bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluación del bienestar emocional como precursor del rendimiento académico
Authors: Taboada Russo Regina
Published: September 2022

En el siguiente artículo se analiza la necesidad de evaluar a los niños y adolescentes desde la etapa más temprana en cuanto a trastornos emocionales y de conducta, cómo estos han ido en aumento sobre todo a raíz de la pandemia y de qué manera pueden influir en el rendimiento académico. También se analiza un instrumento en concreto, SENA, para abarcar la evaluación de esta sintomatología.
Aula AUNOVA como entorno creativo en Educación Infantil y Primaria
Authors: Ciprián Pino Zahira , Gómez Serradilla María del Mar
Published: September 2022

El 5 de febrero de 2019 inauguramos este espacio innovador planteándolo como un espacio vivo y en construcción, con el propósito de que facilitara la atención a la diversidad, estimulara la creatividad y potenciara las múltiples inteligencias y habilidades de nuestro alumnado. AUNOVA es un sueño cumplido con el que logramos fomentar la motivación del alumnado por el aprendizaje y mejorar su autoestima.
The Potentials of Cabbage Phyllospheric Bacteria as Biocontrol Agents of Soft Rot Disease Caused by Pectobacterium carotovorum on Chinese Cabbage
Authors: Af’idzatuttama  , Nawangsih Abdjad Asih , Mutaqin Kikin Hamzah
Published: September 2022

Busuk lunak yang disebabkan oleh Pectobacterium carotovorum (Syn. Erwinia carotovora subsp. carotovora) merupakan salah satu penyakit penting pada tanaman sawi putih. Bakteri ini menghasilkan enzim pektinase yang dapat menguraikan pektin pada dinding sel tanaman bagian lamela tengah. Salah satu alternatif pengendalian penyakit busuk lunak ialah menggunakan agens biokontrol dari filosfer. Penelitian ini bertujuan menyeleksi dan menguji bakteri filosfer dari daun kubis yang berpotensi menghambat penyakit busuk lunak P. carotovorum pada sawi putih. Bakteri filosfer diisolasi dari wilayah Cianjur, Tegal, dan Bogor. Bakteri filosfer diuji keamanan hayati berdasarkan pada reaksi hipersensitivitas dan kemampuan lisis pada agar-agar darah, serta diuji kemampuan penghambatannya terhadap P. carotovorum berdasarkan pada uji antagonis secara in vitro dan uji penghambatan penyakit secara in vivo. Bakteri filosfer dikarakterisasi berdasarkan pada morfologi koloni dan sifat Gram. Dua galur bakteri filosfer paling berpotensi mengendalikan penyakit busuk lunak pada sawi putih diidentifikasi sebagai Chryseobacterium sp.
DNA Probe as Biosensor Candidate for Clavibacter michiganensis subsp. michiganensis on Tomato Plants
Authors: Hidayati Muslihah Nur , Suranto  , Susilowati Ari
Published: September 2022

The study was conducted to evaluate gene detection technique using a specific DNA probe to detect tomA gene in Clavibacter michiganensis subsp. michiganensis, a bacteria causing cancer in tomatoes. The probe was designed using Primer3Plus program, labeled with the non-radioactive molecule digoxigenin (DIG) and used in the hybridization method with the dot blot technique. The test samples consisted of two types, i.e. genomic DNA samples from pure bacterial cultures and from artificially infected tomato seeds with C. michiganensis subsp. michiganensis. Samples derived from pure bacterial cultures showed positive hybridization results at all levels of DNA concentration; while samples from tomato seeds only showed positive reactions at concentrations of 10, 8, 6, and 4 g L-1. This study concludes that the designed probe has the potential to be used in the development of biosensor-based detection methods for C. michiganensis subsp. michiganensis in tomato seeds and is quite specific because there is no cross-reaction with non-target bacterial groups.
Debt Management and Economic Development: Evidence from Nigeria
Authors: Ofurum Clifford Obiyo , Egbe Solomon , Sawyer Morris Ebikeniye
Published: September 2022

The study examined Nigeria's public debt management and economic development. Specifically, the study aims to establish a nexus between domestic debt management and two dimensions of economic development, the human development index and foreign currency reserve. The study adopted positivism as a philosophical basis and used time series data from 1981 to 2021. This study employs the Autoregressive Distributive Lag (ARDL) model, and E-view were used for analyses. The result did not reveal a meaningful relationship between domestic debt management and economic development. The study concludes that the large variability in economic development observed in Nigeria can only be related to the combined effects of the public debt management variables and not their individual effects. The study recommends that the government ensure that it operates a productive rather than a consumer economy, moderate external borrowing, and create an environment conducive to foreign investment.
Effects and dose-response relationship of exercise training on cardiometabolic risk factors in children with obesity
Authors: Liu Jingxin , Zhu Lin , Chen Zekai , Liao Jing , Liu Xiaoguang
Published: September 2022

Objectives

To explore the dose-response relationship between physical activity and the improvement of cardiometabolic risks in children with obesity, and provide a reference for the recommendation of physical activity for obese children.

Methods

A total of 96 children with obesity were recruited to participate in an exercise intervention program. An ActiGraph GT3X+ three-axis accelerometer was used to measure their physical activity. The dose groups (Q1∼Q4) were divided based on the quartiles of physical activity. The analysis of variance was used to compare the changes in body composition and cardiometabolic risk factors before and after the intervention.

Results

All intervention groups showed a significant reduction in weight, body mass index, body fat percent, fat mass, fat free mass, and skeletal muscle mass (p<0.01), and the change in the Q4 and Q3 groups was greater than in the Q2 and Q1 groups. Triglyceride, total cholesterol, low-density lipoprotein cholesterol, systolic blood pressure (SBP), and diastolic blood pressure (DBP) were significantly reduced after intervention in all groups (p<0.01), and the change in SBP, and DBP in the Q4 group was higher than in the Q1 group (p<0.05).

