bluuebunny/crossref_metadata_2025 huggingface dataset:
Educational Consequences of Paternal Incarceration: Evidence from a Danish Policy Reform
Authors: Anker Anne Sofie Tegner
Published: September 2021

Objectives

This study estimates the causal effect of paternal incarceration on children’s educational outcomes measured at the end of compulsory schooling (9th grade) in Denmark.

Methods

I use Danish administrative data and rely on a sentencing reform in 2000, which expanded the use of non-custodial alternatives to incarceration for traffic offenders, for plausibly exogenous variation in the risk of experiencing paternal incarceration.

Results

The results show that paternal incarceration does not affect academic achievement (grade point average), but that it does reduce the number of grades obtained, and–most importantly–roughly doubles the risk of not even completing compulsory school and getting a 9th grade certificate. These findings are driven mainly by boys for whom paternal incarceration appear to be particularly consequential.

Conclusions

The findings presented in this study highlight the presence of unintended and collateral consequences of penal policies–even in the context of a relatively mild penal regime. Effects are, however, estimated for a subgroup of Danish children experiencing paternal incarceration, and how results translate to other subgroups and beyond the Danish context is open for speculation.
Numerical Modelling of Convection-Driven Cooling, Deformation and Fracturing of Thermo-Poroelastic Media
Authors: Stefansson Ivar , Keilegavlen Eirik , Halldórsdóttir Sæunn , Berre Inga
Published: September 2021

Convection-driven cooling in porous media influences thermo-poro-mechanical stresses, thereby causing deformation. These processes are strongly influenced by the presence of fractures, which dominate flow and heat transfer. At the same time, the fractures deform and propagate in response to changes in the stress state. Mathematically, the model governing the physics is tightly coupled and must account for the strong discontinuities introduced by the fractures. Over the last decade, and motivated by a number of porous media applications, research into such coupled models has advanced modelling of processes in porous media substantially. Building on this effort, this work presents a novel model that couples fracture flow and heat transfer and deformation and propagation of fractures with flow, heat transfer and thermo-poroelasticity in the matrix. The model is based on explicit representation of fractures in the porous medium and discretised using multi-point finite volume methods. Frictional contact and non-penetration conditions for the fractures are handled through active set methods, while a propagation criterion based on stress intensity factors governs fracture extension. Considering both forced and natural convection processes, numerical results show the intricate nature of thermo-poromechanical fracture deformation and propagation.
Clinical and Economic Impact of Previous Bariatric Surgery on Liver Transplantation: a Nationwide, Population-Based Retrospective Study
Authors: Iannelli Antonio , Bulsei Julie , Debs Tarek , Tran Albert , Lazzati Andrea , Gugenheim Jean , Anty Rodolphe , Petrucciani Niccolo , Fontas Eric
Published: September 2021

Purpose

The present study aims to determine the impact of previous bariatric surgery (BS) on the length of hospital stay; the incidence of mortality, re-transplantation, and re-hospitalization after LT; and the related economic costs, through the analysis of the French National Health Insurance Information System.

Materials and Methods

All patients aged > 18 years who underwent LT in France in the period from 2010 to 2019 were included. Thirty-nine patients with a history of BS (study group) were compared with 1798 obese patients without previous BS (control group).

Results

At the time of LT, patients with a history of BS were significantly younger than those of the control group and had lower Charlson comorbidity index. Female sex was significantly more represented in the study group. No significant differences were detected between the two groups regarding the postoperative mortality rate after LT (10.3% in the study group versus 8.0% in the control group), long-term mortality (0.038 versus 0.029 person-year of follow-up, respectively), re-transplantation (adjusted hazard ratio (HR) = 2.15, p = 0.2437), re-hospitalization (adjusted analysis, IRR = 0.93, p = 0.7517), and costs of LT hospitalization (73,515 € in the study group versus 65,878 € in the control group). After 1:2 propensity score matching, the duration of the LT hospital stay was significantly longer in the study group (58.3 versus 33.4 days, p = 0.0172).

Conclusion

No significant differences were detected between patients with previous BS versus obese patients without history of BS undergoing LT concerning the rates of mortality, re-LT, re-hospitalization after LT, and costs of hospitalization and re-hospitalizations.

Graphical abstract
The effect of consolidated periods in heterogeneous lot-sizing games
Authors: Guardiola Luis A. , Meca Ana , Puerto Justo
Published: September 2021

We consider a cooperative game defined by an economic lot-sizing problem with heterogeneous costs over a finite time horizon, in which each firm faces demand for a single product in each period and coalitions can pool orders. The model of cooperation works as follows: ordering channels and holding and backlogging technologies are shared among the members of the coalitions. This implies that each firm uses the best ordering channel and holding technology provided by the participants in the consortium. That is, they produce, hold inventory, pay backlogged demand and make orders at the minimum cost of the coalition members. Thus, firms aim at satisfying their demand over the planing horizon with minimal operation cost. Our contribution is to show that there exist fair allocations of the overall operation cost among the firms so that no group of agents profit from leaving the consortium. Then we propose a parametric family of cost allocations and provide sufficient conditions for this to be a stable family against coalitional defections of firms. Finally, we focus on those periods of the time horizon that are consolidated and we analyze their effect on the stability of cost allocations.
Thermophysical Properties of Mixtures of Thorium and Uranium Nitride
Authors: Parker S. S. , Newman S. , Fallgren A. J. , White J. T.
Published: September 2021

