bluuebunny/crossref_metadata_2025 huggingface dataset:
The efficacy of larotrectinib (LOXO-101), a selective tropomyosin receptor kinase (TRK) inhibitor, in adult and pediatric TRK fusion cancers.
Authors: Hyman David Michael , Laetsch Theodore Willis , Kummar Shivaani , DuBois Steven G. , Farago Anna F. , Pappo Alberto S. , Demetri George D. , El-Deiry Wafik S. , Lassen Ulrik Niels , Dowlati Afshin , Brose Marcia S. , Boni Valentina , Turpin Brian , Nagasubramanian Ramamoorthy , Cruickshank Scott , Cox Michael Craig , Ku Nora C. , Hawkins Douglas S. , Hong David S. , Drilon Alexander E.
Published: June 2017

LBA2501

Background: Larotrectinib is the first selective small-molecule pan-TRK inhibitor. TRK fusions appear oncogenic independent of tumor lineage, are widely distributed across cancers, and affect all ages. We present an integrated dataset from 3 studies intended to support regulatory approval. Methods: All NTRK fusion pts with RECIST measurable disease enrolled to the adult (NCT02122913, n=8) and pediatric (NCT02637687, n=12) phase I trials and adult/adolescent phase 2 trial (NCT02576431, n=35) were analyzed. TRK fusion status was determined by local testing prior to enrollment. Pts were dosed predominantly at 100mg BID on a continuous 28-day schedule. Primary objective was investigator-assessed overall response rate (ORR) per RECIST v1.1. Secondary endpoints included duration of response (DOR) and safety. Data were cut on 31-JAN-2017. Results: 55 TRK fusion pts (12 peds, 43 adult, range: 4 mo.-76 yrs) were enrolled (median priors=2). Fusions involved NTRK1 (n=25), NTRK2 (n=1), and NTRK3 (n=29), and 14 unique partners. 13 discrete tumor types were treated: salivary (12), sarcoma (10), infantile fibrosarcoma (7), lung (5), thyroid (5), colon (4), melanoma (4), cholangio (2), GIST (2), and other (4). For the 46 pts evaluated to date, the ORR was 78% (95% CI: 64%–89%) with responses in 12 unique tumor types. Responses are ongoing in 29/33 (88%) pts, excluding 3 peds pts whose DOR was censored at attempted curative resection. A median DOR has not been reached as the majority of responders remain on treatment without progression. The longest responder remains on treatment at 23 mos., 8 pts remain in response at >12 mos., and 16 pts at >6 mos. NTRK solvent front mutations were detected in all 4 pts to develop acquired resistance. The most common TEAEs were fatigue (30%), dizziness (28%), and nausea (28%). 5 (11%) pts required dose reductions. Conclusions: Larotrectinib has demonstrated consistent and durable antitumor activity in TRK fusion cancers, across a wide range of ages and tumor types, and was well-tolerated. Larotrectinib could be the first targeted therapy developed in a tissue type-agnostic manner, and the first developed simultaneously in adults and pediatrics. Clinical trial information: NCT02576431, NCT02122913, NCT02637687.
APHINITY trial (BIG 4-11): A randomized comparison of chemotherapy (C) plus trastuzumab (T) plus placebo (Pla) versus chemotherapy plus trastuzumab (T) plus pertuzumab (P) as adjuvant therapy in patients (pts) with HER2-positive early breast cancer (EBC).
Authors: Von Minckwitz Gunter , Procter Marion Jennifer , De Azambuja Evandro , Zardavas Dimitrios , Knott Adam , Viale Giuseppe , Suter Thomas M. , Arahmani Amal , Rouchet Nathalie , Clark Emma , Benyunes Mark , Lang Istvan , Levy Christelle , Yardley Denise A. , Bines Jose , Gelber Richard D. , Piccart-Gebhart Martine J. , Baselga Jose
Published: June 2017

LBA500

Background: In previous trials P significantly prolonged progression free and overall survival and increased pCR rates when added to T+C in pts with HER2-positive breast cancer (BC). The APHINITY trial was designed to test whether the addition of P to adjuvant T+C improves pt outcomes. Methods: Pts with adequately excised HER2-positive, pT1-3 EBC were randomly assigned to receive standard adjuvant C plus one year of either T + P or T + Pla. Eligible pts had either node-positive disease, or node-negative disease (pN0) and a tumor size of > 1.0 cm. Pts with pN0, T1b tumors with high risk features were initially eligible. The primary efficacy endpoint was invasive disease-free survival (IDFS); we assumed a 3-year IDFS of 91.8% with P and 89,.2% with Pla. Results: 4805 pts were randomized to C and T plus either P (n = 2400) or Pla (n = 2405). Baseline demographics and tumor characteristics between the arms were well balanced, with 63% and 36% of pts having node-positive and hormone receptor negative EBC respectively. P and Pla treatments were completed in 84.5% and 87.4% of patients, respectively. IDFS events occurred in 171 (7.1%) P pts and 210 (8.7%) Pla pts (hazard ratio (HR) 0.81 (95% CI 0.68-1.00), P = 0.045). Estimates of IDFS at 3 years were 94.1% and 93.2% in the P and Pla arms, respectively. The node-positive cohort had a 3-year IDFS rate of 92.0% for P compared with 90.2% for Pla (HR 0.77 (95% CI 0.62-0.96), P = 0.019). The pN0 cohort had a 3-year IDFS rate of 97.5% for P and 98.4% for Pla; HR = 1.13 (95% CI 0.68-1.86). The safety profile of P was consistent with previous trials. For the primary cardiac endpoint (heart failure or cardiac death) and secondary cardiac endpoint (asymptomatic or mildly symptomatic LVEF decline) rates were low, 0.7% vs 0.3% and 2.7% vs 2.8%, in the P and Pla arms, respectively. Diarrhea grade ≥3 was more frequent with P (9.9% vs 3.7%). Conclusions: The APHINITY trial met its primary endpoint: P significantly improved IDFS in patients with HER2-positive EBC when added to T+C. No new safety signals were identified. Clinical trial information: NCT01358877.
Adding abiraterone for men with high-risk prostate cancer (PCa) starting long-term androgen deprivation therapy (ADT): Survival results from STAMPEDE (NCT00268476).
Authors: James Nicholas D. , De Bono Johann S. , Spears Melissa Ruth , Clarke Noel , Mason Malcolm David , Dearnaley David P. , Ritchie Alastair W S , Russell J. Martin , Gilson Clare , Jones Robert J. , Gillessen Silke , Matheson David , Aung San , Birtle Alison J. , Chowdhury Simon , Gale Joanna , Malik Zafar , O'Sullivan Joe M. , Parmar Mahesh K B , Sydes Matthew Robert
Published: June 2017

