bluuebunny/crossref_metadata_2025 huggingface dataset:
First‐Pass Effect With Aspiration Thrombectomy With the Penumbra System in Patients With Acute Ischemic Stroke: A Core Laboratory–Adjudicated Subset Analysis of the COMPLETE Registry
Authors: Fifi Johanna T. , Matsoukas Stavros , Hassan Ameer E. , Zaidat Osama O.
Published: February 2023

Background

In patients with acute ischemic stroke, minimizing the time to revascularization can minimize neuronal death. First‐pass effect (FPE), defined as successful or complete revascularization of an occluded target vessel with 1 pass of a mechanical thrombectomy device(s), reduces the time to revascularization. The objective of this study was to determine the FPE rate, compare cases in which FPE was versus was not achieved, and determine predictors of good functional outcome at 90 days, in patients with large‐vessel occlusion acute ischemic stroke treated with the Penumbra System (Penumbra, Inc).

Methods

This study is a subset analysis of the COMPLETE (International Acute Ischemic Stroke Registry With the Penumbra System Aspiration Including the 3D [3‐Dimensional] Revascularization Device) registry, a global, prospective, multicenter, observational registry. FPE rates were calculated. Subgroups who achieved versus did not achieve FPE were compared. Variables independently associated with good functional outcome at 90 days were determined.

Results

A total of 648 patients were included. FPE was achieved with a revascularization definition of modified thrombolysis in cerebral infarction score 2b to 3 in 56.8% of patients, with modified thrombolysis in cerebral infarction score 2c to 3 in 41.5%, and with modified thrombolysis in cerebral infarction score 3 in 31.8%. The percentage of patients who achieved good functional outcome at 90 days was higher for patients who achieved FPE than for patients who did not (
P
<0.01). Achieving FPE with modified thrombolysis in cerebral infarction score 2b to 3 was an independent predictor for good functional outcome at 90 days (adjusted odds ratio, 1.64;
P
=0.045).

Conclusions

For aspiration thrombectomy with the Penumbra System, achieving FPE was associated with a significantly higher rate of good functional outcome.
In‐Room Direct Nidal Flow Measurement by Digital Subtraction Angiography to Estimate Hemorrhage Risk in Brain Arteriovenous Malformations: A Pilot Study
Authors: Chen Ko‐Kung , Yang Huai‐che , Lee Cheng‐Chia , Lin Chun‐Fu , Chu Wei‐Fa , Hsu Sanford PC. , Chang Feng‐Chi , Su I‐Chang , Chiou Hong‐Jen , Lin Chung‐Jung
Published: February 2023

Background

Noninvasive direct flow measurement from digital subtraction angiography (DSA) is challenging in brain arteriovenous malformations (BAVMs). We devised a method to estimate the blood volume flow rate of BAVM nidus using DSA, and assessed its association with angioarchitecture features in hemorrhagic presentation.

Methods

A total of 24 patients with BAVMs (10 controls and 14 with hemorrhage) who underwent DSA and magnetic resonance (MR) were retrospectively recruited. Fifteen patients underwent additional phase contrast MR imaging. The nidus volume was contoured on the MR time‐of‐flight data set. From DSA, flow velocities and volume flow rate were estimated along calibrated vascular center lines. The BAVM nidus volume flow rate was computed by adding feeding volume flow rate of arteries confirmed on DSA and then normalizing them with nidus volume to yield the nidus flow index. The correspondent phase‐contrast MR‐estimated nidus flow index was evaluated in each BAVM for comparison. Comparisons of hemodynamic parameters of the control and hemorrhage groups were conducted using the Wilcoxon rank sum test. A support vector machine was used for classifying BAVM patients using angioarchitectures and the nidus flow index.

Results

For the DSA results, the nidus flow index was higher in the hemorrhagic group than in the control group (
P
=0.0272). The flow index determined using phase‐contrast MR and nidus volume were not significant. The classification accuracy was higher when the DSA nidus flow index was added into angioarchitecture.

Conclusion

The BAVM nidus flow index can be directly estimated from DSA and may be associated with hemorrhagic BAVM. Peritherapeutic hemodynamic assessment of BAVMs inside the angio‐suite is feasible.
Approachability and Credibility of Virtual Character Faces: The Role of the Horizontal Viewing Angle
Authors: So Chaehan , Jung Kyuha
Published: February 2023

Objective

The present work explores how the horizontal viewing angle of a virtual character’s face influences perceptions of credibility and approachability.

Background

When encountering virtual characters, people rely both on credibility and approachability judgments to form a first impression of the depicted virtual character. Research shows that certain perceptions are preferred either on frontal or tilted faces, but not how approachability or credibility judgments relate to horizontal viewing angles in finer granularity between 0° and 45°.

Method

52 participants performed a two-alternative forced choice (2AFC) task rating 240 pairwise comparisons of 20 virtual character faces shown in four horizontal viewing angles (0°, 15°, 30°, and 45°) on approachability and credibility. They also rated scales on individual differences based on the BIS-BAS framework (behavioral inhibition system, drive, and reward responsiveness), self-esteem, and personality traits (neuroticism, loneliness).

