bluuebunny/crossref_metadata_2025 huggingface dataset:
Fixation of olecranon osteotomy only with 6′5 mm partially trheaded cancellous screw is a safe an effective method used in surgical management of distal humerus fractures
Authors: Cañete San Pastor Pablo , Lopez Valenciano Javier , Copete Ivan , Prosper Ramos Inma
Published: January 2021

Purpose

The objective of this study is to demonstrate the safety and efficacy of the osteosynthesis with a 6.5 mm screw and washer of a Chevron shape olecranon osteotomy performed for the surgical approach of supraintercondylar fractures of the distal humerus, achieving union and complication rates better or similar to other published case series.

Methods

From 2009 to 2019, 26 patients underwent fixation of an olecranon osteotomy for the treatment of a supraintercondylar fracture of the distal humerus with partially threaded cancellous cannulated screws of 6.5 mm diameter with a washer. The patients were followed for at least 1 year, taking radiographs the day after the surgery, at 3, 6 and 12 months. Complications have been collected: infection, loss of reduction, non-union, delay of union, discomfort of the osteosynthesis hardware.

The diameter of the ulna medullary canal diaphysis was also measured in all patients.

Results

Consolidation of the osteotomy was 100% at 12 months. The average time of radiological consolidation was 112 ± 12 days. The average size of the ulna medullary canal diaphysis was 6′06 ± 0′16 mm on anteroposterior radiographs and 5′65 ± 0′14 mm on lateral radiographs. The mean screw length was 102′31 mm ± 3′89. We found 1 acute infection, 2 osteotomies delays of union (one of these cases was the acute infection case), one early osteosynthesis failure and 1 wound dehiscence.

Conclusions

Olecranon ostetomy fixation with a 6′5 mm cancelous partial threaded screw and washer is safe and effective with a high consolidation rate and excellent results and with complication rates similar to or lower than other fixation methods published. Long enough screws must be used to get a good cortical grip with enough stability.

Level of evidence

Level IV, Case series, retrospective review.
Capacitance measurements on integrated conductors for detection of matrix cracks in GFRP
Authors: Buggisch Christina , Gagani Abedin , Fiedler Bodo
Published: January 2021

For the reliable and cost-efficient application of glass fibre polymer composites in structural applications, knowledge of the damage state of the material during operation is necessary. Within this work, a structural health monitoring method based on in-situ electrical capacitance measurements is presented, which enables damage monitoring in glass fibre reinforced polymers. For this purpose, individual glass fibre rovings in a non-crimp fabric were replaced by carbon fibre rovings at regular intervals. Additionally, specimens with solid or stranded copper conductors were manufactured to gain insights into the influences of conductor material and composition. The modified fabrics were implemented as 90 ∘ layers of [0/904]s glass fibre polymer cross-ply laminates. To monitor the progressive damage, conductive rovings were contacted, forming the capacitor walls of interleaved capacitors. Carbon fibre conductors show higher sensitivity of the capacitance to crack formation than solid or stranded copper conductors. Capacitance decrease measured in-situ during tensile tests on specimens with carbon fibre conductors shows a high correlation with crack initiation, further crack formation and speed of crack evolution. An analytical model can describe the correlation based on the assumptions of an ideal plate capacitor. Thus, the structural health monitoring method developed in this work can reveal in-situ knowledge of the material damage state.
Correction to: Extended blood group profiles for Malays, Chinese, and Indians in Peninsular Malaysia
Authors: Hajar Che Ghazali Norul , Zefarina Zulkafli , Riffin Nor Suhaila Md. , Mohammad Tuan Hulwani Tuan , Hassan Mohd Nazri , Poonachi Prathapan , Safuan Sabreena , ElGhazali Gehad , Chambers Geoffrey Keith , Edinur Hisham Atan
Published: January 2021

An amendment to this paper has been published and can be accessed via the original article.
Cervical vestibular evoked myogenic potential and high-frequency audiometry results in Behçet’s disease
Authors: Abdel Baki Noha M. , Zahran Abeer Mohamed Ahmed , Dabbous Abeir Osman , Koura Rabab Ahmed , Hamdy Mona Mohamed
Published: January 2021

Background

Hearing is commonly impaired in Behçet’s disease (BD). Also, vestibular abnormalities as well as cochlear function affection have been found. The inflammatory process which leads to BD may be the cause of vestibular frequency audiometry abnormalities in those patients. The aim of this study is to assess hearing and vestibulo-colic reflex in Behçet patients using convential pure-tone audiometry (cPTA), high-frequency audiometry (HFA), and cervical vestibular evoked myogenic potential (cVEMP).

Results

This study included 25 patients with BD (group I), whose age ranged from 21 to 45 years, with a mean age of 34.24 ± 7.07 years. The control group (group II) comprised 20 normal adults whose ages are between 21 and 45 years, with a mean age of 30.8 ± 8.02 years. The measured cVEMP parameters which include the mean peak latency of P13 and the mean peak latency of N23 were statistically significantly different between the patients suffering from BD and the control groups. All BD patients had high-frequency sensorineural hearing loss (SNHL) starting from 4 up to 12.5 kHz. The mean thresholds of the audiometry were significantly higher in the diseased group.

