bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS PENGELOMPOKAN DATA BERDASARKAN LAPORAN RL 4A PASIEN RAWAT INAP DI RSUD M. NATSIR SOLOK PERIODE 01 MARET – 31 MARET 2018
Authors: Kamal Syamsul , Lukita Nindi , Yastori Yastori
Published: March 2024

Hospital reporting is an organizational tool that aims to be able to produce information quickly, precisely and accurately to hospital management or those who need information. In the process of making the RL 4a report at the Mohammad Natsir Solok Regional Hospital, there were still obstacles. One of the obstacles in processing RL 4a reporting is that inpatient medical record files are not completely filled in and are still being worked on manually. Data collection was carried out at RSUD Mohammad Natsir Solok by recording data on inpatients who returned home from March 1 to March 31, 2018 with a total of 259 patients. The data was processed using a computer using the Microsoft Excel application program. The grouping of reports is based on RL 4a, where after processing the data, it is found that the most age group is the age group 45 to 64 years 54 women and 32 men, followed by the age group 24 to 44 years, where 38 women and 25 men -Male. For the sexes of patients the most were female as many as 158 and male 101 people, then for the disposition 249 were alive and 10 patients died.
Korelasi Nilai Bed Occupancy Rate dengan Jumlah Kunjungan Pasien di RSUD Lubuk Basung
Authors: Anala Melati , Yastori Yastori , Kamal Syamsul
Published: March 2024

Bed Occupancy Rate (BOR) data can be used to determine the level of service, to know the quality of hospital.The purpose of this paper is to determine the correlation or drill value with number patient visits at Lubuk Basung Hospital for the January-Februay 2017 periode.The data processed is secondary data of inpatients at Lubuk Basung Hospital for the January-February 2017 period, data obtained for 300 patients with a total of 109 beds, then data processing is carried out using the Microsoft Exel application program and utilizing the Pivot Table feature.Statistical processing was analyzed and presented in the form of tables and graphs by Barber Johnson.The results of data processing obtained a BOR of 28.80%, not efficient because the BOR is 60-85% efficient.BTR is 33 times, not efficient because BTR is 40-50 times a year.TI is 8 days, inefficient because it is 1-3 days efficient and ALOS is 4 days, inefficient because it is 6-9 days efficient. Based on the RL4a report,the highest age group was the 45-64 year age group with 78 patients, the highest gender grouping was male 153 patients and female 147 patients.Based on the living disposition of 295 patients, 5 patients died.The distribution of patients by region was mostly in Agam with 259 patients. The highest diagnosis was Pneumonia, Unspecified with a code of J18.9 with 27 diagnoses.The main diagnosis grouping based on defecation in ICD-10, the highest diagnosis was Chapter I, namely Certain Infectious and Parasite Disease with 20.67% totaling 62 diagnoses. There is a positive correlation between the number of patient visits and the number of bed usage.
Analisis Kasus-Kasus Kodifikasi Diagnosis Dan Tindakan Medis Di RSUD Pariaman Berdasarkan ICD-10 Dan ICD-9-CM
Authors: Ganesha Ramadona
Published: March 2024

Diagnosis codes and medical procedures need to be given accurately. An accurate code will have an impact on the accuracy of the code grouping report and is related to financing. This research was conducted at Pariaman Hospital to determine the grouping of diagnosis codes and medical procedures based on ICD-10 and ICD-9-CM. Data taken from Pariaman Hospital for the period 01 April – 30 April 2019, namely the number of discharged patients was 649 patients for a total of 30 days and the number of beds was 163. The research method is direct observation of medical record documents. The results obtained were that the highest diagnosis and code based on ICD-10 was a diagnosis of pneumonia with code J18.9 in 32 patients. The highest distribution of patient diagnoses based on bowel movements was BAB XV (Pregnancy, Childbirth and Puerperium) at 21.27% with 140 patients. The most common procedure performed was SC (Sectio Caesarea) with procedure code 74.99 for 8 patients.
Pengolahan Statistik Asuhan Kesehatan Dalam Pengolahan Data Di Semen Padang Hospital
Authors: Putri Rahmanisa Dwi
Published: March 2024

Statistics are needed as a basis for decision making in every area of life, one of which is hospitals. Hospital statistics are statistics that use and process hospital service data sources to produce information, facts and knowledge related to hospital services. Results of data processing sourced from secondary data on inpatients at Semen Padang Hospital (SPH) for the period April 2019, patient data was 922, number of beds was 144 units. Data processing was carried out using Microsoft Excel and presented in the form of Barber Johnson tables and graphs. The results obtained were BOR 60%. BTR 0 times. TI 2 days and ALOS 3 days. Based on the results obtained, BOR and TI are at the efficient point, while BTR and ALOS are not at the efficient point. In table RL4a, the age group 45-64 years is 297 patients. The gender grouping was 449 patients male and 472 female patients, according to disposition, 907 patients were alive and 14 patients died. From the main diagnosis grouping based on ICD-10 code A01.0, 55 patients were diagnosed with Thypoid Fever. The frequency of the main diagnosis based on BAB in ICD-10 is CHAPTER I (Certain infectious and parasitic disease) at 14.66% or 135 patients. The procedure grouping based on ICD-9 is SC (Caesarean Section) with procedure code 77.99 for 34 patients. Based on the DTD code with code 002 Thypoid Fever there were 55 patients.
Analisis Kuantitatif Statistik Asuhan Kesehatan Rumah Sakit Islam Siti Rahmah Padang
Authors: Vernanda Aulia Sixta
Published: March 2024

