bluuebunny/crossref_metadata_2025 huggingface dataset:
[Using Information Technology to Increase the Quality of Financial Statement Data in the Modern Environment]
Authors:   Associate Professor of Financial Accounting, Al-Taweel Dr. Issam Mohammed , Humaid Dr. Mohannad Hassan ,   Assistant Professor of Accounting and Auditing
Published: January 2025

Abstract:

The integration of information technology (IT) in accounting and auditing has become a significant aspect of contemporary business practices, leading to its extensive usage and advancement. This progress has resulted in an upsurge of information requiring effective processing, storage, retrieval, and display across various forms and applications. This study aimed to investigate the role of IT in enhancing the quality of financial statement data in the contemporary business environment. The hypotheses of the study were tested through a field study, involving a sample of internal auditors, directors of the Internal Audit Department, and heads of the Internal Audit Departments from auditing firms and banks within the Gaza Strip.
Perancangan Sistem Informasi Pemesanan Menu Makanan Pada Rumah Makan Permata Minang Berbasis Web
Authors: S Angela Fadilla , Devita Prisilla Maharani  , Nabila Latifah  , Wina Novita Br Bangun  , Heri Kurniawan
Published: January 2025

Rumah Makan Permata Minang  merupakan tempat usaha yang menyajikan menu masakan khas minang yang dijual secara umum kepada masyarakat untuk menikmati hidangan masakan khas minang tersebut. Selama ini, proses pemesanan menu dilakukan secara manual. Dari proses tersebut dapat menimbulkan beberapa masalah, seperti: pelanggan yang kurang puas akan layanan pegawai, tidak dapat mengetahui ketersediaan menu makanan, kesalahan dalam penyajian dan kesalahan dalam proses pembayaran. Penelitian ini bertujuan untuk membantu jika pelayanan dalam rumah makan tersebut tidak maksimal. Oleh karena itu, dibuatlah sistem pemesanan menu makanan berbasis website yang memudahkan para pelanggan untuk memesan menu makanan tanpa harus ngantri ataupun keluar rumah.
Rancang Bangun Aplikasi Kelompok Tani Ternak Kesuma Berbasis Web
Authors: Ricky Ramadhan Harahap  , Irwan  , Supiyandi  , Fajar Ryanda
Published: January 2025

Kelompok Tani Ternak Kesuma masih melakukan pembukuan dan informasi secara manual, yang membuatnya kurang efektif karena kesalahan yang sering terjadi antara pengurus dan gudang. Aplikasi berbasis web mempermudah pemrosesan dan pengiriman data, membantu para kelompok tani mengelola dan mengawasi strategi perusahaan untuk menyesuaikannya dengan pemberdayaan kelompok tani secara seimbang. Karena itu, penelitian ini bertujuan untuk merancang aplikasi kelompok tani yang beroperasi melalui internet. Studi ini menghasilkan aplikasi kelompok tani yang dibangun yang memiliki fitur manajemen yang memungkinkan pembuatan, pembacaan, perubahan, dan penghapusan (CRUD) stok barang, data anggota, stok alat, dan laporan. Namun, petani memiliki kemampuan untuk melihat stok barang dan mengajukan pengambilan secara online. Metode perancangan waterfall berbasis web digunakan dalam proses pengembangan. Metode black box kombinasi dengan teknik Partitioning Test Case Equivalence menghasilkan hasil pengujian perangkat lunak yang berhasil. Aplikasi ini diharapkan dapat membantu Kelompok Tani Ternak Kesuma bekerja lebih baik, meningkatkan solidaritas dan kualitas pangan bagi seluruh petani.
Inclusive Talent Development as A Key for Talent Management and Talent Retention to Achieve Sustainable Human Resource Management in Rural Bank Sharia Indonesia
Authors: Setiawati Anindya Prastiwi , Mujanah Siti , . Sumiati
Published: January 2025

The aim of this research is to analyze inclusive talent development as the main factor in talent management and retention in order to achieve sustainable human resources at rural bank sharia. This research uses a qualitative case study method with propositional outcomes as research results. Interviews and documentation studies were used to collect data. The research results show that inclusive talent development practices not only influence individual growth but also play an important role in retaining talent within the organization. Aspects such as talent identification, focus on technical and generic competencies, as well as retention strategies such as career paths, promotions and increasing compensation according to position level are included in inclusive talent development. This conclusion describes a strategic and holistic view of sustainable human resource management at rural bank sharia, where the focus on talent development creates a work environment that supports, inspires and retains talent for company sustainability and success in a long term.
Management Performance Evaluation of Nonprofit Organizations. Case Study on Sports Organizations
Authors:   George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mureș, Hajdu Doina , Siposné Nándori Eszter ,   2University of Miskolc, Hungary, Zsidó Kinga Emese ,   George Emil Palade University of Medicine, Pharmacy, Science, and Technology of Targu Mureș
Published: January 2025

