bluuebunny/crossref_metadata_2025 huggingface dataset:
Pattern of statin use in several Hospitals in Jakarta. A cross sectional study
Authors: Simatupang Abraham , Irianto Adenan , Simanjuntak Waldemar , Panggabean Sahala
Published: December 2023

A preliminary, cross-sectional study on the pattern of statins use in three hospitals in Jakarta was conducted to see the responder rate of the patients who took statins. Data were taken from the Medical Records from May-July 2004 of each hospital. The inclusion criteria were outpatients diagnosed with dyslipidemia treated with statins either as first choice or add-on therapy to the other lipid-lowering drugs given. Two hundred and forty three cases were recorded during the 3-month period of examination, 127 male and 116 female. The average age of both group of patients were 56 ± 12 years (male) and 55 ± 12 years (female). The most commonly used statins as first choice and as add-on was atorvastatin (38.1%, and 1.6%, respectively), followed by rosuvastatin (20.5%), fluvastatin (11.5%), pravastatin (10.7%); whereas lovastatin (0.4%) and simvastatin (3.7%) were least prescribed. Patients’ total cholesterol levels were reduced significantly (241 ± 57 vs 207 ± 38 mg/dL, p less than 0.0001), whereas triglyceride levels were not significantly reduced (174 ± 86 vs 160 ± 71 mg/dL). Around 46% cases (72 out of 243 cases) met the NCEP ATP III goals on total cholesterol level. The most common combinations used, with respect to atorvastatin, were fenofibrate (11.3%), pravastatin (9.3%), rosuvastatin (3%), gemfibrozil (2%), whereas, with regard to rosuvastati, were gemfibrozil (9%), ciprofibrate (5%), and atorvastatin (3%). Large numbers of patients were not regularly checked up or low in compliance. In conclusion, statins usage in some hospitals in Jakarta had been inappropriately used, due to multiple factors, such as, prescribers, patients’ aspects, and the national health system. Therefore, in order to observe the efficacy of statins in clinical setting, a large scale study on the pattern of statin use should be conducted.
Physical exercise and quality of life in patients with cardiac disease
Authors: Wungouw Herlina
Published: December 2023

Good quality of life (QoL) that includes physical function, mental and social functions is important for everyone. However, in human life, many things can affect QoL, such as physical and psychological impairments. The prevalent psychological impairments in cardiac patients are anxiety and depression. To overcome these impairments, comprehensive approaches need to be applied to enhance QoL of people, especially those who suffer from chronic diseases, such as cardiac survivors. Exercise rehabilitation, such as aerobic and resistance training, is one of the proper approaches to help cardiac patients overcoming the psychological deficit that accompanies cardiac diseases. It can reduce the level of anxiety and depression, reduce muscle tension, make the patient feel more relaxed, increase confidence and self-esteem in daily life. Physically, exercise contributes to the increase of maximum oxygen consumption, flexibility, strength and endurance of these patients. Training can maintain and enhance physical activity, ability to work and psychological well-being. All together, they are important factors determining the QoL.
Protein kelompok BCl-2 sebagai target senyawa antikanker
Authors: Rumiyati Rumiyati
Published: December 2023

Recently, the mortality rate due to cancer has been increasing. This fact and the problem of cancer treatment in particular encourages the exploration of new alternative anticancer drugs from natural resources. The discovery of the new drugs requires explanation on their targets and mechanism of action. So far, in addition to alteration in the expression of proteins regulating apoptosis, some cancers demonstrate the presence of mutations in the tumor suppressor genes such as p53. These abnormalities would result in the destruction of apoptosis. Among targets of anticancer drugs through the modulation of apoptosis are BCl-2 family proteins which are able to release cytochrome c necessary for caspase activation. Anticancer drugs can stimulate the modulation of apoptosis on BCl-2 family targets by the modulation of oncogenes that can enhance the expession of tumor supressor genes which in turn influence the expression of pro-apoptosis or anti-apoptosis proteins.
Peran biologis Uncoupling Protein 2 (UCP2) pada obesitas dan diabetes mellitus tipe 2 (DMT2)
Authors: Susmiarsih Tripanjiasih
Published: December 2023

Obesity is a symptom or disorder determined by the interaction of several environmental and genetic factors. It is a result of imbalance between energy intake and expenditure. It is also suggested that obesity increases the risk of Type 2 Diabetes Mellitus (T2DM). It has been reported that uncoupling protein 2 (UCP2) may influence the susceptibility to obesity and T2DM. The aims of this literature study is to elucidate the biological role of UCP2 in obesity and T2DM. UCP2 is a transporter of the mitochondrial inner membrane that can uncouple proton production from mitochondrial respiration, thereby dissipating energy as heat and affecting energy expenditure. UCP2 acts as a proton carrier activated by free fatty acids. Obesity and fasting can elevate plasma fatty acids. High plasma fatty acid levels can increase UCP2 mRNA levels suggesting the role of these protein in the metabolic adaptation to obesity and fasting. Moreover, UCP2 plays a role as a negative regulator of insulin secretion. In pancreatic beta cells the ratio of ATP/ADP is key signal for insulin release. Therefore, increase UCP2 expression, as seen in the pancreatic beta cell, might cause a decrease in intracellular ATP and results in the impairment of insulin secretion, which causes diabetes. Ala55Val allele of UCP2 gene, as single nucleotide polymorphisms (SNPs) may influence the susceptibility to obesity and T2DM. However, the association of this allele to obesity and diabetes is different in various populations
Peranan Bidan Desa dalam menangani dan merujuk kasus bayi baru lahir asfiksia di Kabupaten Cirebon
Authors: Umniyati Helwiah
Published: December 2023

