bluuebunny/crossref_metadata_2025 huggingface dataset:
Evolution of V-pits in the ammonothermal growth of GaN on HVPE-GaN seeds
Authors: Li Tengkun , Ren Guoqiang , Su Xujun , Xie Kaihe , Xia Zhenghui , Gao Xiaodong , Wang Jianfeng , Xu Ke
Published: November 2022

The evolution of pit-type defects in the Am-GaN growth of GaN on HVPE-GaN is investigated in this paper.
Four modifications of the Jahn–Teller effects. The problem of observables: spin–orbit interaction, tunneling splitting, and orientational polarization of solids
Authors: Bersuker I. B.
Published: November 2022

Four kinds of electronic degeneracy or pseudodegeneracy leading to the Jahn-Teller effects.
Maximally valent orbitals in systems with non-ideal bond-angles: atomic Wannier orbitals guided by the Mayer bond order
Authors: De Joydev , N. S. Sujith , Hossain Manoar , Bhattacharjee Joydeep
Published: November 2022

Directed hybrid atomic Wannier orbitals with maximum contribution to net valency derived from the Mayer bond order are proposed as a minimal basis for systems with an arbitrary bond angle. Their orientation indicates the bent nature of covalent bonds.
Correction: Zinc(ii) hydration in aqueous solution. A Raman spectroscopic investigation and an ab initio molecular orbital study
Authors: Rudolph Wolfram W. , Pye Cory C.
Published: November 2022

Correction for ‘Zinc(ii) hydration in aqueous solution. A Raman spectroscopic investigation and an ab initio molecular orbital study’ by Wolfram W. Rudolph et al., Phys. Chem. Chem. Phys., 1999, 1, 4583–4593, https://doi.org/10.1039/A904051J.
Barium hydride activates Ni for ammonia synthesis catalysis
Authors: Gao Wenbo , Wang Qianru , Guan Yeqin , Yan Hanxue , Guo Jianping , Chen Ping
Published: November 2022

Barium hydride activates Ni for ammonia synthesis catalysis showing an activity that is comparable to that of the Cs promoted MgO supported Ru catalyst.
Guiding research in electrochemical CO2 conversion strategies through a systems-level perspective
Authors: Nishikawa Emily , Islam Shamiul , Sleep Sylvia , Birss Viola , Bergerson Joule
Published: November 2022

Life cycle assessment as a decision-making tool in R&D of CO2 conversion technologies. A set of technologies are explored to provide recommendations regarding potential climate impacts. Relevant fundamentals of this type of assessment are provided.
Net-zero transition of the global chemical industry with CO2-feedstock by 2050: feasible yet challenging
Authors: Huo Jing , Wang Zhanyun , Oberschelp Christopher , Guillén-Gosálbez Gonzalo , Hellweg Stefanie
Published: November 2022

This study supports the net-zero transition of the global chemical industry by 2050, especially demonstrating the regional CO2 supply-demand feasibility and providing novel guidance regarding site selection and supply-chain optimization.
Bio-based solvents for polyolefin dissolution and membrane fabrication: from plastic waste to value-added materials
Authors: Ramírez-Martínez Malinalli , Aristizábal Sandra L. , Szekely Gyorgy , Nunes Suzana P.
Published: November 2022

Sustainable fabrication of polyolefin membranes from green solvents to application.
Manganese catalyzed cross-coupling of allylic alcohols and nitriles: an elegant route for access to δ-hydroxynitriles
Authors: Wang Shiliang , Song Dingguo , Shen Feiyang , Chen Rong , Cheng Yuqi , Zhao Chuhan , Shen Qilei , Yin Shuxin , Ling Fei , Zhong Weihui
Published: November 2022

A first example of a manganese pincer complex for synthesis of δ-hydroxynitriles through formal conjugate addition of nitriles with allylic alcohols with 100% atom economy.
Lignin-derivable alternatives to petroleum-derived non-isocyanate polyurethane thermosets with enhanced toughness
Authors: Mhatre Sampanna V. , Mahajan Jignesh S. , Epps Thomas H. , Korley LaShanda T. J.
Published: November 2022

Lignin-derivable non-isocyanate polyurethane thermosets are highlighted as potential alternatives to petroleum-derived analogues with significant enhancement in toughness without compromising other application-specific thermomechanical properties.
Correction: An overview on the role of ZnTe as an efficient interface in CdTe thin film solar cells: a review
Authors: Suthar Deepak , Chuhadiya Sakshi , Sharma Ritika , Himanshu  , Dhaka M. S.
Published: November 2022

Correction for ‘An overview on the role of ZnTe as an efficient interface in CdTe thin film solar cells: a review’ by Deepak Suthar et al., Mater. Adv., 2022, 3, 8081–8107, https://doi.org/10.1039/D2MA00817C.
Ab initio investigation of spin–orbit coupling on structural, electronic, and optical properties for quaternary chalcogenide 2D-layered ACu2BS3 (A = K, Na; B = Bi, Sb) compounds
Authors: Raju N. Prudhvi , Lahiri Saurav , Thangavel R.
Published: November 2022

Two-dimensional (2D) materials have triggered broad interest owing to their unique physical and chemical properties that have pioneering applications in electronic and optical devices.
Biomass-derived nitrogen and sulfur co-doped sheet-like porous carbon for high-performance supercapacitors
Authors: Lu Kun-Lang , Wei Xian-Yong , Mao Fa-Zhan , Zhu Zhi-Juan , Li Zhuang , Yin Fan , Li Jia-Hao , Zong Zhi-Min
Published: November 2022

Nitrogen and sulfur co-doped porous carbon materials with excellent electrochemical performance were prepared using a one-step carbonization and activation method.
1,10-Phenanthroline ring-opening mediated bycis-{Re(CO)2} complexes
Authors: Cañadas Purificación , Pérez Julio , López Ramón , Riera Lucía
Published: November 2022

