bluuebunny/crossref_metadata_2025 huggingface dataset:
The Linear-Logistic Model: A Novel Paradigm for Estimating Dietary Amino Acid Requirements
Authors: Ramirez-Camba Christian D. , Levesque Crystal L.
Published: May 2023

This study aimed to determine whether current methods for estimating AA requirements for animal health and welfare are sufficient. An exploratory data analysis (EDA) was conducted, which involved a review of assumptions underlying AA requirements research, a data mining approach to identify animal responses to dietary AA levels exceeding those for maximum protein retention, and a literature review to assess the physiological relevance of the linear-logistic model developed through the data mining approach. The results showed that AA dietary levels above those for maximum growth resulted in improvements in key physiological responses, and the linear-logistic model depicted the AA level at which growth and protein retention rates were maximized, along with key metabolic functions related to milk yield, litter size, immune response, intestinal permeability, and plasma AA concentrations. The results suggest that current methods based solely on growth and protein retention measurements are insufficient for optimizing key physiological responses associated with health, survival, and reproduction. The linear-logistic model could be used to estimate AA doses that optimize these responses and, potentially, survival rates.
Clinical Outcome of Cefiderocol for Infections with Carbapenem-Resistant Organisms
Authors: Sajib Monirul I. , Monteforte Melinda , Go Roderick
Published: May 2023

Cefiderocol is a novel cephalosporin recently approved by the FDA to aid clinicians in the fight against multidrug-resistant (including carbapenem-resistant) gram-negative organisms. The primary objective of this study is to evaluate the 14- and 28-day mortality associated with cefiderocol. We performed a retrospective chart review of all adult patients admitted at Stony Brook University Hospital between October 2020 and December 2021 and received cefiderocol for at least 3 days. Patients were excluded if they received more than one course of cefiderocol therapy or remained hospitalized at the time of this study. A total of 22 patients met the inclusion criteria. The all-cause mortality on day 28 for all patients was 13.6%, whereas this rate for patients with BSI was 0%, with cUTI was 0% and with LRTI was 16.7%. The all-cause mortality on day 28 for patients who received the dual antibiotics (in conjunction with cefiderocol) was 0%, compared to 25% for patients who only received cefiderocol (p = 0.25). We noted treatment failure in two patients (9.1%). Our findings suggest that cefiderocol could possibly be associated with lower all-cause mortality than previously thought. In our study, we did not find any significant difference between cefiderocol’s use in combination with another antibacterial agent and its use as a monotherapy.
Detection of Migrating and Non-Migrating Atmospheric Tides Derived from ERA5 Temperature Meteorological Analyses
Authors: Keckhut Philippe , Lefebvre Thomas , Hauchecorne Alain , Meftah Mustapha , Khaykin Sergey
Published: May 2023

To better extract the tides represented in the European meteorological analysis ERA5, an analysis of the histograms of the diurnal and semi-diurnal modes as a function of longitudes was performed. This analysis revealed that modes with different characteristics appeared regionally along a single longitude. Retrieved migrating tides were compared with a tidal model showing global agreement below 60 km and twice the amplitude in meteorological analyses at mid-latitude. Non-migrating tidal modes have been identified along the tropical band. They logically appear above the convective zones, probably due to water vapor excess. Their characteristics are different from migrating components. This preliminary study has shown that it is necessary to develop additional observations allowing for more frequent sampling to retrieve migrating and non-migrating tides that can only be achieved with satellite constellations from space.
Brightness Temperature Characteristics of Short-Duration Heavy Rainfall in the Chengdu–Chongqing Railway Region in China
Authors: Liu Xinchao , Chen Yongren , Guo Jie , Song Wenwen , Dan Jia
Published: May 2023

In this study, we analyzed the brightness temperature characteristics of short-duration heavy rainfall (SDHR) along the Chengdu–Chongqing Railway (CCR), an important corridor of economic and transportation activity in southwest China. Our findings could prove useful in the monitoring and advance warning of SDHR events: (1) SDHR predominantly occurred from July to August, with a peak frequency in July in the CCR area. In terms of diurnal variation, SDHR was mainly observed at night, particularly between 22:00–05:00 and 06:00–09:00 (local time), with a peak at 01:00; (2) The relationship between SDHR and equivalent blackbody temperature (TBB) further showed that the occurrence of SDHR was accompanied by TBB decreasing to its minimum value, after which it increased, and SDHR ceased. In cases where TBB approached its minimum value after 1 h but continued to decrease slightly, SDHR continued. When SDHR occurred, the majority of the TBB values were recorded in the range 190–230 K; within this range, values between 190 and 200 K were most frequently recorded. In general, lower TBB values are associated with more intense SDHR. Based on this finding, we used linear regression to establish an estimating equation for SDHR.
Nexus between Social Vulnerability and Resilience to Agricultural Drought amongst South African Smallholder Livestock Households
Authors: Bahta Yonas T. , Lombard Willem A.
Published: May 2023

