bluuebunny/crossref_metadata_2025 huggingface dataset:
Praktyczne konsekwencje interpretacji natury niepewności
Authors: Dziubińska Agnieszka
Published: July 2024

Współczesne otoczenie narzuca organizacjom złożoną presję, określaną wręcz mianem polikryzysu. Towarzyszące tym zjawiskom wysokie stany niepewności w wymiarze praktycznym postrzegane są jako zagrażające ciągłości organizacji, w sferze teorii skłaniają zaś do krytycznej refleksji nad obowiązującym paradygmatem zarządzania strategicznego. Aktualność i waga problemu stały się inspiracją do podjęcia badań własnych, których celem była identyfikacja podstaw skutecznego działania organizacji w warunkach niepewności. Natura analizowanego problemu badawczego skłoniła do przyjęcia interdyscyplinarnego podejścia, zasadzającego się na studiach literaturowych dotyczących interpretacji zjawiska niepewności. W rozważaniach wykorzystano w szczególności typologię uwzględniającą procesualne, behawioralne i strukturalne ujęcia kategorii niepewności. Niepewność jest utożsamiana z nieokreślonością odnoszoną do przyszłości. Brak możliwości wyznaczania prawdopodobnych rezultatów podejmowanych działań wymaga poszukiwania alternatywnych postaw w procesach decyzyjnych. Taką perspektywę otwiera propozycja interwencji systemowej, która wpisuje się w nurt badań nad strategią jako praktyką społeczną. Elementy interwencji podejmowanej w dynamicznym otoczeniu – krytyka granic, osądy i działania – wspiera literatura odnosząca się do różnych, wymienionych wyżej, teoretycznych typów niepewności. Zestawienie ze sobą wyników studiów literaturowych i stosowanych w praktyce wytycznych pozwala wskazać na komplementarny charakter badań nad naturą niepewności w różnych dyscyplinach naukowych. Najważniejszą zaletą uzyskanych wyników badań w ujęciu teoretycznym jest stworzenie spójnych ram koncepcyjnych, dzięki którym można formułować wnioski na różnym poziomie ogólności w odniesieniu do zagadnień związanych z działaniem organizacji w warunkach niepewności. Wykorzystanie założeń bliskich praktyce wyznacza też skuteczną drogę do zmniejszenia luki poznawczej między światem poszukiwań akademickich a obszarem gospodarczej aktywności decydentów.
Zrównoważona strategia wobec teorii instytucjonalnej przedsiębiorstwa
Authors: Szplit Andrzej , Szplit Marcin
Published: July 2024

Coraz większa turbulencja otoczenia sprawia, że klasyczne metody budowy strategii i zasad funkcjonowania przedsiębiorstw stają się mało przydatne. Dotyczy to nawet podstawowych założeń zarządzania relacjami, tak w ujęciu epistemologicznym, jak i metodologicznym. Z uwagi na obecne problemy społeczno-gospodarcze związane głównie z katastrofą klimatyczną szczególną rolę odgrywa presja na odpowiedni (zrównoważony – trwały) rozwój. Celem publikacji jest zbadanie możliwości budowy odpowiedzialnej strategii przedsiębiorstwa w ramach uwarunkowań społeczno-ekologicznych. W publikacji nawiązuje się do badań Rafała Krupskiego i jego koncepcji kreowania strategii z wymogami identyfikowania okazji i definiowania redundancji zasobów i kompetencji. Według Krupskiego zrównoważony wzrost jest pewną ideą zachowania się w otoczeniu, gdzie warunki niepewności występują powszechnie. Może to powodować, że optimum lokalne traktowane autonomicznie może być jednym z najgorszych rozwiązań z punktu widzenia optimum globalnego. Profesor Krupski zachęca, by problemy równowagi pomiędzy organizacją i jej otoczeniem stawały się przedmiotem dalszych badań naukowych, ponieważ mają podstawowe znaczenie dla teorii i praktyki zarządzania strategicznego. W nawiązaniu do tych postulatów autorzy opracowania uwzględniają w badaniach założenia teorii instytucjonalnej przedsiębiorstwa.
Green BPM jako koncepcja realizacji założeń ESG w sektorze finansowo-ubezpieczeniowym
Authors: Brajer-Marczak Renata , Kalinowski Tomasz Bartosz , Bitkowska Agnieszka
Published: July 2024

Zrównoważone zarządzanie procesowe (Green Business Process Management – Green BPM) uwzględnia aspekty środowiskowe w zarządzaniu procesami ze szczególnym uwzględnieniem konsekwencji środowiskowych na każdym etapie łańcucha wartości przedsiębiorstw. Takie podejście pozwala organizacji przyczynić się do podejmowania wyzwań związanych ze zrównoważonym rozwojem w odniesieniu do realizowanych procesów. Celem opracowania jest znalezienie odpowiedzi na postawiony problem badawczy: W jakich działaniach przejawia się wprowadzanie koncepcji Green BPM i jaki to ma związek z koniecznością raportowania ESG w sektorze finansowo-ubezpieczeniowym? Artykuł zwiększa wiedzę o mechanizmach i uwarunkowaniach wprowadzania Green BPM w sektorze finansowo-ubezpieczeniowym na przykładzie wybranego studium przypadku. Omawia związek Green BPM z raportowaniem ESG, przyczynia się do rozwoju wiedzy poprzez analizę i syntezę literatury na temat Green BPM, łączenie problematyki Green BPM z ESG, wskazanie kierunku możliwych przyszłych badań empirycznych skupiających się na tematyce cyfrowego śladu węglowego w działaniach Green BPM.
Zrównoważona konsumpcja i produkcja a zachowania konsumentów
Authors: Dąbrowska Anna , Shulhina Liudmiła
Published: July 2024

