bluuebunny/crossref_metadata_2025 huggingface dataset:
Frailty Predicting Health-Related Quality of Life Trajectories in Individuals with Sarcopenia in Liver Cirrhosis: Finding from BCAAS Study
Authors: Nathiya Deepak , Raj Preeti , Singh Pratima , Bareth Hemant , Tejavath Arun Singh , Suman Supriya , Tomar Balvir Singh , Rai Ramesh Roop
Published: August 2023

The association between frailty and health-related quality of life (HRQoL) among Asian patients with liver cirrhosis and sarcopenia remains largely unexplored. To address this knowledge gap, we conducted a cross-sectional study involving individuals aged 32 to 69 years, all diagnosed with liver cirrhosis. The chronic liver disease questionnaire (CLDQ) was used to assess HR-QoL, the CLDQ score was used as an outcome to measure the factors related to HR-QoL, and the liver frailty index (LFI) was used to assess the frailty status. The association between the frailty status and the CLDQ summary scales was investigated using the correlation coefficient and multiple regression analyses. A total of 138 patients in the frail (n = 62) and non-frail (n = 76) groups with (alcohol: 97; viral: 24; autoimmune: 17; and cryptogenic: 12) were included in the study. Age, CTP score, and model for end-stage liver disease (MELD) sodium were significantly higher in the frail group. In the CLDQ domains, there was a significant difference between the frail and non-frail groups (p value = 0.001). In health-related quality-of-life summary measures, there was a strong negative correlation between frailty and the scores for activities, emotional function, and fatigue (p value = 0.001). When comparing frail to non-frail patients, these characteristics demonstrated significantly increased odds as indicated by their adjusted odds ratios: OR 3.339 (p value = 0.013), OR 3.998 (p value = 0.006), and OR 4.626 (p value = 0.002), respectively.
Comparison of MRI vs. [18F]FDG PET/CT for Treatment Response Evaluation of Primary Breast Cancer after Neoadjuvant Chemotherapy: Literature Review and Future Perspectives
Authors: Caracciolo Matteo , Castello Angelo , Urso Luca , Borgia Francesca , Marzola Maria Cristina , Uccelli Licia , Cittanti Corrado , Bartolomei Mirco , Castellani Massimo , Lopci Egesta
Published: August 2023

The purpose of this systematic review was to investigate the diagnostic accuracy of [18F]FDG PET/CT and breast MRI for primary breast cancer (BC) response assessment after neoadjuvant chemotherapy (NAC) and to evaluate future perspectives in this setting. We performed a critical review using three bibliographic databases (i.e., PubMed, Scopus, and Web of Science) for articles published up to the 6 June 2023, starting from 2012. The Quality Assessment of Diagnosis Accuracy Study (QUADAS-2) tool was adopted to evaluate the risk of bias. A total of 76 studies were identified and screened, while 14 articles were included in our systematic review after a full-text assessment. The total number of patients included was 842. Eight out of fourteen studies (57.1%) were prospective, while all except one study were conducted in a single center. In the majority of the included studies (71.4%), 3.0 Tesla (T) MRI scans were adopted. Three out of fourteen studies (21.4%) used both 1.5 and 3.0 T MRI and only two used 1.5 T. [18F]FDG was the radiotracer used in every study included. All patients accepted surgical treatment after NAC and each study used pathological complete response (pCR) as the reference standard. Some of the studies have demonstrated the superiority of [18F]FDG PET/CT, while others proved that MRI was superior to PET/CT. Recent studies indicate that PET/CT has a better specificity, while MRI has a superior sensitivity for assessing pCR in BC patients after NAC. The complementary value of the combined use of these modalities represents probably the most important tool to improve diagnostic performance in this setting. Overall, larger prospective studies, possibly randomized, are needed, hopefully evaluating PET/MR and allowing for new tools, such as radiomic parameters, to find a proper place in the setting of BC patients undergoing NAC.
Examining the Decoupling of Economic Growth with Land Expansion and Carbon Emissions in Zhejiang Province, China
Authors: Li Zepan , Lu Zhangwei , Xu Lihua , Shi Yijun , Ma Qiwei , Wu Yaqi , Cao Yu , Sheng Boyuan
Published: August 2023

Coordinating the interrelationships among economic growth, land resource utilization, and carbon emissions is critical for promoting high-quality economic growth and achieving sustainable urban progress. According to the gravity model and the Tapio decoupling model, this study examined the decoupling relationships of economic growth with land expansion and carbon emissions in Zhejiang Province during the period of 2002–2017. We found that (1) The economic gravity center and the built-up area gravity center generally shifted towards the northwest; however, the carbon emission gravity center initially shifted towards the northwest and then towards the southwest. The spatial coupling between the economic gravity center and the built-up area gravity center exhibited a tendency of ‘first weakening, then strengthening, and last weakening’, whereas the spatial coupling between the economic gravity center and the carbon emission gravity center displayed a tendency of ‘first strengthening and then weakening’. (2) The decoupling of economic growth and land expansion is weak at every stage with effective controls on land expansion. However, in recent years, the phenomenon of ‘expansive negative decoupling’ has become prevalent in counties and cities surrounding the central city. The decoupling of economic growth and carbon emissions steadily increased at each stage, first ‘expansive coupling and expansive negative decoupling’, then ‘weak decoupling’, and finally ‘strong decoupling’. The urban low-carbon transformation effect is remarkable. (3) Zhejiang Province should prioritize addressing the regional imbalance and state instability in the decoupling relationships. It is crucial to comprehensively consider the natural resource endowment, macro-policy factors, and urban development orientation of counties and cities while implementing differentiated planning and control strategies, which will promote regional coordination and comprehensive, high-quality development in all areas.
Cardiovascular Mortality in Ovarian Cancer Patients: An Analysis of Patient Characteristics Using the SEER Database
Authors: Al-Badawi Ismail Abdulrahman , Alomar Osama , Alsehaimi Saud Owaimer , Jamjoom Mohammed Ziad , Abdulmalik Nadia Ahmed , Bukhari Ibtihal Abdulaziz , Alyousef Abdullah , Alabdrabalamir Safa , Baradwan Saeed , Sayasneh Ahmad , Alqarni Saad M. S. , Abu-Zaid Ahmed
Published: August 2023

