bluuebunny/crossref_metadata_2025 huggingface dataset:
Physiological Effects of Alloxan on Serum Glucose Levels and Liver Function Test in Male Rabbit
Authors: Pirzada Iftikhar Ahmed , Kachiwal Allah Bux , Soomro Jameela , Buriro Rhahana S
Published: August 2024

Diabetes is a metabolic disorder characterized by elevated blood glucose levels that can lead to various complications. Exploring the physiological alterations in rabbits can provide valuable insights for the development of therapeutic interventions. This research delves into the impact of diabetes on the physiological and biochemical parameters of male rabbits. Objectives: To compare the physiological parameters like body temperature, heart rate, respiration rate, and oxygen saturation) and body weight and biochemical parameters, including blood glucose levels, alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, lactate dehydrogenase (LDH), and total protein levels in diabetic and non-diabetic rabbits. Methods: An experiment on 30 male rabbits divided into diabetic and control groups measured physiological parameters like body temperature, heart rate, respiration rate, and oxygen saturation. Body weight and blood glucose levels were tracked, and blood samples were taken for ALT, AST, creatinine, LDH, cholesterol, triglycerides and total protein levels. Statistical analysis was conducted to compare the physiological and biochemical parameters between the diabetic and control groups. Results: The results showed that induced diabetes in male rabbits affects their physiological and biochemical parameters significantly. Diabetic rabbits had lower body temperature, heart rate, respiration rate, and oxygen saturation compared to the control group. They also had higher body weight and blood glucose levels. Biochemical analysis showed increased ALT, AST, and creatinine levels, and decreased LDH and total protein levels in diabetic rabbits. Conclusions: These results demonstrate the extensive impact of diabetes on rabbit physiology and biochemistry, offering insights for future diabetes research.
The Scope and Challenges of Medical Technology Allied Health Professionals in Pakistan
Authors: Shah Khadija , Ahmed Fahad , Nizar Ali Nazish , Rohilla Atiya Rahman
Published: August 2024

WHO and the US Department of Health and Human Services both define AHPs as healthcare professionals with specific connections to the art and science of healthcare, and expertise in therapeutic, diagnostic, and preventive interventions, showing leadership in clinical and technical proficiency. AHPs include dental hygienists, diagnostic medical sonographers, dieticians, medical technologists, occupational therapists, physical therapists, and speech-language pathologists. A growing number of AHPs in Pakistan are becoming stronger and more well-known in the healthcare system. The growing population and increased demand for health care professionals. In this modern era, where the country faces a brain drain of other known professions, increasing the demand for skilled AHPs who play a vital role in patient care, diagnosis, treatment, and rehabilitation. The increasing scope of AHPs is highlighted by factors such as public awareness of preventive and rehabilitative healthcare, government initiatives supporting workforce development, and the growth of academic institutions providing AH sciences programs. On March 5, 2022, the Pakistan AHPC was established to strengthen the unified professional body on a single platform. AHPs in Pakistan face challenges such as gaining formal recognition, enhancing education by implementing master's programs in all specialties, strategizing workforce planning, and boosting advocacy to empower the council in granting global acknowledgment to registered professionals. The AHPC is in its initial stages and must develop formal job descriptions for technicians and technologists, as well as establish pay scale recognition
Hormonal Therapy and Endometrial Cancer: Latest Advancements
Authors: Mehboob Riffat
Published: August 2024

Endometrial cancer ranks as the sixth most common malignancy among women worldwide and fourth most common cancer of female reproductive system, with an incidence rate that has increased by 132% over the last 30 years [1].  It is uterine cancer which develops in inner lining of uterus (endometrium). Common symptoms include abnormal uterine bleeding, pelvic pain, and an enlarged uterus.  The factors that have increased risk of getting endometrial cancer are obesity, diabetes, hypertension, menopause age, infertility, hormonal imbalance and polycystic ovary syndrome (PCOS). According to a report in 2023, it was projected that there would be over 66,000 new cases and more than 13,000 deaths attributed endometrial cancer in United States [2]. The high incidence and mortality rates are fueling growing concerns among women globally. The pathological mechanism involves invasion of stromal and myometrial tissues, often associated with Phosphatase and tensin homolog (PTEN) mutations, KRAS2 mutations, and microsatellite instability. Endometrial cancer has been categorized into type 1 and type 2 based on histological features.
Traditional methods for treatment of endometrial cancer (surgery, chemotherapy) are effective and essential but recent advancements in the field of endometrial oncology have raised hopes of people, particularly hormonal therapy is emerging as promising option for non-toxic treatment in type 1  (estrogen dependent) and recurrent endometrial cancer. Estrogen and progesterone work antagonistically and the endometrium, which is responsive to hormones, grows when exposed to estrogen and stops growing when exposed to progesterone during the menstrual cycle. The exposure to estrogen hormone for long time causes hormonal imbalance which increases thickness of uterus walls and provide site for cancerous cell growth.  As a result, hormone therapy uses progesterone to counter the effects of estrogen and decrease tumor growth. The success of hormone therapy relies on the existence of hormone receptors such as progesterone receptors (PRs) in cancer cells. Patients with grade 1 and 2 endometrial cancer undergo standard hormonal therapy which yields high response rates such as progestin and aromatase inhibitors. Tamoxifen is considered as second line hormonal agent due to low response rate. These medications play a key role in targeting specific hormonal pathways in endometrial carcinoma treatment and management. Hormonal therapies offer a favorable safety profile to manage recurrent tumors after chemotherapy.
As the landscape of hormonal therapy for endometrial cancer evolves rapidly, the integration of traditional hormonal treatment with targeted therapies represents a significant advance. Personalized medicine—understanding the distinctive hormonal characteristics of each tumor—will shape hormonal therapy for the future. Endometrial cancer research and clinical trials hold promise for developing more effective and less invasive treatments.
Comparative Study of the Combined Antibacterial Effects of Grape Seed and Cranberry Fruit Extracts on Extended-Spectrum Beta-Lactamase (ESBL)-Producing Escherichia coli
Authors: Bijarani Ali Nawaz , Sultana Ulfat , Iqbal Nasima , Naeem Nabeela , Irshad Sidra , Khadija Abbasi Momina
Published: August 2024

