bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of designed IS711 primers and universal primers of B4 and B5 for detection of Brucella spp. in clinical samples
Authors: Heidari Pedram , Salehi Mitra , Sepahi Abbas Akhavan , Razavi Mohamad Reza
Published: March 2020

Background: Brucellosis as a global concern is a zoonotic infectious disease which affects a large number of individuals in developing countries. Microbiological, serological and molecular approaches are useful for detection and identification of Brucella spp. A confirmed diagnosis requires isolation of Brucella from clinical specimens that is the most sensitive method in the acute and sub-acute phases of the diseases. On the other hand, molecular diagnostic techniques are more sensitive and more specific than serological techniques, especially in chronic localized cases because of antigenic cross-reactions or antibody titers lower than 160.
Until now different Brucella specific sequences like BCSP 31, IS711 and 16SrRNA have been amplified for detection of Brucella spp. In this study, the sensitivity and specificity of The B4-B5 primers and IS711 designed primers were evaluated for detection of of Brucella Spp. in the clinical samples.
Results : Amplification of extracted DNA from serum of 49 suspected patients were tested with two sets of specific primers. The BCSP31 amplicon was 223 bp and all the 49 (100%) serum specimens were positive by B4-B5 primers, including 4 cases with negative 2ME test result. The designed IS711 primers amplified the IS711 product with 448 bp length and 46 of 49 (93.87%) cases were positive. The sensitivity of the applied primers (B4-B5 and IS711) was evaluated by using the serial dilutions of extracted purified DNA molecules of B. melitensis and B. abortus . The B4-B5 primers can detect the least number of both B. melitensis and B. abortus , 0.1 CFU/reaction. However, the designed IS711 set is able to detect 10 CFU/reaction.
The B4-B5 primer and IS711 designed primer recognized 100% (49/49) and 94% (46/49) of the cases, respectively.
Conclusion: This study indicated that the sensitivity of B4-B5 primer is 100%, while the sensitivity of the designed primer of IS711 is 94%. The laboratory experiment revealed that designed IS711 set is 1×10 2 times more sensitive than sensitivity of the other experiments for detection of IS711 target sequence in the specimens.
Current situation of the presence of Dirofilaria immitis in dogs and humans in Bucaramanga, Colombia
Authors: Esteban-Mendoza M.Victoria , Arcila-Quiceno Víctor , Albarracín-Navas Javier Hernando , Hernández Isabel , Flechas-Alarcón María Camila , Morchón Rodrigo
Published: March 2020

Background: The cardiopulmonary dirofilariasis caused by Dirofilaria immitis, is a vector-born infection, which can be transmitted to humans. The main host are both domestic and wild canids. It mainly occurs in tropical and subtropical climates, temperature and humidity are the main factors that favor the presence and proliferation of Culicidae mosquitoes. There are few reports of this disease in dogs and humans in Colombia, a region with favorable climatic conditions for the development of this disease. Therefore, this research aimed to study its current prevalence in dogs and the risk of human exposure to the disease in Bucaramanga, one of the most populated areas in Colombia located at the center of the country. Furthermore, its demographic and environmental characteristics could be useful as a study model for other similar locations and neighboring countries.Method: Serum samples from 351 dogs and 506 humans from the Bucaramanga metropolitan area were analyzed. All dog samples were tested with a commercial immunochromatographic test kit to detect the presence of circulating antigens of D. immitis. Human samples were analyzed using a non-commercial ELISA test kit to detect IgG against the somatic antigens of adult D. immitis and Wolbachia. Positive results were further confirmed using a Western blot analysis.Results: Dirofilaria immitis prevalence was 10.82% (95% CI) in dogs and 5.12% (95% CI) in microfilaremic dogs. Seroprevalence in humans was 6.71% (95% CI) and was significantly higher in individuals aged 16–34 years and in women than in men.Conclusions:This study describes seropositivity to D. immitis for the first time in a Colombian human population located in the same area as that of dogs infected with D. immitis, which represents a potential threat to public health. In humans, age and sex can be considered risk factors for exposure to D. immitis.
Dissatisfaction between medical providers and patients in the Republic of Kazakhstan.
Authors: Zhumadilova Anara , Kozhakhmetova Aizhan , Kuanyshbayeva Gaukhar , Kazhen Madina , Akhmadiyeva Amina , Craig Brett J.
Published: March 2020

Background: Dissatisfaction among patients towards health care providers remains a serious concern in the Republic of Kazakhstan that requires further attention [1,2,3,4,5]. Patient-centered care, trust between patients and medical providers, the involvement of patients in their own treatment process, and effective communication are major areas in need of strengthening in order to improve outcomes of medical care [6-10]. The objective of this study was to broaden the investigation of patient dissatisfaction to various departments from different medical facilities in the city of Nur-Sultan and examine additional factors that may be influencing provider-patient communication and contributing to patient dissatisfaction. Methods: This cross-sectional study of 500 patients (response rate, 85.4%) and 500 health care providers (response rate, 86.4%) from one private and one state hospitals and two state policlinics in the city of Nur-Sultan, Kazakhstan, used questionnaires containing the Patient-Practitioner Orientation Scale (PPOS) and scales assessing life and job satisfaction, job effort-job reward balance, and patient evaluation of communication. Results: Our study showed that the majority of health care providers and even patients were doctor-centered as opposed to patient-centered in their expectations of the doctor visit. The patient-centered orientation of health care providers was negatively correlated with age (P=0.000218) and life satisfaction (P=0.000001). In patients, contrarily, patient-centeredness was enhanced by higher life satisfaction (P=0.040), although negatively correlated with age (P=2.659E-21). Conclusions: The results of this study demonstrate that younger health care providers and those with lower life satisfaction expect a more patient-centered approach to the doctor visit. Older respondents and those with higher life satisfaction, in contrast, reported doctor-centered attitudes. The majority of younger patients have a stronger belief in good health associated with patient centered care whereas the older population preferred a more doctor-centered approach to care. In all patients, the preference for patient-centered care was associated with higher satisfaction in life.
Development and Validation of Nomograms Predicting Overall and Cancer-specific Survival of Spinal and Pelvic Tumor Patients with Distant Metastasis
Authors: Zhang Hao , Tu Qihao , Zhou Chuanli , Wang Chao , Zhu Kai , Zhao Chong , Kong Meng , Hu Chuan , Zhang Ziyue , Ma Xuexiao
Published: March 2020

