bluuebunny/crossref_metadata_2025 huggingface dataset:
The role of Plaur-miR1-5p encoded within the urokinase receptor gene (Plaur) in angiogenesis
Authors: Klimovich P. S. , Reutov A. V. , Shchipova A. A. , Sysoeva V. Yu. , Arbatsky M. S. , Rubina K. A. , Semina E. V.
Published: July 2024

Angiogenesis plays a crucial role in tissue and organ regeneration by supplying essential nutrients and oxygen through the development of new blood vessels. Mesenchymal stem/stromal cells release extracellular vesicles that actively contribute to angiogenesis by carrying pro-angiogenic growth factors and microRNAs. MicroRNAs, small non-coding RNA molecules, are central players in angiogenesis, affecting endothelial cell proliferation, specialization, migration, apoptosis, and post-transcriptional gene expression.

In the present study, we investigated the impact of extracellular vesicles containing Plaur-miR1- 5p microRNAs on angiogenesis, specifically focusing on its initial stages: vascular cell migration and the formation of capillary-like structures. Recently we discovered Plaur-miR1-5p, which is encoded within the urokinase receptor gene (Plaur). However, the functions of this microRNA remain largely unexplored. Using a vascular ring model embedded in Matrigel, we demonstrate that Plaur-miR1-5p is encapsulated within extracellular vesicles and plays a regulatory role in capillary-like structure formation. Moreover, applying bioinformatic analysis, we have identified potential target genes of Plaur-miR1-5p that participate in the regulation of angiogenesis.

This study advances our comprehension of the fundamental processes governing angiogenesis, particularly the involvement of extracellular vesicles and microRNAs. Moreover, it sheds light on the functional aspects ofthe Plaur gene, contributing to a more profound understanding of its role in regulation of angiogenesis.
Post-stress changes in il-6 and bdnf mRNA levels in the hippocampus and blood of rats with a genetically determined contrast level of nervous system excitability
Authors: Mayanova E. Y. , Novozhilova S. A. , Shalaginova I. G. , Zachepilo T. G. , Dyuzhikova N. A.
Published: July 2024

Neuroinflammation is considered as one of the mechanisms by which stress can potentially lead to a disturbance of the functions of the central nervous system. The presence of neuroimmune dysfunction after stress, and what genetic factors increase the risk of post-stress neuroinflammation has not been sufficiently investigated. Genetically determined excitability of the nervous system is a promising marker of individual vulnerability to stress, manifested in post-stress disorders associated with the specifics of the formation of neuroinflammation.

The aim of this work was to study post-stress changes in the expression of pro-inflammatory il-6 genes in the blood and hippocampus and anti-inflammatory cytokine bdnf in the blood of rats with genetically determined high and low levels of excitability of the nervous system. Breeding animals were used, males of two strains of rats aged 5 months: with a high threshold (HT) of excitability of the nervous system (low excitable) and a low threshold (LT) of excitability of the nervous system (high excitable) from the biological collection of the Pavlov Institute of Physiology of the Russian Academy of Sciences. The stress model is a long-term emotional and painful stress according to the scheme of K. Hecht. Experimental and control animals were decapitated 24 hours, 7 days and 24 days after the end of stress exposure. Changes in the mRNA level of the il-6 and bdnf genes were evaluated using real-time PCR.

Chronic stress led to a significant increase in the level of il-6 mRNA in the hippocampus only in high excitable animals 24 days after the end of stress. In the blood, the mRNA level of this cytokine increased only in low-excitable rats. The expression of the bdnf gene in blood did not change in response to stress in any of the strains.
Implementasi Teknologi Informasi dan Komunikasi (TIK) Dalam Meningkatkan Daya Saing Umkm
Authors: Vera Maria  , Regi Regi  , Hayanti Hayanti
Published: July 2024

Information and Communication Technology (ICT) has emerged as a crucial determinant in business transformation, particularly for Micro, Small, and Medium Enterprises (MSMEs). This research aims to delve deeply into how the implementation of ICT in MSMEs contributes to enhancing their competitiveness. The research method employed is descriptive analysis with a qualitative approach, where data were collected through interviews with MSME owners who have implemented information technology in their operations.The results indicate that the integration of ICT has provided significant positive impacts on MSMEs. One of the key benefits is the enhancement of operational efficiency, where the use of information systems has expedited business processes and reduced operational costs. Additionally, MSMEs that adopt information technology also have broader market access through online platforms and social media, thereby enhancing sales potential and business growth. However, the implementation of ICT in MSMEs also faces several challenges, such as high implementation costs, limited access to infrastructure, and concerns about data security. Therefore, strong support from the government, non-governmental organizations, and the private sector is needed to provide training, technical assistance, and necessary infrastructure for MSMEs to harness the full potential of ICT.
Development Of Mobile-Based Learning Media Using The Construct 3 Application In Informatics Subjects
Authors: Angga Wicaksono  , Fahrur Rozi
Published: July 2024