Antimicrobial resistance is a threat to global healthcare system. Therefore, there has been growing interest towards the natural plants which possess antimicrobial properties. Objective: The key goal of the current research is to find out the combined effect of cranberry fruit and grape seed extracts against Extended-Spectrum Beta-Lactamase (ESBL) Escherichia coli strains. Methods: E.coli bacteria with ESBL resistance were collected from the patient’s samples having bacterial infection. The extracts, grape seeds and cranberry fruits extract were prepared in different concentrations. Antibiotic susceptibility testing was done with different concentrations of the extracts, using agar dilution methods to assess their antibacterial efficacy against Meropenem and Linezolid. SPSS version 21.0 was used for data analysis. Results: The combined effect of cranberry fruit and grape seed extracts demonstrated significant antibacterial influence in counter to decrease ESBL E.coli strains. There were 40 specimens, with 45% female and 55% male, with an age range between 10 to 80 years old. Both the plant extract revealed high sensitivity against ESBL E.coli, with 95% sensitivity at the highest concentrations. The combination of CFE and GSE (50mg+60mg) showed more than 90% sensitivity, more than commonly used antibiotics like Meropenem and Linezolid. Conclusions: The combined effect of cranberry fruit and grape seed extracts showed excellent effect against antimicrobial resistance, particularly in ESBL-producing E.coli strains. The finding suggested the increase potential of natural products as alternative antimicrobial agents.
Tác động của toàn cầu hoá đến bất bình đẳng thu nhập: nghiên cứu thực nghiệm tại một số quốc gia Châu Á
Authors: Nguyễn Hồng Hạnh , Lâm Như Quỳnh
Published: August 2024

Nhiều tác động của toàn cầu hóa đã được các nhà nghiên cứu tìm hiểu qua nhiều thập kỷ, trong số đó có tác động của toàn cầu hóa tới bất bình đẳng thu nhập. Ảnh hưởng của toàn cầu hoá đối với sự bất bình đẳng thu nhập là một vấn đề đa chiều và phức tạp, đòi hỏi phải được nghiên cứu một cách kỹ lưỡng và toàn diện. Nghiên cứu tập trung đánh giá mức độ và xu hướng của bất bình đẳng thu nhập ở một số quốc gia Châu Á trong hai thập kỷ qua, dựa trên hệ số Gini cùng các chỉ số toàn cầu hóa thông qua 3 mô hình hồi quy đánh giá tác động của toàn cầu hoá thương mại, tài chính và công nghệ đến bất bình đẳng thu nhập. Kết quả nghiên cứu cho thấy toàn cầu hóa công nghệ góp phần vào việc thu hẹp khoảng cách thu nhập, trong khi toàn cầu hóa thương mại và tài chính làm gia tăng bất bình đẳng thu nhập ở các quốc gia châu Á được lựa chọn nghiên cứu.
Nghiên cứu về hành vi công dân của khách hàng trong môi trường thương mại điện tử: vai trò trung gian của sự cam kết mối quan hệ và niềm tin
Authors: Nguyễn Hoàng Giang , Lê Bảo Ngọc , Nguyễn Đắc Thành
Published: August 2024

Hành vi công dân của khách hàng đóng vai trò quan trọng trong việc duy trì và phát triển mối quan hệ giữa khách hàng và doanh nghiệp. Tuy nhiên, những nghiên cứu về hành vi công dân của khách hàng còn hạn chế. Dựa trên thuyết đáp ứng kích thích và lý thuyết sự cam kết - niềm tin, nghiên cứu này đánh giá các yếu tố ảnh hưởng tới hành vi công dân của người tiêu dùng trong môi trường thương mại điện tử thông qua vai trò trung gian của sự cam kết mối quan hệ và niềm tin. Kỹ thuật bình phương tối thiểu từng phần (PLS-SEM) được sử dụng để phân tích dữ liệu thu thập từ mẫu nghiên cứu gồm 287 người đã mua hàng trong môi trường thương mại điện tử. Kết quả cho thấy niềm tin, đặc quyền của khách hàng và sự cá nhân hóa ảnh hưởng tích cực tới sự cam kết. Đồng thời, chất lượng thông tin và tính năng an toàn có ảnh hưởng tích cực tới niềm tin. Vai trò trung gian của niềm tin và sự cam kết trong mối quan hệ với hành vi công dân cũng đã được khẳng định qua nghiên cứu này. Kết quả nghiên cứu gợi ra một số hàm ý cho các doanh nghiệp kinh doanh trong môi trường thương mại điện tử nhằm thúc đẩy hành vi công dân của người tiêu dùng.
Hành vi mua xanh nghiên cứu từ góc độ lý thuyết hành vi có kế hoạch mở rộng
Authors: Lê Anh Tuấn , Nguyễn Tố Tâm , Đặng Quốc Hưng , Trần Thị Hoàng Hà
Published: August 2024

