bluuebunny/crossref_metadata_2025 huggingface dataset:
Going beyond Soil Conservation with the Use of Cover Crops in Mediterranean Sloping Olive Orchards
Authors: Arias-Giraldo Luis F. , Guzmán Díaz Gema , Montes-Borrego Miguel , Gramaje David , Gómez José A. , Landa Blanca B.
Published: June 2021

Among the agricultural practices promoted by the Common Agricultural Policy to increase soil functions, the use of cover crops is a recommended tool to improve the sustainability of Mediter-ranean woody crops such as olive orchards. However, there is a broad range of cover crop ty-pologies in relation to its implementation, control and species composition. In that sense, the in-fluence of different plant species on soil quality indicators in olive orchards remains unknown yet. This study describes the effects of four treatments based on the implementation of different ground covers (CC-NAT, CC-GRA and CC-MIX) and conventional tillage (TILL) on soil erosion, soil physicochemical and biological properties, and soil microbial communities after 8 years of cover crop establishment. Our results have demonstrated that the presence of a temporary cover crop (CC), compared to a soil under tillage (TILL), can reduce soil losses and maintain good soil physicochemical properties and modify greatly the structure and diversity of soil bacterial com-munities and its functioning. The presence of a homogeneous CC of gramineous (Lolium rigidum or Lolilum multiflorum) (CC-GR) for 8 years significantly increased the functional properties of the soil as compared to TILL; although the most significant change was a modification on the bacte-rial community composition that was clearly different from the rest of treatments. On the other hand, the use of a mixture of plant species (CC-MIX) as a CC for only two years although did not modify greatly the structure and diversity of soil bacterial communities compared to the TILL soil, induced significant changes on the functional properties of the soil, and reverted those properties to a level similar to that of an undisturbed soil that had maintained a natural cover of spontaneous vegetation for decades (CC-NAT).
River Basin Management Planning in the Republic of Ireland: Past, Present and the Future
Authors: Antwi Sarpong Hammond , Linnane Suzanne , Getty David , Rolston Alec
Published: June 2021

The River Basin Management Plan (RBMP) is an essential component of the European Union Water Framework Directive that details an integrated approach required to protect, improve and sustainably manage water resources. RBMP were intended to be produced for the periods 2009-2015, 2016-2021 and 2022-2027. However, after two years of delays in the development processes, the Republic of Ireland produced its first RBMP in 2010. The second RBMP cycle was also implemented in 2018 and is expected to run until the end of 2021 to give way to the third RBMP, whose consultation processes have been ongoing since December 2019. This paper contributes to the forthcoming RBMP by assessing stakeholders’ perspectives on the second RBMP through a desk-based review and by conducting interviews with nine institutions (14 interviewees). The qualitatively analysed interviews reveal a broad spectrum of actors associated with water management and governance in the Republic of Ireland through a three-tier governance structure that has been delivered (with amendment) through the first two RBMPs. Organisations such as the An Fóram Uisce|The Water Forum, the Environmental Protection Agency, the Local Authority Waters, and the Agricultural Sustainability Support and Advisory Programme have responsibilities designated in the RBMPs to deliver improved water quality, integrated catchment management, community engagement and awareness-raising. Trust has also been building up among these organisations and other agencies in the water sector. Despite these responsibilities and progress, the interviews identified communication lapses, ineffective collaboration and coordination among stakeholders and late implementation to be hampering the successful delivery of the second RBMP, in addition to significant pressures acting on water bodies from agricultural activities and urban wastewater treatment. Towards the third RBMP, the paper concludes that optimised water sector finance, enhanced and well-resourced communications, and improved stakeholder collaboration are needed to foster effective and efficient water services delivery and quality. More so, given the cross-cutting impact of the Sustainable Development Goals on water resources and the interconnected relations among the goals, the paper further recommends the integration of the SDGs in the various plans of actions and a co-benefits approach to derive the triple benefits from biodiversity, climate change initiatives and water quality measures.
Current Status of Glucocorticoid Usage in Solid Organ Transplantation
Authors: Dashti-Khavidaki Simin , Saidi Reza , Lu Hong
Published: June 2021

Glucocorticoids (GCs) have been the mainstay of immunosuppressive therapy in solid organ transplantation (SOT) for decades due to their potent effects on the innate immunity and tissue protective effects. But, some SOT centers are reluctant to administer GCs for long-time due to the various side effects. This review summarizes advantages and disadvantages of GCs in SOT. PubMed and Scopus databases were searched from 2011 to April 2021 using search syntaxes cover “transplantation” and “glucocorticoids”.GCs are used in transplant recipients, transplant donors, and organ perfusate solution to improve transplant outcomes. In SOT recipients GCs are administered as induction and maintenance immunosuppressive therapy. GCs are also the cornerstone to treat acute anti-body- and T-cell-mediated rejections. Addition of GCs to organ perfusate solution and pretreatment of transplant donors with GCs are recommended by some guidelines and protocols to reduce ischemia-reperfusion injury peri-transplant. GCs with low bioavailability and high potency for GC receptors such as budesonide, nanoparticle-mediated targeted delivery of GCs to specific organs, and combination use of dexamethasone with inducers of immune-regulatory cells are new methods of GC usage in SOT patients to reduce side effects or induce immune-tolerance instead of immunosuppression. Various side effects on different non-targeted organs/tissues such as bone, cardiovascular, neuromuscular, skin, and gastrointestinal tract have been noted for GCs. There are also potential drug-drug interactions for GCs in SOT patients.
Analysis of Students' Critical Thinking Abilities Using The PDEODE Strategy in Terms of Cognitive Style Through Online Learning
Authors: Wulandari Tabitha Sri Harteti
Published: June 2021