The economic growth and the standard of living, in addition to the undeniable advantages, also
brought negative changes in the lives of everyday people: transport accessibility and the online
possibilities to perform countless tasks led to convenience in the daily physical movement of the
population, which has the effect of increasing sedentarism. This trend has serious effects on physical
and mental health, so it is essential to understand the impact of physical activity on health and promote
an active lifestyle. Nonprofit organizations such as sports associations have a major role in promoting
a healthy lifestyle. Evaluating sports nonprofit organizations and their performance is essential to
understanding the real impact they have on communities and the promotion of sport. This article aims
to evaluate the performances of some non-profit sports organizations from the Central region of
Romania, using the SWOT and Balanced Scorecard methods. The evaluation results reveal the
existence of chronic insufficiency of material resources and managerial expertise. These organizations
face difficulties in achieving their goals and ensuring the sustainability of their activities.
MULTIPLE FIBROID IN COMBINATION WITH SYNDROME MAYER-ROKITANSKY-KÜSTER-HAUSER: CLINICAL CASE
Authors: MARKOVSKAYA T.V. , ERSHOVA L.I. , SKRYPNIK M.I. , KARPOVICH E.G.
Published: January 2025

Mayer-Rokitansky-Küster-Hauser syndrome (MRKH) is characterized by congenital aplasia of the uterus and upper two-thirds of the vagina, has a female karyotype of 46 XX and an incidence of 1 in 5000 newborn girls. This article presents a rare case of a combination of MRKH syndrome with the most common gynecological pathology, uterine fibroids. Delayed 141 diagnosis of a mass in the pelvis in a patient with a malformation of the internal genital organs led to tumor growth and expansion of surgical access at the stage of surgical treatment.
EXPERIENCE IN MANAGEMENT OF OMPHALOCELE IN NEWBORNS
Authors: ZAPALIANSKI A.V. , NOVOSELTSEVA Y.A.
Published: January 2025

Omphalocele is one of the most common congenital abdominal wall defects. The management of patients with giant omphalocele remains a difficult problem. The size of the defect and the severity of the associated anomalies determine the overall morbidity and mortality. The purpose of this study is to carry out an analysis and comparative assessment of the effectiveness of surgical treatment of 10 newborns with different size of omphalocele and to determine the dependence of outcomes on the presence of viscero-abdominal disproportion. Primary abdominoplasty was performed in 6 patients with small and medium-sized omphalocele. In 4 patients with giant omphalocele, two-stage surgical correction was performed using an active traction system. There were no fatal outcomes. The aesthetic result of the treatment was satisfactory. Multicomponent assessment of intra-abdominal pressure in the postoperative period helps to prevent the development of severe postoperative complications.
LEIGH SYNDROME IS SUBACUTE NECROTIZING ENCEPHALOMYELOPATHY (A CLINICAL CASE)
Authors: ZINOVKINA N.S.
Published: January 2025

Leigh syndrome is a systemic mitochondrial disease caused by mutations in the genes responsible for the synthesis of polypeptides that are part of the complexes of the mitochondrial respiratory chain, as well as proteins involved in the process of their assembly. 262 The clinical differential diagnosis of mitochondrial diseases is one of the most difficult in pediatric neurology. This article examines a case of clinical observation of a child diagnosed with subacute necrotizing encephalomyelopathy. The clinical symptoms of the disease are described, as well as the results of laboratory and instrumental studies that were conducted to clarify the diagnosis.
ROLE OF NEONATAL HEMOSTASIS IN PERINATAL CNS LESION (CLINICAL CASE)
Authors: LEMESHKO YU.I. , ARTSIUSHEYSKAYA M.V. , RUSAK A.A.
Published: January 2025

Intraventricular hemorrhage, despite the evolution of neonatal care, is one of the causes of morbidity and mortality among premature infants. This pathology can lead to various neurological disorders with subsequent disability of the child. The use of platelet indices will improve the assessment of the neonatal hemostasis system and implement a differentiated approach to providing medical care to premature infants with hemorrhagic disorders. The article presents a clinical observation of a premature newborn child S. with intraventricular hemorrhage, which describes a decrease in the total number of platelets, an increase in the number of large platelets, an increase in the relative number of immature platelets in the general blood test.
Capital markets need a new operating model : Built on data, delivered by people
Authors: Maxfield James
Published: January 2025

Capital markets companies are in the midst of a series of challenges that they cannot solve with revenue growth. This has increased the impetus for companies to look inwards and think about efficiencies and cost savings. The operating model that serves capital markets — and the legacy technology that powers it — is struggling to keep up, but change has historically been fraught with risk and the chance of failure looms large. This paper explores the need for a ‘next-generation’ operating model, the transformation pitfalls companies need to avoid when delivering one, the technology that enables it, and why people and data must be at the heart of any change.
Driving growth in asset management through data: Data as a revenue driver
Authors: Cuthbertson Ryan
Published: January 2025

The asset management industry is dealing with a variety of challenges, ranging from difficult market conditions, higher operating costs, declining fees, intensifying competition from passive funds, right through to the introduction of new and complex regulations. At the same time, asset managers are also looking for innovative ways to diversify their businesses, either by launching private fund strategies aimed at the retail market or integrating environmental, social and governance (ESG) standards into their decision-making processes, to name just a few. All these dynamics are forcing asset managers to rethink their historic operating models. If companies are to adapt, however, then they will need access to excellent data. The problem is that many asset managers do not possess this data themselves, or if they do, it is often unstructured and unusable. This is where their global custodians are well positioned to help them. With many global custodians sitting on mountains of data, leading providers are now sanitising this information and turning it into useful insights and analytics for their institutional clients. From this, asset managers will be able to enhance their asset allocation processes, streamline operations, better comply with regulations and ESG requirements and bolster their retail distribution capabilities. In today’s highly crowded market, the ability to successfully make use of data could be the difference between winning and losing lucrative mandates.
Enhancing the inclusion of all pupils: A consequence of a community of philosophical inquiry
Authors: GIAMAKIDOU ELISSAVET
Published: January 2025

