bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction and elimination of pollution in ecosystems formed by decommissioned sludge reservoirs
Authors: Chertes Konstantin L. , Bukin Aleksey A. , Bukhman Nikolai S. , Pystin Vitaliy N. , Seyanko Artem P. , Tupitsyna Olga V.
Published: July 2023

Introduction. The principles of forecasting and eliminating the consequences of pollution formed by decommissioned accumulators of heterophase municipal and industrial waste by means of high-pressure washing are proposed. The main tasks to be solved are the development of sludge accumulator assessment parameters and modelling pollution flows in geo-environments with heterogeneous filtration and rheological characteristics using the proposed prediction criteria.

Materials and methods. The prediction is based on the model of mass transfer of pollution in the geo-environment from the standpoint of the laws of the theory of filtration and electrostatics. The regularities of the theory of filtration (Darcy’s Law) form the basis for the transport of “pure” liquids (true solutions) through “ideal” porous media. The regularities of electrostatics form the basis for the mass transfer of viscous pollution flows in fragments of the geo-environment with non-uniform resistance. An industrial experiment was carried out on high-pressure flushing of the geo-environment with flocculant solutions to eliminate pollution formed by a decommissioned hazardous waste storage facility.

Results. Filtration and rheological properties of sludge and polluted geo-environment have been studied. Mathematical models of contaminated liquid filtration into the geo-environment from sludge bodies have been developed. The main dependences of the change in the filtration-rheological characteristics of the polluted geo-environment on the values of the solution injection pressure and the trajectory of the predicted radius of pollution are presented.

Conclusions. According to the results of industrial research the method of high-pressure reagent washing of rocks of aeration zone from pollution of organic and mineral nature contained in infiltrates based on liquids of various viscosities has been developed. The hydrodynamic connection between absorbing and producing wells was revealed in the conditions of experimental areas of the cleaned geo-environment. The proposed methods for forecasting and eliminating pollution can be applied in projects for the elimination of objects of accumulated environmental damage formed by inactive sludge waste storage tanks.
Efficiency of solar panels application in conditions of Leningrad region
Authors: Kartashov Mikhail A. , Ivanova Ekaterina I. , Strelets Kseniya I. , Radaev Anton E.
Published: July 2023

Introduction. Comfort in private homes remains a constant reason why more and more people prefer permanent residence in the suburbs. Energy supply and savings are becoming one of the most important reasons for turning to alternative energy sources. One of these is the use of solar panels and installations. In this paper, the efficiency of using such a method of energy supply at home is considered, the calculation of the cost and payback in the Leningrad region is given.

Materials and methods. The methods of measurements on the object and mathematical methods of estimation were used.

Results. Autonomous power supply of the house is possible only in the period from March to September, in January, February, October, November and December it is necessary to resort to using additional equipment as a generator.

Conclusions. According to the results of the study, the installation of an autonomous system for providing a low-rise construction facility with electricity on solar cells has a very long payback period when located in the Leningrad region, while an economic assessment shows that it is advisable to add up the funds spent on the installation for a long-term period rather than paying for electricity every month. Such a solution can be effective in conditions where there is no alternative to energy sources or being at a distance from a common power line, since the costs of laying the power grid will be similar to this installation without taking into account the cost of paying for electricity according to the tariff.
Main principles of the formation of organizational and technological platform for scientific and technical support of unique objects
Authors: Lapidus Azariy A. , Shevchenko Irina S.
Published: July 2023

Introduction. Scientific and technical support (STS) is a modern tool for quality and safety control when realizing unique objects of capital construction. As an independent activity, STS has a large number of directions, interactions and processes carried out in its implementation. However, along with the significant contribution of STS in the realization of unique buildings and structures, it has a number of imperfections and open issues. It is proposed to solve them by using new terminology and the method of STS organization in a single structure — the organizational and technological platform for scientific and technical support of unique objects (OTP STS).

Materials and methods. In order to form an organizational and technological platform, the STS is considered from the standpoint of systems engineering and the application of a systematic approach. The platform representation of STS activities makes it possible to structure the existing directions and interactions of STS into a single platform space. To formalize the interaction between the elements of the OTP STS, it is proposed to use the goal tree method with the decomposition of the platform objectives into levels.

Results. Identification of the main subsystems of the OTP STS: Participants, Processes, Database of works, allowed to formulate the concept of the OTP STS. In order to obtain the necessary result from the activities of the OTP STS, all its elements need to work together. The use of the goal tree method made it possible to perform a level-by-level decomposition of goals, where at the top level — the general goal of the platform, then — problems (tasks) that are the goals of the platform subsystems, at the bottom level — directions of decisions (a set of measures aimed at achieving the goals of a higher level).

