bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing the Efficacy of a Bouchot-Style Shellfish Reef as a Restoration Option in a Temperate Estuary
Authors: Maus Charles , Cottingham Alan , Bossie Andrew , Tweedley James R.
Published: January 2024

Shellfish reefs around the world have become degraded, and recent efforts have focused on restoring these valuable habitats. This study is the first to assess the efficacy of a bouchot-style reef, where mussels were seeded onto wooden stakes and deployed in a hypereutrophic estuary in Australia. While >60% of translocated mussels survived one month, after ten months, only 2% remained alive, with this mortality being accompanied, at least initially, by declining body condition. Mussel survival, growth, body condition and recruitment were greater on the top section of the stake, implying that the distance from the substrate was important. More fish species inhabited the reefs (31) than unstructured control sites (17). Reefs were also colonised by a range of invertebrate species, including 11 native and six non-indigenous species. However, the number of individuals declined from 4495 individuals from 14 species in December 2019 to 35 individuals representing 4 species in March 2021, likely due to hypoxic bottom water conditions following unseasonal rainfall. Although the bouchot-style reefs were unable to sustain mussels and other invertebrates over sequential years, this approach has the potential to be successful if deployed in shallow water or intertidal zones, which are largely exempt from biotic and abiotic stressors characteristic of deeper waters in microtidal estuaries.
Wrinkling of Toroidal Shells in Free Hydroforming
Authors: Liu Xiaobin , Zhang Jian , Zhan Ming , Zhao Xilu , Wu Wenwei , Xu Kaiwei
Published: January 2024

In this study, we investigated toroidal shell wrinkling in free hydroforming. We specifically focused on toroidal shells with a regular hexagonal cross-section. Membrane theory was used to examine the distribution of stress and yield load in both preform and toroidal shells. The wrinkling moment was then predicted using an empirical formula of shell buckling. In addition, the wrinkling state was investigated using a general statics method, and the free hydroforming of toroidal shells was simulated using the Riks method. Subsequently, nonlinear buckling and equilibrium paths were analyzed. A toroidal preform was manufactured, and free hydroforming experiments were conducted. Overall, the experimental results confirmed the accuracy of the theoretical predictions and numerical simulations. This indicates that the prediction method used in the study was effective. We also found that wrinkling occurs during hydroforming in the inner region of toroidal shells due to compressive stress. Consequently, we improved the structure of the toroidal shells and performed analytical calculations and numerical simulations for the analysis. Our results indicate that wrinkling can be eliminated by increasing the number of segments on the inner side of toroidal preforms, thereby improving the quality of toroidal shells.
The Role of the 18F-FDG PET/CT in the Management of Patients Suspected of Cardiac Implantable Electronic Devices’ Infection
Authors: Pisani Antonio Rosario , Rubini Dino , Altini Corinna , Ruta Rossella , Gazzilli Maria , Sardaro Angela , Iuele Francesca , Maggialetti Nicola , Rubini Giuseppe
Published: January 2024

Background: Infection of Cardiac Implantable Electronic Devices (CIEDI) is a real public health problem. The main aim of this study was to determine the diagnostic performance of 18F-FDG PET/CT in the diagnosis of CIEDI. Methods: A total of 48 patients, who performed 18F-FDG PET/CT for the clinical suspicion of CIEDI were retrospectively analyzed; all patients were provided with a model with procedural recommendations before the exam. Sensitivity (Se), specificity (Sp), positive predictive value (PPV), negative predictive value (NPV) and diagnostic accuracy (DA) of 18F-FDG PET/CT were calculated; the reproducibility of qualitative analysis was assessed with Cohen’s κ test. The semi-quantitative parameters (SUVmax, SQR and TBR) were evaluated in CIEDI+ and CIEDI− patients using the Student’ t-test; ROC curves were elaborated to detect cut-off values. The trend of image quality with regards to procedural recommendation adherence was evaluated. Results: Se, Sp, PPV, NPV and DA were respectively 96.2%, 81.8%, 86.2%, 94.7% and 89.6%. The reproducibility of qualitative analysis was excellent (K = 0.89). Semiquantitative parameters resulted statistically different in CIEDI+ and CIEDI− patients. Cut-off values were SUVmax = 2.625, SQR = 3.766 and TBR = 1.29. Trend curves showed increasing image quality due to adherence to procedural recommendations. Conclusions: 18F-FDG-PET/CT is a valid tool in the management of patients suspected of CIEDI and adherence to procedural recommendations improves its image quality.
Clinical, Technical, and MRI Features Associated with Patients’ Outcome at 3 Months and 2 Years following Prostate Artery Embolization: Is There an Added Value of Radiomics?
Authors: Martin Antoine , Marcelin Clément , Petitpierre François , Jambon Eva , Maaloum Rim , Grenier Nicolas , Le Bras Yann , Crombé Amandine
Published: January 2024

