bluuebunny/crossref_metadata_2025 huggingface dataset:
EVALUATION OF AMNIOTIC FLUID INDEX AND ITS PREGNANCY OUTCOME IN A TERTIARY CARE CENTER.
Authors: Chittappareddy Hasini , Kumar E Muneendra , Duddalwar Vaidehi , Chidrawar Yogendra
Published: June 2021

Background: Amniotic fluid assessment is an integral part of the antenatal evaluation of pregnancies at risk for an
adverse pregnancy outcome especially in the third trimester.
Methods: This was prospective observational study conducted at tertiary teaching institute from January 2018 to
December 2020.Total 350 patients were included in the study. On the basis of amniotic fluid index (AFI),patients were
categorized in 3 groups, Normal AFI (6-24 cm), oligohydramnios (AFI <5cm) and polyhydramnios (AFI > = 25 cm).
Results were analysed in the form of incidence, mode of delivery and perinatal outcome which includes preterm, low
birth weight,still births,NICU admissions and neonatal deaths in all the 3 groups
Results: Out of 350 patients, there was 270 cases of normal AFI, 57 cases of oligohydramnios and 23 cases of
polyhydramnios.PIH was the most common etiological factor found in oligohydramnios (33.3%) and in polyhydramnios
idiopathic cause (56.5%) was most common.Incidence of NICU admission was 32.4% in oligohydramnios and 55.5% in
polyhydramnios group in comparison to 12.4% in normal AFI group.
Conclusions: Amniotic fluid index is an important part of antepartum fetal surveillance. Abnormalities of AFI are
associated with high perinatal morbidity and mortality and maternal morbidity.
SALIVA AND SALIVAOMICS IN THE DIAGNOSIS OF ORAL AND SYSTEMIC DISEASES: A REVIEW
Authors: Ruth Sherly , Sridevi Koduri , Krishnaveni Buduru , Prasanth Kumar Nalli , Sreekar Katru , Leela Ramani Komma
Published: June 2021

The quest for novel strategies in early disease detection and response to therapy is an essential ongoing process in
health care setups.Along with other body fluids such as blood,mucus,urine,semen and vaginal fluids;saliva can also be
considered for the detection of the disease.The Salivary diagnostics is a dynamic field that is being incorporated as part
of disease diagnosis, clinical monitoring and for making important clinical decisions for patient care. This review
presents the translational value of saliva as a credible clinical diagnostic biofluid in detection, early detection of the
various diseases and response to treatment.
BACTERIAL ISOLATES AND ANTIBIOTIC SENSITIVITY PATTERNS IN CHOLEDOCHAL BILE COLLECTED DURING ERCP: A REPORT FROM CENTRAL INDIA.
Authors: Talha Noor Mohd , Goyal Vishal , Vasepalli Praveen , Jain Mayank , Singh Thakur Bhagwan , Gorie Nishat
Published: June 2021

Temporal shifts have been known to occur in antibiotic sensitivity patterns of organisms causing cholangitis.The aim of
this prospective study conducted on 100 patients of extra hepatic biliary obstruction (EHBO) was to identify the common
microorganisms cultured from bile obtained during Endoscopic retrograde cholangiography and to study their local
sensitivity pattern.Sixty six patients had growth in bile culture,the maximum growths amongst all micro-organisms were
of Escherichia coli (40.9%) and Pseudomonas aeruginosa (40.9%). Growth rates were significantly higher in patients
with non- malignant causes of biliary obstruction than those with malignant causes. Polymixins had the highest
sensitivity to cultured bacteria followed by aminoglycosides and Imipenem.Study of culture & sensitivity pattern helps
in deciding empirical antibiotic therapy in patients with cholangitis and it should be based on local sensitivity patterns
Power Relationship Marketing dalam Bisnis
Authors: Hasan Ali
Published: June 2021

Understanding the motivations of consumers to engage in relationships with marketers is important for both practitioners and marketing scholars. To develop an effective theory of relationship marketing, it is necessary to under¬stand what motivates consumers to reduce their available market choices and engage in relational market behaviour by patronizing the same marketer in subsequent choice situations. This article draws on established consumer behaviour literature to suggest that consumers engage in relational marker behaviour due to personal influences, social influences, and institutional influences. Consumers reduce their available choice and engage in relational market behaviour because they want to simplify their buying and consuming tasks, simple information processing, reduce perceived risky, and maintain competitive consistency and a state of psychological comfort. The willingness and ability of both consumers and marketers to engage in relational marketing will lead to greater marketing productivity; unless either consumers or mar¬keters abuse the mutual interdependence and cooperation. This article examines theoretical contributions to a comprehensive relationship marketing concept. In the modern marketing sciences, that interaction in networks of relationships constitutes both the essence of life itself and the essence of society. Marketing just applying the perspective of its own discipline and not properly considering the context within which marketing operates. The article offers an overview of the contributions to relationship marketing from traditional consumer goods marketing, services marketing, business marketing and base theory for research
Empowerment Strategy Masyarakat Desa Wisata Kebonagung Kecamatan Imogiri Kabupaten Bantul Yogyakarta
Authors: Suharto
Published: June 2021

