bluuebunny/crossref_metadata_2025 huggingface dataset:
Morphological, physiological, and biochemical characteristics of Physalis peruviana L. plants under different water availabilities
Authors: Lima Ianna Kamyla Freitas , Nascimento Marilza Neves do , Santana Guimarães David , Santos Neto Francisco dos , Gonçalves Neto Lourival Palmeira
Published: August 2024

Growing Physalis peruviana, which is known for its nutraceutical potential and pleasantly sweet-tasting fruits, can be a profitable economic activity for many small-scale farmers across different regions of Brazil. Therefore, studying its agronomic performance under adverse conditions is necessary, mainly concerning low water availability, which is common during dry periods in semiarid areas in the Northeast region of Brazil. Thus, the objective of this study was to assess the effects of different water availability conditions (20%, 40%, 60%, 80%, and 100% of field capacity - FC) on Physalis peruviana plants. Morphological and physiological characteristics were evaluated: plant height, stem diameter, primary root length, number of leaves per plant, leaf area, relative water content, leaf water potential, and total dry weight. Biochemical analyses were conducted to determine the contents of total soluble proteins, total sugars, reducing sugars, sucrose, and total chlorophyll. Plants subjected to 20% of FC exhibited reduced height, stem diameter, number of leaves, leaf area, relative water content, and leaf water potential due to low soil water availability. Water stress caused an increase in contents of chlorophylls, total soluble proteins, total sugars, reducing sugars, and sucrose.
Phosphate fertilization in processing tomato irrigated by localized irrigation systems
Authors: Silva Cicero José da , Silva Luiz Felipe Mariano da , Neres Jeferson dos Santos , Golynski Adelmo , Pontes Nadson de Carvalho , Moraes Emmerson Rodrigues de , Megguer Clarice Aparecida
Published: August 2024

The aim of this work was to evaluate different combinations of phosphate fertilizer sources on processing tomato (cv. BRS Sena) development and yield, irrigated by localized irrigation systems. The experimental design was in randomized blocks, in split plots, in a factorial scheme (3x5), with four replications. In the plots were used three irrigation systems: drip; subsurface drip and microsprinkler. In the subplots, five combinations of phosphate fertilizer: 100% of Thermophosphate; 100% Triple Superphosphate; 75% Thermophosphate + 25% Triple Superphosphate; 50% Thermophosphate + 50% Triple Superphosphate; and 25% Thermophosphate + 75% Triple Superphosphate. At harvest, the yield of green, ripe and rotten fruits; total yield; percertation of green, ripe and rotten fruits; firmness; pH; titratable acidity; total soluble solids; and fruit size and density were evaluated. Fertilization with Thermophosphate, or its association with Triple Superphosphate, is beneficial for tomato yield. Microsprinkler irrigation provides higher percentage of ripe fruits and lower incidence of green fruits and, when associated with phosphate fertilization of 100% of Thermophosphate, promotes higher yield. Drip and subsurface drip irrigations proved ineffective for the tomato when all the planting fertilization was concentrated in the planting groove. Phosphate fertilization with only Triple Superphosphate was not beneficial the yield, regardless of the irrigation system used. Fertilization with Triple Superphosphate alone or associated with Thermophosphate favored the concentration of maturation, total soluble solids content and tomato fruit acidity.
Experiencias de discriminación étnico-racial, neuroticismo, ira y personalidad oscura: un modelo de mediación serial
Authors: Sánchez-Villena Andy Rick , Temple-Focón Isabella
Published: August 2024

Introducción: Las experiencias de discriminación étnico-raciales son estresores sociales que afectan la salud mental de quienes las sufren. A pesar de que se trata de un fenómeno vigente, los trabajos que han examinado los efectos de la discriminación en la salud mental en Perú y Latinoamérica son escasos. Por ello, el objetivo principal de este estudio es explorar el rol mediador del neuroticismo y la ira en la relación entre las experiencias de discriminación y los rasgos de personalidad oscuros en población peruana. Método: Se contó con la participación de 632 personas con edades de entre 18 y 63 años (M = 25.03; DE = 8.03). Se utilizaron la Escala de Experiencias de Discriminación (EOD), los ítems que miden neuroticismo del Big Five Inventory - 10 (BFI-10), la Escala de Propensión a la Ira (APS - G) y la Dirty Dozen Dark Triad (DDDT). Mediante regresión estructural se creó un modelo explicativo. Resultados: El ajuste del modelo fue excelente (CFI = .975, TLI = .970, RMSEA = .043 y SRMR = .051) y mostró que las experiencias de discriminación tienen un efecto directo sobre el neuroticismo, el cual predice de manera robusta la propensión a la ira, y esta, a su vez, es predictora, en mayor medida, del maquiavelismo, el narcisismo y la psicopatía, respectivamente. Conclusión: El neuroticismo y la ira son mediadores seriados en la relación entre las experiencias de discriminación y los rasgos oscuros de personalidad.
Transformation of Islamic Religious Education in the Context of Multiculturalism at SMA Negeri 9 Yogyakarta Through an Inclusive Approach
Authors: Dwi Afriyanto  , Anatansyah Ayomi Anandari
Published: August 2024

