bluuebunny/crossref_metadata_2025 huggingface dataset:
Effective Prediction of Concrete Constitutive Models for Reinforced Concrete Shear Walls under Cyclic Loading
Authors: To Quoc Bao , Shin Jiuk , Kim Sung Jig , Kim Hye-Won , Lee Kihak
Published: April 2024

One of the most challenging elements of modeling the behaviour of reinforced concrete (RC) walls is combining realistic material models that can capture the observable behaviour of the physical system. Experiments with realistic loading rates and pressures reveal that steel and concrete display complicated nonlinear behaviour that is challenging to represent in a single constitutive model. To investigate the response of a reinforced concrete structure subjected to dynamic loads, this paper’s study is based on many different material models to assess the advantages and disadvantages of the models on 2D and 3D RC walls using the LS-DYNA program. The models consisted of the KCC model and the CDP model, which represented plasticity and distinct tensile/compressive damage models, and the Winfrith model, which represented plasticity and the smeared crack model. Subsequently, the models’ performances were assessed by comparing them to experimental data from reinforced concrete structures, in order to validate the accuracy of the overall behaviour prediction. The Winfrith model demonstrated satisfactory results in predicting the behaviour of 2D and 3D walls, including maximum strength, stiffness deterioration, and energy dissipation. The method accurately predicted the maximum strength of the Winfrith concrete model for the 2D wall with an error of 9.24% and for the 3D wall with errors of 3.28% in the X direction and 5.02% in the Y direction. The Winfrith model demonstrated higher precision in predicting dissipation energy for the 3D wall in both the X and Y directions, with errors of 6.84% and 6.62%, correspondingly. Additional parametric analyses were carried out to investigate structural behaviour, taking into account variables such as concrete strength, strain rate, mesh size, and the influence of the element type.
A Review of Dynamic Mechanical Behavior and the Constitutive Models of Aluminum Matrix Composites
Authors: Li Siyun , Luo Tian , Chao Zhenlong , Jiang Longtao , Han Huimin , Han Bingzhuo , Du Shanqi , Liu Mingqi
Published: April 2024

Aluminum matrix composites (AMMCs) have demonstrated substantial potential in the realm of armor protection due to their favorable properties, including low density, high specific stiffness, and high specific strength. These composites are widely employed as structural components and frequently encounter high strain rate loading conditions, including explosions and penetrations during service. And it is crucial to note that under dynamic conditions, these composites exhibit distinct mechanical properties and failure mechanisms compared to static conditions. Therefore, a thorough investigation into the dynamic mechanical behavior of aluminum matrix composites and precise constitutive equations are imperative to advance their application in armor protection. This review aims to explore the mechanical properties, strengthening the mechanism and deformation damage mechanism of AMMCs under high strain rate. To facilitate a comprehensive understanding, various constitutive equations are explored, including phenomenological constitutive equations, those with physical significance, and those based on artificial neural networks. This article provides a critical review of the reported work in this field, aiming to analyze the main challenges and future development directions of aluminum matrix composites in the field of protection.
Dilatational and Shear Interfacial Properties of Pea Protein Isolate Systems with Transglutaminase at the Air–Water Interface
Authors: Baldino Noemi , Mileti Olga , Paleologo Mario F. O. , Lupi Francesca R. , Gabriele Domenico
Published: April 2024

In recent years, the demand for foods without animal proteins has increased, both for health and ethical reasons. Replacing animal protein in foods can result in unappealing textures, hindering consumer acceptance. In this context, interfacial properties also play a crucial role in food systems like foam or emulsions. Therefore, the interfacial rheological behavior at the air–water interface of pea protein isolate (PPI) has been investigated to understand how affects food foam production. The PPI has been studied without modification and also through enzymatic treatment with transglutaminase (TG) to understand the interfacial properties of the modified proteins. Data obtained by static measurements have shown a surface activity of PPI comparable with other vegetable proteins, while the treatment with TG does not significantly alter the surface tension value and the interfacial adsorption rate. Differences have been found in the rearrangement rate, which decreases with TG, suggesting a possible crosslinking of the pea proteins. The PPI modified with TG, studied in dynamic conditions both in dilation and shear kinematics, are less elastic than PPI that is untreated but with a higher consistency, which may lead to poor foam stability. The lower complex interfacial modulus obtained under shear conditions also suggests a low long-time stability.
Discovery of a Novel Chromone Enantiomer and the Precursors of Nonactic Acid from the Coral-Reef-Derived Streptomyces sp. SCSIO 66814
Authors: Ding Wenping , Li Yanqun , Li Xingyu , Yin Jiajia , Shi Songbiao , Tian Xinpeng , Zhang Si , Yin Hao
Published: April 2024

Three pairs of enantiomers (1–3)—the new 12R-aloesol (1a) and two new fatty acids (2 and 3)—and one new natural product (4) together three known compounds (5–7) were isolated from a coral-reef-derived Streptomyces sp. SCSIO 66814. Their structures were determined through extensive spectroscopic analysis, chiral analysis, and single-crystal X-ray diffraction data. Compounds 2 and 3 were presumed to be intermediates for further generating homononactic acid (5) and nonactic acid, and the latter two molecules were able to act as precursors to form macrotetrolides with remarkable biological activity. The isolation of related precursors, compounds 2–5, provided more evidence to support the proposal of a plausible biosynthetic pathway for nonactic acid and its homologs. Additionally, (+)-1 exhibited a weak activity against DPPH radicals.
Use of Reverse Shock Index Multiplied by Simplified Motor Score in a Five-Level Triage System: Identifying Trauma in Adult Patients at a High Risk of Mortality
Authors: Lin Po-Chen , Wu Meng-Yu , Chien Da-Sen , Chung Jui-Yuan , Liu Chi-Yuan , Tzeng I-Shiang , Hou Yueh-Tseng , Chen Yu-Long , Yiang Giou-Teng
Published: April 2024

