bluuebunny/crossref_metadata_2025 huggingface dataset:
Tendência temporal e distribuição espacial das sífilis gestacional e congênita no Estado do Espírito Santo entre 2010 a 2019
Authors: Veloso Francielle Bosi Rodrigues , Cruz Stefanie Lievore , Carvalho Arthur , Braga Fábio Ribeiro
Published: August 2022

Objetivo: Avaliar a tendência temporal e a distribuição espacial da sífilis gestacional e congênita no Estado do Espírito Santo de 2010 a 2019. Materiais e métodos: Trata-se de um estudo ecológico de série temporal com dados sobre sífilis gestacional e congênita obtidos do Sistema Nacional de Agravos e Notificações (SINAN) e de nascidos vivos no Sistema de Informação sobre os Nascidos Vivos (SINASC). Foram calculadas taxas de incidência de sífilis gestacional e congênita, que foram agrupadas conforme as macrorregiões de saúde do IBGE e analisadas em biênios. Resultados: Foram notificados 9.763 casos de sífilis gestacional e 3.912 casos de sífilis congênita. As taxas de sífilis gestacional variaram de 1,46 em 2013 a 31,49 casos por 1.000 nascidos vivos em 2018, as taxas de sífilis congênita, por sua vez, variaram de 0,12 em 2010 a 11,51 casos por 1.000 nascidos vivos em 2017. Quanto às macrorregiões, a região Sul apresentou as menores taxas de incidência (2,32 casos/1.000 nascidos vivos para sífilis gestacional e 0,54/1.000 nascidos vivos para sífilis congênita) e a região Metropolitana as maiores (37,08 casos/1.000 nascidos vivos para sífilis gestacional e 13,74/1.000 nascidos vivos para sífilis congênita). Conclusão: O aumento dos casos da doença sugere deficiência na qualidade do pré-natal.
EXERCÍCIO PROFISSIONAL DE DOCENTES COM DEFICIÊNCIA VISUAL: TENSIONANDO A ACESSIBILIDADE
Authors: Oliveira Milene da Silva , Pieczkowski Tania Mara Zancanaro
Published: August 2022

Em uma sociedade que se constitui por olhares padronizados e pela lógica da normalidade, os docentes com deficiência visual se distanciam dos padrões de corpo, comportamento, jeitos de ser e fazer a docência, o que causa estranhamentos. Este artigo resulta de uma pesquisa que objetivou compreender como docentes com deficiência visual (cegos/as ou com baixa visão) enfrentam os desafios de exercer a profissão, respondendo ao seguinte problema de pesquisa: de que forma professores/as com deficiência visual narram a acessibilidade para o exercício da profissão? Para isso, realizaram-se entrevistas narrativas com sete docentes com deficiência visual, atuantes na Educação Básica nos três estados da Região Sul do Brasil. As narrativas foram organizadas em agrupamentos temáticos e examinadas a partir da perspectiva da análise do discurso, amparada pelos referenciais foucaultianos. O estudo aponta que, quanto maiores forem as barreiras sociais impostas, menores serão as possibilidades de inclusão de docentes com deficiência visual no exercício profissional. Revela também, que a inclusão e acessibilidade tem sido pensadas mais para os estudantes com deficiência e menos para os professores, cuja inserção profissional é recente e ainda causa estranhamento nos espaços escolares.
LOS ESTUDIANTES QUE SOBRAN: MOTIVACIONES Y CAUSAS DEL FRACASO ESCOLAR EN JÓVENES ESTUDIANTES CHILENOS
Authors: Burgos Cristian Andrés Padilla
Published: August 2022

Las discusiones actuales sobre fracaso escolar han hecho hincapié en tres dimensiones íntimamente relacionadas, a saber: el individuo, el contexto escolar y el contexto familiar/comunitario. A su vez, han señalado la importancia de los contextos de vulnerabilidad para su estudio, especialmente en países como Chile, donde la educación ha vivido transformaciones estructurales que en las últimas décadas han agudizado problemas como la segregación y el deterioro de la calidad de la educación pública ofrecida para estos sectores. En tal sentido, el presente artículo busca conocer los discursos que un grupo de jóvenes expresan respecto a sus experiencias de fracaso escolar en la ciudad de Temuco, Chile. El estudio fue de tipo exploratorio y de carácter cualitativo a través de un estudio de caso, y contó con los discursos de once jóvenes, siete profesionales del Servicio Nacional de Menores de Chile y cuatro profesionales de la educación. Los resultados muestran que los discursos de los jóvenes hacen referencia explícita a las 3 dimensiones antes mencionadas. Se destacan los conceptos de desmotivación y estudiantes problemáticos, en la dimensión individual; cultura escolar y exclusión de la diferencia, en la dimensión escolar; y transgeneracionalidad, grupo de pares y barrios vulnerables, en la dimensión familiar/comunitaria.
THE HISTORY OF THE ECUADORIAN CORPORATION AND ITS CONTRIBUTION TO THE ECONOMIC DEVELOPMENT OF ECUADOR: 1897-1986
Authors: Uggen Jonh F.
Published: August 2022

