bluuebunny/crossref_metadata_2025 huggingface dataset:
Prevalence and Factors Influencing Self-Medication among Pregnant Women Attending Antenatal Clinics in Urban Tertiary Hospitals in Nigeria
Authors: Edet Clement Kevin , Wegbom Anthony Ike , Samuel Kitoye Gentle , Sapira-Ordu Leesi , Jaja Ishmeal Daniel , Ene-Peter Janet , Harold Isaac , Onyema Chinemere , Pepple Biteegeregha Godfrey , Fagbamigbe Adeniyi Francis
Published: March 2023

Despite the adverse effects of self-medication (SM), such as antimicrobial drug resistance, drug addiction, allergy, worsening of ailment, organ damage, disability, and death, the practice is still common and increasingly practiced globally, even among pregnant women. This study investigated the prevalence and factors influencing self-medication among pregnant women attending antenatal clinics in urban tertiary hospitals in Nigeria. A facility-based cross-sectional study was carried out in two tertiary hospitals in Port Harcourt between 25 September and 24 October 2022, using an interviewer-administered questionnaire. Data were analyzed using descriptive and logistics regression techniques, and statistical significance was set at p < 0.05. A total of 413 respondents participated in the study. The prevalence of SM was 31.0% (95% CI = 26.7–73.3). Women who were not married and those with less than secondary education had the highest prevalence, 60.5% (95% CI = 45.1–74.0) and 51.1% (95% CI = 42.7–59.4), respectively. The common drugs used for SM were Paracetamol, antimalarials, antibiotics, cough and cold medicines, and herbal products. While the reasons for SM were emergency illness, high cost at health facilities, and distance to the health facility. The commonest illnesses/symptoms that necessitated SM included body pain, headache, fever, cold and cough, and vaginal discharge. Married women and those educated above the secondary level had lower odds of practicing SM compared to their counterparts; married (AOR = 0.37, 95% CI = 0.18–0.78) and >secondary level (AOR = 0.31, 95% CI = 0.18–0.51). This study showed that a significant proportion of pregnant women practiced SM and marital status and educational level were the factors influencing SM in the studied population. We recommend public health education and reproductive health programmes aimed at discouraging unmarried women and those with minimal education from the irrational use of drugs during pregnancy.
Factors Predicting Type I Gastric Neuroendocrine Neoplasia Recurrence: A Single-Center Study
Authors: Sheikh-Ahmad Mohammad , Saiegh Leonard , Shalata Anan , Bejar Jacob , Kreizman-Shefer Hila , Sirhan Majd F. , Matter Ibrahim , Swaid Forat , Laniado Monica , Mubariki Nama , Rainis Tova , Rosenblatt Ilana , Yovanovich Ekaterina , Agbarya Abed
Published: March 2023

Type I gastric neuroendocrine neoplasms (gNENs) are associated with atrophic gastritis and have a high recurrence rate, which means frequent endoscopies are required. The objective of this study was to identify factors predicting the local recurrence of type I gNENs. The clinical course and the pathological and biochemical data of patients with type I gNENs treated at Bnai Zion Medical Center between 2006 and 2022 were analyzed retrospectively. Twenty-seven type I gNENs were evaluated. The follow-up period was 41 months (range: 11–288 months). Recurrence of the tumor occurred in 13/27 (48%) patients after 35 months (median (M), interquartile range (IQR): 21–67.5). Serum gastrin levels were significantly higher in patients with recurrent disease versus patients with non-recurrent disease (788 vs. 394 ng/L; p = 0.047), while the Ki-67 index was significantly lower in patients with recurrent disease versus patients with non-recurrent disease (1% vs. 3.5%; p = 0.035). Tumor size, mitotic count, and serum chromogranin A levels did not correlate with recurrence. The present study emphasizes the role of gastrin in the pathogenesis of gNEN recurrence and highlights the debate regarding the ability of the Ki-67 index to predict the clinical course of this disease.
PINK1 and Parkin Ameliorate the Loss of Motor Activity and Mitochondrial Dysfunction Induced by Peripheral Neuropathy-Associated HSPB8 Mutants in Drosophila Models
Authors: Kang Kyong-hwa , Han Ji Eun , Kim Hyunjin , Kim Sohee , Hong Young Bin , Yun Jeanho , Nam Soo Hyun , Choi Byung-Ok , Koh Hyongjong
Published: March 2023

Charcot–Marie–Tooth disease (CMT) is a group of inherited peripheral nerve disorders characterized by progressive muscle weakness and atrophy, sensory loss, foot deformities and steppage gait. Missense mutations in the gene encoding the small heat shock protein HSPB8 (HSP22) have been associated with hereditary neuropathies, including CMT. HSPB8 is a member of the small heat shock protein family sharing a highly conserved α-crystallin domain that is critical to its chaperone activity. In this study, we modeled HSPB8 mutant-induced neuropathies in Drosophila. The overexpression of human HSPB8 mutants in Drosophila neurons produced no significant defect in fly development but led to a partial reduction in fly lifespan. Although these HSPB8 mutant genes failed to induce sensory abnormalities, they reduced the motor activity of flies and the mitochondrial functions in fly neuronal tissue. The motor defects and mitochondrial dysfunction were successfully restored by PINK1 and parkin, which are Parkinson’s disease-associated genes that have critical roles in maintaining mitochondrial function and integrity. Consistently, kinetin riboside, a small molecule amplifying PINK1 activity, also rescued the loss of motor activity in our HSPB8 mutant model.
Mid-Infrared Spectroscopy as a New Tool for Ruling Out Spontaneous Bacterial Peritonitis: A Proof-of-Concept Study
Authors: Farrugia Marwin A. , Le Corvec Maëna , Renou Christophe , Nousbaum Jean-Baptiste , Ouizeman Dann J. , Sire Olivier , Loréal Olivier , Tariel Hugues , Bernard Jérôme , Piche Thierry , Tran Albert , Ait-Oufella Hafid , Landraud Luce , Gual Philippe , Anty Rodolphe ,   the Cytokine Ascites Group
Published: March 2023

