bluuebunny/crossref_metadata_2025 huggingface dataset:
Going Vague: Ambiguity and Avoidance in Online Political Messaging
Authors: Chapp Christopher , Roback Paul , Johnson-Tesch Kendra , Rossing Adrian , Werner Jack
Published: August 2018

Researchers have long investigated the conditions that promote the unambiguous communication of issues in political campaigns; however, previous research has been largely theoretic or has only tested ambiguous communication on a limited range of issues. We address these gaps, making three principal contributions. First, we provide an extensive empirical test of ambiguous communication, scoring every issue addressed on website “issues pages” from House candidates in 2014. Second, we accomplish this by using a supervised learning content analysis procedure that allows us to score a large volume of text based on a smaller subset of hand-coded text. This allows us to not only examine whether candidates comment on an issue but also the clarity of their message. Third, this article provides empirical support for how candidates’ communication strategies are shaped not only by the candidates’ personal characteristics but also the characteristics of the district. We find that district heterogeneity is an important predictor of ambiguous communication. Evidence also indicates that issue ownership and ideological extremity play a decisive role in the decision to “go vague.”
Sovereignty and Submission: Luther’s Political Theology and the Violence of Christian Metaphysics
Authors: Mjaaland Marius Timmann
Published: August 2018

The classical controversy between Carl Schmitt and Eric Peterson goes directly to the heart of the matter: What is ‘political theology’ about? Is it a descriptive or normative endeavour, oriented towards history or political influence on contemporary issues? This article explores these questions with reference to Protestant theology, in particular the writings of Martin Luther.

Protestant theology has often emphasised the basic difference between the spiritual and political spheres, but I question the validity of this distinction with respect to Luther’s theology. When Luther enters the political scene, an apocalyptic understanding of friend and enemy tends to dominate his thinking. Furthermore, I discuss whether this is compatible with his metaphysical understanding of the ‘hidden God’ in his majesty, and hence, whether a metaphysical violence is deeply embedded in Luther’s theology, possibly even his understanding of ‘justification by faith’. Finally, I suggest a reconsideration of Luther’s political theology based on the questions raised by Schmitt and Peterson.
A fault diagnosis method for rolling element bearing (REB) based on reducing REB foundation vibration and noise-assisted vibration signal analysis
Authors: Wang Heng-di , Deng Si-er , Yang Jian-xi , Liao Hui
Published: August 2018

Owing to the problem of the incipient fault characteristics being difficult to be extracted from the raw vibration signal of rolling element bearing, based on the empirical mode decomposition and kurtosis criteria, a fault diagnosis method for rolling element bearing is proposed by reducing rolling element bearing foundation vibration and noise-assisted vibration signal analysis. Firstly, rolling element bearing vibration signal is decomposed into a set of intrinsic mode functions using empirical mode decomposition and the intrinsic mode function component with the maximal kurtosis value is selected. Afterwards, zero mean normalization is applied to the selected intrinsic mode function component, and then the intrinsic mode function’s foundation vibration components within [Formula: see text] are removed to minimize the interference. In order to eliminate interruption and intermittency after removal of the foundation vibration components, white noise is added to the newly generated signal. The noise-added signal is decomposed via empirical mode decomposition, and later on, IMF1 with the highest frequency band is selected and demodulated using envelope analysis. The resulting envelope spectrum can show more significant fault pulse characteristics, which are highly helpful to diagnose the rolling element bearing incipient faults. The proposed method in this paper was applied to the fault diagnosis for low noise REB 6203 and the testing results showed that the method could identify the rolling element bearing incipient faults accurately and quickly.
A load-balancing-oriented symmetrical uneven layout design for thrust system in tunneling machines under composite ground
Authors: Deng Kongshu , Yin Zhurong , Meng Bangliang , Xiang Cong
Published: August 2018

Mechanized tunneling is characterized by high automation, efficiency, safety, and environment-friendly during tunnel construction progress. Studies to improve the force transmission performance of the thrust system playing an important role among all sub-systems in shield machine have been conducted recently. In this paper, a new nonequidistant arrangement with load-balancing-oriented ability has been proposed under complex ground. Firstly, the required mechanical functions are derived from the force transmission ellipse model. Secondly, the symmetrical uneven thrust system model has been set up to solve the mechanical functions. Then, all characteristics for the symmetrical shape driving system model have been investigated in detail. Finally, applying the solving model to the thrust system of a shield machine with a diameter 6.28 m, which has been used to construct some tunnels, the comparison of force transmission between the designed uneven thrust system and the even system manifests that the performance for nonuniform driving system is more uniform than the latter. The results also proved that nonequidistant thrust system with the better transmissibility in force can be preferred under some mixed ground.
‘Pinel of Istanbul’: Dr Luigi Mongeri (1815–82) and the birth of modern psychiatry in the Ottoman Empire
Authors: Artvinli Fatih
Published: August 2018

