bluuebunny/crossref_metadata_2025 huggingface dataset:
Publishing the Data from “The Effects of Communication Mode and Culture on Deception Detection Accuracy”
Authors: George Joey F. , Gupta Manjul , Giordano Gabriel , Mills Annette , Tennant Vanesa , Lewis Carmen
Published: June 2023

With the publication of this article, we are making available the dataset collected for and analyzed in our 2018 MIS Quarterly article “The Effects of Communication Mode and Culture on Deception Detection Accuracy.” Our article examined the relationships between computer-based modes of communication and national culture on deception detection success. We provide additional information about the dataset and how it was collected, as well as suggestions for future research. This additional information should help any scholar interested in further analysis of the dataset or extending our study.
Voluntary Performance Disclosures in the CD&A
Authors: Packard Heidi A. , Pawliczek Andrea , Skinner A. Nicole
Published: June 2023

This paper examines voluntary disclosure in the context of shareholder scrutiny of executive compensation contracts. We find that firms voluntarily increase discussion of their performance within their CD&A disclosures when peer-benchmarked compensation relative to performance is high. In contrast, we do not find a similar increase in performance discussion in the corresponding MD&A disclosures, which suggests that the effect is not driven by firms’ general disclosure practices. We also find that the relation between relatively high compensation and CD&A performance disclosure strengthens following the implementation of mandatory Say-on-Pay, which increased costs associated with investor criticism of pay. These disclosures appear to be used effectively to avoid negative compensation assessments, in that they are associated with higher levels of shareholder and proxy advisor approval. Altogether, our findings suggest that CD&A performance disclosures allow firms to communicate the context of their compensation choices to improve shareholder opinions of pay.

Data Availability: Data are available from the public sources cited in the text.

JEL Classifications: D22; J33; M41.
Why Some Investors Avoid Accounting Information: Identifying a Psychological Cost of Information Acquisition Using the Securities-Based Crowdfunding Setting
Authors: Cade Nicole L. , Garavaglia Shannon M. , Hoffman Vicky B.
Published: June 2023

We conduct an experiment in the securities-based crowdfunding setting to investigate whether some investors avoid accounting information for psychological reasons, even when they understand the information is useful in their decision-making. Results suggest investors who experience relatively more psychological discomfort when working with quantitative information are relatively less likely to acquire the financial statements of a potential crowdfunding investment. Importantly, this effect is incremental to any effect of investors' quantitative ability (i.e., their numeracy) and attenuates with an intervention designed to help investors overcome their psychological discomfort. Altogether, the results extend our understanding of the theory of information avoidance, provide a behavioral explanation for investors' documented underuse of accounting information, and can inform regulators as they revise crowdfunding regulations.

JEL Classifications: G11; G41; M41.
Characteristics of Café-au-lait Macules and their Association with the Neurofibromatosis type I Genotype in a Cohort of Greek Children
Authors: Nasi Lamprini , Alexopoulos Alexios , Kokkinou Eleftheria , Roka Kleoniki , Tzetis Maria , Tsipi Maria , Kakourou Talia , Kanaka-Gantenbein Christina , Chrousos George , Kattamis Antonis , Pons Roser
Published: June 2023

Cafe-au-lait macules are the most distinctive clinical finding in neurofibromatosis type I. The aim of this prospective study of Greek children diagnosed with neurofibromatosis type I was to describe the dermatological phenotype and to analyse the characteristics of cafe-au-lait macules and their association with genotype. Pigment intensity and melatonin content of cafe-au-lait macules were measured with a narrowband spectrophotometer. A total of 63 children aged 6 months to 16 years old were studied. Mean melanin content varied, both among patients, and within each patient (p < 0.001). Females had a higher number of cafe-au-lait macules than did males (p = 0.025), and the melanin content of cafe-au-lait macules was lower in females than males (p < 0.001). Patients with protein-truncating variants in the neurofibromatosis type I gene had higher melanin content of cafe-au-lait macules than other types of genetic variants t (55) = 2.196, p = 0.032. Plexiform neurofibromas were also detected in the majority of patients with protein- truncating variants, while juvenile xanthogranulomas were detected equally in patients with protein-truncating and non-protein-truncating variants. In conclusion, cafe-au-lait macules with high melatonin content are associated with patients carrying non-protein-truncating variants. Therefore, measurement of cafe-au-lait macule pigment intensity might provide useful information for initial assessment of patients with neurofibromatosis type I and the severity of their future phenotype.
Mind Set dan Sikap Ilmiah dan Pengaruhnya terhadap Kemampuan Literasi Sains Siswa Kelas V Sekolah Dasar
Authors: Saputra I Nyoman Adi , Gading I Ketut , Aisyah Siti
Published: June 2023

Sebagian besar siswa masih mengalami kesulitan dalam mengembangkan kemampuan berfikir menggunakan penalaran, belum memiliki kebiasaan membaca sambil berpikir dan bekerja untuk memahami informasi esensial atau strategis dalam menyelesaikan soal atau permasalahan. Penelitian ini bertujuan untuk menganalisis pola pikir (mind set) dan sikap ilmiah terhadap kemampuan literasi sains siswa kelas V Sekolah Dasar. Jenis penelitian adalah jenis Expose facto. Populasi dalam penelitian ini sebanyak 428 orang siswa. Sampel penelitian berjumlah 171 siswa yang ditentukan dengan teknik random sampling. Metode pengumpulan data menggunakan kuesioner. Data dianalisis menggunakan uji korelasi product moment, dan uji F Regresi. Hasil penelitian menunjukkan bahwa: terdapat kontribusi negatif pola pikir tetap terhadap kemampuan literasi sains siswa yang ditunjukkan dengan nilai korelasi sebesar -0,820, hal ini dapat diartikan bahwa pola pikir tetap berbanding terbalik terhadap kemampuan literasi sains siswa. Secara simultan, terdapat kontribusi pola pikir berkembang dan sikap ilmiah terhadap kemampuan literasi sains siswa, dengan hasil F hitung sama dengan 389,396 dengan signifikansi 0,000 kurang dari 0,05. Disimpulkan bahwa terdapat kontribusi pola pikir dan sikap ilmiah terhadap kemampuan literasi sains siswa. Implikasi penelitian ini dharapkan guru dalam meningkatkan kemampuan literasi sains siswa hendaknya juga mempertimbangkan factor internal yang dimiliki oleh siswa berupa pola pikir dan sikap ilmiah.
Model Children Learning in Science Berbasis Masalah Kontekstual terhadap Motivasi dan Hasil Belajar IPA Siswa Kelas V Sekolah Dasar
Authors: Mulyadinata I Putu Lagas , Ardana I Made , Candiasa I Made
Published: June 2023

