bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemical and Transcriptomic Analyses Provide New Insights into Key Genes for Ginsenoside Biosynthesis in the Rhizome of Panax japonicus C. A. Meyer
Authors: Yang Qichun , Xiong Chao , Zhang Jiao , Ming Yue , Zhang Shaopeng , Wang Limei , Wang Hongxun , Xu Ran , Wang Bo
Published: October 2024

Panax japonicus C. A. Meyer is renowned for its significant therapeutic effects and is commonly used worldwide. Its active ingredients, triterpenoid saponins, show variation in content among different tissues. The tissue-specific distribution of saponins is potentially related to the expression of vital genes in the biosynthesis pathway. In this study, the contents of five saponins (ginsenoside Ro, chikusetsusaponin IV, chikusetsusaponin IVa, ginsenoside Rg1, and ginsenoside Rb1) in three different tissues were determined by HPLC. Transcriptome sequencing analysis identified differentially expressed genes (DEGs) involved in triterpenoid saponin biosynthesis, highlighting significant correlations between saponin contents and the expression levels of 10 cytochrome p450 monooxygenase (CYP) and 3 UDP-glycosyltransferase (UGT) genes. Cloning, sequencing, and prokaryotic expression of UGT genes confirmed the molecular weights of UGT proteins. Gene sequence alignment and phylogenetic analysis provided preliminary insights into UGT gene functions. Meanwhile, the function of one UGT gene was characterized in the yeast. These findings advance our understanding of the triterpenoid saponin biosynthesis in P. japonicus and support future research in traditional Chinese medicine (TCM) and synthetic biology.
Mosaic of Meaning: A Redemptive Reading of Genesis 3:16 in Light of Its Biblical Contexts and Inter-Texts
Authors: Davidson Richard M.
Published: October 2024

This paper provides a fresh redemptive reading of Gen 3:16, viewed in light of a whole mosaic of canonical contexts and intertextual connections. These include, among others, the full equality without hierarchy of man and woman in Gen 1–2; the paradigmatic nature of egalitarian marriage with mutual submission between husband and wife in Gen 2:18–24; the rupture of husband–wife relationships in Gen 3:6–13; the covenant lawsuit of Gen 3:14–19; the meaning of mashal in Gen 1:16–18 and 4:7; the meaning of teshuqah and grammatical–syntactical parallels and contrasts in Gen 4:7 and Song 7:11 (Eng. v. 10); the redemptive aspects of the woman and her seed in Gen 3:15; and the intertextual connections with New Testament passages. Considering this mosaic of contexts and connections, it is suggested that Gen 3:16 must be viewed only in reference to marriage; it is never broadened to include man–woman gender relationships in general. In Gen 3:16, God provides a temporary, remedial measure to preserve harmony and unity in a ruptured marriage relationship, with an implicit call for husbands and wives to return as soon as possible from the mashal–teshuqah relationship to the paradigmatic egalitarian marriage set forth in Gen 2:24. This return to the divine creation ideal for marriage is empowered by the redemptive promises of Gen 3:15, confirmed in the reversal of the Gen 3:16 marital relationship articulated in the Song of Songs—the inspired commentary on Gen 1–3—particularly Song 7:11 [Eng. v. 10]), and reaffirmed in the consistent citations of Gen 2:24 (and not Gen 3:16) in the NT (Matt 19:5, 6; Eph 5:31).
The Changing Muslim World: Energy, Extraction, and the Racialization of Islam in Protestant Missions
Authors: Smith Matthew J.
Published: October 2024

This essay examines the role of Anglo Protestant missions in the Persian Gulf in racializing “the Moslem world” for the emergent white world order at the beginning of the 20th century. More specifically, I consider the way Protestant missionaries extracted knowledge about Islam, racializing “the Moslem world” as a civilizational “unit” devoid of energetic life—and therefore incompatible with the modern world—even as they simultaneously mediated the rise of oil extraction along the Persian Gulf in that same period. Extraction was not only evident in the material relations of empire, but also in the way Protestant missionary discourse shaped “the Muslim world” into a racial unit in need of management and optimization. I consider two energetic grammars used by Protestant missionaries to signify the changes occurring in “the Moslem World”, namely, Samuel Zwemer’s use of “disintegration” and Basil Mathews use of “ferment”. I argue that it was in these material and discursive entanglements of oil extraction where knowledge about Islam became an important tool of European colonial governance, and where energetic grammars of religion became critical to the biopolitical production and management of racialized Muslim populations.
Energy-Saving Multi-Agent Deep Reinforcement Learning Algorithm for Drone Routing Problem
Authors: Shu Xiulan , Lin Anping , Wen Xupeng
Published: October 2024

With the rapid advancement of drone technology, the efficient distribution of drones has garnered significant attention. Central to this discourse is the energy consumption of drones, a critical metric for assessing energy-efficient distribution strategies. Accordingly, this study delves into the energy consumption factors affecting drone distribution. A primary challenge in drone distribution lies in devising optimal, energy-efficient routes for drones. However, traditional routing algorithms, predominantly heuristic-based, exhibit certain limitations. These algorithms often rely on heuristic rules and expert knowledge, which can constrain their ability to escape local optima. Motivated by these shortcomings, we propose a novel multi-agent deep reinforcement learning algorithm that integrates a drone energy consumption model, namely EMADRL. The EMADRL algorithm first formulates the drone routing problem within a multi-agent reinforcement learning framework. It subsequently designs a strategy network model comprising multiple agent networks, tailored to address the node adjacency and masking complexities typical of multi-depot vehicle routing problem. Training utilizes strategy gradient algorithms and attention mechanisms. Furthermore, local and sampling search strategies are introduced to enhance solution quality. Extensive experimentation demonstrates that EMADRL consistently achieves high-quality solutions swiftly. A comparative analysis against contemporary algorithms reveals EMADRL’s superior energy efficiency, with average energy savings of 5.96% and maximum savings reaching 12.45%. Thus, this approach offers a promising new avenue for optimizing energy consumption in last-mile distribution scenarios.
Development of Dual-Arm Human Companion Robots That Can Dance
Authors: Kim Joonyoung , Kang Taewoong , Song Dongwoon , Ahn Gijae , Yi Seung-Joon
Published: October 2024

As gestures play an important role in human communication, there have been a number of service robots equipped with a pair of human-like arms for gesture-based human–robot interactions. However, the arms of most human companion robots are limited to slow and simple gestures due to the low maximum velocity of the arm actuators. In this work, we present the JF-2 robot, a mobile home service robot equipped with a pair of torque-controlled anthropomorphic arms. Thanks to the low inertia design of the arm, responsive Quasi-Direct Drive (QDD) actuators, and active compliant control of the joints, the robot can replicate fast human dance motions while being safe in the environment. In addition to the JF-2 robot, we also present the JF-mini robot, a scaled-down, low-cost version of the JF-2 robot mainly targeted for commercial use at kindergarten and childcare facilities. The suggested system is validated by performing three experiments, a safety test, teaching children how to dance along to the music, and bringing a requested item to a human subject.
Análise comparativa da força de adesão do cimento endodôntico CIMMO HP® pelo método de push-out
Authors: Souza Mário Gomes de , Serra Geidson de Souza Santos Jacinto , Araújo Kilvia Magalhães , Sousa Giliardo da Silva , Ferraz Maria Ângela Area Leão , Pinto Antonione Santos Bezerra , Falcão Carlos Alberto Monteiro
Published: October 2024

