bluuebunny/crossref_metadata_2025 huggingface dataset:
CNDP1 Suppresses the Malignant Behavior of Hepatoma Cell via Restricting PI3K-AKT-mTOR Activation
Authors: Du Youwen , Pan Linxin , Zhang Wenchen , Wei Shuangbiao , Fan Xu , Zhang Na , Wei Pengjun , Chen Xiaoqian , Qiao Zhi , Xie Li
Published: September 2024

Introduction:

Hepatocellular carcinoma (HCC) is a global health problem with increasing morbidity and mortality, and exploring the diagnosis and treatment of HCC at the gene level has be-come a research hotspot in recent years. As the rate-limiting enzyme of carnosine hydrolysis, CNDP1 participates in the progress of many diseases, but its function in HCC has not been fully elucidated.

Methods:

This study firstly screened differentially expressed genes from the biochip related to HCC by bioinformatic analysis, and CNDP1 was finally selected for in-depth study. Then the bioinformatics analysis results were validated by detecting the expression of CNDP1 in human HCC samples and he-patoma cell lines. Furthermore, the effect of CNDP1 on the malignant behavior of hepatoma cell lines were assessed using MTT colorimetric assay, EdU staining assay, colony formation, wound-healing assay and transwell, and the molecular mechanism was also preliminarily explored.

Results:

This study found that CNDP1 expression was decreased significantly in human HCC tissues and cell lines, and its overexpression could significantly suppress cell proliferation, migration and in-vasion of hepatoma cell lines. Mechanistically the GeneMANIA database predicted that CNDP1 could interact with various proteins involved in regulating PI3K-AKT-mTOR signaling pathway. Further-more, this study showed that CNDP1 overexpression could effectively inhibit the activation of PI3K-AKT-mTOR signaling pathways, more significantly, inhibition of PI3K-AKT-mTOR signaling path-way could disrupt the anti-cancer effect of CNDP1 on HCC.

Conclusion:

This study confirm that CNDP1 expression is decreased significantly in HCC, and has potential anti-cancer activity, this discovery provides a cytological basis for further understanding the biological function of CNDP1 and diagnosis and gene therapy of HCC in the future.
Efficacy of Adjunctive Local Antimicrobials to Non-Surgical Periodontal Therapy in Pocket Reduction and Glycemic Control of Patients with Type 2 Diabetes: A Network Meta-Analysis
Authors: de Oliveira Domitilla Marchiori Sant’Anna Leal , de Souza Ana Luiza Magalhães , da Rocha Nogueira Filho Getulio , Martins-Pfeifer Carolina Castro , Stefani Cristine Miron
Published: September 2024

Objective:

This network meta-analysis [NMA] investigated the efficacy of adjunctive
use of subgingivally delivered antimicrobials to non-surgical periodontal therapy [NSPT] in the
glycemic control and periodontal pocket depth (PPD) reduction in patients with type 2 diabetes
(T2D).

Methods:

Seven databases, grey literature, and registry platforms were searched up to February
2024 to identify randomized clinical trials (RCT) fulfilling the eligibility criteria. The risk of bias
was assessed through Cochrane’s tool (RoB 2). Two frequentist NMA were performed using a
random-effects model to calculate mean differences (MD) as an effect measure and to
quantitatively evaluate the glycated hemoglobin (HbA1c) and PPD. The certainty of evidence
was assessed through the GRADE approach in a partially contextualized framework for
interpreting results. Ten RCTs were included.

Results:

In total, 261 patients were treated with eight different local antimicrobials adjuvants to
NSPT (azithromycin gel, clarithromycin gel, tetracycline fiber or ointment, chlorhexidine gel,
doxycycline nanospheres, minocycline gel, and satranidazole gel), while 249 patients received
NSPT alone or associated to placebo. Considering PPD reduction (8 included studies), the best
results were found after six months for satranidazole gel (MD -2.64mm; 95%CI -3.56, -1.72;
moderate evidence certainty). For HbA1c control (7 included studies), doxycycline gel (MD -
0.80%; 95%CI -1.70, 0.10), chlorhexidine gel (MD -0.68%; 95%CI -1.34, -0.02), and
tetracycline fiber (MD -0.62%; 95%CI -0.85, -0.39) showed promising results after three months
(low evidence certainty).

Conclusion:

The adjunctive use of satranidazole gel probably reduces PPD after a 6-month
follow-up, while doxycycline gel, chlorhexidine gel, and tetracycline fiber may decrease HbA1c
values in patients with T2D and periodontitis treated with NSPT after a 3-month follow up.
Investigating, Characterizing, and Optimizing Various Modified Surfaces of Titanium Dental Implants using Anodization and Physical Patterns
Authors: Garshasbi Hamid Reza , Askari Esfandyar , Kashani Ghazal Kadkhodaie , Naghib Seyed Morteza , Tilebon Seyyed Mohamad Sadati , Emamian Seyed Amirhossein , Ramezanpour Hosseinali , Eslami Hossein , Ansari Mojtaba , Salehi Malihe
Published: September 2024

Background:

Implants made of titanium are significant in the orthopedic and dental
fields. Strong osteointegration can only be achieved by surface modification technologies. The benefits
of titanium are numerous, but its inert state prevents it from integrating with human cell's biologically.
The titanium implant’s surface is crucial for osseointegration and implant success; hence this
is necessary. How to apply osteoconductive coatings or increase the surface roughness of titanium
dental implants has been investigated. Surface treatments include grit blasting, acid etching, anodizing,
and coatings with calcium phosphate. Clinical efficacy has been demonstrated for most marketed
surfaces (>95%). The exact involvement of surface topography and chemical reactions in early
dental implant osseointegration is still unclear.

