bluuebunny/crossref_metadata_2025 huggingface dataset:
Emergence of Diverse Epidermal Patterns via the Integration of the Turing Pattern Model with the Majority Voting Model
Authors: Ishida Takeshi
Published: May 2024

Animal skin patterns are increasingly explained using the Turing pattern model proposed by Alan Turing. The Turing model, a self-organizing model, can produce spotted or striped patterns. However, several animal patterns exist that do not correspond to these patterns. For example, the body patterns of the ornamental carp Nishiki goi produced in Japan vary randomly among individuals. Therefore, predicting the pattern of offspring is difficult based on the parent fish. Such a randomly formed pattern could be explained using a majority voting model. This model is a type of cellular automaton model that counts the surrounding states and transitions to high-number states. Nevertheless, the utility of these two models in explaining fish patterns remains unclear. Interestingly, the patterns generated by these two models can be detected among very closely related species. It is difficult to think that completely different epidermal formation mechanisms are used among species of the same family. Therefore, there may be a basic model that can produce both patterns. Herein, the Turing pattern and majority voting method are represented using cellular automata, and the possibility of integrating these two methods is examined. This integrated model is equivalent to both models when the parameters are adjusted. Although this integrated model is extremely simple, it can produce more varied patterns than either one of the individual models. However, further research is warranted to determine whether this model is consistent with the mechanisms involved in the formation of animal fish patterns from a biological perspective.
Evaluation of Rural Healing Landscape DESIGN Based on Virtual Reality and Electroencephalography
Authors: Ren Hongguo , Wang Xue , Zhang Jing , Zhang Lei , Wang Qingqin
Published: May 2024

From the user’s perspective, emotional elements are increasingly being used in design. Researchers have indicated that healing landscapes in rural areas play a positive role in soothing human emotions. In this study, a landscape with healing functions was designed, and 32 subjects experienced emotions in a virtual reality (VR) scene while their 32-channel electroencephalography (EEG) signals were collected. This study compared the brain responses with and without the presence of healing landscape elements and conducted correlation coefficient analysis using eight different regression prediction models to examine the relationship between security, comfort, positivity, and corresponding healing landscape elements. The results show significant improvements in emotions of security, comfort, and positivity post-exposure to the landscape design, especially with certain elements, such as seating, shrubs, and tree pools. EEG data indicate enhanced emotional and cognitive states, particularly relaxation, with increased activity in specific brain regions. The decision tree regression model is the most suitable for our data. It reveals strong correlations between specific healing landscape elements and emotional responses. In the comfort category, “shrubs” show the highest correlation (R² = 0.82), while in the security category, “trees” have the highest correlation (R² = 0.77). Similarly, in the positivity category, “trees” again exhibit the highest correlation (R² = 0.71) with EEG data, indicating their significant impact on these emotional dimensions. This study demonstrates the importance of using scientific methods, such as EEG technology, to validate the principles of emotional design and also underscores the role of green environments in enhancing psychological health and emotional comfort.
Analysis of Out-of-Plane Displacements of a Light Steel Keel Fireproof Exterior Wall and Its Connection with the Steel Frame
Authors: Wang Ang , Gao Ruiyuan , Li Hao , Li Jing , Li Ke
Published: May 2024

Light steel keel fireproof exterior walls are one of the new composite walls that have been widely used in recent years. This paper analyzes the factors affecting the displacements of the connectors and wall panels and modifies the corresponding displacement model. ABAQUS was used to establish the simulation analysis of the L-shaped and special-shaped steel angle component, and the results were compared with the experimental model to verify the rationality. The effect of vertical keel spacing and layout, the number of special-shaped steel angles, the L-shaped steel angle thickness, and the number of self-tapping screws for L-shaped steel angles to steel beams were explored based on the validated finite element model. The calculation model was modified based on the results of the simulation. The results showed that the simulation results fit well with the experimental results, which verified the reliability of the finite element model. The number of connectors and the number of self-tapping screws are the main factors affecting the special-shaped and L-shaped steel angle components, respectively. By modifying the rotation constraint factor of the L-shaped steel angle and adding a discount factor for the wall panel, the accuracy of the associated displacement calculation model could be improved.
Holistic Approach to Niche Formation: A Case on Transition to Nearly Zero-Energy Buildings in Türkiye
Authors: Yiğit Barut Tuğba , Arslan Selçuk Semra
Published: May 2024

The long-term challenges of climate change are becoming increasingly evident. Considering the ever-increasing need for energy in parallel with population growth and the impact of greenhouse gases, the built environment is among the issues that should be addressed as a priority. As international agreements, the EU, and national legislation become institutionalized, the need to decarbonize the built environment increases. For this reason, there is a need for an understanding that enables the transition to a more sustainable society. In line with this understanding, a transition to zero-energy buildings is required. In this article, the evaluation framework is created by combining the Transition Management (TM) approach, which is a framework developed to understand long-term changes in culture, structure, and practices for sustainable development solutions, and the Strategic Niche Management (SNM) approach, which encourages technological and social change to initiate sustainable innovations at the niche level. Applications regarding energy efficiency and niche formation for the built environment in Türkiye (Gaziantep) were discussed. When the applications and theories are evaluated together, it can be seen that the applications carried out in Gaziantep regarding Nearly Zero Energy Buildings may be starter experiments. However, these projects are insufficient to create a niche, and the developments are progressing very slowly.
Experimental-Numerical Assessment of Mechanical Behavior of Laboratory-Made Steel and NiTi Shape Memory Alloy Wire Ropes
Authors: Narjabadifam Peyman , Fazlalipour Neda , Mollaei Somayeh , Momeni Mohammad , Watandoust Ali Saman , Chavoshi Mahdi , Babaeian Amini Alireza , Karazmay Farshad
Published: May 2024