Background: Primary spinal bone tumors with distant metastasis are a sign of advanced stage and are usually accompanied by poor prognosis. This study is to identify the risk factors and establish prognostic nomograms to predict 1- and 3-year overall survival (OS) and cancer-specific survival (CSS) rates for spinal and pelvic bone tumor patients with distant metastasis.Patients and methods: Spinal and pelvic bone tumor patients with distant metastasis between 1998 and 2016 were selected for this study from the Surveillance, Epidemiology, and End Results (SEER) database. Nomograms to predict 1- and 3-year OS and CCS rates were constructed based on independent risk factors identified by univariate and multivariate Cox analyses. Concordance indexes (C-indexes), receiver operating characteristic (ROC) curves, calibration plots, and decision curve analysis (DCA) were used to assess the nomograms.Results: All patients (n=343) were randomly divided into a training cohort (n=243) and validation cohort (n=100). No significant differences were found in thedemographic data of all patients in the training and validation cohorts. Ultimately, only four independent risk factors (patient age, histology, grade and surgery) were identified as significantly associated with OS and CCS. The C-indices were 0.722 (95% CI, 0.685 to 0.759) and 0.686 (95% CI, 0.61 to 0.760) for the internal validation and external validation of the OS nomogram, respectively. Similarly, the C-indices based on the CCS nomogram were 0.717 (95% CI, 0.678 to 0.757) and 0.695 (95% CI, 0.619 to 0.771) for the internal validation and external validation, respectively. The calibration curves revealed that the predicted survival and actual survival were in concordance. DCA showed the clinical utility and benefits of the nomograms.Conclusion: The nomograms we constructed based on the SEER database can accurately predict individual patient survival.
Risk assessment of venous thromboembolism and bleeding in COVID-19 patients
Authors: Xu Jin-fu , Wang Lan , Zhao Lan , Li Feng , Liu Ji , Zhang Li , Li Qiuhong , Gu Jin , Liang Suo , Zhao Qinhua , Liu Jinmin
Published: March 2020

Background The coronavirus disease 2019 (COVID-19) is a newly recognized illness that has spread rapidly all over the world. Severe hypoxemic respiratory failure from COVID-19 will bring high risk of venous thromboembolism (VTE). Our study aims to identify in-hospital VTE risk and bleeding risk in COVID-19 patients. Methods We retrospectively studied 138 consecutively enrolled patients with COVID-19 and identified in-hospital VTE and bleeding risk by Padua Prediction Score and Improve bleed risk assessment model. The clinical data and features were analyzed in VTE patients. Results Our findings identified that 23 (16.67%) patients with COVID-19 were at high risk for VTE according to Padua prediction score, and 9(6.52%) patients were at high risk of bleeding for VTE prophylaxis according to Improve prediction score. Fifteen critically ill patients faced double high risk from thrombosis (Padua score more than 4 points in all 15[100%] patients) and hemorrhage (Improve score more than 7 points in 9[60.0%] patients). Thrombotic events were identified in four patients (2.9%) of all COVID-19 patients. All of them were diagnosed as deep vein thrombosis by ultrasound after 3 to 18 days after admission. Three (75.0%) were critically ill patients, which means the incidence of VTE among critically ill patients was 20%. One major hemorrhage was happened in critically ill patients during VTE treatment. Conclusion Critically ill patients with COVID-19 suffered both high risk of thrombosis and bleeding risks. More effective VTE prevention strategies based on an individual assessment of bleeding risks were necessary for critically ill patients with COVID-19.
Assessing the safety and feasibility of metastasis-directed radiation and neoadjuvant hormone and radiation therapy followed by radical prostatectomy for treating oligometastatic prostate cancer: protocol for an open-label, dose-escalation, single-centre phase I clinical trial
Authors: Zhao Xianzhi , Xiao Yu-Tian , Yang Yue , Ye Yusheng , Chang Yifan , Jiang Lingong , Eftekhar Md , Ren Shancheng , Zhang Huojun
Published: March 2020

Background The systemic therapy is currently recommended for patients with oligometastatic prostate cancer, however the prognosis has not been satisfactory. Therefore, it is necessary to explore more effective treatment to improve the prognosis. Oligometastatic prostate cancer is a special subgroup in patients with advanced cancer. The paragrim of treatment is shifting to a more aggressive approach. Stereotactic body radiotherapy (SBRT) is an emerging treatment alternative for patients with oligometastases with minimal toxic effects. What’s more, accumulating studies have proved safety as well as feasibility of radical prostatectomy and local or metastasis-directed radiotherapy for oligometastatic patients. The aim of this phase I prospective trial is to demonstrate the early evidence of safety and feasibility of metastasis-directed radiation and neoadjuvant hormone and radiation therapy followed by radical prostatectomy for treating oligometastatic prostate cancer Methods The patients with oligometastatic prostate cancer received 1 month of neoadjuvant androgen deprivation therapy (ADT) followed by metastasis-directed radition and abdominal or pelvic radiotherapy. Then offer radical prostatectomy at the interval of 4-8 weeks after radiotherapy and adjuvant ADT for 2 years. The primary endpoints of the study are safety as assessed by CTCAE 5.0 grading scale and intraoperative and postoperative day-30 morbidity. Secondary endpoints include the positive rate of post-operative edge, biochemical progression-free survival (bPFS), postoperative continence and sexual function recovery, quality of life (QoL), overall survival (OS) and adverse reactions of ADT. Discussion This is the first, phase I trial assessing the safety and feasibility of metastasis-directed radiation and neoadjuvant hormone and radiation therapy followed by radical prostatectomy treatment for patients with oligometastatic prostate cancer. If positive, the results of this trial may help to design subsequent phase II trials exploring the role of metastasis-directed radiation and neoadjuvant hormone and radiation therapy followed by radical prostatectomy in the randomized controlled study.
New Technical Solution for Hybrid Turbochargers
Authors: Rares Chiriac , Chiru Anghel
Published: March 2020

