bluuebunny/crossref_metadata_2025 huggingface dataset:
Ucuùba (Virola surinamensis) Fat-Based Nanostructured Lipid Carriers for Nail Drug Delivery of Ketoconazole: Development and Optimization Using Box-Behnken Design
Authors: Pereira Rayanne R. , Testi Matteo , Rossi Francesca , Silva Junior Jose O. C. , Ribeiro-Costa Roseane M. , Bettini Ruggero , Santi Patrizia , Padula Cristina , Sonvico Fabio
Published: June 2019

Ucuùba fat is fat obtained from a plant found in South America, mainly in Amazonian Brazil. Due to its biocompatibility and bioactivity, Ucuùba fat was used for the production of ketoconazole-loaded nanostructured lipid carriers (NLC) in view of an application for the treatment of onychomycosis and other persistent fungal infections. The development and optimization of Ucuùba fat-based NLC were performed using a Box-Behnken design of experiments. The independent variables were surfactant concentration (% w/v), liquid lipids concentration (% w/v), solid lipids concentration (% w/v), while the outputs of interest were particle size, polydispersity index (PDI) and drug encapsulation efficiency (EE). Ucuùba fat-based NLC were produced and the process was optimized by the development of a predictive mathematical model. Applying the model, two formulations with pre-determined particle size, i.e., 30 and 85 nm, were produced for further evaluation. The optimized formulations were characterized and showed particle size in agreement to the predicted value, i.e., 33.6 nm and 74.6 nm, respectively. The optimized formulations were also characterized using multiple techniques in order to investigate the solid state of drug and excipients (DSC and XRD), particle morphology (TEM), drug release and interactions between the formulation components (FTIR). Furthermore, particle size, surface charge and drug loading efficiency of the formulations were studied during a one-month stability study and did not show evidence of significant modification.
Paclitaxel-Loaded Silk Fibroin Nanoparticles: Method Validation by UHPLC-MS/MS to Assess an Exogenous Approach to Load Cytotoxic Drugs
Authors: Perteghella Sara , Sottani Cristina , Coccè Valentina , Negri Sara , Cavicchini Loredana , Alessandri Giulio , Cottica Danilo , Torre Maria Luisa , Grignani Elena , Pessina Augusto
Published: June 2019

The aim of this work was to load an anticancer drug, paclitaxel (PTX), on Silk Fibroin Nanoparticles (SFNs) by using an exogenous approach. SFNs were produced, freeze-dried and then loaded with PTX. An exogenous method allowed us to reduce both drug loss and environmental impact. In order to quantify PTX loaded in SFNs, a simple and reliable method using reversed phase liquid chromatography coupled to tandem mass spectrometry (rp-UHPLC-MS/MS) was developed. This methodology was validated by the determination of spiked QC samples in three consecutive days. Good accuracy and precision of the method were obtained, while the intra-day and inter-day precisions were less than 10.3%. For PTX, the limit of quantitation (LOQ) was 5.0 ng/mL. Recovery from the matrix (SFNs-PTX pellets) was calculated (81.2% at LOQ value) as PTX was entrapped in a new matrix like the polymer silk fibroin-based. This method was successfully applied to determine the encapsulation efficiency (1.00 ± 0.19%) and the nanoparticle loading (0.12 ± 0.02% w/w). The in vitro anticancer activity of SFNs-PTX was tested against CFPAC-1 cancer cells; results demonstrated a very high cytotoxic activity of SFNs-PTX, with a dose dependent inhibition of CFPAC-1 proliferation, confirmed by the IC50 value of 3450 ± 750 ng/mL.
Differential Inter-System Biases Estimation and Initial Assessment of Instantaneous Tightly Combined RTK with BDS-3, GPS, and Galileo
Authors: Wu Mingkui , Liu Wanke , Wang Wang , Zhang Xiaohong
Published: June 2019

In this contribution, we assess, for the first time, the tightly combined real-time kinematic (RTK) with GPS, Galileo, and BDS-3 operational satellites using observations from their overlapping L1-E1-B1C/L5-E5a-B2a frequencies. First, the characteristics of B1C/B2a signals from BDS-3 operational satellites is evaluated compared to GPS/Galileo L1-E1/L5-E5a signals in terms of observed carrier-to-noise density ratio, pseudorange multipath and noise, as well as double-differenced carrier phase and code residuals using data collected with scientific geodetic iGMAS and commercial M300Pro receivers. It’s demonstrated that the observational quality of B1C/B2a signals from BDS-3 operational satellites is comparable to that of GPS/Galileo L1-E1/L5-E5a signals. Then, we investigate the size and stability of phase and code differential inter-system bias (ISB) between BDS-3/GPS/Galileo B1C-L1-E1/B2a-L5-E5a signals using short baseline data collected with both identical and different receiver types. It is verified that the BDS-3/GPS/Galileo ISBs are indeed close to zero when identical type of receivers are used at both ends of a baseline. Moreover, they are generally present and stable in the time domain for baselines with different receiver types, which can be easily calibrated and corrected in advance. Finally, we present initial assessment of single-epoch tightly combined BDS-3/GPS/Galileo RTK with single-frequency and dual-frequency observations using a formal and empirical analysis, consisting of ambiguity dilution of precision (ADOP), ratio values, the empirical ambiguity resolution success rate, and the positioning accuracy. Experimental results demonstrate that the tightly combined model can deliver much lower ADOP and higher ratio values with respect to the classical loosely combined model whether for GPS/BDS-3 or GPS/Galileo/BDS-3 solutions. The positioning accuracy and the empirical ambiguity resolution success rate are remarkably improved as well, which could reach up to approximately 10%∼60% under poor observational conditions.
Performance Evaluation of Newly Proposed Seaweed Enhancing Index (SEI)
Authors: Siddiqui Muhammad , Zaidi Arjumand , Abdullah Muhammad
Published: June 2019