Background and aims: A highly sensitive and specific point-of-care method for diagnosing spontaneous bacterial peritonitis (SBP) is currently lacking. The objective of the present study is to evaluate the diagnostic value of a rapid, easy-to-use, mid-infrared fiber evanescent wave spectroscopy (MIR-FEWS) method for ruling out SBP. Patients and Methods: Cirrhotic patients (n = 256) at five centers in France were included for suspected SBP or for the scheduled evacuation of ascites fluid. The mid-infrared spectrum of 7 µL of an ascites fluid sample was recorded using a MIR-FEWS system. To define a model for the diagnosis of SBP, the patients were divided into a calibration group (n = 170) and a validation group (n = 86). Results: Most of the patients were male (71%). The mean age was 60.25 years. Alcohol-related liver disease was the most common cause of cirrhosis. SBP was observed in 18% of the patients. For the diagnosis of SBP in the calibration and validation groups, respectively, the model gave areas under the receiver operating characteristic curves of 0.87 and 0.89, sensitivities of 90% and 87%, specificities of 78% and 80%, positive predictive values of 48% and 50%, negative predictive values of 97% and 96%, positive likelihood ratio of 4.09 and 4.35, negative likelihood ratio of 0.13 and 0.16, Youden index of 0.68 and 0.67, and correct classification rates of 80% and 81%. Conclusion: The results of this proof-of-concept study show that MIR-FEWS is a highly sensitive diagnostic method for ruling out SBP. The method warrants further investigation.
Recent Clinical Treatment and Basic Research on the Alveolar Bone
Authors: Tsuchida Sachio , Nakayama Tomohiro
Published: March 2023

The periodontal ligament is located between the bone (alveolar bone) and the cementum of the tooth, and it is connected by tough fibers called Sharpey’s fibers. To maintain healthy teeth, the foundation supporting the teeth must be healthy. Periodontal diseases, also known as tooth loss, cause the alveolar bone to dissolve. The alveolar bone, similar to the bones in other body parts, is repeatedly resorbed by osteoclasts and renewed by osteogenic cells. This means that an old bone is constantly being resorbed and replaced by a new bone. In periodontal diseases, the alveolar bone around the teeth is absorbed, and as the disease progresses, the alveolar bone shrinks gradually. In most cases, the resorbed alveolar bone does not return to its original form even after periodontal disease is cured. Gum covers the tooth surface so that it matches the shape of the resorbed alveolar bone, exposing more of the tooth surface than before, making the teeth look longer, leaving gaps between the teeth, and in some cases causing teeth to sting. Previously, the only treatment for periodontal diseases was to stop the disease from progressing further before the teeth fell out, and restoration to the original condition was almost impossible. However, a treatment method that can help in the regeneration of the supporting tissues of the teeth destroyed by periodontal diseases and the restoration of the teeth to their original healthy state as much as possible is introduced. Recently, with improvements in implant material properties, implant therapy has become an indispensable treatment method in dentistry and an important prosthetic option. Treatment methods and techniques, which are mainly based on experience, have gradually accumulated scientific evidence, and the number of indications for treatment has increased. The development of bone augmentation methods has contributed remarkably to the expansion of indications, and this has been made possible by various advances in materials science. The induced pluripotent stem cell (iPS) cell technology for regenerating periodontal tissues, including alveolar bone, is expected to be applied in the treatment of diseases, such as tooth loss and periodontitis. This review focuses on the alveolar bone and describes clinical practice, techniques, and the latest basic research.
Acute Kidney Injury Associated with Severe SARS-CoV-2 Infection: Risk Factors for Morbidity and Mortality and a Potential Benefit of Combined Therapy with Tocilizumab and Corticosteroids
Authors: Iglesias Jose , Vassallo Andrew , Ilagan Justin , Ang Song Peng , Udongwo Ndausung , Mararenko Anton , Alshami Abbas , Patel Dylon , Elbaga Yasmine , Levine Jerrold S.
Published: March 2023

