bluuebunny/crossref_metadata_2025 huggingface dataset:
Essential Oils of the Leaves of Epaltes australis Less. and Lindera myrrha (Lour.) Merr.: Chemical Composition, Antimicrobial, Anti‐inflammatory, Tyrosinase Inhibitory, and Molecular Docking Studies
Authors: Pham Ty Viet , Huu Cuong Le , Hong Ha Tran Thi , Dinh Luyen Nguyen , Xuan Ha Nguyen , Hoang Thao Xuan , Thanh Hao Nguyen , Huy Gioi Dong , Thu Thuy Ta Thi , The Son Ninh
Published: October 2023

Epaltes australis Less. has been traditionally used to treat fever and snake bites, whereas Lindera myrrha (Lour.) Merr. is well‐known for addressing colds, chest pain, indigestion, and worm infestations. This study marks the first report on the chemical compositions and biological potentials of essential oils extracted from the leaves of Epaltes australis and Lindera myrrha. Essential oils obtained by hydro‐distillation were analysed using the GC/MS (gas chromatography‐mass spectrometry). E. australis exhibited a predominant presence of non‐terpenic compounds (46.3 %), with thymohydroquinone dimethyl ether as the major compound, constituting 44.2 % of the oil. L. myrrha leaf oil contained a good proportion of sesquiterpene hydrocarbons (56.8 %), with principal compounds including (E)‐caryophyllene (22.2 %), ledene (9.7 %), selina‐1,3,7(11)‐trien‐8‐one (9.6 %), and α‐pinene (7.0 %). Both essential oils exhibited antimicrobial activity against the bacteria Bacillus subtilis and Clostridium sporogenes, and Escherichia coli, and the fungus Aspergillus brasiliensis. L. myrrha leaf essential oil exhibited potent control over the yeast Saccharomyces cerevisiae with a MIC of 32 μg/mL. Additionally, L. myrrha leaf oil showed strong anti‐inflammatory activity with an IC50 value of 15.20 μg/mL by inhibiting NO (nitric oxide) production in LPS (lipopolysaccharide)‐stimulated RAW2647 murine macrophage cells. Regarding anti‐tyrosinase activity, E. australis leaf oil showed the best monophenolase inhibition with the IC50 of 245.59 μg/mL, while L. myrrha leaf oil successfully inhibited diphenolase with the IC50 of 152.88 μg/mL. From molecular docking study, selina‐1,3,7(11)‐trien‐8‐one showed the highest affinity for both COX‐2 (cyclooxygenase‐2) and TNF‐α (tumor necrosis factor‐α) receptors. Hydrophobic interactions play a great role in the bindings of ligand‐receptor complexes.
Inguinal hernia repair in an elderly patient with moderate aortic stenosis under sole epidural anesthesia: A case report
Authors: Devkota Sagar , Thapa Yubaraj
Published: October 2023

Key Clinical Message

In resource limited settings, epidural anesthesia can be a safe option for elderly patients with aortic stenosis for lower abdominal surgeries as the hemodynamic changes are known to be less as compared to spinal or general anesthesia.

Spinal or general anesthesia in an elderly patient with aortic stenosis is always a challenge for anesthesiologists. It is even more challenging in a resource limited setting. The marked hemodynamic changes associated with either spinal or general anesthesia increase the morbidity and mortality. We present a case of right inguinal hernia in a 71‐year‐old patient with hypertension, bradycardia, and moderate aortic stenosis planned for open mesh repair under sole epidural anesthesia.
Bochdalek hernia presenting as recurrent fever and bicytopenia in a pediatric patient: A rare case report
Authors: Salajegheh Pouria , Gilani Abolfazl , Yazdi Farzaneh , Sarmadian Roham , Habibzadeh Adrina
Published: October 2023

Key Clinical Message

Bochdalek hernia is a rare condition characterized by the displacement of abdominal contents into the thoracic cavity. Due to the nonspecific nature of symptoms, prompt diagnosis, and management by emergency care providers can be challenging. Treatment of a Bochdalek hernia typically involves the reduction in the herniated contents back into the abdominal cavity. In this case report, we present the case of a 1‐year‐old girl who presented to the emergency department with a fever and bicytopenia. Further evaluation revealed a Bochdalek hernia, which was successfully managed with surgical intervention. This case highlights the importance of considering a Bochdalek hernia in the differential diagnosis of patients presenting with recurrent nonspecific symptoms (fever and bicytopenia).
Cystic bronchiectasis in sarcoidosis
Authors: Jadav Raja Shekar , Dadana Sriharsha , Avula Akshay
Published: October 2023

Key Clinical Message

Pulmonary sarcoidosis can manifest in different radiologic patterns. Typical manifestations in high‐resolution computed tomography are bilateral perihilar lymphadenopathy, micronodules, and fibrotic changes. Atypical manifestations are mass‐like or alveolar opacities, honeycomb‐like cysts, miliary opacities, tracheobronchial involvement, and pleural disease. Cystic bronchiectasis in pulmonary sarcoidosis is rare, with only a few reported cases in the literature. We present another case of cystic bronchiectasis with a honeycomb‐like pattern in pulmonary sarcoidosis and with cardiac involvement. This case was presented as an abstract poster at the American Thoracic Society conference in 2022.
Sheathless CESI–MS versus LC–MS: Results of qualitative and quantitative analyses of the primary and secondary metabolites of Pleioblastus amarus bamboo shoots
Authors: Ren Yan , Liu Ying , Zhang Wenming , Ran Junfeng , Li Li , Zhang Zhidan
Published: October 2023

