bluuebunny/crossref_metadata_2025 huggingface dataset:
Regulation of environmental safety at the stages construction of main pipelines
Authors: Rudenko M. M. , Rudenko M. G.
Published: June 2023

Pipeline transport plays a special role in the unified transport system of the Russian Federation. Today, almost the entire volume of gas is delivered through the main pipelines. The technology of transportation of natural gas, oil, condensate and their byproducts, constructive solutions of the linear part and ground facilities influence the natural environment. Therefore, the issue of compliance with environmental protection rules in constructing pipeline transport facilities is relevant. It is of special significance due to the construction of new transport routes in the Asian region. The article analyzes legal documents on the stages of construction of linearly extended objects such as oil and gas pipelines. It was revealed that the compliance with the construction requirements reduces the damage to nature, but does not eliminate it. It was concluded that the production improvement is the most rational method of reducing the negative impact of construction on natural ecosystems. The analysis made it possible to provide recommendations for amending the environmental protection legislation.
Whether Economic Policy Uncertainty Instigates an Increase in The Cash Holdings of Singaporean-Listed Firms?
Authors: Thi Huong Giang Vuong  , Huu Manh Nguyen  , Wing-Keung Wong
Published: June 2023

Our paper investigates how economic policy uncertainty (EPU) affects Singaporean-listed firms’ corporate cash holdings after the global financial crisis. We apply various technical analyses for panel models of 4,253 yearly observations. Our results indicate that the Singaporean-listed firms’ cash holdings ratio (CHR) decreases when Singapore’s EPU increases in the period 2009–2018. Further, either global EPU or U.S. EPU indicators are correlated negatively with Singaporean-listed firms’ cash reserves. The corporate managers’ precautionary motive was not urged by the rise of EPU in the Singapore market. On the other hand, our empirical evidence suggests that Singapore’s corporate managers have an explicit speculative incentive in the context of the increased EPU in the post-financial crisis period. This research provides evidence that is at odds with the corporate managers’ classical view on precautionary cash savings in the context of the increased uncertainty of economic policy.
Impact of Cash Holdings on Firm Value: Role of Election Induced Political Uncertainty
Authors: Omar Farooq  , Zakir Pashayev
Published: June 2023

This paper uses presidential elections as the proxy for political uncertainties to investigate the impact of election induced political uncertainties on the relationship between cash holdings and firm value for a sample of non-financial firms from the U.S. The findings suggest that the impact of cash holdings on firm value goes down significantly during the years of presidential elections. This finding, however, is confined only to elections in which both presidential candidates are new and for firms headquartered in the states that have always voted for the Democrat candidates in the presidential elections. Furthermore, our findings suggest that the impact of political uncertainties on the relationship between cash holdings and firm value does not hold for gubernatorial elections. Our results are robust after including number of firm-specific and country-specific control variables and after taking into account potential endogeneity concerns.
Innovation and Firm Performance: The Moderating Role of Intellectual Capital among Chinese Companies
Authors: Chunya Ren  , Irene Wei Kiong Ting  , Qian Long Kweh  , Cheng Zhang
Published: June 2023

This study examines the impact of innovation on firm performance and how intellectual capital (IC) moderates the association between innovation and firm performance. We apply an innovation index that measures the frequency of innovative related words, which appear in firm financial reports to proxy for innovation. IC is estimated through the value-added IC (VAICTM) model. This study analyses Chinese firm-year observations of financial profitability (firm value) datasets, which total 19,152 (18,276) over the years from 2007 to 2019. Results indicate that the innovation index is positively related to financial profitability and firm market value. Moreover, the moderating outcomes suggest that IC boosts the positive relationship between innovation index and firm performance. Overall, this study highlights the importance of having innovation and IC together for gaining firm competitive advantages and progressing profitably. That is, firms should be innovative and must manage their IC well.
Corporate Social Responsibility and Revenue Misclassification: Evidence from India
Authors: Manish Bansal
Published: June 2023

The study examines the relationship between Corporate Social responsibility (CSR) and revenue misclassification in Indian institutional settings. Malikov et al. model has been used to operationalise revenue misclassification. Using a sample of Bombay Stock Exchange listed firms spanning over 14 years (March 2009 until March 2022), I find that CSR-oriented firms prefer revenue misclassification over expense misclassification for managing core earnings, consistent with the notion that CSR firms prefer earnings management (EM) tool having a greater relative advantage in terms of reporting favourable operating performance metrics. The subsequent tests suggest that big four auditors have a constraining effect on the revenue misclassification practices of firms. The findings alert auditors about the suspected firms (high-CSR firms) that are more likely to manage earnings through revenue misclassification and suggest authorities make more mandatory disclosure requirements for recording revenue items to curb the corporate misfeasance of revenue misclassification.
Corporate social responsibility in Latin American corporations: Role and importance
Authors: Rosana Espinoza-Rivera Fatima , Stefanny Huertas-Vilca Karla , Cecilia Obando-Peralta Ena , Cordova-Buiza Franklin
Published: June 2023