Jednym z 17 Celów Zrównoważonego Rozwoju jest zapewnienie wzorców zrównoważonej konsumpcji i produkcji. Dwunasty globalny cel odnosi się do promowania efektywnego zużycia energii i innych zasobów, trwałej infrastruktury, dostępu do podstawowych usług, godziwych miejsc pracy, w tym w sektorze środowiskowym, oraz lepszej jakości życia. Obejmuje trzy wymiary – gospodarczy/ekonomiczny, społeczny i środowiskowy. Szczególne znaczenie przypisano zmniejszeniu zużycia środków oraz skali degradacji i zanieczyszczeń. Celem artykułu jest identyfikacja zachowań polskich konsumentów w kontekście zrównoważonej konsumpcji i produkcji. Powodzenie działań w znacznej mierze zależy od konsumentów, ich społecznie odpowiedzialnych postaw w tych trzech wymiarach. Badania prowadzone przez Instytut Zarządzania SGH od 2021 r. pt. Barometr Społecznie Odpowiedzialnego Konsumenta wskazują na korzystne tendencje zmian. W niniejszym artykule przestawione zostaną wyniki IV edycji badania wskazujące na świadomość konsumentów wobec celu zrównoważonego rozwoju, czyli zrównoważonej konsumpcji i produkcji. Badania prowadzone są techniką CAWI na liczącej ponad 1000 osób próbie dorosłych Polaków, reprezentatywnej ze względu na wiek, płeć i klasę miejscowości zamieszkania.
Analysis of Impacts and Challenges of Online Learning During the Covid-19 Pandemic: A Case Study at SMA Negeri 2 Rantau Selatan
Authors: Sitompul Nurlaila , Siregar Zunaidy Abdullah
Published: July 2024

The COVID-19 pandemic outbreak in 2019 significantly impacted various aspects of societal life, particularly in education. The shift to online learning, necessitated by the pandemic, posed numerous challenges for teachers and students at SMA Negeri 2 Rantau Selatan. This study aims to comprehensively understand these difficulties faced by 11th-grade teachers during online instruction. Employing a qualitative descriptive approach, the findings reveal several challenges: difficulties in delivering the curriculum, evaluating students' understanding, and creating engaging online learning environments. Quantitatively, 75% of teachers reported significant challenges in curriculum delivery, 60% found it difficult to assess students' comprehension, and 70% struggled with maintaining student engagement. These findings suggest a need for more active and creative teaching methods, supported by adequate facilities from the government. The implications of these findings highlight the necessity for improved educational practices and policy recommendations to better support online learning.
Identifikasi Keragaman Mikroflora dan Pengaruhnya pada Kualitas Organoleptik Tempoyak Khas Suku Dayak di Kalimantan Tengah
Authors: Swestyani Sondra , Hujjatusnaini Noor
Published: July 2024

Tempoyak as local wisdom and national culture is poorly documented. Therefore, it is important to explore the preferences of the millennial generation regarding the organoleptic qualities of Tempoyak. The research design is a one-shot case study. The variables tested were the diversity of microflora in tempoyak, and its influence on the level of organoleptic quality and the level of preference of the millennial generation. Identification of isolates using API-50CHL, biochemical tests and physiological tests. Organoleptic quality uses the hedonic scale test. The research panelists were 120 people from the Dayak, Madura, Jawa and Banjar tribes. Data analysis uses one way Anava analysis. 15 isolates of microflora were found in Tempoyak which affected its taste and organoleptics, 8 isolates including lactic acid bacteria, including Pediococcus acidilactici, Lactobacillus curvatus, Leuconostoc mesenteroides, Lactobacillus plantarum, Streptococcus thermophiles, Lactobacillus pentosus, Enterococcus faecium, and Weissella paramesenteroides. 1 isolate of non-lactic acid bacteria that is Micrococcus varians. 2 isolates from the yeast group consisted of Saccharomyces cereviciae and Kluyveromyces marxianus, and 4 isolates included Rhizopus, Monilia sitophila, and Mucor roxii. All microflora found were capable of producing lactic acid, except Aspergillus repens. The statistical test results show the significance of its influence on the organoleptic quality of all sub-variables, including color, taste, aroma and texture of Tempoyak. The exploration results in this research indicate opportunities for Tempoyak to be more developed, innovative and contemporary, so that it is preferred by the millennial generation.
Eksplorasi Mikroflora Alami Produk Fermentasi Tradisional Cangkuak Berbasis Daging di Kecamatan Kuantan Mudik Kabupaten Kuantan Singingi
Authors: Putri Adela , Nurmiati Nurmiati , Periadnadi Periadnadi
Published: July 2024

Cangkuak is a fermented food made from meat with betung bamboo shoots or kluwak, salt and rice. The fermentation process is carried out without adding microbial cultures (spontaneous) for one to three weeks in a tightly closed container. cangkuak's manufacturing technique, ingredient formulation and constituent ingredients are unique, resulting in a final product with different characteristics. Research on the presence of microbes in fermented food products (fish, milk, vegetables) has been widely conducted, but information on exploring the presence of natural microflora and the in vitro potential of fermenting bacteria in cangkuak has never been reported. This research was conducted using a survey method and the resulting data were presented descriptively. It was found that the natural microflora found in the three samples of cangkuak in Kuantan Mudik was dominated by bacteria, with the highest proportion of bacterial groups in the three cangkuak samples being fermentative bacteria (2.0 - 6.30x105 cfu/g), cellulolytic bacteria (3.30 - 5.90x105 cfu/g), amylolytic bacteria (1.70 - 4.40x105 cfu/g), proteolytic bacteria (0.12 - 7.90x105 cfu/g), lipolytic bacteria (0.08 - 0.12x105 cfu/g). Six potential fermentative isolates were obtained as evidenced by the calculation of index values, namely DK-I1 (1.59), DR-I1 (1.36), DR-I2 (2.49), DR-I3 (1.19), DKR-I1 (2.41), and DKR-I2 (2.96).
Korelasi hs-CRP dan Keberadaan Staphylococcus aureus pada Luka Gangren Diabetes Mellitus Tipe II
Authors: Wahyuni Sri , Hasanah Fathul Hidayatul , Mu’arofah Binti , Jeferson Verdyan Taufan Rizky
Published: July 2024