Seaweed is a valuable coastal resource for its use in food, cosmetics, and other items. This study proposed new remote sensing based seaweed enhancing index (SEI) using spectral bands of near-infrared (NIR) and shortwave-infrared (SWIR) of Landsat 8 satellite data. Nine Landsat 8 satellite images of years 2014, 2016, and 2018 for the January, February, and March months were utilized to test the performance of SEI. The seaweed patches in the coastal waters of Karachi, Pakistan were mapped using the SEI, normalized difference vegetation index (NDVI), and floating algae index (FAI). Seaweed locations recorded during a field survey on February 26, 2014, were used to determine threshold values for all three indices. The accuracy of SEI was compared with NDVI while placing FAI as the reference index. The accuracy of NDVI and SEI were assessed by matching their spatial extent of seaweed cover with FAI enhanced seaweed area. SEI images of January 2016, February 2018, and March 2018 enhanced less than 50 percent of the corresponding FAI total seaweed areas. However, on these dates the NDVI performed very well, matching more than 95 percent of FAI seaweed coverage. Except for these three times, the performance of SEI in the remaining six images was either similar to NDVI or even better than NDVI. SEI enhanced 99 percent of FAI seaweed cover on January 2018 image. Overall, seaweed area not covered by FAI was greater in SEI than NDVI in almost all images, which needs to be further explored in future studies by collecting extensive field information to validate SEI mapped additional area beyond the extent of FAI seaweed cover. Based on these results, in the majority of the satellite temporal images selected for this study, the performance of the newly proposed index—SEI, was found either better than or similar to NDVI.
Comparative Study on Variable Selection Approaches in Establishment of Remote Sensing Model for Forest Biomass Estimation
Authors: Yu Xiaohui , Ge Hongli , Lu Dengsheng , Zhang Maozhen , Lai Zhouxiang , Yao Rentu
Published: June 2019

In the field of quantitative remote sensing of forest biomass, a prominent phenomenon is the increasing number of explanatory variables. Then how to effectively select explanatory variables has become an important issue. Linear regression model is one of the commonly used remote sensing models. In the process of establishing the linear regression model, a vital step is to select explanatory variables. Focusing on variable selection and model stability, this paper conducts a comparative study on the performance of eight linear regression parameter estimation methods (Stepwise Regression Method (SR), Criterions Based on The Bayes Method (BIC), Criterions Based on The Bayes Method (AIC), Criterions Based on Prediction Error (Cp), Least Absolute Shrinkage and Selection Operator (Lasso), Adaptive Lasso, Smoothly Clipped Absolute Deviation (SCAD), Non-negative garrote (NNG)) in the subtropical forest biomass remote sensing model development. For the purpose of comparison, OLS and RR, are commonly used as methods with no variable selection ability, and are also compared and discussed. The performance of five aspects are evaluated in this paper: (i) Determination coefficient, prediction error, model error, etc., (ii) significance test about the difference between determination coefficients, (iii) parameter stability, (iv) variable selection stability and (v) variable selection ability of the methods. All the results are obtained through a five ten-fold CV. Some evaluation indexes are calculated with or without degrees of freedom. The results show that BIC performs best in comprehensive evaluation, while NNG, Cp and AIC perform poorly as a whole. Other methods show a great difference in the performance on each index. SR has a strong capability in variable selection, although it is poor in commonly used indexes. The short-wave infrared band and the texture features derived from it are selected most frequently by various methods, indicating that these variables play an important role in forest biomass estimation. Some of the conclusions in this paper are likely to change as the study object changes. The ultimate goal of this paper is to introduce various model establishment methods with variable selection capability, so that we can have more choices when establishing similar models, and we can know how to select the most appropriate and effective method for specific problems.
A Glove-Based Form Factor for Collecting Joint Acoustic Emissions: Design and Validation
Authors: Bolus Nicholas B. , Jeong Hyeon Ki , Whittingslow Daniel C. , Inan Omer T.
Published: June 2019

Sounds produced by the articulation of joints have been shown to contain information characteristic of underlying joint health, morphology, and loading. In this work, we explore the use of a novel form factor for non-invasively acquiring acoustic/vibrational signals from the knee joint: an instrumented glove with a fingertip-mounted accelerometer. We validated the glove-based approach by comparing it to conventional mounting techniques (tape and foam microphone pads) in an experimental framework previously shown to reliably alter healthy knee joint sounds (vertical leg press). Measurements from healthy subjects (N = 11) in this proof-of-concept study demonstrated a highly consistent, monotonic, and significant (p < 0.01) increase in low-frequency signal root-mean-squared (RMS) amplitude—a straightforward metric relating to joint grinding loudness—with increasing vertical load across all three techniques. This finding suggests that a glove-based approach is a suitable alternative for collecting joint sounds that eliminates the need for consumables like tape and the interface noise associated with them.
Interferometric SAR Phase Denoising Using Proximity-Based K-SVD Technique
Authors: Ojha Chandrakanta , Fusco Adele , Pinto Innocenzo M.
Published: June 2019

This paper addresses the problem of interferometric noise reduction in Synthetic Aperture Radar (SAR) interferometry based on sparse and redundant representations over a trained dictionary. The idea is to use a Proximity-based K-SVD (ProK-SVD) algorithm on interferometric data for obtaining a suitable dictionary, in order to extract the phase image content effectively. We implemented this strategy on both simulated as well as real interferometric data for the validation of our approach. For synthetic data, three different training dictionaries have been compared, namely, a dictionary extracted from the data, a dictionary obtained by a uniform random distribution in [ − π , π ] , and a dictionary built from discrete cosine transform. Further, a similar strategy plan has been applied to real interferograms. We used interferometric data of various SAR sensors, including low resolution C-band ERS/ENVISAT, medium L-band ALOS, and high resolution X-band COSMO-SkyMed, all over an area of Mt. Etna, Italy. Both on simulated and real interferometric phase images, the proposed approach shows significant noise reduction within the fringe pattern, without any considerable loss of useful information.
Dynamic Responses of Electrically Driven Quartz Tuning Fork and qPlus Sensor: A Comprehensive Electromechanical Model for Quartz Tuning Fork
Authors: Lee Manhee , Kim Bongsu , An Sangmin , Jhe Wonho
Published: June 2019

