bluuebunny/crossref_metadata_2025 huggingface dataset:
Response strategies and biological applications of organic fluorescent thermometry: cell- and mitochondrion-level detection
Authors: Li Shuai , Li Yaoxuan , Zhang Shiji , Fang Haixiao , Huang Ze , Zhang Duoteng , Ding Aixiang , Uvdal Kajsa , Hu Zhangjun , Huang Kai , Li Lin
Published: March 2024

In this review, we primarily summarized four temperature-response strategies. Then, we further analyzed the chemical modifications and biological applications of the probes. Finally, we have provided a prospective on the future development of probes.
Engineering cell-free systems by chemoproteomic-assisted phenotypic screening
Authors: Levitskaya Zarina , Ser Zheng , Koh Hiromi , Mei Wang Shi , Chee Sharon , Sobota Radoslaw Mikolaj , Ghadessy John F.
Published: March 2024

Phenotypic screening identified drugs capable of improving the yeast lysate cell-free protein synthesis (CFPS) yield. A drug target gene identified using mass spectrometry proteomics was deleted to yield a yeast strain with higher productivity CFPS.
Enhancement of CO2 adsorption and separation in basic ionic liquid/ZIF-8 with core–shell structure
Authors: Nie Shiyu , Liu Encheng , Chen Fengfeng , Ma Yilin , Chen Kai , Gao Junkuo
Published: March 2024

Proposed core–shell type [Emim]2[IDA]/ZIF-8 structure for highly efficient CO2/N2 separation.
Ni-catalyzed undirected and regioselective acceptorless dehydrogenative silylation of primary benzylic C(sp3)–H bonds
Authors: Yu Qing , Yatabe Takafumi , Matsuyama Takehiro , Yabe Tomohiro , Yamaguchi Kazuya
Published: March 2024

Here, an undirected acceptorless dehydrogenative silylation of benzylic C(sp3)–H bonds was developed using a CeO2-supported highly dispersed Ni(0) nanocatalyst.
Resilience of the Aurivillius structure upon La and Cr doping in a Bi5Ti3FeO15 multiferroic
Authors: Salas Omar Alejandro , Getahun Yohannes W. , Mandujano H. Cein , Manciu Felicia , Castellanos Mariana , Lopez Jorge , Garza Hernández Raquel , Buturlim Volodymir B. , Gofryk Krzysztof , Bairwa Dhanpal , Elizabeth Suja , Nair Harikrishnan S.
Published: March 2024

We have studied the influence of La and Cr doping on the crystal structure and magnetism of Aurivillius multiferroic Bi5Ti3FeO15 and demonstrated the resilience of this structure type.
Biomass derived Cu2O nanoparticles for N-atom insertion reactions: a base-free synthesis of quinazolinones with a green approach
Authors: R. Thrilokraj , Małecki Jan Grzegorz , Budagumpi Srinivasa , Kshirsagar Umesh A. , Dateer Ramesh B.
Published: March 2024

This work describes the use of an eco-friendly biogenic approach for the synthesis of Cu2O NPs utilizing Cucumis melo peel extract for the first time and employed for the one-pot multicomponent synthesis of quinazolinones in a green solvent.
Rapid microwave-assisted synthesis and characterization of a novel CuCoTe nanocomposite material for optoelectronic and dielectric applications
Authors: Supriya Swikruti , Das Subhashree , Samal Satish K. , Senapati Subrata , Naik Ramakanta
Published: March 2024

A ternary CuCoTe-based nanocomposite was synthesised using the rapid microwave technique by varying power and irradiation time. The obtained nanoparticles demonstrate better optical and dielectric properties suitable for optoelectronic applications.
Recent advances in the interfacial engineering of MOF-based mixed matrix membranes for gas separation
Authors: Yu Shuwen , Li Conger , Zhao Shuke , Chai Milton , Hou Jingwei , Lin Rijia
Published: March 2024

This is a comprehensive review for resolving compatibility challenges in fabricating practical metal–organic framework composite membranes for gas separation.
Characterisation of formulated high-density poly(ethylene) by magic angle spinning nuclear magnetic resonance
Authors: Rose Alyssa M. , McLauchlin Andrew R. , Wilson George , McDonald Tom O. , Blanc Frédéric
Published: March 2024

Solid-state 13C nuclear magnetic resonance spectroscopy reveals contrasting differences in the concentration of the various domains in formulated high-density poly(ethylene).
An iron-catalyzed nitrene transfer reaction of nitrosobenzenes with N-acyloxyamides for accessing N-acyl azoxy molecules
Authors: Huang Weimin , Yan Haobo , Wang Qianqian , Chen Jianhui , Luo Yanshu , Xia Yuanzhi
Published: March 2024

A nitrene transfer reaction of nitrosobenzenes with N-acyloxyamides using FeCl2·4H2O as a cheap and commercially available catalyst was developed for facile synthesis of N-acyl azoxy compounds with high functional-group compatibility.
Accurate assembly of thiophene-bridged titanium-oxo clusters with photocatalytic amine oxidation activity
Authors: Nai Haoran , Hou Jinle , Li Jinyu , Ma Xiaoxi , Yang Yujia , Qu Konggang , Huang Xianqiang , Li Lianzhi
Published: March 2024

We synthesized a crystalline dumbbell-shaped Ti10, which effectively enhances charge transfer. As a result, it exhibits remarkably high conversion activity and selectivity in the photocatalytic oxidative coupling reaction of benzylamine.
Recent advances in photoelectrochemical platforms based on porous materials for environmental pollutant detection
Authors: Liu Shiben , Zhan Jinhua , Cai Bin
Published: March 2024

