bluuebunny/crossref_metadata_2025 huggingface dataset:
Oxidative stress, protein metabolism, and physiological potential of soybean seeds under weathering deterioration in the pre-harvest phase
Authors: Pinheiro Daniel Teixeira , Dias Denise Cunha Fernandes dos Santos , Silva Laércio Junio da , Martins Maycon Silva , Finger Fernando Luiz
Published: January 2023

Weathering deterioration affects seed quality, especially in areas with excessive rainfall. This study aimed to evaluate the oxidative stress, physiological quality, and protein metabolism of seeds of different soybean cultivars under weathering deterioration at the pre-harvest phase. Six soybean cultivars (BMX Apolo, DM 6563, NS 5959, NA 5909, BMX Potência, and TMG 1175) were subjected to simulated rainfall at the R8 stage. Each level was divided into two applications at 72-h intervals: 60 mm (30 + 30), 120 mm (60 + 60), and 180 mm (90 + 90). Then, the seeds were harvested and evaluated for physiological potential, antioxidative enzymes, hydrogen peroxide, malondialdehyde, proteins, and protease activity. The simulated rainfall allowed the variation in seed moisture, promoting a significant reduction in germination and seed vigor, especially at 120 and 180 mm levels. There were also reductions in antioxidative enzyme activity with weathering deterioration (mainly for catalase, ascorbate peroxidase, and peroxidase), accumulation of hydrogen peroxide and malondialdehyde, and reductions in protein content and protease activity. The proposed rainfall system is efficient in inducing weathering deterioration during the pre-harvest phase and its deleterious effects. Weathering deterioration in soybean seeds in the pre-harvest stage is directly influenced by genotype.
O pensamento computacional na educação para um currículo integrado à cultura e ao mundo digital
Authors: Vieira Kayenne Dias , Hai Alessandra Arce
Published: January 2023

O presente artigo é um estudo que por meio da análise das habilidades do pensamento computacional, apresentadas principalmente por Wing em 2006 (abstração, reconhecimento de padrões, decomposição e composição e raciocínio algorítmico), juntamente com os eixos cultura digital e o mundo digital procura se responder a seguinte questão: como o pensamento computacional pode ser incluído em currículos escolares integrando a educação ao mundo digital para além do simples uso de aparatos eletrônicos? Para tanto foi realizada a análise das diretrizes elaboradas pela Sociedade Brasileira de Computação e pelo Centro de Inovação para a Educação Brasileira voltadas ao ensino do pensamento computacional, que estruturou e especificou os conteúdos pertinentes à computação possíveis de serem incluídos em currículos escolares da educação brasileira, em acordo com a Base Nacional Comum Curricular. Assim, a inclusão dos eixos de habilidades descritos pela SBC vai ao encontro à integração do Pensamento Computacional favorecendo e oportunizando o desenvolvimento e a aquisição de novas habilidades e conhecimentos tecnológicos por meio de contextualização e identificação destes aspectos no cotidiano das crianças de forma significativa e crítica para que estes conhecimentos sejam apropriados pelos estudantes de modo atrelado ao currículo escolar e proporcionando novos meios de lidar com diferentes situações-problema.
Imigrantes norte-americanos de Santa Bárbara d’Oeste e Americana e o processo de transmissão de saberes análogo à educação técnica não formal (1865 – 1915)
Authors: Soffner Renato Kraide , Mialhe Jorge Luís
Published: January 2023

Este trabalho analisa o papel educativo dos norte-americanos sulistas emigrados dos Estados Unidos para o Brasil logo após sua derrota na Guerra de Secessão. A revisão de fontes históricas primárias e secundárias puderam confirmar o papel dos imigrantes no oferecimento de educação não formal agrícola às comunidades da região de Americana e Santa Bárbara d’Oeste – SP, no período histórico de 1865 a 1915. Dois personagens foram estudados em busca de fatos comprovatórios da hipótese aqui apresentada, qual seja, a de que o processo de transmissão de saberes, análálogo ao da educação não formal, provido pelos norte-americanos e seus descendentes imediatos teria provocado efeitos educativos e econômicos para as comunidades afetadas.
A valorização dos profissionais da educação: processo contraditório
Authors: Mourão Arminda Rachel Botelho , Costa Elinaldo Ferreira da , Nogueira Silvia Cristina Conde , Mendes Ione Maria Caetano
Published: January 2023

O artigo tem por objetivo questionar se a valorização dos trabalhadores em educação, é uma realidade ou apenas um discurso ideológico. Ao analisar a visão da Confederação Nacional dos Trabalhadores em Educação sobre os processos de valorização estabelece a crítica, salientando que ocorreram avanços ao conquistarem as normas legais, mas ocorreu um processo de ilusão de classe quando assevera que as normativas seriam cumpridas. Estabelece discussão teórica para subsidiar a luta em defesa da valorização dos profissionais da educação. A abordagem é crítico-dialética, já que intenciona desvelar os conflitos de interesses que se estabelecem nos movimentos sociais e discute processos de transformação da realidade social, ancorados na categoria trabalho fundante do ser social analisamos a partir do método a totalidade, práxis, contradição e mediação nos permitindo apreender a realidade que se apresenta como um todo estruturado. Afirmamos que de certa forma, as modificações que ocorrem na sociedade ampliaram o locus da luta e diferenciaram os sujeitos, dando maior visibilidade às diferenças e traçar táticas conjuntas requer a compreensão de que, neste momento, as diferenças ideológicas têm que ser superadas.
Orientação pedagógica e educacional nos Ginásios Vocacionais: interfaces entre pedagogia e psicologia (1961-1970)
Authors: Chiozzini Daniel Ferraz , Mannini Bartira , Compadre Natália Cardoso
Published: January 2023

