bluuebunny/crossref_metadata_2025 huggingface dataset:
Modeling and Experimental Verification of Material Welding Characteristics for Low Current Switching Devices
Authors: Zhang Xu , Ren Wanbin
Published: August 2020

Material welding failure considerably influences the electrical lifetime and reliability of low current switching devices. However, relevant studies on methods for calculating the threshold welding current and welding area under milli-Newton scale load forces are very limited. In this paper, the welding characteristics of metal material, including the threshold welding current, welding area and welding force are studied by using theoretical calculations and experiments. The comparison between the theoretical calculation and experimental results shows the accuracy of the built model. Further, the effects of mechanical load force and load current on welding force and welding area of representative metal materials are investigated. It is found that the anti-welding ability of metal materials depends not only on the exerted load force and current, but also the electrical resistivity, the thermal conductivity, the tensile strength, and the melting temperature of the materials.
Improving the Forming Quality of Laser Dynamic Flexible Micropunching by Laser Pre-Shocking
Authors: Zhang Jindian , Shen Zongbao , Lin Youyu , Liu Kai , Zhou Guoyang , Wang Yang , Zhang Lei , Li Pin , Liu Huixia , Wang Xiao
Published: August 2020

Laser pre-shocking (LPS) was introduced into the laser dynamic flexible micropunching process to refine the grain size of a workpiece to improve the forming quality of punched parts. T2 copper foils with five different grain sizes and seven different laser power densities with and without LPS were used for the experiment. The results showed that the grains are refined and the average surface roughness Ra decreases after LPS. For copper foils annealed at 650 °C, the value of Ra decreases from 0.430 to 0.363 µm. The increase in laser energy density and grain size leads to the deterioration of the fracture surface. LPS can improve the quality of the fracture surface. Compared with punched holes without LPS, the dimensional accuracy and shape accuracy of punched holes can be improved by LPS. When grain size is close to the thickness of the copper foil, the forming quality of the punched parts becomes uncertain, owing to the difference in the orientation of the initial grains. The instability of laser dynamic flexible micropunching can be reduced by LPS. Especially, the improvement of forming quality of the punched part brought by LPS is significant for the copper foils with coarse grains.
A Perspective on Enzyme Inhibitors from Marine Organisms
Authors: Tischler Dirk
Published: August 2020

Marine habitats are promising sources for the identification of novel organisms as well as natural products. Still, we lack detailed knowledge on most of the marine biosphere. In the last decade, a number of reports described the potential of identifying novel bioactive compounds or secondary metabolites from marine environments. This is, and will be, a promising source for candidate compounds in pharma research and chemical biology. In recent years, a number of novel techniques were introduced into the field, and it has become easier to actually prospect for natural products, such as enzyme inhibitors. These novel compounds then need to be characterized and evaluated in comparison to well-known representatives. A number of current research projects target the exploitation of marine organisms and thus the corresponding diversity of metabolites. These are often encountered as potential drugs or biological active compounds. Among these, the class of enzyme inhibitors is an important group of compounds. There is room for new discoveries, and some more recent discoveries are highlighted herein.
Expression of Genes Related to Carrageenan Synthesis during Carposporogenesis of the Red Seaweed Grateloupia imbricata
Authors: Garcia-Jimenez Pilar , Mantesa Sara R. , Robaina Rafael R.
Published: August 2020

Carrageenan, the foremost constituent of extracellular matrix of some rhodophyta, is a galactan backbone with a different number of sulphate groups attached. Variations of degree of sulphation are associated with different types of carrageenans, which vary according to seaweed life cycles, and have consequences for the exploitation of this raw material. In this work, we used three well-recognised stages of development thalli and two stages of cystocarp maturation to analyse genes that encode addition and elimination of sulphate groups to cell-wall galactan of the red seaweed Grateloupia imbricata. Expressions of carbohydrate sulfotransferase and galactose-6 sulfurylase and genes encoding stress proteins such as cytochrome P450 and WD40, were examined. Results showed that transcript expression of carbohydrate sulfotransferase occurs at all stage of thalli development. Meanwhile galactose-6 sulfurylase expressions displayed different roles, which could be related to a temporal regulation of cystocarp maturation. Cytochrome P450 and WD40 are related to the disclosure and maturation of cystocarps of G. imbricata. Our conclusion is that differential expression of genes encoding proteins involved in the sulphation and desulphation of galactan backbone is associated with alterations in thalli development and cystocarp maturation in the red seaweed Grateloupia imbricata. Exploitation of industry-valued carrageenan will depend on insight into gene mechanisms of red seaweeds.
A Study on the Improvement of the Durability of an Energy Harvesting Device with a Mechanical Stopper and a Performance Evaluation for Its Application in Trains
Authors: Kim Jaehoon
Published: August 2020

Durability is one of the critical issues concerning energy harvesting devices. Even with the energy harvesting device’s excellent performance design, the moving components, such as the spring, get damaged during operation. In this study, an energy harvesting device was designed for durability improvement. The mechanical stopper of the energy harvesting device was selected as a new design component to prevent spring damage. An experimental and finite element analysis (FEA) was carried out on the amount of energy harvesting power possible using a mechanical stopper to improve the durability of the energy harvesting device. A performance evaluation of the energy harvesting device using the mechanical stopper was conducted under laboratory and driving conditions of a high-speed train traveling at 300 km/h. The measurement of the generated power gives the target value for the minimum performance of the newly designed energy harvesting device used as the power source of the wireless sensor node for high-speed trains.
Improved High-Yield PMMA/Graphene Pressure Sensor and Sealed Gas Effect Analysis
Authors: Liu Ying , Zhang Yong , Lin Xin , Lv Ke-hong , Yang Peng , Qiu Jing , Liu Guan-jun
Published: August 2020