The bamboo shoot of Pleioblastus amarus (Keng) Keng f. is a medicinal and edible resource in China. In this study, three separation techniques were applied to identify the primary and secondary metabolites component of P. amarus bamboo shoots, including sheathless capillary electrophoresis electrospray ionization–mass spectrometry (CESI–MS), reverse‐phase liquid chromatography–MS (RPLC–MS), and hydrophilic interaction liquid chromatography–MS (HILIC–MS). A total of 201 metabolites were identified by the three methods. Among those metabolites, 146 were identified by RPLC–MS, 85 were identified by HILIC–MS, and 46 were identified by sheathless CESI–MS. These methods were complementary and had a linear coefficient. CESI–MS presented advantages in the identification of isomers, high sensitivity, very low sample usage, and good detection of polar and nonpolar metabolites, showing its unique applications in food analysis and prospects in metabolic research.
Marchiafava–Bignami disease after the white matter lesions: A case report
Authors: Zhou Zhiwei , Chu Qiongxian , Du Xingyu , Pan Chunhua , Zhou Hongyan , Xu Zhongxiang , Xu Zucai , Xu Ping
Published: October 2023

Marchiafava–Bignami disease (MBD) is an uncommon alcoholism‐related neuropsychiatric disorder, featured with symmetrical demyelination of part or whole corpus callosum (CC). Previous studies reported follow‐up neuroimaging changes with necrosis, cystic degeneration, and atrophy of the CC after the diagnosis of MBD, but it is unclear whether the white matter is damaged before MBD. We report a case of alcoholic MBD whose magnetic resonance imaging revealed structural lesions in the white matter before the typical demyelination of CC during MBD, which support the prior hypothesis that chronic hazardous drinking may initially lead to microstructure abnormalities of the white matter and CC through some possible mechanisms, then microstructure lesions in the CC, and white matter deterioration into extensive demyelination, that is MBD. In future clinical practice, when patients with chronic alcoholism seek treatment for neuropsychiatric disorders, they may need to undergo repeated MRI scans to reveal progressive neuroimaging features before and after MBD.
Epidemiologic, clinical and therapeutic features of primary cutaneous lymphomas in Morocco
Authors: Hali Fouzia , Zakaryaa Salma , Senouci Karima , Zeggwagh Zineb , Mernissi Fatima Zahra , Elloudi Sara , Hashas Fatima Zahra , Amal Said , Hocar Ouafa , Aboudourib Maryem , Kelati Awatef , Chikhaoui Inas , Quessar Asmaa , Chiheb Soumiya
Published: October 2023

Background

Few epidemiological studies on primary cutaneous lymphomas are available and related to limited populations.

Objectives

To characterize the epidemiologic, clinical and therapeutic features of primary cutaneous lymphomas from a global perspective at the national level.

Methods

A cross‐sectional descriptive multicenter study including patients treated for cutaneous lymphomas at dermatology and venereology departments of different university hospitals in the kingdom of Morocco from January 2012 to December 2021.

Results

Our multicenter cohort consisted of 402 patients. The median age was 56 years (15–114) with a male predominance (61%, 245 cases). Based on the WHO‐EORTC classification, the most frequent histological type was cutaneous T‐cell lymphoma (CTCL) (88% of cases). Of these, mycosis fungoides (MF) was the most common (78%). B‐cell lymphomas represented 12% of cases, mainly centro‐follicular B‐cell lymphoma (40%). The clinical presentation was most frequently erythematous and scaly infiltrated lesions in 187 CTCL patients (52.6%), and nodular lesions in 37 patients (78%) with B‐cell lymphomas. Treatment modalities depended on the tumour's histological type and stage and included: topical corticosteroids and phototherapy in 52% of cases, monochemotherapy, radiotherapy, photopheresis and polychemotherapy. The evolution was marked by remission in 41% of patients, relapse in 17% and death in 12%.

Conclusions

Our national study provides data on primary cutaneous lymphomas in Morocco, never before mentioned in indexed literature. We identified 402 cases over a 10‐year period. A better knowledge of these entities is key to optimize diagnosis and therapy.
Enhanced Osteolysis Targeted Therapy through Fusion of Exosomes Derived from M2 Macrophages and Bone Marrow Mesenchymal Stem Cells: Modulating Macrophage Polarization
Authors: Ma Tianliang , Chen Sijie , Wang Jiahao , Liang Shuailong , Chen Mingyu , Liu Qimeng , Zhang Zheyu , Liu Guanzhi , Yang Yute , Hu Yihe , Xie Jie
Published: October 2023

Aseptic loosening of prostheses is a highly researched topic, and wear particle‐induced macrophage polarization is a significant cause of peri‐prosthetic osteolysis. Exosomes derived from bone marrow mesenchymal stem cells (BMSCs‐Exos) promote M2 polarization and inhibit M1 polarization of macrophages. However, clinical application problems such as easy clearance and lack of targeting exist. Exosomes derived from M2 macrophages (M2‐Exos) have good biocompatibility, immune escape ability, and natural inflammatory targeting ability. M2‐Exos and BMSCs‐Exos fused exosomes (M2‐BMSCs‐Exos) are constructed, which targeted the osteolysis site and exerted the therapeutic effect of both exosomes. M2‐BMSCs‐Exos achieved targeted osteolysis after intravenous administration inhibiting M1 polarization and promoting M2 polarization to a greater extent at the targeted site, ultimately playing a key role in the prevention and treatment of aseptic loosening of prostheses. In conclusion, M2‐BMSCs‐Exos can be used as a precise and reliable molecular drug for peri‐prosthetic osteolysis. Fused exosomes M2‐BMSCs‐Exos  were originally proposed and successfully prepared, and exosome fusion technology provides a new theoretical basis and solution for the clinical application of therapeutic exosomes.
Click Chemistry in Lithium‐Metal Batteries
Authors: Hu Ji , Wang Wanhui , Zhou Binghua , Sun Jianguo , Chin Wee Shong , Lu Li
Published: October 2023