The purpose of this article is to present the history of the Ecuadorian Corporation and its contribution to the economic development of Ecuador, 1897-1986. While much has been written about the construction of the Guayaquil and Quito railroad, relatively little has been written about the connection of the railroad to the Ecuadorian Corporation. In the first part of this article emphasis will be placed on the role of Archer Harman in organizing the railroad construction companies and the railroad’s subsidiary companies between 1897 and 1910. In the second part emphasis will be placed on the role of Evermont Hope Norton in the organization of the Ecuadorian Corporation as a holding company for the subsidiary companies of the railroad. The third and final part of the paper will focus on the role of Norton’s grandson Hope Norton Stevens in the management and liquidation of the company from 1861 to 1986. The research for this article is based on a bibliographical review of the primary and secondary sources on the Ecuadorian Corporation and the Guayaquil and Quito Railroad.
Öğretimi Farklılaştırmayı Güçleştiren Faktörlere İlişkin Öğretmen Algı Envanteri: Geçerlik ve Güvenirlik Çalışması
Authors: BEKLER Ömer , KOZİKOĞLU İshak
Published: August 2022

Bu çalışmanın amacı, öğretimi farklılaştırmayı güçleştiren faktörlere ilişkin öğretmenlerin

algılarını belirlemeye yönelik bir envanter geliştirmektir. Çalışma 320 öğretmenle

gerçekleştirilmiştir. Araştırmada 5’li Likert tipi 45 maddeden oluşan envanter formu

hazırlanmıştır. Açımlayıcı Faktör Analizi sonucunda, envanterin 33 maddeden oluşan altı

faktörlü bir yapı sergilediği ve toplam varyansın %62.968'ini açıkladığı belirlenmiştir. 272

öğretmenle yapılan Doğrulayıcı Faktör Analizi sonucunda, açımlayıcı faktör analizi ile elde

edilen 33 madde ve 6 faktörlü yapının doğrulayıcı faktör analizi ile doğrulandığı saptanmıştır.

Envanterin güvenirliğini belirlemeye yönelik Cronbach Alfa değerleri; birinci faktör için 0.89,

ikinci faktör için 0.85, üçüncü faktör için 0.92, dördüncü faktör için 0.80, beşinci faktör için 0.81,

altıncı faktör için ise 0.85 olarak hesaplanmıştır. Bu değerler envanterin geçerli ve güvenilir bir

veri toplama aracı olduğunu göstermektedir.
COMPARISON OF LICHTENSTEIN AND DESARDA REPAIRS IN INGUINAL HERNIAS IN TERMS OF POSTOPERATIVE CHRONIC PAIN AND RECURRENS; A PROSPECTIVE RANDOMIZED TRIAL
Authors: TURAN Ersin , ARSLAN Kemal , ERENOĞLU Bülent , KERİMOGLU Ramazan Saygin , KÖKÇAM Süleyman Said , KÖKSAL Hande , DOĞRU Osman
Published: August 2022

Objective Patient comfort is an important factor affecting the outcome and success of inguinal hernia repairs. Mesh usage significantly decreases recurrence rate however, the problems due to mesh usage negatively affects the patient comfort. Desarda repair using the body's own tissues has gained importance because it is more physiological and has low recurrence rates. In this study, we aimed to compare Desarda and Lichtenstein repairs in terms of chronic pain and recurrence. Material and Method Patients who were operated on at Konya Training and Research Hospital between October 2010 and February 2014 were included in the study. Randomization was done using the closed envelope method. Desarda repair was performed in the first group (D), and Lichtenstein repair was performed in the second group (L). Both techniques were applied as originally described. 3 questionnaires were used in the assessment of chronic pain. All three questionairres were filled before the operation, after first and third year from the operation. Results 162 people participated in the research. There were 80 people in the Desarda group and 82 in the Lichtenstein group. The median follow up time was 122 (96-145) months. There were 2 cases with recurrence in each groups. Preoperative pain levels were similar. The pain incidence, severity and limited activity were similar in the first and third years. The mean operation time was significantly lower in D group than L group (44.5±3.7 min and 56.7±2.97 min respectively). Complication rates were similar in both groups. Conclusion Desarda technique can safely used for hernia repair with its similar recurrance, complications and chronic pain rates with the most commonly used Lichtenstein technique. Moreover, it is advantageous with physiological closure of myopectineal orifice, being easy to perform, not containing foreign material and being cost-effective.
COVID-19, monkeypox, and the need for vaccines in low- and middle-income countries
Authors: Rodríguez Morales Alfonso J.
Published: August 2022

Over the last two years, the world has faced the challenge and devastation that the Severe Acute RespiratorySyndrome Coronavirus 2 (SARS-CoV-2) and its Coronavirus Disease 2019 (COVID-19) pandemic has imposed,[1] especially to low- and middle-income countries (LMIC) including those from Latin America, as is the case of Colombia.
Descripción histológica de Galleria mellonella
Authors: Garzón Marcela Gómez , León Enciso Jeannette , Parga Jefferson , Padilla Saavedra Laura Daniela , Peñuela Franco Diana , Pinzón Ruiz Carlos Esteban , Lugo Cohetato Didier Javier
Published: August 2022

Introducción: Las larvas de Galleria mellonella están siendo utilizadas como modelo animal para estudiar enfermedades infecciosas. Para evaluar microscópicamente las interacciones huésped-patógeno in vivo se requiere un correcto procesamiento histológico de las larvas que permita obtener buenos cortes para valorar los cambios que se generan durante la infección. Los investigadores requieren conocer la histología normal de la larva para determinar si el patógeno es capaz de generar enfermedad y si los nuevos tratamientos son efectivos. Objetivo: Este estudio tuvo como objetivo presentar el procedimiento de fijación y técnica histológica de las larvas de Galleria mellonella que realizamos de rutina en el laboratorio Técnica Histológica de la FUCS y la descripción histológica de larvas normales.  Métodos: Las larvas de Galleria mellonella fueron fijadas con 100 ????L de FAATD y se realizaron cortes transversales y longitudinales, que fueron procesados de manera automatizada, en el procesador de tejidos Technicon Doble modelo 2ª. Las larvas pasaron a la central de inclusión para darle una figura tridimensional al casete y finalmente a cortes finos en el micrótomo. Se realizó la coloración de Hematoxilina Eosina (H&E) y registro fotográfico. Se tomó hemolinfa, se extendió en láminas y se coloreo con Wright para registro fotográfico. Resultados: Mostramos y describimos los órganos y las estructuras normales de la larva que deben analizarse en los estudios de patogenicidad microbiana y evaluación de nuevas moléculas para tratamiento de infecciones.  Conclusión: El estudio histológico presentado es una herramienta que contribuye a la implementación de Galleria mellonella como modelo animal.
Posibilidad, riesgo e incertidumbre: análisis de tendencias en las ciencias de la información
Authors: Arenas Grisales Sandra Patricia , Giraldo Lopera Marta Lucía , Ochoa Gutiérrez Jaider , Tangarife Patiño Ana María
Published: August 2022

