bluuebunny/crossref_metadata_2025 huggingface dataset:
State of Necessity in Post Covid-19 Investor-State Arbitration: CMS and LG&E Revisited
Authors: Islam Rumana , Sarker Maksuda
Published: November 2023

Covid-19 has spread its wrath on every aspect of human affairs. Foreign investment is no exception to that. To combat the pandemic, different States have deployed various restrictive measures having a direct bearing on foreign investors. Such actions are likely to result in an influx of investor-State disputes. It can be reasonably assumed that the States will invoke the necessity plea, among other grounds, to negate their responsibilities in such situations. The cases of The CMS Gas Transmission Company v. The Argentine Republic (2005) and LG&E Energy Corporation v. The Argentine Republic (2006) previously sparked debate about the necessity defence’s applicability in investment arbitrations. This article examines the suitability of the defence in investor-State arbitrations in the post- Covid-19 era in light of the CMS and LG&E cases. After careful scrutinization, this article proposes that the unique nature of the crisis borne from the Covid-19 pandemic should be taken into consideration while applying the defence in any pandemic-induced arbitration. It concludes that unless the catalysts associated with the pandemic are taken into account while applying the defence, it will be invariably futile in investor-State arbitrations.

Dhaka University Law Journal, Vol. 33(1), 2023 P.1-22
Correlation Between B line in Lung Ultrasound and Plasma NT-proBNP Level in Patients with Acute Heart Failure
Authors: Zaman Md Hasan , Hosen Md Imam , Moyaj Farhana , Arzu Jahanara , Osmany Dmm F , Ahmed Sheikh Foyez , Hossain Muhammad Mobarack , Hossain Muhammad Kamal , Ahmed Chaudhury Meshkat
Published: November 2023

Background: Acute heart failure (AHF) is a major cause of morbidity and mortality worldwide. Although this is a common cause of dyspnoea, its diagnosis still represents a challenge. Lung ultrasound (LUS) is an emerging point-of-care diagnostic tool.
Objective: The aim of the study was to assess the Correlation between B line in lung ultrasound and plasma NT-proBNP level in patients with acute heart failure & thus to assess the predictive value of B line in patients with suspected acute heart failure.
Materials and Method: Crosssectional observational study conducted in cardiology department of BSMMU from October 2020 to September 2021. Study procedure: 36 patients presenting with of shortness of breath or heart failure diagnosis were enrolled meeting inclusion and exclusion criteria. The number of B-lines by Lung Ultrasound was measured. Correlation between number of B-lines on lung ultrasonography and NT-proBNP level were analyzed. Results: There is a positive correlation between the number of B-lines and the NT-proBNP levels (r=0.55, p< 0.01) in acute heart failure patients.
Conclusion: Patients presenting with acute shortness of breath with raised NTproBNP level, B line detection &quantification by lung ultrasound can be used as a tool for a faster diagnosis and decision-making on lung congestion in acute heart failure.
University Heart Journal 2023; 19(1): 15-19
A PENERAPAN TEKNOLOGI AUGMENTED REALITY BERBASIS ANDROID UNTUK PEMBELAJARAN RANTAI MAKANAN PADA HEWAN
Authors: Putra Ade Dwi , Alexandra Wigo , Puspaningrum Ajeng Savitri
Published: November 2023

Berawal dari masalah bahwa Siswa/I yang mempelajari rantai makanan pada hewan hanya melalui buku membuat mereka kurang memahami sehingga pembelajaran diulang kembali. Maka penelitian ini mencoba membuat solusi masalah tersebut dengan aplikasi Augmented Reality rantai makanan pada hewan yang dapat berjalan pada smartphone dengaan sistem operasi android untuk membantu dalam makanan pada hewan. Aplikasi dibuat menggunakan Unity 3D dan Vuforia SDK yang dijalankan pada perangkat android. Aplikasi ini dibangun menggunakan metode Extreme Programming. Hasil pengujian yang dilakukan menggunakan iso 25010 diperoleh nilai pengujian kualitas aspek fungsional suitability oleh orang dibidang software engineering menunjukan bahwa aplikasi dapat melakukan 100 % fungsinya dengan benar. Hasil pengujian kualitas aspekÂ  usability yang dilakukan pada responden umum diperoleh nilai keseluruhan sebesar 91.44 % yang berarti aspek usability aplikasi ini sangat layak. Dan hasil pengujian kualitas aspek portability pada beberapa device dengan sistem operasi android oreo, pie dan android 10 mendapatkan nilai keseluruhan sebesar 100% yang berarti aspek portability aplikasi dapat dijalankan
MEDIA PEMBELAJARAN KOMPONEN ELEKTRONIKA MENGGUNAKAN TEKNOLOGI AUGMENTED REALITY UNTUK MATAKULIAH ELEKTRONIKA DASAR
Authors: Susanto Try , Prasetyo Agung , Riskiono Sampurna Dadi
Published: November 2023

