bluuebunny/crossref_metadata_2025 huggingface dataset:
Minimal Clinically Important Difference (MCID) in the Functional Status Measures in Patients with Stroke: Inverse Probability Treatment Weighting
Authors: Chang Yu-Chien , Lin Hsiu-Fen , Chen Yu-Fu , Chen Hong-Yaw , Shiu Yu-Tsz , Shi Hon-Yi
Published: September 2023

This study proposed to evaluate the temporal trend, define the minimal clinically important difference (MCID) for five functional status measures, and identify risk factors for reaching deterioration in the MCID. This prospective cohort study analyzed 680 patients with ischemic stroke and 151 patients with hemorrhagic stroke at six hospitals between April 2015 and October 2021. All patients completed the functional status measures before rehabilitation (baseline), and at the 12th week and 2nd year after rehabilitation. Patients in the post-acute care (PAC) group exhibited significantly larger improvements for the functional status measures compared to those in the non-PAC group (p < 0.05). Patients with hemorrhagic stroke also displayed larger improvements in the functional status measures when compared to patients with ischemic stroke. Furthermore, the improvement in MCID ranged from 0.01 to 16.18 points when comparing baseline and the 12th week after rehabilitation, but the deterioration in MCID ranged from 0.38 to 16.12 points. Simultaneously, assessing the baseline and the second year after rehabilitation, the improvement in MCID ranged from 0.01 to 18.43 points, but the deterioration in MCID ranged from 0.68 to 17.26 points. Additionally, the PAC program, age, education level, body mass index, smoking, readmission within 30 days, baseline functional status score, use of Foley catheter and nasogastric tube, as well as a history of previous stroke are significantly associated with achieving deterioration in MCID (p < 0.05). These findings suggest that if the mean change scores of the functional status measures have reached the thresholds, the change scores can be perceived by patients as clinically important.
Heavy Metals in Sediments of Subarctic Meromictic Lakes of the White Sea as Possible Tracers of Environmental Changes
Authors: Budko Dmitry F. , Demina Liudmila L. , Krasnova Elena D. , Starodymova Dina P.
Published: September 2023

Meromictic lakes of the marine coast, quite widely distributed in the northern hemisphere, are the result of climate changes and glacier retreat. The bottom sediments of these lakes serve as a geological chronicle of the history of marine basin’s development with the geochemical occurrence forms of elements indicate various processes of their accumulation. This paper presents research results concerning the occurrence of forms of heavy metals in lake sediments along the coast of the White Sea. These results are based on a sequential seven step leaching procedure, followed by ICP-MS analysis and subsequent statistical data processing. To determine differences among the examined geochemical parameters, Pearson’s correlation analysis and Ward’s cluster analysis were utilized. The total content of Cr, Mn, Fe, Co, Ni, Zn, V, and Pb in the sediments did not exhibit significant differences based on their degree of isolation from the sea. The major contribution to deposition of these metals in sediments of the meromictic lakes studied is the residual form, encompassing the mineral matrix of the sediment. At the same time, the elevation of mobile forms for all the metals examined corresponds to an increase in the isolation of lakes from the White Sea. In the meromictic lake sediments, concentrations of Cu, Mo, and U demonstrated significant increases in forms tightly bound to organic matter, while Cd exhibited an association with Fe-Mn oxyhydroxides. Notably, a significant difference in the occurrence forms of Cu, Cd, Mo, and U was evident in the reduced sediments of meromictic lakes when compared to those of open sea bays. The meromictic lakes along the White Sea coast, positioned at various stages of isolation, hold promise for investigating the migration of metals in response to environmental changes.
Biological and Management-Related Predictors of Reproductive Success in North American Ex Situ Asian Small-Clawed Otters (Aonyx cinereus)
Authors: Franklin Ashley D. , McDonald Monica M. , Agnew Mary , Duncan Sarah , Powell David M.
Published: September 2023

The long-term sustainability of ex situ animal populations requires coordination across facilities through cooperative breeding programs. Here, we investigate the reasons for inconsistent reproductive success in the zoo-based North American Asian small-clawed otter (ASCO; Aonyx cinereus) population. Reproductive viability analysis (RVA) was used to identify which characteristics of ASCOs in breeding pairs were most predictive of reproductive success. The RVA identified pair type, contraception history, and age as the most significant predictors of offspring production. The use of deslorelin in males and long-term deslorelin use in females hinder future reproductive potential and should, therefore, be considered carefully in genetically valuable individuals and potential breeders. Moreover, genetically valuable animals should be paired with younger mates, as advancing male and female age decreases the likelihood of success. The lack of reproductive success observed after 1 year of attempted breeding among new pairs provides evidence of potential mate incompatibility, therefore, population managers should consider splitting up pairs that remain unsuccessful over time, because the likelihood of offspring production is low. Lastly, the inclusion of dens and/or caves and pools designed with ample shallow water areas in ASCO habitats may improve breeding success.
Enabling In-Situ Urbanization through Digitalization
Authors: Li Le , Song Tao
Published: September 2023

