bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving phytase production in Pichia pastoris fermentations through de-repression and methanol induction optimisation
Authors: Luna-Flores Carlos H. , Weng Yilun , Wang Alexander , Chen Xiaojing , Zhao Chun-Xia , Navone Laura , Hellens Juhani von , Speight Robert
Published: July 2022

Pichia pastoris ( Komagataella phaffii) is a fast-growing
methylotrophic yeast with the ability to assimilate several carbon
sources such as methanol, glucose, or glycerol. It has been shown to
have outstanding secretion capability with a variety of heterologous
proteins. In previous studies, we engineered P. pastoris to
co-express E. coli AppA phytase and the HAC1 transcriptional
activator using a bidirectional promoter. Phytase production was
characterised in shake flasks and did not reflect industrial conditions.
In the present study, phytase expression was explored and optimised
using instrumented fermenters in continuous and fed-batch modes. First,
the production of phytase was investigated under glucose de-repression
in continuous culture at three dilution factors, 0.5 d
, 1 d , and 1.5 d
. The fermenter parameters of these cultures were
used to inform a kinetic model in batch and fed-batch modes for growth
and phytase production. The kinetic model developed aided to design the
glucose feeding profile of a fed-batch culture. Kinetic model
simulations under glucose de-repression and fed-batch conditions
identified an optimal phytase productivity at the specific growth rate
of 0.041 h . Validation of the model simulation with
experimental data confirmed the feasibility of the model to predict
phytase production in our newly engineered strain. Methanol was used
only to induce the expression of phytase at high cell densities. Our
results showed that high phytase production required two stages, the
first stage used glucose under de-repression conditions to generate
biomass while expressing phytase, and stage two used methanol to induce
phytase expression. The production of phytase was improved 3.5-fold by
methanol induction compared to the expression with glucose alone under
de-repression conditions to a final phytase activity of 12.65 MU/L. This
final volumetric phytase production represented an approximate 36-fold
change compared to the flask fermentations. This two-phase strategy
allowed to optimise phytase productivity by producing phytase during
both growth and methanol induction phases. Finally, the phytase protein
produced was assayed to confirm its molecular weight, and pH and
temperature profiles. This study highlights the importance of optimising
protein production in P. pastoris when using novel promoters and
presents a general approach to performing bioprocess optimisation in
this important production host.
Soil bacterial communities are influenced more by forest type than soil depth or slope position
Authors: Wang Yun , Xie Peng , She Jiyun , Huang Kerui , Deng Aihua , Fan Shaogang
Published: July 2022

Soil depth, slope position and different plantations can influence
bacterial community composition in Camellia oleifera forests.
However, prior studies have focused on the impacts of different depths,
slope positions, and forest types on bacterial diversity independently,
without comparing their combined impacts. This study aimed to assess
variation in soil bacterial community structures according to soil depth
and slope position and different forest types in the same plot. The
composition of soil bacterial communities was evaluated using
high-throughput sequencing of the 16S rRNA gene. Results indicate that
the soil organic carbon, humus, and total organic content increased, and
the bacterial composition and structure were significantly altered in
response to the G. jasminoides + C. oleifera low-yielding forest
in comparison to the other three forest types. The highest soil bacteria
numbers, Alpha and beta diversity, which improved the soil
microecological environment, were associated with the G.
jasminoides + C. oleifera forests and not the depth or slope position
treatments. The slope position did not have a significant influence on
the soil physicochemical and bacterial properties. Structural equation
modeling suggested that G. jasminoides + C. oleifera
significantly affected the soil bacterial community diversity by
mediating the soil pH and NH –N. The effects of forest
type on soil bacterial diversity were more important than soil depth and
slope position. This specific intercropping system was found to be an
effective strategy to improve soil health.
Future perspectives in breeding the indigenous local Stara Zagora sheep and improving the phenotypic and genetic parameters of the breed
Authors: Kalaydzhiev Georgi
Published: July 2022

One of the most phenotypically attractive breeds in Bulgaria is the local
Stara Zagora sheep. It is a local - indigenous breed specialized in dairy
direction. In recent years, this valuable genetic resource is on the verge
of being lost as the breed is threatened with extinction. The aim of the
study is to monitor the genetic and phenotypic parameters of the main
reproductive and productive traits in local Stara Zagora sheep.The research
includes a total of 9495 ewes of the local Stara Zagora breed reared in 15
farms, produced during the period from 2011 to 2020 including. The studied
traits were: fertility - biological of the first, second and third lambing,
milk yield for a 120-day period of first, second and third standard
lactation and live weight of different age categories. The statistical model
that we used was based on the model of animal /Animal model/, using the
software product PEST and VCE (Groeneveld), SYSTST 13 and SPSS for
Descripive statistics. The average phenotypic values of the traits: are
respectively - fertility of 1st - 113%, 2nd - 125% and 3rd - 129% lambing;
live weight of weaning - 29.79 kg, at 18 months - 63.87 kg, and at 2.5 years
72.92 kg; milk yield of the 1st - 98.37 l; 2nd - 104.60 l and 3rd - 108.80
l. lactation. Heritability (h?) in the main selection traits milk yield of
the first, second and third lactation is characterized by moderate values -
0.191; 0.225 and 0.184, respectively, and we report from low to moderate
values of h? on the fertility in all three studied groups - fertility in the
1st - 0.183; 2nd - 0.149 and 3rd lambing 0.137. Milk yield is in high
positive correlation and with a high statistical significance at different
stages of lactation, between the 1st and 2nd - 0.849, between the 2nd and
3rd - 0.628 and between the 1st and 3rd - 0.447.
Analysis of vitality and biochemical parameters in freeze-thawed seminal plasma of rams
Authors: Cekic Bogdan , Kanzova Hristiyana , Petrov Georgi , Maksimovic Nevena , Cosic Ivan , Milovanovic Aleksandar
Published: July 2022

