bluuebunny/crossref_metadata_2025 huggingface dataset:
Failure of Percutaneous Catheter Drainage of Pancreatic Pseudocyst
Authors: Adams David B. , Srinivasan Ajai
Published: November 2022

Percutaneous catheter drainage (PCD) of symptomatic pancreatic pseudocysts under CT radiologic guidance is a valuable adjunct or alternative to operative pseudocyst management. PCD failure is characterized by the development of recurrent pseudocysts or external pancreatic fistulas. The purpose of this study is to define the cause and management of PCD failure patients. A retrospective review and analysis of patients with symptomatic pancreatic pseudocysts managed with PCD who required subsequent operative treatment because of PCD failure was undertaken. There were 23 study patients (18 men, 5 women) with a mean age of 44 years identified over a 13-year time period. Pancreatitis etiology was alcohol abuse in 10, gallstones in 7, pancreas divisum in 3, trauma in 2, and sphincter of Oddi dysfunction in 1. Endoscopic retrograde cholangiopancreatography findings were: 13 genu strictures, 4 main pancreatic duct dilations, 2 head strictures, 1 body stricture, 1 stricture in the tail, 1 intact duct, and 1 unknown. Operations used to manage PCD failures were: lateral pancreaticojejunostomy (LPJ) in 9 patients, Roux-en-Y pancreatic fistula jejunostomy in 7, distal pancreatectomy in 3, caudal pancreatectomy in 2, pancreatoduodenectomy in 1, cyst gastrotomy in 1, and caudal pancreatojejunostomy in 1. Follow-up has ranged from 1 to 13 years (mean, 5 years). Five patients who underwent pancreatic fistula jejunostomy developed recurrent pseudocysts or pancreatitis. There have been no recurrent pseudocysts or fistulas in patients managed with LPJ or pancreatic resection. Genu strictures were the cause of PCD failure in the majority of patients. LPJ is the treatment of choice for genu strictures but may not always be possible because of chronic inflammatory changes. Roux-en-Y pancreatic fistula jejunostomy is an acceptable alternative. Recurrent pseudocysts in the head and body are treated with LPJ with cyst incorporation. Pancreatic resection is appropriate for certain strictures of the head, body, and pancreatic tail. Failure of PCD is associated with an underlying ductal disorder that needs to be defined preoperatively with endoscopic retrograde cholangiopancreatography to select the appropriate operation.
Deep Venous Thrombosis in the Pediatric Trauma Population: An Unusual Event: Report of Three Cases
Authors: Grandas Oscar H. , Klar Melinda , Goldman Mitchell H. , Filston Howard C.
Published: November 2022

The incidence of deep venous thrombosis (DVT) in the pediatric population has been reported to be lower than in adults. Pediatric trauma patients have predisposing risk factors for DVT similar to those in the general trauma population. We reviewed the records of 2746 children under 16 years of age admitted to our Level I pediatric trauma service from 1989 to 1997. Only three cases of DVT were documented, all adolescents. DVT was located in the upper (n = 1) and lower (n = 1) extremity venous system. One patient presented with pulmonary embolism alone without identifiable DVT. Risk factors found were venous system manipulations, including atriocaval shunt, subclavian central line, and hyperinflated medical antishock trousers garment. Therapy consisted of heparin followed by warfarin anticoagulation. A vena cava filter was inserted in one patient for whom systemic anticoagulation was contraindicated. No DVT was seen in 1123 closed head injury patients or 29 spinal cord injury patients without associated risk factors. The thrombotic risk in pediatric trauma patients is low. Routine screening or prophylaxis is not indicated except for patients who are likely to remain immobile for an extended period of time and require prolonged rehabilitation, have venous manipulations, or present with clinical symptoms. Hematologic evaluation in patients with diagnosed DVT is necessary to identify individual risk factors.
Sentinel Lymph Node Dissection for Primary Cutaneous Melanoma: A Community Hospital's Initial Experience
Authors: Habib Fahim A. , Lodish Michael E. , Mittal Vijay K. , Young Shun C.
Published: November 2022

Management of the regional lymph nodes remains the most controversial aspect of treating patients with intermediate-thickness cutaneous melanoma. Prospective studies have failed to demonstrate a significant survival advantage for patients undergoing elective lymph node dissection. The sentinel lymph node dissection (SLND) technique has been proposed as a method of accurately identifying patients with occult metastases in whom a regional lymph node dissection would be indicated. The majority of studies evaluating this technique have come from academic centers, most with dedicated melanoma clinics. This report describes the initial experience with SLND at a community hospital. Fifteen patients with intermediate-thickness primary cutaneous melanoma underwent preoperative lymphoscintigraphy with 99Tc-sulfur colloid. In addition, intraoperative lymphatic mapping using intradermally injected isosulfan blue was performed. Dissection was guided by radioactivity levels (in counts per second) as measured by a hand-held gamma probe. The resected lymph node or nodes were evaluated for micrometastases using routine hematoxylin and eosin staining and immunohistochemistry with S-100 and HMB-45. All patients were followed clinically for any evidence of recurrence. A sentinel node(s) was identified on preoperative lymphoscintigraphy in all 15 patients (100%). A single sentinel node was identified in 11 of 15 (73%), two nodes in 3 (20%), and one node in 1 (6.7%). The hand-held gamma probe reading correlated well with the site marked the “hot spot” (600–15,320 cps for the hot spot versus 10–350 cps for background). The sentinel lymph node was successfully identified and resected in all 15 patients. Blue-stained lymphatics and/or lymph nodes were present in 8 of 15 (53%) cases. Histopathology was negative for evidence of occult micrometastases in all patients. At mean follow-up of 221 days, all 15 patients remain with no evidence of disease. The outcomes for mapping and harvesting the sentinel node at a community institution compare favorably with results at major academic institutions. SLND may therefore be offered to patients with intermediate-thickness cutaneous melanoma in the community hospital setting with regional lymph node dissection and adjuvant interferon α-2b as options for patients with nodal micrometastases.
Evaluating the Role of Physical and Radiographic Examinations in Assessing Bullet Tract Termination for Gunshot Victims
Authors: Kennedy Frank , Sullivan Jim , Arellano Debra , Roulier Rachelle
Published: November 2022

