bluuebunny/crossref_metadata_2025 huggingface dataset:
Morphological features of a cold skin wound under the influence of an extract of cryopreserved skin fragments of piglets (experimental study)
Authors: Vlasov Oleksandr O. , Kovalov Gennadiy O. , Myroshnychenko Mykhailo S.
Published: October 2020

The aim of the study is to identify in an experiment the effect of an extract of cryopreserved fragments of piglets on the morphological state of a cold skin wound.
Materials and methods: Hairless six-month-old male rats were used in the study. They were divided into III groups: group I included 10 rats that had not been manipulated; group II was represented by 10 rats with cold wounds on the lateral surface of the thigh; group III was represented by 10 rats that were with a cold wound, followed by the injection of an extract of cryopreserved skin fragments of piglets into the abdominal cavity at a dose of 50 μg per 100 g of animal body weight (peptide concentration 100 μg/ ml) once a day for 5 days from the time of wound modeling. Animals in groups I-III were withdrawn from the experiment on the 7th, 14th and 21st days. The material for the morphological study was the fragments of intact skin with underlying soft tissues from the thigh area in group I and the fragments of skin with underlying soft tissues from the thigh area directly from the zone of cryoexposure in groups II and III. Histological, histochemical and morphometric methods were used. Microspecimens were studied using an Olympus BX-41 microscope (Japan). Statistical processing was performed using the Statistica 6.0 and Microsoft Excel 2003 software package. Nonparametric methods were used to compare numerical values (Mann-Whitney U-test, Kruskal-Wallis test). The significance of differences between the average values of the indicators was taken at the level of p<0.05.
Results: The extract of cryopreserved skin fragments of piglets has an effective wound healing effect compared to the healing processes in a cold wound, which was not subjected to any therapeutic effects. It was manifested in the improved process of cleansing the wound from necrotic tissues that entered the zone of primary necrosis, as evidenced by 1,2 times decrease of the zone of primary necrosis on the 7th, 14th and 21st days; a decrease of the zone of secondary necrosis on the 7th, 14th and 21st days, respectively, – 1.2, 1.3, 1.2 times; growth and maturation of granulation tissue activation, as evidenced by an increase in the thickness of a granulation tissue layer on 7, 14, 21 days, respectively, – 1.9, 1.8, 1.2 times; activation of proliferative processes in the epithelial layer located in the marginal sections of the wound defect or covering the regenerate surface, as evidenced by more pronounced acanthotic growths in the underlying tissue and an increase in the thickness of the epithelial layer on the 7th, 14th and 21st days, respectively, – 2.1, 2.0, 2.2 times.
Conclusion: The extract of cryopreserved skin fragments of piglets has an effective wound healing effect and can be recommended for further research in order to study the possibility of its use in clinical practice.
Choosing of drug for anesthesia in intensive therapy of traumatic disease for geriatric patients
Authors: Volkova Yuliya V. , Sharlai Kateryna Yu. , Boiko Olena V. , Dmytriiev Dmytro V. , Dmytriiev Kostaintyn D.
Published: October 2020

The aim of the study was to find the most rational approach to postoperative pain relief in the complex of intensive care for the acute and early periods of traumatic disease in elderly patients. Materials and methods: 132 gerontology patients with multiple trauma were included in the study. Respiratory and cardiovascular systems parameters were assessed, coagulogram and inflammatory response markers, pain severity and analgesia quality were assed. Results: According to the data obtained from the evaluation of VAS and Likerts scale, as well as other results, it was found that the use of NSAIDS and mu-opioid antagonists in the acute and early period of traumatic disease reduces significantly the severity of pain at a minimum daily dose (0.15 mg / kg), decreased the period of anaesthesia on demand, minimized negative respiratory and cardiovascular effects. Presence of sedative effect contributes to the improvement of emotional state of these patients. Conclusions: Age-related changes and concomitant pathology in geriatric patients define the need for the safe pain relief in this patients, in order to decrease possible adverse events. Optimal combination in geriatric patients with perioperative pain syndrome due to polytrauma is NSAIDs with antagonists-agonists. This combination reduce the prevalence and severity of negative respiratory and cardiovascular.
The effect of therapy with olmesartan or telmisartan in patients with arterial hypertension combined with obesity
Authors: Bochar Olesia M. , Sklyarova Helena Y. , Faynyk Andrij F. , Bochar Volodymyr T. , Kuzminov Yurij B. , Bazylevych Andrij Y.
Published: October 2020

The aim: To evaluate the hemodynamic and echocardiographic parameters, the level of adiponectin and IL-6 in such patients under the influence of therapy with sartans (telmisartan or olmesartan) and atorvastatin 12 weeks later
Materials and methods: Fifty patients with arterial hypertension of II stage and 2 level, who underwent elective in-patient treatment were examined. During the next 12 weeks, they took olmesartan (1st group) or telmisartan (2nd group) in combination with atorvastatin.
Results: The combined use of olmesartan or telmisartan in with atorvastatin for 12 weeks had a resulted in a significant decrease in systolic and diastolic blood pressure, heart rate and myocardial mass. After treatment with olmesartan in combination with atorvastatin, the adiponectin content in the blood increased by 41.6% (p <0.05). In the group of patients who receiving telmisartan, an increase adiponectin level was noted in 80.0% of patients and a had shown a significantly higher increase in adiponectin levels, namely for 59.4% after treatment (p <0.01). The level of IL-6 has significantly decreased, both with the administration of olmesartan (2.7 times) and telmisartan (2.6 times) (p<0.01).
Conclusions: Telmisartan, in comparison with olmesartan, significantly reduces the size of the left ventricular and left atrium myocardium, and decreased left ventricular mass index. Telmisartan improves the cardio-metabolic profile of obese and hypertensive patients by increase of adiponectin concentrations and decrease of IL-6 levels.
The impact of systemic inflammation on anemia in patients with chronic obstructive pulmonary disease
Authors: Kovchun Anna V. , Smiianov Vladyslav A. , Kuchma Nataliia G. , Kachkovska Vladyslava V. , Prystupa Lyudmyla N.
Published: October 2020

