authors: Cutipa Luque Mariana , Chávez Lovón Verónica , Carrasco Loyola Milagros
Published: December 2021

Objetivo: Determinar la relación entre el rendimiento académico y la evaluación de egreso en estudiantes de estomatología. Material y métodos: El estudio fue observacional, descriptivo y transversal. La población estuvo constituida por el registro de 45 egresados. Las variables de estudio fueron rendimiento académico en los internados y el rendimiento en la evaluación final de carrera. Resultados: El Examen de Suficiencia Profesional (ESP) promedio fue 11,82 (Mín=8; Máx=15,20) y el Rendimiento académico promedio fue 15,87 (Mín=9,03; Máx=18,40), encontrando una correlación positiva baja (Spearman=0,205). El rendimiento académico promedio en las asignaturas del último año fue en el área de clínica en pacientes adultos, 14,92; clínica en pacientes pediátricos, 15,76; en el área hospitalaria, 15,02; y en el área de salud pública estomatológica, 17,80. El ESP promedio fue: en el área de clínica en pacientes adultos, 11,10; cínica en pacientes pediátricos, 13,83; área hospitalaria, 10,31; salud pública estomatológica, 12,02. Se encontró una correlación mínima a baja en las áreas clínicas y social; en el área hospitalaria la correlación fue negativa mínima. Conclusiones: Existe una tendencia a mejores puntajes en el ESP y el Rendimiento académico en las estudiantes mujeres en comparación a los hombres. No hay relación entre los resultados del Examen de Suficiencia Profesional y el rendimiento académico de las asignaturas e internados del Programa de Estomatología de la Universidad Peruana Cayetano Heredia.
Zoom.us y sus potencialidades para generar aprendizajes significativos en odontología restauradora directa e indirecta: Experiencia inédita.
Authors: Saravia-Rojas Miguel Ángel , Fukuhara-Nakama Mary
Published: December 2021

La COVID-19 generó una emergencia sanitaria que impidió la presencialidad a las aulas en la educación superior afectando el desarrollo académico de la enseñanza de la odontología y de todas las ciencias. Esto ocasionó que las instituciones académicas se organicen de manera adecuada para responder rápida y oportunamente para poder asumir estos nuevos retos. El uso de plataformas para video conferencias que permitan reemplazar las habituales clases magistrales fue la respuesta que se obtuvo y su implementación se realizó en el más breve plazo. El resultado de esta implementación obligó a las instituciones académicas a decidir por algunas de ellas para responder eficazmente al nuevo reto. En este documento compartimos nuestra experiencia con la plataforma Zoom.us durante los cursos de Clínica Integral del Adulto CIA I- 2021 y Clínica Integral del Adulto CIA III-2021 brindado a los alumnos del V y VII semestre respectivamente de la carrera de Estomatología. En esta experiencia se describe la percepción del uso de las herramientas que dicha plataforma posee y cómo ellas ayudan a generar experiencias de aprendizaje significativas.
The Relationship Between Level of Knowledge and Behaviors of COVID-19 Prevention among Indonesian Population
Authors: Shari Weni Widya
Published: December 2021

Introduction: Currently, there are no specific drugs to cure COVID-19, so it is an important strategy to be implemented in the community to increase knowledge and preventive behavior in order to prevent transmission. The purpose of this study was to see the relationship between the level of knowledge and preventive behavior against COVID-19 among Indonesian population.Methods: This study used an analytical method with a cross-sectional design. Samples were taken from the people of Depok City as many as 406 people. The independent variable was knowledge and the dependent variable was preventive behavior. The instruments used were questionnaires on the characteristics of the respondents and knowledge and behavior with online questionnaire via Google Forms. The sampling technique was non-probability sampling with a consecutive sampling method. Data analysis used descriptive analysis test, Chi-square and correlative hypothesis test.Results: The results showed that respondents have good knowledge (56.9%) and good prevention behavior (75.9%). The largest source of information about COVID-19 respondents was from Television News (84.4%). There was a significant relationship between the level of knowledge and preventive behavior toward COVID-19 (p=0.000). Moreover, there is a significant relationship between age (p=0.000), gender (p=0.000), education level (p=0.000) and work status (p=0.016) with knowledge.Conclusion:The findings suggest that the local government should initiate an innovative program of health education focusing on knowledge and preventive behavior toward COVID-19 at a community level. The strategies to combat COVID-19 will require community involvement to control and prevent the disease outbreak.
ХІРУРГ-ВІРТУОЗ МИКОЛА СКЛІФОСОВСЬКИЙ: СТОРІНКИ ЖИТТЯ, ПОВ̓ЯЗАНІ З УКРАЇНОЮ
Authors: Мандрик-Мельничук М. В. , Коцур Г. Г. , Крокош П. К.
Published: December 2021