Each year 3 million newborns die during the first seven days of life, accounting for 75% of all neonatal deaths. At least 1 million babies die during their first 24 hours of life. Three major causes of neonatal death are infections (pneumonia, diarrhea, and tetanus) 36%, preterm birth 28% and asphyxia 23%. Causes of death vary between the early and late neonatal periods, with deaths caused by preterm birth, asphyxia and congenital defects occur predominantly during the frst week of life and infection is the major cause of neonatal deaths thereafter. In Indonesia based on 2001 Household Health Survey (SKRT 2001) neonatal death caused by asphyxia was 27% which was the second cause of neonatal death after low birth weight. The objective of this study was to learn the role of midwives in handling and referring birth asphyxia in Cirebon District by using qualitative method. The result showed that many people living in villages in Cirebon district did not understand the causes of asphyxia. They thought that babies could not cry because of bad spirit or devil. The midewives were capable of handling the asphyxia babies according to their knowledges obtained from training about asphyxia management. Sometimes however, the midwives encountered some constrains in practice such as low birth weight babies (only 1,4 Kg) and oversize concave cover for resuscitation. Other limiting factors occurred when the midwives would like to refer the babies to the hospital. The families might refuse with some reasons such as, no trust in the medical staff, shortage of money or difficulty in finding transportation.  Lack of incubator in the hospital was also another obstacle.
Faktor risiko penyakit degeneratif pada usia lanjut sedenter: studi kasus pada perempuan usia lanjut di Panti Wreda Khusnul Khotimah, Tangerang
Authors: Mukhtar Diniwati
Published: December 2023

Prevalence of degenerative diseases in the elderly is currently increasing worldwide due to several factors, such as structural and metabolic distortion, gender and physical activity. In Indonesia, as the life expectancy of the people tend to extend, the proportion of the elderly also increases over time, with various consequences. The present study aims to determine the risk for degenerative diseases among the elderly women residing in a nursing home in Tangerang District, Banten Province, Indonesia. The study was conducted using a descriptive case study design, involving anthropometric as well as blood examinations of the subject, and questionnaire pertaining age and family status, educational background and the length of stay in the nursing home. Results indicated that the mean of age of the subjects was 70 ± 6.4 years. The anthropometric measurement demonstrated a high prevalence of subjects with waist-to hip ratio of 0,89 ± 0,04 although the BMI risk was only noted in 45% of the subjects. The blood chemistry analysis indicated that the majority of the subjects had a high total cholesterol and low HDL cholesterol blood level, whereas the other components were relatively normal. The findings indicated that the reduced physical activity may contribute to the atherosclerosis risk factor as well as other degenerative diseases.
Konsumsi pangan dan status gizi pada penduduk asli di Kalimantan Timur: Pendekatan sosial-budaya, dan ekonomi
Authors: Suhaimi Ahmad
Published: December 2023

This study was aimed to examine food consumption and nutritional status in the household of indigenous people “Dayak” which resided at the low line of Mahakam river, and to conduct the study on social, culture, and economic factors which affected the food consumption. The result showed that average energy and protein consumption per person was 2.000,7 kcal and 71,0 gram which the actual energy consumption level was 100,04% and actual protein consumption level was 136,5%. The value of actual energy consumption level was in the good category ((>100% of RDA) and actual protein consumption level was in the good category (>100% of RDA). When the nutritional status of children under five was related to energy consumption level of household, the prevalence of malnutrition was in the low and deficit category and the good nutritional status tended to be in the sufficient and good category. The estimation was also supported by the Pearson Correlation of p=0.0001 and r=0.692. Highly significant relationship of nutritional status of children under five and the energy consumption level of household was observed. The socio-culture, economic factors which affected food consumption of household were: nutritional awareness of mother (p=0.016), food preference (p=0.023), food avoidance (p=0.000), inequality of member in the household (p=0.000), and income level of household (p=0.001).
The Effect of Calorie Restriction on Body Weight, Fat Tissue Weight and the Histopathological Picture of Fat Tissue in Rats
Authors: Fitriyana Lena , Mukhtar Diniwati , Royhan Aan
Published: December 2023

Background : Calorie restriction is a reduction in calorie intake without malnutrition, as the main tool to improve health (Tomiyama et al.,2017). Limitation of calorie intake around 20-40% of total calorie intake, but intake remains adequate to reduce inflammation (Trepanowski et al., 2010). Obesity is one of the consequences of excessive calorie consumption which causes inflammation so that it can increase the risk of degenerative diseases (Susantiningsih, 2015). Overweight is divided into two, namely hypertrophy occurs by the accumulation of large amounts of fat in unilocular fat cells, so that the size of fat cells reaches four times larger, but the number of fat cells does not increase. And hyperplasia is a heavy obesity because in addition to growing cells also the number of cells becomes more (Sunny Wangko, 2014). One effort that can be done to reduce the increase in degenerative diseases is by limiting caloric intake or appropriate calorie restriction (Brzek et al., 2012).Purpose : This study purpose to determine changes in body weight, fat tissue and histopathological features of fat tissue in rats given calorie restriction and reviewed according to Islamic views.Methods : This type of research is an experimental laboratory for 6 weeks with research subjects male white rats (Wistar Strain) which is divided into 2 groups, namely control, and Calorie Restrictions Taking samples of body weight and fat tissue in the abdomen and supraclavicular to see the number of cells fat, fat cell size and weight of white fat tissue and brown fat tissue.Results : Calorie restriction can reduce fat cell size, and weight of white fat tissue significantly (p <0.05). in brown fat there was a significant increase. but in the measurement of body weight and fat cell numbers there were no significant differences (p> 0.05).Conclusion :  In calorie restriction there was no significant relationship after a study of body weight and fat cell count, but found a significant relationship to the weight of white fat tissue and brown fat tissue and the size of fat cells. In Islamic view calorie restriction is the same as limiting food intake as recommended by the Prophet about 1/3 of the stomach for food.
Hubungan Usia dan Pendapatan dengan Kadar Iodium Urine Petani Wanita di Kabupaten Pandeglang
Authors: Salsabilla Dwi Alma , Mardhiyah Dian
Published: December 2023

