bluuebunny/crossref_metadata_2025 huggingface dataset:
The Developmental Participation Skills Assessment: Development and Content Validation
Authors: Fuller Kristy , DeWolfe Tara , Coughlin Mary
Published: March 2023

Purpose:The Developmental Participation Skills Assessment (DPS) is designed to assist clinicians who work with hospitalized infants in thoughtfully and accurately identifying infant readiness and the capacity for an infant’s participation during caregiving interactions as well as offering an opportunity for the caregiver(s) to reflect upon the experience. Non-contingent caregiving impairs an infant’s autonomic, motor and state stability which interferes with regulation and negatively impacts neurodevelopment. By providing an organized way to assess readiness for care and capacity to participate in care, the infant may experience less stress and trauma. The DPS is completed by the caregiver following any caregiving interaction.Methods:Following a literature review, the development of the DPS items were extrapolated from well-established tools to achieve the most evidence-based criteria. Following item inclusion generation, the DPS went thru five phases of content validation: (a) Initial tool development and use by five NICU professionals as part of their developmental assessment. Expansion of the use of the DPS to include three more hospital NICUs within the health system (b) Item adjustment and use as part of a bedside training program at a Level IV NICU (c) Focus group of professionals using the DPS provided feedback and scoring was added (d) Pilot of DPS by multidisciplinary focus group in a Level IV NICU (e) Feedback form sent to 20 NICU experts and content of DPS finalized with reflective portion added.Main Outcome Variable:The establishment of an observational instrument, the Developmental Participation Skills Assessment, provides a means for identifying infant readiness, assessing the quality of infant participation, and prompting clinician reflective processing.Results:A total of 50 professionals across the Midwest (4 OT, 2 PT, 3 SLP, 41 nurses) utilized the DPS as a part of standard practice throughout the phases of development. Assessments were completed on both full-term and preterm hospitalized infants. Professionals within these phases utilized the DPS with infants within a wide range of adjusted gestational ages from 23 weeks to 60 weeks (20 weeks post term). Infants ranged in severity from breathing room air to being intubated on a ventilator. After all phases of development and expert panel feedback, with an additional 20 neonatal experts, the final result was the formation of an easy-to-use observational tool for assessing infant readiness prior to caregiving, participation during caregiving, and stability following caregiving. In addition, there is the opportunity for the clinician to reflect following the caregiving interaction in a concise, consistent way.Conclusion:Identifying readiness, and assessing the quality of the infant’s experience while also prompting clinician reflection following the experience has the potential to reduce toxic stress for the baby and promote mindfulness and contingency in caregiving.
Step 3: Critically Appraising Evidence: Systematic Review or Metasynthesis of Qualitative Studies
Authors: Bell Susan Givens
Published: March 2023

Critical appraisal of the evidence is the third step in the evidence-based practice (EBP) process. Many questions in nursing cannot be answered using quantitative methods. We often desire a better understanding of people’s lived experiences. In the NICU, these questions may be related to the experiences of families or staff. Qualitative research can provide a deeper understanding of lived experiences. This column, the fifth in a multipart series describing the critical appraisal process focuses on the critical appraisal of a systematic review of qualitative studies.
Fragmentos de un pasado olvidado: la escalera jeroglífica II de El Resbalón
Authors:   Universidad Nacional Autónoma de México - Instituto de Investigaciones Filológicas, Centro de Estudios Mayas, Esparza Olguín Octavio Quetzalcóatl
Published: March 2023

Durante el periodo de 1973 a 1978, los arqueólogos Gary Rex Walters y William Purifoy llevaron a cabo diversas temporadas de campo en el sitio arqueológico de El Resbalón, Quintana Roo, que redundaron en el descubrimiento de tres escaleras jeroglíficas asociadas a sendas estructuras erigidas en el Grupo Principal, conjunto arquitectónico de mayores dimensiones dentro del asentamiento. El hallazgo tuvo lugar después de los reportes que ambos arqueólogos recibieron en 1972, sobre la existencia de una estructura con piedras grabadas en un sitio ubicado al poniente de Bacalar. De particular interés resultó el hallazgo de las escalinatas I y III debido a lo extenso de sus textos jeroglíficos, de los más amplios registrados hasta ahora en la región del sur de Quintana Roo, que fueron esculpidos en varias decenas de bloques pétreos. Si bien, en la actualidad, no existe un registro íntegro de dichas escalinatas, diversos investigadores han realizado análisis de diferentes secciones relacionadas con gobernantes de la afamada dinastía Kaanu’l, así como con eventos vinculados a fechas de Cuenta Larga que pueden reconstruirse de forma certera y que corresponden al periodo Clásico Temprano. Sin embargo, este no es el caso de la Escalera Jeroglífica II, que ha pasado desapercibida en la literatura académica desde su descubrimiento en el año de 1978.
Praca na własny rachunek w świetle literatury — podejście terminologiczne
Authors: Pancer-Cybulska Ewa
Published: March 2023

