bluuebunny/crossref_metadata_2025 huggingface dataset:
Contemporary studies on knowledge, teaching in higher education and social representations in Brazil
Authors: Oliveira Edmila Silva de , Barreto Denise Aparecida Brito
Published: December 2020

This study presents the State of the Art in the research on knowledge, teaching, higher education and social representations. The motivation for this article is based on the relevance of the use of the State of the Art from the references of Ferreira (2002), Messina (1998) and Lakatos (1991), focusing on the main aspects of the collection of work already done. We surveyed the studies that include the descriptors "knowledge, teaching, higher education and social representations" in the Portal of the Coordination for the Improvement of Higher Education Personne - CAPES and then in the Bank of Theses and Dissertations of the Brazilian Digital Library of Theses and Dissertations - BDTD. We select only those works that have a closer relationship with our object - analysis of the social representations of teachers in the Pedagogy Program of a public University in southwest Bahia on teaching in higher education. The purpose of this production is to reveal the objectives, the results and the relationship that the works found and chosen may have with each other. This exercise makes us think about what has been produced in the Post-Graduate Programs in Education-Master Level, the new discussions, as well as reflect on the relevance of our proposal.
Proposta de modelo de avaliação da qualidade direcionado ao Sistema Único de Saúde
Authors: Amoury Neta Alice Silau , Ferreira Brenna Cecília Sousa , Bezerra Rodrigo Rangel Ribeiro , Silva Leonardo Breno Pessoa
Published: December 2020

A avaliação da qualidade direciona esforços para áreas críticas, principalmente quando se fala em gestão de saúde pública, que necessita ser eficiente para o atendimento da população. Neste sentido, ferramentas direcionadas à avaliação da qualidade nesse setor mostram-se pertinentes. Este trabalho teve como objetivo propor um modelo de avaliação da qualidade direcionado ao Sistema Único de Saúde, desenvolvido com base no instrumento Service Quality, e considerando aspectos concernentes ao Institute of Medicine, Programa Nacional de Avaliação dos Serviços de Saúde e à legislação correspondente. Dois instrumentos de coleta foram desenvolvidos e validados estatisticamente por meio do coeficiente alfa para composição do modelo referido. Ao considerar a importância relativa das dimensões sob perspectiva dos três públicos (usuários, profissionais e gestores), a aplicação do modelo SUSSQUAL se mostrou útil para orientação de gestores e/ou profissionais interessados nos processos de tomada de decisões, e no delineamento de estratégias que possuam como fins a elevação qualitativa das atribuições do setor de saúde pública.
Proposta de modelagem de processos para apoiar a implementação do processo de gestão de requisitos do MPS.BR
Authors: Lamonica Barreto Deivison , Rangel de Matos Mariane , F. Garcez Luiz Carlos , Vasconcelos Silva Simone , Pires Vieira de Vasconcelos Aline , Sardinha Cordeiro Morais Alline
Published: December 2020

Destaques: A qualidade de requisitos é de grande importância para o sucesso de um software, tanto em relação ao seu funcionamento quanto aos custos envolvidos no processo de desenvolvimento. A Gerência de Requisitos é um processo importante da engenharia de software e o presente trabalho apresenta uma abordagem sobre a qualidade de requisitos com foco no Processo de Gerência de Requisitos (GRE), presente no nível G do MPS.BR (Melhoria do Processo de Software Brasileiro). O modelo de referência de software do MPS.BR traz os resultados a serem atingidos, porém são de difícil implementação por não apresentarem instruções de como atingir esses resultados. A modelagem de processos, através de modelos visuais, pode ser utilizada como um facilitador para a compreensão e execução destes resultados.

Objetivo: Este trabalho propõe a modelagem das atividades e subprocessos, através da notação BPMN (Business Process Model and Notation), necessária para atingir cada um dos resultados esperados no GRE, onde tal modelagem busca apoiar os profissionais que atuam na implementação do GRE para projetos de desenvolvimento de software.

Metodologia: Encontra-se dividida em quatro etapas: (i) Etapa I - revisão bibliográfica, (ii) Etapa II - análise documental de guias do MPS.BR, (iii) Etapa III – modelagem dos processos através da notação BPMN para a GRE no nível G do MPS.BR, e (iv) validação da modelagem proposta através de pesquisa com profissionais que atuam em áreas relacionadas a TIC (Tecnologia da Informação e Comunicação).

Resultados: A amostra de profissionais que validou os modelos propostos gerou resultados considerados satisfatórios para melhoria da compreensão das atividades necessárias para implantação da gestão de requisitos em projetos de desenvolvimento de software.

Implicações práticas: A principal contribuição prática deste trabalho é facilitar a execução dos resultados esperados do GRE.

Originalidade: a modelagem de processos é proposta como um meio visual para definir as atividades necessárias para se atingir os processos propostos em normas e/ou guias.
Programa de Apoio e Educação em Saúde Ambiental no estado do Amapá: a busca por uma educação ambiental que contribua para a construção de uma sociedade ambientalmente saudável e sustentável
Authors: Pompermayer Fabiana Cunha Leão , Ribeiro Fernandes Jefferson , Shenkel Maria Herminia , Lima Dourado Ximenes Santos Silene , Almeida Marcelo Pompermayer de , Fonseca Estefan Monteiro da
Published: December 2020

