bluuebunny/crossref_metadata_2025 huggingface dataset:
Nursing strikes among infants and its affecting factors in Rafsanjan city
Authors: Jalali Fatemeh ,   Clinical Research Development Unit, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran,   Clinical Research Development Unit, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran,   Clinical Research Development Unit, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran,   Clinical Research Development Unit, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran,   Clinical Research Development Unit, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran,   Department of Pediatrics, Ali-Ibn Abi-Talib Hospital, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran, Kamiab Zahra ,   Department of Family Medicine, Ali-Ibn Abi-Talib Hospital, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran, Khademalhosseini Morteza ,   Department of Pathology, Ali-Ibn Abi-Talib Hospital, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran, Daeizadeh Fatemeh , Bazmandegan Gholamreza ,   Department of Family Medicine, Ali-Ibn Abi-Talib Hospital, School of Medicine, Rafsanjan University of Medical Sciences, Rafsanjan, Iran,   * Corresponding Author: Gholamreza Bazmandegan, Clinical Research Development Unit, Ali-Ibn Abi-Talib Hospital, Rafsanjan University of Medical Sciences, Rafsanjan, Iran. Phone: +98 9133913032, Fax: +98 3434280185. Email: bkhrbster@gmail.com
Published: April 2021

The infant’s refusal to breastfeed can be a stressful and concerning matter for a mother. This study aimed to investigate the frequency and factors leading to nursing strikes in Rafsanjan city. This descriptive study was performed on infants who had been referred to the pediatrician’s office with a complaint of a nursing strike. The research sample included 70 infants, and all the required data, including the causes of the nursing strike and the demographic information of the mother and the infant, were collected using a checklist. The Statistical Package for the Social Sciences (SPSS) software version 20 was used to analyze the data. The percentage was used to express qualitative indices, and the mean and standard deviation were used to express quantitative indices. The results showed that the most common factors contributing to the infants’ breast refusal were playfulness and distraction (50%) and recent vaccinations in the last 12 days (48.6%). Besides, the most common maternal factors affecting breast refusal were level of education (67.1%), recent acute stress (41.4%), and inadequate milk production (35.7%). The results of the present study showed that playfulness and distraction of the baby, recent vaccination, use of a pacifier, level of education and recent stress of the mother, breastfeeding program, and insufficient milk production are the most common reasons for nursing strikes.
The role of novel poly (ADP-ribose) inhibitors in the treatment of locally advanced and metastatic Her-2/neu negative breast cancer with inherited germline BRCA1/2 mutations. A review of the literature
Authors: Pop Lucian ,   Department of Obstetrics and Gynecology, Alessandrescu-Rusescu National Institute of Mother and Child Health, Bucharest, Romania, Suciu Ioan ,   Department of General Surgery, Floreasca Emergency Hospital, Bucharest, Romania,   Department of Obstetrics and Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Ionescu Olivia ,   Department of Obstetrics and Gynecology, South Nurnberg Hospital, Nurnberg, Germany, Bacalbasa Nicolae ,   Department of General Surgery, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, Ionescu Paris ,   Department of Obstetrics and Gynecology, Ovidius University, Constanta, Romania
Published: April 2021

The use of the PARP inhibitors (PARPi) in the treatment of breast cancer (BC) with germine mutations has evolved over the years, and further research has been done in order to broaden the horizon of this treatment strategy. Therefore the aim of this paper is to review the efficiency of PARPi in the treatment of BRCA 1/2-mutated locally advanced and metastatic Her-2/net negative BC mentioning their side effects, mechanism of resistance and future directions. Inhibition of PARP transforms single-strand breaks into double-strand breaks (DBS), the accumulation of the latter causing cell death (cell apoptosis). The Olympia AD phase III trial demonstrated a statistically significant progression-free survival rate (PFS) when using the PARPi olaparib in metastatic BC with germline BRCA1/2 mutations without any benefit of the overall survival rate. PARPi therapy is associated with acceptable responsive rates and progression-free survival rates in locally advanced and metastatic BRCA1/2 associated BC through mechanisms that enhance and increase the sensitivity to chemotherapeutic or target agents as they induce a synthetic lethality and cell apoptosis. The side effects are not significant, the most adverse effects being related to the hematological and gastrointestinal systems. Olaparib is currently approved in the first-line treatment of BRCA1/2 mutated Her-2/neu negative metastatic BC at an oral dose of 300 mg twice daily, while Talazoparib represents a category one recommendation in locally advanced and metastatic Her-2/neu negative BC in women with central nervous system metastases.
The epidemiology of myasthenia gravis
Authors: Bubuioc Ana-Maria ,   Department of Neurology, Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova,   Department of Neurology, Nicolae Testemitanu State University of Medicine and Pharmacy Chisinau, the Republic of Moldova, Kudebayeva Aigerim ,   Department of Neurology, Kazakh Medical University of Continuing Education, Almaty, Kazakhstan, Turuspekova Saule ,   Department of Nervous Diseases with course of Neurosurgery, Asfendiyarov Kazakh National Medical University, Almaty, Kazakhstan, Lisnic Vitalie ,   Vitalie Lisnic, MD, PhD, Professor, Department of Neurology, Nicolae Testemitanu State University of Medicine and Pharmacy, 2 Korolenko str., MD – 2028, Chisinau, the Republic of Moldova. Fax: +373-022737200. Phone: +373-79456641. E-mail: vitalie.lisnic@usmf.md, Leone Maurizio Angelo ,   Neurology Unit, Fondazione IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy
Published: April 2021