Iodium merupakan komponen penting dari hormon tiroid. Penentuan status iodium dapat dilakukan melalui Ekskresi Iodium Urine (EIU). Gangguan akibat ketidakseimbangan iodium dalam tubuh dapat menyebabkan pembesaran kelenjar tiroid, hipotiroid, gangguan mental dan tirotoksikosis. Tujuan dari penelitian ini yaitu untuk mengetahui hubungan usia dan pendapatan dengan kadar iodium urine petani wanita di desa Pakuluran dan desa Setrajaya. Jenis penelitian yang digunakan dalam penelitian ini adalah deskriptif analitik dengan rancangan penelitian cross sectional. Populasinya adalah seluruh wanita yang bekerja sebagai petani atau buruh tani yang tinggal di desa Pakuluran sebanyak 62 orang dan desa Setrajaya sebanyak 53 orang dengan sampel yang diambil sebanyak 72 orang menggunakan teknik total sampling. Penelitian ini ditemukan bahwa petani wanita dengan kadar iodium urine tidak normal sebanyak 43 orang (59,7%) dan tidak ditemukan adanya perbedaan bermakna antara usia dan pendapatan dengan kadar iodium urine pada petani wanita tetapi ditemukan kadar iodium urine yang lebih tinggi pada petani wanita dengan pendapatan cukup dan pada usia kategori dewasa awal. Kadar iodium urine dapat dipengaruhi dari konsumsi makanan. Perlu adanya edukasi tentang makanan yang tinggi iodium seperti ikan, kerang-kerangan, rumput laut dan lain-lain agar dapat dihindari kadar iodium urine yang tinggi.
The Role of ZFH-04269, Pilicides ec240, and Mannosides as FimH Adhesins Inhibitor of Uropathogenic Escherichia coli (UPEC) and Multiplex Real-Time PCR as a Potential Method in Diagnosing Urinary Tract Infections
Authors: Ivan Ignatius , Sudharta Harvey , Widjanarko Nicolas Daniel , Stella Maureen Miracle , Tandarto Kevin , Santosa Mariani
Published: December 2023

Urinary tract infections (UTIs) can be difficult to diagnose and therefore a quicker and cheaper method but still having a high reliability result is needed. Multiplex real-time PCR can diagnose UTI better, as it has a high accuracy and time-efficiency. In other hand, as many infection is caused by bacterial attachment to cells, anti-adhesion therapeutics can be an option for treatment methods. Our objective is to analyse whether real-time multiplex PCR and anti-adhesive therapeutics can become the best methods for diagnosis and treatment options respectively. Results showed that it is feasible to identify uropathogens with more than 90% accuracy by using multiplex real-time PCR; while modified isoquinolone-mannoside is proved to have the highest FimH affinity and potency of any antagonists reported to date. Finally, we conclude that multiplex real-time PCR and the use of ZFH-04269, pilicides ec240, and mannosides as FimH adhesins inhibitor might be applicable as novel diagnostic method and treatment for UTIs.
Pengaruh Polusi Udara Terhadap Berat Badan, Berat Jaringan Lemak Dan Gambaran Histopatologi Jaringan Lemak Pada Tikus
Authors: Irwansyah Febri , Mukhtar Diniwati , Zuhroni Zuhroni , Royhan Aan
Published: December 2023

Latar Belakang : Obesitas dapat meningkatkan resiko berbagai macam penyakit vaskuler. Polusi udara dapat mempengaruhi regulasi hormon yang mengatur nafsu makan dan metabolisme energi melalui berbagai mekanisme aksi. Mekanisme ini menyebabkan ekspansi jaringan lemak berupa hipertrofi dan hiperplasi sel lemak yang menyebabkan peningkatan berat badan. Dalam pandangan Islam obesitas merupakan hal yang tidak dianjurkan, bahkan tidak disukai oleh Allah dan Rasul-Nya.Tujuan : Penelitian ini bertujuan untuk mengetahui perubahan berat badan, jaringan lemak dan gambaran histopatologi jaringan lemak pada tikus yang diberi paparan polusi udara dan ditinjau menurut pandangan islam.Metode : Jenis penelitian yang dilakukan adalah eksperimental laboratorium selama 6 minggu dengan subjek penelitian tikus putih jantan (Rattus norvegicus) yang dibagi ke dalam 2 kelompok, yaitu kontrol dan paparan polusi udara. Pengambilan sampel berat badan dan jaringan lemak pada bagian abdomen dan supraklavikula untuk melihat jumlah sel lemak, ukuran sel lemak dan berat jaringan lemak putih dan jaringan lemak coklat. Hasil : Paparan polusi udara dapat meningkatkan ukuran sel lemak, jumlah sel lemak dan berat jaringan lemak putih dan coklat secara signifikan (p<0.05). Tetapi pada pengukuran berat badan, tidak didapatkan perbedaan yang bermakna (p>0,05). Kesimpulan : Paparan polusi udara dapat meningkatkan diameter sel lemak putih, jumlah sel lemak putih, dan berat jaringan lemak putih dan lemak coklat secara signifikan. Tetapi paparan polusi udara tidak memberikan pengaruh yang berarti terhadap berat badan tikus.
Gut Microbiota in Stunted Children
Authors: Hervina Hervina , Ernawati Kadek Lusi , Astuti Ni Kadek Ari
Published: December 2023