A quartz tuning fork and its qPlus configuration show different characteristics in their dynamic features, including peak amplitude, resonance frequency, and quality factor. Here, we present an electromechanical model that comprehensively describes the dynamic responses of an electrically driven tuning fork and its qPlus configuration. Based on the model, we theoretically derive and experimentally validate how the peak amplitude, resonance frequency, quality factor, and normalized capacitance are changed when transforming a tuning fork to its qPlus configuration. Furthermore, we introduce two experimentally measurable parameters that are intrinsic for a given tuning fork and not changed by the qPlus configuration. The present model and analysis allow quantitative prediction of the dynamic characteristics in tuning fork and qPlus, and thus could be useful to optimize the sensors’ performance.
A Distance-Vector-Based Multi-Path Routing Scheme for Static-Node-Assisted Vehicular Networks
Authors: Araki Daichi , Yoshihiro Takuya
Published: June 2019

Vehicular Ad hoc NETworks (VANET) has been well studied for a long time as a means to exchange information among moving vehicles. As vehicular networks do not always have connected paths, vehicular networks can be regarded as a kind of delay-tolerant networks (DTNs) when the density of vehicles is not high enough. In this case, packet delivery ratio degrades significantly so that reliability of networks as an information infrastructure is hardly held. Past studies such as SADV (Static-node Assisted Data dissemination protocol for Vehicular networks) and RDV (Reliable Distance-Vector routing) showed that the assistance of low-cost unwired static nodes located at intersections, which work as routers to provide distance-vector or link-state routing functions, significantly improves the communication performance. However, they still have problems: SADV does not provide high-enough delivery ratio and RDV suffers from traffic concentration on the shortest paths. In this paper, we propose MP-RDV (Multi-Path RDV) by extending RDV with multiple paths utilization to improve performance against both of those problems. In addition, we apply a delay routing metric, which is one of the major metrics in this field, to RDV to compare performance with the traffic-volume metric, which is a built-in metric of RDV. Evaluation results show that MP-RDV achieves high load-balancing performance, larger network capacity, lower delivery delay, and higher fault tolerance against topology changes compared to RDV. As for routing metrics, we showed that the traffic-volume metric is better than the delay one in RDV because delay measurement is less stable against traffic fluctuation.
Self-Triggered Formation Control of Nonholonomic Robots
Authors: Santos Carlos , Espinosa Felipe , Martinez-Rey Miguel , Gualda David , Losada Cristina
Published: June 2019

In this paper, we report the design of an aperiodic remote formation controller applied to nonholonomic robots tracking nonlinear, trajectories using an external positioning sensor network. Our main objective is to reduce wireless communication with external sensors and robots while guaranteeing formation stability. Unlike most previous work in the field of aperiodic control, we design a self-triggered controller that only updates the control signal according to the variation of a Lyapunov function, without taking the measurement error into account. The controller is responsible for scheduling measurement requests to the sensor network and for computing and sending control signals to the robots. We design two triggering mechanisms: centralized, taking into account the formation state and decentralized, considering the individual state of each unit. We present a statistical analysis of simulation results, showing that our control solution significantly reduces the need for communication in comparison with periodic implementations, while preserving the desired tracking performance. To validate the proposal, we also perform experimental tests with robots remotely controlled by a mini PC through an IEEE 802.11g wireless network, in which robots pose is detected by a set of camera sensors connected to the same wireless network.
A Low-Cost Chamber Prototype for Automatic Thermal Analysis of MEMS IMU Sensors in Tilt Measurements Perspective
Authors: Ruzza Giuseppe , Guerriero Luigi , Revellino Paola , Guadagno Francesco M.
Published: June 2019

In this work, a low-cost, open-source and replicable system prototype for thermal analysis of low-cost Micro Electro-Mechanical Systems (MEMS) Inertial Measurement Unit (IMU) sensors in tilt measurement perspective is presented and tested. The system is formed of a 3D printed frame, a thermal cell consisting in a Peltier element mounted over a heat sink, and a control and power system. The frame is designed to allow the independent biaxial tilting of the thermal cell through two servomotors. The control board is formed by an Arduino® and a self-made board including a power drive for controlling the thermal unit and servomotors. We tested the chamber analyzing the behavior of multiple MEMS IMU onboard accelerometers suitable for measuring tilt. Our results underline the variability of the thermal behavior of the sensors, also for different sensor boards of the same model, and consequently the need for the adoption of a thermal compensation strategy based on thermal analysis results. These data suggesting the need for the analysis of the thermal behavior of MEMS-based sensors, indicate the potential of our system in making low-cost sensors suitable in medium-to-high precision monitoring applications.
Continuous intracranial pressure monitoring in severe traumatic brain injury in children
Authors: Iencean St. M. , Tascu A. , Apetrei C. A. , Gheorghita C. , Lo Tsz-Yan Milly , Piper Ian , Iencean A. St.
Published: June 2019

We present the results of the Romanian team for the multi-center grant “Paediatric Brain Monitoring with Information Technology (KidsBrainIT). Using IT Innovations to Improve Childhood Traumatic Brain Injury Intensive Care Management, Outcome, and Patient Safety”, acronym KidsBrainIT. Children aged 2 to 16 years who require intensive care management after sustaining traumatic severe brain injury are included in this study in three neurosurgical hospital: "Prof. Dr. N. Oblu" Clinical Emergency Hospital Iasi, "Sf. Maria" Children Clinical Emergency Hospital Iasi and "Bagdasar-Arseni" Clinical Emergency Hospital Bucharest. Continuous real-time intracranial pressure monitoring became a "gold standard" in TBI intensive-care management and ICP-lowering therapy is recommended when ICP is elevated above 20 mmHg or more. Continuous ICP and mean arterial blood pressure (MAP) monitoring allow calculation of cerebral perfusion pressure (CPP) and to establish of an optimal CPP. This study aims to improve the treatments and the outcomes in severe traumatic brain injury in children.
Cerebral pilocytic astrocytoma with spontaneous intratumoral haemorrhage in the elderly - a rare entity
Authors: Narang Amit , Aggarwal Varun , Kavita Divya , Maheshwari Chandni , Bansal Prajjwal
Published: June 2019