The  existence  of the  Covid-19   pandemic  in  2020  resulted  in  learning  being carried  out on-line.  However, critical  thinking  skills are still  honed in  the learning process. The  purpose  of this  study  was  to  obtain  a description of the  critical  thinking  skills  of students  of Mathematics  Education   2019,  PGRI  Ronggolawe   Tuban  University  in  the Environmental Knowledge  course  using the PDEODE  strategy on the Reflective cognitive style  and   Impulsive  cognitive   style.  This  type   of  research   is  descriptive  exploratory research, Data collection  techniques  used MFFf (Matching  Familiar  Figures  Test  (MFFT) and  critical  thinking   ability  tests.  The  research  subjects  were  12  students.  The  results showed  that:  1)  There were 5  students  with  a reflective cognitive style and 7 students  with an 9pulsive cognitive  style.  2) The average results of critical thinking  skills for all aspects of critical thinking  components  in the reflective cognitive  style group are:  40%  for high category    20%  for  moderate  category    40%  for  low  category   while  in  the  impulsive cognitive  style group: 28.6%  for high fJ.tegory   28.6%  for  medium  category,  and 42.8% for  low  category.  The conclusion   is  that the PDEODE  strategy can  be applied  in online learning  to empower  critical  thinking  ski! ls  in  terms of reflective  and impulsive cognitive styles.
ICT and Economic Growth Nexus: Case of Central Asian Countries
Authors: Shodiev Tursun , Turayey Bakhodir , Shodiyev Kamoliddin
Published: June 2021

The Government of Uzbekistan declared the year of 2020 as “The Year of Science, Education and Development of the Digital Economy” and is implementing the State Program, aiming at to liberalize the economy, improve market related incentives, encourage private enterprises, to reduce the role of the public sector by introducing ICT and Internet, developing digital economy. In order to understand the causal relationship between ICT investment and economic growth researchers have exert many effort in the world. The results are different: in developed countries the impact of ICT on economic growth is more powerful than in developing countries. This paper aims at finding and measuring causality between Economic growth and ICT development in emerging economies of Central Asian Countries by using panel data over  the period of  19 years  from 2000 – 2018. The research findings revealed that inflation, trade openness, final consumption expenditure and unemployment impact significantly on GDP per capita in Central Asian countries.  The econometric analysis showed  that ICT affects to GDP per capita positively and significantly: one percent increase in ICT contributes to GDP per capita 0.1669 percent (fixed broadband subscriptions) and 0.2218 percent (internet usage).Thus we concluded that information and communication technology together with economic indicators are key part of economic development in Central Asian countries. Reduction of inflation and unemployment allow expanding businesses, to create new job places in the digital economy.
Model of Application of Technology to Increase Income in Micro Business Clover Stick in The Face of Covid19 Pandemic Era
Authors: Rizqiawan Hendrik , Novianto Iful , Subaderi Subaderi
Published: June 2021

The Covid19 pandemic has caused complicated problems for many entrepreneurs, including partners who are micro-entrepreneurs. The Semanggi Stick micro business, which is run by a group of women in Lakarsantri Village, Surabaya City, has been severely affected by the Covid19 pandemic. Even in the first few months of the pandemic outbreak, their businesses did not operate. The clover sticks they produce are not the main choice that must be purchased for communities around the partner’s location. This is possible because so far partners have only marketed their products around their area, partners have not taken advantage of the availability of digital technology in marketing. In addition, partners have been carrying out the production process using conventional and simple equipment. This was considered ineffective and resulted in some partner members choosing other activities that were more productive. With the right technology application model, both in the production and marketing processes, partners will experience an increase in sales. Before the pandemic, the sales generated by partners was at 500 thousand to 1 million per month, after using this technology application model partners can get a sales of more than 2 million Rupiah in one month.
Trace Elements and REY in the Muschelkalk Limestones of the Opole Silesia in Poland
Authors: Stanienda-Pilecki Katarzyna Jadwiga
Published: June 2021

The results of researches of the selected trace elements: Ti, Sr, Ba, Zn, and also Cr, Ni, Cu, Zr, Mo, Pb, Rb, Mn, Na, K, P, Y and REE (REY) content were presented in this article. The elements were measured in the carbonate minerals of Muschelkalk (Middle Triassic) limestones of the Opole Silesia in Poland, using two methods: ICP MS spectrometry and X-ray fluorescence. These methods are characterized by very high precision and sensitivity of measurements. The results of researches show that the content of analyzed trace elements varies in from value below 1 ppm up to some hundreds ppm. However, the highest contents were measured for strontium and barium, elements characteristic for aragonite carbonate phase which is transformed such as high-Mg calcite into low magnesium calcite during diagenesis. So as Sr and Ba indicate the presence of aragonite in the primary carbonate material. The other trace elements probably form substitutions in clay or carbonate minerals. Some of trace elements such as Zn, Pb, Cu, Mo, Ni may also be associated with sulfide minerals and Ti, Cr, Mn, with oxides. Some measured REY elements- Ce, Nd, Sm, Gd, Dy, Er and Y are found in the rocks in very small quantities. So their content is really very low. It varies in from value below 1 ppm up to 6 ppm. REY usually substitute Ca ions in calcite.
Research on EEG Features in Different Emotional States
Authors: Wang Xiaotian , Wang Zuo , Guo Jiawei , Pang Chunying , Liu Jikui
Published: June 2021

