bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical and pathophysiological aspects of impaired water and sodium metabolism in newborns and neurological complication
Authors: Tarasova Z. G. , Kirilochev O. K. , Sagitova G. R. , Cherkasov N. S.
Published: March 2023

This literature review covers the pathophysiological features of water and sodium exchange in newborns. The main mechanisms regulating fluid and electrolyte balance in newborns are poorly studied. The volume and composition of the extracellular fluid are provided by the functional activity of the kidneys under the control of the neuroendocrine system. The antidiuretic hormone plays the main role in the regulation of water excretion by the kidneys. The volume of intracellular fluid depends on the passive water transport with the participation of aquaporins. Lability of water and electrolyte metabolism in newborns may be accompanied by hyponatremia. For various pathological conditions in the neonatal period, certain types of hyponatremias are characteristic. Correction of hyponatremia should be carried out taking into account its pathophysiological type. Hyponatremia is a common complication associated with severe neonatal brain damage. Hyponatremia contributes to brain damage as an independent factor. The study of indicators of water and electrolyte balance in the neonatal period has an important prognostic value for early detection of damage to the central nervous system.
Long-term effects of antitumor therapy in nephrology practice: case series
Authors: Aksenova M. E. , Morozov S. L. , Shumikhina M. V.
Published: March 2023

The survival rate among children with cancer was significantly improved in recent years. About 40% of these patients, however, suffer from late complications of anticancer treatment. Risk factors of late kidney impairment include beginning of specific treatment before the age of 5 years; pre-existing kidney pathology; high cumulative dose of chemotherapy agents and radiation; surgery, including neurotomy. It is currently impossible to predict individual long-term effects of therapy. For this reason, the International Cancer Group suggests that all children who have undergone specific antitumor therapy be included in the risk group for the development of longterm complications, and to follow up asymptomatic patients surviving cancer without kidney function and structure impairment with at least yearly monitoring of blood pressure, blood count, urinalysis, serum creatinine, urea, K, Na, Ca, P, Mg, alkaline phosphatase. We described the spectrum of kidney diseases including ureterohydronephrosis, renovascular hypertension, Fanconi syndrome, and postradiation nephrosclerosis manifested from 8 months to 8 years after specific antitumor treatment.
Clinical and genetic spectrum of primary ciliary dyskinesia in children
Authors: Novak A. A. , Mizernitskiy Yu. L.
Published: March 2023

Primary ciliary dyskinesia is a rare genetically determined pathology that leads to chronic inflammatory damage to the respiratory tract, hearing organs and impaired fertility. This article presents the preliminary results of a study conducted in the clinic aimed at the possibility of predicting the clinical course of the disease depending on the genetic variants of the disease, which enables, with timely diagnosis, personalizing the approach to the treatment of children with such a disabling disease as primary ciliary dyskinesia.Purpose. To determine the clinical and genetic variants of primary ciliary dyskinesia, and to identify patterns of disease development. Material and methods. The study included children from 0 to 18 years old with a verified defect of the ciliary apparatus, by analyzing the mobility of the cilia of the ciliary epithelium of the mucous membrane of the respiratory tract, and who underwent a next generation sequencing exome study.Results. The study revealed characteristic patterns of target organ damage, prevailing in a group of children with impaired cilia assembly factor, as well as in a group of children with damaged dynein arms.Conclusion. Thus, conducting a genetic examination in children with suspected primary ciliary dyskinesia is relevant not only to confirm the disease, but also to predict the course of the disease.
Congenital pulmonary tuberculosis
Authors: Dolgopolov I. S. , Federiakina O. B. , Volzhenina O. M. , Erokhina G. G. , Leonov K. A. , Shneivais A. O. , Siadrin M. G. , Rykov M. Yu.
Published: March 2023

Congenital tuberculosis is a fatal disease in the absence of treatment. The diagnosis is difficult due to polymorphic and nonspecific symptoms in neonates, as well as the lack of alertness of neonatologists and pediatricians. Less than 500 confirmed cases of congenital tuberculosis have been described in the available literature. Mortality ranges from 15 to 33%. Early diagnosis and adequate therapy are essential to improve the prognosis of the disease. Two cases of pulmonary congenital tuberculosis in premature neonates with a positive maternal and familial history of tuberculosis is presented. The clinical symptoms and radiological features started on the days 24 and 48 of life, respectively. Shortness of breath, low blood oxygen level requiring oxygen therapy, fever, and impaired general well-being revealed. The chest X-ray revealed bilateral polysegmental infiltrative lesions with the formation of a cavity of destruction in one case. The diagnosis was established after the detection of M. tuberculosis DNA in gastric aspirates. Patients received therapy according to a regimen designed for multidrug-resistant tuberculosis, including conventional anti-TB drugs in combination with linezolid, fluoroquinolones, meropenem, and aminoglycosides. The infectious syndrome in a premature newborn associated with pneumonia resistant to standard antibiotic therapy, the presence of tuberculosis in the mother, relatives, or siblings require a work-up for the detection of M. tuberculosis and instrumental diagnostics. Early diagnosis and treatment are critical for improving the prognosis of the disease.
Russia’s invasion of Ukraine: The reaction of Islamic stocks in the energy sector of Indonesia
Authors: Rizqi Febriandika Nur , Mila Wati Rima , Hasanah Mauizhotul
Published: March 2023

