bluuebunny/crossref_metadata_2025 huggingface dataset:
Pemafibrate Tends to have Better Efficacy in Treating Dyslipidemia than Fenofibrate
Authors: Wang Haizhou , Li Haiou , Zhou Yunjiao , Liu Jing , Wang Fan , Zhao Qiu
Published: November 2019

Aims:

To compare the efficacy of pemafibrate (PF) and fenofibrate (FF) in treating dyslipidemia.

Methods:

A comprehensive search was performed on the public database to identify relevant randomized controlled
trials (RCTs), which compared the effects of PF and FF treatment in lipid parameters among patients with
dyslipidemia. Mean difference (MD) and 95% confidence intervals (CI) were pooled for continuous outcomes,
whereas odds ratio (OR) and 95% CI were calculated for dichotomous outcomes.

Results:

Three RCTs were included with a total of 744 patients (PF=547 and FF=197). Compared with the FF
group (100mg/day), PF group (0.05 to 0.4mg/day) had a better effect on reducing triglycerides (TGs) (MD, -8.66;
95%CI, -10.91 to -6.41), very low-density lipoprotein cholesterol (VLDL-C, MD, -12.19; 95%CI, -15.37 to -
9.01), remnant lipoprotein cholesterol (MD, -13.16; 95%CI, -17.62 to -8.69), apolipoprotein-B48 (ApoB48, MD,
-12.74; 95%CI, -17.71 to -7.76) and ApoCIII (MD, -6.25; 95%CI, -11.85 to -0.64). Although a slightly LDL-Cincreasing
effect was found in PF-treated group (MD, 3.10; 95%CI, -0.12 to 6.09), the levels of HDL-C (MD,
3.59; 95%CI, 1.65 to 5.53) and ApoAI (MD, 1.60; 95%CI, 0.38 to 2.82) were significantly increased in the PF
group. However, no significant difference was found in the level of total cholesterol (MD, 0.01; 95%CI, -1.37 to -
1.39), non-HDL-C (MD, -0.06; 95%CI, -1.75 to 1.63), ApoB (MD, 0.39; 95%CI, -1.37 to 2.15) and ApoAII (MD,
3.31; 95%CI, -1.66 to 8.29) between the two groups. In addition, the incidence of total adverse events (OR, 0.68;
95%CI, 0.53 to 0.86) and adverse drug reactions (OR, 0.36; 95%CI, 0.24 to 0.54) was lower in the PF group than
that in the FF group.

Conclusions:

Pemafibrate tends to have better efficacy in treating dyslipidemia than fenofibrate.
Comparison of Hypoglycemic and Antioxidant Activities of the Compounds Isolated from Ficus hispida Linn. and Ficus pomifera Wall
Authors: Nepram Ashalata , Wangkheirakpam Sujata , Laitonjam Warjeet S.
Published: November 2019

Background:

Traditional knowledge has been a legacy of the past to the present. Barks of
Ficus hispida Linn. and leaves of Ficus pomifera Wall. (Moraceae) have been used traditionally for
the treatment of diabetes in North-east India and many other places. As many drugs have been developed
from traditional plants, the authors have taken up the plants for the study of hypoglycemic
activity.

Objective:

To investigate the hypoglycemic activities of the triterpenoids isolated from the plants
and their antioxidant activities.

Methods:

The bioactive compounds were determined by biochemical analysis, antioxidant activity
using DPPH method. Hypoglycemic activity was detected using glucose tolerance test in normal rats
and alloxan induced diabetic rats with Gliclazide as standard.

Results:

The biochemicals and trace elements were present in appreciable amounts. Triterpenoids,
(1-5), from F. pomifera and 19-hydroxyphlogacantholide (6), 3-O-[ß-D-glucopyranosyl-(1’→2’)-α-
L-rhamnopyranosyl-phlogacanthoside] (7) and galanolactone (8) along with stigmasterol (9), stigmasta-
5,22-dien-7-on-3ß-ol (10), 5-(decahydro-1,1,4a-trimethyl-6-methylene-5-yl)-3-methylpent-2-
enal (11), stigmasterol glucoside (12) and stigmast-4-en-3-one (13) from F. hispida Linn., respectively,
were isolated. The different extracts of the barks and leaves of these plants along with the isolated
compounds had antioxidant and hyploglycemic activities.

Conclusions:

The five triterpenoids (1-5) were isolated from the methanol extract of the leaves of F.
pomifera, and compounds (6-13) were isolated from the chloroform extract of the barks of F. hispida.
Methanol extract of the leaves of F. pomifera and the chloroform extract of the barks of F. hispida;
compounds (1-13) isolated from these two plants reduced DPPH free radicals in a concentrationdependent
manner. It was also observed that the methanol and chloroform extracts of the plants, F.
pomifera and F. hispida respectively, and the compounds (1, 6 & 7) exhibited anti-diabetic properties
and also caused a highly significant reduction in the blood glucose levels of normal rats.
Organocatalytic Regioselective [3+2] Annulation of Morita-Baylis-Hillman Carbonates with Azonaphthalenes: An Efficient Access to 3-Spiropyrazole- 2-oxindoles
Authors: Cheng Yuyu , Lu Zhongyue , Li Pengfei
Published: November 2019

Background:

A cheap and commercially available organocatalyst, 4-dimethylaminopyridine was successfully employed in the regioselective [3+2] cycloaddition of isatin-derived Morita-Baylis- Hillman carbonates with azonaphthalenes for the construction of 3-spiropyrazole-2-oxindoles in excellent yields under mild conditions.

