bluuebunny/crossref_metadata_2025 huggingface dataset:
Associations of Preconception Exposure to Air Pollution and Greenness with Offspring Asthma and Hay Fever
Authors: Kuiper Ingrid Nordeide , Markevych Iana , Accordini Simone , Bertelsen Randi J. , Bråbäck Lennart , Christensen Jesper Heile , Forsberg Bertil , Halvorsen Thomas , Heinrich Joachim , Hertel Ole , Hoek Gerard , Holm Mathias , de Hoogh Kees , Janson Christer , Malinovschi Andrei , Marcon Alessandro , Sigsgaard Torben , Svanes Cecilie , Johannessen Ane
Published: August 2020

We investigated if greenness and air pollution exposure in parents’ childhood affect offspring asthma and hay fever, and if effects were mediated through parental asthma, pregnancy greenness/pollution exposure, and offspring exposure. We analysed 1106 parents with 1949 offspring (mean age 35 and 6) from the Respiratory Health in Northern Europe, Spain and Australia (RHINESSA) generation study. Mean particulate matter (PM2.5 and PM10), nitrogen dioxide (NO2), black carbon (BC), ozone (O3) (µg/m3) and greenness (normalized difference vegetation index (NDVI)) were calculated for parents 0–18 years old and offspring 0–10 years old, and were categorised in tertiles. We performed logistic regression and mediation analyses for two-pollutant models (clustered by family and centre, stratified by parental lines, and adjusted for grandparental asthma and education). Maternal medium PM2.5 and PM10 exposure was associated with higher offspring asthma risk (odds ratio (OR) 2.23, 95%CI 1.32–3.78, OR 2.27, 95%CI 1.36–3.80), and paternal high BC exposure with lower asthma risk (OR 0.31, 95%CI 0.11–0.87). Hay fever risk increased for offspring of fathers with medium O3 exposure (OR 4.15, 95%CI 1.28–13.50) and mothers with high PM10 exposure (OR 2.66, 95%CI 1.19–5.91). The effect of maternal PM10 exposure on offspring asthma was direct, while for hay fever, it was mediated through exposures in pregnancy and offspring’s own exposures. Paternal O3 exposure had a direct effect on offspring hay fever. To conclude, parental exposure to air pollution appears to influence the risk of asthma and allergies in future offspring.
Steps Towards Comprehensive Heat Communication in the Frame of a Heat Health Warning System in Slovenia
Authors: Pogačar Tjaša , Žnidaršič Zala , Kajfež Bogataj Lučka , Črepinšek Zalika
Published: August 2020

Occupational heat stress has an important negative impact on the well-being, health and productivity of workers and should; therefore, be recognized as a public health issue in Europe. There is no comprehensive heat health warning system in Slovenia combining public health measures with meteorological forecasts. The aim of this research was to provide insight into the development of such a system in Slovenia, turning the communication from the current meteoalarm into a broader system that has more information for different social groups. To achieve this goal, the following steps were used: Analysis of summer temperatures and issued meteoalarms, a survey of the general knowledge about heat among the public, organization and management of two stakeholder symposia, and a final survey on workers’ opinions on heat stress and measures, supplemented by interviews with employers. Summer average daily temperature distributions in Slovenia changed during the investigated period (1961–2019) and the mean values increased over time by 2–3 °C. Additionally, the number of days with fulfilled yellow (potentially dangerous) and especially orange (dangerous) meteoalarm conditions increased significantly after 1990. The survey of the general public about heat stress and warnings showed that efforts to raise awareness of heat issues need to be intensified and that public health measures should effectively target vulnerable groups. Stakeholder symposia and further surveys have shown that awareness and understanding of the negative effects of heat stress on health and productivity are still quite low, so effective ways of disseminating information to different sectors while striking the best balance between efficiency, feasibility and economic cost have to be found.
Path Optimization of Medical Waste Transport Routes in the Emergent Public Health Event of COVID-19: A Hybrid Optimization Algorithm Based on the Immune–Ant Colony Algorithm
Authors: Liu Ziyuan , Li Zhi , Chen Weiming , Zhao Yunpu , Yue Hanxun , Wu Zhenzhen
Published: August 2020

In response to the emergent public health event of COVID-19, the efficiency of transport of medical waste from hospitals to disposal stations is a worthwhile issue to study. In this paper, based on the actual situation of COVID-19 and environmental impact assessment guidelines, an immune algorithm is used to establish a location model of urban medical waste storage sites. In view of the selection of temporary storage stations and realistic transportation demand, an efficiency-of-transport model of medical waste between hospitals and temporary storage stations is established by using an ant colony–tabu hybrid algorithm. In order to specify such status, Wuhan city in Hubei Province, China—considered the first city to suffer from COVID-19—was chosen as an example of verification; the two-level model and the immune algorithm–ant colony optimization–tabu search (IA–ACO–TS) algorithm were used for simulation and testing, which achieved good verification. To a certain extent, the model and the algorithm are proposed to solve the problem of medical waste disposal, based on transit temporary storage stations, which we are convinced will have far-reaching significance for China and other countries to dispatch medical waste in response to such public health emergencies.
Job Satisfaction and Hospital Performance Rated by Physicians in China: A Moderated Mediation Analysis on the Role of Income and Person–Organization Fit
Authors: Chen Xiao , Liu Min , Liu Chaojie , Ruan Fang , Yuan Yan , Xiong Change
Published: August 2020