Hasil belajar IPA pada sekolah dasar masih rendah dikarenakan cara belajar siswa yang masih kurang efektif dalam meningkatkan kemampuan siswa sehingga perlunya penerapan model pembelajaran yang bagus. Penelitian bertujuan untuk mengetahui pengaruh model Children Learning in Science berbasis masalah kontekstual terhadap motivasi dan hasil belajar IPA siswa kelas V SD. Penelitian ini adalah penelitian eksperimen semu (Quasi Eksperimen) dengan rancangan Pretest Posttest Control Group Design. Populasi penelitian adalah seluruh siswa Kelas V SD yang terdiri dari 309 orang siswa. Sebanyak 63 siswa dipilih sebagai sampel yang ditentukan dengan teknik random sampling. Data hasil belajar dikumpulkan menggunakan metode tes objektif pilihan ganda sedangkan data motivasi belajar dikumpulkan menggunakan metode non tes berupa kuisioner. Data dianalisis dengan menggunakan analisis MANOVA dan Anava dengan hasil Penelitian menunjukkan bahwa model pembelajaran Children Learning in Science berbasis masalah kontekstual berpengaruh positif terhadap motivasi dan hasil belajar IPA siswa kelas V SD, baik secara simultan maupun secara terpisah. Implikasi dari penelitian ini adalah pentingnya menggunakan pendekatan pembelajaran yang mempertimbangkan konteks dan masalah nyata dalam mengajar IPA di sekolah dasar.
Penggunaan Media Pembelajaran Powtoon Untuk Meningkatkan Minat dan Hasil Belajar Peserta Didik Pada Mata Pelajaran IPS
Authors: Lestari Ni Putu Ayu Diah , Sukadi  , Maryati Tuty , Sriartha I Putu
Published: June 2023

Penelitian ini merupakan penelitian tindakan kelas yang dilakukan dalam dua kali siklus tindakan pembelajaran yang bertujuan untuk meningkatkan hasil dan minat belajar siswa dalam pembelajaran IPS yang masih rendah di kelas VII menggunakan media pembelajaran Powtoon. Penelitian ini menggunakan pendekatan deskriptif kualitatif dengan teknik pengumpulan data melalui beberapa metode yakni metode tes, observasi, dan metode wawancara. Berdasarkan penelitian ini maka ditemukan hasil. Pertama, penggunaan media pembelajaran Powtoon pada pembelajaran IPS di kelas VII dapat meningkatkan hasil dan minat belajar siswa. Kedua, kesulitan utama guru dalam penggunaan media pembelajaran Powtoon pada pembelajaran IPS di kelas VII, yaitu masalah tingkat perkembangan anak yang belum terbiasa diajak untuk memanfaatkan aplikasi pada laptop/gadged dalam pembelajaran. Ketiga, usaha-usaha yang dilakukan guru untuk mengatasi kesulitan tersebut adalah menyederhanakan materi pembelajaran agar waktu belajar siswa bisa lebih banyak dan siswa lebih fokus dengan materi diskusi. Implikasi dari hasil penelitian ini adalah guru IPS perlu menguatkan penggunaan media Powtoon dalam pembelajaran.
Process design and simulation study of an electricity generation plant utilizing low-grade wasted thermal energy using aspen Hysys software
Authors: Simanjuntak Janter Pangaduan , Pakpahan Binsar Maruli Tua , Purwantono Purwantono , Al-attab Khaled Ali
Published: June 2023

An analysis of the operational parameters of a small-scale electrical generation facility that uses the thermal energy contained in the flue gases from rubbish waste incineration is the goal of this study. To assess this system, the organic Rankine cycle (ORC) thermodynamic system was used. Since the organic fluid has a lower boiling point than water and can be evaporated with less thermal energy, it was chosen as a heat transfer medium instead of water. Aspen Hysys was utilized as a simulation tool, while R11 was used as the working fluid. To maximize the amount of available electrical output power, the plant's operational temperature, working fluid flow rate, and pressure are all maximized. According to the simulation's findings, flue gas may generate electric power between the ranges of 3.12 – 29.71 kW at working pressures between 2.5 and 3.5 bar and working fluid flow rates between 3.600 and 7200 kg/h when the temperature is between 50 and 95 oC. The system reaches a thermal efficiency of about 8.30 at 350 kPa of working fluid pressure.
Self-Concept of Adolescent Girls with Toxic Parents
Authors: Winanda Rezky , Rifani Rohmah , Siswanti Dian Novita
Published: June 2023

