bluuebunny/crossref_metadata_2025 huggingface dataset:
Faculty Scholarship at an Academic Health System
Authors: Jackson J. Brooks , Wendt Linder
Published: October 2022

Objectives: To determine the number of published papers per faculty member and percent of faculty with published papers during the FY 21 academic year at an allopathic medical school stratified by department, academic rank, sex, and academic track. Methods: Published papers from 449 tenure track faculty (351 males, 98 females) and 721 clinical track faculty (364 males, 357 females) were analyzed. Findings: 71.0% of tenure track faculty (69.5% of males, 76.5% of females) and 32.3% of clinical track faculty (39.3% of males, 25.2% of females) published a first/last author paper, and 88.6% of tenure track faculty (88.6% of males, 88.8% of females) vs 54.9% of clinical track faculty (60.7% of males, 49.0% of females) published an authored paper. The percentage of faculty publishing at least one first/last author paper stratified by academic rank was 59.4%, 45.8%, and 37.9% for Professor (61.8% of males, 52.5% of females), Associate Professor (51.0% of males, 37.3% of females), and Assistant Professor (47.3% of males, 28.7% of females), respectively. For tenure track faculty, the median number of published first/last author papers and total number of papers by sex was 1 and 4 for males, while it was 1.5 and 4 for females. For clinical track faculty, the median number of published first/last author papers and total number of papers by sex was 0 and 1 for males, and 0 and 0 for females. The three departments with the highest percentage of faculty with published papers were Urology, Neurosurgery, and Microbiology/Immunology. Conclusions: Tenure track faculty published more papers than clinical track faculty both in terms of quantity and in terms of percentage of faculty with authored papers. A greater percentage of male faculty published papers than female faculty in the clinical track but not the tenure track. Likewise, a greater percentage of faculty at higher academic ranks published papers.
Emerging Options Using Osteobiologics Treatment for FFP Type IA Comminuted Stable Fragility Fractures Involving the Pubic Rami
Authors: Ray James M.
Published: October 2022

Introduction: For many elderly patients who sustain a pubic rami fracture after a fall, the traditional treatment of extended bed rest and restricted mobility is often not practical. A classification for pubic rami fractures has been developed to recommend treatment. There is a technique to augment the biologic fracture environment using Calcium Phosphate through a minimally invasive procedure. In this study FFP Type Ia fractures were treated using Calcium phosphate. Methods: Our study, from January 1, 2018, to December 31, 2019, identified eighty-eight patients with FFP Type Ia fractures, who were treated with Calcium Phosphate. There were 9 males and 79 females, average ages were 78 and 86 respectively. Admission workup included pelvic x-rays as well as a CT scan. All received Calcium Phosphate for fracture fixation. They were followed in the outpatient clinic with pelvic radiographs at 3 weeks, 6 weeks, 6 months. 9 months and 1 year. Evidence of incorporation of the Calcium Phosphate in the fracture healing were documented. Results: There were no infections, no vascular, and no urological complications with this technique. All treated fractures went on to heal. Incorporation of the Calcium Phosphate was noted as early as 12 weeks. Residual presence of Calcium Phosphate was seen at 1 year and was consistent with the research literature. Conclusion: This new method of minimally invasive internal fixation using a bone biologic enhancement material provides an immediate improvement of post injury pain and an increase in immediate post treatment mobility. This treatment is applicable for all pelvic fragility fractures, including Type Ia who present with comminution. Risks with this treatment are low and benefits to the patient are high.
Family Functions during Adolescent Pregnancy: Cases Study
Authors: Sirikhun Banchamaporn , Virasiri Saovakon
Published: October 2022

Adolescent pregnancy is an overlapping situation during the normal development period for individuals and families, potentially causing impact and crisis as adolescents are not prepared both physically and psychosocially. The impacts could be more severe if the family does not accept the situation, rendering their functions incomplete or flawed, particularly in terms of caring, coping, socialization, and behavioral control in the hope to promote normal health and parenthood for pregnant adolescents. However, previous studies and most healthcare services emphasized evaluation primarily on the physical and mental health of pregnant adolescents, with limited focus on family functions. This three-case study thus endeavored to grasp family functions among families with adolescent pregnancy; by evaluating the health conditions of families with adolescent pregnancy both intentional and unintentional pregnancy. The content analysis revealed family emphasized the provision of financial support, conducted limited expression of love and care, and found no direct socialization on good parenting, inappropriate coping methods, and health issues among pregnant adolescents and families. Therefore, nurses and health personnel should create effective interventions to support and promote family health as a whole system; during adolescent pregnancy, postpartum care, raising their children, including strengthening new family.
High dietary and habitat diversity indicate generalist behaviors of northern bog lemmings Synaptomys borealis in Alaska, USA
Authors: Baltensperger AP , Hagelin JC , Schuette PA , Droghini A , Ott K
Published: October 2022

