bluuebunny/crossref_metadata_2025 huggingface dataset:
Susceptibility of nucleotide-binding oligomerization domain 2 mutations to Whipple’s disease
Authors: Williamson Katrina A , Yun Mark , Koster Matthew J , Arment Courtney , Patnaik Asha , Chang Tara W , Bledsoe Adam C , Sae-Tia Sutthichai , Shah Aditya S , Samuels Jonathan , Davis John M , Yao Qingping
Published: July 2023

Objectives

Whipple’s disease (WD) results from infection of the bacteria Tropheryma whipplei (TW). This disease is characterized by macrophage infiltration of intestinal mucosa and primarily affects Caucasian males. Genetic studies of host susceptibility are scarce. Nucleotide-binding oligomerization domain containing protein 2 (NOD2) is an innate immune sensor, resides mainly in monocytes/macrophages and contributes to defence against infection and inflammatory regulation. NOD2 mutations are associated with autoinflammatory diseases. We report the association of NOD2 mutations with TW and WD for the first time.

Methods

A multicentre, retrospective study of three patients with WD was conducted. Patients received extensive multidisciplinary evaluations and were cared for by the authors. NOD2 and its association with infection and inflammation were schematically represented.

Results

All patients were Caucasian men and presented with years of autoinflammatory phenotypes, including recurrent fever, rash, inflammatory arthritis, gastrointestinal symptoms and elevated inflammatory markers. All patients underwent molecular testing using a gene panel for periodic fever syndromes and were identified to carry NOD2 mutations associated with NOD2-associated autoinflammatory disease. Despite initially negative gastrointestinal evaluations, repeat endoscopy with duodenal tissue biopsy ultimately confirmed WD. After initial ceftriaxone and maintenance with doxycycline and/or HCQ, symptoms were largely controlled, though mild relapses occurred in follow-up.

Conclusion

Both NOD2 and TW/WD are intensively involved in monocytes/macrophages. WD is regarded as a macrophage disease. NOD2 leucin-rich repeat–associated mutations in monocytes/macrophages cause functional impairment of these cells and consequently may make the host susceptible for TW infection and WD, especially in the setting of immunosuppression.
Epidemiology and Comparative Analysis of Outcomes of Intramedullary Spinal Cord Tumor Between Pediatric and Adult Patients
Authors: Umebayashi Daisuke , Naito Kentaro , Kurokawa Ryu , Endo Toshiki , Mizuno Masaki , Hoshimaru Minoru , Kim Phyo , Hida Kazutoshi , Takami Toshihiro ,   Neurospinal Society of Japan Intramedullary Tumor Study Collaborators
Published: July 2023

Study Design.

This was as clinical retrospective study.

Objectives.

We sought to evaluate the characteristics of Pediatric intramedullary spinal cord tumors (PISCTs) and to identify differences between pediatric and adult intramedullary spinal cord tumors.

Summary of Background Data.

PISCTs represent a rare clinical entity with limited evidence-base in the literature.

Methods.

This study is a subanalysis of the retrospective multicenter observational study authorized by the Neurospinal Society of Japan, including consecutive patients with spinal intramedullary tumors treated surgically at 58 institutions between 2009 and 2020. Data on 1080 intramedullary spinal cord tumors were obtained, consisting of 91 pediatric and 939 adult patients. Survival was compared using Cox hazard regression while clinical differences were evaluated using multivariable logistic regression that controlled for confounders.

Results.

Pediatric patients had a shorter overall, and progression-free, survival than adults. Pediatric patients with ISCTs were likely to have scoliosis [odds ratio (OR) = 6.49, 95% CI: 2.26–18.7], short preoperative symptom duration (OR = 0.99, 95% CI: 0.98–0.99), lower incidence of paresthesia (OR = 0.41, 95% CI: 0.22–0.77), higher incidence of paresis (OR = 2.10, 95% CI: 1.01–4.35), histopathology of astrocytoma (OR = 2.97, 95% CI: 1.19–7.43), and postoperative functional deterioration upon discharge (OR = 2.83, 95% CI: 1.43–5.58). Age was not a statistically significant prognostic factor of overall survival among the pediatric cohort.

Conclusion.

We found that the clinical characteristics of ISCTs differed between pediatric and adult patients. In terms of histopathological types, astrocytoma was most common in pediatric patients. ISCT occurring at an early age may not be an indicator for poor prognosis.
The State of Genetics and Genomics Education in US Physician Assistant Programs
Authors: Patterson Wesley G. , Tribble Leta M. , Hopkins Casey S. , Fasolino Tracy K. , Ward Linda D.
Published: July 2023

Purpose

This study aimed to assess the current landscape of genetics-genomics education in physician assistant (PA) student training.

Methods

A 25-question electronic survey was emailed to program directors of the 273 accredited PA programs. Questions represented PA program demographics and 4 domains: curricular characteristics and perceived adequacy; content; curricular approaches and instructional methods; and intent, barriers, and perceived needs for an optimal curriculum.

Results

A total of 115 PA program representatives (42%) returned the survey. More than two-thirds of responding programs do not require a prerequisite genetics course for matriculation. Most programs (48%) include 1 to 10 contact hours of genetics-genomics content and use various content delivery methods and approaches. Most programs (67%) use PA program faculty to teach genetics-genomics as part of one course or many courses throughout the curriculum (85%) using didactic lectures (97%). The most significant barrier to developing an optimal curriculum is an already overloaded curriculum (71%). Physician assistant educators welcome supportive resources, such as genetic case studies (96%).