Methods:

Sixteen implant samples were made with different parameters. Each one has 5 parameters,
including Sandblast Pressure (SP), Sandblast Cycle (SC), Anodizing Time (AT), Anodizing Voltage
(AV), and Etching Time (ET). Physical and chemical characterization was used to identify optimized
samples. SEM, EDS, XRD, Biodegradation, Contact Angle, Microhardness, MTT, Real-Time PCR,
and Antibacterial tests were taken from the samples.

Results:

Different surface treatments showed that all surfaces were roughened and micro-nano structures
had been shaped. The microhardness of some samples increased during surface treatment.
Sample number 14 has potentially antibacterial activities.

Conclusion:

Future dental implants may be able to detect tissue formation and cellular attachment,
which could facilitate medication release. The future of flexible, multipurpose dental implants lies in
additive manufacturing, biosensing, and triggered drug-release technologies.
A Simple and Novel Technique for the Determination of Rhodamine B in Cosmetics Based on Dispersive Surfactant Micelle-mediated Extraction
and Image Colorimetric Analysis
Authors: Khoshmaram Leila , H. Fatemeh Zakeran
Published: September 2024

Aims:

The primary objective of this study was to develop a simple, selective, sensitive,
and rapid method for the determination of trace levels of Rhodamine B in different cosmetic items.

Background:

At present, synthetic dyes in various colors are essential in cosmetic products, not only
for adding pleasant scents, but also for enhancing their appeal and restoring natural colors. Rhodamine
B, a pink synthetic azo dye, is widely used in the cosmetic industry. It poses risks if ingested by
humans and animals, causing skin, eye, and respiratory irritation. Scientific studies have shown that
it has carcinogenic, reproductive, developmental, neurotoxic, and chronic toxic effects on both humans
and animals. Therefore, the improvement of precise and fast measurement techniques for detecting
Rhodamine B in different sample types is crucial.

Objective:

The objective of this study was to find a fast, accurate, and sensitive method for the determination
of trace levels of Rhodamine B in different cosmetic items.

Methods:

The technique used has been based on Dispersive Surfactant Micelle-mediated Extraction
(DSME) combined with digital image analysis.

Results:

The optimized method yielded a linear calibration graph ranging from 25 to 300 μg L-1,
with a correlation coefficient of 0.9975 and the Limit of Detection (LOD) of 6.7 μg L-1. The proposed
method was used to measure Rhodamine B in lipstick and nail polish samples, resulting in
satisfactory recoveries ranging from 97.8 to 107.2%.

Conclusion:

DSME could remove the necessity of high temperature, hazardous organic solvents, and
anionic surfactants in Cloud Point Extraction (CPE) and Catanionic Surfactants-based Coacervation
Extraction (CSCE). Additionally, experiments have shown the results from digital image analysis to
be in line with those from a commercial UV-Vis spectrophotometer and a spectrofluorometer. The
authors believe that utilizing DSME image analysis could be a beneficial alternative to the analytical
analysis of other colored species in routine analysis.
Immunomodulatory Roles of IL-15 in Immune Cells and its Potential for Cancer Immunotherapy
Authors: Liu Youhan , Ma Wen , Tian Xuewen , Wang Qinglu , Lu Xin , Luo Ying , Xu Jun
Published: September 2024

:

Interleukin-15 (IL-15) was identified in 1994 as a T-cell growth factor with the capability to mimic the
functions of IL-2. IL-15 engages with the IL-15Rα subunit expressed on the surface of antigen-presenting cells
(APCs) and, through a trans-presentation mechanism, activates the IL-2/IL-15Rβγ complex receptor on the surface
of natural killer (NK) cells and CD8+ T cells. This interaction initiates a cascade of downstream signaling
pathways, playing a pivotal role in the activation, proliferation, and anti-apoptotic processes in NK cells, CD8+ T
cells, and B cells. It provides a substantial theoretical foundation and potential therapeutic targets for tumor immunotherapy.
Whether through active or passive immunotherapeutic strategies, IL-15 has emerged as a critical
molecule for stimulating anti-tumor cell proliferation.
Lok Purusha Siddhant - The master of all Siddhanta
Authors: Vijay Kumar  , Vijay Shankar Pandey
Published: September 2024

Loka Purusha Samya Siddhanta is as one of the unique principles of Ayurveda, on the basis of which the functioning of human beings, diseases and their management is understood. The fundamental concept of this theory is that the living being is the miniature reflection of the universe. Whatever is there in this universe is also present in a human being. According to Yajurveda: All that exist in Brahmanda (universe) also exist in Pinda (individual). It is a master as all Siddhanta explained in Ayurveda texts follows Lok Purusha Siddhant. This principle is also very useful from the point of view of achieving the purpose of Ayurveda. If there is a changes occurring in the universe, it causes structural and functional changes in the body. By knowing the changes in Loka, we can rusticate or minimize the upcoming deformities in the body following related Aahar Vihar as directed in Ritucharya too. In modern treatment, Proteins, Minerals, supplements, Vitamins etc. are prescribed which is according to this Siddhanta.
An etiopathological study of Mootra-Ashmari with special reference to Urolithiasis: A Literary Review
Authors: Sonam Kumari Keshari  , Avadhesh Kumar  , Neelam Gupta  , Deena Nath Singh  , Jai Shankar Prasad
Published: September 2024

