bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation of Lycium barbarum Active Glycopeptide and Investigation of Its
Apoptotic Effects on Melanoma
Authors: Qi Jinghua , Qi Xingli , Chen Hongyuan , Rui Wen
Published: November 2023

Introduction:

The increasing number of studies have shown that Lycium barbarum polysaccharides
possess anti-tumor effects. However, the determination of the active ingredients and their mechanism against
melanoma inhibition are still unknown.

Methods:

In this study, we aimed to investigate the mechanisms of action of Lycium barbarum active glycopeptide
(LBAG) on melanoma. LBAG was extracted and isolated from the fruit of Lycium barbarum using aqueous
alcoholic precipitation and identified using ultra-performance liquid chromatography-quadrupole-time of flightmass
spectrometry. Various assays including cell apoptosis, cell cycle analysis, colony formation assay, cell
scratch test, flow cytometry, and Western blot were performed to evaluate the effects of LBAG on melanoma.

Results:

The results showed that LBAG has a molecular weight of 10-15 kDa and contains Man, Rha, GlcA, Glc,
Gal, and Ara18 amino acids. Treatment with LBAG significantly decreased B16 cell proliferation and induced
cell cycle arrest at the G0/G phase, accompanied by the accumulation of reactive oxygen species. Western blot
analysis revealed that the phosphorylation of P38-MAPK and AKT, as well as the expression of N-acetyl-Lcysteine,
were related to cell apoptosis and cell cycle regulation. In mouse xenografts, LBAG inhibited tumor
growth through the P38-MAPK and AKT signaling pathways.

Conclusion:

In conclusion, the anti-melanoma activity of LBAG may induce apoptosis in cancer cells through
ROSmediated activation of the P38-MAPK and AKT signaling pathways. These findings provide a foundation
for further research on the anti-melanoma potential of LBAG.
Spontaneous Intracranial Hemorrhage and Acute Respiratory Distress
Syndrome Associated with Dengue: A Case Report
Authors: Singh Jitendra , J. Bhavya , Dinkar Anju , Kumar Nilesh , Kumar Kailash , Singh Santosh Kumar
Published: November 2023

Background::

Dengue is a major health burden worldwide, notably in tropical and subtropical
countries, with symptoms ranging from asymptomatic infection to severe hemorrhagic or shock
syndrome. The clinical and biochemical profile of dengue has been shown in the literature to be
expanding as more atypical signs have been added over the past few decades. Most dengue-related
symptoms are typically mild to moderate and self-limited. However, intracranial hemorrhage and
acute respiratory distress syndrome in severe dengue is an event that has been encountered uncommonly.

Case presentation::

A 30-year-old female presented with complaints of fever, headache, cough, and
altered sensorium. Later, she was diagnosed with severe dengue fever complicated by dengue hemorrhagic
fever, which manifested as subarachnoid and subdural bleeding and acute respiratory distress
syndrome. She was managed conservatively with a positive outcome.

Conclusion::

Atypical manifestation, though rare, should be kept in mind while dealing with severe
dengue patients, as early detection based on anticipated risk factors and timely treatment have the
potential to save lives.
An Overview of Biosynthetic Pathway and Therapeutic Potential of Naringin
Authors: Goyal Jugnu , Goyal Rishab , Kumar Verma Prabhakar
Published: November 2023

Naringin is a naturally obtained chemical from plants that is formed as a secondary metabolite in them. It possesses significant properties that are
useful to humans. The primary sources of naringin extract include fruits of the citrus family which are Citrus reticulata, Citrus bergamia, Citrus
aurantium, and Citrus paradisi. It belongs to a class of alcohols primarily consisting of a fused ring system which is responsible for its different
medicinal properties, as a consequence, it is widely used in the nutraceutical market nowadays. Nutraceuticals are a part of food that provides
health benefits by giving supplements to the body; their final extract form is white in color having crystalline properties with a melting point of
83oC and solubility of 1 mg/ml at 40oC. The absorption of nutraceuticals occurs inside the stomach as it requires a specific pH range between
3.5-4.2. After absorption, it gets converted into naringenin in the liver via a cascade of reactions like dehydrogenation, acetylation, and hydrolysis.
Several enzymes are responsible for its conversion into an active form which includes cytochrome P-450, and chalcone isomerase. Its
bioavailability depends on a variety of factors including disease condition, gastric moiety, pH of absorption site, the presence of other drugs, and
many more. It gets metabolized in the liver itself and finally excreted in the urine. It can be tolerated by the body at high doses, but other conditions
can cause its toxicity inside the human body. Its primary properties include anti-inflammatory actions, anti-aging properties, antibacterial
properties, anti-cancer properties, and obesity issues.
The Pharmacological Significance of Convolvulus Prostratus: Modern
Perspectives of An Ancient Herb
Authors: Gupta Jeetendra Kumar , Verma Jyoti , Khandelwal Girdhar , Singh Krishanveer , Singh Kuldeep
Published: November 2023