Methods:

In the presence of 4-dimethylaminopyridine with a loading of 10 mol%, a series of isatinderived Morita-Baylis-Hillman carbonates reacted smoothly with azonaphthalenes in dichloromethane at room temperature to furnish 3-spiropyrazole-2-oxindoles in 72-98% yield.

Result and Conclusion:

In summary, we have developed reasonably cheap and commercially available 4-dimethylaminopyridine-mediated regioselective [3+2] annulations between isatin-derived Morita- Baylis-Hillman carbonates and azonaphthalenes for the construction of 3-spiropyrazole-2-oxindoles under mild conditions.
Ketamine Infusion in Post-Surgical Pain Management after Head and Neck Surgery: A Retrospective Observational Study
Authors: Pota Vincenzo , Passavanti Maria B. , Aurilio Caterina , Barbarisi Manlio , Giaccari Luca G. , Colella Umberto , Fiore Marco , Mangoni di Santostefano Giuseppe S. R. C. , Sansone Pasquale , Pace Maria C.
Published: November 2019

Background:

Head and neck cancer affects approximately 382,000 new patients per year worldwide with a significant portion undergoing surgical treatment. During postoperative period key elements in the Intensive Care Unit (ICU) are airway management and pain control.

Objective:

We evaluated the average change of inpatient pain control using a Numerical Rating Score (NRS). We also evaluated the time of extubation after ICU admission recording the incidence of desaturation and the necessity of re-intubation. Secondary outcomes were the incidence of postoperative complications, included those narcotics-related, and the use of rescue analgesics.

Methods:

In this retrospective observational study, we analyzed data of registry before and after we have changed our postoperative analgesic protocol from remifentanil infusion to ketamine infusion.

Results:

Medical records of 20 patients were examined. 10 patients received 0.5 mg/kg ketamine bolus at the end of surgery, followed by a continuous infusion of 0.25 mg/kg/h. All patients presented a significant decrease in pain intensity from the 4th to 48th postoperative hour (p < 0.05), but statically not a significant difference in NRS score was recorded between the two groups. Time to extubation was shorter in ketamine group compared to the remifentanil group (112.30 min ± 16.78 vs. 78 min ± 14.17; p < 0.05). Desaturation rate was 10% in the remifentanil group, while no case was recorded in the ketamine group.

Conclusion:

The level of analgesia provided by ketamine and remifentanil was comparable. Ketamine was superior in ventilatory management of the patient with more rapid extubation and with no case of desaturation.
Willingness to Seek Help for Depression in Young African American Adults: Study Protocol
Authors: Bamgbade Benita A , Barner Jamie C , Ford Kentya H , Brown Carolyn M , Lawson William B , Burdine Kimberly
Published: November 2019

Background

In the United States, among those living with mental illness, 81% of African American (AA) young adults do not seek treatment compared with 66% of their white counterparts. Although the literature has identified unique culturally related factors that impact help seeking among AAs, limited information exists regarding the development and evaluation of interventions that incorporate these unique factors.

Objective

This study aims to describe a study protocol designed to develop a culturally relevant, theory-based, psychoeducational intervention for AA young adults; to determine if exposure to the intervention impacts AA young adults’ willingness to seek help; and to determine whether cultural factors and stigma add to the prediction of willingness to seek help.

Methods

The Theory of Planned Behavior (TPB) and Barrera and Castro’s framework for cultural adaptation of interventions were used as guiding frameworks. In stage 1 (information gathering), a literature review and three focus groups were conducted to identify salient cultural beliefs. Using stage 1 results, the intervention was designed in stage 2 (preliminary adaptation design), and in stage 3 (preliminary adaptation tests), the intervention was tested using pretest, posttest, and 3-month follow-up surveys. An experimental, mixed methods, prospective one-group intervention design was employed, and the primary outcomes were participants’ willingness and intention to seek help for depression and actual help-seeking behavior.

Results

This study was funded in May 2016 and approved by the University of Texas at Austin institutional review board. Data were collected from November 2016 to March 2016. Of the 103 students who signed up to participate in the study, 70 (67.9%) completed the pre- and posttest surveys. The findings are expected to be submitted for publication in 2020.

Conclusions

The findings from this research are expected to improve clinical practice by providing empirical evidence as to whether a culturally relevant psychoeducational intervention is useful for improving help seeking among young AAs. It will also inform future research and intervention development involving the TPB and willingness to seek help by identifying the important factors related to willingness to seek help. Advancing this field of research may facilitate improvements in help-seeking behavior among AA young people and reduce the associated mental health disparities that apparently manifest early on.

International Registered Report Identifier (IRRID)

DERR1-10.2196/16267
Tierra, trabajo y tóxicos:
Authors: Galarza Suárez Lucía
Published: November 2019

Bananas are among the world’s most traded fruit. Yet not everyone benefits equally from the fruit’s production and consumption. This article analyzes the political, social and environmental costs of export monoculture through a historical and ethnographic reconstruction of the production of banana lands in Ecuador’s southern coastal region. This analysis centers around the practices of diverse state, business and popular actors confronted with the expansion of large scale plantations, the loss of tropical biodiversity and the incorporation of rural populations into capitalist relations of production. Drawing attention to the co-constitution of society and nature and the testimonies of those living and working in this region, this article seeks to contribute to a greater understanding of the extractivist logics and practices promoted by the territorialization of both state and capital interests in rural worlds throughout the diverse historical stages of their expansion.
Implementation of a neuron model using FPGAS
Authors: Bañuelos-Saucedo M. A. , Castillo-Hernández J. , Quintana-Thierry S. , Damián-Zamacona R. , Valeriano-Assem J. , Cervantes R. E. , Fuentes-González R. , Calva-Olmos G. , Pérez-Silva J. L.
Published: November 2019

