bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Cost-Effectiveness of Trametinib Plus Dabrafenib as First-Line Therapy for Metastatic BRAF V600-Mutated Melanoma in China
Authors: Sun Guojun , Wang Jingwen , Zhou Xiaoying , Hu Zhichao , Dong Zuojun
Published: October 2021

Background: Treatment with trametinib plus dabrafenib for patients exhibiting metastatic BRAF V600-mutated melanoma has been approved in China.Method: We developed a Markov model to evaluate and compare the cost-effectiveness of trametinib plus dabrafenib against vemurafenib. Information on clinical situations, the rate of adverse reactions, follow-up treatments, and estimated transition probabilities were derived from the results of a clinical trial that compared treatment with trametinib plus dabrafenib against vemurafenib alone. A one-way sensitivity analysis and a probabilistic sensitivity analysis were conducted to assess the influence of uncertainty on the key model.Result: Treatment with trametinib plus dabrafenib for one patient in the treatment period was estimated to cost CNY 332 294, and yield a total gain of 16.6 quality-adjusted life years (QALYs). Compared with vemurafenib, treatment involving trametinib plus dabrafenib yielded additional 3.96 QALYs, resulting in a unit cost-effectiveness of CNY 27 460 per QALY. Sensitivity analysis shows that the results are reliable.Conclusion：From the perspective of China's health system, applying China's per-capita GDP in 2020 as the threshold of willingness-to-pay, it is cost-effective to treat metastatic melanoma patients exhibiting BRAF V600 mutation with dabrafenib plus trametinib.
Recurrent Malignant Peripheral Nerve Sheath Tumor Presenting As an Asymptomatic Intravenous Thrombus Extending to the Heart: A Case Report
Authors: Hirozane Toru , Nakayama Robert , Yamaguchi Sayaka , Mori Tomoaki , Asano Naofumi , Asakura Keisuke , Kikuta Kazutaka , Kawaida Miho , Sasaki Aya , Okita Hajime , Nakatsuka Seishi , Ito Tsutomu
Published: October 2021

Background: Malignant peripheral nerve sheath tumor (MPNST) is a rare soft tissue sarcoma mainly treated via surgical resection. Herein, we report a case of MPNST wherein a massive tumor thrombus extended to the major veins and heart.Case presentation: A 39-year-old female with a history of neurofibromatosis type 1 developed MPNST from the right radial nerve. In addition to adjuvant chemotherapy, she underwent wide tumor resection and concomitant radial nerve resection, followed by postoperative radiotherapy. Histological evaluation revealed marked venous invasion. The 2-year follow-up CT revealed an asymptomatic recurrent tumor thrombus extending from the right subclavian vein to the heart. An urgent life-saving operation was performed to ligate the base of the right subclavian vein and remove the entire intravenous thrombus that extended to the right ventricle. The remaining tumor in the right subclavian vein increased in size 3 months after thrombectomy. After confirming the absence of any metastatic lesions, the patient underwent extended forequarter amputation to achieve surgical remission. One year later, a new metastasis to the right diaphragm was safely resected. The patient remains alive without any evidence of disease 2 years after the extended forequarter amputation. Conclusions: In cases of a previous history of microscopic venous invasion, recurrence can occur as a massive tumor thrombus that extends to the great vessels.
Deep Learning Assisted Cognitive Diagnosis for the D-Riska Application
Authors: Cuerda Cristian , Zornoza Alejandro , Tesoriero Ricardo , Gallud Jose A. , Romero-Ayuso Dulce
Published: October 2021

In this article, we expose a system developed that extends the Acquired Brain Injury (ABI) diagnostic application known as D-Riska with an artificial intelligence module that supports the diagnosis of ABI enabling therapists to evaluate patients in an assisted way. The application is in charge of collecting the data of the diagnostic tests of the patients, and due to a multi-class. Convolutional Neural Network classifier (CNN), it is capable of making predictions that facilitate the diagnosis and the final score obtained in the test by the patient. To find out the best solution to this problem, different classifiers are used to compare the performance of the proposed model based on various classification metrics. The proposed CNN classifier makes predictions with 93 \% of Accuracy, 94 \% of Precision, 91 \%, of Recall and 92\% of F1-Score.
Differentiation of Malignant Salivary Gland Tumors from Pleomorphic Adenomas and Warthin’s Tumors: Combined Diagnostic Value of Tumor Blood Flow and Apparent Diffusion Coefficient by Histogram Analysis
Authors: Tanaka Fumine , Umino Maki , Maeda Masayuki , Nakayama Ryohei , Inoue Katsuhiro , Kogue Ryota , Obara Makoto , Sakuma Hajime
Published: October 2021