Research at RSI SITI RAHMAH Padang can be used as a basis for hospitals in decision making, policy making so as to improve service quality. This study aims to determine the quantitative statistical analysis of inpatient health care at RSI SITI RAHMAH Padang. Data collection was carried out by direct observation at the medical record section in May 2021 at RSI SITI RAHMAH Padang, data obtained as many as 728 patients went home, with a total of 179 beds. From the main grouping of diagnoses based on ICD-10, there was a diagnosis of Delivery by caesarean section with code O82.9 as many as 35 patients, based on defecation on ICD-10, the highest diagnosis grouping was CHAPTER XV (Pregnancy, Childbirth And The Puerperium) with a percentage of 12 ,08% as many as 88 patients, the most procedures were Caesarean Section with a procedure code of 74.99 as many as 60 patients, the highest DTD code and definition was DTD 242.9 Pregnancy and Other Childbirth Diseases with a total of 44 patients. From the RL4a report, the most gender groupings were female patients as many as 405 patients and male patients as many as 323 patients, the disposition of living patients was 720 patients, while those who died were 8 patients. 93 patients. Based on the results of statistical data processing of health care concluded that BOR, BTR and TI are efficient.
Classification of Indian Festivals in Accordance with States of India Using Machine Learning
Authors: Dr. Shubhangi D.C  , Shweta
Published: March 2024

A religious festival is an annual communal celebration of a special religious event. There could be some very interesting things happening at these festivals. The algorithm sorts the celebrations according to the states. Gives background on the meaning of different holidays and instructions on how to observe their ceremonies and festivities. The system suggests several machine learning approaches for festival classification, including SVM and KNN. This method has a 94% accuracy rate.
IOT BASED PLANT MONITORING SYSTEM USING TELEGRAM BOT
Authors: Krishna, M. , Shivprasad Lingampally , Ravinder S. , Kumar G.Naveen
Published: March 2024

More and more it has become necessary to use technologies in the agriculture field. Agriculture is the backbone of our country; most of the people depend on agriculture. The main issue in agriculture is water scarcity. The water resource is not used in an effective manner, so the water is wasted. In order to overcome this irrigation process can be automated. The use of Internet of things in this field will be helpful to reduce the wastage of water. The use of sensors for IoT and actuators that make everything in the field more efficient and modern. We can do work easily and efficiently. The work can also be done within a very short period. By developing this intelligent system aimed at monitoring and controlling soil moisture in plants and plantations, it not only speeds up the work but also reduces the wastage of water by supplying required amount of water to the plant. It sends Telegram message which contains the details of the water content in the plant and can be viewed whenever we want.
Ventriculitis neonatal por Pseudomona fluorescens. Presentación de un caso clínico
Authors: Matos Furones Yelka
Published: March 2024

La ventriculitis secundaria a un meningocele abierto constituye una complicación neuroquirúrgica muy grave. La ventriculostomía continúa siendo un pilar importante en el monitoreo y el tratamiento. Ante la aparición de ventriculitis asociadas a gérmenes infrecuentes como la Pseudomona fluorescens, han surgido nuevos fármacos antimicrobianos como parte del tratamiento, al igual que se han propuesto vías de administración intraventriculares dentro de las nuevas investigaciones. Sin embargo, en la actualidad no existe suficiente evidencia científica que sustente con seguridad estas modalidades terapéuticas. Se presenta un caso de ventriculitis neonatal por Pseudomona fluorescens con evolución satisfactoria después de un drenaje ventricular y tratamiento con vancomicina intraventricular.
Synthesis of β-(4-chlorophenyl) lactic acid
Authors: Deng Xiling , Liu Xile
Published: March 2024

β-(4-chlorophenyl)lactic acid was synthetized via four steps of reaction, knoevenagel condensation, oxazolone ring-opening, hydrolysis and clemmensen reduction, staring from commercially available compound 4-chlorobenzaldehyde. β-(4-chlorophenyl) lactic acid and its mid-products were identified with 1H NMR, 13C NMR and MS. The spectra and physical constants were concordant with the corresponding structures and properties. The synthetic route we used has the advantages of abundant materials, simple process, mild reaction, without special equipments, much lower costs, ect.
Study on Microbial Degradation Characteristics of Diesel Contaminated Soil
Authors: Liu Weitao
Published: March 2024

A novel and highly effective Acinetobacter (L15) were obtained from soil by morphological observation, physiological and biochemical tests and 16 SrDNA sequencing. The optimal reaction environment of L15 at different temperatures was determined by shaking test, and the catalytic activity was measured. It was found that the bacteria could withstand n-cetane value above 5000 mg/L when the initial culture pH was 7, the inoculation amount was 5%, the shaking speed was 150 r/min, and the culture temperature was 30℃. Under the optimal 7-day fermentation condition, the degradation rate of n-cetane compounds reached 94.09%, and the decomposition rate of 3000 mg/L diesel oil was basically complete. The results showed that the bacteria had good potential for bioreactor in diesel contaminated soil.
(Poly)phenol-rich food and cardio-metabolic health
Authors: Hu Yu
Published: March 2024