Bài báo đề xuất mô hình TPB mở rộng kết hợp các yếu tố bản sắc, xúc cảm cũng như thói quen ảnh hưởng tới ý định và hành vi mua xanh của người tiêu dùng tại thị trường mới nổi là Việt Nam. Nghiên cứu cho thấy các yếu tố cơ bản của mô hình TPB vẫn khẳng định được vai trò trong mô hình nghiên cứu đề xuất. Bên cạnh đó các đóng góp quan trọng của nghiên cứu là khẳng định tác động mạnh mẽ của sự phấn khích tiêu dùng xanh tới ý định và hành vi mua xanh. Nghiên cứu này cũng khẳng định tác động tích cực của bản sắc tiêu dùng xanh tới hành vi mua xanh chưa được chỉ ra trong các nghiên cứu trước đây. Một đóng góp nữa của nghiên cứu là bên cạnh việc cho thấy thói quen mua hàng truyền thống không thực sự tác động tới ý định và hành vi mua xanh thì vẫn có tác động điều tiết tới việc chuyển đổi từ thái độ sang ý định và hành vi mua xanh.
Peningkatan Pemahaman Siswa Pada Pembelajaran Akidah Akhlak Melalui Model Pembelajaran Kooperatif Mind Mapping
Authors: Hasan Moch. Sya'roni , Rozaq Abd.
Published: August 2024

This study examines the implementation of the cooperative learning model, Mind Mapping, in enhancing students' understanding of the Akidah Akhlak subject in grade 10 science class 2 of MAN 6 Jombang. Employing a qualitative case study approach, this research involved 30 students and 5 Islamic Education teachers. Data was collected through participant observation, in-depth interviews, and document analysis. The results demonstrate that this learning model is effective in improving students' ability to interpret, conclude, and explain the material, as well as in addressing learning difficulties post-Distance Learning. The collaborative and visual aspects of this model contribute to increased student engagement and motivation, along with the development of non-academic skills. However, the research also identifies challenges in implementation, including differences in students' abilities and the need for more time. Although this model shows potential in integrating modern approaches with religious material, additional strategies are needed to develop students' higher-order thinking skills. This study concludes that the cooperative learning model, Mind Mapping, has significant potential in improving the quality of Akidah Akhlak learning, but requires further development for optimal implementation
Major considerations of nutrological therapy in cancer patients: a systematic review
Authors: Rocha Roger Rafael Porto , Caetano Tamara
Published: August 2024

Introduction: Oncological malnutrition is a highly prevalent comorbidity in cancer, limiting patients' quality of life. International and national clinical guidelines recommend supportive nutrition and exercise therapy for cancer patients. Objective: It was to present the main approaches to nutritional therapy in cancer patients. Methods: The present study followed a concise systematic review model (PRISMA). The literary search process was carried out from August to October 2023 and developed based on Web of Science, Scopus, PubMed, Science Direct, Scielo, and Google Scholar, using scientific articles from 2002 to 2023. The low quality of the evidence was attributed to case reports, editorials, and brief communications, according to the GRADE instrument. Results and Conclusion: A total of 81 studies were found that were subjected to eligibility analysis and, subsequently, 16 of the 22 final studies were selected. Most studies showed homogeneity in their results, with X2 =78.4% >50%. Current dietary guidelines for cancer patients fail to address adequate dietary intake of macro- and micronutrients that can improve patients' nutritional status. Clinical studies and meta-analyses have shown that there is an important impact of a personalized and specific diet on patients during and after anti-neoplastic treatment. Most studies indicate that cancer patients should receive a nutritional assessment immediately after diagnosis. You need to maintain a healthy body weight, with a body mass index of 20–24.9, preserving your lean mass and avoiding an increase in fat mass. Therefore, after diagnosing nutritional status, a conservative energy restriction of 500-1,000 kcal/day should be considered. Nutritional therapy should be based on the patient's nutritional status, eating habits, schedule, activities, and cultural preferences. Therefore, adequate dietary consumption of dietary macro and micronutrients rich in β-carotene and vitamins A, E, and C can prevent the deterioration of nutritional status, also improving the quality of life of cancer patients.
Microbial metagenomics and the personalized treatment of periodontal disease
Authors: Eissa Mostafa
Published: August 2024