Toxic parental behavior has various negative impacts on adolescents in the identity search phase. This study focuses on knowing the form of negative behavior that adolescents get from toxic parents, self-concept, and the meaning of parent-child relationships for adolescents. This study uses a qualitative method using phenomenological interpretive analysis. The research respondents were women aged 19 and 21 years who lived with their parents as many as three people—data collection techniques using questionnaires and semi-structured interviews. The results of data analysis showed that there were six forms of toxic parental behavior obtained by adolescents girls: neglect, physical and verbal violence, anger venting, controlling, and differences in treatment with siblings. Harmful parental behavior has an impact on adolescent girls self-concept. The formed self-concept is positive and negative. Positive self-concept based on self-knowledge and self-expectations of adolescents. Self-concept based on adolescent negative self-assessment.. Adolescent girls interpret the relationship between parents and children with views about parents, family, and and the concept of ideal parent-child relationship.
Editorial Preface
Authors: Nurdin Nurdin
Published: June 2023

This issue (Vol. 17 issues 2) of Hunafa: Jurnal Studia Islamika offers eight articles covering topics of Islamic studies. Various issues relating to Islamic studies are interestingly presented to contribute to the body of knowledge and practices. Academia and practitioners in Islamic studies may gain insight from reading these articles.
Bringing Modern Russian Literature to Life: an Innovative Textbook Using Content and Language Integrated Learning for Students of Russian as a Foreign Language
Authors: Pronicheva I. A.
Published: June 2023

The article outlines an innovative approach to teaching modern Russian literature to international learners studying Russian as a foreign language. The method is based on Content and Language Integrated Learning (CLIL), a widely recognized approach to teaching various disciplines in foreign languages. By employing authentic materials and exercises, this approach helps learners to build their linguocultural competency while improving their language and speech competencies. The article proposes a well-structured students’ book that includes modern Russian writers’ texts, biographies, summaries, possible criticism of their works, and other authentic materials. The textbook is designed to be used for classwork and homework by students studying Russian as a foreign language at Philology departments. This approach has the potential to enhance learners’ understanding and appreciation of modern Russian literature while simultaneously improving their language skills.
PENDAPATAN ASLI DAERAH DIMASA PANDEMI COVID-19 (PADA KABUPATEN/KOTA se-JAWA TIMUR)
Authors: Sukma Erlinda Nurfatmi , . Norsain
Published: June 2023

Pajak daerah merupakan salah satu sumber penerimaan pendapatan asli daerah yang berkontribusi cukup besar. Sehingga penelitian ini bertujuan untuk menganalisis kontribusi pajak daerah terhadap pendapatan asli daerah di masa pandemi covid-19. Penelitian ini dilakukan pada Kabupaten/Kota se-Jawa Timur.

Metode pada penelitian ini menggunakan metode kuantitatif dan kualitatif,dimana peneliti menggunakan data realisasi anggaran tahun 2019 dan tahun 2020 serta hasil wawancara yang dikumpulkan melalui berita. Teknik analisis untuk metode kuantitatif menggunakan regresi linear sederhana dan uji wilcoxon, sedangkan metode kualitatif menggunakan reduksi data, penyajian data, dan verifikasi/penarikan kesimpulan.

Hasil dalam penelitian ini menunjukkan bahwa kontribusi pajak daerah di masa pandemi covid-19 tidak berpengaruh dan tidak tidak signifikan terhadap pendapatan asli daerah. Terdapat perbedaan antara kontribusi pajak daerah di masa pandemi dengan sebelum pandemi covid-19. Serta kondisi pajak daerah di masa pandemi lebih dominan meningkat dibandingkan yang menurun.
ATIVIDADES FÍSICAS NA PREVENÇÃO E CONTROLE DE DOENÇAS CARDIOVASCULARES EM IDOSOS
Authors: Botton Ana Luiza , Alquieri Carolina Zuffo , Moschetta Gabriela , Oro Ligia , Hanel Maria Eduarda , Miranda Maria Lúcia Furlanetto , Colpani Natascha Rubas , Passuello Raphaela , Lutinski Junir Antonio
Published: June 2023

O rápido crescimento dos indivíduos acima dos 60 anos tem demonstrado a necessidade e a importância de estudos a respeito do envelhecimento saudável. Avaliar a relação entre atividade física e prevenção ou controle de doenças cardiovasculares em idosos, buscando uma melhor compreensão com relação à temática abordada a fim de aprimorar a assistência à saúde do idoso. Trata-se de uma revisão integrativa da literatura. Foi realizada uma busca pelos artigos disponíveis nos idiomas português e inglês, nas bases de dados PUBMED e CAPES, publicados no período entre 2010 e 2021. Os dados foram explorados e os resultados apresentados através de figuras e tabelas construídas em Excel for Windows (.xlsx). Ao todo, um total de 12 artigos foram analisados. O “n” amostral total avaliado nos artigos selecionados foi de 428.149 pessoas, sendo que a maioria dos estudos abordou idosos entre 60-69 anos. A modalidade de atividade física predominante nos estudos foi a caminhada (58,3%), com uma frequência de duas a três vezes por semana (50%) na intensidade moderada (58,3%). Dentre as doenças cardiovasculares (DCV), a hipertensão, o infarto e o acidente vascular cerebral foram as mais prevalentes. A maioria dos estudos incluídos abordou a prevenção, destacando-se a atividade física como um fator protetor para DCV. O presente estudo reuniu informações de que a prática de atividade física de moderada intensidade é um fator protetor ao processo de envelhecimento, além de ser essencial para o controle e prevenção de doenças cardiovasculares.
PERFIL FARMACOTERAPÊUTICO DE PACIENTES COM INSUFICIÊNCIA RENAL CRÔNICA SUBMETIDOS À HEMODIÁLISE EM UM CENTRO DE REFERÊNCIA DO ESTADO DO CEARÁ
Authors: Santiago Francisca Savana , Da Silva Filho José Damião , Loureiro Sara Maria Gonçalves , Souza Louize Emanuele de Oliveira , Belmino Alanna Carla da Costa , Sousa Rosângela Lima , Silva Francisco Wanderlei Lima , Nunes Rodolfo de Melo
Published: June 2023