C–N bond cleavage of pyridine rings bonded to well-definedcis-dicarbonyl Re(i) complexes has been achieved, affording bipy and phen (for the first time) ring-opening products.
New high-precision strong lensing modeling of Abell 2744
Authors: Bergamini P. , Acebron A. , Grillo C. , Rosati P. , Caminha G. B. , Mercurio A. , Vanzella E. , Angora G. , Brammer G. , Meneghetti M. , Nonino M.
Published: November 2022

We present a new strong lensing (SL) model of the Hubble Frontier Fields (HFF) galaxy cluster Abell 2744, at z = 0.3072, by exploiting archival Hubble Space Telescope (HST) multiband imaging and Multi Unit Spectroscopic Explorer (MUSE) follow-up spectroscopy. The lens model considers 90 spectroscopically confirmed multiple images (from 30 background sources), representing the largest secure sample for this cluster field prior to the recently acquired James Webb Space Telescope (JWST) observations. The inclusion of the substructures within several extended sources as model constraints allowed us to accurately characterize the inner total mass distribution of the cluster and the position of the cluster critical lines. We included the lensing contribution of 225 cluster members, 202 of which are spectroscopically confirmed. We complemented this sample with 23 photometric member galaxies that are identified with a convolution neural network methodology with a high degree of purity. We also measured the internal velocity dispersion of 85 cluster galaxies, down to mF160W = 22, to independently estimate the role of the subhalo mass component in the lens model. We investigated the effect of the cluster environment on the total mass reconstruction of the cluster core with two different mass parameterizations. We considered the mass contribution from three external clumps, either based on previous weak lensing studies, or extended HST imaging of luminous members around the cluster core. In the latter case, the observed positions of the multiple images were better reproduced, with a remarkable accuracy of 0.​​″37, a factor of ∼2 smaller than previous lens models, which exploited the same HST and MUSE data sets. As part of this work, we developed and made publicly available a Strong Lensing Online Tool (SLOT) to exploit the predictive power and the full statistical information of this and future models, through a simple graphical interface. We plan to apply our new high-precision SL model to the first analysis of the Grism Lens-Amplified Survey from Space-JWST-Early Release Science (GLASS-JWST-ERS) program, specifically to measure the intrinsic physical properties of high-z galaxies from robust magnification maps.
Simultaneous gas accretion onto a pair of giant planets: Impact on their final mass and on the protoplanetary disk structure
Authors: Bergez-Casalou C. , Bitsch B. , Raymond S. N.
Published: November 2022

Several planetary systems are known to host multiple giant planets. However, when two giant planets are accreting from the same disk, it is unclear what effect the presence of the second planet has on the gas accretion process of both planets. In this paper we perform long-term 2D isothermal hydrodynamical simulations (over more than 0.5 Myr) with the FARGO-2D1D code, considering two non-migrating planets accreting from the same gaseous disk. We find that the evolution of the planets’ mass ratio depends on gap formation. However, in all cases, when the planets start accreting at the same time, they end up with very similar masses (0.9 < mp,out/mp,in < 1.1 after 0.5 Myr). Delaying the onset of accretion of one planet allows the planets’ mass ratio to reach larger values initially, but they quickly converge to similar masses afterward (0.8 < mp,out/mp,in < 2 in 105 yr). In order to reproduce the more diverse observed mass ratios of exoplanets, the planets must start accreting gas at different times, and their accretion must be stopped quickly after the beginning of runaway gas accretion (less than 0.5 Myr), for example via disk dispersal. The evolution of the planets’ mass ratio can have an important impact on the dynamics of the system and may constrain the formation history of Jupiter and Saturn.
Comparison of magnetic energy and helicity in coronal jet simulations
Authors: Pariat E. , Wyper P. F. , Linan L.
Published: November 2022

Context. While non-potential (free) magnetic energy is a necessary element of any active phenomenon in the solar corona, its role as a marker of the trigger of the eruptive process remains elusive. Meanwhile, recent analyses of numerical simulations of solar active events have shown that quantities based on relative magnetic helicity could highlight the eruptive nature of solar magnetic systems.

Aims. Based on the unique decomposition of the magnetic field into potential and non-potential components, magnetic energy and helicity can also both be uniquely decomposed into two quantities. Using two 3D magnetohydrodynamics parametric simulations of a configuration that can produce coronal jets, we compare the dynamics of the magnetic energies and of the relative magnetic helicities.

Methods. Both simulations share the same initial setup and line-tied bottom-boundary driving profile. However, they differ by the duration of the forcing. In one simulation, the system is driven sufficiently so that a point of no return is passed and the system induces the generation of a helical jet. The generation of the jet is, however, markedly delayed after the end of the driving phase; a relatively long phase of lower-intensity reconnection takes place before the jet is eventually induced. In the other reference simulation, the system is driven during a shorter time, and no jet is produced.

Results. As expected, we observe that the jet-producing simulation contains a higher value of non-potential energy and non-potential helicity compared to the non-eruptive system. Focussing on the phase between the end of the driving-phase and the jet generation, we note that magnetic energies remain relatively constant, while magnetic helicities have a noticeable evolution. During this post-driving phase, the ratio of the non-potential to total magnetic energy very slightly decreases while the helicity eruptivity index, which is the ratio of the non-potential helicity to the total relative magnetic helicity, significantly increases. The jet is generated when the system is at the highest value of this helicity eruptivity index. This proxy critically decreases during the jet-generation phase. The free energy also decreases but does not present any peak when the jet is being generated.

