bluuebunny/crossref_metadata_2025 huggingface dataset:
Xoo-responsive transcriptome reveals the role of the circular RNA133 in disease resistance by regulating expression of OsARAB in rice
Authors: Xia Kuaifei , Pan Xiaoqing , Zeng Xuan , Zhang Mingyong
Published: July 2023

Upon Xanthomonas oryzae pv. oryzae (Xoo) infection of rice leaves, the invasion induces systematic expression changes for both the coding genes and the non-coding genes, allowing the plant to make corresponding responses. However, the roles of circular RNAs (circRNAs) in rice defending against Xoo remain largely unknown. To address this question, we conducted a whole-transcriptomic analysis to systematically screen the differentially expressed (DE) mRNAs and non-coding RNAs (ncRNAs) in rice responding to Xoo infection. Our results revealed a total of 4076 DE mRNAs, 89 DE long non-coding RNAs (lncRNAs), 82 DE microRNAs (miRNAs), and 14 DE circRNAs identified from Xoo-infected rice plants at 48 h post inoculation. Three circRNAs (ciR52, ciR298, and ciR133) were found to be able to form circular RNAs, and their expression was induced by Xoo infection. ciR133 was found to repress the expression of its parental gene OsARAB (putative arabinofuranosidase gene) during Xoo infection. Overexpression of ciR133 and mutation of OsARAB enhanced rice resistance against Xoo, without compromising main agronomic traits. Our data suggest that circRNAs are associated with rice response to Xoo infection, providing a potential strategy for breeding Xoo-resistant rice plants by manipulating ciR133 and OsARAB.
The future of diagnosis in clinical neurosciences: Comparing multiple sclerosis and schizophrenia
Authors: Misiak Błażej , Samochowiec Jerzy , Kowalski Krzysztof , Gaebel Wolfgang , Bassetti Claudio L. A. , Chan Andrew , Gorwood Philip , Papiol Sergi , Dom Geert , Volpe Umberto , Szulc Agata , Kurimay Tamas , Kärkkäinen Hilkka , Decraene Andre , Wisse Jan , Fiorillo Andrea , Falkai Peter
Published: July 2023

The ongoing developments of psychiatric classification systems have largely improved reliability of diagnosis, including that of schizophrenia. However, with an unknown pathophysiology and lacking biomarkers, its validity still remains low, requiring further advancements. Research has helped establish multiple sclerosis (MS) as the central nervous system (CNS) disorder with an established pathophysiology, defined biomarkers and therefore good validity and significantly improved treatment options. Before proposing next steps in research that aim to improve the diagnostic process of schizophrenia, it is imperative to recognize its clinical heterogeneity. Indeed, individuals with schizophrenia show high interindividual variability in terms of symptomatic manifestation, response to treatment, course of illness and functional outcomes. There is also a multiplicity of risk factors that contribute to the development of schizophrenia. Moreover, accumulating evidence indicates that several dimensions of psychopathology and risk factors cross current diagnostic categorizations. Schizophrenia shares a number of similarities with MS, which is a demyelinating disease of the CNS. These similarities appear in the context of age of onset, geographical distribution, involvement of immune-inflammatory processes, neurocognitive impairment and various trajectories of illness course. This article provides a critical appraisal of diagnostic process in schizophrenia, taking into consideration advancements that have been made in the diagnosis and management of MS. Based on the comparison between the two disorders, key directions for studies that aim to improve diagnostic process in schizophrenia are formulated. All of them converge on the necessity to deconstruct the psychosis spectrum and adopt dimensional approaches with deep phenotyping to refine current diagnostic boundaries.
Prospective Correlation of Magnetic Resonance Tumor Regression Grade With Pathologic Outcomes in Total Neoadjuvant Therapy for Rectal Adenocarcinoma
Authors: Hall William A. , Li Jiahe , You Y. Nancy , Gollub Marc J. , Grajo Joseph R. , Rosen Mark , dePrisco Greg , Yothers Greg , Dorth Jennifer A. , Rahma Osama E. , Russell Marcia M. , Gross Howard M. , Jacobs Samuel A. , Faller Bryan A. , George Sagila , Al baghdadi Tareq , Haddock Michael G. , Valicenti Richard , Hong Theodore S. , George Thomas J.
Published: July 2023

PURPOSE

Total neoadjuvant therapy (TNT) is a newly established standard treatment for rectal adenocarcinoma. Current methods to communicate magnitudes of regression during TNT are subjective and imprecise. Magnetic resonance tumor regression grade (MR-TRG) is an existing, but rarely used, regression grading system. Prospective validation of MR-TRG correlation with pathologic response in patients undergoing TNT is lacking. Utility of adding diffusion-weighted imaging to MR-TRG is also unknown.

METHODS

We conducted a multi-institutional prospective imaging substudy within NRG-GI002 (ClinicalTrials.gov identifier: NCT02921256 ) examining the ability of MR-based imaging to predict pathologic complete response (pCR) and correlate MR-TRG with the pathologic neoadjuvant response score (NAR). Serial MRIs were needed from 110 patients. Three radiologists independently, then collectively, reviewed each MRI for complete response (mriCR), which was tested for positive predictive value (PPV), negative predictive value (NPV), sensitivity, and specificity with pCR. MR-TRG was examined for association with the pathologic NAR score. All team members were blinded to pathologic data.

RESULTS

A total of 121 patients from 71 institutions met criteria: 28% were female (n = 34), 84% White (n = 101), and median age was 55 (24-78 years). Kappa scores for T- and N-stage after TNT were 0.38 and 0.88, reflecting fair agreement and near-perfect agreement, respectively. Calling an mriCR resulted in a kappa score of 0.82 after chemotherapy and 0.56 after TNT reflected near-perfect agreement and moderate agreement, respectively. MR-TRG scores were associated with pCR ( P < .01) and NAR ( P < .0001), PPV for pCR was 40% (95% CI, 26 to 53), and NPV was 84% (95% CI, 75 to 94).

