bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk Management and Agency Theory: Role of the Put Option in Corporate Bonds
Authors: Tewari Manish , Ramanlal Pradipkumar
Published: January 2022

This study sets out a new methodology to exemplify, through a set of risk metrics called the Greeks, impact of a bond’s structured provisions (e.g., call, put, and conversion options) on its risk characteristics and its propensity for agency conflicts. The methodology is assessed by applying it to a sample of 159 non-convertible bonds, with time-scheduled call and put provisions issued between 1977 and 2005. A structural contingent-claims valuation model is used to value the bonds and estimate the Greeks. The methodology is used to assess the impact of the call and put provisions on the bond’s credit risk and interest-rate risk, as well as the provisions’ ability to mitigate the agency conflict associated with over-investment, under-investment, asset-substitution, and information asymmetry about the firm’s true risk among stakeholders. The main findings of this study are that the put option plays a key role in reducing credit risk, mitigating agency conflict, and protecting against volatility shocks; conversely, the call option plays a key role in reducing interest-rate risk. The methodology is sufficiently general to apply to bonds and preferred stock with any set of structured provisions.
Immune Disregulation in Cutaneous Squamous Cell Carcinoma of Patients with Recessive Dystrophic Epidermolysis Bullosa: A Single Pilot Study
Authors: Filoni Angela , Cicco Gerolamo , Cazzato Gerardo , Bosco Anna , Lospalluti Lucia , Tucci Marco , Cimmino Antonietta , Foti Caterina , Marzullo Andrea , Bonamonte Domenico
Published: January 2022

Background: Cutaneous squamous cell carcinoma (cSCC) is one of the most devastating complications of recessive dystrophic epidermolysis bullosa (RDEB). We recently demonstrated a reduction in immune cell peritumoral infiltration in RDEB patients with cSCC, together with a reduction in CD3+, CD4+, CD68+ and CD20 lymphocytes as compared to primary and secondary cSCC in patients without RDEB. Recently, new molecules, such as high mobility group box 1 (HMGB1), T cell immunoglobulin, mucin domain 3 (TIM-3) and Heme oxygenase-1 (HO-1), have been shown to play a role in antitumoral immunity. Objective: Patients with RDEB are known to be at increased risk of developing skin cancers, including the dreaded squamous cell carcinoma of the. Tendentially, cSCCs that arise in the context of EBDR are more aggressive and lead to statistically significant bad outcomes compared to cSCCs developed on the skin of patients without EBDR. In an attempt to study the microenvironment of these lesions, we conducted an immunohistochemical analysis study of proteins that could be actively involved in the genesis of this type of malignant neoplasms. Methods: In this retrospective study, the OH1-HMGB1-TIM3 activation axis, as correlated to the T lymphocytes cell count, was assessed in biopsy samples from 31 consecutive cases consisting of 12 RDEB patients with cSCC, 12 patients with primary cSCC and 7 RDEB patients with pseudoepitheliomatous cutaneous hyperplasia. Parametric Student’s t-test was applied for normally distributed values, such as CD4+ and CD8+, and non-parametric Mann–Whitney test for non-normally distributed values, such as HMGB-1, TIM-3 and HO-1. Results: In RDEB patients with cSCC and with pseudoepitheliomatous hyperplasia, the expression of CD4 T helper lymphocytes was lower than in the peritumoral infiltrate found in primary cSCC. CD8 cytotoxic T lymphocytes were increased in primary cSCC compared to the other two groups. An increased HMGB1 expression was evident in both primary and RDEB cSCC. TIM3 expression was higher in RDEB patients with cSCC compared to the other two groups. A significantly reduced immunohistochemical expression of HO-1 was evident in the tumoral microenvironment of cSCC-RDEB as compared to primary cSCC. Conclusions: These data suggest that a reduced immune cell peritumoral infiltration in RDEB patients could be responsible, in the complexity of the mechanisms of carcinogenesis and host response, of the particular aggressiveness of the cSCC of RDEB patients, creating a substrate for greater local immunosuppression, which, potentially, can “open the doors” to development and eventual metastasis by this malignant neoplasm.
Organ Donation after Damage Control Strategy in Trauma Patients: Experience from First Level Trauma Center in Italy
Authors: Altomare Michele , Bekhor Shir Sara , Cioffi Stefano Piero Bernardo , Sacchi Marco , Renzi Federica , Spota Andrea , Bini Roberto , Ambrogi Federico , Pozzi Federico , Chieregato Arturo , Chiara Osvaldo , Cimbanassi Stefania
Published: January 2022

Background: Organ donation (OD) remains the only therapeutic option for end-stage disease in some cases. Unfortunately, the gap between donors and recipients is still substantial. Trauma patients represent a potential yet underestimated pool of organ donors. In this article, we present our data on OD after damage control strategy (DCS). Materials and Methods: A retrospective, observational cohort study was conducted through a complete revision of data of consecutive adult trauma patients (>18 years old) who underwent OD after DCS between January 2018 and May 2021. Four subgroups were created [Liver (Li), Lungs (Lu), Heart (H), Kidneys (K)] to compare variables between those who donated the organ of interest and those who did not. Results: Thirty-six patients underwent OD after DCS. Six patients (16.7%) were excluded: 2(5.6%) for missing data about admission; 4(11.1%) didn’t receive DCS. Mean ISS was 47.2 (SD ± 17.4). Number of donated organs was 113 with an organs/patient ratio of 3.8. The functional response rate was 91.2%. Ten organs (8.8%) had primary nonfunction after transplantation: 2/15 hearts (13.3%), 1/28 livers (3.6%), 4/53 kidneys (7.5%) and 3/5 pancreases (60%). No lung primary nonfunction were registered. Complete results of subgroup analysis are reported in supplementary materials. Conclusion: Organ donation should be considered a possible outcome in any trauma patient. Aggressive damage control strategy doesn’t affect the functional response rate of transplanted organs.
Inhibition of BRUTUS Enhances Plant Tolerance to Zn Toxicity by Upregulating Pathways Related to Iron Nutrition
Authors: Zhu Yaxin , Dai Yujie , Jing Xiangting , Liu Xingxing , Jin Chongwei
Published: January 2022