The miscibility, lattice parameter, and thermophysical properties of (Th0.2U0.8)N and (Th0.5U0.5)N have been investigated. It is shown that additions of thorium nitride (ThN) to uranium nitride (UN) increases the thermophysical performance of the mixed nitride fuel form in comparison to reference UN. In the more dilute limit, additions of ThN serve as a burnable neutronic poison and reduces the change in keff over the lifecycle of the fuel. At higher concentrations, additions of ThN serve as a significant fertile source of 233U. Where appropriate, comparisons to previous work on UN + PuN mixtures are made, as this is a comparable fuel form for potential fast reactor concepts, and a suitable point of contrast in the possible design space afforded by mixed (ThxU1 − x)N fuel forms. The data from this work are the input parameters for finite element modeling of the temperature distribution in a compact reactor. The results of modeling and simulation of this core design are shown for the case of steady-state operation and during double, adjacent heat pipe failure.
Parallel Metabolomic Profiling of Cerebrospinal Fluid, Plasma, and Spinal Cord to Identify Biomarkers for Spinal Cord Injury
Authors: Yang Hua , Zhang Pengwei , Xie Min , Luo Jianxian , Zhang Jing , Zhang Guowei , Wang Yang , Lin Hongsheng , Ji Zhisheng
Published: September 2021

Loss of physical and emotional health due to spinal cord injury (SCI) has been rapidly increasing worldwide. Effective evaluation of the severity of SCI is crucial to its prognosis. Herein, we constructed rat models of SCI with four different degrees of injury (sham group, light injury group, moderate injury group, and heavy injury group), using the surgical approach. Cerebrospinal fluid (CSF), plasma, and spinal cord were sampled at the sub-acute spinal cord (72 h post-injury) from each rat. The LC–MS-based metabolic profiling of these samples was performed according to a universal metabolome standard (UMS). The results demonstrated that 130, 104, and 128 metabolites were significantly altered within the CSF, plasma, and spinal cord samples, respectively. Among them, there were four differential metabolites, including uric acid, phosphorycholine, pyridoxine, and guanidoacetic acid, which were commonly identified within the CSF, plasma, and spinal cord samples. Further pathway analysis of these differential metabolites demonstrated a disturbance in the metabolism of glyoxylate and dicarboxylate and glycine, serine, and threonine which were associated with pathophysiologic consequence of spinal cord injury. In particular, phosphorycholine, pyridoxine, and guanidoacetic acid demonstrated a relationship with SCI severity. Thus, they could be utilized as potential metabolite biomarkers for SCI severity assessment.
Efficient treatment of esophageal nutrition bezoars: dissolution outmatches removal—the Zurich approach
Authors: Morell Bernhard , Buehler Philipp Karl , Bader Patrick Raphael , Lang Silvia , Scharl Michael , Gubler Christoph , Murray Fritz Ruprecht
Published: September 2021

Enteral feed bezoars are difficult to treat and can lead to serious adverse events. There is no standardized treatment approach and various strategies have been suggested. We herein describe three cases of successful dissolutions of feed bezoars consisting of Promote® Fibre Plus with sodium bicarbonate 8.4% in critically ill patients. To provide the rationale for this approach, the effect of sodium bicarbonate 8.4% on enteral feed concretions was studied in vitro. First, Promote® Fibres Plus was incubated with hydrochloric acid with gradually decreasing pH values to establish a pH at which the solution solidifies. The resulting enteral feed concretion was exposed to sodium bicarbonate 8.4% and Coca Cola®. All patients were successfully treated with sodium bicarbonate 8.4% without the need of lengthy or repeat endoscopies. In vitro, Promote® Fibres Plus solidifies when acidified below a pH of 4.6. The resulting enteral feed concretions dissolved when exposed to sodium bicarbonate 8.4%. Incubation with Coca Cola® had no effect. We provide evidence that enteral feed bezoars consisting of Promote® Fibres Plus can be efficiently and safely treated with sodium bicarbonate 8.4% offering a new approach for daily patient care.
Role of capillary adhesion in the friction peak during the tacky transition
Authors: Gao Tianyan , Ye Jiaxin , Zhang Kaisen , Liu Xiaojun , Zhang Yan , Liu Kun
Published: September 2021

The friction peak that occurs in tire-road sliding when the contact changes from wet to dry was previously attributed to capillary cohesion, van der Waals attraction, and surface roughness, but the detailed mechanisms have yet to be revealed. In this study, friction and static contact experiments were conducted using a custom-built in situ optical microtribometer, which allowed us to investigate the evolution of the friction, normal load, and contact area between a polydimethylsiloxane (PDMS) film and a silicon nitride ball during water volatilization. The friction coefficient increased by 100%, and the normal force dropped by 30% relative to those in the dry condition during the wet-to-dry transition. In static contact experiments, the probe indentation depth increased, and the normal load decreased by ∼60% as the water evaporated. Combining the friction and static contact results, we propose that the large friction peak that appeared in this study can be attributed to the combined effects of increased adhesive capillary force and increased plowing during the wet-to-dry transition.
Modeling of hot-point drilling in ice
Authors: Li Yazhou , Talalay Pavel G. , Fan Xiaopeng , Li Bing , Hong Jialin
Published: September 2021