Neuromuscular junction (NMJ) disorders include several dysfunctions that ultimately lead to muscle weakness. Myasthenia gravis (MG) is the most prevalent NMJ disorder with a highly polymorphic clinical presentation and many different faces. Being an autoimmune disease, MG correlates with the presence of detectable antibodies directed against the acetylcholine receptor, muscle-specific kinase, lipoprotein-related protein 4, agrin, titin, and ryanodine in the postsynaptic membrane at the NMJ. MG has become a prototype serving to understand both autoimmunity and the function of the NMJ better. The aim of this review is to synthesize some of the epidemiological data available. Epidemiological data regarding MG are important for postulating hypotheses regarding its etiology and facilitating the description of MG subtypes. Thus, adequate documentation through broad databases is essential. The incidence and prevalence of MG reported around the globe have been rising steadily and consistently over the past decades. Ethnic aspects, gender-related differences, and environmental risk factors have been described, implying that these might contribute to a specific phenotype, further suggesting that MG may be considered an umbrella term that covers several clinical entities.
INCREASING THE EFFICIENCY OF THE POWER SUPPLY SYSTEMS OF THE OIL AND GAS INDUSRTY
Authors:   Yuri Gagarin State Technical University of Saratov, Saratov, Russia, Kulbyakina А. V. , Ozerov N. А. ,   Yuri Gagarin State Technical University of Saratov, Saratov, Russia, Batrakov P. А. ,   Omsk State Technical University, Omsk, Russia, Savelyeva А. I. ,   Yuri Gagarin State Technical University of Saratov, Saratov, Russia, Munin А. P. ,   Yuri Gagarin State Technical University of Saratov, Saratov, Russia
Published: April 2021

Предприятия нефтегазового комплекса являются серьезным источником воздействия на окружающую среду. В статье рассмотрены основные вредные вещества, образующиеся в результате технологических процессов, протекающих на предприятиях отрасли и оказывающие негативное воздействие на атмосферу, гидросферу и литосферу. Определены наиболее значимые источники загрязняющих веществ. Приведены наиболее перспективные подходы, отмеченные отечественными и зарубежными авторами для создания экологически чистых, малоотходных технологических производств с комплексным использованием всех компонентов сырья, энергетических ресурсов, производственных отходов с обеспечение требуемых технологических режимов. Авторами разработана и предложена схема установки энергообеспечения с комплексной утилизацией отходов предприятий нефтегазовой отрасли направленная на комбинирование технологических процессов термической утилизации производственных отходов (горючих газов, стоков) с процессами газификации и выработки энергоресурсов (электрической, тепловой энергии, синтез-газа, водоснабжения), снижение удельного потребления топливного газа на выработку энергоресурсов и утилизацию отходов, повышение экологической безопасности и надежности объекта.
COMPARATIVE ANALYSIS OF AERODYNAMIC CHARACTERISTICS OF METHANE STEAM CONVERSION CATALYSTS
Authors:   Saratov State Technical University named after Yuri Gagarin, Saratov, Russia, Mrakin А. N. , Afanasyeva O. V. ,   Peter the Great St. Petersburg Polytechnic University, St. Petersburg, Russia, Vdovenko I. A. ,   Saratov State Technical University named after Yuri Gagarin, Saratov, Russia, Ageev M. A. ,   Saratov State Technical University named after Yuri Gagarin, Saratov, Russia, Selivanov A. A. ,   Saratov State Technical University named after Yuri Gagarin, Saratov, Russia, Batrakov P. A. ,   Omsk State Technical University, Omsk, Russia
Published: April 2021

Рассматриваются основные результаты оценки аэродинамического сопротивления слоя катализаторной засыпки процессов паровой конверсии углеводородов, а также установок, реализующих процесс термохимической регенерации теплоты отходящих газов. Представлены эмпирические зависимости различных авторов для определения коэффициента сопротивления. Установлено что соотношения (10-12) наиболее адекватно описывают гидродинамическую картину протекающих процессов, поскольку удельное сопротивление, вычисленное по ним находится в диапазоне 25-26 кПа/м, что соотноситься с показателями промышленных агрегатов, эксплуатируемых в схожих гидродинамических режимах (сопротивление составляет 18-31 кПа/м).
FORMATION OF REQUIREMENTS TO THE LABORATORY EXPERIMENTAL UNIT UNDER CONDITION OF CONTINUATION OF RESEARCHES OF PROCESSES OF HEAT AND MASS TRANSFER ON A MODEL EXPERIMENTAL UNIT
Authors:   Omsk State Technical University, Omsk, Russia, Trushlyakov V. I. , Lesnyak I. Yu. ,   Omsk State Technical University, Omsk, Russia, Urbansky V. A. ,   Omsk State Technical University, Omsk, Russia
Published: April 2021

