bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring children’s TikTok cultures in India: Negotiating access, uses, and experiences under restrictive parental mediation
Authors: Sarwatay Devina , Lee Jin , Kaye D Bondy Valdovinos
Published: September 2022

TikTok is a popular platform allowing users to view and make short videos. The platform's embeddedness among youth cultures is key to TikTok’s commercial success, to attract and sustain a diverse array of international users. The discourse around children and social media especially TikTok is laced with technopanics, as is the case in India. Although sparse, literature shows children in India want to explore social media but parental mediation usually follows a restrictive style. Using a qualitative approach and multimodal methods, we unpack how children (10–18 years) in a large Indian metropolitan city use TikTok for self-presentation and creative expression while navigating restrictive parental mediation. This article helps gain in-depth understanding of children’s TikTok cultures in India by foregrounding their voices and contributes to larger scholarship on youth digital cultures by focusing on their: (a) vernacular cultures on TikTok, (b) deliberations on safety and wellbeing, and (c) negotiations regarding agency and resistance.
Funding arts and culture: Everyday experiences and organisational portfolio precarity
Authors: Ashton Daniel
Published: September 2022

This article examines the everyday experiences of arts and cultural organisations in negotiating the UK government and cultural policy priority for funding income diversification. Identifying the challenges of declining public funding and the connected pressures for arts and cultural organisations to be accountable, this article positions income diversification in relation to New Public Managerialism. In doing so, the need to examine the everyday experiences of how arts and cultural organisations engage with and respond to the income diversification priority is established. This article then presents findings from empirical research with arts and cultural organisations under the following three themes: balancing simultaneous sources, managing timelines and working through change. The discussion develops this analysis by identifying portfolio working and precarity as prominent and significant features of organisations’ experiences. Portfolio working is evident in how organisations identify and manage multiple, potential funding sources. Precarity is evident in the uncertainty and instability of managing the multiple funding sources, and in the way that organisations address operational issues of planning and working practices. To conclude, the concept of organisational portfolio precarity is proposed as a way to critically understand the everyday situations and implications of how art and cultural organisations respond to the income diversification priority.
A load-slip model for stud connector in steel-concrete composite structures
Authors: Song Li , Fang Siqi , Cui Chenxing , Yu Zhiwu , Wang Zhichao
Published: September 2022

A new theoretical calculation method for the load-slip curve and the shear stiffness of the stud based on Winkler’s elastic foundation beam theory and deflection differential equation of the stud is proposed. Different stress characteristics of the elastic and plastic zones of the concrete are considered in the proposed method. The accuracy of the theoretical calculation method is validated by the test results. Moreover, the effect of concrete strength, stud diameter, and yield strength on the stud load-slip curve is analyzed. The results show that the proposed model can effectively reflect the change process of the load-slip curve of the test specimen stud connector. The stud diameter, stud yield strength, and concrete strength affect the peak slip, shear stiffness, and shear capacity of stud shear connectors. With an increase in stud diameter, the peak slip, shear stiffness, and shear bearing capacity of the stud are all increased. An increase in the yield strength of the stud increases its elastic slip, peak slip, and shear capacity. Lastly, with an increase in concrete strength, the elastic slip and peak slip of the stud both decrease, whereas the shear stiffness and shear bearing capacity are increased.
Use of Shockwave Intravascular Lithotripsy in Recanalization of Calcified Visceral and Renal Arteries: A Case Report and Update of the Literature
Authors: Spath Paolo , Hamwi Tarek , Stavroulakis Konstantinos , Fernandez-Prendes Carlota , Stana Jan , Tsilimparis Nikolaos
Published: September 2022

Purpose

Calcifications of the visceral and renal arteries lead to chronic mesenteric ischemia and renal artery stenosis, and both open and endovascular treatments can be proposed. Intravascular lithotripsy (IVL) has emerged as a novel technique used in peripheral and coronary interventions.

Case Report

A 73-year-old man presented with chronic postprandial abdominal pain and weight loss. Computed-tomography-angiography (CTA) showed 93% calcified stenosis of the superior mesenteric artery (SMA). The plain old balloon angioplasty (POBA) was affected by immediate recoiling. The patient underwent ShockwaveTM IVL of the SMA via brachial access and stent-graft implantation. At 3-months follow-up, the patient showed symptoms resolution.

Conclusions

The use of Shockwave IVL can be an effective treatment for severely calcified SMA stenosis. A similar approach can be employed in both celiac and renal arteries as reported in 11 cases in literature and herein summarized. Intravascular lithotripsy resulted in high technical success and uneventful follow-up. However, given the small number of patients reported, larger studies are needed to confirm these findings.