Hot-point drills have been widely used for drilling boreholes in glaciers, ice caps and ice sheets. A hot-point drill melts ice through the thermal head at its bottom end. Penetration occurs through a close-contact melting (CCM) process, in which the ice is melted, and the meltwater is squeezed out by the exerted force applied on the thermal head. During the drilling, a thin water film is formed to separate the thermal head from the surrounding ice. For the hot-point drill, the rate of penetration (ROP) is influenced by several variables, such as thermal head shape, buoyancy corrected force (BCF), thermal head power (or temperature) and ice temperature. In this study, we developed a model to describe the CCM process, where a constant power or temperature on the working surface of a thermal head is assumed. The model was developed using COMSOL Multiphysics 5.3a software to evaluate the effects of different variables on the CCM process. It was discovered that the effect of thermal head shape and the cone angle of conical thermal head on ROP is less significant, whereas the increase in the BCF and the power (or temperature) of the thermal head can continuously enhance the ROP.
The Iron Hand of Power: US Architectural Imperialism in the Philippines
Authors: Immerwahr Daniel
Published: September 2021

Architects and urban planners in the United States at the turn of the twentieth century, particularly those working in the City Beautiful style, held lofty ambitions yet struggled to carry them out. In cities such as Washington DC and Chicago, political resistance made executing their plans onerous. In the US colonies, however, they operated with greater liberty. This article follows the spatial vision of Daniel Burnham (1846–1912) from the mainland US to the Philippines. In that colonial setting, Burnham was able to realise his vision far more easily, as neither he nor the officials executing his plans were ultimately accountable to Filipinos. Forced labour, confiscated land, repurposed public money, unchecked political power and wartime social disruption all aided US architectural imperialism. Rather than regretting this, Burnham and his associates celebrated the opportunities that their undemocratic setting provided. This article treats not only Burnham but also William E. Parsons (1872–1939) and Cameron Forbes (1870–1959), who extrapolated and enforced Burnham’s plans, and Juan Arellano (1888–1960), the Filipino architect who, to his later regret, helped remake Manila in the colonisers’ image.
COVID-19 Vaccine Hesitancy Among Medical Students: The Next COVID-19 Challenge in Wuhan, China
Authors: Gao Xudong , Li Haiyan , He Wenjie , Zeng Wen
Published: September 2021

Objective:

The purpose of this study was to explore the level of coronavirus disease 2019 (COVID-19) vaccine hesitancy among medical students in Wuhan, China, and to identify the factors and barriers associated with their vaccination decision.

Methods:

A cross-sectional survey was launched with 612 medical students recruited by convenience sampling from 6 universities. Data collection measures mainly included a demographic questionnaire, COVID-19 vaccine knowledge questionnaire, and the vaccine hesitancy scale.

Results:

A total of 58.2% of medical students reported vaccine hesitancy. The most common reasons for this were worrying about the side effects of vaccines (44.4%), uncertainty about vaccine safety (40.4%), and underestimating the risk of exposure to COVID-19 (27.9%). The main factors associated with COVID-19 vaccine hesitancy among participants were their knowledge about COVID-19 vaccine, training related to COVID-19 vaccines, family address, and education level (P < 0.05).

Conclusions:

The government, health department and universities in China need to work together and actively communicate with vaccine-hesitant students, establish a standardized COVID-19 vaccine course, and provide on-campus vaccination services.
A computerized indicator for surgical site infection (SSI) assessment after total hip or total knee replacement: The French ISO-ORTHO indicator
Authors: Grammatico-Guillon Leslie , Miliani Katiuska , Banaei-Bouchareb Linda , Solomiac Agnès , Sambour Jessica , May-Michelangeli Laetitia , Astagneau Pascal
Published: September 2021

Objective:

The French National Authority for Health (HAS), with a multidisciplinary working group, developed an indicator ‘ISO-ORTHO’ to assess surgical site infections (SSIs) after total hip arthroplasty or total knee arthroplasty (THA/TKA) based on the hospital discharge database. We present the ISO-ORTHO indicator designed for SSI automated detection and its relevance for quality improvement and hospital benchmarks.

Methods:

The algorithm is based on a combination of International Statistical Classification of Diseases, Tenth Revision (ICD-10) and procedure codes of the hospital stay. The target population was selected among adult patients who had a THA or TKA between January 1, 2017, and September 30, 2017. Patients at very high risk of SSI and/or with SSI not related to hospital care were excluded. We searched databases for SSIs up to 3 months after THA/TKA. The standardized infection ratio (SIR) of observed versus expected SSIs was calculated (logistic regression) and displayed as funnel plot with 2 and 3 standard deviations (SD) after adjustment for 13 factors known to increase SSI risk.