The volatility of rising oil prices has certainly made the market more out of control. Market participants are very sensitive to various information and to global issues such as Russia’s invasion of Ukraine. This study aims to review the reaction of the Indonesian Islamic stock market in the energy sector before and after Russia’s invasion of Ukraine. The variables used are stock returns, abnormal returns, and trading volume activity. The sample of this study is represented by Indonesian sharia stocks in the energy sector using a purposive sampling method. The research period was from February 4, 2022 to March 18, 2022. The research method used was the Event Study Method (ESM) and paired sample different tests with the Microsoft Excel program and SPSS version 26. The results of the study show that there is a significant difference in the average stock returns in the periods of 3, 7, and 14 days before and after Russia’s invasion of Ukraine. There are also differences in abnormal returns for the 3-day and 14-day observation periods, while for the 7-day observation period, there are no significant differences in abnormal returns. Besides, there is an average difference in volume activity during the periods of 3 days, 7 days, and 14 days before and after the Russian invasion of Ukraine. Indirectly, this information about Russia’s invasion of Ukraine affected the performance of the capital market. This also shows that the semi-strong form of the efficient market hypothesis is proven in this study.
PHYTOCHEMICAL AND PHARMACOLOGICAL ASPECTS OF THE ALKALOIDS OF MALVACEAE sensu lato SPECIES: A REVIEW
Authors: Sobreira Ana , de Albuquerque Janderson , de Queiroz Wallace , de Souza Pedro , Fernandes Diégina , de Souza Maria
Published: March 2023

Malvaceae sensu lato is a family containing about 245 genera and 4,465 species mainly distributed across tropical and subtropical regions worldwide. Species of this family usually contain alkaloids with anti-inflammatory, antinociceptive, antiparasitic, antimicrobial and anticancer properties due to its secondary metabolites. In this context, this review aims to checklist the alkaloids isolated from Malvaceae sensu lato species, evaluating their chemical profile and pharmacological potential, providing a broad and concise overview of these secondary metabolites. The results were collected from scientific databases such as Web of Science, Scifinder, Pubmed, ScienceDirect and Google Scholar, using the keywords “Alkaloids” and “Malvaceae”. Several pharmacological/ biological activities are reported in literature for the most varied alkaloid nuclei, such as: vasorelaxation of the mesentery of rats (cryptolepinone), antitrypanosomal activity (waltherione) and anti-inflammatory and bronchodilator activity (vasicine), which highlights a succession of activities related to this class of secondary metabolites. Presented data report the importance of the Malvaceae sensu lato family, demonstrating the biological relevance of its alkaloids, in order to contribute to scientific knowledge and the development of new drugs.
Coliphages as indicators of primary wastewater treatment efficiency by constructed wetlands
Authors: Hernandez-Rivera Gisela , Santiago-Rodriguez Tasha M. , Toranzos Gary A.
Published: March 2023

Constructed wetlands are an efficient and cost-effective system for the treatment of wastewater that can be reused for diverse purposes, including irrigation; however, few studies have determined the efficiency of microbial removal by constructed wetlands in tropical regions. Therefore, the present study aimed to determine the microbial quality of the influent and effluent of a constructed wetland in Puerto Rico, using traditional bacterial indicators (i.e., thermotolerant coliforms and enterococci), as well as somatic and male-specific (F+) coliphages. Results showed that over 99.9 and 97.7% of thermotolerant coliforms and enterococci were removed after treatment by constructed wetlands, respectively. Notably, approximately 84.0% of male-specific (F+) coliphages were removed, while somatic and total coliphages exhibited differing removal percentages at different steps during treatment by constructed wetlands. The potential risk of the presence of enteric viruses in treated wastewater by constructed wetlands may increase when considering traditional bacterial indicators exclusively. The present study may aid in the efforts to determine public health concerns associated with the exposure of bioaerosols resulting from wastewater treatment by constructed wetlands.
Prediction of groundwater quality index in the Gaza coastal aquifer using supervised machine learning techniques
Authors: Aish Adnan M. , Zaqoot Hossam Adel , Sethar Waqar Ahmed , Aish Diana A.
Published: March 2023

This paper investigates the performance of five supervised machine learning algorithms, including support vector machine (SVM), logistic regression (LogR), decision tree (DT), multiple perceptron neural network (MLP-NN), and K-nearest neighbours (KNN) for predicting the water quality index (WQI) and water quality class (WQC) in the coastal aquifer of the Gaza Strip. A total of 2,448 samples of groundwater were collected from the coastal aquifer of the Gaza Strip, and various physical and chemical parameters were measured to calculate the WQI based on weight. The prediction accuracy was evaluated using five error measures. The results showed that MLP-NN outperformed other models in terms of accuracy with an R value of 0.9945–0.9948, compared with 0.9897–0.9880 for SVM, 0.9784–0.9800 for LogR, 0.9464–0.9247 for KNN, and 0.9301–0.9064 for DT. SVM classification showed that 78.32% of the study area fell under poor to unsuitable water categories, while the north part of the region had good to excellent water quality. Total dissolved solids (TDS) was the most important parameter in WQI predictions while and were the least important. MLP-NN and SVM were the most accurate models for the WQI prediction and classification in the Gaza coastal aquifer.
Structural Insight on GPR119 Agonist as Potential Therapy for Type II
Diabetes: A Comprehensive Review
Authors: Nema Priyanshu , Asati Vivek , Kendya Priyadarshi , Gupta Twinkle , Agarwal Shivangi , Kori Shivam , Kashaw Varsha , Iyer Arun K. , Kashaw Sushil Kumar
Published: March 2023