Lithium‐metal batteries (LMBs) are considered the “holy grail” of the next‐generation energy storage systems, and solid‐state electrolytes (SSEs) are a kind of critical component assembled in LMBs. However, as one of the most important branches of SSEs, polymer‐based electrolytes (PEs) possess several native drawbacks including insufficient ionic conductivity and so on. Click chemistry is a simple, efficient, regioselective, and stereoselective synthesis method, which can be used not only for preparing PEs with outstanding physical and chemical performances, but also for optimizing the stability of solid electrolyte interphase (SEI) layer and elevate the cycling properties of LMBs effectively. Here it is primarily focused on evaluating the merits of click chemistry, summarizing its existing challenges and outlining its increasing role for the designing and fabrication of advanced PEs. The fundamental requirements for reconstructing artificial SEI layer through click chemistry are also summarized, with the aim to offer a thorough comprehension and provide a strategic guidance for exploring the potentials of click chemistry in the field of LMBs.
Organic Dye Molecule Intercalated Vanadium Oxygen Hydrate Enables High‐Performance Aqueous Zinc‐Ion Storage
Authors: Cui Rukun , Gu Jianmin , Wang Ning , Wang Yiran , Huang Xiaoyan , Zhang Senlin , Lu Li , Wang Desong
Published: October 2023

Although the layered vanadium oxide‐based materials have been considered to be one of the candidates for aqueous Zn‐ion batteries (AZIBs), it still faces inevitable challenges of unsatisfactory capacities and sluggish kinetics because of strong electrostatic interactions between Zn‐ions and structure lattice. This work addresses the strategy of pre‐inserting guest materials to vanadium oxide cathode using different intercalants. To achieve this goal, the small organic dye molecules, methyl orange (MO), and methylene blue (MB) are proposed as the intercalants for vanadium oxygen hydrate (VOH). It has been demonstrated that use of these intercalants can facilitate reaction kinetics between Zn2+ and VOH, leading to an improvement of specific capacity (293 mAh g−1 at 0.3 A g−1 for MO‐VOH and 311 mAh g−1 for MB‐VOH) compared to VOH, a large enhancement of excellent energy density (237.1 Wh kg−1 for MO‐VOH, 232.3 Wh kg−1 for MB‐VOH), and a prolong lifespan operation at 3 A g−1. The mechanism studies suggest that the weakened electrostatic interactions between the Zn–ions and V–O lattice after intercalating organic molecules contribute to boosting the electrochemical performance of AZIBs unveiled by charge density difference and binding energy.
Multiscale Imaging Techniques for Real‐Time, Noninvasive Diagnosis of Li‐Ion Battery Failures
Authors: Lee Mingyu , Lee Jiwon , Shin Yewon , Lee Hongkyung
Published: October 2023

With the increasing popularity of battery‐powered mobility, ensuring the safety and reliability of Li‐ion batteries (LIBs) has become critical for manufacturers. Despite advanced manufacturing processes for large‐scale Li‐ion cells, “latent defects” still unintentionally appear, due to imbalanced battery design, invisible faults, and extreme operating conditions. These defects cause performance degradation and can even lead to battery fires. Hence, early detection of latent defects, along with understanding the influence of cell parameters and operating conditions on battery failure scenarios, is crucial. For straightforward investigations and interpretations, noninvasive and in operando battery imaging techniques and methods have been proposed using X‐rays, neutrons, and ultrasound, as these can penetrate active and component materials and cell packaging. Moreover, magnetic‐field‐guided visualization of the current distribution pattern in cells under a current load has been proposed to identify invisible defects. This review thoroughly examines various imaging techniques for internal batteries, from the atomic and molecular levels in electrode materials and interfaces to macroscale battery systems. By assessing qualitative case studies and newly discovered phenomena, this review provides valuable insights into state‐of‐the‐art noninvasive battery imaging and its potential to improve the safety and reliability of LIB technology.
The dual impact of technological tools on health and technostress among older workers: an integrative literature review
Authors: Nedeljko Mihael , Gu Yang , Bostan Cristina Maria
Published: October 2023

