bluuebunny/crossref_metadata_2025 huggingface dataset:
Reported hepatotoxicity and hepatotoxicity guidance in the product information of protein kinase inhibitors in oncology registered at the European Medicines Agency
Authors: Maliepaard Marc , Faber Yoran S. , van Bussel Mark T. J.
Published: February 2023

Protein kinase inhibitors (PKIs) used in oncology can induce severe and even fatal hepatotoxicity. Several PKIs are registered within a certain class to target a specific kinase. No systematic comparison of the reported hepatotoxicity and clinical guidance for monitoring and management of hepatotoxic events between the various PKI summaries of product characteristics (SmPC) is yet available. A systematic analysis of data on 21 hepatotoxicity parameters obtained from the SmPCs and European public assessment reports (EPARs) of European Medicines Agency‐approved antineoplastic PKIs (n = 55) has been conducted. The median reported incidence (range) of all grades of aspartate aminotransferase (AST) elevations was 16.9% (2.0%–86.4%) for PKI monotherapy, with 2.1% (0.0%–10.3%) being grade 3/4 and for all grades alanine aminotransferase (ALT) elevations 17.6% (2.0%–85.5%), with 3.0% (0.0%–25.0%) being grade 3/4. Fatalities due to hepatotoxicity were reported for 22 out of 47 PKIs (monotherapy) and for 5 out of 8 PKIs (combination therapy). A maximum grade of grade 4 and grade 3 hepatotoxicity was reported for 45% (n = 25) and 6% (n = 3), respectively. Liver parameter monitoring recommendations were present in 47 of the 55 SmPCs. Dose reductions were recommended for 18 PKIs. Discontinuation was recommended for patients meeting Hy's law criteria (16 out of 55 SmPCs). Severe hepatotoxic events are reported in approximately 50% of the analyzed SmPCs and EPARs. Differences in the degree of hepatotoxicity are apparent. Although liver parameter monitoring recommendations are present in the vast majority of the analyzed PKI SmPCs, the clinical guidance for hepatotoxicity was not standardized.
Regulation of Interfacial Lattice Oxygen Activity by Full‐Surface Modification Engineering towards Long Cycling Stability for Co‐Free Li‐Rich Mn‐Based Cathode
Authors: Guo Weibin , Zhang Yinggan , Lin Liang , Liu Yuanyuan , Fan Mengjian , Gao Guiyang , Wang Shihao , Sa Baisheng , Lin Jie , Luo Qing , Qu Baihua , Wang Laisen , Shi Ji , Xie Qingshui , Peng Dong‐Liang
Published: February 2023

The construction of a protective layer for stabilizing anion redox reaction is the key to obtaining long cycling stability for Li‐rich Mn‐based cathode materials. However, the protection of the exposed surface/interface of the primary particles inside the secondary particles is usually ignored and difficult, let alone the investigation of the impact of the surface engineering of the internal primary particles on the cycling stability. In this work, an efficient method to regulate cycling stability is proposed by simply adjusting the distribution state of the boron nickel complexes coating layer. Theoretical calculation and experimental results display that the full‐surface boron nickel complexes coating layer can not only passivate the activity of interface oxygen and improve its stability but also play the role of sharing voltage and protective layer to gradually activate the oxygen redox reaction during cycling. As a result, the elaborately designed cobalt‐free Li‐rich Mn‐based cathode displays the highest discharge‐specific capacity retentions of 91.1% after 400 cycles at 1 C and 94.3% even after 800 cycles at 5 C. In particular, the regulation strategy has well universality and is suitable for other high‐capacity Li‐rich cathode materials.
A maturity model for the autonomy of manufacturing systems
Authors: Mo Fan , Monetti Fabio Marco , Torayev Agajan , Rehman Hamood Ur , Mulet Alberola Jose A. , Rea Minango Nathaly , Nguyen Hien Ngoc , Maffei Antonio , Chaplin Jack C.
Published: February 2023

Modern manufacturing has to cope with dynamic and changing circumstances. Market fluctuations, the effects caused by unpredictable material shortages, highly variable product demand, and worker availability all require system robustness, flexibility, and resilience. To adapt to these new requirements, manufacturers should consider investigating, investing in, and implementing system autonomy. Autonomy is being adopted in multiple industrial contexts, but divergences arise when formalizing the concept of autonomous systems. To develop an implementation of autonomous manufacturing systems, it is essential to specify what autonomy means, how autonomous manufacturing systems are different from other autonomous systems, and how autonomous manufacturing systems are identified and achieved through the main features and enabling technologies. With a comprehensive literature review, this paper provides a definition of autonomy in the manufacturing context, infers the features of autonomy from different engineering domains, and presents a five-level model of autonomy — associated with maturity levels for the features — to ensure the complete identification and evaluation of autonomous manufacturing systems. The paper also presents the evaluation of a real autonomous system that serves as a use-case and a validation of the model.
The role of European municipalities and regions in financing energy upgrades in buildings
Authors: Economidou Marina , Della Valle Nives , Melica Giulia , Bertoldi Paolo
Published: February 2023

