bluuebunny/crossref_metadata_2025 huggingface dataset:
General introduction and book layout
Authors: Bertrand-Krajewski Jean-Luc , Clemens-Meyer Francois H. L. R. , Lepot Mathieu
Published: August 2021

This introductory chapter indicates why well-defined, high-standard, and reliable monitoring is a key aspect in the necessary evolution of urban drainage and stormwater management and why it should become routine practice. It provides a framework, guidelines, and recommendations to define monitoring objectives and means. It also presents the structure and the chapters of the rest of the book.
Water level and discharge measurements
Authors: Larrarte Frédérique , Lepot Mathieu , Clemens-Meyer Francois H. L. R. , Bertrand-Krajewski Jean-Luc , Ivetić Damjan , Prodanović Dusan , Stegeman Bram
Published: August 2021

The knowledge of water levels and discharges in urban drainage and stormwater management (UDSM) systems is of key importance to understand their functioning and processes, to evaluate their performance, and to provide data for modelling. In this chapter, devoted mainly to underground combined and separate sewer pipe systems, various methods and technologies are described and discussed. After an introduction to important aspects to deal with when measuring discharges in sewer systems, the following parts are presented successively: (i) measurement of water level with rulers, and pressure, ultrasonic and radar sensors, (ii) measurement of flow velocity with ultrasonic, Doppler, velocity profiler, free surface, and electromagnetic sensors, (iii) direct measurement of discharge with pre-calibrated devices, physical scale models, computational fluid dynamics modelling and use of pumping stations, and (iv) detection and/or measurement of infiltration into and exfiltration from sewers, with flow or pressure measurements, tracer experiments, distributed temperature sensing and geophysical methods.
Critical Functions of lncRNA DGCR5 in Cancers of the Digestive System
Authors: Hu Chengyu , Xu Wen , Wang Bei , Chen Jinlan , Zhou Zixian , Zhou Gang , Yuan Chengfu
Published: August 2021

Background:

Long non-coding RNAs (lncRNAs) has no protein-coding potential due to the lack of
an apparent open reading frame. There is growing evidence that lncRNA DGCR5 has a vital regulatory role in
human illnesses' pathological development, particularly in the digestive system's carcinogenesis and progression.
Abnormal DGCR5 expression affects different cellular functions such as proliferation, aggression, and
metastasis. This paper aims to probe into the pathophysiological functions and molecular mechanisms of
DGCR5 in cancers of the digestive system.

Methods:

This review summarizes and analyzes the biological functions and mechanisms of lncRNA DGCR5
in digestive system cancers occurrence. Relevant studies were conducted and reviewed by searching PubMed
for articles with lncRNA DGCR5 and digestive system cancer as keywords in recent years.

Results:

DCGR5, as a novel tumor-related lncRNA, is recently identified to be abnormally expressed in digestive
system cancers, such as pancreatic ductal adenocarcinoma, pancreatic cancer, gastric cancer, gallbladder
cancer, colorectal cancer, and hepatocellular carcinoma. The role played by DCGR5 is vital and varies in different
digestive cancers. Taken together, aberrant expression of DCGR5 regulates the progression of digestive
cancers by affecting cancer cell proliferation, aggression, metastasis, and drug resistance.

Conclusion:

LncRNA DGCR5 might be a viable marker or a promising therapeutic target in digestive system
cancers.
Withdrawal Notice: Community-wide Screening of Symptomatic and Asymptomatic Infection of Mycobacterium tuberculosis in the Saharia tribe of India
Authors: Singh Pushpendra , Kumar Ravindra , Das Aparup
Published: August 2021

The article has been withdrawn at the request of the authors and editor of the journal Combinatorial Chemistry & High
Throughput Screening.

Bentham Science apologizes to the readers of the journal for any inconvenience this may cause.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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is transferred to the publishers if and when the article is accepted for publication.
An Audit of Black Box Warnings (BBWs) in the United States Food and
Drug Administration (US-FDA) Database - A Five-Year Analysis
Authors: Bose Debdipta , Gogtay Nithya , Goel Tejusv , Konwar Mahanjit
Published: August 2021

Background:

The Black-Box Warning (BBW) is the most serious warning that US-FDA
can ask for on a drug’s labelling. BBWs represent key safety concerns uncovered either during
dossier review or post-approval. We have conducted the present study with the primary objective
of assessing BBWs issued by the US-FDA.

Methods:

BBWs were identified on US-FDA’s website from 1st January 2015 to 31st December,
2019. Prescribing information was used to identify and characterize BBWs into new and minor/major
updates on a previous BBW. The therapeutic class of the drug, nature [Biological/New Molecular
entity (NME)], formulation type, expected duration of use, along with the year of first approval
of the molecule with BBWs were evaluated.

Results:

A total of n = 167 BBWs were issued by the FDA of which 53 (31.7%) had major updates,
57(34.1%) had minor updates and 57(34.1%) were new BBWs. A total of 137(82%) of BBWs
were with NME’s whereas 30(18%) were with biologics. Drugs for neurology 40(25.5%)had
the highest number of BBWs, followed by oncology 38(24.2%). Among the type of BBWs, cardiovascular
risk 31 (15%) were the highest.