We aimed to evaluate the usefulness of tumor blood flow (TBF) obtained by pseudocontinuous arterial spin labeling (pCASL) and apparent diffusion coefficient (ADC) for differentiating salivary gland malignant tumors (MTs) from pleomorphic adenomas (PAs) and Warthin’s tumors (WTs). We used pCASL imaging and ADC map to evaluate 65 patients, including 16 with MT, 30 with PA, and 19 with WT. We evaluated all tumors by histogram analyses and compared various characteristics by one-way analysis of variance followed by Tukey post-hoc tests. Diagnostic performance was evaluated by receiver operating characteristic (ROC) curve analysis. There were significant differences in the mean, 50th, 75th, and 90th percentiles of TBF among the tumor types, in the mean TBFs (ml/100g/min) between MTs (57.47 ± 35.14) and PAs (29.88 ± 22.53, p = 0.039) and between MTs and WTs (119.31 ± 50.11, p < 0.001), as well as in the mean ADCs (×10− 3 mm2/sec) between MTs (1.08 ± 0.28) and PAs (1.60 ± 0.34, p < 0.001), but not in the mean ADCs between MTs and WTs (0.87 ± 0.23, p = 0.117). In the ROC curve analysis, the highest areas under the curves (AUCs) were achieved by the 10th and 25th percentiles of ADC (AUC = 0.885) for differentiating MTs from PAs and the 50th percentile of TBF (AUC = 0.855) for differentiating MTs from WTs. The AUCs of TBF, ADC, and combination of TBF and ADC were 0.850, 0.885, and 0.950 for MT and PA differentiation and 0.855, 0.814, and 0.905 for MT and WT differentiation, respectively. The combination of TBF and ADC evaluated by histogram analysis helped differentiate salivary gland MTs from PAs and WTs.
Magnetic Field Amplification Driven by the Gyro Motion of Charged Particles
Authors: Gu Yan-Jun , Murakami Masakatsu
Published: October 2021

Spontaneous magnetic field generation plays important role in laser-plasma interactions. Strong quasi-static magnetic fields affect the thermal conductivity and the plasma dynamics, particularly in the case of ultra intense laser where the magnetic part of Lorentz force becomes as significant as the electric part. Kinetic simulations of giga-gauss magnetic field amplification via a laser irradiated microtube structure reveal the dynamics of charged particle implosions and the mechanism of magnetic field growth. A giga-gauss magnetic field is generated and amplified with the opposite polarity to the seed magnetic field. The spot size of the field is comparable to the laser wavelength, and the lifetime is hundreds of femtoseconds. An analytical model is presented to explain the underlying physics. This study should aid in designing future experiments.
Impact of Different Waves of COVID-19 on Emergency Medical Services and Out-of-hospital Cardiopulmonary Arrest in Madrid, Spain
Authors: Navalpotro-Pascual Jose-María , Monge-Martín Diana , González-León Manuel-José , Neria Fernando , Peinado-Vallejo Francisco , Alonso-Blas Carlos , Muñoz-Isabel Belén , Muñecas-Cuesta Yago , Carrillo-Freire Alfredo , Les-González Juan , Mateos-Rodríguez Alonso
Published: October 2021

Background: COVID-19 has led to decreased survival of out-of-hospital cardiorespiratory arrest (OHCA). We analysed the impact of the first COVID-19 pandemic year on emergency medical services and OHCA care compared with the previous year.Methods: Data for this observational study were collected for OHCAs attended by the SUMMA 112 emergency service during March 2019 to March 2021. We compared data covering 15 March 2020–14 March 2021 (pandemic year) to retrospective data covering 15 March 2019–14 March 2020 (non-pandemic year). Results: During the pandemic period, 1743 OHCA patients were attended, compared to 1781 during the non-pandemic year. Median patient age during the pandemic period was lower than in the non-pandemic period (71 vs 72, p=0·037). Emergency services response activation time increased during the pandemic year, to 3 minutes, 16 seconds from 2 minutes, 48 seconds in the non-pandemic period (p=0·001). Time to arrival at the scene also increased during the pandemic (12 minutes vs 11 minutes, 25 seconds before the pandemic; p=0·001). The percentage of OHCAs in which resuscitation was attempted was lower during the pandemic (59·4% vs 62·9%, p=0·034), as were survival on hospital arrival (30·3% vs 34·6%, p=0·04). Differences in response activation time (p=0·003) and scene arrival times (p=0·003) were greater during the first pandemic wave compared with the later phases. Conclusions: The different phases of the pandemic variably affected OHCA care. The first wave led to longer resource activation, increased home events and scene arrival times, as well as lower patient survival.
Migration of aerobic bacteria from the duodenum to the pancreas with tumors: a mechanistic understanding
Authors: Shirai Hiroaki , Ito Cocoro , Tsukada Kosuke
Published: October 2021

More aerobic bacteria are found in the pancreas with tumors than in the healthy pancreas. We provide a mechanistic understanding of the migration of intestinal bacteria from the duodenum to the pancreas with tumors. Mathematical models of migration of aerobic bacteria from the duodenum to the pancreas with tumors in the hepatopancreatic duct were developed. In addition, the behaviors of GFP E. coli under a pH gradient in a microfluidic device were analyzed. Moreover, upstream migrations of Pseudomonas fluorescens against flow were measured in a polydimethylsiloxane (PDMS) T-shaped cylinder mimicking a pancreatic duct. The simulated bacterial concentration of the pancreas with tumors was higher than that of the healthy pancreas and agreed reasonably well with the literature. Migration of aerobic bacteria in the hepatopancreatic duct is counteracted by bile and pancreatic juice flow but facilitated greatly by bacterial pH taxis from lower pH in duodenum fluid toward slightly alkaline pH in pancreatic juice, favorable for them. Migration of bacteria to the pancreas with tumors is made easier by solid tumors on the pancreatic duct, which compresses the pancreatic duct and thus reduces the fluid flow rate. On the other hand, GFP E. coli migrated under the pH gradient in a microfluidic device from acidic areas toward neutral or slightly alkaline pH, validating pH taxis. Furthermore, Pseudomonas fluorescens migrated upstream from hydrochloride solution but not from bicarbonate solution against bicarbonate flow at >20 µm/s, with an advancing velocity of approximately 60 µm/s, validating the models (244 words).
No DC superheating and increased surface pinning in low temperature baked niobium
Authors: Turner Daniel Andrew , Burt Graeme , Junginger Tobias
Published: October 2021

