bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and Characterization of Lipid Nanoparticles Loaded with
Antipsychotic Drugs using Central Composite Design
Authors: Patel Ayushi D. , Modi Chetna D. , Thakkar Vaishali T. , Rana Hardik B. , Chavda Dipika D.
Published: November 2023

Background:

Fluoxetine and olanzapine combination tablets are available in the
market for oral administration in the treatment of depression, but fluoxetine has been shown to
have a dose-related side effect due to its high oral dose and ability to undergo excessive first-pass
metabolism. Olanzapine has low solubility and low bioavailability.

Objective:

The objective of this study was to prepare lipid nanoparticles containing fluoxetine
and olanzapine to enhance the solubility and dissolution profile of the drugs.

Methods:

Lipid nanoparticles (LNs) were prepared by high-speed homogenization using the ultrasonication method. Different lipids and surfactants were used to screen out the best lipids, surfactants, and their ratio in the preparation of lipid nanoparticles. Drug and polymer compatibil-ity was examined using FTIR and DSC studies. The formulation was optimized using the central composite design to establish functional relationship between independent variables and respons-es. Optimized batch was characterized using particle size, PDI, zeta potential, % EE, % CDR, and stability.

Results:

Phase solubility study revealed FLX to have highest solubility in stearic acid and oleic
acid, whereas OLZ showed highest solubility in Precirol ATO 5 and oleic acid. Poloxamer 188
was selected on the basis of high entrapment efficiency of the drug. In LNs, no significant
interaction between drug and polymer was confirmed by DSC and FTIR. The particle size of
optimized batch was found to be 411.5 nm with 0.532 PDI and - 9.24 mV zeta potential. For FLX
and OLZ, the %EE and %CDR after 8h were found to be more than 90%. No significant change
in %EE and %CDR of the formulation was observed after 4 weeks of storage.

Conclusion:

Experimental results demonstrated excellent drug entrapment as well as controlled
release behavior from optimized LNs of FLX and OLZ at reduced dosage frequency.
Prosopopeia Como Orto-Doxia Estética e Retórica: Literariedade e Eficácia do Discurso da Publicidade
Authors: Barroso Paulo
Published: November 2023

O discurso publicitário é peculiar, tem as funções apelativas e persuasivas da linguagem e objetivos genéricos: chamar a atenção, suscitar interesse, provocar desejo e levar à ação de compra e consumo. Quer se apresente na forma verbal (texto) quer na forma não verbal (imagem), a linguagem da publicidade concilia duas vertentes fundamentais: a estética, porque é essencialmente literária, ficcional, poética, emotiva e sedutora; a retórica, porque é pragmática, eficaz e persuasiva. Estas vertentes devem-se ao recurso a frequentes e diversificadas figuras de retórica, em particular as que estabelecem analogias, pois implicam identidades e estabelecem comparações. É o caso da prosopopeia, figura de retórica frequente e eficaz em publicidade, por ser simples de estabelecer implicações e de as entender e por potenciar o discurso, tornando-o mais vivaz, atrativo, empático e identificando os produtos/marcas e os consumidores. Como a linguagem publicitária se torna estética e retórica com a prosopopeia? Como a prosopopeia estabelece o sentido e orienta o entendimento da significação das mensagens publicitárias? Através de uma abordagem teórico-conceptual, este artigo apresenta um estudo qualitativo centrado na aplicação da prosopopeia como recurso estilístico e retórico no discurso publicitário. Os objetivos são: (a) relacionar as duas vertentes mencionadas (a estética e a retórica) na atratividade das estratégias persuasivas em comunicação publicitária, e (b) justificar a prosopopeia como potência da orto-doxia do discurso literário da publicidade.
Strengths and Weaknesses of ChatGPT Models for Scientific Writing About Medical Vitamin B12: Mixed Methods Study (Preprint)
Authors: Abuyaman Omar
Published: November 2023

BACKGROUND

ChatGPT is a large language model developed by OpenAI designed to generate human-like responses to prompts.

OBJECTIVE

This study aims to evaluate the ability of GPT-4 to generate scientific content and assist in scientific writing using medical vitamin B12 as the topic. Furthermore, the study will compare the performance of GPT-4 to its predecessor, GPT-3.5.

METHODS

The study examined responses from GPT-4 and GPT-3.5 to vitamin B12–related prompts, focusing on their quality and characteristics and comparing them to established scientific literature.

RESULTS

The results indicated that GPT-4 can potentially streamline scientific writing through its ability to edit language and write abstracts, keywords, and abbreviation lists. However, significant limitations of ChatGPT were revealed, including its inability to identify and address bias, inability to include recent information, lack of transparency, and inclusion of inaccurate information. Additionally, it cannot check for plagiarism or provide proper references. The accuracy of GPT-4’s answers was found to be superior to GPT-3.5.

CONCLUSIONS

ChatGPT can be considered a helpful assistant in the writing process but not a replacement for a scientist’s expertise. Researchers must remain aware of its limitations and use it appropriately. The improvements in consecutive ChatGPT versions suggest the possibility of overcoming some present limitations in the near future.
Telemedicine-Based Risk Program to Prevent Falls Among Older Adults: Protocol for a Randomized Quality Improvement Trial (Preprint)
Authors: Rein David B , Hackney Madeleine E , Haddad Yara K , Sublett Farah A , Moreland Briana , Imhof Laurie , Peterson Cora , Legha Jaswinder K , Mark Janice , Vaughan Camille P , Johnson II Theodore M , Bergen Gwen ,   Emory STEADI Implementation team
Published: November 2023

BACKGROUND

The Center for Disease Control and Prevention’s Stopping Elderly Accidents, Deaths, and Injuries (STEADI) initiative offers health care providers tools and resources to assist with fall risk screening and multifactorial fall risk assessment and interventions. Its effectiveness has never been evaluated in a randomized trial.