This review explores periodontal disease, a chronic inflammatory condition affecting the gum tissues and supporting bone. It highlights the concerning prevalence of this disease, impacting nearly 1 billion adults globally, and emphasizes its association with various systemic health issues. Following a detailed description of the disease progression from gingivitis to periodontitis, the review examines traditional methods of diagnosis and treatment. These methods, including clinical examination, X-rays, scaling and root planning, and antibiotics, are effective but often employ a one-size-fits-all approach. The limitations of this approach in addressing the underlying cause, the specific bacterial communities within the oral microbiome, are discussed. Finally, the review introduces the concept of microbial metagenomics as a promising avenue for personalized diagnosis and treatment of periodontal disease. This technology analyzes the complete genetic fingerprint of the oral microbiome, paving the way for targeted interventions and potentially revolutionizing the future of periodontal care. Nevertheless, this advancement of the unique technologies does not come without its own challenges that include high cost which is an obstacle for poor countries, standardization requirements and ethical issues concerning the personalized medicine approach.
CISCO vs Other Networking Tools: A Comprehensive Study on Current Network Simulators and Categorizing Them Based on Their Performances
Authors: Ehigbochie David , Omoze Edirin
Published: August 2024

Abstract-Choosing the right simulator for a network project is a crucial aspect that cannot be ignored. Many network practitioners have faced the consequences of choosing an inadequate and low-performance simulator, leading to project failures and abandonment. Various studies have been conducted to compare different network simulators, but unfortunately, the importance of Cisco specialized network simulators has been overlooked. Cisco specialised network simulators play a significant role in the simulation of networks, and it is essential to include them in any comparative study. Therefore, the objective of this study is to compare relevant simulators with Cisco specialized simulators, using an evaluation method that considers eight key performance indicators, including scalability, ease to code, compatibility, license, graphical user interface support, routing protocol, pros and cons. The results of this study indicate that Cisco specialised simulators are an excellent choice for enhancing the performance and outcomes of network simulators. Therefore, it is highly recommended that network practitioners and researchers consider Cisco network simulators when comparing simulators for their projects to ensure optimal results.
Positive Transfer of Third Language Acquisition in English and French Sentence Patterns
Authors: He Xiaomin
Published: August 2024

Language takes sentences as the basic unit and sentence structures in different languages have their own characteristics. At present, with the in-depth development of economic globalization and the rapid enhancement of the demand for cross language communication, there are more and more trilingual users. Therefore, third language acquisition, as an emerging field of international and domestic research in recent years, has attracted extensive attention. As is known to all, the two languages, English and French, are closely related but different. Hence, in the process of learning French as a second foreign language, the positive and negative transfer of English to French is inevitable. Under the framework of third language acquisition and based on language transfer theory, this paper analyzes the positive transfer of sentence structure in the process of third language acquisition through the comparative analysis of four special sentence patterns in English and French, which is helpful for English majors to learn French as a second foreign language more concisely and efficiently.
Pengaruh komite audit, financial distress dan komisaris independen terhadap integritas laporan keuangan dengan whistleblowing sebagai pemoderasi
Authors: Handayani Firli Dwi , Annisa Dea
Published: August 2024

This research aims to examine the effect of the audit committee, financial distress, and independent commissioners, with whistleblowing as a moderating variable, on the integrity of financial statements in the consumer non-cyclicals sector companies listed on the Indonesia Stock Exchange (IDX) from 2020 to 2022. This study uses a quantitative approach and employs an associative method. The type of data used in this research is secondary data. Panel data regression is used as the research methodology. The analysis of the research results utilizes E-views 12 and Microsoft Excel software. The population in this study comprises companies in the consumer non-cyclicals sector listed on the IDX during the 2020-2022 period. The sample used in this study consists of 79 companies in the consumer non-cyclicals sector during the 2020-2022 period. The results of the research indicate that statistically, financial distress affects the integrity of financial statements, while the audit committee and independent commissioners do not affect the integrity of financial statements. The research results also show that statistically, whistleblowing can moderate the influence of the audit committee and independent commissioners on the integrity of financial statements. However, whistleblowing cannot statistically moderate the effect of financial distress on the integrity of financial statements.
 Penelitian ini bertujuan untuk menguji apakah pengaruh komite audit, financial distress dan komisaris independen dengan whistleblowing sebagai variabel moderasi berpengaruh terhadap integritas laporan keuangan pada perusahaan sektor consumer non cyclicals yang terdafatar di Bursa Efek Indonesia (BEI) pada tahun 2020 – 2022. Penelitian ini menggunakan pendekatan kuantitatif dan menggunakan metode asosiatif. Jenis data yang digunakan dalam penelitian ini adalah data sekunder. Metode regresi data panel digunakan sebagai metodelogi penelitian pada penelitian ini. Analisa hasil penelitian menggunakan bantuan perangkat lunak E-views 12 dan Microsoft Excel. Populasi yang digunakan pada penelitian ini yaitu perusahaan sektor consumer non cyclicals yang terdaftar di Bursa Efek Indonesia (BEI) selama periode tahun 2020 – 2022. Sampel yang digunakan dalam penelitian ini sebanyak 79 perusahaan sektor consumer non cyclicals selama periode tahun 2020 – 2022. Hasil penelitian menunjukan bahwa secara statistik financial distress berpengaruh terhadap integritas laporan keuangan, sedangkan komite audit dan komisaris independen tidak berpengaruh terhadap integritas laporan keuangan. Hasil penelitian menunjukan secara statistik whistleblowing mampu memoderasi pengaruh komite audit dan komisaris independen terhadap integritas laporan keuangan. Dan secara statistik whistleblowing tidak mampu memoderasi pengaruh financial distress terhadap integritas laporan keuangan.
Strengthening Security: Implementation of Multi-Factor Authentication (MFA) in Data Center Environment
Authors:   Solution Architect, DXC Technology Building # 4, Mindspace IT Park, Madhapur, Hyderabad, Telangana 500081, India, Nanduri Vijaya Saradhi
Published: August 2024

