bluuebunny/crossref_metadata_2025 huggingface dataset:
Social Exclusion and Impulsive Buying among Chinese College Students: The Mediating Role of Self-Esteem and The Moderating Role of Risk Preference
Authors: Luo Haocheng , Chen Jiarong , Li Shengnan , Nie Yangang , Wang Guodong
Published: September 2021

With the development of science and technology, buying has become much easier. At the same time, however, impulsive buying has many negative consequences for college students, and the causes of impulsive buying should therefore be explored. To explore the relationship between social exclusion and impulsive buying and its underlying mechanism, this study used the Social Exclusion Scale, Self-Esteem Scale, Risk Preference Scale, and Impulsive Buying Scale to investigate the roles of self-esteem and risk preference in the relationship between social exclusion and impulsive buying among 768 college students (387 were female, Mage = 20.25 years). The results were as follows: (1) when controlling for gender, age, family monthly income, and monthly living expenses, social exclusion significantly and positively predicted impulsive buying; (2) self-esteem played a mediating role between social exclusion and impulsive buying; (3) risk preference moderated the relationship between the second half of the mediating path and the direct path. These results reveal the mechanism underlying impulsive buying in college students, that is, social exclusion will predict the decrease of college students' self-esteem, and low self-esteem will further predict college students' impulsive buying which is a way for them to gain a sense of self-worth. Relatively low risk preference can well alleviate the negative impact of social exclusion and low self-esteem on impulsive buying. What’s more, these results have implications for impulsive buying interventions. Schools should aim to create a good peer atmosphere by making certain rules that help to reduce social exclusion and parents and education departments should cultivate students’ risk awareness to avoid risk behaviors in college students, such as impulsive buying behavior.
Microclimatic Effects on the Preservation of Finds in the Visitor Centre of the Archaelological Site 1a Imperial Palace Sirmium
Authors: Ugrinović Aleksandra , Sudimac Budimir , Savković Željko
Published: September 2021

For the purpose of this paper, the actual air temperature and air humidity values were monitored in the Visitor Centre of the Archaeological site 1a Imperial Palace Sirmium, designated cultural heritage of exceptional importance. The contamination level of archaeological finds in the site was microbiologically analysed. The findings showed that during the phase of microclimatic monitoring (February–April 2021), air humidity was almost constantly above the levels set by standards and recommendations for museum collections (>60%). The highest levels of air humidity, amounting to 93%, were recorded in February, with daily oscillations of up to 30%; the lowest recorded temperature was 0.3°C, with the maximum daily oscillations of 6°C. Microbiological analysis revealed great diversity in the deterioration level of the finds, which can be attributed to the time lapse between the last conservation and the present. The comparative analysis of microclimatic monitoring and microbiological analysis results identified high levels of relative air humidity as the dominant factor in the increased microbiological contamination of the finds. The findings also pointed to the necessity of continuous microclimatic monitoring during the actual usage of the facility in order to provide the sustainable display and preservation of the finds on the premises.
Epigenetic Programming of Cancer-Related Inflammation byncRNA Rheostat: Impact on Tumor Directed Immune Therapies
Authors: Roy Roshan , Sharma Uttam , Yadav Rakhi , Rana Manjit Kaur , Sharma Ashok , Tanwar Pranay , Jain Aklank , Prakash Hridayesh
Published: September 2021

Accumulating evidences demonstrate that the host genome's epigenetic modificationsare essential for living organisms to adapt extreme conditions.DNA methylation, covalent modifications of histone, andinter-association of non-coding RNAs facilitate the cellular manifestation ofepigenetic changes in the genome. Out of various factors involved in the epigenetic programming of the host, miRNA (microRNA) and LncRNA (Long non-coding RNA) are new generationnon-coding molecules that influence a variety of cellular processes like immunity, cellular differentiation, and tumor development. During tumor development, temporal changes in miRNA/LncRNA rheostat influence sterile inflammatory responses accompanied by the changes in the carcinogenic signalling in the host. At the cellular level, this is manifested by the up-regulation of Inflammasome and inflammatory pathways, which promotes cancer-related inflammation. In view of this, we discuss the potential of lncRNA and miRNA directed interventions in regulating inflammation and tumor development in the host.
Anthropogenic and Environmental Strain on Beach Environments Retrieved and Monitored by Spaceborne Synthetic Aperture Radar
Authors: Di Biase Valeria , Hanssen Ramon F.
Published: September 2021