У статті проаналізовано життя та діяльність одного з найвидатніших вчених-медиків, справжнього хірурга-віртуоза, мецената, громадського діяча Миколи Скліфосовського. Особлива увага приділена комплексному дослідженню маловідомих сторінок особистого життя, пов’язаних з Україною, кар’єрного зростання, досягнень, унікальних методик оперування хворих, застосування власних хірургічних розробок. Показано роль М. Скліфосовського і становленні та розвитку військово-польової хірургії та санітарної справи, заснуванні клінік, дослідницьких інститутів в Києві, Москві та Петербурзі.

Ключові слова: хірургія, хірургічна патологія, меценат, клініка, «замок Скліфосовського», військово-польова хірургія, санітарна справа.
ФОРМУВАННЯ ІСТОРИЧНОЇ ПАМ’ЯТІ В ПІДРУЧНИКАХ З ІСТОРІЇ УКРАЇНИ: ДО ТА ПІСЛЯ ЄВРОМАЙДАНУ
Authors: Дворкін І. В. , Телуха С. С. , Харченко А. В.
Published: December 2021

Події в Україні, пов’язані з Євромайданом та Революцією Гідності, помітно вплинули на гуманітарну сферу, призвели до дискусій навколо проблеми національної пам’яті, актуалізували обговорення явищ, особистостей, понять української історії. У статті простежено еволюцію резонансних тем української історії XX ст., представлених у шкільних підручниках з історії. Дослідницький підхід базується на розумінні того, що контекст суспільно-політичних процесів, зокрема інтелектуальних дискусій стосовно національної пам’яті, впливає на написання шкільних текстів з вітчизняної історії.

Ключові слова: освіта; суспільство; національна пам’ять; підручник; історія України.
A Method for Predicting the Influences of Bearing Support Stiffness and Position on the Vibrations of a Flexible Rotor System
Authors: Liu Jing , Tang Changke
Published: December 2021

The bearing support stiffness and position can greatly affect the vibrations of flexible rotor systems (FRSs). However, most previous works only focused on the effect of the bearing support stiffness on the critical speeds or modal characteristics including the natural frequencies and mode shapes of rigid rotor systems (RRSs). The previous studies missed the combined effects of the bearing support stiffness and position. To overcome this issue, an analytical method of a FRS based on the finite element (FE) method is proposed. Our model considers the bearing support stiffness and rotational inertia of FRS. The frequency equation of FRS is established for solving the critical speeds. The critical speeds and modal deformations of FRS from our model and the numerical model based on a commercial software are compared to verify the effectiveness of the presented method. The effects of the bearing support stiffness and position on the critical speeds of FRS are analyzed. The results show that the critical speeds are positively correlated with the bearing support stiffness. The critical speeds of FRS are also greatly affected by the bearing position. This study can provide some guidance for the optimization design method of bearing support stiffness and position in FRSs.
SOCIAL NETWORK ANALYSIS TECHNIQUES (SNA): an applied research method to investigate the role of the Canadian Ministry of Health in combating COVID-19
Authors: Paulino Rita de Cássia Romeiro
Published: December 2021

In this study we present a proposal for digital methods using Social Network Analysis (ARS) techniques as a product that materializes in ways to investigate data from social networks. Through such methods, we research the potential of these techniques to investigate the topology of networks and the individual and collective actions of their actors. As an example, we adopted as a case study the Twitter profile of the Ministry of Health of Canada to examine actors and communication strategies in combating the pandemic. These actors played a leading role in distributing information against Covid-19. As a contribution, we identified that, through the methods adopted, it was possible to perceive a triangulation in the communication of government agents with their public, in addition to identifying communication strategies in combating the pandemic.
TÉCNICAS DE ANÁLISE DE REDES SOCIAIS (ARS): um método de pesquisa aplicada para investigar atuação do Ministério da Saúde do Canadá no combate a Covid19
Authors: Paulino Rita de Cássia Romeiro
Published: December 2021

A pesquisa aplicada é um método ou um conjunto de etapas processuais para desenvolvimento de produtos ou sistemas inovadores. Neste estudo pretendemos apresentar o as Técnicas de Análises de Redes Sociais como um produto que se materializa em várias técnicas de investigação de Redes. Tem o objetivo de investigar o potencial das Técnicas de Análises de Redes Sociais como um método de Pesquisa Aplicada que pode elucidar as ações individuais e coletivas em rede. Como estudo de caso vamos examinar como o Ministério da Saúde do Canadá se comunicou através do Twitter no combate a Pandemia. Como resultado identificamos um triângulo eficaz na comunicação de atores governamentais que exerceram um papel de liderança na distribuição de informações contra a Covid19 através do perfil do Ministério da Saúde e de seus perfis públicos.
DIREITOS CULTURAIS FUNDAMENTAIS DOS POVOS INDÍGENAS
Authors: Munhós Luyse Vilaverde Abascal Munhós , Aguilera Urquiza Antônio Hilário
Published: December 2021