Today's digital landscape needs robust security measures to safeguard sensitive information and maintain trust with users. Multi-Factor Authentication (MFA) stands as a critical technology in this journey, by offering an additional layer of defense beyond the traditional single-layer security. This white paper explores what is MFA, MFA Architecture, MFA Methods, Benefits of using MFA, current MFA Market providers and future trends. It outlines how MFA addresses the vulnerabilities of single-factor authentication by requiring users to verify their identity through multiple independent credentials. These factors typically include something the user knows (like a password), something they have (such as a smartphone or hardware token), and something they are (like biometric data). This white paper addresses key aspects of MFA as mentioned below: • Enhanced Security - MFA significantly reduces the risk of unauthorized access, protecting against common threats such as phishing, credential theft, and brute-force attacks. • User Experience - The MFA solution can be designed to streamline user interactions while maintaining security standards. Compliance requirements - Industries mandate the use of MFA to comply with data protection regulations. Implementing MFA ensures adherence to legal requirements.. Key Words: Authentication, Multi-Factor Authentication, security journals
Evaluating the Fasting Effect on the Level of Heavy Metals and Electrolyte Elements for Iraqi People in Ramadan
Authors: Abdulla Wasan Lafta , Abd Suha Talal , Shamkhy Eman Turky , Jebur Aseel Adel , Ramakrishnan Mahesh
Published: August 2024

In most healthy individuals, intermittent fasting during Ramadan, which occurs just once a year, could have positive effects on metabolic consequences. That even though there are several exceptions to fasting, many Muslims who have medical issues choose to fast. This may have a significant influence on their health if not addressed properly. The health consequences of Ramadan fasting have recently sparked renewed study.  This study is designed to evaluate the effect of fasting in Ramadan on the level of some metals and minerals compare these levels with a control group that is not fasting during Ramadan and show the effect of Ramadan on the health of fasting people. It was a study consisting of two categories.  The first group was composed of 50 people (males and females) who fasted during Ramadan, while the second group was composed of 50 people who ate and drank during Ramadan. From both groups tacked 5 ml of venous blood to estimate the concentration of metals which include: cadmium (Cd), lead (Pb), copper (Cu), zinc (Zn), calcium (Ca), chromium (Cr), magnesium (Mg),   potassium(K) and sodium (Na) during Ramadan month. The present study found that the concentration of cadmium, lead, copper and magnesium increase significantly in fasting group as compared to control group (with p- value =0.001 for Cd and p= 0.000 for other). whereas no significant difference in concentration of calcium, sodium and potassium between the fasting and control group. The results showed that fasting in Ramadan not affect the level of calcium, sodium and potassium, whereas the levels of cadmium, lead, copper, magnesium and chromium were affected, since they increased during fasting except chromium decreased. However, observing healthy food guidelines while fasting throughout Ramadan can lessen these alterations.
A review of recent developments in pharmaceutical chemistry on biological evolution of tetrazole derivatives
Authors: Ketan Zahraa A. , Ibrahim Halah A. R. , Slma Dhuha K. , Satar Hind A. , JAWAD ASMAA A.
Published: August 2024

This review sums up the developments in the biological activity of tetrazole active derivatives in recent days. Some of the deliberated derivatives of tetrazole are at present actively scientifically studied; some of them have biological activity that enables them to be studied further in the future as a drug for various biological activities. This review seeks to offer a comprehensive analysis of the efficacy and clinical advantage of biological activity for tetrazole derivatives.
Strengthening Social Cohesion in the Nineveh Plains of Iraq: Issues of Common Concern and Local Cooperative Solutions
Authors: Bourhrous Amal , Poignant Khafagi Emelie , Tartir Alaa
Published: August 2024

When the Islamic State was in control of the Nineveh Plains of Iraq between 2014 and 2017, it sought to destroy the region’s cultural diversity by targeting ethnic and religious communities and their ways of life. This has severely undermined social cohesion in the region. Mending intercommunity relations is therefore a peacebuilding priority. For peacebuilding to be sustainable, however, the engagement of community members is crucial. This SIPRI Research Policy Paper highlights some of the issues of common concern to communities in the Nineveh Plains and presents local cooperative solutions proposed by community members during intercommunity dialogue meetings. With adequate support from the relevant national and international actors, they offer opportunities for inclusive peacebuilding driven and owned by local communities and anchored in their everyday life.
Adverse Drug Reaction Monitoring and Assessment in Clinical Settings
Authors: Mir Mashooq Ahmad , Dar Mohd Altaf , Qadir Afshana , Qadrie Zulfkar , Ashraf Humaira
Published: August 2024