Environmental effects and climate change are lately representing an increasing strain of the coastal areas which topography strongly depends on these conditions. However, the processes by which weather and environmental phenomena influence the highly variable beach morphology are still unknown. A continuous monitoring of the beach environment is necessary to implement protection strategies. This paper presents the results of an innovative study performed on a coastal area using satellite remote sensing data with the aim of understanding how environmental phenomena affect beaches. Two-years of synthetic aperture radar (SAR) Sentinel-1 images are used over a test area in Noordwijk, the Netherlands. At the same time as the SAR acquisitions, information on tidal and weather conditions are collected and integrated from nearby meteorological stations. Dedicated codes are implemented in order to understand the relationship between the SAR amplitude and the considered phenomena: wind, precipitation, tidal conditions. Surface roughness is taken into account. The results indicate a strong correlation between the amplitude and the wind. No particular correlation or trend could be noticed in the relation with the precipitation. The analysis of the amplitude also shows a decreasing trend moving from the dry area of the beach towards the sea and the correlation coefficient between the amplitude and the tide level gets negative with the increase of the water content.
Microbial Biosurfactant: A New Frontier for Sustainable Agriculture and Pharmaceutical Industries
Authors: Kumar Ajay , Singh Sandeep Kumar , Kant Chandra , Verma Hariom , Kant Chandra , Singh Prem Pratap , Modi Arpan , Droby Samir , Kesawat Mahipal Singh , Alavilli Hemasundar , Bhatia Shashi Kant , Saratale Ganesh Dattatraya , Saratale Rijuta Ganesh , Chung Sang-Min , Kumar Manu
Published: September 2021

In the current scenario of changing climatic conditions and rising global population, there is always a need to explore novel, efficient, and economical natural products for the benefit of human kind. Biosurfactant is one of the latest explored microbial biomolecules that have been used in numerous fields, including agriculture, pharmaceuticals, cosmetics, food processing, and environment-cleaning industries as raw material, lubrication, wetting, foaming softening, making emulsions, and stabilizing dispersions. The amphiphilic nature of biosurfactant biomolecules showed great advantage, distributing themselves into two immiscible surfaces by reducing interfacial surface tension and increasing the solubility of hydrophobic compounds. Furthermore, their eco-friendly nature, low or even no toxic nature, durability at higher temperatures, and wide range of pH fluctuations making the microbial surfactants preferable compared to their chemical counterparts. Additionally, the biosurfactants can obviate the oxidation flow by eliciting the antioxidant property, antimicrobial, anticancer activity, and drug delivery system, further broadening their applicability in the food, pharmaceutical, and pharma industries. Nowadays, biosurfactant has been broadly utilized to improve the soil quality by improving the concentration of trace elements and mixed with pesticides or applied singly on the plant surfaces for plant disease management. In the present review, we summarise the latest aspect of microbial synthesized biosurfactant compounds, limiting factors of biosurfactant production, and their application in improving soil quality, plant disease management.
Physical Exercise and the Prosocial Behaviors of Students in China
Authors: Wan Yi , Lv Lian , Song Hong lian
Published: September 2021

Based on the 2014-2015 China Education Panel Survey (CEPS) and using the propensity score matching method, we studied the causal relationship between physical exercise and prosocial behavior of junior middle school students in China. Ordinary least squares regression and propensity score matching estimation results showed that participation in physical exercise significantly increases students’ prosocial behavior by more than 0.2 standard points. The results of this study were tested and found to be robust.
Dynamics of Serum Thymidine Kinase 1 at the First Cycle of Neoadjuvant Chemotherapy Predicts Outcome of Disease in Estrogen-receptor-positive Breast Cancer
Authors: Tribukait Bernhard
Published: September 2021

Complete pathologic response (pCR) predicts the long-term outcome of neoadjuvant treated (NAC) breast cancer (BC) but is reached in <10% of hormone-receptor-positive patients. Biomarkers able to guide adjustment or interruption of an ineffective therapy are desired. Here, we evaluated whether shifts in the serum concentration of thymidine kinase 1 (sTK1) during NAC could be utilized as a biomarker. In the PROMIX trial, women with localized HER2- BC received neoadjuvant epirubicin/docetaxel in six cycles. sTK1 was measured with an ELISA in 54 patients at cycles 1-4 and in a total of 131 patients before and 48h after cycle 1. The prognostic significance of the results was evaluated by log-rank tests of Kaplan–Meier estimates. Treatment resulted in a 2-fold increase of sTK1 before and 3-fold increase 48h after the cycles, except for the first cycle, where half of patients reacted with a decrease (post/pre sTK1- ratio <1.12) and the other half reacted with an increase (ratio >1.12). OS rates in ER+ patients with ratios of >1.12 and <1.12 were 97.7% and 78% (p=0.005), respectively, and DFS rates were 90.7% and 68% (p=0.006), respectively. Thus, response of sTK1 at the first cycle of chemotherapy could be used both as an early biomarker for guidance of chemotherapy and for the study of inherent tumor chemo-sensitivity, which could predict long-term outcome prior to therapy.
Using Non-Fourier’s Heat Flux and Non-Fick’s Mass Flux Theory in the Radiative and Chemically Reactive Flow of Powell-Eyring Fluid
Authors: Firdous Hina , Saeed Syed Tauseef , Ahmed Hijaz , Husnine Syed Muhammad
Published: September 2021

The behavior of convective boundary conditions is studied to delineate their role in heat and mass relegation in the presence of radiation, chemical reaction, and hydromagnetic forces in three-dimensional Powell-Eyring nanofluids. Implications concerning non-Fourier’s heat flux and non-Fick’s mass flux with respect to temperature nanoparticle concentration were examined to discuss the graphical attributes of the principal parameters. An efficient optimal homotopy analysis method is used to solve the transformed partial differential equations. Tables and graphs are physically interpreted for significant parameters
PERAN SENTRA INDUSTRI GERABAH MELIKAN DALAM PENGEMBANGAN KAWASAN PARIWISATA
Authors: Sundoro Gogor Aldi , Miladan Nur , Pamardhi-Utomo Rizon
Published: September 2021