Conclusion

cVEMP testing can be used for the evaluation of the vestibulo-colic reflex in BD patients. The occurrence of hearing loss especially in high-frequency regions is a common finding in patients suffering from BD, and a HFA may be a valuable tool in early exploration of hearing loss in patients with BD.
The paradoxical effect of COVID-19 outbreak on loneliness
Authors: Bartrés-Faz David , Macià Dídac , Cattaneo Gabriele , Borràs Roger , Tarrero Clara , Solana Javier , Tormos José M. , Pascual-Leone Alvaro
Published: January 2021

As in previous periods of quarantine, lockdown confinement measures dictated to control SARS-CoV-2 would be expected to negatively affect mental health. We investigated the immediate effects (over a 10 day period) of a strict nationwide stay-at-home order imposed in Spain, one of the countries most affected by the COVID-19 pandemic. Focusing our analysis on the feelings of loneliness, we obtained our measures within a social context characterised by strong and continuous public and governmental support for increasing social bonds and cooperation in order to face the common public threat. Leveraging data from the Barcelona Brain Health Initiative, a prospective population-based study cohort, the short UCLA Loneliness Scale was administered to 1604 participants 2 years and 1 year before the stay-at-home lockdown and repeated, on average, 10 days after the official confinement order issued by the Spanish government. Ratings of loneliness remained stable during the 2 years before lockdown; however, they decreased significantly during the early stages of home confinement. This effect was particularly significant for the item ‘feeling excluded from others’ and was also observed among individuals who were confined alone. Overall, the results suggest that gestures and manifestations of appreciation by people for the labour and efforts of certain individuals, along with official campaigns designed to promote feelings of inclusion and belonging, may have beneficial effects on feelings of loneliness, a negative emotional state strongly regarded as a risk factor for impaired mental and general health status. Further assessments during the later stages of home confinement are now warranted.
Risk of adverse outcome of COVID-19 among patients in secure psychiatric services: observational cohort study
Authors: Basrak Natasa , Mulcrone Naoise , Sharifuddin Sue , Ghumman Zeshan , Bechan Nirvana , Mohamed Enas , Murray Michael , Rajendran Hariharan , Gunnigle Sean , Nolan Mark , Quane Tim , Terao Masashi , Hoare Tracey , Kirrane Kevin , Kennedy Harry G. , Davoren Mary
Published: January 2021

Background

Secure forensic mental health services treat patients with high rates of treatment-resistant psychoses. High rates of obesity and medical comorbidities are common. Population-based studies have identified high-risk groups in the event of SARS-CoV-2 infection, including those with problems such as obesity, lung disease and immune-compromising conditions. Structured assessment tools exist to ascertain the risk of adverse outcome in the event of SARS-CoV-2 infection.

Aims

To assess risk of adverse outcome in the event of SARS-CoV-2 infection in a complete population of forensic psychiatry patients using structured assessment tools.

Method

All patients of a national forensic mental health service (n = 141) were rated for risk of adverse outcome in the event of SARS-CoV-2 infection, using two structured tools, the COVID-Age tool and the COVID-Risk tool.

Results

We found high rates of relevant physical comorbidities. Mean chronological age was 45.5 years (s.d. = 11.4, median 44.1), mean score on the COVID-Age tool was 59.1 years (s.d. = 19.4, median 58.0), mean difference was 13.6 years (s.d. = 15.6), paired t = 10.9, d.f. = 140, P < 0.001. Three patients (2.1%) were chronologically over 70 years of age, compared with 43 (30.5%) with a COVID-Age over 70 (χ2 = 6.99, d.f. = 1, P = 0.008, Fisher's exact test P = 0.027).

Conclusions

Patients in secure forensic psychiatric services represent a high-risk group for adverse outcomes in the event of SARS-COV-2 infection. Population-based guidance on self-isolation and other precautions based on chronological age may not be sufficient. There is an urgent need for better physical health research and treatment in this group.
Anal Adenocarcinoma: A Rare Malignancy in Need of Multidisciplinary Management
Authors: Lukovic Jelena , Kim John J. , Krzyzanowska Monika , Chadi Sami A. , Taniguchi Cullen M. , Hosni Ali
Published: January 2021

Adenocarcinoma of the anal canal is an uncommon malignancy, making it challenging to perform randomized controlled clinical trials to define best practices in care. For patients with localized disease, there remains a lack of consensus regarding the optimal management, with some physicians advocating for trimodality therapy (similar to the locally advanced rectal adenocarcinoma paradigm) and others advocating for definitive radiation therapy with concurrent chemotherapy (similar to the management of anal squamous cell carcinoma). The objective of this clinical review is to describe the management and outcomes of patients with anal adenocarcinoma to help inform treatment recommendations.
Influence of Particle Size and Drug Load on Amorphous Solid Dispersions Containing pH-Dependent Soluble Polymers and the Weak Base Ketoconazole
Authors: Monschke Marius , Kayser Kevin , Wagner Karl G.
Published: January 2021

Among the great number of poorly soluble drugs in pharmaceutical development, most of them are weak bases. Typically, they readily dissolve in an acidic environment but are prone to precipitation at elevated pH. This was aimed to be counteracted by the preparation of amorphous solid dispersions (ASDs) using the pH-dependent soluble polymers methacrylic acid ethylacrylate copolymer (Eudragit L100–55) and hydroxypropylmethylcellulose acetate succinate (HPMCAS) via hot-melt extrusion. The hot-melt extruded ASDs were of amorphous nature and single phased with the presence of specific interactions between drug and polymer as revealed by X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), and Fourier-transform infrared spectroscopy (FT-IR). The ASDs were milled and classified into six particle size fractions. We investigated the influence of particle size, drug load, and polymer type on the dissolution performance. The best dissolution performance was achieved for the ASD made from Eudragit L100–55 at a drug load of 10%, whereby the dissolution rate was inversely proportional to the particle size. Within a pH-shift dissolution experiment (from pH 1 to pH 6.8), amorphous-amorphous phase separation occurred as a result of exposure to acidic medium which caused markedly reduced dissolution rates at subsequent higher pH values. Phase separation could be prevented by using enteric capsules (Vcaps Enteric®), which provided optimal dissolution profiles for the Eudragit L100–55 ASD at a drug load of 10%.
Cross-Coupling Reactions of Persistent Tertiary Carbon Radicals
Authors: Sohtome Yoshihiro , Kanomata Kyohei , Sodeoka Mikiko
Published: January 2021

