bluuebunny/crossref_metadata_2025 huggingface dataset:
Utilization of Physiologically Based Pharmacokinetic Modeling in Pharmacokinetic Study of Natural Medicine: An Overview
Authors: Jia Qiuyu , He Qingfeng , Yao Li , Li Min , Lin Jiaying , Tang Zhijia , Zhu Xiao , Xiang Xiaoqiang
Published: December 2022

Natural medicine has been widely used for clinical treatment and health care in many countries and regions. Additionally, extracting active ingredients from traditional Chinese medicine and other natural plants, defining their chemical structure and pharmacological effects, and screening potential druggable candidates are also uprising directions in new drug research and development. Physiologically based pharmacokinetic (PBPK) modeling is a mathematical modeling technique that simulates the absorption, distribution, metabolism, and elimination of drugs in various tissues and organs in vivo based on physiological and anatomical characteristics and physicochemical properties. PBPK modeling in drug research and development has gradually been recognized by regulatory authorities in recent years, including the U.S. Food and Drug Administration. This review summarizes the general situation and shortcomings of the current research on the pharmacokinetics of natural medicine and introduces the concept and the advantages of the PBPK model in the study of pharmacokinetics of natural medicine. Finally, the pharmacokinetic studies of natural medicine using the PBPK models are summed up, followed by discussions on the applications of PBPK modeling to the enzyme-mediated pharmacokinetic changes, special populations, new drug research and development, and new indication adding for natural medicine. This paper aims to provide a novel strategy for the preclinical research and clinical use of natural medicine.
Distribution, Antioxidant Capacity, Bioavailability and Biological Properties of Anthocyanin Pigments in Blood Oranges and Other Citrus Species
Authors: Rapisarda Paolo , Amenta Margherita , Ballistreri Gabriele , Fabroni Simona , Timpanaro Nicolina
Published: December 2022

Anthocyanins are natural pigments that give a red, purple, and blue color to many plant, flower, fruit, and vegetable species. Their presence within the genus Citrus was first reported in 1916, and it is well-known that the red color of the flesh and rind of blood (red or pigmented) oranges (Citrus sinensis L. Osbeck) is due to the presence of anthocyanins. They are also present in the young shoots, flowers, and peel of lemon (Citrus limon (L.) Burm. f.), citron (Citrus medica L.), and other citrus species. Since then, the scientific community has expressed increasing interest in studying their profile and distribution, with many published studies focused on the quali-quantitative pattern in the different vegetative tissues belonging to the genus Citrus. Moreover, with the discovery of their relevant antioxidant activity, owing to their ability to capture free radicals, much research has been performed in the last two decades on their radical scavenging power, in vitro and in vivo biological properties, and anticarcinogenic capacity, also focusing attention on their bioavailability for humans. The present work is intended as a comprehensive review of the advances in scientific research on anthocyanin pigments naturally occurring within the genus Citrus, including their natural distribution, antioxidant capacity, bioavailability, and biological value and properties. The scientific evidence herein reported can be used to further increase the knowledge of this class of compounds and represents a valuable and comprehensive contribution to promoting anthocyanin-rich citrus fruit consumption as a healthy dietary habit.
Blackcurrant (Ribes nigrum L.) Seeds—A Valuable Byproduct for Further Processing
Authors: Wójciak Magdalena , Mazurek Barbara , Tyśkiewicz Katarzyna , Kondracka Małgorzata , Wójcicka Grażyna , Blicharski Tomasz , Sowa Ireneusz
Published: December 2022

The rational exploitation of byproducts is important from the point of view of their potential applicability in various fields. In this study, the possibility of further processing of blackcurrant seeds (BCs), which are a byproduct of fruit processing, was investigated. BCs were used as a material for the extraction of oil on a semi-industrial scale, and the residues were assessed in terms of their potential application in skin care products. Supercritical fluid extraction (SFE) using CO2 at pressures of 230 and 330 bar and extraction temperature of 40 °C was exploited for isolation of oil, and the products were characterised taking into account lipophilic constituents. After 120 min, the oil yields were 19.67% and 20.94% using CO2 at 230 and 330 bar, respectively, which showed that SFE was an effective method on a semi-industrial scale, taking into account the extraction yield. The oils had similar fatty acid compositions with a high percentage of linoleic acid (ca. 43%); however, tocopherols and carotenoids were most abundant in the oil obtained at 230 bar. It was also found that the composition of the SFE oils was comparable with that of cold-pressed oil, which shows that supercritical fluid extraction provides a high-quality product; therefore, it can be an alternative to cold pressing. Furthermore, the chemical compositions of the extracts from the oil isolation residues were established using UPLC-MS, and the impact of the extracts on human skin fibroblasts was assessed using the MTT and NR assays. The quantitative analysis revealed that the residues contained high amounts of polyphenolic acids, including gallic, protocatechuic, and hydroxybenzoic acid derivatives, as well as flavonoids, especially quercetin and kaempferol glucoside. Moreover, it was found that the extracts were nontoxic and exerted a stimulatory effect on cell metabolism. Therefore, they can be a valuable additive to natural plant-based cosmetics. Our results showed that blackcurrant seeds, regarded as a byproduct, can be a valuable material for further use.
Development of Monoclonal Antibody to Specifically Recognize VP0 but Not VP4 and VP2 of Foot-and-Mouth Disease Virus
Authors: Park Sun Young , Jin Jong Sook , Kim Dohyun , Kim Jae Young , Park Sang Hyun , Park Jong-Hyeon , Park Choi-Kyu , Ko Young-Joon
Published: December 2022

