bluuebunny/crossref_metadata_2025 huggingface dataset:
Economic Development Ideas of Regional Convergence Industry Based on Artificial Intelligence Multimedia Background
Authors: Chen Zhong , Liu Yishu
Published: November 2021

Today, with the development of the times and the advancement of science and technology, informatization has gradually become an important standard for measuring the state of national development in the course of national development. The artificial intelligence multimedia technology has been developed under the background of informationization and has gradually become an important means to achieve national development and regional economic progress. The impact often depends not only on the economic attributes of the industry but also on the economic attributes of urban planning. Countries and regions with high levels of regional integration and industrial economic development have begun to inject economic knowledge and methods into regional integration and industrial economic processes, which are used to solve or alleviate problems and contradictions in the process of urban and rural construction and development. It can be seen that industrial economy and regional integration are not only a spatial phenomenon but also an economic phenomenon. Based on the needs of the development of urban planning discipline theory and the era of national industrial economic integration, this paper puts forward the research methods and ideas of this paper and combines current multimedia backgrounds and their development trends to analyze key innovations and research frameworks, incorporating the main theoretical research elements into the concept of “combination” of traditional Chinese philosophy, aiming at the main problems and contradictions in the process of China’s industrial economic development, respectively, the cultural economy and industrial economy, and the integration of public economy and environmental economy, land economy, and housing economy, a new urbanization development strategy of population economy and regional economic competition.
SRC‐3 Knockout Attenuates Myocardial Injury Induced by Chronic Intermittent Hypoxia in Mice
Authors: Wang Wanyu , Gu Hongbo , Li Weihua , Lin Yihua , Yao Xiangyang , Luo Wen , Lu Fang , Huang Shenhui , Shi Yonghong , Huang Zhengrong
Published: November 2021

This study investigated the effects of chronic intermittent hypoxia (CIH), a model of sleep apnea syndrome (SAS), on cardiac function. SRC‐3 was extremely lowly expressed in the adult mouse heart tissue, while SRC‐3 was highly expressed in the adult mouse heart tissue after CIH, suggesting that SRC‐3 is involved in CIH model. We further studied the role of SRC‐3 in CIH‐induced myocardial injury in mice. Twenty‐four healthy Balb/c male mice (n = 16, wild type; n = 8, SRC‐3 knockout (SRC3‐KO)) were randomly divided into three groups: air control (Ctrl), CIH, and CIH+SRC3‐KO. Mice were exposed to CIH for 12 weeks. qRT‐PCR was used to evaluate cardiac expression of the following genes: 11HSD1, 11HSD2, GR, MR, COX‐2, OPN, NOX2, HIF‐1‐α, IL‐1β, IL‐6, iNOS, TNF‐α, PC‐1, and TGF‐β. Enzymatic levels of SOD, CAT, MDA, NOS, and NO in the mouse hearts were determined using commercially available kits. Immunohistochemistry (IHC) was used to evaluate NF‐κB expression in cardiac tissues. A transmission electron microscope (TEM) was used to evaluate myocardial ultrastructure. TUNEL staining was used to assess myocardial cell apoptosis. CIH induced cardiac damage, which was ameliorated in the SRC‐3 KO mice. CIH significantly increased the heart‐to‐body weight ratio, expression of all aforementioned genes except 11HSD1, GR, and MR, and increased the levels of MDA, NOS, NO, and NF‐κB, which were attenuated in the SRC‐3 KO mice. The CIH group had the lowest SOD and CAT levels, which were partially recovered in the CIH+SRC3‐KO group. 11HSD2 gene expression was elevated in both the CIH and CIH+SRC3‐KO groups compared to the Ctrl group. The CIH group had severe myocardial cell apoptosis and mitochondrial dysfunction, which were alleviated in the CIH+SRC3‐KO group. CIH causes cardiac damage through inducing oxidative stress and inflammation. Knockout of SRC‐3 ameliorates CIH‐induced cardiac damage through antagonizing CIH‐triggered molecular changes in cardiac tissue.
Phenolic Profile, Nutritional Composition, Functional Properties, and Antioxidant Activity of Newly Grown Parthenocarpic and Normal Seeded Tomato
Authors: Dominic Sajid , Hussain Abdullah Ijaz , Shahid Chatha Shahzad Ali , Ali Qasim , Aslam Nosheen , Sarker Satyajit Dey , Shah Chishti Saeed Ahmad , Ali Shafaqat , Maqbool Saliha , El-Sheikh Mohamed A. , Alyemeni Mohammed Nasser
Published: November 2021

