bluuebunny/crossref_metadata_2025 huggingface dataset:
СОВЕРШЕНСТВОВАНИЕ АНАЛИТИЧЕСКОГО ИНСТРУМЕНТА
PESTEL В СИСТЕМЕ СТРАТЕГИЧЕСКОГО УПРАВЛЕНИЯ
ПРОМЫШЛЕННЫМ ПРЕДПРИЯТИЕМ
Authors: Махди Сохейли Могадам Сейед Махди
Published: July 2021

Характер решений в области стратегического управления, как правило, сложный и неструктурированный. Соответственно, одной из наиболее важных проблем руководителей стратегического уровня является повышение качества и обоснованности принятия решений. В данном исследовании предпринята попытка решить данные вопросы с помощью нейронных сетей, которые являются одним из наиболее важных методов решения проблем с применением новых вычислительных методов машинного обучения, позволяющих максимизировать выход реакции сложных систем. В рамках исследования осуществляется использование PESTEL в качестве одного из инструментов и фреймворков для анализа внешних факторов, влияющих на промышленные предприятия. Факторы PESTЕL обычно выходят за рамки того, на что организация может напрямую влиять. Эти факторы определяют тенденции развития окружающей среды и предоставляют важную информацию для проведения SWOT-анализа промышленных предприятий; дают обоснованные гипотезы для разработки стратегии предприятий. Для определения степени и серьёзности воздействия факторов, индикаторов и критериев в работе использовался процесс иерархичес¬кого анализа и, исходя из количества и серьёзности неопределённостей, в расчётах учитывалось понятие риска. Одним из факторов рассмотренного инструмента стратегического анализа является политический фактор, выступающий одним из самых сложных и неструктурированных в рамках изучаемого метода. Результаты исследования показали, что использование искусственной нейронной сети позволяет провести оценку политического фактора в рамках инструмента стратегического анализа PESTEL и даёт возможность вырабатывать более обоснованные управленческие решения. Среди двух рассмотренных моделей оптимизатор SGD демонстрирует лучшие результаты по сравнению с оптимизатором ADAM.
SOSIALISASI PHBS DENGAN PEMBAGIAN PANCURAN AIR DAN SABUN CUCI TANGAN KEPADA WARGA RT.09 KELURAHAN LEMPAKE KOTA SAMARINDA
Authors: Siska Oktaviani  , Miftahul Jannah
Published: July 2021

Hasil observasi pada salah satu RT di Kelurahan Lempake yaitu RT. 09 didapatkan informasi bahwa fasilitas untuk mencuci tangan masih jarang ditemui di tempat-tempat keramaian di RT tersebut, kemudian masih ada warga yang tidak memakai masker ketika berinteraksi dengan warga lain serta kurang sadarnya warga sekitar mengenai pola hidup bersih dan sehat.  Pengabdian masyarakat ini bertujuan memberikan pengetahuan dan pemahaman mengenai PHBS dalam rangka pencegahan penyebaran Covid-19 kepada warga RT. 09 Kelurahan Lempake. Metode yang dilakukan pada sosialisasi ini melalui penyampaian materi mengenai protokol kesehatan dan PHBS dengan membagikan video edukasi cuci tangan melalui grup WhatsAppwarga serta pembagian pancuran air dan sabun cuci tangan. Kegiatan sosialisasi PHBS dengan pembagian pancuran air dan sabun cuci tangan kepada warga di lingkungan RT. 09 mendapat dukungan yang positif, baik dari ketua RT. 09 maupun warga sebagai salah satu bentuk kegiatan untuk mengedukasi warga bahwa dengan mencuci tangan dengan sabun dengan langkah-langkah yang benar maka warga sudah berpartisipasi dalam rangka memutus mata rantai penyebaran Covid-19.
PENINGKATAN KOSAKATA BAHASA INGGRIS MENGGUNAKAN METODE GAME “ SPELLING BEE” PADA SISWA KELAS VIII MTSN 7 KOTA PADANG
Authors: Dwi Megista Putri  , Rasmita  , Dian Christina
Published: July 2021

Kegiatan ini diusulkan dengan pertimbangan bahwa pada umumnya siswa pemula cenderung menyukai kegiatan belajar dengan tindakan dan gerakan yang berbeda. Masalah lainnya yang ditemui ialah siswa biasanya mudah bosan dengan aktifitas pemebelajaran setelah10 menit dan menyebabkan rentang perhatian pendek dan kurangnya daya ingat. Berdasarkan permasalahan diatas, maka tim pengabdianmasyarakat ingin memotivasi siswa untuk belajar bahasa Inggris dengan metode yang menarik dan tentunya disukai oleh siswa yaitu Spelling Bee. Kegiatan ini dilaksanakan sebagai umpan balik dari tindakan analisis kebutuhan yang telah dilakukan oleh tim pengabdi terhadap siswa MTSN 7 kota Padang. Diharapkan setelah kegiatan ini terlaksana, siswa mampu mengetahui bakat dan minat belajar di sekolahakan kebutuhan bahasa Inggris yang mana bisa diaplikasikan dalam kegiatan sehari-hari.
Synthesis, Characterization, in silico and in vitro Studies of Transition Metal Complexes with Biologically Active Ligand as Antigout Agent Colchicine
Authors: Gaikwad Vaishali , Sabale Vaibhav , Khade Bhimrao
Published: July 2021

Colchicine is essentially useful in the treatment of gout. In the present work Colchicine Complexes has been prepared with transition metals viz; Copper(II) [Cu(II)], Zinc (II) [Zn(II)], Cobalt (II) [Co(II)], Nickel (II) [Ni(II)] and those checked for molecular docking, it has been observed that Zn(II) and Ni(II) complex has revealed good binding energy than the parent ligand, the increased binding energy of colchicine metal complexes  indicates that, the tubulin polymerization inhibitor tendency is enhanced, consequently antigout property is also increased. As transition metals have antimicrobial activity in themselves, complexes are also characterized for the antimicrobial activity which is enhanced for Cu(II) and Co(II) metals.
Evaluation of in vitro Antioxidant and Cytotoxic Effect of Methanol Extract from aerial parts of Myristica beddomei King ssp. ustulata W.J. de Wilde
Authors: Joy Neethu , Mohan Mahesh
Published: July 2021