Due to the changes in people's diet structure caused by economic development, cardio-metabolic disease has also become a concernthat more people care about or need to alleviate. (Poly)phenols, a chemical widely found in natural plants or fruits, such as, berries and tea, are thought to play an important role in alleviating cardiometabolic disease. As a result, (poly)phenols rich foods can offer positive effects in general cardiovascular system, and multiple evidence present in helping improve glycemic control, blood pressure and blood lipid level. However, controversy remains , especially in their effects on relieving metabolic syndrome, and the effects of (poly)phenol-rich foods on the cardiovascular system could be differed based on origin, for example, quercetin is associated with blood pressure, but cannot contribute to blood glucose problem as much as they provide in hypertension, while anthocyanins signally relieve glycemic disorder. Meanwhile, details such as the daily intake of (poly)phenols with health benefits remains to be explored.
Study on the Therapeutic Effect of shRNA Injected into Tail Vein on Parkinson’s Disease in Mice Based on SNCA Gene Mutation of α-Synuclein
Authors: Zhang Yutong , Dai Xiuzhi
Published: March 2024

Aim: This research aims to investigate the therapeutic effect of shRNA injected into the tail vein on Parkinson’s disease in mice based on SNCA gene mutation of α-synuclein and explore the migration mechanism of α-synuclein. Methods: SCNA +/+ mice are used to induce α-synuclein by tuberculin pff and then establish the model of Parkinson’s disease in mice. Besides, AAV-shRNA is used to set the control group and the experimental group at different times. Open-field test, tail suspension test, and immunofluorescence are adopted to explore the therapeutic effect of shRNA and the migration mechanism of α-synuclein. Results: shRNA inhibits P-α-syn in the brain of mice afflicted with Parkinson’s disease, which has obvious behavioral therapy. The whole brain invasion of α-synuclein in OB of the olfactory bulb occurs, while the invasion of α-synuclein in CPu of the dorsal striatum only exists in the downstream brain region. Conclusion: Intravenous injection of shRNA into the tail vein can effectively inhibit α-synuclein with symptomatic therapeutic effect on mice with Parkinson’s disease, and the earlier injection enables better therapeutic effect.
A review focus on the latest research progress of vitamin D in brain science
Authors: Liu Ziming
Published: March 2024

Vitamin D is a hormone precursor that is increasingly recognized for its broad impact, including on brain health. Vitamin D regulates neurotrophic growth factors and influences inflammation and thrombosis; all of which affect neurocognition. Lack of vitamin D can cause osteoporosis, decreased bone density, and fractures. The flesh of fatty fish and fish liver oils are the finest sources of vitamin D. Any mixture of calcifediol, obtained from vitamin D3, and ercalcidiol, derived from vitamin D2, is known as 25-hydroxyvitamin D, also known as 25(OH)D. Loss of cognitive abilities including thinking, remembering, and reasoning is referred to as dementia. Some dementia patients have emotional instability and personality changes. The most common type of dementia is Alzheimer's disease. The condition is gradual, starting with minor memory loss and potentially progressing to the loss of communication and environmental awareness. One of the characteristics of Alzheimer's disease, amyloid beta (Aβ) aggregates, are known to be cleared by vitamin D. Additionally, vitamin D may offer neuroprotection against tau hyperphosphorylation brought on by A. As a result, dementia and Alzheimer's disease are more likely to develop in those with low vitamin D levels. A stroke, also known as a brain attack, happens when a blood artery in the brain breaks or when something stops the flow of blood to a specific area of the brain. Parts of the brain suffer harm or degeneration in either scenario. In addition, the risk of stroke may be raised by vitamin D deficiency.
Degradation and remediation of environmental pollutants by algae
Authors: Jing Yike , Shen Qiyu , Zhang Meng , Han Zhuoxi , Zhao Wenzheng
Published: March 2024

The usage of a large number of industrial resources and the discharge of harmful pollutants have caused serious damage to the environment and ultimately affect the ecosystem and human health. Bioremediation is a green, sustainable and low-cost technology for the treatment of environmental pollutants, which includes the process of environmental remediation using plants, animals, microorganisms and so on. Among them, algae have the characteristics of rapid growth, wide distribution, strong stress resistance, large enrichment, and can convert pollutants into chemical products, so they play an important role in bioremediation. In this review, we introduce the types of pollutants existing in the environment, analyze the mechanism of algae for environmental remediation, and then describe the research progress of algae in the process of degradation and remediation of different pollutants. Finally, the shortages and limitations of bioremediation using algae are discussed, and its future development is prospected.
The Effect and Potential Mechanism of Microbiota in Major Depressive Disorder
Authors: Jiang Yong
Published: March 2024

Nowadays, Major depressive disorder is a global mental illness, for which antidepressant treatment with traditional drugs in the past is not effective. Gut microbiota (GM) plays a vital role in depression. The diversity of GM differs between patients inflicted with major depressive disorder and normal people. Besides, GM disorder is closely related to depression severity. This study found that anxiety as the clinical manifestation of major depressive disorder is highly intertwined with GM. There is a reasonable hypothesis about the influence of sleep disorder on patients with major depressive disorder. In addition, the GM system is considered to be related with depression. Meanwhile, this paper not only reviews the potential mechanism of gut-brain axis bidirectional action, but also investigates the existing relief measures and antidepressant interventions related to GM, and providing new insights for the depression pathogenesis and GM as adjuvant intervention therapy.
The Diagnostic Value of Stool-Based MicroRNA-135b in the Early Detection of Colorectal Cancer and the Potent Neuro Function of MiR-146a
Authors: Peng Juan
Published: March 2024

