bluuebunny/crossref_metadata_2025 huggingface dataset:
Molecular Evolution and Genotype Shift of Porcine Circoviruses Type 2 in Vietnam
Authors: Lai Danh Cong , Le Dung Khanh Thi , Nguyen Trung Huu , Thach Manh , Hue Vo Thi , Le Phan , Ngo Tram Ngoc Thi , Nguyen Nam Minh , Do Duy Tien
Published: July 2024

Porcine Circovirus Type 2 (PCV2), a significant pathogen in the global swine industry, causes Porcine Circovirus Associated Diseases (PCVAD), contributing to substantial economic losses. This study investigates the genetic diversity and evolutionary dynamics of PCV2 in Vietnam from 2022 to 2023. We sequenced and analyzed 47 PCV2 genomes isolated from swine farms across Vietnam, revealing predominant circulation of PCV2d (80.85%) followed by PCV2b (19.15%). Phylogenetic analysis identified PCV2 genotypes PCV2a, PCV2b, PCV2d, PCV2g, and PCV2h circulating in Vietnam, with PCV2d emerging as the most prevalent genotype. Comparison with historical data highlighted genotype shifts from PCV2b to PCV2h in 2008 and then to PCV2d in 2014. Regional analysis indicated varied PCV2 epidemiological patterns between northern and southern Vietnam. Amino acid substitutions within the capsid protein were identified, predominantly in antigenic regions critical for immune recognition, suggesting implications for vaccine efficacy. Positive selection analysis identified multiple sites under evolutionary pressure, indicating ongoing adaptation of Vietnamese PCV2 strains. These findings enhance understanding of PCV2 dynamics in Vietnam and underscore the importance of continuous surveillance and adaptive management strategies in controlling PCV2-associated diseases in swine populations.
Detection and enhancement of latent fingerprint by powder method using bio-synthesized spherical-shaped Bismuth Oxychloride nanoparticles
Authors: Choudhary Nityanand
Published: July 2024

Green fluorescent nanoparticles Bi0.95Tb3+0.5Li0.3OCl were successfully synthesized through the solution combustion method using Mimosa pudica as a biofuel. The nanoparticles, annealed at 10000C for three hours, were characterized by X-ray diffraction, revealing a Body Centered Cubic structure. When excited with a 980 nm diode laser, the phosphor emitted a green color. The energy gap of the nanophosphor was estimated to be 3.64eV using diffuse reflectance spectra. High contrast latent fingerprints were developed on porous and semi-porous surfaces by exciting the phosphors with a 980nm diode laser. These fingerprints were compared with a commercially available green luminescent fingerprint. The synthesized nano phosphor proved to be a viable alternative to traditional luminescent powders for forensic applications, offering a simple, fast, highly sensitive, and eco-friendly method for detecting and enhancing fingermarks related to forensic materials.
Transcriptomic analysis identifies enrichment of cAMP/PKA/CREB signaling in Invasive Lobular Breast Cancer
Authors: Narayanan Susrutha Puthanmadhom , Wedn Abdalla , Shah Osama Shiraz , Chen Jian , Brown Daniel D , McAuliffe Priscilla , Steffi Oesterreich , Lee Adrian V.
Published: July 2024

OBJECTIVE
Invasive lobular breast cancer (ILC) is the most common special type of breast cancer and has unique clinicopathological and molecular hallmarks that differentiate it from the more common invasive carcinoma – no special type (NST). Despite these differences, ILC and NST are treated as a single entity and there is a lack of ILC-targeted therapies. To fill this gap, we sought to identify novel molecular alterations in ILC that could be exploited for targeted therapies.
METHODS
Differential gene expression and Geneset Enrichment and Variation analyses were performed on RNA-seq data from three large public breast cancer databases – the Sweden Cancerome Analysis Network-Breast (SCAN-B; luminal A ILC N = 263, luminal A NST N = 1162), The Cancer Genome Atlas (TCGA; luminal A ILC N = 157, luminal A NST N = 307) and Molecular Taxonomy of Breast Cancer International Consortium (METABRIC; luminal A ILC N = 65, luminal A NST N = 533). Pathways enriched in overlapping differentially expressed genes from these datasets were clustered using Jaccard similarity to identify pathways enriched in ILC. The cAMP/PKA/CREB signaling was studied in ILC, ILC-like and NST cell lines and patient-derived organoids (PDOs) using forskolin, an activator of the pathway.
RESULTS
Clinicopathological features of patients with ILC and NST in SCAN-B were similar to prior population-based studies. There was a consistent pattern of up-regulation of cAMP/PKA/CREB related signaling in ILC compared to NST in SCAN-B, TCGA and METABRIC. Treatment with forskolin resulted in a greater increase in phospho-CREB in ILC cell lines and organoids than NST. CRISPR deletion of CDH1 in NST cell lines did not alter response of cells to forskolin as measured by phospho-CREB. Forskolin treatment caused growth inhibition in ILC and NST, with ILC cell lines being more sensitive to forskolin-mediated growth inhibition.
CONCLUSION
In three separate datasets, cAMP/PKA/CREB signaling was identified to be higher in ILC than NST. This in silico finding was validated in cell line and organoid models. Loss of CDH1 was not sufficient to mediate this phenotype. Future studies should investigate the mechanisms for differential cAMP/PKA/CREB signaling and the potential for therapeutic targeting in patients with ILC.
A Comprehensive Survey of Scoring Functions for Protein Docking Models
Authors: Shirali Azam , Stebliankin Vitalii , Kark Ukesh , Shi Jimeng , Chapagain Prem , Narasimhan GIri
Published: July 2024

