bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictability of Intraocular Lens Power Calculation for Cataract with Keratoconus: A Multicenter Study
Authors: Kamiya Kazutaka , Iijima Kei , Nobuyuki Shoji , Mori Yosai , Miyata Kazunori , Yamaguchi Takefumi , Shimazaki Jun , Watanabe Shinya , Maeda Naoyuki
Published: January 2018

This study was aimed to assess the predictability of intraocular lens (IOL) power calculation after cataract surgery for keratoconus. We retrospectively reviewed the clinical charts of 102 eyes of 71 consecutive keratoconic patients who developed cataract. We determined manifest spherical equivalent, prediction errors, and absolute errors, 1 month postoperatively. The achieved refraction was significantly more hyperopic than the targeted refraction, when keratometric readings were used (p = 0.001). At 1 month, 36% and 63% of the eyes were within ±0.5 and ±1.0 D, respectively, of the targeted correction. We found a significant correlation between the prediction error and the mean keratometry (Pearson correlation coefficient r =−0.545, p < 0.001). No vision-threatening complications occurred in any case. The achieved refraction was significantly more myopic than the targeted refraction, when total corneal refractive power was used (p = 0.013). Phacoemulsification with IOL implantation appeared to be safe and effective, and the accuracy was also good in mild keratoconus, but not in severe keratoconus. It should be noted that that a large amount of hyperopic shift occurred especially in advanced keratoconic patients, when keratometric readings were used for IOL power calculation, and that a slight, but significant, myopic shift occurred, when total corneal refractive power was used.
Recombinant human B cell repertoires enable screening for rare, specific, and natively paired antibodies
Authors: Rajan Saravanan , Kierny Michael R. , Mercer Andrew , Wu Jincheng , Tovchigrechko Andrey , Wu Herren , Dall′Acqua William F. , Xiao Xiaodong , Chowdhury Partha S.
Published: January 2018

The human antibody repertoire is increasingly being recognized as a valuable source of therapeutic grade antibodies. However, methods for mining primary antibody-expressing B cells are limited in their ability to rapidly isolate rare and antigen-specific binders. Here we show the encapsulation of two million primary B cells into picoliter-sized droplets, where their cognate V genes are fused in-frame to form a library of scFv cassettes. We used this approach to construct natively paired phage-display libraries from healthy donors and drove selection towards cross-reactive antibodies targeting influenza hemagglutinin. Within 4 weeks we progressed from B cell isolation to a panel of unique monoclonal antibodies, including seven that displayed broad reactivity to different clinically relevant influenza hemagglutinin subtypes. Most isolated antibody sequences were not detected by next-generation sequencing of the paired repertoire, illustrating how this method can isolate extremely rare leads not likely found by existing technologies.
A turn-on near-infrared fluorescence probe with aggregation-induced emission based on dibenzo[a,c]phenazine for detection of superoxide anions and its application in cell imaging
Authors: Yang Ji , Liu Xianglong , Wang Honglei , Tan Haoqi , Xie Xiaoxu , Zhang Xiao , Liu Chenchen , Qu Xue , Hua Jianli
Published: January 2018

A new turn-on near-infrared fluorescence probe (BDP) based on dibenzo[a,c]phenazine for superoxide anion detection with AIE properties and a large Stokes shift was developed.
Selecting optimal features from Fourier transform infrared spectroscopy for discrete-frequency imaging
Authors: Mankar Rupali , Walsh Michael J. , Bhargava Rohit , Prasad Saurabh , Mayerich David
Published: January 2018

Augmenting tissue histology with spectral information from mid-IR spectroscopy will benefit a lot. Optimal bands selection needed to do histopathological classification of mid-IR images will help to reduce imaging time and computation complexity. GPU use for feature selection makes it practical.
Dendritic phospholipid-based drug delivery systems
Authors: Jiang Lei , Chen Weizhi , Zhou Sensen , Li Cheng , Zhang Xiaoke , Wu Wei , Jiang Xiqun
Published: January 2018

A class of new dendritic phospholipid compounds with different hydrophilic dendritic poly(l-lysine) peripheries from generations 1 (G1) to 3 (G3) (DPL-1 to DPL-3) were synthesised and nano-drug delivery systems based on these compounds were prepared (DPN-2 and DPN-3).
Nanocomposite injectable gels capable of self-replenishing regenerative extracellular microenvironments for in vivo tissue engineering
Authors: Nagahama Koji , Oyama Naho , Ono Kimika , Hotta Atsushi , Kawauchi Keiko , Nishikata Takahito
Published: January 2018

Nanocomposite injectable gels, which self-replenish regenerative extracellular microenvironments within the gels in the body by utilizing host-derived bioactive molecules as building blocks, are reported.
Naphthalimide derivatives as multifunctional molecules for detecting 5-formylpyrimidine by both PAGE analysis and dot-blot assays
Authors: Wang Yafen , Liu Chaoxing , Yang Wei , Zou Guangrong , Zhang Xiong , Wu Fan , Yu Shuyi , Luo Xiaomeng , Zhou Xiang
Published: January 2018

An azide and hydrazine tethered to a naphthalimide analogue was created to selectively react with 5-formyluracil in one system and fluorogenically label 5-formylcytosine in another system.
The synergistic effect of Ceria and Co in N-doped leaf-like carbon nanosheets derived from a 2D MOF and their enhanced performance in the oxygen reduction reaction
Authors: Xia Wei , Li Jingjing , Wang Tao , Song Li , Guo Hu , Gong Hao , Jiang Cheng , Gao Bin , He Jianping
Published: January 2018

