bluuebunny/crossref_metadata_2025 huggingface dataset:
Herpes Zoster in a 2-Year-Old Child After a Single Dose of Varicella Vaccine
Authors: Barone Hope , Veremis Mary , Gildenberg Stuart
Published: March 2021

In this report, we describe a rare case of an immunocompetent 2-year-old child who developed herpes zoster (HZ) in the same dermatomal distribution as the vaccination site received several months prior. Although most cases of HZ caused by the vaccine-strain virus follow a mild disease course, affected patients are contagious to household members and may nevertheless develop severe complications such as herpes ophthalmicus and meningoencephalitis. Consideration of this entity and associated complications is critical for dermatologists when evaluating similar appearing eruptions.
Sweet Presentation of a Bitter Disease: Acute Febrile Neutrophilic Dermatosis Associated with Coccidioidomycoses
Authors: Jafri Zainab , Shedlofsky Lydia , Newman Andrew , Lam Travis , Mengesha Yebabe
Published: March 2021

Acute Febrile Neutrophilic Dermatosis, also known as Sweet Syndrome, is an uncommon inflammatory disorder. Though the exact etiology is unclear, it has been presented in association with various entities. The majority of cases present following upper respiratory infections or viral gastroenteritis. Other causes include drug-induced reactions, pregnancy-related manifestations, or in association with specific hematologic or solid tumors. Rarely, it has been associated with Coccidioidomycosis, a prevalent fungus endemic to the Southwestern regions of the United States with a literature review revealing only three previous cases of Coccidioidomycosis-associated Sweet Syndrome. Here we report two new cases in individuals residing in Arizona.
Pulmonary Manifestations in Pseudoxanthoma Elasticum: A Review of Current Literature
Authors: Yassky Noa , Wei Nancy , Lebwohl Mark
Published: March 2021

Background: Pseudoxanthoma Elasticum is a hereditary disease characterized by calcification of elastic fibers that result in cutaneous, ophthalmologic, and cardiovascular complications. As the pulmonary system contains multiple cell types with abundant elastic fibers, pulmonary manifestations are expected yet not often observed.
Objective: To review current literature reporting cases of pulmonary manifestations in patients with pseudoxanthoma elasticum.
Methods: A search of the PubMed computerized database limited to English language case reports and cross-sectional cohort studies as of December 2020 was performed using the key words “pseudoxanthoma elasticum”, “PXE”, “pulm*”, and “lung”.
Results: A total of 15 patients with clinical, radiologic, or histologic pulmonary manifestations of PXE were identified across four case reports and one cohort study. Patients who did present with pulmonary symptoms were exceedingly rare and reported only progressive exertional dyspnea.  
Discussion: Histologic and/or radiologic investigation of PXE patients who presented with progressive exertional dyspnea revealed calcification and irregularity of the elastic laminae in the pulmonary vasculature, the alveolar septa or both. Additionally, spirometry and diffusion studies in PXE patients revealed a restrictive pattern of lung disease with significantly decreased absolute total lung capacity compared to controls.
Conclusions: PXE patients with pulmonary symptoms severe enough to have clinical impact are exceedingly rare, and thus investigative workup is not often pursued. Further research is needed to elucidate the clinical impact of lung calcification in PXE patients.
Impact of coronavirus disease 2019 on assisted reproductive technique
Authors: Rozati Roya , Kumar Nancy , Minhaj Humaira , Bardia Avinash , Balaji A. B.
Published: March 2021

The coronavirus pandemic has had a great impact on many health sectors including pregnancy and infertility treatments such as in vitro fertilization, intrauterine insemination, ovulation induction, laparoscopy, hysteroscopy, and assisted reproductive techniques. Due to this situation in coronavirus disease 2019 (COVID-19) and relaxation permitted by government, allowing the non-essential services in a gradual manner, infertility services have been resumed as per the guidelines set by ministry of health and family welfare of India. The staff has to be triaged to meet the demands of this situation. Diagnostic evaluation using RT-PCR should be done at the commencement of treatment. If donor tests positive, cycle has to be called off. It is important to know, the effect of SARS-CoV2 on gametes, embryos, and early pregnancy. According to ESHRE, the probability of contamination of gametes and early stages of embryo by this virus is low. Certain new evidences are indicating possible transmission of this virus from mother to newborn, thus putting the pregnant women into high risk category. It is still not known if patients who continue to test positive for PCR remain infective throughout the period or their infectivity dissipates over time. Universal good practices must be followed in view of safety for both doctors and patients. COVID-19 has actually changed the way of infertility treatment is provided. Extensive guidelines and new protocols must be set up so as to have minimum risks.
Quantum and randomized lower bounds for local search on vertex-transitive graphs
Authors: Dinh H. , Russell A.
Published: March 2021

We study the problem of \emph{local search} on a graph. Given a real-valued black-box function $f$ on the graph's vertices, this is the problem of determining a local minimum of $f$---a vertex $v$ for which $f(v)$ is no more than $f$ evaluated at any of $v$'s neighbors. In 1983, Aldous gave the first strong lower bounds for the problem, showing that any randomized algorithm requires $\Omega(2^{n/2 - o(n)} )$ queries to determine a local minima on the $n$-dimensional hypercube. The next major step forward was not until 2004 when Aaronson, introducing a new method for query complexity bounds, both strengthened this lower bound to $\Omega(2^{n/2}/n^2)$ and gave an analogous lower bound on the quantum query complexity. While these bounds are very strong, they are known only for narrow families of graphs (hypercubes and grids). We show how to generalize Aaronson's techniques in order to give randomized (and quantum) lower bounds on the query complexity of local search for the family of vertex-transitive graphs. In particular, we show that for any vertex-transitive graph $G$ of $N$ vertices and diameter $d$, the randomized and quantum query complexities for local search on $G$ are $\Omega\left({\sqrt{N}}/{d\log N}\right)$ and $\Omega\left({\sqrt[4]{N}}/{\sqrt{d\log N}}\right)$, respectively.
Security of practical phase-coding quantum key distribution
Authors: Li Hong-Wei , Yin Zheng-Qiang , Han Zheng-Fu , Bao Wan-Su , Guo Guang-Can
Published: March 2021

