bluuebunny/crossref_metadata_2025 huggingface dataset:
SDN-enabled path computation element for autonomous multi-band optical transport networks
Authors: Kosmatos E. , Casellas R. , Nikolaou K. , Nadal L. , Uzunidis D. , Matrakidis C. , Fàbrega J. M. , Svaluto Moreolo M. , Stavdas A.
Published: September 2023

This paper reports on the design, implementation, and validation of an SDN control plane for multi-band optical networks with externalized path computation. The SDN control plane relies on extending current open and standard interfaces to support dynamic service management and decoupled path computation services on multi-band optical networks while accounting for physical layer impairments, which is critical for successful service provisioning. We detail the multi-band optical network resource management and optimization engine for transparent and translucent networks. The system is experimentally validated in a 22-ROADM BT network with emulated hardware showing the performance of the control plane and the considered workflows.
Design and characterization of a varifocal camera system with an extended depth of field and focal range
Authors: Lu Yanzhao , Wang Xuan , Hua Hong
Published: September 2023

This paper presents the design and characterization of a compact and affordable varifocal camera system. With its entrance pupil located in front as the first element for easy access, the camera system offers a working F/# as low as 2, is capable of focusing across a wide depth range from optical infinity to as close as 4 diopters through an electrically tunable lens, and maintains nearly constant angular magnification through the focus range by placing the focusing element at proximity to the entrance pupil. These unique features can find a myriad of applications such as image-based head-mounted display calibration and extended depth of field (EDOF) imaging. The paper further demonstrates a single-shot EDOF imaging function by utilizing its property of nearly constant angular magnification through focus scanning.
Compact angled multimode interference duplexers for multi-gas sensing applications
Authors: Thottoli Ajmal , Vorobev Artem S. , Biagi Gabriele , Iadanza Simone , Giglio Marilena , Magno Giovanni , Grande Marco , O’Faolain Liam
Published: September 2023

A compact, low-loss 2 × 1 angled-multi-mode-interference-based duplexer is proposed as an optical component for integrating several wavelengths with high coupling efficiency. The self-imaging principle in multimode waveguides is exploited to combine two target wavelengths, corresponding to distinctive absorption lines of important trace gases. The device performance has been numerically enhanced by engineering the geometrical parameters, offering trade-offs in coupling efficiency ratios. The proposed designs are used as versatile duplexers for detecting gas combinations such as ammonia-methane, ammonia-ethane, and ammonia-carbon dioxide, enabling customization for specific sensing applications. The duplexers designed are then fabricated and characterized, with a special focus on assessing the impact of the different target wavelengths on coupling efficiency.
Ganzheitliche Wandlungsfähigkeit von Produktionssystemen – der Schlüssel zur Ressourcenwende?
Authors: Bielitz Pia , Jäpel Nicole , Heik David , Reichelt Dirk
Published: September 2023

Wandlungsfähigkeit von Unternehmen ist der Schlüssel, um gegenüber Multikrisen wie in den letzten Jahren bestehen zu können und langfristig handlungsfähig zu bleiben. Gleichzeitig fordert die globale Situation aber auch dringend einen Wandel hin zu einem drastisch reduzierten Ressourcenverbrauch. Im vorliegenden Beitrag wird daher untersucht, wie sich die Wandlungsfähigkeit eines Produktionssystems steigern und gleichzeitig der Ressourceneinsatz im Unternehmen senken lässt. Durch die Zusammenführung der vier grundlegenden Ressourcenschonungsstrategien (repair, reuse, recycle und reduce) mit den fünf etablierten Wandlungsbefähigern (Kompatibilität, Mobilität, Modularität, Skalierbarkeit, Universalität) können die Interdependenzen zwischen diesen evaluiert werden. Die Anwendung dieser auf ein sozio-technisches System fördert dabei außerdem einen gesamtheitlichen und stärker menschzentrierten Ansatz. Anhand des entwickelten Use-Cases „flexible Qualitätssicherung zur Ressourcenschonung“ wird darüber hinaus ein konkretes Anwendungsbeispiel zur parallelen Implementierung eines wandlungsfähigen, menschzentrierten und ressourcenschonenden Prozesses im Unternehmensumfeld erläutert. Damit unterstützt der Beitrag die konsequente Auslegung von Produktionssystemen auf Resilienz, Menschzentrierung und Nachhaltigkeit, welche als die drei wesentlichen Schlüsseltreiber der Industrie 5.0 gelten.
ADAR-mediated regulation of PQM-1 expression in neurons impacts gene expression throughout C. elegans and regulates survival from hypoxia
Authors: Mahapatra Ananya , Dhakal Alfa , Noguchi Aika , Vadlamani Pranathi , Hundley Heather A.
Published: September 2023

