bluuebunny/crossref_metadata_2025 huggingface dataset:
Golgi Analysis of Neuron Morphology in the Presumptive Somatosensory Cortex and Visual Cortex of the Florida Manatee (Trichechus manatus latirostris)
Authors: Reyes Laura D. , Harland Tessa , Reep Roger L. , Sherwood Chet C. , Jacobs Bob
Published: May 2016

The current study investigates neuron morphology in presumptive primary somatosensory (S1) and primary visual (V1) cortices of the Florida manatee (Trichechus manatus latirostris) as revealed by Golgi impregnation. Sirenians, including manatees, have an aquatic lifestyle, a large body size, and a relatively large lissencephalic brain. The present study examines neuron morphology in 3 cortical areas: in S1, dorsolateral cortex area 1 (DL1) and cluster cortex area 2 (CL2) and in V1, dorsolateral cortex area 4 (DL4). Neurons exhibited a variety of morphological types, with pyramidal neurons being the most common. The large variety of neuron types present in the manatee cortex was comparable to that seen in other eutherian mammals, except for rodents and primates, where pyramid-shaped neurons predominate. A comparison between pyramidal neurons in S1 and V1 indicated relatively greater dendritic branching in S1. Across all 3 areas, the dendritic arborization pattern of pyramidal neurons was also similar to that observed previously in the afrotherian rock hyrax, cetartiodactyls, opossums, and echidnas but did not resemble the widely bifurcated dendrites seen in the large-brained African elephant. Despite adaptations for an aquatic environment, manatees did not share specific neuron types such as tritufted and star-like neurons that have been found in cetaceans. Manatees exhibit an evolutionarily primitive pattern of cortical neuron morphology shared with most other mammals and do not appear to have neuronal specializations for an aquatic niche.
Outcomes of IgA Nephropathy with Segmental Glomerular Necrosis But without Crescent Formation
Authors: Tan Min , Li Wenge , Zou Guming , Zhang Cong , Fang Jing
Published: May 2016

Background: The significance of segmental glomerular necrosis (SGN) was not evident in immunoglobulin A nephropathy (IgAN) patients. Especially, there were a number of patients who presented with slight histopathological damage except SGN. We, therefore, conducted a study to highlight the occurrence of these cases and to define their clinical characteristics and outcomes at our centre. Methods: The clinical, laboratory and pathological manifestations and outcomes of these IgAN patients were collected and compared with IgAN patients with simily histopathological background but without SGN. Survival curves were constructed according to the Kaplan-Meier method. Multivariate Cox regression analysis was used to identify independent factors for the development of endpoint. Results: Eighty-two patients with SGN but without crescents were found in Haas grades I-III. Macroscopic hematuria and prodromal infection were more popular and the mean daily proteinuria was significantly higher in patients with SGN. More patients had high serum IgA in the ecrotizing IgAN group. At last follow-up, there were no differences in hypertension, proteinuria, serum creatinine, estimated GFR and the incidence of end-point events between 2 groups. SGN was not an independent predictor for the prognosis of IgAN. Corticosteroid treatment could decrease proteinuria significantly. The outcomes of the 2 populations of necrotizing IgAN patients with or without corticosteroid treatment were not different. Conclusions: SGN can be found in mild pathological damage patients and is not always associated with crescent formation. Heavier proteinuria was found in these IgAN patients. SGN was not an independent predictor for the prognosis of IgAN.
Long-Term Survival Following Traumatic Brain Injury: A Population-Based Parametric Survival Analysis
Authors: Fuller Gordon W. , Ransom Jeanine , Mandrekar Jay , Brown Allen W.
Published: May 2016

Background: Long-term mortality may be increased following traumatic brain injury (TBI); however, the degree to which survival could be reduced is unknown. We aimed at modelling life expectancy following post-acute TBI to provide predictions of longevity and quantify differences in survivorship with the general population. Methods: A population-based retrospective cohort study using data from the Rochester Epidemiology Project (REP) was performed. A random sample of patients from Olmsted County, Minnesota with a confirmed TBI between 1987 and 2000 was identified and vital status determined in 2013. Parametric survival modelling was then used to develop a model to predict life expectancy following TBI conditional on age at injury. Survivorship following TBI was also compared with the general population and age- and gender-matched non-head injured REP controls. Results: Seven hundred and sixty nine patients were included in complete case analyses. The median follow-up time was 16.1 years (interquartile range 9.0-20.4) with 120 deaths occurring in the cohort during the study period. Survival after acute TBI was well represented by a Gompertz distribution. Victims of TBI surviving for at least 6 months post-injury demonstrated a much higher ongoing mortality rate compared to the US general population and non-TBI controls (hazard ratio 1.47, 95% CI 1.15-1.87). US general population cohort life table data was used to update the Gompertz model's shape and scale parameters to account for cohort effects and allow prediction of life expectancy in contemporary TBI. Conclusions: Survivors of TBI have decreased life expectancy compared to the general population. This may be secondary to the head injury itself or result from patient characteristics associated with both the propensity for TBI and increased early mortality. Post-TBI life expectancy estimates may be useful to guide prognosis, in public health planning, for actuarial applications and in the extrapolation of outcomes for TBI economic models.
A Familial 14q32.32q32.33 Duplication/17p13.3 Deletion Syndrome with Facial Anomalies and Moderate Intellectual Disability
Authors: He Chunxia , Dong Changhu , Li Jingyi , Hu Depin , Yao Libo , Wu Yuanming
Published: May 2016