Livestock farmers in Sub-Saharan Africa rely on rain-fed agriculture, which exposes them to the risks of agricultural drought. Agricultural drought has become a significant threat to the extreme mortality of livestock, thus negatively impacting social vulnerability and household resilience to agricultural drought and extreme events. Researchers rarely empirically assess the connection between vulnerability and resilience, which are highly related concepts. By measuring and connecting vulnerability and resilience concepts closely related to disasters such as agricultural drought, this article makes a contribution to the body of disaster literature. The study aimed to empirically examine the relationship between smallholder livestock farming households’ social vulnerability and their resilience to agricultural drought. A survey of 217 smallholder livestock farmers was conducted. The Social Vulnerability Index (SVI), the Agricultural Drought Resilience Index (ADRI), and Pearson’s correlation coefficient were used for data analysis. A correlation was identified between resilience to agricultural drought and social vulnerability, indicating that smallholder livestock farmers are more susceptible to harm and lack the means to rebound effectively. Unsurprisingly, the majority of resource-poor smallholder livestock farmers (79%) lack safety nets during agricultural droughts. They are less resilient and more vulnerable households, leading them to social vulnerability. This study provides input/guidance to identify farming households with high social vulnerability and less resilience to threats and their capabilities of recouping and adopting after experiencing an agricultural drought. Additionally, looking at household resilience and social vulnerability to agricultural droughts could provide a way to pinpoint at-risk areas, assisting emergency planners in directing resources and intervention programs to those areas where assistance is most likely to be needed during disasters such as agricultural droughts. This implies that thorough policy intervention programs need to be tailored toward reducing damage or finding the path to recovery.
Remote Polar Boundary Layer Wind Profiling Using an All-Fiber Pulsed Coherent Doppler Lidar at Zhongshan Station, Antarctica
Authors: Li Hui , Wang Zhangjun , Zhuang Quanfeng , Wang Rui , Huang Wentao , Chen Chao , Li Xianxin , Wang Xiufen , Xue Boyang , Yu Yang , Pan Xin
Published: May 2023

A compact all-fiber pulsed coherent Doppler lidar (PCDL) for boundary layer wind measurement was developed by the Institute of Oceanographic Instrumentation, Qilu University of Technology (Shandong Academy of Sciences). It has been deployed at Zhongshan Station (69.4° S, 76.4° E) during the 2020 austral summer season by the 36th Chinese National Antarctic Research Expedition (CHINARE) and started routine observation in January 2020. This system, based on the 1550 nm all-fiber components, employs a 100 mm telescope with a long focal length of 632.6 mm to emit and collect laser pulses. It provides the ability to measure vertically resolved wind fields with a spatial resolution of 30 m and a temporal resolution of 1 min; the maximum detection range is up to 1.5 km in Antarctica. Wind speed and direction inversion methods were introduced subsequently. Preliminary measurement results of wind profiles indicate that this Doppler lidar can be operated successfully in Antarctica. The synchronous observations between the lidar, anemometer, and radiosondes at Zhongshan station are presented and have good consistency with each other. The comparison results between the lidar and anemometer indicate a root mean square deviation (RMSD) of 0.98 m s−1 and 10.55° for wind speed and direction, respectively. The lidar continuous observations of wind profiles provide an opportunity to study the spatiotemporal variation of Antarctic wind with high resolutions, which is useful for further understanding of the atmosphere in Antarctic regions.
Augmented Reality Surgical Navigation System Integrated with Deep Learning
Authors: Chiou Shin-Yan , Liu Li-Sheng , Lee Chia-Wei , Kim Dong-Hyun , Al-masni Mohammed A. , Liu Hao-Li , Wei Kuo-Chen , Yan Jiun-Lin , Chen Pin-Yuan
Published: May 2023

Most current surgical navigation methods rely on optical navigators with images displayed on an external screen. However, minimizing distractions during surgery is critical and the spatial information displayed in this arrangement is non-intuitive. Previous studies have proposed combining optical navigation systems with augmented reality (AR) to provide surgeons with intuitive imaging during surgery, through the use of planar and three-dimensional imagery. However, these studies have mainly focused on visual aids and have paid relatively little attention to real surgical guidance aids. Moreover, the use of augmented reality reduces system stability and accuracy, and optical navigation systems are costly. Therefore, this paper proposed an augmented reality surgical navigation system based on image positioning that achieves the desired system advantages with low cost, high stability, and high accuracy. This system also provides intuitive guidance for the surgical target point, entry point, and trajectory. Once the surgeon uses the navigation stick to indicate the position of the surgical entry point, the connection between the surgical target and the surgical entry point is immediately displayed on the AR device (tablet or HoloLens glasses), and a dynamic auxiliary line is shown to assist with incision angle and depth. Clinical trials were conducted for EVD (extra-ventricular drainage) surgery, and surgeons confirmed the system’s overall benefit. A “virtual object automatic scanning” method is proposed to achieve a high accuracy of 1 ± 0.1 mm for the AR-based system. Furthermore, a deep learning-based U-Net segmentation network is incorporated to enable automatic identification of the hydrocephalus location by the system. The system achieves improved recognition accuracy, sensitivity, and specificity of 99.93%, 93.85%, and 95.73%, respectively, representing a significant improvement from previous studies.
Cocaine Destroys Gray Matter Brain Cells and Accelerates Brain Aging
Authors: Beheshti Iman
Published: May 2023

