bluuebunny/crossref_metadata_2025 huggingface dataset:
THIOSTREPTON MODULATES TLR4 EXPRESSION AND INDUCES APOPTOSIS IN MDA MB 231 CELLS: AN IN VITRO AND IN SILICO ANALYSIS
Authors: Demırtaş Korkmaz Funda , Düzgün Zekeriya , Deveci Özkan Asuman
Published: September 2024

Objective: Toll-like receptors (TLRs) are key pattern recognition receptors involved in tumorigenesis, apoptosis, and metastasis. Triple-negative breast cancer (TNBC) is a highly aggressive malignancy with a poor prognosis. Although the role of TLRs in breast cancer remains underexplored, recent studies suggest targeting TLRs in TNBC could be beneficial. In this study Thiostrepton, an antibiotic and novel inhibitor of TLR7-9 in psoriatic inflammation, was investigated for its effects on TLR3, TLR4, and TLR9 expression in TNBC cells (MDA-MB-231).
Materials and Methods: The cytotoxicity of thiostrepton was assessed using the MTT assay. RT-PCR was used to measure gene expression levels of TLR3, TLR4, TLR9, Bax, Bcl-2, Nf-κB, and E-cadherin. Cell morphology changes were analyzed with Acridine Orange/Ethidium Bromide (AO/EtBr) staining. Molecular docking and dynamics simulations examined interactions between thiostrepton and the TLR4-MD-2 complex.
Results: Thiostrepton led to a concentration- and time-dependent decrease in cell viability. It significantly inhibited TLR4, Bcl-2 gene expression and increased TLR3, Bax, and Nf-κB levels. The changes in Bax and Bcl-2 gene expression, along with alterations in cell morphology, demonstrated that thiostrepton promoted apoptosis in MDA-MB-231 cells. While TLR9 expression reduction was not significant, thiostrepton notably increased TLR3 expression and decreased TLR4 expression. The three independent molecular dynamics simulations demonstrated that thiostrepton binds stably to the TLR4-MD2 domain, exhibiting a high binding affinity as indicated by the binding free energy calculations.
Conclusion: Thiostrepton effectively induces apoptosis and reduces cell viability in TNBC cells. In silico analysis suggest thiostrepton could modulate TLR4, highlighting its potential as a candidate for further research and therapeutic development.
MOLECULAR APPROACH TO PREMATURE EJACULATION: A PILOT STUDY ON S1P SERUM LEVELS AND S1PR1, S1PR2, S1PR3 POLYMORPHISMS
Authors: Turgut Coşan Didem , Güleç Gülcan , Çalış İbrahim Uğur , Danişman Sonkurt Melis , Ure İyimser , Mutlu Fezan
Published: September 2024

Objective: Sphingosine-1-phosphate (S1P) and its receptors are involved in various sexual functions, particularly in smooth muscle regulation and vascular responses. However, the role of S1P and its receptors in premature ejaculation (PE) remains unclear. This study investigates the relationship between single nucleotide polymorphisms (SNPs) in the S1PR1, S1PR2, and S1PR3 genes and plasma S1P levels in individuals with PE. Materials and Methods: The study included 100 individuals with PE and 100 healthy controls recruited from urology and psychiatry clinics. DNA was isolated from blood samples, and PCR was used to identify SNPs in the S1PR1 (rs2038366), S1PR2 (rs56357614), and S1PR3 (rs7022797) genes. Plasma S1P levels were measured using ELISA. Results: A significant association was observed between the heterozygous GT genotype of the S1PR1 gene and an increased risk of PE (OR 2.25, 95% CI 1.215–4.168, p = 0.0099). No significant associations were found between S1PR2 or S1PR3 polymorphisms and PE. Plasma S1P levels were significantly lower in the PE group (median 253.25 ng/L) compared to the control group (median 430.82 ng/L) (p < 0.001). Conclusion: S1PR1 gene polymorphism and reduced plasma S1P levels may be linked to the pathophysiology of PE. In contrast, S1PR2 and S1PR3 do not appear to be associated. Further research with larger samples is needed to confirm these findings.
Rússia X Ucrânia: análise dos impactos da guerra nos esportes
Authors: Filho Alexandre Ferreira Cruz , Gonçalves Artur Monteiro , Caldas Catarina Neves Baptista , Rêgo Lucas Becker de Moraes
Published: September 2024

The analysis of the Russia-Ukraine war focused on the conflict's effects on the global sports landscape, with particular emphasis on the socio- economic impacts experienced by Russia. The study highlights the sporting sanctions imposed on the country, which led to the exclusion of its athletes from international competitions such as the World Cup and the Champions League, as well as the cancellation of major sporting events, including the Formula 1 Grand Prix. Through a qualitative approach, the research examined the interrelationship between social and economic factors and the broader implications of these sanctions on Russia. Additionally, the study explored Russia's use of sports as a tool of soft power and the weakening of its sports diplomacy as a result of the sanctions imposed by the international community. The paper concludes that these sanctions reflect the growing geopolitical ramifications within the world of sports and suggests that enhanced global cooperation could provide a pathway to mitigating such conflicts.
A SALA DE RECURSO E O AEE: ESTRUTURAS E METODOLOGIAS DE APOIO À INCLUSÃO
Authors: da Silva Danyelli Baptista , Schon Gislaine , Hollenbach Josiela Trindade , de Souza Lidiane da Silva Rocha , Santos Maria Bethânia de Lima , da Silva Marisalva Alves , de Jesus Rafaella Freitas , Valadares Raquel Rocha Drews , Rodrigues Sibele Silva Leal , Santos Thays Cristina de Souza Freitas
Published: September 2024