Our aim was to investigate which features were associated with clinical successes at short- and mid-terms following prostate artery embolization (PAE) for symptomatic benign prostate hypertrophy (BPH). All adults treated by PAE for BPH at our referral center between January 2017 and March 2021, with pre-treatment MRI, technical success, and follow-up at 3 months and 2 years were included in this single-center retrospective study. Radiologists reviewed the prostatic protrusion index (PPI), adenomatous dominant BPH (adBPH), and Wasserman classification on pre-treatment MRI. Radiomics analysis was achieved on the transitional zone on pre-treatment T2-weighted imaging (WI) and ADC, and comprised reproducibility assessment, unsupervised classifications, and supervised radiomics scores obtained with cross-validated Elasticnet regressions. Eighty-eight patients were included (median age: 65 years), with 81.8% clinical successes at 3 months and 60.2% at 2 years. No feature was associated with success at 3 months, except the radiomics score trained on T2-WI and ADC (AUROC = 0.694). Regarding success at 2 years, no radiomics approaches provided significant performances; however, Wasserman type-1 and change in international prostate symptom score (IPSS) at 3 months ≤ −35% were associated with success in multivariable analysis (OR = 5.82, p = 0.0296, and OR = 9.04, p = 0.0002). Thus, while radiomics provided limited interest, Wasserman classification and early IPSS changes appeared predictive of mid-term outcomes.
Carbon Stock in Coastal Ecosystems of Tombolos of the White and Baltic Seas
Authors: Bagdasarov Ilya , Tseits Michail , Kryukova Iuliia , Taskina Kseniya , Bobrik Anna , Ilichev Igor , Cheng Junxiang , Xu Ligang , Krasilnikov Pavel
Published: January 2024

“Blue carbon”, apart from marine humus, includes the carbon (C) stock of coastal ecosystems such as mangroves, saltmarshes, and seagrass meadows, which have been overlooked until recently. Information about the role of coastal wetlands in C sequestration and providing other ecosystem services is still insufficient. In the present study, we assessed the C reserves of soils and vegetation biomass in two complex coastal landscapes (tombolos) located on the coasts of the White and Baltic seas. The soil and plant C stocks were slightly higher at the plot on the Baltic Sea (93.4 ± 46.7 Mg C·ha−1 and 5.22 ± 2.51 Mg C·ha−1, respectively) than at the plot on the White Sea (71.4 ± 38.2 Mg C·ha−1 and 3.95 ± 2.42 Mg C·ha−1, respectively). We attributed the higher values of the C reserved to a warmer climate and less saline water at the plot on the Baltic Sea. Both soil and plant C showed high heterogeneity due to geomorphological complexity and differences in vegetative communities. The Phragmites australis community showed the highest plant biomass and, in some places, high soil C reserves. Allochthonous C contributed to the soil C stock at the site on the White Sea. Though P. australis sequestered more C than other communities, its effect on ecosystem services was mostly negative because the invasion of reeds reduced the biological diversity of the marshes.
Interdependence in Coastal Tourist Territories between Marine Litter and Immediate Tourist Zoning Density: Methodological Approach for Urban Sustainable Development
Authors: López-Arquillo Juan Diego , Oliveira Cristiana , Serrano González Jose , Durán Sánchez Amador
Published: January 2024

The coastal strip, characterized by the urbanization of coastal tourist territories (CTTs), has expanded over decades through civil engineering, altering the shoreline dynamics and creating artificial beaches crucial for tourism. To examine the relationship between extensive land use in CTTs for tourism and residences and the presence of marine litter, a specific parametric study was conducted along the coast of Tenerife, the largest island in the Canary Islands. Due to Tenerife’s geographical location and exposure to the descending Gulf Stream flow, the coastal waters in the selected zone experience waste impact at both local and global scales. However, the presence of marine litter deposited by ocean currents is at a micro level and falls outside the scope of this report. This study parameterised urban reality in study areas, and the presence of macro waste has been parameterised using standardised units of measurement. This enables the establishment of source measurements that will contribute to preventative measures against this type of coastal pollution. The interdependence between tourist zoning, civil seafront engineering works along the seafront, and marine litter presence in inaccessible and visible areas for tourists requires a methodology to better understand waste origin and loading areas. This knowledge is crucial for an effective local monitoring system. A quantitative overlay reading methodology has been designed in the urban setting through calculations of urban densities, while examining the waste in these areas’ immediate infralittoral flooring through the use of visual underwater extraction. Anticipating the type and quantity of waste in each area will allow for the implementation of effective awareness, promoting action for preventative and corrective measures at the urban level. The results show a direct dependence between urban density and the presence of waste, as well as an equation that makes it possible to anticipate the amount of waste according to urban density and its relational vector. There is no discontinuity between them, as each area is affected by others to the extent that they establish the parametric continuity conditions determining each field. Therefore, it is possible to relate them beyond a one-on-one relationship. This approach fosters sustainable tourism development, reducing pressure on the sea and enhancing the utilisation of tourism revenues in measures to address waste-related challenges and promotes sustainable tourism development in Europe’s coastal regions.
Scenario Analysis of Carbon Emission Changes Resulting from a Rural Residential Land Decrement Strategy: A Case Study in China
Authors: Xu Feng , Chi Guangqing , Wang Huan
Published: January 2024