This review investigated the breakthroughs in porous photoactive materials such as metal oxides, metal–organic frameworks, covalent organic frameworks, graphitic carbon nitride, and MXene for the PEC detection of environmental contaminants.
Linker engineering in UiO-68-type metal–organic frameworks for the photocatalytic thioamide cyclization
Authors: Liu Hua , Zhao Shu-Ya , Li Quan-Quan , Li Xu-Sheng , He Yu-Jie , Liu Ping , Wang Yao-Yu , Li Jian-Li
Published: March 2024

A mild, green, and sustainable visible-light-driven synthesis of 1,2,4-thiadiazole using a linker engineering method for systematically tuning the light absorption and charge-separation behavior is reported.
An Exploration of Associations Between Self-Care Practices and Clinical Self-Efficacy in Speech-Language Pathology Graduate Students
Authors: Findley Brooke R.
Published: March 2024

Purpose:

Previous studies have suggested that many speech-language pathology graduate students experience significant levels of stress throughout their programs. If not effectively mitigated, these stressors could negatively impact students' academic and clinical development. Self-care practices are one potential option that could help address the stressors students encounter throughout their graduate programs. The purpose of this research was to explore potential associations between self-care practices and clinical self-efficacy in speech-language pathology graduate students.

Method:

This topic was explored using a nonexperimental research design that included descriptive and correlational analyses. A survey that included demographic questions, the Mindful Self-Care Scale–Standard, and a modified version of the Clinical Self-Efficacy Appraisal Inventory was completed by 68 students who were enrolled in a speech-language pathology graduate program.

Results:

Small positive and significant correlational associations were observed between Mindful Awareness and total Mindful Self-Care Scale–Standard scores and all measured aspects of clinical self-efficacy. The associations between Supportive Relationships and Supportive Structure subscale scores and some aspects of clinical self-efficacy also reached significance. No significant associations were observed between Mindful Relaxation, Physical Care, or Self-Compassion and Purpose subscale scores and any measured domain of clinical self-efficacy.

Conclusion:

While limitations exist due to the exploratory nature of this study, the results provide an initial examination of associations between self-care practices and clinical self-efficacy.
Two‐step attribute reduction for AIoT networks
Authors: Ren Chao , Lyu Gaoxin , Wang Xianmei , Huang Yao , Li Wei , Sun Lei
Published: March 2024

The evolution of Artificial Intelligence of Things (AIoT) pushes connectivity from human‐to‐things and things‐to‐things, to AI‐to‐things, has resulted in more complex physical networks and logical associations. This has driven the demand for Internet of Things (IoT) devices with powerful edge data processing capabilities, leading to exponential growth in device quantity and data generation. However, conventional data preprocessing methods, such as data compression and encoding, often require edge devices to allocate computational resources for decoding. Additionally, some lossy compression methods, like JPEG, may result in the loss of important information, which has negative impact on the AI training. To address these challenges, this paper proposes a two‐step attribute reduction approach, targeting devices and dimensions, to reduce the massive amount of data in the AIoT network while avoiding unnecessary utilization of edge device resources for decoding. The device‐oriented and dimension‐oriented attribute reductions identify important devices and dimensions, respectively, to mitigate the multimodal interference caused by the large‐scale devices in the AIoT network and the curse of dimensionality associated with high‐dimensional AIoT data. Numerical results and analysis show that this approach effectively eliminates redundant devices and numerous dimensions in the AIoT network while maintaining the basic data correlation.
Constructing prediction intervals for circuit board fault detection: A neural network approach using VI Curve
Authors: Pan Qingguo , Zhao Yan , Zhao Zheng , Lin Peng
Published: March 2024

The accuracy and reliability of circuit board fault detection are significantly influenced by the uncertainty inherent in the VI curve. Here, an ensemble neural network is proposed, which combines the neural network‐based prediction interval and ensemble approaches, to improve the accuracy of fault detection using the VI curve. First, a loss function with multiple objectives is formulated by integrating curve fitting and prediction interval. The aim is to achieve the curve fitting between current and voltage while simultaneously determining the optimal upper and lower bounds of the prediction interval. Second, an ensemble approach is employed to reduce model uncertainty and derive the ultimate current predictions and intervals. These predictions and intervals are then used in a comparative approach to automatically detect faults in circuit boards. Finally, the effectiveness of the proposed algorithm in improving the accuracy of fault detection is verified on experimental circuit boards.
Electronic structure, oscillator strength, and rovibrationally resolved photodissociation of 24MgH
Authors: Deng Zhihao , Li Na , Kun Yang Yu , Gong Maomao , Yan Bing , Wu Yong , Guo Wang Jian , Cheng Yongjun , Bin Zhang Song
Published: March 2024

Aims. A series of high-precision calculations for the electronic structure of MgH have been reported in the past two decades; however, most of them d not include the core-valence correlation and still exhibit distinct differences. Furthermore, the latest high-precision results have not been applied to the studies of photodissociation dynamics. The primary motivations of this paper are to calculate a more precise electronic structure of MgH consering a core-valence correlation and to prove the photodissociation cross-sections.

Methods. The electronic structure of MgH is investigated by multi-reference configuration interaction calculations with Davson correction (MRCI+Q). We performed two different sets of calculations to investigate the core-valence correlation and, as a result, obtained accurate potential energy curves (PECs) and transition dipole moments (TDMs). An extrapolation procedure was also employed to eliminate the error of basis set. Then, the photodissociation cross-sections were calculated using high-precision PECs and TDMs.