CONCLUSION

MRI alone is a poor tool to distinguish pCR in rectal adenocarcinoma undergoing TNT. However, the MR-TRG score presents a now validated method, correlated with pathologic NAR, which can objectively measure regression magnitude during TNT.
The Value of Targeting CXCR4 With 68Ga-Pentixafor PET/CT for Subtyping Primary Aldosteronism
Authors: Zheng Yanqing , Long Tingting , Peng Ning , Zhen Mengling , Ye Qianwen , Zhang Zhen , He Yao , Chen Zhi , Gan Yu , Luo Min , Li Chun , Liu Zehao , Guo Min , Wang Min , Luo Xianghang , Hu Shuo , Liu Longfei , Jiang Tiejian
Published: July 2023

Context

Primary aldosteronism (PA) is one of the leading causes of secondary hypertension, and its diagnostic subtyping consistently presents a clinical challenge.

Objective

This study aimed to investigate the potential of 68Ga-Pentixafor positron emission tomography/computed tomography (PET/CT) in PA classification and its applicability in guiding the development of clinical treatment plans by increasing the sample size.

Methods

We prospectively enrolled 120 patients with either PA or nonfunctional adenoma (NFA) for analysis. All patients underwent 68Ga-Pentixafor PET/CT. Of these, 11 patients underwent adrenal venous sampling (AVS), 77 underwent adrenalectomy, 76 received pathological diagnoses, and 71 underwent immunohistochemical detection of aldosterone synthase (CYP11B2). Immunohistochemistry for C-X-C chemokine receptor 4 (CXCR4) was performed in 62 cases. Follow-up was conducted for all patients.

Results

Among the 120 patients, 66 were diagnosed with aldosterone-producing adenoma (APA), 33 with idiopathic hyperaldosteronism (IHA), and 21 with NFA. For APA patients, the sensitivity, specificity, and accuracy of visual analysis using 68Ga-Pentixafor PET/CT were 92.40%, 94.40%, and 93.33%, respectively. Furthermore, for APA patients with a nodule greater than 1 cm in diameter, when the maximum standard uptake value was 7.3 or greater, the specificity was 100%; and for APA patients with a nodule less than 1 cm in diameter, 68Ga-Pentixafor PET/CT also exhibited high sensitivity. AVS was successfully performed in 5 patients. Among the 5 patients, the concordance rate between the AVS and 68Ga-Pentixafor PET/CT for PA subtyping was 60%. In the 77 patients who underwent adrenalectomy, 61 PET/CT scans displayed positive lesions, all of which benefited from the surgery. Additionally, the concordance rate between 68Ga-Pentixafor PET/CT imaging and CYP11B2 was 81.69%.

Conclusion

68Ga-Pentixafor PET/CT is a reliable and noninvasive functional imaging technique that demonstrates high accuracy in classifying PA and provides valuable guidance for clinical treatment decision-making.
Διοίκηση ανθρώπινου δυναμικού στον Δημόσιο τομέα. Παρακίνηση και ικανοποίηση των υπαλλήλων της Περιφέρειας Κεντρικής Μακεδονίας
Authors: Πολύζος Χρήστος , Χρυσομαλλίδης Χαράλαμπος
Published: July 2023

Σκοπός του άρθρου είναι η μελέτη της παρακίνησης του ανθρώπινου δυναμικού και της πιθανής σύνδεσης με την απόδοση και την ικανοποίησή του. Για αυτό τον λόγο, πραγματοποιήθηκε εμπειρική έρευνα σε εργαζόμενους στην Περιφέρεια Κεντρικής Μακεδονίας. Η πρωτοτυπία της συγκεκριμένης έρευνας έγκειται αφενός στην υψηλή αντιπροσωπευτικότητα του δείγματος των εργαζόμενων που συμμετείχαν στην πρωτογενή έρευνα για τη μελέτη μιας σημαντικής σε μέγεθος και ειδικό βάρος Υπηρεσίας, και αφετέρου στις προτάσεις παρέμβασης για την αποτελεσματική παρακίνηση, δέσμευση και απόδοση του προσωπικού, βάσει των ευρημάτων. Επιπλέον, η πραγματοποίηση της πρωτογενούς έρευνας συνέπεσε μετην πανδημία covid-19, με αποτέλεσμα οι επιπτώσεις για τους εργαζόμενους να συμπεριληφθούν στους σκοπούς της έρευνας.
Λέξεις-κλειδιά: Διοίκηση ανθρώπινου δυναμικού, παρακίνηση, δέσμευση, ικανοποίηση, Περιφέρεια Κεντρικής Μακεδονίας.
The genome sequence of the Heart Moth, Dicycla oo (Linnaeus 1758)
Authors: Sterling Mark , Lees David C. ,   Natural History Museum Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life programme,   Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: July 2023

We present a genome assembly from an individual female Dicycla oo (the Heart Moth; Arthropoda; Insecta; Lepidoptera; Noctuidae). The genome sequence is 936.7 megabases in span. Most of the assembly is scaffolded into 31 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 15.29 kilobases in length. Gene annotation of this assembly on Ensembl identified 19,564 protein coding genes.
Impact of diabetes on COVID-19 patient health outcomes in a vulnerable racial minority community
Authors: Hamaway Stefan , Nwokoma Uchechukwu , Goldberg Michael , Salifu Moro O. , Saha Subhash , Boursiquot Roosevelt
Published: July 2023

Background

Diabetes is a growing health concern in the United States and especially New York City. New York City subsequently became an epicenter for the coronavirus pandemic in the Spring of 2020. Previous studies suggest that diabetes is a risk factor for adverse outcomes in COVID-19.

Objective

To investigate the association between diabetes and COVID-19 outcomes as well as assess other covariates that may impact health outcomes.

Design

Retrospective cohort study of COVID-19 hospitalized patients from March to May, 2020.

