bluuebunny/crossref_metadata_2025 huggingface dataset:
Essential Oils as Repellents against Arthropods
Authors: Lee Mi Young
Published: October 2018

The development of effective and safe repellents against arthropods is very important, because there are no effective vaccines against arthropod-borne viruses (arboviruses) and parasites. Arboviruses and parasites are transmitted to humans from arthropods, and mosquitoes are the most common arthropods associated with dengue, malaria, and yellow fever. Enormous efforts have been made to develop effective repellents against arthropods, and thus far synthetic repellents have been widely used. However, the use of synthetic repellents has raised several concerns in terms of environmental and human health risks and safety. Thus, plant essential oils (EOs) have been widely used as an alternative to synthetic repellents. In this review, we briefly introduce and summarize recent studies that have investigated EOs as insect repellents. Current technology and research trends to develop effective and safe repellents from plant EOs are also described in this review.
Associations between Attention-Deficit Hyperactivity Disorder (ADHD) Treatment and Patient Nutritional Status and Height
Authors: Granato Mariana F. , Ferraro Alexandre A. , Lellis Denise M. , Casella Erasmo B.
Published: October 2018

Attention-deficit hyperactivity disorder (ADHD) has been found to co-occur frequently with obesity, although the reasons for this association are unknown. The aim of this study was to compare the nutritional profile of a Brazilian cohort of ADHD patients with that of the general population and to analyze the association between ADHD drug treatment (with methylphenidate), nutritional status, and height of these individuals. In the first phase of the study, we designed the nutritional and height profile of 93 ADHD patients (5.1 to 13.8 years old) and compared it to a control group. In the second phase, we analyzed the association of the use of methylphenidate with nutritional status and height. The results showed that the prevalence of overweight/obesity was statistically higher in the cohort of ADHD patients compared to controls (40.9% vs. 34.7%;P<0.05). After treating ADHD patients with methylphenidate, a statistically significant decrease in the BMIz-score was observed (0.695 vs. 0.305;P<0.01). On the other hand, no significant impact on height was detected after treatment (0.189 vs. 0.248;P=0.298). In conclusion, the results suggest that the use of methylphenidate in patients who have ADHD and obesity is relevant not only for controlling ADHD symptoms but also for improving the nutritional status of these individuals. Moreover, the treatment did not affect the patients’ height.
A Metaheuristic Method for the Task Assignment Problem in Continuous-Casting Production
Authors: Hu Hongtao , Wu Yiwei , Wang Tingsong
Published: October 2018

The steelmaking and continuous-casting (SCC) process in integrated iron and steel enterprises can be described as two stages: the upstream stage and downstream stage. Raw materials are transformed into molten steel in the upstream stage, while the downstream stage is responsible for transforming molten steel which is released at regular intervals and has a limited time for being turned into slabs. This article focuses on the task assignment problem in the downstream stage within the given information resulting from the upstream stage. This problem is formulated as a nonlinear mixed-integer programming model aimed at minimizing total tardiness within the resource constraints and time windows constraints for the tasks. An improved solution algorithm based on particle swam optimization is developed to efficiently solve the proposed model. Finally, computational experiments are implemented to evaluate the performance of the solution algorithm in terms of solution quality and computational time.
Best Proximity Point Theorems for Cyclic Relatively ρ-Nonexpansive Mappings in Modular Spaces
Authors: Chaira Karim , Lazaiz Samih
Published: October 2018

In this paper we introduce the notion of proximal ρ-normal structure of pair of ρ-admissible sets in modular spaces. We prove some results of best proximity points in this setting without recourse to Zorn’s lemma. We provide some examples to support our conclusions.
Fecal Microbiota Transplantation Can Alleviate Gastrointestinal Transit in Rats with High-Fat Diet-Induced Obesity via Regulation of Serotonin Biosynthesis
Authors: Sun Wenjing , Guo Yan , Zhang Shirong , Chen Zhihui , Wu Kangqi , Liu Qin , Liu Kaijun , Wen Liangzhi , Wei Yanling , Wang Bin , Chen Dongfeng
Published: October 2018

Aim. We tested the hypothesis that fecal microbiota transplantation (FMT) could regulate the biotransformation of bile acids, such as deoxycholic acid (DCA) and cholic acid (CA), which in turn regulate the biosynthesis of serotonin in the gut and relieve gastrointestinal dysmotility in high-fat diet- (HFD-) induced obesity in rats. Methods. Male Sprague-Dawley rats were randomly divided into the control diet group, HFD group, and HFD-fed with receiving FMT. HFD was fed for 12 weeks. At the end of two-week HFD, FMT was carried out for two weeks. The gastrointestinal transit, serotonin concentration, the expression of tryptophan hydroxylase 1 (TPH1) and serotonin reuptake transporter (SERT), and the levels of bile acids in intestinal contents were examined. Results. Compared with the control group, the gastrointestinal transit and small intestinal serotonin concentration of HFD-fed rats were increased. In HFD-fed rats, TPH1 protein expression was increased significantly, while SERT protein expression was decreased, but not significant. The levels of CA and DCA in intestinal contents were also significantly increased in HFD-fed rats compared with the control group. After HFD-fed rats receiving FMT treatment, the gastrointestinal transit, small intestinal serotonin concentration, and TPH1 expression were decreased, while SERT expression was not affected. Moreover, the levels of CA and DCA in intestinal contents were also decreased. Conclusions. FMT could alleviate small intestinal transit in the HFD-fed rats by regulating the serotonin biosynthesis. In this process, CA and DCA may be related to the regulation of synthesis of serotonin.
On Vaccination Strategies for a SISV Epidemic Model Guaranteeing the Nonexistence of Endemic Solutions
Authors: Alonso-Quesada S. , De la Sen M. , Nistal R.
Published: October 2018

