bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison between Simple and Classical Techniques to Create Closed Pneumoperitoneum
Authors: Gharti B. B. , Shrestha P. M. , Shrestha A. , Basnet R. B. , Shah C. , Adhikari B.
Published: November 2022

Background Closed method of pneumoperitoneum using Veress needle is an established technique. Classical closed technique is popular. Simple technique is a modified closed technique.

Objective To compare the classical and simple techniques of closed pneumoperitoneum.

Method This study was conducted in the department of urology, Bir hospital from August 1st 2019 to March 30th 2021. Total 114 patients were randomized into simple and classical technique of creating closed pneumoperitoneum. Time taken for creation of pneumoperitoneum, complications and failure of creating pneumoperitoneum in each group noted and analyzed. Chi square test, Fischer exact test and student t test were used and p < 0.05 considered significant.

Result Among 114 patients, 61 in simple and 53 in classical technique allocated. In simple technique, mean age was 42.98±18.21 years, BMI was 21.84±2.57 kg/m2, mean time for pneumoperitoneum creation was 108.07±21.14 seconds. In classical technique, mean age was 40.15±17.58 years, BMI was 21.94±2.54 (kg/m2), mean time for pneumoperitoneum creation was 189.70±32.21 seconds. Mean time was less in simple technique than classical technique (p < 0.001). Complication rate observed was 6% in each technique (p=0.797) with cumulative rate of 10%. Omental injury was seen in 3.2% in simple technique and 5.6% in classical technique (p=0.662). Retroperitoneal insufflation was seen in 6.5% in simple technique and 5.6% in classical technique (p=0.842). No failed pneumoperitoneum was observed in both groups.

Conclusion Simple technique is as effective, reproducible and safe method as classical technique of creating closed pneumoperitoneum.
Analysis of Prognostic Factors of Bell’s Palsy in a Tertiary Care Centre of Eastern Nepal
Authors: Paudel D. , Chettri S. T. , Sah B. P. , Dahal R. , Pyakurel P.
Published: November 2022

Background Bell’s palsy is the most common cause of acute facial peripheral neuropathy commonly encountered in otolaryngology clinics. Studies regarding epidemiology, risk factors, treatment and prognosis of Bell’s palsy are sparse in our settings.
Objective To analyze the prognostic factors of Bell’s palsy in tertiary care Centre of eastern Nepal.
Method A retrospective chart review of patients diagnosed with Bell’s palsy from 1st January 2005 to 31st December 2018 was done. Records of the patients were obtained from medical record section of BP Koirala Institute of Health Sciences.
Result A Total of 208 patients were included for analysis. After six months 72.6% patients had complete recovery. Patients who presented with lower House Brackmann (HB) grade had significantly better complete recovery than those with high grade (89.1% vs 45.6%). The complete recovery was 80.3%, 73.8%, 63.5% and 50% for the patients of more than 30 yrs, 31-45 years, 46-60 years and more than 60 years respectively and the difference was significant (p= 0.012). Alcohol significantly reduced the complete recovery (p= 0.043). Multivariate analysis showed high HB grade score at presentation to be significant predictor of poor prognosis. (p= 0.001 odds ratio 11.262).
Conclusion Old age, use of alcohol and the severity of facial nerve palsy at the time of presentation were the bad prognostic factors, severity of the palsy was found to be most significant predictor.
Lipid Profile and Ultrasonographic Grading in Alcoholic and Non Alcoholic Fatty Liver Patients
Authors: Shahi A. , Gautam N. , Rawal S. , Sharma U. , Jayan A.
Published: November 2022

Background Fatty liver disease (FLD) is a common and major chronic liver disease. It has been implicated that patients have disorders of lipid metabolism and are involved in the pathogenesis of fatty liver. Hence, it was designed to observe the association between lipid profile and fatty liver disease.

Objective This study was undertaken to evaluate the association of lipid profile status, hemoglobin and albumin levels with fatty liver disease patients diagnosed based on ultrasonography (USG).

Method This Cross-sectional study was undertaken in the Department of Internal Medicine with the collaboration of the Department of Radiology and Department of Biochemistry, Universal College of Medical Sciences-Teaching Hospital (UCMS-TH), Bhairahawa, Nepal from March 2019 to February 2020 in a total of 100 patients diagnosed with fatty liver disease by ultrasonography. The fasting blood was collected for lipid profile and carried out in the automated analyzer following standard protocol.

Result In 100 cases, the male to female ratio was 1.8:1. Fifty six percent of the total cases presented with alcoholic fatty liver disease (AFLD) while the remaining 44% with non-alcoholic fatty liver disease (NAFLD). The spectrum of lipid abnormality was observed with increased total cholesterol (TC), Low Density Lipoprotein (LDL), increased triglycerides (TG), Very Low Density Lipoprotein (VLDL) in alcoholic fatty liver disease cases as compared to non-alcoholic fatty liver disease cases. However, it has been observed that TG/HDL and Non-HDL/HDL were higher in non-alcoholic fatty liver disease as compared to alcoholic fatty liver disease. Moreover, a statistically significant difference was observed in HDL between AFLG2 and NAFLG2 (p-value: 0.012).

Conclusion Dyslipidemia and decreased HDL have been implicated in fatty liver diseases. USG in conjunction with Non-HDL/HDL, TG/HDL, hemoglobin, and albumin can be useful in early screening and monitoring of dyslipidemia in fatty liver patients.
Supraclavicular Brachial Plexus Block: Comparison of Varying Doses of Dexmedetomidine with Ropivacaine
Authors: Shakya S. , Singh J. , Ghimire A. , Shrestha B.
Published: November 2022

Background Alpha-2 adrenergic receptor agonists have been the focus of interest nowadays as an adjuvant to local anesthesia due to its excellent sedative, analgesic, antihypertensive, anesthetic sparing and hemodynamic stabilizing properties. The ideal dose of dexmedetomidine for brachial plexus block is matter of debate.