Research related to community empowerment strategy is taking a case study in Kebonagung tourist village, Imogiri, Bantul Yogyakarta. The purpose of this research is to find the right form of empowerment strategy that aligned with the community. Qualitative research models through the instrument of observation, interviews, and documentation to collect data and facts that occurred in the community based on primary data and secondary data through the data triangulation process. Interviews were conducted by researchers with determining the key person as resources that is the administrator of tourist village and the community. The strategies proposed in this research include cooperation strategy, cultural defection strategy, and conflict strategy through objective structural approaches as well as objective non-structural approaches. The results showed that community involvement in the existence of tourist village from various economic and socio-cultural aspects have a positive impact even though not yet fully. The openness of employment and business opportunity occurred very positively on the participation of the community in the provision of accommodation facilities, but in the social and cultural aspects has not been maximized. Empowerment strategy recommended through this research in order to reach the economic and socio-cultural aspects of the maximum is more priority to the strategy of cooperation in accordance with the culture of rural communities
Potensi Wisata Kulineri dan Pendidikan di Pesona Alam Dusun Sendang Kumitir Desa Kembang Arum Turi Sleman sebagai Daerah Tujuan Wisatawan
Authors: Hadi Wisnu
Published: June 2021

One of the tourism products in Yogyakarta which is now again a trend and developed is educational tours and culinary tours that can complement other tours such as natural attractions and culture. Because the natural and cultural tourism products are very much in Yogyakarta. A lot of information from the print and electronic media that interest tourism such as culinary and education are widely sold in the media because it is a very promising income and certainly increase the regional economic income. One of the educational and culinary tours is the Natural Enchantment Sendang Kumitir Hamlet that has the potential for culinary tourism and education. In this qualitative descriptive research, the researcher exposed the potential that supports tourism. SWOT analysis also explained that this tour should be developed by managers to be bigger because there is still enough land to expand the tour. From the results of the questionnaire data that tourists are enjoying the education and culinary tour because it is supported by the natural atmosphere that is still beautiful and cool because in the middle of the village and surrounded by bark garden is quite wide. In terms of service to tourists considered satisfactory in terms of attractiveness, facilities and human resources or managers in this case employees and owners of this attraction
Model Komunikasi Pemasaran di Pemerintah
Authors: Simabur Lisda Ariani
Published: June 2021

Government Marketing Communication Model: Promotion Mix For Tourism Destinations In West Halmahera District. As One Of The Districts In North Maluku province, West Halmahera Regency has tourism potential, which is rich in beauty on land and at sea. Therefore, to introduce tourism potential to the community, a Marketing Communication Model in the Government is needed (Promotion Mix of Tourist Destination Areas in West Halmahera Regency). This study aimed to determine the integrated marketing communication strategy of the West Halmahera Regency Tourism Office in attracting tourists. This study uses a qualitative descriptive approach with analysis techniques through data collection, data reduction, data presentation, and the final step is concluding. The results found that the West Halmahera Regency Tourism Office's integrated marketing communication strategy uses four promotional mixes. Namely advertising (advertising), public relations (public relations), personal promotion (personal selling), direct marketing (direct marketing), and interactive marketing
Nilai Budaya Tanam Padi sebagai Daya Tarik Wisata
Authors: Syarifuddin Didin
Published: June 2021

West Java is the centre of Indonesian rice production, which contributes 16 per cent of the national rice production. However, these advantages have not contributed to the growing awareness of the younger generation to preserve the rice planting culture. On the basis of these problems, the purpose of this study is to explain how the cultural value of rice planting with the tourist attraction of the Cikondang Traditional Village community. The research method used is a qualitative method, through in-depth interviews and groups, with data reduction analysis and data presentation. The results showed that the rice planting procession was loaded with cultural values and had a tourist attraction. This value is reflected in the value of human nature, the nature of human relations with the surrounding environment, the essence of human position in space and time, the essence of human relations with work and charity and the nature of human relations with other humans. Meanwhile, the attraction of the tour is reflected in the uniqueness, attractiveness, rarity, authenticity, cleanliness and safety
Pengaruh Promosi Internal terhadap Keputusan Pembelian Tamu pada Garden Restaurant Grand Savoy Homann Bidakara Hotel Bandung
Authors: Pranatha Prima Setia Judha
Published: June 2021

Internal promotion is one of the marketing strategies by utilizing messages and media as a means of delivery to achieve the goals of the sales company. This study aims to see any major influence of promotion on guest purchasing decisions at the Garden Restaurant, Grand Savoy Homann Bidakara Hotel Bandung. The research method used is descriptive statistics. The data technique was carried out through literature studies, interviews and questionnaires, where the data were obtained through questionnaires to guests which were distributed to 100 respondents. The sample population in this study were consumers of the Garden Restaurant Grand Savoy Homann Bidakara Hotel Bandung using an accidental sampling technique. The data analysis technique used is multiple linear regression with the help of SPSS. The results showed that overall the Message (X1) and Media (X2) variables, the purchase decision (Y) had quite a positive effect, namely 64.98%. Where the Message variable (X1) has a greater influence, namely 46.34% while the Media variable (X2) is 18.55% based on the results based on path analysis
Pengelolaan Wisata Air Berwawasan Kesehatan Pemetaan Kasus Leptospirosis Faktor Perilaku dan Lingkungan
Authors: Rohman Hendra , Kiswantoro Amin , Adelia Dinda
Published: June 2021