Рассматриваются теоретические результаты моделирований вакуумного процесса испарения модельной жидкости в замкнутом объёме, проведённых для экспериментальной лабораторной установке (ЭЛУ) и экспериментальной макетной установке (ЭМУ), отличающиеся размерами, граничными и начальными условиями. Параметры ЭМУ определены на основе теории подобия процессам, протекающим в баке ступени ракеты-носителя в поле малых перегрузок, а параметры ЭЛУ выбраны из условия возможности существующего лабораторного оборудования. На примере процесса испарения жидкости при вакуумных воздействиях для ЭЛУ и ЭМУ, полученных путём использования программного комплекса ANSYS Fluent, рассчитаны корреляционные функции параметров процессов (масса и температура), показывающие степень близости процессов. В ходе проведения численных экспериментов варьировалась производительность вакуумного насоса для обеспечения равенства критерия Нуссельта для ЭЛУ и ЭМУ.
METHOD OF AUTOMATIC CLASSIFICATION OF THE SPEAKER'S EMOTIONAL STATE BY VOICE
Authors:   JSC «Civil Aviation Academy», Almaty, Republic of Kazakhstan, Koshekov К. Т. , Kobenko V. Yu. ,   Omsk State Technical University, Omsk, Russia, Anayatova Р. К. ,   JSC «Civil Aviation Academy», Almaty, Republic of Kazakhstan, Savostin А. А. ,   Manash Kozybayev North Kazakhstan University, Petropavlovsk, Republic of Kazakhstan, Koshekov A. K. ,   JSC «Civil Aviation Academy», Almaty, Republic of Kazakhstan
Published: April 2021

В данной статье рассматривается проблема разработки эффективного метода автоматической классификации эмоций авиационного персонала (диктора) по голосу. Для этого решается задача по созданию дикторонезависимого алгоритма, способного выполнять многоклассовую классификацию семи эмоциональных состояний человека (радость, страх, гнев, печаль, отвращение, удивление и нейтральное состояние) на основании набора из 48 информативных признаков. Данные признаки формируются из цифровой записи речевого сигнала путем расчета мел-частотных кепстральных коэффициентов и частоты основного тона для отдельных фреймов звукозаписи. Повышение информативности и снижение размерности для мел-частотных кепстральных коэффициентов выполняется за счет их обработки при помощи глубокой сверточной нейронной сети. Модель классификатора реализована при помощи логистической регрессии, которая обучалась по указанным информативным признакам на базе записей эмоционально окрашенных образцов английской речи. В результате обучения на тестовой выборке доля правильных ответов распознавания составляет accuracy = 0,96. Предложенное в работе решение может быть использовано для улучшения человеко-машинных интерфейсов, а также в области авиационных перевозок, медицине, маркетинге и пр.
A STUDY OF CONNECTORS AND FEED LINES DE-EMBEDDING TECHNIQUESFOR PCB MICROWAVE COMPONENTS S PARAMETERS MEASUREMENTS UP TO 50 GHZ
Authors:   «50ohm Lab», Tomsk state university of control system and radioelectronics (TUSUR), Tomsk, Russia, Salnikov A. S. , Dobush I. M. ,   «50ohm Lab», Tomsk state university of control system and radioelectronics (TUSUR), Tomsk, Russia, Bilevich D. V. ,   «50ohm Lab», Tomsk state university of control system and radioelectronics (TUSUR), Tomsk, Russia, Popov A. A. ,   «50ohm Lab», Tomsk state university of control system and radioelectronics (TUSUR), Tomsk, Russia, Kalentyev A. A. ,   «50ohm Lab», Tomsk state university of control system and radioelectronics (TUSUR), Tomsk, Russia, Goryainov A. E. ,   «50ohm Lab», Tomsk state university of control system and radioelectronics (TUSUR), Tomsk, Russia
Published: April 2021

Рассмотрены методы исключения влияния разъемов и подводящих линий из результатов измерений СВЧ-компонентов на печатных платах в частотном диапазоне до 50 ГГц. Проведено сравнение между широко используемым методом Multiline Thru-Reflect-Line (MTRL) и перспективным методом 2xThru. Показано, что методы дают схожие результаты, однако, для 2xThru требуется всего одна тестовая структура в отличии от MTRL, для которого используется шесть тестовых структур. Различие между параметрами испытуемого устройства по коэффициенту передачи составляют не более 0,35 дБ по модулю и 1,5° по фазе, по коэффициенту отражения - не более 0,08 по модулю и не более 10° по фазе в большинстве частотных точек.
SMOOTHING THE SURFACE ROUGHNESS OF ALUMINUM NITRIDE FILMS OBTAINED BY MAGNETRON SPUTTERING
Authors:   Institute of Radiophysics and Physical Electronics OSC SB RAS Omsk, Russia, Baranova L. V. ,   Dostoevsky Omsk State University, Omsk, Russia, Strunin V. I. ,   Institute of Radiophysics and Physical Electronics OSC SB RAS Omsk, Russia; Dostoevsky Omsk State University, Omsk, Russia; Omsk Scientific-Research Institute of Instrument Engineering, Omsk, Russia
Published: April 2021

При получении пленок нитрида алюминия, применяемых в радиоэлектронных устройствах на объемных (ОАВ) и поверхностных (ПАВ) акустических волнах, таких как резонаторы, фильтры, датчики, методом магнетронного распыления возникает проблема из-за большой шероховатости поверхности пленок. В данной работе исследуется возможность повышения качества поверхности пленок нитрида алюминия, за счет сглаживания шероховатости ее поверхности при облучении пучком кластерных ионов аргона.
Fikcja a manipulacja i postprawda
Authors: Fidos Łukasz
Published: April 2021