Background and Objectives: The Taiwan Triage and Acuity Scale (TTAS) is reliable for triaging patients in emergency departments in Taiwan; however, most triage decisions are still based on chief complaints. The reverse-shock index (SI) multiplied by the simplified motor score (rSI-sMS) is a more comprehensive approach to triage that combines the SI and a modified consciousness assessment. We investigated the combination of the TTAS and rSI-sMS for triage compared with either parameter alone as well as the SI and modified SI. Materials and Methods: We analyzed 13,144 patients with trauma from the Taipei Tzu Chi Trauma Database. We investigated the prioritization performance of the TTAS, rSI-sMS, and their combination. A subgroup analysis was performed to evaluate the trends in all clinical outcomes for different rSI-sMS values. The sensitivity and specificity of rSI-sMS were investigated at a cutoff value of 4 (based on previous study and the highest score of the Youden Index) in predicting injury severity clinical outcomes under the TTAS system were also investigated. Results: Compared with patients in triage level III, those in triage levels I and II had higher odds ratios for major injury (as indicated by revised trauma score < 7 and injury severity score [ISS] ≥ 16), intensive care unit (ICU) admission, prolonged ICU stay (≥14 days), prolonged hospital stay (≥30 days), and mortality. In all three triage levels, the rSI-sMS < 4 group had severe injury and worse outcomes than the rSI-sMS ≥ 4 group. The TTAS and rSI-sMS had higher area under the receiver operating characteristic curves (AUROCs) for mortality, ICU admission, prolonged ICU stay, and prolonged hospital stay than the SI and modified SI. The combination of the TTAS and rSI-sMS had the highest AUROC for all clinical outcomes. The prediction performance of rSI-sMS < 4 for major injury (ISS ≥ 16) exhibited 81.49% specificity in triage levels I and II and 87.6% specificity in triage level III. The specificity for mortality was 79.2% in triage levels I and II and 87.4% in triage level III. Conclusions: The combination of rSI-sMS and the TTAS yielded superior prioritization performance to TTAS alone. The integration of rSI-sMS and TTAS effectively enhances the efficiency and accuracy of identifying trauma patients at a high risk of mortality.
The Effect of Pringle Maneuver Applied during Living Donor Hepatectomy on the Ischemia-Reperfusion Injury Observed in the Donors and Recipients
Authors: Dalda Yasin , Akbulut Sami , Sahin Tevfik Tolga , Tuncer Adem , Ogut Zeki , Satilmis Basri , Dalda Ozlem , Gul Mehmet , Yilmaz Sezai
Published: April 2024

Background and Objectives: The aim of this study is to evaluate the clinical and laboratory changes of ischemia and reperfusion injury in the remnant livers of donors with and without Pringle maneuver. Furthermore, we evaluated the recipients who have been transplanted with liver grafts from these donors. Methods and Materials: A total of 108 patients (54 living liver donors and 54 liver recipients) who underwent donor hepatectomy and recipients who living donor liver transplantation, were included in this randomized double-blind study between February 2021 and June 2021. The donors were divided into two groups: Pringle maneuver applied (n = 27) and Pringle maneuver not applied (n = 27). Similarly, recipients with implanted liver obtained from these donors were divided into two groups as the Pringle maneuver was performed (n = 27) and not performed (n = 27). Blood samples from donors and recipients were obtained on pre-operative, post-operative 0 h day (day of surgery), post-operative 1st day, post-operative 2nd day, post-operative 3rd day, post-operative 4th day, post-operative 5th day, and liver tissue was taken from the graft during the back table procedures. Liver function tests and complete blood count, coagulation tests, IL-1, IL-2, IL-6, TNF-α, and β-galactosidase measurements, and histopathological findings were examined. Results: There was no statistically significant difference in the parameters of biochemical analyses for ischemia-reperfusion injury at all periods in the donors with and without the Pringle maneuver. Similarly, there was no statistically significant difference between in the recipients in who received liver grafts harvested with and without the Pringle maneuver. There was no statistically significant difference between the two recipient groups in terms of perioperative bleeding and early bile duct complications (p = 0.685). In the histopathological examinations, hepatocyte damage was significantly higher in the Pringle maneuver group (p = 0.001). Conclusions: Although the histological scoring of hepatocyte damage was found to be higher in the Pringle maneuver group, the Pringle maneuver did not augment ischemia-reperfusion injury in donors and recipients that was evaluated by clinical and laboratory analyses.
Unveiling Metal Tolerance Mechanisms in Leersia hexandra Swartz under Cr/Ni Co-Pollution by Studying Endophytes and Plant Metabolites
Authors: Chen Mouyixing , Yu Guo , Qiu Hui , Jiang Pingping , Zhong Xuemei , Liu Jie
Published: April 2024

