bluuebunny/crossref_metadata_2025 huggingface dataset:
Circular RNA PRKCI (hsa_circ_0067934): a potential target in the pathogenesis of human malignancies
Authors: Qiu Shipei , Zhang Kefan , Chen Siyu , Yin Shuting
Published: April 2024

Circular RNAs (circRNAs) are a new type of endogenous non-coding RNA formed by a covalent closed loop. CircRNAs are characterized by specificity, universality, conservation, and stability. They are abundant in eukaryotic cells and have biological regulatory roles at various transcriptional and post-transcriptional levels. The upregulation of circPRKCI has been observed in a variety of tumors and is directly related to the clinicopathological characteristics of tumors and prognosis. More importantly, circPRKCI can participate in the tumorigenesis, progression, recurrence, and metastasis of various tumors through many functional mechanisms, including the activation of signaling pathways, such as the phosphatidylinositol-3-kinase (PI3K)/AKT pathway, and sponging of many microRNAs (miRNAs). This review summarizes the progress achieved in understanding the biological functions of circRNA PRKCI in various tumors. The goal is to inform the discovery of more functional mechanisms and new anticancer molecular targets.
Is there any radiation-induced brachial plexopathy after hypofractionated postmastectomy radiotherapy with helical tomotherapy?
Authors: Chomchai Thinnakorn , Klunklin Pitchayaponne , Tongprasert Siam , Kanthawang Thanat , Toapichattrakul Piyapasara , Chitapanarux Imjai
Published: April 2024

Introduction

Radiation-induced brachial plexopathy (RIBP) is one of the most concerning late radiation effects after hypofractionated postmastectomy radiotherapy (HF-PMRT) to the chest wall and regional lymph nodes. The purpose of this study was to investigate the RIBP events occurring in breast cancer patients after HF-PMRT using intensity-modulated radiation therapy (IMRT) by helical tomotherapy. Furthermore, the dosimetric parameters of the ipsilateral brachial plexus were reported.

Materials and methods

Breast cancer patients who underwent HF-PMRT using the IMRT via HT at our institute were included. In the first cohort, subjective RIBP symptoms were measured using a QuickDASH questionnaire, whereas objective RIBP events were assessed using a comprehensive physical evaluation in the second cohort. The ipsilateral brachial plexus from all eligible patients’ treatment plans was contoured, and the dosimetric parameters were explored.

Results

From March 2014 to December 2022, 229 patients were enrolled; 107 and 72 individuals were in the first and second cohorts, respectively. The first cohort’s median follow-up period was 27 months, and the second cohort was 31 months. In the first cohort, 80 patients (74.77%) had a normal function, 21 (19.63%) had a mild grade, and 6 (5.61%) had a moderate grade; no severe or very severe RIBP was observed. However, the comprehensive physical evaluation of the second cohort indicated no RIBP events. Dosimetric analysis revealed that the median maximum dose was 44.52, 44.52, and 44.60 Gy; the median mean dose was 33.00, 32.23, and 32.33 Gy; and the median dose at 0.03 cc was 44.33, 44.36, and 44.39 Gy for all patients, patients in the first and second cohort, respectively. Each dosimetric parameter was evaluated, and no statistically significant differences were detected.

Conclusion

The absence of RIBP events supports the safety of employing HF-PMRT by HT for the chest wall and all regional lymph nodes. We propose that applying the ICRU Report 83 criteria for IMRT planning, which limit the maximum dose (107% of the prescribed dose) to less than 2% of the planning target volume and exclude the brachial plexus region from the maximal dose area, is a practical way to minimize the risk of RIBP from HF-PMRT.
Timing of intubation of pediatric hematopoietic cell transplant patients: an international survey
Authors: Hume Janet , Goertzen Lexie , Avent Yvonne , Steiner Marie E. , McArthur Jennifer ,   the Hematopoietic Cell Transplant and Cancer Immunotherapy subgroup of the Pediatric Acute Lung Injury and Sepsis Investigator’s Network (HCT-CI subgroup of PALISI)
Published: April 2024

Introduction

Retrospective data suggest that pediatric hematopoietic cell transplant (HCT) patients placed on non-invasive ventilation (NIV) prior to intubation have increased risk of mortality compared to patients who are intubated earlier in their course. The HCT-CI subgroup of the PALISI Network set out to gain a better understanding of factors that influence clinician’s decisions surrounding timing of intubation of pediatric HCT patients.

Methods

We validated and distributed a brief survey exploring potential factors that may influence clinician’s decisions around timing of intubation of pediatric HCT patients with acute lung injury (ALI).

Results

One hundred and four of the 869 PALISI Network’s members responded to the survey; 97 of these respondents acknowledged caring for HCT patients and were offered the remainder of the survey. The majority of respondents were PICU physicians (96%), with a small number of Advanced Practice Providers and HCT physicians. As expected, poor prognosis categories were perceived as a factors that delay timing to intubation whereas need for invasive procedures was perceived as a factor shortening timing to intubation. Concerns for oxygen toxicity or NIV-associated lung injury were not believed to influence timing of intubation.