Results:

In total, 790 hospitals and 139,926 THA/TKA stays were assessed; 1,253 SSI were detected in the 473 included hospitals (incidence, 0.9%: 1.0% for THA, 0.80% for TKA). The SSI rate was significantly higher in males (1.2%), in patients with previous osteo-articular infection (4.4%), and those with cancer (2.3%), obesity, or diabetes. Most hospitals (89.9%) were within 2 SD; however, 12 hospitals were classified as outliers at more than +3 SD (1.6% of facilities), and 59 hospitals (7.9%) were outliers between +2 SD and +3 SD.

Conclusion:

ISO-ORTHO is a relevant indicator for automated surveillance; it can provide hospitals a metric for SSI assessment that may contribute to improving patient outcomes.
Total water intake and its contributors in infants and young children
Authors: Chouraqui Jean-Pierre , Thornton Simon N. , Seconda Louise , Kavouras Stavros A.
Published: September 2021

Hydration is a particular concern for infants and young children due to their greater risk of dehydration. However, studies on their water intakes are scarce. The current survey aimed to analyse total water intake (TWI) in non-breastfed children aged 0·5–35 months compared with the adequate intake (AI) for the same age group set by the European Food Safety Authority and to examine the different contributors to TWI as well as beverage consumption patterns. Nationally representative data from the Nutri-Bébé cross-sectional survey were used to assess food, beverage and plain water consumption by age group over three non-consecutive days. With age, median TWI in 1035 children increased from 732 to 1010 ml/d, without differences between sexes, but with a great inter-individual variation, and the percentage of children who did not meet the AI increased from 10 to 88 %. Median weight-related TWI decreased from 136·6 to 69·0 ml/kg per d. Among infants, 90 % had a ratio of water:energy below the AI, similarly for about 75 % of toddlers. Milk and milk products were the main contributors to TWI, while the part of plain water increased gradually to be 25 % in the older toddlers, half of which was tap water. The beverage consumption pattern varied in types and timing, with little consumption of juices and sweetened beverages. Vegetables and fruits accounted for 20 % of TWI after the age of 6 months. These initial results, showing strong discrepancies between actual and recommended water intakes in young children, should help identify ways to increase children’s water consumption.
DIVINE CONFIRMATION: PLATO, TIMAEUS 55C7–D6
Authors: Petrucci Federico M.
Published: September 2021

Burnet's text at Pl. Ti. 55c7–d6 is at least questionable, and opting for a different reading at 55d5 (θεός instead of θεόν) would shed light on an intriguing argumentative aspect of Plato's cosmological account: God confirms the metaphysical reasons why there is just one perfect world.
Olfactory dysfunction and coronavirus disease 2019 severity: a prospective cohort study
Authors: Aydemir L , Sen C , Kara H , Demir A A , Bozbora E , Uysal E , Kesimli C , Orhan K S , Comoglu S , Keles Turel M N
Published: September 2021

Objective

The primary goal of this study was to evaluate the association between olfactory dysfunction or taste impairment and disease severity and radiological findings in coronavirus disease-2019. The secondary goal was to assess the prevalence, severity and course of olfactory dysfunction or taste impairment in patients with coronavirus disease 2019.

Method

This prospective observational cohort study evaluated patients hospitalised with coronavirus disease 2019 between April 1 and 1 May 2020. Olfactory dysfunction and taste impairment were evaluated by two questionnaires. Chest computed tomography findings and coronavirus disease-2019 severity were assessed.

Results

Among 133 patients, 23.3 per cent and 30.8 per cent experienced olfactory dysfunction and taste impairment, respectively, and 17.2 per cent experienced both. The mean age was 56.03 years, and 64.7 per cent were male and 35.3 per cent were female. No statistically significant association was found between olfactory dysfunction (p = 0.706) and taste impairment (p = 0.35) with either disease severity or chest computed tomography grading.

Conclusion

Olfactory dysfunction or taste impairment does not have prognostic importance in patients with coronavirus disease 2019.
Fruit traits of tree species in lower montane rainforest at Doi Suthep–Pui, northern Thailand
Authors: Rueangket Apisada , Duengkae Prateep , Thinkampheang Sathid , Enright Neal J. , Marod Dokrak
Published: September 2021

Fruits are a major food resource for wildlifes and have evolved different traits which attract specific frugivores and facilitate seed dispersal. This study examines the quantity of the frequency of fruit tree species, distribution amongst fruit traits and estimates the potential availability of the fruit resource for frugivores in a 16-ha permanent forest plot at Doi Suthep–Pui, Thailand. The similarity amongst traits for fleshy fruited species was explored using Principal Component Analysis (PCA). Fleshy fruited species comprised 122 of 208 tree species >2 cm diameter at breast height (DBH) recorded in the permanent plot. Amongst fleshy fruited species, small fruits (length <20 mm) were most common (63.16% of species) while large fruits were rare (4.1%). Black was the most common fruit colour (43.4%). Principal Component Analysis of fruit traits explained 57% of total variance on the first three axes, and allowed identification of three species groups. Litsea martabanica and Persea gamblei are the greatest density and represented the major PCA group; black, small-sized and thin husk indehiscent fruits. These fruiting trees scattered throughout the permanent plot and were of good regeneration status. Indicating fleshy fruit can be a food resource for frugivores especially small-sized fruit. Furthermore, large-fruited species such as Madhuca floribunda is low density but important to preserve for food resource of large frugivores. This finding is very important not only for forest protection policy but also for wildlife conservation as food resources.
Surface Core Hole Electron Energy-Loss Fine Structure in MgO: Experiment and Theory
Authors: Mendis BG
Published: September 2021