Plants are traditionally used for pharmacological activities because of its ability to produce bioactive compounds. Myristica beddomei King ssp. ustulata W.J. de Wilde is an ethnomedicinal plant and it is seen in South Western Ghats of Kerala, India. The present study assessed the phenolic content, flavonoid concentration, in vitro antioxidant and cytotoxic effect of different parts of Myristica beddomei King. The total phenolic contents in the extracts ranged from 96.29 (pericarp) to 314.47 (bark) mg g-1 gallic acid equivalent. The concentration of flavonoids in different plant part extracts ranged from 1.81   to 2.76 mg g-1 equivalent to quercetin. All the parts exhibited potential antioxidant activity with an IC50 value of 2.87 to 9.67 μg ml-1 when compared to the standard ascorbic acid with an IC50 value of 2 μg ml-1 in 1,1-diphenyl-2- picryl-hidrasil (DPPH) method. Bark showed highest activity in terms of DPPH radical scavenging (IC50 value of 2.87 µg ml-1), phosphomolybdenum test (2261.33 ± 1.65 mg g-1 trolox equivalent) and ferric ion reducing antioxidant power (FRAP) (113.1 ± 0.28 µmol Fe2+ µg-1) while pericarp showed low antioxidant activity. The in vitro screening results revealed that the seeds exhibited promising anticancer activity compared to PA1 (Ovarian Cancer) cells (50 % inhibition) were observed at a concentration 100.68 µg ml-1.  In cytotoxicity test L929 (Fibroblast) cell line compared to the other parts pericarp, mace and seed needed higher concentration (>240 µg ml-1) for LC50 value. It is a promising plant for further development of antioxidant agent as it got high content of phenolic compounds and potential antioxidant and anticancer activity.
QUALITY BY DESIGN APPROACH FOR ENHANCEMENT THE DISSOLUTION RATE OF LAFUTIDINE LIQUISOLID TABLETS
Authors: Gohil Tushar , Oza Nishant , Vekariya Hitesh
Published: July 2021

The aim of present work was to enhancing the solubility and dissolution rate of the aquaphobic drug Lafutidine by liquisolid technique. Lafutidine is a H2-receptor antagonist BCS class II drug. Lafutidine compatibility with excipients was evaluated by FT-IR and DSC spectrum. Preliminary trial taken to check the effect of carrier to coating material ratio (R) and non-volatile solvent (PEG- 600) on pre compression and post compression characteristic. Flowable liquid retention potential (Ø -value) and Liquid load factors (Lf) were calculated for required amount of excipients necessary to preparing Lafutidine liquisolid tablet. A 32 full factorial design was employed to check the effect of carrier to coating material ratio R (X1) and PEG- 600 (X2) on hardness (Y1), angle of repose (Y2), % of Cumulative drug release at 5 min Q5 (Y3), and disintegration time (Y4). Multiple linear regression analysis, ANOVA and graphical representation of the influence of factor by 3D plots were performing by using Design expert 7.0. In this study, the following constraints were arbitrarily used for the selection of an optimized batch: Hardness: 3 to 5.5, Angle of repose: 25 to 30, % of Cumulative Drug Release at 5 min (Q5) > 27.09 % and Disintegration time <1.3 min. The desirability value of various dependent variables calculated for determining the optimized batch of tablet and it was also found to be nearer to one. Performance of optimized batch had no shown any significant change at the end of stability study.
In vitro and in vivo anticancer efficacy of Adiantum capillus-veneris L. against some selected human cancer cell lines and on EAC mouse model
Authors: Ayoub Zeenat , Malik Sumera Banoo , Mehta Archana
Published: July 2021

Adiantum capillus-veneris, commonly known as maidenhair fern belongs to family Pteridaceae, has traditionally been used in various medicinal preparations as demulcent, expectorant, emmenagogue, diuretic etc. in the form of oil, paste, decoction and powder. It has also prominent role in hair growing and has anti-microbial, anti-inflammatory, anti-diabetic, anti-nociceptive and antioxidant properties of therapeutic interest. This study aimed to investigate the in vitro cytotoxic activity of fractions of ethanolic extract isolated from the aerial part of A. capillus-veneris against some human cancer cell lines such as colon (HCT-116), lung (A549), breast (MCF-7) and pancreatic (MIA PaCa-2) and tumor cell proliferation/inhibition was assessed using MTT assay. The in vivo anticancer activity of hexane fraction was also evaluated against murine Ehrlich ascites carcinoma (EAC) model. The results confirmed that all the fractions of ethanolic extract exhibited promising in vitro inhibition of tumor cell proliferation when tested against different human cancer cell lines. Among all, hexane fraction proved to be more effective having IC50 values 21.72, 22.67, 26.25 μg/mL, for HCT- 116, A-549, MCF-7, respectively, but chloroform fraction revealed to be more cytotoxic against Mia-PACA-2 having IC50 value 14.72 μg/mL. Higher cytotoxic activity is found to be associated with lower IC50 values. The findings showed that all five fractions exhibited dose-dependent killing capabilities in various human derived cancer cell lines at 48 h of treatment. Hexane fraction was found to inhibit tumour growth development by 16.95%, 41.12% and 82.07% at 50, 100 and 200 mg/kg body weight, respectively. Additionally, this fraction was predicted to be non-toxic at the tested doses. The findings indicate that A. capillus-veneris herb is an antineoplastic agent and suggest that further studies evaluating the isolation of active antitumor compounds from A. capillus-veneris and their mechanism(s) of action are necessary.
Development of bioanalytical standardization parameters of Alocasia indica tuber by HPTLC technique
Authors: Aneshwari Roman Kumar , SAHU ANIL KUMAR , Vyas Amber , JAIN VISHAL
Published: July 2021