Conclusions. Organizational and technological platform of scientific and technological support is a set of basic elements of STS, based on the interaction of the processes implemented by the participants of a unique construction project that occur during scientific and technical support, and the use of a database of work in order to achieve the result of STS. Achievement of objectives of platform subsystems will allow to eliminate existing shortcomings of STS activity that will positively influence not only on result of STS performance, but also on terms of organization of this process and, hence, on terms of construction project realization.
The Development of Paediatric Malay Matrix Sentence Test (PaedMalayMST) Materials through the Construction of a Paediatric Malay Corpus
Authors: Zakaria Nur 'Azzah , Jamaluddin Saiful Adli , Wan Aslynn Wan Ahmad , A. O'Beirne Greg , Zulkeflee Nur Awatif , Abd Razak Atiffah Zawani
Published: July 2023

The selection of material is important in the development of a paediatric speech perception test. Even though several studies have documented various sources of speech testing materials, using corpus was recommended to develop a Matrix Sentence Test (MST). However, as available Malay corpus was limited to written words only, this research aims to construct a Paediatric Malay corpus from a combination of written and spoken words of children in Malaysia and to develop word-based matrix (WBM) for the Paediatric Malay Matrix Sentence Test (PaedMalayMST) based on the developed corpus. The WBM replicates the Malay grammatical structure in these three categories: number, object, and adjective. Based on these criteria, the words from the developed corpus were then filtered by considering the frequency of occurrences and its phonemic distributions to be included in the WBM. As a result, a matrix of three categories with six words for each category was constructed.
Lenguas de herencia ancestral como mecanismos de resistencia: El caso del criollo limonense en Costa Rica
Authors: Vásquez Carranza Luz Marina , Schlemer Alcântara Liliane Cristine
Published: July 2023

Los procesos de colonialidad ejercidos alrededor del mundo han lesionado valores y principios de herencia ancestral, incluyendo prácticas lingüísticas, pues se han impuesto formas dominantes sobre las creencias y cosmovisiones de comunidades minoritarias. Dichosamente, luchas dadas por comunidades indígenas y afrodescendientes han constituido formas de resistencia contra esas fuerzas hegemónicas. Nos referimos al caso de la lengua criolla de base inglesa hablada por la comunidad afro-limonense en Costa Rica, el criollo limonense. Con base en datos obtenidos a través de metodologías cualitativas, encontramos que, a pesar del poder hegemónico ejercido por parte del español y del inglés sobre esta lengua vernácula y de su evidente debilitamiento, esta aún forma parte esencial de la identidad afro- limonense.
Uso da estratégia cloze na avaliação e intervenção em leitura: uma revisão sistemática de literatura
Authors: Melo Lays Santana de Bastos
Published: July 2023

O objetivo do presente artigo foi realizar uma revisão sistemática de literatura com o intuito de verificar a existência da divulgação científica a respeito do emprego da estratégia Cloze como instrumento de avaliação e de tratamento de problemas de leitura. Adotou-se como metodologia a pesquisa bibliográfica de caráter exploratório e descritivo, tendo como fontes artigos científicos publicados nas bases eletrônicas do Scielo, Lilacs e Periódicos Capes. Privilegiaram-se as publicações em Língua Portuguesa datadas a partir de 2000. A coleta de dados ocorreu no período de maio de 2012 a maio de 2014, sendo selecionados 24 artigos que atendiam aos critérios definidos. Evidenciou-se que a maioria dos artigos (95%) abordavam aspectos da avaliação utilizando a técnica Cloze, em detrimento da intervenção. Tal fato revela a necessidade de realização de pesquisas e de divulgação da contribuição da estratégia Cloze aos programas de remediação dos transtornos de leitura.
The effect of papyrus wetlands on flow regulation in a tropical river catchment
Authors: Oyarmoi Alem , Birkinshaw Stephen , Hewett Caspar J.M. , Fowler Hayley
Published: July 2023

Papyrus wetlands, native to central and eastern Africa and attaining
heights up to 5 to 6 m, occur as rooted or floating marshes in riverine
and lacustrine landscapes. This study assessed and quantified the
impacts of these papyrus wetlands on historical baseflow and quickflow,
and future flood and low flows in the Mpologoma catchment in Uganda. By
estimating the Wetland Specific Impact (metric of increase or decrease
in flow to wetland area) for a 30-year historical period and indices of
flow duration, magnitude, and frequency for the future period, it was
possible to demonstrate the role that papyrus-dominated floodplain
wetlands play in regulating river flow at the catchment scale.
Assessment over the historic period shows that wetlands strongly
attenuate quickflow while moderately enhancing baseflow. They play a
moderating role in most months, except for the first dry season (June
and July), due to the reversal of flows between wetlands and rivers that
often occurs during this period. Annual estimates show that wetlands are
four times better at regulating quickflow than baseflow. Examination of
changes at 2 and 4°C global warming levels (GWLs) indicate that wetlands
will play critical roles in mitigating flood risks, with a lesser role
in supporting low flows. Wetlands are predicted to lower future mean
flood magnitude by 5.2 and 7.8% at GWL2 and GWL4, respectively, as well
as halving the average number of flood events in a year, irrespective of
the warming level. However, the mean flood duration is expected to
increase by 77.8% (56 days) and 80.3% (49 days), respectively. This
study highlights the need for the conservation and protection of
papyrus-dominated wetlands.
A Study on Smart Agriculture Monitoring System Using Different IoT Applications
Authors: Christopher Dr.A.B.Arockia , MSivakumar * , Murrugavel Dr.A.S.Muthantha , SPriyatharsini * , Rajasekar *
Published: July 2023

