bluuebunny/crossref_metadata_2025 huggingface dataset:
LES LIGNES ANGLAISES D’EMMANUEL CARRÈRE : LA GREFFE DE "BRAVOURE"
Authors: TERMITE Marinella
Published: November 2018

Emmanuel Carrere’s English lines: the case of grafting in the novel Bravoure. The kind of sharing that supports the testamentary type of tools is based as much on the transmission of programmatic filiation as on creative networks capable of bypassing any lineage. The written page is thus submitted to the test of time and space by questioning its genesis, its transformations but especially the scriptural means to explore the limits and advantages of sharing. How does one read by writing ? How does heritage act upon the rewriting of any texts ? What remains of M. Shelley’s Frankenstein in E. Carrère’s Bravoure?
Rezumat. Rândurile englezești ale lui Emmanuel Carrère: grefa din romanul Bravoure. Genul de intertextualitate pe care se sprijină instrumentarul de tip testamentar se bazează, în egală masură, pe transmiterea unei filiații programatice, ca și pe acele rețele creative apte să opereze în afara oricărei descendențe. Pagina scrisă este astfel supusă testului timpului și spațiului prin investigarea genezei, a transformărilor sale, dar mai cu seamă a mijloacelor scripturale de explorare a limitărilor și avantajelor intertextualității. Cum se citește scriind? Cum acționează moștenirea textuală asupra procesului de rescriere a oricărui text? Ce rămâne din Frankenstein-ul lui Mary Shelley în romanul Bravoure al lui Emmanuel Carrère?
Cuvinte-cheie: Emmanuel Carrère, Mary Shelley, Moștenire, Dezmoștenire
A minimally invasive surgical technique for ureteral ostioplasty in two fillies with ureteral ectopia
Authors: Jones Andrew R. E. , Ragle Claude A.
Published: November 2018

CASE DESCRIPTION 2 fillies, aged 3 months and 1 month, were examined because of urinary incontinence and urine scalding.

CLINICAL FINDINGS In horse 1, ultrasonography did not reveal any structural abnormalities of the kidneys; however, unilateral ureteral ectopia was diagnosed cystoscopically. In horse 2, CT revealed bilateral nephropathy, bilateral distended ureters (up to 3.6 cm in diameter), and bilateral ureteral ectopia. Cystoscopy revealed intramural ureteral ectopia with abnormally caudally positioned ureteral ostia in both horses.

TREATMENT AND OUTCOME Ureteral ostioplasty was performed under cystoscopic guidance. Laparoscopic scissors (horse 1) or a vessel-sealing device (horse 2) was introduced, and the tissue separating the intramural portion of the ureter from the urethra and bladder was cut longitudinally in a cranial direction toward the trigone. After surgery, both horses were continent and voided normal streams of urine for the duration of the follow-up periods of 20 and 9 months for horse 1 and horse 2, respectively.

CLINICAL RELEVANCE Cystoscopically guided ureteral ostioplasty provided an effective and minimally invasive surgical treatment option for correction of ureteral ectopia in 2 fillies.
Art as the Manifestation of Embodiment in the Age of Modern technology
Authors: Indrajaya Ferdinand
Published: November 2018

It is undeniable that modern technology has been penetrating our contemporary life in myriad aspects. From the water we drink, foods we eat, to the installed applications inour phone. Hence modern technology has become one dominating worldview on itsown which skips our reflection upon it. Its rapid growth stems from the dismissal oftradition and simultaneously with the tremendous scientific discoveries with its inherentinstrumental rationality. It actively participates in serving the irrational dimension ofour cybernetics-contemporary life. Thus it is not a neutral ensemble of devices, butnormatively-prescriptive directs our being in achieving our goals mechanically. AsHeidegger said, it enframes our being in the world in a disembodied fashion. Enframing,is the quintessence of modern technology. Merleau-Ponty, as another ardent critic, alsostated that modern technology is essentially manipulative. Under the heading of scientism(and or cybernetics), it anesthetizes humanity as its own manipulandum. Contrastingwith such view, art potentially re-attunes our relation with things. From Merleau-Ponty’sphenomenological perspective, art (especially painting) powerfully shows the prereflectiveand embodied contact with the world. This paper is an attempt to show the roleofart in a life that has been eclipsed by the modern technological worldview.
drawing perform’s: An Artistic research
Authors: Mustaqim Karna
Published: November 2018

The determination of academic research on the field of the arts education troubling its own artistic practices. It was assumed by clarifying the objective and method of doing the research, art was believed would be contributing to a greater intellectualisation, otherwise it is just an art practice without justification from science, and therefore no contribution worth to human knowledge. Since it contrastive to the nature of artistic practice embodied in the arts itself, which unfortunately not even realize by the artist his/herself. Whilst it is well said by Joseph Kosuth (1971) that: “the artist, not unlike a scientist for whom there is no distinction between working in the laboratory and writing a thesis, has now “to cultivate the conceptual implications of his art propositions, and argue their explication.” This paper is about explicating the writer as the artist himself who done the livedexperience of drawing performs as the research processed. Artists use drawings an activity or a way of understanding the meaning of who we are and how we lived in the world. However, the objective of this research is an exceptional one, it searches for the dual experiences of the researcher as the artist as the instrument who producing the drawing and as the spectators himself welcoming and appreciating as he/she reveals him/ herself capable of wondering. In a particular way, this research is to show that through the making of drawings, the drawing performs lived-experience, that it can be another paradigm so called art-based or artistic research.
DEKONSTRUKSI BENDA SEHARIHARI DALAM KARYA SENI LUKIS
Authors: Setyawan Anton Budi
Published: November 2018