Pariwisata menjadi strategi yang telah banyak diterapkan untuk meningkatkan nilai tambah sentra industri rumah tangga. Pemerintah Kabupaten Klaten juga menggunakan strategi tersebut dalam mengembangkan sektor industri rumah tangganya. Sentra Industri Gerabah Melikan merupakan salah satu sektor industri di Kabupaten Klaten yang diterapkan menjadi kawasan pariwisata. Kegiatan wisata di Sentra Industri Gerabah Melikan tidak lepas dari permasalahan, seperti permasalahan terkait fasilitas sentra yang kurang mendukung kegiatan wisata. Berdasarkan masalah tersebut, penelitian ini bertujuan untuk mengetahui komponen kesesuaian fasilitas kawasan Sentra Industri Melikan berdasarkan indikator kawasan pariwisata. Metode pendekatan yang digunakan dalam penelitian ini, yaitu pendekatan kuantitatif, sedangkan analisis yang digunakan merupakan analisis skoring. Pengumpulan data dilakukan dengan cara observasi, kuesioner, dan wawancara. Pembahasan komponen fasilitas sentra industri pada penelitian ini meliputi, area pembuatan gerabah wisata, area terdampak  tungku pembakaran, ketersediaan jalan kawasan, jangkauan parkir wisata, ketersediaan tempat sampah kawasan, ketersediaan listrik kawasan, dan kualitas air bersih kawasan. Hasil dari penelitian ini menunjukkan bahwa fasilitas Sentra Industri Gerabah Melikan memiliki kesesuaian sedang dengan nilai 2,2 poin dari rentang 1-3 poin. Berdasarkan hasil tersebut dapat disimpulkan bahwa, fasilitas secara keseluruhan yang menjadi objek penelitian ini masih kurang mampu dalam mendukung Sentra Industri Gerabah Melikan sebagai kawasan pariwisata.
ARCHITECTURE OF MALTA’S STRUCTURES
Authors:   Krakowska Akademia im. A.F. Modrzewskiego Wydział Architektury i Sztuk Pięknych, Kurek Jan
Published: September 2021

Stone buildings appeared on Malta over 7000 years ago – around 3500 BC. Impressive megalithic structures were built at the time. Similar stone structures were erected in many places throughout Europe. Large megalithic structures have survived on Malta in areas such as Ġgantija and Tarxien. In other areas, large spaces called hypogea were carved from rock. Both in prehistory and today, stone remains one of the primary construction materials used across the Maltese archipelago. The architectural forms of seaside resorts are now cosmopolitan. Few contemporary projects reference historical building traditions – both formal and material.
THE IDENTITY IMPORTANCE IN SHAPING SELECTED, NEW URBAN SPACES IN WARSAW, PRAGA – PÓŁNOC
Authors:   Warsaw University of Technology Faculty of Geodesy and Cartography Department of Spatial Management and Environmental Sciences, Jarecka-Bidzińska Ewa , Denis Małgorzata ,   Warsaw University of Technology Faculty of Geodesy and Cartography Department of Spatial Management and Environmental Sciences
Published: September 2021

The article analyzes how selected important public places in Praga-Północ have developed throughout history and how, in the face of today's economic, functional and spatial conditions as well as socio-cultural needs, create inclusive, resident-friendly urban spaces that build a positive image of the district. The authors will attempt to present proposal for system of interconnected public spaces based on the potential of the place. The model of connections, the proposed system of urban spaces in Praga-Północ is based on many years of researches in situ.
LIMITED SPACE FOR TREES IN THE URBAN PLANNING OF THE CITY (ON THE EXAMPLE OF SELECTED LOCATIONS IN SZCZECIN AND GOLENIÓW)
Authors:   West Pomeranian University of Technology in Szczecin Faculty of Environmental Management and Agriculture Chair of Landscape Architecture, Nowak Paweł
Published: September 2021

This paper presents a study on the introduction of trees into urban space after 1960 on the example of Szczecin and Goleniów, Selected area types located in downtown areas such as: front gardens, greenery strips along streets, and trees lining streets, were observed over a period of five years and analysed. This paper is also intended to present the significant problem of trees dying in downtown areas. Current methods of alleviating the difficult situation of trees in the city were also presented.
REVITALIZATION OF THE AREA OF FORT III GRAF KIRCHBACH AS AN ELEMENT OF RESPONSIBLE URBANIZATION OF THE CITY OF POZNAŃ
Authors:   Politechnika Poznańska Wydział Architektury Instytut Architektury i Planowania Przestrzennego, Piklikiewicz-Kęsicka Izabela
Published: September 2021

The paper aim is to examine urban and spatial possibilities of the Poznań Fort III area in the context of the implementation of the city's spacial policy. Urbanisation based on executing new facilities and investments results in the creation of diverse urban landscape. This contrast concerns not only the visual perception, but also also uneven use of different parts of the city. The aim of the study is to present a strategy for the revitalisation of the Fort Graf Kirchbach in the accordance with the principles of responsible urbanisation.
THE HISTORY OF THE OLD TOWN HALL IN SIERADZ
Authors:   Assistant Designer Municipal Planning Office in Łódź, Sowała Adriana
Published: September 2021

