bluuebunny/crossref_metadata_2025 huggingface dataset:
Structure-Based Bioactive Phytochemical Design from Ayurvedic Formulations Towards Spike and Mpro Druggable Targets of SARS-CoV-2
Authors: Pushkaran Anju Choorakottayil , EN Prajeesh Nath , Nair Shantikumar V , P Rammanohar , Mohan C Gopi
Published: October 2020

The present COVID-19 global crisis invoked different disciplines of the biomedical research community to address the contagious human to human viral transmission and infection severity. Traditional or de novo drug discovery approach is a very time consuming process and will conflict with the urgency to discover new anti-viral drugs for combating the present global pandemic. Modern anti-viral drugs are not very effective and show resistance with serious adverse effects. Thus, identifying bioactive natural ingredients (phytochemical) from different medicinal plants or Ayurvedic formulations provides an effective alternative therapy for SARS-CoV-2 viral infections. We performed structure-based phytochemical design studies involving bioactive phytochemicals from medicinal plants towards two key druggable targets, spike glycoprotein and main protease (Mpro) of SARS-CoV-2. Phyllaemblicin class of phytocompounds showed better binding affinity towards both these SARS-CoV-2 targets and its binding mode revealed interactions with critical amino acid residues at its active sites. Also, we have successfully shown that the SARS-CoV-2 spike glycoprotein interaction towards human ACE2 receptor as its port of human cellular entry was blocked due to conformational variations in ACE2 receptor recognition by the binding of the phytocompound, Phyllaemblicin C at the ACE2 binding domain of spike protein. Our study shows that the Phyllaemblicin class of phytochemicals can be a potential dual inhibitor of spike and Mpro proteins of SARS-CoV-2 and could be promising for the treatment of COVID-19.
Interaction of Synthetic Cannabinoid Receptor Agonists with Cannabinoid Receptor I: Insights into Activation Molecular Mechanism
Authors: Gavryushov Sergei , Bashilov Anton , Cherashev-Tumanov Konstantin , Kuzmich Nikolay , Burykina Tatyana , Izotov Boris
Published: October 2020

The manuscript of a paper entitled "Interaction of Synthetic Cannabinoid Receptor Agonists with Cannabinoid Receptor I: Insights into Activation Molecular Mechanism". The work describes computer simulations of activation of the Cannabinoid Receptor I at binding of its agonist ligands. The molecular mechanism of the receptor-ligand interactions and receptor's activation is explored. The study includes theoretical models construction, intense molecular dynamics simulations, comparison with experimentally-known data. Some conclusions allow for better understanding of G-protein-copupled receptor mechanism of transmembrane allosteric modulation.
Agnihotra-Yagya and numinous sound -Prototyping strategy for pandemic prevention
Authors: Pratiksha P. Rathod
Published: October 2020

Ayurveda management comprises of three categories, Yuktivyapashrya includes medication, Daivavypashray are Divine therapies and Satvavajay deals with mental health. Agnihotra -Yagya is one of the therapies of divine management. It is fire offering of medicinal herbs along with cyclic uttering of Sanskrit words by experts. Present study aims to provide prototype of strategy for pandemic prevention. Numinous sound in form of Mantra along with mechanical heating of Agnihotra produces shorter wavelength of electromagnetic spectrum range and set certain vibrations in presence of solar energy at tissue level which inactivate the viruses and other microorganism present in inner as well as outer environment.Relevant literature was searched and incorporated in the study. Agnihotra,Yagya, Mantra, electromagnetic waves and others were the main words used for the search.Putting medicinal substances in Agnihotra fire is a scientific method of transformation of matter into energy and the process may be referred as sublimation. It can be postulated that there is generation of electromagnetic spectrum under the influence of solar energy and sonic potential of Mantra, the numinous sound. Interaction between microwaves and biological tissues draws solution to inactivate airborne viruses thus creating certain vibrations converting the whole process into a scientific operation involving each tissue of human body along with minute particles of surrounding environment.Considering its multi-dimensional aspects, at small scale, Agnihotra can be recommended at homes, hospitals, public places in presence of experts on daily or weekly basis. By adapting this ritual with scientific perspective, pandemics can be prevented. It is difficult to test combined therapeutic effect of all medications used in Agnihotra. With the evidences suggesting antimicrobial, Neuro-dynamic and spiritual effects, Agnihotra cannot be ignored by young scholars.
Precautions and Importance of PPE - Assessment of Knowledge Among Dental Health Care Workers - A Questionnaire Based Study
Authors: Preethi G  , Abilasha R  , Dinesh Premavathy
Published: October 2020

Healthcare workers are at constant risk due to the infections which occur due to exposure of blood and other body fluids from infected patients. Standard precautions must be taken like maintenance of personal hygiene, use of personal protective equipment, etc. to stay safe. Thus, this study assesses the knowledge of health care workers on the importance of PPE in order to improve the awareness towards the usage of PPE during essential periods of risk. The study setting was done through an online survey among health care workers. The collected data were then analyzed in SPSS online software and the results were plotted in the form of bar graphs. From the data, it is inferred that knowledge of PPE among health care workers is well known in the majority of the responders. But more awareness must be created on the importance of PPE for the safety and welfare of all health care workers. Health care workers are at constant risk due to the infections which can occur due to exposure of blood and other body fluids. PPE plays a major role in protecting against these infections. Thus, it is important and mandatory to wear them on a daily basis for a safe and protective work environment.
Attitude towards cadaver demonstration among first-year dental students
Authors: Sneka S  , Yuvaraj Babu K  , Gayatri Devi R
Published: October 2020

