bluuebunny/crossref_metadata_2025 huggingface dataset:
Designing narrative for professional development: A programme for improving international health care practitioners’ cultural competence
Authors: Short Alison
Published: October 2022

To maintain and improve skills for practice, health care professionals across all disciplines need to engage in ongoing professional development. However, helping clinicians learn and apply new knowledge in practice can be challenging. This article reports on a purpose-designed professional development programme targeting experienced practitioners of a particular music therapy, focusing on their cultural competency. The author conceptualised a workshop format with a relevant clinical scenario at its centre. She describes how she developed the programme, which she subsequently delivered to an international community of 57 practitioners attending professional development conferences. To capture participants’ reactions and evidence of their new thinking applied to an everyday clinical practice, she used Brookfield’s Critical Incident Questionnaire (CIQ). Her analysis of the data, which provided feedback on the training scenario and structured group discussion materials, found that this continuing professional development training workshop was effective in challenging clinicians to think differently, and to plan the application of their newly acquired knowledge to their everyday practice. This paradigmatic case study contributes new knowledge towards the current reform of health systems, where achieving person-centred health care depends on the ongoing professional development of established health practitioners. Replacing traditional health care, where the patient receiving treatment is accorded a passive role, person-centred health care engages patients’ active participation in their therapy. Practitioners who have graduated a while ago therefore need to change some of their ingrained practices and approaches in treating their clients and patients, which will then lead to improved health outcomes.
An Agrobacterium strain auxotrophic for methionine is useful for switchgrass transformation
Authors: Prías-Blanco Mónica , Chappell Timothy M. , Freed Emily F. , Illa-Berenguer Eudald , Eckert Carrie A. , Parrott Wayne A.
Published: October 2022

Auxotrophic strains of Agrobacterium tumefaciens can contribute to the development of more efficient transformation systems, especially for crops historically considered recalcitrant. Homologous recombination was used to derive methionine auxotrophs of two common A. tumefaciens strains, LBA4404 and EHA105. The EHA105 strains were more efficient for switchgrass transformation, while both the EHA105 and LBA4404 strains worked equally well for the rice control. Event quality, as measured by transgene copy number, was not affected by auxotrophy, but was higher for the LBA4404 strains than the EHA105 strains. Ultimately, the use of auxotrophs reduced bacterial overgrowth during co-cultivation and decreased the need for antibiotics.
Global Sensitivity Analysis of a Coupled Hydro-Economic Model and Groundwater Restriction Assessment
Authors: Rodríguez-Flores José M. , Valero Fandiño Jorge A. , Cole Spencer A. , Malek Keyvan , Karimi Tina , Zeff Harrison B. , Reed Patrick M. , Escriva-Bou Alvar , Medellín-Azuara Josué
Published: October 2022

Assessing impacts on coupled food-water systems that may emerge from water policies, changes in economic drivers and crop productivity requires an understanding of dominant uncertainties. This paper assesses how a candidate groundwater pumping restriction and crop prices, crop yields, surface water price, electricity price, and parametric uncertainties shape economic and groundwater performance metrics from a coupled hydro-economic model (HEM) through a diagnostic global sensitivity analysis (GSA). The HEM used in this study integrates a groundwater depth response, modeled by an Artificial Neural Network (ANN), into a calibrated Positive Mathematical Programming (PMP) agricultural production model. Results show that in addition to a groundwater pumping restriction, performance metrics are highly sensitive to prices and yields of perennial tree crops. These sensitivities become salient during dry years when there is a higher reliance on groundwater. Furthermore, results indicate that performing a GSA for two different water baseline conditions used to calibrate the production model, dry and wet, result in different sensitivity indices magnitudes and factor prioritization. Diagnostic GSA results are used to understand key factors that affect the performance of a groundwater pumping restriction policy. This research is applied to the Wheeler Ridge-Maricopa Water Storage District located in Kern County, California, region reliant on groundwater and vulnerable to surface water shortages.
NMR-based metabolic profiling of children with premature adrenarche
Authors: Matzarapi Konstantina , Giannakopoulos Aristeidis , Chasapi Styliani A. , Kritikou Dimitra , Efthymiadou Alexandra , Chrysis Dionisios , Spyroulias Georgios A.
Published: October 2022

Introduction

Premature adrenarche (PA) for long time was considered a benign condition but later has been connected to various diseases in childhood and adulthood which remains controversial.

Objective

To investigate the effect of premature adrenarche on the metabolic phenotype, and correlate the clinical and biochemical data with the metabolic profile of children with PA.

Methods

Nuclear magnetic resonance (NMR)-based untargeted and targeted metabolomic approach in combination with multivariate and univariate statistical analysis applied to study the metabolic profiles of children with PA. Plasma, serum, and urine samples were collected from fifty-two children with Idiopathic PA and forty-eight age-matched controls from the division of Pediatric Endocrinology of the University Hospital of Patras were enrolled.