Discussion

Our survey indicates increased risk of ALI from prolonged NIV and oxygen toxicity in HCT patients are not a concern for most clinicians. Further education of pediatric ICU clinicians around these risk factors could lead to improvement in outcomes and demands further study. Additionally, clinicians identified concerns for the patient’s poor prognosis as a common reason for delayed intubation.
A retrospective study on the correction of distal arthrogryposis with a progressive extension brace
Authors: Zhou Jiateng , Zhang Tong , Wang Zhibo , Li Dongdong , Wu Xin , Yu Qinyuan , Wang Bin
Published: April 2024

Purpose

Camptodactyly, clasped thumbs, and windblown hands are distinctive features of distal arthrogryposis (DA). Current therapeutic interventions often yield suboptimal effects, predisposing patients to relapses and complications. This study explicates a corrective approach involving a progressive extension brace for the management of DA and evaluates its clinical outcomes.

Methods

Between 2015 and 2023, progressive extension braces were used in 32 DA patients, with an average follow-up of 4.8 years. Patients were stratified by age into four groups: 0–1, 1–3, 3–7, and above 7 years. The correction of camptodactyly was assessed based on the total active movement (TAM) of metacarpophalangeal joints (MPJ) and proximal interphalangeal joints (PIPJ), as well as the extensor lag of PIPJ. Clasped thumb correction was evaluated by measuring the thumb-to-index finger metacarpal angle (M1M2 angle) and the degree of deviation at the first MPJ (M1P1 angle). The quality of life for the children was measured using PedsQL 4.0, while parental satisfaction was gauged using the FACE questionnaire.

Results

Earlier intervention with a progressive extension brace yielded superior corrective results. Infants aged 0–1 year and toddlers aged 1–3 years achieved average TAM scores of 152° and 126° after correction; however, patients older than 3 years experienced a significant decrease in TAM with the same treatment. Infants and toddlers with DA showed improvement in the average extensor lag from 46° to 6°. The M1M2 angle increased from an average of 38° to 65°, with the M1P1 angle decreasing from an average of 43° to 5°. After the treatment, average PedsQL scores of 94.7 (parent-reported) and 89.3 (child-reported) were achieved. Among the 32 parents, 24 expressed high satisfaction, 5 expressed moderate satisfaction, and 3 expressed fair satisfaction.

Conclusion

The early, progressive, and consistent use of an extension brace significantly improved joint mobility and corrected camptodactyly and clasped thumbs. It can be an effective approach to addressing hand deformities in patients with DA.
The first selective VAP-1 inhibitor in China, TT-01025-CL: safety, tolerability, pharmacokinetics, and pharmacodynamics of single- and multiple-ascending doses
Authors: Yang Yuanxun , Yu Lei , Sheng Zejuan , Lin Hui , Weng Zuyi , Song Wei , Cao Bei , Zhao Yu , Gao Yingsheng , Ni Shumao , Wang Huimin , Ma Tingting , Huang Lei , Sun Caixia , Li Juan
Published: April 2024

Introduction: TT-01025-CL is an oral, irreversible small molecule that potently inhibits vascular adhesion protein-1 (VAP-1) for the treatment of inflammation associated with non-alcoholic steatohepatitis (NASH). The objectives of this study were to evaluate the safety/tolerability, pharmacokinetics, and pharmacodynamics of TT-01025-CL, a VAP-1 inhibitor, in healthy Chinese volunteers.

Methods: Double-blind, placebo-controlled, dose-escalation studies were conducted in subjects randomized to receive oral once-daily TT-01025-CL (ranges: 10–300 mg [single dose]; 20–100 mg for 7 days [multiple doses]) or placebo under fasting conditions. Safety and tolerability were monitored throughout the study. Pharmacokinetic (PK) parameters were determined using non-compartment analysis. The activity of semicarbazide-sensitive amine oxidase (SSAO)-specific amine oxidase and the accumulation of methylamine in plasma were evaluated as pharmacodynamic (PD) biomarkers.

Results: A total of 36 (single-dose group) and 24 (multiple-dose group) subjects were enrolled in the study. No serious adverse events (AEs) were reported, and no subject discontinued due to an AE. All treatment-emergent adverse events (TEAEs) were mild and moderate in intensity. No dose-dependent increase in the intensity or frequency of events was observed. TT-01025-CL was rapidly absorbed after administration. In the single-ascending dose (SAD) study, median Tmax ranged from 0.5 to 2 h and mean t1/2z ranged from 2.09 to 4.39 h. PK was linear in the range of 100–300 mg. The mean Emax of methylamine ranged from 19.167 to 124.970 ng/mL, with mean TEmax ranging from 13.5 to 28.0 h. The complete inhibition (>90%) of SSAO activity was observed at 0.25–0.5 h post-dose and was maintained 48–168 h post-dose. In the multiple-ascending dose (MAD) study, a steady state was reached by day 5 in the 40 mg and 100 mg dose groups. Negligible accumulation was observed after repeated dosing. PK was linear in the range of 20–100 mg. Plasma methylamine appeared to plateau at doses of 20 mg and above, with mean Emax ranging from 124.142 to 156.070 ng/mL and mean TEmax ranging from 14.2 to 22.0 h on day 7. SSAO activity in plasma was persistently inhibited throughout the treatment period. No evident change in methylamine and SSAO activity was observed in the placebo groups.

