bluuebunny/crossref_metadata_2025 huggingface dataset:
Serum 14-3-3 ETA levels in ankylosing spondylitis with pure axial involvement: Could it be a potential biomarker to assess disease activity?
Authors: Atalar Ebru , Kor Ahmet , Fırat Oğuz Esra , Konak Hatice Ecem , Orhan Kevser , Maraş Yüksel , Erten Şükran , Erel Özcan
Published: June 2023

Aim: The 14-3-3η (eta) protein has been associated with the severity of the disease and joint destruction in patients with rheumatoid arthritis (RA). It has also been shown to be likely to be effective in inflammatory events. We aimed to investigate whether eta levels could be a potential biomarker in the diagnosis of ankylosing spondylitis (AS) and in the determination of disease activity in patients with AS.Methods: This study included 51 patients diagnosed with AS and 49 healthy controls aged 20-65 years. The routine hemogram, erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP) levels were measured and the neutrophil/lymphocyte ratio (NLR) was calculated in the patients. The serum eta levels were also measured in the patient and healthy control groups. The Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and the Ankylosing Spondylitis Disease Activity Score (ASDAS) were used to assess disease activity. Sacroiliac joint radiographs of the patients were evaluated and the sacroiliitis was graded.Results: There was no statistically significant correlation between the degree of sacroiliitis, disease activity indices, and eta levels. There was no statistically significant correlation between eta levels and hematological parameters except for CRP. There was a negative, weak, and statistically significant relationship between the patients’ eta levels and CRP (r=-0.277; p=0.049). We could not find any correlation between the degree of sacroiliitis, disease activity indexes, and serum eta levels in AS patients.Conclusion: Serum eta levels are not a good biomarker for detecting disease activity in patients with ankylosing spondylitis. The 14-3-3η protein may play a more active role in rheumatic diseases where peripheral joint involvement is prominent.
ISTORIJA RAZVOJA MAKROEKONOMSKOG MODELA FILIPSOVE KRIVE
Authors: Mirotić Tanja
Published: June 2023

Koncept Filipsove krive datira još iz 1958. godine, kada je A. W. Philips dokazao inverzan odnos između stope nezaposlenosti i stope promjene novčanih nadnica na primjeru Velike Britanije. Nakon toga se veliki broj istaknutih ekonomista, kao što su Solow, Samuelson, Friedman, Lipsey i drugi, bavio istraživanjem ovog fenomena, koji je i danas relevantna tema. Kao dokaz aktuelnosti ovog teorijskog koncepta jeste i činjenica da ne postoji udžbenik iz oblasti makroekonomije, pa ni monetarne ekonomije, a da u svoj sadržaj ne uključuje Filipsovu krivu. Tokom 60-tih i 70-tih godina XX vijeka Filipsova kriva je predstavljala popularan instrument ekonomske politike. Iako tokom perioda stagflacije i šokova agregatne ponude, inverzan odnos između stope inflacije i stope nezaposlenosti nije postojao, događaji tokom 80-tih i 90-tih godina kao i kriza 2008. godine, aktuelizovali su ponovna razmatranja ovog teorijskog koncepta. S obzirom na to da je pojavljivanje i nestajanje inverznog odnosa između stope inflacije i stope nezaposlenosti nemoguće predvidjeti, sprovode se konstantna empirijska istraživanja koja testiraju validnost Filipsove krive u savremenim privredama. Svrha ovog rada jeste upoznavanje sa razvojem i nastankom ideje o inverznom odnosu stope inflacije i stope nezaposlenosti koji je predstavljen kroz model Filipsove krive, kao i uticajem ekonomskih politika na modifikaciju odnosa između pomenutih makroekonomskih indikatora.
The Effect of Service Quality on Patient Loyalty evidence from Privat Hospitality
Authors: Asriani Nora
Published: June 2023

This study aims to investigate the effect of service quality on patient loyalty in private hospitals. The population in this study were all patients at Krakatau Medika Hospital. The samples used were outpatient and inpatient patients with purposive sampling as a data collection technique. the test results show that all dimensions of service quality affect patient loyalty.
Profitability and Stock Return: Does Capital Structure Mediating This Association?
Authors: Sanusi Fauji
Published: June 2023

This study investigates whether profitability contribute to increase stock returns. Further, current study also examines the mediating role of firm’s capital structure on the relationship. Using 14 companies with 126 firm-years observations from listed manufacturing industry from 2009-2017 and rely on path analysis, this study finds that profitability has a significant positive effect on stock returns, but it has no significant effect on DER. In addition, we also evidence that DER has no significant effect on stock return. Therefore, current study document the importance of profitability to create the best market performance without rely heavily on capital structure. The implication of this study is that it is essential for managers to create a sustainable profitability which has possibility to effect firm performance, as the performance may affect capital market perception through the stock price.
EFFICIENCY COOPERATIVE AND ITS POTENTIAL FOR ABSORBING LABOR IN INDONESIA
Authors: Trisniarti Noviami , Nur Sofyana Nanda , Azhari Azhari
Published: June 2023