Results

Metabolomic results showed that plasma and serum glucose, myo-inositol, amino acids, a population of unsaturated lipids, and esterified cholesterol were higher and significantly different in PA children. In the metabolic profiles of children with PA and age-matched control group a gradual increase of glucose and myo-inositol levels was observed in serum and plasma, which was positively correlated their body mass index standard deviation score (BMI SDS) values respectively. Urine 1H NMR metabolic fingerprint of PA children showed positive correlation and a clustering-dependent relationship with their BMI and bone age (BA) respectively.

Conclusion

This study provides evidence that PA driven metabolic changes begin during the childhood and PA may has an inductive role in a BMI–driven increase of specific metabolites. Finally, urine may be considered as the best biofluid for identification of the PA metabolism as it reflects more clearly the PA metabolic fingerprint.
Pandemie und Wertewandel?
Authors: Eder Anja , Aschauer Wolfgang , Höllinger Franz , Ulrich Martin
Published: October 2022

Soziologische Zeitdiagnosen suggerieren, dass tiefgreifende gesellschaftliche Krisen wie die COVID-19-Pandemie unsere Wertorientierungen infrage stellen und auch relativ kurzfristig ändern könn(t)en. Von dieser Beobachtung ausgehend, wird untersucht, ob es in Österreich im Zeitraum Mai 2020 bis März/April 2021 zu signifikanten Verschiebungen von Wertprioritäten nach der Skala von Shalom Schwartz kam. Als Datenmaterial dienen die beiden ersten Wellen der Panelstudie Values in Crisis. Für die Interpretation der Ergebnisse sind zwei theoretische Annahmen zentral: erstens die These eines zunehmenden Konservatismus und zweitens die These der Wirkmacht politischer Diskurse in Zeiten des (wieder)aufkeimenden Populismus. Besondere Berücksichtigung findet im Beitrag zudem eine methodologische Auseinandersetzung mit dem Wandel der Bedeutung von Fragebogenitems aufgrund der COVID-19-Pandemie.

Die empirischen Analysen bestätigen – entgegen einigen aktuellen Zeitdiagnosen – eine deutliche Stabilität von Wertorientierungen. Verändert hat sich vor allem der Wert der Konformität, indem er für einen Teil der Bevölkerung wichtiger wurde; gleichzeitig verlor der Wunsch nach einer hedonistischen Lebensweise etwas an Bedeutung. Konformität wurde insbesondere für die Wähler*innen der Regierungsparteien wichtiger, während sich dieser Trend vor allem bei den Wähler*innen der FPÖ nicht zeigte. Da die beobachteten Verschiebungen von Wertprioritäten vor allem „pandemie-sensible“ Wertedimensionen betreffen, lässt sich auf der Basis der vorliegenden Ergebnisse insgesamt eher von einer kurzfristigen Reaktion auf die Krise und weniger von einem längerfristigen Wertewandel ausgehen.
Evidence of D-shaped wounds in the intrasomatic bullet path: two case reports
Authors: Tomassini Luca , Manta Anna Maria , Paolini Daniele , Petrasso Pia Eugenia Ylenia , Piras Gianluca Niccolò , Ciallella Costantino
Published: October 2022

The final appearance of gunshot wounds is influenced by both the projectile’s behavior from the muzzle to the terminal target and by the intrinsic characteristics of the anatomical compartments where the lesion(s) occur. The D-shaped morphology is an uncommon yet well-known finding in the forensic literature and has been described when the surface of impact with the skin is represented by the bullet’s lateral projection. Two cases where D-shaped gunshot wounds were observed are hereby presented: in both cases, interaction with multiple intermediate targets (case 1) and a human intermediate target (case 2) had been documented and confirmed by the forensic examination. Despite the different dynamics of production, this peculiar morphology was described throughout most of the intrasomatic bullet path in both the victims. The discovery of D-shaped gunshot wounds can guide the forensic pathologist in the ballistic reconstruction of the event by supporting the hypothesis of an interaction with an intermediate target that has led to deviation from the initial trajectory and destabilization of the bullet associated with loss of kinetic energy.
A fatal and unusual genital mutilation in an elderly man as a result of sharp force injuries and domestic dog predation
Authors: Simonit Francesco , Moreschi Carlo , Desinan Lorenzo
Published: October 2022

Cases of genital amputation require a careful investigation, since they may be the result of self-inflicted injuries, assaults, animal predation, or post-mortem body mutilation. In the present case, an 81-year-old man affected by liver cirrhosis and dementia and suffering from sexual disinhibition was found lying half-naked and unconscious in his courtyard; profuse bleeding in the perineal area and the absence of the external genitalia were observed. The victim was transferred to hospital and underwent surgical emergency treatment, but he died 2 days later. No sharp tools were found on the scene. Moreover, the autopsy did not reveal any defense or tentative wound on the body and no blood stains on the hands of the victim. Several linear scratches were detected close to the edges of the wound; according to the surgical report, these scratches were clean-cut in the lower part and crenated and infiltrated by blood in the cranial part. Although the medical history of the man could be consistent with self-mutilation, it was not possible to rule out the involvement of other people, including the possibility of an attempt by his relatives to cover up what may have been a self-amputation. Furthermore, the victim’s dog vomited parts of the man’s genitalia while being transported to a dog shelter. Similar cases have rarely been published in the current forensic literature.
Importance of Arterial Vessel Length for Metastatic Lymph Node Retrieval and Survival in Standardized Left- and Right-Sided Colon Cancer Surgery
Authors: Tiselius Catarina , Kindler Csaba , Smedh Kenneth
Published: October 2022

Background

We investigated the localization of lymph node metastases, and the role of arterial vessel and specimen lengths in left- and right-sided colon cancer surgery, for survival.

