bluuebunny/crossref_metadata_2025 huggingface dataset:
Lipidomics Analysis Explores the Mechanism of Renal Injury in Rat Induced by 3-MCPD
Authors: Wei Tao , Cao Na , Han Tiantian , Chen Yi , Zhou Xingtao , Niu Liyang , Liu Wenting , Li Chang
Published: May 2023

3-monochloropropane-1,2-diol (3-MCPD) is a food-process toxic substance, and its main target organ is the kidney. The present study examined and characterized the nephrotoxicity and the lipidomic mechanisms in a model of kidney injury in Sprague Dawley (SD) rats treated with high (45 mg/kg) and low (30 mg/kg) doses of 3-MCPD. The results showed that the ingestion of 3-MCPD led to a dose-dependent increase in serum creatinine and urea nitrogen levels and histological renal impairment. The oxidative stress indicators (MDA, GSH, T-AOC) in the rat kidney altered in a dose-dependent manner in 3-MCPD groups. The lipidomics analysis revealed that 3-MCPD caused kidney injury by interfering with glycerophospholipid metabolism and sphingolipid metabolism. In addition, 38 lipids were screened as potential biomarkers. This study not only revealed the mechanism of 3-MCPD renal toxicity from the perspective of lipidomics but also provided a new approach to the study of 3-MCPD nephrotoxicity.
Yedoma Permafrost Releases Organic Matter with Lesser Affinity for Cu2+ and Ni2+ as Compared to Peat from the Non-Permafrost Area: Risk of Rising Toxicity of Potentially Toxic Elements in the Arctic Ocean
Authors: Sobolev Nikita A. , Larionov Konstantin S. , Mryasova Darya S. , Khreptugova Anna N. , Volikov Alexander B. , Konstantinov Andrey I. , Volkov Dmitry S. , Perminova Irina V.
Published: May 2023

Pollution of the Arctic Ocean by potentially toxic elements (PTEs) is a current environmental problem. Humic acids (HAs) play an important role in the regulation of PTE mobility in soil and water. The permafrost thaw releases ancient organic matter (OM) with a specific molecular composition into the Arctic watersheds. This could affect the mobility of PTEs in the region. In our study, we isolated HAs from two types of permafrost deposits: the Yedoma ice complex, which contains pristine buried OM, and the alas formed in the course of multiple thaw–refreezing cycles with the most altered OM. We also used peat from the non-permafrost region as the recent environmental endmember for the evolution of Arctic OM. The HAs were characterized using 13C NMR and elemental analysis. Adsorption experiments were conducted to assess the affinity of HAs for binding Cu2+ and Ni2+. It was found that Yedoma HAs were enriched with aliphatic and N-containing structures as compared to the much more aromatic and oxidized alas and peat HAs. The adsorption experiments have revealed that the peat and alas HAs have a higher affinity for binding both ions as compared to the Yedoma HAs. The obtained data suggest that a substantial release of the OM from the Yedoma deposits due to a rapid thaw of the permafrost might increase the mobility of PTEs and their toxicity in the Arctic Ocean because of much lesser “neutralization potential”.
Equatorward Moving Auroral Arcs Associated with Impulse-Excited Field Line Resonance
Authors: Zhao Huayu , Liu Ying , Yang Huigen , Zong Qiugang , Hu Zejun , Zhou Xuzhi , Wang Yongfu , Sun Jicheng , Li Bin
Published: May 2023

The theory of equatorward moving east-west elongated auroral arcs associated with field line resonance (FLR) has been proposed for decades. However, confirming this theory requires in-situ observations of FLR within the magnetosphere and simultaneous all-sky imager observations of equatorward moving auroral arcs near satellite footpoints. In this study, we present the first observations of multiple equatorward moving auroral arcs related to impulse-excited FLR, using datasets from the WIND, Geotail satellites, and an all-sky imager at China’s Zhongshan Station (ZHS) in Antarctica. In the presented event, the ultra-low-frequency waves associated with solar wind dynamic pressure pulse was mainly toroidal mode, which is consistent with the theory that the toroidal mode waves usually related with external source. The all-sky imager located in Zhongshan station recorded several equatorward moving auroral arcs, followed by reverse propagating ones. The latitudinal width of the equatorward moving auroral arcs was on the order of 25 km and had an average equatorward propagation of ~0.37 km/s, which is very similar to the value from previous work. To better illustrate the observed evolution of auroral arcs related with the FLRs we proposed a simple model to evaluate the FACs induced by the FLRs in different latitudes. The latitudinal distribution evolution of FACs agrees well with the ground-based optical observations.
Oort Constants and Local Stellar Kinematics from GCNS
Authors: Guo Sufen , Qi Zhaoxiang
Published: May 2023

Oort constants and local kinematics are vital parameters with which to study the structure and dynamics of the Milky Way. When GCNS was published, it provided a clean sample of stars in the solar vicinity, which gives us an ideal tool with which to determine these parameters. Our aim was to calculate the reliable Oort constants with GCNS. We determined the Oort constants using the GCNS from Gaia EDR3 with d<100pc. The proper motions and radial velocities were fitted with a maximum likelihood model. The uncertainties were obtained with an MCMC method. The sample was carefully selected to obtain a reliable result. The result yields the Oort constants A=15.6±1.6kms−1kpc−1, B=−15.8±1.7kms−1kpc−1, C=−3.5±1.6kms−1kpc−1, and K=2.7±1.5kms−1kpc−1. The non-zero C and K imply that the local disc is in a non-asymmetric potential. With the Oort constants, we derived the local angular velocity Ω0≈A−B=31.4±2.3kms−1kpc−1. The solar motion (U⊙, V⊙, W⊙) was calculated as (10.1±0.1, 22.8±0.1, 7.8±0.1) kms−1.
The Autonomous Parvovirus Minute Virus of Mice Localizes to Cellular Sites of DNA Damage Using ATR Signaling
Authors: Larsen Clairine I. S. , Majumder Kinjal
Published: May 2023