Clinical Impact

This article reports a case of recanalization of superior mesenteric artery with heavily calcified lesion treated with intravascular lithotripsy (IVL) with Shockwave™ Intravascular Lithotripsy Balloon (Shockwave Medical Inc., Santa Clara, CA, USA). Beside, for the first time, we summarize the Literature on the use of IVL in the renal and visceral arteries district, providing indications, applications and useful hints for the endovascular treatment of chronic mesenteric ischemia and renal artery stenosis. This preliminary data show straightforward applicability, high technical success, and uneventful follow-up and IVL can be proposed as an useful tool for challenging revascularization of heavily calcified reno-visceral arteries.
Preparation of Hu sheep wool/polyacrylonitrile oxidized fiber flame retardant and sound absorption material
Authors: Ma Shengsheng , Chen Mengying , Liu Lingshan , Dai Chunpeng , Chen Yiren
Published: September 2022

The breeding scale of Hu sheep continues to expand in China. However, due to the low quality of Hu sheep wool and unsuitable for spinning medium and high-grade wool yarn, the purchase price of Hu sheep wool is low and even it is directly discarded. In order to protect the natural resources from being wasted and improve the added value of Hu sheep, the aim of this paper is to develop a needling sound absorption material using Hu sheep wool. The preparation method of mixing polyacrylonitrile oxidized fiber (PANOF) into Hu sheep wool is used, so as to improve the flame retardance of sound absorbing materials. The two fibers are intertwined to form complex channels by needling and milling process, which is advantageous for being a good sound absorbing material. In order to explore the influence of the blending ratio and mixing methods on the sound absorption and flame retardance, the thickness of needled fabrics is set as about 4.8 mm and the surface density is set as about 440 g/m2 in this paper. The results show that the blending ratio of Hu sheep wool/PANOF is 80/20, the sound absorption coefficient is greater than 50% in the middle and high frequency and high frequency. It is a high-efficiency sound absorption material, and its flame retardant performance meets the standard requirements. This research provides an effective way for the use of Hu sheep wool.
Spectral selective composite mask media for personal cooling and efficient PM 2.5 removal
Authors: Lei Yang , Cai Rong-Rong , Lin Rui-Qi , Zhang Li-Zhi
Published: September 2022

Face masks are commonly used to protect an individual’s respiratory system from inhaling fine particulate matter (PM2.5) in polluted air, as well as the airborne pathogens, especially during the ongoing coronavirus disease 2019 (COVID-19) pandemic. However, all conventional masks with anti-PM2.5 function suffer from insufficient facial thermal comfort, particularly in a hot and humid environment. Herein, we demonstrated a novel infrared-transmittance visible-opaque PM2.5 media for radiative cooling utilizing rutile titanium dioxide particle-embedded polyamide 6 (PA6-TiO2). The transmission of visible light and infrared and PM2.5 removal performance of composite media containing a variety of microstructures, such as TiO2 particles of varying sizes, shapes, and contents, were numerically examined to determine the optimal ranges. Then the PA6-TiO2 media was effectively electrospun by controlling the arrangement of fibers and the morphology of TiO2 particles. By transmitting more than 85% of the thermal radiation from the human body and selectively blocking solar irradiance, the developed PA6-TiO2(flower-shaped) media cooled the simulative skin by 10.3°C as compared with commercial masks under strong solar irradiance. Additionally, they demonstrated a high PM2.5 removal efficiency of 95.3%, a low air resistance of 22.5 Pa (at 5.3 cm/s), and a sound water vapor transmission rate of 0.0169 g cm−2 h−1. This study presents an effective strategy for making thermally comfortable anti-PM2.5 masks, which will significantly benefit the public health prevention and control.
Filtration characteristics of composite filter of woven-nonwoven geotextile in tailings ponds
Authors: Liu Sheng , Wang Yuan , Li Guo Dong , Feng Di
Published: September 2022

Nonwoven geotextiles are widely used in tailings ponds for filtration and drainage, but there is a risk of failure of nonwoven geotextile due to physical clogging. In this study, to reduce the clogging of nonwoven geotextile filter in tailings ponds and improve its long-term drainage performance, a layer of woven geotextile is placed between tailings and nonwoven geotextile to form a composite filter of woven-nonwoven geotextile. A series of gradient ratio tests were conducted to study the influence of the aperture of woven geotextile on the filtration characteristics of composite filter. The long-term filtration performance of composite filter was evaluated, and the filtration mechanism of composite filter was revealed. The results show that after adding a layer of woven geotextile with reasonable aperture upon the nonwoven geotextile, the gradient ratio of filter decreased and the flow rate of filter significantly increased. The filtration performance of composite filter of geotextile was better than that of nonwoven geotextile filter. The aperture of woven geotextile had an important influence on the filtration characteristics of composite filter. With the increase of the aperture of woven geotextile, the gradient ratio value of the composite filter decreased first and then increased. For relatively dense tailings, the recommended ratio of the equivalent aperture of woven geotextile (O95) to the characteristic particle diameter of tailings (d85) s is about 1.6.
Cold nitrogen plasma treated glass fiber warp knitted structural composites: mechanical properties and response surface analysis
Authors: Fang Chunyue , Chen Yingcan , Jia Lixia , Yan Ruosi
Published: September 2022