Anatomical demonstration is one of the important parts of learning and understanding anatomy. It is considered an essential requirement in learning gross anatomy. It plays an important role in shaping medical and dental students attitude. The survey was conducted online. Questionnaires which consist of 18 questions were prepared and distributed through google forms. The study population consists of 100 first-year dental students. From the collected data, 73% of them have seen the cadaver, the remaining 26% of them had never seen the cadaver before. This study helps students to improve their attitude on cadaver demonstration. Cadaver demonstration is essential and indispensable in learning anatomy. This study helps in knowing the attitude of the students towards cadaver demonstration. From this study, it has been concluded that cadaver demonstration enhances the skill of thinking in a logical manner and also cadaver demonstration gives better results than cadaver dissection.
LA PRECARIEDAD DE LA POSESIÓN PRECARIA EN EL PERÚ LA DESNATURALIZACIÓN DEL CONCEPTO DE PRECARIO EN EL CASO PERUANO
Authors:   UNIVERSIDAD CATOLICA DE SANTA MARÍA, CAMARGOP RIEGA ALBERTO VITTORIO , VALDIVIA CORZO MARÍA GRACIA ,   UNIVERSIDAD CATOLICA DE SANTA MARÍA
Published: October 2020

The purpose of this article is to highlight the treatment of the precarious concept in the Peruvian legal system and the confusion that both legislators and judges have reached at the time of establishing its definition in civil legislation and binding jurisprudence through judicial precedents. Furthermore, the effects they have caused in Peruvian judicial practice and in society in general. Keywords: Possession, precarious, squatter, judicial precedent, loan contract, eviction, eviction.
MEDICAL OPINION IN THE SACRED "AVESTÀ"
Authors:   Urgench branch of theTashkent medical academy of the Republic of Uzbekistan, Makhmudova Mukhabbat
Published: October 2020

In cultural heritage the mankind holds a specific place Avest. It is the sacred book of Zoroastrianism, edinobozhy world religion, bore to people new spiritual bases, knowledge of their history, lunch life, treatment of diseases. Medical view and manual of Zoroastrians also until now are of great value in protection and maintaining human health, an obepecheniya of their safe and long life.
The essential "Star Wars"Philip Pullman's baroque aesthetics
Authors: Perrot Jean
Published: October 2020

This essay has a twofold purpose: to consider the issues of contemporary Young Adult literature addressed to “the children of the videosphere” within the context of globalized culture and to assess the importance of postmodern Baroque aesthetics in the “Star Wars” system of modern Letters and mass-media. Writers often resort to such aesthetics with the prospect of commercial hegemony, but some of them find their “distinction” (in Pierre Bourdieu’s delineation) through intertextuality – be it avowed or hidden – with the great masters of the past (William Blake and John Milton). We will investigate the secret workshop of Phillip Pullman’s His Dark Materials Trilogy and some of his other works, as well as Jostein Gaarder’s Sophie’s World and diverse literary productions. With their arresting butterflies as significant baroque emblems, these works provide a new and spellbounding vision of the Western hero and offer a new “reterritorialization” of Letters. More particularly, Philip Pullman’s literary gesture has been to extract the baroque message from the vulgarised versions of popular mass media and to give it a new distinction.Key words: Postmodern baroque, William Blake, picaresque, humour, parody, Philip Pullman, Jostein Gaarder.
Laura Orvieto et l'Histoire. Une intellectuelle florentine dans l'Histoire et pour l'Histoire
Authors: Paruolo Elena
Published: October 2020

Notre article concerne Laura Orvieto (1876-1953), une intellectuelle florentine juive, et analyse en particulier six de ses ouvrages destinés à la jeunesse dont le sujet est l’histoire et la mémoire partagée. Nous examinons d’abord les histoires grecques de héros et de dieux, c’est-à-dire les mythes (l’Histoire avant l’Histoire), les histoires de Rome et la première guerre mondiale dont l’auteur nous donne une vision qu’on pourrait définir comme irénique, c’est-à-dire pacifiante. Pour terminer nous nous concentrons sur la mission humanitaire pionnière et héroïque aussi bien que diplomatique et féministe de Florence Nightingale, qui avait beaucoup travaillé à l’organisation des hôpitaux militaires durant la guerre de Crimée. Mots Clés : Mythe, Histoire, histoires, guerre, littérature de jeunesse.
Les contes de Perrault illustrés par Doré et le jeu des différences
Authors: Chagrot Ghislaine , Moog Pierre-Emmanuel
Published: October 2020

Les illustrations très détaillées que Gustave Doré propose des récits de Perrault offrent l’intérêt de permettre de vérifier aisément ce qui diffère entre le texte et l’image. Cet exercice possède des vertus pédagogiques pour mieux comprendre et le texte et les enjeux de l’illustration. Il se déroule en trois étapes, consistant d’abord à établir le texte spécifique correspondant à l’image, puis à repérer les différences significatives entre les deux, enfin à évaluer l’impact que cela peut avoir sur la compréhension du texte, positivement ou négativement. A travers l’exemple de trois illustrations de contes de Perrault par Doré, nous examinerons dans quelle mesure l’infidélité de l’image entraîne une modification du sens du texte et offre l’opportunité d’un meilleur questionnement narratif. Ainsi, cette approche du conte par l’album, du texte par l’illustration, au-delà de son aspect ludique, inscrit cette démarche comparative dans une perspective pédagogique qui donne un statut heuristique à l’erreur et à l’anomalie.
Mots clés: Contes de Perrault, Gustave Doré, Conte merveilleux et illustration, Conte merveilleux et pédagogie, Petit chaperon rouge
Au-delà des genres: le cas de "Mélusine"
Authors: Charnay Bochra
Published: October 2020