Knowledge of the path of a bullet and how it terminates is critical for expeditious assessment and optimal management of patients with gunshot wounds. To assess the accuracy of physical examination and X-rays in these patients, a prospective study was undertaken for all gunshot victims seen for a 1-year period on a single trauma service. The paramedics and trauma surgeons' physical examinations were evaluated for whether a bullet tract could be accurately categorized as 1) through and through, 2) graze, 3) palpable under dermis, or 4) retained (ie, not palpable). The impact of X-rays was assessed with regard to how it affected the trauma surgeons' categorization. A total of 78 patients were seen with a total of 120 bullet tracts. Seventy-seven per cent were injured by assault, and 64 per cent were shot with a 9-mm or .38-caliber handgun. Twenty of 60 (33%) bullet tracts on the torso terminated with a missile that was palpable under dermis, but only 2 of 10 neck (20%), 1 of 28 extremity (4%), and 1 of 22 head/face (5%) did so. Paramedics evaluated 15 torso bullet tracts that ended palpable under dermis, of which they detected 5 (33%). Upon initial examination, the trauma surgeon detected 11 of 20 torso bullet tracts that ended palpable under dermis (55%), and detected 14 of the 20 after X-rays were done (70%). Overall, obtaining X-rays changed the categorization for 15 of 111 bullet tracts (13%). We conclude that bullet tracts on the torso result in a subcutaneously palpable bullet one-third of the time, much more frequently than in other body regions. Paramedics only detect one-third of subcutaneously palpable missiles on the torso. X-rays change the categorization of bullet tracts infrequently. We recommend that a careful examination of the skin of the torso to detect palpable missiles be incorporated into the secondary survey of patients with wounds to that body region.
Detection of Surgical Glove Integrity
Authors: Sohn Richard L. , Murray Mary T. , Franko Alex , Hwang Paul K. , Dulchavsky Scott A. , Grimm Michele J.
Published: November 2022

Surgical glove integrity is essential for universal precautions; glove safety is verified by the water load test (WLT). Concerns regarding glove injury have prompted newer testing methodologies, including electrical conductance testing (ECT); however, the sensitivities of these tests are not known. We compared the sensitivity of WLT and ECT in detecting glove needle-stick injury in two commonly used brands of surgical gloves. Punctures were made with hollow-bore and solid surgical needles of various configurations. The WLT failed to detect glove holes from the smallest-caliber needles and only detected the injury in 60 per cent for the largest caliber. The ECT provided a graded index of glove injury in all holes made by both solid surgical needles and hollow-bore needles. The WLT is a poor test for clinical defects in latex surgical gloves; the ECT is significantly more sensitive and provides a gauge of the cross-sectional area of the defect. Interbrand differences in self-sealing properties of surgical gloves were evidenced and may be clinically relevant after glove perforation.
A Minimally Invasive Approach to Bile Peritonitis after Blunt Liver Injury
Authors: Griffen Margaret , Ochoa Juan , Boulanger Bernard R.
Published: November 2022

The advent of nonoperative management of liver injuries has made it imperative that surgeons be familiar with the potential delayed complications of this approach. In this report, we describe a minimally invasive strategy for the management of bile peritonitis following nonoperative management of blunt liver injuries. Two cases are presented in which bile peritonitis with massive bile ascites was managed with laparoscopic localization and drainage of the bile leak, irrigation of the peritoneal cavity, and postoperative endoscopic retrograde cholangiography with bile duct stenting. In both cases the bile leak ceased, and the patients recovered without adverse sequelae. The combination of laparoscopic surgery and endoscopic stenting provides a minimally invasive approach to this entity.
Opioid and Benzodiazepine Withdrawal Syndrome in Adult Burn Patients
Authors: Brown Craig , Albrecht Roxie , Pettit Herb , Mcfadden Toni , Schermer Carol
Published: November 2022