Background and Objectives: Cardiovascular disease (CVD) is a major contributor to the high mortality rate among individuals with ovarian cancer. Nevertheless, there is limited understanding regarding the specific patient attributes that might impact the risk of CVD in this group. Materials and Methods: A retrospective cohort study was performed using the SEER database to analyze primary ovarian cancer cases from 2000 to 2019. Multivariable logistic regression analysis was employed to identify patient characteristics linked to cardiovascular mortality. Results: The cohort included 41,930 cases of patients who were alive, 54,829 cases of cancer-related deaths, 3003 cases of cardiovascular-related deaths, and 10,238 cases with other causes of death. Poorly differentiated cancer cells and distant metastasis were associated with a higher risk of cardiovascular mortality. Logistic regression analysis identified age, year of diagnosis, race, laterality, and staging as significant risk factors for cardiovascular cause of death. The risk of cardiovascular cause of death was lower in patients aged 31–60 and higher in those aged over 60 years old, and the risk also increased with a later year of diagnosis. Patients who were not white were at a higher risk of cardiovascular cause of death. Additionally, bilateral ovarian cancer and distant staging disease were linked to elevated risks of cardiovascular cause of death. Conclusion: Cardiovascular mortality is a significant concern in ovarian cancer patients, and several patient characteristics are associated with an increased risk. Our study suggests that targeted interventions to improve cardiovascular health in high-risk patients, such as those with comorbidities or an advanced stage at diagnosis, may improve survival in this population.
Design and Additive Manufacturing of a Continuous Servo Pneumatic Actuator
Authors: Dämmer Gabriel , Bauer Hartmut , Lackner Michael , Neumann Rüdiger , Hildebrandt Alexander , Major Zoltán
Published: August 2023

Despite an emerging interest in soft and rigid pneumatic lightweight robots, the pneumatic rotary actuators available to date either are unsuitable for servo pneumatic applications or provide a limited angular range. This study describes the functional principle, design, and manufacturing of a servo pneumatic rotary actuator that is suitable for continuous rotary motion and positioning. It contains nine radially arranged linear bellows actuators with rollers that push forward a cam profile. Proportional valves and a rotary encoder are used to control the bellows pressures in relation to the rotation angle. Introducing freely programmable servo pneumatic commutation increases versatility and allows the number of mechanical components to be reduced in comparison to state-of-the-art designs. The actuator presented is designed to be manufacturable using a combination of standard components, selective laser sintering, elastomer molding with novel multi-part cores and basic tools. Having a diameter of 110 mm and a width of 41 mm, our prototype weighs less than 500 g, produces a torque of 0.53 Nm at 1 bar pressure and a static positioning accuracy of 0.31° with no limit of angular motion. By providing a description of design, basic kinematic equations, manufacturing techniques, and a proof of concept, we enable the reader to envision and explore future applications.
Antibacterial Potency of an Active Compound from Sansevieria trifasciata Prain: An Integrated In Vitro and In Silico Study
Authors: Kasmawati Henny , Ruslin Ruslin , Arfan Arfan , Sida Nurramadhani A. , Saputra Dimas Isnu , Halimah Eli , Mustarichie Resmi
Published: August 2023

Sansevieria trifasciata Prain holds great potential as a valuable asset in pharmaceutical development. In this study, our focus is to explore and assess the antibacterial activity of various components derived from this plant, including extracts, fractions, subfractions, and isolates, explicitly targeting two common bacteria: Escherichia coli and Streptococcus aureus. The isolated compound, identified as a derivative pyridone alkaloid (5-methyl-11-(2-oxopyridin-1(2H)-yl)undecaneperoxoicacid), demonstrates notable antibacterial effects. The extracts, fractions, subfractions, and isolates reveal significant bacterial growth reductions (p < 0.05). The minimum inhibitory concentration (MIC) values for Escherichia coli were 1.95 ppm, 3.9 ppm, 15.62 ppm, and 7.81 ppm, respectively, while the MIC values for Streptococcus aureus were 1.95 ppm, 1.95 ppm, 15.62 ppm, and 7.81 ppm, respectively. Computational analysis showed the isolates’ interaction with key residues on the active site of β-ketoacyl-ACP synthase from Escherichia coli and TyrRS from Streptococcus aureus. The findings indicate that the isolates exhibit a strong affinity for specific residues, including His333, Cys163, and Phe392 in β-ketoacyl-ACP synthase, as well as Arg88, His117, Glu160, and Gln213 in TyrRS. Comparative energy calculations using MMPBSA demonstrate the isolates’ favorable binding energy (−104,101 kJ/mol for β-ketoacyl-ACP synthase and −81,060 kJ/mol for TyrRS) compared to ciprofloxacin. The elucidated antibacterial activity and molecular interactions of the isolates present valuable knowledge for future in vitro studies, facilitating the development of novel antibacterial agents targeting diverse bacterial strains.
Theoretical Insights into a Near-Infrared Fluorescent Probe NI-VIS Based on the Organic Molecule for Monitoring Intracellular Viscosity
Authors: Peng Yongjin , Huang He , Liu Yuling , Zhao Xiaoyan
Published: August 2023

