bluuebunny/crossref_metadata_2025 huggingface dataset:
.rprofile: Julia Stewart Lowndes
Authors: Kross Sean , O'Briant Kelly
Published: September 2023

[This interview occurred at the 2017 rOpenSci unconference] SK: I’m Sean Kross, I’m the CTO of the Johns Hopkins Data Science Lab. Today I’m interviewing Julia Stewart Lowndes. Julia, what is your current preferred job title? JSL: I’m calling myself a marine data scientist - I’m the Science Program Lead for the Ocean Health Index.
23. bis 29. Oktober: International Open Access Week 2023 „Community over Commercialization“
Authors: Fischer Georg
Published: September 2023

Veranstaltungen in Berlin und Brandenburg bei diesjährigen #OAWeek
.rprofile: Karthik Ram
Authors: O'Briant Kelly
Published: September 2023

[This interview occurred at the 2017 rOpenSci unconference] KO: What is your name, job title, and how long have you been using R? KR: My name is Karthik Ram I’m a research scientist at the University of California, Berkeley. I’m an ecologist by training but have been working in the ‘data science’ space for 15 years. My real introduction to R was during my PhD when I was a teaching assistant for an engineering class on data analysis.
5 Things I Learned Making a Package to Work with Hydrometric Data in R
Authors: Albers Sam
Published: September 2023

One of the best things about learning R is that no matter your skill level, there is always someone who can benefit from your experience. Topics in R ranging from complicated machine learning approaches to calculating a mean all find their relevant audiences. This is particularly true when writing R packages.
drake transformed
Authors: Landau Will
Published: September 2023

Version 7.0.0 of drake just arrived on CRAN, and it is faster and easier to use than previous releases.install.packages("drake")Recap Data analysis can be slow. A round of scientific computation can take several minutes, hours, or even days to complete. After it finishes, if you update your code or data, your hard-earned results may no longer be valid. How much of that valuable output can you keep, and how much do you need to update?
rOpenSci Educators Collaborative: What Educational Resources Work Well and Why?
Authors: Ación Laura , Averick Mara , Fournier Auriel , Hill Alison , Kross Sean , Mullen Lincoln
Published: September 2023

In the first post of this series, we sketched out some of the common challenges faced by educators who teach with R across scientific domains. In this post, we delve into what makes a “good” educational resource for teaching science with R. For instructors teaching sciences with R, there are a number of open educational resources that they can reuse, tailor to their own teaching style, or use to inspire them in creating their own materials.
Where to go observe birds in Radolfzell? An answer with R and open data
Authors: Salmon Maëlle , Padgham Mark
Published: September 2023

This post is the 1st post of a series showcasing various rOpenScipackages as if Maëlle were a birder trying to make the most of R ingeneral and rOpenSci in particular. Although the series use cases willmostly feature

birds

, it’ll be the occasion to highlight rOpenSci’spackages that are more widely applicable, so read on no matter what yourfield is! Moreoever, each post should stand on its own.
outcomerate: Transparent Communication of Quality in Social Surveys
Authors: Hellwig Rafael Pilliard
Published: September 2023

Background Surveys are ubiquitous in the social sciences, and the best of them are meticulously planned out. Statisticians often decide on a sample size based on a theoretical design, and then proceed to inflate this number to account for “sample losses”. This ensures that the desired sample size is achieved, even in the presence of non-response.
Announcing a New rOpenSci Software Review Collaboration
Authors: Salmon Maëlle , Ross Noam , Chamberlain Scott , Ram Karthik
Published: September 2023

rOpenSci is pleased to announce a new collaboration with the Methods in Ecology and Evolution (MEE), a journal of the British Ecological Society, published by Wiley press

1

. Publications destined for MEE that include the development of a scientific R package will now have the option of a joint review process whereby the R package is reviewed by rOpenSci, followed by fast-tracked review of the manuscript by MEE.
Mapping the 2018 East Africa floods from space with smapr
Authors: Joseph Max
Published: September 2023

Hundreds of thousands of people in east Africa have been displaced and hundreds have died as a result of torrential rains which ended a drought but saturated soils and engorged rivers, resulting in extreme flooding in 2018.This post will explore these events using the R package smapr, which provides access to global satellite-derived soil moisture data collected by the NASA Soil Moisture Active-Passive (SMAP) mission and abstracts away some of
Monkeying around with Code and Paying it Forward
Authors: Dobbyn Amanda
Published: September 2023

library(tidyverse)library(monkeylearn) This is a story (mostly) about how I started contributing to the rOpenSci package monkeylearn. I can’t promise any life flipturning upside down, but there will be a small discussion about git best practices which is almost as good 🤓. The tl;dr here is nothing novel but is something I wish I’d experienced firsthand sooner.
Our package reviews in review: Introducing a 3-post series about software onboarding data
Authors: Salmon Maëlle
Published: September 2023

On March the 17th I had the honor to give a keynote talk about rOpenSci’s package onboarding system at the satRday conference in Cape Town, entitled “Our package reviews in review: introducing and analyzing rOpenSci onboarding system”. You can watch its recording, skim through the corresponding slides or… read this series!What is rOpenSci onboarding?
Taking over maintenance of a software package
Authors: Chamberlain Scott , Salmon Maëlle , Ross Noam
Published: September 2023

Software is maintained by people. While software can in theory live on indefinitely, to do so requires people. People change jobs, move locations, retire, and unfortunately die sometimes. When a software maintainer can no longer maintain a package, what happens to the software? Because of the fragility of people in software, in an ideal world a piece of software should have as many maintainers as possible.
Unconf18 projects 2: middlechild, defender, ropsec, keybase
Authors: Ram Karthik
Published: September 2023

