bluuebunny/crossref_metadata_2025 huggingface dataset:
Adverse cardiac remodeling is absent in patients with true controlled resistant hypertension
Authors: Matanes Faris , Siddiqui Mohammed , Velasco Alejandro , Sharifov Oleg , Kreps Eric , Dudenbostel Tanja , Judd Eric K , Zhang Bin , Lloyd Steven G , Oparil Suzanne , Calhoun David A
Published: April 2023

Resistant hypertension (RHTN), defined as blood pressure (BP) that is uncontrolled with ≥3 medications, including a long‐acting thiazide diuretic, also includes a subset with BP that is controlled with ≥4 medications, so‐called controlled RHTN. This resistance is attributed to intravascular volume excess. Patients with RHTN overall have a higher prevalence of left ventricular hypertrophy (LVH) and diastolic dysfunction compared to patients with non‐RHTN. We tested the hypothesis that patients with controlled RHTN due to the intravascular volume excess have higher left ventricular mass index (LVMI), higher prevalence of LVH, larger intracardiac volumes, and more diastolic dysfunction compared to patients with controlled non‐resistant hypertension (CHTN), defined as BP controlled with ≤3 anti‐hypertensive medications. Patients with controlled RHTN (n = 69) or CHTN (n = 63) who were treated at the University of Alabama at Birmingham were offered enrollment and underwent cardiac magnetic resonance imaging. Diastolic function was assessed by peak filling rate, time needed in diastole to recover 80% of stroke volume, E:A ratios and left atrial volume. LVMI was higher in patients with controlled RHTN (64.4 ± 22.5 vs 56.9 ± 11.5; P = .017). Intracardiac volumes were similar in both groups. Diastolic function parameters were not significantly different between groups. There were no significant differences in age, gender, race, body mass index, dyslipidemia between the two groups. The findings show that patients with controlled RHTN have higher LVMI, but comparable diastolic function to those of patients with CHTN.
Perioperative risk factors for neurological impairment in infants with acute liver failure following liver transplantation
Authors: Ide Kentaro , Uchida Hajime , Sakamoto Seisuke , Hayakawa Itaru , Nakagawa Satoshi , Kobayashi Tohru , Ito Shuichi , Kasahara Mureo
Published: April 2023

Background

Neurological impairment is not rare in infants with acute liver failure (ALF). This study aimed to investigate the perioperative risk factors for neurological impairment following liver transplantation (LT) in infantile ALF.

Methods

Retrospective analysis was performed in infants who were younger than 1 year with ALF who subsequently underwent LT at our hospital between January 2005 and December 2016. Patients were considered to have neurological impairment if the Pediatric Cerebral Performance Category score was between 2 and 5 at the age of 6 years. A comparison between the groups of infants with and without neurological impairment was performed, and factors with p < .10 in the comparison were analyzed using univariate logistic regression analysis for neurological impairment.

Results

Twenty‐six infants survived until 6 years of age, and 31% (8/26) of them had neurological impairment. Patients with neurological impairment were significantly younger in age at ALF onset, had significantly higher pre‐LT bilirubin and prothrombin time/international normalized ratio, and stayed significantly longer in the intensive care unit than those without neurological impairment. Total bilirubin (odds ratio (OR) = 1.12, 95% confidence interval (CI) 1.02–1.22, p = .012), indirect bilirubin (OR = 1.10, 95% CI 1.01–1.20, p = .025), direct bilirubin (OR = 1.22, 95% CI 1.01–1.47, p = .040), and age in month at ALF (OR = 0.76, 95% CI 0.58–0.999, p = .049) showed significant association with neurological impairment.

Conclusions

High pre‐LT peak bilirubin value and younger age at ALF onset can be perioperative risk factors for neurological impairment after LT in infantile ALF.
Patients’ opinions 10 years after receiving encapsulated porcine islet xenotransplantation without immunosuppression
Authors: Matsumoto Shinichi , Abalovich Adrian , Wynyard Shaun , Carulla Mariana E. , Abalovich David
Published: April 2023

Background

Previously we performed clinical encapsulated neonatal porcine islet transplantation under comprehensive regulation, and demonstrated the efficacy and safety. To analyze the patients’ quality of life (QOL), we assessed patients’ opinions 10 years after islet xenotransplantation.

Methods

Twenty‐one type 1 diabetic patients received microencapsulated neonatal porcine islet transplants in Argentina were enrolled. Seven patients were enrolled in efficacy and safety study and 14 patients were enrolled in safety studies. Patients’ opinions related to the current and pre‐transplant status of diabetes control, blood glucose levels, severe hypoglycemia, and hyperglycemia required hospitalization were analyzed. In addition, opinions related to islet xenotransplantation were assessed.

Results

At the time of this survey, average HbA1c was still significantly lower compared to pre‐transplantation (8.5 ± 0.9 (%) at pre‐transplant and 7.4 ± 0.5(%) at the survey, p < .05) and average insulin dose were also lower (0.95 ± 0.32 (IU/kg) at pre‐transplant and 0.73 ± 0.27 (IU) at the survey). The majority of patients improved diabetes control (71%), blood glucose levels (76%), severe hypoglycemia (86%) and hyperglycemia required hospitalization (76%), and no patients deteriorated in all of the categories when compared with pre‐transplantation. No patients had cancer, or psychological problem, and one patient had a serious adverse event. The majority of patients wanted to recommend this treatment to other patients (76%) and receive booster transplantation (85.7%).