To our knowledge, a derivative chromosome 17 formed by a subtelomeric translocation involving chromosomes 17 and 14 has not been reported before. Here, we present the clinical and molecular cytogenetic characteristics of 2 family members with a subtelomeric rearrangement involving chromosome regions 14q32.32q32.33 and 17p13.3. The patients had moderate intellectual disability, a high forehead, a broad nasal root, downslanting palpebral fissures, epicanthal folds, retrognathia, hypertelorism, wrinkled skin over the glabella and metopic suture, and mild finger clubbing. Array CGH detected a 2.52-Mb duplication of 14q32.32q32.33 (103,805,680-106,396,479) and a 1.2-Mb deletion of 17p13.3 (87,009-1,298,869) confirmed to be pathogenic by quantitative PCR and loss of heterozygosity analysis of 17p13.3. The derivative chromosome 17 was inherited from a parental balanced translocation. To our knowledge, this cytogenetic aberration has not been described previously. The refinement of the genetic location will improve the knowledge of the genes responsible for this phenotype.
Endoplasmic Reticulum Stress Predicts Clinical Response to Cyclosporine Treatment in Primary Membranous Nephropathy
Authors: Tao Jianling , Zhang Wei , Wen Yubing , Sun Ying , Chen Limeng , Li Hang , Li Mingxi , Li Xuewang , Lafayette Richard A. , Li Xuemei
Published: May 2016

Background: Little is known about the endoplasmic reticulum stress (ERS) marker glucose regulated protein 78 (GRP78) and calcineurin in the kidney in primary membranous nephropathy (PMN) and if they could predict post-cyclosporine treatment outcome. Methods: This is a retrospective study using a dataset of biopsy-confirmed PMN from Peking Union Medical College Hospital from 1996 to 2014. Seventy-six adult patients treated with cyclosporine as primary immunosuppression for at least 6 months were studied. Immunohistochemistry was used to detect GRP78 and calcineurin in the kidney. Serum calcineurin was assayed by ELISA. Patients were grouped into no-remission (NR, n = 17), partial remission (PR, n = 39), or complete remission (CR, n = 20) at the end of 6 months of treatment. Results: There was no difference of initial dose of cyclosporine among NR, PR, and CR groups. Kidney calcineurin expression in PMN was significantly increased compared to that in controls (p < 0.0083). The glomerular GRP78 in NR PMN was higher than that in control, CR and PR patients (p < 0.0083). Kidney calcineurin expression and GRP78 expression was positively correlated. However, there were no differences in either serum calcineurin levels or kidney calcineurin expressions among NR, PR or CR groups. There was a negative correlation between serum calcineurin activity and whole kidney calcineurin expression (p = 0.034) or glomerular calcineurin expression (p = 0.007). Neither kidney calcineurin nor GRP78 expression was correlated with proteinuria. Conclusions: ERS marker GRP78 in the glomeruli but not serum or kidney calcineurin expression could be a useful marker in PMN to negatively predict the response to cyclosporine treatment at the sixth month.
Platelet Gel in a Non-Regenerating Cryosurgery-Induced Skin Wound in an Old Patient: A Case Report
Authors: Pignalosa Orlando , Martusciello Dario , De Pascale Maria R. , Sommese Linda , Nicoletti Giovanni F. , Itro Angelo , Cavalca Francesco , Tartaro Gianpaolo , Napoli Claudio
Published: May 2016

Objective: To report on the clinical benefits of platelet gel application in a non-regenerating skin wound. Clinical Presentation and Intervention: An 84-year-old man presented with a severe wound with a regular circumference in the frontal region which resulted in a complete loss of epidermis and dermis. The skin lesion, induced by cryosurgery used to remove a basal-cell carcinoma, had previously been treated with a dermal substitute application (Integra®). After the failure of the skin graft, the patient was treated using a platelet gel therapeutic protocol which achieved the complete healing of the injured area. Conclusion: This case showed the clinical efficacy of using platelet gel in this elderly patient in whom the dermal substitute graft had been ineffective.
Plasma Glycated Albumin Levels Clearly Detect Hearing Loss and Atherosclerosis in Patients with Impaired Fasting Glucose
Authors: Ezerarslan Hande , Çandar Tuba , Özdemir Sedat , Ataç Gökçe Kaan , Kocatürk Sinan
Published: May 2016

Objective: To describe the relationship between atherosclerosis and hearing thresholds in prediabetic patients with impaired fasting glucose (IFG) and to determine the efficacy of glycated albumin in predicting carotid artery atherosclerosis in patients with isolated IFG. Subjects and Methods: The study included 82 patients (aged 53.73-80 years) divided into two groups based on fasting glucose levels, the IFG group: 59 patients (32 females, 54.2%), and the normal fasting plasma glucose level group: 23 patients (12 females, 52.2%). Patients underwent audiological testing to determine hearing thresholds, and carotid intima-media thickness (CIMT) was measured using carotid artery Doppler sonography. Multivariate analyses were performed to determine whether or not the plasma glycated albumin levels could predict hearing loss and CIMT. Results: Patients in the IFG group (mean age: 59.8 ± 9.5 years) had higher hearing thresholds and pure-tone average scores (PTA) than those in the group with normal glucose levels (mean age: 56.2 ± 10.1 years) (left ear: 27.65 ± 8.85 vs. 25.75 ± 21.96 dB, p = 0.021; right ear: 29.22 ± 8.51 vs. 22.39 ± 6.99 dB, p = 0.001). The CIMT was significantly higher in the IFG group than the control group (0.75 ± 0.26 vs. 0.56 ± 0.16 mm, p < 0.001 for the left and 0.74 ± 0.26 vs. 0.51 ± 0.19 mm, p < 0.001 for the right carotid arteries). Glycated albumin levels were independently related with increased CIMT (left CIMT: r = 0.32, p = 0.003; right CIMT: r = 0.42, p < 0.001), and serum glycated albumin levels were significantly associated with PTA (left ear: r = 0.28, p = 0.01; right ear: r = 0.30, p = 0.006). Conclusion: Sensorineural hearing loss was more common in patients with IFG. Plasma glycated albumin levels were strongly correlated with CIMT and carotid plaques as a marker of atherosclerosis and with hearing impairment thought to develop due to atherosclerosis in patients with IFG.
Factors Influencing Dental Patient Participation in Biobanking and Biomedical Research
Authors: Hassona Yazan , Ahram Mamoun , Odeh Noorah , Abu Gosh Mais , Scully Crispian
Published: May 2016