The number of cooperatives in Indonesia reaches hundreds of thousands, but of the many cooperatives only 40% are active. The data also shows that employment in these business entities is less than 1% of the total workforce absorbed in various business sectors in Indonesia. The main objective of this study is to measure the efficiency of cooperatives in Indonesia and see the long-term relationship between cooperative productivity and employment in Indonesia. This research is quantitative by using two data analysis tools of envelopment analysis (DEA and cointegration test. Data envelopment analysis is to measure the efficiency of cooperatives. Meanwhile, to look at employment absorption using cointegration test. This research uses three inputs, namely, own capital, external capital, and the number of managers and one output is the profit of the cooperative.As for the cointegration test, the variable used is cooperative efficiency with the number of workers in the cooperative sector in Indonesia.The data used are primary and secondary data.Primary data are data obtained from the field and secondary data from the ministry of cooperatives and small and medium enterprises of the Republic of Indonesia.The results of this research show that the level of efficiency of cooperatives in Indonesia is not yet efficient, however there is a long-term relationship between cooperatives and employment in Indonesia.
ARABICA COFFEE PROCESSED PRODUCT DEVELOPMENT STRATEGY IN CENTRAL ACEH DISTRICT
Authors: Fadli  , Emmia Tambarta Kembaren  , Khairul Akbar  , Aulia Rahman  , Ahmad Alwi Piliang
Published: June 2023

Gayo coffee is quite famous in the world because it has a distinctive aroma and enjoyment and if it is cupped or taste tested . Aspects of coffee marketing can be viewed in terms of the type of commodity, actors, supply and demand. In general, the types of coffee marketing products are: (a) coffee grain /labui; (b) arabica coffee beans; (c) coffee grounds, and (d) other processed products. Central Aceh Regency generally produces coffee in the form of Arabica coffee beans (Green bean) while nowadays, the conditions of competition are getting tighter where each country develops their coffee processed products. The strategy for developing Arabica coffee commodities today is expected to be no longer how to increase production, but how a commodity can be processed so that added value is obtained from the processing process. The development of added value in coffee commodities is expected to produce diversified processed coffee products, such as roasted coffee, instant coffee, coffee mix, decaffeinated coffee, soluble coffee, coffee beer (coffee beer), ice coffee which has an important meaning, because it can become a leading commodity that have high competitiveness in the international market. This research was conducted in Central Aceh District. This is because Central Aceh Regency is the main location for processing coffee products in Aceh Province . The research method used is descriptive quantitative research method. The data collection method used was in-depth interviews with several key persons, namely: the trade department, the agriculture office, coffee expert staff, Gayo arabica coffee farmers and four coffee agroindustry green been and coffee powder which has the largest export quota in Bener Meriah Regency, namely KBQB Baburrayyan, Cooperative Oro Coffee, and PT Olam Coffee. The data analysis method used to calculate the added value is the Hayami method. This research resulted in TKT 1 with the output target in the form of (1) scientific publications in index international research journals crossreff with the status accepted, (2) HKI research reports with the status granted, (3) publication of activities in print or online media.
MEMBUMIKAN AL- QURAN PANCASILA DAN ETOS SAINS
Authors: Yulia Alfiani Miranda
Published: June 2023

The pleasure of paradise also hill in general are human busy with himself never thought of the life of the hereafter and continuous, breaking the law moral obligation for the country to establish a security system social where a who are religious namely by zakat play the role of central. Islam attention to the poor is evidence of the holy Quran expressed to the prophet verse, the vision for a leader is not just had to liberate the country but also must be to liberate welfare and prosperity humans are there in which, please help each other between fellow. Everyone who faithful in particular the prophet can adress syaithan temptations, the man who like this is the creation of God they beyond the angel God in the knowledge and in to spiritual, humans in the created on earth has a unique position, in give freedom wills, In order to be his mission of khalifah on earth, among mission is create a the social life on earth, social often connected with a man in society example the man who life in the village, the man who life in the city, it also there to do with a sense of emphaty, help of a rich to poor, help from powerful to a week, In a great line is classified into two things human relationship (verticals relation ship between human with God)  (Horizontal relation ship between humans to humans) if it is good in yourself man, it can be certain someone that will also be good in the side of life, two it had become a benchmark in life, if the social already is well that it appears the life neat, is orderly and have a sense of symphaty and emphaty high. In this word there is no one big and no one little, there was only people who a great personal and a small personal, the purpose of the personality of inside the man could rich himself to be a good person, also able to rich people in the vicinity especially country that he occupy.
CORAK PENAFSIRAN MUHAMMAD QURAISH SHIHAB DALAM TAFSIR AL-MISHBAH
Authors: Agus Setiawan Rahmadi
Published: June 2023

This study aims to analyze the pattern of interpretation of Muhammad Quraish Shihab in Tafsir al-Mishbah. This interpretation is essential to study as one of the products of Nusantara interpretation which is accepted by the wider community. From the initial analysis, it can be seen that Tafsir al-Mishbah uses a multidisciplinary approach to studying and interpreting the Qur'an. The social, rational pattern, which is then analyzed in depth (tahlili) also becomes a prominent characteristic in this interpretation. This can be seen from the style of interpretation which is often reinforced by historical data as a complement to interpretive data or sometimes data from other books such as the Bible and the Torah as a comparison in trying to provide reinforcement in interpreting arguments against the holy verses of the Qur'an. Efforts to interpret this type are pretty influential in understanding the Koran today, although the progressivity towards new interpretations is measured based on the ability of a developing society
The Effect of Motivation and Career Development on Organizational Commitment at Employees PT. XXX
Authors: Jasrol Muhammad , Saputra Darma , Suyono Suyono
Published: June 2023