Kebudayaan selain sebagai sebuah tatanan nilai, bahasa, ilmu pengetahuan, religi dan sistem mata pencaharian juga merangkum persoalan mekanisme penggunaan peralatan hidup berupa benda-benda yang dipergunakan dalam keseharian sekelompok masyarakat. Kebudayaan juga bicara soal benda/objek/artefak. Setiap kelompok dan lapisan masyarakat telah memahami bagaimana benda-benda tersebut bergerak pada wilayah fungsi dan simbol. Persoalan narasi dalam benda-benda keseharian akan menjadi menarik bila dijadikan sebagai subject matter penciptaan karya seni rupa. Sebagai sebuah upaya untuk melepaskan diri dari genre seni lukis still life yang melukis objek benda sehari-hari dengan pendekatan estetika formalistik, penulis kemudian memilih mendekonstruksi benda-benda keseharian tersebut dengan tujuan untuk memaknai ulang narasi kebendaan agar kontekstual dengansituasisosialdankulturalsaatini. Culture than as a value system, language, science, religion and livelihood systems also summarizes the problems of life equipment usage mechanism in the form of objects used in everyday life of a people. Culture is also about things/objects/artifacts. Each groups and walks of life have to understand how these objects moving in the area of the function and symbol. The issue of narration in everyday objects will become attractive when used as the subject matter of the creation of works of art. As an effort to break away from the genre of still life paintings, which is painted everyday objects with formalistic aesthetic approach, the authors then chose to deconstruct objects daily with the aim to redefine the narrative material to be contextual with the social and cultural situation today.
Perancangan Komunikasi Visual Kampanye Pengurangan Konsumtivisme
Authors: Swaratama Elfa
Published: November 2018

erilaku konsumtif dapat mengakibatkan dampak-dampak negatif seperti membuat

seseorang untuk memiliki pola hidup boros dan dapat membuat orang menjadi tidak

lagi membedakan antara kebutuhan akan tetapi mengutamakan keinginan.

Perancangan komunikasi visual, kampanye pengurangan konsumtivisme ini bertujuan

untuk mengurangi sifat konsumtif khususnya generasi muda. Metode pengumpulan

data yang digunakan dalam perancangan ini adalah kualitatif deskriptif, serta

perancangan ini melalui tiga tahap, yaitu pembuatan konsep kampanye, konsep media,

dan pembuatan konsep kreatif berdasarkan studi literatur, observasi, dan wawancara

terhadap target audiensi. Berdasarkan penelitian berupa observasi dan wawancara

terhadap target audiensi didapati bahwa media-media yang akan digunakan sebagai

media kampanye berdasarkan intensitas pemakaiannya adalah sosial media Facebook

dan Instagram. Sedangkan isi pesan yang akan disampaikan adalah "Belilah Barang

sesuai dengan Fungsinya", dengan cara penyajian pesan yaitu dengan menggunakan

humor satir. Kampanye ini dirancang dalam bentuk lima buah poster yang akan

disebarkan di media sosial seperti yang telah disebutkan di atas, dengan karakter

visual dan verbal yang kontroversial. Penggunaan karakter tersebut diharapkan dapat

membantu target audiensi untuk turut menyebarkan pesan tersebut sehingga

kampanye ini akan menjadi viral.

Consumer behavior can lead to negative effects such as making a person to have an

extravagant lifestyle and can make people no longer distinguish between needs and

desire. Visual communication design consumerism reduction campaign aims to

reduce the consumptive nature of the young generation. Data collection methods used

in this design is qualitative descriptive, and this design through three stages, namely

the concept of the campaign, the concept of media, and the making of creative

concepts based on the study of literature, observation, and interviews with the target

audience. Based on research in the form of observations and interviews with the target

audience, found that the media will be used as a media campaign based on the

intensity of their use of social media is Facebook and Instagram. While the contents

of the message to be conveyed is "buy goods in accordance with its function", by way

of presenting a message that is using satirical humor. The campaign is designed in

the form of five posters that will be distributed in social media such as those mentioned

above, with the controversial visual and verbal content that is expected to help the

target audience to also spread the message so that this campaign will become viral.
PENINGKATAN POTENSI DAN PENGEMBANGAN ATRAKSI WISATA BUDAYA BATIK DI DESA JARUM
Authors: Aji Ganes Satya
Published: November 2018

Kajian Wisata Seni Budaya Batik Berwawasan Lingkungan di Desa Jarum merupakan kajian yang dibahas dalam penelitian ini. Maksud dan tujuan penelitian ini adalah untuk menjawab permasalahan: pertama, potensi apa saja yang bisa dikembangkan untuk meningkatkan kualitas atraksi wisata budaya batik Desa Jarum; kedua, bagaimana rancangan pengembangan atraksi wisata budaya batik Desa Jarum. Penelitian ini bersifat pengamatan dengan pendekatan kuantitatif terhadap kawasan yang akan dikembangkan menjadi desa wisata budaya batik, dengan menggunakan alat pengumpulan data berupa studi pustaka, pengamatan lapangan dan wawancara. Adapun sumber data yang diperoleh di lokasi penelitian dengan mencari narasumber yang kompeten, sumber data dari instansi pemerintah juga swasta yang mendukung dan relevan. Analisis data dilakukan dengan metode SWOT yang digunakan untuk mengkaji semua aspek yang memengaruhi berupa potensi dan permasalahan baik di lingkup internal maupun eksternal, sehingga akan teridentifikasi hubungan sumber daya industri kreatif dengan sumber daya lainnya. Fungsi dari analisis SWOT adalah dapat mengetahui apa saja potensi atau kekuatan yang mendukung dalam pengembangan wisata budaya batik di Desa Jarum. Hasil penelitian menunjukkan bahwa desa wisata Jarum secara organisasi dalam kondisi prima sehingga sangat dimungkinkan untuk terus melakukan ekspansi, memperbesar pertumbuhan, dan meraih kemajuan maksimal, memiliki keunggulan potensi seni budaya, seperti budaya batik yang selama ini telah menghidupi banyak pengrajin. Atraksi belajar batik sebagai atraksi utama tidak dapat membuat wisatawan lebih lama tinggal di Desa Jarum, sehingga perlu dilakukan pengembangan atraksi lainnya. Dengan kondisi minimnya potensi sumber daya alam, maka direkomendasikan untuk melakukan pengembangan atraksi buatan yang berwawasan lingkungan, memperluas pasar dengan memaksimalkan strategi promosi, dan bekerjasama dengan stakeholder untuk mewujudkan kebutuhan sarana dan prasarana yang dibutuhkan. Usaha kepariwisataan di Desa Jarum akan terus meningkat dengan adanya dukungan dari seluruh masyarakat, sehingga organisasi harus mampu merangkul seluruh elemen masyarakat, melakukan inovasi, dan menjaga kualitas layanan serta pengelolaan.   Kata kunci: atraksi wisata, seni budaya batik, lingkungan
Pengaruh Nilai Iklan yang Dipersepsikan dan Getok Tular terhadap Minat Wisata Kota Yogyakarta Dimediasi oleh Citra Destinasi
Authors: Syarifuddin Mustika
Published: November 2018