The current study aimed to examine the percentage changes of viability sperm
and the activity of the enzymes LDH, ALP, GOT / AST, GPT / ALT in the sperm
plasma of Lacaune rams, before and after cryopreservation. For this purpose,
five rams were examined, and two ejaculates were obtained from each ram.
Ejaculates are collected by the method of artificial vagina, during the
insemination campaign. All ejaculates were diluted with a 6AG extender and
frozen by the Cassou?s sequin method. Sperm viability was determined by
eosin and nigrosine smears, and enzyme activity was examined
spectrophotometrically. As a result, the percentage of vital sperm after
cryopreservation decreased by 15% (P ? 0.001). The freezing and thawing
process also reduced the activity of the enzymes LDH, ALP, GOT / AST and GPT
/ ALP. In conclusion, the observed enzymes, in relation to sperm vitality,
could be used as indicators to optimize the protocols for cryopreservation
of ram?s sperm.
Canonical almost geodesic mappings of the first type onto generalized Ricci symmetric spaces
Authors: Berezovski Vladimir , Cherevko Yevhen , Hinterleitner Irena , Mikes Josef
Published: July 2022

In the paper we consider canonical almost geodesic mappings of spaces with
affine connection onto m-Ricci-symmetric spaces. In particular, we studied
in detail canonical almost geodesic mappings of the first type of spaces
with affine connections onto 2- and 3-Ricci-symmetric spaces. In either case
the main equations for the mappings have been obtained as a closed mixed
system of PDEs of Cauchy type. We have found the maximum number of essential
parameters which the solution of the system depends on.
Two families of separation axioms on infra soft topological spaces
Authors: Al-Shami Tareq , Mhemdi Abdelwaheb
Published: July 2022

Many generalizations of soft topology were studied in the literature, an
infra soft topology is the recent one of these generalizations. In this
paper, we put on view two classes of soft separation axioms in the frame of
infra soft topologies, namely infra pp-soft Tj and infra pt-soft Tj-spaces
(j = 0, 1, 2, 3, 4). Both of them are formulated with respect to distinct
ordinary points such that the first class defined using partial belong and
partial non-belong relations, and the second one defined using partial
belong and total non-belong relations. Following systematic lines of this
type of study, we first show the relationships between them with the aid of
examples. We also establish main properties and explore their behaviour
under some special types of infra soft topologies. Transmission of these
classes between infra soft topology and its parametric infra topologies are
amply studied. Moreover, we scrutinize their features in terms of hereditary
and topological properties, and finite product of soft spaces.
Quasi-Yamabe solitons and almost quasi-Yamabe solitons on lightlike hypersurfaces
Authors: Arfah Arfah
Published: July 2022

In the present paper, we study the quasi-Yamabe solitons and almost
quasi-Yamabe solitons on the lightlike hypersurfaces of the semi-Riemannian
manifolds endowed with a torse-forming vector field. We show some conditions
for the lightlike hypersurfaces to be quasi-Yamabe solitons and almost
quasi- Yamabe solitons with the tangential component of the torse-forming
vector field on the semi-Riemannian manifolds as the soliton field. In
particular, we also specify the conditions for lightlike hypersurfaces of (n
+ 2)-dimension semi-Riemannian manifolds of constant curvature to be
quasi-Yamabe solitons and almost quasi-Yamabe solitons. Besides, we provide
some geometric properties of the lightlike hypersurfaces satisfying
quasi-Yamabe solitons, quasi-Yamabe gradient solitons, almost quasi-Yamabe
solitons and almost quasi-Yamabe gradient solitons. Furthermore, we
investigate properties of screen homothetic lightlike hypersurfaces
admitting quasi-Yamabe solitons and almost quasi-Yamabe solitons.
A new characterization of the closure of Dirichlet type spaces Ds in Bloch spaces and interpolating Blaschke product
Authors: Hao Shangjing , Yang Liu
Published: July 2022

In this paper, motivated by Qian, et al [20, 22], we give a new
characterization for the closure of the space Ds in the Bloch space.
Riemann solitons on almost co-Kähler manifolds
Authors: Biswas Gour , Chen Xiaomin , De Uday
Published: July 2022

The aim of the present paper is to characterize almost co-K?hler manifolds
whose metrics are the Riemann solitons. At first we provide a necessary and
sufficient condition for the metric of a 3-dimensional manifold to be
Riemann soliton. Next it is proved that if the metric of an almost
co-K?hler manifold is a Riemann soliton with the soliton vector field ?,
then the manifold is flat. It is also shown that if the metric of a (?,
?)-almost co-K?hler manifold with ? < 0 is a Riemann soliton, then the
soliton is expanding and ?, ?, ? satisfies a relation. We also prove that
there does not exist gradient almost Riemann solitons on (?, ?)-almost
co-K?hler manifolds with ? < 0. Finally, the existence of a Riemann soliton
on a three dimensional almost co-K?hler manifold is ensured by a proper
example.
Numerical radius inequalities for products and sums of semi-Hilbertian space operators
Authors: Bhunia Pintu , Feki Kais , Paul Kallol
Published: July 2022

