bluuebunny/crossref_metadata_2025 huggingface dataset:
Bacillus coagulans TL3 Inhibits LPS-Induced Caecum Damage in Rat by Regulating the TLR4/MyD88/NF-κB and Nrf2 Signal Pathways and Modulating Intestinal Microflora
Authors: Wang Yan , Lin Jiaxi , Cheng Ziyang , Wang Tiancheng , Chen Jia , Long Miao
Published: February 2022

Background. Bacillus coagulans has been widely used in food and feed additives, which can effectively inhibit the growth of harmful bacteria, improve intestinal microecological environment, promote intestinal development, and enhance intestinal function, but its probiotic mechanism is not completely clear. Aim. The aim of this study is to discuss the effect and mechanism of Bacillus coagulans TL3 on oxidative stress and inflammatory injury of cecum induced by LPS. Method. The Wistar rats were randomly divided into four groups, each containing 7 animals. Two groups were fed with basic diet (the LPS and control, or CON, groups). The remaining groups were fed with basic diet and either a intragastric administration high or low dose of B. coagulans, forming the HBC and LBC groups, respectively. The rats were fed normally for two weeks. On the 15th day, those in the LPS, HBC, and LBC groups were injected intraperitoneally with LPS—the rats in the CON group were injected intraperitoneally with physiological saline. After 4 hours, all the rats were anesthetized and sacrificed by cervical dislocation, allowing samples to be collected and labeled. The inflammatory and antioxidant cytokine changes of the cecum were measured, and the pathological changes of the cecum were observed, determining the cecal antioxidant, inflammation, and changes in tight junction proteins and analysis of intestinal flora. Result. The results show that LPS induces oxidative damage in the cecal tissues of rats and the occurrence of inflammation could also be detected in the serum. The Western blot results detected changes in the NF-κB- and Nrf2-related signaling pathways and TJ-related protein levels. Compared with the LPS group, the HBC group showed significantly downregulated levels of expression of Nrf2, NQO1, HO-1, GPX, and GCLC. The expression of TLR4, MYD88, NF-κB, IL-6, TNFα, and IL-1β was also significantly downregulated, while the expression of other proteins (ZO-1, occludin, and claudin-1) increased significantly. Bacillus coagulans TL3 was also found to increase the relative abundance of the beneficial bacterium Akkermansia muciniphila in the intestines. There is also a significant reduction in the number of harmful bacteria Escherichia coli and Shigella (Enterobacteriaceae). Conclusion. Bacillus coagulans TL3 regulates the TLR4/MyD88/NF-κB and Nrf2 signaling pathways in the cecal tissue of rats, protects the intestine from inflammation and oxidative damage caused by LPS, and inhibits the reproduction of harmful bacteria and promotes beneficial effects by regulating the intestinal flora bacteria grow, thereby enhancing intestinal immunity.
Acute Disseminated Encephalomyelitis Presenting as Bilateral Ptosis in a Sri Lankan Child
Authors: Kumarasiri Ishara , Samararathna Ruwan , Sandakelum Udara , Muthukumarana Oshanie , Balasubramaniam Reha , Mettananda Sachith
Published: February 2022

Introduction. Acute disseminated encephalomyelitis is a rare inflammatory demyelinating disease characterized by acute onset polyfocal neurological deficits associated with encephalopathy. It commonly presents with fever, meningism, seizures, ataxia, motor deficits, and bladder dysfunction. Although cranial neuropathies, including optic neuritis and facial nerve palsies, have previously been reported, children presenting with bilateral ptosis is extremely rare. Here, we report a 3-year-old child with acute disseminated encephalomyelitis presenting with acute onset bilateral ptosis due to involvement of the single central levator subnucleus of the oculomotor nerve. Case Presentation. A 3-year-old Sri Lankan boy presented with drooping of the upper eyelids for three days and unsteady gait for two days. He did not have seizures, blurring of vision, limb weakness, swallowing or breathing difficulties, or bladder dysfunction. On examination, he had bilateral ptosis, gait ataxia, and dysmetria. His vision, eye movements, and examination of other cranial nerves were normal. MRI brain revealed high signal intensities involving the subcortical white matter of parietal and occipital lobes, midbrain in the area of single central levator subnucleus of the oculomotor nerve, cerebellar vermis, and right cerebellar hemisphere. Based on the clinical features suggesting polyfocal neurological involvement of the midbrain and cerebellum and characteristic MRI findings, the diagnosis of acute disseminated encephalomyelitis was made. He responded well and rapidly to high-dose intravenous methylprednisolone and showed a complete clinical and radiological recovery. Conclusion. This case report describes a rare presentation of acute disseminated encephalomyelitis, bilateral ptosis due to involvement of the single central levator subnucleus of the oculomotor nerve. It highlights that the presenting manifestations of acute disseminated encephalomyelitis can be subtle and vary; however, timely diagnosis and treatment result in complete recovery.
Changes of Cell Adhesion Molecules and T Cell Subset Populations in Acute Myeloid Leukemia Patients Undergoing Intravenous Administration of Cytarabine Supplemented with Idarubicin
Authors: Piao Jinhua , Wang Didi , Pei Siying , Ge Tangdong , Li Jing , Zhang Pengxia
Published: February 2022