Terminy „praca na własny rachunek” i „samozatrudnienie” są często stosowane jako synonimy. Artykuł wskazuje na różnice znaczeniowe tych pojęć, a także na rozmaite sposoby ich definiowania. Autorka przywołuje liczne definicje proponowane przez naukę, polską i zagraniczną literaturę przedmiotu oraz podawane w aktach prawa krajowego i międzynarodowego. Z uwagi na ewolucję współczesnych form pracy opisane zostały też zjawiska networkingu, zatrudnienia hybrydowego i inne formy samozatrudnienia zyskujące popularność w ostatnich latach, zwłaszcza w sektorze gospodarki cyfrowej. Opracowanie prezentuje obfitość źródeł i poglądów badaczy, analizujących pracę na własny rachunek jako ważny element współczesnej gospodarki.
Program complex for modelling a manipulating robot
Authors: Rain Thu
Published: March 2023

The article proposes the development of a software module for modeling the kinematics and dynamics of a manipulator with five degrees of freedom. To solve the forward kinematics problem of the manipulator, the Denavit–Hartenberg method was used. To solve the inverse kinematics and dynamics problem of the manipulator, analytical methods (the Levenberg-Marquardt method, the Newton–Euler method) and a soft computing method (adaptive neurofuzzy inference system) were used. The software module for modeling the kinematics and dynamics of the manipulator was developed using the software package of the SolidWorks computer-aided design system and the MatLab program. The developed software module is able to simulate the kinematics and dynamics of the manipulator based on the described methods, visualize the simulation results, generate a trajectory for the target position and orientation of the end-effector of the manipulator, simulate the movement of the manipulator along a given trajectory.
La creación de precedentes interpretativos
Authors: Ramírez-Ludeña Lorena
Published: March 2023

Los precedentes vinculantes verticalmente son a menudo rechazados en la tradición del civil law a partir de tres argumentos interrelacionados: (1) los jueces no crean derecho, simplemente lo aplican; (2) los jueces están obligados por las leyes, no por las decisiones de otros jueces; (3) las leyes, no las decisiones judiciales que las interpretan y aplican, son fuentes del derecho. El texto aborda separadamente los tres argumentos sosteniendo que los precedentes pueden tener fuerza vinculante y ser fuentes del derecho incluso en países donde su propia existencia es muy cuestionada. Primero, se argumenta que los jueces de los tribunales superiores realizan una importante actividad creativa cuando interpretan la normativa, por lo que podemos hablar de precedentes genuinos que rigen la interpretación, que agregan algo nuevo al derecho. En segundo lugar, se muestra que la fuerza vinculante de los precedentes en países de tradición continental puede ser bastante robusta, especialmente cuando se los compara con sistemas en los que se acepta su carácter vinculante de manera generalizada. La parte final discute hasta qué punto los precedentes que interpretan el derecho pueden ser considerados fuentes del derecho.
Sanciones penales y corrupción. Una aproximación desde la legitimidad empresarial
Authors: López Lorca Beatriz
Published: March 2023

Ante el agotamiento de la pena de multa como sanción clásica de la persona jurídica, se hace preciso repensar una penología de la persona jurídica desde una nueva perspectiva. El concepto de legitimidad empresarial ofrece un nuevo horizonte hacia el que orientar estas sanciones. Esto se hace especialmente relevante en casos como la corrupción, donde una verdadera reparación del daño o el efecto preventivo de la sanción son difíciles de alcanzan mediante una mera responsabilidad penal de carácter económico. A continuación, se presenta una breve reflexión sobre estos aspectos.
Natalia Torres Zúñiga, The Inter American Court of Human Rights. The Legitimacy of International Courts and Tribunals
Authors: León Vásquez Jorge Luis
Published: March 2023

Este articulo reseña: Natalia Torres Zúñiga, The Inter American Court of Human Rights. The Legitimacy of International Courts and Tribunals. (2022) Routledge, London-New York, 213 pp.
Prevalencia de alveolitis seca asociada a urgencias dolorosas durante el aislamiento social preventivo y obligatorio de la pandemia COVID-19 en un servicio de urgencias del área bonaerense metropolitana en la República Argentina
Authors: Cesar Gatti Patricio , Ezequiel Hilber , Clara Bellia María , Clara Bellia María , Montes de Oca Hernan , Santucci Victoria , Gualtieri Ariel , Prada Silvio , Puia Sebastián Ariel
Published: March 2023

Objetivo: Evaluar la prevalencia de alveolitis seca como complicación postquirúrgica, cuando existió dolor intenso local en el preoperatorio, durante el Aislamiento Social Preventivo y Obligatorios (ASPO) de la pandemia COVID-19 en la República Argentina. Material y Métodos: Se realizó un estudio descriptivo en el que fueron incluidos 1209 pacientes, que presentaron indicación de exodoncia y concurrieron al servicio de urgencias y orientación de pacientes de la Facultad de Odontología de la universidad de Buenos Aires, durante el ASPO en un periodo comprendido entre el 20 de marzo y el 20 de junio de 2020, con dolor agudo e intenso en el sitio quirúrgico. La presencia de alveolitis seca fue asociada de forma exploratoria con las variables edad, sexo, tabaquiamo y medicación de uso crónico. Resultados: Fueron operados 1209 pacientes a los que se les realizaron un total de 1372 exodoncias, con un promedio de edad 41 años. La prevalencia fue de 1,06%. Conclusión: La prevalencia de alveolitis seca fue del 1%, no siendo superior a otras experiencias donde no se consideró al dolor como una condición previa a la exodoncia.
The Effect of Binahong (Anredera cordifolia (Ten.) Steenis) Leaf Ethanolic Extract on the Reduction of Blood Uric Acid Levels in Hyperuricemic Male White Wistar Rats (Rattus norvegicus)
Authors: Anugerah Panji , Rahman Safrizal
Published: March 2023

Highlights:

Antioxidant flavonoid compounds can be found in binahong leaf extract.
Binahong leaf extract is as effective as allupurinol in reducing uric acid levels.

