bluuebunny/crossref_metadata_2025 huggingface dataset:
Sustainable development of the economy in the conditions of the energy crisis
Authors: Shtunder I , Kushnir S , Perevozova I , Kalinina S , Savchenko E , Nitsenko V
Published: August 2022

Purpose. To establish the factors of the impact of the energy crisis on the formation of a sustainable economy. To propose a method for forecasting the balance of energy production and consumption. To establish the level of correlation between sustainable development indicators and energy indicators. Methodology. Cognition methods were used to perform the work: analysis and synthesis to choose the topic and purpose of the study; content analysis for literature review; critical analysis to identify unsolved aspects of the problem and national characteristics of the crisis; the ascent from the abstract to the concrete to prove the relationship between the energy crisis and achievement of the sustainable development goals (SDG); system analysis to substantiate the need for energy balance and import substitution of energy resources; induction and deduction for the selection of SDGs, which are affected by the energy crisis and energy balance forecasting models, establishing the level of correlation with SDG indicators; idealization and formalization to identify factors inhibiting the formation of a sustainable economy. Findings. It is established that in addition to the global factors of the energy crisis, national economies have their own factors influencing the pace of achieving the SDG. The main reasons for the gap between energy production and consumption and trends in import substitution in the energy sector are indicated. The presence of direct and reverse effects of energy development and sustainable development is proved. It is established that the solution to the problem of sustainable economic development is to systematically ensure the dynamic balance of production and consumption of energy, and import substitution of energy resources. Originality. The reasons for reducing the level of relevance of forecasting and energy plan required to achieve the SDG are identified. There is a significant level of correlation between the Mtoe indicator and groups of SDG indicators and the fact that indicator of relative fluctuations as for average Mtoe is an integral indicator of the SDG achievement. Practical value. The MCDA method and a quantitative approach to its implementation are proposed to forecast energy consumption and to model sustainable development scenarios.
ALOKASI DANA DESA SEBAGAI UPAYA PENINGKATAN PEMBANGUNAN DESA TAMAN KUNCARAN KECAMATAN TIRTOYUDO KABUPATEN MALANG
Authors: Adiwidjaja Ignatius , Suprojo Agung
Published: August 2022

Acceleration in the implementation of development certainly requires a budget whose funding sources are always ready to work. This will directly affect social welfare, economy , as well as education for the people of Taman Kuncaran Village, Tirtoyudo District, Malang Regency. Focus research is Role Government Village in Village Fund Allocation as effort enhancement development. Results research shows that with the realization of the Village Fund Allocation (ADD); the structure of social, economic, and educational development can touch all levels of society, social and economic welfare, for the people of Taman Kuncaran Village, Tirtoyudo District, Malang Regency, it is increasingly real for the whole community, this can be seen from the existence of enhancement income per capita community , both from ari sector agriculture , industry , and services have been able to change civilization tour structure as well as the social strata of the local community.Keywords: Government Village; Village Fund Allocation’ Village DevelopmentPercepatan dalam pelaksanaan pembangunan tentunya membutuhkan anggaran yang sumber pendanaannya selalu siap bekerja. Hal ini secara langsung akan mempengaruhi kesejahteraan sosial, ekonomi, serta pendidikan bagi masyarakat Desa Taman Kuncaran, Kecamatan Tirtoyudo, Kabupaten Malang. Fokus penelitian adalah Peran Pemerintah Desa dalam Alokasi Dana Desa sebagai upaya peningkatan pembangunan. Hasil penelitian menunjukkan bahwa dengan realisasi Alokasi Dana Desa (ADD); struktur pembangunan sosial, ekonomi, dan pendidikan dapat menyentuh seluruh lapisan masyarakat, kesejahteraan sosial dan ekonomi, bagi masyarakat Desa Taman Kuncaran Kecamatan Tirtoyudo Kabupaten Malang semakin nyata bagi seluruh masyarakat, hal ini terlihat dari Adanya peningkatan pendapatan perkapita masyarakat, baik dari sektor pertanian, industri, maupun jasa telah mampu mengubah struktur wisata peradaban maupun strata sosial masyarakat setempat.Kata kunci: Anggaran Dana Desa; Pemerintah Desa; Pembangunan Desa
PENGEMBANGAN SOAL IPA MATERI SIKLUS AIR BERBASIS LITERASI SAINS MENGGUNAKAN APLIKASI QUIZIZ UNTUK KELAS V SEKOLAH DASAR
Authors: Wibowo Andi , Yunia Rista
Published: August 2022

Tujuan penelitian ini adalah: (1) dapat mengembangkan soal berbasis literasi sains melalui aplikasi quiziz untuk kelas V SD (2) mengetahui valid dan reliabel dalam soal pilihan ganda (3) mengetahui kelayakan pada instrumen soal literasi sains (4) mengetahui respon siswa terhadap kemenarikan pada pengembangan soal berbasis literasi sains dengan menggunakan aplikasi quiziz. Model pengembangan yang digunakan adalah model ADDIE. Subjek penelitian merupakan siswa kelas V SDN Bringin 2 Wajak dengan jumlah 20 siswa pada uji coba lapangan. Prosedur penelitian diantaranya tahap analisis, perancangan, pengembangan, implementasi dan evaluasi. Teknik yang digunakan dalam pengumpulan data adalah wawancara, observasi, angket, dokumentasi. Instrument yang diadalah lembar pedoman wawancara, lembar angket validasi. Hasil yang didapat pada ahli instrumen dan ahli media yaitu ahli media mendapatkan presentase 98% dengan kategori “Sangat Layak”, ahli instrument mendapatkan presentase 98% dengan kategori “Sangat Layak”, respon guru mendapatkan presentase 96,3% dengan kategori “Sangat Layak”, respon Siswa kelompok kecil mendapatkan presentase 4,00% dengan kategori “Sangat Layak”.  Hasil uji coba lapangan presentase yang didapat 3,93 “sangat menarik”.
PENGEMBANGAN MEDIA BUSA SEDAP (BUKU SAKU SUMBER ENERGI DAN PERUBAHAN) TEMATIK UNTUK MENINGKATKAN MOTIVASI BELAJAR SISWA KELAS III SEKOLAH DASAR
Authors: Yanti Yulia Eka , Himmah Nur Faizah Nafiatul
Published: August 2022