Italian physician/alienist Dr Luigi Mongeri (1815–82), who graduated from the School of Medicine in Pavia and worked as chief physician at Süleymaniye and Toptaşı Lunatic Asylums, introduced important reforms that shaped modern psychiatry in the Ottoman Empire. Because of his projects and practices he was likened to Philippe Pinel (1745–1826), and was called the ‘Pinel of Istanbul’ or ‘Pinel of the Turks’. This article aims to examine the birth of modern psychiatry in the Ottoman Empire, through the biography of Luigi Mongeri and his writings on insanity.
Chironomid-inferred Holocene temperature reconstruction in Basa de la Mora Lake (Central Pyrenees)
Authors: Tarrats Pol , Heiri Oliver , Valero-Garcés Blas , Cañedo-Argüelles Miguel , Prat Narcís , Rieradevall Maria , González-Sampériz Penélope
Published: August 2018

We present the first Holocene chironomid-based summer temperature reconstruction for the Iberian Peninsula. A sequence from the shallow mountain lake Basa de la Mora (1914 m a.s.l., Central Pyrenees) was analysed and the reconstruction was performed by means of a merged Norwegian–Swiss chironomid calibration dataset. The presence of a multiproxy study conducted in the same lake, as well as other available regional temperature estimations, allowed the comparison of our results with distinct local and regional records in order to disentangle different temperature and hydrological and seasonal patterns throughout the Holocene. The sampling resolution does not allow analysing rapid climatic oscillations, but provides insights into general Holocene trends. Overall, we found increasing temperatures at the onset of the Holocene, reaching the highest values during the Holocene Climatic Optimum (in our record ca. 7800 cal. yr BP). High temperatures were observed until ca. 6000 yr BP, when a decline of ca. 1.5ºC was inferred and the lowest temperature values throughout the sequence were reconstructed during the period 4200–2000 cal. yr BP coinciding with the first part of the late Holocene. Finally, an increasing trend in temperature values characterized the last two millennia, although we interpret this reconstructed temperature rise with caution as distinguishing between climatic and anthropogenic influences on the chironomid record in this youngest section of the Holocene is challenging.
Zooarchaeological evidence that the brown mussel (Perna perna) is a bioinvader of coastal Brazil
Authors: Silva Edson P , Souza Rosa CCL , Lima Tania A , Fernandes Flávio C , Macario Kita D , Netto Bruna M , Alves Eduardo Q , Carvalho Carla , Aguilera Orangel , Duarte Michelle R
Published: August 2018

Interactions between invader species and the local biota may lead to disequilibria in regional ecosystems. For such reason, the cultivation of nonnative species may be prohibited in specific regions, as a means of protecting native species. On the other hand, the question of whether a species is a bioinvader or not may not be straightforward. This is the case of the mollusc Perna perna, presently naturalized and widely distributed along Brazilian coast, from the Bay of Vitória, in the state of Espírito Santo (ES), to the state of Rio Grande do Sul (RS). Following previous works that explored the hypothesis that P. perna invaded the coast of Brazil at the colonial period, attached to slave ships, we discuss zooarchaeological data, radiocarbon dating, and molecular genetics analyses. Out of the 578 archeological shellmounds investigated, 542 (93.8%) had no records of P. perna. From the radiocarbon dating results, it is possible to infer that the presence of the two P. perna specimens from the Saquarema shellmound, in Rio de Janeiro, as well as the other shells from the top layer, is likely related to a recent occupation of the site in the colonial period, with a great probability of being from the XVII or XVIII centuries. Data on genetic population structure of P. perna along the Brazilian coast showed higher genetic identities between the African and the Brazilian populations than among the Brazilian populations, while haplotypic diversity shows a pattern which relates to trade routes of slaves (XVII and XVIII centuries) between Africa and Brazil. These data reinforce the argument that the appearance of P. perna along the Brazilian coast is due to invasion during historical time.
Late-Holocene cliff-top blowout activation and evolution in the Cooloola Sand Mass, south-east Queensland, Australia
Authors: Ellerton Daniel , Rittenour Tammy , Miot da Silva Graziela , Gontz Allen , Shulmeister James , Hesp Patrick , Santini Talitha C , Welsh Kevin J
Published: August 2018

Cliff-top dunes are a locally important geomorphic features of sedimentary coasts. They are traditionally interpreted as being sourced by (or with) sand derived from the beach below the cliff. This paper presents the results of a stratigraphic and geochronological study of Carlo Sand Blow, a coastal blowout that has developed on top of a high sandy cliff in the Cooloola Sand Mass, south-east Queensland. We use a combination of sedimentological, pedological and geophysical techniques along with optically stimulated luminescence dating to determine the depositional history and evolution of the blowout. We demonstrate that the blowout is dominantly nourished by sand eroded from its floor rather than the adjacent beach. The original dune surface dates to the first half of the last glacial period (c. 40–70 ka) and this dune was deflated in the late-Holocene. Dune activity is directly associated with cliff undercutting because of coastal retreat in the late-Holocene, but coastal erosion on its own is not capable of maintaining aeolian activity. Blowout activity occurred between 2.6 and 2.3 ka and again at 0.3 ka with aeolian sand burying palaeosols. Both soil surfaces contained charcoal and tree stumps in growth position and our study suggests that fire is the immediate trigger for blowout reactivation. It is likely that these fires were anthropogenic in origin, because the site is somewhat protected from natural fire and the ages coincide with intensification of human use of coastal sites in the area.
The Influence Factors Towards Mobile Advertising Message Content on Consumer Purchase Intention
Authors: Hashim Nor Hazlina , Normalini  , Sajali Norhazlina
Published: August 2018

