bluuebunny/crossref_metadata_2025 huggingface dataset:
La tasa de descuento en el proceso de valoración de empresas: un estudio empírico en Colombia
Authors: Rojo-Ramírez Alfonso , Palomino Rubio César Augusto , García Pérez de Lema Domingo , González Benítez José Domingo , Mayorga Sanchez Jose Zacarias , Alba Suárez Miguel Antonio
Published: January 2019

Firms' valuation is an increasingly important activity in a globalized context with more dynamic and internationalized companies in search of value creation. Internationalization is increasingly affecting developing countries that are forced to deal with international M&A and the requirements of their increasingly specialized partners, such as is the case of Colombia. Normally, the use of ad-hoc update rates is required in the process. The main goal of this work is to increase our knoledge ion the use of the discount rate in the business valuation activity in Colombia. For this purpose, an exploratory study based on a survey of 32 Colombian experts in business valuation is included. Our main conclusions reveal that Colombian experts behave similarly to international valuers, although there is a large dispersion in the estimation of the discount rate. In this way, the research carried out can be of interest not only for professionals but also for academics and managers who participate in this process to offer information about the Colombian reality in an international context
Análisis de las relaciones entre los tipos de innovaciones y el desempeño empresarial en parques tecnológicos
Authors: Roldan Lucas Bonacina , Bastos William Neves
Published: January 2019

The need for companies to always innovate to stay competitive makes them invest in innovations. The impact of these innovations between them and the performance of innovations needs to be better explored and understood. This article analyzes the relationship between innovation types and performance in Brazilian technology parks. To reach the objective, a survey was conducted with 231 companies resident in the Brazilian technology parks and the analysis of the data obtained was done through the modeling of structural equations. As a result, it was identified that organizational innovations influence process and marketing innovations, process innovations influence product innovation and organizational performance, and marketing innovation influences organizational performance
Самоорганизация полиядерных комплексов на основе спейсерированных пиридилазолов
Authors: Гусев А.Н. , Шульгин В.Ф. , Кискин М.А.
Published: January 2019

Проанализированы литературные данные о структурных особенностях координационных соединений на основе спейсерированных пиридилазолов (пиразолы, 1,2,4- и 1,2,3-триазолы, тетразолы). Показано, что реализация принципа MSO — "maximum site occupancy" при соотношении металл:лиганд = 2:3 приводит к самоорганизации полиядерных кластеров с геометрией металлоостова в виде высокосимметричных архитектур, таких как тетраэдр, тригональная призма, куб, усеченный тетраэдр и кубооктаэдр.
Агрегация катионных производных хлорина е6 в воде и водных растворах поливинилпирролидона
Authors: Батов Д.В. , Кустов А.В. , Кручин C.О. , Макаров В.В. , Березин Д.Б.
Published: January 2019

Методами динамического светорассеяния и электронной спектроскопии поглощения изучены процессы агрегации и дезагрегации моно-, ди- и трикатионного хлоринов (соединения I—III) как потенциальных фотосенсибилизаторов (ФС) для фотодинамической терапии (ФДТ) в воде и водных растворах поливинилпирролидона (ПВП), определен средний размер частиц и характер их распределения. Образование наноагрегатов соединений I—III фиксируется при СФС в интервале 0.7—1.2 ммоль/кг, причем размер частиц увеличивается при хранении раствора. Распределение частиц дисперсной фазы по размерам имеет мономодальный характер только для ФС с более высокой растворимостью в воде. Минимальные добавки ПВП приводят к разрушению крупных (200—300 нм) агрегатов ФС; при этом, согласно спектрам поглощения, агрегаты небольшого размера не разрушаются полностью даже при 100-кратном мольном избытке полимерного ПАВ.
Structure of a one-dimensional copper(I) polymer with iodine bridges
Authors: Aguirrechu-Comerón A. , Hernández-Molina R. , González-Platas J.
Published: January 2019

A novel one-dimensional polymeric Cu(I) halide complex with iodine bridges between copper atoms and 2-phenylquinoline as an N-donor ligand is prepared. The complex is characterized by elemental analyses, IR spectroscopy, and crystallographic studies.The coordination geometry around copper may be described as distorted trigonal planar. The I—Cu—I, Cu—I—Cu, and N—Cu—I angles are 115.90(2), 116.37(2), and 124.80(8)°, respectively. The Cu—I distances range from 2.563(6) to 2.569(6) Å, and the Cu—N bond is 2.016(2) Å, being in good agreement with that in the related structures.
Benedek László ideggyógyász-professzor, a debreceni m. kir. Tisza István-Tudományegyetem 1935–36. tanévi rector magnificusa
Authors: Mudrák József
Published: January 2019

László Benedek Professor of the Neurology, the Rector Magnificus of the Hungarian Royal István Tisza University of Debrecen during the academic year 1935/1936. The first professor of neurology and psychiatry and the director of the Department of Neurology of the University of Debrecen between 1921 and 1936 was László Benedek who studied at Cluj as a student of Károly Lechner. In the academic year of 1935/36 he held the post of the Rector of the university. This period was the era of silent development in the life of the university. Benedek as Rector focused on improving the living circumstances of the students. After his rectorate he was appointed to a professorship of the Péter Pázmány University of Arts and Sciences and the director of the Clinic of Neurology and Psychiatry in Budapest. His wife was the wellknown actress Irén Zilahy. After her tragic death in April 1944 Benedek collapsed and in March 1945 he committed suicide in Kitzbühel in Austria. László Benedek was a brilliant lecturer, an urging leader, and an inventive professor of science whose work in several partial branches of science was outstanding.
Pápai Páriz Ferenc: A gyulafehérvár–nagyenyedi Bethlen-kollégium alapítása és története
Authors: Ősz Előd
Published: January 2019