Alocasia indica is perennial herb growing widely and used as traditional medicine in India, China and Bangladesh. The divine herb has potent medicinal values for the treatment of different type of illnesses. The HPTLC techniques were used to separate active components from ethanolic extract of tuber part of A. indica. This examination was intended to designed a HPTLC fingerprint profile of crude extract of the plant in ethanol. A HPTLC method for the isolation of various active constituents in A. indica ethanolic extract have been developed and solvent system for quercetin the mobile phase used was toluene: ethyl acetate: formic acid (5:2:1) and for analysis of β-sitosterol the mobile phase used was chloroform: ethyl acetate: formic acid (6:4:1) . In the present investigation, HPTLC fingerprint of extract of dried tuber part of A.  indica have been performed and the results demonstrated that important  information for standardization. The HPTLC system for routine quality control of present species can be used for ethanolic extract and serve in qualitative, quantitative and was appropriate for standardization of the plant.
EX-VIVO: ANTHELMINTIC EVALUATION OF BOMBAX CEIBA STEM EXTRACTS
Authors: Khokra Sukhbir Lal , Gogat Sonia , Narang Rakesh , Devgun Manish
Published: July 2021

Bombax ceiba plant belongs to bombacaceae family and is commonly known as Semal (Hindi) and Cotton tree (English). It has numerous effects like stimulant, astringent, haemostatic, diuretics, antidiarrhoeal, emeticand antipyretic. Major pharmacological activities reported in this plant are hypoglycemic, antianxiety, antibacterial, antiviral and anti-inflammatory. Numerous side effects and increased resistance to anthelmintic drugs prompted us to discover cost effective safe formulation of conventional medicinal plants. In the present study, research work is focused to evaluate the possible anthelmintic effects of Bombax ceiba. To investigate anthelmintic potential of Bombax ceiba plant, different extracts from dried powder stem bark were tested on adult Indian earthworms (Pheretima posthuma) having physiological & anatomical resemblance with human intestinal roundworm parasites. The drugs were divided in 14 groups consisting of test, standard and control. Each group was consisting of six Indian earthworms of approximately same size. Albendazole was used as standard drug while tween80 in normal saline (1:1) was used as control. The result data reveals that all extracts have significant anthelmintic activity as compared to Albendazole taken as standard drug. The methanolic extract at dose of 50 mg/ml concentration showed paralysis time 30±0.96 minutes and death 33.66±0.71 minutes, which is equivalent to standard drug values at dose of 20 mg/ml. Ethylacetate extract at dose of 50 mg/ml showed paralysis at 28.66±0.71 minutes and death at 34.16±1.10 minutes, which proves that it is even better than standard drug in terms of paralysis time and equipotent in terms of time taken for causing death. Thus among the extracts, ethylacetate and methanolic extracts showed maximum activity with least time taken for paralysis and death of earthworms and were found equally potent as Albendazole at a dose of 50 mg/ml. Thus, Bombax ceiba traditional use in helminitic infestation was proved scientifically. On comparing phytochemical evaluation with anthelmintic activity it is assumed that glycosides may be responsible for this activity. A further investigation may lead development of novel anthelmintic drug or formulation with anthelmintic activity.
Fourier Transform Infrared and Chromatographic Fingerprint of Essential Oil from Pogostemon benghalensis (Burm. F.) Kuntze
Authors: Premakumari Pradeep Damodaran , Sarayu Manoj Gopal , Kumaraswamy Murugan
Published: July 2021

The purpose of the present research work is to investigate the functional group and category of secondary metabolites present in the essential oil (Eo) from Pogostemon benghalensis using Fourier transform infrared (FTIR) spectrometry, HPTLC and GC-MS technique. FTIR measures the vibrations of bonds within the functional groups and yields a spectrum that can be considered as biochemical or metabolic fingerprint of the plant product. Using FTIR spectra, it is possible to find out the minor changes of primary and secondary metabolic characteristic functional groups which are responsible for their biological feature of the species. FTIR is a nondestructive, cost effective, user and eco-friendly tool. Pogostemon benghalensis, a wild relative of P. cablin, the highly utilized and adulterated medicinal herb by the native people for the extraction of essential oil Patchouli. The fresh leaves were subjected to hydro distillation for the extraction of the essential oils and were analyzed using the above techniques. The FTIR spectral lines have shown diverse unique peaks of functional groups. FTIR confirmed the volatile compounds and indicated by their functional groups of the essential oils such as C-H (Alkene), C-H (aromatic) and C=C. Similarly, the analysis proved the presence of alcohols, p-substituted alcohols or phenols, alkanes, alkynes, alkenes, aldehyde, ester, ether, aliphatic amines, carboxylic acids, aromatics, ketones, disulphide, alkyl halides, halogen, and nitro derivatives. The intensity and estimation of predominant volatiles were analysed by   HPTLC, which showed 8 peaks with max Rf values ranged from 0.07 to 0.96. Further, the Eo was fractionated by with GC-MS technique and identified 41 volatile fractions in the oil.  Thus, the obtained data provides the biochemical profiles with overlapping signals of a wide array of molecules that are present in the cells. So, the usage of essential oils in pharmacy, cosmetology and aromatherapy industries may be substantiated. Further advanced spectroscopic analysis is required to identify the structure and nature of active principles present in the Eo.
Validation of In-vitro Deposition of Emitted Dose Method for Simultaneous Estimation of Formoterol Fumarate and Glycopyrrolate in combined Dry Powder Inhaler Aerosol Pharmaceutical Dosage Form
Authors: Kotak Ravindra K , Pandya Chintan V , Pandya Aditee C
Published: July 2021