O regime terapêutico hemodialítico engloba alterações no cotidiano do paciente pacientes com Doença Renal Crônica (DRC) que estão relacionadas às características do tratamento. Este estudo teve como objetivo traçar o perfil farmacoterapêutico de pacientes em tratamento hemodialítico em uma unidade de referência do estado do Ceará (Hospital e Maternidade Divina Providência de Russas - HMDPR).  Tratou-se de um estudo de natureza descritiva, transversal, com análises quantitativas e qualitativas de informações contidas em prontuários. Foram coletadas variáveis socioepidemiológicas, clínicas e as prescrições farmacológicas registradas no período de janeiro a julho de 2020. O estudo avaliou 161 pacientes em terapia renal substitutiva (TRS) e grande parte destes foram do sexo masculino (63,35%), idade média de 53,89 anos e maioria com idade entre 35-44 anos (22,98%). Os Anti-hipertensivos destacaram-se como de maior frequência (15,99%), sendo que 50,94% dos pacientes utilizam 6 a 10 diferentes fármacos concomitantes. Em relação a terapêutica adjuvante à TRS, as principais classes foram os antianêmicos seguida pelos suplementos vitamínicos e mineral. Os dados demonstram que o paciente com DRC necessita de uma atenção diferenciada em sua farmacoterapia, demostrando a importância do profissional farmacêutico junto a equipe multidisciplinar.
Evaluation of the Storms Direct Runoff Prediction Methods used for Goizha-Dabashan Watershed
Authors: Khidir Khalid Mahmoud
Published: June 2023

The Momentum and Aron & White evaluating methods have been adopted to estimate the Nash Instantaneous Hydrograph parameters (IUH), while the two methods of excess rainfall (Ф-index and Natural Resources Conservation Service (NRCS) were applied in a model using a developed computer program in MATLAB to predict the direct runoff hydrograph for Goizha-Dabashan watershed located in the northeast of Iraq. In the verification stage, both Nash IUH optimal parameters of the storms and the average optimal values of the same parameters estimated in the calibration stage were applied and compared. The statistical tests showed a preference for the NRCS method with the momentum method in estimating direct runoff hydrograph (the average Nash-Sutcliffe Efficiency (NSE) was equal to 0.815 and 0.77 using optimal parameters verification storms and the average calibrated IUH parameters values, respectively). Also, satisfactory results (NSE was equal to 0.77 and 0.76 using storm parameters and the average calibrated IUH parameters values, respectively) were obtained by applying Aron & White with the NRCS methods, which indicated the ability of both methods for estimating direct runoff hydrograph.
Numerical Investigations on Low-Speed Aerodynamic Characteristics of Generic Unmanned Combat Aerial Vehicle Configurations
Authors: Aleisa Hassan , Kontis Konstantinos , Nikbay Melike
Published: June 2023

The leading-edge sweep angle significantly influences the flight performance of swept wings. The vortex flow structures affect the flow behavior of the moderate to highly swept wings, which form at low angles of attack because of leading-edge flow separation. This topic of investigation gained momentum due to its application to unmanned combat aerial vehicle (UCAV) configurations that are significantly affected by flow separation at high angles of attack. The present work investigates the flowfield and low-speed aerodynamic characteristics of the generic UCAV models with a constant and nonconstant leading-edge sweep for a wide range of angles of attack. The open-source computational fluid dynamics code OpenFOAM 8.0 is employed for the numerical simulations. The present numerical simulation results agree well with the experimental data in the literature. It is demonstrated that the lift and drag characteristics of the UCAV are sensitive to the leading-edge sweep angle, and a nonconstant leading-edge sweep angle variant exhibits delayed stall and enhanced aerodynamic performance.
Hipercolesterolemia Familiar Homozigótica
Authors: Flora Maria Clara do Vale , Bracci Giovanna de Azevedo Chagas , Azeredo Lucas Marques , Cury Natasha Tanus , Egger Pedro Acácio Lemos , Siqueira Emílio Conceição de
Published: June 2023

Objetivo: Analisar as características da Hipercolesterolemia Familiar Homozigótica (HoFH). Revisão bibliográfica: A causa mais comum de hipercolesterolemia grave é a hipercolesterolemia familiar homozigótica afetando 1 em 300.000 pessoas. Normalmente, a HoFH é herdada de forma codominante e é causada por mutações bialélicas no gene que codifica o receptor de lipoproteína de baixa densidade (LDLR), que representa a principal via de remoção de partículas de LDL do sangue. O perfil lipídico típico da HoFH é caracterizado por LDL-C elevado (até 300 mg/dL) com subsequentemente aumento dos níveis de colesterol total. Considerações finais: A HoFH é uma doença desafiadora única que traz consigo as múltiplas pressões de urgência para tratar, acesso ao tratamento e aconselhamento genético. O tratamento requer primariamente mudança de estilo de vida com dieta e atividade física. A terapêutica com estatinas e inibidores da proproteína convertase subtilisina kexina tipo 9 (PCSK9) são modestamente eficazes apenas se houver receptor de LDL residual atividade. Outra terapia comumente aplicada é a aférese de lipoproteínas, entretanto é uma terapêutica cara, pouco disponível e que por sua posologia semanal ou quinzenal causa implicações na qualidade de vida do paciente.
Rastreamento do câncer do colo do útero no Ceará, entre os anos de 2017 a 2021
Authors: Moura Larissa Clementino de , Filgueiras Thaynara Ferreira , Brandão Monísya Oliveira Ferreira , Xavier Bárbara Letícia de Queiroz , Filgueiras Thiago Ferreira , Narciso Antônio Carlos , Pereira Jéssica Barreto
Published: June 2023