 Objective To find the appropriate minimal dose of dexmedetomidine with desired clinical effects and minimal side-effects, we compared different doses (25 mcg, 50 mcg, 75 mcg and 100 mcg) of dexmedetomidine as an adjuvant to ropivacaine.

Method One hundred fifty patients of ASA I and II, aged (18-60) years, weighing (50-60) kilograms undergoing upper limb surgeries under brachial plexus block were enrolled in this prospective, double blind, randomized control study. Patients in all group received 19 ml of 0.5% ropivacaine in common. In addition; group RD25, RD50, RD75 and RD100 received 25 mcg, 50 mcg, 75 mcg and 100 mcg of dexmedetomidine diluted in 1 ml of normal saline (NS) respectively whereas group RD00 received only 1 ml of NS. The duration of analgesia was the primary outcome whereas block characteristics, hemodynamic parameters, oxygen saturation, sedation score and adverse effects were taken as secondary outcome. Statistical analysis was done using ANOVA test, Chi-square test and Scheffe’s multiple comparison tests.

Result The demographic profile and baseline hemodynamic variables were comparable in all five groups. Increasing dose of dexmedetomidine showed significant improvement in block characteristics but associated with increase in sedation and incidence of bradycardia.

Conclusion We conclude that dexmedetomidine 50 mcg would be an appropriate dose as adjuvant to local anesthesia in brachial plexus block.
Effectiveness of Visual Inspection with Acetic Acid and Cervical Cytology in Early Detection of Precursors of Cervical Cancer in Nepal
Authors: Dongol Singh A. , Shakya S. , Mudbari J.
Published: November 2022

Background Cervical cancer ranks as the first, most frequent cancer amongst Nepalese women. This can be prevented through primary prevention and early detection using screening techniques. Though cervical cytology is a standard screening tool in most of the developed countries, it fails to be the screening method of choice in low and middle income countries (LMICs) with limited resources due to financial and technical constraints.

Objective This study aims at early detection of pre-cancerous lesion in cervix with cervical cytology and visual inspection with acetic acid.

Method This is a hospital based, descriptive cross-sectional study. It included 104 women attending Obstetrics and Gynecology out-patient department (OPD) in Dhulikhel Hospital. Visual inspection of cervix with acetic acid (VIA) and liquid based cytology (LBC) was performed followed by cervical biopsy for positive VIA, or having abnormal cytology, or having unhealthy appearance of cervix even after treatment.

Result The incidence of positive VIA and cytology screening was 38.5% and 7.7% respectively. The negative predictive value of VIA and cytology were similar whereas VIA was found to be more sensitive than cytology.

Conclusion Cytology screening is used as an investigation of choice for screening of cervical cancer. In Nepal, VIA can be a good alternative for early detection of cervical cancer as it is found to be more sensitive than cytology.
Vaginal Atresia with Cervical Agenesis, a Rare Congenital Malformation
Authors: Regmi D. R. , Dangal G. , Karki A. , Pradhan H. K. , Shrestha R. , Bhattachan K. , Tiwari K. D. , Bharati S. , Manandhar P. , Maharjan S.
Published: November 2022

Congenital vaginal atresia and cervical agenesis is a rare congenital abnormality of the female genital tract. Here we report a case of 15-year old girl with primary amenorrhea with hematometra, presented with lower abdominal mass. She was symptomatic since 5 months and visited local hospital after 4 months of onset of her symptoms when it became severe, where diagnostic laparotomy was performed for suspected Adnexal mass. Intraoperatively adnexal mass was adhered with and extended up to the uterus with 16 weeks size of uterus. Abdomen was closed without any further intervention and was referred to higher center for needful. When she presented to Kathmandu Model Hospital, she was asymptomatic on her 5th post-operative day of laparotomy. We planned for surgical intervention after examination and investigation. Drainage with vaginoplasty with amnion graft with placement of mould was done.
Juvenile Generalized Myasthenia Gravis: Presented as Unilateral Blepharoptosis and Successfully Managed with Pulse Intravenous Methylprednisolone
Authors: Poudel P. , Anand A. , Ghosh S.
Published: November 2022

Myasthenia Gravis is a rare autoimmune disorder of childhood and this is rarer in South Asia. We present a pre-pubertal 7 year old female child of seropositive Generalized Juvenile Myasthenia Gravis. She presented with unilateral blepharoptosis and later generalized symptoms appeared. Ice-pack test, Neostigmine challenge test and acetylcholine receptor antibody test were positive. Serum muscle specific tyrosine kinase antibody test was normal. She did not have thymic abnormalities. She did not respond to high dose (26 mg/kg/day) of Pyridostigmine and oral Prednisolone (2 mg/kg/day), but was successfully treated with a combination of pulse intravenous Methylprednisolone (30 mg/kg once a month for 6 months) and daily doses of oral Prednisolone (2 mg/kg/day) along with Pyridostigmine without significant side effects. This combination can be considered a potential inexpensive treatment for Juvenile Myasthenia Gravis in a resource limited area where other immunosuppressive treatments such as intravenous immunoglobulin is expensive and unaffordable.
A review of the liberal theory of justice: Women’s invisible contributions to family
Authors: Aránzazu Novales Alquézar María
Published: November 2022