Conclusion: TT-01025-CL was safe and well-tolerated at a single dose of up to 300 mg and multiple doses of up to 100 mg once daily for 7 consecutive days. Absorption and elimination occurred rapidly in healthy volunteers. Linearity in plasma exposure was observed. TT-01025-CL inhibited SSAO activity rapidly and persistently in humans. The profile of TT-01025-CL demonstrates its suitability for further clinical development.
Association between circadian syndrome and chronic diarrhea: a cross-sectional study of NHANES 2005–2010 data
Authors: Ding Liang , Duan Jinnan , Yang Tao , Jin Chaoqiong , Lv Shanmei , Ma Ahuo , Qin Yuehua
Published: April 2024

Background

Circadian rhythms are reported to influence physiological processes in the gastrointestinal system, but associations between circadian syndrome (Circs) and chronic diarrhea (CD) remain unclear. Here, we explored such relationships to provide new insights into CD management.

Methods

We conducted a cross-sectional retrospective analysis using the National Health and Nutrition Examination Survey (NHANES) data between 2005 and 2010. Univariate and multivariable logistic regression analyses were performed on weighted data to explore associations between Circs and CD.

Results

Results were presented using forest plots, odds ratios (ORs), and 95% confidence intervals (CIs). Data with p-values < 0.05 were considered statistically significant. In total, 5,661 US participants, of which 412 had CD (weighted percentage = 6.20%), were enrolled. In univariate logistic regression analyses, participants with Circs had a significantly higher risk of CD (OR = 1.51, 95% CI: 1.15–1.99). After adjusting for covariates, model 2 (OR = 1.40, 95% CI: 1.03–1.90) and model 3 (OR = 1.42, 95% CI: 1.01–2.00) data were consistent with model 1 data. Additionally, the number of Circs components was positively associated with CD in all three models. Subgroup analyses revealed an association between CD and Circs in participants who had high blood pressure (OR = 2.46, 95% CI: 1.48–4.11, p < 0.001).

Conclusion

In this cross-sectional study, we found that Circs is positively associated with the risk of CD in US adults, especially in those with high blood pressure. This association may provide new management strategies for CD.
The impact of mixed planting of Poaceae species in the Qinghai-Tibet plateau region on forage yield, soil nutrients, and soil microbial communities
Authors: Li Sida , Xiang Xuemei , Shi Zhenghai , Liu Wen-hui , Liang Guoling , Zhang Yongchao , Li Wen
Published: April 2024

Establishing cultivated grassland in the Qinghai-Tibet Plateau region is an effective method to address the conflict between vegetation and livestock. However, the high altitude, low temperature, and arid climate in the region result in slow regeneration and susceptibility to degradation of mixed cultivation grassland containing perennial legumes and gramineous plants. Therefore, we aim to through field experiments, explore the feasibility of establishing mixed cultivation grassland of Poaceae species in the region by utilizing two grass species, Poa pratensis L. and Puccinellia tenuiflora. By employing a mixture of P. pratensis and P. tenuiflora to establish cultivated grassland, we observed significant changes in forage yield over time. Specifically, during the 3rd to 6th years of cultivation, the yield in the mixed grassland was higher than in monocultures. It exceeded the yield of monoculture P. tenuiflora by 19.38% to 29.14% and surpassed the monoculture of P. pratensis by 17.18% to 62.98%. Through the analysis of soil physicochemical properties and soil microbial communities in the cultivated grassland, the study suggests that the mixed grassland with Poaceae species can enhance soil enzyme activity and improve soil microbial communities. Consequently, this leads to increased soil nutrient levels, enhanced nitrogen fixation efficiency, and improved organic phosphorus conversion efficiency. Therefore, establishing mixed grasslands with Poaceae species in the Qinghai-Tibet Plateau region is deemed feasible.
Effects of clonal fragmentation on Pyrrosia nuda depend on growth stages in a rubber plantation
Authors: Yu Xiaocheng , Jin Nan , Bai Rong , Mo Yuxuan , Pu Xiaoyan , Li Jingchao , Lu Hua-Zheng
Published: April 2024

Introduction

Clonal fragmentation helps to assess clonal plants' growth resilience to human and environmental disturbance. Although clonal integration in epiphytes in tropical rubber plantations is important to understand their role in enhancing biodiversity and ecosystem services, research on this subject is limited. These plantations are typically monospecific economic forests that face increased anthropogenic disturbances.

Methods

In this study, we selected the clonal fern Pyrrosia nuda to study its survival status, biomass, maximum quantum yield of photosystem II (Fv/Fm), and frond length in response to the level of clonal fragmentation in a tropical rubber plantation.