Greening the unused or inefficient land surface is of vital importance to increase the carbon pool in environmentally fragile but depopulated rural areas. A proactive land-use strategy, rural residential land decrement (RRLD), is triggered by rural land abandonment and can contribute to greening the land surface. A RRLD can be designed and implemented according to the specific regulations and rules and linked to regional environmental change. However, the carbon consequences of implementing multi-scenario RRLDs remain unknown. Thus, this study exemplifies a rural county of China, proposes a framework that illustrates how spatial zoning, decision model, and prediction techniques jointly determine the RRLD, and accounts for the associated carbon emissions under three scenarios. The results demonstrate that half of the 2012.23 hectares of RRLs were recommended for conversion to farming or gardening use. Under the scenarios of agricultural priority, compact ecological priority, and complete ecological priority, the change of carbon emission capacity in one township could be up to 77.41 tCO2 yr−1, −172.32 tCO2 yr−1, and −209.07 tCO2 yr−1. The total change of Fang’s carbon budget ranged from −1179.91 tCO2 yr−1 (sequestration) to 461.53 tCO2 yr−1 (emission). The findings provide a practical paradigm for utilizing land-use strategies to improve the carbon-related environment.
Physico-Mechanical Properties and Hydration Processes of Cement Pastes Modified with Pumice, Trass and Waste Chalcedonite Powder
Authors: Spychał Edyta , Vyšvařil Martin
Published: January 2024

In this article, the physico-mechanical properties and hydration processes of cement pastes containing three additives are introduced. Cement was replaced with pumice, trass, waste chalcedonite powder at 30% by mass and a combination of pumice or trass and waste chalcedonite powder in the amounts of 15% each. The main aim of this research was to assess the properties of two- or three-component binders to save cement in these binders. Rheological properties such as consistency, yield stress, viscosity and thixotropy were determined, in addition to porosity, 7-day and 28-day flexural and compressive strength and bulk density. Additionally, the heat evolution and degree of hydration of the tested pastes were compared. The use of all additives resulted in a reduction in the consistency of the tested pastes. The highest compressive strength measured after 28 days was observed for the cement paste with a 30% content of waste chalcedonite powder, which is related to it having the best pozzolanic activity of the materials used. The results of this research have confirmed that pumice, trass and waste chalcedonite powder can be used as components of blended Portland cements.
Chirality in Atomically Thin CdSe Nanoplatelets Capped with Thiol-Free Amino Acid Ligands: Circular Dichroism vs. Carboxylate Group Coordination
Authors: Kurtina Daria A. , Zaytsev Vladimir B. , Vasiliev Roman B.
Published: January 2024

Chiral semiconductor nanostructures and nanoparticles are promising materials for applications in biological sensing, enantioselective separation, photonics, and spin-polarized devices. Here, we studied the induction of chirality in atomically thin only two-monolayer-thick CdSe nanoplatelets (NPLs) grown using a colloidal method and exchanged with L-alanine and L-phenylalanine as model thiol-free chiral ligands. We have developed a novel two-step approach to completely exchange the native oleic acid ligands for chiral amino acids at the basal planes of NPLs. We performed an analysis of the optical and chiroptical properties of the chiral CdSe nanoplatelets with amino acids, which was supplemented by an analysis of the composition and coordination of ligands. After the exchange, the nanoplatelets retained heavy-hole, light-hole, and spin-orbit split-off exciton absorbance and bright heavy-hole exciton luminescence. Capping with thiol-free enantiomer amino acid ligands induced the pronounced chirality of excitons in the nanoplatelets, as proven by circular dichroism spectroscopy, with a high dissymmetry g-factor of up to 3.4 × 10−3 achieved for heavy-hole excitons in the case of L-phenylalanine.
Using Thin Films of Phase-Change Material for Active Tuning of Terahertz Waves Scattering on Dielectric Cylinders
Authors: Cakmak Atilla Ozgur , Colak Evrim , Serebryannikov Andriy E.
Published: January 2024

The scattering of electromagnetic waves by isotropic dielectric cylinders can be dramatically modified by means of vanadium dioxide (VO2) thin-film coatings. Efficient dynamic control of scattering is achieved due to the variations in material parameters realizable by means of external biasing. In this paper, we study the scattering of terahertz waves in a case where the coating shells are made of VO2, a phase-change material, whose thin films may work rather as electromagnetic phase screens in the insulator material phase, but as lossy quasi-metallic components in the metallic material phase. The shells that uniformly cover the dielectric cylinders are investigated. Attention will be paid to the demonstration of the potential of VO2 in the external control of diverse scattering regimes of the dielectric-VO2 core–shell scatterer, while conductivity of VO2 corresponds to rather insignificant variations in temperature. In line with the purposes of this work, it is shown that the different resonant and nonresonant regimes have different sensitivity to the variations in VO2 conductivity. Both the total scattering cross section and field distributions inside and around the core are studied, as well as the angle-dependent scattering cross section.
An Approach to Multidimensional Discrete Generating Series
Authors: Akhtamova Svetlana S. , Cuchta Tom , Lyapin Alexander P.
Published: January 2024

We extend existing functional relationships for the discrete generating series associated with a single-variable linear polynomial coefficient difference equation to the multivariable case.
Efficacy of Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor on Clinical Parameters in Patients with Heart Failure
Authors: Yazaki Mayu , Nabeta Takeru , Takigami Yu , Eda Yuko , Fujita Teppei , Iida Yuichiro , Ikeda Yuki , Ishii Shunsuke , Ako Junya
Published: January 2024

