bluuebunny/crossref_metadata_2025 huggingface dataset:
Sexual Function and Metabolic/Hormonal Changes in Women Using Long-Term Hormonal and Non-Hormonal Contraceptives: A pilot study.
Authors: Moreira Igor Fernando de aquino , Bianchini Maria Passos , Moreira Gabrielle Rodrigues Campos , Almeida Alessandra Maciel , Rezende Bruno Almeida
Published: October 2020

Background: Female sexual dysfunction is a common condition that negatively impacts the emotional health and quality of life of the affected individuals. Long-acting reversible contraceptives (LARCs) are becoming increasingly popular due to their effectiveness and convenience. LARCs can be hormonal (etonogestrel releasing implant—ENG and Levonorgestrel intrauterine system—LNG) or non-hormonal (copper intrauterine device—CuIUD and copper-silver intrauterine device—SIUD). There are very few studies that assess the influence on LARCS on sexual function are lacking. This study aimed to assess changes in sexual function as well as metabolic and hormonal parameters in women after implantation with LARCs.
Methods: In this prospective cohort study, we assessed 80 women who visited the Military Police Hospital in Brazil for LARCs placement. The study participants were divided into 4 groups according to the type of LARC received: ENG n=17; LNG n=22, CuIUD n=18 and SIUD n=23. The four groups were evaluated twice (prior to LARC placement and approximately 3 months later) for sexual function, using the Female Sexual Function Index (FSFI) and Female Sexual Quotient (QS-F) questionnaires. Metabolic and hormonal parameters were also assessed using blood tests.
Results: ENG worsened sexual function according to FSFI and QS-F, across all domains. A decrease in sex hormone-binding globulin (SHBG) between stages was observed for all groups. We observed an improvement in sexual function for non-hormonal LARCs, specially SIUD. However this improvement was not statistically significant.
Conclusion: The use of non-hormonal LARCS improved sexual function. Etonogestrel implants, had a negative influence on sexual function, probably by blocking ovarian function, and thus reducing the production of androgens and estrogens.
Successful outcome of disseminated candida tropicalis osteomyelitis on remission induction for childhood Philadelphia chromosome–positive acute lymphoblastic leukemia
Authors: Xie Lichun , Long Qingling , Zhou Guichi , Liu Si-xi , Wen Feiqiu
Published: October 2020

Invasive fungal infection (IFI) is one of the most challenging complications in children with acute lymphoblastic leukemia (ALL) treatment, but acute fungal osteomyelitis (OM) is rarely encountered. Here, we describe a case of Candida tropicalis osteomyelitis in a 10-year-old patient with Philadelphia chromosome (Ph)–positive ALL. He was on remission induction therapy at the time of neutropenia, and abscess developed in the right arm. The blood and bone cultures were positive for Candida tropicalis. Antibiotics and anti-fungal were started. A magnetic resonance of the arm reveal in intraosseous abscess, suggestive of OM. Surgical irrigation and debridement of the bone were performed immediately. The patient was effectively treated with antifungal therapy and ALL treatment. Now he is full recovery, having complete clinical remission but with sequelae visible by MRI. He is taking oral posaconazole for consolidation until disappearance of the lesion shadows on MRI and having subsequent cycles of chemotherapy in parallel. The recommended treatment for candida osteomyelitis in Ph-positive ALL patients is fungicidal agent combined with surgery and modification chemotherapy with dasatinib. Using combined modalities of treatment seem to be crucial in the successful management of Ph-positive ALL.
A Survey on Generative Adversarial Networks for imbalance problems in computer vision tasks
Authors: Sampath Vignesh , Maurtua Iñaki , Martín Juan José Aguilar , Gutierrez Aitor
Published: October 2020

Any computer vision application development starts off by acquiring images and data, then preprocessing and pattern recognition steps to perform a task. When the acquired images are highly imbalanced and not adequate, the desired task may not be achievable. Unfortunately, the occurrence of imbalance problems in acquired image datasets in certain complex real-world problems such as anomaly detection, emotion recognition, medical image analysis, fraud detection, metallic surface defect detection, disaster prediction, etc., are inevitable. The performance of computer vision algorithms can significantly deteriorate when the training dataset is imbalanced. In recent years, Generative Adversarial Networks (GANs) have gained immense attention by researchers across a variety of application domains due to their capability to model complex real-world image data. It is particularly important that GANs can not only be used to generate synthetic images, but also its fascinating adversarial learning idea showed good potential in restoring balance in imbalanced datasets. In this paper, we examine the most recent developments of GANs based techniques for addressing imbalance problems in image data. The real-world challenges and implementations of synthetic image generation based on GANs are extensively covered in this survey. Our survey first introduces various imbalance problems in computer vision tasks and its existing solutions, and then examine key concepts such as deep generative image models and GANs. After that, we propose a taxonomy to summarize GANs based techniques for addressing imbalance problems in computer vision tasks into three major categories: 1. Image level imbalances in classification, 2. object level imbalances in object detection and 3. pixel level imbalances in segmentation tasks. We elaborate the imbalance problems of each group, and further provide GANs based solutions in each group. Readers will understand how GANs based techniques can handle the problem of imbalances and boost performance of the computer vision algorithms.
Ex vivo porcine model study on the treatment outcomes of scissor-type knife versus needle-type knife in endoscopic submucosal dissection performed by trainees
Authors: Ichijima Ryoji , Esaki Mitsuru , Yamakawa Shun , Minoda Yosuke , Suzuki Sho , Kusano Chika , Ikehara Hisatomo , Gotoda Takuji
Published: October 2020