Artificial neural networks base their processing capabilities in a parallel architecture, and this makes them useful to solve pattern recognition, system identification, and control problems. In this paper, we present a FPGA (Field Programmable Gate Array) based digital implementation of a McCulloch-Pitts type of neuron model with three types of non-linear activation function: step, ramp-saturation, and sigmoid. We present the VHDL language code used to implement the neurons as well as to present simulation results obtained with Xilinx Foundation 3.0 software. The results are analyzed in terms of speed and percentage of chip usage.
El deporte como arma de distracción masiva
Authors: Brohm Jean-Marie , Ollier Fabien
Published: November 2019

El artículo describe, desde la perspectiva de la teoría crítica del deporte, aspectos sociales de diferentes prácticas deportivas contemporáneas como la carrera, la marcha o determinados usos del ciclismo. Se revisan algunos valores positivos atribuidos al deporte, como son su supuesto carácter integrador, pacificador o de superación personal y se critican estos planteamientos esencialistas ofreciendo una lectura en negativo de la práctica deportiva. Se critica la mercantilización del deporte, su utilización política y su papel de amortiguador de la crítica y el compromiso social. Para ilustrar las tendencias anteriores, se utilizan textos de diferentes autores en la órbita de las ciencias humanas y sociales.
La perspectiva de género en sociología del deporte en España: presente y futuro
Authors: Piedra Joaquín
Published: November 2019

El interés de la sociología del deporte por la situación de las mujeres ha ido creciendo en las últimas décadas en nuestro país. La inclusión de la perspectiva de género en los estudios sociales ha permitido, no solo comprender mejor la realidad deportiva, sino también denunciar las injusticias existentes. Así, el desarrollo científico en la sociología del deporte ha conducido a una multiplicidad de líneas de estudio desde la perspectiva de género. Concretamente se han abierto y desarrollado ocho grandes líneas de análisis: medios de comunicación, socioeducativa, sociohistórica, orientación e identidad de género, deporte y corporeidad, práctica deportiva, psicología social y gestión del deporte. Estas líneas no son las únicas, pero constituyen una realidad importante y actual de la investigación en sociología del deporte en España. Líneas además que deben de enriquecerse con nuevos planteamientos y nuevas metodologías ya en uso fuera de nuestro país.
Mujeres en la ciencia contemporánea. La aguja y el camello. Ana M. González Ramos (dir.). Barcelona: Icaria, 2018
Authors: Jiménez Arroyo Sandra
Published: November 2019

La obra que aquí se reseña, titulada Mujeres en la ciencia contemporánea. La aguja y el camello, fue publicada en 2018 por la editorial Icaria en su Colección Antrazyt. Recoge gran parte de los resultados de una ambiciosa investigación llevada a cabo en el seno del Proyecto “GENERA: Generación de un economía del conocimiento más inclusiva y competitiva” (FEM 2013-48225-C3-1-R). Este fue financiado por la “Convocatoria Retos” del Ministerio de Economía y Competitividad y desarrollado durante los últimos cuatro años por un nutrido grupo interdisciplinar e interuniversitario de especialistas en género, todas ellas dirigidas con extraordinario saber hacer por la Dra. Ana M. González Ramos como investigadora principal.
La compra pública como instrumento de transferencia de conocimiento en regiones periféricas: evidencias de un estudio de caso en España
Authors: Lobera Josep , Torres-Albero Cristóbal , Díaz-Catalán Celia
Published: November 2019

Este artículo analiza la primera experiencia en España de compra pública pre-comercial aplicada a la transferencia del conocimiento. Las evidencias muestran que, más allá de los resultados obtenidos en términos de prototipos innovadores, este tipo de aplicación presenta unas características que potencialmente pueden generar cambios sustanciales en el sistema de innovación analizado. Particularmente de interés es el cambio de rol en el organismo público de investigación (CSIC), que pasa de tener funciones puramente de producción de I+D a tener capacidad de decisión en la asignación de fondos y monitorización del desarrollo de las innovaciones, transformando positivamente el ecosistema relacional. Los resultados obtenidos muestran una mayor eficacia de este instrumento respecto a otros más asentados en el tiempo.
Approaches to solving the problem of search of scenarios of lessons on informatics for basic school in the Moscow E-School library
Authors: Levchenko Irina V , Sadykova Albina R
Published: November 2019

Problem and goal. The article deals with the problem of search of scenarios of lessons on informatics for basic school in the Moscow E-School (MESH) Library. The goal is to identify the features of the MESH search engine and possible approaches to improving the process of scenarios of informatics lessons for basic school. Methodology. In the process of research was used a set of methods: analysis of the resources of the MESH library and normative documents; reﬂection of the content of knowledge obtained; searching for approaches to improving the process of ﬁnding scenarios of informatics lessons for basic schools in the MESH library; local pedagogical experiment. Results. Revealed the diﬀerence of the classiﬁcation of sections and themes of the school informatics course provided by the Approximate Basic Educational Program [16] (in accordance with General Educational Standards [20]) and the MESH library classiﬁcation [3], as well as the presence of a large number of controlled elements of MESH library content, indicated by the creators of the scenarios of lessons on informatics for basic school, what determines the problem of ﬁnding the right resources. The results of the study allowed to ﬁnd approaches to solving the identiﬁed problem. Conclusion. The approaches to solving the identiﬁed problem of search of scenarios of lessons on informatics for basic school in the MESH library are proposed, their implementation can have a positive impact on the ability to ﬁnd the necessary digital resource and, as a result, increase the eﬀectiveness of professional activity of basic school informatics teacher.
Individual Educational Programs as New Mechanism of Integration between Higher Education and Labor Sphere
Authors: Senashenko Vasiliy S , Struchkova Elena P
Published: November 2019