Corporate social responsibility (CSR) responds to the strategic management of corporate practices with ethical and sustainable commitment values. This study aims to describe the corporate social responsibility actions implemented in Latin America during the COVID-19 pandemic. The sample comprises such corporations as Arcor, Banco de Crédito e Inversiones, and Corporación Favorita, corresponding to Argentina, Chile, and Ecuador. The research methodology was based on a qualitative, cross-sectional, non-experimental design. The study conducted documentary analyses of the annual reports of these companies, ranked among the top CSR in the Merco Ranking. As a result, it was determined that the corporations carried out actions aimed at the economic dimension, with 36% in terms of equitable economic retribution to employees and 41% in terms of their recognition through incentives. Likewise, the social dimension showed that 57% of the company’s actions were aimed at collaborative support to foundations that ensured educational and health factors. On the other hand, the environmental dimension focused 69% of its activities on renewable energies as part of a policy of reducing pollutants. Finally, it can be concluded that CSR actions during the COVID-19 pandemic were used to ensure corporate stability through a range of activities with a socioeconomic and environmental focus without neglecting the strengthening of its corporate reputation.
Personnel motivation management in the strategic management system of an enterprise
Authors: Polhul Dmytro
Published: June 2023

In the paper, motivation management is considered through the prism of strategic personnel management, which is an important component of enterprise development. The overall strategy of an enterprise is mainly presented in the form of a long-term program of actions to implement the use and development of the organization’s available resources, but not always when describing a strategy, all its important elements are taken into account. Staff turnover, inconsistencies in the processes of hiring high-level specialists and low staff involvement are also the result of inadequate attention to the development of personnel motivation management policies, which accordingly hinders the development of an enterprise. The purpose of the paper is to substantiate the importance of motivation management in the strategic management system and develop scientific and methodological recommendations for improving the personnel motivation system as an effective tool to ensure the achievement of a company’s strategic goals. The result of the study was the definition of the main stages of the process of strategic personnel motivation management, namely: monitoring of motivation, determination of trends in changes in labor productivity from the introduction of new motivation systems; calculation of economic benefits from the implementation of employee motivation practices. The constructed logical-structural diagram of employee motivation management in the strategic management system, combined with periodic monitoring of the current employee motivation, will enhance the effectiveness of the development and implementation of both the motivation management strategy and the overall strategy of an enterprise.
ENGELLİ BİREYLERİN BÜROKRATİK İSTİHDAMININ SEMBOLİK TEMSİL BAĞLAMINDA DEĞERLENDİRİLMESİNE YÖNELİK NİTEL BİR ÇALIŞMA
Authors: DURMUŞ Merve
Published: June 2023

Toplumu oluşturan bütün demografik grupların bürokraside yer almasıyla daha cevap verebilir bir kamu hizmeti sağlanacağını ileri süren temsili bürokrasi teorisinin türlerinden olan sembolik temsil, temsilci bürokratların hiçbir çaba sarf etmese dahi kendi gruplarına faydası olacağını ileri sürmektedir. Bu savdan hareketle mevcut araştırma engelli bireylerin kamu kurumlarında istihdamının sembolik temsil bağlamında değerlendirilmesini amaçlamaktadır. Bu kapsamda çalışmada nitel araştırma yöntemi desenlerinden fenomenoloji kullanılarak engelli bireylerin bürokratik temsilinin sembolik etkileri ortaya çıkarılmaya çalışılmıştır. Araştırmanın çalışma grubu engelli istihdamında aktif görev almış bürokrat, siyasi, akademisyen ve sivil toplum kuruluşu üyelerini içeren 20 katılımcıdan oluşturmaktadır. Araştırmada yarı yapılandırılmış görüşme tekniği ile toplanan veriler içerik analiziyle analiz edilmiştir. Görüşmeler sonucunda elde edilen bulgular engelli bireylerin bürokratik temsilinin literatürle paralel olarak “toplumun engellilere karşı önyargısını azaltma, rol model olma, bürokrasinin meşruiyetini sağlama/ vatandaş gözünde adil ve güvenilir bir yönetim algısı oluşturma ve temsilci bürokratların motivasyonunun artmasını sağlama” yönleriyle sembolik temsili sağladığını göstermiştir.
ÇOCUK EVLERİNDE ÇALIŞAN BAKIM ELEMANLARININ PSİKOLOJİK İYİ OLUŞ DÜZEYLERİNİN İNCELENMESİ
Authors: İNCE KESER Esma , DEMİRCİOĞLU Haktan
Published: June 2023

Bu çalışmada çocuk evlerinde çalışan bakım elemanlarının psikolojik yönden iyi oluş düzeylerinin çeşitli değişkenler açısından incelenmesi amaçlanmıştır. Çalışmada amaçlı örnekleme yöntemi kullanılmış olup Türkiye’yi temsilen NUTS 2 (26 alt bölge) illerinde bulunan ve çocuk evlerinde çalışan 505 bakım elemanı (442 kadın, 63 erkek) çalışmanın örneklemini oluşturmuştur. Çalışma verileri “Gönüllü Katılım Formu”, “Bilgi Formu” ile “Psikolojik İyi Oluş Ölçeği” ile toplanmıştır. Verilerin analizinde Bağımsız Gruplar t testi ve Tek Yönlü Varyans Analizi (ANOVA) kullanılmıştır. Çalışma sonucunda, bakım elemanlarının psikolojik iyi oluş düzeylerinin, bakım elemanlarının yaşlarına, kendi çocuklarının duygusal ihtiyaçlarını karşılayıp karşılamadığına, çocuklarıyla sorun yaşama sıklığına, geçmişte psikolojik destek alıp almadığına, sportif faaliyetlerine katılım sıklığına, çocuk gelişimi ve eğitimi konusundaki bilgi düzeylerine göre anlamlı düzeyde farklılaştığı bulunmuştur. Bununla birlikte bakım elemanlarının psikolojik iyi oluş düzeylerinin, bakım elemanlarının çocuk evlerinde çalışma süresine, çocuk evindeki çocukların duygusal ihtiyaçlarını karşılama düzeylerine, çocuk evinde sorumlu oldukları çocuklarla sorun yaşama sıklığına göre anlamlı düzeyde farklılık gösterdiği ancak bakım elemanlarının psikolojik iyi oluş düzeylerinin, bakım elemanlarının cinsiyetine, eğitim düzeyine, kronik hastalığı olması durumuna göre anlamlı düzeyde farklılık göstermediği sonucuna ulaşılmıştır. Bulgular alanyazın doğrultusunda tartışılarak öneriler sunulmuştur.
BABALARIN ÇOCUKLARINA YÖNELİK ALGISI: İLK BABALIK DENEYİMLERİ
Authors: EROL Ahmet , CANBELDEK Merve , IŞIKOĞLU Nesrin
Published: June 2023

