bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengembangan Usaha Lampu Hias Pipa Mg Craft Melalui Kegiatan Pengabdian Kepada Masyarakat Universitas Prasetiya Mulya
Authors:   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Rifqi Ramadhan Achmad , Sutjiadi Hansen ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Anggie Hendry ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Adriel Paseru Reydia ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Yul Selly ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Katrina Sonya ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Yenchristie Stephanie ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Agustiawan Sonny ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: October 2022

Community Development is a lecture activity held by Prasetiya Mulya University for semester 5 students. On this occasion our group obtained business partners in the Wangunjaya Village, Cugenang District. Who owns the business consists of decorative lights which have raw materials consisting of paralon pipes made of PVC (Polyvinyl Chloride). Starting from the operational aspects, financial, human resources to marketing. The target that our group have discussed is to expand the scope of this business, so thatthe number of people who know this product and its development can increase significantly. In terms of operations, our partner have been able to produce up to 100 products per month after occupying a new place. Before he moved to the new place, our partner was only able to produce 50 products per month. For finance, our partner use Value-Based Pricing strategies to determine the selling price of each product. In addition, we also managed to increase our partner's monthly income from Rp 2.375.000,-to Rp 4.257.300,-. Then, for the marketing department, our group had suggested our partner to uses social media like Instagram to market our products.Instagram is used to promote existing products, while more information about products and special orders can be done via WhatsApp. And for the human resources section, our partners managed to increase the number of employees from 2 employees to 5 employees.
Faktor-Faktor yang Mempengaruhi Konsumen dalam Pembelian Jajanan Tahu Walik di Kota Cianjur
Authors:   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Augustian Billy , Nadya Jesica Camila ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Enrico Clavens ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Nasri Kimberly ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Wahyu Utami Nabilah ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Hoetama Pedro ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Widjaja Samuel ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Marchalina Leonis ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: October 2022

As time goes, Small Medium Enterprise (SME) has grown so fast, especially at Cianjur. Culinary is well-known as biggest contributor for the SME at Cianjur. PKM is a program that support economic growth at Cianjur, which also raise awareness and sales. There are 4 factors that elevate the SME at Cianjur, which is operation, marketing, financing, and human resource management. This research focus on marketing. This research existsto support the growth of Tahu Walik Si Montogh to become a great business. The rise of Tahu Walik Si Montogh can be achieved by choosing the right segmentation, positioning, and target, which based on consumer behaviour in Cianjur. Branding strategy for Tahu Walik Si Montogh use stimulus response approach, and persuasive communication technique thatis also based on segmentation, positioning, and target, which has been defined previously and can be the baseof marketing strategy for Tahu Walik Si Montogh. These two strategies are also supported by increasing the product diversification to attract customer in Cianjur.
MOTIVASI DAN SWADAYA MASYARAKAT PENERIMA BANTUAN STIMULAN PERUMAHAN SWADAYA
Authors:   Program Studi Agribisnis Fakultas Pertanian Universitas Muara Bungo, Jalan Pendidikan,  Sungai Binjai, Bungo, Jambi 37211 Indonesia, Asminar Asminar
Published: October 2022

Penerima bantuan program bantuan Stimulan perumahan swadaya (BSPS) harus memenuhi syarat ketentuan yang telah ditetapkan Kementerian Pekerjaan Umum dan Perumahan Rakyat, yaitu warga negara Indonesia yang sudah berkeluarga, memiliki atau menguasai tanah, belum memiliki rumah atau memiliki dan menempati rumah satu-satunya dengan kondisi tidak layak huni, belum pernah memperoleh bantuan stimulan perumahan swadaya dari pemerintah pusat, berepenghasilan paling banyak senilai upah minimum provinsi setempat, dan paling diutamakan masyarakat yang mauuntuk berswadaya sampai rumah yang di bangun menjadi rumah yang layak huni.Tujuan dari pengabdian ini adalah untuk mengetahui motivasi dan swadaya masyarakat dalam membuat rumah layak huni di desa Tirta kencana Kecamatan rimbo Bujang kabupaten Tebo.Kegiatan ini di lakukan tangga17 bulan april sampai 30 Juli 2019 . Metode Pengabdian masyarakat yang di laksanakan adalah Penyuluhan, survey,monitoring dan evaluasi. Data yang di peroleh dari pengabdian ini di analisas secara deskripsi Kelompok penerima manfaat di desa Tirta kencana sebanyak 2 kelompok yang beranggotaka 15 orang perkelompok , jadi semua terdapat 30 orang . Data yang di gunakan adalah data primer dan data sekunder.Hasil penelitian menunjukkan bahwamotivasi masyarakarat untuk mengikuti program bantuan stimulan perumahan swadaya (BSPS) sangat tinggi dan swdaya masyarakat banyak sehingga bisa membuat rumah layak huni hanya dengan dana Rp. 17.500.000 , ukuran rumah yang buat mayoritas lebih dari 6X6M
INOVASI PENGOLAHAN IKAN BERBASIS VARIASI PRODUK FOOD SECURITYBAGI NELAYAN TELUK KECAMATAN LABUANKABUPATEN PANDEGLANG PROVINSI BANTEN
Authors:   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Fauzi Ahmad
Published: October 2022