Participants

In total, 1805 patients were tested for COVID-19 and 778 tested positive for COVID-19. Patients were categorized into 2 groups: diabetes (measured by an Hba1c >6.5 or had a history of diabetes) and those without diabetes.

Results

After controlling for other comorbidities, diabetes was associated with increased risk of mortality (aRR = 1.28, 95% CI 1.03–1.57, p = 0.0231) and discharge to tertiary care centers (aRR = 1.69, 95% CI 1.04–2.77, p = 0.036). compared to non-diabetes. Age and coronary artery disease (CAD) increased the risk of mortality among diabetic patients compared to patients with diabetes alone without CAD or advanced age. The diabetes cohort had more patients with resolving acute respiratory failure (62.2%), acute kidney injury secondary to COVID-19 (49.0%) and sepsis secondary to COVID-19 (30.1%).

Conclusion

This investigation found that COVID-19 patients with diabetes had increased mortality, multiple complications at discharge, and increased rates of admission to a tertiary care center than those without diabetes suggesting a more severe and complicated disease course that required additional services at time of discharge.
COVID-19 incidence and outcome by affluence/deprivation across three pandemic waves in Ireland: A retrospective cohort study using routinely collected data
Authors: McKeown Declan , McCourt Angela , Hendrick Louise , O’Farrell Anne , Donohue Fionnuala , Grabowsky Laurin , Kavanagh Paul , Garvey Patricia , O’Donnell Joan , O’Connor Lois , Cuddihy John , Robinson Matt , O’Reilly Declan , Staines Anthony , Johnson Howard
Published: July 2023

Background

Since the pandemic onset, deprivation has been seen as a significant determinant of COVID-19 incidence and mortality. This study explores outcomes of COVID-19 in the context of material deprivation across three pandemic waves in Ireland.

Methods

Between 1st March 2020 and 13th May 2021, 252,637 PCR-confirmed COVID-19 cases were notified in Ireland. Cases were notified to the national Computerised Infectious Disease Reporting (CIDR) system. Each case was geo-referenced and assigned a deprivation category according to the Haase-Pratschke (HP) Deprivation Index. Regression modelling examined three outcomes: admission to hospital; admission to an intensive care unit (ICU) and death.

Results

Deprivation increased the likelihood of contracting COVID-19 in all age groups and across all pandemic waves, except for the 20–39 age group. Deprivation, age, comorbidity and male gender carried increased risk of hospital admission. Deprivation was not a factor in predicting ICU admission or death, and diagnosis in wave 2 was associated with the lowest risk of all three outcomes.

Conclusions

Our study suggests that COVID-19 spreads easily through all strata of society and particularly in the more deprived population; however this was not a consistent finding. Ireland is ethnically more homogenous than other countries reporting a larger deprivation gradient, and in such societies, structural racial differences may contribute more to poor COVID outcomes than elements of deprivation.
Influenza vaccination from the perspective of health care workers at university hospitals
Authors: Rykowska Dominika , Sobierajski Tomasz , Okarska-Napierała Magdalena , Wanke-Rytt Monika , Kuchar Ernest
Published: July 2023

Background

The influenza vaccination rate of healthcare workers (HWs) in Poland is low. Before implementing methods for promoting influenza vaccination, it is crucial to identify attitudes towards vaccination. We aimed to examine the knowledge and attitudes towards influenza vaccination of HWs at university hospitals. Moreover, we evaluated the incentives for getting influenza vaccination among HWs.

Methods

From September 2020 to October 2020, we surveyed HWs in one children’s hospital and two adults’ hospitals in Warsaw (Poland). We included only fully and correctly completed surveys into final analysis.

Results

A total of 950 questionnaires (85% women, 45% <40 years old, 33% physicians and 48% nurses, 56% working in a children’s hospital) were evaluated. Of all HWs, 25% declared they were vaccinated and 54% planned to get vaccinated in the next season. We have analyzed attitudes towards influenza vaccination and motivations to get vaccinated.

Conclusions

Among HWs in academic hospitals, males, people <40 years old, physicians and those working in children’s hospital are more likely to get vaccinated and their attitudes towards influenza vaccination are more positive. Of those less likely to get vaccinated, people >40 years old and nurses could be effectively persuaded by free and on-site influenza vaccination. Moreover, free access to vaccination is the strongest motivator for vaccination among all HWs. The attitudes towards mandatory influenza vaccination differ sharply among HWs–while physicians are ready to accept it, nurses are not.

Trial registration

ClinicalTrials.gov Identifier: NCT04569019.
Impact of economic globalisation on value-added agriculture, globally
Authors: Sansika Nadeena , Sandumini Raveesha , Kariyawasam Chamathka , Bandara Tharushi , Wisenthige Krishantha , Jayathilaka Ruwan
Published: July 2023

Economic globalisation is the integration of national economies into the global economy through the increasing flow of goods, services, capital, and technology across borders and it has contributed to garnering a significant portion of most nations’ national income, although its agricultural value-added aspect has yet to be maximised. This pioneering study explores the impact of economic globalisation on value-added agriculture in a global context based on countries’ income levels. Panel data regression with the stepwise method was employed to quantify the impact of economic globalization on agriculture value added in 101 countries between 2000 and 2021. The findings of our study reveal that economic globalisation, through various channels such as fertilizer consumption, employment in agriculture, agriculture raw materials export and import, exchange rate, and foreign direct investment, significantly influences the agricultural value-added factor globally and across different income levels. Furthermore, the results show that agricultural employment significantly impacts the agricultural value-added factor globally and across all income levels. Also, countries with low and lower-middle-income levels significantly affect agricultural value-added due to exchange rates. In comparison, high-income and lower-middle-income levels have an impact due to foreign direct investment. Finally, the upper-middle-income countries have significantly affected agricultural value-added due to agricultural raw materials imports. This study confirms that employment in agriculture, exchange rate and foreign direct investments positively impact agriculture value-added on the global level and based on the income level of countries.
INTERPRETATIVE PHENOMENOLOGICAL ANALYSIS PADA PENGALAMAN BEKERJA SEBAGAI CAREGIVER ADIYUSWA DI PANTI WREDHA (X)
Authors: Purba Stella Giovanni , La Kahija Yohanis Franz
Published: July 2023