OBJECTIVE

This study aims to describe the protocol for the STEADI Options Randomized Quality Improvement Trial (RQIT), which was designed to evaluate the impact on falls and all-cause health expenditures of a telemedicine-based form of STEADI implemented among older adults aged 65 years and older, within a primary care setting.

METHODS

STEADI Options was a pragmatic RQIT implemented within a health system comparing a telemedicine version of the STEADI fall risk assessment to the standard of care (SOC). Before screening, we randomized all eligible patients in participating clinics into the STEADI arm or SOC arm based on their scheduled provider. All received the Stay Independent screener (SIS) to determine fall risk. Patients were considered at risk for falls if they scored 4 or more on the SIS or answered affirmatively to any 1 of the 3 key questions within the SIS. Patients screened at risk for falls and randomized to the STEADI arm were offered a registered nurse (RN)–led STEADI assessment through telemedicine; the RN provided assessment results and recommendations to the providers, who were advised to discuss fall-prevention strategies with their patients. Patients screened at risk for falls and randomized to the SOC arm were asked to participate in study data collection only. Data on recruitment, STEADI assessments, use of recommended prevention services, medications, and fall occurrences were collected using electronic health records and patient surveys. Using staff time diaries and administrative records, the study prospectively collected data on STEADI implementation costs and all-cause outpatient and inpatient charges incurred over the year following enrollment.

RESULTS

The study enrolled 720 patients (n=307, 42.6% STEADI arm; n=353, 49% SOC arm; and n=60, 8.3% discontinued arm) from September 2020 to December 2021. Follow-up data collection was completed in January 2023. As of February 2024, data analysis is complete, and results are expected to be published by the end of 2025.

CONCLUSIONS

The STEADI RQIT evaluates the impact of a telemedicine-based, STEADI-based fall risk assessment on falls and all-cause health expenditures and can provide information on the intervention’s effectiveness and cost-effectiveness.

CLINICALTRIAL

ClinicalTrials.gov NCT05390736, http://clinicaltrials.gov/ct2/show/NCT05390736

INTERNATIONAL REGISTERED REPORT

RR1-10.2196/54395
Family-Based WhatsApp Intervention to Promote Healthy Eating Behaviors Among Amazonian School Children: Protocol for a Randomized Controlled Trial (Preprint)
Authors: Hovadick Ana Carolina de Andrade , Cardoso Marly Augusto
Published: November 2023

BACKGROUND

Stunting and micronutrient deficiencies have persistently affected children in the Brazilian Amazon for decades. However, in recent years, a notable increase in childhood overweight prevalence has been observed, particularly in the context of heightened food insecurity exacerbated by the COVID-19 pandemic. Despite the limited number of effective solutions proposed to tackle this problem, digital interventions have shown great promise worldwide in preventing obesity and promoting healthy diets.

OBJECTIVE

This study aims to describe the protocol of a family-based WhatsApp intervention, specifically designed to investigate the efficacy of multimedia messaging in preventing excessive weight gain and improving healthy eating practices among school-aged children in the Amazon region.

METHODS

This study protocol outlines a theory-driven randomized controlled trial based on the cognitive theory of multimedia learning and the social cognitive theory. A total of 240 parents or caregivers of children enrolled in the Maternal and Child Health and Nutrition Cohort Study in Acre (MINA-Brazil) will be recruited by phone and social media. The intervention group will receive persuasive multimedia messages through WhatsApp over 19 weeks, while the waitlist control group will remain in the usual care. The primary outcome is a change in children’s BMI in z score. Secondary outcomes are changes in dietary intake and biochemical indicators of the children. Outcome measures will be assessed at baseline and 5 months after randomization in comparison to usual care. The analysis will use an intent-to-treat approach and will be conducted using the statistical package Stata (version 18.0), with a significance level set at P<.05. Paired and unpaired 2-tailed t tests will be applied to compare mean changes in the outcomes.

RESULTS

Data collection started in June 2023, and final measurements are scheduled to be completed in December 2023. The results of the main analysis are expected to be available in 2024.

CONCLUSIONS

This innovative multimedia message intervention holds significant potential for fostering behavioral changes among Amazonian children.

CLINICALTRIAL

Brazilian Clinical Trials Registry RBR-5zdnw6t; https://ensaiosclinicos.gov.br/rg/RBR-5zdnw6t

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/54446
South African legislation pertinent to building practice: A review in the context of inherent dolomite land hazard
Authors: Ngubelanga S. , Rooy J.L. Van
Published: November 2023

