bluuebunny/crossref_metadata_2025 huggingface dataset:
QRS Differentiation to Improve ECG Biometrics under Different Physical Scenarios Using Multilayer Perceptron
Authors: Tirado-Martin Paloma , Liu-Jimenez Judith , Sanchez-Casanova Jorge , Sanchez-Reillo Raul
Published: October 2020

Currently, machine learning techniques are successfully applied in biometrics and Electrocardiogram (ECG) biometrics specifically. However, not many works deal with different physiological states in the user, which can provide significant heart rate variations, being these a key matter when working with ECG biometrics. Techniques in machine learning simplify the feature extraction process, where sometimes it can be reduced to a fixed segmentation. The applied database includes visits taken in two different days and three different conditions (sitting down, standing up after exercise), which is not common in current public databases. These characteristics allow studying differences among users under different scenarios, which may affect the pattern in the acquired data. Multilayer Perceptron (MLP) is used as a classifier to form a baseline, as it has a simple structure that has provided good results in the state-of-the-art. This work studies its behavior in ECG verification by using QRS complexes, finding its best hyperparameter configuration through tuning. The final performance is calculated considering different visits for enrolling and verification. Differentiation in the QRS complexes is also tested, as it is already required for detection, proving that applying a simple first differentiation gives a good result in comparison to state-of-the-art similar works. Moreover, it also improves the computational cost by avoiding complex transformations and using only one type of signal. When applying different numbers of complexes, the best results are obtained when 100 and 187 complexes in enrolment, obtaining Equal Error Rates (EER) that range between 2.79–4.95% and 2.69–4.71%, respectively.
Utilization of CD and DVD Pick-Up Heads for Scratch Inspection of Magnetic Disk in Dynamic State Using Microcontroller
Authors: Polsawat Achinee , Tipcharoen Warunee , Siritaratiwat Apirat
Published: October 2020

A non-destructive technique to inspect a scratch on all magnetic disks in the beginning process of hard disk drive (HDD) manufacturing by using CD and DVD pick-up heads as the detector is proposed. It requires a 100% disk inspection of micrometer-sized scratches in a quick measurement with low cost inventing. Most of the previous studies were in static state but this is the first time to be done in dynamic study using the microcontroller in order to promptly serve for industrial utilization. The size, position, and shape characteristic of scratches are examined using light reflection technique. The results show that, when the laser beam is targeted on a magnetic disk in a position, either scratch or non-scratch, the reflected light intensity differs. The DVD pick-up head can detect the width and the surface characteristic of the scratches, which is similar to the results from scanning electron microscope (SEM) for all scratches sizes less than 100 µm. It is also found that using a DVD pick-up head provides a better resolution of shape characteristic and roughness of scratches surface than a CD pick-up head. Hence, the scratch size of 10s µm scale on the magnetic disk can be accurately characterized by this proposed technique, which can be further utilized for magnetic disk inspection in the hard disk drive manufacturing process.
Cold Atmospheric Pressure Plasma in Wound Healing and Cancer Treatment
Authors: Boeckmann Lars , Schäfer Mirijam , Bernhardt Thoralf , Semmler Marie Luise , Jung Ole , Ojak Gregor , Fischer Tobias , Peters Kirsten , Nebe Barbara , Müller-Hilke Brigitte , Seebauer Christian , Bekeschus Sander , Emmert Steffen
Published: October 2020

Plasma medicine is gaining increasing attention and is moving from basic research into clinical practice. While areas of application are diverse, much research has been conducted assessing the use of cold atmospheric pressure plasma (CAP) in wound healing and cancer treatment—two applications with entirely different goals. In wound healing, a tissue-stimulating effect is intended, whereas cancer therapy aims at killing malignant cells. In this review, we provide an overview of the latest clinical and some preclinical research on the efficacy of CAP in wound healing and cancer therapy. Furthermore, we discuss the current understanding of molecular signaling mechanisms triggered by CAP that grant CAP its antiseptic and tissue regenerating or anti-proliferative and cell death-inducing properties. For the efficacy of CAP in wound healing, already substantial evidence from clinical studies is available, while evidence for therapeutic effects of CAP in oncology is mainly from in vitro and in vivo animal studies. Efforts to elucidate the mode of action of CAP suggest that different components, such as ultraviolet (UV) radiation, electromagnetic fields, and reactive species, may act synergistically, with reactive species being regarded as the major effector by modulating complex and concentration-dependent redox signaling pathways.
Sourcing and Propagation of Pontechium maculatum for Horticulture and Species Restoration
Authors: Nowak Barbara , Sitek Ewa , Augustynowicz Joanna
Published: October 2020

Pontechium maculatum, a species of ornamental, apicultural, health and medicinal value, is threatened in some Central European countries including Poland. Its propagation using seeds or in vitro techniques is needed for multiple applications including conservation. Generative propagation efficacy of P. maculatum plants representing different genetic resources (received from botanical gardens in Germany and in Poland) propagated from seeds or in tissue culture was assessed. Moreover, an efficient technique of propagation of P. maculatum using in vitro shoot culture from seedlings was elaborated for the first time. The highest propagation efficacy was noted for German plants of seed origin. The ability of seeds to germinate was similar for all plants; however, seeds were in a state of dormancy, which was broken by GA3. After two years of storage, the seeds still retained the ability to germinate though seeds from propagated in vitro plants germinated more poorly than those from seed-originated plants. The ploidy assessment showed that some in vitro-origin plants had altered DNA content. The results indicate that efficacy of generative propagation of P. maculatum is resource dependent. Furthermore, results suggest that cultivation in vitro influenced some generative features of examined species, which makes this way of P. maculatum propagation a valuable source of genetic variation and a potential breeding tool.
Larvicidal Action of Cannabidiol Oil and Neem Oil against Three Stored Product Insect Pests: Effect on Survival Time and in Progeny
Authors: Mantzoukas Spiridon , Ntoukas Aristeidis , Lagogiannis Ioannis , Kalyvas Nikolaos , Eliopoulos Panagiotis , Poulas Konstantinos
Published: October 2020