Background: While protein-protein docking is fundamental to our understanding of how proteins interact, scoring protein-protein complex conformations is a critical component of successful docking programs. Without accurate and efficient scoring functions to differentiate between native and non-native binding complexes, the accuracy of current docking tools cannot be guaranteed. Although many innovative scoring functions have been proposed, a good scoring function for docking remains elusive. Deep learning models offer alternatives to using explicit empirical or mathematical functions for scoring protein-protein complexes.
Results: In this study, we perform a comprehensive survey of the state-of-the-art scoring functions by considering the most popular and highly performant approaches, both classical and deep learning-based, for scoring protein-protein complexes.
Conclusions: We evaluate the strengths and weaknesses of classical and deep learning-based approaches across seven public and popular datasets to aid researchers in understanding the progress made in this field. Keywords: Computational structural biology, Protein-protein interactions, Scoring functions, Molecular docking, Deep learning, Protein surface properties
Introducing AIDx, The Physician's AI Copilot
Authors: Alwakeel Alan
Published: July 2024

The dynamic environment of medicine, like the Emergency Department, challenges physicians with an influx of patient data and the need for swift diagnosis and treatment under high-pressure situations. Furthermore, there are numerous AI models developed for medical applications that, despite their potential, rarely see hospital implementation because they fail to integrate into pre-existing clinical workflows. Addressing these challenges, I developed AIDx, a state-of-the-art AI-powered system designed to streamline clinical decision-making, provide accurate disease prediction and treatment planning, offer novel approaches for personalized patient healthcare, and serve as a hub for AI-assisted medical analysis. Unlike standalone systems, AIDx integrates seamlessly with a hospital's pre-existing electronic health records and automatically leverages supplemental tools (like an up-to-date medical knowledge database and capability-enhancing AI models), offering physicians a unified platform for comprehensive AI assistance. I trained AIDx on 400,000 de-identified patient charts and evaluated it on 7,000 medical exam questions, achieving a remarkable accuracy of 83.61% that rivals the performance of industry-leading models like Google's Med-PaLM 2 and OpenAI's GPT-4 with significantly fewer parameters (a model size metric), using only 46.7 billion compared to their 340 billion and 1.7 trillion. This parameter efficiency translates into feasible on-premises deployment, high-speed processing, and adaptability across clinical settings. AIDx also significantly enhances patient-physician communication, simplifying medical terminology and facilitating multilingual translation. Ultimately, AIDx represents a transformative integration of AI in medicine, establishing an unprecedented standard for personalized, reliable, and streamlined patient care, elevating the quality of healthcare, and enhancing the lives of patients and physicians alike.
Digging deeper into the impacts of different soil water systems on the date palm root architecture and associated fungal communities
Authors: Robin-Soriano Alexandre , Vincent Bryan , Maurice Kenji , Battesti Vincent , Boukcim Hassan , Ducousso Marc , Gros-Balthazard Muriel
Published: July 2024

In arid regions, excessive water use threatens agricultural sustainability and overall livelihoods. It is essential to minimize water consumption to address these issues. Date palm (Phoenix dactylifera L.) is an emblematic crop of arid regions and a major water consumer. Tailoring current irrigation systems into new, water-efficient systems could help cope with the water consumption of this crop. Microbial communities associated with plants are essential for agricultural sustainability and could improve the water use efficiency in regions threatened by water scarcity. These communities should thus be seriously taken into account when adapting agrosystems to the current global change setting. However, no information is presently available on the effects of these modifications on date palm microbial communities. This study highlights the impact of different soil water systems (flooding and drip irrigation, natural conditions and abandoned farms) on date palm root fungal communities at different soil depths. The findings revealed that the soil water systems had a marked impact on fungal communities and that drip irrigation reduced the fungal diversity but increased the abundance of arbuscular mycorrhizal fungi. We showed that these effects were similar at all sampling depths. Finally, as the root architecture is a major determinant of water uptake, we reveal different behaviors of the root architecture under these different soil water systems to 160 cm depth. The findings of this study give new insights into the date palm root architecture and associated fungal communities, particularly in the context of the water availability crisis, which drives the adaptation of agricultural systems.
Diagnostic Accuracy of Ultrasound in Intensive Care Patients with Undifferentiated Shock: A Systematic Review and Meta-analysis.
Authors: Karigowda Lohith , Gupta Bhavna , Deshpande Kush , Elkady Hatem
Published: July 2024