A gyulafehérvár–nagyenyedi Bethlen-kollégium alapítása és története című könyv recenziója
La valoración del Capital Cultural en escolares con situaciones de vulnerabilidad social
Authors: Villarroel Eduardo José Weffer
Published: January 2019

La educación, como un acto de vital importancia en la sociedad, constantemente esta inmersa en momentos históricos, sociales y contextuales que sin duda alguna buscan ajustarla a los requerimientos y necesidades que se viven y experimentan. Es así que en los actuales  momentos estamos sumergidos en nuevos caminos investigativos y de aportes teóricos, filosóficos y pedagógicos que buscan posicionar la tarea de educar en un elemento trascendental de humanización ante escenarios  de crisis sociales y otros aspectos degradantes y divisorios en la sociedad de hoy. Resulta evidente además que la formación de las nuevas generaciones amerita estar enmarcada dentro de  dinámicas sociales que permitan generar cambios positivos y consolidar así una sociedad cada día más justa, donde se resalte lo subjetivo y humano, la igualdad de condiciones, entre otros intereses consagrados como derechos humanos. En el presente ejercicio investigativo y hermenéutico de tipo documental, se mostraran inquietudes, reflexiones y posibles sugerencias que de una u otra manera buscan dar un aporte a la educación en los actuales momentos, específicamente en espacios sociales y educativos donde las condiciones de vida y convivencia no son las más adecuadas, pues en los mismos se enfrentan un sinfín de situaciones que desde la educación se han encontrado desasistidas. Me permito entonces a través de este texto el intento de posibilidades en las  formas y maneras de encontrarnos con nosotros como docentes y con nuestros estudiantes para así  asumir, apreciar, propiciar y atender  el acto de educar como una posibilidad de formación para la vida.

Palabras claves: Educación; Condición Humana; Pedagogía; Formación para la Vida.
Request Realisations in Cameroon Pidgin English
Authors: Kouega Jean-Paul
Published: January 2019

Pragmatic investigations into Cameroon Pidgin English are rare and works on requests are non-existent. This study sets out to outline the rules that underlie requests in this language and the lexical and structural features that realise them. The informants were 30 fluent Pidgin English speakers who were found communicating in Pidgin in public settings like bars and who were willing to join in a writing exercise. The instrument used was a collection of ten request fragments that had occurred in natural Pidgin conversation. These informants were asked to compose a possible conversation between two familiar equals in which one of these fragments like “Put the potatoes in the bucket” could fit squarely. The frame adopted for data analysis was Blum-Kulka and Olshtain’s 1984 research on requests and apologies, whose aim was to specify the particular pragmatic rules of use for a number of languages including English and German. The analysis revealed that the constituents of a request utterance were the same as previous researchers had identified. Besides the most frequent request strategy type used was “reference to preparatory conditions” (31.57% of 38 utterances) followed by “hedged performatives” (26.31%).
MACROSTRUCTURAL ANALYSIS OF FRICTION STIR WELDING (FSW) JOINTS
Authors: Kossakowski Paweł Grzegorz , Wciślik Wiktor , Bakalarz Michał
Published: January 2019

Friction Stir Welding (FSW) technology is increasingly used in aerospace, automotive, construction and other industries. It allows for safe, secure and long-lasting joining of materials that are difficult to weld or non-weldable with traditional methods. In engineering practice, these are primarily aluminium alloys.
INTEGRATION OF INTERNALLY DISPLACED PERSONS IN THE SOCIETY
Authors: Krakhmalova Nina A.
Published: January 2019

The paper seeks to provide insights to the nature and problematic issues as well as to specify the institutes for adaptation and integration of internally displaced persons in modern Ukraine. Yet, a vast range of problems faced by IDPS in the process of their adaptation remains unresolved so far. Among the major challenges of IDP social integration are as follows: housing and employment problems, financial hardship, dissolution of family ties, the problem of adaptation, etc. The situation and problems of internally displaced persons have been analyzed along with providing a socio-demographic portrait of IDP in Ukraine, the key challenges for IDPS have been revealed. According to the survey, forced migrants maintain close relationships with charity organizations and government social services (respectively 69% and 44% of respondents, respectively). The problem of employment is the survival issue for IDPS in modern realia, since the government support fails to cover even the accommodation costs. Housing rent and utilities expenditures account for almost the entire income of IDPS. Apart from financial problems, a great number of IDPS worry about the ongoing war in Ukraine and strive for peace (84% of respondents) as well as the failure to be with their families (42% of respondents), which are important for the process of adaptation. The research findings offer the following recommendations to be undertaken: the government support must primarily be targeted to resolve the major problems that IDPS cannot overcome on their own, i. e. finding a place to live and employment. It is critical to create favourable environment and incentives for those employers who employ migrants. This will raise the level of IDPs competitiveness in the labour market, thus making their adaptation much easier. Since people have undergone through extremely traumatic experiences due to military actions and the process of resettlement, forced migrants need psychological assistance. Local communities should engage IDPS into social events to foster their integration. In conclusion, it is argued that internally displaced persons are a potential that will allow Ukraine to flourish, live in peace and consent in a single territory, for the sake of a bright future of the nation. The strategies and mechanisms for internally displaced persons adaptation and integration into the new social and cultural environment have been explored; the role of the government, volunteers and international organizations in promoting the adaptation and integration of internally displaced persons has been specified.
МЕТОДИЧНІ ЗАСАДИ ОЦІНЮВАННЯ КОНКУРЕНТОСПРОМОЖНОСТІ АВТОМОБІЛЕБУДІВНИХ ПІДПРИЄМСТВ У КОНТЕКСТІ ФОРМУВАННЯ ДЕРЖАВНОЇ СТРАТЕГІЇ РОЗВИТКУ АВТОМОБІЛЕБУДУВАННЯ
Authors: Шевченко Інна Юріївна
Published: January 2019