Stunting is a condition of failure to thrive in children under five which is characterized by a lack of height compared to other children of their age. Although there was a decrease in the proportion of stunting from 37.2% in 2013 to 30.8% in 2018, this figure is still far from the target of  WHO, which is 20%. In stunted children, there is a change in the intestinal microbiota which causes disruption of nutrient absorption, leading to malnutrition. The microbiota in healthy children contains many probiotic species such as Bifidobacterium longum and Lactobacillus mucosae, while in stunted children there are many inflammogenic taxa such as the genus Desulfovibrio. the order of Campylobacterales, E. coli, Firmicutes, Proteobacteria, and Bacterioides.
Improving Students’ Vocabulary Mastery through Fun Thinkers Media
Authors: Sianturi Melisa Carolina , Tampubolon Sahlan , Manurung Lastri W.
Published: December 2023

This research examines the vocabulary knowledge abilities of autistic students in English subjects at SMP Negeri 3 Hutabayuraja. According to Zuchdi (1995: 3-7) vocabulary mastery is a person's ability to recognize, understand and use words well and correctly by listening, speaking, reading and writing.The research's formulation of the issue is "Does vocabulary knowledge skills be improved through Fun Thinkers media for the first year Autistic students of SMP Negeri 3 Hutabayuraja". The purpose of the current research is to ascertain whether linguistic abilities among autistic pupils have increased as a result of exposure to Playful Philosophers materials. The method of gathering information is being tested. Five autistic children in class VII at SMP Negeri 3 Hutabayuraja served as the study's participants. This research uses an experimental method, namely using Single Subject Research (SSR) with an AB design. The usage of Fun Thinkers media can enhance vocabulary knowledge abilities for the first-year Autistic students at SMP Negeri 3 Hutabayuraja, according to the findings of the data analysis and.discussion above. It.can be seen that.the.provision of interventions in.the form.of Vocabulary Learning through fun thinkers’ media shows an increase in scores for RH students and the improvement obtained is quite good.
Resacralizing Nature in Moya Cannon’s Poetry
Authors: Pietrzak Wit
Published: December 2023

The essay focuses on the idea of sacrality as it manifests itself in the poetry of Moya Cannon. It is argued that her poems espouse an ecocentric ethic through fostering a sense of nature's sacredness that is, however, by no means limited to a monotheistic view such as that promoted by Christianity. Instead, the sacred that Cannon explores in her work is characterized by an acceptance of a plurality of practices of piety and an attitude of wonder at the mysterious grace of nature, even in its most minute manifestations.
‘Irishmen could suffer in spirit with Spain’: Mairin Mitchell’s Storm over Spain, Ireland, and the Spanish Civil War
Authors: Peral Germán Asensio , Fernández Sánchez José Francisco
Published: December 2023

Storm over Spain (1937), by Mairin Mitchell, is a rare case in the bibliography of the Irish in the Spanish Civil War. This travelogue, which narrates the journey of the author around Andalusia in the months before the beginning of the conflict, has received scant critical attention by historians, literary critics and cultural analysts working on Irish and Hispanic Studies, despite offering a first-hand account of the atmosphere of tension and fear that preceded the Spanish Civil War. This essay pays attention to her book Storm over Spain with the aim of reassessing its merits as a powerful narrative, as a reliable source of information on the Spanish Civil War, and as an example of the pervasive influence of Irish history as a methodological approach to explain social structures in other cultures. In particular, it examines Mitchell's position on the Spanish conflict in the travelogue by looking at her discussion of a number of events and atrocities that took place during the war.
Yeats’s Faustian Meditations: Jung, Yoga, and The Secret of the Golden Flower
Authors: Murray Chris
Published: December 2023

W. B. Yeats's long-term interest in meditation practices gained new impetus in 1931 when he obtained a copy of The Secret of the Golden Flower, a Daoist manual translated from Chinese. Alongside detailed instructions on meditation, this book includes a commentary by C. G. Jung. Taking Faust as a model for the Western psyche, Jung cautions that Asian meditation techniques are unsuitable for Europeans. Yeats responds to Jung in his introduction to another translation, Patanjali's Aphorisms of Yoga (1938). Here Yeats adopts Faust as a paradigm for the meditating subject and equates Goethe's Faust with Buddhist and Hindu processes of enlightenment. Late poems such as ‘Mohini Chatterjee’, ‘The Circus Animals’ Desertion’, and ‘The Statues’ contain evidence that Yeats came to see an earlier project, Unity of Culture, as a quest for collective, national enlightenment. Thus, Yeats's regret at acquiring authoritative guidance on meditation so late in life indicates not only his wish to experiment with the discipline, but also that he understood meditation as a practice that would have advanced his plans for Ireland's self-realization.
Roadways of Fire: Cosmopolitan Critics and Modern Gas Lighting in W. B. Yeats’s John Sherman (1891)
Authors: Botham Peter Bland
Published: December 2023