Stored product pests can be detrimental to agricultural produce. As much as chemical pesticides are effective control agents, they involve several environmental and health risks. Within the framework of studies on alternative pest management methods, interest has focused on a plethora of plants whose extracts have demonstrated promising action as insecticides. Azadirachta indica and the derived neem oil have been extensively tested against many harmful insect species. In contrast, Cannabis sativa L. and its main compound, CBD, a highly concentrated cannabinoid, have not been investigated much. The present study examined the potential insecticidal activity of CBD and neem oils against 4th instar larvae of Tribolium confusum, Oryzaephilus surinamensis and Plodia interpunctella on wheat, rice and corn seeds. Treatment efficacy was expressed in terms of larval mortality. Mortality was observed in relation to dosage, time exposure intervals and product types. The results showed clear pesticidal activity for both oils, which at high doses induced significant mortality. The treatments produced significantly fewer offspring in the insect species tested than the control. The efficacy of treatment in progeny suppression was, as expected, dose dependent.
The Role of Autophagy in Osteoclast Differentiation and Bone Resorption Function
Authors: Montaseri Azadeh , Giampietri Claudia , Rossi Michela , Riccioli Anna , Del Fattore Andrea , Filippini Antonio
Published: October 2020

Autophagy is an evolutionary conserved and highly regulated recycling process of cellular wastes. Having a housekeeping role, autophagy through the digestion of domestic cytosolic organelles, proteins, macromolecules, and pathogens, eliminates unnecessary materials and provides nutrients and energy for cell survival and maintenance. The critical role of autophagy and autophagy-related proteins in osteoclast differentiation, bone resorption, and maintenance of bone homeostasis has previously been reported. Increasing evidence reveals that autophagy dysregulation leads to alteration of osteoclast function and enhanced bone loss, which is associated with the onset and progression of osteoporosis. In this review, we briefly consolidate the current state-of-the-art technology regarding the role of autophagy in osteoclast function in both physiologic and pathologic conditions to have a more general view on this issue.
Dissecting the Interaction of FGF8 with Receptor FGFRL1
Authors: Zhuang Lei , Vogel Monique , Villiger Peter M. , Trueb Beat
Published: October 2020

In mammals, the novel protein fibroblast growth factor receptor-like 1 (FGFRL1) is involved in the development of metanephric kidneys. It appears that this receptor controls a crucial transition of the induced metanephric mesenchyme to epithelial renal vesicles, which further develop into functional nephrons. FGFRL1 knockout mice lack metanephric kidneys and do not express any fibroblast growth factor (FGF) 8 in the metanephric mesenchyme, suggesting that FGFRL1 and FGF8 play a decisive role during kidney formation. FGFRL1 consists of three extracellular immunoglobulin (Ig) domains (Ig1-Ig2-Ig3), a transmembrane domain and a short intracellular domain. We have prepared the extracellular domain (Ig123), the three individual Ig domains (Ig1, Ig2, Ig3) as well as all combinations containing two Ig domains (Ig12, Ig23, Ig13) in recombinant form in human cells. All polypeptides that contain the Ig2 domain (Ig123, Ig12, Ig23, Ig2) were found to interact with FGF8 with very high affinity, whereas all constructs that lack the Ig2 domain (Ig1, Ig3, Ig13) poorly interacted with FGF8 as shown by ELISA and surface plasmon resonance. It is therefore likely that FGFRL1 represents a physiological receptor for FGF8 in the kidney and that the ligand primarily binds to the Ig2 domain of the receptor. With Biacore experiments, we also measured the affinity of FGF8 for the different constructs. All constructs containing the Ig2 domain showed a rapid association and a slow dissociation phase, from which a KD of 2–3 × 10−9 M was calculated. Our data support the hypothesis that binding of FGF8 to FGFRL1 could play an important role in driving the formation of nephrons in the developing kidney.
Comparison of Effects of Metformin, Phenformin, and Inhibitors of Mitochondrial Complex I on Mitochondrial Permeability Transition and Ischemic Brain Injury
Authors: Skemiene Kristina , Rekuviene Evelina , Jekabsone Aiste , Cizas Paulius , Morkuniene Ramune , Borutaite Vilmante
Published: October 2020