Cet article explore un corpus construit autour du cycle mélusinien composé du roman de Jean d’Arras, de plusieurs versions orales du conte type 425 et de la légende poitevine. Il met en place une réflexion autour du concept de genre dans le cadre de l’enseignement universitaire de la Littérature de jeunesse. Il pose que les textes abordés séparément, présentent des invariants qui les rattachent à une catégorie générique identifiable par le destinataire en fonction de son horizon d’attente. En revanche, ce mêmes textes confrontés les uns aux autres, créent un brouillage entre leurs frontières, qui apparaissent comme poreuses, et il devient dès lors difficile de les classer dans un genre unique et bien délimité. C’est pourquoi, l’article souligne les limites du concept de genre de par son effet classificatoire et statique et lui substitue le principe de la généricité mis en place par Jean-Michel Adam et Ute Heidmann. Ce dernier, considéré comme plus souple et plus dynamique, met en évidence la richesse des interactions entre les discours et souligne le lien intergénérique qui procède à leur formation.
Mots clés : conte, roman, légende, Mélusine, genre, intergénéricité, transdiscursivité.
L’album en V.O. en cours de langue : de l’élève acteur au sujet lecteur en L2
Authors: Burgain Marie-France
Published: October 2020

L’album a souvent été utilisé comme support d’apprentissage en classe de langue à l’école primaireen France. Ses qualités linguistiques et stylistiques en font en effet un support de choix pour favoriserl’acquisition de lexique et de structures langagières en langue seconde mais également pour développerdes compétences phonologiques dans cette langue. Et ses images sont autant d’outils permettant defaciliter la compréhension et d’encourager la production.Il ne faudrait cependant pas réduire l’album à ses seuls contenus linguistiques. La question qui sepose alors est de savoir si l’album en V.O. ne pourrait pas permettre à l’élève de s’approprier autre choseque des faits de langue et si la perspective actionnelle ne pourrait pas encourager une exploitation pluslittéraire de l’album. En faisant de l’élève un acteur et en s’intéressant à sa façon de lire et de réécrirel’album, l’enseignant ne peut-il pas l’aider à développer également des compétences de lecteur en L2 ?Mots-clés : album, enseignement/apprentissage des langues, approche actionnelle, réécriture,sujet-lecteur
Receiver design for MIMO FSO communication systems with photon-counting detection
Authors:   , Mawla Rami Issam El
Published: October 2020

Optical wireless communication (OWC) constitutes a key technology for 5G wireless networks. OWC alleviates the radio frequency (RF) spectrum crunch problem by enabling communications in the visible, infrared and ultraviolet optical frequency bands for a variety of indoor and outdoor applications. Outdoor infrared OWC systems are widely referred to as free-space optical (FSO) communications that rely on line-of-sight transmissions of narrow laser beams. The FSO technology is license-free, easy-to-deploy, cost-effective and capable of delivering very high data rates. The major impairment that severely degrades the performance of FSO links is related to the random aspect of the atmosphere. Overcoming atmospheric turbulence-induced fading became the key research area where many solutions have been proposed and analyzed. These solutions include the multiple-input-multiple-output (MIMO) techniques.
Does Lebanon possess the capabilities to defend itself from cyber-theats? Learning from Estonia's experience
Authors:   , Barakat Kristofas
Published: October 2020

The growing danger of cyber-threats has forced many states to develop and strengthen their cyber-security capabilities. The complex nature of cyber-threats has a profound impact on traditional international relations, as many states today consider cyberspace as the greatest challenge to their national security. Research literature on cyberspace and cyber-threats is particularly limited in the case of Lebanon, despite Lebanon’s interesting cyber-threats history. The domination of traditional security dilemmas have restricted Lebanon from developing a successful cyber-security. The lack of attention and development for cyber-security has made Lebanon an appealing target for various actors to conduct their cyber-operations. The objective of the thesis is to determine whether Lebanon has the ability to defend itself from cyber-threats in spite of a missing cyber-security policy. The thesis offers an analysis of Lebanon’s current conditions with regard to cyber-security at various levels. The thesis employs the international legal framework on cybercrime, the Budapest Convention, in order to assess Lebanon’s capabilities to counter cyber-threats. Furthermore, this study utilizes Estonia, a small Baltic nation considered as one of the leaders in the field, as a comparative case to further examine Lebanon’s cyber-security and identify areas that would bolster Lebanon’s capabilities.
ATTITUDE TOWARDS RIGHT TO EDUCATION ACT AMONG HIGHER SECONDARY SCHOOL STUDENTS IN KANYA KUMARI DISTRICT
Authors: T Velam , S. Anitha
Published: October 2020

The investigator was conducted to study the attitude towards right to education act in higher secondary school students in kanyakumari district. The investigator collected data from kanyakumari district higher secondary school students randomly from different schools. The data obtained were analyzed by using appropriate statistical techniques such as mean, standard division, t-test, ANOVA, and level analysis. The findings reveals that there exists significant difference in Gender, Medium of instruction, Type of family and Type of school and there no significant difference in Religion.
A STUDY OF RELATIONSHIP BETWEEN INTERNET USAGE AND SELF-REGULATED LEARNING OF UNDERGRADUATES
Authors: Kute Meena Prakash , Palsamkar SadhanaPote
Published: October 2020

The present paper is based on the descriptive correlational research study which aimed to study the relationship between internet usage and self-regulated learning of undergraduates. The survey method was employed to collect the data from commerce, science and arts undergraduates of Mumbai University. The findings of present study showed that, there is significant relationship between internet usage and self-regulated learning of undergraduates. The relationship was found to be positive and negligible.
FACTORS INFLUENCING THE CONSUMERS TOWARDS BUYING MARUTI CARS IN THOOTHUKUDI DISTRICT
Authors: Selva Priya A.Antony , R.AnanthaLaxmi
Published: October 2020