As part of our series summarizing all projects from this year’s unconf I’m excited to dive into all the security related offerings from this year.
Pdftools 2.0: powerful pdf text extraction tools
Authors: Ooms Jeroen
Published: September 2023

A new version of pdftools has been released to CRAN. Go get it while it’s hot:install.packages("pdftools") This version has two major improvements: low level text extraction and encoding improvements.About PDF textboxes A pdf document may seem to contain paragraphs or tables in a viewer, but this is not actually true.
Join, split, and compress PDF files with pdftools
Authors: Ooms Jeroen
Published: September 2023

Last month we released a new version of pdftools and a new companion package qpdf for working with pdf files in R. This release introduces the ability to perform pdf transformations, such as splitting and combining pages from multiple files. Moreover, the pdf_data() function which was introduced in pdftools 2.0 is now available on all major systems.Split and Join PDF files It is now possible to split, join, and compress pdf files with pdftools.
tinkr: editing Markdown documents using XML tools
Authors: Salmon Maëlle
Published: September 2023

Remember our recent post showing that one can wrangle Markdown filesprogrammatically without regex? Thattech note showed how to convert Markdown bodies to XML in order toextract information from them.
vcr: record and replay HTTP requests
Authors: Chamberlain Scott
Published: September 2023

R package test suites that include HTTP requests are dependent on an internet connection being up, the internet connection speed, changing behavior of the remote server, as well as changing response formats/data from a remote server. We ideally want to test functionality of our package relative to some known data that isn’t intermittently unavailable or changing.
How much work is onboarding?
Authors: Salmon Maëlle , Ross Noam
Published: September 2023

Our onboarding process, thatensures that packages contributed by the community undergo atransparent, constructive, non adversarial and open review process,involves a lot of work from many actors: authors, reviewers and editors;but

how much work

? Managing the effort involved in the peer-reviewprocess is a major part of ensuring its sustainability and quality.
What birds are observed near Radolfzell? Bird occurrence data in R
Authors: Salmon Maëlle
Published: September 2023

Thanks to the first post of theseries we knowwhere to observe birds near Radolfzell’s Max Planck Institute forOrnithology, so we could go and do that! Or we can stay behind ourlaptops and take advantage of eBird, afantastic bird sightings aggregator!
Announcing new software review editors: Anna Krystalli and Lincoln Mullen
Authors: Butland Stefanie
Published: September 2023

Part of rOpenSci’s mission is to create technical infrastructure in the form of carefully vetted R software tools that lower barriers to working with data sources on the web. Our open peer software review system for community-contributed tools is a key component of this. As the rOpenSci community grows and more package authors submit their work for peer review, we need to expand our editorial board to maintain a speedy process.
THOR’s last hurrah
Authors: Deane-Pratt Adèniké
Published: September 2023

Project THOR is coming to a close. Our final event was held in Italy on 15 November at ‘La Sapienza’ – the University of Rome – just a stone’s throw from Michelangelo’s impressive sculpture of Moses in the church of San Pietro in Vincoli. The day combined a retrospective review of THOR’s achievements and impact with a forward-looking perspective on the wider persistent identifier (PID) landscape.
What's this bird? Classify old natural history drawings with R
Authors: Salmon Maëlle
Published: September 2023

In this new post, we’re taking a break from modern birding data in ourbirder’s series… let’s exploregorgeous drawings from a natural history collection!
conditionz: control how many times conditions are thrown
Authors: Chamberlain Scott
Published: September 2023

conditionz is a new (just on CRAN today) R package for controlling how many times conditions are thrown.
The ssh Package: Secure Shell (SSH) Client for R
Authors: Ooms Jeroen
Published: September 2023

Have you ever needed to connect to a remote server over SSH to transfer files via SCP or to setup a secure tunnel, and wished you could do so from R itself? The new rOpenSci ssh package provides a native ssh client in R allows you to do that and even more, like running a command or script on the host while streaming stdout and stderr directly to the client.
When Standards Go Wild - Software Review for a Manuscript
Authors: Butland Stefanie , Golding Nick , Grieves Chris , Gruson Hugo , White Thomas , Ye Hao
Published: September 2023

Stefanie Butland,

rOpenSci Community Manager

Some things are just irresistible to a community manager – PhD student Hugo Gruson’s recent tweets definitely fall into that category.
rOpenSci Dev Guide 0.2.0: Updates Inside and Out
Authors: Salmon Maëlle , Anderson Brooke , Chamberlain Scott , Krystalli Anna , Mullen Lincoln , Ram Karthik , Ross Noam , Vidoni Melina
Published: September 2023

As announced in our recent post about updates to our Software Peer Review system, all our package development, review and maintenance is available as an online book. Our goal is to update it approximately quarterly so it’s already time to present its second official version!
Quản trị truyền thông của chính quyền địa phương trong bối cảnh cải cách hành chính nhà nước
Authors: Nguyễn Quỳnh Nga
Published: September 2023