Damage to cerebral mitochondria, particularly opening of mitochondrial permeability transition pore (MPTP), is a key mechanism of ischemic brain injury, therefore, modulation of MPTP may be a potential target for a neuroprotective strategy in ischemic brain pathologies. The aim of this study was to investigate whether biguanides—metformin and phenformin as well as other inhibitors of Complex I of the mitochondrial electron transfer system may protect against ischemia-induced cell death in brain slice cultures by suppressing MPTP, and whether the effects of these inhibitors depend on the age of animals. Experiments were performed on brain slice cultures prepared from 5–7-day (premature) and 2–3-month old (adult) rat brains. In premature brain slice cultures, simulated ischemia (hypoxia plus deoxyglucose) induced necrosis whereas in adult rat brain slice cultures necrosis was induced by hypoxia alone and was suppressed by deoxyglucose. Phenformin prevented necrosis induced by simulated ischemia in premature and hypoxia-induced—in adult brain slices, whereas metformin was protective in adult brain slices cultures. In premature brain slices, necrosis was also prevented by Complex I inhibitors rotenone and amobarbital and by MPTP inhibitor cyclosporine A. The latter two inhibitors were protective in adult brain slices as well. Short-term exposure of cultured neurons to phenformin, metformin and rotenone prevented ionomycin-induced MPTP opening in intact cells. The data suggest that, depending on the age, phenformin and metformin may protect the brain against ischemic damage possibly by suppressing MPTP via inhibition of mitochondrial Complex I.
The Role of Natural Compounds and their Nanocarriers in the Treatment of CNS Inflammation
Authors: Khadka Bikram , Lee Jae-Young , Park Dong Ho , Kim Ki-Taek , Bae Jong-Sup
Published: October 2020

Neuroinflammation, which is involved in various inflammatory cascades in nervous tissues, can result in persistent and chronic apoptotic neuronal cell death and programmed cell death, triggering various degenerative disorders of the central nervous system (CNS). The neuroprotective effects of natural compounds against neuroinflammation are mainly mediated by their antioxidant, anti-inflammatory, and antiapoptotic properties that specifically promote or inhibit various molecular signal transduction pathways. However, natural compounds have several limitations, such as their pharmacokinetic properties and stability, which hinder their clinical development and use as medicines. This review discusses the molecular mechanisms of neuroinflammation and degenerative diseases of CNS. In addition, it emphasizes potential natural compounds and their promising nanocarriers for overcoming their limitations in the treatment of neuroinflammation. Moreover, recent promising CNS inflammation-targeted nanocarrier systems implementing lesion site-specific active targeting strategies for CNS inflammation are also discussed.
Impact of H2O2 on the Lactic and Formic Acid Degradation in Presence of TiO2 Rutile and Anatase Phases under UV and Visible Light
Authors: Holm Annika , Hamandi Marwa , Sahel Karima , Dappozze Frederic , Guillard Chantal
Published: October 2020

The degradation rates of formic acid and lactic acid in the presence and absence of H2O2 were studied, utilizing several TiO2 catalysts: PC105 (100% anatase), MPT 625 (100% rutile), and P25 (80% anatase/20% rutile), and the results were discussed with regards to the current literature. The impact of hydrogen peroxide on the photocatalytic efficiency of eleven TiO2 samples was then determined, using commercial anatase structures (PC105, PC500, UV100), commercial mixed anatase/rutile (P25 and P90), and six rutile (two commercial samples: MPT 625 and C-R160, and four home-made rutile samples were synthesized by TiCl4 hydrolysis). The effect of catalyst surface area and TiO2 phase on the degradation rate of lactic acid (LA) and the decomposition of H2O2 was studied and discussed in regard to the active species generated. The intermediate products formed in the absence and presence of H2O2 were also an important factor in the comparison. Finally, the efficiency of the degradation of LA and formic acid (FA) in the presence of rutile and H2O2 was determined under visible light, and their reactivity was compared. The intermediate products formed in the degradation of LA were identified and quantified and compared to those obtained under UV (Ultra-Violet).
Controlling the Degree of Coverage of the Pt Shell in Pd@Pt Core–Shell Nanocubes for Methanol Oxidation Reaction
Authors: Xiao Xiangyun , Jung Euiyoung , Yoo Sehyun , Lim Taeho , Kim Jinheung , Yu Taekyung
Published: October 2020

The synthesis of Pd@Pt core–shell nanocubes was achieved through a direct seed-mediated growth method. This process represents a simple and cost-effective way to produce core–shell nanocubes. The morphology of the Pd@Pt core–shell nanocubes varied from simple cubic to concave cubic, depending on the reducing agent and the Pt content. The selection of the reducing agent is important because the reduction rate is directly related to the shell growth. The catalytic activity and stability of the Pd@Pt core–shell nanocubes in the methanol oxidation reaction were different for the nanocubes with partial and full Pt shells.
Highly Effective, Regiospecific Hydrogenation of Methoxychalcone by Yarrowia lipolytica Enables Production of Food Sweeteners
Authors: Łużny Mateusz , Kozłowska Ewa , Kostrzewa-Susłow Edyta , Janeczko Tomasz
Published: October 2020

We describe the impact of the number and location of methoxy groups in the structure of chalcones on the speed and efficiency of their transformation by unconventional yeast strains. The effect of substrate concentration on the conversion efficiency in the culture of the Yarrowia lipolytica KCh 71 strain was tested. In the culture of this strain, monomethoxychalcones (2′-hydroxy-2″-, 3″- and 4″-methoxychalcone) were effectively hydrogenated at over 40% to the specific dihydrochalcones at a concentration of 0.5 g/L of medium after just 1 h of incubation. A conversion rate of over 40% was also observed for concentrations of these compounds of 1 g/L of medium after three hours of transformation. As the number of methoxy substituents increases in the chalcone substrate, the rate and efficiency of transformation to dihydrochalcones decreased. The only exception was 2′-hydroxy-2″,5″-dimethoxychalcone, which was transformed into dihydrochalcone by strain KCh71 with a yield comparable to that of chalcone containing a single methoxy group.
Structure, Oxidation Resistance, Mechanical, and Tribological Properties of N- and C-Doped Ta-Zr-Si-B Hard Protective Coatings Obtained by Reactive D.C. Magnetron Sputtering of TaZrSiB Ceramic Cathode
Authors: Kiryukhantsev-Korneev Ph. V. , Sytchenko A. D. , Vorotilo S. A. , Klechkovskaya V. V. , Lopatin V. Yu. , Levashov E. A.
Published: October 2020