Introduction: Cocaine use disorder (CUD) is a substance use disorder characterized by a strong desire to obtain, consume, and misuse cocaine. Little is known about how cocaine affects the structure of the brain. In this study, we first investigated the anatomical brain changes in individuals with CUD compared to their matched healthy controls, and then explored whether these anatomical brain abnormalities contribute to considerably accelerated brain aging among this population. Methods: At the first stage, we used anatomical magnetic resonance imaging (MRI) data, voxel-based morphometry (VBM), and deformation-based morphometry techniques to uncover the morphological and macroscopic anatomical brain changes in 74 CUD patients compared to 62 age- and sex-matched healthy controls (HCs) obtained from the SUDMEX CONN dataset, the Mexican MRI dataset of patients with CUD. Then, we computed brain-predicted age difference (i.e., brain-PAD: the brain-predicted age minus the actual age) in CUD and HC groups using a robust brain age estimation framework. Using a multiple regression analysis, we also investigated the regional gray matter (GM) and white matter (WM) changes associated with the brain-PAD. Results: Using a whole-brain VBM analysis, we observed widespread gray matter atrophy in CUD patients located in the temporal lobe, frontal lobe, insula, middle frontal gyrus, superior frontal gyrus, rectal gyrus, and limbic lobe regions compared to the HCs. In contrast, we did not observe any swelling in the GM, changes in the WM, or local brain tissue atrophy or expansion between the CUD and HC groups. Furthermore, we found a significantly higher brain-PAD in CUD patients compared to matched HCs (mean difference = 2.62 years, Cohen’s d = 0.54; t-test = 3.16, p = 0.002). The regression analysis showed significant negative changes in GM volume associated with brain-PAD in the CUD group, particularly in the limbic lobe, subcallosal gyrus, cingulate gyrus, and anterior cingulate regions. Discussion: The results of our investigation reveal that chronic cocaine use is linked to significant changes in gray matter, which hasten the process of structural brain aging in individuals who use the drug. These findings offer valuable insights into the impact of cocaine on the composition of the brain.
Highly Sensitive Detection of Urea Using Si Electrolyte-Gated Transistor with Low Power Consumption
Authors: Choi Wonyeong , Jin Bo , Shin Seonghwan , Do Jeonghyeon , Son Jongmin , Kim Kihyun , Lee Jeong-Soo
Published: May 2023

We experimentally demonstrate Si-based electrolyte-gated transistors (EGTs) for detecting urea. The top-down-fabricated device exhibited excellent intrinsic characteristics, including a low subthreshold swing (SS) (~80 mV/dec) and a high on/off current ratio (~107). The sensitivity, which varied depending on the operation regime, was analyzed with the urea concentrations ranging from 0.1 to 316 mM. The current-related response could be enhanced by reducing the SS of the devices, whereas the voltage-related response remained relatively constant. The urea sensitivity in the subthreshold regime was as high as 1.9 dec/pUrea, four times higher than the reported value. The extracted power consumption of 0.3 nW was extremely low compared to other FET-type sensors.
Application of Original Therapy for Stimulation of Oral Areas Innervated by the Trigeminal Nerve in a Child with Beckwith–Wiedemann Syndrome
Authors: Pawlukowska Wioletta , Patalan Michał , Bagińska Ewelina , Giżewska Maria , Masztalewicz Marta
Published: May 2023

About 90% of children diagnosed with classic BWS have macroglossia, and 40% of them are submitted to surgical tongue reduction. The purpose of our article is to present a case study of a 5-month-old child with BWS who was treated with an original therapy for stimulation of oral areas innervated by the trigeminal nerve. The therapy included stimulation of the upper and lower lip and muscles of the floor of the mouth. The treatment was provided by a therapist once a week. In addition, the child was stimulated every day at home by his mother. After 3 months, a significant improvement in oral alignment and function was achieved. Preliminary observations of therapy application for stimulation regions innervated by the trigeminal nerve in children with Beckwith–Wiedemann syndrome seem promising. The original therapy for stimulation of oral areas innervated by the trigeminal nerve is a good alternative to existing methods of surgical tongue reduction in children with BWS and macroglossia.
Brain Activities Show There Is Nothing Like a Real Friend in Contrast to Influencers and Other Celebrities
Authors: Walla Peter , Külzer Dimitrios , Leeb Annika , Moidl Lena , Kalt Stefan
Published: May 2023