Energy efficiency in buildings has a central role to play in reaching the climate neutrality goal set by the European Green Deal. With detailed knowledge of their building stock and the profile of their occupants, regional and local authorities can forge an important link between financiers, industry professionals and homeowners to ensure the successful deployment of financial schemes that support the uptake of energy efficiency upgrades. This paper provides a first assessment of the role of regional and local authorities by reviewing relevant initiatives and programmes on energy efficiency. Based on a questionnaire completed for more than 150 schemes, it explores how European municipalities and regions stimulate energy upgrades in residential, commercial and public buildings through public financial support. It is found that 60% of the examined schemes are offered in the form of grants and subsidies, and 45% of them targeted residential upgrades. The use of EU cohesion policy funds in supporting regional schemes, and promotion of energy efficiency investments at local level through the European Covenant of Mayors initiative are also explored. In spite of possible resource limitations at this level of governance, regional and local authorities are in a good position to utilise European structural or research funds to develop financial schemes, as standalone programmes or blended with national ones, thus providing additional support and funds for deep renovations. The results suggest that energy efficiency in buildings has become an important part of local and regional strategies in several European countries, but could be further enhanced.
cleAR: an interoperable architecture for multi-user AR-based school curricula
Authors: Masneri Stefano , Domínguez Ana , Sanz Miguel , Zorrilla Mikel , Larrañaga Mikel , Arruarte Ana
Published: February 2023

Although there are some experiences that demonstrate the validity of the use of augmented reality in schools to help students understand and retain complex concepts, augmented reality has not been widely adopted in the education sector yet. This is in part because it is hard to use augmented reality applications in collaborative learning scenarios and to integrate them in the existing school curricula. In this work, we present an interoperable architecture that simplifies the creation of augmented reality applications, enables multi-user student collaboration and provides advanced mechanisms for data analysis and visualization. A review of the literature together with a survey answered by 47 primary and secondary school teachers allowed us to identify the design objectives of cleAR, an architecture for augmented reality-based collaborative educational applications. cleAR has been validated through the development of three proofs of concept. cleAR provides a more mature technological ecosystem that will foster the emergence of augmented reality applications for education and their inclusion in existing school programs.
Disentangling causality: assumptions in causal discovery and inference
Authors: Vonk Maarten C. , Malekovic Ninoslav , Bäck Thomas , Kononova Anna V.
Published: February 2023

Causality has been a burgeoning field of research leading to the point where the literature abounds with different components addressing distinct parts of causality. For researchers, it has been increasingly difficult to discern the assumptions they have to abide by in order to glean sound conclusions from causal concepts or methods. This paper aims to disambiguate the different causal concepts that have emerged in causal inference and causal discovery from observational data by attributing them to different levels of Pearl’s Causal Hierarchy. We will provide the reader with a comprehensive arrangement of assumptions necessary to engage in causal reasoning at the desired level of the hierarchy. Therefore, the assumptions underlying each of these causal concepts will be emphasized and their concomitant graphical components will be examined. We show which assumptions are necessary to bridge the gaps between causal discovery, causal identification and causal inference from a parametric and a non-parametric perspective. Finally, this paper points to further research areas related to the strong assumptions that researchers have glibly adopted to take part in causal discovery, causal identification and causal inference.
Knowledge discovery assistants for crash simulations with graph algorithms and energy absorption features
Authors: Pakiman Anahita , Garcke Jochen , Schumacher Axel
Published: February 2023

We propose the representation of data from finite element car crash simulations in a graph database to empower analysis approaches. The industrial perspective of this work is to narrow the gap between the uptake of modern machine learning methods and the current computer-aided engineering-based vehicle development workflow. The main goals for the graph representation are to achieve searchability and to enable pattern and trend investigations in the product development history. In this context, we introduce features for car crash simulations to enrich the graph and to provide a summary overview of the development stages. These features are based on the energy output of the finite element solver and, for example, enable filtering of the input data by identifying essential components of the vehicle. Additionally, based on these features, we propose fingerprints for simulation studies that assist in summarizing the exploration of the design space and facilitate cross-platform as well as load-case comparisons. Furthermore, we combine the graph representation with energy features and use a weighted heterogeneous graph visualization to identify outliers and cluster simulations according to their similarities. We present results on data from the real-life development stages of an automotive company.
Retrospective and Prospective Analysis on “Sexting”: Indicators of Productivity, Dispersion, and Content (2009–2019)
Authors: Rodríguez-García Antonio Manuel , Moreno-Guerrero Antonio José , García-Carmona Marina
Published: February 2023