The scope of cross-coupling reactions using tertiary carbon-centered radicals has expanded rapidly over the past decade. In this review, we outline the development of the cross-coupling reactions that involve persistent tertiary carbon-centered radicals as a powerful toolbox to synthesize molecules containing quaternary carbon(s) and/or tetra-substituted carbon(s). In particular, we focus on persistent tertiary carbon-centered radicals derived from carbonyl- or related compounds. We first describe the historical background and structural characterization of these radicals, and their reactivity/selectivity relationships. We then present selected recent examples of cross-coupling reactions involving tertiary carbon-centered radicals, categorized according to the originally proposed reaction mechanism, to showcase their versatile synthetic utility for structural diversification of small molecules.
PI3K inhibition as a novel therapeutic strategy for neoadjuvant chemoradiotherapy resistant oesophageal adenocarcinoma
Authors: Edge Sarah D , Renard Isaline , Pyne Emily , Li Chun , Moody Hannah , Roy Rajarshi , Beavis Andrew W , Archibald Stephen J , Cawthorne Christopher J , Maher Stephen G , Pires Isabel M
Published: January 2021

Objective:

Neoadjuvant chemoradiotherapy (neo-CRT) prior to surgery is the standard of care for oesophageal adenocarcinoma (OAC) patients. Unfortunately, most patients fail to respond to treatment. MiR-187 was previously shown to be downregulated in neo-CRT non-responders, whist in vitro miR-187 overexpression enhanced radiosensitivity and upregulated PTEN. This study evaluates the role of miR-187 and downstream PI3K signalling in radiation response in OAC.

Methods:

The effect of miR-187 overexpression on downstream PI3K signalling was evaluated in OAC cell lines by qPCR and Western blotting. PTEN expression was analysed in OAC pre-treatment biopsies of neo-CRT responders and non-responders. Pharmacological inhibition of PI3K using GDC-0941 was evaluated in combination with radiotherapy in two-dimensional and three-dimensional OAC models in vitro and as a single agent in vivo. Radiation response in vitro was assessed via clonogenic assay.

Results:

PTEN expression was significantly decreased in neo-CRT non-responders. MiR-187 overexpression significantly upregulated PTEN expression and inhibited downstream PI3K signalling in vitro. GDC-0941 significantly reduced viability and enhanced radiation response in vitro and led to tumour growth inhibition as a single agent in vivo.

Conclusion:

Targeting of PI3K signalling is a promising therapeutic strategy for OAC patients who have repressed miR-187 expression and do not respond to conventional neo-CRT.

Advances in knowledge:

This is the first study evaluating the effect of PI3K inhibition on radiosensitivity in OAC, with a particular focus on patients that do not respond to neo-CRT. We have shown for the first time that targeting of PI3K signalling is a promising alternative therapeutic strategy for OAC patients who do not respond to conventional neo-CRT.
Optimization of catheter placement for convection-enhanced delivery to brain tumors
Authors: Antoine Lisa H. , Koomullil Roy P. , Wick Timothy M. , Nakhmani Arie
Published: January 2021

Background:Recent trends suggest that physicians will diagnose thousands of children in the United States with a brain or central nervous system tumor in 2020. Malignant brain tumors are difficult to treat, with low life expectancy rates in children and adults. Convection-enhanced delivery (CED) shows promise for the treatment of brain tumors, yet remains in clinical trials despite being developed more than 20 years ago. To advance CED to standard of care status and help improve survival rates, this study group developed a quantitative computer simulation model to determine and optimize therapy distribution in brain tumors based on the catheter infusion locations for CED.

Methods:The simulations resulted in the identification of four infusion reference locations, which were used to conduct an optimization study to identify the optimal locations for CED. Patient-specific T1-weighted images and diffusion-weighted images provided information regarding tumor shape and size and the approximate rate at which therapy distributes at spatial locations within the tumor. Using the images, the researchers in this study developed a model which allowed the calculation of therapy distribution within the tumor while considering its permeability, porosity, and interstitial fluid pressure characteristics. We divided the tumor into regions and calculated distribution for four infusion locations per region. Using the location from each region with the highest volume distribution allowed our study group to conduct the response surface optimization.

Results:Twelve optimal locations emerged from the optimization with volume percentage distributions ranging from 7.92% to 9.09%, compared to 2.87% to 6.32% coverage for non-optimal locations. This optimization method improved distribution from 27.80% to 45.95%, which may improve therapeutic value.

