bluuebunny/crossref_metadata_2025 huggingface dataset:
Eco-Friendly Sanitization of Indoor Environments: Effectiveness of Thyme Essential Oil in Controlling Bioaerosol Levels and Disinfecting Surfaces
Authors: Sateriale Daniela , Forgione Giuseppina , De Cristofaro Giuseppa Anna , Continisio Leonardo , Pagliuca Chiara , Colicchio Roberta , Salvatore Paola , Paolucci Marina , Pagliarulo Caterina
Published: April 2024

Bioaerosols and pathogens in indoor workplaces and residential environments are the primary culprits of several infections. Techniques for sanitizing air and surfaces typically involve the use of UV rays or chemical sanitizers, which may release chemical residues harmful to human health. Essential oils, natural substances derived from plants, which exhibit broad antimicrobial properties, could be a viable alternative for air and surface sanitation. The objective of this study has been to investigate the efficacy of thyme essential oil (TEO) in environmental sanitation processes. In Vitro assays through agar well diffusion, disk volatilization and tube dilution methods revealed significant antimicrobial activity of TEO 100% against foodborne and environmental isolates, with both bacteriostatic/fungistatic and bactericidal/fungicidal effects. Therefore, aqueous solutions of TEO 2.5% and 5% were formulated for air sanitation through nebulization and surface disinfection via direct contact. Bioaerosol samples and surface swabs were analyzed before and after sanitation, demonstrating the efficacy of aqueous solutions of TEO in reducing mesophilic and psychrophilic bacteria and environmental fungi levels in both air and on surfaces. The obtained results prove the antimicrobial potential of aqueous solutions of TEO in improving indoor air quality and surface cleanliness, suggesting thyme essential oil as an effective and safe natural sanitizer with minimal environmental impact compared to dangerous chemical disinfectants.
Neuropsychopharmacological Induction of (Lucid) Dreams: A Narrative Review
Authors: Oldoni Abel A. , Bacchi André D. , Mendes Fúlvio R. , Tiba Paula A. , Mota-Rolim Sérgio
Published: April 2024

Lucid dreaming (LD) is a physiological state of consciousness that occurs when dreamers become aware that they are dreaming, and may also control the oneiric content. In the general population, LD is spontaneously rare; thus, there is great interest in its induction. Here, we aim to review the literature on neuropsychopharmacological induction of LD. First, we describe the circadian and homeostatic processes of sleep regulation and the mechanisms that control REM sleep with a focus on neurotransmission systems. We then discuss the neurophysiology and phenomenology of LD to understand the main cortical oscillations and brain areas involved in the emergence of lucidity during REM sleep. Finally, we review possible exogenous substances—including natural plants and artificial drugs—that increase metacognition, REM sleep, and/or dream recall, thus with the potential to induce LD. We found that the main candidates are substances that increase cholinergic and/or dopaminergic transmission, such as galantamine. However, the main limitation of this technique is the complexity of these neurotransmitter systems, which challenges interpreting results in a simple way. We conclude that, despite these promising substances, more research is necessary to find a reliable way to pharmacologically induce LD.
Differential Risk: Gender and Racial Differences in the Relationship between Trauma, Discrimination, and Schizotypy
Authors: Monette Mahogany A. , Russell Madisen T. , Abel Danielle B. , Lewis Jarrett T. , Mickens Jessica L. , Myers Evan J. , Hricovec Megan M. , Cicero David C. , Wolny J. , Hetrick William P. , Masucci Michael D. , Cohen Alex S. , Burgin Christopher J. , Kwapil Thomas R. , Minor Kyle S.
Published: April 2024

Traumatic experiences are associated with increased experiences of positive schizotypy. This may be especially important for People of Color, who experience higher rates of trauma and racial discrimination. No study to date has examined how racial disparities in traumatic experiences may impact schizotypy. Furthermore, of the studies that have examined the relationship between trauma and schizotypy, none have examined racial discrimination as a potential moderator. The present study examined if racial discrimination moderates the relationship between trauma and multidimensional (positive, negative, and disorganized) schizotypy. In a sample of 770 college students, we conducted chi-squared analyses, analyses of variance, and stepwise regressions. We found that Black students experienced significantly higher racial discrimination and trauma than Latinx and Asian students. Furthermore, Black and Latinx students experienced significantly more multidimensional schizotypy items than Asian students. Trauma and racial discrimination explained 8 to 23% of the variance in each dimension of schizotypy. Racial discrimination did not moderate the relationships between trauma and multidimensional schizotypy. Our findings suggest that we need to examine risk factors that may prevent recovery from psychotic disorders. Additionally, disorganized schizotypy showed the most robust associations and may be a critical site of intervention.
Differences in Cold and Hot Decision-Making between Gambling and Other Addictions
Authors: Meca Sara , Molins Francisco , Puigcerver Maragda , Serrano Miguel Ángel
Published: April 2024