Autor podejmuje próbę rozwinięcia rozumienia głośnego w ostatnich czasach pojęcia postprawda ‒ jako „odnoszącego się do sytuacji lub oznaczającego sytuację, w której obiektywne fakty mają mniejszy wpływ na kształtowanie opinii publicznej niż odwoływanie się do jej emocji i osobistych przekonań”. W artykule pojęcie to przedstawione jest w świetle analizy przede wszystkim pojęcia fikcja, które uważane jest wprawdzie za główną cechę literatury (pięknej), lecz jest także elementem innych form wypowiedzi, na przykład unormowań prawnych ‒ jako fikcja prawna. Postprawda pretenduje do roli prawdy historycznej współczesnych czasów, takiej jak faktografia w dziele naukowym, toteż istotną konstatacją jest uwaga o nieostrych granicach poznawczych pomiędzy fikcją literacką, opartą na danych historycznych a tekstem historycznym naukowym. Znaczenie ma również obserwowane zapotrzebowanie odbiorców fikcji na utożsamiania jej treści z rzeczywistością, na emocjonalną potrzebę identyfikacji zmyśleń z faktami. Fikcja jako specyficzny twór językowy zawiera wiele elementów umożliwiających elastyczne wykorzystanie jej treści do różnych celów, jak udawanie, naśladowanie, zdania o działaniu, które nie przynosi żadnego skutku. Toteż nierzadko fikcja ‒ niejako udając rzeczywistość ‒ wprowadza do kultury kłamstwo „z pretensją do istnienia”. Nad możliwościami wykorzystania fikcji, manipulacji czy nawet kłamstwa w określonych praktycznych celach rozprawiano już w starożytnej Grecji, postprawda nie wykorzystuje zatem specyficznych narzędzi stworzonych przez jej twórców. Autor upatruje różnic pomiędzy postprawdą a manipulacjami minionych czasów w warunkach społecznych i kulturowych funkcjonowania tych pojęć, konstatując przy tym, że w minionych czasach władza wykorzystywała kłamstwo w celu manipulowania podwładnymi, postprawda zaś stanowi już reakcję podwładnych na kłamstwa i manipulacje władzy.
Dylematy i wyzwania współczesnej wiedzy profilaktycznej
Authors: Skubisz Jolanta
Published: April 2021

Szkoła musi wiedzieć, jak w obliczu kryzysu (upadku) współczesnego modelu kształcenia kształtować nowy proces tworzenia wiedzy w celu poprawy jakości czy też wręcz zmiany całego procesu wychowawczo-profilaktycznego. W dużej mierze to współczesne technologie komunikacyjne kształtują zachowania i oczekiwania młodzieży, a także umiejętności związane z dostępem, opanowaniem, używaniem, tworzeniem i komunikowaniem informacji. Właściwe używanie na zajęciach, nie tylko lekcyjnych, technologii informacyjno-komunikacyjnych inspiruje uczniów do myślenia, tworzenia i rozwiązywania problemów w nowy, niestandardowy i innowacyjny sposób (outside the box). Istotna staje się kwestia, jak wykorzystywać wiedzę o zagrożeniach szkolnych w działaniach niosących pomoc uczniom zagrożonym? Gdzie w tym wirtualnym świecie ulokować wiedzę profilaktyczną? W jakiej relacji do dylematu nowych wyzwań technologiczno-informacyjnych sytuuje się e-wiedza profilaktyczna? Obecnie w przestrzeni szkolnej występują dwa modele profilaktyki: tradycyjny model działań profilaktycznych i wykorzystujący elektroniczne środki dydaktyczne model e-learningowej profilaktyki. Jest to zatem swoista hybrydowość profilaktyczna.
Możliwości wykorzystania repozytoriów internetowych typu Cloud w dydaktyce
Authors: Siemianowski Liwiusz
Published: April 2021

W pracy przedstawiono przegląd wybranych repozytoriów danych w technologii tzw. danych Chmury – Data Cloud. Zarysowano ich powstanie i rozwój ze wskazaniem podstawowych zalet i możliwości, szczególnie współdzielenia zasobów pamięci oraz mocy przetwarzania. Wyszczególniono i scharakteryzowano szereg popularnych serwisów Cloud, w tym: OneDrive, Google Drive, Dropbox. Podkreślono przydatność internetowych repozytoriów danych dla wspomagania prowadzenia dydaktyki. Wskazano na możliwość uzupełnienia technicznego platform zdalnego kształcenia oraz użyteczność Data Cloud w przechowywaniu i udostępnianiu prac o dużym zapotrzebowaniu na pamięć masową.
Zastosowanie robotów AGV w intralogistyce
Authors: Płaczek Ewa , Osieczko Kornelia
Published: April 2021

Problematyka logistyki wewnętrznej w odniesieniu do zastosowania robotów jest stosunkowo rzadko podejmowana w literaturze polskiej. Szukając sposobów optymalizacji, najczęściej porusza się temat narzędzi i metod szczupłego zarządzania (z ang. Lean Management). Jedną z możliwości usprawnienia logistyki wewnętrznej (intralogistyki) jest zastosowanie robotów transportowych. Celem artykułu jest przedstawienie dostępnych na polskim rynku rozwiązań z zakresu optymalizacji wewnętrznego przepływu towarów w przemyśle. Wiąże się to z wykorzystaniem dostępnych technologii i automatyzacją procesów poprzez zastosowanie autonomicznych robotów AGV. Artykuł ma charakter opisowy, prezentujący dostępne rozwiązania.
PERSEPSI MAHASISWA PADA PELAKSANAAN KURIKULUM PROGRAM MAGISTER PENDIDIKAN SOSIOLOGI
Authors: Marodama Eskiel
Published: April 2021