A sustentabilidade ambiental é um dos temas mais abordados na atualidade e seus conceitos, sem dúvida, devem ocupar as pautas educacionais. Sua aplicação na educação se mostra de grande importância, uma vez que, a mudança de atitudes referentes ao meio ambiente deve ser proporcionada através das mudanças culturais. Com base nestes preceitos, Universidade Federal Fluminense (UFF) com o apoio da Fundação Nacional de Saúde (FUNASA) executou o Programa de Apoio e Educação em Saúde Ambiental (PAESA). Este programa consistiu na execução de estudos estratégicos voltados à saúde ambiental nas instituições de ensino do Estado do Amapá e atendimento aos povos e às comunidades tradicionais, referente à qualidade da água e seu impacto na saúde da população local. O presente artigo apresenta as dificuldades enfrentadas e aprendizados obtidos através deste projeto abordando os possíveis alcances da sinergia entre a educação infantil e a educação ambiental, buscando um encontro das abordagens teóricas com a prática educativa. Isso foi a grande aposta do PAESA: começar a disseminar a importância de tornar os integrantes das comunidades (escolas etc.) um agente participante na busca por caminhos e estratégias que modifiquem as realidades locais.
PENGARUH MENGIKUTI UNIT BISNIS TERHADAP PENINGKATAN KETERAMPILAN DAN MOTIVASI BERWIRAUSAHA PADA SANTRI
Authors: Anggrayani Deni , Susanto Ari , Al Baqi Safiruddin
Published: December 2020

As education systems, Islamic boarding school has several advantages such as teaching religious knowledge, science and various extracurricular activities. Modern Islamic Boarding School of Darussalam GontorInodonesia is a boarding school that has a holistic education system, which is not only educate the academic skill but also educate students in developing entrepreneurship skills. This study aims to determine the effect of joining the business unit to the motivation and ability of entrepreneurship among students. This research used ethnography method with interviews and observations in business units in Darussalam Gontor. The results of this study indicate that Darussalam Gontoris a boarding school which implements 24-hour education system with various activities, such as praying togather, muajjah, learning in class, sports, mahkamatullughohand others. Differences of Darussalam Gontor with other boarding school is because Darussalam Gontor requires senior student to be responsible for business unit, such as Darussalam Press, Wisma Darussalam, La Tansa bookstore and other units. Result of this study shows that after joining the business unit, students become more motivated to develop their own business. Students also get enough knowledge to start a business or become an entrepreneur. The data showed that many alumni who have success become entrepreneurs. The entrepreneur character is heavily influenced by the role of alumni as a student of Darussalam Gontor. The alumni's businesses include production of songkok, ice cream, bookstore, travel agent, garment businessman and others. Keywords: Business unit, education system, entrepreneurship, Islamic boarding school, Islamic education
KOMPARASI HASIL BELAJAR SISWA MENGGUNAKAN STRATEGI MAKE A MATCH DANCARD SORT MATA PELAJARAN AKIDAH AKHLAK KELAS X MADRASAH ALIYAH
Authors: Zahro’ Faridhotul , Ju’Subaidi Ju’Subaidi
Published: December 2020

The purpose of this study was to find out the difference between student learning outcomes using the make a match strategy and Card Sort strategy in the subjects of AkidahAkhlaq on X grade students in Aliyah Madrasah. This research is a quantitative research with comparative analysis. The subjects of this study were26 X grade studentsof MA M'arifBalong. Data collection used test instruments, while data analysis techniques used the "t" test analysis formula. The results of this study indicate that students who use the make a match strategy were 69.23% in the good category, the sufficient category is 0%, and the less category is 30.77%. While the percentage of learning outcomes of students who use the card sort strategy were 46.15% in the good category, the sufficient category is 0%, and the less category is 53.85%. This shows a significant difference between student learning outcomes using the strategy to make a match and card sort strategy. It is proven by the test "t" obtained t0 = 50.55 at a significant level of 1% tt = 2.80 and at a significant level of 5% tt = 2.06 so that t_0>t_t means Ha is accepted. It means a strategy of making a match is suitable for AkidahAkhlaq because it can improve student learning outcomes while the card sort strategy is not suitable for use in AkidahAkhlaq.Keywords:Learning outcome, make a match strategy, card sort strategy, subject of akidah akhlaq.
Um século de doenças infectocontagiosas
Authors: Andrade Clarissa Dias Rodrigues , Lopes Guilherme Augusto Hilário
Published: December 2020

O presente texto busca relatar as experiências desenvolvidas no campo da iniciação científica e os seus desdobramentos, como a participação de feiras científicas. Adicionalmente, compartilha os processos necessários para a elaboração da pesquisa e as etapas requeridas para a participação na V Mostra Científica do Cariri. Ainda, “Um século de doenças infectocontagiosas: A História de um Brasil contaminado”, busca narrar os fatos ocorridos durante o período da República no Brasil nos campos sociais, político, econômico e de saúde pública. Por fim, o trabalho desenvolvido buscou chamar a atenção dos brasileiros e das autoridades públicas para a forma com que surtos de doenças determinam as relações de poder e de convivência em uma sociedade.
O saber da química pela visão lúdica: dois objetos educacionais como ferramentas instrucionais
Authors: Martins Medeiros Jacilene , Xavier Baliza Patrícia , Fernandes Amaral Héber , Chaves Sicupira Lázaro , Moreira Bittencourt Rigueira Leila
Published: December 2020

