bluuebunny/crossref_metadata_2025 huggingface dataset:
Successful fractionated undiluted doses of COVID-19 vaccine in five cases of suspected allergic reactions to the first dose
Authors: Rivolta Federica , Cappelletti Camilla , Sangalli Andrea , Gallo Alessandra Chiei , Pravettoni Valerio
Published: April 2022

After a suspected allergic reactions to first dose of mRNA COVID-19
vaccine, given the PEG skin tests negativity and tolerance in vivo to
PEG containing drugs, five patients were vaccinated with the second dose
of Pfizer-Biontech undergoing a fractional protocol, with antihistamine
premedication, without presenting immediate or delayed reactions.
All-optical frequency encoded dibit-based parity generator using reflective semiconductor optical amplifier with simulative verification
Authors: Bosu Surajit , Bhattacharjee Baibaswata
Published: April 2022

High-speed signal computation and communication are an essential part of modern communication that increases optical necessity. Therefore, researchers developed different types of digital devices in the all-optical domain. Due to the versatile gain medium of reflective semiconductor optical amplifiers (RSOAs), it has various important applications in passive optical networks. In comparison with semiconductor optical amplifier (SOA), RSOAs exhibit better gain performance because of their double pass property. Therefore, RSOA shows better switching properties. In this communication, co-propagation scheme of RSOA is used to design and analyze a frequency encoded dibit-based parity generator. Taking the advantages of RSOA like high switching speed, low noise, high gain, and low power consumption, the proposed design achieves these qualities. This design simulated in MATLAB and simulated outputs accurately verify the truth table.
Functions of the Forensic Doctor as Heirs of Civil Registry Doctors
Authors: Pastor María Elena Brea
Published: April 2022

The work shows the changes that have arisen in the functions attributed to the Doctors of the Civil Registry since the disappearance of this institution in 1992 until today. The problems currently generated are presented to the Forensic Doctor who has assumed these functions.
Penyebab Sulitnya Siswa Menjawab Soal HOTS dalam Pembelajaran Sosiologi di Kelas XI IPS SMAN 1 Batang Kapas Pesisir Selatan
Authors: Dalman Rizki Pratama , Junaidi Junaidi
Published: April 2022

This article was written to find out the cause of the difficulty of students answering the HOTS questions in learning sociology in class XI IPS at SMAN 1 Batang Kapas, Pesisir Selatan. This type of research uses qualitative methods with the type of case study research. The criteria for informants in this study were students of class XI IPS and sociology teachers in class XI IPS at SMAN 1 Batang Kapas. The informant selection technique in this study used purposive sampling. This study discusses that, the cause of the difficulty of students answering HOTS questions is caused by (1) Students Do not Understand the Material. Interviews with several students obtained information that they did not understand the material because of the difficulty of the teacher's teaching method, either because the teacher was difficult to understand, the delivery of the material was not good or the teacher was too quick to teach the material in the learning process. Another thing based on observations can be found the cause of difficulty understanding the material because they are not serious in learning. This can be seen from the attitude of those who watch while studying and some are related to other students. Students' disinterest in learning is caused by teachers who teach a lot using the lecture method so that students become bored and students' thinking skills are not honed. The cause of teachers who use the lecture method a lot is due to the lack of training that can be related to HOTS learning and about HOTS, so that the experience of teachers about HOTS is still relatively low and (2) Students Do not Understand Question Commands. Based on interviews, information was obtained that the reason why students did not understand the instructions about their reasons was never discussed by the teacher about what HOTS questions were and what were the requirements for a HOTS question. This is permitted by the teacher where the teacher only gives HOTS questions to students, the HOTS questions given are also still few so that students are not used to it and do not only answer the HOTS questions that are tested on them. This happened because teachers did not receive training on HOTS, besides that the comprehension ability of class XI IPS students could be said to be still in the lower middle class, which was also confirmed by the Sociology teacher.
Penggunaan Media Internet Sebagai Sumber Belajar di Kalangan Peserta Didik Kelas XII IPS di SMA Pertiwi 1 Padang Pada Masa Pandemi Covid-19
Authors: Reza Siti Annisa , Nora Desri
Published: April 2022

This research was motivated by the use of internet media as a learning resource among students of class XII IPS at SMA Pertiwi 1 Padang during the Covid-19 pandemic. This study aims to explain the use of internet media as a learning resource among students of class XII IPS at SMA Pertiwi 1 Padang. This study uses an approach approach, with the type of phenomenological research, the selection of informants is done by purposive sampling with 18 informants, data collection by observation, in-depth interviews, and documentation studies. Data Reduction (Data Reduction), Data Display (Data Presentation), and Conclusion Drawing/Verification (Conclusion Drawing). The research location is in SMA Pertiwi1 Padang. The results of this study show that there are six motives that cause students to use the internet as a learning resource in the midst of the Covid-19 pandemic. 1) Efforts to fulfill school assignments. 2) Fast pace in information retrieval. 3) Information on learning resources on the internet is more complete. 4) Up-to-date notifications. 5) Make the task easier. 6) Cheaper rates.
AVALIAÇÕES EXTERNAS E EM LARGA ESCALA NO CONTEXTO DA POLÍTICA EDUCACIONAL DO ESTADO DE GOIÁS
Authors: Iris de Queiroz Welcianne , Nunes Militão Sílvio César
Published: April 2022