Văn kiện Đại hội đại biểu toàn quốc lần thứ XIII của Đảng lần đầu tiên chính thức hóa thuậtngữ “quản trị quốc gia” và khẳng định “Đổi mới quản trị quốc gia theo hướng hiện đại, cạnh tranh hiệu quả” là một trong ba đột phá chiến lược. Để thực hiện được điều đó, cần tiến hành đổi mới quản trị trên mọi lĩnh vực. Trong đó, “quản trị truyền thông” là một trong những nội dung quan trọng nhằm hướng đến xây dựng hình ảnh và mối quan hệ tích cực, hữu ích giữa cơ quan hành chính nhà nước với người dân và các nhóm công chúng liên quan, thông qua đó huy động sự tham gia của các bên vào quá trình này. Bài viết phân tích thực trạng và đề xuất giải pháp tăng cường quản trị truyền thông của chính quyền địa phương trong bối cảnh cải cách hành chính nhà nước hiện nay.
Correlation of Oxidative Stress Parameters and Inflammatory Markers in Tunisian Coronary Artery Disease Patients
Authors:   Department of Clinical Biochemistry, CHU-Farhat Hached, Sousse, Tunisia, Dandana Azza , Addad Faouzi ,   Department of Cardiology, CHU-Fattouma Bourguiba Monastir, Tunisia, Gammoudi Imen , Ferchichi Salima , Chahed Hinda , Limam Hlima Ben , Miled Abdelhedi ,   Department of Clinical Biochemistry, CHU-Farhat Hached, Sousse, Tunisia
Published: September 2023

Introduction: Oxidative stress is now recognized as being the cause and the consequence of cardiovascular diseases. Objective: The role that oxidative stress parameters and inflammatory markers may play in diabetes and related cardiovascular disease (CVD) among Tunisian coronary diabetic patients. Patients and methods: We measured the erythrocyte glutathione peroxidase (GPX), the superoxide dismutase (SOD) activities and the plasmatic total antioxidant status (TAS) concentration by colorimetric methods, the hs-CRP by immunonephelometry assays. Results: TAS and GPX were significantly decreased among patients compared to the controls (1.14 ± 0.28 mmol/l vs 1.55 ± 0.35 mmol/l; 59.32 ± 10.72 U/gHb vs 149.19 ± 30.95 U/gHb). For the diabetic patients, TAS is correlated positively with hs-CRP (r=0.01, p<10-3). At the not diabetic subjects, TAS is correlated negatively with the hsCRP. Conclusion: Determination of antioxidative defense markers contributes to understanding the effect of stress oxidative on the development and the prevention of cardiovascular disease.
MafA is a Key Molecule in Glucose and Energy Balance in the Central Nervous System and Peripheral Organs
Authors:   Department of Medicine IV, Tokyo Women's Medical University, Japan, Tsuchiya Ken , Nitta Kosaku ,   Department of Medicine IV, Tokyo Women's Medical University, Japan, Tsuchiya Mariko , Fujita Mikiko , Takinishi Akira , Furukawa Maiko , Maeda Atsushi ,   Institute of Geriatrics, Tokyo Women's Medical University, Japan, Yasuda Kazuki ,   International Medical Center of Japan, Tokyo, Japan
Published: September 2023

MafA is a strong transactivator of insulin in pancreatic β cells. Elucidating the profile of MafA action in organs other than the pancreas is essential. We established an mRNA interference technique that modifies the level of target mRNAs in mice in vivo. After rapidly injecting MafA-siRNA, the resulting changes in the gene profile were analyzed using a microarray system. Significant suppression of the MafA mRNA levels was observed in the pancreas, liver, adipose tissue, and brain of siRNA-injected mice. As we reported previously, the down-regulation of insulin mRNA and adipocytokines was observed in the pancreas, and MafA siRNA caused alterations in the expressions of genes related to lipid metabolism and cell growth in the liver, and the attenuation of cell differentiation in cultured adipocytes. In addition to the effects on these organs, MafA expression was immunohistochemically detected in the brain in our preliminary data, and the expression level in siRNA-treated mice was significantly suppressed. The expressions of the affected genes were distinct, including growth hormone, vasopressin, hypocretin, and pro-melanin-concentrating hormone, were almost completely down-regulated (to ∼1/100). These results suggested that MafA is likely involved in the regulation of hormonal systems related to glucose metabolism, and MafA is likely positioned near the beginning of the cascade or may influence the expressions of the above-mentioned genes in coordination with other factors in brain tissue. Taken together, the findings in this study suggested that MafA functions as a transcription factor with distinct activities in each organ and is cross-linked in several organs
The Prevalence of Serum Immunoglobulin G Antibody to Chlamydia Trachomatis in Subfertile Women Presenting at the University of Port Harcourt Teaching Hospital, Nigeria
Authors:   Department of Obstetrics and Gynaecology, University of Port Harcourt Teaching Hospital, Port Harcourt, Nigeria, Jeremiah Israel , Okike Ola , Akani Chris
Published: September 2023

