bluuebunny/crossref_metadata_2025 huggingface dataset:
A systematic review of the non-surgical treatment of Perthes’ disease
Authors: Galloway Adam M. , van-Hille Thomas , Perry Daniel C. , Holton Colin , Mason Laura , Richards Suzanne , Siddle Heidi J. , Comer Christine
Published: December 2020

Aims

Perthes’ disease is a condition leading to necrosis of the femoral head. It is most common in children aged four to nine years, affecting around one per 1,200 children in the UK. Management typically includes non-surgical treatment options, such as physiotherapy with/without surgical intervention. However, there is significant variation in care with no consensus on the most effective treatment option.

Methods

This systematic review aims to evaluate the effectiveness of non-surgical interventions for the treatment of Perthes’ disease. Comparative studies (experimental or observational) of any non-surgical intervention compared directly with any alternative intervention (surgical, non-surgical or no intervention) were identified from: Cochrane Central Register of Controlled Trials, MEDLINE, EMBASE, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), EMcare, Allied and Complementary Medicine Database (AMED), and the Physiotherapy Evidence Database (PEDro). Data were extracted on interventions compared and methodological quality. For post-intervention primary outcome of radiological scores (Stulberg and/or Mose), event rates for poor scores were calculated with significance values. Secondary outcomes included functional measures, such as range of movement, and patient-reported outcomes such as health-related quality of life.

Results

In all, 15 studies (1,745 participants) were eligible for inclusion: eight prospective cohort studies, seven retrospective cohort studies, and no randomized controlled trials were identified. Non-surgical interventions largely focused on orthotic management (14/15 studies) and physical interventions such as muscle strengthening or stretching (5/15 studies). Most studies were of high/unknown risk of bias, and the range of patient outcomes was very limited, as was reporting of treatment protocols. Similar proportions of children achieving poor radiological outcomes were found for orthotic management and physical interventions, such as physiotherapy or weightbearing alteration, compared with surgical interventions or no intervention.

Conclusion

Evidence from non-randomized studies found no robust evidence regarding the most effective non-surgical interventions for the treatment of children with Perthes’ disease. Future research, employing randomized trial designs, and reporting a wider range of patient outcomes is urgently needed to inform clinical practice. Cite this article: Bone Jt Open 2020;1-12:720–730.
ClipKIT: A multiple sequence alignment trimming software for accurate phylogenomic inference
Authors: Steenwyk Jacob L. , Buida Thomas J. , Li Yuanning , Shen Xing-Xing , Rokas Antonis
Published: December 2020

Highly divergent sites in multiple sequence alignments (MSAs), which can stem from erroneous inference of homology and saturation of substitutions, are thought to negatively impact phylogenetic inference. Thus, several different trimming strategies have been developed for identifying and removing these sites prior to phylogenetic inference. However, a recent study reported that doing so can worsen inference, underscoring the need for alternative alignment trimming strategies. Here, we introduce ClipKIT, an alignment trimming software that, rather than identifying and removing putatively phylogenetically uninformative sites, instead aims to identify and retain parsimony-informative sites, which are known to be phylogenetically informative. To test the efficacy of ClipKIT, we examined the accuracy and support of phylogenies inferred from 14 different alignment trimming strategies, including those implemented in ClipKIT, across nearly 140,000 alignments from a broad sampling of evolutionary histories. Phylogenies inferred from ClipKIT-trimmed alignments are accurate, robust, and time saving. Furthermore, ClipKIT consistently outperformed other trimming methods across diverse datasets, suggesting that strategies based on identifying and retaining parsimony-informative sites provide a robust framework for alignment trimming.
Orientation processing by synaptic integration across first-order tactile neurons
Authors: Hay Etay , Pruszynski J. Andrew
Published: December 2020

Our ability to manipulate objects relies on tactile inputs from first-order tactile neurons that innervate the glabrous skin of the hand. The distal axon of these neurons branches in the skin and innervates many mechanoreceptors, yielding spatially-complex receptive fields. Here we show that synaptic integration across the complex signals from the first-order neuronal population could underlie human ability to accurately (< 3°) and rapidly process the orientation of edges moving across the fingertip. We first derive spiking models of human first-order tactile neurons that fit and predict responses to moving edges with high accuracy. We then use the model neurons in simulating the peripheral neuronal population that innervates a fingertip. We train classifiers performing synaptic integration across the neuronal population activity, and show that synaptic integration across first-order neurons can process edge orientations with high acuity and speed. In particular, our models suggest that integration of fast-decaying (AMPA-like) synaptic inputs within short timescales is critical for discriminating fine orientations, whereas integration of slow-decaying (NMDA-like) synaptic inputs supports discrimination of coarser orientations and maintains robustness over longer timescales. Taken together, our results provide new insight into the computations occurring in the earliest stages of the human tactile processing pathway and how they may be critical for supporting hand function.
Genome-wide identification of major genes and genomic prediction using high-density and text-mined gene-based SNP panels in Hanwoo (Korean cattle)
Authors: Lee Hyo Jun , Chung Yoon Ji , Jang Sungbong , Seo Dong Won , Lee Hak Kyo , Yoon Duhak , Lim Dajeong , Lee Seung Hwan
Published: December 2020