This study tested the effect of person–organization fit (P-O fit) in mediating the link between job satisfaction and hospital performance with income as a moderator. A questionnaire survey was conducted on 301 physicians from two public hospitals in Zhejiang province of China. Respondents were asked to rate their job satisfaction, value congruence (P-O fit) with the hospital, and the hospital’s performance. The mediating effect of P-O fit on the link between job satisfaction and hospital performance was tested through partial least squares-structural equation modeling (PLS-SEM). Income was introduced to the model as a moderator on the “P-O fit → hospital performance” and “job satisfaction → hospital performance” path, respectively. Higher job satisfaction and P-O fit were associated with higher ratings on hospital performance (p < 0.01). P-O fit had a partial mediating effect on the association between job satisfaction and hospital performance, accounting for 73% of the total effect. The effects of P-O fit and job satisfaction on hospital performance were stronger in the respondents with higher income. Overall, high job satisfaction is associated with high ratings on hospital performance, which is partially mediated through P-O fit. Value congruence is particularly important when financial tools are used to incentivize hospital physicians.
The Relationship between the COVID-19 Pandemic and Nursing Students’ Sense of Belonging: The Experiences and Nursing Education Management of Pre-Service Nursing Professionals
Authors: Santos Luis Miguel Dos
Published: August 2020

The COVID-19 pandemic has changed the orders and structures of societies, particularly in the fields of medical and nursing professions. The researcher aims to understand the experiences, sense of belonging, and decision-making processes about Japanese pre-service nursing students and how the COVID-19 pandemic, social distancing, and lockdown has influenced their understanding as pre-service nursing professionals in Japan. As this study focuses on the issues of pre-service nursing students, the researcher invited forty-nine pre-service nursing students for a virtual interview due to the recommendation of social distancing. To increase the coverage of the population, the researcher employed snowball sampling to recruit participants from all over Japan. Although the COVID-19 pandemic influenced the overall performance of the medical and nursing professions, all participants showed a sense of belonging as Japanese citizens and nursing professionals due to the natural disaster of their country. More importantly, all expressed their desires and missions to upgrade and improve the overall performance of the public health system due to the influence of the COVID-19 pandemic. The results discovered that many Japanese nursing students advocated that Japan’s national development, the benefits and advantages of their country, were of a greater importance than their own personal development and goals.
The Remedial Potential of Lycopene in Pancreatitis through Regulation of Autophagy
Authors: Choi Suyun , Kim Hyeyoung
Published: August 2020

Autophagy is an evolutionarily conserved process that degrades damaged organelles and recycles macromolecules to support cell survival. However, in certain disease states, dysregulated autophagy can play an important role in cell death. In pancreatitis, the accumulation of autophagic vacuoles and damaged mitochondria and premature activation of trypsinogen are shown in pancreatic acinar cells (PACs), which are the hallmarks of impaired autophagy. Oxidative stress mediates inflammatory signaling and cytokine expression in PACs, and it also causes mitochondrial dysfunction and dysregulated autophagy. Thus, oxidative stress may be a mediator for autophagic impairment in pancreatitis. Lycopene is a natural pigment that contributes to the red color of fruits and vegetables. Due to its antioxidant activity, it inhibited oxidative stress-induced expression of cytokines in experimental models of acute pancreatitis. Lycopene reduces cell death through the activation of 5′-AMP-activated protein kinase-dependent autophagy in certain cells. Therefore, lycopene may ameliorate pancreatitis by preventing oxidative stress-induced impairment of autophagy and/or by directly activating autophagy in PACs.
The Mitochondrial Dysfunction Hypothesis in Autism Spectrum Disorders: Current Status and Future Perspectives
Authors: Citrigno Luigi , Muglia Maria , Qualtieri Antonio , Spadafora Patrizia , Cavalcanti Francesca , Pioggia Giovanni , Cerasa Antonio
Published: August 2020

Autism spectrum disorders (ASDs) constitute a set of heterogeneous neurodevelopmental conditions, characterized by a wide genetic variability that has led to hypothesize a polygenic origin. The metabolic profiles of patients with ASD suggest a possible implication of mitochondrial pathways. Although different physiological and biochemical studies reported deficits in mitochondrial oxidative phosphorylation in subjects with ASD, the role of mitochondrial DNA variations has remained relatively unexplored. In this review, we report and discuss very recent evidence to demonstrate the key role of mitochondrial disorders in the development of ASD.
Microbiota-Derived Metabolites in Tumor Progression and Metastasis
Authors: Rossi Tania , Vergara Daniele , Fanini Francesca , Maffia Michele , Bravaccini Sara , Pirini Francesca
Published: August 2020

Microbial communities and human cells, through a dynamic crosstalk, maintain a mutualistic relationship that contributes to the maintenance of cellular metabolism and of the immune and neuronal systems. This dialogue normally occurs through the production and regulation of hormonal intermediates, metabolites, secondary metabolites, proteins, and toxins. When the balance between host and microbiota is compromised, the dynamics of this relationship change, creating favorable conditions for the development of diseases, including cancers. Microbiome metabolites can be important modulators of the tumor microenvironment contributing to regulate inflammation, proliferation, and cell death, in either a positive or negative way. Recent studies also highlight the involvement of microbiota metabolites in inducing epithelial–mesenchymal transition, thus favoring the setup of the metastatic niche. An investigation of microbe-derived metabolites in “liquid” human samples, such as plasma, serum, and urine, provide further information to clarify the relationship between host and microbiota.
Targeting Hypoxia Sensitizes TNBC to Cisplatin and Promotes Inhibition of Both Bulk and Cancer Stem Cells
Authors: Sulaiman Andrew , McGarry Sarah , Chambers Jason , Al-Kadi Emil , Phan Alexandra , Li Li , Mediratta Karan , Dimitroulakos Jim , Addison Christina , Li Xuguang , Wang Lisheng
Published: August 2020