Conclusion:

Practicing physicians need to understand that benefit-risk of a drug is dynamic and
keep abreast of new data related to it.
Therapeutic Potential of Adipose-derived Stem Cells in the Treatment of
Pulmonary Diseases
Authors: Abdul Halim Nur Shuhaidatul Sarmiza , Yahaya Badrul Hisham , Lian Jie
Published: August 2021

:

Stem cells derived from adipose tissues (ADSCs) have emerged as an ideal candidate
for various models of respiratory diseases, including asthma, chronic obstructive pulmonary disease
(COPD), and acute respiratory distress syndrome. ADSCs have qualities that may make them
better suited for treating inflammatory lung diseases than other MSCs. ADSCs show a lower senescence
ratio, higher proliferative capacity and stability in terms of their genetic and morphology during
long-term culture over bone marrow-derived mesenchymal stem cells (BMMSCs). With enhanced
research methodologies, the beneficial benefits of ADSCs appear to be restricted to their capacity
to engraft, differentiate, and be connected to trophic factor secretion. These trophic factors
influence treatment and regenerative results in a variety of lung inflammatory disorders. Taken together,
these particular qualities of ADSCs make them significantly relevant for clinical applications.
This article discusses a recent advance of ADSCs biology and their translational application,
emphasizing their anti-inflammatory, immunomodulatory and regenerative properties, particularly
on lung inflammatory diseases. Besides, the relevant advancements made in the field, the regulatory
aspects, and other challenges and obstacles will be highlighted.
Hematological Consequences of Valproic Acid in Pediatric Patients: A Systematic Review with a Mechanistic Approach
Authors: Riahi-Zanjani Bamdad , Delirrad Mohammad , Fazeli-Bakhtiyari Rana , Sadeghi Mahood , Zare-Zardini Hadi , Jafari Abbas , Ghorani-Azam Adel
Published: August 2021

Purpose:

Although Valproate (VPA) has several advantages in controlling seizures, it may cause serious hematological consequences. Hematotoxicity of VPA is particularly important in pediatrics because patients at this age are at a growing risk of leukemia. For a conclusive agreement about the toxicity of VPA, in this study, we systematically reviewed the literature in which the hematological consequences of VPA had been emphasized.

Methods:

A systematic literature search was performed in June 2021 on electronic databases to find original research on the association between VPA therapy and hematotoxicity in pediatric patients. For this purpose, the following search terms “hematotoxicity”, “valproic acid” and “pediatrics” with different spellings and similar terms, were searched in the title, keywords, and abstracts of articles. The data were collected and used for qualitative data description.

Results:

A total of 36 relevant articles with an overall 1381 study population were included. The results showed that VPA could cause severe hematotoxicity in children even at therapeutic doses. Neutropenia, thrombocytopenia, and bone marrow depression are the most common complications associated with VPA therapy. Also, findings showed that after discontinuation of VPA and starting other antiepileptic drugs or reducing the administered VPA dose, hematologic damages were entirely resolved, and all the hematological parameters improved during two weeks.

Conclusions:

This review showed that VPA therapy could cause hematotoxicity in children; hence, it is recommended to monitor hematological indices during VPA therapy. Also, according to the suggested mechanistic pathways of VPA side effects, a combination of VPA with antioxidants may reduce hematological side effects.
Does Disease Activity Influence the Levels of Uric Acid in Psoriatic Arthritis?
Authors: Chu Bruna Burko Rocha , Pereira da Cunha João Pedro Villela Veiga , Marcon João Matheus Tussolini , de Arruda Prado Letícia Eduarda , Rosa Felipe Luis Silva , Leitão Julia Miguel , Thomaz Ana Cláudia , Kowalski Sérgio Cândido , Azevedo Valderílio Feijó
Published: August 2021

Background:

Hyperuricemia is not only associated with the development of gout but also with renal and vascular dysfunction. The prevalence of this condition has already been studied in psoriasis, but there are a few studies that have been carried out in psoriatic arthritis (PsA). Some studies have shown an association with metabolic syndrome, while others with the extent of cutaneous involvement, but there are no studies that have evaluated the disease activity with compound indexes.

Objective:

The aim of the study was to determine if disease activity, measured by different composite scores, influences the levels of uric acid.

Method:

This was a cross-sectional, observational study, which included 52 PsA patients. Clinical assessments included dactylitis, tender and swollen joint counts, Psoriasis Area and Severity Index, Leeds Enthesis Index, Minimal Disease Activity and Disease Activity for Psoriatic Arthritis. Hyperuricemia was defined as serum uric acid levels ≥ 6mg/dL in females and ≥ 7mg/dL in males.

Results:

Among the 52 included patients, 55.76% were female. The mean age was 54.9 ± 11.6 years. Hyperuricemia occurred in 26.92%. Demographic data, diet, comorbidities and medication were similar between patients with and without hyperuricemia. Patients with hyperuricemia had higher waist circumference (p <0.0046). There was no difference in disease activity between groups, either in the isolated items or in the composite indexes. There was a significant difference in uric acid levels according to the classification of chronic kidney disease by estimated glomerular filtration rate (p=0.0016). Individuals using leflunomide had significantly lower levels of uric acid than those who were not using (p=0.0071).

