bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Different Bases of Vegetable and Carrageenan Concentrations on The Quality of The Mix Vegetable Leather of Lettuce and Mustars Greens
Authors: Sabila Cut Putri Hadiati , Mujdalipah Siti , Fishi Ana Nadiya Afinatul
Published: August 2024

The benefits of each vegetable are different, one vegetable cannot be substituted for another. Vegetable processing in Indonesia is still very limited to sautéed, boiled, steamed or eaten directly, meaning that people's interest in vegetable consumption is still relatively low. However, increasing public awareness of the use of vegetables encourages variations in vegetable processing. One of the processing that can be applied to vegetables is manufacturing mix vegetable leather. Vegetable leather is a processed product derived from crushed and dried vegetables. The diverse benefits of each vegetable encourage its creationmix vegetable leather orvegetable leather which uses more than 1 vegetable as the basic ingredient. Mustard greens and lettuce are vegetables with high production in Indonesia. Apart from that, the crude fiber from mustard greens is 51.07%, while lettuce contains 50.7% crude fiber. The purpose of this study is to obtain the effect of vegetable basis and carrageenan concentration variance on mix vegetable leather of lettuce and mustard greens. The increase of people awareness of vegetable utilization drives to variate the vegetable processing. Each vegetable has its own unique benefits thus they could not be easily subtituted and mixed. This study used RAL with two factors, those are variety of vegetable basis between lettuce and mustard greens (30,50,100) and carrageenan consentration (1% and 1,5%). The chemical respond in this study covers moisture content, ash content, and crude fiber, while the organoleptic respond covers color, aroma, flavor, and texture. The best treatment is found on A1B1, that has 30 g for vegetable basis and 1% of carrageenan consentration with 13,31 % moisture content, 12,29% ash content, 8,24% crude fiber, 3,7 score in color and 2,05 color quality; aroma 3.23 and aroma quality 2.80; taste 3.40 and taste quality 3.06; and texture 3.46 and texture quality 3.73.
The Happy Spiritual Intervention for Overcoming Intolerance of Uncertainty among Families of Patients with Mental Disorders
Authors: Dwidiyanti Meidiana , Sawitri Dian Ratna , Munif Badrul , Fitri Anindiyani , Wijayanti Diyan Yuli
Published: August 2024

Families of patients with mental disorders frequently experience intolerance of uncertainty due to prolonged treatment, high caregiving burdens, and unpredictable patient behaviors. This study was conducted to investigate the effects of Happy Spiritual Intervention on the intolerance to uncertainty among families of patients with mental disorders. A pre-post quasi-experimental study with a control group was carried out among families of patients undergoing treatment at Dr. Amino Gondohutomo Psychiatric Hospital in Semarang. Simple random sampling was applied to recruit a total of 50 respondents who were aged 18 years or older and had been cohabiting with the patients for more than five months. The intervention group received six 45-minute therapy sessions, while the control group received standard care. This study utilized the Intolerance of Uncertainty Scale as research instrument. Data were collected using Google Forms, and subsequent analysis using a t-test was performed. The results revealed a significant difference in intolerance of uncertainty among families of patients with mental disorders after the intervention in both the intervention and control groups, with an effect size of 3.026 and a p-value of 0.000. This suggests that Happy Spiritual intervention effectively reduces the intolerance of uncertainty among families of patients with mental disorders.
Overcrowding and Stress Levels among Female Prisoners: A Cross-Sectional Study
Authors: Rabbani Hasna , Hidayati Nur Oktavia
Published: August 2024

Overcrowding is when the number of people in a space exceeds its specified capacity. This phenomenon often occurs in prisons and has been recognized as a significant contributor to psychological problems, especially stress among prisoners. This study addresses this gap by narrowing our focus to female prisoners, who exhibit greater physical and psychological vulnerabilities than male prisoners. This study investigates the relationship between overcrowding and stress levels in prisoners. This study used a correlational design with a sample of 82 female prisoners selected using a simple random sampling technique. The Overcrowding Scale and the Perceived Stress Scale-10 were the standardized instruments used in this study. Data were analyzed using Rank Spearman. The analysis revealed a positive relationship between overcrowding and stress levels with p = 0.000 and r = 0.415. Therefore, nurses can provide education to minimize the prisoners’ stress levels, and prison officers can improve prisoner fulfillment of psycho-socio-spiritual needs. Future comparative studies can be conducted across various prison facilities to identify variations in stress levels, assess the effectiveness of interventions, and explore sociocultural influences on the well-being of prisoners.
Estimasi Logam Berat Kadmium (Cd) dan Tembaga (Cu) Perairan Muara Kali Ijo, Pantai Ayah, Kebumen
Authors: Ibrahim Wahyu Satriarman , Hendrayana Hendrayana , Hidayati Nuning Vita , Kurniawati Any , Prihatiningsih Isnaini , Raharjo Purwo , Mulyani Sri
Published: August 2024