In order to improve the detection and treatment of neurological diseases effectively, it is a significant means to analysis EEG features. In this study, extrovert and stable persons were selected as the subjects according to the Eysenck Personality Questionnaire. Then set the subjects’ EEG signals in a quiet state with eyes closed as a reference group. Four types of pure music were selected as stimulus materials to induce four different kinds of emotions: pleasure, sadness, irritability, and fear. During the period, evoked EEG signals was acquired. Then, some signal processing methods were used to de-noise for EEG and separate EOG artifacts from EEG signals. Finally, EEG signals’ features in time domain, frequency domain and time-frequency domain were extracted, especially the method which combined Hilbert transform based on EMD with information entropy to calculate EEG signals’ Hilbert spectrum entropy for four emotional states. The results showed that EEG signals’ features in different emotional states changed with gender, brain and mood objectively, all differences mainly reflected in time domain features, frequency domain features and time-frequency domain features. All the results reveal that EEG signals’ variation characteristics in the process of auditory stimulation, and can be an adjustment basis for detection and treatment of neurological diseases.
Prognostic and Immunological Characterization of NSD3 Evaluated through an Integrative Pan-Cancer Analysis
Authors: Li Sha , Liu Yaqiong , Yao Chaoling , Xu Anji , Zeng Xiaoling , Ge Yuxin , Sheng Xiaowu , Zhang Hailin , Zhou Xiao , Long Ying
Published: June 2021

Background: Nuclear receptor binding SET domain protein-3 (NSD3) has been reported to be a crucial regulator of carcinogenesis as a histone lysine methyltransferase in multiple cancer types. However, the underlying mechanisms have not been clearly delineated. Therefore, we aimed to investigate the expression pattern, prognostic value, and potential function of NSD3 in 33 types of human cancer. Methods: The potential roles of NSD3 were explored using datasets from The Cancer Genome Atlas (TCGA) pan-cancer dataset and an array of bioinformatics methods, including analyses of the relationship between NSD3 expression and prognosis, tumor mutational burden (TMB), microsatellite instability (MSI), DNA amplification, and immune cell inﬁltration across 33 cancer types. Results: Many types of cancers are characterized according to the dysregulation of NSD3, which is associated with the pathological stage of cancer. Patients in our study with higher NDS3 levels, which were attributed to NSD3 copy number amplification, always experienced shorter survival periods. Additionally, NSD3 expression was associated with TMB and MSI in 10 different cancer types. The top five cancers whose NSD3 expression correlated with immune scores were further analyzed. The levels of immune-cell infiltration differed significantly between high and low NSD3-expressing samples in each of the five cancer types. Functional enrichment of the NSD3 co-expressed genes indicated a role for NSD3 in the regulation of immune responses and tumorigenesis. Conclusions: Our study revealed that NSD3 can function as a prognostic marker in various cancers due to its role in tumorigenesis and tumor immunity.
Effect of Season and Climate on in-hospital Mortality and Length of Stay for Patients With Type A Aortic Dissection
Authors: Luo Zeng-Rong , Lin Zhi-Qin , Chen Liang-wan , Qiu Han-Fan
Published: June 2021

Objective: To investigated the effects of seasonal and climatic changes on in-hospital mortality and length of stay (LOS) for postoperative patients with type A acute aortic dissection (AAD). Methods: The clinical data of 404 patients diagnosed with type A AAD in our hospital and the relevant meteorological data were retrospectively collected and analyzed from January 2016 to December 2019. Results: The multivariate unconditional logistic regression analysis showed that admission in autumn (OR=4.027, 95% CI=1.023-17.301) and coronary heart disease (odds ratio OR=7.669, 95% CI=1.20-48.689) were increased risk factors for postoperative in-hospital mortality in patients with type A AAD; admission in autumn (95% CI=2.719-7.921, P=0.041) and hypertension (95% CI=1.192-5.106, P=0.035) for type A AAD patients were increased risk factors for LOS. Conclusion: Patients with admission in autumn or coronary heart disease appeared to increasing effects on postoperative in-hospital mortality for type A AAD. Patients with admission in autumn or hypertension seemed to be associated with longer LOS.
Development of Ketoprofen-p-Aminobenzoic Acid Co-Crystal: Formulation, Characterization, Optimization and Evaluation
Authors: Bhatia Meenakshi , Kumar Ashwani , Kumar Vikas , Devi Sunita
Published: June 2021