Results. The PECs and TDMs of the five lowest doublet electronic states, X2Σ+, B′2Σ+, E2Σ+, A2Π, and C2Π, are obtained from calculations including core-valence correlation, termed as CV-MRCI, while PECs of the ten lowest doublet states and three quartet states are also obtained from NCV-MRCI calculations without core-valence correlation. The spectroscopic constants and band oscillator strengths are also proved with high precision levels. The equilibrium Re and vertical excitation energy Te are only 0.1% different from the measurements. Based on the CV-MRCI results, the rovibrationally resolved photodissociation cross-sections for transitions from X2Σ+ to the other four states, as well as the total local thermodynamic equilibrium cross-sections for temperatures up to 10000 K, are calculated.
A “MeerKAT-meets-LOFAR” study of the complex multi-component (mini-)halo in the extreme sloshing cluster Abell 2142
Authors: Riseley C. J. , Bonafede A. , Bruno L. , Botteon A. , Rossetti M. , Biava N. , Bonnassieux E. , Loi F. , Vernstrom T. , Balboni M.
Published: March 2024

Context. Clusters of galaxies are known to be turbulent environments, whether they are merging systems where turbulence is injected via the conversion of gravitational potential energy into the intracluster medium (ICM), or whether they are relaxed systems in which small-scale core sloshing is occurring within the potential well. In many such systems, diffuse radio sources associated with the ICM are found: radio haloes and mini-haloes.

Aims. Abell 2142 is a rich cluster undergoing an extreme episode of core sloshing, which has given rise to four cold fronts and a complex multi-component radio halo. Recent work revealed that there are three primary components to the halo that spans a distance of up to around 2.4 Mpc. The underlying physics of particle acceleration on these scales is poorly explored, and requires high-quality multi-frequency data with which to perform precision spectral investigation. We aim to perform such an investigation.

Methods. We used new deep MeerKAT L-band (1283 MHz) observations in conjunction with LOFAR HBA (143 MHz) data as well as X-ray data from XMM-Newton and Chandra to study the spectrum of the halo and the connection between the thermal and non-thermal components of the ICM.

Results. We confirm the presence of the third halo component, detecting it for the first time at 1283 MHz and confirming its ultra-steep spectrum nature, as we recovered an integrated spectrum of αH3,  total = −1.68 ± 0.10. All halo components follow power-law spectra with increasingly steep spectra moving towards the cluster outskirts. We profiled the halo in three directions, finding evidence of asymmetry and spectral steepening along an axis perpendicular to the main axis of the cluster. Our investigation of the thermal non-thermal connection shows sub-linear correlations that are steeper at 1283 MHz than 143 MHz, and we find evidence of different connections in different components of the halo. In particular, we find both a moderate anti-correlation (H1, the core) and positive correlation (H2, the ridge) between the radio spectral index and X-ray temperature.

Conclusions. Our results are broadly consistent with an interpretation of turbulent (re-)acceleration following an historic minor cluster merger scenario in which we must invoke some inhomogeneities. However, the anti-correlation between the radio spectral index and X-ray temperature in the cluster core is more challenging to explain; the presence of three cold fronts and a generally lower temperature may provide the foundations of an explanation, but detailed modelling is required to study this further.
PDRs4All
Authors: Schroetter Ilane , Berné Olivier , Joblin Christine , Canin Amélie , Chown Ryan , Sidhu Ameek , Habart Emilie , Peeters Els , Lai Thomas S.-Y. , Candian Alessandra , Chakraborty Shubhadip , Petrignani Annemieke , Trahin Boris , Van De Putte Dries , Alarcón Felipe
Published: March 2024

Aromatic infrared bands (AIBs) are a set of broad emission bands at 3.3, 6.2, 7.7, 8.6, 11.2, and 12.7 μm, seen in the infrared spectra of most galaxies. With the James Webb Space Telescope (JWST), the 3.3 μm AIB can in principle be detected up to a redshift of ~7. Relating the evolution of the 3.3 μm AIB to local physical properties of the interstellar medium (ISM) is thus of paramount importance. By applying a dedicated machine learning algorithm to JWST NIRSpec observations of the Orion Bar photodissociation region obtained as part of the PDRs4All Early Release Science (ERS) program, we extracted two template spectra capturing the evolution of the AIB-related emission in the 3.2–3.6 μm range, which includes the AIB at 3.3 μm and its main satellite band at 3.4 μm. In the Orion Bar, we analyzed the spatial distribution of the templates and their relationship with the ro-vibrational H2 line at 2.12 μm, the pure rotational line of H2 at 4.69 μm and the Pfund δ line at 3.29 μm. We find that one template (AIBIrrad) traces regions of neutral atomic gas with strong far-UV fields, while the other template (AIBShielded) corresponds to shielded regions with lower FUV fields and a higher molecular gas fraction. We then show that these two templates can be used to fit the NIRSpec AIB-related spectra of nearby galaxies. The relative weight of the two templates (AIBIrrad/Shielded) is a tracer of the radiative feedback from massive stars on the ISM. We derive an estimate of AIBIrrad/Shielded in a z = 4.22 lensed galaxy and find that it has a lower value than for local galaxies. This pilot study illustrates how a detailed analysis of AIB emission in nearby regions can be used to probe the physical conditions of the extragalactic ISM.
Spatially resolving the AGB star V3 in the metal-poor globular cluster 47 Tuc with VLTI/GRAVITY
Authors: Ohnaka K. , Weigelt G. , Hofmann K.-H. , Schertl D.
Published: March 2024

Context. Mass loss at the asymptotic giant branch (AGB) plays an important role not only in the final fates of stars, but also in the chemical evolution of galaxies. Nevertheless, the metallicity effects on AGB mass loss are not yet fully understood.

Aims. We present spatially resolved observations of an AGB star, V3, in the metal-poor globular cluster 47 Tuc (NGC 104).

Methods. The AGB star 47 Tuc V3 was observed using the GRAVITY instrument at ESO’s Very Large Telescope Interferometer (VLTI) at 2–2.45 μm, with a projected baseline length of up to 96 m.