O artigo aborda o papel das Salas de Recurso e do Atendimento Educacional Especializado (AEE) na promoção da inclusão escolar. As Salas de Recurso Multifuncionais são espaços estruturados com recursos pedagógicos e tecnológicos adaptados para atender às necessidades de alunos com deficiência, transtornos globais do desenvolvimento e altas habilidades/superdotação. O AEE complementa o processo educacional, oferecendo suporte individualizado e adaptado às necessidades dos alunos. O artigo destaca metodologias como adaptações curriculares, uso de tecnologia assistiva, atividades lúdicas e estratégias multissensoriais, ressaltando a importância da colaboração entre professores. Apesar dos desafios, como a falta de recursos e formação docente, as perspectivas para o fortalecimento da educação inclusiva são positivas, com avanços na conscientização e implementação de políticas públicas.
GUIA PARA ELABORAÇÃO DOS PROJETOS ARQUITETÔNICOS DE INSTITUIÇÕES DE LONGA PERMANÊNCIA – ILPIS
Authors: Sousa Filho Aloísio Evangelista de , Carvalho Ana Flávia Machado de
Published: September 2024

O processo de envelhecimento causa no homem transformações físicas e comportamentais ao longo da sua vida. Diante disso, conhecer as características da pessoa idosa e sua vivência se faz necessário para os profissionais que trabalharão com os mesmos, de forma direta ou indireta. No Brasil, o crescente aumento da população com mais de 60 anos tem causado mudanças no comportamento da sociedade em relação à forma como lidam com esse público, especialmente em relação à sua moradia. Em virtude desse aspecto tem ocorrido o aumento no número das Instituições de Longa Permanência para Idosos, as ILPIs. Locais que precisam ser projetados de forma adequada para proporcionar um acolhimento saudável favorecendo qualidade de vida para seus usuários. Perante o exposto, o presente estudo tem como objetivo a criação de um guia, em formato de website, destinado a arquitetos que pretendem elaborar projetos de ILPIs. Para sua elaboração serão consideradas as caracterizações da pessoa idosa e das Instituições de Longa Permanência existentes. No que concerne ao conteúdo do guia, este será composto pelos aspectos legais sobre a temática em questão, assim como materiais e métodos de construção que contribuam no conforto ambiental do usuário. Trata-se de um estudo de natureza tecnológica que poderá proporcionar a arquitetos uma otimização do tempo durante a elaboração dos projetos de ILPIs, bem como melhorar a qualidade de vida dos idosos institucionalizados. Embora existam definições a respeito das funções e obrigações relacionadas à Instituição de Longa Permanência, a crescente demanda e a influência dos aspectos negativos na vivência de idosos institucionalizados, tem tornado fundamental a busca pela reestruturação dessas edificações, a fim de colaborar ao bem-estar desse público. Diante do exposto, os resultados esperados estão relacionados à qualidade de vida da pessoa idosa institucionalizada através da construção de ambientes que atendam a todos os requisitos necessários para isso.
123. Jahresbericht des Zwinglivereins über das Jahr 2019
Authors: N. N.
Published: September 2024

No abstract available.
Matthias Neugebauer, Ulrich Zwinglis Ethik. Stationen – Grundlagen – Konkretionen, 2017
Authors: Engeler Judith
Published: September 2024

No abstract available.
Heinrich Bullinger: Briefe von Januar bis März 1547, 2019
Authors: Burnett Amy Nelson
Published: September 2024

No abstract available.
Barbara von Luternau, geborene von Roll (1502–1571): Was ihre Briefe an den reformierten Pfarrer Rebmann über ihr Leben und Wirken im altgläubigen Solothurn verraten
Authors: Grieder Monika
Published: September 2024

In the context of the Swiss revivalist movement (“Erweckungsbewegung”) and the beginning of the formation of Swiss national identity before 1848, Barbara von Roll, as was her maiden name, was rediscovered the ideal example of a woman who dedicated herself after becoming a widow, to nursing care by means of herbal medicine. The rediscovery of this aristocratic lady, who lived in the city of Solothurn at the time of the Reformation, happened in the context of transcribing her work, in particular seven letters addressed to Valentin Rebmann. The letters show, that the noble Barbara was not only a well-educated woman, but that she also owned medical skills and expertise that surpassed by far what was generally taught in the 19th century. This thesis presents the local-historical and religious context of the city of Solothurn as it was linked to the biography of Barbara von Luternau, her husband Hieronymus and other members of her family. Furthermore, all persons mentioned in Barbara’s letters will be introduced. The main focus is on the evaluation of the seven letters, emphasising the religious thinking as well as the social connections between the Roman-orthodox and the reformed people. Special attention will be drawn th the medical history to illustrate Barbara’s immense knowledge. Consequently, this bachelor thesis asks four research questions: first the biography of a noble woman who lived in a city, which became Roman orthodox after 1533, but had long been indecisive. That puts the biography in the wider context of ‘Women of the Time of the Reformation’. This rises the question of religious of religious freedom for married women in that time. Second, there is the question about the education, knowledge and professional activity of Barbara. Third, the social connections of families, family members and other persons. The fourth question asks, why Barbara von Luternau was rediscovered and presented as an ideal of womanhood not only in the 19th century but also in the Swiss women’s movement in the 20th century. This bachelor thesis is mainly based on historical data. Apart from Barbara’s seven letters, there are records from the city council of Solothurn, historical documents and letters which mention Barbara, medical books from Solothurn dating from the first half of the 16th century and from the Family Archive von Roll. Some of these sources have been transcribed and evaluated for the first time, thus revealing new biographical aspects of her and shedding light on the life in the context of reformation history of the city of Solothurn. By taking into consideration the limits of sources available, in particular with regard even to noble women, this thesis presents all the available data concerning Barbara von Luternau, ne´e von Roll.
Erich Bryner, "Den wahren Gott recht erkennen und anrufen": Der älteste Schaffhauser Katechismus von Johann Konrad Ulmer 1568/69, 2019
Authors: Henrich Rainer
Published: September 2024

