bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGEMBANGAN PERANGKAT PEMBELAJARAN DI SENTRA PERSIAPAN MENGGUNAKAN VIDEO YOUTUBE DI PENDIDIKAN ANAK USIA DINI
Authors: Mujiono Dwi Setia
Published: October 2021

Abstrak Pendidikan adalah salah satu elemen terpenting dalam kehidupan, dari pendidikan kita bisa belajar berbagai hal sehingga bisa bermanfaat bagi banyak orang. Oleh karena itu pendidikan dirasa sangaat penting meskipun diterapkan pada anak yang masih berusia sangat muda. Pendidikan Anak Usia Dini (PAUD) merupakan salah satu wadah yang telah disediakan pemerintah bagi balita dan anak kecil untuk menjadi pijakan awalnya dalam dunia pendidikan. Media digunakan guru untuk menyampaikan materi pelajaran kepada siswa sehingga kegiatan pembelajaran dapat berlangsung efektif, efisien, dan menarik. Pemilihan media dilakukan guru berdasarkan isi materi dan metode pelajaran yang digunakan. Video merupakan media yang menarik untuk membelajarkan ilmu pengetahuan alam kepada siswa khususnya pada mata sentra persiapan. Pemilihan media yang dilakukan oleh guru sangatlah penting. Seorang guru dapat menggunakan berbagai alternatif media pembelajaran yang diperkirakan dapat membantu siswa untuk memahami materi pembelajaran. Beberapa media yang dapat digunakan dalam sentra persiapan antara lain media cetak, flanel, papan, media elektronik dan sebagainya. Salah satu media elektronik yang dapat digunakan dalam sentra persiapan adalah perangkat lunak pembelajaran berbasis komputer. penelitian ini termasuk ke dalam penelitian pengembangan. Metode penelitian Recearch And Development (R & D). Metode penelitian ini digunakan untuk menghasilkan produk tertentu dan mengkaji keefektifan produk tersebut. pengembangan perangkat pembelajaran matematika yang berupa Silabus, Rencana Kegiatan Bulanan (RKB), Rencana Kegiatan Harian (RKH), Buku Pembelajaran materi sentra persiapan semester dua pendidikan anak usia dini usia 4-6 tahun. Persentase Siswa yang tuntas 19 dan dipresentasekan 90,4% artinya siswa telah mencapai kompetensi yang telah ditetapkan yaitu memahami masalah yang berkaitan dengan pengenalan angka. Selain itu siswa juga memenuhi kriteri ketuntasan secara klasikal , karena persentase jumlah siswa yang tuntas sebesar 90,4%, sehingga dapat dikatakan bahwa secara keseluruhan siswa telah mencapai kompetensi yang telah ditentukan. dari hasil ini menunjukan bahwa pembelajaran ini bisa dikatakan efektif karena nilai siswa yang tuntas sebesar 90,4%. kata kunci: Pendidikan, PAUD, Sentra, Video, Youtube
Implementasi Pembelajaran Berbasis Masalah untuk Meningkatkan Prestasi Belajar Siswa
Authors: Suriswo  , Maufur
Published: October 2021

Secara umum tujuan penelitian ini adalah mengembangkan model pembelajaran yang dapat meningkatkan prestasi belajar siswa. Menganalisis efektivitas model pembelajaran berbasis masalah (PBM) dapat meningkatkan prestasi belajar siswa yang lebih tinggi dibandingkan dengan hasil belajar sebelumnya yang tidak menggunakan model pembelajaran PBL di SD Negeri Kagok 01 Kecamatan Slawi kabupaten Tegal. Mengetahui bentuk dukungan kepala sekolah, guru-guru lain serta fasilitas dalam penyelenggaraan model pembelajaran PBM. Target Penelitian ini diharapkan menemukan data dan fakta empirik adalah produk yang dikehendaki dari penelitian dan pengembangan ini berupa model pembelajaran PBM Metode penelitian akan dilaksanakan yakni Prasurvey lapangan (model faktual), mengumpulkan informasi/data yang berhubungan dengan: (a) peserta didik; (b) proses belajar mengajar; (c) pengajar atau guru dan (d) sarana, fasilitas serta lingkungan. Draf model, yaitu yang meliputi kegiatan sebagai berikut:(a) perancangan model, terdiri atas merumuskan tujuan/kompetensi, menetapkan materi, dan menyusun rencana pembelajaran, menentukan metode, media, dan teknik penilaian; (b) Penerapan model dengan melakukan pre test. (c). Penerapan model dengan melakukan pos test. (d). Melakukan analisis dengan membandingkan skor pre test dan post test dengan uji t. Dari hasil perhitungan dengan uji t diperoleh, uji t empiris > dari uji t dalam tabel, sehingga disimpulkan bahwa model PBM lebih efektif.
MENGGAGAS REVITALISASI NILAI NILAI PANCASILA DALAM PERAN MASYARAKAT TERHADAP GENERASI MUDA BERBANGSA DAN BERNEGARA
Authors: Kusrina Titi , Mursyidah Dwi Hartati
Published: October 2021

Masalah pemuda merupakan masalah yang abadi dan selalu dialami oleh setiap generasi dalam hubungannya dengan generasi yang lebih tua. Problem itu disebabkan karena akibat dari proses pendewasaan seseorang, penyesuaian dirinya dengan situasi yang baru timbulah harapan setiap pemuda akan mempunyai masa depan yang lebih baik dari pada orang tuanya.