O presente artigo apresenta os resultados de uma pesquisa que analisa os impactos do gerencialismo na política educacional do Estado de Goiás. No âmbito micro (estado), escrutina aspectos determinantes da (des)qualificação do ensino público e sua relação com as políticas educacionais norteadas por orientações de organismos multilaterais (macro). Investiga qual o conceito de qualidade perpassa o discurso oficial e como tal conceito está vinculado aos resultados de desempenho produzidos pelas avaliações externas e em larga escala. A pesquisa de abordagem qualitativa do tipo bibliográfica e documental, aporta-se no referenciais de (AFONSO, 2009, 2012; LIBÂNEO, 2018; FREITAS, 2012, 2018; BALL, 2002), elegendo ainda como corpus de análise os documentos do Banco Mundial, da Organização das Nações Unidas para a Educação, a Ciência e a Cultura, Organização de Cooperação e de Desenvolvimento Econômico, da Secretaria de Estado de Educação de Goiás e sites oficiais da atual gestão deste estado. Após a revisão de literatura, conclui-se que os resultados das avaliações externas e em larga escala têm sido usados como meio de controle e regulação das escolas e professores, por meio de prêmios e sanções e têm tido um efeito contrário ao que o discurso oficial têm propalado, promovendo uma desqualificação da educação. É possível, no entanto, uma ação contra hegemônica, já que “as escolas também fazem políticas” e que os professores são tanto “sujeitos como atores dessas políticas”, logo eles não apenas implementam, mas, também, as reconfiguram e as transformam no contexto da sala de aula.
Peran Apoteker dalam Pengelolaan Penyakit Degeneratif di Dusun Mergan Sendangmulyo, Sleman, D.I. Yogyakarya
Authors: Virginia Dita Maria , Widayati Aris
Published: April 2022

Findings of the preliminary survey showed a high proportion of geriatric people in Dusun Mergan, Sendangmulyo, Sleman, which leads to high risk of cardiovascular and other degenerative diseases. This community service program aimed to identify the health status of Mergans people through health screening and to help them to maintain their health. This program was conducted in collaboration between the Faculty members and students of Pharmacy Faculty of Universitas Sanata Dharma Yogyakarta (USD). There were two consecutive periods; the first was in 7th of May and the second was in 22nd of October 2018. Health education, health screening, and health examination were conducted in each period. There were 93 people involved in the first period and 64 people in the second; however, only 32 persons who completely attended the two meeting periods. The program resulted data of 60.7% Mergans people with a risk of dyslipidemia, and 59.0% with hyperglycemic. There was no significant difference between the first and the second periods of examination of glucose level, cholesterol, and uric acid. Therefore, it is urgent to educate people in Mergan Village to promote and maintain a healthy lifestyle in order to decrease morbidity of degenerative disease in the community.
MENGEMBANGKAN INDUSTRI BRIKET DENGAN MEMPERGUNAKAN MESIN PENGERING BRIKET ENERGI LISTRIK
Authors: Purwadi PK , Mungkasi Sudi , Lukiyanto YB
Published: April 2022

In producing briquettes, the industry has problems in drying its briquettes. During this time briquette drying always involves solar energy. Drying with solar energy has weaknesses, namely (a) the ability to dry briquettes for a long time, cannot be accelerated (b) in the rainy season, solar energy is difficult to rely on, so the production capacity of briquettes per day decreases (c) to produce briquettes with large capacity, requiring a lot of raw material availability. These three weaknesses can be overcome if the briquette drying is done by using an electric energy briquette dryer. By using electric energy drying, the development of the briquette industry can be easily carried out. The purpose of this service implementation is to assist the human resources (HR) of the two briquette industry partners to increase, have complete knowledge of the electric energy briquette drying machine and use briquette drying machines to develop the industry. The results of the implementation of this service are (a) both partners know the briquette drying machine well and have the ability to make and function the electric energy briquette dryer (b) the two partners have a clear understanding to increase the briquette production capacity and determine all requirements and steps must be done to achieve production capacity as desired.
MENINGKATKAN, BERSAMA PARA GURU, KEMAMPUAN BERLITERASI SISWA SDN SARIKARYA, YOGYAKARTA
Authors: Sukamto Katharina Endriati , Purwo Bambang Kaswanti
Published: April 2022

The present paper is a report of two activities of community service on developing students literacy at Sarikarya Elementary School in Yogyakarta on 20 October 2017 and 11 May 2018. The activities sprout from the result of the research conducted in the same school in August 2017 to find out to what extent the children from class 1 to class 6 make progress in their writing of a descriptive text. By using the result of our research as the basic material for our community service, we had a discussion with the teachers so that they would be more aware of the literacy competence of their students, and by so doing they could help their students develop their students literacy in writing. This community service also aims to discuss with teachers what kind of activities could be carried out in class to support the development.
PENGEMBANGAN BISNIS SOSIAL DARI PENGELOLAAN LIMBAH RUMAH TANGGA UNTUK PENGENTASAN KEMISKINAN DI JATI PULO, JAKARTA BARAT
Authors: Darmoyo Syarief , Sustaningrum Rakhdiny , Sanie-Herman Susy Y.R.
Published: April 2022

A Poverty and healthy life style are part of social problems and become global concern. By cooperating with Jatipulo subdistrict on RW 08 in West Jakarta, lectures and students held the Organic Composing Fertilizer and Marketing Training. The training involved local housewives, local youth committee, and some head of RT. The aims of the activity were to manage the house waste (wasted rice, vegetables) to be processed into organic fertilizer and expected to help the locals and to reduce the house waste by selling the organic composing fertilizer combines with ornamental-plant. There were 60 participants in total attending the training. The training was held on October 14 and November 13 2018 with the evaluation afterwards. The training method was presenting the demonstration and hands-on practical to understand deeply. Te result of evaluation were organic compos successfully implemented and the pot was produced with the current trend design in order to attract millennial customers.
Truth in medicine
Authors: Mihailo Luković , Katarina Majstorović , Dunja Knežević
Published: April 2022