This article presents the results of qualitative research conducted in a public primary school, investigating whether the formation of a community of inquiry and the work of children within it, according to its governing principles, can constitute an inclusive practice. By referring to international literature, the article attempts to clarify the concepts of Philosophy for/with Children (P4C), the Community of Philosophical Inquiry, and inclusion. The research results showed that P4C was able to promote the principles of inclusion within this sample. Students, regardless of their performance, socio-economic background, or learning profile, had the opportunity to coexist, communicate, interact, discuss, disagree, agree, and collaborate.
Synergy of Parents and Christian Early Childhood Teachers: Efforts to Prevent the Negative Influence of Social Media on Early Childhood
Authors: Zai Suardin
Published: January 2025

This study discusses the cooperation between parents and Christian PAUD teachers in protecting early childhood from the negative impacts of social media. In this digital era, children are easily exposed to negative content that can affect their development. Synergy between parents and teachers is the key to providing proper education and supervision, so that children can use social media wisely and adhere to Christian values. Therefore, the purpose of writing this article is to provide knowledge discourse to readers, academics, and practitioners to explain the importance of synergy between parents and Christian PAUD teachers in preventing the negative influence of social media on early childhood. The method used in this study is a literature study method with a descriptive qualitative approach through books, journal articles, and websites as references in data collection. The results of this study are parents as the foundation in building children's awareness, while teachers play a complementary role through the transfer of knowledge so that children's innocence can be filled with knowledge and instilling spiritual character for them which can be achieved through synergy between parents and teachers in supporting child development, and especially in preventing the increasingly widespread negative impacts of social media
REPOTENCIAÇÃO DE TRANSFORMADORES: UM ESTUDO DE CASO
Authors: Augustinho Tarciso Amaro , Jesus Aurea Messias de , Reis Alan Kardec Candido dos , Guimaraes Emerson Carlos , Borges Daniela Freitas , Castilho Deives Ferreira
Published: January 2025

O presente artigo trata-se de um estudo de caso de repotenciação de um transformador de uma indústria do setor sucroenergético, localizada na cidade de Capinópolis-MG. O objetivo do estudo foi mostrar a importante economia obtida através da repotenciação de transformadores. O transformador repotenciado não estava atendendo mais a demanda de energia, visto que este já está defasado, quando comparado o custo da repotenciação com o custo da troca do transformador, foi decidido pela repotenciação do mesmo. Aplicando o método do levantamento de cargas no campo, foi analisado que seria possível o transformador ganhar de 20% a 25% de potência através de ventilação forçada. De acordo com os resultados obtidos através do levantamento de carga, optou-se por instalar um ventilador em cada aleta do transformador. Após a instalação, verificou-se a eficácia do sistema instalado, sendo muito satisfatórios os resultados e comprovando a eficiência dos transformadores com esse modelo de repotenciação. Então chegou-se a seguinte conclusão que o transformador que antes nos fornecia uma potência nominal de 2500 kVA, passou a nos fornecer uma potência nominal de 3000 kVA, isso gerou um ganho de 20% em relação a sua potência inicial.
Riscos ocupacionais e estratégias de prevenção de lesões por esforços repetitivos (LER/DORT) na indústria: uma visão da medicina do trabalho
Authors: Lippe Marcela Maria Ferreira
Published: January 2025

As Lesões por Esforços Repetitivos (LER) e os Distúrbios Osteomusculares Relacionados ao Trabalho (DORT) representam desafios significativos para a saúde ocupacional na indústria, sendo causados por fatores como movimentos repetitivos, posturas inadequadas, carga de trabalho excessiva e condições ergonômicas precárias. Esses riscos impactam diretamente a saúde física e mental dos trabalhadores, resultando em dor crônica, limitações funcionais, aumento do absenteísmo e presenteísmo, além de comprometer a produtividade e a qualidade de vida. Este estudo teve como objetivo analisar os principais fatores de risco ocupacionais associados às LER/DORT e avaliar estratégias preventivas eficazes, com foco nas práticas da Medicina do Trabalho para promover ambientes laborais mais seguros e saudáveis.   Foi realizada uma revisão integrativa da literatura nas bases PubMed, SciELO, LILACS e Google Scholar, abrangendo publicações de 1992 a 2024. Os resultados destacam que medidas preventivas, como ajustes ergonômicos, redesenho do ambiente de trabalho, adaptação de equipamentos e programas de exercícios físicos, são eficazes na redução da incidência dessas lesões. A atuação da Medicina do Trabalho é fundamental na identificação precoce de fatores de risco e na implementação de estratégias preventivas personalizadas. Conclui-se que a prevenção e o manejo de LER/DORT exigem uma abordagem multidisciplinar, que combine ações organizacionais e individuais. Embora as estratégias preventivas apresentem resultados positivos, são necessários mais estudos para aprimorar as práticas existentes e assegurar ambientes de trabalho mais seguros, promovendo a saúde e a produtividade dos trabalhadores industriais
Encryption of Color Images utilizing cascading 3D Chaotic Maps with S-Box Algorithms
Authors: Ayad Jenan , Ali Guma , Ullah Waheed , Robert Wamusi
Published: January 2025