Conclusions

Exercise interventions could effectively improve body composition and cardiometabolic risk factors. A higher exercise dose is associated with significant improvements in body composition, and cardiometabolic health.
Segmentation of gastronomic consumers following Instagram influencers based on destination preferences and the effect of Covid-19 on their consumption
Authors: Szakály Orsolya
Published: September 2022

THE AIM OF THE PAPER

The aim of the study is to explore the impact of gastronomic influencers on Instagram on consumer decision before choosing a restaurant. It also examines the role of the characteristics of destination in consumer decision-making process. The article also highlights the impact of the Covid-19 Pandemic and its impact on consumers’ decision process in that context.

METHODOLOGY

In order to analyze the main research questions, a quantative survey with 329 valid responses was implemented and descriptive statistics, relationship analysis methods and linear regression were used to answer the research questions. The research question also required the use of a subsample (n=185) in which respondents who are willing to travel for gastronomic purposes were examined during the Pandemic.

MOST IMPORTANT RESULTS

According to the results, the collection of information from gastronomic influencers on the Instagram interface is popular among the respondents, and the influencers’ activity has a positive effect on the number of visitors to the destinations. Thus, it can be said that the relationship between the influencer and the destination is characterized by a significant, medium strength relationship. Furthermore, the results also revealed that the Pandemic has led to an increase in consumers’ intentions to consume in restaurants.

RECOMMENDATIONS

As social media plays an increasingly important role in the decision-making process, it is important that professionals, service providers and researchers explore the views of consumers in the context under study. The results are highlighted in terms of destination development and in terms of consumer behavior.
Az imposztor szindróma munkaerő-piaci relevanciája
Authors: Ásványi Zsófia , Barakonyi Eszter , Riedelmayer Bernadett
Published: September 2022

A TANULMÁNY CÉLJA

A pszichológiában az imposztor szindróma egy kognitív torzulás, mely megakadályozza, hogy az egyén megélje a munkateljesítményéhez kapcsolódó sikerélményt. Az állapotot először 1978-ban azonosították Paulin Rose Clance és Suzanne Imes pszichológusok, akik kezdetben úgy gondolták, hogy ez főként egy nőket érintő jelenség. A későbbiekben végzett kutatások eredménye szerint viszont az imposztor-szindróma a munkavállalók mintegy 70 százalékát érinti a pályafutása során. Tanulmányunkban arra keressük a választ, hogy a jelenség a megkérdezett munkavállalók körében mennyire elterjedt, kiket érint és nem utolsó sorban, hogy milyen hatással van az egyén munkateljesítményére, előmenetelére. Szintén fontos célkitűzése a kutatásnak, hogy felmérjük mennyire hátráltató, vagy éppenséggel motiváló a szindróma hatása az egyéni munkateljesítményre.

ALKALMAZOTT MÓDSZERTAN

Kutatásunk alapját egy 2022. márciusban végzett kérdőíves felmérés adta, amelyet magyar munkavállalók körében végeztünk. A kérdőívben megvizsgáltuk az imposztor szindróma nem, életkor és végzettségi szint alapján történő előfordulását a kitöltők körében. A kutatásban továbbá azt is felmértük, hogy ha a jelenség egy korábbi életszakaszban jelentkezett, akkor hány évesen, illetve hány év munkatapasztalatot követően múlt el, valamint, hogy a tapasztalt jelenség miként hatott az egyén munkateljesítményére. Az adatokat kereszttábla elemzéssel és statisztikai vizsgálatokkal értékeltük.

LEGFONTOSABB EREDMÉNYEK

Összesített eredményeink alapján megállapíthatjuk, hogy az imposztor szindróma a kutatásunkban résztvevő alanyok 86,4%-a esetében jelenleg is fennáll és mindössze 13,6%-uk érzi úgy, hogy megszűnt bizonyos kor elérése és szakmai tapasztalat megszerzését követően. A jelenség a mintában elsősorban felsősokú végzettséggel rendelkező nőket érinti, amely állandósult, jelenleg is fennálló belső szorongás érzését jelenti számukra. A szindróma intenzitása az életkor előre haladtával (és ezzel párhuzamosan a munkapasztalat növekedésével) csökkenhet és enyhe, mérsékelt hatást mutathat. A teljes mintában a tünetegyüttes alapvetően ösztönzőleg hat a teljesítményre és az életkor növekedésével csökken a jelenség teljesítményre gyakorolt blokkoló hatása.

GYAKORLATI JAVASLATOK

A kutatás eredményei hozzájárulhatnak az imposztor szindróma hazai előfordulásának részletesebb megismeréséhez, annak munkateljesítményre gyakorolt hatásának megértéséhez. További kutatási irányként a jövőben érdemes volna a mintaelemszámot növelve ágazat-, földrajzi/településnagyság, vezetői/nem vezetői munkakör specifikumokat meghatározni, valamint a pályájuk elején álló fiatal (25 év alatti) munkavállalók körében nagyobb számban megvizsgálni a jelenség előfordulásának jellemzőit.
The Movement of the Local Noble Family in Nonsan Region and the Establishment of Seowon(書院) during the Joseon Dynasty
Authors:   Institute of Korean Cultural Studies Yeungnam University, Lee Yeon Suk
Published: September 2022