Conclusions:Catheter placement appears to influence volume therapy distribution percentages. The selection of the highest percentages per region may provide optimal therapy for the entire tumor region.
Therapeutic implications of statins in heart failure with reduced ejection fraction and heart failure with preserved ejection fraction: a review of current literature
Authors: Techorueangwiwat Chol , Kanitsoraphan Chanavuth , Hansrivijit Panupong
Published: January 2021

Statins are one of the standard treatments to prevent cardiovascular events such as coronary artery disease and heart failure (HF). However, data on the use of statins to improve clinical outcomes in patients with established HF remains controversial. We summarized available clinical studies which investigated the effects of statins on clinical outcomes in patients with HF with reduced ejection fraction (HFrEF) and HF with preserved ejection fraction (HFpEF). Statins possess many pleiotropic effects in addition to lipid-lowering properties that positively affect the pathophysiology of HF. In HFrEF, data from two large randomized placebo-controlled trials did not show benefits of statins on mortality of patients with HFrEF. However, more recent prospective cohort studies and meta-analyses have shown decreased risk of mortality as well as cardiovascular hospitalization with statins treatment. In HFpEF, most prospective and retrospective cohort studies as well as meta analyses have consistently reported positive effects of statins, including reducing mortality and improving other clinical outcomes. Current evidence also suggests better outcomes with lipophilic statins in patients with HF. In summary, statins might be effective in improving survival and other clinical outcomes in patients with HF, especially for patients with HFpEF. Lipophilic statins might also be more beneficial for HF patients. Based on current evidence, statins did not cause harm and should be continued in HF patients who are already taking the medication. Further randomized controlled trials are needed to clarify the benefits of statins in HF patients.
How to Motivate the Russian Researcher to High Scientific Achievements?
Authors: Rimskaya O. , Kranbihler V.
Published: January 2021

The increasing competition in world markets, the development of high-tech industries based on the latest scientific achievements entail additional innovations to maintain a competitive level of goods, works and services, and to accelerate scientific and technological progress. To achieve results and economic growth in the context of sanctions, the state and large companies need to form new principles of personnel management and systematically stimulate scientific activity. The authors have proposed criteria for evaluating the results of scientific activities in order to stimulate the efforts of scientists financially by setting a premium for their scientific degree. Unlike university professors, scientists in industry do not receive guaranteed allowance. The mechanism of formation of the allowance is based on the fulfillment of a set of criteria and has not only a stimulating function, but also a strategic one - increasing the publication activity of employees and creating an innovative image of the organization through the accumulation of scientific potential. The mechanism is especially relevant for innovative enterprises of high-tech industries in Russia.
Un nuevo enfoque del marketing social en las redes sociales. Aplicación en las ONGD
Authors: Galiano-Coronil Araceli
Published: January 2021

Social networks represent important communication tools that have not gone unnoticed by Development NonGovernmental Organisations (DNGOs). An appropriate management, a use, and the monitoring can increase the visibility of these organisations and therefore improve their results. There are various scientific studies on specific aspects related to these tools and their application by NGDOs such as their use or effectiveness.
The importance of the communication strategy in tourism micro-enterprises in Seville
Authors: Corona-León Gladys Arlette , Mancinas-Chávez Rosalba
Published: January 2021

In the context of excess information that we live in the XXI century, institutional communication becomes essential. Big enterprises and institutions clearly see the need to invest in this aspect, however small and micro-enterprises do not have it so assumed. The aim of this paper is to analyze the role of institutional communication in tourist micro-enterprises in Seville. It is carried out from the interview with 6 managers of micro-enterprises and is complemented by 2 interviews with experts. From the results, it is possible to verify that the organizations that implement communication elements manage to position themselves better.
Shrinking the Upper Confidence Bound: A Dynamic Product Selection Problem for Urban Warehouses
Authors: Jin Rong , Simchi-Levi David , Wang Li , Wang Xinshang , Yang Sen
Published: January 2021

The recent rising popularity of ultrafast delivery services on retail platforms fuels the increasing use of urban warehouses, whose proximity to customers makes fast deliveries viable. The space limit in urban warehouses poses a problem for such online retailers: the number of stock keeping units (SKUs) they carry is no longer “the more, the better,” yet it can still be significantly large, reaching hundreds or thousands in a product category. In this paper, we study algorithms for dynamically selecting a large number of products (i.e., SKUs) with top customer purchase probabilities on the fly, from an ocean of potential products to offer on retailers’ ultrafast delivery platforms. We distill the product selection problem into a semibandit model with linear generalization. There are in total N arms corresponding to N products, each with a feature vector of dimension d. The player pulls K arms in each period and observes the bandit feedback from each of the pulled arms. We focus on the setting where K is much greater than the number of total time periods T or the dimension of product features d. We first analyze a standard Upper Confidence Bound (UCB) algorithm and show its regret bound can be expressed as the sum of a T-independent part and a T-dependent part, which we refer to as “fixed cost” and “variable cost,” respectively. To reduce the fixed cost for large K values, we propose a novel online learning algorithm, which iteratively shrinks the upper confidence bounds within each period, and show its fixed cost is reduced by a factor of d. Moreover, we test the algorithms on an industrial data set from Alibaba Group. Experimental results show that our new algorithm reduces the total regret of the standard UCB algorithm by at least 10%.