The fundamental characteristics of chaos, including sensitivity to beginning conditions and unpredictability, render it a prime candidate for cryptographic applications. This research introduces an encryption methodology for effective and safe image encryption. The encryption system has two ciphering phases and a substitution phase. This study proposes a method for key creation. The design of a pseudo-random number generator utilized for key generation is founded on chaotic algorithms. The chaotic map will be employed in encryption systems owing to its superior security. NIST tests are employed to assess the randomness of the proposed PRNG sequences. The subsequent part presents a security study of the suggested picture encryption approach to evaluate its efficacy. The statistical analysis now confirms that the technique is secure and efficient for encrypting both basic and complicated images, whether in monochrome or color. Through a comparison with previous chaotic investigations, it is evident that our method is competitive with earlier efforts.
Giono, au-delà du roman
Authors: Labouret Denis
Published: January 2025

Jean Giono est encore trop souvent considéré comme un romancier traditionnel, comme si son talent de conteur pouvait se plier aux limites d’un genre hérité. C’est méconnaître qu’il est d’abord un inventeur. Avec une curiosité insatiable, il a exploré tous les genres (le poème, l’essai, le pamphlet, la nouvelle, l’autobiographie, la chronique de presse, le théâtre…) et renouvelé l’art du roman lui-même.
Denis Labouret nous le montre dans cet ouvrage : chez Giono l’expérience de l’écriture, confrontée au mystère de l’être et du monde, s’accomplit en rupture avec son temps et engage la manière de raconter des histoires dans des voies inédites et déroutantes.
Au-delà de ses qualités de romancier, Giono est ainsi un écrivain total, qui use de tous les moyens d’expression possibles pour donner forme à sa vision du monde et susciter chez ses lecteurs trouble, curiosité et enchantement.
APPLYING WORD WALL BY STICKY NOTE: A PRACTICES OF MEDIA TO INVOLVE STUDENTS’ WRITING
Authors: Putri Novitasari
Published: January 2025

The objective of this study was to find out whether there was significance impact of word wall for solving students’ problem in writing a descriptive text. By this research researcher applied word wall in form of making sticky note to guide the students to compose sentences about describing place. Quantitative research was implemented as the research design. The sample was 36 students from seventh grade of junior high school. The result of post test showed that the students’ mean score before learned using word wall was 69.2 and reached to 82.5 after the teacher invited them to use ward wall. The result of t-score was 14.92 and the t-table was 3.59. Furthermore, it can be summed up that there was significant effect between word wall and students’ writing.  The increasing of mean score proved that there was improvement on students’ writing in composing descriptive text by applying word wall in sticky notes as the  media for teaching and learning process.
Dalumat ng Inang Bayan at ang Pananaw ni Andres Bonifacio sa Kababaihan
Authors:   University of the Philippines-Diliman, Rodriguez-Tatel Mary Jane
Published: January 2025

The Katipunan was in their discourse of Nation the metaphor of a Mother --
“Inang Bayan.” This intelligent conversation was a response of the “anak ng bayan” in the written discussion of Madre España expanded by the Filipino Ilustrado. The ideology in the discourse of Inang Bayan is inherent to all members of Katipunan. This ideology united the Katipuneros to search for the “kagalingan ni Inang Bayan.” In the final analysis, the Katipunan gave a high preference to define the word nation as the “mother” vis-a vis the “patria” of the west, the value and honor given by the supremo to women.

It’s good to engage the question, why character of a woman was used by
the anak ng bayan to conceptualize the katipunan organization. This research will try to answer this question by presenting the following: first, the socio-cultural context that was responsible in the promulgation of such discourse; second, the perspective of Andres Bonifacio who was the proponent of the said discourse as brain for interpretation.
A Large Class Engagement (LCE) Model Based on Service-Dominant Logic (SDL) and Flipped Classrooms
Authors:   University of Western Australia, Jarvis Wade , Halvorson Wade , Sadeque Saalem , Johnston Shannon
Published: January 2025

Ensuring that university graduates are ready for their professional futures is a complex undertaking that includes, but is not limited to, the development of their professional knowledge and skills, and the provision of empowering learning experiences established through their own contributions. One way to draw these complex processes together for a large undergraduate class setting may be through a teaching and learning framework that centres on engagement. Engagement precipitates deeper learning, based on student-centred knowledge and skills development through co-creation. This conceptual paper proposes the Large Class Engagement model (LCE), which integrates high levels of student cognitive involvement and participation as antecedents to engagement, and treats engagement as a co-creation process between educators and students. The model applies services theory to conceptualise engagement in large flipped classes. The case study in this paper adds a new perspective to higher education. More specifically, it illustrates how a service dominant logic can be used to foster co-creation and thus enhance the learning experiences and outcomes in very large classes.
Flipping the Learning: An Investigation into the Use of the Flipped Classroom Model in an Introductory Teaching Course
Authors:   Florida Atlantic University, Vaughan Michelle
Published: January 2025

With a classroom full of millennial learners, it is essential that teacher educators adjust their pedagogy to meet their students’ needs. This study explores the use of a flipped classroom model to engage preservice teachers in an Introduction to the Teaching Profession course. In addition, it explores the need for teacher education coursework to model innovative teaching strategies, such as flipped classrooms, in an effort to prepare preservice teachers for future students. Results indicated that students displayed a higher level of reflection and inquiry in their coursework and a greater number of instructional strategies were modelled within the course.
Prospect Of Performance Development Sharia Mutual Funds In The Indonesian Capital Market
Authors: Syahputra Aprilian Dwi
Published: January 2025

