bluuebunny/crossref_metadata_2025 huggingface dataset:
The Influence of Connectedness to Nature on Psychological Well-Being: Evidence from the Randomized Controlled Trial Play&Grow
Authors: Sobko Tanja , Brown Gavin T. L.
Published: May 2021

Urbanized children today have fewer opportunities to interact with nature which may lead to a greater risk of mental health problems. The objective of this randomized controlled trial was to investigate which particular changes in connectedness to nature (CN) would improve psychological well-being (PW) in young children. Six hundred and thirty-nine preschoolers (52.0% boys, age 34.9 ± 9.5 months) participated in Play&Grow, an early environmental education intervention. Children’s CN and PW were evaluated by parents before and after the program with validated measures; the CNI-PPC (four factors) and the SDQ, Strength and Difficulties questionnaire (five factors), respectively. The effectiveness of the intervention on the primary outcomes (CN, PW) as well as the relationship between them was analyzed in a repeated measures path model with intervention status as a causal predictor. Specific CN factors consistently increased ProSocial behavior and reduced Hyperactivity and Emotional problems. In summary, this study showed that the previously reported impact shifted from the total CN score to the specific CN factors. The Play&Grow intervention positively increased children’s CN and improved some aspects of psychological well-being in children which is a preliminary evidence of developmental benefits of connecting young children with nature. Our results indicate promising direction of action for the improvement of families’ psychological health.
Enhanced Growth Rate of Chemical Vapor Deposition Diamond Coating Motivated by Graphene Oxide
Authors: Zhou Fan , Chen Naichao , Ju Fasong
Published: May 2021

To improve the growth rate of chemical vapor deposition (CVD) diamond coating, increasing the chemical reaction rate is essential. A novel method of dispersing graphene oxide (GO) particles as adsorbent on the substrate prior to deposition was proposed, with which the diamond coating with large grain size and high thickness was deposited on the silicon nitride under the normal CVD environment. The as-deposited diamond coating was characterized by scanning electron microscopy (SEM), surface profilometer, atomic force microscope (AFM), Raman spectrum, and indentation. The surface morphologies showed that the GO particles were covered by a layer of diamond coating. The diamond coating without and with GO particles had growth rates of 1.10–1.38 and 1.50–2.94 μm h−1, respectively. No differences in the Raman spectra of the microcrystalline diamond (MCD) coatings without and with GO particles were found. Indentation tests suggested that GO particles could enhance the adhesive strength and the crack resistance of diamond coating, which may result from the large thickness and the strong adsorbed capacity of destructive energy. Hence, dispersing particles on the substrate can be regarded as a potential and alternative technique by accelerating the CVD chemical reaction to obtain desired diamond coating.
Activity and Safety of NAB-FOLFIRI and NAB-FOLFOX as First-Line Treatment for metastatic Pancreatic Cancer (NabucCO Study)
Authors: Giommoni Elisa , Maiello Evaristo , Vaccaro Vanja , Rondini Ermanno , Vivaldi Caterina , Tortora Giampaolo , Toppo Laura , Giordano Guido , Latiano Tiziana Pia , Lamperini Cinzia , Pillozzi Serena , Boni Luca , Antonuzzo Lorenzo , Di Costanzo Francesco
Published: May 2021

Background: Relevant improvement in first-line treatment of metastatic pancreatic cancer (mPC) was provided by FOLFIRINOX and by gemcitabine (gem) plus nab-paclitaxel (Nab-p) regimens. Regardless of the first-line treatment survival benefit, most patients survive less than 1 year. Aim: The objectives of this multicenter phase I/II study were to evaluate as first-line chemotherapy (CT) two modified regimens of FOLFIRINOX, replacing either oxaliplatin (Oxa) or irinotecan with Nab-p, in patients with mPC. Methods: The primary objectives of phase 1 were the definition of the dose limit binations, while for phase II they were the characterization of safety and activity of Nab-FOLFIRI and Nab-FOLFOX in mPC. Results: Sixty-three patients received Nab-FOLFIRI or Nab-FOLFOX in phase I. We defined MTD at 120 mg/m2 for Nab-p with FOLFIRI and 160 mg/m2 with FOLFOX. In phase II, we randomized 42 patients for each arm with the following results: (1) overall response rate (ORR) was 31% for both schedules; (2) a clinical benefit rate (CBR) of 69% and 71%; (3) 1-year survival was 41% and 50%; (4) progression free survival (PFS) was 6 months and 5.6 months; (5) median overall survival (OS) was 10.2 and 10.4 months for Nab-FOLFIRI and Nab-FOLFOX, respectively. (6) Neutropenia was the most common grade ≥3 adverse event in our regimens, significantly lower than that reported for the FOLFIRINOX triplet. Conclusion: Nab-FOLFIRI and Nab-FOLFOX might be hopeful first-line CT options for mPC patients, with promising activity and a good safety profile.
Predictors of Urgent Cancer Care Clinic and Emergency Department Visits for Individuals Diagnosed with Cancer
Authors: Decker Kathleen , Lambert Pascal , Galloway Katie , Bucher Oliver , Pitz Marshall , Goldenberg Benjamin , Singh Harminder , Kristjanson Mark , Fatoye Tunji , Bow Eric J.
Published: May 2021

