bluuebunny/crossref_metadata_2025 huggingface dataset:
Bladder Cancer and Risk Factors: Data from a Multi-Institutional Long-Term Analysis on Cardiovascular Disease and Cancer Incidence
Authors: Barone Biagio , Finati Marco , Cinelli Francesco , Fanelli Antonio , Del Giudice Francesco , De Berardinis Ettore , Sciarra Alessandro , Russo Gianluca , Mancini Vito , D’Altilia Nicola , Ferro Matteo , Porreca Angelo , Chung Benjamin I. , Basran Satvir , Bettocchi Carlo , Cormio Luigi , Imbimbo Ciro , Carrieri Giuseppe , Crocetto Felice , Busetto Gian Maria
Published: March 2023

Background: Bladder cancer (BCa) is a heterogeneous disease with a variable prognosis and natural history. Cardiovascular disease (CVD), although completely different, has several similarities and possible interactions with cancer. The association between them is still unknown, but common risk factors between the two suggest a shared biology. Materials and Methods: This was a retrospective study that included patients who underwent transurethral resection of bladder tumor at two high-volume institutions. Depending on the presence of a previous history of CVD or not, patients were divided into two groups. Results: A total of 2050 patients were included, and 1638 (81.3%) were diagnosed with bladder cancer. Regarding comorbidities, the most common were hypertension (59.9%), cardiovascular disease (23.4%) and diabetes (22.4%). At univariate analysis, independent risk factors for bladder cancer were age and male sex, while protective factors were cessation of smoking and presence of CVD. All these results, except for ex-smoker status, were confirmed at the multivariate analysis. Another analysis was performed for patients with high-risk bladder cancer and, in this case, the role of CVD was not statistically significant. Conclusions: Our study pointed out a positive association between CVD and BCa incidence; CVD was an independent protective factor for BCa. This effect was not confirmed for high-risk tumors. Several biological and genomics mechanisms clearly contribute to the onset of both diseases, suggesting a possible shared disease pathway and highlighting the complex interplay of cancer and CVD. CVD treatment can involve different drugs with a possible effect on cancer incidence, but, to date, findings are still inconclusive.
Refining the Intraoperative Identification of Suspected High-Grade Glioma Using a Surgical Fluorescence Biomarker: GALA BIDD Study Report
Authors: Watts Colin , Dayimu Alimu , Matys Tomasz , Ashkan Keyoumars , Price Stephen , Jenkinson Michael D. , Doughton Gail , Mather Claire , Young Gemma , Qian Wendi , Kurian Kathreena M.
Published: March 2023

Background. Improving intraoperative accuracy with a validated surgical biomarker is important because identifying high-grade areas within a glioma will aid neurosurgical decision-making and sampling. Methods. We designed a multicentre, prospective surgical cohort study (GALA-BIDD) to validate the presence of visible fluorescence as a pragmatic intraoperative surgical biomarker of suspected high-grade disease within a tumour mass in patients undergoing 5-aminolevulinic acid (5-ALA) fluorescence-guided cytoreductive surgery. Results. A total of 106 patients with a suspected high-grade glioma or malignant transformation of a low-grade glioma were enrolled. Among the 99 patients who received 5-ALA, 89 patients were eligible to assess the correlation of fluorescence with diagnosis as per protocol. Of these 89, 81 patients had visible fluorescence at surgery, and 8 patients had no fluorescence. A total of 80 out of 81 fluorescent patients were diagnosed as high-grade gliomas on postoperative central review with 1 low-grade glioma case. Among the eight patients given 5-ALA who did not show any visible fluorescence, none were high-grade gliomas, and all were low-grade gliomas. Of the seven patients suspected radiologically of malignant transformation of low-grade gliomas and with visible fluorescence at surgery, six were diagnosed with high-grade gliomas, and one had no tissue collected. Conclusion. In patients where there is clinical suspicion, visible 5-ALA fluorescence has clinical utility as an intraoperative surgical biomarker of high-grade gliomas and can aid surgical decision-making and sampling. Further studies assessing the use of 5-ALA to assess malignant transformation in all diffuse gliomas may be valuable.
Rural E-Customers’ Preferences for Last Mile Delivery and Products Purchased via the Internet before and after the COVID-19 Pandemic
Authors: Markowska Małgorzata , Marcinkowski Jakub , Kiba-Janiak Maja , Strahl Danuta
Published: March 2023

The purpose of this paper is to assess the impact of the COVID-19 pandemic on rural e-customers’ preferences in terms of last mile delivery and products purchased via the Internet. This paper is based on the theory of last mile delivery (with a strong focus on the methods of delivery) and customers’ preferences. It combines both theories to fulfil the paper’s goal. In the paper, the literature review and multivariate data analysis of rural e-customers in Poland were used. The hypothesis states that there is a requirement for different last mile delivery solutions in rural areas than in urban areas in Poland. The research was carried out on a sample of 1071 adult Poles, who are residents of rural areas, using the standardized and structured computer-assisted interview (CAWI). The authors used the chi-square independence test, the Student t-test, one-way analysis of variance (ANOVA), regression models, and logistic models. The research shows that more than 60% of respondents living in rural areas order goods purchased online with a home delivery method and that online shopping preferences’ changes are not so significant after the occurrence of COVID-19. Both before and after the pandemic, rural e-customers made online purchases most often 2–3 times a month. Nevertheless, some differences in the preferences of rural e-customers in terms of last mile delivery and purchasing preference can be seen considering their age, gender, or family size. The survey found that smaller families were more likely to choose free home delivery with a free return after the pandemic. The research presented in this paper provides essential information for courier companies, stores, and online platforms alike. Knowledge of preferences and their changes after the occurrence of COVID-19 can support the reorganization of last mile delivery to meet the needs of e-customers and to adapt to the increasing demands for sustainable transportation.
Understanding Factors Influencing Click-Through Decision in Mobile OTA Search Engine Systems
Authors: Gao Hongming , Zhan Mingjun
Published: March 2023

