bluuebunny/crossref_metadata_2025 huggingface dataset:
Role of Mirena in Dub Patients
Authors: Begum Rokeya , Khanam Mafruha
Published: September 2022

To determine the effectiveness of Mirena in achieving a reduction in heavy menstrual blood loss in dysfunctional uterine bleeding. To evaluate improvement in Haemoglobin level (Hb gm%) in patients during treatment period. The study was conducted in the department of Obstetrics & Gynaecology, Chittagong Medical College Hospital, Chittagong, Bangladesh from August 2008 to July 2010. Thirty six patients with Dysfunctional Uterine Bleeding (DUB) in 30-45 years age group with Body Mass Index (BMI) of 18-30 during treatment period were included in this study. They were counseled, investigated and Levonogestrel Intrauterine device Mirena was inserted. Outcome was measured by the Hb improvement and decrease in blood loss both in amount and duration. Record was kept and follow up was done. Ninety percent of the patients were relived from menorrhagia and one hundred percent improvement was seen in cases with polymenorrhagia. Fifty percent patients had an Hb of >11.1 gm% after 3 months of use. Mirena is a safe and effective device for treatment of DUB patients and it is an alternative to hysterectomy.

JCMCTA 2014 ; 25 (1): 8-11
Labour Outcome in Adolescent Pregnancy
Authors: Nessa Kamrun , Chowdhury Shahanara , Malik Adiba , Ara Sarwat , Chowdhury Zinat Ara , Saleh Adnan Bin
Published: September 2022

Adolescent pregnancy is associated with increased risk of developing complications in both adolescent mother and neonates. It may lead to significant maternal and perinatal mortality and morbidity. To evaluate the labour outcome in adolescent and adult mothers' immediately after delivery and compare the result. A cross sectional comparative study was performed over a period of one year (September 2009- August 2010) at the obstetrics department of Chittagong Medical College Hospital. Consecutive three hundred pregnant mothers admitted for delivery that was fulfilled the inclusion criteria included in study group. Among them 150 were adolescent (13-19yrs) belongs to group A and 150 was adult (20-29 yrs) belongs to group B. Labour outcome (prolonged or obstructed, mode of delivery, stillbirth, birth weight and birth asphyxia were recorded on a preformed questionnaire and statistical analysis done by using SPSS package for windows version 12. Adolescent mother has significant lower mean age at delivery than adults (18.61872 vs. 23.87 = 2.8 yrs. P< 001).Antenatal check up were also (10% vs. 26%, P < 001) infrequent in them. Spontaneous vaginal delivery significantly less (34.7% vs. 48%, P <03) and Caesarean section and instrumental deliveries higher (59.3% vs. 48% & 6% vs. 2.6%.P <03 respectively) in adolescent. Stillbirth and neonatal death also more (3.3% vs. 1.3 & 10% vs. 4.66%, P < 049 respectively) and birth weight less (2.7 kg vs. 2.88 kg, P <0.019) in group A in comparison with group B. Incidence of low birth weight and asphyxia higher in adolescent (12.4% vs. 5.4%, P <03 & 20% vs. 14.9% P<.024). Operative deliveries, stillbirth, birth asphyxia, low birth weight and neonatal death rate significantly higher in adolescent mothers where vaginal delivery significantly less in them in comparison with adult mothers. It indicates that adolescent pregnancy was associated with adverse labour outcome.

JCMCTA 2014 ; 25 (1): 22-26
Prevalence of Modifiable Cardiovascular Risk Factors Among Malaysian Patients With Acute Coronary Syndrome
Authors: Khanom Mehrunnissa , Ahmad Wan Azman Wan
Published: September 2022

The growing epidemic of coronary heart disease in Asian countries can be prevented and controlled by identification and management of potentially modifiable risk factors. This article provides a single centre statistics of major modifiable risk factors among Malaysian patients presenting with acute coronary syndrome (ACS) and gives a brief discussion on preventive strategies. A single centre, prospective, observational, cohort study model was used. The subjects were patients of 18 years old or above who were admitted to University Malaya Medical Centre (UMMC), Malaysia within January 2009 to December 2010 and recruited under national ACS registry. Among 1525 consecutive ACS patients, 93% had at least one modifiable risk factor and nearly 70% had three or more risk factors. Overall, the prevalence of risk factors in descending order were: hypertension (70%), smoking (47%), diabetes (43%), dyslipidaemia (23%) and Body Mass Index (BMI)>24 (17%). Majority of male patients were smokers (67%) and most of the females were hypertensives (77%). Hypertension was the strongest predictor of mortality among all ACS patients (odds ratio 2.42, 95% CI, (1.43-4.10)]. Identification and primordial prevention of these risk factors are mandatory for prevention of coronary heart disease in the population.

JCMCTA 2014 ; 25 (1): 32-36
Primary Orbital Lymphoma: A Rare Presentation of NHL
Authors: Rabbani Mohammad Golam , Islam Ahmed Tanjimul , Chaudhury Shahed Ahmad , Uddin Jasim , Islam Nazrul , Sultana Shamrin
Published: September 2022

Non Hodgkins Lymphoma (NHL) is a malignant neoplasm of lymphoid tissue representing 5% of all malignant tumors and one of the commonest haematological malignancy in our country. The disease can involve in any organ commonly in lymph nodes, liver, spleen, brain, eye, testis, thyroid. Orbital lymphoma is comprised about 1% of all NHL. This is a case report of a patient age of 50 years from Daudkandi, Comilla admitted in Chittagong Medical College Hospital with history of gradual non tender swelling in the left eye with no other organ involvement or any B symptoms. The objective of this study to consider orbital lymphoma as differential diagnosis of orbital swelling as it can occur almost any part of the body and is to minimize the delay of diagnosis as well as to improve prognosis. We analyzed the history, examination, investigations & histopathology and immunohistochemistry of orbital growth that showed Non Hodgkin Lymphoma (Low Grade). The Patient was treated with consecutive six cycle R-CHOP (Rituximab, Cyclophosphamide, Adriamycin, Vincristine, Prednisolone) resulting in complete remission of lymphoma.

