bluuebunny/crossref_metadata_2025 huggingface dataset:
The future of psychiatric research
Authors: Caldieraro Marco Antonio ,   Hospital de Clínicas de Porto Alegre,  Brazil,   Universidade Federal do Rio Grande do Sul,  Brazil
Published: January 2017

Abstract Psychiatric disorders place considerable burden on individuals and on public health. Funding for research in psychiatry is less than ideal, but even so high quality research is being conducted at many centers. However, these studies have not impacted clinical practice as much as expected. The complexity of psychiatric disorders is one of the reasons why we face difficulties in translating research results to patient care. New technologies and improved methodologies are now available and must be incorporated to deal with this complexity and to accelerate the translational process. I discuss the application of modern techniques for data acquisition and analysis and also the new possibilities for performing trials in virtual models of biological systems. Adoption of new technologies is necessary, but will not reduce the importance of some of the fundamentals of all psychiatry research, such as the developmental and translational perspectives. Psychiatrists wishing to integrate these novelties into their research will need to work with contributors with whom they are unaccustomed to working, such as computer experts, a multidisciplinary team, and stakeholders such as patients and caregivers. This process will allow us to further understand and alleviate the suffering and impairment of people with psychiatric disorders.
The Piúma lineament, southern Espirito Santo: structural expression and tectonic significance
Authors: Lourenço Fernanda Silva ,   PETROBRAS, BR, Alkmim Fernando Flecha de , Araújo Mário Neto Cavalcanti de , Romeiro Marco Antonio Thoaldo , Matos Gabriel Correa de , Crósta Alvaro Penteado ,   Universidade Federal de Ouro Preto, Brazil,   Universidade Estadual de Campinas, Brazil
Published: January 2017

ABSTRACT: The Piúma lineament, located in the Southern Espírito Santo State, Brazil, is one of the most prominent linear morphostructural features of the northern Mantiqueira Province. The lineament stands out in satellite images and topographic maps, extending for about 70 km in a N50°W direction, between the towns of Iconha and Conceição do Castelo (Espírito Santo). In order to investigate the nature and role played by the Piúma lineament in the tectonic evolution of the Mantiqueira Province and adjacent Campos Basin, we carried out a detailed structural analysis based on fieldwork, as well as geophysical data processing and interpretation. The results we obtained indicate that the Piúma lineament is a brittle shear zone characterized by N50W-trending and SW-dipping shear fractures, faults and joints. These structures record two distinct and incompatible motions, thereby recording the operation of two tectonic regimes: NNE-SSW extension and E-W transtension. Comparing our results with the literature on the Southeastern Brazilian Continental Margin, we conclude that the Piúma lineament more likely developed after the Ediacaran Brasiliano orogenic event in response to an NNE-SSW extension, experiencing later a reactivation as normal dextral to dextral transtensional zone, probably in connection with the South Atlantic rifting in the Lower Cretaceous.
Superposition of structures in the interference zone between the southern Brasília belt and the central Ribeira belt in the region SW of Itajubá (MG), SE Brazil
Authors: Vinagre Rodrigo ,   Universidade Federal do Rio de Janeiro, Brazil, Trouw Rudolph Allard Johannes , Kussama Hugo , Peternel Rodrigo , Mendes Julio Cezar , Duffles Patrícia ,   Universidade Estadual do Rio de Janeiro, Brazil,   Universidade Federal Rural do Rio de Janeiro, Brazil
Published: January 2017

ABSTRACT: The study area is localized in the Socorro nappe, part of the southern Brasília belt, with a minor part in the Embu terrane, part of the central Ribeira belt. Three phases of deformation were detected, Dn-1, Dn and Dn+1. Sn-1 seems to be generally transposed into Sn, but in the northwestern part it is well preserved, dipping about 60º to W and SW, with a stretching and/or mineral lineation plunging down dip. The main foliation in most of the area is Sn, dipping about 70º to SSE. Dn folds are tight to isoclinal, with axes that plunge about 40º to SW. Quartz-feldspathic segregation veins are folded by Dn. The structures related to Dn-1 and Dn are cut and modified by four important shear zones ascribed to deformation phase Dn+1. Two samples of a granite that is elongated along the Caxambu shear zone, and also cut by it, were dated. One yielded a crystallization age of 575 ± 5 Ma, and the other one, from the shear zone, an age of 567 ± 8 Ma, interpreted either as representing the age of movement along the Caxambu shear zone, or as metamorphic growth.
Predictive features for histology of gastric subepithelial lesions
Authors: SCHULZ Ricardo Teles , FABIO Lizandra Castilho , FRANCO Matheus Cavalcante , SIQUEIRA Sheila A , SAKAI Paulo , MALUF-FILHO Fauze
Published: January 2017