En este artículo se presentan los resultados de investigación sobre las tendencias de las ciencias de la información en el marco del proyecto de “Innovación curricular de los programas de pregrado en Archivística y Bibliotecología de la Universidad de Antioquia” de la Escuela Interamericana de Bibliotecología. Se analizan las tendencias sociales que permiten pensar en qué forma factores políticos, educativos, económicos y medioambientales influyen en los contextos en los cuales actúan los profesionales y las instituciones; se identifican las tendencias en la producción científica y académica del campo de las ciencias de la información, para indagar hacia dónde va la investigación; se describen las tendencias en las tecnologías de la información y los datos, caracterizadas por cambios y desarrollos vertiginosos que indican los horizontes de esta área de trabajo, pero que no se constituyen en el único factor determinante de las tendencias; y, por último, se reflexiona sobre las tendencias en las instituciones, cómo ellas responden a esas transformaciones y demandas sociales y tecnológicas. El método implementado en la investigación tuvo un enfoque principalmente cualitativo, se usaron tres técnicas de investigación: 1) el análisis de redes sociales de la producción científica, 2) la consulta de comunicados de organismos multilaterales e instituciones del área, el análisis de fuentes de mercado y 3) el desarrollo de entrevistas en profundidad con especialistas en el tema. Se concluye que el desarrollo tecnológico y el rol de los profesionales e instituciones de la información y la memoria demandan cambios constantes y abruptos para la adopción de nuevas tecnologías. Sin embargo, se debe tener cuidado con ello; hay que asumir una posición crítica y consciente, que no desconozca las bases de los campos de conocimiento ni las prácticas sociales y culturales a las que se enfrentan los profesionales.
Effect of Dependency on the Estimation of P[Y<X] in Exponential Stress-strength Models
Authors: Patil Dipak , U. V. Naik-Nimbalkar  , M. M. Kale
Published: August 2022

We consider an expression for the probability R=P(Y<X) where the random variables X and Y denote strength and stress, respectively. Our aim is to study the effect of the dependency between X and Y on R. We assume that X and Y follow exponential distributions and their dependency is modeled by a copula with the dependency parameter theta. We obtain a closed-form expression for R for Farlie-Gumbel-Morgenstern (FGM), Ali-Mikhail-Haq (AMH), Gumbel's bivariate exponential copulas and compute R for Gumbel-Hougaard (GH) copula using a Monte-Carlo integration technique. We plot a graph of R versus theta to study the effect of dependency on R. We estimate R by plugging in the estimates of the marginal parameters and theta in its expression. The estimates of the marginal parameters are based on the marginal likelihood. The estimates of theta are obtained from two different methods; one is based on the conditional likelihood and the other on the method of moments using Blomqvist's beta. Asymptotic distribution of both the estimators of R is obtained. For illustration purpose, we apply our results to a real data set.
Prior Choice for the Variance Parameter in the Multilevel Regression and Poststratification Approach for Highly Selective Data. A Monte Carlo Simulation Study.
Authors: Bruch Christian , Felderer Barbara
Published: August 2022

The multilevel and poststratification approach is commonly used to draw valid inference from (non-probabilistic) surveys. This Bayesian approach includes varying regression coefficients for which prior distributions of their variance parameter must be specified. The choice of the distribution is far from being trivial and many contradicting recommendations exist in the literature. The prior choice may be even more challenging when data results from a highly selective inclusion mechanism, such as applied by volunteer panels. We conduct a Monte Carlo simulation study to evaluate the effect of different distribution choices on bias in the estimation of a proportion based on a sample that is subject to a highly selective inclusion mechanism.
Scientiﬁc and Theoretical Characteristics of the Stage of a Disciplinary Case Consideration and Decision-Making
Authors: Leshchina E. L.
Published: August 2022

The paper is devoted to the characteristics of legal relations arising at the stage of consideration of a disciplinary case and decision-making within the framework of disciplinary proceedings brought against civil servants. The study explains the content of this stage, mental and practical operations, procedural actions undertaken to establish objective truth in an individual and specific case, the final legal assessment of the established facts and circumstances by the person in charge.

The paper substantiates that a disciplinary case consideration and decision making constitutes a stage of proceedings in a disciplinary case or legal proceedings based on materials about a gross disciplinary offense that includes considering the case on the merits in order to establish factual and legal basis of the case and to make a lawful, fair and reasonable decision. The stage of consideration of the disciplinary case and decision-making involves logical and procedural activity of managers (chiefs), commanders, judges of the garrison military court aimed to establish the correspondence between the circumstances of the disciplinary case and the facts that actually took place (i.e. objective truth), to provide legal qualification of the offense by correlating the actual circumstances and elements of an offence and formulation of conclusions and adoption of decisions based on the circumstances of the case.