Superconducting Radio-Frequency cavities are currently made out of niobium. Niobium cavities are limited by the magnetic field on the cavity walls due to the entry of vortices at the field of first vortex penetration, Hvp. Low temperature baking in vacuum or low pressure gas atmosphere removes the strong decrease of the quality factor with accelerating gradient (high field Q-slope). Some cavities reach surface magnetic field above the lower critical field, Hc1. One hypothesis for this performance increase is that the outer layer affected by the treatments acts as a barrier for vortex penetration (effective bilayer). Using a vibrating sample magnetometer the field of first flux penetration (Hvp) was measured for Nb ellipsoids with various low temperature treatments. All Hvp values were found to be consistent with the lower critical field, Hc1 , as predicted for clean niobium. This led to the conclusion that a metastable flux free state above Hc1 cannot be observed in DC magnetometry for low temperature baked niobium unlike for bilayers consisting of two superconductors as previously published. The effect of flux pinning differed significantly between treatments, suggesting that the high field Q-slope mitigation might be related to vortex pinning in the surface of the cavities.
Impact of Traffic Congestion on Spatial Access to Healthcare Services in Nairobi: an ecological study
Authors: Nyamai Mutono , Wright Jim A. , Mutunga Mumbua , Mutembei Henry , Thumbi SM
Published: October 2021

Background

Geographic accessibility is an important determinant of healthcare utilisation and is critical for achievement of universal health coverage. Despite the high disease burden and severe traffic congestion in many African cities, few studies have assessed how traffic congestion impacts geographical access to healthcare facilities and to health professionals in these settings.
Methods

Using data on health facilities obtained from the Ministry of Health in Kenya, we mapped 944 primary, 94 secondary and four tertiary healthcare facilities in Nairobi County. We then used traffic probe data to identify areas within a 15-, 30- and 45-minute drive from each health facility during peak and off-peak hours and calculated the proportion of the population with access to healthcare in the County. We employed a 2-step floating catchment area model to calculate the ratio of healthcare and healthcare professionals to population during these times.
Results

During peak hours, <70% of Nairobi’s 4.1 million population was within a 30-minute drive from a health facility. This increased to >75% during off-peak hours. In 45 minutes, the majority of the population had an accessibility index of one health facility accessible to more than 100 people (<0.01) for primary health care facilities while secondary and tertiary health facilities had a ratio of one health facility for more than 10,000 people (<0.0001) and at least two health facilities per 100,000 people (>0.00002) respectively. Of people with access to health facilities, a sub-optimal ratio of <2.3 healthcare professionals per 1000 people was observed in facilities offering primary and secondary healthcare during peak and off-peak hours.
Conclusion

These findings can guide urban planners and policymakers in improving access to healthcare facilities to optimise coverage during peak and off-peak traffic times. Similarly, growing availability of traffic probe data in African cities should enable similar analysis in other countries.
Detection of Clinically Relevant Copy Number Variations and Genes in a Bangladeshi Cohort of Neurodevelopmental Disorders
Authors: Akter Hosneara , Rahman Muhammad Mizanur , Sarker Shaoli , Basiruzzaman Mohammed , Islam Mazharul , Rahaman Md. Atikur , Rahaman Md. Ashiquir , Eshaque Tamannyat Binte , Dity Nushrat Jahan , Sarker Shouvik , Amin Md. Robed , Hossain Md Monir , Lopa Maksuda , Jahan Nargis , Hossain Shafaat , Islam Amirul , Mondol Ashaduzzaman , Faruk Md Omar , Saha Narayan , Kundu Gopenkumar , Kanta Shayla Imam , Kazal Rezaul Karim , Fatema Kanij , Rahman Md. Ashrafur , Hasan Maruf , Mollah Md. Abid Hossain , Hosen Md. Ismail , Karuvantevida Noushad , Begum Ghausia , Ashraf Zehra Binte , Nassir Nasna , Nabi A.H.M. Nurun , Uddin KM Furkan , Uddin Mohammed
Published: October 2021

Background: Copy number variations (CNVs) play a critical role into the pathogenesis of neurodevelopmental disorders (NDD) among children. In this study, we aim to identify clinically relevant CNVs, genes and their phenotypic characteristics in an ethnically underrepresented homogenous population of Bangladesh. Methods: We have conducted genome-wide chromosomal microarray analysis (CMA) for 212 NDD patients with male to female ratio of 2.2:1.0 to identify rare chromosomal abnormalities (deletion /duplication/ rearrangements). To identify candidate genes within the rare CNVs, multiple gene constraint metrics (i.e. “Critical-Exon Genes (CEGs)”) were applied to the population data. Autism Diagnostic Observation Schedule-Second Edition (ADOS-2) was followed in a subset of 95 NDD patients to assess the severity of autism and all statistical tests were performed using R package. Results: In our cohort, the head circumference of males are significantly greater than females (p=0.0002). Of all samples assayed, 12.26% (26/212) and 47.17% (100/212) patients carried pathogenic and variant of uncertain significance (VOUS) CNVs, respectively. 2.83% (6/212) pathogenic CNVs are located at the subtelomeric regions. Further burden test identified females are significant carriers of pathogenic CNVs in comparison to males (OR=4.2; p=0.0007). ADOS-2 subset show severe social communication deficit (p=0.014) and overall ASD symptoms severity (p=0.026) among the patients carrying duplication CNV compared to the CNV negative group. Candidate gene analysis identified 153 unique CEGs in pathogenic CNVs and 31 in VOUS. Of the unique genes, 18 genes were found to be in smaller (<1 MB) focal CNVs and identified PSMC3 gene as a potential candidate gene for Autism Spectrum Disorder (ASD). Moreover, we hypothesized that KMT2B gene duplication might be associated with intellectual disability. Conclusion: Our results show the utility of CMA for precise genetic diagnosis and its integration into the diagnosis therapeutics and management of NDD patients.
Redescription and phylogenetic analysis of the type species of the genus Panagrellus Thorne, 1938 (Rhabditida, Panagrolaimidae), P. pycnus Thorne, 1938, including the first SEM study
Authors: Abolafia Joaquín , Vecchi Matteo
Published: October 2021