In 2013, CancerCare Manitoba (CCMB) launched an urgent cancer care clinic (UCC) to meet the needs of individuals diagnosed with cancer experiencing acute complications of cancer or its treatment. This retrospective cohort study compared the characteristics of individuals diagnosed with cancer that visited the UCC to those who visited an emergency department (ED) and determined predictors of use. Multivariable logistic mixed models were run to predict an individual’s likelihood of visiting the UCC or an ED. Scaled Brier scores were calculated to determine how greatly each predictor impacted UCC or ED use. We found that UCC visits increased up to 4 months after eligibility to visit and then decreased. ED visits were highest immediately after eligibility and then decreased. The median number of hours between triage and discharge was 2 h for UCC visits and 9 h for ED visits. Chemotherapy had the strongest association with UCC visits, whereas ED visits prior to diagnosis had the strongest association with ED visits. Variables related to socioeconomic status were less strongly associated with UCC or ED visits. Future studies would be beneficial to planning service delivery and improving clinical outcomes and patient satisfaction.
How to Assess Shoulder Functionality: A Systematic Review of Existing Validated Outcome Measures
Authors: Aldon-Villegas Rocio , Ridao-Fernández Carmen , Torres-Enamorado Dolores , Chamorro-Moriana Gema
Published: May 2021

The objective of this review was to compile validated functional shoulder assessment tools and analyse the methodological quality of their validations. Secondarily, we aimed to provide a comparison of the tools, including parameter descriptions, indications/applications, languages and operating instructions, to choose the most suitable for future clinical and research approaches. A systematic review (PRISMA) was conducted using: PubMed, WoS Scopus, CINHAL, Dialnet and reference lists until 2020. The main criteria for inclusion were that papers were original studies of validated tools or validation studies. Pre-established tables showed tools, validations, items/components, etc. The QUADAS-2 and COSMIN-RB were used to assess the methodological quality of validations. Ultimately, 85 studies were selected, 32 tools and 111 validations. Risk of bias scored lower than applicability, and patient selection got the best scores (QUADAS-2). Internal consistency had the highest quality and PROMs development the lowest (COSMIN-RB). Responsiveness was the most analysed metric property. Modified UCLA and SST obtained the highest quality in shoulder instability surgery, and SPADI in pain. The most approached topic was activities of daily living (81%). We compiled 32 validated functional shoulder assessment tools, and conducted an analysis of the methodological quality of 111 validations associated with them. Modified UCLA and SST showed the highest methodological quality in instability surgery and SPADI in pain.
Impact of the Noise Penalty Factor on Quantification in Bayesian Penalized Likelihood (Q.Clear) Reconstructions of 68Ga-PSMA PET/CT Scans
Authors: Rijnsdorp Sjoerd , Roef Mark , Arends Albert
Published: May 2021

Functional imaging with 68Ga prostate-specific membrane antigen (PSMA) and positron emission tomography (PET) can fulfill an important role in treatment selection and adjustment in prostate cancer. This article focusses on quantitative assessment of 68Ga-PSMA-PET. The effect of various parameters on standardized uptake values (SUVs) is explored, and an optimal Bayesian penalized likelihood (BPL) reconstruction is suggested. PET acquisitions of two phantoms consisting of a background compartment and spheres with diameter 4 mm to 37 mm, both filled with solutions of 68Ga in water, were performed with a GE Discovery 710 PET/CT scanner. Recovery coefficients (RCs) in multiple reconstructions with varying noise penalty factors and acquisition times were determined and analyzed. Apparent recovery coefficients of spheres with a diameter smaller than 17 mm were significantly lower than those of spheres with a diameter of 17 mm and bigger (p < 0.001) for a tumor-to-background (T/B) ratio of 10:1 and a scan time of 10 min per bed position. With a T/B ratio of 10:1, the four largest spheres exhibit significantly higher RCs than those with a T/B ratio of 20:1 (p < 0.0001). For spheres with a diameter of 8 mm and less, alignment with the voxel grid potentially affects the RC. Evaluation of PET/CT scans using (semi-)quantitative measures such as SUVs should be performed with great caution, as SUVs are influenced by scanning and reconstruction parameters. Based on the evaluation of multiple reconstructions with different β of phantom scans, an intermediate β (600) is suggested as the optimal value for the reconstruction of clinical 68Ga-PSMA PET/CT scans, considering that both detectability and reproducibility are relevant.
Symmetric Reconstruction of Functional Liver Segments and Cross-Individual Correspondence of Hepatectomy
Authors: Le Doan Cong , Chansangrat Jirapa , Keeratibharat Nattawut , Horkaew Paramate
Published: May 2021

Accurate localization and analyses of functional liver segments are crucial in devising various surgical procedures, including hepatectomy. To this end, they require the extraction of a liver from computed tomography, and then the identification of resection correspondence between individuals. The first part is usually impeded by inherent deficiencies, as present in medical images, and vast anatomical variations across subjects. While the model-based approach is found viable to tackle both issues, it is often undermined by an inadequate number of labeled samples, to capture all plausible variations. To address segmentation problems by balancing between accuracy, resource consumption, and data availability, this paper presents an efficient method for liver segmentation based on a graph-cut algorithm. One of its main novelties is the incorporation of a feature preserving a metric for boundary separation. Intuitive anatomical constraints are imposed to ensure valid extraction. The second part involves the symmetric conformal parameterization of the extracted liver surface onto a genus-0 domain. Provided with a few landmarks specified on two livers, we demonstrated that, by using a modified Beltrami differential, not only could they be non-rigidly registered, but also the hepatectomy on one liver could be envisioned on another. The merits of the proposed scheme were elucidated by both visual and numerical assessments on a standard MICCAI SLIVER07 dataset.
The Evolving Landscape of Chronic Lymphocytic Leukemia on Diagnosis, Prognosis and Treatment
Authors: Pérez-Carretero Claudia , González-Gascón-y-Marín Isabel , Rodríguez-Vicente Ana E. , Quijada-Álamo Miguel , Hernández-Rivas José-Ángel , Hernández-Sánchez María , Hernández-Rivas Jesús María
Published: May 2021