Development of targeted therapies for triple-negative breast cancer (TNBC) is an unmet medical need. Cisplatin has demonstrated its promising potential for the treatment of TNBC in clinical trials; however, cisplatin treatment is associated with hypoxia that, in turn, promotes cancer stem cell (CSC) enrichment and drug resistance. Therapeutic approaches to attenuate this may lead to increased cisplatin efficacy in the clinic for the treatment of TNBC. In this report we analyzed clinical datasets of TNBC and found that TNBC patients possessed higher levels of EGFR and hypoxia gene expression. A similar expression pattern was also observed in cisplatin-resistant ovarian cancer cells. We, thus, developed a new therapeutic approach to inhibit EGFR and hypoxia by combination treatment with metformin and gefitinib that sensitized TNBC cells to cisplatin and led to the inhibition of both CD44+/CD24− and ALDH+ CSCs. We demonstrated a similar inhibition efficacy on organotypic cultures of TNBC patient samples ex vivo. Since these drugs have already been used frequently in the clinic; this study illustrates a novel, clinically translatable therapeutic approach to treat patients with TNBC.
Same-Day Versus Non-Simultaneous Extracorporeal Membrane Oxygenation Support for In-Hospital Cardiac Arrest Complicating Acute Myocardial Infarction
Authors: Vallabhajosyula Saraschandra , Patlolla Sri Harsha , Bell Malcolm R. , Cheungpasitporn Wisit , Stulak John M. , Schears Gregory J. , Barsness Gregory W. , Holmes David R.
Published: August 2020

Background: Although extracorporeal membrane oxygenation (ECMO) is used for hemodynamic support for in-hospital cardiac arrest (IHCA) complicating acute myocardial infarction (AMI), there are limited data on the outcomes stratified by the timing of initiation of this strategy. Methods: Adult (>18 years) AMI admissions with IHCA were identified using the National Inpatient Sample (2000–2017) and the timing of ECMO with relation to IHCA was identified. Same-day vs. non-simultaneous ECMO support for IHCA were compared. Outcomes of interest included in-hospital mortality, temporal trends, hospitalization costs, and length of stay. Results: Of the 11.6 million AMI admissions, IHCA was noted in 1.5% with 914 (<0.01%) receiving ECMO support. The cohort receiving same-day ECMO (N = 795) was on average female, with lower comorbidity, higher rates of ST-segment-elevation AMI, shockable rhythm, and higher rates of complications. Compared to non-simultaneous ECMO, the same-day ECMO cohort had higher rates of coronary angiography (67.5% vs. 51.3%; p = 0.001) and comparable rates of percutaneous coronary intervention (58.9% vs. 63.9%; p = 0.32). The same-day ECMO cohort had higher in-hospital mortality (63.1% vs. 44.5%; adjusted odds ratio 3.98 (95% confidence interval 2.34–6.77); p < 0.001), shorter length of stay, and lower hospitalization costs. Older age, minority race, non-ST-segment elevation AMI, multiorgan failure, and complications independently predicted higher in-hospital mortality in IHCA complicating AMI. Conclusions: Same-day ECMO support for IHCA was associated with higher in-hospital mortality compared to those receiving non-simultaneous ECMO support. Though ECMO-assisted CPR is being increasingly used, careful candidate selection is key to improving outcomes in this population.
Epigenetic Regulation by Non-Coding RNAs in the Avian Immune System
Authors: Chen Xiaolan , Ali Abdalla Bahareldin , Li Zhenhui , Nie Qinghua
Published: August 2020

The identified non-coding RNAs (ncRNAs) include circular RNAs, long non-coding RNAs, microRNAs, ribosomal RNAs, small interfering RNAs, small nuclear RNAs, piwi-interacting RNAs, and transfer RNAs, etc. Among them, long non-coding RNAs, circular RNAs, and microRNAs are regulatory RNAs that have different functional mechanisms and were extensively participated in various biological processes. Numerous research studies have found that circular RNAs, long non-coding RNAs, and microRNAs played their important roles in avian immune system during the infection of parasites, virus, or bacterium. Here, we specifically review and expand this knowledge with current advances of circular RNAs, long non-coding RNAs, and microRNAs in the regulation of different avian diseases and discuss their functional mechanisms in response to avian diseases.
An Overview on the Catalytic Materials Proposed for the Simultaneous Removal of NOx and Soot
Authors: Castoldi Lidia
Published: August 2020