Penelitian ini bertujuan untuk mengetahui motivasi belajar siswa kelas III sekolah dasar dengan mengaplikasikan media yang diberi nama Busa Sedap yang valid dan dapat digunakan  juga dapat membantu siswa.Penelitian ini menggunakan metode penelitian RnD (Research and Development). Prosedur penelitian pengembangan yang dillakukan mengadaptasi model pengembangan Borg&Gall yang terdiri dari 9 tahap: 1) potensi dan masalah, 2) pengumpulan data, 3) desain produk, 4) validasi produk, 5) revisi produk, 6) uji coba produk terbatas, 7) revisi produk II, 8) uji coba produk utama, 9) revisi produk III. Subjek pada penelitian ini adalah 15 siswa kelas III SD NU Hasanuddin Dilem 02. Teknik pengumpulan data, peneliti menggunakan instrumen penelitian meliputi: wawancara, angket motivasi, angket keterbacaan,serta dokumentasi. Hasil analisis data penilaian media Busa Sedap oleh validator menunujukkan persentase 98,6%. Sedangkan hasil validasi ahli materi menghasilkan persentase 92,5%. Dari keseluruhan hasil validasi tersebut menunjukkan bahwa media busa sedap layak dan valid untuk digunakan dalam proses pembelajaran. Hasil angket motivasi belajar yang diperoleh dari angket before diperoleh hasil 33,2%, sedangkan angket motivasi belajar after  diperoleh hasil 75% maka diperoleh peningkatan sebanyak 41,8%. Berdasarkan hasil dari penelitian tersebut, maka dapat disimpulkan bahwa penggunaan media busa sedap dapat memotivasi belajar siswa.
PENGEMBANGAN MEDIA PEMBELAJARAN VIDAM (VIDEO ANIMASI) PEMBELAJARAN TEMATIK UNTUK MENINGKATKAN MINAT BELAJAR SISWA KELAS 3 SD
Authors: Cholifah Tety Nur , Saputro Galih Ilham
Published: August 2022

Penelitian ini dilatarbelakangi oleh kurangnya minat siswa dan pemanfaatan media pembelajaran video khususnya pada pembelajaran tematik kelas 3 SDN 05 Balesari. Adapun tujuan dilakukannya penelitian ini yaitu: (1) Mengembangkan media berbasis video animasi dalam proses pembelajaran, (2) Mengetahui kelayakan video animasi pada penerapan saat proses pembelsajaran apakah mampu meningkatkan minat belajar siswa atau tidak. Penelitian ini menggunakan jenis penelitian RnD (Research and Development) dengan menggunakan model pengembangan ADDIE. Produk yang dikembangkan yaitu media VIDAM (Video Animasi), subjek dalam penelitian ini adalah siswa kelas 3 SDN 05 Balesari dengan jumlah 13 siswa. Teknik dan instrumen yang digunakan adalah wawancara, observasi, angket, dan dokumentasi. Untuk mengukur peningkatan minat menggunakan teknik before after. Hasil penelitian menunjukkan bahwa media VIDAM (Video Animasi) layak digunakan sebagai medi pembelajaran dengan validasi ahli materi sebesar 100% dengan kriteria sangat layak, validasi ahli media 1 sebesar 82% dengan kriteria valid, dan validasi ahli media 2 sebesar 98% dengan kriteria sangat valid. Media VIDAM dapat meningkatkan minat belajar siswa, hal ini dapat dilihat dari hasil angket minat siswa dimana pada kelompok kecil hasil minat before sebesar 61% dan after sebesar 87% sehingga peningkatan minat belajar pada kelompok kecil sebesar 26%, sedangkan pada kelompok besar hasil minat before sebesar 62,25% dan after 88,25% sehingga peningkatan minat belajar pada kelompok besar sebesar 26%. Dari hasil tersebut dapat disimpulkan bahwa media VIDAM dapat meningkatkan minat belajar siswa kelas 3 SDN 05 Balesari.
PENGGUNAAN MEDIA KARTU GAMBAR UNTUK MENINGKATKAN KETERAMPILAN MEMBACA SISWA DALAM PEMBELAJARAN TEMATIK DI KELAS 2 SDN 01 LANDUNGSARI
Authors: Safitri Amita , Mukhlishina Innany
Published: August 2022