In the last decade, research on “sexting” has undergone an exponential increase, giving rise to the publication of numerous studies clarifying its meaning, offering information of educational value, and favoring a good use of technology to prevent problems caused by this exchange of sexual information. The aim of this article was to analyze the production, performance, impact, and content of scientific articles evaluating the “sexting” thesaurus (title, abstract, and/or keywords) between 2009 and September 2019. Articles were sourced from two internationally recognized databases: Scopus and Web of Science. A scientometric study was then carried out on a sample of 641 articles that met the established inclusion criteria. The main findings indicate that “sexting” is a very recent research focus, but one in full growth phase, with scientific production related to the topic likely to double over the next few years. Although “sexting” has been researched worldwide, the scientific production of the US and American authors is the most notable. There were also some differences between the Scopus and Web of Science databases, mainly in the volume of production and the trend. However, the studies do show a common research line, “cyberbullying,” and a common target population: adolescents. Therefore, the content analysis reveals that research on “sexting” is mostly carried out with adolescents and takes into consideration other themes such as cyberbullying, dating violence, and sexuality.
Systematic Review of Gender-Specific Child and Adolescent Mental Health Care
Authors: Herrmann Lena , Reiss Franziska , Becker-Hebly Inga , Baldus Christiane , Gilbert Martha , Stadler Gertraud , Kaman Anne , Graumann Lina , Ravens-Sieberer Ulrike
Published: February 2023

Gender differences in mental health emerge as early as in childhood and adolescence, highlighting the potential need for gender-specific child and adolescent mental health care. However, it is unclear how gender-specific child and adolescent mental health care is implemented and whether its’ approaches are useful. Therefore, this study reviews gender-specific interventions and their effectiveness for child and adolescent mental health. Five databases were searched for articles published between 2000 and 2021. In total, 43 studies were included. Most interventions were conducted in school (n = 15) or community settings (n = 8). Substance-related disorders (n = 13) and eating disorders (n = 12) were addressed most frequently. Most interventions targeted girls (n = 31). Various gender-specific aspects were considered, including gender-specific risk and protective factors (n = 35) and needs (n = 35). Although most interventions yielded significant improvements in mental health outcomes (n = 32), only few studies reported medium or large effect sizes (n = 13). Additionally, there was a lack of strong causal evidence derived from randomized controlled trials, calling for more rigorous trials in the research field. Nevertheless, our findings indicate that gender-specific mental health care can be a promising approach to meet gender-specific mental health needs.
Temporal repeatability of behaviour in a lizard: implications for behavioural syndrome studies
Authors: Polverino Giovanni , Buchholz Kali M. , Goulet Celine T. , Michelangeli Marcus , Chapple David G.
Published: February 2023

It is well established that, across taxa, individuals within populations exhibit consistent differences in their behaviour across time and/or contexts. Further, the functional coupling of traits may result in the formation of a behavioural syndrome. Despite extensive evidence on the existence of consistent among-individual differences in behaviour and behavioural syndromes in the animal realm, these findings are predominately based upon short-term assessments, leading to questions regarding their stability over longer periods. Understanding if these estimates are temporally stable would allow predictions of individual behaviour to be made using short-term repeated measures. Here, we used 57 adult male delicate skinks (Lampropholis delicata) to evaluate the stability of behavioural variation observed both among (animal personality and behavioural plasticity) and within individuals (behavioural predictability), as well as behavioural syndromes, across short (four weeks) and long (five months) timeframes. To do so, we repeatedly assayed activity, exploration, and boldness five times per each individual. Overall, our study revealed complex patterns of behavioural variation and trait (co)variation over time. Activity was always repeatable across time intervals, whereas behavioural differences among individuals in exploration and boldness were not consistent. Yet a behavioural syndrome between activity and exploration was detected at both shorter and longer temporal scales, suggesting that syndrome structure in these traits does not vary as a function of time. Our findings indicate that, at least for some traits (e.g. activity) and studies, short-term measures may be adequate in serving as a proxy for long-term variation in individual behaviour, and to reveal the existence of behavioural syndromes at the population level.
Predation governs the eulittoral distribution of a ubiquitous Mediterranean gastropod
Authors: Wright Luka Seamus
Published: February 2023

Topshell gastropods are among the most important intertidal biofilm grazers. Present throughout the Mediterranean, this sea’s only exclusively eulittoral trochid, Phorcus turbinatus, is spatially separated from its infralittoral congeners, P. articulatus, P. richardi and P. mutabilis. Despite its ubiquity, data on its fundamental ecology are lacking. By a series of laboratory and field experiments, I show that predation fixes the lower boundary of the vertical range inhabited by P. turbinatus precisely at lowest astronomical tide (LAT). Predicted in situ predation risk rapidly increases from 30% d–1 at the mean position of P. turbinatus (+0.31 m) to 84% d–1 at 1 m below LAT. At least nine predators across all major phyla prey on P. turbinatus. Important in terms of abundance, zonation and frequency of predation events are the two muricids Stramonita haemastoma (+0.08 m) and Hexaplex trunculus (−1.73 m) on exposed and sheltered coasts, respectively, along with Thalassoma pavo (−0.56 m) and Hermodice carunculata (−1.24 m). Physiological constraints seem to be of secondary importance since P. turbinatus survives up to 1 week fully immersed in situ. Therefore, predation risk likely is the ultimate driver of vertical distribution and thus physiological adaptation of littoral Mediterranean trochids.
The relevance of title, abstract, and keywords for scientific paper quality and potential impact
Authors: Chamorro-Padial Jorge , Rodríguez-Sánchez Rosa
Published: February 2023