Results. The object 47 Tuc V3 has been spatially resolved and stands as the first to attempt to spatially resolve an individual star in a globular cluster. The uniform-disk fit to the observed data results in an angular diameter of ∼0.7 mas. Our modeling of the spectral energy distribution and near-infrared interferometric GRAVITY data suggests that the observed data can be explained by an optically thin dust shell with a 0.55 μm optical depth of 0.05–0.25, consisting of metallic iron grains, likely together with effects of the extended atmosphere of the central star. The dust temperature at the inner shell boundary is 500–800 K (corresponding to 23–90 stellar radii), significantly lower than observed in nearby oxygen-rich AGB stars. Radiation pressure on small (< 0.05 μm) iron grains is not sufficient to drive stellar winds. Therefore, iron grains may grow to larger sizes, even in the metal-poor environment. Alternatively, it is possible that the observed iron grain formation is a result of the mass outflow initiated by some other mechanism(s).

Conclusions. The sensitivity and angular resolution of VLTI provides a new window onto spatially resolving individual stars in metal-poor globular clusters. This allows us to improve subsequent studies of the metallicity dependence of dust formation and mass loss.
TESS photometry and CAOS spectroscopy of six eclipsing binaries with Am components
Authors: Catanzaro G. , Frasca A. , Alonso-Santiago J. , Colombo C.
Published: March 2024

In this paper, we present the results of a comprehensive study of six eclipsing binaries whose components are confirmed or suspected Am stars. By combining long-term, high-resolution Catania Astrophysical Observatory Spectropolarimeter (CAOS) spectroscopy and TESS photometry, we have been able to accurately obtain the orbital parameters of each system as well as the atmospheric parameters of its components. We performed an in-depth chemical analysis and provided chemical abundances of C, O, Na, Mg, Si, Ca, Sc, Ti, Cr, Mn, Fe, Ni, Zn, Sr, Y, Zr, and Ba. From the solution of the light and radial curves, we have determined the masses, radii, and temperatures with a good degree of accuracy. We observe apsidal motion in the eccentric system HD 216429, in which the Rossiter-McLaughlin effect is also noted. We inferred the age of our targets by fitting isochrones on the HR diagram and find that both components in each system are properly described with the same isochrone, which reinforces our results. Furthermore, dynamical and evolutionary masses, independently obtained, show an excellent agreement. According to the out-of-eclipse variability shown in their TESS light curves and their position on the Hertzsprung-Russell diagram, we claim that the stars HD 42954 (as δ Sct type) and HD 151604 (γ Dor) have a pulsating nature. Based on the chemical analysis, we corroborate that four of the systems studied here are formed by Am stars, while in the remaining ones (HD 126031 and HD 216429) only the primary component exhibits a peculiar composition. Additionally, the age distribution found in Am stars supports their suitability as age tracers in stellar populations.
Integral assessment of low-carbon energy sources effectiveness based on multi-criteria analysis
Authors: Dvinin Dmitry , Davankov Aleksey , Malygin Nikita , Sidelnikov Pavel
Published: March 2024

The study applies the multi-criteria analysis of various low-carbon energy sources to assess their ecological and economical effectiveness. The work is specific by researching renewable energy sources as well as traditional ones which take hydrocarbon fuel by using innovative technologies of carbon dioxide capturing and its storage. The analysis applies three parameters: LCOE (Levelised Cost of Energy)/LEC (Levelized Energy Cost), specific value of carbon dioxide emission in electrical power generation and total MI (Material Input) - numbers. The study results in educing low-carbon energy sources which not only lead to the most reduction of carbon dioxide emission with least costs but also help reduce the general negative impact on the environment due to decreasing violence of biosphere material energy flows. The research states that wind power plants are the most effective, followed by solar and geothermal energy sources. Gas and coal-fired power stations, using technologies of carbon dioxide capturing, are less effective than renewable energy sources. Nevertheless, despite significant divergence in two out of three parameters, they have an identical summative assessment of efficiency because gas power stations have higher utilization costs than coal-fired power stations.
On the foundations of seismic safety of the Kuznetsk Basin
Authors: Solovitskiy Aleksandr
Published: March 2024

The experience of the study of seismicity in Kuzbas in the 21st century has been summarized. An increase in dangerous seismic events in the region has been determined. Given the situation, a new seismic safety technique needs to be developed, based on fundamental studies, which is an important scientific task. Thus, the goal of the study is the development of a seismic safety technique based on complex and continuous instrumental measurements performed to understand the genesis of seismicity and its regional patterns, including the relationship with geodynamics of the Earth’s crust. The fundamental research based on multi-year complex instrumental measurements that take into account the formation and the hierarchy of the crust characterizes the integration of the relationship between the adjacent branches of science (seismology, geophysics, geodesy, geodynamics, and geomechanics). Applicable results of the study include a wider informational source required to assure the seismic safety of Kuzbas.
Influence of the rock massif physical properties variability on the localization of its disturbances with GPR
Authors: Dyakov Andrey , Kalashnik Anatolii
Published: March 2024

