bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical practice guidelines on the evidence‐based use of integrative therapies during and after breast cancer treatment
Authors: Greenlee Heather , DuPont‐Reyes Melissa J. , Balneaves Lynda G. , Carlson Linda E. , Cohen Misha R. , Deng Gary , Johnson Jillian A. , Mumber Matthew , Seely Dugald , Zick Suzanna M. , Boyce Lindsay M. , Tripathy Debu
Published: April 2017

Answer questions and earn CME/CNE

Patients with breast cancer commonly use complementary and integrative therapies as supportive care during cancer treatment and to manage treatment‐related side effects. However, evidence supporting the use of such therapies in the oncology setting is limited. This report provides updated clinical practice guidelines from the Society for Integrative Oncology on the use of integrative therapies for specific clinical indications during and after breast cancer treatment, including anxiety/stress, depression/mood disorders, fatigue, quality of life/physical functioning, chemotherapy‐induced nausea and vomiting, lymphedema, chemotherapy‐induced peripheral neuropathy, pain, and sleep disturbance. Clinical practice guidelines are based on a systematic literature review from 1990 through 2015. Music therapy, meditation, stress management, and yoga are recommended for anxiety/stress reduction. Meditation, relaxation, yoga, massage, and music therapy are recommended for depression/mood disorders. Meditation and yoga are recommended to improve quality of life. Acupressure and acupuncture are recommended for reducing chemotherapy‐induced nausea and vomiting. Acetyl‐L‐carnitine is not recommended to prevent chemotherapy‐induced peripheral neuropathy due to a possibility of harm. No strong evidence supports the use of ingested dietary supplements to manage breast cancer treatment‐related side effects. In summary, there is a growing body of evidence supporting the use of integrative therapies, especially mind‐body therapies, as effective supportive care strategies during breast cancer treatment. Many integrative practices, however, remain understudied, with insufficient evidence to be definitively recommended or avoided. CA Cancer J Clin 2017;67:194–232. © 2017 American Cancer Society.
Maternal and Newborn Health Care Practices in Rural Bangladesh
Authors: Ansari Md Mostaque Hossain , Biswas Sailendra Nath , Hussain Rubaiyat Farzana , Ripon Shariful Hasan , Hossain M Nazmul
Published: April 2017

Maternal and child health indicators have improved in Bangladesh but still pregnancy and child birth related complications are the leading causes of death of mother and children. Practices associated with these mortality reductions are not followed similarly throughout the country. This descriptive study was carried out to examine the prevalence of maternal and newborn-care practices in the rural area of Bangladesh. Face to face interview was conducted to collect data using closed end questionnaire from the purposively selected 589 women of reproductive age having at least one child. SPSS version 16 software was used for computation and analysis of data. Among the respondents, 58.4% received ANC visits but only 32.3% had completed minimum required visits ( 3). Effective immunization of mothers against tetanus was 93.3%. Home delivery incidence was 72.3 % and 92.2% of all deliveries were attended by trained health professionals. Only 17.0% got PNC visits. Birth weight recording coverage was only 34.5%. Maternal and newborn health care practices could not be eulogized for low coverage of ANC, PNC, birth weight recording and high incidence of home delivery. Recommendations were made to improve the quality of MCH service and service providers and to strengthen the motivational program for community participation.KYAMC Journal Vol. 5, No.-1, Jul 2014, Page 453-457
Study of Body Mass Index (BMI) on Medical Students
Authors: Akhter Hafiza , Jahan Nasim , Jahan Nasim , Mahmud Fazle , Mahmud Fazle , Sultana Nayma , Sultana Nayma , Ferdous Tabassum , Ferdous Tabassum , Akhter Hasina , Akhter Hasina
Published: April 2017

Background: Body mass index is a valuable tool to assess the nutritional status of an individual. It can be conveniently used to identify those who are underweight, overweight or obese.Objective: To determine the BMI status of medical students.Methods: This cross sectional descriptive study was carried out in the Department of Physiology, Sir Salimullah Medical College, Dhaka from July 2009 to June 2010. A total number of 264 students of both sexes, age ranged from 19 to 21 years were included. A structured questionnaire was used to collect and record the information on age, sex, height in meters and weight in kilograms of each subject. The measurements were taken under supervision using a standardized weighing machine, height measuring scale and measuring tape. Body Mass Index (BMI) was calculated using the formula weight (in kilogram)/ height2 (in meter). Using cut off points from World Health Organization (WHO) criteria BMI was classified. Statistical analysis was done by using SPSS version 16.Result: Mean BMI of male students was 21.64 and of female students was 23.52. In this study, the prevalence of overweight was 20.5% and obesity was 4.5% while 63.6% of the students were within normal weight range and 11.3% were underweight. Among the male students 9.35% were underweight, 76.97% were normal weight, 10.07% were overweight, 3.59% were obese and among female students it was 13.6%, 48.8%, 32% and 4.54% respectively.Conclusion: This study reveals that overweight is a rising problem for both male and female medical students. Moreover, overweight and underweight issues are more common in female students.KYAMC Journal Vol. 5, No.-1, Jul 2014, Page 472-475
Hydatid cyst of the submandibular region
Authors: Hossain Mohd Farid , Rahman Masudar , Amin Ruhul , Ahmed Tanvir , Karmaker Apu
Published: April 2017