Objectives: To study the willingness of dental patients to donate biospecimens for research purpose and to examine factors that may influence such a decision. Materials and Methods: A face-to-face interview was conducted using a pretested structured survey instrument on 408 adult dental patients attending a university hospital for dental care. Descriptive statistics were generated, and the χ2 test was used to examine differences between groups. p values ≤0.5 were considered statistically significant. Results: Of the 408 participants, only 71 (17.4%) had heard of the terms biobanking/biospecimens, but 293 (71.9%) approved of the idea of using biospecimens for biomedical research, and 228 (55.9%) were willing to donate biospecimens and give personal information for research purposes. In participants who were unwilling to participate in biobanking, fear of information leakage was the most frequently reported reason, while in participants who were willing to donate biospecimens, the potential to provide more effective and less costly treatments was the most frequently reported reason. The preferences of the 228 participants who were willing to donate biospecimens were as follows: give a sample of removed oral tissues including extracted teeth (n = 105, 46.1%), donate a blood sample (n = 52, 23%), donate a sample of saliva (n = 43, 18.6%), and give a urine sample (n = 28, 12.3%). Conclusion: Dental patients had a generally positive attitude towards biomedical research and biobanking. The most preferred types of biospecimens to donate in a dental setting were removed tissues, including extracted teeth and blood samples.
БІОФІЗИЧНА ХАРАКТЕРИСТИКА ВОЛОГИ ПОВІТРЯ, ЩО ВИДИХАЄТЬСЯ, У ХВОРИХ НА ТУБЕРКУЛЬОЗ ЛЕГЕНЬ У ДИНАМІЦІ ЛІКУВАННЯ
Authors: Bazhora Yu. I. , Yermuraki P. P. , Chesnokova M. M. , Smetyuk O. O. , Abdulrakhman Ali Sleman Sayeb
Published: May 2016

Волога повітря, що видихається, привертає увагу як матеріал для вивчення біологічних компонентів. Пов'язано це з тим, що конденсат вологи повітря, що видихається (КВВП), формується в альвеолах легеневої тканини і його складові відображають стан місцевого гомеостазу системи дихання. Крім того, метод отримання КВВП належить до неінвазивних, що також привертає увагу
дослідників.
У попередніх дослідженнях нами була показана діагностична цінність методу лазерної кореляційної спектроскопії (ЛКС) у дослідженнях біофізичних властивостей КВВП при захворюваннях органів дихання.
ОСОБЛИВОСТІ КОРЕКЦІЇ ПОКАЗНИКІВ ЧЕРВОНОЇ КРОВІ ПРИ ХРОНІЧНИХ ЮВЕНІЛЬНИХ АНОМАЛЬНИХ МАТКОВИХ КРОВОТЕЧАХ
Authors: Dobryansʹka V. Yu. , Bahniy L. V. , Heryak S. M. , Yakymchuk V. D. , Kolochun H. V. , Bahniy N. I. , Mavdrik Z. Ya. , Khinochyk V. M.
Published: May 2016

Аномальні маткові кровотечі у підлітковому періоді, за даними літератури, складають понад 20 % усіх гінекологічних захворювань дівчаток.
Тривала чи значна за об’ємом менструація призводить до розвитку залізодефіцитної анемії як крайнього ступеня прояву дефіциту депонованого заліза. Тому сучасні принципи лікування аномальних маткових кровотеч ювенільного віку мають на меті зупинку кровотечі (гемостатиками, гормональний чи хірургічний гемостаз), її профілактику шляхом нормалізації менструального циклу, в тому числі відновлення депо заліза і рівня гемоглобіну в крові. У кожному разі появи кровотеч у підлітковому віці, їх лікування та спостереження повинно розпочинатися в умовах стаціонару.
ХАРЧУВАННЯ ХВОРИХ З УРАЖЕННЯМ ЖОВЧНОГО МІХУРА НА ФОНІ ОЖИРІННЯ З УРАХУВАННЯМ КОМПОНЕНТНОЇ БУДОВИ ТІЛА ТА ЛІПІДНОГО ОБМІНУ
Authors: Matyukha L. F. , Yakubovsʹka I. A.
Published: May 2016

Харчування є одним з основних факторів, який визначає стан здоров’я людини та впливає на розвиток захворювань. На даний час метаболічний синдром (МС) виявляють у 25 % дорослого населення планети,
серед осіб віком понад 60 років – у 45 %, до того ж, за останні роки відзначається стійке зростання розвитку МС серед молоді. Відомо, що МС супроводжується метаболічним ураженням печінки, а також є фактором ризику розвитку ураження біліарної системи – холестеринового холелітіазу, холестерозу жовчного міхура. Збільшення частоти обмінних уражень жовчного міхура асоціюється зі зростанням захворюваності на ожиріння, метаболічного синдрому, цукрового діабету. Патологія жовчовивідних шляхів займає одне з чільних місць у гастроентерології, а дисфункція жовчного
міхура (ЖМ) зустрічається у кожної п'ятої дорослої людини. Численні дослідження свідчать про те, що хронічний холецистит та дисфункції ЖМ
асоціюються з порушеннями холесекреторної функції печінки.
РАННІ МАРКЕРИ СИСТЕМНОГО АТЕРОСКЛЕРОЗУ У ХВОРИХ МОЛОДОГО ВІКУ, ЯКІ ПЕРЕНЕСЛИ ГОСТРИЙ ІНФАРКТ МІОКАРДА
Authors: Mykulyak V. R. , Zorya L. V. , Trach N. I.
Published: May 2016