An integrated approach to studying the influence of the physical properties of a rock mass on the localization of its disturbances by GPR sounding is considered. The performed studies have established that, during GPR sounding of rock masses, there is a distortion of the induced electromagnetic field in areas with different physical properties of rocks (such as: massif heterogeneity, rock fracturing, zones of increased water saturation, etc.). Regularities in the formation of wave patterns of GPR model data (changes in the in-phase axes and amplitude characteristics of the signal) of a rock mass containing structural inhomogeneities are revealed. During GPR sounding of such a rock mass, reflections from the edge parts of inhomogeneities appear in the wave patterns in the form of branches of hyperbolas. The intensity of the wave field distortion is determined by the contrast of the physical properties of rocks, as well as the spatial orientation and depth of heterogeneities, which is a key parameter of GPR sounding. It has been established that the variability of the physical properties of rocks in a rock mass near faults introduces significant distortions in the parameters determined by GPR sounding, including the angle of incidence of faults.
A method for extracting oil from a field with hard-to-recover reserves based on systems analysis methodology
Authors: Ospanov Yerbol , Smailova Ulmeken , Mukhametov Yeldos , Zhapar Botagoz , Zhienbek Araylym , Khidoyatov Salavat , Nazarov Rashid
Published: March 2024

The article examines the problems of solving the problem of optimizing oil production processes from a field with hard-to-recover oil reserves, characterized by shortages and fuzziness of the initial information. Equations for the continuity of the mass of matter in an oil reservoir have been derived for various cases. As a result of the study, by combining and modifying various optimality principles for fuzzy conditions, a formulation of the problem of multi-criteria optimization of oil production processes was obtained and an effective method for the resulting problem in a fuzzy environment was proposed. The effectiveness and novelty of the proposed heuristic algorithm lies in the fact that for the maximum use of the collected fuzzy information, it ensures high adequacy of solving fuzzy problems that arise in oil production practice. The sections of the studied multi-layer oil field Kenbai and the main properties of its layers are analyzed and described.
Optimization of Calorific Value in Briquette made of Coconut Shell and Cassava Peel by varying of Mass Fraction and Drying Temperature
Authors: Ahmad Sabarudin , Winarso Kukuh , Yusron Rifky , Amar Samsul
Published: March 2024

Coconut shells and cassava peels are agricultural residues that are abundantly produced in places where coconut and cassava processing activities are prevalent. formerly these waste products have been disposed of through incineration or natural decomposition, hence exacerbating air pollution and triggering degradation of the environment. The objective of this research is to determine the optimum combination of mixed mass fraction and drying temperature for briquettes produced from coconut shell and cassava peel. Observed variable on this research was Mass fraction with the ratio of coconut shell and Cassava peel 75:25 as level 1, 70:30 as level 2 and 65:35 as level 3. Drying temperature has 3 level 150oC, 200oC and 250oC. The lowest calorific value achieved in briquette made of 65% coconut shell mix with 35% Cassava peel and drying temperature is 200oC on second replication The highest calorific value achieved in briquette made of 65% coconut shell mix with 35% Cassava peel and drying temperature is 150oC on third replication. Coconut shell has a greater effect than Cassava peel on the calorific value of briquettes, but the chemical content of Cassava peel makes the burning rate longer. According to the outcomes of the normality test, versus fits, histograms, and versus order plots indicate that the data has a normal distribution. based on optimization results using Taguchi L9 and ANOVA optimizer the optimal combination using rule larger better is the mass fraction of coconut shell 70:30 Cassava peel with a drying temperature of 250oC.
Exploring the consumer satisfaction and loyalty of moringa tea in Madura
Authors: Gultom Debora Rosa Linda , Kurniyanto Ifan Rizky , Wusto M. Bahrul
Published: March 2024

Improving customer satisfaction is an essential component of the long-term survival of a business. The increasing number of similar businesses is challenging for business actors to survive in the industrial world. Every business needs to keep its customers satisfied and loyal. This study analyzes consumer satisfaction and loyalty to one of CV Nurul Jannah's processed products, moringa tea. This study uses the IPA-CSI method and Pearson correlation with quantitative research type. The sampling technique was non-random sampling. The results of this study indicate that in the analysis of each attribute with the IPA method, three attributes are in quadrant I to be the owner's top priority in making improvements, namely price comparison with other products, efficacy, and ease of obtaining moringa tea. The CSI value table is known to be 76.43%; this value based on the CSI criteria is between (66.00% - 80.99%) which states that consumers are satisfied. The correlation results show a strong and positive relationship between satisfaction and consumer loyalty of 0.786. CV. Nurul Jannah is expected to add organic compositions, such as honey, etc., to add more efficacy so that consumers feel free to buy at the price offered by the manufacturer. This will create satisfied consumers who will become loyal.
Morphological characteristics of sea cucumbers (Holothuroidea) from Socah Waters, Bangkalan, Madura
Authors: Putri Rizka Rahmana , Abida Indah Wahyuni , Putri Fareza Nabila Dhea Fatma , Innaya Ainnun
Published: March 2024

Sea cucumbers belong to the Phylum Echinodermata with unique and diverse body shape. At the organism level, phenotype is an attribute or characteristic that can be seen, observed, or measured. The study of morphological characteristics in sea cucumbers in the Socah Waters of Bangkalan, Madura is necessary to obtain specific morphological data for different sea cucumber species, allowing us to recognize the distinctive features of each sea cucumber species in the Socah Waters, Bangkalan Regency, Madura. Morphological and morphometric data of a biota that will be used to determine the type and name of the species are preliminary data that are useful for reference in further research. However, of course, in order to determine the type and name of the species more accurately, it should be followed by genetic identification. The method employed in this research was survey method and random sampling techniques to collected various sea cucumber species from the waters. The measurement was conducted on each sea cucumber species, including total length measured from the anterior to the posterior, color, shape, and body patterns. The result showed that the Phyllophorus sp. has a round shape with a body size ranging from 3 to 8 cm, black in color, and small brown spots covering its entire body. The Colochirus sp. has an elongated shape with a body length of 6 to 10 cm, displaying a distinct red and orange body color and a body pattern consisting of ridges with papillae along these ridges. The red sea cucumber also possesses tentacles. The Paracaudina australis has an elongated shape with a transparent white body, featuring white and pinkish-red line patterns. In addition, data of the demographics of sea cucumber fishermen including age, level of education, length of experience, and the purpose of using sea cucumbers, is also needed as a reference for future studies. Knowledge of the demographics of fishermen is also needed to find the suitable method if in the future we will conduct socialization, training, or community service.
The least squares finite element method for elasticity interface problem on unfitted mesh
Authors: Yang Fanyi
Published: March 2024