The knowledge of chronic lymphocytic leukemia (CLL) has progressively deepened during the last forty years. Research activities and clinical studies have been remarkably fruitful in novel findings elucidating multiple aspects of the pathogenesis of the disease, improving CLL diagnosis, prognosis and treatment. Whereas the diagnostic criteria for CLL have not substantially changed over time, prognostication has experienced an expansion with the identification of new biological and genetic biomarkers. Thanks to next-generation sequencing (NGS), an unprecedented number of gene mutations were identified with potential prognostic and predictive value in the 2010s, although significant work on their validation is still required before they can be used in a routine clinical setting. In terms of treatment, there has been an impressive explosion of new approaches based on targeted therapies for CLL patients during the last decade. In this current chemotherapy-free era, BCR and BCL2 inhibitors have changed the management of CLL patients and clearly improved their prognosis and quality of life. In this review, we provide an overview of these novel advances, as well as point out questions that should be further addressed to continue improving the outcomes of patients.
Training Data Selection and Optimal Sensor Placement for Deep-Learning-Based Sparse Inertial Sensor Human Posture Reconstruction
Authors: Zheng Zhaolong , Ma Hao , Yan Weichao , Liu Haoyang , Yang Zaiyue
Published: May 2021

Although commercial motion-capture systems have been widely used in various applications, the complex setup limits their application scenarios for ordinary consumers. To overcome the drawbacks of wearability, human posture reconstruction based on a few wearable sensors have been actively studied in recent years. In this paper, we propose a deep-learning-based sparse inertial sensor human posture reconstruction method. This method uses bidirectional recurrent neural network (Bi-RNN) to build an a priori model from a large motion dataset to build human motion, thereby the low-dimensional motion measurements are mapped to whole-body posture. To improve the motion reconstruction performance for specific application scenarios, two fundamental problems in the model construction are investigated: training data selection and sparse sensor placement. The problem of deep-learning training data selection is to select independent and identically distributed (IID) data for a certain scenario from the accumulated imbalanced motion dataset with sufficient information. We formulate the data selection into an optimization problem to obtain continuous and IID data segments, which comply with a small reference dataset collected from the target scenario. A two-step heuristic algorithm is proposed to solve the data selection problem. On the other hand, the optimal sensor placement problem is studied to exploit most information from partial observation of human movement. A method for evaluating the motion information amount of any group of wearable inertial sensors based on mutual information is proposed, and a greedy searching method is adopted to obtain the approximate optimal sensor placement of a given sensor number, so that the maximum motion information and minimum redundancy is achieved. Finally, the human posture reconstruction performance is evaluated with different training data and sensor placement selection methods, and experimental results show that the proposed method takes advantages in both posture reconstruction accuracy and model training time. In the 6 sensors configuration, the posture reconstruction errors of our model for walking, running, and playing basketball are 7.25°, 8.84°, and 14.13°, respectively.
On Explaining Quantum Correlations: Causal vs. Non-Causal
Authors: Felline Laura
Published: May 2021

At the basis of the problem of explaining non-local quantum correlations lies the tension between two factors: on the one hand, the natural interpretation of correlations as the manifestation of a causal relation; on the other, the resistance on the part of the physics underlying said correlations to adjust to the most essential features of a pre-theoretic notion of causation. In this paper, I argue for the rejection of the first horn of the dilemma, i.e., the assumption that quantum correlations call for a causal explanation. The paper is divided into two parts. The first, destructive, part provides a critical overview of the enterprise of causally interpreting non-local quantum correlations, with the aim of warning against the temptation of an account of causation claiming to cover such correlations ‘for free’. The second, constructive, part introduces the so-called structural explanation (a variety of non-causal explanation that shows how the explanandum is the manifestation of a fundamental structure of the world) and argues that quantum correlations might be explained structurally in the context of an information-theoretic approach to QT.
Linking Federal Forest Restoration with Wood Utilization: Modeling Biomass Prices and Analyzing Forest Restoration Costs in the Northern Sierra Nevada
Authors: Swezy Camille , Bailey John , Chung Woodam
Published: May 2021

Over half of California’s forestland is managed by the US Forest Service, and the agency has identified a need to scale up forest restoration treatments in the state to one million acres per year by 2025. However, the high costs of mechanical fuel reduction and lack of markets for biomass pose significant barriers to accomplishing this target. The objectives of this case study were: (1) to identify costs of forest restoration treatments on federally-managed land in the Northern Sierra under a variety of harvesting scenarios and haul distances to biomass facilities, and (2) to understand what market prices for biomass must be offered to support such efforts. We modeled silvicultural prescription and harvesting options, machine productivity and costs, and transportation costs to assess economic thresholds. Biomass harvest, chip, and haul costs ranged from $55/bone dry ton to $118/bone dry ton, depending on the harvesting system scenario and distance from the biomass disposal site. Results suggest that the cost of forest restoration far exceeds current market prices for biomass, and additional investment is needed to adequately pay for federal forest restoration in California. Additional takeaways include that biomass outlets closer to supply sources can reduce both haul costs and production costs, and local wood utilization campuses can play a key role in supporting forest restoration.
Effect of Phase Change Materials on the Thermal Performance of Residential Building Located in Different Cities of a Tropical Rainforest Climate Zone
Authors: Sheriyev Almas , Memon Shazim Ali , Adilkhanova Indira , Kim Jong
Published: May 2021