After returning home, the local elites in Nonsan region formed a close relationship with each other through academic lineage and marital lineage, and grew into dominant families by exchanging mainly through Seojae, Seowon, and Hyang-gyo. In addition, due to their voluntary military activity and altruistic death, they were respect in the local community, which led to the establishment of Seowon and incense for them.
The figures incensed at Eunjinhyeon Seowon are those of rigid determination, s uch a s l oyal s ervants a nd d utif ul c hildren, a nd t he figures incensed at Donam Seowon and Nogang Seowon, which are representative Seowons of Yeonsan-hyeon and Noseong-hyeon, respectively, are those of the Taoistic origins of Noron and Soron. The reputation of figures incensed at an Seowon was directly related to honor of that Seowon. Accordingly, Donam Seowon represented Noron-family one, while Nogang Seowon represented Soron-family Seowon.
The Gwangsan Kim's family in Yeonsan and Papyung Yun's family in Noseong, the representative local elites of the Nonsan region, lived close to each other and served mainly as public officials. They maintained the position o f the W est faction in t he p rocess of East-West p olitical separation and returned home during the Manchu war, after which, maintained a close relationship through academic, bloody, and geographic lineages while maintaining a family and building a geographic foundation through teaching activities. However, after the Noron-Soron Divergence, the cooperative relationship between these two families and between Donam Seowon and Nogang Seowon turned into a conflicting relationship. Yoensan and Noseong, therefor, seems to have been a kind of miniature that reflected the central political situation as it is at that time.
A Study on the Characteristics of Lee Ju-cheon’s Yijing Thought
Authors:   Institute of Korean Cultural Studies Yeungnam University, Yi Suhn-Gyohng
Published: September 2022

This paper studied the characteristics of Lee Ju-cheon's thoughts through his writings. Lee Ju-cheon is a scholar of the Namin line, and his specific academic background is unknown. The content of his work is mainly related to Yijing, so it shows the core of his idea. Among his writings, Sinjeunghwang-geugnaepyeon can be cited as one of the representative studies on Hongbeomhwang-geugnaepyeon in Joseon. He made up for the shortcomings of existing research and made his own new attempts. He argued that mathematical principles and human values should be combined.
He wrote under the title "Yielding[柔] is better than Firming[剛]" and he discussed the value of "Yielding" from a Confucian perspective, not from a Taoist perspective. He paid attention to the value of the Way of Earth and Yielding rather than to the Way of of Heaven and firm. It shows an aspect of the change in the ideological world in the late Joseon Dynasty.
The core thought of the philosophy of Mozi is UY
Authors:   Institute of Korean Cultural Studies Yeungnam University, Park jin woo
Published: September 2022

This thesis attempts to examine the core thought of the philosophy of Mozi, which received sympathy from the people along with Confucianism, during the age of Warring States period of the 5th to 3rd centuries B.C.
Each Scholars argue differently about what the core thought of Mozi philosophy is. In general, Mencius accepts 'Mozi is Gyeom-ae (兼爱)' which is what Mencius said while criticizing the philosophy of Mozi, and insists that the central thought of the philosophy of Mozi is Gyeom-ae (兼愛).
However, in this thesis, I would like to emphasize that the core of the Mozi philosophy is 'Uy(義)' derived from ‘Heaven's will(天志)’.
And then. Through Mozi's by side 'Heaven's will(天志)･legal way(法儀)･ valuable Uy(貴義), Gyeom-ae(兼愛)', I want to find the source of the thought that Mozi centered on. Mozi is looking from heaven(天)for the source of the direction in which the most persecuted people in the turbid world should live, called the age of Warring States period.
'What heaven(天) wants is a righteous world where people live and help each other equally.' and at the same time, he said. it is called 'nothing else on earth is more precious than the righteousness' and Among them 'the Uy(義)' is the most valuable value. It is emphasized that people should use 'the Uy(義)' as the standard of value in life and continue to do a righteous acts. If scholars act righteously, they contribute to society by leaving much more profit than the merchants in the face of difficulties.
As such, people insist on serving the will of heaven, 'The Uy(義)', and practicing the spirit of 'serving' and 'sharing' to share with the world.
In Mozi, ' The Uy(義)' is a dual concept, meaning 'the right thing(正)' and 'correcting(政)' in side 'legal way(法儀)'.
In other words, 'Uy(義)' has a dual meaning, which means moral role as 'right thing(正)' and political role as 'correcting(政)' and it is said that it has both the moral concept of right and the concept of punishment to be observed.
It is in the same context as the doctrine of Gyeom-ae(兼愛) that the Uy(義) of Mozi is the spirit of "serving" and "sharing." The Doctrine of Gyeom-ae(兼愛) in Mozi’s is a means and a way to a righteous society.
In the end, Mozi's doctrine of Gyeom-ae(兼愛) is a shortcut to practicing righteousness and a way out of a difficult environment for people's lives.
Gyeom-ae(兼愛) is a very important concept in the philosophy of Mozi, but it is a means to practice the Uy(義). Conclusionally, I will say that the core of Mozi's philosophy is ‘‘Heaven’s Will(天志) is the Uy(義).’
Dying Dreams in Tajikistan’s Global Borderland
Authors: Mostowlansky Till
Published: September 2022

Twenty-five years since the end of Tajikistan’s civil war in 1997, dreams and aspirations of international development and cross-border mobility in the country’s Gorno-Badakhshan Autonomous Province, colloquially called “the Pamirs,” have evaporated. Once the mountainous region was envisaged to have a prosperous postwar future ahead of it, with emerging trade links to China and Afghanistan, substantial funding from international nongovernmental organizations, and support from wealthy Muslim institutions. Today, as the Tajik government mounts a violent campaign to eradicate opposition, people in the Pamirs are surrounded by closed international borders and an ever-shrinking space in which to participate in Tajikistan’s politics and economy.
A conserved signaling pathway activates bacterial CBASS immune signaling in response to DNA damage
Authors: Lau Rebecca K , Enustun Eray , Gu Yajie , Nguyen Justin V , Corbett Kevin D
Published: September 2022