Novel two-dimensional Ceria@Co, N-doped leaf-like porous carbon nanosheets (Ce–HPCNs) and their enhanced performance in the oxygen reduction reaction.
Modular tripodal receptors for the hydrosulfide (HS−) anion
Authors: Lau Nathanael , Zakharov Lev N. , Pluth Michael D.
Published: January 2018

3-fold symmetric receptors with N–H and C–H bond donors enable reversible HS− binding.
A copper-catalyzed reaction of 3-diazoindolin-2-imines with 2-(phenylamino)ethanols: convenient access to spiro[indoline-3,2′-oxazolidin]-2-imines
Authors: Sheng Guorong , Ma Shicong , Bai Songlin , Mao Jianming , Lu Ping , Wang Yanguang
Published: January 2018

3-Diazoindolin-2-imines reacted with chiral 2-(phenylamino)ethanols under copper catalysis to furnish chiral spiro[indoline-3,2′-oxazolidin]-2-imines in good yields with excellent diastereoselectivity.
Label-free and ultrasensitive detection of polynucleotide kinase activity at the single-cell level
Authors: Liu Meng , Ma Fei , Zhang Qianyi , Zhang Chun-yang
Published: January 2018

We develop a label-free fluorescence method for the polynucleotide kinase assay at the single-cell level based on phosphorylation-triggered isothermal exponential amplification.
Rock the nucleus: significantly enhanced nuclear membrane permeability and gene transfection by plasmonic nanobubble induced nanomechanical transduction
Authors: Li Xiuying , Kang Peiyuan , Chen Zhuo , Lal Sneha , Zhang Li , Gassensmith Jeremiah J. , Qin Zhenpeng
Published: January 2018

Nanomechanical transduction increases permeability of the nuclear membrane and facilitates nuclear uptake of macromolecules that would otherwise not enter the nucleus.
Enhancing lithium-ion conductivity in NASICON glass-ceramics by adding yttria
Authors: Vizgalov Victor A. , Nestler Tina , Trusov Lev A. , Bobrikov Ivan A. , Ivankov Oleksandr I. , Avdeev Mikhail V. , Motylenko Mykhaylo , Brendler Erica , Vyalikh Anastasia , Meyer Dirk C. , Itkis Daniil M.
Published: January 2018

The lithium conductivity of NASICON glass-ceramic electrolytes can be increased 5 times just by using additives, which change the glass crystallization patterns.
Oriented surface nucleation and crystal growth in a 18BaO·22CaO·60SiO2mol% glass used for SOFC seals
Authors: Wisniewski Wolfgang , Thieme Christian , Müller Ralf , Reinsch Stefan , Groß-Barsnick Sonja-M. , Rüssel Christian
Published: January 2018

Oriented nucleation of walstromite as well as an unknown phase of the composition BaCaSi3O8is detected after crystallizing a 37BaO·16CaO·47SiO2(wt%) glass.
Property prediction and pharmacokinetic evaluation of mixed stoichiometry cocrystals of zafirlukast, a drug delivery case study
Authors: Corner Philip A. , Berry David J. , McCabe James F. , Barbas Rafael , Prohens Rafel , Du Hongwen , Zhou Hongyu , Llinas Antonio
Published: January 2018

Cocrystals have been identified as a method for ensuring the delivery of poorly soluble drugs.
Multiionic effects on the capacitance of porous electrodes
Authors: Jiménez M. L. , Ahualli S. , Arenas-Guerrero P. , Fernández M. M. , Iglesias G. , Delgado A. V.
Published: January 2018

Tiny amounts of divalent ions considerably reduce the efficiency in desalination and energy extraction techniques based on porous electrodes.
High-pressure and temperature dependence of the spontaneous resolution of 1,1′-binaphthyl enantiomers
Authors: Roszak Kinga , Katrusiak Andrzej
Published: January 2018

High pressure stabilizes the 1,1′-binaphthyl enantiomers and racemate, as evidenced by their recrystallizations and crystal structures up to 3.0 GPa.
Structural transformations of carbon and boron nitride nanoscrolls at high impact collisions
Authors: Woellner C. F. , Machado L. D. , Autreto P. A. S. , de Sousa J. M. , Galvao D. S.
Published: January 2018

The behavior of nanostructures under high strain-rate conditions has been the object of theoretical and experimental investigations in recent years.
Topological behaviour of ternary non-symmorphic crystals KZnX (X = P, As, Sb) under pressure and strain: a first principles study
Authors: Parveen Atahar , Narsimha Rao E. , Adivaiah B. , Anees P. , Vaitheeswaran G.
Published: January 2018

Anab initiostudy on the impact of hydrostatic pressure and strain on the electronic properties of an unexplored class of ternary Zintl phases KZnX (X = P, As, Sb) is reported.
Bimetallic Rh–Fe catalysts for N2O decomposition: effects of surface structures on catalytic activity
Authors: Chen Hao , Lu Qinghua , Yi Chunhai , Yang Bolun , Qi Suitao
Published: January 2018

Well-homogenized RhFe alloy nanoparticles and core–shell structured Fe@Rh nanoparticles were highly dispersed on SBA-15 and then applied to N2O catalytic conversion.
Crystal structures of uranyl complexes with isobutyrate and isovalerate anions
Authors: Savchenkov Anton V. , Vologzhanina Anna V. , Dmitrienko Artem O. , Zubavichus Yan V. , Pushkin Denis V. , Serezhkina Larisa B. , Serezhkin Viktor N.
Published: January 2018

Types of sodium coordination, depolymerization of metal–oxygen frameworks and coordination sequences are analyzed for establishing correlations between composition and crystal structure in the family of analogous compounds.
Assessing the photovoltaic technology landscape: efficiency and energy return on investment (EROI)
Authors: Zhou Z. , Carbajales-Dale M.
Published: January 2018