The cunning of separating the public and private spheres, stealing from the latter all the value, tarnishes the origins of some of the most important political theories of nowadays, as is the case with the liberal theory of justice. The consequence is that, in a sibylline manner, there is a systematic appropriation of the emotional and affective force and care capabilities of women, which has many negative consequences for them and for social cohesion. Occidental feminist theory has interrogated and displaced the border between these two worlds, public and private. As some socialist and marxist sectors have shown, the family absorbs, without compensation, the actions of women as identity builders, free wound healers of others and feeders of foreign egos. The broad spectrum of work that must be carried out to guarantee generational change and social functioning, arduous but invisible, is actually and it should be shown in social practice, a collective responsibility.
Love and marriage: Revisiting patriarchy and matriarchy in biblical narrative
Authors: Weiler Joseph H.H.
Published: November 2022

The article deals with various patterns of marriage relationships which were depicted in the Old Testament (Book of Genesis). Three types of marriages are distinguished there based, inter alia, upon the love relationships of the patriarchs: Abraham, Isaac and Jacob. Those patterns are founded upon the realism of the Bible narrative which provides for different, sometimes difficult and “loveless”, relationships among the couples. The article also argues that gender was not always determinative of the functional and even public role of the Patriarchs and Matriarchs where, for example, Rebecca, not Isaac, is in all but name the veritable “Patriarch”.
Getting dressed or why feminists should take this question seriously
Authors: Evans Mary
Published: November 2022

The article deals with demands made upon women about their appearance in the 21st century, comments made by, and about, women and the ways in which they dress. That is the suggestion that there is a greater plurality about dress in the contemporary world than it was in the world of our grandmothers. But in place of the former strictures there are others: demands about youth and youthfulness, of forms of self association either for or against class and racialised others, of representing a human, dressed, version, of the “new”. All represent aspirations for identifying – or not – the self through dress. The question of who do we want to look like is one that is unavoidable.
Evaluation of Continuous Renal Replacement Therapy Results Applied in the Intensive Care Unit
Authors: AKBUDAK İlknur Hatice , ERDOĞAN Çağla , AKBUDAK İsmail Hakkı
Published: November 2022

Purpose: Acute kidney injury diagnosed patients are in need of renal replacement therapy (RRT). Continuous RRT is believed to be safer because the rates of fluid and solute removal are slower than with intermittent hemodialysis. In many centers, CRRT is preferred in special conditions such as increased cranial pressure, sepsis, burns, heart and liver failure. In our study, we present one year data of CRRT usage in our ICU.

Materials and methods: This study included the patients who admitted to the Internal Medicine Intensive Care Unit of our university between January 2019 and June 2020. Among these patients, those over 18 years of age and those who had acute renal failure during their hospitalization and received continuous renal replacement therapy were included in the study.

Results: Mean SOFA scores at admission were 2.7 which is an indication for severe disease. Lengths of ICU stay were long and approximately 77 percent of these patients died in ICU. When the comorbid conditions of the patients were examined, it was seen that oncological diseases were the most common. It was followed by hypertension, diabetes mellitus and heart diseases. Considering the KDIGO scores of the patients diagnosed with AKI, it was seen that 60 percent of them were grade 5. Treatment could be applied for an average of 25 hours.

Conclusion: Indications, timing and benefits of CRRT are the questions that need to be research and yet remained unsolved. With evolving of technology, CRRT will be our most useful helper in ICUs.
The Canadian Travel Film Library: Non-Theatrical Distribution and Tourism Promotion in the Postwar Period
Authors: Brégent-Heald Dominique
Published: November 2022

En 1947, l’Office national du film créait le Canadian Travel Film Library (CTFL), dont l’un des mandats était de louer des courts métrages en 16mm qui faisaient la promotion des attraits touristiques et récréatifs du pays auprès de millions d’emprunteurs aux États-Unis. La publicité touristique par le biais du cinéma faisait partie d’une stratégie plus large afin d’injecter des dollars américains dans l’économie canadienne de l’après-guerre et ainsi remédier au déséquilibre commercial avec les États-Unis. Les représentants du gouvernement estimaient que ces films à petite pellicule constituaient le format idéal pour atteindre un public large à un coût moindre et, ainsi, favoriser son plan de reconstruction. De plus, en soutenant l’industrie du tourisme, l’ONF cherchait à faire taire les critiques selon lesquelles elle constituait une agence de propagande gauchiste disposant d’un budget excessif. En fait, son budget réduit limitait sa capacité à produire ses propres films touristiques. C’est pourquoi l’Office a développé un mécanisme de distribution centralisé qui œuvrait en dehors des salles de cinéma : le CTFL, qui opérait à partir de bureaux à New York et à Chicago et desservait des dizaines de points de distribution régionaux. Travaillant étroitement avec l’Office des voyages du gouvernement canadien, l’ONF a ainsi rationalisé la diffusion aux États-Unis des copies en 16mm par les agences fédérales et provinciales, ainsi que par les intérêts privés.
Mediating role of dyadic satisfaction on social support and health outcomes in a sample of military family care-givers
Authors: Wilcox Sherrie
Published: November 2022

LAY SUMMARY

Military family caregivers (MFCs) can experience many health-related challenges associated with caregiving responsibilities. Perceived support from a spouse or partner can influence dyadic satisfaction and health outcomes among those who care for a spouse or partner. This study examined the relations among social support, dyadic satisfaction, and mental (i.e., depressive and anxiety symptoms) and physical (i.e., somatic symptoms) health outcomes in a sample of MFCs. This sample consisted of 104 MFCs who were the spouse or partner of their care recipient. The findings indicate that more support predicted greater dyadic satisfaction and greater dyadic satisfaction predicted fewer anxiety symptoms. This study highlights the importance of considering relationship-focused contributors to mental health outcomes.
Peningkatan Kemahiran Menulis Arab Melalui Penerapan Pembelajaran Baca Tulis Al-Qur’an
Authors: Zulianah Evi , Muchtar Nicky Estu Putu , Robikhah Aridlah Sendy
Published: November 2022