A vaccination strategy based on the state feedback control theory is proposed. The objective is to fight against the propagation of an infectious disease within a host population. This propagation is modelled by means of a SISV (susceptible-infectious-susceptible-vaccinated) epidemic model with a time-varying whole population and with a mortality directly associated with the disease. The vaccination strategy adds four free-design parameters, with three of them being the feedback gains of the vaccination control law. The other one is used to switch off the vaccination if the proportion of susceptible individuals is smaller than a prescribed threshold. The paper analyses the positivity of such a model under the proposed vaccination strategy as well as the conditions for the existence of the different equilibrium points of its normalized model. The fact that an appropriate adjustment of the control gains avoids the existence of endemic equilibrium points in the normalized SISV model while guaranteeing the existence of a unique disease-free equilibrium point being globally exponentially stable is proved. This is a relevant novelty dealt with in this paper. The persistence of the infectious disease within a host population irrespective of the growing properties of the whole population can be avoided in this way. Such theoretical results are mathematically proved and, also, they are illustrated by means of simulation examples. Moreover, the performance of the proposed vaccination strategy in several real situations is studied in some simulation examples. One of them deals with the presence of uncertainties, which affects the synthesis of the vaccination control law, in the measures of the subpopulations of the model.
The Resilience of Public Policies in Economic Development
Authors: Castañeda Gonzalo , Guerrero Omar A.
Published: October 2018

This paper studies the resilience of public policies that governments design for catalyzing economic development. This property depends on the extent to which behavioral heuristics and spillover effects allow policymakers to attain their original goals when a particular policy cannot be funded as originally planned. This scenario takes place, for example, when unanticipated events such as natural disasters or political turmoil obstruct the use of resources to advance certain policy issues, e.g., infrastructure or labor reforms. Here, we analyze how the adaptive capacity of the policy‐making process generates resilience in the face of disruptions. In order to estimate the allocation of resources across policies, we employ a computational model that accounts for diverse social mechanisms, for example, coevolutionary learning and network interdependencies. In our simulations, we use a data set of 117 countries on 79 development indicators over an 11‐year period. Then, we calculate a resilience score corresponding to each development indicator via counter‐factual analysis of policy disruptions. Next, we assess whether some development strategies produce resilient/fragile policy profiles. Finally, by studying the relationship between policy resilience and policy priority, we determine which issues are bottlenecks to economic development.
Loss of RBMS3 Confers Platinum Resistance in Epithelial Ovarian Cancer via Activation of miR-126-5p/β-catenin/CBP signaling
Authors: Wu Geyan , Cao Lixue , Zhu Jinrong , Tan Zhanyao , Tang Miaoling , Li Ziwen , Hu Yameng , Yu Ruyuan , Zhang Shuxia , Song Libing , Li Jun
Published: October 2018

Purpose:

The development of resistance to platinum-based chemotherapy remains the unsurmountable obstacle in cancer treatment and consequently leads to tumor relapse. This study aims to investigate the mechanism by which loss of RBMS3 induced chemoresistance in epithelial ovarian cancer (EOC).

Experimental Design:

FISH and IHC were used to determine deletion frequency and expression of RBMS3 in 15 clinical EOC tissues and 150 clinicopathologically characterized EOC specimens. The effects of RBMS3 deletion and CBP/β-catenin antagonist PRI-724 in chemoresistance were examined by clone formation and Annexin V assays in vitro, and by intraperitoneal tumor model in vivo. The mechanism by which RBMS3 loss sustained activation of miR-126-5p/β-catenin/CBP signaling and the effects of RBMS3 and miR-126-5p competitively regulating DKK3, AXIN1, BACH1, and NFAT5 was explored using CLIP-seq, RIP, electrophoretic mobility shift, and immunoblotting and immunofluorescence assays.

Results:

Loss of RBMS3 in EOC was correlated with the overall and relapse-free survival. Genetic ablation of RBMS3 significantly enhanced, whereas restoration of RBMS3 reduced, the chemoresistance ability of EOC cells both in vitro and in vivo. RBMS3 inhibited β-catenin/CBP signaling through directly associating with and stabilizing multiple negative regulators, including DKK3, AXIN1, BACH1, and NFAT5, via competitively preventing the miR-126-5p–mediated repression of these transcripts. Importantly, cotherapy of CBP/β-catenin antagonist PRI-724 induced sensitization of RBMS3-deleted EOC to platinum therapy.