O artigo consiste em parte de uma investigação acerca das interfaces entre Pedagogia e Psicologia nos Ginásios Vocacionais, escolas públicas de ensino secundário existentes entre 1961 e 1970 no estado de São Paulo. Foram analisadas e cotejadas com a bibliografia de referência fontes primárias que registraram trabalho de Orientação Pedagógica (OP) e Orientação Educacional (OE), possibilitando identificar essas áreas do currículo como espaço privilegiado da relação entre Pedagogia e Psicologia, sobretudo devido às temáticas abordadas e aos indícios de autores que embasaram a prática pedagógica. Nesse sentido, foram selecionados e analisados dois temas que ganharam relevo no trabalho escolar: composição de equipes de trabalho em grupo e educação sexual. Foi também constatado, no entanto, uma dificuldade em determinar a especificidade de cada uma das duas áreas e algumas mudanças emblemáticas no texto das fontes primárias utilizadas, possivelmente devido às mudanças políticas externas e internas às escolas ocorridas a partir de 1967.
Digital transformations of the process of professionalization of socionomics specialists on the basis of innovative pedagogical technologies
Authors: Kravtsova Nataliia , Tryfonova Olena , Povzun Liudmyla , Gultsova Diana , Gramatyk Nadiia , Bondarenko Svitlana Anatoliivna
Published: January 2023

The purpose of the study is identifying ways and providing conditions for the effective formation of professional competence specialists in the field of socionomics on the basis of innovative pedagogical technologies. The relevance of the study is due to the needs of practice in the constant professional and personal development of specialists socionomic sphere, given the demands of society. The problem of implementation is relevant for the modern development of vocational education innovative pedagogical technologies in providing personalized approach in the organization of the educational process of training socionomic spheres. It has established that education is becoming more and more innovative: the latest services of educational services are being created, there is an active digital transformation of the educational environment. The model of professional training of students for practical activities in the socionomic sphere is seen as a holistic system that includes a strategic goal - the formation of innovative thinking in the future specialist socionomic sphere who can effectively to carry out professional activity according to the requirements of international standards. The following components of professional competencies of socionomic specialists have distinguished: motivational, value-semantic, cognitive-professional, effective-professional, autopsychological, regulatory. It is proposed to focus on the development of skills of socio-professional interaction of the future specialist in the field of socionomics.
Cultural adaptation of the opening minds scale for health care providers(OMS-HC) for Brazil
Authors: Carrara Bruna Sordi , Ventura Carla Aparecida Arena , Costa Simone de Godoy
Published: January 2023

The Opening Minds Scale for Health Care Providers (OMS-HC) identifies health professionals' attitudes and behaviors towards people with mental illness. The aim of this study was to culturally adapt the OMS-HC for use in Brazil through the description of the translation and back-translation process, face and content validity assessment, and reliability assessment. The cultural adaptation occurred through translation of the original instrument, assessment, and synthesis of the translation by the Committee of Judges, back-translation, and pre-test. The cultural adaptation occurred without significant intercurrences, the changes resulting from the translations and assessments were, in general, specific and related to the changes of certain words by other synonyms for better adaptation. Cronbach's alpha was 0.74. The Brazilian version of the OMS-HC presented language adequate to the Brazilian context that is easy to apply, with adequate format for use, appropriate understanding, and consistency in relation to the original version. The Brazilian version of the OMS-HC is suitable for the development of a study to assess its psychometric properties.
Influence of mean value of the modulus of elasticity in compression parallel to the grain on the design of timber trusses
Authors: Gomes Arthur Filipe Freire , Almeida Filho Fernando Menezes de , Molina Júlio Cesar , Mascarenhas Fernando Júnior Resende , Lahr Francisco Antônio Rocco , Christoforo André Luis
Published: January 2023

The Brazilian standard ABNT NBR 7190 (Associação Brasileira de Normas Técnicas [ABNT], 1997) recommends adopting the mean value of the modulus of elasticity to compression in the direction parallel to the grain (Ec0,m) in the calculation of displacements. The values of wood stiffness vary considerably, and they can generate displacements above the limit (L 200-1, where L is the span) established by the referred standard, which contributes to the appearance of pathologies in the structure. To evaluate the influence of the adoption of Ec0,m in the calculation of displacements, mechanical properties of wood species were obtained experimentally. With the aid of numerical models and experimental values, ten types of trusses were analyzed (Porch, Inclined Chord, Top Inclined Chord, Parallel Chord, Bowstring, Fink, Howe, K Truss, Pratt, Scissor), three spans (5, 10, and 20 m) and two species (Hymenolobium petraum Ducke e Hymenolobium sp). Initially, adopting Ec0,m for all members and performing a linear analysis, the maximum loads for the displacement L 200-1 were determined. Subsequently, experimental stiffness values were randomly assigned to each bar, and the maximum displacements were determined through nonlinear geometric analyses. Based on 1260 numerical simulations, deflections of approximately 17% (span of 5 m), 30% (span of 10 m), and 34% (span of 20 m) were observed to be higher than the result considering Ec0,m. This problem can be overcome by using non-destructive methods in the pre-classification of the structure bars, positioning the elements rationally in the regions of the highest demand.
Mix design of large-stone asphalt mixtures for heavy-traffic roads
Authors: Mascarenhas Zila Maria Garcia , Beja Igor Amorim , Vasconcelos Kamilla , Bernucci Liedi
Published: January 2023