A dificuldade em interpretar questões de Química, principalmente as que envolvem conceitos matemáticos, o que muitas vezes exige que o aluno tenha conhecimento prévio de conceitos químicos, e a abstração dos conteúdos da disciplina, são alguns dos problemas apontados pelos alunos e professores do Ensino Médio. Esses problemas resultam no desinteresse dos alunos pela disciplina e a consequente diminuição da qualidade do ensino de Química, além de uma taxa maior de evasão de estudantes. Com a ascensão de novas tecnologias, que facilitam cada vez mais a vida cotidiana, os educadores começaram a refletir sobre como utilizá-las no processo de ensino e aprendizagem. Este artigo apresenta o estudo de dois Objetos Educacionais (OEs) de Química, o jogo quiz e o jogo da memória, desenvolvidos para o ambiente web. A finalidade deste trabalho é mostrar que, ao usar os OEs, os discentes passam a ter um interesse maior pela disciplina, e que estes objetos são uma ótima ferramenta para a melhoria do ensino e aprendizagem de Química, complementando as aulas teóricas. A metodologia empregada foi dividida em seis fases: concepção, elaboração, desenvolvimento, testes, aplicação e levantamento dos resultados. Aplicados a 81 alunos dos segundos e terceiros anos do Ensino Médio, os jogos tiveram uma aceitação de 78% e, após avaliações feitas, os resultados apontaram que houve uma melhora considerável na aprendizagem de Química.
Requalificação da mão de obra: atuação do Programa Construção +
Authors: de Jesus Lourenço Graziele , Ferreira de Rezende Costa Iara , De Oliveira Costa Neto Alcino , Alves Rodrigues Josilane , Letícia Silva Carvalho Sílvia , de Souza Ferreira Ana Letícia , Cristine Lima Sales Daiana
Published: December 2020

O conceito de qualificação profissional está em evidência no cenário da construção civil. É preocupação notória, tendo em vista que durante muito tempo houve preferência das empresas pela contratação de profissionais com pouca qualificação por apresentarem baixa pretensão salarial. De acordo com a Globaltec (2017), mais de 70% das empresas vinculadas à construção civil encontram entraves que dificultam a contratação de profissionais capacitados para a execução de suas obras. Nesta perspectiva, irrompem programas universitários direcionados à capacitação da mão de obra deste mercado, com o intuito de contribuir para minimização deste déficit, que ainda é realidade no país. O Construção+ é um programa que alia ensino, pesquisa e extensão, desenvolvido na cidade de Teófilo Otoni, em Minas Gerais. Propõe como seu objetivo primordial a requalificação da mão de obra da construção civil da região por meio do fornecimento de aulas teóricas e práticas gratuitas. Além da abordagem técnica a respeito de temas do cotidiano dos profissionais inscritos nos cursos, busca-se promover a troca de experiências que sejam enriquecedoras do conhecimento prático dos cursistas, bem como o embasamento teórico dos facilitadores. Essas trocas ocorrem, muitas vezes, por meio de informações de procedimentos executivos no canteiro de obras e no surgimento de novas metodologias no setor da construção civil.
Correlation Between MRI Findings and Clinical Impairment In Patients With Shoulder Adhesive Capsulitis: A Prospective Study
Authors: GILLET Romain , ZHU Francois , PADOIN Pierre , HOSSU Gabriella , RAUCH Aymeric , TEIXIERA Pedro Augusto GONDIM , BLUM Alain
Published: December 2020

Objectives:

MRI diagnostic criteria of shoulder adhesive capsulitis (AC) are widely used, but there is little information available on the association between MRI findings and clinical impairment. The aim of our study was to determine the correlation of MRI findings with the Constant-Murlay Score (CMS), pain duration, and symptoms at the one-year follow-up in AC patients.
Methods:

MRI of 132 patients with a clinical diagnosis of shoulder AC were prospectively studied. A radiologist examined all patients and completed the CMS just prior to MRI. Pain duration was assessed. The signal intensity and the maximal thickness of the inferior glenohumeral (IGHL) and coracohumeral (CHL) ligaments were measured by two radiologists. Medical record analysis was performed in a sub-group of 49 patients to assess correlation approximately one year after the MRI examination.
Results:

There was a significant difference in mean pain duration score (3.8 ± 1.2 versus 3.2 ± 0.9 and 3.8 ± 1.2 versus 3.2 ± 0.9 respectively for readers 1 and 2) and in mean mobility scores (15.7 ± 8 points versus 19.6 ± 10.1 points and 15.8 ± 8.2 points versus 19.4 ± 10 points respectively for readers 1 and 2) in patients with a high IGHL signal compared to those with a low signal (P < .05). IGHL was thicker in patients with clinical improvement at one-year follow-up compared to those presenting clinical stability or worsening (P < .05).
Conclusion:

In shoulder AC patients, the degree of signal intensity at the IGHL was inversely related to shoulder pain duration and range of motion, and a thickened IGHL indicated a favorable outcome at one-year follow-up.
Life Expectancy of Older People Living in Aged Care Facilities after a Hip Fracture
Authors: Liu Enwu , Killington Maggie , Cameron Ian , Li Raymond , Kurrle Susan , Crotty Maria
Published: December 2020

Little is known about life expectancy in nursing home residents with hip fracture. We assessed life expectancy of 240 residents of residential aged care facilities who were aged more than 70 years old and experienced recent hip fracture treated with surgery. 149 deaths occurred over a mean follow-up of 1.2 years. Being female (coefficient (β) = 0.86, 95% confidence interval (CI): 0.39, 1.34; p = 0.0004) was associated with longer life expectancy. Increased age was associated with shorter life expectancy (β=-0.06, 95% CI: -0.10 to -0.02, p = 0.0043). Relative to severe cognitive impairment, normal or mild-cognitive impairment (β = 1.18, 95% CI: 0.05 to 2.31, p = 0.0414) and moderate cognitive impairment (β = 0.56, 95% CI: 0.07 to 1.04, p = 0.0237) were associated with longer life expectancy. Mortality rate within three months after hip fracture was 118 cases per 100 person-years while the mortality rate for the whole study period was 51.3 deaths per 100 person-years. For females with hip fracture, life expectancy was 8.2 years at 70 years of age; 4.8 years at 80 years of age; and 2.8 years at 90 years of age. For males with hip fracture, life expectancy was 3.8 years, 2.2 years and 1.3 years at 70, 80 and 90 years of age, respectively.
WITHDRAWN: IL-31, IL-32 and IL-33 may Serve as Diagnosis Biomarkers in Gastric Cancer
Authors: Bao Shisan , Liu Qinghua , Zhang Jiwei , Xia Lei , Wise Steven , Hambly Brett , Tao Kun
Published: December 2020