Diabetes Mellitus (DM) is a long-term metabolic condition that is characterized by excessive
blood glucose. DM is the third most death-causing disease, leading to retinopathy, nephropathy,
loss of vision, stroke, and cardiac arrest. Around 90% of the total cases of diabetic patients have Type
II Diabetes Mellitus (T2DM). Among various approaches for the treatment of T2DM. G proteincoupled
receptors (GPCRs) 119 have been identified as a new pharmacological target. GPR119 is distributed
preferentially in the pancreas β-cells and gastrointestinal tract (enteroendocrine cells) in humans.
GPR119 receptor activation elevates the release of incretin hormones such as Glucagon-Like
Peptide (GLP1) and Glucose Dependent Insulinotropic Polypeptide (GIP) from intestinal K and L
cells. GPR119 receptor agonists stimulate intracellular cAMP production via Gαs coupling to adenylate
cyclase. GPR119 has been linked to the control of insulin release by pancreatic β-cells, as well as
the generation of GLP-1 by enteroendocrine cells in the gut, as per in vitro assays. The dual role of the
GPR119 receptor agonist in the treatment of T2DM leads to the development of a novel prospective
anti-diabetic drug and is thought to have decreased the probability of inducing hypoglycemia.
GPR119 receptor agonists exert their effects in one of two ways: either by promoting glucose absorption
by β-cells, or by inhibiting α-cells' ability to produce glucose. In this review, we summarized potential
targets for the treatment of T2DM with special reference to GPR119 along with its pharmacological
effects, several endogenous as well as exogenous agonists, and its pyrimidine nucleus containing
synthetic ligands.
Glutathione S Transferase Theta1 and Mu1 (GSTT1 and GSTM1)
Deletion Among Autistic Population of India
Authors: Hegde Rajat , Hegde Smita , Kulkarni Suyamindra S. , Das Kusal K. , Gai Pramod B.
Published: March 2023

Introduction:

Oxidative stress is an imbalance between an organism's reactive oxygen
species (ROS) production and antioxidant defence capacity. Long-term oxidative stress
contributes to cellular ageing and plays a role in the pathogenesis of several diseases. Several
investigations indicated that oxidative stress has a role in the pathogenesis of ASD.

Objectives:

Present study was undertaken to record the association of GSTTT1 and GSTM1 null
genotype among the autistic population of India.

Methods:

Genomic DNA was isolated from 108 autistic children along with healthy agematched
control. The quality and quantity of the isolated genomic DNA were analysed. GSTT1
and GSTM1 null genotype was analysed using polymerase chain reaction with internal positive
control. Statistical analysis was performed using SPSS 15.0.

Results:

Present study included 85 males and 23 females with a mean age of 11.7 ± 3.5 and 75
males and 33 females with a mean age of 11 ± 2.0 in the control group. 32 (29.6%) autistic
cases showed null genotypes for GSTT1 and 21(19.4%) autistic children showed null genotypes
for GSTM1. 3 (2.85%) control children showed a null genotype for GSTT1 and 5 (4.6%) control
children showed a null genotype for GSTM1. The GSTT1 and GSTM1 null genotypes were
observed to be significantly associated with the risk of autism (p value-0.0001, OR-14.73, 95%
CI 4.35-49.90) and (p value-0.003, OR-4.731, 95% CI 1.71-13.08) respectively.

Conclusion:

The findings of our study suggested that GSTT1 and GSTM1 null genotype is one
of the potential risk factors for autism through oxidative stress mechanism in our population.
Evaluating social inclusion for the Bangladesh settlers in Nakasi: Post-urban regeneration
Authors: Pillay Shiu Nadan , Palaroan Rosalie Muertigue
Published: March 2023

This paper examines the concept of the government's 'social housing' policies for the urban poor and assesses their effectiveness. This research aimed to study an upgraded squatter settlement using subdivision and urban renewal concepts and gauge the social effects of the project as experienced by the residents. The paper also suggests how these state-sponsored programs can be improved and enhanced. Thus, it also reviews similar programs in other cities and countries as lessons to be learned. Due to the continuous population growth in the Suva-Nausori corridor, the demand for housing, exceptionally affordable housing, is exponentially growing, and this has led to real estate speculations and bubbles, substandard housing, overcrowding, squatting on public and private lands and homelessness, and this has led to other social problems. A field research study was carried out in 3 lower-income settlements within the affluent district of Nakasi. The findings revealed the need for more government interventions and a more strategic approach to rectify the severe shortfall of housing stock. The paper also notes the importance of the need for a paradigm shift in the state's housing policy to provide low-cost built housing, as opposed to just land length of service, which could not address some crucial issues experienced by the settlers.
The application of the make-a-match cooperative learning model to improve civics learning outcomes
Authors: Nurjanah Nurjanah , Samsuri Samsuri , Ramadan Syahri
Published: March 2023