The purpose of this research is to study consumer attitude towards mobile advertising in Malaysia, and whether this attitude results in the intention to purchase the products or services advertised. This article reports on the results, based on factors such as entertainment, informativeness, irritation and credibility, which the research framework derives from Ducoffe (1996, Advertising value and advertising on the Web, Journal of Advertising Research, 36(5), 21–35) and Mackenzie (1989, An empirical examination of the structural antecedents of attitude toward the ad in an advertising pretesting context, Journal of Marketing, 53(4), 48–65). Attitudes towards behaviours, and subjective norms, based on the research by Ajzen (1991, The theory of planned behaviour, Organizational Behaviour & Human Decision Processes, 50(2), 179–211), are included in understanding consumer intention. A survey is conducted on 150 respondents, and the partial least squares analysis is used to determine the antecedents of mobile advertising that lead to consumer acceptance of mobile advertising, and the resulting intention to purchase. Results show that the advertising message content has the largest impact on attitude in advertising that is done via mobile phone. Attitudes towards mobile advertising are linked to the intention to purchase the product or services advertised. The main implication of the study shows that marketing managers should focus their marketing communication on mobile advertising, and increasing the attractiveness of this form of advertising, so as to reflect consumers’ intention to purchase. This study opens a new channel of communication for multiple unexamined matters concerning the mobile advertising industry. Based on the results, a number of recommendations are proposed and suggestions for future studies are made.
Review of Cyclin-Dependent Kinase 4/6 Inhibitors for the Treatment of Hormone Receptor–Positive Advanced Breast Cancer
Authors: Hecht Keith A. , Selby Christopher
Published: August 2018

Objective: To evaluate the existing literature regarding the use of cyclin-dependent kinase (CDK) 4/6 inhibitors in the treatment of hormone receptor–positive advanced breast cancer (ABC). Data Sources: A search of the medical literature was performed using PubMed (2014 to June 2018). Search terms included cyclin-dependent kinase, CDK, breast cancer, palbociclib, ribociclib, abemaciclib, PD0332991, LEE011, and LY2835219. Clinicaltrials.gov was also searched. Study Selection and Data Extraction: Trials with clinical efficacy outcomes evaluating CDK 4/6 inhibitors in the treatment of advanced hormone-positive breast cancer were considered. Data Synthesis: Palbociclib, abemaciclib, and ribociclib each demonstrated significant benefit when combined with an aromatase inhibitor, the benefit to patients was similar for each, with an improvement of 42% to 51% in median progression-free survival (PFS). In combination with fulvestrant, CDK 4/6 inhibitors used for the treatment of hormone receptor–positive ABC resulted in a 43% to 58% improvement in median PFS versus fulvestrant alone. CDK inhibitors are relatively well tolerated; however, discontinuation as a result of adverse effects was highest with abemaciclib. Relevance to Patient Care and Clinical Practice: This review considers the use of the 3 commercially available CDK 4/6 inhibitors for treatment of hormone receptor–positive breast cancer, including data on each of the 3 agents in newly advanced and treatment refractory disease. Conclusions: The CDK inhibitors should be used in combination with endocrine therapies for the treatment of ABC. Efficacy of the 3 agents is similar. Selection within the class should include consideration of adverse effects and drug interactions.
Examining the Therapeutic Processes Associated With Conservative Christian Parental Acceptance of Their Son or Daughter’s Lesbian, Gay, or Bisexual Orientation
Authors: Cavallo Francis J. , Bradley Christopher
Published: August 2018

Parents with strong conservative Christian religious beliefs may view their son or daughter’s lesbian, gay, or bisexual (LGB) orientation disclosure as a family crisis, and as a result, may seek out support and direction from a Licensed Christian Mental Health Practitioner (LCMHP). The counsel that the LCMHP provides, and a parent’s subsequent responses to his or her disclosing son or daughter, can have substantive and enduring positive or negative impacts on the youth’s physical and mental health. While it is known that parents can become more accepting of their LGB-oriented son or daughter, the processes by which greater acceptance occurs for conservative Christian parents has yet to be fully examined. The present study employed an interpretative phenomenological analysis research methodology to garner a greater understanding of the conservative Christian parental acceptance phenomena that occurs within the context of a therapeutic engagement between parents and an LCMHP. Providing a greater understanding of the processes and meanings associated with this phenomenon will provide LCMHPs with information that could assist them in helping conservative Christian parents to better navigate their relationship with their LGB-oriented son or daughter.
“Subversive, Unannounced Non-Compliance”: A Pacifist-Soldier’s Poetic (Auto) Ethnography of Experiences in the Israeli Defense Forces
Authors: Hanauer David I.
Published: August 2018