Conclusion:

This study supports the notion that, in PsA, hyperuricemia is more related to metabolic factors than to disease activity.
Ontologias bibliográficas e Web Semântica: limitações e propostas de investigação
Authors: Patrício Helena Simões , Cordeiro Maria Inês , Ramos Pedro Nogueira
Published: August 2021

The literature on bibliographic data and ontologies on the Semantic Webidentifies problems, not in terms of data instances or their publicationin isolated sets, but regarding the ontologies that describe the underlying concepts, impacting on the quality of semantic interoperability and in sharing ontologies between systems.This paper elaborates on the adequacy of conceptual models and the limitations of FRBR -Functional Requirements for Bibliographic Records (IFLA, 1998, 2018)1to the Semantic Web; the absence of a common conceptual framework; the insufficiency of semantic mechanisms; the low and deficient reuse of external vocabularies; and the inadequacy of mapping methodologies being applied.A research project is presented proposing a solution to the semantic problems in sharing ontologies, through the creation of a conceptual reference model and a reference ontology as a high level mechanism for semantic relations and data validation using SHACL -Shapes Constraint Language (KNUBLAUCH e KONTOKOSTAS, 2017).
Cartuns e Caretas objetificação, representação visual e informacional da mulher em uma revista de humor no início do século XX no Brasil
Authors: Oliveira Alessandra Nunes de , Castro Jetur Lima de , Santi Cecília Abrahão Nascimento , Nascimento Liliane Silva do
Published: August 2021

This research discusses the objectification relations, visual and informational representation of the woman identified in the cartoons found in Careta, a humor magazine in the beginning of the 20thcentury, in Brazil. The relationship between humor and the image of women is problematized through the cartoons in the columns of the Caretamagazine, which created discursive deformations of what would be the feminist movement through graphic humor, that is, through comic phrases and drawings. Based on the magazine's documentary narrative raised through the cartoons, it presents some discursive and visual representations placing women in a situation of subordination. Given that 'reading' a visual text is also an attempt to dissolve its fetishes, it is added that the cartoons represent cultural codes of a given period and show everyday or thought, as well as the vision of what was or is at the moment of looking. of readers. In our scope, Caretamagazine becomes an important source of information to discuss the image of women and the objectification that was addressed in this periodical in the beginning of the 20thcentury in Brazil. In the cartoons, there are satires of the image of the feminist and women's movement. Therefore, it is worth emphasizing that the theme addressed is relevant for understanding the political-social development in the issue of the emancipation of the image of women. In short, our analysis perceives the stereotype that exists in the “poorly formatted” discourse of Caretamagazine, that influenced ways of thinking and acting according to the relationship of aesthetic standards of what would be the ideal of women and the image of the feminist movement, confronting them from yesterday to today.
A Gestão da Informação como facilitadora do empoderamento psicológico e da melhoria do desempenho profissional
Authors: Pinto Cláudia , Carvalho Milena , Martins Susana
Published: August 2021

Information is essential to the organizations. They structure and classify it based on their organization, functions and activities, that is, based on the document production, the information flows between departments, the safeguarding and proof that this information constitutes. At Goweb Agency, Lda., most documents existed only for quality certification purposes. In order to improve information management in the organization, all documents were organized in a valid, intuitive way, based on the employees' information needs. By incorporating them in the routine tasks of daily life and encouraging their use, creating and adapting the sharing and management of information in the company's activities, there was a decrease in internal tension between employees, an increase in their level of satisfaction, their efficiency and effectiveness and a growing satisfaction of the company's customers, due to the performance and quality of the delivered work.
Dinamika Konflik Anti-Extradition Law Amendment Bill (ELAB) di Hong Kong Tahun 2019
Authors: Febrianti Soehartono Amelia , Noviryani Mely
Published: August 2021

The Conflict of Anti-Extradition Law Amendment Bill (ELAB) in Hong Kong did not appear out of thin air. It was instigated by a Pro-Democracy group to challenge the amendment bill proposed by the government. The conflict escalated when other internal and external actors like the United States expressed their support for the Pro-Democracy group to fight against the Amendment Bill. Using the conflict dynamics approach to examine the process of ELAB conflict, this article analyzes the process through three elements that include internal actors, external parties, and clashes between the Chinese and Hong Kongese in terms of their sociopolitical values. Finally, this research shows that the Hong Kong ELAB conflict had escalated and intensified even more due to the dynamics between these three elements.
Buruh Migran dan Human Trafficking: Studi Tentang Peningkatan Perdagangan Manusia dari Indonesia ke Malaysia
Authors: Monique Pricillia , Amalia Puspamawarni Vita
Published: August 2021

Human trafficking is a serious Transnational Organized Crime (TOC) faced by countries globally, including Indonesia and its neighbor, Malaysia. Both countries are categorized as tier 2 in the Palermo Protocol watchlist for their ineffective implementation of national laws and regulations to prevent or stop human trafficking. While Indonesia becomes the source country for human trafficking, Malaysia is the receiving country with the most Indonesian victims of human trafficking. There has been an increasing number of cases in 2014-2016. This paper aims to answer the main research question: what has caused the increase of human trafficking cases between Indonesia and Malaysia within this period? While internal factors from the source country influence human trafficking, external and personal factors contribute to the cases.
Strategi Keamanan Maritim Indonesia terhadap Maritime Piracy di Laut Sulu Tahun 2016
Authors: Laksmi Saraswati Ayu , Desy Arya Pinatih Ni Komang
Published: August 2021