Hydatid cyst is caused by larval stage of Echinococcus parasite, mainly/largely by E. granulosus. It usually involves one organ. It may affect many organs also. Hydatid cyst of the head and neck region is uncommon and involvement of submandibular region is very rare. Here we present a case of left submandibular region hydatid cyst. This patient is an elderly gentleman of age 61 years from Soydabad, Sirajgonj. He noticed a painless peanut size swelling in his left submandibular region 5 years back. It had started increasing in size for last 4 months and become cricket ball size. Examination revealed a soft, nontender lump in that region. Skin and subcutaneous tissues are free of lump adherence. Chest X-ray was unremarkable. CT Scan showed a benign cystic swelling. Excision was performed and pathological examination revealed a hydatid cyst.KYAMC Journal Vol. 5, No.-1, Jul 2014, Page 480-483
Lutembacher's Syndrome - A Case Report
Authors: Kabir Md Mainul , Rahman Md Lutfar , Badruzzaman Md , Islam Md Saiful , Mokhlesuzzaman -
Published: April 2017

Lutembacher's Syndrome is a rare heart disease first described by Lutembacher, is a combination of a congenital atrial septal defect (ASD) and acquired mitral stenosis (MS). Traditionally Lutembacher syndrome has been corrected by surgical treatment. If diagnosis could be done earlier, surgical closure of ASD with replacement of mitral valve bears a good prognostic value. Cases were reported where patients treated percutaneouly with a combined Inoue balloon valvuloplasty and septal defect closure using the Amplatzer septal occlusion device. Our patient Mrs. Kohinoor Begum, 26 years old, non diabetic, non hypertensive, admitted in khwaja Yunus Ali Medical College & Hospital (KYAMCH) on 03.04.2013 with the complaints of respiratory distress and chest pain for 3 years. There was history of recurrent attack of fever in childhood. Subsequently she developed MS from Rheumatic carditis. ASD was congenital in origin. After thorough perioperative evaluation pericardial patch closure of ASD with open mitral commissurotomy was done. Postoperative followup 6 months after operation showed no residual shunt with adequately functioning mitral valve.KYAMC Journal Vol. 5, No.-1, Jul 2014, Page 484-487
Organic No-Till Systems in Eastern Canada: A Review
Authors: Halde Caroline , Gagné Samuel , Charles Anaïs , Lawley Yvonne
Published: April 2017

For more than a decade, studies have aimed to adapt the agronomy of organic no-till systems for the environmental conditions of Eastern Canada. Most research on organic no-till practices in Eastern Canada has been conducted in the province of Québec, where 4% of farms are certified organic, and results from these trials have been published in technical reports available in French. The objective of this review was to revisit previous research work on organic farming in Eastern Canada—the majority of which has been published as technical reports in the French language—in order to highlight important findings and to identify information gaps. Cover crop-based rotational no-till systems for organic grain and horticultural cropping systems will be the main focus of this review. Overall, a few trials have demonstrated that organic rotational no-till can be successful and profitable in warmer and more productive regions of Eastern Canada, but its success can vary over years. The variability in the success of organic rotational no-till systems is the reason for the slow adoption of the system by organic farmers. On-going research focuses on breeding early-maturing fall rye, and terminating cover crops and weeds with the use of bioherbicides.
A Scenario-Adaptive Driving Behavior Prediction Approach to Urban Autonomous Driving
Authors: Geng Xinli , Liang Huawei , Yu Biao , Zhao Pan , He Liuwei , Huang Rulin
Published: April 2017

Driving through dynamically changing traffic scenarios is a highly challenging task for autonomous vehicles, especially on urban roadways. Prediction of surrounding vehicles’ driving behaviors plays a crucial role in autonomous vehicles. Most traditional driving behavior prediction models work only for a specific traffic scenario and cannot be adapted to different scenarios. In addition, priori driving knowledge was never considered sufficiently. This study proposes a novel scenario-adaptive approach to solve these problems. A novel ontology model was developed to model traffic scenarios. Continuous features of driving behavior were learned by Hidden Markov Models (HMMs). Then, a knowledge base was constructed to specify the model adaptation strategies and store priori probabilities based on the scenario’s characteristics. Finally, the target vehicle’s future behavior was predicted considering both a posteriori probabilities and a priori probabilities. The proposed approach was sufficiently evaluated with a real autonomous vehicle. The application scope of traditional models can be extended to a variety of scenarios, while the prediction performance can be improved by the consideration of priori knowledge. For lane-changing behaviors, the prediction time horizon can be extended by up to 56% (0.76 s) on average. Meanwhile, long-term prediction precision can be enhanced by over 26%.
An Investigation on Eddy Current Pulsed Thermography to Detect Surface Cracks on the Tungsten Carbide Matrix of Polycrystalline Diamond Compact Bit
Authors: Xu Changhang , Gong Xumei , Zhang Wuyang , Chen Guoming
Published: April 2017