Objective. The present study aimed at investigating the efficacy and safety of intravenous administration of cytarabine supplemented with idarubicin in treating acute myeloid leukemia (AML) patients undergoing first attack and its effects on serum levels of cell adhesion molecules, cytokines in response to inflammation, and T cell subset populations in acute myeloid leukemia (AML) patients undergoing first attack. Methods. A total of 88 AML patients eligible for inclusion and exclusion criteria participated in the study and were randomly assigned into the control group (n = 44) in which the patients received intravenous administration of cytarabine and daunorubicin and the study group (n = 44) in which the patients received intravenous administration of cytarabine and idarubicin. Clinical response, incidence of adverse reactions, and quality of life 3 months after therapy were evaluated. Soluble intercellular adhesion molecule-1 (sICAM-1), soluble vascular cell adhesion molecule-1 (sVCAM-1), IL-10, and IL-35 were measured by ELISA methods. Phenotypic characteristics of T cell subsets including CD4+, CD8+, CD4+IL-10 Tregs, and CD4+CD25+CD127−Foxp3+ Tregs were analyzed by flow cytometry. Results. The clinical response rate of the study group was better than that of the control group (65.91% vs. 45.45%) (

P
<
0.05

). After treatment, the study group revealed significantly lower levels of sICAM-1, sVCAM-1, IL-10, and IL-35, a lower proportion of Tregs, a higher rate of CD4+/CD8+ T cells, along with increased scores of the Karnofsky Performance Scale (KPS) compared with the control group (

P
<
0.05

). The incidence rate of adverse reactions in the study group was lower than that in the control group (34.09% vs. 61.36%) (

P
<
0.05

). Conclusion. These findings demonstrate that intravenous administration of cytarabine supplemented with idarubicin can improve the immune function and quality of life of AML patients, and this combination drug therapy is effective and safe for AML.
A Crowdsourcing Information Obtaining Scheme Aiming at Senior Netizens Based on Blockchain
Authors: Qin Yanlin , Zhou Xueguang , Wei Guoheng
Published: February 2022

Senior netizens play a unique role in crowdsourcing information obtaining, but the traditional crowdsourcing information obtaining scheme based on intermediary platform cannot satisfy the senior netizens’ strong reliability on anonymity. Malicious intermediary platform may leak out the privacy information of both parties. Data stored in intermediary platform may be intercepted, tampered, and fraudulently used by attackers, so smooth crowdsourcing information transactions cannot be ensured. In order to achieve secure and reliable crowdsourcing information obtaining, blockchain technology with decentralization and nontampering was used to propose a crowdsourcing information obtaining scheme, which is independent on intermediary platform. During processes of requirements releasing, information submitting, and rewarding, privacy protection techniques were used to preserve the anonymity of participants and confidentiality of data. Compared with the existing protocols, the proposed scheme has obvious advantages in privacy protection.
Systematic Screening for SARS-CoV-2 to Detect Asymptomatic Infections: An Epitome of Taiwan’s Outbreak
Authors: Cheng Chih-Chien , Liu Chia-Chen , Yen Ju-Chuan , Chiu Ting-Fang , Liu Yi-Ning , Hsueh Thomas Y. , Hsiao Sheng-Huang
Published: February 2022

Background. Increased studies have revealed that asymptomatic carriers substantially impact the epidemic and that asymptomatic transmission is very common. Therefore, the asymptomatic transmission threat to the spread of the pandemic should not be neglected. Methods. The local outbreak in Taiwan, especially in Taipei City, is unprecedented and paramount and has claimed hundreds of lives, tens of thousands of cases, and enormous economic costs. As care providers and gatekeepers of infectious diseases, Taipei City Hospital has to perform regular polymerase chain reaction (PCR) results of admitted patients and healthcare workers (HCWs) to achieve these goals. Results. In this study, the results revealed a low positive rate of less than 1%, but the asymptomatic proportions could range from 42% to 46%, which bolsters that systematic screening was effective in controlling coronavirus disease-19 (COVID-19) of Novel Coronavirus or Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) and might be an exemplar to other similar scenarios. Universal screening of admitted patients may be important and necessary, especially in asymptomatic patients. Conclusions. Regular screening for healthcare providers is also important during this pandemic, and it is recommended that admitted patients and healthcare providers undergo systemic PCR testing.
State of the Art in Quorum-Based Sleep/Wakeup Scheduling MAC Protocols for Ad Hoc and Wireless Sensor Networks
Authors: Alzahrani Eman , Bouabdallah Fatma , Almisbahi Hind
Published: February 2022

In energy-constrained networks, designing an energy-efficient MAC protocol is crucial since the MAC protocol controls the access of the nodes to the shared wireless medium. Indeed, an efficient MAC protocol should reduce or even mitigate the consumption of the main sources of energy wastage, namely, overhearing, collision, and idle listening, and hence the network lifetime will be improved. One of the most efficient solutions is designing a MAC protocol that utilizes the quorum concept to increase energy efficiency by reducing idle listening and overhearing. Researchers have proposed several quorum-based MAC protocols to conserve energy. This paper presents a detailed overview and classification of several existing quorum-based sleep/wakeup scheduling MAC protocols. We classify these quorum-based MAC protocols into homogeneous and heterogeneous based on their quorum system characteristics. Moreover, we further classify these protocols according to the guaranteed intersection between any two quorums into fixed and limited. Furthermore, we compare these protocols in terms of their quorum system characteristics, limitations, and performance. Finally, a guide for future research directions is presented.
Research on Car-Following Model considering Driving Style
Authors: Wang Keyin , Yang Yahui , Wang Sishan , Shi Zhen
Published: February 2022