Mootra-Ashmari is a disease of urinary tract which causes problems in many ways including passage of urine. The waste material when not dissolve completely in urine and obstruct urinary path then Mootra-Ashmari may occur which is termed as renal calculi/urolithiasis/nephrolithiasis in modern medical sciences. As per Sushruta Samhita, Ashmari is included in Ashtamahagada due to its fatal nature. Description of Ashmari is found in almost all Samhitas of Ayurveda for e.g. either as a type of Mootraghata (Acharya Charaka) or as a separate disease (Acharya Sushruta). Ashmari is one of the most common disorders of Mootravaha Srotasa. It is Kaphapradhana Tridoshaja Vyadhi. Pathya-Apathya is an important factor in Mootra-Ashmari. Urinary stones frequently occur worldwide. Prevalence rate of 1-5% are reported in Asia, 12% in India. it is very much important to prevent occurrence of the disease because of the dreadful complications caused by Mootra-Ashmari and its high chances of recurrence.
Management of type-2 Diabetes Mellitus - A Case Report
Authors: Pankaj Singh Kushwaha  , Pooja Lekhak  , R.K. Joshi  , Harish Bhakuni  , Neha Agrawal
Published: September 2024

Type 2 Diabetes Mellitus (T2DM) is a prevalent metabolic disorder characterized by elevated blood glucose levels. Ayurveda identifies a similar condition known as Madhumeha, a type of Prameha associated with an imbalance in Kapha and Vata Doshas. This study explores the efficacy of Ayurvedic treatment in managing T2DM. Methods: A 50-year-old male patient with T2DM and no significant history of major illness was treated using a holistic Ayurveda approach. The treatment regimen included Ayurvedic formulations such as Madhumehari Churna, Ojaswani Churna, Chandraprabha Vati, and Phaltrikadi Kwath and Basti procedure. Dietary and lifestyle modifications were also recommended, focusing on low glycemic foods and regular physical activity. The patient was monitored over three months, with assessments of fasting blood sugar (FBS), postprandial blood sugar (PPBS), and HbA1c levels before and after the treatment period. Results: Post-treatment, the patient showed a significant reduction in blood sugar levels and improvement in diabetes-related symptoms. FBS decreased from 150 mg/dl to 126 mg/dl, PPBS from 217 mg/dl to 158 mg/dl, and HbA1c from 9.2% to 6.9%. These results indicate the effectiveness of the Ayurvedic regimen in managing T2DM. Conclusion: The study demonstrates that Ayurvedic management, through a combination of Ayurvedic formulations, dietary interventions, and lifestyle modifications, can effectively control blood sugar levels and improve the quality of life for patients with T2DM.
Ayurvedic management for Parkinson's Disease : A comprehensive case report on Kampavata
Authors: Pankaj Sharma  , V. Balendu Krishnan  , Hari G.
Published: September 2024

Parkinson’s Disease (PD) is a progressive neurodegenerative disorder characterized by symptoms such as bradykinesia, tremors, impaired posture, balance, and muscle rigidity. This case report discusses a 57-year-old male with a decade-long history of PD, presenting with tremors, slurred speech, and neck rigidity, who sought Ayurvedic treatment after finding no relief from conventional biomedical approaches. The patient was assessed using Ayurvedic principles of Rogi-Roga Pareeksha as Kampavata, and accordingly, the treatment plan combining Rookshana (drying) and Snehana (oleation) therapies were adopted. The intervention included external therapies like Udvartanam (powder massage), Sarvanga Abhyanga (full body oil massage), Swedana (fomentation), and Vaitarana Basti (medicated enema). Internal medications included Maharasnayogaraja Guggulu Kashayam, Saraswatarishtam, Ashtavarga Kashayam and Brihatvatachintamani Rasa. Over a two-week treatment period, significant improvements were observed in tremors, bradykinesia, rigidity, gait, and speech, with the patient reporting enhanced quality of life and reduced stress. This case highlights the potential efficacy of Ayurvedic treatment modalities in managing neurodegenerative disorders like PD, particularly when conventional treatments fail to provide relief.
In Vitro Anti-Dandruff Activity of Karnasphotha (Cardiospermum helicacabum Linn.) against Malassezia furfur
Authors: Sarojini D Byadigi  , Ashwini Kochari
Published: September 2024

Background: Dandruff is a common skin condition that mainly affects the scalp. Almost half of the population at the pre-pubertal age and of any gender and ethnicity will be affected. It was discovered that the responsible agent is a scalp specific fungus, Malassezia globosa.  Karnasphotha (Cardiospermum helicacabum Linn.) commonly known as Balloon vine from Sapindaceae family is traditionally used for dandruff.  So here an attempt is made to study the in vitro efficacy of Karnasphota (Cardiospermum helicacabum Linn.) decoction against dandruff. Aims and Objectives: In vitro Antidandruff activity of Karnasphota Mula and Beeja by Agar cup method and Biocidal activity. Methodology: In vitro Antidandruff activity of Karnasphota (Cardiospermum helicacabum Linn.) Bija and Mula Kwatha against dandruff by – Agar cup method and Biocidal activity. Result: The Karnasphotha Moola showed good antidandruff activity against Malassezia furfur in different concentrations. Whereas Karnasphotha Beeja showed no antidandruff activity against Malassezia furfur in any concentrations. Conclusion: The Karnasphotha Moola is having significant Antidandruff properties.
DETERMINAN YANG MEMPENGARUHI KEMISKINAN DI JAWA TIMUR TA 2022 (PENDEKATAN PENDAPATAN DAERAH)
Authors: Musyaffa Muhammad Ashari , Agus Suman
Published: September 2024