Introdução: A eficácia da terapia endodôntica é intrinsecamente ligada à qualidade da adesão entre os cimentos endodônticos e a dentina radicular. A busca por materiais que ofereçam uma adesão otimizada é fundamental para garantir resultados duradouros e bem-sucedidos. Objetivo: Analisar de forma comparativa a força de adesão do cimento biocerâmico CIMMO HP® em relação aos cimentos Bio-C Sealer e Sealer Plus BC, por meio do método de push-out. Material e Métodos: Foram utilizadas 30 raízes de incisivos centrais superiores, seccionadas em 60 secções axiais de 2 mm de espessura. Cada secção recebeu um orifício de 1,2 mm de diâmetro. As secções foram divididas aleatoriamente em três grupos (n= 20) correspondentes a cada tipo de cimento: Grupo 1 (CIMMO HP®), Grupo 2 (Bio-C Sealer) e Grupo 3 (Sealer Plus BC). Em seguida, os cimentos foram manipulados e aplicados nos orifícios, seguindo as instruções dos fabricantes. Os espécimes foram incubados a 37°C por 3 dias com umidade controlada e submetidos ao teste de push-out com velocidade de 1 mm/min. na máquina semi universal de ensaios. A análise estatística incluiu ANOVA e teste posterior de Tukey, considerando um valor de p <0,05 para determinar a significância das diferenças entre os grupos. Resultados: O cimento Sealer Plus BC apresentou a maior força de união (281,47±13,65 MPa), significativamente superior aos grupos Bio-C Sealer (0,00±13,65 MPa) e CIMMO HP® (-3,23±13,65 MPa), com p <0,001. Não houve diferença significativa entre Bio-C Sealer e CIMMO HP® (p= 0,970). Conclusão: Sob as condições experimentais testadas, o cimento CIMMO HP® apresentou uma força de adesão equivalente ao Bio-C Sealer e inferior quando comparado com o Sealer Plus BC.
Ocorrências policiais no interior de shoppings centers: planejamento e ação comunitária para atendimento primário
Authors: Freitas Giuliano de , Wosniak Hosana Marjory Rocella
Published: October 2024

O presente artigo aborda a atuação da Polícia Militar do Paraná (PMPR) em ocorrências no interior de shoppings centers, com foco nos desafios operacionais e na integração ao policiamento comunitário. O objetivo principal é fomentar estudos complementares que subsidiem a criação de Procedimentos Operacionais Padrão (POP) voltados ao primeiro atendimento. Especificamente, o estudo busca identificar os riscos envolvidos, analisar as estratégias de cooperação entre a polícia e a segurança privada, e avaliar a eficácia de abordagens discretas e planejadas. A metodologia utilizada foi baseada em um estudo de caso do Shopping São José, em São José dos Pinhais, analisando as intervenções da 1ª Companhia do 17º Batalhão da PMPR. O artigo explora como ações coordenadas podem minimizar pânico e garantir a segurança de civis e policiais. Os resultados indicam que uma intervenção padronizada pode melhorar a resposta policial em ambientes de grande circulação. A relevância deste estudo reside na contribuição para o aprimoramento da segurança pública, propondo caminhos para que a PMPR atue de forma mais eficiente e em cooperação com a segurança privada, beneficiando tanto a sociedade quanto a corporação.
Официальные издания Новгородской губернии: «Новгородские губернские ведомости» (1838–1918), «Новгородские епархиальные ведомости» (1875–1920): монография
Authors:   ОАУКИ «Новгородское областное театрально-концертное агентство», Козлов С. А. , Василенко И. В. ,   Новгородский государственный университет им. Ярослава Мудрого, Кавецкая О. С. ,   ООО «Торговый Дом «Эдельвейс», Семенова А. Л. ,   Новгородский государственный университет им. Ярослава Мудрого, Васильева Д. Н. ,   Новгородский государственный университет им. Ярослава Мудрого
Published: October 2024

Коллективная научная монография рассматривает становление и развитие официальной печати в Новгородской губернии. По указу Николая I в Российской империи была создана система губернских изданий, которые должны были выполнять информационно-административную функцию. Первое печатное периодическое издание – «Новгородские губернские ведомости». С 1875 года появились «Новгородские епархиальные ведомости», аудитория которых была уже, чем у губернских ведомостей, ограничиваясь конфессиональной принадлежностью. Но оба издания оказали большое влияние на местную публику, формируя традиции местной журналистики, осваивая различные темы местной жизни, используя различные жанровые формы. Книга будет востребована студентами, учителями, всеми, кто интересуется историей Новгородского края, кто исследует историю отечественной журналистики, в том числе провинциальную.
Genetic aspects of vulnerability to COVID-19 and their influence on individual susceptibility to severe disease in children
Authors: Burov A. , Bodnarchuk-Sokhatska N.
Published: October 2024

Despite the lower prevalence of COVID-19 (COronaVIrus Disease 2019) infection in children, such threatening conditions as severe SARS-CoV-2-associated pneumonia and Multisystem Inflammatory Syndrome in Children (MIS-C) pose a challenge in differential diagnosis, early hospitalization and treatment. Therefore, the purpose of the study was to investigate the genetic characteristics of children's susceptibility to the occurrence of severe COVID-19 and MIS-C, with the determination of predictors and risk factors. Genetic factors were evaluated on the basis of a literature search, and phenotypic manifestations were assessed on the basis of the analysis of medical documentation of 119 patients, who were treated in infectious departments with the diagnoses of COVID-19 (n=38), MIS-C (n=8), influenza (n=45), and acute viral respiratory infection (n=28). The results of the study revealed differential diagnostic criteria for severe forms of COVID-19 and MIS-C. Among COVID-19 symptoms, gastrointestinal manifestations prevailed, such as nausea, vomiting, diarrhea and abdominal pain. While rash, bilateral conjunctivitis, lymphadenopathy, gastrointestinal and cardiovascular disorders were chara­cteristic of MIS-C. Based on the analysis of genetic features, risk factors and co-morbidities that aggravate the course of covid infection have been determined in order to create algorithms for ambulatory supervision and dispensation of children from risk groups. Thus, children with asthma, diabetes, obesity, congenital immunodeficiencies and heart defects need dispensary supervision from the point of view of risk of severe COVID-19. Outpatient supervision for a month is required for practically healthy children who have had positive COVID-19 test or have been in contact with patients with COVID-19. The determination of blood laboratory parameters, electrocardiography and ultrasound of the abdominal organs should be performed for early diagnosis of MIS-C.