The bourgeoning of e-commerce in the context of the information era has accelerated the urbanization trend by broaching a new horizon of economic and industrial boosters for rural places, epitomized by a great number of “Taobao Villages” in China. This paper has two objectives: (1) explore the process and mechanism of digitalization enabling rural in-situ urbanization represented by e-commerce; (2) nuance the specific case evidence of Daiji Town, where digitalization enabled in-situ urbanization recently. We build up a theoretical framework for digitalization-enabled in-situ urbanization from the juxtaposition of four interlinked elements: industry, talent, rural governance, and land use. It then analyzed the details and evidence of digitalization enabling rural in-situ urbanization through the case study of Daiji Town. The main conclusions of this paper are as follows: First, digitalization plugs rural areas into production and consumption networks in wider contexts, promoting the transformation and prosperity of rural economies. Secondly, the reverse migration of young generations to rural areas becomes the key to rural in-situ urbanization. Thirdly, digitization materializes the urbanization of rural spaces. Finally, digitalization enables the rural transformation and improvement of urban-rural relations in the Global South, which needs to be further explored.
Experimental Investigation on the Effect of Velocity Anisotropy on Oil Film State under Different Surface Wettability Interface
Authors: Wang Zuomin , Zhang Jianjun , Wang Shijin , Wang Weihui , Che Qinglun
Published: September 2023

This study focuses on the utilization of surface modification technology to create glass disks with varying surface wettability. A measurement test bench for point contact lubrication film is employed to investigate the impact of changes in the angle between the velocities of the glass disk and steel ball on the state of the lubricating oil film at the interface. The results show that altering the surface wettability reduces the adhesive strength between the interface and the adjacent lubricant, leading to a decrease in the ultimate shear stress, and inducing interface slippage. When the rotational velocity of the disk matches the translational velocity of the ball and their trajectories are inclined at specific angles, the sliding velocity increases proportionally to the inclination angle, which contributes significantly to the thermal effect. Furthermore, when the velocity varies across the interface with differences in wettability, the contact zone forms a wedge-shaped gap and causes modifications in the oil film’s shape, including the formation of an inlet dimple and an inclined straight stripe. The dominant factor influencing the interface is the slip when the angle is acute, whereas the thermal effect plays a significant role when the angle is obtuse. This work is expected to provide a new strategy for elastohydrodynamic lubrication under surface wettability interfaces.
A Comprehensive Review of Emerging Trends in Aircraft Structural Prognostics and Health Management
Authors: Khalid Salman , Song Jinwoo , Azad Muhammad Muzammil , Elahi Muhammad Umar , Lee Jaehun , Jo Soo-Ho , Kim Heung Soo
Published: September 2023

This review paper addresses the critical need for structural prognostics and health management (SPHM) in aircraft maintenance, highlighting its role in identifying potential structural issues and proactively managing aircraft health. With a comprehensive assessment of various SPHM techniques, the paper contributes by comparing traditional and modern approaches, evaluating their limitations, and showcasing advancements in data-driven and model-based methodologies. It explores the implementation of machine learning and deep learning algorithms, emphasizing their effectiveness in improving prognostic capabilities. Furthermore, it explores model-based approaches, including finite element analysis and damage mechanics, illuminating their potential in the diagnosis and prediction of structural health issues. The impact of digital twin technology in SPHM is also examined, presenting real-life case studies that demonstrate its practical implications and benefits. Overall, this review paper will inform and guide researchers, engineers, and maintenance professionals in developing effective strategies to ensure aircraft safety and structural integrity.
Expanding the Minimally Invasive Approach towards the Ascending Aorta—A Practical Overview of the Currently Available Techniques
Authors: Helms Florian , Schmack Bastian , Weymann Alexander , Hanke Jasmin Sarah , Natanov Ruslan , Martens Andreas , Ruhparwar Arjang , Popov Aron-Frederik
Published: September 2023

Minimally invasive techniques have gained immense importance in cardiovascular surgery. While minimal access strategies for coronary and mitral valve surgery are already widely accepted and often used as standard approaches, the application of minimally invasive techniques is currently expanded towards more complex operations of the ascending aorta as well. In this new and developing field, various techniques have been established and reported ranging from upper hemisternotomy approaches, which allow even extensive operations of the ascending aorta to be performed through a minimally invasive access to sternal sparing thoracotomy strategies, which completely avoid sternal trauma during ascending aorta replacements. All of these techniques place high demands on patient selection, preoperative planning, and practical surgical implementation. Application of these strategies is currently limited to high-volume centers and highly experienced surgeons. This narrative review gives an overview of the currently available techniques with a special focus on the practical execution as well as the advantages and disadvantages of the currently available techniques. The first results demonstrate the practicability and safety of minimally invasive techniques for replacement of the ascending aorta in a well-selected patient population. With success and complication rates comparable to classic full sternotomy, the proof of concept for minimally invasive replacement of the ascending aorta is now achieved.
Women’s Leadership and COVID-19 Pandemic: Navigating Crises through the Application of Connective Leadership
Authors: Cartwright Chris T. , Harrington Maura , Orr Sarah Smith , Sutton Tessa
Published: September 2023