Pilocytic astrocytomas (PA) are histologically are low-grade tumours, commonly found in the paediatric and young adult population. Although cases of adult and elderly pilocytic astrocytomas are described in the literature, they are quite uncommon. The rate of PAs with spontaneous bleeding is very less, with a high occurrence in children than in adults, moreover, that is in cerebellar PAs. Cerebral PAs with intratumoral haemorrhage in the older age group is extremely rare. We present a case of a 60-year female presenting with acute neurological compromise resulting from an acutely haemorrhagic Left temporal pilocytic astrocytoma. She was managed surgically with evacuation of tumoral haemorrhages, as well as resection of the tumour. Postoperatively the patient made a remarkable recovery.
(De)Legitimasi Hukuman Pidana Mati: Sebuah Pertimbangan Etis
Authors: Zaluchu Sonny Eli , Gulo Eirene Kardiani
Published: June 2019

The death penalty is always in controversy. Ethical considerations in terms of ethics, principle, and criminality always produce two strong opinions, which are the pros and cons. The two opposing views have strong arguments and considerations concerning the maximum punishment for particular crimes. Countries in the world divided into two acts. Some chose the moratorium option, but there were also those who continued to defend it. This article describes that there are indeed substantive difficulties in an attempt to legitimize or delegitimize the death penalty. These difficulties are presented and analyzed in this paper by using theological approaches, especially in a legal perspective, the right to human life and biblical orders not to kill. The descriptive analysis was carried out by utilizing a literature review and research results.AbstrakHukuman mati selalu di dalam kontroversi. Pertimbangan moral dalam hal etika, azasi dan pidana selalu menghasilkan dua kubu pendapat yang sama-sama kuat yakni yang pro dan kontra. Kedua pandangan yang saling bertolak belakang tersebut memiliki argumentasi dan pertimbangan yang kuat menyangkut hukuman maksimal terhadap kejahatan istimewa. Negara-negara di dunia terbagi dua. Ada yang memilih opsi moratorium tetapi ada juga yang terus mempertahankannya. Artikel ini memaparkan secara deskriptif bahwa memang terdapat kesulitan-kesulitan substantif dalam setiap usaha legitimasi dan atau delegitimasi terhadap hukuman mati. Kesulitan-kesulitan tersebut dipaparkan dan dianalisis di dalam paper ini dengan menggunakan pendekatan teologis khususnya dalam persepektif hukum, hak hidup manusia dan perintah Alkitab untuk jangan membunuh. Analisis dilakukan secara dengan memanfaatkan tinjauan literatur dan hasil-hasil penelitian.
Perancangan Sistem Informasi Pembayaran Elektornik Pada Kantin XYZ
Authors: Nurhayati Sri
Published: June 2019

Tujuan dari penelitian ini adalah menghasilkan analisis dan rancangan dari sistem informasi pembayaran elektronik (e-payment). Perkembangan teknologi informasi  yang sangat cepat menjadi salah satu pertimbangan untuk memberikan kemudahan dalam pemenuhan kebutuhan sehari – hari,  salah satu contohnya adalah dalam sistem pembayaran. Sistem pembayaran merupakan sebuah mekanisme yang digunakan untuk memindahkan sejumlah dana dari satu pihak ke pihak lain secara efisien. Salah satu contoh penerapan teknologi informasi dalam sistem pembayaran adalah e-Payment.  Sistem ini merupakan alternatif sistem pembayaran yang lebih aman, cepat dan praktis dibandikan sistem pembayaran tradisional. Seperti halnya saat ini di kantin Perguruan Tinggi XYZ, sistem pembayaran yang dilakukan masih bersifat tradisional yaitu menggunakan pembayaran tunai.  Hal tersebut tentunya tidak efisien karena harus menyediakan uang kembalian.  Dari sistem tersebut juga menimbulkan ketidaknyamanan dalam  bertransaksi yaitu akan terjadi antrian dalam bertransaksi, misalnya disetiap transaksi akan ada waktu yang tersita untuk menghitung uang pembayaran, menghitung kembalian,  dan memastikan uang yang diterma adalah uang asli [1].  Model yang digunakan untuk pengembangan  perangkat lunak pada penelitian ini menggunakan model waterfall. Metode analisis yang digunakan untuk pembuatan system ini adalah dengan pendekatan berbasis objek. Hasil dari penelitian ini sudah didapatkan rekomendasi analisisi dan rancangan sistem pembayaran elektronik untuk  kantin  XYZ yang akan memberikan kemudahan, kenyamanan dan efisien dalam  bertransaksi.
Luke Cage: A representação da luta de uma comunidade sitiada
Authors: Soares Orson , Silveira Rosana Vaz , Pinheiro Cristiano Max Pereira
Published: June 2019

Neste artigo aborda-se a representação do personagem Luke Cage, inspirado nos quadrinhos da Marvel e adaptado pela empresa Netflix. Objetiva-se observar a questão racial, considerando a história e o contexto de alguns personagens, como também se apresenta uma reflexão sobre a emancipação política da comunidade negra no Harlem. Nesse sentido, a pesquisa trata da análise das características do herói na trama e suas representações no espaço de uma comunidade sitiada, observado nos primeiros onze episódios. Para tanto, a pesquisa bibliográfica baseia-se no conceito de representação (HALL, 2000; FERRO, 1975), de racismo e emancipação política (FANON, 2010), como também, sobre o gueto (WACQUANT, 2008). Esta abordagem proporcionou uma análise sobre personagens que simbolizam o processo de emancipação de um povo submetido às vicissitudes de uma sociedade racista.
Apresentação do Dossiê
Authors: Caravela Gabriela Borges Martins , Aguaded Ignacio
Published: June 2019