This article argues that W. B. Yeats uses his early novel John Sherman (1891) to identify and interrogate a non-national model of poetry he newly conceived to be global in its significance. Previously Yeats had attacked Ireland's ‘West Britons’ for seeking to emulate the Anglocentric critical standards set by Matthew Arnold, and so ignoring the beauty and truths of their supposedly provincial homeland. Such art of the ‘critical’ rather than ‘creative imagination’, as typified for Yeats by the minor English poet William Watson, is dramatized in the overaestheticized meditations of the character William Howard from John Sherman. As Howard's ruminations on the Irish landscape proceed, however, his critical spirit develops from the cautious, Anglocentric anti-nativism of Watson's Arnoldian ‘scholar poet’ into the iconoclasm of Oscar Wilde's critic-artist. More radical in his intellectual ambitions and truly extra-national in his affiliations, Howard is galvanized to adopt this new, cosmopolitan attitude by the dispersed forces of technological modernization that had reached Ireland's western seaboard. In reaction to the all-pervasive urban lighting that stimulates Howard's worldly reflections, Yeats's gaze turns inward in the novel's poetic counterpart, seeking to locate the grounds of the Irish creative imagination in the occult dark of Innisfree.
Migración por amenidades en la ruralidad de América Latina
Authors: Millán-Otero Katy Luz , Torrejón Cardona Eryka Yuvelyre
Published: December 2023

Amenity migration demonstrates a conscious desire to migrate to rural areas, in most casesinfluenced by the attraction of natural or cultural comforts. The objectiveof this articleisto examine research trends on amenity migration in rural areas, metropolitan rural areas, and intermediate cities in Latin America. The methodconsisted ofa qualitative design framed within a state-of-the-art review. In the results,the different conceptual terms used to describe this phenomenonare detailed,the Latin American countries where these migratory flows occuraregeoreferenced,and the theoretical and methodological approaches of the studies are also expanded upon. The discussionhighlights the gaps in current research and the challenges for studying these new human mobilities.
Literary topoi in today’s music as a bridge to the classics Spanish authors
Authors: Cristobal Hornillos Rubén , Villanueva Roa Juan de Dios
Published: December 2023

This article presents a review of literary topoi in current music that come from classical Spanish authors and that, therefore, can be exploited didactically with the aim of bringing students closer to literature. The songs that young people listen to are a "powerful hook" with the literary tradition since they allow them to identify these topics and connect them with classic literary works. From a theoretical point of view, we begin by delving into the links between literature and music, we by addressing the concept of literary topic, and we conclude by connecting some current songs with classic literary works through some literary topics or catchwords. These approaches were subjected to classroom action research that was initiated in the framework of a doctoral dissertation and implemented in a Warsaw secondary school mainly during the 2013/2014 academic year. It was subsequently adapted for interactive use within an innovation project of the University of Zaragoza in the 2017/18 academic year and finally applied in an innovation project of the Government of Aragon with 3rd ESO students of the IES Ramón Pignatelli during the 2018/19 academic year. Finally, we analyzed the results of the practical applications, which showed an increase in both student motivation and understanding of literary content.
Design and Analysis of a Battery Charging System for a Pico-Hydro Power Plant
Authors: Hidayat Mohammad Noor , Syauqiramadhan Naufal
Published: December 2023

Pico-Hydro Power Plant (PLTPH) is very dependent on the received water energy, therefore a storage medium is needed to store electrical energy by using a battery and DC-DC Buck Converter as a regulator of the output voltage of the generator to charging the battery. In addition, it is necessary to design equipment in battery charging system. At PLTPH to adjust the generator voltage using a DC-DC Buck Converter 30A with an input voltage rating of 20V-70V and an output voltage of 2.5V-50V can be set for charging the battery. The battery capacity of this PLTPH uses 4 VRLA 12V 100Ah batteries which are arranged in 2 series and 1 parallel so that the battery capacity becomes 24V 200Ah with a load of the main PPYD Al-Ikhlas building with 4.2kWh of energy consumed. In testing the performance of the battery the battery is in accordance with the characteristics of the battery and the voltage is inversely proportional to the current, while the DC-DC Buck Converter has a large efficiency of 85% which shows the performance of the DC-DC Buck Converter is very good
Sistem Monitoring Kelembaban Tanah dengan Sensor Soil Moisture Berbasis Internet of Things
Authors: Mahfud Faisal
Published: December 2023

Kondisi tanah daerah wajik cepat kering apabila tidak mendapat air yang cukup karena lahan yang bersifat terbuka maka diperlukan pemantauan secara berkala terhadap tanah untuk mendapat hasil panen yang maksimal. Penelitian ini  bertujuan untuk membuat dan merancang sistem monitoring  kelembaban tanah dengan sensor soil moisture berbasis website dan melakukan proses monitoring berdasarkan hasil sensor soil moisture. Metode yang digunakan merupakan metode rule base yaitu metode yang menggunakan rules sebagai representasi pengetahuan untuk diimplementasikan ke dalam suatu sistem yang dirancang, implementasi rule base diterapkan pada kondisi nilai sensor soil moisture untuk membaca kondisi kelembaban tanah. Hasil penelitian berupa sistem monitoring kelembaban tanah dengan pembacaan sensor soil moisture yang ditampilkan secara real time pada website dan notifikasi telegram dengan akurasi hasil yang bisa digunakan untuk memantau kondisi kelembaban tanah pada lahan untuk memperoleh hasil panen yang maksimal.
ddPCR provides a sensitive test compared with GeneXpert MTB/RIF and mNGS for suspected Mycobacterium tuberculosis infection
Authors: Zhang Dan , Yu Fei , Han Dongsheng , Chen Weizhen , Yuan Lingjun , Xie Mengxiao , Zheng Jieyuan , Wang Jingchao , Lou Bin , Zheng Shufa , Chen Yu
Published: December 2023

Introduction

The Metagenomics next-generation sequencing (mNGS) and GeneXpert MTB/RIF assay (Xpert) exhibited a sensitivity for tuberculosis (TB) diagnostic performance. Research that directly compared the clinical performance of ddPCR analysis, mNGS, and Xpert in mycobacterium tuberculosis complex (MTB) infection has not been conducted.