Co-crystal is a promising class of solids that may provide options for improved properties. In the present study, ketoprofen- p-aminobenzoic acid (KP-PABA) co-crystal were prepared to sought enhanced solubility and dissolution rate of drug. KP-PABA co-crystal were prepared by solvent evaporation technique employing central composite experimental design, selecting independent variables as concentration of drug and PABA whereas dependent variables were assumed to be solubility and % drug release. The optimized batch as suggested by the experimental design was characterized by FTIR, DSC, XRD, SEM and NMR studies and further, evaluated for in-vitro and in-vivo anti-inflammatory and analgesic activities. The solubility and % drug release of different batches of co-crystal was found to be between 34.20-60.11 µg/ml and 68.11–93.45%, respectively. Co-crystal containing ketoprofen and PABA in molar ratio (1:1) was found to be optimized formulation batch. Physical characterization by X-ray diffraction spectra and differential scanning calorimetric studies confirms the crystallinity of prepared co-crystal. The half maximal inhibitory concentration (IC50) values for in-vitro anti-inflammatory activity comes out to be 34.04 µM for ketoprofen and 4.373µM for optimized formulation, exhibiting almost 8-fold amplification indicating higher anti-inflammatory effect of optimized batch as compared to drug ketoprofen. The results of in-vivo anti-inflammatory activity carried out by rat paw edema method revealed that the optimized batch of co-crystal preparation provided a significant % inhibition in paw volume in contrast to standard drug in wistar rats. In this case, a crystalline molecular complex of drug Ketoprofen, that demonstrate poor aqueous solubility, with p-aminobenzoic acid was recognized that further set out an improvement in solubility and also in anti-inflammatory activity of the drug in wistar rats.
Association Between The Triglyceride-Glucose (TyG) Index and Increased Blood Pressure in Normotensive Subjects: A Population-Based Study
Authors: Lee Dong-Hwa , Park Jong Eun , Kim So Young , Jeon Hyun Jeong , Park Jong-Hyock
Published: June 2021

Insulin resistance (IR) is an important contributor to the development of hypertension (HTN), and the triglyceride-glucose (TyG) index has been proposed as a simple, reliable marker of IR. This study investigated the association between the TyG index and blood pressure (BP) elevation in a large general population without a history of related diseases. The study enrolled 15,826 adults from the 2016–2019 Korea National Health and Nutrition Examination Survey (KNHANES). Participants were classified into quartiles based on the TyG index and BP was categorized as normal BP, elevated BP, pre-HTN, and HTN. The associations of the TyG index with BP categories were assessed using multivariate multinomial logistic regression models with normal BP as the reference group. The mean systolic/diastolic BP and prevalence of HTN increased with the TyG index. The continuous TyG index had a strong dose-response relationship with increased odds of elevated BP, pre-HTN, and HTN. Compared with the lowest TyG index quartile, the highest TyG index quartile was significantly associated with higher odds of having elevated BP (OR, 1.52; 95% CI, 1.23–1.87), pre-HTN (OR, 2.18; 95% CI, 1.91–2.48), and HTN (OR, 4.14; 95% CI, 3.40–5.02). Our study suggests that the TyG index is an early predictor of the risk of HTN.
Fatty Dihydropyridines With Anti-Hypertensive and Cardioprotective Potential During Ischemia and Reperfusion
Authors: Santa-Helena eduarda , Ribeiro Joaquim de Paula , Gioda Carolina Rosa , Cabrera Diego da Costa , D’Oca Marcelo G. Montes , Nery Luiz Eduardo Maia , Gonçalves Carla Amorim Neves
Published: June 2021

In this study, three fatty dihydropyridines, were tested for their anti-hypertensive and cardioprotective properties. Dihydropyridines 2c, 8c, and 9a contain the oleic chain and the nitro unit, the oleic chain and the chlorine unit, and the palmitic chain and the chlorine unit, respectively. For the experiments, animals were treated with N(ω)-nitro-L-arginine methyl ester to induce hypertension and after treated with the new dihydropyridine compounds and the standard drug nifedipine. Then, the heart was removed and subjected to global ischemia and reperfusion. Analyses of cardiac parameters were performed to monitor cardiac functionality; lactate dehydrogenase values were quantified in perfusates. After ischemia and reperfusion were performed, analyses to check the oxidative status and lipid damage. The results of the present study suggest that the new fatty DHPs have anti-hypertensive effects offering protection against ischemia to the heart of rats, accomplished by increasing antioxidants that defend and prevent the decline in cardiac function.
Characteristic and Interplay of Esophageal Microbiota in Esophageal Squamous Cell Carcinoma
Authors: Lin Zheng , Rao Wenqing , Xiang Zhisheng , Zeng Qiaoyan , Liu Shuang , Yu Kaili , Zhou Jinsong , Wang Jianwen , Chen Weilin , Chen Yuanmei , Peng Xiane , Hu Zhijian
Published: June 2021