The identity of Panagrellus pycnus, the type species of the genus Panagrellus, is discussed after studying specimens from a cultured population collected in Italy that fits the original material of the species. A new characterization is consequently provided as follows: body 0.93–1.32 mm long, lip region continuous with the adjoining body, stoma with gymnostom very reduced, pharynx with not swollen metacorpus, neck 161–203 µm long, excretory pore at level of the metacorpus, post-vulval uterine sac 99–162 µm long or 2.6–3.8 times as long as the body diameter divided in a short tubular proximal part and a long swollen distal part, vulva post-equatorial (V = 63–69), female tail conical elongate with acute terminus (133–170 µm, c = 6.8–8.1, c’ = 4.9–7.0), male tail conical elongate with acute terminus (104–137 µm, c = 7.8–10.9, c’ = 3.6–5.1), and spicules 70–81 µm long having angular hook-like and very curved ventrad lamina ending in a spatulate tip with a refringent forked axis. The evolutionary relationships of this species and the genus Panagrellus, as derived from the analyses of 18S and 28S rDNA fragments, are discussed. Additionally, the phylogenetic relationships among the members of the infraorder Panagrolaimomorpha is studied, being the genus Tarantobelus transferred to the family Panagrolaimidae and the new subfamily Tarantobelinae n. subfam. is proposed to accommodate it.
'Build Back Better' or 'Business as Usual'? Notes on a Post-Covid Urbanization Paradigm in the Arab World and Beyond
Authors: Elsheshtawy Yasser
Published: October 2021

As the world's metropolitan centres are slowly entering into what has been described as a post-Covid urbanization paradigm, a number of international organizations, consultancies and think tanks have been vocal in suggesting that we have an opportunity to 'build back Better'. Yet many
critics have pointed out that such approaches are in fact nothing but a reconstitution of pre-pandemic agendas that ultimately will result in exclusionary measures by catering for a select few at the expense of the many. This essay reflects on these matters by providing a brief overview of
changes that have taken place worldwide, and exploring the extent to which the pandemic has impacted urban research. The discussion then turns to the Arab world. To that end some of the ongoing projects in two major cities in the region – Cairo and Riyadh – are examined in detail
to understand how they constitute a continuation of conventional practices and how they may result in gentrification. Ultimately the aim is to highlight that we are faced with a truly unique opportunity to re-configure our cities to be more humane and responsive to people's needs and that
we should not succumb to the allure of financial profit by reconstituting and revamping old agendas.
Creativity, the City, and the Future
Authors: Wray Ian
Published: October 2021

Could the marriage of online meetings, emails, social media, worldwide pandemic, 'working from home', and home deliveries really signal the end of cities? If the story of cities has not come to an end, how might they evolve in response to these new impulses, particularly in the UK?
This paper begins to provide some answers to these pressing questions. It does so by turning to London's urban history, to the 1960s and 1970s anti-urban ethos, to the fall and rise of London and New York in the 1970s and 1980s, and especially by applying to cities theories of innovation that
have been developed in the context of managing business and explaining the creative process. The discussion casts doubt on the city pessimists and suggests that although cities may be restructured to combat the impacts of Covid-19, they certainly won't be abandoned.
Risk and Supply Chain Mitigation Analysis Using House of Risk Method and Analytical Network Process (A Case Study on Palm Oil Company)
Authors: Kurniawan Shelvy , Marzuky Denny , Ryanto Rio , Agustine Vanny
Published: October 2021