The development of technology has affected the world of education in the content of the material and the learning process. At SMP Negeri 1 Besuki, it is known that technology-based learning media has never been developed during learning. The learning media that runs at SMP Negeri 1 Besuki is considered boring for students. This learning media is expected to help students to understand learning independently and improve the ability to understand informatics subjects.This research uses the ADDIE development model which consists of five stages, namely: analysis, design, development, implementation and evaluation. The ADDIE model provides an opportunity to evaluate development activities at each stage, this has a positive impact on the quality of development products. Based on the results of the feasibility test from the media expert of 83.63%, the results of the feasibility test on the material test amounted to 84.44% and student respondents amounted to 82%. If calculated the average is 83, 35%. Based on the criteria guidelines above this product is declared "Very Feasible". Mobile-based learning media using Construtc 3 in informatics subjects at SMP Negeri 1 Besuki can be utilized properly, introducing this learning media to teachers and other students. To Mr. / Mrs. Teacher in order to use and utilize mobile-based learning media using Construtc 3.
Strategi Penurunan Angka Stunting dan Analisis Hambatan Kebijakan
Authors: Wynne Frederica  , Al-Firdaus Laila Khalid , Fitriyah Fitriyah
Published: July 2024

Stunting has been proven to be a global issue that significantly impacts the growth of a country. In Indonesia, the problem of stunting has become one of the Strategic Priority Projects (Major Projects) in the National Medium-Term Development Plan 2022-2024. Based on this decision, each regents, including Kendal Regency, has also been promoting the acceleration of stunting reduction. Various medical studies have extensively discussed the dangers, factors, and the actions that can be undertaken to prevent stunting. However, they have yet to elaborate on the actual obstacles faced by local governments in their efforts to create stunting-free regions. The purpose of this study is to identify strategies for reducing stunting and the factors that may hinder the achievement of stunting reduction targets. In collecting research data, the author uses a qualitative descriptive method obtained from literature reviews, observations, and interviews involving relevant stakeholders.
Eksistensi Penyidik Pegawai Negeri Sipil pada Otoritas Jasa Keuangan dalam Sistem Hukum Acara Pidana Di Indonesia
Authors: Ramaputra Gede Angga Wirabhuwana
Published: July 2024

The absence of a form of unification in the regulatory product that regulates the concept and how the function of the investigation carried out by Civil Servant investigators (PPNS) at the Financial Services Authority (OJK) requires research that is an inventory of positive norms. This study aims to find out and understand the legal basis of PPNS at the OJK and its function in investigations in the financial services sector according to the Criminal Procedure Law System in Indonesia. This research is positioned at the intersection between the concept of 'Civil Servant Investigator' and 'Investigation'. This type of research is normative legal research as a positive legal inventory research through a statute approach. In relation to the object of research, the author analyzes legal materials through a Systematic Study and a Descriptive Study. Based on the research that has been done, it can be seen that PPNS investigators at OJK exist as one of the OJK investigators with Polri investigators who bear the burden of investigating criminal acts in the financial services sector. Formally, the investigations carried out are regulated in the same way as the investigations conducted by PPNS investigators at other institutions. PPNS investigators at OJK always coordinate with Polri investigators.
Abstrak
Ketiadaan bentuk unifikasi dalam produk peraturan yang mengatur mengenai konsep serta bagaimana fungsi penyidikan yang dilakukan oleh penyidik Pegawai Negeri Sipil (PPNS) pada Otoritas Jasa Keuangan (OJK) memerlukan adanya penelitian yang bersifat meng-inventarisasi norma positif. Penelitian bertujuan untuk mengetahui serta memahami dasar hukum PPNS pada OJK serta fungsinya dalam penyidikan pada sektor jasa keuangan menurut Sistem Hukum Acara Pidana di Indonesia. Penelitian ini diposisikan berada pada persinggungan diantara konsep ‘Penyidik Pegawai Negeri Sipil’ dengan ‘Penyidikan’. Penelitian berjenis penelitian hukum normative sebagai penelitian inventarisasi hukum positif melalui pendekatan undang-undang (statute approach). Berkaitan dengan obyek penelitian, penulis melakukan analisis bahan hukum melalui Systematical Study dan Descriptive Study. Berdasarkan penelitian yang telah dilakukan dapat diketahui bahwasannya penyidik PPNS pada OJK eksis sebagai salah satu dari bagian penyidik OJK bersama penyidik Polri yang menanggung beban penyidikan terhadap tindak pidana pada sector jasa keuangan. Secara formil, penyidikan yang dilakukan diatur sama dengan penyidikan yang dilakukan oleh penyidik PPNS pada lembaga lainnya. Penyidik PPNS pada OJK selalu melakukan koordinasi dengan penyidik Polri.
Kata Kunci : Penyidik PPNS, Otoritas Jasa Keuangan, Penyidikan
Pengaruh Perilaku Konsumtif Komunitas Penggemar NCT (NCTzen Bali) Terhadap Loyalitas Sebagai Penggemar
Authors: Maheswari Anak Agung Diah , Aditya I Gst. Ngr. A. Krisna , Pramestisari Nyoman Ayu Sukma
Published: July 2024