Graphene with atomic thickness possesses excellent mechanical and electrical properties, which hold great potential for high performance pressure sensing. The exposed electron of graphene is always cross-sensitive to any pollution absorbed or desorbed on the surface, from which the long-term stability of the graphene pressure sensor suffers a lot. This is one of the main obstacles towards graphene commercial applications. In this paper, we utilized polymethylmethacrylate (PMMA)/graphene heterostructure to isolate graphene from the ambient environment and enhance its strength simultaneously. PMMA/graphene pressure sensors, with the finite-depth cavities and the through-hole cavities separately, were made for comparative study. The through-hole device obtained a comparable sensitivity per unit area to the state of the art of the bare graphene pressure sensor, since there were no leaking cracks or defects. Both the sensitivity and stability of the through-hole sensor are better than those of the sensor with 285-nm-deep cavities, which is due to the sealed gas effect in the pressure cavity. A modified piezoresistive model was derived by considering the pressure change of the sealed gas in the pressure cavity. The calculated result of the new model is consistent with the experimental results. Our findings point out a promising route for performance optimization of graphene pressure sensors.
Microfluidics-Based Systems in Diagnosis of Alzheimer’s Disease and Biomimetic Modeling
Authors: Li Yan , Li Danni , Zhao Pei , Nandakumar Krishnaswamy , Wang Liqiu , Song Youqiang
Published: August 2020

Early detection and accurate diagnosis of Alzheimer’s disease (AD) is essential for patient care and disease treatment. Microfluidic technology is emerging as an economical and versatile platform in disease detection and diagnosis. It can be conveniently integrated with nanotechnology and/or biological models for biomedical functional and pre-clinical treatment study. These strengths make it advantageous in disease biomarker detection and functional analysis against a wide range of biological backgrounds. This review highlights the recent developments and trends of microfluidic applications in AD research. The first part looks at the principles and methods for AD diagnostic biomarker detection and profiling. The second part discusses how microfluidic chips, especially organ-on-a-chip platforms, could be used as an independent approach and/or integrated with other technologies in AD biomimetic functional analysis.
Disposable and Low-Cost Electrode Based on Graphene Paper-Nafion-Bi Nanostructures for Ultra-Trace Determination of Pb(II) and Cd(II)
Authors: Scandurra Antonino , Ruffino Francesco , Urso Mario , Grimaldi Maria Grazia , Mirabella Salvo
Published: August 2020

There is a huge demand for rapid, reliable and low-cost methods for the analysis of heavy metals in drinking water, particularly in the range of sub-part per billion (ppb). In the present work, we describe the preparation, characterization and analytical performance of the disposable sensor to be employed in Square Wave Anodic Stripping Voltammetry (SWASV) for ultra-trace simultaneous determination of cadmium and lead. The electrode consists of graphene paper-perfluorosulfonic ionomer-bismuth nano-composite material. The electrode preparation implies a key step aimed to enhance the Bi3+ adsorption into nafion film, prior to the bismuth electro-deposition. Finely dispersed bismuth nanoparticles embedded in the ionomer film are obtained. The electrode was characterized by Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDX), Atomic Force Microscopy (AFM), X-ray Photoelectron Spectroscopy (XPS) and Electrochemical Impedance Spectroscopy (EIS). The electrode shows a linear response in the 5–100 ppb range, a time-stability tested up to almost three months, and detection limits up to 0.1 ppb for both Pb2+ and Cd2+. The electrode preparation method is simple and low in cost and the obtained analytical performance is very competitive with the state of art for the SWASV determination of Pb2+ and Cd2+ in solution.
An Improved Method for Estimating Core Size Distributions of Magnetic Nanoparticles via Magnetization Harmonics
Authors: Sun Yi , Ye Na , Wang Dandan , Du Zhongzhou , Bai Shi , Yoshida Takashi
Published: August 2020

The core size distribution is an important physical characteristic of magnetic nanoparticles (MNPs) because it seriously affects biomedical and biological applications. In this study, we proposed an improved method for estimating the distributions, which optimizes the excitation frequency based on AC susceptibility to avoid the effects of Brownian relaxation. Moreover, the first, third, and fifth magnetization harmonics under different excitation field strengths are used for estimating core size distributions to avoid measuring higher harmonics. The experiment results show that the improved AC harmonic method can accurately and quickly estimate the distribution of large core sizes compared with the method of static magnetization (M–H) curves, which is a competitive advantage in MNP immunoassays.
A Paradoxical Vasodilatory Nutraceutical Intervention for Prevention and Attenuation of Migraine—A Hypothetical Review
Authors: Chaliha Devahuti Rai , Vaccarezza Mauro , Takechi Ryu , Lam Virginie , Visser Eric , Drummond Peter , Mamo John Charles Louis
Published: August 2020