Authors, editors, and reviewers need to have a good perception regarding the quality of a manuscript in order to improve their skills, save effort, and prevent errors that can affect the submission procedure. In this paper, we compared the author’s perception of a manuscript’s quality with the manuscript’s actual impact. In addition, we analyzed the uncertainty of the author’s perception of the manuscript’s quality. From there, we defined ‘partition’ as the author’s ability to perceive the actual quality. We did this by launching a website for the use of the scientific community. This webpage provided a tool to help improve an investigator’s skill in understanding and recognizing the quality of a manuscript so as to help researchers improve and maximize their works’ potential impact. We carried out the experiment with 106 experienced users who tested our webpage. We found that the Abstract, the Title, and the Keywords were enough to perform a substantially decent evaluation of a manuscript. Most of the researchers were able to determine the quality of a paper in less than a minute from this small amount of information.
Coactivation of Autonomic and Central Nervous Systems During Processing of Socially Relevant Information in Autism Spectrum Disorder: A Systematic Review
Authors: Karjalainen Suvi , Aro Tuija , Parviainen Tiina
Published: February 2023

Body-brain interaction provides a novel approach to understand neurodevelopmental conditions such as autism spectrum disorder (ASD). In this systematic review, we analyse the empirical evidence regarding coexisting differences in autonomic (ANS) and central nervous system (CNS) responses to social stimuli between individuals with ASD and typically developing individuals. Moreover, we review evidence of deviations in body-brain interaction during processing of socially relevant information in ASD. We conducted systematic literature searches in PubMed, Medline, PsychInfo, PsychArticles, and Cinahl databases (until 12.1.2022). Studies were included if individuals with ASD were compared with typically developing individuals, study design included processing of social information, and ANS and CNS activity were measured simultaneously. Out of 1892 studies identified based on the titles and abstracts, only six fulfilled the eligibility criteria to be included in synthesis. The quality of these studies was assessed using a quality assessment checklist. The results indicated that individuals with ASD demonstrate atypicalities in ANS and CNS signalling which, however, are context dependent. There were also indications for altered contribution of ANS-CNS interaction in processing of social information in ASD. However, the findings must be considered in the context of several limitations, such as small sample sizes and high variability in (neuro)physiological measures. Indeed, the methodological choices varied considerably, calling for a need for unified guidelines to improve the interpretability of results. We summarize the current experimentally supported understanding of the role of socially relevant body-brain interaction in ASD. Furthermore, we propose developments for future studies to improve incremental knowledge building across studies of ANS-CNS interaction involving individuals with ASD.
Dams or ponds classification based on a new criterion to assess potential flood damage to roads in case of failure
Authors: Martínez-Gomariz Eduardo , Barbero Carlos , Sanchez-Juny Martí , Forero-Ortiz Edwar , Sanz-Ramos Marcos
Published: February 2023

Dams are hydraulic infrastructure that have several purposes, such as irrigation, hydropower, water supply, flood control, recreation, fish breeding and navigation. However, their failure or malfunctioning can pose a threat to downstream communities, and thus, their safety is paramount to public protection and economic security. A variety of approaches to classify dams can be found in countries worldwide. Their classification allows to distinguish among those that are to be subject to safety regulation in each country. A common approach to classify them is according to their potential damage in case of failure. Roads are usually among the infrastructures that these approaches consider to be assessed in terms of the level of damage that can suffer. A new people-centred criterion is proposed in this paper to assess potential intangible damage (i.e. human lives) when roadways could be flooded due to a dam failure. This novel methodology is based on the Average Daily Traffic (ADT) of roadways and sets a maximum and a minimum number of vehicles expected in the area receiving the flood. To evaluate its appropriateness, it is verified from the results obtained after being applied to three existing ponds located in Catalonia (Spain).
Modeling and analysis of a piezoelectric transducer embedded in a nonlinear damped dynamical system
Authors: Abohamer M. K. , Awrejcewicz J. , Amer T. S.
Published: February 2023

This paper focuses on the dynamical analysis of the motion of a new three-degree-of-freedom (DOF) system consisting of two segments that are attached together. External harmonic forces energize this system. The equations of motion (EOM) are derived utilizing Lagrangian equations, and the approximate solutions up to the third order are investigated using the methodology of multiple scales. A comparison between these solutions and numerical ones is constructed to confirm the validity of the analytic solutions. The modulation equations (ME) are acquired from the investigation of the resonance cases and the solvability conditions. The bifurcation diagrams and spectrums of Lyapunov exponent are presented to reveal the different types of the system’s motion and to represent Poincaré maps. The piezoelectric transducer is connected to the dynamical system to convert the vibrational motion into electricity; it is one of the energy harvesting devices which have various applications in our practical life like environmental and structural monitoring, medical remote sensing, military applications, and aerospace. The influences of excitation amplitude, natural frequency, coupling coefficient, damping coefficient, capacitance, and load resistance on the output voltage and power are performed graphically. The steady-state solutions and stability analysis are discussed through the resonance curves.
Should I stay or should I go: A dynamical model of musicians’ agglomeration and migration
Authors: Alfarone Irene , Merlone Ugo
Published: February 2023