Security proof of practical quantum key distribution (QKD) has attracted a lot of attentions in recent years. Most of real-life QKD implementations are based on phase-coding BB84 protocol, which usually use Unbalanced Mach-Zehnder Interferometer (UMZI) as the information encoder and decoder. However, the long arm and short arm of UMZI will introduce different loss in practical experimental realizations, the state emitted by Alice's side is nolonger perfect BB84 states correspondingly. In this paper, we will give the security analysis in this situation. Counterintuitively, active compensation for this different loss will only lower the secret key bit rate.
ONLINE EDUCATION - PROBLEMS AND SOLUTIONS
Authors:   PhD, University of Medicine and Pharmacy “Carol Davila”, Bucharest, ROMANIA, ANDREESCU Prof. Cristina Veronica
Published: March 2021

The online platforms have been in a continuous development since the beginning of their appearance, being classified according to the field of activity. This article discusses some features of the online educational platforms, that serve the distance learning adopted during this pandemic period by the majority of nations on the planet, to continue the educational progress, at all levels of learning. The article is intended exclusively for the platforms used at the pre-university level of education and illustrates theoretical notions about them, represented by typologies, characteristics, and the features that platforms have been applying. The online platforms, as any other software device, possess advantages and also limitations of the available functions, and this article illustrates their approach in the context of the formative type of assessments, as well as of the summative ones. The effects of using these platforms are highlighted by using the questionnaire survey. This has the final aim to identify the perceptions of the respondents on the use of the online educational platforms for conveying the school information and also to identify the psycho-social aspects that this approach entails. At the end of the article the results of students' attendance at the online courses are presented, results that were collected based on the monitoring study conducted on a sample of students.
TIKTOK - THE INFLUENCE ON SCHOOL PERFORMANCE AND SOCIAL LIFE OF ADOLESCENTS
Authors:   MSc, Faculty of Environmental Engineering and Food Science, ENACHE Prof. Adina NICHITA, Dumitru ,   ROMANIA
Published: March 2021

Mobile applications are a significant part of our lives, especially the applications that help solve particular problems at certain stages of our lives or those that are the very object of our work. In the field of education, mobile applications have been integrated in the teaching of lessons or in the transmission of information. Various applications on the market have been largely adopted for the information transmission from the educational environment. TikTok is one of these applications, and in this article we aim to analyze the advantages and disadvantages of using this application in the educational environment. At the same time, the effects of the heavy use of this application by adolescents are analyzed and also inadequate situations to be avoided in the use of the application are highlighted. Statistical data are presented through a questionnaire-based study. At the end of the article opinions on the purpose of the application and its use in education, as an educational tool are presented
EPSON (EARLY DETECTION FOR PARKINSON DISEASE) TINJAUAN PUSTAKA DISBIOSIS GUT MICROBIAL SEBAGAI POTENSI DETEKSI DINI PARKINSON MELALUI PEMERIKSAAN FESES
Authors: Novindra Qanita Adzkia , Alifah Fildzah Ghaisani , Syariafah Nadia Alfi
Published: March 2021

Parkinson disease (PD) merupakan salah satu penyakit neuro degeneratif yang tidak dapat disembuhkan dengan manifetasi klinis berupa gangguan pada gerak motorik. Saat ini diagnosis pada penyakit parkinson masih didasarkan pada gejala motorik yang timbul. Deteksi dini pada PD dibutuhkan sehingga pasien akan mendapat penanganan sejak dini untuk mencegah patogenesis kerusakan neuron di substansia nigra. Berdasarkan penelitian, diketahui bahwa gejala berupa disfungsi usus muncul 5-7 tahun sebelum terjadi gangguan motorik pada pasien PD. Timbulnya disfungsi usus ini memiliki keterkaitan dengan ketidak seimbangan komposisi mikrobiota usus (GM). Tujuan dari literatur review ini adalah melakukan studi literatur mengenai hubungan antara komposisi GM dengan patogenesis parkinson disease sebagai dasar deteksi dini parkinson disease. Metode yang digunakan dalam proses literature review ini adalah metode PRISMA, dimana dari 261 sumber awal yang sudah penulis dapatkan sesuai dengan keyword menggunakan metode Boolean, terdapat 229 sumber yang di eksklusi karena tidak memenuhi kriteria inklusi yang ditetapkan penulis. Dari hasil dan pembahasan didapatkan bahwa disbiosis bakteri pada gastrointestinal tract adalah proses yang mengawali patogenesis dari PD. Hal ini dibuktikan dengan adanya peningkatan dua kali lipat konsentrasi Indoxyl Sulfat urin (indikator disbiosis mikroba) pada pasien. Terdapat pola unik perubahan komposisi mikroba saluran pencernaan, yaitu perubahan β- diversity, peningkatan pertumbuhan koloni bakteri genus Akkermansia, Genus Lactobacillus, dan Famili Enterobacteriaceae;dan penurunan pertumbuhan Genus Faecalibacterium, dan Genus Provotella. Kesimpulan yang didapatkan adalah perubahan komposisi bakteri di saluran pencernaan merupakan salah satu pemicu yang mengawali patogenesis PD dan bahwa pola unik perubahan komposisi gut microbial memiliki potensi untuk dijadikan deteksi dini Parkinson Disease.
Crustal Thermal Structure and Exhumation Rates in the Southern Alps Near the Central Alpine Fault, New Zealand
Authors: Michailos K , Sutherland Rupert , Townend John , Savage Martha
Published: March 2021