The current article presents the experiences of a pacifist-soldier who was drafted into the Israel Defense Forces in the 1980s. Using a poetic (auto) ethnographic mode of research, this article explores the ways in an individual with self-professed pacifist orientations responds and contends with realities of being drafted into an army and a situation which he ethically disagrees with. The poem follows the events and emotional responses to different aspects of being in the army and the strategic way in which agency was enacted under very restrictive social circumstances termed by the participant as “subversive, unannounced non-compliance.” The current poetic (auto) ethnography aims to contribute to the literature of soldier experiences and explicate one individual’s response to being drafted against his will into an army he did not identify or agree with.
Methodology as a Pedagogy of Vulnerability: Doctoral Research With/in/From the Borderlands
Authors: Rodricks Dirk J.
Published: August 2018

In this article, I trace the ways in which my doctoral thesis methodology became a “pedagogy of vulnerability.” Using two “stop moments,” I describe the emergent “openings” that not only helped shape and shift the direction of my research, but also allowed me to be shaped by it. In being willing to labor, risk, and learn in and through the methodological choices made and especially with/in/from the borderlands, I demonstrate how one might think, work through, and play with the many possibilities that could interrupt the normative ways of “doing” research.
Towering Invisibilities: A Cultural-Theoretical Reading of the Eiffel Tower and the One World Trade Center
Authors: Steiner Henriette , Veel Kristin
Published: August 2018

This article explores forms of visuality in architecture in which symbolic and functional values interlink by considering two visually striking and deeply symbolic landmarks that tower over their respective cities at the same time as their impact is related to the invisible wireless communication they facilitate. It contrasts cultural-theoretical responses to the Eiffel Tower (1889) with readings of the One World Trade Center (2014). In this way, we contour a theoretical framework to grasp the compounded forms of signification these towers embody and address the latent and invisible signification at work by turning to the work of the French philosophers Roland Barthes (1915-1980) and Jean-Francois Lyotard (1924-1998).
Latent Profile Analysis of Alcohol Consumption and Sexual Attitudes Among College Women: Associations With Sexual Victimization Risk
Authors: Yeater Elizabeth A. , Witkiewitz Katie , López Gabriela , Ross Ryan S. , Vitek Kristen , Bryan Angela
Published: August 2018

This study used latent profile analysis (LPA) to identify at-risk profiles of college freshman women ( n = 481) using self-reports of alcohol consumption and sociosexuality. Analyses resulted in three profiles labeled low alcohol use–low sociosexuality, high alcohol use–medium sociosexuality, and high alcohol use–high sociosexuality. Baseline victimization predicted latent profile membership. More severely victimized women were more likely to be in the high alcohol–high sociosexuality profile than the high alcohol–medium sociosexuality and low alcohol–low sociosexuality profiles. At follow-up, the high alcohol–high sociosexuality profile had higher mean levels of victimization severity, relative to those in the high alcohol–medium sociosexuality and low alcohol–low sociosexuality profiles.
Reducing Heavy Episodic Drinking, Incapacitation, and Alcohol-Induced Blackouts: Secondary Outcomes of a Web-Based Combined Alcohol Use and Sexual Assault Risk Reduction Intervention
Authors: Gilmore Amanda K. , Bountress Kaitlin E. , Selmanoff Mollie , George William H.
Published: August 2018

Heavy episodic drinking, alcohol-induced blackouts, and incapacitation are associated with sexual assault among college women. Therefore, reducing heavy episodic drinking, alcohol-induced blackouts, and incapacitation among college women may reduce sexual assault victimization risk. The current study examined the indirect effect of a combined alcohol use and sexual assault risk reduction program on sexual assault severity through heavy episodic drinking, alcohol-induced blackouts, and incapacitation ( n = 264). An alcohol use reduction program, sexual assault risk reduction program, and combined alcohol use and sexual assault risk reduction program were compared with a control condition. The sexual assault risk reduction content reduced alcohol-induced blackouts and incapacitation, and the combined alcohol use and sexual assault risk reduction program reduced alcohol-induced blackouts. Only incapacitation was associated with reduced sexual assault severity at follow-up. Reducing incapacitation and alcohol-induced blackouts is possible with a brief, web-based intervention, and reducing incapacitation may be one viable strategy within larger sexual assault prevention programming efforts.
Sequential Experimental Design for Optimal Structural Intervention in Gene Regulatory Networks Based on the Mean Objective Cost of Uncertainty
Authors: Imani Mahdi , Dehghannasiri Roozbeh , Braga-Neto Ulisses M , Dougherty Edward R
Published: August 2018