So many biological functional disorders and diseases, such as atherosclerosis, hypertension, diabetes, Alzheimer’s disease, as well as cell malignancy are closely related with the intracellular viscosity. A safe and effective intracellular viscosity detecting method is desired by the biomedical community. Recently, a novel near-infrared fluorescent probe NI-VIS with a twisting intramolecular charge transfer mechanism was developed. The capability of this probe to visualize the viscosity variation in cirrhotic liver tissues and map the micro viscosity in vivo were testified using an experiment. In this work, the twisting intramolecular charge transfer mechanism and fluorescent properties of the probe NI-VIS were studied in detail under quantum mechanical method. The low energy barrier among the different conformations of the probe indicated the occurrence of twisting intramolecular charge transfer due to the rotation of the aryl group in the probe molecule while within the low viscosity environment. The electronic structure analysis on different probe conformations revealed the electron transfer process of the probe under optical excitation. All these theoretical results could provide insights into understand in greater depth the principles and build highly effective fluorescent probe to monitor the viscosity in biological samples.
Teaching about Culture or Learning with and from Others?
Authors: Ciabatti Nataša
Published: August 2023

This article reports on the findings of a qualitative study conducted in Victoria, Australia. The study examined the perceptions and implementation of the intercultural dimension in the language classroom following recent curriculum changes. Data were collected from individual in-depth interviews with seven pre-service teachers with a migrant background enrolled in a graduate initial teacher education program who were undertaking the practicum component of this course in Victorian secondary schools. Findings from this study highlight discrepancies between interpretations of the intercultural capability in theory and the way it is taught. Remarkably, what emerged was the impact of personal experiences on pre-service teachers’ conceptualizations and implementation of intercultural pedagogies. This study suggests a new definition for intercultural capability that emphasizes the importance of not only teaching about cultural diversity, but also learning from and through it. The study also recognizes the need for critical and reflective discussions in teacher education so that teachers are supported to become agents of change.
West Nile Virus Lineage 2 in Free-Living Corvus cornix Birds in Poland
Authors: Niczyporuk Jowita S. , Kozdrun Wojciech , Czujkowska Agnieszka , Blanchard Yannick , Helle Mariteragi , Dheilly Nolwenn M. , Gonzalez Gaelle
Published: August 2023

The summer temperatures recorded in Poland in 2022 were among the highest in over 30 years and, combined with higher-than-expected rainfall, gave the impression of an almost tropical climate. Such climatic conditions were ideal for the transmission of vector-borne zoonotic diseases such as West Nile fever. In northeastern Poland, in the Mazowieckie region, the Polish event-based surveillance network reported increased fatalities of free-living hooded crows (Corvus corone cornix). West Nile virus (WNV) lineage 2 was identified for the first time as the etiological agent responsible for the death of the birds. WNV was detected in 17 out of the 99 (17.17%) free-living birds tested in this study. All the WNV-infected dead birds were collected in the same area and were diagnosed in September by the NVRI and confirmed by the EURL for equine diseases, ANSES, in October 2022. Unnaturally high temperatures recorded in Poland in 2022 likely favored the infection and spread of the virus in the avian population. A nationwide alert and awareness raising of blood transfusion centers and hospitals was carried out to prevent human infections by WNV.
Spatial and Temporal Analysis of Drought Forecasting on Rivers of South India
Authors: Shaikh Ayub , Sharma Kul Vaibhav , Kumar Vijendra , Singh Karan
Published: August 2023

Extreme weather events such as droughts are catastrophic and can have serious consequences for people and the environment. Drought may be managed if measures are taken in advance. The success of this endeavor depends on a number of factors, not the least of which is accurate descriptions and measurements of drought conditions. Reducing the negative consequences of droughts requires an early forecast of drought conditions. The primary objective of this research is, hence, to establish a process for the assessment and prediction of drought. The drought evaluation was carried out using the standards established by the SPI and the Indian Meteorological Department. Maps of drought severity were generated using severe drought data. Thirty years’ worth of SPI readings was analyzed. Fuzzy-based drought forecasting model parameters were determined during a 25-year period, and the model was validated throughout the remaining years. The findings of this study can be used by the community to help combat the drought. Before the drought worsens, the local government can implement lifesaving mitigating measures.
Latinos Safety Behaviors Related to English Literacy as Reported by Dairy Producers in Kewaunee County, Wisconsin
Authors: Opatik Aerica , Novak Mary
Published: August 2023

Safety issues related to low English literacy levels of Latinos on dairy farms are a potential concern to employers. A survey of safety behaviors was completed by 19 dairy producers who employ Latinos in Kewaunee County, Wisconsin. At least two-thirds of the respondents rated five of the 10 safety behaviors as of moderate, high, or extreme concern due to their employees' ability to read, write, speak, or understand English. At least half of the respondents reported providing assistance to employees in functional areas such as housing, law enforcement, and schools. Recommendations for dairies, Extension education, and literacy organization were determined.
Later Life Farming: Retirement Plans and Concerns of Farm Families
Authors: O’Neill Barbara , Komar Stephen , Brumfield Robin , Mickel Robert
Published: August 2023