Studies suggest that migraine pain has a vascular component. The prevailing dogma is that peripheral vasoconstriction activates baroreceptors in central, large arteries. Dilatation of central vessels stimulates nociceptors and induces cortical spreading depression. Studies investigating nitric oxide (NO) donors support the indicated hypothesis that pain is amplified when acutely administered. In this review, we provide an alternate hypothesis which, if substantiated, may provide therapeutic opportunities for attenuating migraine frequency and severity. We suggest that in migraines, heightened sympathetic tone results in progressive central microvascular constriction. Suboptimal parenchymal blood flow, we suggest, activates nociceptors and triggers headache pain onset. Administration of NO donors could paradoxically promote constriction of the microvasculature as a consequence of larger upstream central artery vasodilatation. Inhibitors of NO production are reported to alleviate migraine pain. We describe how constriction of larger upstream arteries, induced by NO synthesis inhibitors, may result in a compensatory dilatory response of the microvasculature. The restoration of central capillary blood flow may be the primary mechanism for pain relief. Attenuating the propensity for central capillary constriction and promoting a more dilatory phenotype may reduce frequency and severity of migraines. Here, we propose consideration of two dietary nutraceuticals for reducing migraine risk: L-arginine and aged garlic extracts.
Vitamin D Insufficiency and Deficiency and Mortality from Respiratory Diseases in a Cohort of Older Adults: Potential for Limiting the Death Toll during and beyond the COVID-19 Pandemic?
Authors: Brenner Hermann , Holleczek Bernd , Schöttker Ben
Published: August 2020

The COVID-19 pandemic goes along with increased mortality from acute respiratory disease. It has been suggested that vitamin D3 supplementation might help to reduce respiratory disease mortality. We assessed the prevalence of vitamin D insufficiency and deficiency, defined by 25-hydroxyvitamin D (25(OH)D) blood levels of 30–50 and <30 nmol/L, respectively, and their association with mortality from respiratory diseases during 15 years of follow-up in a cohort of 9548 adults aged 50–75 years from Saarland, Germany. Vitamin D insufficiency and deficiency were common (44% and 15%, respectively). Compared to those with sufficient vitamin D status, participants with vitamin D insufficiency and deficiency had strongly increased respiratory mortality, with adjusted hazard ratios (95% confidence intervals) of 2.1 (1.3–3.2) and 3.0 (1.8–5.2) overall, 4.3 (1.3–14.4) and 8.5 (2.4–30.1) among women, and 1.9 (1.1–3.2) and 2.3 (1.1–4.4) among men. Overall, 41% (95% confidence interval: 20–58%) of respiratory disease mortality was statistically attributable to vitamin D insufficiency or deficiency. Vitamin D insufficiency and deficiency are common and account for a large proportion of respiratory disease mortality in older adults, supporting the hypothesis that vitamin D3 supplementation could be helpful to limit the burden of the COVID-19 pandemic, particularly among women.
Plasma Lithium Levels in the General Population: A Cross-Sectional Analysis of Metabolic and Dietary Correlates
Authors: Enderle Janna , Klink Urte , di Giuseppe Romina , Koch Manja , Seidel Ulrike , Weber Katharina , Birringer Marc , Ratjen Ilka , Rimbach Gerald , Lieb Wolfgang
Published: August 2020

Initial evidence suggests that lithium might affect life expectancy and the risk for different disease conditions, but most studies were conducted in patients on lithium medication. Little is known about the association of blood lithium levels within the physiological range with cardiometabolic risk factors and diet. We measured plasma lithium in a community-based sample from Northern Germany (samples taken between 2010 and 2012). All participants (aged 25–82 years) underwent standardized examinations and completed a semi-quantitative food frequency questionnaire. Of several variables tested, the estimated glomerular filtration rate (eGFR) was statistically significantly (inversely) associated with lithium levels, mainly in individuals with slightly impaired renal function (eGFR < 75 mL/min/1.73 m2). Besides, lithium levels were positively associated with age and alcohol intake. Using reduced rank regression, we identified a dietary pattern explaining 8.63% variation in plasma lithium levels. Higher lithium levels were associated with higher intakes of potatoes, leafy vegetables, root vegetables, fruits, tea, beer, wine and dietetic products and lower intakes of pasta, rice, pork, chocolate, sweets, soft drinks, other alcoholic beverages, sauces and snacks. Our observations suggest that plasma lithium levels are associated inversely with kidney function, particularly in individuals with slightly impaired renal function, and positively with age and alcohol intake. Lithium at physiological levels was moderately related to an exploratory dietary pattern.
Association of Dietary Micronutrient Intake with Pulmonary Tuberculosis Treatment Failure Rate: ACohort Study
Authors: Xiong Ke , Wang Jinyu , Zhang Jianwen , Hao Haibo , Wang Qiuzhen , Cai Jing , Ma Aiguo
Published: August 2020