Studi pendahuluan yang dilakukan diperoleh informasi bahwa permasalahan yang dihadapi oleh Masalah umum yang muncul pada masyarakat kelompok usaha pengolahan ikan yaitu terbatasnya pengetahuan produksi olahan ikan, rancang bangun, dan manajemen dalam hal pengolahan variasi makanan ikan, seperti: ikan asin, ikan pindang, otak-otak. Hasil pengamatan langsung (20 Agustus 2018), usaha pengolahan ikan sudah ditekuni turun-temurun dari keluarga dimana hasil penjualan mengalami penurunan dari tahun ke tahun dikarenakan perubahan iklim cuaca dan belum adanya teknologi yang mendukung untuk menunjang produksi variasi makanan. Oleh karena itu diperlukan pengetahuan produksi olahan ikan, rancang bangun, dan manajemen pengelolaan wirausaha, sehingga pengolahan ikan lebih maksimal. Metode pendekatan yang digunakan dalam kegiatan PKM adalah pertama pendampingan yang dilakukan melalui sosialisasi dan FGD untuk memberikan pemahaman tentang potensi sumber daya alam berupa ikan yang melimpah dihasilkan oleh nelayan desa teluk yang bisa dimanfaatkan atau diolah menjadi berbagai macam makanan dan kerajinan tangan. Kedua kegiatan pelatihan pengolahan ikan berbasis food security menjadi makanan dan kerajinan tangan yang diajarkan praktek mengenai pengoalahan ikan menjadi makanan berupa nugget, bakso, sosis, empek-empek, dan otak-otak sedangkan pengolahan ikan menjadi kerajinan tangan berupa bunga hias dan perhiasan imitasi serta pelatihan mengenai manajemen keuangan sederhana. Luaran yang akan dicapai dari kegiatan ini adalah meningkatkan pengetahuan dan keterampilan penerima manfaat dalam mengolah ikan menjadi beberapa jenis produk yang bernilai sehingga dapat membantu dalam perekonomian keluarga. Serta produk dari ikan yang dihasilkan berupa makanan dan kerajinan tangan.
PENINGKATAN PROFESIONALISME GURU DALAM PENYUSUNAN LAPORAN KEUANGAN PERUSAHAAN MANUFAKTUR DENGAN MENGGUNAKAN METODE DRILL AND PRACTICE
Authors:   Akuntansi, Fakultas EkonomiUniversitas Negeri Padang, Fitria Sari Vita , Afriyenti Mayar ,   Akuntansi, Fakultas Ekonomi Universitas Negeri Padang, Elsa Betavia Ade ,   Akuntansi, Fakultas Ekonomi Universitas Negeri Padang
Published: October 2022

Pada tanggal 7 Juni 2018 telah diterbitkan Peraturan Direktur Jenderal Pendidikan Dasar dan Menengah Nomor 07/D.D5/KK 2018 tentang Struktur Kurikulum Sekolah Menengah Kejuruan (SMK)/ Madrasah Aliyah Kejurusan (MAK) sebagai bentuk revisi terbaru dari Struktur Kurikulum 2013. Sejak diterbitkannya revisi atas K13 telah membawa banyak perubahan dalam struktur kurikulum SMK kejuruan bisnis dan manajemen dengan jurusan akuntansi dan lembaga keuangan. Salah satunya adalah munculnya mata pelajaran “praktikum akuntansi jasa, dagang dan manufaktur” yang diajarkan pada kelas XI dan XII. Permasalahan yang dihadapi oleh tim MGMP Akuntansi Provinsi Sumatera Barat adalah materi akuntansi manufaktur yang merupakan bagian dari mata pelajaran “praktikum akuntansi jasa, dagang dan manufaktur” adalah hal baru sehingga membutuhkan peningkatan pemahaman dalam materi akuntansi manufaktur terutama praktek penyusunan laporan keuangan perusahaan manufaktur sebagai bentuk peningkatan profesionalisme guru dalam mengajarkan materi ini terutama untuk siswa kelas XII tahun ajaran 2019/2020. Tim pelaksana meyakini bahwa metode drill and practiceadalah metode yang paling tepat digunakan sebagai metode pembelajaran untuk mata pelajaran “praktikum akuntansi manufaktur”. Kegiatan ini dilaksanakan melalui dua pendekatan yakni capacity buildingyang memfokuskan pada konsep penting penyusunan laporan keuangan perusahaan manufaktur dan workshopyang menggunakan modul komprehensif sebagai praktik pembelajaran dengan metode drill and practice. Pada akhir kegiatan peserta dapat memahami 81.26% konsep penting penyusunan laporan keuangan manufakturdan mampu menyelesaikan 65.00% kasus penyusunan laporan keuangan manufaktur. Sehingga dapat disimpulkan bahwa kegiatan ini telah dapat meningkatkan profesionalisme guru dalam mengajar mata pelajaran “praktikum akuntansi manufaktur”
PENGGALIAN POTENSI USAHA BUMK HENDRO MULYO, LAMPUNG TENGAH
Authors:   Politeknik Keuangan Negara STAN, Kurnianingsih Puji , Fadila Syuja Andika ,   Politeknik Keuangan Negara STAN, Adi Fahrizal ,   Politeknik Keuangan Negara STAN, Ulfah Prihandini Nabilla ,   Politeknik Keuangan Negara STAN, Kurniawan Reza ,   Politeknik Keuangan Negara STAN, Permita Sari Saraswati ,   Politeknik Keuangan Negara STAN, Raharjo Taufik ,   Politeknik Keuangan Negara STAN, Sunarya Sulaeman Agus ,   Politeknik Keuangan Negara STAN
Published: October 2022