The aim of the study was to compare the physicochemical parameters, sugar, vitamin C, and phenolic profiles in five genotypes of local indeterminate tunnel tomato hybrid (LITTH) (LITTH-778, LITTH-784, LITTH-786, LITTH-788, and LITTH-790) of natural parthenocarpic tomato (NPT) and normal seeded tomato (NST). Samples were collected from the experimental fields of Ayub Agricultural Research Institute, Faisalabad, Pakistan. Physical parameters (fruit shape, fruit weight, fruit length, fruit width, number of seeds per fruit, and shelf-life) and chemical composition (moisture, ash, crude fat, crude fiber, total carbohydrate, crude protein, and vitamin C) of NPT and NST were analyzed by reported methods. The methanolic extracts of tomato pulp were prepared by shaking and extracts were assayed for antioxidant activity. Sugar contents and phenolic profile of NPT and NST were estimated using HPLC method. Weight and size of NPT were less and smaller than the NST. Moreover, NPT were seedless with longer shelf-life and had more phenolic and flavonoid contents than the NST. HPLC analysis revealed that chlorogenic acid, gallic acid, and p-coumaric acid were major phenolics in methanol (polar solvent) extracts of NST, and caffeic acid, gallic acid, and p-coumaric acid in NPT extract. NPT contained higher concentration of sugar contents, but lower concentration of vitamin C than NST. In 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging assay, NPT fruit extracts showed high scavenging activity with the 50% inhibitory concentration (IC50) value of 22.56 μg/mL compared to NST fruit extracts having IC50 29.49 μg/mL. This study provided useful information for farmers and nutritionists.
Using Smart Card Data of Metro Passengers to Unveil the Urban Spatial Structure: A Case Study of Xi’an, China
Authors: Cheng Guohong , Sun Shichao , Zhou Linlin , Wu Guanzhong
Published: November 2021

This study adopted smart card data collected from metro systems to identify city centers and illustrate how city centers interacted with other regions. A case study of Xi’an, China, was given. Specifically, inflow and outflow patterns of metro passengers were characterized to measure the degree of population agglomeration of an area, i.e., the centricity of an area. On this basis, in order to overcome the problem of determining the boundaries of the city centers, Moran’s I was adopted to examine the spatial correlation between the inflow and outflow of ridership of adjacent areas. Three residential centers and two employee centers were identified, which demonstrated the polycentricity of urban structure of Xi’an. With the identified polycenters, the dominant spatial connections with each city center were investigated through a multiple linkage analysis method. The results indicated that there were significant connections between residential centers and employee centers. Moreover, metro passengers (commuters mostly) flowing into the identified employee centers during morning peak-hours mainly came from the northern and western area of Xi’an. This was consistent with the interpretation of current urban planning, which validated the effectiveness of the proposed methods. Policy implications were provided for the transport sector and public transport operators.
Marked Increase of Gamma-Glutamyltransferase as an Indicator of Drug-Induced Liver Injury in Patients without Conventional Diagnostic Criteria of Acute Liver Injury
Authors: Weber Sabine , Allgeier Julian , Denk Gerald , Gerbes Alexander L.
Published: November 2021

Introduction: Clinically significant drug-induced liver injury (DILI) is defined by elevations of alanine aminotransferase (ALT) ≥5 times the upper limit of normal (ULN), alkaline phosphatase (ALP) ≥2 × ULN, or ALT ≥3 × ULN and total bilirubin TBIL >2 × ULN. However, DILI might also occur in patients who do not reach those thresholds and still may benefit from discontinuation of medication. Methods: Fifteen patients recruited for our prospective study on potentially hepatotoxic drugs were included. DILI diagnosis was based on RUCAM (Roussel Uclaf Causality Assessment Method) score and expert opinion and was supported by an in vitro test using monocyte-derived hepatocyte-like (MH) cells. Results: Median RUCAM score was 6 (range 4–8), indicating that DILI was possible or probable in all cases. The predominant types of liver injury were mixed (60%) and cholestatic (40%). While no elevation above 2 × ULN of ALP and TBIL was observed, gamma-glutamyltransferase (GGT) above 2 × ULN was identified in 8 of the patients. Six of the 15 patients did not achieve full remission and showed persistent elevation of GGT, which was significantly associated with peak GGT elevation above 2 × ULN (p = 0.005). Conclusion: Here we present a case series of patients with liver enzyme elevation below the conventional thresholds who developed DILI with a predominant GGT elevation leading to drug withdrawal and/or chronic elevation of liver parameters, in particular of GGT. Thus, we propose that DILI should be considered in particular in cases with marked increase of GGT even if conventional DILI threshold levels are not reached, resulting in discontinuation of the causative drug and/or close monitoring of the patients.
Supplemental Scleral Buckle for the Management of Rhegmatogenous Retinal Detachment by Pars Plana Vitrectomy: A Meta-Analysis of Randomized Controlled Trials
Authors: Rosenberg Daniel M. , Ghayur Huphy S. , Deonarain Deven M. , Sarohia Gurkaran S. , Phillips Mark R. , Garg Sunir , Bakri Sophie J. , Wykoff Charles C. , Chaudhary Varun
Published: November 2021