Polycrystalline diamond compact (PDC) bits are commonly used drill bits in the petroleum drilling industry. Cracks often occur on the surface of a bit, which may result in the unexpected suspension of the drilling operation, or even accidents. Therefore, the detection of surface cracks on PDC bits is of great importance to ensure continuous drilling operation and to prevent accidents. However, it is extremely difficult to detect such cracks by visual inspection or other traditional nondestructive testing (NDT) techniques due to the small size of cracks and the irregular geometry of bits. As one emerging NDT technique, eddy current pulsed thermography (ECPT) can instantly detect surface cracks on metal parts with irregular geometry. In this study, the feasibility of ECPT of detecting surface cracks on the tungsten carbide matrix of PDC bits was investigated. A successive scanning detection mode is proposed to detect surface cracks by using ECPT with a low power heating excitation unit and small-size coils. The influence of excitation duration on the detection result was also investigated. In addition, principal component analysis (PCA) was employed to process the acquired IR image sequences to improve detection sensitivity. Finally, the whole shape of a crack was restored with processed images containing varied cracks segments. Based on the experimental results, we conclude that the surface cracks on the tungsten carbide matrix of PDC bit can be detected effectively and conveniently by ECPT in scanning mode with the aid of PCA.
Application of Convective Condensation Level Limiter in Convective Boundary Layer Height Retrieval Based on Lidar Data
Authors: Li Hong , Yang Yi , Hu Xiao-Ming , Huang Zhongwei , Wang Guoyin , Zhang Beidou
Published: April 2017

Micro pulse lidar is a promising tool for retrieving the convective boundary layer height (CBLH), but its application has been hindered by sharp extinction of the signal in high humidity conditions, e.g., clouds. To remedy this, we developed an effective and simple limiter to obtain more accurate estimates of the CBLH. The limiter is based on the algorithm for the convective condensation level (CCL) and is aimed at limiting the vertical extent of the lidar backscatter profile used in lidar methods to search for the CBLH. Four lidar methods (i.e., the gradient method, the idealized backscatter method, and two forms of the wavelet covariance methods) are used to calculate the CBLH with (or without) the limiter added. Compared to the CBLH calculated by the parcel method from microwave radiometer temperature data, more accurate retrieval of the CBLH is carried out with the limiter applied in four cloudy cases.
Multivariate Extended Gamma Distribution
Authors: Joseph Dhannya
Published: April 2017

In this paper, I consider multivariate analogues of the extended gamma density, which will provide multivariate extensions to Tsallis statistics and superstatistics. By making use of the pathway parameter β , multivariate generalized gamma density can be obtained from the model considered here. Some of its special cases and limiting cases are also mentioned. Conditional density, best predictor function, regression theory, etc., connected with this model are also introduced.
Projections of Future Suitable Bioclimatic Conditions of Parthenogenetic Whiptails
Authors: Alvarez Guillermo , Salas Eric , Harings Nicole , Boykin Kenneth
Published: April 2017

This paper highlights the results of bioclimatic-envelope modeling of whiptail lizards belonging to the Aspidoscelis tesselata species group and related species. We utilized five species distribution models (SDM) including Generalized Linear Model, Random Forest, Boosted Regression Tree, Maxent and Multivariate Adaptive Regression Splines to develop the present day distributions of the species based on climate-driven models alone. We then projected future distributions of whiptails using data from four climate models run according to two greenhouse gas concentration scenarios (RCP 4.5 and RCP 8.5). Results of A. tesselata species group suggested that climate change will negatively affect the bioclimatic habitat and distribution of some species, while projecting gains in suitability for others. Furthermore, when the species group was analyzed together, climate projections changed for some species compared to when they were analyzed alone, suggesting significant loss of syntopic areas where suitable climatic conditions for more than two species would persist. In other words, syntopy within members of the species group will be drastically reduced according to future bioclimatic suitability projections in this study.
Citizen Science and Topology of Mind: Complexity, Computation and Criticality in Data-Driven Exploration of Open Complex Systems
Authors: Funabashi Masatoshi
Published: April 2017

Recently emerging data-driven citizen sciences need to harness an increasing amount of massive data with varying quality. This paper develops essential theoretical frameworks, example models, and a general definition of complexity measure, and examines its computational complexity for an interactive data-driven citizen science within the context of guided self-organization. We first define a conceptual model that incorporates the quality of observation in terms of accuracy and reproducibility, ranging between subjectivity, inter-subjectivity, and objectivity. Next, we examine the database’s algebraic and topological structure in relation to informational complexity measures, and evaluate its computational complexities with respect to an exhaustive optimization. Conjectures of criticality are obtained on the self-organizing processes of observation and dynamical model development. Example analysis is demonstrated with the use of biodiversity assessment database—the process that inevitably involves human subjectivity for management within open complex systems.
Carnot-Like Heat Engines Versus Low-Dissipation Models
Authors: Gonzalez-Ayala Julian , Roco José , Medina Alejandro , Calvo Hernández Antonio
Published: April 2017

In this paper, a comparison between two well-known finite time heat engine models is presented: the Carnot-like heat engine based on specific heat transfer laws between the cyclic system and the external heat baths and the Low-Dissipation model where irreversibilities are taken into account by explicit entropy generation laws. We analyze the mathematical relation between the natural variables of both models and from this the resulting thermodynamic implications. Among them, particular emphasis has been placed on the physical consistency between the heat leak and time evolution on the one side, and between parabolic and loop-like behaviors of the parametric power-efficiency plots. A detailed analysis for different heat transfer laws in the Carnot-like model in terms of the maximum power efficiencies given by the Low-Dissipation model is also presented.
Slow Dynamics and Structure of Supercooled Water in Confinement
Authors: Camisasca Gaia , De Marzio Margherita , Rovere Mauro , Gallo Paola
Published: April 2017