In this paper, a car-following model considering various driving styles is constructed to fulfill the personalized needs of different users of autonomous vehicles. First, according to a set of selection rules, car-following events are selected from the Next Generation Simulation (NGSIM) dataset, and then through an unsupervised machine learning method, the extracted data are divided into two styles, i.e., conservative and aggressive. Statistical analysis is then conducted to analyze the differences in vehicle speed, acceleration, desired time headway, and so on between both driving styles. Based on the analysis, a car-following model based on model predictive control is designed. Experimental results from testing data show that the proposed car-following models demonstrate different driving styles in terms of safety, comfort, and effectiveness. The conservative driving model is safer and more comfortable than the radical driving model, but the driving efficiency is low.
A Comparison of the Blood Glucose, Growth Hormone, and Cortisol Responses to Two Doses of Insulin (0.15 U/kg vs. 0.10 U/kg) in the Insulin Tolerance Test: A Single-Centre Audit of 174 Cases
Authors: Yeoh Phillip , Dwyer Andrew A. , Anghel Ella , Bouloux Pierre M. , Khoo Bernard , Chew Shern , Wernig Florian , Carroll Paul , Aylwin Simon J. B. , Baldeweg Stephanie E. , Drake William , Todd Jeannie , Mangena Lindiwe , Grossman Ashley
Published: February 2022

Objective. The insulin tolerance test (ITT) is the gold standard endocrine test used to assess the integrity of the growth hormone (GH) and cortisol axes. The ITT has potential risks, and severe hypoglycaemia may necessitate intravenous glucose rescue. There is no clear consensus as to the optimal insulin dose for the ITT. Therefore, we sought to compare the standard dose (0.15 U/kg) and a low-dose ITT (0.1 U/kg). Design. Single-centre audit of ITT data (2012–2021). Patients and Measurements. Patients who underwent an ITT to assess possible GH deficiency/adrenal insufficiency were included. Glucose, GH, and cortisol were measured at baseline and 30, 45, 60, 90, and 120 minutes following I.V. insulin bolus (0.15 U/kg or 0.10 U/kg). Results. Of the ITTs performed, only 3/177 (1.7%) did not achieve adequate hypoglycaemia (≤2.2 mmol/L) with a single insulin dose. In total, 174 patients (43.5 ± 12.1 yrs, mean ± standard deviation) were included for analysis (0.15 U/kg: n = 113, 0.10 U/kg: n = 61). All 174 subjects had adequate hypoglycaemia regardless of baseline fasting blood glucose level or insulin dose. Neither nadir glucose nor glucose delta (i.e., baseline minus nadir) differed between insulin doses. Trends in both cortisol and GH responses over time were similar between groups, and a greater proportion of patients receiving the standard dose had an adequate cortisol response (77/106 (72.6%) vs. 32/60 (53.3%),

p
=
0.01

). The rates of glucose rescue did not differ in a subset of 79 patients, with on-demand glucose rescue in 4/35 (11%) for the standard dose and 2/44 (5%) for the low dose (

p
=
0.25

). Conclusions. Our results suggest that the low-dose ITT produces comparable glucose, cortisol, and GH responses to the higher dose. Given the risks associated with hypoglycaemia, the low dose appears to be preferable to the standard dose ITT in most circumstances.
Numerical Calculation Analysis and Characteristic Research on Windage Loss of Oil-Jet Lubricated Aviation Gear Pair
Authors: Li Linlin , Wang Sanmin , Zhang Xuyang , Li Zhibin , Li Fei , Zou Haoran
Published: February 2022

The VOF (volume of fluid) multiphase transient simulation model of the windage loss of the gear pair under oil-jet lubrication was carried out by using the dynamic mesh technology with the powerful parallel computing capabilities of the Super Cloud Computing Center. Firstly, a two-phase (oil-gas) turbulence numerical model was established in the process of oil-jet lubrication. The numerical simulation test was designed by orthogonal experiment. The influence of the oil-jet lubrication parameters and their interaction on the windage power loss was studied by means of variance analysis. The results showed that the influence of injection speed on the windage power loss was the largest and proportional, followed by injection temperature and injection pressure, and the latter two factors were inversely proportional. Then, the fitting calculation formula of windage loss related to each influencing factor is obtained based on the numerical simulation results. Furthermore, by observing the velocity vector distribution of the internal flow field of the gearbox with different time, the formation mechanism of windage loss is understood intuitively, and the measures to reduce windage loss are put forward. Finally, the mechanical and energy characteristics of the windage loss under different oil injection parameters are proposed, by analyzing and calculating the differential pressure force, viscous force, turbulent kinetic energy, and turbulent dissipation rate around the gear pair. This paper provides a method guidance for the calculation of windage power loss and efficiency of aviation gear pair under elastohydrodynamic lubrication in engineering application.
[Retracted] Understanding the Critical Role of Glycolysis‐Related lncRNAs in Lung Adenocarcinoma Based on Three Molecular Subtypes
Authors: Cao Peng , Zhao Bo , Xiao Yajie , Hu Shan , Kong Kangle , Han Peng , Yue Jiaqi , Deng Yu , Zhao Zhikun , Wu Dongfang , Zhang Lu , Li Fan
Published: February 2022

Background. Glycolysis is closely associated with tumor progression, but the roles of lncRNAs in glycolysis have not been comprehensively investigated in lung adenocarcinoma (LUAD). This study is aimed at studying the possible mechanisms of glycolysis‐related lncRNAs in tumor development and providing a guidance for targeted therapy. Methods. Unsupervised consensus clustering was used to identify molecular subtypes. Gene enrichment analysis was applied to screen important pathways involved in tumor progression. A series of immune analysis was performed to assess immune infiltration. Critical transcription factors (TFs) interacting with lncRNAs were selected by Pearson correlation analysis. A first‐order partial correlation analysis was implemented to identify critical lncRNAs with prognostic significance. Results. Three molecular subtypes (C1, C2, and C3) were identified with distinct overall survival. Three subtypes showed differential immune infiltration, and C3 subtype was the optimal for immunotherapy treatment. Ten lncRNA‐TF pairs among four glycolysis‐related lncRNAs (FTX, LINC00472, PSMA3‐AS1, and SNHG14) and six TFs (FOXP1, SP1, MYC, FOXM1, HIF1A, and FOS) were involved in tumor progression. We identified four critical glycolysis‐related lncRNAs significantly associated with prognosis. Conclusions. This study identified three molecular subtypes that could guide personalized therapy. The four‐lncRNA prognostic model can serve as an indicator for predicting prognosis or early screening of lung adenocarcinoma patients. The current results improve the understanding of the relation between lncRNAs and glycolysis.
Characteristics of Aerobics and Nutrition Strategy Based on Depth Image Human Body Recognition
Authors: Cheng Liangliang , Nie Dongfang
Published: February 2022