The ability to alter gene expression programs in response to changes in environmental conditions is central to the ability of an organism to thrive. For most organisms, the nervous system serves as the master regulator in communicating information about the animal’s surroundings to other tissues. The information relay centers on signaling pathways that cue transcription factors in a given cell type to execute a specific gene expression program, but also provide a means to signal between tissues. The transcription factor PQM-1 is an important mediator of the insulin signaling pathway contributing to longevity and the stress response as well as impacting survival from hypoxia. Herein, we reveal a novel mechanism for regulating PQM-1 expression specifically in neural cells of larval animals. Our studies reveal that the RNA-binding protein (RBP), ADR-1, binds to pqm-1 mRNA in neural cells. This binding is regulated by the presence of a second RBP, ADR-2, which when absent leads to reduced expression of both pqm-1 and downstream PQM-1 activated genes. Interestingly, we find that neural pqm-1 expression is sufficient to impact gene expression throughout the animal and affect survival from hypoxia, phenotypes that we also observe in adr mutant animals. Together, these studies reveal an important posttranscriptional gene regulatory mechanism in Caenorhabditis elegans that allows the nervous system to sense and respond to environmental conditions to promote organismal survival from hypoxia.
Rapid mechanosensitive migration and dispersal of newly divided mesenchymal cells aid their recruitment into dermal condensates
Authors: Riddell Jon , Noureen Shahzeb Raja , Sedda Luigi , Glover James D. , Ho William K. W. , Bain Connor A. , Berbeglia Arianna , Brown Helen , Anderson Calum , Chen Yuhang , Crichton Michael L. , Yates Christian A. , Mort Richard L. , Headon Denis J.
Published: September 2023

Embryonic mesenchymal cells are dispersed within an extracellular matrix but can coalesce to form condensates with key developmental roles. Cells within condensates undergo fate and morphological changes and induce cell fate changes in nearby epithelia to produce structures including hair follicles, feathers, or intestinal villi. Here, by imaging mouse and chicken embryonic skin, we find that mesenchymal cells undergo much of their dispersal in early interphase, in a stereotyped process of displacement driven by 3 hours of rapid and persistent migration followed by a long period of low motility. The cell division plane and the elevated migration speed and persistence of newly born mesenchymal cells are mechanosensitive, aligning with tissue tension, and are reliant on active WNT secretion. This behaviour disperses mesenchymal cells and allows daughters of recent divisions to travel long distances to enter dermal condensates, demonstrating an unanticipated effect of cell cycle subphase on core mesenchymal behaviour.
The transcription factor DUX4 orchestrates translational reprogramming by broadly suppressing translation efficiency and promoting expression of DUX4-induced mRNAs
Authors: Hamm Danielle C. , Paatela Ellen M. , Bennett Sean R. , Wong Chao-Jen , Campbell Amy E. , Wladyka Cynthia L. , Smith Andrew A. , Jagannathan Sujatha , Hsieh Andrew C. , Tapscott Stephen J.
Published: September 2023

Translational control is critical for cell fate transitions during development, lineage specification, and tumorigenesis. Here, we show that the transcription factor double homeobox protein 4 (DUX4), and its previously characterized transcriptional program, broadly regulates translation to change the cellular proteome. DUX4 is a key regulator of zygotic genome activation in human embryos, whereas misexpression of DUX4 causes facioscapulohumeral muscular dystrophy (FSHD) and is associated with MHC-I suppression and immune evasion in cancer. We report that translation initiation and elongation factors are disrupted downstream of DUX4 expression in human myoblasts. Genome-wide translation profiling identified mRNAs susceptible to DUX4-induced translation inhibition, including those encoding antigen presentation factors and muscle lineage proteins, while DUX4-induced mRNAs were robustly translated. Endogenous expression of DUX4 in human FSHD myotubes and cancer cell lines also correlated with reduced protein synthesis and MHC-I presentation. Our findings reveal that DUX4 orchestrates cell state conversion by suppressing the cellular proteome while maintaining translation of DUX4-induced mRNAs to promote an early developmental program.
Piezo1-mediated spontaneous calcium transients in satellite glia impact dorsal root ganglia development
Authors: Brandt Jacob P. , Smith Cody J.
Published: September 2023

Spontaneous Ca2+ transients of neural cells is a hallmark of the developing nervous system. It is widely accepted that chemical signals, like neurotransmitters, contribute to spontaneous Ca2+ transients in the nervous system. Here, we reveal an additional mechanism of spontaneous Ca2+ transients that is mechanosensitive in the peripheral nervous system (PNS) using intravital imaging of growing dorsal root ganglia (DRG) in zebrafish embryos. GCaMP6s imaging shows that developing DRG satellite glia contain distinct spontaneous Ca2+ transients, classified into simultaneous, isolated, and microdomains. Longitudinal analysis over days in development demonstrates that as DRG satellite glia become more synchronized, isolated Ca2+ transients remain constant. Using a chemical screen, we identify that Ca2+ transients in DRG glia are dependent on mechanical properties, which we confirmed using an experimental application of mechanical force. We find that isolated spontaneous Ca2+ transients of the glia during development is altered by manipulation of mechanosensitive protein Piezo1, which is expressed in the developing ganglia. In contrast, simultaneous Ca2+ transients of DRG satellite glia is not Piezo1-mediated, thus demonstrating that distinct mechanisms mediate subtypes of spontaneous Ca2+ transients. Activating Piezo1 eventually impacts the cell abundance of DRG cells and behaviors that are driven by DRG neurons. Together, our results reveal mechanistically distinct subtypes of Ca2+ transients in satellite glia and introduce mechanobiology as a critical component of spontaneous Ca2+ transients in the developing PNS.
Chromatin accessibility, not 5mC methylation covaries with partial dosage compensation in crows
Authors: Catalán Ana , Merondun Justin , Knief Ulrich , Wolf Jochen B. W.
Published: September 2023