Mobile commerce has changed the decision environment for users who intend to reserve a preferred hotel. This study aims to investigate the factors that affect the dynamic click-through decision (CTD) in mobile online travel agency (OTA) search engines. We propose a dynamic Bayesian inference framework to model individual-level users’ CTDs and examine the effects of item position, price, search cost, and the use of refinement tools. The study uses real-world search log datasets from a global OTA for both mobile and desktop searches. Our results show that (1) the primacy effect is weaker and the effect of item-ranking positions is non-linear in a mobile OTA search compared to a desktop OTA search. Mobile users pay the most attention to the top-ranking results and are less likely to click through the middle or bottom results. (2) Hotel prices have a positive effect on mobile CTDs in the whole mobile searching journey. Additionally, mobile users also tend to seek out hotels with lower price rankings on the current search engine result page. (3) The search cost, measured by the cumulative time duration, has a positive impact on mobile CTDs. The use of refinement tools enhances the effect of search cost. This study extends previous research on position and price effects in an online consumer search from PC-based internet to mobile devices. It also provides managerial implications for mobile OTA search engine marketing and investment for bidding ranking positions.
Spatial Study of Enzymatic Activities from Bacterial Isolates in a Mediterranean Urban Park
Authors: Maicas Sergi , Segura-Garcia Jaume
Published: March 2023

Urban parks are a rich source of microbial diversity, as they are heavily used by city residents. In this study, we sampled a Mediterranean park and were able to isolate bacteria that have the ability to inhibit the growth of control microorganisms. Out of the 560 bacteria we tested, many displayed antibacterial activity, particularly against Salmonella sp. and K. pneumoniae. These results suggest that the microorganisms in the park are in close proximity to the human population. Additionally, the isolated bacteria demonstrated diverse enzymatic activities, possibly as a response to the environmental substances available to them, which could aid in the degradation of different compounds of interest. The study of the spatial distribution of soil parameters and the inhibition against relative-safe pathogens in an urban park in València (Spain) demonstrated a higher proportion of isolates in certain areas. These spatial data maps can help researchers understand the behaviors of bacterial populations on a regional level, which can assist in the creation of novel antimicrobial agents and promote advancements in public health.
Corporate Criminal Liability: An Overview of the Croatian Model after 20 Years of Practice
Authors: Vuletic Igor
Published: March 2023

The Croatian legislators introduced the concept of criminal liability for legal entities already in 2003 with the adoption of the Law on Criminal Liability of Legal Entities. Influenced by the writing of esteemed domestic scholars, and inspired by French law, the legislators opted for a system linking the liability of corporations to the liability of the responsible person. There were very few cases in practice during the first years of its application, and the situation changed after the first prominent indictment of this type against the ruling political party for economic crimes. Since then, the legislation has been amended several times and a significant body of jurisprudence has developed. In the first part of this paper, I will describe the chronology of the development and formation of the Croatian legislative model of corporate criminal liability. The second part will analyze 31 available final court judgments, which will be the basis for the conclusion about the issues in the practical application of the legislative model and, more generally, the phenomenon of criminal offenses committed by legal entities in Croatia. Based on this analysis, I will indicate the potential deficiencies of such a concept. In the context of future development, special attention will be given to the problem of economic crimes committed by AI corporate systems.
Outcomes in COVID-19 Patients with Pneumonia Treated with High-Flow Oxygen Therapy and Baricitinib—Retrospective Single-Center Study
Authors: Obradović Dušanka , Popović Milica , Banjac Maja , Bulajić Jelena , Đurović Vladimir , Urošević Ivana , Milovančev Aleksandra
Published: March 2023

Background. The aim of the study was to assess the effect of baricitinib on 28-day all-cause mortality and the progression of respiratory failure in patients needing transfer to the intensive care unit (ICU) with COVID-19 pneumonia treated with high-flow oxygen therapy. Methods. This retrospective study included hospitalized patients with COVID-19 pneumonia treated with high-flow oxygen non-invasive ventilation receiving standard of care (SOC) or SOC in addition to baricitinib. Data on patients’ characteristics, pro-inflammatory markers, D dimer, and National Early Warning Score 2 (NEWS2) values were collected and compared between groups. The primary endpoint was 28-day all-cause in-hospital mortality and the secondary outcome was transfer to the ICU. Results. The study included 125 patients. The primary outcome was observed in 44.8% of them: 27% in the baricitinib group vs. 62% in the SOC group, p < 0.001. Transfer to the ICU ward was significantly lower in the baricitinib group: 29% vs. 81%, p < 0.001. A significant improvement was observed when the baricitinib group was compared to SOC in procalcitonin, CRP, D-dimer, neutrophil-to-lymphocyte ratio values, and NEWS2. Conclusion. Treatment with baricitinib in addition to SOC was associated with reduced mortality and a lower prevalence of transfer to the ICU in hospitalized patients with COVID-19 pneumonia treated with high-flow oxygen non-invasive therapy.
The Impact of a Lockdown for the COVID-19 Pandemic on Seasonal HbA1c Variation in Patients with Type 2 Diabetes
Authors: Cheng Yu-Cheng , Li Yu-Hsuan , Liu Hsiu-Chen , Hsu Chiann-Yi , Chang Wan-Jen , Lee I-Te , Lu Chin-Li
Published: March 2023