The global population is ageing, life expectancy is gradually increasing, and employment is extended. We used an integrative literature review to study how using technological tools impacts the quality of working life among older workers.The integrative literature review method following PRISMA guidelines was used. The selection of articles in English was made according to the following inclusion criteria: scientific papers, content relevance, and topicality. The literature search covered the bibliographic-catalogue databases Web of Science, PubMed, and Scopus. After selection, a qualitative content analysis was applied to the data. From the initial twelve articles, we gained insight into how using technological tools impacts the quality of working life among older workers through a substantive analysis of the articles. Two content categories were identified: health of older workers and technostress. Regarding the impact on health, studies have focussed on various health outcomes like sleeping quality, mental health, workability arthritis as a chronic condition, physical and quality of life in older community-dwelling low-income, diet, physical activity, stress and tobacco use, stress, and job quality. Studies regarding technostress that we identified show mixed effects of significant and non-significant effects. Digital technologies can potentially improve the quality of working life among older workers but are currently under-researched. Further research is needed to develop effective interventions and evaluate their impact on the quality of life of older workers.
Three-dimensional echocardiography for the evaluation of hypertrophic cardiomyopathy patients: relation to symptoms and exercise capacity
Authors: Cardoso Isabel , Viegas José Miguel , Rosa Sílvia Aguiar , Brás Pedro Garcia , Grazina André , Cruz Inês , Branco Luísa Moura , Galrinho Ana , Fiarresga António , Lopes Luís R , Ferreira Rui Cruz
Published: October 2023

Patients with hypertrophic cardiomyopathy may exhibit impaired functional capacity, associated with increased morbidity and mortality. Systolic function is one of the determinants of functional capacity. Early identification of systolic disfunction may identify patients at risk for adverse outcomes. Myocardial deformation parameters, derived from three-dimensional (3D) speckle-tracking echocardiography (3DSTE) are useful tools to assess left ventricular systolic function, and are often abnormal before a decline in ejection fraction is seen. The aim of this study was to evaluate the correlation between myocardial deformation parameters obtained by 3DSTE and functional capacity in patients with hypertrophic cardiomyopathy. Seventy-four hypertrophic cardiomyopathy adult patients were prospectively evaluated. All patients underwent a dedicated 2D and 3D echocardiographic examination and cardiopulmonary exercise testing (CPET). Values of 3D global radial (GRS), longitudinal (3DGLS) and circumferential strain (GCS) were overall reduced in our population: 99% (n = 73) of the patients had reduced GLS, 82% (n = 61) had reduced GRS and all patients had reduced GCS obtain by 3DSTE. Average peak VO2 was 21.01 (6.08) ml/Kg/min; 58% (n = 39) of the patients showed reduced exercise tolerance (predicted peak VO2 < 80%). The average VE/VCO2 slope was 29.0 (5.3) and 16% (n = 11) of the patients had impaired ventilatory efficiency (VE/VCO2 > 34). In multivariable analysis, 3D GLS (β1 = 0.10, 95%CI: 0.03;0.23, p = 0.014), age (β1 = -0.15, 95%CI: -0.23; -0.05, p = 0.002) and female gender (β1 = -5.10, 95%CI: -7.7; -2.6, p < 0.01) were independently associated with peak VO2. No association was found between left ventricle ejection fraction obtain and peak VO2 (r = 0.161, p = 0.5). Impaired myocardial deformation parameters evaluated by 3DSTE were associated with worse functional capacity assessed by peak VO2.
Theorizing ‘The Gap’ Twenty Years Later: Global Development, Design, and Speculative Ethics in Edtech Research
Authors: Henry Jade Vu
Published: October 2023

Drawing from Feminist Science and Technology Studies, this paper explores how we might revisit and recuperate past academic research projects, theories, and relationships to design futures that matter for social good. As context, I begin by outlining a decade of research in Information and Communication Technologies for Development (ICTD), which linked the United Nations Millennium Development Goals to innovations in telecommunications and computing. I then introduce the ‘theory of design-reality gaps’ that was proposed by Heeks to study ’wicked problems’ in this domain (2002). I revisit two strands of research that I carried out in relation to the ‘design-reality gap’. The first involved an ethnographic study of a participatory mobile phone based learning intervention for Kenyan health workers. I argued that instead of a singular ‘gap’ explained by geographic, sociocultural, or economic ‘divides’, there was a messy entanglement, constituted by sociomaterial practices that enacted a multiplicity (Mol in The body multiple: Ontology in medical practice, Duke University Press, 2002) of desired futures. In the second strand, I attempted to care for the practices that were abandoned by the learning intervention when one kind of justice was prioritized over others. This explored how the research could be more ‘speculative’ and how this ‘speculative commitment’ could generate new ethical questions and logics for living with technology (Puig de la Bellacasa in Social Studies of Science, 41(1), 85–106, 2011 and Matters of care: Speculative ethics in more than human worlds, University of Minnesota Press, 2017). I argue that approaching the design-reality ‘gap’ as a multiplicity instead of a void can support Tuck’s call for educational interventions that turn away from damage oriented theories of change to ones based on desire – approaching difference not as a lack, but as an ever-growing assemblage (2009). Tinkering with the original Heeks model, I conclude that in the postdigital era, the design-reality gap is now better-understood as a fluid space of multiplicities, and what is arguably most pressing is to study the differences in competing objectives and values, rather than disparities in information and technology.
Perception of embodied digital technologies: robots and telepresence systems
Authors: Mandl Sarah , Brade Jennifer , Bretschneider Maximilian , Asbrock Frank , Meyer Bertolt , Jahn Georg , Klimant Philipp , Strobel Anja
Published: October 2023