New inequalities for the A-numerical radius of the products and sums of
operators acting on a semi-Hilbert space, i.e. a space generated by a
positive semidefinite operator A, are established. In particular, for every
operators T and S which admit A-adjoints, it is proved that ?A(TS) ? 1/2?A(ST) + 1/4 (||T||A||S||A + ||TS||A), where ?A(T) and ||T||A denote the
A-numerical radius and the A-operator seminorm of an operator T
respectively.
Importance, personal protective equipment, and our experience after first autopsies performed on Covid-positive deceased in Novi Sad, Serbia
Authors: Vapa Dusan , Maletin Miljen , Radosavkic Radosav , Sabo-Ilic Jelena , Vasiljevic Milena , Lakic Tanja
Published: July 2022

Introduction/Objective. Autopsy represents the gold standard for determining cause and mechanisms of death. With this paper, the authors wanted to acquaint colleagues with our experiences while performing autopsies of COVID-positive deceased patients. Method. The study included total of 12 autopsies related to COVID-19 infection, performed in our forensic pathology institution, from which one autopsy of suspected patient and 11 autopsies of confirmed COVID-positive patients. Confirmation of infection was obtained by antemortem polymerase chain reaction analysis of oropharyngeal and nasopharyngeal swabs and by postmortem swabs taken from upper airways and lungs. Results. In five cases, cause of death was directly attributed to COVID-19 infection. In two cases cause of death was due to heart attack, in two cases due to gastrointestinal hemorrhage, in one case due to multiple injuries, in one case due to trauma complications and in one case due to gunshot injury. Conclusion. Large number of autopsies in which cause of death has been established to be other than COVID, along with importance of these cases for litigation, strongly emphasizes the importance of forensic autopsy of COVID-positive deceased. If adequate personal protective equipment is used, there should be minimal exposure risk to virus remaining in body tissues.
Infection prevention and control protocols in dentistry - Canadian guidelines
Authors: Stojicic Sonja , Obrenovic Vladimir
Published: July 2022

Introduction. A risk of transmission of infectious diseases has always been
an inherent part of dental practice. Easily communicable respiratory and
blood borne diseases have prompted dental communities to establish,
evaluate, update and monitor infection prevention and control (IPAC)
protocols and strategies (guidelines). The aim of this paper was to present
Canadian standard protocols of infection prevention and control in dental
offices, and compare them with similar guidelines available to dentists in
Serbia. Method. A detailed overview of the most current IPAC guidelines and
protocols provided by the College of Dental Surgeons of British Columbia in
Canada has been summarized. In addition, the effect of the most recent
Covid-19 pandemic on the current infection prevention and control measures
in dental offices and future perspectives has been reviewed. Conclusion.
Implementing infection prevention and control guidelines is essential part
of practicing dentistry. Regulatory authorities have responsibility to
establish and provide dentist with the most current IPAC protocols while
dentists need to adopt up-to-date procedures and appropriately and
consistently use them in everyday practice.
Victimological review of peer violence in the digital environment
Authors: Miric Filip , Vasiljevic-Prodanovic Danica
Published: July 2022

Using information and communication technologies is one of the basic
competencies of modern people. The Internet has enabled the download and
sharing of data in digital form, learning, information, business,
entertainment, and inclusion in social networks. However, the development of
the Internet has also led to the emergence of various forms of digital
violence. Minors who cannot adequately react to this violence are
particularly susceptible to victimisation. The subject of this paper is the
phenomenon of peer violence in the digital environment, viewed from a
victimology perspective. The paper presents the basic phenomenological
characteristics of this form of violence and the typology of victims and
perpetrators. This paper aims to point out the importance of a victimology
approach to the problem of cyber violence and the need to implement programs
to prevent violence and protect victims of peer violence in the digital
environment. By comparing the characteristics of perpetrators and victims in
the digital environment, we can gain valuable insights that can contribute
to the prevention of this form of peer violence.
Modelling Long-Term Outcomes and Risk of Death for Patients with Post-Stroke Spasticity Receiving Abobotulinumtoxina Treatment and Rehabilitation Therapy
Authors: Fheodoroff Klemens , Danchenko Natalya , Whalen John , Balcaitiene Jovita , Magalhães Barbara , Szulc Elzbieta , Zaffalon Andrea , Burchakova Mariya , Nechiporenko Dmitry , Robbins Sean
Published: July 2022

Objective: Stroke is associated with a high risk of death and cardiovascular events. Rehabilitation therapy is critical for functional recovery, to reduce hospital readmissions, all-cause and cardiovascular mortality, and stroke recurrence (long-term outcomes). Post-stroke spasticity may prevent effective recovery by restricting mobility. AbobotulinumtoxinA is an adjunctive therapy to physical therapy for post-stroke spasticity, but its long-term effects are unknown. The objective was to model the long-term clinical and economic outcomes of abobotulinumtoxinA for post-stroke spasticity.Methods: Effects of abobotulinumtoxinA on treating post-stroke spasticity and evidence linking functional outcomes with long-term outcomes were collected in a focused literature review. A model was developed to estimate health benefits on long-term outcomes, direct medical costs, life- and qualityadjusted life-years for abobotulinumtoxinA injections plus rehabilitation therapy compared with rehabilitation therapy alone, from a UK perspective over a 10-year time-period.Results: AbobotulinumtoxinA + rehabilitation therapy led to a risk reduction of 8.8% for all-cause mortality, and an increase of 13% in life-years and 59% in quality-adjusted life-years compared with rehabilitation therapy alone. AbobotulinumtoxinA + rehabilitation therapy was considered cost-effective compared with rehabilitation therapy alone (incremental cost-effectiveness ratio: £24,602).Conclusion: AbobotulinumtoxinA + rehabilitation therapy may improve long-term outcomes, including post-stroke survival, while being cost-effective for the treatment of post-stroke spasticity.
LAY ABSTRACTHere we developed a model to explore and compare the long-term benefits and overall costs of two interventions for the treatment of post-stroke spasticity (PSS): abobotulinumtoxinA injections plus rehabilitation therapy (aboBoNT-A+RT) vs. RT alone. Stroke survivors are known to be at a higher risk of recurrent stroke and death, and more than 25% are affected by spasticity. PSS significantly reduces patients’ mobility, physical functioning, and subsequently their ability to recover after a stroke. AboBoNT-A+RT is an effective treatment for spasticity. This model is the first to highlight that combining aboBoNT-A injections with RT could improve the overall survival of stroke survivors with spasticity by 8.8% and their overall quality of life, while being considered good value for money by UK payers.
A Comparison of Two Stool Positions for Stabilizing a Dental Chair During CPR
Authors: Hitosugi Takashi , Awata Norimasa , Miki Yoichiro , Tsukamoto Masanori , Yokoyama Takeshi
Published: July 2022