It was hypothesized that single-nucleotide polymorphisms (SNPs) extracted from text-mined genes could be more tightly related to causal variant for each trait and that differentially weighting of this SNP panel in the GBLUP model could improve the performance of genomic prediction in cattle. Fitting two GRMs constructed by text-mined SNPs and SNPs except text-mined SNPs from 777k SNPs set (exp_777K) as different random effects showed better accuracy than fitting one GRM (Im_777K) for six traits (e.g. backfat thickness: + 0.002, eye muscle area: + 0.014, Warner–Bratzler Shear Force ofsemimembranosusandlongissimus dorsi: + 0.024 and + 0.068, intramuscular fat content ofsemimembranosusandlongissimus dorsi: + 0.008 and + 0.018). These results can suggest that attempts to incorporate text mining into genomic predictions seem valuable, and further study using text mining can be expected to present the significant results.
Profile of sexually transmitted infections causing urethritis and a related inflammatory reaction in urine among heterosexual males: A flow-cytometry study
Authors: Tjagur Stanislav , Mändar Reet , Punab Margus
Published: December 2020

Background

Information about the use of flow cytometry in the diagnosis of male urethritis is scarce. The current study aims to evaluate the performance of flow cytometry on first-voided urine in males with infectious urethritis (Chlamydia trachomatis,Neisseria gonorrhoeae,Mycoplasma genitaliumandTrichomonas vaginalis).

Methods

Male patients of the Andrology Centre (Tartu University Hospital, Estonia) were recruited during the period March 2015 –January 2018. Cases included 306 patients with infectious urethritis caused byChlamydia trachomatis,Neisseria gonorrhoeae,Mycoplasma genitaliumand/orTrichomonas vaginalis. The control group consisted of 192 patients without uro-genital complaints, negative tests forC.trachomatis,N.gonorrhoeae,M.genitaliumandT.vaginalisfrom first-voided urine and no inflammation in first-voided urine, mid-stream urine and urine after prostate massage.C.trachomatis,N.gonorrhoeae,M.genitaliumandT.vaginaliswere detected from first-voided urine using polymerase chain reaction (PCR) method. First-voided urine was analysed using urine particle analyzer Sysmex UF-500i.

Results

The most prevalent infection was chlamydia (64.1%), followed byMycoplasma genitalium(20.9%), gonorrhoea (7.8%) and trichomoniasis (1.6%). Gonorrhoea caused the highest flow-cytometric leucocyte/bacteria count, followed by chlamydia andMycoplasma genitalium.Trichomonas vaginalisshowed nearly absent inflammation in first-voided urine. Using an empiric flow-cytometry diagnostic threshold for urethritis in first-voided urine (leucocytes ≥ 15/μl and bacteria ≥ 20/μl) the total calculated sensitivity was over 90%. However, when applying such criteria for deciding whether to perform first-voided urine PCR forC.trachomatis,N.gonorrhoeae,M.genitaliumandT.vaginalisor not, we could miss 23 cases with infectious urethritis that makes up 7,5% of all proven cases.

Conclusions

Flow cytometry of first-voided urine can be considered as a rapid and objective screening method in case of suspected male infectious urethritis.
Pediatric health-related quality of life and school social capital through network perspectives
Authors: Hirota Tomoya , Takahashi Michio , Adachi Masaki , Nakamura Kazuhiko
Published: December 2020

Background

Despite their importance in population health among children and adolescents, our understanding of how individual items mutually interact within and between pediatric health-related quality of life (HRQOL) and school social capital is limited.

Methods

We employed network analysis in a general population sample of 7759 children aged 9–15 years to explore the network structure of relations among pediatric HRQOL and school social capital items measured using validated scales. Furthermore, network centrality was examined to identify central items that had stronger and more direct connections with other items in the network than others. Network structure and overall strength of connectivity among items were compared between groups (by sex and age).

Results

Our analysis revealed that the item related to school/academic functioning and the item related to shared enjoyment among students had the highest strength centrality in the network of HRQOL and school social capital, respectively, underpinning their critical roles in pediatric HRQOL and school social capital. Additionally, the edge connecting “I trust my friends at school” and “trouble getting along with peers” had the strongest negative edge weight among ones connecting school social capital and pediatric HRQOL constructs. Network comparison test revealed stronger overall network connectivity in middle schoolers compared to elementary schoolers but no differences between male and female students.

Conclusion

The network approach elucidated the complex relationship of mutually influencing items within and between pediatric HRQOL and school social capital. Addressing central items may promote children’s perceived health and school social capital.
The association between osteopontin and tuberculosis: A systematic review and meta-analysis
Authors: Wang Dongguang , Tong Xiang , Wang Lian , Zhang Shijie , Huang Jizhen , Zhang Li , Fan Hong
Published: December 2020

Objective

We examined the data reported in the studies for comparison of osteopontin (OPN) levels in tuberculosis and healthy participants, and to discuss whether OPN could be extended to disease diagnosis, severity assessment and therapeutic effect monitering.

Methods

A systematic literature search was conducted in PubMed, EMBASE, Scopus, the Cochrane Library, Web of Science, the China National Knowledge Infrastructure (CNKI) and WanFang databases. The pooled risk estimates were shown in standardized mean difference (SMD) with 95% confidence interval (CI) for OPN levels. The random effect model was used according to the test of heterogeneity among studies. Subgroup analyses and meta-regression models were performed to identify the possible sources of heterogeneity.