This paper compared different photovoltaic technologies by using the method in the plot.
Sex dependent effects of silver nanoparticles on the zebrafish gut microbiota
Authors: Ma Yanbo , Song Liyan , Lei Yu , Jia Panpan , Lu Chunjiao , Wu Jianfeng , Xi Chuanwu , Strauss Phyllis R. , Pei De-Sheng
Published: January 2018

Silver nanoparticles (AgNPs), the most prevalent commercial nanomaterial products, are widely released into the environment.
Emerging investigators series: a steric pore-flow model to predict the transport of small and uncharged solutes through a reverse osmosis membrane
Authors: Takeuchi Haruka , Tanaka Hiroaki , Nghiem Long D. , Fujioka Takahiro
Published: January 2018

This study proposed a new approach to apply the steric pore-flow model to predict the rejection of eight N-nitrosamines and seven VOCs that are of great concern in potable water reuse through an RO membrane.
An electrochemical oxidative homo-coupling reaction of imidazopyridine heterocycles to biheteroaryls
Authors: Gao Yongyuan , Wang Yang , Zhou Jie , Mei Haibo , Han Jianlin
Published: January 2018

An electrochemical homo-coupling reaction of imidazopyridine heterocycles has been developed for the synthesis of biheteroaryls. This reaction features good compatibility, high yields and excellent regioselectivities, which provides an efficient access to biheteroaryl compounds.
Rapid screening of gaseous catalysts in methane activation using ICP-QQQ-MS
Authors: He Qian , Wu Jiajia , Zhang Sichun , Fang Xiang , Xing Zhi , Wei Chao , Zhang Xinrong
Published: January 2018

A novel platform for rapid screening of gaseous catalysts in methane activation using ICP-QQQ-MS was developed.
Translation of protein charge and hydrophilicity to materials surface properties using thermal treatment in fluorous media
Authors: Wang Li-Sheng , Gopalakrishnan Sanjana , Lee Yi-Wei , Zhu Jiaxin , Nonnenmann Stephen S. , Rotello Vincent M.
Published: January 2018

Heat treatment in fluorous solvents generates stable films on 3D substrates, enabling translation of protein molecular properties into film characteristics.
The role of polyethylenimine in enhancing the efficiency of quantum dot light-emitting devices
Authors: Davidson-Hall Tyler , Aziz Hany
Published: January 2018

Polyethelenimine is found to improve QDLED efficiency with negligible effect on device stability despite increasing electron injection and poorer charge balance.
Achieving rapid Li-ion insertion kinetics in TiO2 mesoporous nanotube arrays for bifunctional high-rate energy storage smart windows
Authors: Tong Zhongqiu , Liu Shikun , Li Xingang , Mai Liqiang , Zhao Jiupeng , Li Yao
Published: January 2018

Smart electrochromic windows integrated with electrochemical energy storage capacity are receiving increasing interest for green buildings.
Crystallographic orientation of facets and planar defects in functional nanostructures elucidated by nano-focused coherent diffractive X-ray imaging
Authors: Richard Marie-Ingrid , Fernández Sara , Eymery Joël , Hofmann Jan Philipp , Gao Lu , Carnis Jérôme , Labat Stéphane , Favre-Nicolin Vincent , Hensen Emiel J. M. , Thomas Olivier , Schülli Tobias U. , Leake Steven J.
Published: January 2018

A novel approach based on nano-focused coherent Bragg X-ray imaging to characterise the crystallographic planes at the surface of single nanostructures and planar defects.
DFT coupled with NEGF study of a promising two-dimensional channel material: black phosphorene-type GaTeCl
Authors: Zhou Wenhan , Guo Shiying , Zhang Shengli , Zhu Zhen , Song Xiufeng , Niu Tianchao , Zhang Kan , Liu Xuhai , Zou Yousheng , Zeng Haibo
Published: January 2018

A stable three-dimensional layered GaTeCl bulk counterpart is first known from experiment since 1980s.
Passive membrane penetration by ZnO nanoparticles is driven by the interplay of electrostatic and phase boundary conditions
Authors: Tiwari Anuj , Prince Ashutosh , Arakha Manoranjan , Jha Suman , Saleem Mohammed
Published: January 2018

Nanoparticles prefer liquid disordered regions of the membrane during penetration driven by the phase boundary conditions.
Carbon nanotube aerogel–CoS2 hybrid catalytic counter electrodes for enhanced photovoltaic performance dye-sensitized solar cells
Authors: Liu Tao , Mai Xianmin , Chen Haijun , Ren Jing , Liu Zheting , Li Yingxiang , Gao Lina , Wang Ning , Zhang Jiaoxia , He Hongcai , Guo Zhanhu
Published: January 2018

Owing to the large number of catalytically active sites and sufficient connections between CoS2 and a CNA, a CNA–CoS2 CE exhibited a higher electrocatalytic activity, and faster ion diffusion and electron transfer than a CNA CE.
Design and preparation of a new polyurea–polysiloxane–polyether copolymer with a block soft segment prepared by utilizing aza-Michael addition reaction
Authors: Pang Bo , Zhang Jingzhe , Pang Minglei , Zhao Peijian , Yang Zhen , Feng Shengyu , Zhang Jie
Published: January 2018

A novel polyurea–polysiloxane–polyether copolymer has been prepared which displays mild microphase separation and high mechanical strength.
Synthesis, characterization and potential applications of 5-hydroxymethylfurfural derivative based poly(β-thioether esters) synthesized via thiol-Michael addition polymerization
Authors: Zhang Daihui , Dumont Marie-Josée
Published: January 2018