The identification of the key genes regulating plant tolerance to Zn stress is important for enhancing the Zn phytoremediation of targeted plants. Here, we showed that the T-DNA insertion-induced inhibition of the BRUTUS (BTS) gene in the bts-1 mutant greatly improved Zn tolerance, as indicated by increased biomass production and reduced leaf chlorosis. The ProBTS::BTS-GFP complementation in the bts-1 mutant abolished the improvement of Zn tolerance. Unexpectedly, the bts-1 mutant had higher and comparable Zn concentrations in the roots and citrate effluxer shoots, respectively, compared to wild-type plants. As a result, the shoots and roots of bts-1 mutants had 53% and 193% more Zn accumulation than the wild-type plants, respectively. RNA-seq analyses revealed that the Fe nutrition-related genes were upregulated in bts-1 mutants, especially under Zn stress conditions. Therefore, the bts-1 mutants had a greater Fe concentration and a higher Fe/Zn ratio than the wild-type plants exposed to Zn toxicity. Further study showed that the differences in Zn tolerance between bts-1 and wild-type plants were minimized by eliminating Fe or supplementing excessive Fe in the growth medium. Taken together, the T-DNA insertion-induced inhibition of BTS improves plant Zn tolerance by optimizing Fe nutrition; thus, the knockdown of BTS may be a promising approach for improving Zn phytoremediation efficiency.
Bacillus mycoides PM35 Reinforces Photosynthetic Efficiency, Antioxidant Defense, Expression of Stress-Responsive Genes, and Ameliorates the Effects of Salinity Stress in Maize
Authors: Ali Baber , Wang Xiukang , Saleem Muhammad Hamzah , Azeem Muhammad Atif , Afridi Muhammad Siddique , Nadeem Mehwish , Ghazal Mehreen , Batool Tayyaba , Qayyum Ayesha , Alatawi Aishah , Ali Shafaqat
Published: January 2022

Soil salinity is one of the abiotic constraints that imbalance nutrient acquisition, hampers plant growth, and leads to potential loss in agricultural productivity. Salt-tolerant plant growth-promoting rhizobacteria (PGPR) can alleviate the adverse impacts of salt stress by mediating molecular, biochemical, and physiological status. In the present study, the bacterium Bacillus mycoides PM35 showed resistance up to 3 M NaCl stress and exhibited plant growth-promoting features. Under salinity stress, the halo-tolerant bacterium B. mycoides PM35 showed significant plant growth-promoting traits, such as the production of indole acetic acid, siderophore, ACC deaminase, and exopolysaccharides. Inoculation of B. mycoides PM35 alleviated salt stress in plants and enhanced shoot and root length under salinity stress (0, 300, 600, and 900 mM). The B. mycoides PM35 alleviated salinity stress by enhancing the photosynthetic pigments, carotenoids, radical scavenging capacity, soluble sugars, and protein content in inoculated maize plants compared to non-inoculated plants. In addition, B. mycoides PM35 significantly boosted antioxidant activities, relative water content, flavonoid, phenolic content, and osmolytes while reducing electrolyte leakage, H2O2, and MDA in maize compared to control plants. Genes conferring abiotic stress tolerance (CzcD, sfp, and srfAA genes) were amplified in B. mycoides PM35. Moreover, all reactions are accompanied by the upregulation of stress-related genes (APX and SOD). Our study reveals that B. mycoides PM35 is capable of promoting plant growth and increasing agricultural productivity.
The Influence of Kerosene on Microbiomes of Diverse Soils
Authors: Shelyakin Pavel V. , Semenkov Ivan N. , Tutukina Maria N. , Nikolaeva Daria D. , Sharapova Anna V. , Sarana Yulia V. , Lednev Sergey A. , Smolenkov Alexander D. , Gelfand Mikhail S. , Krechetov Pavel P. , Koroleva Tatiana V.
Published: January 2022