Conclusions. Our study further strengthens the importance of helicities, and in particular of the helicity eruptivity index, to understand the trigger mechanism of solar eruptive events.
Adding gamma-ray polarimetry to the multi-messenger era
Authors: Kole Merlin , Iacovelli Francesco , Mancarella Michele , Produit Nicolas
Published: November 2022

Context. The last decade has seen the emergence of two new fields within astrophysics: gamma-ray polarimetry and gravitational wave (GW) astronomy. The former, which aims to measure the polarization of gamma rays in the energy range of tens to hundreds of keV, from astrophysical sources, saw the launch of the first dedicated polarimeters such as GAP and POLAR. Due to both a large scientific interest as well as their large signal-to-noise ratios, gamma-ray bursts (GRBs) are the primary source of interest of the first generation of polarimeters. Polarization measurements are theorized to provide a unique probe of the mechanisms at play in these extreme phenomena. On the other hand, GW astronomy started with the detection of the first black hole mergers by LIGO in 2015, followed by the first multi-messenger detection in 2017.

Aims. While the potential of the two individual fields has been discussed in detail in the literature, the potential for joint observations has thus far been ignored. In this article, we aim to define how GW observations can best contribute to gamma-ray polarimetry and study the scientific potential of joint analyses. In addition, we aim to provide predictions on feasibility of such joint measurements in the near future.

Methods. We study which GW observables can be combined with measurements from gamma-ray polarimetry to improve the discriminating power regarding GRB emission models. We then provide forecasts for the joint detection capabilities of current and future GW detectors and polarimeters.

Results. Our results show that by adding GW data to polarimetry, a single precise joint detection would allow for the majority of emission models to be ruled out. We show that in the coming years, joint detections between GW and gamma-ray polarimeters might already be possible. Although these would allow one to constrain part of the model space, the probability of highly constraining joint detections will remain small in the near future. However, the scientific merit held by even a single such measurement makes it important to pursue such an endeavour. Furthermore, we show that using the next generation of GW detectors, such as the Einstein Telescope, joint detections for which GW data can better complement the polarization data become possible.
Self-powered heterojunction ultraviolet photodetector based on NiO nanosheets/TiO2 nanorods
Authors: Shi Shaobo , Cao Rui
Published: November 2022

The heterojunction ultraviolet photodetectors (UV PDs) were fabricated by growing NiO nanosheets on TiO2 nanorod arrays (NRs) via hydrothermal method and their UV photoresponse properties were examined. The crystal structure, and optical properties of heterojunction were characterized by X-ray diffraction (XRD), Raman, absorption and photoluminescence (PL) spectra. The results of X-ray photoelectron spectroscopy (XPS) valence band (VB) spectrum, Mott–Schottky (M–S) curves and electrochemical impedance spectroscopy (EIS) of heterojunctions reveal the separation and transfer of photo-generated carriers in heterojunction interface. The UV PDs exhibit a large responsivity of 0.54 A/W and a high detection sensitivity of 6.0 × 1012 Jones under 365 nm UV illumination at zero bias.
Nano-voids formation at the interaction sites of shear bands in a Zr-based metallic glass
Authors: Dong Zhenzhen , Wang Dongpeng , Wu Yicheng , Geng Yaoxiang , Chen Fugang , Guo Pingyi , Qiao Yaoxin , Li Xin , Wang Yuxin
Published: November 2022

Understanding the formation mechanism of voids is a significant issue in controlling the catastrophic fracture in the form of shear bands in metallic glasses. Here, using an amplitude-modulation atomic force microscope, we investigated the nano-voids formation at the mutual interaction of shear bands in a Cu50Zr50metallic glass. The results of phase shift revealed higher energy dissipation and more soft zones for the nano-voids. The formation of these nano-voids results from tensile stress concentration caused by the interaction of shear bands, based on the results of finite element simulation. The appearance of nano-voids and stress distribution at the site of shear band interaction is essential in understanding the plastic deformation and fracture of metallic glasses.
Community-associated Methicillin-Resistant Staphylococcus aureus (ca-MRSA) as a Pandemic Pathogen: Risk Factors and Implications for Healthcare
Authors: Gleich Sabine , Kiefer-Trendelenburg Thomas , Schlatterer Kathrin , Napp Matthias , Monecke Stefan , Arnold Andreas , Goering Richard , Strommenger Birgit , Werner Guido , Daeschlein Georg
Published: November 2022

Background A diversity of risk factors for ca-MRSA manifestations has been described so far. Up to date toxic contact dermatitis induced by plants has not been identified as one.

Patients and Methods After intense skin contact with poison ivy in
the US a 24-year-old Afro-American showed pronounced bullous contact dermatitis on the back of
the neck and subsequently massive ca-MRSA furunculitis with proof of
Panton-Valentine-leucocidin (PVL). After travelling to Germany, his German girlfriend
developed a subacute ca-MRSA, PVL-positive superinfection of a mosquito bite at her lower leg.
Both infections required surgical intervention.

Results While the male patient displayed contact dermatitis by poison ivy, the female patient demonstrated two risk factors for ca-MRSA: contact with a ca-MRSA positive person and a predisposing skin lesion. Both cases underpin the role of ca-MRSA transmission and the potential severeness of wound infections in young and immunocompetent persons, just to be resolved by invasive intervention.

Conclusions Marked and recalcitrant skin or soft tissue infections in otherwise healthy young patients require instant microbiological analysis and surgical intervention flanked by adequate antibiotic therapy. Contact dermatitis induced by plant toxins should be taken into consideration as possible risk factor for the acquisition of ca-MRSA.
Chronische spontane Urtikaria, Adipositas und metabolische Erkrankungen
Authors: Zarnowski Julia , Simon Jan-Christoph , Treudler Regina
Published: November 2022

Ziel Darstellung der aktuellen Literatur und neuer Erkenntnisse zum Zusammenhang der chronisch spontanen Urtikaria (CSU) mit Adipositas-assoziierter Inflammation und metabolischen Erkrankungen.