Internal combustion engines have an efficiency of operating which can be exploit to increase its performance. Part of the residual gases can be recovered through the technical solutions such as turbocharging. The turbocharging solution is one of the most popular technical solutions for increasing the energy performance of internal combustion engines. For the turbocharging process it is used a turbocharger. The turbocharger can contribute also with new technical solutions to increase the energy performance of the internal combustion engines. One of the solutions proposed for the theoretical and experimental research is the hybrid turbocharger, which has a double function, namely to compress the fresh air for the internal combustion engine, and to generate electric energy for the electric engine of the vehicle both for consumption other to be stored in batteries. This article aims is to present the result of the experimental research of the hybrid turbocharger, simulate and validate the new solutions for increasing the energy performance of internal combustion engines through hybrid turbochargers using a coupled electric generator. The simulations will be made using the AMESim Sofware developed by Siemens to demonstrate the efficiency of the new solutions such as a hybrid turbocharger through calculations. The tests will be carried out with the test bed CIMAT. CIMAT test bed is a machine which provides higt pressure air which simulate the combustion gases of an engine. The pourpose of the CIMAT test bed is to rotate the hybrid turbocharger turbine and also the compressor wheel. More technical information about the hybrid turbocharger test will be presented in the article and also constructive details. Based on the technical information and input data in the first phase it will be made an application for the simulation and validation of the prototype to demonstrate the great potential of the turbocharger to produce also green energy.
Information seeking behavior and associated factors among construction workers towards HIV/AIDS in Debre Berhan town, Northeast Ethiopia, 2019
Authors: TESSEMA MULUKEN
Published: March 2020

Background: Information seeking behavior is the purposive seeking for information as a consequence of a need to satisfy some goals. Information is crucial for preventing the spread of the virus as there is no cure or vaccination for HIV/AIDS. The aim of this study is to assess information seeking behavior and associated factors among construction workers towards HIV/AIDS in Debre Berhan town, Northwest Ethiopia.Methods: Institution based cross-sectional study was conducted. A total of 705 construction workers were included in the study. Multistage sampling technique was used to select the study participants. A structured pretested interview questionnaire was used for data collection. The data were entered and cleaned in EPI info and exported in to SPSS version 16 statistical package for analysis. Binary logistic regression was used to identify associated factors. A p-value of 0.05 was taken as a cut off value for statistical significant association. Results: Out of 705 workers, 200(28.4%) were categorized as having inappropriate information seeking behavior towards HIV/AIDS. Comprehensive knowledge of HIV/AIDS [AOR=2.26, 95% CI: 1.47-3.50], workers who received HIV information from work place [AOR=1.52, 95% CI:1.00-2.29] and tested for HIV [AOR=1.81, 95% CI:1.19-2.73] were more likely to have appropriate information seeking behavior towards HIV/AIDS whereas female construction workers [AOR=0.39, 95% CI: 0.27-0.56] were less likely to have appropriate information seeking behavior towards HIV/AIDS.Conclusion: Appropriate information seeking behavior towards HIV/AIDS among construction workers was not satisfactory. Comprehensive knowledge of HIV, information received from work place, being tested for HIV and workers sex (gender) affects information seeking behavior towards HIV/AIDS. Work place HIV prevention and control strategy need to be implemented to increase appropriate information seeking behavior towards HIV/AIDS.
Viscoelasticity measured by shear wave elastography in a rat model of NAFLD: comparison with dynamic mechanical analysis
Authors: Pi Zhaoke , Wang Mengke , Lin Haoming , Guo Yanrong , Chen Siping , Diao Xianfen , Xia Hui , Liu Guoqiang , Zeng Jie , Zhang Xinyu , Chen Xin
Published: March 2020

Background: Nonalcoholic fatty liver disease (NAFLD) is rapidly becoming one of the most common liver diseases. Ultrasound elastography has been used for the diagnosis of NAFLD. However, clinical research on steatosis by elastography technology has mainly focused on steatosis with fibrosis or non-alcoholic steatohepatitis (NASH), while steatosis without fibrosis has been poorly studied. Moreover, the relationship between liver viscoelasticity and steatosis grade is not clear. In this study, we evaluated the degree of liver steatosis in a simple steatosis rat model using shear wave elastography (SWE). Results: The viscoelasticity values of 69 rats with hepatic steatosis were measured quantitatively by SWE in vivo and validated by a dynamic mechanical analysis (DMA) test. Pathological sections were used to determine the steatosis grading for each rat. The results showed that the elasticity values obtained by the two methods followed the same trend, and the elasticity is significantly correlated with liver steatosis. The Pearson’s correlation coefficients indicate that elasticity obtained by SWE is positively linear correlated with DMA (r = 0.628, p = 7.85×10 -9 ) Conclusion: SWE might have the feasibility to be introduced as an auxiliary technique for NAFLD patients in clinical settings. However, the viscosity results measured by the two methods are significantly different because the two methods work in different frequency bands.
A RELAÇÃO DIALÉTICA ENTRE A INSERÇÃO NA CARREIRA E AS CONDIÇÕES DE TRABALHO DOCENTE
Authors: Cardoso Solange
Published: March 2020