Penelitian ini dilatarbelakangi karena kurangnya minat membaca siswa serta kurangya kemampuan siswa dalam keterampilan membaca, semua itu karna keterampilan membaca merupakan kemampuan membaca dengan baik dan benar dan juga kemampuan yang harus di miliki oleh setiap orang. Tidak hanya keterampilan membaca saja yang penting akan tetapi keterampilan menulis, berbicara, dan mendengarkan juga penting bagi kehidupan sehari- hari. Keterampilan membaca ini juga sangat penting dalam pembelajaran tematik. Dalam pembelajaran tematik terdapat tema dan subtema dan di dalamnya harus memuat kompetensi dasar (KD) dan kompetensi inti (KI).  Penggunaan media pembelajaran sangatlah penting untuk mendukung suatu kegiatan pembelajaran agar mencapai suatu tujuan yang telah di rencanakan.  Penelitian ini bertujuan untuk mengetahui bagaimana perkembangan pembelajaran dalam keterampilan membaca siswa  di kelas 2 SDN 01 Landungsari, dan untuk mengetahui bagaimana penerapan atau pengguanaan media kartu gambar dalam meningkatkan keterampilan membaca pada siswa kelas 2 SDN 01 Landungsari. Dan subjek dalam penelitian ini yaitu siswa kelas 2 SDN 01 Landungsari, dan metode yang di gunakan dalam penelitian ini yaitu penelitian Tindakan kelas (PTK) dan pengamatan dengan melakukan observasi awal dan pedoman wawancara. Berdasarkan hasil dari penelitian termasuk hasil dari kedua siklus bahwa dengan menggunakan media kartu gambar tidak sepenuhnya meningkatkan keterampilan membaca siswa kelas 2 SDN 01 Landungsari, semua itu harus di imbangi dengan usaha keras dari seorang guru saat memberikan pengajaran dan sebuah dorongan atau dukungan dari orang-orang terdekatnya.
redes sociales como estrategia de internacionalización de las MIPYMES de el Oro
Authors: Armijos-Morocho Naomi Paulett , Benítez-Luzuriaga Francisco Vladimir
Published: August 2022

El presente estudio evidencia el análisis de las redes sociales y la incidencia que tiene en el proceso de internacionalización de las PYMES en la ciudad de Machala a través de evaluaciones estadísticas en el software SPSS, el objetivo de la investigación se basó en estudiar por medio de un modelo investigativo la significancia relacional de las variables objetivo de la investigación, se usó una estructura metodológica cuantitativa con alcance correlacional, en una muestra de 50 PYMES de la ciudad de Machala en proceso de internacionalización. Como resultado del estudio se obtuvo respuestas que difieren de las hipótesis, entendiendo así el comportamiento de las estrategias en los negocios y cómo las redes sociales afectan a estos procesos, se obtuvo valoraciones no esperadas, concluyendo que la gestión de las redes sociales está subdesarrollada y funcionan como complemento de estrategias de marketing muy bien gestionadas.
A Inteligência Artificial a favor da aprendizagem dos alunos com deficiência
Authors: Gonçalo Camilla Viana de Souza , Carvalho Aline dos Santos Moreira de , Araújo Antônio Marcondes de
Published: August 2022

A Inteligência Artificial inserido no setor educacional proporciona ao deficiente um  aprendizado diferenciado, o ajudando a aumentar o engajamento do aluno. Isso porque são diferentes recursos de tecnologia disponibilizados a qualquer momento, como a gamificação, que elevam o interesse do estudante pela educação, dessa  essa estratégia transforma os alunos em protagonistas com habilidades fundamentais e mais conhecimento. Com cada vez mais invenções disponíveis online que não sejam trazidas apenas pelo educador, a Inteligência Educacional é uma boa ideia para os alunos aprenderem do lugar onde estiverem. Além de estimular o aprendizado, é possível criar sistemas personalizados com o perfil de cada aluno. A referida pesquisa baseia-se em dados bibliográficos, elaborada a partir de material já publicado, como livros, artigos, periódicos, internet, e em dados qualitativos vez que que visa abordar os aspectos subjetivos de fenômenos sociais e do comportamento humano procurando, deste modo, abordar temas que não podem ser quantificados em equações e estatísticas, de base metodológica de paradigma sistêmico, pautada na teoria da complexidade tendo como objeto de estudo as inteligências artificiais inseridas nos ambientes educacionais como promoção de aprendizagem.
Visão da fisioterapia em relação as doenças neurológicas causadas pelo esporte
Authors: Santos Patrick Pablo Souza dos , Costa Alexandre Rodrigues da , Silva Karla Camila Correia da
Published: August 2022

Introdução: Saúde e bem-estar são preocupações cada vez mais frequentes na sociedade moderna e a prática de esportes constituem um ponto fundamental nessa rotina. Ao longo do último século, podemos ver um grande crescimento na variedade de esporte radical, como boxe, lutas livres (artes marciais livres e futebol) e na quantidade de participantes. Estes esportes são de grande impacto e mesmo as modalidades mais tradicionais ganham novos adeptos dia após dia, e com isso o número de lesões relacionadas ao esporte cresce. Objetivo: Estabelecer qual é atuação do fisioterapeuta no tratamento das lesões esportivas do esporte. Metodologia: Revisão de artigos, relacionados ao estudo de conhecimentos específicos dos fisioterapeutas sobre prevenção de patologias ocorridas nos esportes. Resultados: O fisioterapeuta tem conhecimentos específicos sobre a reabilitação do atleta e sobre esportes e, como tal, estão mais aptos a ajudar os atletas a se recuperarem rapidamente. As lesões causadas pelo esporte ocorrem durante a participação em competições ou até mesmo durante as sessões de treinamento. A atuação do fisioterapeuta no tratamento dessas lesões esportivas do crânio cerebral, causadas pelos traumas ou choque devido à velocidade do impacto e a agressividade do esporte, se torna cada vez mais favorável. Conclusão: Uma forte relação atleta-fisioterapeuta é necessária para o tratamento eficaz e a definição das expectativas dos atletas em relação à reabilitação de lesões quando possível.
Lip filling associated with subcision in a patient with cleft lip and palate
Authors: Serratine Paula Lopes , Barbosa Kledson Lopes
Published: August 2022