На сьогоднішній день доведено, що товщина комплексу інтима-медіа (КІМ) – важливий предиктор розвитку серцево-судинної та церебральної патології.
Дослідження мікрофлори лунки після атипового видалення нижніх третіх молярів при застосуванні остеопластичного матеріалу «Колапол КП-3 ЛМ»
Authors: Nahirniy Ya. P. , Oshchypko R. V. , Piasetska L. V.
Published: May 2016

Results of the study of influence osteoplastic material «Kolapol KP-3 LM» on the microbial landscape of fluid from wells after the removal of lower third molars have given in this article. The results show the most pronounced effect on flora, that potentially can be the causative agent of purulent inflammation.
Клінічні прояви гострих респіраторних вірусних інфекцій
Authors: Hevkalyuk N. O.
Published: May 2016

Dynamic monitoring of patients with influenza, parainfluenza, adenovirus disease revealed that when these changes are infections of the oral mucosa in the form of hemorrhages, vascular enhanced figure, edema, granularity, plaque, desquamation of the epithelium of the tongue. Oral mucosa damaged in all forms of the disease, but these changes were not strictly specific nature, their severity was determined by the severity of occurrence of ARVI.
Методологія впровадження навчального посібника «Технологічні аспекти виготовлення ортопедичних конструкцій» у навчальний процес із вибіркової дисципліни
Authors: Hasiuk P. A. , Korol D. M. , Rosolovska S. O. , Korobeynikov L. S. , Radchuk V. B. , Kozak R. V.
Published: May 2016

The methods of development and elaboration of standard selective training discipline «The basic technologies of dentures construction” according to the European Credit Tranter System have been shown in the article. The specific objectives of discipline study in the form of particular professional skills required for corresponding thematic modules have been formulated. The means of students’ preparation level evaluation and recommended control forms have been revealed with the help of the textbook “Technological aspects of the manufacture of orthopedic structures».
Memórias Interioranas: Campo e Cidade através do Rádio numa Comunidade Ribeirinha Amazônica
Authors: Macedo Catia Oliveira , Costa Antonio Mauricio Dias da
Published: May 2016

Os programas de rádio têm desempenhado um importante papel na troca comunicacional entre os diversos pontos da Região Amazônica desde a década de 1940. Na memória dos moradores mais antigos da comunidade da Foz do Cravo, localizada à margem do Rio Bujaru, na Amazônia Oriental, a lembrança dos programas de rádio mobiliza representações acerca do modo de vida na cidade e no interior. Elas são elaboradas como referências simbólico-espaciais, engendradas a partir de experiências de recepção e interação com programas de rádio, muito ouvidos na localidade entre os anos 1960 e 1980. O levantamento preliminar das percepções sócio espaciais sobre a Amazônia através de programas de rádio, como no caso em foco, é revelador de formas de compreensões nativas da organização espacial vivida pelos sujeitos da memória.
Corporeidade, sexualidades no mercado sexual transnacional sob o olhar eurocêntrico
Authors: Silva Joseli Maria , Ornat Marcio Jose
Published: May 2016

O objetivo do artigo é compreender como a corporeidade e sexualidade das brasileiras é produzida sob o olhar hegemônico eurocêntrico, bem como a capacidade subversiva das prostitutas, no processo de mobilidade espacial, em desenvolver estratégias capazes de tirar vantagens de uma estrutura de forte exclusão e vulnerabilidade, contemplando uma perspectiva interseccional entre classe, gênero e raça. Para atingir tal objetivo foram realizadas quatorze entrevistas em profundidade com mulheres brasileiras profissionais do sexo, moradoras da Espanha, com idade entre vinte e três e trinta anos e seis entrevistas com homens espanhóis com idade entre trinta e cinco e sessenta e dois anos, assíduos frequentadores de locais em que se desenvolvem atividades de comércio sexual.
Fama, pasión y razón en la carta de Monterrey de Sor Juana Inés de la Cruz
Authors: Colombi Beatriz
Published: May 2016

Este trabajo analiza la carta de Monterrey (1682) de sor Juana Inés de la Cruz, antecedente de la Respuesta a sor Filotea, como un discurso de la intimidad construido lejos de la administración que ejerce la retórica clásica; en su lugar emerge una gramática de las pasiones, donde la antítesis barroca crea tensión permanente, entre la pasión y la razón, el silencio y la confesión, la fama literaria y la comunidad.
Pulmonary Vein Antrum Isolation in Patients With Paroxysmal Atrial Fibrillation
Authors: Gökoğlan Yalçin , Mohanty Sanghamitra , Güneş Mahmut F. , Trivedi Chintan , Santangeli Pasquale , Gianni Carola , Asfour Issa K. , Bai Rong , Burkhardt J. David , Horton Rodney , Sanchez Javier , Hao Steven , Hongo Richard , Beheiry Salwa , Di Biase Luigi , Natale Andrea
Published: May 2016

Background—

We report the outcome of pulmonary vein (PV) antrum isolation in paroxysmal atrial fibrillation (AF) patients over more than a decade of follow-up.