The purpose of this study was to examine the effect of motivation and career development on organizational commitment among PT. XXX. The research population is 879 employees. This research is associative research, namely research that aims to determine the relationship between two or more variables. With the research instrument, namely the validity test which shows that the data obtained is valid and reliable and the research results show that there is no classical assumption. Research shows that motivation has a value of 4.709 and Adjusted R Square of 0.172. In addition, after conducting the research, the value of tcount > ttable is 2.584 > 1.666. This indicates that motivation has a positive effect on organizational commitment. Career development has a score of 4, 013 and Adjusted R Square of 0.172. In addition, after conducting the research, tcount > ttable is 4.029 > 1.666. This indicates that career development has a positive effect on organizational commitment. Variables of motivation and career development have a positive effect on organizational commitment, this is evidenced by the results of the research Fcount > Ftable, namely 10.234 > 3.10.
The Needs Analysis of Teaching Materials for Writing Short Stories Based on Cerpengram Method for Class IX
Authors: Rosa Utami Dita , Rafli Zainal , Ansoriyah Siti
Published: June 2023

The advancement of science impacts learning innovations that fulfill the requirements for resolving issues in the field of education. The goal of this project is to find instructional resources for writing short stories that are appropriate for class IX students. This research used a descriptive qualitative methodology to collect data using interviews and questionnaires. The findings indicated that there were constraints and a lack of teaching resources for class IX students at SMP Negeri 24 Kerinci to write short stories. The final results indicate that creative teaching tools based on the Cerpengram technique are required to facilitate comprehension of the subject matter, particularly short story writing abilities. According to the requirements analysis, 100% of students and instructors demand novel teaching resources based on the Cerpengram technique that have been produced in the form of e-modules.
The Effect of Financial Performance and Corporate Governance on Extensive of Disclosure Sustainability Reporting
Authors: Permata Dewi Indah , Safitri Arrum , Tri Lestari Saprilia
Published: June 2023

This study aims to analyze the influence of the determinants of disclosure sustainability reporting. The determinants of sustainability reporting classified are financial performance and corporate governance. Financial performance includes company size, profitability, leverage and liquidity. Corporate governance includes the board of directors and audit committee. The data used in this study is secondary data in the form of sustainability report data, annual report and financial statements companies registered on Asia Sustainability reporting Rating (ASRRAT) in 2018-2021 by purposive sampling methods. This study uses a quantitative approach to the method of analysis using multiple linear regression tests.
The effect of C-reactive protein, Procalcitonin and Neutrophil/lymphocyte ratio on mortality in patients hospitalized in the intensive care unit
Authors: Gulsoy Kemal , Orhan Semiha
Published: June 2023

Effectiveness of using inflammatory markers for prognosis assessment in the intensive care units (ICU) is still not clear. The current study aimed to examines the relationship among procalcitonin, C-reactive protein, and neutrophil/lymphocyte ratio of patients who are getting treatment in the ICU during hospitalization and mortality. The study was carried out with a total of 788 patients who were hospitalized in the ICU longer than a day. All participants were over the age of 18 years old. C-reactive protein, procalcitonin, and neutrophil/lymphocyte ratios were compared between the groups of those who died and those who were discharged from the ICU.54.6% (n= 430) of 788 patients who were admitted to the study, were male whereas45.4% (n= 358) of them were female. The median age of the study group was calculated as 79 years (IQR = 19 years) (P<0,001). The univariate Cox regression analysis performed to examine the parameters affecting mortality, the analysissuggested following P-values for the procalcitonin, C-reactive protein, and neutrophil/lymphocyte ratio; <0.001, 0.887, and 0.014 respectively. Conversely, the multivariate Cox regression analysis which is performed to examine the parameters affecting mortalityyielded following P-valuesfor the same variables respectively: 0.242, 0.116, and 0.523. Although inflammatory markers (i.e.,C-reactive protein, procalcitonin, and neutrophil/lymphocyte ratios) were high in patients who died, their relationship with mortality in the ICU could not be shown.
Short-term comparison of intraarticular administration of IL-1 receptor antagonist and platelet-rich plasma for osteoarthritis treatment
Authors: Guler Yasin , Kuyucu Ersin , Kara Adnan , Hakyemez Omer , Say Ferhat , Bulbul Ahmet
Published: June 2023