Behavioral and biological addictions can impair decision-making processes, mainly by means of a dysfunction in brain regions associated with reward and frontal areas that may lead to disadvantageous choices. Understanding these differences helps establish appropriate terminology and enhances our ability to recognize, prevent, and treat these disorders effectively. Thus, while behavioral and biological addictions share some common elements, their underlying mechanisms and impact on decision-making vary significantly. Moreover, decision-making can be measured through questionnaires (stable or “cold” measures) or dynamic tasks (hot decisions) such as the Iowa Gambling Task (IGT), which can reflect different dimensions of this process. The aim of this study was to compare decision-making from different perspectives—stable and dynamic measures—in patients with gambling addiction (GA) (n = 42) and patients with biological addictions (BA) (n = 43). Decision-making was assessed using GDMS (Decisional Styles) and the LCT (Loss Aversion), as cold decision-making measures, as well as a hot or situational task called the IGT (Iowa Gambling Task). The results revealed that GA patients exhibited lower rational style scores compared to BA patients. Additionally, GA patients showed greater loss aversion according to the LCT questionnaire. On the other hand, when analyzing the IGT results, no differences were observed between groups in the overall IG index, learning curves, or the loss aversion parameter. However, GA patients showed higher sensitivity to feedback and less consistency in their decisions. These findings highlight the differences between different types of addictions and highlight the importance of considering the type of measure used to evaluate decision-making.
Flourishing in Education: Psychometric Properties of the Flourishing Scale in a Sample of Romanian Teachers
Authors: Balgiu Beatrice Adriana , Simionescu-Panait Andrei
Published: April 2024

The Flourishing Scale (FS) is one of the most well-known tools for assessing psychological flourishing. However, its psychometric properties have been little analyzed in the case of teachers. This study aimed to examine the validity of the scale in the case of a sample of Romanian teachers and to analyze the latter’s level of flourishing. In this regard, 323 Romanian teachers from the pre-university education system were recruited. Confirmatory factor analysis (CFA) was used to assess the construct validity of the scale, and Cronbach’s α and McDonald’s ω indices were used to assess internal consistency. The convergent validity was assessed by associating the FS with other instruments related to well-being: the Mental Health Continuum-Short Form and the Scale of Positive and Negative Experience. Network analysis was performed to examine the items that are particularly influential in the scale. As a result of the CFA, the one-factor structure of the scale was certified (χ2/df = 1.39; CFI = 0.99; RMSEA = 0.035). The internal consistency is excellent (both α and ω = 0.89). The FS correlates with both of the scales which operationalize components of well-being. The teachers’ flourishing level is above average. The network approach showed that the items related to self-acceptance, optimism, and respect had the highest indicators of centrality, and the item related to supportive social relationships was the least informative in the network. For the male subsample, flourishing means optimism about the future and respect for others, and for the female respondents, it is related to self-acceptance and respect. The results provide support for using the scale in assessing flourishing among teachers.
Evidence-Based Reconstruction of Memories of a Disdainful Hookup: Identifying Risk Factors and Preventing Further Victimization
Authors: Puigvert Lidia , Flecha Ramon , Racionero-Plaza Sandra
Published: April 2024

Autobiographical memories of close relationships have been shown to have strong influence in health and life. Yet, there is no research published about longitudinal memory reconstruction of violent sporadic relationships while reading and discussing scientific evidence on gender violence victimization. This article presents a novel case of the reconstruction throughout time of the memory of a disdainful hookup experienced by a young woman. The victim’s diary and an interview were the sources of data collection. The analytical categories were developed in dialogue with the participant. The results indicate that, as the subject learned scientific evidence on gender violence in sporadic relationships, she progressively recalled details of the episode that she had self-censored before, became aware of the very violent nature of the hookup, rejected the relationship, and freed her desire for satisfactory romantic relationships.
Maternal Involvement in Education, Bicultural Acceptance, and School Adjustment: An Autoregressive Cross-Lagged Modeling Study among Adolescents from Multicultural Families
Authors: Lim Yangmi
Published: April 2024

This study examined the associations between maternal involvement in education and bicultural acceptance and school adjustment during the first year of middle school among adolescents from Korean multicultural families as well as the reciprocal relationships between bicultural acceptance and school adjustment during the three years of middle school. The present study used three-wave longitudinal data of 1185 dyads of adolescents (50.8% girls; mean age = 12.96 ± 0.35 years at the first wave) and their immigrant mothers (mean age = 43.54 ± 5.19 years at the first wave), who participated in the Multicultural Adolescents Panel Study. An autoregressive cross-lagged modeling analysis revealed that maternal involvement in education was significantly and positively associated with adolescents’ bicultural acceptance and school adjustment in the first year of middle school. Individual levels of bicultural acceptance and school adjustment among adolescents remained moderately stable over the three years. Whereas the positive effects of school adjustment on bicultural acceptance were significant over time, the effects of bicultural acceptance on school adjustment were not. Finally, this study highlights the roles of intervention programs (e.g., parent and multicultural education) in facilitating maternal involvement in education and school adjustment as well as in increasing bicultural acceptance among minority youths.
Morphological and Position Factors of Vertical Surface Light Source Affecting Discomfort Glare Perception
Authors: Kong Guangyan , Wang Lixiong , Chen Peng , Wang Shuo , Ma Fengrui
Published: April 2024

