bluuebunny/crossref_metadata_2025 huggingface dataset:
LENDUTAN STRUKTUR TWIN BOOM PESAWAT TERBANG NIR AWAK LSU-05 PADA SAAT MENERIMA BEBAN TERBANG (DEFLECTION OF LSU-05 UAV TWIN BOOM STRUCTURE ON RECIEVING THE FLIGHT LOAD)
Authors: Bintoro Atik
Published: February 2018

The twin-boom structure is a component of LSU-5 unmanned aireal vehicle (UAV) construction wich was produced by Aeronautic Technology Center of LAPAN. This structure serves as a stabilizer UAV movements. In operations, the structure will recieve flight load which could result as the structure deflection. Through analytical methods involving the mission, dimensions and configuration of the structure of the twin-boom LSU 05 UAV, has done research to determine the extent of the ability of the structure in the fligth load, so the resulting deflection. From this research it was known that at flighting during 130 minutes, starting from take off the beginning of the flight until  cruising with maximum velocity in 130 km/h, the maximum deflection that occurred in the structure only reaches 5.593 x 10-6 m, with a safety factor of 1.3, it’s means that the structure was relatively save. While at the landing on a relatively save was velocity below 14 km/h. If landing at the velocity exceeding 20 km/h can be believed that the twin-boom structure suffered severe damage, because the stress occurs already exceeded from 650 MPa as the yield strenght of e-glass composite materials. Abstrak:Struktur twin boom merupakan salah satu komponen konstruksi pesawat terbang nir awak LSU-05 hasil karya Pusat Teknologi Penerbangan - LAPAN. Struktur ini berfungsi sebagai penyetabil gerakan pesawat. Dalam operasionalnya, struktur menerima beban terbang yang dapat mengakibatkan timbulnya lendutan. Melalui metode analitis yang melibatkan misi, dimensi dan konfigurasi struktur twin boom pesawat LSU-05, telah dilakukan penelitian untuk mengetahui sejauh mana kemampuan struktur dalam menerima beban terbang, sehingga mengakibatkan lendutan tersebut. Dari penelitian ini diketahui bahwa pada saat penerbangan, selama 130 menit mulai dari tinggal landas di awal penerbangan sampai dengan terbang jelajah pada kecepatan maksimal 130 km/jam, lendutan maksimal yang terjadi pada struktur hanya mencapai 5,593 x 10-6 m, dengan faktor keamanan sebesar 1,3 berarti struktur relatif aman. Sedangkan untuk pendaratan, kecepatan yang relatif aman dapat dilakukan di bawah 14 km/jam. Jika mendarat pada kecepatan melebihi 20 km/jam, struktur twin boom tersebut mengalami kerusakan parah, karena tegangan yang terjadi sudah melebihi 650 MPa sebagai tegangan ijin bahan struktur yakni komposit e-glass.
DEKOMPOSISI TERMAL PROPELAN KOMPOSIT BERBASIS AMONIUM PERKLORAT/HYDROXY TERMINATED POLYBUTADIENE (AP/HTPB)
Authors: Dewi Wiwiek Utami , Ismah Yulia Azatil
Published: February 2018

Thermal decomposition process of AP/HTPB solid propellant type RUM, 450 and 1220 were investigated by DTG60 (Differential Thermogravimetric) with operational parameters: temperature 30 – 400oC, nitrogen flow rate 50 ml/min, and heating rate 2.5 C/min. Thermal decomposition analysis will be the first step of decomposition kinetics research in determining life time of the propellant. TGA curve of propellant RUM was found to be two staged meanwhile the thermal decomposition of propellant 450 and 1220 has become one staged. The DTA curve/thermogram of propellant RUM show the formation of intermediate product before full-length decomposition. Unlike propellant RUM, DTA curves of propellant 450 and 1220 do not show the formation of intermediate product. Decomposition process of propellant 450 and 1220 accelerate by Al presence. The difference between AP modal on propellant 450 and 1220 show insignificance effect to the amount of decomposition energy consumption.  Abstrak Proses dekomposisi termal propelan padat AP/HTPB jenis RUM, 450 dan 1220 telah dianalisis menggunakan Differential Thermogravimetric 60 (DTG) dengan parameter operasi: suhu 30 - 400⁰C, atmosfer nitrogen berlaju alir 50 ml/menit, dan laju pemanasan 2,5⁰C/menit. Analisis dekomposisi termal adalah langkah awal penelitian kinetika dekomposisi propelan dalam menentukan life time propelan. Kurva TGA menunjukkan bahwa propelan RUM mengalami proses dekomposisi dua tahap sedangkan propelan 450 dan 1220 mengalami proses dekomposisi satu tahap. Kurva DTA/ termogram proses dekomposisi propelan RUM menunjukkan adanya pembentukan produk intermediate sebelum akhirnya terdekomposisi sempurna. Berbeda dengan propelan RUM, termogram propelan 450 dan 1220 tidak menunjukkan terbentuknya produk intermediate. Proses dekomposisi propelan 450 dan 1220 terakselerasi oleh keberadaan Al. Perbedaan modal AP pada propelan 450 dan 1220 ternyata tidak begitu berpengaruh pada nilai konsumsi energi proses dekomposisi.
KAJIAN EKSPERIMENTAL TENSILE PROPERTIES KOMPOSIT POLIESTER BERPENGUAT SERAT KARBON SEARAH HASIL MANUFAKTUR VACUUM INFUSION SEBAGAI MATERIAL STRUKTUR LSU
Authors: Abdurohman Kosim , Marta Aryandi
Published: February 2018

