bluuebunny/crossref_metadata_2025 huggingface dataset:
Adiposity, Insulin Resistance, and Bone Mass in Children and Adolescents
Authors: Kindler Joseph M , Lobene Andrea J , Vogel Kara A , Martin Berdine R , McCabe Linda D , Peacock Munro , Warden Stuart J , McCabe George P , Weaver Connie M
Published: October 2018

Context

Insulin resistance is an adverse health outcome that accompanies obesity. Fat mass is negatively associated with the bone mass after adjustment for confounders. Insulin resistance might be an intermediary in this relationship.

Objective

To determine whether insulin resistance is an intermediary in the relationship between adiposity and bone mass in adolescents.

Design

Cross-sectional secondary analysis of baseline data from a previous randomized trial.

Setting

University research facility.

Participants

A total of 240 adolescents (68% female), aged 7 to 15 years.

Main Outcome Measures

Using dual energy x-ray absorptiometry, bone mineral content (BMC), areal bone mineral density, lean mass, and fat mass were measured. Skeletal sites of interest included the total body and lumbar spine (LS). Waist circumference was measured using an anthropometric tape measure. Insulin and glucose were measured in fasting sera, and the homeostasis model assessment of insulin resistance (HOMA-IR) was calculated. Path analysis was performed to determine whether the relationship between adiposity and bone was mediated through insulin resistance.

Results

Fat mass (r = 0.467; P < 0.001) and waist circumference (r = 0.487; P < 0.001) correlated positively with HOMA-IR. Controlling for race, sex, maturation, lean mass, and height, fat mass, waist circumference, and HOMA-IR were negatively associated with LS BMC and total body areal bone mineral density (P < 0.05 for all). Additionally, path models for fat mass (95% CI, −5.893 to −0.956) and waist circumference (95% CI, −15.473 to −2.124) showed a negative relationship with LS BMC via HOMA-IR.

Conclusions

These results support an intermediary role of insulin resistance in the relationship between adiposity and LS bone mass.
SRF'ing and SAP'ing – the role of MRTF proteins in cell migration
Authors: Gau David , Roy Partha
Published: October 2018

Actin-based cell migration is a fundamental cellular activity that plays a crucial role in a wide range of physiological and pathological processes. An essential feature of the remodeling of actin cytoskeleton during cell motility is the de novo synthesis of factors involved in the regulation of the actin cytoskeleton and cell adhesion in response to growth-factor signaling, and this aspect of cell migration is critically regulated by serum-response factor (SRF)-mediated gene transcription. Myocardin-related transcription factors (MRTFs) are key coactivators of SRF that link actin dynamics to SRF-mediated gene transcription. In this Review, we provide a comprehensive overview of the role of MRTF in both normal and cancer cell migration by discussing its canonical SRF-dependent as well as its recently emerged SRF-independent functions, exerted through its SAP domain, in the context of cell migration. We conclude by highlighting outstanding questions for future research in this field.
Chimeric padlock and iLock probes for increased efficiency of targeted RNA detection
Authors: Krzywkowski Tomasz , Kühnemund Malte , Nilsson Mats
Published: October 2018

Many approaches exist to detect RNA using complementary oligonucleotides. DNA ligation-based techniques can improve discrimination of subtle sequence variations, but they have been difficult to implement for direct RNA analysis due to the infidelity and inefficiency of most DNA ligases on RNA. In this report, we have systematically studied if ribonucleotide substitutions in padlock probes can provide higher catalytic efficiencies for Chlorella virus DNA ligase (PBCV-1 DNA ligase) and T4 RNA ligase 2 (T4Rnl2) on RNA. We provide broad characterization of end-joining fidelity for both enzymes in RNA-templated 3′-OH RNA/5′-pDNA chimeric probe ligation. Both ligases showed increased ligation efficiency toward chimeric substrates on RNA. However, end-joining fidelity of PBCV-1 DNA ligase remained poor, while T4Rnl2 showed a somewhat better end-joining fidelity compared to PBCV-1 DNA ligase. The recently presented invader padlock (iLock) probes overcome the poor end-joining fidelity of PBCV-1 DNA ligase by the requirement of target-dependent 5′ flap removal prior to ligation. Here we show that two particular ribonucleotide substitutions greatly improve the activation and ligation rate of chimeric iLock probes on RNA. We characterized the end-joining efficiency and fidelity of PBCV-1 DNA ligase and T4Rnl2 with chimeric iLock probes on RNA and found that both enzymes exhibit high ligation fidelities for single nucleotide polymorphisms on RNA. Finally, we applied the chimeric probe concept to directly differentiate between human and mouse ACTB mRNA in situ, demonstrating chimeric padlock and iLock probes as superior to their DNA equivalents.
The case for openness in engineering research
Authors: Berg Devin R. , Niemeyer Kyle E.
Published: October 2018

In this article, we describe our views on the benefits, and possible downsides, of openness in engineering research. We attempt to examine the issue from multiple perspectives, including reasons and motivations for introducing open practices into an engineering researcher's workflow and the challenges faced by scholars looking to do so. Further, we present our thoughts and reflections on the role that open engineering research can play in defining the purpose and activities of the university. We have made some specific recommendations on how the public university can recommit to and push the boundaries of its role as the creator and promoter of public knowledge. In doing so, the university will further demonstrate its vital role in the continued economic, social, and technological development of society. We have also included some thoughts on how this applies specifically to the field of engineering and how a culture of openness and sharing within the engineering community can help drive societal development.
Advances in the management of craniopharyngioma
Authors: O'steen Lillie , Indelicato Daniel J.
Published: October 2018