Bu araştırmanın amacı, ilk kez baba olan erkeklerin babalık rolü kavramına yönelik algılarının incelenmesidir. Çalışma nitel araştırma desenlerinden olgu bilim kapsamında yürütülmüştür. Çalışmaya ilk kez babalık deneyimi yaşayan Türkiye’nin güneybatısında bulunan bir üniversitede öğretim elemanı çalışan beş baba katılmıştır. Veriler üçlü görüşme metodu dikkate alınarak yarı yapılandırılmış görüşme protokolü aracılığıyla elde edilmiştir. Gerçekleştirilen birinci görüşmede katılımcıların yaşamlarına odaklanılmış, onları daha iyi tanımak ve deneyimlerini belirlemek amacıyla hazırlanan çeşitli sorular sorulmuştur. İkinci görüşmede katılımcıların deneyimlerinin detayları, ayrıntıları hakkında sorular hazırlanmış ve görüşme gerçekleştirilmiştir. Üçüncü görüşmede ise katılımcıların deneyimlerinden ne anlatmak istedikleri ve onların deneyimleri hakkında düşünmeleri istenmiş ve bu doğrultuda görüşme sonlandırılmıştır. Veriler içerik analizi yöntemiyle çözümlenmiştir. Bulgulara göre katılımcıların baba olma nedenleri hayatın anlamı, hayal kurma, yenilik ve üretim ve evliliğin devamı ile yakından ilgilidir. Katılımcılar baba olacaklarını anladıklarında ve baba olduklarında sorumluluk, mutluluk, heyecan, kaygı, aidiyet ve şaşkınlık hissetmişlerdir. Ayrıca, içinde bulundukları kültür babalık anlayışları üzerinde etkili olmuştur. Erkekler babalık deneyimlerini çocuğun bakımına katılma, ev işlerine yardımcı olma ve çocukla oyun oynama şeklinde açıklamışlardır. Bu sonuçlar ilk kez baba olan erkeklerin deneyimlerini ve çocuklarına yönelik algılarını anlamamıza katkı sağlamaktadır.
CHANGING FERTILITY PREFERENCES IN TÜRKİYE: ANALYSES BY PARITY
Authors: ABBASOĞLU ÖZGÖREN Ayşe , TÜRKYILMAZ Ahmet Sinan
Published: June 2023

The aim of this study is to examine changes in fertility ideals and intentions of women and fertility gap at both macro and micro level for the 1993-2018 period using data of Turkey Demographic and Health Surveys (TDHS), and to analyze fertility intentions of currently married women by parity, i.e. number of children ever born, using 2018 TDHS data employing descriptive and logistic regression methods. According to the findings, while ideal number of children increased in the 25-year period, intended number of children decreased. Although fertility gap is positive when using conventional TFR, it is negative when adjusted TFR is used, meaning actual fertility is greater than ideal or intended number of children. There has been an increase in the level of pronatalism in Türkiye recently, but it would be wrong to conclude that this is reflected in intentions and behaviors. Our multivariate findings covering all parities show that age and child-related variables are important determinants of women's fertility intention. Additionally, region, mother tongue and use of contraceptive methods are important. Socioeconomic variables, however, were not found to be significantly associated with birth intention. Some of these were found to be significant in intention for progression to first- and second-births.
Vibrator with two impacting pairs, one of them in the position of equilibrium
Authors: Ragulskis K. , Ragulskis L.
Published: June 2023

In the dynamic processes taking place in manipulators and robots, impact interactions play an important role. Among them two sided impacts are important. In this paper investigation of dynamic regimes of a system with two impacting surfaces, one of which is in the position of equilibrium is performed. Dynamics in steady state regime for typical parameters of the investigated system having one degree of freedom is investigated. Displacements as functions of time as well as velocities as functions of time for various positions of the impacting surface are presented. Non symmetric impacts enable to reduce the dimensions of the vibrator and to achieve increase of effectiveness of useful impacts of a manipulator. Investigations of the conservative system as well as of the system with forced harmonic excitation are performed.
Field test of blasting vibration and adjacent slope stability under the influence of blasting vibration in mining
Authors: Liu Can , Wang Feifei , Ren Qingyang , Chen Bin , Jin Honghua , Cui Songjun , Zhu Ziqiang
Published: June 2023

