bluuebunny/crossref_metadata_2025 huggingface dataset:
A Randomised Controlled Trial of Ice to Reduce the Pain of Immunisation—The ICE Trial
Authors: Ediriweera Yashodha , Banks Jennifer , Hall Leanne , Heal Clare
Published: September 2021

Background and objectives: vaccine injections are a common cause of iatrogenic pain and anxiety, contributing to non-compliance with scheduled vaccinations. With injection-related pain being recognised as a barrier to vaccination uptake in both adults and children, it is important to investigate strategies to effectively reduce immunisation pain. This prospective randomised controlled trial investigated the effects of applying an ice pack on vaccine-related pain in adults. Methods: medical students receiving the flu vaccination were randomised to receive an ice pack (intervention) or placebo cold pack (control) at the injection site for 30 s prior to needle insertion. Immediate post-vaccination pain (VAS) and adverse reactions in the proceeding 24 h were recorded. Results: pain scores between the intervention (n = 19) and control groups (n = 16) were not statistically significant (intervention: median pain VAS = 7.00, IQR = 18; control: median pain VAS = 11, IQR = 14 (p = 0.26). There were no significant differences in the number of adverse events between the two groups (site pain p = 0.18; localised swelling (p = 0.67); bruising p = 0.09; erythema p = 0.46). Discussion: ice did not reduce vaccination-related pain compared to cold packs. COVID-19 related restrictions impacted participant recruitment, rendering the study insufficiently powered to draw conclusions about the results.
A Tribute to Robert (Bob) Sim—Personal Memories of Working in Bob’s Lab
Authors: Williams Samantha , Steinkasserer Alexander
Published: September 2021

This article is intended as a tribute to Robert B. Sim through the sharing of personal memories and anecdotes from two of Bob’s lab members who worked in his lab between 1989 to 1994.
COVID-19 Subunit Vaccine with a Combination of TLR1/2 and TLR3 Agonists Induces Robust and Protective Immunity
Authors: Jeong Soo-Kyung , Heo Yoon-Ki , Jeong Jei-Hyun , Ham Su-Jin , Yum Jung-Sun , Ahn Byung-Cheol , Song Chang-Seon , Chun Eun-Young
Published: September 2021

The development of COVID-19 vaccines is critical in controlling global health issues under the COVID-19 pandemic. The subunit vaccines are the safest and most widely used vaccine platform and highly effective against a multitude of infectious diseases. An adjuvant is essential for subunit vaccines to enhance the magnitude and durability of immune responses. In this study, we determined whether a combination of toll-like receptor (TLR)1/2 and TLR3 agonists (L-pampo) can be a potent adjuvant for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) subunit vaccine. We measured a neutralizing antibody (nAb) and an angiotensin-converting enzyme 2 (ACE2) receptor-blocking antibody against SARS-CoV-2 receptor-binding domain (RBD). We also detected interferon-gamma (IFN-γ) production by using ELISPOT and ELISA assays. By employing a ferret model, we detected nAbs and IFN-γ producing cells and measured viral load in nasal wash after the challenge of SARS-CoV-2. We found that SARS-CoV-2 antigens with L-pampo stimulated robust humoral and cellular immune responses. The efficacy of L-pampo was higher than the other adjuvants. Furthermore, in the ferret model, SARS-CoV-2 antigens with L-pampo elicited nAb response and antigen-specific cellular immune response against SARS-CoV-2, resulting in substantially decreased viral load in their nasal wash. Our study suggests that SARS-CoV-2 antigens formulated with TLR agonists, L-pampo, can be a potent subunit vaccine to promote sufficient protective immunity against SARS-CoV-2.
Effectiveness of a Multifaceted Informational-Based and Text Message Reminders on Pneumococcal and Influenza Vaccinations in Hospital Emergency Departments: A Cluster-Randomized Controlled Trial
Authors: Tubiana Sarah , Labarere José , Levraut Jacques , Michelet Pierre , de Vaux Fleur Jourda , Doumenc Benoit , Hausfater Pierre , Choquet Christophe , Plaisance Patrick , Schmidt Jeannot , Mattei Véronique , Gacia Olivier , Storme Didier , Ray Patrick , Der Sahakian Guillaume , Kouka Marie-Clément , Jainsky Laure , Raude Jocelyn , Duval Xavier , Claessens Yann-Erick
Published: September 2021

Objectives. We aimed to evaluate the effectiveness of a multifaceted procedure in improving pneumococcal and influenza vaccinations 6 months after an emergency department (ED) visit among patients aged 65 years and older. Methods. We conducted a cluster-randomized, controlled, parallel-group, open-label implementation trial in 18 EDs in France and Monaco. Participants were recruited from November 2015 to September 2016. EDs were randomly assigned with a 1:1 ratio to provide either a multifaceted procedure that combined structured information about pneumococcal and influenza vaccines and three text message reminders sent to patients every two weeks (intervention arm) or nonstructured information only (control arm). The outcomes were self-reported pneumococcal vaccination and influenza vaccination rates within 6 months of enrollment. Results. A total of 9 EDs were randomized to the intervention arm (n = 780 patients) and 9 to the control arm (n = 695 patients). The median age for all enrolled patients was 74 years (25–75th percentiles, 69 to 82): 50.1% were male, 34.9% had at least one underlying condition, and 30.7% were at risk for invasive pneumococcal infection. In the intention-to-treat analysis, the multifaceted intervention did not alter the pneumococcal vaccination rate (6.4% versus 4.6%, absolute difference: 1.8; 95% CI: [−0.9 to 4.4]; p = 0.19), whereas it improved the influenza vaccination rate (52.1% versus 40.0%, absolute difference: 12.1; 95% CI: [2.4 to 21.8]; p = 0.01). At 12 months, mortality did not differ between the intervention (9.7%) and control (11.2%) arms (p = 0.35). Conclusions. A multifaceted intervention based on text message reminders provides an opportunity to increase anti-influenza vaccination among elderly patients visiting the ED. Efforts are warranted to provide better information on pneumococcal diseases and the benefits of pneumococcal vaccines, especially in the elderly.
Simultaneous Immunization with Multiple Diverse Immunogens Alters Development of Antigen-Specific Antibody-Mediated Immunity
Authors: Pilewski Kelsey A. , Kramer Kevin J. , Georgiev Ivelin S.
Published: September 2021