Conclusions

The majority of patients had positive opinions related to the encapsulated porcine islet xenotransplantation 10 years after transplantation.
The complete plastid genome and nuclear ribosomal transcription unit sequences of Spiraea prunifolia f. simpliciflora (Rosaceae)
Authors: CHOI Jeongjin , KIM Wonhee , PARK Jee Young , KANG Jong-Soo , YANG Tae-Jin
Published: April 2023

Spiraea prunifolia f. simpliciflora Nakai is a perennial shrub widely used for horticultural and medicinal purposes. We simultaneously obtained the complete plastid genome (plastome) and nuclear ribosomal gene transcription units, 45S nuclear ribosomal DNA (nrDNA) and 5S nrDNA of S. prunifolia f. simpliciflora, using Illumina short-read data. The plastome is 155,984 bp in length with a canonical quadripartite structure consisting of 84,417 bp of a large single-copy region, 18,887 bp of a short single-copy region, and 26,340 bp of two inverted repeat regions. Overall, a total of 113 genes (79 protein-coding genes, 30 tRNAs, and four rRNAs) were annotated in the plastome. The 45S nrDNA transcription unit is 5,848 bp in length: 1,809 bp, 161 bp, and 3,397 bp for 18S, 5.8S, and 26S, respectively, and 261 bp and 220 bp for internal transcribed spacer (ITS) 1 and ITS 2 regions, respectively. The 5S nrDNA unit is 512 bp, including 121 bp of 5S rRNA and 391 bp of intergenic spacer regions. Phylogenetic analyses showed that the genus Spiraea was monophyletic and sister to the clade of Sibiraea angustata, Petrophytum caespitosum and Kelseya uniflora. Within the genus Spiraea, the sections Calospira and Spiraea were monophyletic, but the sect. Glomerati was nested within the sect. Chamaedryon. In the sect. Glomerati, S. prunifolia f. simpliciflora formed a subclade with S. media, and the subclade was sister to S. thunbergii and S. mongolica. The close relationship between S. prunifolia f. simpliciflora and S. media was also supported by the nrDNA phylogeny, indicating that the plastome and nrDNA sequences assembled in this study belong to the genus Spiraea. The newly reported complete plastome and nrDNA transcription unit sequences of S. prunifolia f. simpliciflora provide useful information for further phylogenetic and evolutionary studies of the genus Spiraea, as well as the family Rosaceae.
New record of an alien plant, Ipomoea cristulata (Convolvulaceae) in Korea
Authors: YOUN Jin-Suk , KIM Jin-Seok , HYUN Chang Woo , PAK Jae-Hong , LEE Woong
Published: April 2023

Ipomoea cristulata Hallier f. (Convolvulaceae), native to the desert regions of the central USA to Mexico, was newly found in Gojeong-ri, Deokgwa-myeon, Namwon-si, Jeollabuk-do. This species can be distinguished from I. coccinea by leaves with 3-5 lobes, hirsute distributed adaxially, and corolla entirely red or orange-red. Its Korean name is ‘Na-bi-ip-yu-hong-cho’ based on its butterfly-shaped leaves. We provide a detailed description, photographs, habitat details, and a taxonomic key to related taxa.
Pedicularis cheilanthifolia var. albida (Orobanchaceae): A new record for the flora of Uttarakhand, India
Authors: SINGH Sunit , THAKUR Sajan , MEHTA J.P. , DUTT Harish Chander
Published: April 2023

The herb Pedicularis cheilanthifolia var. albida (Pennell) P. C. Tsoong is reported and collected for the first time from the Rudraprayag District of Uttarakhand. The species was seen growing along a glacial stream in an alpine region between 4,100 and 4,400 m asl. Morphological characteristics of the species were examined and processed for herbarium deposition. To simplify taxon identification, a brief taxonomic description and illustration of the taxon are provided.
Metagenomes of a Crystallizer Pond from Isla Cristina Saltern in Spain
Authors: García-Roldán Alicia , de la Haba Rafael R. , Vera-Gargallo Blanca , Sánchez-Porro Cristina , Ventosa Antonio
Published: April 2023

The metagenomic sequences of the prokaryotic microbiota from the brine of a crystallizer pond with 42% (wt/vol) salinity of a saltern located in Isla Cristina, Huelva, southwest Spain, were obtained by Illumina. Haloarchaea and members of the bacterial genus
Salinibacter
were the most abundant prokaryotes.
Draft Genome Sequence of Lactobacillus oris BE7N, Isolated from a Healthy Centenarian in Hainan, China
Authors: Li Congyong , Zhao Yiming , Zhang Yinghui , Li Zhuanyu , Sun Gang
Published: April 2023

We present the draft genome sequence of
Lactobacillus oris
strain BE7N, which was isolated from a healthy male centenarian in Hainan, China. The final 2,129,000-bp draft genome has a G+C content of 50.05%. The genome was sequenced using paired-end Illumina sequencing.
Nicotinic Acid Catabolism Modulates Bacterial Mycophagy in Burkholderia gladioli Strain NGJ1
Authors: Das Joyati , Kumar Rahul , Yadav Sunil Kumar , Jha Gopaljee
Published: April 2023

Mycophagy is an important trait through which certain bacteria forage over fungal mycelia and utilize fungal biomass as a nutrient source to thrive in hostile environments. The present study emphasizes that nicotinic acid (NA) is important for bacterial motility and biofilm formation during mycophagy by
Burkholderia gladioli
strain NGJ1.
Human Serum Supplementation Promotes Streptococcus mitis Growth and Induces Specific Transcriptomic Responses
Authors: Wei Yahan , Sturges Camille I. , Palmer Kelli L.
Published: April 2023

S. mitis
is exposed to human serum components during commensalism in the human mouth and bloodstream pathogenesis. However, the physiological effects of serum components on this bacterium remain unclear. Using transcriptomic analyses,
S. mitis
biological processes that respond to the presence of human serum were revealed, improving the fundamental understanding of
S. mitis
physiology in human host conditions.
Stress load and volunteer motivation of patient volunteers in Fangcang shelter hospitals in Shanghai, China during the COVID-19 pandemic: a cross-sectional survey
Authors: Gu Liyan , Liu Fengmei , Wang Ji , Li Jie , Wei Jie , Xu Jiping
Published: April 2023

Objectives

This study aims to assess the volunteer motivation and stress load of patient volunteers in the Fangcang shelter hospitals (FSHs), examine their associations, and explore the potential influence factors of volunteer motivation.