Especially for young people, influencers and other celebrities followed on social media evoke affective closeness that in their young minds seems real even though it is fake. Such fake friendships are potentially problematic because of their felt reality on the consumer side while lacking any inversely felt true closeness. The question arises if the unilateral friendship of a social media user is equal or at least similar to real reciprocal friendship. Instead of asking social media users for explicit responses (conscious deliberation), the present exploratory study aimed to answer this question with the help of brain imaging technology. Thirty young participants were first invited to provide individual lists including (i) twenty names of their most followed and loved influencers or other celebrities (fake friend names), (ii) twenty names of loved real friends and relatives (real friend names) as well as (iii) twenty names they do not feel any closeness to (no friend names). They then came to the Freud CanBeLab (Cognitive and Affective Neuroscience and Behavior Lab) where they were shown their selected names in a random sequence (two rounds), while their brain activities were recorded via electroencephalography (EEG) and later calculated into event-related potentials (ERPs). We found short (ca. 100 ms) left frontal brain activity starting at around 250 ms post-stimulus to process real friend and no friend names similarly, while both ERPs differed from those elicited by fake friend names. This is followed by a longer effect (ca. 400 ms), where left and right frontal and temporoparietal ERPs also differed between fake and real friend names, but at this later processing stage, no friend names elicited similar brain activities to fake friend names in those regions. In general, real friend names elicited the most negative going brain potentials (interpreted as highest brain activation levels). These exploratory findings represent objective empirical evidence that the human brain clearly distinguishes between influencers or other celebrities and close people out of real life even though subjective feelings of closeness and trust can be similar. In summary, brain imaging shows there is nothing like a real friend. The findings of this study might be seen as a starting point for future studies using ERPs to investigate social media impact and topics such as fake friendship.
Mirror Therapy in Patients with Somatoform Pain Disorders—A Pilot Study
Authors: Ruf Steffen Philipp , Hetterich Larissa , Mazurak Nazar , Rometsch Caroline , Jurjut Anna-Maria , Ott Stephan , Herrmann-Werner Anne , Zipfel Stephan , Stengel Andreas
Published: May 2023

Patients with chronic pain report reduced quality of life and high symptom burden while often responding insufficiently to treatment options. Mirror therapy has been proven to be effective in treating phantom limb pain and other conditions such as CRPS. This study was designed to investigate the efficacy of mirror therapy in patients with somatoform pain disorders on symptom severity and associated physiological parameters. Fifteen patients with persistent somatoform pain disorder (F45.40) or chronic pain disorder with somatic and psychological factors (F45.41) participated and received four weeks of tablet-based mirror therapy. Symptom severity was measured with established questionnaires, and their thermal detection, pain thresholds, and heart rate variability (HRV) were also assessed. After mirror therapy, pain intensity was reduced (z = −2.878, p = 0.004), and pain thresholds for cold stimuli were also diminished, i.e., the subjects became more sensitive to cold stimuli (z = −2.040, p = 0.041). In addition, a reduction of absolute power in the low-frequency band of HRV (t(13) = 2.536, p = 0.025) was detected. These findings indicate that this intervention may reduce pain intensity and modulate associated physiological parameters. As these results are limited by several factors, e.g., a small sample size and no control group, they should be validated in further studies investigating this novel intervention in these patients.
The Role of Sex in the Effect of Vocal Attractiveness on Ultimatum Game Decisions
Authors: Shang Junchen , Liu Chang Hong
Published: May 2023

The present research investigated the role of sex in the effect of vocal attractiveness on fairness judgment in a two-person Ultimatum Game. Each participant in the game decided whether to accept offers from a proposer who was either associated with an attractive or unattractive voice. The results showed that while participants were more likely to accept fair offers, they would also accept some unfair offers that were associated with an attractive voice. This effect of vocal attractiveness was more clearly shown by female participants, although all male and female participants took longer to make a decision when an attractive voice was associated with an offer, regardless of whether the voice was from the same sex or the opposite sex. Overall, the results inform the role of sex in the effect of vocal attractiveness and further confirm the beauty premium effect on economic bargaining, where people with an attractive voice would benefit.
Effects of the Interactive Features of Virtual Partner on Individual Exercise Level and Exercise Perception
Authors: Wang Yinghao , Zhang Mengsi , Wu Jianfeng , Zhang Haonan , Yang Hongchun , Guo Songyang , Lin Zishuo , Lu Chunfu
Published: May 2023

Background: We designed an exercise system in which the user is accompanied by a virtual partner (VP) and tested bodyweight squat performance with different interactive VP features to explore the comprehensive impact of these VP features on the individual’s exercise level (EL) and exercise perception. Methods: This experiment used three interactive features of VP, including body movement (BM), eye gaze (EG), and sports performance (SP), as independent variables, and the exercise level (EL), subjective exercise enjoyment, attitude toward the team formed with the VP, and local muscle fatigue degree of the exerciser as observational indicators. We designed a 2 (with or without VP’s BM) × 2 (with or without VP’s EG) × 2 (with or without VP’s SP) within-participants factorial experiment. A total of 40 college students were invited to complete 320 groups of experiments. Results: (1) Regarding EL, the main effects of BM and SP were significant (p < 0.001). The pairwise interaction effects of the three independent variables on EL were all significant (p < 0.05). (2) Regarding exercise perception, the main effects of BM (p < 0.001) and EG (p < 0.001) on subjective exercise enjoyment were significant. The main effect of BM on the attitude toward the sports team formed with the VP was significant (p < 0.001). The interaction effect of BM and SP on the attitude toward the sports team formed with the VP was significant (p < 0.001). (3) Regarding the degree of local muscle fatigue, the main effects of BM, EG, and SP and their interaction effects were not significant (p > 0.05). Conclusion: BM and EG from the VP elevate EL and exercise perception during squat exercises, while the VP with SP inhibited the EL and harmed exercise perception. The conclusions of this study can provide references to guide the interactive design of VP-accompanied exercise systems.
Factors and Areas of PgMO Supporting the Success of the Program Management in the Construction Sector
Authors: Trzeciak Mateusz
Published: May 2023