Diabetes mellitus (DM) is a metabolic disorder that is accompanied  by an increased glucose in the blood or called hyperglycemia. Diabetes can be caused by problems with the pancreas not being able to produce insulin, insufficient insulin secretion, imperfect insulin action, or both. When blood glucose is left elevated for a long time, it can cause complications such as gangrene. Diabetic gangrene is one of the complications caused by tissue damage. Gangrene occurs due to neuropathy and vascular disorders, usually in the peripheral areas of the body. Bacteria found in diabetic wounds are bacteria that produce biofilms such as Staphylococcus aureus. Staphylococcus aureus can release exotoxins such as leukocidin. Leucosidine lyses PMNs and releases ROS which will then induce a cytokine response such as interleukin-6 which will increase CRP levels. hs-CRP is a high precision CRP measurement even at low concentrations.This study aims to determine the correlation between hs-CRP levels and the presence of Staphylococcus aureus in type II diabetes mellitus gangrene wounds. The research design used is observational analytical using a cross sectional approach and accidental sampling. There were 16 research respondents with increased hs-CRP levels in 15 respondents and 9 respondents with Staphylococcus aureus bacteria. Correlation test with a value of p = <0.05 (p=0.032) means that there is a correlation between hs-CRP and the presence of Staphylococcus aureus in type II diabetes mellitus gangrene wounds.
Notes on $q$-Partial Differential Equations for $q$-Laguerre Polynomials and Little $q$-Jacobi Polynomials
Authors: Bao Qi , Yang Dunkun
Published: July 2024

This article defines two common $q$-orthogonal polynomials: homogeneous $q$-Laguerre polynomials and homogeneous little $q$-Jacobi polynomials. They can be viewed separately as solutions to two $q$-partial differential equations. Furthermore, an analytic function satisfies a certain system of $q$-partial differential equations if and only if it can be expanded in terms of homogeneous $q$-Laguerre polynomials or homogeneous little $q$-Jacobi polynomials. As applications, several generalized Ramanujan $q$-beta integrals and Andrews-Askey integrals are obtained.
Combined Dopaminergic Drugs with Supplemental Progesterone to Treat Recurrent Miscarriage and Ulcerative Colitis despite Diminished Egg Reserve
Authors: Check Jerome H , Neumann Brooke
Published: July 2024

Rationale: Chronic inflammation of pelvic tissues related to increased cellular permeability may not only be responsible for diminished oocyte reserve (DOR) but may also contribute to recurrent miscarriage and other comorbidities. Objective: To determine if treatment with dextroamphetamine sulfate to release more dopamine from sympathetic nerve fibers to decrease excessive cellular permeability, and thus reduce excessive cellular immune activity, coupled with progesterone supplementation from luteal phase throughout the first trimester to increase the amount of the immunomodulatory protein the progesterone induced blocking factor (PIBF) could prevent another miscarriage in a 37-year-old woman with recurrent pregnancy losses. Findings: With this treatment, not only did she conceive in her first treatment cycle and delivered a full-term healthy baby, but the dextroamphetamine markedly improved her ulcerative colitis. Proof that the improvement of the ulcerative colitis was medication related and not merely fortuitous was determined by proving Koch’s postulates. The improvement was found to be long-lasting in that she has not had any symptoms of inflammatory bowel disease for 1 ½ years post-partum. Conclusions: Dopaminergic drugs plus progesterone should be considered first in women with DOR and a manifestation of potential excessive inflammation as evidenced in this case by inflammatory bowel disease. This is the second case report of improving treatment refractory ulcerative colitis with dextroamphetamine, which is considerably safer to the patient and more efficacious than the standard immune suppressants.
VENİZELOS’UN ÖLÜMÜNÜN TÜRK BASININDAKİ YANKILARI
Authors: Yıldırım Hatice
Published: July 2024