Background: Acute kidney injury (AKI) is a common complication in patients with severe COVID-19. Methods: We retrospectively reviewed 249 patients admitted to an intensive care unit (ICU) during the first wave of the pandemic to determine risk factors for AKI. Demographics, comorbidities, and clinical and outcome variables were obtained from electronic medical records. Results: Univariate analysis revealed older age, higher admission serum creatinine, elevated Sequential Organ Failure Assessment (SOFA) score, elevated admission D-Dimer, elevated CRP on day 2, mechanical ventilation, vasopressor requirement, and azithromycin usage as significant risk factors for AKI. Multivariate analysis demonstrated that higher admission creatinine (p = 0.0001, OR = 2.41, 95% CI = 1.56–3.70), vasopressor requirement (p = 0.0001, OR = 3.20, 95% CI = 1.69–5.98), elevated admission D-Dimer (p = 0.008, OR = 1.0001, 95% CI = 1.000–1.001), and elevated C-reactive protein (CRP) on day 2 (p = 0.033, OR = 1.0001, 95% CI = 1.004–1.009) were independent risk factors. Conversely, the combined use of Tocilizumab and corticosteroids was independently associated with reduced AKI risk (p = 0.0009, OR = 0.437, 95% CI = 0.23–0.81). Conclusion: This study confirms the high rate of AKI and associated mortality among COVID-19 patients admitted to ICUs and suggests a role for inflammation and/or coagulopathy in AKI development. One should consider the possibility that early administration of anti-inflammatory agents, as is now routinely conducted in the management of COVID-19-associated acute respiratory distress syndrome, may improve clinical outcomes in patients with AKI.
Influence of Emotions on Elementary-School Children’s Implicit Learning during a Serial Reaction Time Task
Authors: Mazars Mélanie , Simoës-Perlant Aurélie , Paubel Pierre-Vincent , Lemercier Céline
Published: March 2023

As pedagogues and childhood professionals, teachers must be aware of both implicit and explicit learning processes. They must also bear in mind that learners’ performances may be influenced by the many emotions triggered by different situations at school (e.g., fear of failing, happiness upon succeeding, anger at leaving work unfinished). The objective of the present study was thus to analyze the efficiency of implicit learning among 8- to 11-year-old children and the impact of emotions on this type of learning. In order to analyze implicit learning, 65 elementary-school children performed a serial reaction time task in a laboratory context. Emotions were induced by asking the children to read six short emotional sentences and listen to classical music. Results showed a significant impact of the task condition (semi-random or fixed sequence) on reaction times. Moreover, the induction of happiness resulted in slightly longer reaction times compared with neutral induction. These results need to be deepened to better understand the interactions between emotions and implicit learning in children.
Post-Traumatic Headache in Children after Minor Head Trauma: Incidence, Phenotypes, and Risk Factors
Authors: Dondi Arianna , Biserni Giovanni Battista , Scarpini Sara , Fetta Anna , Moscano Filomena , Corsini Ilaria , Borelli Greta , Cordelli Duccio Maria , Lanari Marcello
Published: March 2023

Minor head trauma (MHT) is very frequent in children and post-traumatic headache (PTH) is one of its most common complications; however, its management is still a challenge. We aimed to assess the incidence and clinical characteristics of, and risk factors for, PTH among children referred to our pediatric emergency department (PED) for MHT. A total of 193 patients aged 3–14 years evaluated for MTH were enrolled and followed up for 6 months through phone calls and/or visits. PTH occurred in 25/193 patients (13%). PTH prevalence was significantly higher in school-aged (≥6 years) than in pre-school-aged children (21.6% vs. 4.9%, respectively, p < 0.009). Females were found to be more affected. The median time of onset was 4.6 days after MHT; resolution occurred in a median of 7 weeks. In 83.3% of patients, PTH subsided in <3 months, while in 16.7% it persisted longer. A total of 25% of children exhibited the migraine and 75% the tension-type variant. Our analysis indicates the presence of headache upon arrival in PED, isolated or associated with nausea and dizziness, as a factor predisposing the patient to the development of PTH. Our findings could be useful to identify children at risk for PTH for specific follow-up, family counseling, and treatment.
Change in Long Non-Coding RNA Expression Profile Related to the Antagonistic Effect of Clostridium perfringens Type C on Piglet Spleen
Authors: Yan Zunqiang , Wang Pengfei , Yang Qiaoli , Gao Xiaoli , Gun Shuangbao , Huang Xiaoyu
Published: March 2023

LncRNAs play important roles in resisting bacterial infection via host immune and inflammation responses. Clostridium perfringens (C. perfringens) type C is one of the main bacteria causing piglet diarrhea diseases, leading to major economic losses in the pig industry worldwide. In our previous studies, piglets resistant (SR) and susceptible (SS) to C. perfringens type C were identified based on differences in host immune capacity and total diarrhea scores. In this paper, the RNA-Seq data of the spleen were comprehensively reanalyzed to investigate antagonistic lncRNAs. Thus, 14 lncRNAs and 89 mRNAs were differentially expressed (DE) between the SR and SS groups compared to the control (SC) group. GO term enrichment, KEGG pathway enrichment and lncRNA-mRNA interactions were analyzed to identify four key lncRNA targeted genes via MAPK and NF-κB pathways to regulate cytokine genes (such as TNF-α and IL-6) against C. perfringens type C infection. The RT-qPCR results for six selected DE lncRNAs and mRNAs are consistent with the RNA-Seq data. This study analyzed the expression profiling of lncRNAs in the spleen of antagonistic and sensitive piglets and found four key lncRNAs against C. perfringens type C infection. The identification of antagonistic lncRNAs can facilitate investigations into the molecular mechanisms underlying resistance to diarrhea in piglets.
Detecting Common Bubbles in Multivariate Mixed Causal–Noncausal Models
Authors: Cubadda Gianluca , Hecq Alain , Voisin Elisa
Published: March 2023