Core holes are an important contributing factor to the core-loss fine structure in electron energy-loss spectroscopy (EELS). While there has been much work on bulk materials, less is known about core hole screening in more complex dielectric environments, such as free surfaces or interfaces between two different materials, even though the latter is frequently encountered in high spatial resolution EELS analysis. In this work, experimental O K- and Mg L3,2-EELS edges from the free surfaces of a MgO cube are measured using scanning transmission electron microscopy (STEM). The free surface O K-spectrum shows extra intensity at the edge onset compared with the “bulk” spectrum. Core hole screening near a free surface is modeled using electrodynamic theory. It is shown that much of the extra intensity is due to reduced core hole screening, while genuine surface states make a smaller contribution to the fine structure. The low energy Mg L3,2-edge, however, does not show any significant change at a free surface. This is because the measurement is less surface sensitive due to strong delocalization.
Attending to the Ignored
Authors: Williams Kipling D. , Eckhardt Christopher I. , Maloney Molly A.
Published: September 2021

Abstract. Ostracism – being excluded and ignored – has received considerable attention in social psychology in the past few decades. Experimental evidence suggests that negative psychological reactions to ostracism are robust and widespread. Initially, ostracism is detected quickly as painful and reduces the satisfaction of four fundamental needs: belonging, self-esteem, control, and meaningful existence. When ostracism is experienced occasionally, individuals tend to respond and cope by trying to fortify the threatened needs, either by attempting to improve their inclusionary status (fortifying belonging and self-esteem by being more likable, agreeable, and pliable), by exerting more control and attention (by becoming more provocative, noticeable, but also sometimes more aggressive and violent), or by reducing future episodes of ostracism by seeking solitude. Persistent or long-term exposure to ostracism results in decreased coping attempts, and higher rates of alienation, depression, learned helplessness, and unworthiness. In this article, we integrate these findings with clinical theory and practice, seeking to apply experimental results to therapeutic applications.
Rejection Sensitivity in Intimate Relationships
Authors: Richter Marianne , Schoebi Dominik
Published: September 2021

Abstract. The goal of the study was to investigate whether and how perceptions of rejection are predictive of perceptions of the partner’s responsiveness, and the intimacy felt with a romantic partner, daily. Moreover, we examined whether people who are more anxious and sensitive to rejection perceived more rejection in daily life and whether this foreshadowed perception of the partner to be less responsive. Analyses of daily data from a sample of 75 couples ( N = 150) who reported on their daily relational experiences suggest that rejection sensitivity and rejection experiences play a significant role in couples’ felt intimacy in daily life, and specifically for perceptions of responsiveness. Results also indicate that for women, rejection sensitivity is associated with more rejection experiences. We discuss the current results from a clinical and from a social psychological perspective, and we highlight how anxious apprehension and experience of rejection, and its interpersonal consequences, can be further considered in clinical practice.
Cures That (Make You) Work
Authors: Aengenheister Jana S. , Urban Renée , Halbeisen Georg
Published: September 2021

Abstract. Successful treatment not only depends on adhering to taking medication and attending therapy but also on behavioral changes. In two experiments (total N = 256), we investigated the hypothesis that the perceived social role of a treatment as partner (co-producer of a health-benefits) or servant (sole provider of health benefits) could promote or prevent intentions to engage in health-related behaviors. Specifically, we used headache treatment as an everyday example and found that participants were more inclined to engage in headache-reducing behaviors when painkillers were described as partners as compared to servants. Implications of these findings for the importance of anthropomorphic social perception in the clinical application are discussed.
Assessing Adaptive Irrigation Impacts on Water Scarcity in Nonstationary Environments—A Multi‐Agent Reinforcement Learning Approach
Authors: Hung Fengwei , Yang Y. C. Ethan
Published: September 2021

One major challenge in water resource management is to balance the uncertain and nonstationary water demands and supplies caused by the changing anthropogenic and hydroclimate conditions. To address this issue, we developed a reinforcement learning agent‐based modeling (RL‐ABM) framework where agents (agriculture water users) are able to learn and adjust water demands based on their interactions with the water systems. The intelligent agents are created by a reinforcement learning algorithm adapted from the Q‐learning algorithm. We illustrated this framework in a case study where the RL‐ABM is two‐way coupled with the Colorado River Simulation System (CRSS), a long‐term planning model used for the administration of the Colorado River Basin, for assessing agriculture water uses impacts on water scarcity. Seventy‐eight intelligent agents are simulated, which can be grouped into three categories based on their parameter values: the “aggressive” (swift actions; low regrets), the “forward‐looking conservative” (mild actions; high regrets; fast learning), and the “myopic conservative” (mild actions; median regrets; slow learning). The ABM‐CRSS results showed that the major reservoirs in the Upper Colorado Basin might experience more frequent water shortages due to the increasing water uses compared to the original CRSS results. If the drought continues, the case study also demonstrates that agents can learn and adjust their demands.
Glacier Structures: History Written in the Ice
Authors: Jennings Stephen , Hambrey Michael
Published: September 2021