Dengan berkembangnyaÂ  teknologi saat ini,Â  komputer memilikiÂ  banyak manfaat dalam berbagai bidang umat manusia, yaitu informasi, pendidikan, bisnis, dan komunikasi. Begitu banyak teknologi yang diperlukan untuk mempromosikan aktivitas manusia sehari-hari, seperti aktivitas militer,Â  pemerintahan, perkantoran, hiburan, dan pendidikan. Salah satu teknologi komputer yang saat ini sedang dikembangkan adalah Augmented Reality (AR). AugmentedÂ  RealityÂ Â  menggunakan kamera (real-time)Â  untuk menangkap gambar untuk menampilkanÂ  modelÂ  visual,Â  yangÂ  tentunyaÂ  dapat membantu aktivitasÂ  dalamÂ  sistem pengajaran.Teknologi Augmented Reality (AR) telah dikembangkan di iOS dan Android. KeduaÂ  sistemÂ  operasi mobile iniÂ  tentu menjadi trenÂ  di kalangan pelajar karena sangat mudah digunakan dan bergaya, terutama di platfrom Android.Â  AndroidÂ  adalah sistem operasi berbasis LinuxÂ  yang telah dimodifikasi untuk digunakan pada smartphone dan tablet. Komponen elektronikaÂ  sangat cocok untuk teknologiÂ  ARÂ  karena siswaÂ  kurang memahami bentuk dan fungsi dari komponen tersebut.Â  KarenaÂ  komponen elektronika merupakan suatu alat atau benda, maka merupakan bagian penunjang dariÂ  rangkaian elektronika dan dapat bekerja sesuai dengan peruntukanya. Benda langsung dihubungkan ke papan sirkuit berupa PCB, CCB, Protoboard dan Veroboard dengan cara disolder Pada penelitianÂ  iniÂ  akan dikembangkan sebuahÂ  aplikasiÂ  pembelajaran untukÂ  mengenalkan komponen elektronikaÂ  kepada siswaÂ  yang dapat menampilkan komponen elektronika secara digital menggunakan teknologi Augmented Reality. Aplikasi augmented reality ini menyediakan informasi dalam format multimediaÂ  digital. Aplikasi iniÂ  digunakan untuk memudahkan siswaÂ  dalam mempelajari komponen elektronika melalui model 3D yang disajikan pada smartphone Android,Â  dan untuk bela jar di kelas untuk lebihÂ  memahami deskripsiÂ  komponen elektronika. Anda dapat mengaksesnya nanti. Teknologi augmented realityÂ Â  memilikiÂ  potensi besar sebagai sarana pendidikan dan menurut saya dapat membangkitkan minat dan rasa ingin tahu siswa yang ingin mempelajari lebih jauh tentang komponen elektronika dan fungsinya melalui aplikasi ini.
IMPLEMENTASI METODE ANALITICAL HIRARCHY PROCESS PADA PEMILIHAN KANDIDAT PEJABAT KANTOR WILAYAH KEMENTRIAN HUKUM DAN HAK ASASI MANUSIA LAMPUNG
Authors: Priandika Adhie Thyo , Susanto Erliyan Redy , Supriyadi Ebi
Published: November 2023

Pegawai merupakan sumber daya yang sangat penting untuk menentukan keberhasilan suatu satuan kerja. Pegawai yang berkualitas akan memudahkan satuan kerja dalam mencapai tujuannya, baik dalam hal pengabdian maupun pelayanan. Selama ini, penilaian kinerja pegawai di kantor kementrian hukum dan hak asasi manusia lampung dilakukan oleh bagian kepegawaian yang berkoordinasi dengan kepala instansi. Proses kenaikan jabatan didapat dari surat rekomendasi atau usulan dari pimpinan unit kerja daerah ke pemimpin instansi berwenang di atasnya berdasarkan penilaian pegawai dan kriteria tertentu. Untuk dapat menentukan seorang Pegawai Negeri Sipil bisa naik jabatannya (kriteria) dilihat sesuai dengan PP Nomor 13 Tahun 2002 yaitu berstatus PNS, Serendah-rendahnya memiliki pangkat satu tingkat di bawah jenjang pangkat yang ditentukan, memiliki kualifikasi dan tingkat pendidikan yang ditentukan. Berdasarkan persentase skor yang diperoleh 95,83% dapat disimpulkan menggunakan tabel hasil tersebut berada pada urutan nomor 1 sehingga dapat disimpulkan hasil pengujian usability diperoleh kesimpulan menurut respondenyaitu â€œSangat Setujuâ€ bahwa pengembangan tersebut telah sesuai. Berdasarkan pengujian fungsional suitability yang dihasilkan 97,43% tersebut maka dapat disimpulkan berdasarkan kriteria persentase hasil uji terlah di terima.
APLIKASI PEMBELAJARAN HEWAN REPTIL BERBASIS AUGMENTED REALITY
Authors: Pratama Teja
Published: November 2023

Perkembangan teknologi yang semakin maju, tentunya berpengaruh kedalam berbagai sektor kehidupan manusia. Perkembangan ini turut berperan dalam perkembangan sebuah media pembelajaran. Media pembelajaran menjadi semakin menarik dan semakin ringkas meskipun tidak mengurangi esensi dari materi. Dalam kegiatan belajar mengajar pada tingkatan pendidikan SMA, hewan vebrata termasuk pembelajaran biologi yang salah satu mengajarkan tentang hewan reptil. Oleh karena itu penulis melakukan penelitian di SMAN 1 PADANGCERMIN yang merupakan termasuk mengajarkan mata pelajaran hewan vebrata yang media penyampaian nya masih menggunakan buku. Berdasarkan hasil wawancara dengan ibu Ana Rizki Jana Jayanti, S.Pd. siswa mengalami kendala yang dihadapi dalam proses belajar mata pelajaran biologi khusus nya tentang reptil yaitu terbatasnya fasilitas yang disediakan seperti internet yang kurang mendukung sehingga siswa mengalami kesulitan untuk belajar materi yang berkaitan dengan hewan reptil yaitu tentang pengamatan jenis-jenis reptil dan ciriâ€“ciri nya. Tujuan dari penelitian ini adalah membangun aplikasi pembelajaran hewan reptil menggunakan Augmented Reality yang digunakan memudahkan siswasiswi dalam belajar mengenai hewan vebrata khususnya untuk hewan reptil. Penelitian ini menggunakan metode MDLC.
PERANCANGAN UI/UX PADA APLIKASI PEMESANAN BUKET MENGGUNAKAN METODE USER CENTERED DESIGN (STUDI KASUS: BOUQUET LAMPUNG)
Authors: Pramesti Ardia Gita , Adrian Qadhli Jafar , Fernando Yusra
Published: November 2023