Venizelos’un ön plana çıkmasında ve siyasi hayatının başlamasında, doğum yeri olan Girit Adası’nın Yunanistan’a ilhakı için yürüttüğü faaliyetler önemli bir etken olmuştur. 1910 yılında iktidara gelmesiyle birlikte Megali İdea hayalini gerçekleştirmek için ülkesini Avrupa Devletleri’nin emperyalist politikalarına teslim eden Venizelos, aktif siyasetten uzak kaldığı dönemlerde bile Yunanistan’ın siyasi hayatı üzerindeki etkisini korumuştur. Dolayısıyla 1910-1933 yılları arasında Türk-Yunan ilişkilerinin şekillenmesinde Venizelos ve politikalarının önemli bir yeri bulunmaktadır. Siyasi hayatının ilk 10 yılında dış politikada Büyük Yunanistan hayaline sıkı sıkıya sarılan Venizelos, Türk-Yunan ilişkilerinde savaş ve çatışma sürecinin de baş aktörü olmuştur. Özellikle Balkan Savaşları ve Batı Anadolu’nun işgali döneminde Yunan askerlerinin Türk ahaliye karşı giriştiği katliamlardan takip ettiği politikalar nedeniyle Venizelos sorumlu tutulmuştur. Venizelos, Anadolu macerasının ilk yenilgisini ise 14 Kasım 1920’de Yunanistan’da seçimleri kaybederek almıştır. Seçim yenilgisinin ardından Yunanistan’dan ayrılan Venizelos, Avrupa’ya geçerek propaganda faaliyetlerine devam etmiştir. Ancak Megali İdea hayali ile başlattığı Küçük Asya Macerası Yunanistan için büyük bir felaket ile neticelenmesi Venizelos’un ve politikalarının da ikinci yenilgisi ve iflası anlamına gelmekteydi. Lozan Antlaşması’nın imzalanmasının ardından bir süre hem ülkesinden hem de siyasetten uzak kalan Venizelos 1928 yılında Yunanistan’da tekrar iktidara gelmiştir. Siyasi hayatının bu son yıllarında ise değişen konjonktür çerçevesinde Türk-Yunan ilişkilerinde dostluk sürecinin başlatılmasında önemli bir yere sahiptir. Bu bağlamda öncelikle iki ülke arasında iyi komşuluk ilişkileri tesis etmenin önündeki en önemli engel olan Lozan’dan kalan sorunları çözmek için girişimlerde bulunmuştur. Ardından da 30 Ekim 1930’da Ankara’yı ziyaret etmiştir.
Türk-Yunan ilişkilerinde basit bir tabirle önce düşman sonra dost olarak karşımıza çıkan Venizelos, 18 Mart 1936’da Paris’te vefat etmiştir. Bu çalışmada; başta dönemin ulusal basını ve yerelde ise 3 yıl Yunan işgali altında kalan İzmir basını incelemek suretiyle Venizelos’un ölüm haberinin Türkiye’deki yankıları ele alınmıştır.
PEMBUATAN APLIKASI PENGENALAN ANGKA DAN LOGIKA MATEMATIKA SEDERHANA UNTUK ANAK PAUD
Authors: Suhartono Andri ,   Institut Sains dan Teknologi Terpadu Surabaya, Yuliana Pram Eliyah , Ardhi Setya ,   Institut Sains dan Teknologi Terpadu Surabaya,   Institut Sains dan Teknologi Terpadu Surabaya
Published: July 2024

Mengenalkan angka dan mengajarkan ilmu berhitung pada anak-anak TK bukanlah hal yang mudah, dibutuhkan metode pengajaran yang smart dan menyenangkan agar anak-anak bisa memahami materi yang diajarkan. Apalagi anak-anak TK ini dalam tahap eksplorasi tentang segala hal mulai dari pengenalan warna, suara, bermain jari dan berhitung, meronce dan merangkai sesuatu, bermain pasir dan tanah, mengajak bermain lego (artikel epsikologi 1). Pendidikan yang dilakukan di lingkungan sekolahpun hanya dalam waktu yang singkat, hal ini untuk menghindari tingkat kebosanan yang nantinya bisa membuat anak menjadi tantrum yang akhirnya bisa berbahaya bagi anak itu sendiri (artikel Detik 2). Untuk menghindari hal-hal yang tidak diinginkan karena metode pengajaran yang salah, maka diperlukan tenaga pendidik (TenDik) yang handal. TenDik atau Guru haruslah memiliki wawasan, ketrampilan, dan kesabaran yang tinggi dalam proses belajar mengajar di Sekolah tersebut. Apalagi di beberapa Sekolah Dasar masih mensyaratkan penguasaan materi berhitung (Calistung) agar dapat diterima di sekolah tersebut. Oleh dari itu, tim pengabdi akan membuatkan Aplikasi Berhitung yang sederhana yang nantinya akan sangat mudah digunakan oleh para Guru dan siswa TK untuk mengenal angka dan logika berhitung sederhana. Selain itu, nanti juga akan dibuatkan perangkat yang terdiri dari Lampu LED sehingga semua orang bisa mengawasi dan ikut bermain dalam game ini. Dengan adanya aplikasi game dan perangkat nya diharapkan eksplorasi pengenalan angka dan belajar berhitung ini akan mampu menjadi salah satu metode yang dapat diterapkan di semua TK nantinya.
Концепция централизованной системы планирования реализации государственного земельного надзора и мониторинга земель
Authors: Добровольский Дмитрий Олегович , Портнов Алексей Михайлович
Published: July 2024

Исследование рассматривает структурные проблемы организации территориально распределенных типов контрольно-надзорных систем, их недостатки с учетом мирового опыта реализации надзорных практик в области землепользования. Приоритетным направлением для более эффективной реализации федерального государственного земельного контроля (надзора) и мониторинга земель в РФ предлагается концепция централизации процессов выявления возможных нарушений земельного законодательства и планирования надзорных мероприятий. В качестве новейшего информационного ресурса управления и развития системы земельного надзора и мониторинга земель в РФ следует рассматривать Федеральную государственную информационную систему «Единая цифровая платформа "Национальная система пространственных данных"» (ФГИС ЕЦП НСПД). Концентрируя в себе геоданные федеральных органов исполнительной власти, ФГИС ЕЦП НСПД следует рассматривать и как основу для разработки сервисов и автоматизированных процедур идентификации объектов, имеющих признаки нарушений земельного законодательства и существенных изменений геометрических и семантических свойств, что актуально для мониторинга земель. Одним из возможных способов идентификации объектов, имеющих признаки структурных изменений, предложено использовать понятие условной энтропии. Представлены примеры расчета значений условной энтропии для территорий с преобладанием потери лесного фонда. Такие исследования могут быть основой создания адаптивных моделей кадастрового состояния территорий как элемента государственной системы мониторинга земель и землеустройства. Проведенные исследования демонстрируют концептуальные преимущества централизации системы надзора, заключающиеся в прозрачности механизмов формирования плана проверок, определения наиболее значимых и критически важных объектов, подлежащих системному наблюдению, и организации природоохранных мероприятий.
Memórias afetivas
Authors: Ribeiro de Sousa Demmy Cristina
Published: July 2024