Conclusions:

Our results demonstrate that genetic ablation of RBMS3 contributes to chemoresistance and PRI-724 may serve as a potential tailored treatment for patients with RBMS3-deleted EOC.
Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility
Authors: Kaur Amanpreet , Ecker Brett L. , Douglass Stephen M. , Kugel Curtis H. , Webster Marie R. , Almeida Filipe V. , Somasundaram Rajasekharan , Hayden James , Ban Ehsan , Ahmadzadeh Hossein , Franco-Barraza Janusz , Shah Neelima , Mellis Ian A. , Keeney Frederick , Kossenkov Andrew , Tang Hsin-Yao , Yin Xiangfan , Liu Qin , Xu Xiaowei , Fane Mitchell , Brafford Patricia , Herlyn Meenhard , Speicher David W. , Wargo Jennifer A. , Tetzlaff Michael T. , Haydu Lauren E. , Raj Arjun , Shenoy Vivek , Cukierman Edna , Weeraratna Ashani T.
Published: October 2018

Physical changes in skin are among the most visible signs of aging. We found that young dermal fibroblasts secrete high levels of extracellular matrix (ECM) constituents, including proteoglycans, glycoproteins, and cartilage-linking proteins. The most abundantly secreted was HAPLN1, a hyaluronic and proteoglycan link protein. HAPLN1 was lost in aged fibroblasts, resulting in a more aligned ECM that promoted metastasis of melanoma cells. Reconstituting HAPLN1 inhibited metastasis in an aged microenvironment, in 3-D skin reconstruction models, and in vivo. Intriguingly, aged fibroblast-derived matrices had the opposite effect on the migration of T cells, inhibiting their motility. HAPLN1 treatment of aged fibroblasts restored motility of mononuclear immune cells, while impeding that of polymorphonuclear immune cells, which in turn affected regulatory T-cell recruitment. These data suggest that although age-related physical changes in the ECM can promote tumor cell motility, they may adversely affect the motility of some immune cells, resulting in an overall change in the immune microenvironment. Understanding the physical changes in aging skin may provide avenues for more effective therapy for older patients with melanoma.

Significance:

These data shed light on the mechanochemical interactions that occur between aged skin, tumor, and immune cell populations, which may affect tumor metastasis and immune cell infiltration, with implications for the efficacy of current therapies for melanoma.

See related commentary by Marie and Merlino, p. 19.

This article is highlighted in the In This Issue feature, p. 1
Anaesthesia and Perioperative Care for Transoral Robotic Surgery
Authors: Jeyarajah J. , Ahmad I. , Jacovou Eva
Published: October 2018

Minimally invasive surgical techniques have gained increasing interest in recent years for their conferred recovery and postoperative advantages. Robot-assisted surgery requires special consideration for anaesthetic and perioperative management. The introduction of robot- assisted intra-oral surgery has important implications on anaesthesia provision, airway management and patient safety. Due to its relatively novel use we explore these considerations alongside our own experience in this field.
Surgery for Gastrointestinal Stromal Tumors: State of the Art of Laparoscopic Resection and Surgery for M1 Tumors
Authors: Ronellenfitsch Ulrich , Hohenberger Peter
Published: October 2018

Background: The principles of surgery for primary gastrointestinal stromal tumor (GIST) are resection with clear margins without lymphadenectomy, thus enabling organ-preserving resection in many cases. Tumor rupture needs to be avoided, because it entails peritoneal sarcomatosis. Given these preconditions, there is a rationale for laparoscopic resection of primary GIST. In metastatic GIST, surgery cannot achieve cure, but constitutes an important cornerstone of treatment. Resection can be performed either for residual lesions in responding patients, for focally progressive lesions, or as palliative measure in generalized progression. Methods: Selective literature review. Results: There is ample evidence on laparoscopic resection of gastric GIST, but none from randomized trials. The studies show favorable perioperative outcomes and suggest adequate oncological results; however, a direct comparison to open resection is difficult. For surgery in M1 stages, survival outcomes are better for resection in generalized response than in focal progression. Perioperative morbidity is acceptable. Surgery in generalized progression does not prolong survival and bears relevant morbidity risks. Conclusion: Laparoscopy seems an adequate surgical approach for primary gastric GIST, as long as the surgical principles relevant for this entity are respected. For other tumor sites, there is no sufficient evidence available. In M1 stages, selected patients may benefit from surgery. Survival differences between resection at different stages probably mirror the biology of the disease rather than the effect of the timing of the operation.
A New Transcutaneous Method for Breast Cancer Detection with Dogs
Authors: Thuleau Aurélie , Gilbert Caroline , Bauër Pierre , Alran Séverine , Fourchotte Virginie , Guillot Eugénie , Vincent-Salomon Anne , Kerihuel Jean-Charles , Dugay José , Semetey Vincent , Kriegel Irène , Fromantin Isabelle
Published: October 2018

We developed a new transcutaneous method for breast cancer detection with dogs: 2 dogs were trained to sniff skin secretion samples on compresses that had been worn overnight by women on their breast, and to recognize a breast cancer sample among 4 samples. During the test, the dogs recognized 90.3% of skin secretion breast cancer samples. This proof-of-concept study opens new avenues for the development of a reliable cancer diagnostic tool integrating olfactory abilities of dogs.
Bioptically Proven “Anticoagulation-Related Nephropathy“ Induced by Dual Antiplatelet Therapy
Authors: Krátká Karolína , Havrda Martin , Honsová Eva , Rychlík Ivan
Published: October 2018