The aim of our work was to study the indicators of systemic inflammation in patients with chronic obstructive pulmonary disease (COPD) with anemia of chronic disease (AHD).
Materials and methods: The study included 144 COPD patients (1 group) without anemia (hemoglobin> 120 g/l for women and> 130 g/l for men), and 33 patients (2 group) with COPD and ACD (hemoglobin <120 g/l for women and <130 g/l for men, soluble transferrin receptors (sTFR) – 8.7 – 28.1 nmol/l). The control group included 62 practically healthy people. All patients were evaluated for the content of ferritin, C-reactive protein (C-RP) and hepcidin. Statistical processing of the results was performed by using the SPSS-21 program.
Results: Patients with COPD and ACD have a significantly higher ferritin level (p <0.001) compared to COPD patients without anemia and patients in the control group. The content of C-RP and hepcidin in patients with COPD and ACD is also significantly (p <0.001) higher compared to patients without anemia and patients in the control group.
Conclusions: Determination of the content of ferritin, C-RP and hepcidin in patients with COPD may allow adequate treatment for this group of patients.
Checking of the methodical system efficiency of fitness technologies application in students’ physical education
Authors: Zhamardiy Valeriy O. , Shkola Olena M. , Okhrimenko Ivan M. , Strelchenko Oksana G. , Aloshyna Alla I. , Opanasiuk Fyodor H. , Griban Grygoriy P. , Yahodzinskyi Vitalii P. , Mozolev Oleksandr M. , Prontenko Kostiantyn V.
Published: October 2020

The aim is to carry out a comparative analysis of the effectiveness of the traditional system of physical education of students in higher pedagogical education establishments and authors’methodical system of fitness technologies application. Materials and methods: Two hundred thirty two students of Zhytomyr Ivan Franko State University (n=232; 88 males and 144 females) aged from 18 to 20 years old took part in the research. Two experimental groups (EG, 47 males and 71 females) and two control groups (CG, 41 males and 73 females) were formed. Students were offered the following modern types of fitness technologies: power fitness, aerobics, Pilates, swimming, yoga, tae-bo. Results: The positive effect of the authors’ methodical system of fitness technologies application in comparison with the traditional system of physical education has been achieved – according to all the criteria of the research, the indicators of EG students (both males and females) are significantly better than those of the students from CG. Сonclusions: It proves the necessity for the modern fitness technologies application in the educational process of physical education in higher education pedagogical establishments with the aim of improving the state of physical fitness, health of students and increasing their motivation for independent physical exercises and healthy lifestyles in the future.
Association between rankl [RS9594759] and IL10 [RS1800896] Genes polymorphism and deciduous tooth eruption terms in Ukrainians born macrosomic
Authors: Garmash Olga V. , Rossokha Zoia I. , Gorovenko Nataliya G.
Published: October 2020

The aim: The article deals with analyzing the influence of polymorphic variants of CYP19A1 [rs2414096, rs936306], ESR1 [rs2234693, rs9340799], IL1 [rs1143627], IL6 [rs1800796], IL10 [rs1800896] and RANKL [rs959389] genes on deciduous tooth eruption terms in individuals born macrosomic.
Materials and methods: 171 individuals participated in the multi-stage study (144 macosomic-at-birth individuals and 27 normosomic-at-birth persons). This study included only persons who have preserved information about the timing of deciduous tooth eruption – 159 persons (aged from 4 to 55 years), male and female (male / female ratio was 1.5 / 1).
Results and conclusions: The presence of the G allele in CYP19A1 [rs2414096] gene and the -351 A allele in ESR1 [rs9340799] gene were found to be risk factors for fetal macrosomia formation. The research revealed an association of RANKL [rs9594759] gene variants which is a multiplicative model of inheritance and IL-10 [rs1800896], an over-dominant model of inheritance, with an increased risk of tooth delay. Besides the variants of RANKL [rs9594759] and IL-10 [rs1800896] genes a multidirectional modifying effect on the timing of tooth eruption in macrosomic-at-birth individuals made the variant of CYP19A1 [rs2414096] gene – a significant dominant and over-dominant model of inheritance. Further analysis of intergenic interactions will facilitate the application of the obtained results in clinical practice by creating a molecular profile of individuals with deviations in the tooth eruption timing.
Psychosocial aspects of adjustment disorders in women
Authors: Herasymenko Larysa O.
Published: October 2020