Badan Usaha Milik Kampung (BUMK) Hendro Mulyo didirikan oleh Pemerintah Kampung Tempuran, Kecamatan Trimurjo, Kabupaten Lampung Tengah. Meskipun letaknya strategis namun BUMk ini belum dapat menggali potensi usaha yang sesuai dengan kondisi masyarakat setempat. Tujuan kegiatan pengabdian masyarakat ini adalah menggali potensi desa sebagai bentuk usaha BUMK dan membuat Rencana Anggaran Biaya untuk usaha BUMK.Hasilkegiatan pengabdian kepada masyarakat iniadalah pengelolan BUMK telah menetapkan bentuk usaha dan mampu Rencana Anggaran Biayausaha mereka
Optimization of installation and energy costs in water distribution systems with unknown flow directions
Authors: Cassiolato Gustavo H. B. , Carvalho Esdras P. , Ravagnani Mauro Antonio da Silva Sá
Published: October 2022

Water distribution networks (WDNs) are an important part of water distribution systems and are responsible for water transportation from the reservoirs to the demand nodes at adequate pressure and velocity. In the present paper, the synthesis of WDN is treated as an optimization problem with a mixed integer nonlinear programming formulation. The objective function to be minimized is the total network cost, considering installation and energy costs, with unknown flow directions, which is the novelty in the paper. Disjunctive programming and linearization techniques are used in the model formulation to avoid nonlinear and nonconvex problems. Two case studies are used to test the model's applicability. Results show that operational costs can represent a significant part of the total cost in sustainable networks. In the first case study, the total cost was better than the literature results (US$ 2,272,538.85 vs. US$ 2,272,387.49) and the operational costs represent ¼ of the total WDN costs. In the second case study, the operation cost corresponds to almost 2/3 of the total WDN cost. These results show the importance of considering operational costs in the WDN design. Also, the consideration of unknown flow directions can lead to better results for the network topology.
Identification of suitable sites for traditional pokhari water harvesting in mountain rural communities of the Himalaya
Authors: Forzini Eleonora , Piemontese Luigi , Bresci Elena , Barthod Blandine , Bielser Florian , Sylvestre Marc , Adhikari Nirmal , Pun Sony , Castelli Giulio
Published: October 2022

Storing runoff during the monsoon season in Himalayan hills is crucial to have enough water to cope with the dry season, especially considering that climate change is changing rainfall intensity and patterns. Traditional Nepalese water ponds, called pokharis, are used to store runoff mainly for cattle rearing and rice fields' supplementary irrigation. Local communities are interested in restoring existing pokharis and building new ones to improve their economical and living conditions. Selecting the most suitable locations for pokharis is of crucial importance; however, scarce information is available for large-scale site selection. A comprehensive analysis of multiple relevant parameters for traditional ponds siting can lead to more efficient rainwater collection and provide a useful water resource management tool. In this work, we propose a methodology for pokharis’ best-siting analysis, based on geographic information system (GIS), multi-criteria decision-making (MCDM), and participatory research. To our knowledge, this is the first large-scale best-siting analysis for traditional ponds in Nepal. An area of 0.423 km2 (3.47% of the study area) is classified as highly suitable, with 100% agreement with existing pokharis. Despite the low data resolution, which requires a further field inspection for the final site selection, our results provide reliable guidance for pokharis’ large-scale suitability, supporting water-resilience projects in the area.
Effect of peracetic acid–ultraviolet combination treatment on microbial and endotoxin levels in a pharmaceutical water system
Authors: Farjami Afsaneh , Eradati Shiva , Hamishehkar Hamed , Siahi-Shadbad Mohammadreza , LotfiPour Farzaneh
Published: October 2022

In the pharmaceutical industry, the microbiological quality of water is vital. This research investigated how combining peracetic acid (0.1% V/V) and UV light (>150 mJ/cm2) as wide-spectrum disinfectants affect microbial and endotoxin levels in a pharmaceutical water system. Water samples were taken aseptically from 12 points across the system. The pour plate technique and membrane filtration were used for microbial counts. The presence of endotoxin in distilled water samples was investigated by the Limulus amebocyte lysate (LAL) test gel-clot method. After peracetic acid–UV combination treatment, microbial counts of samples significantly decreased (P < 0.05) compared with UV treatment alone, and they were lower than the action limits specified by the European Pharmacopeia (100 CFU/ml for purified water and 10 CFU/100 ml for water for injection). In addition, water samples were mainly LAL-negative (10 negative weekly reports out of 12 total reports). It is concluded that disinfection of all stages of the water system with peracetic acid–UV combination remarkably improved the microbial quality of the water system. Therefore, rotation between more than one disinfectant policy and periodic disinfection of the water system by peracetic acid–UV combination is recommended to minimize contamination of the water system and pharmaceutical products as well as bacterial infections in product consumers.
Study on the environmental efficiency of agricultural water resources about typical cropping patterns around the Dongting Lake area
Authors: Yang Yumei , Deng Zhenghua , Lu Xianming , Gao Xiaoling
Published: October 2022