Abstract:
Binahong (Anredera cordifolia (Ten.) Steenis) is empirically used to treat burns, rheumatism, gout, typhoid, and stroke. Binahong leaves contain flavonoids that have an antioxidant effect. This study aimed to identify and test binahong leaf flavonoid compounds’ antioxidant properties in reducing uric acid levels. This study began by producing binahong leaf extract and then identifying the flavonoid content with a phytochemical test. The results indicated that the binahong leaf extract contained antioxidant flavonoid compounds. The data were followed by testing flavonoid activity in lowering uric acid levels. This study used male white Wistar rats, of which the uric acid was induced by chicken liver juice. The animals used in the test were 25 rats divided into five groups (i.e., negative control group, positive control group, and treatment groups with dose I, dose II, and dose III). In each group, there were five male white rats. This study was a laboratory experiment using a pre-test post-test design with control groups (pre-test post-test control group design), where the grouping was done based on a randomized group design. By using statistical tests, the results obtained showed that there was a significant decrease of uric acid levels in the positive control group and the treatment group. In conclusion, binahong leaf ethanolic extract can reduce blood uric acid levels induced by chicken liver juice in male white Wistar rats.
The Impact of Social Stigma on Child Patients with Cleft Lip and Palate
Authors: Ariani Yuni , Astarini Diska
Published: March 2023

Highlights:1. Awareness of social stigma impact on children with cleft lip and palate is lacking in various areas.2. Identifying social stigma's influence on children with cleft lip is important to help surgeons prioritize resource allocation and provide further evidence in incorporating quality of life.
Abstract:Social rejection still happens to a large number of children who have cleft lip and palate. Stigma has a detrimental impact on children with cleft in the aspects of education, employment, marriage, and community acceptance, which can be exacerbated by barriers to high-quality child care. A literature study related to this topic was conducted by searching for articles from 2018 to October 2021 through three databases (i.e., PubMed, Embase, and Medline). The term used for the literature search was "cleft", which generated results that were sorted alphabetically and by relevance. This yielded 15 articles that focused on social stigma’s influence on cleft lip and palate patients. In conclusion, the articles generally reported that the awareness of social stigma impacts on children with cleft lip and palate are lacking in various areas. It is important to identify social stigma’s influence on children with cleft lip. This can help surgeons prioritize resource allocation and provide further evidence in incorporating quality of life measures into the treatment outcome assessment.
The Use of STRONGkids, Total Lymphocyte Count, and Serum Albumin to Identify the Risk of Hospital Malnutrition in Children
Authors: Rusti Hafiza Amadhin , Widjaja Nur Aisiyah , Irawan Roedi , Setiawan Ariandi
Published: March 2023

Highlights:

Medium- and high-risk STRONGkids scores are related with low total lymphocyte count and serum albumin, which are related to hospital malnutrition, albeit indirectly.
The use of STRONGkids with total lymphocyte count and serum albumin can detect the risk of hospital malnutrition in children.

 
Abstract:
Hospital malnutrition occurs in hospitalized patients who do not consume enough food while their nutritional requirements increase. It occurs particularly in children who have undergone gastrointestinal surgery. Despite the lack of a universal instrument for detecting hospital malnutrition, various parameters can be considered to assist in its identification. STRONGkids has demonstrated its efficiency in detecting malnutrition risk in children. Total lymphocyte count (TLC) and serum albumin are biochemical markers that are related to infection and protein leakage, which can worsen hospital malnutrition. The research objective was to analyze the correlation between STRONGkids and biochemical markers (TLC, serum albumin) to identify hospital malnutrition in children who underwent gastrointestinal surgery. This was a retrospective cross-sectional observational study utilizing medical records. The statistical analysis was conducted using SPSS 21. This study included 37 subjects, with a 24.32% hospital malnutrition incidence rate. The subjects were divided into two groups: hospital malnutrition (n=9) and non-hospital malnutrition (n=28). The STRONGkids of both groups at admission demonstrated a significant difference, while the albumin and TLC did not. The significantly different STRONGkids scores of both groups at admission correlated negatively with the length of hospital stay (LOS), body weight reduction, TLC, and albumin. Those parameters also did not correlate with hospital malnutrition. However, hospital malnutrition increased the risk of low albumin and TLC at discharge by 2.951 and 5.549 times, respectively. In conlusion, TLC and serum albumin cannot be used as independent markers for hospital malnutrition, but STRONGkids can be used in conjunction with TLC and serum albumin to identify hospital malnutrition risk.
The Community Attitudes And Behavior Towards People Living With Mental Illness: A Descriptive Study
Authors: Ana Kartika Febry
Published: March 2023