Dolomite land occurs across five of the nine South Africa provinces and its vast occurrence and distribution makes it difficult to avoid when planning for building projects. Such terrains are generally associated with the formation of ground instability events (sinkholes & subsidences) causing widespread damage to infrastructure or loss of life. Under section 24 of the Constitution of South Africa, (Act 108 of 1996), safe environment and protection thereof has been elevated to a basic human right. In the context of safe land use planning and sustainable infrastructure development, more particularly post-1994, a series of statutes have been promulgated to provide a legislated framework for building practice in South Africa. The National Building Regulations and Building Standards (Act 103 of 1977) as amended, and the current National Building Regulations (NBR’s), have been promulgated to promote uniformity in the law relating to the erection of buildings in South Africa including prioritizing safe land for human settlement. A key principles is that if conditions of the land on which a building was or is being or is to be erected, shows signs of becoming dangerous to property and/ or life, such conditions must be investigated and secured. However, there seem to be challenges in the practical implementation. This paper therefore presents a review into the legislation pertinent to building practice to identify possible gaps, implementation challenges and damaging effects due to inappropriate development of dolomite land. The research further scrutinizes an influence or lack thereof, of the technical requirements aimed at ensuring sustainable development on geologically hazard prone terrains.
Potencial impacto multisectorial manufacturero del nearshoring en los estados de la frontera norte de México: un enfoque de insumo producto
Authors: Gaytán Alfaro Edgar David , Martínez Hernández Junior Alfredo
Published: November 2023

La presente investigación tiene como objetivo central evaluar un conjunto de impactos multisectoriales derivados del proceso de relocalización de firmas en México bajo una lógica de propagación de efectos empleando una metodología de campo de influencia. Considerando los escenarios prospectados por el Banco Interamericano de Desarrollo (BID), la Comisión Económica para América Latina (CEPAL) y el Banco de México (BANXICO), se evalúa el impacto en las exportaciones y, como consecuencia de ello, se extienden implicaciones al conjunto del aparato productivo a lo largo de los seis estados de la frontera norte de México. El alcance de tal objetivo requirió la construcción de las matrices regionales de insumo producto de dichas entidades federativas, así como la adaptación de éstas a los vectores de exportaciones por estados publicados por el Instituto Nacional de Estadística y Geografía (INEGI). Los resultados muestran la proyección de un crecimiento concentrado sectorialmente, así como poco significativo en el fortalecimiento a las cadenas de valor de demanda intermedia. No obstante, acorde a los mismos, el nearshoring, reunirá cualidades de incidencia en la variación relativa en la demanda agregada cuyo impacto se desagrega sectorial y territorialmente como una aportación del presente estudio.
Road Damage Detection and Classification
Authors: Kasar Mr. Swacchand
Published: November 2023

Abstract: This is a road damage detection desktop application. In the subject of transportation engineering, identifying road damage early on is essential because it can save maintenance costs and avoid accidents. Deep learning methods have demonstrated encouraging performance in a number of computer vision tasks recently, including the detection of road damage. In this study, we suggest a region-based convolutional neural network (R-CNN)-based method for detecting road degradation. Using a publicly accessible dataset of road photos with different kinds of damage, such as cracks, potholes, and patches, we trained our R-CNN. Our approach outperformed cutting-edge techniques with an accuracy of 85% in identifying road damage.
A Review Paper on Sentiment Analysis using Machine Learning
Authors: Vishwakarma Shweta
Published: November 2023

Abstract: Opinion Mining (OM) or Sentiment Analysis (SA) can be described as the process of identifying, extracting, and categorizing viewpoints on various subjects. It falls under the domain of natural language processing (NLP) and is commonly employed to gauge public sentiment towards specific laws, policies, marketing campaigns, and more. This involves the development of methodologies to collect and analyze comments and opinions posted on social media platforms concerning legislation, regulations, and other related matters. Information extraction plays a pivotal role in this process, as it is both challenging and invaluable. Therefore, the utilization of automated opinion-mining techniques becomes imperative for extracting sentiments from various online sources. Presently, several methods are employed, including machine learning (both supervised and unsupervised), lexical-based approaches, and sentiment analysis. This study aims to comprehensively examine the methodologies employed in sentiment analysis (SA) and opinion mining (OM), two interrelated yet distinct techniques. Additionally, it delves into the domains of sentiment analysis applications and the associated challenges, building upon previous research efforts in the field. In this review paper different sentiment analysis techniques have been discussed.
Kualitas Media Pembelajaran Digital Mahasiswa PGSD
Authors: Dian Fitri Nur Aini  , Kumalasani Maharani Putri , Kusumaningtyas Dian Ika
Published: November 2023

The COVID-19 pandemic, which has persisted for two years, has significantly impacted various sectors, including learning-related education. However, along with the decline in COVID-19 cases, the government has provided recommendations and the freedom for learning to be carried out with limited face-to-face meetings. One of the essential learning tools to support online and offline learning is digital learning media. Teachers and prospective teachers can develop digital learning media with four aspects, namely content, learning design, learning media and communication, as well as implementation power and user response. The aim of this study is to provide an in-depth description of the quality of content aspects, learning design and the construct of digital learning media for PGSD (Primary School Teacher Education) students. This research employed a qualitative research design. The research model used in this study is a descriptive model describing the quality of digital learning media developed by PGSD students. It was conducted at the University of Muhammadiyah Malang and the University of Borneo. The subjects in this study were UMM PGSD and Borneo University PGSD students. The instruments used in this study were observation guidelines, questionnaires, assessment instruments and interviews. The average quality of the content aspect reached 86%, the learning design aspect reached 83%, and the construct aspect reached 85%, all three of which showed outstanding results. The existence of digital learning media that has excellent quality in the teaching and learning process will increase students' learning motivation.
Kemampuan Literasi Budaya dan Kewargaan Mahasiswa PGSD Universitas Muhamadiyah Sidoarjo, Indonesia
Authors: Kurniawan Machful Indra
Published: November 2023