This study aims to investigate the thermal performance of PCM and PCM combined with nighttime natural (NV) and mechanical ventilation (MV) applied to a residential building located in eight cities of tropical rainforest climate zone (Af). The analysis was accomplished using numerical simulations and developing a unique methodology for selecting the PCM melting temperature based on the thermal comfort limits. The thermal performance of the PCM integrated building was quantitatively evaluated using the concept of peak temperature drop. Additionally, a novel indicator of Total Temperature Drop (TTD) was introduced to determine the overall impact of the PCM and PCM combined with NV/MV on the thermal comfort conditions inside the building. The results showed that PCM 28 was the most efficient in improving the thermal performance of the building located in the Af climate zone, achieving a TTD of up to 356 °C per year. The usage of PCM 28 combined with nighttime natural ventilation improved the TTD values by up to 15%, whereas the integration of PCM 28 combined with mechanical ventilation resulted in a TTD values increase of up to 45%. Conclusively, mechanical ventilation showed its superiority over natural ventilation in the tropical rainforest climate, and PCM 28 applied together with mechanical ventilation could be used as the optimum combination for the whole climate zone.
Developing a Cold Accumulator with a Capsule Bed Containing Water as a Phase-Change Material
Authors: Sekret Robert , Starzec Przemysław
Published: May 2021

The paper presents the investigation of a prototype cold accumulator using water–ice latent heat for the cold storage process. The concept of the cold accumulator was based on a 200-L-capacity cylindrical storage tank in which spherical capsules filled with water were placed. Beds of polypropylene capsules with diameters of 80 mm, 70 mm, and 60 mm were used in the tests. The cold accumulator operated with a water–air heat pump. Based on the test results, the following parameters were calculated: the cooling capacity, cooling power, energy efficiency of the cold storage, and energy efficiency ratio (EER) of the accumulator. The obtained measurement results were described with mathematical relationships (allowing for measurement error) using criterial numbers and the developed “Research Stand Factor Number” (RSFN) index. It has been found that, for the prototype cold accumulator under investigation, the maximum values of the cooling capacity (17 kWh or 85.3 kWh per cubic meter of the accumulator), energy efficiency (0.99), and EER (4.8) occur for an RSFN of 144·10−4. The optimal conditions for the operation of the prototype cold accumulator were the closest to laboratory tests conducted for a bed with capsules with a diameter of 70 mm and a mass flow of the water–glycol mixture flowing between the accumulator and the heat pump of 0.084 kg/s. During the tests, no significant problems with the operation of the prototype cold accumulator were found.
Iodide Electrolyte-Based Hybrid Supercapacitor for Compact Photo-Rechargeable Energy Storage System Utilising Silicon Solar Cells
Authors: Skunik-Nuckowska Magdalena , Rączka Patryk , Lubera Justyna , Mroziewicz Aleksandra A. , Dyjak Sławomir , Kulesza Paweł J. , Plebankiewicz Ireneusz , Bogdanowicz Krzysztof A. , Iwan Agnieszka
Published: May 2021

The one of the most important issues in constructing light-harvesting photovoltaic (PV) systems with a charge storage element is its reliable and uninterrupted use in highly variable and weather-dependent conditions in everyday applications. Herein, we report the construction and applicability evaluation of a ready-to-use portable solar charger comprising a silicon solar cell and an enhanced energy hybrid supercapacitor using activated carbon electrodes and iodide-based aqueous electrolyte to stabilise the PV power under fluctuating light conditions. The optimised electrode/electrolyte combination of a supercapacitor was used for the construction of a 60 F/3 V module by a proper adjustment of the series and parallel connections between the CR2032 coin cells. The final photo-rechargeable device was tested as a potential supporting system for pulse electronic applications under various laboratory conditions (temperature of 15 and 25 °C, solar irradiation of 600 and 1000 W m−2).
Impact of Geometry of Toothed Segments of the Innovative KOMTRACK Longwall Shearer Haulage System on Load and Slip during the Travel of a Track Wheel
Authors: Kotwica Krzysztof , Stopka Grzegorz , Kalita Marek , Bałaga Dominik , Siegmund Michał
Published: May 2021