The purpose of this study was to determine students' perceptions of the implementation of the curriculum, be it about the curriculum, implementation, and evaluation curriculum learning process. The method used is the quantitative method and the form of research is the survey. The results of this study indicate that (1) the perception of students towards higher education curriculum that is organized by the Master Program in Sociology of Education FKIP UNTAN for 21.78% of the total score of 25, showed that the average student agrees to the curriculum of higher education conducted, ( 2) students 'perceptions of the organization of higher education curriculum that is organized by the Master Program in Sociology of Education FKIP UNTAN for 21.44% of the total score of 25, showed that the average student agrees to the curriculum of higher education conducted, (3) students' perceptions evaluation of higher education learning process organized by the Master Program Sociology Education FKIP UNTAN for 88.4% of the total score of 86, showed that the average student agrees to the evaluation of higher education learning process is implemented.
Tunable Band Gaps in MUV-10(M): A Family of Photoredox-Active MOFs with Earth-Abundant Open Metal Sites
Authors: Fabrizio Kevin , Lazarou Konstantinos , Payne Lillian , Twight Liam , Hendon Christopher H. , Brozek Carl K.
Published: April 2021

Titanium-based metal—organic frameworks (Ti-MOFs) attract intense research attention because they can store charges in the form of Ti3+ and they serve as photosensitizers for co-catalysts through heterogeneous photoredox reactions at the MOF-liquid interface. Both charge storage and charge transfer depend on redox potentials of the MOF and the molecular substrate, but the factors controlling these energetic aspects are not well understood. Additionally, photocatalysis involving Ti-MOFs relies on co-catalysts rather than the intrinsic Ti reactivity in part because Ti-MOFs with open metal sites are rare. Here, we report that the class of Ti-MOFs known as MUV-10 can be synthetically modified to include a range of redox-inactive ions with flexible coordination environments that control the energies of the photoactive orbitals. Lewis acidic cations installed in the MOF cluster (Cd, Sr , and Ba ) or introduced to the pores (H, Li, Na, K) tune the electronic structure and band gaps of the MOFs. Through use of optical redox indicators, we report the first direct measurement of the Fermi levels (redox potentials) of photoexcited MOFs in situ. Taken together, these results explain the ability of Ti-MOFs to store charges and provide design principles for achieving heterogeneous photoredox chemistry with electrostatic control.
Possibilities of combination lipid-lowering therapy in a patient with very high cardiovascular risk (сlinical case)
Authors:   Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia, Sedykh Daria Yu. , Fedorova Natalia V. ,   Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia, Kashtalap Vasily V. ,   Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia
Published: April 2021

The article demonstrates the possibility of prescribing an effective and safe lipid-lowering combination of the most tolerated doses of statins in combination with ezetimibe, using the example of a patient with severe lipid metabolism disorders in the post-infarction period. It has been shown that in real clinical practice, patients with acute coronary syndrome and persisting high LDL values are quite common, despite of the prescription of statins. These patients need closer follow-up and wider use of combined lipid-lowering therapy by adding ezetimibe to maximally tolerated doses of statins. Current clinical guidelines allow this to be done when patients fail to achieve target LDL values (>1.4 mmol/L) with statins monotherapy. This approach is effective and safe, which is illustrated by this hereditary clinical case. In routine clinical practice mandatory lipids control is required 4–6 weeks after patient’s discharge from the hospital for acute coronary syndrome. If the target lipids values were not achieved with the maximum dosage of statins, a mandatory using the combination therapy with ezetimibe is required. Keywords: myocardial infarction, dyslipidemia, improved prognosis, statins, ezetimibe For citation: Sedykh DYu, Fedorova NV, Kashtalap VV. Possibilities of combination lipid-lowering therapy in a patient with very high cardiovascular risk (сlinical case). Consilium Medicum. 2021; 23 (1): 70–73. DOI: 10.26442/20751753.2021.1.200604
Resistant arterial hypertension
Authors:   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, Rodionov Anton V. , Yudin Ivan G. ,   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, Fomin Viktor V. ,   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia
Published: April 2021

The review provides modern data on the examination and treatment tactics of patients with resistant arterial hypertension (RAH). The prevalence of RAH is about 10–15%, with a significant proportion of pseudo-resistance cases associated with low adherence to therapy, inaccurate blood pressure measurement technique, and increased arterial stiffness in the elderly. In patients with RAH, it is necessary to exclude secondary hypertension, of which drug hypertension associated with the use of nonsteroidal anti-inflammatory drugs, nasal sympathomimetics, oral contraceptives, as well as those caused by obstructive sleep apnea syndrome or primary hyperaldosteronism are prevalent. Secondary hypertension is often asymptomatic, therefore, additional examination is required for patients without the classic signs of these diseases. Pharmacotherapy of RAH includes a high-dose combination of antihypertensive drugs. In the first instance, first-line drugs (the renin-angiotensin system blockers, calcium antagonists, thiazide diuretics) should be combined with mineralocorticoid receptor antagonists, which have a good evidence base (PATHWAY-2, ReHOT studies), and then other reserve drugs. The study of interventional methods for the treatment of RAH continues. To date, the effectiveness of renal denervation has been proven. The study of the method of carotid baroreflex amplification continues. Keywords: arterial hypertension, resistant arterial hypertension, secondary arterial hypertension, antihypertensive therapy, renal denervation For citation: Rodionov AV, Yudin IG, Fomin VV. Resistant arterial hypertension. Consilium Medicum. 2021; 23 (1): 28–31. DOI: 10.26442/20751753.2021.1.200697
Gouty (urate) nephropathy
Authors:   Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia, Fomin Viktor V.
Published: April 2021