Design

Cross-sectional online survey conducted from 21 April to 20 May 2022.

Setting

Questionnaires were collected from patient volunteers selected by random cluster sampling in the FSHs in Shanghai, China.

Participants

197 participants who met the inclusion criteria as patients who were asymptomatic or presenting with mild symptoms in the FSHs and who volunteered to assist with routine work under quarantined settings.

Outcome measures

We investigated sociodemographic information, stress load and volunteer motivation through an online survey using the Volunteer Function Inventory and the Stress Overload Scale. Comparisons between groups were conducted by applying t-tests or analysis of variance. The correlation between volunteer motivation and stress was analysed by Pearson correlation. Influencing factors of volunteer motivation were determined by multivariable linear regression models. A value of p<0.05 was used to declare statistical significance.

Results

The mean score of volunteer motivation of patient volunteers was 73.24 (SD 12.00), while that of stress load was 46.08 (SD 21.28). The mean scores of the personal vulnerability (PV) and event load (EL), two dimensions of stress load, were 26.99 (SD 12.46) and 19.09 (SD 9.63), respectively. The majority of the participants (136, 69.04%) were grouped in the low (PV)-low (EL) stress category. Participants’ volunteer motivation was negatively correlated with stress load (r=−0.238, p<0.001), as well as PV (r=−0.188, p<0.01) and EL (r=−0.283, p<0.001). Multivariable linear regression analysis identified that the potential influencing factors of volunteer motivation were occupation (B=1.100, 95% CI 0.037 to 2.164, p=0.043), health condition (B=−3.302, 95% CI −5.287 to –1.317, p<0.001) and EL (B=−0.434, 95% CI −0.756 to –0.111, p=0.009). Participants who worked in the public sector, had better health conditions and had lower EL were more likely to have higher volunteer motivation.

Conclusions

Our study suggested that reducing stress load might be a possible pathway to encourage and maintain volunteerism in the FSH context. Implications and suggestions for future research on patient volunteer recruitment and management could be drawn from our findings.
Investigating the effect of early life antibiotic use on asthma and allergy risk in over 600 000 Canadian children: a protocol for a retrospective cohort study in British Columbia and Manitoba
Authors: Lishman Hannah , Nickel Nathan C , Sbihi Hind , Xie Max , Mamun Abdullah , Zhang Bei Yuan , Rose Caren , Janssen Patricia , Roberts Ashley , Azad Meghan B , Turvey Stuart , Patrick David M
Published: April 2023

Introduction

Allergic conditions, such as asthma, hay fever and eczema, are some of the most common conditions impacting children globally. There is a strong incentive to study their determinants to improve their prevention. Asthma, hay fever and eczema are influenced through the same immunological pathway and often copresent in children (‘the atopic march’). Increasing evidence shows a link between infant antibiotic use and the risk of childhood atopic conditions, mediated through gut microbial dysbiosis during immune system maturation, however, the potential for confounding remains. This study will investigate the relationship between infant antibiotic use and risk of allergic conditions in British Columbian and Manitoban children born over 10 years, adjusting for relevant confounders.

Methods and analysis

Provincial administrative datasets will be linked to perform comparable retrospective cohort analyses, using Population Data BC and the Manitoba Population Research Data Repository. All infants born between 2001 and 2011 in BC and Manitoba will be included (approximately 460 000 and 162 500 infants, respectively), following up to age 7. Multivariable logistic regression will determine the outcome risk by the fifth birthday among children who did and did not receive antibiotics before their first birthday. Clinical, demographic and environmental covariates will be explored, and sensitivity analyses performed to reduce confounding by indication.

Ethics and dissemination

The University of British Columbia Research Ethics Board (H19-03255) and University of Manitoba Ethics Board (HS25156 (H2021:328)) have approved this study. Data stewardship committees for all administrative datasets have granted permissions, facilitated by Population Data BC and the Manitoba Centre for Health Policy. Permissions from the Canadian Health Infant Longitudinal Development Study are being sought for breastfeeding data (CP185). Findings will be published in scientific journals and presented at infectious disease and respiratory health conferences. A stakeholder committee will guide and enhance sensitive and impactful communication of the findings to new parents.
Violence against nurses in the emergency department: an observational study
Authors: Chazel Muriel , Alonso Sandrine , Price Jane , Kabani Sarah , Demattei Christophe , Fabbro-Peray Pascale
Published: April 2023

Objective

This study aimed to evaluate the number and risk factors of violent events encountered in the emergency department. An observation grid was developed following interviews with emergency department staff to target the most pertinent information to collect in a prospective study design.

Design

Observational study.

Setting

Emergency department of a tertiary hospital in France.

Outcome measures

Number of violent events occurring during a single shift, recorded over 6 months by two observers. Information collected included time and date of incident; number of male/female staff; number of patients and accompaniers present in the service and the waiting room and length of staff debriefing. Perpetrator, victim and patient information were collected. Victims were followed-up 72 hours later.

Results

Eighty-two periods were observed between November 2015 and April 2016 recording 35 violent incidents affecting 37 perpetrators and 48 victims, equally distributed over the days of the week and months of the year. The median interval until violence was 0 [0–96] min from entry. Eight (23%) events were officially reported, with two (6%) resulting in charges being pressed. No risk factors were significantly associated with violent incidents in multivariate analysis, although there was a tendency towards significance for fewer senior female doctors present (p=0.0787) and a resulting longer debriefing session (p=0.0712).

Conclusions

We confirm the high rate of violence in the emergency department and poor level of official reporting. Strategies should be implemented to anticipate and reduce incidence and encourage reporting by affected staff.