Craniopharyngioma is a curable benign tumor, but owing to its intimate relationship to critical structures in the central brain—such as the optic apparatus, pituitary, hypothalamus, intracranial vasculature, brain stem, and temporal lobes—its management introduces the risk of long-term treatment morbidity. Today, the most common treatment approach is conservative subtotal resection followed by radiotherapy, and the goal is to limit long-term toxicity. Many recent advances in the treatment of craniopharyngioma are attributable to improved surgical techniques and radiotherapy technologies.
Recent advances in understanding non-celiac gluten sensitivity
Authors: Barbaro Maria Raffaella , Cremon Cesare , Stanghellini Vincenzo , Barbara Giovanni
Published: October 2018

Non-celiac gluten sensitivity (NCGS) is a condition characterized by intestinal and extra-intestinal symptoms related to the ingestion of gluten-containing foods in the absence of celiac disease and wheat allergy. The diagnosis is cumbersome and currently confirmed only by gluten withdrawal and double-blind placebo challenge protocols. There is great overlap in symptoms between NCGS and other functional gastrointestinal disorders, making a differential diagnosis difficult. The pathophysiology of NCGS is largely unclear, and there are contrasting data on the trigger of this condition. This review will highlight the state-of-the-art knowledge on NCGS and the key open questions.
Effectiveness of triple antibiotic paste as an intra-canal medication for the root canal treatment of non-vital teeth with apical periodontitis: A systematic review
Authors: Abdel Hamid Ehab , Abdel Aziz Saied , Sadek Hany Samy , Ibrahim Ahmed Mohamed
Published: October 2018

Background: This is a systematic review to assess and provide a pooled effect estimate, if possible, for the effects of triple antibiotic paste as an intra-canal medication for root canal treatment of mature permanent non-vital teeth with apical periodontitis. This review will assess post-operative pain, flare-up incidence, and clinical and radiographic healing.

Methods: Nine electronic databases (Pubmed, CENTRAL, VHL, Scopus, EBSCOhost, Web of Science, Trip, OpenGrey, Proquest) were searched along with two major clinical trial registries. Conference proceedings, reference lists and citations of the included studies were also searched. A total of 537 records were identified and 392 were obtained after duplicate removal. Six records were identified after screening and three studies were included after full text eligibility assessment.

Results:  Three comparators were reported in the included studies: calcium hydroxide paste, 2% chlorhexidine gel and ledermix paste.  There was no statistically significant difference between triple antibiotic paste and calcium hydroxide regarding postoperative pain, and clinical and radiographic healing of periapical lesions. There was no difference between triple antibiotic paste and chlorhexidine regarding flare-up incidence. However, triple antibiotic paste reduced the level of post-operative pain more than ledermix, which was statistically significant.

Conclusions:  The evidence is still insufficient surrounding the use of triple antibiotic paste; therefore more clinical investigations with high levels of evidence and rigorous methodologies are needed.
Work with Mathematically Gifted Children in a Multi-Level System of Subject Olympiads and Competitions
Authors: Агаханов Н. , Agahanov N.
Published: October 2018

The article presents a multi-level system of subject Olympiads and competitions in mathematics for the identifi cation and development of mathematically gifted schoolchildren that has developed in Russia at present. The activity of each structural component and their purpose are described. The conceptual bases of work with mathematically gifted children in the multi-level system of subject Olympiads and competitions are revealed: the formation of the intellectual elite; increasing the role of mathematics in modern society; identifi cation, selection and self-realization of gifted children; professional orientation; development and specifi city of tasks for mathematical Olympiads and competitions; coaching support in working with mathematically gifted children; content and stages of work with mathematically gifted children; a variety of forms of additional education for mathematically gifted children; stimulating teachers to work with gifted children; organizational support of education management bodies; popularization of mathematical education.
Derivation and Performance of Standardized Enhanced Liver Fibrosis (ELF) Test Thresholds for the Detection and Prognosis of Liver Fibrosis
Authors: Day James , Patel Preya , Parkes Julie , Rosenberg William
Published: October 2018

Introduction

Noninvasive tests are increasingly used to assess liver fibrosis and determine prognosis but suggested test thresholds vary. We describe the selection of standardized thresholds for the Enhanced Liver Fibrosis (ELF) test for the detection of liver fibrosis and for prognostication in chronic liver disease.

Methods

A Delphi method was used to identify thresholds for the ELF test to predict histological liver fibrosis stages, including cirrhosis, using data derived from 921 patients in the EUROGOLF cohort. These thresholds were then used to determine the prognostic performance of ELF in a subset of 457 patients followed for a mean of 5 years.

Results

The Delphi panel selected sensitivity of 85% for the detection of fibrosis and >95% specificity for cirrhosis. The corresponding thresholds were 7.7, 9.8, and 11.3. Eighty-five percent of patients with mild or worse fibrosis had an ELF score ≥7.7. The sensitivity for cirrhosis of ELF ≥9.8 was 76%. ELF ≥11.3 was 97% specific for cirrhosis. ELF scores show a near-linear relationship with Ishak fibrosis stages. Relative to the <7.7 group, the hazard ratios for a liver-related outcome at 5 years were 21.00 (95% CI, 2.68–164.65) and 71.04 (95% CI, 9.4–536.7) in the 9.8 to <11.3 and ≥11.3 subgroups, respectively.