The mechanical behaviors of laboratory-fabricated steel and superelastic shape memory alloy (SMA) wire ropes are assessed in this study through a comprehensive approach encompassing both experimental investigations and finite element (FE) numerical simulations. The assessment of steel wire ropes involves experimental scrutiny under sinusoidal cyclic loading and natural earthquake loading conditions. In parallel, SMA wire ropes’ behaviors are analyzed utilizing FE simulations employing the widely acknowledged ABAQUS software version 2020. The validation of all numerical simulations is undertaken against the experimentally observed behaviors. Moreover, full-scale steel wire ropes are subjected to shaking table tests to validate the simulations, facilitating a comparative analysis between the mechanical responses of SMA and steel wire ropes. The findings demonstrate that SMA wire ropes exhibit superelastic behavior akin to SMA wires, with marginal variations in overall response observed across distinct configurations, akin to steel wire ropes. Furthermore, augmenting the helix angle of SMA wire ropes results in reduced stress and increased strain when exposed to the El Centro earthquake scenario. Nevertheless, the mechanical response of SMA wire ropes closely mirrors that of a single wire.
Wind-Induced Dynamic Response of Inter-Story Isolated Tall Buildings with Friction Pendulum Bearing Based on an Enhanced Simplified Model
Authors: Li Zhihao , Xu Zhiran , Huang Guoqing , Liu Zhanfang
Published: May 2024

Isolation technology, especially for base isolation, is increasingly being applied in earthquake-prone areas. To satisfy some special demands (such as prevention from seawater erosion of an isolation layer, story-adding retrofit of existing buildings, avoidance of collision between base-isolated tall buildings, and so on), the isolation layer sometimes has to be set in the middle of a building to constitute inter-story isolated buildings. This special structural form inevitably encounters strong wind loads during service life, and its wind-resistant performance deserves to be investigated. This study conducts the wind-induced vibration analysis of inter-story isolated tall buildings with friction pendulum bearing (FPB). The nonlinear time domain analysis model and statistical linearization method to compute the wind-induced response of FPB inter-story isolated tall buildings are addressed based on an enhanced simplified model. Considering the independence of the upper and lower structures, two structural design schemes for inter-story isolated tall buildings are provided. Their dynamic characteristics are analyzed, and wind-induced responses are compared. Finally, the accuracy of the statistical linearization method is verified. This study provides an important theoretical basis for the structural design and wind resistance of inter-story isolated tall buildings.
Bimodal Effect of NKG2A Blockade on Intratumoral and Systemic CD8 T Cell Response Induced by Cancer Vaccine
Authors: Riva Erika , Carboni Susanna , di Berardino-Besson Wilma , Moyat Mati , Belnoue Elodie , Devy-Dimanche Laetitia , Rossi Matteo
Published: May 2024

Immune check-point blockade (ICB) has revitalized cancer immunotherapy, showing unprecedented efficacy despite only a narrow number of indications and with limited long-term protection. Cancer vaccines are promising combination partners for ICB to widen the patient population profiting from these treatments. Therapeutic heterologous prime-boost vaccination with KISIMATM protein vaccine and VSV-GP-TAg oncolytic virus was shown to inflame the tumor microenvironment, promoting significant infiltration of antigen-specific CD8 T cells resulting in robust antitumoral efficacy in mouse tumor models, and clinical trials are currently ongoing. Here, we report the impact of NKG2A blockade on antitumoral CD8 T cell immune response elicited by KISIMA—VSV-GP-TAg vaccination in tumor mouse models. Combination therapy significantly reduced the amount of vaccine-induced exhausted CD8 T cells infiltrating the tumor, resulting in short-term improved tumor growth control and prolonged mouse survival, while it also influenced the establishment of systemic effector memory CD8 T cell response. Taken together, these data show a compartment-dependent effect of NKG2A blockade on cancer vaccine-induced T cell immunity, increasing intratumoral T cell efficacy and attenuating the development of peripheral effector memory CD8 T cell response.
Single-Cell Profiling Reveals the Impact of Genetic Alterations on the Differentiation of Inflammation-Induced Murine Colon Tumors
Authors: Ghobashi Ahmed H. , Lanzloth Rosie , Ladaika Christopher A. , Masood Ashiq , O’Hagan Heather M.
Published: May 2024