Bouquet Lampung adalah perusahan yang bergerak dibidang jasa pembuatan buket bunga diwilayah Kedaton, Bandar Lampung. Bouquet Lampung menyediakan berbagai macam produk buket seperti buket bunga, buket snack, buket balon, dan buket uang. Bouquet Lampung sendiri memiliki keunggulan yang dimana dapat memesan jenis buket sesuai keinginan pembeli. Dalam pemesanan dan penentuan keinginan jenis buket masih dilakukan melalui whatsapp, admin harus membalas chat dari pembeli untuk memastikan jenis dan produk buket yang dipesan. Namun karena pemesanan buket yang banyak maka dari itu tidak semua pembeli mendapatkan pelayanan dengan baik, banyaknya penentuan keinginan jenis buket dari pembeli membuat penjual kesulitan membalas pesanan satu persatu. Dengan adanya masalah tersebut, maka diperlukan sistem untuk memudahkan proses pemesanan pada Bouquet Lampung, dibutuhkan suatu rancangan aplikasi pemesanan buket. Sistem didukung dengan database yang akan membantu kinerja toko Bouquet Lampung yang lebih cepat, efektif dan efisien. Dari semua perancangan, penelitian melibatkan proses keterlibatan pengguna agar dapat dipahami dan digunakan oleh pengguna. Peneliti menggunakan metode user centered design (UCD) untuk mengatasi permasalahan ketidakmampuan pengguna ketika menggunakan sistem. Metode user centered design (UCD) melibatkan calon pengguna pada tahap awal pengembangan sehingga calon pengguna dapat memberikan masukan mengenai antarmuka sistem pemesanan.
PEMBUATAN GAME EDUKASI PEMBELAJARAN KATA IMBUHAN UNTUK TINGKAT SEKOLAH DASAR (STUDI KASUS SD NEGERI KARANG SARI LAMPUNG UTARA)
Authors: Sutarman Arsy Berlian , Rahmanto Yuri , Puspaningrum Ajeng Savitri
Published: November 2023

Kata imbuhan penting untuk diajarkan pada pembelajaran sekolah karena dapat digunakan oleh siswa saat membuat karya tulis. Namun menurut Ibu Titin Hariyanti selaku wali kelas V SD Negeri Karang Sari, siswa-siswi cenderung sulit menentukan preposisi yang tepat untuk prefiks. Hal ini dapat dipengaruhi oleh kurangnya motivasi belajar siswa yang berakibat pada menurunnya semangat untuk mengikuti proses pembelajaran. Demi menarik motivasi para pelajar, tentu diperlukan beberapa hal yang dapat dijadikan sarana untuk meningkatkan motivasi tersebut salah satunya dengan game yang bergenre edukasi. Penelitian ini memilih model ARCS sebagai pengukuran motivasi belajar karena ARCS bersifat fleksibel. Adapun pengembangan game menggunakan metode Game Development Life Cycle (GDLC). Dalam metode ini ada dari 6 fase yang harus dilewati yaitu: inisialisasi, preproduction, production, testing, Beta dan realease. Game ini bergendre edukasi yang berisi soal-soal yang berkaitan dengan prefiks dan suffiks. Pengujian ARCS dalam penelitian ini terdiri dari dua tahapan yakni sebelum dan setelah penggunaan game edukasi. Sementara pengujian aplikasi game edukasi menggunakan balck box testing. Hasil pengujian menunjukan bahwa motivasi belajar diukur dengan ARCS sebelum menggunakan game adalah 63,84%, motivasi belajar siswa diukur dengan ARCS setelah menggunakan game adalah 87,29%, dan pengujian beta didapat rata-rata perentase kelayakan adalah 92,33%
RANCANG BANGUN APLIKASI GAME EDUKASI KOSAKATA BAKU DALAM BAHASA INDONESIA DI TINGKAT SEKOLAH DASAR (STUDI KASUS SD NEGERI 1 WAY PETAI LAMPUNG BARAT)
Authors: Riyandana Eksa , An Ars Muhammad Ghufroni , Surahman Ade
Published: November 2023

Bahasa baku adalah bahasa yang baik tata tulis, kosakata, maupun tata bahasanya sesuai dengan hasil pembakuan bahasa. Akan tetapi, pada sekolah SDN 1 Way Petai Lampung Barat, masih kurangnya pengetahuan siswa pada materi kosakata baku dan masih menggunakan metode ceramah dan media cetak dalam proses pembelajarannya yang cenderung membuat pembelajaran menjadi monoton, dan siswa juga merasakan bosan saat proses pembelajarannya, oleh karena itu, penulis melakukan penelitian yang bertujuan untuk meningkatkan pengetahuan dan juga meningkatkan nilai siswa pada mata pelajaran bahasa Indonesia khususnya pada materi kosakata baku dengan menggunakan media alat bantu game. Metode yang digunakan dalam penelitian ini adalah Game Development Life Cycle (GDLC) yang memiliki 6 tahapan yaitu inisialisasi/pembuatan konsep, preproduction, production, testing, Beta dan release. Hasil dari penelitian ini berupa sebuah game edukasi yang dapat digunakan sebagai sarana alternatif untuk media pembelajaran pada pelajaran bahasa Indonesia khususnya pada materi kosakata baku di SDN 1 Way Petai Lampung Barat
Optimalisasi Antrian Perawatan Mobil Ford Menggunakan Model Single Channel Single Phase (SCSP) (Studi Kasus Bengkel September Auto Service Bandar Lampung)
Authors: Hadi K Sri Cahyo
Published: November 2023

The September Auto Service (SAS) workshop has a problem, namely the process of queuing for ford car services and maintenance is done manually, so it has an impact on vehicles queuing, it is difficult to see the history of vehicles that have been repaired. In addition, providing information to customers can only be given orally, if there are customers who want to ask about the progress of vehicle repairs, they must be by telephone or come directly sometimes not always responded to because the customer population is so large and in making purchase reports, sales reports and service reports. the vehicle is still manually. Therefore, the SAS workshop should provide innovations to deal with these problems. In its development, the author uses the extreme programming method, as well as for the approach to making the system using an object-based programming paradigm, with a design using UML. a website-based queuing system can help overcome the difficulties of queuing and the vehicle repair/service process because of the application of the Single Channel Single Phase concept which plays a role when inspecting ford car vehicles, and this system can also manage the purchase and sale of ford car spare parts, assisting customers in monitoring the progress of repair work vehicles and provide faster and more accurate purchase, sales and service reports
Media Game Edukasi Berbasis Android Untuk Pembelajaran Benda Hidup dan Tidak Hidup
Authors: Alba Muhammad , Parjito Parjito , Priandika Adhie Thyo
Published: November 2023