The northern bog lemming Synaptomys borealis (NBL) is a rare small mammal that is undergoing a federal Species Status Assessment (SSA) under the US Endangered Species Act. Despite a wide North American distribution, very little is known about NBL dietary or habitat needs, both of which are germane to the resiliency of this species to climate change. To quantify diet composition of NBL in Alaska, we used DNA metabarcoding from 59 archived specimens to describe the taxonomic richness and relative abundance of foods in recent diets. DNA analyses revealed a broad diet composed of at least 110 families and 92 genera of bryophytes (mosses and liverworts), graminoids, fungi, forbs, and woody shrubs. Nine bryophyte genera and Carex sedges composed the largest portions of NBL diets. To quantify habitat preference, we intersected 467 georeferenced occurrence records of NBL in Alaska with remotely sensed land cover classes and used a compositional analysis framework that accounts for the relative abundance of land cover types. We did not detect significant habitat preferences for specific land cover types, although NBL frequently occurred in evergreen forest, woody wetlands, and adjacent to water. Our research highlights the importance of bryophytes, among a high diversity of dietary components, and describes NBL as boreal habitat generalists. Results will inform the current federal SSA by quantifying the extent to which ecological constraints are likely to affect NBL in a rapidly changing boreal environment.
Take a Breath of Real-World Evidence
Authors: Fricker Janet
Published: October 2022

Allergen immunotherapy (AIT) in the form of subcutaneous or sublingual immunotherapy (SCIT/SLIT) is the only treatment for allergic rhinitis (AR) and/or allergic asthma with long-term efficacy.

Dr Fox considered the benefits for using real-world (RW) evidence in AIT. RW evidence provides the opportunity to explore a wide range of patients, estimate evolving risk benefits, and obtain data on clinical and economic value, as well as allowing comparisons of multiple alternative interventions. In clinical settings, such information allows doctors to provide allergy patients with the best advice, because most patients do not fit the narrow inclusion/exclusion criteria of clinical trials.

The benefits of RW research can be illustrated by two studies that are part of the Bringing Real-World Evidence to Allergy Treatment for Health (BREATH) programme, which was launched by Stallergenes Greer.

Prof Zielen provided an overview of the design of the German Birch AIT and French Grass SLIT Tablets RW studies. The studies are retrospective cohort studies based on IQVIA™ longitudinal prescription databases allowing patient follow-up. Follow-up was up to 9 years in Germany. Both studies share three objectives: looking at progression of AR after treatment cessation, initiation of new asthma medication in patients with AR (not asthma) at baseline, and progression of asthma medication use in patients with asthma (with or without AR at baseline).

Exploring the studies in greater detail, Prof Demoly presented the French Grass SLIT Tablets RW study, which compared 1,099 patients treated with SLIT with 24,475 controls not treated with SLIT. The results for the SLIT cohort versus the control cohort demonstrated long-term benefits for AIT (up to 2 years after treatment cessation), significantly reduced AR medication intake (p<0.001), significantly reduced asthma medication intake (p=0.003), and significantly decreased initiation of asthma medication (p=0.0013).

Prof Wahn presented the German Birch AIT RW study, which compared 9,001 AIT patients with 45,005 control patients not taking AIT. The results showed that AIT patients were significantly more likely to be AR medication-free (p<0.001), had reduced risk for initiation of asthma medication during the study (p=0.001), and were more likely to be asthma medication-free during 6 years of follow-up (p<0.001). Notably, when different types of AIT were compared to control, SLIT was not found to be any less effective than SCIT, opening the way for wider use of sublingual treatments.
The Intensity of Physical Activity in Asthmatic Children During Active Video Game Playing
Authors: Fernandes Barreto-Mendonça Juliana , Leal de Freitas Dantas Gomes Evelim , Muniz Cabral David Maisi , P. Basso-Vanelli Renata , Carvalho-Mello Maryjose , Costa Dirceu
Published: October 2022

Background: The use of virtual reality and video games has gained traction in physical rehabilitation medicine. In respiratory rehabilitation, their use is more recent, and for the application of this tool in this area it is necessary to examine the intensity of the effort reached in the activity. To evaluate the intensity of effort achieved in the ‘Reflex Ridge’ Xbox 360™ (Microsoft, Redmond, Washington, USA) game compared to the current gold standard treatment, the cardiopulmonary exercise test (CPET), in asthmatic children.

Methods: A cross-sectional study evaluating children participating in a CPET and the Reflex Ridge active video game (AVG), played using an Xbox 360 Kinect,TM over two different days.

Results: Thirty children who had a mean age of 7.86±1.9 years were evaluated. The maximum heart rate using the AVG reached 87% of the maximum predicted value and 93% of that obtained in the CPET. The intensity of the exercise using AVG reached 8.46±1.86 MET; this corresponded to 81% of the intensity reached in the CPET. There were no episodes of exercise-induced bronchospasm.

Conclusion: Using AVG can promote high intensity physical exercise. AVG playing may be considered a safe mechanism for the physical treatment of asthmatic children.
Well Known and Unknown Asthma Phenotype: Allergic Asthma
Authors: Bilge Öztürk Ayse , Can Sönmez Sadi , Göğebakan Emre , Pur Özyiğit Leyla , Çağlayan Benan
Published: October 2022

Allergic asthma is the most common phenotype of asthma and presents with various clinical subtypes and clusters, emphasising the importance of personalised treatments in its management. The disease has an IgE-mediated inflammatory course that may be triggered by many agents, such as pollens and nonsteroidal anti-inflammatory drugs. The allergic asthma patients are relatively young, with early-onset asthma and frequent exacerbations. The primary goal of this literature review is to provide a deeper insight into different patient groups and allergic asthma phenotypes, as well as to discuss treatment options accordingly. Triggering factors and clinical presentation of patient groups are also covered in this study.
Benthic graptolites from the Lower Silurian of the Western Sayan
Authors: Lykova E. V. , Sennikov N. V.
Published: October 2022