Tujuan penelitian (1) mendeskripsikan menggagas revitalisasi nilai-nilai Pancasila peran masyarakat, (2) mendeskripsikan pemahaman peran masyarakat terhadap generasi muda berbangsa dan bernegara, (3) mendeskripsikan menggagas revitalisasi nilai-nilai Pancasila peran masyarakat terhadap generasi muda berbangsa dan bernegara.

Pancasila merupakan acuan utama bagi pembentukan hukum nasional, kegiatan penyelenggaraan negara, partisifasi warga negara dan pergaulan antar warga negara dalam kehidupan berbangsa dan bernegara. Dengan kata lain, nilai-nilai yang terkandung dalam Pancasila menjiwai seluruh kegiatan berbangsa dan bernegara.

Salah satu bagian dari masyarakat yang sangat diharapkan untuk berpatisipasi dalam memperhatikan lingkungan hidup adalah para generasi muda. Pada era saat ini, sebagai generasi muda yang akan memegang kendali kehidupan dalam bermasyarakat di masa yang akan datang, maka sudah sepantasnya bagi para generasi muda baik laki-laki dan perempuan menjadi generasi yang bijak dalam berbagai aspek kehidupan, begitu juga halnya dalam masalah kelestarian lingkungan, mestinya sebagai generasi penerus bangsa sangat wajib untuk bersifat bijak dalam andil mempertahankan kelestarian lingkungan
Konstruksi Sosial Masyarakat Tentang Kearifan Lokal Di Era Perkembangan Iptek (Studi Fenomenologi Di Kota Tegal)
Authors: Hartati Mursyidah Dwi , Kusrina Tity
Published: October 2021

The social transformation of Tegal society has brought a logical consequence to the society, economically, culturally and politically. Local wisdom provides public protection to survive in the midst of social change. The ability of the Tegal community in dealing with social change is one of the determinants of social wisdom that is there. Some of the things that prove to be the impact of globalization and the advancement of IPTEK in Tegal include; (i) the entry of Hp; (ii) the entry of agricultural technology; (iii) the field of modern education; and (iv) influence in transportation.. Efforts to strengthen the nation's identity and maintain the local wisdom of the people of Tegal have had enough awareness and it was built through a small scope such as family, village, village, town. Villagers usually have more and more resistance to the threat of change. The aspect of the change referred to here is the trasisi of the agrarian society towards the industrial community. Certainly it is a consequence, but researchers have identified some social wisdom that characterized the people of Tegal City
Peningkatan Kemampuan Berpikir Kritis dan Hasil Belajar Melalui Model Pembelajaran Stad dengan Peta Konsep Materi Pencemaran Air di SMP N 3 Slawi
Authors: Indri Puspita Sari  , Antonius Tri Widodo  , Hayati Muriani
Published: October 2021

This study aims to improve cognitive learning outcomes, critical thinking skills, and determine students' responses to the STAD type cooperative model with the concept map media. The study uses a Pre Test Post Test Comparation Group Quation Experiment Design. The sampling technique using Cluster Random Sampling, obtained 2 sample classes namely control class 32 experimental class 32. Data collection techniques using questionnaires, documentation, and tests. The research instrument was tested for validity and reliability. The data analysis technique uses Independent Sample T Test. The results showed a significant difference from the critical thinking skills and learning outcomes, namely the average value of the Post Test critical thinking ability of the experimental class 74.94 higher than the average value of the Post Test control class 65.78 and the average value of the Post Test learning outcomes cognitive experimental class 82.97 higher than the average value of the control class Post Test 66.75. There is an increase in the average N-Gain critical thinking of the experimental class 0.47 the moderate category is greater than the control class 0.2 the low category, while the cognitive learning outcomes of the experimental class 0.65 the medium category is greater than the control class 0.29 the low category. The results of students 'responses differed significantly between the experimental class and the control class, where the STAD learning model with concept maps can improve cognitive learning outcomes and students' critical thinking abilities.
Pengembangan Sumber Daya Manusia Pendidikan Berbasis Penilaian Kinerja
Authors: Faridah  , Hendaryati Neni , Rony Yulianto
Published: October 2021

Pengembangan sumber daya manusia dapat dilakukan melalui program pendidikan. Manajemen kinerja didasarkan kepada kesepakatan tentang sasaran, persyaratan pengetahuan, keahlian, kompetensi, rencana kerja dan pengembangan. Manajemen kinerja memiliki kompetensi untuk menjadi alat bagi pencapaian perubahan    budaya dan perilaku serta merupakan cara untuk memberdayakan karyawan dengan memberikan kendali yang lebih besar atas pekerjaan mereka dan pengernbangan pribadi mereka sendiri. SDM Pendidikan terdiri dari tenaga kependidikan, tenaga pendidik, dan tenaga manajemen yang tugas utamanya merencanakan, mengkoordinasikan, mengevaluasi dan menindaklanjuti kegiatan penyelenggaraan dan pengelolaan program kegiatan kependidikan. Pengembangan SDM adalah salah satu tahapan dari manajemen strategik, termasuk di dalamnya: (1) menambah kecakapan SDM; dan (2) menyediakan manajer yang cakap untuk masa mendatang. Pengembangan meliputi kegiatan yang diarahkan kepada perbaikan dan pertumbuhan kesanggupan sikap, keterampilan, dan pengetahuan dari personel.
INTERSEXES’ AND HUMANS WITH INTEGRATED IMPLANTS RIGHTS PROTECTION ISSUES AND PROSPECTS IN MODERN CONDITIONS
Authors: Myronets O. M.
Published: October 2021