With the explosion of the automobile industry, due to its globalization and liberalization, car manufacturers introduced much innovative and technological advancement in their models. Customers have started thinking to change over to the new models of cars, with related ease than before, to suit their changing life styles. Customer’s perception of service and quality of product will determine the success of the product or service in the market. With better understanding of customer’s perceptions, companies can determine the actions required to meet the customer’s needs. They can identify their own strengths and weaknesses, where they stand in comparison to their competitors, chart out the path future progress and improvement. Customer satisfaction measurement helps to promote an increased focus on customer outcomes and stimulate improvements in the work practices and processes used within the company. This paper focuses to find out the factors influencing the consumers towards buying Maruti cars in Thoothukudi district. The sample size of the study is sixty respondents from Thoothukudi district. The study quantitatively analyses the consumers’ buying behaviour, factors influencing the attitudes and behaviours of the consumers in buying Maruti car using primary data. Appropriate findings and suggestions are given in the paper.
FABRICATION AND TESTING OF A SEMI-MANUALLY OPERATED FISH SCALE REMOVER
Authors: Ablazo Michael Dave B. , Ampuan Richelle O. , Noble Rommel P. , Varela Benjamin D.
Published: October 2020

Commercial fish scale removers are very expensive.  This study was conducted in order to fabricate and test the performance of a low cost, stand-alone semi-manually operated fish scale remover.  The randomized complete block design (RCBD) quasi-experiment was used to test the capacity and efficiency of the semi-manually operated fish scale remover.  Three (3) different kinds of fish in Northern Samar (Bangus, Sagision and Kirawan) with three (3) different sizes of scales (Large, Medium and Small) were used in the testing of the fabricated fish scale remover at three (3) different speeds of the scaling drum (High, Medium and Low).  The results revealed that the higher the speed of the scaling drum, the higher is the scaling capacity of the manually-operated fish scale remover.  Likewise, the bigger the scales of fish being descaled, the higher is the scaling capacity of the manually-operated fish scale remover.  The average scaling capacity of the fish scale remover is higher than the average scaling capacity of an experienced fish vendors for kirawan and sagision but is lower than that of the experienced fish vendors for bangus.  On the other hand, the average scaling efficiencies of the machine for all the fish used in testing the machine were highest at medium speed setting of the scaling drum.  The cost and return analysis on the operation of the semi-manually operated fish scale remover revealed that it will have an annual net income of P 48,724.37, a payback period of 50 days, and a rate of return of 3.82.   The actual cost of constructing the semi-manually operated fish scale remover is ₱ 12,756.00.
Skeletal Dysplasia: an Analysis of Dwarfism in Ancient Egyptian Culture
Authors: Engele Kody
Published: October 2020

The purpose of this paper is to analyze dwarfism and its standing in ancient Egyptian society and culture. Dwarfism existed in ancient Egyptian society, but unlike other ancient societies, those with dwarfism were not blatantly discriminated against (Sullivan 2001). Individuals with dwarfism could hold many positions within society ranging from herdsmen and fishermen, to personal attendants in royal court (Kozma 2008). There is evidence of individuals with dwarfism dating back to the Badarian Period, with statues, sarcophagi, skeletons, and paintings all having been discovered (Kozma 2008). There are several prominent figures who have been studied in detail; Per-ni-ankh-w was an individual with high status in Egyptian society, and there is ample docu­mentation of him in texts, visual imagery, and skeletal evidence (Kozma 2008). Djeho was another individual who has been well documented and aided with burials (Kozma 2008). Individuals with dwarfism also had religious importance, including the gods Bes and Ptah (Kozma 2008). Individ­uals with dwarfism were also considered to hold magical significance, and this was seen in spells and religious texts (Kozma 2008). Additionally, there is an abundance of artistic representation of individuals with dwarfism, in the form of statues, sarcophagi, and visual images (Kozma 2008). The Walters Art Museum is also a significant holder of Egyptian art, with many depictions of dwarfism (Kozma 2010). These individuals were significant in ancient Egyptian society and were well documented in several forms.
Critical Review of Healing Elements: Efficacy and the Social Ecologies of Tibetan Medicine
Authors: Gowan Michelle
Published: October 2020

This article offers a critical review of Healing Elements: Efficacy and the Social Ecologies of Tibetan Medicine. The ethnography provides rich and comprehensive insights regarding the triumphs and tribulations of Sowa Rigpa (traditional Tibetan medicine) as the medical system is translated across diverse contexts to ensure its continuity within the globalized world; however, these insights can be broadened by more deliberately acknowledging and investigating the (post)colonial subtexts underlying these translations. Incommensurability emerges throughout the ethnography in the form of tensions that arise as tacit knowledge is translated to explicit knowledge in the quest for legitimization. It is argued that expounding the nature of this incommensurability by engaging with rather than rejecting polarized notions of “traditional” and “modern” paradigms can reveal that non-biomedical medical systems and medically pluralistic contexts more broadly are inundated by (post)colonial processes. Borrowing Blaser’s (2013) notion of “Sameing,” it is demonstrated that translation involves (post)colonial processes of assimilation, as Sowa Rigpa is rendered visible through Good Manufacturing Practices (GMP), and appropriation, as it is made palatable through pharmaceutical commodification. Furthermore, it is argued that these processes mobilize  mimesis and essentialization to transform Sowa Rigpa into a system that is both legitimized and acquiescent to the imperatives of varying external regimes. The simultaneity of these effects and the position that they are not mutually exclusive is asserted throughout the review as further evidence of (post)colonization.
The Potential for Urban Vegetation to Mitigate Ambient Air Pollution Threats to Public Health
Authors: Patel Sonak
Published: October 2020