Penelitian ini bertujuan untuk menguji pengaruh nilai iklan yang dipersepsikan dan getok tular (wom) terhadap minat wisata kota di Kota Yogyakarta dengan dimediasi oleh citra destinasi. Penelitian ini dilakukan di Kota Yogyakarta dengan mensurvei 386 responden wisatawan domestik. Teknik pengambilan sampelnya dengan sistem acak menggunakan sampling daerah (cluster). Metode analisis datanya menggunak an analisis regresi sederhana bertahap dan analisis mediasi. Hasil penelitian ini menemukan adanya pengaruh signifikan dan positif antara nilai iklan yang dipersepsikan dan getok tular terhadap citra destinasi. Penelitian ini menunjukkan pula bahwa adanya pengaruh signifikan secara langsung maupun tidak langsung antara nilai iklan yang dipersepsikan dan getok tular terhadap minat wisata Kota Yogyakarta melalui citra destinasi sebagai variabel pemediasi komplementer. Abstract The purpose of this study was to examine the influences of perceived advertising value and word of mouth on intentions of city visit Yogyakarta is mediating by destination image. This research was conducted in the city of Yogyakarta with 386 respondents by surveying domestic tourists. Sample collection techniques with a system using a random sampling area (cluster). Methods of data analysis using stages of simple regression and mediation analysis. The results of this study found a significant and positive influ ence between perceived advertising value and word of mouth on the destination image. This study also shows that significant influence, directly or indirectly between it perceived value advertising and word of mouth to the intentions of city visit Yogyakarta through the destination image as a variable complementary mediator.
Hubungan Motivasi dan Kepuasan Relawan pada Organisasi Seni
Authors: Pangestu Jangkung Putra
Published: November 2018

Relawan merupakan asset penting pada organisasi seni. Memahami motivasi dan kepuasan sangat diperlukan dalam merekrut maupun mengelola relawan. Tujuan utama penelitian ini adalah untuk mengetahui hubungan motivasi dan kepuasan relawan selama mengikuti kegiatan sukarela di tiga organisasi seni yaitu Komunitas Gayam 16, Jogja-NETPAC Asian Film Festival (JAFF) dan Yayasan Biennale Yogyakarta. Metode yang digunakan adalah metode survey dengan kuesioner Volunteer Functions Inventory (VFI) yang disusun oleh Clary, dkk (1998). Data diperoleh dari 179 responden dengan cara menyebarkan kuesioner cetak dan kuesioner elektronik (GoogleForm). Data yang terkumpul, dianalisis menggunakan metode analisis deskriptif, korelasi product moment Kruskall-Wallis dan Mann-Whitney. Hasil penelitian menunjukkan bahwa dari enam dimensi motivasi yang diajukan, fungsi pemahaman, fungsi karir dan fungsi peningkatan, mempunyai peran penting dalam memotivasi seseorang menjadi relawan, serta mempunyai hubungan yang kuat dan signifikan dengan kepuasan. Motivasi relawan juga dapat dipengaruhi oleh jenis organisasi dan faktor demografi. Temuan ini dapat menjadi bahan pertimbangan bagi para pengelola untuk mendapatkan relawan yang sesuai dengan organisasi. Pengelola dapat menyusun sistem pengelolaan relawan yang efektif meskipun hasil dari penelitian ini tidak bisa digeneralisir. Penelitian ini diharapkan menjadi titik awal bagi penelitian berikutnya mengenai kesukarelawanan pada organisasi seni. Volunteers are the most important assets of an arts organization. Understanding motivation and satisfaction is needed in recruiting and managing the volunteer. The m ain purpose of this research is to find out the correlation between volunteer motivation and satisfaction in three arts organizations, Komunitas Gayam 16, Jogja-NETPAC Asian Film Festival and Yayasan Biennale Jogja. The method used is survey method using Vo lunteer Function Inventory (VFI) developed by Clary et al. (1998). Data from 179 respond ents were collected through an hard copy and online questionnaires managed through GoogleForm. The collected data were analyzed using discriptive statistics, produc t moment correlation, Kruskall-Wallis dan Mann-Whitney. The result indicated that among six motivation functions, the understanding, career and enhancement are the most popu lar reasons for volunteering and significanly related to volunteer satisfaction level. Vo lunteer motivation can also be influenced by organization type and demographic factors. Th is findings have implication for arts manager to get the type of volunteer for their p articular type of organization. The arts manager can develop effectively volunteer m anagement system. This study serves as a starting point for more research on volunteerism in ar ts organizations.
Efecto de la Temperatura sobre el Crecimiento de Tilapia (Oreochromis sp) en Mamá Lombriz, Vereda Rio Blanco, Popayán, Colombia.
Authors: Bonilla Paz Blanca Lilia , Montoya Bonilla Bibiana , Gómez Jorge , Caja Álvaro
Published: November 2018