Distinguished from conventional lighting, the LED vertical surface light source (VSLS) is directly exposed to human view, and the effects of which form it takes on visual perception are non-negligible. In the current discomfort glare evaluation system, the solid angle and the position index, which represent the relative relation between the glaring light source and human visual field, are not completely applicable for large-area VSLS, and hence are awaiting supplementation and modification. In this study, a physical experimental setup was established to conduct an evaluation experiment on discomfort glare, employing an LED display and white translucent frosted film to simulate vertical surface light sources (VSLS). The experiments were arranged with 21 VSLS shapes (comprising 3 areas and 7 length-to-width ratios) and 11 mounting positions. Subjective ratings and four eye-movement data parameters—namely, the change rate of pupil diameter (CRPD), mean saccadic amplitude (SA), blinking frequency (BF), and saccadic speed (SS)—were collected from 24 participants under each working condition using the Boyce Evaluation Scale and eye tracking techniques. The main results of this study are the following: (a) CRPD is the most appropriate eye-movement index for characterizing VSLS glare perception; (b) The area of the VSLS is the primary shape element influencing discomfort glare. Furthermore, with the same surface area, the lateral view angle (LaVA) and the longitudinal view angle (LoVA) perceived by the human eye also impact glare perception; (c) A functional equation between the VSLS area, LaVA, and LoVA to the borderline luminance between comfort and discomfort (BCD luminance) is fitted; (d) Based on the eccentric angle and the azimuthal angle, a modified position index P’ is proposed to represent the relative position of the VSLS in the visual field, and the ratio function of BCD luminance of the VSLS at non-central positions and the central position is fitted.
Replacing Fly Ash or Silica Fume with Tuff Powder for Concrete Engineering in Plateau Areas: Hydration Mechanism and Feasibility Study
Authors: Li Tianqi , Li Bixiong , Li Lianghui , Wang Zhiwen , Zhang Zhibo , Nong Qingshun
Published: April 2024

Abundant tuff mineral resources offer a promising solution to the shortage of fly ash (FA) and silica fume (SF) resources as emerging supplementary cementitious materials. However, a lack of clarity on its hydration mechanism has hindered its practical engineering application. In this study, high SiO2-content tuff powder (TP) was examined to assess the mechanical and workability performance of mortar specimens with varying particle sizes of the TP as complete replacements for FA or SF. Microscopic analysis techniques, including X-ray diffraction (XRD), differential thermal analysis (DTG), and energy-dispersive X-ray spectroscopy (EDS), were employed to elucidate the hydration mechanism of the TP and its feasibility as a substitute for SF or FA. Results indicated that TP primarily functions as nuclei and filler, promoting cement hydration, with smaller particle sizes amplifying the hydration ability and increasing Ca(OH)2 and C-S-H gel content. The specimens with TP (median particle size 7.58 μm) demonstrated 9.2% and 29.9% higher flexural and compressive strengths at 28 days, respectively, compared to the FA specimens of equal mass. However, fluidity decreased by 23.1% accordingly. Due to TP’s smaller specific surface area compared to SF, the TP specimens exhibited higher fluidity but with decreased strength relative to the SF specimens. Overall, TP shows potential as a replacement for FA with additional measures to ensure workability.
Development of Worth Estimation and Key Target Selection Methods for Effective VE
Authors: Jeong Yeon-Goo , Jeong Hye-Min , Kim Byung-Soo
Published: April 2024

VE is a powerful technique for analyzing a design with a focus on functionality, reducing costs, and increasing value. However, in order to proceed with the design of VE, the theoretical basis for the VE target selection process, which must be preceded in the preparation stage, is lacking, and as a result, it is difficult to verify the most effective target selection. Thus, a theoretical basis is needed. In this study, we intend to quantify the “Worth” value of the “Cost to Worth” technique and present an objective model of the target selection method using the derived value index (VI). For this purpose, cost worth (Worth C) was calculated based on the performance data of 1008 cases for 15 building types provided by the Domestic Public Procurement Service and the share of 83 detailed processes in seven fields. Then, a survey was conducted targeting the ordering companies, and the final worth (Worth F) was calculated by multiplying the derived customer value (Worth V) weight for each detailed work type. We calculated the value index (VI) by comparing “Cost” and “Worth F” for each detailed construction type of the VE project and developed a model to select construction types that exceed the VI standard value derived using the standard error of the population. Both cost experts and non-cost experts can use the developed model to specify the VE target selection criteria in order to easily select the key target, objectively sort the values that serve as the basis for calculating the value index, and make it possible to more easily select the VE target selection criteria based on theoretical evidence. Also, the model can be used to obtain effective detailed design VE results.
Examining the Challenges for Circular Economy Implementation in Construction and Demolition Waste Management: A Comprehensive Review Using Systematic Methods
Authors: Ferriz-Papi Juan Antonio , Lee Angela , Alhawamdeh Mahmoud
Published: April 2024