Neste texto apresento elementos da biografia, alegorias e reflexões sobre a composição coreográfica Mamootot (2003) de Ohad Naharin, coreógrafo israelense, que desde 1990 vem trabalhando à frente da Batsheva Dance Company na elaboração da linguagem de movimento que chamou de Gaga. Destaco o contexto histórico com o objetivo de identificar como a linguagem de Naharin se desenvolveu e destacar as principais correntes artísticas que moveram sua prática e sua linguagem até que ganhasse relevância internacional. Suscito questões sobre morte referente análise da obra Mamootot através das quais articulo as noções de corpo, aspectos pedagógicos a fim de alcançar alguma relação com Gaga. Utilizo como fontes entrevistas, textos e documentários produzidos através da imagem-fala do coreógrafo. Vale reforçar que a maior parte das informações contextualizadas até aqui foram colhidas no documentário britânico que conta com a fabulação de histórias sobre Naharin e seus feitos dentro da Batsheva produzido por Tomer Heymann, Mr. Gaga: A true story of love and dance (2015), traduzido para português como Gaga: o amor pela dança.
Das imagens que faltam à fabulação das memórias animadas em dois filmes ensaios
Authors: Rasia Regis Orlando
Published: July 2024

Este texto analisa o uso da imagem animada em dois filmes: "A Imagem que Falta", dirigido pelo diretor cambojano Rithy Panh, e "Valsa com Bashir", do diretor israelense Ari Folman. Ambas as obras destacam-se não apenas pelo modo como articulam suas narrativas, mas também pela abordagem dos traumas vividos pelos realizadores como testemunhos dos horrores da guerra. Questões relacionadas aos aspectos documentais e às fronteiras entre ficção parecem não dar conta para interpretar esses filmes. A ideia, então, é examinar essas obras à luz do filme-ensaio e compreender como a animação emerge como um dispositivo potente para lidar com uma ausência, uma lacuna, que o material de arquivo e o registro fotográfico por si só não conseguem abarcar. A animação, carregada por traços da imaginação e, sobretudo, por seus potentes regimes de fabulação, surge como um atravessador das memórias, explorando a expressão cinematográfica além das questões do realismo visual. Sendo assim, busca-se o inalcançável do arquivo e da imagem fotográfica, como ultrapassamento do interdito e a obscenidade da morte diante do horror da guerra.
Pensar o presente, reinventar o passado
Authors: Rodrigues Pereira Juliana , Plaza Pinto Pedro
Published: July 2024

“O que significa ser um comunista?” é a pergunta que Nanni Moretti tenta responder em alguns de seus filmes. Com algumas variações, ela é repetida em La sconfitta (1973) e Palombella rossa (1989), e está implícita em La cosa (1990) e O melhor está por vir (Il sol dell'avvenire, 2023). O esforço para respondê-la não é uniforme e está repleto de interrupções e descontinuidades, alternando entre um registro documental que parece minimizar a interferência do realizador e registros ficcionais elaborados a partir de elementos reconhecíveis do presente e do olhar retrospectivo que evidencia o papel rememorativo e especulativo do cinema na construção de um passado inventado ou de um futuro possível. E se o passado tivesse sido diferente? O objetivo deste artigo é refletir, por meio dos estudos sobre narratividade, sobre excertos dos mencionados filmes do produtor, diretor e ator. O procedimento metodológico da análise fílmica fornece pistas sobre como o cinema de Moretti se utiliza de diferentes materiais e estilos para pensar o presente, rememorar o passado e o fabular um futuro diante das crises e das adversidades. Neste artigo, estará em jogo especialmente o trabalho com a inserção do filme de Moretti dentro do filme de Moretti.
Review: Cancer and neurodevelopmental disorders: multi-scale reasoning and computational guide
Authors: Nussinov Ruth , Yavuz Bengi Ruken , Demirel Habibe Cansu , Arici M. Kaan , Jang Hyunbum , Tuncbag Nurcan
Published: July 2024

The connection and causality between cancer and neurodevelopmental disorders have been puzzling. How can the same cellular pathways, proteins, and mutations lead to pathologies with vastly different clinical presentations? And why do individuals with neurodevelopmental disorders, such as autism and schizophrenia, face higher chances of cancer emerging throughout their lifetime? Our broad review emphasizes the multi-scale aspect of this type of reasoning. As these examples demonstrate, rather than focusing on a specific organ system or disease, we aim at the new understanding that can be gained. Within this framework, our review calls attention to computational strategies which can be powerful in discovering connections, causalities, predicting clinical outcomes, and are vital for drug discovery. Thus, rather than centering on the clinical features, we draw on the rapidly increasing data on the molecular level, including mutations, isoforms, three-dimensional structures, and expression levels of the respective disease-associated genes. Their integrated analysis, together with chromatin states, can delineate how, despite being connected, neurodevelopmental disorders and cancer differ, and how the same mutations can lead to different clinical symptoms. Here, we seek to uncover the emerging connection between cancer, including pediatric tumors, and neurodevelopmental disorders, and the tantalizing questions that this connection raises.
“How can I get into the city center?”—pragmatic strategies at use in international tourism interactions in Croatia
Authors: Vida-Mannl Manuela
Published: July 2024