El objetivo del trabajo fue evaluar el efecto que tiene el incremento de temperatura en el agua sobre el crecimiento de la Tilapia (Oreochromis sp), a partir del uso de mantas térmicas que permitan reducir el tiempo de producción en Popayán, donde las limitaciones agroclimáticas afectan los requerimientos comerciales, y la alta demanda gastronómica. El experimento evaluó durante 6 meses el crecimiento en peso y talla de 20.000 alevines, divididos en 2 tratamientos y un control, cada uno con tres repeticiones, los alevines se recibieron de 2 cm con 2,5 gr en promedio y se entregaron en promedio con 18 cm con 58 gr en promedio, lo que evidencio un incremento del 45% en el desarrollo de los individuos, comparados con el estanque de control (T1 18ºC), los tratamientos consistían en establecer estanques con invernadero (T2 22ºC) y estanques con invernadero y manta térmica (T3 26,5ºC). Los mejores resultados en cuanto a crecimiento fueron obtenidos con el T3. El estanque de control presento los resultados más bajos en índices de talla y peso con respecto a la bibliografía y comparado con los otros tratamientos; en cada tratamiento se evaluó la incidencia del incremento de temperatura sobre el oxígeno disuelto y el pH, evidenciando que ello no afecta los rangos propios de tolerancia en el cultivo.
Simulador empresarial y contable: Estrategia pedagógica para aprender en ambientes reales de información
Authors: Carmona Movilla Luis Alberto , Utria Payares Laura
Published: November 2018

En el presente documento, se muestra el diseño de un simulador empresarial y contable como estrategia pedagógica para la enseñanza de la Contaduría Pública en el marco de las tecnologías de la información y la comunicación (TIC), con el fin de que los estudiantes de esta profesión aprendan a desarrollar en ambientes reales de información, el proceso contable que conlleva a la elaboración y análisis de los estados financieros, así como también, a la preparación y presentación de las declaraciones tributarias en Colombia. El simulador es producto de un diagnóstico realizado a una población de 74 estudiantes de último semestre del programa de Contaduría Pública de la Fundación Universitaria Tecnológico Comfenalco durante el segundo periodo académico del año 2012. Se encontró que los estudiantes presentan problemas para desarrollar el proceso contable y tributario en ambientes reales de información.
Syntheses of Colloidal F:In2O3 Cubes: Fluorine-Induced Faceting and Infrared Plasmonic Response
Authors: Cho Shin Hum , Ghosh Sandeep , Berkson Zachariah J. , Hachtel Jordan A. , Shi Jianjian , Zhao Xunhua , Reimnitz Lauren C. , Dahlman Clayton J. , Ho Yujing , Yang Anni , Liu Yuanyue , Idrobo Juan-Carlos , Chmelka Bradley F. , Milliron Delia
Published: November 2018

Cube-shaped nanocrystals (NCs) of conventional metals like gold and silver generally exhibit localized surface plasmon resonance (LSPR) in the visible region with spectral modes determined by their faceted shapes. However, faceted NCs exhibiting LSPR response in the infrared (IR) region are relatively rare. Here, we describe the colloidal synthesis of nanoscale fluorine-doped indium oxide (F:In2O3) cubes with LSPR response in the IR region, wherein fluorine was found to both direct the cubic morphology and act as an aliovalent dopant. Single crystalline 160 nm F:In2O3 cubes terminated by (100) facets and concave cubes were synthesized using a colloidal heat-up method. The presence of fluorine was found to impart higher stabilization to the (100) facets through density functional theory (DFT) calculations that evaluated the energetics of F-substitution at surface oxygen sites. These calculations suggest that the cubic morphology results from surface binding of F-atoms. In addition, fluorine acts as an anionic aliovalent dopant in the cubic bixbyite lattice of In2O3, introducing a high concentration of free electrons leading to LSPR. We confirmed the presence of lattice fluorine dopants in these cubes using solid-state 19F and 115In nuclear magnetic resonance (NMR) spectroscopy. The cubes exhibit narrow, shape-dependent multimodal LSPR extinction peaks due to corner- and edge-centered modes. The spatial origin of these different contributions to the spectral response are directly visualized by electron energy loss spectroscopy (EELS) in a scanning transmission electron microscope (STEM).
Study of the Similarity Between Molecules Through the Comparison of Thermo-chemical Properties
Authors: De Angeli Tetsafe
Published: November 2018

Chemical similarity between molecules, is a key concept in drug design and drug discovery. The advance in computational science, had given rise to many new possibilities for understand difference and similarity between molecules. In particular, is very important the QSAR (quantitative structure–activity relationship ) paradigm (1). Typical approaches to calculate chemical similarities use chemical fingerprints or QSAR, but this doesn´t consider the thermochemical properties of the molecules. In others words chemical similarity is described as an inverse of a measure of distance in descriptor space. In this work is presented a new method, for calculate chemical similarities
El universo simbólico entorno de la sociedad de la beneficencia en la política social argentina
Authors: Moniec Susana
Published: November 2018

En base a la historia de la Sociedad de la Beneficencia Argentina y a partir de la perspectiva teórica que brindan Alfred Schutz (1995), Peter Berger y Tomas Luckman (2005), en éste artículo se describe y analiza la forma en que funcionan algunos símbolos, que ésta institución instaló, en la construcción de un campo de significado para la intervención social.
La tierra para el que la trabaja: política y género en la reforma agraria chilena
Authors: Tinsman Heidi
Published: November 2018