LBA5003

Background: Abiraterone showed a survival advantage in men with castration-refractory prostate cancer. We assessed whether abiraterone would work earlier in the disease. STAMPEDE is a randomized controlled trial using a multi-arm multi-stage platform design. It recruits patients (pts) with high-risk locally advanced or metastatic PCa starting long-term ADT. We report the first comparative survival data. Methods: The standard-of-care (SOC) was ADT for 2+yrs; radiotherapy (RT) was mandated for men with N0M0 disease & encouraged for N+M0. Stratified randomization allocated pts 1:1 to SOC or SOC+abiraterone 1000mg + prednisolone 5mg daily. Treatment duration depended on stage & intent to give radical RT: pts not having RT or M1 disease, treatment continued until PSA, radiological & clinical progression; otherwise treatment continued until the earlier of 2 years or all types of progression. The primary outcome measure was death from any cause. Comparison to control for survival had 90% power at 2.5% 1-sided alpha for hazard ratio (HR) of 0.75, requiring ~267 control arm deaths, accounting for 3 intermediate lack-of-benefit analyses on failure-free survival (FFS). Analyses used Cox proportional hazards & flexible parametric models, adjusted for stratification factors. Results: 1,917 pts were contemporaneously randomized to these arms (Nov 2011- Jan 2014). Groups were balanced: median age 67yrs; 52% metastatic, 20% N+/X M0, 28% N0M0; 95% newly-diagnosed; median PSA 53ng/ml. Median follow-up was 40m. There were 262 control arm deaths (82% PCa). The adjusted HR = 0.63 (95% CI 0.52-0.76; p=0.115x10-7; 184 deaths) for SOC+Abi vs SOC, with 3yr OS improved from 76% to 83%. There were 535 control arm FFS events; the adjusted HR = 0.29 (95% CI 0.25-0.34; p = 0.377x10-63, 248 FFS events) for SOC+Abi vs SOC. Grade 3 & 4 adverse events were seen in 29% & 3% SOC, 41% & 5% SOC+Abi; Grade 5: 3 & 9 (1 & 2 related). Conclusions: The results show a clinically & statistically significant effect on overall survival & failure-free survival from adding abiraterone at start of ADT with a manageable increase in toxicity. ADT (+/- RT) + abiraterone is a new standard of care for this group. Clinical trial information: NCT00268476.
Melatonin attenuates phenotypic flexibility of energy metabolism in a photoresponsive mammal, the Siberian hamster
Authors: Boratyński Jan S. , Jefimow Małgorzata , Wojciechowski Michał S.
Published: June 2017

The duration of melatonin (MEL) secretion conveys information about day length and initiates a cascade of seasonal phenotypic adjustments in photoresponsive mammals. With shortening days they cease reproduction, minimize energy expenditure, enhance thermoregulatory capacity and adjust functioning of the hypothalamic-pituitary-adrenal (HPA) axis to match the winter increase in energy demands. Within each season stress plays an important role in the flexible adjustments of a phenotype to environmental perturbations. Recent studies showed that thermal reaction norms of energy metabolism were narrower in winter-acclimated Siberian hamsters, Phodopus sungorus. We tested the hypothesis that physiological changes occurring in response to prolonged MEL signal, including changes in secretion of stress hormones, are responsible for the seasonal decrease in phenotypic flexibility of energy metabolism in photoresponsive mammals. To quantify reaction norms for basal metabolic rate (BMR) and cortisol (CORT) secretion, male Siberian hamsters maintained at long (16L:8D) photoperiod were acclimated repeatedly for 12 days to 10 and 28°C. As predicted, the phenotypic flexibility of BMR decreased when animals were supplemented with MEL. However, at the same time mean CORT concentration, and the reaction norm for its secretion in response to changes in acclimation temperature increased. These results suggest that decreased sensitivity of HPA axis to CORT signal, rather than changes in CORT level itself, is responsible for the decreased phenotypic flexibility in photoresponsive species. Our results suggest that decreased phenotypic flexibility in winter, together with increased stress hormone secretion make photosensitive species more vulnerable to climate changes.
Recent advances in the understanding of renal inflammation and fibrosis in lupus nephritis
Authors: Yung Susan , Yap Desmond YH , Chan Tak Mao
Published: June 2017