Introduction: Mental health is still a significant problem in the world, because health is not only seen as free from disease but also includes all aspects of human life, physical, emotional, social and spiritual. The purpose of this study is to describe the attitudes and behavior of individuals in patients with mental disorders in the community.
Method: This study used a quantitative descriptive design. The population in this study were people in three RWs in one urban village of Surakarta with a total of 4,465 people. The sample used in this study was 99 respondents using a simple random sampling. The analysis used is univariate analysis with a central tendency. The instrument used individual characteristics, attitudes and behavior towards mental patients
Results: Based on the results of research on 99 respondents, it was found that the characteristics of the majority of respondents were female (64,6%), age 36-45 years (38,4%), being high school education level (53,5%) and the majority working as laborers (23,2%). The attitude of respondents to patients with mental disorders is negative or less supportive (52,52%), while the behavior of respondents to patients with mental disorders is considered less good (79,8%).
Conclusions: The community still had negative attitude and poor behavior toward people living with mental illness. This result indicated the need for intervention and promotion about mental illness in the community setting.
Traditional Ritual to Cure Mental Illness According to Manggarai Culture in East Nusa Tenggara
Authors: Daulima Novy Helena Catharina , Eka Angelina
Published: March 2023

Introduction: Mental illness treatment using traditional methods is still carried out in various regions in Indonesia, including in the Manggarai regency, East Nusa Tenggara. The aim of this study is to describe the types of traditional rituals performed to cure mental illness in Manggarai culture.
Methods: This study uses an ethnographic approach which is supported by a qualitative descriptive approach. Data were collected by conducting in-depth interviews with 10 cultural leaders.
Results: This study identified 4 types of rituals in treating mental illness namely peler rituals to cure mental illness due to being possessed by evil spirits, keti manuk neni rituals to cure mental illness due to heredity, Teing hang ritual heals mental illness due to ungratefulness to ancestors, and the oke dara ta'a ritual to heals mental illness due to having black magic.
Conclusion: The results of the study indicate that there are still many people who practice traditional healing practices for people with mental illnesses and neglect medical treatment, resulting in relapses that lead to pasung or physical restraint and confinement of people with mental illnesses. Therefore, in providing education and promoting mental health in the community, it is necessary to emphasize the effectiveness of medical treatment.
Post-Traumatic Stress Disorder (PTSD) Among Landslide Survivors: a Descriptive Study
Authors: Cahyani Hanif Eka , Warsini Sri , Raymomdalexas Carla Marchira
Published: March 2023

Introduction: Natural disasters cause many problems for survivors. Trauma, one such outcome of disasters, may result in the development of post traumatic stress disorder (PTSD). This study aimed to identify the level of post traumatic stress disorder (PTSD) and also its predictor factors among survivors of a landslide disaster at Donorati Village community, Purworejo, Indonesia
Method: This was a descriptive cross-sectional design research using a quantitative approach. The population of this study were the landslide survivors in Purworejo district. While this research sample was 100 survivors who live in Donorati village. Cluster and consecutive sampling techniques was applied for this study. The variables of this study were PTSD, gender, age, education level, socio-economic status based on occupation, marriage status, severity of natural disaster, exposure to previous disaster events, landslide disaster impact (house damage, injured family members, and death of family members) and evacuation record.  The instruments of this research were demographic form and The Impact of Event Scale-Revised (IES-R). Bivariate analysis was performed using Chi-squared test and Fisher’s test, followed by multivariate analysis using logistic regression.
Results: The prevalence of probability of PTSD participants was 27%. Bivariate analysis revealed significant differences in PTSD levels based on sex (p-value = 0,02), age (p-value = 0,009), occupation (p-value = 0,02), severity of disaster (p-value = 0,008), the presence of injured family members (p-value = 0,018), and evacuation history (p-value = 0,001). The multivariate analysis revealed the factors related to PTSD after the landslide as gender and severity of the disaster impact.
Conclusions: The level of PTSD was significantly different based on gender, age, occupation, severity of the disaster, the presence of injured family members, and a history of evacuation. Mental health and psychosocial support services need to be developed to help reduce the impact of disasters and to assist survivors to cope better with the outcomes of those events.
Decentralized tracking control design based on intelligent critic for an interconnected spring-mass-damper system
Authors: Fan Wenqian , Liu Ao , Wang Ding
Published: March 2023

In this paper, the decentralized tracking control (DTC) problem is investigated for a class of continuous-time nonlinear systems with external disturbances. First, the DTC problem is resolved by converting it into the optimal tracking controller design for augmented tracking isolated subsystems (ATISs). %It is investigated in the form of the nominal system. A cost function with a discount is taken into consideration. Then, in the case of external disturbances, the DTC scheme is effectively constructed via adding the appropriate feedback gain to each ATIS. %Herein, we aim to obtain the optimal control strategy for minimizing the cost function with discount. In addition, utilizing the approximation property of the neural network, the critic network is constructed to solve the Hamilton-Jacobi-Isaacs equation, which can derive the optimal tracking control law and the worst disturbance law. Moreover, the updating rule is improved during the process of weight learning, which removes the requirement for initial admission control. Finally, through the interconnected spring-mass-damper system, a simulation example is given to verify the availability of the DTC scheme.
Linking processing parameters with melt pool properties of multiple nickel-based superalloys via high-dimensional Gaussian process regression
Authors: Menon Nandana , Mondal Sudeepta , Basak Amrita
Published: March 2023