To describe a case of lip filling associated with subcision of the ligaments of the orbicularis oris muscle and the superficial musculoaponeurotic system (SMAS) of a patient with cleft lip and palate. Case details: A 42-year-old woman was seen at a dental clinic specializing in orofacial harmonization (Instituto Erlacher) with a complaint of lip asymmetry. She reported being born with cleft lip and palate and being submitted to surgical intervention by an oral and maxillofacial surgeon. After clinical evaluation and planning, a subcision technique was performed prior to lip filling with hyaluronic acid, with the objective of maintaining good tissue integration of the product, avoiding its migration to other regions, and reducing local resistance due to scar fibrosis. Final considerations: This study revealed that even though it is not a definitive procedure, which requires periodic maintenance, the minimally invasive treatment with the injection of hyaluronic acid through the subcision technique is capable of immediately correcting the lip asymmetry of patients with cleft lip and palate. looking for the procedure.
Reflexões freirianas e educação permanente em saúde na central de regulação em prol do acesso à saúde
Authors: Campos Carina Corrêa Bonates , Santos Natânia Candeira dos , Cortez Elaine Antunes
Published: August 2022

Este estudo objetiva refletir à luz de Paulo Freire sobre a possibilidade de conectar a prática assistencial em Central de Regulação com a Educação Permanente de forma a contribuir para a melhoria do acesso aos serviços do SUS. Trata-se de uma reflexão teórica com abordagem qualitativa, ancorada nos preceitos políticos da Educação Permanente em Saúde e à luz de Paulo Freire. Ao sistematizar ideais educacionais que proponham construção reflexiva embasada por um processo de ação-reflexão, obtém-se a problematização necessária para explorar uma rede analisadora do processo de trabalho exercido no contexto laboral das Centrais de Regulação. A estratégia educacional permanente, concretiza e impulsiona a geração de conhecimento direcionando ações e transformações da realidade em ambientes de aprendizagem significativa embasados na dialogicidade entre pares. Frente à realidade advinda do modelo de atenção fragmentado aos quais fazem parte o cotidiano dos serviços de saúde brasileiros, encontramos na filosofia Freiriana, a motivação para repensar sobre a importância de sua prática em detrimento da problematização de pontos sensíveis e assim produzir estratégias de ação rumo a construção colaborativa e horizontalizada entre os atores desse processo na busca por uma saúde digna, justa e equânime.
Biometria de frutos, sementes e plântulas de Cenostigma tocantinum Ducke
Authors: Diniz Adriane Yasmin de Sena , Oliveira Thiago Nascimento de , Quadros Bárbara Rodrigues de , Pamplona Vanessa Mayara Souza , Ribeiro Olívia Domingues , Castro Wayla Carolina Pimentel de , Azevedo Ester Mota de Lima de , Cruz Hemilli Taynara Gomes da , Santos Maria Júlia Silva dos , Nascimento Marcos Simehonne Castro do
Published: August 2022

As espécies arbóreas têm potencial para aproveitamento em diversos setores e cadeias produtivas. Neste contexto, a biometria constitui-se em uma importante ferramenta para identificar as principais características intrínsecas ao fruto e a semente. Portanto, objetivou-se com este estudo caracterizar biometricamente os frutos, sementes e plântulas da espécie Cenostigma tocantinum Ducke, de modo a obter informações sobre a variação das características. Para a avaliação da biometria foram utilizados 100 frutos frescos de diferentes árvores matrizes. As características avaliadas foram: comprimento, largura e espessura de fruto e sementes, peso dos frutos, número de sementes por fruto, emergência de plântulas, comprimento da parte aérea, raiz principal e total das plântulas. Constatou-se variabilidade paras os caracteres biométricos relacionados as dimensões e pesos de frutos de Cenostigma tocantinum. O percentual de emergência das plântulas foi de 98%. Os resultados encontrados nesse estudo podem auxiliar na diferenciação e identificação da espécie, fornecendo dados biométricos de importantes características botânicas e da espécie no estágio inicial do crescimento.
Peanut ball use for reducing maternal fatigue during labor: protocol for a randomized clinical trial
Authors: Delgado Alexandre Magno , Silva Rita de Cassia Barros da , Medeiros Patrícia Juliana Alves de , Melo Renato de Souza , Oliveira Andrea Lemos Bezerra de
Published: August 2022

Objectives: Develop a protocol of the use of the Peanut Ball (PB) to evaluate its effectiveness compared to usual care on decreasing maternal fatigue during labor. Methods: This is the development of a randomized clinical trial protocol. Perform an intervention group or use the Peanut Ball through five postures, according to an obstetric assessment. To assess maternal fatigue, the Maternal Perception of Childbirth Fatigue Questionnaire (MCFQ) will be used in the form of an interview. Results: The proposed protocol is according to the evolution of labor: height and positioning of the fetal presentation, erasure and uterine dilation and the presence of early blood flow. Postures with fetal presentation in the upper strait: postures with abduction and external rotation hips will be encouraged using PB. Posture according to the fetal position in the upper strait: posture that cancels gravity will be encouraged: lateral decubitus posture with PB between legs. If the parturient feels like pushing or pushing down with the baby tall and cervix before 8-10 centimeters of uterine dilation, posture that nullifies gravity will be encouraged: lateral decubitus with the aid of the ball, with the hips in abduction and external rotation Conclusion: A specific protocol was developed with the use of Peanut Ball, through an obstetric evaluation, to reduce maternal fatigue during labor.
Korelasi Antara Indeks Masa Tubuh (Imt) Dengan Kemampuan Mengecap Phenylthiocarbamide (Ptc) Pada Mahasiswa Fakultas Kedokteran Universitas Yarsi Angkatan 2019
Authors: Purwaningsih Endang , Mirfat Mirfat , Widayanti Etty
Published: August 2022