Cultural and civic literacy is part of the national literacy movement launched by the Ministry of Education and Culture in Indonesia. This initiative seeks to equip all Indonesian citizens with the essential skills to navigate and respond to the increasing diversity of the 21st century. The Primary School Teacher Education (PGSD) study program at University Muhammadiyah Sidoarjo (UMSIDA) recognizes the importance of this goal. It provides material content for learning about cultural and civic issues. Based on this, it is essential to conduct research on the cultural literacy and citizenship abilities of PGSD students at Universitas Muhammadiyah Sidoarjo in the 21st century to know the cultural literacy and citizenship abilities of students and provide references to further learning activities in developing cultural literacy and citizenship in PGSD students. The research was conducted in the 2021/2022 academic year, which is between February 2022 and June 2022. This research employed a descriptive study using the survey method with a sample of 136 semester II students who have taken civics courses. Data collection techniques were in the form of questionnaires and data analysis techniques using percentage techniques. The study results showed that the percentage shows 68.4%, namely, out of 136 students, 93 students have a relatively high range of scores in digital literacy skills and citizenship.
Principles of Listening in The Quran and Their Development in Islamic Preaching: A Study of Surah Al-Nahl/16:78
Authors: Fauziah Mira
Published: November 2023

The Quran mentions that humans are endowed with a sense of hearing, yet they fail to utilize it to listen to the verses and guidance of Allah. This work aims to examine the principles of listening in the Quran and their development in Islamic preaching. This study employs content analysis to comprehend the significance of hearing Surah Al-Nahl/16:78. The research findings reveal that through the utilization of the sense of hearing, individuals acquire knowledge, leading them to obey all of Allah's commands and prohibitions. The sense of hearing is highly effective when employed to listen to preaching materials via videos on various social media platforms.
Study on The Nurul Quran Method at The Syakirin Center of Al-Qur’an Education
Authors: Wahid Abd. , Mahmud Nursyahindah Binti , Asnawiyah Asnawiyah , Nazaryani Nazaryani
Published: November 2023

Every believer is obligated to possess the ability to read the Quran proficiently. This obligation extends not only to adults but is also encouraged from a young age, ensuring that children learn the sacred verses of the Quran. The significance of this mandate is earnestly acknowledged by the Youth Department of the Pan-Malaysian Islamic Party (PAS), which has established several renowned Quranic Education Centers throughout Malaysia. These educational centers have received widespread recognition and are considered pioneers in the establishment of Quranic Education Centers (TPA). Over the past half-century since its inception, TPA has continued to evolve, employing a teaching methodology known as the "Nurul Quran Method." This article aims to assess the effectiveness of the Nurul Quran Method in the Quranic learning process at TPA Syakirin. Additionally, the article explores the challenges faced by teachers and administrators at TPA Syakirin in their efforts to enhance students' abilities within the institution. This study adopts a qualitative approach, utilizing methods such as observation, interviews, and documentation for data collection. The research findings indicate that the learning process using the Nurul Quran Method proceeds smoothly. This method incorporates elements of "learning through play" and various other creative techniques. One of the key strengths of TPA Syakirin lies in its utilization of a distinctive teaching methodology, not only in Malaysia but also from Quranic education institutions in other countries across Southeast Asia.
The First Saint Petersburg Regional Inflammatory Bowel Diseases Registry on the Basis of the Regional Health Information System: Principles of Functioning, Testing Results, Plan of Development
Authors: Uspenskiy Yu. P. , Sarana A. M. , Melentyeva L. N. , Yazenok A. V. , Petrov S. V. , Fominykh Yu. A. , Ivanov S. V. , Shotik A. V. , Segal A. M. , Gorbacheva T. V. , Plotnikova S. D. , Dronov K. V.
Published: November 2023

Aim: to present the principles of functioning of the regional registry of inflammatory bowel disease (IBD) patients in Saint Petersburg on the basis of the City Health Information System (Saint Petersburg IBD Registry).

Key points. The Saint Petersburg IBD Registry consists of General Statistical Module and Clinical Module. The General Statistical Module is intended to analyze the prevalence of ulcerative colitis and Crohn's disease, the number of patient visits to medical institutions; to assess the burden on the healthcare system, demographic characteristics, routing and mortality for the whole region. The Clinical Module allows to assess the IBD features in prospective observation. The register case report form is integrated into the patient's status in the Medical Information System of the medical institution. Saint Petersburg IBD Registry operates on the basis of the Saint Petersburg Medical Center of Information and Analysis within the framework of the Regional Medical Data Collection System of the Russian state information system “Regional Fragment of the Unified State Information System in the Healthcare Branch”. The accumulation of prospective data in the Clinical Module continues, which in the near future will make it possible to test and configure the automated analytical block of the registry.