Osteoarthritis (OA) is a prevalent joint condition that affects areas such as the knee, hip, hand, and spine. In treating mild to moderate cases of OA, treatment options such as intraarticular corticosteroids, viscosupplementation, glucosamine and chondroitin sulfate, PRP, and IL-1Ra are commonly used. This study aimed to compare the effects of IL-1 receptor antagonist (IL-1Ra) and platelet-rich plasma (PRP) on patients with Kellgren-Lawrence (KG) stage 2-3 knee osteoarthritis in terms of Visual Analog Scale (VAS) and Knee injury and osteoarthritis outcome score (KOOS). Ninety patients with KG stage 2-3 knee primary osteoarthritis were divided into two groups, with one group receiving three intraarticular IL-1Ra injections and the other group receiving three PRP injections. VAS and KOOS scores were recorded at the beginning and after six months to evaluate clinical improvement. Both the IL-1Ra and PRP groups showed statistically significant improvement in all scores, including the VAS and KOOS. After six months, the KOOS score in the IL-1Ra group was significantly higher than the PRP group, while the first-year VAS score after treatment in the IL-1Ra group was significantly lower compared to the PRP group. The mean KOOS scores increased from 44.1 to 87.8 and 46.04 to 84.43 at the end of six months in both groups, while the mean VAS scores decreased from 7.27 to 1.02 and 7.29 to 1.71 in the IL-1Ra and PRP groups, respectively. Administering intra-articular IL-1Ra once a week for three weeks can effectively improve function and reduce pain in patients with Kellgren-Lawrence stage 2-3 osteoarthritis. However, more research is necessary to validate the use of IL-1 receptor antagonists in OA treatment.
Is tacrolimus effective against choroidal neovascularization? A preliminary study
Authors: Kivilcim Muhamet , Aydin Erdinc , Altan Volkan
Published: June 2023

To evaluate the effectiveness of tacrolimus used topically in inhibiting a rat model of laser-induced choroidal neovascularization. Thirty-six Long-Evans pigmented rats were utilized in this paper. Bursting lesions are performed on the retina of one eye in each animal to induce choroidal neovascularization (CNV) by argon laser. The animals were separated into 3 groups of 36 rats. Twelve animals in each group and one eye per animal were topically administrated daily for 5 weeks at 0.3%, 0.5% tacrolimus, and saline respectively. Fluorescein angiography (FA) was performed in groups 1, 2, and 3 (control group) in the 3rd week, 4th week, and 5th week after the initial retinal photocoagulation. FA is graded for each of the three lesions as follows: score 0: no leakage, score 1: slight leakage, score 2: moderately leakage, and score 3: strong leakage. At the end of the study, the eyes were enucleated and prepared for histological examination. According to fluorescein angiography (FA) score comparisons, in group 1 (topical 0.3 % Tacrolimus) there was only a significant difference between its controls at the 5th week after retinal photocoagulation (p=0.05). In group 2 (topical 0.5 % Tacrolimus) there was a significant difference when compared to control eyes in the 4th week and the 5th week (p=0.018, p=0.021). Topical instillation of tacrolimus at a concentration of 0.5% following the laser photocoagulation significantly reduced leakage of CNV versus controls in the 4th and the 5th weeks, the time points tested. Tacrolimus at a concentration of 0.3 % significantly reduced CNV only 5 weeks after retinal photocoagulation. These results show that there is a dose-response of topical tacrolimus on the suppression of CNV. Tacrolimus is a well-penetrating drug through the cornea and following topical administration, can reach effective concentrations depending on application way and dose. This study needs to be performed in other experimental models and then clinical trials.
The knowledge levels, sociodemographic characteristics and the reasons for application to the first stage during the COVID-19 pandemic patients who applied to a family medicine clinic in Istanbul
Authors: Cakmak Selin
Published: June 2023

It is to evaluate whether there is any change in the community's applications to primary care in the Covid-19 pandemic and to evaluate the level of knowledge of patients about Covid-19 in this important process. A total of 331 female and male volunteers between the ages of 18-80 who applied to a family medicine unit on the European side of Istanbul between September 2020 and November 2020 were included in the study. 30 questions in the questionnaire were filled by a single investigator after the patients were informed and their consent was obtained. This study, which we conducted in the early days of the Covid-19 pandemic, showed us that; The most important means of communication in making the pandemic known to the public are TV and social media (87.3%). Thanks to the full closure and other protective measures implemented in the early days of the pandemic, a controlled increase in the number of cases was observed, and the number of people who caught Covid-19 among the people who participated in our survey was quite low (3%) and most of these people were treated at home (62.5%). The epidemic process also affected hospital admissions of people, and it was seen that the number of people who did not apply to the hospital for more than 1 month was the majority (74.9%). One of the remarkable ones among the answers to the Covid-19 information questions; although there is no specific treatment for Covid-19 yet, 209 people (63.1%) say that there is a cure for Covid-19. We think that the preventive treatment (Hydroxychloroquine and Favipiravir) applied by the filiation teams, even if there is no specific treatment, is effective in these discourses. However, although the vaccine studies have not been concluded yet, 34 (10.3%) people stated that the vaccine was available.
Desire avoid of pregnancy in nulliparous women: The effect of personality and sociodemographic characteristics
Authors: Guney Esra , Okyay Esra
Published: June 2023