Investment is one of the efforts to overcome the problems that occur in the Indonesian economy. There are many investment sectors that can be used to invest excess capital or assets. Islamic mutual funds as a form of investment institution innovation from conventional mutual funds have fundamental differences in the management of investor funds, which must be guided by and must not conflict with sharia values. Several mutual fund studies in Indonesia mention that the prospect of developing Islamic mutual funds is experiencing quite good growth both in terms of performance and program. This research uses literature research method. The purpose of this study is to analyze the prospects for the development and growth of Islamic mutual funds in Indonesia. From several previous studies, it is concluded that the development of Islamic mutual funds also has promising economic prospects in the future. Factors that can hinder the development of Islamic mutual funds are caused by the literacy of the general public regarding Islamic mutual funds, where people assume that Islamic mutual fund investments are only for Muslims so that in general people are more likely to choose conventional mutual fund investments when viewed in terms of fund management experience.
Kerala Society and the Dimensions of Ethnicity: A Conceptual Framework
Authors: P. Pratheesh , Reema Mary
Published: January 2025

Kerala is a multiethnic, multilingual, and multireligious state that is located in southern India, between the Arabian Sea and the Western Ghats. The ethnic groups of Kerala society are referred to by the words “Keralite” and “Malayali,” where “Keralite” denotes membership in Kerala society and “Malayali” denotes membership in the linguistic ethnicity. The alteration of pre-colonial social edifices and the impacts of colonialism are contentious issue among sociologists, historians, linguists, cultural anthropologists, and other academics. The relationship between foreign power and transformation is examined in the process of ethnic alteration during colonialism. This study uses a qualitative research approach, combining historical, sociological, and anthropological perspectives to understand the dimensions of ethnicity in Kerala society. The conceptual framework integrates theoretical insights from various disciplines to analyse the complex dynamics of ethnicity in Kerala. The article challenges the distinction between “natural” and “manufactured” ethnicity, emphasizing the boundary-maintenance method as the significant issue in social stratification based ethnic groups; and emphasizes the importance of considering power dynamics and social hierarchies that underpin ethnic relations and how these dynamics shape the experiences of different ethnic groups.
Population Patterns and Heritage: An Empirical Review of Demographic and Cultural Legacies
Authors:   Osmania University, Suryanarayana A. , Ravi Aluvala ,   Mahatma Gandhi University
Published: January 2025

The complicated link between ‘Demographic Continuity’ and the prominence of ‘Cultural Practices’ in India highlights demographic transitions are not only ways to achieve economic development, but also influential drivers that affect social cohesion and cultural identity. Theories of demographic continuity are part postulate and part projection as India experiences immense changes in fertility, migration, and urbanization. Insights into the drivers of demographic continuity are increasingly relevant for both scholars and policy. This necessitates reviewing the empirical literature which illustrates continuity with respect to cultural values despite considerable social and economic perturbation as well as some indications regarding how it navigates these processes. As nations evolve to adapt to contemporary influences, education and intergenerational knowledge transfer about the importance of engagement with culture becomes a national imperative. This entails pinpointing research gaps, especially the lack of longitudinal and interdisciplinary studies that can yield insights from sociology, economics, or public health perspectives. By exploring the relationship between demographic trends and cultural continuity, this Article seeks to facilitate a better understanding of the issues facing India where diversity needs to mature into sensitivity. This is especially so before devising inclusive policies that honor its rich multi-diversity heritage only through tested resolutions against modern challenges.
INTEGRATING PHYTOCHEMISTRY WITH ONCOLOGY: THE ROLE OF ALOE VERA NANOPARTICLES IN COMBATING ORAL CANCER TUMOR GROWTH: IN VIVO RAT MODELS
Authors: Sawera Saleem Khan  , Muhammad Arslan Zaffar  , Soobia Pathan  , Muhammad Sheryar  , Muhammad Akram  , Muhammad Arsalan
Published: January 2025

Background: Oral cancer, a major public health challenge, often exhibits poor prognosis due to resistance to conventional therapies. Integrating plant-derived nanotherapeutics, such as Aloe vera nanoparticles (AVNPs), offers a promising alternative approach. Aloe vera possesses anti-inflammatory, pro-apoptotic, and anti-tumor properties, which can be enhanced through nanoparticle synthesis. This study explores the anti-cancer potential of AVNPs in reducing oral cancer tumor growth using in vivo models.
Objective: To investigate the therapeutic efficacy of Aloe vera nanoparticles in reducing tumor growth and inducing apoptosis in a chemically induced oral cancer rat model.
Methods: Aloe vera gel was processed under aseptic conditions, freeze-dried, and synthesized into nanoparticles using a green synthesis approach. Characterization of AVNPs was performed using Scanning Electron Microscopy (SEM) and Dynamic Light Scattering (DLS). Oral cancer was induced in Sprague-Dawley rats through 4-nitroquinoline 1-oxide (4NQO) in drinking water (20 ppm) over eight weeks. Rats were divided into four groups: control, cancer control, low-dose AVNPs (20 mg/kg), and high-dose AVNPs (40 mg/kg). Tumor growth inhibition was evaluated macroscopically and histopathologically. Cellular viability was assessed using the MTT assay, and gene expression levels of Caspase-3 and Caspase-9 were analyzed through quantitative PCR.
Results: AVNPs exhibited an IC50 of 13.1 µM in the MTT assay. Tumor volume decreased significantly in the treated groups compared to the cancer control group. Relative gene expression showed upregulation of pro-apoptotic markers, with Caspase-3 at 12.3 and Caspase-9 at 14.8. These results confirm enhanced apoptosis and tumor suppression by AVNPs.
Conclusion: Aloe vera nanoparticles demonstrated significant anti-cancer potential by inducing apoptosis and reducing tumor growth in oral cancer models. Their efficacy as natural chemotherapeutics warrants further clinical research for potential therapeutic applications.
What is Music Mediation?
Authors: Petri-Preis Axel , Voit Johannes
Published: January 2025