This paper aims to evaluate the environmental efficiency of agricultural water resources utilization in different cropping patterns in the Dongting Lake area. To achieve that, the following materials are used: (1) study area: 16 counties (cities and districts) of Yueyang, Changde, and Yiyang around the Dongting Lake area; (2) data: relevant indicators of economic and environmental benefits of agricultural water resources utilization from 2011 to 2020; and (3) model: the Luenberger productivity model based on the directional distance function. With all the materials above, this paper calculates the environmental efficiency of typical cropping patterns in the Dongting Lake ecological zone and explores the spatial and temporal evolution patterns of typical cropping patterns in the lake area. The results show that (1) the environmental efficiency (LEI) of four typical cropping patterns in 16 counties (cities and districts) around Dongting Lake shows an overall increasing trend from 2011 to 2020, especially the environmental efficiency of four cropping patterns has increased significantly since 2014. (2) Among the four typical cropping patterns, the environmental efficiency of one-season rice + lobster is higher, and the environmental efficiency value of two-season rice + winter leisure is lower but most significantly improved. (3) The environmental efficiency of agricultural water resources in the hilly areas around the lake is higher than that in the Dongting Plain. Finally, some countermeasures and suggestions were put forward, such as implementing the reduction and efficiency of pesticide and chemical fertilizer in the planting industry in the lake area, optimizing the rice + planting mode, strengthening the construction of water conservation projects in the four river basins, and promoting high-standard farmland water-saving irrigation.
A role for water markets in enhancing water security in the western United States?: Lessons from the Walker River Basin
Authors: Koebele Elizabeth A. , Singletary Loretta , Hockaday Shelby E. , Ormerod Kerri Jean
Published: October 2022

In many semi-arid, snow-fed river systems, climate change is shifting the timing and quantity of streamflow; at the same time, changing water use priorities are introducing additional demands on water supplies. These dynamics challenge water security across the globe. Water markets – economic instruments used to reallocate water via voluntary trade – may be used to adapt to these changes, though their implementation remains limited. To understand how water markets may enhance water security in the western United States, we assess diverse actors’ perceptions of water allocation institutions broadly, as well as their preferences for different water market designs, in the empirical context of the Walker River Basin. This 4,200-square mile watershed, located on the California-Nevada border, exemplifies many key regional water management challenges. Through an analysis of 30 in-depth interviews, we find that actors across sectors desire changes to traditional water allocation institutions, preferably at the local level, and view markets as an acceptable tool for reallocation. Despite identified legal and social challenges, markets that facilitate temporary water trading are generally preferred. While limited to the context of a single basin, these findings provide lessons for designing water markets to enhance water security in basins regionally and beyond.
Looking for SARS-CoV-2 Therapeutics Through Computational
Approaches
Authors: Vincenzi Marian , Mercurio Flavia Anna , Leone Marilisa
Published: October 2022

Background:

In the last few years, in silico tools, including drug repurposing
coupled with structure-based virtual screening, have been extensively employed to look
for anti-COVID-19 agents.

Objective:

The present review aims to provide readers with a portrayal of computational
approaches that could be conducted more quickly and cheaply to novel anti-viral agents.
Particular attention is given to docking-based virtual screening.

Methods:

The World Health Organization website was consulted to gain the latest information
on SARS-CoV-2, its novel variants and their interplay with COVID-19 severity
and treatment options. The Protein Data Bank was explored to look for 3D coordinates of
SARS-CoV-2 proteins in their free and bound states, in the wild-types and mutated forms.
Recent literature related to in silico studies focused on SARS-CoV-2 proteins was
searched through PubMed.

Results:

A large amount of work has been devoted thus far to computationally targeting
viral entry and searching for inhibitors of the S-protein/ACE2 receptor complex. Another
large area of investigation is linked to in silico identification of molecules able to block
viral proteases -including Mpro- thus avoiding maturation of proteins crucial for virus life
cycle. Such computational studies have explored the inhibitory potential of the most diverse
molecule databases (including plant extracts, dietary compounds, FDA approved
drugs).

Conclusion:

More efforts need to be dedicated in the close future to experimentally validate
the therapeutic power of in silico identified compounds in order to catch, among the
wide ensemble of computational hits, novel therapeutics to prevent and/or treat COVID-
19.
A Glance at the Phytochemical and Ethno-pharmacological Understanding
of Four Ocimum Species
Authors: Jahanger Mohammad Abdullah , Patra Kamal Kant , Kumari Sweta , Singh Arpit , Manika N. , Srivastava Ravi Prakash , Saxena Gauri , Singh Lav
Published: October 2022

The genus Ocimum comprises many species widely cultivated in different parts of the
world for their pharmaceutical, neutraceutical and other commercial importance. Many biological
activities such as antimicrobial, cytotoxic, anti-nociceptive, anti-inflammatory, hypoglycaemic, hepatoprotective
and antioxidant have been ascribed to Ocimum, which can be linked to the occurrence of
biologically active phytochemicals like phenolic acids, essential oil, flavonoids, and terpenes hence
making it a potential source for discovery and development of novel drugs. The present review covers
the successive advances in the traditional medicinal aspects, phytochemistry, bioactivities and the
bioavailability of four Ocimum species, i.e., Ocimum basilicum L., Ocimum sanctum L., Ocimum
gratissimum L. and Ocimum tenuiflorum L., to explore their applications in versatile industries. Furthermore,
this thorough compilation will be used as a potential resource for further Ocimum-related
medication development and research and to identify the research gaps to fill.
Could Postbiotics Substitute Probiotics?
Authors: Homayouni-Rad Aziz , Pouraga Bahare , Abbasi Amin , Soleimani Roya Abedi
Published: October 2022