Objectives: The present review aimed to synthesize evidence from randomized controlled trials (RCTs) that compared outcomes of pars plana vitrectomy (PPV) with and without a supplementary scleral buckle (SB) for management of rhegmatogenous retinal detachment (RRD). Methods: The authors searched MEDLINE, Embase, and CENTRAL to identify RCTs in English that compared PPV with and without supplemental SB. Risk of bias was assessed according to the Cochrane Risk of Bias 2 tool. We present risk ratios (RRs), mean differences (MDs), and 95% confidence intervals (CIs) estimated using random-effects meta-analyses. Results: We identified 6 RCTs involving 705 eyes. Primary reattachment (6 studies, 345 eyes PPV, 324 eyes PPV + SB; RR 0.99, 95% CI 0.93–1.06, I2 = 0%, p = 0.78) and final anatomic success rates (4 studies, 272 eyes PPV, 267 eyes PPV + SB; RR 1.00, 95% CI 0.98–1.02, I2 = 0%, p = 0.89) were similar between the 2 groups. Postoperative visual acuity improvement (5 studies, 244 eyes PPV, 222 eyes PPV + SB; MD 6.09 letters, 95% CI -0.47–12.64, I2 = 69%, p = 0.07) and frequency of adverse events (6 studies, 1,294 observations PPV, 1,221 observations PPV + SB; RR 0.76, 95% CI 0.57–1.01, I2 = 25%, p = 0.06) likewise did not differ significantly between the treatment groups. Conclusion: Low-certainty evidence from RCTs did not demonstrate a benefit in placement of a supplemental SB during vitrectomy for management of RRD in the current analysis. Additional high-quality trials are needed to provide more precise estimates of the effect.
Hospital Readmissions and Mortality Among Fee‐for‐Service Medicare Patients With Minor Stroke or Transient Ischemic Attack: Findings From the COMPASS Cluster‐Randomized Pragmatic Trial
Authors: Bushnell Cheryl D. , Kucharska‐Newton Anna M. , Jones Sara B. , Psioda Matthew A. , Johnson Anna M. , Daras Laurie C. , Halladay Jacqueline R. , Prvu Bettger Janet , Freburger Janet K. , Gesell Sabina B. , Coleman Sylvia W. , Sissine Mysha E. , Wen Fang , Hunt Gary P. , Rosamond Wayne D. , Duncan Pamela W.
Published: November 2021

Background

Mortality and hospital readmission rates may reflect the quality of acute and postacute stroke care. Our aim was to investigate if, compared with usual care (UC), the COMPASS‐TC (Comprehensive Post‐Acute Stroke Services Transitional Care) intervention (INV) resulted in lower all‐cause and stroke‐specific readmissions and mortality among patients with minor stroke and transient ischemic attack discharged from 40 diverse North Carolina hospitals from 2016 to 2018.

Methods and Results

Using Medicare fee‐for‐service claims linked with COMPASS cluster‐randomized trial data, we performed intention‐to‐treat analyses for 30‐day, 90‐day, and 1‐year unplanned all‐cause and stroke‐specific readmissions and all‐cause mortality between INV and UC groups, with 90‐day unplanned all‐cause readmissions as the primary outcome. Effect estimates were determined via mixed logistic or Cox proportional hazards regression models adjusted for age, sex, race, stroke severity, stroke diagnosis, and documented history of stroke. The final analysis cohort included 1069 INV and 1193 UC patients (median age 74 years, 80% White, 52% women, 40% with transient ischemic attack) with median length of hospital stay of 2 days. The risk of unplanned all‐cause readmission was similar between INV versus UC at 30 (9.9% versus 8.7%) and 90 days (19.9% versus 18.9%), respectively. No significant differences between randomization groups were seen in 1‐year all‐cause readmissions, stroke‐specific readmissions, or mortality.

Conclusions

In this pragmatic trial of patients with complex minor stroke/transient ischemic attack, there was no difference in the risk of readmission or mortality with COMPASS‐TC relative to UC. Our study could not conclusively determine the reason for the lack of effectiveness of the INV.

Registration

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT02588664.
Endogenous Vertical Differentiation, Variety, and the Unequal Gains from Trade
Authors: Heins Gunnar
Published: November 2021

How unequal are the gains from trade? This paper develops a structural framework to quantify the consequences of international trade on welfare of consumers across the income distribution, allowing for nonhomothetic demand and endogenous quality choices by firms. Using random coefficients demand estimation techniques, I infer demand and supply parameters, as well as household-specific price indexes for more than 3,000 distinct industries and find the gains from trade to be moderately unequal except in wealthier and small economies. Further, not accounting for endogenous vertical differentiation would overstate the impact of trade on cost-of-living inequality by close to 50%.
Multinational Federalism, Fiscal Relations and Development in Ethiopia
Authors: Boucher François
Published: November 2021

In this paper, I explore the tensions between multinational federalism and the developmental state in Ethiopia and draw attention on the fiscal and economic dimensions of multinational federalism. In the first section, I explain that the purpose of multinational federalism is to protect minority nations from aggressive, assimilationist and centralizing forms of majoritarian nation-building. As such, multinational federalism only makes sense within a certain context, often associated with Western states containing a clear national majority attempting to assimilate minorities. I explain why authors have argued, albeit within some reservations, that this context obtains in the case of Ethiopia. In the second section, I discuss the fiscal and economic dimensions of minority nationalism accommodation in Western states. In the third section, I explore the contextual differences between Ethiopia and Western plurinational states and explain their relevance for assessing the tension between federalism and development in Ethiopia. I argue that although minority nations in the West rarely enjoy full fiscal autonomy, the prospect for fiscal decentralization in Ethiopia is even more limited and this is not entirely unjustified from a contextualist point of view paying attention to feasibility constraints.
What does Voluntary Delisting Tell us about Corporate Governance in Kuwait?
Authors: Almutairi Shahad M.
Published: November 2021