The K-Pop phenomenon makes it easy for fans to spend money to buy things related to their idols. K-pop fans easily spend money on their idols based on desire, pleasure, satisfaction, and to show their loyalty as fans. This behavior can be called consumptive behavior. This research aims to determine the influence of consumer behavior on loyalty among fans of the South Korean boygroup NCT. The sample in this research was 75 fans who were members of the NCTAZENBALI community. Data analysis techniques use Validity Test, Reliability Test, Classical Assumption Test, Simple Linear Regression Test, T Test, and Coefficient of Determination. The results of the tcount test at a margin of error of 5% show a consumptive behavior of 21,452. This means that there is a significant positive relationship between consumer behavior and someone's loyalty as an NCT fan in Bali. The strength of the relationship formed is at a very strong level with an R of 0.929. Meanwhile, the regression equation model obtained is Y = -6.709 + 0.364X. The resulting coefficient of determination is 86.3%, which is the percentage contribution of variable X to variable Y. Meanwhile the other 13.7% is explained by other factors.
 Abstrak
Fenomena K-Pop membuat penggemarnya mudah mengeluarkan uang untuk membeli sesuatu yang berkaitan dengan idolanya. Penggemar K-pop dengan mudah mengeluarkan uang untuk idolanya didasari oleh keingan berlebih, kesenangan, memberikan kepuasan, dan demi menunjukkan loyalitas mereka sebagai penggemar. Perilaku inilah yang dapat disebut sebagai perilaku konsumtif. Penelitian ini bertujuan untuk mengetahui pengaruh perilaku konsumtif terhadap loyalitas pada penggemar boygroup asal Korea Selatan NCT. Sampel pada penlitian ini adalah penggemar yang tergabung dalam komunitas NCTAZENBALI sebanyak 75 orang. Teknik analisis data menggunakan Uji Validitas, Uji Reliabilitas, Uji Asumsi Klasik, Uji Regresi Linier Sederhana, Uji T, dan Koefisien Determinasi. Hasil pengujian thitung pada margin error 5% menunjukkan perilaku konsumtif sebesar 21,452. Hal ini memiliki arti bahwa terdapat hubungan yang signifikan positif antara perilaku konsumtif dan loyalitas seseorang sebagai penggemar NCT di Bali. Adapun kekuatan hubungan yang terbentuk adalah berada pada tingkatan yang sangat kuat dengan R sebesar 0,929. Sedangkan model persamaan regresi yang diperoleh adalah Y = -6,709 + 0,364X. Koefisien determinasi yang dihasilkan adalah sebesar 86,3% yang merupakan persentasi kontribusi variabel X terhadap variabel Y. Sementara itu 13,7% lainnya dijelaskan oleh faktor lain.
Kata Kunci: Penggemar K-pop, NCT, Loyalitas, Perilaku Konsumtif
Evaluation of the effectiveness of adaptive technologies to improve the education of students with visual impairments
Authors: Miranda Arbelaiz Mónica Elizabeth , Rivera Rojas Jorge Andrés , Rumbaut Rangel Dayron , Yánez Cando Xavier Oswaldo
Published: July 2024

The condition of disability can be an indication of inequality, limitation, lack of opportunities and discrimination in all aspects of life and education is no exception. The research is aimed at analyzing how the use of tools based on typhotechnology such as the braille system, screen readers and audiobooks and the closed abacus contributes to increasing the accessibility, participation and performance of students with 80% of visual disabilities. . It was necessary to apply a methodology framed in the socio-critical, field and experimental paradigm, with a mixed quali-quantitative nature and a descriptive-explanatory approach, exploratory factor analysis was used. The results suggest a significant impact on the academic progress of the experiment group related to the use of the tools, the factor analysis highlights the existence of a common underlying factor that influences performance and their ability to learn compared to the use of the tools, identifying a variation in performance according to the specific needs and abilities of each student, which highlights the importance of inclusive education with adaptive tools that respond to the needs and abilities to increase educational quality.
La gestión de residuos en el marco de las competencias de las entidades locales
Authors: Ruiz de Apodaca Espinosa Ángel
Published: July 2024

El presente trabajo aborda la tarea de las entidades locales en relación con su competencia de gestión de los residuos municipales, esto es, su recogida, transporte y tratamiento. Igualmente, analiza los objetivos y los instrumentos técnicos, jurídicos y económicos para su consecución.
El nuevo régimen jurídico de las tasas en materia de residuos
Authors: Álvarez Menéndez Estefanía
Published: July 2024

El artículo 11 de la Ley 7/2022, de 8 de abril, de residuos y suelos contaminados para una economía circular, trae consigo novedades importantes en la configuración de las tasas y prestaciones patrimoniales públicas no tributarias por recogida, transporte y tratamiento de residuos para favorecer su reducción y recogida selectiva. Se impone su establecimiento, así como su carácter específico, diferenciado y no deficitario. Asimismo, se requiere que estas implanten sistemas de pago por generación, en consonancia con el principio de “quien contamina paga”. La medición individualizada de los residuos generados supondrá todo un reto para los municipios y una revolución en la cuantificación de estos instrumentos de financiación, que afectará también a otros elementos esenciales, como el hecho imponible o los sujetos pasivos.
L’importance des offrandes et sacrifices en période d’épidémies dans les cultes de guérison en l’honneur d’Asclépios en Grèce ancienne
Authors: DIOUF Pierre Mbid Hamoudi
Published: July 2024

This paper deals in part with the origin of medical cults in ancient Greece. The current tendency is to recall that the Greeks generally link the introduction of new cults with the advent of happy or unfortunate events: hence the installation of healing cults, especially in Asclepius the god par excellence of medicine, in times of epidemic. The consecrations of a whole city plagued by the plague, the testimonies of godliness and hope, the necessity of collective and individual sacrifices and prayers, to guarantee the covenant between the suppliant and his god and to guarantee the protection of the gods in all circumstances. Thus in this article we have taken an interest in worship at Asclepius, especially concerning its genesis and hegemony in certain localities, but also the importance given to ritual sacrifices in times of crisis, especially in the Greek world
ENCOURAGE STUDENTS TO THINK CRITICAL AND INNOVATIVE WITH THE PROBLEM BASED LEARNING MODEL
Authors: Nasya Putri Nabila  , Fandra Apriyandi Rahayu  , Elfina Elfina Mei Rahmawati
Published: July 2024