This paper assesses the threat that ambient air pollution poses to urban public health and the potential role of urban vegetation to mitigate those threats. Air pollution is a major global risk to health, especially in urban areas. In this paper, four major air pollutants were assessed: particulate matter, tropospheric ozone, nitrogen dioxide, and sulfur dioxide. These pollutants were found to have several adverse effects, including increasing mortality and respiratory morbidity. These pollutants come from a variety of sources, but a major contributor in urban areas is the burning of fossil fuels in automobiles. The adverse health effects of pollution are expected to grow as climate change worsens air quality. Research and case studies find that urban vegetation can filter air and remove pollutants through deposition and stomatal uptake. The effectiveness of air pollution removal is dependent upon specific variables, including leaf characteristics, type of vegetation, and seasons. Urban vegetation may worsen air quality in some cases due to slowing ventilation and producing biological volatile organic compounds. While urban vegetation has potential to mitigate ambient air pollution, conducting site specific research is needed when implementing greenspace policies.
Medical Tourism: A History and Overview of the Industry and the Case Study of Addiction Recovery in Spain
Authors: Haykowsky Kazimir
Published: October 2020

This paper focuses on the emerging global market in medical tourism. The industry continues to expand and become increasingly profitable with greater popular support. This paper conveys the findings of a literature review on the origins, history and contemporary development of the industry. It explores the rationale and access of the medical tourist, and the purported benefits and costs to involved parties including patients, caregivers, citizens and governments. Ultimately it reveals that this phenomenon leads to lower costs, better care, discretion and leisure benefits to wealthy and mobile international clients while reducing available resources and quality of care for residents of host countries, which are mostly low and middle income countries and potentially costing source countries in aftercare. This paper examines the case study of international treatment for addiction in Spain and analyze two websites advertising the treatment for their use of promotional tactics, the importance of place and the relevance of Wilbert Gesler’s therapeutic landscape concept in marketing services. This reveals that international mobility allows businesses to profit from permissive legal environments and popular therapeutic landscapes abroad.
Ice District
Authors: Woodruff David
Published: October 2020

Ice District
The Skinny on Obesity: A need for a comprehensive diagnostic of obesity beyond self and health variables to include social and environmental strategic drivers
Authors: Hendershot Elle
Published: October 2020

The rapid increase in the number of obese adults and children in both developed and developing countries is alarming and will strain health resources in the future. A review of pertinent social and built environmental influences that contribute to the prevalence of this chronic disease is examined with reference to current literature. This paper explores the relationship between factors of the built and social environments that ultimately lead to the creation of obesogenic environments. Recognizing the importance of human interaction, coupled with genetic factors, with the built environment in addressing obesity is an important variable, the author argues that rather than evaluating obesity with a retrospective approach, a forward thinking approach in creating built environments which entice human action in the environment should be an ongoing premise in fighting obesity.
Kelly Ramsey Building
Authors: Soans Ranon
Published: October 2020

Kelly Ramsey Building
DIY Urbanism: Influences & Impacts on Community Planning
Authors: Shuttle Steven
Published: October 2020

‘Do It Yourself’ (DIY) urbanism is usually initiated by community members using a grassroots approach to change urban areas. Community planning involves making decisions about urban areas. This paper examines topics regarding DIY urbanism and community planning. Community engagement, neoliberalism and municipal support are key influences of DIY urbanism related to planning. DIY urbanism impacts the planner’s role as well as the relationships between planners, communities and municipalities. Three Canadian examples of DIY urbanism are introduced, including the Urban Repair Squad, PARK(ing) Day, and CITYlab. Discussion focuses on the opportunities and potential challenges of DIY urbanism for planners to consider. Potential challenges include public safety and municipal liability. Recommendations for planners regarding DIY urbanism are provided. DIY urbanism can be beneficial if planners work collaboratively and focus on small scale, low cost improvements.
Antibacterial Activity of Leaf Extracts of Anredera cordifolia (Ten.) Steenis and Muntingia calabura L. Against Streptococcus pneumoniae
Authors: Nasution Nuke Annisa , Artika I Made , Safari Dodi
Published: October 2020

Antibacterial resistance in Streptococcus pneumoniae has been increasing and is one of ongoing global concern.  The need to find new antibacterial agents against Streptococcus pneumoniae is of paramount importance. Medicinal plants are prospective sources of antibacterial agents. The aims of the present study were to determine the activity of leaf extraxt of Anredera cordifolia (Ten.) Steenis and Muntingia calabura L. against Streptococcus pneumoniae.  Leaves of Anredera cordifolia (Ten.) Steenis were extracted using 96% ethanol, while the leaves of Muntingia calabura L were extracted using 100% methanol.  The leaf extracts of the two plants obtained were bioassayed for antibacterial activity against Streptococcus pneumoniae ATCC 49619 and a clinical isolate Streptococcus pneumoniae PU 067.  Results showed that leaf extracts of both Anredera cordifolia (Ten.) Steenis and Muntingia calabura L. have antibacterial activity in vitro against Streptococcus pneumoniae ATCC 49619 at crude extract concentrations of 25%, 50%, 75% and 100% (w/v). Both plants extracts showed strongest activity against S. pneumoniae ATCC 49619 at extract concentration of 75%.   In addition, the extracts of both plants have inhibitory activity against growth of the clinical isolate Streptococcus pneumoniae PU 067. Both plant extracts showed strongest activity against S. pneumoniae PU 067 at extract concentration of 100%.  Therefore, leaf extracts of Anredera cordifolia (Ten.) Steenis and Muntingia calabura L. can potentially be used as a source of antibacterial agent for Streptococcus pneumoniae.