Keywords: multisystem inflammatory syndrome MIS-C, severe form of COVID-19, risk factors, genetic features, dispensation, diagnostic criteria.
Apicultura: Análisis de la gestión agroempresarial en Manabí, Ecuador
Authors: Alcívar Álava Ignacio Ausberto
Published: October 2024

La apicultura, más que una simple actividad agrícola, es una práctica esencial para la sostenibilidad ambiental y la economía local. Una gestión eficiente no solo optimiza los recursos y mejora la rentabilidad, sino que también garantiza la calidad de los productos y la sostenibilidad del ecosistema. El objetivo de la presente investigación es definir las características que configuran los modelos de gestión aplicados a esta actividad. A fin de alcanzarlo se realiza una investigación cualitativa con un enfoque exploratorio y descriptivo con la utilización de entrevistas, revisión documental y la observación de las prácticas de la apicultura en la provincia de Manabí y concluye con una propuesta de modelo de gestión agroempresarial aplicado a la apicultura.
GIẢI TRÌNH TỰ VÀ NGHIÊN CỨU ĐẶC ĐIỂM HỆ GEN LỤC LẠP CÂY MÙ U (CALOPHYLLUM INOPHYLLUM L.) Ở TỈNH TRÀ VINH
Authors: Huỳnh Đoàn Thiện Phúc  , Trương Thị Thanh Huyền  , Trần Thị Thu Hồng  , Đỗ Hoàng Đăng Khoa  , Nguyễn Nhật Nam
Published: October 2024

SEQUENCING AND CHARACTERIZING THE CHLOROPLAST GENOME OF Calophyllum inophyllum L. AND ITS POTENTIAL FOR SUSTAINABLE AGRICULTURAL DEVELOPMENT
Tóm tắt: Với giá trị thảo dược cao, nhiều sản phẩm được phát triển từ cây mù u như dầu mù u và các loại nguyên liệu mĩ phẩm. Tại tỉnh Trà Vinh, mô hình khai thác và phát triển nguồn gen cây mù u tại xã Mỹ Long Nam, huyện Cầu Ngang đang được triển khai thực hiện và cho thấy tiềm năng phát triển kinh tế. Thông tin hệ gen thực vật, đặc biệt hệ gen lục lạp, là cơ sở phát triển các ứng dụng trong lĩnh vực nông nghiệp như lai tạo giống, các nghiên cứu di truyền, và phát triển chỉ thị phân tử. Trong nghiên cứu này, kĩ thuật giải trình tự thế hệ mới được thực hiện để giải mã trình tự, thành phần gen và đặc điểm cấu trúc của bộ gen lục lạp cây mù u. Kết quả cho thấy, hệ gen lục lạp cây mù u (Calophyllum inophyllum L.) có kích thước là 161.169 bp. Hệ gen lục lạp bao gồm 79 gen mã hóa protein, 30 vùng mã hóa tRNA và bốn vùng mã hóa rRNA. Kết quả này cung cấp thông tin cơ bản cho các nghiên cứu bảo tồn, nghiên cứu đa dạng sinh học và các ứng dụng cơ sở di truyền của cây mù u cũng như các loài liên quan.
Abstract: Due to its high content of medicinal value, many products have been developed from the tamanu tree, such as tamanu oil and various cosmetic raw materials. In Tra Vinh province, a model for exploiting and conserving genetic resources of tamanu is conducted at My Long Nam Ward, Cau Ngang District, and shows potential for economic development. The Chloroplast genome is one of three genomes of plants that exhibit an important role in agriculture, such as breeding, genetic studies, and molecular marker development. In this study, next-generation sequencing technology was used to decode the sequence, gene composition, and structural characteristics of the chloroplast genome of the tamanu tree. Consequently, the complete chloroplast genome of the tamanu tree was 161,169 bp in length. This genome included 79 protein-coding genes, 30 tRNA genes, and four rRNA genes. The results of this study provide essential information for further studies about conservation, biodiversity, and genetic applications of tamanu trees and related species.
CHIẾT XUẤT CARBOHYDRATE TỔNG SỐ, VITAMIN C, β-CAROTENE VÀ LYCOPENE TRONG QUẢ BÍ ĐỎ (Cucurbita moschata D.) BẰNG SÓNG SIÊU ÂM
Authors: Lê Quốc Duy  , Vương Tuấn Phong
Published: October 2024

EXTRACTION OF TOTAL CARBOHYDRATES, VITAMIN C, Β-CAROTENE, AND LYCOPENE IN PUMPKIN (Cucurbita moschata D.) USING ULTRASOUND WAVES
Tóm tắt: Bí đỏ (Cucurbita moschata D.) là loại cây trồng thuộc họ bầu bí (Curbitaceae), được trồng nhiều nước trên thế giới và là một trong những loại rau ăn quả chứa nhiều dưỡng chất có lợi cho sức khoẻ con người. Hàm lượng carbohydrate tổng số, vitamin C, β-carotene và lycopene được xác định dựa vào đường chuẩn được thực hiện trên máy quang phổ UV-Vis. Kết quả li trích trong 100 g thịt quả tươi ở bí đỏ bằng sóng siêu âm với công suất 3000 W ở các tần số 20, 30, 40 và 50 kHz thu được carbohydrate tổng là 18,82 g/100 g ở tần số 50 kHz, bước sóng λ = 490 nm; hàm lượng vitamin C thu được 32,63 mg/100 g ở tần số 20 kHz, λ = 491 nm, trong khi đó hàm lượng β-carotene và lycopene đều cho hiệu suất trích li cao ở cùng tần số 40 kHz là 561,22 µg/100 g, 32,19 µg/100 g và λ = 450 nm, λ = 472 nm. Kết quả nghiên cứu cho thấy sử dụng sóng siêu âm phá vỡ vách tế bào trong quá trình trích li các hợp chất carbohydrate tổng số, vitamin C, β-carotene và lycopene trong quả bí đỏ cho hiệu suất thu hồi cao.
Abstract: Pumpkin (Cucurbita moschata D.) is a cultivated plant species belonging to the gourd family (Curbitaceae), grown in many countries around the world, and is one of the beneficial vegetable fruits containing many nutrients for human health. The total carbohydrate content, vitamin C, β-carotene, and lycopene levels were determined based on standard curves performed on a UV-Vis spectrophotometer. The results of extraction from 100 g of fresh fruit pulp in pumpkin using ultrasound waves with a power of 3000W at frequencies of 20, 30, 40, and 50 kHz yielded total carbohydrates of 18.82 g/100 g at a frequency of 50 kHz, wavelength λ=490 nm; the vitamin C content obtained was 32.63 mg/100 g at a frequency of 20 kHz, λ=491 nm, while the β-carotene and lycopene levels both showed high extraction efficiency at the same frequency of 40 kHz, with 561.22 µg/100 g, 32.19 µg/100 g respectively, and wavelengths λ=450 nm, λ=472 nm. The research results demonstrate that the use of ultrasound waves disrupts cell walls during the extraction process of total carbohydrates, vitamin C, β-carotene, and lycopene compounds in pumpkin fruits, achieving high recovery efficiency.
MÔ HÌNH TOÁN HỌC VÀ PHÂN TÍCH THỰC NGHIỆM SẤY NẤM ĐÔNG TRÙNG HẠ THẢO (Cordyceps militaris) LỚP MỎNG TRONG TỦ SẤY CHÂN KHÔNG
Authors: Nguyễn Đức Toàn  , Võ Minh Hoàng  , Nguyễn Võ Phong Phú
Published: October 2024