Methods

The study aimed to evaluate the diagnostic performance of ddPCR compared to mNGS and Xpert for the detection of MTB in multiple types of clinical samples. The final clinical diagnosis was used as the reference standard.

Results

Out of 236 patients with suspected active TB infection, 217 underwent synchronous testing for tuberculosis using ddPCR, Xpert, and mNGS on direct clinical samples. During follow-up, 100 out of 217 participants were diagnosed with MTB infection. Compared to the clinical final diagnosis, ddPCR produced the highest sensitivity of 99% compared with mNGS (86%) and Xpert (64%) for all active MTB cases.

Discussion

Twenty-two Xpert-negative samples were positive in mNGS tests, which confirmed the clinical diagnosis results from ddPCR and clinical manifestation, radiologic findings. Thirteen mNGS-negative samples were positive in ddPCR assays, which confirmed the clinical final diagnosis.ddPCR provides a higher sensitive compared to Xpert and mNGS for MTB diagnosis, as defined by the high concordance between ddPCR assay and clinical final diagnosis.
Influence of electrolyte imbalance on regional wall motion abnormalities in STEMI patients of North Indian origin
Authors: Shiraz Rizvi S. Mohd. , Sunny Sini , Wani Irshad A. , Mahdi Farzana , Zaidi Zeeshan H. , Rajasekaran Namakkal S.
Published: December 2023

Assessing regional wall motion abnormalities (RWMA) in the myocardium may provide early diagnosis and treat chronic remodeling in STEMI patients. We assessed RWMA in 217 subjects with anterior STEMI admitted to Era University Hospital in Lucknow, UP, India. Besides abnormalities in the LAD territory, sub-sets of patients exhibited diffuse regional myocardial dysfunction. Interestingly, variations in serum electrolytes, specifically sodium and potassium, significantly affected the distribution and frequency of RWMA. Notably, RWMA occurred in the basal septum, apical septum, apex, and lateral wall in the anterior STEMI group. Additionally, the rate of regional dysfunction varied with serum urea and creatinine levels. This suggests that anterior STEMI can manifest myocardial abnormalities beyond the LAD territory. These findings indicate that ST-segment elevation might not be specific, possibly influenced by electrolyte changes affecting cardiac rhythm. Therefore, diagnosing and correcting region-specific wall motion abnormalities and electrolyte imbalances may improve outcomes in STEMI patients.
Longitudinal outcomes of final kissing balloon inflation in coronary bifurcation lesions treated with a single stent
Authors: He Lefan , Robb John F. , Martinez-Camblor Pablo , Andrus Bruce W. , Greene Lily J. , Gongal Prajesh , Reddy Dhruthi S. , DeVries James T.
Published: December 2023

Background

Final kissing balloon inflation (FKBI) is a percutaneous coronary intervention (PCI) technique that is considered mandatory to improve outcomes in two-stent strategies, but its use in single-stent bifurcation PCI remains controversial.

Methods

In this retrospective cohort study, we identified patients with coronary bifurcation lesions treated with one stent from January 2012 to March 2021 at a single academic medical center. Incidence rates per 1,000 patient-years (IR1000) were calculated for the outcomes of all-cause mortality, myocardial infarction (MI), stent thrombosis (ST), target lesion revascularization (TLR), coronary artery bypass graft (CABG), and cardiac readmission between patients who received FKBI and those who did not over a median follow up of 2.3 years. Studied outcomes were adjusted for all baseline clinical and procedural characteristics.

Results

This study included 893 consecutive patients of which 256 received FKBI and 637 did not. The IR1000 for MI were 51.1 and 27.6 for patients who received FKBI and patients who did not, respectively (adjusted HR = 2.44, p = 0.001). The IR1000 for death were 31.2 and 52.3 for patients who received FKBI and patients who did not, respectively (adjusted HR = 0.68, p = 0.141). The incidence rates of ST, TLR, CABG, and cardiac readmissions were similar between patients who received FKBI and those who did not.

Conclusions

These results suggest that performing FKBI in a one-stent technique was associated with higher rates of myocardial infarction, particularly in the first 6 months, and no difference in death, ST, TLR, CABG, and cardiac readmission rates.
Case Report: SCN5A mutations in three young patients with sick sinus syndrome
Authors: Liang Jiayu , Luo Suxin , Huang Bi
Published: December 2023

Background

Sick Sinus Syndrome (SSS) is generally regarded as a degenerative disease with aging; however, genetic mutations have been confirmed to be associated with SSS. Among them, mutations in SCN5A are common in patients with SSS. We report three young SSS patients with SCN5A mutations at different sites that have not been previously reported in Asian patients.

Case presentation

The three patients were all young females who presented with symptoms of severe bradycardia and paroxysmal atrial flutter, for which two patients received ablation therapy. However, after ablation, Holter monitoring indicated a significant long cardiac arrest; therefore, the patients received pacemaker implantation. The three patients had familial SSS, and genetic testing was performed. Mutations were found in SCN5A at different sites in the three families. All three patients received pacemaker implantation, resulting in the symptoms of severe bradycardia disappearing.