Back ground
Endoscopic submucosal dissection (ESD) for gastrointestinal neoplasms can be technically difficult for trainee endoscopists. Presently, there is no consensus for trainees to select the endo-knife type in ESD. Therefore, we conducted a comparison study of treatment outcomes between scissors-type and needle-type knives in ESD performed by trainees in an ex vivo porcine model.
Methods
This study was conducted on trainee endoscopists who participated in ESD hands-on seminars held in August 2018 and September 2019 . A total of 22 trainees from 13 institutions were divided into two groups according to their endoscopic experience. Under expert supervision, each trainee performed two ESDs in porcine models, namely, scissor-type knife (ESD-S) and needle-type knife (ESD-N). The efficacy and safety, including the procedure time and rates of self-completion, en bloc resection, and complications, were compared between ESD-S and ESD-N. In subgroup analysis, we also investigated the predictors associated with the difficulty of ESD for trainees using multivariate logistic regression analysis .
Results
Eight trainees had an experience of over 1,000 endoscopies (senior trainee: S-Trainee), whereas the others had an experience of less than 1,000 endoscopies (junior trainee: J-Trainee). Among the S-Trainees, no significant differences were observed in any treatment outcome between ESD-S and ESD-N. Among the J-Trainees, the total procedure and mucosal incision times were significantly shorter in ESD-S than in ESD-N [total procedure time: 16.5 min (range: 10.0–31.0) vs. 22.3 min (range: 10.0–38.0), P = 0.018; circumferential incision time: 10.0 min (range: 6-16) vs. 17.0 min (range: 5.0–31.5); P = 0.019]. Regarding complications, muscular injury occurred in two patients during ESD-N performed by J-Trainees; however, no muscular injury occurred during ESD-S. In subgroup analysis, ESD-N was an independent predictive factor of difficult ESD (odds ratio 5.28, 95% confidence interval 1.25 –22.30; p = 0.024).
Conclusions
This study revealed that trainees, particularly those who have experienced less than 1,000 endoscopies, should opt for the scissor-type knife to perform ESD.
Comparison of modified Mohr–Coulomb model and Bai–Wierzbicki model for constructing 3D ductile fracture envelope of AA6063
Authors: Gao Jianye , He Tao , Huo Yuanming , Song Miao , Yao Tingting , Yang Wanbo
Published: October 2020

The 3D ductile fracture envelope of AA6063-T6 were developed to predict and prevent its fracture. Smooth round bar tension tests were performed to characterize the flow stress, and a series of experiments were conducted to characterize the ductile fracture firstly, such as notched round bar tension tests, compression tests and torsion tests. These tests cover a wide range of stress triaxiality (ST) and Lode parameter (LP) to calibrate the ductile fracture criterion. Plasticity modeling was performed, and the predicted results were compared with corresponding experimental data to verify the plasticity model after these experiments. Then the relationship between ductile fracture strain and ST with LP was constructed using the modified Mohr–Coulomb (MMC) model and Bai-Wierzbicki (BW) model to develop the 3D ductile fracture envelope. Finally, two ductile damage models were proposed based on 3D fracture envolope of AA6063. Through the comparison of the two models, it was found that BW model had better fitting effect, and the sum of squares of residual error of BW model was 0.9901. The two models had relatively large errors in predicting the fracture strain of SRB tensile test and torsion test, but both of the predicting error of both two models were within the acceptable range of 15%. In the process of finite element simulation, the evolution process of ductile fracture can be well simulated by the two models. However, BW model can predict the location of fracture more accurately than MMC model.
An SDF-1α gene-activated collagen scaffold restores pro-angiogenic wound healing features in human diabetic adipose-derived stem cells
Authors: Laiva Ashang Luwang , O’Brien Fergal J. , Keogh Michael B.
Published: October 2020

Background

Diabetic foot ulcer is one of the leading causes of leg amputation and mortality in diabetic patients. Autologous stem cell therapy holds some potential to be a solution to this problem, however diabetic stem cells are relatively dysfunctional and restrictive in their wound healing abilities. This study sought to explore if a novel collagen-chondroitin sulfate (coll-CS) scaffold functionalized with polyplex nanoparticles carrying the gene encoding for stromal-derived factor-1 alpha (SDF-1α gene-activated scaffold) can enhance the regenerative functionality of human diabetic adipose-derived stem cells (ADSCs).

Methods

Gene-activated scaffolds were first prepared by soak-loading polyethyleneimine nanoparticles carrying the plasmid encoding for SDF-1α gene into a freeze-dried coll-CS scaffold. ADSCs from healthy and diabetic donors were then seeded on the gene-activated scaffold. The response of the ADSCs in the gene-activated scaffold was then compared against those of the healthy ADSCs cultured on the gene-free scaffold over 2 weeks period. Functional response in the ADSCs such as the activation of SDF-1α mediated signaling, production of bioactive factors, pro-angiogenic bioactivity of secreted factors, matrix deposition and remodeling was determined using proteome profiling, Matrigel assay, qRT-PCR and immunofluorescence.

Results

Overall, we found that SDF-1α gene-activated scaffold could restore pro-angiogenic regenerative response in the human diabetic ADSCs similar to the healthy ADSCs on the gene-free scaffold. Gene and protein expression analysis revealed that the SDF-1α gene-activated scaffold induced the overexpression of SDF-1α in diabetic ADSCs and engaged the receptor CXCR7, causing downstream signaling of β-arrestin as effectively as the transfected healthy ADSCs. The transfected diabetic ADSCs also effectively stimulated angiogenesis in endothelial cells while undergoing matrix remodeling characterized by reduction in deposition of fibronectin matrix and increase in the expression of basement membrane protein collagen IV. The SDF-1α gene-activated scaffold also induced a controlled pro- healing response in the healthy ADSCs by disabling the signaling of early developmental factors while promoting the expression of tissue remodeling components.