Caregiver adiyuswa  merupakan jenis caregiver yang masuk ke dalam kategori pekerja sosial. Pekerja sosial adalah seseorang yang dibayar dalam suatu kemampuan profesional untuk mengadakan tugas konseling maupun perencanaan perawatan dan perlindungan sosial. Dalam hal ini, caregiver adiyuswa bertugas untuk merawat dan melayani para adiyuswa yang tinggal di Panti Wredha. Penelitian ini adalah penelitian fenomenologis yang bertujuan untuk memahami pengalaman bekerja sebagai caregiver adiyuswa. Pemilihan partisipan dilakukan dengan teknik purposive sampling. Penelitian ini menggunakan wawancara semi terstruktur untuk memperoleh data dan menggunakan Interpretative Phenomenological Analysis untuk menganalisis data. Ditemukan delapan tema superordinat, yakni (1) Keputusan bekerja sebagai caregiver, (2) Usaha untuk bertahan dalam pekerjaan, (3) Penerimaan akan kondisi pekerjaan, (4) Responsivitas dalam mengasuh, (5) Skill pengasuhan yang berkembang, (6) Keberhasilan dalam pekerjaan sebagai caregiver, (7) Pekerjaan yang membebani, (8) Kesulitan awal bekerja. Hasil penelitian ini dapat digunakan untuk memahami pengalaman sebagai caregiver adiyuswa dan memberi informasi penting tentang dinamika psikologis pada caregiver adiyuswa.
Investigating environmental impacts of betel nut (Areca chatechu) waste disposal based on human behavior in Port Moresby, Papua New Guinea
Authors: Ono Pendis , Maryono M , Muhamad Fuad
Published: July 2023

The consumption of Areca catechu (betel nut) in combination with Piper betel and lime (calcium hydroxide) in Papua New Guinea has been a daily consumable commodity among the country’s population. Due to the increase usage of betel nut, more wastes tend to be deposited into the city’s environment making the city very filthy. The disposal of wastes along with its end byproducts has become a major problem for the environment due to uncontrolled human behavior and ignorance. The city of Port Moresby has seen a lot of wastes from betel nut husks and salivary spittle being spewed all over public places. The uncontrolled wastes disposal and carelessness of the people has significantly affected the outlook of the surrounding environment. Even though, laws were put in place to manage wastes, people do not care of the impacts and continue to ignore the laws. The study was undertaken to understand human behavior and characteristics towards improper waste management and determine the level of wastes derived from the use of betel nut. The study was conducted using simple random sampling and stratified sampling methods through interviews for qualitative data collection. The results revealed that ignorance and carelessness exist within the population in managing betel nut wastes. The results also indicate that banning the sale and trading of betel nut may lead to social and economic problems for most of the unemployed population in Port Moresby. Therefore, it requires a better approach from the government and the city authorities to develop and implement workable win-win solution to the problems faced by the city residence as well as managing their wastes from the use of betel nut.
ANALISA TEKNIS DAN EKONOMIS PENGGUNAAN COREMAT UNTUK KONSTRUKSI FRP (FIBERGLASS REINFORCED PLASTIC) SANDWICH PADA BADAN KAPAL
Authors: Manik Parlindungan , Hadi Eko Sasmito
Published: July 2023

Planning of ship construction is make its having good effectivity value and efficiency. Composite as material alternative to changes of steel feedstock and wood has many applied named FRP (fiberglass reinforced plastics) single skin. The weakness of this FRP was heavy construction and requires many production time. Therefore, will be checked comparison between single skin with sandwich constructions for shell. In this research, the way for making composite is hand lay up method with three various thickness of skin there are : t, t/2, and t/4. To know strength comparison from the various skin of sandwich with single skin, must be test, consist of tensile test.. The result is analyzed then compared by BKI (Biro Klasifikasi Indonesia) rules for the fiberglass ship. Based on the result, indicates that optimization skin thickness of sandwich construction applies Coremat which tensile strength it is equivalent with Single Skin at 2/3t and usage of Sandwich construction causes 23,12 % lighter. In economic analyze, advantage from low weight is compensation of addition 23,12 % DWT. Material cost for Sandwich about 11,35% bigger than Single Skin construction.
ANALISA PENGELASAN MILD STEEL (ST.42) DENGAN PROSES SMAW, FCAW DAN SAW DITINJAU DARI SEGI KEKUATAN DAN NILAI EKONOMIS
Authors: Hadi Eko Sasmito
Published: July 2023

In this era, the growth of welding technology is very fast, especially in newship building and repairing ship construction. The welding work often rise the delaying which cause of lost of cost, time and material consumables. Developing of speed and efficient welding work have to choose the welding methode to be suitable with site condition. This research will explain the differences of three welding methods consist of SMAW, FCAW and SAW weld methode based on strengthening and economic value. The strengthening of welding result are tested by dectructive test consist of tensile, bending and impact test. It carried out the calculation of weld cost per kgs, weld speed per meter and electrode consumption to know the differences of economic value for all that welding material. The test result showed that no differences of tensile strength between SMAW, FCAW and SAW welding methode, max. 1 %, but SMAW weld methode have yield strength 4 % better than FCAW weld methode and 14 % better than SAW weld methode. FCAW weld methode ductility value 34 % mare than SMAW weld methode and 37 % more than SAW weld methode. FCAW weld methode have economic value 67 % more than SMAW weld methode and 42 % more than SAW weld methode. SAW weld methode on horizontal weld position have speed 63 % more faster than FCAW weld methode and 72 % more faster than SMAW weld methode. SAW weld methode have electrode consumption 6 % more efficient than FCAW weld methode and 50 % more efficient than SMAW weld methode.
PENGARUH BESAR ARUS LISTRIK DENGAN MENGGUNAKAN ELEKTRODA SMAW TERHADAP KEKUATAN SAMBUNGAN LAS BUTT JOINT PADA PLAT MILD STEEL
Authors: Jokosisworo Sarjito
Published: July 2023