Objective:

Most dental chairs lack sufficient stability to perform effective manual chest compression (MCC) during cardiopulmonary resuscitation (CPR). A stabilizing stool can significantly reduce backrest vertical displacement in all chair types; however, a severely curved exterior backrest may negatively impact the stool's effectiveness. This study evaluated the efficacy of 2 stool positions for stabilizing a dental chair during MCC.

Methods:

Chest compressions were performed on a manikin positioned in a dental chair while vertical displacement of the chair backrest during MCC was recorded using video and measured. Vertical displacement data were captured with no stool and with a stabilizing stool in 2 different positions. Reduction ratios were calculated to evaluate the effectiveness of the 2 stool positions.

Results:

With no stool, the backrest median (interquartile range) vertical displacement during chest compressions was 16.5 (2.5) mm as compared with 12.0 (1.5) mm for the stabilizing stool positioned under the area of MCC and 8.5 (1.0) mm under the shoulders. The stool positioned under the shoulders produced a significantly increased calculated reduction ratio of 48% (14%) compared with 27% (20%) under the area of MCC (P < .001).

Conclusions:

Positioning a stabilizing stool under the shoulders was more effective at reducing vertical displacement of the dental chair backrest during chest compressions than positioning the stool under the area of MCC.
CONTRIBUTION TO THE KNOWLEDGE OF THE ZYGAENIDAE (LEPIDOPTERA) OF TURKEY
Authors: CAN Feza , ULAŞLI Başak , KARAÇETİN Evrim , AKAR Serdar
Published: July 2022

The aim of this article is to contribute to the recent distribution and systematic classification of Zygaenidae (Lepidoptera) in 12 provinces in the Aegean, eastern Anatolia and Thrace regions of Turkey, with the records obtained in 2020 and 2021. Twenty Zygaenidae species from five genera belonging to Procridinae and Zygaeninae subfamilies were recorded: Theresimima Strand, 1917 (1 species), Rhagades Wallengren, 1863 (1 species), Adscita Retzius, 1783 (1 species), Jordanita Verity, 1946 (5 species), and Zygaena Fabricius, 1775 (12 species). It is the first record of Zygaena (Zygaena) ephialtes (Linnaeus, 1767) in Thrace region of Turkey since Herrich-Schäffer (1845). Zygaena (Mesembrynus) lydia Staudinger, 1887 endemic to Turkey, was also recently recorded in this study. In addition, Zygaena (Agrumenia) armena Eversman, 1851, which is known only in Turkey and Georgia, was also recorded from the province of Ardahan in the eastern Anatolia region of Turkey.
Design of Affordable Cold Storage for Horticulture Products (Urban Farming “Mom's Farm” in Sampora Village)
Authors: Suprata Ferdian , Natalia Christine , Setyanto Djoko , Kartadinata Budi , Principall Victoria
Published: July 2022

Growing the world’s population to almost 9.7 billion by 2050 will continue to address the challenges facing the food and agriculture sector. The aim of this study is to reduce food losses in Sampora Village, Cisauk – South Tangerang by creating an affordable cold-storage of Modified Atmosphere Storage (MAS) equipment with a capacity of 4.77 m3 so that it can increase the quality of food for a longer period without deterioration of the horticultural products stored. Temperature control, humidity control, air circulation, maintenance of space between containers for adequate ventilation, total capacity, dimensions, efficiency, development costs, durability, performance, and features are involved in the design. This cold storage is designed with a Design Thinking method. A qualitative research was conducted through interviews to gain insight and synthesize the needs. The selection prototype concept was chosen by the Pugh Matrix and finally this study proposed in an affordable cold-storage technology.
Integrating Immersive Experiences to Instruction through BreakoutEDU
Authors: Kwong Vincci , Falzon Judith , Feighery Julie
Published: July 2022

This study employed an escape room motif to engage students to use information literacy course material to solve puzzles. Students practiced research techniques in a classroom environment that bypassed their expectations of traditional course instruction. Instructor objectives were to increase student engagement with the course material, and to foster teamwork among students in a cooperative learning environment. Authors initially obtained 9 kits from Breakout EDU, a company specializing in immersive games. Games were devised for three of the course units, with each unit identifying 4-5 information literacy skills or concepts. The puzzles were focused on reinforcement of the key concepts. After each escape room class session, students completed a short survey. At the end of the semester students completed another survey about their experiences. Over 80% of students indicated the games helped them understand course concepts. Comparisons of final grades in the gamified courses with previous, non-gamified courses revealed that students achieved more A’s and fewer D’s and F’s in the gamified courses.  Future directions for study include flipping game design to student groups, and further analysis of correlations between concepts learned through traditional teaching techniques and those learned in Breakout EDU classes.
Impact of COVID-19 on Academic Library Service Delivery in Zimbabwe
Authors: Chigwada Josiline
Published: July 2022