This research studied PT XYZ, a company engaged in the palm oil industry which has eleven subsidiaries spread across five provinces in Indonesia, namely North Kalimantan, West Kalimantan, East Kalimantan, Central Kalimantan, and South Sumatra. The research focused on analyzing supply chain risks in PT A, a subsidiary of PT XYZ.. The objective was to find out and reduce unexpected costs that the company may experience caused by the risks in supply chain. Furthermore, the aim was to determine priority of risk agents and risk mitigation actions. The research method was a mixed methods, which combined both qualitative and quantitative analysis to answer the research questions. Data analysis procedure involved Supply Chain Operations Reference (SCOR), House of Risk (HOR) 1 and Analytic Network Process (ANP). The SCOR method was used for mapping supply chain activities, the HOR 1 was to determine the priority of the risk agent, and the ANP was to determine the priority of mitigation actions. The results show that there are 36 risk events and 35 risk agents. 19 risk agents are categorized as priority risks and 11 preventive actions are proposed to be implemented by PT XYZ. The research suggests that the company implement mitigation actions according to priority in accordance with the research results, for example, by improving the condition of the main garden road.
THE EFFICIENCY OF ONLINE LEARNING DURING THE COVID-19 PANDEMIC: COMPARATIVE ANALYSIS OF SOUTHEAST EUROPEAN COUNTRIES AS PARTICIPANTS IN THE NEW PATH OF EDUCATION
Authors:   University “Haxhi Zeka’’, Peć/Pejë, Republic of Kosovo, Miftari Vehbi , A. Dzogovic Suada ,   University “Haxhi Zeka’’, Peć/Pejë, Republic of Kosovo, Dzogovic Anela ,   University “Haxhi Zeka’’, Peć/Pejë, Republic of Kosovo, Zdravkovska-Adamova Blagojka ,   South East European University, Tetovo, Republic of North Macedonia
Published: October 2021

The focus of this research is education during the coronavirus pandemic in Southeastern European countries (Kosovo, Bosnia and Herzegovina and North Macedonia). It encompasses elementary education, high schools and higher education. The aim of the research is multiple. With it, we want to present methods of distance learning during the pandemics in the above mentioned countries, challenges and advantages that have emerged, as well as potential solutions for removing faults. This is primarily qualitative research relying on several methods. We conducted interviews to understand the experiences of different stakeholders participating in the education process. This research also relies on quantitative data, i.e. researches doing by The University of Prishtina, Pedagogical Institute of Kosovo, as well as results of opinion polls and research conducted by Student Parliament and Senate of the University of Sarajevo. Their research was conducted throughout the academic year 2020/2021. Also, we compiled different texts from media, as well as statements from different stakeholders. Our method is primarily inductive – because in some cases general ideas and conclusions about distance learning in Kosovo and Bosnia and Herzegovina are based on different individual examples. Information in this research in relation to the section on North Macedonia is mainly based on three sources: Data from the website of Ministry for Education and Science of the Republic of North Macedonia; Morphosis Foundation Survey from September 2020 entitled Status and Challenges for Managing Online Teaching in Primary School; and Findings from the research with directors, teachers, and parents: Experience and Attitudes about Distance Learning, a document prepared by Reactor. Our key conclusion is that Kosovo, Bosnia and Herzegovina and North Macedonia were not an exception regarding to the problems that arose during the pandemic in terms of education, such as online teaching, adapting students to new learning conditions, training of teachers for teaching in extraordinary and new circumstances, assessment criteria, etc. However, the situation has also brought opportunities to re-think existing education models and to find new solutions at schools and universities.
THE BASIC PRINCIPLES OF ADEQUATE ANTHROPOLOGY BY KAROL WOJTYLA
Authors: Dovhan Mariia Hryhorivna
Published: October 2021

Problem setting. Anthropological issues are one of the key areas of research in both the humanities and natural sciences. Karol Wojtyla’s philosophical and theological heritage is a valuable object of study in view of the thinker’s study of human problems in various philosophical fields, analysis of the results of scientific achievements and the distinctive features of methodology. The importance of Karol Wojtyla’s anthropological teaching is determined by its practical nature.

Recent research and publications analysis. Of particular interest are the works of the following researchers: Gh. Pilusj, J. Kupnyj, I. Galjarovich, P. Bortkevych, F. Ghrenjuk, Ch. S. Bartnik, S. Kovaljchyk, M. Ghrabovsjkyj, P. Jarocjkyj, O. Kyrylova, I. Savynsjka, O. Bondar. The variety of theories and often the fragmentary nature of research reveals the need for their systematization and rethinking the anthropological teachings of Wojtyla.

Paper objective. The goal of the paper is to study the peculiarities of Karol Wojtyla’s adequate anthropology.

Paper main body. The paper reveals the basis of the philosophical and anthropological doctrine of the thinker, which is represented in the unity of spiritual, religious, and moral manifestations of human transcendence. It analyzes the connection of Wojtyla’s anthropological heritage with personalism, phenomenology, and Thomism. It is established that the creative heritage of Karol Wojtyla is characterized by a kind of conceptual and categorical apparatus that combines philosophical and theological concepts based on ethical terms.

Conclusions of the research. It is established that, in contrast to the Aristotelian-Thomistic interpretation, Wojtyla considered freedom to be the basis of all human qualities. It is investigated that the basic concepts of adequate anthropology of Wojtyla include: person, work, freedom, experience, love, law, beauty, truth, goodness, duty, and responsibility. Based on the research, I concluded that Karol Wojtyla is a representative of ethical personalism.
TAXONOMY OF PARTS AND ITS LOGICAL PRINCIPLES IN MEREOLOGY
Authors: Yurkevych Olena
Published: October 2021