Bodybuilding operation is a favorite sports item, which is beneficial to enhance physical fitness, improve coordination and flexibility of movement, and enhance cardiopulmonary function. Standard aerobics movements and nutrition matching strategies can more effectively enhance the exercise effect. In this paper, the characteristics of aerobics, sports, and nutrition strategies are researched through the human body recognition technology of the depth image; the subjects were divided into four groups by statistical method and control variable experiment method. They were the control group, the experimental group for aerobics training, the experimental group for improving the nutritional balance under diet, and the experimental group for aerobics training. After two and a half months of experimental training and observation, the students in the four groups were tested for physical fitness and physical function; analyze the obtained experimental test data using the human body recognition technology of depth image, then obtain the experimental test data, and then use the data fusion method to combine the data and information for more accurate evaluation. The results showed that after 10 weeks of aerobics learning and nutrition, the average height of students increased by 1.19 cm, the average weight decreased by 1.17 kg, the number of sit-ups increased from 23.9 before the experiment to 31.2, and the results of 50-meter race and 800-meter run were 0.2 seconds and 2.9 seconds, respectively. It can be concluded that aerobics and nutrition can speed up metabolism, promote the growth and development of bones, and supplement the nutrition needed by the human body, to improve students’ physical quality. This study contributes to the research of sports and nutrition matching in improving physical conditions.
Intrusive Seismic Swarms as Possible Precursors of Destructive Earthquakes on Mt. Etna’s Eastern Flank
Authors: Gambino Salvatore , Distefano Giovanni
Published: February 2022

The Timpe Fault System (TFS) represents the source of shallow earthquakes that strike numerous towns and villages on Mt. Etna’s eastern flank. In the last 40 years, three destructive seismic events reached

I

0

=
VIII
 
EMS

(heavily damaging) in 1984 (October 25), 2002 (October 29), and 2018 (December 26). These events followed a few days after the occurrence of strong seismic swarms and the sudden acceleration of the eastern flank seaward. The damaging seismic events in 2002 and 2018 were associated with dike intrusions and eruptions of the volcano; however, no eruptive activity was observed at the time of the 1984 earthquakes. In this study, we investigate seismic parameters for the 1984 sequence, in order to interpret the seismicity in terms of volcanic activity. Parameters such as localization, cumulative seismic moment, and hourly occurrence frequency of the 1984 seismic swarm have been analysed and shown to have typical values of Mt. Etna’s intrusive seismic swarms. This suggests that the 1984 episode may have been an aborted intrusive magma episode that triggered similar processes (long and powerful intrusions with acceleration of the eastern flank movement and destructive earthquakes), as in 2002 and 2018. These three episodes suggest that an evaluation of some seismic parameters during future intrusive swarms may furnish indications of a possible reactivation of the TFS.
Constraint-Following Approach for Platoon Control Strategy of Connected Autonomous Vehicles
Authors: Hu Mengyan , Gao Ying , Zhao Xiangmo , Tian Bin , Xu Zhigang
Published: February 2022

The current platoon control strategies of connected autonomous vehicles (CAVs) focus on controlling the fixed intervehicle distance, i.e., the string stability of the platoon system. Here, we aimed to design a CAV platoon control strategy based on a constraint-following approach to solve the problem of platoon starting. As the resistance of the vehicle during driving varies with time, this study regarded the CAV platoon system as a changing dynamic system and introduced the Udwadia–Kalaba (U–K) approach to simplify the solution. Apart from adding an equality constraint, unlike most other studies, this study imposed a bilateral inequality constraint on the intervehicle distance between successive CAVs to prevent collisions. Meanwhile, a diffeomorphism method was introduced to transform the bounded state into an unbounded state. The proposed control strategy could render each CAV compliant with both the original imposed bilateral inequality constraint and the equality constraint. The former avoids collisions, and the latter indicates the string stability of the designed CAV platoon system. The effectiveness of the proposed controller was verified by numerical experiments. The gap errors tend to converge to zero, which is not amplified by the propagation of traffic flow.
Protective Effects of the Wenfei Buqi Tongluo Formula on the Inflammation in Idiopathic Pulmonary Fibrosis through Inhibiting the TLR4/MyD88/NF‐κB Pathway
Authors: Song Siyu , Wang Jing , Liu Guanwen , Ding Lu , Li Yaxin , Qi Hongyu , Wei Lai , Zhao Jiachao , Chen Tian , Zhao Meiru , Wang Ziyuan , Yang Yingying , Zhao Daqing , Li Xiangyan , Wang Zeyu
Published: February 2022