The paper investigates intersexes’ and humans with integrated implants rights protection issues and prospects in modern conditions. Author’s theoretical vision of intersexes and humans with integrated implants understanding and their rights protection was represented. Main issues concerning the mentioned categories of people effective rights protection have been defined. Prospective directions in relation to intersexes’ and humans with integrated implants legal possibili- ties regulation and defence in modern conditions have been outlined.
Static and flow behaviors of supercritical CO2 foam stabilized with betaine surfactant for mobility control application
Authors: Li Weitao , Wang Kai , Zheng Wenkuan
Published: October 2021

Aiming at improving the stability of Supercritical CO2 (SC-CO2) foam in high temperature and salinity reservoirs, a kind of betaine surfactant, Hexadecyl Hydroxypropyl Sulfo Betaine (HHSB), was screened to stabilize SC-CO2 foam. The properties of SC-CO2 foam were improved at elevated temperature and pressure. The effects of surfactant concentration, temperature, pressure and salinity on film drainage rate were measured to explore the stability of SC-CO2 foam. The results showed that an increase of surfactant concentration, pressure and salinity can decrease film drainage rate and enhance the foam stability, which was attributed to the increase of surfactant adsorption at the gas–liquid interface. The performance of SC-CO2 foam formed by HHSB was improved and the tolerant temperature was up to 100 °C. 1-D core flooding experiments indicated that compared with Coinjection of Surfactant and Gas (CSG) method the SC-CO2 foam generated through Surfactant-Alternative-Gas (SAG) method had lower foam strength but better in-depth migration capacity. The high temperature and pressure 3-D sand showed that in Water-Alternative-Gas (WAG) case CO2 broke early through the high permeability layers. In SAG case, SC-CO2 foam can improve the macroscopic sweep efficiency by reducing the CO2 mobility.
Pharmacotherapy of Cytokine Release Syndrome in Severe COVID-19 Patients: A Systematic Review
Authors: Robinson Jared , Banerjee Indrajit , Leclézio Alexandra
Published: October 2021

The coronavirus pandemic which spread from Wuhan China toward the latter part of 2019 has resulted in 216,303,376 confirmed cases and 4,498,451deaths deaths to date. The novelty and lack of a definitive treatment protocol for the virus and the acute respiratory distress syndrome it produces has resulted in patients being placed on artificial ventilation and most often never recovering therefrom. Very little is known about the pathophysiology of the virus and the biological mechanisms in which it disrupts to bring about the now identified wide array of clinical features which are not solely isolated to the respiratory tract. It is now an established fact however, that one of the major pathways implicated and on which often results in the death and or severe complications in COVID-19 patients is the cytokine storm. The use of new drugs to combat such a cytokine storm is thus important considering the current global COVID-19 situation so as to stop the further progression of the disease in patients and decrease both morbidity and mortality by crippling a major mechanism which hastens death in the hosts. It is, therefore, vital that a systematic analysis and review of the various therapeutic agents are undertaken to select the best drug for the treatment of patients with cytokine storm. This research aims to relate the best therapeutic regimens currently available precisely and concisely to physicians so as to ensure the best possible treatment modality is selected for each patient. An extensive review of the literature was done on the following databases: Google scholar, Trip database, EMBASE, PubMed, and PubMed Central. The keywords and the Boolean operators used for searches were “COVID-19” OR “SARS-CoV-2” AND “Therapeutics” OR “drug therapy” AND “Cytokine Release Syndrome.” The discovery and the use of such drugs, namely, Tocilizumab and potent corticosteroids such as dexamethasone and methylprednisolone in the maximum daily doses of 6 mg and 250 mg, respectively, have shown positive outcome to combat cytokine storm in severe COVID-19 patients. The rationale behind the use of these drugs being to suppress the immune system and thus decrease the detrimental cytokine cascade induced in severely ill COVID-19 patients will be instrumental in the treatment and prevention of severe complication. It is vital for the various drugs under trial and implemented in emergency use to be compared and studied so as to best select the drug which can be incorporated into a treatment regimen which is both effective and has diminished adverse effects.
Delayed total hip arthroplasty in patients developing osteoarthritis following acetabular fractures
Authors: Luthra Jatinder S. , Habsi Salim AL
Published: October 2021

Objectives:

The aim of this study is to review the short-term results of total hip arthroplasty (THA) for the management of delayed arthritis after acetabular fractures.

Methods:

This is a retrospective study of operated cases of THA post-acetabular fracture arthritis. Data were collected from computerized hospital records from January 2010 to December 2019. We analyzed post-operative outcomes, which included revision surgery due to any reason, post-operative infection, hip dislocation, sciatic nerve injury, and deep venous thrombosis. In addition, radiographs were evaluated for restoration of the center of rotation (COR), horizontal offset (HO), and vertical offset (VO) by an independent observer.

Results:

A total of 36 cases (30 males and six females) were included in the study. The average age was 55 years. Road traffic accidents were the most common cause of fractures followed by falls from height. The mean time between the fracture and the development of symptoms of arthritis was 48 months. One THA was complicated by post-operative dislocation. Infection was reported in three cases and sciatic nerve injury occurred in one patient. Heterotopic ossification was seen in four cases and thromboembolism developed in one patient. The COR, HO, and VO showed a normal pattern.