Conclusions

The study findings elucidate the current state of genetics-genomics education in PA programs. Every responding program reports that genetics-genomics is integrated into their curriculum; however, no standardization exists between programs. Although medical genetics-genomics has changed and advanced rapidly since a similar survey was conducted 14 years ago, the number of contact hours is unchanged, and genetics-genomics content is less dispersed throughout PA curricula. To create genetic-competent and genomic-competent PAs, education must evolve to stay current with ongoing advancements in genomic science.
Contribution of carbon inputs to soil carbon accumulation cannot be neglected
Authors: He Xianjin , Abramoff Rose , Abs Elsa , Georgiou Katerina , Zhang Haicheng , Goll Daniel S.
Published: July 2023

In a recently published paper (1), the authors report that microbial carbon use efficiency (CUE) is the primary determinant of global soil organic carbon (SOC) storage and that the relative impact of plant carbon inputs on SOC is minor. While soil microbes undoubtedly play an important role in soil organic carbon cycling, we are concerned about the robustness of the approach taken by Tao et al. (1) and highlight potential biases in their analyses that may lead to misleading, model-dependent results.
Barriers and facilitators of physical activity in adults with severe haemophilia: A qualitative study
Authors: Cotino Claudia , Pérez‐Alenda Sofía , Cruz‐Montecinos Carlos , López‐Bueno Rubén , Núñez‐Cortés Rodrigo , Suso‐Martí Luís , Mendez‐Rebolledo Guillermo , Andersen Lars Louis , Casaña José , Calatayud Joaquín
Published: July 2023

Background

People with haemophilia (PWH) tend to be less physically active than the general population, but there is a lack of research on the specific barriers and facilitators affecting their participation in physical activities.

Objectives

This study aims to explore perceived barriers and facilitators to physical activity in severe PWH.

Design

An explorative qualitative study based on focus groups.

Methods

Four focus groups including 16 participants (severe haemophilia A patients) were conducted to examine the factors perceived as facilitators or barriers to haemophiliacs engaging in physical activity. One researcher conducted a thematic analysis of all data.

Results

Three themes were identified: body function, personal factors, and environmental factors. Key facilitators identified were access to prophylaxis treatment to reduce the risk of bleeding(s), the enjoyability of physical activity, fitness and health motives, social interaction, support, and low cost. PWH faced additional barriers to being physically active including hurtful joints, mobility issues, haemophilic arthropathy, dislike or disinterest, lack of motivation, fear of injury, tiredness, lack of time, lack of guidance, negative social influence, restriction, and lack of coordination of prophylaxis treatment.

Conclusion

This exploratory study demonstrated that participation in physical activity in PWH is influenced not only by their own abilities and attitudes, but also by external variables, including family, friends, healthcare professionals, structures, and communities. The results of this study may be used to assist caregivers and health professionals, inform programs, interventions, and policies to promote physical activity and health in severe PWH.
Deep learning of quantum entanglement from incomplete measurements
Authors: Koutný Dominik , Ginés Laia , Moczała-Dusanowska Magdalena , Höfling Sven , Schneider Christian , Predojević Ana , Ježek Miroslav
Published: July 2023

The quantification of the entanglement present in a physical system is of paramount importance for fundamental research and many cutting-edge applications. Now, achieving this goal requires either a priori knowledge on the system or very demanding experimental procedures such as full state tomography or collective measurements. Here, we demonstrate that, by using neural networks, we can quantify the degree of entanglement without the need to know the full description of the quantum state. Our method allows for direct quantification of the quantum correlations using an incomplete set of local measurements. Despite using undersampled measurements, we achieve a quantification error of up to an order of magnitude lower than the state-of-the-art quantum tomography. Furthermore, we achieve this result using networks trained using exclusively simulated data. Last, we derive a method based on a convolutional network input that can accept data from various measurement scenarios and perform, to some extent, independently of the measurement device.
Corrosion Electrochemistry of Chromium in Molten FLiNaK Salt at 600 °C
Authors: Chan Ho Lun , Romanovskaia Elena , Romanovski Valentin , Sur Debashish , Hong Minsung , Hosemann Peter , Scully John R.
Published: July 2023

The manuscript revisits the corrosion behavior of pure Cr in molten FLiNaK salt at 600 °C from the perspective of corrosion electrochemistry. In this work, the potential-dependent, rate-limiting charge-transfer, and salt film-mediated mass-transport controlled regimes of Cr corrosion in FLiNaK at 600 °C are investigated. The kinetic and thermodynamic parameters that limit electrodissolution and the consideration of grain orientation on these regimes are elucidated. At low Cr(III) concentrations, the corrosion process is governed by charge transfer control at low overpotentials and is crystal orientation dependent. However, when Cr(III) concentrations are high or when there is a high overpotential, the formation of a metal fluoride salt film on the Cr surface shifts the kinetic behavior to be governed by mass transport control at all anodic potentials with a surface morphology controlled by salt film deposition location and identity. Evan’s diagrams were developed to consolidate and elucidate these observations. These findings were supported by an examination of the post-corrosion microstructure, X-ray diffraction of solidified salts, and thermo-kinetics analysis in each corrosion regime.
Data from Using DEPendency of association on the number of Top Hits (DEPTH) as a complementary tool to identify novel colorectal cancer susceptibility loci.
Authors: Lai John , Wong Chi Kuen , Schmidt Daniel F. , Kapuscinski Miroslaw K. , Alpen Karen , Maclnnis Robert J. , Buchanan Daniel D. , Win Aung K. , Figueiredo Jane C. , Chan Andrew T. , Harrison Tabitha A. , Hoffmeister Michael , White Emily , Le Marchand Loic , Pai Rish K. , Peters Ulrike , Hopper John L. , Jenkins Mark A. , Makalic Enes
Published: July 2023

Abstract
Background: DEPendency of association on the number of Top Hits (DEPTH) is an approach to identify candidate susceptibility regions by considering the risk signals from overlapping groups of sequential variants across the genome.