Penelitian ini menggunakan metode GDLC (Game Development Life Cycle) yang mempunyai tahapan seperti Initiation, Pre-production, Production, Testing dan Distribution. Dengan berdasarkan hasil observasi dan wawancara penelitian di SD Negeri Jerangkang penulis mengenalkan media pembelajaran berupa game edukasi berbasis android untuk meningkat minat belajar siswa. Dan mengenalkan fitur-fitur dalam game pembelajaran benda hidup dan tidak hidup seperti mode bermain dalam game berupa quis sesuai dengan silabus pembelajaran benda hidup dan tidak hidup, dan terdapat materi pembelajaran dengan menerapkan ciri-ciri pada benda hidup dan tidak hidup beserta contohnya masing-masing. Hasil pengujian pengembangan sistem menggunkan ISO 25010 pada aspek functionality (fungsionalitas) dan portability (portabilitas). Pengujian dilakukan dengan cara pengisian kuisioner dan wawancara dengan jumlah 10 responden yang terdiri dari 7 siswa/i, 2 guru, 1 dosen dan dengan 30 pertanyaan. Pada pengujian functionality (fungsionalitas) menunjukan aplikasi dapat melakukan semua funginya dengan benar sehingga perangkat lunak mendapatkan kriteria hasil uji Sukses dengan presentasi 96,56%. Hasil pengujian kualitas aspek portability pada beberapa versi android (Android 5, Android 7, Android 10 dan Android 11) menunjukan aplikasi dapat di install dan dan dapat berjalan dengan baik sehingga mendapatkan kriteria hasil uji Sukses dengan presentase 100%.
Desain Interaksi Game Belajar Aksara Lampung Bersama Muli Dengan Metode Collision Detection
Authors: Pamungkas Theo Kusuma , Surahman Ade , Abidin Zaenal
Published: November 2023

Lampung script is one of the traditional Indonesian scripts that developed in the south of the island of Sumatra. This script is used to write the Lampung and Malay languages. The Lampung script has a total of 20 main characters. This study aims to find out how to make a game Learning the Lampung script with Muli based on Android with a design that is easy to use and can function as an entertainment medium for learning media and a media for preserving Lampung culture. The method for making this game is collision detection starting from the analysis of design, manufacture and testing. the game model presented is in the form of the noble character as the main character, there is 1 main game, namely matching the Lampung script and 3 learning modes, namely the introduction of the Lampung script, the introduction of children with the Lampung script and the painting of the Lampung script. In making this application using software construct 2. Test results the quality aspect of functionality by 13 respondents showed that the application can perform all its functions correctly so that the software gets the criteria for success test results with a percentage of 97.91%. The results of testing the quality aspect of portability on several versions of Android (Android 5, Android 9, Android 10, Android 11) show that the application can be installed and can run properly so that it gets the criteria for success test results with a percentage of 100%.
Aplikasi Pembelajaran Kuis Interaktif Ilmu Farmasi Berbasis Android
Authors: Bagus Aji , Sulistiyawati Ari , Lathifah Lathifah
Published: November 2023

Based on the case studies that have been conducted, Ma'arif Kotagajah Vocational School majoring in Pharmacy only has 2 professional teaching staff. This causes an educational gap, due to a lack of teaching staff. Therefore, this study aims to produce a design and present an interactive quiz learning application as an additional learning application that can be useful for teachers and students. The method used in this research is the ADDIE development method, which consists of 5 stages namely Analysis, Design, Development, Implementation, and Evaluation. This study also tested the application using the ISO 25010 software testing standard, which has characteristics such as functional suitability, performance efficiency, usability and compatibility. Based on the results of the study, obtaining a feasibility percentage of 77.08% and belonging to the Eligible category. In the usability test, a feasibility presentation of 160% was produced and classified in the Very Eligible category. Compatibility testing on 4 different smartphone devices showed successful results. While testing performance efficiency, it only takes up 11.6 MB of memory.
Rancang Bangun Sistem Informasi Akademik SMK Taman Siswa 1 Tanjung Karang Berbasis Web
Authors: Setiawan Ade , Samsugi Selamet , Alita Debby
Published: November 2023

Perkembangan teknologi informasi saat ini telah memberi manfaat yang besar dalam dunia pendidikan, pembangunan website sekolah dan pembangunan sistem informasi akademik berbasis komputer adalah sebagian pemanfaatan teknologi informasi. Dengan teknologi informasi memungkinkan data-data akademik dapat diolah dengan baik sehingga dalam penyajian informasi akademik yang dibutuhkan dapat diperoleh secara tepat. Tujuan dibuatnya sistem ini adalah untuk mengatasi masalah yang ada di sistem lama yang telah berjalan dengan membuat sistem informasi akademik pada SMK Taman Siswa 1 Tanjung Karang Bandar Lampung. Tujuan dari penelitian ini adalah pembuatan sistem informasi akademik dilakukan menggunakan framework yaitu codeigniter dan menggunakan MySQL sebagai manajemen databasenya yang popular digunakan untuk membangun aplikasi web yang sumber dan pengolahan datanya menggunakan database. Hasil dari penelitian ini adalah sistem informasi akademik yang memuat berbagai informasi meliputi data siswa, data guru, jadwal mata pelajaran, nilai siswa, dan pengujian menggunakan Black box testing dan Pengujian Usability mendapatkan hasil 87% dari hasil pengujian dengan menggunakan 2 responden.
Penerapan Algoritma K-Nearest Neighbor (K-NN) Untuk Analisis Sentimen Publik Terhadap Pembelajaran Daring
Authors: Supriyanto Jepi , Alita Debby , Isnain Auliya Rahman
Published: November 2023