Agriculture, is the predominant source of occupational or
progression in India that ranges between 75 and 80 percentage of. After
the production only based on agriculture. After the trauma and chaos of
Second World War (1950-1960) every country concentrated to improve the
agricultural farms, their production and value added agro produced.
Human and animal resources are the mainly used during that tenure for
versatile deeds of agriculture like ploughing, irrigation, weeding and
harvesting. The dogs and bounds have been used to protect the cultivated
crops and human houses.
The industrial revolution paved a new
opening in the agricultural verticals too since 1980. Machineries have
been used for all sorts of agricultural activities from ploughing to
honesty. After 2K centuries the agriculture systems are so much improved
with smart agricultural technique and internet of things. Now a days
used by various systematic approaches to improve the yield of the crops
are with multiple times improved. But the yield of agriculture foods are
poor quality and reduce the human lifetime because of modern agriculture
systems. It used so much of newly invented medicines to the crop. Our
proposed system is to concentrate the modern agriculture systems with
old agricultural methods used to improve the quality and lifetime of a
crop for producing natural foods are very useful to increase the human
lifetime. The primary goal of the proposed system is to reduce manual
labor and provide an innovative and convenient way to collect
agricultural data. Various sensors like soil moisture sensor, air
quality sensor, waterproof temperature sensor, humidity and temperature
sensor etc., collect data from the farm field and the surrounding
environment farming field. The farmers can prepare their garden/farm
fields accordingly by analyzing these data. In the recent years,
utilization of systematic approaches improves the yield of crops on
Multifood.
Strategy and exploration of identifying drug combinations for antithrombosis from Xijiao Dihuang Tang formulae as p38MAPK inhibitor
Authors: Yin Lian , Dai Yang , Zhou Gui , Chen Cui , Ping Jiang , Xia Jie , Li Guo
Published: July 2023

Background and Purpose: Combination therapy has been widely recognized
internationally, however, identifying drug combinations with synergism
is very challenging. We first proposed a strategy for identifying drug
combinations from herbs with mutual reinforcement or assistance in
traditional Chinese medicine (TCM) formulae, and verified it using the
example of Xijiao Dihuang Tang (XDT) , a classical TCM formula.
Experimental Approach: In vitro the smallest half maximal inhibitory
concentration (IC50) values of the candidate ingredients in XDT and
synergistic neuroprotective effect of the drug combinationsin were
studied in injured PC12 and BV2 cell by CCK8 and flow cytometry assay.
The p38MAPK pathway affected by the drug combinations were predicted and
validated using molecular docking method, biolayer interferometry,
western blot and immunoprecipitation assessment. Antithrombotic of the
drug combinations were evaluated in zebrafish thrombosis model in vivo.
Results Two drug combinations with a combination index value of 0.1- 0.5
were obtained, indicating strong synergy. Our results suggested that,
compared to the individual ingredients, the two drug combinations can
strengthen the synergistic neuroprotective effects and have a
significant antithrombotic effect, and not only enhanced the interaction
with on MKK3, MKK6 and p38 in the p38MAPK pathway, but also interrupted
the MKK3-p38 axis to inhibit MKK3-induced activation of p38 MAPK.
Conclusions Our study identified two synergistic drug combinations as
p38MAPK pathway inhibitors to develop antithrombotics and suggests that
provide approaches and effective means for identifying drug combinations
with synergism from the combination of herb-herb with mutual
reinforcement or assistance in TCM formulae for drug combination
development.
Congenital Dyserythropoietic Anemia Type IV with KLF1 E325K Mutation --
Authors: Massey Gita , Chesney Alden , Ravindranath Yaddanapudi
Published: July 2023

Congenital Dyserythropoietic Anemia Type IV (CDA-IV) is still an
emerging new disease with approximately 10 cases reported over the past
three decades. CDA-IV is known to be caused by a specific mutation in
exon 3 of KLF1, an erythroid transcription factor KLF1 with substitution
of glutamic acid with lysine at residue 325 (KLF1 E325K). Because of the
rarity of this disorder the presenting features are incompletely
defined; especially the non-erythroid comorbidities. Here we report a
new case, a male child, presenting with fetal hydrops and dysmorphic
external genitalia.
Epidemiology of herpes simplex virus type 2 in China: Systematic review, meta-analyses, and meta-regressions
Authors: Zheng Chunfu , Wang Yehua , Yan Xumeng , Ai Wei , Chen Rongyi , Jia Yuanxi , Fan Chengxin , Hu Siyue , Dai Yifan , Xue Huachen , Li Feifei , Zhai Jinbo , Xia Xuefeng , Tang Weiming
Published: July 2023