Heavy traffic and high temperatures are a common cause of rutting in paved areas, which reduces the time needed between pavement maintenance interventions. Large-stone asphalt mixtures (LSAMs) can reduce rutting when used as intermediate layers in pavement rehabilitation. LSAM is asphalt concrete with a nominal maximum aggregate size of at least 25 mm. In this study, we provide a brief literature review of the historical use of LSAMs, as well as the relevant characteristics of LSAM design. Three LSAMs were designed using different compaction methods: (i) Marshall compaction; (ii) rolling compaction; and (iii) Superpave gyratory compaction (SGC) by varying the compaction energy in 75, 100, and 125 gyrations. Depending on the mix design method used, the designed asphalt content ranged from 3.0 to 4.3%. The locking point from the SGC was evaluated at different gyratory compaction energies, which were related to the porosity of the dominant aggregate size range. These parameters are considered to be of great value when evaluating the LSAM design.
Goldenberry powder processing: analysis by a response surface methodology
Authors: Biasi Vanessa , Huber Eduardo , Barreto Pedro Luiz Manique
Published: January 2023

Goldenberry (Physalis peruviana) is a fruit of great interest for its nutritional properties and bioactive compounds, such as carotenoids. This study aimed to determine the ideal conditions for the development of a goldenberry powder. A Central Composite Design (CCD) was adopted to obtain response surfaces. For processing, different temperatures (50 - 70ºC) and times (27.18 - 32.82 hours) were used for dehydration of the fruits, evaluating the content of total carotenoids as a response and the moisture content around 15%. Data obtained were tested by analysis of variance (ANOVA) and fitted to a second-order polynomial equation using multiple regression analysis. An optimization study was carried out and the desirability function methodology was applied to find the ideal process condition. The optimization was determined at 52ºC and in a time of 27.18 hours, in which the experimental value obtained for total carotenoids was 12656.5 ± 527.22 mg 100 g-1 and moisture content of 15.00 ± 0.26%. In this condition, the global desirability value was 1.000 and the experimental values agreed with the predicted ones. Second-order polynomials were able to predict the carotenoids content in goldenberry powder, as well as the moisture content of the powder. The CCD and response surface tools were effective in optimizing the process. The production of goldenberry powder under these experimental conditions represents a viable alternative for adding value to the fruits, enabling the production of a potential food ingredient with carotenoid retention.
Low-cost multipurpose sensor network integrated with iot and webgis for fire safety concerns
Authors: Sacramento Iran Carlos Caria , Fernandes Vivian de Oliveira , Rösch Norbert , Marques Emerson de Andrade
Published: January 2023

Fire emergencies cause severe damage to Brazilian federal universities. An appropriate and efficient tool to prevent or detect such events early is multisensory networks from the Internet of Things (IoT). In this study, we present the stages of development of a WebGIS system which integrates the IoT that allows the detection and helps manage such incidents. The approach consists of a network of multipurpose sensors that can identify different sources of fire hazards. If a potential source is registered, information about environmental conditions is transmitted in real-time to the system. Depending on the severity level, an alert is issued to WebGIS. Location is represented on a map. The entire system consists of single-board devices. Software components are based on open-source tools. The whole network only needs little power and, therefore, theoretically, could be carried out as an autonomous system powered by batteries. The entire system has been tested with flame, temperature, gas, smoke, and humidity sensors. The experiments allowed us to show its potential, formulate recommendations and indications for future studies.
Paradoxical reaction in the treatment of tuberculous meningitis – pitfalls and challenges
Authors: Rameshkumar Thevarajah , Chang Thashi
Published: January 2023

Paradoxical reaction during the treatment of tuberculous meningitis (TBM) poses both diagnostic and therapeutic challenge in the management. We report a patient with miliary tuberculosis and TBM who developed an enhanced paradoxical reaction and discuss the challenges of its management. A 22-year-old woman presented with fever and headache for two weeks with features of meningism on examination. Miliary tuberculosis with TBM was diagnosed based on positive cerebrospinal fluid (CSF) and sputum Gene-Xpert MTB/RIF. The chest radiograph showed a miliary pattern. Six weeks after starting antituberculosis treatment (ATT), she presented with worsening headache and repeat magnetic resonance imaging (MRI) showed increase in the number and size of tuberculomas. Prednisolone dose was increased. At 10 weeks after starting ATT, her symptoms persisted, and MRI showed further worsening of lesions. Intravenous dexamethasone was administered and gradually tapered with oral prednisolone. This resulted in resolution of symptoms and radiological lesions. Paradoxical reaction in TBM is a recognized phenomenon during the treatment of tuberculosis. Awareness of this complication and its treatment can prevent the morbidity associated with this reaction.
The clinical profile of amyotrophic lateral sclerosis patients presenting to the National Hospital of Sri Lanka
Authors: Nandasiri Shanika , Silva Nirmali , Imitiaz Ilma , Gunaratne Padma , Senanayake Sunethra , Fernando Arjuna
Published: January 2023