In recent years, the construction sector has been increasingly inclined toward using systematic program management approaches. Despite acknowledging the crucial impact of PgMO on program management success, the existing literature lacks sufficient research on the areas where this office can provide support for success in the construction sector. This article aims to identify the critical success factors and PgMO areas that contribute to program success in the construction sector. To address the research questions and goals, standardized interviews were conducted with 49 PgMO members from 14 organizations implementing construction programs. Based on the literature and statistical analysis, ten critical success factors (CSFs) for construction programs were identified. However, the significance of these CSFs may vary depending on the context of the construction sector. Furthermore, statistical analysis revealed five areas where PgMO can support program success: maintaining program governance, program initiation, program planning and budgeting, stakeholder and relationship management, and requirements and knowledge management resulting from program implementation. Managers are advised to take action in all the identified areas of PgMO to increase the likelihood of achieving program success. They should also pay attention to weaker areas and strengthen them as part of best practices.
Quantitative Estimation of the Internal Spatio–Temporal Characteristics of Ancient Temple Heritage Space with Space Syntax Models: A Case Study of Daming Temple
Authors: Zhou Kai , Wu Wenting , Dai Xiaoling , Li Tianjie
Published: May 2023

Ancient temple heritage space is a subcategory of integrated spaces with profound religious architecture, culture, and landscape. The temporal and spatial characteristics, spatial layouts, and functionalities of ancient temples are gradually transformed during different periods in their development. However, quantitative topological estimation tools, e.g., space syntax and detailed digital spatial models, have seldom been adopted in related studies on ancient temples. Daming Temple is a typical representative of the revitalization of Buddhism monastic building heritage in China. This research studies the spaces of Daming Temple, Yangzhou City, in three different periods and explores its spatio–temporal characteristics based on two space syntax models, i.e., the angle segment analysis (ASA) model and the visibility map analysis (VGA) model. By multi-step quantitative estimation, changes in the mean depth (MD), mean connectivity, and intelligibility of the temple have been observed. The global spatial structure is thoroughly revealed, which indicates the changes in the ‘temple-residence-garden’ inter-relationship. It is indicated that dynamic spatio–temporal characteristics of the temple have been undergoing changes chronically. Some phenomena are found to be effective in offering reasonable explanations for these changes, i.e., the changes in relationships among spaces, visitors’ pathfinding difficulties, and spatial design techniques. It also found that there are certain correlations between temporal–spatial changes and spatial conservation strategies for building heritages. The case study can provide some valuable references for the conservation, reactivation, and redesign of related historical and cultural building heritage in East Asia.
Research on Carbon Emission of Prefabricated Structure in China
Authors: Huang Yuan , Wang Anqi
Published: May 2023

The comparison of carbon emissions between prefabricated and traditional cast-in-place construction methods in actual example buildings has yielded inconsistent results due to the difficulty in accounting for design parameter uncertainty. Additionally, the carbon-reduction capacity of prefabricated structures remains a topic of debate. This paper investigates the carbon emission reduction capacity of prefabricated concrete frame structures compared to traditional cast-in-place structures, with a focus on addressing design parameter uncertainty. A quantitative model of carbon emissions is established using the subproject quota method and PKPM-PC software. The study evaluates the impact of design parameters, such as slab span and seismic requirements, and calculation parameters, such as carbon emission factor and transport distance, on carbon emissions. The results indicate that prefabricated structures with a higher assembly rate exhibit a stronger emission reduction capacity, mainly due to lower demands for labor and mechanical energy consumption. The study also highlights that prefabricated structures with smaller slab spans and higher seismic requirements have lower carbon emission reduction capacities and can produce greater carbon emissions than cast-in-place structures. Furthermore, the appropriate carbon emission factor for the material used in prefabricated structures is crucial for achieving reliable carbon reduction rates. Finally, the study emphasizes the importance of considering transport as a small but significant factor in structural comparison, as changes in transport distance can significantly impact results.
Full-Scale Experimental Study on Flexural Performance of the New Precast UHPC Diaphragm Slab in Utility Tunnels
Authors: Cheng Quan , Li Zhengwei , Deng Shaowei , Jiang Haibo , Tian Yueqiang , Geng Jiayue
Published: May 2023

In this paper, a bending test of a precast ultra-high-performance concrete (UHPC) diaphragm slab was carried out. The test revealed that the flexural failure process of specimens under the action of a positive bending moment can be divided into three stages: the elastic, crack-propagation, and yield stages. The first stiffness reduction of the structure was caused by cracks at the bottom of the diaphragm slab, while the second stiffness drop resulted from the yielding of the bottom longitudinal rebars. During the loading process, the ultimate bearing capacity was 3.75 times higher than the design load value (150 kN vs. 40 kN). Additionally, a nonlinear finite element model was established using Abaqus software validated by the test and exploiting parameter analysis. Based on this model, the initial crack stress of the actual slab was determined to be 5.12 MPa. Parameter analysis indicated that the shear strength of the diaphragm slab was stronger than the flexural strength, and the diaphragm slab’s bearing capacity could be improved by increasing the ratio of bottom longitudinal reinforcement. This research confirmed that the new UHPC diaphragm slab used in Guangzhou Smart City is safe, and it also helped the design of similar UHPC slabs for utility tunnels.
Investigating the Viability of Recycling Rice Husk Ash and Plastic Bag Waste to Enhance Durability of Lightweight Concrete
Authors: El-Attar Mohamed M. , Ibrahim Hatem H. A. , Darwish Shereen F. A.
Published: May 2023