Este dossiê organizado para a revista Lumina é fruto da parceria institucional no âmbito da Rede Interinstitucional Euroamerica de Investigação sobre Competências Midiáticas para a cidadania e nasce das discussões suscitadas nos projetos Competência midiática em cenários brasileiros e euroamericanos, financiado pelo CNPq e Fapemig e liderado pela UFJF e Competencias mediáticas de la ciudadanía en medios digitales emergentes (smartphones y tablets): practicas innovadoras y estrategias educomunicativas en contextos múltiples, financiado pelo Fondo Europeo de Desarrollo Regional (FEDER) y Ministerio de Economía y Competitividad de España, liderado pelas Universidades de Huelva, Valladolid e Pompeu Fabra.
O papel das vítimas nas narrativas jornalísticas sobre o desastre em Mariana
Authors: Amaral Márcia Franz , Motta Juliana
Published: June 2019

Nosso objetivo é analisar como as narrativas dos telejornais configuraram as manifestações das vítimas do desastre em Mariana (MG) nas primeiras 24 horas de cobertura da Rede Globo de Televisão. A intenção do trabalho é refletir sobre como o jornalismo transpõe um problema individual para o âmbito de problema público a partir dos aportes teóricos de Queré (2011), Lage (2013; 2016) e Charaudeau (2007; 2010). Entre as 27 inserções veiculadas sobre o rompimento da barragem de rejeitos, analisamos as cinco reportagens que apresentaram um total de 11 depoimentos de vítimas. Sistematizamos quais tiveram visibilidade de acordo com o grau de proximidade com o acontecimento. Também observamos como o jornalismo evocou suas falas e que efeitos patêmicos foram mobilizados a partir destes depoimentos. Concluímos que as narrativas jornalísticas se utilizam das manifestações das vítimas com efeitos patêmicos mais ligados à aflição, terror e tristeza. A maior parte das vítimas sequer é identificada pelas reportagens e suas manifestações são da ordem do sofrimento, sendo silenciadas menções às causas, riscos e vulnerabilidades do desastre ou a qualquer tipo de indignação pelo ocorrido.
Flujos y reflujos en el desarrollo del budismo asiático: un recorrido por la historia del movimiento de meditación vipassana.
Authors: Carini Catón Eduardo
Published: June 2019

El presente artículo se centra en indagar en la historia de la organización budista internacional Vipassana Meditation. Primero, realiza un recorrido por el desarrollo del budismo en Asia, haciendo hincapié en su afincamiento en Birmania. Luego, explora las trayectorias vitales de los líderes religiosos que formaron la mencionada organización y analiza los principales rasgos de la cosmovisión vipassana. Finalmente, reflexiona sobre la forma en que el budismo se desarrolla mediante un proceso de flujo de ideas y prácticas que van y vienen entre la India, el Sudeste Asiático y Occidente.
REFORMA PROTESTANTE, VOCAÇÃO PASTORAL E “BLINDAGEM” DO PODER NA ATUALIDADE PENTECOSTAL
Authors: Washington James
Published: June 2019

O objeto de estudo do artigo em questão é a analise da ideia de unção no Antigo Testamento (AT) e no Novo Testamento (NT), levando em consideração que este ato na verdade sanciona uma série de atividades religiosas encaradas como “ministérios”, envolvendo assim pontos importantes da chamada História Antiga, ligada especificamente ao povo Judeu e as demais nações hoje situadas na África e na Europa. Contudo é conveniente observarmos que a questão da unção é culturalmente ligada a uma vontade divina direcionada aos homens, por isso, a análise destes elementos necessita de um recorte temporal e de uma análise das sagradas escrituras ligadas ao Judaísmo e ao Cristianismo (Bíblia). O recorrente uso destes textos é parte do nosso método de reconstrução estrutural do conceito de unção e do seu poder simbólico, tendo como inspiração ás análises de Pierre Bourdieu, o que implica numa ideia intrínseca de campo e de suas disposições duráveis de manutenção que são os hábitos. Desta maneira, o que é tecido aqui é uma crítica ao que chamamos de blindagem da dominação carismática efetuada pelos líderes pentecostais na Assembleia de Deus, uma vez que “ungidos pelo senhor”, estariam eclesialmente e socialmente blindados contra qualquer elemento contraditório ou crítica as suas formas de ação eclesial. Palavras-Chave: Vocação. Dominação. Blindagem.
PROTESTANTISMO, GÊNERO, PODER: a rejeição da ordenação feminina entre os batistas mineiros
Authors: Leal Jair Souza
Published: June 2019

Em 2014 a seção mineira da Ordem dos Pastores Batistas do Brasil votou não aceitar a ordenação feminina. Nos últimos anos diversas mulheres foram ordenadas pastoras, vindo a fazer parte da Ordem nacional, inclusive da sua diretoria estatutária. Mas estas não são aceitas nas seções estaduais. A questão gerou conflitos e levou a Ordem nacional a orientar às seções estaduais a deliberarem sobre o assunto. Algumas seções estaduais votaram favoráveis, outras, como a mineira, não. Todas justificaram a decisão em textos bíblicos. Buscando compreender o tema, a partir da pesquisa do cientista da religião João Pedro Gonçalves Araújo, recorremos a elementos que forjaram o pensamento batista brasileiro, e que estão presentes na cultura norte-americana e na sociedade burguesa europeia.
William of St. Amour's De periculis novissimorum temporum: A False Start to Medieval Antifraternalism?
Authors: Geltner Guy
Published: June 2019