Longwall shearers operating in the underground mine workings move along the longwall face along the conveyor troughs. The haulage system, which is made up of two kinematic pairs in the form of track wheels installed in shearer movers, cooperating with the toothed route built in the conveyor’s throughs, is responsible for moving the shearer. The currently used solutions of longwall shearers’ haulage systems do not ensure proper cooperation of the track wheels with toothed segments, which results in failures and breakdowns in the operation of the longwall systems, causing significant financial losses. Rigid solution of the gear components used is the reason. The solution of the flexible toothed segment, allowing it to adapt to the longitudinal and transverse curvature of the AFC (armored face conveyor) route during cooperation with the track wheel, was developed as part of the research project jointly implemented by KOMAG Institute of Mining Technology, AGH University of Science and Technology, Łukasiewicz Research Network–Cracow Institute of Technology, Specodlew Innovative Foundry Company and Polish Mining Group Inc., co-financed by the European Regional Development Fund (contract no. POIR.04.01.04-00-0068/17). The general design and principle of operation of the suggested KOMTRACK system is given. The results of the comparative simulations and analyses are presented. The load and slip values during the cooperation of the track wheels with the standard and new suggested toothed segment were estimated. The effectiveness of cooperation in the shearer movement along a disturbed conveyor route was also compared.
The Comparison of Solar-Powered Hydrogen Closed-Cycle System Capacities for Selected Locations
Authors: Solomin Evgeny , Selvanathan Shanmuga Priya , Kumarasamy Sudhakar , Kovalyov Anton , Maddappa Srinivasa Ramyashree
Published: May 2021

The exhaustion of fossil fuels causes decarbonized industries to be powered by renewable energy sources and, owing to their intermittent nature, it is important to devise an efficient energy storage method. To make them more sustainable, a storage system is required. Modern electricity storage systems are based on different types of chemical batteries, electromechanical devices, and hydrogen power plants. However, the parameters of power plant components vary from one geographical location to another. The idea of the present research is to compare the composition of a solar-powered hydrogen processing closed-cycle power plant among the selected geographical locations (Russia, India, and Australia), assuming the same power consumption conditions, but different insolation conditions, and thus the hydrogen equipment capacity accordingly. The number of solar modules in an array is different, thus the required hydrogen tank capacity is also different. The comparison of equipment requires building an uninterrupted power supply for the selected geographical locations, which shows that the capacity of the equipment components would be significantly different. These numbers may serve as the base for further economic calculations of energy cost.
Gamma-Ray Modified Polymer/Clay Composites: Synthesis, Characterization, and Formulation Optimization Using Multivariate Calculus and Graph Theory
Authors: Bakhsh Ahmed A.
Published: May 2021

To enhance the oxidation strength and crosslinking yield of ultrahigh molecular weight polyethylene (UHMWPE), its composites were prepared by mixing 1%, 2%, and 3% (by wt.) of magnesium silicate hydrous (sepiolite) during this study. These composites were irradiated with 25 kGy and 50 kGy of irradiation doses in the open air. Subsequent to irradiation, the composites were characterized for updates in structure, oxidation strength, and degree of crosslinking while estimating the values of oxidation index (OI), crosslink density (Gx), and percent crystallinity (Xc), respectively. The reaction of modified sepiolite (SP) on irradiating UHMWPE/SP composites was evident from the origination of peaks at Si-O, O-Si-O, Si-O-Si, and Mg-OH and stretching vibration at 974 cm−1, 1014 cm−1, and 1080 cm−1, respectively. In addition, the moderate negative correlation of OI (−0.46) and strong positive correlation of Gx (0.87) with the absorbed dose, made obvious from correlation analysis, confirmed the effectiveness of SP in enhancing the oxidation strength and crosslink density of UHMWPE. Furthermore, cluster analysis (CA) grouped the composites as low, moderate, and best based on dissimilarities, i.e., oxidation strength and crosslink density, which was further confirmed by principal component analysis (PCA). PCA also revealed that the OI, Gx, and absorbed dose were the active variables for this best group. After confirming the effectiveness of SP (as an active filler for enhancing the oxidation strength and crosslink density of UHMWPE) and recognizing the OI, Gx, and absorbed dose as active variables, the next step was to determine the necessary minimum amount of SP concentration and radiation dose required for the composite that outperforms all others. For this, a parametric graph theory and matrix approach was employed to rank the composites of the best group, revealing that the UHMWPE/SP composite with 1% (by wt.) of Si12O30Mg8(OH)4(H2O)4·8H2O and irradiated with 50 kGy of irradiation dose was the most suitable choice of all existing alternatives tested in this study. Although this is the first attempt, to the best of our knowledge, where a smart approach using multivariate calculus and decision-making tools was utilized for figuring the best UHMWPE composite formulation along with appropriate treatment dose, the results and methodology could be extended for any polymer of industrial scale, such as those used in medical implants, defense armor, bulletproof jackets, etc.
A Collaborative Merging Strategy with Lane Changing in Multilane Freeway On-Ramp Area with V2X Network
Authors: Shi Yanjun , Yu Hao , Guo Yijia , Yuan Zhiheng
Published: May 2021

The merging area of the freeway is an area with a high incidence of traffic accidents. With the development of connected and automated vehicles (CAVs) and V2X technology, the traffic efficiency of freeway ramp areas has been significantly improved. However, current research mostly focuses on merging a single mainline lane and ramp, and there are few cases of multiple lanes. In this paper, we present a collaborative merging model with a rule-based lane-changing strategy in a V2X environment. First, the vehicle selects the appropriate gap to change lanes safely without affecting other vehicles. Meanwhile, we established a linear time discrete model to optimize the trajectory of vehicles in real-time. Finally, the proposed model and strategy were implemented in SUMO and Python. The simulation results showed that the merging model we proposed based on the lane-changing strategy had good performance in terms of the number of stops, average delay, and average speed.
Calibration Method for the Determination of the FAME and HVO Contents in Fossil Diesel Blends Using NIR Spectroscopy
Authors: Wikberg Elena , Heikkilä Sonja , Sirviö Katriina , Välisuo Petri , Niemi Seppo , Niemi Antti
Published: May 2021