The paper states lack of procedural norms ensuring consideration of disciplinary cases and adoption of decisions concerning application of disciplinary penalties in the public service system (with the exception of the military service system), which determines the exact and unswerving adherence by law enforcement officers to the general principles of legal and disciplinary responsibility and the established rules applied to impose disciplinary penalties. A disciplinary case consideration by an authorized person in chief is practically implemented in the study of the proceedings files, performing an internal audit, examining the protocol on gross disciplinary misconduct of a military man. This circumstance presupposes further processalization of the legal enforcement activity under consideration and its regulation by the norms of administrative procedural legislation.
Gender Inequality in Marriage and Family Sphere: Forms of Manifestation and Options for Coping with it
Authors: Mikhaylova I. A.
Published: August 2022

Gender inequality in the marriage and family sphere is most pronounced in the different attitudes of men and women to marriage registration, because it is men who, as a rule, prefer common-law marriage, and women are forced to put up with a model of relationships outside of the marriage, which deprives her of the rights provided for legitimate spouses. The analysis of the negative consequences of this problem allowed us to propose the following. It is necessary to legislatively fix the legal consequences of a long-term cohabitation of a man and a woman for those cases when, due to the death of one of the actual spouses, the marriage cannot be registered, which will contribute to the protection of the rights and interests of the other spouse. One more form of gender inequality is the practice when, in the vast majority of cases, a marriage is dissolved and the child remains in the care of the mother. This may adversely affects the psycho-emotional state of fathers deprived of the opportunity to live with their child, and children who wanted to live with the father, and not with the mother. It is necessary to form a stable judicial position based on the unconditional equality of the rights of the child’s parents, which is why decisions on such cases should be made following a comprehensive study of all the circumstances that testify in favor of both the mother and the father. One more form of gender inequality is a violation of women’s rights. Many fathers evade the payment of alimony for the maintenance of children, which is why the mother is entrusted not only with the upbringing of the child, taking care of his health, education, development, but also with the duty of his property maintenance, the burden of which she bears alone.

The results of the analysis make it possible to conclude that all these forms of gender inequality in marriage and family sphere should be investigated by not only legal science, but also psychology and sociology. It is vital as they have deep psychological, emotional and cognitive foundations that form differently in the minds of men and women and manifest themselves in different ways in their behavior.
Precomatosis condition as a factor of violent death in patients with diabetes mellitus: a rare case report
Authors: Akimov Pavel A.
Published: August 2022

BACKGROUND: Diabetic coma is a common diabetes mellitus complication. The study of carbohydrate status is usually conducted with non-violent death; however, the death of patients with diabetes can occur with various types of violent death. This study aimed to describe and analyze rare expert cases of the circumstances of violent death in patients with diabetes mellitus.
CASE PRESENTATION: This publication presents two cases of the violent death of patients with diabetes mellitus, of which the cause was a precomatous state, which is the beginning of diabetic (hyperglycemic) coma development. The first case was a corpse of a 56-year-old male patient who was found in an apartment in a bathtub with water. The patient died from drowning in freshwater by aspiration. The second case was a 62-year-old male patient who lost control of the car and allowed the vehicle to overturn. The patient died due to a closed craniocerebral injury of the body. In both described cases, the provoking factor was an acute complication of diabetes mellitus in the form of diabetic coma development (precomatosis condition), which was confirmed by the data of a biochemical study of blood, urine, and the vitreous body.
CONCLUSION: One should not forget about the acute complications of diabetes mellitus (diabetic comas) due to its widespread among the population, which can become provoking factors for the onset of violent death. Therefore, conducting a complete laboratory study on patients with diabetes mellitus, even under any circumstances of the case, is recommended.
Sentiment and thematic analysis of faculty responses
Authors:   , Green Colin , Brewe Eric T
Published: August 2022

This project aims to understand physics faculty responses to transitioning to online teaching during the COVID-19 pandemic. We surveyed 662 physics faculty following the Spring 2020 term, of these, 258 completed a follow up survey after the Fall 2020 term. We used natural language processing to measure the sentiment scores of 364 Spring 2020 responses and another 134 Fall 2020 responses of physics faculty from the United States that completed an optional written prompt. Additionally, we determined the change in sentiment scores of the 100 individuals that responded to both surveys. These sentiment scores measured between -1 and 1 for completely negative and completely positive respectively. Sentiment scores after Spring 2020 were slightly positive with a median value of 0.2347. The distribution of sentiment changes was approx- imately normally distributed with a mean centered near zero. Analysis suggests the average sentiment did not change from the initial to followup surveys. To identify major topics within the responses for both surveys, Latent Dirichlet Allocation analysis was applied to the data. The topic distribution for the initial survey is given as: Course Modifications and Technology, Negative Aspects of the Transition - primarily with Labs and Cheating, Exam and Evaluation Difficulties, and Difficulties with Student Understanding. The topics were noticeably different in the follow up survey with: Differences between Fall and Spring, Cooperative learning strategies, Strategies that worked in the remote space, and Benefits of in person labs.
Android software-based tinnitus retraining therapy: efficacy in treatment of refractory tinnitus
Authors: Athavale Aakriti Sanjay , Sahu Pankaj Kumar , Singh Roohie , Natraj Rashmi
Published: August 2022

Background: Tinnitus is described as a perception of sound in the absence of a sound stimulus. Despite the availability of a number of management strategies, the cure for tinnitus remains elusive. Tinnitus retraining therapy (TRT) combines sound therapy with directive counselling to address subjective tinnitus. This study was done to assess the efficacy of TRT in management of subjective tinnitus that is refractory to various tinnitus treatment strategies. The objectives of this study were to assess the efficacy of Android software TRT in management of refractory tinnitus and to observe the association of hearing status on response to TRT.

