bluuebunny/crossref_metadata_2025 huggingface dataset:
Rapid and sensitive RPA-Cas12a-fluorescence assay for point-of-care detection of African swine fever virus
Authors: Fu Jinyu , Zhang Yueping , Cai Guang , Meng Geng , Shi Shuobo
Published: July 2021

African swine fever (ASF) is a serious contagious disease that causes fatal haemorrhagic fever in domestic and wild pigs, with high morbidity. It has caused devastating damage to the swine industry worldwide, necessitating the focus of attention on detection of the ASF pathogen, the African swine fever virus (ASFV). In order to overcome the disadvantages of conventional diagnostic methods (e.g. time-consuming, demanding and unintuitive), quick detection tools with higher sensitivity need to be explored. In this study, based on the conserved p72 gene sequence of ASFV, we combined the Cas12a-based assay with recombinase polymerase amplification (RPA) and a fluorophore-quencher (FQ)-labeled reporter assay for rapid and visible detection. Five crRNAs designed for Cas12a-based assay showed specificity with remarkable fluorescence intensity under visual inspection. Within 20 minutes, with an initial concentration of two copies of DNA, the assay can produce significant differences between experimental and negative groups, indicating the high sensitivity and rapidity of the method. Overall, the developed RPA-Cas12a-fluorescence assay provides a fast and visible tool for point-of-care ASFV detection with high sensitivity and specificity, which can be rapidly performed on-site under isothermal conditions, promising better control and prevention of ASF.
Coexistence of risk factors for cardiovascular diseases among Brazilian adolescents: Individual characteristics and school environment
Authors: Rodrigues da Silva Thales Philipe , Matozinhos Fernanda Penido , Gratão Lucia Helena Almeida , Rocha Luana Lara , Vilela Luisa Arantes , Oliveira Tatiana Resende Prado Rangel de , de Freitas Cunha Cristiane , Mendes Larissa Loures
Published: July 2021

Cardiovascular diseases (CVD) share common and modifiable risk factors; among them, unhealthy eating, physical inactivity, alcohol intake and smoking habit. However, these factors are not observed in separate and, most often, they influence each other. Risk factors established during adolescence are highly likely to remain in adult life. The aims of the current study were to evaluate the prevalence and coexistence of risk factors for CVD, as well as to investigate individual characteristic of the adolescent and environmental factors associated with risk factors’ coexistence profiles. This was a cross-sectional, national, school-based epidemiological study that estimated the prevalence of cardiovascular risk factors and metabolic syndrome in adolescents aged 12 to 17 years who attended public and private schools located in Brazilian counties with a population of more than 100 thousand. For this study, thematic blocks referring to alcohol consumption, eating habits, smoking, and physical activity were used. The grade of membership method was used to identify the coexistence of risk and protective factors for CVD among adolescents. The study analytical sample comprised 71,552 adolescents. Multilevel logistic regression was used to assess the association between factors influencing the coexistence profile of risk factors for CVD. Based on adolescent-level variables, has shown that meeting positive criterion for Common Mental Disorders and not consuming the meals provided by the school have significantly increased the likelihood of belonging to the CVD-risk profile. On the other hand, school-level variables, show that studying in private schools and living in economically favored Brazilian regions have increased adolescents’ likelihood of belonging to the CVD-risk profile. These results can be used to substantiate the inclusion of food environment variables in public policies focused on preventing CVD development among Brazilian adolescents.
Skeletal muscle mass at C3 may not be a strong predictor for skeletal muscle mass at L3 in sarcopenic patients with head and neck cancer
Authors: Yoon Joon-Kee , Jang Jeon Yeob , An Young-Sil , Lee Su Jin
Published: July 2021

Purpose

To evaluate the feasibility of using skeletal muscle mass (SMM) at C3 (C3 SMM) as a diagnostic marker for sarcopenia in head and neck cancer (HNC) patients.

Methods

We evaluated 165 HNC patients and 42 healthy adults who underwent 18F-fluorodeoxyglucose positron emission tomography/computed tomography scans. The paravertebral muscle area at C3 and skeletal muscle area at L3 were measured by CT. Pearson’s correlation was used to assess the relationship between L3 and C3 SMMs. The prediction model for L3 SMM was developed by multiple linear regression. Then the correlation and the agreement between actual and predicted L3 SMMs were assessed. To evaluate the diagnostic value of C3 SMM for sarcopenia, the receiver operating characteristics (ROC) curves were analyzed.

Results

Of the 165 HNC patients, 61 (37.0%) were sarcopenic and 104 (63.0%) were non-sarcopenic. A very strong correlation was found between L3 SMM and C3 SMM in both healthy adults (r = 0.864) and non-sarcopenic patients (r = 0.876), while a fair association was found in sarcopenic patients (r = 0.381). Prediction model showed a very strong correlation between actual SMM and predicted L3 SMM in both non-sarcopenic patients and healthy adults (r > 0.9), whereas the relationship was moderate in sarcopenic patients (r = 0.7633). The agreement between two measurements was good for healthy subjects and non-sarcopenic patients, while it was poor for sarcopenic patients. On ROC analysis, predicted L3 SMM showed poor diagnostic accuracy for sarcopenia.