The evolution of genetic sex determination is often accompanied by degradation of the sex-limited chromosome. Male heterogametic systems have evolved convergent, epigenetic mechanisms restoring the resulting imbalance in gene dosage between diploid autosomes (AA) and the hemizygous sex chromosome (X). Female heterogametic systems (AAf Zf, AAm ZZm) tend to only show partial dosage compensation (0.5 < Zf:AAf < 1) and dosage balance (0.5<Zf:ZZm<1). The underlying mechanism remains largely elusive. Here, we quantified gene expression for a total of 15 male and female Eurasian crows (Corvus (corone) spp.) raised under common garden conditions. In addition, we characterized aspects of the regulatory epigenetic landscape quantifying chromatin accessibility (ATAC-seq) and 5mC methylation profiles. Partial dosage balance and compensation was due to female upregulation of Z-linked genes which covaried significantly with increased chromatin accessibility of the female Z chromosome. 5mC methylation was tissue and sex chromosome-specific, but unrelated to dosage. With the exception of the pseudo-autosomal region (PAR), female upregulation of gene expression was evenly spread across the Z chromosome without evidence for regional centers of epigenetic regulation, as has, for example, been suggested for the male hypermethylated region (MHM) in chicken. Our results suggest that partial dosage balance and compensation in female heterogametic systems are tightly linked to chromosome-wide, epigenetic control of the female Z chromosome mediated by differential chromatin accessibility.
H4K20me3 is important for Ash1-mediated H3K36me3 and transcriptional silencing in facultative heterochromatin in a fungal pathogen
Authors: Möller Mareike , Ridenour John B. , Wright Devin F. , Martin Faith A. , Freitag Michael
Published: September 2023

Facultative heterochromatin controls development and differentiation in many eukaryotes. In metazoans, plants, and many filamentous fungi, facultative heterochromatin is characterized by transcriptional repression and enrichment with nucleosomes that are trimethylated at histone H3 lysine 27 (H3K27me3). While loss of H3K27me3 results in derepression of transcriptional gene silencing in many species, additional up- and downstream layers of regulation are necessary to mediate control of transcription in chromosome regions enriched with H3K27me3. Here, we investigated the effects of one histone mark on histone H4, namely H4K20me3, in the fungus Zymoseptoria tritici, a globally important pathogen of wheat. Deletion of kmt5, the gene encoding the sole methyltransferase responsible for H4K20 methylation, resulted in global derepression of transcription, especially in regions of facultative heterochromatin. Derepression in the absence of H4K20me3 not only affected known genes but also a large number of novel, previously undetected transcripts generated from regions of facultative heterochromatin on accessory chromosomes. Transcriptional activation in kmt5 deletion strains was accompanied by a complete loss of Ash1-mediated H3K36me3 and chromatin reorganization affecting H3K27me3 and H3K4me2 distribution in regions of facultative heterochromatin. Strains with H4K20L, M or Q mutations in the single histone H4 gene of Z. tritici recapitulated these chromatin changes, suggesting that H4K20me3 is important for Ash1-mediated H3K36me3. The ∆kmt5 mutants we obtained were more sensitive to genotoxic stressors than wild type and both, ∆kmt5 and ∆ash1, showed greatly increased rates of accessory chromosome loss. Taken together, our results provide insights into an unsuspected mechanism involved in the assembly and maintenance of facultative heterochromatin.
Hepatitis B infection status among South Africans attending public health facilities over a five-year period: 2015 to 2019
Authors: Moonsamy Shelina , Pillay Pavitra , Prabdial-Sing Nishi
Published: September 2023

Hepatitis B, a potentially life-threatening viral infection of the liver, remains a global public health concern despite the availability of effective vaccines for over three decades. The aim of our study was to provide national data on active hepatitis B infections in the public health sector of South Africa. We conducted retrospective analyses on national laboratory data over the period 2015 to 2019. We identified 176,530 cases who tested positive for HBsAg (active infection) with a test positivity rate of 9.02%. Of these active infections, 11,355 (6.43%) were found to be chronically infected. We linked 24,839 (14.07%) and 2,461 (21.67%) HBeAg positive results to all active HBV infections and identified chronic infections respectively. Clearance of HBsAg was observed in 5,569 cases, inclusive of clearance in 135 chronic cases. Active HBV infections were significantly higher in men than women over the five years (p < 0.0001). Among individuals who were vaccine-eligible as infants (0 to 19 years old), we observed 4,981 active HBV infections, including 1,131 infections under five years old, majority of which (65.78%) were under one year old. In the under five-year age group, the HBsAg population positivity rate was 0.02% and test positivity rate was 4.83%. Among all women with active HBV infections (78,935), 85.17% were of reproductive age and of these, 13.73% were HBeAg positive. Without a birth dose of the HBV vaccine, lack of routine HBsAg screening at antenatal care, and HBsAg and HBeAg prevalence among women of reproductive age, it is likely that the majority of cases under five years old were vertically infected. Optimal HBV vaccine coverage, inclusive of a birth dose, is key to eliminating horizontal and vertical transmission of HBV. Early identification of HBV chronicity through real time data analysis is fundamental in reducing the risk of liver cirrhosis and hepatocellular carcinoma.
Navigating antiretroviral adherence in boarding secondary schools in Nairobi, Kenya: A qualitative study of adolescents living with HIV, their caregivers and school nurses
Authors: Kipkurui Nicholas , Owidi Emmah , Ayieko James , Owuor Gerald , Mugenya Irene , Agot Kawango , Roxby Alison C.
Published: September 2023