Results and discussion

The results showed that (1) clonal fragmentation significantly negatively affected the survival rate, biomass, and frond length of clonal plants, but with minimal effects on Fv/Fm at different growth stages; (2) the performance of a ramet (e.g., biomass or frond length) increased with ramet developmental ages and decreased with the number of ramets in a clonal fragment. The age-dependent impacts of clonal fragmentation provide insights into the biodiversity conservation of epiphytes and forest management in man-made plantations. Therefore, to better conserve the biodiversity in tropical forests, especially in environment-friendly rubber plantations, there is a need to reduce anthropogenic disturbances and alleviate the level of fragmentation.
Secular trends in physical growth, biological maturation, and intelligence in children and adolescents born between 1978 and 1993
Authors: Eichelberger Dominique A. , Chaouch Aziz , Rousson Valentin , Kakebeeke Tanja H. , Caflisch Jon , Wehrle Flavia M. , Jenni Oskar G.
Published: April 2024

Introduction

Human physical growth, biological maturation, and intelligence have been documented as increasing for over 100 years. Comparing the timing of secular trends in these characteristics could provide insight into what underlies them. However, they have not been examined in parallel in the same cohort during different developmental phases. Thus, the aim of this study was to examine secular trends in body height, weight, and head circumference, biological maturation, and intelligence by assessing these traits concurrently at four points during development: the ages of 4, 9, 14, and 18 years.

Methods

Data derived from growth measures, bone age as an indicator of biological maturation, and full-scale intelligence tests were drawn from 236 participants of the Zurich Longitudinal Studies born between 1978 and 1993. In addition, birth weight was analyzed as an indicator of prenatal conditions.

Results

Secular trends for height and weight at 4 years were positive (0.35 SD increase per decade for height and an insignificant 0.27 SD increase per decade for weight) and remained similar at 9 and 14 years (height: 0.46 SD and 0.38 SD increase per decade; weight: 0.51 SD and 0.51 SD increase per decade, respectively) as well as for weight at age 18 years (0.36 SD increase per decade). In contrast, the secular trend in height was no longer evident at age 18 years (0.09 SD increase per decade). Secular trends for biological maturation at 14 years were similar to those of height and weight (0.54 SD increase per decade). At 18 years, the trend was non-significant (0.38 SD increase per decade). For intelligence, a positive secular trend was found at 4 years (0.54 SD increase per decade). In contrast, negative secular trends were observed at 9 years (0.54 SD decrease per decade) and 14 years (0.60 SD decrease per decade). No secular trend was observed at any of the four ages for head circumference (0.01, 0.24, 0.17, and − 0.04 SD increase per decade, respectively) and birth weight (0.01 SD decrease per decade).

Discussion

The different patterns of changes in physical growth, biological maturation, and intelligence between 1978 and 1993 indicate that distinct mechanisms underlie these secular trends.
Low-rank human-like agents are trusted more and blamed less in human-autonomy teaming
Authors: Gall Jody , Stanton Christopher J.
Published: April 2024

If humans are to team with artificial teammates, factors that influence trust and shared accountability must be considered when designing agents. This study investigates the influence of anthropomorphism, rank, decision cost, and task difficulty on trust in human-autonomous teams (HAT) and how blame is apportioned if shared tasks fail. Participants (N = 31) completed repeated trials with an artificial teammate using a low-fidelity variation of an air-traffic control game. We manipulated anthropomorphism (human-like or machine-like), military rank of artificial teammates using three-star (superiors), two-star (peers), or one-star (subordinate) agents, the perceived payload of vehicles with people or supplies onboard, and task difficulty with easy or hard missions using a within-subject design. A behavioural measure of trust was inferred when participants accepted agent recommendations, and a measure of no trust when recommendations were rejected or ignored. We analysed the data for trust using binomial logistic regression. After each trial, blame was apportioned using a 2-item scale and analysed using a one-way repeated measures ANOVA. A post-experiment questionnaire obtained participants’ power distance orientation using a seven-item scale. Possible power-related effects on trust and blame apportioning are discussed. Our findings suggest that artificial agents with higher levels of anthropomorphism and lower levels of rank increased trust and shared accountability, with human team members accepting more blame for team failures.
Evidence-informed stakeholder consultations to promote rights-based approaches for children with disabilities
Authors: Shikako Keiko , Lai Jonathan , Yoo Paul Y. , Teachman Gail , Majnemer Annette
Published: April 2024

Purpose

To strengthen the translation of evidence to actionable policy, stakeholder engagement is necessary to synthesize, prioritize and contextualize the academic research content into accessible language. In this manuscript we describe a multi-level evidence-based stakeholder consultation process and related outcomes proposed to promote awareness of and foster cross-sectorial collaborations towards human rights-based approaches for children with disabilities.

Methods

Mixed-methods participatory action research done in three steps: (1) A literature review of peer-reviewed evidence on rights-based approaches in childhood disabilities; (2) Consultation with researchers in diverse fields, grassroot organizations, caregivers, and youth with disabilities; (3) A constructive dialogue with decision makers at federal and provincial levels in Canada to discuss consultations results.

Results

Stakeholders value human rights approaches that can have a direct impact on practical aspects of their daily living. Organizations give high importance to adopting rights-based approaches to measure policy outcomes, while parents value service provision and youth emphasize accessibility.