To protect themselves from the constant threat of bacteriophage (phage) infection, bacteria have evolved diverse immune systems including restriction‐modification, CRISPR‐Cas, and many others. Here, we describe the discovery of a two‐protein transcriptional regulator module associated with hundreds of CBASS immune systems and demonstrate that this module drives the expression of its associated CBASS system in response to DNA damage. We show that the helix‐turn‐helix transcriptional repressor CapH binds the promoter region of its associated CBASS system to repress transcription until it is cleaved by the metallopeptidase CapP. CapP is activated in vitro by single‐stranded DNA, and in cells by DNA‐damaging drugs. Together, CapH and CapP drive increased expression of their associated CBASS system in response to DNA damage. We identify CapH‐ and CapP‐related proteins associated with diverse known and putative bacterial immune systems including DISARM and Pycsar antiphage operons. Overall, our data highlight a mechanism by which bacterial immune systems can sense and respond to a universal signal of cell stress, potentially enabling multiple immune systems to mount a coordinated defensive response against an invading pathogen.
Türkiye’de cinsiyete dayalı işsizlik histerisinin analizi
Authors: AZAZİ Hasan
Published: September 2022

İşsizlik histerisi ekonomik dalgalanma neticesinde işsizlik oranının artması ve dalgalanma geçtikten sonra eski seviyesine inmemesi durumudur. İşsizlik histerisinin bulunması işgücü piyasası açısından olumlu bir durum değildir. İşgücü piyasasında işsizlik histerisi bulunması, piyasaya düzenleyici müdahaleyi gerekli kılmaktadır. Çalışmada Türkiye’de cinsiyete dayalı işsizlik histerisinin araştırılması için Ocak 2005 ve Mayıs 2022 dönemi kadın ve erkek işsizlik oranları kullanılmıştır. İşsizlik histerisinin araştırılması için ise Genelleştirilmiş Dickey-Fuller Birim Kök Testi, Fourier Genelleştirilmiş Dickey-Fuller Birim Kök Testi ve Phillips Perron Birim Kök Testi kullanılmıştır. Birim kök testlerinden elde edilen sonuçlar, Türkiye’de erkeklerin kadınlardan daha fazla işsizlik histerisi etkisi barındırdığını göstermektedir. Dolayısıyla işgücü piyasalarına yapılacak düzenlemelerde bu durumun göz önünde bulundurulması önerilmektedir.
Why Do so Few People with Heart Failure Receive Cardiac Rehabilitation?
Authors: Thompson David R , Ski Chantal F , Clark Alexander M , Dalal Hasnain M , Taylor Rodney S
Published: September 2022

Many people with heart failure do not receive cardiac rehabilitation despite a strong evidence base attesting to its effectiveness, and national and international guideline recommendations. A more holistic approach to heart failure rehabilitation is proposed as an alternative to the predominant focus on exercise, emphasising the important role of education and psychosocial support, and acknowledging that this depends on patient need, choice and preference. An individualised, needs-led approach, exploiting the latest digital technologies when appropriate, may help fill existing gaps, improve access, uptake and completion, and ensure optimal health and wellbeing for people with heart failure and their families. Exercise, education, lifestyle change and psychosocial support should, as core elements, unless contraindicated due to medical reasons, be offered routinely to people with heart failure, but tailored to individual circumstances, such as with regard to age and frailty, and possibly for recipients of cardiac implantable electronic devices or left ventricular assist devices.
Imaging in Women with Heart Failure: Sex-specific Characteristics and Current Challenges
Authors: Leo Isabella , Nakou Eleni , de Marvao Antonio , Wong Joyce , Bucciarelli-Ducci Chiara
Published: September 2022

Cardiovascular disease (CVD) represents a significant threat to women’s health. Heart failure (HF) is one CVD that still has an increasing incidence and about half of all cases involve women. HF is characterised by strong sex-specific features in aetiology, clinical manifestation and outcomes. Women are more likely to have hypertensive heart disease and HF with preserved ejection fraction, they experience worse quality of life but have a better overall survival rate. Women’s hearts also have unique morphological characteristics that should be considered during cardiovascular assessment. It is important to understand and highlight these sex-specific features to be able to provide a tailored diagnostic approach and therapeutic management. The aim of this article is to review these aspects together with the challenges and the unique characteristics of different imaging modalities used for the diagnosis and follow-up of women with HF.
Optimización del “Germinator” como complemento de análisis de calidad germinativa de semillas de arroz (Oryza sativa L.)
Authors: Barboza-Barquero Luis Orlando , Hernández-Pridybailo Andrés , Vargas-Ramírez Ester , Zerpa-Catanho Dessireé , Vega-López Marialicia , Zúñiga-Centeno Adonay
Published: September 2022