The Sulu Sea, one of Indonesia's seas located in the strategic area of ALKI II (Indonesian Archipelagic Sea Lane), directly borders Malaysia and the Philippines. As a busy trade route, the sea is also vulnerable to threats such as maritime piracy. This research aims to see Indonesia's maritime security strategy in the Sulu Sea over maritime piracy cases in the area during 2016. In this research, the writer uses the Maritime Security concept proposed by Chris Rahman to explain Indonesia's maritime security strategy in the Sulu Sea. The author using three variables, including (1) security of the sea itself: conservation and protection; (2) ocean governance; (3) maritime border protection; (4) military activities at sea, and (5) security regulation of the transport marine system in their correlation with each other. The author then concludes that out of five variables, only two are suitable and effective for implementing piracies in the Sulu Sea, namely maritime border protection and military activities at sea.
Sexual Gender-Based Violence in Greek Refugees Camp
Authors: Nadhifa Khairunnisa , Fahadayna Adhi Cahya
Published: August 2021

In 2015 the European Migrant Crisis pushed Europe to a new dimension of issues and problems. With the mass of people migrating into the region, Greece became one of the front-line countries to face the crisis by hosting the country's high refugee population. Due to their incapability to adjust and respond according to the needs and situation of the crisis, other issues rise within Greek settlements among refugees themselves where violence came into existence. Sexual and Gender-Based Violence (SGBV) appears in the refugee population that targeted women refugees living in the Greek camps. To know exactly why the causes of SGBV to happen in the first place against women refugees can be known through the effort of the Heise Model by Lori Michau to seek the root problems of the causes that drive the reason SGBV to exist within risky situations such as refugee camps. Through this Heise Model, the author seeks the causes of why SGBV happened in Greek refugee camps in 2015-2018 in covering four levels of societal, community, interpersonal, and individual.
Problematika Pendidikan di Perbatasan: Studi Kasus Pendidikan Dasar bagi Anak Pekerja Migran Indonesia (PMI) di Negara Bahagian Sarawak, Malaysia
Authors: Sulistya Handoyo Budi , Triarda Reza
Published: August 2021

Education as one of the basic rights or fundamental rights that everyone must own has been discussed since 1948 in the Universal Declaration of Human Rights. Primary education becomes important later because education is a strategic aspect of human life. Malaysia, as one of the destination countries of Indonesian migrant workers as a place to work. From the data of 2.7 million people spread throughout the territory of Malaysia. The problems that arise are not only in the administration of the workers but also the children they bring to work there. It becomes a dilemma because the government cannot go down directly because of obstacles such as national borders and the applicable rules. The Transnational Public-Private Partnership, which is then carried out between the two countries and a third party, private then, can fulfill that education. CLC or Community Learning Center is a manifestation of this form of public-private collaboration. In this case, the private sector's involvement is significant in fulfilling the education of Indonesian migrant worker children in the Sarawak region. To date, 62 CLCs provide access to education for 1,658 Indonesian children. With local teachers/tutors who are Indonesian citizens, the company recruits to teach with a minimum high school / vocational certificate. Until June 2019, there were 94 Pamong Teachers in the Sarawak CLC, and Bina Teachers were teachers sent by the Indonesian Government (Kemendikbud RI) to teach at the CLC. As of June 2019, there were 23 Bina Teachers in the Sarawak CLC.
Transnational Drug Trafficking: Studi Kasus Peningkatan Peredaran Narkotika di Bangladesh
Authors: Arif Ramadhan Bayu , Zulhair Achsin Muhammad
Published: August 2021

Drug trafficking is one of the numerous acts of transnational criminal organizations (TOC). Bangladesh upon the course of 2015- 2017, had suffered from the intense drug flow, especially from the type of Yaba/amphetamine-type stimulant (ATS) in which peaked itself in 2015 by 211,2% percentage comparing to the previous years according to Drug Narcotics Control (DNC) reports and various media outlets. These flows were suspiciously running from the neighborhood country from Bangladesh, Myanmar, due to the unavailability of domestic yaba/ATS producers within Bangladesh. Contradict to the prevailing course of domestic anti-drug law in Bangladesh as embodied within the Drug Narcotics Act 2002, which tries to curb and prohibit whole activities regarding drug trafficking or flow. Therefore the writer was curious to conduct further research to examine the factors available to influence the intensity of drug trafficking and flow in Bangladesh upon 2015-2017.
Rivalitas Negara Adidaya di Ruang Angkasa
Authors: Marsaulina Situmorang Veronica
Published: August 2021