Implementing a structured Adverse Drug Reaction monitoring program is an effective method to proactively identify ADRs, hence enhancing the standard of patient care. The evaluation and monitoring of the safety of medications in clinical use are crucial for mitigating harm to patients and enhancing public health. In a clinical setting, this means establishing a highly structured Pharmacovigilance system. Pharmacovigilance is a crucial practice for monitoring drug-related concerns that arise after a medicine has been marketed and used in real-world settings. Pharmacovigilance and all matters concerning drugs are significant for those whose lives are affected in any kind by medical interventions. Adverse drug reactions (ADRs) significantly affect public health by diminishing patients' quality of life and imposing a substantial financial burden on healthcare systems, particularly during periods of financial crisis. Every healthcare provider has responsibilities in ensuring a harmonious equilibrium between the advantages and drawbacks of a medication. After a drug becomes accessible to the general public, assessing its safety becomes a collective duty of everyone involved in the process of prescribing, which includes patients as well. Healthcare workers play a crucial role in documenting and reporting suspected adverse drug reactions (ADRs).
Use of Android-Based E-Modules for Statistical Thinking Abilities
Authors: SARDIN Sardin , BAP Martadiputra , PRATAMA Andika
Published: August 2024

Developing statistical thinking skills is an important need in the industrial era 4.0 and society 5.0. Where the availability and openness of data is not limited by space and time. Statistical thinking is very important to help students focus so they can consume educated and accurate information. Statistical thinking is a way of understanding the complex world by describing it in relatively simple terms. This research aims to improve students' Statistical Thinking abilities by using Android application-based learning media. The method used in this research uses the literature study method. Data collection was carried out through literature reviews from several relevant studies, then continued with content analysis. The results of this research show that in general the use of Android-based E-Modules can improve statistical thinking abilities. The use of Androidbased E-modules also increases students' learning activities to become more active during the learning process. Apart from that, another positive impact is the acceleration and improvement of students' mathematics skills. The mobile characteristics of Android applications provide opportunities for students to re-study material they have not mastered anywhere and at any time.
Investigation of Oxidative Stress Parameters and Pro-Inflammatory Cytokines in a Neuropathy Model Created with Taraxacum Officinale L. Leaf Extract and Cisplatin
Authors: ERDEM Mehmet , ÖZASLAN Mehmet
Published: August 2024

The aim of this study was to investigate the effect of Taraxacum officinale leaf extract, a plant known for its potent antioxidant and anti-inflammatory properties, on cisplatin-induced neurotoxicity. Cancer treatment has demonstrated platinum drugs, particularly cisplatin, as among the most effective treatments. However, the drug comes with serious side effects. The use of cisplatin is limited due to its cytotoxic effects, potentially preventing patients from benefiting optimally from anticancer agents. Taraxacum officinale has been used for various diseases for years, observed clinically in conditions such as dyspepsia, liver, gallbladder, and urinary disorders. Nowadays, Taraxacum officinale has entered our lives in various forms as a dietary supplement. However, this plant possesses many bioactivities, particularly potent anti-inflammatory, antioxidant, and hepatoprotective properties.In this study, chronic cisplatin administration was used to induce a peripheral neuropathy model, administered intraperitoneally (i.p) once a week for 5 weeks at a dose of 3 mg/kg. Taraxacum officinale leaf extract was administered intragastrically once daily at a dose of 500mg/kg for the same duration to determine its potential effects on cisplatin neuropathy. After drug administration, motor performance was evaluated using the rotarod test, while sensory transmission status was assessed using tail withdrawal and hot/cold plate tests. Oxidative stress parameters and proinflammatory cytokine markers were analyzed biochemically. In animals exposed to cisplatin, thermal hypoalgesia and cold hypoalgesia were observed (p<0.001), motor coordination balance was prolonged with the rotarod test (p<0.001), and tail withdrawal time was extended (p<0.001). Biochemically, oxidative stress parameters TOS (p<0.05), OSI (p<0.05), and MDA (p<0.05) levels significantly increased compared to the cisplatin control group. TAS levels provided a statistically significant increase compared to the cisplatin-administered group (p<0.05). Proinflammatory cytokine markers TNF-α (p<0.05), IL-6 (p<0.001), and NFKB (p<0.05) levels were found to be higher compared to the cisplatin control group. It was determined that Taraxacum officinale improved these side effects induced by cisplatin both behaviorally and biochemically. In conclusion, Taraxacum officinale leaf extract is a plant with potent antioxidant and anti-inflammatory activity.
Decomposition of Hydrogen Peroxide in Presence of DimethylglyoximatoNickel Complexes as Catalysts: Catalase-Like Activity
Authors: KICHOU Noura , GUECHTOULI Nabila , MERRAD Anissa , HANK Zakia
Published: August 2024