This study reveals the characterization and mechanical properties of glass fiber warp knit structural fabric/vinyl ester resin composites treated by cold nitrogen glow discharge plasma. The effects of nitrogen plasma treating parameters (including power, flow rate, and time) on tensile and bending properties of glass fiber warp knit structural composites were investigated. It was shown that nitrogen plasma treatment enhanced the tensile and bending property of the glass fiber warp knit structural composites. SEM, FTIR and AFM characterized etching existing on the surface, C-N and N-H groups were introduced, and varying degrees of roughness. The response surface analysis represented that the nitrogen plasma treated glass fiber warp knit structural composites obtained optimized bending properties with the power ranging from 130 W to 160 W, the flow rate ranging from 8sccm to 9sccm, and the time ranging from 100s to 110s.
Manganese waste liquid derived MnFe2O4/RGO fabric for microwave blocking, high stable strain and temperature sensing
Authors: Hong Xinghua , Sun Wei , Peng Tao , Qian Junnan , Zhang Zhaofa , Zhu Chengyan , Cai Guangmin
Published: September 2022

Herein, a MnFe2O4/RGO knitted fabric derived from manganese waste was constructed by a simple in-situ assembled coating method, involving the incorporation of Graphene Oxide (GO) and manganese ferrite nanoparticles on polyester fabric, followed reducing by hydrazine hydrate. The reuse of manganese waste from the preparation of GO can reduce chemical waste emissions and endow the absorption performance. The coated particles possess certain magnetism can be attracted and securely collected in seconds, which is convenient for recycling. This fabric gives well microwave absorption with the maximum reflection loss (RL) of −58.6 dB at 9.1 GHz by a thickness of 1.9 mm. In addition, this fabric presents high stable strain sensing under 1000 stretching and bending cycles. Meanwhile, the resistance-deformation-velocity relationship is provided based on the structure, for the analysis of electromechanical behaviors. Moreover, the fabric has the capability for temperature sensing (TCR=−0.738%/°C), and fire alarm. As such, this fabric can be promising alternatives for a wide application on motion and temperature sensing, microwave blocking.
Outcomes of Candida and Non-Candida Aortic Graft Infection
Authors: Omran Safwan , Gröger Steffen , Shafei Bashaer , Schawe Larissa , Bruder Leon , Haidar Haidar , Greiner Andreas
Published: September 2022

Objective

To evaluate and compare the outcomes of Candida- and non-Candida-associated aortic graft infections.

Methods

We retrospectively analyzed the data from patients treated for aortic graft infection from 2015 to 2021 in our hospital.

Results

A total of 66 patients (56 men; median age, 69 years; range, 50-87 years) were admitted with aortic graft infection, including 21 (32%) patients in the Candida group and 45 (68%) in the non-Candida group. The average time between initial operation and presentation of aortic graft infection was 50 months (range, 1-332 months). Graft-enteric fistulas (GEFs) were more often in the Candida group (57% vs 27%, P = .017). The most proven causative fungal specimen was C. albicans in 16 (76%) patients. Non-albicans Candida was found in 9% of all patients and 29% of the Candida patients. The median ICU length of stay was longer in the Candida group than non-Candida (10 vs 9 days, P = .012). Additionally, the median hospital length of stay was longer in the Candida group (33 vs 22 days, P = .048). There were no statistically significant differences between Candida and non-Candida groups according to the in-hospital mortality (24% vs 24%, P = .955), and 1-year mortality (38% vs 38%, P = .980).

Conclusions

Patients with bacterial and fungal aortic graft infections have high rates of morbidity and mortality. We found no significant differences in postoperative morbidity and mortality between Candida and non-Candida patients. However, the ICU and hospital length of stay were longer in the Candida group.
USE of Biodegradable STENTS in Pancreaticoduodenectomy: Initial Experience
Authors: Sulieman Ibnouf , Elaffandi Ahmed , Elmoghazy Walid , Khalaf Hatem
Published: September 2022

Background. Plastic stents have been used to avoid postoperative pancreatic fistula (POPF) following Whipple’s Pancreaticoduodenectomy (WPD), but they may cause some stent-related complications. Biodegradable stents have been recently introduced and might be a safe alternative. Here we present our initial experience with their use. Methods. Between March 1, 2020, and September 30, 2020, ten (10) consecutive patients underwent WPD. They all had conventional two-layer pancreaticojejunostomy with the placement of an internal biodegradable stent. They were assessed for technical feasibility, pancreatic leak, and stent-related complications. Results. The use of biodegradable stents was technically feasible in all patients, despite some difficulties in insertion due to stent stiffness and design. After a median follow-up period of 124 days, none of the patients suffered POPF. One patient had a biochemical pancreatic leak with no clinical significance. The median hospital stay was 7 days, and there were no stent-related complications. Conclusion. Biodegradable stents are technically feasible and safe in WPD with good short-term outcomes. They might provide a better alternative to plastic stents and their potential complications. Larger long-term studies are needed to validate efficacy and safety. Few modifications of the stent’s design might be needed to facilitate use in open surgery.
Mechanical thrombectomy using the Nimbus stent-retriever – initial experiences in a single-center observational study
Authors: Boriesosdick Jan , Michael Arwed Elias , Kröger Jan-Robert , Niehoff Julius Henning , Saeed Saher , Pflug Marc , Schellinger Peter , Maus Volker , Borggrefe Jan , Mönninghoff Christoph
Published: September 2022

Background

The Nimbus stent-retriever (NSR) was developed for mechanical thrombectomy of wall-adherent thrombi in cerebral arteries. It features a novel geometry with a proximal spiral section and a distal barrel section. The new device is designed to retrieve tough clots with a micro-clamping technique. In the first case series reporting on the NSR, we share our initial experience about the first 12 treated cases.