Conclusion

The selection of standard thresholds for detection and prognosis of liver fibrosis is described and their performance reported. These thresholds should prove useful in both interpreting and explaining test results and when considering the relationship of ELF score to Ishak stage in the context of monitoring.
Extracorporeal Membrane Oxygenation in a 29-Year-Old Man with Pneumocystis jirovecii Respiratory Failure and AIDS
Authors: Hernandez Conte Antonio T. , Ng David , Ramzy Danny , Dilibero Deanna , LaBounty Troy M. , Gaultier Cyril , Behringer Elizabeth C.
Published: October 2018

The use of extracorporeal membrane oxygenation (ECMO) in patients who have acute respiratory distress syndrome has been generally beneficial. However, because of various concerns, ECMO has rarely been used in patients who have human immunodeficiency virus infection with or without acquired immune deficiency syndrome.

We report our successful use of venovenous ECMO in a 29-year-old man who presented with severe respiratory distress secondary to Pneumocystis jirovecii pneumonia associated with undiagnosed infection with the human immunodeficiency virus and acquired immune deficiency syndrome. After highly active antiretroviral therapy was begun, acute immune reconstitution inflammatory syndrome developed. The patient's respiratory condition deteriorated rapidly; he was placed on venovenous ECMO for 19 days and remained intubated thereafter. After a 65-day hospital stay and inpatient pulmonary rehabilitation, he recovered fully. In addition to presenting this case, we review the few previous reports and note the multidisciplinary medical and surgical support necessary to treat similar patients.
Implantable Cardioverter-Defibrillator Placement for Primary Prevention in 2,346 Patients: Predictors of One-Year Survival
Authors: Merchant Faisal M. , Desai Yaanik , Addish Maher A. , Kelly Kimberly , Casey Mary , Goyal Abhinav , Leon Angel R. , El-Chami Mikhael F.
Published: October 2018

Guidelines suggest that patients who receive implantable cardioverter-defibrillators (ICDs) for primary prevention should be expected to live more than one year after placement. However, tools for validating this prognosis are not sufficiently predictive. We sought to identify definitive predictors of one-year survival after ICD placement.

By reviewing medical records and the Social Security Death Index, we analyzed baseline characteristics and survival outcomes of 3,164 patients who underwent ICD placement at our institution from January 2006 through March 2014.

Survival outcome could be confirmed for 2,346 patients (74%). Of these, 184 (7.8%) died within one year of ICD placement. We noted significant differences in numerous variables between those who lived and died. However, multivariable analysis revealed only 5 independent predictors of earlier death: worse New York Heart Association functional class (hazard ratio [HR]=1.87 per class [95% CI, 1.22–2.87]; P <0.01); lower serum sodium level (HR=0.93 per 1 mEq/L increase [95% CI, 0.88–0.99]; P=0.04); atrial fibrillation (HR=1.81 [95% CI, 1.03–3.21]; P=0.04); chronic lung disease (HR=2.05 [95% CI, 1.20–3.51]; P <0.01), and amiodarone use (HR=10.1 [95% CI, 4.51–22.5]; P <0.01). Using receiver operating characteristic curves, we developed a model with an area under the curve of 0.718 that predicted death at one year after ICD implantation.

Despite significant univariate differences between the ICD recipients who did and did not live beyond one year, we found only moderate predictors of survival. Better tools are needed to predict outcomes when considering ICD placement for primary prevention.
Karakterisasi Molekuler Papaya ringspot virus tipe P pada Tanaman Mentimun di Jawa
Authors: Listihani Listihani , Damayanti Tri Asmira , Hidayat Sri Hendrastuti , Wiyono Suryo
Published: October 2018

Moleculer Characterization of Papaya ringspot virus type P on Cucumber in JavaInfection of Papaya ringspot virus (PRSV) on cucumber plants showing mosaic symptom was detected using specific antibody.  Further investigation was conducted to determine molecular characters and status of PRSV infecting cucumber in Java.  Infection of PRSV was detected from leaf samples collected from the field using dot immunobinding assay (DIBA).  Disease frequency caused by PRSV infection reached 81.11%, 95.86%, 91.66%, and 92.3% in East Java, Central Java, Yogyakarta, and West Java, respectively.  Characterization of PRSV isolates was conducted by reverse transcription polymerase chain reaction (RT-PCR) using specific primers for PRSV-P and PRSV-W, followed by cloning, and DNA sequencing.  DNA fragment of 470 bp was successfully amplified using specific primers for PRSV-P from several samples from Nganjuk, Brebes, Kulon Progo, and Subang; but no amplification was achieved using specific primers for PRSV-W.  Nucleotide and amino acid analysis showed high homology among PRSV-P isolates from Nganjuk, Brebes, Kulon Progo, and Subang, i.e. 98.6%-99.7% and 99.3%-100%, respectively.  This is an indication of a low genetic variation among PRSV-P from Java. Further phylogenetic analysis indicated that PRSV-P isolate cucumber is in the same cluster with PRSV-P isolate papaya from Bali, Indonesia.  This is the first report of PRSV-P infecting cucumber in Indonesia.
Reference Styles: Implications of Citation Standards
Authors: . Damini , Kaur Prabhpreet
Published: October 2018

This paper discusses the different referencing styles. Referencing acknowledges the sources of information and ideas that you have used to write your paper and which allows the sources to be identified. This paper focuses on the different types of referencing styles you can use with examples.
Noise Adaptive FCM algorithm for Segmentation of MRI Brain Images
Authors: Singh Harmanpreet , Kaur Ramandeep
Published: October 2018