Glycemic control in patients with type 2 diabetes may be disrupted due to restricted medical service access and lifestyle changes during COVID-19 lockdown period. This retrospective cohort study examined changes of HbA1c levels in adults with type 2 diabetes 12 weeks before and after May 19 in 2021, the date that COVID-19 lockdown began in Taiwan. The mean levels of HbA1c-after were significantly lower than HbA1c-before in 2019 (7.27 ± 1.27% vs 7.43 ± 1.38%, p < 0.001), 2020 (7.27 ± 1.28% vs 7.37 ± 1.34%, p < 0.001), and 2021 (7.03 ± 1.22% vs 7.17 ± 1.29%, p < 0.001). Considering the seasonal variation of HbA1c, ΔHbA1c values (HbA1c-after minus HbA1c-before) in 2020 (with sporadic COVID-19 cases and no lockdown) were not significantly different from 2021 (regression coefficient [95% CI] = 0.01% [−0.02%, 0.03%]), while seasonal HbA1c variation in 2019 (no COVID-19) was significantly more obvious than in 2021 (−0.05% [−0.07, −0.02%]). In conclusion, HbA1c level did not deteriorate after a lockdown measure during the COVID-19 pandemic in Taiwan. However, the absolute seasonal reduction in HbA1c was slightly less during the COVID-19 pandemic compared with the year without COVID-19.
Chitinase Is Involved in the Fruiting Body Development of Medicinal Fungus Cordyceps militaris
Authors: Zhang Zi-Juan , Yin Yuan-Yuan , Cui Yao , Zhang Yue-Xuan , Liu Bi-Yang , Ma You-Chu , Liu Yong-Nan , Liu Gao-Qiang
Published: March 2023

Cordyceps militaris is a famous traditional edible and medicinal fungus in Asia, and its fruiting body has rich medicinal value. The molecular mechanism of fruiting body development is still not well understood in C. militaris. In this study, phylogenetically analysis and protein domains prediction of the 14 putative chitinases were performed. The transcription level and enzyme activity of chitinase were significant increased during fruiting body development of C. militaris. Then, two chitinase genes (Chi1 and Chi4) were selected to construct gene silencing strain by RNA interference. When Chi1 and Chi4 genes were knockdown, the differentiation of the primordium was blocked, and the number of fruiting body was significantly decreased approximately by 50% compared to wild-type (WT) strain. The length of the single mature fruiting body was shortened by 27% and 38% in Chi1- and Chi4-silenced strains, respectively. In addition, the chitin content and cell wall thickness were significantly increased in Chi1- and Chi4-silenced strains. These results provide new insights into the biological functions of chitinase in fruiting body development of C. militaris.
Exercise Therapy in Nonspecific Low Back Pain among Individuals with Lower-Limb Amputation: A Systematic Review
Authors: Wnuk-Scardaccione Agnieszka , Zawojska Klaudia , Barłowska-Trybulec Marta , Mazur-Biały Agnieszka Irena
Published: March 2023

Low back pain is very common condition that often becomes a long-lasting problem in prostheses users after lower limb amputation. The presented study aims to decide the potential benefits of exercise therapy on low back pain among lower limb amputees by using a systematic review. The PICO technique was used to answer the primary issue of this review: Does exercise treatment lessen the prevalence of low back pain in the population of lower limb amputees? Systematic review was conducted in the following databases: Medline-PubMed, EMBASE, Scopus, and Web of Science. Studies up to September 2010 published in English are included. Aim, target population, development and execution strategies, and treatment suggestions were among the data gathered. The primary outcomes of interest were exercise interventions as a therapy for low back pain but only two articles met including criteria. The search was broadened and 21 studies describing biomechanical changes in gait and pelvic-spine posture were analysed. This review indicates that movement therapy is a potential treatment strategy in low back pain among amputees. The major limitation of the study is the very heterogenous group of subjects in terms of amputation level, baseline activity level and comorbidities. We used a procedure that was registered in PROSPERO (CRD42022345556) to perform this systematic review of systematic reviews. There is a necessity of good quality research for concluding a consensus of exercise intervention.
2-[2,6-Diisopropylphenyl]-4-phenyl-5H-5,9b[1′,2′]-benzonaphtho[1,2-b]pyrrol-2-ium Tetrafluoroborate
Authors: Tanaka Masaru , Kamiyama Shota , Ishii Akihiko , Nakata Norio
Published: March 2023

A novel α,β-unsaturated iminium salt (3) incorporated into a rigid dibenzobarrelene backbone was synthesized by heating N-(anthracen-9-ylmethyl)-2,6-diisopropylaniline (2) and 3-phenyl-2-propynal in THF in the presence of excess amounts of magnesium sulfate and 0.5 equivalents of an HBF4-Et2O complex. The molecular structure of 3 was characterized unambiguously by NMR spectroscopy and single-crystal X-ray diffraction (SCXRD) analyses. Compound 3 exhibits yellow luminescence in CH2Cl2 (λem = 516 nm) and in the solid state (λem = 517 nm) with relatively high to moderate quantum yields (ΦF(CH2Cl2) = 0.63; ΦF(solid) = 0.34).
New 2-(2,4-Dihydroxyphenyl)benzimidazolines
Authors: Stremski Yordan , Bachvarova Maria , Kirkova Desislava , Statkova-Abeghe Stela
Published: March 2023