Problem setting. One of the complex and controversial theoretical issues is the meteorological division and construction of the taxonomy of parts. After all, humanitarian and social subjects, due to their own specifics related to their existence, need other grounds for distribution. Thus, the study of the taxonomy of parts and its logical principles in meteorology will help to deepen the understanding of the specifics of the humanities and social sciences and the development of the logical basis of the methodology of the humanities. Recent research and publications analysis. Analysis of sources of origin, modern theoretical works on meteorology indicate unresolved issues regarding the taxonomy of parts, the possibility of involving mathematical set theory, doubts about the stability of the principles of part ratio, the problem of identity and more. Paper objective. The purpose of the study is to consider the problem of division of the whole into parts and the principles of construction of the taxonomy of parts, the reasons for their stability or doubt in meteorology. Paper main body. Mereological structure consists of a whole and parts. Parts can be constituent elements, components, ingredients, portions, aspects, parties, members, etc. Parts can be considered in the abstract (as a part in relation to any whole) or in relation (taking into account the function, ie as a component of the whole). Parts can be concrete or abstract. When analyzing the types of parts, there may be a problem of identity. The order of the parts, their distribution and relationship are determined by reflexivity, transitivity and antisymmetry. All three principles - reflexivity, transitivity and antisymmetry, together with taxonomy appear as the theoretical basis of classical meteorology. Conversely, in non-classical meteorology, arguments are developed regarding doubts about the stability of these principles. Additional principles are the principles of composition and decomposition. Extensional mereology demonstrates its limitations in relation to living objects. Conclusions of the research. The article analyzes the types of parts, the principles of their relationship, doubts about the stability of these principles and their assessment of the identity of parts and the whole. In our opinion, this opens the possibility of further distinguishing between extensional mereology and meteorological approach in hermeneutic logic, which determines the further success of building an authentic logic of humanitarian and social cognition.
YOUTH PARTIES IN EU COUNTRIES
Authors: Huk Luidmyla Ivanivna , Grabchak Marta Oleksandrivna
Published: October 2021

The article attempts to conduct a comparative analysis of youth parties in the EU. Investigate theoretical approaches to understanding the concept of "political party" - as well as to highlight the main features and characteristics of youth parties.
UKRAINIAN CATHOLIC RELIGIOUS ORGANIZATIONS UNDER CONDITION OF THE RUSSIAN MILITARY AGGRESSION
Authors: Vasilieva Olha Vasylivna
Published: October 2021

The organizational structure of the religious organizations of the Ukrainian Greek Catholic Church and the Roman Catholic Church in Ukraine is investigated in the article. The essence, directions, forms of activity of Catholic religious organizations in modern conditions of the Russian military aggression against Ukraine are analyzed. The peculiarities of the functioning of Ukrainian Catholic religious organizations on the occupied part of Donbas are characterized. The role of religious organizations of the Catholic faith in carrying out socially useful activities in Ukraine in the context of national security is highlighted.
POSTPANOPTICUM: METAMORPHOSES OF CULTURE CONTROL IN A DIGITAL SOCIETY
Authors: Kovalenko Inna , Meliakova Yuliia , Kalnytskyi Eduard
Published: October 2021

The article is devoted to the analysis of the peculiarities of control practices in the situation of «liquid modernity».  The metaphor of the panopticon proposed by M. Foucault is taken as a starting point. The characteristic features of the digital infrastructure of social control are considered. Features of banoptic and synoptic logic of tracking as post-panoptic forms of social control are shown. The flexibility and variability of control made possible by the latest digital technologies testify to a specifically new mode of power to human relations.
SOCIAL NETWORKS INFLUENCE ON THE AXIOGENESIS OF PERSONALITY
Authors: Manuylov Evgen Mykolayovych , Kalinovsky Yuriy Yuriyovych
Published: October 2021

The essential characteristics of the "personality axiogenesis" concept are analyzed. The peculiarities of values understanding in the context of postmodern culture, development of the information society, spread of virtual communities is determined. Social networks ambivalent influence on the formation of the individual value world is revealed. It is substantiated that social networks hold the transformation of traditional values, the formation of specific axiologems of being.
THE CONCEPT OF THE ELECTRONIC PERSON IN DIGITAL REALITY
Authors: Pavlenko Zhanna , Vodorezova Susanna
Published: October 2021

The comprehension of the content and volume of the concept of the electronic person in the conditions of digital reality is carried out. It is justified that the use of artificial autonomous agents, along with the benefits, is accompanied by a set of risks and should be seriously evaluated in terms of freedom, dignity, privacy, security, health, self-determination and non-discrimination, personal data protection, etc.
Review on engine vibration fault analysis based on data mining
Authors: Jia Zhu , Sharma Ashutosh
Published: October 2021

Through equipment monitoring, the uptimes of machines are enhanced in the industrial applications. The unpredicted failures risks are minimized by the proper equipment monitoring. The machine vibrations are increased caused by the failure modes. The vibration data requires effective analysis by the accurate assessment of the machine equipment. For fault feature selection and detection of faults in rotating equipment, the empirical knowledge is required. Low efficiency of the methods and motor speed control are the main drawbacks of the existing techniques. So the basic aim of this paper is the detection of rotating equipment faults by utilizing the vibration analysis. The motor vibration is analyzed and monitored using spectrum analysis. The spectral content are extracted and fed into the classifier like k-Nearest neighbors (KNN), back-propagation neural network BPNN, Sparse Representation Classifier (SRC), Support vector machine (SVM) and Random Forest (RF) for the type of failure prediction and analyze the unbalance condition (UNB), bearing faults (BDF), and broken rotor bars (BRB) faults. The RF classifier is better as compared to other classifiers in terms of accuracy, precision and recalls values by approximately 10.92 %, 11.03 % and 20.13 % respectively.
Mathematical simulation of adaptive vector finite element method for the analysis of electromagnetic vibration spectrum field response
Authors: Cheng Yiyuan , Su Mingyang , Hui Ming , Liu Wei , Zheng Yangbing
Published: October 2021