Formoterol Fumarate and Glycopyrrolate Dry powder inhaler is combined aerosol dosage form. The label claim of this combined dosage form is 25 mcg of Glycopyrrolate and 6 mcg of Formoterol Fumarate per respicap. It is prescribed for treatment of Asthma and COPD. Formoterol Fumarate is anti asthmatic drug (Bronchodilator) and Glycopyrrolate is quaternary ammonium compounds which is Anticholinergic Drug. A bronchodilator is a substance that dilates the bronchi and bronchioles, decreasing resistance in the respiratory airway and increasing airflow to the lungs while Glycopyrrolate blocks muscarinic receptors thus inhibiting cholinergic transmission. Glycopyrrolate is also known as Glycopyrronium Bromide, an Anticholinergic agent. It is used to inhibit salivation and excessive secretions of the respiratory tract preoperatively; reversal of neuromuscular blockade; control of upper airway secretions; and part of treatment for peptic ulcer.  The present study aimed to Validate HPLC method for determination of Deposition of emitted dose of Formoterol Fumarate and Glycopyrrolate Analytes. This study covers Precision, Linearity, Accuracy, Robustness, Ruggedness, stability of analytical solution and Specificity.  The chromatographic method uses a reversed phase column Purosphere star RP 18e (125 mm × 4.6 mm x 5 μm). The mobile phase was prepared by mixing Buffer : Acetonitrile : Methanol (68 : 24 : 8 %v/v/v) at flow rate 1.0 ml per min with UV and PDA detector 215 nm, column oven adjusted to 25° C with injection volume 100 μL. The method showed a successful application for determination of Formoterol Fumarate and Glycopyrrolate in Dry powder inhaler pharmaceutical formulation.
Direct Stereoselective Method Development and Validation of Elagolix on Zwitterionic Chiral Stationary Phase by High-Pressure Liquid Chromatography
Authors: Choppari Thirupathi , Gunnam Srinivasu , Chennuru Lakshmi Narayana , Cherla Parameswara Murthy
Published: July 2021

A specific, sensitive and accurate chiral technique has been developed for the quantification of elagolix enantiomer in a drug product. The present research work represents the development and validation of chromatographic technique for the separation of elagolix enantiomers on a chiral stationary phase (CSP) comprising a zwitterionic selector derived from cinchona alkaloid and sulfonic acid CHIRALPAK ZWIX (+)  under isocratic condition containing 50mM Acetic acid and 25mM diethyl amine in water and methanol in the ratio of 02:98 v/v with 0.5 ml min-1 flow rate. Temperature of the column was monitored at 40°C with a resolving factor more than 3.2. The eluted compounds were monitored at 275 nm. The optimized method has high degree of selectivity with lower limiting values of detection and quantitation and were found to be 2.0 ng/ml and 7.5 ng/ml, respectively for the enantiomeric chiral impurity. The developed method was subjected for validation as per the ICH guidelines, produced good findings regarding specificity, accuracy, precision, robustness and linearity.
BIOSYNTHESIS, CHARACTERIZATION, BACTERICIDAL AND TOXIC EFFECT OF SILVER NANOPARTICLES USING Klebsiella pneumoniae STRAIN STC1
Authors: Sharon S. Febina Bernice , Ganesan Anitha
Published: July 2021

Nanotechnology dealt with nanoparticles having a size of 1-100nm used significantly in pharmaceutical science and many other fields. The use of microorganisms in the synthesis of nanoparticles emerged as an eco-friendly method. Klebsiella pneumoniae strain STC1 was isolated from cow’s milk and identified by 16S rRNA sequencing. The biosynthesis was done using the fixed ratio of aqueous solution of the bacterial supernatant and AgNO3 and the colour change was observed which proved the formation of silver nanoparticles. The nanoparticles were characterized by UV-Visible Spectrophotometer, FTIR, XRD and SEM. The nanoparticles were found to have sizes ranging from 15 to 70nm. The antibacterial activity of silver nanoparticles was studied against methicillin resistant Staphylococcus aureus, Clostridium perfringens, Pseudomonas sp. and Proteus sp. The Minimum Inhibitory Concentration of silver nanoparticles was found to be 50µg/ml against methicillin resistant Staphylococcus aureus. The synergistic effect of the silver nanoparticles with commercial antibiotics erythromycin and tetracycline was found to be more evident. The time kill assay and the cytoplasm diffusion assay showed the effectiveness of synthesized silver nanoparticles in the study. The synthesized silver nanoparticles had a great antibacterial potential against methicillin resistant Staphylococcus aureus. The toxic effect of silver nanoparticles revealed that as the concentration of the silver nanoparticles increased, the effect of toxicity increased and the hatching percentage of Artemia cysts decreased. The innovation in this present study is that the biosynthesis of nanoparticles is simple, cost effective, providing good bactericidal and cytotoxic activity and it can represent a future for more therapeutic and pharmacological applications.
Studies on comparative antimicrobial activities of Aerva lanata and Momordica charantia leaf extracts
Authors: Shilpika Nagula , Keerthana Byagari Teena , Srinivas Banka , Rani Gampa Tulja , Maithili Ganga
Published: July 2021