JCMCTA 2014 ; 25 (1): 41-43
Ethics in Medical Research
Authors: Yusuf Omar Faruque
Published: September 2022

Abstract not available

JCMCTA 2014 ; 25 (2) : 1-2
The Risk of Malignancy Index (Rmi) In Preoperative Prediction of Malignancy in a Clinically Suspicious Ovarian Mass
Authors: Noor Serajun , Mahmood Sayed , Akhter Shaheda , Jabin Taniza
Published: September 2022

There is no satisfactory preoperative tools to differentiate a benign from malignant masses in pelvis. Serum CAl25 level, pelvic ultrasonogram and menopausal status are used individually to predict malignancy with poor outcome but the use of three in association RMI can improve diagnostic performance. Objective:- To evaluate RMI scoring system as method of choice for predicting whether or not an ovarian mass is likely to be malignant. Design:- Cross sectional study. Settings:- Chittagong medical college hospital and Chittagong metropolitan hospital. Duration: January 2011 to October 2014. Sample size:-175 patients admitted in January 2011 to October 2014. The risk malignancy index was calculated as UXMXCA 125 performed preoperatively. Ultrasound findings were scored depending on wall structure, wall thickness and echogenecity (1,4), Menopausal status pre and post menopausal scored as (1,4) and absolute level of CA 125 measured by radioimmunoassay. The individual performance were found in RMI (sen82%, spe 77%, +ve PV 81%, -vePV23, +veLR5.s6, -veL. 53, accuracy 78%), USG (sen86%, spe23%, +vePV87%, vePV32%, +veLR6.5%, veLR.84, accuracy 82%), CAl25 (sen72%, spe32%, +vePV87%, vePV32%, +veLR6.5, veLR. 84, accuracy 67%), Manupausal status (sen84%, spe50%, +vePV21%, -vePV2.4%, +veLR, -veLR, accuracy78%). The area under the ROC curve for risk malignancy index was (.8-.9), which was greater than the area for CAl25 (.6-.7), USG (.7-.8) score and menopausal status (.7-.8). The risk malignancy index using ultrasound morphological score, serum CAl25 level and menopausal status might be of value in the preoperative assessment of ovarian carcinoma.

JCMCTA 2014 ; 25 (2) : 14-20
Incidence, Risk Factor and Pregnancy Outcome Of Preterm Labour: One Year Study In Combined Military Hospital, Chittagong
Authors: Jannat Farhana , Sultana Mahbuba , Nahar Nargis , Jahan Ishrat
Published: September 2022

Preterm labour & delivery are very challenging obstetric complications encountered by obstetricians. In this study we tried, to determine the incidence, risk factor and pregnancy outcome of patients presenting with preterm labour in Combined Military Hospital. Its a retrospective study in the department of Gynecology & Obstetric, Combined Military Hospital, Chittagong Cantonment from July 2012 to June 2013. Sample size: 116. Inclusion Criteria: Gravid women both primi and multi. Pregnancy of more than 28 weeks duration but less than 37 completed weeks of gestation. Patient is in active labour. Exclusion Criteria: Labour pain started before 28 weeks of pregnancy. Induced preterm labour in any cases like PIH, eclampsia, Preeclampsia, APH, foetal IUGR, etc. Incidence of preterm labour was 22.30% in this study. Preterm rupture of membranes and infection were the commonest causes of preterm labour. Significant risk factor associated with preterm labours in this study are maternal age <20->35 years, low socio-economic condition, lack of proper antenatal care, multiple pregnancy etc. Irrespective of use of a course of steroid neonated mortality was significantly high in babies before 34 weeks. Other perinatal outcomes of preterm labour are birth asphyxia, RDS, neonatal jaundice and septicemia. High incidence of preterm labour being the most serious problem facing our obstetrician. The incidence is higher in our set up, compared to the developed countries. As prevention is naturally best way to combat preterm labour, some modifiable risk factors are identified. Health care provider may encounter maternal age, nutritional status, infection and can identify the target population for betters prenatal care.

JCMCTA 2014 ; 25 (2) : 41-45
Post-cholecystectomy Syndrome Due To Stump-Stones: A Possibility
Authors: Ahmed Jashim Uddin , Alam Kawsar , Uddin Nasir , Hoque Md Nurul , Jabin Taniza
Published: September 2022

Recurrence of biliary symptoms following cholecystectomy either laparotomic or laparoscopic, is quite common. Causes are either biliary or extra-biliary. Symptoms of biliary origin chiefly depends on residual stones, biliary stricture, rarely depends on stones in cystic duct or gallbladder remnant. Diagnosis of stump-stones is difficult, mainly arising from USG, MRCP,CT-scan, ERCP. Completion cholecystectomy can be done by laparotomy or laparoscopically. We report two cases of stump-stones discovered after 10 years & 5 years following lap chole and minilap cholecystectomy respectively, who were diagnosed by USG, CT-scan and managed by open completion cholecystectomy. Stump-stones can be a possibility of post cholecystectomy syndrome even after 10 years and surgeons should be aware of it.