Conclusion:

THA after acetabular fractures is a complex surgical procedure with relatively high short-term complications. Restoring the hip biomechanics can help in achieving results that are comparable to primary total hip replacement.
Sistem Kendali Lampu Pada Smart Home Berbasis IOT (Internet of Things)
Authors: Susilo Dody , Sari Churnia , Krisna Galas Widya
Published: October 2021

Penggunaan internet di dunia sudah meluas dan telah banyak menghasilkan  sebuah konsep terbaru yang bernama Internet Of Things konsep ini berdasarkan dengan meluasnya pengguna internet dan keuntungan dari konsep ini bisa mengembangkan mikrokontroler dan sensor oleh karena itu hadir sebuat perancangan sistem kendali Lampu pada Smart Home berbasis Iot (Internet of Things) dengan menggunakan Web Browser yang dapat mengendalikan dengan mudah  peralatan elektronik khusunya pada lampu pada perancangan ini menggunakan Iot yaitu Node MCU yang tersambung dengan relay metode yang dipakai yaitu dengan menekan status pengaturan On/Off pada halaman web dan sistem kendali akan merepon permintaan  halaman web dengan mengubah nya menjadi sebuah reaksi pada sistem kendali On/Off pada lampu .untuk mengakses nya ke web halaman browser sistem kendali lampu dengan mengunakan IP Addres yang terhubung dengan wifi kita sambungan kan  sehingga sistem kendali dapat diguanakan melalui internet.hasil yang didapat dari sistem kendali lampu dengan web browser berhasil dan sesuai dengan keinginan peneliti dan jarak yang dapat di tempuh bisa sampai 50 meter dan jika jarak yang di tempuh terdapat penghalang makan sistem akan mengalamin gangguan atau ketidak stabilan sinyal.
Stabilized numerical method for solving the Oseen type problem with a singularity
Authors: Рукавишников А.В.
Published: October 2021

На основе метода декомпозиции области построен стабилизационный неконформный метод конечных элементов для решения задачи типа Озеена. Для конвективно доминирующих течений с разрывным коэффициентом вязкости определена шкала оптимального выбора стабилизирующего параметра. Результаты численных экспериментов согласуются с теоретической оценкой сходимости.

Purpose. To construct modified approximation approach using the finite element method and to perform numerical analysis for a two dimensional problem on the flow of a viscous inhomogeneous fluids — the Oseen type problem, that is obtained by sampling in time and linearizing the incompressible Navier—Stokes equations. To consider the convection dominated flow case.

Methodology. Based on the domain decomposition method with a smooth curvilinear boundary between subdomains, a stabilization nonconformal finite element method is constructed that satisfies the inf-sup-stability condition. To solve the resulting system of linear algebraic equations, an iterative process is considered that uses the decomposition of the vector in the Krylov subspace with minimal inviscidity, with a block preconditioning of the matrix.

Findings. The results of the numerical experiments demonstrate the robustness of the considered method for different (even small) discontinuous values of viscosity. The differences between finite element and exact solutions for the velocity field and pressure in the norms of the grid spaces decrease as
Numerical simulation of soliton gas within the Korteweg-de Vries type equations
Authors: Диденкулова Екатерина Геннадьевна , Кокорина Анна Витальевна , Слюняев Алексей Викторович
Published: October 2021

Приведены детали численной схемы и способа задания начальных условий для моделирования нерегулярной динамики ансамблей солитонов в рамках уравнений типа Кортевега-де Вриза на примере модифицированного уравнения Кортевега-де Вриза с фокусирующим типом нелинейности. Дано качественное описание эволюции статистических характеристик для ансамблей солитонов одной и разных полярностей. Обсуждаются результаты тестовых экспериментов по столкновению большого числа солитонов.

The details of the numerical scheme and the method of specifying the initial conditions for the simulation of the irregular dynamics of soliton ensembles within the framework of equations of the Korteweg - de Vries type are given using the example of the modified Korteweg - de Vries equation with a focusing type of nonlinearity. The numerical algorithm is based on a pseudo-spectral method with implicit integration over time and uses the Crank-Nicholson scheme for improving the stability property. The aims of the research are to determine the relationship between the spectral composition of the waves (the Fourier spectrum or the spectrum of the associated scattering problem) and their probabilistic properties, to describe transient processes and the equilibrium states. The paper gives a qualitative description of the evolution of statistical characteristics for ensembles of solitons of the same and different polarities, obtained as a result of numerical simulations; the probability distributions for wave amplitudes are also provided. The results of test experiments on the collision of a large number of solitons are discussed: the choice of optimal conditions and the manifestation of numerical artifacts caused by insufficient accuracy of the discretization. The numerical scheme used turned out to be extremely suitable for the class of the problems studied, since it ensures good accuracy in describing collisions of solitons with a short computation time.
Spiral structure of the liquid particles trajectories near free surface of the vortex
Authors: Кистович Анатолий Васильевич , Чаплина Татьяна Олеговна , Степанова Евгения Вячеславовна
Published: October 2021

Экспериментально и аналитически исследованы характеристики вихревого течения со свободной поверхностью, образующегося в результате вращения активаторного диска, расположенного на дне цилиндрического контейнера, заполненного водой. Получены аналитические выражения, показывающие, что траектории жидких частиц вблизи поверхности вихря представляют собой трехмерные спирали, по которым происходит течение от периферии к центу вихря. Показано, что рассчитанные и визуализированные траектории жидких частиц хорошо согласуются между собой и относятся к классу пространственных логарифмических спиралей.