The disposal of waste plastic bags (WPB) represents an environmental challenge. Recycling (WPB) in the concrete industry would represent a huge environmental advantage if proven effective and economic. This study aims to investigate the viability of recycling rice husk ash and plastic bag waste to enhance the durability of lightweight concrete (LWC). Rice husk ash (RHA) is used as a cement replacement to reduce the health and environmental hazards originating from the cement industry. The mutual influence of using WPB and RHA on the mechanical properties and durability of LWC is investigated in this study. The effect of various WPB contents (10, 20 and 30%) as natural sand substitution with RHA of (5, 10 and 15%) as partial cement replacement on the flow-ability, self- weight, compressive and tensile strengths, water permeability, chloride resistance, and fire resistance was examined and reported. The results of this study consolidated the idea of recycling WPB in the construction field. In summary, the optimal content of WPB is 10% by volume of fine aggregate and 10% of RHA by weight of cement.
Pythagorean Fuzzy AHP Based Dynamic Subcontractor Management Framework
Authors: Başaran Yunus , Aladağ Hande , Işık Zeynep
Published: May 2023

In construction projects, a significant part of construction work is done by subcontractors (SCs). Therefore, their management by main contractors (MCs) becomes an important issue as the density of SCs is created at the construction sites. In recent years, more focus on SC evaluation and selection in bidding process has been on the agenda whereas the subject of SC performance appraisal on-site during the project execution phase has been untended in the literature. Thus, this study aims to focus on the measurement and evaluation of the performance of SCs in the project execution phase, and to provide a tentative performance-based dynamic management framework that MCs will use in the management of SCs in order to take proactive measures. In line with the aim, a total number of 23 performance measurement criteria (PMC) under 7 main groups were determined as a result of a comprehensive literature review and expert evaluations. Knowing that not every criterion will have the same effect in performance measurement, pairwise comparisons of the criteria were made using the Pythagorean Fuzzy Analytic Hierarchy Process (PFAHP) method and their importance weights were determined. The PFAHP method was obtained by integrating the Pythagorean fuzzy set into the AHP method and chosen with the aim of improving the fuzzy AHP method and obtaining more consistent results by eliminating the uncertainty since Pythagorean fuzzy sets is more capable than fuzzy sets at expressing and handling uncertainty in uncertain environments. Lastly, a framework for SC performance measurement and evaluation on project execution phase is presented. It is believed that the presented framework will allow for a proactive management style that will enable effective decisions to be made while the project is ongoing, and a dynamic way of working instead of static and conventional work.
Benefit of Early Ruxolitinib Initiation Regardless of Fibrosis Grade in Patients with Primary Myelofibrosis: A Post Hoc Analysis of the Single-Arm Phase 3b JUMP Study
Authors: Palandri Francesca , Al-Ali Haifa Kathrin , Guglielmelli Paola , Zuurman Mike W. , Sarkar Rajendra , Gupta Vikas
Published: May 2023

Bone marrow fibrosis (BMF) is an adverse prognostic factor for myelofibrosis (MF). The single-arm, open-label, phase 3b JUMP trial (NCT01493414) assessed the safety and efficacy of the JAK1/JAK2 inhibitor ruxolitinib in patients with symptomatic MF. This post hoc analysis investigated the impact of BMF grade on response and outcomes in patients with primary MF (PMF) from the JUMP study. BMF was assessed by biopsy and graded from 0 to 3; grades 0–1 were considered low-grade fibrosis (LGF) and grades 2–3 were considered high-grade fibrosis (HGF). Patients with LGF (n = 268) had lower rates of cytopenias at baseline but showed comparable disease burden vs. patients with HGF (n = 852). The proportion of patients achieving a spleen response was greater in the LGF group vs. the HGF group at Week 24 and at any time during the study, while overall survival estimates were improved in patients with LGF vs. patients with HGF. Early initiation of ruxolitinib therapy (within 2 years of diagnosis) was associated with increased response rates in all patients. These results highlight the efficacy of ruxolitinib in symptomatic patients with PMF, with the greatest clinical improvements observed in patients with LGF and in patients who received early treatment.
The Contribution of Bullying Involvement and Alexithymia to Somatic Complaints in Preadolescents
Authors: Levantini Valentina , Camodeca Marina , Iannello Nicolò Maria
Published: May 2023