Community behaviour and environmental conditions are very potential for leptospirosis cases. The main source of transmission is strongly suspected to be in the vicinity of residential neighbourhoods that have standing water and the presence of rats. The aims to identify leptospirosis cases, behavioural and environmental factors for empowering the management of health-oriented water tourism. Method: Descriptive with cross-sectional design. Results: People bathing and washing clothes at water sources around the water attractions. The water swallowed while swimming or submerging the body has been contaminated with bacteria. Water tourism managers make efforts to minimize the breeding grounds of rats. Conclusion: Health-oriented management can develop the potential and attractiveness of tourists. A history of water travel can increase the risk of leptospirosis
Implementasi Konsep Responsible Tourism Marketing (RTM) di Desa Wisata Jatimulyo Kabupaten Kulonprogo Yogyakarta
Authors: Dewi Roels Ni Made Sri Puspa
Published: June 2021

Jatimulyo Tourism Village has many natural tourism objects, cultural and is supported by local culinary. The existence of many attractions presents a new problem in the form of competition between attractions that bring tourists as much as possible without regard to the carrying capacity of the environment. The research objective is to identify the marketing plan consisting of marketing mix analysis (7P), STP and the implementation of Responsible Tourism Marketing (RTM). The method of collecting data uses direct observation, interviews and documentation. Determination of the sample using Snowball Sampling with 20 people sampling consisting of managers of tourist attractions and some local community who work on these attractions. Data analysis uses interactive models, namely: data collection, data reduction, data display and drawing conclusions. The results showed that tourism products owned by Jatimulyo Tourism Village strongly support the implementation of the RTM. Tourism activities such as cave trekking, learning local culinary, swimming in waterfalls, take some photos and exploring the village. The application of RTM is a solution to deal with competition between attractions because they have to pay attention to the carrying capacity and nature conservation
Model Kepemimpinan dan Pengembangan Kreativitas dalam Pengelolaan Destinasi Wisata Budaya Saung Angklung Udjo
Authors: Musthofa Budiman Mahmud
Published: June 2021

The rapid cultural development affected by globalization has had many impacts on local cultures in Indonesia. The dynamics of development and setback of cultural management are interesting to study considering that in the current era of the creative economy, culture is the main capital capable of driving the community's economy, one of which is through the development of cultural tourism destinations. Management of tourist destinations and various attractions requires leadership, creativity and support from its culture. This study was conducted through a qualitative method to explore in-depth information about the leadership model and the development of creativity in the management of cultural tourism destinations through a case study of Saung Angklung Udjo. This research shows that leadership in managing cultural tourism destinations requires creative strength and support from the community and culture in order to achieve long-term success and sustainability. Evidently, for more than 54 years Saung Angklung Udjo has continued to grow and contribute to society and preserve Sundanese culture and become a national pride on the global level
Pengaruh Kualitas Informasi terhadap Keputusan Memilih Objek Wisata dengan Trust sebagai Variabel Intervening
Authors: Maulana Husnul Fuad
Published: June 2021

The purpose of this study is to analyze and discuss the influence of information quality on the decision to choose attractions with trust as an intervening variable. The sampling technique used was non-probability sampling with a purposive sampling method. The population in this study is the age category 17-40 years which is infinite who has become followers of @folkindonesia with a sample of 220 respondents. The questionnaire was distributed online then measured by the Likert scale and path as data analysis. The results showed that the quality of information and trust significantly influence the decision to choose attractions. But not with the information’s quality which doesn’t have a significant direct effect without trust as a mediator on the decision to choose a tourists destination. Furthermore, this study also found that information quality has a significant effect on trust. Meanwhile, based on the Sobel test results trust variable succeeded in mediating the relationship between the information quality variable on the decision to choose a tourists destination
Estado nutricional de estudiantes en el municipio de Colcapirhua.
Authors: Orellana Aguilar Maria Lorena , Rojas Terrazas Luis Fernando , Mamani Rosas Ana Maria
Published: June 2021

Introducción. El estado nutricional se define como la situación en la que se encuentra un individuo con respecto a la ingesta y los ajustes fisiológicos. Estos tienen lugar después de la absorción de los nutrientes y son suficientes para cubrir el gasto dado por las necesidades nutricionales por edad, sexo, características fisiológicas y actividad física. El objetivo del trabajo es evaluar el estado nutricional de los alumnos de las escuelas primarias y secundarias del municipio de Colcapirhua en el departamento de Cochabamba. Metodología. El trabajo es descriptivo, transversal, observacional y prospectivo; Se examinaron 7122 estudiantes de 5 a 19 años de unidades educativas. Resultados. Los problemas por exceso llegan al 33%, de los cuales el 8,1% corresponden a varones con sobrepeso, mientras que las mujeres representan el 9,6% y los hombres con obesidad 9.6% y las mujeres el 6%. Los problemas de déficit llegan al 3,2%, de los cuales el 2% corresponde a varones con desnutrición / anemia, mientras que las mujeres representan el 1% y desnutrición severa con anemia para ambos sexos el 0,2%. Discusión. Los datos muestran que el sobrepeso se duplica, la diferencia en obesidad es desastrosa y el bajo peso también es diferente. Por lo tanto, el estudio muestra que los resultados han cambiado significativamente durante un período de alrededor de 6 años. En resumen, se puede decir que, con base en los diagnósticos establecidos, el riesgo de malnutrición debe ser reconocido temprano sin esperar a que ocurra el problema.
EVALUATION RESULTS OF THE USE OF MODERN INTERNET SOURCES BY THE STUDENTS OF VOCATIONAL EDUCATION INSTITUTIONS FOR THE FORMATION OF HEALTH AWARENESS
Authors: Brych Valeriya V. , Dudash Habriella V. , Bilak-Lukyanchuk Viktoria Y. , Dub Mariana М. , Hutsol Ivanna Y.
Published: June 2021