The study aims to reveal the learning outcome in the civic education of Junior High School  2 Wates students by implementing the cooperative learning model “Make A Match” type with film media on competency standard understanding of various constitutions used in Indonesia. This research is classroom action research conducted in three cycles. The technique used for data collection was observation and achievement test. The data analysis technique used the procedure of data reduction, data presentation, and conclusion drawing. The results show increased student learning outcomes in the cognitive, affective, and psychomotor domains from the first to the second and third cycles. It can be concluded from this study that implementing the cooperative learning model of “Make A Match” type with film media can improve the learning outcomes in the civic education of the students of class VIII C Junior High School  2 Wates in the academic year of 2015/2016. Therefore it can be used as an alternative learning model in civic education.
Всплеск дрейфовой скорости электронов в гетероструктурах с двусторонним донорно-акцепторным легированием и цифровыми барьерами
Authors: Пашковский А.Б. , Богданов С.А. , Бакаров А.К. , Журавлев К.С. , Лапин В.Г. , Лукашин В.М. , Карпов С.Н. , Рогачев И.А. , Терешкин Е.В.
Published: March 2023

The nonlocal dynamics of electrons in pseudomorphic AlGaAs/GaAs/InGaAs heterostructures with double-sided donor-acceptor doping of AlGaAs barriers and additional digital potential barriers of short-period AlAs/GaAs superlattices around the doped regions has been theoretically studied. For the studied heterostructures, the introduction of digital barriers significantly, by 30–40%, increases the electrons drift velocity overshot when they enter the region of a strong field. The effect of localization of hot electrons on the states in AlAs/GaAs superlattices along the edges of the InGaAs quantum well is revealed. It is shown that taking this effect into account significantly increases the electrons drift velocity overshot, bringing it closer to the maximum theoretical limit for the model used – the drift velocity overshot in the undoped InGaAs bulk material.
Исследование фотолюминесценции в системе InGaAs/GaAs с квантовыми точками спектрального диапазона 1100 нм
Authors: Бабичев А.В. , Комаров С.Д. , Ткач Ю.С. , Неведомский В.Н. , Блохин С.А. , Крыжановская Н.В. , Гладышев А.Г. , Карачинский Л.Я. , Новиков И.И.
Published: March 2023

The results of studying the optical properties of InGaAs quantum dots are presented. Single-layer InGaAs quantum dots with a height of 5.3, 3.6 and 2.6 monolayers, as well as three-stacked layers of tunnel-uncoupled quantum dots with a height of 2.6 monolayers were formed by molecular–beam epitaxy according to the Stransky-Krastanov mechanism on GaAs substrates, using the partial capping and annealing technique. A decrease in the size of quantum dots makes it possible to carry out a blueshift of the photoluminescence spectrum maximum from 1200 nm to 1090 nm, and an increase in the number of QD layers makes it possible to compensate for the decrease in the peak intensity. It is shown that this type of quantum dots is suitable for creating the lasers active regions with a vertical microcavity for neuromorphic computing.
Структура и оптические свойства композитного метаматериала AsSb-Al-=SUB=-0.6-=/SUB=-Ga-=SUB=-0.4-=/SUB=-As-=SUB=-0.97-=/SUB=-Sb-=SUB=-0.03-=/SUB=-
Authors: Снигирев Л.А. , Ушанов В.И. , Иванов А.А. , Берт Н.А. , Кириленко Д.А. , Яговкина М.А. , Преображенский В.В. , Путято М.А. , Семягин Б.Р. , Касаткин И.А. , Чалдышев В.В.
Published: March 2023

Методом молекулярно-лучевой эпитаксии при низкой температуре с использованием прерываний роста успешно выращены эпитаксиальные слои AlxGa1-xAs1-ySby с содержанием алюминия x~60% и содержанием сурьмы y~3%. Путем последующего отжига в полупроводниковой матрице сформирована развитая система нановключений AsSb. Увеличенное окно прозрачности полученного метаматериала позволило надежно документировать широкую полосу поглощения света вблизи края межзонного поглощения полупроводниковой матрицы AlxGa1-xAs1-ySby. Параметры наблюдаемой полосы экстинкции позволяют связать такое поглощение света с плазмонным резонансом в системе нановключений AsSb. Ключевые слова: молекулярно-лучевая эпитаксия, рентгенодифракционный анализ, просвечивающая электронная микроскопия, оптические свойства, плазмонный резонанс.
Critical Criteria and Countermeasures for Mobile Health Developers to Ensure Mobile Health Privacy and Security: Mixed Methods Study (Preprint)
Authors: Rezaee Rita , Khashayar Mahboobeh , Saeedinezhad Saeed , Nasiri Mahdi , Zare Sahar
Published: March 2023

BACKGROUND

Despite the importance of the privacy and confidentiality of patients’ information, mobile health (mHealth) apps can raise the risk of violating users’ privacy and confidentiality. Research has shown that many apps provide an insecure infrastructure and that security is not a priority for developers.