Keywords: Antibacterial agent, Anredera cordifolia (Ten.) Steenis, Muntingia calabura L., Streptococcus pneumoniae.
QUALIDADE DE VIDA EM CRIANÇAS COM CARDIOPATIA CONGÊNITA ACIANOGÊNICA
Authors:   Universidade Anhembi Morumbi, São Paulo, Brasil., Schmidtt Bastos de Oliveira Andréia , Sarti Banffy Sofia ,   Universidade Anhembi Morumbi, São Paulo, Brasil., Camelo Filho Célia Maria ,   Universidade Federal de São Paulo (UNIFESP), São Paulo, Brasil., Garcia Barbosa Lene ,   Universidade Anhembi Morumbi, São Paulo, Brasil
Published: October 2020

Objetivos:O presente trabalho tem como objetivo avaliar a qualidade de vida relacionada à saúde em crianças com cardiopatia congênita e quais de seus as-pectos são mais prejudicados na população estudada. Métodos:Trata-se de um estudo transversal, realizado com pacientes na faixa etária pediátrica, diagnosti-cadas com cardiopatia congênita acianogênica, atendidas num ambulatório de cardiologia pediátrica. A qualidade de vida dos pacientes foi avaliada através de PedsQL™ Generic Core Scales 4.0 e PedsQL™ Cardiac Module, além de um ques-tionário contendo aspectos sociais e clínicos, e doDenver II. Resultados: A partir da análise do PedsQL, todos os pacientes tiveram uma perda de 20 pontos ou mais em pelo menos duas das seis dimensões de qualidade de vida. Entre os pacientes, 69,23% apresentaram pontuação menor que 50 em pelo menos uma dimensão. A menor pontuação obtida foi em relação à ansiedade com o tratamento -média de 48,60 pontos - seguida por problemas de comunicação - média de 52,20 - e problemas de compreensão, 52,94. Além disso, 27% dos pacientes apresentaram alterações do desenvolvimento neuropsicomotor de acordo com o Denver II. Conclusão:Os resultados encontrados neste estudo corroboram trabalhos anteriores a respeito da forte correlação entre cardiopatias congênitas e alterações neurocognitivas que levam a prejuízos e sequelas futuras e impactam diretamente a vida das crianças cardiopatas. Na população estudada, fica clara a necessidade de acompanhamento especializado do desenvolvimento neuropsicomotor (DNPM).
ANGINA INSTÁVEL RELACIONADA À SUSPENSÃO DE ANTIAGREGANTE PLAQUETÁRIO PARAREALIZAÇÃO DE CIRURGIA ORAL
Authors:   Departamento de Cirurgia, Estomatologia, Patologia e Radiologia, Faculdade de Odontologia de Bauru, Universidade de São Paulo,São Paulo, SP, Brasil., Rodrigues Manzano Brena , Aguilar Quispe Reyna ,   Departamento de Cirurgia, Estomatologia, Patologia e Radiologia, Faculdade de Odontologia de Bauru, Universidade de São Paulo,São Paulo, SP, Brasil., Moura Chicrala Gabriela ,   Departamento de Cirurgia, Estomatologia, Patologia e Radiologia, Faculdade de Odontologia de Bauru, Universidade de São Paulo,São Paulo, SP, Brasil., Buhatem Medeiros Frederico ,   Departamento de Odontologia da Sociedade de Cardiologia do Estado de São Paulo (SOCESP). São Paulo, SP, Brasil, Gomes Caetano Fabiana ,   Unidade de Terapia Intensiva, Hospital Estadual de Bauru, Bauru, SP, Brasi, da Silva Santos Paulo Sérgio ,   Departamento de Cirurgia, Estomatologia, Patologia e Radiologia, Faculdade de Odontologia de Bauru, Universidade de São Paulo,São Paulo, SP, Brasil.
Published: October 2020

A angina instável (AI) é causa comum de internação hospitalar e mortalidade, e seu tratamento inclui o uso de antiagregantes plaquetários (ATP) e/ou anticoagulantes. A realização de cirurgia oral em indivíduos que fazem uso desses medicamentos é um desafio diante do risco de sangramento versus risco de eventos tromboembólicos como a AI. Neste relato de caso, um homem de 61 anos foi internado na Unidade de Terapia Intensiva por AI apresentando queixa de sangramento bucal e histórico de extração dentária há dois dias associado à interrupção de ácido acetilsalicílico 100 mg durante 20 dias antes da cirurgia oral. A história médica revelou hipertensão arterial sistêmica, doença arterial coronariana, diabetes mellitus tipo I, infarto agudo do miocárdio e AI há dois meses. Para controle do sangramento bucal, primeiramente, a equipe médica realizou manobras hemostáticas locais com compressão de gaze e infiltração local com adrenalina, mas sem sucesso. Pela persistência do sangramento bucal, a equipe de odontologia foi contatada e observou-se sutura em posição na região dos dentes pré-molares e primeiro molar em maxila esquerda com sangramento espontâneo via sulco gengival do dente adjacente.A conduta odontológica consistiu na introdução de ácido tranexâmico tópico, o que controlou o sangramento bucal. O paciente recebeu alta hospitalar sem queixas. Consi-derações finais: a suspenção de ATP para cirurgia oral de baixo risco de sangramento levou à AI, aumentando o risco de mortalidade, sendo que o sangramento bucal pode ser eficazmente controlado com medidas hemostáticas locais.
ESPIRITUALIDADE: DO CONCEITO À ANAMNESE ESPIRITUAL E ESCALAS PARA AVALIAÇÃO
Authors:   Faculdade de Ciências Médicas da Universidade do Estado do Rio de Janeiro. Rio de Janeiro, RJ, Brasil., Esporcatte Roberto ,   Hospital PróCardíaco. Unidade Cardiointensiva. Rio de Janeiro,RJ, Brasil.,   Grupo de Estudos em Espiritualidade e Medicina Cardiovascular (GEMCA) da Sociedade Brasileira de Cardiologia. Rio de Janeiro, RJ, Brasil, Avezum Jr Álvaro ,   Grupo de Estudos em Espiritualidade e Medicina Cardiovascular (GEMCA) da Sociedade Brasileira de Cardiologia. Rio de Janeiro, RJ, Brasil,   Hospital Alemão Oswaldo Cruz. Centro Internacional de Pesquisa. São Paulo, SP, Brasil,   Universidade de São Paulo. Departamento de CardioPneumologia. São Paulo, SP, Brasil., Moreira-Almeida Alexander ,   Faculdade de Medicina da Universidade Federal de Juiz de Fora – UFJF. - NUPES - Núcleo de Pesquisas em Espiritualidade e Saúde. Juiz de Fora, MG, Brasil., Masciarelli Francisco Pinto Ibraim ,   Grupo FLEURY. São Paulo,SP, Brasil.,   Métodos Diagnósticos do Instituto Dante Pazzanese. São Paulo,SP, Brasil., Hideyuki Moriguchi Emilio ,   Grupo de Estudos em Espiritualidade e Medicina Cardiovascular (GEMCA) da Sociedade Brasileira de Cardiologia. Rio de Janeiro, RJ, Brasil.,   Faculdade de Medicina da Universidade Federal do Rio Grande do Sul (UFRGS). Rio de Janeiro,RJ, Brasil
Published: October 2020