Conclusion

The implementation of rights-based approaches in childhood disabilities can support policy, services, and daily lives of children with disabilities and the ecosystems around them. It can also guide research priorities, and create a common language to foster collaborations across sectors and interested parties.
Elite Genotypes of Water Yam (Dioscorea alata) Yield Food Product Quality Comparable to White Yam (Dioscorea rotundata)
Authors: Adesokan Michael , Alamu Emmanuel Oladeji , Fawole Segun , Asfaw Asrat , Maziya-Dixon Busie
Published: April 2024

Water yam (Dioscorea alata), also known as winged yam, is one of the most economically significant yam species, serving as a staple food crop in tropical and subtropical regions. Its widespread cultivation is due to its favorable agronomic characteristics, including high yield, improved tuber storability, and significant nutritional and health benefits. Despite these advantages, water yam often remains underutilized due to consumer biases towards its traditional food product quality, particularly for pounded yam preparations. In this study, we evaluated fifty-eight improved genotypes of water yams grown across three locations to assess their potential to produce superior food qualities comparable to the widely consumed white yams (D. rotundata). Seven white yams, including popular landraces, were used to set thresholds for desirable food quality. Through standardized analysis, yam samples were assessed for their biochemical composition and culinary and sensory texture attributes. The results revealed varying ranges of dry matter (DM), starch, sugar, protein, crude fiber (CF), fat, and amylose, spanning from 20.35 to 35.95 g/100 g, 42.81 to 83.31 g/100 g, 4.76 to 6.95 g/100 g, 4.33 to 6.62 g/100 g, 1.55 to 3.89 g/100 g, 0.32 to 0.53 g/100 g, and 29.27 to 38.52 g/100 g, respectively. The mean values (±SD) were found to be 29.85 ± 4.0 g/100 g (DM), 67.90 ± 44g/100 g (starch), 5.82 ± 0.64 g/100 g (sugar), 6.31 ± 1.31 g/100 g (protein), 2.14 ± 0.57 g/100 g (crude fiber), 0.44 ± 0.08 (fat), and 33 ± 16.43 g/100 g (amylose). Significant effects (p < 0.001) of the planting environments and genotypes on the biochemical composition of the yam samples were observed, except for the sugar content. Furthermore, specific water yam genotypes, such as TDa 0900354, TDa 9801174, TDa 1401619, TDa 1400301, TDa 140091, TDa 0100029, TDa 1100793, TDa 1401249, TDa 1100242, and TDa 1401276, exhibited biochemical properties and culinary and sensory textural attributes akin to the improved white yam genotypes and their landrace counterparts. These findings underscore the potential for promoting selected water yam genotypes to diversify food options and reduce reliance on a limited array of crops, particularly in traditional food-insecure regions of tropical Africa.
Joint Hybrid Beamforming Design for Millimeter Wave Amplify-and-Forward Relay Communication Systems
Authors: Zhao Jinxian , Jiang Dongfang , Wei Heng , Liu Bingjie , Zhao Yifeng , Zhang Yi , Yu Haoyuan , Liu Xuewei
Published: April 2024

Hybrid beamforming (HBF) has been regarded as one of the most promising technologies in millimeter Wave (mmWave) communication systems. In order to guarantee the communication quality in non-line-of-sight (NLOS) scenarios, joint HBF design for the mmWave amplify-and-forward (AF) relay communication system is studied in this paper. The ideal case is first considered where the mmWave half-duplex (HD) AF relay system operates with channel state information (CSI) accurately known. In order to tackle the non-convex problem, a manifold optimization (MO)-based alternating optimization algorithm is proposed, where an optimization problem containing only constant modulus constraints in Euclidean space can be converted to an unconstrained optimization problem in a Riemann manifold. Furthermore, considering more practical cases with estimation errors of CSI, we investigate the robust joint HBF design with the system operating in full-duplex (FD) mode to obtain higher spectral efficiency (SE). A null-space projection (NP) based self-interference cancellation (SIC) algorithm is developed to attenuate the self-interference (SI). Different from the traditional SI suppression algorithm, there’s no limit on the number of RF chains. Numerical results reveal that our proposed algorithms has a good convergence and can effectively deal with the influence of different CSI estimation errors. A significant performance improvement can be achieved in contrast with other approaches.
Tribological Performance Study of Low-Friction PEEK Composites under Different Lubrication Conditions
Authors: Wu Shibo , Yan Zhijun , Sun Haocheng , Liu Ze , Xue Lixia , Sun Tao
Published: April 2024

This study introduces a low-friction composite based on PEEK to improve its friction and wear properties. The composite incorporates PTFE as a solid lubricant and utilizes PPTA as a reinforcing material within the PEEK matrix. These components were prepared utilizing a compression molding method, followed by a series of exploratory experiments to identify the optimal preparation conditions for PEEK. This research assesses how the PTFE/PPTA/PEEK composites perform in terms of friction and wear under dry and oil-lubricated conditions. By examining wear tracks using scanning electron microscopy and white light interference microscopy, this study aims to uncover the wear mechanisms of PEEK and its composites under different lubrication scenarios. Results show that the main wear mechanisms for the PTFE/PPTA/PEEK composites and bearing steel are ploughing and adhesive wear. The presence of PPTA helps reduce wear by leveraging its strong fibers and thermal stability, while the coefficient of friction decreases as PTFE creates a smooth, solid lubricating film on the surface. Notably, PEEK composites containing 25 wt% PTFE and 6 wt% PPTA demonstrate the lowest wear rates and reduced coefficient of friction in both dry and oil-lubricated conditions.
External Radiation Assistance of Neutrinoless Double Electron Capture
Authors: Kondratyev Vladimir N. , Karpeshin Feodor F.
Published: April 2024