Penelitian ini dilakukan untuk menerapkan algoritma KNN (K-Nearest Neighbor) dalam melakukan sentimen analisis pengguna Twitter tentang isu terkait kebijakan pemerintah tentang Pembelajaran Daring. penelitian menggunakan data Tweet sebanyak 1825 data tweet Bahasa Indonesia data dikumpulkan sejak tanggal 1 Februari 2020 sampai dengan 30 September 2020. Menggunakan library python yaitu Tweepy .pembobotan kata menggunakan TF-IDF, akan dilakukan klasifikasi nilai sentimen ke dalam dua kelas yaitu positif dan negatif. Setelah dilakukan pengujian dengan K sebanyak 20 didapatkan hasil akurasi tertinggi terdapat Pada saat K = 10 dengan nilai akurasi 84,65% dengan presisi mencapai 87%, recall 86% f measure 87% serta error rate mencapai 0,12% dan di dapatkan pula kecenderungan opini publik terhadap Pembelajaran Daring Cenderung Positif.
Penerapan Mapserver Menggunakan Arcgis dan Framework Codeigniter pada Pengembangan Sistem Informasi Georafis
Authors: Wantoro Agus , Yudistira Yudistira , Pasha Donaya , Modeong Merriam , Ratumbuisang Keith Francis
Published: November 2023

Infrastruktur berperan penting sebagai mediator antara sistem ekonomi dan sosial dalam tatanan kehidupan manusia dan lingkungan. PPIP dalam kegiatannya meliputi fasilitas dan mobilisasi masyarakat sehingga mampu melakukan identifikasi permasalahan ketersediaan dan akses ke infrastruktur dasar. Prosedur penyusun perencanaan dan pelaksanakan pembangunan infrastruktur dasar masih terbilang konvensional yaitu dengan cara mendokumentasikan data dalam writer maupun spreadsheet dan data yang sudah diproses di-upload kedalam sistem e-monitoring. Sedangkan daerah pada provinsi Lampung sangat luas sehingga terdapat kesulitan dalam pengawasan infrastuktur setiap wilayah. Sejak pertengahan 1970 dikembangkan sistem untuk menangani informasi yang berefrensi gografis. Lingkup sistem ini mencakup: pengorganisasian data dan informasi; menempatkan informasi pada lokasi geografis tertentu; melakukan komputasi; menyatakan relasi antar objek spasial dengan objek-objek spasial lainnya; dan melakukan analisa spasial. Penerapan mapaserver dengan menggunakan framework codeigniter, postgreeSQL, MYSQL dan ArcGIS pada sistem informasi geografis dapat mengotomasi prosedur pengolahan data, mengelompokan data berdasarkan wilayah pembangunan, dan mempermudah dalam melakukan pencarian data. Pengujian blackbox dapat mengetahui kesalahan terhadap fungsi yang ada, kesalahan interface, kesalahan dalam struktur data atau akses database eksternal, kesalahan kinerja, dan secara fungsional menampilkan hasil yang sesuai dengan harapan. Berdasarkan hasil pengujian dengan total modul uji sebanyak 87 dan total keberhasilan sebesar 100% sehingga penerapan sistem informasi goegrafis layak untuk digunakan
Implementasi Metode Extreme Programming untuk Sistem Pengajuan Tempat PKL Berbasis Web
Authors: Prabandanizwaransa Indita Pyatama , Ahmad Imam , Susanto Erliyan Redi
Published: November 2023

Dalam mengelola pelaksanaan kegiatan PKL/magang, sekolah memerlukan sebuah sistem yang memberikan pelayanan yang baik kepada siswa maupun guru dengan tujuan untuk meningkatkan efisiensi dan kualitas pelayanan yang lebih baik melalui pemanfaatan teknologi informasi. Salah satu upaya sekolah untuk meningkatkan pelayanan tersebut adalah dengan menerapkan sistem pengajuan pelaksanaan kegiatan PKL/magang berbasis web. Manfaat dari sistem pelaksanaan kegiatan PKL/magang berbasis web ini dapat digunakan di sekolah menengah kejuruan khususnya di SMK 2 MEI Bandar Lampung. Penelitian ini bertujuan untuk mengetahui pengaruh pemanfaatan teknologi khususnya pada pelaksanaan kegiatan PKL/magang di sekolah. Penelitian ini menggunakan extreme programming sebagai metode pengembangan sistem perangkat lunak dan menggunakan ISO 25010 untuk pengujiannya. Pengujian dilakukan oleh 6 responden yang terdiri dari dosen, guru dan siswa. Berdasarkan hasil pengujian yang telah dihitung menghasilkan persentase 100% dalam hal fungsional, yang menunjukan bahwa sistem telah Sukses menurut fungsinya, serta dalam hal aspek kemudahan pengguna menghasilkan 96,83% yang menunjukan bahwa sistem telah Sangat Setuju.
Inibitori del cotrasportatore sodio-glucosio di tipo 2 in pazienti sottoposti a trapianto renale
Authors: Tsalouchos Aris
Published: November 2023

Several recent randomized controlled trials (RCTs) have demonstrated the broad clinical application of sodium-glucose cotransporter-2 inhibitors (SGLT2i) in improving kidney and cardiovascular outcomes in patients with native kidney disease. In January 2023, Dapagliflozin became the first SGLT2 inhibitor approved by the Italian Medicines Agency Administration (AIFA) for the treatment of chronic kidney disease (CKD) regardless of diabetic status. However, although these agents have received considerable praise for their cardiovascular and nephroprotective effects among patients with native kidney disease, the safety and efficacy of SGLT2i in the kidney transplant setting are not well-known as safety concerns have led to the exclusion of transplant recipients from all large RCTs. This review will discuss the known mechanisms SGLT2i employ to provide their beneficial effects, the potential benefits and risks of these agents in the context of kidney transplantation, and finally, it will examine the current findings of published literature on SGLT2i use in kidney transplant recipients and propose potential directions for future research.
Efficacy and Safety of Upadacitinib in a Phase II Randomised, Double-Blind, Dose-Ranging Study of Adults with Extensive Non-segmental Vitiligo
Authors: Moir Hannah
Published: November 2023

Vitiligo is an autoimmune skin disorder characterised by acquired distinct white patches of the skin. Currently, limited treatment options are available for vitiligo, and there are no approved systemic therapies.