In this paper, we propose and analyze the least squares finite element methods for the linear elasticity interface problem in the stress-displacement system on unfitted meshes. We consider the cases that the interface is C2 or polygonal, and the exact solution (σ, u) belongs to Hs(div; Ω0 ∪ Ω1) × H1+s(Ω0 ∪ Ω1) with s > 1/2. Two types of least squares functionals are defined to seek the numerical solutions. The first is defined by simply applying the L2 norm least squares principle, and requires the condition s ≥ 1. The second is defined with a discrete minus norm, which is related to the inner product in H−1/2(Γ). The use of this discrete minus norm results in a method of optimal convergence rates and allows the exact solution has the regularity of any s > 1/2. The stability near the interface for both methods is guaranteed by the ghost penalty bilinear forms and we can derive the robust condition number estimates. The convergence rates under L2 norm and the energy norm are derived for both methods. We illustrate the accuracy and the robustness of the proposed methods by a series of numerical experiments for test problems in two and three dimensions.
Seed priming as a method of preservation and restoration of sunflower seeds
Authors: Kaya Mehmet Demir , Ergin Nurgül , Harmancı Pınar , Kulan Engin Gökhan
Published: March 2024

The study focused on determining the preservative and restorative effects of seed priming with gibberellic acid (GA3) and potassium nitrate (KNO3) on sunflower seeds against deterioration. The seeds were immersed in different concentrations (0, 250, 500, and 1000 mg L−1) of GA3and KNO3solutions before and after being subjected to accelerated aging (AA). Unprimed seeds (NT) were used as control. The results showed that AA led to a reduction in germination percentage, germination index, and seedling growth parameters. However, seed primed with GA3had a higher germination percentage after AA than NT. All seed primings shortened mean germination time and improved germination index. Seedling growth was stimulated by seed priming, and seed priming after AA produced more vigorous seedlings than primed seed before AA because they were severely affected by AA. In addition, hydration sufficiently induced the germination and seedling growth of aged seeds. A significant difference was found between GA3and KNO3, and seeds were effectively protected from aging by GA3, while hydration promoted germination of aged seeds. Consequently, the recovery effect of seed priming was more pronounced than the conservative effect, and sunflower seeds should be primed with 500-1000 mg L−1GA3before storage or, if this is not possible, hydration improves the vitality and subsequent growth of aged sunflower seeds.
Eine ambulante Behandlungsweisung wäre hilfreich für die Behandlung
und Deliktprävention bei Menschen mit Psychosen – Pro
Authors: Schwärzler Frank , Frank Udo
Published: March 2024

Mit der verfassungsgerichtlich angestoßenen bundesweiten Überarbeitung der
Landesgesetze zur Unterbringung psychisch kranker Menschen und der Möglichkeit einer
medikamentösen Behandlung wider Willen wurden Fortschritte erreicht für die
Rechtssicherheit von Patient*innen und Behandelnden sowie ein Höchstmaß an
Patientenautonomie angestrebt. Zwangsbehandlungen setzen jedoch meist eine Fremd-
oder Selbstgefährdung voraus und können stets nur im stationären Rahmen durchgeführt
werden. Rechtlich und allgemeinpsychiatrisch steht damit kein Mittel zur
Verhinderung schwerer Rückfälle zur Verfügung.
Hygienestandards im OP – führen sie nachhaltig zur Verbesserung der
Qualität?
Authors: Holz Mathias , Lippross Sebastian , Seekamp Andreas
Published: March 2024

Hintergrund Nosokomiale Infektionen und postoperative Wundinfektionen sind in
Deutschland eine für das Gesundheitssystem und die betroffenen Patientinnen und Patienten
erhebliche Belastung. Eine postoperative Wundinfektion geht oft mit einer massiven
Verschlechterung der Qualität des Behandlungserfolges chirurgischer Maßnahmen bez. der
Patientenbelastung, der funktionellen Ergebnisse und der Wirtschaftlichkeit einer
Behandlung für den Leistungserbringer einher. Ziel dieses Beitrages ist es, die aktuellen
Hygienevorgaben für das perioperative Setting verständlich darzustellen und für alle am
Operationsablauf Beteiligten zu erläutern.

Methode Erläutert wird zunächst die Bedeutung hygienischer Maßnahmen sowie in
einer kurzen Übersicht die Entwicklung bis hin zu modernen Hygienekonzepten der heutigen
Zeit. Anschließend werden die aktuellen Empfehlungen der KRINKO (Kommission für
Krankenhaushygiene und Infektionsprävention beim Robert Koch-Institut): „Prävention
postoperativer Wundinfektionen, Empfehlung der Kommission für Krankenhaushygiene und
Infektionsprävention (KRINKO) beim Robert Koch-Institut“ dargestellt.