The higher and tertiary education system was greatly affected by the COVID-19 pandemic leading to tremendous changes in service delivery in academic libraries. All the higher education stakeholders were affected including lecturers, students, researchers, and librarians, and they were forced to adjust accordingly in order to remain relevant. A survey was done using a multiple case study design where online questionnaires were distributed and participant observation were used to collect data from three academic libraries in Zimbabwe. It was discovered that academic libraries changed the way they deliver their services to meet the new demands when teaching and learning was shifted to online as a way of curbing the spreading of the virus. The author recommends that academic librarians should be continuously trained to deal with the skills gap created by the COVID-19 pandemic. There is need to provide appropriate information and communication technology infrastructure and the supporting policies and guidelines for academic libraries to continue supporting the research, teaching and learning activities in the COVID-19 environment.
Eksistensi Tokoh Sulis dalam Novel Dunia Sunyi Karya Achi TM
Authors: Kharisma Talitha Lulu , Andalas Eggy Fajar
Published: July 2022

The study examined the novel of the silent world by achi tm by using the feminine theory of existentialism and female concept of image. Feminism existentialism is a stream of feminists that trivialize the existential problems of women. This study is included in a descriptive type of research. Data-collection techniques using note-reading techniques. The note-reading technique involves a reoccurring book of the silent world by achi tm to retrace the events that occurred as research data and are used to analyze. As for those data analysis techniques are as follows. 1) reviewing the data already collected, 2) regrouping data according to the issue of female image and female form of struggle in the private and public sphere, 3) interpreting data with existing theories, 4) concluding the findings. Research shows that the novel of the silent world by achi tm shows the image and struggle of the female figure, among other things: (1) the image of women is depicted physically by body and psyche and by virtue of abstinence, faithfulness, weakness, patience, and forgiveness; (2) the existence of a female figure is found through the struggle of a female figure in a good private and public domain.
Efektivitas Metode Diskusi pada Pembelajaran Teks Berita pada Kelas VIII
Authors: Maula Zulfatul , Setyonegoro Agus , Akhyaruddin Akhyaruddin
Published: July 2022

The use of learning methods that are not in accordance with the learning objectives are often an obstacle in achieving the formulated learning objectives. This research is expected to be a reference for improving and selecting effective and efficient learning methods in learning news texts at the junior high school level. The type of research used is experimental research that uses the experimental results of the pretest-posttest design. This research was conducted at Al-Azhar Junior High School IT Jambi City in February-March 2022. Based on the analysis that has been carried out, it can be said that the use of the discussion method applied to learning Indonesian for news text material results in better results than those who do not use the discussion method. The use of the discussion method can make the classroom situation in learning more effective so that it can motivate learning and the learning material will be easier for students to understand. The results of the t-test showed that there was a significant effect of the use of the discussion method on learning news texts at the junior high school level.
Digitalization in higher education institutions: the case of Selcuk University and Matej Bel University
Authors: Cankaya Seda Kurnaz , Nafoussi Gabriela
Published: July 2022

The revolutionary progress in technology has started a transformation process that is reshaping the world. The aim of this transformation, which has digitalization at its center, is to facilitate human life and increase productivity by using the latest technologies. In order to benefit from the innovations of the digital age, many other fields such as transportation, education, health and tourism have become involved in this transformation process. In this context, COVID-19 accelerated the digital transformation in higher education and caused the intensive adoption of new technologies. In the light of this information, the aim of this research is to analyze how the students at Selçuk University and Matej Bel University perceive digitalization of their university. At the same time, it identifies the challenges and benefits of digitalization from the students and universities point of view. The opinion of students on the digital transformation process will be able provide a view of both the progress made by universities and what is needed in the future.
Modern diagnostics and treatment of distant metastasis of cervical cancer
Authors: Minyazeva R. K. , Battalova G. Y. , Sakhautdinova I. V. , Gilyazova I. R.
Published: July 2022

Cervical cancer comprises a major female health problem worldwide. Despite population screening programmes, broad vaccination, precision pathogenesis studies and emergent diagnostics and treatment strategies, its prevalence is rising by year. We increasingly report the spread of disease, particularly of metastatic cervical cancer. The such patients’ prognosis is far from favourable. We review the literature relevant to diagnostic and treatment options in metastatic cervical cancer. The options and survival rates described vary by the locality of metastatic lesions and routes of metastasis. Patients with haematogenous metastases have a worse prognosis than patients with lymphogenous ones. From a diagnostic point of view, 2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG PET) and PET-computed tomography remain efficacious for detecting distant metastases. Adjuvant chemotherapy and concurrent chemoradiotherapy are effective in lymphogenous metastases. Haematogenous lung metastases resection and/or chemotherapy are the tactics of choice to contain relapsed metastatic cervical cancer. Accordingly, chemoradiotherapy is the optimal choice in patients with stage IVB cervical cancer. Multimodal therapy has revealed better survival prognosis. Stereotactic radiosurgery or craniotomy is indicated in oligometastatic brain lesions, with treatment outcomes and survival rates improving for the techniques’ combination with whole-brain radiation therapy. However, in multiple metastasis to brain or extracranial metastasis, chemotherapy combined with palliative whole-brain radiation are left as the only option.
English Education Master Students' Perceptions on Online Learning During COVID-19 Pandemic
Authors: Wijaya Kristian Florensio
Published: July 2022