Conclusion. The functioning of the Saint Petersburg IBD Registry allows to achieve following primary goals within region: assessment of the epidemiological features of IBD in Saint Petersburg; dynamic assessment of the disease features; assessment and planning of health care resources required to provide care to IBD patients; improvement of approaches to the treatment taking into account the specifics of the region; assessment of the effectiveness and tolerability of specific treatment including biologics.
GENDER INEQUALITY IN WOMEN'S ACCESS TO ENVIRONMENTAL RESOURCES
Authors: Ariyani Linda , Wardina Miza , Herawati Leni , Aggraini Dinda Putri , Mukti Ichrar Syahbani
Published: November 2023

Gender inequality is an issue that has long been debated in various fields, including women's access to environmental resources. This research was conducted by conducting a literature review of articles, journals, and other relevant publications. The literature review method was used to collect and analyze information from previous researchers on Gender Inequality in Women's Access and Environmental Resources. Based on some of these research references, it can be concluded that gender inequality in women's access to environmental resources is a real issue in various contexts. Measures to improve gender equality in access to environmental resources include strengthening the role of women in decision-making, social change, and inclusive policies and a gender-based approach in environmental program planning and implementation. Collective efforts from the government, civil society, and the private sector are needed to overcome gender inequality and achieve sustainable development that is just and sustainable.
Charles J. Adam's Framework for the Study of Religion
Authors: Shobirin Abdurrahman , Aziz Ahmad Fakhril , Abdurochman Hikmat , Fadhlan Muhammad
Published: November 2023

Charles J. Adams' concern about methods and approaches to the study of Islam is an academic concern about the failure of historians of religion to expand our knowledge and understanding of Islam as a religion, and experts on Islam (Islamists) to explain precisely the phenomenon of Islamic religiosity. To answer this academic anxiety, Charles J. Adam uses two disciplines, namely the history of religion and Islamic studies as a theoretical framework or framework (conceptual tool). To analyze the two disciplines, he uses two approaches, namely a normative or religious approach and a descriptive approach. The scope of his study consists of the study of Pre-Islamic Arabia, the Study of the Life of the Prophet Muhammad, the Study of the Qur'an, the Study of Hadith, the Study of Kalam Science, the Study of Sufism, the Study of the Shi'a School, Popular Religion, the Study of Worship, the Study of Philosophy, and the Study of Islamic Law. The major contribution of Adams' thought is to provide a distance between the normative approach that has a religious commitment in conducting research and the descriptive approach that has no religious commitment. The study of his thoughts on Islam has received some criticism and support. Among them is M. Amin Abdullah, who thinks that Charles J. Adams' thinking produces an understanding of Historicity-Profanity and Interconnectedness.
Evaluating the Works of Indonesian Star-chitects, Case Studies: Star-chitects building designs in Indonesia
Authors: Salura Purnama , Fauzy Bachtiar , Clarissa Stephanie , Lake Reginaldo Christophori
Published: November 2023

Towards the 20th century, in the world of architectural practice, there was an expression to refer to famous architect experts, "star-architect", or simply "star-chitect". The work of these star-chitects is widely published and used as a reference for designing new architectural works. However, it is very rare for academic research to focus on examining the architectural works of these star-chitects, even though these architectural works may not necessarily perform well and be able to positively benefit the surrounding environment. Therefore, this study aims to explore in depth the works of Indonesian star-chitects, particularly related to two main aspects of architecture, namely aspects of function and form. In line with this objective, the research not only examines the literature that is in line with the research issue but also integrates the interpretations of architects, users and observers. An analysis will be carried out on the work of Indonesian star-chitects that accommodate different functions, namely residential, hotel, library, and religious building. This research formulates a conceptual framework for analyzing architectural works based on the basic needs of architecture, which consist of architectural purpose-function-use. Its application to reading architecture in case studies shows that it shows that star-chitect architecture does not always perform well when evaluated based on theory and empirical conditions. In addition to contributing to the development of architectural knowledge, this research also brings practitioners to the awareness of the importance of a harmonious relationship between the function and form of architecture, as well as giving insights and providing alternative perspectives for laymen in appreciating architectural works.
TLM Analysis of Metal Contacts for 2D MoS2 Nanoflakes Deposited by Chemical Vapour Deposition-free technique
Authors: Zakaria Rozalina , Long Tan Chee
Published: November 2023

In the past decade, two-dimensional (2D) nanomaterials are gaining significant attention due to their novel properties in electrical, optical, mechanical which are different from their bulk forms. Therefore, it becomes one of the most promising materials for sensing applications. However, to connect the 3D world with 2D materials require excellent communication links which is a contact that renders remarkable electrical properties and specifically 2D nanomaterials-based sensor has been suffering from high resistance and low sensitivity due to the loss caused by poor contact between the 2D nanomaterials and metal interface. This work explores the electrical properties of metal/2D contacts by the rectangular transmission line method (TLM). The critical resistance parameters such as sheet and specific contact resistance were determined by characterizing the current-voltage (IV) relation. The behavior of different metals (silver and gold) contacts to 2D MoS2 nanoflakes deposited on Si substrate by low-cost spray coating technique are observed. These metals are chosen based on the work function relative to the electron’s affinity, χ of MoS2. UV-Vis’s analysis is carried out to estimate the final concentration of MoS2 solution.
Upaya peningkatan motivasi siswa dalam melanjutkan studi ke jenjang perguruan tinggi di Desa Langkaplancar Kabupaten Pangandaran
Authors: Abidin Jenal
Published: November 2023