Many farmers are approaching retirement age and need to take advantage of critical planning years preceding this transition. Farm families often differ from other workers. Many are emotionally attached to their primary investment (farmland), and they don't expect to retire (i.e., stop farming) as much as reduce work hours or the scope of their operation. There is a need for information that addresses the unique retirement planning concerns and mindset of farm families. This article discusses findings from focus groups held with New Jersey farm families (N=13) in 2008 to inform development of an online retirement planning course for farmers.
Advance Directives in Extension Services
Authors: Guinn Keydron
Published: August 2023

Few Extension services have incorporated family planning as an offering to clients. This is particularly true as it relates to advance directives, which are generally viewed as highly sensitive. The Southwest Center for Rural Initiatives (Southwest Center), a satellite entity of the Southern University Agricultural Research and Extension Center, started a program where clientele are offered free, private consultations to gain knowledge on advance directives. This serves as an example of the diversity in programs designed to meet the needs of the community, as well as to improve the quality of life for citizens within the Southwest Center's region.
16. Yüzyıla Ait Bir Tılsım Kitabı ve Söz Varlığı
Authors: BEKAR Beytullah , GÜNGÖR Okan Celal
Published: August 2023

Tılsım, değişik objelerle ve dualarla yapılan bir uygulamadır. Tılsımda insanoğlu doğaüstü güçler yardımıyla amaçlarına kavuşmayı hedefler. Bu amaçlar kimi zaman mal, mülk edinme kimi zaman korkulan şeylerden emin olma kimi zaman bir sevgiliye kavuşma kimi zaman da başka birine zarar verme şeklinde görülür. Çalışmamızın konusunu oluşturan eser, 16. yüzyılda Osmanlı Türkçesiyle yazılmış bir tılsım kitabıdır. Eser, Tübingen’de Eberhard Karls Üniversitesi Kütüphanesinde 10.20345/digitue.25585 numarada dijital olarak kayıtlıdır, toplam 83 varaktan oluşmaktadır. Eserde tılsım yapmak için şu dualar verilmiştir: Dua-yı Bozorg, dua-yı karsiyya, dua-yı azam, dua-yı şerifi’l-mübarek, dua-yı sürh-i bad, dua-yı Muhammet, duaü’n-necat mine’n-nar. Eserde tılsımların niçin ve nasıl uygulanması gerektiğine yönelik bilgiler halkın anlayabileceği şekilde sade bir dille yazılmıştır. Eserdeki hastalık adları, tılsım yaparken kullanılan araç-gereç adları, dinî terimler araştırmacılara zengin bir söz varlığı sunmaktadır. Ayrıca eser teoloji, sosyoloji, halk bilimi gibi farklı bilimsel alanlara da kaynaklık edebilecek niteliktedir. Yapılan inceleme sonucunda halk için yazılmış olan bu eserde, 790 madde başı kelime/kelime grubu tespit edilmiş ve bunların 436’sının Türkçe olduğu görülmüştür.
XVII. Yüzyıl Şairi Beyâzî ve Yayımlanmamış Gazelleri
Authors: TOZLU Musa
Published: August 2023

Şiir mecmuaları, klasik Türk edebiyatı açısından çok önemli kaynaklardır. Keşfedilmeyi bekleyen çok sayıda şair ve eseri içerisinde barındırmaları, bu önemin başlıca sebeplerindendir. Bu durum araştırmacıların ilgisini çekmekte ve buna bağlı olarak da şiir mecmuaları üzerine yapılan çalışmaların sayısı her geçen gün artmaktadır. Bu çalışmalar neticesinde, yayımlanmış divanlarda yer almayan çok sayıda şiir gün yüzüne çıkarken, biyografik kaynaklarda sadece isimleri zikredilen fakat eser örneklerine rastlanılmayan çok sayıda şair ve eseri de ilim dünyasına tanıtılmaktadır.

Bu çalışmada da Berlin Devlet Kütüphanesi (Staatsbibliothek zu Berlin) Ms. or. oct. 3652 numarada kayıtlı bir nazire mecmuasında yer alan, Beyâzî mahlasıyla yazılmış 39 adet gazelin klasik Türk edebiyatı sahasına tanıtılması amaçlanmaktadır. Çalışmanın giriş bölümünde şiir mecmualarına ve söz konusu mecmuaya dair genel bilgiler verilmiştir. Birinci bölümde Beyâzî mahlasıyla şiirler yazan şairlerin biyografilerine yer verilmiş, ikinci bölümde çalışmaya konu olan gazellerin şekil ve muhtevasına dair öne çıkan özellikler tespit edilip sıralanmış, üçüncü bölümde ise gazeller çeviri yazıya aktarılmıştır. Sonuç bölümünde çalışmaya konu olan gazellerin şekil ve muhtevalarına dair yapılan değerlendirmelerden sonra, gazellerin klasik üslupla yazılmış başarılı örneklerden olduğu belirtilmiştir.
Mechanistic impact of fibrosis by parathyroid hormone excess
Authors: Baradaran Azar
Published: August 2023