At present the problem of the integration between the higher education and the sphere of labor has become particularly urgent. It is noted that the attempts earlier made by a number of authors to solve the problem of the integration between the higher education and the labor sphere by combining educational and professional standards, as well as by harmonizing the requirements of the labor market for the qualiﬁcations of specialists and the competencies of graduates of higher education are facing signiﬁcant diﬃculties. In this paper, we consider individual educational programs as one of the mechanisms of combining the higher education and labor. The analysis of the emerging diﬀerences between the higher education and the sphere of labor in the context of diﬀerent educational models has been conducted. Thus, for example, within the framework of the professional model of the educational process organization, the possibilities of building individual educational programs are limited by the amount of labor intensity of the variable part of the educational program according to the ﬁeld of study or subject specialism. At the same time, we are talking about professional individual educational programs, which are based on the processes of the formation of professional subjectivity of the student and the formation of his/her professional image. Such individual educational programs not only orient students on a certain type of work activity already at university, but also guarantee a well-grounded choice of the future profession. The paper focuses on the signiﬁcant impact of the individualization of professional and professionalization of individual educational programs, as well as the multilevel structure of higher education on the nature of the integration of educational programs of higher education and the trajectories of professional development of young professionals. It is emphasized that the adaptation of students to the educational process, built on the principles of individualization of educational programs, is a key point of interdisciplinary psychological and pedagogical problems of the development of creative abilities of students and is accompanied by the mastery of new skills.
Transformation of the information sphere of civil society
Authors: Levashov V K
Published: November 2019

The author considers new phenomena in the information sphere of civil society, their influence on the nature and forms of its development, emphasizing that the development of the Russian civil society follows the general formation of the global civil society. Humankind has come to the objectively inevitable and qualitatively new stage in the co-evolution of biosphere, society and technosphere - the emergence of noosphere. The social-political essence of the new stage of social evolution is the search for a sustainable life regime based on the principles of civil justice in the interests of everyone on the planet. Social statistics and sociology highlight the peculiarity in the development of digital technologies - the growth of material and informational dysfunctions of the global and regional scale. The information sphere that has developed in the neoliberal paradigm of economic, political, and social practices does not meet the new global challenges and the needs of civil society and social state for it continues to function in the interests of small elite groups. Misinformation becomes widespread, which leads to the loss by information of its key function of the reliable reflection of reality and to the partial transformation of the media into institutions of social and political manipulation. Based on the data of sociological studies, the author proves that the structure and forms of the Russian media dysfunctions reflect global trends, and concludes that the need for publicity is a result of the “truth crisis”; thus, the media’s task - to reliably reflect social reality - becomes an imperative and a pass to the future. The sustainable development of the global and Russian civil society depends on the successful social-political reconstruction of the information sphere based on the principles of co-evolution of man, society and nature.
PENDEKATAN ARSITEKTUR PERILAKU DALAM PENGEMBANGAN KONSEP MODEL SEKOLAH RAMAH ANAK
Authors: Fakriah Nurul
Published: November 2019

Salah satu komponen penting dalam rangka mewujudkan Kota Layak Anak adalah persentase jumlah Sekolah Ramah Anak. Beberapa indikator telah dikembangkan dalam mengembangkan Sekolah Ramah Anak. Sekurang-kurangnya terdapat dua faktor yang berpengaruh dalam mengindikasikan sebuah sekolah ramah anak. Yaitu faktor proses pembelajaran dan infrastruktur yang tersedia. Kajian ini mencoba menemukan sebuah konsep model Sekolah Ramah Anak melalui pendekatan arsitektur perilaku di dalam perancangan infrastrukturnya. Dengan menggunakan pendekatan arsitektur perilaku, maka sekolah ramah anak yang diharapkan pemerintah dapat terwjud sesuai dengan namanya yaitu ramah terhadap anak.
DIAGNOSIS KESULITAN BELAJAR SISWA DALAM PEMBELAJARAN AKTIF DI SEKOLAH
Authors: Darimi Ismail
Published: November 2019

Lazy and helpless, indifferent and standing against teachers is part of the learning problems of students. The problem tendency not all students can complete in itself. Teachers contribute to help solve the problems faced by students, the teacher's role is needed by learners, the diagnosis aims to determine where lies the learning difficulties faced by the students as well as to find solutions. If the students' learning difficulties is allowed, then the learning objectives will not be achieved well. To overcome these difficulties, the students need help, both in digesting the teaching materials as well as in overcoming other barriers. Students' learning difficulties should be identified and can be addressed as early as possible, so that the instructional goals can be achieved with good. It is necessary to diagnosis of the implementation of this diagnosis helps students to acquire maximum learning results. To conduct the diagnosis of learning difficulties must be taken several phases of activities such as 1) Identify students who are expected to have learning difficulties; 2) localizes learning difficulties; 3) Determine the factors that cause learning difficulties; 4) Estimate of alternative aid; 5) Establish the possibility of how to overcome them; and 6) Follow-up. The diagnosis of learning difficulties do with the testing techniques and nontes. The technique can be used by teachers to diagnose learning difficulties, among others: the test requirements (prerequisite knowledge, skill prerequisites), diagnostic tests, interviews and observations.
The correlation of plasma protein binding and molecular properties of selected antifungal drugs
Authors: Odovic Jadranka , Crevar-Sakac Milkica , Vujic Zorica
Published: November 2019