Vaccination remains one of the most successful medical interventions in history, significantly decreasing morbidity and mortality associated with, or even eradicating, numerous infectious diseases. Although traditional immunization strategies have recently proven insufficient in the face of many highly mutable and emerging pathogens, modern strategies aim to rationally engineer a single antigen or cocktail of antigens to generate a focused, protective immune response. However, the effect of cocktail vaccination (simultaneous immunization with multiple immunogens) on the antibody response to each individual antigen within the combination, remains largely unstudied. To investigate whether immunization with a cocktail of diverse antigens would result in decreased antibody titer against each unique antigen in the cocktail compared to immunization with each antigen alone, we immunized mice with surface proteins from uropathogenic Escherichia coli, Mycobacterium tuberculosis, and Neisseria meningitides, and monitored the development of antigen-specific IgG antibody responses. We found that antigen-specific endpoint antibody titers were comparable across immunization groups by study conclusion (day 70). Further, we discovered that although cocktail-immunized mice initially elicited more robust antibody responses, the rate of titer development decreases significantly over time compared to single antigen-immunized mice. Investigating the basic properties that govern the development of antigen-specific antibody responses will help inform the design of future combination immunization regimens.
Adjuvants and Antigen-Delivery Systems for Subunit Vaccines against Tuberculosis
Authors: Mustafa Abu Salim
Published: September 2021

The only licensed vaccine against tuberculosis is BCG. However, BCG has failed to provide consistent protection against tuberculosis, especially pulmonary disease in adults. Furthermore, the use of BCG is contraindicated in immunocompromised subjects. The research towards the development of new vaccines against TB includes the use of Mycobacterium tuberculosis antigens as subunit vaccines. Such vaccines may be used either alone or in the prime-boost model in BCG-vaccinated people. However, the antigens for subunit vaccines require adjuvants and/or delivery systems to induce appropriate and protective immune responses against tuberculosis and other diseases. Articles published in this Special Issue have studied the pathogenesis of BCG in children and the use of BCG and recombinant BCG as potential vaccines against asthma. Furthermore, the use of different adjuvants and delivery systems in inducing the protective immune responses after immunization with subunit vaccines has been described.
Claw Characteristics of Culled Sows from Three Farrow-to-Finish Greek Farms. Part 2: Mechanical Indices of Hoof Horn and Their Associations with Length Measurements and Lesion Scores
Authors: Chalvatzi Sofia , Papadopoulos Georgios A. , Kroustallas Fotios , Cernat Mihaela , Skampardonis Vassilis , Marouda Christina , Fotiadou Vasileia , Psychas Vasileios , Poutahidis Theofilos , Leontides Leonidas , Fortomaris Paschalis
Published: September 2021

The objective of the present study was to investigate the mechanical indices of hoof horn and their association with length measurements and lesion score. The feet of 185 culled sows from three Greek farms (A: 57 sows; B: 64 sows; C: 64 sows) were used. A slice from the dorsal wall of each claw was used to assess by a three-point bending test the Young’s modulus, yield stress and aximum stress values. The available data from a companion study (part 1) on the length measurements and lesion scores of the claws were used to reveal possible relationships. The Young’s modulus values were significantly higher (p < 0.001 or p < 0.01 depending on location of claw) in the sows of farm C compared to those in sows of farms A and B and in sows of farm B compared to those in the sows of farm A. Yield and maximum stress values were significantly higher (p < 0.05 or p < 0.001 depending on the location of the claw) in the sows of farm C compared to those in the sows of farm A and in the sows of farm B compared to those in the sows of farm A. An increase in heel-sole length decreased all mechanical indices. Young’s modulus and yield stress were associated with wall lesion severity while maximum stress with wall and heel lesion severity. Overall, we conclude that mechanical efficiency deteriorates as length and lesion score increases.
Antigen-Specific Urinary Immunoglobulin in Reservoir Hosts of Leptospirosis
Authors: Nally Jarlath E. , Hornsby Richard L. , Alt David P.
Published: September 2021

Domestic and wildlife animal species act as reservoir hosts of leptospirosis, a global zoonotic disease affecting more than 1 million people annually and causing significant morbidity and mortality in domestic animals. In contrast to incidental hosts which present with an array of clinical manifestations, reservoir hosts are typically asymptomatic and can shed leptospires from chronically infected kidneys via urine for extended periods of time. Renal excretion of leptospires occurs despite evidence of a humoral and cellular immune response and is reflective of the unique biological equilibrium that exists between certain animal species and specific serovars of Leptospira. Here, we demonstrate that urinary excretion of leptospires is accompanied by the presence of antigen-specific urinary immunoglobulin. In rats experimentally infected with L. interrogans serovar Copenhageni using the intraperitoneal or conjunctival route of inoculation, urinary immunoglobulin (Ig) G specific for protein antigens was detectable within 1 week. Rat urinary IgG was not bound to urinary-derived leptospires. In cattle that were naturally exposed to, and infected with, L. borgpetersenii serovar Hardjo, urinary IgA specific for protein antigens was detected. Collectively, these results demonstrate that urinary excretion of immunoglobulin specific for leptospires is a hallmark of reservoir hosts of infection.
Maculopathy Masquerading as Migraine
Authors: Drayer Turner Laura C. E. , Coebergh Jan A. , Banerjee Philip J.
Published: September 2021