The prolonged use of continuous intravenous sedation [benzodiazepines (BZDs)] and pain medication [opioids (OPs)] is now common in intensive care units. Few studies have evaluated the characteristics that may lead to an acute withdrawal syndrome when these long-term medications are withdrawn. Those studies that have made recommendations for weaning rates to prevent withdrawal have given these recommendations with minimal data to support their recommendations. The purpose of this study was to retrospectively review the records of adult burn patients for the presence of acute BZD or OP withdrawal syndrome and to characterize whether patterns of BZD or OP administration or weaning rates contribute to the development of acute withdrawal syndrome. We found no relation of acute withdrawal syndrome to peak dose, total dose, or duration of dose of BZD/OP before the terminal withdrawal phase. There was a significant relationship between the rate of BZD/OP weaning in the terminal drug withdrawal phase and the percentage of days that patients experienced withdrawal symptoms ( P < 0.005). Those patients who underwent a prolonged terminal weaning from these medications experienced fewer symptoms. The optimal rate of weaning that would allow decreased ventilator and intensive care unit length of stay without development of acute withdrawal symptoms is yet to be determined.
Pancreatic Carcinoma Deemed Unresectable at Exploration May be Resected for Cure: An Institutional Experience
Authors: Chao Celia , Hoffman John P. , Ross Eric A. , Torosian Michael H. , Eisenberg Burton L.
Published: November 2022

Only a minority of patients with a diagnosis of pancreatic adenocarcinoma (PA) have disease amenable to curative resection. Between April 1987 and March 1999, 40 patients with pancreatic adenocarcinoma deemed unresectable at exploration at other institutions were considered for neoadjuvant treatments and then re-evaluated for possible re-exploration. We retrospectively compared the clinical outcomes, including overall survival (OS), among three groups: Group A, 22 previously unresectable patients who were subsequently successfully resected, 20 after induction therapy; Group B, 31 patients who received preoperative chemoradiotherapy before their only operation; and Group C, 33 patients who were primarily resected, 27 of whom were then treated with adjuvant therapy. Of those resectable from Group A, 5 required portal venorraphy and 3 had hepatic artery reconstruction. Eighteen of the 40 patients were unresectable because of progression of disease with a mean OS of 8 months; 12 were assessed at second laparotomy; 6 were excluded from second operation on the basis of preoperative imaging studies. Kaplan-Meier curves showed no differences in OS among the three groups: OS in Group A was 34 months; Group B, 21; and Group C, 13 ( P = 0.15). Margin status was comparable in all three groups ( P = 0.52). As expected, nodal positivity was greatest in Group C ( P = 0.001). There were no operative mortalities in Group A, and the morbidity rate was comparable with that of Groups B and C. Upon re-evaluation, many tumors (54%) previously deemed “unresectable” were surgically extirpated for cure with a median survival comparable with that of patients who did not undergo previous exploration.
Hypocaloric Parenteral Nutrition Support in Elderly Obese Patients
Authors: Liu Katherine J.M. , Cho Moon Ja , Atten Mary Jo , Panizales Evangeline , Walter Robert , Hawkins Debra , Donahue Philip A.
Published: November 2022

Hypocaloric nutritional support has been successfully used to achieve positive nitrogen balance in obese patients. However, advanced age is associated with changes in substrate metabolism. To evaluate the efficacy of this practice in elderly patients, we retrospectively reviewed 30 obese patients requiring parenteral nutrition support. Total caloric requirements (TCR) were calculated on the basis of the Harris-Benedict equation. Patients were given a minimum of 1.5 g/kg/day protein, 75 per cent of TCR when current body weight was >120 and ≤150 per cent of ideal body weight (IBW), and 60 per cent of TCR if current body weight was >150 per cent of IBW. The patients were divided into two groups: Group I (N = 18) patients were age <60 and Group II (N = 12) patients were ≥60 years of age. Only one of the Group I patients (143.2 ± 25.7% IBW, received 18.2 ± 3.7 kcal/kg/day and 1.6 ± 0.4 g/kg/day protein), but five of the Group II patients (141.3 ± 14.4% IBW, received 18.3 ± 2.6 kcal/kg/day and 1.7 ± 0.3 g/kg/day protein), had negative nitrogen balance ( P = 0.025). Apparently, elderly obese patients have limited capacity to mobilize their fat stores as energy sources and may continue to undergo protein catabolism with hypocaloric high-protein nutrition support. Therefore, this form of nutritional support should be used with caution in elderly obese patients.
Seroma Formation after Breast Cancer Surgery: Incidence and Predicting Factors
Authors: Woodworth Philip A. , Mcboyle Marilee F. , Helmer Stephen D. , Beamer R. Larry
Published: November 2022

The pathophysiology of seroma formation has yet to be determined. Therefore, the present study was undertaken to calculate the incidence of postoperative seromas after definitive breast cancer operations utilizing electrocautery dissection. Additionally, we attempted to identify risk factors associated with seroma development and to examine seroma formation in relation to operative procedure. A retrospective review of 252 breast cancer operations was undertaken. Patients were subdivided by operative procedure: modified radical mastectomy (MRM; n = 148), breast preservation with axillary node dissection (n = 64), or MRM with immediate reconstruction (n = 40). Electrocautery was used in development of skin flaps. Seromas developed in 39 of the 252 operations for an incidence of 15.5 per cent. Seroma formation was significantly lower in those patients receiving MRM with immediate reconstruction than in those receiving MRM (2.5% vs 19.6%; P = 0.009) and tended to be lower than for patients receiving breast preservation with axillary node dissection (14.06%; P = 0.052). Neoadjuvant chemotherapy was performed in 18 patients, of whom 6 developed seromas ( P = 0.030). The incidence of postoperative seromas was low despite the use of electrocautery. An association of postoperative seromas with neoadjuvant chemotherapy was noted. Additionally, it appears that immediate reconstruction may reduce the incidence of postoperative seromas, presumably by filling the dead space in the chest wall.
Incidence and Significance of Lobar Atelectasis in Thoracic Surgical Patients
Authors: Uzieblo Matthew , Welsh Robert , Pursel Stewart E. , Chmielewski Gary W.
Published: November 2022