No abstract available.
Dem Schwarzen Tod singend die Stirn bieten: Die bislang übersehene poetische Ader des Berner Dekans Johann Haller (1523–1575). Mit einem editorischen Anhang
Authors: Schiendorfer Max
Published: September 2024

In the historical reconstruction of early modern conditions, different kinds of sources such as chronicles, diaries, letters or various archival documents have always been considered to be standard fare. But more inconspicuous testimonies such as keyword-like calendar notes recorded for personal use or literary documents such as song texts, on the other hand, have usually received less attention. This article shows that the evaluation of such supposedly less relevant source material can lead to interesting new insights as well. With the example of three songs from the years 1563 to 1568, signed with the initials J. H. and kept as unique specimens in three different libraries, it is shown that they can be attributed to the well-known Bernese dean Johann Haller (1523–1575). As the publication dates already suggest, these songs are to be set against the historical background of the Black Death which struck all of Europe between 1563 and 1566. Obviously, the Bernese dean, who also had fallen ill with the plague and had been struggling with death for weeks, tried to poetically overcome his personal calamity with these songs. In the world of research, his traumatic near-death experience has not yet received the attention it deserves. For the first time now, Haller’s remarkable literary talent can be appreciated.
Utilization of Google Meet Application as Computer Learning Media during COVID-19 Pandemic
Authors: Yuri Jennifer , Crosbie Kho , Joanna Charvet
Published: September 2024

Learning media is very influential in the teaching and learning process during the COVID-19 pandemic, especially in computer subjects. However, there are still many who have knowledge of existing technology, especially in the use of the Google Meet application in learning media, and to make it easier for teachers to carry out computer learning, it is necessary to use the Google Meet application. The purpose of the study was to determine the benefits of the Google Meet application media on computer learning in high school. This research method uses Quantitative methods with survey models. The survey conducted in this study was online-based using the Google Form Platform. The results of this study explain that learning media using the Google Meet application can be used by teachers and students in helping and improving the teaching and learning process of students in computer courses, especially in high school. The conclusion of this study illustrates that the use of the Google Meet Application is very helpful for teachers and students in the atmosphere of the COVID-19 pandemic. The limitation of this study is that researchers only conducted research on the utilization of the Google Meet Application in Computer subjects, researchers hope that future researchers can conduct the same research but develop it in other subjects.
Ethics of Using Social Media for Learning: Encouraging Appreciation and Responsibility
Authors: Erwin Erwin , Dakhalan Andi Muhammad
Published: September 2024

In today’s era that is all about technology, social media is an important need for many people. Social media is now inherent in social circles, especially the current millennial generation. Almost all teenagers, adults and even children have social media. It is not uncommon for us to always be connected to the outside world through social media. The use of the internet through social media has presented a web forum that can form an online community. The purpose of the study is to find out the learning attitudes that can encourage students to use social media in learning in high school, as well as have a potential impact in encouraged, respectful and responsible attitudes in the use of social media as learning. The research uses a quantitative method that can be used to determine the results of research on student learning activities. The data was obtained from documents in the form of books and journals related to the theme, finally this research focused on encouraging students to social media as a form of attitude and responsibility in the world of Education. The results of these observations explain the ethics of using social media for learning in encouraging students to act respectfully and responsibly which can play an important role in encouraging the use of social media for students to be more concerned about their responsibilities. In this use, it is inseparable from an ability and a deficiency in the attitude of students if applied in learning, therefore educators and parents are very influential. The conclusion obtained from the study is that in encouraging the ethics of using social media today, social media has shown great hope in encouraging education. In this observation, the use of social media can be used as an attitude of respect and responsibility. With the use of social media, you can form good ethics to encourage mutual respect.
Enhancing Speaking Skills Through Role Play and Multimedia Technology
Authors: Ridayani Ridayani , Purwanto M Bambang
Published: September 2024

This study explores and evaluates the effectiveness of integrating roleplay methods and multimedia technology in improving students' English-speaking skills in the hospitality industry. Using an action research approach, this study was conducted among third-semester by totalling sampling 30 students majoring in travel business at Prasetiya Mandiri Polytechnic Bogor. This research method includes three cycles of action: planning, action, observation, and reflection. In the planning stage, roleplay scenarios relevant to real situations in the hospitality industry are designed and combined with multimedia technologies such as video tutorials then participate in roleplay activities integrated with these multimedia elements. The results showed that integrating role play and multimedia technology significantly improved students' speaking skills. Students become more confident in using English, can communicate more effectively, and show improvement in pronunciation, intonation, and proper use of vocabulary. This study concludes that the integration of Role play with multimedia technology is a practical approach to improving English-speaking skills among hospitality students.
Upaya Meningkatkan Keterampilan Motorik Halus Anak Usia Dini Melalui Seni Melipat Kertas pada Kelompok A di TK Indiyasana Juwangen
Authors: Laku Maria Serlince L.
Published: September 2024