Methods and Results—

A total of 513 paroxysmal AF patients (age 54±11 years, 73% males) undergoing catheter ablation at our institutions were included in this analysis. PV antrum isolation extended to the posterior wall between PVs plus empirical isolation of the superior vena cava was performed in all. Non-PV triggers were targeted during repeat procedure(s). Follow-up was performed quarterly for the first year and every 6 to 9 months thereafter. The outcome of this study was freedom from recurrent AF/atrial tachycardia. At 12 years, single-procedure arrhythmia-free survival was achieved in 58.7% of patients. Overall, the rate of recurrent arrhythmia (AF/atrial tachycardia) was 21% at 1 year, 11% between 1 and 3 years, 4% between 3 and 6 years, and 5.3% between 6 and 12 years. Repeat procedure was performed in 74% of patients. Reconnection in the PV antrum was found in 31% of patients after a single procedure and in no patients after 2 procedures. Non-PV triggers were found and targeted in all patients presenting with recurrent arrhythmia after ≥2 procedures. At 12 years, after multiple procedures, freedom from recurrent AF/atrial tachycardia was achieved in 87%.

Conclusions—

In patients with paroxysmal AF undergoing extended PV antrum isolation, the rate of late recurrence is lower than what previously reported with segmental or less extensive antral isolation. However, over more than a decade of follow-up, nearly 14% of patients developed recurrence because of new non-PV triggers.
Simultaneous His Bundle and Left Ventricular Pacing for Optimal Cardiac Resynchronization Therapy Delivery
Authors: Padeletti Luigi , Pieragnoli Paolo , Ricciardi Giuseppe , Innocenti Lisa , Checchi Luca , Padeletti Margherita , Michelucci Antonio , Picariello Francesco , Valsecchi Sergio
Published: May 2016

Background—

Previous studies have investigated the role of intrinsic conduction in optimizing cardiac resynchronization therapy. We investigated the role of fusing pacing-induced activation and intrinsic conduction in cardiac resynchronization therapy by evaluating the acute hemodynamic effects of simultaneous His-bundle (HIS) and left ventricular (LV) pacing.

Methods and Results—

We studied 11 patients with systolic heart failure and left bundle-branch block scheduled for cardiac resynchronization therapy implantation. On implantation, LV pressure–volume data were determined via conductance catheter. Standard leads were placed in the right atrium, at the right ventricular apex, and in a coronary vein. An additional electrode was temporarily positioned in the HIS. The following pacing configurations were systematically assessed: standard biventricular (right ventricular apex+LV), LV-only, HIS, simultaneous HIS and LV (HIS+LV). Each configuration was compared with the AAI mode at multiple atrioventricular delays (AVD). In comparison with the AAI, right ventricular apex+LV and LV-only pacing resulted in improved stroke volume (85±32 mL and 86±33 mL versus 58±23 mL;
P
<0.001), stroke work, maximum pressure derivative, and systolic dyssynchrony at individually optimized AVD. The optimal AVD was close to the P-H interval in the majority of patients. By contrast, HIS-LV pacing improved hemodynamic indexes at all AVD (stroke volume >76 mL at all fixed intervals and 88±31 mL at optimal interval; all
P
<0.001).

Conclusions—

Standard right ventricular apex+LV and LV-only pacing enhanced systolic function and LV synchrony at individually optimized AVD close to the measured intrinsic P-H interval. By contrast, HIS+LV pacing yielded improvements, regardless of AVD setting. These findings support the hypothesis of the crucial role of intrinsic right ventricular conduction in optimal cardiac resynchronization therapy delivery.
Morning and Evening Home Blood Pressure and Risks of Incident Stroke and Coronary Artery Disease in the Japanese General Practice Population
Authors: Hoshide Satoshi , Yano Yuichiro , Haimoto Hajime , Yamagiwa Kayo , Uchiba Kiyoshi , Nagasaka Shoichiro , Matsui Yoshio , Nakamura Akira , Fukutomi Motoki , Eguchi Kazuo , Ishikawa Joji , Kario Kazuomi
Published: May 2016

Our aim is to determine the optimal time schedule for home blood pressure (BP) monitoring that best predicts stroke and coronary artery disease in general practice. The Japan Morning Surge-Home Blood Pressure (J-HOP) study is a nationwide practice-based study that included 4310 Japanese with a history of or risk factors for cardiovascular disease, or both (mean age, 65 years; 79% used antihypertensive medication). Home BP measures were taken twice daily (morning and evening) over 14 days at baseline. During a mean follow-up of 4 years (16 929 person-years), 74 stroke and 77 coronary artery disease events occurred. Morning systolic BP (SBP) improved the discrimination of incident stroke (
C
statistics, 0.802; 95% confidence interval, 0.692–0.911) beyond traditional risk factors including office SBP (0.756; 0.646–0.866), whereas the changes were smaller with evening SBP (0.764; 0.653–0.874). The addition of evening SBP to the model (including traditional risk factors plus morning SBP) significantly reduced the discrimination of incident stroke (
C
statistics difference, −0.008; 95% confidence interval: −0.015 to −0.008;
P
=0.03). The category-free net reclassification improvement (0.3606; 95% confidence interval, 0.1317–0.5896), absolute integrated discrimination improvement (0.015; SE, 0.005), and relative integrated discrimination improvement (58.3%; all
P
<0.01) with the addition of morning SBP to the model (including traditional risk factors) were greater than those with evening SBP and with combined morning and evening SBP. Neither morning nor evening SBP improved coronary artery disease risk prediction. Morning home SBP itself should be evaluated to ensure best stroke prediction in clinical practice, at least in Japan. This should be confirmed in the different ethnic groups.