Antifungal agents are the group of drugs commonly prescribed in the treatment of fungal infections, which are widely spread among the global population. Their properties, such as absorption, distribution, metabolism, route of elimination or plasma protein binding (PPB), considerably influence their therapeutic success, while a number of the molecular physicochemical properties of the drug notably influence all these processes. Lipophilicity (log P), molecular weight (Mw), volume (Vol), polar surface area (PSA) and solubility (log S) play important roles in drug absorption, penetration into tissues, distribution and route of elimination or the degree of plasma protein binding. In this study, the relationships between these five molecular properties of eight antifungal drugs and their plasma protein binding data obtained from relevant literature were investigated. The Selected physicochemical molecular descriptors of the drug were calculated using software packages. The established relationships between PPB and PSA; Mw; Vol and log S were showed relatively poor correlation (r < 0.35). The best correlation was obtained for the relationship between PPB data and the lipophilicity descriptor X log P3 (correlation coefficient r = 0.55). In further investigation, multiple linear regression analysis was applied. The best correlation was obtained with application of lipophilicity with polar surface area (r = 0.918) and volume (r = 0.916) or molecular weight (r = 0.896) as independent variables.
ANALISIS KEBUTUHAN UNTUK PENGEMBANGAN MEDIA PEMBELAJARAN IPA BERBASIS MIND MAPPING
Authors: Dadi I Ketut , Redhana I Wayan , Juniartina Putu Prima
Published: November 2019

Tujuan penelitian ini adalah melakukan analisis kebutuhan untuk merancang media pembelajaran IPA berbasis mind mapping. Analisis kebutuhan dilakukan melalui studi literatur dan studi lapangan. Studi literatur dilakukan untuk mengumpulkan informasi mengenai konsep materi IPA di kelas VIII semester 2. Hasil analisis konsep pada materi cahaya dan alat optik menunjukan bahwa 44% konsep abstrak, 52% konsep konkret, dan 4% konsep berdasarkan prinsip. Studi lapangan dilakukan untuk mengumpulkan informasi mengenai proses pembelajaran di kelas dan media yang digunakan. Hasil analisis kebutuhan dari 19 orang guru IPA dan 190 orang siswa di Kabupaten Buleleng khususnya di Kecamatan Buleleng dan Kecamatan Sawan menunjukan bahwa 100% guru menyatakan media pembelajaran IPA berbasis mind mapping itu menarik, 100% guru menginginkan perlunya dikembangkan media pembelajaran IPA berbasis mind mapping dan 100% guru menyatakan setuju menggunakan media pembelajaran IPA berbasis mind mapping dalam menjelaskan konsep IPA. Hasil analisis kebutuhan siswa juga mendapatkan hasil yang tidak jauh berbeda dengan hasil analisis kebutuhan guru, 95,3% siswa menyatakan media pembelajaran IPA berbasis mind mapping itu menarik dan 97,4% siswa menyatakan setuju menggunakan media pembelajaran IPA berbasis mind mapping pada kegiatan belajar di kelas. Hasil studi literatur dan studi lapangan menunjukkan bahwa perlu dikembangkan media pembelajaran IPA berbasis mind mapping.
Chronic Plaque Psoriasis Exacerbated by Telmisartan Therapy: A Case Report
Authors: . Amisha , Malik Paras , Pathania Monika , Rathaur Vyas Kumar
Published: November 2019

Background: Psoriasis is an immune-mediated chronic inflammatory dermatosis with a complex interplay of environmental and genetic factors. Among the various documented triggers, drug-related psoriasis constitutes a distinct entity with exposure resulting in either induction or exacerbation of psoriasis. Here we describe the case of a 45-year-old female with telmisartan aggravated chronic plaque psoriasis previously well controlled on oral methotrexate.
Service Quality and Consumer Choice of Their Preferred Telecommunications Service Provider in Ghana
Authors: Jephthah Kwame Afako , Jeremiah Kwaku Afako , Hongyun Tian
Published: November 2019

This study examines the effect of service quality on customer choice. Specifically, it investigated the relationship between service quality dimensions and customer choice, examining the effect of service quality dimensions on customer choice and the service quality dimension most preferred by customers. The quantitative research approach was used with a sample of 250 respondents using purposive and convenient sampling technique. Questionnaires were used to collect the data and analyzed using SPSS version 21. With regards to the correlation variables, it showed a strong positive relationship between service quality dimensions and customer choice of a mobile network service provider and the regression variables showed a significant effect between service quality and customer choice indicating that service quality is very important and influence customers’ choice in choosing a mobile network service provider. It was recommended that Mobile network service providers should continue to improve on the service quality dimensions (empathy, responsiveness, reliability assurance, and tangibility). Since customers look out for these dimensions when choosing a mobile network service provider.
The Role Of Organizational Citizenship Behavior In Work Performance: An Investigation Based On Hotel Employee Survey
Authors: Reynaldi Reynaldi , Ridjal Syamsul , Sjahruddin Herman
Published: November 2019