JCMCTA 2014 ; 25 (2) : 49-53
Gastric Duplication Cyst in a Neonate: A Rare Case Report
Authors: Rahman MA Mushfiqur , Bhuiyan Md Akbar Husain , Chowdhury Tanvir K , Sajid Md Minhajuddin
Published: September 2022

Among the duplication cysts of Gastro intestinal tract, Gastric duplication is rarer. Here we are reporting a case of gastric duplication cyst in a neonate.

JCMCTA 2014 ; 25 (2) : 57-60
PENINGKATAN KEMAMPUAN PENALARAN STATISTIS MAHASISWA MELALUI PEMBELAJARAN BERBASIS PROYEK BERBANTUAN ICT
Authors: La Nani Karman
Published: September 2022

Masalah penelitian ini adalah rendahnya kemampuan penalaran statistis (KPS) mahasiswa. Penelitian ini bertujuan untuk mengetahui pencapaian dan peningkatan KPS mahasiswa melalui pembelajaran berbasis proyek berbantuan ICT (PBP berbantuan ICT). Penelitian ini berbentuk quasi eksperimen dengan desain kelompok kontrol pretes-postes. Jumlah sampel penelitian ini sebanyak 51 mahasiswa yang diambil secara purposive sampling dari 102 mahasiswa yang mengikuti perkuliahan pengantar statistika. Penelitian ini mempunyai dua variabel, yaitu: penerapan pembelajaran berbasis proyek berbantuan ICT sebagai variabel bebas dan kemampuan penalaran statistis mahasiswa sebagai variabel tak bebas. Instrumen yang digunakan untuk pengumpulan data adalah instrumen tes KPS berjumlah 6 butir soal berbentuk essay. Data yang diperoleh dianalisis secara deskriptif dan inferensial. Analisis deskriptif, meliputi: deskripsi pencapaian dan peningkatan KPS mahasiswa. Analisis inferensial adalah menggunakan statistik uji Mann-Whitney U. Hasil penelitian menunjukkan bahwa pencapaian dan peningkatan KPS mahasiswa yang memperoleh PBP berbantuan ICT lebih baik dibandingkan yang memperoleh pembelajaran konvensional (PK). Pencapaian KPS mahasiswa yang memperoleh PBP berbantuan ICT dalam kategori baik sedangkan yang memperoleh PK dalam kategori cukup. Peningkatan KPS mahasiswa yang memperoleh PBP berbantuan ICT tergolong tinggi dan yang memperoleh PK tergolong sedang. Terdapat perbedaan yang signifikan pencapaian dan peningkatan kemampuan penalaran statistis mahasiswa antara yang memperoleh PBP Berbantuan ICT dan yang memperoleh PK. Signifikansi perbedaan tersebut dapat disimpulkan bahwa penerapan PBP berbantuan ICT dapat meningkatan kemampuan penalaran statistis mahasiswa.
PENGEMBANGAN BAHAN AJAR TEMATIK TERPADU BERBASIS PROBLEM BASED LEARNING UNTUK MENINGKATKAN KEMAMPUAN BERPIKIR KRITIS SISWA SD KELAS V
Authors: Rahman Mardia Hi. , Latif Saiful
Published: September 2022

The 2013 curriculum suggests that learning must be integrated or commonly known as integrated thematic learning. Thematic learning in elementary schools usually combines material on several subjects into one theme. The references used by both teachers and students are provided by the government, namely teachers’ book and students’ book. The teachers directly teach their students using references provided without analyzing or further developing by the teacher. The implementation of 2013 curriculum requires teachers to be creative in using various learning models and scientific approaches. With these demands the teacher should be able to develop teaching materials in accordance with the learning model. This research is motivated by the importance of developing integrated thematic teaching materials based on Problem Based Learning models that are able to improve the critical thinking skills of fifth grade students. The study was conducted for 3 months. This type of research is development research refers to the 4-D model proposed by Thiagarajan, but this research is limited to defining, designing and developing. The instrument used to assess the quality of teaching materials is a questionnaire with five categories, while students' critical thinking skills use test instrument. Data analysis was performed by descriptive analysis. The results of the analysis show that integrated thematic teaching materials based on Problem Based Learning (PBL) on heat and its transfer are stated to meet valid criteria and practicality, because teaching materials are developed based on supporting theories consistently and can be used easily. Whereas in the effectiveness test of integrated thematic teaching materials based on problem based learning, it was declared effective to be used because the developed teaching materials had a positive impact in increasing students' critical thinking skills.
LANGUAGE AS A SOCIAL INSTRUMENT
Authors: Usman Abdurrahman Hi. , Mahmud Adi F. , Daud Abdulhalim , Dahlan Suratman
Published: September 2022

The study focuses on the usefulness and the use of language as an instrument to associate a group of people in the society, both in the large and in the small groups to fulfill their everyday needs. They were described in the form of ideas and arguments that were investigated in the form of activities of library research design. The data were collected from many references both primary and secondary ones in terms of the topic. The primary data dealt with the roles and functions of language in terms of the usefulness and the usage of language in society. The findings of the study showed that language is used as an important instrument to connect people in many aspects of human life consisting of language in the world of education, language in the world of science and technology, language in economic and business contexts, language in the social and political contexts, language in the aspects of national defense and security, language and international relation.
The Recommendation of the Methods to Evaluate the Nasal Valve Problem in the Consideration of Nasal Valve Reconstruction
Authors: Hwang Se Hwan , Kim Soo Whan
Published: September 2022