Truth must be the starting point of any definition in medicine and therefore in medical ethics. The space-time definition of the human body and the continuity of the process in it is the first obstacle in medicine on the path to truth, and we immediately encounter this when we try to determine the state of health of patients. The second obstacle lies in the very definition of the concepts of health and disease, which in the end mutually define each other. The desire to penetrate into the continuity of processes in the body is in fact the desire for absolute truth. That which provides existence has an insider (internal, representative) approach to truth. The need to have complete control over the truth in medicine must sometimes end in faith or self-evidence. Philosophy accepted this a long time ago and for the sake of ethics, in the light of a scientific approach to medicine, it is necessary to constantly revise our views.
Конечная бесконечность и бесконечные ряды
Authors: Тимошенко Юрий
Published: April 2022

Определения: прямая, безразмерная точка, бесконечность. Новые способы суммирования расходящихся рядов. Введение новых функциональных рядов, отсутствующих в математических базах
Experimental and natural fossilization of modern viruses
Authors: Belyaev Anatoly , Yukhalin Paul
Published: April 2022

Despite the diversity of viruses and the role they played in the evolution of the biosphere, their genesis is not clear, since the fossilized remains of viruses have not yet been found in ancient rocks. This is due to the fact that, in essence, viruses were tiny protein capsules that, after death, experienced post-mortem transformations - lysis (dissolution) or collapse.
Sociocultural analysis of socio-political systems: methodological foundations of the study
Authors: Karpova N. V.
Published: April 2022

This article provides a methodological study of the eﬀectiveness and potential application of sociocultural analysis in the research of socio-political systems the functioning and the development.

The author turns to the theoretical foundations of the sociocultural approach, examines its speciﬁcity and integrative nature, and also analyzes the problem of compatibility of the sociocultural approach with the structural functionalism methodology. It is shown that such “methodological union” does not form a contradiction in the study of socio-political systems. On the contrary, this integration allows to include in the focus of research the dynamic features of both institutional and noninstitutional aspects of social life, which helps to fully reveal the possible inﬂuences from the subjective grounds on the nature of the evolutionary development of socio-political systems. The use of the sociocultural approach is also being justiﬁed by author by the fact that here the subjective determinants of the functioning of socio-political systems are not limited to the framework of political culture, since the speciﬁcity of a particular system is also inﬂuenced by the civilizational characteristics of the state, the genetic foundations of national cultures, and religion.

Also, the basic methodological principles of sociocultural analysis, which are most relevant for the study of various socio-political systems, are being stated and considered. Among them, special attention is paid to the principle of socio-cultural balance, indicating the permissible possibilities of evolution of each socio-political system and the need for a balance between cultural traditions and structural changes to ensure its sustainable development.
On XV International Scientiﬁc Conference “Sorokin Readings: Contemporary society under condition of socio-economic uncertainty”
Authors: Editorial Article
Published: April 2022

Current article is an overview of the XV International Scientiﬁc Conference “Sorokin Readings”, that took place on March 4, 2021 at the Faculty of Sociology, Lomonosov Moscow State University.
Investigação policial e limites do agente infiltrado nas organizações criminosas
Authors: Bison Karla Stange , Bueno Mariza Schuster , Paula Alan Pinheiro de
Published: April 2022

O presente artigo visa analisar o método investigativo de infiltração policial em organizações criminosas e os limites que devem ser impostos aos agentes enquanto infiltrados, uma vez que a não observância dos limites impostos pode acabar prejudicando e causando nulidades ao processo criminal que se utilizar das provas assim obtidas. Ainda, analisa-se os aspectos legislativos, as primeiras e mais conhecidas organizações criminosas nascidas no Brasil e outros métodos de investigação trazidos pela Lei n. 12.850/2013. Assim, questiona-se: Quais os limites impostos ao agente infiltrado para a obtenção de provas lícitas? No que se refere à metodologia, utiliza-se o método dedutivo, através da técnica de pesquisa bibliográfica, com base na legislação pertinente e doutrinas.
Changing and challenging dimensions of principal autonomy in South Australia: A lived experience phenomenological analysis of the courage to care
Authors: Bills Andrew , Howard Nigel , Bell Michael
Published: April 2022

This paper employs critical policy historiography of South Australian public education as a contextual backdrop that speaks to a hermeneutic phenomenological study of the lived experiences of two former public-school principals, who describe how their ongoing social justice schooling agendas in public education met with considerable departmental resistance. Both resigned at the peak of their public education careers to pursue their schooling vision in the federally funded independent school system which traditionally catered for the wealthy, elite schools and forms the third tier of the complex funding arrangements of education in Australia that has festered for years under the label “the funding wars” (Ashenden, 2016). Changes to funding arrangements opened up the system and gave the opportunity for our two principals to pursue a public vision in the independent schooling sector, free from what they described as the “shackles” of bureaucratic command and control. The phenomenological essence of their journeyed leadership narratives reveals the courage to care, driving their narrative reflections. They perceived that increasing demands of departmental compliance took them away from being able to pursue a socially just vision with autonomy and freedom. Stepping into the uncertainty of their new independent schooling aspirations, the principals felt professional relief and found real autonomy. We conclude with an exploration of the phenomenological notion of “the courage to care.”
Various clinical presentations of uveitis associated with durvalumab treatment
Authors: Vrabic Nika , Fakin Ana , Mekjavic Polona Jaki , Janzic Urska , Vrankar Martina , Valentincic Natasa Vidovic
Published: April 2022