Background. Idiopathic pulmonary fibrosis (IPF) is a progressive disease with high mortality and poor prognosis. The prognostic signatures related to conventional therapy response remain limited. The Wenfei Buqi Tongluo (WBT) formula, a traditional Chinese medicine (TCM) formula, has been widely utilized to treat respiratory diseases in China, which is particularly effective in promoting inflammatory absorption. In this study, we aim to explore the mechanism of the WBT formula in the inhibition of inflammatory response during IPF, based on network pharmacology and in vivo experiments. Methods. Network pharmacology was applied to predict the changes of biological processes and potential pathways for the WBT formula against IPF. Histopathological changes, inflammatory factors (IL‐6, IL‐1β, and TNF‐α), and the proteins of the TLR4/MyD88/NF‐κB pathway in bleomycin‐ (BLM‐) induced mice model were examined by hematoxylin‐eosin (H&E), Masson or immunohistochemistry staining, Western blot, and enzyme‐linked immunosorbent assay analysis. Results. A total of 163 possible components and 167 potential targets between the WBT formula and IPF were obtained. The enrichments of network pharmacology showed that inflammation response, TNF, and NF‐κB pathways were involved in the treatment of WBT against IPF. The in vivo experiments indicated that the WBT formula could ameliorate inflammatory exudation and collagen deposition at a histopathology level in the BLM‐induced mice model. The levels of IL‐6, IL‐1β, and TNF‐α were reduced after the WBT formula treatment. Moreover, the expressions of phosphorylated‐NF‐κB p65, TLR4, and MyD88 were significantly downregulated by the WBT formula, compared with the BLM‐induced group. Conclusion. These results indicated that the WBT formula can suppress BLM‐induced IPF in a mouse model by inhibiting the inflammation via the TLR4/MyD88/NF‐κB pathway. This study provides a new insight into the molecular mechanisms of the WBT formula in the application at the clinic.
Semantic Association and Decision-Making for the Internet of Things Based on Partial Differential Fuzzy Unsupervised Models
Authors: Liu Wansu , Lu Biao
Published: February 2022

This study presents an in-depth study and analysis of IoT semantic association and decision-making using a partial differential fuzzy unsupervised approach. It focuses on a semantic annotation framework for device metadata and a knowledge base construction method to further improve the interoperability of IoT domain knowledge by building a unified IoT domain knowledge base and designing and implementing a semantic IoT knowledge management and application generation system. The main proposal is an IoT generic domain ontology, which reuses the existing excellent ontologies of IoT as much as possible, extracts the commonly used concepts of the domain and combines them, and provides a unified semantic template for IoT applications. On the other hand, by applying the entity linking technique to the extension of the knowledge base and linking the structured metadata of devices to the corresponding entities of the background knowledge base, the domain knowledge base can be made to share the rich background knowledge. At the same time, the interoperability of heterogeneous IoT metadata between applications is enhanced by unifying data and concepts from different device applications to the same background knowledge base through entity alignment techniques. The semantic representation of events applicable to IoT application scenarios is investigated, and an IoT event ontology for representing abstract events and event relationships in IoT is designed; next, a domain ontology with IoT sensing and control event representation capability is constructed based on the IoT event ontology, in which the typical domain ontology (SSN) that can be used for IoT applications is followed by the ontology reuse principle is improved and extended to support the description of event types and interevent relationships, and the IoT event model is associated with the improved IoT base ontology through an ontology alignment approach. Finally, the IoT sensing and control ontology are validated by semantic modeling of device composition, component relationships, and operational processes based on the IoT sensing and control ontology.
Poststroke Cognitive Impairment Research Progress on Application of Brain‐Computer Interface
Authors: Sun Xiaowei , Li Mingyue , Li Quan , Yin Hongna , Jiang Xicheng , Li Hongtao , Sun Zhongren , Yang Tiansong
Published: February 2022

Brain‐computer interfaces (BCIs), a new type of rehabilitation technology, pick up nerve cell signals, identify and classify their activities, and convert them into computer‐recognized instructions. This technique has been widely used in the rehabilitation of stroke patients in recent years and appears to promote motor function recovery after stroke. At present, the application of BCI in poststroke cognitive impairment is increasing, which is a common complication that also affects the rehabilitation process. This paper reviews the promise and potential drawbacks of using BCI to treat poststroke cognitive impairment, providing a solid theoretical basis for the application of BCI in this area.
Design of a Highly Efficient Subwavelength Antireflective Structure for Solar Cells
Authors: Chen Lin , Huang Zhao
Published: February 2022

An efficient optical antireflective (AR) structure plays a vital role in high-performance thin-film solar cells. Here, we design a surface relief AR structure consisting of a two-dimensional (2D) array of a subwavelength ring and pillar-shaped feature, capable of suppressing optical reflection over a wide spectral window of the solar spectrum. Our simulations show that the weighted average reflectance of the subwavelength AR structure is as low as 4.2% in the 400–1100 nm spectral range in the normal incidence condition and almost 10-fold reduction compared with a bare silicon surface. When placed on the front side of a simple Si thin-film photovoltaic solar cell, this subwavelength AR structure leads to an improved light absorption with simulated results showing an increase of 53% short-circuit current compared to a flat solar cell. Besides, our simulations show that this AR structure could, in principle, perform well against reasonable fabrication errors.
Risk Assessment for Patients with Chronic Respiratory Conditions in the Context of the SARS-CoV-2 Pandemic Statement of the German Respiratory Society with the Support of the German Association of Chest Physicians
Authors: Lommatzsch Marek , Rabe Klaus F. , Taube Christian , Joest Marcus , Kreuter Michael , Wirtz Hubert , Blum Torsten Gerriet , Kolditz Martin , Geerdes-Fenge Hilte , Otto-Knapp Ralf , Häcker Brit , Schaberg Tom , Ringshausen Felix C. , Vogelmeier Claus F. , Reinmuth Niels , Reck Martin , Gottlieb Jens , Konstantinides Stavros , Meyer Joachim , Worth Heinrich , Windisch Wolfram , Welte Tobias , Bauer Torsten
Published: February 2022