Somatic complaints during preadolescence are connected to individual and contextual factors, and extant research highlights the relevance of alexithymia and bullying involvement. In this cross-sectional study, we explored the joint and unique influence of bullying involvement—as perpetrators, victims, or outsiders—and alexithymia on somatic complaints in a sample of 179 Italian middle-school students (aged 11–15). Findings revealed an indirect association between bullying perpetration and victimization complaints through alexithymia. We also found a significant direct association between victimization and somatic complaints. No significant association between outsider behavior and somatization was found. Our results revealed that bullying perpetration and victimization could increase youths’ risk for somatic complaints and clarify one of the processes underlying this association. The current findings further emphasize the relevance of emotional awareness for youths’ well-being and propose that implementing social–emotional skills might prevent some of the adverse consequences of being involved in bullying episodes.
Maternal Infection and Preterm Birth: From Molecular Basis to Clinical Implications
Authors: Daskalakis George , Psarris Alexandros , Koutras Antonios , Fasoulakis Zacharias , Prokopakis Ioannis , Varthaliti Antonia , Karasmani Christina , Ntounis Thomas , Domali Ekaterini , Theodora Marianna , Antsaklis Panos , Pappa Kalliopi I. , Papapanagiotou Angeliki
Published: May 2023

As the leading cause of neonatal morbidity and mortality, preterm birth is recognized as a major public health concern around the world. The purpose of this review is to analyze the connection between infections and premature birth. Spontaneous preterm birth is commonly associated with intrauterine infection/inflammation. The overproduction of prostaglandins caused by the inflammation associated with an infection could lead to uterine contractions, contributing to preterm delivery. Many pathogens, particularly Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas vaginalis, Gardnerella vaginalis, Ureaplasma urealyticum, Mycoplasma hominis, Actinomyces, Candida spp., and Streptococcus spp. have been related with premature delivery, chorioamnionitis, and sepsis of the neonate. Further research regarding the prevention of preterm delivery is required in order to develop effective preventive methods with the aim of reducing neonatal morbidity.
The Advantages of Double Catalytic Layers for Carbon Nanotube Growth at Low Temperatures (<400 °C) in 3D Stacking and Power Applications
Authors: Lin Hong-Yi , Basu Nilabh , Lee Min-Hung , Chen Sheng-Chi , Liao Ming-Han
Published: May 2023

A double catalytic layer scheme is proposed and investigated for the low temperature growth of carbon nanotubes (CNTs) over Co (Cobalt), Al (Aluminum), and Ti (Titanium) catalysts on a silicon substrate. In this work, we demonstrate the growth of CNTs by a thermal chemical vapor deposition (TCVD) process at both 350 °C and 400 °C. Based on scanning electron microscopy (SEM) and Raman spectroscopy analyses, the good quality of the CNTs is demonstrated. This study contributes to the on-going research on integrating semiconductors into packaging and power-related applications, as demonstrated with the low resistance (~128 Ω) and high thermal conductivity (~29.8 Wm−1 K−1) of our developed CNTs.
Electronic and Electrical Properties of Island-Type Hybrid Structures Based on Bi-Layer Graphene and Chiral Nanotubes: Predictive Analysis by Quantum Simulation Methods
Authors: Slepchenkov Michael M. , Barkov Pavel V. , Glukhova Olga E.
Published: May 2023

Hybrid structures based on graphene and carbon nanotubes (CNTs) are one of the most relevant modern nanomaterials for applications in various fields, including electronics. The variety of topological architectures of graphene/CNT hybrids requires a preliminary study of their physical properties by in silico methods. This paper is devoted to the study of the electronic and electrical properties of graphene/CNT hybrid 2D structures with an island topology using the self-consistent charge density functional-based tight-binding (SCC-DFTB) formalism and the Landauer–Buttiker formalism. The island-type topology is understood as the atomic configuration of a graphene/CNT hybrid film, in which the structural fragments of graphene and nanotubes form “islands” (regions of the atomic structure) with an increased density of carbon atoms. The island-type graphene/CNT hybrid structures are formed by AB-stacked bilayer graphene and (6,3)/(12,8) chiral single-walled carbon nanotubes (SWCNT). The bilayer graphene is located above the nanotube perpendicular to its axis. Based on the binding energy calculations, it is found that the atomistic models of the studied graphene/SWCNT hybrid structures are thermodynamically stable. The peculiarities of the band structure of graphene/SWCNT (6,3) and graphene/SWCNT (12,8) hybrid structures are analyzed. It is shown that the electronic properties of graphene/SWCNT hybrid structures are sensitive to the orientation and size of the graphene layers with respect to the nanotube surface. It is found that an energy gap of ~0.1 eV opens in the band structure of only the graphene/SWCNT (6,3) hybrid structure, in which the graphene layers of the same length are arranged horizontally above the nanotube surface. We revealed the electrical conductivity anisotropy for all considered atomistic models of the graphene/SWCNT (12,8) hybrid structure when bilayer graphene sheets with different sizes along the zigzag and armchair directions are located at an angle with respect to the nanotube surface. The obtained knowledge is important to evaluate the prospects for the potential application of the considered atomic configurations of graphene/SWCNT hybrid structures with island-type topology as connecting conductors and electrodes in electronic devices.
Optical Gain of a Spherical InAs Quantum Dot under the Effects of the Intense Laser and Magnetic Fields
Authors: Aghoutane Noreddine , Pérez Laura M. , Laroze David , Díaz Pablo , Rivas Miguel , El-Yadri Mohamed , Feddi El Mustapha
Published: May 2023