Screening and comparison of antimicrobial action of leaf extract of Aerva lanata and Momordica charantia. Ethyl acetate and methanolic extracts of leaves of plants were screened for antimicrobial activity using the cup plate method and the spread plate method against gram positive and gram negative reference organisms (Bacillus substilis and Escherichia coli).The standard antibacterial agent used for reference is Choramphenicol and the results were calculated as zone of inhibition. Methanolic extract showed comparatively broader and better antimicrobial spectrum than ethyl acetate extract in selected plants. Plant extracts showed dose dependent action, results were similar to the action of the standard Choramphenicol. Extracts of Aerva lanata and Momordica charantia demonstrated antimicrobial activity on tested microorganisms. Methanolic extracts showed higher antimicrobial potential than ethyl acetate extract. Aerva lanata extracts showed better response than Momordica charantia extracts in the cup plate method antibacterial activity with Bacillus substilis and Escherichia coli.
In vivo and in vitro Antidiabetic Characterization of Nymphaea alba leaves
Authors: SINGH GURVIRENDER , AGNIHOTRI SUPRIYA , VERMA SANTOSH KUMAR
Published: July 2021

The study was aimed to trace out antihyperglycemic potentials of Nymphaea alba leaves using in vitro and in vivo approaches. In, in vitro study, determination of IC50 of Nymphaea alba extracts was done using α-amylase and α-glucosidase inhibition assay. In α-amylase, Nymphaea alba methanol extract (NAME) exhibited maximum inhibition 56.77±1.23% at 125µg/ml in comparison to 66.7±0.94 % of standard acarbose. In α-glucosidase, NAME exhibits 59.89±0.92, while standard acarbose showed 70.31±1.25 % inhibition. The in vivo study was performed on diabetic rats, made diabetic by Streptozotocin. 200mg/kg and 400mg/kg NAME was administered orally, which significantly (
Production of value added Oyster mushrooms
Authors: Sailaja Bandhakavi , Radhika Batchu
Published: July 2021

Mushrooms are ironic in nutrimental resources and have converted into one of the common foods in the previous twenty years globally. The types of edible mushrooms are button, milky and oyster mushrooms. The research aimed at value addition of Oyster mushrooms by rising on paddy substrate complemented with two concentrations of four different medicinal plants. The plant parts selected were flowers of Butea monosperma, leaves of Moringa olifera, bark of Cinnamonom zeylianicum, fruits of Corindraum sativum at 5% and 10% concentration.  Different species of oyster mushrooms are available. In the present study Pleurotus florida was selected for value addition. Maximum mycelium running rate was detected in Cinnamon bark (5%) and paddy straw (95%) accompanied group and lowermost running rate of mycelium was observed in Moringa leaf (5%) and paddy straw (95%). The primordial arrival was fast with Cinnamon bark (5%) supplemented group and slowest in Moringa leaf (5%) supplemented group. The mushrooms grownup on Coriander fruit (5%) produced more but the growth was slow. Mushrooms supplemented with Butea flower (5%) exhibited slow growth and yield was next to coriander fruit supplemented mushrooms. The produced mushrooms were subjected to physical evaluation, preliminary phytochemical testing and also tested for estimation of total flavonoids, total phenols, total tannins and total cinnamaldehyde contents. Value addition of Oyster mushrooms was successful with cinnamon bark as cinnamaldehyde was noticed in the Cinnamon bark supplemented group, and also with Moringa leaves as flavonoids was observed in more concentration in Moringa leaf supplemented mushroom group.
Development and Validation of Stability Indicating RP-HPLC Method for the Simultaneous Estimation of Dapagliflozin Propanediol and Metformin Hydrochloride in Tablet Dosage Form
Authors: Patel Nikita Shaileshbhai , Patel Bhavesh Hirabhai
Published: July 2021

A rapid, precise, accurate, specific and simple stability indicating RP-HPLC method was developed for simultaneous estimation of Dapagliflozin Propanediol (DAPA) and Metformin Hydrochloride (MET) in its tablet dosage form. Method was performed on a column C8 Thermoquest, hypersil division of dimension 250 mm × 4.60 mm having particle size 5 micron. The mobile phase used in the method was 10 mM Ammonium Acetate buffer (pH- 4), Methanol and Acetonitrile in proportion of 30:65:05 respectively. The drug was subjected to acid and alkali hydrolysis, oxidation, photolysis and heat as stress conditions. The method was validated for specificity, linearity, range, precision, accuracy, robustness, LOD, LOQ and system suitability. The flow rate was maintained at 0.8 ml/ min and effluent was monitored at 227 nm. The retention time were observed 5.988 min and 4.661 min for DAPA and MET respectively.  The standard curve was found linear over range of 60-140 μg/ml for DAPA and 300-700 μg/ml for MET with correlation coefficient of 0.9996 for DAPA and 0.9994 for MET. The limit of Detection (LOD) of this method was 1.121 μg/ml for DAPA and 6.162 μg/ml for MET. The limit of Quantitation (LOQ) of this method was 3.396 μg/ml for DAPA and 18.674 μg/ml for MET.  The percentage recovery was found to be in the range of 98-102% at three different levels of a standard addition. The precision (repeatability, intra-day and inter-day) of the method was within the limit (RSD<2%). Degradation products produced because of stress studies did not interfere with the detection of DAPA and MET and the assay can thus be considered stability-indicating. Combination tablet was successfully analysed using the developed method.
Tectonic Stress Distribution in the Song Tranh 2 Hydropower Reservoir: Implication for Induced Earthquake
Authors: Hoai Luong Thi Thu , Nguyen Ha Vu Pham , Dinh Nguyen Nguyen , Thi Phuong Thao Hoang , Van Vuong Nguyen
Published: July 2021

The Song Tranh 2 hydropower reservoir was built in Tra My area, Quang Nam province, composing magmatic and high-grade metamorphic rocks of the northern part of the Kon Tum massif. Since the reservoir was put into operation, induced earthquakes have occurred in the Song Tranh 2 hydropower reservoir and its vicinity. Tectonically, the northwest-southeast to east-west striking faults developed strongly. Detailed analysis of slickensides and attitude of faults occurring in the studied area have shown that the northwest-southeast striking faults are reactivated as dextral ones during the Pliocene-Quaternary up to the present day. Based on the geometric distribution of the fault network, kinematic characteristics, and the youngest tectonic stress regime, we computed the distribution of tectonic stress in the studied area. Computation results show two positive anomalies of stress directly related to the northwest-southeast faults numbered 2, 10, 11a, 11b and sub-latitude striking fault numbered 1. These faults run in line with the local river channels and are likely to reactivate and generate induced earthquakes.
Study on Acidity and Neutralizing Ability of Ions in the Chemical Composition of Rainwater
Authors: Ngan Han Thi , Xuan Co Hoang , Thi Thu Ha Pham , Manh Khai Nguyen
Published: July 2021