New 2-(2,4-dihydroxyphenyl)benzimidazolines are synthesized in an easily accessible approach. The method is based on the reaction of resorcinol with in situ-formed electrophilic N-ethoxycarbonylbenzimidazolium reagents. The structure of the two newly formed products was spectrally characterized by 1D and 2D NMR, IR, and MS spectral analyses.
Synthesis of Bio-Based Polybenzoxazine and Its Antibiofilm and Anticorrosive Activities
Authors: Raorane Chaitany Jayprakash , Periyasamy Thirukumaran , Haldhar Rajesh , Asrafali Shakila Parveen , Raj Vinit , Kim Seong-Cheol
Published: March 2023

Candida albicans are highly widespread pathogenic fungi in humans. Moreover, its developed biofilm causes serious clinical problems, leading to drug failure caused by its inherent drug tolerance. Hence, the inhibition of biofilm formation and virulence characteristics provide other means of addressing infections. Polymer composites (PCs) derived from natural products have attracted increasing interest in the scientific community, including antimicrobial applications. PCs are a good alternative approach to solving this challenge because of their excellent penetration power inside biofilms. The main objectives of this study were to synthesize a novel curcumin-based polybenzoxazine polymer composite (poly(Cu-A) PC) using Mannich condensation reaction and evaluate their potency as an antibiofilm and anticorrosive candidate against C. albicans. In addition, their anticorrosive efficacy was also explored. PC exhibited significant antibiofilm efficacy versus C. albicans DAY185 by the morphologic changing of yeast to hyphae, and>90% anticorrosive efficacy was observed at a higher dose of PC. These prepared PC were safe in vivo against Caenorhabditis elegans and Raphanus raphanistrum. The study shows that a polybenzoxazine polymer composite has the potential for controlling biofilm-associated fungal infections and virulence by C. albicans, and opens a new avenue for designing PCs as antifungal, anticorrosive agents for biofilm-associated fungal infections and industrial remediation.
Deflection Test of Wire-Integrated Steel Deck Plates with Various End Details
Authors: Lee Hye-Ji , Yang Keun-Hyeok , Kim Sanghee , Hong Jong-Kook , Kim Deung-Hwan , Mun Ju-Hyun
Published: March 2023

This experimental study was conducted to evaluate the deflection performance of wire-integrated steel deck plates with various end details subjected to cumulative gravity loads. In general, when deck plates are installed in the Republic of Korea, vertical bars are mounted at the ends of the wire-integrated deck plates. However, this process can extend the construction time, thus incurring additional costs. Consequently, this study aimed to examine the structural performance of a deck plate when a lattice foot—rather than a vertical bar—is installed at the end of it. A total of nine specimens were prepared; the experimental variables included the end details, height of the lattice truss girder, and structure type. To evaluate the deflection performance, the cumulative gravity load (as a construction load) and a concrete self-weight were applied to the specimens, and the deflections of each specimen were measured. In the experimental results, the deflection values of the specimen with vertical bars were 0.9~6.1 mm, while those for the specimen without vertical bars were 0.8~5.0 mm. This means that a lattice foot exhibits better deflection performance than conventional end details. Additionally, the deflection of the specimens satisfied the deflection limits required in the relevant standards.
Traction-Associated Peridynamic Motion Equation and Its Verification in the Plane Stress and Fracture Problems
Authors: Yu Ming , Zhou Zeyuan , Huang Zaixing
Published: March 2023

How to prescribe traction on boundary surface is still an open question in peridynamics. This problem is investigated in this paper. Through introducing the induced body force defined by boundary traction, the Silling’s peridynamic motion equation is extended to a new formulation called the traction-associated peridynamic motion equation, which is verified to be compatible with the conservation laws of linear momentum and angular momentum. The energy conservation equation derived from the traction-associated peridynamic motion equation has the same form as that in the original peridynamics advanced by Silling. Therefore, the constitutive models of the original peridynamics can be directly applied to the traction-associated peridynamic motion equation. Some benchmark examples in the plane stress problems are calculated. The numerical solutions agree well with the classical elasticity solutions, and the volume correction and the surface correction are no longer needed in the numerical algorithm. These results show that the traction-associated peridynamic motion equation not only retains all advantages of the original peridynamics, but also can conveniently deal with the complex traction boundary conditions.
Microstructural Assessment, Mechanical and Corrosion Properties of a Mg-Sr Alloy Processed by Combined Severe Plastic Deformation
Authors: Nafikov Ruslan K. , Kulyasova Olga B. , Khudododova Ganjina D. , Enikeev Nariman A.
Published: March 2023

The development of high-performance biodegradable alloys with controllable corrosion rates to be used for manufacturing advanced implants is a hot topic of modern materials science and biomedicine. This work features the changes in microstructure, corrosion behavior and mechanical properties of the Mg-2 wt.%Sr alloy progressively induced by equal-channel angular pressing, high-pressure torsion and annealing. We show that such processing leads to significant microstructure refinement including diminishing grain size, defect accumulation and fragmentation of the initial eutectics. We demonstrate that the application of severe plastic deformation and heat treatment is capable of considerably enhancing the mechanical and corrosion performance of a biodegradable alloy of the Mg-Sr system. The best trade-off between strength, plasticity and the corrosion resistance has been achieved by annealing of the Mg-Sr alloy subjected to combined severe plastic deformation processing.
Microstructure and Dry/Wet Tribological Behaviors of 1% Cu-Alloyed Austempered Ductile Iron
Authors: Hsu Cheng-Hsun , Lin Chun-Yin , You Wei-Shih
Published: March 2023