Lupus nephritis is a potentially reversible cause of severe acute kidney injury and is an important cause of end-stage renal failure in Asians and patients of African or Hispanic descent. It is characterized by aberrant exaggerated innate and adaptive immune responses, autoantibody production and their deposition in the kidney parenchyma, triggering complement activation, activation and proliferation of resident renal cells, and expression of pro-inflammatory and chemotactic molecules leading to the influx of inflammatory cells, all of which culminate in destruction of normal nephrons and their replacement by fibrous tissue. Anti-double-stranded DNA (anti-dsDNA) antibody level correlates with disease activity in most patients. There is evidence that apart from mediating pathogenic processes through the formation of immune complexes, pathogenic anti-dsDNA antibodies can bind to resident renal cells and induce downstream pro-apoptotic, pro-inflammatory, or pro-fibrotic processes or a combination of these. Recent data also highlight the critical role of macrophages in acute and chronic kidney injury. Though clinically effective, current treatments for lupus nephritis encompass non-specific immunosuppression and the anti-inflammatory action of high-dose corticosteroids. The clinical and histological impact of novel biologics targeting pro-inflammatory molecules remains to be investigated. Insight into the underlying mechanisms that induce inflammatory and fibrotic processes in the kidney of lupus nephritis could present opportunities for more specific novel treatment options to improve clinical outcomes while minimizing off-target untoward effects. This review discusses recent advances in the understanding of pathogenic mechanisms leading to inflammation and fibrosis of the kidney in lupus nephritis in the context of established standard-of-care and emerging therapies.
Data of physiological measurements and quality of life in subjects with mild to moderate COPD compared to asymptomatic current smokers, former smokers and never-smokers
Authors: Chaudhary Nveed , Luettich Karsta , Peck Michael J. , Pierri Elena , Felber-Medlin Loyse , Vuillaume Gregory , Leroy Patrice , Hoeng Julia , Peitsch Manuel C.
Published: June 2017

Chronic obstructive pulmonary disease (COPD) is a common inflammatory airway disease predominantly associated with cigarette smoking, and its incidence is increasing worldwide. According to the Global Initiative for Obstructive Lung Disease (GOLD) guidelines, spirometry is used to diagnose the disease. However, owing to its complexity, spirometry alone may not account for the multitude of COPD phenotypes or the early, asymptomatic lung damage seen in younger smokers. In addition, suitable biomarkers enabling early diagnosis, guiding treatment and estimating prognosis are still scarce, although large scale ‘omics analyses have added to the spectrum of potential biomarkers that could be used for these purposes.

The aim of the current study was to comprehensively profile patients with mild-to-moderate COPD and compare the profiles to i) a group of currently smoking asymptomatic subjects, ii) a group of healthy former smokers, and iii) a group of healthy subjects that had never smoked. The assessment was conducted at the molecular level using proteomics, transcriptomics, and lipidomics and complemented by a series of measurements of traditional and emerging indicators of lung health (ClinicalTrials.gov identifier: NCT01780298). In this data note, we provide a comprehensive description of the study population’s physiological characteristics including full lung function, lung appearance on chest computed tomography, impulse oscillometry, and exercise tolerance and quality of life (QoL) measures.
DEVELOPMENT OF LEGISLATION ON THE REGISTRATION OF POLITICAL PARTIES IN AUSTRALIA
Authors: Чурсина Татьяна , Chursina Tatyana
Published: June 2017

Nowadays it is difficult to imagine a stable political environment without the functioning of political parties in modern democracies. In order to cover new or existing political views and stimulate the formation of new parties, the legislation regulating the activities of political parties is dynamically developing. The state also creates various restrictions on the way to continue the activities of existing parties or the formation of new ones, especially in multi-party democracies, where a multiplicity of parties creates confusion for voters, and can lead to instability in the activities of the government or parliament. For the stable functioning of a political party, there is a need for clearly defined legal requirements that it must follow, and for its registration it must comply with all formalities prescribed by law, including those related to the preparation of a set of documents. These reasons determine the relevance of the problems of legal regulation of registration of political parties. All these processes are observed in Australia, where over the past 30 years have been significant reforms that entailed the legal consolidation of political parties in the electoral process. The requirement for a relatively low membership for the party registration in Australia facilitates the formation of parties that seek to solve local or regional problems, and the possibility of creating representative offices and regional affiliates of political parties contributes to defending regional and local interests without violating the state’s national integrity and unity of the system of state power, as the basis of a federal system. To register the party at the federal level and the level of a number of states, it is also possible to use the rule of “parliamentary representation”. Achieving a balance between different regimes of party registration facilitates the organization of candidates in clearly structured groups, ensuring equal conditions for political competition.
Case Article—A Prescription for Budget Woes at Gracious University Hospital
Authors: Hicklin Karen , Ivy Julie S. , Vila-Parrish Anita R.
Published: June 2017

This case study focuses on pharmacy operations from the standpoint of the chief financial officer for Gracious University Hospital. Her charge was to reduce operational expenses on top of pre-established budget cuts. Her first order of business was to handle inventory of the automated dispensing cabinets (ADCs) located on each floor of the hospital which contains a limited supply of medication supplied by the central pharmacy. In order to develop an effective inventory plan, a tiger team was developed consisting of physicians, patients, nurses, and pharmacists who developed a physical simulation competition between hospital unit floors which focused on the medication delivery process from prescription entry to medication administration. While observing the process, data would be captured and teams would attempt to derive better inventory policies for the medications kept in the ADCs. This case introduces students to healthcare operations by providing background on pharmacy medication delivery systems. The learning objectives of the case and accompanying simulation activity are to (1) explore the challenges of inventory management in healthcare (2) develop and analyze inventory policies based on data collection and observation (3) understand the impact of variability and perishability on inventory management.