Mathematical simulation plays a vital role in the analysis of electromagnetic vibration spectrum field response. This article realizes a three-dimensional adaptive vector finite meta-acting algorithm of controlled source electromagnetic vibration spectrum (CSEM) field to address 3D meshing for the simulation of terrain fluctuations and complex electrical anomalies. The adaptive methods utilized in this article is employed for one-time field and secondary field separation in order to calculate electromagnetic vibration spectrum field response. This response can effectively solve the source singularity in finite meta-simulation and improves the numerical accuracy of electromagnetic vibration spectrum field near the field source. The two approaches analysed in this article are CSEM one-dimensional positive algorithm and finite meta-method. The adaptive mesh refinement algorithm based on post-test error estimation is used in this paper to guide the mesh refinement to reduce man-made errors caused by designing a grid. The validity of the proposed algorithm is verified through numerical simulation of one-dimensional and three-dimensional models. The outcomes obtained reveals that the finite solution of one-dimensional model coincides well with the analytical solution. The relative error of electromagnetic vibration spectrum field amplitude is about 1 %, and the overall phase difference of less than 1 degree is observed. It is analysed that the three-dimensional model finite solution also fits well with the finite volume solution and the controlled source electromagnetic vibration spectrum response with three-dimensional tilt plate abnormality is simulated. This experimental analysis shows the ability and effectiveness of the algorithm to simulate the electromagnetic vibration spectrum field of complex geoelectrical structure.
Introduction to the Special Issue: Futuristic trends and emergence of technology in biomedical, nonlinear dynamics and control engineering
Authors: Veselov Gennady , Tselykh Alexey , Sharma Ashutosh
Published: October 2021

In the current era of emerging technologies such as deep learning, artificial intelligence, multimedia data analysis, Internet of Things (IoT), the significant role of vibration analysis can be seen in biomedical, nonlinear dynamics, and control engineering. Despite the numerous applications, lots of challenges and issues are still needed to address like nonlinearity, fault diagnosis, vibration spectrum analysis, and biomedical data monitoring and processing. The aim of this Special Issue is to cover and address all the aforesaid challenges and issues and practical solutions for such emerging technologies. We have received 21 manuscripts in total for this Special Issue across the globe and after the rigorous review process, only 10 manuscripts have been accepted for publication. A brief overview of contributions to this Special Issue is as underneath.
Development of regional market of corporate voluntary health insurance: The case of St. Petersburg
Authors:   St. Petersburg State University, Drozdova Natalia P. , Marycheva Oksana A. ,   LTD “bioMerieux RUS”, Sklyar Tatiana M. ,   St. Petersburg State University
Published: October 2021

The paper discusses a pilot study aimed to identify the factors of development of the regional market for corporate voluntary health insurance in St. Petersburg during the period from 2015 to 2018. Based on the review of scientific works of Russian and foreign authors as well as the analysis of international experience, the key factors influencing the functioning of the corporate voluntary health insurance market are identified including the economic development of the region, demographic situation, changes in the labor market, accessibility of medical care, and personal characteristics of the insured. The results of quantitative modeling showed that the development of the corporate voluntary health insurance market in St. Petersburg is influenced by the factors related to the economic well-being of the region and the state of labor market. Such factors as the average per capita income of the population, the unemployment rate as well as the index of prices and tariffs for paid medical services turned out to be significant. In addition, a qualitative analysis of the demand for corporate voluntary health insurance was carried out. The analysis of a structured survey Russian and international companies managers proved the following assumptions: voluntary health insurance policies are more often offered to employees of large and medium-sized organizations operating mainly in Moscow and the Moscow region compared to companies whose main number of employees work in St. Petersburg and the Leningrad Region; international companies are more likely to provide voluntary health insurance policies to their employees than Russian ones. The study offers practical recommendations to stakeholders — the authorities, insurers and employers.
Socio-technological system of sharing economy
Authors:   St. Petersburg State University, Singh Amarjeet
Published: October 2021

Sharing economy is a system which functions successfully provided that technological and social subsystems complement each other forming an indivisibly combined cohesive structure. The premise of balancing social and technological aspects is proposed in the socio-technological theory. Social issues call for social innovation to fulfil the needs and requirements of the society as well as individual citizens. The goal of this paper is to fill the gap in the extant literature by proposing a comprehensive framework of sharing economy based on the socio-technological theory. This study carried out a systematic literature review of works on sharing economy and socio-technological theory in order to develop a conceptual framework. There were identified different social motives associated with each of the subsystems; interplay between them was established. This study contributes to the increasing research by presenting a holistic view of sharing economy through the theoretical lens of socio-technology keeping society as well as consumer needs and requirements at its focal point.
Perfil neuromuscular del tren inferior en cadetes que realizan curso paracaidismo militar
Authors: Barreto Triana Jorge Eduardo , Cruz Rivas Jana Isabel , Hernández Ríos Yeferson Andrés , Cubides Amézquita Jenner Rodrigo
Published: October 2021