OBJECTIVES Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease. Published data on ALS in Sri Lanka is scarce. The aim of this study was to describe the clinical profile of ALS patients presenting to the National Hospital of Sri Lanka(NHSL). METHODS A descriptive cross-sectional study was carried out in 33 consecutive patients with “clinically definite ALS” according to revised El-Escorial and Awaji criteria, who presented from May 2018-May 2020 to two neurology units at NHSL. RESULTS The mean age was 59.7 (±12.3) years while 57.6%(n=19) were males. The average duration for diagnosis was 15.48 (±12.4) months. The commonest first symptom was upper limb weakness 39.4%(n=13) followed by lower limb weakness 33.3%(n=11) and bulbar symptoms 27.3%(n=9). According to King’s Staging System, 18.2%(n=6) were in stage 1, 39.4%(n=13) were in stage 2, 36.4%(n=12) were in stage 3 and 3%(n=1) each were in stage 4A and 4B at the time of diagnosis. None had a family history of ALS. Four were treated with Riluzole. Out of all, 45%(n=15), 24.2%(n=8) and 6.1%(n=2) were referred for physiotherapy, occupational therapy and psychiatry assessment respectively. Seventy five percent (18/24) patients with bulbar symptoms, were referred to speech therapists and one had gastrostomy. Advance directives were not discussed with any of the patients. CONCLUSION The ALS patients presenting to the NHSL had a mean age of 59.7yrs with a slight male preponderance. The average duration taken for diagnosis was 15.5months while the commonest first presentation was upper limb weakness. Most present in King’s stage 2 or 3 and only a few were treated with disease modifying agents. Multidisciplinary care provided and management of disease related complications were suboptimal. Discussing about advance directives with ALS patients, is yet not part of Sri Lankan practice. This emphasizes the need to enhance standards of care for ALS patients to improve their quality of life.
Stephen Mitchell in Italia, 1988-1996
Authors: Conci Marco
Published: January 2023

Che cosa vuol dire recepire e promuovere in Italia l’importante opera di uno psicoanalista straniero? L’autore se ne occupa per quanto riguarda S.A. Mitchell (1946-2000), della cui opera fu il primo cultore italiano negli anni 1988-1996, riuscendo a contribuire a promuoverne una recezione superiore a quella di qualsiasi altro paese europeo.
Impact of COVID-19 on Mental Health of Health-Care Providers in Maharashtra
Authors: Kshirsagar Maya Vikas , Vaidya Saneeka Rajesh , Ashturkar Madhura Dhananjay
Published: January 2023

Background:

As COVID-19 is spreading rapidly, it is emotionally challenging for everyone. It has been observed that health-care workers come to play a major role and give their efforts to a greater extent in such situations. The studies have reported adverse psychological reactions to the 2003 severe acute respiratory syndrome outbreak among health-care workers. Hence, the study was planned to assess depression, anxiety, and stress among health-care professionals during the corona pandemic.

Materials and Methods:

A cross-sectional, observational study was carried out on health-care professionals working in the state of Maharashtra who were involved in the management of COVID-19 patients. Institutional ethical permission was taken before the study. The questionnaire was created to collect the data which having background information and the Depression, Anxiety, and Stress Scale-21. Data were entered into Microsoft Excel sheets and appropriate statistical analysis was done.

Results:

A total of 200 participants were included in the study. It was observed in our study that 51% of participants had depression, 38% had stress, and 49% had anxiety. Depression, anxiety, and stress were more among female health-care professionals than male professionals and it was statistically significant. It was found in our study that depression, anxiety, and stress were more in urban professionals than in rural health-care professionals, and the difference was statistically significant.

Conclusion:

As our study demonstrated a higher burden of depression, stress, and anxiety, early screening of health-care professionals and implementation of psychological interventions are essential for protecting and maintaining the functionality of the health-care system.
Gastrointestinal tract involvement in patients with potential celiac disease beyond the small intestine
Authors: Chauhan Ashish , Das Prasenjit , Singh Alka , Mehra Lalita , Rajput Mahender Singh , Agarwal Ashish , Dutta Rimlee , Mehta Shubham , Banyal Vikas , Ahmed Anam , Mehtab Wajiha , Ahuja Vineet , Makharia Govind
Published: January 2023

Background:

IgA anti-tissue transglutaminase-2 antibody (anti-TG2Ab) deposits in intestinal and extraintestinal organs have been used to link the respective pathological changes in these organs with celiac disease (CeD).

Aims:

To know if parts of intestine other than the duodenum, such as esophagus, stomach, and colon, have any pathology related to potential CeD or have mucosal IgA anti-TG2 Ab deposits.

Settings and Design:

A prospective case–control study conducted from April 2018 to December 2019.

Materials and Methods:

Nine patients with potential CeD and 27 age- and gender-matched patients with irritable bowel syndrome were recruited as cases and controls, respectively. Mucosal biopsies were collected from esophagus, stomach, duodenum, and rectosigmoid regions, histological changes were evaluated, and IgA anti-TG2 Ab deposits were analyzed in these regions by two-color immunohistochemical staining.

Statistics:

Data were analyzed using statistical software Stata 14.0.

Results:

No distinct difference in mucosal lymphocytosis were identified between biopsies of patients with potential CeD and controls at the following sites: esophagus (11.1% vs 0%, P = 0.079), stomach (14.3% vs 7.7%, P = 0.590), and rectum (20% vs 0%, P = 0.067). Co-localized IgA anti-TG2Ab deposits were observed more in potential CeD than in controls at esophagus 22.2% (2/9) vs 0%, P = 0.012; stomach 66.7% (6/9) vs 11.5% (3/26), P < 0.001; and duodenum 66.7% (6/9) vs 0%, P < 0.001 but not at rectum 0% (0/4) vs 0% (0/25).