Clinical Trial Registration—

URL:
http://www.umin.ac.jp/ctr/
. Unique identifier: UMIN000000894.
Unsupervised Placental Gene Expression Profiling Identifies Clinically Relevant Subclasses of Human Preeclampsia
Authors: Leavey Katherine , Benton Samantha J. , Grynspan David , Kingdom John C. , Bainbridge Shannon A. , Cox Brian J.
Published: May 2016

Preeclampsia (PE) is a complex, hypertensive disorder of pregnancy, demonstrating considerable variability in maternal symptoms and fetal outcomes. Unfortunately, prior research has not accounted for this variability, resulting in a lack of robust biomarkers and effective treatments for PE. Here, we created a large (N=330) clinically relevant human placental microarray data set, consisting of 7 previously published studies and 157 highly annotated new samples from a single BioBank. Applying unsupervised clustering to this combined data set identified 3 clinically significant probable etiologies of PE: “maternal”, with healthy placentas and term deliveries; “canonical”, exhibiting expected clinical, ontological, and histopathologic features of PE; and “immunologic” with severe fetal growth restriction and evidence of maternal antifetal rejection. Moreover, these groups could be distinguished using a small quantitative polymerase chain reaction panel and demonstrated varying influence of maternal factors on PE development. An additional subclass of PE placentas was also revealed to form because of chromosomal abnormalities in these samples, supported by array-based comparative genomic hybridization analysis. Overall, our findings represent a new paradigm in our understanding of the origins and maternal–placental contributions to the pathology of PE. The study of PE represents a unique opportunity to access human tissue associated with a complex hypertensive disorder, and our novel approach could be applied to other hypertensive and heterogeneous human diseases.
Between Revolution and the Racial Ghetto
Authors: Johnson Cedric
Published: May 2016

This article revisits an historic exchange between two black ex-communists, Harold Cruse and Harry Haywood, a debate that prefigured many of the central contradictions of the black-power era. Their exchange followed Cruse’s influential 1962 essay forStudies on the Left, ‘Revolutionary Nationalism and the Afro-American’, which declared that the American Negro was a ‘subject of domestic colonialism’. Written against the prevailing liberal integrationist commitments of the civil-rights movement, his essay called for black economic and political independence, and inspired many of the younger activists who would give birth to the black-power movement. In a series of essays for the Bay Area black radical journalSoulbook, Haywood criticised Cruse’s mishandling of class politics among blacks, and his retreat from anti-capitalism. This forgotten episode is important on its own terms, for what it says about the character and limitations of left-political thinking during the sixties, and equally for understanding and contesting those commonsensical notions of African-American public life in our times which too often remain rooted in the vanished social context and political realities of the twentieth-century racial ghetto.
Marx after Minsky: Capital Surplus and the Current Crisis
Authors: Kincaid Jim
Published: May 2016

Minsky’s theory of financial instability helps clarify how Marxist theory can explain the highly financialised capitalism of today, and the crisis which started in 2008. The advanced economies currently have high realised profits in the productive sector and lagging rates of investment. Shareholder pressures encourage corporate strategies which focus on stock-market ratings and M&A operations, less on productive investment. Tax evasion and the build-up of reserve cash piles by corporations have contributed to a global surplus of what Marx calledloanable capital. This surplus has been augmented by the increasing inequality of personal wealth ownership and, in the international economy by, large current-account surpluses. The results include: huge profits for the financial system; low interest rates; recurrent boom and bust in asset markets; the fuelling of huge increases in household and government debt; and the combination of instability and stagnation which results from an excess supply of loanable capital.
New records of Cheilotheca (Ericaceae, Monotropoideae ) from China including the description of a new species
Authors: WU LEI , JIANG RI-HONG , YANG JIN-CAI , LIU YAN
Published: May 2016

The first record of Cheilotheca from China is reported here with the description of a new species, C. crocea, from evergreen broadleaved forest in south-central Guangxi of southern China. The new species is morphologically most similar to C. malayana, but it can be easily distinguished from the latter by its equal length filaments and elongate anthers with 2-longitudinal slits at dehiscence (vs. unequal length filaments and short anthers with a single terminal slit). The detailed morphological characters together with illustrations, diagnostic comparisons and habitat are presented.
Haplopacha (Lepidoptera: Lasiocampidae) reviewed: four new species, first descriptions of the genitalia of both sexes, and unique alar scale organs
Authors: DUPONT STEEN , SIMONSEN THOMAS J. , ZILLI ALBERTO
Published: May 2016

The collection of five specimens of Haplopacha at Ndumo Nature Reserve in South Africa highlights unknown species diversity in the monotypic genus. A total of four new species; H. riftensis sp. nov., H. tangani sp. nov., H. lunata sp. nov. and H. ndoumoi sp. nov., were identified in the Natural History Museum of London collection and the study of fresh specimens also revealed the presence of uniquely characteristic alar scale patches absent from the original species description of the genus type species H. cinerea. Based on the new species the descriptions of Haplopacha is amended. The identification of the new species was done using conventional light microscopy and scanning electron microscopy of the general morphology, wing venation and genitalia observations.
Description of a new genus, Galgoria gen. nov. (Hemiptera: Cicadidae: Cicadinae: Leptopsaltriini: Leptopsaltriina)
Authors: LEE YOUNG JUNE
Published: May 2016