Seiring perkembangan zaman, peran pendidikan di perguruan tinggi sangatlah penting untuk menyiapkan siswa menjadi pribadi yang memiliki kemampuan untuk bisa mengembangkan dirinya lebih maju lagi. Berdasarkan hasil dari survey lapangan data siswa yang melanjutkan pendididikan keperguruan tinggi di desa langkaplancar masih kurang, serta motivasi mereka untuk melajutkan ke jenjang perguruan tinggi masih rendah. Kenyataannya saat ini di Desa Langkaplancar banyak lulusan SMA/sederajat yang memutuskan untuk tidak meneruskan pendidikan ke Perguruan Tinggi, ada yang memilih untuk bekerja atau bahkan menganggur karena faktor ekonomi dan kurangnya motivasi melanjutkan. Salahsatu ikhtiar yang dilakukan untuk menyelesaikan permasalahan ini adalah diadakannya kegiatan Seminar Education Motivation Traning. Tujuan kegiatan ini adalah untuk meningkatkan motivasi siswa untuk melanjutkan kejenjang yang lebih tinggi atau ke perguruan tinggi dan untuk menumbuhkan kesadaran semua pihak khususnya orangtua dalam memberikan dukungan terhadap anak (siswa/siswi) agar melanjutkan ke jenjang yang lebih tinggi atau perguruan tinggi.Kata Kunci : Seminar, Motivasi, Pendidikan
Perencanaan pendampingan mutu lembaga PKBM di Kota Cimahi
Authors: Sukmana Cucu , Lutfiansyah Dadang Yunus , Purnomo Purnomo , Sulistiono Eko
Published: November 2023

Tujuan dari penelitian ini adalah untuk mendeskripsikan dan menganalisis pengelolaan PKBM Ash-Shoddiq Desa Pagerwangi Kecamatan Lembang Kabupaten Bandung Barat. Penelitian ini dilakukan dengan menggunakan metode penelitian deskriptif dengan pendekatan kualitatif. Pendekatan kualitatif sendiri menitikberatkan pada item-item yang mengandung makna subjektif dan definitif serta deskripsi penelitian berdasarkan skema dan pemikiran peneliti. Sumber data penelitian ini adalah tiga sumber yang terdiri dari sumber informasi yaitu ketua dan pemilik PKBM yaitu Dadang Lutfiansyah, M.Pd. Serta dua orang di sekitar PKBM yang bisa memberikan data. Untuk meningkatkan pengumpulan data lapangan, peneliti menggunakan teknik observasi, wawancara, dan dokumentasi secara online dan pada bulan April 2021 dengan akses langsung ke penjaga objek penelitian dan media sosial objek penelitian. dan menggunakan teknik sampling yang ditargetkan. Hasil penelitian menunjukkan data yang diperoleh terkait dengan Pengelolaan PKBM meliputi tahapan pengelolaan yang meliputi langkah-langkah sebagai berikut Perencanaan, Pengorganisasian, Pelaksanaan (Motivating), Pembinaan (Comforming), Penilaian (Evaluating), Pengembangan (Developing). Permasalahan PKBM adalah kurangnya sarana prasarana dan sarana (ruang kelas yang kurang, ruang kelas, tenaga pengajar, area site yang kecil). Hal ini dikarenakan keterbatasan dana dan tidak sebanding dengan letak fasilitas PKBM. Di tengah kawasan wisata yang sibuk. Ini dikunjungi oleh wisatawan domestik dan mancanegara
Penyuluhan perkembangan dan tantangan peserta didik usia pendidikan dasar pada Abad 21
Authors: Acesta Arrofa
Published: November 2023

Pendidikan yang mampu mendukung pembangunan di masa mendatang adalah pendidikan yang mampu mengembangkan potensi setiap peserta didik. Untuk dapat mengembangkan potensi peserta didik guru harus memahami perkembangan peserta didik. Hal ini disebabkan karena setiap tahapan perkembangan manusia mempunyai karakteristik yang khas dan tugas-tugas perkembangan tersendiri. Tugas-tugas perkembangan tersebut juga sangat berhubungan dengan seberapa jauh pendidikan yang dapat diterima oleh individu. Melihat hal ini maka sangatlah penting pelaksanan pendidikan mempertimbangkan perkembangan peserta didik. Maka muncul pertanyaan apakah guru sudah memahami perkembangan peserta didik dan tantangan yang dihadapi dalam pendidikan abad 21. Berdasarkan hasil wawancara dengan Kepala Sekolah Satu Atap Cimulya diketahui bahwa sebagian besar guru masih membutuhkan pengetahuan mengenai perkembangan peserta didik dan tantangan yang dihadapi dalam pendidikan abad 21. Kondisi ini tentunya perlu ditanggapi guna meningkatkan profesionalisme guru. Hal ini yang mejadikan landasan dalam melaksanakan “Penyuluhan Perkembangan Peserta Didik Dan Tantangan Yang Dihadapi Peserta Didik Usia Pendidikan Dasar Pada Abad 21 di Sekolah Satu Atap Cimulya, Kecamatan Cimahi, Kabupaten Kuningan”. Tujuan dari pengabdian ini adalah: untuk 1)  memberikan pemahaman terhadap guru mengenai perkembangan peserta didik, 2) memberikan pengetahuan tantangan peserta didik pada usia pendidikan dasar pada pendidikan abad 21. Metode yang digunakan adalah Penyuluhan penyampaian materi(ekspositori) dan diskusi
Kata Kunci: Penyuluhan;peserta didik;abad 21.
Avaliação do perfil epidemiológico das hepatites virais no Brasil - 2010 a 2021.
Authors: Bertati Letícia Martins , Guimarães Nara Moraes , Andreolli Julia Antoniazzi , Barbosa Karine Ferreira , Salvatori Alessandra , Frias Danila Fernanda Rodrigues
Published: November 2023