Klotho is a protein that has been found to play a role in regulating parathyroid hormone (PTH) levels. The literature suggests an intricate relationship between Klotho and PTH. Klotho acts as a co-receptor for fibroblast growth factor 23 (FGF23), a hormone that helps regulate phosphate and vitamin D metabolism. Klotho deficiency has been associated with increased PTH levels and secondary hyperparathyroidism. Several studies have investigated the relationship between Klotho and PTH levels. Some studies have shown that Klotho levels are inversely correlated with PTH levels, suggesting that higher Klotho levels may lead to lower PTH levels. Other studies have found that Klotho deficiency can contribute to PTH resistance, leading to persistent hyperparathyroidism. Additionally, the Klotho-PTH axis holds promise as a potential target for therapeutic interventions in calcium and phosphate disorders.
Towards a Communicative City: Applying a New Framework for Understanding Communication and City
Authors: Li Longfei , Hai Xiangyu
Published: August 2023

Since the Industrial Revolution, with the productivity change brought by technology and modern mass media, the distance between time and space has been shortened and the imagined "urbancommunity" has been brought about. Newspapers, television and other mass media can not only have information functions, but also unite and connect people into a whole through the communication network, thus promoting the integration of urban communities. However, with the development of the internet and the explosive growth of urban population, the rise of individualism has made the connection of traditional urban society declared unorganized, and the traditional mass media has also lost its unified integration ability (Bruhn, 2011:8). The city has fallen into an unprecedented communication crisis, and the construction of a coordinated and unified relationship between different individuals has become anurgent problem to be solved. In other words, the global expansion of the modernization process has led to the fragmentation of society, and people find themselves in a modern world that has lost contact with the roots of communicability.
Customer Grouping for Customer Relationship Management Optimization with the K-Means Algorithm
Authors: Montero Zidane Dwi
Published: August 2023

Customer Relationship Management (CRM) is a tool that can help organizations/companies to achieve their goals. Models that can be developed in relationships are trust and commitment. Trust can come when both parties share experiences. The rapid development of information and technology has led to significant changes in business competition. Rani 2 Supermarkets are modern shopping centers that provide a variety of household needs at low prices and quality. Rani Supermarkets is located at Jl. Zeinizein Painan Pesisir Selatan District. The Rani 2 Supermarket has implemented strategies to build customer loyalty, such as providing additional discounts, facilitating transactions, giving certain customer cards. The problem is that supermarkets don't know which customers are loyal and haven't based it on a pattern. One method that can be used in analyzing CRM is data mining. Clustering with the K-Means grouping technique will produce customer information based on clusters. This cluster is divided into two, namely productive customer clusters and less productive customer clusters. The problem to be solved with this method is how knowledge is useful for the company, namely increasing customer loyalty. Through the K-Means Cluster Technique, this will be used as material for implementing a customer relationship management strategy with the aim of increasing customer loyalty and sales volume
Archive of Lost Mountains
Authors:   University of Kentucky, Sturlaugson Brent
Published: August 2023

The Archive of Lost Mountains is a collection of drawings and models that document the impacts of mountaintop removal coal mining in Appalachia. Specifically, it recreates the peaks destroyed by mining, and assembles data concerning permit holders, raw material extraction, labor hours worked, and other details. By using architectural conventions to represent these landscapes, the archive seeks to establish deeper connections between the practice of architecture and the sites of its material extraction.
Exploring a Sustainable Building’s Impact on Occupant Mental Health and Cognitive Function in a Virtual Environment
Authors:   University of Maryland, Vivino Anthony , Bernat Edward ,   University of Maryland, Simon Madlen ,   University of Maryland, Hu Ming ,   University of Maryland, Fix Spencer ,   University of Maryland
Published: August 2023

The objective of this experimental project is to develop, test, and validate a data-driven neuroscience approach, using virtual environments with electroencephalogram (EEG) and event-related potential (ERP) approaches. The goal is to provide objective neurophysiological information about how people respond to built environments and how sustain¬able buildings (SBs) impact people differently compared to conventional buildings (CBs). The hypotheses are centered on assessing for increased visual engagement with the SBs (views of external natural environment and internal spatial arrangement). The core framework is based on the idea that greater engagement with the built environment will enhance mindfulness (greater focus on the present environment), which will reduce stress and increase engagement with present-focused tasks. We employed both conventional time-domain and more advanced time-frequency analyses to assess brain activity while participants engaged in the environments.
White Space: the Architecture of Institutional Racism
Authors:   University of Miami, Barnes Germane , Reynolds John ,   Miami University, Roudbari Shawhin ,   University of Colorado Boulder, Niles Skye ,   University of Colorado Boulder
Published: August 2023

Racist ideologies are embedded in spaces we design. From courtrooms to classrooms, and from circulation to threshold, architects in the US design spaces that reflect an institutionalization of white supremacy. While the whiteness of such spaces may be invisible to some, it is oppressive and even violent for others. This paper contributes a framework for describing and analyzing institutional white space in architecture. We build on sociological theories of white institutions to demonstrate how architectural elements express and perpetuate institutional racism. We illustrate this framework through reviewing sociological interpretations of institutional spaces. Such elements as spatial hierarchy in courtrooms not only harbor a white institutional history, but they engender a racialized experience of space. We argue that reading architecture through the proposed lens of white institutional space is an important step toward confronting institutional racism inherent in design and space.
Improvised Making: New Analytical Practices Towards an Uncertain Future
Authors:   University of Waterloo, Frayne Nicholas
Published: August 2023