© 2020. American Geophysical Union. All Rights Reserved. We investigate orogenic uplift rates and the thermal structure of the crust in the hanging wall of the Alpine Fault, New Zealand, using the hypocenters of 7,719 earthquakes that occurred in the central Southern Alps between late 2008 and early 2017, and previously published thermochronological data. We assume that the base of the seismogenic zone corresponds to a brittle-ductile transition at some fixed temperature, which we estimate by fitting the combined thermochronological data and distribution of seismicity using a multi-1-D approach. We find that exhumation rates vary from 1 to 8 mm/yr, with maximum values observed in the area of highest topography near Aoraki/Mount Cook, a finding consistent with previous geologic and geodetic analyses. We estimate the temperature of the brittle-ductile transition beneath the Southern Alps to be 410–430°C, which is higher than expected for Alpine Fault rocks whose bulk lithology is likely dominated by quartz. The high estimated temperatures at the base of the seismogenic zone likely reflect the unmodeled effects of high fluid pressures or strain rates.
Rancang bangun dan uji performansi mesin pencampur beberuk, makanan khas Lombok
Authors: Ansar A. , Muttalib S. , Sabani R. , Kustina R.
Published: March 2021

During this time the process of making beberuk was still done traditionally using a mortar as a mixer, so that production is very limited, while the market demand is quite high. To increase productivity, it is necessary to design a machine that can increase the production capacity of the beberuk. The research method begins with the mixing machine design process, then continues with the assembly process and engine performance test. The design of the mixing machine is done with two approaches namely functional approach and structural approach. Test engine performance on 3 power variations namely 144, 168, and 192 watts and 3-time variations namely 30, 45, and 60 seconds. The results showed that the cylindrical mixing chamber has a diameter of 20 cm and a height of 50 cm. The mixing tube has a rectangular hopper with dimensions of 37 cm long and 9 cm wide. Engine performance test results showed the best results on 168 watts of power treatment and 30 seconds with the results of mixing not bubbly and still looks tomato chunks and is not too smooth according to the standard beberuk food.
A Pharmacokinetic-Pharmacodynamic Study of Intravenous Midazolam and Flumazenil in Adult New Zealand White—Californian Rabbits (Oryctolagus cuniculus)
Authors: Rousseau-Blass Frédérik , Cribb Alastair E , Beaudry Francis , Pang Daniel SJ
Published: March 2021

Flumazenil, a competitive GABAA receptor antagonist, is commonly used in rabbits to shorten sedation or postanesthetic recovery after benzodiazepine administration. However, no combined pharmacokinetic (PK) and pharmacodynamic (PD) data are available to guide its administration
in this species. In a prospective, randomized, blinded, crossover study design, the efficacy of IV flumazenil (FLU; 0.05 mg/kg) or saline control (SAL; equal volume) to reverse the loss of righting reflex (LORR) induced by IV midazolam (1.2 mg/kg) was investigated in 15 New Zealand white rabbits
(2.73 to 4.65 kg, 1 y old). Rabbits were instrumented with arterial (central auricular artery) and venous (marginal auricular vein) catheters. After baseline blood sampling, IV midazolam was injected (T0). Flumazenil or saline (FLU/SAL) was injected 30 s after LORR. Arterial blood samples
were collected at 1 and 3 min after midazolam injection, and at 1, 3, 6, 10, 15, 21, 28, 36, 45 and 60 min after injection with flumazenil. Plasma samples for midazolam, 1-OH-midazolam and flumazenil were analyzed using high performance liquid chromatography-high-resolution mass spectrometry
and the time to return of righting reflex (ReRR) was compared between groups (Wilcoxon test). FLU terminal half-life, plasma clearance and volume of distribution were 26.3 min [95%CI: 23.3 to 29.3], 18.74 mL/min/kg [16.47 to 21.00] and 0.63 L/kg [0.55 to 0.71], respectively. ReRR was 25 times
faster in rabbits treated with FLU (23 [8 to 44] s) compared with SAL (576 [130 to 1141] s; 95%CI [425 to 914 s]). Return of sedation (lateral recumbency) occurred in both groups (7/13 in FLU; 12/13 in SAL) with return of LORR in a few animals (4/13 in FLU; 7/13 in SAL) at 1540 [858 to 2328]
s. In the population and anesthesia protocol studied, flumazenil quickly and reliably reversed sedation induced by midazolam injection. However, the potential return of sedation after flumazenil administration warrants careful monitoring in the recovery period.
MODEL OF INTERACTION BETWEEN ADVERTISING, PR AND JOURNALISM
Authors: Ivanova Iryna , Afanasieva Elena
Published: March 2021