Trial registration number

NCT02116439.
Impact of lifting the mandatory evacuation order after the Fukushima Daiichi Nuclear Power Plant accident on the emergency medical system: a retrospective observational study at Minamisoma City with machine learning analysis
Authors: Yoshimura Hiroki , Yamamoto Chika , Sawano Toyoaki , Nishikawa Yoshitaka , Saito Hiroaki , Nonaka Saori , Zhao Tianchen , Ito Naomi , Tashiro Satoshi , Ozaki Akihiko , Oikawa Tomoyoshi , Tsubokura Masaharu
Published: April 2023

Objectives

This study aimed to identify factors that delayed emergency medical services (EMS) in evacuation order zones after the 2011 Great East Japan Earthquake and Fukushima Daiichi Nuclear Power Plant accident and to investigate how the lifting of the evacuation affected these factors over time.

Design

This research was a retrospective observational study. The primary outcome measure was onsite EMS time. A gradient boosting model and a decision tree were used to find the boundary values for factors that reduce EMS.

Setting

The target area was Minamisoma City, Fukushima, Japan that was partly designated as an evacuation order zone after the 2011 Fukushima disaster, which was lifted due to decreased radiation.

Participants

This study included patients transferred by EMS from 1 January 2013 through 31 October 2018. Patients who were not transported and those transported for community events, interhospital patient transfer and natural disasters were excluded.

Outcome measures

This study evaluated the total EMS time using on-site time which is the time from arrival at the scene to departure to the destination, and other independent factors.

Results

The total number of transports was 12 043. The decision tree revealed that the major factors that prolonged onsite time were time of day and latitude, except for differences by year. While latitude was a major factor in extending on-site time until 2016, the effect of latitude decreased and that of time of day became more significant since 2017. The boundary was located at N37.695° latitude.

Conclusions

The onsite time delay in EMS in evacuation order zones is largely due to regional factors from north to south and the time of day. However, the north-south regional factor decreased with the lifting of evacuation orders.
China Glaucoma Treatment Pattern Study I–Primary Angle-Closure Glaucoma: protocol for a multicentre, retrospective, observational study
Authors: Chen Jinyuan , Du Jie , Xing Xiaoli , Liu Danyan , Jia Zhiyang , Zheng Yajuan , Wang Dan , Guo Wenyi , Jiang Jian , Duan Guoping , Tang Li , Wu Zhengzheng , Lv Peng , Ma Jianjun , Zhu Yihua , Liang Yuanbo , Sun Xin , He Mingguang
Published: April 2023

Introduction

Primary angle-closure glaucoma (PACG) is a leading cause of irreversible blindness globally, and the number of patients with PACG rises every year. Yet, there is a lack of knowledge about the clinical characteristics, therapeutic options and profile of patients with PACG in China. Hence, we design the China Glaucoma Treatment Pattern Study Ⅰ–Primary Angle-Closure Glaucoma (Ch-GTPⅠ). The objective of this paper is to describe the design and methodology of Ch-GTP. The aim of this study is to characterise the profile and trend associated with initial PACG treatment for the last 10 years in China.

Methods

Ch-GTPⅠ is a national multicentre retrospective observational study that will randomly sample from 50 hospitals throughout China. Over 7000 patient records hospitalised for initial PACG treatment from 2011 to 2020 will be selected randomly. The data from electronic medical records will be uploaded to an encrypted online platform that will receive and collate data from all collaborating hospitals. Data abstraction and monitoring will be performed in a standardised manner by trained statisticians to ensure consistency. Systematic data cleaning will also be conducted by statisticians to ensure data integrity before final data storage. The outcomes will include four broad categories: (1) demographics, (2) clinical characteristics, (3) therapeutic strategies and procedures and (4) early outcomes at discharge. The demographic characteristics and early outcomes will be summarised using descriptive statistics. Comparative analyses of characteristics and treatment pattern changing trends for different regions and years will be used to test for significant differences (t-test or Mann-Whitney U test).

Ethics and dissemination

The collaborating hospitals obtained local approval based on a standard ethics application from internal ethics committees or acknowledged an existent ethics approval of the leading institution with approval from internal ethics committees. Due to the retrospective nature, written informed consent from patients was waived by the ethics committee. The results will be published in academic journals and presented at national and international academic conferences.

Trial registration number

ChiCTR2100054643.
An image is worth a thousand words
Authors: Teoh Victoria , Shariff Zakir
Published: April 2023

Introduction

This case involved a 15-year-old boy, who slipped and impaled his left hand on a wooden beam. An initial anterior–posterior radiograph was obtained prior to referral to plastic surgery for further management (figure 1).

Figure 1

Clinical photographs and initial X-ray taken of the impalement injury.

Clinical examination was restricted due to access. The patient reported general pain on limited movement of all digits but normal neurology. He received appropriate initial treatment of broad-spectrum antibiotics and tetanus care in the emergency department. His medical and social history were unremarkable.

Question

What is the next most appropriate intervention?

Immediate removal of the impaled structure under tourniquet control in an operating theatre.

Immediate removal of the impaled structure in the emergency department under nerve block.

Further imaging is needed.

Urgent surgical consultation.
Testing of a novel Valsalva Assist Device with supine and modified positions in healthy volunteers
Authors: FitzGerald Isabel , Ewings Paul , Lang Iain , Appelboam Andy
Published: April 2023

Background

The Valsalva manoeuvre (VM) is used to treat supraventricular tachycardia (SVT) by inducing a vagal response (drop in HR). There is debate as to the best position in which to carry out the VM and how the strain should be delivered in practice. We aimed to compare vagal responses induced with supine and modified VMs using strains delivered with a standardised manometer or novel Valsalva Assist Device (VAD), a simple device to provide resistance to exhalation.

Methods

We conducted a repeated measures randomised trial of four VMs (two supine VM and two modified VMs), in healthy adult volunteers, with strains delivered using an adapted sphygmomanometer (manometer) or a VAD. Changes in HR, pressure and duration of strain and adverse events were monitored and compared between the techniques and devices. The trial was approved by the University of Exeter Medical School Research ethics committee.