Results

Both approachability and credibility were negatively related to the horizontal viewing angle, but the negative relationship was less pronounced for approachability. Notably, 15° tilted faces were associated with higher approachability than frontal faces by people scoring high in reward responsiveness, drive, and self-esteem, and scoring low in neuroticism and loneliness.

Conclusion

Our findings highlight the conditions under which showing a virtual character’s face is preferred in a horizontally 15° tilted over a frontal position.

Application

The differential impact of the horizontal viewing angle on approachability and credibility should be considered when displaying virtual character faces.
Electoral Integrity, the Concession of Power, and the Disciplining Role of Protests
Authors: Duley Chanelle , Gai Prasanna
Published: February 2023

Coordination on mass protest plays an important disciplining role in ensuring compliance with electoral rules, with elections serving as a public signal of the incumbent’s popularity. But the link between the informativeness of the election and the enforceability of electoral rules hinges crucially on the veracity of the electoral process. We model how doubt about electoral integrity influences compliance with electoral rules. Our analysis explains why electoral rules in advanced democracies are less resilient, and incumbents less willing to step aside, than suggested by the standard model of electoral turnover. We clarify how incumbent behaviour responds to changes in the cost of protest, and external overtures that make stepping down more attractive. Our findings contribute to the debate on the role of equilibrium multiplicity in models of mass uprisings.
Social Media Marketing Practices of Illinois Recreational Cannabis Dispensaries in the First Year of Legal Sales: Product Promotions, Branding, and Price Promotions
Authors: Marinello Samantha
Published: February 2023

Research from tobacco suggests that the recreational cannabis industry will use aggressive tactics, including product innovation and mass-marketing and advertising, to increase demand for their products. The purpose of this study is to examine product promotions, branding, and promotional pricing on recreational dispensary social media pages in the state of Illinois in the first year of legal sales. Data were collected from all recreational cannabis dispensary Facebook and Twitter accounts and a quantitative content analysis was used to analyze the data. Differences in marketing practices were assessed by neighborhood race/ethnicity and income and dispensary type. Results of the study revealed that flower and edibles were the two most heavily promoted products; promotions for vaporizers and concentrates were also promoted frequently. Posts with branded promotions and price promotions increased substantially over the year. Research suggests that this trend in marketing practices will lead to greater initiation and intensity of cannabis use.
Resources Available for Me Versus Us: Implications for Mitigating Consumer Food Waste
Authors: Gao Huachao , Jia He (Michael) , Guo Bingxuan
Published: February 2023

Although food waste is an urgent issue with widespread economic, societal, and environmental impacts, it remains understudied in the marketing discipline. This is surprising, since most food waste occurs at the retail and consumption stages of the food life cycle. This research fills this gap by examining how resource mindset and self-construal jointly shape consumer food waste. Specifically, inducing a scarcity mindset signals that there is no resource to waste, mitigating consumer food waste regardless of self-construal. In contrast, under an abundance mindset, where there is resource to waste, activating an interdependent (vs. independent) self-construal can effectively reduce consumer food waste. The authors identify sharing obligation, the tendency to share valuable resources with in-groups, as a key mechanism behind the effect. In support of this mechanism, enhancing sharing obligation (e.g., highlighting the sharing concept, highlighting others’ food needs) or diminishing it (e.g., highlighting family resource abundance) attenuates the effect of self-construal on consumer food waste under an abundance mindset. The results from one large-scale field study, four controlled experiments, and a country-level secondary data analysis provide convergent support for the proposed framework. This research not only contributes to the related literature but also provides actionable strategies for mitigating consumer food waste.
The physicality of mindsports through elite bridge players’ sensorial experiences: Presence, confidence and bodies
Authors: Scott David S. , Punch Samantha
Published: February 2023

The classification of mindsports such as the card game of bridge within sport and society continues to be keenly debated. The concept of ‘physicality’ is often cited as being a prerequisite for an activity to be classed as a ‘sport’, a characteristic typically seen as lacking in mindsports. However, by drawing upon monist conceptualisations of the mind, body and world being intertwined, it is possible to problematise such arguments by highlighting the interconnected sensations experienced when participating in bridge. This article explores such a notion through phenomenologically-inspired analysis of 52 interviews with elite-level bridge players. The findings detail the importance players placed upon aspects of kinaesthesia, physical presence within the competitive environment, and the role of other social actors within their own understandings of their competition experience. These sensorial, emotional and embodied accounts of elite-level bridge shed light on the physical negotiations and socio-cultural influences involved in mindsport, which allude to a greater degree of ‘physicality’ than has previously been discussed.
Animating sociology
Authors: Bates Charlotte , Moles Kate , Kroese Lily Mae
Published: February 2023