This paper was accepted by J. George Shanthikumar, big data analytics.
As muitas formas de pensar o cuidado em nossa sociedade
Authors: Da Costa Valério Quagliato Henrique
Published: January 2021

TAMANINI, Marlene et al. O Cuidado em Cena: Desafios políticos, teóricos e práticas. v. 1. Florianópolis: UDESC, 2018. 380 p. v. 1. ISBN 978-858302-141-1.
Ordenar la casa. Securitización, jerarquización y regulación del espacio urbano en la política de Cambiemos en La Plata (2015-2019)
Authors: Segura Ramiro , Vélez Joaquín
Published: January 2021

O artigo discute a política urbana de Cambiemos na cidade de La Plata, capital da província de Buenos Aires, durante o período 2015-2019. La Plata. Você está em casa foi o slogan de governança desta coalizão política de direita que implementou um conjunto de políticas urbanas destinadas a “ordenar a (cidade como) casa”. A partir de um diagnóstico decadente do estado da cidade difundido entre as classes média e alta, bem como um imaginário urbano em relação à deve ser a cidade, a política de securitização de Cambiemos operava como um poderoso dispositivo de hierarquia e regulação do espaço urbano. Combinando repressão, policiamento e prevenção, essas políticas buscavam regular quem pode fazer o que, onde e quando, e envolveu o deslocamento, marginalização e/ou expulsão de práticas e pessoas informais (feirantes, vendedores nas ruas, prostituição, centros culturais, entre outros) para gerar condições de investimento urbano. Em suma, foi a implantação do urbanismo “revanchista” e “autoritário” que, em nome da segurança e prevenção, implementou o modelo de “a cidade como casa”, regulando, deslocando e até expulsando o que é considerado “fora do lugar”. Quem (não) entra em casa? A imagem da cidade como casa tem afiliações políticas conservadoras e abre questões fundamentais sobre à vida urbana democrática, como liberdade de acesso, condições iguais, direito a (in)diferença, e possibilidades de diálogo e dissidência em espaços que, por definição, constituem áreas de encontro entre diferentes e desiguais.
Migrações e Diversidade na Cidade Empreendedora: Definindo o cenário para os novos imaginários urbanos
Authors: Oliveira Nuno
Published: January 2021

A partir de trabalho de campo em Lisboa e Buenos Aires, o artigo examina como os processos de regeneração e revitalização do centro da cidade têm sido consistentemente ligados à mobilização da diversidade cultural. A pesquisa etnográfica e qualitativa foi realizada em espaços urbanos específicos onde a regeneração dirigida pela cultura se encontra a ser levada a cabo . A seleção desses espaços foi baseada na ideia de evitar os suspeitos usuais em estudos urbanos, como as grandes capitais do hemisfério norte. Argumentamos que os traços culturais dos imigrantes são trazidos para esses processos por meio de mecanismos mediadores específicos dos modelos das cidades empreendedoras. Integramos em nossa análise uma ampla gama de atores envolvidos na governança urbana, desde autoridades municipais, passando por organizações de imigrantes, até empreendedores migrantes, a fim de fornecer uma interpretação completa de tais mecanismos. Mostramos que as cidades buscam estratégias similares de lidar com a diversidade cultural de origem imigrante, estando nestas implicadas três dimensões principais: estetização, marketing de lugar e “ethnic showcasing”. Levantamos algumas questões conceituais e políticas relacionadas com os novos regimes de visibilidade e formas de organização social da diferença específicas da cidade empreendedora.
Problemas de patrimônio como problemas de gênero: disjunções entre feminismo e cultura popular na Festa de Santo Antônio em Barbalha (CE)
Authors: Marques Roberto
Published: January 2021

O artigo analisa disjunções e conjunções existentes entre as ações dos feminismos no Cariri e o imaginário espacial que modula a patrimonialização da Festa do Pau de Bandeira de Santo Antônio, na cidade de Barbalha (CE). No ano de 2019, durante o cortejo de grupos de cultura popular que antecede a Festa do Pau da Bandeira, aconteceu a sexta Marcha das Mulheres. Ao longo do percurso, participantes da marcha foram continuamente interpeladas por representantes da organização institucional da Festa. A ação dos organizadores acionava formas de localização do movimento de mulheres, uma compreensão nativa dos debates sobre gênero e sobre a cultura popular naquela manifestação. Pensamos a expressão desse conflito social como disputa entre diferentes projetos para a região do Cariri cearense, para os debates sobre gênero e para a vida das mulheres na região. A patrimonialização da Festa e seus personagens acessam uma romantização do mundo rural incompatível com a denúncia da morte de mulheres na região do Cariri pelos feminismos locais, embora ambas as narrativas estejam conectadas à ideia de um Brasil rural, atávico, distante da cidadania e urbanidade. As fricções ocorridas na Festa de Santo Antônio relembram, portanto, imagens que circulam em momentos em que grupos à margem do imaginário nacional brasileiro empunham símbolos diacríticos das ideias de participação política e memória nacional. Tensões acessadas como clichês de uma utopia generalizante de abrigo à diversidade de demandas compostas pela e para a nação.
Análise funcional da construção conectora contrastiva “mas olha”
Authors: Rosário Ivo Costa , Sambrana Vania Rosana Mattos
Published: January 2021

Este artigo tem como objetivo principal investigar o uso da construção conectora “mas olha” no âmbito das relações discursivas do português contemporâneo. Com base nos pressupostos teórico-metodológicos da Linguística Funcional Centrada no Uso, com apoio na Gramática de Construções e nos estudos de coesão textual, analisamos ocorrências de “mas olha” pelo prisma da construcionalidade, em perspectiva sincrônica, como demonstrado em xxx (2019). Os dados são captados em blogues brasileiros do século XXI. Por meio de metodologia qualitativa, a análise dos contextos de uso permite a conclusão de que essa construção conectora foi formada por meio de chunking e de neoanálises sintática e semântica a partir de dois marcadores discursivos pré-existentes. No português, “mas olha” revela-se como um conector marginal, tendo em vista suas propriedades de uso no contexto de relações macrossintáticas, que extrapolam o âmbito do tradicional período composto. Em termos funcionais, atua na coesão sequencial entre proposições no campo das relações contrastivas, especialmente no nível do modus.
Evento de movimento transitivo: uso e cognição
Authors: Cunha Maria Angélica Furtado da , César Alan Marinho
Published: January 2021