Malnutrition is associated with an increased risk of pulmonary tuberculosis (PTB) treatment failure. Currently, there is no effective adjunctive nutritional therapy. The current objective is to investigate the association of dietary micronutrient intake with PTB treatment outcome.A cohort study including 1834 PTB patients was conducted in Linyi, China. The dietary micronutrient intake was assessed through a three-day 24 h dietary recall questionnaire. The treatment outcome was assessed by combinations of sputum smear and computerized tomography results. A multivariate binary regression model was used to assess the associations. The final model was adjusted for potential confounding factors. A low intake of vitamin C (adjusted OR (95% CI): 1.80 (1.07, 3.04), Ptrend = 0.02) and Zn (adjusted OR (95% CI): 2.52 (1.25, 5.08), Ptrend = 0.02) was associated with a high treatment failure rate. In addition, a low intake of vitamin C and Mn was associated with a severe tuberculosis symptom, as indicated by a high TB score. A supplementation of vitamin C and Zn may be beneficial in PTB treatment. Previous meta-analysis of randomized controlled trials (RCTs) reported a null effect of Zn supplementation on PTB treatment. The effect of vitamin C supplementation should be investigated by RCTs.
Can Creatine Supplementation Interfere with Muscle Strength and Fatigue in Brazilian National Level Paralympic Powerlifting?
Authors: Soares Freitas Sampaio Carlos Rodrigo , Aidar Felipe J. , Ferreira Alexandre R. P. , Santos Jymmys Lopes dos , Marçal Anderson Carlos , Matos Dihogo Gama de , Souza Raphael Fabrício de , Moreira Osvaldo Costa , Guerra Ialuska , Fernandes Filho José , Marcucci-Barbosa Lucas Soares , Nunes-Silva Albená , Almeida-Neto Paulo Francisco de , Cabral Breno Guilherme Araújo Tinoco , Reis Victor Machado
Published: August 2020

The aim of the present study was to analyze the effect of creatine (Cr) supplementation on peak torque (PT) and fatigue rate in Paralympic weightlifting athletes. Eight Paralympic powerlifting athletes participated in the study, with 25.40 ± 3.30 years and 70.30 ± 12.15 kg. The measurements of muscle strength, fatigue index (FI), peak torque (PT), force (kgf), force (N), rate of force development (RFD), and time to maximum isometric force (time) were determined by a Musclelab load cell. The study was performed in a single-blind manner, with subjects conducting the experiments first with placebo supplementation and then, following a 7-day washout period, beginning the same protocol with creatine supplementation for 7 days. This sequence was chosen because of the lengthy washout of creatine. Regarding the comparison between conditions, Cr supplementation did not show effects on the variables of muscle force, peak torque, RFD, and time to maximum isometric force (p > 0.05). However, when comparing the results of the moments with the use of Cr and placebo, a difference was observed for the FI after seven days (U3: 1.12; 95% CI: (0.03, 2.27); p = 0.02); therefore, the FI was higher for placebo. Creatine supplementation has a positive effect on the performance of Paralympic powerlifting athletes, reducing fatigue index, and keeping the force levels as well as PT.
Effects of Exogenous Dietary Advanced Glycation End Products on the Cross-Talk Mechanisms Linking Microbiota to Metabolic Inflammation
Authors: Mastrocola Raffaella , Collotta Debora , Gaudioso Giulia , Le Berre Marie , Cento Alessia Sofia , Ferreira Alves Gustavo , Chiazza Fausto , Verta Roberta , Bertocchi Ilaria , Manig Friederike , Hellwig Michael , Fava Francesca , Cifani Carlo , Aragno Manuela , Henle Thomas , Joshi Lokesh , Tuohy Kieran , Collino Massimo
Published: August 2020

Heat-processed diets contain high amounts of advanced glycation end products (AGEs). Here we explore the impact of an AGE-enriched diet on markers of metabolic and inflammatory disorders as well as on gut microbiota composition and plasma proteins glycosylation pattern. C57BL/6 mice were allocated into control diet (CD, n = 15) and AGE-enriched diet (AGE-D, n = 15) for 22 weeks. AGE-D was prepared replacing casein by methylglyoxal hydroimidazolone-modified casein. AGE-D evoked increased insulin and a significant reduction of GIP/GLP-1 incretins and ghrelin plasma levels, altered glucose tolerance, and impaired insulin signaling transduction in the skeletal muscle. Moreover, AGE-D modified the systemic glycosylation profile, as analyzed by lectin microarray, and increased Nε-carboxymethyllysine immunoreactivity and AGEs receptor levels in ileum and submandibular glands. These effects were associated to increased systemic levels of cytokines and impaired gut microbial composition and homeostasis. Significant correlations were recorded between changes in bacterial population and in incretins and inflammatory markers levels. Overall, our data indicates that chronic exposure to dietary AGEs lead to a significant unbalance in incretins axis, markers of metabolic inflammation, and a reshape of both the intestinal microbiota and plasma protein glycosylation profile, suggesting intriguing pathological mechanisms underlying AGEs-induced metabolic derangements.
The Effect of Labelling and Visual Properties on the Acceptance of Foods Containing Insects
Authors: Modlinska Klaudia , Adamczyk Dominika , Goncikowska Katarzyna , Maison Dominika , Pisula Wojciech
Published: August 2020