Conclusions

A correlation between L3 and C3 SMMs was weak in sarcopenic patients. A prediction model also showed a poor diagnostic accuracy. Therefore, C3 SMM may not be a strong predictor for L3 SMM in sarcopenic patients with HNC.
Association of Tdap vaccine guidelines with vaccine uptake during pregnancy
Authors: DiTosto Julia D. , Weiss Rebecca E. , Yee Lynn M. , Badreldin Nevert
Published: July 2021

Objective

In 2012, recommendations for universal tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccination during pregnancy were released. Our objective was to determine if Tdap, influenza, and pneumococcal vaccine uptake during pregnancy changed after the release of the guidelines, and identify factors associated with receiving the Tdap and influenza vaccine after 2012.

Methods

We conducted a retrospective cohort study on pregnant individuals who initiated prenatal care before 20 weeks’ gestation between 11/2011-11/2012 (“pre-guideline”) and 12/2012-12/2015 (“post-guideline”). Vaccine uptake dates were abstracted from medical records. The pre and post-guideline cohorts were compared to determine if Tdap vaccine uptake and timing improved after the new Tdap guidelines. We additionally examined influenza and pneumococcal vaccine uptake before and after guidelines. Factors associated with receipt of the Tdap and influenza vaccine during pregnancy in the post-guideline cohort were evaluated using multivariable logistic regression models.

Results

Of 2,294 eligible individuals, 1,610 (70.2%) received care in the post-guideline cohort. Among the pre-guideline cohort, 47.4% received Tdap, whereas Tdap uptake increased to 86.1% after the guidelines (p<0.001). Similarly, receiving the Tdap vaccine between the recommended time of 27–36 weeks gestational age improved from 52.5% to 91.8% after the guidelines (p<0.001). Vaccine frequency for influenza improved significantly from 61.2% to 72.0% (p<0.001), while frequency for pneumococcus were low and unchanged. An increased number of prenatal visits was associated with receiving the Tdap and influenza vaccines during pregnancy (respective, aOR 1.09 95% CI 1.05–1.13; aOR 1.50 95% CI 1.17–1.94). Non-Hispanic Black individuals were less likely to receive both the Tdap and influenza vaccines during pregnancy compared to non-Hispanic White individuals (respective, aOR 0.51 95% CI 0.33–0.80; aOR 0.68 95% CI 0.48–0.97).

Conclusions

Receipt and timing of Tdap vaccine improved after implementation of the 2012 ACIP guidelines. Receipt of influenza vaccine uptake also improved during the study period, while uptake of the pneumococcal vaccine remained low. Significant racial disparities exist in receipt of Tdap and influenza vaccine during pregnancy.
Age- and sex-related profiles for macro, macro/micro and microvascular reactivity indexes: Association between indexes and normative data from 2609 healthy subjects (3-85 years)
Authors: Zócalo Yanina , Bia Daniel
Published: July 2021

Vascular reactivity (VR), defined as blood vessels’ capability to actively modify the diameter and flow resistances can be non-invasively assessed analyzing vascular response to forearm occlusion. Several VR indexes can be quantified: (i) ´microvascular´, which consider variables that depend almost exclusively on changes in distal resistances, (ii)´ macrovascular´, that evaluate the changes in brachial artery (BA) diameter, adjusting for blood flow stimulus, and (iii) ´macro/micro´, whose values depend on the micro and macrovascular response without discriminating each one´s contribution. VR indexes could not be associated. Many VR indexes have been used without availability of adequate normative data (reference intervals, RIs). Aims: (1) to evaluate macro, macro/micro and micro VR indexes obtained in a cohort of healthy children, adolescents and adults, (2) to evaluate the association between VR indexes, (3) to determine the need for age and/or sex-specific RIs, and (4) to define RIs for VR indexes. Methods: Ultrasound (B-mode/Doppler) and automatic computerized analysis were used to assess BA diameter, blood flow velocity and distal resistances, at rest and in conditions of decreased and increased blood flow. Macro, macro/micro and micro VR indexes were quantified (n = 3619). RIs-subgroups were defined according to European Reference Values for Arterial Measurements Collaboration Group (n = 1688, 3–84 years) and HUNT3-Fitness Study Group (n = 2609, 3–85 years) criteria. Mean value and standard deviation equations were obtained for VR indexes. The need for age or sex-specific RIs was analyzed. Percentile curves were defined and data were compared with those obtained in other populations. Conclusion: Macro and macro/micro VR indexes showed no association (or it was very weak) with microvascular indexes. Age- and sex-related profiles and RIs for macro, macro/micro and micro VR indexes were defined in a large population of healthy subjects (3–85 y). Equations for mean, standard deviation and percentiles values (year-to-year) were included in text and spreadsheet formats.
Injection time related to intraocular pressure using a CO2 driven preloaded injector: An experimental laboratory study
Authors: Weindler Jan N. , Naujokaitis Tadas , Schickhardt Sonja K. , Khoramnia Ramin , Auffarth Gerd U.
Published: July 2021

Purpose

Experimental study to measure the intraocular lens (IOL) injection time and injection speed at different intraocular pressure (IOP) settings when using the AutonoMe® injector.

Methods

In this experimental study, following phacoemulsification in porcine cadaver eyes, a trocar was inserted at pars plana with a connected infusion and IOPs of 20, 50 and 80 mmHg were generated by altering the infusion height. Twelve CO2 gas-driven injectors were used to implant an IOL via a corneal incision of 2.2 mm. For each IOP setting, the duration of the IOL injection and the injection speed was measured by analyzing a video recording of the procedure.