Lobar atelectasis, defined by complete lobar collapse and mediastinal shift on chest roentgenogram, represents one extreme form of postoperative atelectasis. We have evaluated the incidence and clinical significance of lobar atelectasis in a thoracic surgical patient group. A retrospective review was done of patients who underwent pulmonary resection over a 2-year period to determine patient characteristics, contributing comorbidities, and associated perioperative care factors. Lung resections were performed for both benign and malignant disease through open or video-assisted techniques. One hundred eighty patients had pulmonary resection, 101 males and 79 females, and they were divided into three groups: I, no complications (112 patients, 62%); II, complications unrelated to lobar atelectasis (60 patients, 33%); and III, complications of lobar atelectasis (8 patients, 5%). There was one death in the series, in the lobar atelectasis group (III). Mean age for the entire group was 64.5 ± 12.5 years; however, patients in Groups II (67.3 years) and III (69.6 years) were significantly older than in Group I ( P < 0.02). Mean hospital length of stay in Group I was 6 ± 3 days, whereas that in Group II was 13 ± 12 days ( P < 0.001), and in Group III it was 27 ± 31 days ( P < 0.001). In addition, patients who developed lobar atelectasis were more likely to be male (88% vs 48%, P = 0.034), had a longer ICU length of stay ( P < 0.001), were more likely to have two or more comorbidities ( P < 0.05), and had a lower forced expiratory volume in 1 second (2.34 ± 0.90 vs 1.96 ± 0.63). All patients in the lobar atelectasis group were operated on for malignancy, but this was not significantly different from the other groups. None of the 16 patients who had thoracoscopy developed lobar atelectasis, but this also was not a significant finding. We conclude that severe postoperative atelectasis occurs as lobar atelectasis in approximately 5 per cent of patients who undergo pulmonary resection and significantly adds to the intensive care unit and hospital length of stay. The etiology of lobar atelectasis appears to be multifactorial and warrants further study to define mechanisms of occurrence and their prevention.
Effect of Magnetic Stimulation on the Contractile Activity of the Rectum in Humans
Authors: Shafik Ahmed , El-Sibai Olfat
Published: November 2022

Magnetic stimulation (MS) has been used to activate the neuromuscular tissue by inducing an electric field. Based on the results of a recent study on a canine model (Eur Surg Res 1998;30:268–72), which demonstrated that sacral MS effected a rectal and vesical pressure rise and a drop of rectal neck (anal canal) pressure, thereby achieving evacuation, the test was performed on 28 healthy volunteers (mean age, 36.6 years; 18 men and 10 women). The rectal, rectal neck, and vesical pressures were recorded during sacral MS with a magnetic coil while the rectum was empty and distended by a balloon. Electromyographic activity of the two rectus abdominis muscles was determined to exclude the possible interference of intra-abdominal pressure with the MS recordings. Stimulation parameters were set at 70 per cent intensity, 40-Hz frequency, and 1-to 2-second burst length. Sacral MS effected significant rectal and vesical pressure rise ( P < 0.01 and P < 0.01, respectively) and drop of rectal neck pressure ( P < 0.01). Intermittent stimulation induced balloon expulsion from the rectum. The two rectus abdominis muscles did not show change in electromyographic activity during MS, indicating that the rectal and vesical pressure rise was not due to increased intra-abdominal pressure. Sacral MS induced rectal evacuation with no adverse effects. The method is simple, easy, safe, and noninvasive and is suggested to be applied for the treatment of the inertic or neuropathic rectum. As the vesical pressure proved to be elevated too, MS might also be used for rectal and vesical evacuation in patients with spinal cord lesions.
Management of Cystic Neoplasms of the Pancreas
Authors: Box J. Craig , Douglass Harold O.
Published: November 2022

Cystic lesions of the pancreas are encountered frequently in clinical practice. Cystic neoplasms of the pancreas are much less common. In order to diagnose and most effectively treat these lesions, the surgeon must understand their clinical presentation in order to plan appropriate preoperative evaluation and therapeutic intervention. The following is a descriptive outline of the most common types of cystic neoplasms of the pancreas and a discussion of their preoperative, intraoperative, and postoperative management. The goal of the paper is to provide a functional understanding of cystic neoplasms of the pancreas so that they may be recognized and appropriately treated.
Appendicitis in Pregnancy
Authors: Tracey Michelle , Fletcher H. Stephen
Published: November 2022