Convolvulus prostratus, also known as sankhapushpi, is a very adaptable plant frequently used as a nervine tonic, nootropic, and rejuvenator in
cases of insanity and epilepsy and has a broad spectrum of beneficial properties. Several medicinal qualities, including anxiety, neuroprotective,
antioxidant, analgesic, immunomodulatory, antibacterial, antidiabetic, and cardioprotective effects, have been related to this herb in ancient
literature. Numerous bioactive phytoconstituents, including kaempferol(flavonoid), ceryl alcohol, scopolamine(phenolics), and convolamine
(alkaloid), are associated with the therapeutic capabilities of this herb. The Whole herb or its juice is credited with alterative, antiphlogistic, and
nervine tonic action. Additionally, the involvement of C. prostratus extracts in neurodegenerative was thoroughly established. Although this
significant herb has comprehensive preclinical studies, thorough clinical research and mechanistic mode-of-action studies still need to be
conducted. With a detailed analysis of the research gaps, the current review aims to highlight the phytonutrient constituents, beneficial
characteristics, and therapeutic properties of C. prostratus. The creation of CNS phytopharmaceuticals, derived from C. prostratus, is hoped to
flourish due to the scientific upgrade on the ethnomedicinal characteristics of this herb.
Soft Switching Technique in a Modified SEPIC Converter with MPPT using Cuckoo Search Algorithm
Authors: Purushothaman Srinivasan , Senthamarai Heeravathi , Prasanna M. Jay , Pillai Sreedharsh R. , Dhanush M.
Published: November 2023

:

MPPT refers to the process of continuously tracking and adjusting the operating point
of a photovoltaic (PV) system to maximize the power output from the solar panels. The operating
point at which a PV system produces the most power under a specific set of environmental circumstances
is known as the maximum power point (MPP). The Maximum power point tracking
(MPPT) technique is used to overcome the challenges of PV arrays with variable irradiance levels,
which collects the greatest power from the PV array. Standalone PV systems, as well as gridconnected
systems, can benefit from a DC-DC converter with MPPT. This study compares the
standard perturbation and observation (P&O) technique with the soft-switching method used in
the SEPIC converter utilizing the cuckoo search (CS) algorithm using MATLAB/Simulink. Reviewing
the simulation results and assessing the SEPIC converter's performance.

Background:

SEPIC soft-switching converter, the soft-switching technique is applied to the
SEPIC converter topology. It typically uses additional components, such as inductor and capacitors,
to enable soft-switching operation. These additional components help to control the voltage
and current waveforms across the main switching devices, reducing switching losses.

Methods:

The proposed method uses a soft switching technique to reduce switching losses and to
improve efficiency. Soft switching is used in SEPIC (Single Ended Primary Inductor Converter)
converters, a type of DC-DC converter, to enhance their performance. The projected solution further
addresses the maximum power point tracking (MPPT) issue in PV systems using the Cuckoo
Search (CS) method.

Results:

Soft switching technique is implemented in SEPIC converters to reduce these switching
losses. In this system, Zero Voltage Switching (ZVS) involves turning on the switch when the
voltage across it is zero. This allows the current to flow through the switch without creating any
significant switching losses. CS algorithm can track the MPP quickly and accurately, it exhibits
less prone to oscillations, easily monitor the MPP under a variety of weather circumstances. However,
it exhibits negligible oscillation in a steady state, which results in significant power savings.

Conclusion:

The modified SEPIC converter with a soft-switching MPPT cuckoo algorithm is
used with a solar-powered system. A prototype comprising a solar panel, a SEPIC converter, a
driver, and a controller circuit was created. A soft-switching SEPIC converter with an MPPT
cuckoo algorithm for the PV system is implemented, as are the converter operation, converter
analysis, and theoretical analysis, and a controller circuit is analysed. The PV system, MPPT controller
with tracking algorithm, and PMSM load were used in the system simulation. A 60-watt
SEPIC converter prototype is built, and the outcomes are also tested experimentally.
Building Resilient Vaccine Supply Chain during COVID-19 Crisis
Authors: Lau Yui-yip , Tang Yuk Ming , Keung Alan Leung Wai
Published: November 2023

The COVID-19 pandemic occurred in the world in January 2020. Without
specific vaccines and antiviral treatments, the virus easily spreads across different parts
of the world. Accordance to the World Health Organization (WHO), COVID-19 has
widely spread to nearly all countries across six geographical regions (i.e., Western
Pacific, Africa, Eastern Mediterranean, South-East Asia, Europe, and Americas). In
doing so, different countries implemented various preventive measures like hand
washing, lockdowns, social distancing, and mask-wearing to minimize the transmission
of the virus. However, such preventive measures are short-term, ineffective, and may
not be sustainable. The introduction of common vaccination campaigns is viewed as a
vital effective way to against COVID-19. Over 60 vaccines for COVID-19 are either
previously endorsed or going through clinical experiments. As expected, there will be
an increasing need for people to accept vaccine injections. The vaccine is a highly
vulnerable, high-value, and rare product in the world. As such, resilient vaccine supply
chain management is urgently needed. Otherwise, the inferior quality of vaccines poses
global health risks and causes the problem of wasting useful medical supplies.
Nevertheless, some logistics firms encountered unfolded logistics challenges of the
COVID-19 vaccine due to a lack of professionals, capacity, data integrity, inventory
management, fluctuating demand, and geographic risk (e.g., vibration, location, shock,
and temperature. In particular, most logistics firms and health specialists encounter
severe challenges in managing the vaccine supply chain in remote areas or developing
countries. Although the vaccine is a global and hot issue for researchers, industrial
practitioners, local communities, and policymakers, there is scanty attention to
investigating the establishment of a resilience vaccine supply chain management in the
context of COVID-19. At present, only a few research groups have discussed the role
of blockchain in vaccine supply chain management, however, the information is not
enough to reveal the impact on how vaccine supply chain management of blockchain
can mitigate the COVID-19 crisis. Therefore, this chapter will mainly focus on the
overview of the influenza pandemic around the globe, the existing situation of the
COVID-19 pandemic in the world and Hong Kong, the current development of
vaccines during the COVID-19 pandemic, the adoption of blockchain in the vaccine
supply chain, and the vaccine logistics in COVID-19.
Law, Right to Freedom of Expression and a Fraternal Speech
Authors: Valdes Carlos Adolfo Sanabria
Published: November 2023