Genetic mutations and chronic inflammation of the colon contribute to the development of colorectal cancer (CRC). Using a murine model of inflammation-induced colon tumorigenesis, we determined how genetic mutations alter colon tumor cell differentiation. Inflammation induced by enterotoxigenic Bacteroides fragilis (ETBF) colonization of multiple intestinal neoplasia (MinApcΔ716/+) mice triggers loss of heterozygosity of Apc causing colon tumor formation. Here, we report that the addition of BRAFV600E mutation (BRAFF-V600ELgr5tm1(Cre/ERT2)CleMinApcΔ716/+, BLM) or knocking out Msh2 (Msh2LoxP/LoxPVil1-creMinApcΔ716/+, MSH2KO) in the Min model altered colon tumor differentiation. Using single-cell RNA sequencing, we uncovered the differences between BLM, Min, and MSH2KO tumors at a single-cell resolution. BLM tumors showed an increase in differentiated tumor epithelial cell lineages and a reduction in the tumor stem cell population. Interestingly, the tumor stem cell population of BLM tumors had revival colon stem cell characteristics with low WNT signaling and an increase in RevCSC marker gene expression. In contrast, MSH2KO tumors were characterized by an increased tumor stem cell population that had higher WNT signaling activity compared to Min tumors. Furthermore, overall BLM tumors had higher expression of transcription factors that drive differentiation, such as Cdx2, than Min tumors. Using RNA velocity, we identified additional potential regulators of BLM tumor differentiation such as NDRG1. The role of CDX2 and NDRG1 as putative regulators for BLM tumor cell differentiation was verified using organoids derived from BLM tumors. Our results demonstrate the critical connections between genetic mutations and cell differentiation in inflammation-induced colon tumorigenesis. Understanding such roles will deepen our understanding of inflammation-associated colon cancer.
Immune Checkpoint Inhibitors in Hepatocellular Carcinoma and Their Hepatic-Related Side Effects: A Review
Authors: Ruli Thomas M. , Pollack Ethan D. , Lodh Atul , Evers Charles D. , Price Christopher A. , Shoreibah Mohamed
Published: May 2024

Primary liver cancer is one of the leading causes of cancer mortality worldwide, with hepatocellular carcinoma (HCC) being the most prevalent type of liver cancer. The prognosis of patients with advanced, unresectable HCC has historically been poor. However, with the emergence of immunotherapy, specifically immune checkpoint inhibitors (ICIs), there is reason for optimism. Nevertheless, ICIs do not come without risk, especially when administered in patients with HCC, given their potential underlying poor hepatic reserve. Given their novelty in the management of HCC, there are few studies to date specifically investigating ICI-related side effects on the liver in patients with underlying HCC. This review will serve as a guide for clinicians on ICIs’ role in the management of HCC and their potential side effect profile. There will be a discussion on ICI-related hepatotoxicity, the potential for hepatitis B and C reactivation with ICI use, the potential for the development of autoimmune hepatitis with ICI use, and the risk of gastrointestinal bleeding with ICI use. As ICIs become more commonplace as a treatment option in patients with advanced HCC, it is imperative that clinicians not only understand the mechanism of action of such agents but also understand and are able to identify hepatic-related side effects.
Utility of a Multi-Marker Panel with Ultrasound for Enhanced Classification of Adnexal Mass
Authors: Stephens Andrew N. , Hobbs Simon J. , Kang Sung-Woog , Oehler Martin K. , Jobling Tom W. , Allman Richard
Published: May 2024

Pre-surgical clinical assessment of an adnexal mass typically relies on transvaginal ultrasound for comprehensive morphological assessment, with further support provided by biomarker measurements and clinical evaluation. Whilst effective for masses that are obviously benign or malignant, a large proportion of masses remain sonographically indeterminate at surgical referral. As a consequence, post-surgical diagnoses of benign disease can outnumber malignancies up to 9-fold, while less than 50% of cancer cases receive a primary referral to a gynecological oncology specialist. We recently described a blood biomarker signature (multi-marker panel—MMP) that differentiated patients with benign from malignant ovarian disease with high accuracy. In this study, we have examined the use of the MMP, both individually and in combination with transvaginal ultrasound, as an alternative tool to CA-125 for enhanced decision making in the pre-surgical referral process.
Sleep-Disordered Breathing and Associated Comorbidities among Preschool-Aged Children with Down Syndrome
Authors: Kolstad Tessa K. , DelRosso Lourdes M. , Tablizo Mary Anne , Witmans Manisha , Cho Yeilim , Sobremonte-King Michelle
Published: May 2024

Children with Down syndrome (DS) are at high risk of sleep-disordered breathing (SDB). The American Academy of Pediatrics recommends a polysomnogram (PSG) in children with DS prior to the age of 4. This retrospective study examined the frequency of SDB, gas exchange abnormalities, co-morbidities, and surgical management in children with DS aged 2–4 years old at Seattle Children’s Hospital from 2015–2021. A total of 153 children underwent PSG, with 75 meeting the inclusion criteria. The mean age was 3.03 years (SD 0.805), 56% were male, and 54.7% were Caucasian. Comorbidities included (n, %): cardiac (43, 57.3%), dysphagia or aspiration (24, 32.0%), prematurity (17, 22.7%), pulmonary (16, 21.3%), immune dysfunction (2, 2.7%), and hypothyroidism (23, 30.7%). PSG parameter data collected included (mean, SD): obstructive AHI (7.9, 9.4) and central AHI (2.4, 2.4). In total, 94.7% met the criteria for pediatric OSA, 9.5% met the criteria for central apnea, and 9.5% met the criteria for hypoventilation. Only one child met the criteria for hypoxemia. Overall, 60% had surgical intervention, with 88.9% of these being adenotonsillectomy. There was no statistically significant difference in the frequency of OSA at different ages. Children aged 2–4 years with DS have a high frequency of OSA. The most commonly encountered co-morbidities were cardiac and swallowing dysfunction. Among those with OSA, more than half underwent surgical intervention, with improvements in their obstructive apnea hypopnea index, total apnea hypopnea index, oxygen saturation nadir, oxygen desaturation index, total arousal index, and total sleep duration. This highlights the importance of early diagnosis and appropriate treatment. Our study also suggests that adenotonsillar hypertrophy is still a large contributor to upper airway obstruction in this age group.
Correction: Geiger et al. Reassessing and Extending the European Standards of Care for Newborn Health: How to Keep Reference Standards in Line with Current Evidence. Children 2024, 11, 179
Authors: Geiger Isabel , Kostenzer Johanna , Matthäus Valerie ,   on behalf of the ESCNH Chair Committee, Mader Silke , Zimmermann Luc J. I.
Published: May 2024