Methodik Eine englischsprachige, Pubmed-basierte Literaturrecherche mit den Stichwörtern „chronic urticaria“ und „hypertension“, „hyperlipidemia“, „metabolic syndrome“, „metabolic diseases“, „obesity“, „overweight“, „glucose intolerance“, „diabetes“ sowie zu „cytokines“, „pro-inflammatory“, „adipokines“, „immunological dysregulation“.

Ergebnisse In der aktuellen Literatur zeigen sich erhöhte Prävalenzen für Adipositas, Diabetes mellitus, Hyperlipidämie und Hypertonie bei CSU-Patienten. Zudem zeigen sich signifikante Assoziationen zwischen metabolischen Komorbiditäten und der klinischen Ausprägung, Krankheitsdauer oder dem therapeutischen Ansprechen bei der CSU. Darüber hinaus lassen sich gemeinsame immunologische Merkmale zwischen der CSU und Adipositas erkennen, da eine Dysbalance pro- und anti-inflammatorisch wirksamer Zytokine sowie Adipokine zugunsten eines pro-inflammatorischen Zustandes bei beiden Erkrankungen vorliegt. Die Ableitung klinischer Implikationen in Hinblick auf Screening-, Präventions- oder Interventionsmaßnahmen metabolischer Erkrankungen bei der CSU sollte diskutiert werden.
Malignes Melanom und Adipositas: eine
Übersichtsarbeit
Authors: Zidane Miriam , Theurich Sebastian , Schlaak Max
Published: November 2022

Einleitung Die Inzidenz von Adipositas nimmt weltweit stetig zu.
Übergewicht und Adipositas werden als mögliche Risikofaktoren
für verschiedene Krebserkrankungen, einschließlich des malignen
Melanoms, diskutiert. Dieser Review stellt die Evidenz zu der Assoziation
zwischen Adipositas und dem malignen Melanom dar.

Methodik Selektive Literaturrecherche.

Ergebnisse Obwohl verschiedene Erklärungsansätze
für eine mögliche Assoziation von Adipositas und dem malignen
Melanom existieren, sind diese nicht vollständig bekannt und weiterhin
Gegenstand der Forschung. Die Evidenz zur Assoziation zwischen Adipositas und
Melanom-Outcomes für Patienten ohne Systemtherapie ist gering.
Für Patienten mit Systemtherapie gibt es Evidenz, die einen protektiven
Effekt unter Immuntherapien und zielgerichteten Therapien beschreibt.

Schlussfolgerung Insgesamt gibt es zu der Assoziation zwischen dem
malignen Melanom und Adipositas nicht ausreichend Evidenz, um zu schlussfolgern,
ob Adipositas einen unabhängigen protektiven Effekt hat oder ein
Risikofaktor für die Entstehung von Melanomen darstellt. Weitere
Forschung ist erforderlich, um das Wissen über diesen möglichen
Zusammenhang zu vertiefen.
Digitale Gesundheitsinterventionen entwickeln, evaluieren und
implementieren Teil II – Diskussionspapier der Arbeitsgruppe Digital
Health des Deutschen Netzwerk Versorgungsforschung (DNVF)
Authors: Kernebeck Sven , Scheibe Madlen , Sinha Monika , Fischer Florian , Knapp Andreas , Timpel Patrick , Harst Lorenz , Reininghaus Ulrich , Vollmar Horst Christian
Published: November 2022

Methodische Herausforderungen bei der Evaluation digitaler Interventionen (DI)
sind für die Versorgungsforschung allgegenwärtig. Die
Arbeitsgruppe Digital Health des Deutschen Netzwerks Versorgungsforschung (DNVF)
hat in einem zweiteiligen Diskussionspapier diese Herausforderungen dargestellt
und diskutiert. Im ersten Teil wurden begriffliche Abgrenzungen sowie die
Entwicklung und Evaluation von DI thematisiert. In diesem zweiten Teil wird auf
Outcomes, das Reporting von Ergebnissen, die Synthese der Evidenz sowie die
Implementierung von DI eingegangen. Lösungsansätze und
zukünftige Forschungsbedarfe zur Adressierung dieser Herausforderungen
werden diskutiert.
Subclavian Effort and Upper Limb Thrombosis – a Lesson Learned
Authors: Krasiński Zbigniew , Pukacki Piotr , Begier-Krasinska Beata
Published: November 2022

Subclavian vein effort and upper limb thrombosis, known as the Paget-Schroetter syndrome (PSS), accounts for 30–40 % of spontaneous upper extremity deep vein thromboses (UEDVTs) and 10–20 % of all upper limb deep vein thromboses (DVTs). As complication of PSS include post-thrombotic syndrome and pulmonary embolism, early recognition and prompt initiation of anticoagulant treatment is crucial in the course of its treatment. PSS is associated with single or repeated physical activity of the upper limb, combined with obstruction of venous outflow resulting from anatomical alterations. A correct diagnosis, based on a range of imaging methods, and prompt initiation of local thrombolytic therapy, surgical decompression of the thoracic outlet (when necessary), and immediate initiation of anticoagulant treatment, aim to effectively restore the patient life quality, preventing post-thrombotic syndrome and recurrent thrombosis.
VEP W-Form, Wie kommt es dazu? Was tun damit?
Authors: Paulus Walter
Published: November 2022