Este artigo focaliza a codificação semântico-sintática da construção de movimento transitivo, com o objetivo de tratar da relação entre o tipo de evento expresso pela construção e os esquemas cognitivos por ela acionados. A base teórica que fundamenta este trabalho conjuga a Linguística Funcional Centrada no Uso, a Linguística Cognitiva e a Gramática de Construções, investigando aspectos estruturais, semânticos, funcionais e cognitivos presentes nas instanciações dessa construção. Os dados empíricos foram coletados de fontes diversas: o Corpus Discurso & Gramática, o Banco de Sentenças da Justiça Federal do Rio Grande do Norte, o Banco de Dados do Programa de Estudos Sobre o Uso da Língua da UFRJ e textos disponíveis online em sites de revistas de ampla circulação. Os resultados da pesquisa revelam a existência de um esquema construcional que sanciona três subesquemas e sete microconstruções que, por sua vez, revelam noções de movimento causado, movimento percorrido e movimento associado. Da perspectiva sintático-semântica, a codificação linguística do evento de movimento transitivo projeta frames que manifestam diferentes tipos de movimento, como manipulação, transporte e deslocamento; em termos de estrutura cognitiva, os esquemas imagéticos apontam o traço focalizado do trajeto.
The importance of upholding the duty of candour during patient care
Authors: Glasper Alan
Published: January 2021

In light of recent media coverage, Emeritus Professor Alan Glasper, from the University of Southampton, discusses polices and guidance pertinent to the duty of candour
Covid-19 vaccination: Logistical challenges for general practice
Authors: Butt Mike
Published: January 2021

With the UK's Covid-19 vaccine roll out now under way, the arrival of a potentially life-saving jab is no longer a dream. However, the scale of the logistical challenge posed by the roll-out should not be underestimated
DNAR orders during the pandemic
Authors: Halliwell Amanda
Published: January 2021

The Care Quality Commission was commissioned by the Department of Health and Social care to review do not attempt resuscitation decision-making during the Covid-19 pandemic. Amanda Halliwell reviews their interim report
Dealing with aggressive patients in the practice
Authors: Devlin Clare
Published: January 2021

Managing aggressive patients is something that challenges a practice at the best of times. Dr Clare Devlin, Medicolegal Consultant at Medical Protection, offers advice on handling difficult situations
Babies' and young children's needs ‘forgotten’
Authors: Moffat Polly
Published: January 2021

Findings from an annual survey of health visitors reveal the damage the pandemic has done to the young and vulnerable
In-Vitro Evaluation of Antibacterial, Antifungal and Anti-HIV Effects of Calophyllum inophyllum Leaf Extract
Authors: Kumar Arun , Garg Yashika
Published: January 2021

Background:Calophylluminophyllum is an evergreen tree with ethno-medical value growing along the seashores and islands of the Pacific and Indian Ocean. All parts of the plant such as bark, seeds and leaves have diverse medicinal uses such as an antiseptic, analgesic in wound healing, astringent, diuretic, purgative and expectorant. Although many species of calophyllum have been studied phytochemically for pharmacological properties, reports on inophyllum species are scanty. Aim of the study:Keeping inview it’s medical importance and availability in India as well as the rapid development of resistance by pathogens to the commonly used synthetic antibiotics,the pharmacological effects of C. inophyllum leaf extract (CIE) on HIV, bacteria and fungi causative of many human diseases was assessed in this study. Material and Methods: Isolation of the pure compounds from the ethanolic CIE was performed by gross column chromatography and tested against lyophilized forms of 8 fungal and 14 bacterial strains grown on Sabouraud’s dextrose agar and nutrient agar media respectively. Fractions and pure compounds isolated from CIE were evaluated against HIV by the HIV-RT inhibition assay by using the RT assay kit(Roche). The results were tabulated and analysed. Results: Among the purified compounds, Inophyllum C & E exhibited significant antibacterial and antifungal properties. Moreover, Inophyllum E was more potent than Inophyllum C in inhibiting the tested strains of bacteria and fungi whereasInophyllum B shows highest antiretroviral activity. Conclusion:We conclude that CIEis aneffective antimicrobial agent against common human pathogens tested in this in-vitro pharmacological evaluation of CIE.
The Effects of Vitamin B Combination Injection on Lymphocyte Count in Chronic Kidney Failure Patients
Authors: Pinzon Rizaldy Taslim , Veronica Vanessa , Dian-Christi Yohana Ratih Tirtaningtyas , Pradani Regina Ayudyaningsari
Published: January 2021