The influence of mechanic disposition, is one of the factor influence ship strength. This influence can be test by mechanical test in welding butt joint. The result test database analysis can be conclude that very helpful to increase safety and quality butt joint. With steel specification C= 0,15%, Si= 0,24%, Mn= 0,88%,P= 0,018%, S= 0,034%. This material give a 90, 110, 125 ampere with SMAW AC electrode diameter 3,2 mm x 350 mm with V root and 600 angle In the fabrication of mild steel products, components or equipment, manufacturers employ welding as the principal joining method. Mild steel are weldable materials, and a welded joint can provide optimum corrosion resistance, strength, and fabrication economy. However, designers should recognize that any metal, including stainless steels, may undergo certain changes during welding. It is necessary, therefore, to exercise a reasonable degree of care during welding to minimize or prevent any deleterious effects that may occur, and to preserve the same degree of corrosion resistance and strength in weld zone that is an intheren part of the base metal
KAJIAN POTENSI PERIKANAN TANGKAP DAN PERTUMBUHAN JUMLAH KAPAL TANGKAP ( PURSE SEINE) DI KABUPATEN PEKALONGAN
Authors: Sri Waluyo Bambang
Published: July 2023

In this paper Growing up Catching Vessel every year in District Pekalongan become CPEU Drop in every year. One of Thegreat potential of Indonesian ocean is fishing catch. Cause Indonesia have 17.502 island and have longest margine line island after Canada about 81.000 km, with convention PBB ( UNCLOS ) 1982 Indonesia have 3,1 million km2 and additional 2,7 million km2cause we have ZEEI. The condition make Indonesia have very big Ocean potention fish catching about 6,4 Million ton/year
ANALISA TEKNIS STABILITAS DAN OLAH GERAK KAPAL PATROL SPEED BOAT “GRASS CARP” DI PERAIRAN RAWA PENING JAWA TENGAH
Authors: Kiryanto Kiryanto
Published: July 2023

Patrol Speed Boat merupakan kapal cepat yang digunakan untuk melakukan pengawasan dan patroli demi keamanan suatu wilayah perairan. Dalam pengoperasiannya, kapal cepat Grass Carp digunakan untuk berpatroli di perairan Rawa Pening. Kapal ini dibangun menggunakan konstruksi fiberglass yang ringan dan juga kuat. Banyaknya kasus pencurian ikan dan orang tenggelam di Rawa Pening menjadikan kehadiran kapal cepat memang diperlukan untuk keamanan perairan dan keselamatan orang disana. Grass Carp didesain untuk kecepatan, sehingga faktor teknis kapal seperti stabilitas dan olah gerak menjadi penting untuk dianalisa. Perhitungan stabilitas kapal menggunakan standar yang ditetapkan oleh IMO (International Maritim Organization).Dalam perhitungan stabilitasnya, Grass Carp telah memenuhi semua kriteria dari IMO. Olah gerak kapal dianalisa untuk memperlihatkan gerakan heaving, rolling dan pitching kapal pada saat diam (V = 0 knot) dan pada saat kondisi beroperasi (V = 9,1 knots) ditinjau dari berbagai sudut masuk gelombang dan ketinggian gelombang. Ketinggian gelombang diasumsikan sebesar 0,50, 0,75, 1,00 dan 1,25 meter. Manuver kapal pada sudut maksimum 35° (derajat) memiliki nilai steady turning diameter = 40,85 meter, tactical diameter = 41,63 meter, advance = 27,58 meter, transfer = 20,10 meter dan steady speed in turn = 6,83 knots.
PENGARUH PERBEDAAN POSISI PENGELASAN TERHADAP KEKUATAN SAMBUNGAN T-Joint PENGELASAN FILLET DENGAN LAS FCAW PADA PLAT MILD STEEL
Authors: Jokosisworo Sarjito
Published: July 2023

To get quality of good weld joint that in scheme of construction welder of hull must be planned about way of welder, way of inspection, welding flux and weld type which would in utilizing. By karna to get quality of good weld of welder engineering at ship must be followed by will have an effect on to end result from welder process and mechanical properties yielded at construction welder process of ship steel which in the end will influence strength of construction weld joint of ship steel. How big the influence can be done with assaying of mechanical properties at steel plate weld joint. Data analysis result of the assaying can be taken a a real conclusion assists in increasing grade and security and safety of weld joint. This research aim to know strength of joint T-join at weld material to influence position of welder at buckling strength, and visually with EDSA. By using low alloy steel containing grade C=0,15%, Si=0,24%, Mn=0,88%, P=0,018%, S=0,034%. Material is given [by] treatment of welder with various position of welder Horizontal ( 2F ), Vertical ( 3F ), Overhead ( 4F) by using weld FCAW ( Flux cord Arc Welding) with electrode E71T-1, Ø cord 1,2 mm, applies gas CO2, Pada joint type Tjoin welder fillet. Method used in this research is experiment method, that is experimental method directly to object. In this case steel ST42 joint Tjoin with Thick plate 8 mm Marine Plate 18 piece weld by using gas CO2.To get research data is applied [by] observation method by using testing machine bending and test EDSA. Data which collected then is analysed difference of result from visual and mechanic assaying. Result of research shows existence of difference from strength of bending and its(the visulisation is especially to level of weave bead formed between differences of position of Horizontal ( 2F ), Vertical ( 3F ), Overhead ( 4F). And level of influence position of welder to strain bending 72,65 %.. At execution of workmanship of construction of welder so it will pays attention to weld joint planning which will be used, and position of welder which will be executed, thereby we can determine position of welder which good to facilitating welder process without neglecting quality from weld joint.
PERANCANGAN KAPAL IKAN KATAMARAN DENGAN PENGGERAK MESIN DAN LAYAR DI KABUPATEN REMBANG
Authors: Hadi Eko sasmito
Published: July 2023