In recent years, the field of probiotics and postbiotics has attracted great attention. On
the one hand, probiotics, when administered in adequate amounts, confer a range of health benefits
on the host, but concerns have been reported about the administration of live microorganisms
and their associated risks. On the other hand, postbiotics with desirable traits as inactivated microbial
cells or cell fractions could non-cytotoxically benefit the consumer when ingested in sufficient
amounts. In this study, the authors have discussed the protentional of postbiotics as safe
alternatives to live probiotic microbes in functional foods, nutraceuticals, and pharmaceutical
products.
Current Landscape and Emerging Opportunities of Gene Therapy with
Non-viral Episomal Vectors
Authors: Khan Safir Ullah , Khan Munir Ullah , Khan Muhammad Imran , Kalsoom Fadia , Zahra Aqeela
Published: October 2022

Gene therapy has proven to be extremely beneficial in the management of a wide range of
genetic disorders for which there are currently no or few effective treatments. Gene transfer vectors
are very significant in the field of gene therapy. It is possible to attach a non-viral attachment vector to
the donor cell chromosome instead of integrating it, eliminating the negative consequences of both viral
and integrated vectors. It is a safe and optimal express vector for gene therapy because it does not
cause any adverse effects. However, the modest cloning rate, low expression, and low clone number
make it unsuitable for use in gene therapy. Since the first generation of non-viral attachment episomal
vectors was constructed, various steps have been taken to regulate their expression and stability, such
as truncating the MAR element, lowering the amount of CpG motifs, choosing appropriate promoters
and utilizing regulatory elements. This increases the transfection effectiveness of the non-viral attachment
vector while also causing it to express at a high level and maintain a high level of stability. A
vector is a genetic construct commonly employed in gene therapy to treat various systemic disorders.
This article examines the progress made in the development of various optimization tactics for nonviral
attachment vectors and the future applications of these vectors in gene therapy.
Targeting Gut Dysbiosis and Microbiome Metabolites for the Development
of Therapeutic Modalities for Neurological Disorders
Authors: Wiefels Matthew D. , Furar Emily , Eshraghi Rebecca S. , Mittal Jeenu , Memis Idil , Moosa Moeed , Mittal Rahul , Eshraghi Adrien A.
Published: October 2022

The gut microbiota, composed of numerous species of microbes, works in synergy with the
various organ systems in the body to bolster our overall health and well-being. The most well-known
function of the gut microbiome is to facilitate the metabolism and absorption of crucial nutrients, such
as complex carbohydrates, while also generating vitamins. In addition, the gut microbiome plays a
crucial role in regulating the functioning of the central nervous system (CNS). Host genetics, including
specific genes and single nucleotide polymorphisms (SNPs), have been implicated in the pathophysiology
of neurological disorders, including Parkinson’s disease (PD), Alzheimer’s disease (AD), and
autism spectrum disorder (ASD). The gut microbiome dysbiosis also plays a role in the pathogenesis
of these neurodegenerative disorders, thus perturbing the gut-brain axis. Overproduction of certain metabolites
synthesized by the gut microbiome, such as short-chain fatty acids (SCFAs) and p-cresyl sulfate,
are known to interfere with microglial function and trigger misfolding of alpha-synuclein protein,
which can build up inside neurons and cause damage. By determining the association of the gut microbiome
and its metabolites with various diseases, such as neurological disorders, future research will
pave the way for the development of effective preventive and treatment modalities.
Efficacy and Safety of Direct Oral Anticoagulants in the Treatment of Left
Ventricular Thrombus After Acute Anterior Myocardial Infarction in
Patients Who Underwent Percutaneous Coronary Intervention
Authors: Liang Jing , Wang Zhijian , Zhou Yujie , Shen Hua , Chai Meng , Ma Xiaoteng , Han Hongya , Shao Qiaoyu , Li Qiuxuan
Published: October 2022

Aims:

To explore treatment with direct oral anticoagulants (DOACs) in left ventricular
thrombus (LVT) after ST-segment elevation myocardial infarction (STEMI) in patients who underwent
percutaneous coronary intervention (PCI).

Background:

Contemporary data regarding using DOACs for LVT after STEMI patients who underwent
PCI is limited.

Objectives:

To investigate the efficacy and safety of DOACs on the treatment of LVT post STEMI and
PCI.

Methods:

This retrospective study enrolled patients with LVT post STEMI and PCI within 1month from
onset who received warfarin or DOACs at discharge. The primary endpoint was LVT resolution. Secondary
endpoints were major adverse cardiovascular events (MACEs), including death, stroke, systemic
embolism (SE), myocardial infarction (MI) and major or minor bleeding.

Results:

A total of 128 consecutive patients were recruited, of which 72 received warfarin and 56 DOACs
[48 on rivaroxaban and 8 on dabigatran]. The rate of LVT resolution was higher within 1 month in
the DOACs group than warfarin (26.8% vs. 11.1%; p = 0.022) (Kaplan-Meier estimates, p = 0.002). No
significant differences were found at 3 months (p = 0.246), 6 months (p = 0.201), 9 months (p = 0.171)
and 12 months (p = 0.442). No patients treated with DOACs had major bleeding, while two patients
with warfarin had upper gastrointestinal bleeding (0 vs. 2 (2.8%); p = 0.209). No death or SE occurred.
No significant differences on secondary endpoints were found in both the groups, including stroke, MI,
minor bleeding and all bleeding events.