All rights, such as the right to freedom of expression, in some constitutions and Universal Declarations are mandatories to every government of any nations in order to protect the dignity of the human beings. There are many ways so as to protect that faculty. People and laws protect that juridical principle. Professors apply many teaching techniques so that they can promote the right to freedom of expression at schools, one of them is the discussion. It technique allows students express freely their opinions. All of them are valuable because every though gives aspects to enrich the right to freedom of expression. Everyone has principles in the classroom and speaks freely their thoughts because a juridical principle is the right to freedom of expression. It is worth promoting this human right at the universities because students can apply that faculty in the real life.
DATA REPLICATION IN DISTRIBUTED SYSTEMS USING OLYMPIAD OPTIMIZATION ALGORITHM
Authors: Arasteh Bahman , Bouyer Asgarali , Ghanbarzadeh Reza , Rouhi Alireza , Nazeri Mehrabani Mahsa , Tirkolaee Erfan Babaee
Published: November 2023

Achieving timely access to data objects is a major challenge in big distributed systems like the Internet of Things (IoT) platforms. Therefore, minimizing the data read and write operation time in distributed systems has elevated to a higher priority for system designers and mechanical engineers. Replication and the appropriate placement of the replicas on the most accessible data servers is a problem of NP-complete optimization. The key objectives of the current study are minimizing the data access time, reducing the quantity of replicas, and improving the data availability. The current paper employs the Olympiad Optimization Algorithm (OOA) as a novel population-based and discrete heuristic algorithm to solve the replica placement problem which is also applicable to other fields such as mechanical and computer engineering design problems. This discrete algorithm was inspired by the learning process of student groups who are preparing for the Olympiad exams. The proposed algorithm, which is divide-and-conquer-based with local and global search strategies, was used in solving the replica placement problem in a standard simulated distributed system. The 'European Union Database' (EUData) was employed to evaluate the proposed algorithm, which contains 28 nodes as servers and a network architecture in the format of a complete graph. It was revealed that the proposed technique reduces data access time by 39% with around six replicas, which is vastly superior to the earlier methods. Moreover, the standard deviation of the results of the algorithm's different executions is approximately 0.0062, which is lower than the other techniques' standard deviation within the same experiments.
Influencia de estilos de liderazgo transformacional, transaccional y laissez faire en la responsabilidad social corporativa, la imagen y reputación, así como en variables de resultado organizacional
Authors: Vidales Flores Laura Margarita , Mendoza Martínez Ignacio Alejandro , Xochitototl Nava Victor
Published: November 2023

Antecedentes: Desde sus orígenes las Organizaciones de la Sociedad Civil (OSC) en México fueron pensadas como instancias que deben crear valor público o utilidad social, que contribuya a promover el desarrollo. Por ello la importancia de conocer la influencia de su liderazgo en la gestión de sus proyectos. Método: con el propósito de determinar la influencia de los factores del liderazgo transformacional, transaccional y laissez faire en la imagen y reputación, así como en la responsabilidad social corporativa que pueden incidir en las variables de resultado (satisfacción, esfuerzo extra, efectividad), en la percepción de 303 trabajadores distribuidos entre directivos y subordinados de fundaciones con prácticas de responsabilidad social corporativa en México, a quienes se les suministraron los instrumentos “Adaptación del MLQ” y “Prácticas de Responsabilidad Social”. El estudio es expost facto, no experimental, transaccional. Resultados: los instrumentos mostraron niveles adecuados de confiabilidad y validez. Para contrastar la hipótesis general de investigación se empleó un modelo PLS-SEM con variables latentes, en el que se analizó de forma gráfica y estadística la influencia causal, la prueba se complementó procesando un re muestreo, observando que las hipótesis de trayectorias son beneficiadas en la prueba de significancia estadística a un intervalo del 95%. Conclusiones: el liderazgo transformacional (0.819) influyó en la imagen y reputación, explicando el 67.2% de su varianza, las que, a su vez (0.778) inciden en las variables de resultado manifestando el 60.5% de su varianza. Por otro lado, el liderazgo transformacional (0.741) y el liderazgo transaccional (-0.073) influyeron en la responsabilidad social corporativa, contribuyendo con el 49.3% de su varianza.
A Critical Analysis of Postbiotics: Exploring their Potential Impact on the Health and Food Industries
Authors: Babu A. Surendra , Guruprasath N. , Adeyeye S.A.O. , Sankarganesh P. , Kumar A. Ganesh , Sivapriya T.
Published: November 2023