Foot-and-mouth disease (FMD) is a highly contagious vesicular disease that affects cloven-hoofed animals and often causes enormous economic loss in the livestock industry. The capsid of FMD virus (FMDV) consists of four structural proteins. Initially, one copy each of the proteins VP0, VP3, and VP1 are folded together into a protomer, and five copies of the protomer compose a pentamer. Finally, 12 pentamers are assembled into an icosahedral capsid. At the maturation stage during RNA encapsidation, VP0 is cleaved into VP4 and VP2. The mechanism underlying VP0 maturation remains unclear. While monoclonal antibodies (mAbs) against VP2 have been developed in previous studies, a mAb specific to VP0 has not yet been reported. In this study, we generated VP0-specific mAbs by immunizing mice with peptides spanning the C-terminal amino acids of VP4 and N-terminal amino acids of VP2. We verified that these mAbs displayed specificity to VP0 with no reactivity to VP4 or VP2. Therefore, these mAbs could prove useful in identifying the role of VP0 in FMDV replication and elucidating the mechanism underlying VP0 cleavage into VP4 and VP2.
Detecting Quantum Critical Points of Correlated Systems by Quantum Convolutional Neural Network Using Data from Variational Quantum Eigensolver
Authors: Wrobel Nathaniel , Baul Anshumitra , Tam Ka-Ming , Moreno Juana
Published: December 2022

Machine learning has been applied to a wide variety of models, from classical statistical mechanics to quantum strongly correlated systems, for classifying phase transitions. The recently proposed quantum convolutional neural network (QCNN) provides a new framework for using quantum circuits instead of classical neural networks as the backbone of classification methods. We present the results from training the QCNN by the wavefunctions of the variational quantum eigensolver for the one-dimensional transverse field Ising model (TFIM). We demonstrate that the QCNN identifies wavefunctions corresponding to the paramagnetic and ferromagnetic phases of the TFIM with reasonable accuracy. The QCNN can be trained to predict the corresponding ‘phase’ of wavefunctions around the putative quantum critical point even though it is trained by wavefunctions far away. The paper provides a basis for exploiting the QCNN to identify the quantum critical point.
The SSTeP-KiZ System—Secure Real-Time Communication Based on Open Web Standards for Multimodal Sensor-Assisted Tele-Psychotherapy
Authors: Primbs Jonas , Ilg Winfried , Thierfelder Annika , Severitt Björn , Hohnecker Carolin Sarah , Alt Annika Kristin , Pascher Anja , Wörz Ursula , Lautenbacher Heinrich , Hollmann Karsten , Barth Gottfried Maria , Renner Tobias , Menth Michael
Published: December 2022

In this manuscript, we describe the soft- and hardware architecture as well as the implementation of a modern Internet of Medical Things (IoMT) system for sensor-assisted telepsychotherapy. It enables telepsychotherapy sessions in which the patient exercises therapy-relevant behaviors in their home environment under the remote supervision of the therapist. Wearable sensor information (electrocardiogram (ECG), movement sensors, and eye tracking) is streamed in real time to the therapist to deliver objective information about specific behavior-triggering situations and the stress level of the patients. We describe the IT infrastructure of the system which uses open standards such as WebRTC and OpenID Connect (OIDC). We also describe the system’s security concept, its container-based deployment, and demonstrate performance analyses. The system is used in the ongoing study SSTeP-KiZ (smart sensor technology in telepsychotherapy for children and adolescents with obsessive-compulsive disorder) and shows sufficient technical performance.
Augmented Reality to Compensate for Navigation Inaccuracies
Authors: Bopp Miriam H. A. , Corr Felix , Saß Benjamin , Pojskic Mirza , Kemmling André , Nimsky Christopher
Published: December 2022

This study aims to report on the capability of microscope-based augmented reality (AR) to evaluate registration and navigation accuracy with extracranial and intracranial landmarks and to elaborate on its opportunities and obstacles in compensation for navigation inaccuracies. In a consecutive single surgeon series of 293 patients, automatic intraoperative computed tomography-based registration was performed delivering a high initial registration accuracy with a mean target registration error of 0.84 ± 0.36 mm. Navigation accuracy is evaluated by overlaying a maximum intensity projection or pre-segmented object outlines within the recent focal plane onto the in situ patient anatomy and compensated for by translational and/or rotational in-plane transformations. Using bony landmarks (85 cases), there was two cases where a mismatch was seen. Cortical vascular structures (242 cases) showed a mismatch in 43 cases and cortex representations (40 cases) revealed two inaccurate cases. In all cases, with detected misalignment, a successful spatial compensation was performed (mean correction: bone (6.27 ± 7.31 mm), vascular (3.00 ± 1.93 mm, 0.38° ± 1.06°), and cortex (5.31 ± 1.57 mm, 1.75° ± 2.47°)) increasing navigation accuracy. AR support allows for intermediate and straightforward monitoring of accuracy, enables compensation of spatial misalignments, and thereby provides additional safety by increasing overall accuracy.
Self-Powered Long-Life Microsystem for Vibration Sensing and Target Recognition
Authors: Yang Deng , Duan Wenrui , Xuan Guozhe , Hou Lulu , Zhang Zhen , Song Mingxue , Zhao Jiahao
Published: December 2022