In Croatia, speaking many different languages is popular and perceived as a prestigious skill. English is one of the most commonly spoken additional languages and many Croats engage with it frequently, e.g., when watching undubbed American or British TV programs and movies. Due to this frequent engagement as well as the rise of English as a global language, especially younger Croats and those who work in the tourism sector tend to be quite proficient users of English. When interacting with tourists, Croats use accommodation strategies to cater to the tourists’ linguistic needs to increase understanding and communicative success (cf., e.g., Kaur, 2022 on pragmatic strategies). The present investigation centers on the specific pragmatic strategies present in such interactions between international tourists and local tourism workers and, based on a subset of 48 conversations recorded at the Franjo Tuđman Airport Zagreb, it illustrates the pragmatic strategies in the negotiation of directions to the city center. It shows that tourists and tourism workers tend to use the investigated pragmatic strategies in the following order of frequency: SMs>DMs>HMS>repetition>rephrasing>other features. However, taking a closer look, the study unveils how tourism workers balance the needs for efficiency and sociability when engaging with international tourists and offers a first take at understanding why the answers to similar questions often vary as the quality and quantity of the provided answers are influenced not only by linguistic factors.
‘Inter-ideologicality’ in intercultural communication education: co-constructing criticality around the concept of culture in international online student mobility
Authors: Peng Jun , Dervin Fred
Published: July 2024

The world has been experiencing huge upheavals since the COVID-19 crises. Conflicts caused by opposing ideologies, economic-political agendas and realities are rampant within or across borders. Such unsteady circumstances contribute to shifting how Transnational Education (TNE) occurs worldwide, as well as the scientific, epistemic and educational discourses that go with it. Anchored within critical interculturality, this paper explores the concept of ‘inter-ideologicality’. The study looks at short-term online international student mobility to demonstrate how students from China and Finland navigate and negotiate ideologies around the concept of culture in intercultural research and education. The study also employs Wang Chong’s perspectives on criticality to identify emerging ideologies in the co-construction of criticality in students’ online cooperation. Findings reveal that (1) two ideological orientations, nation-oriented and society-oriented, developed during discussions about culture; (2) Finnish students used a specific form of reasoning to contradict Chinese students’ thoughts about Finland by means of criticality towards the nation-oriented ideology; (3) Chinese and Finnish students employed questioning and challenging to help each other be aware of something left unsaid about the status of women in their societies within the society-oriented ideology. The study represents an important meta-approach to intercultural communication education within internationalization of Higher Education, aimed at supporting mobile students to reflect critically on the scientific and educational notion of interculturality rather than providing them with ready-made recipes as to how to communicate and behave interculturally.
A novel degradable PEG superparamagnetic iron oxide capsule coupled with a polyphenolic nano-enzymatic conjugate (PSPM-NE), to treat ROS-driven cardiovascular-diseases, tested in atherosclerosis as a model disease, and hypothesizing autoimmunity as an atheroma's trigger
Authors: Pereira Glaucia C.
Published: July 2024

Cardiovascular diseases account for a significant portion of the worldwide mortality rate. This aroused interest among the specialised scientific community, seeking for solutions based on non-clinical and clinical investigations, to shed light onto the physio-pathology of cardiovascular impairment. It is proven challenging managing chronic cardiovascular illnesses like atherosclerosis, arrhythmias, and diverse cardiomyopathies. In certain cases, there is no approved treatment. In other cases, the need for combining therapeutic components, when dealing with co-morbidities, may increase the risk of toxicity-driven cardiovascular impairment. In this case, because the risk of cardiac events correlates with the QT prolongation rates, the QT or QTc interval prolongation has become an important biomarker to access drug-related cardio-toxicity. Several approaches have been found in the current literature, aiming at improving physiological acceptance, i.e., to reduce toxicity. Nanotechnology has increasingly appeared as a promising ally to modulate active substances, preserving cardiovascular function and optimising drug effectiveness, i.e., acting as a cardio-protective mechanism, leveraging the effects of drug-driven cardio-toxicity. In this manuscript, the author combines plant active compounds and nanotechnological strategies, e.g., nano-encapsulation, nano-enzymes, magnetically driven nano-delivery systems, applied in regenerative medicine, and assesses their effects on the cardiovascular system, e.g., as cardio-protective factors, reducing cardio-toxicity. The aim is to propose a new strategy to tackle atherosclerosis initiation and progression, in a drug design that targets ROS-removal and reduces inflammation, using auto-immunity biomarkers to select key atheroma-related signalling cascades. To analyse physiological phenomena related to atherosclerosis initiation and progression, the author proposes both experimental observations and a new haemorheological computational model of arterial constriction. The results of such analysis are used as motivators in the design of the here presented strategy to tackle atheroma. This novel design is based on degradable polyethylene glycol (PEG) superparamagnetic iron oxide capsule coupled with a polyphenolic nano-enzymatic conjugate (PSPM-NE).
Outcomes of pulmonary endarterectomy for patients with pulmonary artery sarcoma
Authors: Zhang Zhaohua , Zhen Yanan , Liu Jingwen , Liu Xiaopeng , Yang Liang , Xu Mingyuan , Wen Jianyan , Liu Peng
Published: July 2024

Objective

Pulmonary artery sarcoma (PAS) is an exceedingly rare and insufficiently investigated disease, leading to uncertain in its optimal management. This study aims to present our institutional experience and the outcomes of pulmonary endarterectomy for PAS.

Methods

We gathered clinical characteristics, intraoperative data, postoperative outcomes, and prognosis information from PAS patients who underwent surgical treatment at our institution between December 2016 and September 2023.

Results

A total of 20 patients with PAS underwent pulmonary endarterectomy. The median age of the patients was 52 (IQR 45, 57) years, with 12 patients (60%) being female. Intimal sarcoma was confirmed in 19 patients, while the remaining one was diagnosed with large cell neuroendocrine carcinoma. The perioperative mortality rate was three cases (15%). Follow-up was conducted for a median duration of 14 months (range: 1–61). During the follow-up period, 11 patients experienced recurrence or metastasis, and 5 patients succumbed to the disease. The estimated cumulative survival rates at 1 and 2 years for all 20 patients were 66.4% and 55.3%, respectively.