As Earth’s climate heats up, glacier structures are being revealed in unprecedented detail, allowing glaciologists to understand how the behavior of glaciers has changed over centuries to millennia.
Australian Plate Subduction is Responsible for Northward Motion of the India‐Asia Collision Zone and ∼1,000 km Lateral Migration of the Indian Slab
Authors: Parsons Andrew J. , Sigloch Karin , Hosseini Kasra
Published: September 2021

Distributions of slabs within Earth's mantle are increasingly used to reconstruct past subduction zones, based on first‐order assumptions that slabs sink vertically after slab break‐off, and thus delineate paleo‐trench locations. Non‐vertical slab motions, which occur prior to break‐off, represent a potentially significant source of error for slab‐based plate reconstructions, but are poorly understood. We constrain lateral migration of the Indian slab and overlying India‐Asia collision zone by comparing tomographically imaged mantle structure with plate‐kinematic constraints. Following coupling of the Indian and Australian plates at the onset of collision, ∼1,000 km lateral migration of the Indian slab was driven by vertical subduction of the Australian slab. The sinking behaviors of individual slabs do not evolve in isolation, but instead influence, or are influenced by, other slabs in the same plate network. Hence, lateral slab migrations may be determined by interpreting the sinking behavior of slabs collectively, and with respect to plate kinematics.
Adjoint‐Based Inversion of Geodetic Data for Sources of Deformation and Strain
Authors: Smith J. Torquil , Vasco D. W.
Published: September 2021

An adjoint‐based formulation leads to a particularly efficient approach for inverting geodetic measurements for the source of the deformation. Specifically, the quantities necessary to iteratively improve the fit to the observations can be computed with just three forward calculations, one to obtain the current residuals, another to solve the adjoint problem, and a third to compute the step length. An inversion algorithm utilizing the adjoint‐based gradient is applied to a set of Interferometric Synthetic Aperture Radar (InSAR) data gathered between 2016 and 2018 over the Tulare Basin in California's Central Valley. Because the measured deformation is due to groundwater withdrawal, a penalty function is included in the inversion to avoid placing aquifer volume change in locations that are far from any documented wells. The solution of the inverse problem provides estimates of aquifer compaction that provide a match to the observed range changes while honoring the well data. The solution indicates an average aquifer volume loss of 2.17 /year over the two year period from January 2016 to January 2018, encompassing one drought year (2016) and one wet year (2017). This magnitude of lost volume is compatible with the 3.1 /year decrease in water volume for the entire Central Valley, estimated from GRACE satellite gravity data.
Electrostatic Conditions That Produce Fast Breakdown in Thunderstorms
Authors: Attanasio Alex , da Silva Caitano , Krehbiel Paul
Published: September 2021

Fast breakdown (FB), a breakdown process composed of systems of high‐velocity streamers, has been observed to precede lightning leader formation and play a critical role in lightning initiation. Vigorous FB events are responsible for the most powerful natural radio emissions on Earth, known as narrow bipolar events (NBEs). In this paper, an improved version of the Griffiths and Phelps (1976, https://doi.org/10.1029/jc081i021p03671) model of streamer breakdown is used alongside supervised machine learning techniques to probe the required electric fields and potentials inside thunderstorms to produce FB and NBEs. Our results show that the electrostatic conditions needed to produce FB observed in New Mexico at 9 km altitude and FB in Florida at 14 km altitude are about the same, each requiring about 100 MV potential difference to propagate 500 m. Additionally, the model illustrates how electric field enhancement ahead of propagating FB can initiate rebounding FB of the opposite polarity.
The self-assembled nanoparticle-based trimeric RBD mRNA vaccine elicits robust and durable protective immunity against SARS-CoV-2 in mice
Authors: Sun Wenqiang , He Lihong , Zhang He , Tian Xiaodong , Bai Zhihua , Sun Lei , Yang Limin , Jia Xiaojuan , Bi Yuhai , Luo Tingrong , Cheng Gong , Fan Wenhui , Liu Wenjun , Li Jing
Published: September 2021

As COVID-19 continues to spread rapidly worldwide and variants continue to emerge, the development and deployment of safe and effective vaccines are urgently needed. Here, we developed an mRNA vaccine based on the trimeric receptor-binding domain (RBD) of the SARS-CoV-2 spike (S) protein fused to ferritin-formed nanoparticles (TF-RBD). Compared to the trimeric form of the RBD mRNA vaccine (T-RBD), TF-RBD delivered intramuscularly elicited robust and durable humoral immunity as well as a Th1-biased cellular response. After further challenge with live SARS-CoV-2, immunization with a two-shot low-dose regimen of TF-RBD provided adequate protection in hACE2-transduced mice. In addition, the mRNA template of TF-RBD was easily and quickly engineered into a variant vaccine to address SARS-CoV-2 mutations. The TF-RBD multivalent vaccine produced broad-spectrum neutralizing antibodies against Alpha (B.1.1.7) and Beta (B.1.351) variants. This mRNA vaccine based on the encoded self-assembled nanoparticle-based trimer RBD provides a reference for the design of mRNA vaccines targeting SARS-CoV-2.
Sterol and lipid analyses identifies hypolipidemia and apolipoprotein disorders in autism associated with adaptive functioning deficits
Authors: Tierney Elaine , Remaley Alan T. , Thurm Audrey , Jager Leah R. , Wassif Christopher A. , Kratz Lisa E. , Bailey-Wilson Joan E. , Bukelis Irena , Sarphare Geeta , Jung Eun Sol , Brand Boudewien , Noah Kelly K. , Porter Forbes D.
Published: September 2021