Clinical variants of kidney damage in gout including asymptomatic disorders of uric acid metabolism are discussed. The risk factor for hyperuricemia and associated kidney damage, clinical variants of gouty nephropathy and approaches to its treatment are presented. Keywords: gout, urate nephropathy, hyperuricemia, uric acid For citation: Fomin VV. Gouty (urate) nephropathy. Consilium Medicum. 2021; 23 (1): 11–14. DOI: 10.26442/20751753.2021.1.200709
Experience of using a fixed combination of ramipril and indapamide in clinical practice
Authors:   Burdenko Voronezh State Medical University, Voronezh, Russia, Kochetkovа Irina V.
Published: April 2021

Relevance. Arterial hypertension is one of the most common cardiovascular diseases in the adult population, but much has already been achieved in its treatment. The advantages of combination therapy, according to the clinical recommendations "Arterial Hypertension in Adults" in 2020, are as follows: an increase in the degree of blood pressure reduction is much stronger than an increase in the dose of a single drug; the possibility of physiological and pharmacological synergy between drugs of different classes, which may underlie a more pronounced reduction in blood pressure and better tolerability of treatment; suppression of the opposite mechanisms of increasing blood pressure. Aim. Aim of the study was to study the effect of the antihypertensive drug – Konsilar-D24 on the clinical picture, HRV data, and hemodynamic parameters in patients with stage II hypertension of the 2nd degree. Materials and methods. 40 patients with stage II AH and grade 2 AH were examined. During the outpatient examination, all patients were evaluated for HRV, SCAD, SMAD, ECHO-KG, ECG, GFR, laboratory and biochemical examination (UAC, OAM, blood bch-creatinine, urea, glucose, ASAT, ALAT), and the SF-36 quality of life questionnaire. Results. An increase in SVVR, a decrease in blood pressure, and an increase in the quality of life of the patient. Discussion: Konsilar-D24 is an effective antihypertensive agent for grade 2 hypertension in the complex treatment of stage II hypertension. Against the background of therapy, there is a persistent achievement of target figures, an increase in vagal tone. There is a metabolic neutrality of the drug, as well as nephro and cardioprotective effects. Keywords: arterial hypertension, ramipril, indapamide For citation: Kochetkovа I.V. Experience of using a fixed combination of ramipril and indapamide in clinical practice. Consilium Medicum. 2021; 23 (1): 103–108. DOI: 10.26442/20751753.2021.1.200759
Abstracts from the Eleventh European Students’ Conference of the Charité
Authors:   European Students Conference of the Charité
Published: April 2021

N/A
On Ecology of Eurythrophic Wood-Destroying Fungi Fomes fomentarius (L.) Fr. and Fomitopsis pinicola (Sw.) P. Karst. in the City of Krasnoyarsk and Surroundings (Russia, East Siberia)
Authors:   Siberian Federal University, Kryuchkova O. E. , Yaskova S. G. ,   Siberian Federal University, Tropina E. F. ,   National park “Krasnoyarsk Stolby”, Golovnina N. N. ,   Siberian Federal University
Published: April 2021

This paper is devoted to the review of the environmental and trophic characteristic features of eurytrophic wood-destroying fungi in Krasnoyarsk and its nearest suburbs in habitat conditions with various anthropogenic loads. The research covered forest stand within the green areas of the city (including islands of the Yenisei River), forest areas at the outskirts of the city and in «Stolby» state nature reserve. The research included two species of tinder fungus widely spread in the Northern hemisphere: Fomes fomentarius (L.) Fr. (confined to various hardwoods, mostly birch) and Fomitopsis pinicola (Sw.) P. Karst. (confined to trees of various species). Both species of fungi are facultative parasites. The research showed that these species of fungi use quite a restricted set of host substrates showing a pretty narrow range of trophic preferences, despite the presence of numerous species of trees suitable for them at the surveyed area. F. fomentarius uses birch, poplar and aspen as a substrate within the researched area. It is very rarely found at other wood species. The trophic range of the highly eurytrophic species F. pinicola is represented here mostly by a few coniferous species, such as pine, fir and spruce tree. This fungus is present at birch trees and aspen much more rarely. These species of tinder fungi were not found at other wood species of the surveyed area. F. fomentarius is very often found at birches in the areas with minimal anthropogenic load (in «Stolby» nature reserve) and becomes less numerous with the increasing manthropogenic load. The situation is the contrary with poplar: F. fomentarius is rarely found at poplar in the areas with low or medium anthropogenic load, but often destroys poplar wood in the areas with the increased anthropogenic load (within the green space of urban areas). Moreover, F. fomentarius is often found in parklands, rather than along the roadside lanes. F. pinicola is typical for ecosystems with low anthropogenic load and prefers coniferous wood species. It is mostly found in ecosystems of “Stolby” natural reserve, mainly on fir and pine species.
Effect of the Nutrient Medium Composition on the Growth and Antifungal Activity of Bacillus Bacteria Used as the Basis of Experimental Biofungicides for the Green Plant Protection System
Authors:   Federal Research Center of Biological Plant Protection, Homyak A. I. , Zhevnova N. A. ,   Federal Research Center of Biological Plant Protection, Asaturova A. M. ,   Federal Research Center of Biological Plant Protection
Published: April 2021