MATHEMATICAL MODELING AND EXPERIMENTAL ANALYSIS OF Cordyceps militaris THIN LAYER DRYING IN VACUUM DRYER
Tóm tắt: Mục tiêu nghiên cứu này là đánh giá động học sấy thoát ẩm và mô hình hóa toán học quá trình sấy khô đông trùng hạ thảo lớp mỏng thực hiện ở các nhiệt độ khác nhau trong tủ sấy chân không. Quá trình sấy khô đông trùng thực hiện ở các nhiệt độ: 50°C, 60°C và 70°C với áp suất chân không 13 mbar đến khối lượng mẫu đạt trạng thái cân bằng. Các giá trị tỉ lệ độ ẩm (Moisture Ratio) thử nghiệm ở mỗi nhiệt độ được mô phỏng theo mô hình toán học Lewis, Henderson and Pabis, và Page. Kết quả cho thấy mô hình Page có giá trị chi bình phương (χ2) trung bình, sai số bình phương trung bình (RMSE) nhỏ nhất, và giá trị hệ số xác định (R2) cao nhất (> 0,99). Vì vậy, mô hình Page mô tả tốt nhất đặc tính sấy chân không của mẫu đông trùng hạ thảo trong khoảng nhiệt độ 50oC÷70oC.
Abstract: The objective of this study is to evaluate the drying kinetics and mathematical modeling of the drying process of thin-layer Cordyceps militaris performed at different temperatures in a vacuum oven. The drying process is carried out at temperatures: 50°C, 60°C, and 70°C with a vacuum pressure of 13 mbar until the sample mass reaches equilibrium. The experimental moisture ratio (MR) values at each temperature were simulated according to the Lewis, Henderson, Pabis, and Page mathematical models. The results show that the Page model has the average chi-square (χ2) value, the smallest mean square error (RMSE), and the highest coefficient of determination (R2) value (> 0.99). The Page model best describes the vacuum drying characteristics of Cordyceps militaris samples within the 50oC÷70oC temperature range.
TỔNG QUAN VỀ TINH BỘT KHÁNG TIÊU HÓA VÀ PHƯƠNG PHÁP THU NHẬN
Authors: Hồ Thị Hảo  , Trần Thị Hương Thảo  , Nguyễn Kim Phụng
Published: October 2024

OVERVIEW OF RESISTANT STARCH AND ITS ACQUISITION METHODS
Tóm tắt: Tinh bột là một nguồn năng lượng quan trọng trong khẩu phần ăn của con người. Tinh bột kháng tiêu hóa (RS) là phần không thể tiêu hóa tại ruột non, được vi khuẩn phân hủy ở ruột kết, tạo thành axit béo chuỗi ngắn. Việc tiêu thụ tinh bột kháng tiêu hóa có tác động tích cực đến sức khỏe ruột, cân bằng đường huyết, chuyển hóa lipid và trọng lượng cơ thể. Về mặt vật lí, tinh bột kháng tiêu hóa có tính chất tương đương với tinh bột, do đó đã được ứng dụng rộng rãi trong công nghiệp chế biến thực phẩm. Mục tiêu của bài viết là tổng quan về các loại tinh bột kháng tiêu hóa; phương pháp vật lí, hóa học và kết hợp với enzyme, chất béo cùng các yếu tố ảnh hưởng đến quá trình tạo thành các loại tinh bột kháng khác nhau.
Abstract: Starch serves as a crucial energy source in the human diet. Resistant starch (RS) is the portion that remains undigested in the small intestine, undergoing fermentation by gut bacteria in the colon, resulting in the formation of short-chain fatty acids. Consuming resistant starch has positive impacts on gut health, blood sugar regulation, lipid metabolism, and body weight. Physically, resistant starch shares properties with starch, leading to its widespread application in the food processing industry. This overview briefly covers resistant starches, physical, chemical, and combined methods with enzymes, fats, and factors affecting the formation of different types of resistant starch.
Plan de intervención: Eficiencia operativa en mantenimiento de redes de gas natural
Authors:   , Wittmann Lucas Kevin
Published: October 2024

El Trabajo Final de Maestría consiste en la identificación y análisis de tal problemática a partir de la formulación de una serie de elementos de diagnóstico, con una consecuente propuesta de mejora con el objeto de abordarla y superarla. Es así como en el escrito se llega a conclusiones respecto al funcionamiento del proceso de Identificación y Atención de escapes de gas, generadoras de un impacto relevante en la debida operatoria de la empresa objeto de estudio, con efectos concretos en su eficiencia, su rentabilidad y el riesgo inherente a un escape de gas tanto para las personas, los bienes circundantes y la imagen de la compañía. Se explica la implementación de un sistema de reparación detallando costos y beneficios cualitativos como cuantitativos.
МЕХАНИЗМЫ ЭФФЕКТИВНОГО УПРАВЛЕНИЯ МУНИЦИПАЛЬНЫМИ ЗЕМЛЯМИ
Authors: Алексеева Н.А. , Доронина С.А. , Абашева О.Ю.
Published: October 2024

Земельно-имущественные отношения занимают большую роль в становлении экономического развития российской экономики. Они требуют детальной правовой регламентации и постоянного правового регулирования. Для повышения инвестиционного потенциала земельно-имущественных отношений данные об объектах недвижимости, и особенно земельных участках, должны актуализироваться как можно чаще. Земельные участки значимы в формировании доходов местных бюджетов. Рассмотрены современные проблемы регулирования оборота земельных участков на примере Завьяловского района Удмуртии. Среди них названы: кадастровая стоимость участков, как правило, оказывается завышенной и по статистике в половине случаев оспаривается гражданами и юридическими лицами в комиссиях и судах; уменьшается количество договоров аренды земельных участков; занижен процент отчисления от кадастровой стоимости земельного участка, уплачиваемый в качестве платы на землю; просроченная задолженность по уплате арендных платежей за землю; существование земельных участков, не вовлеченных в хозяйственный оборот. Предложены механизмы повышения доходов местных бюджетов за счет регулирования ставок арендной платы за земли, предоставления скидок за своевременную оплату аренды, система штрафов и другие механизмы. Предложенные механизмы апробированы на основе опросов граждан и юридических лиц, обоснованы прогнозными расчетами.