Background and Objectives: Hypoxia-inducible factor prolyl hydroxylase (HIF-PH) inhibitors have been approved as an oral drug for treating anemia in chronic kidney disease (CKD). However, the clinical effect of HIF-PH inhibitors in patients with heart failure (HF) is unclear. Thus, this study investigated the effect of HIF-PH inhibitors in patients with HF and CKD. Materials and Methods: Thirteen patients with HF complicated by renal anemia who were started on vadadustat were enrolled. Clinical parameters were compared before and 1 month after vadadustat was started. Results: The mean left ventricular ejection fraction was 49.8 ± 13.9%, and the mean estimated glomerular filtration rate was 29.4 ± 10.6 mL/min/1.73 m2. The hemoglobin level was significantly increased (9.7 ± 1.3 mg/dL vs. 11.3 ± 1.3 mg/dL, p < 0.001), and the N-terminal prohormone of B-type natriuretic peptide was significantly decreased after the introduction of vadadustat [4357 (2651−15182) pg/mL vs. 2367 (1719−9347) pg/mL, p = 0.002]. Furthermore, the number of patients with New York Heart Association functional class ≥ 3 was also decreased after the introduction of vadadustat [8 (61.5%) vs. 1 (7.7%), p = 0.008]. No thromboembolic adverse events or new tumors were observed in any patient during the study period. Conclusions: The introduction of vadadustat in patients with HF complicated by renal anemia led to improvements in anemia and symptoms of HF.
Predictive Capabilities of Human Leukocyte Antigen-G and Galectin-13 Levels in the Amniotic Fluid and Maternal Blood for the Pregnancy Outcome
Authors: Vincze Márió , Sikovanyecz János , Molnár András , Földesi Imre , Surányi Andrea , Várbíró Szabolcs , Németh Gábor , Sikovanyecz János , Kozinszky Zoltan
Published: January 2024

Background and Objectives: Increasing evidence points to the significant role of the angiogenic factor levels in screening for pregnancy outcome. To examine the potential relationship between concentrations of placental protein 13 (PP13) and soluble human leukocyte antigen-G (sHLA-G) in maternal serum and amniotic fluid at 16–23 weeks of gestation and the sonographic features of pregnancy as well as pregnancy outcome. Materials and Methods: PP13 and sHLA-G in serum and amniotic fluid, fetal biometrical data, and placental volume and perfusion indices were determined in 71 euploid, singleton pregnancies. Results: The serum sHLA-G level exhibits a negative correlation with the serum PP13 level (r = −0.186, p < 0.001) and a positive correlation with the sHLA-G level in amniotic fluid (r = 0.662, p < 0.001). A significant correlation was found between serum sHLA-G level and placental volume (r = 0.142, p < 0.05) and between amniotic sHLA-G level and placental perfusion (r = −0.450, p < 0.001). A low amniotic PP13 level significantly predicted the birth weight (r = −0.102, p < 0.05), the duration of pregnancy (r = −0.155, p < 0.05), and the fetal abdominal circumference (r = −0.098, p < 0.05). Conclusions: PP13 assayed in amniotic fluid might be a potential marker of fetal growth, and sHLA-G can be an adjunct modality reflecting placental sonographic parameters.
Post-Traumatic Cerebral Infarction: A Narrative Review of Pathophysiology, Diagnosis, and Treatment
Authors: Poblete Roy A. , Zhong Charlotte , Patel Anish , Kuo Grace , Sun Philip Y. , Xiao Jiayu , Fan Zhaoyang , Sanossian Nerses , Towfighi Amytis , Lyden Patrick D.
Published: January 2024

Traumatic brain injury (TBI) is a common diagnosis requiring acute hospitalization. Long-term, TBI is a significant source of health and socioeconomic impact in the United States and globally. The goal of clinicians who manage TBI is to prevent secondary brain injury. In this population, post-traumatic cerebral infarction (PTCI) acutely after TBI is an important but under-recognized complication that is associated with negative functional outcomes. In this comprehensive review, we describe the incidence and pathophysiology of PTCI. We then discuss the diagnostic and treatment approaches for the most common etiologies of isolated PTCI, including brain herniation syndromes, cervical artery dissection, venous thrombosis, and post-traumatic vasospasm. In addition to these mechanisms, hypercoagulability and microcirculatory failure can also exacerbate ischemia. We aim to highlight the importance of this condition and future clinical research needs with the goal of improving patient outcomes after TBI.
Obesity-Resistant Mice on a High-Fat Diet Display a Distinct Phenotype Linked to Enhanced Lipid Metabolism
Authors: Milhem Fadia , Skates Emily , Wilson Mickey , Komarnytsky Slavko
Published: January 2024

Individually, metabolic variations can significantly influence predisposition to obesity in the form of the obesity-prone (super-responders) and obesity-resistant (non-responders) phenotypes in response to modern calorie-dense diets. In this study, C57BL/6J mice (n = 76) were randomly assigned to either a low-fat diet (LFD) or a high-fat diet (HFD) for 6 weeks, followed by selection of the normally obese (HFD), non-responders (NR), super-responders (SR), or super-responders switched back to the low-fat diet (SR-LFD) for an additional 8 weeks. SR mice showed the highest gains in body weight, lean and fat body mass, and total and free water, in part due to increased feed efficiency, despite having a respiratory exchange ratio (RER) similar to that of NR mice. A switch to the LFD was sufficient to revert most of the observed physiological changes in the SR-LFD mice; however, voluntary physical activity and exercise capacity did not return to the basal level. NR mice showed the highest food intake, lowest feed efficiency, increased oxygen consumption during the light (rest) cycle, increased physical activity during the dark (active) cycle, and increased heat production during both cycles. These variations were observed in the absence of changes in food intake and fecal parameters; however, NR fecal lipid content was lower, and the NR fecal microbiome profile was characterized by reduced abundance of Actinobacteria. Taken together, our findings suggest that NR mice showed an increased ability to metabolize excessive dietary fats in skeletal muscle at the expense of reduced exercise capacity that persisted for the duration of the study. These findings underscore the need for further comprehensive investigations into the mechanisms of obesity resistance, as they hold potential implications for weight-loss strategies in human subjects.
Nutrition and Disorders of Gut–Brain Interaction
Authors: Scarpellini Emidio , Balsiger Lukas Michaja , Broeders Bert , Houte Karen Van Den , Routhiaux Karen , Raymenants Karlien , Carbone Florencia , Tack Jan
Published: January 2024