The aim is to study the psychosocial aspects of adjustment disorders in women.
Materials and methods: 54 women with diagnosed adjustment disorders (F43.2) who applied for advisory support were examined. The analysis of their anamnestic data with the help of a special questionnaire was performed, a clinical and psychopathological examination was conducted. To study various aspects of psychosocial maladjustment in this contingent of patients “The Stress Scale” by T.H. Holmes and R.H. Rahe (1967), “The Scale of Psychosocial Maladjustment” by L.O. Herasymenko, A. M. Skrypnikov and M. Rokeach methodology of studying of the value orientations (Fantalova O.B. modification, 1992) were used.
Results: In 77.8% of cases a mixed type of maladjustment with dominance in the internal structure of factors of family and industrial maladjustment and in 29.6% a family maladjustment monovariant were identified. In most cases, the family and production variants were combined and a mixed variant of maladjustment was diagnosed. At the same time the most serious forms of maladjustment related to the sexual sphere. Analysis of the structure of psychosocial maladjustment of patients with adjustment disorders showed that the most typical manifestations of this disorder were the following: dissatisfaction with a sense of comfort (75,95 %), dissatisfaction with the psychological climate in the family (62,03 %) and with the period of marriage (62,03 %), dissatisfaction with psychological relationships with colleagues (60,76 %) and with the psychological relationship of the spouse (60,76 %) and a high multiplicity of irritation (54,43 %).
Conclusions: The leading factors of maladjustment among the examined women were the stress in subjectively significant areas of activity and the conflictual nature of the desirability and accessibility of basic life values.
Morphofunctional status of cardio-vascular system of rats with arterial hypertension
Authors: Chuhray Svetlana M. , Lavrynenko Viktoria E. , Kaminsky Rostyslav F. , Dzevulska Iryna V. , Malikov Oleksandr V. , Matkivska Ruzhena M. , Shobat Larysa B. , Kovalchuk Oleksandr I. , Sokurenko Liudmyla M.
Published: October 2020

The aim: Was to clarify the general patterns of structural changes in the left ventricular myocardial capillaries in rats with spontaneous arterial hypertension. Materials and methods: Experiments were conducted on 50 ISIAH (inherited stress-induced arterial hypertension) line rats with arterial hypertension: juvenile young (45-day) and sexually mature (100-day) rats, as well as intact animals of the corresponding age. While extracted from the experiment rats of all experimental groups had their arterial pressure measured using a plethysmograph. Electron microscopic examination of the left ventricular myocardium and morphometric study of volumetric and quantitative densities, cross-section area, and form factor of micropinocytotic vesicles were conducted. Results: In sexually mature rats with arterial hypertension, a high level of pressure is maintained. In 45-day-old rats with arterial hypertension in endothelial cells of myocardial blood capillaries there is a hyperactivation of biosynthetic processes (euchromatic nucleus, large-sized mitochondria, ER canals, Golgi complex), which may be a manifestation of reactive processes in response to a non-stable increase in arterial pressure. In the 100-day rats with arterial hypertension, the mosaic of the ultrastructure of the myocardium blood vessels is preserved, but destructively-dystrophic changes become more expressive and involve not only the organelles but also the integrity of the endothelial cell itself. Destructively-dystrophic processes in rat capillaries are accompanied by compensatory and adaptive ones. This is manifested by activation of the transport of substances, both transendothelial and paracellular, and quantitative density of micropinocytotic vesicles increases statistically significantly. Conclusions: In myocardial capillaries of young (45-day) arterial hypertension rats, compensatory and adaptive changes are manifested by activation of biosynthetic processes in endothelial cells following a slight increase in micropinocytotic vesicles quantitative density and signs of destructive-dystrophic processes (minor edema and lysis of endothelial cell cytoplasm). In sexually mature (100-day) arterial hypertension rats in the blood capillaries of the myocardium, the destructive-degenerative changes increase is accompanied by preservation of signs of compensatory processes. Reducing the number of capillaries is offset by an increase in the number of micropinocytotic vesicles.
Statistical analysis of the сhronic gastritis in students
Authors: Kharchenko Aleksandr V. , Kharchenko Nataliya V. , Makarenko Petro M. , Sakharova Lyudmyla M. , Khomenko Pavlo V. , Kvak Olga V.
Published: October 2020

The aim: The aim of the study is a statistical analysis of the mucosa of the stomach affected by Helicobacter pylori in young people studying at the university.
Materials and methods: The work contains the results of the study of chronic gastritis of type B in university volunteer students. The study was attended by students of 1-4 courses, aged 17 to 25 years, a total of 50 people. Among them were 28 men and 22 women.
Results: Various forms of chronic gastritis were found in the mucosa of the topographic-anatomical sections of the stomach, 90% of which were associated with Helicobacter pylori (HP). In all departments there is a different amount of common forms of chronic gastritis. In the pyloric section only atrophic gastritis was detected – 31.0 ± 8.5. Atrophic gastritis was also dominant on the lesser curvature – 32.3 ± 7.8, but its forms were significantly (p <0.5) less pronounced than in the pyloric section. In the area of the body, the above variants of chronic gastritis were found in 34.3 ± 8.7 cases, and the majority were flat erosive gastritis 51.0 ± 9.3.
There is a tendency to reduce the degree of bacterial contamination of the gastric mucosa from its pyloric section and the lesser curvature to the walls of the body. With a decrease in the degree of bacterial contamination of the gastric mucosa, the degree of leukocyte infiltration also decreases.
Between the degree of contamination of the mucous membrane of Helicobacter pylori and the degree of leukocyte infiltration of the mucous membrane, the Pearson correlation coefficient is rxy – 0,935, the correlation is very strong, the coefficient of determination is D=rxy^2 – 0,874, the statistically significant dependence on the probability is 0.99.
Conclusions: Atrophic or hyperplastic gastritis associated with HP is found in the gastric mucosa, respectively, 90% of cases. The degree of bacterial contamination correlates with the degree of leukocyte infiltration of the gastric mucosa. Atrophic or hyperplastic gastritis Helicobacter pylori-associated is a common disease of people in young and working age.
Emotional distress and quality of life in allergic diseases
Authors: Jarosz Marcin , Syed Sadia , Błachut Michał , Badura Brzoza Karina
Published: October 2020