In Kenya, adolescents spend much of their formative years in boarding secondary schools, which presents a challenging environment for antiretroviral (ART) adherence support among adolescents living with HIV (ALHIV). We examined the experiences of ALHIV, caregivers of adolescents, and school nurses regarding navigating ART adherence in boarding secondary schools. Between July and November 2022, we conducted focus group discussions (FGDs) among ALHIV attending boarding schools in Nairobi, Kenya, and caregivers of ALHIV, and in-depth interviews (IDIs) with school nurses. Clinic records were used to identify ALHIV and caregivers, who were invited to participate based on their availability. We categorized boarding schools into national, county, and sub-county levels and selected two schools from each category. We obtained permission from head teachers and invited school nurses to take part in virtual IDIs. The interviews were audio-recorded, transcribed verbatim, and analyzed thematically. We conducted two FGDs with 11 caregivers, two FGDs with 18 adolescents, and 7 IDIs with school nurses. Most of the ALHIV reported having disclosed their HIV status to a school nurse or teacher during admission. School nurse friendliness, being understanding, fair, and confidential were qualities associated with ALHIV willingness to confide in them. Strategies ALHIV used to adhere to medication included: waiting until students were engaged in other activities, waking up early, stepping away from others, and stating their drugs were for different ailments. Caregivers were nervous about school-based adherence counseling, fearing it could lead to inadvertent disclosure of adolescents’ HIV status and stigmatization by fellow students. All school nurses reported lacking appropriate training in HIV adherence counseling for adolescents. ALHIV have devised innovative strategies to navigate pill-taking and enlist quiet support while operating in stigmatized school environments. Establishment of a strong school nurse-adolescent rapport and building nurses’ skills are key to improving school-based support for ALHIV.
Characteristics and outcomes of patients with severe COVID-19 in Indonesia: Lessons from the first wave
Authors: Burhan Erlina , Liu Keibun , Marwali Eva M. , Huth Samuel , Wulung Navy G. H. M. L. , Juzar Dafsah A. , Taufik Muhammad A. , Wijaya Surya O. , Wati Dyah K. , Kusumastuti Neurinda P. , Yuliarto Saptadi , Pratomo Bhirowo Y. , Pradian Erwin , Somasetia Dadang H. , Rusmawatiningtyas Desy , Fatoni Arie Z. , Mandei Jose M. , Lantang Eka Y. , Perdhana Fajar , Semedi Bambang P. , Rayhan Muhammad , Tarigan Tiffany R. S. , White Nicole , Bassi Gianluigi L. , Suen Jacky Y. , Fraser John F.
Published: September 2023

Background

Indonesia’s national response to COVID-19 evolved rapidly throughout 2020. Understanding pandemic response and outcomes is crucial for better mitigation strategies ahead. This study describes the characteristics and outcomes of patients admitted to ICU during the early stages of the pandemic.

Methods

This is a multi-centre prospective observational study including patients from twelve collaborating hospitals in Indonesia. All patients were clinically suspected or laboratory-confirmed COVID-19 cases admitted to ICU between January 2020 and March 2021. The primary outcome was monthly ICU mortality. Descriptive statistics of patient characteristics and treatment were generated as secondary outcomes.

Results

From 559 subjects, the overall mortality was 68% and decreased over the study period, while the mortality of patients that received mechanical ventilation was 92%, consistently high over the study period. Fatal cases showed 2- and 4-day delays from symptoms onset to hospital admissions and ICU admissions, respectively. Evidence-backed approaches which could influence patient outcome, such as extracorporeal membrane oxygenation, prone positioning, renal replacement therapy, and neuromuscular blockade were scarcely administered.

Conclusions

The mortality rate of COVID-19 patients in Indonesia was extremely high during the first major outbreak of disease, particularly in those mechanically ventilated. Delayed admission and unavailability of evidence-based approaches due to high burden on health facility during COVID-19 crisis could be addressed by efficient public health measures and enhancing health infrastructure to improve the future pandemic response.
Development of hamming and hausdorff distance metrics for cubic intuitionistic fuzzy hypersoft set in cement storage quality control: Development and evaluation
Authors: Saeed Muhammad , Saeed Muhammad Haris , Khalid Misbah , Mekawy Ibrahim
Published: September 2023

Quality control is paramount in product manufacturing as it ensures consistent production to meet customer expectations, regulatory requirements and maintain a company’s reputation and profitability. Distance measures within fuzzy sets serve as powerful tools for quality control, allowing for data comparison and identification of potential defects or outliers within a system. This study aims to develop a hybrid concept by combining a Cubic Intuitionistic Fuzzy Set (CIFS) with Soft Set (SS) and extending it to Cubic Intuitionistic Fuzzy Hypersoft Set (CIFHSS). CIFHSS enables handling multiple distinct attributes at the sub-attribute level within a cubic set environment. The concept includes operations like internal, partial internal, external, complement, direct sum, and product. Additionally, six distance metrics are defined within CIFHSS and applied to establish a quality control management system for industrial applications. The versatility of CIFHSS in quality control management stems from its ability to capture and model uncertainty, vagueness, and imprecision in data. This makes it an effective tool for decision-making, risk analysis, and process optimization across a wide range of industrial applications.
Neuronal Ndst1 depletion accelerates prion protein clearance and slows neurodegeneration in prion infection
Authors: Aguilar-Calvo Patricia , Malik Adela , Sandoval Daniel R. , Barback Christopher , Orrù Christina D. , Standke Heidi G. , Thomas Olivia R. , Dwyer Chrissa A. , Pizzo Donald P. , Bapat Jaidev , Soldau Katrin , Ogawa Ryotaro , Riley Mckenzie B. , Nilsson K. Peter R. , Kraus Allison , Caughey Byron , Iliff Jeffrey J. , Vera David R. , Esko Jeffrey D. , Sigurdson Christina J.
Published: September 2023