Background: Herpes simplex virus type 2 (HSV-2) infection is
prevalent and a significant public health problem. Understanding its
epidemiology will help assess the current HSV-2 prevention efforts and
inform future interventions in China. Methods: We followed
Cochrane and PRISMA guidelines for a systematic review and included
publications published in Chinese and English bibliographic systems
until March 18 , 2023. We synthesized
seroprevalence, sero-incidence, and proportions of HSV-2 isolated in
genital ulcer disease (GUD) and genital herpes data. We used
random-effects models for meta-analyses and conducted meta-regression to
assess the association between population characteristics and
seroprevalence. Results: Overall, 21,849 articles were
identified, and 457 publications (1,051,035 participants) were included.
A total of 429 studies reported the overall seroprevalence rates (939
stratified measures), 5 reported seroincidence rates, 4 reported overall
proportions of HSV-2 isolation in GUD (8 stratified proportions), and 24
reported overall proportions of HSV-2 isolation in genital herpes (59
stratified proportions). Pooled HSV-2 seroprevalence among overall
populations was 14.9% (95% confidence interval (CI): 13.8-16.1%) and
was 7.9% (95% CI: 6.9-8.8%) among the general population.
Seroprevalence was highest among key populations (e.g., female sex
workers and men who have sex with men) (32.1% (95% CI: 27.8-36.5%)).
Among the general population, we found northeastern regions had a higher
HSV-2 seroprevalence (12.4%, 95% CI: 7.8-17.9%). HSV-2 seroprevalence
also increased with age. The pooled HSV-2 seroincidence rate was 4.3 per
100 person-years (95% CI: 1.0-7.6). Pooled HSV-2 seroprevalence among
GUD and genital herpes were 45.2% (95% CI: 29.0-61.9%) and 52.8%
(95% CI: 46.6-59.0%), respectively. We also found higher HSV-2
seroprevalence estimates in publications published in English
bibliographic databases than those in Chinese databases (20.5%
vs. 13.6%, risk ratio=1.10 (1.05-1.14)), indicating a potential
existence of language bias in publication. Conclusion: Around 1
in 12 among the general population and 1 in 7 among all included
populations were infected with HSV-2. The data revealed vulnerability to
HSV-2 infection among higher-risk populations calling for expanding the
intervention to prevent HSV-2 infection. It also revealed
heterogeneities in synthesized HSV-2 prevalence results, suggesting the
necessity to include Chinese bibliographic databases in conducting
systematic reviews and meta-analyses of this topic.
Title of the article: Respiratory sequelae after COVID-19 infection in Thai healthy children
Authors: Niamsanit Sirapoom , Boonjindasup Wicharn , Sritippayawan Suchada , Deerojanawong Jitladda , Prapphal Nuanchan , Harnruthakorn Chanthana , Sophonphan Jiratchaya , Niyomkarn Watit
Published: July 2023

Background and Aims: The long-term respiratory sequelae of
COVID-19 infection in children remain poorly understood and may differ
across countries. This study aims to investigate the respiratory
sequelae, including residual respiratory symptoms and pulmonary function
in Thai children. The secondary aim is to identify factors associated
with the respiratory sequelae. Materials and Methods: This is
an observational study involving 56 healthy children, aged between 7-18
years, who were diagnosed with COVID-19 infection from July 2021 to
February 2023. Clinical data relating to COVID-19 infection and
persistent symptoms after the infection were assessed after the
infection up to six months. Spirometry was performed to assess pulmonary
function. Results: Post COVID-19 symptoms were identified in 14
patients (25%), with fatigue, cough, and dyspnea being common symptoms
(28-35%). A significant correlation was found between post COVID-19
symptoms and pneumonia (OR = 6.00, 95%CI [1.54,23.33], p=0.01).
Abnormal pulmonary function was identified in 10 patients (17.8%) with
obstructive impairment being the most common. However, there were no
significant association between clinical factors and pulmonary function
impairment. Conclusion: Prolonged respiratory symptoms and
abnormal pulmonary function following COVID-19 infection are not
uncommon in children. The post COVID-19 symptoms are possibly associated
with COVID-19 pneumonia.
Synergy and Anti-Cooperativity in Allostery: Molecular Dynamics Study of WT and Oncogenic KRAS-RGL1
Authors: Erman Burak , Hacisuleyman Aysima
Published: July 2023

This study focuses on investigating the effects of an oncogenic mutation
(G12V) on the stability and interactions within the KRAS-RGL1 protein
complex. The KRAS-RGL1 complex is of particular interest due to its
relevance to KRAS-associated cancers and the potential for developing
targeted drugs against the KRAS system. The stability of the complex and
the allosteric effects of specific residues are examined to understand
their roles as modulators of complex stability and function. Using
molecular dynamics simulations, we calculate the mutual information, MI,
between two neighboring residues at the interface of the KRAS-RGL1
complex, and employ the concept of interaction information, II, to
measure the contribution of a third residue to the interaction between
interface residue pairs. Negative II indicates synergy, where the
presence of the third residue strengthens the interaction, while
positive II suggests anti-cooperativity. Our findings reveal that MI
serves as a dominant factor in determining the results, with the G12V
mutation increasing the MI between interface residues, indicating
enhanced correlations due to the formation of a more compact structure
in the complex. Interestingly, although II plays a role in understanding
three-body interactions and the impact of distant residues, it is not
significant enough to outweigh the influence of MI in determining the
overall stability of the complex. Nevertheless, II may nonetheless be a
relevant factor to consider in future drug design efforts. This study
provides valuable insights into the mechanisms of complex stability and
function, highlighting the significance of three-body interactions and
the impact of distant residues on the binding stability of the complex.
Additionally, our findings demonstrate that constraining the
fluctuations of a third residue consistently increases the stability of
the G12V variant, making it challenging to weaken complex formation of
the mutated species through allosteric manipulation. The novel
perspective offered by this approach on protein dynamics, function, and
allostery has potential implications for understanding and targeting
other protein complexes involved in vital cellular processes. The
results contribute to our understanding of the effects of oncogenic
mutations on protein-protein interactions and provide a foundation for
future therapeutic interventions in the context of KRAS-associated
cancers and beyond.
How exceptional was the 2015-2019 Central American Drought?
Authors: Anderson Talia G. , McKinnon Karen A. , Pons Diego , Anchukaitis Kevin J.
Published: July 2023