Methods: We conducted a DEPTH analysis using a sliding window of 200 SNPs to colorectal cancer (CRC) data from the Colon Cancer Family Registry (CCFR) (5,735 cases and 3,688 controls), and GECCO (8,865 cases and 10,285 controls) studies. A DEPTH score >1 was used to identify candidate susceptibility regions common to both studies. We compared DEPTH results against those from conventional GWAS analyses of these two studies as well as against 132 published susceptibility regions.

Results: Initial DEPTH analysis revealed 2,622 (CCFR) and 3,686 (GECCO) candidate susceptibility regions, of which 569 were common to both studies. Bootstrapping revealed 40 and 49 candidate susceptibility regions in the CCFR and GECCO data sets, respectively. Notably, DEPTH identified at least 82 regions that would not be detected using conventional GWAS methods, nor had they been identified by previous CRC GWASs. We found four reproducible candidate susceptibility regions (2q22.2, 2q33.1, 6p21.32, 13q14.3). The highest DEPTH scores were in the HLA locus at 6p21 where the strongest associated SNPs were rs762216297, rs149490268, rs114741460, and rs199707618 for the CCFR data, and rs9270761 for the GECCO data.

Conclusions: DEPTH can identify candidate susceptibility regions for CRC not identified using conventional analyses of larger datasets.

Impact: DEPTH has potential as a powerful complementary tool to conventional GWAS analyses for discovering susceptibility regions within the genome.
Lnc-LRRTM4 promotes proliferation, metastasis and EMT of colorectal cancer through activating LRRTM4 transcription
Authors: Zhang Jingjie , Meng Xianmei , Zhou Yi , Jiang Zhengyu , Chen Hongsuo , Meng Zhiyi , Zhang Qi , Chen Weichang
Published: July 2023

Numerous mechanisms have shown that long noncoding RNAs (lncRNAs) promote the development of colorectal cancer (CRC), but the role of lnc-LRRTM4 in the progression of CRC remains unclear. In this article, we found that lnc-LRRTM4 was highly expressed in CRC tissues and cell lines and that lnc-LRRTM4 could promote the proliferation and metastasis of CRC cells. These consequences were achieved by lnc-LRRTM4 directly binding to the promoter of LRRTM4 to induce its transcription. Moreover, lnc-LRRTM4 enhanced the growth of CRC cells in vivo by promoting cell cycle progression and reducing apoptosis. Taken together, our results revealed that lnc-LRRTM4 promotes the proliferation and metastasis of CRC cells, suggesting that it may be a potential diagnostic and therapeutic target for CRC.
Snakes and Souks: Zoonotic pathogens associated to reptiles in the Marrakech markets, Morocco
Authors: Mendoza-Roldan Jairo Alfonso , Noll Louzada-Flores Viviane , Lekouch Nouha , Khouchfi Intissar , Annoscia Giada , Zatelli Andrea , Beugnet Frédéric , Walochnik Julia , Otranto Domenico
Published: July 2023

The world-famous markets of Marrakech, also known in Arabic as souks, harbor a vast diversity of reptiles that are sold for medicinal/magic/pet purposes or used for snake charming. This unique epidemiological context has never been studied considering the interactions of humans, reptiles, and zoonotic pathogens. Thus, the aim of this study was to identify the parasites and pathogens present in blood and feces associated with handled reptiles in the markets of Marrakech to assess the risk of zoonotic transmission within the reptile-human interface. Privately owned reptiles (n = 118), coming from vendors or snake charmers, were examined and blood and feces sampled. DNA was extracted and molecular screening (cPCR, nPCR, qPCR, dqPCR) was performed aiming to identify potentially zoonotic pathogens (i.e., Anaplasma/Ehrlichia spp., Rickettsia spp., Borrelia burgdorferi sensu lato, Coxiella burnetii, Babesia/Theileria spp., Cryptosporidium spp., Giardia spp., Leishmania spp., Cestoda). Overall, 28.9% (34/118) of reptiles were positive for at least one pathogen. In blood, Anaplasma spp. were detected in four snakes, with two Montpellier snakes positive for Anaplasma phagocytophilum, while Rickettsia spp. were detected in one Mediterranean chameleon and four puff adders. Leishmania tarentolae was molecularly detected in a Mediterranean chameleon and a Montpellier snake. In feces, the cox1 gene generated a myriad of sequences for nematodes, cestodes, fungi and bacteria. Importantly, Proteus vulgaris was identified from a Mediterranean chameleon. Cryptosporidium spp. nPCR yielded a positive sample (i.e., Cryptosporidium sp. apodemus genotype I) from a Moroccan worm lizard, as well as for bacteria such as Pseudomonas aeruginosa in an Egyptian cobra, and Morganella morganii from a puff adder. Results from this study demonstrated the risk of zoonotic transmission of microorganisms and parasites present in blood and feces from reptiles that are brought to the souks in Marrakech, Morocco, to be sold for medicinal purposes or used for snake charming, being in direct and straight contact with humans.
The crystal structure of 1-propyl-2-nitro-imidazole oxide, C6H9N3O3
Authors: Jun Yuan , Bingheng Wu , Yong Wang , Jianlong Wang , Duanlin Cao , Lizhen Chen
Published: July 2023