Conclusions:

DOACs appear to be a suitable alternative to warfarin for the management of LVT post
STEMI, especially in patients who are intolerant to warfarin.
Synthesis, Antifungal Evaluation of 3-[{(1-aminomethyl) -5,7-dimethyl-2- oxoindolin-3-ylidene} amino]-2-phenylquinazolin-4(3H)-ones and their NLO, MESP, Global Reactivity Descriptor, and AIM Study through DFT Approach
Authors: Jaiswal Reena , Rastogi Nisheeth , Chaudhary Aniruddh Prasad , Srivastava Sudhir Kumar , Kant Padam
Published: October 2022

A series of fused 3-[{(1-aminomethyl)-5,7-dimethyl-2-oxoindolin-3-ylidene}amino]-2- phenylquinazolin-4(3H)-ones 4(i-ix)) has been designed and synthesized by the condensation reaction between 3-amino -2-phenylquinazolin-4(3H)-one and 5,7-dimethylindolin-2,3-dione, followed by aminomethylation with secondary amines in the presence of formaldehyde and were also screened for their antifungal potential against human pathogenic fungi. The structures of all synthesized compounds have been established with the help of elemental and spectral analysis, such as NMR, FT-IR and mass spectrometry. Out of all synthesized compounds 4(i-ix), theoretical calculation was performed for 3-((5,7-dimethyl-1-(morpholinomethyl)-2-oxoindolin-3-ylidene)amino)-2-phenylquinazolin- 4(3H)-one (4i). The experimental 1H was compared with theoretically calculated values by using B3LYP/6-31G (d, p) level through the GIAO approach. The higher value of first-order hyper polarizability predicted (4i) may be used as NLO material. To explore molecular stability, three intermolecular interactions, such as N8—O22··· H47, C37—H64 ···N12, and C23—H45 ···C30, were observed through the QTAIM approach. In addition, global reactivity descriptor and molecular electrostatic potential were computed for the prediction of reactivity and reactive sites.
Synthetic Strategies for Quinoline Based Derivatives as Potential Bioactive
Heterocycles
Authors: Sharma Shivangi , Singh Kuldeep , Singh Shivendra
Published: October 2022

Quinoline derivatives are an important class of heterocyclic compounds and possess various
applications in synthetic organic chemistry, medicinal chemistry, material chemistry and natural
product chemistry. This review article describes the different quinoline derivatives having antimalarial,
analgesic, anti-inflammatory, antineoplastic, antibacterial, antifungal, antiviral, anthelmintic,
antiprotozoal, cardiovascular, CNS and other useful bioactivities. We have delineated the general
synthetic routes for the synthesis of many bioactive quinoline based heterocycles. In addition to
this, we have also discussed the crucial synthetic routes as well as their mechanistic paths for the
formation of bioactive quinoline derivatives. The study shows that substitution at the 4 and 8-
position of quinoline is more crucial for bioactivity as compared to other positions.
Characteristics of Enzymatic Hydrolysis of Protein from Different Food
Sources and Potential Separation Techniques
Authors: Mohammad Siraj Salman , da Silva Ferreira Marcus Vinicius , Barbosa Maria Ivone Martins Jacintho , Junior José Lucena Barbosa
Published: October 2022

Enzymatic hydrolysis (EH) of proteins relies essentially upon enhancing the functional
and nutritional properties of proteins, such as antioxidant activity, solubility, oil holding capacity,
water holding capacity, emulsification, foaming properties, and sensory properties. There
is a big challenge for protein separation and purification due to the high production cost, the
large number of amino acids, and the complex biological system of proteins. These biological
structures are always presented in a multi-component mixture in native environments, which are
usually similar to other molecular weights of other components, such as protein-lipid complexes.
These difficulties present the importance of a combination of the hydrolysis process of protein
with adequate technology for separation and purification to achieve better bioactive peptide recovery.
There are many studies conducted dealing with the characteristics of the hydrolysis process
of proteins, and other implications, such as the separation of protein and bioactive peptides.
Therefore, this study aims to review the important and recent research papers that investigated
the effect of various conditions of the enzymatic hydrolysis process (EHP) (type of enzyme, enzyme
to substrate ratio, temperature, pH, and time) on the antioxidant capacity of protein hydrolysates
and degree of hydrolysis, as well as to assess the recent studies about protein purification
and potential separation techniques.
Medicinal Plants, Economical and Natural Agents with Antioxidant Activity
Authors: Shahrajabian Mohamad Hesam , Sun Wenli
Published: October 2022

Over the past few decades, the multifaceted anticancer action of various plant-derived flavonoids has been demonstrated both in in vitro and in vivo preclinical experiments as well as in clinical trials and large-scale epidemiological studies. These secondary metabolites, synthesized in plants in response to different environmental stresses, can exert diverse biological activities in the human body after ingestion of plant-based foods. Flavonoids are indeed well-known for their antioxidant, anti-inflammatory, antiproliferative, proapoptotic, anti-migratory, antiinvasive, anti-metastatic, and anti-angiogenic properties, thereby preventing and slowing the development of different types of human cancers. Accordingly, more and more people all over the world have increased their everyday intake of fruits, vegetables, whole grains, and spices to get the benefits of flavonoids. In this commentary article, a critical view is presented on the possible gradual decrease in the health-promoting effects of edible and medicinal plant products related to changes in their flavonoid content and composition as a consequence of global warming. It is indeed generally accepted that biosynthesis and accumulation of certain flavonoids can be higher in plants cultivated in colder conditions, while a high temperature may even block the production of these agents. It only remains to be determined in the future as to what extent the lowering of flavonoids content in plant-based diets during global warming can contribute to continuously increasing worldwide incidence of new cancer cases, revealing the actual costs of human-induced environmental changes.