AbstractELT enterprises are always ever-changing in these recent years due to the learners’ learning needs, preferences, interests, and proficiency. This progressive change is noticeable during this covid-19 pandemic where all educational institutions are commissioned their learners to study from home with the support of technological interfaces. This current small-scale qualitative study was an attempt to discover the specific perspectives upheld by English Education Master Students concerning the internalization of online EFL learning activities during these recent 2 year periods. To fulfill this research objectivity, the narrative inquiry was employed to fully attain the authentic data derived from the research participants manifested in the form of stories. In the short-term data gathering processes, 5 open-ended written narrative inquiry questions were distributed to 2 English Education Master Students of Sanata Dharma University, batch 2020. Anchored on the obtained research results, online EFL learning activities are quite beneficial in promoting more fruitful learning outcomes and embracing learners’ learning pace in absorbing the imparted learning materials. Hence, it is worth highlighting that this learning method is appropriately suitable for nowadays target language learning venture due to its practicality and feasibility. Some specific suggestions were also depicted in the last section.Keywords: Online learning; graduate students; covid-19 pandemic
DEVELOPMENT OF A SMART DOLL PROTOTYPE FOR EARLY AGE CHILDREN COLOURS LEARNING IN THREE LANGUAGES
Authors: Kurniastuti Irine , Widiarti Anastasia Rita , Nugroho Robertus Adi , Pinaryanto Kartono
Published: July 2022

Early childhood is a golden age to learn a language, not only the mother tongue but also a second or third language. However, learning media that can be used to attract children's interest in learning multi-language is still limited. Therefore, this study aims to develop a smart doll that attracts children to learn Javanese, English, and Indonesian. In particular, this media is intended to help children recognise colours in three languages. This research is developmental research with the following steps: First, collecting information about the product being developed, conducting a literature review and interviewing teachers and parents. Second, planning product design in accordance with the results of the needs analysis. Third, developing the initial product form. Fourth, conducting a preliminary field test on 3 children. Fifth, revising the main product. Sixth, field testing on eight children. Seventh, evaluate the testing result for the next development plan. The result of this research is a prototype of a smart doll that is able to recognize colours in 3 languages. Based on the field trials results, the prototype of this smart doll can attract children’s enthusiasm for learning colours and improve their ability to recognise colours in three languages. Some things that need to be improved will be discussed further.
INTERROGATING THE PURPOSE OF SECONDARY EDUCATION IN ETHIOPIA: RHETORIC AND REALITY
Authors: Negesso Lemessa Abdi
Published: July 2022

The study examined the prevailing purpose of secondary education. Interview, questionnaire and observation are the tools used to collect data from curriculum experts, secondary school leaders, teachers, students and classrooms. Independent t-test was used to analyze quantitative data. Qualitative data obtained through interview, observation, and document analysis were analyzed using narrative description. Though the results from analysis of the Education Policy and related documents indicated the purpose of secondary education is to prepare students both for the world of work and for further education, key stakeholders perceived preparation for national examinations and higher education as the major intent of secondary education. It was found that experts, educators and students had no adequate understanding about the half part mission of secondary education, preparation for work. It was also found that the curriculum wasn’t designed to prepare students for work and teacher centered approach was the dominant pedagogical strategy employed in the schools. As a result, it is concluded that the prevailing purpose of secondary education is to prepare students for examination and higher education. It was suggested to enhance key stakeholders understanding about the entire purpose of secondary education and to revise the curriculum in use and pedagogical practices of the schools.
PERANCANGANAPLIKASI PENGOLAHAN DATAPASIEN RAWAT JALAN PADA UPTD PUSKESMAS BUMI EMAS LAMPUNGTIMUR
Authors: Puspita Sari Rizki Arida , Sudarmaji Sudarmaji , Irawan Dedi
Published: July 2022

Rawat Jalan adalah pelayanan medis kepada seorang pasien untuk pengobatan yang dilakukan tanpa pasien menginap di rumah sakit. Berdasarkan penelitian yang dilakukan, diperoleh informasi bahwa proses pengolahan data pasien rawat jalan masih menggunakan pencatatan ke dalam buku besar. Kelemahannya adalah jika melakukan pencarian data pasien rawat jalan di dalam buku besar membutuhkan waktu yang cukup lama. Jika suatu saat buku tersebut hilang, maka akan menyulitkan dan memperlambat staff pendaftaran dalam pencarian data pasien rawat jalan.Tujuan dari penelitian yang dilakukan pada UPTD Puskesmas Bumi Emas Lampung Timur adalah merancang aplikasi pengolahan data pasien rawat jalan pada UPTD Puskesmas Bumi Emas Lampung Timur.Metode penelitian yang digunakan penulis terdiri dari dua bagian, yaitu metode berdasarkan jenis penelitian (Applied Research) dan teknik pengumpulan data pengamatan (observasi), wawancara (interview), dokumentasi (documentation) dan studi kepustakaan (library research). Aplikasi dirancang menggunakan pendekatan pemrograman terstruktur yang berbasis desktop, dengan teknik pengujian aplikasi menggunakan teknik Black Box Testing. Bahasa pemrograman yang digunakan adalah Java NetBeans, dengan database MySQL dan report menggunakan iReport. Alat pengembangan sistem yang digunakan antara lain flowchart, dfd, erd.
PERANCANGAN WEBSITE INFORMASI PADA KANTOR URUSAN AGAMA (KUA) PUNGGUR LAMPUNG TENGAH
Authors: Rizqi Habib Afridoansyah , Sudarmaji Sudarmaji , Dupri Muhammad Demsi
Published: July 2022