In the original publication [...]
Polysomnographically Defined Restless Sleep Disorder and Periodic Limb Movements during Sleep in Children Born Prematurely
Authors: DelRosso Lourdes M. , Artinian Hovig , Mogavero Maria P. , Bruni Oliviero , Witmans Manisha , Tablizo Mary Anne , Sobremonte-King Michelle , Ferri Raffaele
Published: May 2024

Introduction: Children born prematurely (<37 weeks’ gestation) are at increased risk of perinatal complications, comorbidities, and iron deficiency. Iron deficiency is associated with restless legs syndrome and periodic limb movement disorder. In this study, we assessed the prevalence of restless sleep disorder (RSD) and elevated periodic limb movements during sleep (PLMS) in children born prematurely who underwent polysomnography. Methods: A retrospective chart review of sleep studies was conducted in children aged 1–18 years (median age 4 years) with a history of premature birth. Children with genetic syndrome, airway surgery, or tracheostomy were excluded. Three groups were compared: children with PLMS index >5, children with RSD, and children with neither elevated PLMS index nor RSD. Results: During the study, 2577 sleep studies were reviewed. Ninety-two studies fit our criteria and were included in the analysis. The median age at birth was 31 weeks, and the interquartile range (IQR) was 27–34 weeks. A total of 32 (34.8%) children were referred for restless sleep and 55 (59.8%) for snoring. After polysomnography, 18% were found to have a PLMS index >5/h, and 14% fit the criteria for restless sleep disorder (RSD). There were no statistically significant differences in PSG parameters among the children with RSD, PLMS, and the remaining group, except for lower obstructive apnea/hypopnea index (Kruskal–Wallis ANOVA 8.621, p = 0.0135) in the RSD group (median 0.7, IQR 0.3–0.9) than in the PLMS (median 1.7, IQR 0.7–3.5) or the non-RSD/non-PLMS (median 2.0, IQR 0.8–4.5) groups. Conclusions: There was an elevated frequency of RSD and elevated PLMS in our cohort of children born prematurely. Children born prematurely are at higher risk of iron deficiency which can be a contributor factor to sleep -related movement disorders. These results add new knowledge regarding the prevalence of RSD and PLMS in these children.
Endocrine and Transcriptome Changes Associated with Testicular Growth and Differentiation in Atlantic Salmon (Salmo salar L.)
Authors: Skjold Vetle , Afanasyev Sergey , Burgerhout Erik , Sveen Lene , Rørvik Kjell-Arne , Mota Vasco Felipe Cardoso Neves , Dessen Jens-Erik , Krasnov Aleksei
Published: May 2024

Sexual maturation of Atlantic salmon males is marked by dramatic endocrine changes and rapid growth of the testes, resulting in an increase in the gonad somatic index (GSI). We examined the association of gonadal growth with serum sex steroids, as well as pituitary and testicular gene expression levels, which were assessed with a DNA oligonucleotide microarray. The testes transcriptome was stable in males with a GSI < 0.08% despite the large difference between the smallest and the largest gonads. Fish with a GSI ≥ 0.23% had 7–17 times higher serum levels of five male steroids and a 2-fold increase in progesterone, without a change in cortisol and related steroids. The pituitary transcriptome showed an upregulation of the hormone-coding genes that control reproduction and behavior, and structural rearrangement was indicated by the genes involved in synaptic transmission and the differentiation of neurons. The observed changes in the abundance of testicular transcripts were caused by the regulation of transcription and/or disproportional growth, with a greater increase in the germinative compartment. As these factors could not be separated, the transcriptome results are presented as higher or lower specific activities (HSA and LSA). LSA was observed in 4268 genes, including many genes involved in various immune responses and developmental processes. LSA also included genes with roles in female reproduction, germinal cell maintenance and gonad development, responses to endocrine and neural regulation, and the biosynthesis of sex steroids. Two functional groups prevailed among HSA: structure and activity of the cilia (95 genes) and meiosis (34 genes). The puberty of A. salmon testis is marked by the predominance of spermatogenesis, which displaces other processes; masculinization; and the weakening of external regulation. Results confirmed the known roles of many genes involved in reproduction and pointed to uncharacterized genes that deserve attention as possible regulators of sexual maturation.
Seismo-Stratigraphic Data of Wave-Cut Marine Terraces in the Licosa Promontory (Southern Tyrrhenian Sea, Italy)
Authors: Aiello Gemma , Caccavale Mauro
Published: May 2024