This article aims to describe the application of Al-Qur'an Reading and Writing Learning for Class X Students of MAN 1 Lamongan. This research uses a qualitative approach and the type of research is a case study. The data needed in this study are primary data that must be carried out through interviews and observations, as well as secondary data such as profile documents, drafts of BTQ learning programs, photos of teaching and learning activities for MAN 1 Lamongan students, and other documentation that can support the validity of research results. this and can be accounted for. The outputs in this study are the Sinta 4 Journal, ISBN Books, and HKI Written Papers. The Arabic writing skills of the tenth graders of MAN 1 Lamongan before using the BTQ book were very low. Meanwhile, Arabic writing skills after applying BTQ therapy books are getting better and better. The supporting factors are the high motivation of students, the habit of listening to murottal, and more abilities for students who graduate from Madrasah Ibtidaidah, Madrasah Tsanawiyah, and Islamic Boarding Schools. The inhibiting factors are: Physical condition that is tired due to the demands of school assignments, Class Conditions, Teacher Conditions, and Student Inactivity. To perfect the solution that has been applied, the teacher should refresh or prepare an interesting method before learning to read and write the Qur'an.
First record of the genus Parascleroderma (Hymenoptera: Bethylidae) from Russia, with the description of two new species
Authors: Fadeev K.I.
Published: November 2022

The genus Parascleroderma Kieffer, 1904 belonging to the subfamily Pristocerinae is recorded from Russia for the first time. Two new species of this genus are described and illustrated from males: P. astrakhanicum sp. nov. from the Astrakhan Province and P. austrouralicum sp. nov. from the Orenburg Province. A key for both Russian species is provided. Morphological differences of the pristocerine genera Parascleroderma and Foenobethylus Kieffer, 1913 are discussed.
Effects of Transfer Energy Capacitive and Resistive On Musculoskeletal Pain: A Systematic Review and Meta-Analysis
Authors: Sadri Soroush , Vahdatpour Babak , Haghighat Shila , Sadri Leyli , Taghian Mehdi
Published: November 2022

The use of transfer energy capacitive and resistive (TECAR) therapy to treat musculoskeletal pain has not been clearly established. Hence, this study was conducted to combine the available results. We searched the main databases, including PubMed (January 1950), Web of Knowledge (January 1945), Scopus (January 1980), and ProQuest (January 1983) until December 2021, to find the related studies. Only those studies were included that assessed the pain in participants who received TECAR therapy and compared it with a control group. Using the random effect model, standardized mean difference (SMD) was calculated at a 95% confidence interval (CI). The differences between patients and control group were -1.04 after four weeks of intervention (95% CI: -1.59 to -0.48, I2=86.9%) and -1.80 after eight weeks (95% CI: -2.15 to -1.46, I2=87%), which was significant (P<0.001). The intra-group pain comparison before and after two, four, and eight weeks of TECAR therapy obtained SMD levels of -3.96 (95% CI: -5.28 to -2.65, I2=96.9%), -4.12 (95% CI: -5.98 to -2.26, I2=97.3), and -5.03 (95% CI: -7.23 to -2.83, I2=92.2%), respectively. Despite some limitations, our findings may assist clinicians in decision-making about TECAR therapy for the approach to musculoskeletal pain based on evidence-based medicine.
UMA PROPOSTA DE LEITURA VOCALIZADA DE “A MÃE DO CATIVO” DE CASTRO ALVES
Authors: De Oliveira Alexandra Almeida , Camargo Goiandira Ortiz de
Published: November 2022

Este trabalho se propõe a apresentar uma leitura vocalizada e comentada do poema “A mãe do cativo”, de Castro Alves, enfeixado na coletânea Os escravos, publicada postumamente em 1883. Para tanto, seguimos algumas diretrizes determinadas por estudiosos da área e do campo da hermenêutica literária em geral, como: Paul Zumthor (2010), Élie Bajard (2005), Jean Cohen (1974), Giorgio Agamben (2002, 2012), Alfredo Bosi (2010), dentre outros. Antes de passarmos à interpretação do poema e a considerações acerca de sua leitura vocalizada, tecemos algumas considerações sobre o percurso empreendido para se efetuar a vocalização.
“Na chuva que cessa”:
Authors: Pereira Patrícia Resende
Published: November 2022

O presente artigo tem o intuito de discutir a maneira como a imagem da chuva se faz presente na obra do escritor português Fernando Pessoa. Para tanto, foi selecionado o fragmentos do Livro do desassossego, escrito por Bernardo Soares, semi-heterônimo de Pessoa, e o poema “Chuva Oblíqua”, do ortónimo Pessoa. Ao se estabelecer uma relação entre os textos, percebe-se que, no primeiro, a chuva aparece relacionada ao estado de espírito do poeta, como uma forma de refletir sobre o sentir, temática já recorrente nos escritos de Soares, enquanto no segundo, a imagem é o ponto de partida para uma viagem entre o exterior e o interior do ambiente, com quase nenhuma discussão sobre sentimentos.
DIÁLOGO INTERMÍDIAS E FORMAÇÃO DE NOVOS LEITORES LITERÁRIOS:POTENCIALIDADES
Authors: Lucena Soares Adriana Spineli , Ferreira Elizete Albina
Published: November 2022