O objetivo nesta pesquisa foi analisar o perfil epidemiológico das hepatites virais no Brasil, no período de 2010 a 2021. Realizou-se um estudo transversal, descritivo, retrospectivo e qualiquantitativo que utilizou como unidades de análise as unidades federativas brasileiras. Os dados foram coletados a partir das informações disponíveis no site TABNET/DATASUS, DCCI, e a estimativa da população anual absoluta foi obtida no Instituto Brasileiro de Geografia e Estatística (IBGE). No período analisado foram registrados 476.981 casos de hepatites virais no Brasil, destacando-se a notificação de casos de hepatite C, seguida pela hepatite B, A e D. Com relação a taxa de incidência, a região Norte destacou-se para hepatite A e D, e a região Sudeste para hepatite B e C. O sexo do indivíduo acometido em todos os tipos de hepatite virais analisados que se destacou foi o masculino, mas com pouca diferença do feminino. Foram registrados 25.553 óbitos, sendo 78,3% devido à hepatite C. A presente pesquisa nos permitiu concluir que o tipo de hepatite mais relatada no Brasil é a tipo C, assim como a que mais provoca óbitos. Todas as hepatites virais apresentaram queda nas notificações no ano de 2020 e 2021 e por isso este fato deve ser analisado pelos setores de vigilância pois pode se tratar de subnotificações, principalmente devido a situação do país neste período, que enfrentava a pandemia de COVID-19.
Regenerative potential and clinical application of mesenchymal stem cell-derived exosomes (review)
Authors:   Biotechnology Laboratory, Medical Company “Good Cells”, Kyiv, Ukraine, Gordiienko Inna , Shamshur Maryna ,   R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Sciences of Ukraine, Kyiv, Ukraine,   Institute of Genetic and Regenerative Medicine, M. D. Strazhesko National Scientific Center of Cardiology, Clinical and Regenerative Medicine, National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine, Novikova Svitlana , Zlatskiy Igor , Zlatska Alona
Published: November 2023

For more than 50 years, mesenchymal stem cells have been extensively studied as a therapeutic agent in the treatment of various diseases. It became clear that MSC-derived secretome including the growth factors, cytokines, microvesicles and exosomes are the major drivers in the realization of beneficial effect of MSC-based therapy. Exosomes play an important role in the organism homeostasis and diseases development working as a vehicle for the transfer of the signaling and regulatory molecules between cells. Exosomes size, stability, cargo content that reflect the physiological state of parent cells make them an attractive new tool for regenerative medicine. Cell-free therapy or cell therapy 2.0 are being developed. Here, we review the molecular profile of exosomes derived from different MSC sources and their biological properties, the results of clinical application of MSC-derived exosomes in the of treatment COVID-19, alopecia, skin aging and osteoarthritis, discuss what issues exist in the development and application of a new biomedical product. The purpose of this study was to analyze the literature data on the regenerative potential and clinical application of exosomes derived from mesenchymal stem cells. Materials and methods. An analytical review of literature data was conducted using the information analysis of Medline (PubMed), Web of Science and Scopus databases, Google Scholar and the Cochrane Central Register of Controlled Trials (CENTRAL) and other sources until 2022 inclusive using the keywords: «exosomes», «mesenchymal stem cells», «cell-free therapy», «secretome», «miRNA» Results. In this review, we consider the molecular profile of exosomes derived from different MSC sources and their biological properties, the results of clinical application of MSC-derived exosomes in the treatment of COVID-19, alopecia, skin aging and osteoarthritis, discuss what issues exist in the development and application of a new biomedical product. Conclusion. The study, research and development of biotechnological products based on exosomes from different stem cell types are new stages in the development of regenerative medicine. Understanding the unique biological properties of MSCs derived from various tissue sources is one of the keys to develop effective exosomes-based biotechnological products to address specific medical goals.
Trauma History and Course of Therapy in a Naturalistic Cognitive Behavior Therapy Outpatient Sample: An Archive Data Study
Authors: Epe-Jungeblodt Franziska , Pauli Paul , Schwab Frank , Andreatta Marta
Published: November 2023

Objective: Cognitive Behavior Therapy (CBT) is an effective treatment
for anxiety and depression disorders. Nonetheless, nearly 50% of all
patients do not respond. Besides other factors, this seems to be linked
to the experience of traumatic life events. This study aims to assess
the effects of trauma history on the choice of therapy interventions and
treatment outcomes. Methods: We analyzed data from 340 CBT outpatients
diagnosed with a depression or anxiety disorder and possibly a trauma
history treated under naturalistic conditions. Based on their written
therapy files, we collected information on trauma history, psychiatric
diagnoses, duration of therapy, applied interventions, and severity of
depression and anxiety symptoms at the start and end of therapy. The
influence of trauma, diagnoses, and intervention use on the development
of depression and anxiety symptoms were analyzed. Results: Patients with
a trauma history reported higher overall depression and anxiety symptoms
than those without trauma. No differences in the duration of therapy,
applied interventions, or decrease in symptom severity were found
between patients with and without a trauma history. Trauma-specific
interventions failed to boost treatment success; however, they were also
seldom applied. Conclusion: Although no differences between traumatized
and non-traumatized patients were found for naturalistic CBT,
traumatized patients maintained higher levels of symptom severity
irrespective of diagnoses. These results indicate a need for more
trauma-specific and personalized interventions. Therapists may need
evidence-based guidelines to personalize CBT for patients with a trauma
history and high symptom severity.
Lung Ultrasound Findings in Children with Asthma Exacerbations
Authors: Hoffmann Robert M. , Neuman Mark , Du Michelle , Monuteaux Michael , Miller Andrew F. , Neal Jeffrey , Nelson Kyle , Gravel Cynthia
Published: November 2023