The acidity in rainwater is mainly controlled by the presence of H2SO4, HNO3 in combination with the ability to neutralize cations in rainwater. pH is an important value in the evaluation of acidity in rainwater. The research used a series of rainwater quality monitoring data from 2005 to 2018 in Vietnam. The research showed that the average pH distribution at 23 stations ranged from 5.83 ± 0.62. The rains with pH <5.6 appear in all years at the research stations. Considering the ability of acid neutralizing to various ions shows that Ca2+ is the main contributor to acid neutralization processes in rainwater, followed by Mg2 +, NH4+, and K+. While Ca2+ always play the highest acid neutralizing role at all stations; Depending on each station, Mg2+ and NH4+  ions play a role in neutralizing acidity in rainwater. The research also shows a match between the trend of H+ concentration and the tendency of cations to contribute to acid neutralization in rainwater.
Conamomum Pierreanum (Gagnep.) Skornick. & A. D. Poulsen (Zingiberaceae), a New Record for the Flora of Vietnam
Authors: Ngoc Anh Luu Dam , Huong Bui Van , Truong Do Van , Cu Luu Dam , Hai Do Van , Hung Nguyen Quang , Thanh Trinh Xuan , Nguyen Thanh Trung
Published: July 2021

Conamomum pierreanum (Gagnep.) Skornick. & A. D. Poulsen, (Zingiberaceae), a previously known species from Thailand and Cambodia, is here reported, as a new record for Vietnam. It is similar to C. rubidum and C. odorum but differs in having a present stilt root; a shorter petiole, 2-3 cm; a larger leaf blade, oblong, 30-50 × 5-8 cm, glabrous; a globose to ovoid inflorescence, arising near the base of rhizome; tomentose outer surface of bract; a 3-toothed bracteole, outer surface hairy; and a smaller filament, yellowish and glabrous. The detailed morphological description, distribution and ecology information, conservation status and a colour plate of this species are given.
Antagonic Activity of Endophytic Bacteria Isolated from Man Trau Grass on Stem Rot Disease Of Pitaya (Hylocereus Undatus)
Authors: Trung Do Quang , Thu Hang Nguyen Thi , Van Dinh Mai , Ngoc Pham Bich Bích , Hang Tran Thi , Anh Luu The , Tien Phi Quyet
Published: July 2021

Endophytic bacteria reside in the intercellular spaces in different plant tissues without causing damage. This study aimed to select endophytic bacterial strains from Man Trau grass (Eleusine indica) that are able to inbibit the fungus A. alternata  causing stem rot disease on pitaya. The result showed that one fungal isolate was pathogenic and caused stem rot disease on dragonfruit. The analysis results based on morphological characteristics and ITS region sequence indicated that the isolated fungal strain is 100% identical to A. alternata. In addition, a total of 16 endophytic bacterial strains were isolated from Man Trau grass samples in Binh Thuan and screened for antifungal activity. Ten bacterial strains with antagonistic activity against A. alternata causing stem rot disease on pitaya were detected. Among those, strain MT47 showed the strongest antifungal activity with an efficiency of 36.67%. Moreover, the result also presented that the antagonistic strain MT47 pocesses the ability of biofilm formation significantly higher than the control. The results suggest that these endophytic bacteria can be used in biocontrol of the stem rot disease on pitaya.
Application of Next Generation Sequencing Genetic Studies of Urea Cycle Disorders
Authors: Huong Nguyen Thi Thu , Kim Lien Nguyen Thi , Hoang Nguyen Huy
Published: July 2021

Urea cycle disorder is a group of rare, inherited metabolic disorders in the pathway transforming ammonia to urea. The mutations in genes coding for 6 enzymes that are participated including carbamoyl phosphate synthase I (CPSI), ornithine transcarbamylase (OTC), argininosuccinate synthase (ASS1), argininosuccinate lyase (ASL), arginase (ARG1), and N-acetyl glutamate synthase (NAGS), and 2 transport systems ((ornithine translocase (ONT1), citrin)) in the urea cycle are responsible for ammonia accumulation in the blood. Hyperammonemia is the cause of severe neurological symptoms and even death. In almost all cases, clinical examinations and biochemical experiments are necessary, but insufficient information for an accurate diagnosis. Mutation analysis is an effective method to confirm the diagnosis and could be the basis for genetic counseling. The rapid development and widely using of next generation sequencing (NGS) have brought incredible advances in molecular diagnosis of genetic diseases in general. In this article, we systematize the UCD genetic studies applying NGS method, thereby providing a basis for not only disease diagnosis but also future research
Peculiarities, factors and trends of financial behavior of youth (on the example of the Republic of Bashkortostan)
Authors: Fatkullina Gulshat Rashitovna , Karimov Aibulat Galimyanovich
Published: July 2021