Background: Detecting microRNA (miRNA) in stool is a non-invasive approach for colorectal cancer (CRC) screening. This study aims to assess the diagnostic performance of stool-based microRNA-135b in detection of colorectal cancer and the role of miR-146a. Methods: To identify eligible studies that are well suited for diagnostic value of miR-135b in stool of colorectal cancer patients, we have evaluated 3 papers after systematic literature search of public database. The sensitivity and specificity were used to plot the summary receiver operator characteristic (SROC) curve and calculate the area under the SROC curve (AUC). The between-study heterogeneity was evaluated by Q test and I2 statistics. Importantly, we have also identified microRNA (miRNA) gene expression patterns by expression profiling. Moreover, we execute the pathway analysis to find the function of miR-146a. Results: A total of 3 studies from 19 articles were included for the meta-analysis according to the inclusion criteria. The overall analysis showed that microRNA-135b has a relatively good diagnostic performance in colorectal cancer, with a sensitivity of 0.685, a specificity of 0.813 and a partial AUC of 0.658. In stool samples, level of microRNA-135b was 2.21 fold change higher in subjects with CRC (P < 0.0001). Moreover, our study proved that miR-146a involved in the neuro and immune function. Interpretation: In conclusion, stool-based microRNA-135b shows a moderate level of overall diagnostic accuracy in diagnosis of CRC, which may present as auxiliary means for the diagnosis of colorectal cancer compare with colonoscopy. Further large-scale prospective studies are necessary to validate their potential applicability (miR-135b and miR-146a) combined with FBT methods in human cancer diagnosis.
How does CNB-2 act to its surroundings?
Authors: Zhu Motang
Published: March 2024

CNB-2 is a type of unharmful bacteria commonly found in water and dirt areas. It is sometimes used in biological experiments where it is given substances to see if the substance attracts it or not. There are two Typical experiments related to this, which is what will be discussed here.
Science et non-science dans le débat identitaire actuel
Authors: Gagné Learry
Published: March 2024

Le mouvement woke, largement défini comme une sensibilité aux discriminations dans nos sociétés et une volonté de s’y attaquer à la source, est la cible de très nombreuses critiques d’intellectuels qui n’acceptent pas de se faire traiter de xénophobes, même indirectement. Dans ce texte, je propose d’aborder ce qui me semble être la critique la plus fondamentale du wokisme, soit l’accusation d’« anti-scientisme ». C’est selon moi une stratégie qui permet aux « anti-wokes » d’invalider a priori les arguments de la gauche identitaire plutôt que d’avoir à en débattre.
Childhood lost: Revisiting policy interventions and way forward from child labour perspective
Authors:   Ministry of Labour & Employment, New Delhi, India, Bharti Rohit
Published: March 2024

The paper is based on the doctoral thesis titled “Child Labour, Rights and Rehabilitation: A Study of Select Stakeholders in Delhi”. The objective of the research was to know how far the government initiative has been proved effective and sustainable. The paper attempts to analyse the current circumstances and revisits the legislative interventions.
An attempt to cheat using GPT-4: findings, discussion and recommendations for academic staff and students
Authors: Mapletoft Nick , Price Andy , Smith Kevin , Mapletoft Olga , Elliott Michelle
Published: March 2024

This manuscript explores the use and detection of ChatGPT artificial intelligence (AI) content, in the academic setting.  The study involves faculty and student partnership at a Higher Education Provider (HEP), examining the implications of the chatbot's use in academic writing and its potential impact on educational practice.

We employ a dialogical approach in this Scholarship of Teaching and Learning (SoTL) study, mirroring the ChatGPT conversational style.  A former student uses ChatGPT-4 to rewrite an essay, and the generated content is evaluated by free-to-use AI checking tools, Turnitin, and the module tutor.

Our findings illustrate that while ChatGPT-4 could generate a passable assignment, it lacks depth, criticality, and contextualisation.  Further, AI checking tools, while useful, exhibit limitations. However, the generated content could serve as a starting point for students, suggesting a possible shift in the educational paradigm with AI's integration.

The manuscript also underscores the importance of understanding and navigating AI responsibly, calling for clear guidelines for AI use and improved methods of detecting AI generated content.  While AI has emerged as an efficient tool for generating academic content, our study highlights the necessity of human-centric learning and critical thinking skills in academia, emphasising that AI should not replace personal research.  We also discuss potential changes to assessment methods in response to AI advancements, recommending strategies for both academic staff and students.