Conclusion:

Although histological changes are not distinct, a subset of subjects with potential CeD has pan-intestinal involvement other than in the duodenum.
Burkholderia cepacia causing liver and splenic abscess
Authors: Nittala Radhika , Behera Manas K. , Panigrahy Rajashree , Narayan Jimmy , Mishra Debakanta , Singh Ayaskanta , Pati Girish K. , Patil Srinith , Sahu Manoj K.
Published: January 2023

Burkholderia cepacia infections are common among immunocompromised patients but multiple reports have shown that it can affect immunocompetent patients also. We are reporting two patients with multiple liver and splenic abscesses caused by Burkholderia cepacia. First case is a 54-year-old diabetic male presenting with fever, abdominal pain, bilateral lower limb weakness, and incontinence of urine. Second case is a 41-year-old male presenting with fever and confusion. Both had liver and splenic abscesses. Pus aspirated from the abscesses grew Burkholderia cepacia. Both responded to cotrimoxazole. Our case report emphasizes growing incidence of Burkholderia cepacia in immunocompetent patients.
Can CXCL13 be a prognostic marker in clear cell renal cell carcinoma?
Authors: Sayar Esma , Yabacı Ayşegül , Coban Ganime
Published: January 2023

Background:

CXCL13, B-lymphocyte chemoattractant, has been associated with many diseases and cancers. One of the malignancies that CXCL13 has been investigated is clear cell renal cell carcinomas which are the most common subtype of renal cancers.

Aims and Objectives:

The aim of this study is to evaluate the immunohistochemical staining patterns of CXCL13 in clear cell renal cell carcinomas and to determine its relationship with pathological tumor stage, risk factors, and prognostic parameters.

Materials and Methods:

In this study, 99 patients who underwent partial/radical nephrectomy diagnosed with clear cell renal cell carcinoma were included. Four micron sections were taken from paraffin embedded blocks containing sufficient tumor and kidney tissue. Samples were immunohistochemically stained with CXCL13 antibody. During microscopic examination, CXCL13 positive stained cells in ten high magnification fields were counted and evaluated using a semiquantitative H score: 3 × strongly stained + 2 × moderately stained + 1 × weakly stained. The cut-off value was set as 40 for values between 0 and 300. The low and high stained groups were compared with prognostic parameters and risk factors.

Statistics:

The difference of continuous variables between the two groups was examined with the t test and the distribution of categorical variables with the Chi-square test. A value of P < 0.05 was considered to be statistically significant.

Results:

The number of lymphocytes stained with CXCL13 in the tumor was higher than in the normal kidney parenchyma (p = 0.07). Intratumoral lymphocytes were highly stained with CXCL13 in 57.5% of pT3 cases and 31.7% of pT1 cases. The amount of intratumoral lymphocytes stained with CXCL13 increased in advanced pathological stages (p = 0.05). Nonsmoking cases were mostly in the low staining group (p = 0.06).

Conclusion:

The relationship we found between advanced pathological stage and intratumoral CXCL13 staining in our study suggests that CXCL13 has a prognostic value in this cancer.
Study of growth differentiation factor-15 in polytransfused children with β-thalassemia
Authors: Meena Swati , Sharma Kusha , Sharma Sunita , Chandra Jagdish
Published: January 2023

Background:

Ineffective erythropoiesis is a predominant feature in β-thalassemia major (β-TM), causing marked erythroid expansion leading to highly raised levels of growth differentiation factor-15 (GDF-15), which, in turn, suppresses hepcidin production in liver resulting in increased iron absorption from gut. We aim to study the serum GDF-15 in polytransfused β-TM patients and its correlation with serum ferritin and serum hepcidin.

Method:

Thirty-nine polytransfused β-TM children aged between 5 and 17 years and 33 age- and gender-matched healthy controls were enrolled in the study. Complete blood count, serum GDF-15, serum ferritin, and serum hepcidin were performed.

Results:

The mean serum GDF-15, serum hepcidin, and serum ferritin levels were 638.65 ± 306.96 pg/ml, 108.21 ± 191.30 ng/ml, and 2274.60 ± 1216.08 ng/ml, respectively, which were significantly higher than control group (P < 0.001, P = 0.003, P < 0.001, respectively). There was significant positive correlation of GDF-15 with blood transfusions (r = 0.415, P = 0.009), positive correlation with serum ferritin (r = 0.653, P = 0), and significant negative correlation with serum hepcidin (r = −0.508, P = 0.001).

Conclusion:

The findings of the present study suggest that GDF-15 is an important regulator of hepcidin in β-TM patients. GDF-15 and serum hepcidin together can be used to monitor iron overload and its related complications in such patients.
Immunohistochemical appraisal of epithelial mesenchymal transition type III in gall bladder cancer
Authors: Yadav Kamini , Agarwal Preeti , Kumar Madhu , Gupta Sameer , Mishra Medha , Maurya Malti Kumari , Qayoom Sumaira , Goel Madhu Mati
Published: January 2023

Background:

Epithelial-mesenchymal transition (EMT) is the heart of invasion. EMT associated with cancer progression and metastasis is known as type III EMT. Beta-catenin, E-cadherin, and MMP9 markers of EMT are routinely employed for diagnostic purposes.

Aims:

We employed these markers to study EMT by immunohistochemistry (IHC) in gall bladder cancer (GBC) with respect to depth of tumor invasion, clinical outcome, and disease-free survival.