Results

75 healthy participants aged 19–55 years were recruited over a 4-month period. A mixed-effects linear regression showed the modified VM resulted in a 3.8 beats per min (bpm) greater drop in HR compared with the supine VM (p=0.002, 95% CI 2.2 to 5.4). VM strains produced by the VAD were of a similar pressure but of slightly shorter duration and resulted in a 1.9 bpm smaller drop in HR compared with the manometer (p=0.01, 95% CI 0.4 to 3.4). There were no differences in adverse events.

Conclusions

Modified VM was associated with a greater drop in HR than a supine VM with no increase in adverse events in healthy volunteers. The VAD can be used to safely generate the recommended VM strain pressure, but produced a smaller drop in HR compared with a manometer and requires modification to enable the recommended strain duration to be achieved consistently.

Trial registration number

NCT03298880.
On the Generators of Quantum Dynamical Semigroups with Invariant Subalgebras
Authors: Hasenöhrl Markus , Caro Matthias C.
Published: April 2023

The problem of characterizing GKLS-generators and CP-maps with an invariant von Neumann algebra [Formula: see text] appeared in different guises in the literature. We prove two unifying results, which hold even for weakly closed *-algebras: first, we show how to construct a normal form for [Formula: see text]-invariant GKLS-generators, if a normal form for [Formula: see text]-invariant CP-maps is known — rendering the two problems essentially equivalent. Second, we provide a normal form for [Formula: see text]-invariant CP-maps if [Formula: see text] is atomic (which includes the finite-dimensional case). As an application we reproduce several results from the literature as direct consequences of our characterizations and thereby point out connections between different fields.
G-Circulant Quantum Markov Semigroups
Authors: Bolaños-Servín Jorge R. , Quezada Roberto , Vázquez-Becerra Josué
Published: April 2023

We broaden the study of circulant Quantum Markov Semigroups (QMS). First, we introduce the notions of [Formula: see text]-circulant GKSL generator and [Formula: see text]-circulant QMS from the circulant case, corresponding to [Formula: see text], to an arbitrary finite group [Formula: see text]. Second, we show that each [Formula: see text]-circulant GKSL generator has a block-diagonal representation [Formula: see text], where [Formula: see text] is a [Formula: see text]-circulant matrix determined by some [Formula: see text]. Denoting by [Formula: see text] the subgroup of [Formula: see text] generated by the support of [Formula: see text], we prove that [Formula: see text] has its own block-diagonal matrix representation [Formula: see text] where [Formula: see text] is an irreducible [Formula: see text]-circulant matrix and [Formula: see text] is the index of [Formula: see text] in [Formula: see text]. Finally, we exploit such block representations to characterize the structure, steady states, and asymptotic evolution of [Formula: see text]-circulant QMSs.
The View from the Inside: A Case Study on the Perceptions of Digital Transformation Phases in Public Administrations
Authors: Edelmann Noella , Steiner Karin , Misuraca Gianluca
Published: April 2023

The digital transformation of public administrations contributes to the re-design and re-structuring of the organizational processes and practices. Research on the digital transformation of public administrations often focuses on responding to the needs and providing benefits to external stakeholders and users, such as citizens and businesses. The study presented here focuses on one specific stakeholder, the employees of a department within the Federal Government of Lower Austria. Using a multi-method and granular qualitative research approach, the results are interpreted in the context of Perez's (2009) four phases of the digital transformation paradigm. The results show how the department is implementing the recommendations made in the literature and digital strategies: an extensive use of ICTs, the development of information-based services, and an acceleration of transactions and interactions with external stakeholders. At the same time, their perspectives point out some barriers regarding the implementation and use of new digital tools such as digital signatures, the legal frameworks at the national and regional level, and the need for an organizational culture that supports innovation. This study empirically contributes to the literature by providing an analysis of the digital transformation of a public administration as perceived by the employees.
Comparative Effect of the Active Substance of Thyme with N‐Acetyl Cysteine on Hematological Parameters and Histopathological Changes of Bone Marrow and Liver in Rat Models of Acetaminophen Toxicity
Authors: Mokhtari Zahra , Raeeszadeh Mahdieh , Akradi Loghman
Published: April 2023

Acetaminophen has always been at the center of attention as a non‐steroidal anti‐inflammatory drug, which is generally associated with the serious side effects on liver and the hematological parameters. This study aimed to compare the effect of N‐acetyl cysteine (NAC) and thyme extract on rat models of acetaminophen‐induced toxicity. The present experimental study was conducted on 48 Wistar rats randomized into six groups, including the control group (no treatment); the Ac group (470 mg/kg of acetaminophen); the Ac + 100Ex, Ac + 200Ex, and Ac + 400Ex groups (acetaminophen + thyme extract at doses of 100, 200, 400 mg/kg); and Ac + NA group (acetaminophen + NAC). After weighing, a blood sample was taken from heart at the end of the period. The measured parameters were hematological, liver biochemical, and oxidative stress profiles. A part of the liver tissue was also fixed for the pathological examinations. The bone marrow was aspirated to check for cellular changes as well. The lowest mean of the final weight and liver weight to body weight ratio was observed in the Ac group. Weight loss was compensated in Ac + NA and Ac + 200Ex groups (P = 0.035). White blood cell (WBC), red blood cell (RBC), Hemoglobin (Hgb), and Hematocrit (HCT) in Ac and Ac + 400Ex groups showed significant differences from those of the other test groups (P < 0.001). Aspartate transaminase (AST), alanine transaminase (ALT), and alkaline phosphatase (ALP) enzymes in Ac + 200Ex and Ac + NA groups showed a significant decrease compared to those of the other treatment groups (P = 0.043). Total antioxidant capacity (TAC) and glutathione peroxidase (GPx) had the lowest levels in Ac and Ac + 400Ex groups, while malondialdehyde (MDA) had the highest content. In this regard, the liver histopathological indices (necrosis, hyperemia, and hemorrhage) in the Ac + 200Ex and Ac + NA groups reached their lowest grades in the treatment groups. The mean number of erythroid and myeloid cells in the Ac group reached the lowest (17.40 ± 3.48). The microscopic appearance of the bone marrow cells was different from normocytosis in the control group to hypocytosis in the Ac and Ac + 400Ex groups. Thymol, as an effective ingredient in thyme extract at a dose of 200 mg/kg compared to NAC, had a unique effect on reducing bone marrow and liver cell‐tissue changes due to the acetaminophen toxicity.
Quantitative Detection of Quartz Sandstone SiO2 Grade Using Polarized Infrared Absorption Spectroscopy with Convolutional Neural Network Model
Authors: Pan Banglong , Cheng Hongwei , Du Shuhua , Yu Hanming , Feng Shaoru , Tang Yi , Du Juan , Xie Huaming
Published: April 2023