Purpose – This study aims to analyze the transformation of Islamic religious education in SMA Negeri 9 Yogyakarta, including changes in curriculum, teaching methods, and social interaction, to create inclusive and responsive education towards cultural and religious diversity.
Design/methods/approach – This study is qualitative research involving school principals, Islamic teachers, students, and parents of students at SMA Negeri 9 Yogyakarta as research subjects. Data were collected through participatory observation to understand school interactions and document analysis for understanding Islamic curriculum and religious materials.
Findings – The research showed significant results in the transformation of Islamic religious education at SMA Negeri 9 Yogyakarta in the context of multiculturalism. The results revealed the relevant application of inclusive learning methods and Islamic religious education (PAI) materials. It comprised the integration of Quranic verses that emphasize faith and tolerance, as well as the expansion of fiqh material to include aspects of fiqh siyasah that respect ethnic, cultural, and religious diversity. Moreover, moral (akhlaq) learning was focused on understanding good behavior towards various entities, including Allah, Apostles, fellow human beings, oneself, and the environment, which contributed to the formation of the foundations of nationhood. The Islamic Cultural History (SKI) material was also adapted to provide practical examples in a multicultural context. These results confirm that schools have taken concrete steps to adjust Islamic religious education to the needs of a modern multicultural society.
Research implications/limitations – Future research may conduct comparative studies in other schools, evaluate the long-term impact of multicultural approaches, examine the role of communities and parents, develop curriculum and pedagogy, and analyze the role of teachers and school collaboration strategies in supporting multicultural Islamic religious education.
Originality/value – The transformation of Islamic religious education at SMA Negeri 9 Yogyakarta has succeeded in creating an inclusive and harmonious environment amidst religious diversity. This can make a positive contribution to shaping the attitude of tolerance and harmony between religious communities among students.
Innovative Digital Media in Islamic Religious Education Learning
Authors: Septiani Selly Susanti  , Laila Nursafitri  , Iri Hamzah  , Rita Zunarti  , Darmanto  , Fitriyah  , Bima Fandi Asy'arie  , Muhammad Syihab As’ad
Published: August 2024

Purpose – The purpose of this study is to discover and describe the form of innovation in Islamic religious learning that uses digital media/social media as an effective and relevant learning medium in keeping with the demands of technological developments. This study also investigates Islamic Religious Education (PAI) activities in using technology that inspires learning through social media applications.
Design/methods/approach – This study used a literature research method with a qualitative approach. Research data was collected from a variety of sources, including books, scientific journals, proceedings, and other relevant publications. This study used a data analysis paradigm that included data collection, reduction, presentation, and conclusion.
Findings – The researcher obtained five (5) types of social media applications used by PAI teachers. The study is also restricted by vulnerable years limited to 2019-2023. Accordingly, the social media used by PAI teachers in learning have included (1) Tik-Tok (6 journals), (2) YouTube (10 journals), (3) WhatsApp (9 journals), (4) Facebook (6 journals), and (5) Instagram (5 journals) with a total of 36 journals. PAI teachers have played a role in education transformation by utilizing technology as a more interactive, accessible, effective, and compelling learning medium.
Research implications/limitations – The data sources obtained were only limited to online scientific literature. Therefore, the researcher's suggestion for future researchers is to conduct practice field research to allow more accurate results according to the conditions of problems in the field.
Originality/Value – The findings of this study provide an overview of the form of learning innovation that has been carried out in PAI learning with the use of digital media. This finding is also a reference for future researchers to make it easier to find a novelty result.
The New Direction of Indonesian Character Education: Bullying, Moral Decadence, and Juvenile Delinquency
Authors: AB. Musyafa Fathoni  , Mubaidi Sulaeman  , Elima Amiroh Nur Azizah  , Yuslia Styawati  , Mahendra Utama Cahya Ramadhan
Published: August 2024

Purpose – This article aims to provide a new direction for Character Education in minimizing bullying and preventing moral decadence and delinquency in adolescents in the school environment with a Prophetic Parenting approach.
Design/methods/approach – This research used a qualitative method of literature type by collecting literature and data from books, scientific journal articles, yellow books, and Indonesian laws and regulations to reconstruct Character Education in Indonesia that has not been effective in responding to bullying, moral decadency, and juvenile delinquency, using the Prophetic Parenting approach.
Findings – The first thing that the Prophet strongly emphasized in Character Education was a prophetic character, which includes qualities such as siddiq, amanah, tabligh, and fatimah. Second, in character building, following the teachings of the Prophet Muhammad, is important to prioritize the language of deeds rather than words alone. Third, the Prophet Muhammad’s approach taught strong moral and ethical principles. Parents can refer to verses in the Qur'an that emphasize the importance of behaving well, avoiding humility, and humiliating others. Fourth, parents should encourage children to be open about their experiences at school. Fifth, in overall efforts to overcome juvenile delinquency, the Prophetic Parenting approach can be a guide in shaping the character of adolescents with Islamic values and ethics.
Research implications/limitations – The research has theoretical implications that, to minimize the occurrence of bullying, moral decency, and juvenile delinquency, it is necessary to apply parenting that refers to the concept of the Prophet SAW in building the character of Indonesian children toward a golden Indonesia in 2045.
Originality/value – The research provides direction for incorporating the Prophetic Parenting approach into the Indonesian education curriculum in Indonesia to build Character Education that involves the family environment.
BIOREMEDIASI SEBAGAI IMPLEMENTASI Q.S AL-A’RAF AYAT 56 DALAM MENANGANI PENCEMARAN TANAH
Authors: Latifah Lala , Marhayuni Yuni
Published: August 2024