An important part of domestic machine-building sector is the automotive industry represented mainly by car, truck and bus manufacturing. It is hardly a secret nowadays that the Ukrainian automotive industry is facing tough times, thus failing to withstand strong competition from foreign car manufacturers. In this context, as never before, the issue to enhance the government support of domestic automakers is of a critical importance. It is expected that the implementation of government strategy for automotive industry development will have different effects at discrete automotive companies subject to their different competitiveness level. Hence, there is a need to conduct a research on developing a methodological toolkit for the automotive company competitiveness evaluation. The research objective is to construct a methodological framework to assess automotive manufacturers’ competitiveness in the context of building the government strategy to enhance the automotive industry development. The study has employed the following methods: a monographic method and the method of theoretical generalization to identify the most widely used methodological approaches to company competitiveness assessment; a method of analysis and synthesis for elaborating a methodology to assess the automotive industry competitiveness in the context of building the government strategy for automotive industry development. Based on the combination of integral and matrix approaches, an evaluation framework to estimate the automotive company competitiveness has been designed. The method suggested, in contrast to other techniques described in academic literature, allows for the identification of car manufacturers competitiveness by integral indices values along with revealing the stages of their life cycle. The synthesis of the results of automakers competitiveness estimation and identification of the stages in their life cycle laid the foundation for the construction of the automotive industry development matrix which in turn is the basis for tailoring of government strategy to enhance the automotive industry development. Working out a set of methodological tools to evaluate the competitiveness of the automotive industry contributes to further development of methodical framework of government regulation in terms of facilitating the automotive industry competitiveness towards its focus differentiation, thus increasing the managerial effectiveness.
ВПЛИВ ІНФОРМАЦІЙНИХ ТЕХНОЛОГІЙ НА ПРОЦЕС МІЖКУЛЬТУРНОЇ КОМУНІКАЦІЇ В АСПЕКТІ РОЗВИТКУ МІЖНАРОДНОГО МАРКЕТИНГУ ТА ГЛОБАЛІЗАЦІЙНИХ ПРОЦЕСІВ
Authors: Птащенко Олена Валеріївна , Родіонов Сергій Олександрович , Кущ Яна Миколаївна
Published: January 2019

Mass media globalization as part of the global informatization process encourage separate research endeavors, further explanation and analysis for a number of reasons, in particular, due to its scale, consequences and perspectives of the complex and dominant economic impact on all aspects of the economy as well as on humanitarian domain of social life. In modern realia, a generally accepted understanding of information technology has emerged, i. e. being a set of methods and software tools that are integrated into a technological chain to ensure the information accumulation, processing, storage, distribution and display. Apparently, global cultural affinity is gained through mass media to a much greater extent than by technological aspects of globalization – it is simply wider than the scope of such technology components as networks, mobile communications, television, etc. however, despite the above mentioned, the mass media development pace as a global tool is significantly more slowly than particular technological solutions and instruments of globalization. When considering globalization through the prism of mass media as a driver of international marketing development, it becomes clear that it is a powerful but yet, most frequently, a destructive instrument that has the capacity and the ability to bypass various formal barriers, such as sovereignty, independence, national specifics, etc. Moreover, we should not ignore the possibility of avoiding an “information war” phenomenon, either. The paper provides insights into the role of information technologies in establishing a dialogue and consent in modern society, it also seeks to evaluate their manifestation and effects on the process of cross-cultural communication in the context of international marketing development and globalization.
البداء والعلم الإلهي المطلق
Authors: جليب دارم بركاوي , حمد علي جاسم
Published: January 2019

البداء عقيدة إسلامية أقرت بها جميع الفرق, إذ لا خلاف في الجواهر إنما الخلاف في المظاهر تتعلق بنوعية الأعمال الصالحة والطالحة وأثرها في تغيير أقدار العباد , فهي نسخ في المجال التكويني كالإفقار بعد الإغناء, والإماتة بعد الإحياء, والإمراض بعد الإعفاء, تكشف عن القدرة المطلقة لله تعالى وسلطته على إبدال تقدير العباد بحكمة مع مدخلية للسلوك الإنساني بذلك فهو من يهيء لنفسه منافذ تغيير قدره مع علمه سبحانه وتعالى بكلا التقديرين في أم الكتاب, وينجم عن هذا المعتقد آثار تربوية ونفسية تساعد على إصلاح الفرد والمجتمع, فليس لهذا المبدأ صلة بتجدد علم الله تعالى أو ظهور ما كان مخفياً عنه والعياذ بالله كما يصوره ويلصقه بعضهم على الشيعة الإمامية كذباً وإفتراءاً, إذ أخذ البداء طابع الإفتراء واستعمل أداة للتقريع والتشنيع دون دراية و رويّة .
الطباعة والصحافة والمكتبات في لواء العمارة حتى عام 1958
Authors: الركابي عكاب يوسف , غيلان الربيعي حسين عبد علي
Published: January 2019