Some seismo-stratigraphic evidence on the occurrence of wave-cut marine terraces in the Licosa promontory (Southern Tyrrhenian Sea, Italy) based on Sub-bottom Chirp seismic sections is herein presented. Such evidence is provided by marine terraced surfaces situated at various water depths below sea level and etched into the rocky acoustic basement, which are extensively extending in the seaward extension of the Licosa promontory. It is possible that the isotopic stratigraphy and the terraced marine surfaces are connected, so they can be attributed and dated indirectly. The geologic study of seismic profiles has pointed to the prominence of the acoustic basement, extending to the seabed close to the coast and subsiding seawards under the Quaternary marine succession. Ancient remains of marine terraces, found at a range of water depths between 5 m and 50 m, have documented the major morphological changes of the acoustic basement during the Late Quaternary.
The Role of Adsorption Phenomena in ac Conductivity Measurements of Dielectric Nanoparticle Suspensions
Authors: Chikina Ioulia , Varlamov Andrey
Published: May 2024

The authors of numerous measurements of conductivity for suspensions of nanoparticles of various types carried out in the last decade came to the general conclusion that the well-known Maxwell’s theory is not applicable to quantitative explanation of the properties of such systems. In the present work, we demonstrate that the Maxwell’s theory can be still applicable even for such systems, but the specifics of the standard ac measurements have to be correctly taken into account. Namely, the dependence of the capacitance of “metal–electrolyte” cuvette boundaries on nanoparticle adsorption, which in its turn dramatically depends on nanoparticle concentration, has to be taken into account. The latter circumstance strongly (via the RC characteristic of the circuit) affects the results of conductivity measurements. We propose the new algorithm of the impedance measurement data analysis for the particles’ concentration dependence of conductivity σ(ϕ) (where ϕ is the volume fraction of nanoparticles in suspension) for the suspensions of the diamante nanoparticles in alcohol which demonstrates the adequate correspondence of the Maxwell’s theory to the available experimental findings.
Survival after Stereotactic Radiosurgery in the Era of Targeted Therapy: Number of Metastases No Longer Matters
Authors: de Boisanger James , Brewer Martin , Fittall Matthew W. , Tran Amina , Thomas Karen , Dreibe Sabine , Creak Antonia , Solda Francesca , Konadu Jessica , Taylor Helen , Saran Frank , Welsh Liam , Rosenfelder Nicola
Published: May 2024

Randomised control trial data support the use of stereotactic radiosurgery (SRS) in up to 4 brain metastases (BMs), with non-randomised prospective data complementing this for up to 10 BMs. There is debate in the neuro-oncology community as to the appropriateness of SRS in patients with >10 BMs. We present data from a large single-centre cohort, reporting survival in those with >10 BMs and in a >20 BMs subgroup. A total of 1181 patients receiving SRS for BMs were included. Data were collected prospectively from the time of SRS referral. Kaplan–Meier graphs and logrank tests were used to compare survival between groups. Multivariate analysis was performed using the Cox proportional hazards model to account for differences in group characteristics. Median survival with 1 BM (n = 379), 2–4 BMs (n = 438), 5–10 BMs (n = 236), and >10 BMs (n = 128) was 12.49, 10.22, 10.68, and 10.09 months, respectively. Using 2–4 BMs as the reference group, survival was not significantly different in those with >10 BMs in either our univariable (p = 0.6882) or multivariable analysis (p = 0.0564). In our subgroup analyses, median survival for those with >20 BMs was comparable to those with 2–4 BMs (10.09 vs. 10.22 months, p = 0.3558). This study contributes a large dataset to the existing literature on SRS for those with multi-metastases and supports growing evidence that those with >10 BMs should be considered for SRS.
The Mediating Role of Exercise in Depression and Fatigue in Patients with Advanced Cancer
Authors: Calderon Caterina , Gustems Marina , Obispo Berta , García-García Teresa , Hernández Raquel , Fernández-Montes Ana , Jiménez-Fonseca Paula
Published: May 2024

This study explored the interconnections between sociodemographic elements, depression, fatigue, and exercise in patients suffering from incurable neoplasm, particularly emphasizing the mediating influence of exercise on the relationship between depression and fatigue This was a prospective, multicenter, observational study involving 15 hospitals across Spain. After three months of systemic cancer treatment, participants completed the Brief Symptom Inventory (BSI), the Godin-Shephard Leisure-Time Physical Activity Questionnaire (GSLTPAQ) and the Fatigue Assessment Scale (FAS) to measure levels of depression, fatigue, and exercise, respectively. A total of 616 subjects participated in this study. Activity levels differed markedly according to educational attainment, marital, and work status. There was a negative correlation between physical activity and depression, and a positive correlation between depression and fatigue (β = −0.18, and β = 0.46, respectively). Additionally, physical activity inversely influenced fatigue levels (β = 0.21). Physical activity served as a partial intermediary in the link between depression and fatigue among patients with advanced, unresectable cancer. Healthcare providers are urged to consider both the physical and emotional dimensions of cancer treatment, implementing physical activity programs to enhance overall patient quality of life and mental health.
Oncologist-Reported Barriers and Facilitators to Offering Cancer Clinical Trials to Their Patients
Authors: Castillo Brenda S. , Boehmer Leigh , Schrag Janelle , Howson Alexandra , Oyer Randall , Pierce Lori , Barrett Nadine J. , Guerra Carmen E.
Published: May 2024