In this study, different austempering conditions were applied to 1 wt.% Cu-alloyed ductile iron to produce various austempered ductile irons (ADIs). The study aimed to explore the variations in microstructure, hardness, and dry/wet wear behaviors of the ADIs. The experimental results indicated that the microstructure of the 300 °C–ADI has denser needle-like ausferrite, lower retained austenite content, and higher carbon content in austenite compared with the 360 °C–ADI. As the austempering time increased, the retained austenite content decreased, while the carbon content of austenite increased. Regardless of dry or wet abrasive behavior, the wear resistance of the ADIs was significantly superior to that of the as-cast material. The ADI obtained at 300 °C for 10 h demonstrated the best wear resistance performance.
Focusing on the Development and Current Status of Metamaterial Absorber by Bibliometric Analysis
Authors: Li Xin , Li Qiushi , Wu Liang , Xu Zongcheng , Yao Jianquan
Published: March 2023

In this paper, a total of 4770 effective documents about metamaterial absorbers were retrieved from the Web of Science Core Collection database. We scientifically analyzed the co-occurrence network of co-citation analysis by author, country/region, institutional, document, keywords co-occurrence, and the timeline of the clusters in the field of metamaterial absorber. Landy N. I.’s, with his cooperator et al., first experiment demonstrated a perfect metamaterial absorber microwave to absorb all incidents of radiation. From then on, a single-band absorber, dual-band absorber, triple-band absorber, multi-band absorber and broad-band absorber have been proposed and investigated widely. By integrating graphene and vanadium dioxide to the metamaterial absorber, the frequency-agile functionality can be realized. Tunable absorption will be very important in the future, especially metamaterial absorbers based on all-silicon. This paper provides a new research method to study and evaluate the performance of metamaterial absorbers. It can also help new researchers in the field of metamaterial absorbers to achieve the development of research content and to understand the recent progress.
Study on Shear Resistance Property of a New PBL Connector with Steel–Rubber Tenon
Authors: Lu Wenru , Li Donghui , Huang Yuanming , Wu Jun
Published: March 2023

In order to improve the shear resistance and structural ductility of the perfobond rib (PBL) connector, a new PBL connector with steel–rubber tenon is proposed in this study, which aims to increase the shear load capacity of the connector while improving the ductility of the connector. First, models of new PBLs are established based on the validated finite element method, and their mechanical properties are compared with other shear connectors. The results show that the stiffness and shear load capacity of the proposed connector can be effectively improved when the steel ring is added, where the shear stiffness can be reduced, and the deformation capacity of the specimen can be improved when the rubber ring is added. When a steel ring with a thickness of 5 mm and a rubber ring with a thickness of 5 mm are involved, the shear load capacity of the connector with steel–rubber tenon is increased by 13.7%, and the shear stiffness is reduced by 37.3% compared to the conventional concrete tenon connector, while the ductility is increased by 75.1% compared to the connector with steel ring tenon. Subsequently, as for the connectors with steel–rubber tenon, the effects of the thickness of the steel ring, the thickness of the rubber ring, the diameter of perforated rebar, the strength of concrete and the strength of perforated steel plate are analyzed based on the finite element model of a PBL. The results show that an increase in the thickness of the steel ring, the diameter of the perforated rebar and the strength of the concrete will cause an increase in the shear stiffness and shear load capacity of the connector; however, an increase in the thickness of the rubber ring can cause a decrease in the shear stiffness and shear load capacity of the connector, while a change in the strength of perforated steel plate has little effect on the shear stiffness and shear load-carrying capacity. Finally, based on the finite element parametric analysis results and the damage mechanism of the proposed connector, a calculation equation applicable to the PBL connector with steel–rubber tenon is presented to predict the shear load capacity of the connector.
Neutral Oil-Incorporated Liposomal Nanocarrier for Increased Skin Delivery of Ascorbic Acid
Authors: Ho Myoung Jin , Park Hyun Jin , Kang Myung Joo
Published: March 2023

In this study, a neutral oil-incorporated liposomal system (lipo-oil-some, LOS) was designed to improve the skin absorption of ascorbic acid (Vit C), and the effects of an edge activator and neutral oil on the skin absorption of Vit C were evaluated. As components of the LOS system, sodium deoxycholate, polysorbate 80, and cholesterol were screened as edge activators, and camellia oil, tricaprylin, and grapeseed oil were employed as neutral oils. The LOS systems prepared by the ethanol injection method were spherical in shape, 130–350 nm in size, and had 4–27% Vit C loading efficiency (%). In a skin absorption study using a Franz diffusion cell mounted with porcine skin, the LOS system prepared with sodium deoxycholate (10 w/w% of phospholipid) exhibited 1.2-and 2.9-fold higher absorption than those prepared with polysorbate 80 and cholesterol, respectively. Moreover, the type of neutral oil had a marked effect on the absorption of Vit C; the liposomal system containing camellia oil provided 1.3 to 1.8 times higher flux (45.4 μg/cm2∙h) than vesicles with tricaprylin or grapeseed oil, respectively. The optimized lipid nanocarrier is expected to be a promising tool for promoting the skin absorption of Vit C and improving its dermatological functions.
Foetal Intrapartum Compromise at Term: Could COVID-19 Infection Be Involved? A Case Report
Authors: Toma Adrian-Ioan , Hamoud Bashar Haj , Gavril-Parfene Caliopia , Farcaş Mihaela , Sima Romina-Marina , Ples Liana
Published: March 2023