The reduced quality of the soil so that it can no longer function according to its designation is caused by pollution. Soil pollution is a very critical thing at this time, everything we get comes from the soil and returns to the soil. Humans as khalifatullah are given the mandate to maintain and maintain the order of life on earth, including nature. Nature and humans are inseparable units. The interaction between humans and their natural environment can be either positive or negative. Pollution in the environment caused by human activities is one example of negative interactions between humans and nature. Bioremediation is one of the efforts to preserve the nature of God’s creation. In the interpretation of Al-Misbah Q.S Al-A’raf: 56, Allah forbids any damage on earth and orders His servants to guard and maintain it. In bioremediation strategies, environmental improvement can eliminate the risk of long-term damage, in contrast to remediation using chemicals. In addition, the use of bioremediation is easy to implement, inexpensive, and can be implemented anywhere. Based on several studies that have been done, it can be said that bioremediation can reduceharmful compounds in the soil due to pollution.
TINJAUAN FITOREMEDIASI LIMBAH BATIK PEKALONGAN MENGGUNAKAN AGEN ECENG GONDOK (Eichornia crassipes) SEBAGAI IMPLEMENTASI Q. S. AL-BAQARAH AYAT 30
Authors: Khusna Khotimatul , Fatimah Siti
Published: August 2024

Community interest in batik art has increased from time to time, in line with the increase in batik production in Pekalongan. It will impact the waste produced as well. The batik waste without processing causes pollution and environmental damage. Phytoremediation actions can be used as a form of solution to manage the waste pollution. The purpose of this article is to examine the practice of Q. S. Al-Baqarah verse 30 in batik waste by phytoremediation using Water hyacinth (Eichornia crassipes). This article used literature review and self-observation methods to construct the data based on evidence. The review covers 25 journal articles published after 2010 in Bahasa from Goggle Scholar, Research Gate, and Google Books. Based on the results, the phytoremediation of Pekalongan batik waste using water hyacinth can be applied. This is a way of implementing the human mandate as caliph on earth in protecting the environment.
EVALUASI PENERIMAAN DOSIS RADIASI PADA PEKERJA RADIASI DI INSTALASI RADIOLOGI RSUD WONOSARI
Authors: Roo'in Mas'uul Ali , Putro Wahyu Murti Cahyo , Marlina Dina , Budiyono Tris , Handoyo Junaidi Eko
Published: August 2024

Radiation workers, who routinely utilize radiation sources, face a high risk due to prolonged exposure to low doses of radiation. The radiation dose for radiation workers must remain low to not exceed the specified dose limits. The specified dose limits for radiation workers is 20 mSv per year or 100 mSv within 5 years. This study aims to determine the radiation dose outcomes received by radiation workers and their correlation with the number of radiological examinations in the last 5 years at the Radiology Department of RSUD Wonosari. The research was conducted as a quantitative study with a survey approach, and the data were obtained from the receipt of film badge usage reports over a period of five years, as well as data on the number of radiological examinations conducted over the same five-year period in the Radiology Department of RSUD Wonosari. The results of the study indicate that the radiation dose received by radiology personnel at RSUD Wonosari in the last 5 years does not exceed the specified dose limits set by and has a low correlation with the number of radiology examinations conducted in the facility.
The Ecranization of Shichiri Nakayama's Novel Seiren no Zange
Authors: Manuhutu Stefanie Quin , Anwar Fithyani
Published: August 2024

This research aims to explain the ecranization process in the Seiren no Zange novel by Shichiri Nakayama into the Seiren no Zange drama series, as well as to analyze the impact of the ecranization process which includes aspects of reduction, addition and various changes to the story structure in plot, characters, and setting elements. The descriptive qualitative method used in this research is assisted by a structural approach. This research analysis uses the theory of ecranization. Ecranization is a form of transitioning a novel into an audiovisual display as a form of positive response or reaction to a literary work. The data collection regarding this research has been done through literature study and data sources from novels and drama series. In overall, based on the data that have been collected, this ecranization process resulted in 27 reductions, 77 additions and 25 varied changes. The produced data from this research is a form of ecranization of the novel into the Seiren no Zange drama series and the impact of the results of this ecranization.
Communicating through a Scandal: The Case Study of Japan LDP’s Ties with the Unification Church
Authors: Umoro Anisa Ledy
Published: August 2024