Background: Chronic kidney failure will lead to decline in immune system. Vitamin B considered has essential roles in immune system, including lymphocyte count. Aims: Measure the effects of vitamin B combination injection on lymphocyte count in chronic kidney failure patients. Methods: This was quasi-experimental study with one group pretest-posttest design from the period of August 2018 - October 2018 at Bethesda Hospital and Panti Rapih Hospital, Yogyakarta, Indonesia. Subjects received vitamin B combination injection (intravenous) after each hemodialysis. Lymphocyte count were measured 3 times namely visit I (before first hemodialysis), visit II (after second hemodialysis), and visit III (after third hemodialysis). Results: The data were obtained from 115 chronic kidney failure patients, consist of 75 male and 40 female. The most common age group in this study was 40-59 years old. There were no significant improvements of lymphocyte counts, both on visit II compared to visit I (1285.713±475.9829/mm3 vs 1504.219±1148.974/mm3; p: 0.065) as well as visit III compared to visit I (1285.713±475.9829/mm3 vs 1315.192±658.6673/mm3; p: 0.766). Conclusion: Vitamin B combination injection has no significant effects on lymphocyte count in chronic kidney failure patients. Intravenous vitamin B was safe for chronic kidney failure patients.
The Formation of Social Skills in Children with Down Syndrome Under the Influence of Regular Football
Authors: Makhov Alexander S. , Kazakov Dmitry A. , Seselkin Alexey I. , Kartashev Valery P. , Karpova Natalia V. , Mishanina Natalya V.
Published: January 2021

People with down syndrome, is very difficult to socialize due to significant communication difficulties. It is difficult to give any of the organizational actions in your daily life. To solve these problems so people recommend sports activities, which contribute to the development of many necessary for living in society skills – punctuality, neatness, discipline and diligence. Very suitable in this case the sport is football. This is a team sport that can generate team spirit, sense of camaraderie, mutual support, creating the basis for rapid adaptation in the team. So, in football, people with down syndrome, become healthier, active socializers, develop their talents and become more sociable. The analysis of the views of parents of children with down syndrome showed a high significance of sport in their child's life. This section, such children get valuable experience. Here they take an example and try to be polite. Sports activity socialize a child gives you the opportunity to prove himself as an athlete and help them overcome internal barriers. Sports trigger in children with down syndrome the physical and psychological indicators. According to parents, it is football changing the lives of their child in a better way children adapt to life in the team, reveal their mental capacity, making whiter confident and more disciplined.
Therapeutic Adherence among Elderly with Chronic Diseases Residing in Urban Area of South India – A Descriptive Cross Sectional Study
Authors: Angadi Netravathi Basavaraj , Kavi Avinash , Torgal Shashikant Shankreppa
Published: January 2021

Non-communicable diseases (NCDs) are no longer confined to urban and rich persons. They impose a great risk in the low-income nations due to epidemiological and demographic transition. Adherence to medication is key factor in improving the quality of life and preventing complications of NCDs. This study was carried out to study the prevalence of medication adherence and factors determining non-adherence in elderly population with chronic diseases. A community based cross sectional study was conducted with 400 elderly aged 60 years and above. Data was collected by using a pretested questionnaire, which included socio-demographic variables, co-morbidities and details of their medication. Therapeutic adherence was assessed by modified Morisky-Green test, level of cognitive impairment by Pfeiffer’s short portable mental status questionnaire and functional dependence in activities of daily living by Katz Index. Statistical analysis was done using chi-square test. In our study, out of 400 participants, male participants were 184 (48%) and female participants were 216 (52%). 58.5% of them were adherent to their respective treatment medication. Male gender, low level of education, lower socio-economic status and cognitive impairment were the factors associated with therapeutic non-adherence. Therapeutic non-adherence is highly prevalent among elderly persons and is multi-factorial in origin. Interventions to increase adherence among elderly might effective if they are provided with proper guidance and education on the indications of individual treatments, their adverse effects, importance of adherence to medications and various consequences of non-adherence to the therapy.
Single-Shot Ptychographic Imaging of Femtosecond Laser Induced Plasma Dynamics
Authors: Barolak Jonathan , Goldberger David , Durfee Charles , Adams Daniel
Published: January 2021

We present, to our knowledge, the first Single-Shot Ptychographic imaging of a continuously dynamic object. We also present the first ptychographic imaging of a plasma induced event created from a femtosecond laser breakdown in air.
Ultrabright photoluminescence spikes from 100-nm colloidal silver nanocubes for patch nanoantennas
Authors: Lukishova Svetlana G. , Brone Jerome , Mei Jiwei , Young Liam , Khan Darman , Li Zihao
Published: January 2021

Ultrabright intensity spikes (up to ~400─900 kcounts/s) appear sporadically in time traces of photoluminescence from 100-nm silver nanocubes (used in patch nanoantennas for single-photon source applications) under 532 or 633 nm laser excitation.
Deep-learning Accelerated Fringe Pattern Filtration Using Variational Image Decomposition
Authors: Cywińska Maria , Trusiak Maciej , Patorski Krzysztof
Published: January 2021

Using a deep convolutional neural network we accelerated our unsupervised variational image decomposition algorithm making it not only automatic, robust and accurate but also fast. Reduction of computation time is nearly 90%.
In-system optimization of hologram for high-stability parallel laser processing
Authors: Zhang Honghao , Hasegawa Satoshi , Takahashi Hidetomo , Toyoda Haruyoshi , Hayasaki Yoshio
Published: January 2021

A new method that a computer-generated hologram optimization is continuously performed during laser fabrication is proposed. The uniformity of 36 parallel beams was improved to more than 98% by exploiting the rewritable capability of the spatial light modulator.
A super-resolution planar lens with binary phase modulation using particle swarm optimization algorithm
Authors: Zhu Zhaoxiang , Zheng Pengcheng , He Lin , Lin Zhongzheng , Xie Xiangsheng , Chen Yujie , Yu Siyuan
Published: January 2021