As a Province with the highest number of poor-population, East Java was also recognized as a top province in poverty alleviation in 2021 and 2022, Although there are still differences in the levels of poverty among various districts and cities. However, East Java was also ranked as the third province with the highest regional income and holds significant authority in optimizing its local resources, evident from the role of Regional Original Revenue (PAD) in total regional income. Examining regional income, there is no research involving Other Legitimate Revenue as one of the components in poverty alleviation. Therefore, this study aims to explore the role of regional income in poverty alleviation, specifically considering the optimization of fiscal decentralization authority and regional income. Additionally, the research investigates the role of relative poverty in addressing disparities in poverty levels. Utilizing a quantitative research approach with the One Least Square Data Cross Section method, the study indicates that Regional Original Revenue, Transfer Funds, and Overall Regional Income are determinants influencing poverty, while Other Legitimate Revenue does not play a significant role. The conditions of poverty disparity and its alleviation can be addressed through a focus on the quality of education and health as aspects of relative poverty.
ANALISIS PENGARUH LUAS LAHAN, BESARNYA MODAL, TINGKAT PENDIDIKAN, DAN JUMLAH TENAGA KERJA TERHADAP PENDAPATAN USAHA TANI KOPI KECAMATAN DAMPIT
Authors: Arista Amanda Putri  , Bahtiar Fitanto
Published: September 2024

This study aims to find out how the variables of land area, amount of capital, level of education and number of labor affect the income of coffee farmers in Dampit District. In this study using descriptive quantitative research methods with classic assumptions test and multiple linear regression analysis . The data used in this study are primary data from questionnaires and interviews with 86 respondents. This study found that the variables of land area, amount of capital and level of education partially had an influence on the income of coffee farmers in Dampit. Meanwhile, the variable number of labor has no effect on the income of coffee farmers in Dampit. From the results of this study,  suggested for coffee farmers in Dampit District to further increase productivity both from physical capital or human resources in order to achieve results in the form of income  effectively and efficiently.
ANALISIS PENGARUH PENDAPATAN, HARGA, PREFERENSI, DAN GAYA HIDUP TERHADAP PERILAKU KONSUMSI MAKANAN JEPANG (STUDI PADA MAHASISWA FEB UB)
Authors: Ramadhan Muh. Rizki , Fadjar Nurman Setiawan
Published: September 2024

Today, students' consumption is not only limited to college-related needs but also extends to the desire for certain types of food, including Japanese cuisine. Japanese food has become one of the most popular international cuisines in Indonesia, as evident from the increasing number of Japanese food outlets across various cities in the country. The aim of this study was to determine the impact of income, price, preferences, and lifestyle on Japanese food consumption behavior among students of the Faculty of Economics and Business at Brawijaya University. Data collection techniques in this study involved distributing questionnaires to 100 students. Based on the results of binary logistic regression analysis, it shows that partially, income, price, and lifestyle have a positive and significant effect on Japanese food consumption behavior. Meanwhile, preference has no significant effect on Japanese food consumption behavior.
Effect of the Addition of Protected Soybean Groats on the Digestibility of Complete Feed for Thin-tailed Sheep
Authors: Riyanto Joko , Ikhsan Muh , Delji Roby , Nissa Nasta ‘Ainun
Published: September 2024

This study aims to investigate the effects of the use of complete feed containing different protected soybean groats on the digestibility of dry matter (DM), organic matter (OM), crude protein (CP), and total digestible nutrient (TDN) contents in male thin-tailed sheep. The materials used in this study were 15 male, thin-tailed sheep with an average initial body weight of 23.43 ± 1.40 kg. The research design used was a completely randomized design (CRD) with 3 treatments and 5 replicates. The treatments in this study were as follows: T1 = 100% complete feed, T2 = 90% complete feed + 10% protected soybean groats, and T3 = 80% complete feed + 20% protected soybean groats. The data were analysed via analysis of variance. The results of the analysis of variance revealed that the use of complete feed containing protected soybean groats had no significant effect (P > 0.05) on the consumption of dry matter, organic matter, or crude protein or on the digestibility of dry matter, organic matter, or crude protein. In conclusion, the use of complete feed containing protected soybean groats has no effect on the digestibility of dry matter (DM), organic matter (OM), crude protein (CP), or total digestibility of nutrients (TDN) in thin-tailed sheep.
Revisitando as relações entre a Política Criminal, a Dogmática (Penal) e a Criminologia: breves notas
Authors: Leite André Lamas
Published: September 2024

As relações entre a Política Criminal, a Criminologia e a Dogmática foram sendo modificadas desde a “enciclopédia das ciências criminais” até à ciência conjunta do Direito Penal. O específico modo de relacionamento entre elas é analisado à luz dos modelos de Estado de Direito historicamente surgidos, para depois se explanar uma visão hoje maioritária e que, em vários aspectos, é disputada pelo autor.
PENGEMBANGAN MEDIA PEMBELAJARAN KOMIK DIGITAL MATERI PENGOLAHAN SUP DAN SOTO INDONESIA UNTUK SISWA SMK KULINER
Authors: Syahidah Syifa Mutiah , Ratnaningsih Nani
Published: September 2024