Nasal valve compromise (NVC) is a common source of nasal airway obstruction, with multiple effective methods for correction. However, there has been the absence of a gold standard test to diagnose the specific source of NVC. Currently, history and physical exam are key measures for distinguishing the NVC from the other anatomical abnormalities. However, there remain ambiguities and disparities in the clinically effectiveness regarding the nasal endoscopy, physiologic measurements (acoustic rhinometry and rhinomanometry), and anatomical measurement (CT). Ideally, an objective preoperative test would be able to determine the cause for NVC and therefore guide the patient specific surgical strategy. The aim of this study was to make a clinical recommendation to solve these issues in the diagnosis of NVC and we review the methods concerning the various diagnostic tools and NVC.
How to Adjust the Thickness of the Spreader Graft in Nasal Valve Collapse
Authors: Kim Young Nam , Lee Jong Gyu , Lee Ju Yeob , Cho Kyoung Rai
Published: September 2022

Nasal valve collapse is one of the causes of nasal obstruction and must be considered in patients with nasal obstruction. There are several surgical procedures available to treat nasal valve collapse. Spreader grafts can be used in the treatment of nasal valve collapse by widening the internal nasal valve angle and maintaining the widened angle. However, this procedure requires sufficient amount of cartilage harvested from the nasal septum. Especially, in cases of secondary rhinoplasty or some primary nasal surgery with thin septal cartilage, it is difficult to harvest an appropriate amount of cartilage from the septum. Here, we describe an effective technique for using septal cartilage and TnR Nasal Mesh® (T&R Biofab Co., Ltd) for spreader grafts with appropriate thickness in nasal valve collapse.
Education and economic growth variations: Implications for post COVID-19 sustainable development recovery strategy in low-income countries
Authors: Matashu Martha
Published: September 2022

No country is like any other, therefore it is vital to ascertain factors explaining the differences in education and economic growth among and within the low-income countries. The main question is why are there variations in countries? The answers to this question has the potential to provide insights for designing and implementing post Corona virus infectious disease-19 (COVID-19) recovery strategies aimed at promoting inclusive sustainable development. Prior COVID-19 Sub Saharan Africa region contained the largest number of low income countries with low economic growth and lower access to education. An understanding of factors that explain the variations that existed before the COVID-19 should be considered developing recovering strategies. The study used a panel data summary statistics of education and economic growth dataset from the year 2000 to 2018 from 15 low income countries in Sub Saharan African to examine factors that explain the variations in education and economic growth patterns in those countries. The findings reflected that within individual countries rather than between countries variations explain the differences in education and economic growth. The findings led to the conclusion that education and economic growth variation trends observed in Sub Saharan Africa for the past 19 years are explained by variations overtime and not by time invariant factors between countries. Drawing on the observed trends overtime the implications for post COVID-19 sustainable development recovery strategy formulation are presented in this study.
Comparative Analysis of Literature and Narratives Regarding Teaching Practices in Low SES School Districts
Authors: Azzarello Caterina Belle , Bergstrom Cassendra
Published: September 2022

The purpose of this research is to shed light on the educational disparities that exist within the US regarding socioeconomic status (SES). An in-depth interview was performed with a teacher who teaches in a majority high SES school setting and compared with an interview with a teacher who teaches in a majority low SES school setting. Combining literature and narratives, I provide an overview of the pertinent issues related to SES and schools and urge continued research on this topic. Results found three distinct areas of difference: availability of resources, emotional and behavioural health, and COVID-19 response. Educational experiences should not have to vary based on socioeconomic status, and as we strive for equitable education, we ought to continue research such as this.
CHANGES IN THE INSTALLATION METHOD FOR SEGMENTAL ON-SITE STEEL STRUCTURES (ERECTION) TO LIFTING CENTER SPANS ON YOUTEFA BRIDGE (HOLTEKAMP)
Authors:   Atma Jaya Catholic University of Indonesia, Indonesia, Parulian Munthe Saut , Iskandar Isdaryanto ,   Atma Jaya Catholic University of Indonesia, Indonesia
Published: September 2022

This study aimed to determine the appropriate method for the implementation of structural steelwork at the Youtefa Bridge Construction in terms of execution time, work risk, and quality of work. This type of research was field research with a qualitative descriptive method, located on the Youtefa Bridge over Youtefa Bay which connects Jayapura City, Hamadi Village, and Muara Tami District, Papua Island. Data collection conducted by collecting supported data related to the implementation of the Youtefa Bridge, then analyzed on the implementation time, work risks, and the right quality of work to be applied in the Youtefa Bridge Construction. This study showed that the on-site method had not been fully implemented in the field. This is due to the high risk of construction, the assembly duration which takes at least two years, and the threat to the mangrove ecosystem around Youtefa Bay. Based on the method analysis, known that the right method for the Youtefa Bridge work is using the Lifting method. The Lifting method will ensure the safety of the work because the welding process is not carried out at a height. The quality of the steel frame installation is higher because all welding operations are performed in a factory whose quality is more tested when compared to the results of welding in the field, and the work execution time is shortened by 6 months and is faster than when performed on site.
TSHR-AB ELISA KIT: A NOVEL DIAGNOSTIC KIT FOR HASHIMOTO’S AND GRAVES’ DISEASE PATIENTS
Authors:   Al-Farabi university college, Al-Dora, Baghadad, Iraq, A. Khalaf Zena , Sabah Altaiee Marwah ,   Usul Aldeen university college, Iraq
Published: September 2022