The study was aim to determine the effect of personality and sociodemographic characteristics on the avoidance of pregnancy by nulliparous women. The cross-sectional study was conducted through nullipar women's groups on social media platforms (Instagram, Facebook Messenger and WhatsApp etc.). 602 women who volunteered to fill out the questionnaire participated in the study, whose sample consisted of women who had not given birth before, and the study data were collected in November 2022. Data collection forms were created using the Google forms application. Personal Information Form, Ten-Item Personality Inventory (TIPI), and Desire to Avoid Pregnancy (DAP) were used to collect the data. Mean, percentile distribution, standard deviation, t test, one-way ANOVA and simple linear regression analysis were used for statistical analysis. In the study, it was determined that those who were 21 years of age and under, those with a high education level, those who were not working, those who did not think about giving birth, and those who planned a cesarean delivery in the future had higher pregnancy avoidance scores (p<0.05). The simple linear regression model showed that age, education level, future pregnancy planning status, planned future birth, openness to experiences and conscientiousness personality traits are important determinants of the desire to avoid pregnancy in women (respectively β=-.0.379; β=0.118; β=-0.345; β=0.107; β=0.202; β=0.203; p<0.001 for all; p<0.05 for birth planned in the future only). Pregnancy avoidance can be seen in nulliparous women who are 21 years of age or younger, have a high level of education, are not working, do not think about giving birth, have a low desire to conceive in the future, plan a future cesarean section, have openness to experiences and conscientiousness personality traits.
Investigation of protective roles of myricetin and quercetin against nephrotoxicity caused by malathion intoxication in rats
Authors: Berkoz Mehmet , Volkan Davut
Published: June 2023

In this study, the protective roles of myricetin (MYC) and quercetin (QRS) against nephrotoxicity caused by malathion (MLT) intoxication were investigated. A total of 42 male rats were used and divided into 6 groups. The dose of MLT was fixed at 108 mg/kg/day and MYC or QRS were administered separately at doses of 100 and 200 mg/kg/day. All chemicals were orally administered for 28 days. At the end of the study, sera and kidney tissues were obtained. Serum urea, creatinine and uric acid levels, kidney malondialdehyde (MDA), nitric oxide (NOx), protein carbonyl (PCO), 8-hydroxy-2'-deoxyguanosine (8-OHdG), prostaglandin E2 (PGE2), reduced glutathione (GSH), catalase, superoxide dismutase (SOD), glutathione redustase (GSH-Rx), glutathione peroxidase (GSH-Px), paraoxonase (PON), and arylesterase (ARE) levels were measured as well as histological examinations in kidney tissue were performed. MLT treatment increased serum urea and creatinine with increased levels of kidney MDA, NOx, PCO, 8-OHdG, PGE2 and decreased levels of catalase, SOD, PON, ARE, GSH, and GSH-Px in the kidney (p<0.05). Also, MLT intoxication disrupted the histological structure of kidney tissue. MYC and high concentration of QRS were able to reverse this effect by reducing oxidative stress in the kidney and improving the histology of kidney tissue (p<0.05). In conclusion, MLT caused an increase in oxidative stress and inflammatory response with impaired kidney functions in rats, but MYC and QRS treatments can prevent MLT-induced nephrotoxicity in rats.
Successful ERCP application in pregnant women with cholestasis
Authors: Aladag Hulya , Aladag Murat
Published: June 2023

We aimed to present successful endoscopic retrograde cholangiopancreatography (ERCP) applications and results in our pregnant cases. A retrospective analysis was performed on the data of 14 successful ERCP procedures performed on our pregnant patients between 2016 and 2022. The ERCP operation was carried out on the patients while they were in the left decubitus position by endoscopists skilled in biliary endoscopy. Methods to lessen prenatal radiation exposure were used during the fluoroscopy procedure. Throughout the process, short-term fluoroscopies were employed. The duration of each fluoroscopy on the patient was noted.
14 pregnant women who presented with cholestasis results had ERCP and sphincterotomy. Two of the procedures were completed on full patients during the appropriate trimesters. Our pregnant women had a mean gestational age of 17.8 weeks and a mean mother age of 24.85.6 (19-38). The fluoroscopy took 0.16 minutes (0-35sec). Ten pregnant women (10 sec) had very little fetal radiation exposure, while four other pregnant women (4 sec to 14 sec) had some.
The two women's combined prenatal radiation exposure was reportedly between 30 and 35 seconds. One mild bleeding after sphincterotomy, two hyperamylasemia following ERCP, and one case of acute respiratory distress syndrome were procedure-related complications. Two days after an ERCP, cholecystitis manifested in one pregnant woman.
When measures are taken as directed by a multidisciplinary team, ERCP can be used during pregnancy without risk and produce positive outcomes.
Effects of mirtazapine on cisplatin cardiotoxicity in rats
Authors: Ozhan Onural , Ulutas Zeynep , Serduman Seray , Buyukkorkmaz Leyla , Yildiz Azibe , Ulu Ahmet , Vardi Nigar , Ates Burhan , Parlakpinar Hakan
Published: June 2023

Atypical antidepressant mirtazapine (MIR) is primarily used to treat major depressive disorder. It has not been clarified whether cardiovascular uncertainties and mechanisms of action emerge as problems during the use of mirtazapine. Cisplatin (CIS) is an effective anti-cancer medication used to treat a variety of human malignancies. There were four groups of 32 Wistar albino male rats in all. Rats were split into 4 groups at random. 1. Control Group, 2. CIS Group, 3. MIR Group, 4. MIR+CIS Group. On the 15th day of the study, ECG, heart rate, and blood pressure were determined. Histopathological and biochemical analyses were carried out on cardiac and vascular tissue samples. Comparing the CIS group to the other groups, blood pressure was considerably lower in the CIS group (p<0.05). In vascular tissue examination, catalase and superoxide dismutase levels were substantially higher in the control, MIR, and MIR+CIS groups, similar to those of the myocardium, compared to the CIS group (p<0.05). While the CIS group had the highest malondialdehyde level, it was much lower in all other groups in both myocardial and vascular tissue (p<0.05). It was observed that the congestion persisted, but the interstitial edema's intensity was much less severe in the MIR+CIS group than in the CIS group (p=0.009). We sought to clarify the function of the oxidative system, tissue-level histological alterations, the possibility that mirtazapine protects against CIS cardiotoxicity, and the role of MIR in cardio-oncology in this study. In this study, we demonstrated the possible protective effect of MIR in CIS-mediated cardiotoxicity and its antioxidant effect mechanism.
Evaluation of knowledge, attitudes, and behaviors of non-physician healthcare professionals about breast cancer screening program
Authors: ILHAN Yusuf , BALCIK Onur
Published: June 2023