Minute Virus of Mice (MVM) is an autonomous parvovirus of the Parvoviridae family that replicates in mouse cells and transformed human cells. MVM genomes localize to cellular sites of DNA damage with the help of their essential non-structural phosphoprotein NS1 to establish viral replication centers. MVM replication induces a cellular DNA damage response that is mediated by signaling through the ATM kinase pathway, while inhibiting induction of the ATR kinase signaling pathway. However, the cellular signals regulating virus localization to cellular DNA damage response sites has remained unknown. Using chemical inhibitors to DNA damage response proteins, we have discovered that NS1 localization to cellular DDR sites is independent of ATM or DNA-PK signaling but is dependent on ATR signaling. Pulsing cells with an ATR inhibitor after S-phase entry leads to attenuated MVM replication. These observations suggest that the initial localization of MVM to cellular DDR sites depends on ATR signaling before it is inactivated by vigorous virus replication.
Epidemiology and SARS-CoV-2 Infection Patterns among Youth Followed at a Large Los Angeles Health Network during 2020–2022: Clinical Presentation, Prevalent Strains, and Correlates of Disease Severity
Authors: Saleh Tawny , Fuller Trevon , Cambou Mary C. , Segura Eddy R. , Kamau Edwin , Yang Shangxin , Garner Omai B. , Nielsen-Saines Karin
Published: May 2023

Background: Outcomes of SARS CoV-2 infection in infants, children and young adults are reported less frequently than in older populations. The evolution of SARS-CoV-2 cases in LA County youths followed at a large health network in southern California over two years was evaluated. Methods: A prospective cohort study of patients aged 0–24 years diagnosed with COVID-19 was conducted. Demographics, age distribution, disease severity, circulating variants of concern (VOCs), and immunization rates were compared between first and second pandemic years. Logistic regression estimated odds ratios (OR) and 95% confidence intervals (CI) of factors associated with severe/critical COVID-19. Results: In total, 61,208 patients 0–24 years of age were tested for SARS-CoV-2 by polymerase chain reaction (PCR); 5263 positive patients (8.6%) with available data were identified between March 2020 and March 2022. In Year 1, 5.8% (1622/28,088) of youths tested positive, compared to 11% (3641/33,120) in Year 2 (p < 0.001). Most youths had mild/asymptomatic illness over two years. SARS-CoV-2 positivity was >12% across all age groups in the second half of Year 2, when Omicron prevailed. Pulmonary disease was associated with higher risk of severe COVID-19 in both years (OR: 2.4, 95% CI: 1.4–4.3, p = 0.002, Year 1; OR: 11.3, 95% CI: 4.3–29.6, Year 2, p < 0.001). Receipt of at least one COVID-19 vaccine dose was protective against severe COVID-19 (OR: 0.3, 95% CI: 0.11–0.80, p < 0.05). Conclusions: Despite different VOCs and higher rates of test positivity in Year 2 compared to Year 1, most youths with COVID-19 had asymptomatic/mild disease. Underlying pulmonary conditions increased the risk of severe COVID-19, while vaccination was highly protective against severe disease in youths.
Mafosfamide Boosts GMI-HBVac against HBV via Treg Depletion in HBV-Infected Mice
Authors: Lin Qin , Zhong Yiwei , Wang Bin
Published: May 2023

Chronic hepatitis B infection remains a significant worldwide health burden, placing persons at risk for hepatocellular cancer and hepatic fibrosis. Chronic hepatitis B virus (CHB) infection is characterized by elevated levels of immunosuppressive regulatory T cells (Tregs), which can inhibit the function of effector T cells and lead to an insufficient immune clearance response against HBV. Theoretically, suppression of Treg cell functionality and percentage could increase anti-HBV reactivity in CHB-infected patients, although this has not yet been explored. We attempted to enhance our previously established anti-CHB protocol utilizing the GM-CSF+IFN-α+rHBVvac regimen (GMI-HBVac) by incorporating mafosfamide (MAF), which has been utilized in anticancer therapy in the past. Intravenous administration of MAF to rAAV8-1.3HBV-infected mice resulted in a dose-dependent reduction of Tregs in the blood, rebounding to pretreatment levels 10 days later. To assess the potential benefit of adding MAF to the anti-CHB protocol, 2 μg/mL MAF was combined with the GMI-HBVac as an anti-Treg treatment in an HBV-infected animal model. When rAAV8-1.3HBV-infected mice were immunized with MAF+GMI-HBVac, peripheral blood Tregs decreased significantly, leading to dendritic cell activation, HBV-specific T cell proliferation, and the upregulation of IFN-gamma-producing CD8+T cells. In addition, MAF+GMI-HBVac vaccination stimulated T cell infiltration in HBV-infected livers. These effects may contribute to an enhanced immune response and the clearance of HBV-associated antigens, including serum HBsAg, serum HBcAg, and HBcAg+ hepatocytes. Overall, this is the first indication that MAF can act as an adjuvant with GMI-HBVac to deplete Tregs in mice with an established CHB infection. This unique therapeutic vaccine regimen produced a functional cure, as revealed by the remarkable clearance of HBsAg.
Flow Cytometric Features of B- and T-Lmphocytes in Reactive Lymph Nodes Compared to Their Neoplastic Counterparts in Dogs
Authors: Riondato Fulvio , Poggi Alessia , Miniscalco Barbara , Sini Federica , Marconato Laura , Martini Valeria
Published: May 2023