This article outlines the collaborative process of making a watercolour animation drawn from research with women who swim wild in rivers, lakes and seas. Discussing graphic storytelling in sociology, anthropology and related disciplines, we share our experiences of creative collaboration, describing in detail the practical process of making a research-led animation to share with the wider swimming community and situating the project within a larger discussion of graphic and public ethnography, live methods and the possibilities of representation. The article contributes to the ways we can make methods lively and shows how we can both literally and metaphorically animate sociology.
Young Low-Income Mothers’ Identity Work around Infant Feeding in the UK
Authors: Banister Emma , Hogg Margaret K , Dixon Mandy
Published: February 2023

This article focuses on young low-income mothers’ engagement with, and management of, potentially conflicting discourses within the context of maternal foodwork. Findings from qualitative, longitudinal interviews with 13 UK women illustrate the performance of identity and family work, in relation to infant feeding and wider maternal practices. Each participant was interviewed twice, once prior to, and then following, the birth of their first baby. We identify three rhetorical strategies. Adopting and resisting allow for the acceptance or rejection of prominent infant feeding discourses. Under reframing, young women transform the encouragement to breastfeed, subverting or reversing official discourses. Reframing thus provides an alternative means to appropriate and deploy versions of good motherhood, drawing on women’s lived realities and local maternal cultures, alongside wider experiences of building and managing family relationships.
Power and partnership: Implications of redeemed patronage in missional context
Authors: de Freitas Rennae
Published: February 2023

This article examines some historical and missiological contexts of the Western conception of partnership in mission and critiques how partnership fails in the Majority World. It then addresses how power is navigated in patron–client systems. Finally, drawing on the work of Jayson Georges, it offers a contextual approach to redeeming patronage in a missional context and discusses the implications for authentic, intercultural relationships.
Onlife intersectionalities as flows of playbour: The case of women in gaming
Authors: Just Sine N , Storm Kai , Bukuru Sandra-Louise
Published: February 2023

Digital capitalism troubles classical notions of contextual singularity and agential unity and destabilises delineations of online and offline realities. Following Floridi, this paper applies the concept of ‘onlife’ for the ‘new experience of a hypermediated reality’, and we contribute to the understanding of this experience by highlighting the socioeconomic entanglements of users’ self-expression and technological corporations’ profiteering. We introduce the notion of onlife intersectionalities, where intersectionalities are understood as the enactment of identities at the crossroad of gender, race, sexuality, class, etc., and add the dimension of commercial interest to better conceptualise dynamics of empowerment and exploitation. Thus, we suggest that onlife intersectionalities are enacted in and as flows of playbour that produce surplus value through playful activity. Seeking empirical substance for these conceptual relations, we turn to the case of women in online gaming. Focusing on three individual women gamers’ onlife trajectories and flows of playbour, we show how these interact differently for each gamer, leading to more play with higher rewards for some and more labour with less compensation for others. With this analysis, we illustrate the exploitation-cum-empowerment of human subjects under digital capitalism.
Trade unions negotiating the Swedish model: racial capitalism, whiteness and the invisibility of race
Authors: Mulinari Paula , Neergaard Anders
Published: February 2023

In October 2022, a new employment protection regulation, often seen as a core aspect of the Swedish model of industrial relations, was implemented in Sweden. While the debate around the new regulation was heated, one interesting omission was that, in the unions’ advocacy for maintaining various forms of labour market security, the racialised labour market was never discussed, despite a strong racially segmented labour market with varying working conditions. In this article we explore how three white, male-dominated trade unions representing employees in different class locations positioned themselves around the change in the new Employment Act. Inspired by contributions on racial capitalism, we unravel how trade unions take part in the contestation over industrial relations in a context in which neoliberal and ethnoracial policies are growing. Using the ‘Swedish model’ as an ‘empty signifier’ – highly variable in meaning, hence contestable – we find that the unions advance three different positions on employment protection regulation: flexible, skilled and protective, and in doing so contribute to the self-racialisation of white male workers in working life.
Quaternary glaciations in western China: A review of the chronologies established by absolute dating
Authors: Li Yanan , Fu Ping , Chen Renrong , Li Yingkui
Published: February 2023

Quaternary glaciations in western China have been investigated over the last century with the emphasis on the Tibetan Plateau and its adjacent regions. Earlier studies were mainly based on field observation and interpretation of geomorphic landforms and processes to identify and define past glacial sequences. The advent of absolute dating techniques, such as optically stimulated luminescence dating and cosmogenic radionuclide exposure dating, has revolutionized glacial chronological research in recent decades. Glacial chronologies have been established across various mountains, providing evidence to reject the Tibetan ice sheet hypothesis. Glacial advances generally occurred synchronously in this region, but the detailed timing, extent, and form of past glaciers vary at different locations. This review presents recent progress and challenges on reconstructing the timing and extent of Quaternary glaciations in western China, seeking to promote further studies and a broader interest from the physical geography community in this critical region.
Assessment of an Online Nutrition Education Program to Improve Mealtime Practices Among Families Receiving SNAP and WIC
Authors: Tripicchio Gina L. , Anderson Jennifer
Published: February 2023

Purpose

This study examines if participation in an online nutrition education program holds promise for improving mealtime practices in families using SNAP and WIC.