Seit mehr als 50 Jahren hat die Ableitung visuell evozierter Potentiale (VEP) einen
festen Stellenwert in der klinischen neurophysiologischen Diagnostik. Die Komponente
P100 nach Schachbrettmusterreizung hat sich in der Praxis als besonders robust und
aussagekräftig herausgestellt. Das VEP bietet als Ergänzung zur
strukturellen Bildgebung (MRT; optische Kohärenztomographie der Netzhaut)
die Möglichkeit, auch Leitungsverzögerungen und damit
Demyelinisierungen der Sehnerven zu belegen. Im Idealfall verschiebt sich
z. B. bei Neuritis nervi optici die typische und klare NPN-Konstellation mit
Negativität bei etwa 70 ms, Positivität bei 100 ms und weiterer
Negativität um 130 ms in ihrer Gesamtheit zu höheren Latenzzeiten
(Abb. 1).
Ischiadikusläsion nach Ruptur der ischiokruralen Muskulatur:
Trauma, Op-Komplikation oder Druckschädigung?
Authors: Müngerdorf Martina
Published: November 2022

Die 61jährige begeisterte Bergwanderin stellte sich 4 Wochen nach einem
Trauma vor. Die sportliche Frau war beim Skilanglauf nach vorne gekippt, das linke
Bein war dabei vollständig gestreckt. Dabei ist es zu einer
plötzlichen heftigen Dehnung der ischiokruralen Muskulatur links
gekommen.
Liebe Leserinnen und Leser,
Authors: Buchner Helmut
Published: November 2022

Liebe Leserinnen und Leser,

das Jahr neigt sich dem Ende zu. Wie war das Jahr?

Zu den Erschütterungen der Pandemie und der Flutkatastrophe, nun der Krieg in
der Ukraine mit all dem Leid und den sozio-ökonomischen, geopolitischen
Folgen.
Potential Benefit of Probiotic E. Coli Nissle in Term Neonates
Authors: Olbertz Dirk , Proquitté Hans , Patzer Ludwig , Erler Thomas , Mikolajczak Alexsandra , Sadowska-Krawczenko Iwona , Wolff Corinna , Radke Michael
Published: November 2022

Background Probiotics are often viewed as an immunity enhancing
agent. The objective of this study was to investigate whether oral
administration of Escherichia coli Nissle 1917 reduces the number of infections,
their duration, and severity in the first 24 months after parturition in healthy
neonates.

Subjects and methods This prospective, confirmatory,
randomised, double-blind, placebo-controlled study enrolled 567 healthy neonates
from four German and two Polish sites. Neonates received 10e8 viable E. coli
Nissle (n=283) or placebo (n=284) daily in the first week and
every second day in week 2 and 3. After 6 and 12 months, the subjects received
additional instillations on ten subsequent days. The overall efficacy was
assessed by the number of infections per observation
period.

Results Incidence rates of infection, infection duration
and severity showed no statistically significant difference between groups after
24 months. Post-hoc analyses, however, revealed a short-term benefit of E. coli
Nissle four weeks after treatment start which became less pronounced after eight
weeks. E. coli Nissle was safe and well tolerated.

Conclusions A
long-term effect after colonising the healthy neonate´s gut with E. coli
Nissle to protect against infections could not be shown. Additional studies are
needed to confirm a transitory, yet clinically significant role of probiotics in
the first four weeks after parturition.
Transition-Metal-Free β-Selective C-Glycosylation of β-Glycosyl Boronates via Stereoretentive 1,2-Migration
Authors: Yoritate Makoto , Hirai Go , Yasutomi Hiroki , Takeda Daiki , Higashibayashi Shuhei , Sugai Takeshi
Published: November 2022

C-Glycoside analogues of native glycans are useful molecular tools for medicinal chemistry and chemical biology due to their resistance to cellular glycoside hydrolases. We previously reported an α-selective direct C-glycosylation of 2-deoxy-β-glycosyl boronate through a Ni/photoredox-catalyzed stereoinvertive cross-coupling reaction. Here we report a complementary stereoretentive synthetic method for the preparation of β-C-glycosides from a similar boronate precursor through the addition of a C(sp2) anion followed by 1,2-migration of the glycosyl donor.
Elective and Emergent Surgery in the Ulcerative Colitis Patient
Authors: DeLeon Michelle F. , Stocchi Luca
Published: November 2022

Ulcerative colitis (UC) requires surgical management in 20 to 30% of patients. Indications for surgery include medically refractory disease, dysplasia, cancer, and other complications of UC. Appropriate patient selection for timing and staging of surgery is paramount for optimal outcomes. Restorative proctocolectomy is the preferred standard of care and can afford many patients with excellent quality of life. There have been significant shifts in the treatment of UC-associated dysplasia, with less patients requiring surgery and more entering surveillance programs. There is ongoing controversy surrounding the management of UC-associated colorectal cancer and the techniques that should be used. This article reviews the most recent literature on the indications for elective and emergent surgical intervention for UC and the considerations behind the surgical options.
The Safety and Efficacy of Preoperative Immunotherapy Combined with Chemotherapy in Patients with Stage IIIA-IIIB Lung Squamous Cell Carcinoma
Authors: Wang Ying , He Cheng , Liu Jiacong , Wu Simeng , Huang Xuhua , Zhang Lichen , Shu Wenbo , Gu Chen , Wang Yiqing , Zhu Linhai , Hu Jian
Published: November 2022

Objective Data on preoperative immunotherapy combined with chemotherapy in potentially resectable lung squamous cell carcinoma (LUSC) remain scarce. This study was designed to investigate the safety and efficacy of preoperative immunotherapy and chemotherapy for stage IIIA-IIIB LUSC.

Methods This study consecutively enrolled stage IIIA-IIIB LUSC who received preoperative immunotherapy combined with chemotherapy between January 2019 and July 2021. Patients received two to four cycles of immunotherapy combined with platinum-based doublet chemotherapy (platinum + paclitaxel) before surgery. Patients were assessed radiographically every one to two cycles until surgery. Postoperative pathological evaluation was also performed. Follow-up was performed until at least 3 months after surgery.