Keberadaan Muara Kali Ijo, Kebumen dapat dikatakan sebagai penampungan terakhir yang berasal dari industri, pertanian, perikanan, dan rumah tangga karena perairan pesisir merupakan tempat bermuaranya sungai dan akan menjadi tempat berkumpulnya zat-zat pencemar serta sumber kontaminan berbahaya, termasuk kontaminasi oleh logam berat jenis kadmium (Cd) dan tembaga (Cu) yang diduga dapat menimbulkan pencemaran perairan. Penelitian ini bertujuan untuk mengetahui kandungan logam berat Cd dan Cu perairan serta tingkat pencemaran berdasarkan Nemerow Pollution Index (PN). Metode penelitian yang digunakan adalah metode survei, dengan teknik pengambilan sampel menggunakan purposive sampling. Lokasi penelitian terdiri dari 4 stasiun, berada di area outlet sungai, mangrove kawasan ekosistem esensial (KEE), dan muara sungai. Hasil analisis data secara deskriptif menunjukkan bahwa kandungan Cd perairan memiliki nilai rata-rata 0,014 mg/L, sedangkan kandungan Cu memiliki nilai rata-rata 0,013 mg/L. Kandungan logam berat Cd dan Cu perairan telah melebihi baku mutu menurut PP No. 21 Tahun 2021 tentang baku mutu biota laut, sehingga sudah tidak baik bagi organisme akuatik. Tingkat pencemaran perairan di Muara Kali Ijo sudah terkontaminasi berat berdasarkan Nemerow Pollution Index (PN).
Kata Kunci: Logam Berat, Kadmium (Cd), Tembaga (Cu), Nemerow Pollution Index (PN), Muara Kali Ijo
Global, regional, and national burden of early-onset gastric cancer
Authors: Tan Nuopei , Wu Hongliang , Cao Maomao , Yang Fan , Yan Xinxin , He Siyi , Cao Mengdi , Zhang Shaoli , Teng Yi , Li Qianru , Wang Jiachen , Xia Changfa , Chen Wanqing
Published: August 2024

Objective: The burden of gastric cancer (GC) across different age groups needs updating. We determined the GC global, regional, and national burden profiles and changes in incidence for 3 sequential 5-year intervals from 2003 to 2017. Methods: The latest incidence and mortality estimates of GC from 185 countries and regions were extracted from the GLOBOCAN 2022 database. The 5-year interval age-standardised incidence rates (ASIRs) were evaluated using cancer registry data from volumes X–XII of the Cancer Incidence in Five Continents (CI5). Correlation analysis was used to evaluate the relationship between ASIR or the age-standardised mortality rate (ASMR) and the Human Development Index (HDI). Results: There was an estimated global 968,000 new GC cases and 660,000 deaths in 2022, with male predominance. GC ASIRs and ASMRs were 9.2 and 6.1 per 100,000 persons, respectively. East Asia had the highest burden, with 53.8% of cases and 48.2% of deaths among all geographic regions. There was a significant correlation between ASIR and HDI. Over three 5-year intervals from 2003 to 2017, the incidence of GC notably decreased in most countries but peaked at 2008–2012 in New Zealand, Turkey, and South Africa. Several countries in Europe, Oceania, and America suggest an increasingly concerning trend among younger individuals, especially females. Conclusions: GC is a significant health issue, especially among males and in geographic regions with an HDI, such as eastern Asia. While the incidence of GC is decreasing in many countries due to prevention efforts and improved treatments, a rising trend persists among younger individuals. Comprehensive prevention strategies tailored to different age patterns are clearly needed.
Masculinidad y políticas públicas: la organización de una agenda en México
Authors: Ramírez Rodríguez Juan Carlos , Gutiérrez de la Torre Norma Celina
Published: August 2024

The main purpose of this communication is to identify, to describe the process of building a public policy agenda that involves men in the construction of equality with women, and to recognize the perception of those who participated in it. It conceived the process as an organization with its own dynamics. A descriptive research about ethnographic approach involved recovery of documentary information of the process, interviews with participants in the construction of the agenda and a workshop. Results are presented in a timeline involved papers to prepare work meetings; profiles of potential participants were identified, the work to be developed was outlined and the respective call for in-person and virtual meetings was issued. Participants in the work meetings discussed contents of the agenda and political impact, the requirements to continue the process and the formation of specialized working groups. Elements such as uncertainty, the breaking of agreements and their fixed, the (mis)knowledge of what public policy among others, intervened in the process. As a conclusion, the lessons that emerge from this process are noted.
Illegal waste dumping in the Slovak Republic
Authors: Škrobák Ján
Published: August 2024

The paper aims to outline the legal aspects of illegal waste dumping in the Slovak Republic. It presents some factual information on the issue and the legal regulations governing waste management, landfill operations, and illegal waste disposal. The analysis includes suggestions for improving legal regulations, specifically focusing on identifying those responsible for illegal waste disposal and determining who is obligated to remove the waste legally. It also discusses the administrative and criminal penalties for illegal waste dumping.
Locus standi in administrative proceedings concerning environment protection, in the case law of the CJEU and the ECtHR
Authors: Ujhelyi-Gyurán Ildikó , Lele Zsófia , Pártay-Czap Sarolta
Published: August 2024

Effective legal protection against the unlawfulness of administrative acts is essentially achieved if the aggrieved party has some form of legal remedy to enforce his/her rights. This remedy may be at the stage of the administrative procedure, however, in some cases it may achieve its real purpose only through judicial means. The right to a fair hearing is closely linked to the right to remedy, which means the possibility of simultaneously appealing to another body or to a higher forum within the same organization regarding decisions on the merits. An essential element of all remedies is the possibility of remedy, i.e. the remedy conceptually and substantively includes the possibility of reviewing of the violation of law. The aim of the person affected is nothing other than to remedy his or her disadvantage. But who can be affected?
Advancing Circular Economy: Czech perspective
Authors: Vodička Jiří
Published: August 2024