The work is aimed to compare results of analytical and experimental modeling of vortex fluid flow. The compound flow of liquid (water) occurs in a vertical cylindrical container without upper endwall under the action of the disk rotating at the bottom endwall. The two main components of the emerging flow are the toroidal vortex and the vortex with vertical axis. The equations are written in the cylindrical coordinate system dictated by the geometry of the problem. On the basis of the existing analytical expression, which describes the free surface form of the compound vortex in the zero approximation, an approach is developed to describe the trajectories of individual “liquid particles”. The obtained result allows to explore the velocity field structure near the free surface. The obtained expressions indicate that the velocity field near free surface becomes more pronounced in the tangent direction. This result is confirmed in the experimental studies of the compound vortex flow. The analytical forms of liquid particle trajectories near and on the free surface of the compound vortex are obtained. The general particle movement is from the container sidewall along the free surface to its center and further down the spiral-helical line. The images of the visualized particles trajectories both on the free surface (logarithmic spiral) and in the liquid depth are obtained in experiments and testify in favor of the implemented approach to the construction of analytical solution of the liquid particle motion for the vortex flow of the mentioned type. The correspondence of the calculated free surface forms obtained with the help of analytical expressions and those observed in the experiments with different parameters of the vortex flow shows that the developed approach to the problem can be based on a simplified description.
Evaluation of the reliability of building energy performance models for parameter estimation
Authors: Берже   Жулиан , Дутых   Денис
Published: October 2021

The fidelity of a model relies both on its accuracy to predict the physical phenomena and its capability to estimate unknown parameters using observations. This article focuses on this second aspect by analyzing the reliability of two mathematical models proposed in the literature for the simulation of heat losses through building walls. The first one, named DF, is the classical heat diffusion equation combined with the DuFort-Frankel numerical scheme. The second is the so-called RC lumped approach, based on a simple ordinary differential equation to compute the temperature within the wall. The reliability is evaluated following a two stages method. First, samples of observations are generated using a pseudo-spectral numerical model for the heat diffusion equation with known input parameters. The results are then modified by adding a noise to simulate experimental measurements. Then, for each sample of observation, the parameter estimation problem is solved using one of the two mathematical models. The reliability is assessed based on the accuracy of the approach to recover the unknown parameter. Three case studies are considered for the estimation of ( i ) the heat capacity, ( ii ) the thermal conductivity or ( iii ) the heat transfer coefficient at the interface between the wall and the ambient air. For all cases, the DF mathematical model has a very satisfactory reliability to estimate the unknown parameters without any bias. However, the RC model lacks of fidelity and reliability. The error on the estimated parameter can reach 40% for the heat capacity, 80% for the thermal conductivity and 450% for the heat transfer coefficient.
The distinguishing attack on ARX-based lightweight block ciphers
Authors: Сосков А.С. , Рябко Б.Я.
Published: October 2021

Рассмотрено применение атаки различения на ряд легковесных блочных шифров, основанных на ARX-операциях (сложение по модулю, циклический сдвиг и исключающее ИЛИ). Представлены экспериментальные результаты и теоретические оценки устойчивости легковесных шифров Speck, Simon, Simeck, HIGHT, LEA к атаке различения. Вывод, что семейство шифров Simeck не выдерживает эту атаку, сделан на основе прогнозов, полученных путем экстраполяции экспериментальных данных.

The distinguishing attack on modern lightweight ARX-based block ciphers was applied. Distinguishing attack is any form of cryptanalysis on data encrypted by a cipher that allows an attacker distinguishing the encrypted data from random data.

Purpose. Modern symmetric-key ciphers must be designed to be immune to such an attack. The purpose of the work was to estimate the resistance of lightweight ciphers Speck, Simon, Simeck, HIGHT, and LEA to a distinguishing attack.

Methodology. We note that these ciphers are iterated block ciphers. It is means that they transform blocks of plain text into blocks of cipher text by using the cyclically repeated invertible function known as the round function where each iteration is to be referred as a round. We have experimentally found a maximum number of rounds where encrypted data looked like random bit-sequence by using statistical test “Book Stack”. Then we extrapolated the theoretical length required for a successful distinguishing attack on cipher with full-number rounds by a polynomial of a low degree. Note that cryptography attack is considered as successful if the length of the encrypted sequence is less than the length 2K (K — key size).

Originality/value. Our experiments and estimations show, that Simeck with 48bit block size and 96-bit key size is not immune to distinguishing attack. We recommended increasing the number of rounds by 15–20% in order to improve the reliability of the Simeck 48/96.
Construction of the Voronoi diagram with constraints on а plane
Authors: Булгакова Г.Т. , Киреев Т.Ф.
Published: October 2021

Рассмотрен вопрос построения диаграммы Вороного с ограничениями на плоскости, также известный как обобщенная обратная задача Вороного. Эта задача заключается в том, чтобы по заданному набору отрезков на плоскости построить такую диаграмму Вороного, ребра которой будут лежать на этих отрезках. Предложен алгоритм построения диаграммы Вороного с ограничениями с простым доказательством корректности. Описана процедура построения двумерной расчетной сетки на основе такой диаграммы.

Purpose. The problem of construction the Voronoi diagram with constrains on a plane, also known as the generalized inverse Voronoi problem, is considered. The problem is to construct a Voronoi diagram on the plane, which edges lie on a given set of segments. Methodology. Constructing a Voronoi diagram with constraints is based on the formation of a set of circles and the placement of sites of the diagram at the intersections of these circles. The procedure for constructing a diagram is described by a formal language to prove its correctness. Findings. An algorithm for constructing a constrained Voronoi diagram with proof of correctness is proposed. A procedure for constructing a twodimensional computational grid based on such a diagram is described. Value. The proposed algorithm is rather brief and has a simple proof of correctness. The use of such a grid can improve the accuracy of the numerical solution of some problems in fluid mechanics.
Vanishing Bile Duct Syndrome and Hodgkin’s Lymphoma: Case Report and Thorough Review of the Literature
Authors:   Hematology Unit, 1st Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Greece, V Keramidas , C Tastanis ,   Hematology Unit, 1st Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Greece, K Tsirogianni ,   Hematology Unit, 1st Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Greece, P Hytiroglou ,   Department of Pathology, Medical School, Aristotle University of Thessaloniki, Greece, M Papaioannou ,   Hematology Unit, 1st Department of Internal Medicine, AHEPA University Hospital, Medical School, Aristotle University of Thessaloniki, Greece
Published: October 2021