Postbiotics are an emerging field in gut and gastroenterological research. Despite it being a vast field, limited scientific research has been conducted on this topic. Postbiotics are functional bioactive compounds generated in the cell wall matrix during fermentation that may be used to promote health. Postbiotics play a critical role in human immune development against communicable and noncommunicable diseases. This review focuses on the recent advances and future perspectives of postbiotics in health and food science. The review also discussed the criteria and different types of postbiotics and elucidated the significance of postbiotics. The paper further reviewed the role of postbiotics as preservatives, active ingredients in packaging systems, anti-biofilm agents, and decontaminant agents in food processing industries.
Impact of Russia-Ukraine War on International Trade and Finance
Authors: Gupta Aniket , S Anbu Saravanan , Raj Ashwal Emmanuel , Anshu  , Deka Argyam , V Aryan M , Kumari Asha
Published: November 2023

Abstract: Beyond its geopolitical roots, the conflict between Russia and Ukraine has had a significant effect on international trade and finance in both countries. This study explores the complex effects of the Russia-Ukraine conflict on national economies. This study examines the complex interactions between the factors influencing the internal trade and finance sectors using a thorough research technique that incorporates qualitative and quantitative assessments. This study investigates interruptions in supply networks, changes in trade patterns, and the difficulties experienced by firms in navigating geopolitical uncertainty in order to determine the impact on domestic commerce. The examination also explores the world of finance, investment environments, and currency stability. This research reveals complex insights into the dynamic economic landscape driven by geopolitical tensions through meticulous data collecting and strong analytical techniques. The results of this study show how the conflict between Russia and Ukraine has had a significant impact on domestic trade and finance. Businesses must adapt to shifting markets and geopolitical concerns while facing unprecedented obstacles. Financial institutions struggle with volatility, which calls for creative approaches to guarantee stability. Additionally, this research reveals policy ramifications, providing useful information for governments and companies looking to be resilient in the face of geopolitical unrest. In the end, this research offers useful information that is crucial for financial institutions, corporations, and governments in addition to advancing scholarly discourse. Stakeholders may successfully manage obstacles by comprehending the complex interactions between geopolitical conflicts and national economies. This will promote economic stability and sustainable growth in the face of difficulty.
Cosmic Humanism: A Vision of Humanism from Big History
Authors:   J.F. Oberlin University, Tokyo, Japan, Katayama Hirofumi
Published: November 2023

In this paper I pick up humanism, and try to show a vision of humanism based on Big History. Of course, the concept of humanism has its own long history, and it has various meanings. To examine them in detail is out of my scope. American Humanist Association defines humanism as: “Humanism is a progressive philosophy of life that, without theism or other supernatural beliefs, affirms our ability and responsibility to lead ethical lives of personal fulfillment that aspire to the greater good.” 1 Here, for the time being, I simply define it as an idea to admit human dignity and oppose those which oppress human beings, and discuss how Big History deals with this idea.
Precisiones, rectificaciones y noticias sobre la promoción de los Velasco en tierras de Burgos
Authors: BARRÓN GARCÍA Aurelio Á.
Published: November 2023

Precisamos algunos datos y aportamos noticias sobre la actividad patrimonial de los Velasco en Burgos y en La Rioja occidental. Identificamos a los enterrados en el panteón familiar de Medina de Pomar y precisamos las reformas que se hicieron en el monasterio de Santa Clara. Se revisa la acción de los Condestables en la capilla de la catedral de Burgos y se aportan noticias sobre el monasterio de Briviesca, que pasó de Juan Gil de Hontañón a Juan de Rasines en 1523. Comentamos los datos sobre la estancia de Simón de Colonia en Haro y sobre la construcción de un nuevo monasterio en Ajubarte.
El Alto Horno número 2 de la siderurgia de Puerto de Sagunto. Valoración patrimonial de un elemento industrial
Authors: BESÓ ROS Adrià
Published: November 2023

El Alto Horno número 2 de la siderurgia de Puerto de Sagunto es uno de los vestigios más representativos que se han mantenido en pie tras el cese de su actividad en 1984. Se iniciaba entonces un proceso de patrimonialización, en el que se inscribe la incoación de procedimiento para ser declarado Bien de Interés Cultural (BIC). El Plan Nacional de Patrimonio industrial establece unos criterios específicos para evaluar este tipo de bienes, que hemos aplicado en presente trabajo. La diversidad y relevancia de los valores que confluyen en este elemento nos llevan a determinar la procedencia dicho reconocimiento.
El San Sebastián del Museo de Arte Sacro de Teruel: una escultura inédita de Geörg Stieger (1657-1720)
Authors: CAMBRA SÁNCHEZ-GIL Álvaro
Published: November 2023

El presente trabajo pretende llevar a cabo el primer estudio histórico-artístico sobre una escultura inédita firmada por el artista italiano Geörg Stieger (1657-1720) y preservada en el Museo de Arte Sacro de Teruel. Se trata de una de las escasísimas obras autógrafas conservadas del autor, a cuya misteriosa personalidad artística hemos tratado de aproximarnos, así como la única conocida en nuestro país hasta la fecha. Además de realizar el estudio iconográfico de la pieza y de revisar los posibles modelos de los que pudo beber Stieger para confeccionar esta exquisita escultura, hemos podido precisar su llegada hasta tierras turolenses.
AZOFRA AGUSTÍN, Eduardo; GARCÍA-TALEGÓN, Jacinta y GUTIÉRREZ-HERNÁNDEZ, Alexandra M. (eds.), La piedra en el patrimonio monumental, Salamanca, Ediciones Universidad Salamanca, 2022
Authors: MARTÍNEZ MARÍN Cruz María
Published: November 2023

Esta novedad editorial forma parte de un proyecto de investigación sobre el uso de la piedra granítica en el Patrimonio Monumental del área sur-occidental de Castilla y León. Se enfoca en la utilización de la piedra granítica en la arquitectura de Salamanca, destacando su resistencia y su combinación con la arenisca de Villamayor en algunos casos.