Vacuum infusion is a manufacturing method to improve mechanical properties of composite. Before apply this in LSU structure, it should be experimented using tensile test to know mechanical properties of the composite. Tensile test is an experimental to know tensile strength, modulus of elasticity, and failure modes of composite. Experimental process of CFRP composite using unidirectional carbon fiber and polyester matrix was done using vacuum infusion technology, strart from specimens preparation until testing steps. Manufacturing results gave the values of composite density and thickness; mass and volume fraction of fiber and matrix materials. Specimens and testing process are refer to ASTM D3039 tensile test standard for composite matrix polymers. The testing results showed 1011.67 MPa ultimate tensile strength, 59074.96 MPa modulus of elasticity, and SGV (long spliting, gage, various) failure mode . Abstrak Vacuum infusion merupakan salah satu metode manufaktur yang digunakan untuk meningkatkan sifat mekanik komposit. Untuk mengaplikasikan metode ini dalam pembuatan struktur LAPAN Surveillance UAV (LSU), perlu diketahui terlebih dahulu sifat mekanik dari komposit hasil metode ini secara eksperimen. Salah satu eksperimen yang dilakukan yaitu pengujian tarik untuk mendapatkan tensile strength, modulus elastisitas, dan failure mode yang terjadi pada komposit.Eksperimen dilakukan terhadap komposit CFRP menggunakan material serat karbon searah (UD) 0⁰ dan matriks poliester dibuat dengan metode vacuum infusion mulai dari tahap preparasi sampai tahap pengujian. Dari hasil manufaktur didapat nilai densitas dan ketebalan komposit serta fraksi massa dan fraksi volume material penyusun komposit. Spesimen dan proses pengujian mengikuti standar ASTM D3039 yang merupakan standar pengujian tarik untuk komposit dengan matriks polimer. Hasil pengujian menunjukkan nilai ultimate tensile strength 1011,67 MPa, modulus elastisitas 59074,96 MPa, dan failure mode SGV (Long Spliting, Gage, Various).
STRENGTHENING CONCRETE HOLLOW SECTION GIRDER BRIDGE USING POLYURETHANE-CEMENT MATERIAL (PART B)
Authors: Hussain Haleem
Published: February 2018

This paper presents experimental study to retrofitted reinforced concrete Hollow Section Bridge. The study was carried out on the White River Bridge structure (Bai xi da Qiao / China). The effect of retrofitting on stress and strain of beams at the critical section was studied. Evaluating the bridges girder after strengthening using new material called Polyurethane- Cement material (PUC) as an external material .This study present the strain and deflection before and after strengthening the bridge girders. The results has shown that the overall state of the bridge structural strengthening is in good condition. The enhancement was significant in stiffness of the bridge structure. Regarding to the results of static load test, the experimental values strain and deflection are less than theoretical values, indicating that the stiffness of the structure, overall deformation and integrity satisfy the designed and standard requirements and the working performance are in good condition, and flexure capacity has a certain surplus.
Upaya Mengoptimalkan Gerakan Literasi pada Ikatan Pelajar Muhammadiyah Kabupaten Banyumas
Authors: M Makhrus , Cahyani Putri Dwi
Published: February 2018

Kegiatan pelatihan penulisan kreatif kreatif dan publikasi dalam upaya mengoptimalkan gerakan literasi pada Pimpinan Daerah Ikatan Mahasiswa Muhammadiyah Kabupaten Banyumas bertujuan memberikan dorongan motivasi kepada pada kader dan pimpinan mengenai pentingnya optimalisasi dan kesadaran mengenai gerakan literasi, memberikan pemahaman dan wawasan yang komprehensif mengenai hal-hal yang berkaitan dengan penulisan kreatif dan publikasi, memberikan keterampilan/skill tentang penulisan kreatif dan publikasi.Program pelatihan ini diberikan kepada kader dan pimpinan Dewan Pimpinan Ikatan Pelajar Muhammadiyah Kabupaten Banyumas dengan menggunakan metode seminar, diskusi dan sharing. Harapan kegiatan ini agar para peserta dapat memahami, mengerti, dan mampu mempraktikkan menulis kreatif dalam berbagai bentuk tulisan yang peserta hasilkan, sehingga dapat memberikan dalam positif terhadap perkembangan organisasi melalui gerakan literasi.Adanya pelatihan pelatihan penulisan kreatif dalam upaya mengoptimalkan gerakan literasi pada Pimpinan Daerah Ikatan Mahasiswa Muhammadiyah Kabupaten Banyumas memiliki dampak penambahan wawasan mengenai teknik penulisan kreatif, hal tersebut dapat terlihat dari keinginan para kader dan untuk mempublikasikan tulisan dalam bentuk buku dan mengoptimalkan media sosial yang dimiliki sebagai sarana formal organisasi. Secara internal gerakan PD IPM Kabupaten Banyumas sudah memiliki tradisi keilmuan dan budaya literasi yang baik, hal tersebut dipengaruhi oleh corak dan kultur keilmuan gerakan IPM secara nasional yang sangat mendorong gerakan literasi di kalangan pelajar. Berdasarkan hasil evaluasi para peserta menyatakan puas dan berharap agar tindak lanjut kegiatan dalam beragam kegiatan formal dan khusus yang dilaksanakan oleh PD IPM Kabupaten Banyumas.
Pengaruh Faktor Budaya, Psikologi, Pelayanan, Promosi dan Pengetahuan tentang Produk terhadap Keputusan Nasabah Memilih BPRS di Banyumas
Authors: Nurlaeli Ida
Published: February 2018