أن دراسة الروافد الثقافية الخاصة في لواء العمارة المتمثلة في الطباعة والصحافة والمكتبات حتى عام 1958, يتطلب الوقوف على أوضاع العراق في عهد الدولة العثمانية التي كانت متأخرة عن دول العالم الأخرى بيد إنها عرفت الطباعة متأخرة وبذلك كانت معرفة العراقيين بها متأخرة بسبب تخلف الدولة العثمانية برمتها, وبعد أن عرفتها الدولة العثمانية أخذت تتسرب المطابع إلى مدن العراق بصورة تدريجية حيث ظهرت أول مطبعه في مدينة كربلاء عام 1956 ثم لحقتها مطبعة أخرى في بغداد عام 1861 ثم جاءت مطبعة الولاية عام 1869 في عهد الوالي مدحت باشا وبذلك عرف العراق هذا المجال ونشطت المطابع في العراق في مدة ما بين الحربين العالميتين .
I-THS-1908 A Big Data Electronic Health Record for Patient Care Management and Analytics
Authors: Hidayat Ahmad , Hasani Arief
Published: January 2019

The I-THS-1908, a big data electronic health record platform, is capable of establishing its capability as an electronic health record to tackle the large volume of data with high velocity and complex variety of patient data by providing the value to the patient care management and analytics. The further development of I-THS-1908 opens the opportunity to use the electronic health record for patient care management and analytics for all type of health conditions.
MAKALAH PENULISAN DAFTAR PUSTAKA DENGAN MENGGUNAKAN METODE HARVARD,VANCOUVER DAN APA
Authors: mawu moses jakson umbu
Published: January 2019

Daftar pustaka berisi informasi tentang sumber pustaka yang telah dirujuk dalam tubuh tulisan. Format perujukan pustaka mengikuti cara Harvard,cara Vancouver ataupun cara APA. Untuk setiap pustaka yang dirujuk dalam naskah harus muncul dalam daftar pustaka, begitu juga sebaliknya setiap pustaka yang muncul dalam daftar pustaka harus pernah dirujuk dalam tubuh tulisan. Sistem Harvard menggunakan nama penulis dan tahun publikasi dengan urutan pemunculan berdasarkan nama penulis secara alfabetis. Publikasi dari penulis yang sama dan dalam tahun yang sama ditulis dengan cara menambahkan huruf a, b, atau c dan seterusnya tepat di belakang tahun publikasi (baik penulisan dalam daftar pustaka maupun sitasi dalam naskah tulisan). Alamat Internet ditulis menggunakan huruf italic. Terdapat banyak varian dari sistem Harvard yang digunakan dalam berbagai jurnal di dunia. Sistem Vancouver menggunakan cara penomoran (pemberikan angka) yang berurutan untuk menunjukkan rujukan pustaka (sitasi). Dalam daftar pustaka, pemunculan sumber rujukan dilakukan secara berurut menggunakan nomor sesuai kemunculannya sebagai sitasi dalam naskah tulisan, sehingga memudahkan pembaca untuk menemukannya dibandingkan dengan cara pengurutan secara alfabetis menggunakan nama penulis seperti dalam sistem Harvard. Sistem ini beserta variasinya banyak digunakan di bidang kedokteran dan kesehatan. “Smith (1983) menemukan bahwa tumbuhan pengikat N dapat diinfeksi oleh beberapa spesies Rhizobium yang berbeda”. “Integrasi vertikal sistem rantai pasokan dapat menghemat total biaya distribusi antara 15% sampai 25 % (Smith,1949, Bond et al., 1955, Jones dan Green, 1963).” “Walaupun keberadaan Rhizobium normalnya mampu meningkatkan pertumbuhan kacangkacangan (Nguyen, 1987), namun telah didapat pula hasil yang berbeda bahkan berlawanan (Washington, 1999).”
EKSPLORASI POTENSI MEDIA ONLINE VIVA.CO.ID DAN METROTVNEWS.COM SEBAGAI PEMBENTUK OPINI PUBLIK
Authors: Satria Dadi , Adek Muhammad
Published: January 2019

Artikel ini bertujuan untuk mengungkapkan potensi media online viva.co.id danmetrotvnews.com sebagai pembentuk opini publik melalui struktur mikro yang dilihat daripenggunaan kata ganti dan pilihan kata. Kajian ini merupakan penelitian kualitatif denganmenggunakan metode deskriptif. Instrumen dalam studi ini adalah peneliti dengan menggunakanalat bantu lembar pengumpulan data. Data penelitian ini adalah kalimat dan paragraf yangmenunjukkan struktur mikro berita viva.co.id dan metrotvnews.com yang memuat topik yangsama. Sumber data penelitian adalah berita media online viva.co.id dan metrotvnews.comperiode Januari 2018. Pengumpulan data dilakukan dengan membaca, memahami, danmelakukan pencatatan berita media online viva.co.id dan metrotvnews.com. Pengabsahan datadilakukan dengan teknik triangulasi. Analisis data dilakukan dengan membaca data,mengumpulkan berita yang memuat topik yang sama, mencatat kutipan-kutipan sesuai denganstruktur teks, mengelompokkan kutipan-kutipan tersebut, menjelaskan pendayagunaan, danmenyimpulkan hasil penelitian. Berdasarkan temuan penelitian, kata ganti yang digunakandalam berita viva.co.id sengaja menciptakan kelompok imajinatif untuk membentuk solidaritas,aliansi, dan perhatian publik serta mengurangi kritik dan oposisi. Berbeda denganmetrotvnews.com yang berusaha menghilangkan jarak dan batas antara komunikator danpembaca serta membentuk pendapat pribadi menjadi pikiran bersama. Berdasarkan strukturstilistik, viva.co.id membangun berita melalui pilihan kata dan kalimat yang baik agar pembacamudah memahami informasi yang disampaikan dan menciptakan kesan positif dari setiappemberitaan. Metrotvnews.com lebih cenderung mengungkapkan fakta secara terbuka kepadapembaca tanpa menyembunyikan realita melalui pilihan kata.
KEMAMPUAN PEGAWAI DAN IMPLIKASINYA TERHADAP KINERJA PEGAWAI PADA DINAS LINGKUNGAN HIDUP KOTA SUKABUMI
Authors: Riyanto Andi
Published: January 2019