The construction industry accounts for approximately one-third of the total waste generation globally. With the United Nations projecting a population increase of 2 billion within the next three decades, there is a heightened demand for building stock, generating unprecedented volumes of construction and demolition waste (CDW). To combat this, circular economy strategies are purported to help alleviate the prevailing situation. But a number of challenges are jeopardizing their implementation in the construction industry and preventing from achieving the UN Sustainable Development Goals, net zero carbon and zero avoidable waste targets. This paper systematically analyzes 54 research articles, published in the past decade within major peer-reviewed English-language scholarly publications in the form of a systematic research review. In doing so, it aims to identify and classify the challenges that prevent improved CDW management by assimilating previous research results in support of a circular economy. The classification and analysis using a PESTLE model offers insights into gaps and differences between categories, as well as regions and countries. This initial step could contribute to a better understanding of these barriers, along with associated solutions, which could result in a significant reduction on the impact of construction activities, therefore facilitating the development of an effective circular economy in the sector.
Adaptive Vibration Monitoring of Railway Track Structures Using the UWFBG by the Identification of Train-Load Patterns
Authors: Chen Jiahui , Li Qiuyi , Zhang Shijie , Lin Chao , Wei Shiyin
Published: April 2024

Due to the capability of multiplexing thousands of sensors on a single optical cable, ultra-weak fiber Bragg grating (UWFBG) vibration sensing technology has been utilized in monitoring the vibration response of large-scale infrastructures, particularly urban railway tracks, and the volume of the collected monitoring data can be huge with the great number of sensors. Even though the train-induced vibration responses of urban railway tracks constitute the most informative and crucial component, they comprised less than 7% of the total operational period. This is mainly attributed to the temporal sparsity of commuting trains. Consequently, the majority of the stored data consisted of low-informative environmental noise and interference excitation data, leading to an inefficient structural health monitoring (SHM) system. To address this issue, this paper introduced an adaptive monitoring strategy for railway track structures, which is capable of identifying train-load patterns by leveraging deep learning techniques. Inspired by image semantic segmentation, a U-net model with one-dimensional convolution layers (U-net-1D) was developed for the pointwise classification of vibration monitoring data. The proposed model was trained and validated using a dataset obtained from an actual urban railway track in China. Results indicated that the proposed method outperforms the traditional dual-threshold method, achieving an Intersection over Union (IoU) of 94.27% on the segmentation task of the test dataset.
The Current Achievements of Multi-Gene Panel Tests in Clinical Settings for Patients with Non-Small-Cell Lung Cancer
Authors: Sakaguchi Tadashi , Iketani Akemi , Esumi Seiya , Esumi Maki , Suzuki Yuta , Ito Kentaro , Fujiwara Kentaro , Nishii Yoichi , Katsuta Koji , Yasui Hiroki , Taguchi Osamu , Hataji Osamu
Published: April 2024

Some multi-gene panel tests have been implemented in clinical settings to guide targeted therapy in non-small-cell lung cancer (NSCLC) in Japan. The current performance of multi-gene panel tests under the condition that the Oncomine Dx Target Test (ODxTT) and Amoy Dx® Pan Lung Cancer PCR panel (AmoyDx-multi) are available remains relatively unknown. We retrospectively reviewed consecutive patients with NSCLC, whose FFPE samples were considered for genetic testing. We assessed the submission rates, the success rates, and the driver oncogene detection rates of multi-gene panel tests. A total of 225 patients were histologically newly diagnosed with NSCLC or diagnosed with a recurrence of NSCLC without a previous multi-gene panel test at our institution. Among the 225 patients, the FFPE samples of 212 patients (94.2%) were submitted for multi-gene panel testing, including 191 samples (84.9%) for the ODxTT and 21 samples (9.3%) for the AmoyDx-multi. Among the 212 samples submitted to multi-gene panel tests, the success rate was 99.5% (211/212). The detection rate of driver oncogene alterations for all histologies was 52.4% (111/212), and that for adenocarcinoma was 69.7% (106/152). A favorable submission rate and success rate of multi-gene panel tests were shown, along with a favorable detection rate in recent clinical settings.
Comparative Evaluation of New Needleless Local Anesthetic System (INJEX) and Conventional Syringe Needle Technique during Pulpotomy Treatment: A Randomized Clinical Trial
Authors: Vishwanathaiah Satish , Albar Nassreen H. , Alraghi Fatemah Tawfeg Abkar , Jaferi Noor Eissa Mousa , Tumayhi Ishraq Abdullah Mohammed , Panda Suman , Khormi Fatima Ali Hassan , Jaafari Atlal Hassan Hussain , Abiri Zahra Ahmed Ibrahim , Maganur Prabhadevi C.
Published: April 2024

Background: The dreaded sensation of pain in the dental chair has a significant impact on children’s behavior. This study aimed to compare and contrast the perception of pain and patient behavior between the use of INJEX and the conventional syringe needle technique during pulpotomy among children. Methods: A randomized clinical trial was designed and conducted among pediatric dentistry patients aged 6–12 years old. Fifty-eight children were divided into two groups, conventional syringe needle and INJEX, using simple randomization method applying the sequentially numbered, opaque, sealed envelope method of allocation concealment. Anesthesia was administered to the groups as local infiltration by a single operator following routine behavior guidance techniques. After 3 min, pulpotomy was performed using the standard protocol. The Face, Legs, Activity, Cry, Consolability (FLACC) scale and Wong–Baker FACES Pain Rating Scale (WBS) were used to assess the intensity of pain, while the Frankl behavior rating scale (FBRS) was used to assess the children’s behavior. Results: During anesthesia, most of the participants in the INJEX group (median = 3) had higher FBRS scores compared with the conventional syringe needle group (median = 2), and the difference was very highly significant (p-value < 0.001). Analyzing the FLACC scores during local anesthesia administration revealed a high statistical significance (p-value < 0.01) across the two groups. A very high statistically significant difference (p-values < 0.001) with higher WBS scores for pain intensity was seen in the group using conventional syringe needles. Conclusions: INJEX administration significantly reduced the intensity of pain experienced by the children and helped maintain a positive attitude among them during pulpotomy. It provided a positive and comfortable experience for both the child and the practitioner. Therefore, it can serve as an excellent alternative to conventional needle anesthesia.
Exploring Independent and Cumulative Effects of Adverse Childhood Experiences on PTSD and CPTSD a Study in Ugandan Adolescents
Authors: Ferrajão Paulo , Frias Francisco , Elklit Ask
Published: April 2024