Introducción. El uso de análisis de imágenes digitales con el “Germinator” permite evaluar la germinación de las semillas de forma automática. Además de la germinación máxima, se pueden cuantificar otros parámetros asociados al vigor de forma simultánea. Objetivo. Optimizar el “Germinator” como complemento de análisis automático de calidad germinativa de semillas de arroz. Materiales y métodos. Los experimentos se realizaron en el Centro para Investigaciones en Granos y Semillas (CIGRAS) durante el 2015 al 2018. Se optimizó el paquete de software denominado “Germinator” en la variedad Palmar 18 y después se probó con un panel de 126 muestras de semillas de arroz compuesta por catorce variedades. Se cuantificaron curvas de germinación, los datos obtenidos de forma automática se compararon con conteos manuales de protrusión radicular y con una metodología estandarizada. Además, se realizaron experimentos de envejecimiento acelerado y envejecimiento controlado para mostrar la sensibilidad del método automatizado. Resultados. La relación entre la germinación obtenida de forma automática y la cuantificada de forma manual fue alta (R2= 0,99). La germinación máxima, cuantificada por medio del análisis de imágenes varió de 69 % a 100 % en el panel de 126 muestras. La correlación entre la germinación evaluada mediante imágenes digitales y el método estándar fue de rho (spearman)= 0,34. El “Germinator” permitió cuantificar de forma simultánea otras variables asociadas con el vigor de las semillas, como el parámetro t50, que es el tiempo que la muestra de semillas toma para alcanzar el 50 % de la germinación. Además, el método automático reveló el efecto diferenciado de dos protocolos de envejecimiento. Conclusiones. El uso de análisis de imágenes en arroz permitió evaluar la germinación de forma automática basado en la protrusión radicular y también posibilitó cuantificar otras variables complementarias asociadas al vigor de la semilla (t50).
Algebra of Data Reconciliation
Authors: Csirmaz Elod P. , Csirmaz Laszlo
Published: September 2022

With distributed computing and mobile applications becoming ever more prevalent, synchronizing diverging replicas of the same data is a common problem. Reconciliation – bringing two replicas of the same data structure as close as possible without overriding local changes – is investigated in an algebraic model. Our approach is to consider two sequences of simple commands that describe the changes in the replicas compared to the original structure, and then determine the maximal subsequences of each that can be propagated to the other. The proposed command set is shown to be functionally complete, and an update detection algorithm is presented which produces a command sequence transforming the original data structure into the replica while traversing both simultaneously. Syntactical characterization is provided in terms of a rewriting system for semantically equivalent command sequences. Algebraic properties of sequence pairs that are applicable to the same data structure are investigated. Based on these results the reconciliation problem is shown to have a unique maximal solution. In addition, syntactical properties of the maximal solution allow for an efficient algorithm that produces it.
Question of searching for indicators of morbiditi in pregnant women with the uterine scar due to cesarean section
Authors:   Ivano-Frankivsk National Medical University, Ukraine, Rymarchuk M.I.
Published: September 2022

Despite a continuous improvement of obstetric care, progressive usage of the latest instrumental and functional methods of diagnosis, treatment and prevention, the number of normal deliveries reduced to 10–20%. This is due to a continuous increase in the incidence of extragenital diseases and various pathologies inwomen during pregnancy. There were analyzed 250 caesarean sections. In women with a scar on the uterus, the increased number of extragenital diseases was found. In general, the cases of extragenital pathology were diagnosed 1.8 times more often as compared to obstetric one. Obstetricpathology, thatoccurs on the background of other exacerbatedsomatic diseases, negatively impacts clinical and perinatal outcomes. Key words: сesarean section, somatic and obstetric morbidity.
Medicated liver damage during pregnancy
Authors:   Shupyk National Medical Academy of Postgraduate Education, Kiev, Gopchuk E.N.
Published: September 2022

The significant frequency of drug-related liver damage during pregnancy, the lack of unified approaches to forecasting issues, the standards for diagnosis and drug correction, as well as the underestimation of the risk of disease for pregnancy outcomes characterize this problem as highly relevant and significant for modern obstetrics. Any drugs in a pregnant woman can cause drug hepatitis, so all of them should be prescribed to pregnant women only for strict clinical indications. In this case, one should take into account the genetic predisposition, history and risk factors for the development of the disease, avoid polypharmacy and adjust the dose and route of administration of the drugs used (especially hormonal ones) based on the state of the liver. If the liver indices deviate from the norm, careful monitoring of drug therapy with a monthly or more frequent determination of the level of serum transaminases, alkaline phosphatase, gamma-glutamyl transpeptidase and bilirubin is necessary. The tactics of managing pregnant women with drug-induced hepatitis requires high medical responsibility when deciding whether to prolong the pregnancy or to terminate it, on the possibility of breastfeeding, determining the type of delivery, anesthetic management and managing the patient in the postpartum period. Key words: drug-induced liver damage, hepatotoxicity, pregnant cholestatic hepatosis, acute fatty hepatosis, HELLP-syndrome, estrogens, progestogens, sublingual progesterone, parenteral progesterone, hepatoprotectors.
Modern principles of treatment of perinatal infections
Authors:   Kharkov Medical Academy of Postgraduate Education, Grishchenko O.V. , Bobrytska V.V. ,   Kharkiv National University named after V.N. Karazin
Published: September 2022

The objective: was to optimize the treatment of perinatal infections and improve perinatal outcomes by using macrolide with a wide spectrum of action of Doramycin (spiramycin). Materials and methods. A retrospective analysis of data and dynamic observation of 130 pregnant women with positive results of infectological studies was carried out. I (main) group of 50 patients receiving Doramycin 3 mln 3 times a day for 10 days; II (comparison group) 40 patients receiving pulse therapy with azithromycin 1 g per day on the 1st, 7th, 14th day, III (control group) 40 patients who did not receive antibiotic therapy. The selection criteria for pregnant women for this observation were the positive results of ELISA, PCR, bacteriological studies in combination with the pathological course of the perinatal period, clinical and ultrasonographic data. Results. Elimination of chlamydial infection, toxoplasma, pathogenic flora sensitive to macrolides was observed mainly in patients of group I treated with Doramycin. Perinatal outcomes were also significantly better among patients in the main group. In group III, which did not receive antibiotic therapy, there was a high percentage of small children, premature birth and neonatal morbidity. Conclusion. Doramycin is an effective and safe drug, the use of which can be recommended during pregnancy, complicated by perinatal infections. The use of Doramycin significantly improves the outcome of labor for the mother and fetus. Key words: doramycin, spiramycin, perinatal infections, treatment.
Pyroptosis in NLRP3 inflammasome-related atherosclerosis
Authors: Zeng Xiang , Liu Dongling , Huo Xia , Wu Yue , Liu Cuiqing , Sun Qinghua
Published: September 2022