ABSTRACT BACKGROUND Gastric subepithelial lesion is a relatively common diagnosis after routine upper endoscopy. The diagnostic workup of an undetermined gastric subepithelial lesion should take into consideration clinical and endoscopic features. OBJECTIVE We aimed to investigate the association between patients' characteristics, endoscopic and echographic features with the histologic diagnosis of the gastric subepithelial lesions. METHODS This is a retrospective study with 55 patients, who were consecutively diagnosed with gastric subepithelial lesions, from October 2008 to August 2011. Patients' characteristics, endoscopic and echografic features of each gastric subepithelial lesion were analysed. Histologic diagnosis provided by EUS-guided fine needle aspiration or endoscopic/surgical resection was used as gold standard. RESULTS The probability of gastrointestinal stromal tumors to be located in the cardia was low (4.5%), while for leiomyoma it was high (>95%). In addition, there was a higher risk of gastrointestinal stromal tumors in patients older than 57 years (OR 8.9; 95% CI), with lesions ≥21 mm (OR 7.15; 95% CI), located at 4th layer (OR 18.8; 95% CI), with positive Doppler sign (OR 9; 95% CI), and irregular outer border (OR 7.75; 95% CI). CONCLUSION The location of gastric subepithelial lesions in the gastric cardia lowers the risk of gastrointestinal stromal tumors. While gastric subepithelial lesions occurring in elderly patients, located in the gastric body, with positive Doppler signal and irregular outer border increase the risk of gastrointestinal stromal tumors.
Is there an association between vitamin D and liver fibrosis in patients with chronic hepatitis C?
Authors: OLIVEIRA Kalinca da Silva , BUSS Caroline , TOVO Cristiane Valle
Published: January 2017

ABSTRACT BACKGROUND Vitamin D is known for its immunomodulatory, anti-inflammatory and antifibrotic properties, which are quite relevant in the pathogenesis and treatment of many causes of chronic liver disease. OBJECTIVE This study aimed to evaluate the association between serum vitamin D levels and the histopathological findings in patients with chronic hepatitis C virus infection. METHODS Cross-sectional study composed of patients with chronic hepatitis C. All patients underwent vitamin D 25 dosage and anthropometric data analysis. Liver biopsy was performed in a maximum 36-month period before inclusion in the study. RESULTS Of the 74 patients included in the study, 45 (60.8%) were women, mean age was 57.03±9.24 years, and 63 (85.1%) were white. No association was observed between the serum levels of vitamin D and inflammatory activity (P=0.699) nor with the degree of liver fibrosis (P=0.269). CONCLUSION In this study, no association was observed between vitamin D and inflammatory activity, as well as the degree of liver fibrosis, in patients with chronic hepatitis C.
Application of BAROS’ questionnaire in obese patients undergoing bariatric surgery with 2 years of evolution
Authors: QUEIROZ Caetano de , SALLET José Afonso , DE BARROS E SILVA Pedro Gabriel Melo , QUEIROZ Luzia da Gloria Pereira de Sousa , PIMENTEL Jélis Arenas , SALLET Paulo Clemente
Published: January 2017

ABSTRACT BACKGROUND -In recent decades, the high prevalence of obesity in the general population has brought serious concerns in terms of public health. Contrarily to conventional treatment involving dieting and physical exercising, often ineffective in generating long term results, bariatric operations have been an effective method for sustained weight loss in morbidly obese individuals. The Bariatric Analysis and Reporting Outcome System (BAROS) is an objective and recognized system in the overall evaluation of results after bariatric surgery. OBJECTIVE To investigate results concerning a casuistic of morbidly obese patients undergoing bariatric surgery over a 2-year follow-up in terms of weight loss, related medical conditions, safety and changes in quality of life. METHODS A total of 120 obese (17 male and 103 female) patients, who underwent bariatric surgery, were assessed and investigated using the BAROS system after a 2- year follow-up. RESULTS Patients obtained a mean excess weight loss of 74.6 (±15.9) % and mean body mass index reduction of 15.6 (±4.4) Kg/m2. Pre-surgical comorbidities were present in 71 (59%) subjects and they were totally (86%) or partially (14%) resolved. Complications resulting specifically from the surgical procedure were observed in 4.2% of cases (two bowel obstructions requiring re-operation, and three stomal stenosis treated with endoscopic dilation). Sixteen subjects (13% of total number of patients) presented minor clinical complications managed through outpatient care. The final scores for the BAROS questionnaire showcased excellent to good results in 99% of cases (excellent 44%, very good 38%, good 23%, acceptable 1%). CONCLUSION According to the BAROS questionnaire, bariatric surgery is a safe and effective method for managing obesity and associated clinical comorbidities, allowing for satisfactory results after a 2-year follow-up. Future studies should address other clinical and psychosocial variables that impact outcome as well as allow for longer follow-ups.
Use of cuff tear arthroplasty head prosthesis for rotator cuff arthropathy treatment in elderly patients with comorbidities
Authors: Carvalho Cassiano Diniz ,   Universidade Federal de São Paulo,  Brazil, Andreoli Carlos Vicente , Pochini Alberto de Castro , Ejnisman Benno
Published: January 2017

ABSTRACT Objective To evaluate the clinical and functional behavior of patients undergoing cuff tear arthroplasty at different stages of the disease. Methods Cuff tear arthroplasty hemiarthroplasties were performed in 34 patients with rotator cuff arthropathy and associated comorbidities, classified according to Seebauer. The mean age was 76.3 years, and the sample comprised 23 females (67.6%) and 11 males (32.4%). The mean follow-up period was 21.7 months, and evaluations were performed using the Visual Analog Scale for pain and the Constant scale. Results There were no statistically significant differences in the mean reduction in the Visual Analog Scale or in the Constant scale increase between the female and male groups. The variation between the pre- and postoperative Visual Analog Scale and Constant scale evaluations was significant. There was also no statistically significant difference between the Seebauer classification groups regarding the mean Visual Analog Scale reduction, or the mean Constant scale increase. Conclusion Cuff tear arthroplasty shoulder hemiarthroplasty is a good option for rotator cuff arthropathy in patients with comorbidities.
Retrospective analysis of a case series of patients with traumatic injuries to the craniocervical junction
Authors: Esteves Luiz Adriano ,   Universidade Estadual de Campinas, Brazil, Joaquim Andrei Fernandes , Tedeschi Helder ,   Núcleo do Hospital de Força Aérea de São Paulo, Brazil
Published: January 2017