One of the most important challenges for soil science is to determine the limits for the sustainable functioning of contaminated ecosystems. The response of soil microbiomes to kerosene pollution is still poorly understood. Here, we model the impact of kerosene leakage on the composition of the topsoil microbiome in pot and field experiments with different loads of added kerosene (loads up to 100 g/kg; retention time up to 360 days). At four time points we measured kerosene concentration and sequenced variable regions of 16S ribosomal RNA in the microbial communities. Mainly alkaline Dystric Arenosols with low content of available phosphorus and soil organic matter had an increased fraction of Actinobacteriota, Firmicutes, Nitrospirota, Planctomycetota, and, to a lesser extent, Acidobacteriota and Verrucomicobacteriota. In contrast, in highly acidic Fibric Histosols, rich in soil organic matter and available phosphorus, the fraction of Acidobacteriota was higher, while the fraction of Actinobacteriota was lower. Albic Luvisols occupied an intermediate position in terms of both physicochemical properties and microbiome composition. The microbiomes of different soils show similar response to equal kerosene loads. In highly contaminated soils, the proportion of anaerobic bacteria-metabolizing hydrocarbons increased, whereas the proportion of aerobic bacteria decreased. During the field experiment, the soil microbiome recovered much faster than in the pot experiments, possibly due to migration of microorganisms from the polluted area. The microbial community of Fibric Histosols recovered in 6 months after kerosene had been loaded, while microbiomes of Dystric Arenosols and Albic Luvisols did not restore even after a year.
The Anti-Inflammatory, Anti-Apoptotic, and Antioxidant Effects of a Pomegranate-Peel Extract against Acrylamide-Induced Hepatotoxicity in Rats
Authors: Sayed Samy , Alotaibi Saqer S. , El-Shehawi Ahmed M. , Hassan Mohamed M. , Shukry Mustafa , Alkafafy Mohamed , Soliman Mohamed Mohamed
Published: January 2022

The Acrylamide is a toxic compound generated under oxidative stress arising from intracellular ROS production and induced toxicity. It is frequently used in industry and generated through the heating of tobacco and foods high in carbohydrates. The exact mechanism of its toxicity is still unclear. In this study, an extract of the peels of pomegranate (Punica granatum L.), a nutritious and visually appealing fruit with a diverse bioactive profile, was examined for its potential anti-apoptotic, antioxidant, and anti-inflammatory effects. A total of 40 adult male Wistar rats were allocated into four groups of 10 rats each: Group 1 was a negative-control group (CNT) and received normal saline; Group 2 was a positive-control acrylamide group and received acrylamide orally at a dose of 20 mg/kg/bw; in Group 3, the rats were supplemented with pomegranate-peel extract (P.P; 150 mg/kg/bw) orally on a daily basis for 3 weeks, administered simultaneously with the acrylamide treatment described for Group 2; Group 4 was a protective group, and the animals received the pomegranate-peel extract and acrylamide as stated for Groups 2 and 3, with the pomegranate-peel extract (P.P. extract) administered 1 week earlier than the acrylamide. The results indicate that acrylamide exposure increased the serum levels of AST, ALT, creatinine, interleukin-1 beta, and interleukin-6 in an extraordinary manner. In addition, it increased the lipid peroxidation marker malondialdehyde (MDA) and simultaneously weakened antioxidant biomarker activities (SOD, GSH, and catalase) and reduced the levels of interleukin-10. The pomegranate-peel extract was shown to reduce the inflammatory blood markers of interleukin-1 beta and IL-6. Glutathione peroxidase, superoxide dismutase, catalase, and interleukin-10 were all significantly elevated in comparison to the acrylamide-treatment group as a result of the significant reduction in MDA levels induced by the P.P extract. In addition, the pomegranate-peel extract normalized the cyclooxygenase-2 (COX2), transforming growth factor-beta 1 (TGF-β1), and caspase-3 levels, with a significant upregulation of the mRNA expression of heme oxygenase-1 (HO-1), nuclear factor erythroid 2 (Nrf2), and Bcl-2. Therefore, these data reveal that pomegranate peel has anti-inflammatory, antiapoptotic, free-radical-scavenging, and powerful antioxidant activity that protects against acrylamide toxicity.
Machine Learning Based Restaurant Sales Forecasting
Authors: Schmidt Austin , Kabir Md Wasi Ul , Hoque Md Tamjidul
Published: January 2022

To encourage proper employee scheduling for managing crew load, restaurants need accurate sales forecasting. This paper proposes a case study on many machine learning (ML) models using real-world sales data from a mid-sized restaurant. Trendy recurrent neural network (RNN) models are included for direct comparison to many methods. To test the effects of trend and seasonality, we generate three different datasets to train our models with and to compare our results. To aid in forecasting, we engineer many features and demonstrate good methods to select an optimal sub-set of highly correlated features. We compare the models based on their performance for forecasting time steps of one-day and one-week over a curated test dataset. The best results seen in one-day forecasting come from linear models with a sMAPE of only 19.6%. Two RNN models, LSTM and TFT, and ensemble models also performed well with errors less than 20%. When forecasting one-week, non-RNN models performed poorly, giving results worse than 20% error. RNN models extended better with good sMAPE scores giving 19.5% in the best result. The RNN models performed worse overall on datasets with trend and seasonality removed, however many simpler ML models performed well when linearly separating each training instance.
Acoustic Emission b Value Characteristics of Granite under True Triaxial Stress
Authors: Dong Longjun , Zhang Lingyun , Liu Huini , Du Kun , Liu Xiling
Published: January 2022