Critical and innovative thinking are essential skills for students to develop in order to make appropriate decisions and solve problems with creative and effective solutions. This study aims to explore how the Problem Based Learning (PBL) model can encourage students to think critically and innovatively. The research method used is qualitative with a case study design applied within the PBL framework. The results show that the teacher's role is highly significant in shaping students' critical and innovative thinking skills through this learning model. Some strategies that teachers can use to encourage critical and innovative thinking include creating and facilitating interactions among students during the learning process, training students to produce work, and developing their thinking processes
ENHANCING CRITICAL THINKING SKILLS THROUGH HISTORY EDUCATION AND DIGITAL LITERACY IN THE TECHNOLOGICAL ERA 4.0
Authors: Rahayu Alfian Dimassaujana , Soviano Dwi Edwinson
Published: July 2024

The development of Information and Communication Technology (ICT) is currently developing rapidly and rapidly. With the existence of Information and Communication Technology, to get any information you want to search for, you can access it via laptops, cellphones and so on that are connected to the internet network. Use a mixed approach (mixed methods) which combines quantitative and qualitative methods to get comprehensive data. Activities in learning at school effectively by an educator can create a pleasant learning process. The effectiveness of learning is a measure of the success of a school in providing education, so it is very necessary to have learning efforts that are able to arouse children's interest and willingness in learning activities to develop all the potential in children. which is combined with the five aspects of development and instilling strong religious values ​​in the child (Rohmawati, 2015). From the results of this research it can be concluded that the existence of Information and Communication Technology is very beneficial for the world of education. And based on the results of distributing questionnaires to respondents in the history education study program.
Organizational Resilience and Construction Materials: Technological Strategies to Enhance Sustainability in Construction Companies
Authors: Torres Arnaldo Yana , Gurumendi Johanna Maricela Bósquez , Haro Marco Mauricio Chávez , Yañez Edward Jimmy Pandia
Published: July 2024

A documentary review was carried out on the production and publication of research works related to the study of the variables Construction Companies, Innovation and Business Sustainability. The purpose of the bibliometric analysis proposed in this document was to know the main characteristics of the volume of publications registered in the Scopus database during the period 2018-2023, achieving the identification of 53 publications. The information provided by this platform was organized through graphs and figures categorizing the information by Year of Publication, Country of Origin, Area of Knowledge and Type of Publication. Once these characteristics have been described, the position of different authors regarding the proposed theme is referenced through a qualitative analysis. Among the main findings made through this research, it is found that the United States with 8 publications was the country with the highest scientific production registered in the name of authors affiliated with institutions in that nation. The Area of Knowledge that made the greatest contribution to the construction of bibliographic material related to the study of the variables Marketing, Organizational Development and Times of Change was Administration, Business and Accounting with 18 published documents, and the most used Type of Publication during the period indicated above were Journal Articles with 50% of the total scientific production.
Legal Protection of Personal Images in the Era of Modern Technology 'Comparative Study'
Authors: Sayed Abdelrazek Wahba
Published: July 2024

Technology creates serious problems as it facilitates obtaining a person's image without their knowledge, constituting a violation of their right to privacy. Hence, our research titled 'Legal Protection of Personal Images in the Era of Modern Technology' aims to demonstrate how the personal image is protected through the rules of Egyptian and Algerian civil law, assessing their sufficiency and effectiveness in addressing the damages resulting from infringements upon it. Our findings lead to several conclusions and recommendations, emphasizing that the right to one's image is inherent to human personality, necessitating effective protection by developing civil law rules to confront digital technologies, especially when using facial recognition technology through the use of electronic profiles without the knowledge of their owners.
Understanding Employee Wellness for Improved Performance and Achieving Sustainable Development Goal 3
Authors: Vyas-Doorgapersad Shikha
Published: July 2024

The study examines the need, importance, and advantages of wellness that organisations should consider for their employees' general well-being. It is imperative to note that employee wellness is also linked to sustainable development goal 3 that deals with healthy living and wellness and expects organisations to abide to the goals and targets within their organisational context. The study is grounded in qualitative desktop research. The data is gathered through iterature and document reviews. The data was analysed through document and conceptual analysis. The findings explore the implementation gaps in employee wellness programmes, that also affect the effective realisation of SDG 3. In South Africa, societal issues such as health care, health sector financing, disease control and prevention pose a significant challenge to organisations and their ability to operate at peak performance. This is due to the main contributing factor, which is employee performance. The study suggests that this is imperative in every sector to sustain the physical, emotional, psychological, and health wellness of individual professionals, at every level, that has a positive impact on sustaining performance of the organisations. Effective wellness programmes may decrease stress levels and assist professionals to perform better.
Identification of Bacterial Endophytes Isolated from Different Medicinal Plants
Authors: Muhtari Kasim , Sailaja Inampudi , Shekhawat Beena Kanwar , Kaura Sonia , Mehta Saurabhkumar
Published: July 2024