The object of this research is the youth of the Republic of Bashkortostan. The subject of this research is the financial behavior of youth. Based on the results of online pilot study carried out in the Republic of Bashkortostan via Google Form, the authors analyze the relevant questions pf financial behavior of youth. The survey included the questions that allowed determining the process of formation of financial literacy, degree and level of participation of the key social institutions in teaching the younger generation the fundamentals of financial literacy, as well as financial behavior practices that exist in the families of respondents. Emphasis is placed on the analysis of financial literacy of youth, as it is largely determined by the financial literacy of the population, which includes knowledge, practical skills and skills, and attitudes of citizens in the field of personal finance. The research interest is also focused on the differences in financial behavior of Z generation (zoomers) and Y generation (millennials). The author determines insufficient level of teaching financial literacy at all stages of education, which entails irrational (risky) financial behavior among youth. Half of the respondents can be regarded as poor people; however, they do not seek for solution to change the situation, such as getting themselves a job. As a positive trend, the author notes noted that in a certain way modern youth is concerned about the future and tries to develop the strategies of financial behavior (mostly medium-term and short-term).
The legal meaning of a person’s consent to damage to life or health: international and foreign experience
Authors: Volkova Alina Yur'evna
Published: July 2021

The research subject is international and foreign legislation in which a person’s consent to or request for infringement of their rights and legal interests indicates their acquiescence to their unreliable property management. The author uses dialectical, logical, historical-legal, formal-legal, and comparative-legal research methods which helped to detect various fields of social relations in which the legislation regulating a person’s consent to damage is used, thus hampering the unification of the legal understanding of this facultative phenomenon. The consideration of a person’s consent to damage as a manifestation of private interest in international law and the legislation of particular countries will allow adopting the best practices for the purpose of integrating this phenomenon into the Russian legal realia. The examination of international and foreign legislation regulating a person’s consent to damage to rights or legal interests demonstrates the need for the implementation of this phenomenon in Russia’s legal sphere, which would be a basis for a comprehensive assessment of the situation of the infringement of rights upon a person’s consent or request. The author studies international and foreign legislation to consider the evolution of social relations in which a person can implement his or her right and manage his or her property, and the regulation of the forms of exercising a personal interest consisting in the consent to damage to life and health. The scientific novelty of the research consists in the comprehensive consideration of international and foreign legislative experience in exercising personal right to be subject to damage, which determines the necessity to introduce such a legal phenomenon into the Russian legal realia based on the criteria of social benefit. The author’s contribution to the development of the topic is the suggestion to introduce a person’s consent to damage into the Russian criminal law. 
Sociocultural portrait of the Leningrad member of cooperative (1987-1991)
Authors: Chudetсkii Aleksandr Nikolaevich
Published: July 2021

The subject of this research is the participants of cooperative movement that unfolded in Leningrad in 1987 – 1991. During this period, the country legalized the citizens’ right to establish industrial cooperatives, which de facto have become private enterprises. Leningrad turned into one of the largest centers of cooperative movement in the USSR, and members of the cooperatives – a considerable part of urban society. Attention is given to the situation of cooperatives in Leningrad prior to their transition into the non-state sector of the economy. The author explores such sociocultural characteristics of the cooperative member as the attitude towards socialist system, Soviet regime, experience of party and Komsomol life, work skills, and age characteristics. It is revealed that the majority of participants of cooperative movement prior to transition into the non-state sector of the economy had a stable social status and were loyal to the Soviet system, and many of them held senior positions. Among the members of cooperative were also the members of CPSU and Komsomol activists. Their performance efficiency and high professionalism were often noted by the party and state authorities. This casts doubt on the widespread opinion about the marginal status of the participants of cooperative movement. Moreover, the attempt to attract people not involved in public production was unsuccessful; compared to the working age citizens, householders, pensioners, people with disabilities, and students met in the cooperative community were a rarity. The article relies on the archival documents, newspaper materials, sources of personal origin, as well as the results of interviews conducted by the author with former employees of the cooperative.
Transtorno do espectro autista e habilidades envolvidas no brincar: concepção de uma equipe multidisciplinar
Authors: Lima Mayanny da Silva , Carvalho Valeria Silva , Lima Najra Danny Pereira , Silva Marcus Vinicius da Rocha Santos da , Rocha Gilma Sannyelle Silva , Medeiros Thalia Costa , Medeiros Thais Costa , Silva Maria Camila da , Oliveira Mychelle Maria Santos de
Published: July 2021

Objetivo: Identificar quais os métodos ou procedimentos utilizados pelos profissionais nos atendimentos para desenvolver e potencializar as habilidades da criança autista através do brincar funcional. Métodos: Trata-se de um estudo avaliativo, exploratório, do tipo pesquisa ação, com abordagem qualiquantitativo. Participaram da pesquisa profissionais de uma equipe multiprofissional que atuam nos atendimentos no Centro de Atenção Psicossocial Infanto Juvenil (CAPS-IJ) com pacientes com Transtorno do Espectro Autista (TEA). A coleta de dados foi realizada com o uso de questionários com perguntas abertas e fechadas sobre o tema. Resultados: Diante das respostas obtidas, verifica-se o conhecimento superficial dos profissionais acerca da importância do brincar funcional no atendimento de crianças com TEA, pois ele auxilia no desenvolvimento total, configurando-se como fundamental no processo terapêutico, validando e potencializando as habilidades da criança, usufruindo do lúdico como ferramenta promotora de desenvolvimento. Conclusão: Os resultados demonstram o desconhecimento e a falta de capacitação para o ensino de habilidades por meio do brincar. Por meio deste estudo, enfatiza-se a importância do brincar no processo terapêutico e o conhecimento destes métodos pelos profissionais como ferramenta para aquisição de habilidades.
Reconhecimento dos padrões eletrocardiográficos equivalentes de infarto agudo do miocárdio com supradesnivelamento de segmento ST
Authors: Pagoto Angelo Bruno , Santos Carlos Roberto Rohenkohl Evangelista , Vitorio Felipe Augusto Ferreira , Nobre Marlucia do Nascimento , Sena Rovanda Guimarães , Júnior Irineu Lopes de Alcântara , Júnior Armando Hiroyuki Mori , Ihara Bárbara Pires
Published: July 2021