Objectives: This study was undertaken to assess the prevalence of IgG antibody to Chlamydia trachomatis in subfertile patients at the University of Port Harcourt Teaching Hospital and to determine associated factors between this and infertility. Study design: This case controlled study was conducted among 100 women presenting for infertility consultation at the University of Port Harcourt Teaching Hospital. One hundred women with normal intrauterine pregnancies attending the antenatal clinic were used as controls. A questionnaire was used to obtain information on their socio-demographic data, sexual and obstetric history administered to them. 2mls of venous blood was collected, labelled and sent to the laboratory. The presence of IgG antibody to Chlamydia trachomatis was determined. Hysterosalpingography was performed on all infertile women to assess tubal patency. Data management was with SPSS 15.0 for Windows® statistical software. Results: The mean age of the subjects was 30 ± 3.1 years, median parity 0.5 and average life time sexual partner 3.7 ± 2.8. All the participants in the study were married. 62% of subjects had tertiary education. The Chlamydia trachomatis IgG antibody prevalence in the subfertile population was 74% and 51% in the control group, P<0.001. Tubal occlusion occurred in 58 (78.4%) of cases positive for chlamydia antibody. Pelvic inflammatory disease and mucopurulent discharge were the most common presentating symptoms among Chlamydia antigen positive infertile women, P<0.001. There was an association between subfertility and the number of life time sexual partners. There was an association between subfertility and non usage of condoms. Conclusion: The prevalence IgG antibody to Chlamydia trachomatis was significantly higher in women with subfertility compared to women with proven fertility. There was a strong association between Chlamydia antibody positivity and tubal occlusion. In a resource-poor country such as Nigeria, enzyme immunosorbent assay for chlamydial IgG antibodies may be substituted for HSG for the detection of tubal occlusion.
Audit of Pediatric ENT Injuries
Authors:   University of Ilorin Teaching Hospital, Ilorin, Nigeria, Aremu (FWACS) S. K. , Alabi (FWACS) B. S. , Segun-Busari (FWACS) S. , Omotoso (MBBS) W.
Published: September 2023

Background: Ear, Nose and throat (ENT) injuries are relatively common in children. Sometimes they may result in disfigurement or dysfunction of the affected parts. This study was aimed at the pattern and mechanisms of ENT injuries encountered by children in Ilorin located in north central Nigeria. It is therefore our hope that the information will go a long way to assist other African countries as well in health care plans for children. Objectives: The study was aimed at determining the pattern and causes of ENT injuries in children in Ilorin. Methodology: This was a descriptive cross sectional, prospective study of all pediatrics patients aged 15 years and below who were managed between January 2005 and December 2009 (a period of 5 years) for ENT trauma in the accident & emergency unit, wards and clinics of University of Ilorin Teaching Hospital. Most of them were treated as out-patients; a few of them needed admission for some procedures. Patients with injuries to other areas than ENT were not included in this study. The data that were analyzed included the age, sex, presenting complaints, duration of symptoms prior to presentation, diagnoses, treatments and complications. Results: Two hundred and seventy-one children were studied, of which 168 (62.0%) were males and 103 (38.0%) were females. Most of the children, 97 (35.8%), were between age group of 6-10 years, 81 (29.9%) aged 5 years and below, while the rest were 11-15 years of age. Injuries due to foreign bodies in Ear, Nose and Throat accounted for 80 (29.5%) of the causes. Falls accounted for 60 (24.4%) of cases while Road Traffic Injuries (RTI), 42 (15.5%) of cases. Bleeding was the commonest presenting symptom. Most of the children, 97 (35.8%) presented within 1 hour of injury while the least, 45(16.6%), presented more than 8 hours after the injury. 132 (48.7%) had injuries in the Ear, 117 (43.2%) in the Nose and 22 (8.1%) in the Throat. Conclusion: ENT injuries in pediatrics are relatively common in our environment with injuries from FB insertion/ingestion being the commonest. This is closely followed by falls. Several disabilities and morbidity may result from the trauma like anosmia, facial palsy and permanently depressed nose. These have impact on psychology of the child. For these reason close monitoring of children by parents and care-givers cannot be overemphasized. Also these injuries are avoidable causes of death and disability in children.
Role of Genetic Changes in the Progression of Cardiovascular Diseases
Authors:   Department of Clinical Biochemistry, College of Medicine, Taibah University, Saudi Arabia, Sheweita S. A. , Baghdadi H. ,   Department of Clinical Biochemistry, College of Medicine, Taibah University, Saudi Arabia, Allam A. R. ,   Departments of Medicine, College of Medicine, Taibah University, Saudi Arabia
Published: September 2023

This review aims to investigate the role of genetic changes in the development of cardiovascular diseases [CVD]. Oxidation of Low density Lipoprotein (LDL) and mutations in LDLreceptors gene are a trigger for numerous of atherogenic events. Also, endothelial nitric oxide synthase (eNOS) plays an important role in vasodilatation of blood vessels through synthesis of nitric oxide.Three single base pair changes, 786T/C, 922A/G, and 1468T/A, have been identified in the promoter region of the eNOS gene and are associated with coronary spasm. Moreover, two distinct variable nucleotide tandem repeats (VNTRs) in introns 4 and 13 have been detected. The presence of a minimum of 38 CA repeats in intron 13 has been associated with an independent 2.2-fold increase in the risk of coronary artery disease [CAD]. Plasma glutathione peroxidase (GPx-3) maintains the vascular bioavailability of nitric oxide (NO), through depletion of reactive oxygen species. Mutation(s) or polymorphism(s) in the plasma GPx-3 gene promoter may predispose to a thrombotic disorder, and constitute a genetic risk factor for thrombotic cerebrovascular disease. Hyperhomocysteinemia is another independent risk factor for atherosclerosis and arterial thrombosis. Severe hyperhomocysteinemia could be caused by cystathionine-β-synthase enzyme deficiency but it could be due to homozygosity of a common 677C/T point mutation in the coding region of the methylenetetrahydrofolate reductase (MTHFR) gene as a 3-fold increase in risk of CAD is associated with the MTHFR 677TT genotype. A second common variant in MTHFR 1298A/C is associated with decreased enzyme activity in vitro and in vivo, especially when occurring simultaneously with the 677 C/T polymorphism. Elevated fibrinogen, an essential component of the coagulation system, has been most consistently associated with arterial thrombotic disorders. Several polymorphisms (148C/T, 455G/A, and -854G/A) have been identified in the genes encoding the 3 pairs of fibrinogen polypeptide chains. The -455G/A, and -854G/A substitutions are the most physiologically relevant mutations. In addition the -455A allele has been associated with the progression of atheroma, and also with a 2.5-fold increase in risk of multiple lacunar infarcts in a cohort of elderly patients with stroke. It is concluded that genetic changes in the previously mentioned genes could play a significant role in the initiation and progression of CVD. This review provides useful information for both physicians and medical students whom are interested in human genetics which is related to cardiovascular diseases
ROLES DE GÉNERO EN LA EXPRESIÓN CORPORAL Y MOTRIZ EN INFANTES DE 4 A 5 AÑOS
Authors:   UNIVERSIDAD DE GUAYAQUIL, Zeballos Chang Julia Lorena , Mantilla Pacheco Delfa Narciza , Montenegro Ramirez Rafael Fernando , Changuan Cedeño Clara Marina , Flores Figueroa Evelin Alexandra
Published: September 2023