The article is an overview of the journalism – PR – advertising relationship at the terminological, empirical-analytical and practical levels. It traces the state of the discussion of these correlations in the post-soviet media such as Ukraine. The study describes that domesticating the importance of the appropriate partnership between the three communication technologies. The thesis is that journalism, advertising and PR create a mutual connection that takes place in an atmosphere of PR and advertising permissiveness and deepens with the development of digitalization, Social network development. The present research is based on a comprehensive approach. The inductive and deductive methods are adopted to discuss theoretical materials, and the interdisciplinary research method is used to detect PR-specific features as a philosophy of a new journalism project. The interpretive approach, usually employed to analyze media text as a complex synthetic structure, was also taken into consideration. The analytical method application identified the modern means of substantiating the ideological, esthetical and informative value of brand journalism and spin doctor. The innovative character of modern media as a behavioral strategy in the advertising and PR industry consists in the fact that it is a form of creative production and behavior rather than adapting a specific communication situation. The article examines the main directions of contemporary interactions between PR, advertising and journalism as a media content creation. In this context, it is asserted that advertising, journalism and PR activities can contribute to the creation of media content. At some point, good media content is achieved not only as a result of this competition but also from the correlation between PR, advertising and journalism.
THE CONCEPT OF ENEMY: REPRESENTATION IN THE UKRAINIAN MILITARY DOCUMENTARIES
Authors: Chervinchuk Alina
Published: March 2021

Research methodology. The following methods were used in this research: general scientific methods (descriptive, analysis, synthesis, comparison) and special (structural, hermeneutic, narrative, method of content analysis). We identified words related to the concept of the enemy and determined the context in which they are used by the authors of the collections Results. The formats of reflection of military reality in collections of military documentaries are investigated. It is emphasized that the authors-observers of events as professional communicators form a vision of events based on categories understandable to the audience – «own» and «others». Instead, the authors-participants go events have more creative space and pay more attention to their own emotional state and reflections. It is defined how the enemy is depicted and what place he occupies in the military reality represented by the authors. It is emphasized that the authors reflect the enemy in different ways. In particular, the authors-observers of the events tried to form a comprehensive vision of the events, and therefore paid much attention to the opposite side of the military conflict. Authors-participants of the events tend to show the enemy as a mass to be opposed. In such collections, the enemy is specified only in the presence of evidence confirming the presence of Russians or militants. Novelty. The research for the first time investigates the methods of representation of mi­litary activity in the collections of Ukrainian military documentaries. The article is devoted to the analysis of how the authors represent the enemy. Practical importance. The analysis of collections of military documentaries will allow to study the phenomenon of war and to trace the peculiarities of the authors’ representation of military reality.
CALCULATING AND MODELING ROPE MECHANISM OF A MOBILE CRANE TELESCOPIC BOOM
Authors: Reutov Aleksandr
Published: March 2021

Power analysis and computer modeling of moving the telescopic boom rope mechanism using the “Universal Mechanism” software package, considering the mechanical characteristics of the ropes, boom sections and their contact interaction, have been carried out. The dependences for calculating the preliminary tension of the ropes are obtained, the regularities of operating the cable mechanism of the crane telescopic boom are established.
Re: Skeletides: A Modular, Simplified Physical Model of Protein Secondary Structure
Authors: Chakraborty Promita
Published: March 2021

This is a rebuttal of a paper titled "Skeletides: A Modular, Simplified Physical Model of Protein Secondary Structure", published in January 2020 (Ahead of Print) and April 2020 (in-print) in the journal 3D Printing and Additive Manufacturing . A formal complaint made provided no results. Despite my complaint to the Editor-In-Chief of the journal, Skylar Tibbits, in January, this paper went ahead and got published in print in April 2020 without proper citation, mention or acknowledgement of my work. Here I enlist the similarities between my work and this paper. Parts of this rebuttal have been reproduced from my prior blogposts about the problem explaining the details of the circumstances. In order to keep this paper in print, a proper attribution of my work is necessary, and an ethical thing to do (a list of citations is provided).
Ritual Mistis di Dunia Politik : Studi paa Ritual Ngalab Berkah di Gunung Kemukus
Authors: Zanuar Afrizal
Published: March 2021

Ritual Mistis di Dunia Politik
GEREJA DAN KEMISKINAN: DISKURSUS PERAN GEREJA DI TENGAH KEMISKINAN
Authors: Priyadi Jonathan Mario Dwi
Published: March 2021

Peranan Gereja di tengah KemiskinanGereja tidak bisa melepaskan diri dari persoalan kemiskinan yang sedangdihadapi. Justru panggilan gereja adalah terlibat secara aktif dalam memerangikemiskinan dan ketidakadilan. Orang miskin ada karena ketidakadilan yang harusmereka terima akibat kejahatan penguasa atau orang-orang yang memiliki kuasa, danyang merampas hak-hak yang seharusnya dimiliki. Inilah pemiskinan.
Đừng bác bỏ sự giàu có của mình
Authors: Vuong Quan-Hoang
Published: March 2021

Có vẻ như người ta lẩn tránh sự giàu có, không, ý tôi là "cái tiếng" là người giàu có. Điều này rất mâu thuẫn với khát vọng làm giàu thể hiện rõ nét ở doanh nhân, cũng như chuyện kêu gọi nhà đầu tư, tối đa hóa lợi nhuận đang trở thành mục tiêu không chỉ riêng của giới nghiệp chủ.
672020312_PENDAMPINGAN PASTORAL HOLISTIK: SEBUAH USULAN KONSEPTUAL PEMBINAAN WARGA GEREJA
Authors: Ginting William Sayna Toto
Published: March 2021