La primera parte del libro aborda la conservación y restauración de la piedra. Una segunda parte está centrada en investigaciones relacionadas con el uso de materiales pétreos en el patrimonio monumental, como el empleo del granito en Ávila, el simbolismo del pórfido en un proyecto real, y el uso ornamental de la piedra en el hospital de las Cinco Llagas, entre otros temas. La tercera sección se enfoca en el estudio de las canteras históricas y el transporte de la piedra, incluyendo estudios sobre canteras graníticas en el área de Ávila, itinerarios geoturísticos, miliarios en la vía de la Plata, canteras en Bailén, calizas jaspeadas en Espejón, y el uso de bueyes en el transporte de piedra. Se revisan también las rutas y caminos de la Edad Moderna.
LEGAL PROTECTION OF OIL AND GAS MINING TO REALIZE SUSTAINABLE DEVELOPMENT
Authors: Santoso Ribuddi , Athoriq Muhammad A , Fairuz Numara Ardelia , Putri Ananda M Janur
Published: November 2023

Indonesia, as one of the countries with abundant natural resource potential, such as oil and gas, plays an essential role in the global energy landscape. As a Mining Authority (KP) stakeholder who collaborates with contractors through the oil and gas mining contract system, the government contributes to using oil and gas in various sectors, especially the industrial sector, as part of sustainable development efforts. Sustainable development with an environmental perspective is a conscious and planned effort that incorporates ecological aspects, including natural resources, into the development process to ensure the ability, well-being, and quality of life of current and future generations. The components of sustainable development include social, economic, and environmental aspects. The paradigm of sustainable economic development aims to achieve optimal production, improve the welfare of economic actors, and preserve the environment. In this paper, we will discuss the regulation of laws and technology for the management and utilization of oil and gas. Oil and gas resources in Indonesia require careful management and prioritization of the principles of sustainable development. The role of government through mining contracts and technological advances contributes to the optimization of oil and gas production. By integrating environmental considerations through technology into the development process and encouraging sustainable practices, Indonesia can ensure long-term resource availability, promote economic growth, and safeguard the well-being of current and future generations.
“Muslim Rimba”: Dialectic of Indigenous Belief Bukit Dua Belas National Park (TNBD) Jambi
Authors: Ramli Supian , Muspawi Mohammad , Rahman K.A. , Sobri Muhammad , Rafi’i Muhammad
Published: November 2023

Islam is the universal belief of mankind and as a dialogical religion is able to interact with various beliefs, various cultures and local traditions that develop in a multicultural society such as Indonesia. "Muslim Rimba" is associated as a religious subject who can reconcile the interpretation of Islamic teachings into local beliefs or the Religion of Rimba. An ethnographic approach was used in this study. Descriptions of observations, source interviews and participatory experiences are the strengths it. The findings of this study indicate after to be a Muslim Rimba view that the rituals and beliefs of rimba people are still carried out as a form of acculturation and respect for the teachings of indigenous peoples without leaving the commandments of the religious law they adhere to. The Muslim Rimba consistently participated in rituals such as Godong (Bebalai and Mandiko Budak); Sedang (Bedikir, Ngicap Rapah, Melantok Kedundung and Orang Beranok) and Kecik (Nyambatko Tuhan, Pepatiah Budak and Sanggokko).
Islam and Religion Plurality
Authors: Mahmud Amir
Published: November 2023

Islamic teachings value plurality or plurality as an unavoidable empirical reality. Each religion has different directions in carrying out worship or religious ceremonies. Understanding the activities of other religions besides those we profess within ourselves will foster an attitude of tolerance. Tolerance in religion does not mean we mix religious teachings, but respect each other and help create security and comfort for people of other religions in worship. Thus the plurality (diversity) of religion is a sunnatullāh that cannot be avoided in the life of society, nation, and state. In general, religion is the primary source of values in the culture. However, these values cannot change automatically manifest in the practice of human life. In other words, the values, ideas, and spirits introduced by religion, including Islam in it, are still passive. It must be distinguished between the wealth of treasures, thoughts, and religious principles contained in the holy book, or religious book, with the ability of its adherents or institutions to interact with the role of civilization. In that realm, conflicts of interest and assertion of identity will emerge on a different scale
A study on the implementation of Koha cataloguing module in Malaysian academic libraries
Authors: (Corresponding Author) S.A. Sharifah Nur Amirah , Sa’adah M.N. Nor , Nurul Aini N.Y.
Published: November 2023