We review our simulation results on properties of supercooled confined water. We consider two situations: water confined in a hydrophilic pore that mimics an MCM-41 environment and water at interface with a protein. The behavior upon cooling of the α relaxation of water in both environments is well interpreted in terms of the Mode Coupling Theory of glassy dynamics. Moreover, we find a crossover from a fragile to a strong regime. We relate this crossover to the crossing of the Widom line emanating from the liquid-liquid critical point, and in confinement we connect this crossover also to a crossover of the two body excess entropy of water upon cooling. Hydration water exhibits a second, distinctly slower relaxation caused by its dynamical coupling with the protein. The crossover upon cooling of this long relaxation is related to the protein dynamics.
PTC Self-Heating Experiments and Thermal Modeling of Lithium-Ion Battery Pack in Electric Vehicles
Authors: Zhang Chengning , Jin Xin , Li Junqiu
Published: April 2017

This paper proposes a positive temperature coefficient (PTC) self-heating method, in which EVs can be operated independently of external power source at low temperature, with a lithium-ion battery (LIB) pack discharging electricity to provide PTC material with power. Three comparative heating experiments have been carried out respectively. With charge/discharge tests implemented, results demonstrate the superiority of the self-heating method, proving that the discharge capability, especially the discharge capacity of the self-heated pack is better than that of the external power heated pack. In order to evaluate the heating effect of this method, further studies are conducted on temperature distribution uniformity in the heated pack. Firstly, a geometric model is established, and heat-generation rate of PTC materials and LIB are calculated. Then, thermal characteristics of the self-heating experiment processes are numerically simulated, validating the accuracy of our modeling and confirming that temperature distributions inside the pack after heating are kept in good uniformity. Therefore, the PTC self-heating method is verified to have a significant effect on the improvement of performance of LIB at low temperature.
Performance Comparison between Selected Evaporative Air Coolers
Authors: Pandelidis Demis , Anisimov Sergey , Drąg Paweł
Published: April 2017

The aim of this study is to determine which of the heat exchangers is characterized by the highest efficiency in different applications. Various types of evaporative air coolers were compared: a typical counter-flow unit, the same unit operating as a heat recovery exchanger, a regenerative unit and a novel, modified regenerative exchanger. The analysis includes comparing the work of evaporative heat exchangers during summer and winter season. The analysis is based on the original mathematical models. The numerical models are based on the modified ε-NTU (number of heat transfer units) method. It was established that selected arrangements of the presented exchangers are characterized by the different efficiency in different air-conditioning applications. The analysis faces the main construction aspects of those evaporative coolers and also compares two above-mentioned devices with modified regenerative air cooler, which can partly operate on cooled outdoor airflow and on the exhaust air from conditioned spaces. This solution can be applied in any climate and it is less dependent on the outdoor conditions. The second part of the study focuses on winter season and the potential of recovering heat with the same exchangers, but with dry working air channels. This allows establishing their total potential of generating energy savings during the annual operation.
Heat Roadmap Europe: Large-Scale Electric Heat Pumps in District Heating Systems
Authors: David Andrei , Mathiesen Brian Vad , Averfalk Helge , Werner Sven , Lund Henrik
Published: April 2017

The Heat Roadmap Europe (HRE) studies estimated a potential increase of the district heating (DH) share to 50% of the entire heat demand by 2050, with approximately 25–30% of it being supplied using large-scale electric heat pumps. This study builds on this potential and aims to document that such developments can begin now with technologies currently available. We present a database and the status of the technology and its ability of expansion to other European locations by reviewing experiences aimed at further research or application in the heating industry. This is based on a survey of the existing capacity of electric large-scale heat pumps with more than 1 MW thermal output, operating in European DH systems. The survey is the first database of its kind containing the technical characteristics of these heat pumps, and provides the basis for the analysis of this paper. By quantifying the heat sources, refrigerants, efficiency and types of operation of 149 units with 1580 MW of thermal output, the study further uses this data to analyze if the deployment of this technology on a large-scale is possible in other locations in Europe. It finally demonstrates that the technical level of the existing heat pumps is mature enough to make them suitable for replication in other locations in Europe.
Traditional and Novel Indicators of Climate Change Impacts on European Forest Trees
Authors: Bussotti Filippo , Pollastrini Martina
Published: April 2017

The concern for the fate of forest ecosystems under climate change demands the development of a prompt and effective system for detecting the impacts of pressure factors, such as rising temperatures, drought conditions, and extreme climatic events. In ongoing European monitoring programs, the health condition of trees is only assessed visually as a matter of course and there is limited evidence that enhanced crown defoliation implies physiological disturbance and reduced tree growth. The progress of the research makes it possible to apply methods developed in experimental conditions in forests for the fast and reliable assessment of impacts and of stress conditions. In this review, we analyze the most promising indicators of tree and forest health (at individual plant and ecosystem levels) for their potential application in forest ecosystems and their ability to support and integrate the traditional visual assessment, provide information on influential factors, and improve the prediction of stand dynamics and forest productivity.
Gene Expression Analysis before and after Treatment with Adalimumab in Patients with Ankylosing Spondylitis Identifies Molecular Pathways Associated with Response to Therapy
Authors: Dolcino Marzia , Tinazzi Elisa , Pelosi Andrea , Patuzzo Giuseppe , Moretta Francesca , Lunardi Claudio , Puccetti Antonio
Published: April 2017