Results

17 retrospective studies with 933 tuberculosis participants and 786 healthy controls were finally included in this article. In the primary meta-analysis, higher serum/plasma OPN levels were found in tuberculosis patients (SMD = 2.58, 95%CI = 2.09~3.08,P<0.001). Besides, pooled results from positive acid-fast bacilli (AFB) staining and imaging-severe tuberculosis group demonstrated higher OPN concentrations (SMD = 0.90, 95%CI = 0.58~1.21,P<0.001; SMD = 1.11, 95%CI = 0.90~1.33,P<0.001; respectively), and OPN levels decreased after two months of standard anti-tuberculosis therapy (SMD = 2.10, 95%CI = 1.36~2.85,P<0.001).

Conclusions

Elevated serum/plasma OPN levels may be associated with an increased risk of tuberculosis, while further well-designed studies are needed. Moreover, OPN could be considered as a potential biomarker for tuberculosis surveillance and severity assessment.
Interference control in working memory: Evidence for discriminant validity between removal and inhibition tasks
Authors: Rey-Mermet Alodie , Singh Krishneil A. , Gignac Gilles E. , Brydges Christopher R. , Ecker Ullrich K. H.
Published: December 2020

Working memory (WM) is a system for maintenance of and access to a limited number of goal-relevant representations in the service of higher cognition. Because of its limited capacity, WM requires interference-control processes, allowing us to avoid being distracted by irrelevant information. Recent research has proposed two interference-control processes, which are conceptually similar: (1) an active, item-wise removal process assumed to remove no-longer relevant information from WM, and (2) an inhibitory process assumed to suppress the activation of distractors against competing, goal-relevant representations. The purpose of this study was to determine the extent to which the tasks used to assess removal and inhibition measure the same interference-control construct. Results showed acceptable to good reliabilities for nearly all measures. Similar to previous studies, a structural equation modeling approach identified a reliable latent variable of removal. However, also similar to some previous studies, no latent variable of inhibition could be established. This was the case even when the correlation matrix used to compute the latent variable of inhibition was disattenuated for imperfect reliability. Critically, the individual measures of inhibition were unrelated to the latent variable of removal. These results provide tentative support for the notion that removal is not related to the interference-control processes assessed in inhibition tasks. This suggests that the removal process should be conceptualized as a process independent of the concept of inhibition, as proposed in computational WM models that implement removal as the “unbinding” of a WM item from the context in which it occurred.
Mortality in rheumatoid arthritis patients with pulmonary nontuberculous mycobacterial disease: A retrospective cohort study
Authors: Mori Shunsuke , Koga Yukinori , Nakamura Kazuyoshi , Hirooka Sayuri , Matsuoka Takako , Uramoto Hideshi , Sakamoto Osamu , Ueki Yukitaka
Published: December 2020

Objective

The aim of this study was to compare long-term mortality following diagnosis of pulmonary nontuberculous mycobacterial (NTM) disease between patients with and without rheumatoid arthritis (RA) and to evaluate predictive factors for death outcomes.

Methods

We reviewed the electronic medical records of all patients who were newly diagnosed with pulmonary NTM disease at participating institutions between August 2009 and December 2018. Patients were followed until death, loss to follow-up, or the end of the study. Taking into consideration the presence of competing risks, we used the cumulative incidence function with Gray’s test and Fine-Gray regression analysis for survival analysis.

Results

A total of 225 patients (34 RA patients and 191 non-RA controls) were followed, with a mean time of 47.5 months. Death occurred in 35.3% of RA patients and 25.7% of non-RA patients. An exacerbation of pulmonary NTM disease represented the major cause of death. The estimated cumulative incidence of all-cause death at 5 years was 24% for RA patients and 23% for non-RA patients. For NTM-related death, the 5-year cumulative incidence rate was estimated to be 11% for RA patients and 18% for non-RA patients. Gray’s test revealed that long-term mortality estimates were not significantly different between patient groups. Fine-Gray regression analysis showed that the predictive factors for NTM-related death were advanced age (adjusted hazards ratio 7.28 [95% confidence interval 2.91–18.20] for ≥80 years and 3.68 [1.46–9.26] for 70–80 years vs. <70 years), male sex (2.40 [1.29–4.45]), Mycobacterium abscessus complex (4.30 [1.46–12.69] vs. M. avium), and cavitary disease (4.08 [1.70–9.80]).

Conclusions

RA patients with pulmonary NTM disease were not at greater risk of long-term mortality compared with non-RA patients. Rather, advanced age, male sex, causative NTM species, and cavitary NTM disease should be considered when predicting the outcomes of RA patients with pulmonary NTM disease.
Zinc utilization and associated factors among under-five children with diarrhea in East Africa: A generalized linear mixed modeling
Authors: Yeshaw Yigizie , Worku Misganaw Gebrie , Tessema Zemenu Tadesse , Teshale Achamyeleh Birhanu , Tesema Getayeneh Antehunegn
Published: December 2020

Introduction

Diarrhea is the leading cause of illness and death among under-five children in low and middle income countries. Through the provision of zinc supplements has been shown to reduce the severity and duration of diarrhea, as well as the risk of mortality, the use of zinc for the treatment of diarrhea is still very low in low-income countries. Therefore, this study was conducted to determine the prevalence and associated factors of zinc utilization among under-five children with diarrhea in East Africa.