Image segmentation is an important task in many image processing applications. Fuzzy C means algorithm has been widely used for the segmentation. There are many versions of the traditional FCM algorithm which uses the local spatial information to increase the robustness of this algorithm in presence of noise, but all these algorithms do not
successfully segment the images contaminated by heavy noise. In order to solve this problem, non-local spatial information present in the image is utilized. The filtering parameter ‘h’ in the non-local information is a crucial parameter which needs to be appropriately determined, irrespective of using a single constant value of ‘h’; we can determine its value using the standard deviation of noise present in the image. The adaptive non-local information
determined is termed as noise adaptive non-local spatial information. This adaptive non-local information is used in the FCM algorithm for the segmentation of MRI images. In this paper Noise adaptive FCM algorithm (NAFCM) using adaptive non-local information is proposed. Therefore the proposed algorithm utilizes adaptive non-local information making it robust in presence of noise as well as preserving the details present in the image. The efficiency of the proposed algorithm is demonstrated by validation studies on synthetic as well as simulated brain MRI images.
The results of the proposed algorithm show that the proposed algorithm is robust to noise and as compared to other state of the art algorithms.
Perioperative insulin therapy
Authors: Leurcharusmee Prangmalee , Kositratna Guy , Tran De Q. , Schricker Thomas
Published: October 2018

Surgical patients commonly develop hyperglycemia secondary to the neuroendocrine stress response. Insulin treatment of hyperglycemia is required to overcome the perioperative catabolic state and acute insulin resistance. Besides its metabolic actions on glucose metabolism, insulin also displays nonmetabolic physiological effects. Preoperative glycemic assessment, maintenance of normoglycemia, and avoidance of glucose variability are paramount to optimize surgical outcomes. This review discusses the basic physiology and effects of insulin as well as practical issues pertaining to its management during the perioperative period.
Antimicrobial activity of some novel 2-(2-iodophenylimino)-5-arylidenethiazolidin-4-one derivatives
Authors: Pham Duy Toan , Vo Thi My Huong , Truong Phuong , Ho Phuoc Tinh , Nguyen Manh Quan
Published: October 2018

Background

Infectious diseases, especially those caused by multidrug-resistant bacteria, are becoming a serious problem worldwide because of the lack of effective therapeutic agents. Moreover, most antifungal drugs exhibit low efficacy and high toxicity because of the similarity between fungal and human cells. These issues warrant the search for potential new agents.

Objectives

To synthesize potent 2-(2-iodophenylimino)-5-arylidenethiazolidin-4-one derivatives, improve the synthetic process, elucidate their structures, and determine their antimicrobial activity.

Methods

2-Iodoaniline was used as an initial reactant in a 3-step process for the synthesis of 2-(2-iodophenylimino)-5-arylidenethiazolidin-4-one derivatives, including an acylation reaction, a cyclization reaction, and aldol condensation reactions. The structures of the obtained derivatives were investigated and elucidated using spectral methods. Antimicrobial activity toward 5 bacterial strains and 2 fungal strains was determined using Kirby–Bauer and agar dilution methods.

Results

We successfully synthesized 12 novel compounds and elucidated their structures. The derivatives had no antifungal activities. By contrast, they showed remarkable antibacterial activities. Some of them with minimum inhibitory concentrations (MICs) ≤8 μg/mL in both Staphylococcus aureus and methicillin-resistant S. aureus.

Conclusions

A simple and flexible way to synthesize new compounds with a thiazolidin-4-one ring was determined. Some of these new compounds have outstanding effects with low MICs for bacteria. Their further investigation as therapeutic agents is warranted.
Autoimmune hemolytic anemia and autoantibodies in a patient with Plasmodium falciparum infection: report of a rare case and review of the literature
Authors: Chamnanchanunt Supat , Thungthong Pravinwan , Kudsood Sirvicha , Somwong Waraporn , Hirunmassuwan Manassamon
Published: October 2018

Background

Anemia is a common problem among patients with malaria infection, which induces hemolysis during treatment. A few patients present with autoimmune hemolytic anemia (AIHA) and autoantibodies, such as autoanti-E and autoanti-I, during malaria infection.

Objective

To report the clinical response of a patient with Plasmodium falciparum malaria infection with a hemolytic condition.

Methods

We reviewed medical records of a patient with P. falciparum malaria and related literature.

Results

Our patient presented with P. falciparum malaria infection and received artesunate and ceftriaxone to cover potential tropical infectious diseases. After malaria parasite was eradicated, her hemoglobin declined, and AIHA and autoantibodies were found, explaining the cause of anemia. Corticosteroid was given at a standard dosage, and her hemoglobin became normal within 1 week.

Conclusion

Patients with falciparum malaria and both AIHA and autoantibody complications are rare. Our patient responded to malaria eradication and corticosteroid treatment. Most cases reported seem to respond to corticosteroid with a variety of recovery times. However, corticosteroids might increase the severity of infection; more clinical data to support a standard regimen to treat properly rare hematologic complications (AIHA and autoantibodies) in malaria patients are warranted.
Moving average quality control: principles, practical application and future perspectives
Authors: van Rossum Huub H.
Published: October 2018

Moving average quality control (MA QC) was described decades ago as an analytical quality control instrument. Although a potentially valuable tool, it is struggling to meet expectations due to its complexity and need for evidence-based guidance. For this review, relevant literature and the world wide web were examined in order to (i) explain the basic concepts and current understanding of MA QC, (ii) discuss moving average (MA) optimization methods, (iii) gain insight into practical aspects related to applying MA in daily practice and (iv) describe future prospects to enable more widespread acceptance and application of MA QC. Each of the MA QC optimization methods currently available has their own advantages and disadvantages. Recently developed simulation methods provide realistic error detecting properties for MA QC and are available for laboratories. Operational MA management issues have been identified that allow developers of MA software to upgrade their packages to support optimal MA QC application and guide laboratories on MA management issues, such as MA alarm workup. The new insights into MA QC characteristics and operational issues, together with supporting online tools, may promote more widespread acceptance and application of MA QC.
Two general schemes of algebraic cryptography
Authors: Roman’kov Vitaly
Published: October 2018