Our findings have implications for educational institutions worldwide as AI tools become increasingly accessible, raising questions about academic integrity, pedagogical strategies, and the evolving relationship between technology and education.
Abordagem geográfica e os desafios por uma construção ativa
Authors: Lima Vitória Alves
Published: March 2024

O Encontro Nacional de Ensino de Geografia concentrou uma diversidade de temáticas essenciais ao fortalecimento do debate atual. Neste artigo, serão discutidas as ideias apresentadas no EDP/RE do Eixo – 08: natureza, meio ambiente e educação ambiental. Tem-se, como objetivos, apresentar um panorama geral da discussão realizada no referido eixo, identificar a proposta de educação ambiental que fundamenta os trabalhos e seu respectivo alcance, e verificar a existência de correlações entre as propostas de educação ambiental apresentadas e a perspectiva crítica da educação ambiental. Os procedimentos metodológicos adotados perpassam o levantamento bibliográfico e documental, escuta sensível e sistematização das informações coletadas. Como síntese dos resultados, destaca-se que uma parcela dos trabalhos corroborara com a proposta conservadora de educação ambiental, replicando em suas práticas os discursos fragmentadores baseados na proposta neoliberal comportamental e individualista. Portanto, o desafio da Geografia é desvincular-se do tratamento parcial das questões ambientais.
Jovens cotistas e espaço
Authors: De Vieira Souza Aline
Published: March 2024

Este artigo é produto da nossa pesquisa de mestrado intitulada “Jovens Cotistas e Cidade - tecendo novas espacialidades a partir do ingresso na UFJF” que contou com o financiamento da CAPES. Utilizando de revisão bibliográfica, aplicação de questionários online e entrevistas semiestruturadas, buscamos entender como o ingresso na universidade a partir da política de cotas irá se desdobrar em novas relações socioespaciais e novas possibilidades de experimentação da própria condição juvenil dos sujeitos. Para isso, dividimos o texto em duas partes, na primeira trabalhamos centralmente as categorias jovem e juventude em sua relação imbricada com o espaço, o que nos possibilita a abordagem da dimensão espacial da experiência universitária desses sujeitos. Na segunda parte olhamos para as falas dos jovens a partir do entendimento da juventude como direito, procurando entender os impactos da política de cotas na experimentação de suas juventudes.
The Game of Go as a Support in the Development of Cognitive Skills
Authors: Sámano Michelle Alejandra Wong
Published: March 2024

Go is a strategy game of oriental origin that has spread to many countries. With an antiquity of more than 2 ,500 years, its influence has expanded to Mexico, where it is currently practiced by people of all ages, without distinction of gender. Information on the web and studies indicate that practicing Go can influence the strengthening of cognitive skills of the people who play it. Therefore, the interest in this project is focused on studying the influence of the game Go on the development and strengthening of cognitive skills in people who play it in Mexico City and the metropolitan area, based on the evaluation and comparison of two groups: a group of 22 people who play Go and a group of 22 people who do not. The study was carried out in June 2023. Four cognitive skills were chosen for evaluation: reasoning, creativity, mathematical ability, and emotional intelligence. The evaluations consisted of exercises designated by school levels: primary, secondary, and high school and beyond. The data obtained was compiled into a table to create comparative graphs. The interpretation of the results revealed that the group that played Go obtained higher percentages in the evaluation of cognitive abilities, with mathematical ability showing the most significant improvement.
A FORMAÇÃO E A CERTIFICAÇÃO DE MEDIADORES EM PORTUGAL: UM MODELO ADAPTADO À NOVA ERA DIGITAL
Authors: Ribeiro Micael
Published: March 2024

Vivemos numa época de mudanças sociais constantes e, tal como em outros âmbitos empíricos, a mediação tende a ajustar-se ao novo circunstancialismo em que decorre o seu campo de aplicação. O ambiente pandémico vivenciado de forma mais presente entre 2020 e 2021 constituiu uma força motriz para a digitalização em diferentes âmbitos, e o campo da mediação não foi exceção. Mas será que os mediadores estão equipados com as ferramentas e competências profissionais para os desafios da mediação online? Portugal, tal como outros países europeus, implementou o seu sistema de certificação de mediadores. A Diretiva 2008/52/CE impulsionou a adoção de modelos de formação e certificação em toda a Europa. Mas nessa altura, o mundo digital era ainda uma realidade com menos desenvolvimento diante do que se verifica atualmente. Houve mesmo dúvidas sobre a existência de mediação em linha devido às dificuldades que a condução de uma mediação por meios telemáticos poderia causar, em parte em virtude da distância que imprimia no diálogo entre as partes. A pandemia encorajou a utilização de ferramentas digitais e mediadores em todo o mundo começaram a conduzir mediações através de ferramentas telemáticas. O que pretendemos estudar neste artigo é o modelo de certificação e formação de mediadores implementado em Portugal tentando compreender se este integra as competências digitais exigidas a um mediador, quando opera num ambiente eletrónico. Deverão essas competências ser exigidas a todos os mediadores ou deverão fazer parte de um plano de formação específico? Essas são algumas das questões que analisaremos neste trabalho.
GOVERNANÇA PÚBLICA – MEDIAÇÃO NA GESTÃO DO SERVIÇO
Authors: Silva de Vasconcelos Mendes Veiga Hélio
Published: March 2024