Conclusion

We show that the SDF-1α gene-activated scaffold can overcome the deficiencies associated with diabetic ADSCs paving the way for autologous patient stem cell therapies in combination with novel biomaterials to treat diabetic foot ulcers.
Impact of problem formulations, pipe selection methods, and optimization algorithms on the rehabilitation of water distribution systems
Authors: Wang Qi , Huang Wen , Yang Xueqiang , Wang Libing , Wang Zhihong , Wang Yuanjian
Published: October 2020

Given the continuous aging of pipeline infrastructure buried underground, water utilities need to make a strategic plan on how to maintain the entire water distribution systems (WDSs) to ensure the required standard of supply. This paper investigates the nexus of three key factors that have a significant impact on the decision-making process of the rehabilitation plan for WDSs. The factors considered include the problem formulations, the pipe selection methods for identifying critical components of WDSs, and the multi-objective evolutionary algorithms (MOEAs). The nexus was revealed by considering all the combinations of two variants for each factor. The optimal rehabilitation problem of the Exeter network was used as a case study. Results exhibit that the problem formulation determined the range of Pareto fronts essentially, which should give the highest priority in the decision-making process. The pipe selection method played a secondary role, mainly affecting the shape of Pareto fronts. Optimization algorithms also had a considerable impact on the optimality of solutions, subject to their characteristics and parameter settings. This paper also highlights that breakthroughs need to focus on these key factors to facilitate a more cost-effective solution to the rehabilitation of large WDSs.
GPCC catalyzed hydrogen peroxide for decolorization of C.I. Reactive Red 24 from simulated dyeing wastewater
Authors: Wang Jie , Wang Xueyan
Published: October 2020

A kind of gelatin protein copper complex (GPCC for short) was synthesized by us. GPCC acting as catalyst was applied to catalyzed hydrogen peroxide for decolorization of C.I. Reactive Red 24 from simulated dyeing wastewater. The influence of catalyzed hydrogen peroxide by GPCC on the decolorization of C.I. Reactive Red 24 from simulated dyeing wastewater was discussed. The optimum decolorization technology condition was optimized. And the effect of salt on decolorization of C.I. Reactive Red 24 in this catalytic system was also investigated. The results showed that hydrogen peroxide can be catalyzed by GPCC. In the catalytic system, the structure of C.I. Reactive Red 24 can be degraded and a high decolorization rate can be obtained in a wide pH range. In addition, the decolorization percentage and decolorization rate will be further improved when salt is present in the catalytic system.
Una revisión funcional al recurso de anulación de laudo en el Perú
Authors: Reggiardo Mario
Published: October 2020

En el presente artículo, el Profesor Mario Reggiardo apoyándose en doctrina y jurisprudencia analiza las normas que regulan el recurso de anulación de un laudo arbitral. El autor evalúa las aproximaciones dogmáticas sobre si el recurso de anulación es un medio impugnatorio o un proceso impugnatorio.
Mi otro yo: La doctrina del álter ego y el artículo 14 de la Ley peruana de Arbitraje
Authors: Repetto Jose Luis , Hundskopf Andrés , Valderrama Miguel
Published: October 2020

En el presente artículo, los autores comentan la teoría del álter ego a la luz del artículo 14 de la ley peruana de arbitraje. Indican cuáles son los requisitos que la doctrina y la jurisprudencia arbitral han establecido para levantar el velo societario en sede arbitral. Asimismo, analizan un caso en el que se aplicó esta teoría y narran la odisea por la que tuvo que atravesar este laudo en el Poder Judicial peruano.
Inovasi media pembelajaran game edukasi berbasis visual basic pada mata pelajaran pendidikan kewarganegaraan
Authors: Pratiwi Emy Yunita Rahma , Siswanto Muhammad Bambang Edi
Published: October 2020

Pada umumnya peserta didik merasa enggan untuk mempelajari pendidikan kewarganegaraan. Beberapa problematikanya adalah pembelajaran pendidikan kewarganegaraan yang cenderung tidak menarik, membosankan, kekeliruan mahasiswa dalam memaknai dan memahami nilai-nilai yang terkandung dalam pendidikan kewarganegaraan, terbatasnya waktu yang digunakan untuk membuat media pembelajaran, kurangnya keterampilan yang dimiliki dalam membuat media pembelajaran berbasis TIK, dan tidak tersedianya biaya. Oleh karena itu, perlu adanya upaya untuk meningkatkan pembelajaran pendidikan kewarga-negaraan. Tujuan penelitian ini adalah untuk menghasilkan suatu media yang siap untuk diisi konten dan skenario penggunaanya, sehingga menjadi media yang menarik dan dapat meningkatkan motivasi belajar mahasiswa. Metode penelitian ini berbentuk kuantitatif dan kualitatif. Data kuantitatif data yang diperoleh dengan menggunakan kuesioner atau angket, sedangkan data kualitatif berupa: 1.) Data awal mengenai hasil observasi dan wawancara dengan dosen mata kuliah pendidikan kewarganegaraan terhadap pelaksanaan pembelajaran di kelas; dan 2.) Data komentar dan saran dari para validator. Target capaian dalam penelitian ini adalah untuk menghasilkan produk berupa media pembelajaran game edukasi dengan Microsoft Power Point berbasis Visual Basic pada mata pelajaran pendidikan kewarganegaraan yang digunakan untuk meningkatkan proses pem-belajaran maupun kompetensi peserta didik. AbstractIn general, students feel reluctant to study civic education. Some of the problems are civic education learning which tends to be unattractive, boring, student mistakes in interpreting and understanding the values contained in civic education, limited time spent making learning media, lack of skills in making ICT-based learning media, unavailability cost. Therefore, there is a need for efforts to improve civic education learning. The purpose of this research is to produce a media that is ready to be filled with content and scenarios for its use so that it becomes an attractive medium and can increase student motivation to learn. This research method is quantitative and qualitative. Quantitative data are data obtained using a questionnaire/questionnaire. While the qualitative data is in the form of 1) preliminary data regarding the results of observations and interviews with lecturers of civic education courses on the implementation of learning in class, 2) data on comments and suggestions from the validators. The target of the achievement is to produce a product in the form of learning media for educational games with Visual Basic-Based Microsoft PowerPoints in citizenship education subjects that are used to improve the learning process and the competence of students.
Use of Patient-Reported Symptoms from an Online Symptom Tracking Tool for Dementia Severity Staging: Development and Validation of a Machine Learning Approach
Authors: Shehzad Aaqib , Rockwood Kenneth , Stanley Justin , Dunn Taylor , Howlett Susan E
Published: October 2020

Background

SymptomGuide Dementia (DGI Clinical Inc) is a publicly available online symptom tracking tool to support caregivers of persons living with dementia. The value of such data are enhanced when the specific dementia stage is identified.