Conclusion

Pulmonary endarterectomy emerges as a palliative but effective approach for managing PAS, particularly when complemented with postoperative therapies such as chemotherapy and targeted therapy, which collectively contribute to achieving favorable long-term survival outcomes.
AngioJet thrombectomy with extracorporeal membrane oxygenation support for an acute large-scale pulmonary embolism with bilateral atrial thrombosis: a case report of catastrophic antiphospholipid syndrome
Authors: Ji Jianyu , Jiang Lei , Wang Wei , Chi Xinyu , Dong Jinda , Lu Liqiu , Huang Minyan , Wei Xiutian , Pang Guangbao , Pang Jing , Xiong Bin , Xiang Shulin
Published: July 2024

Background

Catastrophic Antiphospholipid Syndrome (CAPS), a severe systemic autoimmune disorder, predominantly causes life-threatening multi-organ failure, with a high mortality rate. It primarily affects small vessels, seldom impacting large vessels. Notably, acute massive pulmonary embolism (PE) with bilateral atrial thrombosis is an exceptional occurrence in CAPS. Acute pulmonary embolism (PE) is a common cardiovascular disease that progresses rapidly and has a high mortality rate. Acute massive PE combined with bilateral atrial thrombosis has an even higher mortality rate. PE treatments primarily include pharmaceuticals, catheter interventions, and surgical measures, with integrated treatment strategies demonstrating promising outcomes in clinical practice. Extracorporeal membrane oxygenation (ECMO) can provide cardiopulmonary support for the treatment of high-risk PE patients and is a proven therapeutic measure.

Methods

This report presents the case of a 52-year-old male admitted due to fever and sudden onset of impaired consciousness, with cardiac ultrasound and pulmonary artery CT angiography revealing an acute large-scale pulmonary embolism accompanied by bilateral atrial thrombosis, with the condition rapidly worsening and manifesting severe respiratory and circulatory failure. With ECMO support, the patient underwent a thrombectomy using an AngioJet intervention. The diagnosis of CAPS was confirmed through clinical presentation and laboratory examination, and treatment was adjusted accordingly.

Results

The patient made a successful recovery and was subsequently discharged from the hospital.

Conclusion

In CAPS patients, the rare instance of acute massive PE accompanied by bilateral atrial thrombosis significantly risks severe respiratory and circulatory failure, adversely affecting prognosis. Early initiation of ECMO therapy is crucial, offering a vital opportunity to address the root cause. In this case report the patient was successfully treated with an AngioJet thrombectomy supported by ECMO.
Characteristics of intra-annual distribution of precipitation and incoming water and the synchronization analysis of their changes in the lower reaches of the Yangtze river basin
Authors: Kaidong Lu , Tingting Cui , Yintang Wang , Yong Liu
Published: July 2024

Precipitation and incoming water are the key contributing factors to local flooding events, and analyzing the intra-annual distribution and change characteristics of precipitation and incoming water will be beneficial to the understanding of flooding contributing factors in this region. In this paper, the characteristics of intra-annual distribution of precipitation and incoming water and the synchronization of their changes in the lower reaches of the Yangtze River Basin (LYRB) from 1980 to 2020 are studied using the concentration degree and concentration period as quantitative indicators. The results are as follows: 1) the maximum precipitation occurs earlier in the year, while maximum incoming water occurs with little variation in timing but significant variation in total volume; 2) the concentration degree of both precipitation and incoming water show a slowly decreasing trend. The concentration period of precipitation is slightly advanced, and that of incoming water is significantly delayed; 3) the occurrence time and concentration period of the incoming water peak during 2010–2020 lagged behind that of precipitation, which played a role in suppressing the occurrence of floods in the LYRB. This study can provide a scientific basis for the future supply and demand of water resources in the LYRB for safe use.
Improving the diagnostic performance of inexperienced readers for thyroid nodules through digital self-learning and artificial intelligence assistance
Authors: Lee Si Eun , Kim Hye Jung , Jung Hae Kyoung , Jung Jin Hyang , Jeon Jae-Han , Lee Jin Hee , Hong Hanpyo , Lee Eun Jung , Kim Daham , Kwak Jin Young
Published: July 2024

Background

Data-driven digital learning could improve the diagnostic performance of novice students for thyroid nodules.

Objective

To evaluate the efficacy of digital self-learning and artificial intelligence-based computer-assisted diagnosis (AI-CAD) for inexperienced readers to diagnose thyroid nodules.

Methods

Between February and August 2023, a total of 26 readers (less than 1 year of experience in thyroid US from various departments) from 6 hospitals participated in this study. Readers completed an online learning session comprising 3,000 thyroid nodules annotated as benign or malignant independently. They were asked to assess a test set consisting of 120 thyroid nodules with known surgical pathology before and after a learning session. Then, they referred to AI-CAD and made their final decisions on the thyroid nodules. Diagnostic performances before and after self-training and with AI-CAD assistance were evaluated and compared between radiology residents and readers from different specialties.

Results

AUC (area under the receiver operating characteristic curve) improved after the self-learning session, and it improved further after radiologists referred to AI-CAD (0.679 vs 0.713 vs 0.758, p<0.05). Although the 18 radiology residents showed improved AUC (0.7 to 0.743, p=0.016) and accuracy (69.9% to 74.2%, p=0.013) after self-learning, the readers from other departments did not. With AI-CAD assistance, sensitivity (radiology 70.3% to 74.9%, others 67.9% to 82.3%, all p<0.05) and accuracy (radiology 74.2% to 77.1%, others 64.4% to 72.8%, all p <0.05) improved in all readers.

Conclusion

While AI-CAD assistance helps improve the diagnostic performance of all inexperienced readers for thyroid nodules, self-learning was only effective for radiology residents with more background knowledge of ultrasonography.