O histórico constitucional brasileiro demonstra que o integracionismo, pautado pelos regimes de tutela e assimilação cultural dos povos indígenas, apenas foi superado com a Constituição Federal de 1988, que inaugurou o paradigma multicultural de reconhecimento da diversidade cultural, reconhecendo aos indígenas sua organização social, costumes, línguas, crenças e tradições. Contudo, mesmo após mais de 30 anos da promulgação da Constituição, as reivindicações indígenas persistem pela efetivação de seus direitos culturais fundamentais, afinal, a sobrevivência física e cultural desses povos pressupõe o respeito ao direito sobre as terras ocupadas e aos seus modos próprios de organização social. O objetivo do presente artigo é verificar a contribuição do multiculturalismo estampado na ordem constitucional vigente para a consolidação dos direitos culturais dos indígenas. Para tanto, é realizada uma pesquisa de caráter exploratório, bibliográfico, documental e qualitativo. Por fim, os resultados alcançados apontam a insuficiência do modelo multiculturalista para a efetiva proteção da singularidade étnica e cultural dos povos indígenas, visto que a consagração dos direitos culturais fundamentais desses povos demanda, mais do que o reconhecimento da diversidade cultural, a inclusão e participação dos viventes da norma na construção do significado de dignidade humana e direitos básicos.
FILME “O SORRISO DE MONA LISA”
Authors: Scherch Vinícius , Alves Fernando de Brito , Scherch Sandra Santos Rosa
Published: December 2021

O artigo propõe uma intersecção entre o filme “O Sorriso de Mona Lisa” e a crítica ao patriarcalismo dominante da sociedade. Para viabilizar o desenvolvimento e a articulação entre direito e cinema, foi adotado o caminho de estabelecer um referencial teórico apoiado em três autores principais: Friedrich Engels, Judith Butler e Pierre Bourdieu. Embora cada autor tenha seu estilo próprio, buscou-se aqui um lugar comum para a crítica ao patriarcalismo e para a leitura de conjecturas que desencadeiam o não-lugar da mulher. Por isso foi utilizada a metodologia hipotético-dedutiva e a pesquisa do tipo bibliográfica. A conclusão a que se chega é de que embora tenham ocorrido avanços no plano do ordenamento normativo, aspectos da tradição, da cultura e da moral acabam dificultando e inviabilizando a emancipação feminina e sua luta política para fazer valer seus direitos.
Experimental Evaluation of Dry Powder Inhalers During In- and Exhalation Using a Model of the Human Respiratory System (xPULM™)
Authors: Pasteka Richard , Schöllbauer Lara , Santos da Costa Joao Pedro , Kolar Radim , Forjan Mathias
Published: December 2021

Dry powder inhalers are used by a large number of patients worldwide to treat respiratory diseases. The objective of this work is to experimentally investigate changes in aerosol particle diameter and particle number concentration of pharmaceutical aerosols generated by five dry powder inhalers under realistic inhalation and exhalation conditions. The active respiratory system model (xPULM™) was used as a model of the human respiratory system and to simulate a patient undergoing inhalation therapy. A mechanical upper airway model was developed, manufactured and introduced as a part of the xPULM™ to represent the human upper respiratory tract with high fidelity. Integration of optical aerosol spectrometry technique into the setup allowed for evaluation of pharmaceutical aerosols. The results show that the upper airway model increases the resistance of the overall system and act as a filter for bigger particles (>3 µm). Furthermore, there is a significant difference (p < 0.05) in mean particle diameter between inhaled and exhaled particles with the majority of the particles depositing in the lung. The minimum deposition is reached for particle size of 0.5 µm. The mean particle number concentrations exhaled are 2.94% (BreezHaler®), 2.66% (Diskus®), 10.24% (Ellipta®) 2.13% (HandiHaler®) and 6.22% (Turbohaler®). In conclusion, the xPULM™ active respiratory system model is a viable option for studying interactions of pharmaceutical aerosols and the respiratory tract in terms of applicable deposition mechanisms. The model can support the reduction of animal experimentation in aerosol research and provide an alternative to experiments with human subjects.
Germline Variants of CYBA and TRPM4 Predispose to Familial Colorectal Cancer
Authors: Zhu Lizhen , Miao Beiping , Dymerska Dagmara , Kuświk Magdalena , Bueno-Martínez Elena , Sanoguera-Miralles Lara , Velasco Eladio A. , Paramasivam Nagarajan , Schlesner Matthias , Kumar Abhishek , Yuan Ying , Lubiński Jan , Bandapalli Obul Reddy , Försti Asta , Hemminki Kari
Published: December 2021