Results Sixty-five patients with stage IIIA-IIIB LUSC were enrolled. The objective response rate was 78.46% (51/65), and no patients had progressive disease. Fifty-seven patients underwent surgery, and 55 patients achieved R0 resection. There were no perioperative deaths. The rate of pathological complete response (pCR) was 31.58% (18/57) and major pathological response was 68.42% (39/57). The incidence of grade 3 and 4 adverse reactions was 21.21 and 1.54%, respectively.

Conclusion Perioperative immunotherapy combined with chemotherapy followed by surgical resection for male patients with stage IIIA-IIIB LUSC was effective with a tolerable toxicity profile.
Austauschmöglichkeit: Jahresveranstaltung Sana Dialog 2022
Authors: Salein Tobias
Published: November 2022

Nach zweijähriger Unterbrechung war es die erste große Präsenzveranstaltung der Einkaufskooperation: Am 19. September kamen 400 Teilnehmerinnen und Teilnehmer – aus Kliniken, Klinikeinkauf, Logistik, aus Industrie, Politik und Verbänden – in Berlin zusammen zum „Sana Dialog 2022 – Endlich!“, der Jahresveranstaltung von Sana Einkauf & Logistik.
OLG Frankfurt: Vergabe öffentlicher Aufträge unter Termindruck – Was ist das richtige Verfahren?
Authors: Antweiler Clemens
Published: November 2022

Bei der Vergabe öffentlicher Aufträge stehen Krankenhäuser regelmäßig unter hohem Termindruck. Auf den ersten Blick scheint dann ein Verhandlungsverfahren ohne Teilnahmewettbewerb in Betracht zu kommen. Die Voraussetzungen dafür sind aber sehr hoch. Besser ist es deshalb, öffentliche Aufträge im offenen oder im nicht offenen Verfahren zu vergeben und dabei die Fristen auf das zulässige Minimum zu verkürzen. Das ist die Folge eines Beschlusses des Oberlandesgerichts Frankfurt.
Improving spacecraft payload system performance through low-pressure discharge process
Authors: McConnon Aili
Published: November 2022

3D model simulates low-pressure discharge in microwave circuits to clarify the relevant transformation between secondary and ionized electrons that impact spacecraft microwave loads
Comparative heat transfer analysis of electroconductive Fe3O4–MWCNT– water and Fe3O4–MWCNT– kerosene hybrid nanofluids in a square porous cavity using the non-Fourier heat flux model
Authors: Thirumalaisamy K. , Ramachandran Sivaraj , Ramachandra Prasad V. , Anwar Bég O. , Leung Ho-Hon , Kamalov Firuz , Panneer Selvam R.
Published: November 2022

The analysis of heat transmission and fluid flow characteristics within the cavity is useful to improve the features of several applications including energy storage devices and hybrid fuel cells. With this motivation, the present model investigates the characteristics of magneto-convective heat transmission and fluid flow within a square porous enclosure with hot and cold slits. The heat transfer features of electrically conducting hybrid nanofluids Fe3O4–MWCNT– water and Fe3O4–MWCNT– kerosene are analyzed inside the enclosure. The non-Fourier thermal flux model is deployed, and the internal heat absorption/generation effect is considered. The marker-and-cell numerical scheme is adopted to solve the transformed dimensionless mathematical model with associated initial–boundary conditions. An exhaustive parametric investigation is implemented to estimate the influence of key parameters on transport phenomena. The computations show that augmenting the Hartmann number values modifies the fluid flow and temperature features substantially for both hybrid nanofluids. Enhancing the values of nanoparticles volume fraction promotes the heat transfer. When 5% Fe3O4–MWCNT nanoparticles are suspended into water and kerosene base fluids, Fe3O4–MWCNT– kerosene hybrid nanofluid achieves 6.85% higher mean heat transfer rate compared to Fe3O4–MWCNT– water hybrid nanoliquid. In the existence of heat absorption, the mean rate of heat transfer of Fe3O4–MWCNT– water hybrid nanofluid is 78.92% lower than Fe3O4–MWCNT– kerosene hybrid nanoliquid. Greater energy transmission is noticed in the case of Fe3O4–MWCNT– kerosene hybrid nanofluid, and the enhanced fluid flow is noticed in the case of Fe3O4–MWCNT– water hybrid nanofluid. Fourier's model (δe=0) estimates higher heat transfer rate than that of the Cattaneo–Christov (non-Fourier) heat flux model (δe≠0).
Study of phase equilibria and thermodynamic properties of liquid mixtures using the integral equation theory: Application to water and alcohol mixtures
Authors: Yamaguchi Tsuyoshi , Chong Song-Ho , Yoshida Norio
Published: November 2022

A theoretical method for calculating the thermodynamic properties and phase equilibria of liquid–liquid mixtures using the integral equation theory is proposed. The solvation chemical potentials of the two components are evaluated by the integral equation theory and the isothermal–isobaric variation of the total density with composition is determined to satisfy the Gibbs–Duhem relation. Given the density of a pure component, the method can calculate the densities of the mixture at any composition. Furthermore, it can treat the phase equilibrium without thermodynamic inconsistency with respect to the Gibbs–Duhem relation. This method was combined with the reference interaction-site model integral equation theory and applied to mixtures of water + 1-alcohol by changing the alcohol from methanol to 1-butanol. The destabilization of the mixing Gibbs energy by increasing the hydrophobicity of the alcohol and demixing of the water–butanol mixture were reproduced. However, quantitative agreement with experiments is not satisfactory, and further improvements of the integral equation theory and the molecular models are required.
High-throughput functional annotation of natural products by integrated activity profiling
Authors: Hight Suzie K. , Clark Trevor N. , Kurita Kenji L. , McMillan Elizabeth A. , Bray Walter , Shaikh Anam F. , Khadilkar Aswad , Haeckl F. P. Jake , Carnevale-Neto Fausto , La Scott , Lohith Akshar , Vaden Rachel M. , Lee Jeon , Wei Shuguang , Lokey R. Scott , White Michael A. , Linington Roger G. , MacMillan John B.
Published: November 2022