Background:
Shock is a common condition in intensive care, affecting approximately one-third of patients in the intensive care unit (ICU).1 The standard method to diagnose shock in the ICU is based on clinical, hemodynamic, and biochemical signs. In the last decade, ultrasound has become the preferred tool for shock identification and treatment. Therefore, we performed a systematic review and meta-analysis to determine the diagnostic accuracy of ultrasound in patients with undifferentiated shock in the Intensive Care Department.
Method:
We searched PubMed, Embase, Scopus, Cochrane Central Register and Google scholar for Controlled trials published until June 2023. Two intensivists independently screened the articles for full-text reviews and assessed the quality of the selected studies using the Quadas-2 tool. We included a prospective study involving critically ill patients with undifferentiated shock which utilise ultrasound to diagnose the type of shock. The objective was to determine the accuracy of ultrasound in identifying shock type.
Results:
Of the 7287 articles, four met the study inclusion criteria for the meta-analysis. Pooled positive likelihood ratio values ranged from 8.8 (95% CI 2.4 to 32.37) for distributive shock to 137.56.54 (95% CI 27.76 to 681.64) for obstructive shock. The summary receiver operating characteristic (SROC) for cardiogenic and obstructive shock had an AUC (area under the curve) of 0.99, for hypovolemic and mixed shock was 0.5, and for distributive shock was 0.76, Pooled negative likelihood ratio values ranged from 0.05 (95% CI 0.010 to 0.24) for cardiogenic shock to 0.22 (95% CI 0.127 to 0.38) for mixed-etiology shock.
Conclusion:
Our meta-analysis showed that ultrasound in intensive care patients with undifferentiated shock can help diagnose obstructive and cardiogenic shock. However, this may not be helpful for other types of shocks.
Development Modul Guided Inquiry Integrated Augmented Reality (M-GIIAR) to Improve Student’s Science Process Skills on Mechanical Wave Material
Authors: Nindyatami Zulfi , Rochman Chaerul , Chusni Muhammad Minan
Published: July 2024

Science learning skills need to be applied at every stage of learning. However, students do not have good science process skills (SPS). Learning media is also needed to support modern and engaging science learning skills. Research using the ADDIE model, a sample of 30 students in class XI MIPA at SMAN 1 Wanayasa. The average validity test results are 82.40%. The results of implementing Authentic assessment based on Teaching and Learning Trajectory with Student Activity Sheets increased from each meeting; the average value was 85.58% with good effectiveness. The results of the N-Gain pretest and posttest based on the science process skills indicator obtained an average N-Gain result of 0.57 with a moderate interpretation. The researcher used a nonparametric hypothesis test with the Wilcoxon sign rank type. The results of the hypothesis test obtained acceptance of the alternative hypothesis (Ha), meaning that there was an increase experienced by students in SPS  in mechanical wave material. Based on several aspects, student responses obtained an average of 70.07% in the good and positive category.
Effect of Physics Inquiry Learning with Low-cost Experiment Tool on Students’ Problem-solving Skills and Self-efficacy
Authors: Rizki Iqbal Ainur , Khoir Ermia Fadilata , Nikmah Fatihatun , Prahani Binar Kurnia , Hariyono Eko
Published: July 2024

The low problem-solving skills and self-efficacy of students in physics learning significantly impact their overall learning processes and outcomes. In order to address this issue, an inquiry learning model was implemented, along with the low-cost experiment tool. This learning model is designed to be valid and effective in enhancing students' problem-solving skills and self-efficacy. The research followed a non-equivalent control group design and involved 66 students to ensure the development of a high-quality learning model that meets the required standards and criteria. By utilising learning instruments, such as students' response questionnaires, problem-solving pre- and post-tests, and self-efficacy questionnaires, the focus of the physics topic in this research was the simple mathematic pendulum. The validity test results show that the learning instrument has high validity and reliability criteria, making it feasible to use in physics learning. Furthermore, the statistical effectiveness test results show that this learning model is effective in improving students' problem-solving skills and self-efficacy. As students engage in hands-on investigations and collaborate on meaningful projects, they are prompted to apply critical thinking and decision-making skills, directly contributing to the development of effective problem-solving strategies. The intrinsic motivation derived from successfully navigating the challenges of inquiry learning, coupled with the personal relevance of the content, nurtures students' confidence in their abilities, ultimately strengthening their self-efficacy as independent and capable learners. Research implies the development of innovative learning models, effectively enhancing students' PSS and SE.
Evaluation of falling risk and quality of life in the elderly
Authors: Tekin Ömer Faruk , Arık Ece , Yılmaz Muammer , Arıkan İnci
Published: July 2024

Aim: The aim of this study is to determine the risk of falling, which is one of the conditions that threaten the health of the elderly, and to evaluate its relationship with quality of life.

Methods: A cross-sectional study was conducted in a province located in the west of Türkiye between September and November 2022. The questionnaire was conducted face-to-face in family health centers after obtaining informed consent from the participants. In this study, a questionnaire including sociodemographic characteristics, features related to falls, the fall risk for the older in the community (FROP-Com) screening scale, and the EQ-5D quality of life scale was used.

Results: The study was completed with 413 participants. The prevalence of falls within the last year in the study group was 21.1%. According to FROP-Com screen; 8.0% of the participants had a low fall risk and 92.0% had a high fall risk. The median EQ-5D index score was 0.7 (minimum=-0.2; maximum=1.0). FROP-Com fall risk was accepted as the dependent variable, the risk of falling; It was found that it increased 2.5 times in those who did not exercise, 5.1 times in those who did have balance problems, and 3.6 times in those who used assistive devices compared to those who did not.