Tujuan penulisan makalah ini adalah untuk mengetahui apakah faktor budaya, psikologis, pelayanan, promosi dan pengetahuan tentang produk berpengaruh terhadap keputusan nasabah dalam memilih bank syari’ah. Dari hasil uji validitas dan reliabilitas, nilai Cronbach Alpha sebesar 0,911> 0,6 maka dapat disimpulkan bahwa variabel tersebut adalah valid dan reliabel untuk mengukur pengaruh budaya, psikologis, pelayanan, promosi, pengetahuan tentang produk terhadap keputusan nasabah dalam memilih bank syari’ah.Hasil uji asumsi klasik, yang meliputi uji multikolinearitas dan uji heteroskedstisitas, bahwa hasil pengujian multikolinearitas, hasil perhitungan nilai tolerance tidak ada variabel independen yang memiliki nilai tolerance <0,10. Demikian juga dengan hasil perhitungan nilai VIF, dari variabel independen yang diuji tidak ada nilai VIF yang lebih dari 10, maka tidak ada multikolinearitas antara variabel independen dalam model regresi. Hasil pengujian heteroskedastisitas, Hasil grafik Scatterplot yang tersaji memperlihatkan bahwa titik-titik menyebar secara acak serta tersebar di atas maupun di bawah angka 0 pada sumbu y, serta tidak mempunyai pola yang jelas atau tidak membentuk suatu pola, maka tidak terjadi heteroskedastisitas pada model regresi, sehingga model regresi layak digunakan sebagai alat prediksi.Hasil uji hipotesis dengan regresi berganda, tingkat signifikan untuk variabel budaya sebesar 0,531>0,05, artinya variabel budaya secara parsial tidak berpengaruh nyata terhadap keputusan nasabah memilih bank syariah. Tingkat signifikasi variabel psikologi 0,824>0,05 yang berarti variabel psikologis secara parsial tidak berpengaruh nyata terhadap keputusan nasabah memilih bank syariah. Tingkat signifikasin variabel pelayanan 0,000<0,05 yang berarti variabel pelayanan secara parsial berpengaruh positif terhadap keputusan nasabah dalam memilih bank syariah. Tingkat signifikasi variabel promosi 0,000<0,05 yang berarti variabel promosi secara parsial berpengaruh posotif terhadap keputusan nasabah dalam memilih bank syariah. Tingkat signifikasi variabel pengetahuan tentang produk 0,012<0,05 yang berarti variabel pengetahuan tentang produk secara parsial berpengaruh positif terhadap keputusan nasabah memilih bank syariah.Ada tiga variabel yang nilai signifikannya dibawah 0.05, yaitu variabel dengan nilai pelayanan, promosi dan pengetahuan tentang produk. Hal ini menunjukkan bahwa ketiga variabel tersebut berpengaruh signifikan terhadap keputusan nasabah dalam memilih bank syariah.
Pelaksanaan Proses Peminatan Berdasarkan Implementasi Kurikulum 2013 Terhadap Tingkat Kepuasan Peserta Didik
Authors: Melmambessy Rulof
Published: February 2018

Curriculum 2013 is a curriculum that prioritizes understanding, skills, and character education, students are required to understand the material, active in discussions and presentations and have a high discipline manners. In the 2013 curriculum, the division of departments through junior high school grades is done when students are still in class X. This study aims to determine the level of student satisfaction with the implementation of the division of majors conducted by the teachers at the time the students are still on Class X and based on SMP report cards. The department is one way to achieve the ideals and future of the students because the majors aim to develop the talents and abilities of the students. Instrument that researchers use is with the division of questionnaires, data collection techniques that the authors use are interviews, study libraries and documentation. Based on the research, it is found that the level of student satisfaction toward the implementation of departmental division based on the 2013 curriculum is very high or it can be said that the students who do not receive the results of the department division through the 2013 curriculum are very low. Therefore, the 2013 curriculum is very well used in the students next year or academic year 2017/2018.
Profesi Konselor dalam Kurikulum 2013 dan Permasalahannya
Authors: Wibowo Mungin Eddy
Published: February 2018

Implementation of the 2013 curriculum will create problems for high school learners who can not afford in choosing the right direction of subject groups and subjects appropriately, so that will cause difficulties in learning and tendency to fail in learning. The determination of the direction of the subject group and the subjects should be in accordance with the general basic skills (intelligence), talents, interests and preferences of each learner so that the learning process goes well and the tendency to succeed in learning. Therefore, the guidance and counseling service in the direction of the subject group and the subject is very necessary for the learner to be able to make choices according to his potential ability and the possibility of success in learning.
Penggunaan Metode Inquiri untuk Meningkatkan Hasil Belajar Mata Pelajaran IPS pada Siswa Kelas IV SD
Authors: Abdullah Aleyda
Published: February 2018

The research that will be carried out is aimed to know the use of inquiri method can improve student learning outcomes in IPS subjects in class IV SD Negeri 5 Ambon. This research is a qualitative research with type of classroom action research. The subjects of this study are the students of grade IV (four) SD Negeri 5 Ambon Nusaniwe Subdistrict, which amounted to 35 students. Data were collected with observation sheets. In the study of this class action is used qualitative description analysis, this analysis is calculated by using simple statistic. In the initial test students who score ≥ 65 as many as 57.14% of students, after the first cycle increased to 73.50% students. The average initial test score of 30.85% and after the first cycle increased to 71.14%. On the second cycle also increased the students who get the value of ≥ 65 as many as 81.76% of students. The average value of the end test of cycle II increased to 81.14%.
Penerapan Pembelajaran Kooperatif Tipe Picture and Picture untuk Meningkatkan Perkembangan Kognitif Anak Usia Dini di Kelompok Bermain
Authors: Tutupary Rosmaryn
Published: February 2018