This paper proposes concepts and methods to investigate whether the bubble patterns observed in individual time series are common among them. Having established the conditions under which common bubbles are present within the class of mixed causal–noncausal vector autoregressive models, we suggest statistical tools to detect the common locally explosive dynamics in a Student t-distribution maximum likelihood framework. The performances of both likelihood ratio tests and information criteria were investigated in a Monte Carlo study. Finally, we evaluated the practical value of our approach via an empirical application on three commodity prices.
Feature Interaction-Based Reinforcement Learning for Tabular Anomaly Detection
Authors: Liu Yaoxun , Ma Liangli , Wang Muyuan , Zhang Siyuan
Published: March 2023

Deep learning-based anomaly detection (DAD) has been a hot topic of research in various domains. Despite being the most common data type, DAD for tabular data remains under-explored. Due to the scarcity of anomalies in real-world scenarios, deep semi-supervised learning methods have come to dominate, which build deep learning models and leverage a limited number of labeled anomalies and large-scale unlabeled data to improve their detection capabilities. However, existing works share two drawbacks. (1) Most of them simply treat the unlabeled samples as normal ones, ignoring the problem of label contamination, which is very common in real-world datasets. (2) Only very few works have designed models specifically for tabular data instead of migrating models from other domains to tabular data. Both of them will limit the model’s performance. In this work, we propose a feature interaction-based reinforcement learning for tabular anomaly detection, FIRTAD. FIRTAD incorporates a feature interaction module into a deep reinforcement learning framework; the former can model tabular data by learning a relationship among features, while the latter can effectively exploit available information and fully explore suspicious anomalies from the unlabeled samples. Extensive experiments on three datasets not only demonstrate its superiority over the state-of-art methods but also confirm its robustness to anomaly rarity, label contamination and unknown anomalies.
Demand Response Management via Real-Time Pricing for Microgrid with Electric Vehicles under Cyber-Attack
Authors: Zhu Hongbo , Yin Hui , Feng Xue , Zhang Xinxin , Wang Zongyao
Published: March 2023

The initiative of users to participate in power grid operation is a key factor in realizing the optimal allocation of power. Demand response (DR) management mechanisms based on real-time pricing (RTP) can effectively promote the enthusiasm of users, stimulate the efficiency of microgrids for power dispatch, and achieve the goasl of power peak shifting and valley filling. In this paper, we consider a microgrid composed of several energy providers (EPs) and multiple users, and each user is equipped with several electric vehicles (EVs). It should be noted that EVs may be attacked by networks in the process of data exchange when EVs connect to the MG. In this environment, we establish a multi-time slots social welfare maximization model that reflects the common interests of EPs and users. To simplify the problem, we decompose this multi-time slots model into a set of single-time slot optimization problems by the relaxation method. Furthermore, the mechanisms of identification and processing (MIP) for EVs under cyber-attack are proposed. The problem is decoupled to EPs and users by duality decomposition. Then, through integration with MIP, a distributed RTP algorithm based on the dual subgradient algorithm is designed to obtain the optimal electricity price. Finally, the simulation results verify the feasibility of the model and the effectiveness of the proposed algorithm. Through comparative analysis, the necessity of identifying EVs under cyber-attack is fully embodied.
Kernel Reverse Neighborhood Discriminant Analysis
Authors: Li Wangwang , Tan Hengliang , Feng Jianwei , Xie Ming , Du Jiao , Yang Shuo , Yan Guofeng
Published: March 2023

Currently, neighborhood linear discriminant analysis (nLDA) exploits reverse nearest neighbors (RNN) to avoid the assumption of linear discriminant analysis (LDA) that all samples from the same class should be independently and identically distributed (i.i.d.). nLDA performs well when a dataset contains multimodal classes. However, in complex pattern recognition tasks, such as visual classification, the complex appearance variations caused by deformation, illumination and visual angle often generate non-linearity. Furthermore, it is not easy to separate the multimodal classes in lower-dimensional feature space. One solution to these problems is to map the feature to a higher-dimensional feature space for discriminant learning. Hence, in this paper, we employ kernel functions to map the original data to a higher-dimensional feature space, where the nonlinear multimodal classes can be better classified. We give the details of the deduction of the proposed kernel reverse neighborhood discriminant analysis (KRNDA) with the kernel tricks. The proposed KRNDA outperforms the original nLDA on most datasets of the UCI benchmark database. In high-dimensional visual recognition tasks of handwritten digit recognition, object categorization and face recognition, our KRNDA achieves the best recognition results compared to several sophisticated LDA-based discriminators.
Effects of Pomegranate Peel Extract and/or Lactic Acid as Natural Preservatives on Physicochemical, Microbiological Properties, Antioxidant Activity, and Storage Stability of Khalal Barhi Date Fruits
Authors: Alqahtani Nashi K. , Alnemr Tareq M. , Ali Salim A.
Published: March 2023