Alguns dilemas da modernidade se tornaram um gigantesco buraco negro de
significados no mundo contemporâneo, especialmente as relações sociais que evoluíram e se
tornaram mais complexas. Isso é notado em grande escala na seara tecnológica, com a redução
das distâncias entre pessoas e nações, por meio do fenômeno da globalização. Nessa quadra, o
relacionamento entre grupos não está alheio ao surgimento de novas formas de interação,
impulsionadas pelas mídias e redes sociais, principalmente no contexto “pós-pandemia”
(VEIGA, 2020, p.27). Inobstante, os procuradores dos órgãos públicos possuem atribuições
profícuas, um tipo de sabedoria que brota da vida cotidiana forense. Com recuo crítico. Com
análise. Longe do torpor inebriante, opacidade e repetição sem sentido, que só traz
segurança para quem não espera nada mais do que já se sabe (VEIGA, 2020, p.29). Todavia,
diante de nossas inquietações profissionais, trago à colação assertivas disseminadas na 11ª
Conferência do Fórum Mundial de Mediação. E, como não poderia ser diferente, os resultados
também se tornaram exponenciais. Ao exame, sem abandonar as fileiras da justiça multiportas,
o autor do presente levou consigo a vivencia de um conciliador à advocacia pública. De forma
inovadora e exitosa, chama atenção a inserção de sua pratica na função procurador, a
conciliação do ponto de vista do orgão público no exercício da função administrativa e a
postura de gestores de órgãos da administração direta e indireta. Ademais, sua contribuição,
sugerindo formas de tornar a justiça brasileira mais célere e desafogar o Judiciário, torna
o presente artigo de leitura essencial (VEIGA, 2023, p.11). Tal qual é erigida mister a
evolução da nobre missão das Procuradorias, quão essenciais a otimização do acesso à
justiça.
Customs monitoring experiment: administrative and legal characteristics
Authors: Agamagomedova Saniyat
Published: March 2024

The purpose of the work is an administrative and legal analysis of customs monitoring, an experiment on which has been launched since April 3, 2023. The subject of the study is the institute of customs monitoring, which has an administrative and legal nature and acts as a measure ensuring customs control. The author highlights the features of the regulatory regulation of customs monitoring, conducted a comparative legal analysis of customs monitoring with other types of monitoring, in particular with tax monitoring. The paper identifies the time and subject limits of customs monitoring, gives a description of its information support Formal legal and comparative legal methods, the method of system analysis and analysis of normative legal acts were used as research methods. The result of the work was the analysis of the regulatory framework of the Institute of customs monitoring, the characteristics of its evolution, the allocation of influence on the regulation of customs monitoring of legislation on state control (supervision), tax legislation. The characteristics of the information support of customs monitoring by the customs authorities and the participants of the experiment are given, the circle of participants and the period of the experiment are determined, as well as the frequency of collecting information for customs monitoring. A special contribution of the author to the study of the topic is the positioning of customs monitoring as a measure ensuring customs control and aimed at solving fiscal problems of the state. Noteworthy is the conclusion about the incompleteness of administrative and legal regulation of the institute of customs monitoring, the limitations of its use.
Nonuremic Calciphylaxis: A Rare and Unexpected Diagnosis of Necrotic Ulcers
Authors: Richardson Beth B. , Stees Marc A. , Gumbiner Brandon R.
Published: March 2024

Calciphylaxis is a rare and devastating condition found almost exclusively in patients with end-stage renal disease. Nonuremic calciphylaxis, an even more rare diagnosis, occurs in patients with preserved kidney function. We present a fatal case of nonuremic calciphylaxis with delayed and unexpected diagnosis despite early biopsy and testing. The patient presented with a 2-month history of painful ulceration to the left leg. Early biopsy was negative for calciphylaxis. Laboratory tests were negative for renal disease and autoimmune disorders. There was elevated parathyroid hormone (96 pg/mL) 3 months after initial presentation and documented cobalamin deficiency. The patient went on to develop wounds to both legs and her thighs. A second biopsy of a left thigh wound by means of the dermatology service revealed calciphylaxis. The purpose of this case report is to raise awareness of calciphylaxis as a differential diagnosis for chronic necrotic skin ulcers, especially in patients with preserved renal function and those on warfarin therapy.
The Impact of Forward Head Posture on Neck and Ankle Joint Position Sense: A Cross-Sectional Study
Authors: Abdel-Aziem Amr A. , Mosaad Dalia , Soliman Elsadat S. , Ibrahim Nouran A.
Published: March 2024

Background: Forward head posture (FHP) decreases the neck position sense and creates tension in the neck muscles, which inversely affects the mechanics of the distal joints through body myofascia. Thus, this study investigated the effects of FHP on neck and ankle joint position sense, and conducted a comparison between the joint position sense of the right and left ankle.

Methods: Fifty-seven subjects were assigned according to the craniovertebral angle (CVA) into the FHP group (CVA <49°; n = 27) or the control group (CVA >49°; n = 30). Head and ankle joint repositioning accuracy was measured by using a cervical range-of-motion device and an isokinetic dynamometer, respectively.

Results: There was a significant increase in the joint position error (JPE) of the cervical flexion, extension, and right and left side bending motions of the FHP group compared to the control group (P < .05). There were significant increases in the JPE of the right and left ankle dorsiflexion and plantarflexion of the FHP group compared to the healthy group (P < .05). Moreover, the JPE of the right ankle dorsiflexion and plantarflexion of the FHP group were significantly higher than the left ankle (P < .05).