Design

Pre-post self-report surveys.

Setting

Digital program delivered online, nationally in the United States.

Sample

Two hundred fifty-seven parents receiving SNAP and/or WIC.

Intervention

Parents signed up to participate in Affordable Flavors, an online self-guided 30-day meal plan, developed by culturally diverse dietitians, aligned with the Dietary Guidelines, and linked with social media support.

Measures

Overall program utilization and acceptability were assessed along with parent meal preparation practices, diet quality of meals served to children, self-efficacy, mealtime stress, grocery spending, and food insecurity.

Analysis

Paired t-tests (continuous variables) and McNemar’s tests (categorical variables).

Results

Overall program utilization and acceptability were high. Participants reported improvements in meal preparation practices (t(255) = 6.6, P < .001), diet quality of meals served to children (t(245) = 4.0, P < .001), and self-efficacy (t(251) = 10.0, P < .001), and decreases in grocery spending (t(175) = -4.3, P < .001), mealtime stress (t(256) = -8.8, P < .001) and food insecurity (26.8% vs 10.9%, P < .001).

Conclusion

Affordable Flavors is an acceptable, cost-effective, and easily disseminatable program that holds promise for improving parent self-efficacy to prepare and serve healthy meals to children and increase diet quality in families receiving SNAP and WIC. Engaging online nutrition education programs that can be used by a variety of health professionals, especially in settings where direct nutrition education services are not feasible or cost prohibitive, are needed.
MAPK-interacting kinases inhibition by eFT508 overcomes chemoresistance in preclinical model of osteosarcoma
Authors: Huang Bin , Jin Peicheng , Yi Kaijun , Duan Junhu
Published: February 2023

The MAPK-interacting kinases 1 and 2 (MNK1/2) have generated increasing interest as therapeutic targets for many cancers with little known in osteosarcoma. This study evaluated the efficacy of eFT508, a highly selective inhibitor of MNK1/2, as single drug alone and in combination with paclitaxel in preclinical models of osteosarcoma. EFT508 is active against multiple osteosarcoma cell lines via inhibiting growth, survival and migration. It also demonstrates anti-osteosarcoma selectivity with much less toxicity on normal osteoblastic than osteosarcoma cells. Consistent with in vitro findings, eFT508 at non-toxic dose significantly arrested tumor growth in mice throughout the whole duration of treatment. Mechanistically, eEFT508 is highly effective in blocking eIF4E phosphorylation and eIF4E-mediated protein translation. Combination index shows that eFT508 and paclitaxel is synergistic in osteosarcoma cells. Our findings highlight the therapeutic value of MNK1/2 inhibition and suggest eFT508 as a promising candidate for the treatment of osteosarcoma.
Systematic review of ethical issues in perinatal mental health research
Authors: de Wet Mickie , Hannon Susan , Hannon Kathleen , Axelin Anna , Uusitalo Susanne , Bartels Irena , Eustace-Cook Jessica , Escuriet Ramón , Daly Deirdre
Published: February 2023

Background

Maternal mental health during the peripartum period is critically important to the wellbeing of mothers and their infants. Numerous studies and clinical trials have focused on various aspects of interventions and treatments for perinatal mental health from the perspective of researchers and medical health professionals. However, less is known about women’s experiences of participating in perinatal mental health research, and the ethical issues that arise.

Aim

To systematically review the literature on the ethical issues that emerge from pregnant and/or postpartum women’s experiences of taking part in perinatal mental health-related research.

Methods

Systematic review of nine bibliographic databases, from inception to July 2021. Qualitative, quantitative and mixed method studies were included if they reported on ethical issues experienced by perinatal women. Research ethical issues encompassed any issue relating to women’s experiences of being offered study information, recruitment, consent, retention and respect for autonomy. Titles, abstracts and full text screening, appraisal of the methodological quality of included studies, and data extraction, were conducted independently by two reviewers.

Ethical considerations

Ethical approval was not required for this systematic review.

Findings

A total of 9830 unique citations was retrieved. Six studies met the inclusion criteria. Studies were clinically and methodologically heterogenous, and only one was purposively designed to explore women’s experiences. The key finding was the establishment of trust between the researcher and participant in all stages of the research process. Findings are presented according to recruitment and consent processes, participation and retention, and study follow-up and completion.

Conclusion

The establishment of trust between the researcher and perinatal women leads to a dynamic with research ethical implications relevant to all stages of perinatal mental health-related research. Further research on the research ethical issues experienced by perinatal women is required because of the limited literature.
Positioning of psychodynamic psychotherapy in the treatment of depression: A comparison of the RANZCP 2020 and NICE 2022 guidelines
Authors: Malhi Gin S , Bell Erica , Bassett Darryl , Boyce Philip , Hazell Philip , Hopwood Malcolm , Lyndon Bill , Mulder Roger , Porter Richard , Murray Greg
Published: February 2023

Objective

To compare the 2022 NICE guidelines (NG222) and 2020 RANZCP clinical practice guidelines (MDcpg2020) recommendations for the treatment of depression using psychodynamic psychotherapy.