The article addresses the question of what is actually meant by music mediation. We de-fine music mediation as a broadly diversified artistic-educational practice that fosters diverse relationships between people and music, and subsequently discuss formats, con-texts, and stakeholders involved. After a brief historical excursion, we delve into music mediation as a professional field, debate existing definitions, and conclude the article with an overview of music mediation as a research field.
Sistema móvil para el análisis de estado emocional
Authors: Pazmiño Yánez Kevin , Javier Gualpa Angel , Santacruz Diaz Edison , Santy Pazmiño Galo , Reyes Marquez Alex
Published: January 2025

Este trabajo se centra en el desarrollo de un sistema de reconocimiento facial y análisis emocional en tiempo real, implementado en Python y utilizando diversas bibliotecas especializadas. El mismo que emplea una cámara web para capturar video en vivo, detectar rostros en las imágenes y clasificar las emociones expresadas por las personas. Se prioriza la creación de una visualización en tiempo real, clara y comprensible, que permita el análisis de las expresiones faciales para determinar el estado emocional predominante, además de identificar la presencia de rostros humanos. La combinación de técnicas de visión por computadora, aprendizaje automático y procesamiento de imágenes asegura un análisis preciso y eficiente. Este proyecto tiene implicaciones significativas en campos como la interacción humano-computadora, la seguridad y el marketing, proporcionando una herramienta robusta para la interpretación automática de emociones en diversos contextos. Además, se contempla la integración de algoritmos de aprendizaje profundo para mejorar la precisión y adaptabilidad del sistema. El enfoque en la accesibilidad y la facilidad de uso permitirá una amplia adopción en diversas industrias, optimizando la interacción entre humanos y sistemas automatizados. La implementación de este sistema no solo promete avances tecnológicos, sino también una comprensión más profunda del comportamiento humano a través del análisis emocional, abriendo nuevas posibilidades en la investigación y aplicación de tecnologías emergentes.
Redes sociales principal fuente de información de españoles frente a europeos
Authors: Pastor Rodríguez Ana , De Frutos Torres Belinda
Published: January 2025

El artículo identifica las principales tendencias y posibles diferencias culturales y sociodemográficas que influyen en el hábito de consumo de noticias entre los países europeos que más utilizan las redes sociales: alemanes, franceses, españoles, neerlandeses y portugueses. Se utiliza una metodología cuantitativa a partir de los datos ofrecidos por “Reuters Institute Digital News Report 2023” por lo que se trabaja con una muestra de 10.153 sujetos. Los resultados evidencian la desinformación como un problema complejo dentro de las democracias europeas en el que intervienen conceptos como posverdad, líneas editoriales únicas, desorden periodístico o la alfabetización mediática. Entre los resultados destaca como españoles y portugueses utilizan las redes sociales como fuente de información por delante de alemanes, franceses y neerlandeses. Lo que les expone ante contenidos de menor rigor periodístico. Además, se han encontrado diferencias significativas en cuanto a frecuencia de noticias, interés y confianza hacia éstas atendiendo a la nacionalidad y la edad. A medida que los usuarios envejecen se incrementa el interés por las noticias, consultan está información con más frecuencia y también confían más en el contenido que reciben. Por género los hombres se muestran más interesados y consumen con más asiduidad, sin embargo no existen diferencias significativas en cuanto a la confianza que depositan en la información que reciben. Se aprecia la necesidad de desarrollar campañas nacionales e internacionales que promuevan que los ciudadanos busquen y reciban información de calidad para ejercer una ciudadanía responsable, más allá de su ámbito de confort
Prolactin-mediates a lactation-induced suppression of arcuate kisspeptin neuronal activity necessary for lactational infertility in mice
Authors: Hackwell Eleni , Ladyman Sharon R , Clarkson Jenny , McQullian H James , Boehm Ulrich , Herbison Allan Edward , Brown Rosemary , Grattan David R
Published: January 2025