We describe a case of a 23-year-old Caucasian woman with a background history of migraines who presented with bilateral paracentral scotomata. The ophthalmoscopy and MRI head were originally thought to be normal, and the scotomata were attributed to be of migrainous origin: a persistent negative aura. However, persistence of her symptoms prompted further specialist review 10 months later, at which time subtle bilateral perifoveal changes were noted, which had been apparent but overlooked at the initial assessment. Near-infrared reflectance imaging enabled better visualization of the lesions, which were apparent prior to any abnormalities on clinical examination. Spectral-domain optical coherence tomography revealed the early findings of hyperreflectivity in the outer nuclear and outer plexiform layers characteristic of acute macular neuroretinopathy. Our case aims to emphasize the importance of scrutinising ancillary tests of the macula in patients presenting with scotomata or atypical migraine symptoms, and to caution clinicians against diagnosing migraine with persistent negative aura without these investigations.
On-Board Liquid Hydrogen Cold Energy Utilization System for a Heavy-Duty Fuel Cell Hybrid Truck
Authors: Yang Mingye , Hu Song , Yang Fuyuan , Xu Liangfei , Bu Yu , Yuan Dian
Published: September 2021

In this paper, a kind of on-board liquid hydrogen (LH2) cold energy utilization system for a heavy-duty fuel cell hybrid truck is proposed. Through this system, the cold energy of LH2 is used for cooling the inlet air of a compressor and the coolant of the accessories cooling system, sequentially, to reduce the parasitic power, including the air compressor, water pump, and radiator fan power. To estimate the cold energy utilization ratio and parasitic power saving capabilities of this system, a model based on AMESim software was established and simulated under different ambient temperatures and fuel cell stack loads. The simulation results show that cold energy utilization ratio can keep at a high level except under extremely low ambient temperature and light load. Compared to the original LH2 system without cold energy utilization, the total parasitic power consumption can be saved by up to 15% (namely 1.8 kW).
Experience in the use of probiotic drug in pig breeding
Authors: Belookov A. A. , Belookova O. V. , Chukhutin E. V.
Published: September 2021

The results of research on the use of the probiotic drug “Profort” in the diet of young pigs have been presented in the article. The research was carried out under the conditions of LLC “Agrofirma Ariant” on the crossbreds of young pigs. The purpose of the research was to study the eff ectiveness of the effect of the probiotic drug “Profort” in intensive pig rearing on the reproductive traits of sows and the productive traits of piglets. In order to conduct the scientific and economic experiment at the first stage, 2 groups of pregnant sows were formed in each with 10 heads. The feeding and housing of the experimental animals were the same. In addition to the main diet the sows of the experimental group were fed the probiotic additive “Profort” at the dose of 500 g/t of feed for 30 days before and 30 days after farrowing. At the second stage the resulting young animals were divided into 3 groups. In addition to the main diet the young animals of the 1st experimental group have been received the probiotic drug “Profort” from 7 to 105 days together with compound feed. Piglets of the 2nd experimental group have been received the probiotic additive from 7 to 30 days. It has been found during of studies that as a result of the use of probiotic additive the prolificacy of sows in the experimental group was higher – 10,6 compared to 10,4 heads in the control group. The livability of piglets for weaning in the experimental group was 97,9 % compared to 93,9 % in the control group. The absolute gain in live weight of piglets from 30 to 105 days in the experimental groups was 34,94–36,98 kg, which was higher than in the control group by 7,9–14,2 %. In the blood of piglets of the experimental groups, the increase in the level of red blood cells, total protein, calcium and phosphorus has been noted.
Upregulation of prostaglandin E2 by inducible microsomal prostaglandin E synthase-1 in colon cancer
Authors: Kim Young Hun , Kim Kyung Jong
Published: September 2021

Purpose: Prostaglandin E2 (PGE2) is known to promote carcinogenesis and cancer progression in colon cancer. Enzymes involved in the metabolism of PGE2 include cyclooxygenase (COX)-2, microsomal prostaglandin E synthase-1 (mPGES-1), and 15-prostaglandin dehydrogenase (15-PGDH). The current study aims to determine how PGE2 is expressed by examining patients with colorectal cancer and evaluating colon cancer cells to gain insight into changes in relevant enzymes upon induction of PGE2.Methods: The concentration of PGE2 was measured in tumor tissues and adjacent normal mucosal tissues of 26 patients with colon cancer. The expression of COX-1, COX-2, mPGES-1, and 15-PGDH proteins was measured. The concentration of PGE2 in FET colon cancer cells was measured both in the initial status and after stimulation by tumor necrosis factor (TNF)-α. The expression levels of PGE2-related enzymes were measured as well.Results: There was no significant difference in the average concentration of PGE2, which was measured at 453.1 pg/mL in cancer tissues and 401.2 pg/mL in normal mucosa. Among PGE2-related enzymes, 15-PGDH was expressed at a lower level in tumor cells than in normal mucosa. In colon cancer cells, PGE2 was found to be upregulated upon stimulation by TNF-α, which led to strong induction of mPGES-1 without any change in the expression of COX-2 among the PGE2-related enzymes.Conclusion: These results demonstrated that PGE2 can be induced by stimuli such as TNF-α, and suggest that activation of mPGES-1 is more closely related than that of COX-2 in the induction of PGE2 on colon cancer.
Long-term conditions among sexual minority adults in England: evidence from a cross-sectional analysis of responses to the English GP Patient Survey
Authors: Saunders Catherine L , MacCarthy Sarah , Meads Catherine , Massou Efthalia , Mant Jonathan , Saunders Alison M , Elliott Marc N
Published: September 2021