Gangguan pengecapan terhadap phenylthiocarbamide (PTC) merupakan suatu sifat yang diwariskan dan berpengaruh terhadap preferensi makanan serta diet. Hal ini akan berpengaruh terhadap berat badan/adipositas yang berperan sebagai kontributor terhadap berbagai komorbid seperti obesitas.  Obesitas merupakan salah satu penyebab utama berbagai komplikasi kesehatan di negara-negara berkembang terutama pada orang dewasa. Tujuan penelitian adalah mengetahui korelasi antara Indeks Masa Tubuh dengan kemampuan mengecap phenylthiocarbamide (PTC) pada mahasiswa Fakultas Kedokteran Universitas YARSI Angkatan 2019.Metode penelitian adalah kuantitatif dengan jenis penelitian eksperimental dan rancangan cross sectional. Subyek diintruksikan untuk menjulurkan lidahnya, dan diteteteskan larutan phenylthiocarbamide di bagian tengah lidah. Kemudian ditanya, apa yg dia rasakan, pahit atau tidak pahit. Pengumpulan data tentang berat badan dan tinggi badan dilakukan dengan cara kuisioner.Hasil penelitian menunjukkan sebagian besar mahasiswa Fakultas Kedokteran Universitas YARSI Angkatan 2019 memiliki rata-rata Berat Badan, Tinggi Badan dan Indeks Masa Tubuh (IMT) masing-masing adalah sebesar 61,1888 kg kurang lebih 15,4728, 162,74 cm kurang lebih 0,1018 dan 23,0426 kurang lebih 5,0450. Menurut klasifikasi WHO sebagian besar sampel memiliki berat badan ideal. Dari pengujian PTC didapatkan insidensi kelompok taster sebesar 71, 5 % dan kelompok nontaster sebesar 28,5 %. Tidak ada korelasi yang signifikan antara IMT dengan kemampuan sebagai taster atau non taster (p lebih besar dari 0,05).Disimpulkan bahwa kemampuan mengecap PTC tidak mempengaruhi Indeks Masa Tubuh (IMT) pada mahasiswa FK Universitas YARSI Angkatan 2019. Sebagian besar mahasiswa memiliki Indeks Masa Tubuh ideal
Intra- and inter-annual shifts in foraging tactics by parental northern gannets Morus bassanus indicate changing prey fields
Authors: d’Entremont KJN , Davoren GK , Walsh CJ , Wilhelm SI , Montevecchi WA
Published: August 2022

Seabirds are constrained by central-place foraging during breeding, when the energy obtained from prey must outweigh the costs of travel, search, capture and transport. The distribution and phenology of the cold-blooded marine fishes they exploit are heavily influenced by oceanic climate. Northern gannets, the largest breeding seabird in the North Atlantic, use a generalist foraging strategy, preying on a wide array of pelagic fishes. They employ different foraging tactics for different prey types, with rapid, shallow V-shaped dives used for large, powerful prey such as mackerel, and U-shaped dives for smaller forage fishes like capelin. Here we assess intra- and inter-annual differences in foraging effort and influences of prey availability at the southernmost colony of the species at Cape St. Mary’s, Newfoundland, Canada. We compared foraging trip characteristics (total and maximum distance, directness, duration and number of dives) of parental gannets during the breeding seasons of 2019 (n = 10) and 2020 (n = 7) using GPS/time-depth recorders. Individual gannets shifted away from using U-shaped dives in early chick-rearing to primarily V-shaped dives in late chick-rearing. Shifts were abrupt and occurred in mid-August in 2019 and 2020. Maximum and total foraging trip distance and duration were significantly greater during early chick-rearing in 2020 than in 2019. Kernel density 50% utilization distributions were larger and expanded further from the colony during early chick-rearing in 2020 (7297 ± 1419 km2; mean ± SE) than 2019 (2382 ±797 km2). Increased foraging effort during early chick-rearing in 2020 was likely due to decreased capelin availability, resulting from earlier spawning, and greater variation in the timing of spawning among sites, which may have been influenced by warmer waters.
Loss of suitable ocean habitat and phenological shifts among grouper and snapper spawning aggregations in the Greater Caribbean under climate change
Authors: Gokturk EN , Bartlett BS , Erisman B , Heyman W , Asch RG
Published: August 2022

Phenological shifts have been observed among marine species due to climate change. Modeling changes in fish spawning aggregations (FSAs) under climate change can be useful for adaptive management, because it can allow managers to adjust conservation strategies in the context of specific life history and phenological responses. We modeled effects of climate change on the distribution and phenology of Caribbean FSAs, examining 4 snapper and 4 grouper species. An ecological niche model was used to link FSAs with environmental conditions from remote sensing and project FSA distribution and seasonality under RCP8.5. We found significant differences between groupers and snappers in response to warming. While there was variation among species, groupers experienced slight delays in spawning season, a greater loss of suitable ocean habitat (average loss: 72.75%), and poleward shifts in FSA distribution. Snappers had larger shifts towards earlier phenology, with a smaller loss of suitable ocean habitat (average loss: 24.25%), excluding gray snapper, which gained habitat. Snappers exhibited interspecific variability in latitudinal distribution shifts. Snapper FSAs appeared more resilient to climate change and occupy wider and warmer spawning temperature ranges, while groupers prefer cooler spawning seasons. Consequently, groupers may lose more suitable ocean spawning habitat sooner due to climate change. When comparing species, there were trade-offs among climate change responses in terms of distribution shifts, phenology changes, and declines in habitat suitability. Understanding such trade-offs can help managers prioritize marine protected area locations and determine the optimal timing of seasonal fishing restrictions to protect FSAs vulnerable to fishing pressure in a changing climate.
Semaglutide: A Strategic Weapon for Primary Care
Authors: Jain Akshay
Published: August 2022