Methods

In total, 12 patients (5 men, 7 women; mean age 78 years) with occlusion of the internal carotid artery or the middle cerebral artery (M1 or M2 segment) were treated with the NSR, 11 after unsuccessful recanalization attempts with conventional stent-retrievers or aspiration thrombectomy.

Results

Retrieving maneuvers with the NSR recovered a thrombus in 7 patients (58%), of which 6 resulted in vessel recanalization mTICI ≥ 2b. Successful recanalization improved the mTICI score by a median of 3 points. In 5 of 7 cases, this required only one thrombectomy maneuver. In 5 cases, no improvement of recanalization could be achieved with the NSR (1–3 attempts). No NSR-related complications occurred in this case series.

Conclusions

In our initial experience, the NSR appeared to be a safe and effective second-line stent-retriever after unsuccessful MT with conventional stent-retrievers or aspiration thrombectomy allowing for mTICI ≥ 2b rescue thrombectomy in ab 50% of cases. No NSR associated complications occurred in our case series.
“We don’t talk about it enough”: Perceptions of pelvic health among postpartum women in rural communities
Authors: Snyder Kailey , Mollard Elizabeth , Bargstadt-Wilson Kari , Peterson Julie
Published: September 2022

Purpose:

A descriptive qualitative study was conducted to explore perceptions and experiences related to pelvic health in the postpartum period among a cohort of women residing in communities with less than 50,000 residents.

Methods:

A semi-structured interview approach guided by the Theory of Planned Behavior was used. Postpartum individuals (<6 months since childbirth) were interviewed in the fall/winter of 2021–2022.

Results:

Specific to individuals’ attitudes toward pelvic health, women viewed Kegels as an important component to improving pelvic health but had a negative attitude toward their own pelvic health, often identifying their pelvic floor as “weak.” The subjective norms influencing a woman’s perception were typically, a positive influence by family/friends and the Internet, although the Internet was viewed as an insufficient resource. Healthcare providers were noted as an infrequent and ineffective resource for education and support in the postpartum period. Finally, women’s perceived behavioral control to manage their pelvic health was influenced by limited knowledge of pelvic health and time, and a desire for more education from their primary care provider and geographical barriers.

Conclusion:

Innovative strategies are needed to support postpartum women’s pelvic health within rural communities. Primary care providers may benefit from the development of “quick tips” by specialists, such as women’s health physical therapists, to optimize pelvic health discussions with their postpartum patients. Education interventions targeted toward postpartum women in rural communities should focus on strategies that address the geographic barriers identified while still providing individualized care. Options, such as webinars, telehealth, and text message interventions, could be considered.
Intravenous thrombolysis for treatment of pediatric acute ischemic stroke: Analysis of 20 years of population-level data in the United States
Authors: Dicpinigaitis Alis J , Shapiro Steven D , Nuoman Rolla , Kamal Haris , Overby Philip , Kaur Gurmeen , Chong Ji Y , Fifi Johanna T , Dangayach Neha , Miller Eliza C , Yaghi Shadi , Al-Mufti Fawaz
Published: September 2022

Background and Aims:

Although intravenous thrombolysis (IVT) represents standard-of-care treatment for acute ischemic stroke (AIS) in eligible adult patients, definitive evidence-based guidelines and randomized clinical trial data evaluating its safety and efficacy in the pediatric population remain absent from the literature. We aimed to evaluate the utilization and outcomes of IVT for the treatment of pediatric AIS using a large national registry.

Methods:

Weighted hospitalizations for pediatric (<18 years of age) AIS patients were identified in the National Inpatient Sample during the period of 2001 to 2019. Complex sample statistical methods were performed to assess unadjusted and adjusted outcomes in patients treated with IVT or other medical management.

Results:

Among 13,901 pediatric AIS patients, 270 (1.9%) were treated with IVT monotherapy (median age 12.8 years). IVT-treated patients developed any intracranial hemorrhage (ICH) at a rate of 5.6% (n = 15), and 71.9% (n = 194) experienced favorable functional outcomes at discharge (to home or to acute rehabilitation). Following propensity-score adjustment for age, acute stroke severity, infarct location, and etiological/comorbid conditions, IVT was not associated with an increased risk of any ICH (5.6% vs 5.4%, p = 0.931; adjusted odds ratio (aOR) = 1.01, 95% confidence interval (CI) = 0.48–2.14, p = 0.971), nor with favorable functional outcome (71.9% vs 74.5%, p = 0.489; aOR = 0.88, 95% CI = 0.60–1.29, p = 0.511) in comparison with other medical therapy.