Settings and Design:

This was a prospective case-control study.

Material and Methods:

Seventy gall bladders were included (50 GBC and 20 CC). After detailed histology, immunoexpression was studied in terms of percentage and strength of expression.

Statistics Analysis Used:

Expression was compared between CC and GBC by Student t test and analysis of variance. Kaplan–Meier was used for survival analysis, and the extent of agreement (“Kappa”) was calculated.

Results and Conclusions:

The age of incidence of GBC was 49.40 (+11.6) years with female predominance (F:M = 4:1). In 88% (44/50) of GBC, the fundus was involved. Moderately differentiated adenocarcinoma was most frequent [54%; 27/50]. Significant downregulation of E-cadherin (P = 0.022) and beta-catenin (P < 0.001) and upregulation in MMP9 (P < 0.001) were seen in GBC with respect to CC with significant association among them. MMP9 expression was significantly associated with higher tumor stage but with chemotherapeutic response. Our results display that epithelial-mesenchymal transition type III plays a role in GBC invasion. MMP9 overexpression and loss of membranous beta-catenin may be considered a marker for poor clinical outcomes and advanced disease.
Left renal vein thrombosis in a COVID-19 patient
Authors: Vaghdevi Cherukuru Namratha , Sindhu Dara , Jahnavi Bommu , Chowdary Dondapati Pooja , Gaddam Sri Lakshmi , Aishwarya Pavuluri Lakshmi , Murali Muparapu , Mathani S. , Kumar Prasanna , Ram R. , Kumar V. Siva
Published: January 2023

The multiorgan deleterious effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) disease (COVID-19) are now well known. Although COVID-19 disease is a hypercoagulable state and thrombotic complications occur in about one-third of critically ill patients with COVID-19, thrombosis is not typically a presenting symptom. We report the case of a patient presented with the complaints of abdominal pain due to renal vein thrombosis as the first feature of the COVID-19.
Modified radical mastectomy under paravertebral block in a patient diagnosed with active pulmonary tuberculosis with moderate restriction of pulmonary function
Authors: Uns Mohammad Abuzahid , Reddypogu Dyva Manogna , Valli M. Sneha
Published: January 2023

Mastectomy is mostly performed as definitive management for resectable breast cancer (BC). Implementing paravertebral nerve block for patients with metastasis features of cancer to lungs and other organs, patients with co-morbidity, geriatrics and malnourished individuals will eliminate the risks and complications of general anaesthesia (GA). Although thoracic paravertebral block is an established technique as post-operative pain management for breast surgery, there is no conclusive evidence on its use as a sole anaesthetic for modified radical mastectomy (MRM). In this case report, we present a 45-year-old woman who underwent a successful MRM for Stage IIIb BC associated with pulmonary tuberculosis with moderately restricted pulmonary function test under paravertebral nerve block. We believe that paravertebral nerve block can be used as an alternative anaesthetic technique for MRM in a resource-limited setting for patients who are expected to have a high risk of perioperative complications under GA.
Survival and prognostic factors among hospitalized pancreatic cancer patients in Northwestern Iran
Authors: Vahedi Leila , Asvadi Kermani Touraj , Asghari-Jafarabadi Mohammad , Asghari Elham , Mohammadi Seyedeh Momeneh , Khameneh Amin
Published: January 2023

Background:

Pancreatic cancer (PC) is associated with a poor prognosis, with various modifiable risk factors affecting the survival of patients. Our aim was to evaluate the survival rate and the prognostic factors influencing survival in PC patients in northwestern Iran.

Materials and Methods:

All the PC patients admitted to the Imam Reza Hospital of Tabriz, Iran, from 2016 to 2020, were enrolled in this study. The survival rate and time were calculated, and the risk factors related to survival were evaluated by Cox regressions. The data were analyzed using the Cox proportional hazards model using STATA software.

Results:

Of 110 patients, 12-, 24-, 36-, and 48-month survival rates were 29.1%, 19.8%, 14.1%, and 8.5%, respectively, with the median survival time of seven months. The mean age was 65.5 years. The results showed that a higher age (hazard ratio [HR] [95% confidence interval (CI)] = 2.04 [1.20–3.46]), lower education (1.72 [1.03–2.89]), delayed diagnosis (1.03 [1.02–1.05]), hypertension (1.53 [1.01–2.31]), concomitant heart disorders (2.67 [1.50–4.74]), COPD (4.23 [1.01–17.69]), consanguineous marriage (1.59 [1.01–2.50]), and the presence of icterus complications (adjusted HR = 3.64 [1.56–8.49]) were directly associated with a worse survival. On the contrary, radiotherapy (0.10 [0.01–0.85]), chemotherapy (0.57 [0.36–0.89]), and surgical therapy (AHR = 0.48 [0.23–0.99]) were directly related to a good prognosis.

Conclusion:

Surgery, chemotherapy, and radiotherapy were the best predictors of survival in PC patients. Moreover, it seems that resolving jaundice can improve survival in these patients. It seems that increasing social awareness, treating underlying diseases, and employing an appropriate therapeutic method may promise a better outlook, improve the survival rate of patients, and reduce PC risk.
Effectiveness of dynamic strength-endurance training of the neck and scapular muscles in reducing pain and improving function in nonspecific neck pain
Authors: Priya S. , Haripriya S. , Dhungana Milan
Published: January 2023

BACKGROUND:

Nonspecific neck pain is a common musculoskeletal disorder causing disability among the general population. Specific dynamic strength-endurance exercises may help maintain improved posture, which in turn can lessen or eliminate recurrent flare-ups of pain. The effect of exercise on patients with chronic nonspecific neck pain has been investigated in several studies. The efficacy is, however, questionable.