The musicians’ working scenario is characterized by unstable employment, professional oversupply, and competition. To cope with uncertainty musicians frequently migrate to artistic cities for more working and learning opportunities. We introduce dynamical aspects in a well-known model of artistic goods’ production, to shed light on artists’ career choices. The model shows that leaving the city the musicians are in is always a possible choice and when artists decide to migrate their behavior may follow cycles. Finally, the model suggests that the musicians’ working scenario is complex and mutable; therefore, to properly interpret the results, several aspects are to be considered.
Multifaceted diversity changes reveal community assembly mechanisms during early stages of post-logging forest succession
Authors: Lanta Vojtěch , Mudrák Ondřej , Dvorský Miroslav , Bartoš Michael , Šebek Pavel , Čížek Lukáš , Doležal Jiří
Published: February 2023

Plant succession is a fundamental process of vegetation recovery on disturbed sites. Elucidating its mechanisms remains a challenge as succession is influenced by stochastic and deterministic processes related to abiotic and biotic filters. Here, we use a multifaceted diversity approach to reveal mechanisms of successional changes in European oak-hornbeam forests during the first 10 years after selective logging. As the mechanisms controlling succession may depend upon initial abiotic conditions and colonization potential of the surrounding vegetation, we compare changes in taxonomic, functional, and phylogenetic diversity between clearings connected with open habitats and those isolated inside forests. Despite fewer dispersal barriers and higher biomass production in connected clearings, similar mechanisms initially governed succession in post-logging sites. Both clearings had low taxonomic and functional diversity in the first year of succession, as evidenced by significant trait convergence, caused by the legacy of interactions between overstory and understory vegetation in pre-disturbance closed-canopy forests. Colonization by short-lived and light-demanding species in the second and third years after logging has markedly increased the overall taxonomic and functional diversity, as evidenced by significant trait divergence. Connected clearings had higher functional but lower taxonomic and phylogenetic diversity than isolated clearings from the fourth to ten years of succession, probably due to intense competition in more productive habitats. All diversity facets markedly decreased in the last years due to increasing asymmetric competition from regenerating trees. The successional processes were largely deterministic, driven by species’ life-history strategies and biotic interactions (competition) rather than abiotic constraints and stochastic events.
Deep learning image reconstruction algorithm: impact on image quality in coronary computed tomography angiography
Authors: De Santis Domenico , Polidori Tiziano , Tremamunno Giuseppe , Rucci Carlotta , Piccinni Giulia , Zerunian Marta , Pugliese Luca , Del Gaudio Antonella , Guido Gisella , Barbato Luca , Laghi Andrea , Caruso Damiano
Published: February 2023

Purpose

To perform a comprehensive intraindividual objective and subjective image quality evaluation of coronary CT angiography (CCTA) reconstructed with deep learning image reconstruction (DLIR) and to assess correlation with routinely applied hybrid iterative reconstruction algorithm (ASiR-V).

Material and methods

Fifty-one patients (29 males) undergoing clinically indicated CCTA from April to December 2021 were prospectively enrolled. Fourteen datasets were reconstructed for each patient: three DLIR strength levels (DLIR_L, DLIR_M, and DLIR_H), ASiR-V from 10% to 100% in 10%-increment, and filtered back-projection (FBP). Signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) determined objective image quality. Subjective image quality was assessed with a 4-point Likert scale. Concordance between reconstruction algorithms was assessed by Pearson correlation coefficient.

Results

DLIR algorithm did not impact vascular attenuation (P ≥ 0.374). DLIR_H showed the lowest noise, comparable with ASiR-V 100% (P = 1) and significantly lower than other reconstructions (P ≤ 0.021).

DLIR_H achieved the highest objective quality, with SNR and CNR comparable to ASiR-V 100% (P = 0.139 and 0.075, respectively). DLIR_M obtained comparable objective image quality with ASiR-V 80% and 90% (P ≥ 0.281), while achieved the highest subjective image quality (4, IQR: 4–4; P ≤ 0.001). DLIR and ASiR-V datasets returned a very strong correlation in the assessment of CAD (r = 0.874, P = 0.001).

Conclusion

DLIR_M significantly improves CCTA image quality and has very strong correlation with routinely applied ASiR-V 50% dataset in the diagnosis of CAD.
Wettability and Reactivity of Liquid Magnesium with a Pure Silver Substrate
Authors: Terlicka S. , Sobczak N. , Sobczak J. J. , Darłak P. , Ziółkowski E.
Published: February 2023