A new cicada genus, Galgoria gen. nov., is described with Tanna herzbergi Schmidt, 1932 (from southern China) as its type species, which is placed in the subtribe Leptopsaltriina Moulton, 1923 of the tribe Leptopsaltriini Moulton, 1923 in the subfamily Cicadinae Latreille, 1802 (Hemiptera: Cicadidae). Tanna herzbergi Schmidt, 1932 is transferred from Tanna Distant, 1905 to Galgoria gen. nov. to become Galgoria herzbergi (Schmidt, 1932) comb. nov. Tanna apicalis Chen, 1940 syn. nov. and Tanna pseudocalis Lei & Chou, 1997 syn. nov. are synonymized here with Galgoria herzbergi (Schmidt, 1932) comb. nov.
Aerosol Impacts on Thermally Driven Orographic Convection
Authors: Nugent Alison D. , Watson Campbell D. , Thompson Gregory , Smith Ronald B.
Published: May 2016

Observations from the Dominica Experiment (DOMEX) field campaign clearly show aerosols having an impact on cloud microphysical properties in thermally driven orographic clouds. It is hypothesized that when convection is forced by island surface heating, aerosols from the mostly forested island surface are lofted into the clouds, resulting in the observed high concentration of aerosols and the high concentration of small cloud droplets. When trying to understand the impact of these surface-based aerosols on precipitation, however, observed differences in cloud-layer moisture add to the complexity. The WRF Model with the aerosol-aware Thompson microphysics scheme is used to study six idealized scenarios of thermally driven island convection: with and without a surface aerosol source, with a relatively dry cloud layer and with a moist cloud layer, and with no wind and with a weak background wind. It is found that at least a weak background wind is needed to ensure Dominica-relevant results and that the effect of cloud-layer moisture on cloud and precipitation formation dominates over the effect of aerosol. The aerosol impact is limited by the dominance of precipitation formation through accretion. Nevertheless, in order to match observed cloud microphysical properties and precipitation, both a relatively dry cloud layer and a surface aerosol source are needed. The impact of a surface aerosol source on precipitation is strongest when the environment is not conducive to cloud growth.
Connecting Climate Information Producers and Users: Boundary Organization, Knowledge Networks, and Information Brokers at Caribbean Climate Outlook Forums
Authors: Guido Zack , Rountree Valerie , Greene Christina , Gerlak Andrea , Trotman Adrian
Published: May 2016

Boundary organizations, knowledge networks, and information brokers have been suggested as mechanisms that help integrate information into decision-making and enhance interactions between the producers and users of climate information. While these mechanisms have been discussed in many studies in disparate fields of research, there has been little empirical research describing how they relate and support each other within studies on climate services. In this paper, two Caribbean Regional Climate Outlook Forums (CariCOFs) convened in 2014 are studied. CariCOFs facilitate the production of regional seasonal climate information and the dissemination of it to a diverse climate and socioeconomic region. Network analysis, key informant interviews, and small group discussions were used to answer two questions: 1) what are the barriers to using seasonal climate forecasts (SCFs) by CariCOF participants and 2) what are the iterative processes of information exchange that address these barriers? The barriers to using SCF include difficulty in demonstrating the value of the forecast to potential users, difficulty in interpreting and explaining the forecast to others, and challenges associated with the scientific language used in the information. To address these constraints, the convener of the CariCOF acts as a boundary organization by enabling interactions between participants representing diverse sectoral and geographic settings. This develops a network that helps build shared scientific understanding and knowledge about how different sectors experience climate risk. These interactions guide information brokering activities that help individuals communicate and translate climate information to facilitate understanding at local levels.
On the Justification of Antitrust
Authors: White Mark D.
Published: May 2016

Antitrust law exemplifies the fundamental contrast between economics, based on welfare and efficiency, and law, traditionally rooted in rights and justice, although the latter has been mostly ignored in the scholarly, legislative, and judicial history of antitrust. This paper adopts the perspective of property rights and corrective justice to explore the interrelated concepts of capitalism, antitrust, and democracy. After presenting the nature of capitalism and the role of the state as seen from each perspective, the paper examines antitrust law and policy through the lens of rights and justice, specifically asking which and whose rights are violated by the behavior forbidden by antitrust. Next, the paper responds to recent suggestions that antitrust can be understood as a valid response of a democratic government to the concerns of its citizens, which returns to the issues of the function of capitalism and the market with which the paper began.
Help-Seeking Attitudes of United Arab Emirates Students
Authors: Heath Patrick J. , Vogel David L. , Al-Darmaki Fatima R.
Published: May 2016

The psychological help-seeking patterns of college students in the United Arab Emirates (UAE) have only recently begun to be examined. Initial suggestions indicate that the majority of Emirati students treat help seeking from counselors as a last resort, which may be linked to aspects of Emirati culture including feared loss of societal face, stigma associated with seeking help, and discouragement of self-disclosure to individuals outside of the family. The relationship among fear of losing face, stigma, self-disclosure expectations (i.e., risks and benefits), and help-seeking attitudes was examined using structural equation modeling with 407 Emirati college students. Loss of face and stigma were related to self-disclosure expectations, which in turn were related to help-seeking attitudes. Gender differences were also examined with results indicating significant mean differences across all variables, as well as across two paths of the structural model. These findings are discussed within the cultural context of the UAE.
Counselors’ Current Counseling Practice
Authors: Wu Bo , Huang Xiting , Jackson Todd , Su Dan , Morrow Susan L.
Published: May 2016