Land and property relations play a large role in the formation of economic development of the Russian economy. They require detailed legal regulation and constant legal control. To increase the investment potential of land-property relations, data on real estate objects, and especially land plots, should be updated as often as possible. Land plots are significant in the formation of local budget revenues. The modern problems of regulating the turnover of land plots on the example of the Zavyalovsky district of Udmurtia are considered. Among them are named: the cadastral value of plots is usually overestimated and, according to statistics, in half of the cases it is disputed by citizens and legal entities in commissions and courts; the number of land lease agreements is decreasing; the percentage of deduction from the cadastral value of a land plot paid as a payment for land is underestimated; overdue lease payments for land; existence of land plots not involved in economic circulation. Mechanisms have been proposed to increase local budgets by regulating land rent rates, providing discounts for timely rent payment, a system of fines and other mechanisms. The proposed mechanisms have been tested on the basis of surveys of citizens and legal entities, and substantiated by forecast calculations.
festa de Tu Bishvat
Authors: Ferres Dionisio Moreno
Published: October 2024

Este artigo retrata a singularidade da festa de Tu Bishvat, contida no calendário judaico e sua relação com o meio ambiente, principalmente em relação às atuais crises ambientais. Dentro dessa perspectiva, apresentamos vários aspectos, que questionam nossa condição humana histórica, em relação a natureza como apresentamos aspectos distintivos e solenes que demonstram que a tradição judaica entendeu de forma diferente a relação com o meio ambiente, diferenciando-sedos demais povos da crescente fértil e como minoria soube resistir aos contrastes religiosos do panteísmo e do politeísmo com um calendário próprio, festivo e com uma ritualística que revela uma profunda sintonia com toda a natureza e que foram preservados pelos sábios de Israel ao longo dos milênios.
Utilization Of Wordwall as An Application for Elementary School Thematic Learning Evaluation
Authors: Nisa Ani Khoiratun , Noptario Noptario , Muzaini M. Choirul
Published: October 2024

This research is motivated by the problem of boredom and lack of student motivation in participating in learning evaluations that tend to be monotonous in elementary schools. This study aims to reveal the benefits of using Wordwall as an interactive thematic learning evaluation tool. This study uses a qualitative method with a descriptive approach, where data is obtained through interviews with fifth-grade teachers at an elementary school in Bandar Lampung. The study results indicate that using Wordwall increases student engagement and enthusiasm in participating in the evaluation. In addition, Wordwall allows teachers to create more creative and varied assessments and provide direct feedback to students. Although several obstacles exist, such as the need for an internet connection and paid features, Wordwall has proven effective in increasing student learning motivation. Further research is recommended to explore the use of Wordwall at various levels of education and subjects and discuss the development of Wordwall features to be more flexible and easily accessible without technological limitations.
Aplikasi Na-CMC dari bacterial cellulose sebagai emulsifier dalam santan cair instan
Authors: Santosa Budi , Suliana Gatut , Yoweni Mega Christin
Published: October 2024