For the first time, experimental data on the high-temperature interaction of liquid Mg with pure Ag are presented. The study was performed by the sessile drop method and capillary purification procedure. The test was carried out under isothermal conditions at 720 °C in a protective atmosphere of Ar + 5 wt.% H2. The solidified couple was subjected to detailed microstructural observations by scanning electron microscopy (SEM) coupled with energy-dispersive x-ray spectroscopy (EDS). Under the used conditions, immediately after contact with the Ag substrate, liquid Mg drop showed a good wetting (θ0 ~ 65°) followed by fast spreading over the substrate in subsecond time to form the final contact angle of θf ~ 31°.SEM/EDS analysis showed that θf is apparent because of a deep crater (200 μm) formed in the substrate under the drop by the dissolution of Ag in liquid Mg. SEM/EDS observations of complex structural transformations in the Mg/Ag couple due to high-temperature contact and subsequent cooling are in good agreement with the Ag-Mg phase diagram. Besides substrate dissolution, the interaction between liquid Mg and solid Ag at 720 °C is accompanied with the alloying of the Mg drop with Ag and the formation of a continuous layer of the β-AgMg phase at the Mg/Ag interface. During cooling, the chemical composition of the Mg(Ag) drop continuously changes, and this process is followed by the formation of the β-AgMg phase by secondary precipitation from Ag-saturated liquid, a partial transformation of the β-AgMg to ε′-Ag17Mg54 phase by peritectic reaction, followed by the solid-state transformation of the ε′-phase to the ε-AgMg3 phase, and finally, the solidification of residual liquid in the form of the two-phase eutectic mixture of AgMg4 + (Mg). The results obtained suggest that a very good wetting and fast spreading observed experimentally for the Mg/Ag couple is caused by high reactivity between liquid Mg and Ag substrate leading to the combined effect of two reactive wetting mechanisms, i.e. through dissolutive wetting and wetting through the formation of the interfacial reaction product (β-phase).
Alteration of the Gut Microbiota in Missed Abortion
Authors: Chen Yi , Chen Xianqian , Chen Pingyu , Chen Xiuxia , Pan Lin , Han Lihong , Zhu Tang
Published: February 2023

There is a symbiotic relationship between gut microbiota and human beings. Imbalance of the gut microbiota will cause pathological damages to humans. Although many risk factors are associated with missed abortion (MA), the pathological mechanism of it is still unclear. Here, we analyzed gut flora of the patients with MA by S16 high-throughput sequencing. The possible pathogenic mechanisms of the MA were explored. Fecal samples from 14 healthy controls and 16 MA patients were collected to do 16S rRNA gene high-throughput sequencing analysis. The abundance of the Bacteroidetes, Proteobacteria, Actinobacteria, Escherichia, Streptococcus_ Salivarius, and Lactobacillus was significantly reduced in the MA group, while, the abundance of the Klebsiella was significantly increased in the MA patients. The Ruminococcaceae and [Eubacterium]_coprostanoligenes_group were found only in the specimens of the MA patients. The Fabrotax function prediction analysis showed that four photosynthesis function bacteria (cyanobateria, oxygenic_photoautotrophy, photoautotrophy, and phototrophy) only existed in the MA group. In the analysis of the BugBase microbiome function prediction, the Escherichia of the MA group is significantly reduced compared to that of the healthy controls in the items of that Contains_Mobile_Elements, Facultatively_Anaerobic, Forms_Biofilms, Potentially_Pathogenic.png, Gram_Nagative, and Stress_Tolerant_relabundance. These alterations may affect the stability of the host's immune, neural, metabolic and other systems by interfering with the balance of the gut microbiota or by the metabolites of those bacteria, causing the MA. This study explored the possible pathogenic factors of the gut microbiota of the MA. The results provide evidence to figure out the pathogenesis of the MA.
Reaction mechanism reduction for ethylene-fueled supersonic combustion CFD
Authors: Kobayashi Kan , Tomioka Sadatake , Takahashi Masahiro , Kodera Masatoshi
Published: February 2023

CHEMKIN-Pro was used to build a custom-made reduced reaction mechanism for a 3D simulation of C2H4/Air reaction in a supersonic combustion ramjet (scramjet) combustor for the JAXA S-520-RD1 flight test performed on 24 July 2022. It was also attempted to reproduce the effect of unavoidable H2O vitiation in the facility (ground) test on combustion characteristics. USC Mech II (a 111-species mechanism) was applied as the master mechanism. First, 1D simulation was conducted by applying a plug flow reactor model; 34-, 23-, 20-, 18-, and 19-species mechanisms were suggested as candidates for reduced mechanism. Then, 0D ignition delay simulation by applying a perfectly stirred reactor model by CHEMKIN-Pro, 2D reacting flow simulation by CRUNCH CFD, and 3D reacting flow simulation by RANS were performed to select the most suitable reduced mechanism. The 20-species (96-elementary-reactions) mechanism consisted of H2, O2, N2, H2O, CO2, CO, H, O, OH, HO2, CH2, CH2*, CH3, HCO, CH2O, CH3O, C2H2, C2H3, C2H4, and CH2CHO and was selected as the best-reduced reaction mechanism for C2H4-fueled 3D simulation under the flight and facility conditions corresponding to the RD1 flight test.
Static analysis of prestressed micropile-raft foundation with varying lengths resting on sandy soil
Authors: Ebadi-Jamkhaneh Mehdi , Kontoni Denise-Penelope N.
Published: February 2023