Background: To determine whether IL-31, IL-32 and IL-33 can be used as biomarkers for the detection of gastric cancer (GC), via evaluating the correlations between IL-31, IL-32 and IL‑33 expression and clinicopathological parameters of GC patients.Methods: Tissue array (n=180) gastric specimens were utilised. IL-31, IL-32 and IL-33 in GC and non-GC tissues were detected immunohistochemically. The correlations between IL-31, IL-32 and IL-33 in GC and severity of clinicopathological parameters were evaluated. Survival curves were plotted using the Kaplan-Meier/Cox regression. IL-31, IL-32 and IL-33 in circulation were detected by ELISA. Results: IL-31, IL-32 and IL-33 were all lower in GC than that in adjacent non-GC gastric tissue (p all <0.05). IL-33 in peripheral blood of GC patients was significantly lower than that of healthy individuals (1.50 ± 1.11 vs 9.61 ± 8.00 ng/ml) (p<0.05). Decreased IL-31, IL-32 and IL-33 in GC were observed in younger patients (<60 years), and IL-32 and IL-33 were lower in female patients (p all <0.05). Higher IL-32 correlated with longer survival in two GC subgroups: T4 invasion depth and TNM I-II stage. Univariate/multivariate analysis revealed that IL-32 is an independent prognostic factor for GC within the T4 stage subgroup. Circulation IL-33 was significantly lower in GC patients than healthy people (p <0.05). Conclusions: Our findings provide new insights into the roles of IL-31, IL-32 and IL-33 in carcinogenesis of GC and demonstrate their relative usefulness as prognostic markers for GC. The underlying mechanism of IL-31, IL-32 and IL-33 in GC is further discussed.
Development of N6-methyladenosine Related Signature as New Biomarker for Prognosis of Hepatocellular Carcinoma and Correlates with Sorafenib and anti-PD-1 Immunotherapy Treatment Response
Authors: Jiang Hong-ye , Ning Gang , Wang Yensheng , Lv Wei-biao
Published: December 2020

Background: N6-methyladenosine (m6A) modification plays an essential role in diverse key biological processes and may take part in the development and progression of hepatocellular carcinoma (HCC). Here, we systematically analyzed expression profiles and prognostic values of 13 widely reported m6A modification related genes in HCC.Methods: mRNA expression of 13 m6A modification related genes and clinical parameters of HCC patients were downloaded from TCGA, ICGC, GSE109211 and GSE78220. Univariate and LASSO analysis was used to develop risk signature. Time-dependent ROC was performed to assess the predictive accuracy and sensitivity of risk signature.Results: FTO, YTHDC1, YTHDC2, ALKBH5, KIAA1429, HNRNPC, METTL3, RBM15, YTHDF2, YTHDF1 and WTAP were significantly overexpressed in HCC patients. YTHDF1, HNRNPC, RBM15, METTL3, YTHDF2 were independent prognostic factors for OS and DFS in HCC patients. Next, a risk signature was also developed and validated with five m6A modification related genes in TCGA and ICGC HCC cohort. It could effectively stratify HCC patients into high risk patients with shorter OS and DFS and low risk patients with longer OS and DFS and showed good predictive efficiency in predicting OS and DFS. Moreover, significantly higher proportions of macrophages M0 cells, neutrophils and Tregs were found to be enriched in HCC patients with high risk score, while significantly higher proportions of memory CD4 T cells, gamma delta T cells and naive B cells were found to be enriched in HCC patients with high low score. Finally, significantly lower risk scores were found at sorafenib treatment responders and anti-PD-1 immunotherapy responders compared to that in non-responders, and anti-PD-1 immunotherapy treated patients with lower risk score had better OS than patients with higher risk score. Conclusion: A risk signature developed with the expression of 5 m6A related genes could improve the prediction of prognosis of HCC and correlate with sorafenib treatment and anti-PD-1 immunotherapy response.
Absence of miR-378d Promoted The Malignant Phenotype of ESCC Through The AKT-β-Catenin and Hippo-p53 Signaling Pathway
Authors: Peng Jie , Yu Juan , Liu Jianli , Wei Haixiang , Song Haixia , Shi Susu , Wang Shaoqiang , Guo Daolu , Li Zhejie , He Shujin , Feng Xi , Li Lei , Zhao Ran , Liu Yukun , Liu Yanrong , Li Junjun , Zhang Renya , Wang Wei
Published: December 2020

Background: Chemoresistance is an important cause of malignant progression of esophageal squamous cell carcinomas (ESCCs). miR-378d is sharply reduced in paclitaxel (PTX)-resistance esophageal cancer cells by gene-expression profile analysis (RNA-Seq), but the mechanism of miR-378d-mediated tumor progression is unclear. Patients and methods: Herein, we detected miR-378d expression in 596 ESCC patients by in situ hybridization. Results showed that low miR-378d expression was associated with poor prognosis of ESCC patients, and that miR-378d absence enhanced carcinogenesis by promoting chemoresistance, colony formation, EMT, invasion, and metastasis. Results: Furthermore, miR-378d can target downregulated AKT1 expression by binding to the AKT1 mRNA 3′UTR, inactivating the AKT-β-catenin signaling pathway, and reducing the epithelial–mesenchymal transition marker Vimentin and the cancer stem cell marker ALDH1A1. miR-378d silencing in ESCC cells also promoted polyploidy formation in vitro and in vivo, and miR-378d inhibition suppressed the Hippo-p53 signaling pathway. Consequnetly, YAP and TAZ protein accumulated in nuclei and p53 expression decreased, which may promote the formation of ploidy tumor cells. Conclusions: Therefore, low miR-378d expression is a poor prognostic factor of ESCC patients and promotes polyploidy and cancer progression by activating AKT-β-catenin and suppressing the Hippo-p53 signaling pathway.
Anthropometric and Dietary Indicators Applied in Population-based Surveys: a Systematic Review.
Authors: Cabral Natalia , Pequeno Nila , Silva David , Crispim Sandra , Marchioni Dirce , Lima Severina , Lyra Clelia
Published: December 2020