Despite the adoption of the mixed approach in the application of corporate governance (CG), largely based on the ‘comply or explain’ principle, the Kuwaiti corporate governance system still faces major limitations that have become particularly noticeable from the event of voluntary delisting by a slew of companies after the new Kuwaiti Code of Corporate Governance (KCCG) came into force in 2016. One apparent limitation is caused by the widespread culture of non-compliance, an observation supported by the Capital Market Authority Report on Voluntary Delisting from 2010 to 2016. Empirical analysis was conducted on a sample of 29 companies, all of which were delisted during application of the new KCCG of 2015 until April 2020. This voluntary delisting also indicates other salient limitations such as deficiencies in the CG legal framework, the asymmetrical concentration of share ownership in the hands of larger shareholders, and the passivity of shareholders in Kuwaiti-listed shareholding companies.
Fossil Alloceltidoxylon, Allonymphaea, Arecocaryon, Paralnoxylon and Paranyssa and extant Komaroviopsis, Marcanodendron, and Papyrocactus (Magnoliophyta), new replacement generic names
Authors: DOWELD ALEXANDER B.
Published: November 2021

Eight new generic replacement names were validated. The new fossil wood generic name Alloceltidoxylon is validated to replace later homonym, Scottoxylon Wheeler & Manchester (non Scotoxylon Vogellehner). The new fossil generic name Allonymphaea is proposed to replace later homonym, Thiebaudia M. Chandler (non Thiebautia Colla nec Thibaudia Ruiz et Pavon ex Jaume St.-Hilaire), based on leaf remains. The new fossil generic name Arecocaryon, based on fruit remains, is proposed to replace the later homonym Friedemannia M.E. Collinson, Manchester& V. Wilde (non Friedmannia Chantanachat & Bold, Algae). The new fossil wood generic name Paralnoxylon is validated to replace later homonym, Cantia Stopes (non Kantia Pia). The new fossil generic name Paranyssa, based on fossil leaves, is validated to replace later homonym, Browniea Manchester & Hickey (non Brownea Jacquin). Three new generic names for extant flowering plants were validated: Komaroviopsis replaces Komarovia Korovin (non Komaroffia O. Kuntze) and Komaroviopsideae trib. nov. replaced invalid Komarovieae, Marcanodendron instead of Uladendron Marcano-Berti (non fossil Ulodendron Lindley & Hutton) and Papyrocactus replaces Toumeya Britton & Rose (non Tuomeya W.H. Harvey, Algae). The new combinations Alloceltidoxylon eocenicum, Allonymphaea rayaniensis, Arecocaryon messelense, Paralnoxylon arborescens, Paranyssa serrata, Komaroviopsis anisosperma, Marcanodendron codesuri, and Papyrocactus papyracanthus are proposed.
                Alloceltidoxylon, Allonymphaea, Arecocaryon, Komaroviopsis, Marcanodendron, Paralnoxylon, Paranyssa, Papyrocactus, new replacement generic names, Komaroviopsideae trib. nov.
Salacia juradoi (Celastraceae), a new species from coastal Ecuador
Authors: CORNEJO XAVIER , LOMBARDI JULIO A.
Published: November 2021

Salacia juradoi (Celastraceae), a new species of tree from the forest remnants of Guayaquil in coastal Ecuador, is here described and illustrated, and the affinities with closely morphologically related taxa is commented. The conservation status of Salacia juradoi is here assessed as Endangered.
Redescription of Paracles vulpina (Hübner, [1825]) (Lepidoptera: Erebidae), with comments of the aquatic habit of larval instars
Authors: BECCACECE HERNÁN MARIO , VIGLIONE GABRIELA BENTANCUR , GRAFF PAMELA , MORELLI ENRIQUE
Published: November 2021

The genus Paracles Walker, 1855 is one of the most diverse genera present in Arctiinae and some species have larvae with aquatic habits. Several larvae were found swimming in flooded areas in different grasslands and were bred to adults to identify the species: Paracles vulpina (Hübner, [1825]). The current knowledge of immature stages of this species is not useful to identify and discriminate from other species of Paracles. For this reason, we proposed to redescribe adults of P. vulpina, showing for the first time the male and female genitalia, and improve the information on the immature stages and their habits. The adults can be recognized by the whitish paler brown band in the costal area in the forewing and whitish paler brown antenna. The final larval stage of P. vulpina can be differentiated from other species because it shows a body with a black pubescence except for a ferruginous subventral pubescence, blue dorsal verrucae, red lateral verrucae, and dorsal plastron with longest white setae. Because of its polyphagous feeding habit on aquatic and non aquatic plants we consider the aquatic larval habit is not a necessary strategy and could depend on the ground topography or weather of the locality.
Reinstatement of Athis miastagma (Dyar, 1925) (Lepidoptera: Castniidae) as a valid species inhabiting the Pacific slope of Central Mexico
Authors: GONZÁLEZ JORGE M. , LÓPEZ G. BERNARDO , DÍAZ JOSÉ DE JESÚS GARCÍA , SIMON SABRINA , MONTEYS VÍCTOR SARTO I , WORTHY ROBERT
Published: November 2021