The use of natural preservatives in the storage of fresh fruits is a promising approach to healthier and more sustainable food processing. The current study was conducted to evaluate the effect of pomegranate peel extract (PPE) and lactic acid (LA) as natural preservatives on the shelf life of Khalal Barhi date fruits. Physicochemical properties, antioxidant activity, color parameters, texture profile, sensory characteristics, and microbiological quality of date fruits were evaluated during six weeks of cold storage (4 ± 1 °C). The bioactive compounds in PPE were determined by HPLC analysis, which showed that PPE is a rich source of bioactive compounds, particularly phenolics and flavonoids. The results exhibited decreased moisture content (from 68.36–68.43 to 62.13–63.11%) and an increased soluble solids content (from 27.16–27.24 to 31.45–33.91%) in all samples with prolonged storage. Likewise, a slight decrease in the pH (from 6.00–6.28 to 4.89–5.29) with an increase in acidity (from 0.12–0.14 to 0.23–0.27%) during storage was observed. Generally, treated samples showed lower changes in moisture content, soluble solids content, pH, and acidity than the control. A decrease in total phenolic content (TPC) (from 8.22–12.36 to 3.19–5.17 mg GAE/g) and antioxidant activity (from 44.11–68.26 to 23.84–38.52%) of all samples was observed with progressed storage, meanwhile, the treatment with PPE significantly (p < 0.05) increased TPC with a concomitant increase in antioxidant activity and maintained higher values of both throughout storage. The results exhibited a decrease in L* (from 54.87–55.92 to 41.68–45.68) and b* (from 36.25–37.09 to 23.59–25.42) values of all samples, while the a* value of all samples increased (from 1.29–1.40 to 2.22–2.43) with storage. Dipping treatment in PPE solution improved the color, exhibited the lowest change in color parameters, and maintained better texture properties during storage. Similarly, sensory properties decreased (from 8.21–8.66 to 6.71–7.21) during storage with insignificant (p > 0.05) differences among samples. Dipping treatments inhibited the growth of yeasts and molds over time, with the lowest microbial count recorded in the PPE-treated samples. It can be concluded that PPE was found to have protective effects on Khalal Barhi date fruit quality by controlling post-harvest changes and lowering the microbial load.
Microencapsulation of Carotenoid-Rich Extract from Guaraná Peels and Study of Microparticle Functionality through Incorporation into an Oatmeal Paste
Authors: Pinho Lorena Silva , Patel Bhavesh K. , Campanella Osvaldo H. , Rodrigues Christianne Elisabete da Costa , Favaro-Trindade Carmen Sílvia
Published: March 2023

The peels of guaraná (Paullinia cupana) fruit contain abundant carotenoid content, which has demonstrated health benefits. However, these compounds are unstable in certain conditions, and their application into food products can be changed considering the processing parameters. This study aimed to encapsulate the carotenoid-rich extract from guaraná peels by spray drying (SD), characterize the microparticles, investigate their influence on the pasting properties of oatmeal paste, and evaluate the effects of temperature and shear on carotenoid stability during the preparation of this product. A rheometer with a pasting cell was used to simulate the extrusion conditions. Temperatures of 70, 80, and 90 °C and shear rates of 50 and 100 1/s were the parameters evaluated. Microparticles with a total carotenoid content between 40 and 96 µg/g were obtained. Over the storage period, carotenoid stability, particle size, color, moisture, and water activity varied according to the core:carrier material proportion used. Afterward, the formulation SD1:2 was selected to be incorporated in oatmeal, and the paste viscosity was influenced by the addition of this powder. β-carotene retention was higher than that of lutein following the treatment. The less severe treatment involving a temperature of 70 °C and a shear rate of 50 1/s exhibited better retention of total carotenoids, regardless of whether the carotenoid-rich extract was encapsulated or non-encapsulated. In the other treatments, the thermomechanical stress significantly influenced the stability of the total carotenoid. These results suggest that the addition of encapsulated carotenoids to foods prepared at higher temperatures has the potential for the development of functional and stable products.
Proximate Compositions, Texture, and Sensory Profiles of Gluten-Free Bario Rice Bread Supplemented with Potato Starch
Authors: Ronie Macdalyna Esther , Mamat Hasmadi , Abdul Aziz Ahmad Hazim , Zainol Muhd Khairi
Published: March 2023

Current gluten-free food development trends tend to favour pigmented rice flour. Bario Merah Sederhana is a type of red-pigmented rice that is indigenous to Sarawak, Malaysia. This research investigates the nutritional, texture, and sensory properties of gluten-free rice bread produced from a composite of BMS rice flour and potato starch, producing samples referred to as F1 (100:0), F2 (90:10), F3 (80:20), and F4 (70:30). The gluten-free rice bread formulations demonstrated higher ash and crude fibre content and lower carbohydrate content than wheat bread. However, the crude protein content of the bread decreased significantly (p < 0.05) with a decreased amount of rice flour, owing to wheat flour containing greater protein. The crumb of rice bread appeared to be darker due to the red pigment of rice flour; in contrast, the crust was lighter than the control sample, possibly due to a lower Maillard reaction. Among rice bread formulations, F4 demonstrated the lowest hardness in dough and bread, as well as the highest stickiness and springiness in dough and bread, respectively. The wheat bread received the highest rating (p < 0.05) in the sensory test; nonetheless, among the rice breads, F4 was considered to be an acceptable formulation owing to its high score in colour (7.03), flavour (5.73), texture (6.03), and overall acceptability (6.18). BMS has potential in gluten-free rice breads; the formulation of 70% rice flour combined with 30% potato starch was indicated to be acceptable.
Wear Model of a Mechanical Seal Based on Piecewise Fractal Theory
Authors: Ni Xingya , Sun Jianjun , Ma Chenbo , Zhang Yuyan
Published: March 2023