The European diesel fuel standard, EN590, allows a 7% (V/V) biodiesel (FAME) addition to automotive diesel fuel. The allowed addition of renewable diesel (HVO) to fossil diesel is not defined, as long as the properties of the fuel blend still meet the requirements of the standard. However, it is important to analyze the biofuels’ content in diesel fuel blends. In this article, a development procedure of a calibration method for quantification of the HVO and FAME contents in fossil diesel blends using near-infrared (NIR) spectroscopy is presented. The analytical range of quantification of biodiesel content is from 0 to 10% (V/V) and of renewable diesel content from 0 to 20% (V/V). The partial least squares (PLS) regression method for multivariable data analysis and construction of the calibration models were used to create the calibration method. The constructed PLS models obtained prediction results for all diesel fuel blends with root mean square error of prediction (RMSEP) values of 2.66% (V/V) for the HVO content quantification and 0.18% (V/V) for quantification of the FAME content. This article concludes that the calibration method is acceptable for laboratory applications in practice.
Collaboration and Gender Focality in Stag Hunt Bargaining
Authors: Guarin Geraldine , Babin J. Jobu
Published: May 2021

Knowing the gender of a counterpart can be focal in the willingness to collaborate in team settings that resemble the classic coordination problem. This paper explores whether knowing a co-worker’s gender affects coordination on the mutually beneficial outcome in a socially risky environment. In an experimental setting, subjects play a one-shot stag hunt game framed as a collaborative task in which they can “work together” or “work alone.” We exogenously vary whether workers know the gender of their counterparts pre-play. When gender is revealed, female players tend to gravitate to collaboration and efficient coordination regardless of the knowledge. Males, when knowingly paired with another male, tend to collaborate less, and thus, are less likely to coordinate on the Pareto optimal outcome. These results demonstrate one way that gender focality can lead to inefficient outcomes and provide insight for organizations looking to induce collaboration among workers.
Impacts of Tooth Loss on OHRQoL in an Adult Population in Cape Town, South Africa
Authors: Kimmie-Dhansay Faheema , Pontes Carla Cruvinel , Chikte Usuf M. E. , Chinhenzva Albert , Erasmus Rajiv T. , Kengne Andre Pascal , Matsha Tandi E.
Published: May 2021

(1) Background: Tooth loss is an important component of the global burden of oral disease, greatly reducing the quality of life of those affected. Tooth loss can also affect diet and subsequent incidences of lifestyle diseases, such as hypertension and metabolic syndromes. This study aimed to evaluate the oral health-related quality of life (OHRQoL) score using the oral impacts on daily performance (OIDP) index in relation to tooth loss patterns among adults. (2) Methods: From 2014 to 2016, a cross-sectional study was conducted on adults living in Bellville South, Cape Town, South Africa. The OHRQoL measure was used to evaluate the impact of tooth loss. (3) Results: A total of 1615 participants were included, and 143 (8.85%) had at least one impact (OIDP > 0). Males were less likely to experience at least one impact compared to the females, OR=0.6, 95% C.I.: 0.385 to 0.942, p = 0.026. Those participants who did not seek dental help due to financial constraints were 6.54 (4.49 to 9.54) times more likely to experience at least one impact, p < 0.001. (4) Conclusions: Tooth loss did not impact the OHRQoL of these subjects. There was no difference in the reported odds for participants experiencing at least one oral impact with the loss of their four anterior teeth, the loss of their posterior occlusal pairs, or the loss of their other teeth.
A Salivary Odorant-Binding Protein Mediates Nilaparvata lugens Feeding and Host Plant Phytohormone Suppression
Authors: Liu Hao , Wang Chao , Qiu Chang-Lai , Shi Jin-Hua , Sun Ze , Hu Xin-Jun , Liu Le , Wang Man-Qun
Published: May 2021

Odorant-binding proteins (OBPs) typically act as transporters of odor molecules and play an important role in insect host location. Here, we identified an OBP in brown planthopper (BPH) Nilaparvata lugens salivary glands via transcriptome sequencing. Real-time quantitative PCR and Western blotting analysis results showed that NlugOBP11 was highly expressed in salivary glands and secreted into rice plant during feeding, suggesting that it assists in BPH feeding on rice. Functional analysis in N. lugens saliva revealed that silencing this gene by RNA interference decreased the BPH stylet performance in the phloem of rice plants, reduced sap sucking, and ultimately led to insect death. Moreover, overexpression of NlugOBP11 in rice protoplasts or Nicotiana benthamiana leaves inhibited the production of defense-related signaling molecule salicylic acid in rice plant. The results demonstrate that NlugOBP11 is not only essential for BPH feeding, but also acts as an effector that inhibits plant defense.
Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues
Authors: Morisseau Christophe , Kodani Sean D. , Kamita Shizuo G. , Yang Jun , Lee Kin Sing Stephen , Hammock Bruce D.
Published: May 2021