Penelitian ini memiliki tujuan yaitu mengembangkan media pembelajaran berupa media komik digital padamateri Pengolahan Sup dan Soto Indonesia untuk siswa SMK Kuliner kelas XI dan mennguji kelayakannya.Penelitian ini menggunakan jenis penelitian dan pengembangan Research and Development (R&D) dengan model4D yaitu Define, Design, Develop dan Disseminate yang dilaksanakan di SMKN 4 Yogyakarta. Pengumpulan datadalam penelitian ini dilakukan dengan observasi, wawancara dan pengisian angket. Analisis data dilakukan denganstatistik deskriptif. Hasil media komik digital yang dikembangkan meliputi ukuran komik A5 (21cmx14,8cm),dengan jumlah total 29 halaman yang terdiri daru 1 halaman cover, 2 halaman intro, 24 halaman isi, 1 halamankarakter dan 1 halaman penutup, pada materi pengolahan dan penyajian sup dan soto Indonesia yang terdiri daripengertian, klasifikasi, karakteristik, komposisi, kriteria hasil, teknik pengolahan, teknik penyajian.. Hasilkelayakan media yaitu komik digital dinyatakan layak oleh validator media dan validator materi dan hasil uji cobapada siswa kelas XI kuliner 5 SMK N 4 Yogyakarta mendapatkan hasil 88% menyatakan sangat layak dan 12%menyatakan layak.
MANAJEMEN PENYELENGGARAAN MAKANAN DI IHSANUL FIKRI BOARDING SCHOOL MUNGKID MAGELANG
Authors: Azimah Difa Husnul , Mulyatiningsih Endang
Published: September 2024

Tujuan penelitian ini adalah untuk: mengetahui manajemen penyelenggaraan makan di Ihsanul Fikri Boarding SchoolMagelang, meliputi perencanaan menu dan anggaran belanja, pengadaan, penerimaan dan penyimpanan bahan makan,persiapan dan pengolahan bahan makan, pendistribusian makanan dan sanitasi higiene makanan di Ihsanul Fikri BoardingSchool Mungkid Magelang.Penelitian ini merupakan penelitian deskriptif. Subjek penelitian ini adalah kepala dapur, juru masak, guru, dansantri Ihsanul Fikri Boarding School Mungkid Magelang sebanyak 12 orang. Metode pengumpulan data menggunakanobservasi, wawancara dan dokumentasi sebanyak 34 indikator. Pengolahan data menggunakan reduksi data, penyajian datadan penarikan kesimpulan dilakukan dengan triangulasi.Hasil penelitian menunjukkan bahwa: (1) Perencanaan menu di IFBS Magelang belum disesuaikan dengan kebutuhangizi setiap santri dan masih terdapat menu yang tidak variatif. (2) Perencanaan anggaran belanja terdapat ketidaksesuaianantara anggaran yang ditentukan dengan pengeluaran belanja. (3) Pengadaan bahan makanan di IFBS Magelang dilakukandengan cara pengadaan bahan makanan kering dan basah dan diadakan setiap hari. (4) Penerimaan bahan makanan olehpetugas dapur yang diawasi kepala dapur namun pengecekan spesifikasi bahan tidak dilakukan. (5) Penyimpanan bahanmakanan dilakukan oleh juru masak pada saat bahan makanan diantarkan tidak ada penanggung jawab khusus sehinggabahan tidak tertata dengan baik. (6) ersiapan bahan makanan dilakukan secara tim meliputi semua bahan makanan, bumbu,dan peralatan masak namun kadangkala tidak disesuaikan dengan panduan resep. (7) Pengolahan kurang terlaksana denganbaik karena tidak sesuai dengan cara pemasakan bahan yang tepat. (8) Pendistribusian dan penyajian menggunakan metodedesentralisasi yang memungkinkan santri tidak mengambil makanan sesuai porsi yang dibutuhkan. (9) Higiene penjamahmakanan terlaksana dengan sangat baik perihal kebersihannya, namun terdapat kekurangan dalam menggunakan alat bantumasak. (10) Sanitasi sarana dan lingkungan produksi sudah sesuai standar penyelenggaraan makan institusi. Disarankankepada pihak yayasan lebih memperhatikan kelengkapan peralatan dan bahan di dapur, serta higiene sanitasi sehinggamanajemen penyelenggaraan makanan berjalan dengan optimal.
User Views on Online Sexual Health Symptom Checker Tool: Qualitative Research
Authors: King Alicia Jean , Bilardi Jade Elissa , Towns Janet Mary , Maddaford Kate , Fairley Christopher Kincaid , Chow Eric P F , Phillips Tiffany Renee
Published: September 2024

Background

Delayed diagnosis and treatment of sexually transmitted infections (STIs) contributes to poorer health outcomes and onward transmission to sexual partners. Access to best-practice sexual health care may be limited by barriers such as cost, distance to care providers, sexual stigma, and trust in health care providers. Online assessments of risk offer a novel means of supporting access to evidence-based sexual health information, testing, and treatment by providing more individualized sexual health information based on user inputs.

Objective

This developmental evaluation aims to find potential users’ views and experiences in relation to an online assessment of risk, called iSpySTI (Melbourne Sexual Health Center), including the likely impacts of use.

Methods

Individuals presenting with urogenital symptoms to a specialist sexual health clinic were given the opportunity to trial a web-based, Bayesian-powered tool that provides a list of 2 to 4 potential causes of their symptoms based on inputs of known STI risk factors and symptoms. Those who tried the tool were invited to participate in a once-off, semistructured research interview. Descriptive, action, and emotion coding informed the comparative analysis of individual cases.

Results

Findings from interviews with 14 people who had used the iSpySTI tool support the superiority of the online assessment of STI risk compared to existing sources of sexual health information (eg, internet search engines) in providing trusted and probabilistic information to users. Additionally, potential users reported benefits to their emotional well-being in the intervening period between noticing symptoms and being able to access care. Differences in current and imagined urgency of health care seeking and emotional impacts were found based on clinical diagnosis (eg, non-STI, curable and incurable but treatable STIs) and whether participants were born in Australia or elsewhere.