Keterampilan Motorik Halus Anak di TK Indriyasana Juwangen masih tergolong sangat rendah, dikarenakan media yang diberikan guru kurang menarik dan metode yang diberikan oleh guru lebih fokusnya ke LKA (lembaran kerja siswa) sehingga motorik halus anak belum berkembang secara optimal. Maka penulis menggunakan kegiatan seni melipat kertas Untuk meningkatkan keteraampilan Motorik Halus Anak. Rumusan masalah‘’Bagaimana seni melipat kertas dapat meningkatkan keterampilan motorik halus pada anak kelompok A TK Indriyasana Juwangen ?”. Tujuan penelitian ini untuk meningkatkan keterampilan motorik halus anak usia dini melalui seni melipat kertas pada anak kelompok A TK Indriyasana Juwangen. Jenis penelitian ini Penelitian Tindakan Kelas yang difokuskan pada situasi kelas atau Classroom Action Risearch. Alat pengumpulan data terdiri dari observasi dan dokumentasi. Teknik analisis data dengan cara reduksi data, display data dan verifikasi data. Dengan menggunakan analisis tersebut maka dapat penulis simpulkan hasil dapat dilihat dari adanya peningkatan kemampuan motorik halus anak pada tiap pertemuan
Peran Pendidikan Politik Terhadap Peningkatan Partisipasi Politik Generasi Muda dalam Pemilihan Presiden 2024
Authors: Firmanto Fakhry , Abadi Wilken Rezki
Published: September 2024

Penelitian ini bertujuan untuk menjelaskan partisipasi politik generasi muda dalam mempersiapkan pemilihan umum tahun 2024. Partisipasi politik ini dipengaruhi oleh beberapa faktor, mulai dari modernisasi, kelas sosial, intelektual, konflik elit, hingga keputusan politik. Faktor partisipasi politik menentukan kualitas elit politik yang akan memimpin negara di masa depan. Penelitian ini menggunakan pendekatan kualitatif dan kuantitatif, dengan pengumpulan data melalui studi literatur dan melalui kuesioner yang mempengaruhi pengaruh partisipasi politik bagi generasi muda terhadap pemilu. Penelitian ini menunjukkan bahwa peran generasi muda memiliki peran partisipasi politik yang cukup tinggi, yaitu sebagai upaya utama untuk mengubah peran negara menjadi lebih baik. Namun, yang perlu dipersiapkan saat ini bukan hanya melakukan sosialisasi dan edukasi politik tentang penggunaan hak pilih dalam pemilihan umum tahun 2024, tetapi yang lebih penting adalah pemahaman tentang orientasi dan proyeksi partai politik dan tokoh politik yang akan mengisi konstelasi negara yang lebih baik di masa depan.
Penerapan Legalisasi Dokumen Melalui Apostille Berdasarkan Permenkumham Nomor 6 Tahun 2022
Authors: Pradana Willy , Fakhry Fakhry
Published: September 2024

Indonesia telah mengaksesi Konvensi Apostille dengan dikeluarkannya Peraturan Presiden Nomor 2 tahun 2021, atas tindakan tersebut maka Indonesia tunduk terhadap segala aturan dalam Konvensi Apostille. Salah satunya yaitu tentang legalisasi dokumen asing. Proses legalisasi dokumen asing yang dahulu melalui proses yang rumit dan melalui banyak Lembaga pemerintahan seperti Kementrian Hukum dan HAM serta Kementerian Luar Negeri, kemudian diubah dengan menggunakan Apostille Certificated. Saat ini Pemerintah Indonesia belum menentukan “otoritas berwenang” yang akan menjalankan berkenaan dengan proses Apostille Certificated. Penelitian ini bertujuan untuk membahas mengenai penggunaan Apostille Certificated bagi dokumen publik yang sesuai dengan Konvensi Apostille yang berlaku di Indonesia, dan membandingkan penggunaan Apostille Certificated di negara lain. Penelitian ini dilaksanakan dengan menggunakan metode yuridis-normatif, dengan menyertakan beberapa contoh dari negara lain yang sesuai dengan pembahasan. Apostille Certificated senyatanya memberikan keuntungan yang sangat besar bagi Indonesia, untuk mendorong minat investasi internasional serta mempermudah setiap individu di negara anggota konvensi, terutama yang memerlukan pengakuan legalitas dokumen lintas negara.
Design and Fabrication of Bio-Inspired Robotic Systems for Developed Mobility and Functionality in Unstructured Environments
Authors: Abdulbaqi Azmi Shawkat , Alsultan Qusay Hatem , Nejrs Salwa Mohammed , Abd alla Israa Hussain , jabur Younus khalaf , Jassim Salah Ayad , Mohammed Mohammed kareem , Sulaiman Bahjat Hardan , Shawqi Omar Salah Al deen , Mohameed Othman jasim , Abed Tareq Hamad , Panessai Ismail@Ismail Yusuf , Khalaf Haitham Abbas
Published: September 2024