The aim: Is toevaluate students’ use of online tools to obtain information on health and healthy lifestyle.
Materials and methods: A sociological survey was conducted among 1,563 students of vocational education institutions in Transcarpathian region, using a specially designed questionnaire on the use of information and communication channels to inform about health and healthy lifestyle.
Results: It was found that a large proportion of students of vocational education institutions (71.8 ± 2.2%) spend more than 2 hours a day browsing Internet resources, which makes it possible to use these information and communication channels to inform about health and healthy lifestyle. The most relevant sources of information about health for young people are social networks Facebook (58.3±2.4%) and Instagram (56.7±2.5%), webpages of famous doctors (34.9±2.4%) and official websites of health care institutions (32.4±2.3%).
Conclusions: Effective use of modern information and communication channels for health promotion among students aged 15-18 is possible taking into account the preferences of the target group, their features, reliable information content.
QUALITY OF LIFE DETERMINANTS IN PERSONS WITH DISABILITY AFTER MUSKULOSCELETAL INJURIES
Authors: Detsyk Oryna D. , Yukish Halyna Y. , Tsikhon Zoya O. , Kovalchuk Rostyslav Y. , Karpinets Ihor M.
Published: June 2021

The aim: To study the intrinsic and extrinsic factors affecting quality of life in persons with disability after musculoskeletal injuries.
Materials and methods: A medical and social research was conducted on151 individuals with re-confirmed disability after musculoskeletal injuries.
Results: It was found that a third of people with disabilities after musculoskeletal injuries (35.8±3.9%) has low quality of life (QoL), females more often than males (OR = 2.73; 95% CI: 1.33-5.59). The following physical determinants of low QoL were identified: severity of disability group (2.77; 1.29-5.92), severity of injury (2.73; 1.11-5.63) related to long-term inpatient treatment (6.36; 2.55-15.86) and need of special tools for rehabilitation (2.42; 1.20-4.92). It was found that QoL in people with disability is decreasing with unemployment (4.44; 2.13-9.23) and reduction in social interaction (2.67; 1.33-5.39) when living with children (3.04; 1.50-6.16), complicated relationship (5.28; 2.54-10.97) and no support in family (3.25; 1.62-6.50). This is accompanied by an increase in the need of psychotherapy (4.07; 2.10-8.24), risky alcohol consumption (3.29; 1.19-9.07) and taking of sedative drugs (2.97; 1.35-6.50). It was established such medical and social determinants of low QoL as inadequate awareness of persons with disability about content of their Individual rehabilitation program (3.85; 1.69-8.76), insufficient covering of special tools (3.41; 1.67-6.96) and dissatisfaction of rehabilitation efficacy (3.79; 1.55-9.28).
Conclusions: It is necessary to improve the system of rehabilitation of persons with disability after musculoskeletal injuries in view of quality of life determinants.
PRIORITY RECOMMENDATIONS FOR SOLVING THE PROBLEM OF CHILDREN OBESITY BASED ON THE RESULTS OF THE RESEARCH
Authors: Ohniev Viktor A. , Pomohaibo Kateryna H. , Kovtun Mihail I.
Published: June 2021

The aim: Of the work was to study and evaluate the risk factors and the level of primary medical care for children with overweight and obesity.
Materials and methods: A sociological survey was conducted in main (413 persons) and control group (396 persons) and the copying from the history of the child’s development (f.112/a) of 280 obese children was conducted.
Results: It was defined that on the development of excess weight in children and adolescents, biological and social and hygienic factors had a significant impact (η ≥ 3%; p<0,001) and that the level of primary medical care for obese children (proved diagnosis of obesity in the history of the child (f. №.112/а) had only 61,7±2,7% of patients) was insufficient.
Conclusions: Identification of comprehensive priority activities for solving problem of children overweight and obesity based on the results of conducted research were done.
PREVENTION OF ASTHENIC SYNDROME AS CONCOMITANT CIRCUMSTАINS IN POST-COVID-19 PATIENTS
Authors: Kireyev Igor V. , Zhabotynska Natalia V. , Vladimirova Inna M. , Ocheredko Lilia V.
Published: June 2021

The aim: Is research into development of asthenic syndrome and its effect on the productivity in post-COVID-19 patients.
Materials and methods: All patients underwent neuropsychological testing immediately after the COVID-19 treatment and one month after a comprehensive rehabilitation program.
Results: The research proved that of all post-COVID-19 patients, who showed signs of asthenic syndrome from predominantly moderate to extreme severity, the patients who followed the complete comprehensive rehabilitation intervention significantly reduced verifiable severity of asthenic syndrome as well as the disability duration.
Conclusions: Early administration of combined rehabilitation methods enables preventing the development of long-term side effects, reduces recovery time and enchases the productivity in post-COVID-19 patients.
SPORT CLASSES AS EFFECTIVE MEANS FOR PSYCHOPHYSICAL HEALTH IMPROVEMENT OF REPRESENTATIVES OF THE SECURITY AND DEFENSE SECTOR
Authors: Okhrimenko Ivan М. , Hrebeniuk Maksym O. , Borovyk Mykola O. , Krasnopolskyi Mykola M. , Rodionov Mykhailo O. , Kuzenko Yurii I. , Korak Yevhenii O.
Published: June 2021