Conclusions:

Twenty years of population-level data in the United States demonstrate that pediatric AIS patients treated with IVT experienced high rates of favorable outcomes without an increased risk of hemorrhagic transformation.
Functional healthy state evaluation approach based on phased state task network for intelligent multistation manufacturing systems
Authors: Wang Wenzhuo , Zhao Yu , He Yihai , Yang Xiuzhen , Zhang Jishan
Published: September 2022

The core function of the intelligent multistation manufacturing system is to continuously and stably output a specified number of qualified products which can meet the requirements of production tasks through the machine at each station. Consequently, only the analyzing and modeling of the physical failure of the machine cannot realize the functional healthy state evaluation of the manufacturing system oriented to product quality, nor can it describe the phased degradation characteristics during the task execution. Therefore, a novel evaluation approach of the functional healthy state based on phased state task network (PSTN) theory for the intelligent multistation manufacturing systems is proposed in this study. First, the connotation of a functional healthy state of the intelligent multistation manufacturing system is expounded in combination with the performance state of each component in the system from the perspective of system engineering. Second, the PSTN of the intelligent multistation manufacturing system is established, and an integrated mission reliability model of the system is built on it. Third, a functional healthy state evaluation approach is proposed on the basis of the integrated mission reliability model and fuzzy evidence theory. Finally, a cylinder head manufacturing system is taken as an example to verify the proposed method, and sensitivity and comparative analyses are carried out to illustrate its effectiveness and advantages.
Is it Worth the Risk? Grievances and Street Protest Participation During the COVID-19 Pandemic in Chile
Authors: Donoso Sofía , Puga Ismael , Moya Cristóbal , Gerber Monica M.
Published: September 2022

The COVID-19 pandemic started in Chile as the country was experiencing massive protests and a deep political crisis. Sanitary measures restricting movement and gatherings were implemented while the process of constitutional change responding to this crisis developed. In this context of conflict, we study why people continued participating in street protests despite the restrictions and the health risks involved. Using two surveys, we test key factors addressed in extant scholarship: biographical availability, perceived risks, and grievances. We find that grievances related to the pandemic were the most important factor, while biographical availability was much less relevant in the pandemic context. There is no evidence that perceived health risks mattered when deciding whether to join a street protest or not. These results suggest that under conditions of political crisis, grievances related to the administration of the pandemic can motivate political participation even when the latter put people's health at risk.
Rutin Suppresses DMBA Carcinogenesis in the Breast Through Modulating IL-6/NF-κB, SRC1/HSP90 and ER-α
Authors: Youssef Seham S M , Ibrahim Nashwa K , El-Sonbaty Sawsan M , El-Din Ezz Magda K
Published: September 2022

Rutin dietary supplements may offer pharmacological benefits as anticancer and antiinflammatory properties. This study aimed to investigate the inhibitory and protective effect of rutin on signaling pathways of mammary gland carcinogenesis expermintally induced in female rats by 7,12-di-methyl benz (a) anthracene (DMBA). Results showed that rutin administration ameliorated DMBA toxicity and carcinogic effect on kidney and liver revealed by a significant decrease of urea and creatinine levels, and the activity of the liver enzymes alanine aminotransferase (ALT) and alkaline phosphatase (ALP). The antioxidant state indicated by the total antioxidant capacity (TAC) was significantly increased accompanied by a reduction in the inflammatory markers of interleukin-1β (IL-1B), interleukin-6 (IL-6), and tumor necrosis factor (TNF-α) with induction of apoptosis indicated by a significant increase in caspase-3 level. Rutin significantly reduced the levels of the tumor markers carcinoma antigen 15-3 (CA 15-3) and proto-oncogene tyrosine-protein kinase Src1 (Src1). along with downregulation of nuclear factor-kB (NF-κB), heat shock protein 90 (HSP 90), and inducible nitric oxide synthase (iNOS) gene expression. The present study demonstrated the beneficial anticancer activity of rutin as a protective and therapeutic agent. Rutin induces its antitumor activity through elevation of the antioxidant state, inhibition of inflammatory cytokines, downregulation of oncogenes expression, and stimulation of apoptosis.
The Pandemic as a Soundtrack for the Dissertation Journey: Obtaining Flow During Unprecedented Times
Authors: Ralston Nicole C. , Smith Rebecca
Published: September 2022

The purpose of this mixed methods study was to investigate the experiences of practitioner-scholars as they conducted their dissertations amidst the COVID-19 pandemic; the methodology utilized surveys at four time points across a 1-year span. Findings indicated increased impacts as the pandemic progressed, as well as both negative and positive pandemic impacts related to flow, as measured by the Work-Related Flow Inventory (WOLF). These impacts largely depended on the doctoral students’ personal and work life situations, indicating a need for doctoral programs to provide individualized support as students progress through their dissertation journeys, particularly during times of crisis.
Raising awareness: The implementation of medical cannabis and psychedelics used as an adjunct to standard therapy in the treatment of advanced metastatic breast cancer
Authors: Zafar Rayyan , Sulak Dustin , Brambila Jaime , Nutt David , Schlag Anne
Published: September 2022