In turn, bio-inspired robotic systems have significantly contributed to the development of well-abled robots capable of moving and manipulating with ease in unknown environments. Imitating biological creatures in their mechanisms of adaptation and effectiveness of design gives these robots enhanced qualities of mobility, functionality, and resilience. In fact, major advances build on flexible joints, controlled underactuation, adaptive control, and sensory arrays of high quality, enabling these robots to traverse rough environments and perform high-precision operations inside the human body. For instance, snake-like robots should be able to move through narrow gaps and debris in some kind of search and rescue task much like a real snake, robotic fish can move effectively across underwater environments while monitoring water quality and marine life. These advancements in technology have broadened the sphere of application and effectiveness of robot applications, proving to be valuable tools in many areas, including disaster response, environmental monitoring, and space exploration. In this regard, one also realizes their significance due to the context of bio-inspired robots regarding the capability of data collection and analyses. The usual methods of data collection are generally limited in reach, recurrence, and resolution. Bio-inspired robots compensate for these inadequacies by continuously gathering various real-time data from environments not easily reachable for humans. More precise and detailed analysis of data resolution collected through these robots supports advanced techniques such as AI and machine learning. This is a very crucial capacity that is central to applications such as following wildlife, assessing the impacts of climate change, and monitoring pollution levels. The capacity of these robots to provide timely and accurate data ensures efforts in environmental management and conservation. The importance of bioinspired robotics, therefore, comes in the solutions associated with unstructured environments. Through the gains of nature, which have been exploited by evolution, these robots present new solutions that overcome the inability of classical robotic systems. The persistence in the performance and development of this field of science will provide ever-greater achievements, with very probably a very important role in the exploration, understanding, and interaction with the natural world played by bioinspired robotics.
Electrochemical Nitrogen Reduction: Towards Efficient Ammonia Production
Authors: Safour Raghada Azzam
Published: September 2024

This study focuses on electrochemical nitrogen reduction as a promising method for sustainable ammonia production. By utilizing electrochemical catalysis, nitrogen gas (N₂) is converted to ammonia (NH₃) under ambient conditions, significantly reducing energy consumption and harmful emissions compared to the traditional Haber-Bosch process. The research aims to develop new catalytic systems that enhance the efficiency and selectivity of nitrogen reduction, thereby addressing the environmental challenges associated with conventional ammonia production. Advances in catalyst design, reaction mechanisms, and the integration of renewable energy sources highlight the potential of this method to revolutionize the ammonia industry and contribute to global sustainability efforts.
Artist-led Spatial Production in the City: East Street Arts as Urban Activator
Authors:   , Ionita Catalina-Elena
Published: September 2024

This thesis investigates the potential of artist-led space to be an urban activator in response to the social, political, and economic challenges faced by urban environments in England in the 2020s. These challenges include the continuing rise in property development such as commercial investment, which generates low-quality, high density urban spaces, without concern for the negative impacts of gentrification on existing occupants such as exclusion and marginalisation. This trend has been exacerbated by central government austerity policies and top-down urban regeneration strategies. My research explores the potential urban activator role of arts organisations within the context of declining state recognition of arts and humanities, the persistent labour migration triggered by economic and political instability in the UK, and the growing shortfall in financial support from Local Authorities. The term ‘urban activator’ is used in academic discourse and refers to modest, often temporary interventions in urban settings aimed at promoting responsible development, enhancing community engagement, and reinforcing communal ownership of spaces (Atelier Kempe Thill, 2009; Bishop & Williams, 2012; Haydn & Temel, 2006; Pogačar, 2014; Rosa & Weiland, 2013; Spatial Agency, n.d.f). However, the correlation between urban activators and artist-led spaces remains unexplored in scholarly literature. This research addresses this gap, proposing a nuanced definition of artist-led spaces and their role as urban activators, using East Street Arts (ESA) as a case study. ESA is a recognised not-for-profit artist-led organisation that supports artists through initiatives embedded in local communities, particularly targeting diverse, lower-income areas to mitigate aggressive gentrification and raise climate change awareness. The thesis posits artist-led spaces as catalysts for change in economically and socially declining urban contexts threatened by dense development, advocating for growth that aligns with local identities and integrates into the community fabric. The research methodology incorporates embedded techniques including participant observations, interviews, archival research, mapping, and field journaling, drawing on the works of Michel de Certeau (1984), Doreen Massey (1994, 2005), Doina Petrescu (2010; 2017), Jeanne van Heeswijk (2007), and Jane Rendell (2020; 2010b). These methods emphasise the importance of ‘research by design’ and ‘designerly ways of knowing’ (Cross, 1982; Luxemburg, 2013; Mattern, 2016), positioning them as fundamental to the production of knowledge within this field. By examining artist-led spaces as critical agents in urban dialogues and as facilitators of diverse urban activations and community participation, this research contributes to the understanding of their potential role in addressing contemporary urban challenges.
Lula, o milagre
Authors: Wormser Gérard
Published: September 2024

Depois de dois meses de transição após a estreita vitória eleitoral de Lula no Brasil em 30 de Outubro de 2022, a invasão da Esplanada de Brasília lembrou ao novo governo que o jogo ainda não estava ganho. O ataque à sede das instituições federais esteve muito perto de ser bem sucedido. Esse cenário foi abortado assim que a polícia se submeteu ao comando. O fiasco das autoridades de Brasília levou à gestão dircta da segurança pelo governo e à demissão de centenas de funcionários públicos. A nossa análise tenta decifrar o que esse evento nos diz sobre as divisões de um país que duvida profundamente das suas instituições.
À la recherche de lignes dans la
nature
Authors: Ingold Tim
Published: September 2024