Methods

A secondary data analysis of the recent Demographic and Health Surveys (DHS) of East African countries were used to determine the prevalence and associated factors of zinc utilization among under-five children with diarrhea in East Africa. A total weighted samples of 16,875 under-five children with diarrhea were included in the study. A generalized linear mixed model (using Poisson regression with robust error variance) was used. Prevalence Ratios (PR) with their 95% confidence interval (CI) were calculated for those variables included in the final model.

Results

The overall prevalence of zinc utilization among under-five children with diarrhea in this study was 21.54% (95% CI = 20.92–22.16). Of East African countries, Uganda had the highest prevalence of zinc utilization (40.51%) whereas Comoros had the lowest (0.44%). Maternal primary education (Adjusted Prevalence Ratio(aPR) = 1.29, 95% CI: 1.16–1.44), secondary education (aPR = 1.36, 95% CI = 1.19–1.55) and higher education (aPR = 1.91, 95% CI = 1.52–2.40), high community women education (aPR = 1.12, 95% CI = 1.02–1.24), high wealth index (aPR = 1.12, 95% CI = 1.01–1.24), high community media exposure (aPR = 1.17, 95% CI = 1.06–1.29) were associated with a higher prevalence of zinc utilization.

Conclusion

The prevalence of zinc utilization among under-five children was found to be low in East Africa. Maternal education, wealth index, community women education, and community media exposure were significantly associated with zinc utilization. Increased mass media exposure, maternal education and wealth index is recommended to improve zinc utilization among under-five children with diarrhea.
Process drama in five international contexts: Considering emotional responses and dramatic structuring
Authors: Dunn Julie , Bundy Penny , Stinson Madonna
Published: December 2020

This article reports on the responses of 114 adult participants in a process drama delivered in five international contexts. Drawing upon the work of Gavin Bolton and key appraisal theorists, the aim of the article is to extend current understandings of how emotion is experienced within process drama, while also gaining new insights into the factors that impact its type and intensity. Using a framework that links emotion, connection and commitment, analysis of the data reveals that when individuals experience high levels of both commitment and connection, diverse emotions are generated. It also reveals that while these emotional responses are highly individual and generally independent of the strategies being employed, their intensity is associated with dramatic tension. The article suggests that an understanding of these findings is important for effective process drama structuring and facilitation.
Theatre-making and performance: The importance of authenticity in the process of ‘being’ and negotiating the ‘becoming’
Authors: Wong Jennifer , Bundy Penny
Published: December 2020

Theatre-making processes and performance opportunities offer young people who are vulnerable, marginalized or disenfranchised a means to rethink their current identities and consider different ways of being. This article discusses a three-month theatre-making programme with sixteen children from a low-income residential estate in Singapore. The programme, which culminated in two public performances, offered opportunities for the young people to re-engage with situations and experiences from their own lives. While exploration and story creation involved a fictional lens, the authors note the importance of including elements of authentic stories from the lives of participants. The theatre-making became a critical platform for the participants to examine the identities they performed; a state ofbeing, and offered ways for them to see how they could shape future identities for themselves through the process ofbecoming. It was also a physical and dialogical space providing young people in need of supportive structures in their lives with alternative perspectives and voices.
Multilingual realities/monolingual ideologies: Connecting the dots between schools’ language practices and international student well-being
Authors: Terruhn Jessica , Spoonley Paul
Published: December 2020

The globalization of the knowledge economy and a concomitant increase in educational mobility have seen greater numbers of international students take up studies in Aotearoa/New Zealand’s education system. As a result of increased educational mobility, alongside other types of migration, ethno-cultural and linguistic diversity has become more common in New Zealand schools. This internationalization of Aotearoa/New Zealand’s education sector has been met with government policies and strategies to ensure the well-being of international students. In these strategies, well-being is indicated by economic security, health and safety, as well as high-quality education and a welcoming and inclusive experience in Aotearoa/New Zealand. Drawing on data from a research project that examined how school policies and practices shape international English for speakers of other languages (ESOL) students’ sense of belonging, inclusion and well-being at a New Zealand secondary school, this article illuminates how school language practices impact on international students’ well-being. Specifically, the article highlights a profound mismatch between the diversification of the student body and the privileging of monolingual English-only practices in the classroom as well as the disparity between intentions and effects of the school’s pull-out ESOL class programme, in which ESOL-designated students are taught separately from ‘mainstream’ students. The discussion highlights the detrimental and discriminatory impacts such language practices had on international students. Based on this analysis, we argue that strategies that are designed to ensure international student well-being need to put greater emphasis on the instructional needs of culturally and linguistically diverse learners by advocating for linguistically responsive practices and that schools need to normalize multilingual practices to ensure international student well-being and to work towards equitable and just education.
USING THE CONCEPT OF TRANSACTION COSTS IN CAPITAL STRUCTURE MANAGEMENT
Authors: Lepeshkina Svetlana Viktorovna
Published: December 2020