Methods

This was a prospective cross-sectional population-based study of specimens from patients who underwent standardized surgical resection for colon cancer in 2012–2015. The mesocolon of the specimens was divided into four sections for pathological analysis of lymph nodes. Multiple linear regression analysis was used to explore the relationship between lymph node counts and patient- and surgery-related factors. For survival analysis, a multivariable Cox regression method was used.

Results

A total of 317 patients (160 females) were included. Median (range) age was 74 (30–95) years. Median number of lymph node retrieval was 32 (8–198) and was associated with increased specimen length but not to arterial vessel length. One hundred and thirty-three (42%) patients had lymph node metastases. All patients had these located < 5 cm from the tumour. Ten, two, and three specimens had lymph node metastases around the central and peripheral ligation of the ileocolic artery and at the central ligation of the inferior mesenteric artery, respectively. The tumour stages in these specimens were T3-4N2M0-1. No statistically significant survival benefit was associated with longer arterial vessel length (p = 0.429).

Conclusions

Neither retrieval of lymph nodes nor statistically significant survival was affected by vessel length in standardized left- and right-sided colon cancer surgery.
The Good and the Bad: Do Immigrants’ Positive and Negative Evaluations of Life After Migration Go Hand in Hand?
Authors: Geurts Nella , Lubbers Marcel
Published: October 2022

Research on migration and integration has informed us about the systemic inequalities and disadvantages that migrants face in the residence country. Less is known about migrants’ positive experiences, and whether these co-exist with negative experiences. This study’s contribution lies in exploring to what extent positive and negative evaluations go hand in hand and among whom in what way. By coding and analysing open-ended questions of the New Immigrants Survey, we explore this among 955 immigrants from Bulgaria, Poland, Spain and Turkey who have been in the Netherlands for around 5 years. Results illustrate that these migrants most often positively evaluate matters in the economic domain, whereas the domain that is most often negatively evaluated concerns (being apart from) family. Which positive and negative evaluations are mentioned simultaneously differs among migrants, where migrants from Spain more often combine a negative evaluation of the Dutch whether with a positive evaluation of the Dutch being friendly. Migrants with a temporary intention to stay are more likely to combine a positive evaluation of the economic domain with negative experiences in the integration domain. This study hereby illustrates that the current emphasis in migration research on “the bad” overlooks positive matters that migrants experience simultaneously.
A wise person plants a tree a day before the end of the world: coping with the emotional experience of climate change in Poland
Authors: Zaremba D. , Kulesza M. , Herman A. M. , Marczak M. , Kossowski B. , Budziszewska M. , Michałowski J. M. , Klöckner C. A. , Marchewka A. , Wierzba M.
Published: October 2022

It is now widely accepted that we are in a climate emergency, and the number of people who are concerned about this problem is growing. Yet, qualitative, in-depth studies to investigate the emotional response to climate change were conducted either in high-income, western countries, or in low-income countries particularly vulnerable to climate change. To our knowledge, there are no qualitative studies conducted in countries that share great barriers to decarbonization while being significant contributors to carbon emissions. Since climate change affects people globally, it is crucial to study this topic in a variety of socio-political contexts. In this work, we discuss views and reflections voiced by highly concerned residents of Poland, a Central European country that is a major contributor to Europe's carbon emissions. We conducted 40 semi-structured interviews with Polish residents, who self-identified as concerned about climate change. A variety of emotions related to climate change were identified and placed in the context of four major themes: dangers posed by climate change, the inevitability of its consequences, attributions of responsibility, and commonality of concern. Our findings highlight a variety of often ambivalent and conflicting emotions that change along with the participant’s thoughts, experiences and behaviours. Furthermore, we describe a wide repertoire of coping strategies, which promoted well-being and sustained long-term engagement in climate action. As such, our work contributes to research on a broad array of climate-related emotions.
Metabolic tumor volume predicts long-term survival after transplantation for unresectable colorectal liver metastases: 15 years of experience from the SECA study
Authors: Grut Harald , Line Pål-Dag , Syversveen Trygve , Dueland Svein
Published: October 2022

Objective

To report 15 years of experience with metabolic tumor volume (MTV) of liver metastases from the preoperative 18F-FDG PET/CT to predict long-term survival after liver transplantation (LT) for unresectable colorectal liver metastases (CRLM).