Appendicitis continues to be the most common nonobstetric surgical diagnosis in pregnancy. Historically, this diagnosis has been associated with an increased risk of fetal loss as well as maternal morbidity. The physiologic and anatomic changes in pregnancy have been thought to obscure and thus delay the diagnosis of acute appendicitis, contributing to its increased risk in pregnancy. Such increased risks have been well reported in literature. To further evaluate the overall incidence, to determine the factors contributing to delay in diagnosis, and to assess overall outcomes in appendicitis in pregnancy, we performed a retrospective contemporary evaluation of pregnant patients with the diagnosis of acute appendicitis during the period 1991–1998. Twenty-two patients had the combined admitting diagnoses of pregnancy and acute appendicitis among 44,845 deliveries for the same time period (incidence, 0.05%). Gestational stage at diagnosis was the first trimester in 5 patients (22%), second trimester in 6 patients (27%), and third trimester in 11 patients (50%). Nineteen patients (86%) had pathologically proven acute appendicitis. Sixteen patients (73%) presented with less than 24 hours of abdominal symptoms. Seventeen patients (77%) presented with findings of rebound and guarding on initial physical examination. Fifteen patients (68%) were taken to the operating room within 24 hours of presentation. Of these, 10 patients (68%) had acute perforated appendicitis. Overall, there were 12 cases of perforated appendicitis (55%), which is an incidence higher than what has been reported in literature. There were no instances of fetal mortality. Preterm labor occurred in 5 patients, all in their third trimester with perforated appendicitis. Our study found that our population paralleled the incidence of gestational appendicitis of 0.05–0.07 per cent; physical examination on presentation was the most reliable diagnostic tool for appendicitis; and there is a higher incidence of perforation with increased gestational age, which does not result in increased fetal mortality.
Do Cytokeratin-Positive-Only Sentinel Lymph Nodes Warrant Complete Axillary Lymph Node Dissection in Patients with Invasive Breast Cancer?
Authors: Teng Steven , Dupont Elisabeth , Mccann Christa , Wang Jessica , Bolano Monica , Durand Kara , Peltz Eric , Bass Siddharth S. , Cantor Alan , Ku Ni Ni , Cox Charles E.
Published: November 2022

The small number of nodes harvested with lymphatic mapping and sentinel lymph node (SLN) biopsy has allowed a more detailed pathologic examination of those nodes. Immunohistochemical stains for cytokeratin (CK-IHC) have been used in an attempt to minimize the false negative rate for SLN mapping. This study examines the value of CK-IHC positivity in predicting further lymph node involvement in the axillary basin. From April 1998 through May 1999, 519 lymphatic mappings and SLN biopsies were performed for invasive breast cancer. SLNs were examined by imprint cytology, hematoxylin and eosin (H&E), and CK-IHC. Patients with evidence of metastatic disease by any of the above techniques were eligible for complete axillary node dissection (CAND). The frequency with which these modalities predicted further lymph node involvement in the axillary basin was compared. Of the 519 lymphatic mappings, 39 patients (7.5%) had a CK-IHC-positive-only SLN. Five (12.8%) of these 39 patients had at least 2 SLNs positive by CK-IHC. Twenty-six of the CK-IHC-positive-only patients underwent CAND. Three of these 26 patients (11.5%) had additional metastases identified after CAND. The sensitivity levels with which each modality detected further axillary lymph node involvement were as follows: CK-IHC, 98 per cent; H&E, 94 per cent; and imprint cytology, 87 per cent. A logistic regression to compare the prognostic value of the three modalities was performed. All were significant, with odds ratios of 19.1 for CK-IHC ( P = 0.015), 5.3 for H&E ( P = 0.033), and 3.86 for imprint cytology ( P = 0.0059). These data validate the enhanced detection of CK-IHC for the evaluation of SLNs. Detection of CK-IHC-positive SLNs appears to warrant CAND in patients with invasive breast cancer. However, the therapeutic value of CAND or adjuvant therapies based on CK-IHC-positive SLNs would be best answered by prospective randomized trials.
A Structured Curriculum for Improved Resident Education in Statistics
Authors: Cheatham Michael L.
Published: November 2022

Many resident physicians do not receive sufficient education in statistical theory and study design to allow them to effectively interpret and apply the medical literature to patient care. A survey of 62 surgical residency programs identified that only 33 per cent include formal statistics teaching in their curricula. A structured curriculum was formulated to introduce surgical residents to basic statistical theory, common statistical tests, and study design. Lectures were integrated into an existing monthly journal club in which manuscripts reviewed were used to illustrate the statistical concepts taught. Knowledge improvement was determined using a multiple choice test given before and after completion of the curriculum. Mean test scores increased significantly as a result of the curriculum ( P < 0.004). Formal statistics education using a structured curriculum significantly improves resident physician knowledge of statistical theory and study design. Such teaching can be easily integrated into a residency program's existing curriculum.
Intraoperative Ultrasound (IOUS) is Essential in the Management of Metastatic Colorectal Liver Lesions
Authors: Cervone Agostino , Sardi Armando , Conaway Gail L.
Published: November 2022

Metastatic tumors to the liver account for the majority of hepatic neoplasms. Improvement in resection has been shown to be beneficial and has remained the treatment of choice, carrying a 5-year survival rate of approximately 20 to 30 per cent. In evaluating candidates for surgery, intraoperative assessment for resectability is a key factor and dictates surgical approach, as well as patient prognosis. Historically, imaging techniques such as CT scan, magnetic resonance imaging, and CT arterial portography (CTAP) have been used in preoperative evaluation. However, the sensitivities of these diagnostic tools have been found to be less than optimal. Intraoperative ultrasound (IOUS) has emerged as an important tool in accurately staging metastatic liver disease with a sensitivity of 98 per cent. From 1994 to 1996, 23 patients have undergone IOUS for evaluation of suspected liver neoplasms in an ongoing prospective study. All patients had colorectal carcinoma. All patients received preoperative CT scan, and 11 patients with positive CT scans had CTAP. Fifteen patients were found to have colorectal metastasis to the liver. Surgical management in 7 of the 15 patients was modified because of the use of IOUS. Two patients were found to have unresectable disease thus abandoning hepatic resection, two were found to have additional lesions undetected by preoperative evaluation and were resected, and in two patients margins of resection were changed. One patient was found to have benign hepatic cysts, and no resection was performed. The use of IOUS modified the management of 44 per cent of our patients with liver metastases. IOUS should be routinely used in patients undergoing liver resection for metastatic liver disease.
One-Stage Resection and Primary Anastomosis following Acute Obstruction of the Left Colon for Cancer
Authors: Chiappa Antonio , Zbar Andrew , Biella Francesca , Staudacher Carlo
Published: November 2022