The etiology of Ankylosing spondylitis (AS) is still unknown and the identification of the involved molecular pathogenetic pathways is a current challenge in the study of the disease. Adalimumab (ADA), an anti-tumor necrosis factor (TNF)-alpha agent, is used in the treatment of AS. We aimed at identifying pathogenetic pathways modified by ADA in patients with a good response to the treatment. Gene expression analysis of Peripheral Blood Cells (PBC) from six responders and four not responder patients was performed before and after treatment. Differentially expressed genes (DEGs) were submitted to functional enrichment analysis and network analysis, followed by modules selection. Most of the DEGs were involved in signaling pathways and in immune response. We identified three modules that were mostly impacted by ADA therapy and included genes involved in mitogen activated protein (MAP) kinase, wingless related integration site (Wnt), fibroblast growth factor (FGF) receptor, and Toll-like receptor (TCR) signaling. A separate analysis showed that a higher percentage of DEGs was modified by ADA in responders (44%) compared to non-responders (12%). Moreover, only in the responder group, TNF, Wnt, TLRs and type I interferon signaling were corrected by the treatment. We hypothesize that these pathways are strongly associated to AS pathogenesis and that they might be considered as possible targets of new drugs in the treatment of AS.
Fat Mass Is Positively Associated with Estimated Hip Bone Strength among Chinese Men Aged 50 Years and above with Low Levels of Lean Mass
Authors: Han Guiyuan , Chen Yu-Ming , Huang Hua , Chen Zhanyong , Jing Lipeng , Xiao Su-Mei
Published: April 2017

This study investigated the relationships of fat mass (FM) and lean mass (LM) with estimated hip bone strength in Chinese men aged 50–80 years (median value: 62.0 years). A cross-sectional study including 889 men was conducted in Guangzhou, China. Body composition and hip bone parameters were generated by dual-energy X-ray absorptiometry (DXA). The relationships of the LM index (LMI) and the FM index (FMI) with bone phenotypes were detected by generalised additive models and multiple linear regression. The associations between the FMI and the bone variables in LMI tertiles were further analysed. The FMI possessed a linear relationship with greater estimated hip bone strength after adjustment for the potential confounders (p < 0.05). Linear relationships were also observed for the LMI with most bone phenotypes, except for the cross-sectional area (p < 0.05). The contribution of the LMI (4.0%–12.8%) was greater than that of the FMI (2.0%–5.7%). The associations between the FMI and bone phenotypes became weaker after controlling for LMI. Further analyses showed that estimated bone strength ascended with FMI in the lowest LMI tertile (p < 0.05), but not in the subgroups with a higher LMI. This study suggested that LM played a critical role in bone health in middle-aged and elderly Chinese men, and that the maintenance of adequate FM could help to promote bone acquisition in relatively thin men.
Commitment of Scaffold Proteins in the Onco-Biology of Human Colorectal Cancer and Liver Metastases after Oxaliplatin-Based Chemotherapy
Authors: Rotoli Deborah , Morales Manuel , Ávila Julio , Maeso María , García María , Mobasheri Ali , Martín-Vasallo Pablo
Published: April 2017

Scaffold proteins play pivotal roles in the regulation of signaling pathways, integrating external and internal stimuli to various cellular outputs. We report the pattern of cellular and subcellular expression of scaffoldins angiomotin-like 2 (AmotL2), FK506 binding protein 5 (FKBP51) and IQ motif containing GTPase-activating protein 1 (IQGAP1) in colorectal cancer (CRC) and metastases in liver resected after oxaliplatin-based chemotherapy (CT). Positive immunostaining for the three scaffoldins was found in most cells in healthy colon, tumor, healthy liver and metastasized liver. The patterns of expression of AmotL2, FKBP51 and IQGAP1 show the greatest variability in immune system cells and neurons and glia cells and the least in blood vessel cells. The simultaneous subcellular localization in tumor cells and other cell types within the tumor suggest an involvement of these three scaffoldins in cancer biology, including a role in Epithelial Mesenchymal Transition. The display in differential localization and quantitative expression of AmotL2, FKBP51, and IQGAP1 could be used as biomarkers for more accurate tumor staging and as potential targets for anti-cancer therapeutics by blocking or slowing down their interconnecting functions. Tough further research needs to be done in order to improve these assessments.
E2/ER β Enhances Calcineurin Protein Degradation and PI3K/Akt/MDM2 Signal Transduction to Inhibit ISO-Induced Myocardial Cell Apoptosis
Authors: Lin Kuan-Ho , Kuo Wei-Wen , Shibu Marthandam , Day Cecilia-Hsuan , Hsieh You-Liang , Chung Li-Chin , Chen Ray-Jade , Wen Su-Ying , Viswanadha Vijaya , Huang Chih-Yang
Published: April 2017

Secretion of multifunctional estrogen and its receptor has been widely considered as the reason for markedly higher frequency of heart disease in men than in women. 17β-Estradiol (E2), for instance, has been reported to prevent development of cardiac apoptosis via activation of estrogen receptors (ERs). In addition, protein phosphatase such as protein phosphatase 1 (PP1) and calcineurin (PP2B) are also involved in cardiac hypertrophy and cell apoptosis signaling. However, the mechanism by which E2/ERβ suppresses apoptosis is not fully understood, and the role of protein phosphatase in E2/ERβ action also needs further investigation. In this study, we observed that E2/ERβ inhibited isoproterenol (ISO)-induced myocardial cell apoptosis, cytochrome c release and downstream apoptotic markers. Moreover, we found that E2/ERβ blocks ISO-induced apoptosis in H9c2 cells through the enhancement of calcineurin protein degradation through PI3K/Akt/MDM2 signaling pathway. Our results suggest that supplementation with estrogen and/or overexpression of estrogen receptor β gene may prove to be effective means to treat stress-induced myocardial damage.
Brain-Derived Neurotrophic Factor Mediated Perfluorooctane Sulfonate Induced-Neurotoxicity via Epigenetics Regulation in SK-N-SH Cells
Authors: Guo Xin-Xin , He Qing-Zhi , Li Wu , Long Ding-Xin , Pan Xiao-Yuan , Chen Cong , Zeng Huai-Cai
Published: April 2017