An electronic companion is available at https://doi.org/10.1287/ited.2016.0159ca .
Analyst Information Discovery and Interpretation Roles: A Topic Modeling Approach
Authors: Huang Allen H. , Lehavy Reuven , Zang Amy Y. , Zheng Rong
Published: June 2017

This study examines analyst information intermediary roles using a textual analysis of analyst reports and corporate disclosures. We employ a topic modeling methodology from computational linguistic research to compare the thematic content of a large sample of analyst reports issued promptly after earnings conference calls with the content of the calls themselves. We show that analysts discuss exclusive topics beyond those from conference calls and interpret topics from conference calls. In addition, we find that investors place a greater value on new information in analyst reports when managers face greater incentives to withhold value-relevant information. Analyst interpretation is particularly valuable when the processing costs of conference call information increase. Finally, we document that investors react to analyst report content that simply confirms managers’ conference call discussions. Overall, our study shows that analysts play the information intermediary roles by discovering information beyond corporate disclosures and by clarifying and confirming corporate disclosures.

The Internet appendix is available at https://doi.org/10.1287/mnsc.2017.2751 .

This paper was accepted by Suraj Srinivasan, accounting.
Equivalent Inventory Metrics: A Behavioral Perspective
Authors: Stangl Tobias , Thonemann Ulrich W.
Published: June 2017

We analyze how performance metrics that contain equivalent information affect actual decisions. We consider two such performance metrics from supply chain management, days of supply and inventory turn rate, where one is the inverse of the other. We argue that individuals’ assessment of performance is also affected by the metric as opposed to solely based on the inventory value that actually matters. We perform three laboratory studies and analyze how decisions are affected by the metric used to indicate inventory performance. The first study considers alternative inventory optimizations, out of which one must be selected. The second study analyzes a decision maker who must decide on the effort to invest in optimizing inventory of a specific product. The third study corresponds to the economic order quantity model. Our behavioral models suggest that decisions are affected by the metric that is used to indicate performance, and we find support for the predictions in laboratory experiments with human subjects: Under the inventory turn rate metric, individuals overvalue inventory reductions. Compared to decisions under the days of supply metric, they choose worse inventory optimization options, invest more effort optimizing inventory of specific products, and choose higher ordering cost.

The e-companion is available at https://doi.org/10.1287/msom.2017.0620 .
Systematic Differences and Random Rates: Reconciling Gibrat’s Law with Firm Differences
Authors: Knudsen Thorbjørn , Levinthal Daniel A. , Winter Sidney G.
Published: June 2017

A fundamental premise of the strategy field is the existence of persistent firm-level differences in resources and capabilities. This property of heterogeneity should express itself in a variety of empirical “signatures,” such as firm performance and arguably systematic and persistent differences in firm-level growth rates, with low cost firms outpacing high cost firms. While this property of performance differences is a robust regularity, the empirical evidence on firm growth and Gibrat’s law does not support the later conjecture. Gibrat’s law, or the “law of proportionate effect,” states that, across a population of firms and over time, firm growth at any point is, on average, proportionate to size of the firm. We develop a theoretical argument that provides a reconciliation of this apparent paradox. The model implies that in early stages of an industry history. firm growth may have a systematic component, but for much of an industry’s and firm’s history should have a random pattern consistent with the Gibrat property. The intuition is as follows. In a Cournot equilibrium, firms of better “type” (i.e., lower cost) realize a larger market share, but act with some restraint on their choice of quantity in the face of a downward sloping demand curve and recognition of their impact on the market price. If firms are subject to random firm-specific shocks, then in this equilibrium setting a population of such firms would generate a pattern of growth consistent with Gibrat’s law. However, if broader evolutionary dynamics of firm entry, and the subsequent consolidation of market share and industry shake-out is considered, then during early epochs of industry evolution, one would tend to observe systematic differences in growth rates associated with firm’s competitive fitness. Thus, it is only in these settings far from industry equilibrium that we should see systematic deviations from Gibrat’s law.
Nesting sites characteristics of stingless bees (Hymenoptera: Apidae) in Central Sulawesi, Indonesia
Authors: Suriawanto Nelky , Atmowidi Tri , Kahono Sih
Published: June 2017

Stingless bees (Hymenoptera: Apidae) is eusocial insects that live together in a colony. This research was aimed to study the nesting site characteristics of stingless bees in the settlement areas at Central Sulawesi, Indonesia. The nesting sites were observed by purposive sampling method from July 2015 to January 2016. Four species belong to genus Tetragonula were found, namely T. fuscobalteata, T. biroi, T. sapiens, and T. laeviceps. Two spesies, T. biroi and T. sapiens are the new record in Sulawesi island. The highest abundance of stingless bees colony was T. fuscobalteata (92.26%), followed by T. biroi (4.17%), T. sapiens (2.98%), and T. laeviceps (0.59%). Nesting sites of T. fuscobalteata were found in the stone, brick wall, wooden wall, bamboo, and iron cavities, T. biroi in the wooden wall, stone, and brick wall cavities, T. sapiens in stone cavities, while T. laeviceps in wooden walls.
Predictors of Risky Behavior and Offending for Adolescents With Mild Intellectual Disability
Authors: Savage Melissa N. , Bouck Emily C.
Published: June 2017

Adolescents with intellectual disability (ID) engage in risky behavior and offending. However, little is known on the impact school-related predictors have on engagement in risky behaviors for adolescents with ID. This study analyzed secondary data from the National Longitudinal Transition Study-2 (NLTS2) to determine levels of engagement in risky behaviors and offending for adolescents with mild and moderate/severe ID. School-related predictors of engagement for adolescents with mild ID were also explored. Results indicated adolescents with mild ID engage in risky behaviors and offending at significantly higher rates as compared to adolescents with moderate/severe ID. Participation in a social skills or life skills class was a significant predictor of less engagement in risky behaviors for individuals with mild ID.
Parent Perspectives of Applying Mindfulness-Based Stress Reduction Strategies to Special Education
Authors: Burke Meghan M. , Chan Neilson , Neece Cameron L.
Published: June 2017