Objective

We aimed to develop a supervised machine learning algorithm to classify dementia stages based on tracked symptoms.

Methods

We employed clinical data from 717 people from 3 sources: (1) a memory clinic; (2) long-term care; and (3) an open-label trial of donepezil in vascular and mixed dementia (VASPECT). Symptoms were captured with SymptomGuide Dementia. A clinician classified participants into 4 groups using either the Functional Assessment Staging Test or the Global Deterioration Scale as mild cognitive impairment, mild dementia, moderate dementia, or severe dementia. Individualized symptom profiles from the pooled data were used to train machine learning models to predict dementia severity. Models trained with 6 different machine learning algorithms were compared using nested cross-validation to identify the best performing model. Model performance was assessed using measures of balanced accuracy, precision, recall, Cohen κ, area under the receiver operating characteristic curve (AUROC), and area under the precision-recall curve (AUPRC). The best performing algorithm was used to train a model optimized for balanced accuracy.

Results

The study population was mostly female (424/717, 59.1%), older adults (mean 77.3 years, SD 10.6, range 40-100) with mild to moderate dementia (332/717, 46.3%). Age, duration of symptoms, 37 unique dementia symptoms, and 10 symptom-derived variables were used to distinguish dementia stages. A model trained with a support vector machine learning algorithm using a one-versus-rest approach showed the best performance. The correct dementia stage was identified with 83% balanced accuracy (Cohen κ=0.81, AUPRC 0.91, AUROC 0.96). The best performance was seen when classifying severe dementia (AUROC 0.99).

Conclusions

A supervised machine learning algorithm exhibited excellent performance in identifying dementia stages based on dementia symptoms reported in an online environment. This novel dementia staging algorithm can be used to describe dementia stage based on user-reported symptoms. This type of symptom recording offers real-world data that reflect important symptoms in people with dementia.
Effective Control of COVID-19 in South Korea: Cross-Sectional Study of Epidemiological Data
Authors: Jeong Gwang Hun , Lee Hyo Jeong , Lee Jinhee , Lee Jun Young , Lee Keum Hwa , Han Young Joo , Yoon Sojung , Ryu Seohyun , Kim Da Kyung , Park Myung Bae , Yang Jae Won , Effenberger Maria , Eisenhut Michael , Hong Sung Hwi , Kronbichler Andreas , Ghayda Ramy Abou , Shin Jae Il
Published: October 2020

Background

South Korea is one of the few countries that has succeeded in flattening the curve of new COVID-19 cases and avoiding a second outbreak by implementing multiple strategies, ranging from an individual level to the population level.

Objective

We aim to discuss the unique strategies and epidemiological characteristics of COVID-19 in South Korea and present a summary of policies implemented by the Korean government during the COVID-19 pandemic.

Methods

We designed a cross-sectional study of epidemiological data published by the Korea Centers for Disease Control and Prevention on October 1, 2020. We analyzed detailed epidemiological information of COVID-19 cases, including the number of confirmed cases and resulting deaths.

Results

As of October 1, 2020, a total of 23,889 confirmed COVID-19 cases and 415 deaths were reported in South Korea. In this paper, we present data on the epidemiological characteristics and transmission of the disease and discuss how the South Korean government, health care providers, and society responded to the COVID-19 outbreak.

Conclusions

Understanding the epidemiological characteristics of COVID-19 in South Korea and the government’s successful efforts in managing the spread of the disease can provide important insights to other countries dealing with the ongoing pandemic.
Searching PubMed to Retrieve Publications on the COVID-19 Pandemic: Comparative Analysis of Search Strings
Authors: Lazarus Jeffrey V , Palayew Adam , Rasmussen Lauge Neimann , Andersen Tue Helms , Nicholson Joey , Norgaard Ole
Published: October 2020

Background

Since it was declared a pandemic on March 11, 2020, COVID-19 has dominated headlines around the world and researchers have generated thousands of scientific articles about the disease. The fast speed of publication has challenged researchers and other stakeholders to keep up with the volume of published articles. To search the literature effectively, researchers use databases such as PubMed.

Objective

The aim of this study is to evaluate the performance of different searches for COVID-19 records in PubMed and to assess the complexity of searches required.

Methods

We tested PubMed searches for COVID-19 to identify which search string performed best according to standard metrics (sensitivity, precision, and F-score). We evaluated the performance of 8 different searches in PubMed during the first 10 weeks of the COVID-19 pandemic to investigate how complex a search string is needed. We also tested omitting hyphens and space characters as well as applying quotation marks.

Results

The two most comprehensive search strings combining several free-text and indexed search terms performed best in terms of sensitivity (98.4%/98.7%) and F-score (96.5%/95.7%), but the single-term search COVID-19 performed best in terms of precision (95.3%) and well in terms of sensitivity (94.4%) and F-score (94.8%). The term Wuhan virus performed the worst: 7.7% for sensitivity, 78.1% for precision, and 14.0% for F-score. We found that deleting a hyphen or space character could omit a substantial number of records, especially when searching with SARS-CoV-2 as a single term.