The aim: Is to investigate the influence of sport classes on the psychophysical health of Ukrainian Armed Forces’ servicemen.
Materials and methods: The level of servicemen’s health was estimated according to the professor Apanasenko’s methodology based on the anthropometric and functional indicators. In the research there were 120 cadets aged 18 to 22 from Odesa Military Academy. Methods of research: analysis of scientific works, medical and biological methods, experiment, statistics analysis.
Results: It was found out at the end of the experiment that the health level of the cadets who attended Crossfit classes is significantly higher than that of the cadets who studied according to the standard physical training program. The most profound effect was revealed on the functionality of the cardiovascular, respiratory and muscular systems, and the stabilization of body weight of cadets of experimental groups.
Conclusions:The results of the research show sufficiently high effectiveness of the Crossfit classes for the purpose of improving cadets’ psychophysical health during studying. High psychophysical health level formed during the Crossfit training increases longevity and resistance of the body to unfavourable factors of professional activity, reduces the risk of professional diseases and improves the efficiency of the official duties performance.
SOCIO-PSYCHOLOGICAL DETERMINANTS OF ADOLESCENT HEALTH AT THE INITIAL STAGE OF PROFESSIONAL EDUCATION
Authors: Merkulova Tetiana V. , Peresypkina Tetiana V. , Cherniakova Ganna М. , Nesterenko Valentyna H. , Holubnycha Halyna I. , Holubnycha Olha O.
Published: June 2021

The aim: The aim of research was to determine of socio-hygienic and psychophysiological characteristics of adolescents with different levels of professional readiness at the beginning of professional education.
Materials and methods: Among 451 adolescents aged 15-18 who start vocational training were studied vocational readiness, quality of life related to health, social characteristics, self-assessment of individual psychological and physiological characteristics and needs.
Results: Students of vocational schools have a lower (p <0.05) level of readiness to make decisions and plan future professional activities. Medical students had the highest levels of professional readiness. It was found that (57.5 ± 4.3)% of the studied adolescents did not have a clearly defined hierarchy of life spheres and terminal values. There are no significant differences in the quality of life related to health among students of different educational institutions. The highest indicators of satisfaction of basic needs were observed among students of vocational schools. The level of professional readiness of adolescents who studied in the pedagogical field had a greater impact on their physical functioning and mental health; аmong medical students – social and physical functioning, general and psychological health.
Conclusions:The professional orientation of young students has a significant impact on their health-related quality of life and health-promoting behavior. Students whose behavior depends on external circumstances are a risk group for healthy lifestyle disorders, and their health-preserving behavior is more dependent on the positive impact of the educational environment.
THE ROLE OF GALECTIN-9 IN PATIENTS WITH CHRONIC VIRAL HEPATITIS C AND ITS CONNECTION WITH THE TYPE OF THERAPY, THE DEGREE OF FIBROSIS, CLINICAL, LABORATORY, AUTOIMMUNE AND INTEGRATIVE INDICATORS
Authors: Chemych Mykola D. , Lishnevska Anastasiia G.
Published: June 2021

The aim: To establish the dependence of the concentration of galectin-9(CGal-9) in the serum of patients with chronic viral hepatitis C (CVHC) on the type of antiviral therapy (AVT), clinical-laboratory, autoimmune and integrative parameters, non-invasive methods of assessing the degree of fibrosis.
Materials and methods: CGal-9 in serum were determined in 68 patients with CVHC and 20 healthy individuals, and clinical-laboratory and integrative parameters, noninvasive methods for assessing the degree of fibrosis were studied.
Results:There were three groups: baseline (I), pegylated interferon (PEG-IFN) with ribavirin (II), velpatasvir with sofosbuvir (III). In pations from group I, compared with healthy people, CGal-9 was 1.7 times higher (p <0.05); in patients from group II it was 4.2 times higher (p<0.05); in patients from group III it did not differ from healthy individuals. All patients had a directly proportional correlation between CGal-9 and the frequency of splenomegaly detection; in patients who did not receive AVT, directly proportional – with De Ritis ratio, non-invasive methods of liver fibrosis, inversely proportional – with platelet count (p<0,05). There was a higher probability of positive indicators of antinuclear antibodies (ANA) at 12 weeks of treatment with PEG-IFN and ribavirin, with higher CGal-9 at 4 weeks of AVT (p<0,05).
Conclusions: Correlations between CGal-9 and the frequency of splenomegaly detection, platelet count, De Ritis ratio, degree of lever fibrosis in correlation with METAVIR, APRI, FIB-4, ANA, NI were determined. The possibility of predicting the occurrence of splenomegaly, liver cirrhosis and positive ANA in patients with CVHC has been proven.
THE CHRONIC KIDNEY DISEASE RISK ANALYSIS IN PATIENTS WITH ARTERIAL HYPERTENSION AND COEXISTENT HYPERURICEMIA
Authors: Chernatska Olha M. , Prystupa Liudmyla N. , Fadieieva Hanna A. , Liashenko Alina V. , Pogorielova Oksana S. , Opolonska Nataliia O.
Published: June 2021