Objetivo: Análise acerca da realização do exame citopatológico do colo do útero no estado do Ceará entre os anos de 2017 a 2021. Métodos: Trata-se de um estudo transversal, com abordagem quantitativa, que utilizou dados secundários do Sistema de Informação do Câncer do Colo do Útero. Resultados: No período supracitado estudado, registrou-se um total de 1.399.285 exames. Acerca do motivo da realização destes, foram apresentados os seguintes percentuais: rastreamento (97,8%), repetição (1,03%) e seguimento (1,25%). Observou-se que ao longo dos anos a grande maioria das amostras foram classificadas como satisfatória em média 99,2% do quantitativo total. No entanto, das 1.399.285 de amostras coletadas, 7.386 foram avaliadas como insatisfatórias e 2901 rejeitadas pelo laboratório. Quanto à representatividade da junção escamo-colunar, 60,73% das amostras coletadas apresentaram resultado positivo para tal achado. Conclusão: Conclui-se que se faz necessário o desenvolvimento e aplicação de estratégias que aproximem o público do serviço e assim proporcionar uma maior adesão do público feminino.
Fatores de risco relacionados à piora de sepse em adultos na Unidade de Terapia Intensiva
Authors: Marques Daiane Silva , Calage Sandra da Silva , Castro Denise Espindola , Faturi Carina Luzyan Nascimento , Alves Ana Paula da Penha , Calado Ana Beatriz de Melo , Subrinho Douglas de Oliveira , Freitas Elder Santos , Ramos Ramon Silva , Silva João Pedro Almeida Soares
Published: June 2023

Objetivo: Identificar os fatores de risco relacionados à piora de sepse em adultos na Unidade de Terapia Intensiva (UTI). Métodos: Trata-se de uma Revisão Integrativa (RI) de caráter descritivo e exploratório. Com o propósito de desenvolver a questão norteadora, aplicaram-se os domínios da estratégia PECo. Efetuou-se um levantamento científico em abril de 2023 nas bases de dados: LILACS e MEDLINE via BVS e Embase via Cochrane Library. Selecionaram-se como descritores os DeCS e MeSH, na qual ambos foram interligados pelo operador booleano AND. Assim, 10 artigos científicos foram selecionados para compor a amostra final. Resultados: Os fatores de risco correlacionados ao agravamento de sepse na UTI foram: faixa etária superior a 65 anos, período médio de internação superior a cinco dias, existência de comorbidades (Diabetes Mellitus, Hipertensão Arterial Sistêmica e neoplasias) e a alta constância da utilização de métodos invasivos. Considerações finais: Verificou-se que a faixa etária elevada, o tempo prologado na UTI, bem como a existência de comorbidades foram os fatores de risco mais comuns que induziram a piora da sepse na UTI.
Combination of PARPi and anti-PD-L1 therapies in ovarian cancer
Authors: Morand Susan M. , Ngo Nealie T. , Mitchell Anthony C. , McHugh Michael A. , Mack Sean T. , Kaur Punit , Asea Alexzander
Published: June 2023

Ovarian cancer affects one in 72 female patients in America, and nearly half of the females who carry a BRCA1/2 mutation will be diagnosed in their lifetime. At present, treatment options such as immune checkpoint inhibitors (ICI) and poly (ADP-ribose) polymerase inhibitors (PARPi) are effective against ovarian cancer in a subset of the population. In this article, we review important combination therapeutics that maximize the benefits of these agents in as many patients as possible. PARPi targets deoxyribonucleic acid (DNA) repair mechanisms inside malignant cells, inducing cell death through synthetic lethality. ICIs target immunogenic antigens expressed on the surface of malignant cells so that the immune system can eliminate cancer cells. There is a direct relationship between the degree of DNA damage, also known as the tumor mutational burden and the effectiveness of ICIs. This principle suggests that treatments combining PARPi and ICI may allow DNA damage to accumulate by interrupting repair mechanisms, which may result in newly expressed antigens that could be targeted by the bolstered immune system. In addition, heat-shock proteins (Hsps) are upregulated during cellular stress, such as the stress elicited by the immense metabolic demand of cancer cells. Hsp has potential as prognostic biomarkers, and further, study is required to see how they interact with treatment options. More specifically, both Hsp60 and Hsp10 may represent a prognostic biomarker for ovarian cancer, and further, research into their mechanisms is important. ICI and PARPi combinatorial therapies for ovarian cancer may extend the benefits of each drug to a larger population, and Hsp represents an opportunity for predicting outcomes and tracking responses in cancer patients.
Targeted therapy with trametinib in infantile refractory langerhans cell histiocytosis: A case report
Authors: Khandelwal Vipin , Bala Saroj , Sharma Sanjeev
Published: June 2023

Langerhans cell histiocytosis (LCH) is a rare hematologic neoplasm characterized by a clonal proliferation of Langerhans-like cells. LCH affects all ages and in children with a frequency ranging from 4.1 to 8.9/million/year with an increased incidence in children <1 year of age. Infantile LCH refractory to frontline therapy is difficult to treat but targeted therapies in patients with BRAF mutations are promising. We treated an infant of refractory multisystem LCH with risk organ involvement with MAP kinase inhibitor (trametinib) with excellent outcomes.
E-government and Participation: Public Engagement in Italian Government Websites
Authors: Di Bonaventura Jacopo , Prencipe Antonio , Boffa Danilo
Published: June 2023