At the European Academy of Dermatology and Venereology (EADV) Congress in Berlin, Germany, 11th–14th October 2023, Thierry Passeron, Professor and Chair of Dermatology at the Côte d’Azur University, Nice, France, and Head of the Laboratory INSERM U1065 Team 12, Centre Méditerranéen de Médecine Moléculaire (C3M), Côte d’Azur University, Nice, France, presented an oral presentation summarising data from a Phase IIb study of upadacitinib, an oral selective JAK inhibitor, in patients with non-segmental vitiligo (NSV), during the ‘Free Communications II’ session.

Passeron gave an overview of the multicentre, randomised, double-blind, placebo-controlled, dose-ranging study that evaluated the efficacy and safety of upadacitinib in adults with NSV. This article focuses on the clinical efficacy endpoints and the safety profile outcomes presented at the EADV congress. Overall, the study demonstrated the clinical efficacy of upadacitinib at 24 weeks at different doses versus placebo, with improvements in repigmentation over time, up to Week 52, with a favourable safety profile.
Enhanced Structural and Morphological Properties of Doped Cobalt Zinc Ferrite
Authors: El-Salam Asmaa Reda Abd , Rady K. E. , ELFadaly Ezzat A. , Aly Mobarak Hassan
Published: November 2023

In this study, Mn2+ substituted Co0.8−x Mnx Zn0.2 (where x = 0.0, 0.1, 0.2, and 0.3) ferrites are prepared by a coprecipitation method to study the effect of Mn2+ions on the structural and morphological properties. These ferrites are characterized by X-ray powder diffraction (XRD), and Fourier transform infrared. X-ray diffraction patterns of the prepared samples confirm partial substitution of Mn2+ ions that does not change the basic structure of Co0.8 Zn0.2 Fe2O4. It also provides information about the formation of a single-phase spinel structure without any secondary phase. It is concluded that Co0.6 Mn0.2 Zn0.2 Fe2O4 has a spherical shape with an average particle size of 22.51 nm based on TEM, as confirmed by the XRD analysis. FT-IR analysis confirms the formation of vibrational frequency bands associated with the entire spinel structure. The IR spectra of ferrites show two clear and sharp absorption bands in the range of 442.09 and 620.21 cm-1 in the range of 200–1000 cm-1, which confirms the formation of the ferrite composite.
SAT is as hard as solving Homogeneous Diophantine Equation of Degree Two
Authors: Vega Frank
Published: November 2023

In mathematics, a Diophantine equation is a polynomial equation, usually involving two or more unknowns, such that the only solutions of interest are the integer ones. A homogeneous Diophantine equation is a Diophantine equation that is defined by a homogeneous polynomial. Solving a homogeneous Diophantine equation is generally a very difficult problem. However, homogeneous Diophantine equations of degree two are considered easier to solve. We prove that this decision problem is actually in NP-complete under the constraints that all solutions contain only positive integers which are actually residues of modulo 2. In addition, we show its optimization variant is equivalent to solving a problem of quadratic polynomial optimization without the restriction that the variables must be necessarily integers. This means that this optimization problem can be solved over the domains of real numbers with at most quadratic exponent and so, we expect these pre-conditions can turn this problem to be feasibly solved.
Artificial Intelligence in Credit Risk: A Literature Review
Authors: Widagdo Ponco , Pratiwi Rida Adela , Nurlinda Herly , Nurbaeti Nunung , Ismiwati Rika , Kurniawan Faisal Roni , Yusriani Sri
Published: November 2023

This study aimed to address the needs of using artificial intelligence (AI) by investors and industry players toquantify credit risk in a more forward-looking view instead of the traditional non-forward-looking methods.This is a literature review of nine studies on how applications of AI used to provide better forecast power, andwhether the results can be adequately understood by analysts who will need to make decisions based on AIcomputation. We use the keywords "artificial intelligence", "machine learning", and "credit risk" in googlescholar. Full text is obtained from Web of Science if unavailable as open-source documents. The consensus isquite consistent and positive. AI can provide better forecast power, and when used correctly, AI can increasethe acceptance for less privileged people to access credit, which is good for the overall economy. However,several key challenges remain to make this technology affordable, especially on how to reduce the complexityso that more people can learn how to configure, operate, and interpret the AI computation results. This studyis looking for consensus of how AI can help more accurate forecasting of forward-looking credit riskquantification.
Cation exchange chromatography removes FXIa from a 10% intravenous immunoglobulin preparation
Authors: Kang Gil Bu , Huber Alan , Lee Jihye , Kim Min-Jung , Bang Eun , Hong Jeungwoon , Park Seulgi
Published: November 2023

The presence of residual activated coagulation factor XI (FXIa) in some commercial intravenous immunoglobulin (IVIG) products has been identified as the root cause of a small number of thromboembolic events in patients who had received such therapy. Our objectives here were to design and evaluate the manufacturing process of GC5107, a 10% glycine-stabilized IVIG product, for its capacity to remove FXIa. The manufacturing process included a cation exchange chromatography (CEX) step, which employs a resin that binds immunoglobulin G (IgG) with high capacity. Procoagulant activity was assessed using Western blot analysis, enzyme-linked immunosorbent assay, thrombin generation assay, chromogenic FXIa assay, and non-activated partial thromboplastin time (NaPTT) assay. A spiking study in which large quantities of FXIa were added to samples before CEX chromatography was used to examine the robustness of the process to remove FXIa. Western blot and ELISA analyses demonstrated that residual FXIa remained in the intermediate manufacturing products until after CEX chromatography, when it was reduced to undetectable levels. The spiking study demonstrated that CEX chromatography removed >99% of FXI protein and reduced FXI activity to below detection limits, even in samples containing 158-fold greater FXIa levels than that of normal samples. Procoagulant activity in 9 consecutive lots of GC5107 was reduced to below the detection limits of the thrombin generation and chromogenic FXIa assays (<1.56 IU/ml and <0.16 IU/ml, respectively). The NaPTT of >250 s in all 9 lots indicated very low levels of procoagulant activity. We demonstrate that a novel 10% IVIG manufacturing process including CEX chromatography is a robust means of removing FXIa from the final preparation.
Effect of a monitored home-based exercise program combined with a behavior change intervention and a smartphone app on walking distances and quality of life in adults with peripheral arterial disease: the WalkingPad randomized clinical trial
Authors: Silva Ivone , Moreira Célia Sofia , Pedras Susana , Oliveira Rafaela , Veiga Carlos , Moreira Luís , Santarém Daniel , Guedes Daniel , Paredes Hugo
Published: November 2023

Aims

Investigate whether a Home-based Exercise Therapy (HBET) program for patients with Peripheral Arterial Disease (PAD) and Intermittent Claudication (IC) with a behavior change intervention, supported by a smartphone application, is effective in improving walking distances and performance, and quality of life (QoL) over 6 months.