C6H9N3O3, monoclinic, P21/n (no. 14), a = 9.5584(4) Å, b = 6.7828(3) Å, c = 12.8337(6) Å, β = 103.8810(10)∘, V = 807.74(6) Å3, Z = 4, R

gt
(F) = 0.0455, wR

ref
(F
2) = 0.1166, T = 170.0 K.
Data farm: Information system for collecting, storing and processing unstructured data from heterogeneous sources
Authors: Levashkin Sergey Pavlovich , Ivanov Konstantin Nikolaevich , Kushukov Sergey Vladimirovich
Published: July 2023

The original information system «data farm» is presented. Today, the successful application of artificial intelligence algorithms, primarily deep learning based on artificial neural networks, almost completely depends on the availability of data. And the larger the amount of these data (big data), the better are the results of the algorithms execution. There are well-known examples of such algorithms from Facebook, Google, Microsoft, Yandex, etc. The data must contain both the training sample and the test one. Moreover, the data must be of good quality and have a certain structure, ideally, be labeled in order for the learning algorithms to work adequately. This is a serious problem requiring huge computational and human resources. This paper is dedicated to solve this problem. Today data farm is a rather complex information system built on a modular basis, similar to the well-known Lego constructor. Separate modules of the system are various modern algorithms, technologies and entire libraries of artificial intelligence, and all together they are designed to automate the process of obtaining and structuring high-quality big data in various subject domains. The system has been tested on data of COVID-19 in regions of Russia and countries around the world. In addition, a user-friendly interface for visualizing collected and processed on the farm data was developed. This makes it possible to conduct visual numerical experiments of computer simulation and compare them with real data, turning the farm into an intelligent decision support information system.
La tradición del doble en El otoño del patriarca
Authors: Motato C Hernando
Published: July 2023

El enfoque analítico de esta novela garciamarquiana está centrado en la forma en la que su autor recoge obras clave de la literatura y del pensamiento universales, tales como el poema del Gilgamesh, La comedia de las equivocaciones, de Shakespeare, y el texto Esaú y Jacob, de la Biblia, entre otros, a fin de darle un sentido paródico con las figuras del doble de dichas obras.  asimismo, retomo la presencia del doble en sus primeros cuentos: «La otra costilla de la muerte» y «Diálogo del espejo». A su vez, como también ese otro yo entre el médico y el cura en La hojarasca; igualmente, en la simetría de los espejos entre los hermanos gemelos de Cien años de soledad, hasta llegar al doble propiamente dicho en El otoño del patriarca, visto a través de la dualidad del poder entre Patricio Aragonés y el patriarca que es el punto culminante con el cual García Márquez cierra el horizonte estético en torno a la configuración del doble.
El vaivén del tiempo en “El tiempo recobrado”, de Ignacio Padilla
Authors: Lee Kakyung
Published: July 2023

Este estudio revisa “El tiempo recobrado”, el último cuento de Las antípodas y el siglo. Mediante el análisis del tiempo histórico y del tiempo mítico, se propone que el texto estaría en las antípodas de En busca del tiempo perdido de Marcel Proust. En oposición al protagonista de la novela francesa, el noble británico del cuento de Padilla amplia el tiempo histórico y pierde la oportunidad de rescatar el tiempo mítico. Se muestra también que hay una relación contraria más al interior del texto, en cuanto a la recuperación del tiempo, en la representación del autor-artista y en el acto de lectura.
Cruces genéricos y su dimensión política en Papeles de Pandora de Rosario Ferré
Authors: Bedoya Sindy Tatiana
Published: July 2023

El presente artículo analiza los cruces genéricos y discursivos presentes en tres relatos de Papeles de Pandora como parte de la propuesta estética y política de Ferré. A través de este proyecto, la autora cuestiona y denuncia, no solo los valores sociales hegemónicos que han condicionado a la mujer puertorriqueña y que han ocasionado una fragmentación en su identidad, sino también los valores culturales que han limitado el papel de la mujer en la escritura.
Transdisciplinariedad, contemporaneidad crítica, impacto académico global
Authors: Sedeño-Guillén Kevin
Published: July 2023

Este No. 35 contiene una sección monográfica titulada “Masculinidades e intimidades literarias en México durante el siglo XX/Masculinities and Literary Intimacies in 20th century Mexico”, a cargo de los profesores Jairo Antonio Hoyos y César Cañedo; una entrevista a la escritora cubana Karla Suárez, realizada por Lis García-Arango y René Camilo García-Rivera; y una reseña del libro La condición intelectual. Informe sobre la academia (2018), de raúl rodríguez freire, escrita por Wayleen Arrieta Ariza.
Desidentificaciones cuasi-cuir y otras estrategias para narrar la intimidad en Beso negro (1992), de Gilberto Flores Alavez
Authors: Dennstedt Francesca
Published: July 2023

La novela Beso negro (1992), de Gilberto Flores Alavez, documenta la realidad de habitar un cuerpo cuir y la posibilidad de representarlo en la esfera pública. A partir de esto, propongo analizar las estrategias de supervivencia utilizadas por el autor que responden a la experiencia de ser interpelado como un enfermo mental con inclinaciones homoeróticas cuando se le acusa de asesinato en 1978. Adicionalmente, sugiero que la propuesta estética del libro –los paratextos y el relato enmarcado– funciona como una estrategia para narrar la intimidad que llamo cuasi-cuir de un cuerpo disidente y privado de su libertad ante una esfera pública que lo examina con minucia.
La geometría del agua: una luz pregunta por nosotros
Authors: Meza Barrios Jessica
Published: July 2023