Dalam tugas akhir ini direncanakan kapal penangkap ikan purse seine dengan bentuk lambung Katamaran yang efektif dan efisien dari segi teknis, mengingat kapal tradisional yang sudah beroperasi memiliki banyak kerugian dari segi waktu berlayar dan biaya operasional. Perencanaan kapal ini dimulai dengan penentuan parameter-parameter atau batasan-batasan yang sesuai dengan usaha penangkapan yang akan dijalankan. Perencanaan ini menitikberatkan kepada keunggulan kapal ikan Katamaran dibandingkan dengan kapal ikan purse seine tradisional dengan bentuk Mono Hull. Metode formdata digunakan untuk membuat lambung katamaran. Katamaran dirancang dengan mengambil jarak separasi antar demihull S/L = 0,4. dengan metode slender body didapatkan bahwa kapal katamaran mempunyai hambatan 35,65% lebih kecil dari kapal tradisional dengan lambung monohull. Rancang bangun kapal layar motor ini diangkat berdasarkan adanya kelemahan-kelemahan yang terdapat dalam pembangunan kapal secara tradisional di Daerah Rembang dan pemanfaatan potensi sumber daya angin. Pemanfaatan sumber daya angin dengan cara pemasangan layar pada kapal katamaran dapat memberikan dara dorong tambahan hingga 47,3% pada kecepatan angin 20 knot
Design and development of half impulse radiating antenna based ultra wide band system
Authors: Singh Sandeep Kumar , Mitra Sabyasachi , Chandra Romesh , Kalyanasundaram Senthil , Roy Amitava , Sharma Archana
Published: July 2023

An ultra wide band system utilizing Half Impulse Radiating Antenna topology has been designed and developed. A compact Marx generator and a solid dielectric pulse forming line fed the antenna. Based on pulse parameters, frequency range of 250 MHz–1250 MHz is chosen for antenna design. Analytical equations and CST Microwave Studio are used for design and analysis of the Antenna and ultra wide band system. Maximum electric field of 11 kV/m at 20 m distance from source has been measured using half-transverse electromagnetic horn type sensor. This paper discusses both time domain and frequency domain results for the designed UWB system. A good agreement between the simulated and the measured power pattern has been demonstrated in this paper.
Non-monotonic dose-response of di-(2-ethylhexyl) phthalate isolated from Penicillium citrinum XT6 on adipogenesis and expression of PPARγ and GLUT4 in 3T3-L1 adipocytes
Authors: Fauziah Fitra , Ali Hirowati , Ilmiawati Cimi , Ariyanto Eko Fuji , Bakhtra Dwi Dinni Aulia , Mita Deslina Setria , Syafni Nova , Handayani Dian
Published: July 2023

Objectives

Adipogenesis is the fat cell formation process regulated by peroxisome proliferator-activated receptors (PPARγ). The insulin-responsive glucose transporter 4 (GLUT4) has a major role in glucose uptake and metabolism in insulin target tissues (i.e., adipose and muscle cells). The interplay between PPARγ and GLUT4 is essential for proper glucose homeostasis. This study aimed to isolate, elucidate, and investigate the effect of an isolated compound from Penicillium citrinum XT6 on adipogenesis, PPARγ, and GLUT4 expression in 3T3-L1 adipocytes.

Methods

The isolated compound was determined by analyzing spectroscopic data (LC-MS, FT-IR, Spectrophotometry UV–Vis, and NMR). The adipogenesis activity of the isolated compound in 3T3-L1 cells was determined by the Oil Red O staining method. RT-PCR was used to analyze the gene expression of PPARγ and GLUT4.

Results

Di-(2-ethylhexyl)-phthalate (DEHP) was the isolated compound from P.citrinum XT6. The results revealed adipogenesis stimulation and inhibition, as well as PPARγ and GLUT4 expressions.

Conclusions

DEHP showed a non-monotonic dose-response (NMDR) effect on adipogenesis and PPARγ and GLUT4 expression. It is the first study that reveals DEHP’s NMDR effects on lipid and glucose metabolism in adipocytes.
System‐wide optimization of an orthogonal translation system with enhanced biological tolerance
Authors: Mohler Kyle , Moen Jack M , Rogulina Svetlana , Rinehart Jesse
Published: July 2023

Over the past two decades, synthetic biological systems have revolutionized the study of cellular physiology. The ability to site‐specifically incorporate biologically relevant non‐standard amino acids using orthogonal translation systems (OTSs) has proven particularly useful, providing unparalleled access to cellular mechanisms modulated by post‐translational modifications, such as protein phosphorylation. However, despite significant advances in OTS design and function, the systems‐level biology of OTS development and utilization remains underexplored. In this study, we employ a phosphoserine OTS (pSerOTS) as a model to systematically investigate global interactions between OTS components and the cellular environment, aiming to improve OTS performance. Based on this analysis, we design OTS variants to enhance orthogonality by minimizing host process interactions and reducing stress response activation. Our findings advance understanding of system‐wide OTS:host interactions, enabling informed design practices that circumvent deleterious interactions with host physiology while improving OTS performance and stability. Furthermore, our study emphasizes the importance of establishing a pipeline for systematically profiling OTS:host interactions to enhance orthogonality and mitigate mechanisms underlying OTS‐mediated host toxicity.
Reactions of lignin chromophores of the enal and enone type with sulfite
Authors: Lundquist Knut , Parkås Jim , Paulsson Magnus , Heitner Cyril
Published: July 2023