Blasting mining in open-pit has a significant impact on the adjacent slope, which often causes the rock mass cracking and spalling of the slope to form a landslide disaster. In order to explore the impact of blasting vibration on the adjacent slope, field tests were carried out with professional testing equipment, and several blasting vibration data were measured. Sadovsky formula was used for fitting analysis, and the influence coefficient of blasting vibration was obtained. The slope stability analysis was carried out by using the limit equilibrium SLIDE analysis software, and the slope safety factor under the influence of blasting vibration was obtained. The results show that: The maximum blasting vibration speed monitored in this blasting is 2.1987 cm/s, and the main vibration frequency is 14.6484 Hz. Therefore, according to the standards in the regulations, the impact of this blasting on the slope meets the corresponding requirements. In this slope stability analysis, the blasting vibration influence coefficient Kc= 0.032, when 40 m away from the final slope is used. Morgen Prince method and Spencer method generally have higher safety factors than Bishop method. The safety factor of the analysis section at the 45° slope angle is 1.217. The slope can maintain stability under the influence of blasting vibration.
Modern development of metamaterials for obtaining special electromagnetic, acoustic, mechanical and vibration-isolating properties
Authors: Valeev Anvar , Zotov Alexey , Siraeva Aliia
Published: June 2023

The article presents the history of the development of metamaterials, which begins with the development of metamaterials to obtain unique electromagnetic properties. The first ideas of such materials appeared in the XIX century. Such constructions make it possible to obtain a negative permittivity, and further the “invisibility effect”. The idea of creating a material with a given microstructure also makes it possible to obtain metamaterials with a negative Poisson’s ratio, acoustic metamaterials. Separately, it should be noted that such an approach makes it possible to obtain metamaterials with negative rigidity and vibration-isolating metamaterials. The article presents the author's design of a vibration-isolating metamaterial with quasi-zero stiffness. A demonstration prototype was made.
Üniversite Tanıtımı İçin Web Tabanlı Etkileşimli E-Katalog Uygulaması: Çanakkale Onsekiz Mart Üniversitesi Güzel Sanatlar Fakültesi Tanıtım Kataloğu Örneği
Authors: Çatal Didem , Çam Semra
Published: June 2023

Günümüzde dijital teknolojilerin yaygınlaşması ile internet ve mobil cihazlar aracılığıyla iletişim kurmak ve bilgiye erişmek daha da kolaylaşmıştır. Bu durum, üniversiteli gençlerin iletişim ve bilgiye erişim alışkanlıklarını da etkilemiştir. Üniversiteli gençler, özellikle görsel odaklı etkileşimden faydalanarak, internet üzerinden iletişim kurmaktadırlar. Bu nedenle, üniversite ve fakültelerin tanıtımları için dijital çağın gerekliliklerine uygun olarak interaktif e-katalogları, önemli bir iletişim aracı olarak gündeme gelmektedir.

Bu çalışmada, Çanakkale Onsekiz Mart Üniversitesi Güzel Sanatlar Fakültesi'nin interaktif tanıtım kataloğu üzerinden üniversite tanıtımının gerekliliği ele alınmıştır. Çalışmanın amacı, üniversite tanıtım e-kataloglarının; arayüz tasarımı, işlevselliği, içeriği, bilgiye erişimi, kullanıcı kolaylığı ve deneyimi, interaktif özelliği kapsamında incelenmesidir. Çalışma nitel araştırma yöntemi kapsamında üniversitelerin web siteleri taranarak e-katalog kullanan üniversite ve fakültelerden seçilen örnekler üzerinden analiz yapılarak gerçekleşmiştir. İnteraktif tanıtım e-katalogları ve üniversite tanıtımı konularına ilişkin literatür taramasının yanı sıra nicel gözleme dayalı bir anket uygulaması yapılarak elde edilen bulgular ile bu alana katlı sağlayacak bir kaynak sağlamak hedeflenmiştir.
Trace Elements in the Meat and Internal Organs of the Mountain Hare (Lepus timidus L., 1758) in the North of the Krasnoyarsk Region
Authors: Kochkarev Pavel , Koshurnikova Maria , Sergeyev Alexey , Shiryaev Valery
Published: June 2023

Relevant data on trace elements and toxic metals in game meat make it possible to monitor chemical pollution, as well as to detect risks to human and animal health.

The authors used atomic absorption spectrometry to study iron, copper, zinc, lead, and cadmium in the skeletal muscles, liver, and kidneys of mountain hares (Lepus timidus L.) (n = 107). The animals were caught during two seasons on reference sites and technogenic territories in the northern Krasnoyarsk Region.

The samples obtained from the hares that lived on the reference sites had a much lower content of toxic metals. The tissues that belonged to the hares from the polluted habitats contained more lead and cadmium while the samples from the reference sites demonstrated traces of such biogenic elements as copper, zinc, and iron. The differences may be associated with the antagonism of biogenic elements and toxic metals in the body. The correlations between various metals probably meant that they came from one and the same pollution source.

The levels of cadmium and lead in the samples from the technogenic areas were not hazardous to animal health. However, their meat and liver were unfit to eat. Therefore, hunting in the areas of technogenic pollution can pose a toxic hazard to indigenous hunters and their families.
Cold Atmospheric Gas Plasma Processing of Apple Slices
Authors: Sosnin Maxim , Shorstkii Ivan
Published: June 2023

The food industry needs more effective drying procedures that would maintain the quality of the original fruit or vegetable. Infrared drying combined with advanced electrophysical technologies may be a perfect solution. The present research objective was to study the effect of low-temperature atmospheric gas plasma treatment on the drying efficiency of apple slices.

The research featured apples of the Idared variety (Russia) sliced into pieces of 5, 7, and 10 mm. The experiment involved the parameters of drying kinetics and moisture diffusion. The quality of the apple slices was assessed by the total content of phenols and flavonoids, generalized antiradical activity, color characteristics, and the Fourier transform infrared (FT-IR) spectrum.