Dimethylphenylphosphine was used to efficiently initiate the thiol-Michael addition polymerization to yield 5-hydroxymethylfurfural (HMF) derivative based poly(β-thioether esters) with relatively high molecular weights (over 10 000 g mol−1) under mild conditions.
Ultrasensitive DNA detection based on target-triggered rolling circle amplification and fluorescent poly(thymine)-templated copper nanoparticles
Authors: Park Kwan Woo , Lee Chang Yeol , Batule Bhagwan S. , Park Ki Soo , Park Hyun Gyu
Published: January 2018

An ultrasensitive DNA detection method is developed based on target-triggered rolling circle amplification coupled with fluorescent poly(thymine)-templated copper nanoparticles.
Preparation of 3D hierarchical porous Co3O4 nanostructures with enhanced performance in lithium-ion batteries
Authors: Han Xiguang , Han Xiao , Zhan Wenwen , Li Rong , Wang Fan , Xie Zhaoxiong
Published: January 2018

Three-dimensional hierarchical Co3O4 microspheres assembled by well-aligned 1D porous nanorods were successfully fabricated. The sample exhibited excellent electrochemical properties as anode materials for LIBs.
Computational elucidation of the reaction mechanism for synthesis of pyrrolidinedione derivatives via Nef-type rearrangement – cyclization reaction
Authors: Ilieva Eleonora D. , Petrova Galina P. , Nikolova Rositca D. , Vayssilov Georgi N.
Published: January 2018

A quantum chemical study of all stages of pyrrolidinedione derivative synthesis from nitromethane and coumarin, which includes Michael addition, migration of an oxygen atom (Nef-type rearrangement), and cyclization to a pyrrolidine ring is reported.
Simultaneous removal of Sb(iii) and Cd(ii) in water by adsorption onto a MnFe2O4–biochar nanocomposite
Authors: Wang Yu-Ying , Ji Hai-Yang , Lu Hao-Hao , Liu Yu-Xue , Yang Rui-Qin , He Li-Li , Yang Sheng-Mao
Published: January 2018

In this study, a jacobsite–biochar nanocomposite (MnFe2O4–BC) was fabricated and used to simultaneously remove Sb(iii) and Cd(ii) from water via adsorption.
A solid-phase approach for the synthesis of α-aminoboronic acid peptides
Authors: Daniels Blake E. , Stivala Craig E.
Published: January 2018

A solid-phase synthesis of α-aminoboronic acid peptides using a 1-glycerol polystyrene resin is described.
One-step fabrication of tri-metallic PdCuAu nanothorn assemblies as an efficient catalyst for oxygen reduction reaction
Authors: Wang Hongjing , Yin Shuli , Li Yinghao , Yu Hongjie , Li Chunjie , Deng Kai , Xu You , Li Xiaonian , Xue Hairong , Wang Liang
Published: January 2018

A one-step method is proposed for the fabrication of PdCuAu nanothorn assemblies as an efficient catalyst for the oxygen reduction reaction.
In situ synthesis of CNTs@Ti3C2 hybrid structures by microwave irradiation for high-performance anodes in lithium ion batteries
Authors: Zheng W. , Zhang P. , Chen J. , Tian W. B. , Zhang Y. M. , Sun Z. M.
Published: January 2018

We have developed a facile route to the synthesis of CNTs@MXene hybrids with impressive electrochemical performance.
Porous CuO microsphere architectures as high-performance cathode materials for aluminum-ion batteries
Authors: Zhang Xuefeng , Zhang Guohua , Wang Shuai , Li Shijie , Jiao Shuqiang
Published: January 2018

Cathode materials with a porous structure are important in the development of aluminum-ion batteries (AIBs).
A general potentiodynamic approach for red phosphorus and sulfur nanodot incorporation on reduced graphene oxide sheets: metal-free and binder-free electrodes for supercapacitor and hydrogen evolution activities
Authors: Khalid Mohd. , Varela Hamilton
Published: January 2018

A simple potentiodynamic approach for red phosphorus and sulfur nanodot incorporation on reduced graphene oxide sheets.
Monolithic copper selenide submicron particulate film/copper foam anode catalyst for ultrasensitive electrochemical glucose sensing in human blood serum
Authors: Zhu Wenxin , Wang Jing , Zhang Wentao , Hu Na , Wang Jing , Huang Lunjie , Wang Rong , Suo Yourui , Wang Jianlong
Published: January 2018

A copper selenide submicron particulate film on Cu foam, synthesized by a facile hydrothermal process, shows superior glucose sensing performance.
Emerging perovskite materials for high density data storage and artificial synapses
Authors: Wang Yan , Lv Ziyu , Zhou Li , Chen Xiaoli , Chen Jinrui , Zhou Ye , Roy V. A. L. , Han Su-Ting
Published: January 2018

This review summarizes the recent progress in the development of perovskite materials for non-volatile memories and artificial synapses.
Correction: Nucleobases, nucleosides, and nucleotides: versatile biomolecules for generating functional nanomaterials
Authors: Pu Fang , Ren Jinsong , Qu Xiaogang
Published: January 2018

Correction for ‘Nucleobases, nucleosides, and nucleotides: versatile biomolecules for generating functional nanomaterials’ by Fang Pu et al., Chem. Soc. Rev., 2018, DOI: 10.1039/c7cs00673j.
Tailoring the energy band in flexible photodetector based on transferred ITO/Si heterojunction via interface engineering
Authors: Yao Guang , pan Taisong , Yan Zhuocheng , Liao Feiyi , Chen Sihong , Zhang Hulin , Gao Min , Lin Yuan
Published: January 2018

The interface barrier height of flexible ITO/silicon heterojunction can be tailored by imposing elastic uniaxial strain. The turn-on voltage and the response time of the photodetector based on the heterojunction also can be obviously reduced under uniaxial stretching strain.
Electrophilic fluorination of stereodefined disubstituted silyl ketene hemiaminals en route to tertiary α-fluorinated carbonyl derivatives
Authors: Huang Jian Qiang , Nairoukh Zackaria , Marek Ilan
Published: January 2018