In this paper, we introduce two general schemes of algebraic cryptography. We show that many of the systems and protocols considered in literature that use two-sided multiplications are specific cases of the first general scheme. In a similar way, we introduce the second general scheme that joins systems and protocols based on automorphisms or endomorphisms of algebraic systems. Also, we discuss possible applications of the membership search problem in algebraic cryptanalysis. We show how an efficient decidability of the underlined membership search problem for an algebraic system chosen as the platform can be applied to show a vulnerability of both schemes. Our attacks are based on the linear or on the nonlinear decomposition method, which complete each other. We give a couple of examples of systems and protocols known in the literature that use one of the two introduced schemes with their cryptanalysis. Mostly, these protocols simulate classical cryptographic schemes, such as Diffie–Hellman, Massey–Omura and ElGamal in algebraic setting. Furthermore, we show that, in many cases, one can break the schemes without solving the algorithmic problems on which the assumptions are based.
Maximal subgroups of the modular and other groups
Authors: Jones Gareth A.
Published: October 2018

In 1933 B. H. Neumann constructed uncountably many subgroups of

SL
2

⁢

(
ℤ
)

{{\rm SL}_{2}(\mathbb{Z})}

which act regularly on the primitive elements of

ℤ
2

{\mathbb{Z}^{2}}

. As pointed out by Magnus, their images in the modular group

PSL
2

⁢

(
ℤ
)

≅

C
3

*

C
2

{{\rm PSL}_{2}(\mathbb{Z})\cong C_{3}*C_{2}}

are maximal nonparabolic subgroups, that is, maximal with respect to containing no parabolic elements.
We strengthen and extend this result by giving a simple construction using planar maps to show that for all integers

p
≥
3

{p\geq 3}

,

q
≥
2

{q\geq 2}

the triangle group

Γ
=

Δ
⁢

(
p
,
q
,
∞
)

≅

C
p

*

C
q

{\Gamma=\Delta(p,q,\infty)\cong C_{p}*C_{q}}

has uncountably many conjugacy classes of nonparabolic maximal subgroups. We also extend results of Tretkoff and of Brenner and Lyndon for the modular group by constructing uncountably many conjugacy classes of such subgroups of Γ which do not arise from Neumann’s original method. These maximal subgroups are all generated by elliptic elements, of finite order, but a similar construction yields uncountably many conjugacy classes of torsion-free maximal subgroups of the Hecke groups

C
p

*

C
2

{C_{p}*C_{2}}

for odd

p
≥
3

{p\geq 3}

. Finally, an adaptation of work of Conder yields uncountably many conjugacy classes of maximal subgroups of

Δ
⁢

(
2
,
3
,
r
)

{\Delta(2,3,r)}

for all

r
≥
7

{r\geq 7}

.
Crystal structure of (bis((1H-benzo[d]imidazol2-yl)methyl)amine-κ3N,N′,N′′)-(pyridine-2,6-dicarboxylato-κ3N,O,O′)zinc(II) — methanol — water (1/2/1), C25H28N6O7Zn
Authors: Gu Jin-Feng , Feng Rui , Nie Feng-Mei
Published: October 2018

C25H28N6O7Zn, triclinic,P1̄ (no. 2),a= 7.8073(19) Å,b= 11.350(3) Å,c= 15.515(4) Å,α= 95.006(2)°,β= 101.828(3)°,γ= 102.050(4)°,V= 1303.8(5) Å3,Z= 2,Rgt(F) = 0.0429,wRref(F2) = 0.1153,T= 153(2) K.
Das Politische als Entpolitisierung der Politik
Authors: Hirsch Michael
Published: October 2018

Die in der politischen Theorie der Gegenwart inzwischen übliche Unterscheidung ‚des Politischen’ von der Politik im Sinne staatlicher Institutionen und Verwaltungsapparate wird in diesem Beitrag einer systematischen Kritik unterzogen. Dabei benutzt der Autor zunächst ein verfallstheoretisches normatives Schema des Linkantianismus. Es wird argumentiert, dass die analytische Aufspaltung zwischen einem ‚sachlichen’ Bereichs der Politik als staatliche Verwaltung gesellschaftlicher Teile und einem ‚sozialen’ Bereich der Instituierung der Gemeinschaft sich affirmativ verhält zu den faktischen Prozessen einer zunehmenden rechtlichen Entfesselung staatlichen Handelns aus demokratischer Kontrolle. Dem wird ein emphatisch aufklärerisches Paradigma radikaler Demokratie entgegengesetzt.
Die Destruktion der Gesellschaftstheorie: Ernesto Laclaus und Chantal Mouffes Versuch einer nicht-essentialistischen Politischen Philosophie
Authors: Kistner André
Published: October 2018

Das Buch Hegemony and Socialist Strategy ist von entscheidender Wichtigkeit, wenn man die Wende linker Theorieproduktion zum Postmodernismus verstehen will. Sie weisen dort die These des klassischen Marxismus, dass die objektive gesellschaftliche Entwicklung auf eine politische Veränderung der Gesellschaft zum Sozialismus hindränge, unter Bezugnahme auf eine linguistisch inspirierte Theorie des Politischen im Allgemeinen zurück. In diesem Zusammenhang eliminieren sie jedoch zugleich den Begriff der Gesellschaft als Gegenstand theoretischer Analyse und Kritik. An dessen Stelle tritt die Vielfalt der politischen Kämpfe um Hegemonie, die aber theoretisch weder begriffen noch bewertet werden können. Insofern ist der postmoderne Antiökonomismus Teil der modernen demokratischen Legitimationsideologie und von geringem theoretischen Wert.
Politischer Marxismus contra Postmarxismus
Authors: Wallat Hendrik
Published: October 2018