Select prion diseases are characterized by widespread cerebral plaque-like deposits of amyloid fibrils enriched in heparan sulfate (HS), a abundant extracellular matrix component. HS facilitates fibril formation in vitro, yet how HS impacts fibrillar plaque growth within the brain is unclear. Here we found that prion-bound HS chains are highly sulfated, and that the sulfation is essential for accelerating prion conversion in vitro. Using conditional knockout mice to deplete the HS sulfation enzyme, Ndst1 (N-deacetylase / N-sulfotransferase) from neurons or astrocytes, we investigated how reducing HS sulfation impacts survival and prion aggregate distribution during a prion infection. Neuronal Ndst1-depleted mice survived longer and showed fewer and smaller parenchymal plaques, shorter fibrils, and increased vascular amyloid, consistent with enhanced aggregate transit toward perivascular drainage channels. The prolonged survival was strain-dependent, affecting mice infected with extracellular, plaque-forming, but not membrane bound, prions. Live PET imaging revealed rapid clearance of recombinant prion protein monomers into the CSF of neuronal Ndst1- deficient mice, neuronal, further suggesting that HS sulfate groups hinder transit of extracellular prion protein monomers. Our results directly show how a host cofactor slows the spread of prion protein through the extracellular space and identify an enzyme to target to facilitate aggregate clearance.
Functional and structural analyses reveal that a dual domain sialidase protects bacteria from complement killing through desialylation of complement factors
Authors: Clark Nicholas D. , Pham Christopher , Kurniyati Kurni , Sze Ching Wooen , Coleman Laurynn , Fu Qin , Zhang Sheng , Malkowski Michael G. , Li Chunhao
Published: September 2023

The complement system is the first line of innate immune defense against microbial infections. To survive in humans and cause infections, bacterial pathogens have developed sophisticated mechanisms to subvert the complement-mediated bactericidal activity. There are reports that sialidases, also known as neuraminidases, are implicated in bacterial complement resistance; however, its underlying molecular mechanism remains elusive. Several complement proteins (e.g., C1q, C4, and C5) and regulators (e.g., factor H and C4bp) are modified by various sialoglycans (glycans with terminal sialic acids), which are essential for their functions. This report provides both functional and structural evidence that bacterial sialidases can disarm the complement system via desialylating key complement proteins and regulators. The oral bacterium Porphyromonas gingivalis, a “keystone” pathogen of periodontitis, produces a dual domain sialidase (PG0352). Biochemical analyses reveal that PG0352 can desialylate human serum and complement factors and thus protect bacteria from serum killing. Structural analyses show that PG0352 contains a N-terminal carbohydrate-binding module (CBM) and a C-terminal sialidase domain that exhibits a canonical six-bladed β-propeller sialidase fold with each blade composed of 3–4 antiparallel β-strands. Follow-up functional studies show that PG0352 forms monomers and is active in a broad range of pH. While PG0352 can remove both N-acetylneuraminic acid (Neu5Ac) and N-glycolyl-neuraminic acid (Neu5Gc), it has a higher affinity to Neu5Ac, the most abundant sialic acid in humans. Structural and functional analyses further demonstrate that the CBM binds to carbohydrates and serum glycoproteins. The results shown in this report provide new insights into understanding the role of sialidases in bacterial virulence and open a new avenue to investigate the molecular mechanisms of bacterial complement resistance.
Mire figyeljünk közösen tervezett turisztikai termékek kialakításakor? Esettanulmány Budapestről
Authors: Namaz Lachin , Tvergyák Klaudia Klára
Published: September 2023

Ez a tanulmány a helymárka, a jóllét és az identitás fogalmát vizsgálja a budapesti helymárka kontextusában, továbbá ezen faktoroknak a fenntartható turizmusra gyakorolt közvetlen hatását elemzi. A szerzők a helyi érdekeltek bevonásának fontosságát hangsúlyozzák a valósághű helymárka létrehozásában, és sorra veszik a fővárosi turizmussal kapcsolatos kihívásokat, így a túlturizmust és a kommunikációs hiányosságokat. A szerzők kiemelik Budapest hagyományos fürdőkultúráját, mint a városi turizmus potenciális, közösen létrehozott értékesítési ajánlatát. A helyi fürdőkultúra kultúrális öröksége bemutatásának szándékával közösen létrehozott értékesítési ajánlatot (Co-Created Selling Proposition, CCSP) javasolnak, amelybe bevonnák az üzleti vállalkozásokat, a civil szervezeteket és a turisztikai hatóságokat. A tanulmány arra a következtetésre jut, hogy a turizmus, a jóllét és a kulturális ökoszisztéma szolgáltatásai közti kapcsolatok feltérképezéséhez további kutatásra van szükség.
Design of an After Fall Assistive Device for the Elderly Patients by Finite element methods
Authors: Fakhouri Faisal , Fakhouri Abdulaziz , Ijaz Muhammad Farzik , Alotaibi Majed , Almalki Abdulqader
Published: September 2023