Anticoagulation-related nephropathy (ARN) is a significant and underdiagnosed complication in patients who receive anticoagulation therapy. It is characterized by acute kidney injury in the setting of excessive anticoagulation defined as an international normalized ratio > 3.0 in patients treated with warfarin. A definitive diagnosis is made by renal biopsy showing acute tubular necrosis with obstruction of the tubuli by red blood cell casts. However, the evidence shows that ARN can occur during treatment with novel oral anticoagulants as well. Although it has been suggested that antiplatelet therapy, such as aspirin, might contribute to coagulopathy (and therefore the hypothetical risk of ARN), there are no reports of ARN induced by antiplatelet therapy according to our knowledge. It is also reported that glomerular lesions (i.e., kidney disease) represent a risk factor for ARN. We present a case of an 82-year-old man who developed biopsy-proven ARN after the administration of dual antiplatelet therapy with no previous anticoagulation treatment and normal coagulation tests.
Lipemia Retinalis, Macular Edema, and Vision Loss in a Diabetic Patient with a History of Type IV Hypertriglyceridemia and Pancreatitis
Authors: Hinkle John W. , Relhan Nidhi , Flynn Jr. Harry W.
Published: October 2018

Background: Lipemia retinalis is a rare but known complication of elevated serum triglycerides. This case describes the clinical course of a diabetic patient who presented with lipemia retinalis and macular edema, which responded to systemic and local treatments. Case Report: A 40-year-old female with a history of type II diabetes mellitus, hypertriglyceridemia, and pancreatitis presented with decreased vision in the left eye. She had peripapillary and macular edema, intraretinal hemorrhages, and prominent exudates in the setting of lipemia retinalis due to type IV hypertriglyceridemia. She was treated with serial intravitreal bevacizumab injections for macular edema and systemic lipid lowering therapy, and her visual acuity improved back to baseline. Conclusions: In the setting of lipemia retinalis and hypertriglyceridemia, the current patient developed macular edema and vision loss. The macular edema was treated with intravitreal injections of bevacizumab, and the patient experienced a rapid recovery of visual acuity.
Circular RNA Expression Profile and Analysis of Their Potential Function in Psoriasis
Authors: Qiao Meng , Ding Jian , Yan Jianjun , Li Ronghua , Jiao Jian , Sun Qing
Published: October 2018

Background/Aims: Circular RNAs (circRNAs) are evolutionary conserved circular non-coding RNAs that play a role in several diseases by sequestering (sponging) microRNAs (miRNAs). However, their role in psoriasis remains unclear. In the present study, we investigated the expression of circRNAs and analyzed their potential functions in psoriasis. Methods: The SBC human ceRNA array V1.0 was used to analyze circRNA expression in psoriatic lesions and normal healthy skin tissues. Functional analyses were performed using Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. Putative miRNA response elements (MREs) were identified using miRNA target prediction software. Six upregulated circRNAs were verified by quantitative real-time reverse transcription polymerase chain reaction in psoriatic lesions and healthy skin tissues. Results: A total of 4956 circRNAs (3016 upregulated and 1940 downregulated; fold change ≥2 and p< 0.05) were identified as differentially expressed in psoriasis. Furthermore, 4405 MREs were identified among the differentially expressed circRNAs. hsa_circ_0061012 was upregulated in psoriatic lesions compared with normal healthy skin tissues. The top five MREs of hsa_circ_0061012 were hsa-miR-7157-5p, hsa-miR-4769-3p, hsa-miR-6817-5p, hsa-miR-4310, and hsa-miR-6882-3p. GO analysis was carried out to investigate the biological functions enriched among the upregulated targets of five miRNAs in psoriasis. The GO analysis identified that most of top 30 of GO enrichment are related to psoriasis. Conclusion: hsa_circ_0061012 might be a candidate biomarker for psoriasis. The results provide a new perspective for a better understanding of ceRNA-mediated gene regulation in psoriasis, and provide a novel theoretical basis for further studies on the function of circRNA in psoriasis.
Mining Prognostic Significance of MEG3 in Human Breast Cancer Using Bioinformatics Analysis
Authors: Cui Xiangrong , Yi Qin , Jing Xuan , Huang Yue , Tian Jie , Long Chunlan , Xiang Zhongping , Liu Jianping , Zhang Chunmin , Tan Bin , Li Yasha , Zhu Jing 
Published: October 2018

Background/Aims: Maternally expressed gene 3 (MEG3) is an imprinted gene with maternal expression, which may function as a tumor suppressor by inhibiting angiogenesis. To identify the prognostic value of MEG3 in breast cancer, systematic analysis was performed in this study. Methods: To evaluate gene alteration during breast carcinogenesis, we explored MEG3 expression using the Serial Analysis of Gene Expression Genie suite and Oncomine analysis. The prognostic roles of MEG3 in breast cancer were investigated using the PrognoScan database. The heat map and methylation status of MEG3 were determined using the UCSC Genome Browser. Results: We found that MEG3 was more frequently downregulated in breast cancer than in normal tissues and this correlated with prognosis. However, estrogen receptor and progesterone receptor status were found to be positively correlated with MEG3 expression. Conversely, basal-like status, triple-negative breast cancer status, and Scarff Bloom & Richardson grade criterion were negatively correlated with MEG3 expression. Following data mining in multiple big data databases, we confirmed a positive correlation between MEG3 and heparan sulfate proteoglycan 2 (HSPG2) expression in breast cancer tissues. Conclusion: MEG3 could be adopted as a marker to predict the prognosis of breast cancer with HSPG2. However, large-scale and comprehensive research is needed to clarify our results.
Gq-Induced Apoptosis is Mediated by AKT Inhibition That Leads to PKC-Induced JNK Activation
Authors: Nadel Guy , Yao Zhong , Ben-Ami Ido , Naor Zvi , Seger Rony
Published: October 2018