𝘚𝘢𝘯𝘵𝘢𝘯 𝘬𝘦𝘭𝘢𝘱𝘢 𝘮𝘦𝘮𝘪𝘭𝘪𝘬𝘪 𝘬𝘢𝘳𝘢𝘬𝘵𝘦𝘳𝘪𝘴𝘵𝘪𝘬 𝘮𝘶𝘥𝘢𝘩 𝘮𝘦𝘯𝘨𝘢𝘭𝘢𝘮𝘪 𝘬𝘦𝘳𝘶𝘴𝘢𝘬𝘢𝘯 𝘱𝘢𝘥𝘢 𝘴𝘶𝘩𝘶 𝘬𝘢𝘮𝘢𝘳 𝘬𝘢𝘳𝘦𝘯𝘢 𝘮𝘦𝘯𝘨𝘢𝘯𝘥𝘶𝘯𝘨 𝘢𝘪𝘳, 𝘭𝘦𝘮𝘢𝘬 𝘥𝘢𝘯 𝘱𝘳𝘰𝘵𝘦𝘪𝘯. 𝘒𝘢𝘯𝘥𝘶𝘯𝘨𝘢𝘯 𝘴𝘦𝘯𝘺𝘢𝘸𝘢 𝘪𝘯𝘪 𝘮𝘦𝘯𝘺𝘦𝘣𝘢𝘣𝘬𝘢𝘯 𝘴𝘢𝘯𝘵𝘢𝘯 𝘬𝘦𝘭𝘢𝘱𝘢 𝘮𝘶𝘥𝘢𝘩 𝘥𝘪𝘵𝘶𝘮𝘣𝘶𝘩𝘪 𝘮𝘪𝘬𝘳𝘰𝘣𝘢 𝘱𝘦𝘳𝘶𝘴𝘢𝘬 𝘱𝘢𝘯𝘨𝘢𝘯. 𝘒𝘢𝘯𝘥𝘶𝘯𝘨𝘢𝘯 𝘭𝘦𝘮𝘢𝘬 𝘥𝘪 𝘥𝘢𝘭𝘢𝘮 𝘴𝘢𝘯𝘵𝘢𝘯 𝘫𝘶𝘨𝘢 𝘮𝘦𝘯𝘺𝘦𝘣𝘢𝘣𝘬𝘢𝘯 𝘵𝘦𝘳𝘫𝘢𝘥𝘪𝘯𝘺𝘢 𝘬𝘦𝘵𝘦𝘯𝘨𝘪𝘬𝘢𝘯 𝘢𝘬𝘪𝘣𝘢𝘵 𝘭𝘦𝘮𝘢𝘬 𝘵𝘦𝘳𝘰𝘬𝘴𝘪𝘥𝘢𝘴𝘪 𝘰𝘭𝘦𝘩 𝘶𝘥𝘢𝘳𝘢. 𝘚𝘢𝘭𝘢𝘩 𝘴𝘢𝘵𝘶 𝘴𝘰𝘭𝘶𝘴𝘪 𝘶𝘯𝘵𝘶𝘬 𝘮𝘦𝘯𝘺𝘦𝘭𝘦𝘴𝘢𝘪𝘬𝘢𝘯 𝘮𝘢𝘴𝘢𝘭𝘢𝘩 𝘵𝘦𝘳𝘴𝘦𝘣𝘶𝘵 𝘺𝘢𝘪𝘵𝘶 𝘥𝘪𝘣𝘶𝘢𝘵 𝘮𝘦𝘯𝘫𝘢𝘥𝘪 𝘴𝘢𝘯𝘵𝘢𝘯 𝘤𝘢𝘪𝘳 𝘪𝘯𝘴𝘵𝘢𝘯. 𝘗𝘦𝘯𝘦𝘭𝘪𝘵𝘪𝘢𝘯 𝘪𝘯𝘪 𝘣𝘦𝘳𝘵𝘶𝘫𝘶𝘢𝘯 𝘶𝘯𝘵𝘶𝘬 𝘮𝘦𝘯𝘨𝘦𝘵𝘢𝘩𝘶𝘪 𝘱𝘦𝘳𝘢𝘯𝘢𝘯 𝘕𝘢𝘵𝘳𝘪𝘶𝘮-𝘊𝘢𝘳𝘣𝘰𝘹𝘺𝘮𝘦𝘵𝘩𝘺𝘭 𝘊𝘦𝘭𝘭𝘶𝘭𝘰𝘴𝘦 (𝘕𝘢-𝘊𝘔𝘊) 𝘥𝘢𝘳𝘪 𝘣𝘢𝘤𝘵𝘦𝘳𝘪𝘢𝘭 𝘤𝘦𝘭𝘭𝘶𝘭𝘰𝘴𝘦 𝘴𝘦𝘣𝘢𝘨𝘢𝘪 𝘦𝘮𝘶𝘭𝘴𝘪𝘧𝘪𝘦𝘳 𝘥𝘢𝘭𝘢𝘮 𝘱𝘦𝘮𝘣𝘶𝘢𝘵𝘢𝘯 𝘴𝘢𝘯𝘵𝘢𝘯 𝘤𝘢𝘪𝘳 𝘪𝘯𝘴𝘵𝘢𝘯. 𝘙𝘢𝘯𝘤𝘢𝘯𝘨𝘢𝘯 𝘱𝘦𝘳𝘤𝘰𝘣𝘢𝘢𝘯 𝘺𝘢𝘯𝘨 𝘥𝘪𝘨𝘶𝘯𝘢𝘬𝘢𝘯 𝘙𝘢𝘯𝘤𝘢𝘯𝘨𝘢𝘯 𝘈𝘤𝘢𝘬 𝘒𝘦𝘭𝘰𝘮𝘱𝘰𝘬 𝘧𝘢𝘬𝘵𝘰𝘳 𝘵𝘶𝘯𝘨𝘨𝘢𝘭, 𝘧𝘢𝘬𝘵𝘰𝘳𝘯𝘺𝘢 𝘺𝘢𝘪𝘵𝘶 𝘬𝘰𝘯𝘴𝘦𝘯𝘵𝘳𝘢𝘴𝘪 𝘕𝘢-𝘊𝘔𝘊 𝘺𝘢𝘯𝘨 𝘵𝘦𝘳𝘥𝘪𝘳𝘪 𝘢𝘵𝘢𝘴 5 𝘭𝘦𝘷𝘦𝘭 : 𝘌1 = 𝘕𝘢-𝘊𝘔𝘊 0,5% (𝘣/𝘷), 𝘌2 = 𝘕𝘢-𝘊𝘔𝘊 1% (𝘣/𝘷), 𝘌3 = 𝘕𝘢-𝘊𝘔𝘊 1,5% (𝘣/𝘷), 𝘌4 = 𝘕𝘢-𝘊𝘔𝘊 2% (𝘣/𝘷), 𝘌5 = 𝘕𝘢-𝘊𝘔𝘊 2,5% (𝘣/𝘷).𝘗𝘢𝘳𝘢𝘮𝘦𝘵𝘦𝘳 𝘺𝘢𝘯𝘨 𝘥𝘪𝘢𝘮𝘢𝘵𝘪 𝘬𝘢𝘥𝘢𝘳 𝘢𝘪𝘳, 𝘬𝘢𝘥𝘢𝘳 𝘴𝘦𝘳𝘢𝘵 𝘥𝘢𝘯 𝘥𝘢𝘺𝘢 𝘭𝘢𝘳𝘶𝘵.     𝘏𝘢𝘴𝘪𝘭 𝘱𝘦𝘯𝘦𝘭𝘪𝘵𝘪𝘢𝘯 𝘮𝘦𝘯𝘶𝘯𝘫𝘶𝘬𝘬𝘢𝘯 𝘬𝘢𝘥𝘢𝘳 𝘢𝘴𝘢𝘮 𝘭𝘦𝘮𝘢𝘬 𝘣𝘦𝘣𝘢𝘴 𝘱𝘢𝘭𝘪𝘯𝘨 𝘵𝘪𝘯𝘨𝘨𝘪 𝘴𝘢𝘯𝘵𝘢𝘯 𝘤𝘢𝘪𝘳 𝘪𝘯𝘴𝘵𝘢𝘯 𝘱𝘢𝘥𝘢 𝘱𝘦𝘳𝘭𝘢𝘬𝘶𝘢𝘯 𝘊1 (𝘕𝘢-𝘊𝘔𝘊 0,5%) 𝘴𝘦𝘣𝘦𝘴𝘢𝘳 0,3825%, 𝘷𝘪𝘴𝘬𝘰𝘴𝘪𝘵𝘢𝘴 (𝘬𝘦𝘬𝘦𝘯𝘵𝘢𝘭𝘢𝘯) 𝘱𝘢𝘭𝘪𝘯𝘨 𝘵𝘪𝘯𝘨𝘨𝘪 𝘴𝘦𝘣𝘦𝘴𝘢𝘳 1,132𝘤𝘗 𝘱𝘢𝘥𝘢 𝘱𝘦𝘳𝘭𝘢𝘬𝘶𝘢𝘯 𝘊5 (𝘕𝘢-𝘊𝘔𝘊 2,5%), 𝘴𝘦𝘥𝘢𝘯𝘨𝘬𝘢𝘯 𝘥𝘢𝘺𝘢 𝘭𝘢𝘳𝘶𝘵 𝘱𝘢𝘭𝘪𝘯𝘨 𝘵𝘪𝘯𝘨𝘨𝘪 𝘱𝘢𝘥𝘢 𝘱𝘦𝘳𝘭𝘢𝘬𝘶𝘢𝘯 𝘊5 (𝘕𝘢-𝘊𝘔𝘊 2,5%) 𝘴𝘦𝘣𝘦𝘴𝘢𝘳 87,83%.
Pengaruh Kualitas Pelayanan dan Harga terhadap Loyalitas Pelanggan Pada Bengkel Revan Motor di Desa Lalong Kecamatan Walendrang
Authors: Adi Adianta , Nurjannah Nurjannah , Rudianto Rudianto
Published: October 2024

Perusahaan dalam mempertahankan konsumen merupakan satu prestasi tersendiri yang mencerminkan kehandalan perusahaan tersebut dalam menjaga kualitas produk yang dihasilkan perusahaan baik barang maupun jasa. Salah satu usaha yang sekarang ini banyak diminati masyarakat yaitu usaha di bidang jasa seperti bengkel kendaraan bermotor. Penelitian ini di lakukukan pada Bengkel Revan Motor di Desa Lalong Kecamatan Walendrang. Waktu penelitian ini diperkirakan dilakukan dalam waktu kurang lebih dua bulan yaitu pada bulan Januari – Februari 2023.Berdasarkan pengolahan data dengan menggunakan analisis regresi linear berganda sebagaimana yang telah diuraikan pada hasil dan pembahasan yaitu 1) Kualitas pelayanan dan harga berpengaruh signifikan terhadap loyalitas pelanggan pada Bengkel Revan Motor di Desa Lalong Kecamatan Walenrang. 2) Kualitas pelayanan berpengaruh signifikan terhadap loyalitas pelanggan pada Bengkel Revan Motor di Desa Lalong Kecamatan Walenrang. 3) Harga berpengaruh signifikan terhadap loyalitas pelanggan pada Bengkel Revan Motor di Desa Lalong Kecamatan Walenrang.
Pengaruh Jumlah Tindak Pidana dan Jumlah Kunjungan Wisatawan Terhadap Pertumbuhan ekonomi
Authors: Herawati Baiq Candra , Soraya Siti , Suhendra Erwin , Primajati Gilang , Rahima Phyta , Hendayanti Ni Putu Nanik
Published: October 2024