The existing literature on political scandals predominantly focuses on their detrimental effects on society at large. This paper aims to offer an alternative perspective, arguing that political scandals can lead to positive change. It does so by examining the case of Japan’s ruling party, the Liberal Democratic Party (LDP) and its ties to the controversial religious organization, the Unification Church (UC). These ties were brought into public attention, following the assassination of the former Japanese Prime Minister, Shinzo Abe. Drawing on the framework of scandal mediation process (Prusa, 2010), this paper defines scandal as a form of communication between the elite and the masses, that facilitated by the media. By consulting data from newspapers and government reports, this paper investigates the progression of the scandal. It highlights how the communication unfolded during the progression of the scandal through public pressure, intense media coverage, public apologies by members of the political elites, and attempts to mitigate the damage. Moreover, this paper argues that the swift response from the government, notably the passing of anti-malicious donation law, shows that a political scandal can positively impact the functioning of social order. Focusing on how and under what circumstance a political scandal may have a positive impact introduces a richer nuance to the discussion of Japanese political scandals as demonstrated by these findings.
ALGEBRAIC STRUCTURES IN HEREDITY HUMAN BLOOD GROUP SYSTEM
Authors: Wasil Moh. , Hartiansyah Fiqih Rahman , Alifia Istianah
Published: August 2024

Marriage or in this case the researcher calls it "cross-operation" between two individuals (male and female) who have the same or different blood type has the probability to produce children (offspring) with the same blood type as one of the parents or even have a completely different blood type with both of them, whether it is the ABO blood type system or MN if it is associated with the rhesus system or not. The cross-operation between two individuals can be viewed from a mathematical perspective as an algebraic structure with one closed binary operation (OB). The cross-operation of ABO blood group system is an algebraic structure in groupoid form. The cross-operation of MN blood group system is an algebraic structure in groupoid form. And finally, the cross-operation of ABO and MN blood group systems when associated with the rhesus blood group system is an algebraic structure in groupoid form.
ANALYSIS OF THE EFFECT OF STUART NUMBER AND RADIATION ON VISCOUS FLUID FLOW
Authors: Anggriani Indira , Norasia Yolanda , Tafrikan Mohamad , Ghani Mohammad , Widodo Basuki
Published: August 2024

Computational fluid dynamics (CFD) is a numerical solution of fluid flow problems built from applied mathematical modeling. The problem of the flow of a viscous fluid which is influenced by a magnetic field gives rise to a boundary layer, from this boundary layer a dimensional building equation is formed. The governing equation is obtained from the continuity equation, momentum equation, and energy equation, then transformed into a non-dimensional equation by substituting non-dimensional variables and transformed into a similarity equation. The numerical solution to this problem uses the Keller Box method. The numerical simulation results show that the Stuart Number increases the velocity profile, while the temperature profile decreases. The effect of radiation parameters on the velocity profile did not change significantly, but the temperature profile decreased.
Edge detection comparative analysis using Roberts, Sobel, Prewitt, and Canny methods
Authors: Utama Kgs Muhammad Rizky Alditra , Umar Rusydi , Yudhana Anton
Published: August 2024

Edge identification in a digital image is overgrowing in line with advances in computer technology for image processing. Edge detection becomes vital in recognizing the object of an image because the edge of the object in the image contains critical information. The information obtained can be either the size or shape of the object in the image, so the edge quality must be good so that the information contained in it is not lost. This study uses edge detection with the Roberts, Sobel, Prewitt, and Canny methods. The assessment method uses visual analysis, PSNR, Histogram, and Contrast. The study shows that the calculation of PSNR on the Roberts method has the highest value, with an average of 44.19 dB. Sobel, Prewitt, and Canny operators have PSNR values above 30 dB to classify it as a good image. The histogram value with the highest value is the Sobel operator, with an average histogram value of 22.06. In contrast, the highest contrast value is the Canny operator has an average contrast value of 5.08. The Roberts and Canny operators have the best image quality.
Large-scale integrated infrastructure for asynchronous microservices architecture
Authors: Ramadhan Insan , Guarddin Gladhi
Published: August 2024

Integrated large-scale business activities increasingly rely on the use of remote resources and services across multi-platform applications. Microservice in previous research has become a solution, but this approach still leaves a data loss problem. This research methodology proposed an architecture of data transmission managed by messaging service to prevent data loss in handling many requests to deliver a multiplatform architecture, handling the plugin services, and enabling escalation based on the requirement. As a result, this research successfully implements large-scale multiplatform Single Sign-On (SSO) infrastructure for asynchronous microservices architecture. The system test results show that the developed system can handle up to 2000 requests with 20 concurrent requests.
Tumor markers determination in malignant pleural effusion: pearls and pitfalls
Authors: Zheng Wen-Qi , Porcel José M. , Hu Zhi-De
Published: August 2024