The micropile-raft system is used in the foundation system of buildings due to the combination of the advantages of raft foundations and micropiles. In this paper, the numerical model was calibrated and validated with a field test, and then several parametric studies were performed. The overarching aim of the study is to determine the efficiency of different arrangements of micropiles and the effects of these parameters on the behavior of piled raft foundations in sandy soil. Parameters including diameter, length, and distance of micropiles from each other were considered in the analyses. Prestressed rebars have been used to increase the load-bearing capacity and prevent premature buckling under severe compressive load. Therefore, to compensate for the weak bearing capacity of the raft foundation, a micropile system equipped with prestressed rebars was considered to increase the bearing capacity of the foundation. The results revealed that using a set of micropiles with a diameter of 30 cm and a length of 10 m had the maximum efficiency among other models. Furthermore, an innovative arrangement of micropiles was proposed in which a set of micropiles with a length of 30 m was placed at the middle region of the foundation, and in the peripheral area of the foundation, several short micropiles were used.
Computation of Large-Dimension Jordan Normal Transform via Popular Platforms
Authors: Shi Chunxiao , Chen Yong-Cong , Xiong Xia , Ao Ping
Published: February 2023

We address the practical issue that popular computation platforms like Matlab$$^{\copyright }$$

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are unable to perform the Jordan normal (canonical) form J and the associated transform matrix P on a high-dimension matrix. Given the knowledge of the eigenvalues and eigenvectors of n-square matrix A obtained on these platforms, we present an efficient algorithm of Jordan transform with detailed computation steps. The efficiency is demonstrated by comparing the simulation results of 11 examples with varying orders of n to that computed by the symbolic-based and capacity-limited routine $$[P, J] = {\textsf {jordan}}(A)$$

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P
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J
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=
jordan
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A
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in Matlab$$^{\copyright }$$

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. Applications in stochastic dynamics are addressed.
A Course in Environmental Economics
Authors: Phaneuf Daniel J. , Requate Till
Published: February 2023

This unique graduate textbook offers a compelling narrative of the growing field of environmental economics that integrates theory, policy, and empirical topics. Daniel J. Phaneuf and Till Requate present both traditional and emerging perspectives, incorporating cutting-edge research in a way that allows students to easily identify connections and common themes. Their comprehensive approach gives instructors the flexibility to cover a range of topics, including important issues - such as tax interaction, environmental liability rules, modern treatments of incomplete information, technology adoption and innovation, and international environmental problems - that are not discussed in other graduate-levels texts. Numerous data-based examples and end-of-chapter exercises show students how theoretical and applied research findings are complementary, and will enable them to develop skills and interests in all areas of the field. Additional data sets and exercises can be accessed online, providing ample opportunity for practice. For more information, visit the book's website at http://phaneuf-requate.com/.
Surface Artifact Scatters, Data Collection, and Significance
Authors: Douglass Matthew J. , Wandsnider LuAnn , Holdaway Simon J.
Published: February 2023

The three authors research surface archaeological records dominated by low-density scatters and isolated artifacts, archaeological phenomena frequently encountered during cultural resource management (CRM) projects in areas of the United States and Australia. We each began researching surface artifact scatters for different reasons but converged on approaches that emphasize the formation of these forms of archaeological deposits. Through a variety of projects, we asked a common set of questions about the processes that both buried and exposed these materials, the methods needed to obtain a chronology in different regions, and the ways we might interpret artifacts found together in different densities. Answering these questions led to the collection and analyses of datasets in innovative ways and the questioning of a number of archaeological categories often thought of as fundamental for archaeological research. Here, we review examples of our respective research and consider the implications for CRM projects dealing with surface lithics.
The National Cultural Resources Information Management System (NCRIMS)
Authors: Halford F. Kirk , Ables Dayna M.
Published: February 2023

Despite making great strides over the past 50 years, cultural resources data management and synthesis continues to be elusive and nonstandardized, with each state and agency developing disparate systems that do not easily mesh. The Bureau of Land Management (BLM) has embarked on a national initiative by creating a National Cultural Resources Data Standard (NCRDS) that works to address many long-standing data organization issues. The NCRDS allows for the application of more rigorous data management principles that facilitate landscape-level planning and data modeling on BLM-administered lands across the western United States. The NCRDS and associated National Cultural Resources Information Management System (NCRIMS) contains normalized data from 11 western State Historic Preservation Offices (SHPOs) and BLM data stores. NCRIMS is a web-based application hosted by the BLM's National Operations Center (NOC) Enterprise Geographic Information System (EGIS). NCRIMS allows for high-level planning during local, regional, and multistate project analyses and undertakings, facilitating consideration of cultural heritage values early in the planning process versus late stages as has been traditional. This allows the BLM to more proactively, effectively, and efficiently answer data calls and inform agency decision-makers on possible impacts to cultural heritage resources by proposed or ongoing agency actions.
Will It Ever Be FAIR?
Authors: Nicholson Christopher , Kansa Sarah , Gupta Neha , Fernandez Rachel
Published: February 2023