Microsystems play an important role in the Internet of Things (IoT). In many unattended IoT applications, microsystems with small size, lightweight, and long life are urgently needed to achieve covert, large-scale, and long-term distribution for target detection and recognition. This paper presents for the first time a low-power, long-life microsystem that integrates self-power supply, event wake-up, continuous vibration sensing, and target recognition. The microsystem is mainly used for unattended long-term target perception and recognition. A composite energy source of solar energy and battery is designed to achieve self-powering. The microsystem’s sensing module, circuit module, signal processing module, and transceiver module are optimized to further realize the small size and low-power consumption. A low-computational recognition algorithm based on support vector machine learning is designed and ported into the microsystem. Taking the pedestrian, wheeled vehicle, and tracked vehicle as targets, the proposed microsystem of 15 cm3 and 35 g successfully realizes target recognitions both indoors and outdoors with an accuracy rate of over 84% and 65%, respectively. Self-powering of the microsystem is up to 22.7 mW under the midday sunlight, and 11 min self-powering can maintain 24 h operation of the microsystem in sleep mode.
Method of Changing Running Direction of Cheetah-Inspired Quadruped Robot
Authors: Ning Meng , Yang Jun , Zhang Ziqiang , Li Jun , Wang Zhi , Wei Longxing , Feng Pengjin
Published: December 2022

The rapid change of motion direction during running is beneficial to improving the movement flexibility of the quadruped robot, which is of great relevance to its research. How to make the robot change its motion direction during running and achieve good dynamic stability is a problem to be solved. In this paper, a method to change the running direction of the cheetah-inspired quadruped robot is proposed. Based on the analysis of the running of the cheetah, a dynamic model of the quadruped robot is established, and a two-level stability index system, including a minimum index system and a range index system, is proposed. On this basis, the objective function based on the stability index system and optimization variables, including leg landing points, trunk movement trajectory, and posture change rule, are determined. Through these constraints, the direction changes with good dynamic stability of the cheetah-inspired quadruped robot during running is realized by controlling the leg parameters. The robot will not roll over during high-speed movement. Finally, the correctness of the proposed method is proven by simulation. This paper provides a theoretical basis for the quadruped robot’s rapid change of direction in running.
A Local and Non-Local Features Based Feedback Network on Super-Resolution
Authors: Liu Yuhao , Chu Zhenzhong , Li Bin
Published: December 2022

Recent advances in Single Image Super-Resolution (SISR) achieved a powerful reconstruction performance. The CNN-based network (both sequential-based and feedback-based) performs well in local features, while the self-attention-based network performs well in non-local features. However, single block cannot always perform well due to the realistic images always with multiple kinds of features. In order to take full advantage of different blocks on different features. We have chosen three different blocks cooperating to extract different kinds of features. Addressing this problem, in this paper, we propose a new Local and non-local features-based feedback network for SR (LNFSR): (1) The traditional deep convolutional network block is used to extract the local non-feedbackable information directly and non-local non-feedbackable information (needs to cooperate with other blocks). (2) The dense skip-based feedback block is use to extract local feedbackable information. (3) The non-local self-attention block is used to extract non-local feedbackable information and the based LR feature information. We also introduced the feature up-fusion-delivery blocks to help the features be delivered to the right block at the end of each iteration. Experiments show our proposed LNFSR can extract different kinds of feature maps by different blocks and outperform other state-of-the-art algorithms.
Characterization of a Vision-Based Tool for the Investigation of Geometric Characteristics of Ground-Deposited Volcanic Ash
Authors: Andò Bruno , Baglio Salvatore , Castorina Salvatore , Campisi Alberto
Published: December 2022

With the support of public authorities and research institutions, volcanic ash fallout and its impact on the safety of people, infrastructure and services are addressed with the aim of defining protocols and instruments for the reliable and effective handling of related emergencies. Most of the solutions proposed in the literature on ash fallout monitoring suffer from high cost and are demanding in terms of installation and maintenance. The approach suggested in this work is based on the use of a low-cost vision embedded system and a dedicated algorithm which automatically processes acquired frames of ground-deposited volcanic ash in order to estimate the main geometric properties of each particle identified in the work area. A complete characterization of the system is presented, along with a robustness analysis of particle shapes, their orientation and their position in the inspected frame. An accuracy of ±40.2 µm (with a 3σ limit) and a resolution of 32.9 µm (in the worst case), over a framed area of 130 mm by 100 mm, were estimated; these values would fulfill the objectives of the application.
Challenges in Implementing Low-Latency Holographic-Type Communication Systems
Authors: Petkova Radostina , Poulkov Vladimir , Manolova Agata , Tonchev Krasimir
Published: December 2022

Holographic-type communication (HTC) permits new levels of engagement between remote users. It is anticipated that it will give a very immersive experience while enhancing the sense of spatial co-presence. In addition to the newly revealed advantages, however, stringent system requirements are imposed, such as multi-sensory and multi-dimensional data capture and reproduction, ultra-lightweight processing, ultra-low-latency transmission, realistic avatar embodiment conveying gestures and facial expressions, support for an arbitrary number of participants, etc. In this paper, we review the current limitations to the HTC system implementation and systemize the main challenges into a few major groups. Furthermore, we propose a conceptual framework for the realization of an HTC system that will guarantee the desired low-latency transmission, lightweight processing, and ease of scalability, all accompanied with a higher level of realism in human body appearance and dynamics.
Systematic Review of Mixed Studies on Malaria in Pregnancy: Individual, Cultural and Socioeconomic Determinants of Its Treatment and Prevention
Authors: Cardona-Arias Jaiberth Antonio
Published: December 2022