NCCN guidelines indicate that cancer clinical trials (CCTs) are the best management for patients with cancer. However, only 5% of patients enroll in them. We examined oncologists’ perceived barriers and facilitators to discussing CCTs. This qualitative study was part of the ASCO-ACCC Initiative to Increase Racial and Ethnic Diversity in Clinical Trials. Barriers and facilitators at the system, trial, provider, and patient levels were examined. To achieve triangulation, patient encounters were reviewed using chart-stimulated recall (CSR) methods, thereby obtaining a valid assessment of physician performance. Ten oncology providers participated in this study. Nine were oncologists, and one was a clinical research coordinator; five were female; four were White; three were Asian; and three were Black. Barriers to offering CCTs were a lack of trial availability; ineligibility; a lack of knowledge; assumptions about patient interest, benefits, or harms; patient’s disease factors; and negative attitudes. Facilitators of offering CCTs were a physical space to discuss trials; greater trial availability; a systematic approach to offering trials; patient factors; patients seeking trials; a lack of comorbidities; patients being younger in age; patients being aware of, asking about, or hearing of trials from their surgeon; and higher levels of altruism. Many of the cited barriers are addressable with the cited facilitators. A larger study is needed to generalize and validate these findings.
Pulmonary Hypertension and Hyperglycemia—Not a Sweet Combination
Authors: Bruck Or , Pandit L.
Published: May 2024

Hyperglycemia and pulmonary hypertension (PH) share common pathological pathways that lead to vascular dysfunction and resultant cardiovascular complications. These shared pathologic pathways involve endothelial dysfunction, inflammation, oxidative stress, and hormonal imbalances. Individuals with hyperglycemia or pulmonary hypertension also possess shared clinical factors that contribute to increased morbidity from both diseases. This review aims to explore the relationship between PH and hyperglycemia, highlighting the mechanisms underlying their association and discussing the clinical implications. Understanding these common pathologic and clinical factors will enable early detection for those at-risk for complications from both diseases, paving the way for improved research and targeted therapeutics.
Arteriovenous Fistula: The Case of a Rare Complication after Minimal Percutaneous Nephrostomy and Brief Review
Authors: Dănău Răzvan Alexandru , Petca Răzvan-Cosmin , Constantin Traian Vasile , Petca Aida , Predoiu Gabriel , Jinga Viorel
Published: May 2024

Percutaneous renal surgery, although much less invasive than other procedures, is subject to several complications, which can occur at any time during the course of treatment, starting from the performance of the minimal nephrostomy procedure. We present an extremely rare vascular complication of percutaneous nephrostomy represented by arteriovenous fistula that occurred in a 24-year-old patient known to have right ureteropelvic junction obstruction operated with the absence of double-J catheter permeability and grade II-III hydronephrosis for which minimal percutaneous nephrostomy was urgently fitted. The arteriovenous fistula was resolved by supraselective artery embolization.
Integrating EEG and Ensemble Learning for Accurate Grading and Quantification of Generalized Anxiety Disorder: A Novel Diagnostic Approach
Authors: Luo Xiaodong , Zhou Bin , Fang Jiaqi , Cherif-Riahi Yassine , Li Gang , Shen Xueqian
Published: May 2024

Current assessments for generalized anxiety disorder (GAD) are often subjective and do not rely on a standardized measure to evaluate the GAD across its severity levels. The lack of objective and multi-level quantitative diagnostic criteria poses as a significant challenge for individualized treatment strategies. To address this need, this study aims to establish a GAD grading and quantification diagnostic model by integrating an electroencephalogram (EEG) and ensemble learning. In this context, a total of 39 normal subjects and 80 GAD patients were recruited and divided into four groups: normal control, mild GAD, moderate GAD, and severe GAD. Ten minutes resting state EEG data were collected for every subject. Functional connectivity features were extracted from each EEG segment with different time windows. Then, ensemble learning was employed for GAD classification studies and brain mechanism analysis. Hence, the results showed that the Catboost model with a 10 s time window achieved an impressive 98.1% accuracy for four-level classification. Particularly, it was found that those functional connections situated between the frontal and temporal lobes were significantly more abundant than in other regions, with the beta rhythm being the most prominent. The analysis framework and findings of this study provide substantial evidence for the applications of artificial intelligence in the clinical diagnosis of GAD.
Ising’s Roots and the Transfer-Matrix Eigenvalues
Authors: Folk Reinhard , Holovatch Yurij
Published: May 2024

Today, the Ising model is an archetype describing collective ordering processes. As such, it is widely known in physics and far beyond. Less known is the fact that the thesis defended by Ernst Ising 100 years ago (in 1924) contained not only the solution of what we call now the ‘classical 1D Ising model’ but also other problems. Some of these problems, as well as the method of their solution, are the subject of this note. In particular, we discuss the combinatorial method Ernst Ising used to calculate the partition function for a chain of elementary magnets. In the thermodynamic limit, this method leads to the result that the partition function is given by the roots of a certain polynomial. We explicitly show that ‘Ising’s roots’ that arise within the combinatorial treatment are also recovered by the eigenvalues of the transfer matrix, a concept that was introduced much later. Moreover, we discuss the generalization of the two-state model to a three-state one presented in Ising’s thesis, which is not included in his famous paper of 1925 (E. Ising, Z. Physik 31 (1925) 253). The latter model can be considered as a forerunner of the now-abundant models with many-component order parameters.
High-Throughput Polar Code Decoders with Information Bottleneck Quantization
Authors: Kestel Claus , Johannsen Lucas , Wehn Norbert
Published: May 2024