ABSTRACT Objective To evaluate the correlation between the treatment, the characteristics of the lesions and the clinical outcome of patients with traumatic injuries to the craniocervical junction. Methods This was a retrospective study of patients treated conservatively or surgically between 2010 and 2013 with complete data sets. Results We analyzed 37 patients, 73% were men with mean age of 41.7 years. Of these, 32% were submitted to initial surgical treatment and 68% received conservative treatment. Seven (29%) underwent surgery subsequently. In the surgical group, there were seven cases of odontoid type II fractures, two cases of fracture of posterior elements of the axis, one case of C1-C2 dislocation with associated fractured C2, one case of occipitocervical dislocation, and one case of combined C1 and C2 fractures, and facet dislocation. Only one patient had neurological déficit that improved after treatment. Two surgical complications were seen: a liquoric fistula and one surgical wound infection (reaproached). In the group treated conservatively, odontoid fractures (eight cases) and fractures of the posterior elements of C2 (five cases) were more frequent. In two cases, in addition to the injuries of the craniocervical junction, there were fractures in other segments of the spine. None of the patients who underwent conservative treatment presented neurological deterioration. Conclusion Although injuries of craniocervical junction are relatively rare, they usually involve fractures of the odontoid and the posterior elements of the axis. Our results recommend early surgical treatment for type II odontoid fractures and ligament injuries, the conservative treatment for other injuries.
Brachial insertion of fully implantable venous catheters for chemotherapy: complications and quality of life assessment in 35 patients
Authors: Fonseca Igor Yoshio Imagawa ,   Hospital A. C. Camargo, Brazil, Krutman Mariana , Nishinari Kenji , Yazbek Guilherme , Teivelis Marcelo Passos , Bomfim Guilherme André Zottele , Cavalcante Rafael Noronha , Wolosker Nelson ,   Hospital Israelita Albert Einstein, Brazil
Published: January 2017

ABSTRACT Objective To prospectively evaluate the perioperative safety, early complications and satisfaction of patients who underwent the implantation of central catheters peripherally inserted via basilic vein. Methods Thirty-five consecutive patients with active oncologic disease requiring chemotherapy were prospectively followed up after undergoing peripheral implantation of indwelling venous catheters, between November 2013 and June 2014. The procedures were performed in the operating room by the same team of three vascular surgeons. The primary endpoints assessed were early postoperative complications, occurring within 30 days after implantation. The evaluation of patient satisfaction was based on a specific questionnaire used in previous studies. Results In all cases, ultrasound-guided puncture of the basilic vein was feasible and the procedure successfully completed. Early complications included one case of basilic vein thrombophlebitis and one case of pocket infection that did not require device removal. Out of 35 patients interviewed, 33 (94.3%) would recommend the device to other patients. Conclusion Implanting brachial ports is a feasible option, with low intraoperative risk and similar rates of early postoperative complications when compared to the existing data of the conventional technique. The patients studied were satisfied with the device and would recommend the procedure to others.
Oral health evaluation in special needs individuals
Authors: Pini Danielle de Moraes ,   Faculdade Meridional,  Brazil, Fröhlich Paula Cristina Gil Ritter , Rigo Lilian
Published: January 2017

ABSTRACT Objective To identify the prevalence of the main oral problems present in special needs children and to relate the underlying conditions with the clinical and demographic variables. Methods The study was based on the physical examination of 47 students from the Associação de Pais e Amigos dos Excepcionais diagnosed as Down syndrome, cerebral palsy and intellectual deficit. For data collection, we used a self-administered questionnaire that included indices of dental caries and oral hygiene, Angle classification, malposition of dental groups and oral hygiene habits. Results The predominant age group was 12-25 years (46.8%) and most patients were male (55.3%). Regarding daily brushing, 63.8% reported brushing their teeth three times a day, and 85.1% did it by themselves. A total of 48.9% were rated as Angle class I, and 25.5% had no type of malocclusion. A high dental carries index (decayed, missing, filled >10) was observed in 44.7%, and 53.2% had inadequate oral hygiene (zero to 1.16). There was a statistically significant difference between cerebral palsy and the act of the participants brushing their teeth by themselves. Conclusion There was a high decayed-missing-filled teeth index and malocclusion class I, as well as inadequate oral hygiene. The type of underlying condition of the participants influenced the act of brushing teeth by themselves.
Minor intraoral salivary gland tumors: a clinical-pathological study
Authors: Sarmento Dmitry José de Santana ,   Universidade Estadual da Paraíba, Brazil, Morais Maria de Lourdes Silva de Arruda , Costa Antonio de Lisboa Lopes , Silveira Éricka Janine Dantas da ,   Universidade Federal do Rio Grande do Norte, Brazil
Published: January 2017