Malaria in pregnancy (MiP) is a global public health problem; its research is predominantly quantitative. The objective was to analyze the individual, cultural and socioeconomic determinants of the treatment and prevention of MiP with a systematic review of mixed studies (search had no date restriction). Reproducibility and evaluation of the methodological quality were guaranteed. 21 studies were included (20 from Africa). The quantitative component included 7816 pregnant women and 483 health workers. The qualitative component included 800 subjects (pregnant women, health workers, family members and community leaders). The main topics were the use and acceptability of WHO strategies to prevent MiP, individual determinants related with knowledge, perceptions, attitudes and behaviors on MiP, and cultural and socioeconomic barriers for its treatment and prevention. The main determinants of MiP were long distance to the clinic, lack of economic resources, low-coverage antenatal care, few health workers in the communities, drug shortages, cultural rules that prevent women’s participation in health issues, and misconceptions about MiP. MiP has determinants related to economic conditions, the structure and functioning of the health system, symbolic and cultural aspects, as well as knowledge, beliefs, perceptions and behavior of pregnant women, which prevent optimal access and use of preventive strategies. This study evidences the importance of intersectional, intersectoral, and interdisciplinary work to prevent MiP.
Femtosecond Laser-Assisted Cataract Surgery: Analysis of Surgical Phases and Comparison with Standard Phacoemulsification in Uncomplicated Cataracts
Authors: Baldascino Antonio , Carlà Matteo Mario , Giannuzzi Federico , Boselli Francesco , Caporossi Tomaso , Gambini Gloria , Villano Antonio , Caporossi Aldo , Rizzo Stanislao
Published: December 2022

The aim of this work is to compare the time of surgical phases and the cumulative dissipated energy (CDE) of the phacoemulsification phase in femtosecond laser-assisted cataract surgery (FLACS) and in standard surgical procedures of phacoemulsification (PCS). This prospective, non-randomized study analyzed the data of 100 cataract surgeries, 66 using FLACS and 34 with standard PCS. The time of surgical phases was recorded by a digital chronometer; an additional parameter recorded was the CDE of the phacoemulsification phase. The mean time of femtosecond laser phase was 121.7 ± 27.3 s with minimal fluctuations in duration; the mean opening time of the corneal tunnel and the service incisions was 60.5 ± 20.4 s in the PCS, and 48.8 ± 17.4 s in FLACS (p = 0.04); the mean time of capsulorhexis was 39.6 ± 12.9 s in the PCS and 7.0 ± 5.2 s in FLACS (p < 0.0001); the mean time of phacoemulsification was 180.1 ± 45.6 s in the PCS and 163.0 ± 38.2 s in FLACS (p = 0.12); the mean aspiration time of the residual cortical was 66.3 ± 27.5 s in the PCS and 91.5 ± 35.7 s in FLACS (p = 0.02). Overall, the total surgical time of the cataract surgery was 742.3 ± 185.8 s in PCS and 985.1 ± 118.6 s in FLACS (p = 0.03). The mean CDE was 11.35 in the PCS and 8.3 in FLACS (p = 0.01). In conclusion, the greatest advantage obtained from the use of the femtosecond laser was the reduction of the duration of the phacoemulsification time and of the CDE parameter.
Siberian sturgeon Acipenser baerii (Brandt, 1869) (Acipenseridae) of the Yenisei river. Part 1. Herd structure (overview)
Authors:   Krasnoyarsk State Agrarian University, Russia, Krasnoyarsk, Zadelenov V.A. ,   Krasnoyarsk branch of the All-Russian Research Institute of Fisheries and Oceanography (NIIERV), Russia, Krasnoyarsk, Chetvertakova E.V. ,   Krasnoyarsk State Agrarian University, Russia, Krasnoyarsk;, Alekseeva E.A. ,   Krasnoyarsk State Agrarian University, Russia, Krasnoyarsk, Zadelenova A.V. ,   Krasnoyarsk State Agrarian University, Russia, Krasnoyarsk
Published: December 2022

Siberian sturgeon is widely distributed in the river basin. Yenisei. Its range, the structure of the herd, including residential and semi-anadromous forms, and the scheme of migrations are described. The concept of population continuums is analyzed. Sturgeon is one of the largest fish on the river. Yenisei, reaches 124 kg of mass. It is shown that over 100 years of research, the linear and weight growth of the Yenisei sturgeon remains at the same level. Late sexual maturation of this species has been recorded: males become sexually mature at the age of 17–19 years, females mature at the age of 20–24 years. The intervals between successive spawnings in females are 5–6 years, males — 3–4. Absolute individual fecundity ranges from 50 to 750 thousand eggs. By the nature of the diet of sturgeon in the basin of the river. The Yenisei is a benthophage that consumes the larvae of chironomids, caddisflies, stoneflies, mayflies, midges, amphipods, and oligochaetes. Age and sex differences in nutrition are not observed. Information about the organization of sturgeon fishing on the river is given. Yenisei since the middle of the 19th century. The main share of the prey of this species fell on the lower reaches of the river; the catch of the spawning part of the population during the spawning migration brought about 10% of the total prey. It is noted that large-scale anthropogenic impacts have significantly changed the habitat of this species. The number and stocks of the Siberian sturgeon in the basin of the river. The Yenisei was noticeably reduced by the beginning of the 21st century.
Interannual variability of the functional state of bream (Abramis brama, L.) of the delta Volga in the pre-spawning period
Authors:   Astrakhan State University named after V.N. Tatishchev, Russia, Astrakhan, Fajzulina D.R. , Geraskin P.P. ,   Astrakhan State Technical University, Russia, Astrakhan, Kon’kova A.V. ,   Astrakhan State University named after V.N. Tatishchev, Russia, Astrakhan, Shirina Ju.M. ,   Astrakhan State University named after V.N. Tatishchev, Russia, Astrakhan
Published: December 2022