La reforma agraria chilena, un proyecto de modernización y transformación social radical, incluía tanto las mujeres como a hombres campesinos a través de un modelo de “familia moderna” en cual el hombre se transformaría en buen proveedor para la familia y productor para la nación, mientras la mujer se transformaría en una dueña de casa moderna. Este proyecto beneficiaba a las mujeres casadas pero las hizo económicamente más dependientes de los hombres, lo que generó agudos conflictos conyugales. Para las mujeres solteras y jóvenes, la reforma agraria fue distinta, les ofrecía más oportunidades sociales y de trabajo. Esto creó una nueva cultura juvenil rural que produjo nuevos conflictos entre madres e hijas.
Цитотоксическое действие конструкций на основе дендримеров с 188Re с моноклональными антителами анти-ICO-25 (MUC1) и анти-ICO-80 (CD5) На моделях клеточных линий SKOV-3 (рак яичника) и Jurkat (Т-лимфобластная лимфома)
Authors: Григорьева Елена Юрьевна , Стукалов Юрий Викторович , Смирнова Анна Вячеславна , Колдаева Елена Юрьевна , Калыгина Нина Сергеевна , Кулаков Виктор Николаевич , Барышников Анатолий Юрьевич
Published: November 2018

Перспективным направлением лучевой терапии является адресная (таргетная) радиоиммунотерапия. В разработанной конструкции опухолеспецифичностью обладали моноклональные антитела анти-ICO-25 (MUC1) и анти-ICO-80 (CD5), а терапевтическим радионуклидом является 188Re. Адресность (таргетность) созданных конструкций была показана in vitro на моделях клеточных линий SKOV-3 (рак яичника) и Jurkat (Т-лимфобластная лимфома), которые характеризуются наличием на мембране специфических рецепторов к соответствующим антителам. Результаты оценки кратковременной цитотоксичности показали 90 – 93 % гибель клеточных популяций, что свидетельствует о перспективности изучаемых конструкций с направленной доставкой в создании диагностических и терапевтических препаратов онкологического назначения.
Оптимизация первой стадии синтеза эноксапарина методом гидролитической деполимеризации нефракционированного гепарина
Authors: Фрумин Леонид Ерухимович , Юрьева Кристина Павловна , Аскретков Александр Дмитриевич , Прохоров Денис Игоревич , Матвеев Андрей Валерьевич , Жаворонок Елена Сергеевна , Панов Алексей Валерьевич , Шаталов Денис Олегович , Шняк Елизавета Александровна , Кедик Станислав Анатольевич
Published: November 2018

Исследована первая стадия получения низкомолекулярного гепарина (эноксапарина) методом гидролитической деполимеризации нефракционированного гепарина, которая заключается в химическом взаимодействии исходного гепарина с хлоридом бензетония в водно-солевых (NaCl) растворах. Показано, что с повышением концентрации хлорида натрия у нефракционированного гепарина определяется большее количество кислотных эквивалентов. Вероятно, это связано с влиянием ионной силы раствора на конформацию макромолекулы гепарина, что подтверждается данными метода динамического рассеяния света. Средний размер наблюдаемых центров светорассеяния в водных растворах гепарина падает с увеличением концентрации хлорида натрия. Показано, что для ускорения очистки гепарината бензетония от исходных реагентов, а также для снижения количества промывных вод целесообразно применять промывание водой, а не растворами хлорида натрия, а также использовать ультразвуковую обработку. Состав полученных и очищенных образцов гепарината бензетония подтвержден методом 1H ЯМР.
Разработка и валидация методики количественного определения фенибута в микрокапсулах
Authors: Полковникова Юлия Александровна , Корянова К. Н. , Сливкин А. И. , Тульская У. А. , Сенченко С. П.
Published: November 2018

Методом капиллярного электрофореза проведена разработка и валидация методики количественного определения фенибута в микрокапсулах. Показано, что при использовании в качестве ведущего электролита 10 мМ раствора натрия тетраборнокислого 10-водного с рН 9,2 достигаются достаточно высокие параметры эффективности (около 200 000 т.т.) и необходимое разрешение (Rs ≥ 1,5). Проведенная валидационная оценка разработанной методики показала, что методика является специфичной, а по показателям аналитическая область и линейность соответствует требованиям ГФ XIII изд.
Модуляторы глутаматных NMDA-рецепторов — перспективная группа антидепрессантов
Authors: Кудряшов Никита Викторович , Устинова Мария Викторовна , Калинина Татьяна Сергеевна
Published: November 2018

Модуляторы NMDA-рецепторов — новая группа антидепрессантов, отличительной особенностью которой является быстрый антидепрессивный эффект, сохраняющийся в течение длительного времени. Подобно классическим антидепрессантам, модуляторы NMDA-рецепторов повышают уровень мозгового нейротрофического фактора (BDNF) в различных структурах ЦНС, ассоциированных с депрессией, и стимулируют поздний постнатальный гиппокампальный нейрогенез. Однако, в отличие от классических антидепрессантов, препараты данной группы не воздействуют напрямую на моноаминергическую систему, а регулируют процессы нейропластичности в префронтальной коре и гиппокампе посредствам модуляции глутаматергической синаптической передачи. Основными достоинствами кетамина и рапастинеля, продемонстрированными в ряде клинических исследований, является быстрый и стойкий антидепрессивный эффект (1 введение в 7 дней), который наблюдается при обычных и резистентных формах депрессии.
Новые антибактериальные средства в эпоху глобальной резистентности
Authors: Карева Елена Николаевна , Сереброва Светлана Юрьевна , Лазарева Наталья Борисовна , Шипилова Светлана Юрьевна , Булгакова Виля Ахтямовна , Козаева Лариса Петровна , Кононова Ирина Николаевна , Яровой Сергей Константинович , Дроздов Владимир Николлаевич , Стародубцев Алексей Константинович
Published: November 2018