Cancer screening programs are carried out worldwide and in our country to diagnose breast cancer in its early stage, before the disease shows any symptoms. In this study, we aimed to evaluate the knowledge, attitudes, and behaviors of non-physician healthcare professionals about breast cancer screening programs. This study was planned as a cross-sectional survey study, nurses and female non-physician hospital staff from different professions were included. In addition to primary demographic data, various questions were asked to the participants to evaluate their knowledge about breast cancer screening programs and compliance with breast cancer screening programs, and then the data were analyzed. A total of 332 volunteers were included in our study. 317 (95.5%) of them stated that they had heard of the Cancer Early Diagnosis, Screening, and Education Centers (KETEM) before. When asked whether cancer screenings were essential, 327 (98.5%) of the volunteers answered “Yes,” considering it is essential, and thus it was thought that non-physician healthcare professionals had a high awareness of this issue. Fifty (15.1%) of the non-physician healthcare professionals stated that they regularly performed breast self-exams once a month, 83 (25.0%) did not do any breast examination, and 154 (46.4%) did it sporadically. Of the population, 66 people were 40 years and older. In this population, 33 (50.0%) of the participants answered “Yes” to the question “Have you ever had a mammogram?”; whereas 33 (50.0%) of them answered “No.” In general, the awareness of the participants was high, but it was thought that their level of knowledge about breast cancer screening was insufficient. In addition, it was observed that the compliance rates to cancer screening programs were insufficient. Therefore, an absolute effort should be made to increase the knowledge and awareness of health professionals who play an essential role in public health.
Shared dissociative identity disorder and defector alter personality: controlled human syndrome and the objectification trap phenomenon as a gaslighting form based on dissociative narcissism from the perspective of dissoanalysis theory and dissoanalytic psychohistory
Authors: Ozturk Erdinc
Published: June 2023

In today's age of global dissociation, it has become necessary to deal with the social and clinical aspects of dissociation, which is a "psychosocial denial experience" in terms of ideational, emotional, relational, behavioral and sensory aspects. In dysfunctional nations experiencing psychosocial denial, democracy unfortunately functions as the majority's freedom to make wrong decisions. The freedom of the majority to make wrong decisions creates “dissociative and misanthropic masses” and causes “universal violence circulation” and despotism to prevail. Dissoanalysis and “Ozturk’s Pervasive and Reversible Dissociative Fusion Theory” define the universal circulation of violence as a reversible “dissociative violence oscillation” associated with trauma, which spreads from individual to society and from society to individual. The submissive mode associated with the experience of connecting to their oppressors and dictators is contagious; it spreads from traumatized and dysfunctional individuals to dissociated and dysfunctional societies, creating fused interpersonal relationships and both conformist and sadomasochistic masses. The dissoanalytic school defines the phenomenon of dissociation, which is most closely related to chronic, complex and cumulative traumatic experiences, which can transform from the individual to the social dimension and from the social dimension to the individual dimension in the face of oppression, and even be experienced simultaneously in the individual and social dimensions, both in relational and psychosociopolitical contexts. Dissoanalytic psychohistory, which continues its development rapidly in parallel with the principles of dissoanalysis and modern psychotraumatology, has far outstripped the stable and dogmatic schools of psychiatry, psychology, and history with its integrative solution-oriented approaches and effective psychosocial prevention strategies towards the phenomenon of trauma-related dissociation and individual and mass obedience cycles against oppression. In this original article, Ozturk defined the phenomenon of “objectification trap”, “controlled human syndrome” and “shared dissociative identity disorder” as the triple pillar of fused bilateral relations dominated by reversible dominative and submissive modes from the perspective of dissoanalysis theory and dissoanalytic psychohistory.
The Effect Of Emotional Intelligence And Work Experience On Job Satisfaction
Authors: Inez Aprilianti  , Dedy Dewanto
Published: June 2023

This research was conducted on Non-Manager employees of PT. Pertamina Training and Consulting, in which all employees must be able to work as a team so that the set organizational goals are achieved. When employees have weak emotional intelligence, their job performance can be affected and affect job satisfaction. The more years of service an employee has, the greater his work experience so that it affects his ability and job satisfaction. This study aims to determine the effect of emotional intelligence and work experience on job satisfaction. This study uses a quantitative approach with a questionnaire method and field research. There are 266 non-manager employees in the company, where the number of research samples as respondents is 165 people using the convenience sampling technique and the slovin formula. Data analysis techniques used validity test, reliability test, classical assumption test, multiple linear regression analysis and hypothesis testing. The results of the study through the F test show that emotional intelligence and work experience have a significant effect on job satisfaction. On the other hand, through the t test the results show that the emotional intelligence variable has no significant effect on job satisfaction, while the work experience variable has a significant effect on job satisfaction. However, based on the description data, the main respondents are male aged 21-30 years, with 1-5 years of work experience, and the majority of them have bachelor degree education, who are typically energetic and need a challenge so it takes time to assess deeply about job satisfaction from side of work challenges, promotions, support from colleagues, and superiors. That is the possibility why emotional intelligence has no significant effect on job satisfaction.
The EU at a Strategic Crossroads: A Geopolitical Player in Great Power Games?
Authors: Marinova Iren
Published: June 2023