Results

The mean ±SD injection time (seconds) was 4.47±0.50 at 20 mmHg, 4.98±0.55 at 50 mmHg and 5.47±0.20 at 80 mmHg. The mean ±SD injection speed (millimeters per seconds) was 1.36±0.15 at 20 mmHg, 1.22±0.14 at 50 mmHg and 1.10±0.04 at 80 mmHg.

There was a significant (p<0.05) difference between the 20 and 80 mmHg groups in mean injection duration and injection speed.

Conclusion

The CO2 gas driven injector allows a safe IOL injection even at elevated IOP. Although the implantation time is slightly extended at higher IOPs, this does not seem to be clinically relevant. No IOL damage was observed at these pressure settings.
Renal staffs’ understanding of patients’ experiences of transition from peritoneal dialysis to in-centre haemodialysis and their views on service improvement: A multi-site qualitative study in England and Australia
Authors: Jones Janet E. , Damery Sarah L. , Allen Kerry , Johnson David W. , Lambie Mark , Holvoet Els , Davies Simon J.
Published: July 2021

Introduction

Many studies have explored patients’ experiences of dialysis and other treatments for kidney failure. This is the first qualitative multi-site international study of how staff perceive the process of a patient’s transition from peritoneal dialysis to in-centre haemodialysis. Current literature suggests that transitions are poorly coordinated and may result in increased patient morbidity and mortality. This study aimed to understand staff perspectives of transition and to identify areas where clinical practice could be improved.

Methods

Sixty-one participants (24 UK and 37 Australia), representing a cross-section of kidney care staff, took part in seven focus groups and sixteen interviews. Data were analysed inductively and findings were synthesised across the two countries.

Results

For staff, good clinical practice included: effective communication with patients, well planned care pathways and continuity of care. However, staff felt that how they communicated with patients about the treatment journey could be improved. Staff worried they inadvertently made patients fear haemodialysis when trying to explain to them why going onto peritoneal dialysis first is a good option. Despite staff efforts to make transitions smooth, good continuity of care between modalities was only reported in some of the Australian hospitals where, unlike the UK, patients kept the same consultant. Timely access to an appropriate service, such as a psychologist or social worker, was not always available when staff felt it would be beneficial for the patient. Staff were aware of a disparity in access to kidney care and other healthcare professional services between some patient groups, especially those living in remote areas. This was often put down to the lack of funding and capacity within each hospital.

Conclusions

This research found that continuity of care between modalities was valued by staff but did not always happen. It also highlighted a number of areas for consideration when developing ways to improve care and provide appropriate support to patients as they transition from peritoneal dialysis to in-centre haemodialysis.
Mobile alert app to engage community volunteers to help locate missing persons with dementia
Authors: Neubauer Noelannah , Daum Christine , Miguel-Cruz Antonio , Liu Lili
Published: July 2021

The prevalence of persons living with dementia and at risk of going missing is rising. In this study, we engaged persons living with dementia, care partners, police services, search and rescue organizations, and health and social service providers to develop Community ASAP, a mobile alert system that engages community citizens, as volunteers, to look out for persons with dementia reported missing. We completed three phases of development and evaluation of the usability and functionality of the alert system with stakeholders in three Canadian provinces. In this paper we describe features of the Community ASAP and the findings of these evaluation phases.
Large-scale survey of prion protein genetic variability in scrapie disease-free goats from the United States
Authors: Zeineldin Mohamed , Lehman Kimberly , Urie Natalie , Branan Matthew , Wiedenheft Alyson , Marshall Katherine , Robbe-Austerman Suelee , Thacker Tyler
Published: July 2021

Scrapie is a slowly progressive neurodegenerative disease of small ruminants caused by an accumulation of an abnormal isoform of prion protein in the central nervous system. Polymorphisms of the prion protein gene (PRNP) strongly modulate scrapie resistance and incubation period in goats. The aim of this study was to identify PRNP genetic variability in goats across the United States. Blood from a total of 6,029 apparent scrapie disease-free goats from 654 operations and 19 breeds were analyzed. Sequencing of PRNP revealed 26 genotypes with different rates based on eight codons. The GG127, RR154, and QQ222 genotypes were predominant and showed a remarkably high rate across all goats. The QK222 and NS146 genotypes, known to be protective against scrapie, were found in 0.6% [with 95% CI = (0.3, 1.2)] and 22.0% [95% CI = (19.1, 25.2)] of goats, respectively. The QK222 genotype was found in 23.1% of Oberhasli goats tested, with 95%CI = (3.9, 68.7)] and 22.0% of Toggenburg goats tested with 95%CI = (9.7, 42.5)], while NS146 was found in 65.5% of Savannah goats tested, with 95%CI = (30.8, 89.9), 36.7% of Boer goats tested, with 95%CI = (33.1, 40.4), 36.3% of Nubian goats tested, with 95%CI = (27.0, 46.7)], and 35.6% of LaMancha goats tested, with 95%CI = (22.8, 50.8%). The MM142 and IM142 genotypes were found more frequently in goats on dairy operations, while the HR143, NS146, and ND146 genotypes were found more frequently in goats on meat operations. Goats in the east region had a higher percentage of goats with RH154, RQ211, and QK222 genotypes than goats in the west region. The results of this study showed high genetic variability of PRNP among the U.S. goat population, with differences by location and breed, and may serve as a rationale for development of goat breeding programs at the national level to mitigate the risk of scrapie.
High-Performance Deep learning to Detection and Tracking Tomato Plant Leaf Predict Disease and Expert Systems
Authors: Jasim Yaser AbdulAali
Published: July 2021

Nowadays, technology and computer science are rapidly developing many tools and algorithms, especially in the field of artificial intelligence.  Machine learning is involved in the development of new methodologies and models that have become a novel machine learning area of applications for artificial intelligence. In addition to the architectures of conventional neural network methodologies, deep learning refers to the use of artificial neural network architectures which include multiple processing layers.