Methods and results

This was a single-center, prospective, two-arm, single-blinded randomized controlled trial including 73 patients with PAD and IC, and three assessment moments: baseline, 3, and 6 months. Participants were randomized to receive a walking exercise prescription, with the support (n = 38) or without the support (n = 35) of the WalkingPad app, between January 2021 and July 2022. Both groups received two face-to-face behavior change sessions and 12 structured and targeted reinforcement phone calls over 6 months. Primary outcomes were between-group differences in pain-free walking distance (PFWD), functional walking distance (FWD), maximal walking distance (MWD), and 6-min walk distance (6 MWD) at 3 and 6 months. Secondary outcomes were QoL and walking impairment. Seventy-three patients (mean age 64 ± 7.2 years, 88% men) participated in this study, 60 of whom completed the three assessment moments. The whole sample significantly improved all primary outcomes in the first 3 months; that is, the average PFWD (151.1 m), FWD (175.2 m), MWD (171.1 m), and 6 MWD (30.8 m) increased from T1 to T2. Only MWD exhibited a significant average increase (35.0 m). Secondary outcomes also increased from baseline to 3 and 6 months. There were no between-group differences, except for MWD, which showed a greater increase at 6 months in the group that used the app, excluding patients with weak walking ability and extreme anxiety symptoms at baseline.

Conclusion

The intervention improved distances and walking skills as well as the physical, mental, and disease-related quality of life among adults with PAD and IC. The group that used the WalkingPad app improved their MWD in 6 months compared to the control group, except for patients with poor walking ability and extreme anxiety symptoms, which suggests the effectiveness of the WalkingPad app for patients with high walking ability and no severe anxiety symptoms. More research is needed to determine the durability of these findings and to explore what app functionality might promote the other outcomes.

Clinical Trial Registration

https://clinicaltrials.gov (NCT04749732).
Effectiveness of a heart disease blended learning program in physiotherapy students: a prospective study
Authors: Marques-Sule Elena , Hernández-Guillén David , Cezón-Serrano Natalia , Arjona-Tinaut Laura , Sillero-Sillero Amalia , Sánchez González Juan Luis , Cobos-Rincón Ana , Juárez-Vela Raúl , Muñoz-Gómez Elena
Published: November 2023

Background

In recent years, novel teaching methodologies have been emerging with the aim of improving student learning. One of them is known as Blended Learning. BL allows educators to integrate elements of traditional face-to-face teaching with tailored online learning modalities, integrating the distinct strengths of both methodologies.

Purpose

To determine the effectiveness of a heart disease blended learning program in undergraduate physiotherapy students.

Methods

124 participants (average age 21.20 ± 4.67 years, 58.87% female) performed an 8-week heart disease blended learning program that included face-to-face classes and online resources. Knowledge was assessed at baseline, at 4, 8, 12 and 20 weeks. Motivation and engagement were assessed at 4 and 8 weeks. Design of the instructions and learning behaviors were measured at 8 weeks. Finally, 108 subjects completed the study

Results

Knowledge significantly increased mid-program (p = 0.02), at the end of the program (p < 0.001), at 12 weeks (p < 0.001) and 20 weeks (p = 0.001). After the intervention, a high intrinsic motivation was shown (5.60 ± 0.80)) over 7), whilst extrinsic motivation scored 4.24 ± 0.97 over 7.Finally, engagement (3.98 ± 0.52) over 5), design of the instructions (4.15 ± 0.62) over 5) and learning behaviors (70.51 ± 36.08) downloads, 28.97 ± 16.09) topics visited, and online questionnaires scored 7.67 ± 1.60) over 10) reported adequate scores.

Conclusion

This program seems to be an appropriate methodology in future physiotherapists, since it improved knowledge and participants exhibited a high motivation and an adequate engagement, design of the program instructions and learning behaviors.
Future treatments for the arteriopathy of ectopic calcification disorders
Authors: Davies Benjamin M. , Rutsch Frank , Vyavahare Naren , Jones Alexander
Published: November 2023

Ectopic calcification disorders, including Generalized Arterial Calcification of Infancy (GACI) and Pseudoxanthoma Elasticum are rare but impactful on individuals, healthcare and society, with significant associated morbidity, mortality and healthcare costs. Available therapies are not curative and focus on reducing extracellular calcification to limit progression of the arteriopathy that is responsible for much of the morbidity and, in the case of GACI, significant early mortality (approximately 50% in infancy). In this article, current and emerging medical approaches are reviewed and critiqued, including dietary manipulation, phosphate binders, bisphosphonates, tissue nonspecific alkaline phosphatase inhibitors, ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) enzyme replacement, allele-specific therapies, gene therapies, and antibody targeted treatment. Available therapies may limit further arterial calcification, but in GACI in particular, significant calcification can be present at birth, contributing to high infant mortality. This highlights the need for new approaches that aim to reverse established calcification, rather than merely slow its progression. Recently, a promising new class of antibody-targeted nanoparticle therapeutics has emerged that can reverse established arterial calcification in animals, restoring arterial elasticity. In one realization, nanoparticles carry established chelators, such as ethylenediaminetetraacetic disodium acid, to sites of arterial damage, concentrating the impact of the chelator where it is needed and limiting off-target effects. Such drugs would complement existing and emerging therapies, such as ENPP1 enzyme replacement, that slow or prevent progression of calcification, by offering an opportunity to “reset” arterial health in ectopic calcification disorders. At present, ectopic calcification disorders are challenging to treat effectively and carry a high burden of morbidity and mortality, particularly in GACI. Recent drug developments offer good reason to be hopeful for a new era of effective therapeutics that may reverse established arterial disease as well as halt its progression.
Direct impact of mindset on reading-based outcomes in upper elementary students with reading difficulties
Authors: Stanley Christopher , Heo Jungyeong , Petscher Yaacov , Al Otaiba Stephanie , Wanzek Jeanne
Published: November 2023