A physics-based model is used to predict the melt pool properties in the laser-directed energy deposition of several nickel-based superalloys for different process parameters. The input space is high-dimensional, consisting of a common 19-dimensional composition space for each alloy and the process parameters (laser power and scan velocity). Gaussian Process-based regression frameworks are developed by training surrogates on data generated by a validated analytical model. These surrogates are thereafter used to predict and define relationships between the composition, resultant thermophysical properties, process parameters, and the subsequent melt pool property. The probabilistic predictions are augmented by uncertainty quantification and sensitivity analysis to substantiate the findings further.
When to Use Large Language Model: Upper Bound Analysis of BM25 Algorithms in Reading Comprehension Task
Authors: Liu Tingzhen , Xiong Qianqian , Zhang Shengxi
Published: March 2023

Large language model (LLM) is a representation of a major advancement in AI, and has been used in multiple natural language processing tasks. Nevertheless, in different business scenarios, LLM requires fine-tuning by engineers to achieve satisfactory performance, and the cost of achieving target performance and fine-tuning may not match. Based on the Baidu STI dataset, we study the upper bound of the performance that classical information retrieval methods can achieve under a specific business, and compare it with the cost and performance of the participating team based on LLM. This paper gives an insight into the potential of classical computational linguistics algorithms, and which can help decision-makers make reasonable choices for LLM and low-cost methods in business R&D.
A Proposed Model of Xeno-Keratoplasty Using 3D Printing and Decellularization
Authors: Wang Xinyu , Elbahrawi Rawdah , Abdukadir Azhar Mohamud , Ali Zehara Mohammed , Corridon Peter
Published: March 2023

Corneal opacity is a leading cause of vision impairment and suffering worldwide. Transplantation can effectively restore vision and reduce chronic discomfort. However, there is a considerable shortage of viable corneal graft tissues. Tissue engineering may address this issue by advancing xeno- keratoplasty as a viable alternative to conventional keratoplasty. In particular, livestock decellularization strategies offer the potential to generate bioartificial ocular prosthetics in sufficient supply to match existing and projected needs. To this end, we have examined the best practices and characterizations that have supported the current state-of-the-art driving preclinical and clinical applications. Identifying the challenges that delimit activities to supplement the donor corneal pool derived from acellular scaffolds allowed us to hypothesize a model for keratoprosthesis applications derived from livestock combining 3D printing and decellularization.
Synergetic Photocatalytic Peroxymonosulfate Oxidation of Benzotriazole by Cupper Ferrite Spinel: Factors and Mechanism Analysis
Authors: Golshan Masoumeh , Pelalak Rasool , Kakavandi Babak
Published: March 2023

The development of oxidation processes with generating powerful radicals is the most interesting and thought-provoking dimension of peroxymonosulfate (PMS) activation. In this study, a magnetic spinel CuFe2O4 was successfully prepared by a facile, non-toxic, cost-efficient co-precipitation method with the synergetic effect of photocatalytic PMS oxidation against recalcitrant benzotriazole (BTA) pollutant. The high particle dispersion and large surface area (201.898 m2/g) provided a high photocatalytic activity with CuFe2O4. The obtained results from the central composite design (CCD) analysis confirmed the optimum degrading rate of BTA reached 81.4% at the optimum operational condition of CuFe2O4= 0.4 g/L, PMS= 2 mM, BTA= 20 mg/L after 70 min irradiation time. As such, the active species capture experiments revealed the presence of •OH, SO4•‒, O2•‒ and h+ species in CuFe2O4/UV/PMS system where SO4•‒ was dominated for BTA photodegradation. The combination of photocatalysis and PMS activation enhanced the consumption of metal ions in redox cycle reactions, thus preventing metal leaching and maintain the recyclability with reasonable mineralization efficiency which achieved more than 40% total organic carbon removal after four batch experiments. A retardant effect on BTA oxidation was observed with comparing the water’s common anion constituents as HCO3‒ > Cl‒ > NO3‒ > SO2‒. Results from intermediates identification showed that the transformation pathway of BTA developed as the deprotonation, hydrolysis and ring cleavage processes promoting the practical potential of photo-absorbing CuFe2O4 catalyzed PMS which can be a promising method due to convenient magnetic separation form the solution.
Evidence-Based Cosmology and Galactic Rotation Curves
Authors: Šorli Srecko
Published: March 2023

A bijective analysis is confirming, the expansion of universal space has never been directly observed, and this assumption is unproven thus far. The measurement of the gravitational redshift, which was confirmed using the Mossbauer experiment, proves only the gravitational redshift and nothing more because there is no causality between the gravitational redshift and hypothetical expansion. Thus, even if the universal space is assumed to expand, the gravitational redshift cannot be assumed to be proof of the expansion. In addition, the Doppler effect was never observed in an expanding space; thus, the claim that the cosmological redshift is partially caused by the Doppler effect, which is caused by the expansion of space, is an unproven assumption. Furthermore, the discovery of cosmic microwave background (CMB) radiation simply proves that the radiation is emitted by the entire universal space, but does not prove the existence of a recombination period. In evidence-based cosmology, every element in the model has a corresponding element in physical reality that is observed and measured. The evidence-based cosmology model is related to the real universe by a bijective function of set theory. Supermassive black holes in the centre of galaxies are rejuvenating systems of the universe. They rotate their local superfluid space which is the physical origin of galactic rotation curves.
Potent Inhibitors Targeting Metallo-β-lactamases from the B1, B2 and B3 Subgroups: Promising Broad-spectrum Agents to Combat a Major Mechanism of Antibiotic Resistance
Authors: Kurz Julia L , Pedroso Marcelo M , Richard Emmanuelle , McGeary Ross P , Schenk Gerhard
Published: March 2023