The Old Town in Sieradz is one of the oldest and best-preserved medieval urban complexes in Poland. In its center there is the Old Market Square, which was marked out at the intersection of important trade routes in the 13th century. Unfortunately, to this day, the center-market buildings, including the town hall, have not been preserved. Moreover, no photo or drawing showing the appearance of the Sieradz seat of municipal authorities has survived. In connection with the above, the article attempts to present the history of the repeatedly rebuilt town hall in Sieradz from different periods, as well as plans for its reconstruction. For this purpose, the available archival materials, the results of archaeological research and the literature on the subject were used, the analysis of which allowed to draw conclusions about the history of the town hall in Sieradz.
Work Redesign for the 21st Century: Promising Strategies for Enhancing Worker Well-Being
Authors: Lovejoy Meg , Kelly Erin L. , Kubzansky Laura D. , Berkman Lisa F.
Published: September 2021

Work is a key social determinant of population health and well-being. Yet, efforts to improve worker well-being in the United States are often focused on changing individual health behaviors via employer wellness programs. The COVID-19 health crisis has brought into sharp relief some of the limitations of current approaches, revealing structural conditions that heighten the vulnerability of workers and their families to physical and psychosocial stressors.

To address these gaps, we build on existing frameworks and work redesign research to propose a model of work redesign updated for the 21st century that identifies strategies to reshape work conditions that are a root cause of stress-related health problems. These strategies include increasing worker schedule control and voice, moderating job demands, and providing training and employer support aimed at enhancing social relations at work.

We conclude that work redesign offers new and viable directions for improving worker well-being and that guidance from federal and state governments could encourage the adoption and effective implementation of such initiatives. (Am J Public Health. 2021;111(10):1787–1795. https://doi.org/10.2105/AJPH.2021.306283 )
The Feasibility of Ultrasound-Guided Knee Arthrocentesis Training Using Formalin-Embalmed Cadavers
Authors: Clason Joshua , Liederbach Margaret , Balkman Nathan , Davis Edwin , Zapata Isain , Mason Nena Lundgreen
Published: September 2021

Background:

The use of ultrasound guidance during knee arthrocentesis has proven to increase operator confidence and accuracy, particularly in novice healthcare providers. Realistic and practical means of teaching this procedure to medical trainees are needed. This study is intended to assess the feasibility and efficacy of using formalin-embalmed human cadavers in the instruction of ultrasound-guided knee arthrocentesis to medical trainees.

Methods:

Twenty participants received a 30-minute didactic orientation detailing the principles of ultrasound-guided knee arthrocentesis, followed by a training practicum performed on human cadavers. The practicum included a 25-minute training period, followed by a 15-minute assessment period. Participants were objectively assessed on their ability to independently aspirate synovial fluid from the suprapatellar bursa using ultrasound guidance. Digital pretraining and posttraining questionnaires were administered to evaluate each participant’s confidence in their ability to independently locate the site of optimal needle placement and successfully aspirate synovial fluid with the guidance of ultrasound imaging.

Results:

An analysis via the Wilcoxon rank sum testing revealed that participant self-confidence increased significantly after training across all assessment items (p < 0.0001). Fifteen participants (75%) successfully aspirated 1 mL of synovial fluid on their first attempt, whereas 3 participants (15%) were successful on their second attempt. Two participants (10%) failed to perform a successful aspiration within the 15-minute time limit. The average time required to aspirate 1 mL of synovial fluid was 41 seconds.

Conclusions:

Ultrasound images of the formalin-embalmed suprapatellar bursa are of sufficient quality to use in the instruction of arthrocentesis to medical trainees. Brief instruction using formalin-embalmed cadaver models significantly increases trainee confidence and prepares first-year medical students to successfully and independently perform ultrasound-guided knee arthrocentesis.
Computer-Assisted Preoperative Planning and Patient-Specific Instrumentation for Glenoid Implants in Shoulder Arthroplasty
Authors: Levins James G. , Kukreja Mohit , Paxton E. Scott , Green Andrew
Published: September 2021

» Glenoid component positioning affects implant survival after total shoulder arthroplasty, and accurate glenoid-component positioning is an important technical aspect.

» The use of virtual planning and patient-specific instrumentation has been shown to produce reliable implant placement in the laboratory and in some clinical studies.

» Currently available preoperative planning software programs employ different techniques to generate 3-dimensional models and produce anatomic measurements potentially affecting clinical decisions.