The impacts of spatial experience on social dynamics are complex. They happen through the totality of experience, which we cannot always name, describe, or explain. In light of the urgent challenges of social justice, systemic exploitation, and unsustainable practices that are characterizing this century, we need to reassess how we analyze architecture’s relationship with societal change. This article argues that new analytical practices must include exploratory, improvisational expressions that can help our understandings of architecture include a more expansive definition of experience. Such creative expressions make the bodily, unnameable aspects of experience sensible, thereby able to be incorporated into our broader analyses of architecture’s operation in social life. These improvisational practices are fundamentally uncertain, resisting explanation and the ethical perils of certainty in knowledge-making. Employed in an exami¬nation of the Tuol Sleng Genocide Museum in Cambodia, these practices helped to create an analysis grounded in the textural expressions and incomplete forces that characterize bodily experience. Taking the form of a charcoal drawing, the improvised expression entered into the analytical process as a framing mediator for the analyst’s response to their encounter with the architecture. By grounding analysis in bodily experience, we are able to expand our ‘analytical toolbox’ and can come to unexpected conclusions about how architecture shapes the way we understand the world. Proposing that an analysis of an architectural project should take shape between improvisational making and thinking, this paper positions architectural analysis as an agent of change; in expanding our practices for understanding architecture, we can better design spaces that support a more connective, open, and just future.
Cloud as an Alternative Architecture
Authors:   Princeton University, Jia Ruo
Published: August 2023

In A Theory of /Cloud/ (1972), the cloud, or rather, the graph of cloud, served as the entry point of the French art historian and theorist Hubert Damisch (1928-2017) in his understanding of the limits of Western art and art history as framed since the Renaissance. Here he initiated another possibility of painting—a “theory” of painting, which he simultaneously termed “a history of painting”—by concluding the book with an examination of Chinese landscape painting. Participating in the sinophelia of French intellectuals that accompanied the Chinese Cultural Revolution launched by Mao, Damisch’s turn represented his philosophical initiative to reflect on and shift away from Western metaphysics, especially from the negative dialectics of Hegel, and towards a different architecture based on a harmonious and positive materialist dialectic inspired by Chinese Taoist and Chan Buddhist philosophy. Here, in Damisch’s “reinvention” of Chinese painting, the cloud not only literally entered paintings to negotiate the intertextuality of mountain and water, ink and brush, and even that of the painter and painting, but also to fill the role of the materialist body in a different perspective of world formation—as the breath, the one movement that sustains or constitutes all life. In Damisch’s vision, such a cloud even leads to a different kind of architecture, one that counters the philosophical metaphor of architecture as the stability of the arche, the subject, the essence, or any anchored center. The cloud and its philosophical architectural alternative also contribute to a reflection on the very physicality of architecture, leading to the formation of an architecture in absentia, to which Damisch was to return in 2003 when discussing Diller+Scofidio’s Blur Building (2002), as well as the Chinese architecture of the Ming Dynasty.
The Problematic Nature Between Architectural Pleasure and Well-Being
Authors:   University of Idaho, Mead Phillip G.
Published: August 2023

This paper focuses on the problematic relationship between architectural pleasure and well-being or happiness. It attempts to update the ancient philosophical debate on the conflict between the pleasures promoted by hedonism, and the pleasures and virtues of well-being promoted by eudemonia in terms of architectural design through the lens of today’s positive psychology movement. This emerg¬ing field has identified, to a limited extent, when pleasure and well-being can conflict resulting in addiction, while at other times pleasure serves as a pump to the higher echelons of well-being, or what Aristotle calls eudaimonia. This paper attempts to identify the same for architecture. Since Vitruvius, architects have written on our preferences which appear to bring pleasure – some with empirical evidence. By taking stock of architectural writings and program elements that aim to deliver pleasure, this paper asks which of these resonate with philosophical and positive psychology findings on higher pleasures. Particularly relevant are the findings of psychologist Barbra Fredrickson’s broaden and build theory of positive emotions which sheds light on how design delight may lead to positive psychology’s promotion of higher forms of well-being such as: engagement, relationships or sense of community, meaning and achievement. The programming and design of Helsinki’s new central library by ALA Architects illustrates virtuous pleasures that serve a higher purpose in a country and city that ranks first in Gallup’s 2019 and 2020 World Happiness Reports.
Arene ruthenium assemblies to treat hypoxic tumors
Authors:   , Gaschard Marie
Published: August 2023

The actual therapies for fighting cancers are not always efficient and are commonly followed by side effects, since the solutions are not enough selective. Photodynamic therapy (PDT) is an appealing treatment to tackle the issue of selectivity. In fact, to work and to be efficient, PDT needs to combine in the same physico-temporal space three elements: a light, a drug (also called photosensitizer) and oxygen. Nevertheless, the lack of oxygen is one of the main characteristics in a majority of cancers. This phenomenon is called hypoxia. The efficiency of a treatment which needs oxygen will consequently be reduced. So, there is a real need to find a solution to bypass hypoxia. One of the possible answers is the synthesis of new structures able to transport oxygen into tumorous cells. Our attention was focused on arene ruthenium complexes with subunits that can capture oxygen. These probes are derivatives of anthracene or dimethyldihydropyrene cores. Then, this work consisted, not only in the synthesis and in the characterization of these molecules, but also in their studies in solution and in vitro, to determine their ability to transfer oxygen to cells, and ultimately to cancer cells.
CLASSICAL FINDINGS OF CHORIORETINAL COLOBOMA - CASE SERIES
Authors: B Ramya. , R Ravikumar. , Prasanthi Prasanthi , Premsai Premsai
Published: August 2023