The development in coordination chemistry in recent years raise hopes that synthetically produced metal complexes could mimic many biochemical systems widely found in nature. There is a certain analogy between nature and organometallic systems. A large number of biological metal complexes are known, including oxygen carriers like hemoglobin in the blood, which contains a ferrous ion; respiratory enzymes; those involved in protein hydrolysis; and vitamin B12, which is only active in the presence of cobalt in the trivalent state. The Nickel (III), in addition to Fe-S clusters, was an essential component in hydrogenases. Since then, nickel (III) complexes have been used as models for studying the catalytic function of certain enzymes (hydrogenases). In this context, a study on the catalytic ability of dimethylglyoximato-nickel complexes as peroxiredoxases in the dismutation or oxidation of hydrogen peroxide was conducted. The results were discussed, commented upon, and a reaction mechanism was proposed. The results seem encouraging, regarding the effect of the complexation on catalase- like activity.
Design and Calculation of Products from Composite Materials Using Software
Authors: SREBRENKOSKA Sara , SREBRENKOSKA Vineta , CEKEROVSKA Marija , CEKEROVSKI Todor
Published: August 2024

This article analyzes six types of composite pipes that are good replacements for corrosive steel and metal pipes for oil, gas, and water. The analysis of the six samples of composite pipes was done using the software program Hoffman Engineering, which is intended for the design and calculation of various types of products made of composite materials. For the analysis of the six composite pipes, the same diameter and the same length were taken, and variable parameters are: the type of material from which the composite pipes are made (carbon/epoxy, carbon-glass/epoxy and glass/epoxy), and the angle of winding of the fibers (10º and 90º degrees). Using the Hoffman Engineering software package, an analysis of the durability of the six differently designed composite pipes at high internal pressure was performed. The same conclusion was obtained from all analyses: the high internal pressure resistance of composite pipes is highly dependent on the fiber winding angle and the type of fibers used. Composite pipes obtained with a fiber winding angle of 90º have twice the internal pressure resistance compared to composite pipes obtained with a fiber winding angle of 10º. Composite pipes based on carbon fibers have the highest resistance to internal pressure, then composite pipes based on hybrid materials (glass and carbon fibers) and finally composite pipes based on glass fibers. Finally, a comparison was made with the obtained laboratory results for the same composite pipes. The same conclusion was obtained from all analyses: the high internal pressure resistance of composite pipes is highly dependent on the fiber winding angle and the type of fibers used. The composite pipes obtained by this process are durable and resistant to very high pressures.
Analysis of a High-Pressure Reciprocating Compressor Piston's 2D Simulation Utilizing Computational Fluid Dynamics
Authors: TURGUT Furkan , SIMSEK Ahmet Berkay , UNER Necip Berker , ERDOGAN Bariş
Published: August 2024

Reciprocating compressors represent the most renowned and extensively utilized compressors within the positive displacement category. A compressor that takes input gas at pressures above atmospheric and delivers it very high pressures (> 100 bar) is specifically called a booster pump. These pumps commonly consist of two or more piston-cylinder units in series, connected through check valves that determine the final delivery pressure, and they are instrumental in a range of applications centered around the storage and delivery of gases and fuels. Despite the availability of various booster pumps in the global market, literature offers limited insights into their design specifics. The design intricacies of a booster pump, tailored to operate at specified output pressure and mass flow rate, are contingent upon the interplay of coupled flow dynamics and heat transfer phenomena within the system. These phenomena include fluid flow dynamics through check valves, heat transfer across cylinder walls, and mechanical properties of pump materials, alongside cyclic operational parameters. To address this gap, we have embarked on an experimental-computational investigation aimed at elucidating the transport processes occurring in a single-cylinder booster pump. This work focuses on computational investigations concerning gas compression and the actuation of check valves in a single-cylinder reciprocating booster. Momentum and energy conservation equations were solved on a dynamic mesh platform through Ansys Fluent. Adiabatic conditions were employed, and the numerical solver was partially validated by comparison with thermodynamic theory for simulations conducted in a closed adiabatic cylinder. Calculations were then extended for an open cylinder with inlet and outlet check valves. Simulations indicate that forced cooling plays an important role for the longevity of sealing parts.
General Upper Bounds for the Numerical Radii of Hilbert Space Operators
Authors: AL- DOLAT Mohammed
Published: August 2024

We present a collection upper bounds for the numerical radii of a certain 2 × 2 operator matrices. We use these bounds to improve on some known numerical radius inequalities for powers of Hilbert space operators. In particular, we show that if 𝐴 is a bounded linear operator on a complex Hilbert space, then 𝑤 2𝑟 (𝐴) ≤ 1+𝛼 8 ‖|𝐴| 2𝑟 +|𝐴 ∗ | 2𝑟‖+ 1+𝛼 4 𝑤(|𝐴| 𝑟 |𝐴 ∗ | 𝑟 )+ 1−𝛼 2 𝑤 𝑟 (𝐴 2 ) for every r ≥ 1 and α ∈ [0,1]. This substantially improves on the existing inequality 𝑤 2𝑟 (𝐴) ≤ 1 2 ‖|𝐴| 2𝑟 + |𝐴 ∗ | 2𝑟‖. Here 𝑤(. ) and ||. || denote the numerical radius and the usual operator norm, respectively.
Integration of Air Conditioning Systems in Intelligent Buildings to Increase Efficiency
Authors: BUNDO Jonadri , SHARKO Genci , SPAHIU Aida , ALUSHAJ Ramadan , PANXHI Denis , DHAMO Darjon
Published: August 2024