As an independent characteristic of electromagnetic radiation, the polarization of light is sensitive to the scattering and absorption characteristics of the mineral particles. The combination of polarization and infrared absorption spectroscopy is conducive to rapidly and accurately detecting the SiO2 content of metallurgical sandstone deposits. In this study, the 8–14 μm polarized infrared absorption spectra and the grade of the sandstone ore samples were used to analyse the spectral characteristics of the sandstone powder samples. Principal component analysis (PCA) and the successive projection algorithm (SPA) were used to reduce the dimension of the original data, first-order derivative, reciprocal logarithm, and multivariate scattering correction (MSC) data. Then, generalized regression neural network (GRNN), partial least squares regression (PLSR), and convolutional neural network (CNN) were employed to establish a hyperspectral prediction model of SiO2 grade. The results show that the quantitative model by the PCA-CNN algorithm has the better prediction precision for the reciprocal logarithm data, with a coefficient of determination (R2), root mean square error (RMSE), and ratio of performance to interquartile range (RPIQ) of 0.907, 0.023, and 5.11, respectively. This method indicates that the polarized infrared absorption spectra and the PCA-CNN model can provide a more robust and significant spectral interpretation than single infrared spectra, and it is expected to be applied to any high-purity quartz deposit type for in situ and rapid analysis.
Occurrence of Terrifying Nightmares after Few Days of Mirtazapine Use in Elderly Patients
Authors: Dell’Osso Liliana , Lorenzi Primo , Nardi Benedetta , Carpita Barbara , Benedetti Francesca , Cremone Ivan Mirko
Published: April 2023

Introduction. Sleep disturbance and insomnia are some of the most frequent complaints in patients suffering from depression. Some common antidepressant with excitatory effects may worsen sleep qualities, whereas others (like mirtazapine), thanks to their antihistaminergic action, are associated with sedative properties and can quickly improve sleep quality. In the case of mirtazapine, even if its mechanisms of action on sleep remain controversial, beneficial changes in sleep pattern may be observable since the first dose and are associated with a faster onset of the antidepressive action. Case Presentation. Despite these documented beneficial effects, we reported five cases of elderly patients (age ranging from 69 to 79) with various diagnoses and comorbidities (severe or recurrent depression, general anxiety disorder, borderline personality disorder, and Parkinson’s disease) assessed during clinical daily routine for whom the use of mirtazapine was linked to the onset of nightmares so impressive and dramatic that made it necessary to interrupt the treatment. Discussion. This peculiar side effect is still scarcely documented, and the literature on this topic remains conflicting; however, considering that the cases were collected in a short range of time, the exacerbation of nightmares caused by mirtazapine may be more frequent than previously believed. Furthermore, some common features shared by all the cases reported have been highlighted such as the onset of the nightmares being chronologically associated with the initiation of the therapy with mirtazapine, the disappearance with the interruption, the similar age range of all, and the occurrence of the episodes described during fall season.
Supplemental File 1 from The Mutational Signature Comprehensive Analysis Toolkit (musicatk) for the Discovery, Prediction, and Exploration of Mutational Signatures
Authors: Chevalier Aaron , Yang Shiyi , Khurshid Zainab , Sahelijo Nathan , Tong Tong , Huggins Jonathan H. , Yajima Masanao , Campbell Joshua D.
Published: April 2023

Plate diagram and derivation of bayesian prediction algorithm
Supplementary Figure Legends and Supplementary Tables 1 through 3 from Characterization of the Activity of the PI3K/mTOR Inhibitor XL765 (SAR245409) in Tumor Models with Diverse Genetic Alterations Affecting the PI3K Pathway
Authors: Yu Peiwen , Laird A. Douglas , Du Xiangnan , Wu Jianming , Won Kwang-Ai , Yamaguchi Kyoko , Hsu Pin Pin , Qian Fawn , Jaeger Christopher T. , Zhang Wentao , Buhr Chris A. , Shen Paula , Abulafia Wendy , Chen Jason , Young Jenny , Plonowski Arthur , Yakes F. Michael , Chu Felix , Lee Michelle , Bentzien Frauke , Lam Sanh Tan , Dale Stephanie , Matthews David J. , Lamb Peter , Foster Paul
Published: April 2023

PDF - 109K, Supplemental Figure Legends. Supplemental Table S1: Kinase profile for XL765a. Supplemental Table S2: XL765 potency on cell proliferation by genotype. Supplemental Table S3: XL765 plasma concentrations, pharmacodynamic assays.
Supplementary Table 2 from Genome-wide siRNA Screen Identifies the Radiosensitizing Effect of Downregulation of MASTL and FOXM1 in NSCLC
Authors: Nagel Remco , Stigter-van Walsum Marijke , Buijze Marijke , van den Berg Jaap , van der Meulen Ida H. , Hodzic Jasmina , Piersma Sander R. , Pham Thang V. , Jiménez Connie R. , van Beusechem Victor W. , Brakenhoff Ruud H.
Published: April 2023