Conclusions

Online assessments of risk provide users experiencing urogenital symptoms with more individualized and evidence-based health information that can improve their health care–seeking and provide reassurance in the period before they can access care.
Constructing a Hospital Department Development–Level Assessment Model: Machine Learning and Expert Consultation Approach in Complex Hospital Data Environments
Authors: Liu Jingkun , Tai Jiaojiao , Han Junying , Zhang Meng , Li Yang , Yang Hongjuan , Yan Ziqiang
Published: September 2024

Background

Every hospital manager aims to build harmonious, mutually beneficial, and steady-state departments. Therefore, it is important to explore a hospital department development assessment model based on objective hospital data.

Objective

This study aims to use a novel machine learning algorithm to identify key evaluation indexes for hospital departments, offering insights for strategic planning and resource allocation in hospital management.

Methods

Data related to the development of a hospital department over the past 3 years were extracted from various hospital information systems. The resulting data set was mined using neural machine algorithms to assess the possible role of hospital departments in the development of a hospital. A questionnaire was used to consult senior experts familiar with the hospital to assess the actual work in each hospital department and the impact of each department’s development on overall hospital discipline. We used the results from this questionnaire to verify the accuracy of the departmental risk scores calculated by the machine learning algorithm.

Results

Deep machine learning was performed and modeled on the hospital system training data set. The model successfully leveraged the hospital’s training data set to learn, predict, and evaluate the working and development of hospital departments. A comparison of the questionnaire results with the risk ranking set from the departments machine learning algorithm using the cosine similarity algorithm and Pearson correlation analysis showed a good match. This indicates that the department development assessment model and risk score based on the objective data of hospital systems are relatively accurate and objective.

Conclusions

This study demonstrated that our machine learning algorithm provides an accurate and objective assessment model for hospital department development. The strong alignment of the model's risk assessments with expert opinions, validated through statistical analysis, highlights its reliability and potential to guide strategic hospital management decisions.
Best Practices for Designing and Testing Behavioral and Health Communication Interventions for Delivery in Private Facebook Groups: Tutorial
Authors: Pagoto Sherry , Lueders Natalie , Palmer Lindsay , Idiong Christie , Bannor Richard , Xu Ran , Ingels Spencer
Published: September 2024

Facebook, the most popular social media platform in the United States, is used by 239 million US adults, which represents 71% of the population. Not only do most US adults use Facebook but they also spend an average of 40 minutes per day on the platform. Due to Facebook’s reach and ease of use, it is increasingly being used as a modality for delivering behavioral and health communication interventions. Typically, a Facebook-delivered intervention involves creating a private group to deliver intervention content for participants to engage with asynchronously. In many interventions, a counselor is present to facilitate discussions and provide feedback and support. Studies of Facebook-delivered interventions have been conducted on a variety of topics, and they vary widely in terms of the intervention content used in the group, use of human counselors, group size, engagement, and other characteristics. In addition, results vary widely and may depend on how well the intervention was executed and the degree to which it elicited engagement among participants. Best practices for designing and delivering behavioral intervention content for asynchronous delivery in Facebook groups are lacking, as are best practices for engaging participants via this modality. In this tutorial, we propose best practices for the use of private Facebook groups for delivery and testing the efficacy of behavioral or health communication interventions, including converting traditional intervention content into Facebook posts; creating protocols for onboarding, counseling, engagement, and data management; designing and branding intervention content; and using engagement data to optimize engagement and outcomes.
Best Practices for Designing and Testing Behavioral and Health Communication Interventions for Delivery in Private Facebook Groups: Tutorial (Preprint)
Authors: Pagoto Sherry , Lueders Natalie , Palmer Lindsay , Idiong Christie , Bannor Richard , Xu Ran , Ingels Spencer
Published: September 2024

UNSTRUCTURED

Facebook, the most popular social media platform in the United States, is used by 239 million US adults, which represents 71% of the population. Not only do most US adults use Facebook but they also spend an average of 40 minutes per day on the platform. Due to Facebook’s reach and ease of use, it is increasingly being used as a modality for delivering behavioral and health communication interventions. Typically, a Facebook-delivered intervention involves creating a private group to deliver intervention content for participants to engage with asynchronously. In many interventions, a counselor is present to facilitate discussions and provide feedback and support. Studies of Facebook-delivered interventions have been conducted on a variety of topics, and they vary widely in terms of the intervention content used in the group, use of human counselors, group size, engagement, and other characteristics. In addition, results vary widely and may depend on how well the intervention was executed and the degree to which it elicited engagement among participants. Best practices for designing and delivering behavioral intervention content for asynchronous delivery in Facebook groups are lacking, as are best practices for engaging participants via this modality. In this tutorial, we propose best practices for the use of private Facebook groups for delivery and testing the efficacy of behavioral or health communication interventions, including converting traditional intervention content into Facebook posts; creating protocols for onboarding, counseling, engagement, and data management; designing and branding intervention content; and using engagement data to optimize engagement and outcomes.
Достижения и перспективы фотоэлектроники на XXVII Международной конференции в НПО «Орион»
Authors: Наумов А.В.
Published: September 2024

29–31 мая 2024 года в Москве состоялась XXVII Международная научно-техническая
конференция по фотоэлектронике и приборам ночного видения. Конференция была
организована Государственным научным центром Российской Федерации АО «НПО «Орион» (ГНЦ РФ НПО «Орион») при поддержке Минпромторга России, Минобрнауки России, Российского научного фонда, Ассоциации государственных научных центров «Наука».
Библиометрический анализ академической литературы по квантовой обработке информации
Authors: Терехов А.И.
Published: September 2024