Falling on the ground can cause serious injuries such as bruises, broken bones, head injuries, etc. Annually 684,000 individuals die globally from falling on the ground. There are more than 37 million fall injuries that requires medical care each year. The Center for Disease Control and Prevention (CDC) anticipates seven fall deaths every hour by 2030. In Saudi Arabia, falls are the 6

th major cause of death, and the 7

th major cause of living with a disability. Furthermore, falling on the ground becomes a risk factor with age, obesity, and presence of balance affecting diseases due to fact that individuals have difficulty getting up after a fall, and the majority of them stay on the ground for more than an hour. As a result, the risk of multiple injuries, dehydration, pressure ulcers, rhabdomyolysis, hypothermia, and pneumonia increase. This study aims to design and analyze a device that can assist individuals, especially seniors, at risk to rise up after a fall on the ground with no external help from others. The design of the device was modelled using SolidWorks 2017 (Dassault Systems, Waltham, MA, US). Also, finite element analysis (FEA) was performed to study von Mises stresses and total deformation on the model. FEA results showed that the device could withstand to lift an overweight individual from the ground without reaching the maximum failure stress of a conventional material such as aluminum.
Meta-analysis mathematical model of heavy metals metallothioneins and heat shock proteins human responses cross talk
Authors: Uviase Ogheneovo
Published: September 2023

The functional settings of Metallothioneins (MT) and Heat shock proteins (HSPs) serve to address the cellular microenvironment challenged apoptotic defense under heavy metals (Hm). Traits now revealed of kinetics and cross talk of different timeframes. Literature lacks a mathematical model of their effects, Hm directed as synergism of an overview. Hence here, used forward modeling and inverse methods for evidence outlined steps in the development of a stochastic and/or deterministic approach. Tooled molecular infinity in fluid state targets coefficient unity, stopped-flow analysis of association or dissociation reach equilibrium rate constants, spliceosomal bridging of messenger Ribosomal nucleic acids (mRNAs) and proteins for application of modified Goodwin oscillatory biological differential equations, and experimental Cadmium-resistant property eigenvalue; where advantageous free aging reduction different single HeLa cell line selected. Non-bias sensitivity nonlinear least-squares estimations approximate solutions. Multiple citations zero-, first-, pseudo-first, second-order made computations equivalences confirms known hypothetical practicums of without overexpression of activated kinase Metallothionein transcription factor 1 (MTF1) very a cross talk with Heat shock factor 1 (HSF1) with cells exposed heavy metals doubles partition function unfolded/misfolded protein response (UPR). And then, steady-state elimination of HSF1 correlates Cadmium response element (CRE) affinity of Heme-oxygenase 1 (HO-1) clearance of negatively charged salts of Hm. The model presents expertise basal quantitative design use applications of normal and pathophysiologic states.
O uso da plataforma Pixton para a produção escrita colaborativa em língua inglesa
Authors: Gonçalves Maia Rejane Maria , Figueiredo Francisco José Quaresma de
Published: September 2023

Na busca por alternativas para suavizar os efeitos negativos da pandemia e garantir interação entre discentes, encontramos a plataforma Pixton, que possui diversos recursos para produção de histórias em quadrinhos. Assim, em 2021, alunos de uma instituição pública se dedicaram a escrever colaborativamente histórias em quadrinhos em língua inglesa nessa plataforma. Este estudo de caso qualitativo objetivou investigar as percepções dos aprendizes acerca dessa plataforma e suas possíveis potencialidades para aprendizagem de inglês. Os dados gerados por meio de observação, notas de campo, questionários e tarefas realizadas apontam que essa ferramenta pode estimular a criatividade e a autonomia dos aprendizes e propiciar contextos de aprendizagem inclusivos e colaborativos.
Traditional Pesantren, Parental Involvement, and Santri Well-being: Insights from Pesantren Sunan Pandanaran of Yogyakarta
Authors: Jahidin Asep
Published: September 2023

The importance of student well-being in the context of positive youth development is widely acknowledged, despite little recognitions regarding what it means for santri to live well in the educational setting of traditional pesantren. “santri well-being” encompasses a dual-faceted composition, encompassing affective elements and life satisfaction of the pesantren students. A kiai or caregivers, not only acting as a prominent religious scholar and charismatic leader, but also assumes a pivotal role as a custodial figure within the contextual fabric of traditional pesantren milieu. The focal point of this research revolves around the examination of santri well-being within the context of Pesantren Sunan Pandanaran. With an educational heritage spanning half a century, it maintains a profound affiliation with Nahdlatul Ulama, the largest Islamic organization in contemporary Indonesia. Situated in Yogyakarta, the pesantren has exhibited substantial progress of education strategies over time, adopting modern innovations while upholding its traditional Sunni values and principles. The research methodology involved the purposive selection of eight informants strategically chosen in accordance with the research objectives. This cohort comprises both students and caregivers affiliated with the pesantren. The findings marked Pesantren Sunan Pandanaran’s swift adaptation to modern educational paradigms while preserving its traditional values. A complex network of parental apparatuses exists to provide care, guidance, and support to santri, encapsulating a range of individuals and roles that collectively contribute to overall well-being and development of students. This complexity is further underscored by the collective commitment of pesantren members to uphold the Sunni theology with a demand on righteous and orthodox belief. Through such dynamic caregiving approaches, the pesantren seeks to strike a balance between tradition-innovation, thus fulfilling its mission to nurture santri well-being and satisfaction within a rich Islamic Sunni tradition.
3-A. Tocado, que no hundido
Authors: Díaz Montejo Dori
Published: September 2023