An in-depth knowledge of non-neoplastic patterns is fundamental to diagnose neoplasia. In the present study, we described the flow cytometric (FC) cell size (FSC) and fluorescence intensity (MFI) of B- and T-lymphocytes in 42 canine reactive lymph nodes and 36 lymphomas. Proliferative activity (Ki67%) in reactive lymph nodes was also reported. Reactive lymph nodes were composed of a mixed population of small and large T (CD5+) and B (CD21+) cells. Small T-cells were larger in size than small B-cells, and large T-cells were larger than large B-cells. Small T-cells were composed of CD5+CD21− and CD5+CD21+dim subpopulations. Large B-cells were <20% in reactive lymph nodes and >20% in lymphomas and showed a higher FSC in lymphomas than in reactive lymph nodes. Large T-cells were <4% in reactive lymph nodes and >4% in lymphomas and showed a higher CD5 MFI in lymphomas (if expressed) compared to reactive lymph nodes. A subset of CD5+CD21+dim lymphocytes was recognized in addition to CD5+CD21- and CD5−CD21+ cells. In T-zone lymphomas, neoplastic cells had higher FSC and CD21 MFI values than small CD5+CD21+dim cells in reactive lymph nodes. Ki67% values were higher than those reported in normal lymph nodes, and largely overlapped with those reported in low-grade lymphomas and partially in high-grade lymphomas. Our results may contribute to making a less operator-dependent FC differential between lymphoma and reactive lymph nodes.
COURSE SOFTWARE «PEDAGOGY OF PHYSICAL AND SPORTS ACTIVITIES»
Authors: MOMOT O. , NOVIK S.
Published: May 2023

The article reveals the content and structure of the program of the educational discipline «Pedagogy of physical culture and sports activities», in accordance with the educational and professional training program for applicants of the second (master's) level of higher education in the specialty 014 Secondary education (Physical culture), which was introduced into the educational process of the Faculty of Physical Education of the Poltava Korolenko V.G. National Pedagogical University, the purpose of which is to form in students a system of knowledge and professional and pedagogical skills necessary for organizational, methodical and educational work on issues of physical and sports education.The expected results of training in the discipline are: to name the theoretical foundations of the process of physical and sports education of children of different ages and sexes; theoretical and methodological foundations of physical education in educational institutions of various types; patterns of physical development of children of different ages and sexes; creatively apply the acquired knowledge from the theory of physical and sports education when solving pedagogical, educational, scientific and methodological tasks, taking into account the age and individual differences of children; evaluate and analyze the level of physical development and physical readiness of children of different ages for a certain type of sport; to plan, organize and carry out work on physical and sports education of children of different ages and genders; to form in children a system of knowledge, skills and a conscious need for systematic physical education and sports and a healthy way of life.Scientific studies devoted to the problem of professional and pedagogical training of a physical education teacher have been analyzed.
DIDACTIC POTENTIAL OF SPORTS EDUCATIONAL ROBOTICS
Authors: MATVIIENKO Yu.
Published: May 2023

The article examines the didactic potential and features of the impact on the formation of the student's personality by means of sports and educational robotics. It has been found that in the modern conditions of reforming the educational sector in the direction of introducing STEAM technologies, educational robotics is the tool that facilitates and makes more effective the process of forming 21st century competencies in students of domestic general secondary education institutions.The article provides a brief analysis of the domestic and foreign experience of introducing educational robotics into the educational process and the extent of its influence on the formation of students' personalities and their readiness for further mastery of STEM professions. It was found that there is a lack of scientific and pedagogical research in Ukraine that would describe the didactic potential of introducing educational robotics into the educational process of general secondary education institutions.
K.D. USHYNSKYI’S IDEAS ON THE ROLE OF FAMILY EDUCATION IN DEVELOPING A PERSONALITY
Authors: KRAVCHENKO I. , ZVIAHINTSEVA O.
Published: May 2023

The article describes K. D. Ushynskyi’s pedagogical ideas on the role and importance of family upbringing and its influence on personality development. Family upbringing and personality development play an important role in modern society. The main task of the family education is to prepare children to live in the modern world, and to develop true citizens of a society. The article also analyses K.D. Ushynskyi’s key pedagogical works on family education. It is important to lay the foundation for development and learning in early childhood, and happy childhood definitely has a positive effect on a person's future life. K.D. Ushynskyi considered family education to be the civic duty of every member of society. He claimed that the concept of an educated person consisted of several interacted components, namely: national education, mental education, as well as aesthetic, moral, labor, physical education. The education has to be seen as a single inseparable integrity, in the harmonious interrelation between family and school and their influence on a child.
Border function and tourism relations in the divided cities on the Polish-German border.
Authors: Leśniak-Johann Małgorzata
Published: May 2023