Les êtres
vivants ne se meuvent pas par déplacement latéral d’un corps solide d’un
point à un autre, mais par l’alternance de mouvements pousser-tirer,
semblables à ceux d’une tempête ou d’une tornade qui s’enroulent et se
déroulent pour se frayer un chemin à travers le ciel. Tous les êtres
sont alors comparables à des tourbillons dans le flux de la vie. En se
déplaçant, ils laissent des lignes ou des traces. Ensemble, ces lignes
s’entremêlent pour former un maillage. À l’inverse du réseau, dont les
lignes se connectent en points et en attaches, les lignes du maillage
sont nouées et forment ainsi une surface lisse et non striée, qui
s’apparente plus au feutre qu’à un tissu où se croisent chaîne et trame.
Ces lignes ne sont ni géométriques, ni organiques, mais plutôt
abstraites. Les lignes géométriques, allant de la corde tendue au rayon
de soleil, sont droites. Les lignes organiques sont le contour ou le
tracé d’une chose dès qu’elle est projetée sur une surface, mais elles
n’existent en rien dans la chose elle-même. Or les lignes du maillage
sont abstraites. Tel le courant de la rivière, ce sont les lignes qui
toujours slaloment, dans un monde entre ciel et terre.
Enhancing Cultural Consciousness
Authors: Willis Steve
Published: September 2024

Student engagement and empowerment promote active, first-person conversations with national and international scholars and artists through virtual presentations. The process discussed below establishes a procedure for student-directed learning and empowerment. This process can be applied to any publications, internet resources, videos, YouTube conversations, and so much more to develop multinarrative and multicultural learning opportunities. Active learning is evident in student reflections that were collected throughout the Fall 2020 semester. By accepting this process of empowering students through active, authentic learning, changes to the syllabus, curricula, and pedagogy had to be made. There is excitement about the potentiality presented by future students as they engage in a similar process of the analysis of chapters, ongoing Blackboard discussions, and how they approach encounters with scholars and artists through a virtual medium.
Not predetermined: ‘Fusion-Image’ and Multicultural Art Education Based on Sino-US Portrait Painting Project Practice
Authors: Chen Lei , Carter-Fisher Miguel
Published: September 2024

Students from three universities in China and the United States worked together on a portrait painting project called ‘Fusion-Image’. It is meant to get youths trading photos of their peers who live on different continents to make art. In addition to portraiture's ability to shed light on the human, emotional, and spiritual, 'Fusion-Image' goes beyond this to pique and address students' interest in various materials and techniques, including digital painting. At the study's conclusion, many participants expressed gratitude for allowing them to question and trouble previously held biases. The project is a practical experiment on artistic creation that may spark respect and tolerance, it illuminates art education in the context of social responsibility for cultural diversity. This has ramifications for the development of art curricula, for we believe that an attitude free of stereotypes in the classroom will produce more engaging and versatile pedagogical and scholastic outputs. The purpose of this article is to examine how art education for students of different cultures, ethnicities, and regions can help confront cross-cultural issues and, on this basis, enhance thinking about core issues in art, such as tradition, ideas, spirituality, times, and many other matters, based on the work of two art teachers in China and the USA.
Formação docente e o desafio da indução
Authors: Cruz Giseli Barreto da , Lahtermaher Fernanda
Published: September 2024

O artigo decorre de investigação delineada teórico-metodologicamente em torno de uma pesquisa-formação. Nele se objetiva analisar ações de indução docente mobilizadas no seio do processo investigativo com vistas à construção de políticas de formação de professores/as. A indução docente é assumida como apoio formativo sistemático ao docente que se encontra nos primeiros anos da carreira. A pesquisa-formação se inscreve no campo da narrativa enquanto atividade (auto)biográfica, conduzida pela aposta na troca entre pares como uma estratégia de partilha e enfrentamento das dificuldades que interpelam professores/as iniciantes no processo de socialização profissional. Participaram do estudo professores/as com até 5 anos de exercício profissional, vinculados a distintas redes públicas de ensino. A análise considerou a observação, registros de campo e narrativas produzidas pelos participantes. As constatações indicam que a pesquisa-formação se confirmou como um dispositivo profícuo de indução docente e de (trans)formação no processo de vivê-la coletivamente, posto que a formação por ela engendrada se traduziu em um percurso de reflexão intensa acerca dos aspectos facilitadores e dificultadores desse primeiro ciclo profissional.
Desigualdades de oportunidades educacionais
Authors: Soares Denilson Junio Marques , Dos Santos Wagner
Published: September 2024