Pyroptosis is a proinflammatory form of programmed cell death in response to inﬂammation. It involves in the pathogenesis and outcomes of atherosclerosis characterized by NLRP3 inflammasome assembly, membrane pore formation, cell swelling, pro-inflammatory mediator and cytokine release. There are known pyroptosis molecular pathways including the caspase-1 depended canonical signaling pathway and the caspase-4/5/11 determined non-canonical signaling pathway. It is essential to explore the connection among NLRP3 inflammasome, pyroptosis and atherosclerosis, which may shed light on the potential therapeutic strategies that target pyroptosis in atherosclerotic treatment.
Occurrence and potential mechanism of holin-mediated non-lytic protein translocation in bacteria
Authors: Brüser Thomas , Mehner-Breitfeld Denise
Published: September 2022

Holins are generally believed to generate large membrane lesions that permit the passage of endolysins across the cytoplasmic membrane of prokaryotes, ultimately resulting in cell wall degradation and cell lysis. However, there are more and more examples known for non-lytic holin-dependent secretion of proteins by bacteria, indicating that holins somehow can transport proteins without causing large membrane lesions. Phage-derived holins can be used for a non-lytic endolysin translocation to permeabilize the cell wall for the passage of secreted proteins. In addition, clostridia, which do not possess the Tat pathway for transport of folded proteins, most likely employ non-lytic holin-mediated transport also for secretion of toxins and bacterioc-ins that are incompatible with the general Sec pathway. The mechanism for non-lytic holin-mediated transport is unknown, but the recent finding that the small holin TpeE mediates a non-lytic toxin secretion in Clostridium perfringens opened new perspec-tives. TpeE contains only one short transmembrane helix that is followed by an amphipathic helix, which is reminiscent of TatA, the membrane-permeabilizing component of the Tat translocon for folded proteins. Here we review the known cases of non-lytic holin-mediated transport and then focus on the structural and functional comparison of TatA and TpeE, resulting in a mechanistic model for holin-mediated transport. This model is strongly supported by a so far not recognized naturally occurring holin-endolysin fusion protein.
Trabzon, Kaymaklı Manastırı Katholikonu Duvar Resimleri
Authors: SOYKAN A. Nazlı
Published: September 2022

Trabzon yüzyıllar boyunca başta Rumlar, Ermeniler ve Müslümanlar olmak üzere birçok etnik gruba ev sahipliği yapmıştır. IV. Haçlı Seferi nedeniyle parçalanan Bizans İmparatorluğu çeşitli bölgelerde küçük beylikler/imparatorluklar kurmuştur. Bunlardan biri de 1204 yılında kurulan Trabzon Rum İmparatorluğu’dur. Özellikle 1204 yılında Trabzon Rum İmparatorluğu’nun kurulmasından 1261 yılında yıkılmasına kadar bölgedeki inşa faaliyetleri fazlalaşmış, var olan yapıların da onarımları sağlanmıştır. Komnenos sülalesinin başta olduğu bu dönem yapılarında, özellikle de manastırlarda farklı dönemlerde eklemeler yapıldığı görülmektedir. Yapılarda farklı zaman dilimlerinde farklı ustaların çalışmaları hem Konstantinopolis hem de bölgedeki yerel geleneklerin bir arada olmasına olanak sağlamıştır. Bu etkilerin görüldüğü yapılardan biri de Kaymaklı Manastırı’dır. Kaymaklı Manastırı katholikonu duvar resimlerinde Ermeni gelenekleriyle Rum gelenekleri birarada kullanılmıştır. Ermenilerin bölgeye hangi tarihte, nasıl geldiklerine dair net bir bilgi bulunmamaktadır. 1400 yılında Timur’un Sebasteia’yı neredeyse tamamen yağmalamasıyla Ermenilerin Trabzon’a kaçtığı bilinmektedir. Bu tarihten sonra da Trabzon’da Ermeni nüfusunun ve yapılaşmasının arttığı görülmeye başlanmıştır. Çalışmanın konusu Trabzon’un 3 km güneybatısında, Çukurçayır Mahallesinde, Mithra (Boztepe) Dağı’nın doğu yamaçlarında yer alan Kaymaklı Manastırı Katholikonu duvar resimleridir. Tek nefli bazilikal planlı olan yapı 1923 yılında gerçekleşen Lozan Mübadelesi’ne kadar işlevini sürdürmüş, zorunlu göç sebebiyle bu dönemden sonra terk edilmiştir. Ermeni yapısı olan manastır hakkında yapılan çalışmalar oldukça sınırlıdır. Katholikonun duvar resimleriyle ilgili çalışmalar ise neredeyse yok denilecek kadar azdır. Duvar resimleriyle ilgili yapılan çalışmalarda sahne isim ve detayları verilmemiş, duvar resimlerinden genel olarak bahsedilmiştir. Bu çalışmada katholikonun duvar resimlerinin ilk defa aletli ölçülü çizimleri yapılmış, ikonografilerine değinilmiş ve hem bölge içinde hem de bölge dışındaki benzer örnekleriyle karşılaştırmalı olarak değerlendirilmiştir.
Information and communication technologies in contextual target situation analysis: improving Online CEAP course design in developing countries
Authors: Vieira Bruna Gabriela Augusto Marçal
Published: September 2022