Background

Epidemiological evidence for specific long-term conditions is required to inform best practices regarding the substantial health inequalities experienced by sexual minority individuals compared with heterosexual peers.

Aim

To describe inequalities in long-term conditions among sexual minority (lesbian, gay, and bisexual [LGB]) adults.

Design & setting

Cross-sectional analysis of 1 341 339 nationally representative survey responses from the English GP Patient Survey (GPPS).

Method

Stratifying by sex, the weighted prevalence and covariate-adjusted association of 15 long-term conditions were calculated, comparing sexual minority and heterosexual adults, considering variation by sexual orientation and variation in sexual orientation inequalities by deprivation, ethnic group, region, and age.

Results

After adjusting for deprivation, ethnic group, region, and age, 13 long-term conditions (all except cancer and hypertension) were more prevalent among sexual minority women than their heterosexual peers, with the largest inequalities for mental health problems (odds ratio [OR] 2.8, 95% confidence interval [CI] = 2.7 to 3.0), neurological conditions (OR 1.7, 95% CI = 1.5 to 1.8), dementia (OR 1.6, 95% CI = 1.3 to 1.9), and back problems (OR 1.4, 95% CI = 1.3 to 1.5). It was found that nine long-term conditions were also more prevalent among sexual minority men including mental health problems (OR 2.3, 95% CI = 2.2 to 2.4), 'all other conditions' (OR 1.8, 95% CI = 1.7 to 1.8), neurological conditions (OR 1.5, 95% CI = 1.4 to 1.6), and kidney or liver disease (OR 1.4, 95% CI = 1.3 to 1.5); inequalities were often largest for bisexual adults. Inequalities did not vary significantly by deprivation, ethnic group, or region except for mental health problems. Inequalities in multimorbidity were highest at younger ages; for example, LGB women aged 18–24 years had multimorbidity at the same level (approximately 20%) as heterosexual women aged 45–54 years.

Conclusion

Sexual minority adults, especially bisexual adults, are at elevated risk for many long-term conditions and multimorbidity; this risk spans socioeconomic status and ethnic group, representing a significant healthcare challenge.
Acquired long QT syndrome, manifesting in the first complex after a ventricular extrasystole
Authors: Kononenko O. V. , Zenin S. A. , Fedoseenko A. V. , Felikov I. M. , Pyataeva O. V. , Ermolaeva M. S.
Published: September 2021

A case report of unusual QT interval prolongation after ventricular premature beat is presented.
IX all-russian congress of arrhythmology
Authors: Lebedev D. S. , Popov S. V. , Mikhaylov E. N.
Published: September 2021

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La constitución de la obra de Francisco Urondo en diálogo con la cultura y las formaciones literarias de su tiempo
Authors:   , Gauna Daniela Fernanda
Published: September 2021

La presente tesis estudia los escritos literarios, periodísticos y ensayísticos de Francisco Urondo desde la hipótesis de que la “obra” se configura en diálogo con “prácticas culturales”, “formaciones” y textos literarios de otros autores. Desde esta perspectiva se vinculan las variaciones temáticas y compositivas –las cuales toman diversos matices dependiendo del género– con las prácticas culturales, las formaciones en las que Urondo participó y los textos literarios con los que su obra produce “envíos”. Cabe destacar que el análisis de las formaciones literarias y de las intervenciones culturales es fundamental en tanto éstas son constitutivas de la experiencia desde la cual se trama su escritura. La tesis se organiza en tres capítulos; cada uno da cuenta de modo diferenciado de las relaciones entre escritura, formaciones y prácticas culturales, según tres períodos de producción: 1954-1959; 1960-1969: 1970-1974. Diferencia en la que pervive una “marca” constituida en tres núcleos de sentido: 1. La búsqueda de la expresión literaria que encuentra su fundamento en nombrar aquello que se vincula a su experiencia –situaciones, historia, lugares, lazos afectivos, emociones– a través de una lengua que busca constituirse en relación con modalidades del habla. Decir lo propio se constituye en proceso de indagación en el cual se ensayan diversos modos de resolución según los diferentes géneros por los que transita. En el acercamiento al invencionismo y a la poesía de la zona en la primera etapa, al coloquialismo y realismo en la segunda y al testimonio en la tercera se encuentran delineados los tres recorridos que esta escritura asume. 2. La constitución de un punto de vista centrado en el yo como objeto y sujeto de conocimiento. Siguiendo esta línea, la temática central es la historia en tanto memoria entrelazada al recorrido individual y, en ocasiones, en tanto el yo se yuxtapone a un nosotros construido en términos de generación, el derrotero se torna colectivo. 3. El arte entendido como forma de comunicación entre los hombres y la tarea por parte de los intelectuales de promoverla. Desde sus inicios, la perspectiva de la comunicación estuvo presente en Urondo entendida como potencia del arte en crear vínculos. En esta dirección, son los intelectuales (y del análisis de los textos periodísticos y ensayísticos de este escritor se considera tales a los escritores y artistas que se piensan en relación activa con su contexto) los que deben facilitar que ésta logre realizarse, pues a menudo la capacidad comunicativa es soslayada, interrumpida u obstaculizada por otros factores presentes en la sociedad como la denominada “industria cultural”.
ANALISIS BIAYA KEMACETAN PADA RUAS JALAN TOL JAKARTA-CIKAMPEK KM. 26
Authors: Gunadi Eristian , Nahdalina
Published: September 2021