International and national crises often highlight behavioral patterns in the labor market that illustrate women’s courage and adaptability in challenging times. The COVID-19 pandemic and resulting changes in the workplace due to social distancing, remote work, and tele-communications protocols showcased women’s power of authenticity and accessibility (interpersonal and personalized experiences) to engage with their constituents effectively. The catalyzed this research was our desire to underscore the importance of studying the impact of COVID-19 on women leaders. The COVID-19 pandemic brought to light specific challenges and disparities women faced in the workplace. It has been asserted that women leaders substantially benefit businesses and organizations and we wanted to test this out through the practices of our research participants. Decades of research reveal that women leaders enhance productivity, foster collaboration, inspire dedication, and promote fairness in the workplace. This article introduces the feminist Connective Leadership Model (CL) an integrative leadership model and one informed by early feminist theory for understanding women’s leadership during the COVID-19 pandemic. A mixed-method study of select US women leaders before and during the COVID-19 pandemic revealed the CL model and its efficacy for adaptive, inclusive leadership in various contexts. First, this article highlights the impact of the COVID-19 pandemic on women’s leadership and behavioral response to the crisis through the lens of the CL model. Second, this article delves into challenges the women leaders faced, including adaptive challenges, isolation, team management, increased caregiving responsibilities, and gender-related disparities. Third, this article reframes women’s voices articulated through a crisis management leadership framework coupled with an understanding and application of the behaviors defined through complexity theory which are aligned with the CL model. Finally, the article discusses the four ‘As’ of crisis leadership: authenticity, alignment, awareness, and adaptability. The application of the CL model provides an effective framework for determining the most appropriate leadership behaviors within the complex challenges of a crisis; it enables the leader to focus on personal, employee, and organizational well-being.
Metabolomic Reconfiguration in Primed Barley (Hordeum vulgare) Plants in Response to Pyrenophora teres f. teres Infection
Authors: Hamany Djande Claude Y. , Tugizimana Fidele , Steenkamp Paul A. , Piater Lizelle A. , Dubery Ian A.
Published: September 2023

Necrotrophic fungi affect a wide range of plants and cause significant crop losses. For the activation of multi-layered innate immune defences, plants can be primed or pre-conditioned to rapidly and more efficiently counteract this pathogen. Untargeted and targeted metabolomics analyses were applied to elucidate the biochemical processes involved in the response of 3,5-dichloroanthranilic acid (3,5-DCAA) primed barley plants to Pyrenophora teres f. teres (Ptt). A susceptible barley cultivar (‘Hessekwa’) at the third leaf growth stage was treated with 3,5-DCAA 24 h prior to infection using a Ptt conidia suspension. The infection was monitored over 2, 4, and 6 days post-inoculation. For untargeted studies, ultra-high performance liquid chromatography coupled with high-resolution mass spectrometry (UHPLC–MS) was used to analyse methanolic plant extracts. Acquired data were processed to generate the data matrices utilised in chemometric modelling and multi-dimensional data mining. For targeted studies, selected metabolites from the amino acids, phenolic acids, and alkaloids classes were quantified using multiple reaction monitoring (MRM) mass spectrometry. 3,5-DCAA was effective as a priming agent in delaying the onset and intensity of symptoms but could not prevent the progression of the disease. Unsupervised learning methods revealed clear differences between the sample extracts from the control plants and the infected plants. Both orthogonal projection to latent structure-discriminant analysis (OPLS-DA) and ‘shared and unique structures’ (SUS) plots allowed for the extraction of potential markers of the primed and naïve plant responses to Ptt. These include classes of organic acids, fatty acids, amino acids, phenolic acids, and derivatives and flavonoids. Among these, 5-oxo-proline and citric acid were notable as priming response-related metabolites. Metabolites from the tricarboxylic acid pathway were only discriminant in the primed plant infected with Ptt. Furthermore, the quantification of targeted metabolites revealed that hydroxycinnamic acids were significantly more prominent in the primed infected plants, especially at 2 d.p.i. Our research advances efforts to better understand regulated and reprogrammed metabolic responses that constitute defence priming in barley against Ptt.
Research on Pachymaran to Ameliorate CsA-Induced Immunosuppressive Lung Injury by Regulating Microflora Metabolism
Authors: Ye Chun , Gao Zi-Han , Chen Kai-Qin , Lu Fang-Guo , Wei Ke
Published: September 2023

Pachymaran (PCP), the major medicinal constituent of Poria cocos, has a regulatory effect on immunosuppressive lung injury, but its mechanism of action with respect to gut microorganisms and their metabolites is not clear. The aim of this study was to investigate the protective effect of PCP against immunosuppressive lung injury caused by cyclosporine A (CsA), and to reveal its possible mechanism of action via the comprehensive analysis of 16S rRNA and LC-MS. We demonstrated that PCP was effective at alleviating CsA-induced immunosuppressive lung injury by restoring the organ indices and lung tissue morphology and structure. PCP significantly altered the composition of the gut and lung microbiota in mice with CsA-induced immunosuppressive lung injury by increasing the number of beneficial bacteria from the Eubacterium nodatum group, Eubacterium ventriosum group, Akkermansia, and Ruminococcus, and reducing the pathogenic Rikenellaceae RC9 gut group to fulfill its immunomodulatory role. In lung tissue microecology, PCP intervention significantly reduced the abundance of Chryseobacterium, Lawsonella, Paracoccus, and Sediminibacterium and increased the abundance of Alloprevotella. The LC-MS results showed that PCP alleviated the CsA-induced immunosuppression of lung tissue injury. The model serum metabolite Americine decreased the expression of PC(O-18:1(4Z)/0:0). Our results suggest that PCP may be involved in regulating the composition, function, and metabolism of the gut and lung microbiota to reverse CsA-induced immunosuppressive lung injury.
Development Features of Ixodes ricinus × I. persulcatus Hybrids under Laboratory Conditions
Authors: Belova Oxana A. , Polienko Alexandra E. , Averianova Anastasia D. , Karganova Galina G.
Published: September 2023