Parents of children with (versus without) intellectual and developmental disabilities report greater stress; such stress may be exacerbated by dissatisfaction with school services, poor parent-school partnerships, and the need for parent advocacy. Increasingly, mindfulness interventions have been used to reduce parent stress. However, it is unclear whether parents apply mindfulness strategies during the special education process to reduce school-related stress. To investigate whether mindfulness may reduce school-related stress, interviews were conducted with 26 parents of children with intellectual and developmental disabilities who completed a mindfulness-based stress reduction intervention. Participants were asked about their stress during meetings with the school, use of mindfulness strategies in communicating with the school, and the impact of such strategies. The majority of parent participants reported: special education meetings were stressful; they used mindfulness strategies during IEP meetings; and such strategies affected parents' perceptions of improvements in personal well-being, advocacy, family-school relationships, and access to services for their children. Implications for future research, policy, and practice are discussed.
Expressões idiomáticas em dicionários bilíngues pedagógicos francês-português brasileiro: uma análise comparativa por amostragem das letras A e P
Authors: Parreira Maria Cristina , Robayo García Maria Camila , Chrispolim Júlia Garcia
Published: June 2017

Este estudo decorre do trabalho prático da colaboração internacional com uma editora que propôs um dicionário bilíngue pedagógico contemplando a variante brasileira do português com a língua francesa. O trabalho gerou um corpus de 102 arquivos .DOC do qual foram compiladas as unidades fraseológicas em novo corpus, aqui denominado corpus Kernerman, em arquivos .XLS, contendo 2696 linhas de A a Z, das quais foram selecionadas as letras A e P. Autores como Zuluaga (1980), Corpas Pastor (1997), Xatara (1998b), Ortiz Álvares (2000), Biderman (2001, 2005), Krieger (2006), Welker (2006, 2011) e Xatara e Parreira (2011) constituíram o arcabouço teórico da pesquisa.  A análise consiste na identificação dessas unidades e no levantamento das expressões idiomáticas, para comparação quantitativa do material em dicionários bilíngues usuais no Brasil, das editoras Larousse (2005) e Melhoramentos (2002), com a hipótese de que, nos dicionários mais antigos, não há tratamento adequado dessa parcela do léxico, como os dados demonstraram ao final.
Colocações especializadas do setor feirístico
Authors: Fante Godoy Ariane Dutra
Published: June 2017

O setor feirístico tem grande relevância no cenário econômico nacional e internacional e está em constante expansão, oferecendo oportunidades para as empresas tornarem-se conhecidas, expandirem seus negócios, gerarem empregos e aumentarem as suas receitas. Esse contexto estimula o surgimento de material especializado e cria a demanda por tradução. Para esse artigo propomos apresentar alguns exemplos de colocações verbais especializadas encontradas durante pesquisa realizada no mestrado para a elaboração do Glossário Bilíngue dos Termos Fundamentais do Setor Feirístico: Busca de Equivalências em Inglês (GODOY, 2014), para o uso de profissionais da área, pesquisadores, estudantes e, principalmente, intérpretes e tradutores. Para tanto, utilizamos como base teórica os conceitos e princípios da Terminologia Bilíngue e Equivalência Terminológica (DUBUC, 1985, 1992), da Teoria Comunicativa da Terminologia (CABRÉ, 1993, 1999) e da Linguística de Corpus (SINCLAIR, 1966; BERBER SARDINHA, 2004). Para desenvolver esse trabalho, reunimos corpora em português e em inglês (livros, artigos e revistas especializados, guias e manuais do expositor). Para a coleta das colocações utilizamos o software WordSmith tools (versão 6.0), desenvolvido por Mike Scott (2012), e as armazenamos em fichas criadas com o apoio da ferramenta Access 2010. Em seguida, procedemos à análise dos contextos e dos ganchos terminológicos para a busca e o estabelecimento das equivalências. Considerando a relevância da participação em feiras para a expansão das exportações e o crescimento da economia interna, essa pesquisa será útil não só para os profissionais do setor, mas também para tradutores e intérpretes que produzem textos orais e escritos sobre o referido domínio.
Annular split level shear tester sebagai alat pengukur karakteristik aliran bahan padat butiran
Authors: Sasongko Setia Budi
Published: June 2017

Jenike Shear Tester telah dikenal dengan baik sebagai suatu instrumen untuk mengetahui sifat pengaliran dari suatu bahan padat butiran. Hasil pengukuran bahan berdasarkan Jenike Shear Tester ini telah direkomendasikan sebagai suatu standar. Akan tetapi instrument ini memiliki eberapa keterbatasan antara lain: keterbatasan untuk geseran horizontal demikian juga dengan jumlah titik untuk membuat kurve patahan, diperlukan beberapa sample untuk membuat kurve patahan, dan juga adanya ketidak uniform antara bagian yang dekat dengan cincin dengan bagian tengah cincin. Untuk mengatasi hal ini, kemudian Peshcl mengembangkan shear tester jenis totational (RO 200), akan tetapi pada kenyataan masih terdapat beberapa kelemahan. Dengan mengurangi kelemahan yang terdapat pada  Peschl Shear Tester, maka pada penelitian ini, dikembangkan Shear Tester jenis Annular Split Level dengan hasil pengukuran yang mendekati hasil Jenike Shear Tester.Keyword : Shear Tester, Rotational  Shear Tester, Annular Split Level Shear Tester
Parameter Kga- Enhancement Factor Dalam Sistem Absorbs CO2 Dengan Larutan NaOH
Authors: Hadiyanto Hadiyanto , K. Andri C. , Djaeni Moh.
Published: June 2017