Dendroid graptolites of the Ona Formation from Lower Silurian of the Western Sayan have been studied. The collection is represented by very well preserved specimens. It includes only benthic forms and is characterized by the complete absence of planktonic taxa. This is extremely rare for graptolite communities. Representatives of dendroid graptolites have retained their lifetime shape. The unbroken shape of rhabdosomes may indicate calm sedimentation environments, since it is benthic dendroid graptolites that are very easily destroyed by underwater currents. Such type of autochthonous burial was previously studied by the authors on the territory of the Gorny Altai, and it is also known in the Lower Silurian of the Czech Republic.
Physical modeling of electrometric control of leaks from the pregnant solution pond
Authors: Kalganov A. S. , Olenchenko V. V.
Published: October 2022

The search for leaks from various hydraulic structures is a topical task of electrometry. Pregnant solution pond is one of the objects of electrometric control. They accumulate gold-enriched solutions. Identification of a breach in the waterproofing layer of a pond is possible by the method of electrical resistivity tomography with the measurement of induced polarization. Physical simulations were carried out to determine the nature of the electrical anomalies caused by the breach. A small plastic water tank imitated a solution pond. A hole was made in the bottom of the small tank, it provided a hydraulic connection with the large tank. The measurements were performed with the Skla-64 equipment, and the two-dimensional data inversion was carried out using the Res2DInv program. As a result, it was found that the place of leakage is allocated by an anomaly of low electrical resistivity and an intense anomaly of normalized chargeability. However, the 2D electrical resistivity model is complicated by inversion artifacts. The normalized chargeability anomaly is local and accurately marks the location of the leak in the bottom of the tank. It is proposed to use a complex analysis of electrical resistivity and normalized chargeability for electrometric monitoring of leaks from pregnant solution pond and other hydraulic structures.
Geoelectrical structure of the Selenginskaya basin based on 2D, 2D inversions of archival vertical electrical soundings data
Authors: Schekaeva E. A. , Neverdova N. N. , Sanchaa A. M.
Published: October 2022

In this article we present the results of the archival VES data interpretation carried out on the territory of the Selenga depression, based on 2D, 3D invsersions.
Aspects of the hydrocarbon accumulations distribution in the Bathonian regional reservoir (Western Siberia)
Authors: Kazanenkov V. A.
Published: October 2022

The paper considers the different aspects of the oil and gas presence in a specific reservoir in the top of the Middle Jurassic sequence of the West Siberian sedimentary cover. They allow to identify regional patterns of hydrocarbon accumulations distribution in the Yu2-Yu4 horizons of Bathonian reservoir within the entire territory of the West Siberian basin. Based on the latest results of the regional studies, the structural and facies control, trap type control have been established. Confinement to the certain parts of the reservoir section in various regions of the petroleum province have been described. Additionally changes in the hydrocarbons phase, pressure-and-temperature conditions, the physical and chemical properties of fluids have been identified. The revealed features of the oil-and-gas accumulations distribution make it possible to carry out a reasonable forecast of new findings in the Yu, Yu and Yu productive horizons within the promising areas. This is of great practical importance and application for the reserve replacement, as well as the effective selection of the future exploration strategy and further on the creation of the optimal development plan.
Conditions for the formation of the subcoal and supracoal units of the Yu1 horizon in the central and southern parts of the Pudino mesouplift
Authors: Kanakova K. I. , Aunova D. V. , Ibragimova S. M.
Published: October 2022

The work is devoted to the reconstruction of the formation conditions of the Yu1 horizon in the south of the Tomsk Region. The relevance and complexity of the problem lies in the fact that the deposits were formed in the zone of transition from marine to terrestrial, which affected the variegated lithofacies composition of the deposits and the complex geometry of sedimentary bodies. The study was based on the results of sedimentological analysis of the core, carried out by lithologists of the IPGG and the Tomsk State University, published in stock materials, as well as well logging data for 217 wells.
PELATIHAN ADMINISTRASI PEMERITAHAN KELURAHAN BERBASIS ONLINE DI KECAMATAN NAMBO KOTA KENDARI TAHUN 2022
Authors: Sartono Sartono , Muhammad Elwan La Ode , Yusuf Muhammad , Taufik Taufik , Aslim La Ode
Published: October 2022

Community service activities integrated with thematic Real Work Lectures (KKN) of Halu Oleo University aim to contribute to the government and citizens, especially in public services in the midst of the New Normal period in Southeast Sulawesi. This activity is an online-based Urban Village Administration Training in Nambo District, Kendari City, Southeast Sulawesi Province. The method used in the Thematic KKN is carried out directly at the activity location. Students are active from the beginning to the end of KKN activities carried out in the domicile area. The results of community service activities through Thematic KKN for students provide information that the average village government apparatus does not yet know and understand how to use internet technology facilities in public services, especially in managing village administration online based. There is only 1 website in the sub-district and all kelurahan do not yet have a website. There has never been any technical training on website management for village officials. Local government support is very limited in providing resources in realizing online-based urban administration.
Місто Єлисаветград напередодні Першої світової війни: історико-статистичний огляд
Authors: Тимошенко Володимир
Published: October 2022