Background: Disorders of gut–brain interaction (DGBIs) have a complex pathophysiology that is often characterized by a relationship between food ingestion and triggering of symptoms. Understanding of the underlying mechanisms and the role of nutrients as a therapeutic target are rapidly evolving. Aims and methods: We performed a narrative review of the literature using the following keywords, their acronyms, and their associations: nutrients, disorders of gut–brain interaction; functional dyspepsia; malabsorption; irritable bowel syndrome; diarrhea; constipation. Results: Functional dyspepsia displayed a significant correlation between volume, fat and/or wheat abundance, chemical composition of ingested food and symptoms of early satiety, fullness and weight loss. Carbohydrate malabsorption is related to enzyme deficiency throughout the GI tract. Food composition and richness in soluble vs. non-soluble fibers is related to constipation and diarrhea. The elimination of fermentable oligo-, di-, monosaccharides and polyols (FODMAPs) has a significant and non-unidirectional impact on irritable bowel syndrome (IBS) symptoms. Conclusions: Food volume, nutritive and chemical composition, and its malabsorption are associated with symptom generation in DGBIs. Further multicenter, randomized-controlled clinical trials are needed to clarify the underlying pathophysiology.
Prevalence and Risk Factors of Eimeria spp. in Broiler Chickens from Pichincha and Santo Domingo de los Tsáchilas, Ecuador
Authors: Cevallos-Gordon Ana , Molina C. Alfonso , Radman Nilda , Ron Lenin , Gamboa María Ines
Published: January 2024

Coccidiosis in chickens is a parasitic disease of economic importance for the poultry industry. In Ecuador, there is limited information regarding the prevalence of Eimeria spp. on commercial broiler farms. Therefore, a total of 155 poultry farms in the provinces of Pichincha and Santo Domingo de los Tsáchilas were surveyed. The analysis of fresh fecal samples was conducted to determine the parasitic load of six of the seven chicken Eimeria species (excluding E. mitis) through multiplex PCR. Additionally, an epidemiological survey was performed to assess the risk factors associated with the infection using a multivariable logistic regression model. All samples tested positive for the presence of Eimeria spp., despite the farmers having implemented prophylactic measures, and no clinical coccidiosis cases were recorded. The parasitic load varied between 25 and 69,900 oocyst per gram. The species prevalence was as follows: Eimeria spp. 100%, E. maxima 80.4%, E. acervulina 70.6%, E. praecox 55.4%, E. tenella 53.6%, E. necatrix 52.2%, and E. brunetti 30.8%. The main species combination was E. cervuline, E. maxima, E. necatrix, and E. praecox (23.90%), followed by E. tenella, as a unique species (10.69%), and then E. acervulina, E. maxima, and E. praecox (8.81%). It was observed that farms operated by independent producers had a higher amount of Eimeria spp. and higher probability of the presence of E. brunetti, E. necatrix, E. praecox, and E. tenella. Poultry houses located below 1300 m above sea level were associated with a higher parasitic load and the presence of E. brunetti. Birds younger than 35 days of age and from open-sided poultry houses (with rudimentary environmental control) had a higher probability of presenting E. maxima. Drinking water from wells increased the risk of E. praecox presence. Research aimed at designing control strategies to improve health management on poultry farms in the region would help minimize the impact of coccidiosis.
Chemical Modification of Cytochrome C for Acid-Responsive Intracellular Apoptotic Protein Delivery for Cancer Eradication
Authors: Tang Bo , Lau Kwai Man , Zhu Yunxin , Shao Chihao , Wong Wai-Ting , Chow Larry M. C. , Wong Clarence T. T.
Published: January 2024

Delivering bioactive proteins into cells without carriers presents significant challenges in biomedical applications due to limited cell membrane permeability and the need for targeted delivery. Here, we introduce a novel carrier-free method that addresses these challenges by chemically modifying proteins with an acid-responsive cell-penetrating peptide (CPP) for selective intracellular delivery within tumours. Cytochrome C, a protein known for inducing apoptosis, served as a model for intracellular delivery of therapeutic proteins for cancer treatment. The CPP was protected with 2,3-dimethyl maleic anhydride (DMA) and chemically conjugated onto the protein surface, creating an acid-responsive protein delivery system. In the acidic tumour microenvironment, DMA deprotects and exposes the positively charged CPP, enabling membrane penetration. Both in vitro and in vivo assays validated the pH-dependent shielding mechanism, demonstrating the modified cytochrome C could induce apoptosis in cancer cells in a pH-selective manner. These findings provide a promising new approach for carrier-free and tumour-targeted intracellular delivery of therapeutic proteins for a wide range of potential applications.
Hawaiian Treeline Ecotones: Implications for Plant Community Conservation under Climate Change
Authors: Ainsworth Alison , Drake Donald R.
Published: January 2024