Objetivo: Avaliar o que as publicações têm tratado sobre a importância de reconhecer precocemente diferentes padrões eletrocardiográficos, mais especificamente os equivalentes de Infarto Agudo do Miocárdio Com Supra do segmento ST (IAMCSST/STEMI). Métodos: Trata-se de uma revisão integrativa, com recorte temporal entre 2010 e 2020. Para elaboração da revisão foi estabelecida questão norteadora: “qual a importância do reconhecimento dos padrões eletrocardiográficos equivalentes de IAMCSST? ”. Para busca de dados foram usadas Biblioteca Virtual em Saúde e Pubmed e foram associados aos descritores em português e inglês “ST Elevation Myocardial Infarction equivalent”, “Electrocardiography” e “Electrocardiography patterns”. Para coleta e análise excluiu-se artigos repetidos, com posterior leitura íntegra. Resultados: A partir da análise das 22 publicações selecionadas, reconhece-se que a avaliação dos diferentes padrões eletrocardiográficos estão aquém do considerado ideal, o tempo hábil na pronta interpretação de exame é tardio e as mudanças dos equivalentes de IAMCSST demonstraram-se como alterações sutis que passam despercebidas por profissionais inexperientes. Considerações finais: Os padrões equivalentes STEMI são pouco reconhecidos na interpretação do ECG e apresentam em sua maioria alta taxa de mortalidade associada a um prognóstico ruim. É necessário que o profissional de saúde tenha acesso a informação dos desenhos eletrocardiográficos de maneira integral.
Vias de parto: percepção e preparo de gestantes de uma unidade básica de saúde
Authors: Souza Ruth Luiza Uchoa de , Chaves Raquel Ferreira , Fonseca Ivana Annely Cortez da
Published: July 2021

Objetivo: Descrever a percepção das gestantes em acompanhamento do pré-natal pelo enfermeiro em uma Unidade Saúde da Família sobre vias de parto. Métodos: Utilizou-se a pesquisa de campo, descritiva, com abordagem qualitativa, à amostragem foi composta por 15 gestantes, a coleta de dados ocorreu na após aprovação no comitê de ética e pesquisa em uma Unidade de Saúde da Família, mediante a aplicação de uma entrevista. Resultados: Foi possível elaborar três grupos temáticos, o primeiro grupo temático trata-se da percepção das gestantes quanto às vias de parto, o segundo refere-se à relação profissional enfermeiro e gestante nas consultas de pré-natal e por fim o terceiro grupo temático abrangerá quais os sentimentos expressados pelas gestantes referentes à decisão sobre a via de parto. Conclusão: Diante da análise do objeto estudado as gestantes não possuíam um conhecimento fundamentado sobre as vias de partos, no conceito técnico/cientifico, além de encontrar o sentimento de medo da dor, tanto relacionado ao parto natural e/ou vaginal quanto no parto.
Thoracic intramedullary neurosarcoidosis with thoracic disc herniation: Diagnostic importance of intramedullary contrast enhancement
Authors: Beiriger Justin , Abou-Al-Shaar Hussam , Deng Hansen , Mathkour Mansour , Okonkwo David O.
Published: July 2021

Background:

Thoracic intramedullary neurosarcoidosis is an uncommon but serious manifestation of spinal cord disease. Its concomitant occurrence with thoracic disc herniation can mislead the physician into attributing neurologic and radiographic findings in the spinal cord to disc pathology rather than inflammatory disorder. Here, we present such a rare case of concomitant thoracic disc and spinal neurosarcoidosis.

Case Description:

A 37-year-old male presented with progressive right lower extremity weakness and numbness. Magnetic resonance imaging (MRI) of the thoracic spinal cord revealed a T6-T7 paracentral disc eccentric to the right with T2 signal change extending from T2 to T10 level. This prompted acquiring a contrasted MRI that also depicted intramedullary enhancement around the T6-T7 disc bulge. Computed tomography scan of the chest showed mediastinal lymphadenopathy concerning for sarcoidosis. Lymph node biopsy confirmed the diagnosis of sarcoidosis, and high-dose steroid treatment was initiated. The patient had significant symptomatic improvement with steroids with full neurological recovery and improvement of his symptoms.

Conclusion:

While stenosis from thoracic disc disease could potentially suggest a mechanical etiology for the patient’s symptoms, attention must be paid to the imaging findings as well as the degree and extent of cord signal change and intramedullary contrast enhancement. Appropriate and timely diagnosis is essential to avoid unnecessary invasive procedures.
Effects of Nano Silver Particles and Gibberellic Acid on Growth and Some Physiological Characteristics of Dalbergia Sissoo Roxb.
Authors: Swara Bahra J. , Al-barzinji Ikbal M.
Published: July 2021

Recent studies show that Nanotechnology can be effectively used to enhance the characteristics of many types of trees including forest trees.  Dalbergia Sissoo Roxb., which belongs to the Fabaceae family, is a forest tree that grows in dry land and water conservation areas. The aim of this study is to examine the effect of nano silver (NS) at (0, 30, 60 and 90 mg/L) and gibberellic acid (GA3) at (0, 50, 100 and 200 mg/L) concentrations on seed performance and subsequent growth of Dalbergia sissoo Roxb. The results reveal the enhancement of germination rate and velocity by using GA3 at 100 and 200 mg/L. NS90 treatment increased each of shoot and root fresh and dry weight, leaf area and plant height whereas GA50 treatment increased number of branches per plant and primary root length. Non-significant differences between treatments on Peroxidase enzyme activity and chlorophyll a content was observed whereas NS30 had the highest chlorophyll b and lowest total carotenoids. Shoot and root contents of some essential and non-essential elements differed between treatments. In roots, N90 treatment increased each of Cu and Mn elements, but it decreased Cl content. Although GA100 treatment increased Cl content, it decreased Mn. The paper concludes that the applications of nano-silver and GA3 on Dalbergia sissoo Roxb. have significant effects on its growth and physiological parameters.