A highly diastereoselective synthesis of tertiary α-fluoro carbonyl compounds is reported in only two chemical steps from a simple alkyne through the reaction of stereodefined fully substituted silyl ketene hemiaminal derivatives with Selectfluor.
Cation, magnetic, and charge ordering in MnFe3O5
Authors: Hong K. H. , Arevalo-Lopez A. M. , Coduri M. , McNally G. M. , Attfield J. P.
Published: January 2018

The high pressure material MnFe3O5 displays a rich variety of magnetically ordered states on cooling through three separate phase transitions.
Extracellular ATP activates store-operated Ca2+ entry in white adipocytes: functional evidence for STIM1 and ORAI1
Authors: El Hachmane Mickaël F. , Ermund Anna , Brännmark Cecilia , Olofsson Charlotta S.
Published: January 2018

In the present study, we have applied ratiometric measurements of intracellular Ca2+ concentrations ([Ca2+]i) to show that extracellularly applied ATP (adenosine triphosphate) (100 µM) stimulates store-operated Ca2+ entry (SOCE) in 3T3-L1 adipocytes. ATP produced a rapid increase in [Ca2+]i consisting of an initial transient elevation followed by a sustained elevated phase that could be observed only in the presence of extracellular Ca2+. Gene expression data and [Ca2+]i recordings with uridine-5′-triphosphate or with the phospholipase C (PLC) inhibitor U73122 demonstrated the involvement of purinergic P2Y2 receptors and the PLC/inositol trisphosphate pathway. The [Ca2+]i elevation produced by reintroduction of a Ca2+-containing intracellular solution to adipocytes exposed to ATP in the absence of Ca2+ was diminished by known SOCE antagonists. The chief molecular components of SOCE, the stromal interaction molecule 1 (STIM1) and the calcium release-activated calcium channel protein 1 (ORAI1), were detected at the mRNA and protein level. Moreover, SOCE was largely diminished in cells where STIM1 and/or ORAI1 had been silenced by small interfering (si)RNA. We conclude that extracellular ATP activates SOCE in white adipocytes, an effect predominantly mediated by STIM1 and ORAI1.
Mobilization of a splicing factor through a nuclear kinase–kinase complex
Authors: Aubol Brandon E. , Keshwani Malik M. , Fattet Laurent , Adams Joseph A.
Published: January 2018

The splicing of mRNA is dependent on serine-arginine (SR) proteins that are mobilized from membrane-free, nuclear speckles to the nucleoplasm by the Cdc2-like kinases (CLKs). This movement is critical for SR protein-dependent assembly of the macromolecular spliceosome. Although CLK1 facilitates such trafficking through the phosphorylation of serine-proline dipeptides in the prototype SR protein SRSF1, an unrelated enzyme known as SR protein kinase 1 (SRPK1) performs the same function but does not efficiently modify these dipeptides in SRSF1. We now show that the ability of SRPK1 to mobilize SRSF1 from speckles to the nucleoplasm is dependent on active CLK1. Diffusion from speckles is promoted by the formation of an SRPK1–CLK1 complex that facilitates dissociation of SRSF1 from CLK1 and enhances the phosphorylation of several serine-proline dipeptides in this SR protein. Down-regulation of either kinase blocks EGF-stimulated mobilization of nuclear SRSF1. These findings establish a signaling pathway that connects SRPKs to SR protein activation through the associated CLK family of kinases.
High output power 243 GHz voltage controlled oscillator in a 130 nm SiGe BiCMOS process
Authors: Zhou Peigen , Chen Jixin , Yan Pinpin , Hou Debin , Hong Wei
Published: January 2018

A four‐stage fundamental ring oscillator based on 130 nm SiGe HBT technology is reported. By utilising a novel ground wall decoupling structure as well as a step impedance conversion structure, the generated output power is optimised. The fundamental VCO has a measured peak output power of −1.4 dBm at 243 GHz. The output frequency could be tuned from 237.2 to 249.8 GHz with a tuning range of 5.18%. The core size of the oscillator is only 40 × 80 μm2. The peak DC‐to‐RF efficiency is 1.95% at a 0.94 V power supply. To the best of our knowledge, the proposed VCO achieves the highest output power compared with the other silicon‐based fundamental oscillators over 200 GHz.
Fast‐response full‐wave inductor current sensor for 10 MHz buck converter
Authors: Zhou Yong , Zheng Yanqi , Leung Ka Nang
Published: January 2018

A sense‐FET‐based inductor current sensor for a buck converter operating in 10 MHz switching frequency is reported in this Letter. The proposed sensor utilises an adaptive gm‐boosting amplifier to maintain stable current sensing loop gain and bandwidth over a wide range of load current. Moreover, a mirrored source‐degeneration output stage is introduced to further eliminate the bandwidth variation by loading change and achieves full‐wave current sensing with smooth transition between the sensed peak and valley currents as the inductor is energised and de‐energised. Simulation results show high sensing accuracy better than 96.8% with inductor current varying from 200 mA to 2 A. Furthermore, the settling time is <6 ns during the state transition between peak and valley current sensing with low‐voltage spikes.
MIMO visible light communication system with block Markov superposition transmission
Authors: Chen Shengxiao , Ma Xiao
Published: January 2018