Clinical Impact

Online self-learning, along with AI-CAD assistance, can effectively enhance the diagnostic performance of radiology residents in thyroid cancer.
Network analyses on photographic surveys reveal that invertebrate predators do not structure epibenthos in the deep (~2000m) rocky Powell Basin, Weddell Sea, Antarctica
Authors: Khan Tasnuva Ming , Griffiths Huw J. , Whittle Rowan J. , Stephenson Nile P. , Delahooke Katie M. , Purser Autun , Manica Andrea , Mitchell Emily G.
Published: July 2024

Predator-prey interactions in marine ecosystems control population sizes, maintain species richness, and provide intermediate disturbance. Such ecosystem structuring interactions may be rare in Antarctic epibenthic communities, which are unique among marine ecosystems worldwide for their dominance of soft bodied fauna (sponges, soft and hard corals, and echinoderms) and a simultaneous paucity of shell crushing predators (sharks, rays and durophagous decapods). In the shallow benthos, instead of durophagy, important Antarctic predators such as starfish, pycnogonids (sea spiders), nemertean worms, and nudibranchs employ grazing, scavenging, or sucking strategies. Far less is known about deep sea (>1000 m) Antarctic benthic communities due to the challenging nature of polar data collection, so that photographic surveys provide one of the only means of making in situ observations of these deep sea communities. We used seabed photographs of the deep (~2000m) slope of the Powell Basin, northwest Weddell Sea, taken by the Ocean Floor Observation and Bathymetry System on board the RV Polarstern (PS118, April 2019) to investigate the epibenthic community composition, and Bayesian Network Inference (BNI) to determine the ecological network, namely the ecological associations, including potential invertebrate predator-prey relationships between taxa. Photographs show that the rocky substrates of the basin slope support between 10-22 morphotaxa per photo, and highly abundant communities (density between 106 to 553 individuals/m2). BNI results reveal a network of associations between the sessile and mobile suspension and filter feeding organisms and their physical environment. However, associations between invertebrate predators like starfish, and other organisms, were not detected in the network. This lack of inclusion within the network suggests that, despite the presence of these normally important mobile predators, invertebrate predator-prey interactions on the rocky Powell Basin slope do not have the same ecosystem-regulating impact that they do on shallow Antarctic epibenthic communities.
A thorough investigation into the correlation between migraines and the gut microbiome: an in-depth analysis using Mendelian randomization studies
Authors: Zang Xuege , Du Yongkun , Jiang Mengshu , Zhou Shiyao , Wang Libo , Han Xuemei
Published: July 2024

Objective

A growing body of evidence underscores a significant association between neurological disorders, particularly migraines, and the gut microbiota. However, a research gap persists in understanding the cause-and-effect dynamics between these elements. Therefore, we employed robust methodologies aimed at thoroughly exploring the causal relationship between the gut microbiome and migraines.

Methods

Employing bidirectional Two Sample Mendelian Randomization (TSMR) analysis, we investigated the causal association between the composition of the gut microbiota and migraines. Data summarizing the relationship between gut microbiota and migraines were extracted from one or more genome-wide association studies. The TSMR analysis employed five methods to assess the correlation between the gut microbiota and migraines, with the inverse variance-weighted method serving as the primary approach for analyzing causal links. Sensitivity analyses were applied to address horizontal pleiotropy and heterogeneity. Simultaneously, a meta-analysis was performed to strengthen the robustness of the findings. Additionally, a reverse TSMR was carried out to explore potential occurrences of reverse causal relationships.

Results

The ongoing TSMR analysis identified a collection of 14 bacterial taxa connected to migraines. Among these, 8 taxa exhibited a protective effect, while 5 taxa had a detrimental impact, and 1 taxon maintained a neutral relationship. The reverse Mendelian randomization analysis highlighted stable outcomes for only one bacterial taxonomic group.

Conclusion

The study confirms a causal relationship between the gut microbiota and migraines, offering a new perspective for migraine research. Strategically targeting specific bacterial taxa with dysregulation may be effective in both preventing and treating migraines, thus opening new avenues for therapeutic strategies.
Towards optimized methodological parameters for maximizing the behavioral effects of transcranial direct current stimulation
Authors: Santander Tyler , Leslie Sara , Li Luna J. , Skinner Henri E. , Simonson Jessica M. , Sweeney Patrick , Deen Kaitlyn P. , Miller Michael B. , Brunye Tad T.
Published: July 2024

Introduction

Transcranial direct current stimulation (tDCS) administers low-intensity direct current electrical stimulation to brain regions via electrodes arranged on the surface of the scalp. The core promise of tDCS is its ability to modulate brain activity and affect performance on diverse cognitive functions (affording causal inferences regarding regional brain activity and behavior), but the optimal methodological parameters for maximizing behavioral effects remain to be elucidated. Here we sought to examine the effects of 10 stimulation and experimental design factors across a series of five cognitive domains: motor performance, visual search, working memory, vigilance, and response inhibition. The objective was to identify a set of optimal parameter settings that consistently and reliably maximized the behavioral effects of tDCS within each cognitive domain.

Methods

We surveyed tDCS effects on these various cognitive functions in healthy young adults, ultimately resulting in 721 effects across 106 published reports. Hierarchical Bayesian meta-regression models were fit to characterize how (and to what extent) these design parameters differentially predict the likelihood of positive/negative behavioral outcomes.

Results

Consistent with many previous meta-analyses of tDCS effects, extensive variability was observed across tasks and measured outcomes. Consequently, most design parameters did not confer consistent advantages or disadvantages to behavioral effects—a domain-general model suggested an advantage to using within-subjects designs (versus between-subjects) and the tendency for cathodal stimulation (relative to anodal stimulation) to produce reduced behavioral effects, but these associations were scarcely-evident in domain-specific models.

Discussion

These findings highlight the urgent need for tDCS studies to more systematically probe the effects of these parameters on behavior to fulfill the promise of identifying causal links between brain function and cognition.