Conclusions

Both guidelines recommend psychological interventions first-line. However, only short-term psychodynamic psychotherapy (STPP) is recommended, and in the NG222 it is ranked last for less severe depression and 7th for more severe depression. In contrast, cognitive behavioural therapy and behavioural activation are deemed the more clinically effective and cost-effective psychological therapies. And antidepressants play a significant role – largely in more severe depression.
Using a mobile application for psychiatry training in medical students: a quasi-experimental study
Authors: Zolfaghari Mitra , Shirzadi Shahriar , Motamed Mahtab
Published: February 2023

Objective

Microlearning and gamification through mobile technology can significantly enhance knowledge acquisition and satisfaction. Roozbehyar application, was designed using microlearning and gamification approaches for psychiatry clerkship training.

Method

This quasi-experimental study was conducted in Roozbeh Hospital, in 2021. The intervention group was assigned to the Roozbehyar during a 4-week course. Knowledge and satisfaction were assessed after 4 weeks.

Results

We recruited 27 (F/M: 19/8) and 35 students (F/M: 22/13) in the intervention and control groups, respectively. Learning through Roozbehyar was associated with higher scores in the final written exam ( p value: 0.031). No difference was seen in the final global assessment scores. The satisfaction scores of the students regarding the content and learners’ aspect of the application were above average, yet scores in structural and support aspects were below average.

Conclusions

We highlighted the effect of a microlearning mobile application in increasing knowledge and satisfaction in psychiatry training in medical students.
Updates in the Treatment of Non-Metastatic Castrate-Resistant Prostate Cancer: The Benefit of Second-Generation Androgen Receptor Antagonists
Authors: Hadfield Matthew J. , Lyall Vikram , Holle Lisa M. , Dennison Morgan
Published: February 2023

Objective:

To review pharmacology, efficacy, safety, and considerations for use, of second-generation androgen receptor (AR) antagonists in treatment of nonmetastatic castrate-resistant prostate cancer (M0CRPC).

Data Sources:

Conducted search in PubMed and Google scholar (January, 1, 2002—December 31, 2022), using relevant terms.

Study Selection and Data Extraction:

Relevant English-language studies, conducted in humans evaluating second-generation AR antagonists for M0CRPC, and additional articles and package inserts were considered.

Data Synthesis:

Apalutamide, darolutamide, and enzalutamide are effective in delaying the time to development of metastatic prostate cancer in men with M0CRPC with a rapid prostate-specific antigen (PSA) doubling time (<10 months). No head-to-head, randomized, clinical trials have been conducted. The most common adverse effects include fatigue and hypertension, and quality of life is maintained in most patients. Cost is similar among the agents (~$15,000/month). Drug-drug interactions vary among these agents and should be considered, when selecting therapy as well as likely adherence. Darolutamide is administered twice daily with the others once daily.

Relevance to Patient Care and Clinical Practice:

Second-generation AR antagonists are effective in reducing time to development of metastatic disease and prolonging overall survival in patients with M0CRPC and a PSA doubling time of <10 months. Recent imaging advances may alter how we evaluate outcomes.

Conclusions:

Second-generation AR antagonists improve disease control and overall survival. Generally, they are well tolerated and QOL is maintained. Selection of the best agent is based on the adverse effect profile, potential for drug- and disease-interactions, administration, cost, and patient preference.
Acute Management of Hypertriglyceridemia With a Disease-Specific Intravenous Insulin Infusion Order Set
Authors: Ibarra Francisco
Published: February 2023

Background:

Hypertriglyceridemia-associated acute pancreatitis is a disease lacking a standardized management approach.

Objective:

The main objective of this study was to evaluate the safety and efficacy of a continuous intravenous insulin infusion order set specifically designed for managing hypertriglyceridemia.

Methods:

This study compared the safety and efficacy of a standardized (postintervention) approach to managing hypertriglyceridemia to a nonstandardized (preintervention) approach. The primary efficacy outcome was the percentage of patients who achieved a triglyceride level less than 500 mg/dL. Additional outcomes included the time to achieving a triglyceride level less than 500 mg/dL and the percent reduction in triglyceride levels. The primary safety outcome was the number of patients who experienced hypoglycemia (glucose less than 70 mg/dL).

Results:

Twenty patients were included in both the preintervention and postintervention groups. There was a significantly greater reduction in triglyceride levels observed in the postintervention group. The number of patients who achieved a triglyceride level less than 500 mg/dL in the preintervention and postintervention groups were 10 (50%) and 17 (85%), respectively, P = 0.018. Within the postintervention group, the time to achieving a triglyceride level less than 500 mg/dL in those with and without diabetes was 56.8 hours (38.2-64.0) versus 27.6 hours (19.7-45.0), respectively, P = 0.028.