Plants have very potential compounds to live on earth as they supply 90% of human calorie intake, 80% of protein intake directly, and perhaps the most vital sources of medicine with a vast diversity of microorganisms. As such it’s important to know those microorganisms, their kinds, the features they possess, and the significant compounds/metabolites they can produce. So, this study is based on identifying such microorganisms. To achieve this aim, isolation of endophytes has been done to know their biochemical activities and properties. Various identification procedures have been followed to get pure endophytic strains without any contamination. Surface sterilization of the plant tissue is a must in this progress, various surface sterilization techniques have been tried and finally, for 4/5 plant tissues, sodium hypochlorite and ethanol were given the best result and for 1/5 with the addition of mercuric chloride were the standardized method for surface sterilization. About 30 different bacterial endophytes have been isolated from five kinds of medicinal plants. 4% sodium hypochlorite and 75% ethanol were found effective in sterilizing the surface of Psidium guajava, Cassia occidentalis, Calotropis procera, and Hibiscus rosa-sinensa. While Mangifera indica required an addition of 0.1% mercuric chloride. 19 strains isolated were Gram-positive, 11 Gram-negative (5 were Lactose fermenters and 6 were not), and most of which were bacilli. All isolates have shown different biochemical results, 25 showed a positive result for oxidase, and 28 gave a positive result for catalase. Most of the endophytes identified in this work are Bacillus spp. However, this study highlighted the significance of surface sterilisation and most importantly the presence of potential endophytes capable of producing novel bioactive compounds usable in pharmaceutical/medicinal application.
Cadaveric Study: Sign of Leser-Trélat Associated with Breast Cancer
Authors: Cochran Brigitte , Arya Savita , Dhiman Shiv
Published: July 2024

INTRODUCTION: Seborrheic keratoses (SK) is considered the most common benign skin lesions found in individuals that are middle aged and older. In dermatology practice, these lesions pose no threat to the individual but can be concerning for cosmetic and underlying malignancy reasons when they cover most of the skin surface. Of specific concern is the sign of Leser-Trélat, which has been documented as a cutaneous harbinger of underlying malignancy associated with proliferation of the size and/or number seborrheic keratoses. The rare sign is usually caused by malignancies such as gastrointestinal adenocarcinoma, but also lung, kidney, liver, or pancreatic cancer. This case report will describe the histology of the skin lesions in Lesar Trélat and analyze the current literature regarding its association with breast cancer, which is quite rare. RESOURCES: For this case study, a cadaver from the body donor program in Philadelphia College of Osteopathic Medicine (PCOM), South Georgia was used. Skin samples were sent to Colquitt Regional Center for processing, where sections were embedded in paraffin and were stained with H&E stain. A pathologist reported histopathological findings of the skin lesions and the breast tissue samples. DESCRIPTION: Multiple SK lesions covering the face, abdomen, back, as well as both upper and lower extremities were observed in one of the cadavers in the gross anatomy laboratory. Due to the significant number of pigmented, verrucous lesions, the sign of Leser-Trélat was clinically postulated, later confirmed during routine laboratory dissection of the breast tissue. Histology sections confirmed not only multiple SK lesions in the skin, but also revealed an associated breast cancer in the form of an infiltrative ductal carcinoma. SIGNIFICANCE: The sign of Leser-Trélat is rare by itself and its association with breast cancer is even more uncommon. Once a clinician recognizes the multiple SK eruptions, the patient should be meticulously investigated for not only for an underlying GI malignancy, but also for other cancers like breast cancer. Additionally, a case report confirmed malignant melanoma that mimicked sign of Leser-Trélat, warranting the importance of further analyzing the pathology diagnosis when there is a proliferation of multiple seborrheic keratoses.Therefore, biopsy and histology diagnosis is crucial for ruling out both cutaneous as well as underlying malignancies and should be encouraged when patients present in clinic rather than assuming the typical benign characteristics of seborrheic keratosis.
Analysis of the Profile of Primary Diagnosis Codes for Diabetes Mellitus Inpatients at Dr. Soekardjo Regional General Hospital Tasikmalaya Based on ICD-10, ICD-11, and SNOMED CT
Authors: Wahyu Putri Shafa Salsabila , Suryani Kurniasih Dewi Lena , Sukawan Ari , Barsasella Diana
Published: July 2024

Background: the accuracy of a diagnosis code is essential in financing health services and diseases and procedure indexing and hospital management information. Based on the results of the preliminary study, diabetes mellitus is among the top 10 diseases. While coding 10 medical record documents, three consisted of 30% which were accurate, and the seven recorded 70% were found to be accurate. The four-character of the code was predominantly the character with many inaccuracies. Therefore, the researchers conducted a study on the accuracy of a diagnosis code at Dr. Soekardjo Regional General Hospital specifically on inpatient cases of diabetes mellitus in 2022. Methods: A quantitative type of study with a descriptive research design was implied in the study. The study object is data coding of diabetes mellitus cases. Data are collected by observation and interviews Results: According to the research results, diabetes mellitus is one of the top 10 diseases, while 40 medical record documents were coded, 20 (50%) were inaccurate and 20 (50%) were accurate, while the highest percentage of unaccuracy occurs in the fourth character of the code. The alignment of codes based on ICD-11 revealed that 10 documents (25%) were not aligned due to lack of specificity regarding ulcer complications and gastropathy.The alignment of codes based on SNOMED CT showed that 40 documents were aligned with the SNOMED CT clinical phrase standards. Conclusion: The inaccuracies in diabetes mellitus diagnosis coding at Dr. Soekardjo Regional General Hospital are attributed to less specific diagnoses, unclear handwriting by doctors in patient medical records, and coding personnel still facing difficulties in determining complication coding. The researchers suggest solutions such as involving coders and medical personnel in training and socialization activities related to diagnosis codes, particularly for Diabetes Mellitus.
Babesia: una revisión bibliográfica de su etiología, síntomas, hábitat, transmisión, epidemiología y ciclo evolutivo en Ecuador.
Authors: Santamaria Allyson , Duarte Jonathan , Lema Erika , Sigcha Valerie
Published: July 2024