This article provides a comprehensive overview of the transition to a circular economy, focusing on the European Union’s (EU) efforts and the Czech Republic’s stance and actions. It elaborates on the urgent need to shift from a linear economy, which burdens Earth’s resources and leads to substantial waste, to a more sustainable circular economy by 2050. The circular economy paradigm is seen as a fundamental shift in managing waste and resource use towards maintaining the value of products and materials for as long as possible and minimising waste generation. The article outlines the EU’s initiatives, policies, and legislation to foster this transition, emphasising the critical role of member states in implementing specific measures. Several EU policies, like the Green Deal and the New Circular Economy Action Plan, aim to transform the economy from linear to circular, covering various waste streams and sectors. Particular attention is given to the Czech Republic’s position and efforts. It delves into Czech waste legislation, policies related to the circular economy, and the nation’s strategic documents like the State Environmental Policy 2030 and the Strategic Framework of the Circular Economy of the Czech Republic 2040; these aim to improve waste management, enhance material supply security, boost business competitiveness, and reduce fossil fuel consumption. The article also discusses the challenges and public opinion in the Czech Republic regarding environmental protection and the circular economy. Despite progress, factors such as inadequate use of economic instruments and public reluctance to pay more for sustainable products hinder a faster transition. Furthermore, the article reviews specific legal instruments, economic tools, and sectoral legislative acts contributing to circularity in the Czech Republic. In conclusion, while the Czech Republic and the EU have made strides towards a circular economy, the journey is ongoing. The transition promises long-term benefits like self-sufficiency, reduced greenhouse gases, and new job opportunities. The EU’s role is crucial in this transition, as it sets legislative and policy frameworks that guide member states towards circularity. This article reflects the complexities and multifaceted nature of transitioning to a circular economy, highlighting the need for continued efforts, policy alignment, and societal support.
Legal provisions for the facilitation of the transition to a circular economy in the Polish legal system
Authors: Zębek Elżbieta
Published: August 2024

The transition to a circular economy (CE) is a priority objective for European Union (EU) Member States. Specifically, this goal is stated in the 8th Environmental Action Programme (which outlines a programme until 2030), the European Green Deal, European Commission communications, and the Waste Framework Directive 2008/98/EC as amended by Directive 2018/851. As a member of the EU, Poland is obliged to align its waste management practices with the CE; this work is reflected in legislative changes related to waste, packaging, and the municipal maintenance of cleanliness and order. This article presents the legal status of the transition to a CE in Poland, including the established legal instruments. The Polish legal system has developed measures to protect the environment, life, and human health by preventing and reducing waste and improving the efficiency of raw material use. Waste management is consistent with the waste hierarchy, with a focus on maximising recovery (material and organic recycling, energy recovery), an extended producer responsibility system, and strict requirements for recovery and recycling rates, with a particular focus on plastic packaging. In Poland, the CE Roadmap—which includes a legislative toolkit on sustainable industrial production, sustainable consumption, bioeconomy, new business models, and CE implementation and monitoring – has been developed for the transformation toward a CE. Poland’s priorities in this regard include: (1) innovation, strengthening cooperation between industry and the scientific sector, resulting in the implementation of innovative solutions in the economy; (2) creating a European market for secondary raw materials, where their movement would be easier; (3) ensuring the high quality of secondary raw materials that results from sustainable production and consumption; and (4) developing the service sector.
Harnessing regulation for circular economy advancement: Identifying breakthrough areas in the European Union and Hungary
Authors: Mélypataki Gábor , Musinszki Zoltán , Hódiné Hernádi Bettina , Bereczk Ádám
Published: August 2024

The prevailing linear economic model, characterized by resource extraction, production, consumption, and disposal, is unsustainable and poses significant environmental and social challenges. The circular economy (CE) has emerged as a transformative paradigm emphasizing resource efficiency, waste minimization, and closed-loop production systems. This paper provides a comprehensive overview of the CE concept, its potential benefits and challenges, and the regulatory frameworks enacted by the European Union (EU) and Hungary to facilitate the transition towards a circular economy. In order to facilitate this, the authors also propose specific regulatory steps based on a systematic concept.
Regulation of unlawful waste deposition in the Republic of Slovenia
Authors: Juhart Miha
Published: August 2024

The Republic of Slovenia transposed its obligations outlined in Directive 2008/98 to the Environmental Protection Act through a legal order. Its first unlawful waste disposal regime was implemented in 2008. The responsibility for unlawful waste disposal  is primarily placed on  the polluter, while  the subsidiary  responsibility  lies with  the  real estate owner. The owner of the real estate on which the waste is unlawfully disposed must arrange for proper disposal of the waste at his own expense if ordered by the inspection authority. The subsidiary responsibility of the real estate owner implies strong interference with the right to the property. To date, the Constitutional Court has not yet assessed the compatibility of this measure with the Constitution, as it has taken the view that it will not carry out an abstract assessment but will only make a decision through a constitutional appeal procedure. Despite several concerns, the regulations were maintained in the new Environmental Protection Act of 2022. In addition to the unlawful disposal of  waste,  this  Act  also  regulates  the  legal  consequences  of  littering;  further,  the  Act  imposes  relatively  high administrative  fines,  including  on any landowner who  fails  to exercise his  secondary  responsibility. Notably, the unlawful disposal of waste is defined as a criminal offence that burdens and destroys the environment. The legal framework, in my opinion, fully meets the requirements of Article 36 of Directive 2008/98/EC.
Psychosocial Syndemic Burden, Sexual Behaviors, and Engagement in HIV Prevention Care Among Sexual and Gender Minority Youths: United States, 2022
Authors: Valente Pablo K. , Neupane Raghavee , Eaton Lisa , Watson Ryan J.
Published: August 2024

Objectives. To examine linear and nonlinear associations between psychosocial syndemic factors and HIV risk and engagement in HIV prevention care among sexual and gender minority (SGM) youths.