Absorbsi merupakan proses perpindahan massa untuk memisahkan suatu gas dari  campurannya dengan cairan penyerap NaOH, MEA atau K2CO3. Pada penelitian ini, campuran gas yang mengandung CO2 dikontakkan dengan larutan NaOH sebagai penyerap dalam suatu kolom unggun tetap. Penelitian ini juga mempelajari pengaruh laju alir larutan NaOH sebesar 0,026-0,042 liter /detik dan suhu operasi 30-70 0C. Sedangkan tekanan, laju alir gas udara, jenis dan ukuran packing serta komposisi awal CO2 (56,8%) dijaga tetap.Analisis secara fisis dan fisis-kimia dilakukan dengan suatu model mathematic untuk menentukan koefisien perpindahan massa gas-cair (kga), enhangement factor (E) dantetapan-tetapan perancangan yang lain. Koefisien –koefisien tersebut ditentukan untuk melengkapi data-data perancangan kolom absorbs CO2, yang lebih akurat dan sesuai untuk diterapkan dalam industri.Hasil penelitian menunjukkan bahwa harga koefisien perpindahan massa (kga)untuk absorbs gas CO2 dengan NaOH dipengaruhi oleh laju alir cairan penyerap dan temperature. Semakin besar laju alir maka harga kga makin besar pula dan semakin tinggi temperatur makaharga kga juga semakin besar. Harga kga yang didapat berkisar antara 2,44x 10-2 sampai 5,77x 10-2 untuk variabel proses  T= 30-70 0C dan laju alir cairan 0,026 -0,042 l/detik. Sedangkan untuk Enhancement factor (E) berkisar antara 4,2156 sampai 7,1414.Kata kunci : Absorpsi, kga, Enhancement factor
Pemakaian Asam Askorbat Untuk Produksi Koenzim Quinine Dengan Induksi Sel Nicotiana Tabaccum
Authors: Nurdin Said , Huzaimi Afnizar
Published: June 2017

Koenzim quinine merupakan produk intraseluler nicotiana tobaccum, sehingga untuk mengisolasikannya diperlukan penambahan antioksidan. Penelitian penambahan antioksidan berupa sam askobat dengan variasi konsentrasi bertujuan untuk menyelidiki  tingkat efektifitas pemakaian senyawa tersebut  dengan proses induksi sel menurut perubahan waktu. Proses induksi berlangsung melalui penambahan inokulum ke dalam nutrient sampai terbentukkan callus. Callus dipindahkan ke dalam media pemeliharaan yang telah diberikan nutrien, sehingga tumbuh dan berkembang menjadi sel baru.  Pertumbuhan sel di dalam medium cair diamati melalui berat sel segar yang diperoleh. Perkembangan berat sel segar dan produksi koenzim quinine kasar pada berbagai konsentrasi vitamin C tersebut ditentukan dengan menggunakan HPLC dan pendeteksiannya spectrometer Shimadzu SPD-10 A pada panjang gelombang 275 nm. Hasil pembentukan koenzim quinine diuji pada hari ke- 1, 3, 5,6 dan 7 dengan konsentrasi 0,5 mg/l. nilai optimalnya dicapai sebesar 0,3598 ppm, 0,3641 ppm, 0,3675 ppm, 0,3699 ppm dan 0,3718 ppm, dan pada konsentrasi asam askorbat = 0,7 mg/l menunjukkan produksi koenzim quinine, sbanyak 0,3920 ppm, 0,3791 ppm, 0,3996 ppm, 0,4005 ppm dam 0,4030 ppm.Kata kunci : asam askorbat, antioksidan, coenzim quinine, induksi sel, nicotiana tabaccum, inokulum, nutrient, callus, medium
Pengaruh Waktu Tunggal Biomassa (SRT) Terhadap Kualitas Limbah Cair Indistri Tekstil Dengan Proses Lumpur Aktif-Membran
Authors: Suwardiyono Suwardiyono
Published: June 2017

Penelitian proses gabungan lumpur aktif- membrane ini merupakan penggabungan proses lumpur aktif konvensional, dalam rangka upaya peningkatan kinerja proses. Dalam system ini, membrane berfungsi sebagai pengganti bak sedimentasi. Proses pengolahan diharapkan bias beroprasi pada konsentrasi biomassa dan waktu tinggal iomassa yang tinggi serta menghasilkan sitem yang kompak.Pada penelitian ini digunakan limbah cair industry tekstil dengan COD 795-1148 mg/l dan mikroorganisme dari sistem proses lumpur aktif konvensional.  Proses membrane yang digunakan adalah mikrofiltrasi crossflow dengan modul hollow fiber terbuat dari polipropilen,ukuran pori 0,2 mikron dan luas permukaan membran 0,0226 m2. Proses pengolahan berlangsung pada waktu tinggal cairan  (hydraulic retention time, HRT) tetap 9 jam dan waktu tinggal lumpur ( solid retention time, SRT) divariasikan, yaitu 24, 32, 40, dan 48 hari. Dengan variasi SRT tersebut dapat diketahui pengaruh SRT terhadap kinerja proses dan kualitas keluaran.Kondisi proses membrane pada penelitian ini TMP 0,4 bar dan laju alir silang 0,88 m/s serta tekanan back backflushing 1,6 bar, selang waktu 1,5 menit dan lama back fluching 1 detik. Dengan kondisi ini, diperoleh fluks stabil 5,04 l/(jam.m2) pada berbagai SRT. Pada keadaan tunak, didapatkan MLSS semakin besar, dengan peningkatan SRT. Konsentrasi COD keluaran semakin kecil seiring dengan kenaikan SRT, yaitu pada SRT 24,32, 40 dan 48 hari berturut-turut 198, 126,79 dan 38 mg/ l. Dan efisiensi penyisihan  COD yang diperoleh semakin besar seiring dengan kenaikan SRT, yaitu pada SRT 24, 32, 40, dan 48 hari berturut-turut 80,85%; 87,59%; 92,08% dan 96,26%.Kata kunci : kualitas limbah, limbah cair, proses lumpur aktif-membran, waktu tinggal biomassa (solid retention time, SRT)
Pemanfaatan Hati Dan Biji Kapuk Serta Asam Lemak Bebas Untuk Pembuatan Sabun Lunak
Authors: Pandia Setiaty
Published: June 2017