Coatings in the Ta-Zr-Si-B-C-N system were produced by magnetron sputtering of a TaSi2-Ta3B4-(Ta,Zr)B2 ceramic target in the Ar medium and Ar-N2 and Ar-C2H4 gas mixtures. The structure and composition of coatings were studied using scanning electron microscopy, glow discharge optical emission spectroscopy, energy-dispersion spectroscopy, and X-ray diffraction. Mechanical and tribological properties of coatings were determined using nanoindentation and pin-on-disk tests using 100Cr6 and Al2O3 balls. The oxidation resistance of coatings was evaluated by microscopy and X-ray diffraction after annealing in air at temperatures up to 1200 °C. The reactively-deposited coatings containing from 30% to 40% nitrogen or carbon have the highest hardness up to 29 GPa and elastic recovery up to 78%. Additionally, coatings with a high carbon content demonstrated a low coefficient of friction of 0.2 and no visible signs of wear when tested against 100Cr6 ball. All coatings except for the non-reactive ones can resist oxidation up to a temperature of 1200 °C thanks to the formation of a protective film based on Ta2O5 and SiO2 on their surface. Coatings deposited in Ar-N2 and Ar-C2H4 demonstrated superior resistance to thermal cycling in conditions 20-T−20 °C (where T = 200–1000 °C). The present article compares the structure and properties of reactive and “standard-inert atmosphere” deposited coatings to develop recommendations for optimizing the composition.
Synthesis and Antibacterial Aspects of Graphitic C3N4@Polyaniline Composites
Authors: Oves Mohammad , Ansari Mohammad Omaish , Darwesh Reem , Hussian Afzal , Alajmi Mohamed F. , Qari Huda A.
Published: October 2020

In this work, Pani and Pani@g-C3N4 was synthesized by in situ oxidative polymerization methodology of aniline, in the presence of g-C3N4. The as prepared Pani@g-C3N4 was characterized by scanning electron microscopy, transmission electron microscopy and X-ray diffraction (XRD). The morphological analysis showed well dispersed Pani in g-C3N4, as well as the coating of Pani on g-C3N4. The XRD further revealed this, and peaks of Pani as well as g-C3N4 was observed, thereby suggesting successful synthesis of the composite. The DC electrical conductivity studies under isothermal and cyclic aging conditions showed high stability of composites over 100 °C. Further, the synthesized composite material proved to be an excellent antimicrobial agent against both type i.e., gram positive Streptococcus pneumoniae and negative bacteria Escherichia coli. In the zone inhibition assay 18 ± 0.5, 16 ± 0.75 and 20 ± 0.5, 22 ± 0.5 mm zone diameter were found against E. coli and S. pneumoniae in presence of pure g-C3N4 and Pani@g-C3N4 at 50 µg concentrations, respectively. Further antimicrobial activity in the presence of sunlight in aqueous medium showed that Pani@g-C3N4 is more potent than pure g-C3N4.
Novel Tunable Green-Red Luminescence in Mn2+ Doped Ca9Tb(PO4)7 Phosphors Based on the Mn2+ Regulation and Energy Transfer
Authors: Yang Bingwen , Feng Yefeng , Zhao Qinghu , He Miao , Lv Yang
Published: October 2020

β-Ca3(PO4)2 type phosphors Ca9Tb(PO4)7:Mn2+ were fabricated by high temperature solid state reaction. Under 377 nm light excitation, the Ca9Tb(PO4)7 host displays the green emission attributable to the characteristic emission of Tb3+ ions peaking at 488, 542, 586, and 620 nm, respectively. The red broadband emission is observed when Ca9Tb(PO4)7 is doped with Mn2+ ions. The emission is attributed to the energy transfer from Tb3+ to Mn2+ ions; this facilitates the realization of the tunable green–red emission. The energy transfer mechanism from Tb3+ to Mn2+ is defined as quadrupole–quadrupole interaction. Furthermore, the thermal stability of Ca9Tb(PO4)7:Mn2+ samples has been studied, and it can maintain half the emission intensity exceeding 424 K. This demonstrates their potential applications in white light LEDs (w-LEDs).
Constitutive Modeling of New Synthetic Hybrid Fibers Reinforced Concrete from Experimental Testing in Uniaxial Compression and Tension
Authors: Zainal S. M. Iqbal S. , Hejazi Farzad , Aziz Farah N. A. Abd. , Jaafar Mohd Saleh
Published: October 2020

Hybridization of fibers in concrete yields a variety of applications due to its benefits compared to conventional concrete or concrete with single type-fiber. However, the Finite Element (FE) modeling of these new materials for numerical analyses are very challenging due to the lack of analytical data for these specific materials. Therefore, an attempt has been made to develop Hybrid Fiber Reinforced Concrete (HyFRC) materials with High Range Water-Reducing Admixture (HRWRA) during the concrete mixing process and conduct experimental study to evaluate the behavior of the proposed materials. Constitutive models for each of the materials are formulated to be used as analytical models in numerical analyses. The acquired data are then used to formulate mathematical equations, governing the stress–strain behavior of the proposed HyFRC materials to measure the accuracy of the proposed models. The experimental testing indicated that the Ferro with Ferro mix-combination improved the performance of concrete in the elastic stage while the Ferro with Ultra-Net combination has the highest compressive strain surplus in the plastic stage. In tension, the Ferro with Ferro mix displayed the highest elastic behavior improvement while the Ferro with Ultra-Net designs proved superior in the plastic range, providing additional toughness to conventional concrete.
Altered Regional Cerebral Blood Perfusion in Mild Cognitive Impairment Patients with Dizziness
Authors: Na Seunghee , Im Jooyeon Jamie , Jeong Hyeonseok , Lee Eek-Sung , Lee Tae-Kyeong , Chung Yong-An , Song In-Uk
Published: October 2020