Background

Immune checkpoint inhibitors (ICI) are becoming increasingly common in treating several cancer types. Durvalumab is a human IgG1 monoclonal antibody that blocks PD-L1 binding to PD-1 and CD80 and has recently been approved for the treatment of extensive-stage small-cell lung cancer (ES-SCLC) and locally advanced unresectable (NSCLC). The present review aimed to analyse immune-mediated uveitis, secondary to durvalumab treatment, through a review of the literature and a presentation of two clinical cases.

Patients and methods

A literature review using PubMed search was conducted to identify cases of uveitis secondary to durvalumab and cases of uveitis with optic disc oedema secondary to ICI use that were reported prior to November 14, 2021. Additionally, we report two cases of uveitis consequent on durvalumab treatment.

Results

Five cases of uveitis secondary to durvalumab use were identified in the literature. Anterior, posterior uveitis and vasculitis were reported. Additionally, we present a case of bilateral intermediate uveitis with bilateral optic disc oedema and a case of bilateral posterior uveitis. Our further search revealed 12 cases of uveitis with optic disc oedema secondary to ICI use, with the majority of cases reported secondary to PD-1 inhibitors.

Conclusions

Rarely reported, uveitis secondary to durvalumab can present various clinical pictures and requires a thorough diagnostic workup. Once the diagnosis is established, treatment, commonly with a local or systemic corticosteroid, should be adapted to the severity of the inflammation.
Modifikasi Peta Permainan Bertema Dungeon Crawler Menggunakan Algoritma Genetika Dengan GMS2
Authors: Satria Vinza Hedi , Anggraeny Fetty Tri , Atmaja Pratama Wirya
Published: April 2022

Gim atau permainan digital ( Video Game ) memiliki berbagai macam aspek yang mempengaruhi didalamnya, aspek-aspek ini seperti gameplay, visual, story dan banyak aspek lainnya. Dalam tema permainan tertentu, terkadang sebuah aspek lebih menonjol daripada aspek lainnya. Dungeon Crawler adalah tema gim yang menonjolkan aspek gameplay nya berupa petualangan yang berbeda-beda selama permainan, sebuah kesulitan baru pada sisi pengembang gim ( Developer ) saat hendak mengembangkan sebuah gim Dungeon Crawler. Dikarenakan gim lebih mengutamakan aspek petualangan, developer diharuskan menciptakan banyak area permainan agar pemain tidak bosan, sedangkan bila diharuskan merubah satu-per-satu akan memakan waktu yang lama, untuk itu diperluhkan cara untuk membuat sebuah area berubah-ubah bentuknya. Pada akhir penelitian ini di ajukan sebuah cara melakukan modifikasi peta gim Dungeon Crawler menggunakan algoritma optimisasi, Genetika.Selain aplikasi, rumus yang digunakan juga akan dibuktikan dengan melakukan modifikasi terhadap rumus
Formation of a single information space in the context of the digital transformation of machine-building holding
Authors: RYBAKOV Mikhail B.
Published: April 2022

Subject. The article considers the development of approaches to the integration of digital technologies into production processes of industrial enterprises to improve operational efficiency. Objectives. The purpose is to develop a mechanism for digital transformation of a machine-building holding in relation to the formation of a single information space based on modern approaches to business process reengineering. Methods. I apply methods of systems and economic analysis, modeling of business processes of enterprises. Results. The key factor in the formation of positive effects of digital transformation of industrial enterprises is the integration of business processes within a single information environment. The result of automation of key processes of products’ life cycle within the framework of a single digital platform will be the replacement of "patchwork" automation in disparate information systems of enterprises with integrated monitoring and life cycle management systems, operating on the basis of a single information space. Conclusions. The introduction of "seamless" information exchange based on a single information space is urgent for holding structures characterized by heterogeneous and poorly compatible information systems. The integration of systems of development, modeling, management, and analytical processing based on digital twins, the introduction of augmented and virtual reality tools, and the use of artificial intelligence elements for production management are a necessary stage for the formation of new methods of technological preparation and organization of production, and for the creation of a full-fledged digital twin of production and product life cycle processes.
Non-tax revenue planning
Authors: TAIROVA Svetlana S.
Published: April 2022

Subject. The article considers the planning of non-tax revenue collection.
Objectives. The aim is to reveal reasons that affect the quality of non-tax revenue planning, identify risks in the planning.
Methods. I employ methods of analysis, synthesis, collaboration, concretization, and comparison.
Results. The comprehensive analysis of the system for planning the collection of non-tax revenues unveiled the need to amend the existing regulations used by government authorities to forecast non-tax revenues. The paper proves that implementation of methodological recommendations for budget revenues forecasting failed to improve the quality of non-tax revenues forecasting; reveals incorrect calculation of quality indicator of revenue planning that is used to control the quality of financial management. The paper also identifies the elements of risk management in the planning of non-tax revenues collection.
Conclusions. The elimination of identified causes will enable the government authorities and chief revenue administrators to improve the quality of non-tax revenue planning.
The system of statutory regulation of accounting and reporting in the public sector of Russia
Authors: CHERTKOVA Anastasiya V.
Published: April 2022