Scientists are attempting to use models of ever-increasing complexity, especially in medicine, where gene-based diseases such as cancer require better modeling of cell regulation. Complex models suffer from uncertainty and experiments are needed to reduce this uncertainty. Because experiments can be costly and time-consuming, it is desirable to determine experiments providing the most useful information. If a sequence of experiments is to be performed, experimental design is needed to determine the order. A classical approach is to maximally reduce the overall uncertainty in the model, meaning maximal entropy reduction. A recently proposed method takes into account both model uncertainty and the translational objective, for instance, optimal structural intervention in gene regulatory networks, where the aim is to alter the regulatory logic to maximally reduce the long-run likelihood of being in a cancerous state. The mean objective cost of uncertainty (MOCU) quantifies uncertainty based on the degree to which model uncertainty affects the objective. Experimental design involves choosing the experiment that yields the greatest reduction in MOCU. This article introduces finite-horizon dynamic programming for MOCU-based sequential experimental design and compares it with the greedy approach, which selects one experiment at a time without consideration of the full horizon of experiments. A salient aspect of the article is that it demonstrates the advantage of MOCU-based design over the widely used entropy-based design for both greedy and dynamic programming strategies and investigates the effect of model conditions on the comparative performances.
Cooperativeness – A necessary trait for interpreters? A study on temperament and character dimensions of experts in different fields
Authors: Hiltunen Sinikka , Mäntyranta Heli , Määttänen Ilmari
Published: August 2018

Aims and Objectives:

The aim of the present study was to investigate whether particular temperament and personality traits are more characteristic to interpreters’ expert performance than to expert performance in other fields.

Design:

To these ends, the Temperament and Character Inventory by Cloninger et al. (1994) and the distractibility scale of the Revised Dimensions of Temperament Survey by Windle (1992) were used.

Data and Analyses:

The data was gathered from two groups of interpreters (simultaneous and consecutive) and was compared to one group of foreign language teachers and one of non-linguistic experts from different fields of society. The group size varied between 20 and 23 participants each. The analyses were carried out with multivariate analysis of variance, supplemented with Bonferroni corrected contrasts.

Findings:

The results seem to indicate that temperament and character traits may have different impacts on different expert groups. In this study, in comparison to the control groups of foreign language teachers and non-linguistic experts, high cooperativeness was found to be more characteristic to simultaneous and consecutive interpreters. Cooperativeness also appears to be valued by recruiters and trainers of interpreters, for instance.

Originality:

The study was the first one comparing interpreters’ temperament and character dimensions with those of other expert groups, such as foreign language teachers and non-linguistic experts.

Significance and Limitations:

Among the different temperament and personality traits, at least cooperativeness seems to have a connection to the abilities and skills needed in the profession of an interpreter. More research, however, is needed to reveal possible connections of various temperament and personality traits with expertise in different fields. In this particular case, additional studies could show whether individuals with high cooperativeness become more easily interested in such professions as interpreting, or whether the high cooperativeness is a result of more experience and expertise in interpreting.
Technical Aspects of Using the AngioVac System for Thrombus Aspiration From the Ascending Aorta
Authors: Tsilimparis Nikolaos , Spanos Konstantinos , Debus E. Sebastian , Rohlffs Fiona , Kölbel Tilo
Published: August 2018

Purpose: To present the technique for removing mural thrombus from the ascending aorta using the AngioVac System. Technique: The technique is demonstrated in a 66-year-old woman who presented with free-floating mural thrombus in the ascending aorta and was considered unsuitable for either open (comorbidities) or endovascular approaches (high risk of stroke). Because of the free-floating thrombus, the Angiovac system was suggested, although it is approved for only the venous system. The technique was adapted for the arterial system with the 2 access points being (1) the proximal left subclavian artery with a 10-mm conduit for device access and (2) the right femoral vein. The AngioVac cannula and the reinfusion cannula were inserted into the artery and vein, respectively. The extracorporeal bypass circuit was created, and the carotid arteries were clamped during aspiration (<1 minute). The mural thrombus was aspirated successfully. The patient had an uneventful postoperative course with no signs of free thrombus on the postoperative or follow-up computed tomography angiograms. Conclusion: The use of the AngioVac System seems to be a feasible technique for aspiration of thrombus from the ascending aorta. Expanding this therapeutic option for patients unsuitable for open or endovascular repair may be proven efficient in the near future.
EMDR as a Treatment Approach of PTSD Complicated by Comorbid Psychiatric, Somatic, and Cognitive Disorders: A Case Report of an Older Woman With a Borderline and Avoidant Personality Disorder
Authors: Gielkens Ellen M. J. , Sobczak Sjacko , Rossi Gina , Rosowsky Erlene , van Alphen S. J. P.
Published: August 2018

Traumatic life events can result in severe psychiatric conditions among which posttraumatic stress disorder (PTSD) is the most prevalent. Due to high comorbidity with other psychiatric diagnoses, PTSD treatment is challenging. In older adults, the presentation of PTSD symptoms is especially complicated because of even higher comorbidity, higher rates with other mental disorders, and cognitive and somatic conditions. Eye movement desensitization and reprocessing (EMDR) is an evidence-based treatment for trauma in younger adults. There is limited empirical research on the treatment effects of EMDR in older adults. Moreover, the impact of successful EMDR treatment on the comorbid disorders, especially personality and cognitive dysfunctions, is unclear. In this case report, EMDR treatment effects for late-onset PTSD with comorbid borderline and avoidant personality disorders, as well as cognitive disorders and multiple somatic problems, will be presented in an older woman.
Symptomatic Iliofemoral and Iliocaval Venous Thrombosis in Patients With Cancer: Endovascular Treatment
Authors: Rabellino Martin , Moltini Pedro , Di Caro Vanesa , García-Mónaco Ricardo
Published: August 2018

Introduction:

Proximal (iliocaval and iliofemoral) deep vein thrombosis (DVT) and pulmonary thromboembolism are the second cause of death in patients with cancer.