En este artículo[1] presentamos una aproximación al poemario de Fernando Denis (1968), La geometría del agua (2009), basándonos en los presupuestos de la fenomenología de Gaston Bachelard.  En este texto analizaremos el lugar que  ocupa dicha ensoñación en su visión alegórica del mundo y como las isotopías simbólicas como el mar de las imágenes, el jardín, los bosques, los colores, los pájaros místicos, la luz del fuego, los árboles, el cielo y la memoria permitirán transformar la existencia en un sueño. Y esa visión romántica apuntará a  la recuperación de la  identidad del ser, asumiendo una lectura mítica de la vida y la realidad.
Arrayán: la flor de nuestra memoria
Authors: Márquez Cristo Gonzalo
Published: July 2023

Al leer Arrayán de Julio César Goyes que reúne sus libros El eco y la mirada (2001) y El quinde y los geranios (2013), nos queda la certidumbre de que la niñez es el único territorio donde todavía vuela el colibrí. En el primero de sus poemarios el tránsito se inicia en un patio de arrayanes con cuyes, donde una infancia expectante festeja la tierra natal del autor (Ipiales), para luego emprender el descubrimiento de una interiorizada Europa poblada de signos y evocaciones, mientras la indagadora escritura no renuncia a ser deseo y origen, y arrastra en el torrente el linaje de sus palabras de sol y sus silencios de luna.
Lectura crítica de la poesía completa de Rómulo Bustos Aguirre desde
Authors: Romero Guzmán Nelson
Published: July 2023

El presente artículo aborda la obra poética completa de Rómulo Bustos Aguirre. Corresponde a una investigación ensayística de carácter crítico, que se adelanta en la línea de la poesía colombiana del siglo XX. En un principio aglutina a cinco autores, a través de los cuales se muestran las tendencias fundamentales de nuestra lírica en la modernidad. Los instrumentos de análisis crítico de este trabajo son de tipo cualitativo y bibliográfico; la perspectiva de análisis crítico es la hermenéutica simbólica. El objetivo sobre el que recae esta mirada a la poesía de Bustos Aguirre es demostrar los diferentes ciclos por los que ha ido evolucionando su obra: la exaltación de lo sagrado de tono ceremonioso en sus dos primeros libros, y la posterior instauración de una ruptura temática y formal en las siguientes obras. El resultado de este recorrido desemboca en la categoría estética de “lo sublime destruido” de J.P. Ritcher, que vincula la obra de Bustos Aguirre con el humor y el juego en la construcción de un imaginario propio anclado en el mundo Caribe colombiano, con tentáculos en el mito religioso pagano y cristiano.
Nocturnidad y posoccidentalidad en la literatura latinoamericana: Del “Nocturno” de José Asunción Silva a Nocturno de Chile de Roberto Bolaño
Authors: Sedeño-Guillén Kevin
Published: July 2023

El artículo explora desde un enfoque posoccidental la representación de la noche en la narrativa caribeña y latinoamericana contemporánea. Se analiza específicamente la novela Nocturno de Chile (2000), de Roberto Bolaño, en relación con importantes antecedentes como el “Nocturno” (1892), de José Asunción Silva. Esta lectura posoccidental permite establecer conexiones entre Nocturno de Chile y unas fuerzas de discontinuidad ya presentes en el poema de Silva. Bolaño recicla radicalmente la tradición de origen europeo del nocturno hispanoamericano para representar la desarticulación social y cultural de un tiempo dictatorial a la vez subsumido pero desconectado del entorno de Occidente.
¿Cuentos para fomentar el turismo o la ideología de la Generación del Treinta?
Authors: Báez Arroyo María I.
Published: July 2023

En este ensayo se destaca al escritor Emilio S. Belaval, de la llamada Generación del Treinta en Puerto Rico, que ha sido reconocido como uno de nuestros mejores cuentistas.  Esta generación del siglo 20 ha sido muy comentada por sus posiciones ideológicas, las cuales mantuvieron y sostuvieron en muchos ensayos y además, en la narrativa de ese momento.  El objetivo principal de este escrito es destacar qué la caracterización tanto de las feminidades como las masculinidades en el libro Cuentos para fomentar el turismo (1977) de Emilio S. Belaval responden a las concepciones ideológicas de la Generación del Treinta en Puerto Rico.
Jorge Teillier. El poeta de este mundo
Authors: Ordóñez Jorge Eliecer
Published: July 2023

Se trata de un rastreo a la poética de Jorge Teillier, autor chileno que trabaja con vehemencia la llamada Poesía Lárica (de los lares), es decir, la que evidencia la experiencia de la casa y su entorno: la aldea, el territorio primigenio, donde el trabajo, los afectos iniciáticos, el paisaje, la saga familiar, los pioneros, están a la orden del día. Es una poesía que viaja en tren cuando el avión ya ha sobrepasado a la mula.
La física poscuántica: sexualidades alternativas en la ciencia ficción y novum de Vagabunda Bogotá de Luis Carlos Barragán
Authors: Avendaño Cumplido Eduardo
Published: July 2023

Teniendo como eje el concepto de novum de Darko Suvin, y estableciendo una  estrecha relación con la teoría queer, este artículo analiza la novela Vagabunda Bogotá de Luis Carlos Barragán como una propuesta ficcional que permite abordar una visión no binaria del  género, al tiempo que expande imaginariamente el campo de la  sexualidad. Para ello, el artículo ofrece un previo mapeo sobre el estatuto del género de ciencia ficción en Latinoamérica y en el marco de la literatura colombiana donde se inscribe la novela de Barragán.
El otro Borges en Colombia. El viaje olvidado de un poeta universal por cuatro ciudades colombianas en 1965
Authors: García Estrada Rodrigo de J. , López Bermúdez Andrés
Published: July 2023