Hati dan biji kapuk dapat dimanfaatkan sebagai basa alternatif, demikian pula asam lemak bebas (ALB) sebagai sumber lemak untuk pembuatan sabun lunak. Perlakuan awal dilakukan terhadap basa dari hati dan biji kapuk berupa pemisahan K dan Na, demikian pula dengan sumber lemak dari asam lemak bebas melalui tahap proses hidrogenasi asam lemak tak jenuhnya.Dengan memvariasikan jumlah basa dan lemak yang digunakan, pada kondisi pembakaran 400 0C, waktu perendaman 18 hari, rasio massa abu hasil pembakaran dengan air sebesar 1 : 1 serta campuran basa (16 gram kristal KOH dan 10 gram ekstrak basa) dengan 80 gram asam lemak bebas dan 5,5 gram H2O2, diperoleh sabun lunak dengan kandungan alkali bebas 0,12%, lemak tak tersabunkan 2,45% asam lemak bebas 88,3% serta pH 7,07. Kata kunci : Asam Lemak Bebas (ALB), hati dan biji kapuk, hidrogenasi, pembakaran dan ekstraksi, sabun lunak, saponifikasi
The moving-slab Heating in the furnace for various production plans
Authors: Istadi Istadi , Bindar Y. , Koswara Koswara
Published: June 2017

The reheating furnace in occasional production time has to be charged with slabs having fifferent sizes in length, ridth and thickness. This production plan was put due to economical and productivity consideration. Moreover in the future development, the slab grade might be improved to hight grades. It is our expectation that the furnace can be fire for different production plans above. The strategy for firing the burners from zone to zone has to  be determined precisely to meet the designed heating curves for the various slab. A suggest to guide in the formulations of the furnace firing strategy was developed in this work. This suggestion is based on three-dimentional mathematical model for heated slab in the furnace. This mathematical model was coded  for the computational simulation. The  code was able to simulate  furnacthree-dimentional effect of fuenace operational parameters and variety of slab length group. The result reasonably represent the slab-heating curve for different operational parameters. Unsymmetrical firing practices can be shown their effect to the 3D temperature distribution of the slab. Keywords : 3Dtemperature distribution, reheating furnace, slab heating, slab length group
Pemodelan Dan Studi Eksperimental Laju Alir Fluida Pada Fluidisasi Minimum
Authors: Diyono Diyono , Suherman Suherman
Published: June 2017

Laju alir fluida pada fluidisasi minimum telah ditelaah dengan pendekatan persamaan Ergun. Pada penelitian ini, laju alir fluida pada fluidisasi minimum ditelaah secara langsung dengan memvariasikan densitas partikel, diameter partikel dan tinggi unggun. Partikel padat yang digunakan adalah batu bara, batu bata, abu gosok, batu kapur, pasir dan zeolit sebagai representasi densitas. Diameter partikel berkisar rata-rata 0,054-0,338 mm. densitas partikel berkisar 1-3 gr/cm3. Tinggi unggun berkisar 5-10 cm. sedangkan fluida pembawanya adalah udara. Laju alir fluida pada fluidisasi minimum mengalami kenaikan seiring naiknya densitas partikel, diameter partikel dan tinggi unggun model persamaan matematis yang diperoleh adalah bentuk fungsi eksponensial dari kelompok-kelompok bilangan tak berdimensi dimana laju alir fluida pada fluidisasi minimum tergabung dalam kelompok bilangan Reynold. Hasil prediksi model memberikan hasil yang cukup baik bila dibandingkan dengan data eksperimental. Kata kunci : fluidisasi minimum, laju alir fluida
Stigmas and Memory of Slavery in West Africa: Skin Color and Blood as Social Fracture Lines
Authors: Thioub Ibrahima
Published: June 2017

The campaign and eventual abolition of the African slave was momentous on several levels, not least for its impact on the global economy. In Africa itself, it brought about constant conflict. This article traces the ambiguities of the anti-slavery struggle on the part of the colonial powers, with a main emphasis on French colonies. It then proceeds to explore the legacies of slavery in several of these societies before reaching some broader conclusions about the contemporary discourse of legitimacy and memory.
Comparative Analysis of Business Process Modelling Tools for Compliance Management Support
Authors: Koncevičs Rolands , Peņicina Ludmila , Gaidukovs Andrejs , Darģis Māris , Burbo Rita , Auziņš Ainārs
Published: June 2017

The paper presents results of the comparative analysis of business process modelling tools for supporting automated compliance management in organisations. By compliance in the paper we mean compliance to legislation, regulations of municipalities, external regulatory requirements and also internal organisational policies. The goal of the research is (1) to identify main attributes of business process modelling tools relevant in compliance management, and (2) to use the identified attributes for analysis of the tools to better understand the scope of their capability to support compliance management. The attributes of the tools have been derived from the related research. The analysis of the tools has been performed by installing each tool and evaluating it against a set of the identified attributes. The obtained results are useful in choosing the tools for compliance management in general and for open source solutions to develop new compliance management tools in particular.
Coordinator Role Mobility Method for Increasing the Life Expectancy of Wireless Sensor Networks
Authors: Jurenoks Aleksejs , Jokićb Dejan
Published: June 2017