In digital baseband processing, the forward error correction (FEC) unit belongs to the most demanding components in terms of computational complexity and power consumption. Hence, efficient implementation of FEC decoders is crucial for next-generation mobile broadband standards and an ongoing research topic. Quantization has a significant impact on the decoder area, power consumption and throughput. Thus, lower bit widths are preferred for efficient implementations but degrade the error correction capability. To address this issue, a non-uniform quantization based on the Information Bottleneck (IB) method is proposed that enables a low bit width while maintaining the essential information. Many investigations on the use of the IB method for Low-density parity-check code) LDPC decoders exist and have shown its advantages from an implementation perspective. However, for polar code decoder implementations, there exists only one publication that is not based on the state-of-the-art Fast Simplified Successive-Cancellation (Fast-SSC) decoding algorithm, and only synthesis implementation results without energy estimation are shown. In contrast, our paper presents several optimized Fast-SSC polar code decoder implementations using IB-based quantization with placement and routing results using advanced 12 nm FinFET technology. Gains of up to 16% in area and 13% in energy efficiency are achieved with IB-based quantization at a Frame Error Rate (FER) of 10−7 and a polar code of N=1024,R=0.5 compared to state-of-the-art decoders.
Opportunities and Barriers to Biogas Adoption in Malawi
Authors: Kulugomba Regina , Mapoma Harold W. T. , Gamula Gregory , Blanchard Richard , Mlatho Stanley
Published: May 2024

Malawi has the potential to explore the utilization of biogas technology. The technology has existed in the country for decades. However, the uptake has been lower than expected. Further, there has been a high rate of dis-adoption of the installed systems. To deal with the problem, this study explored the opportunities and barriers to biogas technology to enhance biogas adoption and utilization in Malawi. Qualitative research methods using key informant interviews were employed to collect the data from biogas adopters, dis-adopters, potential adopters, and experts. A total of 22 households and 6 experts were interviewed. The findings of the study show that the country has opportunities for biogas adoption and utilization. The most mentioned opportunities were livestock farming practices, constraints to access to reliable energy sources, associated benefits of biogas technology, and land holding. However, the adoption of the technology has faced several challenges. Commonly cited barriers were the high installation and maintenance costs, inadequate feedstock, inappropriate dissemination approaches, lack of training after installation services and expertise, lack of reliable water sources, absence of ownership, lack of cooperation amongst institutions involved in biogas promotion, lack of a coordinating body for institutions involved in biogas dissemination, lack of standards, and socio-cultural factors. To overcome the challenges, strategies were identified, and these include the provision of incentives, loans and subsidies, provision of technical support services, having demonstration sites, employing suitable dissemination approaches, co-digestion or diversification of raw materials, awareness campaigns, and collaboration amongst sectors involved in biogas dissemination.
Simulation and Characterization of Micro-Discharge Phenomena Induced by Glitch Micro-Defects on an Insulated Pull Rod Surface
Authors: Niu Shu , Li Shuai , Liang Jizhong , Li Guodong , Hu Fan , Zhang Hai , Zhu Yujie , Fan Xianhao , Li Chuanyang
Published: May 2024

The reliability of GIS (gas-insulated switchgear) circuit breakers significantly depends on the condition of the insulated pull rods, with micro-defects on their surface posing a potential risk for micro-discharges and breakdown incidents. Experimentally investigating these micro-discharges is challenging due to their minute nature. This study introduces a framework to examine the linkage between micro-defects and micro-discharges, coupled with numerical simulations of the micro-discharge process in insulated pull rods afflicted by surface infiltration flaws under operational conditions. Initially, samples containing micro-defects were sectioned via water jet cutting for microstructural analysis through white light interferometry. Subsequently, a two-dimensional axisymmetric model simulating positive corona discharge from a needle to a plate electrode was employed to derive the relationship between charged particle density and the electric field in SF6 and air. Building on these observations, a micro-discharge model specific to micro-defects was developed. Comparative analysis of micro-discharge behaviors in SF6 and air for identical defect types was conducted. This research framework elucidates the discharge dynamics of charged particles in SF6 and air during micro-discharge events, shedding light on the mechanisms underpinning micro-discharges triggered by insulation rod defects.
Carbon Pricing Impacts on Four Pollutants: A Cross-Country Analysis
Authors: Best Rohan , Nazifi Fatemeh , Cheng Han
Published: May 2024