Assessing the risk for specific patient groups to suffer from severe courses of COVID-19 is of major importance in the current SARS-CoV-2 pandemic. This review focusses on the risk for specific patient groups with chronic respiratory conditions, such as patients with asthma, chronic obstructive pulmonary disease, cystic fibrosis (CF), sarcoidosis, interstitial lung diseases, lung cancer, sleep apnea, tuberculosis, neuromuscular diseases, a history of pulmonary embolism, and patients with lung transplants. Evidence and recommendations are detailed in exemplary cases. While some patient groups with chronic respiratory conditions have an increased risk for severe courses of COVID-19, an increasing number of studies confirm that asthma is not a risk factor for severe COVID-19. However, other risk factors such as higher age, obesity, male gender, diabetes, cardiovascular diseases, chronic kidney or liver disease, cerebrovascular and neurological disease, and various immunodeficiencies or treatments with immunosuppressants need to be taken into account when assessing the risk for severe COVID-19 in patients with chronic respiratory diseases.
Profiling and Bioinformatics Analysis Revealing Differential Circular RNA Expression about Storage Lesion Regulatory in Stored Red Blood Cells
Authors: Zhang Yiyu , Huang Guoqing , Yuan Zhaohu , Zhang Yonggang , Chen Xiaojie , Huang Jianyun , Li Nan , Liu Zhen , Zhong Weijie , Huang Huikang , Huang Canze , Wei Yaming
Published: February 2022

Introduction: Circular RNA (circRNA) plays an important role in regulating metabolism of red blood cells (RBCs) and their storage lesions, but the study of how circRNA expression changes in stored RBCs has rarely been conducted. Methods: The expression change of circRNA was systemically evaluated via high-throughput sequencing on healthy RBCs on day 0, 20, and 40. And then we confirmed the reliability of the high-throughput sequencing analysis by RT-qPCR characterization on selected circRNAs. A higher parental gene enrichment was used to explore circRNA function in pathways. In addition, we deciphered a dysregulated circRNA-related ceRNAs network, and identified three circRNA-miRNA-mRNA regulatory axes related to storage lesion. Results: We identified 2,586 known and 6,216 putative novel circRNAs, more than 100 circRNAs expression levels were shifted, and the number of downregulated circRNAs was greater with longer storage time. Furthermore, a higher parental gene enrichment related to circRNA was found in pathways, including cAMP signaling pathway, ubiquitin-mediated proteolysis, apoptosis, adhesion, MAPK signaling pathway, cystine methionine metabolism, RNA degradation, RNA transport, TGF-β, and actin regulatory pathway. hsa_circ_0007127-miR-513a-5p-SMAD4, hsa_circ_0000033-miR-19a-3p-VAMP3, and hsa_circ_0005546-miR-4720-CCND3 regulatory axes related to storage lesion was found. Conclusions: Through investigation in circRNAs profile and circRNA-miRNA-mRNA interactions, this study provides insights on stored RBC circRNA expression changes, which closely relate to the storage lesion of RBCs and their physiological functions.
Primary Renal Synovial Sarcoma Case Series: Clinical Profile and Management of a Rare Entity
Authors: Raja Anand , Ratnagiri Ranganath , MSS Keerti , Malik Kanuj , Menon Arun R.
Published: February 2022

Synovial sarcomas occur predominantly in the extremities. Primary renal synovial sarcoma is a rare entity. Very few cases have been reported in the literature. Clinical and radiological features are similar to renal cell carcinoma with the diagnosis being established after surgery based on histopathology, immunohistochemistry, and chromosome studies. There are no established guidelines on the role of adjuvant treatment in the management of this disease. We herein present a series of 3 cases managed at 2 institutions. In the current series, all patients had venous thrombus, and surgery was the mainstay of treatment. One patient received neoadjuvant chemotherapy after a preoperative biopsy which was done as she did not respond to chemotherapy for a presumptive diagnosis of Wilm’s tumor.
Positioning Aeromonas Infection in Inflammatory Bowel Disease: A Retrospective Analysis
Authors: Pereira Guedes Tiago , Alves Silva Joana , Neves Sara , Falcão Daniela , Costa Paula , Lago Paula , Pedroto Isabel , Salgado Marta
Published: February 2022

Background and Aim: Aeromonas are Gram-negative rods known to cause a spectrum of diseases. Inflammatory bowel disease (IBD) is an idiopathic complex condition resulting from interaction of multiple factors. Aeromonas infection in association with IBD is still largely unknown. We aim to look for the significance of Aeromonas infection and for significant differences between IBD and non-IBD patients. Methods: A retrospective observational analysis was performed of all patients positive for Aeromonas in stool cultures, during a 10-year period, from a tertiary and university hospital. Results: Fifty patients were included, 56% male with a mean age of 42.1 years. Thirty-eight (76%) were non-IBD and 12 (24%) IBD patients. IBD patients were more frequently under immunosuppressors. Two patients were asymptomatic and 44% developed mild, 44% moderate, and 16.7% severe infection. The main strains isolated were Aeromonas hydrophila/caviae. Bacterial co-isolation was found in 4 non-IBD and histological findings of cytomegalovirus in 2 IBD patients. Non-IBD patients presented more frequently with fever and IBD patients with bloody diarrhea and abdominal pain. There was higher tendency for severe infection rate in IBD patients with higher antimicrobial therapy use. Steroids were exclusively used in the IBD group. From IBD, 4 patients had the diagnosis of ulcerative colitis and 9 of Crohn’s disease with colonic involvement. Of these patients, 5 received IBD diagnosis after the acute episode of Aeromonas infection. Conclusions: Clinical presentation of Aeromonas infection differs between IBD and non-IBD patients. Non-IBD patients had milder severity of infection with less use of antibiotics. Aeromonas infection seems to greatly contribute to IBD manifestation.
Prognostic Value of Pretreatment Inflammatory Markers in Patients Receiving Radical Cystectomy for Urothelial Bladder Cancer: Does Age Matter?
Authors: Volz Yannic , Pfitzinger Paulo L. , Eismann Lennert , Ebner Benedikt , Jokisch Friedrich , Schulz Gerald Bastian , Buchner Alexander , Schlenker Boris , Stief Christian G. , Rodler Severin
Published: February 2022