Частота формирования резистентности патогенных мироорганизмов к противомикробным препаратам продолжает расти. Это ведет к появлению таких бактериальных инфекций, которые, по существу, не поддаются лечению современным арсеналом доступных лекарственных средств. Были предприняты различные усилия для разработки новых противомикробных препаратов, которые могут действовать на штаммы патогенов с лекарственной устойчивостью. Приведены сведения о некоторых новых молекулах, одобренных после 2000 г., механизмах их действия, спектрах антибактериальной активности, показаниях к применению и релевантных терапевтических схемах.
Psychodynamic Theory and Therapy of Male Pedophilia: The Role of Object Relations, Structural Conflicts, and Narcissism
Authors: Phelan James
Published: November 2018

This paper is about theory and therapy of pedophilia and provides a case illustration.
An Association Rule General Analytic System (ARGAS) for hypothesis testing and data mining applications
Authors: Parente Rick
Published: November 2018

The primary purpose of this study was to evaluate the use of an Association Rule General Analytic System (ARGAS) versus the General Linear Model (GLM) for hypothesis testing. Results indicate that the ARGAS provides an better alternative method for testing hypotheses when the assumptions of the GLM are violated. The ARGAS approach can be used with any experimental design to which the GLM can be applied. ARGAS is free of the usual assumptions of the GLM. A second purpose of the study was to illustrate how the ARGAS can be used for hypothesis testing with commonly used experimental designs.
Open Video Repositories for College Instruction
Authors: Miller Michael , CohenMiller Anna
Published: November 2018

Key features of open video repositories are
outlined, followed by brief description of specific sites relevant to the
social sciences. Although most were created by instructors over the past 10
years to facilitate teaching and learning, significant variation in kind,
quality, and number per discipline were discovered. Economics and Psychology
have the most extensive sets of repositories, while Political Science has the
least development. Among original-content websites, Economics has the strongest
collection in terms of production values, given substantial support from
wealthy donors to advance political and economic agendas. Sociology stands out
in having the most developed website in which found-video is applied to
teaching and learning. Numerous multidisciplinary sites of quality have also
emerged in recent years.
Kontrolni mehanizmi djelovanja upravnih sudova u Republici Hrvatskoj
Authors: Galić Ante
Published: November 2018

U ovom radu autor analizira kontrolne mehanizme djelovanja upravnih sudova sagledavajući ih u njihovoj slojevitosti i sveobuhvatnosti, kroz kontrolne mehanizme koji omogućuju kontrolu ustavnosti i zakonitosti odluka sudova te kontrolne mehanizme propisane organizacijskim propisima, čija je svrha kontrola zakonitosti rada sudaca i predsjednika sudova. Prvi spektar kontrolnih mehanizama uglavnom derivira iz temeljnog zakona kojim je reguliran upravni spor (Zakon o upravnim sporovima), a djelomice i iz odredaba Ustava i Ustavnog zakona o Ustavnom sudu Republike Hrvatske, dok je drugi spektar kontrolnih mehanizama arhetipski vezan za organizacijske propise. Iako ova dva spektra kontrolnih mehanizama generiraju iz različite vrste propisa, nedvojbeno je kako oni zajedno čine jednu komplementarnu cjelinu kontrolnih mehanizama.
Izmjena odredaba ugovora o iskorištavanju ugljikovodika
Authors: Brnabić Ratko
Published: November 2018

Seizmografska istraživanja čiji je naručitelj Vlada Republike Hrvatske ukazuju na to da jadransko podmorje sadrži zalihe ugljikovodika. Iako tu nije riječ o posebice bogatim zalihama, rezultati tih početnih istraživanja pobuđuju interes multinacionalnih trgovačkih društava koja se bave preradom ugljikovodika. Pravna sigurnost gospodarskog pothvata tim društvima jedna je od najvažnijih pretpostavki za ulaganje. Taj zahtjev će se ispuniti s(p)retnom i umješnom kombinacijom zakonodavnog uređenja tog gospodarskog područja države domaćina s jedne strane te sklapanjem posebnih „tailor made“ ugovora s druge, što predstavlja veliki izazov za ugovorne strane. Naime, ugovori o iskorištavanju ugljikovodika moraju kao i svaki drugi ugovor biti odraz svih načela obveznog prava pa je u tom smislu potrebno pronaći pravu ravnotežu između načela ravnopravnosti ugovornih strana i načela pacta sunt servanda, ali i zahtjeva inozemnog trgovačkog društva koje ulaže znatna sredstva u pothvat i očekuje određene povlastice koje će omogućiti razmjerno brz povrat barem početno uloženih sredstava. Ne smije se zaboraviti da je tu riječ o višegodišnjim ugovorima koji trebaju izdržati test ponekad burnih gospodarskih ali i društveno-političkih promjena te treba utvrditi jesu li se okolnosti toliko promijenile da je za jednu od ugovornih strana ispunjenje ugovornih obveza otežano ili se više ne može ostvariti niti svrha ugovora. Kod spomenutih ugovora, raskid ugovora najčešće nije u interesu ugovornih strana. U radu se provodi raščlamba najvažnijih odredaba tih ugovora te se predlažu rješenja koja bi tim pravnim poslovima dala potrebnu razinu prilagodljivosti svim gospodarsko-političkim promjenama koje će sigurno nastati.
Iznimno zakonsko propisivanje kažnjivosti pokušaja
Authors: Moslavac Bruno
Published: November 2018