The general problem of wireless sensor network nodes is the low-power batteries that significantly limit the life expectancy of a network. Nowadays the technical solutions related to energy resource management are being rapidly developed and integrated into the daily lives of people. The energy resource management systems use sensor networks for receiving and processing information during the realia time. The present paper proposes using a coordinator role mobility method for controlling the routing processes for energy balancing in nodes, which provides dynamic network reconfiguration possibilities. The method is designed to operate fully in the background and can be integrated into any exiting working system.
Various Methods of Knowledge Assessment during the Training of IT Specialists
Authors: Zaiceva Larisa , Prokofjeva Natālija , Kataļņikova Sabina
Published: June 2017

Nowadays requirements for training of qualified IT specialists constantly increase. These issues as well as possible solutions are discussed by both teachers and students on many seminars, forums and conferences. The paper studies different methods of students′ knowledge control and computer systems that are used at the Faculty of Computer Science and Information Technology of Riga Technical University and demonstrates results of computer based students’ knowledge control use. Since 2005, two experiments have been held at the Department of Software Engineering in order to evaluate the efficiency of e-course application. The aim of the study is to determine how the use of e-courses for the control of knowledge affects the quality of education during the course studies given that students do not perform all the control activities. The results have shown that the highest examination results are achieved by the students who have completed all the control activities. It proves the influence of use of e-courses for knowledge control on quality of education.
Nutritional status among children and adolescents aged 6–18 years of Kolam tribe of Andhra Pradesh, India
Authors: Bharthi K. , Ghritlahre Manisha , Das Subal , Bose Kaushik
Published: June 2017

Malnutrition has become one of the serious problems among children and adolescents internationally, especially in developing countries. India, a developing country covers 40% of undernourished children of the world. In India, tribal population is among the most deprived and undernourished people. The present study shows the prevalence of undernutrition among Kolam tribal children and adolescents by comparing different Body Mass Index (BMI) cut off points. Age and sex specific nutritional status of studied population shows 15.01% boys and 18.35% girls are in Chronic Energy Deficiency (CED) III category, 16.22% boys and 19.32% girls are in CEDII, 31.71% boys and 2.72% girls are in CEDI only 0.96% boys and 1.69% girls are in overweight category respectively. Undernutrition is not limited to young children, even adults are also severely underweight in developing countries. Health and nutrition of today’s adolescent girls may have great impact on the quality of next generation. Proper nutritional programs and health policies are needed to be implemented among tribals to solve the problem of undernutrition and similar studies should be planned in other underprivileged sections worldwide.
Association between body size and selected hematological parameters in men and women aged 45 and above from a hospitalized population of older adults: an insight from the Polish Longitudinal Study of Aging (1960–2000)
Authors: Chmielewski Piotr , Strzelec Bartłomiej , Chmielowiec Jolanta , Chmielowiec Krzysztof , Borysławski Krzysztof
Published: June 2017

In elderly people, anemia occurs with increasing frequency with each advancing decade and can be a harbinger of very serious health conditions, including gastrointestinal bleeding, gastric and duodenal ulcers, and cancer. Therefore, age-dependant changes in hematological parameters deserve special attention. Nonetheless, very few longitudinal studies of aging have focused on possible associations between basic anthropometric characteristics and hematological parameters in older people. Here, we present some evidence that body size can be associated with red blood cell count as well as some other selected hematological parameters in adults aged 45 to 70 years. Longitudinal data on anthropometric and hematological parameters have been obtained from physically healthy residents at the Regional Psychiatric Hospital for People with Mental Disorders in Cibórz, Lubuskie Province, Poland (142 individuals, including 68 men and 74 women). The residents who took psychoactive drugs were excluded from the study. To evaluate the studied relationships, three anthropometric traits were used and three dichotomous divisions of the study sample were made. The medians of body height, body weight, and body mass index at the age of 45 years were used to divide the sample into: shorter and taller, lighter and heavier, and slimmer and stouter individuals, respectively. Student’s t-test, Pearson’s correlation, and regression analysis were employed. The results of the present study suggest that the relationship between body size and red blood cell count is slightly more pronounced in men and its strength depends on age. However, the correlations between body size and red blood cell count proved to be weak in both sexes. With aging, the strength of the relation decreased gradually, which might have been caused by the aging-associated changes in the hematopoietic system, anemia, or was an artifact. Further studies are needed to elucidate the unclear association between body size and hematological parameters in older adults.
Study of skin of an Egyptian mummy using a scanning electron microscope
Authors: Mańkowska-Pliszka Hanna , Przychodzeń Halina , Nawrot Michał , Tarka Sylwia , Wasylczyk Piotr , Dąbkowska Agnieszka , Fudalej Marcin , Rzeźnicka Ewa , Haładaj Dagmara , Pliszka Aleksandra
Published: June 2017

The first study of modified human remains using an electron microscope was carried out at the end of the 1950 and in 1979 the first result of the study involving a scanning electron microscope (SEM) was published for the first time. The study was mainly focused on the structure of tissues and cells. With the help of this technique cell and tissue elements, viruses and bacterial endospores as well as the structure of epithelium and the collagen contents of dermis were identified and described. In the above-mentioned case the object of the study using a SEM was a free part of the right hand (forearm with the dorsal and palmar parts of hand) of unknown origin, with signs of mummification revealed during microscopic analysis. Our study was aimed at finding the answer to the question if the mummification of the studied limb was natural or intentional, and if the study using a SEM could link the anonymous remains with ancient Egypt.