Mindset involves an array of beliefs related to the malleability of certain attributes, including intelligence. One’s growth mindset comprises a variety of cognitive and motivational factors (e.g., learning goals, effort beliefs) and the perception that skill attainment and outcome in any domain are tethered to personal effort. A fixed mindset encompasses goals, beliefs, and perceptions that skill level is not malleable or impacted by effort. Structural equation models tested investigated direct and indirect pathways of mindset and motivational variables (i.e., learning goals, effort beliefs) with reading outcomes (i.e., word reading, fluency, reading comprehension) in a diverse sample of fourth grade students (n = 408) with reading difficulties. Results revealed a direct impact of fixed mindset (−0.21 to −0.36) and effort beliefs (0.18–0.31) on all standardized, reading-based outcomes. There were no significant mediating pathways. Results are juxtaposed to other research in this area, and practical implications are discussed. Growth mindset appears a robust predictor of positive academic outcomes, and it may be beneficial to facilitate growth mindset in classrooms.
Modeling timing and size of juvenile Chinook salmon out-migrants at three Elwha River rotary screw traps: a window into early life history post dam removal
Authors: Liermann Martin C. , Fullerton Aimee H. , Pess George R. , Anderson Joseph H. , Morley Sarah A. , McHenry Michael L. , Taylor mcKenzi N. , Stapleton Justin , Elofson Mel , McCoy Randall E. , Bennett Todd R.
Published: November 2023

Chinook salmon (Oncorhynchus tshawytscha) populations express diverse early life history pathways that increase habitat utilization and demographic resiliency. Extensive anthropogenic alterations to freshwater habitats along with hatchery and harvest impacts have led to marked reductions in early life history diversity across much of the species’ range. The recent removal of two Elwha River dams between 2011 and 2014 restored access to over 90% of the available habitat that had been inaccessible to Chinook salmon since the early 1900s. This provided an opportunity to investigate how renewed access to this habitat might affect life history diversity. As exotherms, egg-to-fry development, juvenile growth, and movement are influenced by water temperatures. We used spatially and temporally explicit Elwha River water temperature and Chinook salmon spawning location data, in conjunction with spawn timing, emergence, growth, and movement models, to predict observed timing and sizes of juvenile Chinook salmon captured in three rotary screw traps in the mainstem and two tributaries during four trap years. This effort allowed us to test hypotheses regarding Elwha River Chinook salmon early life history, identify potential problems with the data, and predict how emergence and growth would change with increased spawning in the upper watershed. Predicted Chinook salmon emergence timing and predicted dates that juveniles reached 65 mm differed by as much as 2 months for different river locations due to large differences in thermal regimes longitudinally in the mainstem and between tributaries. For 10 out of the 12 trap–year combinations, the model was able to replicate important characteristics of the out-migrant timing and length data collected at the three traps. However, in most cases, there were many plausible parameter combinations that performed well, and in some cases, the model predictions and observations differed. Potential problems with the data and model assumptions were identified as partial explanations for differences and provide avenues for future work. We show that juvenile out-migrant data combined with mechanistic models can improve our understanding of how differences in temperature, spawning extent, and spawn timing affect the emergence, growth, and movement of juvenile fish across diverse riverine habitats.
Trans-ancestry polygenic models for the prediction of LDL blood levels: an analysis of the United Kingdom Biobank and Taiwan Biobank
Authors: Hassanin Emadeldin , Lee Ko-Han , Hsieh Tzung-Chien , Aldisi Rana , Lee Yi-Lun , Bobbili Dheeraj , Krawitz Peter , May Patrick , Chen Chien-Yu , Maj Carlo
Published: November 2023

Polygenic risk score (PRS) predictions often show bias toward the population of available genome-wide association studies (GWASs), which is typically of European ancestry. This study aimed to assess the performance differences of ancestry-specific PRS and test the implementation of multi-ancestry PRS to enhance the generalizability of low-density lipoprotein (LDL) cholesterol predictions in the East Asian (EAS) population. In this study, we computed ancestry-specific and multi-ancestry PRSs for LDL using data obtained from the Global Lipid Genetics Consortium, while accounting for population-specific linkage disequilibrium patterns using the PRS-CSx method in the United Kingdom Biobank dataset (UKB, n = 423,596) and Taiwan Biobank dataset (TWB, n = 68,978). Population-specific PRSs were able to predict LDL levels better within the target population, whereas multi-ancestry PRSs were more generalizable. In the TWB dataset, covariate-adjusted R2 values were 9.3% for ancestry-specific PRS, 6.7% for multi-ancestry PRS, and 4.5% for European-specific PRS. Similar trends (8.6%, 7.8%, and 6.2%) were observed in the smaller EAS population of the UKB (n = 1,480). Consistent with R2 values, PRS stratification in EAS regions (TWB) effectively captured a heterogenous variability in LDL blood cholesterol levels across PRS strata. The mean difference in LDL levels between the lowest and highest EAS-specific PRS (EAS_PRS) deciles was 0.82, compared to 0.59 for European-specific PRS (EUR_PRS) and 0.76 for multi-ancestry PRS. Notably, the mean LDL values in the top decile of multi-ancestry PRS were comparable to those of EAS_PRS (3.543 vs. 3.541, p = 0.86). Our analysis of the PRS prediction model for LDL cholesterol further supports the issue of PRS generalizability across populations. Our targeted analysis of the EAS population revealed that integrating non-European genotyping data with a powerful European-based GWAS can enhance the generalizability of LDL PRS.