The world of children is a world of play, and learning is done with or while playing that involves all the senses of the child. Paud teachers and parents need to look at the aspects of personality that exist in the development of children, including aspects of cognitive aspects, aspects of moral values, aspects of intelligence, motor aspects, social aspects of emotional. These five aspects may affect the thinking aspect of the child, and this is highly dependent on the ability of each individual. Therefore, children need to get good and proper stimulation to optimize aspects of its development. This study aims to determine the application of cooperative learning picture and picture type in improving early childhood cognitive development in KB Mawar FKIP Unpatti Ambon. This research is a Classroom Action Research. The subjects of this study were students aged 4-5 years KB Roses FKIP Unpatti Ambon which amounted to 10 people. Data collection techniques are observation and interview. This classroom action research procedure is carried out in two cycles, namely cycle I and cycle II. To know the result of student learning by using learning strategy with song on cognitive aspect conducted evaluation in the form of observation to cognitive aspect. Where indicators are performed by holding observations after completion of learning in each cycle at the end of the second meeting. The results showed that in the first cycle, there are still students who do not meet the criteria of the indicators conducted by the tutor, so it can be said as a weakness encountered in the implementation of the first cycle action, while in cycle II students are very active hear the teacher explanation. Very active in question is that students can follow the teacher's explanation well so that what is assigned can be done well. Thus it can be concluded that by using cooperative learning picture and picture type can develop early childhood cognitive in KB Mawar FKIP Unpatti Ambon.
Konseling Lintas Budaya Berbasis Sumber Daya Lokal dan Kebencanaan
Authors: Hadiwinarto Hadiwinarto
Published: February 2018

Target of this research is identify human being resources of local, psychological social needs of society, social institutes of potential local social for cross cultural konseling. Research responder 60 one who are is chosen. Data collecting by using technique of Focus Group Discussion and of cuesioner. Technique analyse data use descriptive qualitative and quantitative modestly. Result of elite indicate that disaster victim require psychological social service, ready to become volunteer cross cultural konseling and require special institute
Penerapan Pembelajaran Collaborative Problem Solving untuk Meningkatkan Self-Concept Mahasiswa
Authors: Takaria Johannis
Published: February 2018

The focus of this research is to comprehensively analyze the differences in self concept improvement of Primary School teacher candidates in terms of early mathematical ability (KAM). This difference analysis is facilitated using collaborative problem solving (CPS) model, with Quasi Experimental research method and designed with Nonequivalent Pretest-Posttest Control Group type. The study sample involved 60 PGSD students in academic year 2016/2017. Identified through the results of the study that there is a difference in the increase of self-concept of student statistics, where the group of students who get the lectures with the CPS model get a higher increase than the group of students using expository learning (EPS), both whole students and based on the level of early mathematical ability (KAM) . This improvement difference is due to the effective use of CPS model. Collaborate in static lectures can improve student's positive self concept because in the transformation process there is an exchange of creative ideas among students.
Childbirth Is Not an Emergency: Informed Consent in Labor and Delivery
Authors: Wolf Allison B. , Charles Sonya
Published: February 2018

Most agree that informed consent must be obtained for medical procedures. Yet, empirical studies and anecdotal accounts show that women's right to informed consent and to refusal of treatment are routinely undermined or ignored during childbirth. The primary reasons currently accepted for exempting a procedure from the informed consent requirement are life-threatening or emergency circumstances and protecting the life of a minor or incompetent person. We will show that these do not apply in low-risk childbirth, and, thus, that obtaining informed consent throughout the normal course of labor and delivery is morally required.
Hysterical Girls: Combat Trauma as a Feminist Issue
Authors: McDonald MaryCatherine
Published: February 2018

The cluster of symptoms now called post-traumatic stress disorder (PTSD) had its beginning in “hysteria,” a syndrome that affected only women. This paper explores the way that the perniciously essentialist beginnings of trauma research have bled into our understanding and treatment of trauma today. I use the work of Sandra Lee Bartky, who argues that psychological fragmentation forms the basis of the oppression of women, to show the way that the psychological landscape has been shaped in parallel ways for the traumatized veteran. Understanding trauma in nongendered ways illustrates that the trauma response is an adaptive mechanism born of resilience.
Toward a Historicism of Setting:Hamiltonand American History
Authors: Styrt Philip Goldfarb
Published: February 2018

This essay analyses the historical setting of Lin-Manuel Miranda’s Hamilton: An American Musical, using the play as a test case for a more general approach to historical drama. It suggests that Hamilton structures itself around a familiar, publicly available set of narratives of early American history, playing off the audience’s likely awareness of these narratives to deepen its emotional impact. Hamilton’s engagement with this familiar history activates the dissonance of the musical’s cross-racial casting and hip-hop aesthetic in order to produce what Miranda has called “a story about America then, told by America now,” simultaneously celebrating and critiquing the past. Based on this analysis of Hamilton, I argue for engaging with other historical plays through their settings, with careful attention to what a contemporary audience might have known or understood about the periods depicted.
LRRK2 p.Ile1371Val Mutation in a Case with Neuropathologically Confirmed Multi-System Atrophy
Authors: Lee Kelsey , Nguyen Khanh-Dung , Sun Chao , Liu Mei , Zafar Faria , Saetern Jimmy , Flierl Adrian , Tetrud James W. , Langston J. William , Dickson Dennis , Schüle Birgitt
Published: February 2018