This scientific article addresses babesiosis, a parasitic disease transmitted by ticks that primarily affects cattle in Ecuador. The authors conducted a comprehensive literature review, utilizing specialized databases such as PubMed, Scopus, and Web of Science, to gather information on the etiology, epidemiology, and life cycle of Babesia in the Ecuadorian context. The results indicate that babesiosis is endemic in Ecuador, with a prevalence ranging from 15% to 23% in different provinces. The most relevant species are B. bovis and B. bigemina, transmitted by ticks of the genera Ixodes and Rhipicephalus. The disease has a significant economic impact on the livestock industry, causing losses in meat and milk production, as well as costs associated with treatment and control. The authors conclude that it is necessary to implement comprehensive control and prevention strategies, including effective tick control programs and farmer training. They recommend developing health policies that promote collaboration among research institutions, veterinary services, and producers. Additionally, they suggest continuing research on the epidemiology and pathogenesis of Babesia to develop more effective strategies. Finally, they emphasize the importance of a holistic approach that considers veterinary, economic, and public health aspects to effectively address babesiosis in Ecuador.
The Imposition By Member States Of Additional Requirements Not Provided For In Directive 2009/133/Ce For The Application Of The Tax Neutrality Regime: An Analysis In Light Of The Judgment Of The Ecj Of 16 November 2023, Case C-318/22 (Ge Infrastructure Hungary Holding Kft.)
Authors: Quintas Seara Alberto
Published: July 2024

Abstract: This paper aims to analyse the doctrine established by the European Court of Justice (ECJ) in its judgment of 16 November 2023 (case C-318/22, GE Infrastructure Hungary Holding Kft.). In that judgment, the Court examined the compatibility with Directive 2009/133/EC of Hungarian legislation which made the application of the tax neutrality regime in the case of a partial division subject to requirements relating to a reduction in the share capital of the transferring company or to a reduction in the shareholding of the shareholder of the transferring company. In essence, the ECJ concluded that Member States may not make the application of the tax neutrality regime laid down in Directive 2009/133/EC subject to additional requirements nor provided for by that Directive. Therefore, the ECJ judgment is relevant in relation to those Member States whose domestic tax laws make the application of the tax neutrality regime set out in Directive 2009/133/EC subject to requirements not provided for by the Directive itself. Keywords: Directive 2009/133/EC; Business reorganisations; EU Law.
O BLOCKCHAIN E A INTELIGÊNCIA ARTIFICIAL NA AJUDA HUMANITÁRIA
Authors: de Morais Figueiredo Cruz Giovana
Published: July 2024

Resumo: Estamos atualmente imersos em uma era de inovações tecnológicas, notadamente no contexto do avanço contínuo da inteligência artificial. Este fenômeno tem se manifestado de maneira significativa na integração da biometria em nossas atividades cotidianas, exemplificada pelo seu emprego em dispositivos como computadores pessoais e celulares. Contudo, é digno de nota que a aplicação da biometria em iniciativas humanitárias tem emergido de maneira revolucionária, visando contribuir positivamente para o acesso aos direitos humanos. A biometria, que transcende a mera observação superficial, aliada ao blockchain, revela-se capaz de armazenar extensos conjuntos de informações, estabelecendo um histórico valioso para operações humanitárias. Essa integração possibilita doações de forma anônima, ágil e eficiente, além de preservar registros documentais abrangentes sobre cada indivíduo refugiado. Notavelmente, o atual debate na União Europeia sobre o projeto de regulamentação da inteligência artificial classifica a biometria como uma tecnologia de alto risco para os usuários, em grande parte dos casos. No entanto, esta análise buscará demonstrar, por meio de uma revisão bibliográfica e análise documental, que a inteligência artificial pode ser uma aliada essencial na formulação e gestão abrangente de políticas públicas migratórias. Além de sua aplicação pontual na ajuda humanitária, propõe-se que a inteligência artificial contribua para a inclusão social de refugiados e migrantes. Por último, argumenta-se que, para que a utilização dessas ferramentas – biometria em conjunto com sistemas de inteligência artificial e tecnologia blockchain – beneficie a sociedade, é imperativo que o texto do Regulamento Europeu de Inteligência Artificial dedique atenção especial a esses aspectos. Essa atenção deve ser direcionada não apenas para evitar a inviabilização do uso dessas tecnologias, mas, acima de tudo, para garantir transparência, segurança, rastreabilidade e não discriminação em sua aplicação. Palavras-chave: Blockchain; Inteligência Artificial; Biometria; Refugiados.
WATCHING “YOU”: O CRIME DE STALKING PARA ALÉM DA FICÇÃO
Authors: dos Santos Bomfim João Victor
Published: July 2024