Perfluorooctane sulfonate (PFOS), a new kind of persistent organic pollutant, is widely distributed in the environment and exists in various organisms, where it is also a neurotoxic compound. However, the potential mechanism of its neurotoxicity is still unclear. To examine the role of epigenetics in the neurotoxicity induced by PFOS, SK-N-SH cells were treated with different concentrations of PFOS or control medium (0.1% DMSO) for 48 h. The mRNA levels of DNA methyltransferases (DNMTs) and Brain-derived neurotrophic factor (BDNF), microRNA-16, microRNA-22, and microRNA-30a-5p were detected by Quantitative PCR (QPCR). Enzyme Linked Immunosorbent Assay (ELISA) was used to measure the protein levels of BDNF, and a western blot was applied to analyze the protein levels of DNMTs. Bisulfite sequencing PCR (BSP) was used to detect the methylation status of the BDNF promoter I and IV. Results of MTT assays indicated that treatment with PFOS could lead to a significant decrease of cell viability, and the treated cells became shrunk. In addition, PFOS exposure decreased the expression of BDNF at mRNA and protein levels, increased the expression of microRNA-16, microRNA-22, microRNA-30a-5p, and decreased the expression of DNMT1 at mRNA and protein levels, but increased the expression of DNMT3b at mRNA and protein levels. Our results also demonstrate that PFOS exposure changes the methylation status of BDNF promoter I and IV. The findings of the present study suggest that methylation regulation of BDNF gene promoter and increases of BDNF-related-microRNA might underlie the mechanisms of PFOS-induced neurotoxicity.
Acteoside and Isoacteoside Protect Amyloid β Peptide Induced Cytotoxicity, Cognitive Deficit and Neurochemical Disturbances In Vitro and In Vivo
Authors: Shiao Young-Ji , Su Muh-Hwan , Lin Hang-Ching , Wu Chi-Rei
Published: April 2017

Acteoside and isoacteoside, two phenylethanoid glycosides, coexist in some plants. This study investigates the memory-improving and cytoprotective effects of acteoside and isoacteoside in amyloid β peptide 1-42 (Aβ 1-42)-infused rats and Aβ 1-42-treated SH-SY5Y cells. It further elucidates the role of amyloid cascade and central neuronal function in these effects. Acteoside and isoacteoside ameliorated cognitive deficits, decreased amyloid deposition, and reversed central cholinergic dysfunction that were caused by Aβ 1-42 in rats. Acteoside and isoacteoside further decreased extracellular Aβ 1-40 production and restored the cell viability that was decreased by Aβ 1-42 in SH-SY5Y cells. Acteoside and isoacteoside also promoted Aβ 1-40 degradation and inhibited Aβ 1-42 oligomerization in vitro. However, the memory-improving and cytoprotective effects of isoacteoside exceeded those of acteoside. Isoacteoside promoted exploratory behavior and restored cortical and hippocampal dopamine levels, but acteoside did not. We suggest that acteoside and isoacteoside ameliorated the cognitive dysfunction that was caused by Aβ 1-42 by blocking amyloid deposition via preventing amyloid oligomerization, and reversing central neuronal function via counteracting amyloid cytotoxicity.
Historical Analysis of Riparian Vegetation Change in Response to Shifting Management Objectives on the Middle Rio Grande
Authors: Petrakis Roy , Van Leeuwen Willem , Villarreal Miguel L. , Tashjian Paul , Dello Russo Regina , Scott Christopher
Published: April 2017

Riparian ecosystems are valuable to the ecological and human communities that depend on them. Over the past century, they have been subject to shifting management practices to maximize human use and ecosystem services, creating a complex relationship between water policy, management, and the natural ecosystem. This has necessitated research on the spatial and temporal dynamics of riparian vegetation change. The San Acacia Reach of the Middle Rio Grande has experienced multiple management and river flow fluctuations, resulting in threats to its riparian and aquatic ecosystems. This research uses remote sensing data, GIS, a review of management decisions, and an assessment of climate to both quantify how riparian vegetation has been altered over time and provide interpretations of the relationships between riparian change and shifting climate and management objectives. This research focused on four management phases from 1935 to 2014, each highlighting different management practices and climate-driven river patterns, providing unique opportunities to observe a direct relationship between river management, climate, and riparian response. Overall, we believe that management practices coupled with reduced surface river-flows with limited overbank flooding influenced the compositional and spatial patterns of vegetation, including possibly increasing non-native vegetation coverage. However, recent restoration efforts have begun to reduce non-native vegetation coverage.
Osteoblast Cell Response on the Ti6Al4V Alloy Heat-Treated
Authors: Chávez-Díaz Mercedes , Escudero-Rincón María , Arce-Estrada Elsa , Cabrera-Sierra Román
Published: April 2017