Background: Esophageal squamous cell carcinoma(ESCC) is severe cancer in the world. The role of esophageal microbiota for ESCC is still uncertain. In the current study, 120 paired tissues from ESCC patients were collected, and 16s rRNA sequencing was performed to explore the esophageal microbiota. Results: The present investigation shows that the diversity and composition of the microbiota in ESCC cancerous tissues and para-cancerous tissues is significantly different, this variation between subjects beta diversity mainly explained by regions and sampling seasons. Species R.Mucilaginosa, P.Endodontalis, unclassified species in genus Leptotrichia, genus Phyllobacterium, and genus Sphingomonas were enriched in cancerous tissue. On the other hand, class Bacilli, N.Subflava, H.Pylori, A.Parahaemolyticus, A.Rhizosphaerae, unclassified species in genus Campylobacter and genus Haemophilus were increased in para-cancerous tissue. Compared with the co-occurrence network in cancerous tissue, a denser and more complex association network was formed in para-cancerous tissue. Moreover, the above differential taxa also participated in both co-occurrence network but played quite different roles. Finally, the functional association analyses revealed the altered signaling pathways in ESCCs were correlated to esophageal microbiota. Conclusion: Compared with para-cancerous tissues, microbiota in cancerous tissues showed significant differences in diversity and composition. The alterations in microbial co-occurrence network and functional pathways in ESCC tissues may be involved in carcinogenesis and the maintenance of local microenvironment for ESCC. These discoveries of the esophageal microbiota for ESCC patients may contribute to the etiology for ESCC prevention, diagnosis, early intervention, and treatment.
Effects of Sintering Behaviors on Dimensional Accuracy, Surface Quality, and Mechanical Properties of Stereolithography-printed 3Y-ZrO2 Ceramics
Authors: Zhang Cheng , Jiang Zhaoliang , Zhao Li , Guo Weiwei , Zhang Chengpeng
Published: June 2021

Sintering process is essential to acquire the final components by stereolithography (SLA), which is a promising additive manufacturing technology for the fabrication of complex, custom-designed dental implants. 3Y-ZrO2 ceramics at different sintering behaviors in air atmosphere were successfully obtained in this study. Firstly, the curing properties of homemade pastes were studied, and the penetration depth and critical exposure of the pastes were calculated as 17.2 μm and 4.80 mJ/cm2, respectively. The green ceramic parts were performed at 154 mW laser power and 6000 mm/s scanning speed. Then, the dimensional accuracy, surface quality, and mechanical properties of 3Y-ZrO2 ceramics were investigated. The shrinkages of length, width, and height were 26%~27 %, 30%~31 %, and 27%~33 % in sintered ceramics, respectively. The Ra values of XOY, YOZ, and XOZ surfaces showed an anisotropic feature, and they were smallest as 0.52 μm, 2.40 μm, and 2.46 μm, respectively. Meanwhile, the mechanical properties presented a similar trend that they grew first and then dropped at various sintering behaviors. The optimal parameters were 1500 ℃, 60 min, and 4 ℃/min, and the maximum relative density of 96.18 %, Vickers hardness of 12.45 GPa, and fracture toughness of 6.35 MPa·m1/2 were achieved. Finally, the X-ray diffraction (XRD) and energy-dispersive spectroscopy (EDS) analysis demonstrated that no change was observed in crystal transformation and phase composition, and the organic was completely removed in sintered ceramics. This research is expected to provide a technical guide for the fabrication of ceramics for dental implants using SLA technique.
Construction of a Pseudogene‐associated ceRNA Network and Identification of Prognostic Pseudogene Biomarkers for Colorectal Cancer
Authors: Li Zhuoqi , Zhou Jing , Gu Liankun , Zhang Baozhen
Published: June 2021

Colorectal cancer (CRC) is one of the most common and deadly malignant carcinomas. Many long noncoding RNAs (lncRNA) have been reported to play an important role in the tumorigenesis of CRC by interacting with miRNAs and influencing the expression of some mRNAs through a competing endogenous RNA (ceRNA) network. Pseudogenes are one kind of lncRNA and can act as RNA sponges for miRNAs and regulate gene expression via ceRNA networks, but there are few studies about pseudogenes in CRC. In this study, total of 31 differentially expressed (DE) pseudogenes, 17 DE miRNAs and 152 DE mRNAs were identified by analyzing the expression profiles of colon adenocarcinoma (COAD) obtained from The Cancer Genome Atlas (TCGA). And a ceRNA network was constructed based on these RNAs. Kaplan–Meier analysis showed that 7 pseudogenes, 4 miRNAs and 30 mRNAs were significantly associated with overall survival. Then multivariate Cox regression analysis on the ceRNA-related DE pseudogenes was performed and a 5-pseudogene signature with the greatest prognostic value for CRC was identified. What’s more, the results were validated by the Gene Expression Omnibus (GEO) database, and quantitative real‐time PCR (qRT‐PCR) in 113 pairs of CRC tissues. In conclusion, this study provides a pseudogene-associated ceRNA network and 7 prognostic pseudogene biomarkers, and a 5-pseudogene prognostic risk signature that may be useful to predict the survival of CRC patients.
Suspicion of Frasier's syndrome in the nephrology unit of the Internal Medicine department of the HUEH: Case study and review of the literature.
Authors: PAUL Axler JEAN , LOUIS Dieuguens , DESRAVINES Ansly Jefferson , JEAN Raema Mimrod , BAPTISTE Alfadler JEAN , BUTEAU Jean Henold , ANDRE Wislet
Published: June 2021