Ellen M. Wood hat mit ihrer Studie „Retreat from Class. A ‚new true socialism“ bereits 1986 eine überzeugende Kritik des Postmarxismus vorgelegt. Der Artikel zeichnet deren zentrale Punkte nach und zeigt, dass diese auf einer innovativen Interpretation des historischen Materialismus beruhen, die als ‚politischer Marxismus‘ bezeichnet wird. Gleichwohl bleibt zu fragen, ob Woods Kritik nicht zugleich Annahmen des klassischen Marxismus reproduziert, die historisch wie systematisch zweifelhaft sind.
Die „letzte Sinnlosigkeit“
Authors: Rickermann Jan
Published: October 2018

Erkannte der politische Existentialismus Schmitts noch in der Ausnahme das Lebendige gegenüber der in Wiederholung erstarrten Mechanik des Rechtsstaates, ist diese in Agambens Analyse der Souveränität längst zur Regel geworden. Sie schließt, als nicht abgeschlossener konstituierender Akt, durch Ausschluss, das Leben in das Recht ein. Politik wird damit zu einer fatalen Logik, die das nackte Leben absondert und letztlich der Vernichtung überantwortet. Die Suche nach einer Alternative, nach einer kommenden Politik, führt zur Figur des durch Ausschluss eingeschlossenen, zum homo sacer. An ihm wird die Möglichkeit des Widerstands festgemacht. Ausgehend vom homo sacer findet Agamben die Möglichkeit einer kommenden Politik in der Lebens-Form, einem Dasein, auf das die Macht keinen Zugriff mehr hat.
Brazilian Labour Reform in Historical Perspective
Authors: Oliveira Roberto Véras de
Published: October 2018

This article presents a historical perspective on the foundations of labour market regulation in Brazil. It aims to provide a better understanding of the “modernising” initiatives that have been presented since the 1990s and that have recently gained new contours with the approval of the Labour Reform, in July 2017, and other similar measures. This is particularly important because Brazil is currently suffering deep economic stagnation and a severe political crisis, after a period of significant economic growth. It draws on both classical and current studies by labour sociologists and economists, as well as on the author’s previous studies.
The General Criteria for Personality Disorders Assessed by Interview: Do They Still Have a Role to Play?
Authors: Peri Josep M. , Muñoz-Champel Ana , Torrubia Rafael , Gutiérrez Fernando
Published: October 2018

On the path to developing dimensional models of personality disorder (PD), we are at risk of leaving key diagnostic aspects behind. The general criteria for PD may be important ones because they reflect the defining aspects of personality pathology: long duration, independence from psychopathological states, and harmfulness. We assessed these criteria by interview in a sample of 362 psychiatric outpatients after administering the Personality Diagnostic Questionnaire–4+. The result was a 42.5% fall in self-reported endorsements, due to misinterpretations (11.5%), short duration of traits or contamination by state psychopathology (9.8%), and traits being non-harmful (21.2%). However, not all personality traits and disorders underwent correction to the same extent, and ultimately, the interview did not improve the prediction of clinical variables. These findings raise doubts about the practical relevance of the general criteria for PD and support the role of self-report questionnaires for diagnostic purposes.
Multisite Implementation and Evaluation of 12-Month Standard Dialectical Behavior Therapy in a Public Community Setting
Authors: Flynn Daniel , Kells Mary , Joyce Mary , Corcoran Paul , Hurley Justina , Gillespie Conall , Suarez Catalina , Swales Michaela , Arensman Ella
Published: October 2018

Dialectical behavior therapy (DBT) is an effective intervention for treating adults with emotional and behavioral dysregulation. The National DBT Project, Ireland was established in 2013 to coordinate the implementation of DBT across public community mental health settings at a national level. This study describes the implementation and evaluation of DBT across multiple independent sites in adult mental health services (AMHS). The Consolidated Framework for Implementation Research was used to guide this national implementation where barriers and facilitators to DBT implementation were considered. Nine AMHS teams completed DBT training and delivered the standard 12-month program. One hundred and ninety-six adults with borderline personality disorder participated in the program, and outcome measures were recorded at four time points. Significant reductions on outcome measures, including frequency of self-harm and suicidal ideation, were observed. This study highlights that DBT can be successfully implemented in community mental health settings as part of a coordinated implementation.
Paczka wiary, nóż nauki i kurz zwątpienia. Filozoficzno-literacki midrasz o dialogu nauka–filozofia–teologia
Authors: Sierotowicz Tadeusz
Published: October 2018

W oparciu o osiągnięcia filozofii nauki i niektóre aspekty filozofii Józefa Tischnera esej rozwija literacko-filozoficzny model dialogu nauka–filozofia–teologia. Refleksja prowadząca do sformułowania modelu pozwala na inne spojrzenie na historię dysput nauka–wiara: podstawową kwestią dialogu staje się określenie dziedziny, w której możliwe jest rozwiązanie danego sformułowania problemu.
FROM “JIBARA” TO “CHIQUITA”: CONFESSIONS OF DIS-BELONGING IN ESMERALDA SANTIAGO’S MEMOIRS
Authors: ÇOKER Esra
Published: October 2018