Methods

The preoperative 18F-FDG PET/CT from all SECA 1 and 2 patients was evaluated. MTV was obtained from all liver metastases. The patients were divided into one group with low MTV (< 70 cm3) and one group with high MTV (> 70 cm3) based on a receiver operating characteristic analysis. Overall survival (OS), disease-free survival (DFS) and post recurrence survival (PRS) for patients with low versus high MTV were compared using the Kaplan–Meier method and log rank test. Clinopathological features between the two groups were compared by a nonparametric Mann–Whitney U test for continuous and Fishers exact test for categorical data.

Results

At total of 40 patients were included. Patients with low MTV had significantly longer OS (p < 0.001), DFS (p < 0.001) and PRS (p = 0.006) compared to patients with high values. The patients with high MTV had higher CEA levels, number of liver metastases, size of the largest liver metastasis, N-stage, number of chemotherapy lines and more frequently progression of disease at LT compared to the patients with low MTV.

Conclusion

MTV of liver metastases is highly predictive of long-term OS, DFS and PRS after LT for unresectable CRLM and should be implemented in risk stratification prior to LT.
Diploid Potatoes as a Catalyst for Change in the Potato Industry
Authors: Bethke Paul C. , Halterman Dennis A. , Francis David M. , Jiang Jiming , Douches David S. , Charkowski Amy O. , Parsons Joshua
Published: October 2022

In response to increasing interest in diploid potato (Solanum tuberosum) breeding and the production of diploid inbred hybrid potato varieties, the Breeding and Genetics section of the Potato Association of America (PAA) organized a symposium on diploid breeding that took place during the 2021 PAA annual meeting. Proceedings from that symposium are documented in this manuscript. Speakers from academia, government and industry presented their unique perspectives. Presentations covered a wide range of topics. Potential advantages of diploid breeding were introduced, and reasons to be skeptical about diploid breeding were highlighted. The impact that diploid breeding might have on the potato seed industry was discussed. Advantages for genetics research were emphasized. Aspects of tomato breeding and production were reviewed and considered as potential models for diploid potato breeding and production activities. Lastly, an industry-centered view of diploid potato breeding was provided. Taken together, these presentations are a snapshot of how diploid potato breeding was viewed in the moment, a vision for how diploid breeding might be implemented, and a thoughtful reflection on how diploid breeding and inbred hybrid varieties might change the potato variety development process and impact the potato industry.
Vegetation dynamics in a disturbed lacustrine record: The Eocene maar lake of Groß-Zimmern (Hesse, SW Germany)
Authors: Mutzl Jürgen , Lenz Olaf K. , Wilde Volker , Krahn Kim J. , Moshayedi Maryam , Hinderer Matthias
Published: October 2022

Palynological studies of lacustrine sediments in Eocene maar craters on the Sprendlinger Horst (Hesse, SW Germany) are complemented by 26 core samples from Groß-Zimmern. In addition, diatoms have been studied to assess palaeolimnological conditions. The palynomorph assemblage proves a middle Eocene age more or less coeval to the upper part of the nearby lacustrine succession at Messel. The core includes 33 m of massive to finely laminated bituminous shale abruptly following the underlying breccia of the diatreme filling. The lacustrine deposits are characterised by frequent mass movements and redeposition probably due to tectonic activity in combination with syn- and postsedimentary subsidence in the lake basin. Together with a diatom assemblage characteristic for shallow to moderately deep water, this indicates that the core was drilled in the area of a marginal syncline rather than in the centre of the basin. Freshwater conditions with low nutrient levels were inferred for Lake Groß-Zimmern from diatoms and coccal green algae. Despite the strong disturbance of the sedimentary record, results of cluster analysis and non-metric multidimensional scaling (NMDS) of the palynomorph assemblages can be compared to the undisturbed succession from Messel. This includes successional stages of the azonal vegetation in the crater area during an initial and early recolonisation phase as well as in the zonal vegetation, which are related to the reoccupation of the crater area by a thermophilic forest. Furthermore, slight changes of the climate can be inferred.
Exploring the dynamics of graph algorithms
Authors: Burch Michael , van de Wetering Huub , Wallner Günter , Rooks Freek , Morra Olof
Published: October 2022

In this paper, we describe an interactive visualization tool for representing the dynamics of graph algorithms. To reach this goal, we designed a web-based framework which illustrates the dynamics as time-to-space mappings of dynamic graphs. Such static diagrams of dynamic data have the benefit of being able to display longer time spans in one view, hence supporting the observer with comparison tasks which is challenging or even impossible for graph algorithm animations. Our tool can show details about how an algorithm traverses a graph step-by-step in a static and animated fashion, for graph algorithm exploration as well as educational purposes. The animation together with the time-to-space mapping hence forms an overview-and-detail approach. We also allow changing of speed, replaying, stopping, storing intermediate stages with parameter configurations, as well as measuring and monitoring performance and memory consumption to eventually identify bottlenecks in a graph algorithm. By using flight carrier data from the United States Department of Transportation and a network of autonomous systems we demonstrate how we used the tool to explore two standard graph-theoretic algorithms. Finally, we discuss scalability issues and limitations.