Conclusion

SCN5A heterozygous mutations are common among patients clinically affected by SSS. Their causative role is confirmed by our data and by the co-occurrence of genetic arrhythmias among our patients. Genetic testing for SSS cannot be performed as a single gene panel because of feasible literature results, but in presence of familial and personal history of SSS in association with arrhythmias can provide clinically useful information.
The adverse effect of gestational diabetes mellitus and hypertensive disorders of pregnancy on maternal–perinatal outcomes among singleton and twin pregnancies: a retrospective cohort study (2011–2019)
Authors: Nawsherwan  , Liu Zhiyi , Le Zhang , Mubarik Sumaira , Sun Yanmei , Naeem Shafaq , Li Hui
Published: December 2023

Background

Gestational diabetes mellitus (GDM) and hypertensive disorders of pregnancy (HDP) are the predominant pregnancy complications among singleton and twin pregnancies worldwide. Our primary objective was to explore the adverse effect of GDM and HDP on maternal–perinatal outcomes compared with non-GDM and non-HDP in singleton and twin pregnancies. The secondary objective was to find the risk of adverse maternal–perinatal outcomes in twin pregnancies compared with singleton pregnancies complicated with GDM and HDP in Hubei, China.

Methods

A tertiary hospital-based retrospective study was conducted at Wuhan University Renmin Hospital, Hubei Province, China, from 2011 to 2019. A chi-square test was used to determine the difference in adverse maternal–perinatal outcomes between singleton and twin pregnancies. A multiple binary logistic regression model and a joinpoint regression model were used to determine the association of GDM and HDP with adverse maternal–perinatal outcomes and GDM and HDP temporal trend among singleton and twin pregnancies.

Results

The trend of HDP [average annual percentage change (AAPC) 15.1% (95% confidence interval (95%CI): 5.3, 25.7)] among singleton pregnancies and GDM [AAPC 50.4% (95%CI: 19.9, 88.7)] among twin pregnancies significantly increased from 2011 to 2019. After adjusting for confounding factors, GDM is associated with an increased risk of C-section (adjusted odds ratio (aOR), 1.5; 95%CI: 1.3, 1.6) and macrosomia (aOR, 1.3; 95%CI: 1.1, 1.6) in singleton and preterm birth (PTB) (aOR, 2.1; 95%CI: 1.2, 3.3) in twin pregnancies compared with non-GDM. HDP was associated with a higher risk of C-section, PTB, perinatal mortality, and low birth weight (LBW) in both singleton and twin pregnancies compared with the non-HDP. Compared with singleton pregnancies complicated with GDM and HDP, twin pregnancies showed higher odds of C-section [(aOR, 1.7; 95%CI: 1.1, 2.7), (aOR, 4.6; 95%CI: 2.5, 8.7), respectively], PTB [(aOR, 22.9; 95%CI: 14.1, 37.3), (aOR, 8.1; 95%CI: 5.3, 12.3), respectively], LBW [(aOR, 12.1; 95%CI: 8.2, 18.1), (aOR, 5.1; 95%CI: 3.6, 7.4), respectively], and low Apgar score [(aOR, 8.2; 95%CI: 4.4, 15.1), (aOR, 3.8; 95%CI: 2.4, 5.8), respectively] complicated with GDM and HDP.

Conclusion

In conclusion, GDM showed an increased risk of a few adverse maternal–perinatal outcomes and HDP is associated with a higher risk of several adverse maternal–perinatal outcomes in singleton and twin pregnancies compared to non-GDM and non-HDP. Moreover, twin pregnancies complicated with GDM and HDP showed higher odds of adverse maternal–neonatal outcomes compared with singleton pregnancies complicated with GDM and HDP.
The impact of farm household tourism operations on poverty reduction and conservation under the control policies of China’s protected areas
Authors: He Dan , Wang Jingwen , Liu Xiang , Shi Xiaoliang , Xu Zhe , Wang Yang , Qiu Yingying , Chen Ke
Published: December 2023

Against the global trend of increasing multiple participants involvement in protected areas management, the Chinese government has implemented a series of stricter policies since 2015. Tourism is an important alternative livelihood for farmers near protected areas. Based on survey data from 1,028 households in six protected areas, this study uses the propensity score matching (PSM) method to empirically examine the change effects of poverty reduction and conservation of farmers engaged in tourism under the influence of protected areas tourism management policies. The PSM method reduces sample self-selection bias and improves the accuracy of research conclusions. The findings reveal that irrespective of whether the areas are subjected to regulatory policies or not, tourism operations are significantly and inversely correlated with households’ multidimensional poverty index, and are notably positively correlated with their comprehensive conservation index. Consequently, tourism operations exhibit substantial poverty alleviation and protective effects. However, the current suite of protected areas control policies has curtailed the sustainable growth of tourism within these areas, resulting in 9.64% decrease in poverty alleviation effects and 10.33% decrease in protective effects derived from tourism operations. Despite their restrictive impacts on tourism, these policies have yielded some positive outcomes, fostering social equity within protected areas and catalyzing the transition from traditional livelihoods. Drawing upon these empirical findings, this study proposes recommendations and directions for fine-tuning China’s existing regulatory policies pertaining to tourism in protected areas.
How can we achieve more sustainable water allocation in water-deficient areas? A case study from China’s Fen River Basin
Authors: Li Chenchen , Wu Jianwei
Published: December 2023

Achieving the goal of water resource allocation improvement is significant for the ecological conservation of basins. Considering the water supply and demand contradiction and the competition among stakeholders within water-deficient regions, we developed a multi-objective optimization model and proposed the most effective method for allocating water resources based on the study of supply and demand. This study reveals the following findings: 1) the total demand for the Fen River Basin in 2030 will be 6.68 billion m3. Compared with previous years, the actual consumption has increased, but the growth rate has slowed down. 2) The basin’s total supply of water in 2030 will be 7.855 billion m3. With the tightening of the management practice, the consumption and supply in each county showed a decreasing trend year by year. 3) The results of optimal water allocation for 2030 indicate that the FRB should allocate 1.655 billion m3 for domestic water, 4.57 billion m3 for production consumption, and 57 million m3 for ecological use.
Case Report: Extraocular muscles paralysis associated with GAD65 antibody: a case series study
Authors: Zhang Heyu , Yue Jiajia , Lian Chun , Long Youming , He Dan
Published: December 2023

Objective

To explore the clinical manifestations of glutamic acid decarboxylase 65 (GAD65) antibody-positive patients with extraocular symptoms and the possible mechanism.