Bream is an important fishing object of the Volga-Caspian region. Its catches here in the middle of the last century reached 60 thousand tons, while currently they do not exceed 14 thousand tons. The study of the functional state of bream in the pre-spawning period makes it possible to determine the success of spawning, predict the survival of offspring at the early stages of ontogenesis. During the spawning periods (2007–2017 and 2021), the functional state of female and male bream caught in the waters of the delta Volga was studied. To assess the physiological state, the following biochemical parameters of blood were analyzed: the amount of hemoglobin, total serum protein, β-lipoproteins, cholesterol, total lipids, triglycerides, inorganic phosphorus, glucose, activity of alkaline phosphatase and aspartate aminotransferase, generally accepted methods of hematological and biochemical studies of blood and blood serum were used. The work used generally accepted methods of hematological and biochemical studies of blood and blood serum. As a result, there were statistically significant differences in the values of such indicators as the level of hemoglobin in the blood, cholesterol and β-lipoproteins cholesterol, glucose between females and males were noted. Significant interannual differences in the values of the studied indicators were revealed. The flow regime and the volume of spring flood had a decisive influence on the functional state of bream in the prespawning period. Deviations from the values of these indicators from the limits of reference values characteristic of fish and bream, in particular, taken from literary sources, were usually observed in low-water years (hemoglobin, β-lipoproteins, total lipids). The average level of correlation (r = 0.50) between the value of total whey protein and cholesterol was established in bream, which indicates a close relationship between protein and lipid metabolism. Thus, the physiological state of the Lower Volga bream in the pre-spawning period of high-water years can be characterized as relatively favorable.
Comment et pourquoi les vétérinaires ont-ils permis à Louis Pasteur de devenir « un bienfaiteur de l’humanité », le rôle essentiel joué par Henri Bouley
Authors: Rosolen Serge Georges
Published: December 2022

La sainte alliance que Pasteur a scellé avec la profession vétérinaire a joué un rôle déterminant au moment où celui-ci s’intéresse aux maladies animales. Les maladies affectant les troupeaux provoquent des pertes économiques importantes et dans les villes, la rage fait peur à juste titre. Depuis la création des Écoles vétérinaires par Bourgelat, le niveau des connaissances scientifiques s’est considérablement amélioré. Parallèlement des associations et des sociétés savantes vétérinaires voient le jour et publient leurs débats dans des bulletins. Les premiers périodiques vétérinaires diffusent, sous la direction des enseignants des Écoles, l’état de la science «qui se fait » . En retour, un abondant courrier des lecteurs questionne les rédactions et fait remonter des expériences de terrain. Pasteur lit ces communications «qui [ dit-il] lui mettent la tête en feu » . Un vétérinaire en particulier constitue un véritable réseau de compétences et d’expertises : Henri Bouley. Issu d’une famille de vétérinaires il a une expérience de praticien, c’est aussi un enseignant et il est Inspecteur Général des Écoles Vétérinaires. Il est aussi secrétaire général d’une société savante regroupant l’élite de la profession, la Société Centrale de Médecine Vétérinaire (SCMV) et rédacteur en chef du principal périodique de l’époque : le Recueil de Médecine

Vétérinaire (RMV). Converti aux théories de Pasteur en 1877, il rassemble autour de lui une profession qui accède à cette époque à une véritable notoriété scientifique et à une nouvelle légitimité : la société est en forte demande de médicalisation et la salubrité devient une valeur républicaine. Bouley a compris que, grâce à Pasteur, les vétérinaires deviennent de véritables agents sanitaires impliqués dans le contrôle de la contagion animale et aussi humaine. De son côté, Pasteur, chimiste de formation, comprend qu’un nouveau champ d’études s’ouvre à lui grâce aux vétérinaires : les maladies zoonotiques.
Analisis Implementasi Kompetensi Profesional Guru Pak Di Era Revolusi Industri 4.0 Dalam Meningkatkan Motivasi Belajar Siswa Di SMP Negeri SATAP 3 Sangalla’
Authors: Darius Trisnawadi
Published: December 2022

Abstract- This research is motivated by the problems that occur in Junior High School of SATAP 3 Sangalla', teachers especially Christian Religious Education do not yet have creativity in terms of making media and using technology in learning Christian Religious Education which motivates students so that the level of learning motivation of students is still very low. minimal. Therefore, the purpose of this study is to analyze the professional competence of Christian Religious Education teachers in the era of the industrial revolution 4.0 in increasing students' learning motivation at Junior High School of SATAP 3 Sangalla'. To get the results of the research objectives used descriptive qualitative methods with data collection techniques through literature study, observation, and interviews. The results of this study indicate that the professional competence of Christian Religious Education teachers in the era of the industrial revolution 4.0 in increasing student learning motivation at Junior High School of SATAP 3 Sangalla' is still very much needed by involving technology in the process of teaching, educating, training, assisting, directing and assessing students. The presence of Christian Religious Education teachers at Junior High School of SATAP 3 Sangalla' in the learning process still does not involve the use of technology so that it triggers a lack of student motivation. Therefore, teacher of Christian Religious Education must improve their professional competence in the 4.0 era by honing their ability to use technology to support classroom teaching because it can increase student learning motivation.
 Keywords:; Christian Religious Education Teacher, Industrial Revolution 4.0, Motivation, Professional Competence, Study.   
Kata kunci: Belajar, Guru PAK, Kompetensi Profesional, Motivasi, Revolusi Industri 4.0.
ANALYSIS OF BANKING EFFICIENCY USING THE DEA (DATA ENVELOPMENT ANALYSIS) METHOD AT MESTIKA BANK WHICH IS LISTED ON THE INDONESIA STOCK EXCHANGE
Authors: Jessica Cindy , Goh Thomas Sumarsan , Elidawati Elidawati
Published: December 2022