The influence of electromagnetic radiation on nuclear processes is applied to an example of a neutrinoless double electron capture (0ν2ec). For cases with X-ray free-electron lasers (X-ray FELs) and/or inverse Compton X-ray sources, it was shown that such a decay can be significantly enhanced by tuning the system to the resonant conditions through the absorption and/or emission of a photon with the decay resonance defect energy Δ. In this case, the 0v2ec decay rate Γ2e of nuclide Z grew linearly with field intensity (S/Sz) up to the X-ray flux power Sm~Z6, while Sz~Z6 (Γ/Δ)2 with decay width Γ of a daughter atom. For the case of 78Kr → 78Se − 0ν2eL1L1 capture we find Sz~109 W cm−2 and Sm~1017 W cm−2 which indicate a possibility of increasing decay rate to eight orders of magnitude or even larger.
Toward Maximizing Assessment Efficiency: A Synthesized Trial-Based Functional Analysis and Competing Stimulus Assessment
Authors: Shawler Lesley A. , Castaneda-Velazquez Gabriella , Lafo Grace
Published: April 2024

Despite the success of the standard functional analysis (FA), some limitations to conducting an FA in practice include time, resources, ecological relevance, and safety, which have led to the development of procedural adaptations such as trial-based and synthesized FA formats. The purpose of this case study was to identify the function(s) of self-injurious behavior (SIB) for a 3-year-old female with developmental disabilities using a brief trial-based FA with ecologically relevant synthesized contingencies, based on caregiver input, to minimize opportunities for SIB. We identified that positive physical attention likely functioned, at least in part, as a reinforcer for SIB, in less than 42 min. Overall harm to the child as a result of the synthesized trial-based FA was minimal, and the caregiver viewed the modified conditions favorably. We then assessed the role of competing stimuli on SIB rates with the child’s mother and identified two potential items that may compete with attention as a reinforcer for SIB. Our findings highlight the utility and importance of individualized assessment as the first step in the safe treatment of severely challenging behavior.
Elevating Innovation: Unveiling the Twin Traction Method for a 50-Ton Load Capacity Elevator in Building and Construction Applications
Authors: Kim Gi-Young , Jang Seung-Ho
Published: April 2024

Most commercial elevators for buildings exceeding four stories use a cable-driven traction system. Typically, a single traction machine operates by hoisting the main cable on a traction sheave, thus vertically transporting the elevator car through rotational motion of the sheave. This research introduces a groundbreaking advancement aimed at elevating loading capacity to an unprecedented 50 tons—the highest known in the world. The innovation involves the development of a twin traction system, wherein two traction machines collaborate to lift the elevator. This novel elevator system has demonstrated remarkable capabilities, showcasing the ability to transport up to 300 passengers in a single trip. The installation of this high-capacity elevator system has yielded substantial improvements in construction work efficiency and safety protocols, particularly in scenarios where cranes are traditionally used. The newly developed elevator could lift 50 tons of equipment 60 times a day, whereas the crane was limited to 8 times. The positive impact on labor is also noteworthy, with increased safety and health considerations, especially in adverse weather conditions. By eliminating the need for manual stair climbing, the well-being of the workforce is prioritized. Furthermore, the heightened productivity resulting from a significant reduction in wait times for conventional elevators is a key outcome of this transformative technology. This research not only unveils a groundbreaking twin traction system but also highlights its multifaceted features in enhancing efficiency, safety, and overall productivity in various industries.
Study on Labor Productivity Improvement Based on Situational Awareness and Improved Value Stream Mapping
Authors: Jiang Lixuan , Shen Hongying , Zhang Jinhua
Published: April 2024

This study addresses the issue of poor construction labor productivity, exploring the process and methodology for increasing construction workers’ participation in labor productivity improvement, as well as a situational awareness (SA) development approach for construction workers based on lean construction (LC). A framework for enhancing labor productivity through SA has been developed. A case study approach is utilized to describe the LC improvement process, which includes enhancing construction workers’ SA for waste minimization and process optimization and engaging them in LC with improved value stream mapping (VSM). The labor productivity measurement approach, combined with VSM, is used to evaluate the labor productivity improvement with labor productivity improvement rate, resource efficiency, and flow efficiency. The results demonstrate that the labor productivity of the case project has increased by 24.07%, with 11.54% contributing resource efficiency and 88.46% contributing flow efficiency, indicating a greater increase in flow efficiency. This study fills a research gap in terms of the combination of construction workers’ SA enhancement and the involvement of LC practices to boost labor productivity. Furthermore, this study proposes an SA development approach based on LC at three levels: waste perception, VSM implementation, and labor productivity improvement assessment. This provides new perspectives for leveraging construction workers’ SA to increase labor productivity. The improved VSM approach and labor productivity measurements provide an operationalization of workers’ participation in continuous improvement. This research is of great practical relevance for augmenting the competencies of construction laborers and inspiring them to engage in labor productivity enhancement.
Harnessing Machine Learning to Unveil Emotional Responses to Hateful Content on Social Media
Authors: Louati Ali , Louati Hassen , Albanyan Abdullah , Lahyani Rahma , Kariri Elham , Alabduljabbar Abdulrahman
Published: April 2024