Mexico is the Mesoamerican country with the highest number of Castniidae species (12), most of which are found in the dry regions of the country. Among these, Athis hechtiae (Dyar, 1910) was considered a species widely distributed in Mexico after Athis miastagma (Dyar, 1925) was synonymized with A. hechtiae over two decades ago. A genetic and morphological study, as well as details of the natural history of various populations of these two taxa have led us to restore Athis miastagma as a valid species (stat. rest.), increasing the number of castniids recorded in Mexico to 13.
Sex and Prediction Error, Part 3: Provoking Prediction Error
Authors: Dall’Aglio John
Published: November 2021

In parts 1 and 2 of this Lacanian neuropsychoanalytic series, surplus prediction error was presented as a neural correlate of the Lacanian concept of jouissance. Affective consciousness (a key source of prediction error in the brain) impels the work of cognition, the predictive work of explaining what is foreign and surprising. Yet this arousal is the necessary bedrock of all consciousness. Although the brain’s predictive model strives for homeostatic explanation of prediction error, jouissance “drives a hole” in the work of homeostasis. Some residual prediction error always remains. Lacanian clinical technique attends to this surplus and the failed predictions to which this jouissance “sticks.” Rather than striving to eliminate prediction error, clinical practice seeks its metabolization. Analysis targets one’s mode of jouissance to create a space for the subject to enjoy in some other way. This entails working with prediction error, not removing or tolerating it. Analysis aims to shake the very core of the subject by provoking prediction error—this drives clinical change. Brief clinical examples illustrate this view.
Evaluation of the Axillary Surgery Performed in Clinically Node-Positive Breast Cancer Patients Following Neoadjuvant Chemotherapy
Authors: Pearce Jane B. , Hsu Fang-Chi , Howard-McNatt Marissa M. , Levine Edward A. , Chiba Akiko
Published: November 2021

Background

The American College of Surgeons Oncology Group Z1071 trial in 2013 demonstrated the fesability of sentinel lymph node biopsy in clinically node-positive patients following neoadjuvant chemotherapy. The goal of this study was to determine the continued impact of this study on our practice pattern.

Materials and Methods

This is a retrospective review of institutional changes in the management of axillary nodal disease following the publication of Z1071. Patients with clinically node-positive disease that completed neoadjuvant chemotherapy between 2014 and 2020 were included. The Cocoran-Armitage trend test was used to analyze change in categorical variables over time, and the Spearman’s rank coefficient was used to analyze two-ranked variables.

Results

A cohort of 102 patients were included in the study and demonstrated that the number of sentinel lymph node biopsies to evaluate axillary disease increased over time. Additionally, the number of biopsies of suspicious nodes, and the use of marker clips on the biopsied nodes increased over time.

Conclusion

Our institution has continued to incorporate the result from Z1071 in our practice patterns.
From Quantity to Quality: Capturing Higher Spending Markets through a Segmentation of Travelers’ Expenditure
Authors: Rubina Nava Consuelo , Osti Linda , Zoia Maria Grazia
Published: November 2021

Many tourism destinations aim at expanding their market share of high spending visitors by shifting from quantity to quality. The COVID-19 pandemic has forced the introduction of social distancing requiring hotspots and mass destinations to reduce their capacity. This paper proposes a two-step approach for identifying top spending European countries over time, distinguishing between leisure and business travelers. The methodology employs the Country Product Dummy index with a hierarchical clusterization, enriched by a convergence analysis. This approach overcomes general shortcomings of descriptive statistics and cluster analyses directly applied to raw expenditure data. The outcomes of this analysis provide a detailed picture of the European travelers’ expenditure across time and geographical area. The identified top spending countries of leisure and business travelers can be targeted through ad-hoc marketing campaigns and specific packages for privileging quality tourism and planning economic recovery in the post-COVID-19 reopening phase, while shifting away from mass tourism.
Altered amygdala-cortical connectivity in individuals with Cannabis use disorder
Authors: Aloi Joseph , McCusker Marie C , Lew Brandon J , Schantell Mikki , Eastman Jacob A , Frenzel Michaela R , Wilson Tony W
Published: November 2021

Background:

Cannabis is one of the most commonly used substances in the United States. Prior literature using task-based functional magnetic resonance imaging (fMRI) has identified that individuals with Cannabis use disorder (CUD) show impairments in emotion processing circuitry. However, whether the functional networks involving these regions are also altered in CUD remains poorly understood.

Aims:

Investigate changes in resting-state functional connectivity (rsFC) in regions related to emotional processing in CUD.

Methods:

Sixty-two participants completed resting-state fMRI, including 21 with CUD, 20 with histories of illicit substance use but no current CUD diagnosis, and 21 with no history of illicit substance use. Whole-brain seed-based connectivity analyses were performed and one-way analyses of covariance (ANCOVAs) were conducted to detect group differences in the bilateral amygdalae, hippocampi, and the anterior and posterior cingulate cortices.

Results:

The CUD group exhibited significant reductions in rsFC between the amygdala and the cuneus, paracentral lobule, and supplementary motor area, and between the cingulate cortices and the occipital and temporal lobes. There were no significant group differences in hippocampal functional connectivity. In addition, CUD symptom counts based on the Structured Clinical Interview for DSM-5 (SCID) and the Cannabis Use Disorders Identification Test (CUDIT) significantly correlated with multiple connectivity metrics.