In an effort to examine the effect of the microstructural changes of the Ti6Al4V alloy, two heat treatments were carried out below (Ti6Al4V800) and above (Ti6Al4V1050) its β-phase transformation temperature. After each treatment, globular and lamellar microstructures were obtained. Saos-2 pre-osteoblast human osteosarcoma cells were seeded onto Ti6Al4V alloy disks and immersed in cell culture for 7 days. Electrochemical assays in situ were performed using OCP and EIS measurements. Impedance data show a passive behavior for the three Ti6Al4V alloys; additionally, enhanced impedance values were recorded for Ti6Al4V800 and Ti6Al4V1050 alloys. This passive behavior in culture medium is mostly due to the formation of TiO2 during their sterilization. Biocompatibility and cell adhesion were characterized using the SEM technique; Ti6Al4V as received and Ti6Al4V800 alloys exhibited polygonal and elongated morphology, whereas Ti6Al4V1050 alloy displayed a spherical morphology. Ti and O elements were identified by EDX analysis due to the TiO2 and signals of C, N and O, related to the formation of organic compounds from extracellular matrix. These results suggest that cell adhesion is more likely to occur on TiO2 formed in discrete α-phase regions (hcp) depending on its microstructure (grains).
Axially Ligated Phthalocyanine Conductors with Magnetic Moments
Authors: Inabe Tamotsu , Hanasaki Noriaki
Published: April 2017

This mini-review describes electrical conductivity, magnetic properties, and magnetotransport properties of one-dimensional partially oxidized salts composed of axially ligated phthalocyanines, TPP[M(Pc)(CN)2]2 (TPP = tetraphenylphosphonium, Pc = phthalocyaninato), with M of Fe (d5, S = 1/2) and Cr (d3, S = 3/2). These salts are isomorphous, and π–π interactions in the crystal, that becomes the origin of the charge carriers, are nearly the same. Both the Fe and Cr salts show carrier localization and charge disproportionation which is enhanced by the interaction between local magnetic moments and conduction π-electrons (π–d interaction). However, the magnetic properties are slightly different between them. M = Fe has been found to show unique anisotropic magnetic properties and antiferromagnetic short-range magnetic order between the d-spins. On the other hand, for M = Cr, its magnetic moment is isotropic. Temperature dependence of the magnetic susceptibility shows typical Curie–Weiss behavior with negative Weiss temperature, but the exchange interaction is complicated. Both M = Fe and M = Cr show large negative magnetoresistance, reflecting the difference in the anisotropy. The magnetoresistance ratio (MR) is larger in the Fe system than in the Cr system in the low magnetic field range, but MR in the Cr system exceeds that in the Fe system when the magnetic field becomes higher than 15 T. We discuss the mechanism of the giant negative magnetoresistance with reference to the d–d, π–d, and π–π interactions.
Peptides, Peptidomimetics, and Polypeptides from Marine Sources: A Wealth of Natural Sources for Pharmaceutical Applications
Authors: Sable Rushikesh , Parajuli Pravin , Jois Seetharama
Published: April 2017

Nature provides a variety of peptides that are expressed in most living species. Evolutionary pressure and natural selection have created and optimized these peptides to bind to receptors with high affinity. Hence, natural resources provide an abundant chemical space to be explored in peptide-based drug discovery. Marine peptides can be extracted by simple solvent extraction techniques. The advancement of analytical techniques has made it possible to obtain pure peptides from natural resources. Extracted peptides have been evaluated as possible therapeutic agents for a wide range of diseases, including antibacterial, antifungal, antidiabetic and anticancer activity as well as cardiovascular and neurotoxin activity. Although marine resources provide thousands of possible peptides, only a few peptides derived from marine sources have reached the pharmaceutical market. This review focuses on some of the peptides derived from marine sources in the past ten years and gives a brief review of those that are currently in clinical trials or on the market.
Qigong Exercise May Reduce Serum TNF-α Levels and Improve Sleep in People with Parkinson’s Disease: A Pilot Study
Authors: Moon Sanghee , Schmidt Marshall , Smirnova Irina , Colgrove Yvonne , Liu Wen
Published: April 2017

Background: Inflammatory cytokine levels are often elevated in people with Parkinson’s disease (PD). People with PD often experience sleep disturbances that significantly impact quality of life. Past studies suggest inflammatory cytokines may be associated with various symptoms of PD. Benefits of Qigong, a mind–body exercise, have been shown in different neurological conditions, but there is still a lack of clinical evidence in the PD population. Methods: Ten people with PD were recruited and randomly assigned into two groups receiving six weeks of Qigong (experimental group) or sham Qigong (control group) intervention. The levels of TNF-α, IL-1β, and IL-6 in subjects’ serum and sleep quality were measured before and after the intervention. Results: After the intervention, the serum level of TNF-α in the experimental group was significantly decreased in all subjects, while the level in the control group showed a trend to increase. Qigong exercise significantly improved sleep quality at night. There was a strong correlation between changes in the level of TNF-α and sleep quality. Conclusion: Qigong exercise decreased TNF-α level in people with PD and helped improve sleep quality. TNF-α may have a potential to influence the sleep quality in people with PD.
Microstructure and Mechanical Properties of J55ERW Steel Pipe Processed by On-Line Spray Water Cooling
Authors: Chen Zejun , Chen Xin , Zhou Tianpeng
Published: April 2017