Serum and pleural fluid tumor markers are well-recognized auxiliary diagnostic tools for malignant pleural effusion (MPE). Here, we discuss some pearls and pitfalls regarding the role of tumor markers in MPE management. The following issues are discussed in this article: What is the appropriate clinical scenario for evaluating pleural tumor markers? Which tumor markers should be advocated for diagnosing MPE? Can extremely high levels of tumor markers be employed to establish a diagnosis of MPE? Does the serum-to-pleural fluid ratio of a tumor marker have the same diagnostic efficacy as the measurement of that marker alone in the pleural fluid? Can tumor markers be used to estimate the risk of specific cancers? What should be considered when interpreting the diagnostic accuracy of tumor markers? How should tumor marker studies be performed? We addressed these issues with published works, particularly systematic reviews and meta-analyses.
Impact of carbonization reactor compartment size on groundnut (Arachis hypogaea) shell biochar properties
Authors: Ayanwusi Oluwatoyin Rhoda , Abdulkareem Sulyman A. , Emmanuel Stephen Sunday , Iwuozor Kingsley O. , Emenike Ebuka Chizitere , Oyewo Opeyemi A. , Adeniyi Adewale George
Published: August 2024

This study investigates the impact of low-temperature top-lit updraft reactor chamber size on GNSBC yield and properties. For this study, the volumes of carbonization chamber (2,364, 2,013, 1,468, and 970 cm3) in a biomass-fueled TLUD biomass gasifier were varied, and the resulting biochar was analyzed using SEM, EDX, and FTIR. The novelty of this work lies in its investigation of the unexplored impact of carbonization reactor compartment size on groundnut shell biochar properties and yield, driven by the need to optimize biochar production efficiency and support sustainable waste management practices. The results showed that carbonization chamber size variation significantly affected GNSBC yield, with an initial increase followed by diminishing returns. An increase in the carbonization compartment size led to decreased carbonization duration, increased carbonization temperature, increased porosity, and decreased oxygen content. SEM analysis revealed consistent amorphous and multi-layered morphological features across BC samples, while EDX analysis confirmed high carbon content in the samples. FTIR spectroscopy confirmed the presence of oxygenated functional groups suitable for pollutant adsorption, supporting GNSBC’s role in environmental remediation and industrial processes. This research contributes to optimizing biochar production efficiency, advancing circular economy goals, and sustainable waste management practices.
Synthesis and characteristics of natural fiber reinforced nano hybrid composite – an experimental study
Authors: Vetrivel Kumar K. , Manikanda Prabu N. , Jayanthi Manju , Gurusamy Sureshkannan
Published: August 2024

Recently, research on natural hybrid composites has occupied a significant role in the materials science sector. Due to the low density, high specific strength, dimensional stability, and biodegradability, natural fiber composite has become a predominant research area. The present study deals with the fabrication of a jute–banana fiber hybrid composite using the hand layup method with compression molding. A fixed concentration of 5 % carbon nanotubes (CNT) is included over the fiber surfaces as an additional reinforcement material to improve their thermal and electrical conduction properties. The prepared composite material is subjected to different fiber loading (0, 10, 20, and 30 wt.%) with jute and banana weight ratios of 1:1, 1:3, and 3:1. The investigation is conducted for testing the physical, mechanical, and thermal properties of the prepared composites along with morphological studies. Final results revealed a maximum longitudinal tensile strength of 68.8 MPa, 67.0 MPa, and 86.7 MPa and the maximum transverse tensile strength of 41.2 MPa, 40.5 MPa, and 48.0 MPa at 30 wt.% with respective fiber ratio of 1:1, 1:3, and 3:1. The maximum longitudinal flexural strength of this hybrid composite is noticed as 94 MPa, 90 MPa, and 103 MPa for the weight ratio of 1:1, 1:3, and 3:1. Higher impact energy is obtained for the composition ratio of 1:3 (JBC 1:3) which has more banana fiber than the other two. A new attempt at adding carbon nanotubes has improved their thermal conductivity compared to regular composites of jute–banana.
Causal Relationship between PECAM-1 Level and Cardiovascular Diseases: A Mendelian Randomization Study
Authors: Sun Mingze , Zhong Yiming , Li Gaoxiang , Zhao Yichao , Zhang Hengyuan , Yang Xiaoqiu , Yan Xiaoxiang , Chen Alex F. , Pu Jun
Published: August 2024

Background:Platelet endothelial cell adhesion molecule (PECAM-1) is present in the vascular endothelium and plays important roles in various biological processes. Several recent studies have reported associations between PECAM-1 and certain subtypes of cardiovascular diseases (CVDs). However, further research is necessary to clarify the causal effects of PECAM-1 on CVDs. To determine whether PECAM-1 and CVDs are causally associated, we conducted a two-sample Mendelian randomization (TSMR) study.

Methods:Single nucleotide polymorphisms (SNPs) associated with PECAM-1 were used as instrumental variants (IVs) to estimate the causal effects of PECAM-1 on CVDs. Six SNPs were included in our TSMR study. The inverse-variance weighted (IVW) method was applied in the primary analysis. To confirm the initial results, we conducted several complementary analyses and pleiotropy analyses.