In quantum dots, where confinement is strong, interactions between charge carriers play an essential role in the performance of semiconductor materials for optical gain. Therefore, understanding this phenomenon is critical for achieving new devices with enhanced features. In this context, the current study examines the optical properties of an exciton confined in a spherical InAs quantum dot under the influence of magnetic and intense laser fields. We investigate the oscillator strength, exciton lifetime, and optical gain, considering the effects of both external fields. We also pay particular attention to the influence of quantum dot size on the results. Our calculations show that the two external fields have opposite effects on our findings. Specifically, the applied magnetic field increases the oscillator strength while the intense laser reduces it. In addition, the optical gain peaks are redshifted under the application of the intense laser, whereas the magnetic field causes a blueshift of the peak threshold. We also find that both external perturbations significantly influence the exciton lifetime. Our study considers the outcomes of both the exciton’s ground (1s) and first excited (1p) states. The theoretical results obtained in this study have promising implications for optoelectronic devices in the ∼3–4 μm wavelength range only through the control of quantum dot sizes and external perturbations.
Robotic Hysterectomy with Ureter Identification and Uterine Artery Ligation for Benign Gynecological Conditions: An Early-Year Single-Center Experience
Authors: Lee Yi-Liang , Chiang Kai-Jo , Lin Chi-Kung , Chao Tai-Kuang , Yu Mu-Hsien , Liu Yung-Liang , Wang Yu-Chi
Published: May 2023

The use and application of robotic systems with a high-definition, three-dimensional vision system and advanced EndoWrist technology have become widespread. We sought to share our clinical experience with ureter identification and preventive uterine artery ligation in robotic hysterectomy. The records of patients undergoing robotic hysterectomy between May 2014 and December 2015, including patient preoperative characteristics, operative time, and postoperative outcomes, were analyzed. We evaluated the feasibility and safety of using early ureteral identification and preventive uterine artery ligation in robotic hysterectomy in patients with benign gynecological conditions. Overall, 49 patients diagnosed with benign gynecological conditions were evaluated. The mean age of the patients and mean uterine weight were 46.2 ± 5.3 years and 348.7 ± 311.8 g, respectively. Robotic hysterectomy achieved satisfactory results, including a short postoperative hospital stay (2.7 ± 0.8 days), low conversion rate (n = 0), and low complication rate (n = 1; 2%). The average estimated blood loss was 109 ± 107.2 mL. Our results suggest that robotic hysterectomy using early ureteral identification and preventive uterine artery ligation is feasible and safe in patients with benign gynecological conditions.
The Role of Multimodality Imaging in the Diagnosis and Follow-Up of Malignant Primary Cardiac Tumors: Myxofibrosarcoma—A Case Report and Literature Review
Authors: Șerban Adela , Dădârlat-Pop Alexandra , Tomoaia Raluca , Trifan Cătălin , Molnar Adrian , Manole Simona , Achim Alexandru , Suceveanu Mihai
Published: May 2023

Cardiac tumors are a very rare but heterogenous group of diseases that may reveal themselves through a variety of nonspecific cardiac symptoms that may pose a challenge to the diagnostic process. Myxofibrosarcoma is a particularly rare type of cardiac tumor that carries a poor prognosis, thus making accurate and timely diagnosis essential. A 61-year-old woman presented with fatigue and shortness of breath during mild exercise, symptoms that have progressively worsened during the previous year. Multimodality imaging consisting of transthoracic and transesophageal echocardiography (TTE and TEE), cardiac magnetic resonance (CMR), cardiac computer tomography (CCT), and fluorodeoxyglucose positron emission computer tomography (18F-FDG PET-CT) was used for the diagnosis and postoperative follow-up of a myxofibrosarcoma.
Assuring Safe and Efficient Operation of UAV Using Explainable Machine Learning
Authors: Alharbi Abdulrahman , Petrunin Ivan , Panagiotakopoulos Dimitrios
Published: May 2023

The accurate estimation of airspace capacity in unmanned traffic management (UTM) operations is critical for a safe, efficient, and equitable allocation of airspace system resources. While conventional approaches for assessing airspace complexity certainly exist, these methods fail to capture true airspace capacity, since they fail to address several important variables (such as weather). Meanwhile, existing AI-based decision-support systems evince opacity and inexplicability, and this restricts their practical application. With these challenges in mind, the authors propose a tailored solution to the needs of demand and capacity management (DCM) services. This solution, by deploying a synthesized fuzzy rule-based model and deep learning will address the trade-off between explicability and performance. In doing so, it will generate an intelligent system that will be explicable and reasonably comprehensible. The results show that this advisory system will be able to indicate the most appropriate regions for unmanned aerial vehicle (UAVs) operation, and it will also increase UTM airspace availability by more than 23%. Moreover, the proposed system demonstrates a maximum capacity gain of 65% and a minimum safety gain of 35%, while possessing an explainability attribute of 70%. This will assist UTM authorities through more effective airspace capacity estimation and the formulation of new operational regulations and performance requirements.