Material and Methods:

A retrospective analysis was performed in 35 patients with cancer treated with endovascular therapy for proximal DVT. The primary objective was to evaluate the technical success of the procedure and the 30-day and long-term symptom improvement.

Results:

Thirty-five patients with a mean age of 57.7 years were treated. In 27 patients, DVT was due to tumor compression and/or invasion of the iliocaval venous axis, and in the remaining 8, it was secondary to their hypercoagulability state. The revascularization techniques used were manual catheter-directed aspiration of the thrombus plus angioplasty and stenting. Technical success was achieved in 33 patients. No complications occurred. Twenty-seven patients were followed up at 30 days posttreatment: 21 were free of postthrombotic syndrome, 4 (14.8%) had mild symptoms, and 2 (7.4%) had moderate symptoms. The mean long-term follow-up was 27.3 months, with a primary patency of 68.8% and assisted and secondary patency rates of 100%.

Conclusion:

Endovascular revascularization in patients with cancer with extensive and symptomatic proximal DVT is safe and efficient, with a low rate of complications. We consider that this therapy should be offered to patients with cancer with an average or long life expectancy.
Development of kinematic simulation system for high-speed press line automated feeding robot
Authors: Zhang Zhulin , Ding Dong , Yu Luchuan , Zhao Xianjin , Zhang Jianhua , Zhang Zhigang , Zhang Qinhe
Published: August 2018

High-speed press lines are related to the fierce competition in the automobile industry and rely on continuous high-efficiency automated feeding systems. Kinematic simulation systems have facilitated the improvement of production processes by generating real-time kinematic curves to avoid interference in feeding systems. In this article, a new method based on quintic polynomials in MATLAB and ADAMS is introduced to achieve whole-line planning using a kinematic simulation system for path planning. Furthermore, secondary interface is developed to visualize the kinematic curves and animate the generated whole-line trajectories. The kinematic simulation system was found to improve the efficiency of generating predicted trajectories in joint or Cartesian space and achieved reliable whole-line path planning, including collision inspection and singular point detection, by using parametric modeling and analyzing kinematic curves. Finally, the kinematic simulation system was verified using results of a kinematic analysis and example simulation.
Recent developments and new frontiers in childhood arterial ischemic stroke
Authors: Mackay Mark T , Steinlin Maja
Published: August 2018

This review will discuss important developments in childhood arterial ischemic stroke over the past decade, focusing on improved understanding of the causes, consequences, and targets for intervention. Risk factors for childhood arterial ischemic stroke are different to adults. Infections, particularly herpes group viruses, are important precipitants for stroke. Non-atherosclerotic arteriopathies are the most common cause of childhood arterial ischemic stroke and an important predictor of recurrent events. Recent advances include the identification of serum biomarkers for inflammation and endothelial injury, and imaging biomarkers to monitor for vascular progression. Multicenter trials of immunotherapies in focal cerebral arteriopathies are currently in development. Recognition of clinical and radiological phenotypic patterns has facilitated the discovery of multisystem disorders associated with arterial ischemic stroke including ACTA2 arteriopathy and adenosine deaminase 2 deficiency. Identification of these Mendelian disorders provide insights into genetic mechanisms of disease and have implications for medical and surgical management. In contrast to adults, there are long diagnostic delays in childhood arterial ischemic stroke. Refinement of pediatric Code Stroke protocols and clinical decision support tools are essential to improve diagnostic certainty and improve access to reperfusion therapies. Children do not recover better than adults following arterial ischemic stroke, with more than half of survivors having long-term impairments. The physical, cognitive, and behavioral consequences of childhood arterial ischemic stroke are increasingly reported but further research is required to understand their impact on participation, quality of life, psychosocial, and family functioning. Longitudinal studies and the use of advanced imaging techniques, to understand neurobiological correlates of functional reorganization, are essential to developing targeted intervention strategies to facilitate recovery.
New tools for doctor: Keeping you ‘appy’
Authors: Gandhi Hussain
Published: August 2018

Medicine is a career of change. In the UK, we are subject to change on a particularly frequent basis. Over the past few years we have seen a data revolution and moved from reading articles in physical publications and ‘googling’ patient symptoms on a desktop to now using smart phones in our pockets or wearables on our wrists to both receive and create data for managing health. This article aims to explore this growing world and summarise key web or app-based resources that clinicians may find helpful in their clinical or organisational lives, in practice and to support patients. This list is not exhaustive, and things, as in many aspects of a fast-moving modern world, may have progressed further by the time this article is published. However, many of the principles will act as a guide for clinicians wishing to ‘plug in’, ‘log in’ and explore.
Modeling and Staging of Osteoarthritis Progression Using Serial CT Imaging and Arthroscopy
Authors: Flynn Candace , Hurtig Mark , Lamoure Emma , Cummins Erin , Roati Valeria , Lowerison Mark , Jeong Sang Young , Oh Wonil , Zur Linden Alex
Published: August 2018