International relations not only focused on cooperative relations but also rivalry relationships that characterize the existence of competition to create progress in the global system, whose primary goal is to prioritize the domestic interests of each competing state actor. With all the demands for existing renewal, the modern world makes every country compete fiercely to show self-esteem as a great country. After the cold war, the source of world power has grown from being bipolar, namely the United States and the Soviet Union, to becoming multipolar. This paper will focus on the competition between the United States, and one of the countries predicted to become a new center of power in the international world, namely China. China's rapid progress in various fields has made it even more calculated and has become a new threat to the US as a superpower. Not only the economy and defense, now China's progress is starting to develop in the field of space control, and this is increasingly making the US-China rivalry relationship even more complex. This paper will be explained with a descriptive-qualitative research method that tries to describe in-depth and narrate the form of competition between the United States and China in the control of space and its astropolitics strategy.
Strategi Pemerintah Taiwan dalam Meningkatkan Ekspor Agrikultur melalui Economic Cooperation Framework Agreement (ECFA)
Authors: Pramesti Azalia Ayu , Purbantina Adiasri Putri
Published: August 2021

The relationship between China and Taiwan since separating in 1949 continues to fluctuate, particularly with the One China Policy. However, despite the political tension between the two, they have close bilateral economic ties relations, where China is Taiwan's largest trading partner. China and Taiwan signed an agreement entitled "Cross-Straits Economic Cooperation Framework Agreement" (ECFA) in 2010. The ECFA challenges Taiwan's agricultural sector. This paper evaluates how the Taiwanese government response to boost the competitiveness of their agricultural exports through three channels: 1) foreign policies, 2) trade regulations, and 3) supports to domestic firms.
Jakość życia kobiet po mastektomii
Authors:   Państwowa Uczelnia Zawodowa we Włocławku, Rybka Mariola , Ziółkowska Małgorzata ,   Wojewódzki Szpital Specjalistyczny im. Błogosławionego księdza Jerzego Popiełuszki we Włocławku
Published: August 2021

Introduction. Amazons is a group of women who are extremely brave and valiant in their social organization, who support each other against the heavy adversary that has put their lives in their way- breast cancer. The activities of associations facilitate adaptation to the new health situation of these women. An indispensable aspect of women after a mastectomy is their quality of life. The concept of quality of life is a multidimensional term covering every sphere of human life at every stage. Aim. The aim of the work was to assess the quality of life of women after mas-tectomies associated with the Amazon group. Material and methods. The study examined 103 women aged ≥ 20. More than three quarters of respondents lived in urban areas and one in three women lived in rural areas. The WHOQOL-BREF questionnaire is used to assess the quality of life and is a standardised tool for assessing the quality of life of both healthy and sick people. Results. Women after mastectomy affiliated with the Amazon club accept their appearance and health, which translates into an overall quality of life. Conclusions. Patients after the sparing procedure assess their quality of life at the highest level, while women after bilateral mastectomy at the lowest level. The extent of the support provided by loved ones has a significant impact on self-assessment in terms of quality of life satisfaction. Awareness of cancer negatively affects the mental sphere. Active professional persons after mastec-tomy were given the opportunity to return to work, which positively affected the quality of life.
Pendekatan Scientific dalam Implementasi Kurikulum 2013 bagi Peserta Didik dengan Hambatan Intelektual
Authors: Prabawati Wening , Mumpuniarti Mumpuniarti
Published: August 2021

Artikel ini membahas tentang penggunaan pendekatan scientific dalam pelaksanaan kurikulum 2013 bagi anak dengan hambatan intelektual. Jenis penelitian ini adalah penelitian deskriptif. Subjek dari penelitian ini adalah dua sekolah luar biasa di Kota Yogyakarta. Teknik pengumpula data yang digunakan adalah wawancara, observasi, dan dokumentasi. Instrumen berisi pertanyaan dan pernyataan yang digunakan untuk mengetahui penggunaan pendekatan scientfic dalam kegiatan pembelajaran. Analisis data yang digunakan adalah analisis deskriptif. Hasil penelitian menunjukkan bahwa pembelajaran bagi anak dengan hambatan intelektual terdiri dari aktivitas menanya, mengamati, mengumpulkan informasi/mencoba, menalar dan mengkomunikasikan. Saran yang dapat diberikan dari penelitian ini adalah pendidik perlu mencoba banyak pendekatan dalam pembelajaran bagi anak dengan hambatan intelektual agar mereka dapat lebih memahami materi yang mereka pelajari.
Pengaruh Metode Pembelajaran Musikal bagi Kemampuan Kognitif Anak Autis di SLB Negeri Manekat Niki-Niki
Authors: Njudang Erli , Ranimpi Yulius Yusak , Prayitno Iky Sumarthina Putri
Published: August 2021

Cognitive ability is one of the important aspects for individuals who need to be equipped and developed since childhood, including children with autism. Children with autism have difficulty receiving and understanding learning material and information received in class because they have problems with cognitive abilities. Therefore, we need a new learning method that is expected to help children with autism in developing their cognitive abilities to support learning activities in the classroom. This research aimed to determine the effect of musical learning methods on the cognitive abilities of autistic students. The subjects were 3 autistic students who experience obstacles in composing language in communication, difficulty of concentrating, and behaving repetitively in SLB Negeri Manekat Niki-Niki. The research method used was pre-experimental design quantitative with one group pretest-posttest design. The data analysis technique used was descriptive statistical analysis. The results showed that musical learning methods were effective and had an effect on the cognitive abilities of autistic students who had limitations in concentrating and repetitive behavior, but were not yet effective enough for autistic students who had language development disorders in communication.
Use of magnetic sand to improving writing ability for autistic children in special education laboratories
Authors: Abadi Reza Febri
Published: August 2021