Method

Assays for the presence of GAD65 antibodies were performed on patients’ serum and cerebral spinal fluid (CSF). The brain and ocular structures involved in eye movement were assessed via magnetic resonance imaging (MRI). Tests such as electromyography (EMG), particularly repetitive nerve stimulation (RNS), and neostigmine tests were utilized for differential diagnosis. Additionally, the interaction of GAD65 antibodies with muscle tissue was confirmed using immunofluorescence techniques.

Result

Each patient exhibited symptoms akin to extraocular myasthenia gravis (MG), with two individuals reporting diplopia and two experiencing ptosis. GAD65 antibodies were detected in either the serum or CSF, which were shown to bind with monkey cerebellum slides and mouse muscle slides. Neuroimaging of the brain and extraocular muscles via MRI showed no abnormalities, and all patients tested negative for the neostigmine test, RNS via EMG, and the presence of MG antibodies. However, thyroid-related antibodies were found to be abnormal in four of the patients.

Conclusion

Our results showed that GAD65 antibodies are not only associated with encephalitis, cerebellum ataxia or stiff-person syndrome caused by the decrease of GABAergic transmission but also diplopia and ptosis. Therefore, we should pay more attention to extraocular muscle paralysis patients without pathogenic antibodies directed against the components of neuromuscular junctions.
Efficacy, safety, and survival of neoadjuvant immunochemotherapy in operable non-small cell lung cancer: a systematic review and meta-analysis
Authors: Zheng Yue , Feng Baijie , Chen Jingyao , You Liting
Published: December 2023

Background

Neoadjuvant immunochemotherapy may benefit patients with non-small cell lung cancer (NSCLC), but its impact requires further investigation.

Methods

A meta-analysis was conducted. PubMed, Embase, Web of Science, and the Cochrane Library were searched. The study was registered in PROSPERO (registration no. CRD42022360893).

Results

60 studies of 3,632 patients were included. Comparing with neoadjuvant chemotherapy, neoadjuvant immunochemotherapy showed higher pCR (RR: 4.71, 95% CI: 3.69, 6.02), MPR (RR, 3.20, 95% CI: 2.75, 3.74), and ORR (RR, 1.46, 95% CI: 1.21, 1.77), fewer surgical complications (RR: 0.67, 95%CI: 0.48, 0.94), higher R0 resection rate (RR: 1.06, 95%CI: 1.03, 1.10, I2 = 52%), and longer 1-year and 2-year OS, without affecting TRAEs. For neoadjuvant immunochemotherapy in NSCLC, the pooled pCR rate was 0.35 (95% CI: 0.31, 0.39), MPR was 0.59 (95% CI: 0.54, 0.63), and ORR was 0.71 (95% CI: 0.66, 0.76). The pooled incidence of all grade TRAEs was 0.70 (95% CI: 0.60, 0.81), and that of >= grade 3 TRAEs was 0.24 (95% CI: 0.16, 0.32). The surgical complications rate was 0.13 (95% CI: 0.07, 0.18) and R0 resection rate was 0.98 (95% CI: 0.96, 0.99). The pooled 1-year OS was 0.97 (95%CI: 0.96, 0.99), and 2-year OS was 0.89 (95%CI: 0.83, 0.94). Patients with squamous cell carcinoma, stage III or higher PD-L1 performed better. Notably, no significant differences were observed in pCR, MPR, and ORR between 2 or more treatment cycles. Pembrolizumab-, or toripalimab-based neoadjuvant immunochemotherapy demonstrated superior efficacy and tolerable toxicity.

Conclusion

According to our analysis, reliable efficacy, safety, and survival of neoadjuvant immunochemotherapy for operable NSCLC were demonstrated.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42022360893, identifier CRD42022360893.
De novo identification of bacterial antigens of a clinical isolate by combining use of proteosurfaceomics, secretomics, and BacScan technologies
Authors: Yang Jinyue , Zhang Xueting , Dong Junhua , Zhang Qian , Sun Erchao , Chen Cen , Miao Zhuangxia , Zheng Yifei , Zhang Nan , Tao Pan
Published: December 2023

Background

Emerging infectious diseases pose a significant threat to both human and animal populations. Rapid de novo identification of protective antigens from a clinical isolate and development of an antigen-matched vaccine is a golden strategy to prevent the spread of emerging novel pathogens.

Methods

Here, we focused on Actinobacillus pleuropneumoniae, which poses a serious threat to the pig industry, and developed a general workflow by integrating proteosurfaceomics, secretomics, and BacScan technologies for the rapid de novo identification of bacterial protective proteins from a clinical isolate.

Results

As a proof of concept, we identified 3 novel protective proteins of A. pleuropneumoniae. Using the protective protein HBS1_14 and toxin proteins, we have developed a promising multivalent subunit vaccine against A. pleuropneumoniae.

Discussion

We believe that our strategy can be applied to any bacterial pathogen and has the potential to significantly accelerate the development of antigen-matched vaccines to prevent the spread of an emerging novel bacterial pathogen.