Species within tropical alpine treeline ecotones are predicted to be especially sensitive to climate variability because this zone represents tree species’ altitudinal limits. Hawaiian volcanoes have distinct treeline ecotones driven by trade wind inversions. The local climate is changing, but little is known about how this influences treeline vegetation. To predict future impacts of climate variability on treelines, we must define the range of variation in treeline ecotone characteristics. Previous studies highlighted an abrupt transition between subalpine grasslands and wet forest on windward Haleakalā, but this site does not represent the diversity of treeline ecotones among volcanoes, lava substrates, and local climatic conditions. To capture this diversity, we used data from 225 plots spanning treelines (1500–2500 m) on Haleakalā and Mauna Loa to characterize ecotonal plant communities. Treeline indicator species differ by moisture and temperature, with common native species important for wet forest, subalpine woodland, and subalpine shrubland. The frequency or abundance of community indicator species may be better predictors of shifting local climates than the presence or absence of tree life forms per se. This study further supports the hypothesis that changes in available moisture, rather than temperature, will dictate the future trajectory of Hawaiian treeline ecotone communities.
A Novel Recyclable Magnetic Nano-Catalyst for Fenton-Photodegradation of Methyl Orange and Imidazole Derivatives Catalytic Synthesis
Authors: Albalawi Marzough A. , Hajri Amira K. , Jamoussi Bassem , Albalawi Omnia A.
Published: January 2024

A magnetite chlorodeoxycellulose/ferroferric oxide (CDC@Fe3O4) heterogeneous photocatalyst was synthesised via treated and modified cotton in two steps. The designed nanocomposites were characterised by FTIR, TGA, XRD, SEM, and VSM analyses. The Fenton-photocatalytic decomposition efficiency of the synthesised magnetic catalyst was evaluated under visible sunlight using Methyl Orange (MO) as a model organic pollutant. The impacts of several degradation parameters, including the light source, catalyst load, irradiation temperature, oxidant dose, and pH of the dye aqueous solution and its corresponding concentration on the Fenton photodegradation performance, were methodically investigated. The (CDC@Fe3O4) heterogeneous catalyst showed a remarkable MO removal rate of 97.9% at 10 min under visible-light irradiation. (CDC@Fe3O4) nanomaterials were also used in a heterogeneous catalytic optimised protocol for a multicomponent reaction procedure to obtain nine tetra-substituted imidazole derivatives. The green protocol afforded imidazole derivatives in 30 min with good yields (91–97%) at room temperature and under ultrasound irradiation. Generally, a synthesised recyclable heterogeneous nano-catalyst is a good example and is suitable for wastewater treatment and organic synthesis.
Theoretical and Experimental Research Concerning the Friction Forces Developed in Hydraulic Cylinder Coaxial Sealing Systems Made from Polymers
Authors: Sârbu Flavius Aurelian , Arnăuţ Felix , Deaconescu Andrea , Deaconescu Tudor
Published: January 2024

Optimizing the energy efficiency of hydraulic cylinder modern sealing systems requires, among other things, minimizing the developed friction forces. This can be achieved by manufacturing seals from polymer-based polytetrafluoroethylene-type materials (Virgin PTFE and filled PTFE) or from thermoplastic polyurethane elastomers. This paper presents a procedure for calculating and experimentally determining the friction forces developed in the coaxial sealing systems of hydraulic cylinders pistons. Three sealing systems made from different materials were tested under varying conditions of pressure and velocity on an experimental test stand set up by the authors. The paper concludes with data and recommendations for the selection of the optimum seal material in order to maximize energy efficiency. Our comparative research conducted on the seal materials led to the conclusion that for reducing friction forces in hydraulic cylinders, Virgin PTFE is the most adequate.
Prediction Models of Mechanical Properties of Jute/PLA Composite Based on X-ray Computed Tomography
Authors: Zhao Xintao , Li Junteng , Su Shangbin , Jiang Ning
Published: January 2024

The tensile strength and modulus of elasticity of a jute/polylactic acid (PLA) composite were found to vary nonlinearly with the loading angle of the specimen through the tensile test. The variation in these properties was related to the fiber orientation distribution (FOD) and fiber length distribution (FLD). In order to study the effects of the FOD and FLD of short fibers on the mechanical properties and to better predict the mechanical properties of short-fiber composites, the true distribution of short fibers in the composite was accurately obtained using X-ray computed tomography (XCT), in which about 70% of the jute fibers were less than 300 μm in length and the fibers were mainly distributed along the direction of mold flow. The probability density functions of the FOD and FLD were obtained by further analyzing the XCT data. Strength and elastic modulus prediction models applicable to short-fiber-reinforced polymer (SFRP) composites were created by modifying the laminate theory and the rule of mixtures using the probability density functions of the FOD and FLD. The experimental measurements were in good agreement with the model predictions.
Effect of Direct-Contact Ultrasonic and Far Infrared Combined Drying on the Drying Characteristics and Quality of Ginger
Authors: Feng Zhenhua , Zhang Minmin , Guo Lanping , Shao Rencai , Wang Xiao , Liu Feng
Published: January 2024