A integração da espiritualidade de forma sistemática e profunda na prática clí-nica tem sido recomendada como forma de transmitir aos pacientes a certeza de sua posição no centro dos cuidados. A maioria dos pacientes tem alguma forma de religiosidade/espiritualidade que influencia tanto os processos envolvidos na manutenção da saúde e no adoecimento, quanto nas formas de enfrentamento das adversidades. Muitos pacientes e seus familiares têm demandas na esfera da espiritualidade, principalmente em doenças graves, crônicas ou próximas do fim. Há um conjunto de evidências que indicam que diversas expressões da espirituali-dade têm impacto significativo na saúde e no bem-estar, que se associa a menores níveis de mortalidade geral, depressão, suicídio e uso de substâncias e a aumento da qualidade de vida. Além de grande lacuna na formação médica para realizar a anamnese espiritual adequada, muitos profissionais têm incertezas sobre a recep-tividade dos pacientes, a percepção de invasão de privacidade ou a imposição de religião, dificuldades na linguagem da espiritualidade, divergências de crença ou mesmo falta de tempo. Para que essa abordagem não seja conflitante há que haver preparo e aceitação tanto por parte dos profissionais de saúde, quanto dos pacientes e cada momento de interação deve ser transformado em oportunidade para uma avaliação natural e sensível da espiritualidade. Neste artigo, os autores apresentam diversos conceitos sobre espiritualidade e propostas para o rastreamento e anamnese baseadas em questionários e escalas disponíveis tanto para prática clínica como para pesquisa.
ENFERMIDADE MORAL: COMO PENSAMENTOS E SENTIMENTOS INFLUENCIAM A SAÚDE CARDIOVASCULAR
Authors:   Hospital Alemão Oswaldo Cruz. Centro Internacional de Pesquisa.São Paulo, SP, Brasil, Avezum Jr Álvaro , Borba Mário ,   Cardio-Clínica do Vale, Lajeado, RS, Brasil., Lantieri Carla ,   Faculdade de Medicina do ABC. Divisão de Cardiologia. Santo André, SP, Brasil., Moreira Dalmo ,   Instituto Dante Pazzanese de Cardiologia. Divisão de Eletrofisiologia, São Paulo, SP, Brasi, Bedirian Ricardo ,   Universidade Estadual do Rio de Janeiro. Departamento de Clínica Médica. Rio de Janeiro, RJ, Brasil
Published: October 2020

A espiritualidade tem sido pesquisada como paradigma para entendimento do adoe-cimento cardiovascular (CV) e intervenção terapêutica em potencial. Como pensamos e sentimos pode estar associado à ocorrência ou não de doença CV. Ela deve ser vista como um aspecto dinâmico e intrínseco da humanidade que, por meio de pensamentos, atitudes, ações e reações nas circunstâncias da vida, faz com que as pessoas procurem significado, propósito e transcendência. A enfermidade refere-se à resposta subjetiva do paciente ao fato de não estar bem mesmo não havendo confirmação laboratorial ou clínica, mas que pode ser avaliada objetivamente por meio de questionários ou escalas. Há correlação com alterações bioquímicas, hormonais ou com desfechos clínicos depen-dendo da intensidade, da condição clínica avaliada ou de período de observação. Existem escalas e questionários para avaliação de enfermidade moral, como por exemplo, gratidão, disposição ao perdão, propósito de vida e otimismo. A espiritualidade está associada independentemente à mortalidade CV, como a disposição ao perdão se associa à doença arterial coronariana, gratidão com melhores desfechos clínicos em insuficiência cardíaca e a raiva está associada com disfunção ventricular e diabetes. As intervenções baseadas em perdão e gratidão têm mostrado benefícios em parâmetros correlacionados com a saúde mental, saúde física e qualidade de vida. Há necessidade de estudos randomizados em pacientes com doença CV que avaliem intervenções baseadas em solidariedade atitudinal sobre a melhora da sobrevida livre de eventos.Cientificamente, podemos enunciar: Quando começamos a adoecer? Inicialmente, teríamos o desequilíbrio espiritual na intimidade de nossa consciência, por causa das escolhas e enfrentamento das situações cotidianas que vivenciamos? Estamos fazendo de nosso ambiente moral nosso campo de pesquisa em Cardiologia e postulando que esse modelo, que inclui a modificação de condutas comportamentais de cunho moral, permitiria a prevenção da doença CV.
ASSOCIAÇÃO ENTRE SAÚDE MENTAL E SAÚDE CARDIOVASCULAR: DO CONCEITO À IDENTIFICAÇÃO DE PREDITORES INDEPENDENTES
Authors:   Hospital Israelita Albert Einstein, São Paulo, SP, Brasil, Wajngarten Mauricio , Andrei Anna Maria ,   Hospital Israelita Albert Einstein, São Paulo, SP, Brasil, Almeida Dirceu ,   Universidade Federal de São Paulo. São Paulo, SP, Brasil, Bittencourt das Virgens Cláudio Marcelo ,   Universidade do Estado da Bahia. Salvador, BA, Brasil, Rizzi Coelho Filho Otávio ,   Universidade Estadual de Campinas. Campinas, SP, Brasil
Published: October 2020