Рассмотрены исторические вехи и выполнен библиометрический анализ развития исследований в области квантовой обработки информации в период 1990–2020 годов. В центре внимания глобальный выход научных публикаций, продуктивность отдельных стран и организаций, международная научная кооперация. С помощью библиометрических индикаторов показаны: динамизм развития области, высокая степень концентрации исследований и международных научных связей, участие в них, наряду с университетами и академическими организациями, крупных корпораций, особенно из Японии и военно-­исследовательских структур, в первую очередь, из США. Для России характерны: высокая концентрация исследований в столичных агломерациях и их существенная интернационализация; ведущий вклад РАН и растущая роль университетов в развитии научной базы квантовых технологий, пока еще слабая вовлеченность в исследования российского коммерческого сектора. Источниками информации для анализа послужили библиографические базы данных Web of Science Core Collection и SCOPUS.
Применение оптических методов для оценки физиологических повреждений флаговых листьев пшеницы
Authors: Баранова Е.Н. , Шелепова О.В. , Золотухина А.А. , Нестеров Г.В. , Судариков К.А. , Латушкин В.В. , Гулевич А.А.
Published: September 2024

В статье исследована возможность применения гиперспектральной и RGB-съемки в качестве быстрого и надежного метода определения содержания хлорофиллов для оценки показателей состояния фотосинтетического аппарата. Приведены результаты исследования связей между спектральными характеристиками отражательной способности флаговых листьев пшеницы, характеристиками их цвета и содержанием хлорофилла в условиях наличия и отсутствия затопления. Установлено, что наиболее точная оценка состояния растений может быть построена на основе вегетационного индекса NDVI705, полученного путем обработки гиперспектральных данных.
Migración laboral internacional de las mujeres sinaloenses. Una revisión de la literatura con una perspectiva feminista
Authors: Montoya Zavala Erika Cecilia
Published: September 2024

El objetivo de este artículo es analizar la participación en la migración internacional laboral de las mujeres sinaloenses. Se analizan los estudios sobre las sinaloenses en distintos nichos laborales: su participación en el mercado global de la costura y del cuidado; evidenciamos la participación de las sinaloenses en el proceso de productos pesqueros como la jaiba, y su incursión empresarial y de autoempleo como estilistas. Todo esto en un contexto de desigualdades laborales, las cuales ponen a las mujeres en desventaja económica y social. Los estudios revelan que las mujeres sinaloenses aportan su fuerza laboral en los mercados globales, y sus ingresos mejoran las condiciones de vida, salud y educación de sus familias. Sin embargo, las instituciones gubernamentales no reconocen sus aportes ni coadyuvan a aminorar las dificultades presentadas en sus trayectorias laborales. Este artículo está compuesto de tres apartados: 1) donde se esboza una perspectiva feminista para analizar a las sinaloenses en el mercado laboral global; 2) la descripción de las nuevas tendencias de la participación laboral de las mujeres, y, 3) la realización de un análisis de la literatura sobre la participación laboral de las sinaloenses migrantes en EUA.
Prevenção e controle das infecções relacionadas à assistência à saúde e de SARS-CoV-2 no contexto de trabalho dos cirurgiões-dentistas da Estratégia Saúde da Família, em município de grande porte do Nordeste brasileiro
Authors: Araújo Melo Elizabete , De Medeiros Aquino Tomaz , De Almeida Maria Eneide Leitão , Florêncio Caroline Mary Gurgel Dias , Arrais Paulo Sergio Dourado
Published: September 2024

Introduction: The health emergency related to the COVID-19 pandemic in Brazil and around the world, brought the need to reassess and implement new measures to protect the worker health. Objective: To analyze the work context of dentists from the Family Health Strategy (ESF) regarding the prevention and control of Healthcare-associated Infections (HAI) and SARS-Cov-2. Methods: This cross-sectional study was conducted with primary care dentists in Fortaleza, Ceará, in Northeast Brazil. In order to identify the sample of dentists from the ESF, a sample calculation was carried out, and 103 dentists participated. The selection of participants was carried out through a systematic probabilistic sampling. Data collection was carried out from June 8 to August 23, 2022, through an electronic questionnaire, which was accessed and completed electronically by a computer or smartphone, with questions that evaluated the offer of Personal Protective Equipment (PPE), equipment and infrastructure necessary for the good performance of the profession and the health conditions of workers in this context. A descriptive analysis was performed. Results: A total of 29.1% of respondents belonged to COVID-19 risk group. Overall, most participants had taken both doses and one (46.6%) or both (50.2%) booster doses and were vaccinated against influenza (81.6%). There is no 100.0% adherence to any of the PPE recommended by health authorities or by dentists. The availability of sufficient quantities of PPE in the service was always below the recommended level, and, in all situations, the quality of the PPE was considered questionable, potentially compromising work safety. Deficiencies related to the provision of equipment, devices, and infrastructure necessary for good performance were also verified. Conclusions: Despite the good vaccination practices of professionals, deficiencies in the process of implementing standards that provide for good practices in dental procedures were identified and needed to be implemented to avoid the risks inherent in the profession.
O MÉTODO INVESTIGATIVO COMO ESTRATÉGIA PARA AVIVAR O INTERESSE DOS ESTUDANTES SOBRE A REPRODUÇÃO VEGETAL
Authors: Paixão Geovane da Silva , Aoyama Elisa Mitsuko
Published: September 2024