Heavy metal pollution poses significant environmental challenges, and understanding how plants and endophytic bacteria interact to mitigate these challenges is of utmost importance. In this study, we investigated the roles of endophytic bacteria, particularly Chryseobacterium and Comamonas, in Leersia hexandra Swartz (L. hexandra) in response to chromium and nickel co-pollution. Our results demonstrated the remarkable tolerance of Chryseobacterium and Comamonas to heavy metals, and their potential to become dominant species in the presence of co-pollution. We observed a close relationship between these endophytic bacteria and the significant differences in metabolites, particularly carbohydrates, flavonoids, and amino acids in L. hexandra. These findings shed light on the potential of endophytic bacteria to promote the production of aspartic acid and other metabolites in plants as a response to abiotic stressors. Furthermore, our study presents a new direction for plant and bioremediation strategies in heavy metal pollution and enhances our understanding of L. hexandra’s mechanisms for heavy metal tolerance.
Resistance Feedback of a Ni-Ti Alloy Actuator at Room Temperature in Still Air
Authors: Durante Francesco , Raparelli Terenziano , Beomonte Zobel Pierluigi
Published: April 2024

This paper illustrates an experimental activity for the closed-loop position control of an actuator made using shape memory alloy (SMA) wire. A solution with the self-sensing effect was implemented to miniaturize the systems, i.e., without external sensors. A proportional control algorithm was initially used, demonstrating the idea’s feasibility; the wire can behave simultaneously as an actuator and sensor. An experimental investigation was subsequently conducted for the optimization of the developed actuator. As for the material, a Flexinol wire, Ni-Ti alloy, with a diameter of 0.150 mm and a length of 200 mm, was used. Preliminarily, characterization of the SMA wire at constant and variable loads was carried out; the characteristics detected were elongation vs. electric current and elongation vs. electrical resistance. The control system is PC based with a data acquisition card (DAQ). A drive board was designed and built to read the wire’s electrical resistance and power it by pulse width modulation (PWM). A notable result is that the actuator works with good precision and in dynamic conditions, even when it is called to support a load up to 65% different from that for which the electrical resistance–length correlation has previously been experimentally obtained, on which the control is based. This opens up the possibility of using the actuator in a counteracting configuration with a spring, which makes hardware implementation and control management simple.
Porous Inorganic Nanomaterials: Their Evolution towards Hierarchical Porous Nanostructures
Authors: Jose Anitta , Mathew Tom , Fernández-Navas Nora , Querebillo Christine Joy
Published: April 2024

The advancement of both porous materials and nanomaterials has brought about porous nanomaterials. These new materials present advantages both due to their porosity and nano-size: small size apt for micro/nano device integration or in vivo transport, large surface area for guest/target molecule adsorption and interaction, porous channels providing accessibility to active/surface sites, and exposed reactive surface/active sites induced by uncoordinated bonds. These properties prove useful for the development of different porous composition types (metal oxides, silica, zeolites, amorphous oxides, nanoarrays, precious metals, non-precious metals, MOFs, carbon nanostructures, MXenes, and others) through different synthetic procedures—templating, colloidal synthesis, hydrothermal approach, sol-gel route, self-assembly, dealloying, galvanostatic replacement, and so—for different applications, such as catalysis (water-splitting, etc.), biosensing, energy storage (batteries, supercapacitors), actuators, SERS, and bio applications. Here, these are presented according to different material types showing the evolution of the structure design and development towards the formation of hierarchical porous structures, emphasizing that the formation of porous nanostructures came about out of the desire and need to form hierarchical porous nanostructures. Common trends observed across these different composition types include similar (aforementioned) applications and the use of porous nanomaterials as templates/precursors to create novel ones. Towards the end, a discussion on the link between technological advancements and the development of porous nanomaterials paves the way to present future perspectives on these nanomaterials and their hierarchical porous architectures. Together with a summary, these are given in the conclusion.
Non-O1/Non-O139 Vibrio cholerae—An Underestimated Foodborne Pathogen? An Overview of Its Virulence Genes and Regulatory Systems Involved in Pathogenesis
Authors: Zhang Quantao , Alter Thomas , Fleischmann Susanne
Published: April 2024

In recent years, the number of foodborne infections with non-O1 and non-O139 Vibrio cholerae (NOVC) has increased worldwide. These have ranged from sporadic infection cases to localized outbreaks. The majority of case reports describe self-limiting gastroenteritis. However, severe gastroenteritis and even cholera-like symptoms have also been described. All reported diarrheal cases can be traced back to the consumption of contaminated seafood. As climate change alters the habitats and distribution patterns of aquatic bacteria, there is a possibility that the number of infections and outbreaks caused by Vibrio spp. will further increase, especially in countries where raw or undercooked seafood is consumed or clean drinking water is lacking. Against this background, this review article focuses on a possible infection pathway and how NOVC can survive in the human host after oral ingestion, colonize intestinal epithelial cells, express virulence factors causing diarrhea, and is excreted by the human host to return to the environment.
Characterization of a Nickel Sulfide Concentrate and Its Implications on Pentlandite Beneficiation
Authors: Ayedzi Linda D. , Zanin Massimiliano , Skinner William , Abaka-Wood George B.
Published: April 2024