Coloboma can develop as a result of abnormal fetal ssure closure in the fth to sixth week of pregnancy. Coloboma is extremely uncommon,
occurring in only 0.7 per 10,000 live births . We would like to present to you two such cases with varying age group .
LINEZOLID INDUCED OPTIC NEURITIS AND ITS MANAGEMENT: A CASE SERIES OF FOUR PATIENTS
Authors: Prakash Pawnarkar Monisha , Meshram Priti , Pujari Vishwanath , Hegde Rohit
Published: August 2023

Optic neuropathy has been reported as a side effect of long-term use of linezolid. This is particularly seen in cases of multi or extensively drug
resistant tuberculosis where treatment with linezolid may continue for about 18-20 months. Here we reported four cases of MDR-PTB treated
patients with a regimen containing linezolid who developed progressive painless loss of vision during the course of treatment. In all the four cases,
the visual symptoms resolved completely on withdrawing linezolid. In our cases we treated optic neuropathy with steroids. Early recognition of
this rare side effect and timely withdrawal may salvage the eyesight of such patients.
SARCOMA HISTIOCÍTICO EM CÃES: RELATO DE DOIS CASOS .
Authors: Silva Fernanda Barros , Freire Luísa Guedes , De Castro Ana Clara , Zenteno Igor Matheus Amaral Gauna , Rodrigues Thaís , Fabretti Andrei Kelliton
Published: August 2023

O sarcoma histiocítico (SH) é um grupo de neoplasias malignas raras, originárias de células dendríticas que, por esse motivo, pode se desenvolver em quase todos os tecidos de forma localizada ou disseminada. Os sinais clínicos variam de acordo com os órgãos acometidos, sendo geralmente inespecíficos. Além de apresentar evolução feroz e agressiva, é pouco responsivo a tratamentos quimioterápicos, sendo considerada fatal após o envolvimento linfonadal. Esse trabalho teve como objetivo relatar dois casos de sarcoma histiocítico disseminado em cães atendidos em um Hospital Veterinário Escola do Mato Grosso do Sul. O primeiro animal, uma fêmea, labrador, de três anos, apresentava distensão abdominal pronunciada e emagrecimento progressivo, além de caquexia, dispneia e linfadenomegalia periférica. Exames hematológicos e citológicos foram realizados e evidenciaram alterações como linfopenia, toxicidade de neutrófilos e hiperalbuminemia. O exame radiográfico apresentou alterações compatíveis com metástase. A cadela veio a óbito 20 dias após a consulta inicial e foi encaminhada para necropsia, que determinou o diagnóstico de SH por meio da observação das células neoplásicas características em fígado, pulmão e córtex renal. O cadáver da segunda paciente, uma fêmea sem raça definida, foi encaminhada para o setor de anatomia patológica com histórico de aumento de volume abdominal, anorexia, emagrecimento e dispneia. A necropsia revelou envolvimento de baço, fígado, linfonodos mediastínico e hepático, intestino, mesentério, estômago, bexiga e rins pelo SH. Por seu caráter agressivo e sinais abrangentes, esse tipo de neoplasma deve ser considerado como diagnóstico diferencial a fim de estabelecer tratamento paliativo que aumente o tempo de sobrevida do paciente.
Investigation of thermalphysics
of metal cutting with coated cutting tools
Authors: Migranov A.M. , Migranov M.Sh. , Shehtman S.R.
Published: August 2023

The results of computer simulation of thermophysical phenomena in the contact zone during blade cutting of metals
with multi-layer composite wear-resistant coatings that ensure the adaptability of the cutting wedge to friction conditions
are presented. On-site experimental studies of the cutting temperature during turning with various coatings, structuralphase
analysis of the surface layer of the cutting tool to explain the mechanism of formation of secondary structures with
a shielding effect self-organization.
Study of the wear intensity of the cutting tool
with adaptable coatings
Authors: Migranov M.Sh. , Migranov A.M.
Published: August 2023

The improvement of cutting tools through the use of tool materials and wear-resistant coatings, which, taking into
account the cutting conditions, allow to increase the wear resistance of the tool due to the formation of secondary structures
during friction in the cutting zone is considered. On the basis of thermodynamics of nonequilibrium processes the
model has bееn developed, allowing to predict wear resistance and others tribotechnical parametres hardloaded hightemperature
interfaces.
Implementation of Wadi'ah Academic In Sharia Banking
Authors: Choiriyah Choiriyah , Noviani Dwi , Richway Richway
Published: August 2023

Public interest in muamalah according to shari'ah is a growing factor in the Indonesian economy. To develop society, the principle of Islamic Banking Institutions or Syari'ah Banking is to dismantle the interest system and replace it with a system for measuring the results of savings and loan operations. The most common form of fundraising contract in Islamic banks is the savings contract, which is also known as the wadi'ah contract. This study uses a constructive paradigm with a qualitative descriptive analysis for this type of research conducted on the literature. To process data, users use two types: secondary data and primary data. Data collection techniques are carried out using documentation studies. Data analysis uses content analysis with a more thorough process which includes categorization and selection in an in-depth format. In the process of collecting and analyzing data, researchers used two models of triangulation of sources. According to evidence, Wadi'ah helps those in need. Based on its application in Islamic banking, the term "wadi'ah contract" is divided into two categories, namely "Safe Keeping" and "Safe Deposit Box". "Safe Keeping" refers to the safekeeping of documents, contracts and other important documents, while "Safe Deposit Box" refers to the safekeeping of important papers, contracts and other documents. Every sharia banking organization must carry out its banking activities in accordance with Islamic sharia principles, especially those related to credit procedures. Islamic banking not only has a destination, but also has various problems. Including sharia products and tabling based on wadi'ah contracts.
Analysis of The Influence of Profit Sharing, Ijarah And NPF Financing On The Profitability of Sharia Business Units In Indonesia
Authors: Wijanarko Fauzuna Naufal , Susanti Rini Dwi , Rizki Darlin
Published: August 2023