The acoustic emission b value is an important and widely used parameter for the early prediction of rock fractures. In this study, five groups of true triaxial compression tests were conducted on granite specimens to analyze changes in b value during the process of rock failure, and to investigate the b value characteristics of acoustic emission events. First, the acoustic emission events that simultaneously triggered at least four sensors were located using P-wave arrivals and sensor coordinates. Then, considering various intervals of acoustic emission event counts, stress magnitude, and stress proportion, b values were calculated using the values of the maximum amplitude, average amplitude, maximum absolute energy, and average absolute energy of the acoustic emission events. In addition, the goodness of the fitting curves was used to evaluate the fitting reliability of the b values. The results indicated higher accuracy of b value when calculated using the average amplitude setting for intervals of acoustic emission event counts of 200 or greater, stress magnitude of 20 MPa or greater, and stress proportion of 10% or greater. Moreover, the interval of event counts of 200 is suggested as a window parameter for b value calculations, and the b values are observed to exhibit a decreasing trend before fracture for more than 80% of the specimens. Furthermore, the b value tends to decrease with an increase in confining pressure. Thus, the b value can be used as an indicator for validating the stress concentration area, including magnitudes and accumulative probability density distribution of events, which is a beneficial complement to clarifying precursor information of rock mass instability.
Comparing Distributions of Sums of Random Variables by Deficiency: Discrete Case
Authors: Bening Vladimir E. , Korolev Victor Y.
Published: January 2022

In the paper, we consider a new approach to the comparison of the distributions of sums of random variables. Unlike preceding works, for this purpose we use the notion of deficiency that is well known in mathematical statistics. This approach is used, first, to determine the distribution of a separate random variable in the sum that provides the least possible number of summands guaranteeing the prescribed value of the (1−α)-quantile of the normalized sum for a given α∈(0,1), and second, to determine the distribution of a separate random variable in the sum that provides the least possible number of summands guaranteeing the prescribed value of the probability for the normalized sum to fall into a given interval. Both problems are solved under the condition that possible distributions of random summands possess coinciding three first moments. In both settings the best distribution delivers the smallest number of summands. Along with distributions of a non-random number of summands, we consider the case of random summation and introduce an analog of deficiency which can be used to compare the distributions of sums with random and non-random number of summands. The main mathematical tools used in the paper are asymptotic expansions for the distributions of R-valued functions of random vectors, in particular, normalized sums of independent identically distributed r.v.s and their quantiles. Along with the general case, main attention is paid to the situation where the summarized random variables are independent and identically distributed. The approach under consideration is applied to determination of the distribution of insurance payments providing the least insurance portfolio size under prescribed Value-at-Risk or non-ruin probability.
The Sehgal’s Fixed Point Result in the Framework of ρ-Space
Authors: Secelean Nicolae Adrian , Wardowski Dariusz , Zhou Mi
Published: January 2022

In this paper, we prove a fixed point theorem of Sehgal type (see Sehgal, V.M., Proc Amer Math Soc 23: 631–634, 1969) in a more general setting of ρ-space (see Secelean, N.A. and Wardowski, D., Results Math, 72: 919–935, 2017). In this way, we can find, as particular cases, some results of Sehgal type in metric, b-metric and rectangular b-metric spaces.
A Review of the Modification Strategies of the Nature Inspired Algorithms for Feature Selection Problem
Authors: Abu Khurma Ruba , Aljarah Ibrahim , Sharieh Ahmad , Abd Elaziz Mohamed , Damaševičius Robertas , Krilavičius Tomas
Published: January 2022

This survey is an effort to provide a research repository and a useful reference for researchers to guide them when planning to develop new Nature-inspired Algorithms tailored to solve Feature Selection problems (NIAs-FS). We identified and performed a thorough literature review in three main streams of research lines: Feature selection problem, optimization algorithms, particularly, meta-heuristic algorithms, and modifications applied to NIAs to tackle the FS problem. We provide a detailed overview of 156 different articles about NIAs modifications for tackling FS. We support our discussions by analytical views, visualized statistics, applied examples, open-source software systems, and discuss open issues related to FS and NIAs. Finally, the survey summarizes the main foundations of NIAs-FS with approximately 34 different operators investigated. The most popular operator is chaotic maps. Hybridization is the most widely used modification technique. There are three types of hybridization: Integrating NIA with another NIA, integrating NIA with a classifier, and integrating NIA with a classifier. The most widely used hybridization is the one that integrates a classifier with the NIA. Microarray and medical applications are the dominated applications where most of the NIA-FS are modified and used. Despite the popularity of the NIAs-FS, there are still many areas that need further investigation.
MF–NF Treatment Train for Pig Manure: Nutrient Recovery and Reuse of Product Water
Authors: Samanta Prantik , Schönettin Hannah Marie , Horn Harald , Saravia Florencia
Published: January 2022

The livestock industry negatively impacts the environment by producing high organic and mineral loaded manure and wastewater. On the contrary, manure is also considered as the major focal point of resource recovery. The microfiltration (MF) process in manure treatment is well known for being the least complex and highly energy efficient. However, the major fraction of the dissolve nutrients easily bypasses the MF membranes. In this research work, we reported the efficiency of using MF–nanofiltration (NF) treatment train in a dead-end filtration system for the treatment of raw manure. The objectives were to produce nutrient rich separate streams in reduced volumes and a particle and pathogen-free product water. MF removed TSS above 98% and the COD and phosphorus (P) retention were noticed above 60 and 80%, respectively, within a reduced MF concentrate volume, which accounted for 40% of the initial feed volume. The NF of MF permeate by NF270 showed most promising results by concentrating overall 50 and 70% of the total nitrogen (TN) and potassium (K) within a reduced NF concentrate volume, which accounted for 30% of the initial MF feed volume. Finally, the MF–NF treatment train of raw pig manure could produce a particle-free product water that can be reused in farms to wash barns, to irrigate nearby cultures, or can be applied to specific fields based on the demand.
Perceived Entrepreneurial Stress and Entrepreneurial Resilience; The Mediating Role of the Well-Being of Entrepreneurs and Moderating Role Perceived Online Social Support
Authors: Kipkosgei Felix
Published: January 2022