Background:

Mutations in the leucine rich repeat kinase 2 ( LRRK2) gene are among the most common genetic causes of Lewy body Parkinson’s disease (PD). However, LRRK2 mutations can also lead to a variety of pathological phenotypes other than typical PD, including relatively pure nigrostriatal cell loss without alpha-synuclein-positive Lewy bodies or Lewy neurites, progressive supranuclear palsy (PSP), and multiple system atrophy (MSA). The mechanisms behind this remarkable pleomorphic pathology are currently unclear.

Objective:

To genetically and pathologically characterize a case with a LRRK2, p.Ile1371Val rare variant and pathologically proven MSA.

Methods:

From the brain donation program at the Parkinson’s Institute and Clinical Center, we selected 26 brains with family history and a with clinicopathological diagnosis of PD ( n = 20), MSA ( n = 4), or PSP ( n = 2). We performed neuropathological evaluation, including alpha-synuclein and tau immunohistochemistry and sequenced 188 genes that have been reported as causative for or associated with neurodegenerative diseases.

Results:

We identified a known LRRK2, p.Ile1371Val genetic variant in a case with clinically diagnosed and pathologically proven MSA. Neuropathology revealed that the olivopontocerebellar system was more affected than the striatonigral system.

Conclusions:

Our data suggest that genetic variants in the LRRK2 gene can present clinically and neuropathologically as MSA. One other LRRK2 genetic variant ( LRRK2, p.Ile2020Thr) has been reported with a neuropathological diagnosis of MSA. Interestingly, the LRRK2 variant ( LRRK2, p.Ile1371Val) identified here has been reported previously in a postmortem case with Lewy body PD. Future studies are critical to discover the mechanisms leading to different neurodegenerative trajectories both in neuronal and glial cell populations.
Urinary Dysfunctions and Post-Void Residual Urine in Typical and Atypical Parkinson Diseases
Authors: Lee Yang-Hyun , Lee Jee-Eun , Ryu Dong-Woo , Oh Yoon-Sang , Lee Kwang-Soo , Hong Sung-Hoo , Kim Joong-Seok
Published: February 2018

Background:

Urinary dysfunction is relatively common, however, is often underestimated and diagnosed by subjective questionnaires in patients with Parkinsonism.

Objective:

To determine the correlation between subjective urinary dysfunction and post-void residual urine volume in patients with Parkinson’s disease (PD), multiple system atrophy (MSA) and progressive supranuclear palsy (PSP), and to assess the relationship between clinical characteristics and subjective or objective urinary dysfunction.

Methods:

A total of 196 patients with de novo Parkinsonism without urological and gynecological disorders were included. For all subjects, data were collected on sonographic post-void residual urine volume and urinary symptoms. All patients were also assessed on motor symptom severity, cognitive and affective measurements, other nonmotor symptoms, 39-item Parkinson’s Disease Questionnaire, and renal functions.

Results:

Seventeen out of 196 parkinsonian patients showed abnormal post-void residual urine volumes, with ≥100 ml. The MSA group showed significantly higher post-void residual urine volume compared to the PD and PSP groups. Symptoms of the sense of incomplete emptying, weak urine stream, and nocturia were strongly correlated with post-void residual urine volume. Post-void residual urine volume was positively related to autonomic symptoms, other non-motor symptoms, patient activities of daily living, and negatively related to renal function.

Conclusion:

Increased post-void residual urine volumes were observed in small portion of early drug-naïve Parkinsonian patients, especially in MSA. Post-void residual urine volume was significantly related to subjective urinary and other autonomic dysfunctions. Voiding dysfunction is associated with not only end organ damage, but also other nonmotor dysfunctions and patient activities of daily living.
Cardiovascular Risk Factor Burden in Veterans and Non-Veterans with Parkinson Disease
Authors: Kotagal Vikas , Albin Roger L. , Müller Martijn L.T.M , Bohnen Nicolaas I.
Published: February 2018

Background:

Medical comorbidities, including cardiovascular risk factors such as hypertension and diabetes, influence disease progression in Parkinson disease (PD) and may be variably present in different clinical populations.

Objective/Methods:

We conducted a retrospective nested case-control study of 29 Veterans with PD and 29 non-Veteran PD controls. The groups were matched for age, gender, and disease duration. Both groups underwent clinical and imaging testing as part of their participation in a larger cross-sectional PD observational study at our research center. Veterans were recruited primarily from movement disorders neurology clinics at the Ann Arbor Veterans Affairs (VA) Health System. Non-Veterans were recruited primarily from analogous clinics at the University of Michigan Health System. We explored differences in cardiovascular risks factor burden between the groups.

Results:

Veterans with PD showed higher scores on the simplified Framingham 10-year general cardiovascular disease risk calculator (FR score; 27.3% (11.5) vs. 20.7% (6.8); t = –2.66, p = 0.011) and fewer years of self-reported education (14.5 (2.5) vs. 16.7 (2.6); t = 3.33, p = 0.002). After adjusting for age, disease duration, education, and the use of antihypertensive medications, Veterans showed higher FR scores ( t = 2.95, p = 0.005) and a higher intra-subject ratio of FR score to age-and-gender normalized FR score ( t = 2.49, p = 0.016), representing an elevated component of modifiable cardiovascular risk factor burden.