Bank Mestika is a private city bank domiciled in the city of Medan. Initially, Bank Mestika's efficiency performance evaluation was measured using financial ratios, but according to some experts the efficiency assessment could not be done partially but had to take into account all existing outputs and inputs. The purpose of the study was to find out how the level of efficiency of Bank Mestika is based on the size of the bank as seen from total assets using the Data Envelopment Analysis (DEA) approach. In this study, the object of research is banking efficiency, which is assessed by the size of the bank measured by total assets, BOPO is measured from interest income, interest expense, while ROA is measured from profit before tax with total assets. The Data Envelopment Analysis (DEA) method is used to measure banking efficiency in 2020 at Bank Mestika which is listed on the Indonesia Stock Exchange. The results show that Bank Mestika Dharma, Tbk is also facing inefficiency, meaning that the economic activity unit has not been able to allocate its resources optimally. The DEA approach can see the source of inefficiency by measuring the potential improvement of each input.
ASPECTS OF PEOPLE AND CULTURE IN INDUSTRIAL TRANSFORMATION 4.0 IN BANKING INDUSTRY
Authors: Sihombing Margaret , Riyanto Setyo
Published: December 2022

The purpose of this study is to analyze aspects of people and culture in the transformation of industry 4.0 in the banking industry. This research method is qualitatively descriptive with engineering design this study uses a literature approach and literature review. The transformation of Industry 4.0 in the banking industry is carried out on the Aspects of People and Culture as one of the main things. The people and culture aspects are important aspects and have the biggest point of 30% of the 5 pilar in INDI 4.0, which is an indication of the readiness of the industry to transform towards Industry 4.0. As for 3 the areas that are the focus of the Aspects of People and Culture are the Work Culture of Employees, Openness to Change, and the Development of Self Competence. With digital transformation, mindset owned by HR it can compete in the digital age and this will support banking to survive and develop into a company that excels in Industry 4.0.
EFFECT OF INTERPERSONAL COMUNICATION, REWARD, AND PUNISHMENT ON PERFORMANCE OF EMPLOYEES
Authors: Fatmasari Fatmasari , Nurdiana Nurdiana
Published: December 2022

This study aims to analyze (1) the influence of interpersonal communication on the performance of millennial employees, (2) the effect of rewards on the performance of millennial employees, (3) the effect of punishment on the performance of millennial employees, and (4) the influence of interpersonal communication, reward, and punishment on the performance of millennial employees. The research was conducted at the BPRS Niaga Madani Office for 2 (two) months, from March to April 2022. The population used in this study were all 32 millennial employees of the BPRS Niaga Madani Office. Due to the relatively small number of samples (less than 100 people) and easily accessible by researchers, a saturated sample was determined. The results of the study conclude that (1) interpersonal communication has no significant effect on the performance of millennial employees, (2) rewards have no significant effect on the performance of millennial employees, (3) punishment has a positive and significant effect on the performance of millennial employees, and (4) interpersonal communication, reward, and punishment have an effect on positive and significant impact on the performance of the millennial employees of the BPRS Niaga Madani Office.
Analisis Pertumbuhan Perusahaan, Kebijakan Hutang dan Ukuran Perusahaan terhadap Profitabilitas
Authors: Mursalini Wahyu Indah , Afniyeni Afniyeni , Yuliza Mai , Almasdi Almasdi , Putri Laras Restiana
Published: December 2022

This study aims to analyze company growth, debt policy and company size on profitability (a case study on investment companies listed on the Indonesian stock exchange in 2016-2020). The sample in this research is 7 companies with purposive sampling method in 2016-2020. Based on the results of statistical analysis, it can be concluded that the t-count is 3.553 and t-table is 2.040 and the significant value is 0.001 < 0.05. Then it can be formulated in accordance with the results of the study so that H₁ is accepted while Ho is rejected. It can be concluded that the company's growth has a significant effect on profitability (ROA) because t is greater than t table and the significant value is small from 0.05. Based on the results of statistics, it can be concluded that the tcount value is 1.151 and ttable 2.040 and the significant value is 0.259 < 0.05. Then it can be formulated in accordance with the results of the study so that H2 is rejected while Ho is accepted. So it can be concluded that debt policy has no significant effect on Profitability (ROA) because t is small from t table and significant value is greater than 0.05. Based on the results of statistics, it can be concluded that the tcount value is 3.540 and ttable 2.040 and the significant value is 0.001 < 0.05. Then it can be formulated in accordance with the results of the study so that H3 is accepted while Ho is rejected.
PENGARUH KOMPENSASI DAN PELATIHAN TERHADAP KINERJA KARYAWAN PT. TAJIRA KARYA PERSADA
Authors: Rosariani Intan Angela , Safrianto Arief Syah
Published: December 2022

The purpose to determine the effect of compensation and training on employee performance PT. Tajira Karya Persada. This research is included in the category of causal associative research using a quantitative approach. The research was conducted by distributing questionnaires all of whom were employees of PT. Tajira Karya Persada. The research method using partially and simultaneous linear regression analysis. The hypothesis states that both compensation and training have a positive and significant effect on employee performance of PT. Tajira Karya Persada.
PENGARUH KUALITAS PRODUK DAN KUALITAS LAYANAN TERHADAP MINAT BELI KONSUMEN PT HIJRAH INSAN KARIMA BEKASI
Authors: Ramadhan Hafizh Igo , Saputra Arry Dwi
Published: December 2022