Tujuan dari penelitian ini adalah untuk mengetahui kemampuan pegawai pada Dinas Lingkungan Hidup Kota Sukabumi, mengetahui kinerja pegawai pada Dinas Lingkungan Hidup Kota Sukabumi, dan untuk mengetahui efek kemampuan pegawai terhadap kinerja pegawai pada Dinas Lingkungan Hidup Kota Sukabumi. Variabel dalam penelitian ini terdiri dari variabel bebas berupa variabel kemampuan pegawai dan variabel terikat berupa kinerja pegawai. Metode penelitian menggunakan metode deskriptif dan asosiatif melalui teknik survei. Populasi dan sampel sebanyak 60 pegawai pada Dinas Lingkungan Hidup Kota Sukabumi. Penelitian ini menggunakan teknik non-probability sampling, maka tidak dilakukan uji hipotesis statistik. Hasil penelitian yang diperoleh menunjukkan besarnya efek dari kemampuan pegawai terhadap variabel kinerja pegawai pada Dinas Lingkungan Hidup Kota Sukabumi.
Concentration and Human Health Implications of Trace Metals in Fish of Economic Importance in Lagos Lagoon, Nigeria
Authors: Oguguah Ngozi
Published: January 2019

Background. The most significant sources of food-borne diseases are microbiological and chemical hazards. The health risk due to consumption of food from aquatic ecosystems contaminated with hazardous chemicals including metals has increased globally, especially in developing countries like Nigeria.Objectives. The concentration and human health implications of trace metals in fish of economic importance in Lagos lagoon were investigated by determining the degree of contamination with heavy metals of selected fish from Lagos lagoon and assessing the possible health risks associated with fish consumption.Methods. Fish of economic importance including Caranx hippos, Chrysichthys nigrodigitatus, Elops lacerta, Galeoides decadactylus, Ilisha africana, Liza falcipinnis, Lutjanus goreensis, Mugil cephalus, Pseudotolithus senegalensis, Sarotherodon spp, Sphyraena spp, and Tilapia spp were bought from fishermen fishing in Lagos lagoon. The fish tissue samples were digested and analyzed in five replicates for heavy metals (lead, cadmium, iron, manganese and zinc) using a Varian AA600 atomic absorption spectrometer.Results. There were considerable variations in the concentrations of heavy metals among different species. The twelve fish species collected from Lagos lagoon were found to contain various concentrations of heavy metals and the levels of accumulation of these heavy metals varied across different species. Lead, cadmium, and manganese were present in all the studied fish species at higher concentrations than the maximum allowable concentrations in fish recommended by the Food and Agricultural Organization (FAO) and World Health Organization (WHO). The target hazard quotient (THQ) estimated for individual heavy metals through consumption of different fish species was less than 1 for all individual heavy metal in all the fish species.Conclusions. Controls on the dumping of wastes in the lagoon are needed, along with regular monitoring. Currently, no potential non-carcinogenic health risks from ingestion of a single heavy metal through consumption of these fish species was found.
Galectin-3 as the marker of hypertrophy and myocardial dysfunction in males with essential hypertension, carriers of polymorphic genes of angiotensin ii type 1 receptor
Authors: Ruzhanskaya V.O. , Sivak V.G , Sakovych O.O. , Zhebel V.M.
Published: January 2019

One of the main etiological causes of development of heart failure is essential hypertension. The diagnosis of heart failure is usually made on the basis of comprehensive analysis of medical history, sonographic and biochemical examination. Normal ejection fraction does not exclude dyspnea of cardiac origin. Objective: to determine the role of galectin-3 as a marker of structural and functional changes of the myocardium in males with essential hypertension and CHF, carriers of polymorphic AT1R genes, residents of Podillya region of Ukraine. In this contingent, the surveyed were studied сoncentrations of galectin-3 and brain natriuretic peptide (BNP), parameters of central and systemic hemodynamics in carriers of polymorphic variants of angiotensin II type 1 receptor gene (АТ1R) - individuals with no cardiovascular pathology (n=79), male patients with II-III degree essential hypertension (EH) and hypertrophy of the myocardium (n=62), and essential hypertension (n=50) complicated by chronic heart failure (CHF), residents of Podillya region of Ukraine, were studied. Genotyping of АТ1R gene was performed using polymerase chain reaction. Galectin-3 and brain natriuretic peptide levels were determined by enzyme immunoassay. Structural and functional parameters of myocardium were assessed by ultrasound using the apparatus “RADMIR ULTIMARA”. Statistical analysis of the results obtained was done on personal computer using standard statistical package Statistica 10.0. The data are represented as mean values (M) and standard deviations (±m). Carriers of C allele of angiotensin II type 1 receptor gene were found to be dominating among the males with essential hypertension and resultant myocardial hypertrophy. Concentrations of galectin-3 and brain natriuretic peptide were significantly higher in men with essential hypertension and essential hypertension associated with chronic heart failure, as compared to those with no cardiovascular diseases, as well as the carriers of C allele of angiotensin II type 1 receptor gene. It was found that concentrations of study biomarkers were higher in individuals with severe and eccentric left ventricular hypertrophy, as well as in those with decreased ejection fraction of the left ventricle. Therefore, those biomarkers can be used in complex diagnosis of left ventricular hypertrophy in essential hypertension and the development of chronic heart failure in such patients.
Retrospective analysis of risk factors for occurrence of pancreatic fistula in patients following pancreaticoduodenectomy
Authors: Valikhnovska K.G.
Published: January 2019