In this study, the effects of ultrasonic power, drying temperature, and slice thickness on the drying rate, chromatism, water migration law, gingerol content, flavor, and antioxidant activity of ginger were investigated by using a direct-contact ultrasound and far infrared combined drying technology. The results showed that compared with single far infrared drying, direct-contact ultrasound and far infrared combined drying accelerated the free water migration rate of ginger (7.1~38.1%), shortened the drying time (from 280 min to 160 min), reduced the loss of volatile components in ginger, and significantly increased the antioxidant activity of ginger (p < 0.05). Furthermore, after ultrasound intervention, the gingerol content decreased in slices of 4 mm thickness (0.1226 ± 0.0189 mg/g to 0.1177 ± 0.0837 mg/g) but increased in slices of 6 mm thickness (0.1104 ± 0.0162 mg/g to 0.1268 ± 0.0112 mg/g). This drying technology has a certain reference significance for the drying process of ginger slices.
Design and Characterization of a Melt Electrostatic Precipitator for Advanced Drug Formulations
Authors: Justen Anna , Weltersbach Alina Faye , Schaldach Gerhard , Thommes Markus
Published: January 2024

Electrostatic precipitators (ESP) are especially known for the efficient separation of micron and submicron particles from aerosols. Wet electrostatic precipitators are particularly suitable for highly resistive materials. Using these, particles can be directly transferred into a liquid for further processing or safer handling, which is advantageous for either hazardous or valuable materials. In this work, a wet ESP, which enables the separation of highly resistive particles into a heated liquid, was designed and investigated. To do this, spray-dried drug particles were embedded in a molten sugar alcohol to enhance the drug dissolution rate. After cooling, the solidified product showed advantageous properties such as a high drug dissolution rate and easy handling for further processing. For the design of the wet ESP, different discharge electrode configurations were tested. A wall film served as the collection electrode, which was generated by a specially designed distributer die. A laminar flow regime was achieved with a homogeneous film serving as the collection electrode, which is particularly important for a high separation efficiency. A prototype was designed and constructed in this respect. The particle separation into hot liquids or onto hot surfaces is challenging due to thermal effects in ESPs. The influence of thermophoresis and drag force on the particle transport was investigated, and optimum operation parameters were found for the present ESP. A broad field of applications can be covered with the presented device, where particles are embedded in even hot liquids to form liquid suspensions or, as it is presented here, solid dispersions. The dissolution of the drug-containing solid dispersion was studied in vitro. A remarkably faster drug dissolution was observed from the solid dispersion, as compared to a powder mixture of the drug and xylitol.
Design and Implementation of High-Efficiency and Compact Fuel Cell–Battery Hybrid Power System
Authors: Chen Yu-Kai , Wu Min-Min , Hsiao Chung-En , Hsu Che-Jung , Lin Cheng-Huei , Shih Yen-Teh
Published: January 2024

This paper proposes a high-efficiency and compact fuel cell–battery hybrid power system without DC/DC converters. Generally, fuel cells supply power to charge lithium batteries or loads using DC/DC converters. The disadvantages of a DC/DC converter are its complex design, poor efficiency, and large volume. Therefore, improvements in the volume, weight, and efficiency are the main objectives of the proposed topology, which is suitable for stable operation in power equipment. This paper proposes a novel topology without DC/DC converters for a fuel cell–battery hybrid forklift system and analyzes, discusses, and verifies it with experimental measurements. Additionally, the proposed topology uses an average charging method to charge the Li-ion battery. The dynamic response of fuel cells is slower than that of Li-ion batteries. By properly configuring the voltages of a fuel cell and a lithium battery, we propose a hybrid system that can maintain a stable output and high efficiency in different operating modes without DC/DC converters. Detailed efficiency calculations and comparisons reveal that the method proposed in this paper achieves an efficiency increase of 5.36% compared with traditional approaches, while maintaining a set charging current. The proposed topology and charging method are verified with experiments on a 10 kW fuel cell–battery system, and the results indicate that the proposed method without DC/DC converters is more suitable for hybrid applications than traditional methods. The proposed system achieves optimal efficiency of 98.27%, surpassing the performance of a traditional hybrid system employing regulated DC/DC converters. Additionally, the system incorporates a mechanism to achieve constant current control, ensuring precise control over the desired charging current. The error in the desired charging current, determined through the average charging method, is 5%.
Study on the Extraction Mechanism of Metal Ions on Small Molecular Phase of Tar-Rich Coal under Ultrasonic Loading
Authors: Wang Zetang , Bao Yuan , Wang Chaoyong , Hu Yiliang
Published: January 2024

This study aims to elucidate the mechanism by which the ultrasonic loading of metal affects the extraction of small molecular phase substances (low molecular compounds) in tar-rich coal. Tar-rich coal samples were collected from the Huangling mining area in the southeastern Ordos Basin, China. The coal, the leaching solution of the coal, the extraction products, and the extraction residual coal samples with different metal ions loaded by ultrasound were analyzed using field emission scanning electron microscopy, pH detection, gas chromatography–mass spectrometry, a Fourier transform infrared spectrometer, and an X-ray diffractometer. The obtained results indicated that the ultrasonic loading of coal samples with different metal ions (Mn2+, Co2+, Cu2+, Fe2+, and Ni2+) promoted the extraction of small molecular phase substances in coal and increased the proportion of extracted aliphatic hydrocarbons, alkylbenzene, naphthalene, phenanthrene, and other compounds. The extraction rate of Mn2+ was the highest. Compared with the control group, the extraction rate was increased by 212%. After the ultrasonic loading of metal ions, the physical structure of the coal was loose and the contact area of the solvent increased; the degree of branching and the hydrogen enrichment of the residual coal decreased, the aromaticity increased, the interlayer spacing and stacking layers decreased, and the stacking degree and ductility increased. Metal ions exchanged with hydrogen ions in the coal molecules. At the same time, the metal ions were adsorbed in the coal molecules and effectively combined with free electrons in the coal molecules to catalyze; thus, the extraction effect of the small molecular phase of tar-rich coal was improved. This provides a new method for the clean and efficient utilization of tar-rich coal.
Research on Inversion Log Evaluation Method of Special Mineral in Alkali Lake Shale Oil Reservoir—A Case Study of the Fengcheng Formation in the Mahu Sag, China
Authors: Zhao Lei , Mao Rui , Deng Xili , Feng Ziyan , Chen Junkai , Zong Xianghua , Feng Cheng
Published: January 2024