:

Important traditional medicinal plants with antioxidant activities in China are Asparagus, bindii, blueberries, barberry fruit, borage, calendula, camellia, coriander, cumin, Chinese bayberry, bitter Chinese melon, Chinese cabbage, Chinese cherry, Chinese jujube, Chinese olive, pomegranate, Chinese rose tea, Chinese toon, Chinese watermelon, black tea, green tea, knotweed, Chinese quince, Chinese rhubarb, pomegranate, sumac, thyme, wolfberry, dendrobium, drumstick tree, rosemary, black Zira, rose, Fiscus species, ginger, ginkgo, goji berry, grape, Jerusalem thorn, jujube, kiwifruit seed oil, and liquorice root.

:

The main derived exogenous natural antioxidants are derived from medicinal plants, fruits, foods, flowers, and traditional herbal medicines. Among various medicinal plants, the medicinal plants common in Asian traditional medicine have shown enormous potential as great sources of natural antioxidants. Polyphenols, and some other secondary bioactive compounds like anthocyanins, isoflavones, pterostilbene, resveratol, quercetin and catechins have shown potent antioxidant activity.
Simultaneous Determination of Two Potential Genotoxic Impurities in
L-Malic Acid by Liquid Chromatography-Tandem Mass Spectrometry
Authors: Zhao Zhen Xiong , Pang Jia Qian , Zhang Ling Ling , Xu Yu Bin , Fan Qing
Published: October 2022

Background:

Genotoxic impurities (GTIs) are produced during the synthesis of active
pharmaceutical ingredients and pharmaceutical excipients. L-malic acid, an important active pharmaceutical
ingredient and excipient, is widely used in the pharmaceutical industry. However, the detection
of potential GTIs in L-malic acid has not been reported.

Objective:

This study aims to establish a rapid and sensitive liquid chromatography-tandem mass
spectrometry (LC-MS/MS) method to determine the concentration of potential GTIs in L-malic acid,
including N-nitroso-aspartic (NASP) and 2-chlorosuccinic acid (CSA).

Methods:

In this work, GTIs were separated by a reverse-phase Accucore C18 column (100 mm × 2.1
mm, 2.6 μm), with gradient elution using methanol and 0.05% ammonia. The multiple reaction monitoring
(MRM) negative mode was used to detect GTIs, with transitional ion pairs of m/z from 131.6 to
88.0 for NASP, and from 150.9 to 70.9 for CSA.

Results:

The limit of detections (LODs) of NASP and CSA were 2 ng/mL (0.02 ppm) and 5 ng/mL
(0.05 ppm), respectively. Both the limit of quantifications (LOQs) of NASP and CSA were 20 ng /mL
(0.2 ppm). Good linearity of calibration curves in the concentration ranging from 10 to 500 ng/mL
was obtained. The precision was less than 5%, and the intermediate precision was less than 10%. The
accuracy ranged from 95.4% to 102.4%, with a relative standard deviation (RSD) of less than 5%. Also,
the solution's stability and robustness were acceptable.

Conclusion:

Compliant with requirements from (International Council for Harmonization) ICH
guidelines, this method can be used for routine analysis and stability studies for GTIs’ levels in pharmaceutical
quality control.
A Bright Horizon of Intelligent Targeted-cancer Therapy: Nanoparticles
Against Breast Cancer Stem Cells
Authors: Vaez Ahmad , Abbasi Milad , Shabani Leili , Azizipour Esmat , Shafiee Mostafa , Zare Mohammad Ali , Rahbar Omid , Azari Arezo , Amani Ali Mohammad , Golchin Ali
Published: October 2022

Breast cancer stem cells (BCSCs) are heterogeneous tumor-initiating cell subgroups of breast
cancers that possess some stem cell markers and are sustained after chemotherapy. Due to BCSCs being
sufficient for tumor relapse, and given that the biological behaviors of BCSCs are so complex, it is critical
to figure out exactly how they work, learn more about their cell biology, and discover biomarkers and
strategies for explicitly targeting and destructing cancer stem cells. In order to accomplish innovative
treatment for breast cancer, it is also essential to target BCSCs. Despite the vast quantities of BCSC target
chemicals, their therapeutic implementation is limited due to off-target behavior and bioavailability issues.
Targeted drug delivery systems based on nanoparticles have advantages for transporting anti-BCSC
materials, especially to targeted locations. Hence, breast cancer therapy using a nanoparticle-based
BCSCs targeting system is a promising strategy. Such targeted drug delivery systems can resolve the
biodistribution obstacles of nanosystems. Throughout this paper, we highlight various strategies for targeting
BCSCs utilizing nano-based systems. In conclusion, issues about the inadequate stability of nanoparticles
and the possibility of loaded drug leakage during delivery systems have yet to be answered.
More fundamental and applied research, and proper methods such as coating or surface modification are
required.
Isoniazid Derivatives as Anti-Tubercular Agents: From Structural Design
to Clinical Investigations
Authors: Rishanlang Nongkhlaw , Ridahunlang Nongkhlaw , Bisht Rohit
Published: October 2022