Історична урбаністика займає одне із чільних місць у сучасній історичній науці. Вивчення історії міст є запорукою розуміння не лише їхнього розвитку та особливостей життя міського населення, а й дозволяє визначати вплив того чи іншого міста на історичний поступ цілих країв або регіонів. У пропонованій публікації автор узагальнив історико-статистичні дані стосовно адміністративно-територіального, соціально-економічного та культурного становища міста Єлисаветграда напередодні Першої світової війни. Джерельна база дослідження представлена спогадами містян, статистичними щорічниками, адрес-календарями, довідковими, енциклопедичними виданнями та картами 1911-1913 рр. Стаття буде цікавою для фахівців, що займаються проблемами історичної урбаністики, повсякденної історії, мікроісторії та історичного краєзнавства.
Римо-католицькі спільноти Дніпропетровщини у другій половині 1940-х років
Authors: Мосюкова Наталія
Published: October 2022

У перші повоєнні роки на Дніпропетровщині існували дві римо-католицькі громади — у Дніпропетровську та Дніпродзержинську. Вони відновили свою діяльність (після репресій 1930-х років) ще у часи німецької окупації. Аналіз документів, які є в наявності, але не дають повної інформації, показав, що спільноти були подібні за своєю чисельністю, національною та віковою ознакою.

В умовах певної лібералізації відносин між державою та релігійними організаціями, римо-католики плекали надію на продовження своєї діяльності і після повернення радянської влади на українські землі. Держава ж усіляко перешкоджала повноцінному існуванню парафій, здійснювала фінансовий тиск на них, у результаті спільнота Дніпропетровська була змушена відмовитися від претензій на костел (громада Дніпродзержинська зустрічалася у приватному приміщенні). Спільноти знаходилися під наглядом влади, протягом другої половини 1940-х років тиск на релігійні організації посилювався.
Methods of struggle of the Russian Black Hundreds against Ukrainians in the prisoner-of-war camps in Austria-Hungary and Germany (1914-1917)
Authors: Sribnyak Ihor , Yakovenko Natalia , Matviyenko Viktor
Published: October 2022

The article is aimed at analyzing forms and methods of struggle of the Russian Black Hundreds against Ukrainian activists of the tsarist army in the prisoner-of-war camps on the territory of Austria-Hungary and Germany (Freistadt, Rastatt, Wetzlar, Salzwedel), being ukrainized at the end of 1914-1915, which was accompanied by the removal of ethnic Russians from those camps.

The research novelty of the article lies in the objective evidence of those factors that initially made it almost impossible to carry out cultural and educational work among captured Ukrainians, as well as the reconstruction of the process of gradual overcoming by the camp residents of their non-acceptance of national liberation slogans and the idea of Ukrainian independence.

Conclusions: It is proved that despite various methods of intimidation (physical violence against Ukrainian activists, destruction of books and magazines, boycott of schools, anonymous leaflets of threatening content, writing down registration numbers of prisoners, etc.), the Black Hundreds did not succeed in preventing the activities of cultural and educational circles created in the camps by the Union for the Liberation of Ukraine (ULU). In a short time, the majority of camp residents joined Ukrainian organizations in the camps, which enabled to minimize the influence of anti-Ukrainian forces. So Ukrainians managed to overcome their centuries-old fear of tsarist despotism, which constrained their ideas and actions with the threat of inevitable punishment. Their desire to gain as much knowledge as possible in conditions of captivity, their readiness to acquire new skills and abilities that they might need during civilian life – suppressed all frightening efforts of the Black Hundreds. It became possible to achieve because of the involvement of captured Ukrainian officers into national organizational activities. Thanks to this, thousands of Ukrainians devoted to the cause of national liberation were brought up in the camps, ready for the armed defense of Ukraine against the Bolshevik invasion.
PENGGUNAAN N-MERS FREQUENCY DAN ALGORITMA AGNES UNTUK PEMBENTUKAN POHON FILOGENETIK PADA VIRUS MEMATIKAN
Authors: Khoirul Umam  , Riad Taufik Lazwardi
Published: October 2022

Every organism has DNA (deoxyribonucleic acid) which carries genetic information. One of the methods for analyzing strings of DNA sequences is n-mers frequency. It is a data mining method on strings of DNA sequences that is converted into numerical data. We studied 13 deadly viruses, consisting of Rabies, HIV, Ebola, Smallpox, Marburg, Herpes B, Lujo, Avian Influenza, Spanish Flu H1N1, Dengue, HPV, SARS-CoV, and SARS-CoV-2. This study aims to establish the phylogenetic tree and find out the genetic relationship of the deadly viruses. The first method we used are collecting viral DNA sequences from the NCBI database. Afterward, the strings of DNA sequences were converted into numerical data using the n-mers frequency. After that, the dissimilarity matrix was calculated and the phylogenetic tree was established using the AGNES algorithm. Based on the phylogenetic tree, the aforementioned 13 viruses were classified into three clusters, namely cluster 1 from the realm Riboviria, cluster 2 from the realm Duplodnaviria and cluster 3 from the realm Varidnaviria. The clustering results of 13 viruses are valid because each virus is clustered based on its taxon. In addition, viruses that have the closest genetic relationship are grouped first, while viruses that have the distant genetic relationship are grouped later.
PENINGKATAN MANAJEMEN PEMASARAN MELALUI DESAIN KEMASAN
Authors: Adisthy Shabrina Nurqamarani  , Ari Juliana  , Setyo Kuncoro  , Nadia Nurani Isfarin  , Deddy Juniadi
Published: October 2022