This study is concerned with coded multiple‐input multiple‐output (MIMO) visible light communication (VLC) system, where unipolar M‐level pulse amplitude modulation is assumed along with MIMO transmission techniques, including repetition coding, spatial multiplexing and spatial modulation. In order to evaluate the performance of MIMO‐VLC system, the authors analyse the mutual information of the MIMO techniques, based on which the block Markov superposition transmission (BMST) codes are constructed to improve the bit‐error rate (BER) performance of the system. In addition, they present a genie‐aided lower bound to predict the performance of the BMST‐VLC system in the low‐BER region. Simulation results demonstrate that the proposed scheme can achieve significant coding gain compared with Reed‐Solomon‐coded MIMO‐VLC system adopted in IEEE standard 802.15.7.
Coordinated charging and discharging strategies for plug‐in electric bus fast charging station with energy storage system
Authors: Chen Huimiao , Hu Zechun , Zhang Hongcai , Luo Haocheng
Published: January 2018

Plug‐in electric bus (PEB) is an environmentally friendly mode of public transportation and PEB fast charging stations (PEBFCSs) play an essential role in the operation of PEBs. Under effective control, deploying an energy storage system (ESS) within a PEBFCS can reduce the peak charging loads and the electricity purchase costs. To deal with the (integrated) scheduling problem of (PEBs charging and) ESS charging and discharging, in this study, the authors propose an optimal real‐time coordinated charging and discharging strategy for a PEBFCS with ESS to achieve maximum economic benefits. According to whether the PEB charging loads are controllable, the corresponding mathematical models are, respectively, established under two scenarios, i.e. coordinated PEB charging scenario and uncoordinated PEB charging scenario. The price and lifespan of ESS, the capacity charge of PEBFCS and the electricity price arbitrage are considered in the models. Further, under the coordinated PEB charging scenario, a heuristics‐based method is developed to get the approximately optimal strategy with computation efficiency dramatically enhanced. Finally, the authors validate the effectiveness of the proposed strategies, interpret the effect of ESS prices on the usage of ESS and provide the sensitivity analysis of ESS capacity through the case studies.
Distributed load shedding for microgrid with compensation support via wireless network
Authors: Xu Qimin , Yang Bo , Chen Cailian , Lin Feilong , Guan Xinping
Published: January 2018

Due to the limited generation and finite inertia, microgrids suffer from a large frequency and voltage deviation which can lead to system collapse. Thus, a reliable load shedding method is required to maintain frequency stability. A wireless network, benefiting from the high flexibility and low deployment cost, is considered as a promising technology for fine‐grained management. In this study, a distributed load shedding solution via a wireless network is proposed for balancing the supply–demand and reducing the load‐shedding amount. Firstly, the real‐power coordination of different priority loads is formulated as an optimisation problem. To solve this problem, a distributed load shedding algorithm based on sub‐gradient method is developed for gradually shedding loads. Using this method, power compensation can be utilised and has more time to decrease the power deficit, consequently reducing the load‐shedding amount. Secondly, a multicast metropolis schedule based on time‐division multiple access is developed. In this protocol, time slots are dedicatedly allocated to increase the response rate. A checking and retransmission mechanism is utilised to enhance the reliability of our method. Finally, the proposed solution is evaluated by using an NS3‐Matlab co‐simulator. The numerical results demonstrate the feasibility and effectiveness of our solution.
Efficient method for classification of alcoholic and normal EEG signals using EMD
Authors: Priya Anchala , Yadav Pooja , Jain Shweta , Bajaj Varun
Published: January 2018

The electroencephalogram (EEG) signal is an electrical representation of brain's working that reflects various physiological and pathological activities such as alcoholism. Alcohol can affect whole parts of the body but, it particularly affects the brain, heart, liver, and the immune system; its effects on the brain are called brain disorders. Nowadays, automatic identification of alcoholic subjects based on EEG signals has become one of the challenging problems in biomedical research. In this study, an automatic classification method for classifying alcoholic and normal EEG signals, based on empirical mode decomposition (EMD), is proposed. The uniqueness of EMD method is to decompose non‐stationary and non‐linear signals into a set of stationary intrinsic mode functions (IMFs) that are band limited signals. These IMFs are transformed into analytic representations by applying the Hilbert transform. From these analytic IMFs, various features namely mean, kurtosis, skewness, entropy, and negentropy are extracted; these features are used as input to least squares support vector machines (LS‐SVMs) classifier with radial basis function (RBF) kernel and polynomial kernel. The accuracy results achieved for LS‐SVM classifier with polynomial and RBF kernels are found to be 96.67 and 97.92%, respectively, which are found to be better as compared with other state‐of‐the‐art methods.
ALMA observations of AGN fuelling
Authors: Maccagni F. M. , Morganti R. , Oosterloo T. A. , Oonk J. B. R. , Emonts B. H. C.
Published: January 2018

We present ALMA observations of the 12CO (2–1) line of the newly born (tradio ~ 102 years) active galactic nucleus (AGN), PKS B1718–649. These observations reveal that the carbon monoxide in the innermost 15 kpc of the galaxy is distributed in a complex warped disk. In the outer parts of this disk, the CO gas follows the rotation of the dust lane and of the stellar body of the galaxy hosting the radio source. In the innermost kiloparsec, the gas abruptly changes orientation and forms a circumnuclear disk (r ≲ 700 pc) with its major axis perpendicular to that of the outer disk. Against the compact radio emission of PKS B1718–649 (r ~ 2 pc), we detect an absorption line at red-shifted velocities with respect to the systemic velocity (Δv = +365 ± 22 km s−1). This absorbing CO gas could trace molecular clouds falling onto the central super-massive black hole. A comparison with the near-infrared H2 1-0 S(1) observations shows that the clouds must be close to the black hole (r ≲ 75 pc). The physical conditions of these clouds are different from the gas at larger radii, and are in good agreement with the predictions for the conditions of the gas when cold chaotic accretion triggers an active galactic nucleus. These observations on the centre of PKS B1718–649 provide one of the best indications that a population of cold clouds is falling towards a radio AGN, likely fuelling its activity.
Detection of X-ray flares from
AX J1714.1−3912,
the unidentified source near
RX J1713.7−3946
Authors: Miceli Marco , Bamba Aya
Published: January 2018

Context. Molecular clouds are predicted to emit nonthermal X-rays when they are close to particle-accelerating supernova remnants (SNRs), and the hard X-ray source AX J1714.1−3912, near the SNR RX J1713.7−3946, has long been considered a candidate for diffuse nonthermal emission associated with cosmic rays diffusing from the remnant to a closeby molecular cloud.