Dizziness is a common symptom among the general population, especially in the elderly. Previous studies have reported that dizziness may be associated with various cognitive functions including memory impairment. However, few studies have investigated the neural correlates of dizziness in patients with cognitive impairment. The aim of this study was to examine regional cerebral blood flow (rCBF) in mild cognitive impairment (MCI) patients with or without dizziness using single photon emission computed tomography (SPECT). A total of 50 patients with MCI were recruited. All participants underwent technetium-99m ethyl cysteinate dimer brain SPECT and a neuropsychological battery and completed the Dizziness Handicap Inventory (DHI). Participants were divided into a dizziness group (DHI ≥ 1, n = 18) and a non-dizziness group (DHI = 0, n = 32). Voxel wise differences in rCBF between the groups were estimated. SPECT analysis revealed decreased rCBF in the left superior temporal gyrus, left lateral orbital gyrus, and right middle frontal gyrus in the dizziness group compared with the non-dizziness group (p < 0.005). No significant clusters of increased rCBF were observed in the dizziness group compared with the non-dizziness group. Results of the neuropsychological tests showed a significant difference in Controlled Oral Word Association Test performance between MCI patients with and without dizziness. In conclusion, MCI patients with dizziness showed multifocal frontal and left temporal hypoperfusion compared with patients without dizziness. Our results suggest that hypoperfusion in the frontal and temporal cortices might be reflecting the negative impact of dizziness in MCI patients.
The Effect of High-Frequency Vibration on Tooth Movement and Alveolar Bone in Non-Growing Skeletal Class II High Angle Orthodontic Patients: Case Series
Authors: El-Bialy Tarek
Published: October 2020

This study presents a novel technique utilizing high-frequency vibration to shorten treatment time and preserve alveolar bone in challenging orthodontic cases that have been treated with Invisalign® clear aligners. Four non-growing orthodontic patients (age range 14–47 years old) with Class II skeletal patterns (convex profiles with retrognathic mandibles) who sought correction of their crowded teeth and non-surgical correction of their convex profiles were included in this study. These patients were treated using Invisalign clear aligners together with high-frequency vibration (HFV) devices (120 Hz) (VPro5™) that were used by all patients for five minutes per day during active orthodontic treatment. Vertical control and forward rotation of the mandible for each patient was achieved through pre-programming the Invisalign to produce posterior teeth intrusion. Successful forward rotation of the mandibles achieved in all patients led to improvement of their facial convex profiles (apical base relationship (ANB) improved 2.1 ± 0.5 degrees; FMA (Frankfurt mandibular plane angle) improved 1.2 + 1.1 degrees). Dental decompensation was achieved by lingual tipping of the lower incisors and palatal root torque of upper incisors. The use of HFV together with Invisalign facilitated achieving these results within a 12 ± 6 months period. In addition, more bone labial to the lower incisors after their lingual movement was noted. In conclusion, the use of HFV concurrent with SmartTrack Invisalign aligners allowed complex tooth movement and forward mandibular projection without surgery in non-growing patients with skeletal Class II relationships. The clinical impact and implications of this case series are: (1) the use of HFV facilitates complex orthodontic tooth movement including posterior teeth intrusion and incisor decompensation; (2) forward mandibular projection of the mandible and increased bone formation labial to lower incisors can be achieved in non-growing patients that may minimize the need for surgical intervention in similar cases or gum recession due to lower incisors labial inclination.
CED-Net: Crops and Weeds Segmentation for Smart Farming Using a Small Cascaded Encoder-Decoder Architecture
Authors: Khan Abbas , Ilyas Talha , Umraiz Muhammad , Mannan Zubaer Ibna , Kim Hyongsuk
Published: October 2020

Convolutional neural networks (CNNs) have achieved state-of-the-art performance in numerous aspects of human life and the agricultural sector is no exception. One of the main objectives of deep learning for smart farming is to identify the precise location of weeds and crops on farmland. In this paper, we propose a semantic segmentation method based on a cascaded encoder-decoder network, namely CED-Net, to differentiate weeds from crops. The existing architectures for weeds and crops segmentation are quite deep, with millions of parameters that require longer training time. To overcome such limitations, we propose an idea of training small networks in cascade to obtain coarse-to-fine predictions, which are then combined to produce the final results. Evaluation of the proposed network and comparison with other state-of-the-art networks are conducted using four publicly available datasets: rice seeding and weed dataset, BoniRob dataset, carrot crop vs. weed dataset, and a paddy–millet dataset. The experimental results and their comparisons proclaim that the proposed network outperforms state-of-the-art architectures, such as U-Net, SegNet, FCN-8s, and DeepLabv3, over intersection over union (IoU), F1-score, sensitivity, true detection rate, and average precision comparison metrics by utilizing only (1/5.74 × U-Net), (1/5.77 × SegNet), (1/3.04 × FCN-8s), and (1/3.24 × DeepLabv3) fractions of total parameters.
Nonuniformity-Immune Read-In Integrated Circuit for Infrared Sensor Testing Systems
Authors: Cho Minji , Lee Heechul , Woo Doohyung
Published: October 2020