OBJECTIVE

This study aims to develop and validate a comprehensive tool to be considered by developers for assessing the security and privacy of mHealth apps.

METHODS

A literature search was performed to identify papers on app development, and those papers reporting criteria for the security and privacy of mHealth were assessed. The criteria were extracted using content analysis and presented to experts. An expert panel was held for determining the categories and subcategories of the criteria according to meaning, repetition, and overlap; impact scores were also measured. Quantitative and qualitative methods were used for validating the criteria. The validity and reliability of the instrument were calculated to present an assessment instrument.

RESULTS

The search strategy identified 8190 papers, of which 33 (0.4%) were deemed eligible. A total of 218 criteria were extracted based on the literature search; of these, 119 (54.6%) criteria were removed as duplicates and 10 (4.6%) were deemed irrelevant to the security or privacy of mHealth apps. The remaining 89 (40.8%) criteria were presented to the expert panel. After calculating impact scores, the content validity ratio (CVR), and the content validity index (CVI), 63 (70.8%) criteria were confirmed. The mean CVR and CVI of the instrument were 0.72 and 0.86, respectively. The criteria were grouped into 8 categories: authentication and authorization, access management, security, data storage, integrity, encryption and decryption, privacy, and privacy policy content.

CONCLUSIONS

The proposed comprehensive criteria can be used as a guide for app designers, developers, and even researchers. The criteria and the countermeasures presented in this study can be considered to improve the privacy and security of mHealth apps before releasing the apps into the market. Regulators are recommended to consider an established standard using such criteria for the accreditation process, since the available self-certification of developers is not reliable enough.
Stress and job satisfaction over time, the influence of the managerial position: a bivariate longitudinal modelling of Wittyfit data (Preprint)
Authors: Colin Rémi , Dutheil Frédéric , Benson Amanda Clare , Dewavrin Samuel , Cornet Thomas , Lambert Céline , Pereira Bruno
Published: March 2023

BACKGROUND

The managerial position affects stress and job satisfaction of workers, but these influences have always been studied separately.

OBJECTIVE

We aimed to assess bivariate influence of the managerial position on workers’ stress and job satisfaction and the inter-relationship of these indicators over time.

METHODS

We have analyzed data from workers who use the Wittyfit software, collected annually between 2018 and 2021. Stress and job satisfaction were evaluated by self-report questionnaires. Job position (manager or employee) was provided by the software’s client companies.

RESULTS

Data of 704 workers were included in the study. Cross-sectional and longitudinal multivariate analyses revealed that managerial position improves job satisfaction (P<.001), but not stress (P=.4). Overall, while workers’ job satisfaction has improved (P<.001), stress has remained stable over time (P=.3). Three latent groups, with specific evolutionary multi-trajectory of stress and job satisfaction were identified in the sample (entropy=.80). Age and seniority, but not gender tended to influence managers’ and employees’ indicators. Over time, stress and job satisfaction have tended to negatively interconnect, in cross-section and in a cross-lagged manner (P<.001).

CONCLUSIONS

The managerial position improves workers’ job satisfaction but has no effect on stress. Sociodemographics including age and seniority, but not gender, can affect this relationship. Stress and job satisfaction can influence each other, both cross-sectionally and over time. To be more effective, organizations should implement holistic strategies targeting multiple indicators.

CLINICALTRIAL

Clinicaltrials.gov: NCT02596737.
The Effectiveness of Early Food Introduction in Preventing Childhood Allergic Diseases: Protocol for a Systematic Review and Meta-Analysis (Preprint)
Authors: Abang Abdullah Aisha Fadhilah , Muhamad Nor Asiah , Ab Ghani Rimah Melati , Maamor Nur Hasnah , Leman Fatin Norhasny , Too Chun Lai , Ismail Intan Hakimah , Mohd Zulkefli Nor Afiah , Mohd Nazan Ahmad Iqmer Nashriq , Md Said Salmiah
Published: March 2023

BACKGROUND

Allergic diseases affect around 40% of the pediatric population worldwide. The coexistence of asthma, allergic rhinitis, eczema, and food allergy renders allergy treatment and prevention challenging. Infant feeding strategies recommend avoiding allergenic foods to prevent allergy development and anaphylaxis. However, recent evidence suggests that early consumption of food allergens during weaning in infants aged 4-6 months could result in food tolerance, thus reducing the risk of developing allergies.

OBJECTIVE

The aim of this study is to systematically review and carry out a meta-analysis of evidence on the outcome of early food introduction for preventing childhood allergic diseases.

METHODS

We will conduct a systematic review of interventions through a comprehensive search of various databases including PubMed, Embase, Scopus, CENTRAL, PsycINFO, CINAHL, and Google Scholar to identify potential studies. The search will be performed for any eligible articles from the earliest published articles up to the latest available studies in 2023. We will include randomized controlled trials (RCTs), cluster RCTs, non-RCTs, and other observational studies that assess the effect of early food introduction to prevent childhood allergic diseases.