Background/Aims: Gq protein-coupled receptors (GqPCRs) regulate various cellular processes including mainly proliferation and differentiation. In a previous study, we found that in prostate cancer cells, the GqPCR of GnRH induces apoptosis by reducing the PKC-dependent AKT activity and elevating JNK phosphorylation. Since it was thought that GqPCR induces mainly activation of AKT, we undertook to examine how general is this phenomenon and understand its signaling. Methods: We used various cells to follow the phosphorylation of signaling components using western blotting. Results: In a screen of 21 cell lines, we found that PKC activation results in the reduction of AKT activity, which correlates nicely to JNK activation and in some cases to apoptosis. To further understand the signaling pathways involved in this stimulation, we studied in detail the SVOG-4O and αT3-1 cells. We found that PGF2α and GnRH agonist (GnRH-a) indeed induce significant Gq- and PKC- dependent apoptosis in these cells. This is mediated by two signaling branches downstream of PKC, which converge at the level of MLK3 upstream of JNK. One branch consists on c-Src activation of the JNK cascade and the second involves reduction of AKT activity that alleviates its inhibitory effect on MLK3, to allow the flow of the c-Src signal to JNK. At the MAPKK level, we found that the signal is transmitted by MKK7 and not MKK4. Conclusion: Our results present a general mechanism that mediates a GqPCR-induced, death receptors-independent, apoptosis in physiological, as well as cancer-related systems.
lncRNA AFAP1-AS1 Promotes Migration and Invasion of Non-Small Cell Lung Cancer via Up-Regulating IRF7 and the RIG-I-Like Receptor Signaling Pathway
Authors: Tang Xiao-Di , Zhang Duo-Duo , Jia Linpei , Ji Wei , Zhao Yu-Shuang 
Published: October 2018

Background/Aims: Accumulating evidence has highlighted the importance of long non-coding RNAs (lncRNAs) as competing endogenous RNAs (ceRNAs) in tumor biology. Among others, actin filament-associated protein 1 antisense RNA 1 (AFAP1-AS1) has been associated with non-small cell lung cancer (NSCLC). However, it remains unclear how AFAP1-AS1 participates in the development and progression of NSCLC. Methods: The peripheral blood samples were collected from patients with NSCLC. White blood cell subsets were classified and levels of interleukin (IL)-10, IL-12 and IFN-γ in serum were measured. We then identified its target gene of AFAP1-AS1 via bioinformatics methods. NSCLC cell line with the highest expression of AFAP1-AS1, i.e. H1975 was selected for in vitro experiments. A series of inhibitor, vector and siRNA were employed to validate the regulatory mechanisms of AFAP1-AS1 in the development and progression of NSCLC. Cell proliferation was detected by MTT assay and EdU staining. Cell migration and invasion, and cell cycle and apoptosis were measured by transwell assay and flow cytometry, respectively. Results: A high expression of AFAP1-AS1 was identified in NSCLC, alongside with a reduced level of IL-12 and increased levels of IL-10 and interferon (IFN)-γ. Aberrant expressions of AFAP1-AS1 were associated with pathological grade, TNM staging and metastatic potential of NSCLC. AFAP1-AS1 could activate interferon regulatory factor (IRF)7, the retinoid-inducible protein (RIG)-I-like receptor signaling pathway and Bcl-2 in vitro. Over-expression of AFAP1-AS1 promoted NSCLC cell proliferation, invasion and migration while inhibiting cell apoptosis. Conclusion: lncRNA AFAP1-AS1 promotes migration and invasion of non-small cell lung cancer via up-regulating IRF7 and the RIG-I-like receptor signaling pathway.
The Effect of LncRNA H19/miR-194-5p Axis on the Epithelial-Mesenchymal Transition of Colorectal Adenocarcinoma
Authors: Li Chang-feng , Li Yong-chao  , Wang Yun , Sun Li-bo
Published: October 2018

Background/Aims: Since the combined actions of lncRNAs and miRNAs have been considered to be involved in the occurrence and development of various neoplasms, the main purpose of this study was to discover whether and how lncRNA H19 and miR-194 influenced the epithelial-mesenchymal transition (EMT) process of colorectal adenocarcinoma (CRA). Methods: Totally 214 pairs of CRA and adjacent normal tissues were collected, and 5 human CRA cell lines (i.e. HCT116, HT-29, RKO SW280 and Lovo) were purchased. Quantitative reverse transcription-polymerase chain reaction (qRT-PCR) was adopted to quantify the H19 and miR-194-5p expressions in cells and tissues. The expressions of FoxM1, E-cadherin, vimentin, N-cadherin were determined using western blot. On the side, si-H19, si-NC, miR-194-5p mimic, miR-194-5p inhibitor and negative control (NC) were transfected into CRA cell lines. Meanwhile, the invasive, migratory and proliferative conditions of the cells were assessed through transwell, wound healing and colony-forming experiments, with final verification of the relationship between H19 and miR-194-5p employing dual-luciferase reporter gene assay. Results: Highly-expressed H19, lowly-expressed miR-194-5p, low-grade differentiation and lymph node metastasis appeared as the independent predictors of unfavorable prognosis in CRA patients’ (all P< 0.05). It indicated that FoxM1 expression displayed positive correlations with H19 expression, yet negative associations with miR-194-5p expression within CRA tissues (P< 0.05). In addition, transfection of H19-siRNA and miR-145-5p mimic triggered a conspicuous increase in E-cadherin expression, as well as an evidently down-regulation in vimentin and N-cadherin expressions within HT29 and RKO cells (P< 0.05). On the other hand, the invasive and migratory capacities of CRA cells were significantly hindered (P< 0.05). Moreover, the luciferase reporter gene assay confirmed that H19 modified miR-194-5p expression through directly targeting at it (P< 0.05). Ultimately, FoxM1 could reverse the role of miR-194-5p in inhibiting invasion, migration and EMT of CRA cells (P< 0.05). Conclusion: LncRNA H19/miR-194/FoxM1 axis could serve as a profound target for the diagnosis and treatment of CRA.
Ragtime: breve história, características e principais compositores
Authors: Misina Guilherme Massao , Sulpício Eliana C. M. Guglielmetti
Published: October 2018