In this study, a novel IR projector driver that can minimize nonuniformity in electric circuits, using a dual-current-programming structure, is proposed to generate high-quality infrared (IR) scenes for accurate sensor evaluation. Unlike the conventional current-mode structure, the proposed system reduces pixel-to-pixel nonuniformity by assigning two roles (data sampling and current driving) to a single transistor. A prototype of the proposed circuit was designed and fabricated using the SK-Hynix 0.18 µm CMOS process, and its performance was analyzed using post-layout simulation data. It was verified that nonuniformity, which is defined as the standard deviation divided by the mean radiance, could be reduced from 21% to less than 0.1%.
Brain-Inspired Self-Organization with Cellular Neuromorphic Computing for Multimodal Unsupervised Learning
Authors: Khacef Lyes , Rodriguez Laurent , Miramond Benoît
Published: October 2020

Cortical plasticity is one of the main features that enable our ability to learn and adapt in our environment. Indeed, the cerebral cortex self-organizes itself through structural and synaptic plasticity mechanisms that are very likely at the basis of an extremely interesting characteristic of the human brain development: the multimodal association. In spite of the diversity of the sensory modalities, like sight, sound and touch, the brain arrives at the same concepts (convergence). Moreover, biological observations show that one modality can activate the internal representation of another modality when both are correlated (divergence). In this work, we propose the Reentrant Self-Organizing Map (ReSOM), a brain-inspired neural system based on the reentry theory using Self-Organizing Maps and Hebbian-like learning. We propose and compare different computational methods for unsupervised learning and inference, then quantify the gain of the ReSOM in a multimodal classification task. The divergence mechanism is used to label one modality based on the other, while the convergence mechanism is used to improve the overall accuracy of the system. We perform our experiments on a constructed written/spoken digits database and a Dynamic Vision Sensor (DVS)/EletroMyoGraphy (EMG) hand gestures database. The proposed model is implemented on a cellular neuromorphic architecture that enables distributed computing with local connectivity. We show the gain of the so-called hardware plasticity induced by the ReSOM, where the system’s topology is not fixed by the user but learned along the system’s experience through self-organization.
Software-in-Loop Simulation Environment for Electromagnetic Underwater Wireless Sensor Networks over STANAG 5066 Protocol
Authors: Alonso-Eugenio Victor , Guerra Victor , Zazo Santiago , Perez-Alvarez Ivan
Published: October 2020

In this work, the development of a software-in-loop platform to carry out Underwater Wireless Sensor Network (UWSN) simulations using a real-time STANAG 5066 stack is presented. The used protocol stack is part of a real-world implementation of an underwater wireless node based on ElectroMagnetic (EM) Underwater Radio Frequency Communication (EM-URFC), framed within Spanish Government’s project HERAKLES. The main objective of this work was to assess the suitability of this software-in-loop approach for carrying out realistic UWSN simulations. In addition to a detailed description of the simulation process, several simulations considering an illustrative network topology are performed, analyzing the impact of different critical parameters on the network performance. The conclusions suggest that the developed software-in-loop platform is suitable to carry out UWSN network tests using a real-world implementation of the STANAG 5066 stack. Moreover, other real-time protocol stacks may be easily adapted with minor modifications.
Origins and Consequences of Chromosomal Instability: From Cellular Adaptation to Genome Chaos-Mediated System Survival
Authors: Ye Christine J. , Sharpe Zachary , Heng Henry H.
Published: October 2020

When discussing chromosomal instability, most of the literature focuses on the characterization of individual molecular mechanisms. These studies search for genomic and environmental causes and consequences of chromosomal instability in cancer, aiming to identify key triggering factors useful to control chromosomal instability and apply this knowledge in the clinic. Since cancer is a phenomenon of new system emergence from normal tissue driven by somatic evolution, such studies should be done in the context of new genome system emergence during evolution. In this perspective, both the origin and key outcome of chromosomal instability are examined using the genome theory of cancer evolution. Specifically, chromosomal instability was linked to a spectrum of genomic and non-genomic variants, from epigenetic alterations to drastic genome chaos. These highly diverse factors were then unified by the evolutionary mechanism of cancer. Following identification of the hidden link between cellular adaptation (positive and essential) and its trade-off (unavoidable and negative) of chromosomal instability, why chromosomal instability is the main player in the macro-cellular evolution of cancer is briefly discussed. Finally, new research directions are suggested, including searching for a common mechanism of evolutionary phase transition, establishing chromosomal instability as an evolutionary biomarker, validating the new two-phase evolutionary model of cancer, and applying such a model to improve clinical outcomes and to understand the genome-defined mechanism of organismal evolution.
Predicting the Saturated Hydraulic Conductivity of Clayey Soils and Clayey or Silty Sands
Authors: Bilardi Stefania , Ielo Domenico , Moraci Nicola
Published: October 2020