Methods. Between February and October 2022, we recruited 17 578 SGM youths aged 13 to 18 years in the United States for an online survey. We examined the relationship of syndemics (i.e., binge drinking, drug use, sexual victimization, and anti–lesbian, gay, bisexual, and transgender discrimination) with sexual behaviors (i.e., sexual initiation, condomless anal or vaginal sex, and number of sexual partners) and HIV prevention care (i.e., HIV testing, preexposure prophylaxis awareness and utilization) using regression.

Results. Psychosocial syndemic burden (number of syndemic factors reported) was linearly and cubically associated with engagement in sexual behaviors. Psychosocial syndemic burden was linearly associated with higher HIV testing and preexposure prophylaxis awareness and cubically associated with higher preexposure prophylaxis utilization.

Conclusions. Our findings are evidence of synergism across psychosocial syndemic factors regarding HIV risk and engagement in HIV prevention care among SGM youths in the United States.

Public Health Implications. Multicomponent interventions may help reduce HIV risk and promote access to HIV prevention services among SGM individuals aged 13 to 18 years. ( Am J Public Health. 2024;114(9):892–902. https://doi.org/10.2105/AJPH.2024.307753 )
A broadscale assessment of Sentinel-2 imagery and the Google Earth Engine for the nationwide mapping of chlorophyll a
Authors: Johansen Richard , Reif Molly , Saltus Christina , Pokrzywinski Kaytee
Published: August 2024

Harmful algal blooms degrade water quality and can result in adverse health impacts to humans and wildlife. Monitoring these at scale is difficult due to the lack of coincident data. Additionally, traditional field collection methods are labor- and cost-prohibitive, resulting in disparate data collection not capable of capturing the physical and biological variations within waterbodies or regions. This research attempts to alleviate this by leveraging large, public, water quality databases coupled with open-access Google Earth Engine-derived Sentinel-2 imagery to evaluate the practical usability of four common chlorophyll a algorithms as a proxy for detecting and mapping algal blooms nationwide. Chlorophyll a data were aggregated from spatially diverse sites across the continental US between 2019 and 2022. The 2BDA and the NDCI algorithms were the most viable for broadscale mapping of chlorophyll a, which performed moderately well, encompassing highly diverse spatial, temporal, and physical conditions. The most compatible field data acquisition method was the chlorophyll a, water, trichromatic method, uncorrected with R2 values of 0.63, 0.62, and 0.41 and RMSE values of 15.89, 16.2, and 23.30 for 2BDA, NDCI, and MCI, respectively. These indicate the feasibility of utilizing band ratio algorithms for broadscale detection and mapping of chlorophyll a as a proxy for HABs, which is valuable when coincident data are unavailable or limited.
Interference with GINS2 inhibits ovarian cancer cell cycle entry by degrading CyclinA2 through ubiquitination
Authors: Lin Bei , Zhao Yue , Lin Bei , Rehman Aziz
Published: August 2024

The abnormal regulation of the cell cycle in tumor cells is linked to their proliferation, drug resistance, and recurrence. However, the mechanisms behind cell cycle regulation still need to be revealed for malignant tumor treatment. In this study, we conducted a bioinformatics analysis on the ovarian tissue mRNA microarray datasets from the GEO database. It revealed the involvement of GINS complex subunit 2 (GINS2), one of the main components of CMG helicase, not only in DNA replication, but also in cell cycle regulation. Experimental verification showed that GINS2 was regulated by cell cycle transcription factor E2F1 and could, in turn, improve the expression of Cyclin A2, promoting the transformation of cell cycle G1/S phase and the proportion of S phase. Surprisingly, GINS2 affected Cyclin A2 expression via ubiquitin degradation of MCM7 independent of the P53 and P27-associated extranuclear pathways. These findings emphasize GINS2's significance in the functional regulation of CMG helicase. The study concludes that GINS2 is a key player in the direct feedback up-regulation of the cell cycle through affecting Cyclin A2 expression, providing new insights into cell cycle regulation mechanisms.
Effect of aggregate type based on dynamic shear rheometer on aggregate asphalt-interface interaction
Authors: Gong Xiangbing , Ma Meiling , Qian Guoping , Yu Huanan , Cai Jun
Published: August 2024