Pendampingan Pastoral Holistik:Sebuah Usulan Konseptual Pembinaan Warga Gereja. Gereja yang kuat terbentuk dari jemaat yang kuat. Jemaat yang kuat didapat dari pendampingan pastoral yang secara aktif menyentuh keseluruhan kehidupan warga gerejanya. Gereja perlu berusaha mengembangkan pendampingan pastoral holistik kepada jemaatnya. Berbagai program yang dirancang digunakan untuk mencapai sebuah pendampingan pastoral holistik. Jemaat yang multikultur disertai dengan multiproblem, mengharuskan para pelaku pastoral mengatur strategi dan menyusun model untuk dapat memberikan pelayanan pendampingan pastoral holistik kepada warga gerejanya. Konsep pendampingan pastoral holistik dari Howard Clinebell dan Totok Wiryasaputra akan membantu menganalisis dalam kerangka membuat pembinaan warga gereja secara holistik. Kerangka teoretis tersebut akan dipadukan dengan model pastoral yang dikembangkan oleh David Yonggi Cho di Yoido Full Gospel Church. Konsep dan model pendampingan pastoral holistik saling menopang serta menjadi “pisau bedah” dari pendampingan pastoral yang bermuara kepada efektifitas pemberdayaan kaum awam dan metode kelompok kecil.
GEOGEBRA APPLICATION AS THE DEVELOPMENT OF LINEAR PROGRAM TEACHING MATERIALS IN SMA KABUPATEN BURU
Authors: HARZIKO
Published: March 2021

ABSTRACTThis research is motivated by the fact that the ability of mathematical communication in Indonesia is low. The models and approaches used in the learning process are one of the supporting factors for learning mathematics in the classroom. This study aimed to analyze SMA 1 Namlea students' mathematical communication skills with realistic mathematics learning assisted by GeoGebra. The research method used is quasi-experimental. WHO researched SMA Negeri 1 Namlea, Buru Regency. The analysis results show that the test instrument is valid and reliable to be used for pretest and posttest. The results showed that the mathematical communication of students who received realistic mathematics learning assisted by GeoGebra was better than students who received realistic mathematics learning without GeoGebra. The results also showed that there was a positive response from students towards learning realistic mathematics with GeoGebra.KEYWORDS: Realistic Mathematics, GeoGebra & Mathematical Communication
sosiologi anak
Authors: Foenale Yusri Viana
Published: March 2021

Sosiologi Anak karya Prof. Dr. Bagong sulyanto, menyajikan tentang potret buram dan berbagai permasalahan yang dihadapi anak-anak rawan di Tanah air, serta mengajak para pendidik, mahasiswa, dan pemerhati anak untuk bersama-sama memecahkan atau menangani masalah yang terjadi pada anak. Media masa memberikan informasi kepada kita bahwa hampir semua daerah di Indonesia banyak kasus tentang anak-anak. Baik itu korban kekerasan seksual, anak-anak yang teraniaya, anak yang tereksploitasi akibat pekerjaan yang menumpuk dan diluar kemampuannya sebagai anak-anak, maupun kisah-kisah lain yang memperlihatkan kepada setiap kita tentang kasus terhadap anak-anak.
Reopening schools without strict COVID-19 mitigation measures risks accelerating the pandemic
Authors: Gurdasani Deepti , Alwan Nisreen , Greenhalgh Trisha , Hyde Zoë , Johnson Luke , Roderick Paul , Michie Susan , Mckee Martin , Prather Kimberly A. , Rasmussen Sarah , Reicher Stephen , Ziauddeen Hisham
Published: March 2021

On 22nd February, the UK government announced schools in England would fully reopen on the 8th March 2021. While returning to school as soon as possible is imperative for the education, social development, and mental and physical welfare of children, not enough has been done to make schools safer for students and staff. Multi-layered mitigations can substantially reduce the risk of transmission within schools and into households. In the Appendix we outline a set of recommendations, in line with CDC guidelines and practiced in many countries, to reduce the risk of transmission in schools and mitigate the impact of COVID-19 on children and families. Making schools safer goes hand in hand with reducing community transmission, and is essential to allow schools to safely reopen and remain open.
Gereja Dan Kemiskinan: Diskursus Peran Gereja Di Tengah Kemiskinan
Authors: Salhuteru Brayen Eliza
Published: March 2021

Gereja dan Kemiskinan: Diskursus Peran Gereja di Tengah Kemiskinan.Permasalahan kemiskinan bukan hanya menjadi masalah lokal, namun menjadi masalah yang digumulkanoleh dunia. Gereja sebagai mandataris Tuhan di tengah dunia, dituntut untuk dapat berperan dalammembantu masalah kemiskinan. Bagaimanakah sewajarnya gereja berperan di tengah kemiskinanmasyarakat? Dengan menggunakan metode deskriptif analisis, serta meminjam pemikiran Karl Marx,untuk menelisik peran gereja dalam membantu mengatasi permasalahan kemiskinan. Panggilan gerejayang seharusnya adalah untuk menyuarakan ketidakadilan dan penindasan hak-hak orang miskin. Gerejahadir untuk berpihak kepada yang lemah, tidak berdaya, miskin, dan yang terpinggirkan. Jika gereja tidakmemiliki keperpihakan kepada yang lemah, maka kehadiran gereja tidak memiliki makna. Gereja perluterus menerus menyuarakan kritik profetisnya tanpa pandang bulu terhadap berbagai penyalahgunaankekuasaan, terjadinya ketidakadilan, terampasnya hak-hak masyarakat, dan terhadap sistim yangmenindas serta memiskinkan manusia. Spiritualitas dan religiusitas jemaat juga harus sampai kepadasebuah kesalehan sosial, di mana energi spiritual yang dimiliki jemaat mampu untuk mendorongkepeduliannya akan berbagai persoalan kehidupan masyarakat. Spiritualitas seperti inilah yang harusmenjadi perhatian gereja dalam membangun kehidupan jemaat. Salib harus dipahami sebagai refleksi ataspenderitaan dan kematian Kristus, namun di saat yang sama pula harus mampu membuka mata dantelinga akan penderitaan, kesengsaraan, dan pengharapan manusia akan harkat dan martabatnya sebagaimanusia. Disitulah gereja berperan.
The mediating role of attachment and mentalising in the relationship between childhood trauma, self-harm and suicidality
Authors: Stagaki Maria , Nolte Tobias , Feigenbaum Janet , King-Casas Brooks , Lohrenz Terry , Fonagy Peter , Montague P. Read
Published: March 2021