Hablar de educación de la interioridad es hablar de algo necesario y urgente dentro de la educación. Ayudar a los alumnos a descubrir el gran mundo interior que los habita será un gran regalo. La entrada a ese maravilloso universo pasa por trabajar tres áreas fundamentales de la persona: autoconocimiento, autonomía y autorregulación. Estas habilidades suponen la llave que abrirá las puertas a una vida más plena y consciente, ¡un auténtico tesoro!
Protocolo de convivencia en los centros escolares
Authors: Torre Rodríguez Alejandra , Delgado Abad María , Hurtado Velasco Irene
Published: September 2023

Ante la propuesta para realizar una presentación final en la asignatura de Prácticas IV sobre lo que sería para nosotras un protocolo de convivencia “ideal” en un centro educativo, escogimos la opción de presentar la información y las dinámicas de una forma práctica y aplicable a todos los colegios, donde se incluyeran no solo a los docentes, sino también a los alumnos y familias, puesto que todos formamos parte de esta comunidad.

A lo largo del artículo iremos detallando nuestra puesta en práctica con la temática del cine, seleccionando actividades y juegos que hemos ido viendo gracias a nuestras prácticas en los colegios y que hemos tenido la oportunidad de llevar a cabo con anterioridad.
visualización creativa aplicada al campo educativo
Authors: Llorach Masip María José
Published: September 2023

La visualización creativa es muy buena para trabajar todo lo referente a lo emocional y alcanzar metas. A través de ella te enfocas en lo que deseas y no en lo que no quieres, y tiene que ir acompañada de acciones coherentes. Es ideal para niños y adolescentes, para regular sus emociones y llegar a conocerse mejor, ya que es una técnica que ayuda a ir hacia adentro, hacia lo que son y, por tanto, a encontrar las soluciones ellos mismos.
Cinco claves para implementar un programa de habilidades blandas para educadores ignacianos
Authors: Valente Pedro A.
Published: September 2023

Este artículo presenta cinco aspectos que se deben tener en cuenta a la hora de diseñar un plan de formación en habilidades blandas para educadores ignacianos. Las dos primeras claves se refieren a aclaraciones que anteceden a la construcción del plan; las claves tres y cuatro son principios que revelan la particularidad de proponer un programa de habilidades blandas a los educadores ignacianos; la última clave tiene indicaciones prácticas sobre las actividades a incluir en el plan.
Roles of Political Orientation and Social Representations of Social Order on Socio-Representational Construction Towards Universal Basic Income in France
Authors: Dupoirier Samuel , Demarque Christophe , Souville Marc , Forissier Solveig , Lampropoulos Dimitrios
Published: September 2023

As an object which is new, complex and potentially challenging some of the foundations of the Social Order (SO), we sought to study the influence of the Political Orientation (PO) and Social Representations (SR) of the Social Order (Staerklé et al., 2007). Qui a droit à quoi ? Représentations et légitimation de l’ordre social. PUG) on the socio-representational construction of the Universal Basic Income (UBI) and stances towards this measure (attitude and estimated fair amount). Data were collected via Facebook from 264 French general population participants (Mage = 37.8; SD = 12.7; 174 women). Our Structural Equation Model revealed that the PO would be associated with the stances towards the UBI, mediated by the different ways of representing it and the representations of the SO. Results show two differents socio-representational logics in relation to being right-wing and one in relation to being left-wing. This leads to contrasting stances towards the UBI and seems to reflect different desires to maintain or change the SO.
The Transcendental Grounds of Novalis’ Conception of Life as Poetical Work
Authors: Malimpensa Maurizio Maria
Published: September 2023

The aim of the present paper is to show Novalis’ complete belonging to the history of transcendental philosophy by bringing out the connection between his conception of poetry and the issue of transcendental imagination in Kant and Fichte. Given that solving this problem is the main issue around which Novalisian thought is structured, an attempt is made to consider the writing style adopted by the author as necessary to fulfill this task, and not as an arbitrary rhetorical choice. The connection between poetry and philosophy is then explored in the practical role it has to play among human beings, namely, that of revealing the meaning of the whole reality as a manifestation of the absolute. Thus, life itself is properly displayed by the singular existences as absolute creativity, such as that of poetical creations.
Use of waste activated carbon and wood ash mixture as an electrical grounding enhancement material
Authors: Wahba Mahmoud , Abdel-Salam Mazen , Nayel Mohamed , Ziedan Hamdy A.
Published: September 2023