A 49-year-old woman was diagnosed with an ER + , PR-, HER2 + , BRCA- invasive ductal carcinoma which progressed metastatically to include bone, liver, and lymph node involvement. Standardised care included a 26-month treatment period with targeted chemotherapy and a ketogenic diet. The patient also began a course of cannabinoid-based therapy, consisting initially of a titrated high-dose protocol of mixed cannabidiol (CBD) and d9-tetrahydrocannabinol (THC) chemotypes, as well as psilocybin-assisted psychotherapy at macro and intermittent micro-doses. At the end of the five-month treatment period PET/CT investigations revealed no evidence of metastatic disease and chemotherapy was withdrawn. A one year follow up CT investigation concluded no evidence of residual or recurrent disease. A recurrence of disease was noted at 18 months follow up. Over these 18 months the cannabis regimen was titrated down to 60% of the initial protocol. This was subsequently increased to the initial dosing protocol following detection of recurrent disease and this titration occurred over a 10-month period where it remained stable. 16 months following the detection of recurrence of disease, favourable results were observed in the patient with evidence of receding cancer progression. Over the last 15 years there has been a considerable body of in-vitro and in-vivo evidence supporting the anti-neoplastic properties of cannabinoids and more recently psychedelics. Indeed, growing anecdotal and real-world evidence is reported of the therapeutic effect of cannabinoids and psychedelics in reducing both tumour proliferation and aiding as a palliative medicine to treat pain and psychological distress associated with cancer and chemotherapy. The data presented here indicate the potential therapeutic utility of such adjunctive pharmacological interventions in an individual with metastatic breast cancer.
A comparative study of the harms of nitrous oxide and poppers using the MCDA approach
Authors: Ferreira Plinio M , Winstock Adam R , Schlag Anne Katrin , Brandner Brigitta , Henderson Graeme , Miller Ian , van Amsterdam Jan , Phillips Lawrence D , Taylor Polly , Gittins Rosalind , Rolles Steve , Brink Wim van den , Nutt David
Published: September 2022

The recent surge in recreational (non-medical) use of nitrous oxide (N2O, also known as ‘laughing gas’) often by inhaling it from balloons, has attracted the attention of some politicians with calls to control its possession under the United Kingdom (UK) Misuse of Drugs Act 1971 (currently selling, but not possession, for recreational use is controlled under the Psychoactive Substances Act 2016). Meanwhile, the recreational use of nitric monoxide (NO) as delivered by alkyl nitrites, also known as ‘poppers’ has also raised concerns, but unlike N2O, its use was not controlled under the 2016 Act.

To inform future-decision making processes and ensure that any such decisions are based on the best evidence, Drug Science conducted a Multi-Criteria Decision Analysis (MCDA) about N2O and poppers to compare the overall harms of these two drugs to the harms of 20 drugs previously evaluated and published by Nutt et al.

The group assessed harm scores for N2O and poppers on the original 16 harm criteria using the associated 0 to 100 scales, on each of which 100 had been assigned to the most harmful drug and zero to the least harmful, though that often meant no harm.

On the overall harm scale, N2O scored 6, just above magic mushrooms (psilocybin) while ‘poppers’ scored 5. Together these are the three lowest drugs on the overall harm scale. Although their overall scores are similar, the reasons behind the ratings differ. Nitrous oxide was considered more harmful than poppers for Dependence, Environmental Damage, Drug Related Relative Impairment of Mental Functioning, and Family Adversities, while poppers are more harmful than N2O for Injury, Drug Related Damage, Economic Cost, and Drug Related Mortality.

When assessing the risk different substances may hold when making policy decisions, it is important to acknowledge the relative contribution of these diverse harms within different domains.
Promoting the scientific spirit and ideas: How to realize the guiding role of scientific culture based on the modern science and technology museum system
Authors: Liu Xuan , Ren Peng
Published: September 2022

In the context of the publication of the National Action Plan for Scientific Literacy (2021–2035) and the 14th Five-Year Plan for the Development of the Modern Science and Technology Museum System (2021–2025), and based on a review of the history and characteristics of various science popularization venues, this paper analyses the mission of those venues in advocating scientific methods, disseminating scientific ideas and promoting the scientific spirit and the scientist spirit. It discusses the requirements for science popularization venues to strengthen scientific culture. Finally, the paper provides suggestions for fulfilling the guiding role of scientific culture through promoting the modern science and technology museum system, including enhancing strategic awareness, strengthening academic research and breaking disciplinary barriers.
Lexical Profile of Academic Written English Revisited: What Does it Take to Understand Scholarly Abstracts?
Authors: Nguy Nhu Le Quynh , Ha Hung Tan
Published: September 2022

The abstract is an integral part of a scientific paper. Despite the importance of abstracts, very little research has investigated the vocabulary size needed to read abstracts in scientific papers. This present study analyzed the lexical profile of 26 million words from approximately 100,000 scholarly abstracts across 10 major subjects of science. The results showed that the vocabulary size of the most frequent 7,000 and 15,000 word families in the British National Corpus/Corpus of Contemporary American English (BNC/COCA) word list plus proper nouns, marginal words, transparent compounds, acronyms were needed to gain 95% and 98% coverage of the abstract corpus, respectively. However, data from cross-disciplinary analyses demonstrated significant differences in the lexical demands between abstracts of different fields of study. The 570 word families in the Academic Word List were found to make up for 13.77% of the words in the corpus. Implications for the use of abstracts in language classrooms were discussed.
Li-doped calcium phosphate cement for accelerated bone regeneration of osteoporotic bone defect
Authors: Lu Chengwu , Wang Linfeng , Zhang Libao , Xue Chaghui , Ye Hong , Chen Xiaojie , Wu Jianbin , Xiao Jin
Published: September 2022