Although the relationship between childhood trauma, self-harm and suicidality is well-established, less is known about the mediating mechanisms explaining it. Based on a developmental mentalisation-based theoretical framework, childhood adversity compromises mentalising ability and attachment security, which in turn increase vulnerability to later stressors in adulthood. This study aimed, thus, to investigate the role of attachment and mentalising as potential mechanisms in this relationship. In a cross-sectional design, 907 adults from clinical and community settings completed self-report questionnaires on retrospectively rated childhood trauma, and current attachment to the romantic partner, mentalising, self-harm, suicidal ideation and attempt. Structural equation modelling was used to examine the data and childhood trauma was conceptualised as a general factor in a confirmatory bifactor model. The results showed that childhood trauma was both directly associated with self-harm and suicidality and indirectly via the pathways of attachment and mentalising. These findings indicate that insecure attachment and impaired mentalising partially explain the association between childhood trauma, self-harm and suicidality. Clinically, they provide support for the potential of mentalisation-based therapy or other psychosocial interventions that aim to mitigate the risk of self-harm and suicidality among individuals who have experienced childhood maltreatment via increasing understanding of self and other mental states.
Linguistic-Based Detection of Fake News in Social Media
Authors: Mahyoob Mohammad , Algaraady Jeehaan , Alrahaili Musaad
Published: March 2021

The tremendous growth and impact of fake news as a hot research field gained the public’s attention and threatened their safety in recent years. However, there is a wide range of developed fashions to detect fake contents, either those human-based approaches or machine-based approaches; both have shown inadequacy and limitations, especially those fully automatic approaches. The purpose of this analytic study of media news language is to investigate and identify the linguistic features and their contribution in analyzing data to detect, filter, and differentiate between fake and authentic news texts. This study outlines promising uses of linguistic indicators and adds a rather unconventional outlook to prior literature. It utilizes qualitative and quantitative data analysis as an analytic method to identify systematic nuances between fake and factual news in terms of detecting and comparing 16 attributes under three main linguistic features categories (lexical, grammatical, and syntactic features) assigned manually to news texts. The obtained datasets consist of publicly available right documents on the Politi-fact website and the raw (test) data set collected randomly from news posts on Facebook pages. The results show that linguistic features, especially grammatical features, help determine untrustworthy texts and demonstrate that most of the test news tends to be unreliable articles.
Traditional Medicaments Combating Against Fibromyalgia- A Review
Authors: Bhardwaj Vanshika , Gupta Neha , Anju Dr. , Arora Khusboo , Jha Avishek Kumar , Kumar Abhishek , Bansal Priya
Published: March 2021

Fibromyalgia syndrome is a persistent condition characterized by frequent body pain at different tender points, sleep disturbance, fatigue, anxiety, impaired condition, joint stiffness. 5% of the world population mainly middle and old aged people suffer from it. Women are more prone towards this disease. The underlying pathophysiology of this syndrome is still unknown. Common symptoms of this syndrome mainly include chronic pain, fatigue, sleep disturbance, depression, joints stiffness, central sensitization, allodynia & hyperalgesia. There is no confirmatory blood test or imaging for diagnosis of fibromyalgia. The diagnosis criteria were set by The American College of Rheumatology (ACR) in 1990 and then modified further in 2010. The main drugs used for treatment mainly include Selective Serotonin Reuptake Inhibitor (SSRI) antidepressants, anticonvulsants, analgesics, Nonsteroidal anti-inflammatory drug, nerve pain medications and muscle relaxants. Therapies are also used for pain relieve such as acupuncture, graded exercise, stretching, massage, chiropractic treatment techniques, cognitive behavioural therapy, hydrotherapy, biofeedback and group support to overcome depression but they have low efficacy. Selfcare is another major factor for treatment like stress management, healthy diet, relaxation techniques and physical exercise. Due to various side effects of drugs, nowadays scientist and researchers having an eye on medicinal plants and their secondary constituents for treatment of fibromyalgia. In this review, authors tried to compile various medicinal plants and their secondary metabolites having potential to treat fibromyalgia.
Synthesis, Isolation and Biological Evaluation of a New Active Quinone Methide Derived Curcuminoid
Authors: Sinai Tomer , Singh Brijesh , Sintov Amnon C , Ben-Shabat Shimon
Published: March 2021