The purpose of this study was to analyze the outcome in patients with acute obstruction of the left colon for cancer and treated by intraoperative decompression, on-table lavage, resection, and primary anastomosis. Between March 1992 and May 1998, 50 patients with acute obstruction of the left colon for cancer underwent surgery. Of these, 39 patients (25 men and 14 women; mean age, 65 years; range, 23–89) were treated with intraoperative decompression, on-table lavage, resection, and primary anastomosis. Six patients (15%) had fecal localized peritonitis. Left colectomies were performed in 16 patients (32%), partial colectomies in 19 patients (38%), and anterior resections in 4 patients (8%). The primary anastomosis was intraperitoneal in 29 patients (74%) and below the peritoneal reflection of the rectum in 10 (26%). The postoperative course was uneventful in 30 of the 39 cases. One patient (3%) died (within 30 days from surgery) from septic shock and multiple organ failure syndrome. Anastomotic leakage was observed in 2 patients (6%). An intraabdominal abscess occurred in one case (3%). Other common complications included wound infections in 3 patients (8%). This experience suggests that intraoperative decompression, on-table lavage, resection, and primary anastomosis can be performed safely in selected patients with acute obstruction of the left colon for cancer than in those with an anastomosis in the nondiverted colon. Anastomosis below the peritoneal reflection is also not a contraindication.
The Influence of Anesthetic Technique on Perioperative Blood Pressure Control after Carotid Endarterectomy
Authors: Eibes Todd A. , Gross William S.
Published: November 2022

The optimal anesthetic for use during carotid endarterectomy has been a matter of debate for three decades. The goal of this study is to evaluate the influence of anesthetic technique on perioperative hemodynamic instability after carotid endarterectomy. This study is a retrospective chart review and was performed in a community teaching hospital. All consecutive patients undergoing carotid endarterectomy over a 2-year period at Providence Hospital were reviewed. One hundred ninety-eight patients underwent 203 carotid endarterectomies. Two patients were excluded because of combined coronary artery bypass grafting. Patients underwent carotid endarterectomy and were divided into two groups on the basis of use of general or regional anesthesia. Blood pressure was recorded hourly for the subsequent 24 hours, and the doses of vasoactive medications received to maintain the blood pressure within 25 mm Hg of preoperative levels were recorded. Patients receiving general anesthesia were found to require significantly more sodium nitroprusside for control of hypertension compared with those receiving regional anesthesia (72.1 ± 14.5 μg/kg vs 20.2 ± 6.6 ug/kg; P = 0.001) in the first 8 postoperative hours. No significant differences were noted in the doses of any other vasoactive medications used. No differences were found in the subsequent 16-hour period in doses of vasoactive medications. Patients suffering myocardial infarctions were found to receive higher doses of nitroglycerine, but no differences were noted in any other vasoactive medication used based on complications. Length of stay was longer in the general anesthesia group compared with the regional anesthesia group for both the intensive care unit (1.59 ± 0.13 days vs 1.08 ± 0.03 days; P = 0.001) and total hospital stay (5.8 ± 0.03 days vs 4.5 ± 0.02 days; P = 0.003). Regional anesthesia required lower doses of antihypertensive medication in the early postoperative period when compared with general anesthesia. The doses of vasoactive medications used had no significant impact on the complication rate. Regional anesthesia allowed for shorter stay in both the intensive care unit and total hospital stay.
Should Needle Localization Breast Biopsy Give Way to the New Technology; the Advanced Breast Biopsy Instrumentation
Authors: Hawasli Abdelkader M.D. , Zonca Steve , Watt Christean , Rebecca Alana
Published: November 2022

Between July 1995 and June 1997, 114 consecutive women underwent 118 breast biopsies for nonpalpable lesions. A limited procedure room and local anesthesia were used in 96.5 per cent of patients. Intravenous access was not established in 95 per cent of patients. Oral diazepam was given to 51 per cent of patients. Needle localization technique was used with a success rate of 97.5 per cent and average operative time of 18 minutes. Breast carcinoma was found in 29 (24.6 per cent) biopsies. A review of 99 of the 118 mammograms showed only 45 per cent of the lesions being amenable to the new technology, the advanced breast biopsy instrumentation. Advantages of the needle localization include short operative time; supine position for the patient; easy access to control bleeding; ability to choose a cosmetic site for the skin incision; minimal tissue removal before reaching the lesion; ability to maintain a sterile field; and applicability to almost any mammographic lesion identified, whether single or multiple. Disadvantages include the need for a separate procedure to place the wire and potential of missing the lesion in 2.5 per cent, requiring additional surgery.
Iliac Vein Compression Syndrome: A New Method of Treatment
Authors: Baron Howard C. , Shams Joseph , Wayne Michael
Published: November 2022