Type 2 diabetes has been a long-standing concern worldwide and in Singapore. Having one of the highest diabetes prevalence rates in Southeast Asia, Singapore has explored various ways of enhancing the management of chronic illnesses, one of which is to treat diabetic patients in primary care settings rather than speciality facilities. Primary care physicians are tasked to manage their diabetic patients’ glycated haemoglobin levels, along with a myriad of related complications including hypoglycaemia, cardiovascular risk, and body weight issues. With the ever-increasing complexity of population health demands, oral semaglutide can be a strategic weapon utilised by primary care doctors to treat type 2 diabetic patients. In terms of glycaemic control and body weight reduction, oral semaglutide has outperformed several other oral anti-diabetic medicines. Moreover, oral semaglutide has a proven cardiovascular safety profile with potential benefits. The development of oral semaglutide, rather than the injectable type, has made it simpler for patients to benefit from semaglutide treatment. Oral semaglutide is a feasible and effective strategy in type 2 diabetes management, for both initiation and intensification needs, and is well positioned to be a game changer in primary care.
Cem Anos de Solidão e Viver para Contar, de Gabriel García Márquez: expressões de identidade sociocultural latinoamericana
Authors:   UEMG - Universidade do Estado de Minas Gerais - Unidade Frutal, Pessoa Marcelo
Published: August 2022

Our work investigates post-colonialism categories in the works One Hundred Years of Solitude and Live to Count. The pillars of our search are fictional and biographical images constituents of the works in question. Such references are focused as expressions sociocultural aspects of the Latin American people. Our interest in the work One Hundred Years of Solitude, by Gabriel García Márquez, is related to the fact that this literary production represents strong elements of contemporary Latin American context. Likewise, we realize that the author, in the literary manifestation of signs of Latinity, makes use of elements consistent with the acculturation to which the Latin American people submitted, as we can see in their biographical work Living to Tell. In Viver para Contar, the experience report reveals that the Latin American singularity is focused on the interface with the European or North American “other”. From these two paradigms emerges the allegorical figure of the neo-colonizer represented by the different dynamics of capital oppression, highlighting the different ways in which singularities were glimpsed in the world and from which they began to interact and metamorphose reciprocally. Finally, it is seen that these connections, among other things, bring out the profile of Latin Americans that we believe to have and/or to be, thus composing a literary iconography1 of the Latin America
CULTURA SEXUAL E IMAGINÁRIO LITERÁRIO: FENÔMENOS CONTEMPORÂNEOS DE INCLUSÃO SOCIAL
Authors:   UEMG - Universidade do Estado de Minas Gerais - Unidade Frutal, Pessoa Marcelo
Published: August 2022

A work like ours, intends, through such issues in evidence at the University, to draw attention to a latent cultural behavior of historical reversal of the segregation imposed on individuals who were formerly called “inadequate” (and who still cause astonishment today). The scientific intervention is justified by the fact that this theme calls us to see the field of consumption and social coexistence, whether through digital television inclusion, or through the consumerist path of pink money. As partial results, our research detects that in our society, there is a huge range of social representations on the subject, which forced us to make a second option for the same objects of analysis, that is, to put literary representation as a comparison route. and the media, proposing a dialogue between a conservative and archaic past and a supposedly liberal and avant-garde present. One of the theoretical pillars that support us is Freud's study, entitled "Three Essays on the Theory of Sexuality", together with Lacan's, in the seminar "Desire and its interpretation".
PENERAPAN TEORI ADMINISTRASI PUBLIK DALAM KEBERLANJUTAN PENGELOLAAN IPAL KOMUNAL DI JAKARTA
Authors: Tanjung Fadly Haley
Published: August 2022

Program SANIMAS-IsDB diinisiasi oleh Kementerian PUPR tahun 2015-2018 dan Pemerintah Provinsi DKI Jakarta turut membangun IPAL Komunal di 23 lokasi. Data Bappenas (2018) menunjukkan bahwa 96% badan air di Jakarta tercemar berat dan menurut data Dinas Lingkungan Hidup tahun 2018, sumber pencemar air limbah terdapat di permukiman sekitar 72,7%. Untuk mengoperasional IPAL Komunal dengan baik, dibutuhkan manajemen pengelolaan yang baik dan berkelanjutan. Menurut Dinas PPAPP, IPAL Komunal yang berkinerja baik berlokasi di RW. 01, Kelurahan Rawajati, Pancoran, Jakarta. Indikator pengaruh keberlanjutan pengelolaan IPAL Komunal berkaitan dengan teori administrasi publik. Menurut Gulick dalam Ahmad (2015), teori tersebut dituangkan dalam aspek yang disebut POSDCORB (Planning, Organizing, Staffing, Directing, Coordinating, Reporting, Budgeting). Aspek pengelolaan tersebut perlu dikaji dengan limitasi dalam manajemen infrastruktur (Naipospos, 2019). Metode analisis data yang digunakan adalah kualitatif secara deskriptif, yang didahului dengan studi literatur. Hasil studi literatur diketahui bahwa indikator yang mempengaruhi keberlanjutan pengelolaan IPAL Komunal dan kaitannya dengan teori administrasi publik, yaitu: 1) Pentingnya peran stakeholders-berkaitan dengan aspek P, S, O dan C; 2) Biaya perawatan dan pemeliharaan-berkaitan dengan aspek O dan B; 3) Desain teknis-berkaitan dengan aspek P, dan 4) Aspek sosial-berkaitan dengan aspek R. Berdasarkan hasil analisis, disimpulkan bahwa pentingnya peran serta stakeholders, desain teknis IPAL dan aspek sosial warga merupakan indikator yang perlu dipertahankan khususnya aspek P, S, O, C dan R untuk mewujudkan pengelolaan IPAL Komunal yang berkelanjutan. Sedangkan indikator biaya perawatan dan pemeliharaan masih perlu diperbaiki dan ditingkatkan kinerjanya terkait aspek B dan belum menjadi prioritas dalam pengelolaan IPAL Komunal.
Transitioning peanut oral immunotherapy to clinical practice
Authors: Lazizi S. , Labrosse R. , Graham F.
Published: August 2022