Conclusion and Relevance:

Our findings demonstrate that insulin infusions are safe and effective when therapy is standardized and accounts for nursing to patient ratios. Our results provide the medical community with a standardized approach to acutely managing hypertriglyceridemia.
Unusual Microsatellite-Instable Mixed Neuroendocrine and Non-neuroendocrine Neoplasm: A Clinicopathological Inspection and Literature Review
Authors: Pereira Daniela , White Daley , Mortellaro Michael , Jiang Kun
Published: February 2023

Background

Mixed neuroendocrine and non-endocrine neoplasms (MiNENs) are challenging to diagnose and manage clinically. The current understanding of MiNENs’ pathobiology, molecular mechanisms, and management is incomplete. Though microsatellite instability (MSI) is known to impact carcinogenesis, reports examining MSI mechanisms for MiNENs are rare.

Methods

We report an unusual colonic MSI-MiNEN uncovered in an 89-year-old woman and the review of the literature.

Results

Pathologic inspection revealed a high-grade carcinoma composed of tumor cells with neuroendocrine histologic traits and immunophenotype intermixed with mucin-containing signet ring–like cells arranged in nested and micronodular patterns. Loss of MLH1 and PMS2 mismatch repair proteins was detected in tumor cells. INSM1 immunostaining highlighted about 50% of the tumour, further reinforcing the MiNEN diagnosis. Next-generation sequencing identified multiple carcinogenic mutations. Because of the advanced stage of the tumor and its adhesion to the adjacent organs, surgical resection was aborted; immunotherapy was initiated. The tumor is in remission 30 months following initiation of treatment, and the patient remains asymptomatic.

Conclusion

This unique MSI MiNEN was characterized by its immunohistochemical and molecular signatures and illustrated how correctly diagnosing MSI can strongly improve a patient’s outcomes.
The Sacred Space: Using Stages of Change Model With Motivational Interviewing to Promote Patient-Centered Healing
Authors: Dixon Lynette , Berger Carol , Smalley Brandie
Published: February 2023

Objective:

Help patients make necessary life changes to reach desired health outcomes.

Methods:

By combining the transtheoretical stages of the change model with motivational interviewing, nurse practitioners can hone powerful skills to enable patients to make their desired life changes.

Results:

Nurses and nurse practitioners can make a difference in patients’ lives by connecting and partnering with them to create positive change for improved health outcomes.

Conclusions:

Nurse educators should provide opportunities for nurses at all levels to learn and incorporate these skills into their practice.
The Social Production of the Dead Human Body in the Practice of Teaching Anatomy Through Cadaveric Dissection
Authors: Burr Jennifer , Russell-Sewell Nigel
Published: February 2023

The aim of this study is to explore how the dead human body is socially produced through the practices of those involved in teaching anatomy through cadaveric dissection. The perspectives of anatomists learning to teach offer a novel perspective on the existing literature. The study draws on data from interviews with students and teaching staff involved in practical cadaveric dissection during a UK postgraduate anatomy education programme. Interviews addressed participants’ experiences, reflections, and emotional responses during practical dissection of donor bodies. Findings address five areas: anticipation and the ‘imagined body’, ontology and the latent human, detachment, dissociation, and reconciliation, preparation and intentionality, and gratitude and immortalisation. The findings suggest that during the course of practical dissection sessions, anatomists learn to normalise the transgressive activity of human dissection via processes of reconciliation. The transgressive elements are resolved through the agency of the person once living and through a configuration of the anatomist and the donor body in a network of scientific knowledge, pedagogic practice and personal influence.
Online writing instruction: Understanding university EFL instructors’ beliefs and practices as a complex system
Authors: Abdelhalim Safaa M.
Published: February 2023

With ongoing debates about the nature and constituents of effective online writing instruction, little is known about the beliefs and practices of online writing instructors. Most studies conducted on language teachers’ beliefs focused primarily on examining the relationship between teachers’ beliefs and practices based on static views, which are represented as a simplified linear or dual relationship. Complexity theory (CT) goes beyond this reductionist framework by understanding not only the components of teachers’ beliefs and practice systems but also how these components interact and mutually inform each other, creating new entities. Guided by CT perspectives, this article reports and analysis data from a multiple-case study on two experienced Saudi university English as a foreign language (EFL) writing instructors’ beliefs and practices concerning online writing instruction (OWI). Data collection included three sources: semi-structured interviews, classroom observations, and document analysis. The study findings revealed that, first, the belief systems of the two instructors incorporated various interrelated and interactive beliefs and sub-beliefs in three main areas: online writing, OWI, and online writing assessment and feedback giving; second, the complex dynamic interactions between the diverse constituents of both instructors’ beliefs and practice systems played an influential role in determining whether instructors were ready to engage with and adapt pedagogical practices for OWI. The overall findings revealed two distinct belief systems within the two cases concerning engagement with OWI: one humanistic-oriented and the other structural-oriented. The study proposes a series of pedagogical and professional best practices relevant to online writing instruction.
Short report: The role of oral hypersensitivity in feeding behaviors of young autistic children
Authors: Thompson Kelsey , Wallisch Anna , Nowell Sallie , Meredith Jessica , Boyd Brian
Published: February 2023