Pertumbuhan ekonomi merupakan tolak ukur bagi kesejahteraan masyarakat. Ekonomi yang baik tidak lepas dari minimnya tingkat kirminalitas yang terjadi di suatu wilayah serta adanya dukungan sektor pariwisata yang dijadikan sebagai lahan pekerjaan dan perputaran ekonomi masyarakat. Tujuan penelitian ini yaitu menjelaskan hubungan dan pengaruh dari tindak pidana dan kunjungan wisata terhadap pertumbuhan ekonomi. Metode yang digunakan yaitu regresi linier berganda. Hasil analisis menunjukkan bahwa variabel tindak pidana memiliki nilai signifikansi kurang dari 0,05. Sedangkan variabel kunjungan pariwisata memiliki nilai signifikansi lebih besar dari 0.05. Hal ini dapat menjelasakan bahwa variabel tindak pidana memiliki pengaruh yang besar terhadap pertumbuhan ekonomi. Model regresi linier berganda yang terbentuk memiliki nilai R-Square tinggi yaitu 92,2 %, mengandung makna bahwa variabel tindak pidana dan jumlah kunjungan wisatawan mampu menjelaskan model pertumbuhan ekonomi yang terbentuk. Dari hasil penelitian ini dapat diperoleh informasi bahwa perlunya meminimalisir terjadinya tindak kriminalitas sehingga pola pikir masyarakat mengarah pada perbaikan sumber daya manusia dan pembangunan ekonomi masyarakat daerah.
Analisis Pengaruh Kenyamanan, Bonus dan Tunjangan Terhadap Kinerja Melalui Loyalitas Karyawan Pada Pegadaian Syariah Cabang Pangkajene
Authors: Murni Murni , Samad Abdul , Sujatmiko Sujatmiko
Published: October 2024

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh kenyamanan, bonus dan tunjangan terhadap kinerja melalui loyalitas karyawan pada Pegadaian Syariah Cabang Pangkajene. Penelitian ini menggunakan metode deskriptif kuantitatif dengan menggunakan aplikasi SPSS 26 hasil sebaran kuisioner selama periode penelitian. Populasi dalam penelitian ini adalah karyawan Pegadaian Syariah Cabang Pangkajene berjumlah 38 orang karyawan menggunakan Teknik slovin. Metode analisis dalam penelitian ini menggunakan uji instrumen data, uji asumsi klasik regresi linier berganda, pengujian hipotesis dan analisis path. Hasil penelitian ini menunjukan bahwa secara partial (1) variabel Kenyamanan berpengaruh positif dan signifikan terhadap loyalitas karyawan pada Pegadaian Syariah Cabang Pangkajene (2) Variabel kenyamanan berpengaruh positif dan signifikan terhadap kinerja karyawan pada Pegadaian Syariah Cabang Pangkajene (3) Variabel bonus berpengaruh positif dan signifikan terhadap loyalitas karyawan pada Pegadaian Syariah Cabang Pangkajene (4) Variabel bonus berpengaruh positif dan signifikan terhadap kinerja karyawan pada Pegadaian Syariah Cabang Pangkajene (5) Variabel tunjangan berpengaruh positif dan signifikan terhadap loyalitas karyawan pada Pegadaian Syariah Cabang Pangkajene (6) Variabel tunjangan berpengaruh positif dan signifikan terhadap kinerja karyawan pada Pegadaian Syariah Cabang Pangkajene. (7) Variabel loyalitas berpengaruh positif dan signifikan terhadap kinerja karyawan pada Pegadaian Syariah Cabang. (8) Variabel kenyamanan berpengaruh positif dan signifikan terhadap kinerja melalui loyalitas karyawan pada Pegadaian Syariah Cabang Pangkajene. (9) Variabel bonus berpengaruh positif dan signifikan terhadap kinerja melalui loyalitas karyawan pada Pegadaian Syariah Cabang Pangkajene. (10) Variabel tunjangan berpengaruh positif dan signifikan terhadap kinerja melalui loyalitas karyawan pada Pegadaian Syariah Cabang Pangkajene.
Pengembangan Motivasi dan Kompensasi Terhadap Peningkatan Profesionalitas Tenaga Kesehatan di Kota Makassar
Authors: Gunawan Hendra
Published: October 2024

Penelitian ini bertujuan untuk menganalisis pengaruh motivasi dan kompensasi terhadap profesionalitas tenaga kesehatan di Kota Makassar. Profesionalitas tenaga kesehatan sangat penting dalam memberikan layanan yang berkualitas, dan motivasi serta kompensasi merupakan dua faktor kunci yang memengaruhi kinerja mereka. Penelitian ini menggunakan pendekatan kuantitatif dengan metode survei dan kuesioner sebagai instrumen pengumpulan data. Sampel penelitian terdiri dari tenaga kesehatan yang bekerja di berbagai fasilitas kesehatan di Kota Makassar, seperti rumah sakit, puskesmas, dan klinik. Analisis data dilakukan menggunakan uji regresi linier berganda untuk mengidentifikasi hubungan antara variabel motivasi, kompensasi, dan profesionalitas. Hasil penelitian menunjukkan bahwa motivasi dan kompensasi berpengaruh signifikan dan positif terhadap profesionalitas tenaga kesehatan. Koefisien regresi menunjukkan bahwa kompensasi memiliki pengaruh yang lebih dominan dibandingkan dengan motivasi terhadap peningkatan profesionalitas. Temuan ini mengindikasikan bahwa tenaga kesehatan yang menerima kompensasi yang adil dan sesuai dengan beban kerja serta kontribusinya cenderung memiliki profesionalitas yang lebih tinggi. Meskipun demikian, motivasi juga tetap menjadi faktor penting dalam meningkatkan profesionalitas, khususnya melalui dorongan intrinsik seperti makna pekerjaan dan kepuasan kerja. Implikasi dari penelitian ini adalah perlunya institusi kesehatan untuk merancang strategi kompensasi yang kompetitif dan adil, serta menciptakan lingkungan kerja yang mendukung peningkatan motivasi tenaga kesehatan. Dengan optimalisasi kedua faktor ini, profesionalitas tenaga kesehatan dapat ditingkatkan, yang pada gilirannya akan berdampak positif pada kualitas layanan kesehatan di Kota Makassar. Penelitian ini diharapkan dapat menjadi referensi bagi pembuat kebijakan dan praktisi dalam mengelola sumber daya manusia di sektor kesehatan.
Effects of Microcredit on Socio-Economic Development Indicators: A Study of Ansar-VDP Unnayan Bank Beneficiaries in Bangladesh
Authors: Shahjahan Dr. Md. , Sarwar A. S. M. , Akter Shamima , Tarannum Tasmia
Published: October 2024