Peanut allergy is on the rise in industrialized countries, affecting 1%–4.5% of children and generally persisting into adulthood. It is associated with a risk of severe anaphylaxis and is one of the major causes of food allergy-induced deaths. Health-related quality of life is significantly impaired for patients and affected families due to food restrictions attributable to omnipresent precautionary allergen labeling, constant risk of potentially life-threatening reactions, and limitation of social activities. Oral immunotherapy (OIT) has emerged as a valid treatment option for patients with IgE-mediated peanut allergy, with randomized controlled trials and real-life studies showing a high rate of desensitization and a favorable safety profile, especially in young children. Ultimately, the decision to initiate peanut OIT relies on a multidisciplinary shared decision-making process, involving open, personalized and evidence-based discussions with patients and their caregivers.
CuS nanoparticles and camptothecin co-loaded thermosensitive injectable hydrogel with self-supplied H2O2 for enhanced chemodynamic therapy
Authors: Tang Wenxue , Li Xiang , Liu Zeming , Meng Lyu , Zhu Daoming , Huang Qinqin
Published: August 2022

Chemodynamic therapy (CDT) is a kind of anti-tumor strategy emerging in recent years, but the concentration of hydrogen peroxide (H2O2) in the tumor microenvironment is insufficient, and it is difficult for a single CDT to completely inhibit tumor growth. Here, we designed a CuS nanoparticles (NPs) and camptothecin (CPT) co-loaded thermosensitive injectable hydrogel (SCH) with self-supplied H2O2 for enhanced CDT. SCH is composed of CuS NPs and CPT loaded into agarose hydrogel according to a certain ratio. We injected SCH into the tumor tissue of mice, and under the irradiation of near-infrared region (NIR) laser at 808 nm, CuS NPs converted the NIR laser into heat to realize photothermal therapy (PTT), and at the same time, the agarose hydrogel was changed into a sol state and CPT was released. CPT activates nicotinamide adenine dinucleotide phosphate oxidase, increases the level of H2O2 inside the tumor, and realizes the self-supply of H2O2. At the same time, CuS can accelerate the release of Cu2+ in an acidic environment and light, combined with H2O2 generated by CPT for CDT treatment, and consume glutathione in tumor and generate hydroxyl radical, thus inducing tumor cell apoptosis. The SCH system we constructed achieved an extremely high tumor inhibition rate in vitro and in vivo, presenting a new idea for designing future chemical kinetic systems.
A higher spectral range of beetle bioluminescence with infraluciferin
Authors: Jathoul Amit P. , Branchini Bruce R. , Anderson James C. , Murray James A. H.
Published: August 2022

Coleopteran bioluminescence is unique in that beetle luciferases emit colors ranging between green (ca.550 nm) and red (ca.600 nm), including intermediate colors such as yellow and orange, allowing up to 3 simultaneous parameters to be resolved in vitro with natural luciferin (D-LH2). Here, we report a more than doubling of the maximum bioluminescence wavelength range using a single synthetic substrate, infraluciferin (iLH2). We report that different luciferases can emit colors ranging from visible green to near-infrared (nIR) with iLH2, including in human cells. iLH2 was designed for dual color far-red to nIR bioluminescence imaging (BLI) in small animals and has been utilized in different mouse models of cancer (including a metastatic hepatic model showing detailed hepatic morphology) and for robust dual parameter imaging in vivo (including in systemic hematological models). Here, we report the properties of different enzymes with iLH2: Lampyrid wild-type (WT) Photinus pyralis (Ppy) firefly luciferase, Ppy-based derivatives previously engineered to be thermostable with D-LH2, and also color-shifted Elaterid-based enzymes: blue-shifted Pyrearinus termitilluminans derivative Eluc (reported D-LH2 λmax = 538 nm) and red-shifted Pyrophorus plagiopthalamus derivative click beetle red (CBR) luciferase (D-LH2 λmax = 618 nm). As purified enzyme, in bacteria or in human cells, Eluc emitted green light (λmax = 536 nm) with DL-iLH2 whereas Ppy Fluc (λmax = 689 nm), x2 Fluc (λmax = 704 nm), x5 Fluc (λmax = 694 nm), x11 Fluc (λmax = 694 nm) and CBR (λmax = 721 nm) produced far-red to nIR peak wavelengths. Therefore, with iLH2, enzyme λmaxes can be separated by ca.185nm, giving almost non-overlapping spectra. This is the first report of single-substrate bioluminescence color emission ranging from visible green to nIR in cells and may help shed light on the color tuning mechanism of beetle luciferases. We also report on the reason for the improvement in activity of x11 Fluc with iLH2 and engineer an improved infraluciferase (iluc) based on this mutant.
The extended effect of adsorbed damage-associated molecular patterns and Toll-like receptor 2 signaling on macrophage-material interactions
Authors: Kaushal Anuj , Zhang Yuxi , Ballantyne Laurel L. , Fitzpatrick Lindsay E.
Published: August 2022