Widely distributed Ixodes ricinus and Ixodes persulcatus ticks transmit many pathogens of both medical and veterinary significance. The ranges of these tick species overlap and form large sympatric areas in the East European Plain and Baltic countries. It has previously been shown that crossing I. ricinus and I. persulcatus is possible, resulting in the appearance of sterile hybrids. In the present study, we analyzed the features of this hybrid’s life cycle under laboratory conditions. For this purpose, virgin females of I. ricinus and I. persulcatus ticks were obtained in the laboratory, and hybrid generations of ticks were bred from the reciprocal crossings of these two tick species. According to our data, mating the females of I. ricinus and I. persulcatus with the males of another species leads to a decrease in the engorgement success of the females, a decrease in the number of hatched larvae, and the appearance of a hybrid generation in which both females and males are sterile. Under laboratory conditions at a constant room temperature and under natural daylight, the morphogenetic diapause of the engorged I. persulcatus larvae began in September. For I. persulcatus nymphs, it occurred earlier than for I. ricinus, in October and November, respectively. The hybrids generally repeated the features of the life cycle of the mother species.
Lee–Yang Zeroes in the Baryon Fugacity Plane: The Role of High Densities
Authors: Gerasimeniuk Nikolai , Bornyakov Vitaly , Goy Vladimir , Rogalyov Roman , Korneev Anatolii , Molochkov Alexander , Nakamura Atsushi
Published: September 2023

We compute the canonical partition functions and the Lee–Yang zeros in Nf=2 lattice QCD at temperature T=1.20Tc lying above the Roberge–Weiss phase transition temperature TRW. The phase transition is characterized by the discontinuities in the baryon number density at specific values of imaginary baryon chemical potential. We further develop our method to compute the canonical partition functions using the asymptotic expression for respective integral. Then, we compute the Lee–Yang zeros and study their behavior in the limit of high baryon density.
Interferon-λ Activates a Differential Response in Peripheral Neurons That Is Effective against Alpha Herpesvirus Infections
Authors: Salazar Stephanie , Luong Khanh T. Y. , Nua Taulima , Koyuncu Orkide O.
Published: September 2023

Alpha herpesviruses (α-HV) infect host mucosal epithelial cells prior to establishing a life-long latent infection in the peripheral nervous system. The initial spread of viral particles from mucosa to the nervous system and the role of intrinsic immune responses at this barrier is not well understood. Using primary neurons cultured in compartmentalized chambers, prior studies performed on Pseudorabies virus (PRV) have demonstrated that type I and type II interferons (IFNs) induce a local antiviral response in axons via distinct mechanisms leading to a reduction in viral particle transport to the neuronal nucleus. A new class of interferons known as type III IFNs has been shown to play an immediate role against viral infection in mucosal epithelial cells. However, the antiviral effects of type III IFNs within neurons during α-HV infection are largely unknown. In this study, we focused on elucidating the antiviral activity of type III IFN against PRV neuronal infection, and we compared the interferon-stimulated gene (ISGs) induction pattern in neurons to non-neuronal cells. We found that IFN pre-exposure of both primary neurons and fibroblast cells significantly reduces PRV virus yield, albeit by differential STAT activation and ISG induction patterns. Notably, we observed that type III IFNs trigger the expression of a subset of ISGs mainly through STAT1 activation to induce an antiviral state in primary peripheral neurons.
Epigenetic Control of Plant Response to Heavy Metals
Authors: Fasani Elisa , Giannelli Gianluigi , Varotto Serena , Visioli Giovanna , Bellin Diana , Furini Antonella , DalCorso Giovanni
Published: September 2023

Plants are sessile organisms that must adapt to environmental conditions, such as soil characteristics, by adjusting their development during their entire life cycle. In case of low-distance seed dispersal, the new generations are challenged with the same abiotic stress encountered by the parents. Epigenetic modification is an effective option that allows plants to face an environmental constraint and to share the same adaptative strategy with their progeny through transgenerational inheritance. This is the topic of the presented review that reports the scientific progress, up to date, gained in unravelling the epigenetic response of plants to soil contamination by heavy metals and metalloids, collectively known as potentially toxic elements. The effect of the microbial community inhabiting the rhizosphere is also considered, as the evidence of a transgenerational transfer of the epigenetic status that contributes to the activation in plants of response mechanisms to soil pollution.
Selection of Reference Genes in Evodia rutaecarpa var. officinalis and Expression Patterns of Genes Involved in Its Limonin Biosynthesis
Authors: Zhou Yu , Zhang Yuxiang , Mu Detian , Lu Ying , Chen Wenqiang , Zhang Yao , Zhang Ruiying , Qin Ya , Yuan Jianhua , Pan Limei , Tang Qi
Published: September 2023