The paper concerns the issue of impact the state border function on cross-border tourist relations in the divided cities on the Polish-German border (i.e. Zgorzelec (Pl)-Goerlitz (G), Gubin (Pl)-Guben (G); Słubice (Pl)-Frankfurt (Oder)(G)). Divided cities have always been a kind of laboratory of cross-border relations, due to their history and functional proximity. The main purpose of the study is to identify stages in the cross-border tourism relation process, taking exogenus (political factors) and endogenous (cross-border cooperation) factors into account and investigate whether these stages refer to theoretical concepts applied in the study (Martinez (1994) and the concept of the bordering- debordering- rebordering process). The analysis concerns the period 1945-2021. The research methods used in the study are analysis of the literature on the subject and direct observations carried out at border crossings in the divided cities during the period 1-4 June 2021. Conclusions: The most important external factor shaping cross-border tourist relations is the political factor and the permeability of the border as its consequence. On this basis, it is possible to distinguish periods for the formation of cross-border tourist relations that relate to Martinez's (1994) types of borderland interaction. However, the conditions for intensification of tourism relations between the parties emerge in the intedependent borderlands and integrated borderlands types of regions, when there is an opportunity to create cross-border tourism relations and cross-border tourism destinations. In the process-oriented terms, all elements of the bordering- debordering- rebordering concept and their reference and consequences to cross-border tourism relations can be described. Using the example of divided cities, it is shown that this is a continuous process, variable over time and highly sensitive to the political factor. Practical implications for local and regional authorities and DMO (Destination Management Organisations) have been formulated regarding the creation of cross-border tourist attractions using the state border as a distinguishing element (e.g. the rich and sometimes difficult German-Polish history, the culture of a Lusatian minority, border smuggling phenomena). The research conducted is regarded as a preliminary stage for further in-depth quantitative research, operationalisation of the model and its empirical confirmation.
Visitors' Satisfaction in Natural Areas: The Case of Vinhais Biological Park
Authors: Alves Diana , Scalabrini Elaine , Vaz Márcia , Teixeira João Paulo , Rivas Rojo Carlos Jesus , Alonso David Muriel , Mestre Lúcia Garrote , Fernandes Paula Odete
Published: May 2023

Satisfaction is a widely studied issue in tourism as it provides an understanding of the performance of a tourism destination's offer, highlighting the most important features considered by tourists. The growth in tourism demand in natural areas also makes it an important factor in identifying visitor satisfaction, as sustainable planning of these areas may also rely on knowing the opinion of their visitors. In this context, this study aimed to determine the visitors´ satisfaction with Vinhais Biological Park, located in the northeast of Portugal, during the summer of 2022. A questionnaire consisting of 8 closed-ended questions to identify the socio-demographic profile and overall satisfaction was applied during July and August 2022. Therefore, 251 valid questionnaires were considered for the quantitative data analysis and a final sampling error of 6.13% was assumed. A descriptive statistical analysis was performed to identify the socio-demographic profile and the satisfaction with the resources offered. Four hypotheses were formulated to test the association between socio-demographic profile (age group, gender, nationality, and education level) and overall satisfaction. The c2 test was used to test the hypotheses assuming a 5% significance level. The main findings showed that the socio-demographic profile of the sample is predominantly male (54.6%), aged between 11 and 40 years (77.6%), of Portuguese nationality (71.3%) and with higher education level (48.6%). Concerning the visit motivation, 61.4% went to the park after visiting the city of Vinhais or the region and nearly half (47%) of the respondents were satisfied. The results of c2 test revealed no significant association between the socio-demographic profile and overall satisfaction,  meaning that none of the hypotheses was supported. Considering the number of visitors received in the park annually, this study's sample can be regarded as a limitation, making the understanding of satisfaction limited to the period of analysis and at a period when the impact of COVID-19 is noticeable. Finally, for future studies, a comparative analysis with other natural parks, both Portuguese and Spanish, is suggested for better monitoring of visitor satisfaction.
Development of Greece as a Sustainable Destination: The Case of Mykonos Island
Authors: Belias Dimitrios , Konstantinos Skagias  , Ioannis Rossidis  , Angelos Ntalakos  , Nikolaos Trihas
Published: May 2023

Mykonos Island is one of the most well-known tourist summer destinations. Every year, especially during the summer period, Mykonos hosts a plethora of tourists that arrive from different countries, such as Italy, France, the United Kingdom, Germany, Spain, and the United Arab Emirates. More specifically, according to Fraport Greece Traffic Data Management, in 2022, there have been 1,668,538 domestic and international arrivals at Mykonos Airport. Mykonos attracts, every year, several types of tourists due to the provided facilities, such as Greek traditional restaurants as well as fancy restaurants with international gastronomy, bars-cafeterias and glamorous clubs and beach clubs, 4 and 5 star hotels, beautiful beaches and beach bars and last but not least a wonderful climate and magnificent scenery. The aim of this paper is to examine the touristic profile of Mykonos Island over the past decade. The tourism industry has been seriously “injured” over the past years (financial crisis, Covid-19 pandemic). This paper will investigate the development of Mykonos Island over the past decade, through data which will be collected by statistical institutes (for instance SETE Institute) and Greek-authorized organizations (such as the Greek Ministry of Tourism). Also, the purpose of the current paper is to examine the case of Mykonos Island as a sustainable destination. Apart from the fact that Mykonos is globally famous for its luxurious image for summer vacations, the island of Mykonos has amazing geographical treasures and a unique environment. Thus, sustainable development needs to be implemented for Mykonos Island, in order to protect the unique environment, improve the existing infrastructure and create a better quality of life for residents and visitors. Hence, this study will focus on the opportunities and the obstacles which could arise from the development of Mykonos as a sustainable destination.
Diagnostic Value of Oximetry for Suspected Necrotizing Enterocolitis in Preterm Infants with Perinatal Encephalopathy
Authors: Гусейнова И.И.
Published: May 2023

Цель исследования. Изучить показатели церебральной и спланхнической оксигенации при подозрении на некротический энтероколит (НЭК) у недоношенных детей с перинатальной энцефалопатией. Материалы и методы. В исследование было включено 32 недоношенных ребенка с перинатальной энцефалопатией с подозрением на НЭК, поступивших в отделение реанимации и интенсивной терапии новорожденных НИИ педиатрии им. К. Фараджевой в период 2019–2021 гг. Результаты. Как показали наши исследования, снижение показателя SCOR при подозрении на НЭК у недоношенных может послужить ценным диагностическим маркером ишемии стенки и использоваться в ранней диагностике НЭК. Заключение. Изучение корреляционных связей между показателями оксиметрии при НЭК у недоношенных детей позволяет прогнозировать течение заболевания и определять лечебную тактику.