ABSTRACT Objective To evaluate the clinical-pathological profile of patients with minor salivary gland neoplasms. Methods A retrospective study of specific cases diagnosed as benign and malignant tumors of the minor salivary glands was performed. The data were collected from medical records of patients seen at a hospital over a period of 15 years. The sample was made up of 37 cases. For the pathological study, slides containing 5μm thick sections stained with hematoxylin and eosin were used. The data were tabulated using descriptive statistics. Results Malignant neoplasms represented 70.3% of cases. The mucoepidermoid carcinoma was the most common neoplasm (45.9%), followed by pleomorphic adenoma (24.4%). Most patients were female (70.3%), aged between 71 and 80 years. The palate (67.6%) and the retromolar region (10.8%) were the most affected sites. Conclusion Mucoepidermoid carcinoma was the most common tumor in minor salivary glands. These tumors are more common in females aged over 40 years. The palate was the most common affected site.
Effect of maternal exercises on biophysical fetal and maternal parameters: a transversal study
Authors: Santos Caroline Mombaque dos ,   Universidade Federal de Santa Maria,  Brazil, Santos Wendel Mombaque dos , Gallarreta Francisco Maximiliano Pancich , Pigatto Camila , Portela Luiz Osório Cruz , Morais Edson Nunes de
Published: January 2017

ABSTRACT Objective To evaluate the acute effects of maternal and fetal hemodynamic responses in pregnant women submitted to fetal Doppler and an aerobic physical exercise test according to the degree of effort during the activity and the impact on the well-being. Methods Transversal study with low risk pregnant women, obtained by convenience sample with gestational age between 26 to 34 weeks. The participants carry out a progressive exercise test. Results After the exercise session, reduced resistance (p=0.02) and pulsatility indices (p=0.01) were identified in the umbilical artery; however, other Doppler parameters analyzed, in addition to cardiotocography and fetal biophysical profile did not achieve significant change. Maternal parameters obtained linear growth with activity, but it was not possible to establish a standard with the Borg scale, and oxygen saturation remained stable. Conclusion A short submaximal exercise had little effect on placental blood flow after exercise in pregnancies without complications, corroborating that healthy fetus maintains homeostasis even in situations that alter maternal hemodynamics.
Extracellular adenosine 5’-triphosphate concentrations changes in rat spinal cord associated with the activation of urinary bladder afferents. A microdialysis study
Authors: Rocha Jeová Nina ,   Universidade de São Paulo, Brazil
Published: January 2017

ABSTRACT Objective To determine adenosine 5’-triphosphate levels in the interstice of spinal cord L6-S1 segment, under basal conditions or during mechanical and chemical activation of urinary bladder afferents. Methods A microdialysis probe was transversally implanted in the dorsal half of spinal cord L6-S1 segment in female rats. Microdialysate was collected at 15 minutes intervals during 135 minutes, in anesthetized animals. Adenosine 5’-triphosphate concentrations were determined with a bioluminescent assay. In one group of animals (n=7) microdialysate samples were obtained with an empty bladder during a 10-minutes bladder distension to 20 or 40cmH2O with either saline, saline with acetic acid or saline with capsaicin. In another group of animals (n=6) bladder distention was performed and the microdialysis solution contained the ectonucleotidase inhibitor ARL 67156. Results Basal extracellular adenosine triphosphate levels were 110.9±35.34fmol/15 minutes, (mean±SEM, n=13), and bladder distention was associated with a significant increase in adenosine 5’-triphosphate levels which was not observed after bladder distention with saline solution containing capsaicin (10µM). Microdialysis with solution containing ARL 67156 (1mM) was associated with significantly higher extracellular adenosine 5’-triphosphate levels and no further increase in adenosine 5’-triphosphate was observed during bladder distension. Conclusion Adenosine 5’-triphosphate was present in the interstice of L6-S1 spinal cord segments, was degraded by ectonucleotidase, and its concentration increased following the activation of bladder mechanosensitive but not of the chemosensitive afferents fibers. Adenosine 5’-triphosphate may originate either from the central endings of bladder mechanosensitive primary afferent neurons, or most likely from intrinsic spinal neurons, or glial cells and its release appears to be modulated by capsaicin activated bladder primary afferent or by adenosine 5’-triphosphate itself.
Incidence of Y-chromosome microdeletions in children whose fathers underwent vasectomy reversal or in vitro fertilization with epididymal sperm aspiration: a case-control study
Authors: Ghirelli-Filho Milton ,   Faculdade de Medicina do ABC, Brazil, Marchi Patricia Leme de , Mafra Fernanda Abani , Cavalcanti Viviane , Christofolini Denise Maria , Barbosa Caio Parente , Bianco Bianca , Glina Sidney ,   Hospital Israelita Albert Einstein, Brazil
Published: January 2017

ABSTRACT Objective To evaluate the incidence of Y-chromosome microdeletions in individuals born from vasectomized fathers who underwent vasectomy reversal or in vitro fertilization with sperm retrieval by epididymal aspiration (percutaneous epididymal sperm aspiration). Methods A case-control study comprising male children of couples in which the man had been previously vasectomized and chose vasectomy reversal (n=31) or in vitro fertilization with sperm retrieval by percutaneous epididymal sperm aspiration (n=30) to conceive new children, and a Control Group of male children of fertile men who had programmed vasectomies (n=60). Y-chromosome microdeletions research was performed by polymerase chain reaction on fathers and children, evaluating 20 regions of the chromosome. Results The results showed no Y-chromosome microdeletions in any of the studied subjects. The incidence of Y-chromosome microdeletions in individuals born from vasectomized fathers who underwent vasectomy reversal or in vitro fertilization with spermatozoa recovered by percutaneous epididymal sperm aspiration did not differ between the groups, and there was no difference between control subjects born from natural pregnancies or population incidence in fertile men. Conclusion We found no association considering microdeletions in the azoospermia factor region of the Y chromosome and assisted reproduction. We also found no correlation between these Y-chromosome microdeletions and vasectomies, which suggests that the assisted reproduction techniques do not increase the incidence of Y-chromosome microdeletions.
Quality Program: what influences the opinion of nursing team
Authors: Costa Fernanda Mazzoni da ,   Universidade Federal de Juiz de Fora, Brazil, Souza Irene Duarte , Monteiro Maria Inês , Lopes Maria Helena Baena de Moraes , Greco Rosangela Maria ,   Universidade Estadual de Campinas, Brazil,   Universidade Federal de Juiz de Fora, Brazil
Published: January 2017