The article discusses the theoretical aspects of issues related to the assessment of capital, the formation of its structure from the point of view of making management decisions in cost formation on its attraction and maintenance. The concept of “capital” is clarified from the point of view of its formation and subsequent efficiency assessment. The approach to the formation of capital structure concepts of the modern period on the development basis is justified. The method of estimating the cost of capital and the formation of the target capital structure, based on the inclusion of transaction costs in the cost of capital, which allows you to more accurately determine the size of these costs in relation to the amount of equity and more accurately generate the weighted average cost of capital of the organization. The empirical nature of the study allows us to use the proposed method of forming the capital structure in relation to various (individual) conditions of the organization’s functioning, followed by clarification of the parameters of decision-making based on the set goals of the organization’s activities.
ON THE BASIC DIRECTIONS OF IMPROVING STATE AND MUNICIPAL POLICIES IN THE FIELD OF MANAGEMENT OF THE TRANSPORT COMPLEX OF THE TERRITORY (ON MATERIALS OF THE ALTAI REGION)
Authors: Lyakisheva Valentina Grigoryevna , Voronkova Victoria Alexandrovna , Saghatelyan Venera Romanovna
Published: December 2020

The state of the transport complex of the municipality is one of the significant indicators of the level of socio­economic development of the territory. Important criteria for the effectiveness of managing this sector were the degree of development of public passenger transport, problems and prospects for improving this industry.The authors analyzed some elements of the city public transport management system in a number of municipalities of the Altai Territory, including as part of inter-municipal cooperation, and studied the opinion of residents on the issue under study.The relevance of the topic is emphasized by the ongoing national project, its federal and regional components, programs aimed at improving the industry and considered as instruments of regional and municipal policies in the field of managing the transport complex of territories.
DEMOGRAPHIC LIMITATIONS OF SUSTAINABLE DEVELOPMENT OF AGRICULTURAL REGIONS
Authors: Rodionova Lyudmila Vasilievna
Published: December 2020

The article discusses the features of the demographic development of agro-industrial regions in 1997-2018 against the background of Russia. Their intra-group differences were identified and measured, the relationship between the population and the economy, between demographic growth and socio-economic is described. The risks of population decline for sustainable development of agro-industrial regions are identified. Based on the analysis of demographic and socio-economic statistics, it is shown that depopulation processes in the agro-industrial regions are less intensive compared to the average Russian region, and in some of them population growth was observed. In terms of population, these regions are characterized by significant intra-group differentiation, which decreases over time. There is a positive statistically significant relationship between the demographic and socio­economic potential of the agro-industrial regions, and negative between the dynamics of the population and the dynamics of the gross regional product, as well as the number and real incomes. It is concluded that population reduction can lead to depopulation of large territories and loss of social control over them, a shortage of labor resources and limited economic growth, and a reduction in the resource base for the development of the social sphere and demographic reproduction.
Resource-based view and dynamic capabilities - Achieving competitive advantage through internal resources and competences
Authors: Enriquez de la O José Francisco
Published: December 2020

Strategy has always been important for success. Whether strategy is applied for military purposes, in large firms, or even for personal objectives, there are certain key characteristics that every successful strategy carries on: clear, objective and simple goals; deep knowledge and understanding of the competitive environment; objective understanding and exploitation of resources; and an effective plan implementation. In this paper, the author’s attention will be focused on the role of internal resources, routines and processes as the bases of sustained competitive advantage (hereafter SCA) into what is now known as the resourcebased view of the firm (RBV) and Dynamic Capabilities (DC). First, the relevance of RBV and DC approaches and the main characteristics of those are briefly mentioned. Second, RBV and DC are examined as an important piece to achieve SCA. Later on, the author deepens into some examples and the manager’s importance when using these RBV and DC approaches. Then issues related with complexity and undefined concepts in RBV and DC are briefly mentioned. Finally, conclusions and personal comments are presented.
Educação interprofissional na reorientação da formação e do modelo de atenção à saúde: desafios para a saúde coletiva
Authors: Pedrosa Claudia Mara , Furlanetto Denise de Lima Costa
Published: December 2020

A interprofissionalidade está intrínseca na proposta de criação dos curso de graduação em saúde coletiva por trazer em sua base a proposta de superação da estrutura pedagógica tradicional e disciplinar, priorizando conhecimentos e práticas que contemplem a troca de saberes e responsabilidades mútuas para formar sanitaristas comprometidos com o Sistema Único de Saúde e com as complexas necessidades de saúde. O presente trabalho tem como proposta dialogar sobre os desafios da construção curricular do curso de saúde coletiva contemplando a interprofissionalidade. Norteadas pela novas diretrizes curriculares da saúde coletiva e pela revisão do projeto político pedagógico do curso de saúde coletiva da Faculdade de Ciências da Saúde, as autoras analisaram os documentos produzidos pelos docentes nos encontros pedagógicos do Núcleo Docente Estruturante (NDE) e avaliações  dos discentes dos estágios curriculares. Foram construídas as seguintes categorias analíticas: a) identificação das necessidade da reforma do ensino em saúde coletiva na perspectiva da interprofissionalidade; b) o uso de novas metodologias pedagógicas na construção da integralização das disciplinas; c) perfil do egresso sanitarista para a atuação interprofissional. Conclui-se que apesar de os documentos analisados do NDE apresentarem objetivos e fluxos bem definidos e de complexidade crescente para construção de saberes e práticas que garantam os conhecimentos necessários para a transformação das práticas em saúde, a articulação das ações ainda não sao efetivadas no âmbito do ensino. A superação dos territórios de saberes na formação aparece como dificuldade na prática dos docentes e nos cenários de formação para a integralização da interprofissionalidade no curso. Espera-se que a enunciação das lacunas e desafios na reforma curricular da Saúde Coletiva da FS amplie os recursos pedagógicos que instrumentalizarão atores envolvidos na formação - docentes, preceptores e discentes para a construção da interprofissionalidade, considerando a equidade e a superação do modelo curricular fragmentado como elementos norteadores   do processo.
Recriar-se de subjetividades críticas na formação e no trabalho interprofissional
Authors: Pires Maria Raquel Gomes Maia , Gottems Leila Bernarda Donato
Published: December 2020