Epoxy-fatty acids (EpFAs) are endogenous lipid mediators that have a large breadth of biological activities, including the regulation of blood pressure, inflammation, angiogenesis, and pain perception. For the past 20 years, soluble epoxide hydrolase (sEH) has been recognized as the primary enzyme for degrading EpFAs in vivo. The sEH converts EpFAs to the generally less biologically active 1,2-diols, which are quickly eliminated from the body. Thus, inhibitors of sEH are being developed as potential drug therapeutics for various diseases including neuropathic pain. Recent findings suggest that other epoxide hydrolases (EHs) such as microsomal epoxide hydrolase (mEH) and epoxide hydrolase-3 (EH3) can contribute significantly to the in vivo metabolism of EpFAs. In this study, we used two complementary approaches to probe the relative importance of sEH, mEH, and EH3 in 15 human tissue extracts: hydrolysis of 14,15-EET and 13,14-EDP using selective inhibitors and protein quantification. The sEH hydrolyzed the majority of EpFAs in all of the tissues investigated, mEH hydrolyzed a significant portion of EpFAs in several tissues, whereas no significant role in EpFAs metabolism was observed for EH3. Our findings indicate that residual mEH activity could limit the therapeutic efficacy of sEH inhibition in certain organs.
Exosomal microRNAs as Biomarkers and Therapeutic Targets for Hepatocellular Carcinoma
Authors: Sorop Andrei , Constantinescu Diana , Cojocaru Florentina , Dinischiotu Anca , Cucu Dana , Dima Simona Olimpia
Published: May 2021

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide and the second most common cause of cancer-related death globally. This type of liver cancer is frequently detected at a late stage by current biomarkers because of the high clinical and biological heterogeneity of HCC tumours. From a plethora of molecules and cellular compounds, small nanoparticles with an endosomal origin are valuable cancer biomarkers or cargos for novel treatments. Despite their small sizes, in the range of 40–150 nm, these particles are delimited by a lipid bilayer membrane with a specific lipid composition and carry functional information—RNA, proteins, miRNAs, long non-coding RNAs (lncRNAs), or DNA fragments. This review summarizes the role of exosomal microRNA (miRNA) species as biomarkers in HCC therapy. After we briefly introduce the exosome biogenesis and the methods of isolation and characterization, we discuss miRNA’s correlation with the diagnosis and prognosis of HCC, either as single miRNA species, or as specific panels with greater clinical impact. We also review the role of exosomal miRNAs in the tumourigenic process and in the cell communication pathways through the delivery of cargos, including proteins or specific drugs.
Is LRP2 Involved in Leptin Transport over the Blood-Brain Barrier and Development of Obesity?
Authors: Sandin Elvira S. , Folberth Julica , Müller-Fielitz Helge , Pietrzik Claus U. , Herold Elisabeth , Willnow Thomas E. , Pfluger Paul T. , Nogueiras Ruben , Prevot Vincent , Krey Thomas , Schwaninger Markus
Published: May 2021

The mechanisms underlying the transport of leptin into the brain are still largely unclear. While the leptin receptor has been implicated in the transport process, recent evidence has suggested an additional role of LRP2 (megalin). To evaluate the function of LRP2 for leptin transport across the blood-brain barrier (BBB), we developed a novel leptin-luciferase fusion protein (pLG), which stimulated leptin signaling and was transported in an in vitro BBB model based on porcine endothelial cells. The LRP inhibitor RAP did not affect leptin transport, arguing against a role of LRP2. In line with this, the selective deletion of LRP2 in brain endothelial cells and epithelial cells of the choroid plexus did not influence bodyweight, body composition, food intake, or energy expenditure of mice. These findings suggest that LRP2 at the BBB is not involved in the transport of leptin into the brain, nor in the development of obesity as has previously been described.
Does Genetic Predisposition Contribute to the Exacerbation of COVID-19 Symptoms in Individuals with Comorbidities and Explain the Huge Mortality Disparity between the East and the West?
Authors: Yamamoto Naoki , Yamamoto Rain , Ariumi Yasuo , Mizokami Masashi , Shimotohno Kunitada , Yoshikura Hiroshi
Published: May 2021

The elderly and patients with several comorbidities experience more severe cases of coronavirus disease 2019 (COVID-19) than healthy patients without underlying medical conditions. However, it is unclear why these people are prone to developing alveolar pneumonia, rapid exacerbations, and death. Therefore, we hypothesized that people with comorbidities may have a genetic predisposition that makes them more vulnerable to various factors; for example, they are likely to become more severely ill when infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). To test this hypothesis, we searched the literature extensively. Polymorphisms of genes, such as those that encode angiotensin-converting enzyme 1 (ACE1), have been associated with numerous comorbidities, such as cardiovascular disease, hypertension, diabetes, chronic kidney disease, and obesity, and there are potential mechanisms to explain these associations (e.g., DD-type carriers have greater ACE1 activity, and patients with a genetic alpha-1 anti-trypsin (AAT) deficiency lack control over inflammatory mediators). Since comorbidities are associated with chronic inflammation and are closely related to the renin–angiotensin–aldosterone system (RAAS), these individuals may already have a mild ACE1/ACE2 imbalance before viral infection, which increases their risk for developing severe cases of COVID-19. However, there is still much debate about the association between ACE1 D/I polymorphism and comorbidities. The best explanation for this discrepancy could be that the D allele and DD subtypes are associated with comorbidities, but the DD genotype alone does not have an exceptionally large effect. This is also expected since the ACE1 D/I polymorphism is only an intron marker. We also discuss how polymorphisms of AAT and other genes are involved in comorbidities and the severity of SARS-CoV-2 infection. Presumably, a combination of multiple genes and non-genetic factors is involved in the establishment of comorbidities and aggravation of COVID-19.
The Defibrillation Conundrum: New Insights into the Mechanisms of Shock-Related Myocardial Injury Sustained from a Life-Saving Therapy
Authors: Clementy Nicolas , Bodin Alexandre , Bisson Arnaud , Teixeira-Gomes Ana-Paula , Roger Sebastien , Angoulvant Denis , Labas Valérie , Babuty Dominique
Published: May 2021