The Central American Dry Corridor experienced five consecutive years of
drought from 2015 to 2019. Here, we find that the severity of this
drought was driven primarily by rainfall deficits in July-August. To
determine if the magnitude of this event was outside the range of
natural variability, we apply a statistical resampling method to
observations that emulates internal climate variability. Our analyses
show that droughts similar to the 2015-2019 event are possible, although
extremely rare, even without anthropogenic influences. Persistent
droughts in our ensemble are consistently linked to positive anomalies
of the Caribbean Low-Level Jet. We also examine the effects of
temperature on soil moisture during this drought using the Palmer
Drought Severity Index and show that anthropogenic warming increases the
likelihood of severe deficits. Multi-year droughts are likely to worsen
by the end of the 21 century due to the compound
effects of anthropogenic climate change.
Descripción de actividad asistencial en las Unidades de Hospitalización a Domicilio de Osakidetza – Servicio Vasco de Salud
Authors: Regalado De Los Cobos José , Ruiz De Gordoa-Campo Garbiñe , Urzay-Atucha Virginia , Azkuenaga-Cruz Irune , Pacho-Beristain Maider , Pascual-Fernandez Nieves
Published: July 2023

Introducción: Las Unidades de Hospitalización a Domicilio (HaD) presentan diferencias en su contenido y condiciones de asistencia. La Sociedad Vasca de HaD inició en 2018 un proyecto de investigación para definir indicadores que permitan comparar la actividad de equipos que tienen contenidos asistenciales diferentes. Una fase del proyecto implicó el registro de características de los episodios atendidos y la atención prestada. Dar a conocer el resultado del registro es de interés.
Método: Entre 1 y 31 de mayo de 2021, 9 Unidades registraron ciertas características de los pacientes atendidos, así como tipo, frecuencia y duración de las visitas realizadas. Se muestran los descriptivos de estas variables en la serie global y en cada Unidad.
Resultados: Se analizaron 1171 episodios y 8363 visitas en 14458 estancias. (82% de estancias reales). De media, en laborable se visitó al 65% de los pacientes y en no laborable al 42%. El porcentaje de casos en cada tipo clínico varió según Unidades: patología aguda entre 12 y 48%; cuidados paliativos entre 20% y 40%; patología quirúrgica entre 2.3 y 30 %. Se apreciaron también diferencias en edad, sexo y dispersión geográfica. Mortalidad y reenvío al hospital variaron entre Unidades y también entre patologías. La duración de la atención directa varió entre Unidades entre 24,4 y 35.9 min, y la del desplazamiento para cada visita entre 11.9 y 25 min, en probable relación con el tipo de patología y la dispersión geográfica respectivamente.
Conclusiones: Se constata que existen diferencias en el contenido y condiciones de trabajo de las distintas Unidades de H a D. Es necesario analizar cómo influyen en las medidas de actividad y de resultado para disponer de indicadores ajustados.
Osteoporosis - treatment gap
Authors: Matijevic Radmila
Published: July 2023

Osteoporosis is defined as a systemic skeletal disease characterized by low
bone mass and microarchitectural deterioration of bone tissue, with a
consequent increase in bone fragility and susceptibility to fracture. The
definition of osteoporosis is based on the T-score for bone mineral density
in women and is defined as a value for bone mineral density of 2.5 standard
deviation or more below the young female adult mean (T-score less than or
equal to ? 2.5). The clinical significance of osteoporosis lies in the
fractures, which are usually the first clinical sign. Approximately one in
two adult women and one in five men will sustain one or more fragility
fractures (defined as a low trauma fracture sustained from a fall from
standing height or less) in their lifetime. More than 9 million osteoporotic
or fragility fractures occur annually across the globe, more than a third of
which happen in Europe. It was estimated that 10.6 out of the 18.4 million
women in Europe who exceeded the threshold risk for osteoporotic fractures
were not treated, representing a treatment gap of 57%. The treatment gap is
considered such a major concern that multiple global health organizations
have issued global calls to tackle this crisis. The increase in the
treatment gap could be accredited to several factors such as misbelief about
osteoporosis, absence of perceived benefits of therapy, concern about side
effects and medication costs, low motivation, and shortfall of patient
education. Several methods have been explored to enable fracture risk
assessment and initiation of appropriate therapy. The multi-disciplinary
Fracture Liaison Service is one of the most successful of these systems.
Pain in focus in patients with osteoarthritis
Authors: Tomasevic-Todorovic Snezana , Spasojevic Tijana
Published: July 2023