Objective: We sought to characterize point-of-care lung
ultrasound (LUS) findings in children with asthma exacerbations and to
determine whether the presence and magnitude of findings were associated
with asthma severity. Methods: We enrolled a convenience sample
of patients aged 5-18 years presenting with acute asthma exacerbation to
a tertiary care pediatric emergency department. Severity of an asthma
exacerbation (mild, moderate, severe) was assessed within 1-hour of the
LUS using the Hospital Asthma Severity Score, a validated asthma
assessment tool. LUS was performed by trained pediatric emergency
providers . The presence of LUS findings (any B-lines, ≥3
B-lines per view, consolidations, pleural effusion and pleural line
abnormalities) was assessed using a standardized criterion.
Results: A total of 111 patients with a median age of 8 years
(IQR 6, 12) were enrolled. LUS was positive in 57% of patients. Pleural
line abnormalities were observed in 34%, B-lines in 29%,
consolidations <1cm in 24%, and consolidations ≥1cm in 7 %.
Patients with moderate and severe asthma exacerbations were more likely
to have any B-lines (31% and 43%, respectively) than patients with
mild exacerbations (12%; p= 0.021), however the presence of ≥3 B-lines
did not differ across severity groups. The presence of other findings
did not differ based upon asthma severity. Conclusions: LUS
findings are commonly observed in patients presenting with asthma
exacerbations. While B-lines were more likely to be found in
exacerbations of higher severity, LUS findings associated with pediatric
pneumonia did not correlate with severity. These findings provide
valuable information for the diagnostic use of LUS.
Inhibition of gut digestive proteases by cyanobacterial diets decreases infection in a Daphnia host-parasite system
Authors: Sanchez Kristel , Elert Eric von , Monell Kira , Calhoun Siobhan , Maisha Aniqa , McCreadie Paige , Duffy Meghan
Published: November 2023

1. Secondary metabolites produced by primary producers have a wide range
of functions as well as indirect effects outside the scope of their
direct target. Research suggests that protease inhibitors produced by
cyanobacteria influence grazing by herbivores and may also protect
against parasites of cyanobacteria. In this study we asked whether those
same protease inhibitors produced by cyanobacteria also can influence
interactions of herbivores with their parasites. 2. We used the
Daphnia-Metschnikowia zooplankton host-fungal parasite system to address
this question because it is well documented that cyanobacteria protease
inhibitors suppress trypsin and chymotrypsin in the gut of Daphnia, and
because it is known that Metschnikowia infects via the gut. We tested
the hypothesis that Daphnia gut proteases are necessary for
Metschnikowia spores to be released from their asci. We then also tested
whether diets that decrease trypsin and chymotrypsin activity in the
guts of Daphnia lead to lower levels of infection. 3. Our results show
that chymotrypsin promotes release of the fungal spores from their asci.
Moreover, a diet that strongly inhibited chymotrypsin activity in
Daphnia decreased infection levels, particularly in the most susceptible
Daphnia clones. 4. Our results support the growing literature that
cyanobacterial diets can be beneficial to zooplankton hosts when
challenged by parasites and uncover a mechanism that contributes to the
protective effect of cyanobacterial diets. Specifically, we demonstrate
that host chymotrypsin enzymes promote dehiscence of Metschnikowia
spores; when cyanobacteria inhibit activity of chymotrypsin in hosts,
this most likely traps the spore inside the ascus, preventing the
parasite from puncturing the gut and beginning the infection process. 5.
This study illustrates how secondary metabolites of phytoplankton can
protect herbivores against their own enemies.
Comparison of two Automated Urine Analysers (UriScan Super+ YD Diagnostics and Sysmex UC-3500 -UF 5000 Urine Chemistry Analyzer) with Routine microscopy
Authors: Aden Durre , Khambra Poonam , ranga sunil
Published: November 2023

Background: Urinalysis is one of the most commonly performed
screening tests in the Clinical laboratory to diagnose and monitor
various urological and systemic conditions. Newly developed automated
urine analyzers are expected to routinely screen urine to reduce TAT and
provide clinicians with prompt clinical information with a lower
false-negative rate. The study aimed to evaluate the diagnostic
performance of the two Automated Urine analyzers and compare them with
microscopy. Method: There were 124 randomly selected samples of
patients coming to the clinical pathology laboratory were taken for each
Automated analyzer and microscopic evaluation. The results of various
cells, formed elements and microorganisms were compared between both the
automated urine analyzers and microscopy and the degree of concordance
was calculated for each parameter. Results: The degree of
concordance of RBC, WBC and epithelial cells was good between the two
automated analyzers; URiSCAN Super+ YD Diagnostics and Sysmex
UC-3500 -UF 5000 Urine Analyzer and microscopy with p <0.001.
The concordance between the Sysmex UC-3500 - UF 5000 Urine Analyzer and
manual microscopy was better than between manual microscopy and Uriscan
Super + YD Diagnostics. There was no concordance between all
these methods for either crystals, cast, bacteria and fungi with p
>0.05 Conclusion: The results from the automated
analyzers for RBCs, WBCs and epithelial cells were similar to the result
of manual microscopy and the analyzers can be relied upon. However,
bacteria, fungi, dysmorphic red cells, casts and crystals need to be
analyzed by microscopic examination before giving a final diagnosis.