In this paper, models of the Convolutional neural network were designed to detect (diagnose) plant disorders by applying samples of healthy and unhealthy plant images analyzed by means of methods of deep learning. The models were trained using an open data set containing (18,000) images of ten different plants, including healthy plants. Several model architectures have been trained to achieve the best performance of (97 percent) when the respectively [plant, disease] paired are detected. This is a very useful information or early warning technique and a method that can be further improved with the substantially high-performance rate to support an automated plant disease detection system to work in actual farm conditions.
Formación del profesorado y tecnologías de la información y la comunicación. Renovación y convergencia para la educación 2.0 en el “(ciber)Espacio Europeo de Educación Superior”
Authors: Gutiérrez Martín Alfonso
Published: July 2021

En este artículo se relacionan tres temas de gran actualidad y enorme interés educativo: la construcción del Espacio Europeo de Educación Superior (convergencia universitaria europea); la convergencia tecnológica y los cambios significativos que dan lugar a la Web 2.0, y la formación del profesorado en TIC (Tecnologías de la Información y la Comunicación). La innovación permanente en la formación del profesorado, sobre todo la específica en medios y TIC, resulta imprescindible en la “cultura de la convergencia”. Es imprescin-dible tanto para la construcción de EEES, como para la creación de ciudadanos partici-pativos en el espacio o ciberespacio que estén llamados a transformar. Proponemos nuevas competencias para la “realfabetización digital” del profesorado, para una integración curricular de las TIC como recursos, contenidos y entornos de aprendizaje que contribuya a educar para el progreso global, la realización personal y la integración social y laboral.
Actitudes, satisfacción, rendimiento académico y comunicación online en procesos de formación universitaria en Blended Learning
Authors: Cabero Almenara Julio , Llorente Cejudo Mª del Carmen
Published: July 2021

El estudio tiene como propósito principal conocer las actitudes, la satisfacción, el rendimiento académico, y los usos de las herramientas de comunicación online en los alumnos que participan en procesos de formación Blended Learning. Una metodología cuantitativa y cualitativa de recogida y análisis de datos (cuestionarios, grupos de discusión y análisis de la comunicación online) fue utilizada para comprender cómo se desarrolla este nuevo proceso de formación en 334 estudiantes universitarios. Éstos mostraron tener una actitud positiva hacia Internet, y la modalidad se presentó como satisfactoria para los alumnos, y aumentó también su rendimiento académico. Los resultados revelaron que, los usos que hacen los alumnos de los foros de discusión estaban destinados, fundamentalmente, hacia aspectos sociales e informales.
Effectiveness of E-learning Environments in Developing Skills for Designing E-tivities Based on Gamification for Teachers of Technology in Gaza
Authors: Firwana Akram , Abu Shouqer Mohammed , Aqel Magdy
Published: July 2021

The Corona Global Pandemic created challenges for teachers and students in using E-learning tools in the teaching and learning process. Thus, training teachers to use these tools was extremely crucial. The current study examined the effectiveness of E-learning environments on developing the skills to design E-tivities based on Gamification for Gaza technology teachers. The researchers followed the quasi-experimental approach for two randomly selected experimental groups. The first experimental group was taught via E-learning social environment Edmodo, while the second experimental group was taught via the personal E-learning environment Wordpress. Every group consists of 30 teachers teaching Information Technology for secondary students. The group equivalence was adjusted before the experiment in designing E-tivities skills based on gamification. To collect data, the researchers prepared an observation card of the skills for designing E-tivities based on gamification. The observation card dealt with the design tools and their sub-indicators, and it was applied before and after the intervention phase. The results showed that there were no statistically significant differences at the level (? ? 0.05) between the mean of the teachers’ scores in the experimental social environment group Edmodo, and the experimental personal learning environment group Wordpress in the post-application of the observation  card for designing E-tivities skills based on gamification. Additionally, the findings revealed a great effectiveness of E-learning social environment Edmodo and the personal E-learning environment Wordpress on developing skills for designing E-tivities based on gamification. In the light of these results, it is recommended that social and personal E-learning environments should be employed in developing the skills of teachers and improving their experiences. This is helpful in organizing and displaying information in additon to facilitating communication between the components of the educational process and the benefit of using these environments in training teachers under the Global pandemic, Coronavirus, COVID-19.
La sociología de la educación desde la pedagogía crítica
Authors: Camdepadrós Roger , Pulido Cristina
Published: July 2021

Una de las tareas principales de la sociología de la educación es identificarqué teorías generan éxito educativo y cuáles conducen al fracaso escolar. Sólo identificandoestos elementos la sociología de la educación podrá cumplir su utilidad social. Eneste artículo analizamos dos perspectivas teóricas; la perspectiva basada en el modelo dela reproducción y la perspectiva dual vinculada a las aportaciones de la pedagogía crítica.De ambas se analiza qué prácticas educativas se generan a partir de sus principios ysu incidencia en la realidad social.
El papel de la clase trabajadora (otras mujeres) en la educación crítica
Authors: Merrill Barbara
Published: July 2021