ObjectiveFrasier syndrome is a rare genetic nephropathy characterized by the presence of progressive glomerulopathy with proteinuria associated with male pseudo hermaphroditism. This case study described a picture of a young boy where the clinical suspicion context reminded the Frasier Syndrome. To our knowledge, this case is the first described in Haiti.Case studyThis is a 19 years old young phenotypically male, born with a genital anomaly, was seen on referral at the nephrology/dialysis unit of the internal medicine department of HUEH for evaluation and follow-up. Insidious progression of symptoms had occurred over 3 years. Over three months of outpatient follow-up, he had four sets of renal labs drawn, and all showed impaired renal function. At the ultrasound a bilateral cryptorchidism is described in the inguinal, and presence of functional ovaries with follicles of variable size scattered in the parenchyma. So, in the light of these anamnestic, clinical and paraclinical findings we concluded to the diagnosis of end-stage renal failure by progressive glomerulopathy in a context of Frasier's syndrome.ConclusionWith any clinical picture consisting of genital anomalies at birth, renal symptomatology during childhood and the diagnosis of renal failure during adolescence, rare genetic nephropathies, such as Frasier syndrome must be considered.
Artemether Targets Raptor-Induced Actin Polymerization and Suppresses Migration of Fibroblast-like Synoviocytes in Rheumatoid Arthritis
Authors: Ma Jian-Da , Jing Jun , Wang Jun-Wei , Zhang Xue-Pei , Li Qian-Hua , Mo Ying-Qian , Lin Jian-Zi , Luo Man-Li , Dai Lie
Published: June 2021

Background: Fibroblast-like synoviocytes (FLS) in rheumatoid arthritis (RA) may cause articular damage as a result of its aggressive features including direct adhesion and invasion of surface cartilage in joints. Artemether (ART), one of the artemisinin derivatives with antimalarial properties, showed inhibitory effect on inflammation and destruction of joints in collagen-induced arthritis rats, which might be applied in RA treatment. However, whether ART has effects on the aggressive properties of human RA-FLS remains unexplored. Methods: Synovium was obtained from patients with active RA (n=18) and FLS were isolated in vitro. RA-FLS were subjected to cell migration, invasion assays, live-cell imaging analysis and Rho GTPase activation assay after ART treatment. To identify the therapeutic target of ART, key signaling molecules of PI3K/Akt, AMPK, MAPK, NF-κB and mTOR pathways from RA-FLS were examined by Western Blot after ART treatment. Raptor was knockdown or overexpressed by siRNA or lentivirus transfection to reveal its role on regulating the aggressive properties of RA-FLS.Results: ART treatment significantly suppressed the transwell migration and invasion of synovial FLS from RA patients. Time-lapse microscopy revealed that ART treatment reduced random migration velocity of RA-FLS, as well as the directional persistence. ART also impaired the formation of filopodia and lamellipodia in RA-FLS. Further mechanism investigation showed that ART reduced the protein level of Raptor, a critical component of the mTOR pathway, and its downstream target 4E-BP1. It also inhibited the activation of Rho GTPases and the expression of actin binding proteins, including Profilin 1 and p-Cofilin. Raptor overexpression could reverse the anti-migration and anti-invasion effects of ART on RA-FLS as well as the suppression of Rho GTPases activation and the expression of actin binding proteins. Conclusion: ART can inhibit migration of RA-FLS by blocking Raptor-induced actin polymerization. ART might be a potential agent targeting FLS in RA treatment.
Mitochondrial Membrane Potential Influences Aβ Production and Amyloid Precursor Protein localization
Authors: Wilkins Heather , Troutwine Benjamin , Menta Blaise , Manley Sharon , Strope Taylor , Lysaker Colton , Swerdlow Russell
Published: June 2021

Beta amyloid (Aβ), which derives from the amyloid precursor protein (APP), forms plaques and serves as a fluid biomarker in Alzheimer’s disease (AD). How Aβ forms from APP is known, but questions relating to APP and Aβ biology remain unanswered. AD patients show mitochondrial dysfunction and an Aβ/ APP/ mitochondria relationship exists. Here, we considered how mitochondrial biology may impact APP and Aβ biology. We showed that mitochondrial depolarization routes APP to, while hyperpolarization routes APP away from, the organelle. Mitochondrial APP and cell Aβ secretion inversely correlate, as cells with more mitochondrial APP secrete less Aβ, and cells with less mitochondrial APP secrete more Aβ. Overall, our findings indicate mitochondrial function alters APP localization and suggest enhanced mitochondrial activity or factors associated with enhanced mitochondrial activity promote Aβ secretion while depressed mitochondrial activity or factors associated with depressed mitochondrial activity minimize Aβ secretion. Our data complement other studies that indicate a mitochondrial, APP, and Aβ nexus, and could help explain why cerebrospinal fluid Aβ is lower in those with AD. Our data further suggest Aβ secretion could serve as a biomarker of cell or tissue mitochondrial function.
Deciphering the interactions of SARS-CoV-2 proteins with human ion channels using machine learning-based method
Authors: Munjal Nupur S. , Sapra Dikscha , Goyal Abhishek , Parthasarathi K.T. Shreya , Pandey Akhilesh , Banerjee Manidipa , Sharma Jyoti
Published: June 2021