This study investigated the effect of perceived entrepreneurial stress on entrepreneurial resilience with the well-being of an individual entrepreneur in mediating role and perceived online social support moderating this relationship. Using survey data collected from 204 entrepreneurs in two major towns in Kenya, considered entrepreneurial hubs were analyzed. To uncover this relationship, confirmatory factor analysis was conducted to test the discriminant validity of the measurement model. Hierarchical multiple regression was used to test four hypotheses in seven models to estimate direct, indirect and interaction effects. The results showed that perceived entrepreneurial stress and the well-being of individual entrepreneurs are significantly negatively related; this study also found out that the well-being of individual entrepreneurs and entrepreneurial resilience are positively related. For moderation effect, perceived online social support positively moderated the relationship between the well-being of individual entrepreneurs and entrepreneurial resilience. Finally, to test the indirect effect, bootstrapping analysis was used to identify mediation effects. The bootstrapping indirect test results revealed that the well-being of individual entrepreneurs mediates the relationship between perceived entrepreneurial stress and entrepreneurial resilience. This study outlines online communities as an avenue where entrepreneurs can access online social support that can facilitate entrepreneurial resilience during crises and to foster resilience among entrepreneurs despite adversity, entrepreneurs need to consider making a culture of seeking and providing social support online to fellow entrepreneurs and online communities.
Production and Functional Properties of Graded Al-Based Syntactic Metal Foams
Authors: Károly Dóra , Iklódi Zsolt , Kemény Alexandra , Kincses Domonkos B. , Orbulov Imre N.
Published: January 2022

As cellular materials are gaining more ground in the automotive, airplane, and railway industries, the demand for functionally graded metal foams has appeared. In the case of syntactic metal foams, by changing the distribution of the filler material, the properties of the foams can be precisely adjusted according to the desired area of application. Several kinds of graded aluminum matrix syntactic foams (GMSFs) were fabricated with lightweight expanded clay aggregate particles and ceramic hollow spheres as filler materials. Their mechanical properties were observed by modal analysis and compression tests, supplemented with an accurate density determination by computer tomography measurements. The compressive properties were set up on a large scale by adjusting the density by adding specific amounts of Al particles to the filler. Based on the modal analysis results, simple averaging the density of GMSFs produces an inaccurate result in mode shapes and material parameters, so the varying density distributions should be taken into account. By simply varying the distribution of the filler material, we can modify the effective material properties of metal foams to better fit industrial requirements.
Determination of the Activation Energy for Hydride Decomposition Using a Sieverts-Type Apparatus and the Kissinger Equation
Authors: Song Myoung-Youp , Kwak Young-Jun
Published: January 2022

We developed a method to determine the activation energy for hydride decomposition using a Sieverts-type apparatus and the Kissinger equation, not using thermal analysis methods. The quantity of hydrogen released from the sample and the temperature of the reactor were first measured as a function of time at different heating rates (Φ) in a Sieverts-type apparatus. The dehydriding rates were calculated according to time and the temperature Tm (at which the dehydriding rate was the highest). Φ and Tm were then applied to the Kissinger equation. The dehydriding rate of Mg-5Ni samples obeyed a first-order law, and the Kissinger equation could thus be used to determine the activation energy. On a heating rate of 3 K/min, the decomposition rate of hydride was the highest at 590.0 K. From a plot of ln (Φ/Tm2) versus 1/Tm, the obtained activation energy for hydride decomposition was 174 kJ/mole.
Novel Bi-UWB on-Chip Antenna for Wireless NoC
Authors: Gaha Hafedh Ibrahim , Balti Moez
Published: January 2022

Communication between on-chip cores is a challenging issue for high-performance network-on-chip (NoC) design. Wireless NoC (WiNoC) represents an alternative design for planar wired interconnects, aiming to reduce latency and improve bandwidth. In this paper, a novel on-chip fractal antenna is designed and characterized. In order to disseminate interference affecting NoC performance in order to enhance on-chip quality of service (QoS), a set of exclusive sub-channels are assigned to each antenna. The proposed antenna has two wide bands (bi-WB)—B1 and B2, of (63–78) GHz and (101–157) GHz, respectively. The multi-band antenna allows different channel allocations for on-chip core communications. This WiNoC design exhibits improved performance, due to its enhanced antenna bandwidth and the benefit provided by the developed algorithm that can scan and compare to assign the best (upload or download) sub-channels to each antenna.
Effect of Inoculation Level on the Impact of the PGPR Azospirillum lipoferum CRT1 on Selected Microbial Functional Groups in the Rhizosphere of Field Maize
Authors: Renoud Sébastien , Abrouk Danis , Prigent-Combaret Claire , Wisniewski-Dyé Florence , Legendre Laurent , Moënne-Loccoz Yvan , Muller Daniel
Published: January 2022