The electropores induced by the cold atmospheric gas plasma processing had a tree-like structure. The pre-treatment reduced the drying time by 18.0, 13.0 and 10.5% for the samples with a thickness of 5, 7, and 10 mm, respectively. The specific energy consumption decreased by 15–18%, depending on the slice thickness. The pre-treatment also increased the total content of phenols, flavonoids, and antiradical activity by 2.5–14.3, 19.1–25.9, and 8.3–35.4%, respectively.

Therefore, the pre-treatment with cold atmospheric gas plasma reduced the drying time and preserved the original biologically active compounds in dried apple slices.
A comprehensive field investigation of the dynamic break-up processes on the Chaudière River, Quebec, Canada
Authors: Ghobrial Tadros , Pelchat Gabriel , Morse Brian
Published: June 2023

The Chaudière River in Quebec, Canada, is well known for its frequent ice jam flooding events. As part of a larger watershed research program, an extensive field campaign has been carried out during the 2018–2019 and 2019–2020 winter seasons to quantify the spatiotemporal characteristics of the break-up processes along the Chaudière River. The results showed that mid-winter ice jams have formed in the Intermediate Chaudière and persisted until spring break-up. Spring break-ups were initiated in the Upper Chaudière, and then, almost simultaneously, in the Intermediate and Lower Chaudière reaches. The break-up in the Intermediate Chaudière usually lasts longer than the rest of the river since the slope is much milder, and the occurrence of mid-winter ice jams has been seen to delay the ice clearing. A reach-by-reach characterization of the cumulative degree day of thawing and discharge thresholds for the onset of break-up has been identified. During the field campaign, 51 ice jams were documented together with their location, length, date of formation, and the morphological feature triggering jam formation. Break-up patterns, hydrometeorological thresholds of ice mobilization, and ice jam sites identified in this study can serve as a basis for the implementation of an early warning system.
A H2O2-free heterogeneous Fenton process for the degradation of lincomycin using natural structural iron-containing clay mineral and dimethoxyhydroquinone with in situ generated hydroxyl radicals
Authors: Huang Jian , Zhang Yifan , Gao Zhicheng , Wang Yi , Wei Jiayi , Zhang Zhiyuan
Published: June 2023

The heterogeneous Fenton process is a strategy for overcoming the greatest shortcomings of traditional homogeneous Fenton, i.e. the high generation of ferric hydroxide sludge and effectivity in a limited pH range. In this study, we constructed a heterogeneous Fenton system with natural iron-bearing clay mineral (nontronite) and dimethoxyhydroquinone (DMHQ) to degrade lincomycin (LCM) without the addition of H2O2. The degradation mechanism was derived from the hydroxyl radicals (•OH) produced from the oxygenation of Fe(II) in nontronites, which was reduced by DMHQ. Acidic conditions and low concentrations of LCM were favourable for LCM degradation. When the solution pH increased from 3 to 7, the final LCM removal ratio decreased from 95 to 46%. However, LCM can still be degraded by 46% under neutral conditions and 20% at the LCM concentration of 500 μmol/L. The nontronite has good reusability, and the LCM degradation efficiency in the fourth cycle still exceeded 90% of the original efficiency. The degradation sites of LCM mainly occurred in the methyl thioether moiety and the aliphatic amine group on the pyrrolidine ring, with the final product of CO2. This research presents a new eco-friendly and cost-effective method for the heterogenous Fenton process without external H2O2.
Novel Perspectives on Nanotechnological and Biomedical Implications of
Monotherapy or Combination Regimen of Lactoferrin
Authors: Chen Kuo , Zhang Jin , Beeraka Narasimha M. , Li Jialing , Sinelnikov Mikhail Y. , Zhang Xinliang , Cao Yu , Zakharova Darya K. , Nikolenko Vladimir N. , Reshetov Igor V. , Lu Pengwei
Published: June 2023

Lactoferrin (LF) is a protein molecule with a wide variety of physiological properties. LF has broadspectrum
antibacterial, antiviral, antioxidant, and antitumor, and possesses immunomodulatory properties to regulate
immunity and gastrointestinal function. The main aim of this review is to explore the recent investigations
on the functional role of LF against several human disorders and diseases through monotherapy or combinatorial
regimens with other biological/chemotherapeutic agents through novel nanoformulations. We significantly
searched public databases such as Pubmed, National Library of Medicine, relemed, Scopus and collected published
reports pertaining to these recent reports on lactoferrin as a monotherapy or combination therapy, and its
nanoformulations. We have discussed vividly the role of LF as a growth factor with substantial potential that
can promote cell growth and regeneration potential for repairing tissues such as bone, skin, mucosa, and tendons.
In addition, we have discussed novel perspectives on the role of LF as an inductive factor for the proliferation
of stem cells in tissue recovery and discussed its novel modulating effects in ameliorating cancer and microbial
growth through several signaling cascades via monotherapy or combinatorial regimens. Furthermore, the regeneration
potential of this protein is reviewed to explore the efficacy and prospects of new treatment methods.
This review benefits various microbiologists, stem cell therapists, and oncologists to explore the efficacy of LF
in several segments of medicine by examining its ability as a stem cell differentiation factor, and anticancer
agent or antimicrobial agent through novel formulations in preclinical or clinical study.
Improved Antitumor Efficacy of a Dextran-based Docetaxel-coupled
Conjugate against Triple-Negative Breast Cancer
Authors: Lv Hongshuai , Jia Weiping , Dong Peng , Liu Jiaojiao , Wang Si , Li Xiaohai , Hu Jinghua , Zhao Ling , Shi Yikang
Published: June 2023

Background:

Most chemotherapeutic agents are characterized by poor water solubility and
non-specific distribution. Polymer-based conjugates are promising strategies for overcoming these limitations.