In anticipation of future demands, a comprehensive understanding of the chemical and mineralogical characteristics of nickel-bearing minerals is a prerequisite to devising effective nickel beneficiation methods. Of particular importance are markers in the mineralogy of the flotation concentrate that inform beneficiation strategies to improve concentrate grades, increasing both the marketability and cost of refining. In this work, a detailed characterization of a complex nickel sulfide flotation concentrate from a Western Australian deposit was carried out to determine the mode of occurrence and distribution of nickel and the associated gangue minerals, with the view of identifying prudent beneficiation strategies to improve concentrate grades. The concentrate was characterized via particle, chemical, and mineralogical techniques. Particle size analysis of the concentrate showed that it consisted predominantly of fine and ultra-fine particles (<20 μm), with the nickel value concentrated in the finer size fractions. Nickel mineralization in the ore (by quantitative X-ray diffraction) was found to be within pentlandite, violarite, millerite, and gersdorffite. The sulfide gangue was predominantly pyrrhotite, pyrite, chalcopyrite, sphalerite, arsenopyrite, and galena. Quantitative evaluation of minerals by scanning microscopy (QEMSCAN) analysis revealed that nickel minerals are at least 91% liberated, and the remaining portion (around 7%) is locked within binary iron (Fe) sulfides and 2% within complex minerals. Based on these findings, potential processing options, such as magnetic separation, gravity separation, and froth flotation, for recovering and upgrading nickel from this concentrate are discussed. Notably, with the significant presence of ultrafine/fine pyrrhotite content, averaging around 52% in the minus 38 µm fraction, novel flotation cells, including the Jameson cell, column flotation cells, and Reflux flotation cell (RFC), have been identified as potential candidates for fine/ultrafine pentlandite recovery. Overall, the characterization study conducted suggests that acquiring knowledge about the mineralogical characteristics of existing mineral concentrates can serve as a pathway to improving future concentrate grades.
Accelerated Carbonation of High-Calcite Wollastonite Tailings
Authors: Ismailov Arnold , Merilaita Niina , Levänen Erkki
Published: April 2024

Wollastonite (CaSiO3) is the most researched and well-defined mineral in the field of CO2 mineralization, but it is also a sought-after process mineral and thus, not easily justified for large scale ex situ carbon sequestration, which requires an energy-intensive step of comminution to increase reactivity. Wollastonite-rich mine tailings are a side stream with an already fine particle size resulting from the extractive process, but their effective utilization is problematic due to legislation, logistics, a high number of impurities, and chemical inconsistency. In this study, the accelerated weathering (aqueous carbonation) of high-calcite (CaCO3) wollastonite tailings was studied under elevated temperatures and high partial pressures of CO2 to determine the carbon sequestration potential of those tailings compared to those of pure reference wollastonite originating from the same quarry. The main process variables were pressure (20–100 bar), temperature (40 °C–60 °C), and time (10 min–24 h). Despite consisting largely of non-reactive silicates and primary calcite, very fine tailings showed promise in closed-chamber batch-type aqueous carbonation, achieving a conversion extent of over 28% in one hour at 100 bar and 60 °C.
Study on the Performance of Recycled Cement-Stabilized Macadam Mixture Improved Using Alkali-Activated Lithium Slag–Fly Ash Composite
Authors: Yang Weijun , Jin Zhenzhou , Yang Jianyu , He Jiangang , Huang Xuemei , Ye Xin , Li Guangyao , Wang Chao
Published: April 2024

The huge demand for sand and gravel resources in road engineering construction leads to excessive consumption of resources and environmental damage. Recycling waste concrete and industrial solid waste as a road material is a promising alternative. In order to explore the application of these solid wastes in the road base, this paper studies the effect of adding lithium slag activated by an alkaline activator, fly ash (FA) and a combination of the two on the compressive strength, splitting strength and shrinkage performance of recycled cement-stabilized macadam mixture (RCSM). The optimum content of recycled aggregate (RA), alkali-activated lithium slag (AALS) and FA in composite-improved RCSM was optimized using a response surface method (Box–Behnken), and the microscopic characteristics of the mixture were analyzed using X-ray diffraction (XRD) and scanning electron microscopy (SEM). The results show that the optimum dosage of AALS, FA and RA determined by the response surface method is 15%, 10% and 40%, respectively. Compared with the cement-stabilized macadam mixture (CSM) with 40% RA, the 28 d compressive strength and 28 d splitting strength of the composite-improved RCSM are increased by 26.8% and 22.9%, respectively, and the dry shrinkage coefficient and average temperature shrinkage coefficient are decreased by 25.8% and 14.8%, respectively. Microscopic tests show that AALS and FA participate in the hydration reaction, generate more hydrated silicate (C-S-H) and ettringite (AFt), refine pores, effectively improve the performance of the internal interface transition zone of the mixture, make the microstructure of the mixture denser, and improve the strength and shrinkage performance of RCSM. This study provides technical support for the reuse of resources and the sustainable development of road construction.
26SCS-Loaded SilMA/Col Composite Sponge with Well-Arranged Layers Promotes Angiogenesis-Based Diabetic Wound Repair by Mediating Macrophage Inflammatory Response
Authors: Luo Pin , Liu Wei , Ye Zhangyao , Zhang Yuyu , Zhang Zekun , Yi Jing , Zeng Rong , Yang Shenyu , Tu Mei
Published: April 2024