Conclusion: In the Central District of Kütahya, one out of every five people over the age of 65 had a history of falling within the last year. In the study, it is remarkable that there is a relationship between exercise status and the risk of falling. Falls can be prevented or reduced by increasing exercise status.
The effect of postnatal weight gain and other risk factors on severe retinopathy of prematurity
Authors: Kırık Furkan , Aşık Nacaroğlu Şenay , Salihoğlu Özgül , Kunduracı Merve Sena , Onur İsmail , Yiğit Ulviye
Published: July 2024

Aim: To assess the effect of postnatal weight gain characteristics and multiple risk factors on treatment-required retinopathy of prematurity.

Methods: The medical records of preterm infants who were followed up for retinopathy of prematurity in a tertiary referral center were retrospectively reviewed. Infants were grouped as Treatment(-) (retinal maturation without treatment) and Treatment(+) (treatment required). Retinopathy of prematurity findings, weight gain and weight gain rates at the 4th and 6th weeks, and clinical features were noted. The best cut-off points for the weight gain and weight gain rate were assessed with the area under the receiver operating characteristic curve. Risk factors were determined by the logistic regression model.

Results: Twenty-eight of 201 preterm infants (13.5%) were in the treatment (+) group. Birth weight, gestational age, weight gain, and weight gain rate at the 4th and 6th weeks were lower, the duration of oxygen therapy and hospitalization was longer, and a history of bronchopulmonary dysplasia, necrotizing enterocolitis, prolonged mechanical ventilation, and erythrocyte transfusion was more common in the treatment (+) group (p
Advances in Iron Deficiency Anaemia Management: Exploring Novel
Drug Delivery Systems and Future Perspectives
Authors: Saini Muskan , Trehan Karan , Thakur Shubham , Modi Anuj , Jain Subheet Kumar
Published: July 2024

Iron Deficiency Anaemia (IDA) is a prevalent global health issue characterized by inadequate iron levels in the body, leading to impaired red blood cell production and subsequent
anaemia. Traditional treatment approaches for IDA, such as oral iron supplementation, often encounter challenges related to poor compliance, gastrointestinal side effects, and variable absorption rates. As a result, there is a growing interest in exploring novel drug delivery systems to enhance iron therapy efficacy and patient outcomes. This review discusses recent advances in IDA
management, focusing on developing and utilizing innovative drug delivery systems for iron supplementation. Various strategies, including nanoformulations, microparticles, liposomes, and hydrogels, are explored for their potential to improve iron bioavailability, reduce adverse effects,
and optimize therapeutic outcomes. Furthermore, promising strategies for the future management
of IDA are explored, including the utilization of advanced technologies such as targeted drug delivery systems, controlled release mechanisms, and combination therapies. The integration of these novel drug delivery systems with advancements in diagnostics, personalized medicine, and patient-centered care holds great potential to revolutionize the management of IDA and improve the
quality of life for individuals affected by this condition.
Search for Novel Therapeutic Targets of Type 2 Diabetes Mellitus
Authors: Kumar Yadav Nitesh , Mazumder Rupa , Rani Anjna , Kumar Arvind , Kaur Jaskiran
Published: July 2024

Background:

Type 2 Diabetes (T2D) is a chronic metabolic disease characterized by
hyperglycemia and carries a high risk of numerous complications. The rising prevalence of this
lifelong condition affects millions globally, demanding novel therapeutic strategies. Existing medications
targeting insulin and other pathways often pose limitations like suboptimal glycemic control,
side effects, and high costs. Novel therapeutic targets are crucial for developing better treatments
and potentially reducing side effects associated with previous drugs.

Objective:

This paper aims to comprehensively review and analyze potential targets for the treatment
of diabetes mellitus.

Method:

We conducted a comprehensive search of MEDLINE, Scopus, Science Direct, PubMed,
and Google Scholar databases. Search terms included “diabetes mellitus”, “novel targets”, “drug
discovery”, “gene expression” and “molecular pathways”. We identified over 175 published articles
exploring novel therapeutic targets for DM.

Results:

The review presented a detailed analysis of promising anti-diabetic targets. These targets
encompass various pathways and mechanisms, including insulin signaling, Glucose signaling, inflammation
and oxidative stress, gut microbiome, and epigenetic modifications. Several promising
candidates emerged, such as Glucokinase activators, GPCRs modifiers, Fructose-1,6-bisphosphatase
antagonists, Protein tyrosine phosphatase 1B antagonist, 11β-Hydroxysteroid, andDehydrogenase
antagonists. Potential therapeutic agents targeting these emerging targets will be discussed,
along with their mechanisms of action and preclinical/clinical evidence.

Conclusion:

By identifying and comprehensively analyzing new therapeutic targets, this review
intends to provide insights for the development of more effective and efficient diabetes management
strategies. The information presented can guide future research initiatives and drug development
efforts toward novel and promising anti-diabetic therapies.
Formulation and Characterization of Emulgel Lornoxicam Containing Lemon Grass Oil as Penetration Enhancer
Authors: Kumari Vibha , Bajpai Meenakshi
Published: July 2024

Introduction:

Emulgel dosage form is an advanced form of transdermal drug de-livery. It is a combination of emulsion and gel in a definite ratio. Emulsions are incorporated into the gel with proper mixing. The emulsion present in emulgel can be either oil/water or water/oil, which is thickened by mixing it with a gelling agent.

Material and Methods:

On the basis of the solubility of lornoxicam in various oils, a surfactant and a co-surfactant were selected for further research. For the preparation of emulgel, the emulsion was prepared with Smix (surfactant and co-surfactant) in a ratio of 1:2. The prepared emulsion was incorporated into different concentrations of carbapol 934 in a 1:1 ratio to make a homogenous emulgel.