Emotional disorders accompany many somatic diseases, especially ones with severe or chronic course, and such are allergic diseases. Long-term course of the disease, the need for chronic treatment and repeated exacerbations as well as symptoms of depression or anxiety have a significant impact on the quality of life of patients, constituting a serious burden both from the point of view of the individual and the society. The data evaluating emotional disturbances and their impact on the quality of life in three atopic diseases: bronchial asthma, atopic dermatitis and seasonal rhinitis were analysed. Mood disorders as well as mental and behavioral disorders due to alcohol abuse are the most common psychiatric disorders observed in patients with bronchial asthma. There are data indicating a relationship between the occurrence of allergic rhinitis and mood disorders, anxiety disorders and suicidal tendencies. Atopic dermatitis is associated with an increased risk of depressive and anxiety disorders and sleep disorders, and in children with more prevalence of behavioral disorders. Most studies highlighted the relationship between emotional disorders and quality of life in the above-mentioned patient groups. In addition to physical ailments, patients suffering from allergic diseases also report emotional problems that can adversely affect the course of the disease, the treatment process, and reduce quality of life. Therefore, these patients require a holistic approach with a more accurate assessment of emotional disorders.
Protozoan genital invasions caused by the representatives of trichomonas and giardia
Authors: Fedorych Pavlo V. , Mavrov Gennadiy I. , Osinska Tetiana V. , Shcherbakova Yuliia V.
Published: October 2020

The aim was to perform systematic review of genitourinary protozoan invasion and analyze their pathogenicity and the ability to influence the genitourinary infections.
Materials and methods: For systematic review of papers the EMBASE and PubMed databases were searched. We also reviewed our own pilot studies using real-time polymerase chain reaction (PCR) to determine Trichomonas tenax, Pentatrichomonas hominis and Giardia lamblia.
Conclusions: Trichomonas tenax, Pentatrichomonas hominis, Giardia lamblia can cause genitourinary invasion in addition to Trichomonas vaginalis. Their eradication is obligatory at least for not keeping intact pathogenic microorganisms phagocyted by Trichomonas spp. Defining the protozoan forms is important in preventing of genital infections recurrences and reinfections.
TLR expression on peripheral blood monocytes in patients with psoriasis
Authors: Pochernina Valeriia V. , Daschuk Andrey M.
Published: October 2020

Toll-like receptors (TLRs) are signalling pattern-recognition receptors, which play an important part in initiating the immune response in psoriasis. The available literature has little information about study of these receptors in blood. The purpose of the present work was to study the level of expression of TLR2 and TLR4 types on blood monocytes in a psoriasis patient. Within 2016-2018, TLR2 and TLR4 were examined thrice in the blood of a patient with psoriasis during its exacerbation before the beginning of his treatment. The expression of surface receptors CD282 (TLR2) and CD284 (TLR4) on peripheral blood monocytes was studied by the method of flow cytometry with use of monoclonal antibodies. The obtained data show that the expression of TLR2 on peripheral blood monocytes was high, while that of TLR4 was mostly within its reference values of 3.3±0.1 mfi. Hence, the conducted studies have shown that the expression of TLR2 on peripheral blood monocytes in all three studies was high, thereby demonstrating involvement of this factor into the pathogenesis of the above disease. During all three blood examinations, monocytes revealed an extremely high intensity of TLR2 fluorescence on studied cells that exceeded the same intensity in healthy subjects by 1.5-2 times. The expression of TLR4 on peripheral blood monocytes during all three studies was within its reference values, this fact demonstrating absence of any information value of the above factor in the pathogenesis of psoriasis.
COMPARISON OF THE EFFECTS OF TOFACITINIB AND
ADALIMUMAB ON TRANSCOLONOSCOPIC PH AND
CALPROTECTIN LEVELS IN PATIENTS WITH ULCERATIVE COLITIS
Authors: Varvarynets Antonina V. , Chubirko Ksenija I. , Chopey Ivan V. , Hnepa Yana Y. , Kurakh Artur V.
Published: October 2020

The aim: To investigate the transcolonoscopic pH-metry and calprotectin in patients with ulcerative colitis.
Materials and methods: the research included 110 patients both male and female between the ages of 18 to 75 years old, who were treated for UC of medium and severe
activity, in active phase. All patients were divided into 3 groups. The first group received standard therapy (ST; n=50), the second group received adalimumab (ADA; n=32), and
the third group was treated with tofacitinib (TOF; n=28). The control group consisted of healthy individuals between the ages of 18 and 65 years old.
Results: UC patients had lower pH levels in all sections of the large intestine, compared to the control group (р<0,05). Calprotectin level is a better predictor of the course of
the disease.
Conclusions:Tofacitinib, compared to adalimumab and budesonide, has better influence on clinical, endoscopic and laboratory parameters of UC.
A RESPONSIBLE PATIENT: FROM THEORY TO PRACTICE ON A MODEL OF A PATIENT WITH BRONCHIAL ASTHMA
Authors: Velychko Valentyna I. , Venher Yaroslava I. , Lahoda Daria O.
Published: October 2020