Purpose. To study the indicators of cerebral and splanchnic oxygenation in case of suspected necrotizing enterocolitis (NEC) in preterm infants with perinatal encephalopathy. Materials and methods. The study included 32 premature infants with perinatal encephalopathy with suspected NEC admitted to the intensive care unit of the Research Institute of Pediatrics named after K. Faradzheva in the period 2019–2021. Results. As our studies have shown, a decrease in SCOR in case of suspected NEC in preterm infants can serve as a valuable diagnostic marker of wall ischemia and be used in the early diagnosis of NEC. Conclusion. The study of correlations between oximetry parameters in NEC in premature infants makes it possible to predict the course of the disease and determine treatment tactics.
Peculiarities of Hemodynamic Status Assessment in Premature Infants
Authors: Белкин А.М. , Устинович Ю.А. , Бойдак М.П. , Наумов В.В. , Рудкова Н.В.
Published: May 2023

В данном обзоре описаны инструменты, позволяющие оценить гемодинамический статус у недоношенных новорожденных, когда клиницистам часто требуется несколько инструментов для правильной оценки сложного переходного гемодинамического статуса. Он сфокусирован на возможностях и ограничениях каждого метода, подчеркивается взаимодополняемость между непрерывным мониторингом определенных параметров (артериальное давление, оксигенация тканей, измеренная с помощью спектроскопии в ближней инфракрасной области или NIRS), клинической оценкой (темп диуреза, время наполнения капилляров (симптом бледного пятна)), биологическим анализом (концентрация лактата в сыворотке крови) и специфическими исследованиями, такими как эхокардиография, проводимыми периодически. Артериальное давление, измеренное с помощью осциллометрического монитора, должно анализироваться с учетом других клинических данных, в частности симптома бледного пятна, темпа диуреза, измерения уровня лактата в крови. Эхокардиография сердца улучшает неинвазивное управление гемодинамикой у новорожденных, но требует специальной подготовки. NIRS может быть полезен для мониторинга клинического статуса у новорожденных с риском гипотонии или с ее проявлениями. Показано, что не существует предпочтительного метода мониторинга гемодинамики, поскольку каждый инструмент будет предоставлять свою специфическую информацию о ней при определенном патогенезе гемодинамических нарушений в каждом конкретном случае и требует более глубокого изучения данного вопроса у недоношенных новорожденных.

This review describes tools to assess hemodynamic status in preterm infants, where clinicians often require several tools to properly assess complex transient hemodynamic status. It focuses on the capabilities and limitations of each method, emphasizing the complementarity between continuous monitoring of certain parameters (blood pressure, tissue oxygenation measured by near-infrared spectroscopy or NIRS), clinical assessment (diuresis rate, capillary filling time (pale spot symptom), biological analysis (serum lactate concentration) and specific studies such as echocardiography performed periodically. Blood pressure measured with an oscillometric monitor should be analyzed in conjunction with other clinical data, particularly the pale spot symptom, diuresis rate, and blood lactate level measurements. Cardiac echocardiography improves noninvasive hemodynamic management in newborns, but requires special training. NIRS may be useful for monitoring clinical status in newborns at risk for or with signs of hypotension. It has been shown that there is no preferred method of hemodynamic monitoring, as each instrument will provide its own specific information about it in a particular pathogenesis of hemodynamic disturbances in each case and requires a deeper study of this issue in premature newborns.
Pengembangan Alat Ukur Regulasi Emosi Pengasuhan Anak Usia Dini Berdasarkan Strategi Regulasi Emosi J. Gross
Authors: Puspitasari Intan , Hidayat Muhammad
Published: May 2023

Kemampuan individu untuk memberikan respon positif atas emosi negatif yang muncul merupakan salah satu indikator dari regulasi emosi. Pengembangan alat ukur regulasi emosi dalam pengasuhan bertujuan untuk mengetahui kemampuan regulasi emosi orangtua. Tujuan dari penelitian ini adalah mengembangkan alat ukur Regulasi Emosi dalam pengasuhan anak usia dini yang didasarkan pada konsep 5 strategi regulasi Gross yaitu situation selection, situation modification, attentional deployment, cognitive change dan response modulation yang valid dan reliabel. Konsep regulasi emosi Gross masih bersifat umum, sehingga perlu diterapkan pada konteks pengasuhan pada anak usia dini supaya dapat digunakan pada orangtua anak usia dini. Subjek penelitian ini adalah 47 orangtua yang memiliki anak berusia 2-7 tahun. Format awal alat ukur ini terdiri dari 60 aitem (30 aitem favorable dan 30 aitem unfavorable). Alat ukur selanjutnya dinilai oleh 5 orang ahli kemudian diuji validitasnya menggunakan teknik aiken V dengan skor bergerak dari 0.650 hingga 0.950. Sedangkan untuk uji reliabilitas analisis dilakukan dengan teknik Alpha Cronbach yang menghasilkan skor 0.933. Format akhir dari alat ukur regulasi emosi dalam pengasuhan anak usia dini ini adalah 35 aitem.
ANALISIS SENTIMEN TERHADAP TWIT MAXIM PADA TWITTER MENGGUNAKAN R PROGRAMMING DAN K NEAREST NEIGHBORS
Authors: Diwandanu Muhamad Trian , Wisudawati Lulu Mawaddah
Published: May 2023