The impact of the SARS-CoV-2 infection on pregnancy has been studied and many reports have been published, mainly focussing on complications and in utero transmission with neonatal consequences. Although the effects of other viruses on foetuses are well known, the impact of maternal COVID-19 during pregnancy is not completely understood. We report a case of acute foetal intrapartum hypoxia without other risk factors than maternal COVID-19 disease 2 weeks previous to birth at term. Placental histological changes suggested that the viral infection could have been the culprit for the unfavourable outcome during labour. The neonate was promptly delivered by Caesarean section. Neonatal intensive care was started, including therapeutic hypothermia. The procedure was successful, the evolution of the neonate was favourable, and she was discharged after 10 days. Follow-up at 2 months of life indicated a normal neurological development but a drop in head growth. The case raises the idea that pregnancies with even mild COVID-19 symptoms may represent the cause of neonate compromise in a low-risk pregnancy. An important follow-up in the neonatal period and infancy is required to identify and treat any subsequent conditions. Further long-term studies are necessary to identify a cause–effect relationship between COVID-19 pregnancies and the whole spectrum of neonatal and infant consequences.
The Performance of Ultrafiltration Process to Further Refine Lactic Acid from the Pre-Microfiltered Broth of Kitchen Waste Fermentation
Authors: Guo Yan , Li Chenglong , Zhao Hongjun , Wang Xiaona , Gao Ming , Sun Xiaohong , Wang Qunhui
Published: March 2023

Lactic acid (LA) is an important chemical material facing rapid demand in recent years. The oriented fermentation of kitchen waste is a promising route for economic LA production. However, the refinement of LA from fermentation broth is a spiny issue. In this study, the performance of ultrafiltration (UF) process for the refinement of LA from the pre-microfiltered broth of kitchen waste fermentation was first investigated. The results showed that with 50 KDa polyethersulfone membrane, under the optimum pressure of 120 KPa, the pH of 6.0, and the backflushing mode with the deionized water for 3 min, the best performance was achieved with the chroma removal efficiency, turbidity removal efficiency, protein removal efficiency and total sugar removal efficiency of 54.3%, 89.8%, 71.7% and 58.5%, respectively, and LA recovery efficiency was 93.6%. The results indicated that the UF process could further effectively refine the pre-microfiltered broth of kitchen waste fermentation, and the combination of microfiltration and UF process is ideal for achieving desirable LA refinement performance. This study verified the feasibility of UF process in LA refinement from pre-microfiltered broth of kitchen waste fermentation, and based on the results, the further exploration of proper post-process to treat UF filtrate for obtaining LA product with higher quality should be explored in the future.
Research on the Selective Electrocatalytic Reduction of SO2 to Recover S0 by Pb Electrode
Authors: Liu Xudong , Wang Xiaoyang , Long Jiaqi , Xie Xiaofeng , Wu Lin , Wang Zhujiang , Fu Yingxue , Chen Hao , Xiang Kaisong , Liu Hui
Published: March 2023

Resource utilization of SO2 from flue gas is a key challenge for the green development of the smelting industry. Recovery of sulfur resources in the form of elemental sulfur (S0), which has a high market demand and is a current focus in the field of SO2 treatment, can reduce the solid waste from desulfurization. In this study, it was found that Pb as a cathode material had good catalytic activity for the electrochemical reduction of SO2 and good selectivity towards elemental sulfur. However, the cathode suffers from sulfur poisoning. The problem was resolved by introducing surfactant, specifically sodium dodecyl benzene sulfonate (SDBS), which significantly lowered the sulfur content ratio on the surface of the electrode from 31.82% to 2.17%. Through the optimization of electrocatalytic parameters, this method enables efficient conversion of SO2 to S0, achieving a selectivity of 83% at pH = 0.25 and E = −0.8 V (vs. SCE).
Intermetallic Reaction of the Bonding Interface of TA2/Q235 Explosive Welding Composite
Authors: Zhou Qiang , Lu Honghong , Zhang Yudong , Guo Yansong , Zhu Lei , Huang Guangyan , Chen Pengwan
Published: March 2023

During the explosive welding, the bonding interface of welded materials was fast heated due to high strain rate and drastic plastic deformation. The periodical wave interface, with an amplitude of ~300 μm and a period wavelength of ~800 μm, was identifiable as a uniform wave interface formed in the bonding interface. The details of the formation of melting zone and mixing zone of welding materials at the interface were observed. Combined with the Ti-Fe binary phase diagram and the principle of diffusion welding, the phase composition and evolution process of the melting and mixing zone of the bonding interface were investigated by transmission electron microscopy (TEM) and energy dispersive spectrometer (EDS). Significance of the intermetallic compound was found in the mixing zone and melting zone, which was mainly TiFe, TiFe2, TiO2, Fe2O3 and some other intermetallic oxides. Meanwhile, the phenomenon of the titanium agglomeration and oxygen precipitation was observed in the melting zone. The bonding interface could be determined as a mixing welding of mechanical mixing, melting, diffusion and solidification that occurred in the mixing zone, and melting welding and diffusion welding mainly occurred in the melting region.
Instability Mechanism, Pressure Relief, and Long Anchorage Control Countermeasures for Surrounding Rock of Strong Mining Roadway at Large Mining Height Working Face
Authors: Qian Deyu , Jiao Hexi , Deng Jinping , Yang Jingxuan , Jiao Mingzhi , Xian Guihong , Yu Chenshi , Zhu Yingli , Liu Jiale , Huang Sen , Li Binyong
Published: March 2023