The article presents the results of the studies of the influence of the nutrient medium composition for the cultivation of Bacillus bacteria. We compared standard microbiological media and optimized nutrient medium according to criteria such as the number of colony forming units in liquid culture and antifungal activity against the test culture of F. graminearum fungus. It was noted that the number of colony forming units of LC based on the B. subtilis BZR 336g strain on the optimized medium turned out to be significantly higher than on King B media and potato-glucose medium and amounted to (8.7±0.66) x 1010 CFU/ml, for B. subtilis BZR 517 strain titer on an optimized medium was (7.2±0.42) x 1010 CFU/ml. Antifungal activity on an optimized nutrient medium for B. subtilis BZR 336g was strain 83.5%, for B. subtilis BZR 517 strain – 61.1%. We found the positive effect of experimental samples of biofungicides obtained with the help of an optimized nutrient medium on the growth and development of winter wheat plants against the background of artificial infection in a climatic chamber. The treatment of winter wheat seeds with experimental samples of biofungicides ensured biological efficiency from 35.4% to 60.8% with the efficiency of the Kinto Duo chemical standard, KS 38.9%, Fitosporin-M biological standard – 28.9%. It was noted that seed germination in the variant with biofungicide treatment based on the optimized medium was 20-30% higher than in the variants with standard media. Seed treatment with experimental samples of biofungicides obtained on various nutrient media showed a statistically significant increase in the biometric parameters of winter wheat seedlings.
Proposal for Automatic Vehicle Number Plate Recognition System in POLIMAS
Authors:   Politeknik Seberang Perai, Penang
Published: April 2021

Automatic Vehicle Number Plate Recognition (AVNPR) system is an image processing technology in computer vision which captures the image of the vehicle and recognizes its number plate. Currently, the security and management of transportation system becomes an important key in controlled place such as campus area. With an increased number of vehicles, there is a need for vehicle recognition mechanism that is effective, affordable and efficient. The objective of this paper is to propose an efficient automatic vehicle identification system by recognizing the vehicle plate number. The system will be installed at the main entrance of POLIMAS to ensure that only the authorized vehicles can automatically enter the campus area. Once the vehicle is detected by the input sensors, AVNPR system will capture the image of vehicle plate number. An image is then extracted and investigated character segmentation by using optical character recognition (OCR). The method used for detection of a plate number is by pre-processing of the image and using a combination of Sobel edge detection and Laplacian edge detection techniques. Bounding Box technique is used to find the number plate and character segmentation. For character recognition, OCR method is used by using template matching to compare the segmented image with the template. The system is sustainable as the camera will only be switched on when a car is present. The propose system successfully detects and recognizes the vehicle number plate on real images. This system can also be used for security and traffic control.
Environmental risk assessment of intensive beekeeping integrated with aquaponic system
Authors:   “Dunărea de Jos” University of Galaţi,Galati, Romania
Published: April 2021

The paper main objectives are to identify an analysis model for development of integrated aquaponics with intensive beekeeping. The socio-economic environmental impact assessment provides the opportunity to analyze the determinants of public attitude towards the use of multifunctional aquapson. In relation to the other agricultural production branches, beekeeping integrated into aquaponic systems is an environmentally friendly technology that does not use additional energy supply within the integrated production system and also recycles waste water from aquaculture through mechanical, biological filters and plant roots.
Avoidable deaths in the extreme south of Bahia: Infectious and parasitic diseases/ Óbitos evitáveis no Extremo Sul da Bahia: doenças infecciosas e parasitárias/ Muertes evitables en el extremo Sur de Bahía: enfermedades infecciosas y parasitarias
Authors: Luiza Coutinho Matos Santana Ana , Chaves Lima Guilherme , Lopes de Oliveira Gisele
Published: April 2021

Objetivo: este estudo propôs analisar as taxas de mortalidade por Doenças Infecciosas e Parasitárias do Extremo Sul da Bahia no período de 2008 a 2018. Métodos: trata-se de um estudo descritivo que considerou os dados referentes aos óbitos por “causas evitáveis” na população entre 05 a 74 anos, reduzíveis por ações adequadas de promoção à saúde, prevenção, controle e atenção às doenças de causas infecciosas, disponibilizados no Sistema de Informação sobre Mortalidade. Resultados:  entre os anos de 2008 e 2018 foram notificados 1.347 óbitos no Extremo Sul da Bahia. Foi observada prevalência de óbitos em pessoas do sexo masculino, em todos os anos, representando 61,17%; a classe notificada com nenhuma escolaridade foi a mais afetada, com 321 óbitos; o intervalo de idades em que se concentrou o maior número de óbitos foi de 30 a 44 anos, representando 35,47%. As doenças infecciosas e parasitárias com maior ocorrência de óbitos foram HIV-Aids, Tuberculose e Diarreia/Gastroenterite de origem infecciosa presumível. Conclusão: as mortes por doenças infecciosas e parasitárias possuem estreita relação com fatores socioeconômicos, bem como aos processos de crescimento populacional acelerado, falta de saneamento básico e expansão urbana.
The Effectiveness of Rosella Flowers to the Changes of Hemoglobin Levels of Third Trimester Pregnant Women in The Area of The RatuAgung Community Health Center in 2020
Authors: Mizawati Afrina , Wulandari Rifi
Published: April 2021