Determining mechanism of action (MOA) is one of the biggest challenges in natural products discovery. Here, we report a comprehensive platform that uses Similarity Network Fusion (SNF) to improve MOA predictions by integrating data from the cytological profiling high-content imaging platform and the gene expression platform Functional Signature Ontology, and pairs these data with untargeted metabolomics analysis for de novo bioactive compound discovery. The predictive value of the integrative approach was assessed using a library of target-annotated small molecules as benchmarks. Using Kolmogorov–Smirnov (KS) tests to compare in-class to out-of-class similarity, we found that SNF retains the ability to identify significant in-class similarity across a diverse set of target classes, and could find target classes not detectable in either platform alone. This confirmed that integration of expression-based and image-based phenotypes can accurately report on MOA. Furthermore, we integrated untargeted metabolomics of complex natural product fractions with the SNF network to map biological signatures to specific metabolites. Three examples are presented where SNF coupled with metabolomics was used to directly functionally characterize natural products and accelerate identification of bioactive metabolites, including the discovery of the azoxy-containing biaryl compounds parkamycins A and B. Our results support SNF integration of multiple phenotypic screening approaches along with untargeted metabolomics as a powerful approach for advancing natural products drug discovery.
Inflammatory response to retrotransposons drives tumor drug resistance that can be prevented by reverse transcriptase inhibitors
Authors: Novototskaya-Vlasova Ksenia A. , Neznanov Nickolay S. , Molodtsov Ivan , Hall Brandon M. , Commane Mairead , Gleiberman Anatoli S. , Murray Jayne , Haber Michelle , Norris Murray D. , Leonova Katerina I. , Gudkov Andrei V.
Published: November 2022

Activation of endogenous retrotransposons frequently occurs in cancer cells and contributes to tumor genomic instability. To test whether inhibition of retrotranspositions has an anticancer effect, we used treatment with the nucleoside reverse transcriptase inhibitor (NRTI) stavudine (STV) in mouse cancer models, MMTV-HER2/Neu and Th-MYCN, that spontaneously develop breast cancer and neuroblastoma, respectively. In both cases, STV in drinking water did not affect tumor incidence nor demonstrate direct antitumor effects. However, STV dramatically extended progression-free survival in both models following an initial complete response to chemotherapy. To approach the mechanism underlying this phenomenon, we analyzed the effect of NRTI on the selection of treatment-resistant variants in tumor cells in culture. Cultivation of mouse breast carcinoma 4T1 in the presence of STV dramatically reduced the frequency of cells capable of surviving treatment with anticancer drugs. Global transcriptome analysis demonstrated that the acquisition of drug resistance by 4T1 cells was accompanied by an increase in the constitutive activity of interferon type I and NF-κB pathways and an elevated expression of LINE-1 elements, which are known to induce inflammatory responses via their products of reverse transcription. Treatment with NRTI reduced NF-κB activity and reverted drug resistance. Furthermore, the inducible expression of LINE-1 stimulated inflammatory response and increased the frequency of drug-resistant variants in a tumor cell population. These results indicate a mechanism by which retrotransposon desilencing can stimulate tumor cell survival during treatment and suggest reverse transcriptase inhibition as a potential therapeutic approach for targeting the development of drug-resistant cancers.
Convergence rate analysis of Galerkin approximation of inverse potential problem
Authors: Jin Bangti , Lu Xiliang , Quan Qimeng , Zhou Zhi
Published: November 2022

In this work we analyze the inverse problem of recovering a space-dependent potential coefficient in an elliptic / parabolic problem from distributed observation. We establish novel (weighted) conditional stability estimates under very mild conditions on the problem data. Then we provide an error analysis of a standard reconstruction scheme based on the standard output least-squares formulation with Tikhonov regularization (by an H
1-seminorm penalty), which is then discretized by the Galerkin finite element method with continuous piecewise linear finite elements in space (and also backward Euler method in time for parabolic problems). We present a detailed error analysis of the discrete scheme, and provide convergence rates in a weighted

L
2

(
Ω
)

for discrete approximations with respect to the exact potential. The error bounds explicitly depend on the noise level, regularization parameter and discretization parameter(s). Under suitable conditions, we also derive error estimates in the standard

L
2

(
Ω
)

and interior L
2 norms. The analysis employs sharp a priori error estimates and nonstandard test functions. Several numerical experiments are given to complement the theoretical analysis.
Surface recombination velocities for the (100) and (001) crystal faces of bismuth vanadate single crystals
Authors: Zhang Endong , Kato Masashi
Published: November 2022