Schlussfolgerung Hygienisches Arbeiten ist eine Grundvoraussetzung der Arbeit im
operativen Bereich, denn überzeugende Behandlungsergebnisse mit guten funktionellen
Ergebnissen können in vielen Bereichen (z. B. moderne Endoprothetik) ohne eine suffiziente
Hygiene überhaupt nicht erzielt werden. Die modernen Vorgaben zum hygienischen Arbeiten
sind komplex und betreffen alle Bereiche des Krankenhauses. Nur unter Beachtung aller
Säulen der modernen Hygienekonzepte kann das bestmögliche Maß an Prozessqualität
gewährleistet werden.
Schließung der Notfallversorgungslücke auf Intensivstationen
Authors: Buschmann Tobias , Johlitz Daniel
Published: March 2024

Bei der stationären Versorgung von Patienten stellt sich täglich immer wieder aufs Neue die Frage: Wer kann aufgenommen, wer muss verlegt werden? Sind ausreichend Kapazitäten vorhanden, um eine notwendige intensivpflegerische Versorgung zu gewährleisten? Maßnahmen aus dem Case Management könnten dazu beitragen, Probleme und Fehler beim Aufnahme- und Entlassungsmanagement zu identifizieren und zu analysieren.
Realistische Intuition und virtueller Tod: das Hirntodkonzept auf dem Prüfstand
Authors: Beckmann Rainer
Published: March 2024

Die Pflege von Patientinnen und Patienten mit irreversiblem Hirnfunktionsausfall – umgangssprachlich: Hirntod – ist emotional herausfordernd. Ihr Erscheinungsbild gleicht dem anderer schwer kranker und bewusstloser Patienten auf der Intensivstation. Nach dem sogenannten Hirntodkonzept sollen sie aber bereits tot sein. Gerade für Pflegekräfte wirkt diese Einschätzung kontraintuitiv. Wie gut begründet ist der Hirntod als Todeszeichen?
Rektumkarzinom: neoadjuvante Strategien und total neoadjuvante Therapie
Authors: Hofheinz Ralf-Dieter
Published: March 2024

Die Behandlungsstrategien beim lokal fortgeschrittenen Rektumkarzinom sind stark im
Wandel. Die in den Leitlinien für lokal fortgeschrittene Tumoren uniform empfohlene Therapie
mit neoadjuvanter Radio(chemo)therapie (RChT), gefolgt von Chirurgie und ggf. adjuvanter
Therapie ist mittlerweile zugunsten folgender Konzepte verlassen: 1. verlängerte neoadjuvante
Therapie („mehr Chemotherapie vor der Operation“ als totale neoadjuvante Therapie, TNT,
bezeichnet); 2. Organerhalt bei Patienten mit einem kompletten klinischen Ansprechen nach
einer neoadjuvanten RChT; 3. Verzicht auf Strahlentherapie bei niedrigem Lokalrezidivrisiko;
4. definitive Immuntherapie mit Checkpoint-Inhibitoren bei Patient*innen mit einem
mikrosatelliteninstabilen (MSI) Primärtumor. Im vorliegenden Beitrag sollen ausgehend vom
leitlinienbasierten Status quo diese 4 neuen Strategien und aktuelle Studienkonzepte
diskutiert werden.
Endoskopische Resektionsverfahren von flächigen Präkanzerosen und Frühkarzinomen im Rektum
Authors: Hochberger Jürgen , Loss Martin , Kruse Elena
Published: March 2024

Die Endoskopie spielt heute nicht nur in der Erkennung von kolorektalen Adenomen und
Karzinomen eine entscheidende Rolle, sondern auch in der Behandlung von insbesondere flächigen
Adenomen und frühen Karzinomen. In den letzten Jahren hat neben der klassischen Polypektomie
und Mukosaresektion flach-erhabener Läsionen mit der Schlinge (EMR), die endoskopische
Submukosadissektion (ESD) einen zunehmenden Stellenwert erlangt. Hierbei erfolgt nach
Markierung, Unterspritzung und Inzision der Mukosa um die Läsion, die Untertunnelung und das
„En-bloc“-Auslösen durch eine transparente Aufsatzkappe und ein feines Diathermiemesser.
Gerade bei flächigen Veränderungen mit hohem Rezidivrisiko einer Piecemeal-Resektion durch EMR
sowie bei Risikoläsionen ermöglicht die ESD, nahezu größenunabhängig in der Hand des
Erfahrenen, einen sicheren Abtrag mit einer histologischen R0-Resektionsrate an Zentren von
weit über 90%. Die ESD ermöglicht eine optimale histopathologische Ausbeute und weist ein
niedriges Rezidivrisiko von 1–3% auf. Eine weitere Bereicherung des Armamentariums stellt die
endoskopische Vollwandresektion mit einem speziellen Applikationssystem dar (FTRD-System).
Dieses eignet sich für umschriebene submuköse, suspekte oder narbige Veränderungen bis 2 cm
Größe im mittleren und oberen Rektum. Die endoskopische intermuskuläre Dissektion (EID)
ermöglicht durch Mitnahme der zirkulären inneren Muskelschicht bei der Resektion die
histopathologische Analyse der kompletten Submukosa über Mukosa und obere Submukosaschicht
hinaus. Sie bietet bei T1-Karzinomen ein geringeres Risiko der basalen R1-Situation und eine
neue Perspektive durch die kurative, organerhaltende endoskopische Therapie bei alleiniger
tiefer Submukosainfiltration ohne weitere Risikofaktoren für eine Metastasierung.
Indikationen, Technik und Stellenwert der verschiedenen Techniken bei prämaligen und
frühmaligen Läsionen im Rektum werden dargestellt.
State of the Art Rektumchirurgie
Authors: Conradi Lena-Christin , Haas Gwendolyn , Fleischer Johannes Robert , Ghadimi Michael
Published: March 2024

Die multimodale Therapie des Rektumkarzinoms hat sich über die letzte Dekade erheblich
differenziert je nach Charakteristika des Tumors und Gegebenheiten des Patienten. Die
Operation stellt weiterhin eine wichtige Säule der Therapie dar, deren Qualität von
prognostischer Relevanz für betroffene Patienten ist. Diese Übersicht gibt einen aktuellen
Überblick zur Indikation der verschiedenen chirurgischen Verfahren, aktuellen Entwicklungen
zum perioperativen Management sowie zum Zeitpunkt einer Operation.
Update zum Sjögren-Syndrom: Diagnostik & Therapie
Authors: Zehrfeld Nadine , Witte Torsten , Ernst Diana
Published: March 2024