In this research, a model is proposed using piecewise fractal theory that considers abrasive and adhesive wear. The model demonstrated improved wear computation accuracy of a contact mechanical seal end face. The validity of the model was established by comparing the simulation results with experimental data and the conventional MB and Archard models. The loading effect and surface morphology parameters involved in wear were also investigated. Results show that severe wear occurs with increasing load ratio, large fractal dimensions, and a higher scale coefficient of the surface morphology. The findings offer a novel method for precisely calculating and projecting the amount of wear of a contact mechanical seal and predicting its wear behavior.
Fabrication and Applications of Ceramic-Based Nanofiber Materials Service in High-Temperature Harsh Conditions—A Review
Authors: Zhang Jing , Zhang Xi , Wang Lifeng , Zhang Junxiong , Liu Rong , Sun Qilong , Ye Xinli , Ma Xiaomin
Published: March 2023

Ceramic-based nanofiber materials have attracted attention due to their high-temperature resistance, oxidation resistance, chemical stability, and excellent mechanical performance, such as flexibility, tensile, and compression, which endow them with promising application prospects for filtration, water treatment, sound insulation, thermal insulation, etc. According to the above advantages, we, therefore, reviewed the ceramic-based nanofiber materials from the perspectives of components, microstructure, and applications to provide a systematical introduction to ceramic-based nanofiber materials as so-called blankets or aerogels, as well as their applications for thermal insulation, catalysis, and water treatment. We hope that this review will provide some necessary suggestions for further research on ceramic-based nanomaterials.
Long-Term Performance of Monolithic Silica Aerogel with Different Hydrophobicities: Physical and Color Rendering Properties after an Accelerated Aging Process
Authors: Fiorini Costanza Vittoria , Merli Francesca , Belloni Elisa , Carroll Mary K. , Anderson Ann M. , Buratti Cinzia
Published: March 2023

Due to its excellent properties, monolithic silica aerogel is a promising material for innovative glazing systems. Since glazing systems are exposed to deteriorating agents during building service life, it is essential to investigate the long-term performance of aerogel. In the present paper, several 12.7 mm-thick silica aerogel monoliths produced by a rapid supercritical extraction method were tested, including both hydrophilic and hydrophobic samples. After fabrication and characterization of hydrophobicity, porosity, optical and acoustic properties, and color rendering, the samples were artificially aged by combining temperature and solar radiation effects in an experimental device specifically developed at the University of Perugia. The length of the experimental campaign was determined using acceleration factors (AFs). Temperature AF was evaluated according to the Arrhenius law using thermogravimetric analysis to estimate the aerogel activation energy. A natural service life of 12 years was achieved in about 4 months, and the samples’ properties were retested. Contact angle tests supported by FT-IR analysis showed loss of hydrophobicity after aging. Visible transmittance values in the 0.67–0.37 range were obtained for hydrophilic and hydrophobic samples, respectively. The aging process involved optical parameter reduction of only 0.02–0.05. There was also a slight loss in acoustic performance (noise reduction coefficient (NRC) = 0.21–0.25 before aging and NRC = 0.18–0.22 after aging). For hydrophobic panes, color shift values in the 10.2–59.1 and 8.4–60.7 ranges were obtained before and after aging, respectively. The presence of aerogel, regardless of hydrophobicity, results in a deterioration in light-green and azure tones. Hydrophobic samples had lower color rendering performance than hydrophilic aerogel, but this did not worsen after the aging process. This paper makes a significant contribution to the progressive deterioration assessment of aerogel monoliths for applications in sustainable buildings.
Impact of COVID-19 on Portuguese Dental Students: A Cohort Study
Authors: dos Santos Gonçalves Rodrigo Melo , Fernandes Gustavo Vicentis Oliveira , Fernandes Juliana Campos Hasse , Seabra Mariana , Figueiredo Andreia
Published: March 2023

Introduction: The goal of this study was to assess the impact of COVID-19 on Portuguese dental students on their depression, anxiety, temporomandibular dysfunction, academic degree, and oral behaviors. Methods: The target of this population study was to enroll third-, fourth-, and fifth-year students of the Integrated Master’s degree in Dental Medicine at the Universidade Católica Portuguesa—Faculty of Dental Medicine (Viseu, Portugal) in the academic year 2021–2022. Temporomandibular disorders (TMD) symptoms, oral behaviors, anxiety, and depression were assessed using validated questionnaires. The variables under study were (a) age, gender, marital status, academic level, academic degree, medication, and any existing pathologies; (b) questions related to taste changes or thoughts that would indicate (or not) worsening psychological conditions (anxiety and depression). After data collection (Google Forms®), data were transferred to an Excel file and entered into SPSS® software. A chi-square test allowed the independence between ordinal or nominal variables. The Spearman correlation test was used to analyze the relationship between variables in the study (significant if p ≤ 0.05). Results: 98.2% of the students answered the questionnaire. TMD had a prevalence of 35%, and anxiety and depression a prevalence of 29% and 24%, respectively. The results showed that the female gender was the most affected by psychological and temporomandibular disorders. Statistically significant correlations were identified between variables, such as gender and anxiety, TDM, and depression (respectively, p = 0.0001, p = 0.014, and p = 0.026); between TDM and anxiety and depression (respectively, p = 0.001 and p < 0.001); and between performing oral behaviors and TMD, anxiety, and depression (respectively, p = 0.0001, p = 0.0001, and p = 0.006). The variables, such as age and academic degree, did not establish a statistically significant relationship with TMD, oral behaviors, and the two psychological conditions. Conclusions: It was possible to conclude that there was a moderate prevalence of TMD, anxiety, and depression in the period studied. Moreover, a statistically significant relationship was found between TMD, anxiety, and depression with gender and frequency of OBs; however, no significant association was found for TMD, anxiety, and depression with the age of students and with the academic degree.
Comparative Study of Cypripedium Plant Photosynthetic Characteristics from Changbai Mountain
Authors: Chen Lifei , Li Shuang , Li Ying , Zhang Yuqing , Bai Yun , Cong Hao , Liu Wei , Zhou Yunwei
Published: March 2023