Familial colorectal cancer (CRC) is only partially explained by known germline predisposing genes. We performed whole genome sequencing in 15 Polish families of many affected individuals, without mutations in known CRC predisposing genes. We focused on loss-of-function variants and functionally characterized them. We identified a frameshift variant in the CYBA gene (c.246delC) in one family and a splice site variant in the TRPM4 gene (c.25-1 G>T) in another family. While both variants were absent or extremely rare in gene variant databases, we identified four additional Polish familial CRC cases and two healthy elderly individuals with the CYBA variant (odds ratio 2.46, 95% confidence interval 0.48-12.69). Both variants led to a premature stop codon and to a truncated protein. Functional characterization of the variants showed that knockdown of CYBA or TRPM4 depressed generation of reactive oxygen species (ROS) in LS174T and HT-29 cell lines. Knockdown of TRPM4 resulted in decreased MUC2 protein production. CYBA encodes a component in the NADPH oxidase system which generates ROS and controls, e.g., bacterial colonization in the gut. Germline CYBA variants are associated with early onset inflammatory bowel disease, supported with experimental evidence on loss of intestinal mucus barrier function due to ROS deficiency. TRPM4 encodes a calcium-activated ion channel, which in a human colonic cancer cell line controls calcium-mediated secretion of MUC2, a major component of intestinal mucus barrier. We suggest that the gene defects in CYBA and TRPM4 mechanistically involve intestinal barrier integrity through ROS and mucus biology, which converges in chronic bowel inflammation.
An Extensible Computing Platform for Heavy Quantum Simulation Workloads
Authors: García Andrés , Ranilla José , Alonso Alvarez Raul , Meijueiro Luis
Published: December 2021

The shortage of quantum computers, and their current state of development, constraints research in many fields that could benefit from quantum computing. Although the work of a quantum computer can be simulated with classical computing, personal computers take so long to run quantum experiments that they are not very useful for the progress of research. This manuscript presents an open quantum computing simulation platform that enables quantum computing researchers to have access to high performance simulations. This platform, called QUTE, relies on a supercomputer powerful enough to simulate general purpose quantum circuits of up to 38 qubits, and even more under particular simulations. This manuscript describes in-depth the characteristics of the QUTE platform and the results achieved in certain classical experiments in this field, which would give readers an accurate idea of the system capabilities.
Interfacial Stabilities, Electronic Properties and Interfacial Fracture Mechanism of 6H-SiC Reinforced Copper Matrix studied by the First Principles Method
Authors: Shu Yao , Zhang Shao Wen , Xiong Yong nan , Luo Xing , He Jia zhen , YIn Cui cui , Ding Xiao yong , Zheng Kai hong
Published: December 2021

The interfacial mechanics and electrical properties of the SiC reinforced copper matrix composites were studied via the first principles method. The work of adhesion (Wad) and the interfacial energies were calculated to evaluate the stabilities of the SiC/Cu interfacial models. The carbon terminated (CT)-SiC/Cu interfaces were predicted more stable than those of the silicon terminated (ST)-SiC/Cu from the results of the Wad and interfacial energies. The interfacial electron properties of SiC/Cu were studied via the charge density distribution, charge density difference, electron localized functions and partial density of the state. The covalent C-Cu bonds were formed based on the results of the electron properties, which further explained the fact that the interfaces of the CT-SiC/Cu are stable than those of the ST-SiC/Cu. The interfacial mechanics of the SiC/Cu were investigated via the interfacial fracture toughness and ultimate tensile stress, and the results indicate that both CT- and ST-SiC/Cu interfaces are hard to fracture. The ultimate tensile stress of the CT-SiC/Cu is nearly 23GPa, which is smaller than those of the ST-SiC/Cu of 25 GPa. The strains corresponding to their ultimate tensile stresses of the CT- and ST-SiC/Cu are about 0.28 and 0.26, respectively. The higher strains of CT-SiC/Cu indicate their stronger plastic properties on the interfaces of the composites.
Anti-Inflammatory Effects of Phlebia sp. Extract in Lipopolysaccharide-stimulated RAW 264.7 Macrophages
Authors: Lim Eui Hyeon , Mun Seul-Ki , Kim Jong-Jin , Chang Dong-Jo , Yee Sung-Tae
Published: December 2021