El presente trabajo de investigación busca determinar la influencia de los roles de género en la expresión corporal y motriz en niños y niñas de 4 a 5 años a través de una investigación bibliográfica y de campo con enfoque cualitativo y cuantitativo. Para este estudio se consideró como objeto de estudio 54 estudiantes, 54 cuidadores, 2 docentes y directivo, a quienes se aplicó una técnica de dibujo, encuesta y entrevista respectivamente. Como resultado se conoció que el desarrollo de la expresión corporal y motriz se puede mejorar sin ningún contratiempo y sin distinción de género, sin embargo, los niños si muestran tales roles, especialmente asociados al deporte para chicos y chicas. Ante ello, se recomendó una guía de talleres parentales con el propósito de demostrar que no existen actividades sexualizadas, por tanto, hombres y mujeres son capaces de realizar deportes, juegos, usar colores, juguetes, bailes o movimientos porque los colores y juguetes no tienen género y son neutros
Construction and Standardisation of UGC-CARE List of Journals Awareness Test for Teachers and Research Scholars
Authors: Sharma Monika , Prakash Dr. Sumin
Published: September 2023

The present paper is an attempt to construct and standardized a UGC-CARE List of Journals Awareness Test for the Teachers and Research Scholars. The Final scale consisted of 44 items, distributed over 5 dimensions of UGC-CARE List of Journals as prescribed the UGC, New Delhi with effect from 14 June 2019, namely Background and Objectives of UGC-CARE, CARE protocols, CARE Universities and Committees, CARE Groups and Journal Analysis. The reliability of the Test was found to be 0.85 (Test-Retest Method) and 0.90 (Split Half Method). To determine the validity of the UGC-CARE List Awareness Test, the researcher showed the Test to a number of experts seeking judgement regarding the coverage of the constructs.
Serum Levels of Hcy, sST2 and CA-125 in CHF Patients and Their Correlation with Cardiac Function Classification
Authors: Ma Wuzhi , Zhang Peng , Hu Huiqiong
Published: September 2023

Background: The relationships between serum levels of homocysteine (Hcy), soluble stromelysin 2 (sST2), and tumor-associated cancer antigen 125 (CA-125) and heart failure requires further investigation. The aim of the present study was to evaluate the levels of Hcy, sST2 and CA-125 in patients with congestive heart failure and to correlate these with cardiac function, thereby providing a reference for the clinical diagnosis and treatment of heart failure. Methods: Seventy patients with chronic heart failure (CHF) diagnosed between August 2020 and July 2022 were classified into heart failure groups II (n = 25), III (n = 23) and IV (n = 22). Seventy individuals with normal physical examination results were selected as the healthy group. Serum Hcy, sST2 and CA-125 levels for all participants were evaluated and correlated with each other and with cardiac function classification. The diagnostic value of individual Hcy, sST2, CA-125 levels for CHF was evaluated, as well as a combination of these factors. Results: Hcy, sST2, and CA-125 levels were lower in the healthy group than in the heart failure group. Moreover, a progressive increase in Hcy, sST2, and CA-125 levels were observed in heart failure groups II, III, and IV. Individual Hcy, sST2 and CA-125 levels, as well as a combination of these factors, were significantly correlated with cardiac function classification (p < 0.05). Hcy, sST2 and CA-125 levels each showed diagnostic value for CHF, with the three combined having the best diagnostic value. Conclusions: Abnormally high levels of Hcy, sST2 and CA-125 occur in CHF patients and are positively correlated with cardiac function classification. Individual levels of these factors, and particularly a combination of the three, show good sensitivity and specificity for CHF diagnosis that could be widely used in clinical practice.
A Rare Case of an Adult Pregnant Patient with the Left Coronary Artery Originating from the Pulmonary Artery: Successful Management and Healthy Maternal-Fetal Outcome
Authors: Wang Huan , Liang Zhipan , Zhang Gen , Fang Haibing , Li Dianyuan
Published: September 2023

An anomalous left coronary artery originating from the pulmonary artery (ALCAPA) refers to the abnormal origin of the left coronary artery either from the main pulmonary artery, pulmonary artery sinus, or the left and right pulmonary arteries, with the main pulmonary artery or pulmonary artery sinus being the most common sites. If not diagnosed and treated promptly, this condition can result in death within the first year of life in 90% of patients. Asymptomatic children can survive into adulthood, but they are at a high risk of sudden death. In this article, we report a case of a 24-year-old pregnant woman who was diagnosed with ALCAPA during prenatal examination. The pregnancy was successfully maintained until 36 weeks, after which a cesarean section was performed. The patient was then admitted to the cardiac surgery department to improve cardiac function, and six weeks later, a successful left coronary artery transplantation was performed. The patient was discharged and followed up for three months, during which her condition remained stable.
Relación entre niveles de ansiedad y estrategias de afrontamiento en universitarios colombianos
Authors: Salamanca-Camargo Yenny , Sotomayor-Pinzón Yesica Andrea , Salas-Caína Sandra Marcela
Published: September 2023