O presente artigo propõe, a partir da leitura da obra Letramento literário: teoria e prática (2014), de Rildo Cosson, demonstrar a importância do diálogo intermídias para a formação de novos leitores de literatura. Entretanto, para reconfigurar o olhar sobre as obras literárias, sua leitura e estudo, é indispensável avaliar o que é significativo para o estudante e se está pertinente as suas práticas sociais. Assim, acredita-se que o professor se sinta responsável em fazer uso de estratégias no sentido de tentar aperfeiçoar esse contato entre texto e leitor, com a finalidade de promover um diálogo intermídias através do olhar literário ambicionado na prática da formação de novos leitores. O estudo evidenciou que o uso das intermídias, aliado à perspectiva da formação de novos leitores literários, tem a capacidade de favorecer a aproximação entre ensino e realidade social, o que configura uma aprendizagem significativa, tendo em vista que os alunos consomem e produzem conteúdos interligados às intermídias e que a escola, portanto, deve aliar-se a essas práticas a fim de favorecer a formação integral de agentes do conhecimento e, ao mesmo tempo, atualizar-se no contexto contemporâneo, atendendo à pressuposição do documento norteador para a educação brasileira, BNCC.
AMPLIAÇÃO DE REPERTÓRIOS NO PROCESSO DE LEITURA CRÍTICA:UM MOVIMENTO DE (DES/RE)TERRITORIALIZAÇÃO NA CONSTRUÇÃO DE SENTIDOS
Authors: Sabota Barbra , Steckelberg Hellen
Published: November 2022

Apesar de ser tomada como tácita, a leitura crítica apresenta desafios para estudantes universitárias/os. Neste artigo revisitamos uma proposta de leitura crítica e registro narrativo reflexivo desenvolvida durante o Programa Institucional de Iniciação à Docência (Pibid) da Universidade Estadual de Goiás (UEG) entre outubro de 2020 e março de 2022. As atividades foram realizadas no subnúcleo Pibid Inglês Anápolis cujo plano de trabalho previa o desenvolvimento de aulas de inglês a partir dos Letramentos Críticos e da estudos da multimodalidade. Compõem o material empírico deste estudo o portfólio mensal e o relato de experiência de uma bolsista do programa bem como as memórias sobre a experiência vivenciada por ela e a coordenadora do programa, que assinam este texto. Trata-se de um estudo autoetnográfico pós-qualitativo cujo material empírico foi rizomatizado em busca das des/reterritorializações provocadas durante a análise. Conclui-se que a leitura crítica pode fazer emergir saberes que extrapolam os campos acadêmicos e contribuem para o autoconhecimento e a formação humana.

Palavras-chave: Leitura crítica. Rizoma. Construção de sentidos.
The mediation effect of destination image on the relationship between local cuisine elements and destination selection: The case of Hatay
Authors: DUMAN Damla , SAÇLI Çağrı
Published: November 2022

This study aims to empirically test a model linking destination image, destination selection, and local cuisine elements. The study also analyzes the mediating effect of destination image on the relationship between local cuisine elements and destination selection. The research data were collected from domestic tourists using a survey from the UNESCO Gastronomy City of Hatay of Türkiye. All four hypotheses suggested within the scope of the study were supported. Local cuisine elements and destination image significantly influence destination selection; herein, local cuisine elements affect destination selection more. Similarly, local cuisine elements significantly influence destination image. This study also reveals that destination image partially mediates the relationship between local cuisine elements and destination selection. The study results are expected to help the researchers and managers understand the roles of local cuisine elements and destination image in destination selection in the tourism industry. The study is the first to explore the mediating relationship in link between local cuisine and destination selection in the tourism industry.
HMGCS2-Induced Autophagic Degradation of Tau Involves Ketone Body and ANKRD24
Authors: Hu Li-Tian , Xie Xiao-Yong , Zhou Gui-Feng , Wen Qi-Xin , Song Li , Luo Biao , Deng Xiao-Juan , Pan Qiu-Ling , Chen Guo-Jun
Published: November 2022

Background: Accumulation of hyperphosphorylated Tau (pTau) contributes to the formation of neurofibrillary tangles in Alzheimer’s disease (AD), and targeting Tau/pTau metabolism has emerged as a therapeutic approach. We have previously reported that mitochondrial 3-hydroxy-3-methylglutaryl-COA synthase 2 (HMGCS2) is involved in AD by promoting autophagic clearance of amyloid-β protein precursor via ketone body-associated mechanism, whether HMGCS2 may also regulate Tau metabolism remains elusive. Objective: The present study was to investigate the role of HMGCS2 in Tau/p degradation. Methods: The protein levels of Tau and pTau including pT217 and pT181, as well as autophagic markers LAMP1 and LC3-II were assessed by western blotting. The differentially regulated genes by HMGCS2 were analyzed by RNA sequencing. Autophagosomes were assessed by transmission electron microscopy. Results: HMGCS2 significantly decreased Tau/pTau levels, which was paralleled by enhanced formation of autophagic vacuoles and prevented by autophagic regulators chloroquine, bafilomycin A1, 3-methyladenine, and rapamycin. Moreover, HMGCS2-induced alterations of LAMP1/LC3-II and Tau/pTau levels were mimicked by ketone body acetoacetate or β-hydroxybutyrate. Further RNA-sequencing identified ankyrin repeat domain 24 (ANKRD24) as a target gene of HMGCS2, and silencing of ANKRD24 reduced LAMP1/LC3-II levels, which was accompanied by the altered formation of autophagic vacuoles, and diminished the effect of HMGCS2 on Tau/pTau. Conclusion: HMGCS2 promoted autophagic clearance of Tau/pTau, in which ketone body and ANKRD24 played an important role.
Investigation of the effect of the career management system and succession plan on employees’ work stress and feelings of entrapment
Authors: Aslan Mustafa , Lee Yu-Feng L. , Yaman Fatih , Aksu Ayhan
Published: November 2022