Background: Anthropometric and food consumption indicators are important in dietary, nutritional, and health status conditions assessment and monitoring of the population, as a mechanism to identify changes or trends in consumption and to understand the relationship between dietary exposure and varied health outcomes. The aim was to identify population-based health and nutrition surveys, conducted with adults and the elderly, and performed in the Americas, Europe, and Oceania, in order to investigate the more common anthropometric and food consumption methods used, their applicability, and their limitations. Methods: Electronic databases (LILACS, PubMed, and SCOPUS) were systematically searched for studies published between 1997 and 2017 in Portuguese, English or Spanish. Forty-five studies (49% carried out in the Americas) met the eligibility criteria and were included in the review. The data were analysed in 2018. Results: The methodological quality of most of the studies (64.4%) was classified as moderate, according to the Agency for Healthcare Research and Quality checklist for cross-sectional studies and the Newcastle-Ottawa scale for cohort studies. Forty percent of the articles evaluated only food consumption, 31% just anthropometry, while 29% evaluated food consumption and anthropometric measurements. The most used food survey methods were food record (31% of studies) and the 24-hour dietary recall (22% of studies). Body mass index (BMI) was the most used indicator for anthropometric nutritional status assessment. Although most of the studies used the World Health Organization classification criteria, these studies did not adopt the different cut-off points for BMI classification for adults and the elderly. Conclusion: BMI and methods that record current consumption, such as the food record and the 24-hour dietary recall, were the main methods of assessing nutritional status, taking into consideration the easy application, low cost, and good reproducibility.Systematic Review Registration: PROSPERO CRD42017071392
Effects of Polyunsaturated Fatty Acids Supplementation on The Meat Quality of Pigs: A Meta-Analysis
Authors: Wang Liyi , Huang Yuqin , Shan Tizhong
Published: December 2020

Background: Polyunsaturated fatty acids (PUFAs) supplementation has been widely discussed as a strategy for improving meat quality in pig production but the effects are inconsistent. This meta-analysis was performed to comprehensively evaluate its effects on the meat quality including intramuscular fat (IMF) content, drip loss, meat color, pH 45min and pH 24h of pigs.Methods: We searched the PubMed and Web of Science databases (articles published from Jan 1st, 2000, and Oct 16th, 2020) and compared PUFAs-supplemented diets with control diets. We identified 1670 studies, of which 14 (with data for 752 pigs) were included in our meta-analysis. We used a random-effects model and a fixed-effects model to calculate the weighted mean differences (WMDs) and 95% confidence intervals (CIs). We used sensitivity and subgroup analysis to ensure the pooled estimates are robust. The subgroup analysis was classified as treatment (conjugated linoleic acid (CLA) or linseed), concentration (high or low concentration) and initial stage (growing and finishing pigs).Results: Our analysis found that PUFAs supplementation increased the IMF content (WMD= 0.467%, 95% CI: 0.312 to 0.621, P<0.001), decreased the meat color L* (WMD= -0.636, 95% CI: -1.225 to -0.047, P=0.034) and pH 24h (WMD= -0.021,95% CI: -0.032 to -0.009, P<0.001). CLA supplementation improved IMF content (WMD= 0.542%, 95% CI: 0.343 to 0.741, P<0.001) and reduced meat color b* (WMD= -0.194, 95% CI: -0.344 to -0.044, P=0.011). Linseed supplementation increased IMF content (WMD= 0.307%, 95% CI: 0.047 to 0.566, P=0.021), decreased meat color L*(WMD= -1.740, 95% CI: -3.267 to -0.213, P=0.026) and pH 24h (WMD= -0.034, 95% CI: -0.049 to -0.018, P<0.001). We discovered an increase on IMF content in both high and low concentration PUFAs supplementation (WMD= 0.461%, 95% CI: -0.344 to -0.044, P<0.001; WMD= 0.456%, 95% CI: 0.276 to 0.635, P<0.001). Besides, we also found the effects of PUFAs supplementation on meat color L* and pH 24h are concentration- and stage-dependent.Conclusions: PUFAs supplementation can improve meat quality of pigs which mainly emerge in greatly increasing IMF content.
Effect of preoperative information about pain on postoperative pain experience and patient satisfaction following orthopaedic surgery: A randomised controlled trial.
Authors: Othin Moses , Sendagire Cornelius , Mukisa John , Lubulwa Clare , Mulepo Phillip , Wabule Agnes , Ayebale Emmanuel
Published: December 2020