The Fengcheng Formation in the Mahu Sag of the Junggar Basin, China, is characterized by alkaline lake deposits, featuring abundant alkaline minerals. The content of alkaline minerals affects the physical properties and oil-bearing properties of the reservoir, and existing mineral inversion methods cannot calculate the content of alkaline minerals. Based on Litho Scanner Log data, we can calculate the dry weight of elements using the oxide closure model. By improving the rock volume physical model; adding trona, shortite, eitelite, and reedmergnerite to the rock volume physical model; and combining with the least squares method, the mineral content calculation was carried out, using the inversion method of combination models (Shortite Model, Eitelite Model, Reedmergnerite Model, and Trona Model) to achieve mineral inversion of alkali-bearing shale oil reservoirs. Litho Scanner Log is expensive, and its widespread application will increase exploration costs. This article scales the mineral inversion results of Litho Scanner Log into conventional log data, improves the rock volume physical model of conventional log, and uses a combination model to achieve mineral inversion of alkali-bearing shale oil reservoirs in conventional log. Compared with the results of X-ray diffraction experiments, the average absolute error of all minerals except for trona and feldspar is less than 10%, and the inversion results are consistent with the core test results. The research results of this article can provide theoretical and technical support for the log evaluation of alkali-bearing shale oil reservoirs.
Process Path for Reducing Carbon Emissions from Steel Industry—Combined Electrification and Hydrogen Reduction
Authors: Sun Caijiao , Wang Jie , Zhou Meijie , Hong Lukuo , Ai Liqun , Wen Li
Published: January 2024

This review focuses on the energy structure of iron and steel production and a feasible development path for carbon reduction. The process path and feasible development direction of carbon emission reduction in the iron and steel industry have been analyzed from the perspective of the carbon–electricity–hydrogen ternary relationship. Frontier technologies such as “hydrogen replacing carbon” are being developed worldwide. Combining the high efficiency of microwave electric-thermal conversion with the high efficiency and pollution-free advantages of hydrogen-reducing agents may drive future developments. In this review, a process path for “microwave + hydrogen” synergistic metallurgy is proposed. The reduction of magnetite powder by H2 (CO) in a microwave field versus in a conventional field is compared. The driving effect of the microwave field is found to be significant, and the synergistic reduction effect of microwaves with H2 is far greater than that of CO.
Charismatic Embeddedness: A Cultural Starting Mechanism Generating Relational Goods in an Interreligious Field. An Analysis from Algeria
Authors: Paglione M. Licia , Luppi Marco
Published: January 2024

This article, entering into the debate on the influence of cultural factors on social action, highlights how a charismatic inspiration, as part of religious culture, could represent a relevant element in social phenomena. In particular, this article proposes an analysis of the role of a specific charismatic inspiration, in relation to the spirituality of the Focolare Movement (FM), in the interreligious field thanks to the “embeddedness” of the social action of its members of different religions in a specific charismatic culture. The analysis aims to understand whether and how this mechanism works by observing a specific Catholic–Muslim phenomenon developed in Algeria since 1966, using an interdisciplinary perspective between sociology and history and the case-study strategy, discovering that what we define as “charismatic embeddedness” could work as a “starting mechanism” generating “interreligious relational goods”.
Evaluation of a Voice-Enabled Autonomous Camera Control System for the da Vinci Surgical Robot
Authors: Paul Reenu Arikkat , Jawad Luay , Shankar Abhishek , Majumdar Maitreyee , Herrick-Thomason Troy , Pandya Abhilash
Published: January 2024

Robotic surgery involves significant task switching between tool control and camera control, which can be a source of distraction and error. This study evaluated the performance of a voice-enabled autonomous camera control system compared to a human-operated camera for the da Vinci surgical robot. Twenty subjects performed a series of tasks that required them to instruct the camera to move to specific locations to complete the tasks. The subjects performed the tasks (1) using an automated camera system that could be tailored based on keywords; and (2) directing a human camera operator using voice commands. The data were analyzed using task completion measures and the NASA Task Load Index (TLX) human performance metrics. The human-operated camera control method was able to outperform an automated algorithm in terms of task completion (6.96 vs. 7.71 correct insertions; p-value = 0.044). However, subjective feedback suggests that a voice-enabled autonomous camera control system is comparable to a human-operated camera control system. Based on the subjects’ feedback, thirteen out of the twenty subjects preferred the voice-enabled autonomous camera control system including the surgeon. This study is a step towards a more natural language interface for surgical robotics as these systems become better partners during surgery.