This paper discusses the benefits of information and communication technologies (ICT) in the contextual target situation analysis at a distance to design online critical English for academic purposes (CEAP) courses. A contextual investigation of the publishing process of high-impact journals in computer science is presented, which is aimed at identifying issues that might influence the publication of Brazilian researchers’ papers. The beliefs and experiences of Brazilian authors in the aforementioned process were analyzed through electronic questionnaires and remote interviews. Moreover, research articles’ reviews were studied to identify the community´s criteria for accepting or rejecting papers. Via ICT, a wider contextual analysis was possible with participants located in different parts of the world. Results provided relevant information about researching and publishing in the field, which may substantiate the design of tasks aimed at improving students’ critical academic literacy. For developing continental countries such as Brazil, saving time and resources through ICT in CEAP courses’ design means the possibility of investing in a more relevant instruction, which better attends to students’ contextual needs and wants.
CLINICAL AND EPIDEMIOLOGICAL EVALUATION OF COMPLICATIONS ASSOCIATED WITH GALLSTONES IN A TERTIARY HOSPITAL
Authors: AGUIAR Ridson Guilherme Parente de , SOUZA JÚNIOR Francisco Emanoel Albuquerque de , ROCHA JÚNIOR José Leonardo Gomes , PESSOA Francisco Sérgio Rangel de Paula , SILVA Leidiane Pinho da , CARMO Gardênia Costa do
Published: September 2022

ABSTRACT Background: Gallstones are the presence of bile clay in the gallbladder or bile ducts. The disease can be asymptomatic or symptomatic and can lead to complications and consequently a worse prognosis, such as acute cholecystitis, choledocholithiasis, cholangitis, and acute pancreatitis. The risk of complications increases after the first episode of biliary colic. Objective: A clinical-epidemiological evaluation of patients admitted to a gastroenterology ward of a tertiary care hospital with gallstone-related complications. Methods: We evaluated 158 patients admitted through discharge reports and medical records analysis from January 1, 2013, to February 24, 2021. Results: The female sex was predominant (76.6%), and the mean age of patients was 51.6 years. Men were significantly older than women (P=0.005). Most (57.6%) had some comorbidity, the most frequent being systemic arterial hypertension, diabetes mellitus, and obesity. The mean hospitalization time was 24 days, significantly longer in men (P=0.046) but without a direct relationship with age (P=0.414). The most frequent complication was choledocholithiasis, and 55.7% of patients without previous cholecystectomy had a report of biliary colic before admission, on average 1.5 years previously. A history of a prior cholecystectomy was present in 17.1% of those evaluated. Abdominal ultrasonography followed by magnetic resonance cholangiography was the most frequently performed exam for diagnostic definition. Regarding therapeutic measures, endoscopic retrograde cholangiopancreatography was necessary for 47.3% of patients without previous cholecystectomy and 81.4% of patients who have already had a cholecystectomy. Among patients not yet cholecystectomized, 84% underwent the procedure before discharge. Conclusion: The female patients were predominant. Men were significantly older than women and had more extended hospital stays. The most frequent complication was choledocholithiasis, and around half of the patients reported previous biliary colic. endoscopic retrograde cholangiopancreatography has been necessary for the majority of the patients.
Predicting optimal dispersant (superplasticiser) content for cement–limestone pastes from rheological tests
Authors: Damineli Bruno Luís , John Vanderley Moacyr , Pileggi Rafael Giuliano
Published: September 2022

Currently, one of the most important trends in concrete technology is the use of inert fine particles (fillers) to decrease cement content, increase packing in the paste and increase flowability, with gains in technological, environmental and cost aspects. The advance in dispersion technology (using superplasticisers) is one of the technical issues that allows pastes to be mixed without the expected increase of water content – which decreases compressive strength – caused by the filler's high surface area. However, the use of no more than the optimal dispersant (superplasticiser) content (lowest content that provides the lowest viscosity) is crucial owing to cost constraints. This paper evaluates the possibility of predicting optimal dispersant content in cement–limestone filler systems from the optimal dispersant content previously measured in the pure raw materials. Owing to the need for only a few sets of tests, this can optimise the design timing and accuracy of efficient pastes for lower binder concretes.
Optimal urban planning through the best–worst method: bicycle lanes in Palermo, Sicily
Authors: Campisi Tiziana , Moslem Sarbast , Al-Rashid Muhammad Ahmad , Tesoriere Giovanni
Published: September 2022

Since 2020, due to the Covid-19 pandemic, planners and designers have proposed numerous changes for urban spaces and mobility concepts to comply with governments’ anti-contamination restrictions. Several European cities have implemented strategies for developing cycling, favouring the design of temporary (pop-up) or permanent cycle lanes and state incentives to purchase bicycles and electric micro-mobility vehicles. However, existing research suggests that design optimisation must pursue specific geometric, functional and safety standards for cyclists and space sharers (pedestrians/cars). It is thus necessary to analyse the perceptions of citizens and commuters for optimisation of the planning and design of these infrastructures. A multi-criteria evaluation was used to determine optimal infrastructure schemes (temporary and permanent) for the metropolis of Palermo in Sicily, Italy. First, three groups of cyclists (citizens, technicians and commuters) were selected. Then, applying the best–worst method, a series of design alternatives were evaluated by the target groups. The results showed a correlation between different types of users in terms of those who live in the city compared with commuters in the city for the first time. The results of this work lay the foundation for improved planning and design strategies in sustainable urban mobility plans and the Italian Biciplan guidelines.
A hadijog és a hadifogság története az egészségügy szemszögéből
Authors: Óbert Mariann
Published: September 2022