Introduction. Peripheral joint osteoarthritis is the leading cause of musculoskeletal pain and functional limitation. Osteoarthritis has a high prevalence and incidence and, therefore great socioeconomic importance. Clinical presentation. Pain in osteoarthritis results from a complex interaction of sensory, affective, and cognitive processes that include numerous abnormal cellular mechanisms at the affected joints and different levels of the nervous system involved in the pathophysiological mechanisms of chronic pain (spinal and supraspinal). In chronic pain states, central nervous system factors are particularly prominent. Although there are several ways to determine pain sensitivity, data suggest that assessing pressure pain threshold (i.e., tenderness to palpation) is the most reliable and reproducible method for identifying individuals with a centralized pain state. Conclusion. Significant advances in our understanding of pain pathophysiology and pain biomarkers are finally making the vision of ?personalized analgesia?. Clinicians can identify the sub-sets of individuals with what were once considered purely ?peripheral? pain syndromes and treat these patients with approaches directed more centrally than peripherally.
Pharmacological osteoarthritis therapy and modern therapeutic principles
Authors: Zvekic-Svorcan Jelena , Minakovic Ivana , Boskovic Ksenija , Simic-Panic Dusica , Mikov Jelena , Igic Natasa
Published: July 2023

Introduction. The purpose of treating osteoarthritis is to relieve pain,
improve the function of the osteoarthritic joint, and arrest further
development of osteoarthritis through non-pharmacological and
pharmacological treatment modalities. Pharmacological osteoarthritis
therapy. In the treatment of osteoarthritis, guidelines and recommendations
are often consulted, but they do not dictate the treatment mode, which is
tailored to the individual needs of the patient. These guidelines promote
desired and positive treatment outcomes, but cannot predict a specific
outcome. They are also valuable when analyzing the use of topical and oral
non-steroidal anti-inflammatory drugs, keeping dosage as low as possible for
the shortest time. For example, monitoring hepatotoxicity is advised when
administering paracetamol, while caution is needed when prescribing drugs
with a central effect due to the possible development of addiction and
appearance of toxic effects. A significant body of research on the use of
chondroprotectors exists, but there is a large discrepancy across studies.
Nonetheless, their findings indicate benefits of intra-articular
administration of glucocorticoids. However, their more frequent
administration can lead to accelerated cartilage loss, while guidelines
differ concerning intra-articular administration of hyaluronic acid, the
administration of plasma enriched with platelets, and the administration of
stem cells due to the heterogeneity of the preparations and the lack of
standardization in their administration. Conclusion. Non-surgical therapy is
a growing field of research, especially from a pharmacological point of
view, intending to find the best treatment to slow down or completely stop
further development of osteoarthritis.
The efficacy of a modality of physical therapy in the treatment of osteoarthritis of the spine - a case report of a patient treated with horizontal therapy
Authors: Nikolov Tatjana , Savic Aleksandra , Jankovic Tanja , Maksimovic-Simovic Marina , Boskovic Ksenija
Published: July 2023

Introduction. Horizontal therapy is the only electrotherapy modality for the
treatment of osteoarthritis that has a simultaneous bioelectrical and
biochemical, effect on deep and superficial joint tissues. The objective of
this report was to provide evidence of efficacy of horizontal therapy in a
patient suffering from lumbar spine osteoarthritis. Case report. A
70-year-old female patient was admitted to the hospital due to severe low
back pain with radiating pain in both legs followed by tingling in left leg.
The patient has had this painful condition since 2010. Physical examination
revealed a reduction of the range of motion of the lumbar spine followed by
spasm of the paraspinal musculature. Deep tendon reflexes of the lower limbs
were 2+ bilaterally, except right patellar reflex which was absent. She had
hypoesthesia in L4, L5 and S1 dermatome of the left leg and no motor
deficits were noted. Radiographic evaluation showed multilevel degenerative
changes of the lumbar spine. The patient was prescribed medication, physical
and exercise therapy. She underwent horizontal therapy for lumbar spine with
a frequency oscillating between 4357 and 12127 hertz. The patient had a
total of 15 treatments, 5 per week and each lasted 30 minutes. Conclusion.
In a patient with osteoarthritis of the spine, horizontal therapy has proved
to be an effective modality of physical therapy leading to pain relief and
functional improvement. Additional clinical research is needed for
confirming its effectiveness on a larger sample, to define optimal
parameters of the application and indication areas.
Hip osteoarthritis - update on etiopathogenesis, clinical presentation and management
Authors: Simic-Panic Dusica , Boskovic Ksenija , Knezevic Aleksandar , Zvekic-Svorcan Jelena , Tomasevic-Todorovic Snezana , Spasojevic Tijana
Published: July 2023

Osteoarthritis is the most frequent form of arthritis, and the hip is the
second most frequently affected joint. The effects of osteoarthritis on the
hip joint often lead to marked physical impairment that can contribute to
increased disability and dependency in everyday activities. Hip
osteoarthritis is a degenerative process with progressive loss of articular
cartilage, followed by a reparative process such as reactive bone
hypertrophy, which causes osteophyte formation and remodelling. The joint
responds with subchondral and synovial inflammation. Patients with hip
osteoarthritis report pain in the groin area which can develop slowly and
worsen over time. With the progression of the disease, the range of motion
of the affected hip is reduced, which affects the walking pattern and may
cause a limp. Therapeutic options for hip osteoarthritis should be based on
the etiopathogenesis of the disease. The approach to treatment for every
patient should be multidisciplinary, multimodal and individualised taking
into account personal beliefs and preferences, social and psychological
factors and prior medical history. It is important to avoid unnecessary
delays in referring patients with advanced hip osteoarthritis for surgical
treatment, in order to prevent worse outcomes after total hip arthroplasty.
The aim of this article is to offer a concise update on etiopathogenesis,
clinical presentation, and management options for hip osteoarthritis.
Organ preservation surgery for laryngeal cancer in a trombone player
Authors: Cukic Ognjen , Milenkovic Aleksandar , Sotirovic Jelena , Milojevic Milanko
Published: July 2023