Objective:

This study aims to fabricate a polysaccharide, dextran-based, dual-drug conjugate by covalently
grafting docetaxel (DTX) and docosahexaenoic acid (DHA) onto the bifunctionalized dextran
through a long linker, and to investigate the antitumor efficacy of this conjugate against breast cancer.

Methods:

DTX was firstly coupled with DHA and covalently bounded with the bifunctionalized dextran
(100 kDa) through a long linker to produce a conjugate dextran-DHA-DTX (termed C-DDD). Cytotoxicity
and cellular uptake of this conjugate were measured in vitro. Drug biodistribution and pharmacokinetics
were investigated through liquid chromatography/mass spectrometry analysis. The inhibitory
effects on tumor growth were evaluated in MCF-7- and 4T1-tumor-bearing mice.

Results:

The loading capacity of the C-DDD for DTX was 15.90 (weight/weight). The C-DDD
possessed good water solubility and was able to self-assemble into nanoparticles measuring 76.8 ± 5.5
nm. The maximum plasma concentration and area under the curve (0-∞) for the released DTX and total
DTX from the C-DDD were significantly enhanced compared with the conventional DTX formulation.
The C-DDD selectively accumulated in the tumor, with limited distribution was observed in normal
tissues. The C-DDD exhibited greater antitumor activity than the conventional DTX in the triplenegative
breast cancer model. Furthermore, the C-DDD nearly eliminated all MCF-7 tumors in nude
mice without leading to systemic adverse effects.

Conclusion:

This dual-drug C-DDD has the potential to become a candidate for clinical application
through the optimization of the linker.
Stability Indicating Analytical Method, Characterization of Degradation
Impurity by UPLC-Q-TOF-MS/MS, and Establishment of Degradation
Mechanism of Evodiamine
Authors: Adye Daya Raju , Sahu Amit Kumar , Rajput Niraj , Panday Niraj Kumar , Sengupta Pinaki
Published: June 2023

Aim:

The current research aims to establish a stability-indicating analytical method (SIAM) for
the quantification of evodiamine (EVO), characterization of its degradation impurity, and establishment
of possible degradation pathways.

Background:

None of the degradation impurities of EVO is known and the mechanism of their formation
has not been reported in any literature to date. Moreover, a SIAM for EVO is not available in any public
domain.

Objective:

The objective of this study is to characterize the degradation impurity of EVO by LC-MS/MS,
proposing its molecular structure, identifying possible degradation pathways of generation of its impurity,
and establishing a SIAM.

Method:

To assist future product development, a degradation study of EVO was performed and an RPHPLC-
based SIAM was developed. The major degradation product was characterized by LC-Q-TOFMS/
MS. In addition, in silico toxicity prediction was performed using the ProTox-ІI toxicity predictor.

Result:

The method was found to be linear, accurate, precise, and robust over the range of 12.5 to 100 μg
/mL of EVO. The method met all the acceptance criteria as specified in the ICH guideline. Only one degradation
product (9% of the drug area) of EVO was generated in acidic hydrolytic conditions. The degradation
product was found to be potentially inactive for hepatotoxicity and immunotoxicity, with a confidence
score of more than 0.7 (70%). Moreover, the confidence score for carcinogenicity, mutagenicity,
and cytotoxicity was less than 0.7, indicating it was moderately inactive for these toxicities.

Conclusion:

The molecule was found to be stable in the majority of the tested stress conditions. However,
the degradation product generated in acidic hydrolytic stress was characterized using LC-Q-TOF-MS/MS,
which was unknown to date. The novelty of this research can be justified by the unavailability of any
SIAM of EVO and the absence of any report on its susceptibility to degradation in the presence of different
potential stressors. Moreover, the potential toxicity of the molecule and its impurity was not known
previously. The reported degradation impurity may be useful to set the quality control acceptance criteria
for EVO. Additionally, pharmaceutical industries and research laboratories may use the developed method
for the analysis of quality control and stability samples of EVO.
Casein Kinase 2 Affects Epilepsy by Regulating Ion Channels: A Potential
Mechanism
Authors: Liu Yan , Xia Di , Zhong Lianmei , Chen Ling , Zhang Linming , Ai Mingda , Mei Rong , Pang Ruijing
Published: June 2023

Epilepsy, characterized by recurrent seizures and abnormal brain discharges, is the third most common chronic disorder of the Central Nervous System (CNS). Although significant progress has been made in the research on antiepileptic drugs (AEDs), approximately one-third of patients with epilepsy are refractory to these drugs. Thus, research on the pathogenesis of epilepsy is ongoing to find more effective treatments. Many pathological mechanisms are involved in epilepsy, including neuronal apoptosis, mossy fiber sprouting, neuroinflammation, and dysfunction of neuronal ion channels, leading to abnormal neuronal excitatory networks in the brain. CK2 (Casein kinase 2), which plays a critical role in modulating neuronal excitability and synaptic transmission, has been shown to be associated with epilepsy. However, there is limited research on the mechanisms involved. Recent studies have suggested that CK2 is involved in regulating the function of neuronal ion channels by directly phosphorylating them or their binding partners. Therefore, in this review, we will summarize recent research advances regarding the potential role of CK2 regulating ion channels in epilepsy, aiming to provide more evidence for future studies.
Clinical-surgical Characteristics of Patients with Macular Hole. Exilaser Ophthalmological Center. Cuenca, Ecuador. 2015-2019
Authors: Montesinos Giuseppe Miotto , Rojas Alvarez Eduardo , Cabrera Susana Teresa Guerrero , Márquez Marchán Andrea Carolina , Urias Naima Pino
Published: June 2023

Background:

The macular hole (MH) is one of the least studied ophthalmological pathologies; satisfactory treatment has been achieved through the implementation of surgical techniques a few years ago and the study and analysis of its clinical-surgical characteristics are of vital importance to assess the success of surgery with intrinsic and extrinsic factors.