Double-roadway tunneling could mitigate the contradiction between mining production needs and tunneling speed, which is pivotal to the sustainable development of underground mines. However, it is very difficult to control the stability of a mining roadway on an adjacent working face suffering from strong mining disturbance due to double-roadway tunneling, especially at a large mining height working face. In order to control the stability of the return air roadway (RAR) 23205 of a strong mining roadway at working face 23205 in the Zhuanlongwan Coal Mine in Inner Mongolia, we carried out field monitoring, theoretical analysis, numerical simulations, and engineering practice to identify the main factors influencing the deformations and the stress distribution law of the surrounding rock in order to propose countermeasures for strong mining roadways. The results show the factors influencing the large deformation of strong mining roadways include large mining height, repeated mining, stress concentration due to the large coal pillar, and a small thickness of the anchorage layer in the roof. The stress peak in the central coal pillar caused by the first and second mining is 23.19 MPa and 27.49 MPa, respectively, and the stress concentration coefficients are 4.538 and 5.379, respectively. Countermeasures (pressure relief via large-diameter boreholes in the large coal pillar and long anchorage for roof reinforcement) were created to control the stability of a strong mining roadway, i.e., RAR 23205. Field measurements indicated that deformations in RAR 23205 could be efficiently controlled. The maximum deformation of the surrounding rock was 50 mm, which meets the safety and efficient production requirements of the coal mine. In addition, new roadway layout optimization and control countermeasures are put forward to control the stability of mining roadways.
Genesis and Fluid Evolution of the Hongqiling Sn-W Polymetallic Deposit in Hunan, South China: Constraints from Geology, Fluid Inclusion, and Stable Isotopes
Authors: Ren Wenqi , Wang Lei , Guan Shenjin , Xu Jiajin , He Hao , Zhu Enyi
Published: March 2023

The Hongqiling is a vein-type Sn-W polymetallic deposit in southern Hunan (South China). It is geologically located on the northern margin of the Nanling metallogenic belt. Based on the mineral assemblage and vein crosscutting relationship, three mineralization stages were identified: Sn-W mineralization (S1: cassiterite, wolframite, scheelite, arsenopyrite, molybdenite, pyrite, chalcopyrite, and quartz), Pb-Zn mineralization (S2: chalcopyrite, pyrrhotite, galena, sphalerite, pyrite, quartz, and fluorite), and late mineralization (S3: quartz, fluorite, calcite, galena, sphalerite, and pyrite). According to laser Raman probe analysis, H2O dominates the fluid inclusions in the S1 and S2 stage quartz, with CO2 and trace N2 following close behind. The ore fluid has low salinity, low density, and a wide temperature range, as per our microthermometric data: the S1 stage has homogenization temperatures (Th) of 236–377.6 °C (average 305.3 °C) and salinity of 3.5–10.7 wt.% NaCleqv; the S2 stage has Th of 206.5–332 °C (average 280.7 °C) and salinity of 1.6–5.1 wt.% NaCleqv; and the S3 stage has Th of 170.9–328.7 °C (average 246 °C) and salinity of 0.2–5.9 wt.% NaCleqv. Based on the results of the aforementioned investigation, the fluid inclusions in quartz, fluorite, and calcite are mainly H2O-NaCl vapor-liquid two-phase. Additionally, examinations of inclusions in S1 wolframite and coexisting quartz using infrared and microthermometry show that the mineralizing fluid likewise belongs to the NaCl-H2O system. The Th of inclusions in wolframite is ~40 °C higher than that of coexisting quartz. Moreover, the fluid experienced a decrease in temperature accompanied by nearly constant salinity, which indicates that wolframite precipitation is due to fluid mixing and simple cooling, and the precipitation is earlier than quartz. In situ S and H-O isotope data show that the samples have δ34S = −2.58‰ to 1.84‰, and the ore fluids have δD = −76.6 to −51.5‰ (S1 and S2), and δ18Ofluid = −6.6 to −0.9‰ (S1) and −12.9 to −10.2‰ (S2). All these indicate that the mineralizing fluid was derived from the granitic magma at Qianlishan, with substantial meteoric water incursion during the ore stage. Such fluid mixing and subsequent cooling are most likely the primary controls for ore deposition.
Microengineering Design for Advanced W-Based Bulk Materials with Improved Properties
Authors: Galatanu Magdalena , Enculescu Monica , Galatanu Andrei , Ticos Dorina , Dumitru Marius , Ticos Catalin
Published: March 2023

In fusion reactors, such as ITER or DEMO, the plasma used to generate nuclear reactions will reach temperatures that are an order of magnitude higher than in the Sun’s core. Although the plasma is not supposed to be in contact with the reactor walls, a large amount of heat generated by electromagnetic radiation, electrons and ions being expelled from the plasma will reach the plasma-facing surface of the reactor. Especially for the divertor part, high heat fluxes of up to 20 MW/m2 are expected even in normal operating conditions. An improvement in the plasma-facing material (which is, in the case of ITER, pure Tungsten, W) is desired at least in terms of both a higher recrystallization temperature and a lower brittle-to-ductile transition temperature. In the present work, we discuss three microengineering routes based on inclusions of nanometric dispersions, which are proposed to improve the W properties, and present the microstructural and thermophysical properties of the resulting W-based composites with such dispersions. The materials’ behavior after 6 MeV electron irradiation tests is also presented, and their further development is discussed.
Narrow UVB-Emitted YBO3 Phosphor Activated by Bi3+ and Gd3+ Co-Doping
Authors: Yu Zhimin , Yang Yang , Sun Jiaming
Published: March 2023