An on-line spray water cooling (OSWC) process for manufacturing electric resistance welded (ERW) steel pipes is presented to enhance their mechanical properties and performances. This technique reduces the processing needed for the ERW pipe and overcomes the weakness of the conventional manufacturing technique. Industrial tests for J55 ERW steel pipe were carried out to validate the effectiveness of the OSWC process. The microstructure and mechanical properties of the J55 ERW steel pipe processed by the OSWC technology were investigated. The optimized OSWC technical parameters are presented based on the mechanical properties and impact the performance of steel pipes. The industrial tests show that the OSWC process can be used to efficiently control the microstructure, enhance mechanical properties, and improve production flexibility of steel pipes. The comprehensive mechanical properties of steel pipes processed by the OSWC are superior to those of other published J55 grade steels.
Characteristics of Strata Behavior during Thick Seam Mining by Fully-Mechanized Top Coal Caving in a Loess-Covered Gullied Region
Authors: Wang Xu-feng , Wang Yang , Zhang Dong-sheng , Wang Hong-zhi , Zhang Yang , Qin Dongdong , Zhang Chengguo
Published: April 2017

This study systematically investigates the overburden movement and strata behavior at a fully-mechanized top coal caving (FMTCC) face in a thick coal seam in a loess-covered gullied region by field measurement and theoretical analysis. A comparative analysis was performed to examine how the attitude of surface gullies and the structure of overburden affect face support resistance. The characteristics and evolution mechanism of strata behavior during FMTCC under gully slopes in a loess-covered gullied region were discovered through a mechanical analysis of the roof structure and a comparison to the mining of a typical shallow seam under gully slopes. The study found that as the FMTCC face advanced, the strata behavior initiated in the middle part of the face and then continued to both ends, and its intensity was higher in the middle part than in the upper and lower parts. During mining under gullies, the increases in support resistance were generally less than 5% (except for the maximum increases of 7–9%), indicating that the occurrence of gullies on the surface had little influence on the strata behavior at the FMTCC face. Due to the increased burial depth and the number of key strata, the roof at the FMTCC face under gullies formed a stable load-bearing structure called a voussoir beam, which was the key difference from the strata behavior characteristics in the shallow mine under gullies.
Schwertmannite Adherence to the Reactor Wall during the Bio-Synthesis Process and Deterioration of Its Structural Characteristics and Arsenic(III) Removal Efficiency
Authors: Zhang Jian , Shi Jing , Zhang Shasha , Zhou Lixiang , Xu Jianmin , Ge Yuanying , Fan Wenhua , Liu Fenwu
Published: April 2017

Schwertmannite, a kind of iron oxyhydrosulfate mineral, can removal arsenic(III) from arsenic(III)-bearing groundwater by the adsorption process. In this study, schwertmannite was bio-synthesized by Acidithiobacillus ferrooxidans LX5 in shaking flasks (160 rpm) containing a 0.16 mol/L FeSO4 liquid solution. After bio-synthesis, 25.5% of the bio-synthesized schwertmannite adhered to the reactor wall (designated as adhered-sch) and the remainder was suspended in the system (designated as suspended-sch). Particles of adhered-sch exhibited a fractured structure with a small specific surface area (4.36 m2/g) and total pore volume (3.13 × 10−2 cm3/g). In contrast, suspended-sch had a spiny structure (similar in appearance to a hedgehog), and a larger specific surface area (9.62 m2/g) and total pore volume (8.01 × 10−2 cm3/g). When 0.25 g/L of adhered-sch was used as an adsorbent for arsenic(III) removal from 1 mg/L arsenic(III)-bearing waters (at pH 7.5), the arsenic(III) removal efficiency was 43.2% after 4 h of adsorption. However, this efficiency could be increased by 50% by using suspended-sch as the adsorbent. Furthermore, by adding 13.3 g/L and 26.7 g/L additional schwertmannite into the reactor system prior to schwertmannite bio-synthesis, all synthesized schwertmannite remained suspended in the bio-synthesis systems, and the ferrous ions’ bio-oxidation efficiency was improved to a certain extent. Due to the friction effect between the introduced schwertmannite and the reactor wall, adhered-sch was eliminated. The outcomes of this study will provide the necessary data for schwertmannite bio-synthesis and arsenic(III) removal from arsenic(III)-bearing groundwater.
Modified Nucleotides as Substrates of Terminal Deoxynucleotidyl Transferase
Authors: Tauraitė Daiva , Jakubovska Jevgenija , Dabužinskaitė Julija , Bratchikov Maksim , Meškys Rolandas
Published: April 2017

The synthesis of novel modified nucleotides and their incorporation into DNA sequences opens many possibilities to change the chemical properties of oligonucleotides (ONs), and, therefore, broaden the field of practical applications of modified DNA. The chemical synthesis of nucleotide derivatives, including ones bearing thio-, hydrazino-, cyano- and carboxy groups as well as 2-pyridone nucleobase-containing nucleotides was carried out. The prepared compounds were tested as substrates of terminal deoxynucleotidyl transferase (TdT). The nucleotides containing N4-aminocytosine, 4-thiouracil as well as 2-pyridone, 4-chloro- and 4-bromo-2-pyridone as a nucleobase were accepted by TdT, thus allowing enzymatic synthesis of 3’-terminally modified ONs. The successful UV-induced cross-linking of 4-thiouracil-containing ONs to TdT was carried out. Enzymatic post-synthetic 3’-modification of ONs with various photo- and chemically-reactive groups opens novel possibilities for future applications, especially in analysis of the mechanisms of polymerases and the development of photo-labels, sensors, and self-assembling structures.