Conclusion:

These data expand on emerging literature indicating that CUD is associated with dysfunction in the neural circuits underlying emotion processing. Dysfunction in emotion processing circuits may play a role in the behavioral impairments seen in emotion processing tasks in individuals with CUD, and the severity of CUD symptoms appears to be directly related to the degree of dysfunction in these circuits.
Exact Association Between Preoperative Blood Viscosity and Postoperative Deep Venous Thrombosis Risk in Knee Osteoarthritis Patients: A 10-Year Retrospective Study
Authors: Dai Xiaoyu , Wang Xuan , Huang Zhihui , Wang Kejie , Ding Wenge
Published: November 2021

Several lines of evidence have suggested a sustainable relationship between blood viscosity (BV) and deep vein thrombosis (DVT). But there was a lack of data on the association of preoperative BV and postoperative acute DVT. For patients who accepted total knee arthroplasty (TKA) caused by primary knee osteoarthritis (KOA), this study tried to investigate whether preoperative BV relevant parameters might affect DVT risk following TKA. We reviewed a total of 750 consecutive KOA patients treated by unilateral TKA in our hospital from March 2010 to May 2020. All patients undergoing TKA were routinely examined by the color Doppler ultrasound on the third postoperative day and were assigned into DVT and non-DVT groups. Statistical comparisons of BV relevant parameters which mainly including whole BV (low, midst, and high shear rates), plasma viscosity, whole blood reductive viscosity (BRV; low, midst, and high shear rates) were made comprehensively. It could be found that low whole BRV (low shear rate) before TKA was significantly related to postoperative DVT risk in all patients, especially in female patients after stratifying by gender ( p < .05). Our results implied that low whole BRV might be a remarkable risk factor of DVT in primary KOA patients after TKA. Timely and effective DVT prophylaxis for these patients is much required.
The language of business and the business of language: Exploring hegemonic linguistic performativity in the UK museum sector
Authors: Aroles Jeremy , Hassard John , Hyde Paula
Published: November 2021

Austerity measures and neoliberal policies have deeply affected the UK cultural sector. In particular they have been central to cementing the idea that contemporary cultural institutions should henceforth be regarded as commercial operations. As the language of business and management (B&M language) increasingly frames how organisations of the cultural sector are described, this paper defines the main discursive practices motivating this performative repositioning. Drawing theoretically from the concept of performativity, and building empirically on in-depth interviews with senior staff across the UK museum sector, we argue that the incursion of B&M language has reshaped the ‘reality’ of the sector by materialising new relations. Signally, we advance a concept of performative hegemonic language to describe a range of manifestations of linguistic re-labelling in the world of the museum. Our paper illustrates what happens when an organisation starts to classify activities through B&M language, considering the implications of framing this etymology as transcendent to its cultural counterpart. Relabelling, we contend, re-orients meaning, and this translates into the ascent of what we call the ‘neoliberal museum’. Overall, our paper unpacks the linguistic-material processes underpinning the ideological transformations affecting the cultural sector.
Offline model predictive control approach to micro-slip control in gearshifts of dual clutch transmission
Authors: Wang Xiwen , Lu Tongli
Published: November 2021

Dual clutch transmission can avoid some noise vibration and harshness issues caused by other transmissions with single clutch. And applying micro-slip control on clutches can further improve the gearshift performance of transmission compared to the lock-up control. Considering the real-time characteristic of vehicle control, an offline model predictive controller designed by multi-parameter quadratic programming was creatively applied in dual clutch transmission to obtain both clutch torque at the same time with optimal control algorithm. In this way, while realizing the micro-slip state of the clutches, the fast response speed can be realized through the off-line controller, which makes it more feasible and practical for transmission control. A six degrees of freedom vehicle powertrain system model was built in MATLAB/Simulink to simulate the proposed control algorithm. The simulation results show that the micro-slip control avoid the negative torque compared to the lock-up control, which leads to a smoother shift process. In addition, compared with the proportional–integral–derivative micro-slip controller, the offline model predictive controller can achieve more stable control effects with less output torque fluctuation and shorter gearshift time.
Ageing people with intellectual disabilities and the association between frailty factors and social care: A Swedish national register study
Authors: Ahlström Gerd , Wallén Eva Flygare , Tideman Magnus , Holmgren Marianne
Published: November 2021

The aim of this study was to describe the social care provided for different age groups of people with intellectual disability, 55 years or above, and to investigate the association between such care and frailty factors for those with diagnosed level of intellectual disabilities. Descriptive and logistic regression analyses were used. Commonest forms of social care among the 7936 people were Residential care, Daily activities and Contact person. Home help and Security alarm increased with age. The frailty factors significantly associated with increased social care were age, polypharmacy and severe levels of intellectual disabilities. Persons most likely to be in residential care were in the age group 65–79 with polypharmacy and severe disability. The results indicate a need for further research of how frailty factors are considered in social care and longstanding medication, especially then severe intellectual disability hinders communication. A national strategic plan for preventive interventions should be developed to ensure the best possible healthy ageing.
Being Present 2.0: Online Mindfulness-Based Program for Metastatic Gastrointestinal Cancer Patients and Caregivers
Authors: Dragomanovich Hannah M. , Dhruva Anand , Ekman Eve , Schoenbeck Kelly L. , Kubo Ai , Van Blarigan Erin L. , Borno Hala T. , Esquivel Mikaela , Chee Bryant , Campanella Matthew , Philip Errol J. , Rettger John P. , Rosenthal Blake , Van Loon Katherine , Venook Alan P. , Boscardin Christy , Moran Patricia , Hecht Frederick M. , Atreya Chloe E.
Published: November 2021

Purpose

A metastatic cancer diagnosis is associated with high levels of distress in patients and caregivers, which may be alleviated by mindfulness interventions. Research on scalable, tailored, online mindfulness training programs is needed. We sought to test the feasibility and acceptability of a remotely delivered 8-week mindfulness-based intervention, Being Present 2.0 (BP2.0).