Heating, ventilation, air conditioning, and cooling, collectively known as HVAC, account for more than 40% of the electricity consumed in buildings. Global climatic factors, referring to comfort and factors related to health, dictate that there is an increasing need for the application of HVAC/R systems. Therefore, it is increasingly compelling to investigate various approaches to enhance the effectiveness of air treatment systems. The automation of buildings has facilitated the integration of air treatment systems with “other existing” systems that can impact the indoor climatic conditions, such as automated windows and curtains, etc. In order to achieve this, it is essential to employ calculation techniques for air handling systems and for the heat transfer between buildings and the external environment. By integrating these systems, it becomes possible to maintain a comfortable environment while actively minimizing the electricity consumption of the heat pump. This article focuses on the integration of air conditioning systems in intelligent buildings to enhance efficiency.
Proposed Intelligent Irrigation System for Riyadh City Using Fuzzy Logic
Authors: ALSAADOUN Sara , TCHIER Fairouz
Published: August 2024

Considering the insufficient rainfall and rapid evaporation of soil moisture in desert regions, irrigation becomes very challenging in Riyadh. Automation is therefore required for optimum productivity and water conservation. According to the vision of the Green Riyadh project, recycled water will be used in the irrigation system to irrigate all green lands. The method of irrigation and the quantity of water being used must both be considered. Since drought inhibits plant growth and excessive moisture limits plants' ability to absorb nutrients and raises the possibility of disease development, only the amount of water needed by plants should be used. Artificial intelligence and fuzzy logic are increasingly seen as solutions to be implemented in smart drip irrigation systems. The fuzzy logic control system will aid in water conservation given its shortage, which has become a major worldwide concern. The system also has the advantage of conserving moisture to counteract inadequate rainfall, saving electricity and reducing labor costs. For such advantages, an intelligent irrigation control system based on fuzzy logic adapted to the climate of Riyadh will be proposed. Based on the measured soil moisture, ambient temperature, air humidity and solar irradiance, the fuzzy controller calculates the necessary irrigation duration. The features of the fuzzy logic toolbox in MATLAB are used to create the proposed system.
Possibilities for Improving Algorithms for Combat Use of Aircraft Using Unguided Weapons
Authors: ATANASOV Milen
Published: August 2024

Combat actions in recent local conflicts make us consider and re-evaluate some of the concepts concerning the development of combat aviation. As it turns out, conducting combat operations at high intensity for a long period of time using all components of the armed forces shows that the use of high-tech aircraft is extremely expensive and requires a large period of time to bring them back to full operational readiness when damage has been inflicted on them during hostilities. This is evidenced by the limited use of 5th generation aircraft in local conflicts. They are mainly used at long distances and with a tangible technological superiority over the enemy. Also, the sustained use of high precision guided weapons proves to be extremely expensive. All this makes us think and apply a creative approach to finding a solution to these problems. One of these approaches is through the improvement or rather the modernization of existing combat platforms through the implementation of advanced mathematical models and algorithms for combat use, which will increase the accuracy and efficiency of the use of unguided weapons, which are significantly cheaper compared to using guided ones. As the accuracy of using unguided weapons increases, it approaches that of guided ones. This is very important in the conduct of prolonged intensive combat operations in the conditions of limited resources. On the other hand, the use of advanced algorithms for combat use will simplify and facilitate the pilot's work with the controls of the aviation armament during the execution of combat tasks.A general mathematical model and a general algorithm for the combat use of aircraft weapons are proposed. A general mathematical model was developed for solving the ballistic task for large groups of guided and unguided weapons, which is a component of the general algorithm for combat use.
Physicochemical, Morphological and Anticorrosive Properties of Electrodeposited ZnNi Alloy Coating
Authors: BENFEDDA Baya , BOUDINAR Salem , MEZINE Zaina
Published: August 2024

Corrosion in its many forms is a major problem for many types of materials, extending from machining to manufacturing and daily use. In fact, it affects practically all engineering projects, from the biggest to the smallest: energy production, construction, transport, medical sector, electronics, etc. Consequently, corrosion generates both economic and environmental problems. To prevent corrosion and preserve materials' durability, several protection methods can be applied. These included protection by applying a coating on the metal surface. In this context, Zinc based alloy coatings have attracted much interesting scientific community because of their excellent mechanical and anti-corrosive properties. In the present work, ZnNi coatings were electrodeposited on steel substrates using a chloride bath containing ammonium salts. The effect of some experimental parameters, namely, potential and metal ion concentration ratio on the deposition kinetics of ZnNi system as well as on its physicochemical, morphological and anticorrosive properties has been investigated. For this purpose, an appropriate experimental work was performed by using both electrochemical (cyclic voltammetry, chronoamperometry, open circuit potential, potentiodynamic polarization) and nonelectrochemical (SEM-EDX) analysis methods. Based on the obtained results, it has been revealed that simultaneous codeposition of both elements Zn and Ni is possible in our experimental conditions. However, deposition kinetics exhibited a strong dependence on explored parameters. Also, morphological aspect and chemical composition of deposits are strongly influenced by metal ion concentration ratio. Investigation of corrosion behaviour confirms the protective effect of coatings acted as a sacrificial anode. Furthermore, increasing Ni content in the deposits induces a significant enhancement in corrosion resistance. Thus, Zn-Ni alloy coatings prepared from the Ni(II)-rich bath exhibited better corrosion resistance.