Methods: Observational, analytical cohort study of 51 patients undergoing smartphone-based TRT. The assessment tools included comprehensive audiometric evaluation, two self -administered questionnaires tinnitus handicap inventory (THI) and tinnitus functional index (TFI) which were assessed at baseline (0), 6 weeks and at 12 weeks of TRT.

Results: Statistical data analysis revealed significant improvement in perceived severity of tinnitus following TRT, reflected by improvement of THI and TFI scores (statistically significant, p<0.05). Mean pure tone average threshold was 22.1Hz. Additionally, no significant association was found between the hearing loss and the severity of tinnitus.

Conclusions: There is significant improvement in self-perceived disability and severity following TRT as measured using THI and TFI. The results confirm the efficacy of TRT in management of patients with refractory tinnitus. 
Serum levels of monocyte chemoattractant protein-1 has no correlation with gender and age in polytrauma
Authors: Balogun Mosimabale , Odeyemi Olubunmi , Oyewole Olugboyega , Ogunrewo Tolulope , Omoyeni Richard
Published: August 2022

Background: Trauma is one of the commonest causes of death among young people with significant increase in morbidity and mortality. Following injuries to tissues, the body responds in an attempt to cause repair of the damaged tissue. Although its significance depends on the interplay of various factors involving neurohormonal and immune responses. Monocyte chemoattractant protein-1 (MCP-1) is a pro-inflammatory chemoattractant produced by the monocyte and causes the further release of chemokines and cytokines needed at the site of tissue injury. It therefore plays a critical role in tissue healing.

Methods: This was a prospective hospital-based study carried out at University College Hospital (UCH), Ibadan. Polytrauma patients admitted through the accident and emergency department that met a defined criteria were recruited and had their blood samples taken into an endotoxin free test tube at 48±2 hours after trauma. MCP-1 levels in the serum were estimated though the human MCP-1 enzyme-linked immunosorbent assay (ELISA) kit. This process was carried out using the ELISA technique based on the producer’s guide.

Results: 110 patients were recruited for the study. There was no significant difference in gender variations in MCP-1 level (t=-0.935, p=0.351). For the male and female variations in MCP-1 levels, it ranges from 10 to 2841 and 22 to 2687 respectively. Likewise, there was no significant relationship in age variations in MCP-1 values (f=0.959, p>0.05).

Conclusions: This study demonstrated no correlation between serum level of monocyte chemoattractant protein-1 with age and gender in polytraumatized patient according to age and gender.
Targeted NGS analysis of the canonical genes in 274 Indian patients with suspected myeloproliferative neoplasms: An Indian diagnostic laboratory’s perspective
Authors: Kelkar Ketki , Anand Siddharth , Somani Nikita , Ramanan Vijay , Ranade Shatakshi , Patil Kunal , Ragte-Wathare Trupti , Gangodkar Priyanka , Khatod Kavita , Agarwal Meenal
Published: August 2022

Myeloproliferative neoplasms (MPNs) are caused by somatic pathogenic variants that stimulate increased production and clonal expansion of CD34 multipotent hematopoietic stem cells. Recent World Health Organization (WHO) diagnostic criteria for the diagnosis of Philadelphia chromosome (Ph) negative MPNs includes detection of mutations in the Janus Kinase 2 (), myeloproliferative leukemia (), and calreticulin () genes. The purpose of this study was to demonstrate the clinical utility of an in-house next-generation sequencing (NGS) assay targeting only these canonical genes for the molecular diagnosis of patients with Ph-negative MPNs.

We tested 274 samples of patients clinically suspected of having Ph-negative MPNs using an in-house developed NGS panel. The assay consists of two parts, a multiplexed PCR and a highly multiplexed NGS workflow capable of handling diverse samples. The assay is capable of simultaneously detecting mutations in exons 12 and 14, exon 9, and exon 10.

Of the 274 samples tested, 49 samples harbored mutations in the gene (48 for the V617F and 1 for exon 12), 31 harbored mutations in the gene, and two harbored mutations in the gene. One sample harbored a mutation each in the and genes. Here, we present the distribution of mutations in an Indian cohort of 274 patients from India with Ph-negative MPNs. Moreover, we have successfully demonstrated the clinical utility of our in-house multiplexed NGS assay for the molecular diagnosis of MPNs with varying mutation depths
Küttner’s tumour of the parotid gland- an uncommon entity
Authors: Panduranga Shruthi , Harisha V
Published: August 2022

Chronic sclerosing sialadenitis also known as ‘Küttner’s tumour’ (KT) is a benign chronic inflammatory condition first described by Küttner, clinically presenting as a firm swelling, often simulating a neoplasm. The condition is usually misrecognised and the correct diagnosis is made after the excision of the gland. Recent evidence suggests that Küttner’s tumor may be characterized by IgG4-related inflammation. An accurate preoperative diagnosis can be made by awareness of the condition, imaging and histopathopathology features, thereby potentially avoiding excision of an otherwise benign condition. Küttner’s tumour most commonly affects submandibular gland. Küttner’s tumour of the parotid and minor salivary glands are extremely rare. We report a case of a 69 year old man with this interesting and uncommon entity affecting the parotid gland.
A case of disseminated candidiasis in an immunocompromised patient masquerading as adrenocortical carcinoma
Authors: Nath Ambili R , Pothen Lillykutty , Jessy M M
Published: August 2022