Introduction: The medicine of today is focused on personalized aid to a patient, which involves partnership and mutual responsibility between the patient and the doctor. In
our reality, the patient believes that the responsibility for the treatment and outcome depends on the doctor in most cases.
The aim: Induce the patient to develop responsibility for the course of asthma against the background of EBW or obesity and introducing this program into the practice of
family physicians.
Materials and methods: By design, the study included 75 patients with asthma with varying degrees of severity, persistent course in the remission stage against the background
of EBW or obesity. According to the randomization method, the patients were divided into 3 groups: the main group – 30 patients (the use of medication), the comparison
group – 30 patients (training in the “Asthma School”), the 3rd group was controls of 15 patients (basic therapy).
Results: According to the anthropometric study, 75 patients enrolled in the study were found to have EBW or obesity and the mean BMI was 31.67 ± 0.53 kg / m2. It was also
found that 20 (66.67%) patients in the main group and 21 (70.00%) patients in the comparison group did not regularly use basic therapy and cancelled or changed the drugs
without permission. After the training, 45 patients (76.66%) of the total patients of the main group and the comparison group began to perform respiratory movements with
the inhalation device correctly. patients in the main group reduced body weight on an average by 4.5 kg, and BMI from 32.00 kg / m2 changed to 29.7 kg / m2 (p <0.05), although
they did not reach 25.0 kg / m2 of the target level because the follow-up period was not long.
Conclusion: Only patients in the main group had significant positive changes in asthma control, the patients in the comparison group also had positive dynamics, but it did
not show statistically significant differences. The doctor should be interested in the fact that at the first and subsequent visits regarding the disease, in our case it is bronchial
asthma, the patient will feel responsible for the disease. Therefore, when communicating with the patient, the physician should focus on this, provide the most complete answers
to the patient’s questions, provide educational literature and, if necessary, diaries of self-control.
COMORBIDITY IN PATIENTS WITH CHRONIC CORONARY SYNDROMES: PREVALENCE AND ASSESSMENT
Authors: Moroz Galina Z. , Hidzynska Irina M. , Kravchenko Anatoly M. , Lasytsia Tatyana S. , Dzіzinska Olena O.
Published: October 2020

The aim: To carry out an evaluation of comorbidities in CCS patients having undergone PCI for stable coronary artery diseases (planned) or PCI in myocardial infarction (urgent)
with the aim of justifying the best management strategies.
Materials and methods: We carried out an analysis of comorbid pathology spreading and the evaluation of multiple comorbidities using of Combined Age Charlson Comorbidity
Index (CA-CCI) – in 138 patients below 75 yrs having undergone urgent and planned PCI. These patients were divided into two groups; the Ist one included 60 patients with
urgent PCI (angioplasty with stent), the 2nd group – 78 patients with planned PCI.
Results: We found a high prevalence of comorbidity in CCS patients: the mean number of diseases in patients of the 1st and 2nd groups were 8.2±0.3 and 9.3±0.4, and the CACCI
values – 7.3±0.3 and 7.5±0.2, respectively (p>0.05). Ten and more diseases were found in (28.3±5.8%) patients from the 1st group and in (43.6±5.6%) patients from the
2nd group (p=0.06). The most frequent comorbidities were arterial hypertension, cerebrovascular diseases, peripheral arterial disease, type 2 diabetes mellitus, and impaired
glucose metabolism.
Conclusions: Comprehensive assessment and management of patients with CCS who undergo PCI remains a current problem in modern medicine, given the high prevalence
of comorbid pathology.
INVESTIGATION OF THE INFLUENCE OF THROMBOPHILIC
GENES POLYMORPHISM, INCLUDING SERPIN 1 (PAI-I), FII, PROTHROMBIN AND ITGB3-Β INTEGRIN, ON THE FREQUENCY OF STROKE IN ASSOCIATION WITH CONTROLLABLE RISK FACTORS FOR ITS OCCURRENCE
Authors: Oros Mikhail M. , Lutz Vitaly V. , Pavlo Andrukh H. , Sitkar Andrii D.
Published: October 2020

The aim is the analysis of the relationship between the polymorphism of thrombophilic genes, in particular Serpin 1 (PAI-1), F2-prothrombin and ITGB3-β integrin, and the
incidence of stroke, as well as the study of factor effects of this polymorphism in association with controlled risk factors (hypertonic disease, smoking, alcohol consumption,
diabetes mellitus, obesity, atrial fibrillation).
Materials and methods: A total of 134 patients were examined (men accounted for 44.8%, women 55.2%, average age 62.5 ± 2.1). The statistical analysis was carried out
using the following criteria: χ2-Pearson, Fisher’s exact criterion (reversible), Chuprov’s coefficient of conjugation and dispersion analysis (alternative complex).
Results: The relationship between the frequency of a specific allele of thrombophilia and the incidence of stroke is absent. The reason for such results can be a significant effect
of random factors (hypertension, diabetes ...), a significant variability of risk factors, their different frequency in groups (inter- and intra-group differences), a significant (95%)
total effect of these factors.
Conclusions:Identification of biochemical or genetic markers of thrombophilic conditions, including polymorphism of the hemostasis system genes, will significantly increase
the possibility of adequate pathogenetic treatment and timely prevention of acute cerebrovascular disorders, especially persons of working age, which has great medical and
social importance.
DIAPHRAGMATIC BREATHING IN BIOLOGICAL FEEDBACK MODE FOR CORRECTION OF THE PSYCHOPHYSIOLOGICAL STATE IN MEDICAL STUDENTS
Authors: Palamarchuk Olga S. , Slyvka Yaroslava I. , Savka Yulianna M. , Feketa Volodymyr P.
Published: October 2020