Introduction: Biomarkers are known predictors for survival after radical cystectomy (RC) and can improve patient stratification. Yet, it remains unclear how age influences their prognostic value. The current study aimed to assess the impact of age on standard prognostic biomarkers in different age-groups. Materials and Methods: Overall, 1,014 patients undergoing RC for bladder cancer were included. Patients were divided into age-groups (I – <60, II – 60–69, III – 70–79, and IV – ≥80). C-reactive protein (CRP), hemoglobin (Hb), thrombocytes, and leucocytes prior to RC were used as biomarkers. The Kaplan-Meier method and log-rank test were used to compare overall survival (OS) and cancer-specific survival (CSS). For independent predictors of survival, multivariate models were applied. Results: Absolute levels of biomarkers except CRP revealed a significant decrease with increasing age. We found low Hb to be associated with impaired CSS in groups II (2.05 [1.32–3.17]; p = 0.001), III (2.83 [2.01–4.00]; p < 0.001), and IV (1.79 [1.12–2.84]; p = 0.014). Thrombocytes above the cutoff were associated with impaired CSS and OS in groups II, III, and IV for CSS and OS. Leukocytes were associated with impaired CSS and OS in group II (2.11 [1.38–3.23]; p < 0.001 and 1.99 [1.36–2.90]; p < 0.001) and III (1.70 [1.08–2.67]; p = 0.021 and 1.80 [1.25–2.58]; p = 0.002). Elevated CRP was associated with impaired CSS and OS across all groups. Conclusion: Biomarkers are predictors for survival after RC. Yet, their impact on survival is less in the oldest patient group. Therefore, careful patient stratification and treatment administration should be considered in elderly patients. Further investigations are needed to fully understand the underlying mechanisms.
Língua, Modernidade e Tradição
Authors: Fiorin José Luiz
Published: February 2022

Língua, Modernidade e Tradição
Literatura e Liminaridade
Authors: Dutra Robson
Published: February 2022

Literatura e Liminaridade
Entrevista com Mestre Alcides de Lima
Authors: Da Costa Ana Carolina Francischette
Published: February 2022

Mestre Alcides de Lima é mestre de capoeira do grupo Centro de Estudos e Aplicação da Capoeira (CEACA), integra a Comissão Nacional dos Mestres da Rede Ação Griô Nacional, engajada na discussão e elaboração de políticas públicas de reconhecimento de Mestres Griôs detentores dos saberes e fazeres de tradição oral no Brasil. Licenciado em Educação Física e Pedagogia com habilitação em Administração Escolar e Orientação Educacional. É técnico especializado de apoio ao ensino e pesquisa na área de Oceanografia Química do Instituto Oceanográfico da Universidade de São Paulo (USP), participando do Programa Antártico-Brasileiro. Há mais de 20 anos desenvolve projetos ligados à cultura de tradição oral no interior de escolas públicas, atualmente através da coordenação do Ponto de Cultura Amorim Rima/ CEACA Capoeira e Cultura Brasileira e do Projeto “Expresse-se com consciência – Faça capoeira”.
Território do significado: a cultura boliviana e a interculturalidade na rede municipal de São Paulo
Authors: Carvalho Francione Oliveira
Published: February 2022

Desde a implementação do Mercosul vemos o fluxo de imigrantes sul-americanos aumentar tanto nas regiões de fronteira como nas grandes cidades brasileiras, caso da capital paulista. A globalização das sociedades contemporâneas também ressignifica o sentido da cidadania, pois as cidades tornam-se palimpsestos de referências e pertencimentos. Diferentes possibilidades de ser passam a conviver no mesmo território, abrindo fendas para a problematização sobre o próprio conceito de território, que deixa de ficar encerrado no espaço físico. Ao produzir significados a partir do espaço, os homens produzem cultura, identidade e estabelecem um campo de poder. Podemos nomear um “território do significado” (CARVALHO, 2011), que indo além da noção geográfica de delimitação e ocupação do espaço, dialoga com as estruturas de sentimentos, experiências, crenças e valores que produzem o reconhecimento e o pertencimento aos grupos. Este artigo resultado da pesquisa de Pós-Doutoramento no Diversitas Núcleo de Estudos das Diversidades, Intolerâncias e Conflitos da USP sob a supervisão da Profª Drª Zilda Márcia Grícoli Iokoi traz uma reflexão sobre a presença dos alunos estrangeiros na Rede Municipal de São Paulo, com destaque para os de origem boliviana matriculados na EMEF Infante Dom Henrique, localizada no bairro do Pari.  Durante 16 meses o pesquisador acompanhou o cotidiano da escola e participou do Projeto Escola Apropriada: educação, cidadania e direitos humanos, que nesse texto é apresentado e discutido.
Filosofia ecofeminista: Repensando o feminismo a partir da lógica a dominação
Authors: Rosendo Daniela
Published: February 2022

Apartir da conexão conceitual, a filósofa ecofeminista Karen J. Warren explica a existência de estruturas conceituais opressoras, entendidas como um conjunto de crenças básicas, valores, atitudes e pressupostos que dão forma e refletem como alguém vê a si mesmo e ao mundo, que contêm em si a lógica da dominação, que é uma estrutura de argumentação que visa justificar a subordinação. A partir da análise das estruturas conceituais, Warren defende a necessidade de repensar o feminismo a fim de acolher o ecofeminismo, segundo o qual a consideração moral de não-humanos deve ser incorporada e o naturismo, enquanto sistema de dominação, abolido
Filmes populares de animação e as narrativas sobre humanos e outros animais
Authors: Vizachri Tânia Regina
Published: February 2022