In order to study the effects of different lithologic aggregates on the interaction between aggregate-asphalt micro interface, the researchers conducted microscopic tests to analyze the aggregates' chemical composition, micromorphology, and micro roughness. Metal plates were also used as a control group for comparison. In addition, the researchers used a contact angle measuring instrument to investigate the coating effect of asphalt and aggregate at high and medium temperatures. The mechanical properties of the aggregate-asphalt-aggregate system under various adhesion conditions were comprehensively explored through dynamic shear rheology tests and direct tensile tests of the aggregate-asphalt interlayer. The results showed that the microscopic coating effect of asphalt and aggregate and the micro-roughness of the aggregate had a nuanced relationship. The basalt-asphalt interface was found to have good high-temperature properties, while the limestone-asphalt interface demonstrated optimal medium-temperature properties. Lastly, the granite-asphalt interface was found to have the best low-temperature crack resistance.
Which adult diet is better? Comparative analyses of carbohydrate and protein rich diets on growth and reproduction of Chrysoperla zastrowi sillemi (Esben-Peterson)
Authors: Satapathy Satya Narayan , Mandal S M A , Adhikary Rahul , Patra Chakradhar , Lenka Biswajit , Tripathy Barsha , Badu Meenakshi , Acharya Subham , Mohapatra Subrat Kumar
Published: August 2024

Background:A comparative study was conducted in the Bio-control laboratory, Department of Entomology, College of Agriculture, Odisha University of Agriculture and Technology, Odisha, India during 2020-21 and 2021-22 to determine the effects of different combination of carbohydrate and protein source artificial diets on larval duration, egg hatchability and sex ratio of green lacewing, Chrysoperla zastrowi sillemi (Esben-Peterson).Six adult diets i.e.,Diet 1 (Water,Honey and Protinex), Diet 2 (Water, Honey and Castor pollen), Diet 3 (Water, Honey, Protinex and Castor pollen), Diet 4 (Water, Molasses and Protinex), Diet 5 (Water, Molasses and Castor pollen) and Diet 6 (Water, Molasses, Protinex and Castor pollen) were evaluated along with check (Diet 7 =Water and Honey).
Results: Maximum developmental period of first, second and third instar larvae i.e., 3.40 days, 3.10 days and 3.16 days were recorded in Diet 1, respectively followed by Diet 3 i.e., 3.37 days, 3.07 days and 3.12 days, respectively.Highest egg hatching percentage of 98.78% was recorded in Diet 1 with 6.90% increase in egg hatching percentage over check (Diet 7)followedby 97.89% and 97.56% in Diet 3 and Diet 2 with 5.94% and 5.59% increase in egg hatching percentage over control, respectively.Most desirable female-biased sex ratio (male: female) was observed in Diet 1 i.e.,1:1.86 followed by Diet 3i.e.,1:1.79 and Diet 2i.e., 1:1.74.
Conclusions: It is clear that feeding adults a fresh food would improve the survivability and predatory efficiency of Chrysoperla zastrowi sillemi larvae. The development and growth of this predator can be enhanced with a semi-defined diet. In comparison to natural foods like nectars, diets high in carbohydrates and protein are more suited to and convenient for adults when raising green lacewings in large numbers.
Genotoxicity and cytotoxicity evaluation of brown algae (Cystoseira indica) extract in human gingival fibroblast (HGF) and lung cancer cell lines (A549)
Authors: Habibi Emran , Sheikhzadeh Sahar , Arabnozari Hesamoddin , Shokrzadeh Mohammad , Sharifianjazi Fariborz , Sarker Satyajit D. , Tavamaishvili Ketevan , Nahar Lutfun
Published: August 2024

Cancer, particularly lung cancer, remains a leading cause of mortality worldwide, highlighting the need for new remedies. The brown algae species, C. indica, has gained attention for its rich phytochemical composition and pharmacological potential. This study evaluated the genotoxic and cytotoxic effects of C. indica extract on human gingival fibroblast (HGF) and lung cancer (A549) cell lines. Algae materials were extracted using sequential maceration, and fucoxanthin content was determined via High-Performance Liquid Chromatography (HPLC). Cytotoxic and genotoxic effects were assessed using MTT and comet assays, with statistical analyses performed using GraphPad Prism software. The algal sample contained 3.077 μg of fucoxanthin per 1g in n-hexane-acetone extract and 4.32 μg of fucoxanthin per 1g in ethanolic extract. n-Hexane-acetone and cold water extracts at 5000 µg/mL concentration exhibited the highest antioxidant activities in the DPPH assay with IC50 values of 306.15 ± 18.46 μg/mL and 8370 ± 2460 μg/mL, respectively. n-Hexane-acetone extract induced 50.66% apoptosis and hot water extract caused 54.97% apoptosis at 100 µg/mL. C. indica offers unique metabolites with potential pharmaceutical applications, especially as cytotoxic agents against cancer. The n-hexane-acetone extract, rich in flavonoids and phenolics, showed significant antioxidant and anticancer effects, inducing notable apoptosis in A549 cancer cells, suggesting further investigation for anticancer use.
Effect of the COVID-19 Pandemic and Official Media Report on China Stock Market
Authors: Wang Jiao , Wang Xiaomei
Published: August 2024

The specific impact of the COVID-19 pandemic on China stock market is currently unclear. The data of COVID-19 pandemic and 7048 official media reports are obtained via crawler technology from 2020 to 2021. This study compares and analyzes the impact of the two outbreaks on the stock market, focusing on official media reports and the pandemic prevention and control. The findings show that the two outbreaks of COVID-19 have different impacts on China stock market. The negative reports of official media have a negative impact on stock market, the positive reports have a short-term positive impact on stock market.
Childhood predictors of inner peace: A cross-national analysis of the Global Flourishing Study
Authors: Lomas Tim , Padgett R. Noah , Ritchie-Dunham James L. , Lee Matthew T. , Pawelski James O. , Shiba Koichiro , Johnson Byron R. , VanderWeele Tyler J.
Published: August 2024