An improved understanding of sterol and lipid abnormalities in individuals with autism spectrum disorder (ASD) could lead to personalized treatment approaches. Toward this end, in blood, we identified reduced synthesis of cholesterol in families with ≥2 children with ASD participating with the Autism Genetic Resource Exchange (AGRE), as well as reduced amounts of high-density lipoprotein cholesterol (HDL), apolipoprotein A1 (ApoA1) and apolipoprotein B (ApoB), with 19.9% of the subjects presenting with apolipoprotein patterns similar to hypolipidemic clinical syndromes and 30% with either or both ApoA1 and ApoB less than the fifth centile. Subjects with levels less than the fifth centile of HDL or ApoA1 or ApoA1 + ApoB had lower adaptive functioning than other individuals with ASD, and hypocholesterolemic subjects had apolipoprotein deficits significantly divergent from either typically developing individuals participating in National Institutes of Health or the National Health and Nutrition Examination Survey III.
High harmonic generation in two-dimensional Mott insulators
Authors: Orthodoxou Christopher , Zaïr Amelle , Booth George H.
Published: September 2021

With a combination of numerical methods, including quantum Monte Carlo, exact diagonalization, and a simplified dynamical mean-field model, we consider the attosecond charge dynamics of electrons induced by strong-field laser pulses in two-dimensional Mott insulators. The necessity to go beyond single-particle approaches in these strongly correlated systems has made the simulation of two-dimensional extended materials challenging, and we contrast their resulting high-harmonic emission with more widely studied one-dimensional analogues. As well as considering the photo-induced breakdown of the Mott insulating state and magnetic order, we also resolve the time and ultra-high-frequency domains of emission, which are used to characterize both the photo-transition, and the sub-cycle structure of the electron dynamics. This extends simulation capabilities and understanding of the photo-melting of these Mott insulators in two dimensions, at the frontier of attosecond non-equilibrium science of correlated materials.
Oral intake of rice overexpressing ubiquitin ligase inhibitory pentapeptide prevents atrophy in denervated skeletal muscle
Authors: Nakao Reiko , Shen Weilin , Shimajiri Yasuka , Kainou Kumiko , Sato Yuki , Ulla Anayt , Ohnishi Kohta , Ninomiya Miyuki , Ohno Ayako , Uchida Takayuki , Tanaka Mitsuru , Akama Kazuhito , Matsui Toshiro , Nikawa Takeshi
Published: September 2021

We previously reported that intramuscular injections of ubiquitin ligase CBLB inhibitory pentapeptide (Cblin; Asp-Gly-pTyr-Met-Pro) restored lost muscle mass caused by sciatic denervation. Here, we detected Cblin on the basolateral side of Caco-2 cells after being placed on the apical side, and found that cytochalasin D, a tight junction opener, enhanced Cblin transport. Orally administered Cblin was found in rat plasma, indicating that intact Cblin was absorbed in vitro and in vivo. Furthermore, transgenic Cblin peptide-enriched rice (CbR) prevented the denervation-induced loss of muscle mass and the upregulation of muscle atrophy-related ubiquitin ligases in mice. These findings indicated that CbR could serve as an alternative treatment for muscle atrophy.
Chemogenetic modulation of histaminergic neurons in the tuberomamillary nucleus alters territorial aggression and wakefulness
Authors: Naganuma Fumito , Nakamura Tadaho , Kuroyanagi Hiroshi , Tanaka Masato , Yoshikawa Takeo , Yanai Kazuhiko , Okamura Nobuyuki
Published: September 2021

Designer receptor activated by designer drugs (DREADDs) techniques are widely used to modulate the activities of specific neuronal populations during behavioural tasks. However, DREADDs-induced modulation of histaminergic neurons in the tuberomamillary nucleus (HATMN neurons) has produced inconsistent effects on the sleep–wake cycle, possibly due to the use of Hdc-Cre mice driving Cre recombinase and DREADDs activity outside the targeted region. Moreover, previous DREADDs studies have not examined locomotor activity and aggressive behaviours, which are also regulated by brain histamine levels. In the present study, we investigated the effects of HATMN activation and inhibition on the locomotor activity, aggressive behaviours and sleep–wake cycle of Hdc-Cre mice with minimal non-target expression of Cre-recombinase. Chemoactivation of HATMN moderately enhanced locomotor activity in a novel open field. Activation of HATMN neurons significantly enhanced aggressive behaviour in the resident–intruder test. Wakefulness was increased and non-rapid eye movement (NREM) sleep decreased for an hour by HATMN chemoactivation. Conversely HATMN chemoinhibition decreased wakefulness and increased NREM sleep for 6 h. These changes in wakefulness induced by HATMN modulation were related to the maintenance of vigilance state. These results indicate the influences of HATMN neurons on exploratory activity, territorial aggression, and wake maintenance.
Automatic detection and monitoring of abnormal skull shape in children with deformational plagiocephaly using deep learning
Authors: Tabatabaei Seyed Amir Hossein , Fischer Patrick , Wattendorf Sonja , Sabouripour Fatemeh , Howaldt Hans-Peter , Wilbrand Martina , Wilbrand Jan-Falco , Sohrabi Keywan
Published: September 2021