Este artículo aborda el papel de (otras) mujeres de clase trabajadora que retornana la educación a través de la universidad y de la participación y educación comunitarias.El análisis de las experiencias educativas se hace a través de las voces de mujerestrabajadoras, empleando enfoques biográficos de orientación feminista. Las historiasponen de manifiesto la importancia de las desigualdades de clase y de género. Las biografíasresaltan la capacidad que tiene la educación como experiencia transformadora,mientras éstas reflexionan críticamente sobre sus experiencias vitales. Teóricamente separte del feminismo y la llamada ´educación radical de las mujeres`, y se resalta la críticadel feminismo académico defendiendo una perspectiva más dialógica. Aunque escierto que las universidades ofrecen a las mujeres un espacio de transformación, resultaevidente que el currículo universitario debería apoyarse de una manera más explícita yprofunda en las experiencias y los conocimientos de las mujeres.
Redes comunitarias de banda ancha: una contribución para el desarrollo regional en Portugal
Authors: Nunes Flávio Paulo Jorge
Published: July 2021

El acceso a Internet por banda ancha constituye una potencialidad cada vez más relevante en el dominio del desarrollo regional, con todo la privatización y la liberalización del sector de las telecomunicaciones y la mera aplicación de las reglas del mercado no han conseguido asegurar una repartición geográfica equitativa del acceso a la banda ancha. Ante la constatación de esta tendencia se ha requerido financiación pública para la creación de las infraestructuras necesarias para generalizar el acceso a esta red, sobre todo en las áreas rurales menos pobladas. Este estudio tiene como objetivo evaluar la respuesta dada en Portugal para complementar la acción de las operadoras privadas de telecomunicaciones, con la creación de redes comunitarias de banda ancha. Actualmente está en curso la implementación de cuatro proyectos de redes comunitarias en Portugal, que pretenden viabilizar el acceso a aplicaciones telemáticas más innovadoras, las cuales constituyen hoy en día una condición necesaria para el éxito de muchos de los proyectos más innovadores de desarrollo regional y local.
Development of lymphocyte subpopulations in local breed chickens
Authors: Al-Ogaili Adil Sabr , Hameed Samer Sadeq
Published: July 2021

Background and Aim: Local breeds of chicken are known to have relatively higher disease resistance to many endemic diseases and diseases that are highly virulent in commercial chickens. This study aimed to address the lymphocyte subpopulations in three constitutive immune system organs (thymus, bursa of Fabricius, and spleen) in 30, 8-week-old, male local breed chickens. Materials and Methods: The T (CD3+) and B lymphocytes (Bu-1+) were identified through one-color, direct immunofluorescent staining of the thymus, bursa, and spleen lymphocytes. Likewise, two-color, direct immunofluorescent staining was performed to identify the CD4- and/or CD8-defined T lymphocytes. The proportions of T and B lymphocytes and CD4- and/or CD8 defined chicken lymphocyte subsets in lymphoid suspensions prepared from the thymus, bursa, and spleen were determined by flow cytometry. Results: CD3+ cells, particularly those positive for CD4+CD8–, were dominant in the thymus, whereas cells expressing the Bu-1 marker were predominant in the bursa of Fabricius. The proportion of T and B cells was almost equal in the spleen, with more cells expressing the CD4–CD8+ marker in the red pulp. Conclusion: These findings indicate that local breeds of chicken could serve as a reliable model for studying the immune system of commercial light chicken breeds, due to the similarity in the presence and the distribution of the immune cells.
External risk factors associated with language disorders in children
Authors: Wangke Lydia , Victory Wenny , Joey Gregory , Rampengan Novie Homenta , Lestari Hesti
Published: July 2021

Background Children with language delay have deficits in the ability to learn and use language, either expressive and/or receptive despite otherwise normal development. Language delay could be influenced by either internal factors (within the child) and external factors (from the environment). Timely identification and modification of these risk factors can allow early intervention to reduce child disability and are associated with better long-term outcomes.

Objective To identify possible risk factors related to language delay in children, such as bilingualism, socioeconomic status, maternal and caregiver education level, use of digital media, absence of story reading sessions, breastfeeding patterns, siblings, parenting methods, and maternal occupation.

Methods This observational, analytic study included 102 children aged 24-36 months from four daycare centers in Manado, North Sulawesi, selected by cluster random sampling. Parents were interviewed to gather demographic information of child age, gender, presence of older siblings, maternal occupation, socioeconomic status, maternal/caregiver educational level, use of digital media, absence of story reading sessions, breastfeeding patterns, parenting methods, and bilingual environment. Children’s language development was assessed by the Capute Scales.

Results Multivariate analysis revealed 2 factors significantly associated with increased risk of language delay; namely absence of storybook reading (OR=0.16; 95%CI 0.03 to 0.72; P=0.017) and bilingualism (OR=12.58; 95%CI 1.57 to 100.81; P=0.017).