Lichens are a life form in which algae and fungi have a symbiotic relationship. A lichen has various biological activities, including anti-inflammatory and anti-proliferative activities. Inflammation is a response caused by various factors, such as infection by pathogens or tissue damage; excessive reactions can contribute to the etiology of chronic diseases, such as asthma, brain damage, and serious tissue damage. This study demonstrates the anti-inflammatory effect of ethyl acetate extract from Phlebia sp. on NF-κB and AP-1 pathways in the lipopolysaccharide-treated RAW 264.7 cell. Especially, Phlebia sp. extract inhibits the phosphorylation of AP-1 signaling (c-Fos and c-Jun) and its upstream MKK/MAPKs (MKK4, MKK7 and JNK), which induced a decrease in the production of the inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), interleukin-1β (IL-1β), and granulocyte-macrophage colony-stimulating factor (GM-CSF) in downstream of AP-1 signaling. Furthermore, Phlebia sp. extract inhibited the production of final inflammatory effector molecules involved in AP-1 signaling, including nitric oxide (NO) and prostaglandin E2 (PGE2). Here, we report that Phlebia sp. extract has the potential to be developed as an anti-inflammatory agent.
Effects of a Nutritional Supplement (DiRelaxTM) On Anxiety in Dogs
Authors: Scandurra Anna , Mastellone Vincenzo , Pero Maria Elena , Musco Nadia , Iommelli Piera , Lucrezia Alfredo Di , Malgeri Andrea , Tudisco Raffaella , D’Aniello Biagio , Cortese Laura , Lombardi Pietro
Published: December 2021

This study aimed to investigate the efficacy of DìRelaxTM, a nutraceutical formulated to reduce anxiety in dogs. The CBARQ questionnaire, some clinical investigations, and the impossible task test were performed in dogs before and after the treatment. Results showed an ameliorative effect on the performances of treated dogs during the solvable phases, with a significant decrease of the time needed to solve the task. No behavioral difference was found between treated and untreated anxious dogs during the unsolvable phase. According to the results from the C-BARQ questionnaire, some of the behaviors appear improved. In general, this study suggests that DiRelaxTM can be safely administered with no adverse effects and can exercise a beneficial effect on anxious dogs by enhancing their cognitive abilities.
A Genomic Comparative Analysis of Bacillus Coagulans Unravels the Genetic Potential of MA-13 Strain for Biotechnological Applications
Authors: Aulitto Martina , Martinez-Alvarez Laura , Fiorentino Gabriella , Limauro Danila , Peng Xu , Contursi Patrizia
Published: December 2021

The production of bio-chemicals requires the use of microbial strains with efficient substrate conversion and excellent environmental robustness, such as Bacillus coagulans spp. So far the genomes of about 50 strains have been sequenced. Herein, we report a comparative genomic analysis of nine strains on the full repertoire of CAZymes, secretion systems, and resistance mechanisms to environmental challenges. Moreover, B. coagulans Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) immune system along with CRISPR-associated Cas) genes, was also analysed. Overall, this study expands our understanding of the strains genomic diversity of B. coagulans to fully exploit its potential in biotechnological applications.
Large-Scale Printed Chinese Character Recognition for ID Cards Using Deep Learning and Few Samples Transfer Learning
Authors: Li Yi-Quan , Chang Hao-Sen , Lin Daw-Tung
Published: December 2021

In the field of computer vision, large-scale image classification tasks are both important and highly challenging. With the ongoing advances in deep learning and optical character recognition (OCR) technologies, neural networks designed to perform large-scale classification play an essential role in facilitating OCR systems. In this study, we developed an automatic OCR system designed to identify up to 13,070 large-scale printed Chinese characters by using deep learning neural networks and fine-tuning techniques. The proposed framework comprises four components, including training dataset synthesis and background simulation, image preprocessing and data augmentation, the process of training the model, and transfer learning. The training data synthesis procedure is composed of a character font generation step and a background simulation process. Three background models are proposed to simulate the factors of the background noise and anti-counterfeiting patterns on ID cards. To expand the diversity of the synthesized training dataset, rotation and zooming data augmentation are applied. A massive dataset comprising more than 19.6 million images was thus created to accommodate the variations in the input images and improve the learning capacity of the CNN model. Subsequently, we modified the GoogLeNet neural architecture by replacing the FC layer with a global average pooling layer to avoid overfitting caused by a massive amount of training data. Consequently, the number of model parameters was reduced. Finally, we employed the transfer learning technique to further refine the CNN model using a small number of real data samples. Experimental results show that the overall recognition performance of the proposed approach is significantly better than that of prior methods and thus demonstrate the effectiveness of proposed framework, which exhibited a recognition accuracy as high as 99.39% on the constructed real ID card dataset.
The Organization of the Pig T-cell Receptor Gamma (TRG) Locus Provides Insights Into the Evolutionary Patterns of the TRG Genes Across Cetartiodactyla
Authors: Linguiti Giovanna , Giannico Francesco , D'addabbo Pietro , Pala Angela , Caputi Jambrenghi Anna , Ciccarese Salvatrice , Massari Serafina , Antonacci Rachele
Published: December 2021