Graphical abstract
Selection of Relevant Bacterial Strains for Novel Therapeutic Testing: a Guidance Document for Priority Cystic Fibrosis Lung Pathogens
Authors: Mahenthiralingam Eshwar , Weiser Rebecca , Floto R. Andres , Davies Jane C. , Fothergill Joanne L.
Published: October 2022

Purpose of Review

People with cystic fibrosis (CF) suffer chronic lung infections with a range of antimicrobial-resistant bacterial pathogens. There is an urgent need for researchers to develop novel anti-infectives to treat these problematic infections, but how can we select bacterial strains which are relevant for robust testing and comparative research?

Recent Findings

Pseudomonas aeruginosa,Burkholderia cepaciacomplex andBurkholderia gladioli,Mycobacterium abscessuscomplex,Staphylococcus aureus, Haemophilus influenza,and several multidrug-resistant Gram-negative species were selected as key CF infections that urgently require new therapeutics. Reference isolates and strain panels were identified, and a summary of the known genotypic diversity of each pathogen was provided.

Here, we summarise the current strain resources available for priority CF bacterial pathogens and highlight systematic selection criteria that researchers can use to select strains for use in therapeutic testing.
T-spherical uncertain linguistic MARCOS method based on generalized distance and Heronian mean for multi-attribute group decision-making with unknown weight information
Authors: Wang Haolun , Ullah Kifayat
Published: October 2022

The T-spherical uncertain linguistic (TSUL) sets (TSULSs) integrated by T-spherical fuzzy sets and uncertain linguistic variables are introduced in this article. This new concept is not only a generalized form but also can integrate decision-makers’ quantitative evaluation ideas and qualitative evaluation information. The TSULSs serve as a reliable and comprehensive tool for describing complex and uncertain decision information. This paper focuses on an extended MARCOS (Measurement of Alternatives and Ranking according to the Compromise Solution) method to handle the TSUL multi-attribute group decision-making problems where the weight information is completely unknown. First, we define, respectively, the operation rules and generalized distance measure of T-spherical uncertain linguistic numbers (TSULNs). Then, we develop two kinds of aggregation operators of TSULNs, one kind of operator with independent attributes is T-spherical uncertain linguistic weighted averaging and geometric (TSULWA and TSULWG) operators, and the other is T-spherical uncertain linguistic Heronian mean aggregation operators (TSULHM and TSULWHM) considering attributes interrelationship. Their related properties are discussed and a series of reduced forms are presented. Subsequently, a new TSUL-MARCOS-based multi-attribute group decision-making model combining the proposed aggregation operators and generalized distance is constructed. Finally, a real case of investment decision for a community group-buying platform is presented for illustration. We further test the rationality and superiorities of the proposed method through sensitivity analysis and comparative study.
Analysis of factors that influence adoption of agroecological practices in viticulture
Authors: Ghali Mohamed , Ben Jaballah Maha , Ben Arfa Nejla , Sigwalt Annie
Published: October 2022

Public policy reforms and consumer requirements for the environment have raised awareness among winegrowers of the need to review their farming practices. This renewal of production aims for high economic, environmental, and social performance, as well as product quality. Therefore, it often assumes changes in farming practices due to adoption of agroecological practices (AEP). However, adopting these changes depends not only on demonstrating positive economic and environmental impacts of AEP but also positive social impacts. This study investigated winegrowers’ perceptions of AEP and analyzed the most important drivers of adoption of AEP. It was based on quantitative economic and sociological data from a survey of winegrowers in the Loire Valley (France). An original scoring method was used to identify adopters and non-adopters of AEP. Then, a logit econometric model was used to explore statistically significant relations between the adoption of AEP and internal and external farm variables. Results confirmed that winegrowers’ perceptions converged with the results of the econometric analysis. AEP were adopted mainly by winegrowers sensitive to human health. Adoption also depended on the context and type of AEP: wine tourism activities on the farm, environmental training, and sales revenue were positively correlated with the adoption of AEP. However, the absence of partners, vineyard area and winemaking on the farm were negatively correlated with adoption. Thus, public and private agricultural actors should consider these influential factors to increase adoption of AEP by farmers.
Design of 3-D trajectory sequences for multiple asteroid flyby missions
Authors: Cataldi Giuseppe , Marcuccio Salvo
Published: October 2022

Prospecting is a necessary pre-requisite of future asteroid mining ventures. It is generally assumed that inspection for the purpose of identifying the asteroid composition can be effectively accomplished from a distance through remote sensing. To be carried out in a timely and economically viable way, prospecting is best performed by devising trajectories such that a single spacecraft manages to fly by as many asteroid as possible, yet seeking to minimize a cost function that we assume to be coincident with propellant consumption. In this paper, we present a method to identify trajectory sequences to multiple asteroids. We restrict our analysis to Near-Earth Asteroids (NEAs), i.e.,, those with perihelion at less than 1.3 AU from the Sun, focusing on Apollo class NEAs only. The volume of space where encounter seeking takes place is a torus-shaped 3-D region in the proximity of the ecliptic. Under the assumption of using impulsive maneuvers to connect ballistic coast arcs, we show that a deterministic building blocks approach is successful in finding a significant number of multi-flyby mission profiles with the desired characteristics. Using this scheme, it is possible to envisage realistic asteroid prospecting missions using a single launch to deploy a number of small spacecraft, with tens—or possibly hundreds—of asteroids visited in a few years.
Considerations for Embedding Inclusive Research Principles in the Design and Execution of Clinical Trials
Authors: Peters Ubong , Turner Brenna , Alvarez Daniel , Murray Makaelah , Sharma Aruna , Mohan Shalini , Patel Shilpen
Published: October 2022