Conclusions

Comprehensive search strings combining free-text and indexed search terms performed better than single-term searches in PubMed, but not by a large margin compared to the single term COVID-19. For everyday searches, certain single-term searches that are entered correctly are probably sufficient, whereas more comprehensive searches should be used for systematic reviews. Still, we suggest additional measures that the US National Library of Medicine could take to support all PubMed users in searching the COVID-19 literature.
PENGARUH MODEL PEMBELAJARAN PICTURE AND PICTURE TERHADAP KEMAMPUAN MENULIS NASKAH DRAMA SATU BABAK
Authors: Nainggolan Epitamala , Purwanto Petrus , Waruwu Ermina
Published: October 2020

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran picture and picture terhadap menulis naskah drama pada siswa kelas VIII. Model picture and picture merupakan model yang dapat mendorong siswa lebih kreatif dan aktif dalam proses pembelajaran. Metode yang digunakan adalah metode eksperimen, dengan model post-test only control design. Pengolahan data diperoleh hasil post-test kelas kontrol dengan nilai rata-rata 75,833 standar deviasi 8,461, standar error 1,562 dan kelas eksperimen nilai rata-rata 82,66, standar deviasi 6,914 standar error 1,284. Hasil perhitungan normalitas kelas kontrol memperoleh harga Lhitung < Ltabel sebesar 0,1321< 0,1617dan kelas eksperimen memperoleh harga Lhitung < Ltabel sebesar 0,1446<0,1617. Ini membuktikan bahwa kedua data tersebut berdistribusi normal. Hasil perhitungan homogenitas memperoleh harga Lhitung < Ltabel sebesar 1,481<1,858. Hal ini membuktikan sampel berasal dari populasi yang homogen. Hasil perhitungan hipotesis memperolah harga Thitung > Ttabel sebesar 3,531>2,002, maka hipotesis nihil (H0) ditolak dan hipotesis alternatif (Ha) diterima. Diperoleh kesimpulan terdapat pengaruh yang signifikan dengan penggunaan model pembelajaran picture and picture terhadap kemampuan menulis naskah drama satu babak pada siswa kelas VIII tahun pembelajaran 2018/2019.
KAJIAN KEEFEKTIVITAS KALIMAT KARYA MAHASISWA PRODI KESEHATAN MASYARAKAT FAKULTAS ILMU-ILMU KESEHATAN UHAMKA
Authors: Hasanudin Dede , Andayani Praptiningsih Novi
Published: October 2020

Penelitian ini bertujuan untuk mengkaji salah satu aspek ketatabahasaan yaitu aspek sintaksis dalam hal ini efektivitas kalimat dalam karya ilmiah yang dibuat oleh mahasiswa prodi kesmas Fikes Uhamka sebagai tugas akhir suatu mata kuliah bahasa Indonesia. Adapun aspek-aspek yang dinilai terbagi menjadi dua kategori yaitu mengenai penggunaan Ejaan yang Disempurnakan (dalam hal ini memanfaatkan PUEBI), meliputi aspek : 1) kesalahan penggunaan huruf, 2) kesalahan penggunaan tanda baca, 3) kesalahan penggunaan gabungan kata. Sementara untuk aspek sintaksis adalah tentang keefektifan kalimat yangdigunakan oleh mahasiswa meliputi: logika berpikir, 2) kehematan, 3) keparalelan, 4) keterpaduan interkalimat dan antarkalimat. Metode yang digunakan dalam penelitian ini adalah penelitian kualitatif dengan menggunakan Teknik analisis isi. Data yang diperoleh sesuai dengan fakta yang ada di dalam makalah mahasiswa yang dijadikan sampel dalam penelitian ini. Hasil penelitian dapat disimpulkan sebagai berikut: Pertama, untuk EYD ditemukan data yaitu:1) kesalahan penggunaan huruf, terdapat 82 kata yang salah dituliskan, 2) kesalahan penggunaan tanda baca 26, dan 3) kesalahan keefektivitas kalimat sebanyak 25.
PENERAPAN MODEL INKUIRI DALAM MENINGKATKAN KEMAMPUAN MENULIS TEKS LAPORAN SISWA SMP
Authors: Juliana Damanik Oktavia , Telaubanua Sadieli , Saleh Ramadhan
Published: October 2020

Penelitian ini bertujuan untuk meningkatkan kemampuan menulis teks laporan siswa kelas VIIC SMP Negeri 3 pancurbatu dengan menggunakan model pembelajaran inkuiri. Keberhasilan penelitian ini dilihat dari kriteria ini Penggunaan model pembelajaran inkuiri setelah diberi tindakan pada siklus I belum mampu meningkatkan kualitas pembelajaran menulis teks laporan pada siswa. Hal ini ditunjukkan dari jumlah skor rata-rata yang diperoleh siswa 63,8 dan KKK siswa yang tuntas 20% (5 siswa) dan yang tidak tuntas 80% (20 siswa). Penggunaan model pembelajaran inkuiri setelah diberi tindakan pada siklus II dapat meningkatkan hasil kemampuan menulis teks laporan siswa. Hal ini dapat terlihat pada perolehan jumlah skor rata-rata 83,4 dan KKK siswa yang tuntas 88% (22 siswa) dan yang tidak tuntas 12% ( 3 siswa). Berdasarkan hasil penelitian, disimpulkan bahwa penggunaan model pembelajaran inkuiri berhasil dan mampu meningkatkan kemampuan menulis teks laporan siswa kelas VII-C SMP Negri 3 Pancurbatu.
PENINGKATAN KETERAMPILAN MENULIS TEKS BERITA MELALUI PENGGUNAAN MEDIA VIDEO PADA SISWA SMP
Authors: Marlina S Heddi , T Sadieli , Saleh L Ramadhan
Published: October 2020