Methods

We performed a single-arm feasibility study of BP2.0 among patients with any metastatic gastrointestinal cancer receiving chemotherapy, with or without an informal caregiver. Participants were instructed to practice mindfulness using pre-recorded guided meditations 5 times per week using a study-specific website and to attend a weekly live, interactive virtual meeting facilitated by a trained instructor. The web-based platform enabled direct measurement of adherence.

Results

The study enrolled 46 of 74 (62%) patients contacted, together with 23 caregivers (69 participants total), from May to October 2018. Median patient age was 52 (range 20-70 years), 39% were male, 67% non-Hispanic white, 65% had colorectal cancer, and 78% lived outside of San Francisco. The top reasons cited for participation were to reduce stress/anxiety and learn how to meditate. Mean baseline National Comprehensive Cancer Network Distress Thermometer (NCCN DT) scores were 4.7 (patients) and 5.8 (caregivers). The study discontinuation rate was 20% (eight patients and six caregivers). Among the remaining 55 participants, 43 (78%) listened to at least one audio recording and/or attended at least one virtual meeting, although adherence data was incomplete. The retention rate was 71%, with 39 participants completing at least one follow-up assessment. In post-intervention qualitative interviews, 88% of respondents reported a positive experience. Compared to baseline, participants reported significantly reduced post-intervention NCCN DT scores (mean 3.1; P = .012).

Conclusion

The BP2.0 online mindfulness-based program is feasible and acceptable for patients with metastatic gastrointestinal cancer and caregivers. These results will guide plans for a follow-up efficacy study. ClinicalTrials.gov Identifier: NCT03528863.
A Cross-National Study of COVID-19 Impact and Future Possibilities Among Emerging Adults: The Mediating Role of Intolerance of Uncertainty
Authors: Lanz Margherita , Sorgente Angela , Vosylis Rimantas , Fonseca Gabriela , Lep Žan , Li Lijun , Zupančič Maja , Crespo Carla , Relvas Ana Paula , Serido Joyce
Published: November 2021

The present research examined the association of perceived impact of COVID-19 on emerging adults’ perceptions of their future and the potential mediating role of intolerance of uncertainty on these associations. Specifically, we investigated the associations of perceived financial impact, needed resource impact, and psychological impact on perceptions of future life and financial future. Using online survey data from emerging adults ( N = 1768) living in six countries (China, Italy, Lithuania, Portugal, Slovenia, and USA), we found that the perceived dimension of impact (i.e., finances, needed resources, and psychological) was negatively associated with perceptions of future life and financial future, despite mean level differences by country. The ability to tolerate uncertainty was a significant mediator only for psychological impact. We conclude the article with suggestions for applying our findings in the design of future interventions.
Osteochondral Lesions of the Tibial Plafond: A Systematic Review
Authors: Butler James J. , Mercer Nathaniel P. , Hurley Eoghan T. , Shimozono Yoshiharu , Kennedy John G.
Published: November 2021

Background:

There is a paucity of data regarding osteochondral lesions of the tibial plafond (OLTPs), in part because they are far less common than osteochondral lesions of the talus.

Purpose:

To evaluate the topographical characteristics of OLTPs and outcomes after surgical intervention, while analyzing the level of evidence (LOE) and quality of evidence (QOE) of the included studies.

Study Design:

Systematic review; Level of evidence, 4.

Methods:

A systematic review of the MEDLINE, EMBASE, and Cochrane Library databases was performed in accordance with PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Studies reporting clinical data for OLTPs were included. The LOE and QOE of the included studies were evaluated using a 5-level grading system and the modified Coleman Methodology Score, respectively.

Results:

Included were 20 studies with 426 OLTPs; 4 studies were LOE 2 and 16 studies were LOE 4. Overall, 86.7% of OLTPs were associated with a traumatic history and/or previous ankle sprain. OLTPs were most commonly located in the centromedial region of the tibial plafond (30.4%), with the fewest number of OLTPs found in the anteromedial region of the tibial plafond (3.9%). In 17 of the studies, a total of 46.9% of OLTPs were associated with coexisting osteochondral lesions of the talus. The most frequently used surgical technique to treat OLTPs was microfracture, which resulted in good clinical outcomes at midterm follow-up.