O Recriar-se (arte, lúdico e tecnologias educativas na saúde) é uma linha de produção científica do Núcleo de Pesquisa em Promoção da Saúde e Projetos Inclusivos, pertencente ao Centro de Estudos Avançados e Multidisciplinares da Universidade de Brasília (Nesprom/Ceam/UnB). Nosso compromisso é produzir conhecimentos e tecnologias lúdico- educativas para a formação e a prática de profissionais de saúde e de outras áreas, com ênfase na reinvenção de subjetividades críticas em suas dimensões éticas, estéticas, epistêmicas, política e social. O objetivo do trabalho é relatar as experiências de pesquisas do Recriar-se no fomento de subjetividades críticas de estudantes e profissionais, aplicadas aos diversos cenários do ensino e do trabalho interprofissional. Trata-se de um relato de experiência em pesquisa, produção tecnológica e narrativas lúdico-educativas de  abordagem interdisciplinar e multiprofissional oriunda da referida linha. Nos últimos sete anos, diversos projetos de pesquisas originaram três tecnologias lúdico-educativas (jogos de tabuleiro (IN)DICASUS, Banfisa e Violetas), assim como a série ‘Didáticos-para-Recriar-se’, contendo 38 produções oriundas das experiências de pesquisa, de ensino e de extensão, articuladas às manifestações da arte e do lúdico, com ricas possibilidades de reinvenção sensível, ética e política dos participantes.
Faktor yang mempengaruhi pemilihan aplikasi pembayaran seluler
Authors: Yessica Yessica , Sutanto Eddy Madiono
Published: December 2020

Of the various types of mobile payments available, DANA is one of the fast growing pay­ment applications in Indonesia. There are many pay­ment applications issued by banks and other parties. DANA is a startup that was officially introduced on March 21, 2018 as one of the digital payment services. This study aims to analyze quan­titatively what factors influence consumers in using the DANA application when conducting transactions. To mea­sure the developed model, a confir­matory factor ana­lysis model will be used. The sampling technique used in this study was to use a questionnaire. The respondents are 100 who had used the DANA payment application. The obtained data were processed using the CFA factor analysis method (con­firma­tory analysis factor). The results show that there are three main factors that in­flu­ence the choice of DANA payment applications inclu­d­ing conve­nience, compa­ti­bi­lity, and knowledge.
Pengaruh Desain Produk terhadap Keputusan Pembelian dan Dampaknya pada Kepuasan Konsumen
Authors: Handayani Jasella , Deriawan Deriawan , Hendratni Tyahya Whisnu
Published: December 2020

Penelitian ini bertujuan untuk mengetahui desain produk, keputusan pembelian, dan kepuasan konsumen Bebbi Shoes. Metode yang digunakan adalah metode kuantitatif dan analisis deskriptif dengan cara menyebarkan kuesioner kepada 100 responden yang pernah menggunakan produk Bebbi Shoes dan teknik sampling yang digunakan adalah dengan menggunakan purposive sampling . Analisis data dalam penelitian ini menggunakan analisis jalur ( path analysis ). Hasil analisis jalur dalam penelitian ini menunjukkan bahwa variabel desain produk berpengaruh signifikan terhadap variabel keputusan pembelian , variabel keputusan pembelian berpengaruh signifikan terhadap variabel kepuasan konsumen , variabel desain produk berpengaruh signifikan terhadap kepuasdan konsumen. Berdasarkan hasil penelitian ini sebaiknya pihak Bebbi Shoes meningkatkan kinerja pada desain produk dengan tujuan agar pelanggan merasa puas.
ADAPTIVE GUARANTEED ESTIMATION OF A CONSTANT SIGNAL UNDER UNCERTAINTY OF MEASUREMENT ERRORS
Authors:   South Ural State University, Khadanovich D.V. , Shiryaev V.I. ,   South Ural State University
Published: December 2020