The purpose to determine the effect of product quality and service quality on consumer buying interest PT. Hijrah Insan Karima Bekasi. The research method uses descriptive qualitative and quantitative analysis, the analytical model used is linear regression, both multiple and simple. The population in this study are consumers at PT. Hijrah Insan Karima Bekasi. The sampling technique of this study used simple random sampling. The sample as the object of research is respondents PT. Hijrah Insan Karima taken by chance. The result of Product quality and service quality have a positive and significant effect on consumer buying interest in PT. Hijrah Insan Karima Bekasi both simultaneous and partially.
Pengaruh Jenis Pupuk Organik terhadap Pertumbuhan Bibit Tanaman Jahe Merah (Zingiber officinale Rosc.)
Authors: Hasfiah Hasfiah , Apriani Nadia
Published: December 2022

Tujuan dari penelitian adalah untuk mengetahui pengaruh jenis pupuk organik terhadap pertumbuhan bibit tanaman jahe merah. Penelitian ini akan dilaksanakan pada bulan Mei sampai bulan Agustus 2022, yang berlokasi di kebun percobaan Program Studi Agoteknologi, Kelurahan Ngkari-ngkari, Kecamatan Bungi Kota Baubau. Rancangan percobaan yang digunakan dalam penelitian ini adalah Rancangan Acak Lengkap (RAL) dengan 3 ulangan yang terdiri atas : PO0 = Tanah (kontrol), PO1 = Tanah + Pupuk kandang sapi 150 g, PO2 = Tanah + Pupuk kandang kambing 150 g, PO3 = Tanah + Pupuk kandang ayam 150 g, PO4 = Tanah + Pupuk kandang babi 150 g. Data hasil pengamatan dari perlakuan diolah secara statistik. Jika hasil analisis berpengaruh nyata maka dilakukan uji lanjut dengan BNJ taraf 5%. Parameter yang diamati yaitu umur muncul tunas (hari), tinggi tanaman (cm), jumlah daun (helai), dan diameter batang (cm). Hasil penelitian menunjukan bahwa pemberian jenis pupuk organik berpengaruh terhadap parameter pertumbuhan tinggi tanaman, jumlah daun dan diameter batang bibit jahe merah. Perlakuan terbaik diperoleh pada PO1 ( tanah + 150 g pupuk kandang sapi ).
Kontribusi Daging Ayam Buras dan Faktor yang Mempengaruhi Keputusan Pembelian di Rumah Makan “Bebek Gazebo” Makassar
Authors: Nurlaelah Siti , Rahmaniar Yulia , Nirmayanti Della , Ahmad Asrul
Published: December 2022

Ayam buras menduduki tempat tersendiri dimasyarakat karena ayam buras memiliki cita rasa yang berbeda sehingga banyak rumah makan menyediakan menu ayam buras walaupun dengan harga yang relatif lebih tinggi. Tujuan penelitian ialah 1)  Menganalisis kontribusi ayam buras terhadap keseluruhan konsumsi ayam di rumah makan Bebek Gazebo, dan 2) Menganalisis faktor-faktor yang mempengaruhi konsumen memilih mengkonsumsi ayam buras di rumah makan Bebek Gazebo. Sebanyak 100 orang responden pada penelitian ini. Analisis data yang digunakan untuk penelitian ini ialah regresi linier berganda. Kontribusi ayam buras relatif lebih rendah dibandingkan dengan ayam broiler dan bebek yang merupakan menu utama di rumah makan tersebut. Hasil pengujian anova menyatakan Fhitung 4.641 > Ftabel 2.47 atas sig 0.000 < α0.05, sehingga Ho ditolak dan Ha diterima, bermakna  X1 (Kualitas Produk), X2 (Harga), X3 (Promosi), X4 (Tempat), berpengaruh secara signifikan terhadap keputusan pembelian (Y) pada taraf α0.05. Dapat disimpulkan bahwa faktor-faktor yang mempengaruhi keputusan pembelian dalam hal ini kualitas produk, harga, promosi dan tempat berpengaruh secara signifikan terhadap keputusan pembelian.
Analisis Produksi Padi Merah Kawondu Sebagai Pangan Lokal Masyarakat Wilayah Bekas Kesultanan Buton di Kelurahan Bugi Kecamatan Sorawolio Kota Baubau
Authors: Aliyaman Aliyaman , Asriyani Asriyani , Sandi Ali , Yanti Wulan Riski
Published: December 2022

Penelitian ini bertujuan untuk menganalisis produksi dan faktor-faktor pembatas yang berpengaruh terhadap rendahnya produksi padi merah Kawondudi Kelurahan Bugi Kecamatan sorawolio Kota Baubau. Penelitian dilakukan dengan menggunakan metode survei. Sampel penelitian adalah petani padi merah kawondu berjumlah 44 responden yang diambil menggunakan rumus Slovin dengan margin eror 5%. Penelitian dilakukan untuk mendapatkan data primer dan data sekunder. Variabel pengamatan dalam penelitian ini meliputi data karakteristik petani, produksi, tenaga kerja, luas lahan dan penggunaan teknologi. Data penelitian kemudian dianalisis secara kualitatif dan kuantitatif. Hasil penelitian menunjukkan bahwa rata-rata produksi padi merah Kawondu di Kelurahan Bugi Kecamatan Sorawolio Kota Baubau dengan luas lahan 20,75 hektar yaitu sebesar 43.950 kg dengan tingkat produktivitas 2.118 kg/hektar. Faktor produksi yang berpengaruh nyata terhadap produksi padi merah Kawondu di Kelurahan Bugi Kecamatan Sorawolio Kota Baubau yaitu luas lahan dan jumlah HOK, sedangkan faktor produksi yang tidak berpengaruh nyata yaitu jumlah pupuk urea dan NPK, jumlah pestisida cair dan padan dan jumlah benih.
PENGARUH SISTEM INFORMASI AKUNTANSI MANAJEMEN, PERILAKU INOVATIF DAN PARTISIPASI ANGGARAN TERHADAP KINERJA MANAJERIAL
Authors: Vincent Reynaldo , Panjaitan Delfi , Lesmana Desy
Published: December 2022