Vehicular pollution has become a major problem in urban areas due to the exponential increase in the number of automobiles. Typical exhaust emissions, which include nitrogen oxides (NOx), hydrocarbons (HC), carbon monoxide (CO), soot, and particulate matter (PM), doubtless have important negative effects on the environment and human health, including cardiovascular effects such as cardiac arrhythmias and heart attacks, and respiratory effects such as asthma attacks and bronchitis. The mitigation measures comprise either the use of clean alternative fuels or the use of innovative technologies. Several existing emission control technologies have proven effective at controlling emissions individually, such as selective catalytic reduction (SCR) and lean NOx trap (LNT) to reduce NOx and diesel particulate filter (DPF) specifically for PM abatement. These after-treatment devices are the most profitable means to reduce exhaust emissions to acceptable limits (EURO VI norms) with very little or no impact on the engine performances. Additionally, the relative lack of physical space in which to install emissions-control equipment is a key challenge for cars, especially those of small size. For this reason, to reduce both volume and cost of the after-treatment devices integrated catalytic systems (e.g., a sort of a “single brick”) have been proposed, reducing both NOx and PM simultaneously. This review will summarize the currently reported materials for the simultaneous removal of NOx and soot, with particular attention to their nature, properties, and performances.
Decision Support System in the Field of Defects Assessment in the Metal Matrix Composites Castings
Authors: Sika Robert , Rogalewicz Michał , Popielarski Paweł , Czarnecka-Komorowska Dorota , Przestacki Damian , Gawdzińska Katarzyna , Szymański Paweł
Published: August 2020

This paper presented a new approach to decision making support of defects assessment in metal matrix composites (MMC). It is a continuation of the authors’ papers in terms of a uniform method of casting defects assessment. The idea of this paper was to design an open-access application (follow-up system called Open Atlas of Casting Defects (OACD)) in the area of industry and science. This a new solution makes it possible to quickly identify defect types considering the new classification of casting defects. This classification complements a classical approach by adding a casting defect group called structure defects, which is especially important for metal matrix composites. In the paper, an application structure, and the possibility of its use in casting defects assessment were introduced.
Characteristics of 10-Methacryloyloxidecyl Dihydrogen Phosphate Monomer in Self-Etching Two-Bottled Dental Adhesive System: Comparison with Commercial Products
Authors: Roh Jiyeon , Shin Hyunjung , Hong Min-Ho
Published: August 2020

Dentin bonding is a key in restorative dentistry. Here, we developed a self-etching two-bottle adhesive system containing 10-methacryloyloxidecyl dihydrogen phosphate monomer (MDP) and the physical, mechanical, and biocompatible properties were evaluated. The characteristics of MDP were analyzed using nuclear magnetic resonance (NMR). Tests for water sorption and solubility, the shear-bond strengths to dentin and enamel, and cytotoxicity were performed. The newly-blended experimental group showed the lowest thickness and water sorption and solubility values. The shear bond strength of enamel and dentin were comparable to control groups (the three other products were ClearfilTM, UniFil®, and AdheSE®). All test groups showed 60% of cell viability. In this study, the properties of the newly-synthesized adhesive are comparable with the others. The fundamental goal of this study is to get the MDP patent released, as it is intended for domestic production. For this purpose, this dentin adhesive was developed and compared with the commercial product.
Numerical Simulation and Experimental Confirmation of a Bimetallic Pipe Forming Process
Authors: Dong Zhiqiang , Xu Zhenzhen , Wang Wenke , Bi Zongyue , Zhang Jianxun
Published: August 2020

Most oil and gas is transported by pipeline, and corrosion causes a great threat to the service life of the pipeline; bimetallic pipe, which combines the advantages of good mechanical properties, good corrosion resistance, and relatively low price, is a good choice for high-pressure and corrosion-resistant pipe, but its manufacturing process and stress distribution are more complex than single metal pipe. JCO is a widely used cold forming method for pipes which is named by the shape of the plate in the forming process, i.e. J-shape, C-shape and O-shape, and the forming process is an important parameter that determines the level of imperfections and residual stresses in a pipe, and residual tensile stress will accelerate corrosion failure of the pipe. In this study, the three-dimensional (3D) finite element method (FEM) is used to simulate the pre-bending and JCO forming process of a 2205/X65 bimetallic pipe. The model and the simulated results are validated by digital image correlation (DIC) experimental and the opening width of the formed pipe billet, respectively. The influence factors of the stresses are studied. Further, a two-dimensional (2D) model is established to study the characteristics of bimetallic plate bending and the stress distribution at the interface of different materials, and the results are compared with that of three-dimensional model.
A Review on Metallic Alloys Fabrication Using Elemental Powder Blends by Laser Powder Directed Energy Deposition Process
Authors: Chen Yitao , Zhang Xinchang , Parvez Mohammad Masud , Liou Frank
Published: August 2020

The laser powder directed energy deposition process is a metal additive manufacturing technique, which can fabricate metal parts with high geometric and material flexibility. The unique feature of in-situ powder feeding makes it possible to customize the elemental composition using elemental powder mixture during the fabrication process. Thus, it can be potentially applied to synthesize industrial alloys with low cost, modify alloys with different powder mixtures, and design novel alloys with location-dependent properties using elemental powder blends as feedstocks. This paper provides an overview of using a laser powder directed energy deposition method to fabricate various types of alloys by feeding elemental powder blends. At first, the advantage of laser powder directed energy deposition in manufacturing metal alloys is described in detail. Then, the state-of-the-art research and development in alloys fabricated by laser powder directed energy deposition through a mix of elemental powders in multiple categories is reviewed. Finally, critical technical challenges, mainly in composition control are discussed for future development.
Immunomodulatory Effects of N-Acetyl Chitooligosaccharides on RAW264.7 Macrophages
Authors: Deng Jun-Jin , Li Zong-Qiu , Mo Ze-Quan , Xu Shun , Mao He-Hua , Shi Dan , Li Zhi-Wei , Dan Xue-Ming , Luo Xiao-Chun
Published: August 2020