Opće pravilo o kažnjavanju i kažnjivosti pokušaja kaznenog djela zasebno je normirano u okviru materijalnog kaznenog zakonika, koji istovremeno propisuje i brojne slučajeve posebnog kažnjavanja pokušaja, onda kada nije moguće primijeniti osnovno pravilo koje se oslanja na zapriječenu kaznu za pojedino kazneno djelo.
Posebno pravno pravilo o kažnjivosti pokušaja normirano je kroz odrednicu „ako zakon izričito propisuje kažnjavanje i za pokušaj“.
U ovome radu autor detaljno prikazuje i raščlanjuje sve posebne pojavne oblike kažnjivosti pokušaja, utvrđujući njihovu zastupljenost, katalog u hrvatskom kaznenom zakonodavstvu, uspoređujući težine izvorno zapriječenih kazni za pojedino kazneno djelo za koje je iznimno kažnjiv pokušaj i analizirajući njihovu zastupljenost po svakom pojedinom dijelu kaznenog zakonika.
Zaključno se ističe kako se zakonodavac odlučio posebno kažnjavati pokušaj i kod kaznenih djela iz domene tzv. bagatelnog kriminaliteta, sa zapriječenom kaznom zatvora do jedne godine, uz brojna kaznena djela sa zapriječenom kaznom zatvora do tri godine, što ukazuje na opravdanost zakonodavnog rješenja da je neophodno inkriminirati posebne slučajeve kada pokušaj kaznenog djela mora biti kažnjen, iako se nalaze izvan domašaja općeg pravila o kažnjivosti pokušaja.
Generiranje suvremenog terorizma kroz prizmu negativnih konotacija globalizacije – primjer BiH
Authors: Pustahija Almir
Published: November 2018

Autor u radu analizira suvremeni terorizam, posebno naglašavajući dubinske dimenzije uzrokovanja, rađanja, proizvodnje suvremenog terorizma, istovremeno se osvrćući kritički na negativne konotacije globalizacije, odnosno na globalne procese u svijetu i ključne faktore koji uveliko doprinose stvaranju nesigurnosti s pratećim posljedicama. Pristup koji je u radu primijenjen može objasniti rađajuću suštinu suvremenog terorizma, da bi se društvo kao takvo oslobodilo okova uvriježenosti u vidu apsorpcije dolazećih necjelovitih i spinovanih informacija, proizvodeći strah od terorističkih aktivnosti. Također, u radu su sa kazneno-procesnog i sigurnosnog aspekta analizirani teroristički akti koji su se desili u Bosni i Hercegovini od njezine samostalnosti do danas, ukazujući istovremeno na mogućnost produbljivanja te vrste nesigurnosti, odnosno fenomena suvremenog terorizma koji se reflektira na posebne načine u društvu, ali i na specifičnosti ukupnog sektora sigurnosti Bosne i Hercegovine i njegove borbe u prevenciji i suzbijanju unutarnjeg, međudržavnog, kao i transnacionalnog terorizma. Zaključak u radu referira na činjenicu da pored državnih institucija koje su involvirane u aktivnostima suzbijanja i borbe protiv terorizma, postoje i druge instance koje su se aktivnije uključile u spomenutom djelovanju, kao što su vjerske institucije/zajednice u Bosni i Hercegovini.
Zaštita osobnih podataka i Europska konvencija za zaštitu ljudskih prava i temeljnih sloboda
Authors: Klarić Mirko
Published: November 2018

Predmet ovoga rada jest zaštita osobnih podataka kao temeljnog ljudskog prava u svjetlu Europske konvencije za zaštitu ljudskih prava i temeljnih sloboda. Daju se prikaz i analiza odredbi Konvencije za zaštitu pojedinaca pri automatskoj obradi osobnih podataka Vijeća Europe, kao temeljnog pravnog akta koji uređuje zaštitu osobnih podataka i pravo na privatnost pojedinca, a koji u odnosu na Europsku konvenciju za zaštitu ljudskih prava i temeljnih sloboda predstavlja lex specialis, koji se posebno bavi jednom kategorijom ljudskih prava, koja, zbog ubrzanog tehnološkog razvoja, postaje sve značajnija i važnija. Nakon analize načela koje sadrži Konvencija za zaštitu pojedinaca pri automatskoj obradi osobnih podataka, i koja kao takva predstavljaju osnovu za uspostavu pravnog okvira Europske unije za zaštitu osobnih podataka, analizira se Direktiva Europskog parlamenta i Europskog vijeća o zaštiti pojedinaca u vezi s obradom osobnih podataka i slobodnom protoku takvih podataka, kao i odgovarajući propisi u državama članicama: Hrvatskoj, Velikoj Britaniji, Francuskoj, Njemačkoj i Nizozemskoj. Na kraju se iznose empirijski pokazatelji vezani uz korištenje osobnih podataka, te se u zaključku interpretiraju rezultati istraživanja kroz analizu važnosti koju ima zaštita osobnih podataka kao poseban oblik zaštite ljudskih prava u svjetlu Europske konvencije za zaštitu ljudskih prava i temeljnih sloboda.
The wealth -> life history -> innovation account of the industrial revolution is largely inconsistent with empirical time series data.
Authors: Varnum Michael E. W. , Grossmann Igor
Published: November 2018

Baumard proposes a model to explain the dramatic rise in innovation that occurred during the Industrial Revolution, whereby rising living standards led to slower life history strategies, which in turn fostered innovation. We test his model explicitly using time series data, finding limited support for these proposed linkages. Instead, we find evidence that rising living standards appear to have a bidirectional relationship with increasing innovation.
Hidden invalidity among fifteen commonly used measures in social and personality psychology
Authors: Hussey Ian , Hughes Sean
Published: November 2018