Vanishing Bile Duct Syndrome (VBDS) is a rare, acquired disorder, characterized by progressive destruction and loss of intrahepatic bile ducts. The main clinical manifestations are jaundice and pruritus, caused by intralobular cholestasis. Although the pathogenic mechanism is poorly understood, VBDS has been associated with numerous etiologies such as medications, malignancies, infections and autoimmune diseases. This syndrome can appear as a paraneoplastic phenomenon in patients with Hodgkin’s Lymphoma (HL). Diagnosis is based on clinical evaluation and confirmed via liver biopsy, while treating the underlying cause is the main therapeutic target. If bile duct regeneration does not occur, possible outcomes include cirrhosis, hepatic failure and death, with liver transplantation being the only curative option. In this paper, we describe a case of HL-related VBDS in a 31-year-old female patient, who presented with jaundice, pruritus and cervical lymphadenopathy. The stage of HL was determined as IIA and a liver biopsy was performed, which confirmed the degeneration of bile ducts. The patient was treated with the ABVD regimen and dexamethasone. Follow-up tests were normal and supported the full remission hypothesis. We conducted an analytical literature review and collected the available data from 38 confirmed cases, regarding the epidemiology, viral infections, clinical findings, therapeutic options and outcome.
The Usefulness of Diagnostic Vitrectomy in Neoplastic and Non-Neoplastic Masquerade Syndrome: An Observational Study
Authors:   Ophthalmology Unit, St. Rose Hospital, Kraków, Poland, K Morawski
Published: October 2021

Introduction: Masquerade intraocular inflammation may be considered neoplastic or non- neoplastic masquerades such as primary intraocular lymphoma, leukemia, infectious and inflammatory diseases. These pathologies require a definitive diagnosis, as the treatment modalities are different. The aim of our study was to investigate the safety and usefulness of diagnostic vitrectomy with vitreous humor flow cytometry in eyes with intraocular inflammation of unknown etiology. Methods: A retrospective observational study included 35 eyes of 29 patients with atypical intraocular inflammation unresponsive to corticosteroid therapy. In all cases diagnostic vitrectomy with flow cytometry analysis of the vitreous specimen was performed. Results: Among 35 eyes, the result of diagnostic vitrectomy analysis showed unspecific inflammatory response in 7 (20.0%) eyes, confirmed neoplastic diseases in 5 (14.3%) eyes. All of them it was intraocular lymphoma but one of the eyes with primarily diagnosed lymphoma and one of the eyes with primarily diagnosed unspecific inflammatory response in flow cytometry has been diagnosed finally as a choroidal melanoma after enucleation of the eyeball. Diagnostic vitrectomy excluded neoplastic disease in 7 eyes (20.0%). In 3 eyes (8.6%) bacterial infection, in 4 eyes (11.4%) viral infection. In 2 eyes (5.7%) we excluded bacterial infection, in 7 cases (20.0%) no conclusive results were obtained. The most common adverse event was cataract in patients (12 eyes, 34.3%). Conclusion: Diagnostic vitrectomy with flow cytometry of vitreous humor is helpful in confirming the clinical suspected diagnosis of posterior segment inflammation. Flow cytometry need to be complemented with other diagnostic test including cytopathology, especially in cases suspected of intraocular lymphoma. Flow cytometry of the vitreous humor in choroidal melanoma is not a useful diagnostic tool.
Study on Anti-Inflammatory Activity of Niloticin by Targeting MD-2 Based on Computer-Aided Drug Design and Biolayer Interferometry
Authors:   Liaoning University of Traditional Chinese Medicine, Dalian, Liaoning, China, G Chen , Y Liu ,   Liaoning University of Traditional Chinese Medicine, Dalian, Liaoning, China, M Zhang ,   Liaoning University of Traditional Chinese Medicine, Dalian, Liaoning, China, Y Xu ,   Taizhou Central Hospital (Taizhou University Hospital), Taizhou, Zhejiang, China
Published: October 2021

Niloticin is an active compound from Cortex phellodendri, but its antiinflammatory activity has not yet been explored. The aim of the present study was to assess the drug potential of niloticin and to study the MD-2-targeting mechanism of its anti-inflammatory activity. Niloticin’s drug potential was analyzed using the Traditional Chinese Medicine Systems Pharmacology Database. Molecular docking and biolayer interferometry technology were used to explore the anti-inflammatory mechanism of niloticin by targeting myeloid differentiation protein 2 (MD-2), which mediates a series of Toll-Like Receptor (TLR) 4-dependent inflammatory responses. The cytokines involved in the LPSTLR4/ MD-2-NF-κB pathway were evaluated by ELISA, RT-PCR, and western blot. The results showed that niloticin has drug potential and could bind to MD- 2. Niloticin had no impact on cell viability. Niloticin could significantly decrease the levels of NO, IL-6, TNF-a, and IL-1β (P<0.01) induced by LPS. IL-1β, IL-6, iNOS, TNF-a, and COX-2 mRNA expression levels were decreased by niloticin (all P<0.01). Compared with the control group, TLR4, p65, MyD88, p-p65, and iNOS expression levels induced by LPS were suppressed by niloticin (all P<0.01). In conclusion, niloticin is a potential MD-2 antagonist. It might interact with MD-2 to play an anti-inflammatory role by suppressing the activation of the LPS-TLR4/MD-2-NF-κB signaling pathway.
Changes of Intracerebral Ventricular Width in Children with Leukemia at Diagnosis, During Treatment and in Follow-Up
Authors:   Saarland University Medical Center, Department for Diagnostic and Interventional Neuroradiology, Homburg, Germany, M Mergen , N Graf ,   Saarland University Medical Center, Department of Pediatric Oncology and Hematology, Homburg, Germany, S Scheid ,   Saarland University Medical Center, Department for Diagnostic and Interventional Neuroradiology, Homburg, Germany, H Schubmehl ,   Saarland University Medical Center, Department of Pediatric Oncology and Hematology, Homburg, Germany, M Backens ,   Saarland University Medical Center, Department for Diagnostic and Interventional Neuroradiology, Homburg, Germany, W Reith ,   Saarland University Medical Center, Department for Diagnostic and Interventional Neuroradiology, Homburg, Germany
Published: October 2021