O Ragtime foi um gênero musical que surgiu nos EUA por volta dos anos de 1890, tendo seu declínio a partir dos anos de 1910. Teve fortes influências da música africana e de gêneros norte-americanos, a exemplo dos Minstrel Shows, Coon Songs, Cakewalks, dentre outros. Serviu como fonte de inspiração a outros gêneros que ganharam destaque futuramente, como o Jazz e o Blues. O presente artigo apresenta uma breve história do Ragtime, suas principais características e principais compositores.
Education and Politics in Wartime: School Systems in North and South Vietnam, 1965–1975
Authors: Dror Olga
Published: October 2018

From the late 1950s until 1975, the war between North and South Vietnam had both domestic and international consequences. Unlike the Cold War divide between the United States and the Soviet Union, the war between the Democratic Republic of Vietnam (DRV, the Communist North) and the Republic of Vietnam (RVN, the non-Communist South) was an armed conflict between two polities that both identified themselves as Vietnamese. In this twenty-year-long struggle, the fates of the DRV and the RVN were tied to their success in producing new generations who would subscribe to their respective agendas. This was done through many venues, of which education was one of the most important. Relying on archival materials and published documents, this article compares the educational systems at the primary and secondary school levels in the DRV and RVN after the division of the country, with a special focus on the period 1965–1975.
The Hazards of Operations Involving Nuclear Weapons during the Cold War
Authors: Leitenberg Milton
Published: October 2018

This article provides an overview of the perils of U.S. and Soviet nuclear war planning during the Cold War. In particular, the article discusses instances of false alarms, when one side or the other picked up indications of an imminent attack by the other side and had to take measures to determine whether the indicators were accurate. None of these incidents posed a large danger of an accidental nuclear war, but they illustrate the inherent risks of the war preparations that both the United States and the Soviet Union took for their immense nuclear arsenals.
Primary Interoceptive Cortex Activity during Simulated Experiences of the Body
Authors: Wilson-Mendenhall Christine D. , Henriques Alexa , Barsalou Lawrence W. , Barrett Lisa Feldman
Published: October 2018

Studies of the classic exteroceptive sensory systems (e.g., vision, touch) consistently demonstrate that vividly imagining a sensory experience of the world—simulating it—is associated with increased activity in the corresponding primary sensory cortex. We hypothesized, analogously, that simulating internal bodily sensations would be associated with increased neural activity in primary interoceptive cortex. An immersive, language-based mental imagery paradigm was used to test this hypothesis (e.g., imagine your heart pounding during a roller coaster ride, your face drenched in sweat during a workout). During two neuroimaging experiments, participants listened to vividly described situations and imagined “being there” in each scenario. In Study 1, we observed significantly heightened activity in primary interoceptive cortex (of dorsal posterior insula) during imagined experiences involving vivid internal sensations. This effect was specific to interoceptive simulation: It was not observed during a separate affect focus condition in Study 1 nor during an independent Study 2 that did not involve detailed simulation of internal sensations (instead involving simulation of other sensory experiences). These findings underscore the large-scale predictive architecture of the brain and reveal that words can be powerful drivers of bodily experiences.
The Neurodynamic Decision Variable in Human Multi-alternative Perceptual Choice
Authors: Kohl Carmen , Spieser Laure , Forster Bettina , Bestmann Sven , Yarrow Kielan
Published: October 2018

The neural dynamics underpinning binary perceptual decisions and their transformation into actions are well studied, but real-world decisions typically offer more than two response alternatives. How does decision-related evidence accumulation dynamically influence multiple action representations in humans? The heightened conservatism required in multiple compared with binary choice scenarios suggests a mechanism that compensates for increased uncertainty when multiple choices are present by suppressing baseline activity. Here, we tracked action representations using corticospinal excitability during four- and two-choice perceptual decisions and modeled them using a sequential sampling framework. We found that the predictions made by leaky competing accumulator models to accommodate multiple choices (i.e., reduced baseline activity to compensate increased uncertainty) were borne out by dynamic changes in human action representations. This suggests a direct and continuous influence of interacting evidence accumulators, each favoring a different decision alternative, on downstream corticospinal excitability during complex choice.
Testing an agent-based model of language choice on sociolinguistic survey data
Authors: Karjus Andres , Ehala Martin
Published: October 2018