Penelitian ini bertujuan untuk menguji pengaruh sistem informasi akuntansi manajemen, perilaku inovatif dan partisipasi anggaran terhadap kinerja manajerial pada perusahaan hotel di Kota Palembang. Teori yang digunakan dalam penelitian ini adalah Goals Setting Theory. Populasi dalam penelitian ini adalah seluruh Hotel Kategori bintang 3 hingga bintang 5 sebanyak 27 yang terdaftar di Badan Pengelolaan Pajak Daerah (BPPD) Kota Palembang. Penentuan sampel dalam penelitian ini menggunakan metode kombinasi non probability dan probabilty yaitu purposive random sampling, sehingga didapatkan sebanyak 49 manager hotel di Kota Palembang. Teknik analisis data yang digunakan adalah analisis regresi linear berganda. Hasil penelitian menunjukkan bahwa secara keseluruhan variabel sistem informasi akuntansi manajemen dan partisipasi anggaran berpengaruh terhadap kinerja manajerial, sedangkan perilaku inovatif tidak berpengaruh
The Impact of Online Learning In The Internal Medicine Rotation Among Medical Clerks During The Covid 19 Pandemic and Lockdown
Authors: Marcial Melvin Remulla
Published: December 2022

Background: The impact of online learning during internal medicine rotation among graduating medical students was evaluated during COVID 19 pandemic. Objectives: The study aimed to gauge acceptability of a self-directed learning, recognize frustrations, identify coping mechanisms, assess rate of learning, evaluate study habits and appraise level of readiness in handling actual patients later in practice among graduating medical clerks. Methodology: An ambispective cohort design study involving both retrospective and prospective follow-up of respondents. The retrospective component involved blended learners with clinical experience (Group 1). The prospective component included online learner with clinical experience (Group 2) and online learner without clinical experience. Results: Group 1 showed that they favor pure traditional learning over pure online learning in contrast to the other 2 groups which rated acceptability of online learning high. All groups had high levels of frustration with their inability to experience actual patient exposure, had moderate to high level of coping mechanisms, and rated high the traditional learning and blended learning methodologies. In contrary, all groups rated low to moderate contributions of online learning to their learning. Group 3 had a significantly higher mean overall readiness score compared to the two other groups. Conclusion: The study showed the different levels of impact of online learning to the different population of medical clerks in terms of its acceptability as an alternative way of learning. Actual patient exposure is of main concern while different coping mechanisms maximize knowledge acquisition. Key words: Online learning, self directed, COVID 19 pandemic, Medical clerks
TWO THUMBS UP! A Review of the “PULMOSERYE: Pulmonary Patient Miniseries… Dead or Alive: The Saga of Mang Jose”- a Clerkship Learning Activity During the Pandemic
Authors: Rosales-Natividad Maria Piedad
Published: December 2022

The World Health Organization declared Covid 19 a pandemic in March 2020, disrupting medical education and creating a significant void in the hospital rotation of the clinical clerks. Alternative methods of teaching and learning had to be instituted, and since face-to-face encounters were still not allowed, all these activities had to be online. While the various activities were able to challenge critical analysis and thinking, the Section on Pulmonary Medicine felt that the clerks would benefit most from activities that would most closely simulate an actual patient encounter. And so, the PulmoSerye was born: a miniseries that followed the patient from initial consultation in the emergency room resulting in admission, events that happened in the ward, formulation of the Master Problem List, progress notes, giving discharge orders, writing the discharge summary, and finally a follow up via Telemedicine. This is what the clerks would have experienced if they had been in hospital. Activities such as the Pulmoserye should be highly considered as a viable option should clerkship hospital rotations once again be put on hold. Key words: Covid 19, online learning, medical education, innovation, clinical clerkship
Educação tecnológica ao alcance de todas? A invisibilidade das mulheres empobrecidas nas revistas produzidas por instituições federais do sul do Brasil
Authors: Silva Model Eliandra , Eggert Edla
Published: December 2022

Esse artigo apresenta resultados de um estudo que analisou a presença – ou não – da educação tecnológica direcionada para mulheres empobrecidas e estudantes do PROEJA em artigos publicados nas revistas de dois Institutos Federais: a revista #Tear, do IFRS, e a revista EJA em Debate, do IFSC. O recorte temporal das edições foram os anos de 2012 a 2017. Para a realização da análise dos artigos selecionados, utilizou-se a análise documental, por meio da perspectiva da hermenêutica feminista e da educação popular. Concluímos que nas revistas há uma invisibilização das mulheres estudantes no PROEJA, que sinaliza um reflexo de como a educação tecnológica, que já inclui as mulheres, ainda tem um grande desafio de perspectivar a presença delas nos Institutos Federais e na sociedade em geral.
Palavras-chave: Invisibilização. Mulheres do PROEJA. Educação Tecnológica.