Research on climate change mitigation has increasingly considered carbon pricing, with these efforts concentrating on reductions in carbon dioxide (CO2) emissions. Our comprehensive cross-country analysis extends this focus by quantitatively evaluating the effects of carbon pricing on four major pollutants: CO2, nitrous oxide (N2O), methane (CH4), and particulate matter (PM). We use regressions and introduce entropy balancing to this research area. Analyzing data from 132 countries from 1992 to 2019, we find that carbon pricing is associated with an average annual reduction in CO2 emissions by 3 percentage points. A one-unit increase in a coverage-weighted carbon price is associated with reductions in N2O emissions by approximately 0.1 percentage points. A shorter panel for 2010–2017 shows a larger impact of 0.3 percentage points for PM. These findings underline the efficacy of carbon pricing not just in curtailing CO2 but in significantly mitigating other harmful pollutants on a global scale. Reductions in pollutants beyond CO2 provide further motivation for policymakers to pursue carbon pricing.
Assessing the Potential for Electrification of the Food Industry and Its Implications for Environmental Sustainability
Authors: Jovet Yoann , Laurent Alexis , Lefevre Frédéric , Clausse Marc
Published: May 2024

Most studies on industrial heat decarbonization by electrification focus on energy and greenhouse gas emissions. However, there are additional potential environmental impacts to be considered to make a fair comparison. The aim of the proposed work is therefore to highlight the benefits and drawbacks of switching to electricity, using life cycle assessment (LCA) methodology to explore more environmental issues. In addition, in order to evaluate the environmental sustainability of this transformation, the LCA results are compared with sustainability thresholds defined with two different methods, on a global scale using the “sustainable levels” concept. The first method is based on the current environmental impacts of industrial processes, while the second considers the economic added value. Industrial heat production levels for the Danish and French food industries are used as case studies. The results show a large number of environmental trade-offs associated with electrification, some of which are leading to unsustainable levels. Sustainability thresholds based on economic added value ensure a fairer distribution between sectors, in particular by preventing the most virtuous sectors and processes from being penalized.
Power System State Estimation Based on Fusion of PMU and SCADA Data
Authors: Zhu Jiaming , Gao Wengen , Li Yunfei , Guo Xinxin , Zhang Guoqing , Sun Wanjun
Published: May 2024

This paper introduces a novel hybrid filtering algorithm that leverages the advantages of Phasor Measurement Units (PMU) to address state estimation challenges in power systems. The primary objective is to integrate the benefits of PMU measurements into the design of traditional power system dynamic estimators. It is noteworthy that PMUs and Supervisory Control and Data Acquisition (SCADA) systems typically operate at different sampling rates in power system estimation, necessitating synchronization during the filtering process. To address this issue, the paper employs a predictive interpolation method for SCADA measurements within the framework of the Extended Kalman Filter (EKF) algorithm. This approach achieves more accurate estimates, closer to real observation data, by averaging the KL distribution. The algorithm is particularly well-suited for state estimation tasks in power systems that combine traditional and PMU measurements. Extensive simulations were conducted on the IEEE-14 and IEEE-30 test systems, and the results demonstrate that the fused estimator outperforms individual estimators in terms of estimation accuracy.
Lignocellulosic Residues from Fruit Trees: Availability, Characterization, and Energetic Potential Valorization
Authors: Cavalaglio Gianluca , Fabbrizi Giacomo , Cardelli Filippo , Lorenzi Leonardo , Angrisano Mariarosaria , Nicolini Andrea
Published: May 2024

Reducing the carbon footprint of energy production is one of the most pressing challenges facing humanity today. Lignocellulosic biomass residues from fruit production industries show promise as a viable energy source. This paper presents a study of the Italian context concerning the utilization of orchard lignocellulosic residues for energy production as electricity or bioethanol. The potential of various orchard residues was assessed through chemical and physical analyses, and an equivalent electrical energy of about 6441.62 GWh or an amount of 0.48 Mt/y of bioethanol was obtained based on the average annual dry residue mass availability of about 3.04 Mt/y. These data represent 9.30% of the national electrical energy production from renewable sources, as well as 6.21% of the Italian demand for gasoline in 2022. Electricity generation from these residues has shown its potential as a reliable and sustainable baseload power source, as well as a source of renewable transportation fuel. The studied process could be a valuable reference to expand these concepts on a global scale to achieve a greener and more sustainable energy future.
Genetic Diversity and Population Structure of Bursaphelenchus xylophilus in Guangdong, Guangxi, and Jiangsu Provinces in China
Authors: Feng Yuan , Jian Wenjing , Ding Xiaolei , Ye Jianren
Published: May 2024

This study aimed to investigate the genetic structures of pine wood nematodes (PWNs, Bursaphelenchus xylophilus (Steiner & Buhrer) Nickle)), in Guangdong (GD), Guangxi (GX), and Jiangsu (JS) Provinces (the major PWN dispersal centers). Furthermore, we also explored potential migration routes among the different provinces in order to provide insights into the epidemic source of PWNs in the three provinces in China. We re-sequenced a total of 241 PWNs collected from the above provinces using next-generation sequencing to obtain raw genomic data. Bioinformatics analysis was used to identify the SNPs, genetic structures, and selective sweeps of the PWNs. The results indicate that the PWNs from these three provinces can be classified into five groups (A, B, C, D, and E), among which the genetic variations are significant. All PWN strains from JS were exclusively found in Group A. The PWNs in Groups B and C were composed of strains from GD and GX, while Groups D and E comprised only GD strains. Introgression analysis identified two possible pathways: (1) from Group A to Group B-GX and (2) from Group E to Group D. Selective sweep analysis showed that in Groups B and C, the candidate genes of Group B were mainly related to pectin lyase activity.