Y0.9(GdxBi1−x)0.1BO3 phosphors (x = 0, 0.2, 0.4, 0.6, 0.8, and 1.0, YGB) were obtained via high-temperature solid-state synthesis. Differentiated phases and micro-morphologies were determined by adjusting the synthesis temperature and the activator content of Gd3+ ions, verifying the hexagonal phase with an average size of ~200 nm. Strong photon emissions were revealed under both ultraviolet and visible radiation, and the effectiveness of energy transfer from Bi3+ to Gd3+ ions was confirmed to improve the narrow-band ultraviolet-B (UVB) (6PJ→8S7/2) emission of Gd3+ ions. The optimal emission was obtained from Y0.9Gd0.08Bi0.02BO3 phosphor annealed at 800 °C, for which maximum quantum yields (QYs) can reach 24.75% and 1.33% under 273 nm and 532 nm excitations, respectively. The optimal QY from the Gd3+-Bi3+ co-doped YGB phosphor is 75 times the single Gd3+-doped one, illustrating that these UVB luminescent phosphors based on co-doped YBO3 orthoborates possess bright UVB emissions and good excitability under the excitation of different wavelengths. Efficient photon conversion and intense UVB emissions indicate that the multifunctional Gd3+-Bi3+ co-doped YBO3 orthoborate is a potential candidate for skin treatment.
Facile Synthesis of the Polyaniline@Waste Cellulosic Nanocomposite for the Efficient Decontamination of Copper(II) and Phenol from Wastewater
Authors: Doyo Ahmed N. , Kumar Rajeev , Barakat Mohamed A.
Published: March 2023

The existence of heavy metals and organic pollutants in wastewater is a threat to the ecosystem and a challenge for researchers to remove using common technology. Herein, a facile one-step in situ oxidative polymerization synthesis method has been used to fabricate polyaniline@waste cellulosic nanocomposite adsornt, polyaniline-embedded waste tissue paper (PANI@WTP) to remove copper(II) and phenol from the aqueous solution. The structural and surface properties of the synthesized materials were examined by XRD, FTIR, TEM, and a zeta potential analyzer. The scavenging of the Cu(II) and phenol onto the prepared materials was investigated as a function of interaction time, pollutant concentration, and solution pH. Advanced kinetics and isotherms modeling is used to explore the Cu(II) ion and phenol adsorption mechanisms. The synthesized PANI@WTP adsorbent showed a high intake capacity for Cu(II) than phenol, with the maximum calculated adsorption capacity of 605.20 and 501.23 mg g−1, respectively. The Langmuir equilibrium isotherm model is well-fitted for Cu(II) and phenol adsorption onto the PANI@WTP. The superior scavenging capability of the PANI@WTP for Cu(II) and phenol could be explained based on the host–guest interaction forces and large active sites. Moreover, the efficiency of the PANI@WTP for Cu(II) and phenol scavenging was excellent even after the five cycles of regeneration.
Nitrogen Adsorption and Characteristics of Iron, Cobalt, and Nickel Oxides Impregnated on SBA-15 Mesoporous Silica
Authors: Tsai Jiun-Horng , Lee Ting-Yi , Chiang Hung-Lung
Published: March 2023

Hexagonal SBA-15 mesoporous material was used as a catalytic template for impregnation, with the transition metals Fe, Co, and Ni as catalysts for chemical transformation. Nitrogen adsorption/desorption isotherms, scanning electron microscopy, and transmission electron microscopy were conducted to better understand the physicochemical properties of the metal oxide-impregnated SBA-15. The specific surface area of the original SBA-15 was approximately 680 m2/g, and the abundances of the catalysts impregnated ranged from 2 to 8%, corresponding to specific surface areas of 560–470 m2/g for Fe-SBA-15, 440–340 m2/g for Ni-SBA-15, and 410–340 m2/g for Co-SBA-15. The increase in impregnated metal loadings filled the pores and collapsed the silica walls during the metal oxides impregnation on SBA-15 and calcination procedures, resulting in a decrease in the specific surface area and pore volume of the templates. The results showed that the order of nitrogen adsorbed was SBA-15 > Fe-SBA-15 > Ni-SBA-15 > Co-SBA-15 when the metal loading was 5%. In addition, the metal oxides on SBA-15 increased the wall thickness compared with raw SBA-15. Based on the XRD spectrum analysis, Fe2O3, Co3O4, and NiO were the stable crystals on the Fe-SBA-15, Co-SBA-15, and Ni-SBA-15, respectively. The sequence of the average grain size of metal oxides on SBA-15 was Co-SBA-15 > Fe-SBA-15 > Ni-SBA-15, according to XRD spectra and Scherrer’s equation. Isopropanol could be decomposed by metal oxide-impregnated SBA-15 to form carbon filament materials. Therefore, these materials have the potential to be employed for pollutant removal, catalytic reactions for organic solvent and bio-oil/biomass reforming, and recycling waste into high-value materials.