A presente revisão tem por objetivo fornecer subsídios conceituais sobre a interco-nexão entre o binômio saúde (ou doença) mental e saúde cardiovascular. Para tanto foram apresentados alguns estudos experimentais ilustrativos e discutidas as principais hipóteses fisiopatológicas que poderiam explicar essa interconexão, incluindo a síndrome de Takotsubo como modelo. A fim de buscar a identificação de preditores independentes, os autores utilizaram dados epidemiológicos que indicam preditores dos vínculos bidire-cionais entre as doenças mentais, principalmente depressão e ansiedade e as doenças cardiovasculares, em especial a doença da artéria coronária.
RESILIÊNCIA, CARDIOLOGIA, ODONTOLOGIA INTERDISCIPLINAR E SOCIAL
Authors:   Associação Brasileira de Cirurgiões Dentistas Antroposóficos - IDEIA.São Paulo, SP, Brasil, Lulo Galitesi Celia Regina ,   Clínica Odontolulogia. São Paulo, SP, Brasil., Timerman Lilia ,   Instituto Dante Pazzanese de Cardiologia. São Paulo, SP, Brasil.,   Sociedade de Cardiologia do Estado de São Paulo. São Paulo, SP, Brasil.
Published: October 2020

Fatores psicossociais e aspectos comportamentais dos pacientes com doenças cardiovasculares e/ou orais interferem na maior ou menor motivação à adesão e ao cumprimento das recomendações médicas e odontológicas para cuidados essenciais de saúde, tais como tomar os devidos medicamentos, manter o autocultivo diário dos bons hábitos, cumprir atividades salutogênicas orientadas que reverberem bem-estar e saúde, desde simples ações como tomar um pouco de sol diariamente até ações mais elaboradas como incluir disciplina e, por exemplo, mais dedicação aos ritmos diários, atividades físicas e maior atenção ao autocuidado e ao padrão comportamental. Nessa perspectiva, a saúde do indivíduo inclui sua capacidade de ação e de adaptação resiliente em resposta aos estímulos que recebe do meio em que vive e se relaciona. Consideramos a vida em sociedade, as trocas afetivas, culturais e atividades em grupo importantes pilares para promoção de saúde porque geram movimento e estímulo a mudanças comportamentais. A relação multiprofissional entre cardiologista e equipe interdisciplinar antroposófica é um essencial aporte tanto dentro de distintas áreas da saúde e afins, como dentro da mesma profissão no caso entre a odontologia hospitalar e a odontologia antroposófica. O bom trabalho técnico-profissional com equipe interdis-ciplinar, usando linguagens apropriadas sob visão sistêmica, busca promover um vínculo profissional para considerar a totalidade do ser humano que existe por detrás daquele paciente que vem em busca de cura; a quem, todavia, deve-se perguntar se existe real e sincero propósito de se curar. Os fatores que mantêm as pessoas com maior gestão sobre seu bem-estar geram, em grande escala, reflexo positivo ao coletivo. Não existe saúde social sem saúde individual.
A ESPIRITUALIDADE COMO FATOR DE FORTALECIMENTO NA CONSTRUÇÃO SOCIAL DO PAPEL DE CUIDADOR DOMICILIAR DE PACIENTES EM CUIDADOS PALIATIVOS
Authors:   Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo. Divisão de Serviço Social Médico. São Paulo, SP, Brasil., Andrade Letícia
Published: October 2020

O cuidado paliativo hoje no Brasil apresenta-se como objeto de discussão, normatiza-ção e organização de diferentes ações com o intuito de torná-lo cada vez mais efetivo. A assistência domiciliar na área da saúde, hoje, é uma alternativa de cuidados para diferentes populações e com objetivos diversos, assim como representa uma das estratégias da política de saúde brasileira que mais vem se desenvolvendo nos dias atuais. A junção dos cuidados paliativos e a assistência domiciliar é o foco central desse trabalho, tendo como objetivo entender como se efetiva tal prática e como o familiar organiza-se para o assumir da referida atenção. A metodologia utilizada foi a História Oral, cujo enfoque é o sujeito e sua experiência, relatada para o pesquisador. Foram sete sujeitos entrevistados: filhos que cuidaram de seus pais, em estágio avançado de doença, cuidado estendido até o falecimento destes em suas respectivas residências. A experiência vivenciada foi relatada com o intuito de se entender como se dá o processo de construção do papel social de cuidador familiar e a desconstrução do mesmo mediante o falecimento do paciente, tendo a espiritualidade como fator de fortalecimento, a morte como pano de fundo e como demarcador da transição entre os processos.
Armenians on the Via Francigena: Armenian and Latin Sources on the Origins of the Armenian Community of Orvieto (Urbs Vetus)
Authors: Pambakian Stephanie , Zanetti Domingues Lidia
Published: October 2020

An Armenian religious community settled in Orvieto in the 13th century and founded the church and hospice of Santo Spirito, where they provided hospitality to pilgrims on the Via Francigena. Archaeological traces of their presence include a travertine gate with a trilingual inscription, reused in the church of San Domenico (Orvieto), the remains of the church of Santo Spirito, and art pieces removed from the latter. Contemporary Latin documents and an analysis of the historical context suggest that the Armenian presence was well-received by the lay and clerical authorities, and even held as prestigious.