Conclusions: The FHP decreases the position sense of cervical flexion, extension, and right and left side bending motions, and the plantarflexion and dorsiflexion of both ankle joints, especially the right ankle joint.
An important role for triglyceride in regulating spermatogenesis
Authors: Chao Charlotte F. , Pesch Yanina-Yasmin , Yu Huaxu , Wang Chenjingyi , Aristizabal Maria J. , Huan Tao , Tanentzapf Guy , Rideout Elizabeth J.
Published: March 2024

Drosophila
is a powerful model to study how lipids affect spermatogenesis. Yet, the contribution of neutral lipids, a major lipid group which resides in organelles called lipid droplets (LD), to sperm development is largely unknown. Emerging evidence suggests LD are present in the testis and that loss of neutral lipid- and LD-associated genes causes subfertility; however, key regulators of testis neutral lipids and LD remain unclear. Here, we show LD are present in early-stage somatic and germline cells within the
Drosophila
testis. We identified a role for triglyceride lipase
brummer
(
bmm
) in regulating testis LD, and found that whole-body loss of
bmm
leads to defects in sperm development. Importantly, these represent cell-autonomous roles for
bmm
in regulating testis LD and spermatogenesis. Because lipidomic analysis of
bmm
mutants revealed excess triglyceride accumulation, and spermatogenic defects in
bmm
mutants were rescued by genetically blocking triglyceride synthesis, our data suggest that
bmm
-mediated regulation of triglyceride influences sperm development. This identifies triglyceride as an important neutral lipid that contributes to
Drosophila
sperm development, and reveals a key role for
bmm
in regulating testis triglyceride levels during spermatogenesis.
Resident and recruited macrophages differentially contribute to cardiac healing after myocardial ischemia
Authors: Weinberger Tobias , Messerer Denise , Joppich Markus , Fischer Max , Garcia Clarisabel , Kumaraswami Konda , Wimmler Vanessa , Ablinger Sonja , Räuber Saskia , Fang Jiahui , Liu Lulu , Liu Wing Han , Winterhalter Julia , Lichti Johannes , Tomas Lukas , Esfandyari Dena , Percin Guelce , Salamanca Sandra Martin , Hidalgo Andres , Waskow Claudia , Engelhardt Stefan , Todica Andrei , Zimmer Ralf , Pridans Clare , Gomez-Perdiguero Elisa , Schulz Christian
Published: March 2024

Cardiac macrophages are heterogenous in phenotype and functions, which has been associated with differences in their ontogeny. Despite extensive research, our understanding of the precise role of different subsets of macrophages in ischemia/reperfusion injury remains incomplete. We here investigated macrophage lineages and ablated tissue macrophages in homeostasis and after I/R injury in a CSF1R-dependent manner. Genomic deletion of a fms-intronic regulatory element (FIRE) in the Csf1r locus resulted in specific absence of resident homeostatic and antigen-presenting macrophages, without affecting the recruitment of monocyte-derived macrophages to the infarcted heart. Specific absence of homeostatic, monocyte-independent macrophages altered the immune cell crosstalk in response to injury and induced proinflammatory neutrophil polarization, resulting in impaired cardiac remodelling without influencing infarct size. In contrast, continuous CSF1R inhibition led to depletion of both resident and recruited macrophage populations. This augmented adverse remodelling after I/R and led to an increased infarct size and deterioration of cardiac function. In summary, resident macrophages orchestrate inflammatory responses improving cardiac remodelling, while recruited macrophages determine infarct size after I/R injury. These findings attribute distinct beneficial effects to different macrophage populations in the context of myocardial infarction.
Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila
Authors: Ma Zhixin , Wang Wenshu , Yang Xiaojing , Rui Menglong , Wang Su
Published: March 2024

Stem cell niche is critical for regulating the behavior of stem cells. Drosophila neural stem cells (Neuroblasts, NBs) are encased by glial niche cells closely, but it still remains unclear whether glial niche cells can regulate the self-renewal and differentiation of NBs. Here, we show that ferritin produced by glia, cooperates with Zip13 to transport iron into NBs for the energy production, which is essential to the self-renewal and proliferation of NBs. The knockdown of glial ferritin encoding genes causes energy shortage in NBs via downregulating aconitase activity and NAD+ level, which leads to the low proliferation and premature differentiation of NBs mediated by Prospero entering nuclei. More importantly, ferritin is a potential target for tumor suppression. In addition, the level of glial ferritin production is affected by the status of NBs, establishing a bicellular iron homeostasis. In this study, we demonstrate that glial cells are indispensable to maintain the self-renewal of NBs, unveiling a novel role of the NB glial niche during brain development.
Glial ferritin maintains neural stem cells via transporting iron required for self-renewal in Drosophila
Authors: Ma Zhixin , Wang Wenshu , Yang Xiaojing , Rui Menglong , Wang Su
Published: March 2024

Stem cell niche is critical for regulating the behavior of stem cells.
Drosophila
neural stem cells (Neuroblasts, NBs) are encased by glial niche cells closely, but it still remains unclear whether glial niche cells can regulate the self-renewal and differentiation of NBs. Here we show that ferritin produced by glia, cooperates with Zip13 to transport iron into NBs for the energy production, which is essential to the self-renewal and proliferation of NBs. The knockdown of glial ferritin encoding genes causes energy shortage in NBs, which leads to the low proliferation and premature differentiation of NBs. Moreover, the level of glial ferritin production is affected by the status of NBs, establishing a bicellular iron homeostasis. In this study, we demonstrate that glial cells are indispensable to maintain the self-renewal of NBs, unveiling a novel role of the NB glial niche during brain development.
A Statistical Framework for Analysis of Trial-Level Temporal Dynamics in Fiber Photometry Experiments
Authors: Loewinger Gabriel , Cui Erjia , Lovinger David , Pereira Francisco
Published: March 2024