Background: one of the global public health problem is Thyroid gland disease. More studies are still required to investigate novel markers to specify the prognosis and recovery of the thyroid gland after both internal and external radiation exposure. Methodology: ELISA was used to quantitatively identify the serum level of TSHR-Ab in human blood specimens of Hashimoto’s and Graves’ disease and normal healthy controls. Results: Increased levels of TSHR-Ab (P<0.01) were observed in Graves' disease patients in comparison to the normal healthy controls, it raising significantly (P < 0.01) after one year of curing with anti-thyroid drugs. In contrast, low levels of TSHR-Ab were observed in Hashimoto’s disease cases, and it decreased significantly (P < 0.01) after treatment. Conclusion: serum TSHR-Ab levels in hyperthyroidism and Hypothyroidism patients might be an effective diagnostic marker that increases the immunological response of T cell and immune system, and optimize the chance for detection and remission of autoimmune thyroid disorder
A REVIEW OF CONVENTIONS, PROTOCOLS, AND AGREEMENTS: IMPORTANCE OF SUSTAINABLE MINING IN ACHIEVING SUSTAINABLE DEVELOPMENT GOALS
Authors:   IIT (ISM), Dhanbad, Jharkhand, India, Sakinala Vikram , Fissha Yewuhalashet ,   Geotechnology and material engineering, Akita University, Japan
Published: September 2022

A set of global objectives for equitable and sustainable health at every scale, from the global biosphere to the local community, are known as the Sustainable Development Goals (SDGs). The goal is to eradicate poverty, save the environment, and guarantee that everyone lives in peace and prosperity both now and in the future. Minerals are necessary for human health and are used in almost every economic sector. Minerals are essential for the general running of the world; one cannot imagine the world without minerals and mining is solely liable for 4 to 7 per cent of greenhouse gas (GHG) emissions. Mining activities can also contribute to longterm development, especially in economics. It can help a country generate cash, fuel economic growth, create jobs, and contribute to infrastructure development. As a result, Mining has positive and negative implications for the SDGs, with 11 of the 17 SDGs having exceptionally high impacts. This paper reviews the Conventions, Protocols, and Agreements and importance of Sustainable Mining in achieving SDGs.
ON- FIELD WATER MANAGEMENT OF GOLDA SMALL SCALE IRRIGATION SCHEME: THE CASE OF ASSOSA, NORTH-WEST OF ETHIOPIA
Authors:   Ethiopian Institute of Agricultural Research, Fentahun Moges Miniebel
Published: September 2022

Miss management of available water for irrigation, both at system and farm level has led to a range of problems and further aggravated water availability and has reduced the benefits of irrigation investments. To solve irrigation water management problem; appropriate irrigation scheduling practices could lead to increased yields and greater profit for farmers, significant water savings, reduced environmental impacts of irrigation and improved sustainability of irrigated agriculture. This study was conducted for evaluating on-field water management of Golda small scale irrigation scheme which is found at Assosa, North- west of Ethiopia. In this study both secondary and primary data sources were used. Soil samples were collected for the determination of soil moisture, field capacity, and permanent wilting point, soil pH, organic matter content, total nitrogen and available phosphorous. Infiltration rate of the soil, crop water requirement, irrigation requirement and irrigation scheduling were determined. Application efficiency, storage efficiency and distribution uniformity of the system was evaluated. The organic matter content and available phosphorous of the soil were lowbut total nitrogen was high. Farmers were applying the same irrigation interval in each growth stage of the irrigated crop but crops are required different amount of water at different irrigation interval within each growth stage. The Application efficiency, storage efficiency and distribution uniformity were determined and the values were 51.6%, 91.6% and 80.76% respectively. Generally, irrigation users did not have sense of ownership for the scheme; poor irrigation water management was a problem as I have observed.
AUTOMATED FLOW INJECTION SPECTROPHOTOMETRIC DETERMINATION OF THE PROTON PUMP INHIBITOR OMEPRAZOLE IN PHARMACEUTICAL FORMULATIONS
Authors:   The Chinese University Hong Kong, Vishwanatth Prof Dr. Kannan
Published: September 2022

A simple and fast flow-injection method for the determination of omeprazole in pharmaceutical preparations is proposed. Detection of the drug is based on the measurement of the absorption signals for the product resulting from the oxidation of omeprazole with N-bromosuccinimide in acidic medium. A flow rate of 0.5 ml/min was pumped and active material was detected at 370 nm. Limit of detection (LOD) and limit of quantitation (LOQ) were calculated to be 2.0 and 6.5 μg/ml, respectively. No interference was observed from common pharmaceutical additives. The method was successfully applied to the assay of omeprazole in capsule preparations and in spiked human plasma. The results were statistically compared with those of the official high-performance liquid chromatography (HPLC) method of the USP by applying Student’s t-test and F-test.
DATA SECURITY IN HEALTHCARE USING IOT
Authors: J G Krithick , T S Nivedh , Bharath S Siva ,   Amrita College of engineering & technology, nagercoil, A. S Dr. Radhamani , Ramanathan V. ,   Amrita College of engineering & technology, nagercoil
Published: September 2022