Great efforts have been expended studying how people’s childhood affects outcomes later in life. Although attention has mostly focused on ‘negative’ outcomes, such as mental illness, paradigms like positive psychology have encouraged interest in desirable phenomena too. Yet amidst this ‘positive turn’ some desiderata have still received scant engagement, including inner peace. This lacuna perhaps reflects the Western-centric nature of academia, with low arousal positive emotions being relatively undervalued in the West. But aligning with broader efforts to redress this Western-centricity is an emergent literature on this topic. This report adds to this by presenting the most ambitious study to date of inner peace, namely as an item – “In general, how often do you feel you are at peace with your thoughts and feelings?” – in the Global Flourishing Study, an intended five-year study investigating the predictors of human flourishing involving (in this first year) 202,898 participants from 22 countries. This paper looks at the childhood predictors of peace, using random effects meta-analysis to aggregate all findings, focusing on three research questions. First, how do recalled aspects of a child's upbringing predict peace in adulthood, for which the most impactful factor on average was self-rated health growing up, with Risk Ratios spanning, relative to “good”, 0.93 for “poor” (95% CI [0.88,0.99]) to 1.07 for “excellent” (95% CI [1.04,1.11]). Second, do associations vary by country, with the effect of poor self-rated health spanning 0.37 in Türkiye (95% CI [0.18,0.77]) to 1.19 in Nigeria (95% CI [1.08,1.31]). Third, are relationships robust to potential unmeasured confounding, as assessed by E-values, for which the effect of poor health growing up is robust up to unmeasured confounder association risk ratios of 1.36 with inner peace. These results shed new valuable light on the long-term causal dynamics of this overlooked topic.
Research on Model Predictive Control Strategy of Three-level Dual-Active Bridge DC-DC Converter
Authors: Wang Junrui , Tan Lu , Li Jin , Ji Changjiang
Published: August 2024

A model predictive control strategy for Zero Voltage Switching (ZVS) was proposed for the mid-point clamp three-level dual Active Bridge (DAB) DC-DC converter. Through the switching conduction mode of the three-level DAB converter, the working conditions of the inductor current in each mode are analyzed, and the range of zero-voltage turn-on of all switches of the three-level DAB under single phase shift (SPS) modulation is derived. The spatial equation of state is established according to each mode, the purpose of fast response is achieved through the cost function, and finally the predictive control strategy of the three-level DAB model with zero voltage turn-on is obtained discretically. Simulation results show that the output voltage of the control strategy can be quickly stabilized under the load mutation condition when the converter realizes the zero voltage opening of all open tubes, which not only reduces the loss of the switch tubes, but also makes the system have faster dynamic response ability.
Fast-kinetics and high-compatibility aqueous cadmium-metal battery for next-generation energy storage infrastructures
Authors: Yang Hui Ying , Cui Yang-Feng , Song Haobin , Yao Jingjing , Hao Qi , Li Xue Liang , Li Yifan , Guo Binbin , Zhu Yunhai
Published: August 2024

Aqueous metal batteries have the potential to revolutionize the next-generation energy storage infrastructures due to their high energy density, high safety and low cost. However, two major issues of dendrite growth and corrosion reactions in metal anodes have hindered the deployment of this technology. To address these issues, we report an ideal candidate: aqueous cadmium-metal battery (ACB). The metal cadmium (Cd) anode not only shows a high specific capacity (476.5 mAh g-1) but also offers suitable redox potential (-0.4 V versus standard hydrogen electrode). Additionally, we introduce this ACB operating with a low-cost chloride electrolyte composed of CdCl2 and NH4Cl in water. The inclusion of NH4Cl reconstructs the hydrogen bond network of aqueous electrolyte and forms tetrachlorocomplex ([CdCl4]2-), which facilitate ultrafast reaction kinetics in ACBs and endow dendrite-free/corrosion-resistant capabilities in Cd anodes. Consequently, the tailored electrolyte achieves a convincing Coulombic efficiency (99.93%) for Cd plating/stripping behavior at a high anode utilization of 55.5%, making it suitable for practical applications. More importantly, the ACBs demonstrate outstanding compatibility paired with coordination-type, intercalation-type and capacitance-type cathodes, exhibiting excellent high-/low-rate and long-term rechargeable capabilities. On a practical note, the high-load ACB with a low negative-to-positive capacity ratio of 1.91 delivers an impressive lifespan of 800 cycles. In summary, our work suggests a practical aqueous battery capable of supporting robust energy storage infrastructures.
Expression Analysis of OsGBSSI and OsGS3 Genes, and Investigation of Morphological and Biochemical Characteristics across Diverse Rice (Oryza sativa L.) Genotypes
Authors: JAYHOON ALISINA , Kumar Pushpendra , Yadav Manoj Kumar , Kumar Mukesh , Singh Shiv Kumar
Published: August 2024