This study reports on extensive and in-depth investigations into the morphological, photosynthetic, and physiological indices of 10 different types of Cypripedium plant introduced from Changbai Mountain. It is an important prerequisite for the ex situ conservation of Cypripedium plants to provide new insights into their photosynthesis. This result can not only promote the production of vegetative plants but also promote the production of plants with lots of flowers and the physiological characteristics of Cypripedium plants for promoting the artificial introduction and cultivation of wild resources. A critical comparison of the results showed that high light intensity is one of the causes of the reduction in photosynthesis in the samples. Cypripedium macranthum had the most morphological advantages, while Cypripedium guttatum, the smallest plant type, had the lowest plant morphogenesis. Photoinhibition began daily at 12:00 pm and reached a second peak at 14:00 pm in all 10 types. C. macranthum, Cypripedium ventricosum, and Cypripedium calceolus had greater photosynthetic capacity than the other types. Using principal component analysis, the order of photosynthetic physiological characteristics of the 10 Cypripedium plants was CCMY > CVPP > CCRY > CMPP > CVRR > CSPY > CMWW > CMLL > CMDD > CGWW. These results lay the groundwork for future research on Cypripedium resource distribution and artificial conservation.
Exploring the Relationship between Genomic Variation and Phenotype in Ornamental Pomegranate: A Study of Single and Double-Petal Varieties
Authors: Huo Yan , Yang Han , Ding Wenjie , Yuan Zhaohe , Zhu Zunling
Published: March 2023

The double-petal varieties of ornamental pomegranate have higher ornamental value and garden development potential than the single-petal varieties but there has been no study on the genomic variation between them. This study aimed to determine the genomic variation between the two kinds of varieties and the relationship between the variation and phenotype by identifying the DNA variation of three single-petal varieties and three double-petal varieties using re-sequencing technology. The results showed that the variation number of each variety was in the order of single nucleotide polymorphisms (SNPs) > insertions and deletions (InDels) > structural variations (SVs) > copy number variations (CNVs). The number of SNPs and InDels in the double-petal varieties was significantly higher than that in the single-petal varieties, and there was no significant difference in the number of SVs and CNVs. The number of non-synonymous SNPs in the coding region (Nonsyn_CDS_SNPs) and InDels with a 3X length in the coding region (3X_shiftMutation_CDS_InDel) was significantly higher in the double-petal varieties than that in the single-petal varieties. The number of the two variants was strongly positively correlated with each morphological index that was related to the phenotypic difference between the two varieties. Nonsyn_CDS_SNPs and 3X_shiftMutation_CDS_InDel were enriched in the cell membrane system, cell periphery, and signal transduction, from which 15 candidate genes were screened. Our results provide genomic data for the study of the formation mechanism of the double-petal flower and lay a theoretical foundation for new variety breeding of ornamental pomegranate.
Defining Leadership in Undergraduate Medical Education, Networks, and Instructors: A Scoping Review
Authors: Rodríguez-Feria Pablo , Czabanowska Katarzyna , Babich Suzanne , Rodríguez-Sánchez Daniela , Carreño Hernández Fredy Leonardo , Hernández Flórez Luis Jorge
Published: March 2023

Reviews of the literature on leadership training in undergraduate medical education have been conducted since 2014. Previous reviews have not identified networks, defined leadership, studied the selection criteria for instructors, nor analyzed leadership as interprofessional or transprofessional education. This scoping review fills these gaps. Inclusion criteria included use of competency-based education to teach leadership in universities, and quality assessment. Indexes and grey literature in Spanish, Portuguese, and English languages were included from six databases. Hand searching and consultation were employed for selected bodies of literature. This review identified leadership interventions in nine countries which had national and international networks primarily in English-speaking and European countries. No literature was found in Spanish-speaking or Portuguese-speaking countries, nor in Africa. Teaching leadership was linked mainly with undergraduate medical education and interprofessional education. This review identified 23 leadership and leader definitions and underscored the importance of including values in leadership definitions. Instructors were selected by discipline, role, experience, and expertise. This review may be used to inform the teaching of leadership in undergraduate medical curricula by suggesting potential networks, reflecting on diverse leadership definitions and interprofessional/transprofessional education, and assisting in selection of instructors.
Patient Characteristics in the Recording Courses of Vascular Diseases (Reccord) Registry: Comparison with the Voyager Pad Endovascular Cohort
Authors: Czihal Michael , Malyar Nasser , Stausberg Jürgen , Hoffmann Ulrich
Published: March 2023