While the Internet of Things (IoT) has been instrumental in healthcare data transmission, it also presents vulnerabilities and security risks to patients’ personalized health information for remote medical treatment. Currently most published security solutions available for healthcare data don't seem to be focused on data flow all the way from IoT sensor devices placed on a patient’s body through network routers to doctor’s offices. In this project, the IoT network facilitates healthcare data transmission for remote medical treatment, explored security risks related to unsecured data transmission, especially between IoT sensor devices and network routers, then proposed an encrypted security solution initiated at IoT sensor devices. Our proposed solution provides a cryptography algorithm embedded into the sensor device such that packets generated with patient’s health data are encrypted right at the sensor device before being transmitted. The proof of concept has been verified employing a lab setup with two level encryption at the IoT sensor level and two level decryption at the receiving end at the doctor’s office. Test results are promising for an end to-end security solution of healthcare data transmission in IoT. This project also provides further research avenues on IoT sensor driven security.
HASHING & DOUBLE ENCRYPTION TECHNIQUE FOR INFORMATION STORAGE IN CLOUD
Authors: Kumar S Soorya , P Meenakshi ,   SRC-sastra deemed university, Subramanyan A ,   Incedo Tech solutions
Published: September 2022

—Information storage in the cloud is very popular in recent days. The Cloud platform provides various services to its users and one of the important zones of service is the security of the information stored. This project proposes an enhanced approach of a complex Hybrid encryption system involving a Symmetric and an Asymmetric key encryption technique to secure the information on the cloud platform from potential attacks like encryption failure, man-in-middle attack and Insider attack etc along with a hashing technique for the key. The proposed hybrid encryption system involves a newly designed Symmetric key technique "Dehex Algorithm" which encrypts the information with a random key generated from the input size. The Dehex algorithm is followed by the ECC algorithm which is an Asymmetric encryption method. The output formed will be double encrypted information, which then reaches the cloud storage. The keys used for encryption need to be securely stored and so the keys are subjected to the SHA hashing algorithm. Hence this new approach can be one of the ways which can be used for securing information stored in the cloud.
ARTIFICIAL INTELLIGENCE AND ITS UTILIZATION IN HR AND BUSINESS ANALYTICS
Authors:   SASTRA University, Thanjavur,Tamilnadu,India, L Ramyalakshmi , P Girish ,   Jain University, Bangalore, Karnataka, India
Published: September 2022

Analytics have been employed by companies for several decades, but now many firms are interested in building their capabilities for artificial intelligence (AI) as well. Many AI systems, however, are based on statistics and other forms of analytics. Companies can get a “running start” on AI by building upon their analytical competencies. In the last few years, all companies have been interested in the analysis of data related to Human Resources and have focused on human capital, which is considered the major factor influencing the company’s development and all its activities at all levels of human resource policies. Data analysis (HR analytics) will significantly improve business profitability over the next years. We started with an extensive survey of different human resources problems and risks reported by HR specialists, then a comprehensive review of recent research efforts on computer science techniques proposed to solve these problems, and finally focused on suggested artificial intelligence methods. This review article will be an archive and a reference for computer scientists working on HR by summarizing the IT solutions already made in human resources for the period between 2008 and 2018. It aims to present the issues that HR researchers face and for which computer scientists seek solutions. It summarizes at the same time the recent and different methods, IT approaches, and tools already used by highlighting those using artificial intelligence. AI also provides the HR department with an opportunity to improve the candidate and employee experience by automating repetitive, lowvalue tasks and freeing up the time to focus on more strategic, creative work.
AN EFFICIENT FRIENDLY PROCESS FOR SYNTHESIS OF (2E, 6E)-2, 6-BIS (4-NITROBENZYLIDENE) CYCLOHEXANONE A DRUG AGAINST DORMANT VERSION OF THE MYCOBACTERIUM TUBERCULOSIS H37RA
Authors: Vishwanatth Dr Kannan
Published: September 2022

The objective of this study is the Synthesis of (2E, 6E)-2, 6-bis(4-nitrobenzylidene) cyclohexanone a drug against dormant version of the Mycobacterium tuberculosis H37Ra. The Cross-aldol condensation between 4-nitrobenzaldehyde and cyclopentanone catalyzed by modified fluorapatite Na/FAP catalyst in aqueous media is an important protocol for the synthesis of this product and the reaction conditions were optimized by the response surface methodology. The work-up procedure is simplified by simple filtration with high yield and by-products of usual undesirable reaction are not observed.
Fishbowl Colonialism: The White Colonial Gaze on the Sound of Black America in Education
Authors: Cunningham Maya
Published: September 2022

To counter anti-Black racism in the current post-civil rights movement era and to serve the needs of African American students whose cultural experiences have been historically marginalized in U.S. education (Mustaffa, 2017), schools and school systems should strive to provide culturally responsive and sustaining curricula (Paris & Alim, 2017; Ladson-Billings, 1995, 2014). However, when attempts have been made to practice cultural responsivity in English language arts and music education, the result has been an alarming and emotionally charged public backlash (Smitherman, 2006). This article explains this backlash and the resistance to Black sound culture in the classroom by exploring the colonial gaze (Kaplan, 1997) on the Black auditory body. I call this phenomenon "fishbowl colonialism," which describes how Black American music and language are exploited for entertainment but historically have not been considered worthy of serious study or inclusion in formal education. My aim in this essay is to historicize the stigmatization and subalternity of Black sound culture (Keyes, 2003) and to analyze how this stigma hinders efforts to provide culturally responsive education for African American students. If those who shape educational policy and curricula understand how the fishbowl colonialism of Black sound culture influences education policies, African American language (AAL) and music can be reframed in the classroom as a culturally responsive practice that centers on the culture of Black students.
Application of an improved Discrete Salp Swarm Algorithm to the wireless rechargeable sensor network problem
Authors: Yi Zhang , Yangkun Zhou , Hongda Yu , Hong Wang
Published: September 2022