The specific role that prolactin plays in lactational infertility, as distinct from other suckling or metabolic cues, remains unresolved. Here, deletion of the prolactin receptor (Prlr) from forebrain neurons or arcuate kisspeptin neurons resulted in failure to maintain normal lactation-induced suppression of estrous cycles. Kisspeptin immunoreactivity and pulsatile LH secretion were increased in these mice, even in the presence of ongoing suckling stimulation and lactation. GCaMP fibre photometry of arcuate kisspeptin neurons revealed that the normal episodic activity of these neurons is rapidly suppressed in pregnancy and this was maintained throughout early lactation. Deletion of Prlr from arcuate kisspeptin neurons resulted in early reactivation of episodic activity of kisspeptin neurons prior to a premature return of reproductive cycles in early lactation. These observations show dynamic variation in arcuate kisspeptin neuronal activity associated with the hormonal changes of pregnancy and lactation, and provide direct evidence that prolactin action on arcuate kisspeptin neurons is necessary for suppressing fertility during lactation in mice.
CausalXtract, a flexible pipeline to extract causal effects from live-cell time-lapse imaging data
Authors: Simon Franck , Comes Maria Colomba , Tocci Tiziana , Dupuis Louise , Cabeli Vincent , Lagrange Nikita , Mencattini Arianna , Parrini Maria Carla , Martinelli Eugenio , Isambert Herve
Published: January 2025

Live-cell microscopy routinely provides massive amounts of time-lapse images of complex cellular systems under various physiological or therapeutic conditions. However, this wealth of data remains difficult to interpret in terms of causal effects. Here, we describe CausalXtract, a flexible computational pipeline that discovers causal and possibly time-lagged effects from morphodynamic features and cell–cell interactions in live-cell imaging data. CausalXtract methodology combines network-based and information-based frameworks, which is shown to discover causal effects overlooked by classical Granger and Schreiber causality approaches. We showcase the use of CausalXtract to uncover novel causal effects in a tumor-on-chip cellular ecosystem under therapeutically relevant conditions. In particular, we find that cancer-associated fibroblasts directly inhibit cancer cell apoptosis, independently from anticancer treatment. CausalXtract uncovers also multiple antagonistic effects at different time delays. Hence, CausalXtract provides a unique computational tool to interpret live-cell imaging data for a range of fundamental and translational research applications.
Correlation of Ophthalmic Artery Pulsatility Index with Systolic, Diastolic and Mean Arterial Pressure in Normotensive and Hypertensive Pregnancies: A Cross-sectional Study
Authors: Metya Subha , Goyal Sahil , Madan Manish , Roy Soumit
Published: January 2025

Introduction: Hypertensive disorders complicate 5-15% of pregnancies and are major contributors to maternal and neonatal morbidity and mortality, particularly in cases involving preeclampsia. Affecting approximately 3% of pregnancies, preeclampsia is linked to complications such as preterm birth and low birth weight and is often associated with ocular changes in 30-100% of cases, marked by altered orbital vascular resistance. Traditional blood pressure measurements, while essential, may not fully capture vascular changes, especially in microcirculation, during hypertensive pregnancies. Doppler ultrasonography of the Ophthalmic Artery (OA) provides a non invasive method for assessing these vascular changes. The Ophthalmic Artery Pulsatility Index (OAPI) serves as a measure of vascular resistance in the OA, offering potential as a marker for evaluating and monitoring hypertensive disorders in pregnancy.

Aim: To compare OAPI values between normotensive and hypertensive pregnant women and to analyse the correlation between OAPI and maternal blood pressure parameters.

Materials and Methods: This cross-sectional study was conducted in the Department of Radiology, IQ City Medical College and Hospital, Durgapur, West Bengal, India, from January to August 2023. Systematic random sampling was used to divide participants into three groups: 50 normotensive non pregnant women, 50 normotensive pregnant women and 50 hypertensive pregnant women. The hypertensive group was further subdivided into mild preeclampsia (n=18), severe preeclampsia (n=12), gestational hypertension (n=10) and chronic hypertension (n=10). Doppler ultrasonography was used to measure OAPI and blood pressure parameters, including Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP) and Mean Arterial Pressure (MAP), were recorded. Data analysis employed the Kruskal-Wallis test to compare OAPI values across groups and Spearman’s rho correlation was used to assess relationships between OAPI and blood pressure parameters, with statistical significance set at p<0.05.

Results: The mean age of the subjects was 26.6±5.6 years. The OAPI was notably lower in the hypertensive group at 1.5±0.3, compared to 2.27±0.15 in the normotensive pregnant group and 2.17±0.08 in the normotensive non pregnant group (p<0.05). Within the severe preeclampsia subgroup, the mean OAPI was 1.17±0.14, indicating the highest level of vascular resistance. Strong negative correlations were found between OAPI and blood pressure parameters, with Spearman’s rho values of ρ=- 0.731 (p<0.01) for SBP and ρ=-0.774 (p<0.01) for MAP.

Conclusion: The OAPI proves to be a valuable non invasive marker for detecting and monitoring hypertensive disorders in pregnancy. Its significant inverse correlation with blood pressure parameters highlights its potential for early diagnosis and effective management of hypertensive conditions, particularly severe preeclampsia.
Patterns of Magnetic Resonance Imaging and Early Detection via Diffusion-weighted Imaging of Neonatal Hypoxic Brain Injury: A Cross-sectional Study
Authors: Kumar G Selva , Borah Pronami , Islam Aukifa Khamim Sabibahul , Kashyap Shruti
Published: January 2025

Introduction: Hypoxic-ischaemic Encephalopathy (HIE) is caused by a hypoxic or ischaemic event, resulting in hypoxemia and hypercapnia. Magnetic Resonance Imaging (MRI) is the most sensitive and specific imaging technology for newborns with HIE. Diffusion-Weighted Imaging (DWI) can detect ischaemic changes in the first days after birth.