Kemacetan lalu lintas memberikan dampak negatif yang sangat besar bagi pengguna jalan seperti pemborosan bahan bakar, terbuangnya waktu secara percuma, dan kerusakan lingkungan akibat polusi udara yang dikeluarkan oleh kendaraan bermotor. Oleh karena itu penelitian ini diharapkan dapat menjadi referensi dalam menganalisis besaran kerugian akibat kemacetan. Lokasi yang ditinjau pada penelitian ini yaitu ruas jalan tol Jakarta-Cikampek kilometer 26. Penelitian ini memfokuskan pembahasan pada kerugian berdasarkan biaya operasional kendaraan (BOK) menggunakan pedoman biaya operasi kendaraan Departemen Pekerjaan Umum tahun 2005, biaya waktu perjalanan menggunakan metode income approach untuk penentuan nilai waktu, dan biaya emisi yang mengacu pada Permen LH no.7 tahun 2014 mengenai biaya per unit pencemarannya. Berdasarkan hasil analisis, diperoleh besaran kerugian dari biaya operasional kendaraan (BOK) sebesar Rp.134.725,51/km dengan rincian biaya untuk kendaraan jenis LV sebesar Rp.30.209,10/km, jenis MHV sebesar Rp.26.407,76/km, jenis LB sebesar Rp.27.309,12/km dan jenis LT sebesar Rp.50.799,52. Besaran kerugian berdasarkan biaya waktu perjalanan sebesar Rp.1.907.353,40/jam, dan besaran kerugian berdasarkan biaya emisi sebesar Rp.598.593,03/jam. Sehingga dapat disimpulkan bahwa biaya waktu perjalanan menjadi aspek dengan besaran kerugian tertinggi akibat kemacetan, hal ini dikarenakan aspek ini lebih merepresentasikan nilai dari produktivitas manusia.
Anatomy of Plicadomus sulcatus and taxonomical structure of Mauritian Gibbinae (Gastropoda, Pulmonata, Streptaxidae)
Authors: Schileyko A. A.
Published: September 2021

Gibbinae subfamily in the Mauritius Island is represented by four taxa of generic rank. The anatomy of the type species of three of them has been known previously. The description of the reproductive tract of the fourth - Plicadomus sulcatus (Müller, 1774) is presented. It is shown that under striking conchological differences the anatomy of members of all four taxa is very similar and differs in quantitative characters only (the ratio of the length of the separate elements: the vagina / free oviduct and the relative length of the penis.). On the basis of this fact it was concluded that Mauritian Gibbinae is represented by a single genus Gibbus Montfort, 1810 with four subgenera ( Gonospira Swainson, 1840, Plicadomus Swainson 1840, Gonidomus Swainson, 1840, and Gibbus s. str.).
Distribution of Admete contabulata and Iphinopsis inflata in the Arctic (Gastropoda: Cancellariidae)
Authors: Nekhaev I. O.
Published: September 2021

Only four species of the family Cancellariidae had been reported from the Arctic. However, known distribution of three of them had been limited to the extreme north of the eastern Atlantic so far. The present paper describes findings of Admete contabulata Friele, 1879 from the Barents and the Kara seas and Iphinopsis inflata (Friele, 1879) from the Pacific part of the Arctic Ocean. Lectotype for Admete contabulata is here designated.
Family Cyclophoridae in Vietnam (Gastropoda: Cyclophoroidea): the genus Cyclophorus Montfort, 1810
Authors: Do Duc Sang , Do Van Nhuong
Published: September 2021

Vietnam with its limestone ranges that are concentrated mainly in northern, north-central and southern parts, and many different limestone islands running along the coastline, has a phylogenetically-diverse land snails fauna dominated by endemic species. The genus Cyclophorus (Cyclophoridae) in Vietnam is studied. Sixty species and subspecies from various habitats of limestone areas throughout Vietnam are confirmed and recorded. New species and subspecies, Cyclophorus implicatus kanhoensis ssp. nov., from Northwestern Vietnam, and Cyclophorus tamdaoensis sp. nov., from Northern Vietnam are described and discussed. In this paper, the Cyclophorus courbeti var. leucostoma Dautzenberg et Fischer, 1905, is elevated to subspecies.
First finding of a widely distributed Antarctic chiton species (Mollusca: Polyplacophora) in the North Pacific
Authors: Sirenko B. I.
Published: September 2021

For the first time, the widely spread Antarctic species Leptochiton antarcticus was found at the Emperor Seamounts in the North Pacific Ocean. In spite of a large distance between the Emperor Seamounts and Antarctica, the found specimen have very similar shell, girdle, radula and gill features to the type material. I propose that L. antarcticus spread to the North Pacific from the Antarctic via a deep-water current near the ocean floor, and perhaps it inhabits the slopes of islands and continents from the South Ocean to the Emperor Seamounts.
Correction of two homonyms and an original spelling of Thach [2018]
Authors: Páll-Gergely Barna
Published: September 2021