Background
Quality in the rice value chain encompasses a wide range of features and attributes that are defined by consumers based on their food preferences and habits.
Scope and approach:
we grown two aromatic basmati, one aromatic non-basmati and one non-aromatic rice genotypes during Kharif season 2021–2022 at SVP university research field for grain quality studies. Then we analyzed grain quality based on (i) morphological and physical parameters, (ii) biochemical traits, and (iii) grain quality related gene expression analysis.
Key findings and conclusion:
aromatic basmati genotypes and non-aromatic genotype shared similarities, whereas aromatic non-basmati genotype exhibited dissimilarities in terms of morphological traits. Aromatic basmati genotypes exhibited superior grain quality and yield traits, including elevated panicle length, high 1000-grain weight, extra-long slender grain, high grain elongation ratio (> 1.6), strong aroma, soft gel consistency, high alkali spreading value and intermediate amylose content as compared to both aromatic non-basmati and non-aromatic genotypes. Gene expression analysis revealed that that aromatic basmati genotype (PB-1121) had higher expression level and genotype (NVB-1) exhibited same expression level of GBSSI gene while aromatic basmati genotype showed less expression level of GS3 gene, it was 256 fold lower expression in comparison to control. Aromatic non-basmati genotype had 32 fold lower expression level of GBSSI gene and same expression level of GS3 gene as compared to control.
Identification of drought stress-responsive genes in Korean fir (Abies koreana) through comparative RNA-seq analysis
Authors: Park Hyeong Cheol , Hwang Jung Eun
Published: August 2024

Background
Abies koreana, an endangered species sensitive to drought, faces severe decline due to climate change-induced water deficit.
Results
In this study, we performed a comprehensive transcriptomic analysis of A. koreana under drought stress. RNA-seq data analysis revealed 85,403 contigs of extended lengths, indicative of a high-quality assembly. Gene Ontology classification revealed strong drought stress-responsive regulation of unigenes associated with various biological processes, cellular components, and molecular functions. Gene expression levels showed variation at different time points, indicating a nuanced plant response. Numerous transcription factors, notably those belonging to ERF, MYB, LBD, and NAC families, were identified, underscoring their critical roles in drought tolerance. Finally, qRT-PCR validation confirmed the reliability of RNA-seq data.
Conclusion
Overall, this study reveals candidate genes required for drought tolerance in A. koreana, thus supporting future tree breeding programs for effective forest management.
NOTCH1 collaborated with innate immune to regulate genomic instability caused by epigenetic enzyme deletion in cold tumor
Authors: Duan xiaojun , Zhang Mingyang , Li Kexin , Wu Rihan , Yu Lei , Bai Jing , Liu Pengxia , Wang Changshan
Published: August 2024

NOTCH1 was unfavorable to tumor immunoinfiltration in cold tumors. Targeting NOTCH1 for effective immunotherapy has been a challenge. Single cell data analysis found NOTCH1 signaling was gradually activated as lung inflammatory disease progressed. We found that NOTCH1 was highly expressed in proliferating airway epithelial cells of Lung squamous cell carcinoma (LUSC) tumor tissues. Database data analysis found NOTCH1 had adverse effects on tumor innate immunity and immune cell infiltration in LUSC.
The function of NOTCH1 was related to protein alkylation, which may caused by KDM4A and SETD2. By constructing KDM4A and SETD2 gene knockout cell lines to simulate different genomic instability cell lines. The knockdown therapy of NOTCH1 was further studied in the above cell lines. IRF3-p and IFNB1 was significantly elevated in KDM4A and NOTCH1 double-knocked down cell lines, which also with the higher DNA damage and the cell apoptosis. However, the opposite trend was seen in SETD2 and NOTCH1 double-knocked down cells, which proliferated was more faster.
Metabolomics tests showed NOTCH1 affected folate metabolism and nucleotide synthesis.
Nucleotide synthesis rate-limiting enzyme was significantly increased in KDM4A and NOTCH1 double-knocked down cell lines. Mechanically, NOTCH1 knockdown caused significant up-regulation of TBK1-p protein. NOTCH1 acted synergistically with TBK1 which depended cGAS/STING signal and ATM-p to regulate nucleotide synthesis rate-limiting enzymes. The overactived cGAS/STING signal and nucleotide synthesis rate-limiting enzymes leaded cells to apoptosis.
Oxidation Behavior of Additively Manufactured Ti-added FeCrAl Alloys
Authors: Fedorova Irina , Kjellen Mikael , Saleem Saud , Karlsson Dennis , Meurling Fredrik , Berglund Roger
Published: August 2024

Additions of titanium nitrides (TiN) can reduce cracking sensitivity of FeCrAl alloys manufactured by laser powder bed fusion through grain refinement. However, the oxidation behavior of TiN-added FeCrAl alloys is not reported up to date. In the present work, high-temperature oxidation of additively manufactured (AM) FeCrAl alloys with Ti additions from 0.5 to 1.1 w.%. has been studied in air at 1250°C during 1000 h. The AM Ti-added FeCrAl alloys have shown a higher oxidation rate than their cast reference alloy. The degradation kinetics during high-temperature exposure of the model AM alloy are described and discussed with respect to the microstructural examination. The Ti addition is shown to affect the spallation kinetics. The formation of TiN precipitates at the metal/oxide interface and their growth within the alumina scale during the exposure at 1250°C was revealed for the first time in FeCrAl material.
Use of In Situ SEM Multiple Cracking Test to Correlate Crack Propagation Mode with Acoustic Emission Signals in Thermal Oxide Scales: Application to Ni/NiO System
Authors: Houde S. , Marteau J. , Favergeon J.
Published: August 2024