Predictive models able to provide a reliable estimate of hydraulic conductivity can be useful in various geotechnical applications. Since most of the existing predictive methods for saturated hydraulic conductivity estimation are valid only for a limited range of soils or can be applied under certain restrictive conditions, a new method applicable to clayey soils and clayey or silty sands having a wide range of values of soil index properties is proposed in this study. For this purpose, 329 saturated hydraulic conductivity values, obtained by laboratory tests carried out on different soils, were collected in a database and used to develop five equations using a multiple regression approach. Each equation correlates the hydraulic conductivity with one or more geotechnical parameters. An equation was developed that predicts, within an order of magnitude, the saturated hydraulic conductivity in the range from 1.2 × 10−11 to 3.9 × 10−6 m/s, based on simple geotechnical parameters (i.e., clay content, void ratio, plastic limit, and silt content).
Sustainability and Versatility of the ABCDE Protocol for Stress Echocardiography
Authors: Picano Eugenio , Zagatina Angela , Wierzbowska-Drabik Karina , Borguezan Daros Clarissa , D’Andrea Antonello , Ciampi Quirino
Published: October 2020

For the past 40 years, the methodology for stress echocardiography (SE) has remained basically unchanged. It is based on two-dimensional, black and white imaging, and is used to detect regional wall motion abnormalities (RWMA) in patients with known or suspected coronary artery disease (CAD). In the last five years much has changed and RWMA is not enough on its own to stratify patient risk and dictate therapy. Patients arriving at SE labs often have comorbidities and are undergoing full anti-ischemic therapy. The SE positivity rate based on RWMA fell from 70% in the eighties to 10% in the last decade. The understanding of CAD pathophysiology has shifted from a regional hydraulic disease to a systemic biologic disease. The conventional view of CAD encouraged the use of coronary anatomic imaging for diagnosis and the oculo-stenotic reflex for the deployment of therapy. This has led to a clinical oversimplification that ignores the lessons of pathophysiology and epidemiology, and in fact, CAD is not synonymous with ischemic heart disease. Patients with CAD may also have other vulnerabilities such as coronary plaque (step A of ABCDE-SE), alveolar-capillary membrane and pulmonary congestion (step B), preload and contractile reserve (step C), coronary microcirculation (step D) and cardiac autonomic balance (step E). The SE methodology based on two-dimensional echocardiography is now integrated with lung ultrasound (step B for B-lines), volumetric echocardiography (step C), color- and pulsed-wave Doppler (step D) and non-imaging electrocardiogram-based heart rate assessment (step E). In addition, qualitative assessment based on the naked eye has now become more quantitative, has been improved by contrast and based on cardiac strain and artificial intelligence. ABCDE-SE is now ready for large scale multicenter testing in the SE2030 study.
Low ALT Levels Associated with Poor Outcomes in 8700 Hospitalized Heart Failure Patients
Authors: Segev Amitai , Itelman Edward , Avaky Chen , Negru Liat , Shenhav-Saltzman Gilat , Grupper Avishay , Wasserstrum Yishay , Segal Gad
Published: October 2020

Sarcopenia and frailty are causes for morbidity and mortality amongst heart failure (HF) patients. Low alanine transaminase (ALT) is a marker for these syndromes and, therefore, could serve as a biomarker for the prognostication of HF patients. We performed a retrospective analysis of all consecutive hospitalized HF patients in our institute in order to find out whether low ALT values would be a biomarker for poor outcomes. Our cohort included 11,102 patients, 35.6% categorized as heart failure with reduced ejection fraction. We excluded patients with ALT > 40 IU/L and cirrhosis. 8700 patients were followed for a median duration of 22 months and included in a univariate analysis. Patients with ALT < 10 IU/L were older (mean age 78.6 vs. 81.8, p < 0.001), had past stroke (24.6% vs. 19.6%, p < 0.001), dementia (7.7% vs. 4.6%, p < 0.001), and malignancy (13.4% vs. 10.2%, p = 0.003). Hospitalization length was longer in the low-ALT group (4 vs. 3 days, p < 0.001), and the rate of acute kidney injury during hospitalization was higher (19.1% vs. 15.6%; p = 0.006). The in-hospital mortality rate was higher in the low-ALT group (6.5% vs. 3.9%; p < 0.001). Long-term mortality was also higher (73.3% vs. 61.5%; p < 0.001). In a multivariate regression analysis, ALT < 10 IU/L had a 1.22 hazard ratio for mortality throughout the follow-up period (CI = 1.09–1.36; p < 0.001). Low ALT plasma level, a biomarker for sarcopenia and frailty, can assist clinicians in prognostic stratification of heart failure patients.
Onlay Uncemented Lateralized Reverse Shoulder Arthroplasty for Fracture Sequelae Type 1 with Valgus/Varus Malunion: Deltoid Lengthening and Outcomes
Authors: Romano Alfonso Maria , Braile Adriano , Casillo Pasquale , Nastrucci Guglielmo , Susanna Massimiliano , Di Giunta Angelo , Ascione Francesco
Published: October 2020

The successful treatment of proximal humeral fractures remains challenging for shoulder surgeons, and failure rates are high, regardless of initial treatment. This study aimed to analyze the clinical and radiographic midterm results of onlay lateralized cementless stem reverse shoulder arthroplasty (RSA) in patients with valgus/varus malunion proximal humerus fracture sequelae without metaphyseal osteotomy. We retrospectively studied 35 cases with the diagnosis of fracture sequelae of the proximal part of the humerus with valgus/varus malunion. The mean duration of follow-up was 4.6 years (range, 2 to 7 years), and the mean time between fracture and arthroplasty was 6 years (1 to 32 years). Seventeen patients (48.6%) had initially been treated nonoperatively. The Constant score (CS), active range of motion, and radiographs of the affected shoulders, as well as the acromion to greater tuberosity (AGT) distance and deltoid length (DL), were analyzed before surgery and at their latest follow-up. A total of thirty-three patients (94.3%) rated their outcome as very good or good. Mean CS, forward flexion, and external rotation improved significantly (p < 0.0001), as did internal rotation and pain (p < 0.05). AGT distance significantly increased postoperatively from 14.7 to 43.3 mm, as did DL from 143 to 170 mm (p < 0.05). There was no correlation between the outcomes and valgus/varus deformity, previous surgeries, or AGT distance/DL. A total of four complications occurred (11.4%): two dislocations were detected (5.7%) and successfully revised with a longer cemented stem. Onlay lateralized uncemented stem RSA improves clinical outcomes and decreases complications when treating valgus/varus malunion fracture sequelae, avoiding intraoperative technical challenges, such as tuberosities osteotomy conscious of bone loss and proper deltoid tensioning.
Uses of Inflammatory Markers for Differentiation of Intrahepatic Mass-Forming Cholangiocarcinoma from Liver Abscess: Case-Control Study
Authors: Lee Sun Chul , Kim Sun Ju , Yu Min Heui , Lee Kyong Joo , Cha Yong Sung
Published: October 2020