The domestic pig (Sus scrofa) is a species representative of the Suina, one of the four suborders within Cetartiodactyla. In this paper, we reported our analysis of the pig TRG locus in comparison with the loci of species representative of the Ruminantia, Tylopoda and Cetacea suborders. The pig TRG genomic structure reiterates the peculiarity of the organization of Cetartiodactyla loci in TRGC “cassettes”, each containing the basic V-J-J-C unit. Eighteen genes arranged in four TRGC cassettes, form the pig TRG locus. All the functional TRG genes were expressed, and the TRGV genes preferentially rearrange with the TRGJ genes within their own cassette, which correlates the diversity of the gamma-chain repertoire with the number of cassettes. Among them, the TRGC5, located at the 5’ end of the locus, is the only cassette that retains a marked homology with the corresponding TRGC cassettes of all the analyzed species. The preservation of the TRGC5 cassette for such a long evolutionary time presumes a highly specialized function of its genes, which could be essential for the survival of species. Therefore, the maintenance of this cassette in pigs confirms that it is the most evolutionarily ancient within Cetartiodactyla, and it has undergone a process of duplication to give rise to the other TRGC cassettes in the different artiodactyl species in a lineage-specific manner.
PERICLASE-SPINEL REFRACTORY MODIFIED ТІО2
Authors: Borysenko Oksana , Logvinkov Sergii , Shabanova Halyna , Ostapenko Igor , Gaponova Olena
Published: December 2021

Over the past decades, the development and improvement of refractory materials for lining high-temperature zones of rotary kilns continues. The main requirements for refractory products for lining rotary kilns for cement clinker roasting are: high density and ultimate compressive strength, low porosity and gas permeability, increased abrasion resistance, low thermal conductivity, high corrosion resistance and the ability to form a protective layer.Today, the main goal of modern researchers is to create a heat-resistant refractory with a flexible structure that ensures its integrity at high temperatures and mechanical loads, which have the ability to form a protective coating layer. In this work, a technological approach has been tested for introducing a vibro-milled modifier (briquette based on a high-alumina component and a titanium-containing additive) into the composition of the raw charge for periclase-spinel refractory in the form of a pre-synthesized product containing crystalline phases of the Al2O3 – TiO2 – FeO system. The basis for the production of periclase-spinel refractories modified with TiO2 is the four-component system MgO – Al2O3 – FeO – TiO2, on the basis of thermodynamic calculations of which the content of individual components of the charge was selected and the operational characteristics were predicted. The interrelation of physical and mechanical properties with the content of individual components in the initial charge warehouses is shown, and the directions of solid-phase processes with their participation are noted. The features of the microstructure of the sample material are noted in relation to the formation of an optimal set of properties. It is shown that the nature of the organization of micropores is favorable for increasing the thermal stability of the material, which complements the phase adaptation mechanism also with the structural effect of damping mechanical stresses during thermal cycling.
INDUCTIVE PARAMETRIC EDDY-CURRENT TRANSDUCER (IPEP) FOR MEASURING ELECTRICAL AND TEMPERATURE PARAMETERS OF WASTEWATER FROM BREWING PRODUCTION
Authors: Sebko Vadim , Babenko Volodymyr , Pyrozhenko Yevheniia
Published: December 2021

The possibility of using the theory of operation of a differential inductive parametric  eddy-current transducer (IPET) for measuring the electrical and temperature parameters of a sample of acidic and alkaline wastewater is investigated. The need for the development of new informative methods for measuring the physicochemical parameters of wastewater is proved, in the realization of which a promising method of purification is selected. On the basis of a differential scheme for switching on two parametric converters: with exemplary purified water and a converter in which a test tube with a sample of waste water from a brewing production is placed, a differential informative method for measuring the electrical and temperature parameters of the liquid under study is proposed, which is based on the analysis of the components of the difference signal of phase shift angles measured electrical components of the switching circuit signals. The basic relationships that describe the operation of the IPET with the sample of the controlled liquid are given. The scheme of switching on differential IPET with a liquid sample, which is placed in a glass test tube, is considered; the differential scheme provides for heating the sample during measurements to simulate the production conditions of brewing production. Universal transformation functions are given that relate the components of the IPET signals with the specific electrical conductivity χt.s. and the temperature t of the wastewater sample from brewing production, that is, the dependence of the phase difference signal Δj on the generalized parameter A and the dependence of the absolute increment in the specific electrical conductivity Δχ on the temperature t of the wastewater sample, in the investigated temperature range.
MODELING OF PRODUCING PRESSURE IN HETEROGENEOUS OIL-BEARING RESERVOIRS
Authors: Lubkov Mikhail , Zakharchuk Oksana , Dmytrenko Viktoriia , Petrash Oleksandr
Published: December 2021