Supplementary Table 2. Proteins phosporylated to a lower extent in SW1573 MASTL knockdown cells in comparison to SW1573 control cells.
Supplementary Figure 1 from Novel ATP-Competitive MEK Inhibitor E6201 Is Effective against Vemurafenib-Resistant Melanoma Harboring the MEK1-C121S Mutation in a Preclinical Model
Authors: Narita Yusuke , Okamoto Kiyoshi , Kawada Megumi Ikemori , Takase Kazuma , Minoshima Yukinori , Kodama Kotaro , Iwata Masao , Miyamoto Norimasa , Sawada Kohei
Published: April 2023

PDF - 83K, Effect of vemurafenib, selumetinib, or E6201 on Cyclin D1 expression in exogenous MEK1-WT-positive or -negative A375 cells.
Supplementary Figure 2 from Characterization of LY2228820 Dimesylate, a Potent and Selective Inhibitor of p38 MAPK with Antitumor Activity
Authors: Campbell Robert M. , Anderson Bryan D. , Brooks Nathan A. , Brooks Harold B. , Chan Edward M. , De Dios Alfonso , Gilmour Raymond , Graff Jeremy R. , Jambrina Enrique , Mader Mary , McCann Denis , Na Songqing , Parsons Stephen H. , Pratt Susan E. , Shih Chuan , Stancato Louis F. , Starling James J. , Tate Courtney , Velasco Juan A. , Wang Yong , Ye Xiang S.
Published: April 2023

PDF file - 90K, shRNA silencing of p38a MAPK in U-87MG glioma (Westerns and xenograft tumor growth data).
Supplementary Table 4 from Marine Sponge Cribrochalina vasculum Compounds Activate Intrinsic Apoptotic Signaling and Inhibit Growth Factor Signaling Cascades in Non–Small Cell Lung Carcinoma
Authors: Zovko Ana , Viktorsson Kristina , Hååg Petra , Kovalerchick Dimitry , Färnegårdh Katarina , Alimonti Andrea , Ilan Micha , Carmeli Shmuel , Lewensohn Rolf
Published: April 2023

Supplementary Table 4: Compound 1 and compound 2 -induced cytotoxicity in tumor and normal cells of different origin. Concentrations that induced 30 %, 50 % and 70 % (IC30, IC50 and IC70) of cell viability reduction in tumor (U-1810, U-1285, H69, H82, A2780, SKOV-3) and normal cells (WI-38, cardiomyocytes, PBMC, BJ-5ta, BEAS-2B, RPE-1) treated for 72 h with compounds 1 or 2 are given. The Area under the dose-response curve (AUC) is calculated for each treatment. The data presented is based on calculation from 3 independent biological replicates and the entire growth curves are shown in Fig. 2C and Fig. 2D.
Supplemental Information from Efficacy of RG7787, a Next-Generation Mesothelin-Targeted Immunotoxin, against Triple-Negative Breast and Gastric Cancers
Authors: Alewine Christine , Xiang Laiman , Yamori Takao , Niederfellner Gerhard , Bosslet Klaus , Pastan Ira
Published: April 2023

Supplemental Information. Includes Supplementary Methods section and legends for Supplemental Figures
Supplementary material and methods from Biological Role and Therapeutic Targeting of TGF-β3 in Glioblastoma
Authors: Seystahl Katharina , Papachristodoulou Alexandros , Burghardt Isabel , Schneider Hannah , Hasenbach Kathy , Janicot Michel , Roth Patrick , Weller Michael
Published: April 2023

Supplementary material and methods
Supplementary Figures S1-S5 and Suppelementary Table ST1 from Tumor-Priming Smoothened Inhibitor Enhances Deposition and Efficacy of Cytotoxic Nanoparticles in a Pancreatic Cancer Model
Authors: Roy Chaudhuri Tista , Straubinger Ninfa L. , Pitoniak Rosemarie F. , Hylander Bonnie L. , Repasky Elizabeth A. , Ma Wen Wee , Straubinger Robert M.
Published: April 2023

Supplemental Figure S1: Histological characteristics of human pancreatic adenocarcinoma #18269 Supplemental Figure S2: Treatment effects on histology of human pancreatic adenocarcinoma #18269 Supplemental Figure S3: Gross morphology of #18269 tumors following administration of vascular permeability probes Supplemental Figure S4: Reversal of SHHI-mediated effects on tumor microvessels by SSL-DXR administration Supplemental Figure S5: Toxicity profiles of treatment groups based on body weight loss Supplemental Table ST1: Comparison of survival after SSL-DXR- vs. free doxorubicin treatment at 8 mg/kg dose
Supplemental Figure 7 from Identification of Novel Radiosensitizers in a High-Throughput, Cell-Based Screen for DSB Repair Inhibitors
Authors: Goglia Alexander G. , Delsite Robert , Luz Antonio N. , Shahbazian David , Salem Ahmed F. , Sundaram Ranjini K. , Chiaravalli Jeanne , Hendrikx Petrus J. , Wilshire Jennifer A. , Jasin Maria , Kluger Harriet M. , Glickman J. Fraser , Powell Simon N. , Bindra Ranjit S.
Published: April 2023

Results for each of the 16 identified hits in the panel of IR foci formation assays, and additional clonogenic survival data.
Supplemental Figures 1-4; Supplemental Tables 2,4,5 from HEXIM1 as a Robust Pharmacodynamic Marker for Monitoring Target Engagement of BET Family Bromodomain Inhibitors in Tumors and Surrogate Tissues
Authors: Lin Xiaoyu , Huang Xiaoli , Uziel Tamar , Hessler Paul , Albert Daniel H. , Roberts-Rapp Lisa A. , McDaniel Keith F. , Kati Warren M. , Shen Yu
Published: April 2023