Diabetic wound healing is a significant clinical challenge because abnormal immune cells in the wound cause chronic inflammation and impair tissue regeneration. Therefore, regulating the behavior and function of macrophages may be conducive to improving treatment outcomes in diabetic wounds. Herein, sulfated chitosan (26SCS)-containing composite sponges (26SCS-SilMA/Col-330) with well-arranged layers and high porosity were constructed based on collagen and silk fibroin, aiming to induce an appropriate inflammatory response and promote angiogenesis. The results indicated that the ordered topological structure of composite sponges could trigger the pro-inflammatory response of Mφs in the early stage, and rapid release of 26SCS in the early and middle stages (within the concentration range of 1–3 mg/mL) induced a positive inflammatory response; initiated the pro-inflammatory reaction of Mφs within 3 days; shifted M1 Mφs to the M2 phenotype within 3–7 days; and significantly up-regulated the expression of two typical angiogenic growth factors, namely VEGF and PDGF-BB, on day 7, leading to rapid HUVEC migration and angiogenesis. In vivo data also demonstrated that on the 14th day after surgery, the 26SCS-SilMA/Col-330-implanted areas exhibited less inflammation, faster re-epithelialization, more abundant collagen deposition and a greater number of blood vessels in the skin tissue. The composite sponges with higher 26SCS contents (the (5.0) 26SCS-SilMA/Col-330 and the (7.5) 26SCS-SilMA/Col-330) could better orchestrate the phenotype and function of Mφs and facilitate wound healing. These findings highlight that the 26SCS-SilMA/Col-330 sponges developed in this work might have great potential as a novel dressing for the treatment of diabetic wounds.
ZIF-67-Derived Flexible Sulfur Cathode with Improved Redox Kinetics for High-Performance Li-S Batteries
Authors: Cheng Chen , Wu Hanyan , Chen Xinyang , Cai Shuiping , Tian Yingkang , Yang Xiaofei , Gao Xuejie
Published: April 2024

Lithium–sulfur (Li-S) batteries have received much attention due to their high energy density and low price. In recent years, alleviating the volume expansion and suppressing the shuttle effect during the charge and discharge processes of Li-S batteries have been widely addressed. However, the slow conversion kinetics from polysulfide (LiPSs) to Li2S2/Li2S still limits the application of Li-S batteries. Therefore, we designed a ZIF-67 grown on cellulose (named ZIF-67@CL) as an electrocatalyst to improve the interconversion kinetics from LiPSs to Li2S2/Li2S for Li-S batteries. Based on the results of adsorption experiments of LiPSs, ZIF-67@CL and CL hosts were immersed in Li2S4 solution to adsorb LiPSs, and the UV-Vis test was conducted on the supernatant after adsorption. The results showed that the ZIF-67@CL had a stronger adsorption for LiPSs compared with the cellulose (CL). Furthermore, in the Li2S nucleation tests, the fabricated cells were galvanostatically discharged to 2.06 V at 0.112 mA and then potentiostatically discharged at 2.05 V. Based on the results of Li2S nucleation tests, the catalytic effect of ZIF-67 was further verified. As a result, the sulfur cathode used a ZIF-67 catalyst (named S/ZIF-67@CL) and delivered an initial capacity of 1346 mAh g−1 at a current density of 0.2 C. Even at a high current density of 2 C, it exhibited a high-capacity performance of 1087 mAh g−1 on the first cycle and maintained a capacity output of 462 mAh g−1 after 150 cycles, with a Coulombic efficiency of over 99.82%.
Emulsion Liquid Membranes Based on Os–NP/n–Decanol or n–Dodecanol Nanodispersions for p–Nitrophenol Reduction
Authors: Pîrțac Andreia , Nechifor Aurelia Cristina , Tanczos Szidonia-Katalin , Oprea Ovidiu Cristian , Grosu Alexandra Raluca , Matei Cristian , Grosu Vlad-Alexandru , Vasile Bogdan Ștefan , Albu Paul Constantin , Nechifor Gheorghe
Published: April 2024

Membrane materials with osmium nanoparticles have been recently reported for bulk membranes and supported composite membrane systems. In the present paper, a catalytic material based on osmium dispersed in n–decanol (nD) or n–dodecanol (nDD) is presented, which also works as an emulsion membrane. The hydrogenation of p–nitrophenol (PNP) is carried out in a reaction and separation column in which an emulsion in the acid-receiving phase is dispersed in an osmium nanodispersion in n–alcohols. The variables of the PNP conversion process and p–aminophenol (PAP) transport are as follows: the nature of the membrane alcohol, the flow regime, the pH difference between the source and receiving phases and the number of operating cycles. The conversion results are in all cases better for nD than nDD. The counter-current flow regime is superior to the co-current flow. Increasing the pH difference between the source and receiving phases amplifies the process. The number of operating cycles is limited to five, after which the regeneration of the membrane dispersion is required. The apparent catalytic rate constant (kapp) of the new catalytic material based on the emulsion membrane with the nanodispersion of osmium nanoparticles (0.1 × 10−3 s−1 for n–dodecanol and 0.9 × 10−3 s−1 for n–decanol) is lower by an order of magnitude compared to those based on adsorption on catalysts from the platinum metal group. The advantage of the tested membrane catalytic material is that it extracts p–aminophenol in the acid-receiving phase.
Internal Factors Affecting the Crystallization of the Lipid System: Triacylglycerol Structure, Composition, and Minor Components
Authors: Yang Dubing , Lee Yee-Ying , Lu Yuxia , Wang Yong , Zhang Zhen
Published: April 2024