En julio de 1965 viajó a Colombia el escritor argentino Jorge Luis Borges, quien gozaba de un reconocimiento internacional bien ganado y refrendado por premios, docto-rados honoris causa, y reconocimientos de los Gobiernos de Estados Unidos, Francia, Inglaterra e Italia. En Colombia, pocos intelectuales conocían su obra y se declaraban sus admiradores. Este artículo intenta comprender, desde un contexto político, cultural y diplomático, el viaje y el significado de la presencia del escritor en el país sudamericano, así como formular ciertas reflexiones acerca de su biografía, condicionada por la visión mítica posteriormente instaurada por sus seguidores y fanáticos. A partir de vestigios documentales se reconstruye el paso del otro Borges por Colombia, del humano, del hombre público con sentido de respon-sabilidad social, que cumplió agotadores itinerarios para ofrecer entrevistas y conferencias –a modo de contribución a los intereses de la diplomacia cultural argentina–, periplo que a mediano y largo plazo terminó repercutiendo, además, sobre la divulgación de su obra e imagen.
Rozwijanie mądrości dziecka. Koncepcja i wskazówki metodyczne
Authors: Płóciennik Elżbieta
Published: July 2023

Autorka przedstawia rozwiązania edukacyjne, które od wczesnych etapów życia dziecka pozwolą w optymalny sposób rozwinąć jego zdolności i osobowość, żeby potrafiło sobie radzić z wyzwaniami cywilizacyjnymi XXI w. Czytelnik zapozna się z próbami poszukiwania, weryfikacji i wdrażania innowacyjnych rozwiązań metodycznych, pomocnych w procesie rozwijania refleksyjności, samodzielności działania dzieci, ich kompetencji społecznych i umiejętności rozwiązywania problemów, szczególnie o charakterze twórczym. Znajdzie ponadto propozycje konkretnych ćwiczeń oraz sytuacji edukacyjnych, możliwych do zastosowania w edukacji przedszkolnej i wczesnoszkolnej (choć Czytelnik zapewne dostrzeże ich uniwersalność). Książka z pewnością zainteresuje studentów i nauczycieli akademickich, wychowawców i pedagogów pracujących w różnych instytucjach oświatowych, konsultantów i doradców metodycznych, a także rodziców, którym zależy na efektywnej edukacji dzieci. W kolejnych tomach zostaną przedstawione scenariusze zajęć dla poszczególnych grup wiekowych.
Mądrość, inteligencja i twórczość w nauczaniu. Jak zapewnić uczniom sukces
Authors: Sternberg Robert J. , Jarvin Linda , Grigorenko Elena L.
Published: July 2023

Robert J. Sternberg – klasyk amerykańskiej psychologii, twórca koncepcji edukacji dla mądrości, jeden z najczęściej cytowanych autorów w naukach humanistycznych – wraz ze współautorkami przygotowali podręcznik metodyczny dla nauczycieli wszystkich szczebli edukacyjnych. Przedstawili strategie dydaktyczne mające na celu nie tylko kształtowanie tradycyjnych umiejętności analitycznych u uczniów, lecz także wychowywanie ich na szczęśliwe osoby. Przy każdej prezentacji Czytelnik znajdzie zwięzły wstęp teoretyczny, cele ćwiczeń, zadania dydaktyczne z prostymi instrukcjami, narzędzia do samooceny oraz przykłady lekcji z różnych etapów kształcenia.
Edukacja do samodzielności. Warsztaty z dociekań filozoficznych. Teoria i metodyka
Authors: Pobojewska Aldona
Published: July 2023

Główną zaletą książki jest doskonała precyzja (bez zbędnych, nazbyt formalnych odniesień) w ujmowaniu trudnych zagadnień filozoficznych i wysoki poziom rozważań merytorycznych. Napisana jest przez praktyka, ale głęboko świadomego obszernego zaplecza teoretyczno-konceptualnego, stojącego za konkretnymi rozwiązaniami. To nie tylko wykład określonej metody kształcenia, ale również, a może przede wszystkim – potężna etyka. To nie tylko technika – jak uczyć – ze szczególnym podkreśleniem nauczania – etyki, ale również, a może bardziej podstawowe – przesłanie moralne, które winno towarzyszyć każdemu nauczycielowi. Tym ważniejsze, że nie ograniczone do jednego kontekstu idei (przeświadczeń światopoglądowych), ale przedstawiającego, jak funkcjonować w zróżnicowaniu tych właśnie idei. Z recenzji prof. nadzw. dr. hab. Macieja Woźniczki, Uniwersytet Humanistyczno-Przyrodniczy, im. Jana Długosza w Częstochowie
Logika
Authors: Priest Graham
Published: July 2023

Może się wydawać, że logika nie ma wiele wspólnego z filozofią, a tym bardziej z prawdziwym życiem. Graham Priest pokazuje, jak bardzo ta koncepcja jest błędna. Bada filozoficzne korzenie, pokazuje, jak współczesna logika formalna radzi sobie z takimi zagadnieniami, jak istnienie Boga, rzeczywistość, paradoksy teorii prawdopodobieństwa i decyzji. W przystępny sposób wyjaśnia jej podstawy, pokazując, że logika jest ważną częścią współczesnej filozofii, a także jak może być przydatna w codziennym życiu i komunikacji – pozwala klarownie i skutecznie argumentować. Priest podejmuje również tematy związane z algorytmami i aksjomatami oraz dowodami matematycznymi.
PERANCANGAN TONGKAT BANTU INOVATIF UNTUK TUNANETRA DENGAN MEMANFAATKAN TEKNOLOGI SENSOR GYROSCOPE, GPS DAN ULTRASONIK
Authors: Pambudi Agung , Leonardo Muhammad Diego
Published: July 2023

The eyes are vital human sensory organs that react to light. One of the functions of the eyes is to record the state or surrounding conditions, to know the object.  Then, cones on the retina allow conscious light perception and vision, such as color differentiation and depth perception. The purpose of the research was to develop stick-based technology gyroscope sensors, GPS, and ultrasonic-based microcontrollers. The development of this tool aimed at helping blind people to detect objects around them so that blind people could walk well. The approach in this development utilized the Research and Development (R&D) method, and the testing used the Alpha method. The test results showed that all tools could function properly and could be implemented in the field.