Nos estudos sobre a formação e profissão docente, um dos aspectos que tem sido identificado como relevante refere-se à importância de se pensar a complexidade do início da carreira. As leituras e discussões realizadas sobre o início da docência, momento marcado por angústias, descobertas, desafios, medos, tentativas do tipo “erro e acerto” e, ainda um momento em que o professor vive um “choque de realidades” (Garcia, 1999; Huberman, 2000; Nóvoa, 1995, Papi e Martins, 2010; Lima, 2004 e 2006; Guarnieri, 2005; Mariano, 2006), permitiram que se aproximasse dos estudos sobre essa temática e despertou o interesse de melhor compreender essa etapa da carreira docente. Temos como objetivo neste trabalho apresentar nossas apreensões de um estudo bibliográfico que buscou compreender a relação dialética entre a inserção na carreira docente marcada por exigências pessoais, profissionais, organizacionais, contextuais, psicológicas, específicas e diferenciadas com as condições objetivas/materiais do trabalho. Os resultados deste trabalho apontaram que as características que envolvem a inserção na carreira docente, sejam elas no momento da descoberta, como o entusiasmo, ou no momento da sobrevivência, marcado pelas preocupações, angústias, medos e questionamentos nos ajudam a compreender as particularidades e os desafios que os professores estão vivenciando. E que se torna pertinente que a as condições do trabalho docente também sejam olhadas e relacionadas aos demais desafios que os professores vivenciam na etapa inicial da carreira, pois elas também colaboram para que o início da docência seja sofrido, questionado e em alguns casos culmina na desistência da profissão, tamanho o desafio que o professor tem que enfrentar. Além de se apresentarem como entraves para que o professor desenvolva um bom trabalho e contribuírem para ocasionar frustações e desânimos.
A SOCIALIZAÇÃO ENTRE PARES E AS EXPERIÊNCIAS PREGRESSAS: ELEMENTOS FACILITADORES PARA OS PROFESSORES INICIANTES DA EDUCAÇÃO INFANTIL
Authors: Cardoso Solange , Nunes Célia Fernandes
Published: March 2020

O crescimento quantitativo das pesquisas sobre formação de professores tem sido acompanhado também por um crescimento qualitativo, em que podemos observar a preocupação em abordar diferentes temas que procuram conhecer cada vez melhor os diversos aspectos que estão relacionados aos docentes, entre estes, o professor principiante. Autores como Marcelo Garcia (1999) e Lima (2004), têm apontado em seus estudos a importância da investigação de aspectos relativos à etapa de iniciação na carreira docente, haja vista que para eles essa é a etapa mais importante no desenvolvimento da carreira docente, mas também a mais complexa, marcada por momentos de tensão e dúvidas diante de uma fase cheia de novidades. Este estudo tem como objetivo apresentar alguns elementos facilitadores no início da carreira docente, a partir dos dados de um estudo concluído no Programa de Pós Graduação em Educação na Universidade Federal de Ouro Preto, sobre os desafios da docência das professoras iniciantes da Educação Infantil da Região dos Inconfidentes, cujo problema investigado refere-se ao modo como os professores principiantes vivenciam os desafios do início da docência. Como referencial metodológico, desenvolvemos uma pesquisa de abordagem predominantemente qualitativa. Para a coleta de dados optamos por utilizar o questionário, a observação e a entrevista semiestruturada a um grupo de professoras selecionado a partir de critérios previamente definidos, qual seja, ser professor iniciante com até 5 anos de carreira na Educação Infantil. Os dados da pesquisa apontaram que a socialização dos professores iniciantes, as experiências pregressas com a sala de aula e os estágios foram apresentados como fatores facilitadores no início da carreira docente. E apontaram que essa rede de relações no cotidiano onde a socialização ocorre com diversos sujeitos da escola e fora dela, favorece para que os professores aprendam sobre o trabalho docência de forma menos sofrida.
Qaly - ocena efektywności klinicznej z użyciem kwestionariusza EQ-5D-3L
Authors: Pietrzak Agata Karolina , Kucnerowicz Karolina , Cholewiński Witold , Martenka Piotr , Strzesak Erwin
Published: March 2020

Jakość życia chorych (ang. quality of life; QoL, QOL), jest jednym z najważniejszych zagadnień, poruszanych w onkologii. Szczególnie istotnym elementem, rzutującym na QoL, jest samoocena chorego w odniesieniu do stanu zdrowia (ang. health-related QoL, HRQoL), co przekłada się na możliwość samodzielnego życia na różnych etapach choroby. Ocena HRQoL opiera się na kalkulacji współczynnika Qaly, który stanowi sumę punktów, przyporządkowanych poszczególnym aspektom samooceny chorego. Ponieważ wartości wskaźnika Qaly odpowiada ustalona kwota, współczynnik wykorzystywany jest do szacowania całkowitego zysku postępowania medycznego w kontekście planowania wydatków w sektorze ochrony zdrowia.
Factors associated with adherence to safe water chain practices among refugees in Pagirinya refugee settlement, Northern Uganda
Authors: Mugumya Thomas , Isunju John Bosco , Ssekamatte Tonny , Wafula Solomon Tsebeni , Mugambe Richard K.
Published: March 2020