Conclusion Story reading sessions is associated with decreased risk of language delay, shile bilingualism is associatd with increased risk of language delay.
Peran Suplementasi Seng dalam Menurunkan Intensitas Mukositis Oral Akibat Kemoterapi Fase Konsolidasi pada Anak dengan Leukemia Limfoblastik Akut
Authors: Arysanti Manik Trisna , Ariawati Ketut , Subanada Ida bagus
Published: July 2021

Latar belakang. Mukositis oral merupakan salah satu efek samping kemoterapi yang dapat berdampak buruk terhadap pengobatan kanker. Mikronutrient seng diketahui dapat mempertahankan integritas mukosa oral.Tujuan. Mengetahui efek suplementasi seng dalam menurunkan intesitas mukositis oral akibat kemoterapi.Metode. Uji klinis acak terkontrol tersamar ganda dilakukan pada 40 pasien anak dengan leukemia limfoblastik akut (LLA) yang menjalani kemoterapi fase konsolidasi, dengan membandingkan kejadian dan derajat mukositis oral pada kelompok yang mendapat suplementasi seng atau plasebo. Derajat mukositis oral dievaluasi menggunakan NCI-CTAE versi 3.0. Hasil. Kejadian mukositis oral lebih rendah pada kelompok seng (40%) dibandingkan plasebo (55%), tetapi perbedaan tersebut tidak signifikan (p=0,342). Derajat keparahan mukositis oral lebih rendah secara signifikan pada kelompok seng dibandingkan plasebo (p=0,024; RR 0,306; IK95%;0,089 sampai 1,048). Analisis kesintasan Kaplan-Meier menunjukkan waktu munculnya mukositis oral beserta derajat keparahannya pada kedua kelompok hampir sama sampai minggu kedua, kemudian mulai menurun sampai akhir pengamatan pada kelompok seng. Analisis multivariat Cox Regression menunjukkan variabel akhir sebagai prediktor kuat terhadap kejadian mukositis adalah usia, status gizi, dan kadar seng.Kesimpulan. Pemberian suplementasi seng tidak dapat menurunkan kejadian mukositis oral akibat kemoterapi pada pasien anak dengan LLA, tetapi dapat menurunkan derajat keparahannya bila dibandingkan dengan plasebo.
Actualization of song and poetic text features in the texts of “rock” and “pop” genres.
Authors: Baklanova Evgeniya , Kolesov Igor
Published: July 2021

In this article a song, or more specifically, a song-and-poetry text, is presented as a literary musical piece of art displaying a number of distinctive text features. The authors define criteria for distinguishing various text manifestations. As the criteria of the text as a verbal speech product, the authors consider such main features of the text as its semiotic, structural, semantic, functional and communicative characteristics. Song-and-poetry texts of various genres, such as “rock” and “pop” are discussed in the article. They are analyzed in accord with the main features of the text. In the process of analysis, both general and distinctive features of texts of contrasting genres are revealed. By analyzing the samples of the texts belonging to rock and pop, the authors claim that while determining the text type or genre, one criterion is not enough, owing to the versatility of a text. The authors conclude that it is the combination of features of song-and-poetry texts revealed in the analysis of the aspects considered in the article that can serve the instrument for differentiating between song-and-poetry texts of various genres.
Statins and Liver Cancer in Cirrhosis: The Most Relevant Questions Are Still Unanswered
Authors: Moctezuma-Velazquez Carlos , Abraldes Juan G.
Published: July 2021

Several observational studies have shown an association between statin use and lower incidence of liver cancer. However, several potential biases limit a causal interpretation that could lead to a recommendation of statin prescription to patients with cirrhosis in the absence of a cardiovascular indication. Ongoing randomized trials will soon provide a clearer picture on the efficacy and safety of statins for preventing liver cancer and other complications of cirrhosis.
Estudio Transversal: Conducta de agresión en estudiantes de quinto año de secundaria de cuatro instituciones educativas periféricas de Lima, Perú
Authors: Pacheco Salazar María de Lourdes , Dámaso Flores Jesús , Ordóñez Ordóñez Miriam Carlota , Salazar Montesdeoca Diego Mauricio
Published: July 2021

BACKGROUND: Aggression among schoolchildren is a growing problem, affecting their educational, social and cultural well-being. In this context, aggression has become an aim of study for Social Sciences, from various approaches. The intensity of this problem negatively impacts on children and adolescents lives. Numerous studies report that events of violence and/or aggression in schools can generate physical and emotional damage to schoolchildren, learning difficulties due to post-trau-matic stress disorder, demotivation, absenteeism and school dropout. The aim of this study was to establish the level of aggression in fifth-year high school students from high schools in Lima, Peru. METHODS: Descriptive, cross-sectional, quantitative exploratory study. The Buss and Perry, Aggres-sion Questionnaire was applied and adapted to the context. The content validity was obtained with Aiken’s V coefficient (0.80) for each item and dimension. The Kolmogorov- Smirnov normality test was used for data analysis. Data is presented in charts, with frequencies and percentages. RESULTS: The study was applied to a sample of 274 adolescents, aged 15 to 18 years. High levels of aggression were found in the students (54.8%; High aggression level: 38.6%, very high aggression level: 16.2%), with a predominance in the male group (43%), compared to 34% in women. Regarding the aggression dimensions, we found high levels, in verbal aggression (40%), followed by physical aggression and hostility (38%) and finally anger (37%). CONCLUSION: After data processing, high levels of aggression were found among fifth-year high schools students from peripheral areas of Lima. Regarding gender, a predominance of high-level aggression was found in males over females. About aggression dimensions, we found a high level of verbal aggression, followed by physical aggression and hostility, finally by anger. KEYWORDS: BEHAVIOR, AGGRESSION, TEENAGER, ANGER, HOSTILIT
A propósito de un caso: Resolución quirúrgica en dos tiempos de Pentalogía de Cantrell
Authors: Muñoz Mora Andrea Karina , Ordóñez Velecela María Soledad , Marcano Sanz Luis Enrique , Endis Miranda Miurkys
Published: July 2021