Algunos estudios han mostrado una tasa de lesión en miembros inferiores de 2 por cada 1000 saltos realizados en el paracaidismo militar. Por tal razón, se requiere una buena estabilidad de rodilla y tobillo, con una adecuada distribución de las cargas y energía cinética en el momento del contacto con el suelo. El objetivo del presente artículo es identificar los efectos del curso de paracaidismo militar en el acondicionamiento neuromuscular del tren inferior. La metodología utilizada en el estudio es observacional-descriptiva, e incluye la evaluación de 40 cadetes de género masculino mediante test de salto contramovimiento (CMJ). Los resultados revelan cambios en el acondicionamiento neuromuscular que se podrían deber a fatiga muscular o modificación propios del entrenamiento recibidos en el curso.
Избирательная сольватация красителя 4-DASPI в бинарном растворителе вода-этиленгликоль
Authors: Степко А.С. , Медведева А.А. , -=SUP=-1-=/SUP=- А.В. Кошкин , Лебедев-Степанов П.В.
Published: October 2021

Solvatochromic shifts of the absorption spectra maxima of the dye 4-DASPI (4- [4- (dimethylamino) styryl] -1-methylpyridinium iodide) in a binary solvent water-ethyleneglycol in the concentration range 0-100% were experimentally investigated. The dependence of the solvatochromic shift on the macroscopic dielectric constant of the solution and the concentration of ethyleneglycol was determined. The Onsager-Liptay model was used for the theoretical interpretation of the experimental data. It made it possible to estimate the effective dielectric constant in the microscopic area that contacts with dye chromophore taking into account the measured solvatochromic shifts. It was found that the value of the dielectric constant in the solvation shell of this dye differs significantly from the macroscopic value. The solvation shell is significantly enriched by ethyleneglycol (preferential solvation) over the components’ concentration range. The enrichment reaches its maximum approximately in the middle of this range. The composition of the dye solvation shell at different concentration is discussed.
Свободное вращение простых молекул и характеристические температуры в стеклообразных полимерах
Authors: Рыжов В.А.
Published: October 2021

Purely rotational spectra of CO and HCl molecules added as a probe to polypropylene (PP) and polyvinyl chloride (PVC) were obtained and analyzed. It is shown that the shape of the bands of these spectra, which reflects the degree of disturbance of the rotational motion, is strongly influenced by the local dynamics of the polymer matrix. From the change in the integrated intensity of absorption with the temperature were found temperatures of the transition from free rotation of CO and HCl molecules to their libration, as well as the temperatures of the onset of defrosting of the conformational mobility of the chains of PP and PVC macromolecules.
Фотолюминесценция политетрафторэтилена в ближней инфракрасной области спектра
Authors: Киселев В.М. , Багров И.В. , Стародубцев А.М. , Гоголева Н.Г.
Published: October 2021

In this work, a study of the photoluminescence of polytetrafluoroethylene (fluoroplast-4, also known under the trade mark as Teflon) in the near infrared region of the spectrum under its excitation by ultraviolet and visible radiation was carried out. It is shown that the photoluminescence spectrum observed from the surface of the fluoroplastic upon its excitation has a distinct characteristic luminescence profile, which coincides in its position with the phosphorescence spectrum of singlet oxygen.
Генерация второй гармоники-суммарной частоты в тонком сферическом слое. II. Анализ диаграмм направленности
Authors: Толкачёв А.И. , Капшай В.Н. , Шамына А.А.
Published: October 2021

The solution to the problem of second harmonic–sum frequency generation by two coherent plane electromagnetic waves with elliptical polarizations and equal frequencies in a thin spherical layer is analyzed graphically. Asymmetries are introduced that quantitatively describe the shape of three-dimensional directivity patterns (spatial distribution of the power density of second harmonic–sum frequency radiation). Three-dimensional directivity patterns and asymmetries are analyzed for various combinations of the parameters: ratio of the complex amplitudes of the incident waves, angle between the wave vectors of the incident waves (the opening angle), ellipticities, orientations of polarization ellipses, spherical particle size. It is found that, at small particle sizes, each anisotropy type corresponds to its own individual directivity pattern. It is revealed that, for one of the anisotropy types, the shape of the directivity pattern almost does not change for nearly all possible ranges of the above parameters.
Генерация второй гармоники-суммарной частоты в тонком сферическом слое: III. Свойства решения
Authors: Шамына А.А. , Капшай В.Н. , Толкачёв А.И.
Published: October 2021

Mathematical properties of functions characterizing symmetries of spatial distribution of second harmonic–sum frequency radiation are determined. The conditions at which there occurs no generation and the conditions at which the polarization of the generated radiation is linear are found. The revealed properties are systematized by their manifestations in the directivity patterns of the generated radiation. Methods based on these properties for determining the components of the nonlinear dielectric susceptibility tensor are proposed. The relationship is described between the revealed properties as well as conditions and previously found similar properties and conditions for the phenomena of second–harmonic generation and sum–frequency generation.
MINI-REVIEW OF PHYTOCHEMICALS OF TEN FICUS SPECIES
Authors: MUDHAFAR MUSTAFA , ALSAILAWI HA , ABDULRASOOL M. M. , JAWAD RUAA K. MOHAMMED , A. D. MAYS
Published: October 2021

The present work aimed to review ten species of Ficus which is belong to the Moraceae family. 
In total, 36 articles were reviewed by using the online search engine PubMed, Scopus, Google Scholar, and Web of Science. 
Ten species of Ficus were searched for phytochemicals documentation, which resulted in 250 secondary metabolites and 400 different compounds. Alkaloids compounds such as liriodenine and lysicamine, terpenes, steroids, and flavonoids were found to have anticancer, antibacterial, antifungal, and other biological activities. 
Most Ficus species contain secondary metabolites compounds with different types of application. This mini-review provides insights on Ficus’s phytochemical compounds and their importance as medicinal properties.