Objective

The objective of this study was to describe in life methods by which osteoarthritis can be staged in order to time therapeutic interventions that are relevant to osteoarthritis (OA) clinical trials

Methods

Twenty-two sheep underwent arthroscopic meniscal destabilization to induce OA. Serial computed tomography (CT) imaging and arthroscopy were used to monitor osteoarthritis progression at 3-month intervals over 9 months. Eleven sheep received 1 intra-articular injection of hyaluronate 3 months after OA induction and another group of 11 received saline. A linear mixed model was used to define the trajectory of shape change in the medial joint compartment. Ordinal logistic regression was used to investigate the association between morphological changes and sclerosis.

Results

Three months after meniscal destabilization there were early bipolar chondral lesions in the medial compartment of the knee, as well as osteophytes and bone remodeling. Superficial fissures and cartilage cracks progressed to discrete areas of cartilage thinning and fibrillation on the medial tibial plateau by 6 months that became cartilage erosions by nine months. A linear mixed effect model demonstrated significant change in medial compartment length and width with over time ( P < 0.05) for both groups. A significant association between severity of sclerosis and medial compartment morphology was also observed.

Conclusions

The induction of osteoarthritic lesions with meniscal release model can be followed using noninvasive and minimally invasive procedures allowing for real-time decisions about redosing therapies, or other changes such as extending trial timelines without sacrificing animals to conduct assessments.
Maintenance of chondrocyte phenotype during expansion on PLLA microtopographies
Authors: Costa Elisa , González-García Cristina , Gómez Ribelles José Luis , Salmerón-Sánchez Manuel
Published: August 2018

Articular chondrocytes are difficult to grow, as they lose their characteristic phenotype following expansion on standard tissue culture plates. Here, we show that culturing them on surfaces of poly(L-lactic acid) of well-defined microtopography allows expansion and maintenance of characteristic chondrogenic markers. We investigated the dynamics of human chondrocyte dedifferentiation on the different poly(L-lactic acid) microtopographies by the expression of collagen type I, collagen type II and aggrecan at different culture times. When seeded on poly(L-lactic acid), chondrocytes maintained their characteristic hyaline phenotype up to 7 days, which allowed to expand the initial cell population approximately six times without cell dedifferentiation. Maintenance of cell phenotype was afterwards correlated to cell adhesion on the different substrates. Chondrocytes adhesion occurs via the α5 β1 integrin on poly(L-lactic acid), suggesting cell–fibronectin interactions. However, α2 β1 integrin is mainly expressed on the control substrate after 1 day of culture, and the characteristic chondrocytic markers are lost (collagen type II expression is overcome by the synthesis of collagen type I). Expanding chondrocytes on poly(L-lactic acid) might be an effective solution to prevent dedifferentiation and improving the number of cells needed for autologous chondrocyte transplantation.
The Dove in the Story of Jesus’ Baptism: Early Christian Interpretation of a Jewish Image
Authors: Somov Alexey
Published: August 2018

The expression “like a dove” in Mark 1.10 is syntactically related either to “Spirit” or “descending.” Although a dove was often interpreted as the symbol of the Spirit in later Christian tradition, such imagery is not found in Jewish and early Christian texts of the first century. In my paper I demonstrate that this expression resonates with Gen 1.2; 4Q521; Odes of Solomon 28:1; the Babylonian Talmud tractate Ḥagigah 15a; and Genesis Rabbah 2.4 as connected with the description of how the Spirit hovers (like a bird) over the righteous. This symbolism was adopted by the pre-Gospel tradition about Jesus’ baptism to specify the manner in which the Spirit descended upon Jesus.
Do We Need Another Greek New Testament? A Translator’s and Student’s Look at the Tyndale House Greek New Testament
Authors: Gross Carl
Published: August 2018

Review of The Greek New Testament, Produced at Tyndale House Cambridge. Edited by Dirk Jongkind, Peter J. Williams, Peter M. Head, and Patrick James. Wheaton, IL: Crossway Books; Cambridge: Cambridge University Press, 2017.
Disambiguating Babylon
Authors: Komen Erwin R.
Published: August 2018

Translating the name “Babylon” in some languages requires that a choice be made whether the name refers to a city, a nation, or a country. This article discusses how the meaning can be determined on the basis of the immediate context, the larger context, the occurrence of collocations, and by logical inferences. It discusses the additional problems related to places where “Babylon” is personified and where it is used metonymically. An appendix contains a list of suggested choices. The procedures provided here can be applied to similar disambiguation problems for other names, such as Judah and Israel.
EndoART: A proposed randomized controlled trial on endometriomas in assisted reproductive technologies, comparing the effect of no intervention, surgery, and prolonged GnRH downregulation on pregnancy rates
Authors: Tomassetti Carla , Adamson David , Arici Aydin , Canis Michel , Hompes Peter , Hummelshoj Lone , Mol Ben-Willem , Nardo Luciano , Rombauts Luk , D’Hooghe Thomas
Published: August 2018