This study aims to analyze the role of organizational citizenship behavior in explaining the influence of organizational support and work environment on employee work performance at the Grand Asia Hotel Makassar. The sampling method used is non-probability sampling that is 77 respondents. The analysis used in hypothesis testing is Structural Equation Modeling (SEM) with the help of WarpPLS Software version, 6.0. The results of this study indicate that organizational support has a positive and significant effect on organizational citizenship behavior, work environment has a positive and significant effect on organizational citizenship behavior, organizational citizenship behavior, organizational support has a positive and significant effect on employee work performance, the work environment has a positive and not significant effect on employee work performance, organizational support has a positive and significant effect on employee work performance mediated by organizational citizenship behavior, work environment has a positive and significant effect on employee work performance mediated by organizational citizenship behavior. In this study organizational citizenship behavior is proven to be a mediating variable.
Comparison of intramuscular administration of alfaxalone-ketamine-dexmedetomidine and alfaxalone-butorphanol-midazolam in naked mole-rats (Heterocephalus glaber)
Authors: Eshar David , Huckins Gail L. , Shrader Trenton C. , Beaufrère Hugues
Published: November 2019

OBJECTIVE

To compare anesthetic effects of alfaxalone-ketamine-dexmedetomidine (AKD) and alfaxalone-butorphanol-midazolam (ABM) in naked mole-rats (Heterocephalus glaber).

ANIMALS

20 naked mole-rats.

PROCEDURES

Naked mole-rats received AKD (alfaxalone, 2 mg/kg; ketamine, 20 mg/kg; and dexmedetomidine, 0.02 mg/kg; n = 10) or ABM (alfaxalone, 2 mg/kg; butorphanol, 2 mg/kg; and midazolam, 1 mg/kg; 9) IM; 1 animal was removed from the study. Atipamezole (I mg/kg) and flumazenil (0.1 mg/kg) were administered 40 minutes after anesthetic induction (defined as loss of the righting reflex) with AKD and ABM, respectively. Heart rate, respiratory rate, oxygen saturation, and reflexes were recorded every 5 minutes.

RESULTS

The ABM group had significantly longer median times for induction and recovery than the AKD group. Administration of ABM resulted in significantly lower respiratory rates than administration of AKD from time of anesthetic induction to 10 minutes after induction. Respiratory rate significantly decreased in the AKD group from I0 minutes after induction through the end of the anesthetic period but did not change over time in the ABM group. Males had higher respiratory rates in both groups. Loss of the righting reflex was still evident 40 minutes after induction in both groups. In the AKD group, all tested reflexes were absent from I0 to 40 minutes after induction; the ABM group had variable reflexes that recovered within individual animals over time.

CONCLUSIONS AND CLINICAL RELEVANCE

Both AKD and ABM provided effective immobilization in naked mole-rats, but AKD appeared to provide more consistent and deeper anesthesia, compared with administration of ABM.
Tarsocrural joint polymyxin B concentrations achieved following intravenous regional limb perfusion of the drug via a saphenous vein to healthy standing horses
Authors: Snowden Robert T. , Schumacher James , Blackford James T. , Cypher Ellie E. , Cox Sherry K. , Sun Xiaocun , Whitlock Brian K.
Published: November 2019

OBJECTIVE

To determine whether therapeutic concentrations (> 0.5 to 1.0 μg/mL) of polymyxin B (PB) were achieved in the tarsocrural joint of horses when the drug was administered by IV regional limb perfusion (IV-RLP) via a saphenous vein at doses of 25, 50, and 300 mg and to describe any adverse systemic or local effects associated with such administration.

ANIMALS

9 healthy adult horses.

PROCEDURES

In the first of 2 experiments, 6 horses each received 25 and 50 mg of PB by IV-RLP via a saphenous vein with at least 2 weeks between treatments. For each treatment, a tourniquet was placed at the midmetatarsus and another was placed midway between the stifle joint and tarsus. Both tourniquets were removed 30 minutes after the assigned dose was administered. Blood and tarsocrural joint fluid samples were collected for determination of PB concentration before and at predetermined times after drug administration. In experiment 2, 4 horses were administered 300 mg of PB by IV-RLP in 1 randomly selected pelvic limb in a manner identical to that used in experiment 1.

RESULTS

For all 3 doses, the mean synovial fluid PB concentration was > 10 times the therapeutic concentration and below the level of quantification at 30 and 1,440 minutes after drug administration, respectively. No adverse systemic or local effects were observed following PB administration.

CONCLUSIONS AND CLINICAL RELEVANCE

Results suggested that IV-RLP of PB might be a viable alternative for treatment of horses with synovial infections caused by gram-negative bacteria.
Comparison of the effects of a dexmedetomidine-ketamine-midazolam anesthetic protocol versus isoflurane inhalation anesthesia on echocardiography variables and plasma cardiac troponin I concentration in black-tailed prairie dogs (Cynomys ludovicianus)
Authors: Ross Evan , Thomason Justin D. , Browning Geoffrey R. , Beaufrère Hugues , Eshar David
Published: November 2019

OBJECTIVE

To compare the effects of a dexmedetomidine-ketamine-midazolam (DKM) anesthetic protocol versus isoflurane inhalation anesthesia on echocardiographic variables and plasma cardiac troponin 1 (cTnI) concentration in black-tailed prairie dogs (BTPDs; Cynomys ludovicianus).

ANIMALS

Nine 6-month-old sexually intact male captive BTPDs.

PROCEDURES

Each BTPD was randomly assigned to be anesthetized by IM administration of dexmedetomidine (0.25 mg/kg), ketamine (40 mg/kg), and midazolam (1.5 mg/kg) or via inhalation of isoflurane and oxygen. Three days later, each BTPD underwent the alternative anesthetic protocol. Echocardiographic data and a blood sample were collected within 5 minutes after initiation and just prior to cessation of each 45-minute-long anesthetic episode.