Results:

The emulgel was inspected visually to see if it had any phase behaviour, spreadabil-ity, or grittiness by applying it to a slide. All formulations were evaluated for pH, physical properties, drug content, spreadability, extrudability, swelling index, viscosity, and centrifu-gation. Franz diffusion cell was used to perform in-vitro release of formulation with the help of egg membrane. Among all formulations, F3 showed 83% release after 6 hours and showed acceptable physical properties like homogeneity, colour, consistency, pH value, spreadability, extrudability, and drug content.

Discussion:

Thus, emulgel can be regarded as a more feasible drug delivery system for hydrophobic drugs (lornoxicam) than the currently marketed formulation. Optimized emulgel formulation consists of a microemulsion of lornoxicam, 1% of carbopol 934, propylene glycol, sodium benzoate, lemon grass oil, glycerin, and distilled water. In the in-vitro release studies, pH 7.4 phosphate buffer emulgel formulation (F3) showed 83% after 6 hours. Emulgel was found to be stable under stable conditions.

Conclusion:

The emulgel of the poorly water-soluble drug (lornoxicam) was formulated. The components and their optimum ratio for the formulation of microemulsion were obtained by solubility studies and droplet size analysis. Thus, microemulsion can be regarded as a more feasible dose delivery system for lornoxicam than the currently marketed tablet, capsule, and injection formulations. Optimized microemulsion of lornoxicam was incorporated into the gel base. Therefore, it may be concluded that emulgel of lornoxicam can be used as a controlled-release dosage form of the drug for local application in rheumatoid arthritis.
The Impact of Yoga and Meditation on Mental and Physical Well-being
Authors: Divya Sharma  , B R Sharma
Published: July 2024

Background: Meditation that has been a practice for millennia in the present era has gained immense popularity as a stress-coping tool and overall health management and improvement method. Research significantly supports meditation efficacy, revealing beneficial brain and biological changes, leading to improved mental and physical well-being.[1] Methods: Based on an extensive review of scholarly literature about Stress, anxiety, depression mental and physical wellbeing, the present paper has been composed to through light on the impact of meditation on Physical and mental wellbeing. Result: This paper aims to offer a comprehensive overview of the current research on the relationship between meditation and health. Conclusion: The discussion in this article revolves around the impact of meditation on various aspects of the human physiology, specifically heart rate, blood pressure, metabolic rate, cortical activity, and skin resistance. The effects of meditation on human mental health, including relaxation, systematic desensitization, retrieval of repressed memories, perception, memory, stress, depression, anxiety, sleep disturbances, and relaxation, are also examined. The text addresses the major conceptual issues that require serious attention from researchers in this area for future research.
Comparative analysis of Timira and Myopia: Insights from Ayurvedic and Modern Perspectives
Authors: Dinesh Kumar Jat  , Savita Pushkar  , Sunil Kumar Dhart  , Gulab Chand Pamnani  , Prabhakar Vardhana
Published: July 2024

This study delves into the intricate understanding of eye disorders, focusing on Timira from Ayurvedic literature and Myopia from contemporary medical knowledge. Timira, characterized by blurred vision progressing to blindness, correlates with the involvement of specific anatomical layers (Patalas) and doshic imbalances. Myopia, a common refractive error, manifests as blurred distance vision, with its classification based on etiological factors. Ayurvedic texts detail preventive and therapeutic approaches for Timira, including herbal remedies and systemic treatments. In parallel, modern management of myopia involves optical corrections and refractive surgeries. Through a comparative analysis, this research elucidates the similarities and disparities between these disorders, emphasizing the importance of interdisciplinary understanding for effective diagnosis and treatment strategies.
Amsaphalaka Marma - A Cadaveric Study
Authors: Omkumar V Kori  , Anju Thomas
Published: July 2024

There are total of 107 Marma which are vital points where there is a Sannipata of Mamsa, Sira, Snayu, Asthi, Sandhi along with the Prana resides. Among them Amsaphalaka Marma is Prusthagata Asthi Marma, two in number and Vaikalyakara type of Marma, located on Pristhavansa Ubhaya to (both side of vertebral column) and is related to Trika. Trauma to Amsaphalaka Marma results in Baahuswapa and Shosha. Here Marmabhighata Lakshan can act as predictors of the structures involved. In this study, an attempt is made to find out exact location of Amsaphalaka Marma and its relations with other anatomical structures with the help of cadaveric dissection. The study concludes that the location of Amsaphalaka Marma may be considered as just above the superior border of the spine of the scapula on either side of the vertebral column.
A study on the effect of Yoga Nidra on Anxiety in Pregnant Women of different Trimester
Authors: Ajay Kumar  , Megha Sahu  , Arti Yadav
Published: July 2024