The ongoing development of new production methods may lead to the commercialization of N-acetyl chitooligosaccharides (NACOS), such as chitosan oligosaccharides (COS). The bioactivity of NACOS, although not well detailed, differs from that of COS, as they have more acetyl groups than COS. We used two enzymatically produced NACOS with different molecular compositions and six NACOS (NACOS1–6) with a single degree of polymerization to verify their immunomodulatory effects on the RAW264.7 macrophage cell line. We aimed to identify any differences between COS and various NACOS with a single degree of polymerization. The results showed that NACOS had similar immune enhancement effects on RAW264.7 cells as COS, including the generation of reactive oxygen species (ROS), phagocytotic activity, and the production of pro-inflammation cytokines (IL-1β, IL-6, and TNF-α). However, unlike COS and lipopolysaccharide (LPS), NACOS1 and NACOS6 significantly inhibited nitric oxide (NO) production. Besides their immune enhancement effects, NACOS also significantly inhibited the LPS-induced RAW264.7 inflammatory response with some differences between various polymerization degrees. We confirmed that the NF-κB pathway is associated with the immunomodulatory effects of NACOS on RAW264.7 cells. This study could inform the application of NACOS with varying different degrees of polymerization in human health.
The Value of Targeting Complement Components in Asthma
Authors: Mohamed Marwa M. E. , Nicklin Alicia D. , Stover Cordula M.
Published: August 2020

Asthma is an important respiratory illness. Though pharmacological and biological treatment is well established and is staged according to endotypes and their responses to treatment, novel avenues are being explored. Our focus is complement. In this viewpoint, we evaluate the approach to target complement in this complex hypersensitivity reaction that develops chronicity and has a personal—as well as a societal—cost.
Combined Ammonia and Electron Processing of a Carbon-Rich Ruthenium Nanomaterial Fabricated by Electron-Induced Deposition
Authors: Rohdenburg Markus , Fröch Johannes E. , Martinović Petra , Lobo Charlene J. , Swiderek Petra
Published: August 2020

Ammonia (NH3)-assisted purification of deposits fabricated by focused electron beam-induced deposition (FEBID) has recently been proven successful for the removal of halide contaminations. Herein, we demonstrate the impact of combined NH3 and electron processing on FEBID deposits containing hydrocarbon contaminations that stem from anionic cyclopentadienyl-type ligands. For this purpose, we performed FEBID using bis(ethylcyclopentadienyl)ruthenium(II) as the precursor and subjected the resulting deposits to NH3 and electron processing, both in an environmental scanning electron microscope (ESEM) and in a surface science study under ultrahigh vacuum (UHV) conditions. The results provide evidence that nitrogen from NH3 is incorporated into the carbon content of the deposits which results in a covalent nitride material. This approach opens a perspective to combine the promising properties of carbon nitrides with respect to photocatalysis or nanosensing with the unique 3D nanoprinting capabilities of FEBID, enabling access to a novel class of tailored nanodevices.
Predicting the Logarithmic Distribution Factors for Coprecipitation into an Organic Salt: Selection of Rare Earths into a Mixed Oxalate
Authors: Watts Harry , Leong Yee-Kwong
Published: August 2020

Thermodynamic modelling of a leaching system that involves concurrent precipitation depends on an understanding of how the metals distribute into the precipitate before an assessment of solubility can be made. It has been suggested in the past that a pair of rare earths (A and B) in solution will separate from each other by oxalate precipitation according to a logarithmic distribution coefficient (λ), determined by the kinetics of the precipitation. By contrast, the present study hypothesises that λ may be approximated from thermodynamic terms, including the solubility product (KSp) of each rare earth oxalate and the stability constant (β1) for the mono-oxalato complex of each rare earth. The proposed model was used to calculate λ between pairs of rare earths. An experimental study was conducted to determine λ between selected pairs using homogenous precipitation through the hydrolysis of an oxalic acid ester, with fairly close agreement to the values under the proposed model. Though this model requires more thorough testing, as well as application to other organic salts, it may provide insight into distribution factors of a precipitate formed by a sequence of organic complexes.
Simultaneous Analysis of Hydroquinone, Arbutin, and Ascorbyl Glucoside Using a Nanocomposite of Ag@AgCl Nanoparticles, Ag2S Nanoparticles, Multiwall Carbon Nanotubes, and Chitosan
Authors: Butwong Nutthaya , Kunawong Thidarat , Luong John H. T.
Published: August 2020