The aim: The current study aimed to examine the possibility of correction of the psychophysiological state of the undergraduate students by diaphragmatic breathing sessions in the biological feedback mode utilizing heart rate variability. Materials and methods: The study enrolled 86 students 18 to 20 years old. Assessment of the functional state of the ANS was performed bycardiointervalography (CIG) and analysis of the spectral indices of HRV by the hardware-software complex “Cardiolab” (КAI Medica, Ukraine). A complex assessment of the autonomic homeostasis was performed using IARS calculated by a special algorithm. Assessment of the psychophysiological state of students was performed by questionnaires. Results: Among the examined population, 45% of students were in the state of satisfactory adaptation, 43% – in the state of functional tension, and 12% – in the state of unsatisfactory adaptation. Students with poor level of adaptation and depletion of regulatory mechanisms had higher heart rate, systolic and diastolic pressure, and RR compared to the students in the state of satisfactory and strained adaptation. Conclusions: The findings suggest that the average intensity of psychosomatic complaints has significant differences between groups with varying degrees of tension of regulatory mechanisms.
CLINICAL SYNDROMES OF THE THALAMIC STROKE
IN THE CLASSICAL VASCULAR TERRITORIES:
A PROSPECTIVE HOSPITAL-BASED COHORT STUDY
Authors: Prokopiv Maria M. , Fartushna Olena Y.
Published: October 2020

The aim: We aimed to determine, describe, and analyze the clinical and neuroimaging features of vascular syndromes of acute thalamic stroke in the classical vascular territories
in a prospective hospital-based cohort study.
Materials and methods: We have prospectively recruited 319 acute stroke patients, admitted to the Neurological Center at an academic hospital (Oleksandrivska Clinical
Hospital) in Kyiv, Ukraine. Complex neurological, clinical, laboratory, ultrasound, and neuroimaging examinations were performed to all study patients within 24 hours since
the symptoms onset.
Results: MRI/CT-proven thalamic stroke was diagnosed in 34 (10.6%) out of 319 patients, forming a study group. Twenty-two out of 34 patients (average age 61.9 ± 10.2
years) were diagnosed with an acute isolated ischemic thalamic stroke, and 12 patients (average age 59.0 ± 9.6 years) were diagnosed with an acute thalamic hemorrhage.
Conclusions: Specific neurological features of clinical vascular syndromes of acute thalamic stroke in the classical vascular territories were analyzed, compared, and described.
COMPLEX PROGRAM OF DIAGNOSTICS AND TREATMENT OF POLYTRAUMATIZED PATIENTS WITH II-III DEGREES OBESITY
Authors: Chemerys Orest M. , Katelian Olena V. , Khimich Sergii D. , Stoianovskyi Igor V.
Published: October 2020

The aim: Elaboration of the complex program of diagnostics and treatment of the polytraumatized overweight patients.
Materials and methods: Clinical material was composed of 64 patients with the combined body trauma who suffered from II-III grade obesity.
Results: Main principles of rendering the aid to the polytraumatized overweight patients included the pathophysiological and topographic features of the group. The obtained
study results confirmed the credible difference of the traumatic disease progress in the patients with the normal weight and overweight patients which was the basis of our
differential complex treatment program.
The treatment tactics also had certain characteristics connected with the obesity. The development of RDS syndrome is a typical stage of the traumatic disease during the blunt
thoracal trauma in case of obesity. The programmed and urgent relaparotomy, as a method of the stage treatment in the present group of patients, is the integral component
of the blunt abdominal injury in case of obesity.
Conclusions: The study results proved that our complex program of diagnostics and treatment of the polytraumatized patients shall be basic for the patients with II-III grade obesity.
THE ROLE OF CYTOCIN IMBALANCE IN THE DEVELOPMENT
OF MAN INFERTILITY
Authors: Babinets Liliia S. , Migenko Bogdan O. , Borovyk Iryna O. , Halabitska Iryna M. , Lobanets Nataliia V. , Onyskiv Orest O.
Published: October 2020

The aim: Study of the clinical and pathogenetic role of IL-17, IL-35 and their correlation in the development of infertility in men with chronic ureoprostatitis.
Materials and methods: 82 male aged 20 to 40 were examined. The patients were divided into three groups: the first – 10 practically healthy men, in which the levels of IL-17
and IL-35 in semen were taken as normal; second – 33 infertile men with chronic urethroprostatitis; third – 39 fertile men with chronic urethroprostatitis.
In addition to conventional clinical and laboratory (clinical blood and urine tests) studies, all men in semen were tested for IL-17 and IL-35 cytokine levels.
Results: The levels of the studied cytokines were found to have opposite tendencies to shifts in the semen of men with chronic urethroprostatitis. The level of IL-17 in sperm
increases and the level of IL-35 decreases. The IL-17/IL-35 index increases more strongly in men with impaired fertility.
Conclusions: Increas IL-17 concentrations, decreas IL-35 levels and increas their correlation may be an indicator of infertility in men with chronic ureoprostatitis. Determining
the IL-17 / IL-35 correlation in general clinical practice will allow to single out a group of men with a high likelihood of developing infertility for follow-up and treatment by a
doctor of family medicine.
BONE MINERAL DENSITY AND TRABECULAR BONE SCORE IN POSTMENOPAUSAL WOMEN WITH KNEE OSTEOARTHRITIS AND OBESITY
Authors: Povoroznyuk Vladyslav V. , Zaverukha Nataliia V. , Musiienko Anna S.
Published: October 2020