In the 1250s, William of St. Amour led an audacious assault on the mendicant orders which would resonate down the centuries, despite the utter failure of his own campaign. Yet the relations between his magnum opus, De periculis novissimorum temporum (On the Dangers of the Last Times, written in 1256), and his putative followers require fuller elucidation. What sets William apart from the vast majority of the friars’ pre-Reformation critics are the objectives of his disparagement rather than his rhetoric. For William denied the orthodoxy of religious mendicancy tout court– a position that was rare prior to the religious revolutions of the early sixteenth century.
PERSEPSI AKUNTAN DAN MAHASISWA AKUNTANSI TERHADAP KEMAMPUAN YANG HARUS DIMILIKI OLEH SEORANG FORENSIC ACCOUNTANT
Authors: Sukanto Eman , Widaryanti Widaryanti
Published: June 2019

This study aims to analyze differences in perceptions of Government Auditors, Public Accountants, Corporate Internal Auditors, Corporate Accountants, Accounting Lecturers and Senior Accounting Students for the capabilities that must be possessed by Forensic Accountants. The object of this research is the professional group of Government Auditors, internal government Auditors, Public Accountants, Corporate Internal Auditors, Corporate Accountants, Accounting Lecturers and Senior Accounting Students in the Jakarta and Central Java regions. This study uses a purposive sampling technique in data collection. Data was obtained by distributing questionnaires to each group. A total of 156 questionnaires were collected. Government auditor samples were distributed to Central BPK employees and inspectors in Central Java, Public Accountants, Internal Auditors, Corporate Accountants in several large companies in Jakarta and Central Java. While the questionnaire for lecturers and senior students was distributed to PTN and PTS in Jakarta and Central Java. Data analysis was carried out with One Way Analysis of Variance (Annova). The results showed that there is no difference in perception between government auditors and internal government, public accountants, corporate accountants, company internal auditors, accounting lecturers and accounting students about the capabilities that must be possessed by forensic accountants. There are differences in perceptions between government internal auditors, public accountants, corporate internal audits and accounting lecturers with senior accounting students about the capabilities that must be possessed by forensic accountants. There is no difference in perception between government auditors and company accountants with senior accounting students about the capabilities that must be possessed by forensic accountants. In addition, overall respondents gave a high assessment of the knowledge, traits, skills and abilities that Forensic Accountants must possess. This shows that the respondent agrees that a forensic accountant needs to have high abilities according to the AICPA FVS Section criteria.
The Effect Of Implementation Of Learning Method Of Team Based Learning On Motivation And Learning Outcomes Of Nursing Diploma Study Program In Health Academy Of Karya Husada Yogyakarta
Authors: Yunitasari Pritta , Kusumawati Wiwik , Afandi Moh
Published: June 2019

Learning motivation is an important thing owned by a Nursing student because it directly affects the student’s learning outcomes. The learning method of team based learning is student center learning strategy to improve the student’s motivation and learning outcomes. The research objective is to get to know the effect of implementation of learning method of team based learning on students’ motivation and learning outcomes compared to lecturing method. The research type is quantitative with quasi-experiment pre-test-post-test with control group approach. The research respondents are students of semester II in Nursing Diploma Study Program of Health Academy of Karya Husada Yogyakarta totaling 91 people. The research result shows that after getting intervension, the learning motivation of intervension group is higher than control group. The average value of intervension group is 119.19 ± 19.19, while control group is only 100.36 ± 23.26. The learning outcomes of intervension group is higher than control group. The average value of intervension group is 80.21 ± 11.58, while control group is only 60.46 ± 16.32. Therefore, it can be concluded that the improvement of motivation and learning outcomes of students of Nursing Diploma of Health Academy of Karya Husada Yogyakarta in the implementation of learning method of team based learning is higher than lecturing learning method.
Pengaruh Hypnotherapy Terhadap Perubahan Tingkat Nyeri Dismenore pada Mahasiswi STIKes Karya Husada Semarang
Authors: Lestari Sri , Herman Herman
Published: June 2019

Menstruasi adalah perdarahan  vagina secara berkala akibat terlepasnya lapisan endometrium uterus. Rata-rata lebih dari 50%   perempuan   di   setiap Negara mengalami dismenorea. Di Amerika Serikat diperkirakan 45-90%perempuan mengalami dismenorea, dan 12% nyeri berat, 37% sedang, 49% ringan. Di Indonesia angka kejadian dismenorea tidak dapat dipastikan secara mutlak di karena akan kurangnya kesadaran penderita  untuk  berkunjung/melaporkan  ke  dokter.  Boleh  dikatakan  90%  perempuan  Indonesia  pernah mengalami dismenorea. Selain tindakan farmakologis untuk menanggulangi nyeri ada pula tindakan nonfarmakologis untuk mengatasi nyeri, salah satunya yaitu Hypnosis. Tujuan penelitian ini untuk mengetahui pengaruh Hypnotherapy terhadap perubahan tingkat nyeri Diesmenore pada Mahasiswi STIKES Karya Husada Semarang. metode penelitian ini menggunakan Quasi Eksperimental dan menggunakan desain pre-post test with control group dengan pemberian Hypnosis. Pengumpulan data dilakukan sendiri oleh peneliti dan data yang diperoleh dianalisa secara univariat dan bivariat dengan uji t dependent dengan hasil penelitian yang menunjukkan (p= 0.000 dan α= 0,05). Berdasarkan hasil penelitian dan pembahasan dapat disimpulkan bahwa ada pengaruh pengaruh Hypnotherapy terhadap perubahan tingkat nyeri Diesmenore pada Mahasiswi STIKES Karya Husada Semarang.
Hubungan Dukungan Keluarga dengan Tingkat Kehilangan pada Pasien HIV/AIDS di Poliklinik Care Support and Treatment (CST) RSUD Kabupaten Batang
Authors: Sari Rini
Published: June 2019