Pancreaticoduodenectomy still is a “gold standard” in treatment of hepatopancreaticobiliary tumors. The causes of pancreatic fistula were analyzed in 414 patients aged from 22 to 81 following pancreaticoduodenectomy due to periampullary tumors. The said patients were operated on during the period from 2008 to 2017. The aim of this study is to improve outcomes of pancreatic resection based on a retrospective analysis of the causes of postoperative pancreatic fistulae and the development of a range of measures to prevent the above complication. Influence of risk factors of pancreatic fistula formation was evaluated by Pirson’s method (χ2). The factors contributing to the occurrence of pancreatic fistulas included type of resection (Whipple pancreaticoduodenectomy, pylorus preserving pancreaticoduodenectomy; χ2=8.616,1, p=0.0033, p<0.01), kind of pathology (cancer of the pancreatic head; χ2=7.658,1, p=0.0057, p<0.01), type of pancreaticojejunostomy (invaginative pancreatic duct-jejunostomy; χ2=17.83,1, p=0.0001, p<0.001) and technique for drainage of the major pancreatic duct (pancreaticojejunostomy on external drainage; χ2=16.40,1, p=0.0001, p<0.001). The detailed study of risk factors for the occurrence of pancreatic fistula is essential for improving the prognosis, prophylaxis and treatment of this pathology. The quality of the surgical intervention and the course of the postoperative period in patients with periampullary tumors depend on the choice of resection type, techniques for surgical interventions on the pancreas.
Choice of tactics of surgical treatment of acute cholecystitis and its complications
Authors: Zaporozhchenko B.S. , Kravets K.V. , Borodaev I.E. , Bondarets D.A. , Bondarets D.A. , Muraviov P.T.
Published: January 2019

Acute cholecystitis ranks second in the incidence of urgent surgical diseases in hospitals in Ukraine. Despite a marked improvement in the treatment results, the lethality after emergency operations (9,4-37%) for acute cholecystitis complicated by peritonitis remains several times higher than with routine surgical interventions. Objectives — development of rational surgical tactics and evaluation of the effectiveness of treatment of acute cholecystitis and its complications in patients of different age groups, with different pathomorphological forms of acute cholecystitis. The result of treatment of 203 patients was presented: 75 (37,5%) were operated on an emergency basis, 73 (36,5%) urgently, and 52 (26%) in a deferred period. 173 (86.5%) patients were operated using laparoscopic technologies. Intraoperative cholangiography was performed in 16 (9,3%) patients during laparoscopic interventions. In 17 (8,5%) patients, “open” operations were performed. All patients underwent drainage of the abdominal cavity with one or more drains in view of the presence of peritonitis. The average duration of the preoperative period was 1.5 days, the total duration of treatment with LC was 4.5 days, and the total duration of treatment with OC was 10.8 days. So, in the early stages of the development of acute cholecystitis, laparoscopic cholecystectomy is effective. The use of lifting systems for laparoscopic cholecystectomy is advisable in elderly and senile patients, with concomitant diseases of the heart and lungs.
Some indicators of hemostasis in patients with ischemic heart disease and coronary angioplasty
Authors: Storozhuk N.V. , Luhovskoy E.V. , Storozhuk B.H , Platonova T.M. , Kolesnikov I.M.
Published: January 2019

The effect of hemostasis parameters on the development of stent restenosis / thrombosis requires further investigation. The purpose of the paper is to find out the informativeness of activators and inhibitors of the circulating blood system as markers for the development of thrombotic complications in patients with ischemic heart disease and coronary angioplasty. 92 patients (78 men and 14 women) with ischemic heart disease and coronary angioplasty were examined, of which 33 cases suffered from stent restenosis/thrombosis. The patients were simultaneously evaluated for hemostasis parameters (soluble fibrin, D-dimer, protein C, and fibrinogen). It is determined that in patients with ischemic heart disease who have undergone angioplasty in 67.4% of cases there is a significant increase in the level of soluble fibrin with subsequent significant increase in patients with a history of restenosis. It is established that the level of D-dimer in these patients is significantly lower, while in the women it is significantly lower than that of the studied men. The reaction of anticoagulant protein C in 42.4% of patients tends to decrease, taking into consideration that in 80.4% cases there is significant fibrinogenemia. Therefore, the study reveals a significant imbalance in the system of pro- and anticoagulation in this category of patients in favor of the coagulation link, and the hemostatic parameters studied in the complex can be used as informative integral markers of thrombinemia.
The complex treatment of patients with perforated gastroduodenal ulcers
Authors: Pokydko M.I. , Formanchuk T.V. , Goncharenko O.V. , Formanchuk A.M. , Katsal V.A.
Published: January 2019

To improve the immediate results of surgical treatment of patients with perforated gastroduodenal ulcers using minimally invasive correction and an integrated treatment. The results of 253 patients with perforated gastroduodenal ulcers who were treated from 2013 to 2018 were analyzed. Chronic ulcers were found in 82 (32%) cases among all gastric ulcers, acute ones constituted 42 (16%) cases. Chronic duodenal ulcers reached 94 (37%), acute ones constituted 35 (14%). The diagnostic laparoscopy was performed in 13 (5%) patients, in 8 (3%) patients the perforated hole was sutured laparoscopically and in 5 (2%) patients the conversion was performed. Abdominocentesis with preoperative abdominal cavity drainage was carried out in 45(18%) patients. Through this drainage after exudate evacuation 200 ml of dekasan solution was injected. In 119 cultures of abdominal exudates with determinate pathogenic microflora Enterococcus faecalis dominated - 31 patients (26%). Among the postoperative complications the failure of intestinal sutures was observed in 4 (1.5%) patients. Postoperative mortality was 11.5%. Progression of multiple organ failure became the cause of mortality in 17 (59%) patients. Thus, the time from the moment of perforation till the moment of surgery must not be the sole criterion in the choice of method of operative intervention, and it is insufficient as an absolute indicator for the possibility of the radical surgical procedures (gastric resection). Undoubtedly laparoscopic suturing of the perforated gastroduodenal ulcer has advantages over laparotomy.
Whether poor responses have worse perinatal prognosis (retrospective analysis of assisted reproductive technologies cycle)
Authors: Strelko G.V.
Published: January 2019