Resumo: Este trabalho aborda o fenômeno de stalking a partir da sua apresentação na série televisiva “You” de Greg Berlanti e Sera Gamble. Foram analisadas as principais características do fenômeno e as controvérsias conceituais que envolvem o tema. Aborda-se também a recente criminalização da conduta no Brasil pela Lei 14.132/21 e os impactos na sanção da norma. Por fim, o texto busca perspectivas internacionais quanto à criminalização do stalking. Para a elaboração do artigo, realizou-se revisão de literatura em base de dados acerca do tema, contemplando estudos nas áreas da Sociologia, do Direito e da Psicologia; além dos dispositivos normativos que tratam do assunto. Nota-se, que o Direito Penal, ramo autônomo do direito, possui finalidades específicas que o conecta com a criminologia, possuindo autonomia para funcionar como instrumento de controle das classes privilegiadas sobre as menos favorecidas socialmente. Dessa forma, a história retratada pela série “You”, desenvolvida neste artigo, qualificam de certa forma características de controle praticadas pelo sujeito, que corroboram com a necessidade de se consolidar, de maneira concreta, a criminalização desse tipo de ato. Como conclusão, percebe-se que apesar dos avanços nos debates sobre o stalking nos últimos anos, pesquisadores, legisladores e juristas ainda precisam enfrentar as controvérsias conceituais sobre o tema e reunir esforços a fim de proteger as vítimas desta conduta com respostas legais efetivas. Palavras-chave: stalking; perseguição; assédio; ficção; You; Lei de Stalking; impactos da criminalização.
O ADVENTO DOS DIREITOS DIGITAIS EM PORTUGAL E NA UNIÃO EUROPEIA
Authors: Simões Barata Mário , Resende Alves Dora
Published: July 2024

Resumo: O artigo retrata a evolução das novas tecnologias e os desafios jurídicos que as utilizações das mesmas suscitam nos nossos dias, bem como as respostas de diversos Estados e a posição da União Europeia nesta matéria. Para tanto, explica o contexto do surgimento das declarações digitais, com especial destaque para a evolução das plataformas digitais e expõe as diversas fases de desenvolvimento destas de acordo com o trabalho de Simão Mendes de Sousa. De seguida, alude à resposta portuguesa que passou pela adoção da Carta Portuguesa de Direitos Humanos na Era Digital aprovada pela Lei nº 27/2021, de 17 de maio, e o conteúdo da mesma (i.e., os vários direitos consagrados). Apresenta ainda as críticas da doutrina que foram dirigidas às opções do legislador que conduziram à revogação de uma norma atinente ao direito à proteção contra a desinformação, na medida em que configurava uma forma de censura proibida pelo artigo 37º da Constituição da República Portuguesa. Por fim, constata que as respostas unilaterais são insuficientes e que a resolução jurídica dos problemas suscitadas pela utilização das novas tecnologias na era digital passa pela resposta da União Europeia e a um Direito Constitucional multinível assim como às ideias fundamentais da limitação do poder e a garantia de direitos. Palavras-chave: plataformas digitais; direitos digitais; União Europeia; Portugal; Carta Portuguesa de Direitos Humanos na Era Digital.
NORMA E UTOPIA
Authors: Gonçalves Braga Maria de Fátima
Published: July 2024

Resumo: Visamos refletir sobre a natureza utópica de uma norma do ordenamento jurídico-tributário, o art. 38º, n.º2 da LGT que consagra a Cláusula Geral Antiabuso, a partir da análise e compreensão da Utopia de Tomas Morus. Observada a organização da comunidade da Utopia, onde o indivíduo se rege pela prossecução do bem comum, onde cada indivíduo procura viver com respeito pela felicidade alheia, partiremos para a comunidade atual, onde o individualismo prevalece sobre a ideia de comunidade, o bem-estar do outro não se inscreve nas preocupações do indivíduo que se orienta numa perspetiva de ter mais do que de ser, importa perceber como é concebido o bem individual e que lugar tem o todo. Refletindo sobre a natureza utópica da norma tributária (CGAA), o horizonte do pagamento de imposto, por cada sujeito, de acordo com a sua capacidade contributiva, será o objetivo a atingir. O nosso objetivo é perceber se esta norma, caraterizada pela abertura e dinamismo, é uma norma utópica, quais os seus objetivos, visando que horizonte, em que medida ruma à perfetibilidade, à realidade imaginada, assumindo a responsabilidade de concretizar o imaginado, a utopia contida na norma, sem esquecer que, na utopia legislativa, a evolução dos valores da sociedade assume-se como o horizonte a atingir. Palavras chave: utopia, norma, CGAA, perfectibilidade.
AS DEFICIÊNCIAS NA APLICAÇÃO DA INTEGRALIDADE À SAÚDE AO CIDADÃO BRASILEIRO
Authors: Basso Rialto Paula , Pinha Alonso Ricardo , Martines Heinrich Ferrer Walkiria
Published: July 2024

Resumo: O presente artigo visa problematizar o campo da promoção da saúde, que é um direito social, demonstrando de que forma evoluímos até atingir um importante instrumento de poder que é a biopolítica, a qual gerou o Sistema Único de Saúde do Brasil para atendimento universal e integral a todos os cidadãos brasileiros. No cenário pós-revolução industrial, o Estado passou a se utilizar da biopolítica para controlar a vida no corpo da população por meio da tecnologia do poder, que seriam as políticas públicas. Para o fornecimento e garantia deste direito social, previsto constitucionalmente no artigo 196, criou-se o SUS, o qual é guiado pelas diretrizes de descentralização, atendimento integral e participação popular, com base nos princípios da universalidade, integralidade e igualdade firmados pela Constituição Federal. Outro ponto fundamental é sobre a organização administrativa para a concessão da saúde pública que determina que as ações e serviços façam parte de uma rede regionalizada e hierarquizada, o qual se sustenta com recursos do orçamento dos entes federados. Apesar disso, esse sistema enfrenta alguns gargalos como a deficiência na prestação do direito a saúde em razão da lentidão na atualização dos medicamentos e tratamentos oferecidos, o que se objetiva demonstrar por meio do método dedutivo que pode ser enfrentado por meio de uma otimização e limites no uso dos recursos públicos. Palavras-chave: Biopoder; Saúde Pública; Deficiência.
A theoretical study on the electronic and optical properties of M-TiO2/ZnO (M=Li, Na, K, Fe) toward application in photocatalysis
Authors: Nguyen Thi Kim Giang  , Nguyen Thu Hien  , Duong Quoc Hoan  , Thi Thu Ha Nguyen
Published: July 2024