The impact of inoculated plant growth-promoting rhizobacteria (PGPR) on its host physiology and nutrition depends on inoculum level. Whether the impact of the inoculated PGPR on the indigenous rhizosphere microbiota also varies with the PGPR inoculum level is unclear. Here, we tested this issue using the PGPR Azospirillum lipoferum CRT1—maize model system, where the initial seed inoculation is known to enhance maize growth and germination, and impacts the maize rhizomicrobiota, including microbial functional groups modulating plant growth. A. lipoferum CRT1 was added to the seeds at standard (105–6 cells.seed−1) or reduced (104–5 cells.seed−1) inoculation levels, in three fields. The effect of the two PGPR formulations was assessed on maize growth and on the nifH (nitrogen fixation), acdS (ACC deaminase activity) and phlD (2,4-diacetylphloroglucinol production) microbial functional groups. The size of the three functional groups was monitored by qPCR at the six-leaf stage and the flowering stage, and the diversity of the nifH and acdS functional groups (as well as the bacterial community) were estimated by MiSeq metabarcoding at the six-leaf stage. The results showed that the benefits of the reduced inoculant formulation were significant in two out of three fields, but different (often lower) than those of the standard formulation. The effects of formulations on the size of the three functional groups differed, and depended on field site and functional group. The reduced formulation had an impact on the diversity of nifH and acdS groups at one site, whereas the standard formulation had an impact at the two other sites. Inoculation significantly impacted the total bacterial community in the three fields, but only with the reduced formulation. In conclusion, the reduced inoculant formulation impacted the indigenous rhizosphere microbiota differently, but not less efficiently, than the standard formulation.
Dominican Larimar Mining—Current State and Future Prospects
Authors: Broda Krzysztof , Natkaniec-Nowak Lucyna , Rak Zbigniew , Stasica Jerzy , Heflik Wiesław , Mościcki Jerzy , Peña Miguel , Muñoz Rolando , George Carlos
Published: January 2022

This paper presents basic mineralogical and petrological data of the rocks hosting larimar deposit from the Sierra de Bahoruco, in the SW part of the Dominican Republic. Larimar is a unique ornamental stone with a wealth of decorative qualities. The Las Filipinas Larimar Mine in Barahona Province is the only place of this type in the world. Its production and distribution require radical action; hence, the paper also provides current information on the extraction of this raw material and prospects for the future. The paper indicates the possibility of using a new adit support system based on a mixed support (arch support and shotcrete). Numerical analysis shows the need to create a shotcrete coating around the entire circumference, about 15 cm thick. The variable geotechnical situation around the excavation, caused by the planned operation, prompts the use of slightly different solutions in the field of support. The article presents an outline of the technology using Polish experience. It is a support-bolt casing system with the latest achievements in this field.
Fabrication of Hydrotalcite-like Copper Hydroxyl Salts as a Photocatalyst and Adsorbent for Hexavalent Chromium Removal
Authors: Chuaicham Chitiphon , Sekar Karthikeyan , Balakumar Vellaichamy , Zhang Li , Trakulmututa Jirawat , Smith Siwaporn Meejoo , Sasaki Keiko
Published: January 2022

Cu-HyS-urea and Cu-HyS-NaOH, which are hydrotalcite-like copper hydroxyl salts, were prepared by two different methods, urea hydrolysis and precipitation, respectively. Both synthesis methods provided the successful formation of a copper hydroxyl salt, Cu2(OH)3NO3. From XRD and UV-DRS results, the product from the urea hydrolysis methods (Cu-HyS-urea) displayed higher crystallinity, small bandgap energy (Eg), and high light absorption ability because of some intercalated carbonate anions. For the Cr(VI) removal test, the Cu-HyS-NaOH showed superior adsorption of Cr(VI) than Cu-HyS-urea due to a higher specific surface area, confirmed by BET analysis. However, the Cu-HyS-urea presented higher photocatalytic Cr(VI) reduction under light irradiation than Cu-HyS-NaOH, owing to narrow Eg, less recombination, and a high transfer of the photogenerated charge carriers, proven by the results from photoluminescence, photocurrent density, and electrochemical impedance spectroscopy. Thus, this work provides a new function of the hydrotalcite-like copper hydroxyl salts (Cu-HyS-urea and Cu-HyS-NaOH) that can be utilized not only for adsorption of Cr(VI) but also as photocatalysts for Cr(VI) reduction under light irradiation.
Effects of Co Doping on the Growth and Photocatalytic Properties of ZnO Particles
Authors: Tang Lanqin , Jia Yin , Zhu Zhishang , Hua Yue , Wu Jun , Zou Zhigang , Zhou Yong
Published: January 2022

The present work reports on the synthesis of ZnO photocatalysts with different Co-doping levels via a facile one-step solution route. The structural and optical properties were characterized by powder X-ray diffraction (XRD), field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), energy dispersive spectroscopy (EDS), and UV-Vis diffuse reflectance spectra. The morphology of Co-doped ZnO depends on the reaction temperature and the amount of Co and counter-ions in the solution. Changes with the c-axis lattice constant and room temperature redshift show the replacement of Zn with Co ions without changing the wurtzite structure. Photocatalytic activities of Co-doped ZnO on the evolution of H2 and the degradation of methylene blue (MB) reduce with the doping of Co ions. As the close ionic radii of Co and Zn, the reducing photocatalytic activity is not due to the physical defects but the formation of deep bandgap energy levels. Photocurrent response experiments further prove the formation of the recombination centers. Mechanistic insights into Co-ZnO formation and performance regulation are essential for their structural adaptation for application in catalysis, energy storage, etc.
Spherical Sampler Probes Enhance the Robustness of Ambient Ionization Mass Spectrometry for Rapid Drugs Screening
Authors: Shamraeva Mariya A. , Bormotov Denis S. , Shamarina Ekaterina V. , Bocharov Konstantin V. , Peregudova Olga V. , Pekov Stanislav I. , Nikolaev Eugene N. , Popov Igor A.
Published: January 2022