This paper presents an improved Discrete Salp Swarm Algorithm based on the Ant Colony System (DSSACS). Firstly, we use the Ant Colony System (ACS) to optimize the initialization of the salp colony and discretize the algorithm, then use the crossover operator and mutation operator to simulate the foraging behavior of the followers in the salp colony. We tested DSSACS with several algorithms on the TSP dataset. For TSP files of different sizes, the error of DSSACS is generally between 0.78% and 2.95%, while other algorithms are generally higher than 2.03%, or even 6.43%. The experiments show that our algorithm has a faster convergence speed, better positive feedback mechanism, and higher accuracy. We also apply the new algorithm for the Wireless rechargeable sensor network (WRSN) problem. For the selection of the optimal path, the path selected by DSSACS is always about 20% shorter than the path selected by ACS. Results show that DSSACS has obvious advantages over other algorithms in MCV’s multi-path planning and saves more time and economic cost than other swarm intelligence algorithms in the wireless rechargeable sensor network.
Multiomic analysis revealed the regulatory role of the KRT14 gene in eggshell quality
Authors: Wu Yan , Sun Yanyan , Zhang Hao , Xiao Hongwei , Pan Ailuan , Shen Jie , Pu Yuejin , Liang Zhenhua , Du Jinping , Pi Jinsong
Published: September 2022

Background: Eggshell strength and thickness are critical factors in reducing the egg breaking rate and preventing economic losses. The calcite biomineralization process is very important for eggshell quality. Therefore, we employed transcriptional sequencing and proteomics to investigate the differences between the uteruses of laying hens with high- and low-breaking-strength shells.

Results: A total of 1,028 differentially expressed genes (DEGs) and 270 differentially expressed proteins (DEPs) were identified. The analysis results of GO terms and KEGG pathways showed that most of the DEGs and DEPs were enriched in vital pathways related to processes such as calcium metabolism, hormone and amino acid biosynthesis, and cell proliferation and apoptosis. Several DEGs and DEPs that were coexpressed at mRNA and protein levels were verified. KRT14 (keratin-14) is a candidate gene (protein) obtained by multiple omics analysis due to the fold difference of KRT14 being the largest. After the overexpression of KRT14 in uterine epithelial cells, the expressions of OC116 (ovocleididin-116), CALB1 (calbindin 1), and BST1 (ADP-ribosyl cyclase 2) were found to be increased significantly, while the expression of OC17 (ovocleididin-17) was found to be decreased significantly.

Conclusion: In summary, this study confirms that during normal calcification, there are differences in ion transport between the uterus of hens producing high-breaking-strength eggshells and those producing low-breaking-strength eggshells, which may help elucidate the eggshell calcification process. The KRT14 gene may promote calcium metabolism and deposition of calcium carbonate in eggshells.
Keratinocyte-associated protein 3 plays a role in body weight and adiposity with differential effects in males and females
Authors: Szalanczy Alexandria M. , Goff Emily , Seshie Osborne , Deal Aaron , Grzybowski Michael , Klotz Jason , Chuang Key Chia-Chi , Geurts Aron M. , Solberg Woods Leah C.
Published: September 2022

Despite the obesity crisis in the United States, the underlying genetics are poorly understood. Our lab previously identified Keratinocyte-associated protein 3, Krtcap3, as a candidate gene for adiposity through a genome-wide association study in outbred rats, where increased liver expression of Krtcap3 correlated with decreased fat mass. Here we seek to confirm that Krtcap3 expression affects adiposity traits. To do so, we developed an in vivo whole-body Krtcap3 knock-out (KO) rat model. Wild-type (WT) and KO rats were placed onto a high-fat (HFD) or low-fat diet (LFD) at 6 weeks of age and were maintained on diet for 13 weeks, followed by assessments of metabolic health. We hypothesized that Krtcap3-KO rats will have increased adiposity and a worsened metabolic phenotype relative to WT. We found that KO male and female rats have significantly increased body weight versus WT, with the largest effect in females on a HFD. KO females also ate more and had greater adiposity, but were more insulin sensitive than WT regardless of diet condition. Although KO males weighed more than WT under both diet conditions, there were no differences in eating behavior or fat mass. Interestingly, KO males on a HFD were more insulin resistant than WT. This study confirms that Krtcap3 plays a role in body weight regulation and demonstrates genotype- and sex-specific effects on food intake, adiposity, and insulin sensitivity. Future studies will seek to better understand these sex differences, the role of diet, and establish a mechanism for Krtcap3 in obesity.
Potential role of HTLV-1 Tax-specific cytotoxic t lymphocytes expressing a unique t-cell receptor to promote inflammation of the central nervous system in myelopathy associated with HTLV-1
Authors: Tanaka Yukie , Sato Tomoo , Yagishita Naoko , Yamauchi Junji , Araya Natsumi , Aratani Satoko , Takahashi Katsunori , Kunitomo Yasuo , Nagasaka Misako , Kanda Yoshinobu , Uchimaru Kaoru , Morio Tomohiro , Yamano Yoshihisa
Published: September 2022