ABSTRACT Objective To analyze the major impact variables in the opinion of nursing staff about the Quality Program of a teaching hospital. Methods An exploratory-descriptive study was performed with 72 nursing staff. Data were collected through self-administered questionnaire containing 24 statements about the Quality Program; and the degree of agreement of the participants was expressed in a Likert scale. The collected data were analyzed by factor analysis and Pearson’s correlation coefficient. Results The analysis grouped the statements in six factors. The Pearson’s correlation coefficient defined a scale of influence of the variables within each factor, whose variable with the greatest impact in each factor is the priority issue for improving worker opinion about the Quality Program. The priority variables were to believe the Quality Program contributes to the hospital; to understand the program orientations; interest in hospital quality direction; and do not feel exhausted due to the program. Conclusion These variables must be focused during the implementation and execution of Quality Program, as they have greater impact on improving opinion regarding the Quality Program and thus helping to increase compliance of the nursing staff to the program.
Intraoperative near-infrared fluorescent imaging during robotic operations
Authors: Macedo Antonio Luiz de Vasconcellos , Schraibman Vladimir
Published: January 2017

ABSTRACT The intraoperative identification of certain anatomical structures because they are small or visually occult may be challenging. The development of minimally invasive surgery brought additional difficulties to identify these structures due to the lack of complete tactile sensitivity. A number of different forms of intraoperative mapping have been tried. Recently, the near-infrared fluorescence imaging technology with indocyanine green has been added to robotic platforms. In addition, this technology has been tested in several types of operations, and has advantages such as safety, low cost and good results. Disadvantages are linked to contrast distribution in certain clinical scenarios. The intraoperative near-infrared fluorescent imaging is new and promising addition to robotic surgery. Several reports show the utility of this technology in several different procedures. The ideal dose, time and site for dye injection are not well defined. No high quality evidence-based comparative studies and long-term follow-up outcomes have been published so far. Initial results, however, are good and safe.
Isolated primary amyloidosis of the inferior rectus muscle mimicking Graves’ orbitopathy
Authors: Monteiro Mário Luiz Ribeiro ,   Universidade de São Paulo,  Brazil, Gonçalves Allan Christian Pieroni , Bezerra Alanna Mara Pinheiro Sobreira ,   Hospital Israelita Albert Einstein,  Brazil
Published: January 2017

ABSTRACT The diagnosis of Graves’ orbitopathy is usually straightforward. However, orbital diseases that mimick some clinical signs of Graves’ orbitopathy may cause diagnostic confusion, particularly when associated to some form of thyroid dysfunction. This report describes the rare occurrence of localized inferior rectus muscle amyloidosis in a patient with autoimmune hypothyroidism, who was misdiagnosed as Graves’ orbitopathy. A 48-year-old man complained of painless progressive proptosis on the left side and intermittent vertical diplopia for 6 months. The diagnosis of Graves’ orbitopathy was entertained after magnetic resonance imaging revealing a markedly enlarged, tendon-sparing inferior rectus enlargement on the left side, and an autoimmune hypothyroidism was disclosed on systemic medical workup. After no clinical improvement with treatment, the patient was referred to an ophthalmologist and further investigation was performed. The presence of calcification in the inferior rectus muscle on computed tomography, associated with the clinical findings led to a diagnostic biopsy, which revealed amyloid deposition. This report emphasizes that a careful evaluation of atypical forms of Graves’ orbitopathy may be crucial and should include, yet with rare occurrence, amyloidosis in its differential diagnosis.
Giant gastric lipossarcoma: case report and review of the literature
Authors: Matone Jacques ,   Hospital Israelita Albert Einstein,  Brazil, Okazaki Samuel , Maccapani Gabriel Naman , Amancio Thiago Trolez , Filippi Renée Zon , Macedo Antonio Luiz de Vasconcellos
Published: January 2017

ABSTRACT Liposarcoma is one of the most common soft tissue sarcomas in adults, occurring in 15 to 20% of all patients with sarcoma. Primary liposarcoma of the stomach is rare. We report a case of patient with giant gastric liposarcoma who underwent surgery after a gastrointestinal bleeding. Preoperative hystopathological diagnosis was not established, even after three biopsy attempts. We discuss differential diagnosis, genetic causes, diagnosis strategies and treatment.
Vascular access: the impact of ultrasonography
Authors: Almeida Carlos Eduardo Saldanha de ,   Hospital Israelita Albert Einstein, Brazil
Published: January 2017