A new curcuminoid, quinone methide cyclopentadione (QMC), was synthesized by oxidation of curcumin (CUR) in the presence of potassium ferricyanide, and further isolated and analyzed. QMC was found to be a relatively water-soluble curcuminoid, and more stable than CUR in citric-phosphate buffer solutions. Unlike CUR, QMC possesses a pH-independent stability. In plasma, QMC was degraded by 50% after 8 hours and reached 30% of its initial concentration after 48h, while CUR was thoroughly decomposed. It has been demonstrated that QMC has a similar anti-proliferative activity as CUR in three different cancer cell lines- MCF-7, PC3 and HT29. Molecular examination of QMC in cancer cells exhibited similar effect to CUR on two transcription factors, Nrf-2 and NF-κB. An anti-inflammatory activity of QMC was demonstrated by measuring MCP-1 secretion levels in TNFα-induced human keratinocytes cell culture, which had been pre-treated with either CUR or QMC. This report presents the advantages of the new quinone methide derived curcuminoid and its pharmaceutical potential as an alternative to the poorly soluble curcumin.
Ethnopharmacological uses, biological activities, chemistry and toxicological aspects of Ocimum americanum var. americanum (Lamiaceae)
Authors: Ali Hashim Mohamed , Nguta Joseph Mwanzia , Mapenay Isaac Ole , Musila Fredrick Mutie , Omambia Vincent Mokoro , Matara Dorine Nyak
Published: March 2021

The rationale for the use of Ocimum americanum var. americanum in herbal medicine is largely based on the longstanding experience of traditional medicine practitioners. The genus Ocimum is extensively used in Eastern Africa in folkloric practice against a wide range of illnesses. The present paper intends to bring a comprehensive overview of O. americanum var. americanum in regard to its biological activities, ethnopharmacological uses, phytochemical and toxicological effects. The literature search was conducted using Google, Google Scholar, Chemical abstracts, Sciverse; JSTOR, Medline, PubMed, Science Direct, Scopus and Springer Link. O. americanum var. americanum extracts have been shown to have antimicrobial, antioxidant, antiproliferative, insecticidal, and repellent activities. Literature on the activity of O. americanum var. americanum extracts against metabolic syndromes such as diabetes, hyperlipidaemias and hypertension is scanty. Toxicological data is also limited; however, the accessible information indicates non-toxicity of O. americanum var. americanum extracts. Substantial variations in phytochemical constituents of this particular species are observed, which may be attributed to edaphic differences as well as ecoclimatic regions.
Evaluation on Triaging Pathway Strategy Guidelines for Cases with Elipidae Bite during COVID-19 Pandemic at Emergency Department
Authors: Khusairi Zainul Ikhwan Ahmad
Published: March 2021

Introduction: Emergency departments (ED) typically practice a triage system to classify patients into priority levels. A triage system is commonly used in crowded emergency rooms to determine which patient should be seen and treated immediately.Objective: The objective of this study was to evaluate the effectiveness of triaging pathway guidelines for critical cases seen in the Emergency Department during the COVID-19 outbreak.Case Presentation: Emergency Department, Taiping Hospital is practicing a triaging system which consists of two divisions; cases with respiratory symptoms (SARI) and cases without symptoms of respiratory impairment (non-SARI). A patient with snake bite was presented at the Emergency Department, Taiping Hospital with symptoms of numbness at the site of the bite and a complaint of difficulty to open the eyes, while tachycardia was noted. However, no shortness of breath or difficulty in breathing was reported. COVID-19 rapid screening was done and the patient was treated under Red Zone (non-SARI). Luckily, the patient survived and was stable with no reaction observed after treated with Neuro Polyvalent Antivenom 50ml in 500ml normal saline over one hour.Conclusion: The available patient triaging pathway strategy guideline was effectively practiced by paramedics when managing critical cases at the Emergency Department during COVID-19 outbreak. Other emergency departments are advised to practice effective and appropriate triaging pathway strategy guidelines to save patients’ lives.International Journal of Human and Health Sciences Supplementary Issue: 2021 Page: S15
Barriers to Physical Activity Among Pregnant Women During Pregnancy
Authors: Aslam Fatima , Aziz Karimah Hanim Abd , Jamani Nurjasmine Aida , Rus Razman Mohd
Published: March 2021

Introduction: Co-morbidities such as obesity, gestational diabetes and pregnancy induced hypertension during pregnancy can be dangerous to the mother and foetus. Regular physical activity during pregnancy not only maintains maternal and foetal wellbeing, but it also maintains physical fitness and brings various health benefits. However, many women reduce their physical activity levels during pregnancy.Objectives: Thus, this study aimed to identify the barriers that could prevent pregnant mothers from doing physical activities.Methods: This is a cross-sectional study involving 168 pregnant women aged 18 to 35 years between gestational age 12 to 35 weeks in a primary health clinic in Kuantan, Pahang. Their socio-demographic characteristics were recorded, and barriers for physical activity assessed through a set of pre-tested questionnaire.Descriptive statisticswere used to describe the sociodemographiccharacteristics and the barriers.Results: The mean (SD) age was 28.0 (3.6) and majority of them were of Malay ethnicity from B40 group. Two thirds (74.4%) had tertiary education and 66.7% were working mothers. More than half (53.0%) of the participants wereoverweight and obese.Moreover, 58% of the participants had leg cramp and 63.1% felt fatigue. Almost 80.4% had backache and 46.4% had epigastric discomfort.Conclusion: Barriers such as leg cramp, backache, fatigue and epigastric discomfort could prevent pregnant women from conducting physical activities. Opportunistic recommendation by physician and concerns on the physical activity should be addressed.International Journal of Human and Health Sciences Supplementary Issue: 2021 Page: S23
2001 FİNANSAL KRİZİ, KURUMSAL YÖNETİM VE VEKALET MALİYETİ: İSO 500 FİRMALARINDAN BULGULAR
Authors: DORUK Ömer Tuğsal
Published: March 2021