Background: Acute leukemias are the most common cancer in childhood. Due to multimodal treatment, cure rates are excellent today. Therefore, acute toxicities as well as long-term sequelae of the disease and the treatment need to be examined. Neurotoxicity is one of the most important sequelae. Nevertheless, correlation to intracerebral findings in MRI for children with leukemias is scarce. The aim of this study is to examine the changes of intracerebral ventricular width in children treated for leukemia. Material and Methods: In this retrospective analysis, 95 patients (52 male, 43 female) with a primary diagnosis of leukemia (78 ALL, 17 AML) between 2007 and 2017 from a single center were included (median age at diagnosis: 5 years). We analyzed 170 cranial MRI scans (T2, FLAIR axial) and measured ventricular width as the greatest distance between the anterior ventricular horns (GDAH). Results: GDAH enlarges significantly during follow-up in children up to 6 years, those without morphological brain atrophy and in patients with relapse or high-risk leukemia. During the first year after diagnosis male patients, those with ALL, with intermediate risk and with intracerebral pathomorphological changes were most affected. A normalization of GDAH was possible. Conclusion: Treatment of leukemia during childhood can increase ventricular width. This may explain to some degree the known negative impact on neurocognitive functions. Based on these results and those from literature, routine MRIs at diagnosis and during follow-up in children with acute leukemias need to be discussed. Future work has to correlate these findings with neurocognitive function.
Quantum communication complexity of distribution testing
Authors: Belovs Aleksandrs , Castellanos Arturo , Le Gall Francois , Malod Guillaume , A. Sherstov Alexander
Published: October 2021

The classical communication complexity of testing closeness of discrete distributions has recently been studied by Andoni, Malkin and Nosatzki (ICALP'19). In this problem, two players each receive $t$ samples from one distribution over $[n]$, and the goal is to decide whether their two distributions are equal, or are $\epsilon$-far apart in the $l_1$-distance. In the present paper we show that the quantum communication complexity of this problem is $\tilde{O}(n/(t\epsilon^2))$ qubits when the distributions have low $l_2$-norm, which gives a quadratic improvement over the classical communication complexity obtained by Andoni, Malkin and Nosatzki. We also obtain a matching lower bound by using the pattern matrix method. Let us stress that the samples received by each of the parties are classical, and it is only communication between them that is quantum. Our results thus give one setting where quantum protocols overcome classical protocols for a testing problem with purely classical samples.
State-Church Relationships in the Soviet Period (Based on the Materials of Irkutsk and Zabaikalsk Eparchies): Main Tendencies of Modern Regional Historiography
Authors:   East Siberian State Institute of Culture, Tsyrempilova I. S.
Published: October 2021

The article examines the main directions in modern regional historiography of statechurch relationships. The analysis of a wide range of scientific works, which are dedicated to the history of relationships between the Soviet authorities and Orthodox communities in Irkutsk and Zabaikalsk eparchies, allowed identifying the main results in the study of different questions and stated the prospects for further research.
An assessment of admission and outcome trends among neonates admitted in special newborn care unit (SNCU) of Jalgaon, Maharashtra
Authors:   Associate Professor, Department of Community Medicine, Government Medical College, Jalgaon, INDIA., Malkar Vilas
Published: October 2021

Background: Children face the highest risk of dying in their first 28 days of life (neonatal period). Simple interventions have been tested and found to be effective in reducing the neonatal mortality. Facility Based Newborn Care (FBNC) has a significant potential for improving newborn survival. SNCU is a neonatal unit in the vicinity of labor room which is to provide special care (all care except assisted ventilation and major surgery) for sick newborns. Aims and objectives: To study the trend of neonatal admissions and their outcomes over a period of 7 years i.e. from the year (2013) of establishment to current year (2019) at SNCU in a district level hospital in Maharashtra. Materials and method: The present descriptive observational study with longitudinal design was conducted in the Government supported SNCU of District Hospital of Jalgaon District of Maharashtra which included all the neonates admitted in SNCUs from January 2013 to December 2019.The SNCU monthly report which is in a predefined format from Ministry of Health and Family Welfare, Government of India, which includes data on admission information, reasons of admission, course of admission, and mortality reasons (if any) with treatment outcomes was used for data collection. Result: It was seen that during the study period (i.e. from January 2013 to December 2019) total 16489 neonates were admitted to the SNCU. During the first year (2013) total 1182 neonates were admitted which went on increasing in subsequent years as 2494, 2916, 2944, 2525, 2078 and 2350 neonates were admitted in the year 2014,2015, 2016, 2017, 2018 and 2019. Yearwise data shows proportions of males and females were approximately similar with male preponderance in each year. Proportion of outborn neonates went on steadily increasing (26.90% in 2013 to 46.26% in 2019) and that of inborn neonates went on decreasing (73.10% in 2013 to 53.74% in 2019). Yearwise trend shows that more and more (54.65% in 2013 to 68.13% in 2019) LBWs were admitted as compared to NBWs neonates (45.35% in 2013 to 68.13% in 2019). Decreasing trend in the mortality was observed from 2013 to 2019 as neonatal mortality rate went on decreasing. It was recorded 18.75% in 2013, 12.43% in 2014, 11.48% in 2015, 12.59% in 2016, 10.54% in 2017, 4.75% in 2018, and 5.77% in 2019. Conclusion: Over a period of 7 years from 2013 to 2019 neonatal mortality went on decreasing including decrease in LBW. and preterm neonates.
ФОРМУВАННЯ УЯВЛЕННЯ ПРО РОЗПОДІЛ РОЛЕЙ В СІМ'Ї СУЧАСНОЮ МОЛОДДЮ
Authors: Тавровецька Н. І.
Published: October 2021