The study explores the experiences of the Malaysian academic libraries’ cataloguers in their use of the cataloguing module of Koha Open Source Software (OSS). The purpose of this study is to shed light on issues concerning Koha cataloguing module and the local practices in policy and procedure while utilising the module. An exploratory sequential research design was adopted for the study involving an online focus group interview and a questionnaire survey as the data collection techniques. Twenty-two academic libraries from public and private universities in Malaysia were purposively sampled. A total of six academic libraries participated in the focus group, whereas 41 participants took part in the survey. The study highlighted academic libraries in Malaysia embrace Koha for two main reasons - popularity as and OSS and budget constraints for a proprietary library system. The findings of the study revealed that missing records is a significant issue that cataloguers will have to deal with and there is a lack of certain features available in the Koha cataloging module, such as the label creator and search feature. Apart from that, using Koha for cataloguing does not affect the cataloguing practices in terms of policy, but it does affect the cataloguing procedure. Satisfaction level with Koha cataloguing module is high. Other academic libraries in Malaysia that have not yet made a move to Koha or are in the midst of doing so would benefit from this study.
Metadata matters: evaluating the quality of Electronic Theses and Dissertations (ETDs) descriptions in Malaysian institutional repositories
Authors: Osman Raudhah , (Corresponding Author) Yanti Idaya A.M.K. , A. Abrizah
Published: November 2023

This study investigates the quality of metadata records in institutional repositories for Electronic Theses and Dissertations (ETDs) in three Malaysian research universities. The study employs metrics derived from Bruce and Hillmann (2004) to evaluate the completeness, accuracy, and consistency of 1138 metadata records from the three institutional repositories, and utilizes quantitative content analysis to identify variants of Dublin Core metadata elements used to describe ETDs. The study uncovers a range of issues with metadata completeness, accuracy, and consistency, emphasizing the need for standardized systems to ensure quality metadata. By highlighting the importance of quality metadata for ETD collections, the study provides valuable insights for academic libraries in designing and describing ETD collections. Overall, this study sheds light on the current metadata practices and elements used in ETD collections, and underscores the significance of effective metadata management for the dissemination and discoverability of scholarly works.
Exploring authors engagement in journals with questionable practices: a case study of OMICS
Authors: (Corresponding Author) Cherifa Boukacem-Zeghmouri , Pergola Lucas , Castaneda Hugo
Published: November 2023

The paper aims to understand the context and drivers of researchers' decision to submit a manuscript to a journal with questionable practices. Using OMICS as a case study and asking authors for their views, the paper presents their profile, motivations and publishing experiences. The methodology is based on a questionnaire sent by e-mail to all authors of articles in journals published by OMICS (+2200). The authors were asked about (a) the factors that influenced their decision to submit their article; (b) their publishing experience with OMICS; (c) their level of satisfaction; and (d) whether or not they would repeat the experience. A total of 86 responses were collected and 18 e-mails were received. The analysis made it possible to add details to the profiles of authors already identified in the literature, but also allowed new and more nuanced profiles. This research extends our knowledge on the phenomenon of predatory publishing from the authors' feedback and provides a better understanding of the socio-economic, psychosocial and geo-political conditions that drive researchers' decisions to submit their work to a possible, potential, or probable predatory journal. At the same time, it reveals some of the strategies used by OMICS to persuade authors to submit their papers. The findings will help to inform institutional policies that seek to put in place efficient measures to combat predatory publishing.
Continuous improvement of FEV 1 in severe eosinophilic asthmatics on anti-interleukin-5 therapy.
Authors: Muylem Alain Van , Michils Alain , Makhoul Jean-Pierre , Blekic Nathan , Haccuria Amaryllis , Perez-Bogerd Silvia , Malinovschi Andrei
Published: November 2023

Background: Severe asthma is associated with an accelerated
lung function decline which is likely attenuated by the addition of
anti-nnterleukin-5 (IL-5) therapy in patients with severe eosinophilic
asthma. Objective: To study the long-term impact of add-on
therapy with anti-IL-5 on FEV in severe eosinophilic
asthma patients. Methods: In this post-hoc analysis, we
compared, through a linear mixed model, the evolution of
pre-bronchodilation FEV expressed in %pred in a
cohort of 50 patients with severe eosinophilic asthma treated with
anti-IL-5 (1576 visits) before (median follow-up: 9.2 years) and after
(median follow-up: 2.1 years (up to 6.8 years) anti-IL-5 therapy start.
Results: FEV decline was observed before
anti-IL5 start (-0.6 %pred.year ,
p<0.001). FEV improved significantly after
anti-IL-5 start (+1.3 %pred.year
p<0.001; difference pre-post: p<0.001). A sustained
improvement was observed in 31 patients deemed responders (+3.1
%pred.year , p<0.001; difference
pre-post: p<0.001) vs a continuous decline in 19 patients
considered as non-responders (-0.40 %pred.year ,
p=0.087; difference pre-post: p=0.097). Non-responders exhibited a
higher prevalence of nasal polyposis, better asthma control and a trend
towards higher exhaled nitric oxide values. Conclusion: This
post-hoc analysis shows that add-on therapy with anti-IL-5 not only
stems the accelerated decline in lung function but also makes it
reversible in many severe eosinophilic asthma patients, leading to an
estimated improvement of 11% FEV %pred after 3 years
of treatment. Persistent improvement in lung function is therefore
feasible in severe asthmatics and could be chosen as a lung function
criterion to define remission of asthma under treatment.
Distributed Adaptive Learning Consensus Tracking Control for a Class of Nonlinear 2-D Multi agent Systems With Nonrepetitive Conditions
Authors: Wei Yun-Shan , Xu Qing-Yuan , Mai Qing-Quan , Guo Mian , Wan Kai
Published: November 2023