The current shifts in the post-Cold War international order are bringing the attention to notions of great power competition, demonstrating once again the geopolitical significance of Europe and Asia for global politics. This article applies concepts from the classical geopolitical thinking of Halford Mackinder and Nicholas Spykman as an ‘optic tool’ for analysing current global events and for considering the European Union’s (EU’s) strategic direction in light of the interests of the United States, Russia, and China in Europe’s wider region. With the American post-Cold War global preponderance steadily waning and the rising challenges from the east in the face of Russia and China, the EU finds itself in a position that requires the redefinition of its geopolitical identity and strategic pursuit of its own interests. A look through the classical geopolitical concepts of the Heartland and the Rimland reveals that the EU is an extraordinary player in geopolitics as it has the potential to determine (1) access to the Eurasian Heartland via its influence over Eastern Europe and (2) control of the maritime Rimland by virtue of its geography, alliances, and its potential participation in Beijing’s New Silk Road initiative. These findings are discussed by considering the EU’s potential foreign policy directions vis-à-vis the US, Russia, and China.

European Union, United States, Russia, China, Eurasia, Geopolitical theory, Foreign policy, Grand strategy, Strategic Autonomy
The Personal Data Under the GDPR: Concept, Elements, and Boundaries
Authors: Cordeiro A. B. Menezes
Published: June 2023

The concept of personal data plays a foundational role in data protection law. The application of the General Data Protection Regulation (GDPR), as well as virtually all other national or transnational legislation that regulates the processing of personal data, depends on the identification of an actual personal data. Despite being a concept that is perfectly consolidated, especially within the European Union, its exact boundaries continue to raise some questions from an application point of view, particularly with regard to the element of identifiable.

In this article, we intend to examine the origins of the concept of personal data and analyse its various elements and boundaries under the GDPR

data protection, privacy, personal data, GDPR, identifiable information
Safeguard Activity in 2022: An Overview of Notifications Made to the WTO Committee on Safeguards
Authors: Piérola-Castro Fernando
Published: June 2023

In this note, the author presents a summary of the most important safeguard-related developments notified to the WTO Committe on Safeguards for the year 2022.

safeguard notifications, Committee on Safeguards, initiation of investigation, finding of serious injury, decision to impose a safeguard measure
In Dubio Pro Tributario/In Dubio Mitius as a Rule of Reasoning in Tax Law Interpretation
Authors: Morawski Wojciech , Boháč Radim
Published: June 2023

The is devoted to the principle of in dubio pro tributario (the principle of resolving doubts in favour of the taxpayer) as a rule of legal reasoning. The article points out its following two aspects: (1) the evidential aspect whereby it is concerned with resolving uncertainties regarding the proof of facts that are relevant to the determination of the amount of tax and (2) the interpretative aspect whereby it is used to resolve doubts related to the ambiguity of a legal regulation. The article focuses on the second aspect. The authors present how various legal systems have developed different ways of understanding this principle. They point out that it is not a universally applied principle in tax law and that it has been rejected in the case law of the Court of Justice of the European Union (CJEU).

interpretation, in dubio pro tributario, in dubio mitius, tax law, tax avoidance, EU law
Comparing Comparability: A Study of EU, ISDS, and WTO Tax ‘Like’ Cases
Authors: Castagna Stefano
Published: June 2023

This article addresses the fundamental element of non-discrimination provisions, i.e., the comparability analysis. Comparisons of treatment between different persons, goods, services, and capital that are present within a specific market are necessary to ensure a level playing field for competition within a globalized world. Comparability analyses are often the deciding factor of cases, and thus a thorough understanding of how they work is essential for practitioners and academics alike. This kind of test is present within several types of international treaties and is often the subject of intense debate and discussion within case law. This is in spite of the fact that there are few cases in which comparability is assumed without any type of analysis whatsoever. This work performs a comparative analysis of comparability analyses throughout the different international regimens of the European Union, Investor-State Dispute System (ISDS), and World Trade Organization (WTO) within the context of tax disputes. For each, it considers the peculiarities of the system, analysing case law, and proposes a way to further the fairness and specificity of comparability analysis. It also proposes the possible implementation of a different comparability analysis based on the impact on value created by companies from a given measure.