Numerical modeling of the distribution of the reservoir pressure drop in the vicinity of an operating well was carried out taking into account the inhomogeneous distribution of filtration characteristics (permeability and oil viscosity) in the near and distant zones of the well operation in order to study the practical aspects of filtration in heterogeneous oil-bearing formations based on a combined finite-element-difference method for non-stationary problem of piezoconductivity. The use of the combined finite-element-difference method enables to combine the advantages of the finite-element method and the finite difference method: to model geometrically complex areas, to find the value at any point of the object under study, while the implicit difference scheme.
It is shown that the intensity of filtration processes in the vicinity of the operating well depends mainly on the permeability, and, to a lesser extent, on the viscosity of the oil. Moreover, the influence of the permeability of the oil phase in the remote zone (Rd < 5 m) is greater than the effect in the close zone (Rd > 5 m) of the operating well. In the case of low permeability of the oil phase in the vicinity of the existing well, to maintain stable oil production, it is necessary to place an injection well near the production well. Using the method suggested, it is possible to predict the effect of the injection well on the formation pressure distribution in the formation.
The scientific novelty of the work lies in the study of the influence of the heterogeneous permeability and oil viscosity distribution on the reservoir pressures distribution around the wells by modeling filtration processes based on a combined finite-element-difference method.
The practical significance of the research results comes down to confirming the close relationship between the heterogeneity of the porous medium and the reservoir pressures distribution around an operating producing well. The combined finite-element-difference method used in this work can be used to solve other filtration problems (for example, to calculate the gas saturation of a reservoir, create a method for calculating well flow rates, assess the effect of injection wells on filtration processes).
THE DOMESTICATED DONKEY: I – SPECIES CHARACTERISTICS
Authors:   Saim Boztepe, YÄ±lmaz Orhan
Published: December 2021

The objective of this study is to define domestic donkey giving some information about species characters including taxonomy, origin, terms, ecology, form, lifespan, behaviour, vocal expression, colour, markings, and relationships with other species, religion and myth.The donkey is an odd-toed ungulate. Donkeys may be the only hoofed animal domesticated first in Africa, and apparently the first to be domesticated for transport.
Investigation of the microstructure evolution of 7CrMn2WMo economy‑alloyed steel in a new design forging tool implementing shear deformations
Authors: Lezhnev S. N. , Naizabekov A. B. , Volokitina I. E. , Panin E. A. , Kuis D. V. , Stepankin I. N.
Published: December 2021

Inthis paper, a new forging technology realizing intense shear deformations during processing with a tool for its implementation was considered, and the influence of the proposed forging technology on the microstructure evolution of 7CrMn2WMo economy‑alloyed steel was revealed. A comparative analysis of the results of the microstructure evolution when forging blanks made of 7CrMn2WMo steel according to the proposed and current technologies proves the usefulness of a new design tool instead of the currently used flat strikers, since forging in the proposed forging tool provides more intensive and uniform processing of the cast structure over the entire section of the workpiece compared to forging in the flat strikers.
Autonomous Streaming Space Objects Detection Based on a Remote Optical System
Authors: Baranova V. S. , Saetchnikov V. A. , Spiridonov A. A.
Published: December 2021

Traditional image processing techniques provide sustainable efficiency in the astrometry of deep space objects and in applied problems of determining the parameters of artificial satellite orbits. But the speed of the computing architecture and the functions of small optical systems are rapidly developing thus contribute to the use of a dynamic video stream for detecting and initializing space objects. The purpose of this paper is to automate the processing of optical measurement data during detecting space objects and numerical methods for the initial orbit determination.

This article provided the implementation of a low-cost autonomous optical system for detecting of space objects with remote control elements. The basic algorithm model had developed and tested within the framework of remote control of a simplified optical system based on a Raspberry Pi 4 single-board computer with a modular camera. Under laboratory conditions, the satellite trajectory had simulated for an initial assessment of the compiled algorithmic modules of the computer vision library OpenCV.