In NaHSO3-solutions of coniferaldehyde and its methyl ether (models for lignin chromophores of the cinnamaldehyde type) a dynamic equilibrium between the aldehydes and their hydrogen sulfite adducts is set up. A comparatively slow addition of hydrogen sulfite to the double bond leading to 1,3-disulfonic acid derivatives occurs; coniferaldehyde reacts slower than its methyl ether. In Na2SO3-solution both aldehydes are rapidly converted to 1,3-disulfonic acid derivatives. The results suggest that in both NaHSO3-solution and Na2SO3-solution the free cinnamaldehydes and sulfite ion are the reactants in the formation of disulfonic acid derivatives. Alkaline treatment of the 1,3-disulfonic acids leads to regeneration of the cinnamaldehydes. On prolonged storage in Na2SO3-solution, the 1,3-disulfonic acid derivative of the methyl ether of coniferaldehyde undergoes reactions leading to colored products and regeneration of the cinnamaldehyde on alkaline treatment fails. A model compound representative of lignin chromophores of enone type (trans-3,3’,4,4’-tetramethoxychalcone) rapidly undergoes addition to the double bond with formation of a sulfonic acid derivative in Na2SO3-solution. Treatment of a second model of enone type, 2,6-dimethoxy-p-quinone, with NaHSO3/Na2SO3-solution results in formation of a sulfonic acid derivative. The reactions of lignin chromophores of the enone and enal types with hydrogen sulfite/sulfite are discussed.
Estratégias de coping e liderança autêntica: atuação do enfermeiro em 2021 durante a pandemia de covid-19
Authors: Bicalho Cleide Straub da Silva , Figueiredo Karla Crozeta , Beltran Rebeca Iwankiw Lessa , Pol Thaiane Almeida Silva , Souza Gabrielle Porfirio
Published: July 2023

Resumo Objetivo identificar a correlação entre as dimensões da Liderança Autêntica e as estratégias de coping utilizadas pelo enfermeiro durante a pandemia. Métodos trata-se de estudo quantitativo, de abordagem descritiva, realizado com 34 enfermeiros atuantes em quatro hospitais de Curitiba. Os dados foram coletados no período de julho a setembro de 2021 de maneira online, utilizando o Inventário de Estratégias de Coping de Folkman e Lazarus e o Authentic Leadership Questionnaire. A análise de dados se deu através dos escores dos domínios de cada instrumento, conforme validação brasileira. Resultados nota-se que as dimensões Processamento Equilibrado e Autoconsciência apresentam correlação positiva moderada com as variáveis Aceitação da Responsabilidade, Suporte Social, Resolução de Problemas e Reavaliação Positiva, sendo que essa última variável apresenta correlação positiva moderada com a dimensão Perspectiva Moral, e a dimensão Transparência Relacional apresenta correlação ínfima com as variáveis de estratégia de coping. Conclusão e implicações para a prática o estudo demonstra que as correlações identificadas estimulam a equipe em circunstâncias de esgotamento, promovendo um comportamento cognitivo equilibrado na condução dos serviços. Observa-se que a correlação entre as estratégias de coping e a Liderança Autêntica na área de enfermagem permitem o engajamento, credibilidade e autodesenvolvimento da equipe.
MODELO DE GESTIÓN ESTRATÉGICA PARA LA SOSTENIBILIDAD DE LAS MIPYMES FAMILIARES DEL DEPARTAMENTO DE SAN MARCOS, GUATEMALA
Authors: Orozco Aroldo Alberto Santistéban , López Jorge Ruperto Rodríguez
Published: July 2023

La globalización y el desarrollo mundial han incrementado la competencia en los mercados y los retos a las empresas, situaciones que se presentan en el Departamento de San Marcos, uno de los puntos comerciales más álgidos e importantes del país. En ese contexto, la sostenibilidad de las MiPymes familiares es importante y compleja, para lo cual carecen de instrumentos específicos; realidad que motivó ejecutar un estudio con el objetivo de diseñar un modelo de gestión estratégica adaptado a sus características y desafíos. La investigación fue de enfoque mixto, se diagnosticó la situación existente, se evaluaron diferentes aportes teóricos y aplicados y se diseñó un modelo mediante la utilización de métodos teóricos y empíricos y principalmente la técnica de la encuesta. Los resultados fundamentales fueron: la revelación de sus deficiencias y amenazas que enfrentan y la creación del modelo proyectado, cuya implementación podría servir a propietarios, directivos y colaboradores para tomar decisiones acertadas y oportunas en la operación de sus negocios, manteniendo el carácter familiar, lo que contribuirá a su estabilidad y al desarrollo económico y social del territorio y del país. En el presente artículo se expone una síntesis del trabajo realizado.
Translation of Peter Handke’s works into Ukrainian (based on the novel “The left-handed woman”)
Authors:   Taras Shevchenko national University of Kyiv, LALAIAN Nataliia
Published: July 2023

The article offers material on the work of the famous Austrian writer Peter Hadke and a translation of his works into Ukrainian. The comparative analysis of one of the most famous works of the author – the story “The left-handed woman” – and its translation into Ukrainian by Oleksa Lohvynenko has been carried out. The strategies used by the translator when reproducing the dominants of the author’s style were analyzed, and it was determined which translation decisions contributed to the adequate reproduction of the original text, and which in some way prevented it. It was found out that O. Lohvynenko successfully reproduced most of the features of the author’s style in the translation: proper names, phraseological units, lexical units with colloquial connotations, author’s syntax. It was noticed that the translator tends to the strategy of “domestication” of translation when reproducing cultural concepts. The “presence of the translator” in the text of the translation is extremely noticeable, in particular due to the increase of emotionality of the translation by introducing additional phraseological units, lexical units of the colloquial register, nouns and adjectives with diminutive and caressing suffixes, as well as through the extraction of semantically important information. Some translation mistakes that led to deviations from the original text and distortion of information were also considered.
ÖĞRENME GÜÇLÜĞÜ OLAN OKUL ÖNCESİ DÖNEMİ ÇOCUKLARINA YÖNELİK BİR DERLEME ÇALIŞMASI
Authors: ÇAKMAK Selin , ERKOÇ YILDIZ Cansın , KIZILDAĞ Melek
Published: July 2023