Implantable cardiac defibrillators (ICDs) are recommended to prevent the risk of sudden cardiac death. However, shocks are associated with an increased mortality with a dose response effect, and a strategy of reducing electrical therapy burden improves the prognosis of implanted patients. We review the mechanisms of defibrillation and its consequences, including cell damage, metabolic remodeling, calcium metabolism anomalies, and inflammatory and pro-fibrotic remodeling. Electrical shocks do save lives, but also promote myocardial stunning, heart failure, and pro-arrhythmic effects as seen in electrical storms. Limiting unnecessary implantations and therapies and proposing new methods of defibrillation in the future are recommended.
Glutathione in the Brain
Authors: Aoyama Koji
Published: May 2021

Glutathione (GSH) is the most abundant non-protein thiol, and plays crucial roles in the antioxidant defense system and the maintenance of redox homeostasis in neurons. GSH depletion in the brain is a common finding in patients with neurodegenerative diseases, such as Alzheimer’s disease and Parkinson’s disease, and can cause neurodegeneration prior to disease onset. Excitatory amino acid carrier 1 (EAAC1), a sodium-dependent glutamate/cysteine transporter that is selectively present in neurons, plays a central role in the regulation of neuronal GSH production. The expression of EAAC1 is posttranslationally controlled by the glutamate transporter-associated protein 3–18 (GTRAP3-18) or miR-96-5p in neurons. The regulatory mechanism of neuronal GSH production mediated by EAAC1 may be a new target in therapeutic strategies for these neurodegenerative diseases. This review describes the regulatory mechanism of neuronal GSH production and its potential therapeutic application in the treatment of neurodegenerative diseases.
Assessment of TSPAN Expression Profile and Their Role in the VSCC Prognosis
Authors: Ferreira Kelly Pedrozo , de Almeida Bruna Cristine , dos Anjos Laura Gonzalez , Baiocchi Glauco , Soares Fernando Augusto , Rocha Rafael Malagoli , Baracat Edmund Chada , Dobroff Andrey Senos , Carvalho Katia Candido
Published: May 2021

The role and prognostic value of tetraspanins (TSPANs) in vulvar squamous cell carcinoma (VSCC) remain poorly understood. We sought to primarily determine, at both the molecular and tissue level, the expression profile of the TSPANs CD9, CD63, CD81, and CD82 in archived VSCC samples (n = 117) and further investigate their clinical relevance as prognostic markers. Our studies led us to identify CD63 as the most highly expressed TSPAN, at the gene and protein levels. Multicomparison studies also revealed that the expression of CD9 was associated with tumor size, whereas CD63 upregulation was associated with histological diagnosis and vascular invasion. Moreover, low expression of CD81 and CD82 was associated with worse prognosis. To determine the role of TSPANs in VSCC at the cellular level, we assessed the mRNA levels of CD63 and CD82 in established metastatic (SW962) and non-metastatic (SW954) VSCC human cell lines. CD82 was found to be downregulated in SW962 cells, thus supporting its metastasis suppressor role. However, CD63 was significantly upregulated in both cell lines. Silencing of CD63 by siRNA led to a significant decrease in proliferation of both SW954 and SW962. Furthermore, in SW962 particularly, CD63-siRNA also remarkably inhibited cell migration. Altogether, our data suggest that the differential expression of TSPANs represents an important feature for prognosis of VSCC patients and indicates that CD63 and CD82 are likely potential therapeutic targets in VSCC.
Trichodermin Induces G0/G1 Cell Cycle Arrest by Inhibiting c-Myc in Ovarian Cancer Cells and Tumor Xenograft-Bearing Mice
Authors: Gao Ying , Miles Sarah L. , Dasgupta Piyali , Rankin Gary O. , Cutler Stephen , Chen Yi Charlie
Published: May 2021

Ovarian cancer is a fatal gynecological cancer because of a lack of early diagnosis, which often relapses as chemoresistant. Trichodermin, a trichothecene first isolated from Trichoderma viride, is an inhibitor of eukaryotic protein synthesis. However, whether trichodermin is able to suppress ovarian cancer or not was unclear. In this study, trichodermin (0.5 µM or greater) significantly decreased the proliferation of two ovarian cancer cell lines A2780/CP70 and OVCAR-3. Normal ovarian IOSE 346 cells were much less susceptible to trichodermin than the cancer cell lines. Trichodermin predominantly inhibited ovarian cancer cells by inducing G0/G1 cell cycle arrest rather than apoptosis. Trichodermin decreased the expression of cyclin D1, CDK4, CDK2, retinoblastoma protein, Cdc25A, and c-Myc but showed little effect on the expression of p21Waf1/Cip1, p27Kip1, or p16Ink4a. c-Myc was a key target of trichodermin. Trichodermin regulated the expression of Cdc25A and its downstream proteins via c-Myc. Overexpression of c-Myc attenuated trichodermin’s anti-ovarian cancer activity. In addition, trichodermin decelerated tumor growth in BALB/c nude mice, proving its effectiveness in vivo. These findings suggested that trichodermin has the potential to contribute to the treatment of ovarian cancer.