Communication skills between institutions and their citizens have assumed, in recent years, a vital importance within the decision-making processes. The study aims to investigate the interactional communication relationship between the public body and Italian citizens. In particular, the research focuses on the impact of the quality of IT services on encouraging citizens to use and participate in them. The theoretical framework deployed in the research is based on the managerial component of the Technology Acceptance Model (TAM), an application branch of the reasoned action theory. The study adopts an empirical method based on web content analysis, conducted on the institutional sites of the Italian provinces, in order to assess the quality of the e-government services provided.
Managing Learning Environment in Schools for improved Quality Education in the Post-COVID 19 Era
Authors: Joseph Eme , Egwuasi Princewill
Published: June 2023

Any education that is not qualitative enough would impose more danger to the learners and the society at large. This study examined managing the learning environment in schools for improved quality education. The secondary school was the focus while the principals were the target. The presentation of the meaning of learning environment and quality education was captured. The study also explained who the principal is and his responsibilities concerning the educational managerial conception. The study looked at the various components of the learning environment and how they could be managed to produce an acceptable learning environment and its implication in the post-COVID 19 eras. In the end, the paper concluded, among other things, that it is only when the principals are innovative, creative and proactive with their understanding of the learning environment that the desired quality education can be achieved.
A perception on customer relationship management as a tool of information technology
Authors: Sakunthala A.
Published: June 2023

Information technology is a dominant area in today’s world with its ever increasing importance in every aspect of life and is the backbone of the Indian economy. Information Technology brings out many other different technologies inherent in this field along with their impact and how it makes them easier to use, create, manage and exchange information. Customer Relationship Management (CRM) is becoming an important factor in Indian Information Technology (IT) sector as each and every company in IT is realizing the significance of customer satisfaction to survive in the competitive world.
Is small beautiful ? L’irrigation dans le delta du fleuve Sénégal, une question de taille
Authors: Sylla El Hadji Malick , Barbier Bruno , Seck Sidy Mohamed , Damme Patrick Van , Niang Souleymane , Faye Cheikh Ahmed Tidiane
Published: June 2023

Description du sujet. Le débat sur la relation entre la taille des exploitations agricoles et les résultats de production est ancien, mais il n’est pas encore tranché. Au Sénégal, ce débat est alimenté par le fait que les gouvernements récents tendent à favoriser des exploitations irriguées de grande taille, alors que les premiers périmètres distribués étaient de très petites parcelles. Objectifs. Cet article contribue à identifier, dans une zone où il y a des grandes et des petites exploitations, le type d’exploitation qui produit le plus et qui a les meilleurs rendements. Méthode. Une enquête a été réalisée auprès de 326 ménages de riziculteurs dans les communes de Diama et de Ross Béthio, sises dans le delta du fleuve Sénégal. Résultats. Les petites exploitations obtiennent de meilleurs rendements mais leurs revenus globaux sont trop faibles. Les plus grandes exploitations rizicoles réalisent des rendements moins importants mais permettent à leurs exploitants d’obtenir des revenus suffisants pour vivre et faire fonctionner l’exploitation. Selon nos enquêtes, les couts de production sont les principaux facteurs explicatifs des rendements parmi les riziculteurs enquêtés. Les petits producteurs ont des couts de production relativement élevés pour maximiser leur profit là où les grands exploitants limitent les couts de production pour obtenir des rendements qui restent acceptables pour un revenu d’exploitation décent. Conclusions. Pour mieux lutter contre la pauvreté et atteindre l’autosuffisance en riz, les politiques agricoles devraient permettre aux petits cultivateurs de capter de nouveaux investissements et encourager les grands producteurs à investir plus dans la riziculture afin d’augmenter leurs rendements et leurs profits.
Editorial: Jugendliche Systemsprenger:innen: (Gesellschaftliche) Diagnose, Intervention, Abbrüche und Umplatzierungen
Authors: Humm Jakob , Zwahlen Eveline
Published: June 2023

„Systemsprenger:innen“ – ein kontrovers und vielfältig diskutierter Begriff. Das vorliegende Schwerpunktheft versammelt aktuelle Beiträge rund um das Phänomen, wobei gesellschaftliche und organisatorische Strukturen ebenso in den Blick genommen werden wie das Erleben von Kindern und Jugendlichen selbst, die als „Systemsprenger:innen“ etikettiert werden. Die vier empirischen und der theoretische Beitrag zum Themenschwerpunkt werden ergänzt durch einen freien Beitrag zur Fridays for Future-Bewegung sowie einer Rezension zum Buch „Widerstand als Selbstbehauptung“.
Logiken von gesprengten und sprengenden Systemen
Authors: Langnickel Robert , Behringer Noëlle , Link Pierre-Carl
Published: June 2023

Innerhalb der wissenschaftlichen Literatur zum Phänomen „Systemsprenger:innen“ findet sich überwiegend eine Gegenstandsbestimmung für aktive „Systemsprenger:innen“, d. h. der Fokus liegt auf Kindern und Jugendlichen mit herausforderndem Verhalten, das in der Sonderpädagogik in einem weiten Begriffsverständnis als „externalisierend“ eingeordnet wird (Myschker/Stein 2018). Jugendliche, die internalisierende Symptome wie bspw. Angst oder Depression zeigen – die zu den statistisch häufigsten psychischen Erkrankungen im Kindes- und Jugendalter zählen (BELLA-Studie: Ravens-Sieberer et al. 2007) –, werden im wissenschaftlichen pädagogischen Diskurs um „Systemsprenger:innen“ bislang nicht explizit berücksichtigt (Baumann 2020; Ahrbeck 2022; Zimmermann/Weiss 2022;) und sind auch im öffentlichen Diskurs (Heuer 2022, 35) unterrepräsentiert. Deshalb argumentiert der Beitrag für den Begriff der passiven „Systemsprenger:innen“’ und zeigt, dass eine differenzierte Sichtweise angeraten ist, um den Phänomenbereich besser begrifflich zu fassen und angemessener adressieren zu können. Aufgezeigt wird ein mögliches Verständnis passiver „Systemsprenger:innen“, die sich den Anforderungen der Gesellschaft und den pädagogischen Organisationen sowie Institutionen verweigern, ohne jedoch manifest aggressiv oder hyperaktiv zu agieren.
Rezension zu: Preite, Luca (2022): Widerstand als Selbstbehauptung. „Gefährdete“ Jugendliche im Übergangs- und Berufsbildungssystem. Bielefeld: transcript, 166 Seiten, ISBN: 978-3-8376-6344-0, Print: 34,00 €, Open Access
Authors: Fischer Andreas
Published: June 2023