Embodied Digital Technologies (EDTs) are increasingly populating private and public spaces. How EDTs are perceived in Hybrid Societies requires prior consideration. However, findings on social perception of EDTs remain inconclusive. We investigated social perception and trustworthiness of robots and telepresence systems (TPS) and aimed at identifying how observers’ personality traits were associated with social perception of EDTs. To this end, we conducted two studies (N1 = 293, N2 = 305). Participants rated five different EDTs in a short video sequence of a space sharing conflict with a human in terms of anthropomorphism, sociability/morality, activity/cooperation, competence, and trustworthiness. The TPS were equipped with a tablet on which a person was visible. We found that the rudimentarily human-like TPS was perceived as more anthropomorphic than the automated guided vehicle, but no differences emerged in terms of other social dimensions. For robots, we found mixed results but overall higher ratings in terms of social dimensions for a human-like robot as opposed to a mechanical one. Trustworthiness was attributed differently to the EDTs only in Study 2, with a preference toward TPS and more human-like robots. In Study 1, we did not find any such differences. Personality traits were associated with attributions of social dimensions in Study 1, however results were not replicable and thus, associations remained ambiguous. With the present studies, we added insights on social perception of robots and provided evidence that social perception of TPS should be taken into consideration before their deployment.
Higher education for refugees: relevance, challenges, and open research questions
Authors: Berg Jana
Published: October 2023

Reflecting the increased public, political, and professional interest in higher education for refugees, research activity in this area has increased significantly in recent years. The growing body of literature provides new academic insights and crucial information for both policy and practice. This integrative literature review discusses 104 papers published between 2016 and 2019, contributing to the state of the research by offering a structured synopsis of the key themes and findings of this relatively new field. It first presents structural changes in the research literature, such as an increased focus on Germany and Turkey after the influx of asylum applications in 2015/16. It also outlines the high relevance of higher education for refugees, which is often discussed as the foundation of success in the host country. Further, the paper provides a synopsis of the personal, institutional, and structural challenges faced by refugees as they aim to realize their higher education goals, and an overview of structural challenges for institutions aiming to support them. In particular, the intersection of multiple challenges and the unaligned interests and needs of policymakers, higher education institutions, and refugees threaten the development of adequate support services. Finally, open questions and implications for further research are identified.
Multiscale model reduction for incompressible flows
Authors: Callaham Jared L. , Loiseau Jean-Christophe , Brunton Steven L.
Published: October 2023

We introduce a projection-based model reduction method that systematically accounts for nonlinear interactions between the resolved and unresolved scales of the flow in a low-dimensional dynamical systems model. The proposed method uses a separation of time scales between the resolved and subscale variables to derive a reduced-order model with cubic closure terms for the truncated modes, generalizing the classic Stuart–Landau equation. The leading-order cubic terms are determined by averaging out fast variables through a perturbation series approximation of the action of a stochastic Koopman operator. We show analytically that this multiscale closure model can capture both the effects of mean-flow deformation and the energy cascade before demonstrating improved stability and accuracy in models of chaotic lid-driven cavity flow and vortex pairing in a mixing layer. This approach to closure modelling establishes a general theory for the origin and role of cubic nonlinearities in low-dimensional models of incompressible flows.
Sums of roots
Authors: Braza Peter
Published: October 2023

We are all familiar with the formulae for finding the sums of the powers of the first n natural numbers. For example,
A clock model for planetary conjunctions
Authors: Chebolu Sunil K.
Published: October 2023

On 21 December 2020 the night sky offered a beautiful astronomical treat for stargazers worldwide. An exceptionally rare conjunction of Jupiter and Saturn brought them to 0.1 degrees of angular separation – a fifth of the full moon’s diameter. It marked their closest approach since 1623 and the closest visible conjunction since 1226 (almost 800 years ago!). Astronomy enthusiasts crossed their fingers for clear skies and waited eagerly for this event. The internet and social media were inundated with pictures and news reports, celebrating the great conjunction of our solar system’s two most extensive and majestic planets.
CALCULUS IN INSULAR ARTISTIC DESIGN
Authors: Howlett David
Published: October 2023

This essay considers a mode of thought and a tradition of composition inculcated by four Latin writers, the translator of Anatolius of Laodicea’s De ratione paschali (post ad 283, ante ad 402), Evagrius of Antioch’s translation of Athanasius’s Life of Saint Antony (cad 360–74), Jerome’s Biblia Vulgata (ad 382) and Sulpicius Severus’s Vita Sancti Martini (ad 397), based upon the Life of Antony, and his latercus (ad 410), based upon the work of Anatolius, all texts known in these islands during the period from ad 410–25 to the seventh century. A simple calculus of literary composition in the anonymous Lindisfarne Life of Saint Cuthbert, dedicated to Eadfrith bishop of Lindisfarne in ad 698, is exhibited in the iconographic elements of the Evangelists’ portraits in the Lindisfarne Gospels, written and illuminated by Eadfrith. The same calculus is displayed both in the iconographic designs and in the inscriptions in Northumbrian Old English and Latin on the Franks Casket of cad 700 and on the Ruthwell Cross of cad 730–5.
Proposing a health-specific organizational impact framework to evaluate organizational impacts in health technology assessments
Authors: Mathy Caryn , Pascal Christophe , Bongiovanni-Delarozière Isabelle , Favez Lauriane
Published: October 2023

Objectives

Health technology assessments (HTAs) have traditionally included clinical and cost-effectiveness evaluation of new health technologies (HTs). However, new HTs can generate important organizational impacts (OIs) that influence their overall value. OIs are currently not clearly identified and evaluated in HTA procedures and tools are limited. To address this issue, a comprehensive framework that allows to assess OIs of new HTs in HTAs is proposed.