Iliac vein compression syndrome (May-Thurner syndrome) is caused by compression of the left iliac vein against the pelvic rim by the right iliac artery. Serious vascular sequelae to the leg can result if this is not recognized and corrected in a timely fashion. The condition, often underdiagnosed, is thought to be present in approximately 20 per cent of the adult population. Previously, a major vascular operation with a significant hospital stay was required to correct this compression. As a nonsurgical option, we elected balloon dilation of the stenosed iliac vein, with insertion of a venous stent to maintain the restored lumen. Two patients who had this procedure have been followed for 12 months; venograms show continued patency of the iliac vein with no pressure gradient present. This procedure is safe and cost effective, and it requires a minimal hospital stay.
Sentinel Lymph Node Biopsy in Breast Cancer
Authors: Sakorafas George H. , Tsiotou Adelais G.
Published: November 2022

One of the most important prognostic indicators in patients with breast cancer is axillary lymph node status. Sentinel lymph node (SLN) biopsy has emerged as a potential alternative to routine axillary dissection in clinically node-negative early breast cancer. This procedure requires a specialized but multidisciplinary approach utilizing the surgeon, nuclear radiologist and pathologist. SLN biopsy allows adequate assessment of the axillary nodal status in patients with early breast cancer, with minimal—if any—morbidity. Blue dye and lymphoscintigraphy are complementary techniques, and the success rate is maximized when the two methods are used together. Focused histopathologic examination on one or two lymph nodes most likely to contain metastases [SLN(s)], using serial sectioning and immunohistochemical techniques, allows an improved staging to be performed. Detection of metastases on SLN(s) is not only a prognostic indicator, but it also dictates whether the patient should receive further surgery and adjuvant chemotherapy. Until data regarding the long-term results of the SLN biopsy are available, this method should be considered investigational and be performed by surgeons experienced in this technique to achieve a failure rate of less than 2 per cent.
Sarcoidosis of the Pancreas: Case Report and Review of the Literature
Authors: Bacal Daniel , Hoshal Verne L. , Schaldenbrand John D. , Lampman Richard M.
Published: November 2022

Sarcoidosis involving the pancreas is rare. Patients can present with symptoms that mimic pancreatic cancer. We report a case of a male patient with clinical and radiographic findings suggestive of pancreatic cancer as the initial manifestation of sarcoidosis.
Treatment Options for Perianal Bowen's Disease: Survey of American Society of Colon and Rectal Surgeons Members
Authors: Cleary R.K. , Schaldenbrand J.D. , Fowler J.J. , Schuler J.M. , Lampman R.M.
Published: November 2022

The aim of this study was to determine current management practices of physicians caring for patients with perianal Bowen's disease. A questionnaire was sent to 1499 members listed in the 1997 American Society of Colon and Rectal Surgeons Directory asking them how many patients they have treated and which operative or nonoperative treatment option they choose for small (≤3 cm), large (> 3 cm), and microscopic lesions. Of 1499, 663 (44.2%) surgeons responded. Not all respondents answered each item. Seventy-five per cent of surgeons surveyed (n = 653) devote greater than 75 per cent of their practice to colon and rectal surgery. Of 642 respondents, 552 (86%) managed a total of <10 patients, and 90/642 (14%), ≥10 patients. Ninety-six per cent of respondents use wide local excision for patients with small lesions. Eighty-seven per cent of respondents use wide local excision for patients with large lesions. Seventy-four per cent treat patients with microscopic disease conservatively and without wide excision. The majority of surgeons caring for patients with perianal Bowen's disease are performing wide local excision for both small and large lesions. Microscopic disease was usually treated conservatively with observation alone.
Gastric Stromal Tumor
Authors: Parithivel Vellore S. , Niazi Masooma , Shah Ajay K. , Ha Joseph P. , Mailapur Ravindra V. , Kaul Kamlesh , Remey Prosper , Albu Eugene
Published: November 2022

Gastric stromal tumors display a bewildering array of immunohistological and ultrastructural features as well as variable biological behavior. These tumors are rare as compared with ones that arise from the gastric epithelium. Moreover, they have been the subjects of controversy because of their uncertain histogenesis. We report the pathological features of gastric stromal tumors we recently encountered in three patients.
Accurate Placement of Microvascular Guide Sutures
Authors: Dardik Alan , Ballermann Barbara J. , Williams G. Melville
Published: November 2022

A simple technique to accurately place initial microvascular guide sutures is described. Enhanced suture placement enables anastomosis construction in situations in which the clamp must be placed very close to the vessel end or if the vessel lumen is distorted or poorly visualized. Because this technique eliminates the need for retraction on the guide suture tails, it is particularly useful for solo microvascular surgeons.
Acute Gastric Dilatation Revisited
Authors: Todd S. Rob , Marshall Gary T. , Tyroch Alan H.
Published: November 2022

First described by S.E. Duplay in 1833, acute gastric dilatation has since been well documented in the literature. Several theories of the pathogenesis of acute gastric dilatation have been postulated. In 1842, Karl Freiherr von Rokitansky described the superior mesenteric artery syndrome, followed by W. Brinton in 1859 with the atonic theory. C.R. Morris et al. introduced debilitation and anesthesia as predisposing factors. Although rare, gastric necrosis is the most severe consequence of acute gastric dilatation. Vascular insufficiency secondary to increased intragastric pressure is the critical factor. We report an unusual case of acute gastric dilatation with subsequent necrosis of uncertain etiology.
Bile Duct Carcinoma: Trends in Treatment in the Nineties
Authors: Reed Donald N. , Vitale Gary C. , Martin Robert , Bas Heidi , Wieman T. Jeffery , Larson Gerald M. , Edwards Michael , Mcmasters Kelly
Published: November 2022

Surgical resection provides the only known chance of cure for cholangiocarcinoma, and even then the 5-year survival is only 10 to 20%, and only one-third of patients are resectable for cure at the time of diagnosis. In recent years we have had considerable experience with endoscopic stenting to palliate common bile duct cancers. This has prompted us to evaluate our results for both endoscopic and surgical treatment of cholangiocarcinoma.