Results:In the IVW analysis, higher genetically predicted PECAM-1 levels were associated with lower risk of coronary artery disease (CAD) (OR, 0.835; CI, 0.757–0.92; P = 3 × 10−4) and myocardial infarction (MI) (OR, 0.79; CI, 0.709–0.881; P = 2.03 × 10−5).

Conclusions:The findings confirmed that elevated PECAM-1 levels may decrease the risk of CAD and MI. These results confirm the causal effect of PECAM-1 on CVDs and may facilitate further investigation of the mechanism of PECAM-1 in CVD pathogenesis.
DMXL2 is required for endocytosis and recycling of synaptic vesicles in auditory hair cells
Authors: Peng Hu , Wang Longhao , Gao Yunge , Liu Huihui , Lin Guotong , Kong Yu , Xu Pengcheng , Liu Hongchao , Yuan Qingyue , Liu Huanhai , Song Lei , Yang Tao , Wu Hao
Published: August 2024

Ribbon synapses of inner hair cells are uniquely designed for ultrafast and indefatigable neurotransmission of the sound. The molecular machinery ensuring the efficient, compensatory recycling of the synaptic vesicles, however, remains elusive. This study showed that hair cell knockout of murineDmxl2, whose human homolog is responsible for non-syndromic sensorineural hearing loss DFNA71, resulted in auditory synaptopathy by impairing synaptic endocytosis and recycling. The mutant mice in the C57BL/6J background of either sex had mild hearing loss with severely diminished wave-I amplitude of the auditory brainstem response. Membrane capacitance measurements of the inner hair cells revealed deficiency in sustained synaptic exocytosis and endocytic membrane retrieval. Consistent with the electrophysiological findings, 3D electron microscopy reconstruction showed reduced reserve pool of synaptic vesicles and endocytic compartments, while the membrane-proximal and ribbon-associated vesicles remain intact. Our results propose an important role of DMXL2 in hair cell endocytosis and recycling of the synaptic vesicles.

Significance StatementThe molecular basis underlying efficient recycling of the ribbon synaptic vesicles in cochlear hair cells remains elusive. In this study, investigation of a hair cell-specific knockout mouse for Dmxl2 identifies its import roles in endocytosis and recycling of the auditory synaptic vesicles. The mutant mice display auditory synaptopathy, a common feature for noise-induced hearing loss and age-related hearing loss. The inner hair cells show deficiency in sustained synaptic exocytosis and endocytic membrane retrieval with reduced reserve pool of synaptic vesicles and endocytic compartments. Our results provide new insights into the molecular machinery ensuring ultrafast and indefatigable neurotransmission of the sound.
The atmospheric water vapor content effect on carbon dioxide and methane radiative forcing in the troposphere and stratosphere
Authors: ФИРСОВ К.М. , ЧЕСНОКОВА Т.Ю. , РАЗМОЛОВ А.А.
Published: August 2024

Согласно отчету по изменениям климата IPCC-2021 концентрация углекислого газа и метана в атмосфере за последние 50 лет выросла примерно на четверть. Проведены расчеты радиационного возмущающего воздействия (далее – радиационный форсинг) СО2и СН4за счет роста их концентрации для умеренных широт. Вертикальные профили температуры и влажности были взяты согласно данным аэрологического и спутникового зондирования атмосферы. Статистическими методами исследовано влияние перекрывания полос поглощения Н2О с полосами CО2и CH4на результаты расчета радиационного форсинга этих газов в тропосфере и стратосфере умеренных широт при различном содержании водяного пара. Показано, что радиационный форсинг CO2в тропосфере с ростом влагосодержания возрастает по абсолютной величине, тогда как радиационный форсинг СН4не зависит от общего влагосодержания в вертикальном столбе атмосферы. Полученные результаты могут представлять интерес для специалистов, изучающих процессы динамики паров воды в атмосфере и их взаимосвязи с ростом концентрации парниковых газов.

According to the IPCC-2021 Report on climate change, the atmospheric CO2and CH4concentrations have increased by around a quarter for the last 50 years. The CO2 and CH4radiative forcing due to their concentration growth was calculated for mid-latitudes. The vertical profiles of temperature and humidity were taken from the ECMWF ERA-5 European reanalysis data. An impact of overlapping of H2O absorption bands with CO2and CH4bands on the radiative forcing calculation results in the troposphere and stratosphere of mid-latitudes with different water vapor content was investigated by statistical methods. It was shown that absolute value of the CO2 radiative forcing in the troposphere increases with the atmospheric water vapor content, whereas the CH4radiative forcing does not depend on the atmospheric total column water vapor.
The memoires about Vaclovas Biržiška
Authors: Žukas Vladas
Published: August 2024

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The Departments of Library Science and Book Science in 1996
Authors: Kastanauskaitė Danutė
Published: August 2024

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Lithuanian books in the libraries of monasteries (end of XVIII - beginning of XIX century)
Authors: Pacevičius Arvydas
Published: August 2024

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Electronic publishing and the future ofthe book
Authors: Wilson Tom D.
Published: August 2024