Aim: Women who are pregnant frequently experience stress, anxiety, and anger. All women must go through this era of their lives, and pregnancy requires physical, psychological, and social modifications to adjust to a new role. This study assessed the impact of Yoga Nidra on anxiety in women who were pregnant across various trimesters. Methods: Twenty women in varying trimesters were chosen and participated in a 21-day Yog Nidra session. The Sinha Comprehensive Anxiety Test (SCAT) anxiety scale was used to gather the data, and the T-test was used to analyse it. Results: The findings demonstrated a significant change in the pregnant women's anxiety levels before and after the intervention (t=4.440, p= 0.00). Conclusion: Yog Nidra influenced reducing anxiety levels among pregnant women irrespective of the trimester. It is expected that pregnant women use Yoga relaxation to decrease anxiety.
Management of Liver Cirrhosis and Splenomegaly with Herbo-Mineral Formulations - A Clinical Case Study
Authors: Rajeswary Majhi  , Babita Dash  , Shubham Borkar
Published: July 2024

Cirrhosis of the liver is the last stage of liver disease in which scar tissue replaces healthy tissue by blocking the flow of blood through the organ and preventing it from working as it should. The major pathways leading to cirrhosis are hepatitis, fatty liver, portal and centrilobular fibrosis. In Ayurveda, it can be correlated with Udararoga (Yakrutodara). In the present case study, Liver cirrhosis was treated with herbomineral formulations (Arogyavardhini Vati, Rohitakarista and Patolakaturohinyadi Kashayam) and the result was found very effective on biochemical parameters and other sign and symptoms.
The Consequences of a Heart Condition: Acute Stroke and Limb Ischemia Secondary to Massive Intracardiac Thrombus in a Young Female with Dilated Cardiomyopathy
Authors: Lestari Defyna Dwi , Tri Tjahjono Cholid , Kurnianingsih Novi
Published: July 2024

Background: Dilated cardiomyopathy (DCM) is associated with the increased occurrence of left ventricular (LV) thrombosis caused by cardiac dysfunction. This condition is associated with significant mortality and morbidity because of its significance as a potential source of systemic emboli. We are reporting a case of Acute Stroke and Limb Ischemia in a Young Female Patient with DCM. Case Illustration: A 20-year-old female was referred to our hospital due to pain in her right lower extremities and weakness in her right limb. She had been diagnosed with peripartum cardiomyopathy five years earlier. A general physical examination found her right lower limbs to be cold and pulseless. A neurological examination revealed hemiparesis involving the right side of her body. The chest radiograph showed cardiomegaly. Electrocardiography indicated sinus rhythm with LVH. The transthoracic echocardiograms revealed significant LV systolic failure with a massive thrombus at LV. The Duplex ultrasound showed a thrombus at the right dorsal pedis artery, and a head CT scan revealed an acute infarct. The patient was started on heparin and bridged with warfarin 5mg orally daily, and she was uneventfully discharged after one week. Conclusion: DCM had been associated with thrombosis, stroke, and an increased risk of thromboembolism. Previous studies had documented decreased thromboembolic events due to administering anticoagulants. Keyword: Acute Stroke, Dilated Cardiomyopathy, Limb Ischemia, Massive Intracardiac Thrombus.
LGPD: CONCEPTS, CHALLENGES AND AWARENESS IN THE NEW CULTURE FOR SOCIETY AND ORGANIZATIONS
Authors: Daniele Sucena Daniele Sucena
Published: July 2024

In recent decades, there has been exponential technological growth that has directly impacted the manipulation of data in society, making information a currency of great value, especially for public and private institutions, making data governance fundamental to mitigating possible risks. of personal data leakage. In this way, the General Data Protection Law (LGPD), emerged, based on European Legislation (GDPR), to assist in the responsible processing of sensitive data and its effective implementation has become crucial for organizations to meet legal obligations and protect citizens' personal data. This work aims to demonstrate to society that organizations need to adapt to the law, presenting strategies for its implementation, in order to guarantee more assertive and secure management of sensitive data. In view of this, research was carried out through bibliographic studies on the topic, highlighting the engagement of interested parties as the main factor for success.
Gerenciando pequenas propriedades rurais com o Plantae: aplicativo digital para microagricultores
Authors: Cardoso Arthur , Siqueira Vinícius O. , Gonçalves Eliezer D. , Escalfoni Rafael
Published: July 2024

Pequenas propriedades rurais desempenham um papel fundamental na produção de alimentos, representando cerca de 70% do mercado interno brasileiro. Embora possuam grande relevância no cenário nacional, os incentivos aos pequenos produtores são escassos, sendo poucas as iniciativas dedicadas ao aperfeiçoamento das práticas para este nicho produtivo. Objetivando auxiliar a operação destes trabalhadores, realizamos um estudo de caso com um grupo de produtores do município rural de Nova Friburgo que resultou no desenvolvimento de uma plataforma denominada "Plantae", voltada para pequenas propriedades rurais. O Plantae auxilia a gestão de plantações para o controle de produção, insumos e demais atividades relacionadas. A ferramenta foi desenvolvida de baseada em componentes podendo ser estendida de acordo com as novas demandas, sendo que o módulo de insumos foi testado através de uma prova de conceito em um dos sítios parceiros. Os resultados obtidos no estudo sugerem que a abordagem proposta facilitou a gestão de materiais utilizados em plantações.
Transformasi tanah perdikan sebagai basis pengembangan budaya Islam Jawa (analisa pada tanah perdikan Majan Tulungagung)
Authors: Awalin Fatkur Rohman Nur
Published: July 2024