This paper by focusing on the intersection
of race, gender and identity as reflected in the three memoirs of the
Puerto-Rican American writer Esmeralda Santiago, When I was Puerto Rican (1993),
Almost a Woman (1998) and The Turkish Lover (2004), attempts to read into the
complex dynamics of the Puerto-Rican migrant female experience. Esmeralda
Santiago’s memoirs that intertwine the problem of transculturation with that of
male dominance and cultural patriarchy rest on her desire to find and sustain a
stable point of reference in a world marked by mobility, transitivity,
discontinuity and fragmentation. The feelings of vulnerability and invisibility
that she constantly experiences within her Puerto-Rican culture and later with
her Turkish lover lead her to resist rather than accept a gendered and
racialized self. However it also leads her to forge an identity “distinct from”
and “in conflict with” the significant Others around her.  In When I was Puerto Rican, she is the black
jibara “Negi” highly critical and at odds with her Puerto/AmeRican island
heritage; in Almost A Woman, she is the lost young female Esmeralda trying to
rise above her mother, family and Nuyorican community; and in the The Turkish
Lover she is the Esmeralda Santiago who learns to judge her own self and others
through the social and racial categories and cultural standards of American
society. This paper asserts that unlike many women autobiographical writers,
Esmeralda Santiago can achieve to create a sense of belonging in her life only
through an assertion of difference and later through the contestation of her
Puerto-Rican female identity.
Characterization of 3 fluoro-4-formylphenylboronic acid molecule with Density Functional Teory
Authors: BABUR ŞAŞ Emine , KURT Mustafa
Published: October 2018

The geometric structure of
3-fluoro-4-fomylphenylboronic acid (3-4FPBA) molecule were investigated with
DFT/B3LYP/6-311++G(d,p) basis set. Specra of the title molecule were observed
by FT-IR and FT-Raman spectra. Theoretical wavenumber were calculated also the
same metot and compared experimental wavenumber (FT-IR and FT-Raman) which were
in a good agreement with observed ones. Furthermore, electronic structure
properties of in the title molecule such as HOMO-LUMO, Molecular Electrostatic
Potantial (MEP) and Mulliken charges were investigated by TD-DFT method.
AW(k)-type Salkowski Curves in Euclidean 3-Space IE^3
Authors: KİŞİ İlim
Published: October 2018

We deal with AW(k)-type  Salkowski
(anti-Salkowski) curves with constant   in the Euclidean
3-space. We show that there is no AW(1)-type Salkowski curve and AW(1)-type
anti-Salkowski curve in . Also, we handle weak AW(2)-type and weak AW(3)-type
Salkowski (anti-Salkowski) curves. Also, we show that there is no weak AW(2)-type
Salkowski curve in .
IMPACT OF PREDICTIVE ANALYTICS ON THE ACTIVITIES OF COMPANIES
Authors: Khasanov A. R.
Published: October 2018

To analyze the impact of predictive analytics on the activities of companies the research was conducted. Subject information: analytics, diagnostics, predicative analytics. The main tools of predictive analytics and solutions in the market of technical solutions are considered. Thanks to the tools of predictive analytics, companies can analyze and predict the processes that occur in time, identify trends, anticipate changes and, for example, plan future more effectively.
THE REACTION OF INDUSTRIAL COMPANIES TO CRISIS: CHANGES IN BUSINESS-MODEL AND STRATEGIC SUSTAINABILITY
Authors: Stepanyan A. V.
Published: October 2018

Nowadays the changes in the geopolitical situation significantly affect the conditions for doing business in Russia. The article reviews the peculiarities of the development of Russian industrial companies and the subsidiaries of foreign companies, operating in Russia, in difficult economic conditions. The contemporary consequences of global financial crisis of 2008 with respect to the industrial sector of the economy are also reviewed. The author performed an empirical study of the question of whether the companies' sustainable survival in 2014–2016 was affected by the change in the business model and whether these changes were caused by the experience of the previous crisis. The study considered the differences in the behavior of foreign and Russian companies, and the strategies, that reduce the risk of default, are defined.
Damages of locomotor apparatus in children as a result of road accidents
Authors: Belokrylov N. M. , Ladeischikov V. M. , Schekolova N. B. , Belyakov S. A. , Belokrylov A. N. , Yagovkin M. A.
Published: October 2018

Aim. To study the specific features of locomotor apparatus injuries and to improve the surgical tactics of treatment using low invasive osteosynthesis techniques in case of road accidents among children.

Materials and methods. The results of surgical treatment of 35 children (age range 2 to14 years) after road accidents were studied at the pediatric traumatology and orthopedics unit. Associated multisystem injuries of the locomotor system constituted 77,1 %. Clinicoroentgenological data, MRT and CT indices were studied. Vegetative dysfunction was assessed. All the patients underwent low invasive surgical intervention with minimized surgical approach, including elastic intramedullary nails, closed transcutaneous pin osteosynthesis under electro-optic transducer control, transosseous osteosynthesis.

Results. All the patients were operated, 80 % of them were operated during the first day after the admission to the hospital. It resulted in early arrest of pain syndrome, fast normalization of vegetative function, prevented the development of traumatic disease or stopped its manifestations. All the results of surgical treatment were estimated as positive. Insignificant contractures were observed in 2 patients after the distal comminuted fracture of the shoulder with decrease in movement amplitude at the level of elbow joint within 15%; no disability was noted; no slowed consolidation and false joints were registered.

Conclusions. Low invasive techniques provide optimal conditions for osseous consolidation and positive functional outcome after road accidents. It is recommended to take into account the status of vegetative functions in patients with associated multisystem injuries.
Analysis of follow-up observation efficiency criteria
Authors: Sandakov Ya. P.
Published: October 2018

Aim. To carry out the comparative analysis of follow-up observation efficiency criteria among patients under medical check-up and persons, who had been followed up from the number of those, dead at home.