Background: To compare the characteristics of a “real world” population included in a prospective registry to patients enrolled in a randomized, controlled trial (RCT) after endovascular revascularization (EVR) for symptomatic peripheral artery disease (PAD). Methods: The RECcording COurses of vasculaR Diseases (RECCORD) registry is an observational registry prospectively recruiting patients undergoing EVR for symptomatic PAD in Germany. VOYAGER PAD was an RCT which demonstrated the superiority of rivaroxaban and aspirin versus aspirin to reduce major cardiac and ischemic limb events following infrainguinal revascularization for symptomatic PAD. For this exploratory analysis, the clinical characteristics of 2.498 patients enrolled in RECCORD and of 4.293 patients from VOYAGER PAD who underwent EVR were compared. Results: The rate of patients aged ≥ 75 years was considerably higher in the registry (37.7 vs. 22.5%). More patients in the registry had undergone previous EVR (50.7 vs. 38.7%) or suffered from critical limb threatening ischemia (24.3 vs. 19.5%). Registry patients were more commonly active smokers (51.8 vs. 33.6%), but less frequently suffered from diabetes mellitus (36.4 vs. 44.7%). While statins (70.5 vs. 81.7%) were less frequently used, antiproliferative catheter technologies (45.6 vs. 31.4%) and postinterventional dual antiplatelet therapy (64.5 vs. 53.6%) were more commonly applied in the registry. Conclusions: There were many similarities but some clinically meaningful differences in clinical characteristics between PAD patients who underwent EVR and were included in a nationwide registry and PAD patients from the VOYAGER PAD trial.
The Development of New Agents for Post-Hematopoietic Stem Cell Transplantation Non-Infectious Complications in Children
Authors: Ilan Uri , Brivio Erica , Algeri Mattia , Balduzzi Adriana , Gonzalez-Vincent Marta , Locatelli Franco , Zwaan Christian Michel , Baruchel Andre , Lindemans Caroline , Bautista Francisco
Published: March 2023

Hematopoietic stem cell transplantation (HSCT) is often the only curative treatment option for patients suffering from various types of malignant diseases and some non-cancerous conditions. Nevertheless, it is associated with a high risk of complications leading to transplant-related mortality and long-term morbidity. An increasing number of therapeutic and prevention strategies have been developed over the last few years to tackle the complications arising in patients receiving an HSCT. These strategies have been mainly carried out in adults and some are now being translated into children. In this manuscript, we review the recent advancements in the development and implementation of treatment options for post-HSCT non-infectious complications in pediatric patients with leukemia and other non-malignant conditions, with a special attention on the new agents available within clinical trials. We focused on the following conditions: graft failure, prevention of relapse and early interventions after detection of minimal residual disease positivity following HSCT in acute lymphoblastic and myeloid leukemia, chronic graft versus host disease, non-infectious pulmonary complications, and complications of endothelial origin.
Fabrication and Experimental Analysis of Bricks Using Recycled Plastics and Bitumen
Authors: Koppula Naveen Kumar , Schuster Jens , Shaik Yousuf Pasha
Published: March 2023

Plastic is being used increasingly in daily life. Most of it is not recyclable, and the remaining plastic cannot be used or decomposed. This causes increased plastic waste, contributing to global warming due to thermal recycling. The major objective of this research was to utilise the maximum plastic waste possible to manufacture bricks that compete with the properties of conventional bricks without affecting the environment and the ecological balance. A balanced mixture of high-density polyethylene (HDPE), quartz sand, and some additive materials, such as bitumen, was used to produce these bricks. Various tests were performed to assess the bricks’ quality, such as compression, water absorption, and efflorescence tests. These bricks had a compression strength of 37.5 MPa, which is exceptionally strong compared to conventional bricks. The efflorescence and water absorption tests showed that the bricks were nearly devoid of alkalis and absorbed almost no water. The obtained bricks were light in weight and cost-effective compared to conventional bricks.
Observation and Modeling of the Equilibrium Slope Response of a High-Energy Meso-Macrotidal Sandy Beach
Authors: Labarthe Carla , Castelle Bruno , Marieu Vincent , Garlan Thierry , Bujan Stéphane
Published: March 2023

Beach slope is a critical parameter to, e.g., beach safety, wave reflection at the coast and longshore transport rate. However, it is usually considered as a time-invariant and profile-average parameter. Here, we apply a state-of-the-art equilibrium model to hindcast beach slope variability from the time scales of days to years at the high-energy meso-macrotidal sandy beach of Truc Vert, southwest France. We use 9 years of bimonthly beach surveys to compute beach slope time series at different elevations. Results show that beach slope exhibits an equilibrium response with contrasting behaviors along two distinct areas of the beach profile. From 0 to 2 m above mean sea level, which is located under the berm crest, a slope response predominantly at the storm time scale is observed. The beach slope steepens under low energy waves, with the equilibrium model explaining up to 40% of the observed beach slope variability. In contrast, from 2.5 to 4 m above mean sea level, which is above the berm crest, the beach slope steepens under high-energy waves. Within this region of the beach profile, the response time scale increases upwards from seasonal (~2.5 m) to seasonal (~4 m), with the model explaining up to 65% of the observed beach slope variability. Such behaviors are found to be enforced by the berm dynamics developing from the end of the winter to early autumn, providing new perspectives to model and predict beach slope on sandy beaches.