The paper outlines an agent-based model for language choice in multilingual communities and tests its performance on samples of data drawn from a large-scale sociolinguistic survey carried out in Estonia. While previous research in the field of language competition has focused on diachronic applications, utilizing rather abstract models of uniform speakers, we aim to model synchronic language competition among more realistic, data-based agents. We hypothesized that a reasonably parametrized simulation of interactions between agents endowed with interaction principles grounded in sociolinguistic research would give rise to a network structure resembling real-world social networks, and that the distribution of languages used in the model would resemble their actual usage distribution. The simulation was reasonably successful in replicating the real-world scenarios, while further analysis revealed that the model parameters differ in importance between samples. We conclude that such variation should be considered in parametrizing future language choice and competition models.
Names of hydroids (Cnidaria, Hydrozoa) established by Charles McLean Fraser (1872–1946), excluding those from Allan Hancock Expeditions
Authors: CALDER DALE R. , CHOONG HENRY H.C.
Published: October 2018

An account is given of the names of families, genera, and species of hydroids established by C.M. Fraser of Canada, excluding those from Allan Hancock Pacific Expeditions and the Allan Hancock Caribbean Sea Expedition. The names of four families, 11 genera, and 101 species are attributed to him in this work, complementing those of another two genera and 164 species described by Fraser in various Allan Hancock publications. Information is provided on type localities of his new species, on locations and kinds of type material in existence, where known, and on the current taxonomic status of families, genera, and species described by him in works reviewed herein. Two replacement names (Thuiaria geniculata Fraser, 1918a and Salacia fraseri Calder, 1991) exist for Thuiaria distans Fraser, 1914a (not Thuiaria distans Allman, 1877). The widely overlooked senior synonym, T. geniculata, is recognized as the valid name of the species. Diphasia alta nom. nov. is proposed as a new replacement name for the permanently invalid junior primary homonym Diphasia robusta Fraser, 1943a (not D. attenuata robusta Billard, 1924). In addition, Cryptolaria crassa nom. nov. is proposed as a new replacement name for the junior secondary homonym Cryptolaria rigida (Fraser, 1948) [not C. rigida (Fraser, 1940a)]. Lectotypes have been designated for 47 of the species to establish objective standards for application of their names. Corymorpha adventitia Fraser, 1941b, from the Pacific coast of Panama, is assigned to Ralpharia Watson, 1980, as R. adventitia. No type specimens are known to exist for seven of the species considered, including one holotype (of Hebella eximia Fraser, 1944a) missing from its bottle. Particular attention has been paid to dating and chronology of the 51 publications of Fraser covered in this work. Earlier bibliographic errors are corrected, most notably establishing that the book Distribution and relationship in American hydroids was published in early 1947 rather than 1946 as per the title page.
100 Years of Progress in Tropical Cyclone Research
Authors: Emanuel Kerry
Published: October 2018

A century ago, meteorologists regarded tropical cyclones as shallow vortices, extending upward only a few kilometers into the troposphere, and nothing was known about their physics save that convection was somehow involved. As recently as 1938, a major hurricane struck the densely populated northeastern United States with no warning whatsoever, killing hundreds. In the time since the American Meteorological Society was founded, however, tropical cyclone research blossomed into an endeavor of great breadth and depth, encompassing fields ranging from atmospheric and oceanic dynamics to biogeochemistry, and the precision and scope of forecasts and warnings have achieved a level of success that would have been regarded as impossible only a few decades ago. This chapter attempts to document the extraordinary progress in tropical cyclone research over the last century and to suggest some avenues for productive research over the next one.
Winter Storm Conditions Leading to Excessive Runoff above California’s Oroville Dam during January and February 2017
Authors: White Allen B. , Moore Benjamin J. , Gottas Daniel J. , Neiman Paul J.
Published: October 2018

During winter 2016/17, California experienced numerous heavy precipitation events linked to land-falling atmospheric rivers (ARs) that filled reservoirs and ended a severe, multiyear drought. These events also caused floods, mudslides, and debris flows, resulting in major socioeconomic disruptions. During 2–11 February 2017, persistent heavy precipitation in the northern Sierra Nevada culminated in a rapid increase in the water level on Lake Oroville, necessitating the activation of an emergency spillway for the first time since the Oroville Dam was installed and forcing the evacuation of 188,000 people. The precipitation, which mostly fell as rain due to elevated freezing levels, was focused on the western slope of the Sierra Nevada in connection with orographic forcing linked to two successive ARs. Heavy rain fell on saturated soils and a snowpack produced by antecedent storms and thereby resulted in excessive runoff into Lake Oroville that led to a damaged spillway and complicated reservoir operations.
Aerosol Effects on Clouds and Precipitation over Central Europe in Different Weather Regimes
Authors: Barthlott Christian , Hoose Corinna
Published: October 2018

The response of clouds to changes in the aerosol concentration is complex and may differ depending on the cloud type, the aerosol regime, and environmental conditions. In this study, a novel technique is used to systematically modify the environmental conditions in realistic convection-resolving simulations for cases with weak and strong large-scale forcing over central Europe with the Consortium for Small-Scale Modeling (COSMO) model. Besides control runs with quasi-operational settings, initial and boundary temperature profiles are modified with linear increasing temperature increments from 0 to 5 K between 3 and 12 km AGL to represent different amounts of convective available potential energy (CAPE) and relative humidity. The results show a systematic decrease of total precipitation with increasing cloud condensation nuclei (CCN) concentrations for the cases with strong synoptic forcing caused by a suppressed warm-rain process, whereas no systematic aerosol effect is simulated for weak synoptic forcing. The effect of increasing CCN tends to be stronger in the simulations with increased temperatures and lower CAPE. While the large-scale domain-averaged responses to increased CCN are weak, the precipitation forming over mountainous terrain reveals a stronger sensitivity for most of the analyzed cases. Our findings also demonstrate that the role of the warm-rain process is more important for strong than for weak synoptic forcing. The aerosol effect is largest for weakly forced conditions but more predictable for the strongly forced cases. However, more accurate environmental conditions are much more important than accurate aerosol assumptions, especially for weak large-scale forcing.
Algorithm for Flat First-Year Ice Draft Using AMSR2 Data in the Arctic Ocean
Authors: Yoshizawa E. , Shimada K. , Cho K. H.
Published: October 2018