The process of lipid crystallization influences the characteristics of lipid. By changing the chemical composition of the lipid system, the crystallization behavior could be controlled. This review elucidates the internal factors affecting lipid crystallization, including triacylglycerol (TAG) structure, TAG composition, and minor components. The influence of these factors on the TAG crystal polymorphic form, nanostructure, microstructure, and physical properties is discussed. The interplay of these factors collectively influences crystallization across various scales. Variations in fatty acid chain length, double bonds, and branching, along with their arrangement on the glycerol backbone, dictate molecular interactions within and between TAG molecules. High-melting-point TAG dominates crystallization, while liquid oil hinders the process but facilitates polymorphic transitions. Unique molecular interactions arise from specific TAG combinations, yielding molecular compounds with distinctive properties. Nanoscale crystallization is significantly impacted by liquid oil and minor components. The interaction between the TAG and minor components determines the influence of minor components on the crystallization process. In addition, future perspectives on better design and control of lipid crystallization are also presented.
Magnetic Nanoparticle Support with an Ultra-Thin Chitosan Layer Preserves the Catalytic Activity of the Immobilized Glucose Oxidase
Authors: Tikhonov Boris B. , Lisichkin Daniil R. , Sulman Alexandrina M. , Sidorov Alexander I. , Bykov Alexey V. , Lugovoy Yury V. , Karpenkov Alexey Y. , Bronstein Lyudmila M. , Matveeva Valentina G.
Published: April 2024

Here, we developed magnetically recoverable biocatalysts based on magnetite nanoparticles coated with an ultra-thin layer (about 0.9 nm) of chitosan (CS) ionically cross-linked by sodium tripolyphosphate (TPP). Excessive CS amounts were removed by multiple washings combined with magnetic separation. Glucose oxidase (GOx) was attached to the magnetic support via the interaction with N-hydroxysuccinimide (NHS) in the presence of carbodiimide (EDC) leading to a covalent amide bond. These steps result in the formation of the biocatalyst for D-glucose oxidation to D-gluconic acid to be used in the preparation of pharmaceuticals due to the benign character of the biocatalyst components. To choose the catalyst with the best catalytic performance, the amounts of CS, TPP, NHS, EDC, and GOx were varied. The optimal biocatalyst allowed for 100% relative catalytic activity. The immobilization of GOx and the magnetic character of the support prevents GOx and biocatalyst loss and allows for repeated use.
Electrochemical Detection of Cd2+, Pb2+, Cu2+ and Hg2+ with Sensors Based on Carbonaceous Nanomaterials and Fe3O4 Nanoparticles
Authors: Dinu (Iacob) Ancuța , Bounegru Alexandra Virginia , Iticescu Catalina , Georgescu Lucian P. , Apetrei Constantin
Published: April 2024

Two electrochemical sensors were developed in this study, with their preparations using two nanomaterials with remarkable properties, namely, carbon nanofibers (CNF) modified with Fe3O4 nanoparticles and multilayer carbon nanotubes (MWCNT) modified with Fe3O4 nanoparticles. The modified screen-printed electrodes (SPE) were thus named SPE/Fe3O4-CNF and SPE/Fe3O4-MWCNT and were used for the simultaneous detection of heavy metals (Cd2+, Pb2+, Cu2+ and Hg2+). The sensors have been spectrometrically and electrochemically characterized. The limits of detection of the SPE/Fe3O4-CNF sensor were 0.0615 μM, 0.0154 μM, 0.0320 μM and 0.0148 μM for Cd2+, Pb2+, Cu2+ and Hg2+, respectively, and 0.2719 μM, 0.3187 μM, 1.0436 μM and 0.9076 μM in the case of the SPE/ Fe3O4-MWCNT sensor (following optimization of the working parameters). Due to the modifying material, the results showed superior performance for the SPE/Fe3O4-CNF sensor, with extended linearity ranges and detection limits in the nanomolar range, compared to those of the SPE/Fe3O4-MWCNT sensor. For the quantification of heavy metal ions Cd2+, Pb2+, Cu2+ and Hg2+ with the SPE/Fe3O4-CNF sensor from real samples, the standard addition method was used because the values obtained for the recovery tests were good. The analysis of surface water samples from the Danube River has shown that the obtained values are significantly lower than the maximum limits allowed according to the quality standards specified by the United States Environmental Protection Agency (USEPA) and those of the World Health Organization (WHO). This research provides a complementary method based on electrochemical sensors for in situ monitoring of surface water quality, representing a useful tool in environmental studies.
The Impact of Acute Postoperative Pain in Developing Chronic Pain after Total Knee Arthroplasty
Authors: Knezevic Nebojsa Nick , Syed Osman , Kabir Christopher , Patel Aisha , Rao Shuai Isabel , Tharian Antony R.
Published: April 2024

While total knee arthroplasties (TKAs) are performed with the intent to reduce pain, chronic postsurgical pain (CPSP) is one of the most well-documented complications that can occur following surgery. This study aimed to assess whether perioperative factors, focusing on acute postsurgical pain and perioperative opioid consumption, were associated with the development of chronic postsurgical pain. Under general anesthesia, 108 patients underwent TKA and were treated postoperatively with a multimodal analgesia approach. Numeric Rating Scale (NRS) pain scores at rest and with movement were recorded on postoperative days 0–3, 7, 14, and 30. Patients were sent a survey to assess chronic pain at months 22–66, which was examined as a single-group post hoc analysis. Based on the responses, patients were either classified into the CPSP or non-CPSP patient group. Chronic postsurgical pain was defined as an NRS score ≥ 4 with movement and the presence of resting pain. The primary outcome was a change in NRS. There were no differences in NRS pain scores with movement in the first 30 days postoperatively between patients with CPSP and without CPSP. Each unit increase in resting pain on postoperative days 3 and 14 was associated with significantly greater odds of CPSP presence (OR = 1.52; OR = 1.61, respectively), with a trend towards greater odds of CPSP at days 7 and 30 (OR = 1.33; OR = 1.43, respectively). We found that very intense pain in the initial phase seems to be related to the development of CPSP after TKA.
Building Capacity and Advancing Regulatory Measures to Improve Food Environments in the Region of the Americas
Authors: Levis Carmen , Mejía Toro Carolina , Patiño Sofía Rincón Gallardo , Villalobos-Daniel Victor Eduardo , Spinillo Carla , Gomes Fabio da Silva
Published: April 2024