Usaha Mikro, Kecil, dan Menengah (UMKM) merupakan pilar terpenting dalam perekonomian Indonesia. Bagaimanapun, seringkali UMKM mengalami kendala dalam hal memasarkan produknya. Beberapa faktor menjadi penyebab kendala dalam hal pemasaran produk diantaranya kualitas, finansial, tidak ada target pasar yang jelas hingga kemasan yang tidak menarik dan tidak memuat informasi tentang kandungan produk. Mitra program pengabdian masyarakat ini merupakan UMKM yang baru merintis usahanya di bidang penyedia bahan baku herbal yang mengalami kendala terkait terbatasnya pengetahuan terkait branding dan pentingnya kemasan yang menarik bagi konsumen serta penggunaan tools dan teknologi dalam membuat desain kemasan yang unik dan mewakili identitas merek. Adapun untuk mengatasi kendala tersebut, solusi yang ditawarkan adalah pelatihan desain label kemasan untuk meningkatkan kapasitas dan kemampuan mitra dalam memanfaatkan teknologi untuk menghasilkan kemasan yang menarik dan mempunyai identitas merek. Strategi pemasaran merupakan salah satu komponen penting dalam keberhasilan usaha, tapi banyak pelaku usaha yang mengabaikan hal tersebut. Label dan kemasan merupakan salah satu komponen dari pemasaran pada aspek produk yang dapat meningkatkan minat beli customer dan juga nilai jual produk. Penelitian menunjukkan kemasan yang baik akan meningkatkan nilai jual produk lebih dari 40% dari harga awal dan tampilan grafis yang menarik dan memuat informasi yang memadai menjadi representasi dari produk yang ditawarkan. Berdasarkan hal tersebut, kami merancang program pengabdian masyarakat dengan salah satu kegiatannya yaitu pelatihan desain label menggunakan Canva dan Freelogomaker. Dalam program abdimas ini, dibagi menjadi 4 tahapan mulai dari persiapan, pelaksanaan, monitoring evaluasi, serta pelaporan. Hasil dari kegiatan ini, mitra dapat membuat logo dan mendesain kemasan secara mandiri. Selain itu, mitra juga mendapatkan peningkatan pengetahuan terkait branding dan visual identity yang tepat dan menarik konsumen. Dari hasil pelatihan, mitra dapat membuat desain kemasan yang lebih menarik dari sebelumnya, memuat informasi yang memadai dan merepresentasikan produk yang ditawarkan (produk herbal). Berdasarkan hasil survey kepuasan mitra, mitra merasa puas dengan kegiatan pengabdian masyarakat yang diberikan.
PEMANFAATAN PEKARANGAN SEBAGAI RUMAH PANGAN LESTARI DI RT 05 DESA PRAMBATAN LOR KABUPATEN KUDUS
Authors: Dian Ratu Ayu Uswatun Khasanah  , Aini Indriasih  , Yuli Haryati  , Einstivina Nuryandari  , Edi Prayitno  , Ismartoyo
Published: October 2022

Ketahanan pangan (Food Security) telah menjadi isu global. Terpenuhinya pangan bagi setiap rumah tangga merupakan tujuan sekaligus sebagai sasaran dari ketahanan pangan yang ada di daerah maupun secara nasional. Hal tersebut dapat dilakukan dari pemantapan ketahanan pangan di tingkat keluarga dengan mewujudkan kemandirian pangan keluarga. Kemandirian pangan keluarga dilakukan dengan memanfaatkan pekarangan rumah. Pekarangan adalah taman rumah tradisional yang bersifat pribadi. Pemanfaatan lahan pekarangan untuk ditanami tanaman kebutuhan keluarga sudah dilakukan masyarakat sejak lama. Permasalahan terjadi ketika semakin berkurangnya luas pekarangan. Semakin sempitnya lahan mengakibatkan minat dan perhatian warga untuk meneruskan budaya memanfaatkan pekarangan semakin berkurang dan bahkan dilupakan. Untuk mengatasinya, diperlukan strategi yang sistemik dan sistematis untuk menghidupkan kembali budaya tersebut. Diperlukan upaya re-aktualisasi untuk menggerakkan kembali budaya menanam di lahan pekarangan tanpa mempertimbangkan luas lahan. Kegiatan PkM bertujuan untuk Meningkatkan kondisi sosial ekonomi warga dengan menyisihkan sedikit waktu dan tenaga untuk mengolah pekarangan menjadi sumber ketahanan pangan keluarga. Mengubah budaya warga yang mementingkan pendapatan dari hasil kerja dengan memanfaatkan pekarangan menjadi sumber pendapatan setiap saat melalui pengembangan model Rumah Pangan Lestari. Kegiatan dilakukan di Desa Prambatan Lor kecamatan Kaliwungu kabupaten Kudus. Tahapan kegiatan: 1) survei lokasi/perijinan, 2) Pelatihan secara teori 3) pelatihan secara praktek dan 4) monitoring dan evaluasi. Hasil monitoring tananam sayuran mulai tumbuh. Adapun lele dalam taraf pertumbuhan ikan.
RETRACTED: Improving the melting performance in a triple-pipe latent heat storage system using hemispherical and quarter-spherical fins with a staggered arrangement
Authors: Abed Azher M. , Mohammed Hayder I. , Patra Indrajit , Mahdi Jasim M. , Arshad Adeel , Sivaraman Ramaswamy , Ibrahem Raed Khalid , Al-Qrimli Fadhil Abbas , Dhahbi Sami , Talebizadehsardari Pouyan
Published: October 2022