Two substitution names are proposed for primary homonyms introduced for land snail of the family Camaenidae in Thach [2018].
Literature review: implementation of Musharakah Mutanaqisah partnership over the world
Authors:   Magister Akuntansi, FEB Universitas Sebelas Maret, Juliyanti Wiwin , Wibowo Yohanes K. ,   Magister Akuntansi, FEB Universitas Sebelas Maret
Published: September 2021

Abstract Purpose: This study aimed to determine the implementation of Musharakah Mutanaqisah. Research methodology: This research method was a literature study with data obtained from previous research and theories relevant to the research topic. Results: The research results show that Musharakah Mutanaqisah in the two countries still needs to be encouraged for its development, because Murabahah still dominates it, Ba'i, ijarah and others financing, the results of the study also concluded that the implementation of Musharakah Mutanaqisah is equally an alternative in property financing in Malaysia, and homeownership loans in Indonesia. Limitations: This research only examined the application of MMP in Southeast Asia Contribution: Findings contribute that internationally, accounting for Musharakah Mutanaqisah refers to IFRS and FAS. In Malaysia, the regulations governing the accounting for Musharakah Mutanaqisah are regulated in the Malaysian Financial Reporting Standards (MFRS). ). In Indonesia, the regulations governing the accounting for Musharakah Mutanaqisah are not yet available, so they are still regulated in PSAK No. 106 (Musharakah Akad). Keywords: Musharakah Mutanaqisah partnership, Islamic bank, Sharia accounting
Meneropong Work-Life Balance selama Covid-19: Studi Kasus Aparatur Sipil Negara di Jakarta Pusat
Authors:   Jurusan Manajemen, Universitas Bina Nusantara, Jakarta Barat, Tongam Edwin Gideon , Linardy Muhammad Fazry Eggy ,   Jurusan Manajemen, Universitas Bina Nusantara, Jakarta Barat, Saputra Muhammad Kurniawan ,   Jurusan Manajemen, Universitas Bina Nusantara, Jakarta Barat, Saputra Nopriadi ,   Jurusan Manajemen, Universitas Bina Nusantara, Jakarta Barat
Published: September 2021

Abstract Purpose: The purpose of this study is to describe and analyze: (1) How the Work-Life Balance, Flexible Working Arrangement, and Telework Ability of the State Civil Apparatus (ASN) in Central Jakarta during the COVID-19 pandemic (2) Measure the effect of Flexible Working Arrangement and Telework Ability on Work-Life Balance (3) Effect of Flexible Working Arrangement on Telework Ability of ASN in Central Jakarta during the COVID-19 pandemic. Research Methodology: The method in this research is quantitative. The research instrument used an online questionnaire distributed to ASN in Central Jakarta in a Google Form. The data analysis method used is a descriptive analysis of variables and respondents, the respondents in this study work in government offices located in the Central Jakarta area. The test used in this research is the Statistical Test and Hypothesis Testing Using the SPSS 25 Application. The sampling technique used is non-probability sampling and uses a convenience and snowball approach with the Krejcie formula. Results: The results of this study indicate that the application of Flexible Working Arrangement and Telework Ability of ASN has a positive effect on their Work-Life Balance. Limitation: The limitation of the research is in the pandemic conditions, which limit researchers from conducting offline research. Contribution: It is hoped that this research can be useful for Government Agencies in the Central Jakarta area as well as a reference for further research on Flexible Working Arrangements, Telework Ability, and Work-Life Balance.
Penerapan Digital Marketing sebagai Strategi Pengembangan Usaha Ternak Tikus Putih
Authors:   Fakultas Informatika dan Komputer, Institut Teknologi dan Bisnis STIKOM Bali, Denpasar, Ahmadi Candra , Hermawan Dadang ,   Fakultas Informatika dan Komputer, Institut Teknologi dan Bisnis STIKOM Bali, Denpasar, N L P Srinadi ,   Fakultas Informatika dan Komputer, Institut Teknologi dan Bisnis STIKOM Bali, Denpasar, T M Kusuma ,   Fakultas Informatika dan Komputer, Institut Teknologi dan Bisnis STIKOM Bali, Denpasar
Published: September 2021

Abstract Purpose: This community service aimed to provide counseling on utilizing technological advances at the Bikul Bali White Rat Farm Business for marketing purposes. Method: Thee methods applied were accompaniment counseling on technological advances, lectures, and direct practice by applying digital marketing to reach and get new consumers. Result: The Partner understands the importance of implementing digital marketing and is confident in promoting their white rats through the marketplace even though there are extra costs for promotion. Conclusion: This community service activity has a positive impact as an additional knowledge of partners in understanding digital marketing. The partner now takes advantage of the availability of the marketplace as a medium for selling as a form of application of digital marketing and starting to reach new potential consumers who are accustomed to using marketplaces in shopping.
Mathematical Modeling Of Magnetic Scaffolds For Targeted Drug Delivery And Bone Repair
Authors: Lodi Matteo Bruno , Fanti Alessandro , Vargiu Andrea , Bozzi Maurizio , Mazzarella Giuseppe
Published: September 2021