RESULTS

Primary outcomes will include measures related to the effect of childhood allergic diseases (ie, asthma, allergic rhinitis, eczema, and food allergy). PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines will be followed for study selection. All data will be extracted using a standardized data extraction form and the quality of the studies will be assessed using the Cochrane Risk of Bias tool. A summary of findings table will be generated for the following outcomes: (1) total number of allergic diseases, (2) rate of sensitization, (3) total number of adverse events, (4) improvement of health-related quality of life, and (5) all-cause mortality. Descriptive and meta-analyses will be performed using a random-effects model in Review Manager (Cochrane). Heterogeneity among selected studies will be assessed using the I2 statistic and explored through meta-regression and subgroup analyses. Data collection is expected to start in June 2023.

CONCLUSIONS

The results acquired from this study will contribute to the existing literature and harmonize recommendations for infant feeding with regard to the prevention of childhood allergic diseases.

CLINICALTRIAL

PROSPERO CRD42021256776; https://tinyurl.com/4j272y8a

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/46816
Bonhoeffer’s Theology of Resistance in the Context of Global Justice
Authors: Longkumer Bendangrenla S
Published: March 2023

Dietrich Bonhoeffer, the German philosopher and theologian whole lived during the Nazi Germany era, was a “lone voice in the wilderness” whose work on the theology of sociality advocated for a community which he calls the “visible community” and was “beyond all earthly ties”. In the Nazi Germany context, it ran counter current to the German nationalist propaganda of the volk which had aggressively made its way into all aspects of the German society including the church. Bonhoeffer’s theology of sociality opens up the possibility of Christianity as not merely a religious institution but a movement towards inclusivity. The study of Bonhoeffer’s theology of sociality becomes significant in formulating a new concept of community for contemporary times. The foundation of communities formed along earthly ties whether be it religious, political, cultural, social and in our context caste or ethnic almost always inevitably turn into oppressive powers. This radical demand of renunciation of earthly ties, yet the call to live for the sake of the ‘neighbour’ and to bear the ‘cost of discipleship’ is counter-intuitive to contemporary individualistic and consumerist impulses, which therefore opens up the question of how one is to live in the modern world in the face of modern powers. This opens up the possibility of exploring the relationship between the individual and the community and the ethical responsibility that this community must fulfil towards the oppressed and the suffering. In the context of global justice, an understanding of Bonhoeffer’s theology of sociality offers the articulation of an inclusive community that does not discriminate or oppress.
Understanding Therapeutic drug monitoring (TDM) at a glance
Authors: Noman Abdullah Al , Chakraborty Anupama , Akter Honufa , Binti Raisa Mustafa
Published: March 2023

This paper gives an overview of therapeutic drug monitoring. The primary objectives of TDM are to prevent therapeutic failures carried on by poor compliance or prescribing a drug at a dose that is too low, as well as negative or toxic effects brought on by an excessive dose. Moreover, it gives information about when and what type of drug needs therapeutic drug monitoring. Like the drug which has a short therapeutic window they require therapeutic monitoring because it can cause toxicity or no therapeutic effect. However, the appropriate use of TDM is not only the simple measurement of patient blood drug concentration and the comparison of its target range but also TDM plays an important role in the therapeutic medication by ensuring safety and effectiveness also with individualization of these medications, desired clinical targets, dosage history, sampling time in relation to the dose patient’s response these factors needed to be considered while interpreting drug concentration measurements to achieve the optimal response with minimal toxicity. So TDM can be considered as a combined approach encompassing pharmaceutical, pharmacokinetic, pharmacodynamic techniques and analyses.
institución de “el método en etnografía”
Authors: Lopez Noelia Soledad
Published: March 2023

En este texto se propone pensar de qué manera, un proyecto centrado en una ontología de la creación permite pensar la institución de una nueva manera de conocer: la etnografía. ¿Qué podría conectar los cien años del nacimiento de Castoriadis con el centenario de una obra como Los argonautas del pacífico occidental de Malinowski?, ¿cómo se discuten sus vigencias, qué los conecta hoy, cien años después?, ¿puede una antropología filosófica estar en relación con los dilemas del trabajo de campo etnográfico?
Isolation and Molecular Characterization of the Naringinase Producing Micro-organisms for the Bio-transformation of Flavonoid
Authors: Sindhe Ananda , Lingappa K.
Published: March 2023

Naringin is a flavanone found in citrus fruits and vegetables which are responsible for the asperity, due to which citrus fruit are unable to consume and from which we are unable to get the valuable nutrition in our body. To overcome this asperity in citrus fruits, present investigation is carried out, which provides a detailed report of isolation and screening of naringinase producing micro-organisms from different samples collected from Kalyan -Karnataka region, India. A sum of around 50 strains were isolated from 20 different samples which showed the positive result for naringinase activity, among 50 strains obtained 42 strains are fungi and remaining 8 were bacteria which showed good to moderate results in preliminary screening by 1% FeCl3 method, further 5 fungi isolates which showed a good naringinase activity in submerged fermentation were assayed by Spectrophotometric method. As a result, KLA-80 showed a maximum result with an activity of 559 U/ml. Further from the identification of the isolate KLA-80 by BLAST analysis found to be having similarity with Aspergillus flavus and the accession number of OQ152018 is obtained.
A Study of Virtualization Techniques Applied in Cloud Computing Environment
Authors: Kumari Neha , Singh Dr. Uday Narayan
Published: March 2023