We design a plane lens with binary phase modulation for linearly polarized light using the combined vector angular spectrum and binary particle swarm optimization algorithm (PSO), targeting for breaking the diffraction limit.
Doubly Resonant Second Harmonic Generation in Photonic Crystal Cavities via Bound States in the Continuum
Authors: Clementi Marco , Barone Andrea , Wang Jun , Minkov Momchil , Carlin Jean-François , Grandjean Nicolas , Fan Shanhui , Houdré Romuald , Gerace Dario , Galli Matteo
Published: January 2021

We experimentally demonstrate doubly resonant second harmonic generation in gallium nitride photonic crystal cavities. The second harmonic mode is confined via a bound state in the continuum, which yields a radially polarized vortex beam.
Structuring the Complex Lattices by Tailoring Phase and Polarization
Authors: Ruchi  , Senthilkumaran Paramasivam
Published: January 2021

Fundamental properties of light viz, amplitude, phase, and polarization can be tailored to generate structured light. Here, we study complex lattice structures and investigate the underlying relationship between phase and polarization engineering.
PON Monitoring Technique Based on 2D Encoders and Wavelength-to-Time Mapping
Authors: Fernández Manuel P. , Costanzo Caso Pablo A. , Bulus Rossini Laureano A. , Cruz José L. , Andrés Miguel V.
Published: January 2021

A PON monitoring technique is demonstrated based on an OTDR-like device and FBG-encoders having a unique combination of central wavelength and reflection bandwidth. This results in more compact and cost-efficient encoders than previous proposals.
Efficient MoTe2 Slot-enhanced Photodetector based on Engineering Gain-Bandwidth-Product Scaling Laws
Authors: Wang H. , Ma Z. , Maiti R. , Miscuglio M. , Sorger V. J.
Published: January 2021

Here we demonstrate an efficient (0.8 AW-1) plasmonic slot photodetector based on monolithically integrating MoTe2 in silicon photonics. Shrinking the source-drain distance (L) to 10 nm enables high gain-bandwidth-product detectors scaling with L^-2.
Dual Pump Photon Pair Generation with Suppression of Parasitic Processes in Linearly Uncoupled Silicon Resonators
Authors: Sabattoli F. A. , El Dirani H. , Youssef L. , Garrisi F. , Grassani D. , Zatti L. , Petit-Etienne C. , Pargon E. , Liscidini M. , Sciancalepore C. , Bajoni D. , Galli M.
Published: January 2021

We report on the generation of photon pairs through dual-pump four-wave-mixing in a system composed of two resonators coupled solely through a third-order nonlinear interaction, which allows for the suppression of parasitic nonlinear phenomena.
Characterization and Control of Spatial Quantum Correlations in Entangled Light Generated via Four-wave Mixing
Authors: Nirala Gaurav , Pradyumna Siva T. , Kumar Ashok , Marino Alberto M.
Published: January 2021

We show the presence of EPR spatial quantum correlations in macroscopic quantum light generated via four-wave mixing. Furthermore, we show that it is possible to gain control over the distribution of these correlations.
Optimal Imaging of Remote Bodies Using Quantum Detectors
Authors: Howard L. A. , Gillett G. G. , Pearce M. E. , Abrahao R. A. , Weinhold T. J. , Kok P. , White A. G.
Published: January 2021

We implement an optimal imaging method using number-resolving photon detectors. Measuring the complex degree of coherence, we obtain the size and position of a distant pseudothermal light source and show this method outperforms traditional imaging.
Parametric amplifier for Bell measurement in continuous-variable quantum state teleportation
Authors: Chen Xin , Ou Z. Y.
Published: January 2021

We discuss the parametric amplifier as a replacement for the beam splitter in the Bell measurement in continuous-variable quantum state teleportation. It shows the advantage of loss-tolerance in the process.
Transverse beam shape of laser-driven electron bunches
Authors: Le M. , Salehi F. , Railing L. , Pascale L. , Milchberg H. M.
Published: January 2021

We observe the acceleration of electron bunches with a Lorentzian transverse profile using few-cycle laser pulses focused on the downstream side of a near-critical hydrogen gas jet.
Charge Carrier and Lattice Carrier Dynamics from Temperature-Dependent Terahertz Spectroscopy
Authors: Sooriyagoda Rishmali , Piyathilaka Herath P. , Zawilski Kevin T. , Schunemann Peter G. , Bristow Alan D.
Published: January 2021

We demonstrate temperature-dependent refraction, absorption, electron-phonon coupling, AC conductivity and mobility in bulk chalcopyrite semiconductors using THz-TDs. The measured optical and electronic properties are significantly influenced by temperature that affects the underlying carrier scattering mechanism.
InSb-based THz Plasmonic Array with High Resonances
Authors: Aghili Sina , Amini Aydin , Dolgaleva Ksenia
Published: January 2021

We designed a periodic plasmonic array based on InSb metamolecules that features narrow resonances at the THz range. Using FDTD simulations, we analyzed localized and surface lattice resonances of the structure.
Diffractive-Plasmonic Reflective Color Filters with Asymmetric Viewing Angles
Authors: Melo Emerson G. , Ribeiro Ana L. A. , Benevides Rodrigo , Zuben Antônio A. G. V. , Santos Marcos V. P. , Silva Alexandre A. , Wiederhecker Gustavo S. , Alegre Thiago P.M.
Published: January 2021

The color viewing angles of diffractive-plasmonic reflective color filters are assessed using BFP microscopy images and numerical simulations. The results indicate an asymmetric color response useful for data privacy enhancement in display applications.