Metallo-β-lactamases (MBLs) are a group of Zn(II)-dependent enzymes that pose a major threat to global health. They are linked to an increasing number of multi-drug resistant bacterial pathogens, but no clinically useful inhibitor is yet available. Since β-lactam antibiotics, which are inactivated by MBLs, constitute ~65% of all antibiotics used to treat infections, the search for clinically relevant MBL inhibitors is urgent. Here, derivatives of a 2-amino-1-benzyl-4,5-diphenyl-1H-pyrrole-3-carbonitrile (1a) were synthesised and their inhibitory effects assessed against representatives of each of the three subgroups of MBLs (B1, B2, B3). Several compounds are potent inhibitors of each MBL tested, making them excellent candidates for the development of broad-spectrum drug leads. In particular, compound 5f is highly potent across the MBL subfamilies, with Ki values in the low µM range. Furthermore, this compound also dis-plays synergy in combination with antibiotics such as penicillin G, cefuroxime or meropenem. This molecule thus represents one of the most promising compounds developed yet to combat MBLs.
Real-time power quality measurement audit of government building – A case study in compliance with IEEE 1159
Authors: Ananth DVN , Hannoon Naeem , Mohamed Yunus Mohamed Shahriman Bin , Bin Jamaludin Mohd Hanif , Charavarthy V. V. S. S. S. , Chowdary P. S. R.
Published: March 2023

Power Quality (PQ) measurements and auditing play a vital role for smart grid applications, industrial safety and reliability. The major electrical PQ characteristics and parameters, like Voltage Sags/Swells, Harmonic Distortion, Voltage Unbalance, Voltage Variation & Flicker, and Supply Interruptions, are studied with the aim of maintaining the international or national standards. The electrical characteristics are studied and analyzed for single-phase and poly-phase systems in this IEEE 1159 recommended practice. The significant PQ constraints and parameters, like electromagnetic interference phenomenon deviation from the regular operation due to load equipment or source to load interaction, are described. Further, it is discussed PQ different monitoring devices, roles, and applications. In this paper, power quality monitoring of the equipment using FLUKE instrument and accessories to identify the equipment performance, audit, PQ issues are discussed practically for a two-panel boards switchgear equipment as a case study in Malaysia. Here, trends in voltage and current changes with current imbalances were observed on 1st May 2019 morning 8'o clock and on 7th May 2019 evening at 9'0 clock.
Fundamental aspects in sensor network metrology
Authors: Eichstädt Sascha , Vedurmudi Anupam Prasad , Gruber Maximilian , Hutzschenreuter Daniel
Published: March 2023

Sensor networks have appeared on the 'radar' of metrology only recently and a rigorous treatment and metrological assessment have not yet been established. However, sensor networks as measuring systems underpin many developments in digital transformation, with applications ranging from regulated utility networks to low-cost Internet of Things (IoT). The metrological assessment of sensor networks necessitates a fundamental revision of calibration, uncertainty propagation and performance assessment and new approaches for information and data handling regarding the individual sensors and their interactions in the network to allow a systems metrology approach to be established. This contribution introduces some initial findings from recent research and gives an outlook into future developments.
Multi-platform solution for data acquisition
Authors: Lombardo Luca
Published: March 2023

Analogue data acquisition is a common task which has application in several fields such as scientific research, industry, food production, safety, and environmental monitoring. It can be carried out either using systems designed ad-hoc for a specific application or by using general-purpose Digital Acquisition Boards (DAQ). Several DAQ solutions are nowadays available on the market, however, most of them are extremely expensive and come as commercial closed products, a factor which prevents users to adapt the system to their specific applications and limits the product compatibility to few operating systems or platforms. This paper describes the design and the preliminary metrological characterization of a digital data acquisition solution based on the Teensyduino Development Board. The aim of the project is to create a hardware and software infrastructure suitable to be employed on several operating systems and that can be freely modified by the users when required. Teensyduino board is a well-known development platform which is characterized by high computing performance and USB support. Taking advantage of the Teensyduino features, the proposed system is easy to be calibrated and used, and it provides functions and performance comparable to many commercial DAQs, but at a significantly lower cost.
El rechazo parental en la edad infantil como factor de riesgo en la violencia de pareja en la edad adulta
Authors: González Elices Patricia , Vague Cardona María Elvira
Published: March 2023