BACKGROUND: Cantrell’s pentalogy includes the presence of five birth defects that represent a great challenge for surgeons. Abnormalities of the heart, pericardium, diaphragm, sternumand anterior abdominal wall are the main findings. Its incidence is low, however, it is essential to identify Cantrell´s pentalogy timely to adopt an adequate therapy for all specific defects, since it has high mortality. CASE REPORT: The patient was a full- term male newborn, with a history of abdominal wall defect compatible with an omphalocele detected by prenatal ultrasound. After the caesarean section, the abdominal wall defect was notable, the left liver lobe, intestines and heart emerged through it, the sternum also had a low fissure. The echocardiogram revealed a permeable oval foramen, mild tricuspid regurgitation, and severe pulmonary hypertension. EVOLUTION: Immediate surgical management was decided. Silo was placed, with progressive closure of the midline in 7 days. During the second surgical procedure, the diaphragmatic and pericardial defect was corrected with a bovine pericardial prosthesis. Despite the adequate evolution after surgery, at day 28 he presented with sudden cyanosis and didn’t respond to cardiopulmonary resuscitation and died. CONCLUSIONS: Cantrell’s Pentalogy is a rare disease, with peculiar clinical, anatomical and embryological characteristics, it represents a unique challenge for surgeons. Early diagnosis, as well as follow-up during pregnancy, planning a cesarean section in a high-level center and immediate surgical approach with a multidisciplinary team, are the key components in the management of patients with Cantrell’s Pentalogy. KEY WORDS: PENTALOGY OF CANTRELL, ECTOPIA CORDIS, UMBILICAL HERNIA. CONGENITAL.
Reflexões na Ortodontia
Authors: Almeida Marcio Rodrigues
Published: July 2021

Neste editorial, faremos uma reflexão acerca do conteúdo desta edição, que está incrível e recheada de informações relevantes da nossa querida Ortodontia. Acredito que o segredo para aprender Ortodontia é colocar em prática tudo aquilo que foi ensinado na pós-graduação ou angariado por meio da leitura de livros ou artigos ao longo do tempo. Temos que ser eternos estudantes, e o tempo dedicado a estudar é um tempo ganho para aprender e nos fazer crescer, tanto como pessoa quanto como profissional.
Máyra Reis Seixas
Authors: Artese Flávia , Menezes Luciane , Schroeder Marco , Brandão Roberto , Câmara Carlos Alexandre
Published: July 2021

Pode-se dizer, com toda a segurança, que a Dra. Máyra Seixas é um daqueles raros talentos, difíceis de se encontrar em qualquer profissão. A Ortodontia foi o lugar que ela escolheu, especialmente, para disponibilizar o seu virtuosismo, figurando como uma clínica habilidosa, exímia escritora e professora carismática. Essa baiana de humor refinado, misturado com posicionamentos firmes, agrega atributos suficientes para se tornar uma pessoa querida por muitos e respeitada por todos. Faz parte de uma geração de profissionais que valorizam a Ortodontia “raiz”, na qual as novidades podem e devem ser bem-vindas, desde que apresentem evidências clínicas e científicas consistentes e vantajosas, que justifiquem possíveis mudanças.
Movimentação dentária com alinhadores
Authors: Souza Isabela Fátima Araújo , Martins Renato Parsekian
Published: July 2021

INTRODUÇÃO: Durante a montagem de um setup virtual com o intuito de produzir alinhadores, pode ser sedutor movimentar um dente de corpo; no entanto, tais setups serão imprevisíveis. OBJETIVO: Mostrar a aplicação de conceitos básicos de biomecânica no tratamento com alinhadores em um caso de complexidade média. CONCLUSÃO: A utilização de conceitos biomecânicos formais possibilitou a correção da mordida cruzada da paciente sem a utilização de qualquer acessório auxiliar.
Extração dos primeiros molares no tratamento de paciente hiperdivergente e com protrusão dentária
Authors: Valarelli Fabrício , Pinto Rayane Oliveira , Higa Rodrigo Hitoshi , Raveli Dirceu Barnabé , Valarelli Danilo Pinelli
Published: July 2021

INTRODUÇÃO: A extração de molares permanentes com finalidade ortodôntica é considerada atípica. Contudo, pode ser indicada em casos de comprometimento restaurador, endodôntico ou periodontal de tais dentes. OBJETIVO: O objetivo do presente trabalho é relatar o tratamento de uma paciente com 34 anos de idade, sexo feminino, hiperdivergente, que apresentava biprotrusão dentária, ausência de selamento labial e perfil convexo. O tratamento foi realizado com extração de quatro primeiros molares, justificada pela necessidade de espaço para retração dos incisivos e melhora do perfil facial, além de apresentar restaurações extensas nos primeiros molares permanentes. Após as extrações dentárias, a mecânica de fechamento de espaços foi realizada sem ancoragem. RESULTADOS: O tratamento ortodôntico proporcionou uma melhora significativa na face, amenizando a convexidade do perfil e favorecendo o selamento labial. A relação de Classe I foi mantida, conservando os pré-molares e possibilitando a erupção dos terceiros molares. O caso foi finalizado com excelente oclusão estática e funcional. CONCLUSÃO: A extração de molares permanentes, quando bem indicada, pode constituir uma excelente opção para o tratamento de pacientes hiperdivergentes com biprotrusão dentária.
A importância da guia anterior imediata: parte 2
Authors: Janson Marcos
Published: July 2021