Background: Preoperative information about pain has been shown to improve postoperative pain perception and reduce postoperative analgesia requirements. However, there is limited data regarding the effect of preoperative counselling in low resource settings. This study aimed at assessing the effect of preoperative information about pain on postoperative pain experience measured as postoperative pain using a verbal numerical rating scale (VNRS) and patient satisfaction with pain management. Methods: A randomised, double blind, controlled trial was done in Mulago National Referral Hospital (MNRH), Kampala. We prospectively enrolled 400 participants aged 18years and above scheduled for elective orthopaedic surgery. The consented patients were randomised to either receive the specific preoperative information about pain or not. The primary end points were postoperative pain score and patient satisfaction. A total of 340 were analysed with 170 in either arm. Secondary analyses where done to determine the factors that were associated with postoperative pain and patient satisfaction.Results: In both arms, the lowest pain score was 0/10 at 0 hours and the highest was 7/10 at 12 hours. A statistically significant difference between the intervention and control arms for the median pain score at 48hours (4/10 vs. 5/10) P-value= 0.029 was seen but none at 0, 12, 24hours. There was no difference in satisfaction with pain management (P value=0.059). Conclusion: Preoperative information about pain improves postoperative pain experience and may negatively impact patients’ satisfaction with pain management due to unmet expectations.Trial registration: Clinicaltrials.gov, NCT03056521. Registered 17 February 2017 - Retrospectively registered, https://clinicaltrials.gov/ct2/show/NCT03056521
Outcomes of reduction hepatectomy and postoperative multidisciplinary therapy for 30 unresectable advanced hepatocellular carcinomas
Authors: Asahi Yoh , Kamiyama Toshiya , Kakisaka Tatsuhiko , Orimo Tatsuya , Shimada Shingo , Nagatsu Akihisa , Sakamoto Yuzuru , Kamachi Hirofumi , Taketomi Akinobu
Published: December 2020

Background

The role of volume reduction hepatectomy in the treatment of unresectable advanced hepatocellular carcinoma remains unclear. This study aimed to examine the outcomes of combination treatment with reduction hepatectomy and multidisciplinary postoperative treatment for unresectable advanced hepatocellular carcinoma.
Methods

Thirty cases of unresectable advanced hepatocellular carcinoma, in which reduction hepatectomy was performed between 2000 and 2018 at the Department of Gastroenterological Surgery I, were divided into POCR(+) and POCR(-) groups, depending on whether postoperative complete remission (POCR) of the evaluable lesions was achieved through postoperative treatment. The cases in the POCR(-) group were subdivided into POCR(-)TKI(+) and POCR(-)TKI(-) groups, depending on whether tyrosine kinase inhibitors (TKIs) were administered postoperatively.
Results

The 5-year overall survival rate and mean survival time (MST) after reduction hepatectomy were 15.7% and 28.40 months, respectively, for all cases; 37.5% and 56.55 months, respectively, in the POCR(+) group; and 6.3% and 14.84 months, respectively, in the POCR(-) group (p = 0.0041). Tumor size, vascular invasion, and the number of tumors in the remnant liver after the reduction hepatectomy were also found to be related to survival outcomes. The number of tumors in the remnant liver was the only factor that differed significantly between the POCR(+) group and POCR(-) group, and POCR was achieved significantly more frequently when ≤ 3 tumors remained in the remnant liver (p = 0.0025). The MST was 33.52 months in the POCR(-)TKI(+) group, which was superior to the MST of 10.74 months seen in the POCR(-)TKI(-) group (p = 0.0473).
Conclusions

Reduction hepatectomy and multidisciplinary postoperative treatment for unresectable advanced hepatocellular carcinoma resulted in a 5-year overall survival rate of 15.70% and an MST of 28.40 months. The treatment strategy was effective when POCR was achieved via multidisciplinary postoperative therapy. To achieve POCR, reduction hepatectomy should aim to ensure that ≤ 3 tumors remain in the remnant liver. Even in cases in which POCR is not achieved, combined treatment with reduction hepatectomy and multidisciplinary therapy can improve survival outcomes when TKIs are administered.
Identification of molecular markers associated with the progression and prognosis of lung adenocarcinoma:a bioinformatic study
Authors: Du Kexin , Wang Xioahan
Published: December 2020

Objective: For the identification of genes of prognostic significance related to tumor microenvironment (TME) in lung adenocarcinoma.Methods and Materials: Transcriptome data and clinical data of lung adenocarcinoma originated from the Cancer Genome Atlas (TCGA) database. Immune scores and stromal scores were calculated by “Estimation of Stromal and Immune cells in Malignant Tumors using Expression data” algorithm. Based on these calculated scores, the samples were classified as high and low score groups. The average score of respective gene in different groups was calculated. A heat map was created to screen out genes exhibiting differential expressions. The interaction of up-regulated differentially expressed genes (DEGs) and down-regulated DEGs was harvested from a Venn diagram and then covered in the overlapping genes. The core genes influencing prognosis of lung adenocarcinoma were screened out by function enrichment analysis, protein-protein interaction network analysis and Kaplan-Meier (K-M) method on the overlapping genes.Results: A total of 515 samples of lung adenocarcinoma were harvested from TCGA database. As revealed from the results, a high immune score was related to a high survival rate, while the matrix did not show significant relationships to survival rate. A total of 775 DEGs and 367 overlapping genes were harvested. The functions of these overlapping genes were tightly correlated with DEGs and immune response and were noticeably improved in cytokine-cytokine receptor interaction and chemokine signaling pathway. Eight genes, namely, CCR5, CCR2, CCL14, GNRH2, PKHD1L1, MS4A1, FCER2 and FDCSP, were correlated with prognosis of lung adenocarcinoma.Conclusion: The genes and pathways affecting prognosis of lung adenocarcinoma were screened out, which offer ideas for subsequent study on lung adenocarcinoma.
Alterations of the Gut Microbiome and Metabolome in Patients with Proliferative Diabetic Retinopathy
Authors: Yao Ke , Ye Panpan , Zhang Xueyou , Xu Yufeng , Xu Jia , Song Xiaoxiao
Published: December 2020