BACKGROUND: Work stress and feeling of entrapment are harmful physical and emotional results for employees when the workload demands exceed their capacities. OBJECTIVE: This study aims to investigate the effects of the career management system and succession plan on employees’ work stress and feelings of entrapment in hopes of improving employees’ well-being to promote business continuity. METHODS: In this cross-sectional study, the convenient sampling method was adopted. The research was conducted with the participation of call center agents (n = 621) of three call centers in Turkey. The Partial Least Squares Structural Equation Modeling (PLS-SEM) path analysis was performed on the collected data for hypothesis testing. RESULTS: Both career management systems (CMS) and succession plans (SP) reduce employees’ work stress and feelings of entrapment. Work stress was found to mediate the effects of CMS and SP on the Feeling of Entrapment. The CMS reduces the work stress of employees with university degrees than those with a high school diploma. Meanwhile, SP reduces more of the feeling of entrapment for employees newly starting their jobs (with 0–2 years of seniority) than the workers with three or more years of seniority. CONCLUSION: Empirically, the feeling of entrapment seems higher among the employees with three or more years of seniority, suggesting that human resource management should focus on employees’ work stress and feeling of job insecurity issues and offer possible and timely solutions. Furthermore, organizations showing care to newly arriving staff and giving them job assurance is believed crucial to improving employees’ recruitment and retention.
KEBUTUHAN PERAWATAN PERIODONTAL PADA PASIEN RSGM FKG UPDM (B) PADA PERIODE NOVEMBER-DESEMBER 2019: SURVEI CPITN
Authors: Fidyawati Desy , Septnina Veronica
Published: November 2022

Latar belakang: Inflamasi periodontal mengenai jaringan pendukung gigi meliputi ligamen periodontal dan kerusakan tulang alveolar. Tanda klinis yang umumnya dijumpai diantaranya  warna kemerahan pada gingiva, disertai perdarahan, resesi gingiva dan kegoyangan gigi. Evaluasi kondisi jaringan periodontal  untuk mengamati gambaran klinis dan kondisi jaringan periodontal dapat diukur pada individu dan komunitas dengan menggunakan indeks Community Periodontal Index of Treamnet Needs (CPITN) Tujuan: Penelitian ini bertujuan menunjukkan bahwa prevalensi dan keparahan penyakit periodontal dapat dipengaruhi oleh jenis kelamin, gingivitis memiliki prevalensi yang lebih tinggi pada pria dibandingkan wanita, hal ini dapat disebabkan adanya perbedaan kebiasaan yang mempengaruhi terjadinya gingivitis. Metode penelitian: Penelitian ini dilakukan di Rumah Sakit Gigi Mulut Universitas Prof. Dr. Moestopo (Beragama) dengan menggunakan penilaian survei CPITN, untuk menilai kebutuhan perawatan antara laki-laki dan perempuan pada pasien (usia 20-30 tahun) yang berobat di RSGM UPDM (B) pada kurun waktu November-Desember 2019. Hasil penelitian: Berdasarkan penilaian CPITN, score 1 untuk laki-laki 35% (14 subyek), perempuan 25% (10 subyek); score 2, laki-laki 12,5% (5 subyek), perempuan 22,5% (9 subyek); score 3, laki-laki dan perempuan 2,5% (1 subyek). Kesimpulan: Kebutuhan perawatan periodontal terbanyak adalah pada skor 1 untuk laki-laki sebanyak 14 subyek (35%) dan perempuan 10 subyek (25%), yang artinya dibutuhkan peningkatan OH, melalui oral prophylaksis. Untuk Skor 2, jumlah wanita lebih banyak, yang artinya dibutuhkan peningkatan OH dan tindakan pembersihan karang gigi.
PERBANDINGAN AKURASI PENGUKURAN PANJANG KERJA MENGGUNAKAN METODE RADIOGRAFI DAN ELEKTRONIK PADA PERAWATAN ENDODONTIK
Authors: Soerachman Badi , Sidiqa Atia Nurul , Endrowahyudi Hartanto
Published: November 2022

Latar belakang: perawatan saluran akar bertujuan untuk menghasilkan kondisi lingkungan saluran akar yang sehat melalui proses penyembuhan akibat perawatan kontinu jaringan periradikuler yang mengalami infeksi. Salah satu faktor yang mempengaruhi keberhasilan perawatan saluran akar adalah akurasi pengukuran panjang kerja. Metode yang umum digunakan dalam menentukan panjang kerja adalah radiografi dan elektronik. Metode radiografi dipengaruhi kualitas foto radiografi, sedangkan metode elektronik penggunaannya mudah namun tidak dapat memberikan informasi mengenai bentuk akar, jumlah akar, dan arah lengkung akar yang akurat. Tujuan : penelitian ini membandingkan tingkat akurasi pengukuran panjang kerja yang diukur dengan metode radiografi dan elektronik. Metode : sebanyak 30 gigi permanen rahang bawah yang telah diekstraksi dengan saluran akar tunggal, lurus, dan apikal telah tertutup dengan  sempurna dipotong horizontal pada garis servikal (cementoenamel junction) dengan menggunakan carborundum kemudian dipreparasi menggunakan File K #10 dan #15 secara berurutan. Sampel gigi kemudian dilakukan pengukuran panjang saluran akar dengan metode radiografi parallel, electronic apex locator (SybronEndo) dan pengukuran aktual yang kemudian diamati dengan menggunakan kamera lensa makro 100 mm. Data kemudian dilakukan analisis statistik dengan uji t Hasil : hasil penelitian menunjukkan bahwa keakuratan pengukuran panjang kerja dengan metode elektronik terdapat pada sebanyak 17 sampel dari 30 sampel (56.7%) sedangkan pengukuran dengan metode radiografi hanya 1 sampel dari 30 sampel (3.3%). Kesimpulan : pengukuran panjang kerja dengan menggunakan metode radiografi dan elektronik memiliki akurasi yang sama. Kedua metode pengukuran menunjukkan nilai yang lebih mendekati panjang kerja aktual. Penelitian lebih lanjut secara in vivo perlu dilakukan karena hal ini menjadi keterbatasan yang dapat mempengaruhi ketepatan pengukuran dengan alat elektronik.
PENATALAKSANAAN TRAUMA PADA GIGI ANTERIOR DESIDUI (LAPORAN KASUS)
Authors: Sari Nendika Dyah Ayu Murika , Mahendra Putri Kusuma Wardani
Published: November 2022