Ambient ionization mass spectrometry has become one of the most promising approaches for rapid and high-throughput screening of small molecules in complex biological matrices for emergency medicine, forensics, and food and agriculture applications. The simple procedures for sample collection and ionization without additional pretreatment are vital in these fields. Many efforts have been devoted to modifying various ambient ionization techniques to simplify the procedures and improve the robustness and sensitivity of the methods. Here, we demonstrate the implementation of rigid spherical sampler probes to improve the robustness of touch spray ionization mass spectrometry. The sphericity of the probes increases the stability of the cone-jet mode of electrospray, reduces the requirements for fine positioning of a sampler in the ion source, and decreases the possibility of corona discharge occurrence. The utilization of spherical sampler probes allows fast, non-invasive sampling, followed by rapid analysis for various drugs of different chemical classes in complex biological matrices, such as the whole blood or sebum collected from the skin surface. The linearity of the analytical signal response from drug concentration confirms the possibility of creating a simple semiquantitative method for small molecules monitoring using spherical sampler probes.
Artificial Solar Light-Driven APTES/TiO2 Photocatalysts for Methylene Blue Removal from Water
Authors: Sienkiewicz Agnieszka , Rokicka-Konieczna Paulina , Wanag Agnieszka , Kusiak-Nejman Ewelina , Morawski Antoni W.
Published: January 2022

A visible-light photocatalytic performance of 3-aminopropyltriethoxysilane (APTES)-modified TiO2 nanomaterials obtained by solvothermal modification under elevated pressure, followed by calcination in an argon atmosphere at 800–1000 °C, is presented for the first time. The presence of silicon and carbon in the APTES/TiO2 photocatalysts contributed to the effective delay of the anatase-to-rutile phase transformation and the growth of the crystallites size of both polymorphous forms of TiO2 during heating. Thus, the calcined APTES-modified TiO2 exhibited higher pore volume and specific surface area compared with the reference materials. The change of TiO2 surface charge from positive to negative after the heat treatment increased the adsorption of the methylene blue compound. Consequently, due to the blocking of active sites on the TiO2 surface, the adsorption process negatively affected the photocatalytic properties. All calcined photocatalysts obtained after modification via APTES showed a higher dye decomposition degree than the reference samples. For all 3 modifier concentrations tested, the best photoactivity was noted for nanomaterials calcined at 900 °C due to a higher specific surface area than materials calcined at 1000 °C, and a larger number of active sites available on the TiO2 surface compared with samples annealed at 800 °C. It was found that the optimum concentration for TiO2 modification, at which the highest dye decomposition degree was noted, was 500 mM.
Negative Modulation of the Angiogenic Cascade Induced by Allosteric Kinesin Eg5 Inhibitors in a Gastric Adenocarcinoma In Vitro Model
Authors: Ricci Alessia , Gallorini Marialucia , Del Bufalo Donatella , Cataldi Amelia , D’Agostino Ilaria , Carradori Simone , Zara Susi
Published: January 2022

Eg5 is a kinesin essential in bipolar spindle formation, overexpressed in tumours, thus representing a new target in cancer therapy. We aimed at evaluating the anti-cancer activity of Eg5 thiadiazoline inhibitors 2 and 41 on gastric adenocarcinoma cells (AGS), focusing on the modulation of angiogenic signalling. Docking studies confirmed a similar interaction with Eg5 to that of the parent compound K858. Thiadiazolines were also tested in combination with Hesperidin (HSD). Cell cycle analysis reveals a reduction of G1 and S phase percentages when 41 is administered as well as HSD in combination with K858. Western blot reveals Eg5 inhibitors capability to reduce PI3K, p-AKT/Akt and p-Erk/Erk expressions; p-Akt/Akt ratio is even more decreased in HSD+2 sample than the p-Erk/Erk ratio in HSD+41 or K858. VEGF expression is reduced when HSD+2 and HSD+41 are administered with respect to compounds alone, after 72 h. ANGPT2 gene expression increases in cells treated with 41 and HSD+2 compared to K858. The wound-healing assay highlights a reduction in the cut in HSD+2 sample compared to 2 and HSD. Thus, Eg5 inhibitors appear to modulate angiogenic signalling by controlling VEGF activity even better if combined with HSD. Overall, Eg5 inhibitors can represent a promising starting point to develop innovative anti-cancer strategies.
Cancer Cytotoxicity of a Hybrid Hyaluronan-Superparamagnetic Iron Oxide Nanoparticle Material: An In-Vitro Evaluation
Authors: Chang Yen-Lan , Liao Pei-Bang , Wu Ping-Han , Chang Wei-Jen , Lee Sheng-Yang , Huang Haw-Ming
Published: January 2022