Abstract: This research is motivated by the availability of an autistic have not been able to write. One of the learning media that is assumed to be able to improve the writing ability of the child is magneticsand. The purpose of this research is to find out the use of magnetic sand to improve writing skills in children with autism. This research was an experiment by using the Single Subject Research (SSR) approach and A – B – A design was as the design of this research. The researcher collected the data by using observation and documentation and the data was analyzed by using in condition and among condition analysis. This research conducted in a month by 4 – 8- 4 (A1 – B – A2) section and by behavior target which made line shapes and vocal letters. The data was obtained on behavior target 1 was 40 % in baseline phase 1 (A1,) 80% in intervention phase, and 71,25 % in the baseline and behavior target 2 was 35 % in baseline phase 1 (A1,),  80 % in intervention phase and 71,25 % in the baseline. Thus, it can be concluded that the use of magnetic sand as a media can improve student’s writing ability.
Pengalaman Orang Tua Anak Berkebutuhan Khusus Mengenai Pembelajaran daring selama Pandemi COVID-19
Authors: Permata Sari Diana , Paska Stephani
Published: August 2021

Pandemi COVID-19 mempengaruhi berbagai aspek kehidupan manusia. Salah satunya adalah aspek pendidikan. Penelitian kualitatif ini bertujuan untuk menggali perspektif para orang tua terhadap metode pembelajaran daring (dalam jaringan/online) untuk anak berkebutuhan khusus (ABK) selama masa pandemi COVID-19. Pengambilan data dilakukan dengan metode survei pertanyaan terbuka pada google form kemudian dilanjutkan dengan wawancara melalui aplikasi Whatsapp. Responden adalah 43 orang tua dari ABK yang berada Jakarta, Jawa Barat, Jawa Tengah, Yogyakarta serta Jawa Timur.  Berdasarkan hasil analisis tematik induktif data ditemukan bahwa orang tua sebagai pendamping anak yang utama selama pembelajaran daring merasa bahwa pembelajaran daring tidak hanya memberikan pengalaman secara negatif bagi mereka namun juga memberikan pengalaman positif bagi para orang tua dan juga anak mereka. Pengalaman positif yang muncul adalah adanya komunikasi dan relasi yang terbangun lebih baik dari sebelumnya antara orang tua dengan guru. Kedua, adanya perkembangan kemampuan anak yang positif selama belajar di rumah seperti kemandirian. Terakhir, orang tua merasa kemampuan penguasaan materi maupun teknologi bertambah dengan adanya sistem pembelajaran daring. Sedangkan tema terkait pegnalaman negatif dari pembelajaran secara daring adalah adanya kebutuhan khusus tertentu yang mengalami kesulitan dengan penggunaan media daring untuk pembelajaran. Lalu, kendala kuota serta keterbatasan perangkat elektronik yang digunakan merupakan pengalaman negatif yang banyak ditemui oleh para guru serta orang tua. Beberapa orang tua menyimpulkan jika pembelajaran daring tidak cocok untuk disabilitas tertentu.
A Patient Decision Aid for Anticoagulation Therapy in Patients With Nonvalvular Atrial Fibrillation: Development and Pilot Study
Authors: de Castro Kim Paul , Chiu Harold Henrison , De Leon-Yao Ronna Cheska , Almelor-Sembrana Lorraine , Dans Antonio Miguel
Published: August 2021

Background

Atrial fibrillation (AF) is one of the most common predisposing factors for ischemic stroke worldwide. Because of this, patients with AF are prescribed anticoagulant medications to decrease the risk. The availability of different options for oral anticoagulation makes it difficult for some patients to decide a preferred choice of medication. Clinical guidelines often recommend enhancing the decision-making process of patients by increasing their involvement in health decisions. In particular, the use of patient decision aids (PDAs) in patients with AF was associated with increased knowledge and increased likelihood of making a choice. However, the majority of available PDAs is from Western countries.

Objective

We aimed to develop and pilot test a PDA to help patients with nonvalvular AF choose an oral anticoagulant for stroke prevention in the local setting. Outcomes were (1) reduction in patient decisional conflict, (2) improvement in patient knowledge, and (3) patient and physician acceptability.

Methods

We followed the International Patient Decision Aid Standards (IPDAS) to develop a mobile app–based PDA for anticoagulation therapy in patients with nonvalvular AF. Focus group discussions identified decisional needs, which were subsequently incorporated into the PDA to compare choices for anticoagulation. Based on recommendations, the prototype PDA was rendered by at least 30 patients and 30 physicians. Decisional conflict and patient knowledge were tested before and after the PDA was implemented. Patient acceptability and physician acceptability were measured after each encounter.