» There are no published data, to our knowledge, on the effect of preoperative computer planning and patient-specific instrumentation on long-term clinical outcomes.
The Knowledge Of Reproductive Health With Adolescent Behavior In Soe Christian Vocational School 2019
Authors: Ertiana Dwi , Ottu Alisa
Published: September 2021

Technological advances have both positive and negative impacts on adolescents, especially in dating behavior. Dating behavior has the same meaning as the knowledge of the pros and cons. The problem faced by adolescents today is the large number of promiscuity, so they must have a positive attitude in dating behavior in order to avoid negative thoughts from the dating behavior. This study aims to determine the relationship between knowledge of reproductive health and dating behavior of adolescents at SMK Kristen Soe. The design of this research is correlational analytic with cross sectional approach. The population was 44 students in class XI Software Engineering who were taken by simple random sampling technique by paying attention to the inclusion criteria (students willing to become respondents and dating) and exclusion criteria (students not attending the research), so that a sample of 31 respondents was obtained. . Data collection was carried out on May 13-24 2019. Data collection used a questionnaire. The results showed that from 31 respondents got information about knowledge of reproductive health and dating behavior, namely 29 respondents (94%) and had good knowledge, namely 18 respondents (58.1%) and had healthy dating behavior, namely 23 respondents (74.2%) . The results of the analysis used the Spearman Rank test with p-value = 0.000 ˂ ɑ = 0.05 with a value of C = 0.771. Knowledge can also influence a person's behavior. Through his knowledge, a person will tend to agree on various things according to the object of behavior.
Geophysical investigation to assess condition of grouted scour hole : Old River Control Complex—Low Sill Concordia Parish, Louisiana
Authors: Simms Janet , Breland Benjamin , Doll William
Published: September 2021

Geophysical surveys, both land-based and water-borne, were conducted at the Old River Control Complex‒Low Sill, Concordia Parish, LA. The purpose of the surveys was to assess the condition of the grout within the scour region resulting from the 1973 flood event, including identification of potential voids within the grout. Information from the ground studies will also be used for calibration of subsequent marine geophysical data and used in stability analysis studies. The water-borne survey consisted of towed low frequency (16-80 MHz) ground penetrating radar (GPR), whereas the land-based surveys used electrical resistivity and seismic refraction. The GPR survey was conducted in the Old River Channel on the upstream side of the Low Sill structure. The high electrical conductivity of the water (~50 mS/m) precluded penetration of the GPR signal; thus, no useful data were obtained. The land-based surveys were performed on both northeast and southeast sides of the Low Sill structure. Both resistivity and seismic surveys identify a layered subsurface stratigraphy that corresponds, in general, with available borehole data and constructed geologic profiles. In addition, an anomalous area on the southeast side was identified that warrants future investigation and monitoring.
Stay Home Save Lives: A Machine Learning Approach to Causal Inference to Evaluate Impact of Social Distancing in the US
Authors: Osman Syed Muhammad Ishraque , Sakib Nazmus
Published: September 2021

Introduction: This study presents a machine learning based evaluation of the social distancing measures implemented in the US states. Objectives: Although there are a few studies that provide estimations of the impact of COVID-19 pandemic, there is a need for an actual policy evaluation of the already implemented social distancing measures. This paper presents an evaluation of the social distancing measures implemented by the US states. Methods: This research uses a machine learning based Generalized Synthetic Control Method. In doing so, it considers the US states that adopted early social distancing approaches as the treatment group and the states that adopted social distancing much later as the control group and it has controlled for state and time fixed effects, to cancel out the possible selection bias and endogeneity. Results: The results show that the first round of social distancing in the US is associated with lower COVID-19 infection growth rate (by -167%) when compared to the no policy intervention counterfactual. Conclusions: The findings from this policy evaluation establishes a robust scientific basis of the efficacy of social distancing measures on slowing down the contagion of a pandemic.
Hsa_circ_0000839 Inhibits Papillary Thyroid Carcinoma Proliferation by Targeting CDC27
Authors: Guo Jiahui , Liu Tingting , Shan Zhongyan , Teng Weiping
Published: September 2021

Background: Circular RNA (circRNA) has been reported to play multiple roles in a variety of cancers. However, the role of circRNA in papillary thyroid carcinoma (PTC) remains mostly unknown. Methods: The expression, function and potential molecular mechanisms of hsa_circ_0000839 in PTC in vitro were evaluated by quantitative RT-PCR, western blot, flow cytometry, CCK8, Edu, RNA-sequencing, luciferase reporter, and RNA immunoprecipitation assay. The function of hsa_circ_0000839 in PTC in vivo was evaluated by xenograft tumors assay.Results: Hsa_circ_0000839 was significantly downregulated in PTC tissues and plasma from patients with PTC, and its downregulation was correlated with larger tumor size in patients with PTC. The role of hsa_circ_0000839 in the proliferation of PTC cell lines was evaluated in both vitro and in vivo. Mechanistically, hsa_circ_0000839 regulated the level of CDC27 via sponging miR-149-5p in PTC. Conclusions: Hsa_circ_0000839 might act as a tumor suppressor of PTC through the hsa_circ_0000839/miR-149-5p/CDC27 axis. Hsa_circ_0000839 could serve as a potential biomarker and therapeutic target for patients with PTC.
Feasibility of a Multimodal Prehabilitation Program in Patients Undergoing Cytoreductive Surgery for Advanced Ovarian Cancer: a Pilot Study
Authors: Díaz-Feijóo Berta , Agustí Nuria , Sebio Raquel , López-Hernández Antonio , Sisó Marina , Torné Aureli , Martinez-Palli Graciela , Arguis Maria J
Published: September 2021