Magnetic bone substitutes are multifunctional nanocomposite biomaterials designed to serve as an in situ attraction platform for magnetic carriers of growth factors. The morphological and functional properties of these biomaterials were characterized so far, but very little is known on the treatment dynamics, and the latter cannot be designed from an engineering point of view. For the first time, this work deals with the mathematical modeling of the use of magnetic scaffolds and functionalized nanoparticles to evaluate the enhancement of osteogenesis and bone repair. The non-linear magnetization of the scaffolds is considered to simulate the attraction and transport of magnetic nanoparticles. Different biomaterials and drug carriers from the literature are analyzed. The drug release via RF-heating is modeled considering the multiphysics nature of the phenomena. The physiological process of bone healing is reproduced using nine non-linear equations. The influence of the delivered growth factor on osteogenesis is assessed and quantified in silico, while compared to numerical simulations of intravenous injection of growth factor and to its release from the biomaterial. The exploitation of magnetic carriers of biomolecules with magnetic scaffolds allows to produce a more homogeneous and uniform distribution of mature bone, overcoming the limitation of traditional drug delivery techniques.
Resiliensi Akademik dengan Kepuasan Belajar Online pada Mahasiswa
Authors: Afriyeni Nelia , Rahayuningsih Tri , Erwin Erwin
Published: September 2021

Pandemi Covid-19 berdampak pada mahasiswa belajar dari rumah secara online (daring) selama masa karantina dapat menurunkan motivasi mahasiswa karena kepuasan belajar menjadi terganggu akibat literasi digital yang rendah dan penyesuaian belajar saat di rumah. Masalah-masalah psikologis juga timbul, sehingga dibutuhkan ketahanan psikologis menghadapi situasi yang tidak menyenangkan dan kemampuan beradaptasi, yaitu resiliensi akademik untuk menjadi faktor kepuasan belajar online pada mahasiswa selama pandemi Covid-19. Tujuan penelitian ini adalah untuk mengetahui hubungan resiliensi akademik dengan kepuasan belajar online pada mahasiswa selama proses pembelajaran jarak jauh. Metode penelitian dibagi dalam dua tahap yakni secara kualitatif melalui 19 buah pertanyaan terbuka kepada 11 orang mahasiswa untuk merumuskan konstruk pengukuran dan secara kuantitatif menguji validitas aitem pengukuran tersebut dengan program SPSS pada 116 mahasiswa melalui survei google form. Dari hasil uji korelasi pearson sebesar 0.473 dan P<0.000 , maka diperoleh hubungan antara resiliensi akademik dengan kepuasan belajar online, sehingga kesimpulan penelitian ini yaitu hipotesa diterima. Hasil penelitian ini bermanfaat bagi mahasiswa untuk meningkatkan faktor-faktor kepuasan selama belajar dari rumah, salah satunya melalui faktor resiliensi, yang akan dibahas pada tulisan ini.
(Re)significando a educação física escolar no ensino médio: a partir do planejamento de ensino de jogos populares
Authors: Silva Camila Rubira
Published: September 2021

OBJETIVO: Apresentar um relato de experiência do planejamento e desenvolvimento colaborativo de uma proposta pedagógica para o ensino de Educação Física (EF) no Ensino Médio (EM), por meio da abordagem de Jogos populares, visando fomentar discussões sobre a importância do ato de planejar o ensino para o desenvolvimento integral dos estudantes, como um mecanismo de legitimação da EF enquanto área do conhecimento no currículo escolar. MÉTODOS: A proposta foi planejada de forma colaborativa com 21 estudantes do 2° ano do EM. No desenvolvimento da proposta oportunizamos o ensino de Jogos populares, por meio de três momentos: leitura de textos, experimentação de jogos e, conversas sobre a aula. RESULTADOS: Evidenciamos que a organização desses momentos tenha contribuído para formação integral dos estudantes, no diz respeito a aquisição de saberes conceituais relativos às diferentes culturas existentes no país; a construção de saberes corporais experimentados na prática dos jogos e, saberes atitudinais referentes ao prazer em experienciar os jogos, a criatividade e autonomia ao criar regras pensando na cooperação e cuidado com os colegas. CONCLUSÃO: Consideramos ser necessário que o professor reconheça no ato de planejar o ensino, o potencial pedagógico para (re)significar a sua prática, de modo a contribuir para formação dos estudantes, consequentemente, para que a EF seja valorizada no contexto escolar.
Hybrid Parallel Image Processing Algorithm for Binary Images with Image Thinning Technique
Authors: Sathesh A , Babikir Adam Edriss Eisa
Published: September 2021

Image thinning is the most essential pre-processing technique that plays major role in image processing applications such as image analysis and pattern recognition. It is a process that reduces a thick binary image into thin skeleton. In the present paper we have used hybrid parallel thinning algorithm to obtain the skeleton of the binary image. The result skeleton contains one pixel width which preserves the topological properties and retains the connectivity.
Educación, política y escuela desde Freire y las pedagogías críticas.
Authors: Chaustre Avendaño Alvaro
Published: September 2021

El siguiente texto analiza el carácter político de la educación y la escuela desde reflexiones teóricas elaboradas por algunos representantes de las pedagogías críticas, entre ellos Paulo Freire. En él los lectores y las lectoras encontrarán elementos e ideas que ponen de manifiesto la necesidad de identificar la educación como un hecho histórico, cultural y político, la escuela como un espacio de lo público, y los maestros y maestras como reproductores de las falencias de la escuela o como innovadores y transformadores de las prácticas tradicionales antidemocráticas. A partir de la realidad colombiana y con base en el análisis de una serie de experiencia  pedagógicas, adelantadas en instituciones de los EE.UU. y en la ciudad de Bogotá, se insiste en la necesidad de avanzar, en los ámbitos educativos y escolares, en el proceso de formación en cultura política como condición para la dignificación de los seres humanos
Calidad educativa,justicia y bienestar
Authors: Arana Sáenz Lmelda
Published: September 2021