Anemia during pregnancy is one of the most common disorders in pregnant women in Indonesia. The Government has made efforts to overcome this problem, however, the rate of anemic mothers remains high. Rosella (Hibiscus Sabdariffa) is considered able to increase the hemoglobin levels in pregnant mothers. To analyze the effect of Rosella flower on the increase of Hemoglobin level in pregnant women receiving Fe tablet. This study was a quasy experiment with pretest-posttest control group design conducted in January 2020 in the working area of Ratu Agung Community Health Center. Thirty-two participants were selected using accidental sampling, which assigned in the experiment and control group. All samples were pregnant women in the third trimester and receiving iron tablets. Independent t-test and paired t-test were used for data analysis. The paired t-test obtained a p-value of 0.00 (<0.05), indicated that there was an increase of hemoglobin levels in both experiment and control group. The mean increase of hemoglobin levels in the control group was 0.59 gr and in the experiment group was 1.11. The hemoglobin levels in the experiment group were higher than the levels in the control group. The independent t-test obtained a p-value of 0.241 (> 0.05) indicating that there wasn't a significant difference of mean of hemoglobin levels between the control group and the treatment group. The consumption of rosella combined with Fe tablet showed a significant increase of hemoglobin levels compared of pregnant women. Therefore,
Level of Anxiety and Community Behavior in Preventing the Covid-19 Pandemic in East Java
Authors: Soâ€™emah Eka Nur , Windartik Emyk , Rahmawati Ima
Published: April 2021

Corona virus-19 (COVID) has been declared a global pandemic. The increase in cases of covid-19 can be prevented by disease prevention behavior in accordance with the protocol that has been established by the government. However, there are still many people who heed the protocol. This condition has an impact on people's anxiety, coupled with the presence of information that continues to be rolled out on social media and mass media about the development of covid-19. Anxiety is increasing with the stigma of the community about covid-19 patients. The purpose of this study was to analyze the level of anxiety and behavior of the community in preventing COVID-19 disease in East Java. The design of the study was descriptive survey. The sample in this study was people in East Java with the sampling techniques by accidental sampling techniques. The data collection used questionnaires using GAD-7. scale and behavior questionnaire according to DIRJEN control and prevention of covid-19 March 2020. The analysis of descriptive statistical test data that was percentile / percentage. The results showed that most people in East Java experience minimal anxiety and positive behavior. Minimal anxiety occured because most respondents are highly educated and already know about Covid-19, this will help solve psychological problems including anxiety. The efforts of health workers are also very much needed to always assist the community in adhering to health protocols by providing sustainable health education.
The Improvement of Reproductive Health Knowledge (Vaginal Discharge and Menstrual Pain) of Women
Authors: Wantini Nonik Ayu , Zakiya Zahrah , Styaningrum Silvia Dewi
Published: April 2021

Vaginal discharge and menstrual pain are problems that are often faced by women. Women should be able to distinguish between physiological and pathological vaginal discharge, physiological and pathological menstrual pain. Based on the results of previous studies, most women have insufficient knowledge about vaginal discharge and menstrual pain. Health education is an effort to overcome these problems. The purpose of this study was to determine reproductive health care habits, history of menstrual pain and vaginal discharge, differences in knowledge about reproductive health, especially vaginal discharge and menstrual pain before and after health education was given. This study was a quasi-experimental design with one group pre test-post test. The sample was 27 women in Setan Hamlet, Maguwoharjo, Depok, Sleman who were selected by purposive sampling. The instrument used a questionnaire. The data analysis used paired sample t-test. The results showed that 66.7% had carried out routine genetalia care, 29.6% routinely used feminine cleansing soap, 25.9% experienced menstrual pain, vaginal discharge as much as 37%. The mean knowledge before health education was 48.70 (SD 23.59), while the mean knowledge after health education was 87.59 (SD 6.84). There is a difference between knowledge about reproductive health before and after health education is given (p-value = 0.000). The conclusion is that health education increases knowledge about reproductive health.
The Effect of Sambiloto Extract on the Expression of Î² Estrogen Receptors in Ovaries and Lust Cycle in Mice Model PCOS - Insulin Resistance
Authors: Rahayu Hanis Kusumawati
Published: April 2021

Infertility was a serious problem in the reproductive period, one of the caused of infertility were common in women of childbearing age group is Polycystic Ovary Syndrome (PCOS).Sambiloto (Andrographis paniculata Nees), had been already known contain flavonoid and lactones. The purpose of this research had to determine the effect of various doses of sambiloto extract with the expression of Î² estrogen receptor and estrus cycle in the mice model of PCOS - insulin resistance. This research was an animal model experimental laboratory research with a completely randomized design (CRD).The results showed that sambiloto extract therapy in treatment group had an improvement estrus cycle compared with control group. Positive control group, almost 90% had persistent anestrus condition. In treatment group 1 and 2 in the last vagina smear obtained anestrus condition as much as 60% in diestrus and medestrus phase. Whereas treatment groups 3 all experimental animals in a estrus state by proestrus and estrus phase. Î² Estrogen receptor expression had tested by Kruskal Wallis test for overall treatment, obtained significantly different results (p â‰¤ 0.002) followed by Mann - Whitney, showed that immunoreactive cells score from highest to lowest occurred in each group Negative control (KN), P3, P2, P1 and Positive Control (KP).It could be concluded that sambiloto extract at dose 18mg/kgbb, 36mg/kgbb, and 72mg/kgbb had been given an overview of the differences expression of Î² estrogen receptor, could change the estrus cycle of female mice models of insulin resistance PCOS.