Background:

Tuberculosis (TB) is one of the fatal infectious diseases, making it one of the
causes of death in the infectious mortality strata, and it is of prime concern globally. It is spread by a
causative agent called Mycobacterium tuberculosis (Mtb) which gets ingressed within the host cells.
The current clinical interventions have been associated with various limitations, such as a long treatment
regimen (6 months), low lipophilicity of drugs to penetrate the bacterial cell, associated side effects
and emerging incidence of multiple drug-resistant strains. Despite these limitations, Isoniazid
(INH), a first-line agent, remains a drug of choice to date due to its effectiveness. However, INH is
associated with poor penetration into the bacteria cell wall and ultimately leads to the low therapeutic
distribution of drugs into the lungs.

Methods:

Studies have shown that the structural modifications of INH by introducing more lipophilic
moiety could lead to its better penetration into the bacterial cell wall resulting in better anti-TB activities.

Results:

This review updates various studies conducted on INH derivatives as anti-tubercular (Anti-TB)
agents, including in silico and preclinical investigations. In addition, updates on clinical investigations
of novel anti-TB molecules have also been highlighted.

Conclusion:

The article focuses on the structural modification of various INH derivatives reported,
including the in vitro studies and molecular modelling preclinical and clinical investigations of various
INH derivatives.
Effects of GABAergic Agents on Multiple Sclerosis. A Narrative Review of In-vivo Models
Authors: Stamoula Еleni , Ainatzoglou Alexandra , Dardalas Ioannis , Vavilis Theofanis , Stamatellos Vasileios-Periklis , Siafis Spyridon , Psathas Thomas , Boskou Ioanna , Papazisis Georgios
Published: October 2022

Background:

Multiple sclerosis (MS) is a lifelong deteriorating disease characterized by
multiple heterogeneous symptoms. Being an autoimmune disease of the central nervous system, mainly
affecting the myelin sheath of the nerves ordinarily results in neurological symptoms. GABA has
numerous effects on the immune cells, altering cytokine production, cell migration and proliferation.
Immune cells express GABA receptors making GABA an inflammation modulator. Therefore, GABAergic-
associated agents could provide a compatible add-on therapy for MS patients alleviating their
symptoms and providing better quality years.

Objective:

This review aims to highlight and provide evidence of the potential benefits of a secondary
treatment option in MS patients, aiming to better manage this disease.

Methods:

We conducted a literature search through PubMed, Scopus and Google Scholar for GABA
agonists, antagonists and modulators used in the in vivo model of experimental autoimmune encephalomyelitis
(EAE), taking into consideration certain inclusion and exclusion criteria.

Results:

In vivo studies for GABA-a and GABA-b agonists and modulators showed regulation of the
autoimmune response in EAE mice. Increased preservation of myelinated sensitive fibers and diminished
axonal damage in the CNS was also demonstrated. Further, decreased mononuclear inflammatory
infiltration, pro-inflammatory cytokines reduction and reduced levels of Reactive oxygen species
(ROS) were also reported. Biological results included decreased peak disease severity, duration, clinical
scores and EAE incidence in the treatment groups.

Conclusion:

GABA agonists and modulators efficiently challenged different aspects of disease pathophysiology
in vivo models of EAE. The studies showed a significant relevance of neuroprotection via
modulation of the autoimmune response in EAE rats, indicating that they should be considered proper
therapeutic candidates for clinical use, while also further clinical studies could empower their administration
in clinical practice.
Modernization of a Traditional Siddha Medicine Paccai eruvai into a Novel Nanogel Formulation for the Potent Wound Healing Activity-A Phyto- Pharmaceutical Approach
Authors: Yoganandam Gnanakumar Prakash , Sakthiganapathi Meenachisundaram , Gopal Venkatachalam
Published: October 2022

Background:

Paccai eruvai formulation has been widely used in traditional Siddha practice to treat ulcerous wounds due to the content of potentially active compounds.

Objective:

The present study aimed to determine the enhancement potency of wound healing of nanogels containing Paccai eruvai in an incision and excision wound models.

Methods:

Paccai eruvai nanogel was synthesized using the high-energy milling method, and characterization and enhancement of the wound healing potential of Paccai eruvai nanogel were assessed.

Results:

Reportedly, Paccai eruvai nanogel has been produced successfully and its chemical properties confirmed, and physical properties characterized. Paccai eruvai nanogel showed homogeneity, green color, transparency, and an average size of 19.73 nm. We observed a significant reduction of wound area (p<0.001) in the Paccai eruvai nanogel-treated rats. The percentage of wound contraction on the 16th day was higher than the traditional formulation and nitrofurazone treatment. Notably, a lesser epithelialization period (14.33 days) and higher hydroxyproline content were observed in the 10% Paccai eruvai nanogel rats. We found that 10 % Paccai eruvai nanogel treatment increased tensile strength suggesting a better therapeutic indication.

Conclusion:

The present findings indicate that Paccai eruvai nanogel significantly contributes wound healing activities with the enhancement of collagen synthesis, wound contraction, and wound tensile strength.