Within the dynamic realm of social media, the proliferation of harmful content can significantly influence user engagement and emotional health. This study presents an in-depth analysis that bridges diverse domains, from examining the aftereffects of personal online attacks to the intricacies of online trolling. By leveraging an AI-driven framework, we systematically implemented high-precision attack detection, psycholinguistic feature extraction, and sentiment analysis algorithms, each tailored to the unique linguistic contexts found within user-generated content on platforms like Reddit. Our dataset, which spans a comprehensive spectrum of social media interactions, underwent rigorous analysis employing classical statistical methods, Bayesian estimation, and model-theoretic analysis. This multi-pronged methodological approach allowed us to chart the complex emotional responses of users subjected to online negativity, covering a spectrum from harassment and cyberbullying to subtle forms of trolling. Empirical results from our study reveal a clear dose–response effect; personal attacks are quantifiably linked to declines in user activity, with our data indicating a 5% reduction after 1–2 attacks, 15% after 3–5 attacks, and 25% after 6–10 attacks, demonstrating the significant deterring effect of such negative encounters. Moreover, sentiment analysis unveiled the intricate emotional reactions users have to these interactions, further emphasizing the potential for AI-driven methodologies to promote more inclusive and supportive digital communities. This research underscores the critical need for interdisciplinary approaches in understanding social media’s complex dynamics and sheds light on significant insights relevant to the development of regulation policies, the formation of community guidelines, and the creation of AI tools tailored to detect and counteract harmful content. The goal is to mitigate the impact of such content on user emotions and ensure the healthy engagement of users in online spaces.
Fuel Price Networks in the EU
Authors: Gkatzoglou Fotios , Papadimitriou Theophilos , Gogas Periklis
Published: April 2024

This study deals with the evolution of fuels’ prices over time in the EU. The central research inquiry revolves around whether there exists any correlation among the trajectories followed by national prices in the gasoline and diesel markets. The EU, and more specifically the Euro-Area, by its construction, is treated as an OCA (Optimum Currency Area). In an OCA, certain conditions are met to ensure the smooth functioning of a common currency. The fuel price synchronization is essential because it contributes to the effective implementation of policies and promotes stability across the entire macroeconomy. The study covers the period of 2017–2022. For each type of fuel and year, we construct an individual network where network nodes represent the EU member states while the edges connecting these nodes represent strong temporal fuel price correlations among the member states. The properties of the resulting networks are analyzed within a Complex Network framework. Our goal is twofold: first, to detect any potential convergence or divergence in the trajectories of the prices, and second, to investigate the impact of tax and duty implementation on the co-movements of the prices. The empirical findings show that diesel markets have a more pronounced pattern of price co-movements compared to the gasoline markets. Moreover, the application of fuel taxation policies seems to adversely affect the co-movements of prices.
Industry 4.0 Transformation: Analysing the Impact of Artificial Intelligence on the Banking Sector through Bibliometric Trends
Authors: Manta Alina Georgiana , Bădîrcea Roxana Maria , Doran Nicoleta Mihaela , Badareu Gabriela , Gherțescu Claudia , Popescu Jenica
Published: April 2024

The importance of artificial intelligence in the banking industry is reflected in the speed at which financial institutions are adopting and implementing AI solutions to improve their services and adapt to new market demands. The aim of this research is to conduct a bibliometric analysis of the involvement of artificial intelligence in the banking sector to provide a comprehensive overview of the current state of research to guide future directions and support the sustainable development of this rapidly expanding field. Another important objective is to identify research gaps and underexplored areas in the field of artificial intelligence in banking. The methodology used is a bibliometric analysis using VOSviewer, analysing 1089 papers from the Web of Science database. The results of the study provide relevant information for banking professionals but also for policy makers. Thus, the study highlights key areas where banks are using artificial intelligence to gain competitive advantage, thereby guiding practitioners in strategic decision making. Moreover, by identifying emerging trends and patterns in AI adoption, the study helps banking practitioners with foresight, enabling them to anticipate and prepare for future developments in the field. In terms of governmental implications, the study can contribute to the development of more nuanced regulatory frameworks that effectively balance the promotion of AI innovation with the protection of ethical standards and consumer protection.
An In-Band Low-Radar Cross Section Microstrip Patch Antenna Based on a Phase Control Metasurface
Authors: Li Fang , Lv Miao , Wang Min , Jia Yongtao
Published: April 2024