This study tackles the output consensus problem for a class of nonlinear
two-dimensional (2-D) multi agent systems that do complex tasks
repetitively in a finite domain via iterative learning control (ILC).
The aim is to design a distributed adaptive learning consensus tracking
control strategy that enables all 2-D multi agents to achieve the task
of consensus tracking control under nonrepetitive conditions, even if
only a part of the agents can detect the reference surface. An adaptive
parameter, which adjusted by the tracking errors of the agent itself and
the neighbor agents in the last iteration, is designed to approximate
the unknown varying parameter of the nonlinear 2-D agent. Then, based on
the approximated parameter and the iteration-varying reference surfaces,
the distributed adaptive learning consensus tracking control strategy is
obtained and the convergence of the output consensus tracking control is
proved. In the end, simulations are presented to verify the
effectiveness of the investigated distributed adaptive learning
consensus tracking control for 2-D multi agent system with random
variations on initial boundary and reference surface.
Elucidating Linear Programs by Neural Encodings
Authors: Busch Florian Peter , Zečević Matej , Kersting Kristian , Dhami Devendra Singh
Published: November 2023

Linear Programs (LPs) are one of the major building blocks of AI and
have championed recent strides in differentiable optimizers for learning
systems. While there exist efficient solvers for even high-dimensional
LPs, explaining their solutions has not received much attention yet, as
explainable artificial intelligence (XAI) has mostly focused on deep
learning models. LPs are mostly considered whitebox and thus assumed
simple to explain but we argue that they are not easy to understand in
terms of relationships between inputs and outputs. To mitigate this
rather non-explainability of LPs we show how to adapt attribution
methods by encoding LPs in a neural fashion. The encoding functions
consider aspects such as feasibility of the decision space, the cost
attached to each input and the distance to special points of interest.
Using a variety of LPs, including a very large-scale LP with 10k
dimensions, we demonstrate the usefulness of explanation methods using
our neural LP encodings, though, the attribution methods Saliency and
LIME are indistinguishable for low perturbation levels. In essence, we
demonstrate that LPs can and should be explained which can be achieved
by representing an LP as a neural network.
Anatomical and visual outcomes of pars plana vitrectomy combined with inverted internal limiting membrane flap technique and perfluoropropane tamponade in high myopia macular holes with or without foveoschisis.
Authors: Chen Huan , Wang Chenxi , Yu Jiafeng , Chen Yiqi , Mao Jianbo , Zhang Shian , Shen Lijun
Published: November 2023

Purpose: To evaluate the efficacy and safety of vitrectomy combined with
inverted internal limiting membrane (ILM) flap technique and
perfluoropropane tamponade (C3F8) for the treatment of high myopia
macular holes (HMMH) with or without macular foveoschisis (MF). Methods:
This is a retrospective, observational case series study. Sixty-seven
eyes of 67 patients who underwent vitrectomy with inverted ILM flap and
C3F8 tamponade were enrolled. The main outcome measures were
best-corrected visual acuity (BCVA), the closure rate of HMMH and the
integrity of ellipsoid zone (EZ) and external limiting membrane (ELM) at
the final follow-up visit. Results：There was no significant difference
in the BCVA and the closure rate of HMMH at the final follow-up between
the two groups. However, the recovery of ELM and EZ was significantly
higher in the no MF group than in the MF group at the final follow-up.
Specifically, ELM and EZ were restored in 17 eyes (50.0%) and 10 eyes
(29.4%) of the no MF group, respectively, while only 4 eyes (12.1%)
and 2 eyes (6.1%) of the MF group achieved ELM and EZ restoration,
respectively. Conclusion: Vitrectomy with inverted ILM flap technique
and C3F8 tamponade is an effective and safe method to achieve a high
anatomical success rate of HMMH closure and improve visual function.
However, the presence of foveoschisis may impair the structural recovery
of the outer retinal layer.
New methods for enhance the transdermal drug delivery effect of macromolecular drugs： A review
Authors: li heng , shi yanbin , Ding Xinbing , Zhen Chengdong , Lin Guimei , Wang Fei , Tang Bingtao , Li Xuelin
Published: November 2023

Transdermal drug delivery has made great progress in transdermal
delivery of macromolecules in recent years, offering a non-invasive and
convenient approach for drug administration. By bypassing first-pass
metabolism and reducing the risk of drug toxicity, transdermal drug
delivery holds great promise in the field of medicine. However, the
permeability of the skin barrier limits the range of drugs that can be
effectively delivered. To overcome this challenge, researchers have been
exploring the integration of multiple technologies to enhance
transdermal drug delivery. This review provides an overview of different
transdermal drug delivery methods, including microneedles and
microneedle combination technologies needle-free injectors, and other
methods such as chemical enhancers, temporary pressure, and
transferosomes. The advantages, limitations, and considerations for each
method are discussed, taking into account factors such as drug delivery
efficiency, patient compliance, skin damage, and post treatment skin
recovery. Furthermore, the review highlights the potential of combining
these technologies to improve drug permeation across the skin barrier.
Integration of physical enhancement techniques such as microneedles and
sonophoresis, chemical enhancers, and novel drug delivery systems like
nanoparticles and hydrogels have shown promising results in enhancing
drug delivery efficiency, increasing drug stability, and achieving
controlled release. Additionally, the combination of technologies allows
for the optimization of drug delivery parameters, enabling personalized
and targeted therapy.
Chronic ethanol ingestion on the uterine horn of Calomys callosus
Authors: Martinez F. , Martinez Marcelo , Garbuio D.
Published: November 2023