Usaha transportasi saat ini sudah banyak yang berbasis online dalam pelayanannya seperti pemesanan, pembayaran dan pemberian ulasan. Salah satu jasa transportasi online yang sudah ada di Indonesia yaitu Maxim. Masyarakat biasanya memberikan opini mereka terhadap layanan yang diberikan oleh Maxim melalui Twitter. Twit yang ditulis oleh masyarakat pengguna Twitter merupakan sumber data yang valid untuk dilakukan analisis sentimen. Tujuan penulisan ini adalah melakukan analisis sentimen terhadap twit maxim pada Twitter. Metode klasifikasi analisis sentimen pada penulisan ini menggunakan K Nearest Neighbors (KNN) untuk mengklasifikasi data serta Lexicon-Based sebagai penetap sentimen positif, negatif dan netral. Tahapan awal pada analisis sentimen ini yaitu tahap pengambilan data, pre-processing, yang terdiri dari Filtering & Casefolding, perbaikan kata tidak baku, mengubah kata bernegasi, Stopword Removal dan penghapusan spasi berlebih. Setelah itu, dilakukan pelabelan data dan pemberian skor menggunakan metode Lexicon Based. Dataset hasil dari pre-processing dan Lexicon Based digunakan untuk proses klasifikasi menggunakan KNN. Hasil terbaik didapatkan menggunakan data latih 80% sebanyak 702 data dan data uji 20% sebanyak 175 data dengan k=1 dengan akurasi sebesar 95,43%.
QUALITY OF LIFE MEASUREMENTS FOR PATIENTS WITH CHRONIC SUPPURATIVE OTITIS MEDIA IN A TERTIARY CARE CENTRE
Authors: Majeed Dar Younus , Ali Ihsan , Ahmad Rauf
Published: May 2023

Background: Chronic suppurative otitis media (CSOM) is characterized by a persistent chronic otorrhoea from a perforated tympanic membrane and leads to many clinical presentations that include profuse mucopurulent, non-odorous discharge, deafness, tinnitus, depression, anxiety, and social withdrawal. Such clinical manifestations cause a multidimensional decline in Health-related quality of life HR-QOL including (familial, social, psychological, physical, and functional). Methods: In the current study, we administered a prevalidated tool and assessed the quality of life measurements for 54 patients with CSOM in a Tertiary Care Centre from Kashmir a northern region of India. Results: The majority of subjects (~65%) were in the age group of 18-30 years. Males (57%) and rural inhabitants showed a slight predominance (~56% and 59%%). We found that individuals with CSOM present reduced HR-QOL measures. The majority of subjects reported that, ear symptoms were a cause of reduced quality of life in a sizable number of cases with CSOM. We also observed that CSOM affected the routine cleanliness schedules of the patients. Most of the subjects need therapeutic intervention for treating CSOM more than once in the last 6 months. Conclusion: Given the paucity of data in theeld more replicative studies are warranted to have a better understanding of the reduced HR-QOL of patients with CSOM and its use as an outcome measure for therapeutic interventions.
“ASSESSMENT OF SOFA VS QSOFA VS DELTA SOFA IN ICU PATIENTS”
Authors: D Rajput Saraswati , Kumar Paliwal Sanjay
Published: May 2023

Objective: Ÿ To study the demographic prole of patients with sepsis and multiple organ dysfunction syndrome in patients with intensive care units. Ÿ To evaluate the use of SOFA Score for predicting the mortality in patients with severe sepsis. Ÿ To evaluate the use of MAX SOFA and DELTA SOFA for assessing the outcome of patients with severe sepsis. Materials and Methods: A sample of 100 patients who were admitted to intensive care units and fullled the inclusion criteria were selected for this study from the tertiary care hospital, between September 2021- September 2022 with suspected/conrmed sepsis. It was a prospective observational study. Results: SOFA Score at 48 hours, 96 hours, max SOFA, Δ SOFA showed mortality with a P-value of <0.001 which is statistically signicant. Hence, use of SOFA score, Δ SOFA score, and MAX SOFA score are good predictors of outcomes in patients with sepsis. Conclusion: Sequential assessment of organ dysfunction during the rst few days of ICU admission is a good indicator of prognosis. SOFA score at 48 hours and MAX SOFA score, as well as Δ SOFA score, are useful predictors of the outcome as compared to SOFA score at admission
Biosecurity in Nigeria: Emergence of the National Biosecurity Policy and Action Plan 2022-2026
Authors: Onwude J. , Nwosu O. , Ebegba R.
Published: May 2023