E. rutaecarpa var. officinalis is a traditional Chinese medicinal plant known for its therapeutic effects, which encompass the promotion of digestion, the dispelling of cold, the alleviation of pain, and the exhibition of anti-inflammatory and antibacterial properties. The principal active component of this plant, limonin, is a potent triterpene compound with notable pharmacological activities. Despite its significance, the complete biosynthesis pathway of limonin in E. rutaecarpa var. officinalis remains incompletely understood, and the underlying molecular mechanisms remain unexplored. The main purpose of this study was to screen the reference genes suitable for expression analysis in E. rutaecarpa var. officinalis, calculate the expression patterns of the genes in the limonin biosynthesis pathway, and identify the relevant enzyme genes related to limonin biosynthesis. The reference genes play a pivotal role in establishing reliable reference standards for normalizing the gene expression data, thereby ensuring precision and credibility in the biological research outcomes. In order to identify the optimal reference genes and gene expression patterns across the diverse tissues (e.g., roots, stems, leaves, and flower buds) and developmental stages (i.e., 17 July, 24 August, 1 September, and 24 October) of E. rutaecarpa var. officinalis, LC-MS was used to analyze the limonin contents in distinct tissue samples and developmental stages, and qRT-PCR technology was employed to investigate the expression patterns of the ten reference genes and eighteen genes involved in limonin biosynthesis. Utilizing a comprehensive analysis that integrated three software tools (GeNorm ver. 3.5, NormFinder ver. 0.953 and BestKeeper ver. 1.0) and Delta Ct method alongside the RefFinder website, the best reference genes were selected. Through the research, we determined that Act1 and UBQ served as the preferred reference genes for normalizing gene expression during various fruit developmental stages, while Act1 and His3 were optimal for different tissues. Using Act1 and UBQ as the reference genes, and based on the different fruit developmental stages, qRT-PCR analysis was performed on the pathway genes selected from the “full-length transcriptome + expression profile + metabolome” data in the limonin biosynthesis pathway of E. rutaecarpa var. officinalis. The findings indicated that there were consistent expression patterns of HMGCR, SQE, and CYP450 with fluctuations in the limonin contents, suggesting their potential involvement in the limonin biosynthesis of E. rutaecarpa var. officinalis. This study lays the foundation for further research on the metabolic pathway of limonin in E. rutaecarpa var. officinalis and provides reliable reference genes for other researchers to use for conducting expression analyses.
Genome-Wide Identification and Analysis of TCP Gene Family among Three Dendrobium Species
Authors: Li Yaoting , Li Lingli , Yang Jiapeng , Niu Zhitao , Liu Wei , Lin Yi , Xue Qingyun , Ding Xiaoyu
Published: September 2023

Dendrobium orchids, which are among the most well-known species of orchids, are appreciated for their aesthetic appeal across the globe. Furthermore, due to their strict living conditions, they have accumulated high levels of active ingredients, resulting not only in their medicinal value but also in their strong ability to respond to harsh environments. The TCP gene family plays an important role in plant growth and development, and signal transduction. However, these genes have not been systematically investigated in Dendrobium species. In this study, we detected a total of 24, 23, and 14 candidate TCP members in the genome sequences of D. officinale, D. nobile, and D. chrysotoxum, respectively. These genes were classified into three clades on the basis of a phylogenetic analysis. The TCP gene numbers among Dendrobium species were still highly variable due to the independent loss of genes in the CIN clade. However, only three gene duplication events were detected, with only one tandem duplication event (DcTCP9/DcTCP10) in D. chrysotoxum and two pairs of paralogous DoTCP gene duplication events (DoTCP1/DoTCP23 and DoTCP16/DoTCP24) in D. officinale. A total of 25 cis-acting elements of TCPs related to hormone/stress and light responses were detected. Among them, the proportions of hormone response, light response, and stress response elements in D. officinale (100/421, 127/421, and 171/421) were similar to those in D. nobile (83/352, 87/352, and 161/352). Using qRT-PCR to determine their expression patterns under MeJA treatment, four DoTCPs (DoTCP2, DoTCP4, DoTCP6, and DoTCP14) were significantly upregulated under MeJA treatment, which indicates that TCP genes may play important roles in responding to stress. Under ABA treatment, seven DoTCPs (DoTCP3, DoTCP7, DoTCP9, DoTCP11, DoTCP14, DoTCP15, and DoTCP21) were significantly upregulated, indicating that TCP genes may also play an important role in hormone response. Therefore, these results can provide useful information for studying the evolution and function of TCP genes in Dendrobium species.
Biodegradable Mulching Film vs. Traditional Polyethylene: Effects on Yield and Quality of San Marzano Tomato Fruits
Authors: Di Mola Ida , Cozzolino Eugenio , Ottaiano Lucia , Riccardi Riccardo , Spigno Patrizia , Petriccione Milena , Fiorentino Nunzio , Fagnano Massimo , Mori Mauro
Published: September 2023