Penelitian ini bertujuan untuk meningkatkan keterampilan menulis teks berita melalui penggunaan media video pada siswa kelas VIII-A SMP Swasta Imelda Medan pada tahun pembelajaran 2018/2019. Dalam pembelajaran Bahasa Indonesia, menulis merupakan aspek keterampilan yang harus dikuasai selain aspek keterampilan menulis. Standar kompetensi menulis yang diharapkan dari siswa kelas VIII-A SMP Swasta Imelda Medan pada tahunpembelajaran 2018/2019 adalah mampu menulis kalimat-kalimat dan paragraf dengan baik, menulis karangan sederhana, tanda baca, kosa kata yang semuanya diarahkan untuk menumbuhkan kebiasaan menulis. Pendekatan yang digunakan dalam penelitian ini menggunakan metode Penelitian Tindakan Kelas melalui uji coba ide ke dalam situasi nyata yang diharapkan mampu memperbaiki dan meningkatkan kualitas proses belajar mengajar di skelas. Sehingga dapat disimpulkan bahwa berdasarkan rumusan masalah dan hipotesis tindakan, penggunaan media video dapat meningkatkan kemampuan menulis teks berita siswa kelas VIII-A SMP Swasta Imelda Medan dan hal tersebut dapat membantu guru bidang studi Bahasa Indonesia untuk lebih aktif lagi dalam mengelola kondisi kelas.
Pengaruh Penguasaan Kalimat Efektif Terhadap Kemampuan Menulis Karangan Narasi Pada Siswa
Authors: Apriani Hamidah , Rahman Fauzi , Hidayat Ryan
Published: October 2020

Penelitian bertujuan untuk mengetahui pengaruh penguasaan kalimat efektif terhadap kemampuan menulis karangan narasi siswa. Penelitian ini menggunakan metode survei dengan menggunakan teknis analisis korelasional. Sampel penelitian berjumlah 70 orang siswa yang dipilih secara random dari seluruh siswa kelas VII SMP. Teknik analisis statistik yang digunakan adalah statistika deksriptif untuk mencari rata-rata, median, modus, standar deviasi dan histogram, dan teknik statistika inferensial yaitu untuk mengetahui besaran skor hubungan dan sumbangan variabel bebas terhadap variabel terikat kemudian dilanjutkan dengan uji t untuk mengetahui signifikansi hubungan antarvariabel tersebut. Berdasarkan hasil penelitian, dapat disimpulkan bahwa: terdapat pengaruh yang signifikan penguasaan kalimat efektif terhadap kemampuan menulis karangan narasi, hal tersebut dibuktikan dengan sig. 0,045 < 0,05 dan thitung = 2,084, Artinya, penguasaan kalimat efektif terbukti memiliki pengaruh positif terhadap kemampuan menulis karangan narasi siswa.
Penggunan Sevima Edlink Sebagai Media Pembelajaran Online untuk Mengajar dan Belajar Bahasa Indonesia
Authors: Wibowo Andi , Rahmayanti Indah
Published: October 2020

Penelitian ini bertujuan untuk melihat dan menelaah dari penggunaan Sevima Edlink sebagai media pembelajaran online untuk mengajar dan belajar bahasa Indonesia. Hasil evaluasi untuk media Sevima Edlink ditelaah dengan menggunakan teori Sections dan Chaple, bahwa media Sevima Edlink ini sangat direkomendasikan untuk dijadikan sebuah media pembelajaran elektronik pada pembelajaran bahasa Indonesia, karena memiliki fitur-fitur yang mendukung pada kebutuhan-kebutuhan pembelajaran bahasa Indonesia. Media Sevima Edlink ini selain bisa memberikan materi, media tersebut juga bisa berinteraksi dengan jarak jauh melalui sebuah diskusi percakapan via tertulis maupun video. Media ini diharapkan terus dipromosikan di satuan pendidikan yang terendah hingga yang tertinggi agar akademisi maupun pelajar bisa mengetahui adanya keberadaan media Sevima Edlink ini. Saran dari peneliti adalah untuk fitur yang sudah ada sementara bisa ditingkatkan lagi agar pembelajaran jarak jauh semakin nyaman dan media ini lebih baik bisa digunakan digunakan dari tingkat satuan pendidikan yang terendah tanpa ada kategori media yang sering digunakan oleh perguruan tinggi.
Konflik Batin Psikologis Dalam Naskah Drama Badai Sepanjang Malam Karya Max Arifin
Authors: Suni Indra Aditya Arsyad
Published: October 2020

Karya sastra yang berjenis drama menjadi mimik untuk jendela kehidupan nyata. Dalam naskah drama Badai Sepanjang Malam karya Max Arifin tergambar bagaimana idealisme yang tinggi mampu dipatahkan oleh pahitnya kehidupan. Mental serta keteguhan hati nurani dipertaruhkan di atas sebuah idealisme. Penulis mengkaji salah satu naskah drama, yaitu naskah drama Badai Sepanjang Malam karya Max Arifin melalui pendekatan prakmatik dari sudut pandang psikologi. Karena dalam naskah drama Badai Sepanjang Malam karya Max Arifin terdapat konflik batin yang sangat rumit. Sumber data penelitian di dapat dari kutipan-kutipan dialog naskah drama Badai Sepanjang Malam karya Max Arifin. Metode yang digunakan penulis memakai metode penelitian deskriptif kualitatif. Dengan hal tersebut penulis berharap dapat memberikan kajian yang objektif.