Nigeria has experienced its own share of biosecurity challenges, as evident in its exposure to some disease epidemics and pandemics. Significant outbreaks of diseases may cause devastation to humans and animals, as well as have severe economic, environmental and social impacts. Considering the multi–sectoral nature of biosecurity and the need to explore a coordinated approach to biosecurity, the National Biosecurity Policy and Action Plan 2022–2026 was developed with the aim of fostering the integration and harmonization of biosecurity strategies that will be implemented through the One–health approach for the prevention, early detection, rapid response to biothreats and recovery from biosecurity incidents. The policy document highlights Nigeria’s biosecurity priorities, Institutional Governance and Stakeholders’ Commitment, strategies and action plans, as well as a monitoring and evaluation framework to ensure a strong national biosecurity system. Ensuring biosecurity is a critical sector of a nation’s sovereignty towards ensuring the safety of lives of its citizens and the environment and improving the socio economic development of the country.
COVID-19 Vaccine: A Right or Privilege for Nigerian Prison Inmates
Authors: Subair M.O.
Published: May 2023

Citizens are members of a particular country who, because of birth, registration, or application, are entitled to enjoy certain basic rights and privileges. Discrimination by reason of age, ethnicity, religious background, or liberty of any person should not be entertained at any level; hence, every citizen is to be treated equally in terms of the enjoyment of basic rights and privileges. The most important fundamental right to be enjoyed by a citizen is the right to life, mainly because a person needs to be alive to enjoy other rights and privileges as contained in the constitution. However, the right to life is not limited to the right not to take a person’s life, and rather it expands to the right to enjoy unhindered access to resources that will ensure good physical and mental well–being. Unfortunately, some countries are unable to ensure the enjoyment of these rights by all their citizens. In a bid to manage the limited resources, some persons are being discriminated against, one of which is inmates who are incarcerated and serving an imprisonment term. This act of discrimination was evidenced in 2020 during the COVID–19 pandemic when immediate preventive measures were taken across the country to curb the spread of the virus. It became a cause of concern whether inmates in correctional centres were equally carried along on these measures. This article will discuss the right to life of prisoners in Nigerian correctional centres as it relates to their unhindered right to health. Using the doctrinal and empirical method, this paper will identify the local and international instruments that provide for the enjoyment of the right to health of inmates, and particularly whether inmates were discriminated against in the exercise of the various preventive measures taken during the pandemic.
Infrastructure Reform in Africa: What has happened and what is to be done?
Authors: Afeikhena Jerome
Published: May 2023

This study appraises the record of infrastructure reform in Africa. The results of two decades of regulatory reforms, implementation of the privatization and liberalization agenda, combined with the influx of private investment in infrastructure, have decidedly been mixed. In spite of modest achievements in network coverage and access to services especially in telecommunications, there has been a wide gap between popular perception and the reality on ground. There is now a significant base of experience around the world from which lessons can be learned. Infrastructure privatization should be viewed as a means to an end, and not an end in itself. The goal should be a more efficient, quality, service-delivery sector, that is fulfilling its social responsibilities. Privatization is only an effective means of achieving this goal in the context of appropriate market and regulatory frameworks.
Managing Farmer-Herder Conflicts in Ghana’s Volta Basin
Authors: Tonah Steve
Published: May 2023

Farmer-herder conflicts have become rather widespread throughout West Africa and constitute a threat to peace and stability in many countries. This paper examines the management of farmer-herder conflicts in the Volta basin of Ghana. Using information gathered from five communities through the use of participant observation, interviews and focus group discussions, the paper describes the increasing migration of farmers, herders, fishermen and traders into the Volta basin area. The increasing population has accentuated conflicts between farmers and herders as the two groups compete for the use of the resources of the area. The paper also examines in detail the role that the Livestock Farmers Association and other institutions play in mitigating and managing farmer-herder conflicts in the Volta basin.
Wital: A COTS WiFi Devices Based Vital Signs Monitoring System Using NLOS Sensing Model
Authors: Zhang Xiang
Published: May 2023

Vital sign (breathing and heartbeat) monitoring is essential for patient care and sleep disease prevention. Most current solutions are based on wearable sensors or cameras; however, the former could affect sleep quality, while the latter often present privacy concerns. To address these shortcomings, we propose Wital, a contactless vital sign monitoring system based on low-cost and widespread commercial off-the-shelf (COTS) Wi-Fi devices. There are two challenges that need to be overcome. First, the torso deformations caused by breathing/heartbeats are weak. How can such deformations be effectively captured? Second, movements such as turning over affect the accuracy of vital sign monitoring. How can such detrimental effects be avoided? For the former, we propose a non-line-of-sight (NLOS) sensing model for modeling the relationship between the energy ratio of line-of-sight (LOS) to NLOS signals and the vital sign monitoring capability using Ricean K theory and use this model to guide the system construction to better capture the deformations caused by breathing/heartbeats. For the latter, we propose a motion segmentation method based on motion regularity detection that accurately distinguishes respiration from other motions, and we remove periods that include movements such as turning over to eliminate detrimental effects. We have implemented and validated Wital on low-cost COTS devices. The experimental results demonstrate the effectiveness of Wital in monitoring vital signs.
Van volk naar multitude: Burgerschap als topologische praktijk
Authors: Olma Sebastian
Published: May 2023

In de kern duidt de notie van burgerschap op de wijze waarop we tot de politieke gemeenschap behoren, tot de polis. In het Nederlands heeft het woord burgerschap recentelijk de connotatie gekregen van ‘iets dat te maken heeft met migranten en hun integratie in de Nederlandse samenleving’. Dit is in mijn ogen niet alleen patente nonsens, maar ook contraproductief: burgerschap als de manier van behoren tot een bepaalde polis moet daarbinnen van universele toepassing zijn. Als het verwordt tot een begrip dat men slechts toepast op bepaalde marginale groepen binnen een maatschappij, verliest de notie haar betekenis.
Exceptional Location of Hydatidosis: Hydatid Cyst of the Gallbladder: A Case Report
Authors: RABBANI Khalid , YILA Armandaind , BAROUDI Ghita EL , MANSOURI Mohamed Amine EL , AHBALA Tariq , LOUZI Abdelouahed
Published: May 2023