In the guaranteed estimation problems under uncertainty relative to disturbances and meas-urement errors, the admissible sets of their possible values are determined. The solution is chosen due to conditions of guaranteed bounded estimates optimization corresponding to the worst realiza-tion of disturbances and measurement errors. The result of the guaranteed estimation is an unim-provable bounded estimate (information set), which turns to be overly pessimistic (reinsurance) if a prior admissible set of measurement errors is too large compared to their realized values. The admis-sible sets of disturbances and measurement errors can turn to be only rough upper estimates on a short observation interval. The goal of research is the accuracy enhancement problem of guaran-teed estimation when measurement errors are not realized in the worst way, i.e. the environment in which the object operates does not behave as aggressively as it is built in a priori data on the permis-sible set of error values. Research design. The problem of adaptive guaranteed estimation of a con-stant signal from noisy measurements is considered. The adaptive filtering problem is, according to the results of measurement processing, from the whole set of possible realizations of errors, to choose the one that would generate the measurement sequence. Results. An adaptive guaranteed estimation algorithm is presented. The adaptive algorithm construction is based on a multi-alternative method based on the Kalman filter bank. The method uses a set of filters, each of which is tuned to a specific hypoth-esis about the measurement error model. Filter residuals are used to compute estimates of realized measurement errors. The choice of the realization of possible errors is performed using a function that has the meaning of the residual variance over a short time interval. Conclusion. The computa-tional scheme of the adaptive algorithm, the numerical example, and comparative analysis of ob-tained estimates are presented.
DEVELOPMENT OF A MODIFIED WINNOWING METHOD FOR AGGREGATING BIBLIOGRAPHIC INFORMATION DATA FROM CITATION SYSTEMS UNDER THE CONDITIONS OF INCOMPLETE INFORMATION
Authors:   Orenburg State University, Orenburg, Russian Federation, Bolodurina I.P. , Ivanova (Lugovskova) Yu.P. ,   Orenburg State University, Orenburg, Russian Federation, Antsiferova L.M. ,   Orenburg State University, Orenburg, Russian Federation, Blinov V.D. ,   Orenburg State University, Orenburg, Russian Federation
Published: December 2020

Currently, transition to the electronic presentation of bibliographic information about scientific works has caused an increased interest in scientometric research. At the same time, the existing sci-entometric methods are criticized by scientists, since the incomplete bibliographic base and tools for its assessment do not allow the most accurate assessment of the contribution of scientific work. The problem of the quality of scientometric assessments, as a rule, is based on the study of the data of a certain citation system, which does not include complete information about all publications of the authors contained in other citation systems. Aim. This study is aimed at developing an adaptive ap-proach for the formation of aggregated data of bibliographic information of a scientific organiza-tion in conditions of incomplete information from the citation systems of the RSCI, “Google Aca-demy” and Scopus. Methods. The definition of the aggregated list of publications for the analysis of scientometric indicators was carried out by the Winnowing method, the Levenshtein algorithm, the shingle method and the Jaro–Winkler method. In the framework of the experimental study, the effectiveness of the application of the considered methods for aggregating information from cita-tion systems was assessed based on the analysis of accuracy, completeness and F-measure. Results. Expe¬riments on test data from the list of publications by authors of the Orenburg State University from the citation systems RSCI, Google Academy and Scopus showed that the Winnowing method formed the most accurate lists of publications by the F-measure criterion. To improve the perfor-mance of this algorithm, a two-stage optimization of the aggregation process was carried out, which made it possible to improve the running time of the algorithm when generating a list of bibliographic descriptions. Conclusion. The proposed approach for the formation of aggregated data of biblio-graphic information of a scientific organization in conditions of incomplete information from the ci-tation systems of the Russian Science Citation Index, Google Academy and Scopus allows increas-ing productivity in the formation of a list of authors' publications and shows good efficiency in de-termining the scientometric characteristics of authors.
ENZYME DIAGNOSTICS IN SPORTS PRACTICE (LITERATURE REVIEW AND PERSONAL EXPERIENCE)
Authors: Bakulev S , Dorofeikov V , Goldberg N , Taymazov V , Ashkinazi S , Smirnov M
Published: December 2020

Aim. The paper aims to analyze and summarize the data about enzyme diagnostics in athletes of different sports. Materials and methods. Creatine kinase (CK) activity was measured in 20 highly skilled male biathletes aged from 18 to 23 years. Fasted blood samples were taken in the morning before exercise and the next day after a 90-minute ski run by a uniform method. Biochemical analysis was performed by using the Architect c4000 and i1000SR (Abbott, USA) automated analyzers with reagents and control materials from the equipment manufacturer. Results. An increase in CK activity in biathletes is observed at the end of the preparatory period, and normalization occurs by the middle of the competitive period. When studying CK activity in 10 male handball players aged from 18 to 21 years the day after training, it was found that the increase in enzyme activity depended on the playing position. Goalkeepers exceeded the norm many times compared to field players. The highest serum CK activity after exercise was observed after prolonged exercise such as extra-long marathon and uphill running, which involved eccentric muscle contractions. In triathletes after competitions (full distance), CK activity increased to 1200 U/L, after 48 hours of recovery it dropped to 400 U/L. Conclusion. Thus, enzyme diagnostics today is a relevant and objective method for assessing the state of health and the muscular system, including organs such as the heart, liver, and brain. Therefore, control over the level of basic enzymes should be carried out regularly in the preparatory period both as part of an in-depth medical examination and if an athlete is suspected of being overtrained or injured.
RIGHT TO THE MAP? COUNTER-MAPPING PRACTICES OF SMOG ALERTS AND URBAN GREENERY MOVEMENTS IN POLAND
Authors: PUTKOWSKA-SMOTER RENATA , FRANKOWSKI JAN
Published: December 2020