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the worldwide COVID-19 pandemic which began in 2019. It has a high transmission rate and pathogenicity leading to health emergencies and economic crisis. Recent studies pertaining to the understanding of the molecular pathogenesis of SARS-CoV-2 infection exhibited the indispensable role of ion channels in viral infection inside the host. Moreover, machine learning-based algorithms are providing higher accuracy for host-SARS-CoV-2 protein-protein interactions (PPIs). In this study, predictions of PPIs of SARS-CoV-2 proteins with human ion channels (HICs) were performed using PPI-MetaGO algorithm. The PPIs were predicted with 82.71% accuracy, 84.09% precision, 84.09% sensitivity, 0.89 AUC-ROC, 65.17% MCC score and 84.09% F1 score. Thereafter, PPI networks of SARS-CoV-2 proteins with HICs were generated. Furthermore, biological pathway analysis of HICs interacting with SARS-CoV-2 proteins showed the involvement of six pathways, namely inflammatory mediator regulation of TRP channels, insulin secretion, renin secretion, gap junction, taste transduction and apelin signaling pathway. The inositol 1,4,5-trisphosphate receptor 1 (ITPR1) and transient receptor potential cation channel subfamily A member 1 (TRPA1) were identified as potential target proteins. Various FDA approved drugs interacting with ITPR1 and TRPA1 are also available. It is anticipated that targeting ITPR1 and TRPA1 may provide a better therapeutic management of infection caused by SARS-CoV-2. The study also reinforces the drug repurposing approach for the development of host directed antiviral drugs.
THE ART OF NOVELLA BY IHARA SAIKAKU (TRADITIONS AND NATIONAL SPECIFICITY)
Authors:   PhD Student, Department of foreign Eastern countries literature and comparative literature, Tashkent State University of Oriental Studies, Republic of Uzbekistan., Bakhtiyorjon Qizi Qosimova Gulnorakhon
Published: June 2021

Literature, as any type of panhuman activity, has its own canons and patterns that have been mastered and expanded by the classic writers of all nations of the worldover the centuries.In particular, Japanese literature is characterized by reliance on traditions, the active use of historical experience of previous periods literature and redefinition of the past, as well as an original and innovative point of view on reality.It is known that in the East the role of traditions has always been very important. Social behavior, the need to adhere to national traditions in the formation of the consciousness of each individual. Undoubtedly, this also applies to the cultural sphere of Japanese life, especially the work of writers. Direct references to past sources in the creative process were considered as important criteria in assessing the value of the work, and for a long time it was an indicator of the authorâ€™s level and extensive knowledge. The paper covers the role of literature traditions, the principles of interpretations classical Japanese and Chinese literary sources in the works of a talented representative of Japanese literature of the seventeenthcentury Ihara Saikaku. For this purpose, a selection of the interpreted works of the author and their analysis with a number of classical primary sources of Japanese and Chinese literature has been made. Through the analysis, the principles of redefinition, an innovative interpretation of examples of Japanese and Chinese literature of the past, as well as shifts in the system of artistic representations of that time have been revealed.
ISTHMOCELE UTERIN : A PROPOS DE QUATRE CAS
Authors: Bellajdel Ibtissam , Taheri Hafsa , Saadi Hanane , Mimouni Ahmed
Published: June 2021

Introduction: Isthmocele is a dehiscence at the uterine caesarean scar sitting at the anterior uterine wall opposite the isthmus. The objective of the study is to define uterine isthmoceles and its diagnostic and therapeutic modalities. Material And Methods: Through a retrospective study on a series of4 patients who presented a post caesarean isthmocel taken in charge at the gynecology department of the CHU MOHAMED VI of Oujda during the period from December 1, 2016 to December 31, 2020. Results: The patients have an average age of 40 years, multiparous at least cesareanized once.The most frequent reason for consultation was metrorrhagia. In our patients, the physical examination was unremarkable. Pelvic ultrasound and hysterosonography allowed the diagnosis of isthmocele, 2 patients were treated by laparoscopic surgery, two patients by surgical hysteroscopy. The evolution was favorable with disappearance of the symptoms and improvement of the fertility, indeed we note the occurrence of a spontaneous miscarriage then an evolutive pregnancy in the patient treated by hysteroscopy. Conclusion: Although its clinical picture is not very specific, uterine isthmocele is a new entity that should be thought of in front of a scarred uterus. There is no consensus yet, but its treatment is based on laparoscopic detection of the isthmic defect and its correction. Hysteroscopy can also be proposed as a diagnostic and therapeutic modality.
EFFECTS OF DRY NEEDLING ON CALF MUSCLE IN CASE OF MYOFASCIAL TRIGGER POINT WITH MILD RESTRICTION OF KNEE JOINT MOVEMENT: A CASE STUDY
Authors:   Assistant Professor, Dept. of Physiotherapy, UIHS, CSJM University, Kanpur., Shukla Neha , Kumar Chandrashekhar ,   Assistant Professor, Dept. of Physiotherapy, UIHS, CSJM University, Kanpur.
Published: June 2021

Background: Trigger point on calf muscle is a common musculoskeletal condition it is usually felt as an intense pain when the concerned extremity is used to put on weight.The upper medial and upper lateral trigger points refer pain locally to the back of the knee causing slight end range restrictions. it is the most common musculoskeletal complaint presenting to physicaltherapy. Objective: Reduction of calf pain and to improve the end range of motion of the knee joint. Thus, helps in enhancing the functional activities. Methods: The study was done on one patient aiming to reduce calf pain and mild end range restriction of knee joint movements, we used dry needling technique for treatmentpurpose Result: We found reduction in the calf muscle pain and improvement in end range of movement of the knee joint after 2 sessions of dry needling. Case Representation: one patient came to us having pain on calf muscle, local tenderness and end range restriction of the knee joint and patient was having no history of trauma patient was undergoing for analgesic medication.
RELATIONSHIP BETWEEN NATIONAL AND GENERAL VALUES IN HUMAN VIRTUES
Authors:   Andijan Machine Building Institute Department of Humanities Candidate of Philosophical Sciences, Associate Professor., Aripova Solizhonovna Zulfiyakhon
Published: June 2021