Data statistik kasus HIV/AIDS  di Indonesia sampai bulan September 2014 orang yang meninggal akibat HIV/AIDS sebanyak 9.796 orang. HIV/AIDS tidak hanya memberikan dampak psikologis yang besar bagi penderitanya. Pasien HIV/AIDS perubahan karakter psikososial yaitu : hidup dalam stres,  depresi,  merasa  kurangnya  dukungan  sosial,  dan perubahan  perilaku.  Tujuan  penelitia  ini untuk mengetahui hubungan dukungan keluarga dengan tingkat kehilangan pada pasien HIV/AIDS di  Poliklinik  Care  Support  and  Treatment  (CST)  RSUD  Kabupaten  Batang.  Metode  :  desain penelitian menggunakan deskriptif korelasi dengan pendekatan cross sectional. Sampel penelitian adalah  pasien  HIV/IDS  di  poliklinik  CST     RSUD  Kabupaten  Batang  sebanyak  50  orang. Pengambilan sampel menggunakan total sampling. Instrumen penelitian adalah kuesioner. Analisa data  menggunakan  uji  chi  square.  Hasil  penelitian  dengan    analisa  univariat  diperoleh  86% responden  mendapatkan  dukungan  keluarga  yang  cukup  dan  60%  responden  melalui  tingkat kehilangan  yang  cukup.  Analisa  bivariat  dengan  chi  square  diperoleh  ρ  value  0,006  <  0,05. Kesimpulan penelitian ini  ada hubungan dukungan keluarga dengan tingkat kehilangan pada pasien HIV/AIDS di Poliklinik Care Support and Treatment (CST) RSUD Kabupaten Batang. Saran untuk perawat adalah dapat memberikan asuhan keperawatan pada pasien HIV/AIDS dengan melibatkan keluarga dalam pemberian konseling pada pasien HIV/AIDS sehingga keluarga dapat mengetahui pentingnya manfaat dukungan keluarga pada pasien HIV/AIDS.
Efektifitas Latihan Progressive Muscle Relaxation Menurunkan Respon Stress Psiko-Fisiologis Pada Mahasiswa Systematic Review
Authors: Astuty Ary
Published: June 2019

Latar Belakang: Perubahan pola aktivitas dan perubahan lingkungan belajar menjadi pemicu stress pada mahasiswa yang melibatkan reaksi psiko-fisiologis. Salah satu intervensi keperawatan yang sering digunakan di klinik untuk mereduksi dampak stress adalah Progresive Muscle Relaxation/PMR, sehingga perlu dilakukan sistematic review untuk mengetahui apakah latihan PMR lebih efektif daripada terapi relaksasi lainnya dalam mereduksi dampak stress psiko-fisiologis. Tujuan: Untuk mengetahui keefektifan latihan PMR daripada terapi relaksasi lainnya dalam mereduksi dampak stress psiko-fisiologis. Metode: Systematic review dilaksanakan dengan menelusuri artikel pada database psychology and behavior sciences collection, googlescholar, gen.lib.rus.ec serta sciencedirect.com dengan kata kunci yang dipilih. Penelusuran dibatasi terbitan 2004-2017 yang dapat diakses fulltext dalam format pdf dengan desain RCT dan Case Control yang dilakukan pada mahasiswa. Perlakuan berupa PMR dibandingkan dengan terapi relaksasi lainnya dalam menurunkan tingkat stress, tingkat kecemasan dan kadar cortisol. Artikel yang sesuai kemudian dianalisis menggunakan critical appraisal tool yang sesuai untuk hasil penelitian RCT maupun Case Control untuk menilai kualitas penelitian. Data-data diekstraksi dari artikel lalu dikelompokkan untuk dibahas dan disimpulkan. Hasil: Tiga dari 5 buah artikel memiliki kualitas tinggi dan yang lainnya sedang.  Hasil pembahasan menunjukkan bahwa latihan PMR lebih efektif menurunkan tingkat stress, tingkat kecemasan dan kadar cortisol pada mahasiswa daripada terapi relaksasi lainnya: pernapasan diafragma, latihan autogenik, small talk grup dan yoga stretching (hatha). Latihan PMR yang paling efektif dilaksanakan selama 30 menit dalam 1 hari dan apabila diterapkan 1 hari dalam seminggu selama 4 minggu akan meningkatkan tingkat relaksasi dan meningkatkan pelepasan energi. Pengulangan sampai 5 minggu dapat meningkatkan indeks kebahagiaan dan ketenangan mental.Kesimpulan: latihan PMR lebih efektif daripada terapi relaksasi lainnya dalam mereduksi dampak stress psiko-fisiologis..                                                                                                            Keywords : progressive muscle relaxation, stress, kecemasan, cortisol, mahasiswa
Pemahaman Keluarga tentang Tindakan ECT Non Premedikasi di RSJD Dr. Amino Gondohutomo Provinsi Jawa Tengah
Authors: Agusman MM Fery , Iswanti Dwi Indah , Lestari Sri Puji
Published: June 2019