Disseminated fungal infection is the presence of a fungal pathogen in the blood (fungemia) and/or any other deep-seated site because of hematogenous seeding. Conditions which predispose individuals for disseminated fungal infections include renal failure, following surgical procedures, HIV, neutropenia, hematological malignancies, and long term use of antibiotics, late sepsis and total parenteral nutrition. Candida is the commonest pathogen encountered in disseminated fungal infections. Secondary seeding of the organism can occur as a result of hematogenous spread. Mortality from disseminated fungal disease is high and therefore high index of suspicion, prompt diagnosis and prompt initiation of antifungal therapy is essential this can be prevented by prophylactic medications in patients at high risk and also by definitive treatment when diagnosis is confirmed.
Primary hepatic neuroendocrine tumor with sarcoid like granulomas: A case report
Authors: Kumar Pankaj , Kumar Sunil , Vaiphei Kim , Kumar Rajender
Published: August 2022

Primary hepatic neuroendocrine tumor (PHNET) is a rare entity comprising 0.3% of all neuroendocrine tumors. Tumors coexisting with granulomas are occasionally noted with malignancies in the lymph nodes draining the tumor or within the primary tumor itself. Tumor-related sarcoid reactions are noted only in carcinomas and its association with a NET has been extremely rare.

: We report a case of PHNET in a 63-year male who presented with various comorbidities who was incidentally detected with a liver space-occupying lesion (SOL). Contrast enhanced CT scan of the abdomen revealed a well-defined exophytic mass in the liver involving segment 6. Subsequently, 68Ga DOTANOC PET/CT scanning revealed somatostatin receptor-expressing well-defined lesion measuring 5.1 x 5.0 cm in segment 6 (SUV MAX 19). A diagnosis of either a primary or a metastatic neuroendocrine tumor was made and non-anatomical wedge resection of the tumor was done with a detailed exploration of the abdominal cavity to look for a primary focus that did not reveal any other lesion or mass. Histologically, the tumor was confirmed to be a Neuroendocrine Tumor along with the presence of tumor-related sarcoid like granulomas in the adjoining hepatic parenchyma.

: Diagnosis of a PHNET requires a combination of a negative abdominal survey at the time of the operative procedure, pathologic evaluation of specimen, and a negative imaging workup for extrahepatic NET in both the pre and postoperative settings.
Cumulação de requerimentos de prisão e penhora no cumprimento da sentença que fixa alimentos.
Authors: Tartuce Fernanda
Published: August 2022

Com o objetivo de assegurar a execução do débito alimentar, o CPC/2015 estabeleceu diferentes técnicas processuais para a consecução desse direito, tais como a expropriação e a prisão civil. A doutrina e jurisprudência controvertem acerca da possibilidade de cumulação dessas técnicas processuais no mesmo procedimento, argumentando alguns que os procedimentos são diversos e devem ser mantidos separadamente. Este artigo pretende analisar a exigência de duplo procedimento considerando as normas que disciplinam o tema, os princípios da economia processual, da celeridade e da efetividade do processo e a especial proteção conferida pela Constituição às pessoas que dependem de alimentos para garantir sua dignidade.
Sob o axé de Iemanjá: A interseccionalidade como uma nova forma para as relações entre raça e gênero no direito
Authors: Terra Bibiana , Da Luz Cícero Krupp
Published: August 2022

As relações entre gênero e raça têm sido historicamente propostas de duas formas no direito: como institutos autônomos ou como horizontes de narrativas ideológicas; e, assim, questionáveis. Neste sentido, o objetivo do presente texto é transpassar essas ideias, com uma abordagem interseccional da teoria crítica do direito, pretendendo-se contribuir para a superação dessa lacuna de modo a auxiliar tanto na compreensão da interseccionalidade do movimento feminista no direito quanto nos estudos de feminismo negro. Para tanto, é utilizado o método da revisão bibliográfica, com o referencial teórico construído a partir de teóricas feministas tais como Angela Davis, Djamila Ribeiro e bell hooks. A pesquisa concluiu que é necessário incluir e repensar intersecções como uma necessidade impositiva e propositiva do direito. Esta abordagem interseccional repropõe e, possivelmente, transforma a tendência universalizante/objetificante do direito, cujas interpretações se dirigem a um sujeito supostamente do patriarcado universal, declinando essa noção. Esta interpretação é raramente vista no direito brasileiro, sendo um trabalho original e nunca antes publicado, uma vez que as articulações de gênero e raça no campo jurídico ainda são um tema relegado a subcapítulos ou notas de rodapé nos textos que abordam o feminismo no direito. Ao fim, verifica-se a limitação do trabalho ao campo teórico, deixando em aberto possibilidades de pesquisas para pleitos científicos empíricos porvir que queiram analisar as presentes formas de opressões que atravessam umas às outras no campo do direito, que viemos a abordar pelo conceito da interseccionalidade.
El incumplimiento de obligaciones y deberes en la perspectiva de la teoría ética del contrato
Authors: Caumont Arturo
Published: August 2022

Mientras las miradas tradicionales conciben el contrato como una relación dentro de la cual se instala el conflicto de intereses que tiene a las partes por antagonistas que buscan la prevalencia de su posición individual y la satisfacción de su interés, también individual, la perspectiva de la Teoría Ética centra su atención y su énfasis a partir de una diferente perspectiva analítica, centrada en la concordancia. Usando el lenguaje en una perspectiva analítica el artículo propone una verdadera revolución en la dogmática de las obligaciones contratuales.
Olhar crítico sobre a cidade mercadológica: entre o espaço do capital e o espaço político dos cidadãos
Authors: Fernandes Marilne Thomazello Mendes , Papali Maria Aparecida Chaves Ribeiro , Gomes Cilene
Published: August 2022