The aim: Is the analysis of chronic kidney disease risk in patients with arterial hypertension and coexistent hyperuricemia.
Materials and methods:We observed 40 patients with arterial hypertension and coexistent hyperuricemia (I group), 35 – with arterial hypertension (II group) and 30 practically healthy people (control). The duration of hypertension was 4,3 ± 2,31 years and 4,0 ± 2,11 years (p = 0,9247) for I and II group respectively, of hyperuricemia – 4,1 ± 0,35 years for I group. Categories of albuminuria (А1, А2, А3) and glomerular filtration rate (G1, G2, G3A, G3B, G4, G5) were determined in all observed patients. Clinical, anthropometric, biochemical, immunoassay, statistical (SPSS 21, Graph Pad) methods were used.
Results:The categories of albuminuria and glomerular filtration rate in patients from the I group demonstrated that A1G1 was confirmed in 3 persons, A1G2 – 5, A2G1 – 7, A2G2 – 20, A1G3A – 1, A1G3B – 1, A2G3A – 2, A2G3B – 1. Among patients from the II group category A1G1 was defined in 7, A1G2 – 2, A2G1 – 16, A2G2 – 10 persons. The percent of low chronic kidney disease risk was on 5,7 % higher in hypertensive persons comparable with comorbid persons. High and very high risk was confirmed in 10 % persons from I group and nobody from the ІІ group.
Conclusions:Chronic kidney disease risk is increased in patients with arterial hypertension and coexistent hyperuricemia. This indicates an association between elevated uric acid levels and chronic kidney disease progression.
CULTURAL METHOD IN BABESIOSIS PATHOGENS DIAGNOSIS: CURRENT STATE OF THE PROBLEM
Authors: Torianyk Inna I.
Published: June 2021

The aim is to show the effectiveness of the cultural method in the diagnosis of babesiosis.
Materials and methods: The study material was the blood from 10 healthy humans and animals, 30 humans with borreliosis, 41 animals with babesiosis. A cultural research method was used.
Results: The use of cultural method contributed to the optimization of the etiopathogenetic diagnosis of babesiosis. The method objectively proved the ability of protozoa (Babesia spp.) to asexual reproduction in vitro on the multicomponent growth medium with erythrocytes; proved the role of erythrocytes as acceptable for Babesia spp. of target cells. Absolute and relative parameters of detection of Babesia spp. by cultural method in the blood samples of the groups of the examined persons/species were different, making on average 19.7% (with the highest rates among the domestic dogs (62.5%) and cattle (20.0%)). Negative result (0%) was identified among the patients with borreliosis.
Conclusions: Detection of Babesia spp. by the cultural method objectively confirmed its value as an apparent laboratory criterion for the etiopathogenetic diagnosis of babesiosis.
THE MEDICAL REFORM: REALITIES AND PROSPECTS FOR UKRAINE
Authors: Меlnychenko Oleksandr A. , Chovpan Ganna O. , Udovychenko Nataliya M. , Muratov Georgii R. , Кravchenkо Zhanna D. , Rohova Olena G. , Kutuzyan Zhanna M.
Published: June 2021

The aim: is to analyze the realities and to determine prospects of the medical reform in Ukraine as a method of public administration of healthcare.
Materials and methods: The given paper uses an integrated approach, which consists in the study of public administration of healthcare as a single whole with the coordinated functioning of all its constituents; besides this, the methods, which were used at the empirical and theoretical levels, such as, an abstract logical method, a method of analyses and synthesis, and a method of comparison were applied in the given research.
Conclusions: The medical reform is not a goal in itself, but when implementing the reform, it is necessary to consider other related processes, such as globalization, technological progress, urbanization, demographic crisis, macro-economic situation, unfinished distribution of the rights of property in business, specialization. Now, there is «The Strategy of the Reformation of Healthcare of Ukraine». And the proper use of the complex of methods of public administration, directed both at balanced growth of the national health field, and prevention of negative influence of related sectors and fields of national economy guarantees its successful realization.
EPIDEMIOLOGY OF MALIGNANT TUMORS OF THE RESPIRATORY ORGANS IN THE TRANSCARPATHIAN REGION DURING 2015-2019
Authors: Feger Olga V. , Pohoriliak Renata Yu.
Published: June 2021

The aim: Study and analysis of the epidemiological situation of malignant neoplasms of the respiratory system at the regional level during 2015-2019. Materials and methods: The study was based on the analysis of data from the state statistical reporting(forms №7, №35 – healthy) and the database of the National Cancer Registry during 2015 – 2019, which was approved by the conclusion of the bioethics commission of Uzhhorod National University (protocol №2/2 of 15.02.2021). Conclusions: The study found an increase in the level of malignant neoplasms of the respiratory system by 17,28%, as well as the uprise in the proportion of malignant neoplasms of the respiratory system in the structure of all tumours, by 11,98%; detection of malignant neoplasms of the respiratory organs in the late stages; the predominance of the death rate of men from MT over women, as well as mortality rate of the respiratory organs MT up to 1 year from the moment of diagnosis among men is higher over women.
MECHANISM OF STATE REGULATION OF MEDICAL RESPONSE TO EMERGENCIES AS AN ELEMENT OF THE CIVIL PROTECTION SYSTEM
Authors: Volianskyi Petro B. , Yakymets Volodymir М. , Terentieva Anna V. , Slabkiy Hennadiy О. , Tverdokhlib Oleksandr S. , Pechyborshch Vyacheslav P.
Published: June 2021