 
Mathematical Models of the UAV Operators
Authors: Szabolcsi Róbert
Published: July 2023

The operators maintaining different kinds of activities might have different mathematical models regarding their physical and mental status, their skills and experiences, their level of training they own. Recent days more and more attention is paid to wide spread of different UAVs applied both in military and in non-military governmental applications. The UAV production industry is able to manufacture UAVs for different and diverging purposes. However, the effective maintenance of these UAVs requires highly trained and qualified operators. When massive UAV applications support combating ground forces in the war theatre the training of the UAV operators becomes to be one of the crucial criteria. Diversity of the UAV types often fabricated and gunned for military purposes shows difficulties of the training program created for UAV operators. This paper addresses mathematical models of the UAV operators applied both in open and closed loop control systems of the UAVs. Additionally, findings of this paper might support and improve selection process of the UAV operators to reach maximum efficiency of both military reconnaissance and combat applications.
Ivan Gavrilovich Alexandrov. Pages of Life and Achievements
Authors: Grigoriev N. D.
Published: July 2023

Academician Ivan Gavrilovich Alexandrov is an outstanding hydropower engineer, the founder of the integrated design of large hydroelectric plants and irrigation systems, the developer of the GOELRO plan, the author of original innovative ideas, which then seriously influenced further development of hydropower engineering and are still of practical importance, the creator of DneproGES. The Angarsk HPP cascade was also designed according to the developments and proposals of Ivan G. Alexandrov. A brilliant researcher, designer, economist, teacher, manager, and administrator graduated from Moscow Engineering School (now Russian University of Transport).

Ivan Alexandrov was recognised worldwide as an outstanding scientist and engineer. His activities mainly fell on the most difficult years of formation of the national economy of the USSR, on the years of the first five-year plans…

For many years he taught at the higher educational institutions of Leningrad and Moscow and enjoyed great love and respect among students.
Analysis of the Relationship between Rail Cant and Track Gauge Based on the Data Obtained by Track Recording Cars
Authors: Gallyamov D. I. , Ovchinnikov D. V.
Published: July 2023

The increase in the service life of track superstructure has always been an important task since this allows reduction in the cost of repairs and current maintenance of the track.

The objective of the work is to determine the mutual influence of the rail cant and the track gauge based on the results of measurements carried out by track recording cars, as well as their impact on the stress-strain state of the rail. The analysis was based on statistical and the finite element methods. Using statistical methods, it was determined that the rail cant and track gauge values do not have a normal distribution and have a weak feedback. The reasons were explained in the conclusions.

To determine with the finite element method contact stresses in the rail head on the track sections available in the sample, with different combinations of rail cant and track gauge, a model with full geometric similarity was developed.

The results obtained from the calculations demonstrate that the deviation of the cant within the range from 1/15 to 1/30 leads to an increase in stresses by more than 20 %, while changing the track gauge has a weak effect on the stress-strain state of the rail head. The maximum increase in contact stresses, at the analysed section, was 97 %, with a cant of 1/990 and a track gauge of 1526 mm.

The growth of contact stresses leads to the formation of fatigue cracks and, as a consequence, to the defects and then to replacement of the rail. To increase the service life of the rails, it is recommended to monitor the condition of fasteners and compliance with the technology of current maintenance works, as well as to reconsider tolerance of the deviation of the cant both upward and downward.
Ensino de Física: uma revisão integrativa sobre o uso de simulações como ferramenta pedagógica
Authors: Leite Girlane Castro Costa , Leite Gilson Carlos Castro Costa
Published: July 2023

No meio educacional, a preocupação dos educadores em melhorar a motivação e o desempenho dos alunos na área de física é uma constante. Neste contexto, a educação por meio do uso de simulações tem conquistado espaço e credibilidade no ensino de física. A viabilidade do uso de simulações como estratégia de ensino na área de física é investigada neste estudo. Utilizou-se o método de pesquisa bibliográfica, com dados coletados nas bases de dados Portal de Periódicos Capes, Eric e Scielo, e análises qualitativas e quantitativas dos resultados obtidos. Os dados evidenciaram que o uso de simulações tem sido uma alternativa metodológica promissora no meio educacional. Considera-se que os resultados deste estudo podem ser úteis aos educadores no desenvolvimento de estratégias de aprendizagem mais efetivas.
DNA methylation profiling in Trisomy 21 females with and without breast cancer
Authors: Bejaoui Yosra , Alresheq Sara , Durand Sophie , Vilaire-Meunier Marie , Maillebouis Louise , Zen Ayman Al Haj , Mégarbané André , Hajj Nady El
Published: July 2023

Background

Down Syndrome (DS) is the most common chromosome anomaly in humans and occurs due to an extra copy of chromosome 21. The malignancy profile in DS is unique, since DS patients have a low risk of developing solid tumors such as breast cancer however they are at higher risk of developing acute myeloid leukemia and acute lymphoblastic leukemia.

Methods

In this study, we investigated DNA methylation signatures and epigenetic aging in DS individuals with and without breast cancer. We analyzed DNA methylation patterns in Trisomy 21 (T21) individuals without breast cancer (T21-BCF) and DS individuals with breast cancer (T21-BC), using the Infinium Methylation EPIC BeadChip array.