INTRODUÇÃO: A guia anterior imediata é um dos objetivos mais importantes da Ortodontia, relacionado com a oclusão funcional, estabilidade vertical do tratamento e estética labial. OBJETIVO: Na parte 1 desse artigo, exploramos a importância da guia anterior na estabilidade em longo prazo dos casos ortodônticos. Daremos continuidade ao assunto, mostrando, agora, a sua importância na posição dos lábios e, consequentemente, na estética facial.
Estratégias de estagiamento e o uso de terapia auxiliar no tratamento ortodôntico com o Invisalign® associado à extração dentária
Authors: Almada Rodrigo de Oliveira
Published: July 2021

INTRODUÇÃO: O uso dos alinhadores ortodônticos tem apresentado um aumento significativo na prática clínica, sendo utilizado, inclusive, em casos complexos, exigindo do ortodontista um maior conhecimento biomecânico do sistema, principalmente no que tange ao estagiamento da movimentação e ao uso de terapia auxiliar durante o tratamento. OBJETIVO: Sendo assim, o presente artigo tem como objetivo relatar o tratamento para a correção da Classe II dentária associado a extrações de primeiros molares superiores, utilizando-se o sistema Invisalign®, evidenciando as dificuldades que podem ocorrer durante a mecânica e suas possíveis soluções. CONCLUSÃO: O tratamento ortodôntico com alinhadores pode trazer excelentes resultados, inclusive em casos complexos, desde que o ortodontista tenha experiência na sua biomecânica e saiba lidar com possíveis dificuldades durante o tratamento e, dessa forma, estabelecer uma correta conduta clínica no seu manejo.
Human Resource Management Model for BPO Companies
Authors: Duque Ceballos José Luis , Zapata Domínguez Álvaro , García Solarte Mónica , Murillo Vargas Guillermo
Published: July 2021

Este artículo tiene como objetivo presentar un modelo de gestión humana que se adapta a las necesidades de las organizaciones de BPO. La metodología utilizada en el proceso investigativo fue de enfoque cualitativo con la aplicación de entrevistas y revisión documental para la recolección de información relativa a las necesidades de las organizaciones de BPO, presentando como principal resultado un modelo que permite identificar los insumos, procesos y salidas que debería tener el área de gestión humana para generar estrategias y actividades pertinentes y oportunas a este tipo de organizaciones. En términos de aporte, dicho modelo le permite al lector entender la dinámica y características de los procesos de gestión humana en organizaciones cuyos objetivos y aspectos estratégicos son distintos a las organizaciones tradicionales, a la vez que identifica aquellos procesos más relevantes para el alcance de dichos fines.
The Impact of COVID-19 Pandemic on Higher Education and Research: Learning from Experience and the Way Forward
Authors: Abdul Ghani Ahmad Bashawir , Mahat Nor Idayu , Omar Mohd Faizal , Bakar Shahbani Abu
Published: July 2021

The COVID-19 pandemic took its toll on many countries in early 2020 after the first case was reported in China at the end of 2019. Malaysia was not spared either and the Government was forced to take a bold yet drastic measure in implementing the Movement Control Order (MCO) in earnest on 18 March 2020. The measure, akin to a lockdown, practically forced all forms of socio-economics and socio-educational activities to come to an abrupt stop. Schools, institutions of higher learning and training centers were directed to close its doors to students. Universiti Utara Malaysia (UUM) had to abruptly implement contingency plans in the wake of the negative impact brought about by the pandemic. Almost all academic activities had to be reorganized when majority of the students opted to return to the safety of their home environment, and the staff were required to work from home in compliant with the MCO. This development necessitated the University to introduce the remote learning mode in place of the traditional face to face learning and teaching (T&L). Various other strategies and measures were also introduced by the University which required reprioritization of tasks and determining possible risks that could impede normal daily operations. UUM opted for a holistic approach to address the impending concerns and to ensure the continuity of the education process and to address the wellbeing of its staff who are forced to work from home.
Sustainable Universities _The GreenMetric Tool As a Strategic Driver in HEIs Considering Different Realities
Authors: Vitoreli Marinez Cristina , Guarnetti Rodrigo Luiz , Mariano Enzo Barbério
Published: July 2021

In this work the considered concept of sustainability explores the relationships between economic development, environmental quality as well as social. Delineated by the UN in 1972, since then the subject has taken on great proportions, mainly due to its imminent urgency. In 2015 the theme was part of the UN's Sustainable Development Goals, making up the Agenda 2030. Recently, Higher Education Institutions have been compelled to offer their contributions, given their role in human formation. Considering GreenMetric's relevance since the beginning of its activities, its dimensions and indicators have offered relevant directions on the path of Sustainable Higher Education Institutions. Thus, the present work demonstrated, through the case study, how the dimensions and indicators proposed by GreenMetric could form part as an important strategic driver in the path of a Brazilian Higher Education Institution - Academic Center, located in the countryside of São Paulo State. Its registration at GreenMetric in 2019 allowed the same formulations of short, medium and long term strategies.