Website Adalah kumpulan dari beberapa halaman yang berisi dan menampilkan informasi berupa data gambar, suara, teks, animasi, vidio atau bisa juga gabungan dari semuanya. Berdasarkan penelitian yang dilakukan, diperoleh informasi bahwa cara penyampaian berita dan informasi dari KUA kepada masyarakat masih sangat manual dan terbatas saat ini media yang di gunakan adalah dengan cara bertanya langsung, melalui media cetak, atau dengan telfon. Kelemahannya adalah Media ini kurang efektif karena akan sangat menghambat informasi atau berita yang akan disampikan, terutama letak kantor yang tidak semua orang yang berkepentingan tempat tinggalnya dekat dengan kantor tersebut, terlebih lagi jika pegawai sulit di hubungi dan media cetak yang bisa rusak, hal ini tentunya akan sangat menghambat penyampaian cerita atau informasi. Tujuan dari penelitian yang dilakukan pada KUA Punggur Lampung Tengah adalah Melakukan inovasi terutama di media penyampaian informasi, serta untuk merancang dan membuat website di KUA Punggur Lampung Tengah. Metode penelitian yang digunakan oleh penulis terdiri dari dua bagian, yaitu metode berdasarkan jenis penelitian (Applied Research) dan teknik pengumpulan data pengamatan (observasi), wawancara (interview), dokumentasi (documentation) dan studi kepustakaan (library research). Metode pengembangan aplikasi menggunakan SDLC (System Development Life Cycle) dengan teknik pengujian aplikasi menggunakan teknik Black Box Testing. Bahasa pemrograman yang digunakan adalah Php, dengan framework Codeigniter, serta database MySQL. Alat pengembangan sistem yang digunakan antara lain diagram konteks, dfd, erd, dan flowchart. Berdasarkan permasalahan tersebut, maka dibutuhkan sebuah website informasi sebagai media penyampaian informasi yang cepat dan akurat. Sehingga pada penelitian ini menghasilkan sebuah keluaran aplikasi Perancangan Website Informasi Pada Kantor Urusan Agama (KUA) Punggur Lampung Tengah. Fitur website informasi ini berupa berita, informasi, download dokumen, komentar, serta call center ke admin KUA.
PEMILIHAN DAERAH PENERIMA BANTUAN PUSAT PENGENDALIAN OPERASI MENGGUNAKAN ANALYTICAL HIERARCHY PROCESS PADA PUSDATINKOMBEN BNPB
Authors: Leonard Leonard , Iqbal Mohammad
Published: July 2022

Pusat Pengendalian Operasi Penanggulangan Bencana (Pusdalops PB) adalah sebuah Pusat Pemantauan kondisi alam dan aktivitas terhadap potensi bencana pada daerah-daerah yang memiliki risiko tinggi terhadap bencana alam. Informasi terkait dengan bencana perlu dikumpulkan, diproses, dianalisis dan selanjutnya disusun laporan serta diseminasinya. Informasi kebencanaan di sini tidak hanya menyangkut kejadian bencana, namun juga upaya penanganan yang dilakukan oleh berbagai pihak baik saat prabencana maupun pasca bencana.  Permasalahan pada penelitian ini adalah Pemberian Bantuan Pusat Pengendalian Operasi Penanggulangan Bencana (Pusdalops PB) adanya penilaian yang bersifat subyektif oleh tim penilai kelayakan daerah penerima bantuan. Sehingga daerah-daerah yang benar-benar layak mendapatkan bantuan Pusat Pengendalian Operasi Penanggulangan Bencana (Pusdalops PB) menjadi tidak mendapatkan bantuan. Solusi dari permasalahan tersebut adalah dengan menggunakan algoritma Analytical Hierarchy Process (AHP) yang diaplikasikan kedalam sebuah sistem penunjang keputusan dan uji kelayakan aplikasi menggunakan ISO 9126. Sehingga hasil dari penelitian ini adalah sebuah aplikasi sistem penunjang keputusan yang mampu memberikan keluaran berupa perangkingan kepada daerah-daeran calon penerima bantuan. . Hasil dari aplikasi menggunakan 3 buah data daerah penerima bantuan menunjukan nilai tertinggi sebesar 0.535 dan terendah 0.156
ANALISIS PENGGUNAAN UANG NON TUNAI (CASHLESS) GO-PAY DAN PROSES BISNISNYA PADA TRANSPORTASI ONLINE GO-JEK DENGAN METODE ROOT CAUSE ANALYSIS
Authors: Suryono Ali Muchtar , Supono Riza Adrianti
Published: July 2022