Results

Anticoagulant options were compared by the PDA using three factors that were identified (impact on stroke and bleeding risk, and price). The comparisons were presented as tables and graphs. The prototype PDA was rendered by 30 doctors and 37 patients for pilot testing. The mean duration of the encounters was 15 minutes. The decisional conflict score reduced by 35 points (100-point scale; P<.001). The AF knowledge score improved from 10 to 15 (P<.001). The PDA was acceptable for both patients and doctors.

Conclusions

Our study showed that an app-based PDA for anticoagulation therapy in patients with nonvalvular AF (1) reduced patient decisional conflict, (2) improved patient knowledge, and (3) was acceptable to patients and physicians. A PDA is potentially acceptable and useful in our setting. A randomized controlled trial is warranted to test its effectiveness compared to usual care. PDAs for other conditions should also be developed.
Areas of Interest and Attitudes Toward Antiobesity Drugs: Thematic and Quantitative Analysis Using Twitter
Authors: Alvarez-Mon Miguel Angel , Llavero-Valero Maria , Asunsolo del Barco Angel , Zaragozá Cristina , Ortega Miguel A , Lahera Guillermo , Quintero Javier , Alvarez-Mon Melchor
Published: August 2021

Background

Antiobesity drugs are prescribed for the treatment of obesity in conjunction with healthy eating, physical activity, and behavior modification. However, poor adherence rates have been reported. Attitudes or beliefs toward medications are important to ascertain because they may be associated with patient behavior. The analysis of tweets has become a tool for health research.

Objective

The aim of this study is to investigate the content and key metrics of tweets referring to antiobesity drugs.

Methods

In this observational quantitative and qualitative study, we focused on tweets containing hashtags related to antiobesity drugs between September 20, 2019, and October 31, 2019. Tweets were first classified according to whether they described medical issues or not. Tweets with medical content were classified according to the topic they referred to: side effects, efficacy, or adherence. We additionally rated it as positive or negative. Furthermore, we classified any links included within a tweet as either scientific or nonscientific. Finally, the number of retweets generated as well as the dissemination and sentiment score obtained by the antiobesity drugs analyzed were also measured.

Results

We analyzed a total of 2045 tweets, 945 of which were excluded according to the criteria of the study. Finally, 320 out of the 1,100 remaining tweets were also excluded because their content, although related to drugs for obesity treatment, did not address the efficacy, side effects, or adherence to medication. Liraglutide and semaglutide accumulated the majority of tweets (682/780, 87.4%). Notably, the content that generated the highest frequency of tweets was related to treatment efficacy, with liraglutide-, semaglutide-, and lorcaserin-related tweets accumulating the highest proportion of positive consideration. We found the highest percentages of tweets with scientific links in those posts related to liraglutide and semaglutide. Semaglutide-related tweets obtained the highest probability of likes and were the most disseminated within the Twitter community.

Conclusions

This analysis of posted tweets related to antiobesity drugs shows that the interest, beliefs, and experiences regarding these pharmacological treatments are heterogeneous. The efficacy of the treatment accounts for the majority of interest among Twitter users.
Self-directed Technology-Based Therapeutic Methods for Adult Patients Receiving Mental Health Services: Systematic Review
Authors: Saad Anthony , Bruno Deanna , Camara Bettina , D’Agostino Josephine , Bolea-Alamanac Blanca
Published: August 2021

Background

Technological interventions used to treat illnesses and promote health are grouped under the umbrella term of digital therapeutics. The use of digital therapeutics is becoming increasingly common in mental health. Although many technologies are currently being implemented, research supporting their usability, efficacy, and risk requires further examination, especially for those interventions that can be used without support.

Objective

This review aims to identify the evidence-based, self-directed, technology-based methods of care that can be used in adult patients after they are discharged from mental health services. The interventions reviewed are automated with no human input required (either at the patient’s or at the technology’s end), so the patients can implement them without any support.

Methods

A systematic review was conducted according to the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) and PROSPERO (International Prospective Register of Systematic Reviews) guidelines in 3 databases: PubMed, Web of Science, and OVID. The inclusion criteria were self-directed, automated, and technology-based interventions related to mental health, primarily for adults, having a solid evaluation process. The interventions had to be self-directed, in that the participants could use the technology without any external guidance.

Results

We identified 36 papers that met the inclusion criteria: 26 randomized controlled trials, 9 nonrandomized controlled trial quantitative studies, and 1 qualitative study. The technologies used included websites, automated text messaging, phone apps, videos, computer software, and integrated voice response. There were 22 studies focused on internet-based cognitive behavioral therapies as a therapeutic paradigm compared with the waitlist, web-based human-delivered therapy, and other interventions. Among these studies, 14 used paradigms other than the internet-based cognitive behavioral therapy. Of the 8 studies comparing guided and unguided digital care, 3 showed no differences, 3 favored guided interventions, and 2 favored unguided interventions. The research also showed that dropout rates were as high as 80%, citing potential problems with the acceptability of the suggested technologies.