RESULTS

Time or anesthetic protocol had no significant effect on echocardiographic variables. For either protocol, plasma cTnI concentration did not differ with time. When administered as the first treatment, neither anesthetic protocol significantly affected plasma cTnI concentration. However, with regard to findings for the second treatments, plasma cTnI concentrations in isoflurane-treated BTPDs (n = 4; data for 1 animal were not analyzed because of procedural problems) were higher than values in DKM-treated BTPDs (4), which was suspected to be a carryover effect from prior DKM treatment.

CONCLUSIONS AND CLINICAL RELEVANCE

The DKM and isoflurane anesthetic protocols did not have any significant effect on echocardiographic measurements in the BTPDs. Increases in plasma cTnI concentration during the second anesthetic episode were evident when BTPDs underwent the DKM anesthetic protocol as the first of the 2 treatments, suggestive of potential myocardial injury associated with that anesthetic protocol. Clinicians should consider these findings, especially when evaluating BTPDs with known or suspected cardiac disease.
Analysis of External Root Resorption of the Second Molar Associated with an Impaction of the Third Molar by the Application of CBCT
Authors: Velickovic Stefan , Zivic Milos , Rajkovic Zlata , Stanisic Dragana , Misic Aleksandra , Vasovic Miroslav
Published: November 2019

External root resorption (ERR) of a tooth represents a process in which irreversible damage occurs to solid dental tissues, more precisely of the cement and dentin. External resorption occurs on the root surface or periodontal ligament, and it is manifested by the loss of cement and/or dentine. The prevalence of ERR of the second molar associated with an impacted third molar, based on retro-alveolar radiography and orthopantomography, ranges from 0.3% to 24.2%. The aim of this research was to analyze ERR of the upper and lower jaw associated with the impacted third molar by the application of the Come Beam Computed Tomography. This study included 96 third molars in the upper and lower jaw of a total of 46 analyzed patients’ images. Total prevalence of the second molar ERR associated with the impacted third molar was 8.82%. The second molar ERR was observed in 8 patients (7.84%). Frequency of the second molar ERR in the lower jaw is higher, and it is 8.2%, while in the upper jaw it is only 1% (r = 0.032). Impacted third molars associated with the second molar ERR were most frequently in horizontal (5.1%) and mesioangular (4.1%) position (p = 0.000). The second molar ERR could be avoided by the preventive extraction of mesioangular or horizontal third molars. An adequate decision on the extraction of impacted third molars must be made by the careful assessment of risks and benefits of this surgical intervention. Before the surgical intervention, an adequate care of the second molar, adequate restoration, endodontic treatment or root resection should be done if necessary.
CULTURES AND PROFESSIONAL COMMUNICATION IN STANDARD SITUATIONS: DIFFERENCES IN COMMUNICATIVE BEHAVIOUR
Authors: Samokhina T. S.
Published: November 2019

Successful interaction across cultures requires cultural awareness and cultural intelligence which help the participants of communication select effective verbal and nonverbal means to realize their communicative intention. The paper addresses communicative strategies of representatives of different cultures in similar communicative situations. The author shows conclusively that though the Americans and the British share the same language their communicative behavior differs in typical situations of business interaction, which makes them use different verbal and nonverbal means to achieve their communicative goals. Due to the cultural differences, Russian speaking students need to be taught these differences to achieve cultural intelligence.
Audit Keamanan TI Menggunakan Standar ISO/IEC 27002 dengan COBIT 5
Authors: David Purba Altry , Adi Purnawan I Ketut , Agus Eka Pratama I Putu
Published: November 2019

Keamanan teknologi informasi merupakan kebutuhan vital bagi organisasi untuk menjamin kerahasiaan, integritas dan ketersediaan informasi. Salah satu organisasi yang membutuhkan keamanan TI adalah Lembaga X. Lembaga X yang memiliki tugas dan fungsi sebagai penyelenggara sistem informasi, pusat data dan informasi kebencanaan harus mampu menjamin keamanan, kerahasiaan, dan integritas data, juga kinerja sistem harus dikendalikan sehingga dapat berjalan dengan optimal. Audit keamaman TI dilakukan untuk memastikan bahwa keamanan informasi dan pengelolaan data yang diterapkan di Lembaga X sesuai dengan prosedur serta mengetahui tingkat kematangan teknologi informasi yang diterapkan. Standar yang digunakan dalam proses audit adalah ISO/IEC 27002 sebagai kontrol keamanan dan COBIT 5 untuk mengidentifikasi proses bisnis serta tingkat kematangan. Hasil tingkat kematangan TI di lembaga X adalah 2.48 yang masuk ke dalam kategori level 2: Managed Process. Level 2: Managed Process menunjukkan bahwa proses penerapan teknologi informasi telah dijalankan dan diimplementasikan dengan cara yang lebih teratur dan sudah mulai dikendalikan.Kata Kunci: Audit Keamanan, ISO 27002, COBIT 5, Tingkat Kematangan
Penerapan Augmented Reality Video Dinamis dalam Pembelajaran Peredaran Darah Berbasis Android
Authors: Wipra Astiti Ida Ayu Putu , Arya Sasmita Gusti Made , Sukarsa Made
Published: November 2019