Conclusion:

The results of this systematic review indicated that OLTPs are frequently preceded by ankle trauma and are often associated with coexisting osteochondral lesions of the talus. Clinical outcomes after arthroscopic intervention appear to produce good results in the midterm, but the low LOE, poor QOE, marked heterogeneity, and underreporting of the data confound any recommendation based on this systematic review.
Nested Contexts of Reception and K–12 Schools: Addressing Immigration Status
Authors: Murillo Marco A. , Quartz Karen Hunter , Garcia Leyda W. , Liboon Christine Abagat
Published: November 2021

Scholarship on the intersection between immigration, legal status, and education has grown over the past decade. Given that schools are intended to be purveyors of democratic values, schools represent an ideal context to examine how immigration and legal status are considered in a community that aims to support the academic and social success of all students This study investigates how members of an urban, K–12 school community in California addressed immigration issues over nearly a decade-long period. The study details three ways in which the school addressed immigration status issues across time. They include college-going supports, addressing newcomer/unaccompanied students’ needs, and delivery of legal services. The study’s implications highlight how K–12 schools can address immigration issues in intentional, ethical, and supportive ways.
Lessons on the Resource-Based View and Generic Competitive Strategies From Kinky Boots: The Musical
Authors: Rhew Nicholas D. , Arendt Lucy A.
Published: November 2021

Kinky Boots: The Musical is a filmed version of the London West End production that tells the story of the unlikely collaboration between Charlie Price, inheritor of a struggling family business, and Lola, a high-energy and creative drag performer, who together radically change Price & Son’s focus from men’s dress shoes to fetish footwear. The musical lends itself well to use in strategic management and organizational behavior courses as a video case or source of video clips. This article explains how strategic management instructors may use the film to discuss sustainable competitive advantage through the resource-based view and generic competitive strategies, while organizational behavior instructors may use the film to illustrate concepts such as managerial roles, diversity, conflict management, and more.
Transposable elements that have recently been mobile in the human genome
Authors: Autio Matias I. , Bin Amin Talal , Perrin Arnaud , Wong Jen Yi , Foo Roger S.-Y. , Prabhakar Shyam
Published: November 2021

Background

Transposable elements (TE) comprise nearly half of the human genome and their insertions have profound effects to human genetic diversification and as well as disease. Despite their abovementioned significance, there is no consensus on the TE subfamilies that remain active in the human genome. In this study, we therefore developed a novel statistical test for recently mobile subfamilies (RMSs), based on patterns of overlap with > 100,000 polymorphic indels.

Results

Our analysis produced a catalogue of 20 high-confidence RMSs, which excludes many false positives in public databases. Intriguingly though, it includes HERV-K, an LTR subfamily previously thought to be extinct. The RMS catalogue is strongly enriched for contributions to germline genetic disorders (P = 1.1e-10), and thus constitutes a valuable resource for diagnosing disorders of unknown aetiology using targeted TE-insertion screens. Remarkably, RMSs are also highly enriched for somatic insertions in diverse cancers (P = 2.8e-17), thus indicating strong correlations between germline and somatic TE mobility. Using CRISPR/Cas9 deletion, we show that an RMS-derived polymorphic TE insertion increased the expression of RPL17, a gene associated with lower survival in liver cancer. More broadly, polymorphic TE insertions from RMSs were enriched near genes with allele-specific expression, suggesting widespread effects on gene regulation.

Conclusions

By using a novel statistical test we have defined a catalogue of 20 recently mobile transposable element subfamilies. We illustrate the gene regulatory potential of RMS-derived polymorphic TE insertions, using CRISPR/Cas9 deletion in vitro on a specific candidate, as well as by genome wide analysis of allele-specific expression. Our study presents novel insights into TE mobility and regulatory potential and provides a key resource for human disease genetics and population history studies.
Combined effect of daily physical activity and social relationships on sleep disorder among older adults: cross-sectional and longitudinal study based on data from the Kasama study
Authors: Seol Jaehoon , Lee Jaehee , Nagata Koki , Fujii Yuya , Joho Kaya , Tateoka Korin , Inoue Taiki , Liu Jue , Okura Tomohiro
Published: November 2021

Background

This study investigated whether daily physical activity of older adults, combined with social relationships, is associated with the risk of sleep disorder. Further, it determined whether a high level of one variable with a low level of the other, leads to a significantly lower risk of sleep disorder than low levels of both.

Methods

The sample comprised 1339 community-dwelling older Japanese adults: 988 in Study 1 and 351 in Study 2. The level of daily physical activity and range of social relationships were assessed using the Physical Activity Scale for the Elderly and the Lubben Social Network Scale, respectively. The Pittsburgh Sleep Quality Index was used to assess sleep disorder. To test the combined relationships and effects in Studies 1 and 2, the medians for the respective scores of each of the following four groups that the participants were categorized into, were calculated: (1) low activity group with low social relationships, (2) low activity group with high social relationships, (3) high activity group with low social relationships, and (4) high activity group with high social relationships. After adjusting for potential confounders, a logistic regression analysis was conducted in Study 1. After adjusting for potential confounders, a Cox proportional hazards regression analysis was conducted in Study 2.

Results

Study 1 revealed that the high activity group with high social relationships showed a significantly lower risk of sleep disorder (ORs: 0.585, 95% CI: 0.404–0.847) than the low activity group with low social relationships. Study 2 also revealed that the high activity group with high social relationships showed a significantly lower prevalence of sleep disorder (HRs: 0.564, 95% CI: 0.327–0.974) than the low activity group with low social relationships.

Conclusions

Our findings suggest that for older adults with high social relationships, being physically active is favorably associated with sleep quality. However, a high level of one variable with a low level of the other has not been confirmed in improving sleep quality among older adults.