Introduction: Bangladesh, a pioneer in microfinance since the 1980s, leads the world in microfinance operations aimed at low-income individuals, often women, in informal businesses. Despite its widespread use for development, the full impact of microfinance on socio-economic indicators remains unclear. This study aims to analyze this influence. Research Question: Despite decades of microfinance for development and poverty reduction, the extent of its impact remains unclear. While many researchers acknowledge microcredit as a tool for socio-economic development, others remain sceptical. This study aims to analyze the influence of microcredit on socio-economic development indicators. Methodology: The researcher compiled a comprehensive list of relevant indicators through a literature review. They then investigated which indicators are most impacted by microcredit, aiming to develop practical strategies to maximize the effectiveness of microcredit programs. Ansar-VDP Unnayan Bank, the sole government-owned bank dedicated to poverty alleviation through microcredit, was chosen as the study site. With a target population of 5.6 million, primarily living below the poverty line, Ansar-VDP Bank serves a significant portion of Bangladesh's impoverished population. Data Collection: Data collection involved structured and semi-structured questionnaires administered by trained bank managers. Results: The study found that microcredit impacts all analyzed indicators, with significant effects on calorie intake and income levels. While other indicators may be influenced, the impact was less pronounced. These findings suggest that microfinance practitioners should prioritize key indicators to achieve the desired outcomes, as positive change in these key areas can potentially influence other indicators.
Patient Experience of Living With Hemophilia A: A Conceptual Model of Humanistic and Symptomatic Experience in Adolescents, Adults, and Children
Authors: Hakimi Zalmai , Ghelani Rakhee , Bystrická Linda , Kragh Nana , Marquis Patrick , Nazir Jameel , McGale Nadine
Published: October 2024

Background: People living with hemophilia A face challenges impacting their daily lives despite treatment innovations. Previous studies have explored perceptions and treatment experiences; however, there is a lack of an evidence-based, comprehensive model to identify concepts (clinical, physical, and psychological functioning) relevant for people with hemophilia A (PwHA). Objectives: The aim of this qualitative study was to address the question: What is the humanistic and symptomatic experience of adolescents, adults, and children living with hemophilia A and what is the impact of hemophilia A on their quality of life? Methods: Participants, identified through patient associations in the UK, were male PwHA and caregivers of male PwHA receiving prophylactic treatment. Qualitative research was conducted involving semistructured telephone interviews with PwHA and caregivers between April 2020 and September 2020 in the UK. Standard analytical techniques of conceptual model development were used. Results: Of 30 participants, 23 were PwHA and 7 were caregivers. A conceptual model was produced describing patient experience of symptoms, physical functioning, treatment experiences, and the impact of symptoms and treatment on daily lives. Participants reported hemophilia-related symptoms, including bleeding, pain, and joint stiffness, as well as difficulties engaging with social and leisure activities. They also reported protection from bleeds provided by their treatment, relief from symptoms, and the resultant sense of normality. Concepts were broadly relevant across all age groups; however, psychological impacts were reported only by adult PwHA, and caregivers reported impacts related to outdoor activities, play, and education. Participants indicated that their ideal treatment would be delivered orally. Discussion: This study highlights the range of symptoms experienced by PwHA across a broad range of age groups, thus enabling the evaluation of relevant concepts across different stages of life. The research supports development of a conceptual model documenting symptoms, impacts, and treatment experience relevant to PwHA. Conclusion: Insights gathered through the interviews and resulting conceptual model support development of new therapies to address the physical and social challenges identified by PwHA and highlight a need for novel hemophilia A treatments that can ease treatment administration, provide adequate level of protection, and enable life to be lived normally.
ABORDAGEM MULTIDISCIPLINARES PARA O TRATAMENTO DE SEQUELAS NEUROPSIQUIÁTRICAS EM PACIENTES COM TRAUMATISMO CRANIOENCEFÁLICO (TCE)
Authors: Almeida Pedro Henrique ferreira Avelar de , Caro Valentina Santos Del , Rifai Arminda El , Rodrigues Raizza Montanari , Cavalcanti Mayara Laguna , Rifai Mario El , Silva Bleno Bezerra , Faé Maria Eduarda De Oliveira Soares , Farias Lis Gabriella Santiago Alves de , Mambrim Gustavo Henrique Miranda , França João Henrique Ferreira , Nogueira Gustavo Silva , Silva Nathalia Grazielle
Published: October 2024

INTRODUÇÃO: Nas últimas décadas, o entendimento sobre a relação entre lesão cerebral traumática (LCT) e saúde mental avançou significativamente. A LCT leve, antes subestimada, agora é reconhecida como uma das principais causas de morbidade. A combinação do trauma físico e emocional causado pela LCT aumenta o risco de complicações neuropsiquiátricas, como transtorno de estresse pós-traumático (TEPT), depressão e demência. Fatores biopsicossociais e neurofisiológicos influenciam os desfechos pós-LCT, destacando a necessidade de mais pesquisas. METODOLOGIA: Foi realizada uma revisão sistemática de estudos dos últimos 10 anos, visando identificar avanços no uso de tecnologias emergentes, como inteligência artificial, para tratar as sequelas neuropsiquiátricas de pacientes com LCT. A personalização do tratamento, considerando os aspectos neuropsiquiátricos individuais, mostrou-se crucial. No entanto, a aceitação dessas tecnologias e a necessidade de ensaios clínicos mais robustos permanecem desafios. RESULTADOS E DISCUSSÃO: A revisão identificou cinco estudos principais que analisam o uso de abordagens multidisciplinares e tecnologias no tratamento de LCT. Os estudos destacam o impacto neuropsiquiátrico, a associação com doenças neurodegenerativas, como Alzheimer, e a relevância do uso de biomarcadores para monitoramento. Concluiu-se que o LCT, mesmo leve, aumenta significativamente o risco de desenvolver condições neurológicas e psiquiátricas subsequentes. CONSIDERAÇÕES FINAIS: A integração de abordagens multidisciplinares e o uso de tecnologias emergentes são essenciais para melhorar o tratamento das sequelas neuropsiquiátricas do TCE. O estudo conclui que o sucesso no tratamento requer tanto avanços tecnológicos quanto abordagens personalizadas e multidimensionais que considerem os aspectos clínicos e psicossociais.
State-of-the-art review on the integration of BIM with pavement management systems
Authors: Retno Retno , Osorio-Sandoval Carlos , Thom Nicholas
Published: October 2024

Pavement management systems require comprehensive data, including design and existing conditions. These data may be utilised to forecast conditions and determine the optimal timing for implementing maintenance measures to reduce expenses. On the other hand, Building Information Modelling (BIM) technology can be used for organising, managing, and exploiting data to assist decision-makers and ease the extensive pavement management process. It is anticipated that leveraging the capabilities of BIM in the pavement management system will lead to a more productive and streamlined management system. This paper reviews the use of BIM for pavement management and its integration with existing pavement management systems. The scope of the review includes both academic and non-academic literature. Upon review, BIM plays a role in all six steps of pavement management systems. These steps include defining the road network, collecting condition data, predicting pavement conditions, selecting appropriate treatments, reporting results, and choosing the optimal pavement management tools. Several highway agencies that manage road assets may be able to reach maturity level 2. Level 2 maturity in pavement management systems focuses on improving collaborative working methods that lead to automated procedures. Three areas may be the focus of future study. First and foremost is integrating BIM with current survey tools and developing analysis based on regulations for each asset management plan. The second is integrating the analytical process from assessing pavement conditions to choosing maintenance options by considering uncertainty analysis and social factors. The final part is to continue proposing information sharing and an automated pavement management system practice.