 

Literary works that are of the type of drama become the expression for the window of real life. In the drama drama Badai Sepanjang Malam Max Arifin's work illustrates how high idealism can be broken by the bitterness of life. Mental and perseverance are at stake above an idealism. The author examines one of the drama scripts, namely the drama script Badai Sepanjang Malam by Max Arifin through a pragmatic approach from a psychological point of view. Because in the drama script Badai Sepanjang Malam Max Arifin's work contains a very complicated inner conflict. The source of research data can be obtained from dialogues from Max Arifin's drama drama dialogues by Badai Sepanjang Malam. The method used by the author uses descriptive qualitative research methods. With this the authors hope to provide an objective study.
Penyimpangan Psikologis Tokoh Cerita Kukila (Rahasia Pohon Rahasia) Karya M. Aan Mansyur
Authors: Kartika Rina , Setiadi David , Agustiani Tanti
Published: October 2020

Penyimpangan psikologis merupakan sebuah perilaku yang menyimpang dari perilaku yang biasa dilakukan oleh manusia. Penyimpangan tersebut bisa terjadi dikarenakan beberapa faktor yang terjadi dalam diri seseorang yang dipengaruhi oleh lingkungan yang ada di sekitar. Dalam novelet yang berjudul “Kukila (Rahasia pohon Rahasia)” karya M. Aan Mansur terdapat beberapa penyimpangan psikologis yang terjadi pada tokoh Kukila di dalamnya terdapat empat penyimpangan psikologis dan tujuh factor penyebab psikologis yang terjadi pada cerita tersebut. Metode penelitian yang digunakan deskriptif kualitatif, yaitu mendeskripsikan penyimpangan psikologis yang terjadi pada novelet yang berjudul: “Kukila (Rahasia pohon Rahasia)” karya M. Aan Mansur. Penelitian ini mempunyai tujuan yaitu untuk mengetahui penyimpangan tokoh perempuan yang bernama Kukila pada novelet yang berjudul “Kukila (Rahasia pohon Rahasia) karya M. Aan Mansur. Berdasarkan hasil penelitian ini ditemukan empat penyimpangan psikologis yaitu: depresi, oppressed, axienty, dan adultery serta enam faktor penyebab penyimpangan psikologis yaitu faktor rumah tangga,  psikologi, keluarga, agama, seksual, dan sosial.
Unsur Kumpulan Cerpen Menghardik Gerimis Karya Sapardi Djoko Damono Sebagai Bahan Pembelajaran
Authors: Hikmah Dede
Published: October 2020

Penelitian ini difokuskan pembahasannya pada korelasi makna. Tujuannya untuk mengetahui makna bahasa Indonesia yang baik dan benar dengan qaulan ma’rufa dan qaulan sadida. Jenis metode penelitian yang digunakan adalah kualitatif yang terfokus pada pendeskripsian hasil. Pada proses penelitiannya, keempat istilah tersebut merujuk pada teori-teori mengenai makna kata yang disesuaikan dalam kaidah bahasa, seperti yang termaktub dalam KBBI dan kitab-kitab tafsir Alquran. Bahasa Indonesia yang baik diartikan sebagai bahasa yang dipertuturkan sesuai dengan tempatnya. Bahasa Indonesia yang benar adalah bahasa Indonesia yang mengikuti kaidah kebahasan, yaitu PUEBI dan KBBI. Qaulan ma’rufa sebagai salah satu prinsip kesantunan berbahasa dalam perspektif Alquran mengandung makna pertuturan yang baik dan tidak menyakitkan hati seseorang. Qaulan sadida dimaknai sebagai pertuturan yang benar sesuai dengan Alquran atau hadis.
Konflik Dalam Novel Bidadari Bermata Bening Karya Habiburrahman El-Shirazy
Authors: Umami Sahrul , Rahman Fauzi , Hidayat Ryan
Published: October 2020

Konflik merupakan perselisihan atau pertentangan yang terjadi antartokoh dalam sebuah cerita. Selain itu, konflik dapat terbagi beberapa bagian yaitu konflik fisik, batin, dan sosial. Penelitian ini bertujuan mengetahui konflik dalam novel Bidadari Bermata Bening karya Habiburrahman El Shirazy. Penelitian ini menggunakan metode deskriptif kualitatif dengan teknik analisis isi, yaitu pendekatan yang dilakukan dengan cara menganalisis objek penelitian. Hasil penelitian ini menunjukkan bahwa: 1) konflik fisik yaitu meninggalnya Mbok Sani karena sungai meluap menghancurkan rumahnya dipinggiran sungai. 2) konflik batin yaitu Ayna yang terus menangis karena Pakde dan Budenya menolak lamaran Pak Kyai dan Bu Nyai, serta Gus Afif merasakan kesedihan terlambat melamar Ayna. 3) konflik sosial yaitu Ayna yang cekcok dengan Pakde dan Budenya karena menjodohkan Ayna dengan Yoyok anak saudagar kaya di kampungnya. Simpulan penelitian ini, konflik yang lebih muncul ialah konflik batin yang dialami oleh Ayna karena ia menikah dengan laki-laki yang bukan pilihannya. Namun, Ayna bercerai karena suami terjerat kasus korupsi dan menemukan laki-laki yang Ayna cintai yaitu Gus Afif.
Overview of Covid 19 and Unani formulation Tiryaq-e-Wabai
Authors: Khan Asim Ali , Afrin Zeba , Kumar Pradeep
Published: October 2020

Coronavirus disease 2019 (COVID-19) is arguably the biggest health crisis the world has faced in 21st century. It is an infectious disease and declared pandemic by the World Health Organization. It is a pandemic disease of modern time with unique and rapid transmission rate and affected almost all the nations without respecting any border. It’s a novel infection which is caused by SARS CoV-2 with Serious Clinical manifestation i.e. Fever, Cough, Cold, Respiratory distress further may result into Death. There is no definite therapeutic drug or vaccine available for COVID-19 so far despite numerous series of experimental and clinical research. Research is in progress on therapeutic efficacy of various agents including antimalarials (Chloroquine and Hydroxychloroquine), antiviral drugs, and convalescent serum of recovered patients. Unani system of medicine is one of the traditional systems of medicine which is being explored for providing preventive, supportive and rehabilitative care to patients. Unani system of medicine has a detailed description of drugs that are utilized in many infectious diseases, including respiratory infections. Immune response is essential to eliminate virus and to preclude disease progression to severe stages. Therefore, strategies to boost immune response are certainly important. Therefore, it is important to summarize the evidence regarding the preventive measures, control options such as immunostimulator and prophylactic treatment in Unani medicine against Covid- 19. This review summarizes various pharmacological actions of Unani formulation Tiryaq e wabai in unani literature and various reported pharmacological activities which can possibly provide prevention, control and reduction of complications of this deadly disease. 