The present work was carried out to evaluate the possible effects of
chronic alcohol intake on the histology and ultrastructure of the
endometrial lining epithelium of the uterine horn of Calomys callosus.
20 adult female rodents, Calomys callosus, three months old, were used.
These animals were divided equally into 2 experimental groups called
control and alcoholic. The control group received a solid diet (mouse
food) and tap water “ad libitum”. The alcoholic group received the
same solid diet and ethanol was diluted to 20% in water. At the end of
120 days of treatment with 20% alcohol, all animals were anesthetized
with ethyl ether and sacrificed. Daily observations of the animals’
behavior, carried out throughout the treatment period, made it possible
to verify a certain lethargy of the animals in the alcoholic group,
concerning the animals in the control group, regarding responses to
physical and sound stimuli. Macroscopically, no difference was observed
in the uterus between the groups analyzed. In light microscopy, the
animals in the alcoholic group showed the same histological
characteristics as the control group, however, a marked atrophy of the
epithelial tissue covering the endometrium could be observed. This
atrophy is confirmed by the results of transmission electron microscopy,
where important changes were also observed in alcoholic animals: a large
increase in lipid droplets, dispersed throughout the cytoplasm,
digestive vacuoles, and an increase in the cisterns of the granular
endoplasmic reticulum. The presence of invasive immune cells in the
epithelial tissue was also observed. Scanning electron microscopy
analyses showed the presence of lipid droplets in the endometrial lumen.
Ethanol ingestion caused epithelial lesions in the uterine horn, causing
apoptosis, and interfering with the secretory mechanism.
The seed germination properties of two hyperaccumulator plant species with the potential for Ni agromining
Authors: Kyrkas Dimitrios , Mantzos Nikolaos , Patakioutas George , Echevarria Guillaume , Filis Evaggelos , Dimitrakopoulos Panayiotis , Konstantinou Maria
Published: November 2023

The aim of this study is to investigate the effect of different nickel
concentrations and light in combination with storage conditions and storage
time on the seed germination ability of two serpentine-endemic nickel
hyperaccumulating species (Bornmuellera emarginata and B. tymphaea). The
seeds of both species were collected from natural populations in the Pindus
Mountain range, Greece in early July and stored in a refrigerator (4?C) and
in laboratory conditions (22?C). The seeds were exposed to a range of nickel
concentrations typical of non-ultramafic-ultramafic gradient in two light
environments (12 h photoperiod and continuous darkness). The nickel
concentration only had a significant effect on B. emarginata, decreasing its
seed germination rate with increasing Ni concentrations. The storage
temperature significantly affected the germination percentage of both
species and it was higher at 4?C compared to 22?C. A higher germination rate
(> 60%) was observed for 5-8-month-old seeds, but both species generally
showed significantly higher germination rates in the tests conducted seven
months after seed ripening in the field. A higher germination rate was
observed in a 12-hour photoperiod than in continuous darkness only for B.
tymphaea. This study provides guidelines on the germination capacity of two
obligate nickel hyperaccumulators with a potential for use in agromining
systems.
Expression of heavy metal ATPases (HMA1 and HMA3) in Brassica nigra and B. juncea grown at different Cu levels
Authors: Meraklı Nuriye , Memon Abdulrezzak
Published: November 2023

Metal pollution is a major environmental problem which affects agriculture
and human health. Turkey has significant Cu mining areas in Diyarbak?r and
its surrounding areas (Southeast Anatolia). Several crop plants cultivated
in these areas are irrigated with water from the Tigris, and most
agricultural lands are contaminated with Cu. Brassica nigra and B. juncea
are well-known metal accumulator plant species which can hyperaccumulate
metals, including copper, in their shoots. The purpose of this study is to
evaluate their potential for the phytoremediation of Cu from these
contaminated areas as an environmentally friendly and cost-effective means
of reducing Cu-contamination. In this research, B. nigra and B. juncea
plants were grown in soil at different Cu concentrations (0 to 1000 ?M) and
showed no toxicity symptoms while accumulating a significant amount of metal
in their leaves. In the leaves of both species, the Cu content increased
significantly with the increase in the Cu level in the media. HMA1 (Heavy
Metal ATPase 1) in the leaves of both plant species gradually increased with
increased Cu levels until 50 ?M, then its expression slowly decreased with
the further increase in Cu levels. The expression of HMA3 also increased
with an increase in Cu in the leaves of both plant species. However, its
expression pattern differed from that of HMA1. Our data showed that an
increase in Cu levels in the leaves triggers the expression of both genes,
suggesting that they play an active role in Cu detoxification. We propose
that these plant species could be used for the decontamination of Cu from
polluted soils. These data also indicate that Cu accumulation and tolerance
in both plant species is probably a multi-genetic response, possibly
involving several other transporter genes in the stress signal pathway.
Hence, we also explored the expression of the other metal transporters, such
as other HMAs (HMAs 5-8), Nramps (e.g., Nramp3), COPT proteins, and some Cu
chaperons in these plant species.