Exposure to adverse childhood experiences (ACEs) is related to higher morbidity and mortality among adolescents. The present study analyzed the independent and cumulative effects of ACE exposure on the likelihood of PTSD and a CPSTD diagnosis in Ugandan adolescents. A sample of 401 schoolchildren participated in the study. The primary aim was to collect information on ACEs, PTSD, CPTSD, and attachment styles among adolescents living in different countries. It was found that exposure to 2–3 ACEs and exposure to 4–5 ACEs were significantly associated with PTSD diagnosis, while exposure to sexual abuse, bullying, threats of violence, and near-drowning were significantly related to CPTSD diagnosis. Fearful attachment style was significantly associated with PTSD diagnosis. The results propose that biological, psychological, and social issues interact and contribute to the differential prevalence of ACE, attachment styles, and PTSD/CPTSD. This study underscores the importance of addressing childhood-averse and traumatic experiences as a public health priority in Uganda.
Still an Unsolved Question: The Place of Cranial Magnetic Resonance Imaging in Acute Acquired Concomitant Esotropia
Authors: Mittendorf Luisa , Bernhard Matthias K. , Sterker Ina , Kiess Wieland , Gburek-Augustat Janina , Merkenschlager Andreas
Published: April 2024

Purpose: The aim of this study was to collect further data to estimate the risk of relevant intracranial pathology and thereby better assess the need for cranial imaging in children with acute acquired comitant esotropia (AACE). To date, there is still not enough literature on this topic to enable a consensus on the diagnostic algorithm. Methods: We analyzed data from patients with convergent strabismus who received cranial imaging via magnetic resonance imaging (MRI). Twenty-one patients received a cranial MRI for the diagnostic evaluation of AACE. The age range was from 2 to 12 years, and the mean age at the time of diagnosis was 5.5 years. Of these patients, only one exhibited insignificant MRI findings, with no therapeutic consequences. Conclusions: Our data add further evidence that AACE without neurological findings or other ophthalmologic anomalies might not be an indication for cranial MRI as a diagnostic screening tool.
The Impact of Family Functioning Factors on Smartphone Addiction and Phubbing among Muslim Adolescents in Thailand
Authors: Kim Yejin , Dhammasaccakarn Wanchai , Laeheem Kasetchai , Rinthaisong Idsaratt
Published: April 2024

Background: While there is research on protective factors against smartphone addiction (SA) and phubbing, which impact adolescents’ physical, psychological, interpersonal, and academic well-being, focused studies on these issues among Thai Muslim students in Southern Thailand remain scarce. Objectives: To bridge this gap, this research aimed to explore the influence of five family functioning factors—discipline, communication and problem-solving (CPS), relationship, emotional status, and family support—guided by family systems theory and the McMaster Model, on SA and phubbing. Methods: Data from 825 Thai Muslim adolescent secondary school students (Female N = 459 (55.7%), Mage = 15.11 ± 1.78) across three southern Thai provinces were analyzed utilizing structural equation modeling (SEM). Results: Significant connections were identified between family functioning factors, particularly emotional status and discipline, and SA, and their impact on phubbing behavior. SA was found to mediate the relationship between these two family factors and phubbing. Interestingly, a higher quality of family relationships was found to be associated with an increased risk of SA, while the other two family functions—CPS and family support—demonstrated no significant association with these digital behaviors. Conclusions: Despite its limitations, including a cross-sectional design and reliance on self-reports, the study underscores the importance of specific family functions in preventing and addressing adolescent SA and phubbing.
Conceptualising the Link between Citizen Science and Climate Governance: A Systematic Review
Authors: Freschi Gloria , Menegatto Marialuisa , Zamperini Adriano
Published: April 2024

Multilevel and decentralised governance approaches involving different social actors are increasingly relevant to collectively tackling climate-induced vulnerabilities. Among emergent governance experimentations, citizen science (CS) is a transversal scientific practice characterised by the involvement of citizens in various phases of the scientific process. We performed a PRISMA systematic review of the scientific literature in order to conceptualise the interface between CS and climate governance. The included 44 studies were coded following the thematic analysis method. Information about temporal and geographical distribution, main research designs and methods, climate governance domains and levels of analysis was extracted. Among the most significant results, we stress the existence of a two-way link between CS and climate governance: CS beyond data gathering can facilitate climate change adaptation—namely, counteracting disaster risk, food insecurity and mental health distress due to changing climate, promoting health and wellbeing, and environmental conservation—until systemic changes are made. Conversely, inclusive governance structures and processes may provide support to initiate CS projects. We also discuss the role of psychosocial and justice issues—as well as digital CS—throughout the selected literature, and the implications for future lines of research and policy.
Surface-Enhanced Raman Scattering for Probe Detection via Gold Nanorods and AuNRs@SiO2 Composites
Authors: Li Huiqin , Tian Yanyu , Yan Shaotian , Ren Lijun , Ma Rong , Zhao Weiwei , Zhang Hongge , Dou Shumei
Published: April 2024