This study aims to evaluate the melting characteristics of a phase change material (PCM) in a latent heat storage system equipped with hemispherical and quarter-spherical fins. A vertical triple-pipe heat exchanger is used as the PCM-based heat storage unit to improve the melting performance compared with a double-pipe system. Furthermore, the fins are arranged in inline and staggered configurations to improve heat transfer performance. For the quarter-spherical fins, both upward and downward directions are examined. The results of the system equipped with novel fins are compared with those without fins. Moreover, a fin is added to the heat exchanger’s base to compensate for the natural convection effect at the bottom of the heat exchanger. Considering similar fin volumes, the results show that the system equipped with four hemispherical fins on the side walls and an added fin on the bottom wall has the best performance compared with the other cases with hemispherical fins. The staggered arrangement of the fins results in a higher heat transfer rate. The downward quarter-spherical fins with a staggered configuration show the highest performance among all the studied cases. Compared with the case without fins, the heat storage rate improves by almost 78% (from 35.6 to 63.5 W), reducing the melting time by 45%.
Numerical study of the thermally stratified hemodynamic nanofluid flow with variable viscosity over a heated wedge
Authors: Akbar Noreen Sher
Published: October 2022

We analyze the steady laminar incompressible boundary-layer magnetohydrodynamic impacts on the nanofluidic flux over a static and mobile wedge in the existence of an applied magnetic field. The Falkner–Skan wedge flow model is taken into consideration. Reynolds’ model is considered to introduce temperature-dependent viscosity. As in real life, most fluids have variable viscosity. The executive partial differential equations are converted into a set-up of ordinary differential equations by means of a similarity conversion. Numerical solutions are computed for the converted set-up of equations subjected to physical boundary conditions. The specific flow dynamics like velocity profile, streamlines, temperature behavior, and coefficient of local skin friction are graphically analyzed through numerical solutions. It is concluded that the laminar boundary-layer separation from the static and moving wedge surface is altered by the applied external electric field, and the wedge (static or moving) angle improves the surface heat flux in addition to the coefficient of skin friction. Furthermore, it is found that the methanol-based nanofluid is a less-efficient cooling agent than the water-based nanofluid; therefore, the magnitude of the Nusselt number is smaller for the water-based nanofluid. It is also observed that the addition of only 1% of these nanoparticles in a base fluid results in an enhancement of almost 200% in the thermal conductivity.
Risk of loss of tourism attractiveness in the Western Mediterranean under climate change
Authors: Agulles Miguel , Melo-Aguilar Camilo , Jordà Gabriel
Published: October 2022

The sun and sea tourism is key for economy of the southern European countries. This economic sector is expected to be severely affected by climate change due to the projected loss of beaches, loss of thermal comfort, water restrictions or extreme events, among other impacts. Thus, adaptation strategies need to be developed urgently. To do so, it is necessary to first conduct an assessment of the risk of loss of tourism attractiveness to guide the development of such strategies. Furthermore, uncertainties in the different factors are considered into the risk analysis. In this study we analyze the risk of loss of tourism attractiveness due to climate change in the Spanish Mediterranean destinations, in the Western Mediterranean, as a case study. To do so, the Vulnerability Sourcebook methodology is adopted and modified to incorporate the uncertainties in the different elements of the impact chains. The increase in heat stress and the loss of beach availability have been identified as the climate change induced hazards that will affect the most the region attractiveness. Also, the impact chains have been constructed and several climatic and socioeconomic indicators have been considered after a knowledge co-production process with selected stakeholders. The weights assigned to each indicator have been obtained from an analytic hierarchy process based on the results of a consultation with sector experts. The results of the impact chain operationalization have shown that exposure and vulnerability in all the touristic destinations in the region are very similar and that the hazard will largely increase in the next decades, specially under the future scenario SSP585 or the RCP8.5. However, the final risk does not seem to suffer a large increase because of the relatively small weight assigned to the hazard. In other words, the exposure (e.g., typology of the tourists and touristic activities) or the vulnerability (e.g., capacity to put in place adaptation strategies) would be more important than the projected change in the hazard (e.g., heat stress increase or beach reduction). The benefits and limitations of the methodology are discussed and some suggestions for the validation of the assessment are proposed.
Case report: Percutaneous adrenal arterial embolization cures resistant hypertension
Authors: Zhou Yaqiong , Wang Dan , Liu Qiting , Hou Jixin , Wang Peijian
Published: October 2022

Background

Primary aldosteronism is a common cause of resistant hypertension. Patients with primary aldosteronism due to aldosterone-producing adenoma are generally treated with unilateral adrenalectomy or medical therapy. Superselective adrenal arterial embolization is an alternative treatment for patients with unilateral primary aldosteronism.

Case summary

We present a 39-year-old male patient with a 5-year history of primary aldosteronism and secondary hypertension. The patient refused adrenalectomy while accepted pharmacotherapy. Despite taking adequate dose of spironolactone, the patient experienced repeatedly muscle weakness due to hypokalemia and had poor blood pressure control with left ventricular hypertrophy and renal dysfunction. Aldosterone-producing adenoma in the left adrenal gland was confirmed by computerized tomography and adrenal venous sampling. The left middle adrenal artery, which was confirmed to provide the main arterial supply to the aldosterone-producing adenoma, was embolized by injecting 2 ml ethanol. The embolization normalized his blood pressure for up to 3 months and reversed left ventricular hypertrophy.