Multicracking tests are carried out in an SEM on nickel specimens pre-oxidized at high temperature. These tests are monitored by acoustic emission. By combining the analysis of the acoustic emission signals with SEM observations of the specimens, it is possible to find the signatures of the two active crack propagation modes. In mode I (propagation perpendicular to the metal-oxide interface), the acoustic emission signals have high amplitudes and short durations, whereas for propagation in mode II (along the metal-oxide interface), the AE signals have low amplitudes and long durations.
Health Assessment of a 15-Minute Life Circle Around Rail Transit Based on the EWR-TOPSIS Method
Authors: Gui Wangyang , Guo Yifei , Cheng Mengnan , Xu Bin
Published: August 2024

Integrating the construction of 15-minute living circles with the TOD (Transit-Oriented Development) concept to optimize residents' travel patterns, improve healthy development levels, and form a collaborative governance and sharing structure has become a crucial issue in contemporary urban development.This paper uses the 15-minute living circles around the Hefei Metro Line 1 stations as the research object, employing the Entropy Weight Method (EWM) and the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS). Indicators were sorted from aspects of healthy travel, healthy environment, and healthy living to establish an evaluation system and quantify the health assessment of the 15-minute living circle. The findings include:1) In the spatial dimension, optimizing spatial layout enhances the competitiveness of public transportation, reduces residents' dependence on private cars, and promotes the formation of healthy travel patterns.2) In the temporal dimension, the improvement of the metro network and the increase in health facilities within the living circle diversify and facilitate residents' travel modes. Additionally, long-term construction of a healthy environment and changes in living habits help enhance overall urban health levels, creating a positive cycle.3) Optimizing the integration of the 15-minute living circle and the TOD concept requires strengthening planning and design, enhancing public transportation services, advancing healthy environment construction, promoting community participation, and implementing health education to further improve the health construction level of the 15-minute living circle.The construction of the 15-minute living circle around metro stations has driven the integrated development of metropolitan areas, enhanced the competitiveness of public transportation, and responded to the global health agenda.
Smart Irrigation for Sustainable Farming: Low- Cost IoT Solution
Authors: Akhtar Md. Amir Khusru , Sinha Prashant Kumar , Kumar Mohit , Verma Sahil , Khurma Ruba Abu , Shah Mohd Asif , Mallik Saurav
Published: August 2024

This article presents a low-cost irrigation system that harnesses the power of IoT technologies to revolutionize water management practices and enhance agricultural productivity. The system uses soil moisture sensors, climate sensors, and temperature sensors that communicate with a central controlling mechanism. The data collected from the sensors is handled with the help of machine learning algorithms to make automated decisions about irrigation. This system is useful for small-scale farmers who lack access to expensive irrigation technology. The system has undergone field trials and has shown encouraging results. The soil moisture sensors have an average error rate of below 5%, saying that the system can precisely recognize soil moisture levels. The crops grown with the smart irrigation system had a 10% greater yield than the control group, and the system was able to limit water usage by up to 30% in comparison to tradition irrigation techniques. The potential effects of the low-cost smart irrigation system on food security and agriculture in developing countries must be taken into consideration. As water resources become more expensive and scarcer, technology can change irrigation practices and enhance the development of sustainable agriculture. To adapt the system to the unique requirements of small farmers in various regions and to examine the practicality of scaling it up for wider application, more research and development are needed. All things could be done with the low-cost smart irrigation system.
Knowledge of pelvic floor muscles in community-dwelling women aged over 60: its relationship with urinary incontinence
Authors: Akkoç Yesim , Yıldız Necmettin , Yılmaz Bilge , Ersöz Murat , Bardak Ayşe Nur , Erhan Belgin , Köklü Kurtuluş , Tunç Hakan , Paker Nurdan , Özlü Aysun , Kanyilmaz Selcen , Koyuncu Engin , Alemdaroğlu Ebru , Alkan Hakan , Yumuşakhuylu Yasemin , Selbes Esra Cansu , Yıldız Ezgi , Korkmaz Nurdan , Özişler Zuhal , Yardımcı Gökhan , Akıncı Meltem Güneş , Öztekin Saadet Nur Sena , Aksungur Tuğçe , Canbulat Ahmet Tarık
Published: August 2024

Purpose: To investigate the awareness of the pelvic floor muscles (PFMs) and PFM exercises (PFME) knowledge, training and experience in community-dwelling women aged 60 and over and its relationship with urinary incontinence (UI).
Methods: This is a questionnaire based study which was carried out in 9 Physical Medicine and Rehabilitation Centers, including a total of 500 women aged 60 and over and living in the community. The questionnaire included questions about awareness of PFMs, UI complaints and PFME knowledge, training and experience. Knowledge and awareness of PFMs and PFME knowledge, training and experience were compared in subgroups with or without urinary incontinence.
Results: Knowledge and awareness of PFMs and PFME knowledge, training and experience were low in the study population. Knowledge and awareness of PFMs were significantly low in the subgroup with urinary incontinence (p<0.05). Kegel exercise training and experience were significantly low in the subgroup without urinary incontinence (p=0.01, p<0.01).
Conclusion: Knowledge and awareness of PFMs and PFME knowledge, training and experience are low in community-dwelling women aged 60 and over and training programs should be organized to teach the function of the PFMs and to perform PFME correctly in this population.