Keywords: Unani medicine, Covid 19, immune response, Tiryaq e Wabai
Food constituents for inhibition of BabA of Helicobacter pylori
Authors: Al-Khafaji Zahra M. , Mahmood Aaisha B. , Mahmood Marium B.
Published: October 2020

Helicobacter pylori causes several gastric pathogeneses to human, nowadays the bacterium developed incredible drug and antibiotic resistance. The bacterium starts its activities by attachment to gastric epithelia via BabA as the main player in the\is process. The study was carried out to find/discover food constituents as inhibitors. Five molecules were obtained from the screening process, 2_3_4_5_6_Penta_O_acetyl_D_glucose, N2_N2_Dimethylguanosine, 5__Methylthioadenosine, Glyceryl_5_hydroxydecanoate, Monoisopropyl_citrate , in addition to two drugs Rivoglitazone and Tiapirinol not used for  Helicobacter pylori before. The molecules were docked with considerable binding affinities with different types of interactions. The molecules were checked for the safety of different aspects, they are of good synthetic accessibility and in agreement with the Lipinski rule of 5 which is essential for Helicobacter therapy.

Keywords: Helicobacter pylori, food constituents, BabA inhibition, SBDD
A Prospective Observational Study on Risk Factors and Prescribing Patterns of Drugs used in Stroke Patients at a Tertiary Care Teaching Hospital.
Authors: Hussainy Syed Areefulla , Habeeb Madiha , Jeelani Ayesha , Sultana Sumaiya , Meeran Mohammed Mohiuddin
Published: October 2020

Objectives: The main aim of the study is to identify the different risk factors, prescribing patterns of medication and rationality of the prescription by observing the management of stroke patients carefully.

Methodology: A prospective and observational study was carried out for a period of 6 months in an in-patient department of a tertiary care hospital. Patients above 18 years of age, patients of either sex and patients who previously had stroke were included. Children below 18 years, pregnant women, AIDS patients, patients unable to respond to verbal questions with no caretakers and patients with head injury were excluded.

Results: A total of 100 prescriptions were analyzed during the 6 months study period. This was found to be higher in males (79) and females (21). The higher risk with notable occurrence in the age group of 60-79 years (43%). Out of these study populations, (68%) experienced Ischemic stroke and (32%) experienced Hemorrhagic stroke. The major risk factors were Hypertension (62%), alcoholics (41%). Smoking (33%) and Diabetes (24%). Among the 100 prescriptions, Atorvastatin was highly prescribed (96) followed by Pantoprazole (92), Mannitol (64). Out of 100 prescriptions, (67) were rational and (33%) were irrational.

Conclusion: The prescribing patterns of drug should be based on specificity and severity of stroke in order to facilitate rational use of drugs providing optimal care. Early management of hypertension and diabetes may reduce risk of stroke. Cessation of smoking and alcohol place a key role in prevention of stroke.

Keywords: Ischemic stroke, hemorrhagic stroke, hypertension, diabetes.
Evaluation of the curative role, Anti-inflammatory and anti-oxidative activity of some dietary spices on carrageenan induced paw edema in albino Wistar rats
Authors: Bouaoud Khaoula , Menadi Noreddine , Zairi Mohammed , Bouazza Sofiane , Bekhadda Hadjer , Meraou Asmaa , Benali Amina , Bensaid Ilies , MAI Hicham , Benali Mahmoud , Demmouche Abbassia
Published: October 2020

Background: Inflammation is a major burning problem worldwide and billions of individuals are affected. Some of the spices used daily in Algerian cuisine have been known to possess major anti-inflammatory effects. Turmeric, red pepper, ginger, cinnamon and cumin  etc. are a few of the wide spectrum of spices used in Algeria.

The aim of the study was to investigate the antiinflammatory effect  and anti actvity of some dietary spices in carrageenan induced models of inflammation on Wistar  rats.

Methods: Albino wistar rats were divided into four groups. Inflammation was induced on the animal by injecting the right hand paw with carrageenan (0.1 ml of 1%). Group 1  was fed with food and water and  treated with carrageenan (control) whereas group 2 and  3 treated with different doses (100 and 200 mg/kg/bw) of aqueous extract of some dietary spices with carrageenan, respectively. Group 4  treated with standard drug diclofenac sodium (10 mg/kg b.w., reference drug for inflammation), once for 24 hrs.

Results: The content of total phenolic was 137.2±21.6 mg/g and flavonoids 122.3±5.8 mg/g. After 60, 120, 180, 240 and 300 min, the data indicate that  some dietary spices 100 and 200 mg/kg was significantly effective reducing paw edema volumes induced by carrageenan compared to control (p <0.01). The levels of serum pro-inflammatory white blood cells, neutrophile, lymphocyte, monocyte,  eosinophile, total protein and protein c reactive and total cephalin KADIN  and platelts in the control group were significantly increased by carrageenan injection compared with the normal group. The rats pretreated with some spices 100 and 200 mg/kg had significantly lower levels of pro-inflammatory to compare control group. The paw edema in carrageenan-induced rats was considerably reduced by treating with 100 and 200  mg/kg aqueous extract of some dietary spices when compared to the untreated  rats (p<0.001).

Conclusion : The present results clearly demonstarted that carrageenan significantly increased paw edema whereas some dietary treated rats significantly decreased the paw edema. The study underlines the importance of some of the frequently used spices (Turmeric, red pepper, ginger, cinnamon and cumin)  in the treatment of inflammation.