El presente estudio tiene como objetivo explorar la relación entre la calidad de los lazos afectivos del padre y de la madre en la infancia con las manifestaciones violentas y variables de ajuste psicológico en la edad adulta de un grupo de varones condenados por violencia contra la mujer. La investigación se realizó en una muestra de 107 hombres penados por violencia de pareja remitidos por los Servicios Sociales Penitenciarios al programa de intervención con maltratadores “Contexto” de la Universidad de Valencia. Tras la aplicación de diferentes instrumentos (Cuestionario de aceptación-rechazo parental, Test de identificación de trastornos por consumo de alcohol, Escala de depresión del Centro de Estudios Epidemiológicos, Escala de Autoestima, Escala de Impulsividad, Inventario de Expresión de Ira Estado/Rasgo e Inventario de Ansiedad Estado/Rasgo) que miden las variables usualmente asociadas a hombres violentos contra su pareja, los resultados mostraron la presencia de dos grupos significativos con base en la aceptación y el rechazo percibido en la infancia. Ante la percepción de rechazo en la infancia resultó significativa la baja autoestima y el elevado consumo de alcohol. Los resultados obtenidos tienen importantes implicaciones a la hora de intervenir con este tipo de población: la incorporación de programas de psicoeducación para padres a fin de prevenir conductas desadaptadas en población adulta.
Prevalencia y correlatos de la violencia en el noviazgo en las adolescentes y jóvenes mexicanas
Authors: Rodríguez Hernández Rogelio , Castillo-Viveros Nemesio , Esquivel-Santoveña Esteban Eugenio
Published: March 2023

El propósito del presente estudio fue conocer la prevalencia y correlatos de la violencia emocional, física y sexual reciente en relaciones de noviazgo en una muestra nacional representativa de mujeres mexicanas solteras de 15 a 24 años (n = 7,140; Medad = 19.3; DT = 2.7). La fuente de información fue la Encuesta Nacional sobre la Dinámica de las Relaciones en los Hogares 2021 (ENDIREH-2021) y se usó un marco ecológico y una perspectiva del conflicto para organizar e interpretar la información. Se encontró que el 19.9%, 2.7% y 2% de las participantes vivieron violencia emocional, física y sexual, respectivamente, en una relación de noviazgo durante el último año. Los factores asociados con los abusos fueron la condición de discapacidad, la violencia vivida en la infancia y por la familia actual de forma reciente, el tiempo con la pareja, el empleo y la participación social. En tanto, las variables que disminuyeron la probabilidad de violencia fueron la escolaridad y el sostener actitudes ante la igualdad de responsabilidades en hombres y mujeres. Estos hallazgos tienen implicaciones para las políticas de atención y prevención de la violencia en el noviazgo.
Analisis Profil Pelajar Pancasila dalam Bahan Ajar IPA Materi Pencemaran Lingkungan Guna Mendukung Education for Sustainable Development
Authors: Maghribi Andre Nurul , Sidik Alfajar
Published: March 2023

Kemendikbud menginjeksikan oreintasi pembangunan berkelanjutan dalam sektor pendidikan harus mengikuti serta melakukan filterisasi terhadap trend global. Peran bahan ajar dalam fenomena ini merupakan salah satu instrumen perangkat pembelajaran yang dapat menunjang proses pembelajaran bagi peserta didik. Berdasarkan amanat kemerdekaan, visi pendidikan nasional, dan orientasi terhadap masa depan bangsa, bahan ajar harus memiliki elemen kunci yang terdapat dalam profil pelajar pancasila sehingga mampu menunjang dalam mewujudkan education for sustainable development. Penelitian ini bertujuan untuk mengetahui instrumen elemen profil pelajar pancasila dalam bahan ajar, keterkaitan elemen kunci profil pelajar pancasila dalam menunjang ESD, dan kesesuaian bahan ajar dengan elemen kunci profil pelajar pancasila sehingga mampu menunjang ESD. Metode yang digunakan adalah kualitatif deskriptif dengan jenis pendekatan studi pustaka. Hasil yang diperoleh berupa adanya elemen kunci profil pelajar pancasila dalam menunjang ESD, indikator bahan ajar yang memuat elemen profil pelajar pancasila, dan kesesuaian bahan ajar. Secara keseluruhan, kedua bahan ajar dapat dikatakan memiliki kesesuaian dengan profil pelajar pancasila dan dapat digunakan untuk menunjang ESD.
Assessment of Small and Medium Scale Enterprises and Employment Generation in Nigeria: an Ardl Approach
Authors: Onyeka Diyoke Kenneth , Awe Emmanuel
Published: March 2023

Small and Medium scale Enterprise (SMEs) has been receiving great attention because of the tremendous impact it plays in society. This is why its development is paramount to any nation. This study assessed the SMEs and employment generation in Nigeria. the study employed time-series data from 1981 to 2021 using Autoregressive Distributed Lag Model as the method of analysis. The finding revealed that there is a positive and significant relationship between Small and Medium-scale Output (SMEO), Gross Domestic Products growth rate (GDPg) and employment generation but an insignificant nexus with poverty reduction (POVR) while also revealed a negative nexus between income generation and employment generation in Nigeria. The study concluded that there is a significant relationship between SMEs and employment generation in Nigeria. It, therefore, concluded that government should create an avenue that all informal SMEs be registered so as to be able to explore them during tax collection.
JEL CODE: D22, E26, and H32.
Trait prioritization in crop breeding programs: a scoping review on tools and methods
Authors: Occelli Martina , Mukerjee Rishabh , Miller Christian , Porciello Jaron , Puerto Sergio , Garner Elisabeth , Funes Mauricio Guerra , Gómez Miguel , Tufan Hale Ann
Published: March 2023