Aim. We aim at ascertaining the nature of this source by analyzing two dedicated X-ray observations performed with Suzaku and Chandra.

Methods. We extracted images from the data in various energy bands, spectra, and light curves and studied the long-term evolution of the X-ray emission on the basis of the ~4.5 yr time separation between the two observations.

Results. We found that there is no diffuse emission associated with AX J1714.1−3912, which is instead the point-like source CXOU J171343.9−391205. We discovered rapid time variability (timescale ~ 103 s), together with a high intrinsic absorption and a hard nonthermal spectrum (power law with photon index Γ ~ 1.4). We also found that the X-ray flux of the source drops down by 1–2 orders of magnitude on a timescale of a few years.

Conclusions. Our results suggest a possible association between AX J1714.1−3912 and a previously unknown supergiant fast X-ray transient, although further follow-up observations are necessary to prove this association definitively.
Performance measurement in data envelopment analysis without slacks: an application to electricity distribution companies
Authors: Pourhabib Azam , Kordrostami Sohrab , Amirteimoori Alireza , Matin Reza Kazemi
Published: January 2018

In performance measurement of the firms using tools such as data envelopment analysis (DEA) models, weak efficient units are almost appeared as reference points in the models. To avoid zero weights or equivalently non-zero slacks in DEA assessment, weights restrictions are used frequently. In DEA literature, two-stage procedures are developed to deal with non-zero slacks based on restricting input/output weights in multiplier formulating the CCR DEA model. In this paper, a single-stage approach for efficiency evaluation is developed to ensure zero slacks in target setting and avoid weights dissimilarity. A real case on electricity distribution companies in Iran has been given to demonstrate the applicability of the proposed approach.
Trimethylphosphine-Promoted Alcoholysis of α,β-Unsaturated Imides and α,β-Unsaturated Esters
Authors: Hosokawa Seijiro , Sato Haruka
Published: January 2018

α,β-Unsaturated imides and α,β-unsaturated esters were found to undergo alcoholysis in the presence of trimethylphosphine. The reaction is initiated by nucleophilic addition of trimethylphosphine to the double bond of the α,β-unsaturated carbonyl compound. Saturated imides also undergo the alcoholysis in the presence of the corresponding α,β-unsaturated imide.
Therapeutic Assessment of Vulvar Squamous Intraepithelial Lesions with CO2 Laser Vaporization in Immunosuppressed Patients
Authors: Ribalta Julisa Chamorro Lascasas , Mateussi Mariana Vendramin , Speck Neila Maria de Góis
Published: January 2018

Objective A vulvar squamous intraepithelial lesion is deemed to be a preceding lesion to vulvar cancer, especially in women aged under 40 years, holders of an acquired or idiopathic immunosuppression. Several treatments have been used to treat these lesions. One of the aesthetically acceptable therapeutic methods is the CO2 laser vaporization.

Methods In a transversal study, 46 records of immunosuppressed women bearing a vulvar low grade and/or high grade squamous intraepithelial lesion were selected out of the retrospective analysis, computing age, date of record, date of vulvar lesion treatment with CO2 laser, the time elapsed between the first and the last visit (in months), the number of visits, the presence or absence of condylomatous lesions in other female lower genital tract sites and whether or not recurrences and persistence of intraepithelial lesions have been noticed during the follow-up.

Results Patients bearing vulvar high-grade squamous intraepithelial lesion and immunosuppressed (serum positive for human immunodeficiency virus [HIV] or with solid organs transplantation) have shown a higher level of persistence of lesions and a higher chance of having other areas of the female lower genital tract involved.

Conclusion While the CO2 laser vaporization is the most conservative method for the treatment of vulvar high-grade intraepithelial lesions, it is far from being the ideal method, due to the intrinsic infection features considered. The possibility of persistence, recurrences and spontaneous limited regression indicates that a closer surveillance in the long-term treated cases should be considered, in special for immunosuppressed patients.
Developing Deep Learning Applications for Life Science and Pharma Industry
Authors: Siegismund Daniel , Tolkachev Vasily , Heyse Stephan , Sick Beate , Duerr Oliver , Steigele Stephan
Published: January 2018

Deep Learning has boosted artificial intelligence over the past 5 years and is seen now as one of the major technological innovation areas, predicted to replace lots of repetitive, but complex tasks of human labor within the next decade. It is also expected to be ‘game changing’ for research activities in pharma and life sciences, where large sets of similar yet complex data samples are systematically analyzed. Deep learning is currently conquering formerly expert domains especially in areas requiring perception, previously not amenable to standard machine learning. A typical example is the automated analysis of images which are typically produced en-masse in many domains, e. g., in high-content screening or digital pathology. Deep learning enables to create competitive applications in so-far defined core domains of ‘human intelligence’. Applications of artificial intelligence have been enabled in recent years by (i) the massive availability of data samples, collected in pharma driven drug programs (=‘big data’) as well as (ii) deep learning algorithmic advancements and (iii) increase in compute power. Such applications are based on software frameworks with specific strengths and weaknesses. Here, we introduce typical applications and underlying frameworks for deep learning with a set of practical criteria for developing production ready solutions in life science and pharma research. Based on our own experience in successfully developing deep learning applications we provide suggestions and a baseline for selecting the most suited frameworks for a future-proof and cost-effective development.
Verordnungspraxis und Risiken von Protonenpumpenblockern – Fiktion und Fakten
Authors: Koop Herbert
Published: January 2018