Human T-lymphotropic virus 1 (HTLV-1) infection causes two serious diseases: adult T-cell leukemia/lymphoma (ATL) and HTLV-1-associated myelopathy (HAM). Immunological studies have revealed that HTLV-1 Tax-specific CD8+cytotoxic T-cells (Tax-CTLs) in asymptomatic carriers (ACs) and ATL patients play an important role in the elimination of HTLV-1-infected host cells, whereas Tax-CTLs in HAM patients trigger an excessive immune response against HTLV-1-infected host cells infiltrating the central nervous system (CNS), leading to local inflammation. Our previous evaluation of HTLV-1 Tax301-309(SFHSLHLLF)-specific Tax-CTLs (Tax301-309-CTLs) revealed that a unique T-cell receptor (TCR) containing amino acid (AA)-sequence motif PDR, was shared among HLA-A*24:02+ACs and ATL patients and behaved as an eliminator by strong activity against HTLV-1. However, it remains unclear whether PDR+Tax301-309-CTLs also exist in HLA-A*24:02+HAM patients and are involved in the pathogenesis of HAM. In the present study, by high-throughput TCR repertoire analysis technology, we revealed TCR repertoires of Tax301-309-CTLs in peripheral blood (PB) of HLA-A*24:02+HAM patients were skewed, and a unique TCR-motif PDR was conserved in HAM patients (10 of 11 cases). The remaining case dominantly expressed (-DR, P-R, and PD-), which differed by one AA from PDR. Overall, TCRs with unique AA-sequence motifs PDR, or (-DR, P-R, and PD-) accounted for a total of 0.3-98.1% of Tax301-309-CTLs repertoires of HLA-A*24:02+HAM patients. Moreover, TCR repertoire analysis of T-cells in the cerebrospinal fluid (CSF) from four HAM patients demonstrated the possibility that PDR+Tax301-309-CTLs and (-DR, P-R, and PD-)+Tax301-309-CTLs efficiently migrated and accumulated in the CSF of HAM patients fostering increased inflammation, although we observed no clear significant correlation between the frequencies of them in PB and the levels of CSF neopterin, a known disease activity biomarker of HAM. Furthermore, to better understand the potential function of PDR+Tax301-309-CTLs, we performed immune profiling by single-cell RNA-sequencing of Tax301-309-CTLs, and the result showed that PDR+Tax301-309-CTLs up-regulated the gene expression of natural killer cell markerKLRB1(CD161), which may be associated with T-cell activation and highly cytotoxic potential of memory T-cells. These findings indicated that unique and shared PDR+Tax301-309-CTLs have a potential role in promoting local inflammation within the CNS of HAM patients.
Case report: Novel use of the conventional method- chemical nail avulsion may be effective for treatment of green nail syndrome
Authors: Yu Qian , Wang Yuanyuan , Yang Hong , Li Wei , Yang Lianjuan
Published: September 2022

Green nail syndrome (GNS) is a triad of green discoloration of the nail plate, proximal paronychia, and distal onycholysis. Pseudomonas aeruginosa is known to be the most common causative agent; however, there is no unified standard for the diagnosis and treatment of GNS. Thus, treatment is challenging and often refractory. Here, we report three representative cases with different predisposing factors, including trauma-related, occupation-related, and onychosis-related GNS. Patients with GNS accompanied by onycholysis were instructed to undergo chemical nail avulsion combined with topical antibiotics, and favorable curative effects were observed in all cases. Chemical nail avulsion with urea powder as a conventional method may be an effective treatment for GNS and warrants clinical generalization.
Longitudinal analysis of exposure to a low concentration of oxytetracycline on the zebrafish gut microbiome
Authors: Kayani Masood ur Rehman , Yu Kan , Qiu Yushu , Yu Xiaogang , Chen Lei , Huang Lisu
Published: September 2022

Oxytetracycline, a widely produced and administered antibiotic, is uncontrollably released in low concentrations in various types of environments. However, the impact of exposure to such low concentrations of antibiotics on the host remains poorly understood. In this study, we exposed zebrafish to a low concentration (5,000 ng/L) of oxytetracycline for 1 month, collected samples longitudinally (Baseline, and Days 3, 6, 9, 12, 24, and 30), and elucidated the impact of exposure on microbial composition, antibiotic resistance genes, mobile genetic elements, and phospholipid metabolism pathway through comparison of the sequenced data with respective sequence databases. We identified Pseudomonas aeruginosa, a well-known pathogen, to be significantly positively associated with the duration of oxytetracycline exposure (Adjusted P = 5.829e−03). Several tetracycline resistance genes (e.g., tetE) not only showed significantly higher abundance in the exposed samples but were also positively associated with the duration of exposure (Adjusted P = 1.114e−02). Furthermore, in the exposed group, the relative abundance of genes involved in phospholipid metabolism had also decreased. Lastly, we characterized the impact of exposure on zebrafish intestinal structure and found that the goblet cell counts were decreased (~82%) after exposure. Overall, our results show that a low concentration of oxytetracycline can increase the abundance of pathogenic bacteria and lower the abundance of key metabolic pathways in the zebrafish gut microbiome that can render them prone to bacterial infections and health-associated complications.