Results

Our results revealed several differentially methylated sites and regions in the T21-BC patients that were associated with changes in gene expression. The differentially methylated CpG sites were enriched for processes related to serine-type peptidase activity, epithelial cell development, GTPase activity, bicellular tight junction, Ras protein signal transduction, etc. On the other hand, the epigenetic age acceleration analysis showed no difference between T21-BC and T21-BCF patients.

Conclusions

This is the first study to investigate DNA methylation changes in Down syndrome women with and without breast cancer and it could help shed light on factors that protect against breast cancer in DS.
The role of green finance in reducing agricultural non-point source pollution—an empirical analysis from China
Authors: Lv Wen , Zhang Zheng , Zhang Xiaran
Published: July 2023

Introduction

Green finance plays a crucial role in driving sustainable development and has the potential to effectively reduce pollution emissions, thereby positively impacting the environment. However, in the agricultural sector, China, unlike developed countries, primarily relies on a small-peasant economy, and the green financial system is not well-developed. As a result, the specific emission reduction effects and mechanisms of green finance on agricultural non-point source pollution (ANSP) remain unclear. The objective of our research is to explore the internal mechanisms through which green finance influences ANSP, with the aim of providing valuable policy insights to the government and promoting the green transformation of agriculture for enhanced food security.

Methods

This study employs an empirical analysis of green finance on ANSP using provincial panel data from China spanning the years 2005 to 2020. By utilizing robust data and applying empirical analysis, we can derive scientifically credible conclusions. We introduce a relative indicator to assess the trend of ANSP and investigate the pathways through which green finance operates using heterogeneity analysis, intermediary effect evaluation, and threshold effect analysis.

Results and Discussion

The empirical findings reveal the following insights: (1) While green finance demonstrates a significant reduction effect on ANSP, this effect varies across different regions. Specifically, the impact of green finance on ANSP reduction is more pronounced in areas characterized by strong comprehensive agricultural strength, high levels of economic development, and predominantly focused on plantation agriculture. (2) From a mechanistic standpoint, green finance substantially diminishes ANSP by facilitating agricultural scaling and promoting the adoption of green technologies. (3) The threshold effect analysis demonstrates that the mitigation effect of green finance on ANSP exhibits non-linear characteristics, with a double threshold effect observed. As the level of green finance development increases, the mitigation effect is further enhanced.

Conclusion

In conclusion, the appropriate implementation of green finance can effectively enhance the agricultural environment and ensure food security. Considering the heterogeneity of the role of green finance and the presence of threshold values, it is crucial for the government to tailor green finance policies according to local conditions. This research not only expands on previous studies but also offers valuable insights for the government in formulating green finance policies. Furthermore, it provides a viable pathway for reducing ANSP while serving as a reference for other developing countries aiming to establish green agriculture and sustain food system security.
L'approche axée sur le cycle de vie dans la Convention de Minamata sur le mercure : une question de mise en oeuvre ?
Authors: Thirion Sophie
Published: July 2023

La Convention de Minamata sur le mercure est entrée en vigueur le 16 août 20171. La première réunion de la Conférence des parties (COP-1) s’est tenue en novembre 2017 et a été l’occasion d’adopter vingt et une décisions, point de départ du vaste chantier de mise en oeuvre qui s’est ouvert à l’occasion de l’entrée en vigueur du traité. Ce dernier régule le mercure en fonction des stades d’utilisation de la substance par l’homme, et ambitionne d’en finir avec certaines utilisations à des dates déterminées2. Pour d’autres usages du mercure, des réglementations moins contraignantes s’appliquent, prenant en compte les difficultés socio-économiques de certains États à transformer leurs modes de production vers des activités sans mercure. Saluée par la doctrine comme un instrument offrant un cadre de gestion du mercure tout au long de son cycle de vie, la Convention de Minamata fait preuve d’une souplesse à même de nuancer cette affirmation.
TRICUSPID VALVE REPAIR – OUR EARLY EXPERIENCE WITH EDWARDS C-E PHYSIO TRICUSPID ANNULOPLASTY RINGS
Authors: Faisal Mufti , Kesharwani Peeyush , Padhy Ajit , Popli Khushwant , Gupta Anubhav , Hadiya Nootan
Published: July 2023

Objectives: Very few studies can be found in the current literature regarding post-operative outcome of contoured
tricuspid annuloplasty rings. The aim of our study was to analyse our early results of tricuspid annuloplasty using
contoured annuloplasty rings and to compare Medtronic Contour 3D ring with Edwards C-E Physio Tricuspid ring. A Material and Methods:
retrospective analysis of our hospital records was done to analyze the outcome of patients who had undergone tricuspid valve repair using
contoured annuloplasty rings between June 2021 and January 2022. Post-operative transthoracic echocardiography was done to assess any
residual tricuspid regurgitation and patients were clinically assessed using NYHA functional classication. Average duration of follow-up for all
patients was 5.6 ± 2 months (3-10). We identied 50 patients for the study among whi Results: ch 25 patients had Contour 3D ring implant and 25
patients had Physio Tricuspid ring implant. Average age of the patients was 32.6 ± 12 years. There was signicant improvement in NYHA
functional class, grade of tricuspid regurgitation and PASP in both groups. However, comparison between Physio Tricuspid ring and Contour 3D
ring did not reach any clinical signicance. Edwards C-E Physio Tricuspid annulopla Conclusion: sty ring has shown promising early results in
our study with low rates of recurrent tricuspid regurgitation and signicant clinical improvement. The results are comparable with Medtronic
Contour 3D ring with no signicant difference between the two types of rings. However, the sample size being small and follow-up being short,
larger and long-term studies shall follow to conrm the ndings of the present study.