Peredaran darah merupakan suatu pelajaran penting yang harus diketahui oleh siswa siswi dalam pelajaran biologi. Banyak siswa yang kurang dalam pemahaman saat dijelaskan dengan buku atau alat peraga. Terbatasnya alat peraga dan ketertarikan para siswa untuk belajar mendominasi pemanfaatan alat elektronik sebagai bahan ajar. Teknologi yang semakin canggih dapat dimanfaatkan sebagai sarana belajar mengajar yang menarik. Penerapan teknologi augmented reality dalam pembelajaran peredaran darah menjadi salah satu solusi. Augmented reality video dinamis berbasis android dimanfaatkan untuk membantu minta siswa belajar lebih efektif. Video yang digunakan dapat diambil dari video yang sudah ada ataupun rancangan video animasi sendiri. Aplikasi dikembangkan dengan marker. Fitur yang ditampilkan pada aplikasi memiliki 4 scene, yaitu 3D Statis, Video Dinamis, About dan Exit. Fitur utama aplikasi adalah 3D Statis yang berisi informasi mengenai bentuk jantung dan Fitur Video Dinamis, dimana jika marker di scan akan memunculkan video penjelasan mengenai peredaran darah pada jantung. Hasil dari aplikasi ini yaitu berupa aplikasi yang dijalankan dalam perangkat mobile Android dan dapat memberikan informasi mengenai peredaran darah pada jantung. Kualitas aplikasi menurut penilaian dari responden adalah baik, dengan persentase grafis sebesar 64%, presentase rekayasa perangkat lunak 71% dan presentase entertainment application yaitu 81%.

Kata kunci: peredaran darah, augmented reality, video dinamis, marker, Android
Peran Kader Dalam Penerapan Sistem Rujukan dan Pencegahan Komplikasi Pada Ibu Dan Bayi Terhadap Kematian Neonatal
Authors: Widayati Agustina , Rohmatin Homsiatur , Narsih Umi
Published: November 2019

Kematian neonatal menjadi perhatian penting karena memberikan kontribusi terhadap 59% kematian bayi. Program Perencanaan Persalinan dan Pencegahan Komplikasi (P4K) masih belum berjalan secara optimal karena diperlukan sinergisitas antara bidan, ibu, suami, keluarga, masyarakat dan kader posyandu. Tujuan penelitian ini adalah menganalisisperan kader posyandu dalam penerapan sistem rujukan dan pencegahan komplikasi pada ibu dan bayi sehingga dapat mencegah kematian neonatal.Rancang bangun yang digunakan adalahrestrospective study dengan populasi seluruh kader posyandu di Kabupaten Probolinggo.Teknik sampling menggunakan purposive sampling dan diperoleh sampel 66 kader posyandu yang memenuhi kriteria inklusi. Pengumpulan data menggunakan kuesioner dan wawancara. Analisis data menggunakan chi square test.Hasil penelitian menginformasikan bahwa sebagian besarkader posyandukurang berperan aktif dalam penerapan sistem rujukan dan pencegahan komplikasi pada ibu dan bayi, serta sebagian terjadi kematian neonatal. Sehingga ada hubungan yang signifikan antara peran kader posyandu dalam penerapan sistem rujukan dan pencegahan komplikasi pada ibu dan bayiterhadap kematian neonatal.
Implementasi Web Scraping untuk Pengambilan Data pada Situs Marketplace
Authors: A. Yani Dhita Deviacita , Pratiwi Helen Sasty , Muhardi Hafiz
Published: November 2019

Perdagangan elektronik atau e-commerce merupakan proses penyebaran, pembelian, penjualan, pemasaran barang dan jasa melalui sistem elektronik seperti internet. E-commerce dapat melibatkan transfer dana elektronik, pertukaran data elektronik, sistem manajemen inventori otomatis, dan sistem pengumpulan data otomatis. Di Indonesia, terdapat beberapa perusahaan yang bergerak dalam bidang e-commerce, yang beberapa diantaranya adalah Bukalapak, Elevenia, dan JD.id. Setiap perusahaan tersebut memiliki situs web dimana calon pembeli dapat mencari, memilih, dan membeli produk yang diinginkan. Agar dapat mengambil keputusan yang terbaik ketika melakukan proses perbelanjaan, selain seorang calon pembeli yang harus melakukan pencarian di beberapa situs marketplace mengenai produk yang hendak dibeli secara manual juga mereka ingin mencari produk yang terbaik berdasarkan jumlah produk dengan penjualan terbanyak atau terlaris. Dengan bantuan aplikasi web pencarian terbaik dan teknik web scraping ini akan mampu melakukan pencarian di beberapa situs marketplace dan menampilkan hasil pencarian secara bersamaan. Menurut hasil pengujian dengan menggunakan white box testing dan black box testing, sistem telah mampu memberikan hasil terbaik produk dari gabungan hasil pencarian di tiga situs web marketplace sesuai kata kunci yang dimasukkan oleh pengguna.
DNP-enhanced NMR of Lithium Dendrites: Selective Observation of the Solid–Electrolyte Interphase
Authors: Hope Michael , Rinkel Bernadine L. D. , Gunnarsdottir Anna B. , Marker Katharina , Menkin Svetlana , Paul Subhradip , Grey Clare P.
Published: November 2019

Li metal anodes represent the ultimate energy density, but to address safety issues caused by dendrite formation, it is critical to understand the solid–electrolyte interphase (SEI) layer which forms on the metal surface. Dynamic nuclear polarisation (DNP) boosts sensitivity in NMR by harnessing the greater polarisation of unpaired electrons, however typical exogenous organic radicals are non-selective, could react with the SEI, and require cooling the sample to cryogenic temperatures. We instead exploit the inherent conduction electrons to hyperpolarise lithium metal at room temperature, utilising the Overhauser mechanism by which DNP was first discovered. This permits selective enhancement of the organic and inorganic SEI components, revealing their chemical nature and spatial distribution, via the 7Li, 1H and 19F NMR spectra.