Mulching is a common practice for improving crop yield and obtaining an out-of-season production, but when made using plastic materials it can bring environmental problems due to the management and the disposal of films at the end of the cropping seasons. To increase the sustainability of this practice, recently, mulching films made with biodegradable organic materials have become more widely used. Our aim was to evaluate the effect of a biodegradable mulching film on yield and qualitative traits of the San Marzano tomato fruits over two years (2014 and 2015). Two different types of mulching were tested: (i) black biodegradable film (MB12) and (ii) black low-density polyethylene (LDPE) were compared to bare soil (BS). Both mulching films elicited a 25% increase in yield, mainly due to the significantly higher number of fruits per square meter, compared to BS. Both mulching films also elicited a 9.9% increase in total soluble solids and a 57% increase in carotenoid content, while firmness showed the highest value in BS fruits. MB12 determined the highest value of the Hunter color ratio a/b of tomato fruits, followed by LDPE, while the lowest value was recorded in BS fruits. Both mulching films elicited an increase of 9.6%, 26.0%, and 11.7% for flavonoids, polyphenols, and AsA, respectively. In 2014, the MB12 degradation started at 71 days after transplant (DAT); in 2015, at 104 DAT. Therefore, replacing polyethylene with biodegradable film would seem to be an agronomically efficient and environmentally sustainable practice.
The Kingdom by Emmanuel Carrère: Believing or Learning as a Theological Virtue
Authors: Koet Bart J.
Published: September 2023

Le Royaume [English Translation: The Kingdom] is one of the French author Emmanuel Carrère’s most successful works. The main question posed by this book is this: how can normal, intelligent people believe in something as absurd as the Christian religion? One of the believers with whom the author enters into dialogue is Carrère, who for some years was a devout Catholic himself. He then links this questioning to a form of historical research into the sources of Christianity. If Carrère’s historical research is not always up to date, the part devoted to introspection is a convincing testimony, showing how a renowned author grapples with his own past and that of the church in a postmodern, secular world. The interesting aspect of his research is that he finds that, although he is not a believer, he wants to be a disciple.
How Do Extreme Lake Water Temperatures in Poland Respond to Climate Change?
Authors: Olowoyeye Temidayo , Ptak Mariusz , Sojka Mariusz
Published: September 2023

Lakes are vital components of the Earth’s hydrological cycle and are susceptible to the impacts of climate change. Understanding the changes in terms of minimum and maximum lake surface temperatures is crucial for assessing the effects of climate change on freshwater ecosystems. This study focuses on ten lakes in Poland to investigate the impacts of climate change on lake temperatures in different geographical regions. The Mann–Kendall (MK) and Sen tests were employed to analyze trends and changes in minimum and maximum water temperatures, respectively. The results reveal significant increases in the minimum and maximum temperatures, particularly in May and June. Different lakes exhibit varying trends and variability in temperature changes over time, indicating the vulnerability of these ecosystems. The current study also examines the magnitude of annual temperature changes and classifies them into different levels. This analysis highlights the complex relationship between air temperature, seasonal cycles, and lake morphometric characteristics in shaping variations in lake surface water temperature. These findings contribute to understanding the impacts of climate change on Poland’s lakes and provide valuable insights for developing conservation strategies and adaptive measures to protect freshwater resources.
An In-Depth Stability Study of the Essential Oils from Mentha × piperita, Mentha spicata, Origanum vulgare, and Thymus vulgaris: The Impact of Thermal and Storage Conditions
Authors: Ganosi Eugenia , Barda Christina , Grafakou Maria-Eleni , Rallis Michael Ch. , Skaltsa Helen
Published: September 2023

In recent years, there has been a growing scientific interest in essential oils due to their therapeutic and aromatic properties and as potential alternative natural additives for use as preservatives or antibiotics. However, the literature lacks a comprehensive understanding of their stability and how their composition and properties change over time under various conditions. Through this paper, we aim to enhance the existing literature by providing deeper insights into the stability of essential oils and the sustainability of chemical composition in a time-based approach under various conditions. Therefore, four essential oils of the Lamiaceae family (Origanum vulgare, Thymus vulgaris, Mentha spicata, and M. x piperita) were evaluated with respect to their chemical variation influenced by several factors, such as thermal and storage conditions. Three types of containers were utilized to store the essential oils, i.e., glass ampoules, glass tubes, and metallic containers with plastic caps, for up to six months in −20 °C, 4 °C, 23 °C (with or without light exposure), 35 °C, and 45 °C. Samples were routinely analyzed by GC-MS and components were subjected to principal component analysis to ascertain whether the identified constituents may be useful in reflecting the stability of the analyzed samples. The main compounds appeared to be more stable, while the degradation of minor constituents (<1.0%) occurred in all four essential oils despite the storage conditions. Overall, apart from a slight variation in the chemical load, essential oils can be considered stable for various applications, especially those stored under low oxygen availability conditions.
Assessment Tools Measuring Fundamental Movement Skills of Primary School Children: A Narrative Review in Methodological Perspective
Authors: Nagy Ágnes Virág , Wilhelm Márta , Domokos Mihály , Győri Ferenc , Berki Tamás
Published: September 2023