Conclusion:

Cardiovascular comorbidities are common in Veterans with PD and may be more severe than in non-Veteran PD populations. These findings merit replication in other representative cohorts. Veterans may be a preferred population for clinical trials evaluating cardiovascular risk factor management on PD progression.
Alpha-Synuclein Glycation and the Action of Anti-Diabetic Agents in Parkinson’s Disease
Authors: König Annekatrin , Vicente Miranda Hugo , Outeiro Tiago Fleming
Published: February 2018

Parkinson’s disease (PD) is a neurodegenerative disorder with complex etiology and variable pathology. While a subset of cases is associated with single-gene mutations, the majority originates from a combination of factors we do not fully understand. Thus, understanding the underlying causes of PD is indispensable for the development of novel therapeutics. Glycation, the non-enzymatic reaction between reactive dicarbonyls and amino groups, gives rise to a variety of different reaction products known as advanced glycation end products (AGEs). AGEs accumulate over a proteins life-time, and increased levels of glycation reaction products play a role in diabetic complications. It is now also becoming evident that PD patients also display perturbed sugar metabolism and protein glycation, including that of alpha-synuclein, a key player in PD. Here, we hypothesize that anti-diabetic drugs targeting the levels of glycation precursors, or promoting the clearance of glycated proteins may also prove beneficial for PD patients.
Medicated Straws Based on Electrospun Solid Dispersions
Authors: Farkas Balázs , Balogh Attila , Farkas Attila , Domokos András , Borbás Enikő , Marosi György , Nagy Zsombor Kristóf
Published: February 2018

Novel medicated straws were developed based on drug-loaded electrospun fibers prepared by direct current electrospinning (DCES) and high-speed electrospinning (HSES) of scaled-up productivity. Good quality micro- and nanofibers were electrospun using both techniques despite the multiple times higher throughput rate of HSES based on the scanning electron microscopic imaging (SEM). Solid state analyses revealed that the poorly soluble model drug carvedilol (CAR) was dispersed in an amorphous form in the electrospun polyvinylpyrrolidone (PVPK30) fibers. In vitro dissolution studies revealed ultrafast drug release from the prepared fibrous formulations inserted into plastic straws. Based on the results the developed drug delivery system is suitable for storing the formulation in a solid dosage form and in situ turning it into liquid form when administered.
Homogeneous and Inhomogeneous Maxwell’s Equations in Terms of Hodge Star Operator
Authors: Hossine Zakir , Ali Md Showkat
Published: February 2018

The main purpose of this work is to provide application of differential forms in physics. For this purpose, we describe differential forms, exterior algebra in details and then we express Maxwell’s equations by using differential forms. In the theory of pseudo-Riemannian manifolds there will be an important operator, called Hodge Star Operator. Hodge Star Operator arises in the coordinate free formulation of Maxwell’s equation in flat space-time. This operator is an important ingredient in the formulation of Stoke’stheorem.GANIT J. Bangladesh Math. Soc.Vol. 37 (2017) 15-27
Stability Analysis of a Nonlinear System with Different Growth Functions
Authors: Kamrujjaman Md , Niger Ashrafi Meher
Published: February 2018

A competitive mathematical model for the growth of two species is considered in this study. The main goal of the present study is to investigate the roles of two different growth functions: the logistic growth and the food limited growth. We established the main results that determine the asymptotic stability of semi-trivial as well as the coexistence solutions. If higher carrying capacity is embodied for the population following logistic growth then competitive exclusion of a food limited population is imminent and vice versa.GANIT J. Bangladesh Math. Soc.Vol. 37 (2017) 111-119
The Infinitude of Prime Numbers Revisited
Authors: Chowdhury Munibur Rahman
Published: February 2018

We present here a proof of the infinitude of prime numbers based on the sequencen! + k, k = 2, 3, …, n.GANIT J. Bangladesh Math. Soc.Vol. 37 (2017) 185-187
Ambivalent Relationships: London's Youth Culture and the Making of the Multi-Racial Society in the 1960s
Authors: Fuhg Felix
Published: February 2018

The emergence and formation of British working-class youth cultures in the 1960s were characterized by an ambivalent relationship between British identity, global culture and the formation of a multicultural society in the post-war decades. While national and local newspapers mostly reported on racial tensions and racially-motivated violence, culminating in the Notting Hill riots of 1958, the relationship between London's white working-class youth and teenagers with migration backgrounds was also shaped by a reciprocal, direct and indirect, personal and cultural exchange based on social interaction and local conditions. Starting from the Notting Hill Riots 1958, the article reconstructs places and cultural spheres of interaction between white working-class youth and teenagers from Caribbean communities in London in the 1960s. Following debates and discussions on race relations and the participation of black youth in the social life of London in the 1960s, the article shows that British working-class youth culture was affected in various ways by the processes of migration. By dealing with the multicultural dimension of the post-war metropolis, white working-class teenagers negotiated socio-economic as well as political changes, contributing in the process to an emergent, new image of post-imperial Britain.
Bloody Revolutions, Fascist Dreams, Anarchy and Peace: Crass, Rondos and the Politics of Punk, 1977–84
Authors: Lohman Kirsty , Worley Matthew
Published: February 2018