In this paper, a self-assembly method was used to prepare gold nanorod composites, and a seed-growth method was used to adjust the amount of AgNO3 solution, enabling the preparation of gold nanorods with different aspect ratios. AuNRs@SiO2 nanocomposite particles were then prepared by using the Stöber method to coat the gold nanorod surface with silica. Transmission electron microscopy showed that the maximum aspect ratio of the gold nanorods was 4.53, which was achieved using 2 mL of 10 mM AgNO3 solution. The Raman-scattering intensity of the gold nanorods was studied using rhodamine 6G, thiram, melamine, and piroxicam, and detection limits of 10−8 M, 10−5 M, and 10−3 M were, respectively, achieved. As a substrate, these gold nanorods showed good repeatability and reproducibility, and trace detection was successfully achieved. A transmission electron microscopy analysis shows that the SiO2 shell became thicker with increasing tetraethyl orthosilicate addition. Using AuNRs@SiO2 as the base and R6G, thiram, and piroxicam as the probes, measurable detection limits of 10−9 M, 10−6 M, and 10−5 M were achieved, and this composite also showed excellent repeatability and reproducibility.
Photocatalytic Activities of Methylene Blue Using ZrO2 Thin Films at Different Annealing Temperatures
Authors: Acosta-Silva Yuliana de Jesús , Gallardo-Hernández Salvador , Rivas Sandra , Espejel-Ayala Fabricio , Méndez-López Arturo
Published: April 2024

Tetragonal ZrO2, synthesized by the sol–gel method and dip-coating technique, was found to be photocatalytically active for the degradation of methylene blue. The ZrO2 thin films were characterized by X-ray diffraction (XRD), Raman spectroscopy, Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and UV-vis spectroscopy. The photocatalytic degradation of methylene blue was carried out with this material. We identified the tetragonal phase in ZrO2 thin film at different annealing temperatures from 400 °C to 550 °C. The XRD study indicated that the films were monocrystalline in nature with preferred grain orientation along (011) plane and exhibited a tetragonal crystal structure. The crystallite size of the films increased with increasing annealing temperature. FTIR explained the bonding nature and confirmed the formation of the composite. UV-Vis showed the optical absorbance was high in the visible region and the optical band gap value increased with annealing temperature. The photocatalytic experimental results revealed that ZrO2 thin films degraded MB by 20%, 24%, 29%, and 36%, with annealing temperatures of 400 °C at 550 °C for 10 h, respectively. Our results provide useful insights into the development of photocatalytic materials and degradation of methylene blue.
Screening of Complex Layered Chalcogenide Structures as High-Performance Thermoelectrics by High-Throughput Calculations
Authors: Tian Jing , Ma Weiliang , Carenzi Manuela , Boulet Pascal , Record Marie-Christine
Published: April 2024

Thermoelectric materials have drawn much attention over the last two decades due to the increase in global energy demand. However, designing efficient thermoelectrics reveals itself as a tough task for their properties (Seebeck coefficient, electrical conductivity, thermal conductivity) are mutually opposed. Hence, most recently, new design approaches have appeared, among which high-throughput methods have been implemented either experimentally or computationally. In this work, a high-throughput computer program has been designed to generate over 4000 structures based on a small set of complex layered chalcogenide compounds taken from the mAIVBVI nA2VB3VI homologous series, where AIV is Ge, AV is Sb and BVI is Te. The computer-generated structures have been investigated using density-functional theory methods, and the electronic and transport properties have been calculated. It has been found, using the quantum theory of atoms in molecules and crystals, that a wide variety of bond types constitutes the bonding network of the structures. All the structures are found to have negative formation energies. Among the obtained final structures, 43 are found with a wide band gap energy (>0.25 eV), 358 with semi-conductor/metal characteristics, and 731 with metallic characteristics. The transport properties calculations, using the Boltzmann equation, reveal that two p-type and 86 n-type structures are potentially promising compounds for thermoelectric applications.
Optimizing Oxygen Delivery by Low-Flow Nasal Cannula to Small Infants: A Bench Study
Authors: Bertzouanis Aris , Sinopidis Xenophon , Pelekouda Polyxeni , Karatza Ageliki , Dimitriou Gabriel , Fouzas Sotirios
Published: April 2024