There is a growing recognition that the clinical research enterprise has a diversity problem, given that many clinical trials recruit historically marginalized individuals or patients reflective of real-world data at a rate that is far below the incidence and prevalence of the disease for which the investigational therapy or device is targeting. This lack of diversity in clinical research participation can obscure the safety and efficacy of drug therapies and limits our collective ability to develop effective treatments for all patients, leading to even wider health disparities. This review article provides an in-depth analysis of the impact of this bias on public health, along with a description of some of the barriers that prevent historically marginalized populations from participating in clinical research. Some practical solutions that can be employed to increase diversity in clinical trial participation are also discussed, including the crucial role clinical trial sponsors, research organizations, patients, and caregivers need to play in supporting the industry to achieve this ambitious but necessary goal.
Perceptions Among Backcountry Skiers During the COVID-19 Pandemic: Avalanche Safety and Backcountry Habits of New and Established Skiers
Authors: Valle Esteban A. , Cobourn Andrew P. , Trivitt Spencer JH. , Hendrikx Jordy , Johnson Jerry D. , Fiore David C.
Published: October 2022

Introduction

The coronavirus disease 2019 (COVID-19) pandemic impacted the ski industry worldwide by closing or limiting access to ski resorts. Subsequently, anecdotal reports of increased backcountry use emerged in the press, with concerns of inexperienced skiers causing or having problems in the backcountry. This study attempted to quantify this and identify motivations for new backcountry skiers.

Methods

Self-identified backcountry skiers and snowboarders (aged ≥18 y) in the United States and Canada completed an anonymous 29-question online survey distributed by regional avalanche centers, education providers, and skiing organizations (n =4792). Respondents were stratified by backcountry experience, defining “newcomers” who began backcountry skiing from 2019 to 2021, coincident with the COVID-19 pandemic. Percentages of ski days spent in the backcountry were compared before and during the COVID-19 pandemic using paired t-tests and across cohorts using repeated-measures analysis of variance. Avalanche education was compared using unpaired χ2 tests.

Results

Of established skiers, 81% noticed more people in the backcountry and 27% reported increasing their own use. Participants reported spending 17% (95% CI, 15.8–17.9) more of their days in the backcountry during the COVID-19 pandemic, with newcomers increasing their time spent by 36% and established skiers increasing their time spent by 13% ( P<0.0001). Of newcomers, 27% cited the COVID-19 pandemic as motivation to enter the backcountry and 24% lacked formal avalanche education, which is significantly higher than the 14% of established skiers ( P<0.0001).

Conclusions

Influenced by factors related to COVID-19, reported backcountry use increased during the pandemic. Newcomers had a lower level of avalanche education and less confidence in evaluating terrain. Because 80% of participants were recruited from avalanche safety or education websites, this likely underestimates skiers lacking avalanche awareness or education and is further limited by the nature of online surveys.
Misanthropology: the makers of Siliva the Zulu
Authors: Davis Peter
Published: October 2022

This lecture of 2006, never previously published, describes the making of the film Siliva the Zulu, the first fiction film made in sub-Saharan Africa with an all-black cast. It assesses its value as a rare documentary record of rural Zulu life in the 1920s and the subsequent careers of the film maker Attilio Gatti and anthropologist Lidio Cipriani. The latter’s reputation was tarnished by his support for Mussolini, racism, anti-Semitism and fascism.
Learning From Simulating Mass Casualty Events: A Systematic Search and a Comprehensive Qualitative Review
Authors: Ledbury Kathryne , Glasgow Simon , Tallach Rosel
Published: October 2022

Mass casualty events (MCE) strain available health-care resources requiring extraordinary measures. Simulated exercises are used to improve preparedness. We sought to identify learning points and common themes arising from such exercises in literature. Reporting of action points to improve response plans were investigated. Type of exercises, environments, and departments were also explored. We systematically searched 3 databases and applied our eligibility criteria. Inclusion criteria were in-situ MCE simulations of clinical response to traumatic MCEs, including scene management, prehospital care, and in hospital care. Exclusion criteria were nonmedical response, infectious outbreaks, training courses with self-selecting participants, simulations assessing mechanical tools, and mathematical modeling. A total of 6883 titles were identified and screened. Eighty-three studies were read in full. Twenty-two articles were included. We identified numerous learning points, which were collated and categorized into 11 themes. Fifty-nine percent of the papers reported actions that would be or had been implemented. MCE simulation exercises have been found to improve familiarity and confidence among participants. The 11 themes identified from published exercises overlap with areas of improvement from real events. MCE simulations in the literature appear to focus on carrying out the exercise itself rather than learning points possibly missing opportunities to improve response plans.
“Constrained Medical Oxygen Supply Chain in India During COVID-19: Red-tapism, the Elephant in the Room?”
Authors: Gowda Naveen R. , Siddharth Vijaydeep , Kumar Parmeshwar , Vikas H. , Swaminathan Prakash , Kumar Atul
Published: October 2022

Background:

Recent disruption of medical oxygen during the second wave of coronavirus disease 2019 (COVID-19) has caused nationwide panic. This study attempts to objectively analyze the medical oxygen supply chain in India along the principles of value stream mapping (VSM), identify bottlenecks, and recommend systemic improvements.