Estudio no experimental de tipo correlacional cuyo objetivo fue identificar la relación entre niveles de ansiedad y estrategias de afrontamiento en 125 participantes, con un rango de edad entre 18 y 33 años y escolaridad entre primero y décimo semestre de psicología de una universidad colombiana; a partir de la Escala Zung para ansiedad y la Escala Estrategias de Coping. Los resultados indican manifestación de ansiedad moderada en el 41% de los participantes y severa en el 4%, siendo más frecuente la presencia de ansiedad en noveno semestre; en cuanto a estrategias de afrontamiento, se identifican como más utilizadas las relacionadas con solución de problemas (43%), reevaluación positiva (41%), búsqueda de apoyo social (34%) y evitación cognitiva (29%); mientras que la correlación entre variables es significativamente baja a excepción de la relación entre ansiedad moderada y la estrategia de afrontamiento reacción agresiva.
Brain Drain among Nigerian Doctors: Country’s Implications and Policy Responses
Authors:   Garden City Premier Business School, Port Harcourt-Nigeria, Tele Ikuru Mina , Opuala-Charles Silva
Published: September 2023

Over the past two decades, the migration of medical doctors has shown remarkable trends. In Nigeria, the medical profession stands out as one of the most mobile, highly skilled occupations and grapples with severe labor shortages. This study delves into two primary aspects. Firstly, it examines the main theoretical contributions and historical evolution of two phenomena: brain drain and medical brain drain. Secondly, it aims to raise inquiries, provide insights, pinpoint critical concerns, and propose potential solutions to curtail the emigration of medical doctors from Nigeria to developed nations. Secondary data source through desktop research was employed. Descriptive and explanatory research designs were used with mixed method research methodology involving qualitative and quantitative methods. Our results reveal that the attractive remuneration of doctors, a pleasant working environment, and adequate provisions for career advancement in the destination countries are among the pull factors for doctors' brain drain. In like manner, the surge in demand for healthcare services and improvements in medical technology in the receiving country act as driving forces behind the migration of medical doctors from developing nations, such as Nigeria. Keywords: Brain Drain; Migration; Poor Wages; Opportunities; Remuneration
Significados del suicidio en la (pos)pandemia:
Authors: Castillo Patton Andy Eric , Carretero García Carlota
Published: September 2023

Desde el 2020 se ha generado en España una emergencia discursiva en torno al suicidio que ha ocasionado una relevante movilización de la agenda mediático-política. Esto se advierte en el impulso de medidas como el teléfono de asistencia (024) por parte del Gobierno central. Sin embargo, lo interesante de esta decisión es su sustrato en un nuevo marco interpretativo de los significados del suicidio en la (pos)pandemia. Por tanto, a través de un análisis crítico del discurso, el presente texto observa una serie de fragmentos discursivos del discurso gubernamental y el testimonio de 4 periodistas especializados y 8 miembros de asociaciones de supervivientes en relación con estos cambios. Como principales resultados, se observan convergencias respecto a la identificación contextual del suicidio y la salud mental en la pandemia. Asimismo, supervivientes y periodistas destacan en problematizar la salud emocional como clave de un reclamo terapéutico de una prevención efectiva del suicidio.
Analisa Konseptual Tentang Karunia Mengajar
Authors: Sunarti Sunarti , Yanti Naomi Anggrawita
Published: September 2023

God equips teachers with the power and wisdom of the Holy Spirit, even so God still wants every teacher to have a mature readiness to become God’s tool in the world of education. This study aims to find out the problems that occur why Sunday school children at the Tegal Bethel Maranatha Chrurch in Central Tegal find it very difficult to concentrate when their teacher is explaining and the results of this study are finding the empowerment of the gift of teaching in the Sunday School teacher ministry according to Romans 12:6-8 in Tegal Center Bethel Maranatha Church is low due to several factors listed in this
Analisis Perbaikan Faktor Daya Untuk Efisiensi Pembebanan Pada RSUD I.A. MOEIS SAMARINDA
Authors: Rusdiansyah  , Cornelius Sarri  , Toyib
Published: September 2023

Perbaikan faktor daya sangat penting bagi industri dan  salah satunya adalah Rumah Sakit, Pada RSUD I.A. MOEIS kebanyakan beban bersifat induktif yang menyebabkan timbulnya daya reaktif, untuk itu diperlukan perbaikan faktor daya (cos φ) guna memperbaiki efisiensi pemakaian daya pada Rumah Sakit tersebut. Langkah untuk memperbaiki faktor  tersebut antara lain mengetahui beban total Rumah Sakit, nilai cos φ, rangkaian distribusi instalasi, dan menghiting konpensasi daya reaktif pada Rumah Sakit. Total beban puncak yang dipakai adalah 169.81 kVA, 70.67 kW dan 153,78 kVAR dengan cosphi 0,42, dan setelah dilakukan perbaikan faktor daya dengan pemasangan kapasitor Bank menggunakan metode pemasangan Global Conpensation dengan julah kapasitor yang digunakan Type CLMD43 - 3phase 10x20 kVAR dengan Power Factor Regulator RCV10 – 10 Step. Dan di dapatkan hasil yaitu 73,28 kVA, 70,67 kW dan 19,41 kVAR dengan nilai cosphi 0,96.
Special Medical Issues and Considerations for Women’s Football Players
Authors: Kim Lina
Published: September 2023