Material and methods. The age, duration of disease, duration of follow-up observation, real visits to a doctor, rate of exacerbations, emergency calls, hospitalizations were compared in two groups of patients under medical check-up. Group 1 – “dead” – included 100 persons from the number of those, dead at home; group 2 – “alive” – 400 patients, who at the moment of being studied were under follow-up observation. Medical records of ambulatory patients were used as the source of information. The obtained data were analyzed with the method of descriptive and inductive statistics.

Results. In the studied groups, the difference in patients’ mean age was significant t = 3,7 p = 0,0001, the share of persons of the same gender was similar p < 0,01, the difference in men’s mean age was not significant t = –0,21 p = 0,83. The average number of planned (t = 14,2 p = 0,0001) and real (t = 7,4 p = 0,0001) visits to a doctor, exacerbations (t = 9,6 p = 0,0001), emergency calls (t = 7,6 p = 0,0001), hospitalizations (t = 5,2 p = 0,0001), urgent hospitalizations (t = 6,6 p = 0,0001) was significantly higher in the group of “dead”.

Conclusions. The able-bodied men form the risk group regarding unfavorable outcome of noninfectious chronic diseases; follow-up observation does not promote development of loyalty to treatment.
Syntax, Prosody, Discourse and Information Structure: The case for Unipartite clauses — A View from Spoken Israeli Hebrew / Sintaxe, prosódia, discurso e estrutura informacional: o caso das orações unipartidas. Uma visão do hebraico falado em Israel
Authors: Izre'el Shlomo
Published: October 2018

Abstract: The canonical view of clause requires that it include predication. Utterances that do not fit into this view because they lack a subject are usually regarded as elliptical or as non-sentential utterances. Adopting an integrative approach to the analysis of spoken language that includes syntax, prosody, discourse structure, and information structure, it is suggested that the only necessary and sufficient component constituting a clause is a predicate domain, carrying the informational load of the clause within the discourse context, including a “new” element in the discourse, carrying modality, and focused. Utterances that have not been hitherto analyzed as consisting of full clauses or sentences will be reevaluated. The utterance, being a discourse unit defined by prosodic boundaries, can thus be viewed as the default domain of a clause or a sentence, when the latter are determined according to the suggested integrative approach.Keywords: syntax; clause structure; information structure; discourse; context; prosody; utterance; history of linguistics; spoken Israeli Hebrew.Resumo: A posição canônica sobre as orações requer que elas contenham uma predição. Enunciados que não se encaixem nessa visão porque não possuem um sujeito são usualmente considerados elípticos ou como enunciados não-oracionais. Adotando uma visão integrativa para a análise da língua falada, que inclui a sintaxe, a prosódia, a estrutura discursiva e a estrutura informacional, sugere-se que o único componente constituinte necessário e suficiente para uma oração é um domínio predicativo, o qual carregue a carga informacional da oração no contexto do discurso, incluindo-se um “novo” elemento no discurso, que carregue modalidade e foco. Enunciados que até então foram classificados como não sendo orações ou sentenças completas serão reavaliados. O enunciado, sendo uma unidade discursiva definida por fronteiras prosódicas, pode assim ser visto como o domínio de uma oração ou sentença por excelência, quando estas são determinadas através da abordagem integrativa sugerida.Palavras-chave: sintaxe; estrutura oracional; estrutura informacional; discurso; contexto; prosódia; enunciado; história da Linguística; hebraico israelense falado.
Helicobacter pylori CagA IgG pozitifliğinin gastrointestinal yakınmalar ve histopatolojik bulgular ile ilişkisi
Authors: BAKIRCI ÜREYEN Sibel , EFE Cumali , NASIROĞLU İMGA Narin , KÖSEOĞLU Tankut , ÖZASLAN Ersan , TUNCA Hasan , SENNAROĞLU Engin
Published: October 2018

Giriş ve Amaç: Güçlü immünojen ve sitotoksin olan Helicobacter

pylori CagA

dış membran proteinine karşı

oluşan IgG tipi antikorların tespitine dayanarak yapılan serolojik testlerin,

bu mikroorganizmaların neden olduğu patolojilerin tespitinde kullanımı son

yıllarda yaygınlaşmaktadır. Bu çalışmada, Helicobacter

pylori’ye karşı oluşmuş

CagA IgG antikorlarının gastrointestinal yakınmalar, histopatolojik ve demografik

veriler ile ilişkisinin

değerlendirilmesi amaçlandı. Gereç ve Yöntem: Farklı gastrointestinal yakınmalar ile

dahiliye polikliniğine başvurduktan sonra rutin değerlendirmelerinde üre nefes

testi ile Helicobacter pylori açısından pozitif olarak tespit edildikten sonra tanı amaçlı özofagogastroduodenoskopik biyopsi yapılan18

yaş üzeri toplam 74 hasta çalışmamıza dahil edildi. Bu hastalarda CagA proteinine ait özgül IgG antikor varlığını saptamak için Enzyme Linked Immunosorbent Assay yöntemi

kullanıldı. Bulgular: Yetmişdört hastanın 20’si kadın (%27) ve 54’ü erkekti (%73). Helicobacter pylori pozitif saptanan

hastaların %62’sinde CagA IgG pozitifliği saptandı. CagA

IgG pozitif hasta

grubunda en sık saptanan gastrointestinal şikayet karın ağrısı ve en sık

histopatolojik bulgu kronik aktif gastrit olarak tespit edildi. Sonuç: Helicobacter pylori enfeksiyonu

ile ilişkili patolojilerin erken tanısında daha

ucuz, pratik ve invaziv olmayan bu serolojik

testlerin kullanımının standardize edilmesi için uzun dönemli ve büyük örneklem

büyüklüğüne sahip çalışmaların yapılmasına ihtiyaç vardır.