AIM:

The aim of the study is to find the effectiveness of dynamic strength-endurance training in reducing pain and improving function in nonspecific neck pain.

DESIGN:

This study was a pre- and postintervention design.

SETTING:

This study was conducted in tertiary care hospital in Mangaluru.

MATERIALS AND METHODS:

In this pre- and postexperimental study, dynamic strength-endurance training for cervical and scapular muscles was given to 24 adults fulfilling inclusion criteria for 4 weeks. The Neck Disability Index (NDI) was used for pain and disability assessment, and the Neck Bournemouth Questionnaire (NBQ) and the Northwick Park Neck Pain Questionnaire (NPNQ) were used for pain assessment.

RESULTS:

There was a significant reduction in NDI, NBQ, and NPNQ scores exceeding minimal clinically important difference (NDI >7.5 points, NBQ >5.5 points, and NPNQ >7.6 points) after 4 weeks of strength-endurance training of cervical and scapular muscles. There was significant improvement in hold time. Statistically, a significant difference was observed in pre- and posttreatment effect comparison of all outcome measures (P > 0.01).

CONCLUSION:

A dynamic strength-endurance training program is effective in reducing pain and disability in a patient with nonspecific neck pain.
Efficacy of Olaparib in Treatment-Refractory, Metastatic Breast Cancer with Uncommon Somatic BRCA Mutations Detected in Circulating Tumor DNA
Authors: Yoon Jung-Ki , Ahn Jongseong , Kim Sheehyun , Kim Hwang-Phil , Kang Jun-kyu , Bang Duhee , Lim Yoojoo , Kim Tae-You
Published: January 2023

Poly(ADP-ribose) polymerase inhibitors have been shown dramatic responses in patients with BRCAness. However, clinical studies have been limited to breast cancer patients with germline mutations. Here, we describe a patient with metastatic breast cancer who had a rare BRCA1 somatic mutation (BRCA1 c.4336G>T (p.E1446*)) detected by cell-free DNA analysis after failing standard therapies. This tier III variant of unknown significance was predicted to be a pathogenic variant in our assessment, leading us to consider off-label treatment with olaparib. The patient responded well to olaparib for several months, with a decrease in allele frequency of this BRCA1 somatic mutation in cell-free DNA. Olaparib resistance subsequently developed with an increase in the allele frequency and new BRCA1 reversion mutations. To our knowledge, this is the first report confirming BRCA1 c.4336G>T (p.E1446*) as a mutation sensitive to olaparib in breast cancer and describing the dynamic changes in the associated mutations using liquid biopsy.
Плотность нулей функций класса Картрайт и
условие Хельсона-Сегe
Authors: Avdonin Sergei Anatol'evich , Ivanov Sergei Alekseevich
Published: January 2023

Б. Я. Левин доказал, что множество нулей функции типа синуса
может быть представлено как объединение конечного числа
отделимых множеств, что является важным результатом
в теории экспоненциальных базисов Рисса. В настоящей работе
мы распространяем результат Левина на более общий класс
целых функций $F (z)$ с нулями в полосе
$\sup|{\operatorname{Im}\lambda_n}|<\infty$ такой, что $|F(x)|^2$
удовлетворяет условию Хельсона-Сегe. Более того, мы доказываем,
что вместо последнего условия можно потребовать,
чтобы $\log|F(x)|$ принадлежал классу BMO.
Библиография: 19 названий.
Преобразования Фурье сверток функций из пространств Лебега и Лоренца
Authors: Golubov Boris Ivanovich , Volosivets Sergei Sergeevich
Published: January 2023

Приводятся условия весовой интегрируемости преобразований Фурье сверток функций из пространств Лоренца и Лебега, а также количественные оценки, связанные с этой интегрируемостью. Доказывается неулучшаемость полученных результатов.
Mitigation Strategies in Semi-structured Oral Chinese Interviews
Authors: Querol-Bataller Maria
Published: January 2023

This paper identifies and accounts for mitigation strategies in a corpus of language that attempts to reflect the communicative style of Chinese speakers in semi-structured oral interviews. Thus, the analysis was carried out on the informal conversations of the C-ORAL-CHINA corpus. Mitigating resources were classified and grouped into seven general procedures that constitute different strategic mechanisms with which mitigation is carried out. Regarding the strategic mechanisms through which mitigation was carried out in these semi-structured oral Chinese interviews, the most common strategies were the following: the use of resources that downgrade what has been said or done, the use of resources that involve the addressee in what has been said or done, and the use of resources that limit or restrict what has been said or done. Conversely, the strategies of correcting or repairing what has been said, justifying, and defocalizing had the lowest frequency of use.
The Role of Prototypical Transitivity in the Selection of Accusative Case Particle wo by Persian Learners of L2 Japanese
Authors: Chauhan Anubhuti , Hosseini Ayat
Published: January 2023