The grounding scheme is one of the main elements for protection system to mitigate the effect of unwanted lightning strikes or operational failures due to faults in generation, transmission and distribution systems. Desert sand soil has a very low electric conductivity, causing weakness in grounding system. To mitigate problems, the soil is supported with a high conductivity agent to adjust the soil conductivity to acceptable levels. A high-cost and non-renewable commercial product can be added to soils to increase their conductivity. This study brings innovation to conventional soil-enhancement materials. A newly developed mixture is proposed, which is composed of waste-activated carbon received from water purification industries and wood ash from agricultural wastes. First, mixture samples with different compositions of available waste materials were prepared. Then, experimental tests were performed and optimized with a combined genetic algorithm (GA) and fuzzy ranking method to estimate the optimal percentage volume value of each material involved in the developed mixture. To validate the effectiveness of the developed mixture, the results were compared with a commercial product available in the market. Also, the obtained results using GA are compared with those obtained by particle swarm optimization (PSO) to appreciate the best GA solutions. The effectiveness of using the developed mixture and the commercial product in reducing the resistance-to-ground of a rod driven in high and low resistivity soils is evaluated. Finally, a sample of the developed mixture was checked to be non-corrosive material for copper grounding rods.
Power quality disturbances classification using autoencoder and radial basis function neural network
Authors: Veeramsetty Venkataramana , Dhanush Aitha , Nagapradyullatha Aluri , Krishna Gundapu Rama , Salkuti Surender Reddy
Published: September 2023

The classification of power quality (PQ) disturbances is a critical task for both utilities and industry. PQ issues cause power system equipment to fail. PQ disruptions also cause significant disruption in the paper and semiconductor industries, with significant financial implications as well as technological difficulties. Deep learning based approaches are used for automatic PQ disturbance classification, which requires huge amounts of data. A PQ disturbance dataset consisting of 12 PQ disturbances is developed using wavelet transform and MATLAB software. In this paper, an autoencoder is used to reduce the dimensionality of power quality disturbances data from higher dimensionality space, which consists of 72 input features, to lower dimensionality space, which consists of 21 input features. Based on data extracted from the autoencoder, a radial basis function neural network is used to identify the type of PQ disturbances. Based on the simulation results, it is observed that radial basis function neural network is able to distinguish the type of PQ disturbance with 92 % accuracy.
Olive Oil World Price Forecasting: A Bayesian VAR Approach
Authors: Messaoudi Haïfa , Abbassi Abdessalem , Khraief Naceur
Published: September 2023

The Tunisian olive oil strategy is based on the development of exports. Extension and modernization measures of Tunisian olivegrove have come into effect these recent years in order to increase the exports and diversify the target markets. Like any other agricultural good, olive oil is subject to world price fluctuations. Forecasting the long-term world price of olive oil is essential both as a decision-making tool and as a strategic factor for the development of the sector. This paper attempts to forecast the long-term olive oil world price using annual time series. The data reveals that the number of observations is too restrictive for a frequentist approach. To overcome the sample shortage, we adopt a Bayesian VAR. We use the hierarchical prior selection to specify the prior parameters. The results show an increase in world price and production. However, the price grows more proportionally than the production. In such a context, the increasing production orientation seems adequate but not sufficient to enhance the Tunisian position on the international olive oil market. For the coming decade, the Tunisian olive oil policy should focus as well on deepening the dynamics of product valorization.
Efficient numerical solution of the Fokker–Planck equation using physics-conforming finite element methods
Authors: Wegener Katharina , Kuzmin Dmitri , Turek Stefan
Published: September 2023

We consider the Fokker–Planck equation (FPE) for the orientation probability density of fiber suspensions. Using the continuous Galerkin method, we express the numerical solution in terms of Lagrange basis functions that are associated with N nodes of a computational mesh for a domain in the 3D physical space and M nodes of a mesh for the surface of a unit sphere representing the configuration space. The NM time-dependent unknowns of our finite element approximations are probabilities corresponding to discrete space locations and orientation angles. The framework of alternating-direction methods enables us to update the numerical solution in parallel by solving N evolution equations on the sphere and M three-dimensional advection equations in each (pseudo-)time step. To ensure positivity preservation as well as the normalization property of the probability density, we perform algebraic flux correction for each equation and synchronize the correction factors corresponding to different orientation angles. The velocity field for the spatial advection step is obtained using a Schur complement method to solve a generalized system of the incompressible Navier–Stokes equations (NSE). Fiber-induced subgrid-scale effects are taken into account using an effective stress tensor that depends on the second- and fourth-order moments of the orientation density function. Numerical studies are performed for individual subproblems and for the coupled FPE-NSE system.
Efficient NOMA system: hybrid heuristic-based network parameter optimization for spectral and energy efficiency with QoS maximization
Authors: Devi R. Prameela , Prabakaran N.
Published: September 2023

Due to its ability to boost the spectral efficiency of wireless communications systems, non-orthogonal multiple access (NOMA) has been deemed promising. NOMA retains the necessary effectiveness to enable 5G communication. The wireless network’s spectral efficiency and energy are reduced due to the limited spectrum and rising demands of users. Because of the mutual cross-tier interference that occurs in heterogeneous networks, NOMA presents brand-new technical difficulties in resource allocation. The use of non-orthogonal resources and spectrum sharing can cause interference that lowers the performance. Therefore, incorporating quality-of-service (QoS) into the design of a new NOMA model with improved bandwidth efficiency and energy efficiency (EE) is absolutely necessary. A deep learning strategy for maximizing the efficiency of spectrum and energy with QoS in NOMA is presented in this paper. In order to increase the efficiency of spectrum and energy with QoS in the NOMA system, an adaptive artificial rabbits Harris Hawks optimization (AARHHO) algorithm is developed to optimize parameters such as the time allocation ratio and beam forming vectors presented in the full-duplex (FD) relay and base station (BS). As a result, the NOMA network efficiency of bandwidth and energy is effectively maximized with QoS using the newly developed AARHHO approach.