O Índice de Oportunidades da Educação Brasileira (Ioeb) é um indicador que quantifica a contribuição de cada município ou Estado para o sucesso educacional de seus residentes. Esse índice é derivado de uma combinação ponderada de medidas de insumos e resultados, controlados pelo contexto familiar. Este artigo tem como objetivo analisar o algoritmo subjacente ao Ioeb, assim como os resultados obtidos pelos municípios do Espírito Santo, assumidos como unidades de análise. A pesquisa emprega uma abordagem metodológica mista, começando com uma fase qualitativa, por meio de pesquisa documental sobre o indicador, seguida por uma fase quantitativa, que inclui análises estatísticas descritivas e inferenciais. Os resultados revelam a complexa estrutura do algoritmo do Ioeb, alinhando-se com as metas estabelecidas pelo Plano Nacional de Educação para o decênio. As análises dos resultados educacionais no Espírito Santo demonstram uma significativa correlação com os resultados do Índice de Desenvolvimento da Educação Básica. Além disso, evidenciam disparidades marcantes na distribuição dos índices entre os municípios, apesar de avanços recentes. A microrregião Sudoeste Serrana destaca-se pelos melhores resultados educacionais, enquanto municípios nas extremidades norte e sul necessitam de melhorias substanciais para garantir o direito à aprendizagem, conforme preceitos constitucionais. Também se sinaliza para a elevada proporção de matrículas em municípios com limitadas oportunidades educacionais, incapazes de progredir no índice. Em face desses resultados, recomenda-se uma atenção especial por parte dos gestores e formuladores de políticas educacionais estaduais sobretudo a esses municípios, visando contribuir para o aprimoramento do sistema educacional no âmbito do estado.
Rankings acadêmicos na educação superior brasileira
Authors: Lourenço Henrique da Silva , Calderón Adolfo Ignacio , Wandercil Marco
Published: September 2024

Estudos demonstram que os rankings acadêmicos vêm se constituindo, no Brasil, como emergente campo de estudo, de caráter multidisciplinar, por meio de uma embrionária literatura científica em expansão, produzida por pesquisadores de diversas áreas do conhecimento preocupados pela compreensão da dinâmica de funcionamento desses instrumentos de avaliação externa. Este artigo se dedica ao estudo dos chamados rankings acadêmicos nacionais, tendo como objetivo compreender a trajetória do Guia do Estudante, umas das pioneiras tabelas classificatórias, na forma de rating de cursos e rankings de instituições de educação superior (IES), que existiu no Brasil durante trinta e dois anos (1986 – 2018). Partindo de uma perspectiva empírico racional, realizou-se análise bibliográfico-documental, tendo como referência quatro dimensões analíticas: (i) tipologia. (ii) funcionamento, (iii) metodologia e (iv) tendências predominantes. A pesquisa evidenciou uma trajetória marcada por cinco períodos: primeiros passos na classificação de cursos (1986 - 1990), classificação de cursos e também de IES (1991-2001), diversificação e instabilidade dos múltiplos ratings (2002-2008), aprimoramento metodológico e redução de tipos de ratings (2009-2015), e ênfase na transparência da metodologia e abrupto encerramento (2016-2018).
Expectativas e vivências acadêmicas posteriores de estudantes ingressantes no ensino superior
Authors: Eisenberg Zena , Almeida Leandro S.
Published: September 2024

Este artigo trata de um estudo longitudinal em que foram acompanhados 106 estudantes ingressantes no ensino superior por um período de seis meses. O objetivo foi verificar uma relação entre as expectativas com que estudantes ingressam e seu posterior bem-estar acadêmico, uma vez já cientes de seu desempenho acadêmico no primeiro período de curso. Para avaliar as expectativas dos estudantes, usou-se a Escala Brasileira de Expectativas Acadêmicas para Ingressantes no Ensino Superior e, para avaliar o bem-estar, foi utilizado o Questionário de Vivências Acadêmicas na versão reduzida. Os resultados apontam para uma vivência de curso e carreira mais positiva entre aqueles estudantes com maiores expectativas de qualidade do desenvolvimento acadêmico. Além disso, as vivências pessoais foram mais positivas entre estudantes que tinham altas expectativas para estudar fora do país por algum período de tempo. Outro resultado que se destacou foi a diferença entre estudantes que pretendiam continuar no curso e aqueles que não pretendiam ao final do primeiro período de curso: os que desejavam permanecer tiveram vivências mais positivas nos quesitos institucional, curso e carreira e interpessoal. Concluímos que às instituições de ensino superior cabe investir no apoio institucional, incluindo orientação de curso e carreira, e na promoção de redes de apoio aos ingressantes. Faz-se necessário, para consolidar esses achados, repetir esse estudo com uma amostra mais ampla e representativa.
Desafios no combate ao plágio na comunidade científica
Authors: Lopes Thiago Beirigo , Costa Dailson Evangelista , Bracho Luis Andrés Castillo , Carneiro Raylson dos Santos
Published: September 2024

O plágio representa uma infração ética grave dentro do âmbito acadêmico, manifestando-se quando há apropriação de ideias, textos ou criações sem a devida atribuição ao autor original. Este estudo objetivou analisar a eficácia das estratégias editoriais empregadas por editores de periódicos científicos na prevenção e detecção do plágio, levando em consideração as diversas definições de plágio, seus variados tipos e as motivações que levam à sua ocorrência. Para esta pesquisa considera-se sete tipos de plágios, os quais são: plágio integral ou direto, plágio parcial ou indireto, plágio conceitual, plágio de fontes, plágio consentido, plágio por erro técnico e o autoplágio. Através da análise comparativa referente aos aspectos fundamentais (caracterização, detecção, motivações e implicações) das sete modalidades de plágio, identificou-se que, apesar das estratégias editoriais serem fundamentais no combate a esta prática contra os direitos autorais, estas enfrentam desafios significativos devido à complexidade do plágio e à constante evolução das técnicas empregadas para cometê-lo. A pesquisa conclui que a eficácia das estratégias é parcial, sugerindo a necessidade de uma abordagem mais holística que combine métodos educacionais, tecnológicos e políticas claras de prevenção.
Aportes empíricos, científicos e tecnológicos à editoração de uma revista científica de Educação
Authors: Araújo Marta Maria de , Ribeiro Cynara Teixeira
Published: September 2024