The aim: Conducting a comprehensive analysis on ensuring the mechanism of state regulation of the development of medical emergency response as an element of the civil protection system of Ukraine in the context of dynamic changes of external and internal factors of its functioning.
Materials and methods: The data of the state statistical reporting for the period 2010-2019 and the legislative acts of Ukraine on medical emergency response were used as the materials of study. Bibiliosemantic and statistical method and the method of structural-and-logical analysis were applied in the course of study.
Conclusions: The sustainable socio-economic development of Ukraine should be accompanied by the formation of a safe environment for the society and each individual, guaranteeing an acceptable level of risk and a modern security system based on the principles of international law. The high degree of the Ukrainian industry concentration is currently in a conflict with the low technological discipline of production, which creates objective preconditions for the growth of man-made and technologically-environmental disasters, catastrophes, and other emergencies. Outbreaks of particularly dangerous and infectious diseases, which are of concern not only because of their prevalence but also because of the potential danger to the health of the nation, its economy and international reputation of the state can pose a significant threat to the socio-political and socioeconomic stability of the state. Ukraine is a potentially vulnerable area for epidemics due to a number of natural, geographical and geopolitical factors. Therefore, the health consequences (real and potential) of any emergency are certainly a threat to the national security of Ukraine both directly and due to the extremely negative impact on the socio-economic, socio-political and psychological conditions of the population. Increasing the level of public administration for medical emergency response will increase the effectiveness of emergency response measures.
STRUGGLE AGAINST CHOLERA EPIDEMICS IN IMPERIAL TIME KHARKIV AS A SIGNIFICANT FACTOR OF PUBLIC HEALTH: HISTORICAL EXPERIENCE
Authors: Robak Ihor Yu. , Alkov Volodymyr A. , Demochko Hanna L. , Chernukha Oleksandr V.
Published: June 2021

The aim: The aim of the research is to determine and systematize administrative and medical measures aimed at curbing cholera in the city of Kharkiv in the time of the Russian Empire, to assess the relevance of the experience in fighting the disease, to determine the impact of epidemics and anti-epidemic measures on Kharkiv residents’ public health.
Materials and methods: General scientific and specific historical methods were used, and methods of related sciences were applied as well. The main methods of historical research included, in particular, historical analytical, chronological and comparative historical; methods of medical statistics, etc. The historiography of the issue was analyzed, unpublished archival materials, local press were studied.
Conclusions: Despite the progress made, mortality remained high in general, proving the public health system had to be reorganized. The death rate shocked the local community so much that the authorities had to apply an information blockade. Anti-epidemic components included explanatory work by priests and police, sanitary measures, measures on strict compliance with observation and quarantine, food supplies to the blocked city and free medicine dispensation, involvement of all available medical institutions, and the establishment of special temporary facilities, actual mobilization of medical personnel. It was impossible to act in the other way, because the treatment methods seemed to be ineffective, like today, under the COVID-19 pandemic. When the medical component is proved ineffective in fighting the epidemic, relatively effective administrative measures, tried and tested over the centuries reasonably seem to be useful, and this experience has not lost its relevance.
ASTHMA IN A PATIENT WITH COVID-19: DOES IT PROTECT OR INCREASE THE RISKS?
Authors: Kochuieva Maryna N. , Psarova Valentyna H. , Shklyar Sergey P. , Oparin Aleksey A.
Published: June 2021

The aim: To investigate theimpact of asthma co-morbidity on the susceptibility and clinical course of COVID-19 in asthma patients.
Materials and methods: Electronic databases of Pubmed and Google Scholar were searched using keyword searches.
Conclusions: Despite previous concerns about the increased risk of Covid-19 among asthmatics, most studies have not shown an increase in Covid-19 incidence among asthmatics compared to the general population. A large number of studies that have investigate the role of concomitant asthma in the susceptibility and severity of COVID-19, show conflicting results and indicate numerous factors that may affect these processes, so there is a need for large-scale studies to adjust the result to concomitant factors, which will assess the true impact of asthma on susceptibility and severity of COVID-19. Based on the recommendations of GINA 2020 regarding the management of asthma patients under Covid-19, potential protective effects of asthma therapy and the high risk of exacerbations when discontinuing basic therapy, we consider it appropriate to continue taking asthma patients therapy of asthma during a pandemic.
CORRUPTIVE INCOMINGS LAUNDERING IN THE MEDICAL SPHERE
Authors: Reznik Oleg М. , Bondarenko Olha S. , Utkina Maryna S. , Horobets Nadiia S.
Published: June 2021

The aim: Characteristic of corruptive incomings laundering in the medical sphere and research of components for counteraction to this phenomenon.
Materials and methods: Some methods were used to ensure the completeness and complexity of scientific research: dialectical, formal, legal, epistemological, and systemstructural methods.
Conclusions: It was concluded that corruptive incomings laundering in the medical sphere is becoming commonplace. New ways, means, and schemes for the commission of this crime are appearing. The authors analyze the main methods for corruptive incomings laundering in the medical sphere: during the purchase of medicines and medical equipment, during the procurements of medical preparations and medical equipment, building restoration and renovation, where health care facilities are located, price-fixing and gifting of chief medical officers. A comprehensive system of organizational, legal, and economic measures must be formed that will provide effective counteraction to the corruptive incomings laundering in the medical sphere.
HEALTHCARE IN UKRAINE DURING THE EPIDEMIC: DIFFICULTIES, CHALLENGES AND SOLUTIONS
Authors: Ivats-Chabina Anna R. , Korolchuk Olena L. , Kachur Alexandr Yu. , Smiianov Vladyslav A.
Published: June 2021