Subject. This article explores the issues of reforming accounting and reporting in the public sector of Russia, statutory regulation, and systematization of current rules.
Objectives. The article aims to develop an up-to-date system of statutory regulation of accounting and reporting in the public sector of Russia.
Methods. For the study, I used a comparative analysis.
Results. Based on the analysis of approaches to the systematization of elements of statutory regulation of accounting and reporting in the budgetary sphere, the article proposes an author-developed system of statutory regulation on the basis of the subject of regulation, taking into account the application of international rules.
Conclusions. The presented system of statutory regulation is developed on the basis of the current provisions. International rules provide a framework for reform in the public sector and take a separate position.
Realizing the opportunities of non-fungible token use in the modern intellectual property market
Authors: UMAROV Husan S.
Published: April 2022

Subject. This article discusses the issues of using the capabilities of non-fungible tokens (NFT) to tokenize copyright objects, and regulation of authorship and ownership of NFT objects on existing Internet platforms.
Objectives. The article aims to describe the main opportunities and complexities of tokenization of assets using non-fungible tokens in Russia and abroad, and substantiate the need for legal changes in NFT regulation.
Methods. For the study, I used the methods of comparison, observation, classification, and analysis of statistical data from leading analytical platforms and blockchain explorers, and Russian and foreign research materials.
Results. Based on the assessment of the legal status of non-fungible tokens in Russia and abroad, the article presents legal initiatives to regulate non-fungible tokens both in Russia and abroad.
Relevance. The presented NFT tools can be useful for analysts, researchers, specialists in blockchain technology, journalism, film industry, business, mass events, as well as developers, artists, musicians, art historians and ordinary users in establishing the authenticity of art objects and collectibles, implementing applications, patents, certificates and licenses for the product, tokenizing digital goods to prevent fraud and plagiarism, and monitor the execution of financial transactions.
Toxic pneumonitis induced by trastuzumab as a potentially fatal event: a case report
Authors: Fontes Raquel , Rodrigues Jorge , Oliveira Camila , Peixoto Mauricio , Fernandes Ricardo , Queiroz Luisa , Portela Catarina , Almeida Marta , Nabiço Rui
Published: April 2022

Background:

Trastuzumab is a widely used and well-tolerated drug. Pulmonary toxicity has been described; however, the low incidence, the variability at presentation, and the nonspecific characteristics often make it an exclusion diagnosis.

Case presentation:

We present the case of a 62-year-old women admitted to our service with fever and shortness of breast after treatment with trastuzumab. From the study performed, no other cause was found to explain the event and the patient kept worsening until the diagnosis was established.

Conclusion:

Although pneumonitis is a rare side effect of trastuzumab administration, early recognition and appropriate therapy are crucial and may be lifesaving.
Neurological diseases at the Pediatric Neurology Clinic in a semi-urban Nigerian tertiary hospital
Authors: Akodu Olufemi , Ogunlesi Tinuade , Adekanmbi Abiodun , Gbadebo Fatai
Published: April 2022

Neurological diseases in children may be associated with mortality and long-term morbidity when they recover from acute ailments. The pattern of neurological disorders in an outpatient service may highlight the burden of these diseases. The objective of the present study is to describe the pattern of neurological disorders at the Pediatric Neurology Clinic of Olabisi Onabanjo University Teaching Hospital (OOUTH), Sagamu, Nigeria. A retrospective analysis of consecutive patients in a Pediatric Neurology Clinic of OOUTH, from 1st January 2011 till 31st December 2014, was carried out. A total of 4,476 patients attended the pediatric outpatient unit. Of these, 433 children had neurological disorders with a prevalence of 9.67%. The most frequent pediatric neurological disorders included seizure disorders (37.7%), cerebral palsy (37.7%), and central nervous system infections with complications (6.2%). The subjects with cerebral palsy were the youngest, while the subjects with seizures were the oldest. This study emphasizes that neurological disease contributes substantially to childhood morbidity in a semi-urban African tertiary hospital.
Incorporation of immunohistochemistry in the assessment of survival and prognosis of endometrial cancers: Are we ready for the change?
Authors: Kaur Satinder , Nandwani Megha , Garg Hemlata , Aiyer Hema Malini , Aggarwal Prachi
Published: April 2022

Objectives:

The aim of the study was to determine the mismatch repair (MMR) proteins and p53 expression by immunohistochemistry in operable endometrial carcinoma (EC) patients. The study aimed to analyze and correlate clinicopathological factors and survival with MMR and p53 immunohistochemistry markers.

Material and Methods:

A retrospective cohort study of 115 cases of carcinoma endometrium who underwent primary surgery in our hospital from July 1, 2013, to December 31, 2020, with a minimum follow-up of 1 year. Available tissue blocks were stained for IHC expression of MMR and p53 proteins. Patients were stratified into Type I and Type II on basis of histopathology. Clinicopathological factors, overall survival (OS), and disease-free survival (DFS) were then compared on the basis of MMR deficiency and p53 status.