Conclusion

Superselective adrenal arterial embolization could be an alternative treatment for patients with aldosterone-producing adenoma who refuse adrenalectomy.
Case report: Remedial surgical treatment of aorto-duodenal fistula with infected aneurysm after endovascular aortic repair
Authors: Li Wen-Dong , Wu Guang-Yan , Song Bin , Zhao Jie , Li Xiao-Qiang , Zhou Min
Published: October 2022

Aorto-duodenal fistula (ADF) is a rare cause of upper gastrointestinal bleeding, but it is associated with high mortality. It usually occurs in patients with prior aortic surgery or who have undergone aortic graft placement. Abdominal aortic aneurysm (AAA) might be a cause of primary ADF, which could develop into sudden shock. Because ADF is difficult to diagnose, surgery to correct it has a poor outcome. We here report the successful treatment of an ADF complicated with infected AAA after endovascular repair of a ruptured aneurysm of the iliac artery.
Heart failure and cancer: From active exposure to passive adaption
Authors: Du Yantao , Wu Tao
Published: October 2022

The human body seems like a “balance integrator.” On the one hand, the body constantly actively receives various outside stimuli and signals to induce changes. On the other hand, several internal regulations would be initiated to adapt to these changes. In most cases, the body could keep the balancein vitroandin vivoto reach a healthy body. However, in some cases, the body can only get to a pathological balance. Actively exposed to unhealthy lifestyles and passively adapting to individual primary diseases lead to a similarly inner environment for both heart failure and cancer. To cope with these stimuli, the body must activate the system regulation mechanism and face the mutual interference. This review summarized the association between heart failure and cancer from active exposure to passive adaption. Moreover, we hope to inspire researchers to contemplate these two diseases from the angle of overall body consideration.
Environmental wellbeing in the context of sustainable development: Evidence from post-communist economies
Authors: Ulman Simona-Roxana , Mihai Costica , Cautisanu Cristina , Brumă Ioan-Sebastian , Coca Oana , Stefan Gavril
Published: October 2022

Considering diverse national contexts, there are differences in the capacity of countries in terms of their ability to attain sustainability in its three main dimensions. The present study puts the economic, social, and environmental indicators face-to-face from 19 post-communist economies across the 2006–2020 period. It emphasizes the main vulnerabilities at the level of the analyzed countries, concentrates on these weak points, and offers concrete explanations regarding the main social and economic factors, exerting a negative influence on them. Consequently, placing climate and energy, with their major components, i.e., energy use, energy savings, greenhouse gases, and renewable energy, at the center of the analysis, as the major weak points of environmental wellbeing within the analyzed group of countries, the nature of the influence of human and economic wellbeing upon each of them is evidenced using panel data-specific methods (pooled, fixed, and random effects). The general results obtained showed the following: 1) the components of environmental wellbeing registered a different evolution among post-communist economies; 2) climate and energy components were the main vulnerabilities in terms of environmental sustainability; 3) these environmental components were closely linked to both components of economic and social dimensions; and 4) the determinants of energy use, energy savings, greenhouse gases, and renewable energy were different in the selected group of countries. This study draws attention to the fact that the patterns of development applied in the group of post-communist economies seem to strengthen sustainable goals, especially with regard to economic and human wellbeing. Moreover, while directing its focus on the main urgent environmental vulnerabilities and encouraging their strengthening by not putting the economic dimension in the center of interest, it supports the theoretical perspective of sustainable wellbeing, based on sustainability and ecological economics.
Resveratrol biosynthesis, optimization, induction, bio-transformation and bio-degradation in mycoendophytes
Authors: Abo-Kadoum M. A. , Abouelela Mohamed E. , Al Mousa Amal A. , Abo-Dahab Nageh F. , Mosa Mohamed A. , Helmy Yosra A. , Hassane Abdallah M. A.
Published: October 2022

Resveratrol (3,4,5-trihydroxystilbene) is a naturally occurring polyphenolic stilbene compound produced by certain plant species in response to biotic and abiotic factors. Resveratrol has sparked a lot of interest due to its unique structure and approved therapeutic properties for the prevention and treatment of many diseases such as neurological disease, cardiovascular disease, diabetes, inflammation, cancer, and Alzheimer’s disease. Over the last few decades, many studies have focused on the production of resveratrol from various natural sources and the optimization of large-scale production. Endophytic fungi isolated from various types of grapevines and Polygonum cuspidatum, the primary plant sources of resveratrol, demonstrated intriguing resveratrol-producing ability. Due to the increasing demand for resveratrol, one active area of research is the use of endophytic fungi and metabolic engineering techniques for resveratrol’s large-scale production. The current review addresses an overview of endophytic fungi as a source for production, as well as biosynthesis pathways and relevant genes incorporated in resveratrol biosynthesis. Various approaches for optimizing resveratrol production from endophytic fungi, as well as their bio-transformation and bio-degradation, are explained in detail.
CodY is modulated by YycF and affects biofilm formation in Staphylococcus aureus
Authors: Wu Shizhou , Qin Boquan , Deng Shu , Liu Yunjie , Zhang Hui , Lei Lei , Feng Guoying
Published: October 2022

Background

Staphylococcus aureus (S. aureus) is the leading cause of various infective diseases, including topical soft tissue infections. The goals of this study were to investigate the roles of YycF and CodY in the regulation of biofilm formation and pathogenicity.