This study attempts to account for Japanese language learners’ selection pattern of case particle wo by taking a prototype-based approach to language learning. A cross-sectional study of Persian-speaking learners was conducted to examine whether the degree of predicate transitivity influences case particle selection, and whether proficiency level and L1 play a role in such a selection pattern. The results reveal that learners were sensitive to the degree of predicate transitivity. However, the test scores were significantly higher for verbs of contact (‘throw’, ‘use’) which express object manipulation compared to those for the linguistic prototype which involves a change in the object’s state (‘cut’, ‘reduce’). This suggests that learners may consider contact verbs as the more ‘typical’ or basic transitive construction. The results also show that lower proficiency learners were more likely to select particles based on L1 surface marking, suggesting that learners’ particle selection strategy is influenced by proficiency level.
Validity-Reliability Study of the Patient’s Assessment of Quality Scale-Acute Care Version for Turkish Society and Determine of the Quality of Nursing Care Received by Patients
Authors: AKBAŞ Meltem , İBİCİ AKÇA Emine , ONAT KÖROĞLU Cemile , GÖKYILDIZ SÜRÜCÜ Şule
Published: January 2023

Objective: The aim of this study is to contribute to the literature by realizing the reliability and validity of the Patient Quality Assessment Scale-Acute Care Version and to determine the quality of nursing care received by hospitalized patients.Methods: This study is methodological and descriptive. This study was conducted in four different hospitals in a city located in the southern part of Turkey. Data were collected by the researchers using the “Patient Information Form” and the “Patient Quality Assessment Scale-Acute Care Version”. Statistical analyses were performed using the IBM SPSS Statistics 22 and AMOS. Statistical significance was taken p<0.05.Results: After the analysis, the CFA fit indices of the Patient Quality Assessment Scale-Acute Care Version were found in the appropriate range and the Cronbach alpha coefficient was 0.971. The Patient Quality Assessment Scale-Acute Care Version total mean score was 136.63±21.47. Perceptions of patients regarding Quality Nursing Care were affected by factors such as the type of hospital, patients’ diagnosis, place of living, level of satisfaction with the nursing care received, and finding the nursing care sufficient. Conclusion: The Turkish version of the Patient Quality Assessment Scale-Acute Care Version was found valid and reliable for Turkish society. The patients found the quality of the nursing care received above-average. The results of the study should be used by hospital management, health care policy developers and nurses to increase the quality of nursing care. Nurses should consider patients' perceptions of nursing care, their experiences, factors affecting nursing care, and individual differences of patients in order to improve the quality of nursing care.
Profile of Students' Misconceptions on Substance Pressure Using a Three-tier Diagnostic Test
Authors: Putri Oktavia Damayanti Aji , Prastowo Tjipto , Sanjaya I Gusti Made
Published: January 2023

Research aims to find out misconceptions experienced by students on the subject matter of substance pressure. This type of research is quantitative descriptive research using a survey method. The instrumental test used was a three-tier diagnostic test to determine the under-examined misconceptions. The research sample consisted of 43 junior high school students who had previously received substance-pressure learning materials in class. The data were analyzed by categorizing them into understanding the concept, needing more knowledge, errors, and misconception. The results of the study were as follows: (1) 9% of the students understood the concept, 51% of the students had a misconception, 34% of the students were lack of knowledge, and 6% of the students had some errors (2) misconceptions with the highest percentage were in the sub-concept of pressure gases with an average percentage of 70%, then the pressure of liquids (capillarity and osmosis in plant stems) was 52%, the pressure of solids was 51%.
The Role of Scientific Literacy Instruments For Measuring Science Problem Solving Ability
Authors: Afnan Rizqi , Munasir Munasir , Budiyanto Mohammad , Aulia Mochammad Izzur Rizky
Published: January 2023

A critical aspect of measuring judgment in the 21st century is scientific literacy. In addition to the scientific literacy aspect as part of the grade 21 skills assessment, there are other essential aspects, namely student problem-solving skills. Based on the articles collected, it can be concluded that to meet the necessities of life in various situations in the global era, Literacy ability is a fundamental thing that all students must own. The role of scientific literacy instruments is needed to measure students' science problem-solving abilities. Because scientific literacy is an individual's ability to identify, explain and conclude scientific evidence by using the ability to solve problems based on how to understand, plan, solve, and reassess. This can be seen from the many theories and teaching methods that support the results obtained from the forty-four journals reviewed. The criteria for the articles used are those published in 2017-2022. The purpose of this article review is to determine the role of scientific literacy instruments in measuring students' problem-solving abilities by using a literature review that gathers sources from several previous articles.
The Principal's Strategy for Strengthening National Identity in Globalization Era
Authors: Sarmini Sarmini , Suprijono Agus , Susilowati Indri Fogar , Achmadi Charis , Rizaq Agung Dwi Bahtiar El
Published: January 2023

National identity is interesting to be discussed, considering the loss of national boundaries since technological advances increasingly affect daily life. National identity is essential to be implemented from an early age, primarily through the role of education. The focus of this study is to reveal the Principal's strategy for strengthening national identities. This study was conducted using a quantitative approach through a survey of 50 elementary school principals spread over 18 subdistricts in the Sidoarjo Regency. Two things can be concluded from this study. First, national identity is essential for the young generation of mid-globalization. This study shows that every respondent realizes the importance of principal secondary schools developing straightforward policy programs about internalizing national identity. Those policy programs must integrate extracurricular activities, extracurricular activities, building school culture, and various participation activities. Second, most of the respondents agree that their schools have no clear policy as their guidance in internalizing national identity values in learning. Several teachers have integrated national identity values into learning through lesson plans or learning activities. This study recommends developing an applicable policy model to strengthen the national identity of the young generation.