Background: In infants treated with a low-flow nasal cannula (LFNC), the oxygen concentration delivered to the lungs (i.e., the effective FiO2) is difficult to estimate. The existing mathematical formulas rely on important assumptions regarding the values of respiratory parameters and, thus, may be inaccurate. We aimed to assess oxygen delivery by LFNC to small infants using realistic simulations on a mechanical breathing model. Methods: A mechanical breathing simulator (infant upper-airway replica, single-space breathing compartment, electric motor, microcontroller) was developed. Breathing simulations (n = 1200) were performed at various tidal volume (VT), inspiratory time (Ti), and respiratory rate (RR) combinations and different cannula flows. Results: Minute ventilation (MV) was the most significant predictor of effective FiO2. FiO2 was higher at lower VT and higher Ti values. Benaron and Benitz’s formula underestimated the effective FiO2 at lower MV values, while Finer’s formula significantly overestimated it. A set of predictive FiO2 charts was developed based on cannula flow, infant body weight, and RR. Conclusions: The effective FiO2 delivered by LFNC to small infants critically depends on VT, Ti, and RR. However, since VT and Ti values are not available in clinical practice, the existing mathematical formulas may be inaccurate. Our novel predictive FiO2 charts could assist in optimizing oxygen delivery by LFNC using easy-to-obtain parameters, such as infant body weight and RR.
The Detection of Pulp Stones with Automatic Deep Learning in Panoramic Radiographies: An AI Pilot Study
Authors: Altındağ Ali , Bahrilli Serkan , Çelik Özer , Bayrakdar İbrahim Şevki , Orhan Kaan
Published: April 2024

This study aims to evaluate the effectiveness of employing a deep learning approach for the automated detection of pulp stones in panoramic imaging. A comprehensive dataset comprising 2409 panoramic radiography images (7564 labels) underwent labeling using the CranioCatch labeling program, developed in Eskişehir, Turkey. The dataset was stratified into three distinct subsets: training (n = 1929, 80% of the total), validation (n = 240, 10% of the total), and test (n = 240, 10% of the total) sets. To optimize the visual clarity of labeled regions, a 3 × 3 clash operation was applied to the images. The YOLOv5 architecture was employed for artificial intelligence modeling, yielding F1, sensitivity, and precision metrics of 0.7892, 0.8026, and 0.7762, respectively, during the evaluation of the test dataset. Among deep learning-based artificial intelligence algorithms applied to panoramic radiographs, the use of numerical identification for the detection of pulp stones has achieved remarkable success. It is expected that the success rates of training models will increase by using datasets consisting of a larger number of images. The use of artificial intelligence-supported clinical decision support system software has the potential to increase the efficiency and effectiveness of dentists.
Validation of a New Duplex Real-Time Polymerase Chain Reaction for Chlamydia trachomatis DNA Detection in Ocular Swab Samples
Authors: Favacho Joana da Felicidade Ribeiro , Leite Keren Kariene , Jacomasso Thiago , Farias Aline Burda , Franco Filho Luciano Chaves , Gomes Samara Tatielle Monteiro , dos Reis Herald Souza , Mota Gardene Dourado , Schluga Pedro Henrique de Caires , Tassi Walleyd Sami , Rampazzo Rita de Cássia Pontello , West Sheila Kay , Gaydos Charlotte Ann , da Cunha Antonio José Ledo Alves , Costa Alexandre Dias Tavares
Published: April 2024

Trachoma is the world-leading infectious cause of preventable blindness and is caused by the bacteria Chlamydia trachomatis. In developing countries, diagnosis is usually based on clinical evaluation. Serological-based tests are cheaper than molecular-based ones, but the latter are more sensitive and specific. The present study developed a new duplex qPCR which concomitantly detects the C. trachomatis cryptic plasmid and the human 18S rRNA gene, with an LOD95% for C. trachomatis DNA of 13.04 genome equivalents per reaction. The new qPCR was tested using 50 samples from an endemic area and 12 from a non-endemic area that were previously characterized using direct immunofluorescence assay (DFA) and clinical evaluation. Among the 50 endemic samples, 3 were found to be positive by clinical evaluation (6%), 18 were found to be positive by DFA (36%), and 48 were found to be positive by qPCR (96%). Next, the new duplex qPCR was validated using 50 samples previously characterized by qPCR. Validation was carried out on a benchtop instrument (ABI7500) or on a portable point-of-care instrument (Q3-Plus), showing 95% specificity and 100% sensitivity. The ubiquitous presence of C. trachomatis DNA in samples from the endemic region confirms that constant monitoring is of paramount importance for the effective measurement of the elimination of trachoma. The newly developed duplex qPCR presented in this study, along with its validation in a portable qPCR system, constitutes important tools toward achieving this goal.
Association of Serum Levels and Immunohistochemical Labelling of Des-Gamma-Carboxy-Prothrombin in Patients Undergoing Liver Transplantation for Hepatocellular Carcinoma
Authors: Chabert Suzanne , Iesari Samuele , Dahlqvist Geraldine , Komuta Mina , Baldin Pamela , Favi Evaldo , Coubeau Laurent
Published: April 2024