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Publishers, authors and readers: the right to read in a digital age
Authors: Valauskas Edward J.
Published: August 2024

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First record of a breeding site of Ara militaris mexicanus (Ridgway, 1915), Military Macaw (Psittacidae), in the Alto Balsas Poblano Region, Mexico
Authors: Vázquez-Reyes Leopoldo Daniel , Jiménez-Arcos Víctor Hugo , Ramírez-Bastida Patricia , Rodríguez-Malacara Jorge Tanit , Contreras-González Ana María , Sanabria-Urban Oscar Salomón , Rivera-Ortiz Francisco Alberto
Published: August 2024

We report a new breeding site of Ara militaris mexicanus (Ridway, 1915), Military Macaw, in the state of Puebla in the Alto Balsas river basin, Mexico. The breeding site is in the Cañón Grande area along the Nexapa River. Observed temporality and breeding behaviors agree with the recorded breeding season of this species in Central Mexico. Notably, the region has no current designation as a protected natural area for conservation. We recommend collaboration with the local community to initiate efforts towards designate the Alto Balsas river basin as a protected natural area.
Justification of the feasibility of improving intersectoral interaction in order to preserve the ophthalmological health of children in Ukraine
Authors:   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Antipkin Yu.G. , Medvedovska N.V. ,   National Academy of Medical Sciences of Ukraine, Kyiv, Denysiuk L.I. ,   Shupyk National Healthcare University of Ukraine, Kyiv,   Kyiv City Clinical Ophthalmological Hospital "Eye Microsurgery Center", Ukraine, Bondarenko N.Yu. ,   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Miroshnikov O.O. ,   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv
Published: August 2024

Changing conditions and modern features of the transformation of society require the full functioning of the visual analyzer. Healthy vision in childhood becomes the key to the formation of a harmonious personality, components of the child's physical and psycho-emotional development during growth. The aim is to justify the feasibility of improving the system of preserving the ophthalmological health of children in Ukraine with the introduction of intersectoral systemic interaction of medical and educational workers who work with children on a daily basis. Materials and methods. For the scientific justification of the feasibility of improving the system of preserving the ophthalmological health of children in Ukraine, the results of sociological research among doctors and educators who work daily with children of different ages, modern analytical materials summarizing the recommendations of the World Health Organization regarding the medical and social aspects of the occurrence of disorders were applied visual functions in children of different ages. Research methods: system approach and system analysis; analytical and synthetic; structural analysis; sociological research, SWOT analysis and graphic modeling. Results and conclusions. The expediency of improving intersectoral interaction in order to preserve the ophthalmological health of children in Ukraine has been proven, the model of which, as well as the main structural elements, is detailed in the work. Modern components, the implementation of which is proposed to be started at the regional level, are: leadership and strategic management on the ground; financing with improvement of the economic principles of interaction of primary medical care institutions; personnel support for the provision of preventive services for the preservation of ophthalmic health; informational and educational work. The well-founded model takes into account the need to improve the functional and organizational components of the availability of children's ophthalmic care, material and technical, personnel support to increase the effectiveness of medical and preventive ophthalmic care for children, as well as the effectiveness of engaging interdisciplinary initiatives in optimizing the diagnosis of vision disorders in children. The authors declare no conflict of interest.
The condition of newborns and the course of the early neonatal period in children from mothers who had complications from the group of great obstetric syndromes
Authors:   State higher educational institution “Uzhhorod National University”, Ukraine, Lemish N.Y. , Bobik Yu.Yu. ,   State higher educational institution “Uzhhorod National University”, Ukraine
Published: August 2024

Aim of research - to study the peculiarities of the course of the antenatal and early postnatal period in children from mothers who had complications from the group of great obstetric syndromes (GOS), in order to improve the algorithm of their management. Materials and methods. 239 newborns from pregnant women (the main group - MG) who had complications from the group of GOS, were examined. The control group (CG) consisted of newborns from 56 almost healthy pregnant women with a good reproductive history and an uncomplicated course of this pregnancy. Statistical processing of research results was carried out using standard Microsoft Excel 5.0 and Statistical 6.0 programs. Results. Newborns in the CG were significantly smaller in all anthropometric indicators compared to newborns in the CG, fetal growth restriction syndrome was observed in 41 (17.2%) newborns in the CG, while absent in CG. The condition of newborns according to the Apgar scale in 180 (75.3%) children of MG ranged from 5 to 7 points, >7 - in 59 (24.7%) (average value - 6.8±0.91), in CG - 7 ,9±0.73, at 5 minutes in 212 (88.7%) newborns >7 points. In the MG, 81 (33.9%) children were born in a state of asphyxia, which led to hypoxic-ischemic injury of the central nervous system in 54 (22.5%) newborns from mothers in the MG. Increased nerve excitability, small-scale tremor, horizontal nystagmus and low muscle tone were observed in 26 (10.8%) children, and generalized weakness - in 14 (5.9%) children from MG and 2 (3.6%) children from CG. Conclusions. The conducted study showed that children born to mothers with clinical manifestations of GОS (premature birth, placental insufficiency, preeclampsia) have a high incidence of complications in the antenatal and early neonatal period, in particular, fetal growth restriction syndrome, distress in childbirth, asphyxia, hypoxic-ischemic injury to the central nervous system, conjugation jaundice, respiratory distress syndrome, as well as weight loss in newborns. The research carried out in accordance with principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of the institution indicated in the work. The informed consent of women was obtained for conducting the studies. No conflict of interests was declared by the authors.
Comorbidity and impact of bronchial asthma to gastroesophageal reflux disease in children
Authors:   Kharkiv National Medical University, Ukraine, Кarpushenko Y.V. , Frolova Т.V. ,   Kharkiv National Medical University, Ukraine, Drobova N.M. ,   Kharkiv National Medical University, Ukraine, Ashcheulov О.М. ,   Kharkiv National Medical University, Ukraine
Published: August 2024