O Brasil, nos anos da década de 1990, foi marcado por grandes transformações nas esferas social, econômica e política. O processo de globalização agiu diretamente nas políticas urbanas e no planejamento das cidades. Durante esse período, o planejamento e a gestão urbana passaram a ser conduzidos com base em preceitos neoliberais, que visavam o gerenciamento da cidade conforme os mecanismos de controle de uma empresa, pensando a cidade por meio de um Planejamento Urbano Estratégico. O discurso desse planejamento difunde a ideia de que as cidades contemporâneas no sistema capitalista promovam a competição entre si, apresentando seus atributos de maneira mercadológica e, assim, negando a cidade em sua dimensão de espaço político e social. O objetivo deste trabalho é discutir se os fatores de lazer e culturais servem apenas de atrativo nessa lógica mercadológica, atravessada pelas políticas que irão renovar o espaço urbano, desfavorecendo a construção do espaço político dos cidadãos, dimensão relevante do espaço da sociedade.
Defender direitos humanos é suficiente?
Authors: Tabuchi Mariana Garcia , Dos Santos Andressa Regina Bissolotti
Published: August 2022

A pergunta provocativa enunciada neste trabalho guia uma reflexão sobre o papel ocupado pelos fundamentos dos direitos humanos, não só em suas consequências teóricas, mas também nas práticas de construção, defesa e percepção dos direitos humanos. Aponta-se para a insuficiência da defesa de direitos humanos em suas perspectivas tradicionais, seja a partir da ótica jusnaturalista ou juspositivista, e indica-se a necessidade de se adotar, na esteira de uma teoria crítica, as resistências históricas concretas como os fundamentos dos direitos que elas visam constituir.
Prevenção ou segregação? Covid-19 e a população carcerária em Santa Catarina
Authors: Chersoni Felipe De Araujo , Leal Jackson Silva
Published: August 2022

O objetivo do presente trabalho é analisar as portarias de enfrentamento à pandemia no que tange ao sistema carcerário em Santa Catarina durante os anos de 2020 e 2021, confrontando-as com os protestos realizados em três regiões diferentes do Estado. Esta análise parte da hipótese de que as referidas portarias aumentaram a segregação na qual tais indivíduos vivem, transplantando a dor do sistema de justiça penal para os familiares das pessoas em cumprimento de pena, sobretudo, mães e companheiras dos criminalizados
Informal Economy and Income Distribution in Ecuador During the COVID-19 Pandemic
Authors: Botello Peñaloza Hector Alberto , Guerrero Rincón Isaac
Published: August 2022

This paper seeks to analyze the evolution of labor informality in Ecuador during the coronavirus. The analysis uses microdata from household surveys for 2019 and 2020 to contrast the evolution of informality rate and income. A wage decomposition model is used to estimate the variation in income between the two periods. The results show an annual drop of 11 % in the informal population working a year ago; however, the informality rate rose by 2 %. This behavior is contextualized by a 20 % decrease in the hours worked per week and a 29 % in hourly labor income.
Sobre la demanda de aplicaciones móviles en Colombia
Authors: Barrientos Marín Jorge , Peña Giraldo Carlos
Published: August 2022

Se presenta un método para estimar el número de descargas de aplicaciones móviles y los ingresos generados en el mercado de aplicaciones en Colombia, para dispositivos iPhone comercializadas en la tienda AppStore. Para ello, se toma una muestra de las aplicaciones mejor ubicadas en las listas de aplicaciones pagas y la lista de las de mayor recaudación. Suponiendo que los datos se generan por una distribución de Pareto, la metodología propuesta predice tanto el número de descargas como la recaudación en dólares (US$) de las aplicaciones utilizando solo datos disponibles públicamente. Estos son el ranking de la aplicación en la lista de las aplicaciones pagas, en las de mayor recaudación y el precio de la aplicación. Los resultados indican que, por ejemplo, para las pagas, la ubicada en el primer puesto genera 1053 descargas/día y la app que encabeza la de mayor recaudación genera 19.684 US$/día.
Estratégias de aprendizagem autorreguladas, prorrogação da gratificação acadêmica e sucesso acadêmico de estudantes da área de negócios
Authors: Xavier Rodrigo de Castilho , Antonelli Ricardo Adriano , Martins Meurer Alison Martins Meurer
Published: August 2022

as estratégias autorreguladas de aprendizagem e a prorrogação da gratificação acadêmica se constituem no foco da presente pesquisa. A autorregulação da aprendizagem é uma área do conhecimento presente na Psicologia da Educação e consiste na prática de estratégias de aprendizagem pelos acadêmicos; subdivide-se nos grupos de estratégias cognitivas, metacognitivas e de gestão dos recursos de aprendizagem. A prorrogação da gratificação acadêmica é a postergação de oportunidades por parte dos acadêmicos que possuíam disponibilidade para atender impulsos, com a intenção de ter significativas recompensas acadêmicas que são mais remotas, porém mais importantes. Nessa perspectiva, este estudo teve como objetivo analisar a aprendizagem autorregulada e a prorrogação da gratificação acadêmica com base nos diferentes níveis de sucesso acadêmico de estudantes da área de negócios. Uma pesquisa on-line foi conduzida junto a discentes de duas instituições de ensino superior brasileiras, a partir da qual foram obtidas 74 respostas válidas, analisadas por meio de testes não paramétricos de diferença de grupos. Os principais resultados do estudo apresentam uma diferença nas estratégias metacognitivas adotadas por estudantes de diferentes grupos de rendimento acadêmico. Os resultados também indicam que a prorrogação acadêmica não é diferente em alunos que apresentam maior ou menor rendimento acadêmico. Além disso, observa-se uma diferença positiva entre as estratégias de pensamento crítico e a prorrogação da gratificação. Nessa perspectiva, esses resultados podem ser utilizados pelas instituições como uma ferramenta estratégica para o direcionamento das vivências dos estudantes no que tange à experiência vivenciada no ambiente universitário.
Inmigración y crisis venezolana
Authors: Cerón Julieth , Sierra Lya Paola , Vidal Pavel
Published: August 2022