The prevalence of poor ovarian response is 5.6–35.1% in women undergoing controlled ovarian stimulation in ART cycles. The frequency of delivery of poor responders after ART is on average from 9.9% to 23.8%. In clinical practice, the vast majority of poor responders are older women, which may have an effect on perinatal outcomes, respectively. Although numerous studies have reported that the fertility rate after ART in women of this age group is quite low, data on perinatal outcomes in this group of women is limited. Therefore, the aim of our study was to retrospectively analyze and compare perinatal outcomes in women with poor ovarian response to stimulation compared to control group (normal response to stimulation) in assisted reproductive technology programs. 278 women with infertility with a reduced response to stimulation (poor responders), who were the main group, were screened. Indications for the inclusion of women in the main group were the presence of at least two of the following criteria for a poor ovarian response according to the 2011 Bologna criteria and 93 infertile patients with a normal ovarian response to stimulation of the control group. Subsequently, retrospective study of perinatal effects such as preterm labor, low birth weight, gestational diabetes, preeclampsia in 50 women with infertility with reduced response to stimulation and 37 controls with normal response to stimulation in which pregnancy was diagnosed was performed. Variational-statistical processing of the results of the study was performed using the program “Statistica 6.0”. The study demonstrated a significantly lower pregnancy rate in poor responders compared with women from the control group — 50 (17.9%) vs. 37 (39.8%), respectively. Perinatal outcome were similar only to the statistically significant difference in the percentage of spontaneous abortions before 12 weeks of gestation — 9 (18%) vs. 4 (10.8%), respectively, in groups with no significant difference in the preterm labor frequency — 10 (20.8%) and 6 (18.1%) of the low weight of the child at birth — 9 (18.7%) versus 5 (15.1%), respectively, in poor responders patients and in women with normal ovarian response. The frequency of complications such as gestational diabetes and high blood pressure were not significantly different in both clinical groups — 3 (6.25%) versus 2 (6.1%) and 5 (10.4%) versus 3 (9.1%) respectively. Thus, he poor responders in ART programs have a significantly lower pregnancy rate and a higher incidence of pregnancy loss up to 12 weeks compared with women who had a normal response to ovarian stimulation without a significant difference in the rates of various complications of pregnancy and perinatal outcomes. Wide randomized multicentric trials are needed to find out the causal relationships with regard to the effect on pregnancy, miscarriage, perinatal effects of controlled ovarian stimulation regimens, embryotransfers in fresh or cryo cycles etc.
Effectiveness of the endoscopic treatment for malignant extrahepatic biliary obstruction
Authors: Mamontov I.N. , Tamm T.I. , Kramarenko K. A. , Bardiuk A. I.
Published: January 2019

The causes of malignant extrahepatic biliary obstruction (MEBO) are pancreatic head carcinoma, ampulloma, cholangiocarcinoma, gall bladder cancer, less often — metastatic lymph nodes. Endoscopic biliary drainage (EBD) of extrahepatic ducts (ED) including stent placement plays a key role for cholestasis resolving. Aim — to evaluate the effectiveness of EBD in case of MEBO, depending on its level. Data of 36 patients with MEBO treated with EBD were retrospectively analyzed. Statistic methods: mean value and standart diviation were used. Ampulloma was the cause of MEBO in 7 cases, EBD was effective in all of them. Of 18 patients with MEBO at the level of distal 1/3 of ED, EBD was effective in 13. In the case of an MEBO of the middle 1/3of ED, EBD was successful in 3 of 6 patients, in the proximal 1/3 — in 3 out of 5. Thus, endoscopic biliary drainage was successful in 72% cases of malignant biliary obstruction. In case of obstruction at the papilla level, the success of endoscopic drainage has been achieved in all cases. Failure of EBD was due to inability of performing ERCP — mainly in cases of distal obstruction and the inability to get through obstruction — in the middle and proximal sections of the extrahepatic biliary tract.
The place and role of videothoracoscopic surgical interventions in war wounds and injuries of the chest organs
Authors: Khomenko I.P. , Gerzhyk K.P. , Kucher B.M.
Published: January 2019

Thoracic injuries are considered to be one of the most severe injuries of human systems and organs, which are characterized by a large number of complications and high mortality. According to the ATO data in eastern Ukraine, the frequency of chest injuries in the general structure of combat surgical injuries is 11.7%, the overwhelming majority of which were non-penetrating injuries (83.6%). The overall mortality rate for penetrating wounds of the breast is 5–10%. Surgical tactics for injuries and injuries of the chest is diverse and depends on the type of traumatic injury, the time of first medical and specialized care, the severity of the condition of the victims, the presence of complications, the technical capabilities of the hospital. Objective: optimization of surgical tactics for wounds and injuries of the chest through the use of video-assisted thoracoscopic techniques. A retrospective analysis of the surgical treatment of 103 thoracic wounded and injured, which were located in the Military Medical Clinical Center of the Southern Region in Odessa and the area of responsibility (level II–IV medical care) from June 2014 to July 2017, was carried out. At the stages of medical evacuation of all 103 thoracic wounded and injured in most cases (41 people (39.8%)), drainage of the pleural cavity was sufficient to eliminate hemo- and pneumothorax — 25 (24.3%) underwent various surgical interventions from thoracotomic approaches, 16 (15.5%) had various video-assisted thoracoscopic surgeries, 16 (15.5%) had only surgical treatments for gunshot wounds, and 5 (4.9%) wounded and injured had only conservative therapy. Conclusions: Promising, in our opinion, can be the widespread introduction of video-assisted thoracoscopic interventions into the practice of surgeons who are involved in the ATO, followed by a multicenter assessment of the results.
Features of adequate intubating security in patients with odontogenic and tonsilogenic neck phlegmons
Authors: Shaprinskiy V.О. , Kryvetskyi V.F. , Suleimanova V.G. , Mitiuk B.O. , Dombrovskyi V.Iu.
Published: January 2019