Poor adherence to safe water chain practices is a major obstacle to consumption of safe drinking water. In refugee settings, adherence to safe water chain is critical in minimizing water-related diseases. Despite this, little is known about the level of adherence to safe water chain and associated factors, especially in emergency settings. In this study, we interviewed 400 household heads in Pagrinya refugee camp in Northern Uganda and assessed household level adherence to safe water chain practice and associated factors. Modified Poisson regression was used to model the association between adherence to safe water chain and independent variables. All households utilized improved water sources and 74.0% had high adherence to safe water chain. Having post-primary education and high level of knowledge about the safe water chain were positive predictors of high adherence to the safe water chain while round travel time exceeding 1 hour during water collection was negatively associated with high adherence. There is a need for awareness campaigns on safe water chain maintenance among refugees without any formal education. Constructing more water sources would also minimize round travel time during water collection and enable households to collect sufficient water that enables hygienic water storage and use.
Incentivo ao desenvolvimento das ações do sistema de vigilância alimentar e nutricional para os agentes comunitários de saúde
Authors: Dardengo Marina Junger Delôgo , Da Silva Carlos Eduardo Dilen , Maciel Paulete Maria Ambrósio
Published: March 2020

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O direito de inclusão dos professores da educação infantil para vacinação contra A H1N1
Authors: Mendes Kellen Nascimento , Almeida Márcia Valéria de Souza , Angeli Jhuli Keli
Published: March 2020

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Capacitação permanente em boas práticas de manipulação de alimento para vendedores ambulantes
Authors: Gomes Carlos Hemilio Fontana , Lazarini Welington Serra , Madureira Renata
Published: March 2020

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Análise da conformidade das prescrições medicamentosas dos setores públicos e privados
Authors: Silva Diêgo Padua , Portugal Flávia Batista , Gutian Júnior Geraldo Mendes
Published: March 2020

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Avaliação do verniz fluoretado na redução de S. mutans
Authors: Medeiros U. V. , Carneiro F. C.
Published: March 2020

Verniz fluoretado; Cárie dental; S. mutans.
Aborto: atenção humanizada e aspectos legais
Authors: Lins-Kusterer Liliane , Lins Matheus , Vasconcelos Camila
Published: March 2020

Introdução: O abortamento é definido como a interrupção gestacional até a 20ª/22ª semana e com o concepto pesando menos que 500g. Objetivo: Trata-se de estudo teórico em que se pretendeu analisar o abortamento e suas práticas lícitas e ilícitas sob a ótica do Princípio Fundamental da Dignidade Humana, em sua perspectiva constitucional, tendo em vista, ainda, suas considerações éticas, normativas penais e deontológicas, estas últimas conforme a codificação profissional da medicina no Brasil. Métodos: Para contextualização da problemática, partiu-se da apresentação de dados colhidos em estudos estatísticos prévios, trabalhando-se, em seguida, com a análise teórica dos impactos negativos da criminalização do aborto no Brasil diante de problemas de ordem socioeconômica verificados. Resultados: Os aspectos religiosos e a liberdade fundamental também restaram elencados nos argumentos refletidos no texto, apresentando vieses de argumentos favoráveis e contrários à realização do ato, incluindo-se o instituto da objeção de consciência e seus possíveis limites. Conclusão: Alcança-se, por fim, a ratificação do devido respeito à dignidade humana reforçando-se a manutenção do respeito ao direito à saúde independentemente à natureza do ato enquanto conforme ou não ao quanto disposto pela norma brasileira, na atualidade.
Análise das tensões intrínsecas ao dispositivo de Procriação Medicamente Assistida com doação de gametas sob o olhar da Sociologia Pragmática
Authors: Delaunay Catarina
Published: March 2020

Introdução: A procriação medicamente assistida (PMA) com recurso à doação de gâmetas não suscita somente debates científicos, morais, políticos, sociais e religiosos, mas abrange também os envolvimentos pessoais nas relações mais próximas. Objetivo: Analisar as controvérsias, tensões e constrangimentos, visíveis ou invisíveis, em torno da PMA com dadores terceiros em França e em Portugal. Métodos: Para este projeto, foram realizadas 66 entrevistas a um conjunto diferenciado de atores diretamente ligados às técnicas de PMA, seja porque a elas recorrem (casais heterossexuais e homossexuais) seja porque são responsáveis pela sua implementação (especialistas em medicina reprodutiva e embriologia) ou pela sua discussão e regulamentação (deputados/senadores e membros de comissões de ética). No total, entrevistámos 20 beneficiários (dez em França e dez em Portugal) e 46 profissionais (22 em França e 24 em Portugal). Resultados: As dez mulheres entrevistadas, nos dois países considerados, apresentam uma semelhança de trajetórias biográficas e de cuidados, numa sucessão de provações no que respeita às suas vivências da infertilidade. Encontram-se todas em situação de conjugalidade heterossexual, têm idades compreendidas entre os 34 e os 43 anos, trabalham no sector terciário e possuem formação superior, exceto em dois casos (ensino secundário completo). Além disso, foi possível explorar as tensões – mas igualmente os compromissos – que emergem no seio de casais com problemas de infertilidade que optam por recorrer à PMA com dadores terceiros. Conclusão: É certamente possível padronizar e regular o procedimento de PMA com dadores terceiros. No entanto, mesmo que os casais se encontrem num processo voluntário e manifesto de anonimização do procedimento, essa tensão permanece, porque é constitutiva do objeto.
O padrão da atividade física de brasileiros com osteoporose
Authors: De Lima Dartel Ferrari , Michael Pereira da Silva  , Oldemar Mazzardo Júnior  , Adelar Aparecido Sampaio  , Maria das Graças Anguera  , Lohran Anguera Lima  , Olinda do Carmo Luiz
Published: March 2020