Tanah perdikan sebagai tanah bebas pejak merupakan anugrah dari raja kepada rakyatnya. Pamor tanah perdikan saat ini meredup karena sudah dihapuskan melebur ke NKRI. Namun pada sisi lainnya kearifan-kearifan dalam tanah perdikan masih bisa diidentifikasi sampai saat ini. Sampelnya adalah tanah perdikan Majan Tulungagung Jawa Timur. Secara legal formal tanah perdikan Majan di berikan kepada KHR. Khasan Mimbar oleh Raja Mataram Islam Pakubuwana II tahun 1727 M. Pemberian tanah perdikan merupakan hak penuh KHR. Khasan Mimbar dalam mengelolanya untuk  mendakwahkan Islam di kabupaten Ngrowo sekarang bertransformasi menjadi kabupaten Tulungagung. Dalam pengelolaanya KHR. Khasan Mimbar mendirikan Masjdi Al-Mimbar dan Pondok Pesantren Nggrenjol. Berdasarkan analisanya ditemukan kearifan-kearifan seperti jamasan pusaka kyai golok, nikah Majan dan grebeg Maulud. Kesimpulannya berdasarkan kasu tanah perdikan Majan merupakan kuasa Kyai dalam hal ini dikembangkan untuk mendakwahkan agama Islam yang rahmatan lil alamin. Indikatornya adalah tidak bertentangan budaya setempat dimana Islam itu tumbuh. Sehingga wajah Islam penuh dengan kedamaian yang mampu mengadvokasi budaya masyarakat setempat.
Nilai sosial dalam geguritan Ki Patih Ganjira
Authors: Paramarta I Ketut
Published: July 2024

Abstrak Penelitian ini mendeskripsikan nilai sosial dalam geguritan Ki Patih Ganjira. Dalam penelitian menggunakan metode deskriptif kualitatif. Subjek penelitian adalah geguritan Ki Patih Ganjira. Objek penelitian adalah nilai sosial dalam geguritan Ki Patih Ganjira. Pengumpulan data menggunakan teknik baca, teknik catat dan studi dokumentasi. Instrumen pengumpulan data penelitian menggunakan kartu data. Tahapan analisis data mencakup memilih data, menjelaskan data, menyimpulkan, dan verifikasi data. Berdasarkan hasil analisis data, nilai sosial yang terdapat pada geguritan Ki Patih Ganjira adalah: (1) nilai sosial kasih sayang yang terdiri dari nilai sosial pengabdian, tolong menolong, keluwarga, kesetian, kepedulian, (2) nilai sosial tanggungjawab terdiri dari nilai sosial tanggungjawab pada keluarga, pada masyarakat, dan pada Tuhan Yang Maha Esa, dan (3) nilai sosial keserasian hidup yang terdiri dari nilai sosial keadilan, toleransi, dan demokrasi.Kata Kunci: Nilai Sosial, Karya Sastra, GeguritanAbstractThis study describes the social values in Ki Patih Ganjira's geguritan. In research using descriptive qualitative methods. The research subject was Ki Patih Ganjira's geguritan. The object of research is the social value in Ki Patih Ganjira's geguritan. Data collection uses reading techniques, note-taking techniques and documentation studies. Research data collection instruments using data cards. The stages of data analysis include selecting data, explaining data, concluding, and verifying data. Based on the results of data analysis, the social values contained in Ki Patih Ganjira's geguritan are (1) social values of affection consisting of social values of dedication, helping, family, loyalty, and caring, (2) social values of responsibility consisting of social values of responsibility to the family, to society, and to God Almighty, and (3) social values of harmony in life which consist of social values of justice, tolerance, and democracy.Keywords: Social values, literary works, geguritan
Delinquency behavior from Adverse Childhood Experience
Authors: Ernawati Linda
Published: July 2024

Delinquent behavior includes breaking the rules to committing criminal acts. There are many factors behind delinquency behavior, both internally and externally. Externally, this behavior cannot be separated from events that occurred in childhood, especially events experienced in the family environment or as an Adverse Childhood Experience (ACE). Of the 6 delinquency groups in the Child Correctional Institution, this study intends to see what ACEs are experienced by juvenile delinquency perpetrators. The research subjects were taken as a whole as many as 72 teenagers. Data collection using the Adverse Childhood Experience scale. Data analysis using ANOVA. The results show that there is no difference in Adverse Childhood Experience in the 6 delinquency groups. From the average obtained, the group for drug crimes, sexual crimes, murder, theft, and child protection experienced 5 types of Adverse Childhood Experience, and the brawling group experienced 4 types of Adverse Childhood Experience. The types of Adverse Childhood experiences that are often experienced by juvenile delinquents are emotional neglect and physical neglect. 68% of teenagers who carry out delinquent behavior come from families whose parents work as laborer and traders
How positive is their future? Assessing the role of social support and optimism in patients with cardiovascular disease
Authors: Putra Rahman Pranovri , Sudirman Subhan Ajrin , Fadhilah Fadhilah
Published: July 2024