A nanocomposite comprising Ag nanoparticles on AgCl/Ag2S nanoparticles was decorated on multi-walled carbon nanotubes and used to modify a glassy carbon electrode. Chitosan was also formulated in the nanocomposite to stabilize Ag2S nanoparticles and interact strongly with the glucose moiety of arbutin (AR) and ascorbyl glucoside (AA2G), two important ingredients in whitening lotion products. The modified electrode was characterized by Fourier transform infrared spectroscopy (FTIR), transmission electron microscopy (TEM), and scanning electron microscopy (SEM) and cyclic voltammetry and used for the simultaneous analysis of hydroquinone (HQ), AR, and AA2G. The electrode showed excellent electrocatalysis towards the analytes by shifting the anodic peak potential to a negative direction with ≈5-fold higher current. The sensor displayed a linearity of 0.91–27.2 μM for HQ, 0.73–14.7 μM for AR, and 1.18–11.8 μM for AA2G, without cross-interference. A detection limit was 0.4 μM for HQ, 0.1 μM for AR, and 0.25 μM for AA2G. The sensor was applied to determine HQ, AR, and AA2G spiked in the whitening lotion sample with excellent recovery. The measured concentration of each analyte was comparable to that of the high performance liquid chromatographic (HPLC) method.
Photo-Induced Black Phase Stabilization of CsPbI3 QDs Films
Authors: Erazo Eider A. , Sánchez-Godoy H.E. , Gualdrón-Reyes Andrés F. , Masi Sofia , Mora-Seró Iván
Published: August 2020

α-CsPbI3 quantum dots (QDs) show outstanding photoelectrical properties that had been harnessed in the fabrication of perovskite QDs solar cells. Nevertheless, the stabilization of the CsPbI3 perovskite cubic phase remains a challenge due to its own thermodynamic and the presence of surface defects. Herein, we report the optimization of the CsPbI3 QDs solar cells, by monitoring the structure, the morphology and the optoelectronic properties after a precise treatment, consisting of the conventional solvent washing with a time limited ultraviolet (UV) exposure combination, during the layer-by-layer deposition. The UV treatment compensates the defects coming from the essential but deleterious washing treatment. The material is stable for 200 h and the PCE improved by the 25% compared with that of the device without UV treatment. The photo-enhanced ion mobility mechanism is discussed as the main process for the CsPbI3 QDs and solar cell stability.
Dietary Acrylamide Intake and Risk of Lung Cancer: The Japan Public Health Center Based Prospective Study
Authors: Liu Rong , Zha Ling , Sobue Tomotaka , Kitamura Tetsuhisa , Ishihara Junko , Kotemori Ayaka , Ikeda Sayaka , Sawada Norie , Iwasaki Motoki , Tsugane Shoichiro
Published: August 2020

Acrylamide, which forms in heat-treated foods with high carbohydrate content, is a probable human carcinogen. This study aimed to evaluate the association between dietary acrylamide intake and lung cancer using data from the Japan Public Health Center based Prospective Study. Our study included 85,303 participants who completed a food frequency questionnaire. Cox proportional hazards regression models were used to assess hazard ratios and 95% confidence intervals (CIs) after adjusting for confounders. After 14.3 years and 15.4 years of mean follow-up period, 1187 and 485 lung cancer cases were identified in men and women, respectively. The multivariable-adjusted hazard ratios of 10-µg/day increment in acrylamide intake were 1.01 (95% CI, 0.99–1.02) in men and 0.98 (95% CI, 0.95–1.02) in women. Compared with the lowest quartile of acrylamide intake, the hazard ratios for the highest quartile were 1.13 (95% CI, 0.95–1.33; p for trend = 0.12) in men and 1.03 (95% CI, 0.78–1.36; p for trend = 0.86) in women in the multivariable-adjusted model. Moreover, there was also no significant association observed in the stratified analysis for histological subtypes of lung cancer. This study demonstrated that dietary acrylamide intake was not associated with increased lung cancer risk in the Japanese population.
Effects of Protein Supplementation Combined with Exercise Training on Muscle Mass and Function in Older Adults with Lower-Extremity Osteoarthritis: A Systematic Review and Meta-Analysis of Randomized Trials
Authors: Liao Chun-De , Wu Yen-Tzu , Tsauo Jau-Yih , Chen Pey-Rong , Tu Yu-Kang , Chen Hung-Chou , Liou Tsan-Hon
Published: August 2020

Aging and osteoarthritis (OA) are associated with a high risk of muscle mass loss, which can lead to physical disability. This study investigated the effectiveness of protein supplementation combined with exercise training (PS + ET) in improving muscle mass and functional outcomes in older adults with lower-limb OA. A comprehensive search of online databases was performed to identify randomized controlled trials (RCTs) on the effectiveness of PS + ET in older adults with hip or knee OA. Meta-analysis and risk of bias assessment of the included RCTs were conducted. Six RCTs were included in this systemic review; they had a median (range/total) Physiotherapy Evidence Database (PEDro) score of 7 (6–9) out of 10, respectively. Five RCTs that enrolled patients who underwent total joint replacement were included in this meta-analysis. The PS + ET group exhibited significant improvements in muscle mass (standard mean difference [SMD] = 1.13, p < 0.00001), pain (SMD = 1.36, p < 0.00001), and muscle strength (SMD = 0.44, p = 0.04). Our findings suggest that PS + ET improves muscle mass, muscle strength, and functional outcomes and reduces pain in older adults with lower-limb OA, particularly in those who have undergone total joint replacement.
Conservation of Wild Food Plants and Their Potential for Combatting Food Insecurity in Kenya as Exemplified by the Drylands of Kitui County
Authors: Mutie Fredrick Munyao , Rono Peninah Cheptoo , Kathambi Vivian , Hu Guang-Wan , Wang Qing-Feng
Published: August 2020