Based on the simulation results, dynamic detection of the International Space Station in real-time from the observation site with coordinates longitude 25o41′49″ East, latitude 53o52′36″ North in the interval 00:54:00–00:54:30 17.07.2021 (UTC + 03:00) had performed. The video processing result of the pass had demonstrated in the form of centroid coordinates of the International Space Station in the image plane with a timestamps interval of which is 0.2 s.

This approach provides an autonomous raw data extraction of a space object for numerical methods for the initial determination of its orbit.
What Is Really Happening When Parent and Child Wells Interact?
Authors: Jacobs Trent
Published: December 2021

When trying to understand the well-to-well events known as frac hits and fracture-driven interactions (FDIs), the first idea to embrace is this: they are not all the same.

“And the key physical mechanisms are not the same,” said Mark McClure, who added that, “Until you’ve really dialed in on what those are, you’re really in the dark.”

McClure is the cofounder and CEO of ResFrac Corp. In March, the modeling firm began a multiclient study to diagnose the relationships between parent and child wells—or what many consider to be the ultimate subsurface challenge facing the shale sector.

Participating operators are Marathon Oil, Hess Corp., Pioneer Resources, Arc Resources, Birchcliff Energy, SM Energy, and Ovintiv Inc. These independent E&Ps represent a cross section of some of the most active plays in North America: the Midland and Delaware basins and the Bakken and Montney shales.

But what makes the study unique, McClure said, is that it involves 10 rich data sets from well pads that were subjected to a number of cross-validating diagnostics: tracers, pressure/interference monitoring, geochemistry, and fiber optics. ResFrac has been using that data to calibrate its coupled reservoir-fracture models to see what knobs clients might want to turn in the future to improve well economics.

The study is also trying to unearth some firm answers about what is really happening during offset stimulations, why it is happening, and what can be done to mitigate negative outcomes. ResFrac and its clients expect to wrap up this part of the study by the year’s end and to submit an abstract for an SPE technical conference in 2022.

As the study nears an end, McClure offered some of his key observations that he noted are supported by previous research found within industry literature.

So, What’s the Worst That Can Happen?

A growing chorus of subsurface experts consider unwanted chemical reactions in the fracture network as one of the major damage mechanisms resulting from FDIs. McClure is not only among them, he said chemical effects represent the “worst” that can happen when parents and children interact.

“This is where you see wells get hit, they lose 80% of their production, and it doesn’t come back,” he explained. Some in the industry have taken to calling the byproduct of these chemical reactions “shmoo” or “gunk.” For answers as to why this is happening, McClure points to two technical papers in particular.
Decision Tree Regressions Estimate Liquid Holdup in Two-Phase Gas/Liquid Flows
Authors: Carpenter Chris
Published: December 2021

This article, written by JPT Technology Editor Chris Carpenter, contains highlights of paper SPE 203448, “Decision-Tree Regressions for Estimating Liquid Holdup in Two-Phase Gas/Liquid Flows,” by Meshal Almashan, SPE, Yoshiaki Narusue, and Hiroyuki Morikawa, University of Tokyo, prepared for the 2020 Abu Dhabi International Petroleum Exhibition and Conference, Abu Dhabi, held virtually 9–12 November. The paper has not been peer reviewed.

In the authors’ study, a machine-learning predictive model—boosted decision tree regression (BDTR)—is trained, tested, and evaluated in predicting liquid holdup (HL) in multiphase flows in oil and gas wells. Results show that the proposed BDTR model outperforms the best empirical correlations and the fuzzy-logic model used in estimating HL in gas/liquid multiphase flows. Using the BDTR model with its interpretable representation, the heuristic feature importance of the input features used in building the model can be determined clearly.

Introduction

Machine-learning approaches in predicting HL in multiphase flows have been recently studied to improve prediction accuracy compared with existing empirical correlations. However, these approaches ignore the heuristic feature importance of the input parameters to the predicted HL values. The heuristic feature importance can help provide better insight into the issues associated with HL studies, such as the liquid-loading phenomenon. To the best of the authors’ knowledge, the present study is the first work that shows how decision-forest regression predictive models can predict HL accurately.

Data Acquisition

The performance and the predictive power of a machine-learning model relies greatly on the quality and completeness of the data set used in building the model. The data sets used in training and testing the predictive model are experimental and were collected from the literature (111 data points). Air/kerosene and air/water mixtures were used in obtaining the 111 experimental data points. In this study, this data set is divided into three different subsets: training, validation, and testing.

The data sets consist of the properties of HL, the superficial gas velocity (Vsg), the superficial liquid velocity (Vsl), pressure, and temperature (T). The statistical measures of the data sets are shown in Table 1 of the complete paper.