Recently, a tracheostomy was considered the method of choice for provide ventilating of patients with deep neck phlegmons, but current trends recognize that tracheal intubation with bronchoscope is the most rational way of adequate breathing security in such patients. Objective - to investigate the peculiarities of features of adequate intu bating security in patients with odontogenic and tonsilogenic neck phlegmons. 70 patients with deep neck phlegmons of odontogenic 4(7 (67%)) and tonsilogenic origin - (23 (33%)) have been investigated. 47 (67%) suffered from descending mediastinitis. Tracheal intubation was performed using orotracheal laryngoscope, bronchoscope or through tracheostomy. 33 (47.1%) patients underwent orotra cheal intubation with a bronchoscope, 34 (48.6%) with a laryngoscope, and only in three cases (4.3%) tracheostomy was used. Bronchoscopic intubation was performed in 57.4% of patients with odontogenic phlegmons, and only in 26.1% cases of oropharyngeal spaces suppuration. The percentage of tracheostomies was the same in two groups of patients and showed 4.3%. Mortality rate was 12.9%. Thus, 57.4% of patients with odontogenic neck phlegmons need for bronchoscopic tracheal intubation, a tracheostomy is used extremely rarely (4.3%). Intubation with laryngoscope is possible in 70% of patients with tonsilogenic suppuration. Comparison of tracheal intubation in patients with deep neck phlegmons with and without descending mediastinitis is prospects for further research.
Dynamics of quality of life in patients with morbid obesity after biliopancreatic diversion and sleeve gastrectomy
Authors: Perekhrestenko O.V.
Published: January 2019

The rapid progress of obesity surgery dictates the necessity to study the quality of life of patients after bariatric procedures. The aim of the study is to assess the dynamics of quality of life of patients with morbid obesity after biliopancreatic diversion in the modification of Hess-Marceau and the sleeve gastrectomy in order to improve the results of surgical treatment of the specified category of patients. The results of surgical treatment of 205 patients with morbid obesity who performed sleeve gastrectomy (main group — 105 patients) or biliopancreatic diversion by Hess-Marceau (comparison group — 100 patients) were analyzed. The study of the dynamics of quality of life of patients was performed in according the Moorehead-Ardelt II method. Statistical data processing was performed using the methods of variational and descriptive statistic using Statistica 6.0 statistical analysis package. Installed that biliopancreatic diversion by Hess-Marceau and sleeve gastrectomy allowed to significantly improve the quality of life of patients with an increase of the quality of life index with -1.5±0.7 in the comparison group and -1.6±0,6 in the main group up to 1.8±0.3 and 2.0±0.4 respectively (p<0.05 compared to pre-operative data) 60 months after surgery. A more pronounced positive dynamics of quality of life in patients of the main group in the time interval of 12–24 months after the operation was achieved due to the absence of severe late metabolic complications and undesirable side effects of biliopancreatic diversion and laparoscopic access for sleeve gastrectomy in 54.3% of patients. Thus, the quality of life of patients with morbid obesity before performing bariatric surgery is critically low and significantly improved after biliopancreatic diversion by Hess-Marceau as well as sleeve gastrectomy. The impact of bariatric surgery on the duration and quality of life of patients requires further multicenter randomized trials.
Surgical treatment of uterine fibroids: current state of the problem and own experience
Authors: Martsynkovskyi I.P. , Stashchuk R.P. , Klymeniuk O.V. , Levchyk V.V. , Ivasiuk M.V. , Grebeniuk D.I.
Published: January 2019

Uterine myomas are the commonest gynecological tumors, with a prevalence of 70% to 80% in women who have reached the age of 50 years. In the contingent of women aged 25 to 44 years, the incidence is 8.9-30.9/1000. The prevalence of uterine myomas increases with age, peaking in women in 40 years. A hysterectomy study has found myomas in 77% of uterine specimens. In many women myomas may be asymptomatic and are diagnosed incidentally on clinical examination or imaging. However, myomas can cause significant morbidity including menstrual abnormalities (e.g. heavy, irregular, and prolonged uterine bleeding), iron deficiency anemia, bulk symptoms (e.g. pelvic pressure/pain, obstructive symptoms), and fertility issues. Symptomatic fibroids have a considerable impact on women's quality of life as well as their productivity. The article describes an overview of modern surgical methods for treating of uterine myomas. The advantages and disadvantages of each surgical method, indications and contraindications to their use are analyzed and described. Modern minimally invasive techniques for the treatment of uterine fibroids, such as uterine artery embolization and the use of focused energy delivery systems, are described. The clinical case of nodal symptomatic uterine myoma with necrosis of the fibromatous node in a patient treated in the Military Medical Clinical Center of the Central Region is given. The patient performed extirpation of the uterus with left appendages, right uterine tube.