ABSTRACT Vascular punctures are often necessary in critically ill patients. They are secure, but not free of complications. Ultrasonography enhances safety of the procedure by decreasing puncture attempts, complications and costs. This study reviews important publications and the puncture technique using ultrasound, bringing part of the experience of the intensive care unit of the Hospital Israelita Albert Einstein, São Paulo (SP), Brazil, and discussing issues that should be considered in future studies.
Effects of positive expiratory pressure on pulmonary clearance of aerosolized technetium-99m-labeled diethylenetriaminepentaacetic acid in healthy individuals
Authors: Albuquerque Isabella Martins de ,   Universidade Federal de Santa Maria, Brazil, Cardoso Dannuey Machado , Masiero Paulo Ricardo , Paiva Dulciane Nunes , Resqueti Vanessa Regiane , Fregonezi Guilherme Augusto de Freitas , Menna-Barreto Sérgio Saldanha ,   Universidade de Santa Cruz do Sul, Brazil,   Universidade Federal do Rio Grande do Sul, Brazil,   Universidade de Santa Cruz do Sul, Brazil,   Universidade Federal do Rio Grande do Norte, Brazil,   Universidade Federal do Rio Grande do Sul, Brazil
Published: January 2017

ABSTRACT Objective: To evaluate the effects of positive expiratory pressure (PEP) on pulmonary epithelial membrane permeability in healthy subjects. Methods: We evaluated a cohort of 30 healthy subjects (15 males and 15 females) with a mean age of 28.3 ± 5.4 years, a mean FEV1/FVC ratio of 0.89 ± 0.14, and a mean FEV1 of 98.5 ± 13.1% of predicted. Subjects underwent technetium-99m-labeled diethylenetriaminepentaacetic acid (99mTc-DTPA) radioaerosol inhalation lung scintigraphy in two stages: during spontaneous breathing; and while breathing through a PEP mask at one of three PEP levels-10 cmH2O (n = 10), 15 cmH2O (n = 10), and 20 cmH2O (n = 10). The 99mTc-DTPA was nebulized for 3 min, and its clearance was recorded by scintigraphy over a 30-min period during spontaneous breathing and over a 30-min period during breathing through a PEP mask. Results: The pulmonary clearance of 99mTc-DTPA was significantly shorter when PEP was applied-at 10 cmH2O (p = 0.044), 15 cmH2O (p = 0.044), and 20 cmH2O (p = 0.004)-in comparison with that observed during spontaneous breathing. Conclusions: Our findings indicate that PEP, at the levels tested, is able to induce an increase in pulmonary epithelial membrane permeability and lung volume in healthy subjects.
Mouthpiece ventilation in Duchenne muscular dystrophy: a rescue strategy for noncompliant patients
Authors: Fiorentino Giuseppe ,   Ospedale Monaldi di Napoli,  Italia, Annunziata Anna , Cauteruccio Rosa , Frega Gianfranco Scotto di , Esquinas Antonio ,   Hospital General Morales Meseguer,  España
Published: January 2017

ABSTRACT Objective: To evaluate mouthpiece ventilation (MPV) in patients with Duchenne muscular dystrophy (DMD) who are noncompliant with noninvasive ventilation (NIV). Methods: We evaluated four young patients with DMD who had previously refused to undergo NIV. Each patient was reassessed and encouraged to try MPV. Results: The four patients tolerated MPV well and were compliant with NIV at home. MPV proved to be preferable and more comfortable than NIV with any other type of interface. Two of the patients required overnight NIV and eventually agreed to use a nasal mask during the night. Conclusions: The advantages of MPV over other types of NIV include fewer speech problems, better appearance, and less impact on the patient, eliminating the risk of skin breakdown, gastric distension, conjunctivitis, and claustrophobia. The use of a mouthpiece interface should be always considered in patients with DMD who need to start NIV, in order to promote a positive approach and a rapid acceptance of NIV. Using MPV during the daytime makes patients feel safe and more likely to use NIV at night. In addition, MPV increases treatment compliance for those who refuse to use other types of interfaces.
Pulmonary function in children and adolescents with sickle cell disease: have we paid proper attention to this problem?
Authors: Vieira Ana Karine ,   Fundação Hemominas, Brasil, Alvim Cristina Gonçalves , Carneiro Maria Cristina Marquez , Ibiapina Cássio da Cunha ,   Universidade Federal de Minas Gerais, Brazil,   Universidade Federal de Minas Gerais, Brazil,   Universidade Federal de Minas Gerais, Brazil
Published: January 2017

ABSTRACT Objective: To evaluate pulmonary function and functional capacity in children and adolescents with sickle cell disease. Methods: This was a cross-sectional study involving 70 children and adolescents (8-15 years of age) with sickle cell disease who underwent pulmonary function tests (spirometry) and functional capacity testing (six-minute walk test). The results of the pulmonary function tests were compared with variables related to the severity of sickle cell disease and history of asthma and of acute chest syndrome. Results: Of the 64 patients who underwent spirometry, 15 (23.4%) showed abnormal results: restrictive lung disease, in 8 (12.5%); and obstructive lung disease, in 7 (10.9%). Of the 69 patients who underwent the six-minute walk test, 18 (26.1%) showed abnormal results regarding the six-minute walk distance as a percentage of the predicted value for age, and there was a ≥ 3% decrease in SpO2 in 36 patients (52.2%). Abnormal pulmonary function was not significantly associated with any of the other variables studied, except for hypoxemia and restrictive lung disease. Conclusions: In this sample of children and adolescents with sickle cell disease, there was a significant prevalence of abnormal pulmonary function. The high prevalence of respiratory disorders suggests the need for a closer look at the lung function of this population, in childhood and thereafter.
An initial experience with a digital drainage system during the postoperative period of pediatric thoracic surgery
Authors: Costa Jr Altair da Silva , Bachichi Thiago , Holanda Caio , Rizzo Luiz Augusto Lucas Martins De
Published: January 2017