Methods:

Process mapping of the medical oxygen supply chain in India was done. Different licenses and approvals, their conditions, compliances, renewals, among others were factored in. All relevant circulars (Government Notices), official orders, amendments, and gazette notifications pertaining to medical oxygen from April 2020 to April 2021 were studied and corroborated with information from Petroleum and Explosives Safety Organization (PESO) official website.

Results:

Steps of medical oxygen supply chain right from oxygen manufacture to filling, storage, and transport up to the end users; have regulatory bottlenecks. Consequently, flow of materials is sluggish and very poor information flow has aggravated the inherent inefficiencies of the system. Government of India has been loosening regulatory norms at every stage to alleviate the crisis.

Conclusions:

Regulatory bottlenecks have indirectly fueled the informal sector over the years, which is not under Government’s control with difficulty in controlling black-marketing and hoarding. Technology enabled, data-driven regulatory processes with minimum discretionary human interface can make the system more resilient.
Czecho(slovak) Sinology
Authors: Lomová Olga
Published: October 2022

In the second half of the twentieth century, Czechoslovak Sinology gained international recognition and, beginning in the late 1970s, has sometimes been referred to as the “Prague School of Sinology.” This paper will contextualize the achievements of Czechoslovak Sinologists in the broader historical context of the study of China, in the end summarizing the present situation in the Czech Republic. It discusses both Czechoslovak and Czech Sinology as the product of a specific intellectual environment that has nourished academic interest in China and shaped a specific understanding of what “Sinology” (side by side with other “Oriental studies”) means, including its situatedness in specific moments of history.
Optimising MWA EoR data processing for improved 21-cm power spectrum measurements—fine-tuning ionospheric corrections
Authors: Chege J. Kariuki , Jordan C. H. , Lynch C. , Trott C. M. , Line J. L. B. , Pindor B. , Yoshiura S.
Published: October 2022

The redshifted cosmological 21-cm signal emitted by neutral hydrogen during the first billion years of the universe is much fainter relative to other galactic and extragalactic radio emissions, posing a great challenge towards detection of the signal. Therefore, precise instrumental calibration is a vital prerequisite for the success of radio interferometers such as the Murchison Widefield Array (MWA), which aim for a 21-cm detection. Over the previous years, novel calibration techniques targeting the power spectrum paradigm of EoR science have been actively researched and where possible implemented. Some of these improvements, for the MWA, include the accuracy of sky models used in calibration and the treatment of ionospheric effects, both of which introduce unwanted contamination to the EoR window. Despite sophisticated non-traditional calibration algorithms being continuously developed over the years to incorporate these methods, the large datasets needed for EoR measurements require high computational costs, leading to trade-offs that impede making use of these new tools to maximum benefit. Using recently acquired computation resources for the MWA, we test the full capabilities of the state-of-the-art calibration techniques available for the MWA EoR project, with a focus on both direction-dependent and direction-independent calibration. Specifically, we investigate improvements that can be made in the vital calibration stages of sky modelling, ionospheric correction, and compact source foreground subtraction as applied in the hybrid foreground mitigation approach (one that combines both foreground subtraction and avoidance). Additionally, we investigate a method of ionospheric correction using interpolated ionospheric phase screens and assess its performance in the power spectrum space. Overall, we identify a refined RTS calibration configuration that leads to an at least 2 factor reduction of the EoR window power contamination at the$0.1 \; \textrm{hMpc}^{-1}$scale. The improvement marks a step further towards detecting the 21-cm signal using the MWA and the forthcoming SKA low telescope.
Far-field brittle deformation record in the eastern Paris Basin (France)
Authors: Blaise Thomas , Ali Khoudja Sid Ahmed , Carpentier Cédric , Brigaud Benjamin , Missenard Yves , Mangenot Xavier , Boulvais Philippe , Landrein Philippe , Cochard Jean
Published: October 2022