Flake, Pek, and Hehman (2017) recently demonstrated that metrics of structural validity are severely underreported in social and personality psychology. We apply their recommendations for the comprehensive assessment of structural validity to a uniquely large and varied dataset (N = 144496 experimental sessions) to investigate the psychometric properties of some of the most widely used self-report measures (k = 15 questionnaires, 26 subscales) in social and personality psychology. When assessed using the modal practice of considering only their internal consistency, 89% of scales appeared to possess good validity. Yet, when validity was assessed comprehensively (via internal consistency, immediate and delayed test-retest reliability, factor structure, and measurement invariance for median age and gender) only 4% demonstrated good validity. Furthermore, the less commonly a test is reported in the literature, the more likely it was to be failed (e.g., measurement invariance). This suggests that the pattern of under- reporting in the field may represent widespread hidden invalidity of the measures we use, and therefore pose a threat to many research findings. We highlight the degrees of freedom afforded to researchers in the assessment and reporting of structural validity. Similar to the better-known concept of p-hacking, we introduce the concept of validity hacking (v-hacking) and argue that it should be acknowledged and addressed.
The science behind Bayley v the Queen (2016)
Authors: Skalon Alena , Beaudry Jennifer L
Published: November 2018

Eyewitness identification was the principal evidence in DPP v Bayley (2015), in which Adrian Bayley received a jail sentence for the rape and assault of a woman that took place in 2000. Twelve years after the attack, the victim identified Bayley from a photograph seen on Facebook and later in a formal police identification procedure. At the time of the initial Facebook identification the victim knew about Bayley’s involvement in Gillian Meagher’s case. Bayley successfully appealed this conviction in 2016. The Court of Appeal held that the identification evidence in this case had multiple weaknesses and should not have been permitted at the initial trial. In the decision, the Court relied on legal precedents to support their judgement. In this article we review the empirical evidence regarding each of the issues raised by the Court. In addition, we review how the stressfulness of an event can influence the reliability of an identification, and explore why the jury may have rendered a guilty verdict based on the weak identification evidence.
Neural Substrates of Early Executive Function Development
Authors: Fiske Abigail , Holmboe Karla
Published: November 2018

In the last decade, advances in neuroimaging technologies have given rise to a large number of research studies that investigate the neural underpinnings of executive function (EF). EF has long been associated with the prefrontal cortex (PFC) and involves both a unified, general element, as well as the distinct, separable elements of working memory, inhibitory control and set shifting. We will highlight the value of utilising advances in neuroimaging techniques to uncover answers to some of the most pressing questions in the field of early EF development. First, this review will explore the development and neural substrates of each element of EF. Second, the structural, anatomical and biochemical changes that occur in the PFC during infancy and throughout childhood will be examined, in order to address the importance of these changes for the development of EF. Third, the importance of connectivity between regions of the PFC and other brain areas in EF development is reviewed. Finally, throughout this review more recent developments in neuroimaging techniques will be addressed alongside the implications for further elucidating the neural substrates of early EF development in the future.
Preprint: Empirically-based comparisons of the reliability and validity of common quantification approaches for eyeblink startle potentiation in humans
Authors: Bradford Daniel E. , Starr Mark J. , Shackman Alexander J. , Curtin John Joseph
Published: November 2018

Startle potentiation is a well validated translational measure of negative affect. Startle potentiation is widely used in clinical and affective science and there are multiple approaches for its quantification. The three most commonly used approaches quantify startle potentiation as the increase in startle response from a neutral to threat condition based on 1) raw potentiation, 2) standardized potentiation or 3) percent-change potentiation. These three quantification approaches may yield qualitatively different conclusions about effects of independent variables on affect when within or between group differences exist for startle response in the neutralcondition. Accordingly, we directly compared these quantification approaches in a shock-threat task using four independent variables known to influence startle response in the no-threat condition: probe intensity, time (i.e., habituation), alcohol administration, and individual differences in general startle reactivity measured at baseline. We confirmed the expected effects of time, alcohol, and general startle reactivity on affect using self-reported fear/anxiety as a criterion. The percent-change approach displayed apparent artifact across all four independent variables, which raises substantial concerns about its validity. Both raw and standardized potentiation approaches were stable across probe intensity and time, which supports their validity. However, only raw potentiation displayed effects that were consistentwith a priori specifications and/or the self-report criterion for the effects of alcohol and general startle reactivity. Supplemental analyses of reliability and validity for each approach provided additional evidence in support of raw potentiation.
Demographic Profile and Outcome of Mechanically Ventilated Children in a Tertiary Care Hospital of a Developing Country
Authors: Sahoo Bandya , Jain Mukesh Kumar , Thakur Bhaskar , Mishra Reshmi , Patnaik Sibabratta
Published: November 2018

Introduction: The need for mechanical ventilation (MV) is an absolute indication for admission to Paediatric intensive care unit (PICU). Management of children requiring invasive ventilation in resource limited developing countries is challenging. Scare data is available from Asian countries regarding use of MV in PICUs. The objectives of this study were to determine the clinical profile, characteristics, common causes for ventilation, ventilation related complications and final outcome of these patients.Material and Methods: A retrospective study of children requiring ventilator support in PICU of Kalinga Institute of Medical Sciences from January 2014 to December 2016 was done. Data collected included epidemiological trends, indications for ventilation, complications, length of stay on ventilator and outcome.Results: A total of 1172 patients were admitted to PICU, 101 (8.6%) patients required MV. 42% of the mechanically ventilated patients were infants and 75% were males. Impending respiratory failure (34.6%) and low Glasgow coma scale (17.8%) were the commonest indication for ventilation in this study. The median length of MV was 2.1 days. The mortality rate of these children was 38.6%. We report the epidemiological trends, frequency, indications and outcomes of children requiring ventilator support in PICU. Analysis of this data can be helpful in improving outcome in future by planning better treatment strategies.Conclusion: The frequency of MV in our PICU is low. Respiratory failure was the most common reason for mechanical ventilation.