ABSTRACT Objective: To report an initial experience with a digital drainage system during the postoperative period of pediatric thoracic surgery. Methods: This was a prospective observational study involving consecutive patients, ≤ 14 years of age, treated at a pediatric thoracic surgery outpatient clinic, for whom pulmonary resection (lobectomy or segmentectomy via muscle-sparing thoracotomy) was indicated. The parameters evaluated were air leak (as quantified with the digital system), biosafety, duration of drainage, length of hospital stay, and complications. The digital system was used in 11 children (mean age, 5.9 ± 3.3 years). The mean length of hospital stay was 4.9 ± 2.6 days, the mean duration of drainage was 2.5 ± 0.7 days, and the mean drainage volume was 270.4 ± 166.7 mL. The mean maximum air leak flow was 92.78 ± 95.83 mL/min (range, 18-338 mL/min). Two patients developed postoperative complications (atelectasis and pneumonia, respectively). The use of this digital system facilitated the decision-making process during the postoperative period, reducing the risk of errors in the interpretation and management of air leaks.
Renal Collectrin Protects against Salt-Sensitive Hypertension and Is Downregulated by Angiotensin II
Authors: Chu Pei-Lun , Gigliotti Joseph C. , Cechova Sylvia , Bodonyi-Kovacs Gabor , Chan Fang , Ralph Donna Lee , Howell Nancy , Kalantari Kambiz , Klibanov Alexander L. , Carey Robert M. , McDonough Alicia A. , Le Thu H.
Published: January 2017

Collectrin, encoded by the Tmem27 gene, is a transmembrane glycoprotein with approximately 50% homology with angiotensin converting enzyme 2, but without a catalytic domain. Collectrin is most abundantly expressed in the kidney proximal tubule and collecting duct epithelia, where it has an important role in amino acid transport. Collectrin is also expressed in endothelial cells throughout the vasculature, where it regulates L-arginine uptake. We previously reported that global deletion of collectrin leads to endothelial dysfunction, augmented salt sensitivity, and hypertension. Here, we performed kidney crosstransplants between wild-type (WT) and collectrin knockout (Tmem27Y/-
) mice to delineate the specific contribution of renal versus extrarenal collectrin on BP regulation and salt sensitivity. On a high-salt diet, WT mice with Tmem27Y/-
kidneys had the highest systolic BP and were the only group to exhibit glomerular mesangial hypercellularity. Additional studies showed that, on a high-salt diet, Tmem27Y/-
mice had lower renal blood flow, higher abundance of renal sodium-hydrogen antiporter 3, and lower lithium clearance than WT mice. In WT mice, administration of angiotensin II for 2 weeks downregulated collectrin expression in a type 1 angiotensin II receptor–dependent manner. This downregulation coincided with the onset of hypertension, such that WT and Tmem27Y/-
mice had similar levels of hypertension after 2 weeks of angiotensin II administration. Altogether, these data suggest that salt sensitivity is determined by intrarenal collectrin, and increasing the abundance or activity of collectrin may have therapeutic benefits in the treatment of hypertension and salt sensitivity.
Moving Biomarkers toward Clinical Implementation in Kidney Transplantation
Authors: Menon Madhav C. , Murphy Barbara , Heeger Peter S.
Published: January 2017

Long-term kidney transplant outcomes remain suboptimal, delineating an unmet medical need. Although current immunosuppressive therapy in kidney transplant recipients is effective, dosing is conventionally adjusted empirically on the basis of time after transplant or altered in response to detection of kidney dysfunction, histologic evidence of allograft damage, or infection. Such strategies tend to detect allograft rejection after significant injury has already occurred, fail to detect chronic subclinical inflammation that can negatively affect graft survival, and ignore specific risks and immune mechanisms that differentially contribute to allograft damage among transplant recipients. Assays and biomarkers that reliably quantify and/or predict the risk of allograft injury have the potential to overcome these deficits and thereby, aid clinicians in optimizing immunosuppressive regimens. Herein, we review the data on candidate biomarkers that we contend have the highest potential to become clinically useful surrogates in kidney transplant recipients, including functional T cell assays, urinary gene and protein assays, peripheral blood cell gene expression profiles, and allograft gene expression profiles. We identify barriers to clinical biomarker adoption in the transplant field and suggest strategies for moving biomarker-based individualization of transplant care from a research hypothesis to clinical implementation.
Microfluidics Lithography 1: Spin Coating v1
Authors: Sevli Serhat , Seyfullah Yilmaz not provided , C. Yunus Sahan not provided
Published: January 2017

Nehir Biyoteknoloji Ltd. www.nehirbt.com
Protocols for The Healthy Brain Network Serial Scanning Initiative (Sessions 1-14) v1
Authors: O'Connor David
Published: January 2017

These protocols accompany the following publication: David O'Connor, et. al. (2017) The Healthy Brain Network Serial Scanning Initiative. GigaScience...
A study on clinical outcome of obstructed labour
Authors: Indra . , N. Usharani , Bendigeri Mumtaz
Published: January 2017