Introducing insects as a source of nutrients (e.g., protein) plays a key role in many countries’ environmental policies. However, westerners generally reject insects as an ingredient of food products and meals. The aim of our study was to assess if explicitly labelling food as containing insects and/or implying it by manipulating the appearance of food influences the participants’ perception of food products or their behavioral reaction to such products. Participants were asked to try a range of foods, none of which contained ingredients derived from insects. However, the experimental conditions varied with regard to food labelling (insect content) and appearance (traces of insect-like ingredients). We observed the participants’ non-verbal behavioral reactions to the foods. Next, the respondents filled in a questionnaire evaluating the food’s properties. Additionally, we asked the participants to fill in a set of questionnaires measuring other variables (food neophobia, disgust, variety seeking, etc.) The results showed that products labelled as containing insects are consumed with reluctance and in lower quantities despite their appearance. In addition, people with lower general neophobia and a higher tendency to seek variety tried the insect-labelled samples sooner than people from the other groups. Recommendations for marketing strategies are provided.
Interaction between Gut Microbiota and Curcumin: A New Key of Understanding for the Health Effects of Curcumin
Authors: Scazzocchio Beatrice , Minghetti Luisa , D’Archivio Massimo
Published: August 2020

Curcumin, a lipophilic polyphenol contained in the rhizome of Curcuma longa (turmeric), has been used for centuries in traditional Asian medicine, and nowadays it is widely used in food as dietary spice worldwide. It has received considerable attention for its pharmacological activities, which appear to act primarily through anti-inflammatory and antioxidant mechanisms. For this reason, it has been proposed as a tool for the management of many diseases, among which are gastrointestinal and neurological diseases, diabetes, and several types of cancer. However, the pharmacology of curcumin remains to be elucidated; indeed, a discrepancy exists between the well-documented in vitro and in vivo activities of curcumin and its poor bioavailability and chemical instability that should limit any therapeutic effect. Recently, it has been hypothesized that curcumin could exert direct regulative effects primarily in the gastrointestinal tract, where high concentrations of this polyphenol have been detected after oral administration. Consequently, it might be hypothesized that curcumin directly exerts its regulatory effects on the gut microbiota, thus explaining the paradox between its low systemic bioavailability and its wide pharmacological activities. It is well known that the microbiota has several important roles in human physiology, and its composition can be influenced by a multitude of environmental and lifestyle factors. Accordingly, any perturbations in gut microbiome profile or dysbiosis can have a key role in human disease progression. Interestingly, curcumin and its metabolites have been shown to influence the microbiota. It is worth noting that from the interaction between curcumin and microbiota two different phenomena arise: the regulation of intestinal microflora by curcumin and the biotransformation of curcumin by gut microbiota, both of them potentially crucial for curcumin activity. This review summarizes the most recent studies on this topic, highlighting the strong connection between curcumin and gut microbiota, with the final aim of adding new insight into the potential mechanisms by which curcumin exerts its effects.
Frequency of Restaurant, Delivery and Takeaway Usage Is Not Related to BMI among Adults in Scotland
Authors: Albalawi Ahmad , Hambly Catherine , Speakman John R.
Published: August 2020

Background: The frequency of visits to restaurants has been suggested to contribute to the pandemic of obesity. However, few studies have examined how individual use of these restaurants is related to Body Mass Index (BMI). Aim: To investigate the association between the usage of different types of food outlets and BMI among adults in Scotland. Method: The study was cross-sectional. Participants completed an online survey for seven consecutive days where all food purchased at food outlets was reported each day. We explored the relationship between BMI and usage of these food outlets. Results: The total number of participants that completed the survey was 681. The BMI of both males and females was not related to frequency of use of Full-Service Restaurants (FSRs), Fast-Food Restaurants (FFRs), delivery or takeaways, when assessed individually or combined (TFOs = total food outlets). Conclusion: These cross-sectional data do not support the widespread belief that consumption of food out of the home at fast-food and full-service restaurants, combined with that derived from deliveries and takeaways, is a major driver of obesity in Scotland.
Dietary Acrylamide Intake and the Risk of Liver Cancer: The Japan Public Health Center-Based Prospective Study
Authors: Zha Ling , Sobue Tomotaka , Kitamura Tetsuhisa , Kitamura Yuri , Ishihara Junko , Kotemori Ayaka , Liu Rong , Ikeda Sayaka , Sawada Norie , Iwasaki Motoki , Tsugane Shoichiro ,   for the JPHC Study Group
Published: August 2020

Acrylamide has been studied for its carcinogenicity in experimental animals, causing tumors at several organ sites, and has been considered probably carcinogenic to humans as well. Given the small number of epidemiological studies that have been conducted, it is still uncertain whether the consumption of acrylamide is associated with liver cancer. Therefore, we investigated a study to determine the possible relationship between acrylamide intake and the risk of developing liver cancer in the Japanese population. A total of 85,305 participants, from the Japan Public Health Center-based Prospective Study, who provided a validated food-frequency questionnaire were enrolled between 1995 and 1998. During a median of 16.0 years follow-up, 744 new liver cancer cases were identified. Compared to the lowest tertile of acrylamide consumption (<4.8 µg/day), the multivariate hazard ratio (HR) for the highest tertile (≥7.6 µg/day) was 0.79 (95% confidence interval [CI] = 0.65–0.95) for liver cancer using multivariable model 1, adjusted for smoking status, body mass index (BMI), physical activity, medical history, and alcohol consumption; whereas the inverse relationship disappeared after additionally adjusting for coffee consumption in multivariable model 2 with HR of 1.08 (95% CI = 0.87–1.34) for the highest tertile. The effect of dietary acrylamide intake on the risk of liver cancer was not observed in the Japanese population.
A Combination of Apple Vinegar Drink with Bacillus coagulans Ameliorates High Fat Diet-Induced Body Weight Gain, Insulin Resistance and Hepatic Steatosis
Authors: Urtasun Raquel , Díaz-Gómez Joana , Araña Miriam , Pajares María José , Oneca María , Torre Paloma , Jiménez Maddalen , Munilla Germán , Barajas Miguel , Encío Ignacio
Published: August 2020