Objective:

Describe the clinical-surgical characteristics of patients diagnosed with a macular hole at the EXILASER Ophthalmological Center in Cuenca in the period 2015-2019.

Methods:

Descriptive, retrospective study. The study universe corresponds to 75 patients who attended the EXILASER Ophthalmological Center and were diagnosed with MH between January-2015 and December-2019.

Results:

76.0% of the patients are women; 81.3% are between 60 and 79 years old; 96.0% reside in urban areas; 34.7% are dedicated to housework; 24.0% report cataracts; 26.7% have arterial hypertension; 84.0% presented loss of central vision; 80.0% had decreased visual acuity. 50.7% presented affection only in the right eye; 53.3% had a chronic evolution greater than one year; 33.3% presented grade III MH. 44.0% had surgery; 93.9% had anatomical surgical closure. The relationship between the degree of MH, time of evolution, and closure of the MH was not significant (p> 0.05).

Conclusion:

The success rate of MH closure after surgical intervention is greater than 90% with improvement in postoperative visual acuity. No significant association was found between the grade of the MH, time of evolution, and the closure of the MH.
Reconfiguration of Low Voltage Electricity at Micro Hydro Power Plant (MHP) in Andungbiru
Authors: Utomo Teguh
Published: June 2023

Electricity is a means to support community activities both in efforts to improve welfare and to encourage economic development. The National Electricity Company (PLN) as the state electricity provider has not been able to reach the electricity network in remote villages. Andungbiru Village, Tiris Subdistrict, Probolinggo Regency is one of the areas that install PLTMH (Micro Hydro Power Plants). Due to the increase in load every year, the current conditions of the PLTMH power grid in Andungbiru village experience a more even distribution of R, S, and T phases in units 1 and 2. This situation causes very large voltage drops and loss of power to the channel so it needs to be configured to reset it. Based on the results of network configuration, phase voltage R, S, and T in unit 1 is 7,9136% V, 5,9599% V, and 6,4707% V which was previously 22,3385% V, 18,0570% V, and 47,3622% V. The results of reconfiguring unit 2 networks for falling phase voltage R, S, and T are 2,6957% V, 1,4909% V, and 0,8985% V which were previously 7.3672% V, 17,2237% V, and 13,8929% V. The power loss in unit 1 after reconfiguring the network is 2873,3886 Watts which was previously 20910,9708 Watts and in unit 2 after reconfiguring the network is 221,0193 Watts which is 1749,6933 Watts. The results of network reconfiguration can reduce voltage drop and power loss in low-voltage networks and follow the standard that the maximum voltage drop is 10% of the nominal voltage of 220V.
Text to Speech Using Finite State Automata on Health Data
Authors: Indrianto Indrianto , Abdurrasyid Abdurrasyid , Nur Indah Susanti Meilia , Fairus Ferdiansyah Deu Givari , Ramadhan Arief
Published: June 2023

Computer science and engineering has provided many benefits that can be applied in our lives, such as in the field of automata theory, one of the largest areas related to the efficiency of an algorithm in solving problems in computational models. Text to Speech is a technology that converts text into sound using a phonetization system, phonemes that are arranged to form a speech to make computers able to communicate and interact with everyday spoken language. Data that need to be interpret is the health data such as body temperature, heart rate per minute, and oxygen levels. Text to Speech is very useful to be applied to blind aids who need information in the form of sound because of their limitations. For this reason, it is necessary to make an application that can read text-based data that is stored into a voice that can be heard by the blind, the method used in this study is Finite State Automata (FSA) which is used to split Indonesian words into words according to its syllable patterns and facilitate the pronunciation process which is included in the blind aids so that it is expected to help the visually impaired to be able to find out their health condition. in this study, the test was carried out using the Confusion Matrix method, while the results obtained were 97% accurate.
Internet of Things-based Cow Body Weight Recording System
Authors: Trilaksana Citra , Akbartama Effan , Muttaqin Adharul , Setyawati Onny
Published: June 2023

Internet of Things (IoT) can be applied to various aspects, especially it can be used as a system for recording, storing, sorting, and processing data. This application can be used in a cattle body weight recording system. Recording is all types of record activities such as identification activities, genealogical records, production and reproduction records, maintenance management records and livestock health records in certain populations. In the process of fattening cattle, recording is an essential activity, but in a survey conducted at the Sumber Sekar laboratory of the Faculty of Animal Husbandry, Universitas Brawijaya, a problem was found, namely the availability of cattle scales for the recording process. For this reason, an internet of things-based cow body weight recording system was designed. The internet of things-based cow body weight recording system uses 2 Load Cell sensors to weigh the cow's body weight and an RFID sensor to read the cow's identity, in addition to the sensor the system has a website as a user interface. It is hoped that this application can improve the efficiency of the cow body weight recording process and produce an intelligent tool system.
Development of Sustainable Regional Innovation Towards Gemilang Tangerang Regency: Study in the Tangerang Regency
Authors: Ramadhan Arif , Syah Ardy Firman , Plamonia Nicco , Andreani Selfy , Yohanitas Witra Apdhi
Published: June 2023