Go-Jek menciptakan suatu trobosan baru dimana pelanggan ojek tidak perlu lagi pergi ke pangkalan ojek untuk mendapatkan ojek. Pelanggan dapat memanggil ojek dengan cepat, harga termurah, tanpa beranjak dari tempat mereka berada. Apalagi ditambah dengan adanyauang elektronik Go-Pay, pelanggan tidak harus repot-repot menyediakan uang tunai. Banyaknya kemudahan dan manfaat yang dirasakan oleh konsumen Go-Jek dari adanya fitur Go-Pay, membuat banyak konsumen yang berminat menggunakan transportasi Go-Jek. Tujuan penelitian ini adalah untuk mengetahui penggunaan uang non tunai (cashless) Go-Pay dalam aplikasi Go-Ride pada transportasi ojek online Go-Jek dan proses bisnisnya menggunakan metode analisis Root Cause Analysis (RCA) dengan langkah-langkahnya yaitu pengumpulan data, pemetaan faktor kausal, identifikasi root cause, dan perumusan rekomendasi. Hasil penelitian yang diperoleh adalah pada faktor manfaat, indikator yang perlu mendapatkan perhatian dari Go-Pay adalah memberikan keuntungan tambahan saat menyelesaikan transaksi dan meningkatkan efisiensi dalam melakukan transaksi sehingga perlu dilakukan evaluasi dan perbaikan. Pada faktor kemudahan, indikator yang perlu mendapatkan perhatian dari Go-Pay adalah indikator jelas dan mudah dimengerti, tidak dibutuhkan banyak usaha, mudah digunakan dan mudah dioperasikan dan cepat mahir sehingga perlu dilakukan evaluasi dan perbaikan. Evaluasi dan perbaikan menggunakan Root Case Analysis (RCA) dengan metode “5Why’s” dan menggunakan Failure Mode and Effect Analysis (FMEA). Perbaikan yang telah dilakukan oleh Go-Jek adalah sistem Go-Pay diamankan oleh Gojek SHIELD, Go-Pay telah mendapatkan sertifikasi ISO 27001:2013 Information Security Management System - ISMS atau Sistem Manajemen Keamanan Informasi. Go-Pay memberikan berbagai fitur tambahan melalui Go-Pay Plus yaitu proteksi ekstra untuk saldo Go-Pay, limit lebih besar, kirim-kirim saldo Go-Pay, transfer ke rekening bank, Benefit PayLater, dan Promo eksklusif.
SISTEM INFORMASI WEBSITE SEBAGAI MEDIA PROMOSI DAN SARANA INFORMASI PADA RUMAH SAKIT MARDI WALUYO METRO
Authors: Istiqomah Nurul , Hidayat Arif
Published: July 2022

Rumah Sakit Mardi Waluyo Metro merupakan salah satu instansi yang bergerak dibidang kesehatan, sehingga diperlukan suatu media promosi dan sarana informasi berbasis website yang menampilkan informasi seputar RS. Mardi Waluyo Metro.  Sistem pada RS. Mardi Waluyo Metro sudah terkomputerisasi dengan baik, penyampaian informasi juga sudah baik, yaitu dengan brosur, via handphone, dan dari satu pihak ke pihak lainnya.  Tetapi penyampaian informasi dari segi teknologi belum maksimal akibatnya dalam proses penyampaian informasi ini ada beberapa masyarakat yang belum mengetahui tentang informasi terbaru.  Maka permasalahan dalam pembuatan laporan tugas akhir ini dapat dirumuskan yaitu: “Bagaimana merancang dan membuat desain website dinamis sebagai media promosi dan sarana informasi pada RS. Mardi Waluyo Metro, Menggunakan media online sebagai sarana untuk mempermudah dalam memberikan informasi seputar RS. Mardi Waluyo Metro  kepada masyarakat”.  Tujuan dari penelitian yang dilakukan penulis dalam permasalahan yaitu merancang sistem informasi website dinamis pada RS. Mardi Waluyo Metro.  Kegunaan dari penelitian yaitu sistem informasi website yang dibangun dapat menjadi media promosi rumah sakit, masyarakat dalam mendapatkan informasi lebih mudah.

     Metode yang dipakai dalam pengumpulan data yaitu Studi Lapangan yang terdiri Wawancara, Pengamatan, Dokumentasi, dan Studi Pustaka.  Metode yang dipakai untuk merancang sistem adalah: menganalisis sistem yang sedang berjalan, mendesain sistem baru, membuat sistem/pemrograman, dan yang terakhir pengujian sistem.  Dalam penggambaran perancangan web pengembangan aplikasi yang digunakan yaitu Aliran Informasi, Diagram Konteks, Data Flow Diagram (DFD), Flowchart, Aplikasi yang digunakan yaitu:  Adobe Dreamweaver, Database Management System (DBMS), Adobe Photoshop, XAMPP, Microsoft Office Visio, Database, perancangan masukkan, dan pembuatan program
Applying venn diagram to present bloom’s cognitive level of students of a physics learning about light refraction using developed independent lab work module and PhET simulation “bending light”
Authors: Astuti Nurul H. , Sudjito Debora Natalia , Noviandini Diane
Published: July 2022

Evaluation shows the effectiveness of teaching and learning of a class. Mostly teachers provide evaluation in low cognitive level so students are able to achieve the minimum passing grade. Whereas a good evaluation should use Bloom’s Taxonomy as a basis for classifying student’s cognitive level. It leads teacher to provide a learning that facilitates student’s achievement of high cognitive level, including using independent lab work module. Teachers also typically provide a global report evaluation, i.e. providing the final score only, without presenting the distribution of students’ cognitive level. For this purpose, Venn Diagram is used to show the distribution of students’ cognitive level based on Bloom Taxonomy. This research aimed to present the distribution of students’ Bloom cognitive level using Venn Diagram and to investigate whether the development of independent lab work module about light refraction using PhET simulation “Bending Light“ can make students achieve the cognitive levels of knowing, understanding, applying, and analyzing. The obtained data was analyzed using qualitative descriptive method. The respondents were 17 freshmen of Physics Education and Physics Students of UKSW Batch 2016. The post-test showed that all students achieved higher cognitive levels. Thus, the developed independent lab work module was able to improve students’ cognitive level. Venn Diagram could also simplify the presentation of the distribution of students’ Bloom cognitive level for teachers.