While hyaluronic acid encapsulating superparamagnetic iron oxide nanoparticles have been reported to exhibit selective cytotoxicity toward cancer cells, it is unclear whether low-molecular-weight hyaluronic acid-conjugated superparamagnetic iron oxide nanoparticles also display such cytotoxicity. In this study, high-molecular-weight hyaluronic acid was irradiated with γ-ray, while Fe3O4 nanoparticles were fabricated using chemical co-precipitation. The low-molecular-weight hyaluronic acid and Fe3O4 nanoparticles were then combined according to a previous study. Size distribution, zeta potential, and the binding between hyaluronic acid and iron oxide nanoparticles were examined using dynamic light scattering and a nuclear magnetic resonance spectroscopy. The ability of the fabricated low-molecular-weight hyaluronic acid conjugated superparamagnetic iron oxide nanoparticles to target cancer cells was examined using time-of-flight secondary ion mass spectrometry and T2* weighted magnetic resonance images to compare iron signals in U87MG human glioblastoma and NIH3T3 normal fibroblast cell lines. Comparison showed that the present material could target U87MG cells at a higher rate than NIH3T3 control cells, with a viability inhibition rate of 34% observed at day two and no cytotoxicity observed in NIH3T3 normal fibroblasts during the three-day experimental period. Supported by mass spectrometry images confirming that the nanoparticles accumulated on the surface of cancer cells, the fabricated materials can reasonably be suggested as a candidate for both magnetic resonance imaging applications and as an injectable anticancer agent.
Preparation and Characterization of Electrospun Polysaccharide FucoPol-Based Nanofiber Systems
Authors: Vázquez-González Yuliana , Prieto Cristina , Stojanovic Milan , Torres Cristiana A. V. , Freitas Filomena , Ragazzo-Sánchez Juan Arturo , Calderón-Santoyo Montserrat , Lagaron Jose M.
Published: January 2022

The electrospinnability of FucoPol, a bacterial exopolysaccharide, is presented for the first time, evaluated alone and in combination with other polymers, such as polyethylene oxide (PEO) and pullulan. The obtained fibers were characterized in terms of their morphological, structural and thermal properties. Pure FucoPol fibers could not be obtained due to FucoPol’s low water solubility and a lack of molecular entanglements. Nanofibers were obtained via blending with PEO and pullulan. FucoPol:PEO (1:3 w/w) showed fibers with well-defined cylindrical structure, since the higher molecular weight of PEO helps the continuity of the erupted jet towards the collector, forming stable fibers. WAXS, DSC and TGA showed that FucoPol is an amorphous biopolymer, stable until 220 °C, whereas FucoPol-PEO fibers were stable until 140 °C, and FucoPol:pullulan fibers were stable until 130 °C. Interestingly, blended components influenced one another in intermolecular order, since new peaks associated to intermolecular hierarchical assemblies were seen by WAXS. These results make FucoPol-based systems viable candidates for production of nanofibers for packaging, agriculture, biomedicine, pharmacy and cosmetic applications.
Ultrathin Stretchable All-Fiber Electronic Skin for Highly Sensitive Self-Powered Human Motion Monitoring
Authors: Shi Yapeng , Ding Tianyi , Yuan Zhihao , Li Ruonan , Wang Baocheng , Wu Zhiyi
Published: January 2022

Advances in the technology of wearable electronic devices have necessitated much research to meet their requirements, such as stretchability, sustainability, and maintenance-free functioning. In this study, we developed an ultrathin all-fiber triboelectric nanogenerator (TENG)-based electronic skin (TE-skin) with high stretchability, using electrospinning and spraying, whereby the silver nanowire (Ag NW) electrode layer is deposited between two electrospinning thermoplastic polyurethane (TPU) fibrous layers. Due to its extraordinary stretchability and prominent Ag NW conductive networks, the TE-skin exhibits a high sensitivity of 0.1539 kPa−1 in terms of pressure, superior mechanical property with a low-resistance electrode of 257.3 Ω at a strain of 150%, great deformation recovery ability, and exceptional working stability with no obvious fluctuation in electrical output before and after stretching. Based on the outstanding performances of the TE-skin, an intelligent electronic glove was fabricated to detect multifarious hand gestures. Moreover, the TE-skin has the potential to record human motion for real-time physiological signal monitoring, which provides promising applications in the fields of flexible robots, human-machine interaction, and multidimensional sports monitoring in next-generation electronics.
Herbals and Plants in the Treatment of Pancreatic Cancer: A Systematic Review of Experimental and Clinical Studies
Authors: Triantafillidis John K. , Triantafyllidi Eleni , Sideris Michail , Pittaras Theodoros , Papalois Apostolos E.
Published: January 2022

Background: Pancreatic cancer represents the most lethal malignancy among all digestive cancers. Despite the therapeutic advances achieved during recent years, the prognosis of this neoplasm remains disappointing. An enormous amount of experimental (mainly) and clinical research has recently emerged referring to the effectiveness of various plants administered either alone or in combination with chemotherapeutic agents. Apart from Asian countries, the use of these plants and herbals in the treatment of digestive cancer is also increasing in a number of Western countries as well. The aim of this study is to review the available literature regarding the efficacy of plants and herbals in pancreatic cancer. Methods: The authors have reviewed all the experimental and clinical studies published in Medline and Embase, up to June 2021. Results: More than 100 plants and herbals were thoroughly investigated. Favorable effects concerning the inhibition of cancer cell lines in the experimental studies and a favorable clinical outcome after combining various plants with established chemotherapeutic agents were observed. These herbals and plants exerted their activity against pancreatic cancer via a number of mechanisms. The number and severity of side-effects are generally of a mild degree. Conclusion: A quite high number of clinical and experimental studies confirmed the beneficial effect of many plants and herbals in pancreatic cancer. More large, double-blind clinical studies assessing these natural products, either alone or in combination with chemotherapeutic agents should be conducted.