This paper aimed to analyze fundamental movement skill (FMS) assessment tools that could be used for primary school children. In this narrative review, the Motoriktest für Vier- bis Sechjärige Kinder (MOT 4–6), Movement Assessment Battery for Children-2 (M-ABC-2), Motorische Basiskompetenzen (MOBAK) Körperkoordinationtest für Kinder (KTK), Test of Gross Motor Development (TGMD), Maastricht Motoriek Test (MMT) and the Bruininks–Oseretsky Test of Motor Proficiency-2 (BOT-2) were analyzed from a methodological perspective, such as the number of test items, tools and types of tests, in terms of the FMS area. The analysis revealed that to assess locomotor movement skills, the BOT-2 has an excellent test for running ability, but for detecting technical difficulties, the TGMD is recommended. To test hopping, the MMT is the best test. Object control movement skills are measured with throws, dribbles and catches. Most of the tools assessed these skills, but it turned out that the TGMD is the best for measuring object control. Stability movement skills are tested with static and dynamic balance tests. Dynamic balance is more frequently used, and the MOT 4–6, KTK and BOT-2 have the most tools to use. However, the MMT is an excellent test for static balance. Fine motor movement skills are easy to assess with the MMT and MOT 4–6, since they have low equipment requirements. The BOT-2 is the best measurement tool; however, it has high equipment requirements. All of the FMS assessment tools are good; however, we concluded that although these tools are excellent for research purposes, they are difficult to apply in a school setting. Thus, teachers and coaches are advised to always select a single task from the available assessment tools that is appropriate for the skills they would like to measure.
Study on Dihydromyricetin Improving Aflatoxin Induced Liver Injury Based on Network Pharmacology and Molecular Docking
Authors: Zhu Xiaoying , Liu Silu , Pei Hongyan , Chen Weijia , Zong Ying , Zhao Yan , Li Jianming , Du Rui , He Zhongmei
Published: September 2023

Aflatoxin B1 (AFB1) is a toxic food/feed contaminant and the liver is its main target organ, thus it poses a great danger to organisms. Dihydromyricetin (DHM), a natural flavonoid compound, can be used as a food additive with high safety and has been shown to have strong hepatoprotective effects. In this experiment, PPI network and KEGG pathway analysis were constructed by network pharmacological analysis technique using software and platforms such as Swiss, String, and David and Cytoscape. We screened AFB1 and DHM cross-targets and pathways of action, followed by molecular docking based on the strength of binding affinity of genes to DHM. In addition, we exposed AFB1 (200 μg/kg) to mice to establish a liver injury model. Histological observation, biochemical assay, oxidative stress indicator assay, TUNEL staining and Western blot were used to evaluate the liver injury. Network pharmacological results were screened to obtain 25 cross-targets of action and 20 pathways of action. It was found that DHM may exert anti-hepatic injury effects by inhibiting the overexpression of Caspase-3 protein and increasing the expression of Bcl-2 protein. DHM (200 mg/kg) was found to reduce AFB1-induced liver indices such as alanine aminotransferase (ALT) and aspartate acyltransferase (AST), and attenuate hepatic histopathological damage through animal models. Importantly, DHM inhibited malondialdehyde (MDA) formation in liver tissue and attenuated AFB1-induced oxidative stress injury by increasing glutathione-S-transferase (GST) glutathione (GPX) catalase (CAT) and superoxide dismutase (SOD). Meanwhile, DHM also restored the expression of anti-apoptotic protein Bcl-2 and antioxidant proteins, Nrf2, Keap1 and its downstream HO-1, and down-regulated the expression of pro-apoptotic proteins Bax and Caspase-3 in AFB1-induced liver tissues. The results confirmed that liver injury caused by AFB1 exposure could be alleviated by DHM, providing valuable guidance for in-depth study of DHM in the treatment of liver-related diseases, and laying the foundation for in-depth development and utilization of DHM.
Factors Associated with Comfort Discussing PrEP with Healthcare Providers among Black Cisgender Women
Authors: Irie Whitney C. , Mahone Anais , Nakka Raja , Ghebremichael Musie
Published: September 2023

Preexposure prophylaxis (PrEP) for HIV prevention uptake remains low among Black cisgender women in the United States, despite their disproportionate HIV burden. This study aimed to examine factors associated with Black women’s comfort discussing PrEP with healthcare providers and its link to their interest in PrEP use. A cross-sectional survey was conducted with a national sample of 315 Black cisgender women. Descriptive statistics and logistic regression models were utilized for data analysis. The results showed that 79% of Black women felt comfortable discussing PrEP with their healthcare provider. Age, recent healthcare provider visit, interest in PrEP, and positive social norms were associated with increased odds of comfort in discussing PrEP, while anticipated PrEP disapproval and stigma were associated with decreased odds. Older age was related to greater comfort, potentially due to increased familiarity and self-efficacy in discussing sexual health. Recent healthcare utilization indicated positive provider relationships, facilitating discussions about sexual health. Anticipating support from social networks positively influenced comfort levels. Conversely, PrEP-related stigma and anticipated disapproval were barriers to comfort. These findings highlight the importance of provider–patient communication and social support in facilitating PrEP engagement among Black cisgender women. Interventions should consider age-appropriate strategies and address structural and provider biases to improve PrEP discussions and promote HIV prevention.
A Critical Review of NIO’s Business Model
Authors: Pisano Alessandro , Saba Manuel , Baldovino Jair Arrieta
Published: September 2023