Data production is becoming an emerging trend in critical urban activism. Precise and reliable public information, including spatial and environmental information, serves individual and collective ‘right to the city’ beliefs. One of the common strategies adopted by contemporary urban movements to ensure the accuracy and inclusiveness of urban data production processes are various forms of counter-mapping, which we introduce in this paper as a perspective aimed in critical evaluation of urban environmental conditions in Polish cities. By process tracing of smog alerts and urban greenery movements, we investigate the main strategies of using such tools and their effects for both particular social actors, and general urban environmental policy. We argue that the core idea of a citizen-driven collection of geographical data is strongly supported by its other features – social involvement and collective production of visualizations illustrating the scale and dynamics of particular environmental problems. In this sense, counter-mapping is aimed rather at repoliticizing urban environmental data in order to critically evaluate existing urban policy, than just to ensure greater citizen involvement in environmental decision-making.
SRPX2 boosts pancreatic cancer chemoresistance by activating PI3K/AKT axis
Authors: Gao Zhenyuan , Wu Jisong , Wu Xiao , Zheng Jialei , Ou Yimei
Published: December 2020

Background and aim

This investigation was aimed at disclosing whether SRPX2 affected pancreatic cancer (PC) chemoresistance by regulating PI3K/Akt/mTOR signaling.

Methods

Totally 243 PC patients were recruited, and they were incorporated into partial remission (PR) group, stable disease (SD) group and progressive disease (PD) group in accordance with their chemotherapeutic response. PC cell lines (i.e. AsPC1, Capan2, VFPAC-1, HPAC, PANC-1, BxPC-3 and SW1990) and human pancreatic ductal epithelial cell lines (hTERT-HPNE) were also collected.

Results

PC patients of SD + PD group were associated with higher post-chemotherapeutic SRPX2 level than PR group, and their post-chemotherapeutic SRPX2 level was above the pretherapeutic SRPX2 level (P < 0.05). PR population showed lower SRPX2 level after chemotherapy than before chemotherapy (P < 0.05). Besides high serum SRPX2 level and SRPX2 level change before and after chemotherapy were independent predictors of poor PC prognosis. Additionally, si-SRPX2 enhanced chemosensitivity of PC cell lines, and expressions of p-PI3K, p-AKT and p-mTOR were suppressed by si-SRPX2 (P < 0.05). IGF-1 treatment could changeover the impact of si-SRPX2 on proliferation, migration, invasion and chemoresistance of PC cells (P < 0.05).

Conclusion

The SRPX2-PI3K/AKT/mTOR axis could play a role in modifying progression and chemoresistance of PC cells, which might help to improve PC prognosis.
Hallazgos neuro-estrabismológicos en una paciente con Síndrome de Kabuki
Authors: Gallegos-Duarte Martín , Gutiérrez-Álvarez Isidro , Ibrahimi Danjela , Gutiérrez-Villaseñor Isidro
Published: December 2020

El síndrome de Kabuki es un trastorno congénito, evolutivo y permanente que posee manifestaciones clínicas características. Se presenta el caso de una niña con diagnóstico de síndrome de Kabuki MLL2 positivo a quien se le realizó tipificación, caracterización clínica, estudio oftalmológico, estrabismoglógico, análisis perceptual visual, optométrico y estudios de neuroimagen. Se identificó facies característica, estrabismo disociado, anisocoria, disminución de habilidades perceptuales, hipocoherencia y asimetría interhemisférica importante para Delta y Theta, disminución del volumen del hipocampo izquierdo y de la arborización de la vía visual en su porción posterior izquierda, disminución de la colina y un incremento del lactato cortical. El estudio reveló alteraciones corticales y de la vía visual.
Conservación y destrucción de las esculturas de verracos. Su reaprovechamiento como modo de preservación
Authors: Manglano Valcárcel Gregorio Ramón , González-Ruiz Ana
Published: December 2020

Las esculturas zoomorfas labradas en granito por uno de los pueblos prerromanos célticos que habitaban la Península Ibérica, llegaron a constituir el más significativo símbolo de su identidad territorial y cultural. Los vettones entendieron estas piezas como elementos delimitadores del paisaje y de los recursos. Más adelante, con la llegada a sus tierras de Roma, estas esculturas se seguirían produciendo, pero su sentido y finalidad cambiarían para incorporarse al mundo funerario e irían, paulatinamente, dejando de realizarse. En el trabajo se abordan los avatares y vicisitudes padecidas por estas singulares representaciones tras la desaparición de la cultura que las creó, poniendo especial atención en aquellas piezas que, de una u otra forma, fueron reutilizadas.
What is the Meaning of Immanuel Kant’s Notion of the Human Being as the Ultimate End of Nature?
Authors: Bacevičiūtė Danutė
Published: December 2020

The article explores Kant’s notion of the human being as the ultimate end of nature, presenting an ethical interpretation of this notion. The author of this article believes that the analysis of Kant’s assumptions will allow a deeper understanding of our own hermeneutical situation, in which ecological problems force us to rethink our relationship with nature and the meaning of human existence. Analyzing Kant’s early texts on Lisbon earthquake and his reflection on the sublime in the Critique of Judgement, the author asks how the experience of an uncontrolled natural element complements Kant’s ethical vision of nature’s teleology. Emphasizing the importance of insight into human vulnerability for the implementation of moral purpose in nature, the article outlines guidelines for interpretation that allow the relevance of Kant’s position in the context of contemporary environmental ethics.