Methods

Electrophoretic mobility shift assay (EMSA) was conducted to validate the bound promoter regions of YycF protein. We constructed the codY up-regulated or down-regulated S. aureus mutants. The biofilm biomass was determined by crystal violet microtiter assay and scanning electron microscopy (SEM). Quantitative RT-PCR analysis was used to detect the transcripts of biofilm-related genes. The live and dead cells of S. aureus biofilm were also investigated by confocal laser scanning microscopy (CLSM). We constructed an abscess infection in Sprague Dawley (SD) rat models to determine the effect of CodY on bacterial pathogenicity. We further used the RAW264.7, which were cocultured with S. aureus, to evaluate the effect of CodY on macrophages apoptosis.

Result

Quantitative RT-PCR analyses reveled that YycF negatively regulates codY expression. EMSA assays indicated that YycF protein directly binds to the promoter regions of codY gene. Quantitative RT-PCR confirmed the construction of dual- mutant stains codY + ASyycF and codY-ASyycF. The SEM results showed that the biofilm formation in the codY + ASyycF group was sparser than those in the other groups. The crystal violet assays indicated that the codY + ASyycF group formed less biofilms, which was consistent with the immunofluorescence results of the lowest live cell ration in the codY + ASyycF group. The expression levels of biofilm-associated icaA gene were significantly reduced in the codY + strain, indicating codY negatively regulates the biofilm formation. Furthermore, CodY impedes the pathogenicity in a rat-infection model. After cocultured with bacteria or 4-h in vitro, the apoptosis rates of macrophage cells were lowest in the codY + group.

Conclusions

YycF negatively regulate the expression of codY. By interaction with codY, YycF could modulate S. aureus biofilm formation via both eDNA- dependent and PIA- dependent pathways, which can be a significant target for antibiofilm. CodY not only impedes the pathogenicity but also has a role on immunoregulation. Thus, the current evidence may provide a supplementary strategy for managing biofilm infections.
Incorrectly corrected? QT interval analysis in rats and mice
Authors: Mulla Wesam , Murninkas Michael , Levi Or , Etzion Yoram
Published: October 2022

QT interval, a surrogate measure for ventricular action potential duration (APD) in the surface ECG, is widely used to identify cardiac abnormalities and drug safety. In humans, cardiac APD and QT interval are prominently affected by heart rate (HR), leading to widely accepted formulas to correct the QT interval for HR changes (QT corrected - QTc). While QTc is widely used in the clinic, the proper way to correct the QT interval in small mammals such as rats and mice is not clear. Over the years, empiric correction formulas were developed for rats and mice, which are widely used in the literature. Recent experimental findings obtained from pharmacological and direct pacing experiments in unanesthetized rodents show that the rate-adaptation properties are markedly different from those in humans and the use of existing QTc formulae can lead to major errors in data interpretation. In the present review, these experimental findings are summarized and discussed.
Acute effects of combined isometric and plyometric conditioning activities on sports performance and tendon stiffness in female volleyball players
Authors: Kalinowski Rafał , Pisz Anna , Kolinger Dominik , Wilk Michał , Stastny Petr , Krzysztofik Michał
Published: October 2022

This study aimed to compare the effects of bilateral and unilateral conditioning activities (CA; combined isometric and plyometric) on countermovement jump performance, modified t-agility test, Achilles tendon stiffness and skin surface temperature. Thirteen female semi-professional volleyball players performed two CAs in random order: 1) bilateral isometric half back squats followed by bilateral drop jumps (BI-CA); and 2) unilateral isometric half back squats followed by unilateral drop jumps (UNI-CA). To assess the effects of CAs, countermovement jump, modified t-agility test, Achilles tendon stiffness and skin surface temperature measurements were performed 5 min before and 6 min after the CA. Both CAs significantly increased thigh skin surface temperature from pre- to post-CA (BI-CA, p < 0.001; effect size [ES] = 1.41 and UNI-CA, p = 0.001; ES = 1.39) but none of them influenced modified t-agility test time (interaction: p = 0.338, main effect of time: p = 0.121 and condition: p = 0.819). The countermovement jump height and modified reactive strength index significantly increased from pre-to post-CA during the BI-CA condition (p = 0.003, ES = 0.45, and p = 0.008, ES = 0.48) but not for UNI-CA (p = 0.061, ES = 0.18 and p = 0.065, ES = 0.26). No significant impact has been found for countermovement depth (interaction: p = 0.054, main effect of time: 0.097, and condition: p = 0.41) as well as for contraction time (interaction: p = 0.536, main effect of time: p = 0.224, and condition: p = 0.807). Moreover, stronger and weaker limb CMJ relative peak force significantly decreased from pre-to post-CA (p = 0.014, ES = −0.31, and p = 0.027, ES = −0.26; respectively) during UNI-CA condition but not for BI-CA (p = 0.096, ES = 0.23, and p = 1.41, ES = 0.18). The stronger and weaker limb Achilles tendon stiffness significantly increased from pre-to post-CA during the UNI-CA condition (p = 0.013, ES = 0.60 and p < 0.001, ES = 0.79; respectively) but not for BI-CA (p = 0.66; ES = 0.15 and p = 0.265; ES = 0.42). Furthermore, the post-CA stronger limb Achilles tendon stiffness during the UNI-CA was significantly higher than that noted during the BI-CA (p = 0.006, ES = 0.7). The present study showed that combined isometric and plyometric bilateral CA effectively improved the countermovement jump but did not enhance the t-agility test performance. These findings indicate that exercise combinations could effectively produce a post-activation performance enhancement effect but should replicate the following explosive task as much as possible.