A fundamental task of archaeology is to address challenging scientific questions related to the complexity of human societies. If we are to systematically understand the processes that affect human societies on multiple spatial and temporal scales, research leveraging existing archaeological data is essential. However, only a fraction of the data from archaeological projects are publicly findable or accessible, let alone interoperable or reusable. This is the case despite statements of disciplinary ethics, availability of capable technologies for data stewardship, publications providing guidance, and legal mandates. This article introduces the FAIR principles for data stewardship in North American archaeology, which state that data should be Findable, Accessible, Interoperable, and Reusable. We call for efforts to promote widespread adoption of the FAIR and CARE (Collective benefit, Authority to control, Responsibility, and Ethics) principles among professional organizations, publishers, data repositories, and researchers. We also call for adoption and implementation of requirements to adhere to these principles by governmental agencies, funding bodies, and other regulators of archaeological research. Ultimately, adoption of the FAIR principles in an ethical framework contributes to our understanding of our human experience and can lead to greater integration and reuse of research results, fostering increased partnerships between academia and industry.
Derivational networks of onomatopoeias in English and Slovak
Authors: Körtvélyessy Lívia , Andrej Ľubomír
Published: February 2023

This article presents research into derivational properties of onomatopoeias in English and in Slovak. Onomatopoeias are defined narrowly in our approach, being restricted to the direct imitation of sounds of extra-linguistic reality. Our sample of 40 onomatopoeic words consists of two sound types: the sounds of animals and the sounds resulting from various falls, strokes, and bursts. A derivational network was produced for each such word. The evaluation parameters comprise derivational capacity, maximum derivational network, saturation value, number of derivation orders, most productive semantic categories by order of derivation, typical combinations of semantic categories, and derivational processes. An evaluation of the networks enabled us to answer the question of whether onomatopoeias are productive word-formation bases, to compare the two Sound Types, and to compare onomatopoeia-based networks to those based on non-iconic vocabulary. These results contribute to a better understanding of the word-formation systems in the compared languages and of the status of onomatopoeias with regard to non-iconic vocabulary.
Joining forces: the value of design partnering with operational research to improve healthcare delivery
Authors: Lamé Guillaume , Crowe Sonya , Komashie Alexander , Royston Geoff
Published: February 2023

A wide range of disciplines are directing their methods and tools to help address the challenges of healthcare. Chief among these are design and operational research (OR). Though they have much in common, these two disciplines have existed in isolation for most of their history and there is currently a gulf between the two research communities. In this position paper, we rapidly review the contributions of design and OR in healthcare. We then identify similarities and complementarities between the two disciplines and communities when they consider healthcare systems. Finally, we propose practical steps to enable better collaboration. Our focus is on finding ways in which the two disciplines complement each other. When applying design to healthcare services, designers may wish to learn from OR, which has a long history of supporting improvements in healthcare organisation and services, particularly using quantitative data and analysis and modelling methods. In return, design has distinctive qualities that could augment the OR approach, such as its emphasis on wide and creative search for potential solutions, and iterative co-production and prototyping of solutions with clients. Better collaboration will require a coordinated effort but could yield a more comprehensive and effective approach to improving healthcare systems.
Effect of tabs on the shear layer dynamics of a jet in cross-flow
Authors: Morse Nicholas , Mahesh Krishnan
Published: February 2023

Direct numerical simulations (DNS) of a jet in cross-flow (JICF) with a triangular tab at two positions are performed at jet-to-cross-flow velocity ratios of

$R = 2$

and

$4$

with a jet Reynolds number of 2000 based on the jet's bulk velocity and exit diameter. The DNS and dynamic mode decomposition show the sensitivity of the tab's effect on the jet upstream shear layer (USL) structure and cross-section to

$R$

, echoing the experimental discoveries of Harris et al. (J. Fluid Mech., vol. 918, 2021). Furthermore, DNS reveals that the presence of a tab placed on the upstream side of the nozzle significantly modifies the USL through production of streamwise vortices that curl around the spanwise vortex tubes originating from the primary instability of the USL. This provides an explanation for the improvement in mixing that has been associated with an upstream tab. The streamwise vortex structure shows remarkable similarities to the ‘strain-oriented vortex tubes’ observed for disturbed plane shear layers by Lasheras & Choi (J. Fluid Mech., vol. 189, 1988, pp. 53–86). For both

$R$

cases, the USL instability is delayed, the jet penetration is reduced, and the jet cross-section is flattened, although the tab has a less pronounced effect on the USL structure at higher velocity ratios, where the formation of the streamwise vortices is delayed. In contrast, a tab placed 45

$^\circ$

from the upstream position produces significantly different effects compared with the upstream tab. At

$R = 4$

, the jet cross-section is significantly skewed away from the tab and a tertiary vortex is formed, as observed in past studies of round JICFs at relatively high

$R$

and low Reynolds numbers. The ability of the tab to produce a controllable steady-state tertiary vortex has implications for a variety of applications. The 45

$^\circ$

tab produces asymmetric effects in the wake of the jet at

$R = 2$

, but the effect on the jet cross-section is much smaller, highlighting the sensitivity of jets at high

$R$

to asymmetric perturbations.