Osteoporotic fractures seriously endanger the elderly quality of life, especially postmenopausal women. Currently, calcium phosphate cement (CPC) is one of the materials used for the treatment of osteoporotic fractures. This study intends to investigate the biological effects of lithium (Li)-doped CPC. Li was dissolved into ultrapure water as curing solution to prepare CPC@Li composite material. Li did not affect the morphology of CPC. CPC@Li composite showed a sustained release of Li in 14 days. Compared with CPC, CPC@Li promoted the adhesion, proliferation, and osteogenic differentiation of rat bone marrow stem cells. The result of femur implantation in an osteoporosis mouse model showed that a larger amount of new bone was formed surrounding the CPC@Li implant and closely to the implant surface, indicating favorable osteogenesis and osteointegration capabilities. Li-doped CPC is promising to be used in clinic for its enhanced bone regeneration ability.
People Analytics Enabling HR Strategic Partnership: A Review
Authors: Suri Neha , Lakhanpal Pooja
Published: September 2022

For more than two decades, academicians and practitioners have been theorising the role of people analytics in enhancing the efficiency, effectiveness and impact of the human resource (HR) management function, thereby prescribing people analytics as an enabler of HR strategic partnership. The objective of this study is to identify and synthesise existing literature on people analytics and its conceptualised efficacy. This is done with a view to assess how and why people analytics enhances HR as a field and elevates it to a function of strategic significance. The study uses the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) framework for systematic literature review to address the research objective. A total of 90 articles on the subject are identified majorly from Scopus. The analysis of this literature reveals four significant themes underscoring the role people analytics can play in enabling HR as a field and function. These include the following: (a) application of people analytics leads to greater vertical, horizontal and external alignment of the HR function; (b) people analytics facilitates better integration of HR management with the organisation’s strategic planning process; (c) people analytics aids the demonstration of causal links between HR management and business performance; and finally (d) people analytics endows the field with scientific rigour, consistency and resulting credibility. The study contributes to the existing knowledge on people analytics and HR strategy linkage by building a foundation and offering specific propositions for empirical enquiry relating the two. The significance of the study also emanates from its focus on the efficacy of people analytics which is being viewed as an HR approach with immense potential.
“Not Nearly as Bad”: Social Comparisons and the Debt Experience
Authors: Bryer Ellen
Published: September 2022

Despite the growing awareness of the role that families play in the experience of student borrowing, debt is still understood as a private experience. As student debt becomes more widespread, individuals are increasingly likely to know others with student loans, yet questions remain about how others—friends, acquaintances, and colleagues—may shape the way student borrowers make sense of their debt. This study draws on interviews with recent master’s degree recipients to examine how young adults understand their educational debt in relation to others. The author finds that borrowers are enmeshed in “debt dense” social networks that both normalize debt and facilitate evaluative social comparisons against others that accentuate borrowers’ own efforts and responsibility. These findings demonstrate a role for occupational and educational social networks in shaping borrowers’ experience of indebtedness but also suggest limits to framing student debt as a collective problem.
In Search of Transformative Ways of Being in Mission: Introducing the Mission Spirituality Spiral
Authors: Lepori Laura , Karecki Madge
Published: September 2022

This article reflects on the interface between missiology (and mission) and spirituality (including spirituality in practice). It explores the relationship between the two disciplines and introduces the mission spirituality spiral, which can be used both as an analytic and as a mobilizing tool. Mission and spirituality are explored at their core. Their cohesiveness and inseparability lead to the notion of mission spirituality, which takes shape in the mission spirituality spiral. The article explains the dimensions of the spiral, which flow one into the other and culminate in the discernment of transformative ways of being in mission.
Theologies of Fulfillment in a Reciprocal Study of Relationships between John Laughton and Rua Kēnana in Aotearoa New Zealand
Authors: Taylor Steve
Published: September 2022

Crossing the borders of religion presents challenges and provides opportunities. This article presents a contextualized case study from Aotearoa New Zealand, examining the lifelong relationship between Presbyterian missionary Rev. John “Hoani” Laughton (1891–1965) and Māori leader Rua Kēnana (1869–1937). Photography, as a tool in discerning lived theologies, suggests a side-by-side relationship of reciprocity and particularity. Relationships across differences are revealed not in theory but in lived practices of education, worship and prayer, life and death. The argument is that Kēnana and Laughton enacted theologies of fulfillment, grounded in different epistemologies: mātauranga Māori and Enlightenment thinking.
What Has Jerusalem to Do with the Internet? World Christianity and Digital Culture
Authors: Chow Alexander
Published: September 2022

This article was originally presented as the keynote address at the 2021 Yale-Edinburgh Conference, on the theme “Oral, Print, and Digital Cultures in World Christianity and the History of Mission.” It highlights the rise of digital technologies and the resultant development of digital culture—a culture that scholars of World Christianity are among the most well-suited to study. The article offers vignettes into different ways the Christian message has been translated into digital media and argues that this move transforms the digital space into a divine space, which offers new modes for people to experience, perceive, and practice the Christian religion.
FOXP2 down expression is associated with executive dysfunctions and electrophysiological abnormalities of brain in Autism spectrum disorder; a neuroimaging genetic study
Authors: Haghighatfard Arvin , Yaghoubi asl Elham , Bahadori Rosita Azar , Aliabadian Rojina , Farhadi Mahdi , Mohammadpour Fatemeh , Tabrizi Zeinab
Published: September 2022

Background and aims

Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by language impairment, and challenges with social interaction, communication, and repetitive behaviors. Although genetics are a primary cause of ASD, the exact genes and molecular mechanisms involved in its pathogenesis are not completely clear. The FOXP2 gene encodes a transcription factor that is known for its major role in language development and severe speech problems. The present study aimed to evaluate the role of FOXP2 in ASD etiology, executive functions, and brain activities.