Esta investigación identifica los efectos del fenómeno migratorio venezolano en un grupo clave de indicadores que aproxima diferentes dimensiones económicas y sociales del departamento de Norte de Santander en el periodo 2012-2019, por medio de un análisis descriptivo y la estimación de un modelo de regresión lineal. Se encontró que casi la totalidad de los indicadores de empleo examinados muestran un marcado deterioro en Norte de Santander, en momentos en que crece el flujo migratorio desde Venezuela, y sobresale un incremento en la demanda de servicios públicos. Se estimó un efecto neto negativo estadísticamente significativo de la migración en el crecimiento económico. La estimación del impacto de la crisis económica venezolana, examinado mediante el canal de comercio exterior, no fue concluyente. El departamento logró suavizar los impactos diversificando los socios comerciales y transformando su canasta exportadora.
Redes de colaboración empresarial para pymes
Authors: Garzón-Posada Andrés Orlando , Jiménez Ramírez Manuel Arturo , Gómez-Campos Luis Alberto
Published: August 2022

Según datos de la Cámara de Comercio de Bogotá a partir de 2019 se ha visto un incremento en el número de empresas que han cancelado sus operaciones. A pesar de una ligera recuperación a principios de 2020, la crisis económica y social desatada por la pandemia de la COVID-19 (SARS-CoV-2) ha sido implacable con el empresariado local y ha afectado principalmente al sector de las pymes. Las tasas de desempleo distrital llegaron al 16,3 % a finales de 2020 y la retracción del PIB local se acercó al 6,4 %. Como alternativa para el incremento de la competitividad y la innovación en las pymes, así como opción para su supervivencia en tiempos de crisis, en las últimas dos décadas alrededor del mundo se ha trabajado e implementado la estrategia de las plataformas colaborativas. El concepto de colaboración empresarial se asocia con la resiliencia económica de las organizaciones humanas al proponer prácticas innovadoras y movilización de recursos en respuesta a las dificultades y retos existentes. En este sentido el presente artículo tiene como propósito hacer una revisión al estado del arte de las redes de colaboración empresarial, exponiendo sus principales características, las fases de su implementación, su formulación, métodos de análisis y aplicaciones prácticas, con el propósito de exponer la conveniencia, alcance y posibles limitaciones de esta estrategia como opción para las pymes locales que permita mitigar su creciente cierre con los impactos económicos y sociales que esto implica. Palabras clave: redes de colaboración, pymes, innovación, crisis
Síndrome no inventado aquí, sabotaje de conocimiento y desempeño innovador
Authors: Chacón-Henao Juliana , Arias-Pérez José
Published: August 2022

A escala mundial las empresas siguen avanzando en la implementación de inteligencia artificial y robotización para el desarrollo tecnológico y la innovación de productos y servicios; sin embargo, para lograrlo con éxito se encuentran con obstáculos internos, como el sabotaje de conocimientos y el síndrome no inventado aquí, que perjudican el desarrollo de nuevos productos. Este estudio analiza la relación entre el sabotaje de conocimientos, el síndrome no inventado aquí y el desempeño innovador y el efecto moderador de la conciencia en torno a la inteligencia artificial y a la robotización. El testeo del modelo de investigación se realizó mediante ecuaciones estructurales en una muestra de empresas manufactureras de media y baja tecnologías y de servicios de Medellín. Se identificó que el síndrome no inventado aquí influye positivamente en el sabotaje de conocimientos y este actúa negativamente sobre el desempeño innovador. Los hallazgos incrementan la literatura sobre un tema emergente en Colombia como el sabotaje de conocimiento e incentiva las investigaciones alrededor del efecto de la inteligencia artificial y la robotización.
La poiesis de la pedagogía
Authors: Naidorf Judith , López Ordoñez Catalina
Published: August 2022

La pedagogía y su definición requiere ser repensada desde su causa, es decir, el “por qué”, y sentida desde una mirada poética, tras la cual su enunciación nunca es neutral ni exenta de ideología. Este texto procura reflexionar y recuperar algunas de las definiciones clásicas y aquellas más recientes, a partir de una amplia indagación en torno a la misma. El objetivo ha sido reconocer y cuestionar las definiciones contextuadas y contrapuestas que considera una indagación teórica, producto de un reconocimiento enlazado con la experticia dada por el quehacer pedagógico como actores educati- vos, mismo que nos lleva a dialogar con diversos autores. Además, propone una ruta para ampliar el camino a través de pensadores y corrientes hegemónicas y subalternizadas, desde una vital revisión que recupere los desafíos de las múltiples perspectivas de género y de la mirada sensible sobre una pedagogía crítica (y revolucionaria) de construcción permanente. De ahí que nos refiramos a la poiesis de la pedagogía como el camino para una actividad productiva, fabricativa, amorosa, de integralidad, social, cultural y política; que, a decir de Gabriela Mistral (2017), habrá que asumirla como praxis deliberada que incumbe al pedagogue y le posiciona desde una mirada libre, ética, estética y espiritual.