Fiber photometry has become a popular technique to measure neural activity in vivo, but common analysis strategies can reduce detection of effects because they condense
within-trial
signals into summary measures, and discard trial-level information by averaging
across-trials
. We propose a novel photometry statistical framework based on functional linear mixed modeling, which enables hypothesis testing of variable effects at
every trial time-point
, and uses trial-level signals without averaging. This makes it possible to compare the timing and magnitude of signals across conditions while accounting for between-animal differences. Our framework produces a series of plots that illustrate covariate effect estimates and statistical significance at each trial time-point. By exploiting signal autocorrelation, our methodology yields
joint
95% confidence intervals that account for inspecting effects across the entire trial and improve the detection of event-related signal changes over common multiple comparisons correction strategies. We reanalyze data from a recent study proposing a theory for the role of mesolimbic dopamine in reward learning, and show the capability of our framework to reveal significant effects obscured by standard analysis approaches. Our method identifies two dopamine components with distinct temporal dynamics that may be hard to explain under currently competing learning theories. In simulation experiments, our methodology yields improved statistical power over common analysis approaches. Finally, we provide an open-source package implementing our framework.
Activation of Polycystin-1 Signaling by Binding of Stalk-derived Peptide Agonists
Authors: Pawnikar Shristi , Magenheimer Brenda S. , Nevarez Munoz Ericka , Haldane Allan , Maser Robin L. , Miao Yinglong
Published: March 2024

Polycystin-1 (PC1) is the membrane protein product of the PKD1 gene whose mutation is responsible for 85% of the cases of autosomal dominant polycystic kidney disease (ADPKD). ADPKD is primarily characterized by the formation of renal cysts and potential kidney failure. PC1 is an atypical G protein-coupled receptor (GPCR) consisting of 11 transmembrane helices and an autocatalytic GAIN domain that cleaves PC1 into extracellular N-terminal (NTF) and membrane-embedded C-terminal (CTF) fragments. Recently, signaling activation of the PC1 CTF was shown to be regulated by a stalk tethered agonist (TA), a distinct mechanism observed in the adhesion GPCR family. A novel allosteric activation pathway was elucidated for the PC1 CTF through a combination of Gaussian accelerated molecular dynamics (GaMD), mutagenesis and cellular signaling experiments. Here, we show that synthetic, soluble peptides with 7 to 21 residues derived from the stalk TA, in particular, peptides including the first 9 residues (p9), 17 residues (p17) and 21 residues (p21) exhibited the ability to re-activate signaling by a stalkless PC1 CTF mutant in cellular assays. To reveal molecular mechanisms of stalk peptide-mediated signaling activation, we have applied a novel Peptide GaMD (Pep-GaMD) algorithm to elucidate binding conformations of selected stalk peptide agonists p9, p17 and p21 to the stalkless PC1 CTF. The simulations revealed multiple specific binding regions of the stalk peptide agonists to the PC1 protein including an “intermediate” bound yet inactive state. Our Pep-GaMD simulation findings were consistent with the cellular assay experimental data. Binding of peptide agonists to the TOP domain of PC1 induced close TOP-putative pore loop interactions, a characteristic feature of the PC1 CTF signaling activation mechanism. Using sequence covariation analysis of PC1 homologs, we further showed that the peptide binding regions were consistent with covarying residue pairs identified between the TOP domain and the stalk TA. Therefore, structural dynamic insights into the mechanisms of PC1 activation by stalk-derived peptide agonists have enabled an in-depth understanding of PC1 signaling. They will form a foundation for development of PC1 as a therapeutic target for the treatment of ADPKD.
Evaluation of the Properties of High Strength Lightweight Concrete with High Temperature History
Authors: Im Ha-Jun , Kim Won-Chang , Jeong Keesin , Lee Tae-Gye
Published: March 2024

In this study, we evaluated the compressive strength and ultrasonic velocity based on the temperature and age of ordinary aggregate and lightweight aggregate concrete (30 and 60 MPa) and examined their correlation. The unit weight and compressive strength of ordinary aggregate and lightweight aggregate concrete were measured to evaluate the mechanical properties and examine the correlation between ultrasonic velocity and compressive strength. The W/B ratio was set at 0.41 and 0.28, and measurements were made at 1, 3, 7, 28, 56, and 91 days. The physical properties were evaluated at 23, 100, 200, 300, 500, and 700 ℃. In all test specimens, compressive strength and ultrasonic speed increased with age; and the higher the temperature, the lower the compressive strength and ultrasonic speed. By analyzing the correlation between ultrasonic velocity and compressive strength, a strength prediction equation in the form of an exponential function was found. Moreover, from the error rate test, we confirmed that the strength prediction equation generally had an error rate of 15% or less.
Study on the Performance of Sandwich Pressurization System
Authors: Kim Hee-Moon , Choi Han-Bit , Choi Don-Mook
Published: March 2024

This study aims to outline a verification plan for domestic scenarios using the sandwich pressurization method. We employed four methods: T.A.B, hot smoke test, FDS, and pathfinder. T.A.B and fire and evacuation simulation did not exhibit any issues. However, the smoke flow was observed in both the upper and lower layers during the H.S.T. Evacuation safety was confirmed through simulation, including the adequacy of the procedure. Nonetheless, the introduction of smoke in the hot smoke test highlighted the need for enhancements to the sandwich pressurization method. Consequently, the hot smoke test, alongside T.A.B and fire and evacuation simulations, will enhance verification standards for the sandwich pressurization method.