Background:

Clinical management of endometriomas, prior to starting treatment with assisted reproductive technologies (ART), has since long been a matter of debate. Whereas cystectomy has been advocated in the past, recently more evidence has emerged on the potential negative effect of surgery on ovarian reserve. Parallel to this, prolonged downregulation with GnRH-a (gonadotropin-releasing hormone agonists) has been described to improve ART pregnancy rates in women with endometriosis. However, none of these strategies have been assessed in a large randomized controlled trial. The aim of the EndoART study is to assess whether ovarian surgery or prolonged GnRH-a downregulation result in higher pregnancy rates after ART compared to no intervention in women with endometrioma(s).

Methods/design:

A parallel randomized multi-center trial has been designed to compare ART pregnancy rates in three different treatment groups: no intervention, ovarian surgery, and prolonged hormonal suppression by GnRH-a prior to ART. The primary outcome measure studied is the clinical pregnancy rate with fetal heart-beat within 6 months after initiation of a fresh ART cycle. Secondary outcome measures studied include live birth rate after one initiated fresh ART cycle, cumulative clinical pregnancy rate with fetal heart-beat and live birth rates (after one fully completed ART cycle: initiated fresh + eventual associated frozen embryo transfer cycles), ART–specific data (e.g. number of oocytes, number of good quality embryos), complications, pelvic pain, and quality of life.

Conclusion:

This trial may answer the most frequently asked questions by both women with endometriosis and physicians: how do you treat endometrioma in women prior to treatment with ART?
Extending the Discussion: Introductory Improvisation Applications for Elementary Educators
Authors: Torres Ben
Published: August 2018

Based on the concepts introduced in Chandler’s article “Improvisation in Elementary General Music: A Review of the Literature” this “Extending the Discussion” article provides a rhythmic improvisation lesson for primary grades and a melodic improvisation lesson for intermediate grades to assist practicing teachers in pragmatically applying improvisation activities in their classes.
Relating volatiles analysis by GC–MS to Oddy test performance for determining the suitability of museum construction materials
Authors: Samide Michael J. , Liggett Mary C. , Mill Jericha , Smith Gregory D.
Published: August 2018

Conservators’ decisions regarding the suitability of museum construction materials for use in proximity to artworks still rely heavily on accelerated corrosion tests like the Oddy test despite widespread criticisms. These issues include inconveniently long wait times, sensitivity to only those pollutants capable of tarnishing metals, a general sense of unreliability, exaggerated environmental conditions, and subjectivity in assessing the test’s results. Increasingly, alternative strategies that use instrumental approaches involving volatiles sampling coupled to gas chromatography with mass spectrometry (GC–MS) are being explored as faster, more comprehensive, potentially quantitative, and possible more ‘objective’ means of assessing the dangers of off-gassing from museum construction materials. While many of these characteristics are now well documented, the objectivity of the instrumental result is arguable. While the detection of volatiles and semi-volatiles by GC–MS can confidently yield a list of potential pollutants, “chemical intuition” must be used to predict whether many of the emitted compounds can in fact adversely affect artwork. In this study, evolved gas analysis (EGA) coupled to GC–MS is used to predict the suitability of a small sample set of plastics for use in a museum. The potential impact of volatiles observed in the EGA chromatogram was assessed using chemical reactivity principles and the sparse literature data on the material damages caused by a small group of known pollutants. These same plastics were then tested using the British Museum’s 3-in-1 Oddy test. The prediction based on an educated chemical assessment of the compounds identified through instrumental analysis shows good correlation with pooled results from the Oddy test. In one of the two instances of disagreement, the EGA analysis was actually overly conservative and leaned toward prohibiting or restricting a material that passed the Oddy test. In the other, a material that failed the Oddy test but was passed by instrumental analysis was later shown to contain VOCs that could be considered corrosive. This trial suggests that with practice and experience instrumental approaches may be useful to supplement and perhaps one day supplant traditional accelerated corrosion testing of museum construction materials.
The Positive and Negative Syndrome Scale (PANSS): Rationale and Standardisation
Authors: Kay Stanley R. , Opler Lewis A. , Lindenmayer Jean-Pierre
Published: August 2018

Over 75 years ago, Bleuler (1911) confronted psychiatry with the question of ‘schizophrenia’ or ‘schizophrenias'. Today we recognise the heterogeneity of the condition, but we are still groping at efforts to clarify the different subtypes or subprocesses. Over the decades there have been various attempts to subclassify schizophrenia and tease apart the syndromes, none of which has been entirely successful. More recently, as a result of the work by Crow (1980) in England and Strausset al(1974) in the USA, it has been proposed that two distinct syndromes can be discerned from the phenomenological profiles. The positive syndrome consists of productive features superadded to the mental status, such as delusions, hallucinations, and disorganised thinking. The negative syndrome represents absence of normal functions, such as deficits in the cognitive, affective, and social realms.