Introduction. Modern treatments for early glottic carcinoma achieve high rates of local control and long-term survival, but potential side effects of some of these treatments have a substantial impact on a patient?s quality of life. There is a small quantity of available scientific research on the effects of organ-preservation surgery on musicians, highlighting the challenge of balancing functional outcomes with their occupational demands. Case report. We present a successful surgical treatment of a mid-membranous left vocal fold squamous cell carcinoma (T1a stage) in a professional trombonist with a history of many years of smoking. Due to suboptimal exposure during initial microlaryngoscopy, open cordectomy was performed for tumor removal instead of transoral laser microsurgery. After the operation and the proper rehabilitation, the patient continued to play the brass instrument unhindered and managed to fulfill all the obligations of a professional musician in a national orchestra. Conclusion. Selecting a method for the treatment of glottic cancers in professional musicians who play brass instruments remains challenging due to limited literature and the potential harm to the ability of performance and the musician?s career. Partial open laryngectomies for laryngeal cancer treatment are shown to be feasible without compromising the musician?s performance.
Type 1 diabetes genetic risk score differentiates subgroups of Ketosis-Prone Diabetes
Authors: Osafehinti Deborah , N Mulukutla Surya , S Hampe Christiane , Gaba Ruchi , Ram Nalini , N Weedon Michael , A Oram Richard , Balasubramanyam Ashok
Published: July 2023

Objective: To determine if genetic risk for type 1 diabetes (T1D) differentiates the four “Ab” subgroups of Ketosis-Prone Diabetes (KPD), where “A+” and “A-” define presence or absence of islet autoantibodies and “b+” and “b-” define presence or absence of beta cell function.

Research Design and Methods: We compared T1D genetic risk scores (GRS) of KPD patients across subgroups, race/ethnicity, beta cell function and glycemia. 

Results: Among 426 KPD patients (54% Hispanic, 31% African American, 11% White), rank-order of GRS was A+b- > A+b+ = A-b- > A-b+. GRS of A+b- KPD was lower than that of a T1D cohort and GRS of A-b+ KPD was higher than that of a T2D cohort. GRS was lowest among African American patients with a similar distribution across KPD subgroups.

Conclusions: T1D genetic risk delineates etiological differences between KPD subgroups. A+b- KPD patients have the highest and A-b+ KPD patients the lowest GRS. 
The Effect of Ground and Unground Enamel on the Clinical Performance of Direct Composite Build-up After Orthodontic Treatment: Five Years of Follow-up
Authors: Demirci M , Tuncer S , Tekçe N , Öztaş E , Baydemir C
Published: July 2023

Purpose

To assess the clinical performance of restorations with ground and unground enamel for diastema closure.

Methods and Materials

Twenty-four patients attended and received two to ten composite build-ups for diastema closure. The restorations were performed separately by grinding and not grinding the enamel on the proximal surfaces on symmetric teeth. A nanofill direct composite (Filtek Ultimate Universal Restorative System, 3M ESPE, St Paul, MN, USA) was used with a three-step etch-and-rinse adhesive (Scotchbond Multi-Purpose, 3M ESPE) for restorations. Restorations were evaluated according to the modified United States Public Health Service (USPHS) criteria at baseline and 1-, 2-, 3-, 4-, and 5-year recalls.

Results

The cumulative success rate of direct composite build-up with ground and unground enamel was 100% and 88.7%, respectively. Six restorations with unground enamel failed due to fracture. No significant difference was found between the restorations with ground enamel and unground enamel with regard to the evaluation criteria.

Conclusion

The 5-year success rates of restorations with ground and unground enamel were excellent. The success rate of restorations with ground enamel was higher than that of restorations with unground enamel. Fracture was the reason for failure in the restorations with unground enamel.
The determination of total antioxidant activity, phenolic substance and reducing power amounts of hazelnut (Corylus avellana L.) leaves grown in Giresun
Authors: AYDIN BERKTAŞ Özlem
Published: July 2023

In the present study, total antioxidant activity (TAC), phenolic compound amounts (TPC) and reducing power (RP) of hazelnut leaves collected from Giresun were investigated. Antioxidant levels were determined in the water extracts of hazelnut leaves by using methods according to the appropriate literature. In the results obtained from water extracts at three different doses (1, 2.5 and 5 mg/kg), it was determined that the total antioxidant capacity was high depending on the dose and phenolic content. The high antioxidant capacity of hazelnuts produced in humid regions in our country also depends on the phenolic substance content it has.
Proposed Strategy of Heavy Equipment Overhaul: Case Study of a Coal Mining Contractor in Indonesia
Authors: Saputra Rahardian A. , Yudoko Gatot , Firman Aries F.
Published: July 2023