The purpose of this qualitative study was to explore counselors’ efforts to implement a culturally responsive counseling practice in mainland China. Twenty-two counselors were interviewed about their perceptions of cultural discrepancies between Western-based counseling theories and approaches and the Chinese counseling context, as well as about the participants’ attempts to address these discrepancies in practice. Grounded theory was used as the method for data analysis, resulting in the identification of two main themes: Awareness of Cultural Discrepancies and Culture-Related Practice Strategies. For the latter theme, six subthemes were found: (a) relationship-oriented accommodation, (b) skill integration, (c) internal focus, (d) identifying commonalities, (e) employing accommodative approaches, and (f) theoretical integration. Implications for counselor education and practice in China, as well as further directions for research, are presented.
Belonging on Campus
Authors: Slaten Christopher D. , Elison Zachary M. , Lee Ji-Yeon , Yough Mike , Scalise Dominick
Published: May 2016

With the rise of Asian international students choosing to pursue higher education in the United States, research that identifies ways to promote Asian international students’ sense of belonging on campus is needed. We used consensual qualitative research methodology to examine factors that contribute to university belonging in a sample of Asian international students ( N = 11) from a large university in the Midwestern United States. Through data analysis, we identified 14 categories across five domains (i.e., Interpersonal Interactions, Experiences of Acculturation, Campus Environment, Emphasis on Academic Achievement, and Intrapersonal Factors) that contributed to university belonging. Our findings highlight the importance of within-group social connection, acculturative stress, and academic success on Asian international students’ sense of university belonging. We discuss differences between Asian international and domestic students’ sense of belonging as well as implications for counseling psychologists, including interventions at the individual and institutional levels.
Conditional Mediation Models of Intersecting Identities Among Female Asian International Students
Authors: Liu Tao , Wong Y. Joel , Tsai Pei-Chun
Published: May 2016

This study investigated how gender, racial, and nationality discrimination were related to the life satisfaction of female Asian international students directly and indirectly through loneliness, as well as how these pathways differed as a function of gender, racial, and nationality in-group solidarity. Participants were 216 female Asian international students from two public universities. Results demonstrated that all three types of discrimination predicted decreased life satisfaction. Loneliness mediated the relationship between perceived discrimination and life satisfaction. In addition, these mediation pathways differed as a function of in-group solidarity (e.g., sense of attachment to one’s racial group), providing evidence for conditional mediation effects. Gender solidarity was a protective factor that mitigated feelings of loneliness when experiencing gender discrimination, whereas racial and nationality solidarity were risk factors for decreased life satisfaction when experiencing loneliness. We provide research implications for international student scholars and clinical implications for university staff and clinicians.
Suicide in Greece 1992–2012: A time-series analysis
Authors: Papaslanis Theodoros , Kontaxakis Vassilis , Christodoulou Christos , Konstantakopoulos George , Kontaxaki Maria-Irini , Papadimitriou George N
Published: May 2016

Background and aims:

Since 2008, Greece has entered a long period of economic crisis with adverse effects on various aspects of daily life. In this frame, it is quite important to examine the suicide trends in Greece.

Method:

Our analysis covered the period 1992–2012. 2012 was the last year for which official suicide data were available. The inclusion of data for pre-crisis period enabled us to assess trends in suicide preceding the economic crisis, starting in 2008. Trends in sex- and age-adjusted standardized suicide rates (SSR) were analyzed using joinpoint regression.

Results:

Total SSR presented statistically significant annual decrease of 0.89% (95% confidence interval (CI): −1.7, −0.1) during the period 1992–2008. After 2009, the trend in total SSR increased statistically significant annual increase (12.48%; 95% CI: 0.3%, 26.1%). SSR in males presented an initial period of modest annual decrease (−0.84%; 95% CI: −1.6%, −0.1%), during the period 1992–2008. After 2009, an annual increase by 9.25% (95% CI: 2.7%, 16.3%) was revealed. No change in female SSR trend was observed during the studied period.

Conclusion:

According to the results of this study, there is clear evidence of an increase in the overall SSR and male SSR in Greece during the period of the current financial crisis.
PDL Progenitor–Mediated PDL Recovery Contributes to Orthodontic Relapse
Authors: Feng L. , Yang R. , Liu D. , Wang X. , Song Y. , Cao H. , He D. , Gan Y. , Kou X. , Zhou Y.
Published: May 2016

Periodontal ligament (PDL) is subjected to mechanical force during physiologic activities. PDL stem/progenitor cells are the main mesenchymal stem cells in PDL. However, how PDL progenitors participate in PDL homeostasis upon and after mechanical force is largely unknown. In this study, force-triggered orthodontic tooth movement and the following relapse were used as models to demonstrate the response of PDL progenitors and their role in PDL remodeling upon and after mechanical force. Upon orthodontic force, PDL collagen on the compression side significantly degraded, showing a broken and disorganized pattern. After force withdrawal, the degraded PDL collagen recovered during the early stage of relapse. Correspondingly, increased CD90+ PDL progenitors with suppressed expression of type I collagen (Col-I) were observed upon orthodontic force, whereas these cells accumulated at the degradation regions and regained Col-I expression after force withdrawal during early relapse. Our results further showed that compressive force altered cell morphology and repressed collagen expression in cultured PDL progenitors, which both recovered after force withdrawal. Force withdrawal–induced recovery of collagen expression in cultured PDL progenitors could be regulated by transforming growth factor–β (TGF-β), a key molecule for tissue homeostasis and extracellular matrix remodeling. More interesting, inhibiting the regained Col-I expression in CD90+ PDL progenitors by blocking TGF-β interrupted PDL collagen recovery and partially inhibited the early relapse. These data suggest that PDL progenitors can respond to mechanical force and may process intrinsic stability to recover to original status after force withdrawal. PDL progenitors with intrinsic stability are required for PDL recovery and consequently contribute to early orthodontic relapse, which can be regulated by TGF-β signaling.