Obesity is a worldwide epidemic characterized by excessive fat accumulation, associated with multiple comorbidities and complications. Emerging evidence points to gut microbiome as a driving force in the pathogenesis of obesity. Vinegar intake, a traditional remedy source of exogenous acetate, has been shown to improve glycemic control and to have anti-obesity effects. New functional foods may be developed by supplementing traditional food with probiotics. B. coagulans is a suitable choice because of its resistance to high temperatures. To analyze the possible synergic effect of Vinegar and B. coagulans against the metabolic alterations induced by a high fat diet (HFD), we fed twelve-week-old C57BL/6 mice with HFD for 5 weeks after 2 weeks of acclimation on a normal diet. Then, food intake, body weight, blood biochemical parameters, histology and liver inflammatory markers were analyzed. Although vinegar drink, either alone or supplemented with B. coagulans, reduced food intake, attenuated body weight gain and enhanced glucose tolerance, only the supplemented drink improved the lipid serum profile and prevented hepatic HFD-induced overexpression of CD36, IL-1β, IL-6, LXR and SREBP, thus reducing lipid deposition in the liver. The beneficial properties of the B. coagulans-supplemented vinegar appear to be mediated by a reduction in insulin and leptin circulating levels.
An Investigation of the Influence of Age and Saliva Flow on the Oral Retention of Whey Protein and Its Potential Effect on the Perception and Acceptance of Whey Protein Beverages
Authors: Norton Victoria , Lignou Stella , Bull Stephanie , Gosney Margot , Methven Lisa
Published: August 2020

Protein fortified products are regularly recommended to older adults to improve nutritional status and limit sarcopenia. However protein fortification can elicit negative sensory attributes such as mouthdrying. Sensitivity to mouthdrying can increase with age, yet the influence of saliva flow and mucoadhesion remain uncertain. Here, two studies tested different whey protein beverages (WPB); 22 healthy younger volunteers completed a pilot and 84 healthy volunteers from two age groups (18–30; 65+) completed the main study. In both studies salivary flow rates (mL/min) were measured and saliva samples were collected at time intervals post beverage consumption to measure mucoadhesion to the oral cavity, where protein concentration was analysed by Bradford Assay. Volunteers rated perception and acceptability of WPBs in the main study. WPB consumption resulted in significantly increased protein concentration (p < 0.0001) in saliva samples compared with a control whey permeate beverage. Older adults had significantly lower unstimulated saliva flow (p = 0.003) and significantly increased protein concentration (p = 0.02) in saliva samples, compared with younger adults. Heating of WPB significantly (p < 0.05) increased mouthdrying and thickness perception and reduced sweetness compared with unheated WPB. Mucoadhesion is concluded to be a true phenomenon in WPBs and increases with age.
The Effect of Voluntary Exercise on Gut Microbiota in Partially Hydrolyzed Guar Gum Intake Mice under High-Fat Diet Feeding
Authors: Aoki Takafumi , Oyanagi Eri , Watanabe Chihiro , Kobiki Nanako , Miura Suzuka , Yokogawa Yuka , Kitamura Hiromi , Teramoto Fusako , Kremenik Michael J. , Yano Hiromi
Published: August 2020

Although dietary fiber treatment alters the gut microbiota and its metabolite production, it is unclear whether or not exercise habits can have a supplemental effect on changes in gut microbiota in dietary fiber-treated mice. To clarify the supplemental effect of voluntary exercise on gut microbiota in partially hydrolyzed guar gum (PHGG), which is a soluble dietary fiber, treated mice under high-fat diet (HFD) feeding, 4-week-old male C57BL/6J mice (n = 80) were randomly divided into two dietary groups: the control-diet (CD) and HFD. Then, each dietary group was treated with or without PHGG, and with or without wheel running. After the experimental period, measurement of maximal oxygen consumption, a glucose tolerance test and fecal materials collection for analysis of gut microbiota were carried out. Voluntary exercise load in PHGG treatment under HFD feeding showed the supplemental effect of exercise on obesity (p < 0.01) and glucose tolerance (p < 0.01). Additionally, in both CD and HFD groups, voluntary exercise accelerated the decrease in the Firmicutes/Bacteroidetes ratio in mice fed with PHGG (p < 0.01). These findings suggest that voluntary exercise might activate the prevention of obesity and insulin resistance more via change in gut microbiota in mice administrated with PHGG.
Religions as Innovative Traditions: The Case of the Juhuro of Moscow
Authors: Anello Giancarlo , Carluccio Antonio
Published: August 2020