We report two cases of hydatid cyst located in the gallbladder in two adults. Although Morocco remains an endemic area for echinococcosis, this presentation of the disease is rare. The pericyst was closely attached to the liver. A complete pericystectomy followed by cholecystectomy was performed in both cases. Histopathology confirmed the presence of a calcified hydatid cyst of the gallbladder. Perioperative adjuvant medical treatment with albendazole was administered. During the 2-year follow-up, no recurrence occurred.
Treatment of Varicocele in Adults: Surgery versus Embolization: Experience of Mohammed V Military Instruction Hospital
Authors: Abdessamad El Bahri , Nabil Louardi , Aziz lamghari , Youness Boukhlifi , Mohammed Alami , Ahmed Ameur
Published: May 2023

Introduction: Varicocele is a varicose dilatation of the spermatic cord veins, particularly the pampiniform plexus. It is a frequent and benign affection, which may have a harmful effect on spermatogenesis. Aim: Through this work, we will try to compare the efficiency, complications and recurrence after treatment of varicocele in two patients groups: surgery and embolization. Material and Methods: This is a retrospective study that included all patients treated for idiopathic varicocele, symptomatic or associated with abnormalities of the semen analysis, by embolization, between 2016 and 2021, at the Moulay Ismail Military Instruction Hospital. Thirty patients were included. To compare, the last 30 patients treated by surgery (open or laparoscopic) were included in a second group. Patients in the embolization group were treated with coil embolization or sclerosant agent under local anesthesia. We compared the efficiency, complications and recurrence rate after treatment of varicocele in both groups. The statistical analysis was carried out by the epidemiology laboratory of the Faculty of Medicine and Pharmacy of Fes using the Chi test 2 and Anova test. Results: Surgery has a higher success rate than embolization. However, embolization offers many advantages in terms of surgical time (p = 0.001), duration of hospital stay (p = 0.001), lower recovery time, and less long-term complications. Recurrence was found in 4 patients in group 1 and in 2 patients in group 2. In both groups, there was an improvement in semen analysis, with pregnancy occurred in one couple in group 2, and four in group 1. Conclusion: These two treatment methods are effective in the treatment of idiopathic varicocele, but embolization is a faster, less invasive technique with low postoperative morbidity.
A Rare Case of Duodenal Obstruction: Annular Pancreas in a 22 Years Old Patient: Case Report
Authors: Saad Benslimane , Lazrak Mohammed , Zerhouni Ahmed , Souiki Tarik , Mazaz Khalid , Toughrai Imane , Majdoub Karim Ibn
Published: May 2023

Annular pancreas is a rare congenital condition in which a ring of ectopic pancreatic tissue partially or completely surrounds the second part of the duodenum [1]. This Congenital anomaly is usually presented in infants and newborn, rarely in adult life. It can present in a wide range of clinical severities making it difficult to diagnose. CT scan can illustrate the pancreatic tissue encircling the duodenum. Surgery still remains necessary to confirm diagnosis and bypassing the obstructed segment. We report the case of a 22 years old female patient who presented with history of vomiting and weight loss causing a stature weight growth delay, the diagnosis was made by the CT scan. Then the patient was scheduled for a gastroenteroanastomosis. The evolution was favorable.
Neglected Posterior Dislocation of the Proximal Interphalangeal Joint of the 5th Finger by Incarceration of the Volar Plate: About A Case
Authors: Abakka M. , Ouagari H. El , Baidriss Y. , Mekkaoui M. J. , Bouffetal M. , Bassir R. A. , Kharmaze M. , Lamrani M. O. , Berrada M. S.
Published: May 2023

Volar dislocation of the proximal interphalangeal joint phalanx of the fingers is a very rare entity. Indeed, there is still no consensus that specifies the treatment of this injury. The closed reduction external maneuver should always be tried first intention, but it can lead to failure and will be followed by surgical treatment. We report the case of palmar dislocation of the proximal interphalangeal joint phalangeal pure treated by opened and surgical reduction, followed by an arhtorisis by a Kirschner pin size 16.
FAKTOR-FAKTOR YANG MEMPENGARUHI MINAT BERINVESTASI SAHAM DI PASAR MODAL SYARIAH BAGI GENERASI MILENIAL DI MADURA
Authors: Fitriyani Novita Ayu , Herachwati Nuri , Muhtadi Ridan
Published: May 2023

The purpose of this study is to examine or analyze the Factors Influencing Interest in Investing in Islamic Capital Markets for Millennials in Madura. The variables used are Risk, Income and Knowledge level. The Millennial Generation living in Madura who are interested in investing in Islamic Capital Markets is the population of this study. While the sample was chosen using the purposive sampling technique. In selecting this sample, there were 100 respondents from all 4 districts in Madura. The main information used in this investigation came from structured interviews with the help of a questionnaire. Multiple regression analysis is the data analysis used in this study. Whereas the Knowledge Variable is the result of the conclusion that it has a positive and significant effect on Interest in Investing in Shares in the Islamic Capital Market for Millennial Generation in Madura while the Risk and Income Level Variables have a positive but not significant effect on Interest in Investing in Shares in the Islamic Capital Market for Millennial Generation in Madura.

Keywords: Islamic Capital Market; Share; Millennial Generation; Interest; Investation