In diesem Buch geht es um die Frage, wie sogenannte „gefährdete“ Jugendliche ihre Werdegänge und Lebenswelten im Rahmen verzögerter Berufs- und Bildungslaufbahnen erfahren, gestalten und behaupten – sowohl trotz der, wegen der, aber auch wider die Voraussage ihrer eigenen Gefährdung. Die Studie lässt sich in einer kritisch-subjektorientierten Forschung verorten.
Water Oil Emulsions Studied by Vibrational Sum Frequency Generation
Authors: El-Zohry Ahmed , Solling Theis
Published: June 2023

Interfacial interactions between water and oil phases are present in various fields, in which other additives, such as surfactants, are utilized to minimize the surface stress between these phases to form an emulsion. However, the consequence of adding additives is not always easy to understand or to control, due to the plethora of parameters that control the production of an emulsion phase. There are several macroscopic techniques to study the properties of emulsions. Nevertheless, these techniques cannot describe the mechanistic steps at molecular level for interfaces with nanometer thicknesses. Among surface sensitive techniques, VSFG (vibrational sum frequency generation) has been utilized to study various parameters that control the formation of surfactant monolayers at water-oil interfaces. In this brief-review, basics about utilization of VSFG along with recent advances for studying the water-oil interfaces will be presented, aiming at familiarizing other scientists with the current understanding of the water-oil interfaces as studied by VSFG
Zirconium Coordination Chemistry and its Role in Optimizing Hydroxymate Chelation: Insights from Molecular Dynamics
Authors: Sormani Giulia , Korde Aruna , Rodriguez Alex , Denecke Melissa , Hassanali Ali
Published: June 2023

In the last decade, there has been a growth in using Zirconium-89 (89 Zr) as a radionuclide in nuclear medicine for cancer diagnostic imaging and drug discovery processes. One of the most popular chelators for 89 Zr, is desferrioxamine (DFO) which acts as a hexadentate ligand. The coordination structure of the Zr4+-DFO complex has primarily been informed by DFT-based calculations which typically ignore temperature and therefore entropic and dynamic solvent effects. In this work, free energy calculations using molecular dynamics simulations, where the conformational fluctuations of both the ligand and the solvent are explicitly included, are used to compare the binding of Zr4+ cation with two different chelators, DFO and 4HMS, the latter of which has been recently proposed as a better chelator. We find that thermal induced disorder leads an open hexadentate chelate structure of Zr4+-DFO complex, leaving the Zr4+ metal exposed to the solvent. A stable coordination of Zr4+ with 4HMS, however, is formed involving both hydroxamate groups and water molecules in a more closely packed structure.
Control of H-related defects in γ-MnO2 in a hydrothermal synthesis
Authors: Magnard Nicolas , Kirsch Andrea , Jørgensen Mads R. V. , Kantor Innokenty , Sørensen Daniel R. , Huotari Simo , Rudic Svemir , Bordallo Heloisa N. , Jensen Kirsten
Published: June 2023

Manganese dioxide is a good candidate for effective energy storage and conversion as it possesses a rich electrochemistry. The compound also shows a wide polymorphism. The γ-variety, an intergrowth of β- and R-MnO2, has been extensively studied in several types of batteries (e.g. Zn/MnO2, Li-ion) and is a common electrode material for commercial batteries. It is well known that the insertion of protons thermodynamically stabilises γ-MnO2 with respect to β-MnO2. Protons can enter the structure either by forming groups of 4 hydroxyls around a Mn4+ vacancy, called a Ruetschi defect, or by forming a hydroxyl group near a Mn3+ ion, called a Coleman defect. These defects differently affect the electrochemistry of manganese oxide, and tailoring their amount in the structure can be used to tune the material properties. Previous studies have addressed the proton insertion process, but the role of the synthesis pathway on the amount of defects created is not well understood. We here investigate how the parameters in a hydrothermal synthesis of γ-MnO2 nanoparticles influence the amount and type of H-related defects. Structural investigations are carried out using Pair Distribution Function analysis, X-ray absorption spectroscopy, thermogravimetric analysis, and inelastic neutron scattering. We demonstrate the possibility to control the amount and type of defects introduced during the synthesis. While the amount of Ruetschi defects increases with synthesis temperature, it decreases with extended synthesis time, along with the amount of Coleman defects. Moreover, we discuss the arrangement of the defects in the γ-MnO2 nanoparticles.
Data-driven imputation of miscibility of aqueous solutions via graph-regularized logistic matrix factorization
Authors: Behnoudfar Diba , Simon Cory , Schrier Joshua
Published: June 2023