Feeding problems are common among autistic children and are linked to negative health consequences. Therefore, understanding feeding problems and factors that influence these behaviors is important for developing supports for children and families. While certain sensory processing patterns are commonly associated with feeding problems, less is known about the link between sensory processing and feeding behaviors in autism, as well as how parent behaviors and feelings during mealtime differ based on child sensory preferences. This research examined two groups of young autistic children who were reported to be picky eaters by their parents: those with and those without oral hypersensitivity. Children with oral hypersensitivity had more difficulty with food acceptance, and their parents reported more negative feelings around feeding their child. However, the two groups of children (oral hypersensitive and not) did not differ in their medical/oral motor symptoms, mealtime behavior, or parent use of strategies at mealtimes. This research supports the need for personalized treatment strategies based on the child’s sensory preferences to support both the child and parent in managing mealtimes.

Lay abstract

Feeding problems are common among autistic children and are linked to negative health consequences. Therefore, understanding feeding problems and factors that influence these behaviors is important for developing supports for children and families. While certain sensory processing patterns are commonly associated with feeding problems, less is known about the link between sensory processing and feeding behaviors in autism, as well as how parent behaviors and feelings during mealtime differ based on child sensory preferences. This research examined two groups of young autistic children who were reported to be picky eaters by their parents: those with and those without oral hypersensitivity. Children with oral hypersensitivity had more difficulty with food acceptance and their parents reported more negative feelings around feeding their child. However, the two groups of children (oral hypersensitive and not) did not differ in their medical/oral motor symptoms, mealtime behavior, or parent use of strategies at mealtimes. This research supports the need for personalized treatment strategies based on the child’s sensory preferences to support both the child and parent in managing mealtimes.
Decolonising Youth Justice, Rethinking Childhood: Caribbean Counterstories in Detention
Authors: Mutsaers Paul
Published: February 2023

This article offers counterstories from a Caribbean youth detention centre in support of an agenda to decolonise youth justice and rethink childhood. It contrasts the youth’s own ‘ethics of illegality’ centred on structural violence and inequality with institutional interventions revolving around individual remedies and risk factors as well as culturally specific but peculiarly Western conceptions of parenthood and childhood. Concerned about the exclusive ways of regulating and defining parenthood, childhood and safety that stem from a globalisation of youth crime control, the article calls for a vernacularisation that takes seriously the complexity and context-dependency of young people’s lives.
The effect of correlated colour temperature and wall luminance on spatial brightness and scene preference in a windowless office setup
Authors: Van de Perre L , Smet KAG , Hanselaer P , Dujardin M , Ryckaert WR
Published: February 2023

This study explores the impact of wall luminance and correlated colour temperature (CCT) on the observers’ brightness perception and scene preference in a controlled, windowless office environment. A two-interval-forced-choice experiment was conducted with the 20 lighting scenes derived from five CCTs (2500–10 000 K) and four luminances (12–120 cd/m²). The results from 20 observers showed that a higher wall luminance significantly increased brightness. At equal luminances, different CCT values had no significant effect on brightness, consistent with some reports that CCT is not a reliable predictor of brightness when other photometric factors are held constant. Scene preference increased as wall luminance increased to approximately 72 cd/m², but a further increase in wall luminance to 120 cd/m² had no significant impact on preference. As the CCT increased from 2500 K, the preference increased up to approximately 4000 K, followed by a substantial decline from 5715 to 10 000 K.
Electromagnetic wave absorbing and bending properties of 3D gradient structured woven composites: experiment and simulation
Authors: Yao Wenbin , Zhang Huawei , Zhou Xinghai , Gao Yuan , Wu Liwei , Lyu Lihua
Published: February 2023

In order to prepare 3D structural composites with electromagnetic wave absorption and load-bearing, 3D gradient structured woven fabrics were woven with basalt fiber filament yarn and carbon fiber filament yarn as raw materials on a common loom with rational design. After that, the three-dimensional gradient structured woven fabric was used as the reinforcing material, epoxy resin was used as the matrix, and carbonyl iron powder (CIP) and carbon black (CB), the electromagnetic wave absorbers, were added. In this paper, a vacuum-assisted resin transfer molding method was used to fabricate composite materials with three-dimensional structures. Finally, the experimental and simulation analysis techniques were used to analyze the absorbing and mechanical properties of the 3D gradient structured woven composites. The results show that the error value of the peak reflection loss is 10.6% in the simulation of electromagnetic wave absorption performance, and the error value of the maximum bending load is 2.37% in the simulation of mechanical performance. The theoretical simulation results and experimental results were in good agreement, which proved the validity of the electromagnetic wave absorbing model and finite element model. The experimental and simulation analyses revealed the material’s electromagnetic wave absorbing mechanism and bending damage mechanism and provided some theoretical guidance for designing 3D gradient structured woven composites with integrated load-bearing and electromagnetic wave absorbing functions.
Fat Asses, Weight Gain, and the White Feminine Commodification (Contortion) of Black Female Bounty
Authors: Alexander Bryant Keith
Published: February 2023