This study employs the tight-binding density functional method GFN1-xTB to investigate the structural and electronic properties of TiO2-ZnO and TiO2-ZnO composite materials modified by Li, Na, K, and Fe metals. Computational analyses reveal the formation of weak covalent bonds between the TiO2 and ZnO components within the composite system. Doping TiO2-ZnO with metals induces significant alterations in the electronic structure, particularly in terms of ionization energy and global electrophilic index. The UV-VIS spectra are calculated using real-time time-dependent density functional theory with xTB Hamiltonians. The obtained results demonstrate minimal impact of metal presence on the absorption spectrum of TiO2-ZnO, but significant influence on the recombination potential of photogenerated charge carriers. It is suggested that Fe/TiO2-ZnO and Li/TiO2-ZnO will demonstrate higher photocatalytic activity than the pristine TiO2-ZnO material.
Nghiên cứu tổng hợp vật liệu composite SiO2/g-C3N4 cho quá trình quang xúc tác phân hủy rhodamine B
Authors: Nguyễn Thị Lan , Phan Thị Thùy Trang , Nguyễn Hồng Liên
Published: July 2024

In this study, a visible-light-driven SiO2/g–C3N4 composite was prepared by heating a mixture of SiO2 and urea. The products were characterized by X-ray diffraction (XRD), infrared spectra (IR), scanning electron microscopy (SEM), and ultraviolet–visible diffuse reflectance spectroscopy (UV-Vis DRS). Results indicate that the composite only contained SiO2 and g-C3N4, and the SiO2/g–C3N4 composite had higher photocatalytic activities in the degradation of rhodamine B (82.2%) compared to the pristine g-C3N4 (43.9%) under visible light. The SiO2/g–C3N4 composite is a promising new material for the photodegradation of organic pollutants in wastewater due to its high photocatalytic performance, low cost, and convenient collection for reuse.
ASPEK NEUROSAINS DALAM PATOFISIOLOGI PRURITUS NOKTURNAL
Authors: Trasia Reqgi First , Mustofa Samsul , Purwaningsih Endang , Herlinawati Sri Wahyu
Published: July 2024

Itching at night in scabies patients is considered a very disturbing symptom. It is known that the main role of the itch sensation and subsequent motor response is to remove environmental influences from the skin, especially arthropods. The purpose of this article is to provide an understanding of the overall physiology and associated pathophysiology of itch. This article focuses on the neuronal aspect, as the nervous system is necessary to perceive the sensation of itch, as well as the multidirectional connections between the nervous and immune systems that influence the transmission of itch from the skin to the spinal cord. Itching is felt by skin nerve fibers called pruriceptors. These primary afferent fibers function as antennae and continuously sense the skin environment to detect and respond to cues. All major afferents project to the dorsal part of the spinal cord. Peptidergic and nonpeptidergic neurons target different areas of the dorsal superficial lamina. Based on this review, it can be concluded that noxious and pruritic stimuli are mostly processed in the superficial dorsal horn, whereas deeper dorsal horn neurons receive nociceptive and pruritic input via polysynaptic innervation.
FORMULASI DAN UJI AKTIVITAS SEDIAAN PAPER SOAP SABUN CUCI TANGAN EKSTRAK ETANOL DAUN JAMBU BIJI (Psidium guajava L.) TERHADAP Staphylococcus aureus
Authors: Wahid Hilmiati , Sulaiman Abdul Wahid , Najamuddin Mirfaidah , Pratiwi Elzha Meilya
Published: July 2024

Jambu biji (Psidium guajava L.) memiliki kandungan alkaloid, flavonoid, minyak atsiri, saponin, dan tanin yang memiliki kemampuan sebagai bahan antibakteri seperti bakteri Staphylococcus aureus. Penelitian ini bertujuan untuk mengetahui apakah ekstrak etanol daun Jambu biji (Psidium guajava L.) dapat dibuat menjadi sediaan Paper soap sabun cuci tangan yang memenuhi persyaratan stabil secara fisik dan untuk mengetahui pada konsentrasi berapa Paper soap sabun cuci tangan ekstrak etanol daun Jambu biji (Psidium guajava L.) efektif menghambat Staphylococcus aureus. Metode penelitian dilakukan dengan cara metode disk diffusion (Kirby-Bauer test) dengan menggunakan tiga variasi konsentrasi 15%, 20%, 25% dan dua kontrol pendukung yaitu kontrol (-) merupakan sediaan Paper soap tanpa ekstrak juga kontrol (+) yaitu Paper soap. Dari hasil penelitian disimpulkan bahwa ekstrak daun Jambu biji (Psidium guajava L.) dapat dikembangkan menjadi sediaan Paper soap sabun cuci tangan yang stabil secara fisik. Serta sediaan memiliki aktivitas sebagai antibakteri terhadap Staphylococcus aureus dengan konsentrasi yang paling efektif yaitu pada konsentrasi 25% sebesar 20,5 mm ± 0,63 termasuk kategori sangat kuat.