From January 1990 through June 1999, we reviewed our endoscopic retrograde cholangiopancreatography registry and the hospital records for patients we treated for cholangiocarcinoma. Fifty patients were identified: 45 with cholangiocarcinoma and five with gallbladder cancer (who were excluded). The surgical group consisted of 16 patients: in 14 patients, resection for cure was possible whereas two had palliative procedures. There was one mortality (6%) and the median survival was 16 months. There have been no long-term surgical survivors, but 2 patients are alive at 24 months. We treated 29 patients with advanced disease with endoscopic stents (the endoscopic group) mainly for relief of obstructive jaundice. Six of 29 patients in the endoscopic group were critically ill and died in less than 4 weeks, whereas 23 patients who were in better condition survived for a mean of 10 months (range 2–84 months). We conclude that for common duct bile cancer surgical resection remains the treatment of choice but is applicable in only 30 to 35 per cent of cases. Endoscopic stenting effectively relieves jaundice and can provide long-term palliation comparable with surgical bypass; 12 of 29 patients in our endoscopic group survived 12 months or longer, and one is alive at 84 months after initial stenting.
Surgical Repair of Inguinal Hernia: Tension Free Technique with Prosthetic Materials (Gore-Tex Mycro Mesh Expanded Polytetrafluoroethylene)
Authors: Athanasakis Elias , Saridaki Zenia , Kafetzakis Alexandros , Chrysos Emmanuel , Prokopakis George , Vrahasotakis Nickolaos , Xynos Evangelos , Chalkiadakis George , Zoras Odysseas
Published: November 2022

The purpose of this study is to report the results of a tension-free repair technique using expanded polytetrafluoroethylene Gore-Tex Mycro Mesh in patients with inguinal hernias. Over 3 years, 104 patients have undergone the aforementioned procedure for 118 hernias (85 indirect and 33 direct) in our clinic. Ninety-three of the patients were operated for the first time, whereas the remainder of them were operated for hernia recurrence. Fourteen patients had bilateral hernias, and six had incarcerated ones. The median patient's age was 53 years. Eighty-three patients were operated under general and 21 under local or epidural anesthesia. One hundred and two patients were offered a one-day surgery procedure, but three were readmitted with wound infection. Two of these patients were conservatively cured, and the third was submitted to mesh removal. Two patients developed hematoma in the scrotum and were discharged a week later after the absorption of the hematoma. All of the patients except the one who was submitted to mesh removal returned to normal life within a week after the operation. During the follow-up period, none of our patients experienced hernia recurrence. Our results are in accordance with those of the world literature. We perform the tension-free hernia repair by using the expanded polytetrafluoroethylene mesh in our patients because we believe it is a safe procedure without significant postoperative morbidity and with no hernia recurrences.
Surgical Management of Malignant Melanoma Using Dynamic Lymphoscintigraphy and Gamma Probe-Guided Sentinel Lymph Node Biopsy: The Emory Experience
Authors: Murray Douglas R. , Carlson Grant W. , Greenlee Robert , Alazraki Naomi , Fry-Spray Cynthia , Hestley Andrea , Poole Rufus , Blais Michel , Timbert D. Scott , Vansant John
Published: November 2022

Sentinel lymph node (SLN) biopsy is revolutionizing the surgical management of primary malignant melanoma. It allows accurate nodal staging which targets patients who may benefit from regional lymphadenectomy and systemic therapy. This is a retrospective review of patients treated at Emory University for stage I and II malignant melanoma with gamma probe-guided SLN biopsy from 1/1/94 to 6/30/98. Three hundred sixty patients (males 228, females 132) were identified. Primary melanoma sites included: head and neck 58, trunk 148, and extremities 154 (upper 71, lower 83). Primary tumor staging was T19, T2134, T3153, and T464. SLNs were successfully identified in 99.7 per cent of patients and 98.9 per cent of nodal basins mapped. In 275 (76.6%) cases a single draining nodal basin was identified. In 84 (23.3%) cases there were multiple draining nodal basins. Positive SLNs were identified in 63 patients (17.5%). SLN positivity by tumor staging was T10 per cent, T29.0 per cent, T322.2 per cent, and T426.6 per cent. The overall recurrence rate was 11.9 per cent. Recurrences by SLN status were SLN+, 27 per cent, and SLN-, 8.8 per cent. Regional recurrence occurred in 7 (2.4%) of the 297 with negative SLN biopsies and 7 (11.1%) of the 63 with positive SLN biopsies. Dynamic lymphoscintigraphy and gamma probe-guided SLN localization was successful in more than 98 per cent of cases. Patients with negative SLN biopsies have a low risk of recurrence.