Methods

A working and methodological group identified the Oslo Manual 2018, 4th edition, OECD/Eurostat, on the objectives and outcomes of commercial innovations as the basis for the OIs framework for HTAs. The Oslo Manual was translated to the healthcare sector and adapted to HTA procedures through a three-step process.

Results

The framework is composed of three main parts. Part I tackles the context of the evaluation, Part II the categories of impacts and the specific impacts – in total, 16 OIs were identified – and Part III the stakeholders involved. The central part of the framework is Part II, and consists of three categories of impacts: (i) on the care process, (ii) on the stakeholders’ capabilities and skills, and (iii) on society or the community.

Conclusions

This framework provides a comprehensive and structured basis to document OIs of new HTs. It thus contributes to the extension of HTA evaluation criteria to other dimensions than clinical and economic aspects, that is, organizational aspects. Some of its intrinsic limitations and the questions they raise in the field for policy-makers, practitioners, and researchers are discussed.
Unmasking the uncommon: bidirectional ventricular tachycardia in two rare paediatric cardiomyopathies
Authors: Sevinc Sengul Fatma , Kafali Hasan Candas , Ergul Yakup
Published: October 2023

We present two exceptional cases of 14-year-old girls diagnosed with rare cardiomyopathies (left ventricular non-compaction, and arrhythmogenic right ventricular cardiomyopathy), both presenting with the unusual finding of bidirectional ventricular tachycardia.
Psychometric Properties of the Trait Meta-Mood Scale (TMMS-23) in the Cuban Context
Authors: Fernández-Castillo Evelyn , Körner Robert , Díaz Guerra Diego D. , Lugo Marena Hernández , Schütz Astrid
Published: October 2023

Abstract: Emotional intelligence (EI) is important for mental health and successful human interaction. We aimed to test the psychometric properties of the Trait Meta-Mood Scale in the Cuban population. In Study 1 ( N = 625), the scale had high internal consistency and the expected three-factor structure. We had to remove one item, as it was negatively correlated with the rest of the items on the scale—resulting in the Cuban TMMS-23. In Study 2 (total N = 240), we tested the scale’s nomological validity: We found that EI had medium-sized positive correlations with extraversion and emotional stability. Negative associations were found between EI and negative affective states. Furthermore, EI was positively correlated with resilience, well-being, optimism, and protective factors for mental health. Thus, the TMMS-23 can be recommended for use in the Cuban context.
Forty years of monitoring increasing sea turtle relative abundance in the Gulf of Mexico
Authors: Lasala Jacob Andrew , Macksey Melissa C. , Mazzarella Kristen T. , Main Kevan L. , Foote Jerris J. , Tucker Anton D.
Published: October 2023

Longitudinal data sets for population abundance are essential for studies of imperiled organisms with long life spans or migratory movements, such as marine turtles. Population status trends are crucial for conservation managers to assess recovery effectiveness. A direct assessment of population growth is the enumeration of nesting numbers and quantifying nesting attempts (successful nests/unsuccessful attempts) and emergence success (number of hatchlings leaving the nest) because of the substantial annual variations due to nest placement, predation, and storm activity. We documented over 133,000 sea turtle crawls for 50.9 km of Florida Gulf of Mexico coastline from 1982 to 2021 for a large loggerhead turtle nesting aggregation and a recovering remnant population of green sea turtles. Over time both species have emerged to nest significantly earlier in the year and green sea turtle nesting seasons have extended. Nest counts and hatchling production for both species have significantly increased, but the rate of emergence success of hatchlings leaving nests has not changed for loggerheads and has declined for green sea turtles. Sea level rise and coastal developments undoubtedly influence coastal habitats in the long-term, impacting nest site selection and potential recruitment from the loss of emerged hatchlings. However, the present indications for steady Gulf of Mexico recovery of loggerhead and green sea turtles counter findings of the Florida Atlantic coasts. This study indicates that effective conservation practices can be detected within time scales of 1–2 turtle generations.
Synthesis of halloysite nanotubes decorated with green silver nanoparticles to investigate cytotoxicity, lipid peroxidation and induction of apoptosis in acute leukemia cells
Authors: Zhang Xuan , Heidari Majd Mostafa
Published: October 2023

Leukemia is the 15th most common cancer in adults and the first most common cancer in children under the age of five, and unfortunately, it accounts for many deaths every year. Since leukemia chemotherapy usually fails due to chemotherapy resistance and disease relapse, many efforts are being made to develop new methods of leukemia treatment. Therefore, for the first time, we decorated halloysite nanotubes (HNTs) with green silver nanoparticles (Ag NPs) with the help of Moringa Peregrina leaves extract to increase the solubility of Ag NPs and to use the protective ability of HNTs against lipid peroxidation in erythrocytes. Cell survival assay by the MTT method showed that HNTs-Ag NPs can decrease the survival of Jurkat T-cells to about 10% compared to the control. The IC50 value was estimated as 0.00177 mg/mL after 96 h of treatment. Investigating the expression of genes involved in apoptosis by Real-time PCR proved that decorated HNTs with Ag NPs can increase the Bak1/Bclx ratio by 17.5 times the control group. Also, the expression of the caspase-3 gene has increased 10 times compared to the control. Finally, the reduction of malondialdehyde production after 24 h proved that the presence of HNTs can have a good protective effect on lipid peroxidation in erythrocytes. Therefore, on the one hand, we can hope for the ability of HNTs-Ag NPs to induce apoptosis in blood cancer cells and on the other hand for its protective effects on normal blood cells.
Systematic integration of m6A regulators and autophagy-related genes in combination with long non-coding RNAs predicts survival in glioblastoma multiforme
Authors: Sharma Amit , Wang Yulu , Ge Fangfang , Chen Peng , Dakal Tikam Chand , Carro Maria Stella , Schmidt-Wolf Ingo G. H. , Maciaczyk Jarek
Published: October 2023