On 8 September 1979, the English punk bands Crass and Poison Girls played a benefit gig with the Dutch punk band Rondos at London's Conway Hall. The gig has become notorious in British punk history due to the violence that broke out between right-wing and left-wing factions, bringing to the fore wider political tensions evident across punk's fragmented milieu. Not only did it embody the attempts of the far-right and far-left to co-opt punk's rebellion, but it also brokered a debate as to the nature of punk's politics and its relationship to existing political movements. In many ways, punk's politics – especially the overt politics of bands such as Crass and Rondos – was defined against the systematic ideologies of the left and right. Nevertheless, the controversy that followed the Conway Hall gig ended the transnational friendship that had been established between the bands, leading to a protracted debate on questions of political violence, pacifism and anarchism. This article provides a comparative study of punk politics. In particular, it explores the different social and political contexts that informed punk in Britain and the Netherlands, revealing how punk cultures transmitted, mutated and evolved across national boundaries.
Boules de sensations-pensées-formes in Christophe Tarkos's Poetry
Authors: Barda Jeff
Published: February 2018

This article explores Christophe Tarkos's poetic work and analyses which conception of thought and sensation is developed in his work. His poetry, I argue, rests on a materialist conception of poetic writing construed as a kneading process in which language can be shaped and reshaped continually. This manipulation gives rise to a complex, paradoxical discourse, characterized by a lack of causality which reflects an idiotic perception of the world and objects. This immanent conception of language reduced to its simplest expression stands in stark contrast with past poetic models and conveys a new definition of anti-lyrical poetic writing and of the poetic subject.
Penser l’échange artistique franco-algérien: la bande dessinée Alger–Marseille: allers-retours de Nawel Louerrad et Benoît Guillaume, et le musée du MuCEM
Authors: Gueydan-Turek Alexandra
Published: February 2018

(French): Dans la bande dessinée Alger–Marseille:allers-retours, l'artiste algérienne Nawel Louerrad et son homologue français Benoît Guillaume racontent leurs voyages respectifs à Marseille et à Alger. Le fruit d'une commande du Musée des civilisations de l'Europe et de la Méditerranée (MuCEM), ce projet artistique se situe dans le prolongement d'une muséographie renouvelée dont le parti pris serait le décentrement du regard et le relationnel. Dans ce contexte, cet article s'interroge sur la nature des échanges suscités par le projet muséal postcolonial à travers cette bande dessinée.

Nous verrons que si les deux récits offrent des visions géo-poétiques et artistiques a priori irréconciliables, l'album dans sa totalité promeut une éthique de l'horizontalité; il se transforme en espace de cohabitation, voire de partage. La résidence croisée des bédéistes et son produit artistique contribuent au final au projet muséal postcolonial du MuCEM en mettant en œuvre une nouvelle dynamique artistico-culturelle entre l'Algérie et la France.
Effect of Digestate and Biochar Amendments on Photosynthesis Rate, Growth Parameters, Water Use Efficiency and Yield of Chinese Melon (Cucumis melo L.) under Saline Irrigation
Authors: Elbashier Mohammed M. A. , Xiaohou Shao , Ali Albashir A. S. , Mohmmed Alnail
Published: February 2018

Despite the recent interest in biochar and digestate as soil amendments for improving soil quality and increasing crop production, there is inadequate knowledge of the effect of the combination of biochar and digestate, particularly under saline irrigation conditions. A pot experiment with Chinese melon was conducted in a greenhouse, biochar (5%) and digestate (500 mL/pot) were used with and without the recommended mineral NPK (Nitrogen, Phosphorus and Potassium) fertilizer dose (120-150-150 Kg ha−1). The plants were irrigated with tap water (SL0) and 2 dS/m (SL1) NaCl solution. The growth, photosynthesis rate, water use efficiency (WUE) and yield of Chinese melon were affected positively when biochar was combined with digestate amendment, particularly under saline irrigation water with and without mineral NPK fertilizer. The maximum yield under normal water was obtained by digestate (SL0: 218.87 t ha−1) and biochar amendment combined with digestate (SL1: 118.8 t ha−1) under saline water. The maximum WUE values were noticed with the biochar and digestate combination under all water treatments (SL0: 32.2 t ha−1 mm−1 and SL1: 19.6 t ha−1 mm−1). It was concluded that digestate alone was more effective than the use of biochar, particularly with normal water. The combination of biochar with digestate had a significant effect on the Chinese melon growth, photosynthesis rate, water use efficiency and yield under saline irrigation, and it can be used as an alternative fertilizer for mineral NPK fertilizer.
In the Eye of the Beholder: Owner Preferences for Variations in Cats’ Appearances with Specific Focus on Skull Morphology
Authors: Farnworth Mark J. , Packer Rowena M. A. , Sordo Lorena , Chen Ruoning , Caney Sarah M. A. , Gunn-Moore Danièlle A.
Published: February 2018