Aim: To assess various MRI findings and their distribution patterns in neonates with HIE, as well as the importance of DWI in the early detection of HIE.

Materials and Methods: A hospital-based cross-sectional study was performed in the Department of Radiology at Assam Medical College, Dibrugarh, Assam, India over a period of one year, from August 2021 to July 2022. The study included 88 neonates with HIE diagnosed using the Sarnat staging system (stages II and III). The MRI protocol comprised T2-weighted (axial and coronal), T1-weighted (axial), T2 Fluild Attenuated Inversion Recovery (FLAIR) (axial), DWI (axial), Apparent Diffusion Coefficient (ADC) map, and Gradient eco sequences (GRE) (axial). The Analysis of Variance (ANOVA) test or Student’s t-test was used for the association tests for continuous variables, with a p-value <0.05 considered statistically significant.

Results: Most babies underwent MRI between 4 and 7 days of life, and the male-to-female ratio was 1.3:1. The MRI patterns observed included deep grey matter injury in 39 (44%), cortical injury in 17 (19.3%), periventricular injury in 11 (12.5%), and a mixed pattern in 21 (23.9%). The most common patterns observed in preterm and term babies were periventricular leukomalacia and central patterns of injury, respectively. DWI detected ischaemic changes in less than seven-day- old neonates (73.7%) before conventional MRI (50.9%) could identify these changes.

Conclusion: The MRI offers excellent differentiation between grey and white matter and provides a good depiction of the pattern of myelination. MR-DWI adds sensitivity and provides information not seen in the other conventional sequences. MRI can predict severe brain injury in preterm infants who may exhibit less obvious clinical signs of HIE.
Rare Neurological Manifestations of Scrub Typhus: Case Series from a Tertiary Care Centre in Kerala, India
Authors: Salini NR , Sreekumar T Sreena , Ramakrishnan Sudharmma , Srikantan S , Antony Jacob
Published: January 2025

Scrub Typhus has emerged as an important cause of acute febrile illness in various parts of India over the last decade. Scrub Typhus is caused by Orientia tsutsugamushi, a rickettsia transmitted through the bites of infected chigger larvae. The neurological manifestations of Scrub Typhus can be highly variable. The most common neurological manifestation is meningoencephalitis. In addition to two cases of meningoencephalitis, hereby, the authors report three different rare neurological manifestations of Scrub Typhus that presented in the second week of illness. These included isolated sixth cranial nerve palsy, opsoclonus myoclonus, and transient Parkinsonism. All the patients responded to treatment with doxycycline, and authors had to use steroids for one patient with opsoclonus myoclonus. A characteristic eschar was seen in only one patient out of the five cases. Therefore, a high index of suspicion for Scrub Typhus is needed in patients presenting with acute febrile illness and Central Nervous System (CNS) manifestations in endemic areas.
Constraints Faced by Livestock Owners Regarding Livestock Farming in Jabalpur Division of Madhya Pradesh, India
Authors: Paradkar Sarita , Gupta Shobhana , Namdeo Siddharth , Jatav Dileep Kumar , Khan Azlan
Published: January 2025

A study was conducted to identify the constraints faced by livestock owners in Jabalpur Division of Madhya Pradesh. Through multistage random sampling with a sample size of 240 livestock owners. The data were analyzed by Garrett’s technique. The findings of this study indicated that the major constraints faced by livestock owners as per the Garrett’s average score were low cost of milk as compare to the production (50.90%), lack of credit facilities for purchase of feeds, fodders and mineral mixture (47.50%), low price of milk provided by cooperative societies (46.88%), high cost of veterinary treatment (46.32%), unavailability of green fodder round the year (45.12%), poor conception rate (43.09), non availability of diagnostic facilities (42.54%), lack of A.I. facility (42.48%), unaware of heat symptom (42.00), inaduquate supply of vaccines (41.32%) and non availability of essential medicine (40.94).
Investigating Bank Financing and the Financial Performance of Listed Industrial Goods Companies in Nigeria
Authors: Olusegun Akinola, Akinwumi , Kolawole Adegoke, Asimiyu
Published: January 2025

The interplay between the financial constraints and operational realities of manufacturing companies in Nigeria raises critical questions about the effectiveness of bank financing as a tool for enhancing the financial performance of the production companies in Nigeria. The study assessed the effect of bank financing on the financial performance of listed industrial goods companies in Nigeria. Specifically, the study examined the effects of maximum lending rate, bank credits and domestic money supply on the financial performance of listed industrial goods companies in Nigeria between 2014 and 2023. Descriptive and ex-post facto research designs were adopted. The study sample was the population of this study consisting of the 13 listed industrial goods companies in Nigeria using the census sampling method. Ordinary Least Square technique was employed to test the hypotheses. It was found that domestic money supply and banks credit have positive and significant influence on the return on assets. However, outcomes showed that maximum bank lending rate had positive but insignificant influence on ROA. The paper concluded that while bank credits and domestic money supply play crucial roles in enhancing the financial performance of Nigeria's industrial goods companies, the maximum lending rate's impact appears limited. The study recommended among others that banks and other financial institutions should increase the accessibility of credit to industrial goods companies. This can be achieved by developing tailored financial products that meet the specific needs of these companies, thereby supporting their operational and capital expenditure.