The development of sustainable regional innovation is a step taken in realizing Tangerang Gemilang Regency. Tangerang Gemilang branding introduces regional potentials, such as tourism, industry, agriculture, and culture. Through sustainable innovation, regional development programs develop the superior potentials in the region more efficiently and effectively to increase regional competitiveness and positively impact society. This research aims to identify sustainable innovations that have been implemented by the Tangerang Regency Government, as well as to analyze the factors that influence the successful development of these innovations. The novelty of the research lies in the discussion of the implementation of regional innovations in the Tangerang Regency that have been carried out sustainably. The research discusses various aspects of sustainable regional innovations, including tourism, technology, infrastructure, and community participation. The research has an explanatory nature with a qualitative approach and a single case study where data is collected through in-depth interviews, observation, document analysis, and descriptive data processing. Then the independent variables (brand awareness, product innovation, number of new products, regional identity) and dependent variables (tourist attraction, industry, trade) were analyzed. The research found that implementing sustainable regional innovation to realize the branding of the Tangerang Gemilang district has been stated in the 2019-2014 RPJMD. Realizing Tangerang Gemilang with a sustainable innovation ecosystem requires a participatory and collaborative approach. Collaboration makes the ecosystem develop and have an impact. The importance of the innovation ecosystem is to reduce progressive programs that are often stopped when there is a change of regional head or mutation of regional apparatus leaders. Sustainability requires technical and policy innovation as well as a philosophical foundation in the form of city branding with careful planning. Tangerang Regency has proven this through policy preparation, mentoring and comprehensive evaluation of innovative programs to realize Tangerang Gemilang.
Radicalisation des jeunes : Menaces et opportunités depuis la crise sanitaire liée au coronavirus
Authors: Ponciau Cyprien
Published: June 2023

Directement concernée parles attentats terroristes de Paris et Bruxelles, Sambreville a dû, en plus dela création d’une CSIL-R, construire un réseau d’acteurs de terrain formés àregarder la radicalisation comme un phénomène en constante mutation. Avec lacrise sanitaire liée au covid, les partenaires locaux du secteur de la jeunesseont très vite fait le constat que la santé mentale des jeunes s’était dégradéeet pourrait, à terme, amener certains jeunes vers des comportements violentspour eux-mêmes et pour les autres, y compris en termes de risque d’entrée dansun processus de radicalisation violente qui est, peut-être, plus difficile à détecterdepuis le covid. A Sambreville, les actions mises en place au niveau local enfaveur du bien-être mental des jeunes permettent aux intervenants sociauxd’agir chacun dans leur sphère de compétence en associant la cohésion sociale,la prévention des problèmes généraux mais aussi des risques spécifiques commele processus de radicalisation.
Learning from the enemy? Jihadist power in Mali, and implications for security and development agendas
Authors: Ladini Gianfabrizio
Published: June 2023

This article explores howviolent jihadist groups structure and expand their presence in Mali, and itsuggests some policy implications for security and development. A theoreticalframework is presented that combines rebel governance literature, with specialreference to so-called jihadist proto-states, with an analysis of powerrevolving around three dimensions: cultural hegemony, political dominion, andforce. This framework is applied to Mali. The complex galaxy of militant groupsoperating in the country is briefly introduced, with their coalitions andfragmentation, and the consequences of their activities on community securityand livelihoods are outlined. An embryonic theory follows, that accounts forhow militants project power and exert control over communities: not only withviolence, but also through ideological struggles and service delivery. Jihadistsuccesses, in Mali and beyond, largely result from skilful applications ofthese 3 dimensions of power, different yet mutually reinforcing. Policies aimedat countering violent jihad should likewise target all the 3 dimensions bygoing beyond armed counterterrorism, by engaging jihadists in ideological debates,and by promoting better forms of governance.
Colofon
Authors: Outreach OCAD/OCAM
Published: June 2023

Colofon/colophon
Redactieraad
Authors: Outreach OCAD/OCAM
Published: June 2023

Redactieraad/Comité de rédaction
Digital Education for the Deployment of Artificial Intelligence in Health Care
Authors: Malerbi Fernando Korn , Nakayama Luis Filipe , Gayle Dychiao Robyn , Zago Ribeiro Lucas , Villanueva Cleva , Celi Leo Anthony , Regatieri Caio Vinicius
Published: June 2023

Artificial Intelligence (AI) represents a significant milestone in health care's digital transformation. However, traditional health care education and training often lack digital competencies. To promote safe and effective AI implementation, health care professionals must acquire basic knowledge of machine learning and neural networks, critical evaluation of data sets, integration within clinical workflows, bias control, and human-machine interaction in clinical settings. Additionally, they should understand the legal and ethical aspects of digital health care and the impact of AI adoption. Misconceptions and fears about AI systems could jeopardize its real-life implementation. However, there are multiple barriers to promoting electronic health literacy, including time constraints, overburdened curricula, and the shortage of capacitated professionals. To overcome these challenges, partnerships among developers, professional societies, and academia are essential. Integrating specialists from different backgrounds, including data specialists, lawyers, and social scientists, can significantly contribute to combating digital illiteracy and promoting safe AI implementation in health care.