Wild food plants are important resources for people living in dry areas of Kenya. A botanical inventory of vascular plants of Kitui county was compiled from specimens collected during field investigations in Kitui county, at the East African (EA) herbarium and from literature reporting on plants of Kitui county. To obtain an inventory of wild edible plants found in Kitui county, literature reporting on wild edible plants of Kenya were searched and combined with the use reports obtained from field surveys in Kitui county. A total of 199 wild plants found in Kitui county have the potential of being utilized as foods in different ways. Plant species growing either as trees or shrubs (83 species) and herbs (36 species) are the dominant life forms while the best represented plant families are Leguminosae (25 species) and Malvaceae (17 species). Fruits (124 reports) and leaves (56 reports) are the common plant parts collected for food. Fruits (120 species) and vegetables (44 species) are the common wild food types in Kitui county. Further studies on species distribution are necessary to address conservation concerns that may threaten such plants.
Electromagnetic Interference Shield of Highly Thermal-Conducting, Light-Weight, and Flexible Electrospun Nylon 66 Nanofiber-Silver Multi-Layer Film
Authors: Kim Jaeyeon , Lee Suyeong , Kim Changho , Park Yeongcheol , Kim Mi-Hyun , Seol Jae Hun
Published: August 2020

A light-weight, flexible electromagnetic interference (EMI) shield was prepared by creating a layer-structured metal-polymer composite film consisting of electrospun nylon 66 nanofibers with silver films. The EMI shielding effectiveness (SE), specific SE, and absolute SE of the composite were as high as 60.6 dB, 67.9 dB cm3/g, and 6792 dB cm2/g in the X- and Ku-bands, respectively. Numerical and analytical calculations suggest that the energy of EM waves is predominantly absorbed by inter-layer multiple reflections. Because the absorbed EM energy is dissipated as heat, the thermal conductivity of absorption-dominant EMI shields is highly significant. Measured thermal conductivity of the composite was found to be 4.17 Wm−1K−1 at room temperature, which is higher than that of bulk nylon 66 by a factor of 16.7. The morphology and crystallinity of the composite were examined using scanning electron microscopy and differential scanning calorimetry, respectively. The enhancement of thermal conductivity was attributed to an increase in crystallinity of the nanofibers, which occurred during the electrospinning and subsequent hot pressing, and to the high thermal conductivity of the deposited silver films. The contribution of each fabrication process to the increase in thermal conductivity was investigated by measuring the thermal conductivity values after each fabrication process.
Synthesis of Amphiphilic Statistical Copolymers Bearing Methoxyethyl and Phosphorylcholine Groups and Their Self-Association Behavior in Water
Authors: Nguyen Thi Lien , Kawata Yuuki , Ishihara Kazuhiko , Yusa Shin-ichi
Published: August 2020

Biocompatible amphiphilic statistical copolymers P(MEA/MPCm) composed of 2-methoxyethyl acrylate (MEA) and 2-methacryloyloxyethyl phosphorylcholine (MPC) were prepared with three different mol% of the hydrophilic unit MPC (m = 6, 12 and 46 mol%). The monomer reactivity ratios of MEA (rMEA) and MPC (rMPC) were 0.53 and 2.21, respectively. The rMEA × rMPC value of 1.17 demonstrated that statistical copolymerization was successful. P(MEA/MPC12) and P(MEA/MPC46) copolymers did not undergo aggregation in water, whereas the P(MEA/MPC6) copolymer formed micelles in water with a hydrodynamic radius (Rh) of 96.9 nm and a critical aggregation concentration, which was determined using pyrene fluorescence, at 0.0082 g/L. The restricted motion of the protons in the hydrophobic MEA units in the micelles’ cores provided additional evidence of self-association in P(MEA/MPC6).
Quality Assessment of PROBA-V Surface Albedo V1 for the Continuity of the Copernicus Climate Change Service
Authors: Sánchez-Zapero Jorge , Camacho Fernando , Martínez-Sánchez Enrique , Lacaze Roselyne , Carrer Dominique , Pinault Florian , Benhadj Iskander , Muñoz-Sabater Joaquín
Published: August 2020

The Copernicus Climate Change Service (C3S) includes estimates of Essential Climate Variables (ECVs) as a series of Climate Data Records (CDRs) derived from satellite data. The C3S Surface Albedo (SA) v1.0 CDR is composed of observations from National Oceanic and Atmospheric Administration (NOAA) Very High Resolution Radiometers (AVHRR) (1981–2005), and VEGETATION sensors onboard Satellites for the Observation of the Earth (SPOT/VGT) (1998–2014) and Project for Onboard Autonomy satellite (PROBA-V) (2014–2020), and will continue with Sentinel-3 (from 2020 onwards). The goal of this study is to assess the uncertainties associated with the C3S PROBA-V SA v1.0 product, with a focus on the transition from SPOT/VGT to PROBA-V. The methodology followed the good practices recommended by the Land Product Validation sub-group (LPV) of the Working Group on Calibration and Validation (WGCV) of the Committee on Earth Observing Satellites (CEOS) for the validation of satellite-derived global albedo products. Several performance criteria were evaluated, including an intercomparison with National Aeronautics and Space Agency (NASA) MCD43A3 C6 products. C3S PROBA-V SA v1.0 and MCD43A3 C6 showed similar completeness but had higher fractions of missing data than C3S SPOT/VGT SA v1.0. C3S PROBA-V SA v1.0 showed similar precision (~1%) to MCD43A3 C6, improving the results of SPOT/VGT SA v1.0 (2–3%), but C3S PROBA-V SA v1.0 provided residual noise in the near-infrared (NIR). Good spatio-temporal continuity between C3S PROBA-V and SPOT/VGT SA v1.0 products was found with a mean bias between ±2%. The comparison with MCD43A3 C6 showed positive mean biases (5%, 8%, and 12% for visible, NIR and total shortwave, respectively). The accuracy assessment with ground measurements showed a median error of 18.4% with systematic overestimation (positive bias of 11.5%). The percentage of PROBA-V retrievals complying with the C3S target requirements was 28.6%.
Benchmark-Based Reference Model for Evaluating Botnet Detection Tools Driven by Traffic-Flow Analytics
Authors: Huancayo Ramos Katherinne Shirley , Sotelo Monge Marco Antonio , Maestre Vidal Jorge
Published: August 2020