Kesehatan jiwa masih menjadi salah satu permasalahan kesehatan yang signifikan di dunia, termasuk di Indonesia. Salah satu bentuk terapi penanganan kesehatan jiwa adalah Electro Convulsive Therapy. Terapi ECT merupakan suatu jenis pengobatan somatik dimana arus listrik digunakan pada otak melalui elektroda yang ditempatkan pada pelipis. Studi ini eksplorasi pemahaman keluarga tentang tindakan ECT non premedikasi di RSJD Dr. Amino Gondohutomo Provinsi Jawa Tengah.Tujuan penelitian ini adalah mengeksplorasi pemahaman keluarga tentang tindakan ECT non premedikasi di RSJD Dr. Amino Gondohutomo Provinsi Jawa Tengah.Desain penelitian yang digunakan adalah desain penelitian deskriptif kualitatif. Partispisan dalam penelitian ini adalah 3 orang keluarga pasien yang mendapatkan terapi ECT non premedikasi ≥2 kali.Hasil penelitian menunjukkan responden mampu menjelaskan definisi ECT non premedikasi sebagai menggunakan aliran listrik untuk menimbulkan kejang, indikasi pada pasien dengan resistensi obat dan gejala psikotik, manfaat ECT premedikasi mempercepat kesembuhan, dampak ECT non premedikasi adalah terjadi mual muntah, amnesia sementara, dan gigi goyang.Diharapkan petugas kesehatan dapat membantu keluarga pasien yang anggota keluarganya dilakukan ECT Non Premedikasi untuk memberikan edukasi tentang pengertian, indikasi, manfaat dan prosedur ECT Non Premedikasi. Kata kunci : Pemahaman keluarga, ECT Non Premedikasi Family's Understanding Of The Non-Premedicated ECT Treatment In The RSJD. Amino Gondohutomo Central Java Province. Abstract Mental health is  one of the most significant health problems in the world, including in Indonesia. The one of mental health treatment therapy is Electro Convulsive Therapy. ECT therapy is a type of somatic treatment in which electrical current is used in the brain through electrodes placed at the temples. This study explores the family's understanding of the non-premedicated ECT treatment in the RSJD. Amino Gondohutomo Central Java Province.The research design that be used was descriptive qualitative research design. Participants in this study were 3 family of patients that  receiving non-premedicated ECT therapy ≥2 times in the RSJD. Amino Gondohutomo Central Java Province.The results of the study showed that respondents were able to explain the definition of non premedication ECT as using the flow of electricity to cause seizures, indications in patients with drug resistance and psychotic symptoms, the benefits of premedication ECT accelerate recovery, non-premedication ECT effects were nausea vomiting, temporary amnesia.The health workers should be can help families of patients whose family members have ECT Non Premedication to educate about the understanding, indication, benefits and procedures of ECT Non Premedication. Keywords              : family's understanding, non-premedicated ECT
Motivasi Mahasiswa Berhubungan dengan Tingkat Kecemasan Menghadapi Tugas Akhir
Authors: Haiya Nutrisia Nuim
Published: June 2019

LatarBelakang: Motivasi pada mahasiswa mempunyai dampak negatif dan dampak positif terhadap kegiatan mahasiswa tersebut, dampak positifnya akan melakukan kegiatan dengan penuh semangat akan tetapi dampak negatifnya akan mengakibatkan kecemasan. Kecemasan adalah sesuatu yang dirasakan seperti kebingungan, rasa takut, rasa yang tidak menentu dan tidak berdaya serta kegelisahan. Penelitian ini bertujuan untuk mengetahui hubungan motivasi dengan kecemasan mahasiswa menghadapi tugas akhir. Metode:Penelitian ini merupakan jenis penelitian survei analitik dengan studi cross sectional. Pengumpulan data dilakukan dengan kuesioner. Jumlah responden sebanyak 94 mahasiswa dengan tehnik Total Sampling.Data yang diperoleh diolah secara statistik dengan menggunakan Spearmen. Hasil:Hasil didapatkan bahwa ada hubungan signifikan antara motivasi dengan kecemasan pada mahasiswa tingkat akhir (p= 0,0009) dengan r= 0,270. Simpulan : motivasi mahasiswa berhubungan dengan tingkat kecemasan yang sedang dihadapi oleh mahasiswa tingkat akhir. Kata Kunci : Motivasi; kecemasan; mahasiswa
Studi Fenomenologi Perilaku Homoseksual Di Kota Semarang
Authors: Puji Lestari Sri , Wulaningsih Indah , Fitriyah Lailatul
Published: June 2019

Homoseksual merupakan masalah global dan modern sekarang ini, gaya hidup atau lifestyle merupakan hal yang sangat penting dan kerap menjadi ajang untuk menunjukkan identitas diri. Saat ini cukup banyak komunitas dan organisasi homoseksual baik formal maupun informal. Tujuan penelitian ini adalah mendeskripsikan fenomena perilaku homoseksual di Kota Semarang.Desain penelitian yang digunakan adalah desain penelitian fenomenologi kualitatif. Partispisan dalam penelitian ini adalah 4 orang homoseksual yang berada dalam sebuah komunitas homoseksual di kota Semarang. Hasil penelitian menunjukkan partisipan berteman baik dengan siapapapun, partisipan melakukan hubungan seksual dengan berbagai  cara, baik oral , bodycontact dan anal. Diharapkan untuk para homoseksual agar dapat berperilaku secara baik dalam perilaku sesksual maupaun perilaku secara umum sesuai kaidah di masyarakat agar kehadirannya dapat diterima dalam lingkungan.Kata Kunci:  homoseksual; perilaku
Expression of cytochrome P450 2C9 (CYP2C9) in Escherichia coli and its functional characterization
Authors: Tan Boon Hooi , Pan Yan , Palanisamy Uma Devi , Othman Iekhsan , Ahmed Nafees , Yap Beow Chin , Ong Chin Eng
Published: June 2019

This study aimed to express the major human hepatic drug metabolizing cytochrome P450 (CYP), CYP2C9, together with NADPH cytochrome P450 oxidoreductase (OxR) in Escherichia coli and to evaluate its catalytic activities. Co-expression of CYP2C9 and OxR was achieved by means of separate, compatible plasmids with different antibiotic selection markers. The expressed proteins were evaluated by immunoblotting and reduced CO difference spectral scanning. Enzyme activities were examined using high performance liquid chromatography (HPLC) assays with probe substrates valsartan and tolbutamide. Results from immunoblotting demonstrated the presence of CYP2C9 protein in bacterial membranes and reduced CO difference spectra of the cell preparations exhibited the characteristic absorbance peak at 450 nm. Co-expressed OxR also demonstrated an activity level comparable to previously published data. Kinetic parameters, Km and Vmax values determined from the valsartan and tolbutamide hydroxylase assays, were also concordant with literature values. As a conclusion, the procedures described in this study provide a relatively convenient and reliable means of producing catalytically active CYP2C9 suitable for drug metabolism and interaction studies.