Abstract: The fastest-growing internet technology today is cloud computing. On-demand network access to a shared pool of reconfigurable resources is possible. A fundamental component of cloud computing is virtualization, which enables real resources to be divided into virtual resources so they can be shared among other virtual machines. Utilizing this virtualized resource can help you use less real equipment, servers, and storage space. Modern technologies like cloud computing expand the functional possibilities, elastic resource management, and collaborative execution style of applications. Virtualization, which enables business or academic IT resources through ondemand allocation dynamically, is the core component of cloud computing. The resources come in a variety of shapes, including client, server, storage, network, and application. This essay focuses on how virtualization increases the resources' elasticity in a cloud computing context. This study also provides a thorough analysis of open source virtualization approaches, problems, and future research directions.
Implementation of Pretrained VGG16 Model for Rice Leaf Disease Classification using Image Segmentation
Authors: Suseno Jody Ririt Krido , Minarno Agus Eko , Azhar Yufis
Published: March 2023

Rice is an agricultural sector that produces rice which is one of the staple foods for the majority of the population in Indonesia. In the cultivation of rice plants there are also factors that affect rice production and are not realized by farmers causing that they are late in handling and diagnosing symptoms and making rice production decline. Therefore, it is necessary to have an early diagnosis of rice plants to identify them correctly, quickly and accurately. Machine learning is one of the classification techniques to detect various plant diseases such as rice plants. There are several studies on machine learning using the Convolutional Neural Network with the VGG16 model to classify rice leaf diseases and using Image Segmentation techniques on rice leaf datasets for make the image becomes a form that is not too complicated to analyze. The data used in this research is Rice Leaf Disease which consists of 3 classes including Bacterial leaf blight, Brown spot, and Leaf smut. Then segmentation is carried out using two techniques, namely threshold and k means. Then data augmentation for make dataset used has a large and varied number and training using VGG16 model with hyperparameter tuning and obtained 91.66% accuracy results for scenarios with the k-means dataset.
Efficient algorithms for quantum information bottleneck
Authors: Hayashi Masahito , Yang Yuxiang
Published: March 2023

The ability to extract relevant information is critical to learning. An ingenious approach as such is the information bottleneck, an optimisation problem whose solution corresponds to a faithful and memory-efficient representation of relevant information from a large system. The advent of the age of quantum computing calls for efficient methods that work on information regarding quantum systems. Here we address this by proposing a new and general algorithm for the quantum generalisation of information bottleneck. Our algorithm excels in the speed and the definiteness of convergence compared with prior results. It also works for a much broader range of problems, including the quantum extension of deterministic information bottleneck, an important variant of the original information bottleneck problem. Notably, we discover that a quantum system can achieve strictly better performance than a classical system of the same size regarding quantum information bottleneck, providing new vision on justifying the advantage of quantum machine learning.
Amplitude Estimation from Quantum Signal Processing
Authors: Rall Patrick , Fuller Bryce
Published: March 2023

Amplitude estimation algorithms are based on Grover's algorithm: alternating reflections about the input state and the desired outcome. But what if we are given the ability to perform arbitrary rotations, instead of just reflections? In this situation, we find that quantum signal processing lets us estimate the amplitude in a more flexible way. We leverage this technique to give improved and simplified algorithms for many amplitude estimation tasks: we perform non-destructive estimation without any assumptions on the amplitude, develop an algorithm with improved performance in practice, present a new method for unbiased amplitude estimation, and finally give a simpler method for trading quantum circuit depth for more repetitions of short circuits.
АНУ-ын Хятад судлалын гол төлөөлөгчийн нэг Жонатан Спенсийн бүтээлүүдийн тухайд
Authors: J. Battur
Published: March 2023

The article presents a brief introduction on the American Sinology and the importance of studying the works of Jonathan Spencer, a major Chinese history researcher, and their relevance to Mongolian history. Also, Mongolian contemporary researchers have a need to pay attention to other countries which have successful Sinology specially the American Sinology publications in order to study China more deeply and broadly.
The semantic and syntactic properties of the mandarin 把 and 被¬ constructions: an aspectual approach
Authors: B. Bolor
Published: March 2023

Зохиогч энэхүү өгүүлэлдээ орчин цагийн хятад хэлний 把 (ba), 被 (bei) хоёр бүтцийг авч үзлээ. Ингэхдээ 把,被 хоёрыг өмнөх судлаачдын тодорхойлсончлон хэл зүйн бүтээвэр биш харин үйл үг гэж үзэн, 把,被 бүтэц бүхий өгүүлбэрийг зургаан төрөлд хувааж, тус бүрийг нь хэлний бодит жишээ баримтанд тулгуурлан шинжилсэн бөгөөд өгүүллийнхээ төгсгөлд 把,被 хоёр бүтцийн утга зүйн болон хэл зүйн онцлог шинжийг Америкийн хэл шинжээч агсан Карлота С.Смитийн дэвшүүлсэн Байдлын хоёр бүрэлдэхүүнт онолын (Two-component Theory of Aspect) үүднээс тайлбарлах нь зохистой гэж дүгнэв.
Гадаад хэлний чадамжийн шатлал боловсруулах аргууд
Authors: M. Odontuya
Published: March 2023