La calidad de la educación se torna relevante en el momento actual en que nos encontramos a mitad de camino de la fecha meta del Marco de Acción de DAKAR y de los Objetivos de Desarrollo del Milenio - ODM, que han fijado el año 2015 para el logro de la universalización del acceso a la escolaridad básica de la población infantil del mundo, logrado lo cual se podría pasar a establecer metas relacionadas con la calidad educativa.En el ámbito colombiano, país donde según las estadísticas oficiales estamos cerca del cumplimiento de tales metas, las políticas públicas, tanto del orden nacional como de la ciudad capital, han postulado como programas para los años siguientes, el logro de la calidad educativa. Lo cual se proyecta también en un país que cuenta con una legislación avanzada que da espacios a la formulación y aplicación de transformaciones pedagógicas para el logro de esa calidad. La ciudad capital donde el postulado de la calidad se conjuga con principios como la inclusión social y el respeto de los derechos, da pie a que la población se entusiasme con la propuesta y se sume a laproyección de iniciativas hacia la calidad educativa para vivir mejor en la ciudad, entusiasmo que ha estimulado la escritura de este artículo.
Колко редки са редките онкологични болести?
Authors: Консулова Ася , Йорданов Ангел , Ел Шемери Самър , Калчев Калин , Стоева Таня , Чаушева Росица , Данчева Живка , Спасов Христо
Published: September 2021

Развитието на технологиите, молекулярната генетика и фармакологичната индустрия доведе до подобряване на лечебно-диагностичния процес в медицината. В онкологията през последните десетилетия много фатални в миналото диагнози се превърнаха в излечими или хронично протичащи болести. Това, обаче, не винаги е така при редките онкологични болести. Въпреки разминаването в различните определения за редки онкологични болести, епидемиологични данни сочат, че взети заедно, те съставляват над 20% от всички онкологични диагнози.

Обобщението на данните за тези редки нозологии в онкологията е ключово за тяхната по-добра диагноза, лечение. Известно е и, че тяхната регистрация е субоптимална, особено в страните от Източна Европа. Водещите проблеми в онкологията са свързани с диагнозата и откриването на туморите, за разлика от другите редки неонкологични болести и това влошава много клинични параметри. Вече има данни за удължаване на преживяемостта и подобряване на много клинични резултати при лечение и проследяване в специализирани центрове, поради което експертното поведение в специализирани центрове е силно препоръчително. Вече е изграден и концептуален модел за функциониращ специализиран център, към който да се стремят всички държави.
THE CLINICAL-BIOLOGICAL EFFECTS OF PERIODONTAL CURETTAGE IN DENTAL PRACTICE
Authors:   ,,Dimitrie Cantemir’’ University, Medicine Faculty, Targu-Mures, Romania, FEIER Ramona , RAFTU Gheorghe ,   Ovidius University of Constanta, Faculty of Medicine and Pharmacy, Constanta, Romania, MARIS Marius ,   Titu Maiorescu University, Dental Medicine Faculty, Bucharest, Romania, CARAIANE Aureliana ,   Ovidius University of Constanta, Faculty of Medicine and Pharmacy, Constanta, Romania
Published: September 2021

Periodontal curettage is one of the basic procedures in marginal periodontium surgery. It is performed during the initial treatment phase of periodontal diseases, which occurs after emergency treatment (when appropriate) of acute complications of chronic marginal periodontal diseases. Periodontal curettage may be divided according to the area where it is performed in: gingival periodontal curettage, subgingival periodontal curettage. Gingival periodontal curettage is performed in the gingival groove and in the false gingival pockets, without usually exceeding the junctional epithelium insertion area. The main objective of subgingival periodontal curettage is to restore gingival health by removing from the root surface the factors that can cause gingival inflammation. The personal study was performed on two groups which included 82 patients. When analyzing the results, we relied on the justified assumption of the study that each case in the large framework of periodontal diseases represents a particular clinical-radiological and etiological reality as concerns its frequency and evolution (especially in terms of complications). The social origin and the cultural background play a very important role in the development of this relationship, which is at its best when both the doctor and the patient are closer from these points of view.
PENGARUH EDUKASI EARLY WARNING SYSTEM (EWS) TERHADAP RESPON TIME PERAWAT DI IGD BRSUD KABUPATEN TABANAN
Authors: Budiari Ni Made , Susila I Made Dwie Pradnya , Arisudhana Gede Arya Bagus
Published: September 2021

Emergency patient care is a service that requires immediate service, namely fast, precise, and accurate to prevent death or disability. One of the indicators of service quality is in the form of response time, which is a process indicator to achieve the outcome indicator, namely survival. To achieve a fast response time, a systematic approach system is needed in dealing with patients who experience emergencies, one of which is by using the Early Warning System (EWS). This study aims to determine the effect of early warning system education on the response time of nurses in Emergency Room Tabanan Hospital. This study used an experimental method with a pre-experimental design (one-group pre-test-posttest design) involving 39 samples selected by total sampling technique. Data collection in providing EWS education is in the form of modules, and the research material is in the form of a clock used to measure the response time. Data analysis uses a computerized system with univariate and bivariate analysis. This study showed that the response time for nurses before the early warning system education was fast, namely 15 (39.5%). Most of the nurses' response time after the early warning system education was 26 (66.7%). The results of this study can be concluded that there is an effect of early warning system nurse education on the response time of nurses with a significance value (p) of 0.000.