This short performative essay reflects on the author’s Black mother teaching him about cultural critique, particularly as this relates to the social construction of the Black female body. The author structures his reflections and lessons learned through the construct of fat asses, weight gain, and the White feminine commodification (contortion) of Black female bounty. He uses contemporary exemplars to reinforce aspects of his mother’s lived experience as a Black woman with a full body.
Correlation Between Indocyanine Green Fluorescence Patterns and Grade of Differentiation of Hepatocellular Carcinoma: A Western Prospective Cohort Study
Authors: Piccolo Gaetano , Barabino Matteo , Santambrogio Roberto , Lecchi Francesca , Di Gioia Giulio , Opocher Enrico , Bianchi Paolo Pietro
Published: February 2023

Background. Most of the available evidence on the use of indocyanine green (ICG) fluorescence in clinical practice consists of articles published by surgeons of the Asian-Pacific area. We performed a prospective cohort study to assess the patterns of ICG fluorescence in Western hepatocellular carcinoma (HCC) counterparts.

Methods. From April 2019 to January 2022, a total of 31 consecutive patients who underwent laparoscopic liver resection (LLR) for superficial HCC were enrolled in this prospective study. All patients underwent laparoscopic staging with both laparoscopic ultrasound (LUS) and ICG fluorescence imaging.

Results. A total of 38 hepatocellular carcinomas (HCCs) were enrolled: 23 superficial (surfacing at the liver’s Glissonian capsule), 5 exophytic, 5 shallow (<8 mm from the hepatic surface) and 5 deep (>10 mm from the hepatic surface). The detection rate with preoperative imaging (abdominal CT/MRI), LUS, ICG fluorescence and combined modalities (ICG and LUS) was 97.4%, 94.9%, 89.7% and 100%, respectively. The five deep seated lesions underwent ultrasound-guided laparoscopic thermal ablation. The other 33 HCCs were treated with minimally invasive liver resection. Intraoperative ultrasound patterns were registered for each single nodule resected. The ICG fluorescence pattern was classified in two types: total fluorescence (all the tumoral tissue showed strong and homogeneous fluorescence), n = 9/33 (27.3%), and non-total fluorescence (partial and rim fluorescence), n = 24/33 (72.7%). There was a statistical correlation between ICG patterns and grade of differentiation. Almost all lesions with uniform fluorescence pattern were well-differentiated HCCs (G1-G2), while partial and rim-type fluorescence pattern were more common among moderately and poorly differentiated HCCs (G3-G4) (88.9% vs 11.1%, 37.5% vs 62.5%, P = .025, respectively).

Conclusions. ICG fluorescence imaging could be used to identify early the grade of HCC, ie intraoperatively, thus influencing the intraoperative treatment.
Recent advances in piezoelectric textile materials: A brief literature review
Authors: Maestri Gabriela , Ferreira Ludimilla B , Bachmann Pedro , Paim Ana AM , Merlini Claudia , Steffens Fernanda
Published: February 2023

Smart textiles (ST) can be defined as materials capable of detecting an external stimulus, responding, and adapting its behavior according to the stimulus obtained. The field of study and development of these materials is extensive, and ST can be seen in areas such as health, transport, security, civil construction, and sports. Piezoelectric textiles are part of the ST category and are characterized due the ability to generate electrical energy from mechanical stimulus, and vice versa. Therefore, the main objective of this review is to present the current research on piezoelectric ST. In addition, the study highlights the process of obtaining materials with piezoelectric properties and the challenges and limitations, seeking to understand the contribution of the development of these materials in the field of wearable electronic devices. Thus, the main challenge in developing piezoelectric textiles is in the ability to supply energy to electronic devices to be applied in various fields such as motion detection, acoustics, impact absorption, among others. Moreover, piezoelectric ST is remarkably promising for the development of wearable electronic textiles (e-textiles) that consequently impact the creation of new functional materials that enable renewable sources to offer a positive contribution in the daily society.
Predicting adjustment of international students: The role of cultural intelligence and perceived cultural distance
Authors: Malay Elok D. , Otten Sabine , Coelen Robert J.
Published: February 2023

Despite years of investigation on international students’ adjustment, cultural distance and cultural intelligence, the definitions of and the relationship between these concepts are not yet sufficiently well established. This article further explores the three concepts and their possible interrelations. We propose a hypothesized model that considers subjectively perceived cultural distance (PCD) a variable of specific importance, and wherein we assume that the relationship between PCD and international students’ adjustment is moderated by students’ cultural intelligence (CQ). Our model aims to better explain the dynamics between these variables; it posits that students’ CQ level will affect whether and how PCD may influence international students’ psychological, sociocultural and academic adjustment in the host country. Consequently, the model offers several implications for future research and possible interventions to support international students’ adjustment in higher education.