Purpose The feasibility and effects of multimodal prehabilitation in patients with advanced ovarian cancer (AOC) undergoing a cytoreductive surgery are unknown. We aimed to evaluate the feasibility of a multimodal prehabilitation program in patients with AOC and its impact on postoperative outcomes.Methods We prospectively compared 15 patients with AOC stage scheduled to undergo a citorreductive surgery between December 2019 and January 2021 after a multimodal prehabilitation program consisting of supervised exercise training, nutritional optimization and psychological preparation versus a control cohort of 19 patients matched according to clinical and surgical characteristics who underwent surgery without prehabilitation between January 2018 and November 2019. In both groups, the enhanced recovery after surgery guidelines were followed. We analyzed adherence to the program, comprehensive complication index (CCI), hospital length of stay, and time to starting chemotherapy. Results Overall adherence to the multimodal prehabilitation program was 80%, with 86.7% adherence to exercise training, 100% adherence to nutritional optimization, and 80% adherence to psychological preparation. Median hospital stay was shorter in the prehabilitation cohort [5 days (IQR, 4-6) vs. 7 days (IQR,5-9) in the control cohort, p=0.04]. CCI score in the prehabilitation cohort was 9.3 (SD 12.12) vs. 16.61 (SD 16.89) in the control cohort, p=0.2. Median time to starting chemotherapy was shorter in the prehabilitation cohort compared to control cohort [25 days (IQR, 23-25) vs. 35 days (IQR 28-45), p=0.03]. Conclusion Multimodal prehabilitation is feasible and safe in patients with AOC. This study found significantly shorter hospital stays and time to starting chemotherapy in the multimodal prehabilitation cohort.
Disseminated Salmonellosis in a child with IL12Rß1 deficiency – Case report and review of literature.
Authors: Mohite Rachna Shanbhag , Gangulappa Rajeshwari Kempireddygaripalli , Narasimhamurthy Vidya Manur , Bhattad Sagar
Published: September 2021

Mendelian susceptibility to mycobacterial disease (MSMD) is a group of genetic disorders characterized by a defect in interferon γ (IFN γ)–mediated immunity, with predisposition to infections caused by atypical and low virulent mycobacteria and other intra-macrophagic organisms like Salmonella, Klebsiella, Listeria etc. A 10-year-old boy, second born of a consanguineously (third-degree) married Indian couple, presented with left inguinal and submandibular lymphadenopathy with low grade fever for 10 days. Past history was significant as the child had been unwell from infancy. At the age of 4 months and 5 years, he was diagnosed to have tubercular axillary lymphadenitis and was treated with anti-tubercular drugs on each occasion and he responded to the same. On examination, he had left submandibular and inguinal lymphadenopathy and mild splenomegaly. Chest radiograph showed enlarged mediastinal nodes. He underwent left inguinal lymph node biopsy that reported granulomatous lymphadenitis. However, culture from the biopsy showed a growth of Salmonella enterica sensitive to ceftriaxone. Genetic evaluation showed pathogenic homozygous mutation c.1791 + 2T > G in exon 15 of IL12Rß1 gene by whole exome sequencing. A diagnosis of Mendelian Susceptibility to Mycobacterial Disease (MSMD) was established and he was treated with intravenous ceftriaxone followed by oral cefixime. He responded promptly and lymphadenopathy resolved. He is currently being maintained on azithromycin prophylaxis. Children and adults presenting with disseminated infections with atypical mycobacteria and salmonella must be evaluated for MSMD. Disseminated salmonellosis is a peculiar manifestation in IL12Rß1 deficiency. A detailed review of literature on IL12RB1 deficiency was performed. Index case has been discussed in light of the previously published literature.
Radioguided Surgery for Gastroenteropancreatic Neuroendocrine Tumours; a Systematic Literature Review
Authors: Cockburn Katrina Clair , Toumi Zaher , Mackie Alison , Julyan Peter
Published: September 2021

Background:Radioguided surgery (RGS) for gastroenteropancreatic neuroendocrine tumours (GEP-NETs) has been suggested as a way to improve intraoperative lesion detection. This systematic literature review of reports of the use of RGS for GEP-NETs was performed to determine if there is a benefit.Methods: A literature search was conducted using Google Scholar and PubMed, and snowballing from any relevant literature. Full-text studies were included if they were published in the English Language and reported outcomes of RGS on human subjects with GEP-NETs. Qualitative data synthesis was performed. Results: 26 papers including a total of 209 patients were included. The tracers used were predominantly indium-111 pentetreotide, gallium-68 DOTA-Peptides, and technetium-99m EDDA/HYNIC-Peptides. Heterogeneous protocols make comparisons difficult, but most papers reported a benefit from the use of RGS in tumours in the gastrointestinal tract; utility in localisation of pancreatic tumours was less clear. Time between tracer administration and operation varied; from 16 hours to 8 days with indium-111, 0-24 hours with technetium-99m and 19-193 minutes with gallium-68. Eight teams reported the thresholding technique used for discrimination – four used a ratio, four statistical methods, and one looked at the sensitivity and specificity of different cut-offs. Six teams performed follow-up of 24 patients (three pancreas, eight gastrinoma, 13 gastrointestinal tract) for between 3 months and 3 years. Two patients relapsed (one pancreas, one gastrinoma) between six and 12 months post-surgery. Conclusions:RGS appears to aid in localisation of gastrointestinal NETs, but the benefit is more equivocal in pancreatic NETs. Further work into outcomes is warranted.
Learning Interpretable Pathology Features by Multi-task and Adversarial Training Improves CNN Generalization
Authors: Graziani Mara , Otalora Sebastian , Marchand-Maillet Stéphane , Müller Henning , Andrearczyk Vincent
Published: September 2021