Background: Diabetic retinopathy (DR) has been reported to associate with gut microbiota alterations in murine models and thus “gut-retina-axis” has been proposed. However, the role of gut microbiome and the associated metabolism in DR patients still need to be elucidated. Results: Fecal samples from 45 patients with proliferative DR (PDR) and 90 matched diabetic patients (1:2 according to age, sex and duration of diabetes) without DR (NDR) were subjected to 16S rRNA gene sequencing and untargeted metabolomics. Significantly lower bacterial diversity was observed in PDR group than that in NDR group. Differential gut bacterial composition was found, with significant depletion of 22 families (e.g., Coriobacteriaceae, Veillonellaceae and Streptococcaceae) and enrichment of 2 families (Burkholderiaceae and Burkholderiales_unclassified) in PDR group as compared to NDR group. There were significantly different fecal metabolic features, which were enriched in metabolic pathways such as arachidonic acid and microbial metabolism, between the two groups. Among 36 co-abundance metabolite clusters, 11 were positively/negatively contributed to PDR using logistic regression analysis. Fifteen gut microbial families were significantly correlated with the 11 metabolite clusters. Furthermore, a fecal metabolites-based classifier was constructed to distinguish PDR patients from NDR patients accurately.Conclusions: PDR is associated with reduced diversity and altered composition of gut microbiota and specific microbe-metabolite interplay. Our findings help to better understand the disease pathogenesis and provide novel diagnostic biomarkers and therapeutic targets for PDR.
Towards a Smart GIS Public Health Record System for the Capital Governorate, State of Kuwait
Authors: Aziz Mohamed Alkhuzamy , Al-Helal Huda Ibrahim
Published: December 2020

Health care services are considered the sign of a contemporary civilized society, reflecting its level of modernity. A study of the developmental stages and location variables of health care services can facilitate understanding location characteristics for a progressive perspective to achieve optimal standards of health care service. This study focuses on the 17 public health centers located within the districts of the Capital Governorate, State of Kuwait. The scientific methodology that is used in this study is based on a spatial and geo-statistical analysis of public health centers. The results of this applied analysis highlight the inadequacies of the current management system running public health facilities in the State of Kuwait. The study seeks to create a new system based on GIS technology dubbed “Public Health Record Information System”. The proposed system would not only rectify patient health record errors, but also improve the overall health management process.
A Label-Free Proteomic Strategy to Investigate the Intramuscular fat Proteomic Differences Between Biceps Femoris and Longissimus Dorsi in Inner Mongolian Cashmere Goats
Authors: Xie Yuchun , Liu Zhihong , Nai Rile , Guo Juntao , Su Xin , Zhao Cun , Zhang Chongyan , Qin Qing , Dai Dongliang , Wang Zhixin , Zhao Yanhong , Su Rui , Wang Zhiying , Wang Ruijun , Zhang Yanjun , Li Jinquan , Li Haijun
Published: December 2020

Background: As a major raw-cashmere-producing province in China. Nearly 700,000 Aerbasi cashmere goats are fed per year, and the corresponding meat production is nearly 10,000 tons. However, there are no reports on the meat of this goat. To better understand the molecular variations underlying intramuscular fat (IMF) anabolism and catabolism in Inner Mongolian cashmere goats, the proteomic differences between the biceps femoris (BF) and longissimus dorsi (LD) were investigated by a label-free strategy. Then, the identified proteins were verified as being involved in IMF anabolism and catabolism by Western blot analysis.Results: The IMF content was significantly higher in the BF than in the LD, suggesting that IMF accumulated more in the BF or was metabolized more in the LD. We performed proteomic analysis of IMF anabolism and catabolism at the proteomic level, and 1209 proteins were identified in the BF (high-IMF) and LD (low-IMF) groups. Among them, 110 were differentially expressed proteins (DEPs), 81 of which were upregulated in the high-IMF group, while 29 were upregulated in the low-IMF group. Gene ontology (GO) classification showed that the 110 DEPs were functionally classified into 100 annotation clusters. Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that the 110 DEPs covered 34 KEGG pathways. Three pathways were related to IMF metabolism and deposition—fatty acid metabolism, fatty acid degradation and fatty acid elongation—and included 7 proteins.Conclusion: GO and KEGG analyses showed that differentially expressed HADHA, HADHB, ACSL1, ACADS, ACAT1 and ACAA2 in the mitochondria act via fatty acid metabolism, fatty acid degradation and fatty acid elongation to influence the metabolism and synthesis of long-, short- and medium-chain fatty acids and modulate IMF anabolism and catabolism. Protein-protein interaction (PPI) network analysis showed that IMF accumulation in different muscle tissues of Inner Mongolian cashmere goats was affected not only by 5 key enzymes and proteins involved in fatty acid synthesis and metabolism but also by five DEPs (SUCLG1, SUCLG2, CS, DLST, and ACO2) in the TCA cycle. Our results provide new insights into IMF deposition in goats and improve our understanding of the molecular mechanisms underlying IMF anabolism and catabolism.
Metagarantía como telhos del derecho a la seguridad social. Un análisis desde la metafísica aristotélica
Authors: Ramírez César Augusto , Santana Londoño María Victoria
Published: December 2020

En el desarrollo de esta propuesta se abarcan tres enfoques de análisis en los que se consideró, en primer lugar, la dimensión axiológica de la constitucionalización del derecho a la seguridad social, en que se abarca históricamente cómo se han venido desarrollando importantes estudios sobre el impacto que ha tenido la constitucionalización del derecho. En segundo lugar, la dimensión de la constitucionalización del derecho a la seguridad social, en el que se procura exponer este concepto bajo la mirada de un Estado constitucional contemporáneo. Y, por último, se presenta desde una reflexión metafísica en Aristóteles, que importantes principios del derecho pueden encontrar su fundamentación en la filosofía, motivo por el cual encuentra su aceptación o justificación en su propia naturaleza, consistente en precisar aquello que constituye el contenido esencial para lo cual es pensada una garantía.
Taxonomía contable
Authors: Rincón Soto Carlos Augusto , Lemos de la Cruz Jorge Eduardo
Published: December 2020