In the present study we conducted a comparative study on research publications by international researchers for the purpose of defining language competence of foreign language learners in accordance with international examination standard levels and competence scales as well as enhancing teaching contents and curriculums in conformity with the appropriate levels and scales. Thus, an overview of scales, objectives and classifications of foreign language competence and methods of developing scales was provided.
Япон хэл суралцагчдын үгийн сангийн нөөцийг нэмэгдүүлэхэд сторителлинг аргыг хэрэглэх нь
Authors: B. Khishigdelger , Ayako Nakamura
Published: March 2023

In this research, trying to verify learners' vocabulary development through the practical lessons using storytelling in Japanese language education. In the lessons, targeting sixth graders, took not only storytelling but also story related activities by the concept of whole language approach which connects other subjects. Based on the results of the practical lessons,the storytelling promotes output skill. In the class, the joint storytelling had been conducted for 10 to 15 minutes each time in a single story and continuedonce a week, 8 times in total. In other words, the whole lesson was taken 80 to 120 minutes in total. Each class took 40 minutes that is taken only a couple of hours to retell the story. This result demonstrate that it is possible touse storytelling in Japanese language education. In addition, the class evaluation for the practical lessons increased learners' vocabularies and gained high satisfaction. As a result of pre and post tests, learners are understanding meaning of the word in meaningful sentences more than single separated word.
Risk management in SMEs: Status quo and areas for future research in the German leasing industry
Authors:   University of Portsmouth, Department of Economics and Finance, United Kingdom, Glaser Christian , Henschel Thomas ,   University of Verona, Department of Business Administration, Italy, HTW Hochschule für Technik und Wirtschaft Berlin
Published: March 2023

PURPOSE: The purpose of the present research note is to give an overview of research in the field of risk management in leasing SMEs as well as to present fields for future research. It intends to encourage other researchers to fill the current gap in research on risk management in general and on risk management in (German leasing) SMEs in particular. DESIGN/METHOD: The research note is based on interviews with 40 German leasing firms, thereof 35 SMEs. Qualitative research was chosen due to the nascent knowledge area and to explore cause-effect- -relationships as well as to gain a deeper understanding of the practical requirements on risk management. RESULTS/FINDINGS: A research framework was presented based on the findings of the literature review. Based on the interviews, the framework could be drilled down into more operative, leasing-specific topics. Amongst others, it could be found that the risk management organisation is greatly shaped by the underlying risk strategy, the motivation for risk management, as well as the essential risks. These three elements form the basis for the operative and strategic risk management practice. Furthermore, it was differentiated in the different lifecycle phases of risk management. ORIGINALITY/VALUE: The presented research note is based on the first known research in the field of risk management for German leasing SMEs with a comparable number of interviews. Therefore, this research note includes a high degree of novelty. Adapting the findings in practice as well as combining it with other research questions might add significant value to risk management research as well as practice not only limited to the German leasing industry. KEYWORDS: risk management, small and medium-sized enterprises (SMEs), leasing, financial services, Germany. JEL: A12, D81, G32
A scientometric view at real estate issues in risk management: Management research versus finance research
Authors:   Czestochowa University of Technology, Faculty of Management, Poland, Gorzeń-Mitka Iwona
Published: March 2023

PURPOSE: The aim of the paper is to map the thematic landscape of real estate research in the context of risk management and to contribute to the identification and exploration of relationships between specific constructs in the management versus finance research. DESIGN/METHOD: This article applies some scientometric techniques. A combination of topic mapping has been used, as well as the author’s and journal co-citation analyses, and overlay visualisation of main and new topics in these fields. For the purposes of bibliometric analysis, the following tools and techniques have been used: trend analysis of the number of publications, citation analysis, the word co-occurrence method, and clustering (cluster analysis). The VOSviewer software and the data analysis tools available in the SCOPUS database were used for the analysis. RESULTS/FINDINGS: The main findings of this study are: the study of real estate issues in the context of risk management is a relatively new trend in academic research, which has been intensified over the past 10 years; the problems are studied mainly from the point of view of management research, financial research and engineering research; most of the leading researchers in this field combine aspects of management with aspects of finance in their studies; a relatively new trend in the study of the real estate issues in the context of risk management is the research on the use of artificial intelligence and the analysis of the impact of climate change on these processes. ORIGINALITY/VALUE: This article makes the important contribution to real estate research in the context of risk management in management research and finance research. The analyses revealed some patterns of convergence and divergence and the diversity of topics, specialisation, and interdisciplinary engagement in the context of real estate issues in the context of risk management in management and finance research, thus offering the latest insights into the state-of-the-art of the fields. KEYWORDS: real estate, risk management, scientometric analysis. JEL: G32, R39