Methods

In the present study, we recruited 450 children with ASD and 490 neurotypical control children. Three domains of executive functions (working memory, response inhibition, and vigilance) were assessed. In addition, five-minute eyes closed electroencephalography was obtained from some of the children with ASD and neurotypical children. DNA sequence and expression level of FOXP2 in blood samples of children with ASD and the control group were evaluated by using sequencing and Real-time PCR, respectively.

Results

The results showed no mutations but a significant down expression of FOXP2 genes in children with ASD vs. neurotypical children. Several cognitive and executive function deficiencies were detected in children with ASD. Low alpha and gamma bands in the frontal lobe and high theta bands in the occipital lobe were revealed in children with ASD. We also found several correlations between FOXP2 expression levels and clinical assessments.

Conclusions

Our finding revealed the down expression of FOXP2, which could be considered as a biomarker for ASD as well as cognitive and executive dysfunction. Based on brain mapping data, FOXP2 may be related to the theta wave abnormality of children with ASD. FOXP2 may be considered a target of novel treatment to improve memory and executive functions.

Implications

Our findings highlight the role of FOXP2 mRNA level in ASD etiology, executive functions, and brain wave frequencies.
Retrospective Review on Role of Neck Dissection in Laryngectomy of Patients With N0 Laryngeal Carcinoma
Authors: Wong Stephanie Nga‐sze , Lau Felix Tak‐yin , Chung Joseph Chun Kit , Tsang Raymond King‐yin
Published: September 2022

Objectives

The primary objective is to evaluate the incidence of occult nodal metastasis in patients undergoing total laryngectomy with cN0 disease. Other objectives are to compare the survival between different treatments of the neck, identify possible associated risk factors, and evaluate the effectiveness of elective neck dissection in this population with regards to oncological outcomes.

Study Design

Retrospective review.

Setting

Tertiary hospitals in Hong Kong.

Methods

Retrospective study was performed on patients who underwent total laryngectomy from 2008 to 2017 in New Territories West and Hong Kong West Clusters of the Hospital Authority of Hong Kong as primary or salvage treatment for cN0 squamous cell carcinoma (SCC) of the larynx. Incidence of neck dissection, incidence of nodal involvement, possible predictors, and oncological outcomes were analyzed.

Results

Seventy‐seven patients were included, of whom 61 underwent either ipsilateral or bilateral neck dissection. Most (90.1%) of the patients with total laryngectomy done had locally advanced disease. Overall occult nodal metastasis rate was 20.6%, and only 3.8% of them had contralateral nodal metastasis. Occult nodal metastasis was significantly less in salvage laryngectomy (P =. 045), while midline involvement and pT3/4 disease seem to be predictors for contralateral nodal metastasis.

Conclusion

There is significantly lower incidence of occult nodal metastasis in cN0 laryngeal SCC in the salvage setting, and occult contralateral nodal metastasis is not common in the cohort. Neck dissection during a salvage laryngectomy for cN0 disease could be avoided while contralateral neck dissection might be considered in cases of locally advanced disease with midline involvement.
Attachment of young foster children
Authors: West Delphine , Van Holen Frank , Verheyden Camille , Gypen Laura , Vanderfaeillie Johan
Published: September 2022

Family foster care is the option of choice in case of out-of-home placements in Flanders, resulting in rising numbers of family foster care placements. As a number of the foster children experienced traumatic events and all of them were separated from their primary caregivers, concerns can be raised about the quality of attachment between foster children and their foster carers. Additionally, international research regarding associated factors with attachment quality is scarce and inconclusive and to our knowledge, Flemish research into this matter was non-existent. The sample of this research consisted out of 68 young foster children and their foster mothers. The attachment behavior was scored by the foster mothers on the Attachment Insecurity Screening Index. The mean for the total Attachment Insecurity Screening Index was non-clinical, but significantly higher than the mean of the norm group, this points to foster mothers perceiving more insecure attachment behavior in the relationship with their foster children. The rates for insecure attachment were comparable to the regular population. Parenting stress and problem behavior were positively associated with insecure attachment scores and, negatively with self-reported sensitivity of foster mothers. These factors were entered in a multiple linear regression model. This model shows that higher levels of parenting stress and more behavior problems were associated with higher insecure attachment scores. We recommend to pay sufficient attention to the attachment relationship of foster children and their foster carers, parenting stress and behavior problems by monitoring them regularly and providing additional support and interventions when these are indicated.