Comparability analyses, EU, WTO, ISDS, ROIC, transfer pricing, international taxation, dispute resolution, litigation, likeness.
DIAGNÓSTICO DOS RESÍDUOS SÓLIDOS PRODUZIDOS EM FEIRAS DE PEQUENOS PRODUTORES
Authors: Tessaro Cristiane Renata , Korf Eduardo Pavan , Locatelli Débora Regina Schneider
Published: June 2023

As feiras são importantes mecanismos de comercialização e a geração de resíduos sólidos é um problema que precisar ser considerado pelos gestores. Tendo em vista a carência de estudos nesta temática, a presente pesquisa teve como objetivo diagnosticar o gerenciamento dos resíduos sólidos produzidos em feiras de pequenos produtores para auxiliar na elaboração de planos de gerenciamento. A pesquisa foi desenvolvida em duas feiras localizadas no município de Erechim-RS, Feira da Agricultura Familiar Nossa Terra e Feira do Produtor, localizadas no bairro Centro. As amostras de resíduos foram coletadas em períodos distintos e os resíduos foram caracterizados por meio da composição gravimétrica, volume diário e a geração per capita. Foi verificado também as etapas de manejo dos resíduos nas feiras, isto é, como é realizado o acondicionamento, transporte e destino final, e por fim, foram propostas diretrizes para a elaboração de planos de gerenciamento de resíduos sólidos em feiras similares. A geração média diária de resíduos das coletas resultou em 343,65 kg para a Feira da Agricultura Familiar Nossa Terra e 162,95 kg para a Feira do Produtor. Desses mais de 95% são resíduos sólidos orgânicos. A produção per capita resultou em 0,10 kg/pessoa para a feira do Produtor e para a Feira da Agricultura Familiar Nossa Terra uma produção per capita de 0,22 kg/pessoa. Pode-se concluir que o acondicionamento é inadequado nas duas feiras, pela falta de local apropriado ou de lixeiras e ou, ainda, de conscientização da população em geral incluindo feirantes e consumidores. Portanto, pode-se inferir que através dos dados obtidos pelo estudo, que eles podem contribuir para melhorar a gestão dos resíduos sólidos em feiras similares às estudadas no Brasil e no mundo, em consonância com planos de gestão integrada de resíduos sólidos urbanos e com o que prevê o ODS número 11 da agenda 2030.
SHARENTING E A (IN)VIOLABILIDADE DO DIREITO DE PERSONALIDADE: ASPECTOS QUANTO A ATUAÇÃO DA REDE DE PROTEÇÃO DOS DIREITOS DA CRIANÇA E DO ADOLESCENTE
Authors: Alvarenga Fabiana Riccato Vicente , Rocha Jakeline Martins Silva
Published: June 2023

O excesso de publicização de informações pessoais dos filhos nas redes sociais pelos pais ou responsáveis configura o “sharenting” e constitui problema jurídico, uma vez que os dados inseridos na internet, permanecem ali e podem ser acessados por muito tempo após à publicação, tanto pelo titular (quando adulto) quanto por terceiros. Tais informações podem causar impactos desde a infância até a vida adulta, considerando que o indivíduo pode desaprovar a conduta dos seus pais por entender que teve sua vida privada exposta indevidamente durante a infância. Neste contexto, importa analisar a (in)violabilidade  dos direitos da personalidade dos filhos com base no conflito entre os princípios da autonomia da vontade dos responsáveis e o melhor interesse dos infantes e quais estratégias vem sendo adotadas pela rede de proteção dos direitos das crianças e adolescentes para evitar as possíveis violações decorrentes do fenômeno comportamental denominado “sharenting”.
AS TIRINHAS NO ENSINO DA GEOGRAFIA E A DIVERSIDADE CULTURAL DENTRO DA SALA DE AULA
Authors: Júnior Manuel Fernandes França
Published: June 2023

O presente artigo buscou retratar sobre a importância de utilizar um material didático visual nas aulas de Geografia, como as tirinhas, para abordar sobre a diversidade cultural que existe dentro das salas de aulas.  Trouxe ainda, resultados da pesquisa com o intuito de contribuir com uma nova didática para o ensino, no qual a diversidade cultural deve ser trabalhada com o auxílio das tirinhas geográficas, visando contribuir para um ensino igualitário e promover uma reflexão crítica em sala de aula.
Examining the Impact of Interest Rate, Inflation and Balance of Trade on Saudi Arabia’s Financial Markets Performance
Authors: knio mohamad , El Hajjar Said , M Antony Jaishu
Published: June 2023

A confirmatory framework, utilizing the positivist standpoint, provides clarifications of the issue at hand. Investigating the impact of the macroeconomic factors on the profits of Saudi Arabia’s stock exchange was developed. Following thorough research, it became clear that a correlative study was required. Secondary data, gathered from to 2006 to 2021, was interpreted through regression analysis for the purpose of the study. As such, a numerical examination was conducted in order to observe the correlation of the macroeconomic variables and changes in Saudi Arabia’s stock market. The findings results indicate that the balance of trade has a consequence on Saudi Arabia’s stock exchange performance. The aim of this study is to improve the level of understanding of the stock market behavior for entrepreneur, stock market decision maker, whereas deterrent measures in contrast to the risk comprised in stock market performance can be taken by the establishments.
Sustainability Reporting Practices in UAE Business Firms, the Society, and Stakeholders' Insights
Authors: Eltom Abubaker , Yatiban Aminurraasyid , Rusdi Omarc
Published: June 2023

Organizations are complex entities that operate with a set of internal regulations, instructions, procedures, and achievements that contribute to the successful execution of their goals and objectives. However, these accomplishments may not be widely known, even among most employees, since the effectiveness of organizations is largely dependent on the level of culture and engagement within the organization. In addition to internal operations, organizations must also consider their external relat