Football is a sports that the most attention and love from many countries and people regardless of gender around the world. Recently, FIFA (Fédération internationale de football association) has been actively helping female football players around the world with economic and technical support. In addition, FIFA has been making great efforts to revitalize the women's league. In this article, the medical issues that should be considered and examined by team doctors and medical teams and what problems should be particularly concerned in female football players will be divided into three categories to be gone through: sports injury, RED-s(relative energy deficiency in sports) and gender verification. First of all, it is known that the overall percentage of injury for female football players is lower than that of male players, however the rate of serious damage is higher in female football players due to the more frequent the knee anterior cruciate ligament injury and traumatic brain injury. It is important to know that RED-s starts with low energy availability as it progresses it can be a serious problem that deteriorates the health and performance of individual athletes. The issue of gender verification is needed to determine whether this player can participate in the women's competition, and it should be check whether this violates the spirit of fair play.
Thermography Applied to Damage Diagnosis over Monuments and Ancient Constructions
Authors:   Professor Responsible for Occupational Safety subjects, Occupational Risk Prevention Master’s Degree, Universitat Oberta de Catalunya, Rambla del Poblenou, Barcelona, Spain, Elizalde Ruben Rodriguez
Published: September 2023

Thermography is a technique based on the detection of radiation emitted by bodies, converting the information obtained in images into information on the temperature of their surface. The reduction in cost of these cameras and their incorporation into drones, as an additional element, opens the doors to a very useful new microtechnology, which we can take advantage of to auscultate monuments and their constituent materials.
Principle Operation of a Line Follower Robot
Authors:   Department of Computer Engineering Technology, School of Technology, Kano State Polytechnic, Kano, Nigeria, Baballe Muhammad Ahmad , Adamu Abdu Ibrahim ,   Department of Computer Science, Audu Bako College of Agriculture Danbatta, Kano, Nigeria, Ibrahim Amina ,   Department of Computer Science, School of Technology, Kano State Polytechnic, Nigeria, Bari Abdulkadir Shehu ,   Department of Computer Science, Audu Bako College of Agriculture Danbatta, Kano, Nigeria
Published: September 2023

A rudimentary autonomously guided robot called a "Line Follower Robot" (LFR) follows a line written on the ground to either find a white line on a dark surface or a dark line on a white surface. Working on the LFR is quite interesting. We will discover how to construct a black line follower robot in this study utilizing an Arduino Uno and a few readily available parts.
LA CONSOLIDACIÓN DE UNA PAZ ESTABLE Y DURADERA. RETOS PARA LA ESCUELA SEGÚN LAS RECOMENDACIONES REALIZADAS POR LA COMISIÓN DE LA VERDAD EN EL INFORME FINAL
Authors:   Universidad Pedagógica Nacional, Cruz León Erika Liliana
Published: September 2023

This article reveals the meaning of the adaptation and implementation of the Suggested Curriculum of English (CSI) in the District Schools of Bogotá. It was born from the need of a group of teachers to adapt and implement the CSI in a particular educational institution and from their common desire to improve their pedagogical practices and the results of the students in the Saber 11º Test. The documentary review seeks to provide a basis for the CSI and opens the door to a possible evaluation of it.
Differences in amino acid composition of carrot α-tubulin potentially confer the resistance to dinitroaniline herbicides
Authors: Melnyk O. G. , Blume R. Y. , Karpov P. A.
Published: September 2023

Aim. To reveal the features of amino acid composition of carrot α-tubulin isotypes that potentially determine natural tolerance to dinitroaniline herbicides. Methods. Literature and database search. Comparison of protein sequences and structures: multiple sequence alignment, phylogenetic profiling, protein and ligand structure modeling, etc. Results. Genomic and proteomic analysis of Daucus carota has revealed at least eight unique isotypes of α-tubulin that differ in amino acid sequences and gene loci. Remarkable differences in amino acid composition of the dinitroanilinebinding-like (DBL) region of analyzed α-tubulin have been revealed, which may be the reason of its natural resistance to these compounds. Сonclusions. Differences in amino acids at positions of canonical mutations – Cys4 (TBA1, 2, 3, 6, 7 and 8), Thr53 (TBA6), Ile202 (TBA1 and 7) and Met202 (TBA5), as well as previously undescribed non-canonical substitutions – Ile4 (TBA4 and 5), Cys52 (TBA6), Ser201 (TBA1, 2, 3 and 8) and Val194 (TBA4 and 5), were noted as potentially associated with natural tolerance of the carrot to dinitroaniline herbicides.
Analysis of Atg proteins involved in the formation of the Atg1 complex, their interaction with the Atg8 protein during autophagosome maturation
Authors: Bulgakov E. V. , Rayevsky O. V.
Published: September 2023