Célom összefoglalni a hadijog fejlődésének főbb állomásait különös tekintettel a hadifogságegészségügyi vonatkozásaira, valamint a rendelkezésre álló irodalmi forrásokalapján jellemezni a hadifogolytáborok egészségügyi helyzetét az első és másodikvilágháború során. Végül megemlítek két magyar vonatkozású hadifogoly történetet.Az általam felhasznált források alapján elmondható, hogy a hadijog nemzetközi történetébena hadifoglyok védelmére mindig is volt törekvés, de a nagy tömeg, a végesegészségügyi és logisztikai források, valamint a gazdasági- és politikai körülményekellehetetlenítették a szabályzók betartását. A kialakult helyzet komoly, teljesíthetetlenkihívás elé állította az egészségügyi ellátást.
Multidomén műveletek városi környezetben
Authors: Mező András
Published: September 2022

A NATO jövő műveleteinek legvalószínűbb és legveszélyesebb környezete a városlesz. A városi környezet három réteget tartalmaz, a fizikai, az információs és a humánrendszert, amelyek jelentősen módosíthatják a formálódó multidomén műveletekelveit. A jövő többdimenziós NATO erői képesek lesznek megérteni a városi környezetetés gyorsan alkalmazkodni a konfliktushoz, folyamatosan összehangolni a doménközicsapásokat, és ezzel előnyt szereznek az ellenféllel szemben.
A mesterséges intelligencia katonai alkalmazásának hatása a demokráciákra
Authors: Négyesi Imre
Published: September 2022

Ebben a cikkben a mesterséges intelligencia alkalmazása, azon belül elsősorban katonaicélú felhasználása került összefoglalásra abból a szempontból, hogyan befolyásolhatjaaz a demokráciát. Miután a demokráciának többféle megjelenési típusát és megjelenésiformáját ismerjük, ezért ezt tekintjük a vizsgálat kiindulási pontjának. A cikk továbbifejezeteiben elemzésre került néhány amerikai DoD1 dokumentum, hogy képet kapjunkaz állam, a hadsereg és a demokrácia egymáshoz fűződő viszonyáról. Az elemzéssorán természetesen kiemelt figyelem fordul a katonai célú mesterséges intelligenciákra.
A háború áldozatai: a diszkriminációs szabály története és kortárs dilemmái
Authors: Boda Mihály , Rémai Dániel
Published: September 2022

A háborúkat a politikusok indítják, a katonák vívják, és az ártatlanok, civilek ésnemharcolók szenvedik. A katonai etika, és az igazságos háború elméletén belül folyógondolkodásnak ezért régóta fontos és összetett része ezeknek a csoportoknak avédelme, figyelembe véve a háború természetéből fakadó sajátosságokat is. Az ártatlanok,civilek és nemharcolók védelmét előíró szabály a diszkriminációs szabály, amineka történetével és tartalmával foglalkozik ez a tanulmány. Egy dolog azonban egy szabálytörténetének és tartalmának a felvázolása, komoly jelentősége van annak, mennyibenlehet betartani előírását, illetve, hogy a valóságban mennyiben tartják azokat.
Közvetlen és közvetett környezetből származó kihívások Magyarország biztonságpercepciója szempontjából – Szerbia, Ukrajna, Kenya, Etiópia, Uganda
Authors: Szászi Ivett
Published: September 2022

Magyarország biztonsági, külpolitikai, valamint nemzetközi fejlesztési stratégiái az ország közvetlenkörnyezetének vizsgálata alapján a Nyugat-Balkánon fennálló vallási radikalizmust, migrációt,kábítószer-kereskedelmet, a posztszovjet térségben a kiberfenyegetést, a gázellátás törékenységét,valamint mindkét térségben a határon túli magyarokat érő atrocitásokat jelölték meg a legnagyobbkihívásként. A közvetett környezetet vizsgálva a szubszaharai Afrika térségéből származó, azéghajlatváltozás, a népességnövekedés és a politikai válságok hatására erősödő migrációs nyomástazonosították kihívásként. Jelen tanulmány arra keresi a választ, hogy a közvetlen és közvetettkörnyezetből származó biztonsági kihívások miként alakítják Magyarország biztonságpercepcióját.
Socio-economic analysis of solar photovoltaic-based mini-grids in rural communities: A Ugandan case study
Authors: Cartland Richard , Sendegeya Al-Mas , Khan Hakizimana Jean de Dieu
Published: September 2022

The provision of electricity in rural areas has been an outstanding need in trying to achieve the United Nations sustainable development goals (SDGs) by 2030. However, most sub-Saharan countries have found this difficult due to financial constraints. Uganda tried to increase rural electrification to more than 20% of its population by 2020 through Rural Electrification Agency programmes. In an attempt to realise SDGs and the National Vision by 2040, Uganda is investing more in renewable energy sources, especially solar photovoltaic mini-grids to ensure that rural areas access affordable, reliable, and sustainable modern energy. This paper assesses the operation, causes of failure, causes of discomfort for mini-grid connected customers, and customer behavior of two solar photovoltaic mini-grids located in Kyenjojo District in western Uganda. It was found that the current energy demand exceeds the generation supply and that the systems need phase upgrades and clustering to remain economically viable and sustainable. The methodology involved re-sizing the existing load demand of the connected users, well-designed and administered questionnaires, analysis of published literature, review of the existing records, and interviews. Analysis was done in an Excel software program. The paper concludes by identifying the benefits and challenges of solar photovoltaic mini-grids in Kyenjojo District.