Craniofacial anomaly including deformational plagiocephaly as a result of deformities in head and facial bones evolution is a serious health problem in newbies. The impact of such condition on the affected infants is profound from both medical and social viewpoint. Indeed, timely diagnosing through different medical examinations like anthropometric measurements of the skull or even Computer Tomography (CT) image modality followed by a periodical screening and monitoring plays a vital role in treatment phase. In this paper, a classification model for detecting and monitoring deformational plagiocephaly in affected infants is presented. The presented model is based on a deep learning network architecture. The given model achieves high accuracy of 99.01% with other classification parameters. The input to the model are the images captured by commonly used smartphone cameras which waives the requirement to sophisticated medical imaging modalities. The method is deployed into a mobile application which enables the parents/caregivers and non-clinical experts to monitor and report the treatment progress at home.
Hemicentin-1 is an essential extracellular matrix component of the dermal–epidermal and myotendinous junctions
Authors: Welcker Daniela , Stein Cornelia , Feitosa Natalia Martins , Armistead Joy , Zhang Jin-Li , Lütke Steffen , Kleinridders Andre , Brüning Jens C. , Eming Sabine A. , Sengle Gerhard , Niehoff Anja , Bloch Wilhelm , Hammerschmidt Matthias
Published: September 2021

The extracellular matrix architecture is composed of supramolecular fibrillar networks that define tissue specific cellular microenvironments. Hemicentins (Hmcn1 and Hmcn2) are ancient and very large members (> 600 kDa) of the fibulin family, whose short members are known to guide proper morphology and functional behavior of specialized cell types predominantly in elastic tissues. However, the tissue distribution and function of Hemicentins within the cellular microenvironment of connective tissues has remained largely unknown. Performing in situ hybridization and immunofluorescence analyses, we found that mouse Hmcn1 and Hmcn2 show a complementary distribution throughout different tissues and developmental stages. In postnatal dermal–epidermal junctions (DEJ) and myotendinous junctions (MTJ), Hmcn1 is primarily produced by mesenchymal cells (fibroblasts, tenocytes), Hmcn2 by cells of epithelial origin (keratinocytes, myocytes). Hmcn1−/− mice are viable and show no overt phenotypes in tissue tensile strength and locomotion tests. However, transmission electron microscopy revealed ultrastructural basement membrane (BM) alterations at the DEJ and MTJ of Hmcn1−/− mice, pointing to a thus far unknown role of Hmcn1 for BM and connective tissue boundary integrity.
Spacetime in the brain: rapid brain network reorganization in visual processing and recovery
Authors: Wu Zheng , Sabel Bernhard A.
Published: September 2021

Functional connectivity networks (FCN) are the physiological basis of brain synchronization to integrating neural activity. They are not rigid but can reorganize under pathological conditions or during mental or behavioral states. However, because mental acts can be very fast, like the blink of an eye, we now used the visual system as a model to explore rapid FCN reorganization and its functional impact in normal, abnormal and post treatment vision. EEG-recordings were time-locked to visual stimulus presentation; graph analysis of neurophysiological oscillations were used to characterize millisecond FCN dynamics in healthy subjects and in patients with optic nerve damage before and after neuromodulation with alternating currents stimulation and were correlated with visual performance. We showed that rapid and transient FCN synchronization patterns in humans can evolve and dissolve in millisecond speed during visual processing. This rapid FCN reorganization is functionally relevant because disruption and recovery after treatment in optic nerve patients correlated with impaired and recovered visual performance, respectively. Because FCN hub and node interactions can evolve and dissolve in millisecond speed to manage spatial and temporal neural synchronization during visual processing and recovery, we propose “Brain Spacetime” as a fundamental principle of the human mind not only in visual cognition but also in vision restoration.
Wood ants as biological control of the forest pest beetles Ips spp.
Authors: Trigos-Peral Gema , Juhász Orsolya , Kiss Péter János , Módra Gábor , Tenyér Anna , Maák István
Published: September 2021

Climate change is one of the major threats to biodiversity, but its impact varies among the species. Bark beetles (Ipsspp.), as well as other wood-boring pests of European forests, show escalating numbers in response to the changes driven by climate change and seriously affect the survival of the forests through the massive killing of trees. Many methods were developed to control these wood-boring beetles, however, their implementation can be detrimental for other forest specialists. Ants are widely used for biological pest-control, so in our study, we aimed to test the effect ofFormica polyctenaon the control of the wood-boring beetles. The results show that the proportion of infested trees is significantly reduced by the increase of the number ofF. polyctenanests, with a strong effect on those infested by Ipsspecies. We also show that the boring beetle community is shaped by different biotic and abiotic factors, including the presence ofF. polyctenanests. However, the boring beetle infestation was not related to the latitude, altitude and age of the forests. Based on our results, we assert the effectiveness of the red wood ants as biological pest control and the importance of their conservation to keep the health of the forests.