Noncommunicable diseases (NCDs) are the main cause of death globally (70%) and in the Region of the Americas (80%), and poor diets are a leading driver of NCDs. In response, the Pan American Health Organization (PAHO)/World Health Organization (WHO) introduced a set of evidence-based regulatory measures to help countries improve diets through the reduced consumption of processed and ultra-processed foods. This paper aims to describe the needs of and propose actions for key actors to advance these measures. A workshop was designed to assess member states’ regulatory capacity. A thematic analysis was conducted to analyze regional needs, successes and challenges. Thereafter, the Government Capacity-Building Framework for the prevention and control of NCDs was used to examine findings. The findings were organized in two sets: (i) PAHO/WHO actions to support member states and (ii) key actors’ actions to advance regulatory policies. The results show notable regulatory progress across the Region of the Americas. However, progress differs between countries, with opportunities to strengthen measures in most countries, mainly in conflict of interest management. The results identified important actions to strengthen the regulatory capacity of PAHO/WHO member states. To maximize momentum for these actions, timelines must be identified, and political commitment can be boosted by applying human rights-based and food system-wide approaches.
Nutritional Habits of Hungarian Older Adults
Authors: Soós Rita , Bakó Csilla , Gyebrovszki Ádám , Gordos Mónika , Csala Dávid , Ádám Zoltán , Wilhelm Márta
Published: April 2024

There are many nutritional changes that come with aging, mostly as consequences of health regression. Malnutrition and overweight often start with inadequate food consumption, followed by alterations in biochemical indices and body composition. In our study, we aimed to analyze the feeding habits and energy and nutrient intake of a Hungarian elderly population, focusing on macronutrient, water, fruit, and vegetable consumption while searching for possible nutritional factors leading to NCD and many other chronic diseases in this population. Two questionnaires were used. These were the Mini Nutritional Assessment (MNA) and one asking about nutritional habits, and a 3-day feeding diary was also filled. Subjects (n = 179, 111; females (F), 68 males (M), older than 50 years were recruited. Based on MNA results, 78 adults (43.57% of the studied population) were malnourished or at risk of malnutrition, although, according to BMI categories, 69% were overweight and 7.3% were obese among M, while 42.3% were overweight among F. The average daily meal number was diverse. The amount of people consuming fruit (11.7%) and vegetables (8.93%) several times a day was extremely low (15.3% of F and 4.4% of M). Daily fruit consumption in the whole sample was 79.3%. Overall, 36.3% consumed 1 L of liquid and 0.5 L of consumption was found in 15.1% of participants. A significant gender difference was found in water consumption, with F drinking more than M (p ≤ 0.01). In our sample, 27.93% of the respondents took dietary supplements. Further analysis and research are needed to explore the specific health implications of and reasons behind these findings.
Adding a Leafy Vegetable Fraction to Diets Decreases the Risk of Red Meat Mortality in MASLD Subjects: Results from the MICOL Cohort
Authors: Donghia Rossella , Tatoli Rossella , Campanella Angelo , Cuccaro Francesco , Bonfiglio Caterina , Giannelli Gianluigi
Published: April 2024

Background: Dietary guidelines recommend limiting red meat intake because it has been amply associated with increased cancer mortality, particularly in patients with liver conditions, such as metabolic dysfunction-associated fatty liver disease (MASLD). MASLD is the leading cause of liver dysfunction in the world today, and no specific treatment other than lifestyle correction has yet been established. The aim of this study was to explore the protective role of leafy vegetables when associated with high red meat consumption. Methods: The study cohort included 1646 participants assessed during the fourth recall of the MICOL study, subdivided into two groups based on red meat intake (≤50 g/die vs. >50 g/die), in order to conduct a cancer mortality analysis. The prevalence of subjects that consumed >50 g/die was only 15.73%. Leafy vegetable intake was categorized based on median g/die consumption, and it was combined with red meat intake. Conclusions: This is the first study to demonstrate that the consumption of about 30 g/die of leafy vegetables reduces the risk of mortality. A strong association with mortality was observed in subjects with MASLD, and the protective role of vegetables was demonstrated.
Analysis of Malnutrition among Children under Five Years across Contrasting Agroecosystems of Northwest Ethiopia: Application of Structural Equation Modeling
Authors: Wubetie Biruk Yazie , Tsunekawa Atsushi , Haregeweyn Nigussie , Tsubo Mitsuru , Nigussie Zerihun , Meshesha Taye Minichil , Abe Takeshi
Published: April 2024