This paper examines some historical, cultural, and institutional processes involving a Jewish minority from the Russian and Azerbaijani Caucasus, now mostly displaced in the huge and multiethnic Moscow: the Mountain Jews, or Juhuro. These Jews were subjected to a historically multifaceted and endangering diaspora, but they have been making big efforts to preserve their identity and survival by means of accommodating, mimetic, and cultural strategies. In the present day, despite the few representatives living in the Russian capital, the community is striving to find its own niche to transmit its history, language, and tradition within the multicultural “salad bowl” city of Moscow. More changes and transformations are at stake to preserve their long-lasting ethnic, religious, and linguistic characteristics. This paper is devoted to analyzing such elements, in an attempt to explain why and how Juhuro seem likely to succeed in preserving their religious community by innovating it in spite of their minority position within a globalized society.
Benefits and Lessons Learned from the Sentinel-3 Tandem Phase
Authors: Clerc Sébastien , Donlon Craig , Borde Franck , Lamquin Nicolas , Hunt Samuel E. , Smith Dave , McMillan Malcolm , Mittaz Jonathan , Woolliams Emma , Hammond Matthew , Banks Christopher , Moreau Thomas , Picard Bruno , Raynal Matthias , Rieu Pierre , Guérou Adrien
Published: August 2020

During its commissioning phase, the Copernicus Sentinel-3B satellite has been placed in a tandem formation with Sentinel-3A for a period of 6 months. This configuration allowed a direct comparison of measurements obtained by the two satellites. The purpose of this paper was to present the range of analyses that can be performed from this dataset, highlighting methodology aspects and the main outcomes for each instrument. We examined, in turn, the benefit of the tandem in understanding instrument operational modes differences, in assessing inter-satellite differences, and in validating measurement uncertainties. The results highlighted the very good consistency of the Sentinel-3A and B instruments, ensuring the complete inter-operability of the constellation. Tandem comparisons also pave the way for further improvements through harmonization of the sensors (OLCI), correction of internal stray-light sources (SLSTR), or high-frequency processing of SRAL SARM data. This paper provided a comprehensive overview of the main results obtained, as well as insights into some of the results. Finally, we drew the main lessons learned from the Sentinel-3 tandem phase and provided recommendations for future missions.
Distributed Training and Inference of Deep Learning Models for Multi-Modal Land Cover Classification
Authors: Aspri Maria , Tsagkatakis Grigorios , Tsakalides Panagiotis
Published: August 2020

Deep Neural Networks (DNNs) have established themselves as a fundamental tool in numerous computational modeling applications, overcoming the challenge of defining use-case-specific feature extraction processing by incorporating this stage into unified end-to-end trainable models. Despite their capabilities in modeling, training large-scale DNN models is a very computation-intensive task that most single machines are often incapable of accomplishing. To address this issue, different parallelization schemes were proposed. Nevertheless, network overheads as well as optimal resource allocation pose as major challenges, since network communication is generally slower than intra-machine communication while some layers are more computationally expensive than others. In this work, we consider a novel multimodal DNN based on the Convolutional Neural Network architecture and explore several different ways to optimize its performance when training is executed on an Apache Spark Cluster. We evaluate the performance of different architectures via the metrics of network traffic and processing power, considering the case of land cover classification from remote sensing observations. Furthermore, we compare our architectures with an identical DNN architecture modeled after a data parallelization approach by using the metrics of classification accuracy and inference execution time. The experiments show that the way a model is parallelized has tremendous effect on resource allocation and hyperparameter tuning can reduce network overheads. Experimental results also demonstrate that proposed model parallelization schemes achieve more efficient resource use and more accurate predictions compared to data parallelization approaches.
The Accuracy of Real-Time hmF2 Estimation from Ionosondes
Authors: Scotto Carlo , Sabbagh Dario
Published: August 2020

A total of 4991 ionograms recorded from April 1997 to December 2017 by the Millstone Hill Digisonde (42.6°N, 288.5°E) were considered, with simultaneous Ne(h)[ISR] profiles recorded by the co-located Incoherent Scatter Radar (ISR). The entire ionogram dataset was scaled with both the Autoscala and ARTIST programs. The reliability of the hmF2 values obtained by ARTIST and Autoscala was assessed using the corresponding ISR values as a reference. Average errors Δ and the root mean square errors RMSE were computed for the whole dataset. Data analysis shows that both the Autoscala and ARTIST systems tend to underestimate hmF2 values with |Δ| in all cases less than 10 km. For high magnetic activity ARTIST offers better accuracy than Autoscala, as evidenced by RMSE[ARTIST] < RMSE[Autoscala], under both daytime and nighttime conditions, and considering all hours of the day. Conversely, under low and medium magnetic activity Autoscala tends to estimate hmF2 more accurately than the ARTIST system for both daytime and nighttime conditions, when RMSE[Autoscala] < RMSE[ARTIST]. However, RMSE[Autoscala] slightly exceeds RMSE[ARTIST] for the day as a whole. RMSE values are generally substantial (RMSE > 16 km in all cases), which places a limit on the results obtainable with real-time models that ingest ionosonde data.
Structural Changes in Boreal Forests Can Be Quantified Using Terrestrial Laser Scanning
Authors: Yrttimaa Tuomas , Luoma Ville , Saarinen Ninni , Kankare Ville , Junttila Samuli , Holopainen Markus , Hyyppä Juha , Vastaranta Mikko
Published: August 2020