Implanted biomaterials elicit an immune-mediated foreign body reaction (FBR) that results in the fibrous encapsulation of the implant and can critically impact the performance of some implants. Consequently, understanding the molecular mechanisms that underpin cell-materials interactions that initiate biomaterial-induced inflammation and fibrosis is critical to improving the performance of biomaterial implants negatively impacted by the FBR. Damage-associated molecular patterns (DAMPs) are endogenous mediators of inflammation that are released upon tissue injury and induce sterile inflammationviaToll-like receptors (TLRs). However, the prevalence of DAMPs within the adsorbed protein layer on material surfaces and their role mediating cell-material interactions is unclear. Previously, our group demonstrated that molecules in fibroblast lysates adsorbed to various biomaterials and induced a potent TLR2-dependent inflammatory response in macrophages at 24 h. In this study, we examined the extended response of RAW-Blue reporter macrophages on lysate or serum-adsorbed Teflon™ AF surfaces to understand the potential role of adsorbed DAMPs in macrophage-material interactions at later time points. Lysate-conditioned surfaces maintained increased nuclear factor kappa B (NF-κB) and activator protein 1 (AP-1) transcription factor activity and increased expression Regulated upon Activation, Normal T Cell Expressed and Presumably Secreted (RANTES/CCL5) at 72 h and 120 h, compared to FBS-conditioned surfaces. In contrast, monocyte chemoattractant protein 1 (MCP-1/CCL2) was only elevated at 72 h in lysate conditions. Transforming growth factor beta 1 (TGF-β1) secretion was significantly increased on lysate-conditioned surfaces, while conditioned media from macrophages on lysate-conditioned surfaces induced alpha smooth muscle actin (αSMA) expression in 3T3 fibroblasts. TLR2 neutralizing antibody treatment significantly decreased NF-κB/AP-1 activity and attenuated TGF-β1 expression at both time points, and MCP-1 and RANTES at 72 h. Finally, multinucleated cells were observed on lysate-conditioned surfaces at 72 h, indicating adsorbed DAMPs induced a fusion permissive environment for adherent macrophages. This study demonstrates that adsorbed DAMPs continue to influence macrophage-material responses beyond the initial 24-h period and maintain a pro-inflammatory and fibrotic response that models aspects of the early FBR. Furthermore, the transient inhibition of TLR2 continued to exert an effect at these later time points, suggesting TLR2 may be a target for therapeutic interventions in FBR.
Endothelial cells during craniofacial development: Populating and patterning the head
Authors: Asrar Hiba , Tucker Abigail S.
Published: August 2022

Major organs and tissues require close association with the vasculature during development and for later function. Blood vessels are essential for efficient gas exchange and for providing metabolic sustenance to individual cells, with endothelial cells forming the basic unit of this complex vascular framework. Recent research has revealed novel roles for endothelial cells in mediating tissue morphogenesis and differentiation during development, providing an instructive role to shape the tissues as they form. This highlights the importance of providing a vasculature when constructing tissues and organs for tissue engineering. Studies in various organ systems have identified important signalling pathways crucial for regulating the cross talk between endothelial cells and their environment. This review will focus on the origin and migration of craniofacial endothelial cells and how these cells influence the development of craniofacial tissues. For this we will look at research on the interaction with the cranial neural crest, and individual organs such as the salivary glands, teeth, and jaw. Additionally, we will investigate the methods used to understand and manipulate endothelial networks during the development of craniofacial tissues, highlighting recent advances in this area.
Transcriptomic analysis provides a new insight: Oleuropein reverses high glucose-induced osteogenic inhibition in bone marrow mesenchymal stem cells via Wnt10b activation
Authors: Lao An , Chen Yu , Sun Yiting , Wang Tiange , Lin Kaili , Liu Jiaqiang , Wu Jianyong
Published: August 2022

Adverse events of diabetes mellitus (DM) include bone damages, such as the increased incidence of osteoporosis and bone fractures, which are known as diabetic osteopathy. The pathogenic mechanism of diabetic osteopathy is complex, and hyperglycemia is a vital cause involved in it. Bone marrow mesenchymal stem cells (BMSCs) exert a significant effect on bone formation. Therefore, in this paper, transcriptomic changes of BMSCs cultured in high glucose (35 mM) for 30 days are mainly investigated. In addition, 794 up-regulated genes and 1,162 down-regulated genes were identified. Then, biological functions of the differentially expressed genes in the high glucose microenvironment were investigated by two kinds of functional analyses. Gene Set Enrichment Analysis was also applied to focus on the significant gene sets and it is found that Wnt10b expression witnessed a remarkable decrease in BMSCs under the high glucose microenvironment. At last, in vitro experiments revealed that oleuropein effectively reversed high glucose-induced osteogenic inhibition via activating Wnt10b in BMSCs.
To join or not to join?–A framework for the evaluation of enterprise blockchain consortia
Authors: Schwarzer Max , Gürpinar Tan , Henke Michael
Published: August 2022

Within the past years, enterprise blockchain solutions were frequently developed within different industry consortia. In most cases, this resulted in isolated solutions competing against each other due to similar approaches and goals. Today, decision makers do not necessarily need to establish entirely new blockchain consortia, as established ones already exist, and participation is a considerable way to avoid unreasonable efforts. In this paper, we apply an iterative literature review to identify different factors relevant for practitioners, who face the challenge of joining an existing enterprise blockchain consortium. In a second step, we discuss these factors utilizing supply chain management as a role model. As a main finding, we propose an evaluation framework for the purpose of enterprise blockchain consortium analysis. Additionally, we provide several questions relevant for practitioners during their evaluation stages. With our evaluation framework we contribute to blockchain research, where - despite its high relevance - the topic of consortium evaluation has so far been neglected. We also contribute to research in the field of technology evaluation by proposing and merging five different evaluation dimensions.