Genel özellikleri açısından bakıldığında öğrenme güçlüğü, “bilişsel yetenekleri normal sınırlar içinde veya üstünde olmakla birlikte, öğrenme sorunları yaşanması” olarak tanımlanmaktadır. Bu tanımı açarsak; bireyde dinleme, konuşma, okuma, yazma, akıl yürütme ve matematik yeteneklerinin kazanılmasında ve kullanılmasında önemli güçlükler görülmesidir. Bu bozukluğun tanılanmasında ayırıcı özelliğin, zeka düzeyi normal ya da normal üstü bireylerde görülüyor olması, okul öncesi dönemde bu sıkıntıların göz ardı edilmesi ya da fark edilememesi sonuçlarını beraberinde getirmektedir. Ayrıca öğrenme güçlüğü tanımlanırken okuma, yazma ve matematik alanlarında yaşıtlarından belirgin düzeyde gerilik özelliğinin vurgulanması da bireylerin genel olarak ilköğretim 2. ve 3. sınıflarda sorunlarla yüzleşmelerine neden olmaktadır. Ancak öğrenme güçlüğü sadece okuma, yazma ve matematik alanlarındaki geriliğin dışında bireyin yaşamıyla ilgili tüm alanları etkileyen bir durumdur. Aileler çocuklarında bir farklılık olduğunu çoğu zaman fark ederler. Ancak tam olarak adlandıramadıkları için ileriki yaşlarda bu sorunların geçeceği düşüncesi ile ertelerler. İyi bir gözlem ve yetkin uzman danışmanlığıyla çocukta fark edilen davranışlar, bize bu bozuklukla ilgili çocuğun risk altında olup olmadığını açıklayabilir. Özellikle erken farkındalık için okul öncesi dönemde öğrenme güçlüğü olan çocuklara yönelik çalışmaların yürütülmesi kritik bir öneme sahiptir. Buradan yola çıkarak bu  çalışmanın amacı; okul öncesi dönemindeki çocuklarda öğrenme güçlüğünün sebeplerini, belirtilerini ve erken tanılamanın önemini ortaya koyarak aileler ve diğer tüm eğitim paydaşlarında farkındalık oluşturmaya yönelik bir araştırma ortaya koymaktır. Bu amaç doğrultusunda okul öncesi dönemde öğrenme güçlüğü hakkında yapılmış çalışmalardan yola çıkarak bie derleme yapılmış ve çalışma sonunda önerilerde bulunulmuştur.
Evolution of the diagnosis of erectile dysfunction
Authors: Volokitin Evgenii V. , Kyzlasov Pavel S. , Kuzmin Igor V. , Sokolshchik Michail M. , Mustafayev Ali T. , Efimova Ekaterina V.
Published: July 2023

The third millennium marked an increase in interest in the quality of human life and well-being. Human sexual health has become an integral part of a harmonious life. Great interest in the problem of erectile dysfunction is due to the increase in the number of patients with this pathology in the world. Many scientific studies have made progress in understanding the physio logy of erection. Starting its development from an objective examination, questioning, assessment of psychological history, the diagnosis of erectile dysfunction has stepped to new heights, such as multislice dynamic pharmacocavernosography using 3D modeling and positron emission tomography in combination with visual sexual stimulation or erectogenic pharmacological stimuli. The article presents data on the historical aspects of the study of erectile dysfunction and trends in the development of its diagnosis from ancient times to the present day. The main instrumental research methods that are actively used to diagnose the disease at the present time are described.
Development of an Efficient Ukranian Keyboard Layout using a Genetic Algorithm
Authors: Chumachenko Olena , Burkov Anton
Published: July 2023

The aim of this work is to create a more efficient Ukrainian keyboard layout, as the current most popular layout "ЙЦУКЕН" is more adapted to the Russian language than Ukrainian and is therefore not efficient. A mathematical model of a genetic algorithm was developed in this study to achieve this goal. The primary measure of layout efficiency is the total distance traveled by the fingers during typing. Additionally, the study describes the most common typing methods and variables that determine the keyboard's dimensions. This allows for the adaptation of the algorithm to create a keyboard that meets the needs of each individual user. To assess the efficiency of the newly developed Ukrainian keyboard layout, created using a genetic algorithm, experiments and comparisons with existing layouts are conducted. The results of the experiments demonstrate the advantages of the developed keyboard layout for the Ukrainian language.
Pricing and data science: The tale of two accidentally parallel transitions
Authors: Wallusch Jacek
Published: July 2023

Accidentally parallel at the beginning, the transition to value-based pricing and transition to pricing data science have blended harmoniously, changing the pricing landscape. Using the marketing capability approach, I show that the introduction of pricing data science is costly and requires higher management support. Despite its cost, algorithmic price optimisation allows one to react swiftly to changes in demand. The optimisation process is applied to inherently non-linear, multimodal, and right-skewed pricing data. Presenting the interactions between new computational techniques and value-data pricing, I concentrate on altered perceptions of price elasticity, value-driver estimations, and contract opportunity analysis.
Problematyka małżeństw mieszanych katolicko-ewangelickich oraz konwersje na Mazurach w latach 1850–1960
Authors: Kasprzycki Emir
Published: July 2023

Niniejszy artykuł jest próbą przedstawienia problematyki współistnienia dwóch społeczności wyznaniowych na terenie Mazur na przełomie XIX i XX w. Szczególnej analizie poddane zostaną małżeństwa mieszane, zawierane przez przedstawicieli obydwu społeczności oraz związane z tym zjawisko zmiany wyznania (konwersji). Celem autora jest uchwycenie zmian we wzajemnych ewangelicko-katolickich relacjach w kontekście zmieniającej się sytuacji politycznej i demograficznej. W dalszej części podjęta zostanie próba analizy socjologicznej zachodzących zjawisk i ich wpływu na rozpad społeczności ewangelickich Mazurów.