Hepatocellular cancer (HCC) is one of the main reasons for liver transplantation (LT). Biomarkers, such as alpha-foetoprotein (AFP) and Des-gamma-carboxy-prothrombin (DCP), can be helpful in defining the recurrence risk post LT. This study aims to evaluate the association between the intensity of DCP immunohistochemical labelling and serum DCP levels in patients undergoing LT for HCC. We carried out a prospective monocentric study including patients who all underwent LT for cirrhosis between 2016 and 2018 and all fell under the Milan criteria. The accepted diagnostic criteria for HCC were contrast-enhanced imaging and histology. Thirty-nine patients were followed for a median of 21 months, with HCC lesions categorized into negative, focally positive, and diffusely positive groups based on DCP immunohistochemistry. The serum DCP levels were significantly higher in the positive groups (258 mAU/mL for the focally and 257 mAU/mL for the diffusely positive) than in the negative group (48 mAU/mL) (p = 0.005) at diagnosis and at the time of liver transplantation (220 mAU/mL for the diffuse positive group). Microvascular invasion (58.8% vs. 19.0% for the diffusely positive and negative groups, respectively, p < 0.001) and lesion size (20 mm in the diffusely labelled group versus 12 mm in the other groups, p = 0.002) were significantly correlated with DCP labelling. Late recurrence occurred only in the positive groups; in the negative group, it occurred within the first 3 months after transplantation. DCP labelling in liver lesions correlates with serum levels and a more aggressive tumour profile. Further investigation is needed to determine if highly DCP-labelled tumours allow for the better selection of high-risk patients before LT.
Pulmonary Hypertension Detection Non-Invasively at Point-of-Care Using a Machine-Learned Algorithm
Authors: Nemati Navid , Burton Timothy , Fathieh Farhad , Gillins Horace R. , Shadforth Ian , Ramchandani Shyam , Bridges Charles R.
Published: April 2024

Artificial intelligence, particularly machine learning, has gained prominence in medical research due to its potential to develop non-invasive diagnostics. Pulmonary hypertension presents a diagnostic challenge due to its heterogeneous nature and similarity in symptoms to other cardiovascular conditions. Here, we describe the development of a supervised machine learning model using non-invasive signals (orthogonal voltage gradient and photoplethysmographic) and a hand-crafted library of 3298 features. The developed model achieved a sensitivity of 87% and a specificity of 83%, with an overall Area Under the Receiver Operator Characteristic Curve (AUC-ROC) of 0.93. Subgroup analysis showed consistent performance across genders, age groups and classes of PH. Feature importance analysis revealed changes in metrics that measure conduction, repolarization and respiration as significant contributors to the model. The model demonstrates promising performance in identifying pulmonary hypertension, offering potential for early detection and intervention when embedded in a point-of-care diagnostic system.
Target Role of Monocytes as Key Cells of Innate Immunity in Rheumatoid Arthritis
Authors: Salnikova Diana I. , Nikiforov Nikita G. , Postnov Anton Y. , Orekhov Alexander N.
Published: April 2024

Rheumatoid arthritis (RA) is a chronic, systemic, and inflammatory autoimmune condition characterized by synovitis, pannus formation (with adjacent bone erosion), and joint destruction. In the perpetuation of RA, fibroblast-like synoviocytes (FLSs), macrophages, B cells, and CD4+ T-cells—specifically Th1 and Th17 cells—play crucial roles. Additionally, dendritic cells, neutrophils, mast cells, and monocytes contribute to the disease progression. Monocytes, circulating cells primarily derived from the bone marrow, participate in RA pathogenesis. Notably, CCR2 interacts with CCL2, and CX3CR1 (expressed by monocytes) cooperates with CX3CL1 (produced by FLSs), facilitating the migration involved in RA. Canonical “classical” monocytes predominantly acquire the phenotype of an “intermediate” subset, which differentially expresses proinflammatory cytokines (IL-1β, IL-6, and TNF) and surface markers (CD14, CD16, HLA-DR, TLRs, and β1- and β2-integrins). However, classical monocytes have greater potential to differentiate into osteoclasts, which contribute to bone resorption in the inflammatory milieu; in RA, Th17 cells stimulate FLSs to produce RANKL, triggering osteoclastogenesis. This review aims to explore the monocyte heterogeneity, plasticity, antigenic expression, and their differentiation into macrophages and osteoclasts. Additionally, we investigate the monocyte migration into the synovium and the role of their cytokines in RA.
Immunohistochemistry as a Reliable Tool for the Diagnosis of Cystic Echinococcosis in Patients from Sardinia, Italy—A Confirmatory Study
Authors: Santucciu Cinzia , Peruzzu Angela , Fara Antonella Maria , Cossu Antonio , Kronenberg Philipp A. , Deplazes Peter , Masala Giovanna
Published: April 2024

Cystic Echinococcosis (CE) is a zoonotic disease caused by the larval stage of the tapeworm Echinococcus granulosus sensu lato (s.l.). This study aims to investigate the use of two monoclonal antibodies (mAbEmG3 and mAbEm2G11) by immunohistochemistry (IHC) to confirm the diagnosis of CE in human patients, in particular in those cases in which other techniques fail to provide a correct or conclusive diagnosis. For this purpose, a survey on 13 patients was performed. These subjects were referred to Sardinian hospitals (Italy) from 2017 to 2022 and were suspected to be affected by CE. Our findings from these 13 patients showed the detection of E. granulosus sensu stricto by IHC in 12 of 13 echinococcal cysts, as one sample was of a non-parasitological origin. The results confirmed that IHC, by means of the mAbEmG3 and mAbEm2G11, is a reliable diagnostic tool that showed a very high performances when tested on strain of E. granulosus s.l. from Sardinia.