Partindo do pressuposto que anima- ções infantis são artefatos culturais que veiculam significados do que é e de como deveria ser o humano e que tipo de relações estes deveriam estabelecer com os animais, este artigo apresenta uma reflexão sobre os principais resultados da análise realizada na dissertação de mestrado Animais humanos ou humanos animais: Um estudo sobre a representação dos animais antropomorfizados nos filmes de animação a fim de mostrar como os filmes de animação têm discutido os direitos animais. Por fim, será feita uma breve reflexão sobre se essas animações podem auxiliar no desenvolvimento da empatia pelas outras espécies de animais
A reescrita dos mitos bíblicos em José Saramago: a re-historização do sagrado a partir da ficção
Authors: Lima da Silva Francisca Carolina
Published: February 2022

Uma das temáticas predominantes na obra de José Saramago é a releitura e a intertextualidade com a história e com os mitos fundadores do ideário ocidental. Essa prática se constrói a partir de uma desconstrução dos textos com os quais as obras dialogam, por meio do uso da paródia, da metaficção historiográfica e da alegoria. Nesses textos, Saramago, ao mesmo tempo em que questiona crenças inabaláveis, apresenta-nos a desmistificação da História oficial, oportunizando, assim, o emanar das histórias silenciadas, a partir daquilo que poderia ter sido. O presente artigo pretende analisar o processo de releitura que o autor realiza na obra O Evangelho segundo Jesus Cristo (2005), ao utilizar como fonte as ruínas históricas deixadas pela leitura dogmática do Novo Testamento do Judaísmo Cristão. Para tanto, faremos uso da teoria moderna da alegoria desenvolvida por Walter Benjamin, com amparo nos preceitos da Literatura Comparada, a partir do dialogismo bakhtiniano que o texto de Saramago constrói, não só com as versões canônicas dos textos bíblicos, mas também com os escritos apócrifos, também utilizando dados da história e da cultura moderna.
O heterônimo ortônimo e o Álvaro de Campos: Do tempo mítico ao tempo das efêmeras sensações
Authors: Boniatti André , Vasconcelos Ana Maria Martins Alves
Published: February 2022

Sabe-se que os mistérios que se ocultam perante a imarcescível imaginação de Fernando Pessoa, poeta português moderno, são ainda motivo de estudos profundos, tanto mais mediante a popularidade que o poeta alcançou com o reconhecimento após sua morte, dele merecido, e a passagem dos anos. O presente artigo, perante as diversas inquietações que sua obra suscita, investiga um dos vieses da relação que pode ser estabelecida entre os heterônimos pessoanos Álvaro de Campos e Pessoa ele mesmo, ortônimo, almejando compreender tanto as raízes que lhe conturbam a sua efetivação material identitária, quanto a tentativa que empreende em conceber-se alguém. Assim, o próprio Pessoa ele mesmo, tratamo-lo aqui como heterônimo, visto entendermos a identidade pessoana perdida entre suas personas imaginadas/desenhadas por si. No decorrer da leitura, essa proposição mostra-se clara, em face do entendimento de o poeta heteronímico Campos apresentar-se o “eu” mais próprio de Fernando, trazendo à tona ao menos uma possibilidade de agrupamento de sua multiplicidade.
diagnóstico do absurdo na poesia de Nuno Félix da Costa
Authors: Gomes Daniel de Oliveira
Published: February 2022

Analisamos os livros de poesias intitulados “O desfazer das coisas e as coisas já desfeitas” (2015) e “Agora nos” (2012), do autor e psiquiatra Nuno Félix da Costa. Trata-se de um autor contemporâneo de origem portuguesa. Sua poesia se apresenta ao modo de instigantes monólogos filosóficos, como aforismos poéticos beirando o absurdo. Dentre os temas e conceitos que abordamos constam: os paradoxos da instituição literária; a acefalidade; a arqueologia; a loucura e a liberdade da poesia. Sendo um psiquiatra, o autor, enquanto poeta, vai contra as instâncias de poder como as da psiquiatria, buscando um diagnostico do absurdo pela poesia.
Antologia Dialogante de Poesia Portuguesa Escolha e apresentação de Rosa Maria Martelo Porto: Assírio & Alvim, 2020.
Authors: Brito Nuno
Published: February 2022

Resumo: Antologia Dialogante de Poesia Portuguesa é a mais recente publicação organizada pela poeta, ensaísta e professora Rosa Maria Martelo e constitui uma selecção de textos poéticos que dialogam intertextualmente, constituindo-se como uma obra central para o estudo das relações intertextuais no interior da poesia portuguesa contemporânea e da poesia mais recente com a tradição literária anterior, da idade média, ao renascimento, passado pelo modernismo português, o surrealismo ou as criações mais atuais.
A narrativa literária de Heródoto e Ctésias: um ensaio comparativo sobre o papel social e o poder feminino na Pérsia Aquemênida dos séculos VI-V AEC
Authors: Maluf Matheus Moraes
Published: February 2022

Ao lermos Heródoto e Ctésias, podemos compreender que a mulher Persa, principalmente da Corte, em específico a Rainha, possuía um poder acima das demais, exercendo um papel social e político de grande influência. O presente artigo pretende analisar e ensaiar uma comparação em como esses autores helênicos representavam essas mulheres Reais através de seus textos, nas passagens em que há mais ênfase sobre o papel feminino na sociedade helênica e Corte Aquemênida.