Botnets are some of the most recurrent cyber-threats, which take advantage of the wide heterogeneity of endpoint devices at the Edge of the emerging communication environments for enabling the malicious enforcement of fraud and other adversarial tactics, including malware, data leaks or denial of service. There have been significant research advances in the development of accurate botnet detection methods underpinned on supervised analysis but assessing the accuracy and performance of such detection methods requires a clear evaluation model in the pursuit of enforcing proper defensive strategies. In order to contribute to the mitigation of botnets, this paper introduces a novel evaluation scheme grounded on supervised machine learning algorithms that enable the detection and discrimination of different botnets families on real operational environments. The proposal relies on observing, understanding and inferring the behavior of each botnet family based on network indicators measured at flow-level. The assumed evaluation methodology contemplates six phases that allow building a detection model against botnet-related malware distributed through the network, for which five supervised classifiers were instantiated were instantiated for further comparisons—Decision Tree, Random Forest, Naive Bayes Gaussian, Support Vector Machine and K-Neighbors. The experimental validation was performed on two public datasets of real botnet traffic—CIC-AWS-2018 and ISOT HTTP Botnet. Bearing the heterogeneity of the datasets, optimizing the analysis with the Grid Search algorithm led to improve the classification results of the instantiated algorithms. An exhaustive evaluation was carried out demonstrating the adequateness of our proposal which prompted that Random Forest and Decision Tree models are the most suitable for detecting different botnet specimens among the chosen algorithms. They exhibited higher precision rates whilst analyzing a large number of samples with less processing time. The variety of testing scenarios were deeply assessed and reported to set baseline results for future benchmark analysis targeted on flow-based behavioral patterns.
Computer Vision System for Welding Inspection of Liquefied Petroleum Gas Pressure Vessels Based on Combined Digital Image Processing and Deep Learning Techniques
Authors: Cruz Yarens J. , Rivas Marcelino , Quiza Ramón , Beruvides Gerardo , Haber Rodolfo E.
Published: August 2020

One of the most important operations during the manufacturing process of a pressure vessel is welding. The result of this operation has a great impact on the vessel integrity; thus, welding inspection procedures must detect defects that could lead to an accident. This paper introduces a computer vision system based on structured light for welding inspection of liquefied petroleum gas (LPG) pressure vessels by using combined digital image processing and deep learning techniques. The inspection procedure applied prior to the welding operation was based on a convolutional neural network (CNN), and it correctly detected the misalignment of the parts to be welded in 97.7% of the cases during the method testing. The post-welding inspection procedure was based on a laser triangulation method, and it estimated the weld bead height and width, with average relative errors of 2.7% and 3.4%, respectively, during the method testing. This post-welding inspection procedure allows us to detect geometrical nonconformities that compromise the weld bead integrity. By using this system, the quality index of the process was improved from 95.0% to 99.5% during practical validation in an industrial environment, demonstrating its robustness.
Why do We Know So Much and Yet So Little? A Scoping Review of Willingness to Pay for Human Excreta Derived Material in Agriculture
Authors: Gwara Simon , Wale Edilegnaw , Odindo Alfred , Buckley Chris
Published: August 2020

Challenges associated with rapid population growth, urbanization, and nutrient mining have seen increased global research and development towards ‘waste to wealth’ initiatives, circular economy models, and cradle-to-cradle waste management principles. Closing the nutrient loop through safe recovery and valorization of human excreta for agricultural use may provide a sustainable method of waste management and sanitation. Understanding the market demand is essential for developing viable waste management and sanitation provision business models. The pathways and processes for the safe recovery of nutrients from human excreta are well-documented. However, only anecdotal evidence is available on the willingness to pay for human excreta-derived material in agriculture. This review closes this gap by identifying and synthesizing published evidence on farmers’ willingness to pay for human excreta-derived material for agricultural use. The Scopus and Web of Science search engines were used to search for the literature. The search results were screened, and the data were extracted, charted, and synthesized using the DistillerSR web-based application. The findings show that understanding willingness to pay for human excreta-derived material is still a nascent and emerging research area. Gender, education, and experience are common factors that influence the farmers’ willingness to pay. The findings show that pelletization, fortification, labeling, packaging, and certification are essential attributes in product development. The wide-scale commercialization can be achieved through incorporation of context-specific socioeconomic, religious and cultural influences on the estimation of willingness to pay. Promoting flexible legislation procedures, harmonization of regional legislations, and creating incentives for sustainable waste recovery and reuse may also promote the commercialization of circular nutrient economy initiatives. More empirical studies are required to validate willingness to pay estimates, especially using the best practice for conducting choice experiments.