Results:

The mean age of study population was 58.9 years with a mean body mass index of 31.61 kg/m2. The mean follow-up was 41.29 months. Ninety-seven patients underwent IHC staining for MMR and p53 proteins. Among these 97 patients, 79 patients belonged to Type I histopathology and 18 patients belonged to Type II histopathology. The 79 patients of Type I histopathology were further divided into MSS or microsatellite stable group and MSI or microsatellite instable group. MMR deficit status was seen in 17 (21.5%) patients and 62 (78.5%) patients were MSS. For the 18 cases of Type II ECs, 5 (27.8%) patients were p53 positive whereas 13 (72.2%) patients were p53 negative. For patients with Type I histopathology; the clinicopathological factors such as stage, age, grade of the tumor, lymph-vascular space involvement, lymph node status, and myometrial invasion were compared between the MSI and MSS groups. Patients with microsatellite instability were more likely to present with a higher grade, a positive lymph node status, and with lymph-vascular space invasion. The OS and DFS are not significantly affected in patients with loss of MMR proteins. Due to a smaller number of cases in p53 group, clinicopathological features and survival could not be compared.

Conclusion:

Analyzing of immunohistochemistry status for evaluating the microsatellite instability in patients with Type I endometrioid adenocarcinomas is an alternative and efficient tool in predicting the prognosis for these patients. Further studies with more sample size can help us in studying the impact of MSI and p53 on OS and DFS and for guiding in the management of the same.
Reconfiguring for Agility: Examining the Performance Implications of Project Team Autonomy through an Organizational Policy Experiment
Authors:   University of Pittsburgh, Ramasubbu Narayan , Bardhan Indranil R ,   University of Texas at Austin
Published: April 2022

Agile software development, a paradigm that emphasizes project team autonomy and the value of responding to changes over following standardized processes, has gained prominence in the software industry. Prior investigations on the adoptions of agile paradigms for software operations and their performance implications have typically focused on isolated aspects of software development processes. In this study, we adopt a configurational perspective of software operations and assess the causal impacts of adopting an organizational policy that grants higher levels of autonomy to project teams. Building on the equifinality framework proposed in organizational studies, we posit that an organizational policy that provides higher levels of autonomy for software teams engenders performance-enhancing adaptations through agile reconfigurations of project operations. To test our hypothesis, we collaborated with a commercial software firm and collected data from a policy experiment at the firm. We examined project-level data spanning a four-year observation period during which the firm implemented a new policy that significantly reduced the hurdles for project teams to autonomously reconfigure their operations. The results support our postulation and shed light on how an organizational policy that provides greater autonomy to software
An Empirical Examination of the Economics of Mobile Application Security
Authors:   George Mason University, Sanyal Pallab , Menon Nirup ,   George Mason University, Siponen Mikko ,   University of Jyväskylä
Published: April 2022

The growth of mobile devices coupled with advances in mobile technologies has resulted in the development and widespread use of a variety of mobile applications (apps). Mobile apps have been developed for social networking, banking, receiving daily news, maintaining fitness, and job-related tasks. The security of apps is an important concern. However, in some cases, app developers may be less interested in investing in the security of apps, if users are unwilling to pay for the added security. In this paper, we empirically examine whether consumers are less willing to pay for security features than for usability features. In addition, we examine whether a third-party certification of security features makes customers more willing to pay for security. Furthermore, we investigate the impact of risk perceptions on the willingness to pay for security. To explore these issues, we conducted a scenario-based experiment on mobile app users. Results from our analyses show that consumers are indeed less likely to pay for security features than usability features. However, the likelihood of paying for security features can be significantly increased by third-party certification of the features. Based on our analysis, we offer insights to producers of mobile apps to monetize the enhanced security features of their apps.
Leveraging Multisource Heterogeneous Data for Financial Risk Prediction: A Novel Hybrid-Strategy-Based Self-Adaptive Method
Authors:   Hefei University of Technology, Wang Gang , Chen Gang ,   Fudan University, Zhao Huimin ,   University of Wisconsin-Milwaukee, Zhang Feng ,   Hefei University of Technology, Yang Shanlin ,   Hefei University of Technology, Lu Tian ,   Carnegie Mellon University
Published: April 2022

Emerging phenomena of ubiquitous multisource data offer promising avenues for making breakthroughs in financial risk prediction. While most existing methods for financial risk prediction are based on a single information source, which may not adequately capture various complex factors that jointly influence financial risks, we propose a hybrid-strategy-based self-adaptive method to effectively leverage heterogeneous soft information drawn from a variety of sources. The method uses a proposed new feature- sparsity learning method to adaptively integrate multisource heterogeneous soft features with hard features and a proposed improved evidential reasoning rule to adaptively aggregate base classifier predictions, thereby alleviating both the declarative bias and the procedural bias of the learning process. Evaluation in two cases at the individual level (concerning borrowers at a P2P lending platform) and the company level (concerning listed companies in the Chinese stock market) showed that, compared with relying solely on hard features, effectively incorporating multisource heterogeneous soft features using our proposed method enabled earlier prediction of financial risks with desirable performance.
ДОКАЗАТЕЛЬСТВО ЭКВИВАЛЕНТНОСТИ ПОТОКОВОГО ПРОПАГАТОРА И СУММАРНОГО ОТНОСИТЕЛЬНОГО СМЕЩЕНИЯ МОЛЕКУЛ ФЛЮИДА В ПОРИСТЫХ СРЕДАХ
Authors: Клименок К.Л. , Динариев О.Ю.
Published: April 2022

В работе детально обсуждается факт совпадения потокового пропагатора, полученного методом ядерного магнитного резонанса, и суммарного относительного смещения пассивной примеси; приведено его теоретическое обоснование. Рассмотрены условия, при которых этот вывод сделан, и продемонстрирована его экспериментальная невыполнимость ввиду процессов релаксации намагниченности во флюиде.
PROBLEMS AND RESULTS OF BREEDING RESEARCH OF THE CULTURE OF NICOTIANA TABACUM LIN.
Authors: Хомутова С.А.
Published: April 2022