Glioblastoma multiforme (GBM) is probably the only tumor in which a unique epigenetic alteration, namely methylation of the MGMT gene, possesses direct clinical relevance. Now with the emergence of aberrant N6 methyladenosine (m6A) modifications (the most common epigenetic modification of mRNA, closely linked to the autophagy process) in cancer, the epi-transcriptomic landscape of GBM pathobiology has been expanded. Considering this, herein, we systematically analyzed m6A regulators, assessed their correlation with autophagy-related genes (ATG), and established a long non-coding RNAs (lncRNA)-dependent prognostic signature (m6A-autophagy-lncRNAs) for GBM. Our analysis identified a novel signature of five long non-coding RNAs (lncRNAs: ITGA6-AS1, AC124248.1, NFYC-AS1, AC025171.1, and AC005229.3) associated with survival of GBM patients, and four among them clearly showed cancer-associated potential. We further validated and confirmed the altered expression of two lncRNAs (AC124248.1, AC005229.3) in GBM associated clinical samples using RT-PCR. Concerning the prognostic ability, the obtained signature determined high-/low-risk groups in GBM patients and showed sensitivity to anticancer drugs. Collectively, the m6A-autophagy-lncRNAs signature presented in the study is clinically relevant and is the first attempt to systematically predict the potential interaction between the three key determinants (m6A, autophagy, lncRNA) in cancer, particularly in GBM.
Controlling spin pumping into superconducting Nb by proximity-induced spin-triplet Cooper pairs
Authors: Chan A. K. , Cubukcu M. , Montiel X. , Komori S. , Vanstone A. , Thompson J. E. , Perkins G. K. , Kinane C. J. , Caruana A. J. , Boldrin D. , Blamire M. , Robinson J. , Eschrig M. , Kurebayashi H. , Cohen L. F.
Published: October 2023

Proximity-induced long-range spin-triplet supercurrents, important for the field of superconducting spintronics, are generated in superconducting/ferromagnetic heterostructures when interfacial magnetic inhomogeneities responsible for spin mixing and spin flip scattering are present. The multilayer stack Nb/Cr/Fe/Cr/Nb has been shown to support such currents when fabricated into Josephson junction devices. However, creating pure spin currents controllably in superconductors outside of the Josephson junction architecture is a bottleneck to progress. Recently, ferromagnetic resonance was proposed as a possible direction, the signature of pure supercurrent creation being an enhancement of the Gilbert damping below the superconducting critical temperature, but the necessary conditions are still poorly established. Here, we demonstrate that pumping pure spin currents into a superconductor in the presence of an external magnetic field is only possible when conditions supporting proximity-induced spin-triplet effects are satisfied. Our study is an important step forward for pure spin supercurrent creation, considerably advancing the field of superconducting spintronics.
Correction: Synergetic osteogenesis of extracellular vesicles and loading RGD colonized on 3D-printed titanium implants
Authors: Ma Shiqing , Li Xuewen , Hu Han , Ma Xinying , Zhao Zhezhe , Deng Shu , Wang Jie , Zhang Leyu , Wu Chenxuan , Liu Zihao , Wang Yonglan
Published: October 2023

Correction for ‘Synergetic osteogenesis of extracellular vesicles and loading RGD colonized on 3D-printed titanium implants’ by Shiqing Ma et al., Biomater. Sci., 2022, 10, 4773–4784, https://doi.org/10.1039/D2BM00725H.
Stitched peptides as potential cell permeable inhibitors of oncogenic DAXX protein
Authors: Jelinska Clare , Kannan Srinivasaraghavan , Frosi Yuri , Ramlan Siti Radhiah , Winnerdy Fernaldo , Lakshminarayanan Rajamani , Johannes Charles W , Brown Christopher J , Phan Anh-Tuan , Rhodes Daniela , Verma Chandra S
Published: October 2023

Interactions between DAXX and numerous protein interaction partners, along with the autoregulation of a DAXX SUMO Interaction Motif (SIM), can be inhibited by stapled and stitched peptides derived from a minimal DAXX binding peptide found in ATRX.
Ruthenium(II) CNN Pincer Complexes as Efficient Catalysts in Oxidative Annulation of Aromatic Acids with Alkynes to Isocoumarins
Authors: Gayathri Sekar , Kalaipriya Ramajayam , Viswanathamurthi Periasamy , Raju Saravanan , Hrobarik Peter
Published: October 2023

The reaction of [RuHCl(CO)(EPh3)] (E = P or As) with easily accessible N-heteroaromatic-derived hydrazone ligands (L1-2) (L1 = 2-(2-(benzothiazol-2-yl)hydrazono)-1,2-diphenylethanol (BZBT), L2 = 1,2-diphenyl-2-(2-(quinolin-2-yl)hydrazono)ethanol (BZQH)) leads to a novel series of...
Expression of concern: SO2F2-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN)
Authors: Zhao Yiyong , Wei Junjie , Ge Shuting , Zhang Guofu , Ding Chengrong
Published: October 2023