The present study reports a critical review of NIO′s business model considering the evolving landscape of the electric vehicle market and servicing. The objective of this study is to develop a comprehensive framework that facilitates the identification of key elements characterizing a company’s business model and highlights ongoing transformations crucial for adaptation and survival in a rapidly changing environmental context. Focusing on the case study of NIO, a relatively young Chinese original equipment manufacturer (OEM) specializing in high-tech electric cars, the research delves into the challenging scenario of the Chinese electric vehicle market, which recently faced a bubble in 2023. The market proliferation, supply chain disruptions, and price wars triggered by Tesla have resulted in a survival struggle for numerous automotive startups, leaving larger companies with increasing market shares. Despite facing adversities, NIO managed to secure a promising segment catering to premium-range battery electric vehicles (BEVs), establishing a competitive advantage through differentiation. By pursuing ambitious investments, the company aims to create economies of scope and achieve cost leadership, venturing into new market sectors and vertically integrating the production chain. Given NIO’s agility in adapting to market conditions, aggressive entry into new segments, and a strategic vision for the future, it serves as an excellent candidate for testing and validating the proposed framework. The research sheds light on NIO’s trajectory and offers insights into its potential for sustained growth in the dynamic electric vehicle market.
Reproductive Hormones and Female Mental Wellbeing
Authors: Wieczorek Karolina , Targonskaya Anna , Maslowski Katherine
Published: September 2023

Fluctuating hormone levels during the menstrual cycle and major reproductive cycle stages have been linked to mood changes, mental health conditions, and an increased likelihood of psychotic episodes. This knowledge could potentially be used for the predictive modeling of exacerbations and mood deterioration through the collection and analysis of data from wearables and apps. A literature search for a narrative review has been conducted using selected keywords in Pubmed, Embase and Google Scholar. Based on published data, it can be seen that hormonal changes affect the severity of symptoms in several mental health conditions, including depression, PMDD, PTSD, bipolar disorder and schizophrenia. The influence of FSH, LH, testosterone, and other hormone precursors has also been investigated, but there is less information available regarding their impact. E2 levels have been measured as a treatment–response biomarker and have demonstrated significant predictive ability for treatment responder groups. On the other hand, FSH has been demonstrated to be helpful in predicting treatment non-responder groups in schizophrenia. Monitoring reproductive hormones in combination with wearables or digital solutions has the potential to predict mood changes more effectively. Precise and frequent hormone measurements might prove to be more effective than relying on absolute threshold levels. Further research is needed to validate the utility and precision of hormone use in the field of mental health.
Redefining Dissociative Identity Disorder: An Exploration of Diagnostic Criteria
Authors: Altieri Sydney
Published: September 2023

This article is an investigation of the current diagnostic criteria set for dissociative identity disorder. Advancements in scholarly research have resulted in the current diagnostic criteria not reflecting new insights gathered since its most recent update. An examination of the progression of diagnostic criteria reveals the need for continual updates, including the proposed stipulation that while distinct, personalities seen in individuals diagnosed with dissociative identity disorder are fragmentations of a singular core, or host, personality. Recommendations for the application of the proposed amendments and its their strengths and limitations are discussed.
In Sickness and in Wealth: Mental Health, Income Levels, and COVID-19
Authors: Pawsey Hailey , Cramer Kenneth M.
Published: September 2023

Globally, COVID-19 has brought upon many challenges to mental health. Social distancing and isolation have led people to experience greater anxiety and negative affect, and financial distress has increased due to economic changes. Demographic features may differentiate the severity of distress individuals face. Using data from The Centre for Addiction and Mental Health (CAMH), the present study examined measures of psychological distress across a Canadian sample, identifying differences in age, sex, and income levels. Trends over time were observed. Lower-income Canadians reported higher distress. Women may be at greater risk than men, as well as younger compared to older Canadians. Psychological distress has remained relatively stable throughout the pandemic, although COVID-19 financial worry has lessened as people are not as worried about their finances. The findings of this study are informative of socioeconomic, sex, and age differences in mental health throughout the pandemic in a Canadian sample.
Feminism = Women’s Movement? The Effects of Terminology and Gender on Endorsement of Feminism
Authors: Wietholter Christyn , Hillard Amy
Published: September 2023

Building on past research, this study examined whether endorsement of feminism is still influenced by terminology used (i.e., feminism vs. women’s movement) and participant gender. One hundred undergraduates (36 men and 64 women) were randomly assigned to receive scale items that identified feminist values but used the terms feminism/feminist or women’s movement/women depending on the condition they were assigned. In addition, activism, acceptance of traditional gender roles, and feminist identification were measured. As expected, men endorsed feminism less than women overall, and participants in the women’s movement (vs. feminism) condition endorsed feminism more. When controlling for feminist identification, there was no gender difference in activism or acceptance of gender roles for participants in the feminism/feminist condition; however, women reported more activism and less acceptance of gender roles than men in the women’s movement/women condition. This study suggests that there is still a stigma surrounding feminism that influences its endorsement, especially among women.