В результате многолетних исследований на основе комбинационной селекции, различных схем гибридизации и многократных отборов селекционерами института создан широкий спектр сортов табака, отвечающих требованиям ресурсосберегающих технологий. Новые сорта обладают оптимальным вегетационным периодом, быстрым темпом роста растений, интенсивным типом и сбли- женным периодом созревания листьев, сохраняя при этом высокую урожайность и качество сырья.
APPLIED ASPECTS OF COMPUTER SCIENCE IN BACHELOR’S EDUCATIONAL PROGRAM IN A TECHNICAL UNIVERSITY
Authors: Графский О.А. , Данилова Е.В. , Лебединская И.П. , Пономарчук Ю.В.
Published: April 2022

В статье рассматриваются аспекты прикладного характера в подготовке бакалавров направления 09.03.01 «Информатика и вычислительная техника» по профилю «Системы автоматизированного проектирования» при изучении курса информатики и прохождении учебной практики. Поскольку бакалаврам в указанном профиле подготовки необходимо оперировать геометрическими моделями с применением информационных технологий, то в данной статье рассматриваются основополагающие аспекты геометрического характера с применением математического пакета прикладных программ Maple.
THE INHIBITORY EFFECT OF RHODANINE ON THE UNCOATING OF ECHOVIRUS 11 AND A DYNAMIC MODEL FOR THE ANALYSIS OF SINGLE CYCLE GROWTH CURVES
Authors: Усольцева П.С. , Новоселов А.В. , Резайкин А.В. , Сергеев А.Г. , Алимов А.В.
Published: April 2022

Экспериментально установлено влияние роданина на форму графика инфекционной активности в одиночном цикле репродукции эховируса 11 серотипа в культуре клеток RD. Выявлено более выраженное ингибирующее действие роданина на процесс депротеинизации гемагглютинирующего клона эховируса 11 по сравнению с негемагглютинирующим клоном. Представлена динамическая модель ин- терпретации графиков одиночного цикла репродукции эховирусов, позволяющая проводить сравни- тельный анализ задержки интернализации, интенсивности депротеинизации и эффективности синтеза новых вирионов.
MARCHES OF MESO-MACROTIDAL ESTUARIES ARCTIC ZONE AS SOURCE OF SOLUBLE ORGANIC NITROGEN FOR WATER ECOSYSTEMS
Authors: Мискевич И.В. , Чульцова А.Л. , Мосеев Д.С.
Published: April 2022

При исследованиях приливных эстуариев Белого и Баренцева морей обнаружен дополнительный природный источник поступления в устьевые воды растворенных соединений органического азота. Его появление можно связать с деятельностью ризосферных бактерий азотфиксаторов на участках с наличием обширных зарослей галофитов, где концентрации органического азота на порядок превы- шают его величины в речных и морских водах.
INVESTIGATION OF THE PRODUCTION FUNCTIONS OF BLAST FURNACE PROCESS
Authors: Мохсен Х.М. , Барбасова Т.А.
Published: April 2022

ИССЛЕДОВАНИЕ ПРОИЗВОДСТВЕННЫХ ХАРАКТЕРИСТИК ДОМЕННОГО ПРОЦЕССАДанная статья посвящена построению производственных характеристик доменного процесса. Рассмотрена модель управления доменным процессам. Рассматривается повышение производительности доменной печи. Рассмотрено влияние газо-дутьевого режима производительности печи за счет оптимального ведения доменного процесса в реальном времени. Представлены экспериментальные зависимости производительности доменной печи, экспериментальные зависимости удельного расхода кокса от параметров газо-дутьевого режима. Приведены полученные расчетные значения коэффициентов базовой зависимости.
ANALYSIS OF DISTRIBUTION OF ACTIVE GAS IN A REACTOR DURING THE PLASMACHEMICAL ETCHING
Authors: Сагателян Г.Р. , Грачев И.Ю. , Бугорков К.Н.
Published: April 2022

Исследовано распределение активного газа в реакторе установки плаз-мохимического травления на основе решения уравнения диффузии при граничных условиях Неймана и Дирихле с применением программного приложения MATLAB PDE Toolbox.
MATHEMATICAL MODELS FOR PREDICTING THE MAIN CHARACTERISTICS OF THE FUNCTIONING OF AIR TRANSPORTATION SYSTEMS
Authors: Резчиков А.Ф. , Спиридонов А.Ю. , Кушников В.А. , Иващенко В.А.
Published: April 2022

В статье разработаны математические модели, используемые для прогнозирования основныххарактеристик функционирования авиационных транспортных систем. В основу математическихмоделей положен системно-динамический подход, позволяющий на различных временных интервалахопределить основные характеристики авиационной транспортной системы. Приведен пример использования разработанного математического обеспечения.
NATURAL SORBENTS FOR THE PREVENTION OF MYCOTOXICOSES
Authors: Былгаева А.А.
Published: April 2022