Derzeit werden ein nicht-indikationsgerechter Einsatz und potenzielle Risiken einer Therapie mit Protonenpumpeninhibitoren (PPI) intensiv diskutiert. Diese Übersichtsarbeit beleuchtet kritisch das Verschreibungsverhalten bzgl. PPI in Praxis und Klinik, zeigt Exit-Strategien aus einer langfristigen PPI-Behandlung auf und evaluiert kritisch das Risikoprofil von PPI.
In Vitro and In Situ Absorption and Metabolism of Sesquiterpenes from Petasites hybridus Extracts
Authors: Disch Lucia , Forsch Kristina , Siewert Beate , Drewe Jürgen , Fricker Gert
Published: January 2018

Petasites hybridus extract is used in the treatment of seasonal allergic rhinitis. The aim of this study was to evaluate the active constituent petasin and its isomers isopetasin and neopetasin (petasins) in the P. hybridus extract Ze 339 for liberation, dissolution, absorption, and metabolism. The determination of pH-dependent thermodynamic solubility was performed via the shake-flask method. Petasins exhibited a low solubility that was pH independent. In vivo, the concentration of solute drugs is decreased continuously by intestinal absorption. Therefore, low solubility is not assumed to be critical for in vivo performance. Additionally, dissolution of an herbal medicinal product containing P. hybridus extract Ze 339 was assessed. Furthermore, high permeability through Caco-2 monolayers was evident. Using an in situ rat model, absorption capacity for petasins was found in all tested intestinal segments, namely, duodenum, jejunum, and ileum. Besides, high metabolism was evident both in Caco-2 monolayers and in the rat intestine. To compare intestinal and hepatic metabolism of petasins, in vitro enzyme assays using liver and intestinal cytosol and microsomes (S9 fraction) of rats and humans were performed. A significantly higher metabolic rate was found in the liver S9 fraction of both species compared with the intestinal S9 fraction.
Transfer-free, lithography-free, and micrometer-precision patterning of CVD graphene on SiO2 toward all-carbon electronics
Authors: Dong Yibo , Xie Yiyang , Xu Chen , Li Xuejian , Deng Jun , Fan Xing , Pan Guanzhong , Wang Qiuhua , Xiong Fangzhu , Fu Yafei , Sun Jie
Published: January 2018

A method of producing large area continuous graphene directly on SiO2 by chemical vapor deposition is systematically developed. Cu thin film catalysts are sputtered onto the SiO2 and pre-patterned. During graphene deposition, high temperature induces evaporation and balling of the Cu, and the graphene “lands onto” SiO2. Due to the high heating and growth rate, continuous graphene is largely completed before the Cu evaporation and balling. 60 nm is identified as the optimal thickness of the Cu for a successful graphene growth and μm-large feature size in the graphene. An all-carbon device is demonstrated based on this technique.
Note: An innovative method for 12C4+ suppression in 18O6+ beam production in an electron cyclotron resonance ion source
Authors: Muto Hideshi , Ohshiro Yukimitsu , Kotaka Yasuteru , Yamaguchi Hidetoshi , Sakemi Yasuhiro , Kobayashi Kiyoshi , Nishimura Makoto , Oyaizu Michihiro , Kubono Shigeru , Kase Masayuki , Hattori Toshiyuki , Shimoura Susumu
Published: January 2018

It is a major and complex task to accelerate an ion which has the same charge to mass ratio with strong contaminant ions, such as 12C4+ in the 18O6+ beam. An innovative method has been developed to suppress the contaminant ions in the Electron Cyclotron Resonance (ECR) ion source by introducing Li vapor. The ion distribution inside the ECR zone was obtained by the optical analysis of ions inside the ECR ion source. The 12C4+ ions were suppressed as much as by a factor of 10, whereas the 18O6+ beam changed little with the use of this technique.
Experimental characterization of pairwise correlations from triple quantum correlated beams generated by cascaded four-wave mixing processes
Authors: Wang Wei , Cao Leiming , Lou Yanbo , Du Jinjian , Jing Jietai
Published: January 2018

We theoretically and experimentally characterize the performance of the pairwise correlations from triple quantum correlated beams based on the cascaded four-wave mixing (FWM) processes. The pairwise correlations between any two of the beams are theoretically calculated and experimentally measured. The experimental and theoretical results are in good agreement. We find that two of the three pairwise correlations can be in the quantum regime. The other pairwise correlation is always in the classical regime. In addition, we also measure the triple-beam correlation which is always in the quantum regime. Such unbalanced and controllable pairwise correlation structures may be taken as advantages in practical quantum communications, for example, hierarchical quantum secret sharing. Our results also open the way for the classification and application of quantum states generated from the cascaded FWM processes.
Sinc-interpolants in the energy plane for regular solution, Jost function, and its zeros of quantum scattering
Authors: Annaby M. H. , Asharabi R. M.
Published: January 2018

In a remarkable note of Chadan [Il Nuovo Cimento 39, 697–703 (1965)], the author expanded both the regular wave function and the Jost function of the quantum scattering problem using an interpolation theorem of Valiron [Bull. Sci. Math. 49, 181–192 (1925)]. These expansions have a very slow rate of convergence, and applying them to compute the zeros of the Jost function, which lead to the important bound states, gives poor convergence rates. It is our objective in this paper to introduce several efficient interpolation techniques to compute the regular wave solution as well as the Jost function and its zeros approximately. This work continues and improves the results of Chadan and other related studies remarkably. Several worked examples are given with illustrations and comparisons with existing methods.