Indonesian statistical data shows significant developments in the Islamic banking sector. This is evidenced by the increase in the number of 20 Islamic Commercial Banks (BUS) with an average asset of 478,831 billion and 13 Islamic Business Units (UUS) with an average asset of 255,943 billion. The purpose of this study was to determine the effect of profit sharing, ijarah funding and NPF on profitability (ROA) in Indonesian Islamic Business (UUS). Profit sharing and ijarah financing is a form of bank business to generate profits in accordance with sharia principles. NPF is bad credit that arises when bank funds are channeled, but can affect bank income. The data source for this research is secondary data in the form of UUS (Maybank Indonesia) financial reports for the 2017-2022 period using a quarterly model. The research method used is a quantitative approach using linear regression analysis techniques. The results of this study indicate that simultaneously profit-sharing financing, ijarah and NPF have a positive effect on ROA. Partial test results, profit sharing and ijarah financing have a significant effect on ROA, while NPF has no significant effect on ROA.
Integrating Exempt Values Inside The Family To Prevent Fraud
Authors: Ubaidillah Muhammad , Umma I’ana , Sholih Muhammad Wildan
Published: August 2023

Fraud is a serious problem in the business world. Fraud includes three main things, namely assets misappropriation, faudulent statement and corruption. Various efforts have been made in the framework of prevention. However, fraud still exists today. On the other hand, the family has the potential and an important role in shaping one's character. There are various positive values that can be instilled in children in family institutions. The problem is, many families are now just a mere formality. In fact, parents can educate their children to become anti-fraud individuals, one of which is by setting an example for their children. Therefore, this article proposes a new concept that combines the previous concepts. The concept is to instill exemplary values in the family to prevent fraud. This study uses descriptive analysis to propose the concept of cultivating exemplary values in the family to prevent fraud. This study uses a library research approach to collect secondary data from journal articles, books, reports, and websites that contain the existing concepts of exemplary values and fraud prevention. It is hoped that this formulation can actually reduce fraud that occurs later.
Pengaruh Dukungan Selebriti dan Ulasan Pelanggan Terhadap Niat Beli Konsumen pada Marketplace Tokopedia di Bandar Lampung
Authors: Assegaf Syifa Hera , Fihartini Yuniarti , Ramelan Mudji Rachmat
Published: August 2023

Tujuan dari penelitian ini yaitu untuk menguji pengaruh yang diberikan oleh variabel dukungan selebriti dan ulasan pelanggan terhadap niat beli konsumen pada Marketplace Tokopedia di Bandar Lampung. Adapun data yang digunakan dalam penelitian ini yaitu data primer yang diperoleh dari hasil jawaban responden yang dikumpulkan dengan bantuan kuesioner, dan data sekunder yang diperoleh dari literatur, jurnal maupun artikel. Jumlah sampel dalam penelitian ini adalah sebanyak 120 responden. Metode pengambilan sampel menggunakan purposive sampling yaitu teknik untuk menentukan sampel dengan kriteria sesuai yang ditentukan peneliti. Metode analisis yang digunakan dalam penelitian ini adalah uji validitas, uji reliabilitas, uji parsial (uji-t), dan koefesien determinasi (R2). Sedangkan tahap analisa menggunakan analisis regresi linier berganda dengan bantuan aplikasi SPSS 26. Hasil penelitian ini menunjukan bahwa dukungan selebriti dan ulasan pelanggan berpengaruh signifikan terhadap niat beli konsumen.
CAMELLIA IN CHINESE CULTURE
Authors:   Laboratory of Landscape Architecture and Ethnobotanical Research, Nikitsky Botanical Garden — National Scientific Center of the Russian Academy of Sciences, Moscow representative Office, Kotova A.V.
Published: August 2023

In the centuries-old history of China, plants have played an important role. They served as a source of food, were used as medicines to treat ailments, and were objects of worship. In the process of development of Chinese society, the use of plants has become more versatile. One of such significant plants is Camellia, and in particular, Chinese camellia (Camellia sinensis (L) Kuntze), known worldwide as tea. In addition to useful properties, it has high decorative qualities. The diversity with which the camellia flower was endowed allowed it to become a favorite theme for artists and poets of all periods.
THE MEANING AND SYMBOLISM OF ORCHIDS IN CHINESE CULTURE
Authors:   Laboratory of Landscape Architecture and Ethnobotanical Research, Nikitsky Botanical Garden — National Scientific Center of the Russian Academy of Sciences, Moscow representative Office, Khomutovskiy M.I. ,   Lomonosov Moscow State University
Published: August 2023

The article provides data on the symbolic significance of the orchid in the culture of China, where it was given a special place. She has become a source of inspiration for many masters in the field of painting, calligraphy, and music. Thanks to Confucius, the orchid began to symbolize the nobility and steadfastness of a person's character. It was in China that the first methods of orchid cultivation were developed, which have been perfected for several centuries.