Changes in the popularity of cat breeds are largely driven by human perceptions of, and selection for, phenotypic traits including skull morphology. The popularity of breeds with altered skull shapes appears to be increasing, and owner preferences are an important part of this dynamic. This study sought to establish how and why a range of phenotypic attributes, including skull shape, affect preferences shown by cat owners. Two questionnaires were distributed on-line to cat owners who were asked to rate preferences for pictures of cats on a 0–10 scale. Veterinarian consensus established the skull types of the cats pictured (i.e., level of brachycephaly (BC) or dolichocephaly (DC)). Preferences were then explored relative to cat skull type, coat and eye color, and coat length. Generalized estimating equations identified relationships between physical characteristics and respondent ratings. Further sub-analyses explored effects of respondents’ occupation, location and previous cat ownership on rating scores. Overall, cats with extreme changes in skull morphology (both BC and DC) were significantly less preferred than mesocephalic cats. Green eyes, ginger coat color and medium length coat were most preferred. Current owners of a BC or DC pure bred cat showed significantly greater preference for cats with similar features and significantly lower preference for the opposite extreme. Respondents from Asia were significantly more likely to prefer both BC and DC cats as compared to respondents from other locations. Finally, those in an animal care profession, as compared to other professions, provided a significantly lower preference rating for BC cats but not for DC cats. This work, despite the acknowledged limitations, provides preliminary evidence that preferences for cat breeds, and their associated skull morphologies, are driven by both cultural and experiential parameters. This information may allow for better targeting of educational materials concerning cat breeds.
A Polar Sulfamide Spacer Significantly Enhances the Manufacturability, Stability, and Therapeutic Index of Antibody–Drug Conjugates
Authors: Verkade Jorge , Wijdeven Marloes , Van Geel Remon , Janssen Brian , Van Berkel Sander , Van Delft Floris
Published: February 2018

Despite tremendous efforts in the field of targeted cancer therapy with antibody–drug conjugates (ADCs), attrition rates have been high. Historically, the priority in ADC development has been the selection of target, antibody, and toxin, with little focus on the nature of the linker. We show here that a short and polar sulfamide spacer (HydraSpace™, Oss, The Netherlands) positively impacts ADC properties in various ways: (a) efficiency of conjugation; (b) stability; and (c) therapeutic index. Different ADC formats are explored in terms of drug-to-antibody ratios (DAR2, DAR4) and we describe the generation of a DAR4 ADC by site-specific attachment of a bivalent linker–payload construct to a single conjugation site in the antibody. A head-to-head comparison of HydraSpace™-containing DAR4 ADCs to marketed drugs, derived from the same antibody and toxic payload components, indicated a significant improvement in both the efficacy and safety of several vivo models, corroborated by in-depth pharmacokinetic analysis. Taken together, HydraSpace™ technology based on a polar sulfamide spacer provides significant improvement in manufacturability, stability, and ADC design, and is a powerful platform to enable next-generation ADCs with enhanced therapeutic index.
Morphological Pathways of Mitochondrial Division
Authors: Tandler Bernard , Hoppel Charles L. , Mears Jason A.
Published: February 2018

Mitochondrial fission is essential for distributing cellular energy throughout cells and for isolating damaged regions of the organelle that are targeted for degradation. Excessive fission is associated with the progression of cell death as well. Therefore, this multistep process is tightly regulated and several physiologic cues directly impact mitochondrial division. The double membrane structure of mitochondria complicates this process, and protein factors that drive membrane scission need to coordinate the separation of both the outer and inner mitochondrial membranes. In this review, we discuss studies that characterize distinct morphological changes associated with mitochondrial division. Specifically, coordinated partitioning and pinching of mitochondria have been identified as alternative mechanisms associated with fission. Additionally, we highlight the major protein constituents that drive mitochondrial fission and the role of connections with the endoplasmic reticulum in establishing sites of membrane division. Collectively, we review decades of research that worked to define the molecular framework of mitochondrial fission. Ongoing studies will continue to sort through the complex network of interactions that drive this critical event.
Structure and Sound Absorption Properties of Spiral Vane Electrospun PVA/PEO Nanofiber Membranes
Authors: Liu Huan , Zuo Baoqi
Published: February 2018

Noise pollution has become one of the four major pollution issues in the world and has drawn much attention recently. Controlling the sound source and using sound-absorbing materials reasonably is considered an effective way to reduce noise. Due to the high porosity and specific surface area, nanofibers membrane is widely used in the field of the sound absorption. Polyvinyl alcohol (PVA) and Polyethylene oxide (PEO) are both water-soluble polymers with good film-forming properties that can be mixed in any proportion. In this paper, nanofiber membranes were prepared by spiral vane electrospinning with different contents of PVA and PEO. The nanofibers membranes were characterized by Fourier Transform-Infrared (FT-IR), X-ray diffraction (XRD), 3D-M, and scanning electron microscopy (SEM). The sound absorption property of nanofibers membranes and the compositions (nanofiber membranes and needle punched non-woven fabric) were tested with an impedance tube. The results demonstrate that the addition of PEO changed the morphological characteristics and construct of PVA, sound absorption properties had undergone great changes.
Emergence of White Organic Light-Emitting Diodes Based on Thermally Activated Delayed Fluorescence
Authors: Xiao Peng , Dong Ting , Xie Jianing , Luo Dongxiang , Yuan Jian , Liu Baiquan
Published: February 2018

Recently, thermally activated delayed fluorescence (TADF) organic light-emitting diodes (OLEDs) have attracted both academic and industrial interest due to their extraordinary characteristics, such as high efficiency, low driving voltage, bright luminance, lower power consumption and potentially long lifetime. In this invited review, the fundamental concepts of TADF have been firstly introduced. Then, main approaches to realize WOLEDs based on TADF have been summarized. More specifically, the recent development of WOLEDs based on all TADF emitters, WOLEDs based on TADF and conventional fluorescence emitters, hybrid WOLEDs based on blue TADF and phosphorescence emitters and WOLEDs based on TADF exciplex host and phosphorescence dopants is highlighted. In particular, design strategies, device structures, working mechanisms and electroluminescent processes of the representative WOLEDs based on TADF are reviewed. Finally, challenges and opportunities for further enhancement of the performance of WOLEDs based on TADF are presented.