El concepto de taxonomía, es un tipo de saber profundizado por la biología, bibliotecología, educación, informática, entre otras disciplinas, para ordenar, catalogar, manipular y revelar sus saberes. No obstante, este concepto que ha sido escasamente abordado por la teoría contable, a pesar de su aplicación fundamental en el proceso de ordenación y revelación de la información. La taxonomía contable es utilizada por los organismos emisores de normas contables, para materializar las políticas de revelación. Este trabajo busca desde una metodología hermenéutica-fenomenológica desocultar el concepto para interpretarlo y comprenderlo por medio de las reglas de la teoría de conjuntos, lo que permite acercarse a explicar la estructuración de los informes contables en su revelación tradicional isomórfica dual.
El potencial pedagógico del Estudio de Caso mediante el uso del e-portfolio y la e-rúbrica: una experiencia interdisciplinar
Authors: García-Zabaleta Esther , Díez-Gómez Adriana , Santiago Campión Raúl , Valdemoros San Emeterio Mª Ángeles
Published: December 2020

El objetivo del presente artículo fue examinar el potencial pedagógico del Estudio de Caso, a través del uso del e-portfolio y la e-rúbrica, para el fomento del trabajo interdisciplinar en la formación inicial del profesorado. Para ello, se trabajó como temática compartida de tres asignaturas del grado de Educación Primaria, mediante el Estudio de Caso, “la acción tutorial del docente”, desde una triple perspectiva: el rol y funciones del docente, las expectativas del profesorado y la tutoría entre iguales, enmarcada como proyecto de innovación. Utilizando la e-rúbrica como método de evaluación, los resultados encontrados fueron que, de manera general, a través del Estudio de Caso, el alumnado es capaz de integrar de manera comprehensiva y global los contenidos de las diferentes materias trabajadas. Asimismo, se evidenció la relación entre una mayor integración de contenidos con más alusiones a aspectos emocionales, así como con un mejor uso de herramientas digitales. Estos resultados avalan la eficacia del Estudio de Caso, evaluado mediante herramientas digitales, en el trabajo interdisciplinar y en la adquisición de competencias.
El aprendizaje adaptativo para la regularización académica de estudiantes de nuevo ingreso: la experiencia en un curso remedial de matemáticas
Authors: López Cynthia , Bedolla Cornejo Ligia Patricia
Published: December 2020

El presente artículo describe una investigación que la Dirección de Innovación Educativa del Tecnológico de Monterrey realizó sobre la incorporación del aprendizaje adaptativo en un curso remedial “Introducción a las matemáticas”, el cual sirve para regularizar en conocimientos básicos a los estudiantes de nuevo ingreso, en este caso en matemáticas, llevada a cabo durante el semestre agosto-diciembre de 2018 con el objetivo de analizar el impacto del aprendizaje adaptativo en la experiencia y rendimiento académico del estudiante. Se realizó una investigación descriptiva transeccional con enfoque mixto. Se utilizó una encuesta semiabierta y la recolección de calificaciones. Se contó con una muestra representativa de 919 estudiantes de 15 campus. Los resultados indicaron un alto grado de satisfacción con la experiencia de enseñanza-aprendizaje adaptativa y se identificó un impacto positivo en el rendimiento académico de los estudiantes.
Co-designing Research Methods Lesson Plans in the Interactive Research Methods Lab
Authors: Jorrín Abellán Ivan M. , Vasquez Anete , Gaines Rachel E.
Published: December 2020

In this article we present a series of co-design sessions conducted throughout the 2019-2020 academic year, of which the aim was to plan and implement lessons on research methods for undergraduate and graduate students in the Interactive Research Methods Lab (IRML). The IRML is a brand new resource in the Bagwell College of Education (Kennesaw State University) that provides students with personalized instruction and practical experience in generating research designs, conceptual frameworks, and reviews of literature using Augmented Reality (AR) interactive contents.  We followed the seven characteristic features of co-design as outlined by Roschelle et al. (2006) and structured sessions for co-design in accordance with Cober et al. (2015) and Barberá et al.’s (2017) proposed stages:  a) Exploration, b) Envisioning, c) Operationalization, and d) Assessment and Reflection.

Successful implementation of the co-designed lessons and their integration with the IRML as a technological learning resource highlight the affordances of using a co-design approach to confront the inherent challenges in designing authentic and meaningful learning experiences when teaching research methods.
Editorial del número especial: Codiseño de situaciones educativas enriquecidas con TIC
Authors: Marín Victoria I. , Villagrá Sara L.
Published: December 2020

El diseño educativo, o más conocido por su denominación en inglés (learning design), es una línea de trabajo e investigación en el campo de la tecnología educativa con largo recorrido, que ha crecido en campo de acción e influencia con el tiempo, pudiéndose definir actualmente como “un proceso formal para planificar actividades educativas enriquecidas con tecnología, normalmente apoyado por una comunidad donde se pueden compartir y reutilizar diseños e ideas” (Lewin et al., p. 1132). A pesar de la larga trayectoria y amplitud del campo del diseño educativo, este número especial tiene como foco solo alguna de dichas líneas de trabajo. Concretamente nos centramos en este número especial en el codiseño educativo que, además, está vinculado, en muchas ocasiones, al desarrollo profesional docente para la integración de las TIC y a la importancia del diseño colaborativo del currículo, así como a la creación de comunidades de práctica de docentes que incluyen el codiseño. En este número especial nos planteamos, pues, proporcionar una visión amplia del diseño y, en especial, del codiseño educativo enriquecido con TIC, y responder desde la teoría y la práctica a la pregunta, ¿cuáles son las prácticas y teorías más efectivas en el campo del codiseño?