In this article, the eastern part of the individuals problems, the glorification and analysis of human dignity, the formation of a persons spiritual maturity, the formation of human behavior, the influence of the sublime values â€‹â€‹of religion, national and universal values â€‹â€‹on human values. From this point of view, it is important to instill in the hearts and minds of our children a love for the Motherland, respect for national and universal values, to warn and protect them from all calamities and influences that are alien to us, and to bring up our children in this spirit.
THE DEVELOPMENT OF THE NATIONAL SYSTEM OF EDUCATION AND UPBRINGING IS THE BASIS FOR CREATING THE FOUNDATION OF THE THIRD RENAISSANCE
Authors:   Associate Professor of the Department Methodology of Socio-Economic Sciences of the Andijan Regional Territorial Center for Retraining and Advanced Training of Public Education Workers, Candidate of Philosophy., Odilov Kodirjon
Published: June 2021

The article examines the policy implemented in Uzbekistan for the development of the national system of education and upbringing in the conditions of the formation of the foundations of the third Renaissance and the attitude of society to the personality of the teacher and the opportunities created by the conditions for young people.
A SYSTEMATIC REVIEW OF METHODS OF EMOTION RECOGNITION BY FACIAL EXPRESSIONS
Authors: Abdulwakil Auma Muazu , Manzi Eric , Aminu Jibril
Published: June 2021

Facial recognition is integral and essential in todays society, and the recognition of emotions based on facial expressions is already becoming more usual. This paper analytically provides an overview of the databases of video data of facial expressions and several approaches to recognizing emotions by facial expressions by including the three main image analysis stages, which are pre-processing, feature extraction, and classification. The paper presents approaches based on deep learning using deep neural networks and traditional means to recognizing human emotions based on visual facial features. The current results of some existing algorithms are presented. When reviewing scientific and technical literature, the focus was mainly on sources containing theoretical and research information of the methods under consideration and comparing traditional techniques and methods based on deep neural networks supported by experimental research. An analysis of scientific and technical literature describing methods and algorithms for analyzing and recognizing facial expressions and world scientific research results has shown that traditional methods of classifying facial expressions are inferior in speed and accuracy to artificial neural networks. This reviews main contributions provide a general understanding of modern approaches to facial expression recognition, which will allow new researchers to understand the main components and trends in facial expression recognition. A comparison of world scientific research results has shown that the combination of traditional approaches and approaches based on deep neural networks show better classification accuracy. However, the best classification methods are artificial neural networks.
LIPOSTRUCTURE: EXPERIENCE OF THE DEPARTMENT OF PLASTIC SURGERY OF THE MOHAMMED VI UNIVERSITY TEACHING HOSPITAL OF MARRAKESH
Authors: Mohamed Elmehdi Sahibi , Benlaasel Oumnia Ait , Imane Yafi , El Mehdi Mahrouch , Mehdi Elgueouatri , Ismail Zineddine , Driss Elamrani Moulay , Banchamkha Yassine
Published: June 2021

This is a descriptive retrospective study of 42 cases of patients who underwent the lipostructure procedure at the Department of Plastic Surgery of Mohammed VI Teaching Hospital of Marrakesh, over a period of 6 years, from January 2012 to December 2017. It aims to report our experience, and to review the procedure, applications, and outcomes of lipostructure. A total of 61 procedures were performed. The average age of our patients was 28.78 years. A female predominance was noted (86%). The main indications were: burn sequelae (33%), trauma sequelae (17%), infection sequelae (10%) and facial rejuvenation (10%). In terms of local conditions, most of our patients suffered from skin scars (61.9%), atrophy (14.28%), wrinkles (9.52%), facial asymmetries (7.14%), and nasal deformities (7.14%). The samples was mainly harvested from the abdomen (42%), followed by the trochanteric region (saddle bags) in 38% of cases. 67.21% of the samples were harvested from a single donor site. The average volume collected was 74.52 ml. All the samples were centrifuged by the Regenlab system. 52% of the lipostructure procedures were performed on the face, with an average injected volume of 23.25ml. 42.62% of the lipostructures were associated with an injection of PRP, and 6.55% with a facelift.
PHYSICAL ACTIVITIES IN THE CORONA ERA ARE A BOON
Authors:   Masters in Physical Education, Department of Physical Education, HPU, Summer Hill Shimla-171005(H.P.)., Kumar Akshay , Kumar Amar ,   M.Phil. Research Scholar, Center for Deendayal Upadhyay Studies, CUHP, Sapta Sindhu Parisar Dehra kangra-177101(H.P.).
Published: June 2021

The journey from forest to land and from soil to house has made a huge impact on the work efficiency and physical routine of man. In the modern era, the mechanical work has made the physical work of the human more relaxed. Due to which their physical defense system has been adversely affected. And man has been surrounded by many incurable diseases. The most severe attack on this plight of humans was done by the corona virus, a disease that emerged in 2019 China. Due to which millions of human beings lost their lives. And that person is becoming the easiest sufferer of this disease, their physical disease immune system is weak. Or they do not do physical work, exercise, yoga etc. to the person. Whether physical activities be it labor, exercise, yoga, the physical disease of man keeps the immune system healthy.