First-year ice has replaced multiyear ice in the Northern Sea Route area since 2008. In this area, sea ice survival during summer substantially depends on first-year ice thickness at melt onset, and thus monitoring of first-year ice thickness in the freezing period is a key to forecasting sea ice distributions in the following summer. In this paper we introduce a new algorithm to estimate flat first-year ice draft using brightness temperature data measured by the Advanced Microwave Scanning Radiometer-2 (AMSR2). The algorithm uses a gradient ratio (GR) of 18- and 36-GHz vertically polarized brightness temperatures based on decreases in sea ice emissivity in higher AMSR2 frequency channels with thermodynamic growth associated with an increase in volume scattering. Such spectral characteristics of the emissivity are examined by comparing GR values with flat first-year ice draft extracted by mode values of in situ draft data measured by a moored ice profiling sonar. The accuracy of the daily draft estimated from GR values after applying proper noise filters is about 10 cm for a draft range of 0.4–1.2 m.
Heavy Rainfall Associated with Double Low-Level Jets over Southern China. Part I: Ensemble-Based Analysis
Authors: Du Yu , Chen Guixing
Published: October 2018

Heavy rainfall occurred at both the inland frontal zone and coastal warm sector in southern China during 10–11 May 2014, which is a typical pattern in the early-summer rainy season. To clarify the key factors controlling the rainfall, we conduct an ensemble-based analysis using the operational global ensemble forecasts from ECMWF. The forecasts of frontal (warm sector) rainfall have a relatively small (large) spread and a small (large) bias of ensemble-mean amount, suggesting an obvious difference in the predictability. It is shown that double low-level jets (LLJs) in the southwesterly moist flow play a significant role in the heavy rainfall over southern China. The inland frontal rainband is closely related to the synoptic-system-related low-level jet (SLLJ) with maximum wind speed at 850–700 hPa, especially for its meridional wind component. The more intense cold front is accompanied by the stronger southwesterly SLLJ on the adjacent south side, favoring more precipitation near the front. The warm-sector heavy rainfall, a few hundred kilometers away from the front, is associated with the boundary layer jet (BLJ) at 925 hPa. The southerly BLJ occurs over the northern region of the South China Sea and reaches its maximum wind speed in the early morning. The variations of the BLJ are mainly induced by the surface low and related upper-level short-wave trough upstream. The large pressure gradient to the southeast of the surface low can accelerate the BLJ by increasing the geostrophic winds. The diurnal cycle of the low-level winds, seen in the climatology, also contributes in part to the development of the BLJ at night.
Public servants, anonymity, and political activity online: bureaucratic neutrality in peril?
Authors: Cooper Christopher A.
Published: October 2018

Various actors have recently expressed concern that by threatening anonymity, social media places the bureaucracy’s neutrality in jeopardy. Yet, empirically, little is known about the online political activities of public servants. Drawing upon the public service motivation literature, this article develops contrasting hypotheses between public sector employment and online political activity. Testing hypotheses with survey data from Canada, the results show that unionized public sector employment reduces the probability of being politically active online. As social media continues to change the nature of governance, the results suggest that anonymity and neutrality remain important professional norms within the Westminster administrative tradition, and are reflected in the online political activities of public sector employees in Canada.

Points for practitioners

• Due to its visibility and permanency, public servants’ political activity on social media potentially threatens their reputation as politically impartial officials. • Some governments and public sector unions have thus voiced messages of caution to administrative personnel about the dangers of being politically active online. • Survey data from Canada suggest that these messages have worked. • Unionized public sector employment reduces the probability of being politically active online but does not reduce the probability of being active in traditional “offline” political activities.
Policy advisory styles in the francophone Belgian civil service
Authors: Aubin David , Brans Marleen
Published: October 2018

In a context of the rising importance of ministerial advisers, this article provides empirical evidence about the nature of involvement of civil servants in policy work. Based on a survey of graduated civil servants in francophone Belgium, it shows that civil servants are much involved in policy work even in a politico-administrative system characterised by strong ministerial cabinets. Belgian francophone civil servants are ‘incidental advisors’. They are less process generalists than issue specialists who mostly deal with policy implementation. Their policy advisory style oscillates between ‘rational technician’ and ‘client advisor’. Despite a low institutionalisation of policy advice in the civil service, civil servants significantly serve the ministers in the policy formulation (for harmonization) phase, supplying information and analysis and participating to the writing of policy-related texts.

Points for practitioners

The francophone Belgian case shows the importance of policy tasks conducted by civil servants. It also provides evidence about the importance of in-house policy-analytical capacity as it shows that civil servants primarily rely on internal information sources and consultation when involved in policy formulation.