Background: Obstructed labour accounts for 8% of maternal mortality in developing countries. Obstructed labour is the single most important cause of maternal death and is one of the three leading causes of perinatal mortality with the case fatality rate of 87-100%.Methods: The 50 patients with prolonged labour and maternal distress with signs and symptoms of maternal exhaustion, dehydration, keto-acidosis, Bandl’s ring formed the study subjects.Results: Out of the 50 cases studied the still birth rate was 24% (12 cases). This was due to delay in the referring the cases from peripheral centers.Conclusions: Our peripheral hospital need appointment of qualified personnel and well trained staff, who can recognize any deviation from normal labour and recognize malpresentation and malposition at the earliest and refer such cases to higher centers.
Spectrum of vascular abnormalities in color Doppler examination of upper extremities tested for suitability for AV fistula creation in patients of renal failure
Authors: Grover Seema , Bolisetti Suprabhat , Sangani Shailesh , Gadhavi Sonali , Kulkarni Neeraja
Published: January 2017

Background: Almost all patients with end stage renal disease require haemodialysis at some stage of their disease and arteriovenous fistula is the most convenient option. The purpose of this study was to analyse the prevalence of vascular abnormalities in the upper limbs of patients posted for creation of haemodialysis access. Knowledge of the variant anatomy of upper limb vessels helps in better planning of surgery, avoiding unnecessary surgery and improving the success rate of haemodialysis access creation.Methods: This study is a retrospective analysis of colour Doppler study of 150 upper extremities of end stage renal disease patients posted for AV fistula creation. The limbs were evaluated for arterial and venous anatomy rendering them fit or unfit for fistula creation.Results: We found abnormal vasculature in more than 60% of the upper limbs. Congenital arterial abnormality was found in 9 % of upper limbs and venous abnormality was found in 65 % of upper limbs. Unnecessary surgery could be avoided in approximately 74 % of patients. 10 % had correctable abnormality.Conclusions: Pre-operative ultrasound and Doppler assessment resulted in more patients being subjected to proximal fistulas and alternate suitable dialysis processes like permcath or peritoneal dialysis. Primary fistula success rate obtained by this pre-operative evaluation was close to 95 %.
Análisis De Representaciones Gráficas Cartesianas En Libros De Texto De Biología
Authors: Artola Eugenia Cristina , Nouveliere Liliana Esther Mayoral , Benarroch Alicia Benarroch
Published: January 2017

Graphical representations Cartesian (RGC) are important communication tools in different areas of knowledge and in particular in the Population Biology (BP). The teaching of this area can be strongly affected by the difficulties that students encounter in the interpretation and use of the RGC. In this paper the analysis of RGC in ten textbooks and eight Secondary Education Teacher Training Biology, most widespread in the Province of Mendoza (Argentina), intended to compare and contrast their results is made. The analysis of character ontosemiotic involves both the text and the images, and uses a set of indicators associated with the semiotic concepts of relevance, appropriateness and didactic suitability, based on previous research. We conclude that the books of Teacher Education use a greater amount of RGC and generate as many positive interactions in their school books readers. They are therefore most flattering of inter-linguistic semiotic interactions and relationships between mathematical and biological language. However, they are a source of potential conflict, like school, largely because of lack of clarification of meanings of symbolic notations.
The Role of Communication and Information Technology in the Health Care Providing Office
Authors: Monea Monica , Pop Anca Maria , Peter Olah
Published: January 2017

Health informatics technology includes the information technology and electronics employed during medical care procedures and is generally known as clinical informatics. The definition of this specialty was given by the American Medical Information Association in order to describe the role of communication systems in improving the doctor-patient relationship and the quality of medical care. The aim of our investigation was to evaluate the frequency of computer based methods use by medical personnel during daily basic activities in a private dental office. An original questionnaire was sent to a target group of 200 dentists with private dental practice from Mureș County, Romania, with an age between 30-55 years with a private practice opened for at least 2 years. For statistical analysis we used SPSS (Statistical Package for Social Science, version 10.1). The evaluation of results showed that dental software is considered by the majority of respondents to have an important role in improving the quality of medical act and elimination of time consuming procedures.
Contribution A L’etude De La Biologie Florale De Quelques Rosacees Cultivees De La Region De Constantine (Algerie)
Authors: Ahlem Bousmid , Mouad Boulacel , Mostef Benlaribi
Published: January 2017

Angiosperms largely dominated the current terrestrial flora, with more than 275,000 species already identified (Meyer et al., 2008). Several major characteristics associated with sexual reproduction distinguish this group of plants, making this the most advanced subphylum Phanerogams(Robert et al., 1998). A quick review of flora reveals the wide variety of shapes and floral structures in different families of angiosperms. This diversity is the basis of the key determination and classification or systematic of flowering plants. Rosaceae that constitute our subject of study have a constant organization and regular flower type 5: 5 sepals, 5 petals, many stamens, one or more carpels. In our work we investigated a few dominant species cultivated in our study area such as: Cydonia oblonga Mill., Eriobotrya japonica Thun., Malus domestica Borkh., Prunus domestica L., Prunus dulcis Mill., Prunus persica L., Pyrus communis L. After collecting flowers and extraction of pollen grains, observations with binocular and light microscope there emerges a diversity materialized ia in: - Flower color; - The presence or absence of fuzz around the reproductive organs that are protected temperatures decreases. This allows for example medlar and almond reproduce during cold periods of the year (December, January, February).