The ICE Newcastle's coal price jumped sharply to an all-time high in the first half of 2022 at $440 from $50 during the peak of the COVID-19 pandemic in Q3 2020. Indonesia took advantage of the situation, not only the government and mining owners (mining license holders) which are preparing all the resources to rapidly increase capacity, but also the mining contractors who serve mining owners are forced to pursue this opportunity. The opportunity must be followed by the preparation such as manpower, infrastructure, and heavy equipment. All companies are doing the same way to compete in increasing their capacity, so the problem is the availability of heavy equipment that is limited in bullish conditions. Overhauling the existing heavy equipment is one of the solutions because instead of ensuring the heavy equipment availability, the overhaul maintenance also gives a benefit for a cheaper price upfront (50%-70% of the new heavy equipment). However, that condition impacted too on the overhaul maintenance such as the difficulties in planning the number of overhauls, lack of preparation manpower, the material rarity, etc. Meanwhile, overhaul execution requires several resources that are ready at the time before the start of execution, so the preparation of the overhaul maintenance in fluctuation conditions is challenging. Determine the proposed strategy for overhaul maintenance to tackle the issue in the future and how to implement should be defined to prevent obstacles for mining contractor business, especially in overhaul maintenance for company Alpha.
Once Upon a Time-Integrating Fairy Tales Into Physics Education: The Case of Mechanics
Authors: Kotsis Konstantinos T. , Tsiouri Eleftheria
Published: July 2023

Fairy tales have long captivated the imaginations of children and adults alike, offering enchanting narratives that transport readers to magical realms. However, the potential for a unique and engaging approach to science education lies beneath the surface of these captivating stories. This paper explores the use of fairy tales as a pedagogical tool in physics education. By integrating scientific concepts into the fabric of well-known fairy tales, educators can leverage the power of storytelling to ignite curiosity, promote critical thinking, and enhance understanding of complex physics principles. This interdisciplinary approach bridges the gap between the fantastical and the factual, fostering a deeper appreciation for scientific inquiry and encouraging students to participate actively in their learning journey.
Nilai Kadar Kortisol Serum Pada Pemain Futsal Malam Hari
Authors: Jayadilaga Yadi , Putra Roy Try , Handayani Meliana
Published: July 2023

The factor of busy working hours causes many people to choose to exercise at night. This study aims to determine the value of cortisol levels in night futsal players. This type of research is descriptive observational research with 15 futsal players as subjects. The data collection technique was carried out by measuring the value of serum cortisol levels using an enzyme linked immunosorbent assay. The results showed that of the 15 subjects, the lowest cortisol level in night futsal players was 0.54 µg/dl and the highest cortisol level was 1.69 µg/dl. Furthermore, the average value of cortisol levels at night futsal players is 1.09 µg/dl. The results of this study revealed that the value of serum cortisol levels in night futsal players was at a normal level

Faktor jam kerja yang padat menyebabkan banyak masyarakat memilih berolahraga pada malam hari. Penelitian ini bertujuan untuk mengetahui nilai kadar kortisol pada pemain futsal malam hari. Jenis penelitian adalah penelitain deskriptif observasional dengan jumlah subjek 15 orang pemain futsal. Teknik pengumpulan data dilakukan dengan mengukur nilai kadar kortisol serum menggunakan alat enzyme linked immunosorbent assay. Hasil penelitian menunjukkan bahwa dari 15 subjek, kadar kortisol paling rendah pada pemain futsal di malam hari adalah 0,54 µg/dl dan kadar kortisol tertinggi adalah 1,69 µg/dl. Selanjutnya, nilai rata-rata kadar kortisol pemain futsal malam hari adalah 1,09 µg/dl. Hasil penelitian ini mengungkapkan bahwa nilai kadar kortisol serum pada pemain futsal malam hari berada pada level normal.
Si-GEMAS: Serious game mathematical crossword puzzle learning media for students critical thinking ability
Authors: Cholily Yus Mochamad , Darmayanti Rani , Lovat Terence , Choirudin Choirudin , Usmiyatun Usmiyatun , Muhammad Ilham
Published: July 2023

Critical personality is a skill that must be possessed in order to survive in the global competition of 21st-century society. Given that critical thinking education is an essential part of human life, innovations must be carried out to foster students' critical thinking. One of his studies was the innovation of crossword learning media (Si-GEMAS). This study aimed to develop Si-GEMAS learning media for the mathematical critical thinking skills of Grade VIII SMP students at YALCP Pasuruan, which are valid, practical, and effective in the learning process. This is intended to determine its validity and efficiency. This research specialty was based on the Borg n Gall development model. The research subjects were ten students of class VIII. The instruments used were validation sheets, teacher and student response questionnaires, and student learning outcomes tests. The results showed that the relevance score of Si-GEMAS learning media with students' critical thinking skills was in the very valid category and efficient. It shows that the Si-GEMAS media was valid and efficient. It increases students' critical thinking from an average of 65.67 to 88.28. It shows that there is an increase of 22.61. So it can help students develop critical thinking skills in learning.