Latar Belakang : Trauma gigi sering terjadi pada anak - anak, sekitar 30-40% anak-anak setidaknya mengalami satu kali trauma injuri pada gigi desidui. Trauma gigi yang paling banyak dialami pada masa anak-anak adalah intrusi gigi. Perawatan pada gigi desidui yang mengalami traumatic injury harus dilakukan bukan hanya karena alasan estetik atau fungsional, melainkan traumatik injuri gigi desidui dapat berdampak pada perkembangan dari benih gigi permanen. Tujuan dari penulisan ini adalah untuk mengetahui penatalaksaan traumatik injuri gigi anterior desidui dengan intrusi apeks ke arah palatal disertai luksasi. Laporan kasus : seorang anak perempuan berusia 3 tahun datang bersama orang tuanya dengan keluhan anak jatuh tertimpa kursi. Gigi depan goyang dan berdarah.  Hasil pemeriksaan klinis didapatkan intrusi apeks ke arah palatal pada gigi 51 disertai luksasi derajat 2. Penalataksaan pada kasus ini adalah dengan melakukan ekstraksi gigi 51 dengan anestesi infiltrasi. Dua minggu setelah pencabutan, luka sudah menutup tetapi belum sempurna dan tidak ada komplikasi. Kesimpulan : Penalataksanaan kasus trauma gigi desidui harus mempertimbangkan pengaruhnya terhadap kondisi gigi permanen. Pencabutan menjadi pilihan perawatan yang tepat untuk kondisi gigi desidui anterior yang mengalami trauma dengan kondisi intrusi apeks mengarah ke palatal dan disertai dengan luksasi derajat 2, karena dapat membahayakan kondisi gigi permanen.
SUPERBASES IN ORGANIC SYNTHESIS
Authors:   A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences, Trofimov B.A. , Schmidt E.Yu. ,   A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
Published: November 2022

In this concise review, an emphasis is laid on the important role of superbases as catalysts and reagents in organic synthesis that so far remain underestimated. Diverse approaches to understand the superbasicity phenomenon are considered and the definition of superbase is given. Typical compositions of most widespread superbase systems are systematized and tabulated. The representative classic organic reactions assisted by superbases are surveyed.
СУЧАСНІ ВИКЛИКИ МЕНЕДЖМЕНТУ ЛЮДСЬКОГО КАПІТАЛУ
Authors: Вараксіна Олена , Карлінська Олена , Петренко Вадим
Published: November 2022

Стаття присвячена актуальним проблемам людського капіталу, зокрема розглянуто погляди українських дослідників щодо сутнісної характеристики поняття «людський капітал». Актуальність дослідження зумовлена необхідністю оптимізації наявних механізмів управління людським капіталом та систем показників його оцінки, адже сучасні виклики, які стоять не тільки перед нашою державою, а в цілому перед усім світом вимагають негайного реагування та адаптації у відповідності до факторів впливу. Визначено, що розвідка людського капіталу здійснюється, в основному, на мега-, мезо- та мікрорівні, запропоновано вивчення даної проблематики проводити також на рівні колективу, сімейному та індивідуальному рівнях, оскільки особисті якості, цінності, компетентності тощо неможливо відділити від людини. Зазначено, що головним призначенням людського капіталу є створення й поширення інновацій, використання яких надає компанії справжні конкурентні переваги.
ТРАЄКТОРІЇ РОЗВИТКУ ОСНОВНИХ ВИДІВ ЕКОНОМІЧНОЇ ДІЯЛЬНОСТІ УКРАЇНИ У ПОВОЄННИЙ ПЕРІОД
Authors: Кузнєцова Лідія
Published: November 2022

Стаття присвячена результатам дослідження наслідків повномасштабного вторгнення рф для економіки України та визначенню головних завдань по її відновленню, головним з яких є вибір між тим, чи буде наша країна відновлювати свою економіку сировинно-аграрного типу або ж почне будувати економіку, що базуватиметься на новому технологічному укладі, економіку знань та технологій. Від того, який шлях вибере Україна у значному ступені залежатимуть підходи до вирішення конкретних завдань по відновленню зруйнованого війною. В статті визначені основні чинники скорочення виробництва по основних видах економічної діяльності, окреслено головні завдання по відновленню економіки у повоєнний період з урахуванням тих мегатрендів розвитку світової економіки, які сформувались зокрема як відповідь пост-пандемічного простору, а також представлено сценарне оцінювання траєкторій розвитку основних видів економічної діяльності у повоєнний період.
ДЕРЖАВНЕ РЕГУЛЮВАННЯ РОЗВИТКУ МАЛОГО БІЗНЕСУ
Authors: Трегубов Олександр , Клочковська Вікторія , Клочковський Олександр
Published: November 2022

Розглянуто теоретичні підходи до сутності державного регулювання малого бізнесу. Досліджено особливості цих процесів в Україні, акцентовано увагу на нормативно-правовому базисі. Визначено основні результати, які отримано в рамках реалізації стратегічних документів. За даними Індексу легкості ведення бізнесу (Doing Business), проаналізовано основні умови, які створено в країні для розвитку малого підприємництва та динаміку таких процесів. Визначено комплекс проблем макроекономічного та макроекономічного характеру, з якими стикаються суб’єкти малого бізнесу. Сформовано пріоритетні напрями державної регуляторної політики, спрямованої на розвиток малого бізнесу, які дозволять активізувати його діяльність, забезпечити зайнятість населення та пом’якшать негативний вплив сучасних викликів на економіку України.
АДМІНІСТРУВАННЯ АКЦИЗНОГО ПОДАТКУ У КОНТЕКСТІ ЙОГО ФІСКАЛЬНОЇ ЕФЕКТИВНОСТІ
Authors: Тучак Тетяна , Шейко Наталя
Published: November 2022