Микотоксикозы ежегодно причиняют большие затраты при выращивании молодняка сельскохозяйственных животных, как наиболее чувствительных к патогенному и токсигенному действиюмикроскопических грибов. Кроме того, создают реальную угрозу населению, как потребителю продукции животноводства, загрязнением токсинами – метаболитами микроскопических грибов. В статьерассмотрены характерные свойства микотоксинов загрязняющих растительные корма для сельско-хозяйственных животных, их патогенное влияние на организм сельскохозяйственных животных и существующие меры борьбы и профилактики с микотоксикозами в России. Одним из перспективныхнаправлений в профилактике микотоксикозов животных является использование природных сорбентов, таких как глина, торф, цеолиты, уголь и т.п. Приведены их классификация, механизм взаимодействия сорбентов с микотоксинами. Рассмотрены также положительные свойства сорбентов какиммуностимулирующие, адаптогенные, пролонгирующие, широко используемые в различных областяхсельского хозяйства. Представлены результаты научно-хозяйственного опыта на молодняке крупногорогатого скота, с использованием адсорбированного на цеолите Хонгурине штаммов Bacillus subtilis«ТНП-3» и «ТНП-5» и при одновременном скармливании молодняку естественно контаминированногоплесневыми грибами сена, в условиях Центральной Якутии. Установлено улучшение иммунобиологических процессов в организме (повышение бактерицидной и снижение лизоцимной активности, альбуминовой и β-глобулиновой фракций сыворотки крови), кроме того, происходит коррекция кишечноймикрофлоры, путем увеличения количества представителей нормофлоры – лактобактерий. Тогда какв опытной группе молодняка крупного рогатого скота, установлены признаки дисбактериоза: увеличение количества потенциальных энтеропатогенов и снижение количества представителей нормальной микрофлоры. Изучение биохимических показателей сыворотки крови, показало также увеличение содержания макроэлементов, что необходимо организму молодняка в период активного роста и развития. Таким образом, использование природных сорбентов при профилактике микотоксикозов молодняка крупного рогатого скота в условиях Центральной Якутии, показало хороши результаты, а адсорбированные на нем штаммы Bacillus subtilis, усилили и одновременно улучшили корректирующие, адаптогенные, токсигенные свойства цеолитов.
FEATURES OF MINERAL AND CHEMICAL COMPOSITION OF FERROMANGANESE CONCTRETIONS OF MARINE AND OCEANIC ORIGIN
Authors: Дарьин А.А.
Published: April 2022

Изучены вещественные составы проб железо-марганцевых конкреций (ЖМК) Тихого океана мес-торождения Кларион-Клиппертон и ЖМК Балтийского моря. Приведены результаты исследованийповедения компонентов ЖМК при сульфатизирующем обжиге.
INTERPOLATION OF BEAMS WITH THE APPLICATION OF INFORMATION TECHNOLOGIES
Authors: Графский О.А. , Спивак Е.Р. , Суриц В.В.
Published: April 2022

В статье рассматривается возможность геометрического моделирования обвода коникамис применением математического аппарата матричной алгебры и пакета программирования Maple,которые применяются при обучении студентов по направлениям: «Информатика и вычислительнаятехника», «Прикладная информатика (в дизайне).
A NEW PRINCIPLE OF JET TRUST WHEN MOVING MISSILES
Authors: Петров Ю.И. , Морозов И.И. , Дансюрюн Д.Х.
Published: April 2022

В статье рассматривается новый возможный принцип реактивного движения. Расчеты показывают, что вершина тонкого конического стального стержня под действием механического соударения может отколоться и двигаться со скоростью, многократно превышающую максимальную достигнутую тягу в двигателях сгорания жидкого топлива. Эксперименты по поломке игл в принципесвидетельствует о возможном использовании явления откола для создания маршевой ракетной тяги.Вопрос заключается в практической реализации этой идеи. Например, можно сделать двигатель в виде вращающегося цилиндра с пазами, заполненными усеченными клинообразными стальнымистрежнями. Стержни должны соударяться с неподвижными клиньями. Приведенные расчеты хотяи являются достаточно показательными, но носят ориентировочный характер.
CHARACTER OF CHANGES OF CHEMICAL COMPOSITION OF TOBACCO RAW MATERIAL AND TOBACCO SMOKE AT STORAGE OF CIGARETTES IN DIFFERENT CLIMATIC TERMS (reviewed)
Authors: Остапченко И.М. , Покровская Т.И. , Еремина И.М. , Галич И.И.
Published: April 2022

Для выполнения раздела V Технического регламента Таможенного союза на табачную продукцию (ТР/ТС 035/2014) «Требования к табачной продукции» изучаются закономерности влияния сроков и усло вий хранения различных видов сигарет на содержание токсичных компонентов в табачномдыме, на дегустационные и курительные свойства.
STUDY OF INFLUENCE OF PLACEMENT CONDITIONS OF EPIPHYTIC MOSSES ON THE CHEMICAL ELEMENTS CONTENT WITH ACTIVE MONITORING
Authors: Рогова Н.С. , Рыжакова Н.К. , Борисенко А.Л. , Кабанов Д.В.
Published: April 2022

В работе обсуждаются проблемы, возникающие при использовании активного биомониторинга.Предложен метод мониторинга с использованием вертикально размещенных планшетов и эпифитного мха Pylaisia polyantha. Изучено влияние высоты, ориентации планшетов и вида дерева, на корукоторого крепится планшет, на содержание химических элементов во мхах.
MODELLING AND CALCULATION OF THE STRAINED AND DEFORMED CONDITION OF PRESSURE HEAD TUNNELS IN THE MASSIF NEAR THE RIVER CANYON
Authors: Баялиева Ж.А. , Ботоканова Б.А. , Жумабаев Б.
Published: April 2022

В статье дано закономерности распределения напряжений вокруг туннелей овальным или треугольными поперечными сечениями, когда туннель находится под напором воды и в зоне влияния речногоканьона.