Bismuth vanadate (BiVO4) is widely used as a photocatalyst for water splitting, and its carrier lifetime is the most essential parameter for photocatalysts. In this study, we characterized the carrier lifetime in BiVO4 single crystals on the (100) and (001) crystal faces using the microwave photoconductivity decay (μ-PCD) method. For the (001) face, the observed μ-PCD curves with excitation by a 266 nm laser had no injected photon density dependence. In contrast, those excited using a 355 nm laser had an injected photon density dependence. The decay at a high injected photon density was faster than that at a low injected photon density. For the (100) face, the decay curves at both excitations of 266 and 355 nm were not significantly different, and they depended on the injected photon density. These results indicate that the carrier lifetime is dominated by surface recombination only under the 266 nm excitation condition for the (001) face, whereas under other conditions, this is dominated by the Schokley–Read–Hall recombination. The temperature independence of the μ-PCD curves indicates that the recombination center is sufficiently deep in the bandgap. We estimated the surface recombination velocities and bulk lifetimes of the samples by fitting the experimental results to the calculations. We believe that the estimated surface recombination velocity and bulk lifetime will aid in the design of BiVO4 photocatalysts.
Conductance anisotropy of MOCVD-grown α-Ga2O3 films caused by (010) β-Ga2O3 filament-shaped inclusions
Authors: Egyenes F , Gucmann F , Rosová A , Dobročka E , Hušeková K , Hrubišák F , Keshtkar J , Ťapajna M
Published: November 2022

A significant anisotropy in the electrical conductance was observed in Si-doped α-Ga2O3/sapphire samples grown via liquid-injection metal organic chemical vapor deposition. Additionally to epitaxial α-Ga2O3 diffraction, x-ray diffraction (XRD) revealed maxima related to (010) β-Ga2O3. Transmission electron microscopy, atomic force microscopy (AFM), and Raman spectroscopy of undoped samples with similar XRD pattern confirmed the formation of (010) β-Ga2O3 filaments in the epitaxial α-Ga2O3 film. In Si-doped samples, conductive AFM and temperature-dependent current–voltage measurement on transmission line measurement resistors confirmed, that β-Ga2O3 filaments were responsible for significantly higher conductivity along the

2

1
ˉ

1
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0

 

α-Ga2O3 direction compared to [0001] α-Ga2O3 direction. Current–voltage measurements of transistor structures suggested semiconducting behavior of the β-Ga2O3 filaments embedded in the highly resistive α-Ga2O3 films.
Effective potentials in a rotating spin-orbit-coupled spin-1 spinor condensate
Authors: Banger Paramjeet , Kumar R Kishor , Roy Arko , Gautam Sandeep
Published: November 2022

We theoretically study the stationary-state vortex lattice configurations of rotating spin-orbit (SO)- and coherently-coupled spin-1 Bose–Einstein condensates (BECs) trapped in quasi-two-dimensional harmonic potentials. The combined effects of rotation, SO and coherent couplings are analyzed systematically from the single-particle perspective. Through the single-particle Hamiltonian, which is exactly solvable for one-dimensional coupling, we illustrate that a boson in these rotating SO- and coherently-coupled condensates are subjected to effective toroidal, symmetric double-well, or asymmetric double-well potentials under specific coupling and rotation strengths. In the presence of mean-field interactions, using the coupled Gross–Pitaevskii formalism at moderate to high rotation frequencies, the analytically obtained effective potential minima and the numerically obtained coarse-grained density maxima position are in excellent agreement. On rapid rotation, we further find that the spin-expectation per particle of an antiferromagnetic spin-1 BEC approaches unity indicating a similarity in the response with ferromagnetic SO-coupled condensates.
Multiple fault diagnosis for rolling bearings method employing CEEMD-GCN based on horizontal visibility graph
Authors: Xiaoyun Gong , Kunpeng Feng , Zeheng Zhi , Yiyuan Gao , Wenliao Du
Published: November 2022

Multiple faults often occur in the operation of rotating machinery transmission systems. The fault signals of multiple bearings interfere with each other, which makes feature extraction and diagnosis of complex compound fault signals difficult. Because the graph convolution networks (GCN) can effectively map the structural information from complex data and its model has a certain generalization ability, this paper proposes a multiple fault diagnosis method for rolling bearings employing complete ensemble empirical mode decomposition (CEEMD) and a GCN (CEEMD-GCN) based on a horizontal visibility graph (HVG). Firstly, in order to highlight the effective feature information in the multiple fault signal and reduce noise interference, multiple indicators of correlation and kurtosis are used to reconstruct the decomposed signals through CEEMD; secondly, the reconstructed signals are constructed as an HVG, and the HVG maps the time series signal to the graphic structure data, reflecting the local geometric characteristics of the vibration signal through the horizontal visibility relationship; finally, taking the signal samples obtained by the HVG algorithm as the input data of the model, the GCN model is trained to realize the diagnosis of multiple faults. The experimental results show that the presented methodology is superior to other methods and exhibits generalization ability for multiple fault diagnosis.
Binocular visual dimension measurement method for rectangular workpiece with a precise stereoscopic matching algorithm
Authors: Chen Lin , Zhong Guowei , Han Ze , Li Quanwen , Wang Yijue , Pan Haihong
Published: November 2022

Binocular vision measurement benefits from high prediction robustness and low structural complexity. However, there are still significant flaws in its accuracy. In this paper, binocular vision measurement of a rectangular workpiece is investigated. A new precise measurement method based on binocular vision is designed to achieve precise measurement of rectangular workpiece dimensions. Firstly, an algorithm for workpiece location based on Zernike moments and corner matching is proposed and employed to precisely locate the workpiece and extract the sub-pixel coordinates of discrete points on an image’s edge. Then, a novel stereoscopic matching algorithm combined with epipolar-geometry and cross-ratio invariance (CMEC) is proposed to improve the accuracy of binocular vision stereoscopic matching. Finally, a projection plane is introduced after the 3D reconstruction of discrete points in the workpiece contours by fitting the plane with least squares. The projection plane limits the coordinate fluctuations of discrete points. Furthermore, the data screening is used to further improve the accuracy of size calculation. The experimental results of the standard checkerboard and actual workpiece show that CMEC’s matching accuracy reached 99%, and the proposed method’s measurement accuracy reached 0.018 mm. This work presents a novel algorithm for stereoscopic matching in binocular vision and machine vision measurement.