A curiosidade impulsiona o ser humano, por isso, é essencial utilizar métodos investigativos com os estudantes, tendo em vista que estes contribuem para aguçar o desejo de questionamento e compreensão, desenvolvendo assim o pensamento crítico. A Botânica é um conteúdo da Biologia que desperta irrelevante interesse ou curiosidade dos estudantes. Nessa perspectiva, foi aplicada na 3ª série do Ensino Médio uma sequência de atividades investigativas sobre o conteúdo de biologia/reprodução vegetal, com o objetivo de avaliar a percepção dos estudantes acerca da importância do processo de polinização das Angiospermas, com o propósito de despertar a curiosidade e autonomia na construção do pensamento científico. A atividade foi desenvolvida em 3 aulas de 50 minutos cada. Na aula I, os estudantes realizaram um estudo de caso contendo uma sequência de imagens sobre a reprodução da rosa do deserto e foram motivados, por meio de questões norteadoras, a levantarem suas hipóteses. Na aula II, os estudantes produziram e apresentaram os cartazes com os temas pesquisados: reprodução sexuada/polinização, estaquia e enxertia. Durante a aula III, houve a realização de práticas experimentais sobre as temáticas pesquisadas. O Ensino de Botânica pode se tornar mais estimulante, participativo e divertido, com a utilização de metodologias não tradicionais. Com a realização dessa sequência metodológica, é possível concluir que as atividades investigativas contribuem para o desenvolvimento da capacidade argumentativa, tornado os estudantes sujeitos ativos do processo ensino-aprendizagem.
Restorative Justice Approach as an Alternative Criminal Case Resolution in Realizing Effective and Efficient Justice
Authors: Wahyudhi Dheny , Rahayu Sri , Sudarti Elly , Liyus Herry
Published: September 2024

This research aims to find out how the regulation of restorative justice as an alternative in resolving effective and efficient criminal cases and to find out how the settlement of criminal cases through a restorative justice approach in realizing effective and efficient justice. For this reason, researchers are interested in conducting research with the title restorative justice approach as an alternative to criminal case settlement in realizing effective and efficient justice. This research is a normative juridical research. The results of the study found that the regulation of rhetorative justice is regulated internally in each law enforcement institution of the police, prosecutor's office and court. The orientation is no longer on punishment but shifts to restoring the original situation through peace efforts of the parties, both victims, perpetrators and communities affected by criminal acts. so that it can present an effective and efficient justice both in terms of time and costs incurred. Suggestions so that the settlement of criminal offenses with a restorative justice approach runs effectively and efficiently, it is necessary to equalize the perceptions of each law enforcement agency, both the police, prosecutors and courts regarding what criminal offenses can be resolved through a restorative justice approach and the time period given in resolving criminal offenses with a restorative justice approach and needs to be regulated in the form of a law.
Implementation of Science Literacy Through Eclipse Diorama Project in Grade VI at Supriyadi Elementary School Semarang
Authors: Salsabila Shabrina , Setiyono Yuuki Chleo Pratama , Damayani Aries Tika , Azizah Mira
Published: September 2024

This study explores the implementation of an eclipse diorama project as a strategy to enhance students' scientific literacy. In the Contact phase, the teacher introduces the phenomenon of solar eclipses, sparking students' curiosity. In the Curiosity phase, students are given the opportunity to delve deeper into the topic, developing their inquiry skills. The Elaboration phase involves students in diorama projects, allowing them to apply their knowledge in a practical context. A descriptive qualitative research method is used to observe these stages. It was found that through this approach, students' motivation increased, their inquiry skills were enhanced, and their understanding of scientific concepts deepened in three steps. Thus, the implementation of the eclipse diorama project provides holistic understanding and a profound learning experience for students, preparing them to tackle scientific challenges and the demands of the 21st century.
Integrating Islamic Spirituality into Management Control Systems: A Case Study of Sharia-Based Leadership
Authors: Tatik Tatik , Falikhatun Falikhatun
Published: September 2024

This study aims to explore the practice of Management Control Systems (MCS) rooted in Islamic spiritual values. Utilizing an interpretive qualitative method with a single case study approach, data were collected through interviews, observations, and document analysis. The analysis of MCS was guided by principles derived from Islamic spirituality. The findings reveal that the spiritual values of the leaders, deeply influenced by the Al-Qur'an, Shiroh Nabawi, and their engagement with various Islamic communities, foster spiritual maturity. This spiritual foundation shapes wise leadership and results in an MCS that effectively steers the organization towards its intended goals. The implications of this research suggest that Muslim leaders should integrate Islamic character into the design of MCS, ensuring that organizations operate effectively to achieve both worldly and spiritual objectives, ultimately contributing to the well-being of the broader universe. The novelty of this study lies in its provision of new insights into the expression of MCS practices based on Islamic spirituality, the development of Islamic leadership character, and the connection between MCS and Sharia-compliant agreements.
Addressing Compliance: Does Supervision Foster Patient Adherence in an Ergonomic Exercise Program? - A Narrative Review
Authors: B Linder
Published: September 2024

Patient compliance is essential in creating optimal results in an Ergonomic Exercise Program. Unfortunately, there is little research into how to best achieve patient compliance. This narrative review explores the positive relationship between patient supervision and compliance in Home Exercise programs. This review also explores several types of supervision that are possible, (Patient Partnership, Experiential Learning, Written or Pictorial Communication, etc). Writing off poor results in a health care program as being due to patient noncompliance is an effort to deny personal responsibility for that failed program. Instead, the clinician should take personal responsibility in helping their patient achieve compliance