Introdução: A osteogênese pode ser estimulada pela ação resultante de práticas diferenciadas de atividade física. Objetivo: Descreveu o padrão da atividade física (AF) no lazer e no deslocamento ativo de brasileiros adultos com osteoporose. Método: Dados transversais foram obtidos do Sistema de Vigilância de Fatores de Risco e Proteção para Doenças Crônicas não Transmissíveis de 2008, envolvendo 52.614 adultos com 18 anos ou mais de idade, residentes nas capitais brasileiras e no Distrito Federal e entrevistados por inquérito telefônico. Resultados: As mulheres portadoras de osteoporose foram significativamente mais inativas (64,3%; IC95%: 62,8 – 66,9) do que os homens (53,8%; IC95%: 50,6 – 56,4). No conjunto da amostra, (24,8%; IC95%: 21,4 – 28,1) realizaram AF em quantidade suficiente para a promoção da saúde geral. A caminhada foi o principal exercício relatado (67,8%: IC95%; 61,7 – 73,2), seguido da hidroginástica (8,9%; IC95%: 5,6 – 13,2) e musculação (6,5%: IC95%; 2,6 – 9,1). Somente 5,7% (IC95% 0,5 – 11,3) e 0,8% (IC95%: 0,3 – 2,0) dos homens e mulheres mais ativos, respectivamente, relataram baixa frequência semanal das atividades (1 a 2 dias). Entre os menos ativos, a baixa frequência semanal foi mais prevalente, alcançando 55,0% (IC95%: 26,0 – 84,1) e 76,9% (IC95%: 67,7 –86,0) para homens e mulheres, respectivamente. Cerca de 90% dos entrevistados relataram atividades com duração diária de 30 minutos ou mais. Conclusão: A inatividade física foi comum para aproximadamente 50% dos adultos com osteoporose. Outros 25% alcançaram a meta mínima recomendada, mediante a prática de exercícios de baixo impacto.
Traumatismo dentário com fratura radicular: relato de caso clínico
Authors: Penina Patrícia , Passos Joziana Becevelli , Miotto Maria Helena Monteiro de Barros
Published: March 2020

Fraturas radículares; Trauma dental.
Controle dos ecossistemas microbianos bucais com a utilização de dentifrícios
Authors: Medeiros Urubatan Vieira de , Velmovitsky Lenise , Mota Luise , Morais Andréa Pereira de
Published: March 2020

Prevenção; Dentifrício; Placa bacteriana.
Responsabilidade profissional do cirurgião-dentista, mediante o arquivamento da documentação odontológica
Authors: Emmerich Adauto , Barbosa Andrpe , Bermond Carla G.
Published: March 2020

Documentação odontológica; Responsabilidade profissional.
O periodonto e as restaurações indiretas: parte II - procedimentos clínicos associados
Authors: Mendonça Juliano Sartori , Santiago Sérgio Lima , Pereira Lúcia Coelho Garcia , Pereira Marcelo Agnoletti , Francischone Carlos Eduardo , Pereira José Carlos
Published: March 2020

Gengiva; Periodonto; Periodontia; Preparo da cavidade dentária.
Limas endodônticas manuais de aço inoxidável e de níquel-titânio: ensaio de torção até a fratura
Authors: Lopes Hélio Pereira , Elias Carlos Nelson , Siqueira Jr José Freitas , Araújo Filho Wantuil Rodrigues
Published: March 2020

Fratura por torção; Limas endodônticas de aço inoxidável e de NiTi; Limas endodônticas torcidas e usinadas.
O cirurgião-dentista inserido no contexto social como promotor de saúde bucal
Authors: Tavares Mara José , Vianna Roberto , Tura Luiz Fernando Rangel
Published: March 2020

Promoção de saúde bucal; Prevenção; Educação em odontologia.
Lábio duplo: relato de caso
Authors: Prata Daniela Siqueira Machado , Ambrizzi Darlo Ravazzi , Pereira Filho Valfrido Antônio , Vieira Eduardo Hochuli , Gabrielli Mario Francisco Real , Gabrielli Marisa Aparecida Cabrini
Published: March 2020

Lábio; Patologia bucal; Glândulas salivares menores; Hipertrofia.
Perfil de médicos pediatras do Estado do Espírito Santo diante da saúde bucal
Authors: Pandolfi Margareth , Maeda Fernanda Hirome , Torres Luciene Pereira , Gomes Maria José
Published: March 2020

Saúde bucal; Odontologia preventiva; Pediatras.
Editorial
Authors: Miotto Maria Helena Monteiro de Barros , De Barros Liliana A. Pimenta
Published: March 2020

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Revisões sistemáticas da literatura
Authors: Loureiro Carlos Alfredo , Baêta Guimarães Maria Aparecida M. , Araújo Vânia Eloísa de
Published: March 2020

Odontologia baseada em evidência; Revisão sistemática; Metanálise.
A importância dos bifosfonatos na movimentação dentária induzida: uma revisão de literatura
Authors: Bortolotti Ricardo , Barros Márcia Gabriella Lino de , Ribeiro Francisco Carlos
Published: March 2020

Movimentação dentária; Doenças ósseas; Osteoporose; Menopausa.
Fatores que influenciam a utilização dos serviços odontológicos
Authors: Barcellos Ludmilla A. , Miotto Maria Helena Monteiro de Barros
Published: March 2020

Utilização; Serviços odontológicos; Adultos.
Estudos sobre a participação de bactérias anaeróbicas em canais radiculares humanos
Authors: Gouvêa Cristiane Leite , Feitosa Alfredo Carlos R. , Ganhoto Maria Rebeca A. , Roldi Armelindo
Published: March 2020

Bactérias anaeróbicas; Canais Radiculares.
Estomatite aftosa recorrente: uma revisão sobre as diferentes hipóteses de sua etiopatogenia
Authors: Balassiano Karen Zavaro , Penna Franca Maria Eduarda , Lourenço Simone de Queiroz Chaves
Published: March 2020