Conclusions

There is limited research on the efficacy and suitability of self-directed technology-based care options for mental health. Digital technologies have the potential to bridge the gap between ambulatory care and independent living. However, these interventions may need to be developed collaboratively with the users to encourage their acceptability and to avoid high dropout rates.
Gambian Women’s Struggles through Collective Action
Authors: Janneh Fatou
Published: August 2021

Women have a long history of organizing collective action in The Gambia. Between the 1970s to the 1990s, they were instrumental?to The Gambia’s politics. Yet they?have?held no political power within its government. This paper argues that, since authorities failed to serve women’s interests, Gambian women resorted to using collective action to overcome their challenges through kafoolu and kompins [women’s grassroots organizations] operating in the rural and urban areas. They shifted their efforts towards organizations that focused on social and political change. These women’s organizations grew significantly as they helped women to promote social and economic empowerment. The women cultivated political patronage with male political leaders to achieve their goals. Political leaders who needed popular support to buttress their political power under the new republican government cash in patronage. Thus, this study relies on primary data from oral interviews. Secondary sources such as academic journals, books, and policy reports provide context to the study.
Peningkatan kualitas pembelajaran melalui lesson study learning community pada materi “waktu 24 jam” di Sekolah Dasar
Authors: Wahyuni Sri , Eko Susetyarini Roro , Prihanta Wahyu , Yuliana Firdiani
Published: August 2021

The main task of the teacher in the learning process is to lead participants to achieve their learning goals. Thus, teachers are required to always improve the quality of their learning, one of which is through the Lesson Study Learning Community (LS-LC). The purpose of this research is to describe the implementation of the Lesson Study Learning Community in SD (Sekolah Dasar-Primary School) Junrejo I, in “the 24-hour clock” material. This qualitative research employed a single case study and explained it naturally. The respondents were one teacher and 28-second graders. There were three stages in the implementation of lesson study, namely: plan, do and see. The data collection technique were using documentation and unstructured interview. The data were analyzed in a quantitative and qualitative description. The findings in the planned activity were the collaboration of teachers and lecturers in innovating and creating chapter and lesson design of “the 24-hour clock” material, considering the characteristic of students. In the open class (do the activity), the students were conducting discussions and observations. During learning, the students were comparing digital and non-digital clocks while lecturers and teachers were observing the learning process. In the seen activity, the observation result from teachers and lecturers were revealed. The implementation of Lesson Study Learning Community in grade II SD Junrejo I, on the material "24 hour time" had been going well. But the results shown that students were able to understand the material as much as 60%, students were able to collaborate in groups 45%, student’s expression was happy, excited, motivating, and cheerful, as much as 90%. It needs replanning with changes in seating arrangements, group arrangements, and group members
Implementasi pendidikan karakter berbasis kearifan lokal
Authors: Faiz Aiman , Soleh Bukhori
Published: August 2021

The integration of local wisdom, such as batik and glass painting, and other Cirebon culture in general courses (Mata Kuliah Umum/ MKU) may be an interesting alternative learning approach. This research aims to describe the implementation of character education models based on local cultural wisdom such as the ability to design batik, glass paintings, and the introduction of other typical Cirebon cultures in MKU. It employed a descriptive qualitative approach to explore naturally visible phenomena. The subjects of this research were 7th semester students of Primary School Teacher Education (Pendidikan Guru Sekolah Dasar/ PGSD), University of Muhammadiyah Cirebon (UMC), class of 2016. The data were obtained from observations and interviews involving 15 respondents consisting of students, lecturers, and the Head of PGSD UMC. The results showed that MKU increased students' knowledge and skills outside the field of education as the students were enthusiastically embraced the Cirebon culture given in MKU. It can be concluded that MKU based on local wisdom was able to hone the skills of PGSD UMC students in improving their affective, psychomotor, and cognitive abilities. Thus, students were prepared to have holistic abilities that are compatible with the challenges of a new life.
Gim edukasi berbasis android sebagai optimasi pembelajaran daring di masa pandemi Covid 19
Authors: Hasanah Fitria Nur , Taurusta Cindy , Sri Untari Rahmania , Nurul Hidayah Dini , Rindiani Rindiani
Published: August 2021

The innovation in Information and Communication Technology (ICT)-based learning media is a critical learning alternative during the Covid-19 pandemic. One of the ICT-based learning media is android-based educational games. This research aims to develop android-based educational games on object-oriented programming (OOP) courses for Information Technology Education (ITE) students and to find out the feasibility of this product in online learning optimization. This research employed Research and Development (R&D) with Analysis, Design, Develop, Implement, Evaluate (ADDIE) development model. Participants of this research were the fifth-semester ITE students. Questionnaires validated by learning material and media experts were tested on limited groups before being distributed to the participants. Results show that the feasibility level on the material content aspect is 93.2%, and the language aspect is 93.3%, referring to very feasible criteria. The feasibility level on the content quality is 90%, the design and audio aspects are 95%, and interaction and feedback are 93.75%, referring to very feasible criteria. The trial results of the limited group are 96% with very feasible criteria. These findings indicate that android-based educational games are feasible and can be implemented in the learning process.
Editorial: New challenges and opportunities in strategic decision making
Authors: Situm Mario
Published: August 2021

We are pleased to present the recent issue of the journal “Corporate and Business Strategy Review”. In this issue, current findings from the research are presented, which will support researchers with ideas for future work and provide managers and consultants with resources to support the development of solutions and assistance in decision-making.