The aim of the study was to investigate the relationship between bone mineral density (BMD) of lumbar spine, femoral neck, trabecular bone score (TBS) and body mass index
(BMI), in postmenopausal women with knee osteoarthritis (OA).
Materials and methods: The study group comprised 359 postmenopausal women aged 50-89 years. They were divided into 2 groups: I group – 117 postmenopausal women
with symptomatic knee OA and II group –242 women with a normal functional activity of knee joints. Analysis of data was performed taking into account their BMD of lumbar
spine (L1-L4) and femoral neck, measured by the Dual-energy X-ray absorptiometry (DXA) Hologic (Discovery WI, USA, 2016). TBS of L1-L4 was detected by TBS insight® software
(MedImaps, Pessac, France), and BMI classified by World Health Organization (WHO).
Results: In postmenopausal women with obesity prevalence of symptomatic knee OA was detected in 41.1% of cases. However, in women with normal BMI knee OA was
revealed in 29.0% of women. The highest level of knee OA in obese women aged 70-79 years – 45.8%. According to a chi-squared (χ2) test, a significantly higher level of BMI
was detected in postmenopausal women with OA (χ2=5.05, p=0.02).
Conclusion: Women with a symptomatic OA had a significantly higher BMD of lumbar spine compared with women who had a normal functional activity of knee. Significant
negative correlation were detected between TBS and BMI, and significant positive correlations between lumbar spine BMD and BMI.
THE ROLE OF PHYSICAL EDUCATION IN IMPROVING THE HEALTH STATUS OF STUDENTS OF SPECIAL MEDICAL GROUPS
Authors: Griban Grygoriy P. , Tymoshenko Oleksii V. , Arefiev Valery G. , Sushchenko Lyudmyla P. , Domina Zhanna G. , Malechko Tetiana A. , Zhuravlov Iurii G. , Tkachenko Pavlo P. , Baldetskiy Andriy A. , Prontenko Kostiantyn V.
Published: October 2020

The aim is to carry out the analysis of the disease incidence of students and to scientifically substantiate the directions of improving health and fitness activity in the physical education of the students of special medical groups. Materials and methods: The study was conducted at Zhytomyr National Agroecological University in 1992-2019. The main pedagogical experiment involved 681 students (209 males and 472 females, aged 17-22). The research methods included theoretical methods (the analysis and synthesis of literary sources, the analysis of curricula, the assessment of the quality of classes with the students of special medical groups, the study and analysis of the medical cards of students); empirical methods (pedagogical observations, the methods of mathematical statistics). Results: The study determined that more than 57.6 % students of higher educational establishments of Ukraine had an unsatisfactory level of physical fitness, significant physical disabilities, diseases; from 10.9 to 20.5 % students had an insufficient level of physical fitness and significant health disorders; from 8.1 to 17.4 % students belonged to a special medical group; from 0.4 to 1.2 % students were exempt from sports and had chronic diseases and disabilities. Conclusions: The quality of the physical education process in special medical groups depends on the interconnection of all the components that affect its efficiency, including an outlook, motives, interests, the attitude of students to physical education and health-improving activities; the students’ desire to overcome their health disabilities; individual characteristics of students; the means, forms, methods, and principles of physical self-improvement; material and technical support of educational and health and fitness events.
IMPACT OF DIFFERENT ANGIOTENSIN-CONVERTING INHIBITORS ON OUTCOMES OF POST-MYOCARDIAL INFARCTION PATIENTS
Authors: Hrebenyk Marian V. , Bidovanets Larysa Yu.
Published: October 2020

The aim: To compare the long-term effects of different angiotensin-converting enzyme inhibitors in post-myocardial infarction (MI) patients.
Materials and methods: Of 445 consecutive patients with myocardial infarction, 76 (17%) patients had co-morbid conditions, as well as were found to be compliant with
secondary prevention treatment and eligible for follow-up. These patients were assigned to ramipril, perindopril or zofenopril groups in complex management of post-MI period.
Subsequently, the patients were followed-up prospectively for a period of up to 24 months.
Results: Patients of zofenopril group performed better in terms of post-MI biventricular remodeling and left ventricular function recovery. Also, patients receiving zofenopril
showed benefits in terms of short-term and long-term mortality as compared with patients of ramipril and perindopril groups.
Conclusion: Zofenopril may have advantages over perindopril and ramipril in the complex management of post-MI patients in terms of prevention of negative myocardial
remodeling, onset of congestive heart failure and major adverse events.
THE HISTOTOPOGRAPHIC FEATURES OF FORMATION OF KELOID SCARS OF MAXILLOFACIAL LOCALIZATION
Authors: Lokes Kateryna P. , Avetikov David S. , Klitynska Oksana V. , Brekhlichuk Pavlo P. , Bun Yana I.
Published: October 2020

The aim: Study of the influence of local oxygen deficiency on the features of the formation of keloid scars of the head and neck. Materials and methods: The research material was 17 incisional biopsy specimens of keloid scars, which were the highest age categories of patients from 19 to 63 years. Results: It was revealed that at coloring according to Mallory’s technique, sections of fibrinoid swelling of collagen fibers were noted near central homogeneous hyaline masses. The lateral areas of the dermis that adjacent to keloid scar tissue, at coloring by the Hart method, in our modification, were characterized by the separation of the hyalinosis zone from the undamaged dermis by coarse bundles of elastic fibers that are colored in dark purple. The undifferentiated dysplasia of the connective tissue has caused the replacement and obstruction of single vascular components, which has complicated the local oxygen deficiency of keloid-altered tissues. Conclusions: Thus, plasmaragia and the accumulation of protein deposits in the perivascular space determine the inhibition of local hemodynamics, which explains the decrease in oxygen transport to tissues. Decreased oxygenation and increased permeability of the vascular wall causes local hemocirculatory hypoxia.
INDICATORS OF INFLAMMATION IN THE PATHOGENESIS OF UNSTABLE ANGINA
Authors: Zaremba Yevheniia H. , Smaliukh Olha V. , Zaremba-Fedchyshyn Olena V. , Zaremba Olha V. , Kost Andriy S. , Lapovets Lyubov Ye. , Tomkiv Zoriana V. , Holyk Oksana M.
Published: October 2020