An in-band low radar cross section (RCS) microstrip patch antenna based on a phase control metasurface is proposed. As the size of the phase control metasurface changes, it will have different phase adjustments to the incident electromagnetic wave. Two kinds of phase control metasurfaces with a 90° reflection phase difference are arranged in a checkerboard configuration and loaded above a microstrip array antenna. The metal of the microstrip array antenna can fully reflect the electromagnetic wave, so the incident wave passes through the metasurface again and forms a reflected wave with a phase difference of 180° ± 37° when passing through the phase control metasurfaces of different sizes. Thus, the microstrip array antenna can achieve in-band RCS reduction. The metamaterial forms a transmission window in the microstrip patch array antenna band to maintain the radiation performance. Finally, a reasonable agreement is obtained between the measured and simulated results.
Ontology-Driven Architecture for Managing Environmental, Social, and Governance Metrics
Authors: Yu Mingqin , Rabhi Fethi A. , Bandara Madhushi
Published: April 2024

The burgeoning significance of environmental, social, and governance (ESG) metrics in realms such as investment decision making, corporate reporting, and risk management underscores the imperative for a robust, comprehensive solution capable of effectively capturing, representing, and analysing the multifaceted and intricate ESG data landscape. Facing the challenge of aligning with diverse standards and utilising complex datasets, organisations require robust systems for the integration of ESG metrics with traditional financial reporting. Amidst this, the evolving regulatory landscape and the demand for transparency and stakeholder engagement present significant challenges, given the lack of standardized ESG metrics in certain areas. Recently, the use of ontology-driven architectures has gained attention for their ability to encapsulate domain knowledge and facilitate integration with decision-support systems. This paper proposes a knowledge graph in the ESG metric domain to assist corporations in cataloguing and navigating ESG reporting requirements, standards, and associated data. Employing a design science methodology, we developed an ontology that serves as both a conceptual foundation and a semantic layer, fostering the creation of an interoperable ESG Metrics Knowledge Graph (ESGMKG) and its integration within operational layers. This ontology-driven approach promises seamless integration with diverse ESG data sources and reporting frameworks, while addressing the critical challenges of metric selection, alignment, and data verification, supporting the dynamic nature of ESG metrics. The utility and effectiveness of the proposed ontology were demonstrated through a case study centred on the International Financial Reporting Standards (IFRS) framework that is widely used within the banking industry.
Research Progress and Prospect of Condition Assessment Techniques for Oil–Paper Insulation Used in Power Systems: A Review
Authors: Jiang Zaijun , Li Xin , Zhang Heng , Zhang Enze , Liu Chuying , Fan Xianhao , Liu Jiefeng
Published: April 2024

Oil–paper insulation is the critical insulation element in the modern power system. Under a harsh operating environment, oil–paper insulation will deteriorate gradually, resulting in electrical accidents. Thus, it is important to evaluate and monitor the insulation state of oil–paper insulation. Firstly, this paper introduces the geometric structure and physical components of oil–paper insulation and shows the main reasons and forms of oil–paper insulation’s degradation. Then, this paper reviews the existing condition assessment techniques for oil–paper insulation, such as the dissolved gas ratio analysis, aging kinetic model, cellulose–water adsorption isotherm, oil–paper moisture balance curve, and dielectric response technique. Additionally, the advantages and limitations of the above condition assessment techniques are discussed. In particular, this paper highlights the dielectric response technique and introduces its evaluation principle in detail: (1) collecting the dielectric response data, (2) extracting the feature parameters from the collected dielectric response data, and (3) establishing the condition assessment models based on the extracted feature parameters and the machine learning techniques. Finally, two full potential studies are proposed, which research hotspots’ oil–paper insulation and the electrical–chemical joint evaluation technique. In summary, this paper concludes the principles, advantages and limitation of the existing condition assessment techniques for oil–paper insulation, and we put forward two potential research avenues.
Structural Investigation of Orthoborate-Based Electrolytic Materials for Fuel Cell Applications
Authors: Milewski Jarosław , Ryś Piotr , Krztoń-Maziopa Anna , Żukowska Grażyna , Majewska Karolina , Zybert Magdalena , Kowalczyk Jacek , Siekierski Maciej
Published: April 2024

The paper presented delivers the proof for one of the possible solutions to the so-called medium-temperature gap—the lack of electrolytic systems able to efficiently work in a temperature range spanning from 200 to 450 °C. Regardless of the progress made in this field, the commercially available systems are still operating either at close to ambient temperatures, where hydrogen purity requirements are a significant limit, or above ca. 600 °C, where they suffer from increased corrosion and excessive thermal stresses occurring during startup and shutdown. Alkali metal orthoborates (M3BO3 M = Li, Na, K, or the mixture of these), in contrast to commercially used tetra-(M2B4O7) and meta-(MBO2) borates of these metals, are compounds with relatively poorly understood structure and physicochemical properties. The possibility of their application as an electrolyte in a fuel cell is a relatively new idea and has been preliminary reported. Therefore, an extended phase-focused analysis of the materials applied was needed to re-optimize both the synthetic strategy and the application route. Results of PXRD and FT-IR investigations showed, on the one hand, a complicated multi-phase structure, including the main orthoborate phase, as well as the presence of additional borate-based phases, including boric oxoacid. On the other hand, DTA tests proved not only that their melting temperatures are lower than these characteristics for the tetra- and meta-counterparts, but also that cation mixing leads to a subsequent decrease in this important functional parameter of the materials studied.