Someone with coronary heart disease is someone who has a heart defect that makes the heart experience narrowing or inhibition of arteries that drain blood to the heart muscle. This situation may affect the optimism of life that exists in coronary heart patients. However, if coronary heart patients get social support from their partners, it can have a good impact on the level of life optimism. This study aims to determine whether there is a relationship between spousal social support and life optimism in coronary heart disease patients in Pekanbaru City, Riau. This study uses correlational quantitative research methods. The population in this study amounted to 213 people and the sample amounted to 139 people. The sample was determined using non-probability sampling technique. Then, the data were analyzed using Pearson Product Moment correlation analysis. The results of this study indicate that the level of Partner social support is in the high category and life optimism is in the moderate category. Then, the results of the correlation test between partner social support and life optimism obtained a p value = 0.044 and a correlation coefficient value of 0.141. This shows that the proposed research hypothesis is accepted, namely that there is a positive relationship between partner social support and life optimism in patients with cardiovascular disease.
Tweeting through troubles: Exploring the connection between self-disclosure on the autobase Twitter account and emotion-focused coping strategies
Authors: Nugroho Alnico Imam , Nurhayati Siti Rohmah
Published: July 2024

Social media Twitter, especially autobase @Jogjamnfs account should be used to inquire about things related to Yogyakarta. However, the followers of this account use it to do self-disclosure. In connection with that the sender cannot show his capability in managing this emotion that comes to the tweet that they send. Therefore, this research aims to find out the relations between self disclosure that is conducted through social media twitter on @Jogjamnfs account with senders' emotion focused coping. Participants of this research are 392 followers of @Jogjamnfs account. The method used in this research is a quantitative research method with correlational design. The sampling of this research used accidental sampling. The result of this research shows that there is a significant positive relationship between self disclosure and senders' emotion focused coping (p=0.000 and r=0.33). It means that if there is an increase of self disclosure than related to emotion focused coping increasing and vice versa. The followers of @Jogjamnfs account on average have self disclosure behavior at medium level with high emotion focused coping.
ADOPTION OF TECHNOLOGY FOR CONSTRUCTION SITE SAFETY MANAGEMENT: UNVEILING INSIGHT FROM PENANG CONTRACTORS
Authors: Ting Teoh Li , Yahaya Izyan
Published: July 2024

The construction industry has the highest fatality rate among other industries. In light of this, the pivotal role played by contractors in leveraging technology to enhance site safety cannot be ignored. Despite the emergence of various technologies, little is still known about the extent of their involvement in this regard. Thus, this research intends to explore technology adoption for safety practices among contractors, the influencing factors, and the challenges encountered when implementing this innovative approach. Survey questionnaires were distributed to G7 contractors in Penang, and 53 valid responses were obtained. The findings show that the current level of technology adoption for site safety management is still low. Key factors influencing technology adoption include the initial cost, top management commitment and contractors’ awareness of the technology. Contractors’ challenges involve high technology expenses, inadequate network connectivity and reduced industry profitability. This research augments the existing knowledge about technology adoption for site safety management. The outcomes further serve as useful information for contractors, policymakers and government agencies in developing initiatives to improve technology adoption among contractors and reduce the occurrence of accidents in Malaysia.
MODULAR CONSTRUCTION SYSTEMS: A FOCUS ON DEVELOPING TECHNICAL EXPERTISE IN MALAYSIA
Authors: Ismail Mohamad Zahierruden , Kamarudin Tantish , Abdul Halim Nur Hajarul Falahi
Published: July 2024

The Government has clearly put focus on MCS as the future of construction through the Construction 4.0 Strategic Plan (2021-2025) and National Construction Policy 2030. However, the implementation of MCS in Malaysia is still low due to lack of technical expertise. This study aims to explore the challenges and strategies in achieving sufficient technical expertise to drive construction players in adopting MCS. Exploratory interviews were conducted with MCS experts to obtain multiple views in enhancing technical expertise to implement MCS in construction business. Respondents were obtained through snowball sampling techniques by approaching expert personnel in MCS. Findings were then analysed using thematic analysis, discovering four main challenges that impede adoption of MCS and four aspects of strategies identified to enhance technical expertise in MCS. The exploratory nature of this study provides the preliminary indicators for future actions to drive the adoption of MCS in developing countries.
DEVELOPMENT OF PROCEDURAL FRAMEWORK FOR 6R IMPLEMENTATION IN CONSTRUCTION WASTE MANAGEMENT
Authors: Min Joshua Chua Shu , Thing Hong Wan , Jing Chai Yoon , Mahmud Abba Tahir , Mohd Fateh Mohd Ashraf
Published: July 2024

Sustainable construction has become a top priority in most developing countries including Malaysia. With the rapid development progress in Malaysia, construction waste continues to rise and putting pressure on the social, economy, and environmental sustainability of the nation. Effective construction waste management (CWM) is crucial for achieving the sustainability goals. A well-designed waste management strategy is essential to minimise the environmental impact of waste generation for a more resilient built environment. Past researchers have identified a lack of systematic procedures for CWM and implementation by contractors. This research aims to address this gap by developing a procedural framework for implementing the 6R approach - refuse, reduce, reuse, recycle, recovery, and reflect in the local construction waste management. An extensive literature review on the CWM practices was conducted followed by a preliminary focused-group interview with the Solid Waste Management and Public Cleansing Corporation (SWCorp). A draft procedural framework focusing on 6R waste management was developed following the pilot group studies. To improve the developed framework, semi-structured interviews with the main contractors were conducted for their insights on the current practices and challenges faced in construction waste management, and the feasibility of the proposed procedural framework. The interview findings showed great support to the developed procedural framework with little recommendations incorporated. A final procedural framework was then concluded for implementation. This study presents a significant opportunity for the main contractor in practising sustainable construction waste management (SCWM) through the recommended procedural model.