Expression of concern for ‘SO2F2-Mediated one-pot cascade process for transformation of aldehydes (RCHO) to cyanamides (RNHCN)’ by Yiyong Zhao et al., RSC Adv., 2020, 10, 17288–17292, DOI: https://doi.org/10.1039/D0RA02631J.
Impact of urban green and water belts on the city economy: A review of valuation aspects
Authors: Medvedeva Olga , Artemenkov Andrey
Published: October 2023

The purpose of the study is to review available economic methods for the incorporation of urban green belts and water spaces into the city development control system. The paper aims to identify economic subjects of analysis, provide a definition of approaches, and methods for ensuring the rendering of decisions in a monetized form, and outline the main directions of work for creating the legal and methodological frameworks for the formation of urban green belts. The findings indicate that the valuation treatment of urban green water belts requires them to be split into tangible and intangible asset components, with the valuation of the former amenable under the cost approach, and the valuation of the latter requiring the application of sociological (contingent) and regression-based valuation methods. We conclude with suggestions on how valuation estimates obtainable for such assets can be used in the context of urban zoning and financial municipal administration decisions.
Assessment of the possibility of using social network data in urban research
Authors: Uskova Anna , Salomatova Julia , Salomatov Nikita
Published: October 2023

Widespread digitalization leads to the acceleration of socioeconomic processes, which requires faster decision-making. Official statistics is the basis for managing the socio-economic development of a city or region. However, it has a number of limitations related to the timing of publication of information and details. At the same time, new data sources have been emerging in recent years. This study determines the possibility of using open data of the VKontakte social network in socioeconomic research using the example of Russian million-plus cities. The main research methods were statistical, descriptive, and comparative analysis. The information base of the study was made up of depersonalized data of the VKontakte social network users, as well as statistical data. It is revealed that on the basis of depersonalized data from VKontakte, it is possible to characterize the gender and age composition of city residents, which is comparable with Rosstat data, to identify and evaluate labor migration. It is concluded that the data from the social network can be used to obtain analytical information in situations where there is no official statistics available. The data have high geographical detail and can act as an additional source of operational big data on the composition of the population and the quality of its life.
Urban environment monitoring in industrial city using remote sensing of snow cover
Authors: Krupnova Tatyana , Rakova Olga , Kapitonova Tamara , Struchkova Galina , Tikhonova Sardana , Plotnikova Anastasia , Udachin Valerii
Published: October 2023

The dynamic development of modern cities requires new solutions to urban planning and management by local regional authorities. The paper focuses on ecological indicators based on Earth Remote Sensing Data (ERSD) of the snow cover with the purpose to evaluate the city and to plan ecological environment protection strategy. The paper deals with the method of using space images to assess the snow cover pollution of Chelyabinsk, a large Russian industrial city. The assessment of the snow cover of Chelyabinsk was carried out by comparing the heavy metals concentrations with the Landsat 8 data. The spectral indices were calculated for fourteen sites evenly distributed over the urban area of four types: courtyards, car parks, industrial zones and roads. We found a statistically significant difference between the Swirl/Green index and the site type and a correlation with the concentrations of dissolved and suspended forms of heavy metals in snow cover. Snow cover indices can be used as ecological indicators of urban environment.
From degradation to potential urban regeneration? Residents’ perspectives on a historical neighbourhood in Timişoara, Romania
Authors: Camelia Tuţă Adelina , Dragan Alexandru , Creţan Remus
Published: October 2023

Recent studies have indicated that residents’ perceptions on urban neighbourhoods are a multidimensional indicator that refers to an individual’s perception of their own position in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns in various social contexts. Our article makes theoretical and empirical contributions to discussions on the perceptions of residents of a historic neighbourhood and how they experience changes in the the context of postsocialist period. Using a questionnaire launched to Timişoara residents (N=480), in the historic district of Fabric, the findings of our study indicate that the degradation of historical buildings, the living space and living conditions are the main causes of dissatisfaction on the part of residents. Although the advantages of the Fabric neighbourhood are its historical heritage and the central location in Timisoara, the state of decay of the historical buildings and the lack of safety are among the major problems of the neighbourhood identified in the narratives of the respondents.
Labour market and educational potential in Russia’s regions under the conditions of an innovative development vector
Authors: Sydygalieva Begimai , Neklyudova Natalia
Published: October 2023

The paper analyses static data showing improvement in the labor market in all federal districts of Russia in the post-pandemic period, with unemployment rates declining annually. Regarding the leaders among Russian industries in terms of average wages, only two federal districts have changed. In the Northwestern Federal District, information and communication activities have become the most lucrative among other sectors since 2021. In the North Caucasian Federal District, people employed in public administration, military security, and social security have higher average salaries than others do. The winner of the rating of Russian regions in terms of the level of implementation of educational potential in science, mathematics and engineering was Moscow, with St Petersburg coming in second and the Republic of Tatarstan in third place.
Research of labor stress factors in the urban environment: Causes, consequences, prevention
Authors: Kulchitskaya Elena V.
Published: October 2023

Stress is a global problem of modern society. The urban environment creates additional prerequisites for stress, which is confirmed by the study. One of the most common sources of stress is work. In this case, stress is called labour: professional or organizational. These concepts are identical, but there are small nuances in their application regarding the causes of stress. This article analyses the factors of labour stress, its consequences and the possibilities of stress prevention in a modern urban environment. The results of the study of differences in the stress level in different life environments are presented.