Vekalet maliyeti, finans literatüründe oldukça önemli bir yer tutan bir davranışsal kurumsal finans sorunu olma özelliğindedir. Vekalet maliyeti uluslararası literatürde sıkça tartışılmasına rağmen Türkiye eksenli literatür göreli olarak oldukça sınırlıdır. Bu çalışmada 2001 finansal krizi öncesi, kriz esnasında ve kriz dönemlerinde vekalet maliyeti yabancı ortakları olan firmalar ile diğerleri arasında yatay kesit regresyon analizleri ve bu analizlere dayalı marjinal etkiler vasıtasıyla test edilmektedir. Elde edilen bulgular vekalet maliyeti açısından 2001 finansal krizi döneminde, kriz öncesi ve sonrasında iki firma grubu arasında önemli bir farklılaşma olduğunu göstermektedir. Elde edilen bulgular farklı sağlamlık kontrollerinde bir değişiklik göstermemektedir.
There’s an App for That: Vaginal Hysterectomy
Authors: Miyazaki Douglas
Published: March 2021

Objective: To create an instructional app which includes medical knowledge, procedural steps and assessments based on the American Congress of Obstetrician and Gynecologists (ACOG) curriculum for vaginal hysterectomy. Methods: A survey of recent medical education literature and the use of app technology found that millennial trainees prefer engaging technology-enhanced learning opportunities. The vaginal hysterectomy procedure currently has a variety of resident evaluations and case tracking methods. Results: Key features of the application include: 1) ACOG curriculum for vaginal hysterectomy, 2) a complete step by step live and simulated surgical video tutorial, 3) a procedural step by step assessment (10 steps-- 0-10 score), 4) a global surgical rating scale (7 metrics), and 5) a knowledge based assessment (4 metrics, 0-4 scale). The data captured on the app can be accessed via IPAD and iPhone mobile devices and is verified by Apple. The evaluations can be directly emailed to any database. Conclusion: A comprehensive instructional surgery app coupled with real time assessment will provide greater learning efficiency and will more effectively improve surgical skills. This app has the potential to standardize surgical evaluation in the operating room and provide a more efficient method to track surgeon competency using ACOG guidelines. The assessment is currently employed by the ACOG Simulation Consortium Working group during vaginal hysterectomy simulation and is part of a surgical simulation course certified by the ABOG for MOC credits.
Teen Pregnancy and Situation of the Clinics Hospital of Montevideo Uruguay: Observational Study
Authors: Feldman Florencia
Published: March 2021

Introduction: Adolescence constitutes one of the most important transition stages in life and is characterized by changes representing a stage of vulnerability. Teen pregnancy is one of the most important medical dilemmas, Uruguay considered reducing it in the framework of the "2020 National Health Objectives". Objective: to describe the percentage of births, repetition of pregnancy and Voluntary Interruption of Pregnancy (IVE) in the adolescent population using the Montevideo-Uruguay Clinic Hospital between 2009-2017. Material and methods: observational, descriptive, retrospective study. Results: 1,574 births were in adolescents (24.02%). 29.8% occurred in users with previous pregnancies and 19.1% had at least one child alive. 19.18% of the IVE were in adolescents. Discussion and conclusions: There is a stagnation of the percentages of the parameters analyzed in these years. Teen pregnancy and its repetition constitute a failure of health policies in sexual education and it is necessary to increase our efforts to reduce them.
Case Report of Nuchal Cord Associated Stillbirth: What to Learn From the Complaints to the Diagnosis?
Authors: PA Philippe
Published: March 2021

Nuchal cord is the umbilical cord accident least associated with stillbirths. It is a common occurrence; however, the expertise to diagnose multiple and tight loops on ultrasound is minimal, especially in limited-resource settings. We report a 30 year-old gravida 1, who presented at a gestation of 39/40+6/7 with a 2 day history of inability to appreciate foetal movements. An urgent obstetric ultrasound revealed absent foetal cardiac activity, reduced amniotic fluid and normal placenta but the report had no comments on the umbilical cord. She delivered a macerated male infant with a tight cord around the neck thrice. This case report highlights the importance of third trimester sonography screening of umbilical cord abnormalities and the mechanism of intrauterine foetal death associated with umbilical cord accidents.
Suboptimal Bowel Function after (Recto) Sigmoid Resection in Patients with Deep Infiltrating Endometriosis
Authors: Al-Saidi Aia
Published: March 2021

Purpose: To investigate the postoperative outcomes regarding bowel functions in women and the pattern of symptoms after surgical treatment for deep infiltrating endometriosis in comparison with healthy subjects. Methods: This cross-sectional study was designed as a single tertiary-level academic center. We included 130 female adult patients who had undergone (recto) sigmoid resection for deep infiltrating endometriosis between January 2005 and December 2015. Patients were randomly age-matched to two controls derived from the general population in the Netherlands. We measured the prevalence of constipation, fecal incontinence, Irritable Bowel Syndrome and the Low Anterior Resection Syndrome Score. Results: The prevalence of constipation, fecal incontinence, and irritable bowel syndrome in the patients was significantly higher than in the controls (50.8% versus 26.2% and 15.4% versus 5.4%, and 14.6% versus 5.4%, respectively, P < 0.05 for each). The prevalence of constipation and fecal incontinence was lower in the patients who had undergone surgery longer than 24 months ago, in comparison with those who had undergone surgery less than 24 months ago (46.7% versus 69.9% and 15.0% versus 17.4%), which was still significantly higher in comparison to the control group. The low anterior resection syndrome score was significantly higher in the patients than in the controls. Conclusion: The postoperative outcomes in patients treated for deep infiltrated endometriosis regarding constipation, fecal incontinence, and irritable bowel syndrome are suboptimal and do not come close to outcomes in the general female population in the Netherlands. These patients should be screened postoperatively and if necessary, treated for bowel functions.