Terrestrial laser scanning (TLS) has been adopted as a feasible technique to digitize trees and forest stands, providing accurate information on tree and forest structural attributes. However, there is limited understanding on how a variety of forest structural changes can be quantified using TLS in boreal forest conditions. In this study, we assessed the accuracy and feasibility of TLS in quantifying changes in the structure of boreal forests. We collected TLS data and field reference from 37 sample plots in 2014 (T1) and 2019 (T2). Tree stems typically have planar, vertical, and cylindrical characteristics in a point cloud, and thus we applied surface normal filtering, point cloud clustering, and RANSAC-cylinder filtering to identify these geometries and to characterize trees and forest stands at both time points. The results strengthened the existing knowledge that TLS has the capacity to characterize trees and forest stands in space and showed that TLS could characterize structural changes in time in boreal forest conditions. Root-mean-square-errors (RMSEs) in the estimates for changes in the tree attributes were 0.99–1.22 cm for diameter at breast height (Δdbh), 44.14–55.49 cm2 for basal area (Δg), and 1.91–4.85 m for tree height (Δh). In general, tree attributes were estimated more accurately for Scots pine trees, followed by Norway spruce and broadleaved trees. At the forest stand level, an RMSE of 0.60–1.13 cm was recorded for changes in basal area-weighted mean diameter (ΔDg), 0.81–2.26 m for changes in basal area-weighted mean height (ΔHg), 1.40–2.34 m2/ha for changes in mean basal area (ΔG), and 74–193 n/ha for changes in the number of trees per hectare (ΔTPH). The plot-level accuracy was higher in Scots pine-dominated sample plots than in Norway spruce-dominated and mixed-species sample plots. TLS-derived tree and forest structural attributes at time points T1 and T2 differed significantly from each other (p < 0.05). If there was an increase or decrease in dbh, g, h, height of the crown base, crown ratio, Dg, Hg, or G recorded in the field, a similar outcome was achieved by using TLS. Our results provided new information on the feasibility of TLS for the purposes of forest ecosystem growth monitoring.
Analyzing Gaps in Hurricane Rain Coverage to Inform Future Satellite Proposals
Authors: Stow Justin P. , Bourassa Mark A. , Holbach Heather M.
Published: August 2020

This study assesses where tropical cyclone (TC) surface winds can be measured as a function of footprint sizes and wavelengths (Ka- Ku- and C-band). During TCs, most high-resolution surface observations are impeded by considerable ‘rain contamination.’ Under these conditions, high-resolution surface observations typically come from operational aircraft. Other techniques that provide high-resolution surface observations through rain are also hindered somewhat by rain contamination and are very sparse in space and time. The impacts of rain are functions of the remotely sensed wavelength and rain–drop size. Therefore, relative long wavelengths have been used to observe the surface, but at the cost of a larger footprint. We examine how smaller footprint sizes could be used to observe through gaps between moderate to heavy rainbands that circulate around the main low-pressure center of a TC. Aircraft data from the National Oceanic and Atmospheric Administration’s (NOAA’s) WP-3D turboprop aircraft will be used to create realistic maps of rain. Our results provide information on the satellite instrument characteristics needed to see the surface through these gaps. This information is expected to aid in developing hurricane-related applications of new higher-resolution satellites.
Construction of the Long-Term Global Surface Water Extent Dataset Based on Water-NDVI Spatio-Temporal Parameter Set
Authors: Han Qianqian , Niu Zhenguo
Published: August 2020

Inland surface water is highly dynamic, seasonally and inter-annually, limiting the representativity of the water coverage information that is usually obtained at any single date. The long-term dynamic water extent products with high spatial and temporal resolution are particularly important to analyze the surface water change but unavailable up to now. In this paper, we construct a global water Normalized Difference Vegetation Index (NDVI) spatio-temporal parameter set based on the Moderate-resolution Imaging Spectroradiometer (MODIS) NDVI. Employing the Google Earth Engine, we construct a new Global Surface Water Extent Dataset (GSWED) with coverage from 2000 to 2018, having an eight-day temporal resolution and a spatial resolution of 250 m. The results show that: (1) the MODIS NDVI-based surface water mapping has better performance compared to other water extraction methods, such as the normalized difference water index, the modified normalized difference water index, and the OTSU (maximal between-cluster variance method). In addition, the water-NDVI spatio-temporal parameter set can be used to update surface water extent datasets after 2018 as soon as the MODIS data are updated. (2) We validated the GSWED using random water samples from the Global Surface Water (GSW) dataset and achieved an overall accuracy of 96% with a kappa coefficient of 0.9. The producer’s accuracy and user’s accuracy were 97% and 90%, respectively. The validated comparisons in four regions (Qinghai Lake, Selin Co Lake, Utah Lake, and Dead Sea) show a good consistency with a correlation value of above 0.9. (3) The maximum global water area reached 2.41 million km2 between 2000 and 2018, and the global water showed a decreasing trend with a significance of P = 0.0898. (4) Analysis of different types of water area change regions (Selin Co Lake, Urmia Lake, Aral Sea, Chiquita Lake, and Dongting Lake) showed that the GSWED can not only identify the seasonal changes of the surface water area and abrupt changes of hydrological events but also reflect the long-term trend of the water changes. In addition, GSWED has better performance in wetland areas and shallow areas. The GSWED can be used for regional studies and global studies of hydrology, biogeochemistry, and climate models.