Estomatite aftosa recorrente; Etiopatogenia; Aftas.
Estudo da anatomia do sistema de canais radiculares de caninos superiores humanos, utilizando cortes macroscópicos e a técnica da diafanização
Authors: Azeredo Rogério Albuquerque , Bautz Wilian Grassi , Scárdua Eduardo Filipe da Paz , Lorenzoni Diego Coelho , Oliveira Priscila Souza , Peyneau Priscila Dias , Buaiz Mariana Lordelo , Provetti Junior José Valter , Maia Ana Laurita Nunes , Rocha Cristiano Gonçalves da
Published: March 2020

Canino superior; Canal radicular; Diafanização.
Doença periodontal como fator de risco para doenças sistêmicas: parte II - diabetes mellitus, doença respiratória, nascimento de bebê prematuro e de baixo peso e outras doenças
Authors: Zanotti Lenize , Medeiros Urubatan , Aguiar Renata
Published: March 2020

Diabetes mellitus; Doença Periodontal; Doença respiratória; Nascimento de bebê prematuro e de baixo peso.
O uso do selante sobre fossas e fissuras com lesões de cárie: uma revisão
Authors: Faria Gisele , Nelson Filho Paulo , Silva Léa Assed Bezerra da , Ito Izabel Yoko
Published: March 2020

Selante de fossas e fissuras; Cárie.
Distração osteogênica na região anterior da mandíbula: relato de caso clínico
Authors: Bourguignon Filho Aguimar de Matos , Dias Eduardo Cláudio Lopes de Chames Mello , Chiarelli Fábio Matos , Da Rós Lorena
Published: March 2020

Distração osteogênica; Perda óssea; Rebordo alveolar.
Análise comparativa (in vitro) da extrusão apical de debris por meio de três técnicas de instrumentação: step down, profile e k3
Authors: Diblasi Flávio , Vilhena Fernando Sili , Sassone Luciana Moura , Fidel Sandra Rivera , Fidel Rivali Antonio Sergio
Published: March 2020

Extrusão apical; Técnicas de instrumentação.
Avaliação clínica de materiais odontológicos empregados como selantes oclusais após seis e doze meses
Authors: Gomes Maria José , Gianordoli Neto Ranulfo
Published: March 2020

Selante de fissuras; Cárie dentária.
Editorial
Authors: Gomes Maria José , Miotto Maria Helena Monteiro de Barros
Published: March 2020

.
Pênfigo vulgar: relato de caso clínico
Authors: Miyahara Glauco Issamu , Callestini Renata , Lawall Melaine de Almeida
Published: March 2020

Pênfigo vulgar; Diagnóstico; Tratamento.
Susceptibilidade a antimicrobianos de bactérias pigmentadas de negro isoladas de tecidos periimplantares sadios
Authors: Pfau Eduardo Augusto , Avila-Campos Mario Julio
Published: March 2020

Bactérias anaeróbicas; Periimplante; Porphyromonas; Prevoteela.
Desigualdade social e prevalência da cárie em um pequeno município rural do sul do Brasil
Authors: Michel-Crosato Edgard , Saliba Orlando , Biazevic Maria Gabriel Haye , Saliba Nemre Adas , Crosato Edgard
Published: March 2020

Epidemiologia; Saúde bucal; Iniquidades.
Avaliação da padronização dos instrumentos endodônticos
Authors: Freitas Lilia Maria Anderson Costa de , Lopes Hélio Pereira , Pereira Rosana de Souza , Roldi Armelindo , Ribeiro Francisco Carlos , Freitas Jair Carlos Checon de
Published: March 2020

Instrumentos endodônticos; Padronização; Avaliação microscópica.
A Novel Hybrid Filter/Wrapper Feature Selection Approach Based on Improved Fruit Fly Optimization Algorithm and Chi-square Test for High Dimensional Microarray Data
Authors: Yan Chaokun , Wu Bin , Ma Jingjing , Zhang Ge , Luo Junwei , Wang Jianlin , Luo Huimin
Published: March 2020

Background:

Microarray data is widely utilized for disease analysis and diagnosis.
However, it is hard to process them directly and achieve high classification accuracy due to the
intrinsic characteristics of high dimensionality and small size samples. As an important data
preprocessing technique, feature selection is usually used to reduce the dimensionality of some
datasets.

Methods:

Given the limitations of employing filter or wrapper approaches individually for feature
selection, in the study, a novel hybrid filter-wrapper approach, CS_IFOA, is proposed for high
dimensional datasets. First, the Chi-square Test is utilized to filter out some irrelevant or redundant
features. Next, an improved binary Fruit Fly Optimization algorithm is conducted to further search
the optimal feature subset without degrading the classification accuracy. Here, the KNN classifier
with the 10-fold-CV is utilized to evaluate the classification accuracy.

Results:

Extensive experimental results on six benchmark biomedical datasets show that the
proposed CS-IFOA can achieve superior performance compared with other state-of-the-art
methods. The CS-IFOA can get a smaller number of features while achieving higher classification
accuracy. Furthermore, the standard deviation of the experimental results is relatively small, which
indicates that the proposed algorithm is relatively robust.