Child malnutrition remains a public health challenge in developing countries, but a comprehensive understanding of its burden and its determinants in specific local contexts is generally lacking. This study examined the prevalence of malnutrition and its determinants among children aged <5 years across contrasting agroecosystems in northwest Ethiopia. A community-based cross-sectional study involving 400 respondents was employed. Data were collected through semi-structured questionnaires and anthropometric measurements, complemented with focus group discussions and key informant interviews. The direct and indirect effects of the determinants of malnutrition were examined using structural equation modeling (SEM). The overall prevalence of child malnutrition, measured using the Composite Index of Anthropometric Failure, was 49%, with notable variation across agroecosystems (from 36.1% [midland with red soil] to 59% [lowland and valley fragmented]). Disease experience had significant positive direct effects on malnutrition. Dietary intake had negative and significant total (direct and indirect) effects on malnutrition, partially mediated through disease experience. Serial mediation in SEM analysis revealed significant indirect relationships between malnutrition and food security, feeding and care practices, household environment, health services, maternal diet, maternal empowerment, household wealth, and nutrition-sensitive agricultural practices. In conclusion, child malnutrition was highly prevalent and higher among children in the lowland and valley fragmented agroecosystem, characterized by unfavorable agro-climatic conditions, lower wealth status, poor health services access, and higher disease (particularly malaria) exposure. This study demonstrates the dynamics and multifaceted nature of malnutrition, highlighting the importance of considering geographical differences when planning interventions for childhood malnutrition and its determinants.
Sustained Effectiveness of Upadacitinib in Moderate-to-Severe Atopic Dermatitis: A 48-Week Real-World Study
Authors: Hagino Teppei , Hamada Risa , Yoshida Mai , Saeki Hidehisa , Fujimoto Eita , Kanda Naoko
Published: April 2024

Clinical trials and real-world studies have shown the effectiveness of upadacitinib for treating rash and pruritus in patients with atopic dermatitis (AD). This study aimed to determine whether the early reduction in rash or pruritus at week 12 of upadacitinib treatment could be maintained at later treatment stages. This retrospective study involved 227 and 73 patients with moderate-to-severe AD treated with 15 and 30 mg upadacitinib daily, respectively. The eczema area and severity index (EASI) scores, peak pruritus numerical rating scale (PP-NRS), and investigator’s global assessment (IGA) were analyzed. At week 12, patients were divided into achievers and non-achievers of EASI 75, 90, 100, absolute EASI ≤ 2, IGA0/1, PP-NRS4, or absolute PP-NRS ≤ 1. Achievement rates for each endpoint were assessed at later time points (weeks 24, 36, and 48) in both groups. Week 12 achievers largely maintained their endpoint achievements until week 48, regardless of dosage (15 mg or 30 mg). Week 12 non-achievers saw an increasing achievement rate of EASI 75 until week 48. The initial reduction in rash and pruritus at week 12 persisted until week 48 with upadacitinib treatment, suggesting potential benefits for patients requiring prolonged treatment despite not achieving EASI 75 at week 12.
A Population Pharmacokinetic Study to Compare a Novel Empagliflozin L-Proline Formulation with Its Conventional Formulation in Healthy Subjects
Authors: Jiang Xu , Yu Kyung-Sang , Nam Dong Hyuk , Oh Jaeseong
Published: April 2024

Empagliflozin is a sodium–glucose cotransporter 2 (SGLT2) inhibitor that is commonly used for the treatment of type 2 diabetes mellitus (T2DM). CKD-370 was newly developed as a cocrystal formulation of empagliflozin with co-former L-proline, which has been confirmed to be bioequivalent in South Korea. This study aimed to quantify the differences in the absorption phase and pharmacokinetic (PK) parameters of two empagliflozin formulations in healthy subjects by using population PK analysis. The plasma concentration data of empagliflozin were obtained from two randomized, open-label, crossover, phase 1 clinical studies in healthy Korean subjects after a single-dose administration. A population PK model was constructed by using a nonlinear mixed-effects (NLME) approach (Monolix Suite 2021R1). Interindividual variability (IIV) and interoccasion variability (IOV) were investigated. The final model was evaluated by goodness-of-fit (GOF) diagnostic plots, visual predictive checks (VPCs), prediction errors, and bootstrapping. The PK of empagliflozin was adequately described with a two-compartment combined transit compartment model with first-order absorption and elimination. Log-transformed body weight significantly influenced systemic clearance (CL) and the volume of distribution in the peripheral compartment (V2) of empagliflozin. GOF plots, VPCs, prediction errors, and the bootstrapping of the final model suggested that the proposed model was adequate and robust, with good precision at different dose strengths. The cocrystal form did not affect the absorption phase of the drug, and the PK parameters were not affected by the different treatments.
Overview of Research on Leishmaniasis in Africa: Current Status, Diagnosis, Therapeutics, and Recent Advances Using By-Products of the Sargassaceae Family
Authors: Abdoul-Latif Fatouma Mohamed , Oumaskour Khadija , Abdallah Nadira , Ainane Ayoub , Houmed Aboubaker Ibrahim , Merito Ali , Mohamed Houda , Ainane Tarik
Published: April 2024

Leishmaniasis in Africa, which has been designated as a priority neglected tropical disease by various global organizations, exerts its impact on millions of individuals, primarily concentrated within this particular region of the world. As a result of the progressively grave epidemiological data, numerous governmental sectors and civil organizations have concentrated their endeavors on this widespread outbreak with the objective of devising appropriate remedies. This comprehensive examination delves into multiple facets of this parasitic ailment, scrutinizing the associated perils, diagnostic intricacies, and deficiencies within the existing therapeutic protocols. Despite the established efficacy of current treatments, they are not immune to deleterious incidents, particularly concerning toxicity and the emergence of parasitic resistance, thus accentuating the necessity of exploring alternative avenues. Consequently, this research not only encompasses conventional therapeutic approaches, but also extends its scope to encompass complementary and alternative medicinal techniques, thereby striving to identify innovative solutions. A particularly auspicious dimension of this study lies in the exploration of natural substances and by-products derived from some brown algae of the Sargassaceae family. These resources possess the potential to assume a pivotal role in the management of leishmaniasis.