Background: Pyogenic liver abscess (LA) is difficult to distinguish from intrahepatic mass-forming cholangiocarcinoma (IMCC) in the emergency department (ED). We evaluated the predictive ability of white blood cells (WBC) and C-reactive protein (CRP) levels, neutrophil to lymphocyte ratio (NLR), platelet to lymphocyte ratio (PLR), and delta neutrophil index (DNI) in LA and IMCC in the ED. Methods: Forty patients with IMCC between January 2011 and December 2018 were included in this study. For each patient with IMCC, two control patients with LA were enrolled based on matching age and sex,—i.e., 80 patients with LA. Results: Inflammatory markers, including WBC, PLR, NLR, DNI, and CRP were significantly higher in the LA group than in the IMCC group. For both groups, the area under the curve (AUC) of the initial CRP value was significantly higher (AUC: 0.909) than that of the initial serum WBC count, PLR, and DNI levels. On multivariable logistic regression analysis with inflammatory markers, serum CRP (odds ratio, 1.290; 95% confidence interval, 1.148–1.449, p < 0.001) was the only significant predictor for differentiation between the LA and IMCC groups. Conclusion: Serum CRP may be a potential inflammatory marker to differentiate IMCC from LA in the ED.
Implementation and Advancement of a Rural Residential Concentration Strategy in the Suburbs of Shanghai
Authors: Shi Yishao , Ren Haoran , Guo Xiatong , Tao Tianhui
Published: October 2020

Rural residential concentration was one of the important tasks of the “Three Concentrations” strategy implemented in the suburbs of Shanghai in the mid-1990s. The aims of this paper are to comprehensively evaluate the process, pattern and effects of residential concentration in the suburbs of Shanghai over the past 20 years, clarify the direction and focus of development, and propose suggestions for existing deficiencies. Based on remote sensing images and statistical data, the implementation and effects of the rural residential concentration strategy from 1990 to 2015 were analysed using landscape indexes and geospatial analysis. The results are as follows: (1) according to the changes in the landscape pattern and spatial structure, the trends in population concentration in the suburbs of Shanghai are obvious. (2) Before 1995, the trend of population diffusion was conspicuous. After 1995, the period of population diffusion gradually shifted to a period of population agglomeration. The rate of population concentration increased rapidly from 2000 to 2010 and then became moderate after 2010. (3) In 1990, most of the rural residential areas were distributed within 14–52 km of the city centre, the distribution of residential area in each ring was relatively uniform, and the overall distribution was scattered and uniform. By 2015, the rural population gradually converged in the inner suburbs, and the centralized distribution gradually changed to within 16–32 km of the city centre. (4) In 1990, most of the rural residential areas were located north-northwest, southeast, and southwest of the People’s Square. By 2015, the areas southwest and southeast of the People’s Square became the focus of rural residential distribution. These findings provide a useful reference for future rural planning and construction.
Effect of Processing Conditions on the Microstructure, Mechanical Properties, and Corrosion Behavior of Two Austenitic Stainless Steels for Bioimplant Applications
Authors: Silva Mariana-Beatriz R. , Roche Virgine , Blanco Telma M. , Viet Nguyen Hoang , Balancin Oscar , Cabrera José-María , Jorge Alberto Moreira
Published: October 2020

Hot torsion tests were carried out to simulate the industrial thermomechanical processing of two austenitic steels for bioimplant applications, namely ISO 5832-9 and ASTM F138. The former has Ti, Nb, and V in the composition, being N-rich. However, the latter is Ni-richer and without extra alloying element additions. Special attention was paid to the effect of interpass times, particularly to the soaking temperature, which was reduced to decrease processing times and costs. Optical and electron microscopy, corrosion tests, and hardness measurements were used to characterize the effect of the above processing parameters on both alloys. No significant increase in processing loads was noticed after the reduction of the reheating temperature. This was explained in terms of the balance between partial particles dissolution and the increment in the solute drag effect provided by the elements put into solution. Such an increment in solid solution favored the dynamic recovery process, delaying the dynamic recrystallization one. However, strain-induced precipitation took place at lower temperatures, by using the extra N and Cr delivered to the matrix, and limiting the recrystallization softening. The rolling schedule promoted abundant grain refinement. The final grain size ranged from 2.5 to 11 µm, depending on reheating temperature, interpass time, presence of alloying elements, and N. In general terms, the corrosion resistance of the ISO steel soaked at the lowest temperature (1200 °C) was better than when reheated to the highest one (1250 °C). On the contrary, the F138 steel had worse corrosion behavior.