Conclusion:

The results confirmed the efficiency of our approach in identifying some important
genes for high-dimensional biomedical datasets, which can be used as an ideal pre-processing tool
to help optimize the feature selection process, and improve the efficiency of disease diagnosis.
Fast Dissolving/Disintegrating Dosage Forms of Natural Active Compounds and Alternative Medicines
Authors: Singh Anupama , Kharb Vandana , Saharan Vikas Anand
Published: March 2020

Fast Dissolving/Disintegrating Dosage Forms (FDDFs) are a group of dosage forms which
dissolve or disintegrate quickly, leading to fast distribution of active ingredients at the site of administration;
thereby providing ease of oral ingestion of solid unit dosage forms and have the potential to
enhance transmucosal absorption. With time, the use of FDDFs in alternative systems has significantly
increased. Homeopathic systems and traditional Chinese medicine have embraced FDDFs for the delivery
of active compounds. Most of the patents in this area are from China or by the Chinese innovators.
In Europe and US, FDDFs have been extensively studied for the delivery of natural active compounds.
It was fascinating to know that some new dosage forms and new routes of delivering active
compounds are also making their way to the family of FDDFs. The dose of active compound, size of
dosage forms, standardization of extracts, polyherbal mixtures, stability of active compounds, safety,
efficacy and pharmacokinetics are challenging issues for developing FDDF herbal formulations or
phytopharmaceuticals.
Design and Development of 4-Bit Gray Code Counter Circuit Using Reversible Logic Gate
Authors: Maity Heranmoy , Sen Barnali , Verma Ishika , Biswas Arindam , Pal Anita , Bhattacharjee Anup K.
Published: March 2020

Aim:

This paper proposed the design and development of 4-Bit Gray Code Counter Circuit
Using Reversible Logic Gate.

Methods:

The 4-Bit Gray Code Counter Circuit can be design using SAM gate, Feynman gate (FG),
double Feynman gate (DFG) and NOT gate. The proposed circuit is the combined application of 4-bit
binary asynchronous counter and 4-bit binary to gray code converter circuit.

Results:

The proposed gray code counter is designed using four no. of SAM gate, three no. of DFG,
one FG and seven reversible NOT gate. The QC, GO and CI of proposed circuit are correspondingly
30, 4 and 7.

Conclusion:

The novel reversible gray code counter have been designed using existing reversible logic
gate. The proposed gray code counter is designed using four no. of SAM gate, three no. of DFG, one FG
and seven reversible NOT gate. The QC, GO and CI of proposed circuit are correspondingly 30, 4 and 7.
A New Ecological HPLC Method for Determination of Vancomycin Dosage form
Authors: Aleixa do Nascimento Patrícia , Kogawa Ana Carolina , Salgado Hérida R.N.
Published: March 2020

Aims:

To develop and validate a new ecological HPLC method for the determination of
vancomycin dosage form.

Background:

Vancomycin is an important antimicrobial. According to the literature, there are
many methods that use HPLC, but none of these methods follow the green analytical chemistry
principles.

Objective:

Therefore, a green analytical method to quantify vancomycin in lyophilized powder for
injectable solution by HPLC was developed.

Materials and Methods:

It uses less quantity of toxic solvents, minimizing the costs and optimizing
the time of analysis. Water + 0.1% acetic acid and ethanol (85:15, v/v), 0.5 mL min-1, and C18
column (15 cm) at 280 nm were used.

Results and Discussion:

The method was linear in the range of 40 to 140 μg mL-1, with a correlation
coefficient of 0.9998. It was selective when subjected to acid 0.1M, basic 0.01M, oxidative
0.3%, UV light and neutral degradation in a bath of 60 ºC for 8 hours. The precision of the method
was proved at intraday (RSD 1.08%), interday (RSD 0.47%) and intermediate levels (RSD
2.35%). It was accurate with a mean recovery of 100.19% and robust when changes were performed
in seven parameters of the method and analyzed by the Youden and Steiner test.

Conclusion:

The method can be applied to routine quality control of vancomycin lyophilized
powder for injectable solution as an ecological and sustainable alternative that contemplates the
green analytical chemistry and the current pharmaceutical analyses.
Stackelberg Game Analysis of Enterprise Operation Improvement Decision and Consumer Choice Behaviour
Authors: Zhang Gongliang , Sun Qian
Published: March 2020

:

To explore the effective improvement of business decision-making, this paper takes consumers
as a utility factor in business decision-making. Under the assumption of maximizing the interests
of consumers and manager, it describes the problems and establishes Stackelberg game model,
which uses the heuristic algorithm of sensitivity to solve the business decision-making model of
two charging items with the number of consumers as N through calculation, and discussed the corresponding
strategies, hopes can provide decision-making reference for the managing of two charging
projects at the same time. The results show that for the operation with two charging items, the manager
shall decide whether to improve and the order of improvement according to the improvement
cost and the net utility after improvement.
De spiritualiteit van O. Noordmans
Authors: Wassenaar J.D.Th.
Published: March 2020

Recent discussions of “a contemplative turn in theology” disclose greater preference for a turn away from an abstract, cognitive, intellectual way of speaking. Dr. O. Noordmans (1871­1956) demonstrated such a turn much earlier with a theology rooted in the “womb of piety” as experienced in his parental home. Reformed theology is characterized by earnestness and simplicity, not rooted in a school; it has a strong eschatological focus. Critical response charged Noordmans’ theology with spiritualism and world­avoidance. Against this critique, this essay argues that this spiritualism is best understood as a historical spiritualism, in which the concrete reality of church and world is always present.
The Use of Social Media in Millennials’ Teaching and Learning Activities in Design-Related Course
Authors: Abdul Kadir Syazwani
Published: March 2020

This paper discusses an action research on the use of social media in millennials’ teaching and learning activities in a design-related course. The objective is to investigate students’ feedback on their experience of utilizing social media as a platform to submit and present an assignment. The method employed is a questionnaire survey on students’ experience of utilizing such method in their study. Many respondents also provided additional comments regarding this unconventional approach. The findings of this study show that most respondents favor the use of social networking apps in their learning activities, especially for courses related to design and creativity.Keywords: Social media; Millennials; Teaching and learning; Action researcheISSN: 2398-4287 © 2020. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.DOI: https://doi.org/10.21834/e-bpj.v5i13.2087