The aim: Research of blood lipid spectrum, level of anti-inflammatory cytokines and C-reactive protein of coronary heart disease patients. Materials and methods: There was examined 61 patients with unstable angina, who had been on hospital care in the cardiology department of the Lviv National Emergency Hospital. Their average age was 68.3 ± 1.9 years. The control group included 20 generally healthy persons. There was estimated blood lipid spectrum, C-reactive protein, fibrinogen and proinflammatory cytokine of patients. Results: There was determined considerable increase total cholesterol, low density lipoprotein cholesterol, very low density lipoprotein cholesterol, triglycerides and coefficient of atherogenicity. High level of C-reactive protein and pro-inflammatory cytokines were detected in patients with unstable angina. Conclusions: In patients with unstable angina was revealed a significant increase of proinflammatory cytokines levels in the blood serum: interleukin-1β, interleukin-6, interleukin-17, TNF-α and C-reactive protein, fibrinogen, which indicates activation of the inflammatory process. In patients with unstable angina was detected a significant disorder of blood lipid spectrum. For its correction should be recommended diet and hypolipidemic agents.
PERINATAL AND INFANT MORTALITY IN THE TRANSCARPATHIAN REGION AND UKRAINE AGAINST THE BACKGROUND OF THE EUROPEAN UNION AND THE WORLD: A COMPARATIVE ANALYSIS AND POSSIBLE PROBLEMS
Authors: Rogach Ivan M. , Slabkiy Gennady O. , Pogorilyak Renata Y. , Keretsman Angelika O. , Gadzhega Ivan I.
Published: October 2020

The aim of this article was to analyze the dynamics of perinatal mortality and mortality up to 1 year in the Transcarpathian region and Ukraine in comparison with other
countries of Europe and the world.
Materials and methods: The study is based on data from the Transcarpathian Regional Medical Information and Analytical Center, the Center for Medical Statistics of the
Ministry of Health of Ukraine, the European database «Health for All» and the Center for Research of Health Services at the University of Kent, Kiev Economic Institute of the
Kiev School of Economics (July 2017).
Review: In 2016, mortality under the age of 1 year in Ukraine amounted to 7.4 per 1000 live births, which is 13.5% lower than the same indicator in 2012 (8.4). According to
perinatal mortality, in Ukraine this indicator has a level of 8.59 ‰, while the average in the EU countries does not exceed 6.01 ‰.
Conclusions: Perinatal and mortality rates up to 1 year in the Transcarpathian region, as in Ukraine as a whole, are an order of magnitude higher than the European average.
The same negative trend in the survival of newborns in Transcarpathia and in Ukraine.
COMPARATIVE EVALUATION OF THE RESULTS OF SURGICAL TREATMENT OF ACUTE ASCENDING THROMBOPHLEBITIS OF THE GREAT SAPHENOUS VEIN USING THE ENDOVASCULAR HIGH-FREQUENCY WELDING TECHNIQUE AND TRADITIONAL TECHNIQUE
Authors: Savolyuk Serhiy I. , Khodos Valentyn A. , Herashchenko Roman A. , Horbovets Vladyslav S.
Published: October 2020

The aim of the study was to conduct a comparative evaluation of the effectiveness of surgical treatment of acute ascending thrombophlebitis of the great saphenous vein using the endovascular high-frequency welding technique and traditional phlebectomy. Materials and methods: Two groups were formed in the conducted study. Group I included patients (n=42) with the acute ascending thrombophlebitis of the great saphenous vein, in whom their thrombosed great saphenous vein was removed using the endovascular high-frequency welding technique. As a source of current, an EK300M1 Svarmed electric welding machine (Ukraine) was used. Electric welding of a thrombosed vein segment was carried out using the endovenous electric welding catheter. Group II included patients (n=31) with the acute ascending thrombophlebitis of the great saphenous vein, who underwent the traditional phlebectomy of the thrombosed great saphenous vein according to Babcock’s technique.
Results: In group I no patient revealed presence of pain syndrome with significant intensity during the postoperative period. An infiltrate along the coagulated segments of the great saphenous vein, postoperative oedema and paresthesiae were observed in considerably fewer cases from group I versus group II (р=0.0005, р=0.0001, р=0.0018). During their follow-up for more than 12 months, 2 (4.76 %) of 42 patients from group I revealed partial recanalization of the great saphenous vein (р=0.632). In group I the postoperative inpatient period was 1.3±0.1 days. In group II the above period averaged 4.8±0.8 days (p<0.001). Absence of an intense pain syndrome in group I was caused by a gentle effect of high-frequency electric current itself on the venous wall and paravasal structures. A significant reduction of side effects and complications with a shorter stay of patients in hospital versus the traditional phlebectomy was achieved owing to reduction in the extent of injury of the surgical operation itself with the use of endovascular high-frequency welding.
Conclusions: The technique of endovascular high-frequency welding in treatment of acute ascending thrombophlebitis of the great saphenous vein makes it possible to reduce the extent of injury of the surgical operation versus the traditional phlebectomy, results in a significant decrease in the number of side effects and complications and shortens the period of the patient’s stay in hospital.