Adopting Convolutional Neural Networks (CNNs) in daily routine of primary diagnosis requires not only near-perfect precision, but also a sufficient degree of transparency and explainability of the decision making. With physicians being accountable for the diagnosis, it is fundamental that CNNs provide a clear interpretation of their learning paradigm, ensuring that relevant pathology features are being considered. Building on top of successfully existing techniques such as multi-task learning, domain adversarial training and concept-based interpretability, this paper addresses the challenge of introducing diagnostic factors in the training objectives. Here we show that our architecture, by learning end-to-end an uncertainty-based weighting combination of multi-task and adversarial losses, is encouraged to focus on pathology features such as density and pleomorphism of nuclei, e.g. variations in size and appearance, while discarding misleading features such as staining differences. Our results on the classification of tumor in breast lymph node tissue scans show significantly improved generalization, with best average AUC 0.89 (0.01) against the baseline AUC 0.86 (0.005). This result is a starting point towards building interpretable multi-task architectures that are robust to data heterogeneity. Our code is available at https://bit.ly/356yQ2u.
Berberine Combined with Formononetin Induces Autophagy Through Downregulation of the MAPK/ERK Signaling Pathway and Inhibits the Proliferation of Nasopharyngeal Carcinoma Cells
Authors: Rui Su , Jie Liu , Jingying Fan , Ting Lin , Fangliang Zhou , faqing Tang , xianwen Wang , Daofa Tian , He Yingchun
Published: September 2021

To investigate whether the combination of berberine and formononetin can inhibit the proliferation of nasopharyngeal carcinoma cells by regulating the MAPK/ERK signaling pathway and affecting cell autophagy. Methods: RTCA and CytationTM 5 cell imaging systems were used to detect cell proliferation. MDC staining and transmission electron microscopy were used to detect cell autophagy. Western blot was used to detect the expression levels of autophagy and proliferation-related proteins and the expression levels of key proteins in the MAPK/ERK signaling pathway. Results: The combination of berberine and formononetin can inhibit the proliferation of nasopharyngeal carcinoma cells (P < 0.05) and induce autophagy (P < 0.05) and. After berberine combined with formononetin for 24 h, the expression of LC3 II/I and Beclin1 increased, whereas the expression of P62 and PCNA decreased. The expression of key proteins p-c-Raf, p-MEK, and p-ERK1/2 in the MAPK/ERK signaling pathway was downregulated (P < 0.05). Inhibiting autophagy or activating the MAPK/ERK signaling pathway significantly reduced the effect of berberine combined with formononetin on upregulating the expression of LC3 II/I and Beclin1 and downregulating the expression of P62 and PCNA. At the same time, it significantly reduced the effects of berberine combined with formononetin in inducing autophagy and inhibiting cell proliferation (P < 0.05). Conclusion: Berberine combined with formononetin inhibits the proliferation of nasopharyngeal carcinoma cells by downregulating the activity of the MAPK/ERK signaling pathway and then upregulating LC3 II/I and Beclin1, and downregulating the expression of P62 and PCNA.
Intimate Partner Violence Disclosure and Associated Factors Among Pregnant Women Attending a City Hospital in South-Western Uganda: A Cross-sectional Study
Authors: Katushabe Eve , Asiimwe John Baptist , Batwala Vincent
Published: September 2021

Background: Pregnancy-associated Intimate Partner violence (IPV) is a significant public health problem in Uganda impacting on maternal and newborn health outcomes adversely. However, IPV disclosure and related factors among gravid women have remained poorly documented in southwestern Uganda. Methods: In a cross-sectional design, 283 women attending Mbarara City Hospital Antenatal Clinic (ANC) were recruited into the study. The current analysis included 199 women reporting emotional, physical and sexual violence experiences through the present pregnancy. Results: Of the 199 (70.3%) women who experienced IPV, 99(49.7%) disclosed it to someone. Majority (66.7%) disclosed IPV to their family of birth, 55.5% to friends, 35.3% to husband’s family member, 12.1% to neighbors, 9.1% to the healthcare providers, 8.1% to religious leaders, and 3.1% to police. Gravidity, OR= 1.9[95%CI: 1.07-3.31, p=0.027], parity OR=1.9[95%CI: 1.08-3.34, p=0.026] and witnessed IPV OR: 5.4[95%CI: 1.93-14.96; p=0.001] were significantly associated with IPV disclosure.Conclusion: Half the participants disclosed their IPV experience. Majority of the women disclosed to their female family of birth and very few to healthcare workers. These findings point to the need for healthcare providers to routinely screen for IPV during antenatal care if a high IPV disclosure rate is to be achieved.
Identification of hub genes and their clinical value for predicting the development of prostate cancer from benign prostate hyperplasia by bioinformatic analysis
Authors: Chen Xi , Ma Junjie , Xu Chengdang , Wang Licheng , Yao Yicong , Wang Xinan , Zi Tong , Bian Cuidong , Wu Denglong , Wu Gang
Published: September 2021