Gastroesophageal reflux disease (GERD) is a highly comorbid disease with bronchial asthma (BA). The relationship between GERD and BA is complicated and controversial. Aim: to analyze impact factors of BA and GERD in children with comorbid pathology for the further development of early diagnostic and preventive measures. Materials and methods. 81 children (aged 6 to 18 years) were involved in the study and divided into two groups: children with GERD and BA as a main group (n=27) and children with GERD and without allergy as a control group (n=54). The verification of diagnoses was carried out according to the unified clinical protocols of medical care. The results were processed using nonparametric statistical methods. Results. Esophageal motility disorders (EM) were detected in 100% of patients with BA, regardless of the severity. Inflammatory changes of the esophageal mucosa (EM) were equally frequently detected in patients with mild and moderate persistent BA, and were absent in patients with severe BA. GERD was diagnosed in 44.4% of patients with BA. 25.0% of patients had the erosive form of GERD, 25.0% - non-erosive GERD, 50.0% - endoscopically negative GERD, in the control group - 33.0%, 35.0%, 32.0% respectively. Conclusion. All patients with BA had esophageal motility disorders. GERD was diagnosed in 44.4%. Inflammatory changes of EM (erosive and non-erosive forms of GERD) were detected in 22.0% of patients with mild and moderate forms of BA, and in severe forms of BA - endoscopically negative GERD. The frequency of inflammatory changes reached 68.0% in the control group. The research was carried out in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Local Ethics Committee of the institution indicated in the work. The informed consent of children's parents was obtained for conducting the studies. No conflict of interests was declared by the authors.
Specifics of clinical manifestations of post-COVID-19 syndrome in children
Authors:   SI ", Petritsa N.A. ,   Institute of Hereditary Pathology NAMS of Ukraine",   , Lviv, Ukraine, Lukyanenko N.S. ,   SI "Institute of Hereditary Pathology NAMS of Ukraine", Lviv, Ukraine,   Danylo Halytsky Lviv National Medical University, Ukraine, Kech N.R. ,   SI "Institute of Hereditary Pathology NAMS of Ukraine", Lviv, Ukraine,   Danylo Halytsky Lviv National Medical University, Ukraine
Published: August 2024

Coronavirus disease 2019 (COVID-19) and its long-term consequences have a significant negative impact on the lives of people around the world. The long-term consequences of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection are known as the post-COVID-19 syndrome, the symptoms of which can persist for more than 12 weeks after the onset of the disease. Despite the measures already taken to control and combat the disease, the problem of establishing the structure of post-COVID-19 syndrome, especially in children, remains an important global problem for society. Aim - to determine the data on the structure of the incidence of children with post-COVID-19 syndrome. Materials and methods. We examined 505 children under 18 years of age with post-COVID-19 syndrome who were inpatients during January-July 2023. The source of information was the medical record of an inpatient (Form 003/O). The study was conducted by randomization. All sick children underwent a comprehensive clinical and laboratory examination in accordance with standard, generally accepted methods of clinical, laboratory and instrumental examination in pediatrics. Statistical processing was performed in the EZR program package (R-statistics). Results. It was established that in children with post-COVID-19 syndrome, the smallest number were children under 3 years old (12.87%), and the largest number were children from 12 to 18 years old (31.69%). In children with post-COVID-19 syndrome, the most commonly affected sensory (80.20%) and nervous (78.61%) systems were noted. Conclusions. The lesions of the nervous and sensory systems in children with post-COVID-19 syndrome are explained by the comorbidity of SARS-CoV-2 tropism to these systems and a sharp deterioration in the socioeconomic and psycho-emotional state of children with post-COVID-19 syndrome. The distribution of the examined children by gender and age simultaneously revealed a progressive increase in the frequency of male children with post-COVID-19 syndrome with increasing age. Identification of a combination of these factors in children may increase pediatricians' alertness to the occurrence of post-COVID-19 syndrome in children and will facilitate timely correction and diagnosis of post-COVID-19 syndrome. The study was conducted in accordance with the principles of the Declaration of Helsinki. The study protocol was approved by the Local Ethics Committee of all the institutions mentioned in the work. Informed consent of parents and children was obtained for the study. The authors declare no conflict of interest.