Mit einer Prävalenz von circa 1:100 bis 1:400 ist das Sjögren-Syndrom die
häufigste Kollagenose und betrifft hauptsächlich Frauen. Bei der Erkrankung
steht die Destruktion der exokrinen Drüsen im Vordergrund und führt so regelhaft
zur Sicca-Symptomatik. In über 50% der Fälle kommt es auch zu extraglandulären
Manifestationen. Insbesondere Fatigue und Arthralgien aber auch verschiedene
systemische Organmanifestationen wie Polyneuropathien oder interstitielle
Lungenerkrankungen können auftreten. PatientInnen mit bestimmten Risikofaktoren
haben eine Wahrscheinlichkeit von fünf Prozent ein Lymphom zu entwickeln. Die
Diagnostik orientiert sich an den aktuellen ACR/EULAR-Klassifikationskriterien,
der Speicheldrüsensonographie, sowie diversen Biomarkern, insbesondere den
Antikörpern gegen SSA/Ro, in Verbindung mit der klinischen Symptomatik. Es gibt
bislang keine zugelassene systemische immunsuppressive Therapie. Die European
League against rheumatism (EULAR) hat Therapieempfehlungen veröffentlicht, die
sich an den Empfehlungen für die Therapie des Systemischen Lupus Erythematodes
orientieren und je nach klinischer Ausprägung und Manifestation variieren.
Verschiedene, durchaus vielversprechende Studien zu unterschiedlichen
therapeutischen Ansätzen werden aktuell durchgeführt.
Two-Year Functional Outcomes of Nonsurgical Treatment in Concomitant Anterior Cruciate Ligament and Medial Collateral Ligament Injuries: A Case-Control Study
Authors: Dadgostar Heleh , Zarrini Mojgan , Hoveidaei Amir Human , Sattarpour Reza , Razi Saeed , Arasteh Peyman , Razi Mohammad
Published: March 2024

The anterior cruciate ligament (ACL) is a common knee injury in high-intensity sports, which can cause early career loss in young athletes. Concomitant damage to other knee stabilizers may occur, such as the medial collateral ligament (MCL). Recent studies have shown that knee stability can increase without surgical intervention in patients with ACL and MCL injuries. Regarding the importance of functional tests in return to exercise prediction, this study aims to measure nonsurgical approach's long-term outcome for concomitant ACL and MCL injuries with a focus on functional tests. This is a case-control study with a 2-year follow-up. The case group consisted of patients who had provided written consent and completed their 2-year follow-up, and the control group was made up of healthy people who did not have any knee medical conditions and were matched by age, gender, and activity level. Physical examinations, Tegner and International Knee Documentation Committee questionnaires, and knee magnetic resonance imaging were conducted, and functional performance tests were performed after a 10-minute warm-up. Lody's index (the ratio of injured-to-uninjured knee results) was calculated. The data were analyzed using independent t-test, one-way analysis of variance, chi-squared test, and Fisher's exact test. The study involved 11 patients in each concomitant ACL and MCL injury cases and healthy control groups with a mean age of 32.4 and 28 years, respectively. None of the patients reported knee instability symptoms in the 2-year follow-up. More than half of the patients continued their sports field without reinjury, with no significant difference in activity levels between case and control groups. The 6-meter hop test and single-leg hop test showed no significant difference between case and control groups (p-value: 0.326, 0.859), and no significant difference was observed in the three Carioca, cocontraction, and Shuttle tests in the 2-year follow-up. Functional tests in ACL and MCL injuries revealed normal outcomes, implying a nonsurgical approach for patients with proximal ACL tears, better knee stability, and no significant differences between the injured and control groups.
PDE10A Mutation as an Emerging Cause of Childhood-Onset Hyperkinetic Movement Disorders: A Review of All Published Cases
Authors: Kalampokini Stefania , Xiromerisiou Georgia , Bargiotas Panagiotis , Anastasiadou Violetta Christophidou , Costeas Paul , Hadjigeorgiou Georgios M.
Published: March 2024

Cyclic nucleotide phosphodiesterase (PDE) enzymes catalyze the breakdown of cyclic adenosine monophosphate (cAMP) and cyclic guanosine monophosphate (cGMP), which act as intracellular second messengers for signal transduction pathways and modulate various processes in the central nervous system. Recent discoveries that mutations in genes encoding different PDEs, including PDE10A, are responsible for rare forms of chorea in children led to the recognition of an emerging role of PDEs in the field of pediatric movement disorders. A comprehensive literature review of all reported cases of PDE10A mutations in PubMed and Web of Science was performed in English. We included eight studies, describing 31 patients harboring a PDE10A mutation and exhibiting a hyperkinetic movement disorder with onset in infancy or childhood. Mutations in both GAF-A, GAF-B regulatory domains and outside the GAF domains of the PDE10A gene have been reported to cause hyperkinetic movement disorders. In general, patients with homozygous mutations in either GAF-A domain of PDE10A present with a more severe phenotype and at an earlier age but without any extensive abnormalities of the striata compared with patients with dominant variants in GAF-B domain, indicating that dominant and recessive mutations have different pathogenic mechanisms. PDE10A plays a key role in regulating control of striato-cortical movement. Comprehension of the molecular mechanisms within the cAMP and cGMP signaling systems caused by PDE10A mutations may inform novel therapeutic strategies that could alleviate symptoms in young patients affected by these rare movement disorders.