The aim: Of this research was to investigate the impact of quarantine restrictions on the health care system in Ukraine, quality of providing and accessibility of health care services for population during quarantine; analyze the influence of economic and social outcomes of epidemy on state of health care.
Materials and methods: For this paper was made a retrospective analysis of COVID-19 morbidity statistics, economic indicators and governmental decrees aimed at resolving the problem of the spreading of coronavirus and ensuring the proper work of medical institutions at all levels of health care. This work includes analysis of data for the period since the beginning of quarantine on the territory of Ukraine in March 2020 till present time.
Conclusions: The complexity of the socio-political and economic situation in Ukraine and the conduct of hostilities in the east of the country have significantly complicated the fight against the spread of coronavirus in the country. Negative changes in the indicators of hospital security were observed both at the secondary level – treatment of patients with COVID-19, and the primary level – primary contact with the patient, primary care, prevention measures. In the long run, this will have significant implications for the individual health of those who have not been able to receive quality care, as well as for public health in general.
PATHOGENETIC MECHANISMS OF COMORBIDITY OF SYSTEMIC DISEASES AND PERIODONTAL PATHOLOGY
Authors: Nemesh Oksana M. , Honta Zoriana M. , Slaba Oksana M. , Shylivskyi Ihor V.
Published: June 2021

The aim: Of the study is to analyze the literary data regarding evaluation of the pathogenetic mechanisms of the interaction of systemic diseases and periodontal tissue damage, conducted on the basis of scientific researches of Ukrainian and foreign scientists.
Materials and methods: Bibliosematic and analytical methods were used in the research. The materials of the exploration are international experience in the study of pathogenetic mechanisms of the interplay of pathology in the cardiovascular, respiratory systems, diseases of the gastrointestinal tract and chronic generalized damage of periodontal tissues.
Conclusions: It is important to search for new modern methods of diagnosis and individual approach to primary and secondary prevention of changes in periodontal tissues on the background of general pathology. The only way to solve this problem is a detailed study of somatic and dental history, changes in all body systems, on the basis of which it is possible to create a reasonable set of individual preventive measures and improve the treatment of periodontal disorders.
REAL-LIFE APPROACHES EMPLOYED BY RECOGNIZED GOVERNMENTS TO ENSURE HEALTH COVERAGE OF CITIZENS IN FRAGILE SETTINGS, INCLUDING THE POPULATION OF THE DISPUTED TERRITORIES, STRUGGLING FOR INDEPENDENCE
Authors: Mariia Yashchenko V. , Tetiana Yurochko P.
Published: June 2021

The aim: To review real-life approaches employed by recognized governments to ensure health coverage of citizens in fragile settings, including the population of the disputed territories, struggling for independence. Materials and methods: Content analysis of documents, the peer-reviewed articles, open-access databases, policy documents and original sources were utilized in order to archive the study aim. Multidimensional approach to source selection was chosen for objective assessment of the current policy- and decision-making practices. Conclusions: Protracted nature of conflict leads to health system fragility resulting in adverse effects on conflict-affected population health coverage. Health policy in such settings is often externally-driven due to lack of capacities of recognized government and reliance on external funding. Safety and political concerns impede imposition of the context-specific durable solutions for the universal health coverage. Recognized governments lack access to real data to perform evidence-based decision-making.Conventional decision-making based on external demand leads to permanent underperformance of health governance.
MENINGO-ENCEPHALITIS IN A MIDDLE-AGED WOMAN HOSPITALIZED FOR COVID-19
Authors: Dyachenko Pavel A. , Smiianova Olha I. , Dyachenko Anatoly G.
Published: June 2021

The aim: To pay attention of clinicians to possible lesions of the central nervous system (encephalitis) in patients with COVID-19.
Case presentation: A 44-year-old woman was admitted to our clinic because of 2-month-history of mild fever, bilateral lower lobe pneumonia, respiratory failure, generalized weakness, and some neurologic symptoms. SARS-CoV-2 RNA was detected in nasopharyngeal swab. Chest CT demonstrated bilateral pulmonary poly segmental consolidations in the mid and lower zones. Focal hyper intensive abnormalities in various parts of the left hemisphere were found at MR brain imaging in T2WI, and T2 FLAIR mode. Cerebrospinal fluid (CSF) examination showed a white cell count of 31/uL (normal <5/uL), protein 0.73 g/L (0.15-0.45), and glucose 1.4 mmole/L (2.2-3.9). Standard CSF neuroviral PCR panel and PCR for SARS-CoV-2 were negative. She was treated with ganciclovir, and dexamethasone. Due to suspected tuberculosis meningitis (cytosis, decreased level of protein and glucose), she also received ex juvantibus a course of anti-TB therapy (isoniazid, kanamycin, and levofloxacin) and made a steady improvement.
Conclusion: This case shows that SARS-CoV-2 in association with other pathogens may cause various lesions of the CNS accompanied by severe neurological manifestations in adults.