Tendo em vista o dossiê apresentado por um grupo de pesquisadores intitulado Editoração de periódicos científicos em Educação: tópicos contemporâneos, propusemo-nos refletir acerca da produção da gestão editorial de um periódico de educação específico para reconstituir pelo crivo do corpus da pesquisa, que combina as matérias dos editoriais da Revista com pesquisas quantitativas, as interdependências notórias e subjacentes e as variações das mudanças dessa produção no período de 2007 a 2023. Metodologicamente, o trabalho de cunho histórico assenta-se no entendimento da dimensão temporal de Elias (1994), especialmente por sua concepção da capacidade humana de relacionar sequências diferentes de mudanças, uma delas servindo de escala de referência para as outras. Em termos de conclusão, o corpus da pesquisa revela que a produção da gestão editorial é logicamente correlata às sequências das variações das mudanças qualitativas e quantitativas, que constituem alicerces para as suas interpendências.
Reliability of Girder Bridge System under Lateral Uneven Vehicular Overloads
Authors: Lang Liu , Yongqing Xia , Manfei Xu
Published: September 2024

Truck presence on bridges is random. Trucks may centrically or eccentrically appear on a bridge span in one or more lanes, which will cause extra load effects on girder components and eventually influence structural performance. Especially when trucks are heavily loaded, their eccentric passage is possible to induce damage in components, and, thus, the prescribed load- delivery path will be changed among components within the system. Therefore, component- and system-level structural performance of bridges subjected to aggressive vehicular overloads need to be thoroughly addressed. In this study, a WIM-based 5-axle overloaded truck model is chosen, and it is gradually applied to the finite element models of two girder bridges with different eccentric distance, considering two loading scenarios of single truck and multiple trucks. In detail, trucks are transversely loaded with an incremental eccentric distance, to investigate the impacts of eccentric loadings on structural performance, including failure sequences of components, load distribution factors among components, as well as system redundancy, as structures entering nonlinear stage. Finally, the reliability indices of the two bridges under uneven overloads are assessed at the component level and system level, respectively. The results of this study were beneficial to structural evaluation bridges subjected to overloads to ensure their serviceability and integrity.
Skin lesions recognition using federated and swarm learning: a case study in Chile
Authors:   , Romero Jofré Pamela Ignacia
Published: September 2024

El diagnóstico correcto de tumores y lesiones de la piel es de suma importancia. Los modelos de aprendizaje profundo (DL) se pueden utilizar como herramientas de diagnóstico en dermatología, ya que ayudan en el diagnóstico del cáncer de piel con resultados comparables al de los expertos. Para entrenar estos modelos de DL, se requiere una gran cantidad de datos y que estos sean diversos. Esto se convierte en una barrera para instituciones con escasos datos locales. Además, existe una creciente preocupación por los problemas de privacidad relacionados con el intercambio de datos. Este estudio busca evaluar el desempeño de modelos de DL (AlexNet, VGG, GoogLeNet, ResNet, Vision Transformer, y VMamba) en el diagnóstico de imágenes dermatoscópicas a través de 4 diferentes algoritmos de aprendizaje: Primero, el aprendizaje local, donde no se comparten datos ni parámetros del modelo. En segundo lugar, el aprendizaje central, en el que se comparten tanto los datos como los parámetros de los modelos. En tercer lugar, el aprendizaje federado, donde los parámetros se comparten, pero no los datos (un servidor central permite administrar y distribuir los parámetros). Finalmente se probó el aprendizaje de enjambre, donde se comparten los parámetros pero no los datos y no cuenta con un servidor central. El aprendizaje federado y de enjambre pueden permitir la colaboración entre diferentes instituciones, reduciendo los problemas de privacidad. Realizamos un análisis en 2 conjuntos de datos públicos provenientes del conjunto de datos del Hospital Italiano de Buenos Aires (HIBA), de Argentina, y en el conjunto de datos del International Skin Imaging Collaboration (ISIC). También se utilizó un tercer conjunto de datos no público con imágenes de nuestra institución (TRAWA-S). Desarrollamos dos métodos, el primero utilizando únicamente ISIC dividido en 3 conjuntos de datos (ISIC 1, ISIC 2, e ISIC 3) y el segundo, con los conjuntos de datos HIBA, ISIC y TRAWA-S. Las estrategias de aprendizaje federado y de enjambre mejoran los resultados de las métricas de desempeño (AUROC, AUPRC, accuracy y F1-score) en el conjunto de prueba con respecto al aprendizaje local en ISIC 1: 16%, 36%, 8.57%, y 31.71%; ISIC 2: 10%, 19%, 5.72%, y 22.41%; ISIC 3: 7%, 18%, 4.9%, y 18.61%; HIBA: 9%, 9%, 4.8%, y 11.22%; ISIC: 7%, 10%, 3.2%, y 6.46%; TRAWA-S: 5%, 9%, 5.6%, y 18.59%. A través del aprendizaje federado y de enjambre, se obtienen mejores resultados para predecir el tipo de lesión de la piel en conjuntos de datos locales. Estos algoritmos de aprendizaje ayudan a disminuir el sesgo y aumentar la variabilidad en el sistema.