Aqueous, two-phase systems (ATPSs) may form upon mixing two solutions of independently water-soluble compounds. Many separation, purification, and extraction processes rely on ATPSs. Predicting the miscibility of solutions can accelerate and reduce the cost of the discovery of new ATPSs for these applications. Whereas previous machine learning approaches to ATPS prediction used physicochemical properties of each solute as a descriptor, in this work, we show how we can impute missing miscibility outcomes directly from an incomplete collection of pairwise miscibility experiments. We use graph-regularized logistic matrix factorization to learn a latent vector of each solution from (i) the observed entries in the pairwise miscibility matrix and (ii) a graph (nodes: solutes, edges: shared relationships) indicating the general category of the solute (i.e., polymer, surfactant, salt, protein). Using an experimental dataset of the pairwise miscibility of 68 solutions from Peacock et al. [ACS Appl. Mater. Interfaces 2021, 13, 9], we show that graph-regularized logistic matrix factorization more accurately predicts missing (im)miscibility outcomes of pairs of solutions than ordinary logistic matrix factorization and random forest classifiers using physicochemical features of the compounds.
On Radon Barycenters of Measures on Spaces of Measures
Authors:   Lomonosov Moscow State University, Bogachev V. I. ,   National Research University Higher School of Economics,   Saint Tikhon’s Orthodox University,   Moscow Center for Fundamental and Applied Mathematics, Popova S. N. ,   National Research University Higher School of Economics,   Moscow Institute of Physics and Technology (State University)
Published: June 2023

We study metrizability of compact sets in spaces of Radon measures with the weak topology. It is shown that if all compacta in a given completely regular topological space are metrizable, then every uniformly tight compact set in the space of Radon measures on this space is also metrizable. It is proved that the property that compact sets of measures on a given space are metrizable is preserved for products of this space with spaces that can be embedded into separable metric spaces. In addition, we construct a Radon probability measure on the space of Radon probability measures on a completely regular space such that its barycenter is not a Radon measure.
Locally Finite Groups Saturated with Direct Product of Two Finite Dihedral Groups
Authors:   Siberian Federal University, Kukharev A. V. , Shlepkin A. A. ,   Siberian Federal University
Published: June 2023

In the study of infinite groups, as a rule, some finiteness conditions are imposed. For example, the group is required to be periodic, Shunkov group, Frobenius group, locally finite group. The concept of saturation makes it possible to effectively establish the internal structure of various classes of infinite groups. To date, a large array of results on groups saturated with various classes of finite groups has been obtained. Another important direction in the study of groups with saturation conditions is the study of groups saturated with direct products of various groups. In this paper, a partial solution to the problem of B. Amberg and L.S. Kazarin on periodic groups saturated with dihedral groups in the class of locally finite groups. The structure of a locally finite group saturated with a direct product of two finite dihedral groups is established and it is proved that in this case the group is solvable. The result obtained is an important step towards solving the problem of Amberg and Kazarin.
Pelatihan Pemanfaatan Barang Bekas Didesa Gebangbunder
Authors: Agus T Hidayat  , Ahmad B Isyqi
Published: June 2023

The utilization of used goods, especially patchwork in Plandaan District, is still not utilized optimally, especially by local women in Gebangbunder village. This Community Service activity aims to optimize the utilization of used goods into valuable goods in Gebangbunder village so that they become products that have economic value. This Community Service activity will be carried out intensively for 1 month in February 2023 with an agreed schedule between the writing team and fostered partners. From the results of intensive activities that have been carried out, satisfactory results are obtained. Fostered partners are able to create their own products and have social media to improve product branding. From the results of Community Service activities that have been carried out, it is hoped that this program can be continued by the local village government so that fostered partners will grow.

Keywords : Entrepreneur, Second-hand goods, Gebangbunder
Penyusuanan Pembukuan Keuangan Badan Usaha Milik Desa (BUMDes) Joko Sambang Guna Kelancaran Kegiatan Organisasi
Authors: Siti Zuhroh  , Wildan Haritsyah
Published: June 2023

Megaluh Village has a Bumdes which has been funded by the government under the name Bumdes Joko Sambang but in terms of financial bookkeeping it is not optimal. This community service activity aims to optimize the management of BUMDes financial accounting to make it easier to control BUMDes operations and train administrators for BUMDes operational activities. This community services activity was carried out intensively for 1 month in February 2023 with a schedule that had been agreed upon between the writing team and the fostered partners, from the results of the intensive activities that had been carried out, satisfactory results were obtained, the fostered partners were able to carry out Bumdes financial accounting and could also continue organized bookkeeping. From the results of the community services activities that have been carried out, it is hoped that this program can be continued by the local village government so that the fostered partners will develop further

Keywords: BUMDes Megaluh, bookkeeping
PROFESSORAS LÉSBICAS: EM QUE RAIOS DE SILÊNCIO PODEMOS ENCONTRÁ-LAS
Authors: Da Silva Zuleide Paiva , De Souza Carvalho Maria Inez da Silva
Published: June 2023

Este estudo exploratório, de natureza quanti-qualitativa, é um produto de pesquisa pós-doutoral realizada no Programa de Pós-Graduação da Faculdade de Educação da Universidade Federal da Bahia. Caracterizado como um estudo de correlatos, foca em experiências e narrativas de professoras lésbicas. Situado no campo dos estudos lesbofeministas, apreende professora lésbica como corpo político, pessoa estigmatizada pela sociedade heterossexual. Reconhecendo a invisibilidade lésbica como problema, uma face da lesbofobia, percebida como  violência estrutural que ameaça, agride e mata mulheres em função do imbricamento do gênero, da sexualidade não heterossexual e da raça, entre outros marcadores da diferença, o estudo questiona em que raios de silêncio e obscuridade podemos encontrar as professoras lésbicas? Em busca de respostas, o objetivo é analisar como as experiências de professoras lésbicas são perspectivadas nos estudos disponíveis na base de dados Norte-Americana ERIC - Education Resources Information Center. A metodologia é inspirada no método Systematic Search Flow. O resultado é um mapa em aberto, aponta que a experiência de violência sofrida pelas lésbicas no ambiente de trabalho, e fora dele, é refletida como “homofobia”, fato que sugere não reconhecimento das especificidades da violência contra lésbicas, além de sugerir que não há existência segura para professoras lésbicas.