Aim. Relying on the data from numerous researches on the representatives of ATG proteins from H.sapiens and S.cerevisiae organisms, we decided to explore the difference between ATG proteins from plant organism. Subsequent stages comprised the determination of in silico phosphorylation effects on the native structure of the protein model and the possible influences on the stability of the three-dimensional complex by the molecular dynamics method. Methods. Methodologically, one can highlight the process of models elaboration on known sequences in AlphaFold 2.0 program and subsequent mechanistic review of molecular mobility of the obtained conformational models through the molecular dynamics in Gromacs 4.5 program and Charmm36 force field. Results. As a result of the model development and exploring the process of ATG-protein complexation, the geometrical specificities of the structures under investigation revealed the binding sites on the surface of the Atg1 complex components. We also suggested some areas for the intermolecular interactions based on the already published data on experimentl mutagenesis. Additively, we performed an analysis of the molecular dynamics simulations in the case of phosphorylation and its effect on the conformational mobility of these objects. Conclusions. Applying the computer simulation modelling methods we created the Atg1 complex elements and then analyzed these four proteins participating in the process.
Surnames in population genetics: pros and cons
Authors: Atramentova L. O.
Published: September 2023

The article presents arguments regarding the perspective of studying the population using surnames as a tool of population genetic research. The model of a virtual polyallelic locus linked to the Y chromosome in peoples with patrilineal inheritance and linked to mtDNA in peoples with matrilineal inheritance is presented, which allows analyzing the distribution of surnames by means of population genetics. It is proved that the change of surnames at the time of marriage, false paternity and spelling errors do not affect the overall result of the calculations. Attention is drawn to the selective neutrality of surnames in relation to the natural environment and selectivity to the social environment. Examples of the advantages of surnames as population markers are given: quick obtaining of results, low financial cost of works compared to effectiveness, absence of statistical and ethical problems. The expediency of using surnames for the study of Ukrainian populations is proven by their compliance with the conditions put forward for markers. In conditions that make it impossible to collect actual material in populations and laboratory analysis of biological samples, working with lists of surnames is best suited for undergraduates and graduate students conducting research in anthropogenetics.
The role of the HLA-complex genes in genesis of human idiopathic recurrent pregnancy loss
Authors: Terpyliak O. I. , Zastavna D. V. , Sosnina K. O. , Filenko O. L.
Published: September 2023

Aim.To study the immunogenetic prerequisites of idiopathic recurrent spontaneous pregnancy losses in humans of allo- and autoimmune genesis. Methods. PCR-SSP (polymerase chain reaction with sequence-specific primers). Results. A comprehensive analysis of the distribution and frequency of allelic variants of the HLA-DRB1, HLA-DQA1, HLA-DQB1 genes testifies to an increased risk of recurrent pregnancy losses with a total homology of 50 % or more in couples and presence of the DQ2.5 genotype in a woman. The OR indicates that the risk of idiopathic recurrent spontaneous pregnancy loss increases 2.68 times when the homology of the couples is 50 % or more for two loci (HLA-DRB1, HLA-DQA1) and 12.8 times when the homology is 50 % or more for by three loci (HLA-DRB1, HLA-DQA1, HLA-DQB1), and if the DQ2.5 genotype is present in women, this risk increases 4 times. Conclusions. HLA genotyping of married couples with a history of spontaneous pregnancy loss is important for preconceptional prevention of recurrent pregnancy losses.
The effect of free proline accumulation on the content of photosynthetic pigments in transgenic wheat plants
Authors: Dubrovna O. V. , Priadkina G. O.
Published: September 2023

Aim. To analyze the effect of L-proline accumulation on chlorophyll content in transgenic wheat plants with a double-stranded RNA suppressor of the proline dehydrogenase gene under physiological and stress conditions. Methods. Agrobacterium-mediated transformation in planta; biochemical determination of free proline content; spectrophotometric determination of photosynthetic pigments content; of mathematical statistics. Results. It was shown that the content of free proline in the leaves of transgenic plants under physiological conditions was 1.7-1.9 times higher compared to the original genotype. Under conditions of drought, the content of this aminoacid increased in non-transformed plants of the original genotypes by 2.9-3.1 times, and in transgenic plants – by 4.5-4.9 times. The amount of chlorophyll in the flag leaves of plants of the original genotypes and their transgenic lines under physiological conditions did not differ significantly, while under drought conditions in the first of them it was 1.1-1.2 times less than in the second. Drought reduced the total chlorophyll content in plants of the original genotype to 85-90 %, compared to physiological conditions, while no significant changes were found in transgenic plants. Conclusions. It was established that under conditions of soil drought, the increase in proline content in genetically modified wheat plants compared to non-transgenic ones is accompanied by an increase in the amount of total chlorophyll (by 10-15 %), which indicates a better efficiency of their pigment apparatus under stressful conditions.
Telepsychiatry and mental health equity in correctional facilities: Legal opportunities and challenges
Authors: Patrinos Dimitri
Published: September 2023

Lack of access to mental health care in Canadian correctional facilities is a serious and longstanding issue. Telepsychiatry, which entails the usage of information and communications technologies to provide remote mental health care to patients, has been demonstrated to be an effective model of mental health care provision in correctional facilities. The right to health care, including mental health care, of inmates is recognized in both international and domestic law. However, mental health conditions remain suboptimal in Canadian correctional facilities and are far below the standards which exist in the general community, leading to significant mental health disparities for inmates. Telepsychiatry can be viewed as a vector for increasing mental health equity in the correctional system and provides a promising opportunity for correctional facilities to meet their legal obligations to provide inmates with health care, including mental health care. This article explores the legal frameworks governing the provision of mental health care services in Canadian correctional facilities and highlights the role telepsychiatry can play in the fulfillment of these legal frameworks. It also explores the legal challenges facing the implementation of telepsychiatry in correctional facilities. Ultimately, despite these challenges, it argues that telepsychiatry should be more widely implemented in correctional facilities to ensure mental health equity for inmates.