Supplemental Figure 1. Chemical structure and biochemical potency of BET inhibitors used in this study. Supplemental Figure 2. Rapid reversal of PD marker responses upon BET inhibitor washout in OPM-2 cells. Supplemental Figure 3. In vivo antitumor efficacies of ABBV-075 in the OPM-2 model at the 0.25 mg/kg, qdx21 and 1 mg/kg, qdx21 dose levels. Supplemental Figure 4. Identification of potential PD markers in skin. Supplemental Table 2. Common pathways regulated by MS417 in NCI-H1299 and MiaPaCa-2 cells Supplemental Table 4.Correlation of EC50s of MS417 and ABBV-075 in regulating PD makers vs. their anti-proliferative EC50s in OPM-2 cells. Supplemental Table 5. Identification of potential PD markers in whole blood.
Supplementary Materials and Methods and Supplementary Figures S1-S4 from A Fas Ligand (FasL)-Fused Humanized Antibody Against Tumor-Associated Glycoprotein 72 Selectively Exhibits the Cytotoxic Effect Against Oral Cancer Cells with a Low FasL/Fas Ratio
Authors: Chien Ming-Hsien , Chang Wei-Min , Lee Wei-Jiunn , Chang Yu-Chan , Lai Tsung-Ching , Chan Derek V. , Sharma Rahul , Lin Yuan-Feng , Hsiao Michael
Published: April 2023

1. Supplementary Materials and Methods 2. Figure S1. DNA sequence alignment of Fas or FasL Crispr knockout gene with their parent gene. 3. Figure S2. Cell viability, caspase-3 cleavage and the phosphorylation of ERK1/2, p38, I-κB and NF-κB in Cal-27 cells with Fas neutralization. 4. Figure S3. FasL Crispr knockout enhances the cytotoxic effectiveness of hcc49scFv-FasL on Cal-27 cells. 5. Figure S4. hcc49scFV-FasL fusion protein cannot be cleaved by ADAM10 and MMP-7.
Figure S1 from Combinatorial Treatment with mTOR Inhibitors and Streptozotocin Leads to Synergistic In Vitro and In Vivo Antitumor Effects in Insulinoma Cells
Authors: Bollard Julien , Patte Céline , Massoma Patrick , Goddard Isabelle , Gadot Nicolas , Benslama Noura , Hervieu Valérie , Ferraro-Peyret Carole , Cordier-Bussat Martine , Scoazec Jean-Yves , Roche Colette , Walter Thomas , Vercherat Cécile
Published: April 2023

Figure S1 shows sensitivities of INS-1E and MIN6 cells to streptozotocin, everolimus, MK-22006, BKM120 and BEZ235.
Supplementary Figure S4. from ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment
Authors: Patel Hetal , Periyasamy Manikandan , Sava Georgina P. , Bondke Alexander , Slafer Brian W. , Kroll Sebastian H. B. , Barbazanges Marion , Starkey Richard , Ottaviani Silvia , Harrod Alison , Aboagye Eric O. , Buluwela Laki , Fuchter Matthew J. , Barrett Anthony G. M. , Coombes R. Charles , Ali Simak
Published: April 2023

ADME analysis, oral bioavailability and distribution of ICEC0942.
Supplementary Table S1 from Small Molecule–Mediated Activation of RAS Elicits Biphasic Modulation of Phospho-ERK Levels that Are Regulated through Negative Feedback on SOS1
Authors: Howes Jennifer E. , Akan Denis T. , Burns Michael C. , Rossanese Olivia W. , Waterson Alex G. , Fesik Stephen W.
Published: April 2023

Protein kinase inhibition profile for 1. Compound 1 was tested against a panel of 342 kinases at a single dose concentration of 20 μM. Columns labeled 'Data 1' and 'Data 2' indicate data from technical replicates. Control compound staurosporine was tested in a 10-dose IC50 format using 4-fold serial dilution at a starting concentration of 20 μM. Reactions were carried out using 10 μM ATP. Data shown are normalized to a DMSO vehicle control and displayed as % enzyme activity. ND indicates that compound was not tested against the specific kinase indicated. Compound 1 data are conditionally formatted on a red to green scale so that kinases inhibited to a greater degree are highlighted in red, and kinases inhibited to a lesser degree are highlighted in green. Reaction Biology Corp. conducted the experiments.
Figure S2 from Sprague Dawley Rag2-Null Rats Created from Engineered Spermatogonial Stem Cells Are Immunodeficient and Permissive to Human Xenografts
Authors: Noto Fallon K. , Adjan-Steffey Valeriya , Tong Min , Ravichandran Kameswaran , Zhang Wei , Arey Angela , McClain Christopher B. , Ostertag Eric , Mazhar Sahar , Sangodkar Jaya , DiFeo Analisa , Crawford Jack , Narla Goutham , Jamling Tseten Y.
Published: April 2023

Western Blot analysis for RAG2 protein expression in SDR rats. Rat thymus and spleen lysates were loaded onto a 7.5% SDS-PAGE gel and probed with a RAG2 polyclonal antibody at a dilution of 1:1000.
Figure S2 from Restricted Delivery of Talazoparib Across the Blood–Brain Barrier Limits the Sensitizing Effects of PARP Inhibition on Temozolomide Therapy in Glioblastoma
Authors: Kizilbash Sani H. , Gupta Shiv K. , Chang Kenneth , Kawashima Ryo , Parrish Karen E. , Carlson Brett L. , Bakken Katrina K. , Mladek Ann C. , Schroeder Mark A. , Decker Paul A. , Kitange Gaspar J. , Shen Yuqiao , Feng Ying , Protter Andrew A. , Elmquist William F. , Sarkaria Jann N.
Published: April 2023

Evaluation of sensitizing effects of TAL in GBM cell lines by clonogenic assay