Стаття присвячена актуальній проблематиці адміністрування акцизного податку через призму фіскальної ефективності. Розкрито поняття «адміністрування», розглянуто його трактування, як з позиції держави так і відповідно до думок вітчизняних науковців і дослідників. Визначено позитивні та негативні чинники і фактори, які вагомо впливають на функціонування системи адміністрування акцизного податку. Проведено аналіз і відображено динаміку надходжень та частку акцизного податку в податкових надходженнях та доходах державного бюджету України упродовж 2016–2021 років. За допомогою представленої динаміки можна прослідкувати періоди, в яких акцизний податок краще проявляв свою фіскальну ефективність. Представлено структуру надходжень акцизного податку за групами підакцизних товарів (продукції) упродовж 2016–2021 років у відсотках. Згідно до якої визначено, яка категорія продукції (товарів) більше приносить податкових надходжень у бюджет країни, а яка є менш прибутковою. Спираючись на показники дохідності, зроблено висновки щодо чинників, які на них прямо чи опосередковано впливають. Розраховано динаміку виконання плану за податковими надходженнями акцизного податку упродовж 2016–2021 років. Відповідно до актуальної ситуації в країні зроблено припущення щодо того, що підняття ставок на акцизну продукцію (товари) негативно вплине на дохідну частину бюджету держави. Рекомендовано дотримування не тільки фіскальних інтересів держави у процесі адміністрування акцизного податку, а й врахування інтересів суб’єктів бізнесу, що набуває особливої актуальності в умовах стимулювання післявоєнного розвитку економіки. Таким чином система адміністрування акцизного податку стане більш гнучкою і ефективною.
ШЛЯХИ СТИМУЛЮВАННЯ ЛІДЕРСТВА ТА ІННОВАЦІЙ У ВОЄННИЙ ТА ПОВОЄННИЙ ЧАС
Authors: Яценко Ганна
Published: November 2022

Зважаючи на вагому роль лідерів-управлінців у відновленні економічного зростання країни (як завдяки умінню генерувати та втілювати в життя інноваційні ідеї, так і здатності, навіть, в кризових умовах успішно адаптувати підлеглих до швидко змінюваних ситуацій), у статті розглядаються шляхи стимулювання лідерства, а відповідно і активізації інноваційного розвитку в Україні у воєнний та повоєнний час. Серед запропонованого: по-перше, підтримка і подальший розвиток існуючого в країні бізнесу (в т.ч. через розширення доступу українських МСП до капіталу та до програм навчальної та консультаційної підтримки); по-друге, розбудова потенціалу місцевого бізнесу через формування та реалізацію підприємницького потенціалу молоді, яка генеруватиме інноваційні ідеї в найближчому майбутньому. Встановлено, що вагоме значення у реалізації останнього відіграватиме підвищення якості та практичної спрямованості української освіти.
ЕКОНОМІЧНА БЕЗПЕКА УКРАЇНИ: СОЦІАЛЬНИЙ АСПЕКТ
Authors: Гриник Олена , Сисоєва Інна
Published: November 2022

У статті проведено комплексне дослідження соціальних аспектів економічної безпеки України в контексті соціальної безпеки на основі досліджень наукової економічної літератури та нормативно-правової поведінки. У дослідженні аналізується та визначається перелік заходів, необхідних для досягнення базового балансу між соціальними факторами та економічною безпекою. У процесі дослідження використовуються загальнонауковий метод і спеціально-науковий метод наукового пізнання. Зокрема, використовуються наукові методи дослідження: діалектика, абстрактна логіка, аналіз і синтез структури системи. Означена тема також стосується подальшого розвитку економічної безпеки, спрямованого на вирішення окремих проблем соціальних аспектів економічної безпеки України в умовах військової агресії. Рекомендовано сформулювати стратегію соціальної стабільності суспільства, під якою необхідно розуміти загальні динамічні елементи економічної безпеки, що ведуть до якісної зміни механізму її забезпечення, та вдосконалити її основний зміст у контексті реалій сьогодення з урахуванням особистості, суспільства та інтересів країни, на основі гарантування належного рівня життя громадян, відповідно до їх матеріальних і духовних потреб, з урахуванням необхідності формування людського капіталу, як найцінніший ресурс для економічного розвитку країни.
ДОМІНАНТНІ ОЗНАКИ, ВИДИ ТА ДРАЙВЕРИ РЕЗИЛЕНТНОСТІ ЕКОНОМІЧНОЇ СИСТЕМИ В УМОВАХ ГЛОБАЛЬНОЇ НЕСТАБІЛЬНОСТІ
Authors: Іванюк Уляна
Published: November 2022

Стаття присвячена актуальним питанням дослідження резилентності соціально-економічної системи до глобальних шоків на основі ідентифікації основних параметрів резилентності. Обґрунтовано, важливість та необхідність якісного організаційно-управлінського забезпечення формування резилентної економічної системи. Проаналізовано та систематизовано види резилентності соціально-економічної системи. Окреслено «вроджені» та «набуті» драйвери та ознаки резилентності соціально-економічної системи, яка має здатність до поглинання чи пом’якшення втрат в умовах шоку, а також до реструктуризації і швидкого оновлення в постшоковий період. Зазначено, що важливу роль відіграє «потужність» шоку – чим інтенсивнішим та тривалішим є вплив шоку на соціально-економічну систему, тим довшим є період її реструктуризації та оновлення.