Jurassic carbonate strata in the eastern Paris Basin exhibit several generations of faults, tension gashes and stylolites. Although their relative chronology can sometimes be determined according to cross-cutting relationships, the duration of major deformation phases and their influence on fluid flow and carbonate cementation are still uncertain. This contribution aims to clarify the timing of brittle deformation and associated calcite cementation. Tension gashes filled by calcite in Jurassic carbonates were sampled in outcrops and boreholes and dated through U–Pb geochronology. Almost all the sampled fractures were cemented during the Cenozoic period. Continuous deformation spread from c. 50 to 30 Ma. Tension gashes oriented N10° to N20° dated at 48–43 Ma show the main Pyrenean contractional stage. A second set of calcites were dated at c. 35–33 Ma and document a Late Eocene – Oligocene extension. A transition from the compressional to the extensional regime is expressed by tension gashes dated between 43 and 35 Ma. Finally, tension gashes oriented N150° to N175°, dated between 32 and 18 Ma, may result from the propagation of the horizontal stress generated by the Alpine orogen or by late Pyrenean deformation. Clumped isotope thermometry on five samples revealed both low crystallization temperatures (from 27 to 53 °C) and the meteoric origin of calcite-precipitating fluids. Our research therefore documents a continuous fracturing from Ypresian to Rupelian times, and less expressed brittle deformation during the Miocene period.
Infant baptism and the disposition to saving faith
Authors: Crisp Oliver D.
Published: October 2022

Reformed accounts of infant baptism are usually covenantal and promissory in nature. They are about bringing the child into the ambit of the visible church in the hope the infant will own the faith upon reaching the age of reason. This paper sets out an alternative Reformed account of baptism, drawing on the Scottish confessional tradition. On this account, infants have a disposition to faith conveyed to them in baptism that will in due course become dispositional faith exercised in saving faith. Thus, baptism involves regeneration – or something close to it.
Network analysis for modeling complex systems in SLA research
Authors: Freeborn Lani , Andringa Sible , Lunansky Gabriela , Rispens Judith
Published: October 2022

Network analysis is a method used to explore the structural relationships between people or organizations, and more recently between psychological constructs. Network analysis is a novel technique that can be used to model psychological constructs that influence language learning as complex systems, with longitudinal data, or cross-sectional data. The majority of complex dynamic systems theory (CDST) research in the field of second language acquisition (SLA) to date has been time-intensive, with a focus on analyzing intraindividual variation with dense longitudinal data collection. The question of how to model systems from a structural perspective using relation-intensive methods is an underexplored dimension of CDST research in applied linguistics. To expand our research agenda, we highlight the potential that psychological networks have for studying individual differences in language learning. We provide two empirical examples of network models using cross-sectional datasets that are publicly available online. We believe that this methodology can complement time-intensive approaches and that it has the potential to contribute to the development of new dimensions of CDST research in applied linguistics.
Predicting suitable habitat for the endangered plant Cephalotaxus oliveri Mast. in China
Authors: Xie Chunping , Huang Boyang , Jim CY , Liu Dawei , Liu Chang , Zhu Zhenxiang
Published: October 2022

The coniferous shrub Oliver’s plum yew (Cephalotaxus oliveri) is endemic to southern China with potential medicinal use for cancer treatment and ecological value in sustaining China’s threatened subtropical forest ecosystems. Comprehensive understanding of the current spatial patterns of this vulnerable species vis-à-vis climatic conditions is crucial for its sustained economic use and conservation. Based on 100 reliable occurrence records and nine environmental variables, MaxEnt and QGIS programs were used to predict the potential geographical distribution of C. oliveri in China. Combined with percentage contribution and permutation importance, the jackknife statistical method was used to test and evaluate pertinent factors restricting the potential distribution of C. oliveri. The response curves of critical bioclimatic factors were employed to determine the potential species range. The current core potential distribution areas were concentrated in China’s central and south-west regions. Temperature was identified as the crucial determinant of species distribution patterns, particularly the mean temperature of the coldest quarter. Precipitation was a necessary but not critical secondary factor. These findings should inform the ex situ conservation and cultivation of C. oliveri in China and its introduction to other parts of the world for similar purposes.
Effectiveness of caregiver-mediated intervention: a pilot study for children with neurodevelopmental disorders
Authors: Ge Dongmei , Wei Hua , Wang Yue , Li Yan , Luo Jinmei , Liu Xiao , Hu Yan , Chen Li , Cheng Qian , Li Tingyu , Dai Ying
Published: October 2022

Objectives:

Caregiver-mediated intervention (CMI), based on parent skills training, is a family-mediated intervention model for children with neurodevelopmental disorders, in particular autism spectrum disorder. This study aimed to evaluate the effectiveness of CMI.

Methods:

Thirty-three children (aged 22–69 months from our department) and their caregivers participated in a two-week training course of ten 90-minute lessons. Caregivers were encouraged to try their best to apply intervention skills in both home routines and play routines to encourage the development of cognition, motion, social adaptability, and behavior of children. Demographic information, video-recorded data, and diagnostic scales were collected at two key time points: baseline and post-training (PT – within six months).

Results:

Three aspects were assessed – primary variables, secondary variables, and correlation analyses. Results showed an improvement in PT in (1) Adult/Child Interaction Fidelity Rating (P < 0.01) and (2) adaptability of Gesell Developmental Scale and stereotyped behaviors and limited interests of Autism Diagnostic Observation Schedule (P < 0.05, P < 0.01). Moreover, a negative correlation occurred between caregiver skill improvement and parent education (P < 0.05), but without correlations with other demographics.

Conclusions:

As an efficacious family intervention for both children and their caregivers, CMI is worth being generalized widely.