Trait prioritization studies have guided research, development, and investment decisions for public sector crop breeding programs since the 1970s, but the research design, methods and tools underpinning these studies are not well-understood. We used PRISMA-ScR (Preferred Reporting Items for Systematic review and Meta-Analysis Protocols) to evaluate research on trait ranking for major crops over the past forty years. Data extraction and descriptive analysis on 331 papers show uneven attention of crops, lack of systematic sex-disaggregation, and regional bias. The lack of standardized trait data taxonomy across studies, inconsistent research design, and data collection practices make cross comparison of findings impossible. In addition, network mapping of authors and donors shows patterns of concentration and presence of silos within research areas. This study contributes to the next generation of innovation in trait preference to produce more inclusive, demand-driven varietal design that moves beyond trait prioritization focused on productivity and yield.
The Developmental Implications of Nigeria’s Public Spendings: an Ardl Analysis
Authors: Udo Aniefiok Benedict , Akpan Boniface Linus , Nsor Oniko Ndoma
Published: March 2023

Government expenditure is widely recognized as a potent tool for enhancing growth, redistributing income and reducing poverty in an economy. There exists a consensus in the literature that an adequate and effective macroeconomic policy is critical to any successful development process aimed at achieving high employment, sustainable economic growth and price stability. Is the Nigerian government a developmental state? In an attempt to answer this question, this study examined the short and long run impact of public expenditure on economic development in Nigeria from 1980 to 2020. Specifically, it seeks to determine the nature and direction of causality between government spending and economic development by employing the pair wise Granger causality technique and Autoregressive distributed lagged model to evaluate the empirical evidence of the impact of public expenditure on economic development in Nigeria. The granger causality result reveals that there is a bidirectional relationship between government spending and economic development in Nigeria. Also, the analysis showed that there is a long run relationship between public expenditure and economic development. Therefore, this study recommends that to achieve sustainable economic development in Nigeria, Government expenditure should be increased in the health, education and agricultural sectors in the economy.
Can banana peel and sweet potato vines have efficient in diets for growing rabbits?
Authors: Falcone Diuly Bortoluzzi , Klinger Ana Carolina Kohlrausch , Silva Stéfane Sauzem , Adorian Taida Juliana , de Toledo Geni Salete Pinto , Silva Leila Picolli da
Published: March 2023

This study aimed to evaluate the use of banana peel (BP) and sweet potato vines (SPV) as a replacement for maize and alfalfa hay in diets for rabbits. Animal performance, economic analyses, meat composition and color were evaluated for 49 days in a total 50 New Zealand White rabbits weaned at 35 days with average body mass of ±614g. The animals were allotted, in a completely randomized design, into five dietary groups: control diet (0) – without banana peels and sweet potato vines; or experimental diets: 25, 50, 75 and 100 – with 25%, 50%, 75% and 100% of banana peels and sweet potato vines in substitution to maize and alfalfa hay, respectively. Data were compared by ANOVA followed by Tukey test (p<0.05). Results indicate that daily feed intake, mass gain and feed conversion were similar. In addition, the study shows no differences were observed in centesimal compositions and muscle color. The replacement of maize and alfalfa hay by the combination of BP and SPV resulted in reduction in feed costs, reaching 50% in the experimental diet with 100% of substitution the ingredients. It can be concluded, based on the results on animal performance, meat/color composition and economic analyses that BP and SPV may be used as a substitute for maize and alfalfa hay up to 100% in diets for growing rabbits.
Clinical Outcomes in Covid-19 Patients with Pre-Existing Myasthenia Gravis - a Systematic Analysis of Reported Cases
Authors: Daif Ahmad , Gapchup Tejal , Paul Pritikanta
Published: March 2023

INTRODUCTION: Myasthenia gravis (MG) presents an additional challenge in managing COVID-19 as outcomes potentially depend on prior disease control and treatment. Yet the role of pre-existing MG in COVID-19 outcomes has not been established.
METHODS: We searched PubMed, Scopus, and Web of Science databases for reports of MG patients with confirmed COVID-19 until March 2022. We analyzed data on patient demographics, chronicity, and MG control at baseline pre-COVID, treatment history and outcome following COVID infection.
RESULTS: Twenty-nine publications with 119 patients (females n=75, age range 20-93 years, AChR Ab positive n= 65, MuSK Ab positive n= 5, seronegative n=14, unknown n=35) were included. Eighty-three (70%) were hospitalized, more than half with MG exacerbation. There was no significant difference in disease duration or control of MG symptoms at baseline between hospitalized and non-hospitalized. Hospitalization was associated with higher dose of daily prednisone but a comparable proportion of patients were on steroid-sparing agents. Among hospitalized patients, 40% were intubated uncorrelated with MG baseline control. Unfavorable outcome was not always associated with MG exacerbation. Amongst those discharged,75% received intravenous immunoglobulin (IVIG) or Plasmapheresis (PLEX) for MG exacerbation as compared to 67% with a fatal outcome didn’t receive either.
CONCLUSION: Preexisting MG does not appear to be associated with severe COVID-19 outcomes. Higher dose of prednisone prior to COVID-19 infection is associated with increased risk of hospitalization but MG control at baseline did not determine worse outcome. IVIG/PLEX appears safe and potentially can reduce fatality in patients with COVID-19 experiencing MG exacerbation.