У статті представлено результати емпіричного дослідження уявлення сучасної молоді про розподіл ролей у сім’ї. Розглянуто аналіз розробленості питання з точки зору гендерного аспекту (психічної статі респондентів) та з урахуванням структури сім’ї респондентів (повні та неповні родини). Наведено результати за опитувальником «Індивідуально- типологічний» (Л.М. Собчик) та опитувальником «Розподіл ролей у сім’ї» (Ю.Є. Альошиної, Л.Я. Гозмана). Констатовано, що для сучасної молоді характерним є відсутність готовності брати на себе відповідальність за долю іншої людини, брати на себе батьківські обов'язки, не сформована установка на створення майбутньої сім'ї. Виявлено вплив гендерних стереотипів щодо розподілу сімейних ролей, статистично доведена відмініть у сприйнятті ролей в родинах між хлопцями та дівчатами, які виховуються у неповних родинах. Встановлено, що у групі респондентів в залежності від типу психічної статі є розбіжності в уявленнях про тип сім'ї, а отже й про розподіл ролей у сім'ї. Дівчата з фемінним типом психічної статі більш схильні до вибору традиційного розподілу ролей у сім'ї, також є й проміжний тип. Фемінні хлопці обирають егалітарні та традиційні сім'ї. Найбільшу кількість таких респондентів склали хлопці з неповних родин. Їх фемінність можна пояснити саме вихованням матері- одиначки. Хлопці з маскуліним типом психічної статті, серед яких є як з повної родини так і ні обирають традиційний типу родини, а от дівчата проявляють амбівалентний вибір: егалітарна та традиційна родина. Молодь з андрогінним типом психічної статі обирають егалітарний тип сімейних стосунків та розподілу ролей. За результатами дослідження доведено, що для образу сучасної сім’ї в уявленнях молоді характерна присутність ознак різних типів сімейних стосунків: традиційні, проміжні та егалітарні сім’ї. У висновках представлені результати, які підтверджені сучасними аналогічними розвідками з даної проблематики. А саме, показано, що відсутній негативний вплив розлучення на відносини батька і дитини, що дитячо-батьківські відносини, у більшості відсотках результатів, залежать від типу психічної статі респондентів, від їх уявлення про образ шлюбного партнера та ті типи сімейних стосунків, які транслює батьківська сім’я.
ОСОБЛИВОСТІ ПРОЯВУ АГРЕСИВНОСТІ У ДІТЕЙ СТАРШОГО ДОШКІЛЬНОГО ВІКУ
Authors: Шевченко Н. Ф. , Булгакова О. Ю. , Ціник Я. Л.
Published: October 2021

В статті представлено результати емпіричного дослідження проявів агресивності у дітей старшого дошкільного віку. Агресивність дитини дошкільного віку охарактеризовано як специфічну форму її дій, завдяки яким дитина демонструє переваги у силі або використовує силу стосовно інших. Визначено домінуючі чинники формування агресивної поведінки дітей дошкільного віку: стилі сімейного виховання та системи сімейних взаємин, чинники мікросередовища (приклади агресивної поведінки, що демонструють дорослі, однолітки та телебачення), фізичні умови оточуючого середовища; вікові та індивідуально-психологічні особливості особистості. Вивчення прояву агресивності у дітей дошкільного віку за шкалою агресивності виявило перевагу вербальної агресії над іншими видами; меншою мірою представлена фізична та непряма агресія. Встановлено, що більшість досліджуваних дошкільників не проявляють агресивність або лише мають тенденції до агресивної поведінки. Результати дослідження за методикою «Неіснуюча тварина» показали, що більша частина вибірки виявляють слабкий рівень агресивності або зовсім не проявляють її. Найменшу частку складають дошкільники з високим та дуже високим рівнем агресивності. Вивчення прояву агресивності за методикою «Тест Руки» засвідчило, що в більшості досліджуваних дошкільників відсутні відкриті агресивні дії. Водночас, у третини вибірки зафіксовано показники вище за норму, що вказує на тенденцію до відкритої агресивної поведінки, небажання пристосовуватися до своєрідного соціального оточення. Аналіз результатів за методикою «Тест тривожності» показав, що значна частка дошкільників мають середній та високий рівні тривожності. Тривожність дитини може виступати особистісним параметром, який сприяє прояву агресивності. На основі теоретичних підходів до проблеми дитячої агресивності в сучасній зарубіжній та вітчизняній психології, вікових особливостей старшого дошкільного віку, а також результатів проведеного емпіричного дослідження, було визначено основні напрями роботи та завдання психокорекційного тренінгу зі зниження та попередження прояву агресивності у дітей старшого дошкільного віку.