BackgroundProstate cancer (PCa) and benign prostate hyperplasia (BPH) are commonly encountered diseases in elderly males. The two diseases have some commonalities: both are growth depend on hormone and respond to antiandrogen therapy. Some studies have shown that genetic factors are responsible for the occurrences of both diseases. There may be a correlation between BPH and PCa. MethodsThe GEO database can help determine the differentially expressed genes (DEGs) between BPH and PCa. Gene Ontology (GO) term enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis were utilized to find pathways in which the DEGs were enriched. The STRING database can provide a protein–protein interaction (PPI) network, and Cytoscape software can find hub genes in PPI network. GEPIA can be used to analyze expression and survival data for hub genes. R software was used to progress regression analysis, decision curve analysis and built nomograph. UALCAN and The Human Protein Atlas was utilized to test the results. Finally, we made clinical and cell experiments to verify the results.ResultsSixty DEGs, consisting of 15 up-regulated and 45 down-regulated genes, were found based on the GEO database. Using Cytoscape, we found 7 hub gene in the PPI network. The hub gene expression was tested on TCGA database. Except CXCR4, all hub genes expressed differently between tumor and normal samples. Meanwhile, all hub genes exclude CXCR4 has diagnostic value in predicting PCa and their mutations are risk factors leading to PCa. The expression of CSRP1, MYL9 and SNAI2 changed in different tumor stage. CSRP1 and MYH11 could affect the disease-free survival (DFS). The same results reflected in different database. In addition, we also chose three hub gene, MYC, MYL9, and SNAI2, to validate their functions in clinical specimens and cells.ConclusionThese identified hub genes can help us to understand the process and mechanism by which BPH develops into PCa and provide achievable targets for predicting which BPH patients may later develop PCa.
BiomeSeq: A Tool for the Characterization of Animal Microbiomes from Metagenomic Data
Authors: Mulholland Kelly A. , Keeler Calvin L.
Published: September 2021

BackgroundThe complete characterization of a microbiome is critical in elucidating the complex ecology of the microbial composition within healthy and diseased animals. Many microbiome studies characterize only the bacterial component, for which there are several well-developed sequencing methods, bioinformatics tools and databases available. The lack of comprehensive bioinformatics workflows and databases have limited efforts to characterize the other components existing in a microbiome. BiomeSeq is a tool for the analysis of the complete animal microbiome using metagenomic sequencing data. With its comprehensive workflow and customizable parameters and microbial databases, BiomeSeq can rapidly quantify the viral, fungal, bacteriophage and bacterial components of a sample and produce informative tables for analysis. ResultsSimulated datasets were constructed, which contained known abundances of microbial sequences, and several performance metrics were analyzed, including correlation of predicted abundance with known abundance, root mean square error and rate of speed. BiomeSeq demonstrated high precision (average of 99.52%) and sensitivity (average of 93.01%). BiomeSeq was employed in detecting and quantifying the respiratory microbiome of a commercial poultry broiler flock throughout its grow-out cycle from hatching to processing and successfully processed 780 million reads. For each microbial species detected, BiomeSeq calculated the normalized abundance, percent relative abundance, and coverage as well as the diversity for each sample. Rate of speed for each step in the pipeline, precision and accuracy were calculated to examine BiomeSeq’s performance using in silico sequencing datasets. When compared to bacterial results generated by the commonly used 16S rRNA sequencing method, BiomeSeq detected the same most abundant bacteria, including Gallibacterium, Corynebacterium and Staphylococcus, as well as several additional species. ConclusionsBiomeSeq provides for the detection and quantification of the microbiome from next-generation metagenomic sequencing data. This tool is implemented into a user-friendly container that requires one command and generates a table containing taxonomical information for each microbe detected. It also determines normalized abundance, percent relative abundance, genome coverage and sample diversity calculations for each sample.
How Does China Promote Integrated Care Development? A Policy Content Analysis
Authors: Yue Xin , Liu Lihang , Song Zhiqiang
Published: September 2021

Background: Multiple countries' experiences have illustrated that integrated care is an ideal choice regarding improving the quality of health care. In China, the central government has enacted a large number of policies to promote the development of integrated care in recent years. Yet, no existing research has examined how these policies to support the development of integrated care. In this paper we seek to address that gap. Methods: Document content analysis method was used in this paper. Data were collected by carrying out a review of integrated care policies (N=21) published from January 2015 to December 2020. The policy documents of integrated care issued by central governments are retrieved through the Internet. IHSDNSs (Integrated Health Service Delivery Networks)’s essential attributes framework was used to guide data analysis. Results: The most commonly referenced principal domains of integrated care in China were model of care, there were 45 references to the organization and management, financial allocation and incentives was the least often referenced source of information. The main purpose of reference to information was to support the reform of integrated care decision-making. Conclusions: A whole range of policies on integrated care were issued in a relatively short time. These policies propose a macro conceptual and operational framework for the development of integrated care. The development of integrated care has been mainly driven by the policy stimulus in China. However, the concrete measures still need clear negotiation and management by the local municipalities. Future policy should improve complementary policies such as financial allocation and financial incentive policy.