bluuebunny/crossref_metadata_2025 huggingface dataset:
Scrambled RGD hexameric peptide hydrogel supports efficient self-assembly and cell activity
Authors: Al Taief Karrar , Nemec Stephanie , Middleton Isis , Kilian Kristopher , Thordarson Pall
Published: November 2024

Amino acid sequence is crucial in controlling peptide-based hydrogel formation, whereby changing the position of a single amino acid can significantly alter the gel’s properties. Herein, we report the gelation kinetics and cell viability of scrFmoc-GFFRDG (where we have scrambled the RGD-based gel hexapeptide; Fmoc-GFFRGD). The scrambled sequence showed improved gelation properties compared to the original Fmoc-GFFRGD sequence with scrFmoc-GFFRDG forming a gel in under 10 minutes, significantly faster than the 2-hour gelation time, and at a concentration eight times lower than the original Fmoc-GFFRGD sequence. We also examined the combination of the two gelators in a ratio of 1:1, final concentration of 0.4% (w/v). Interestingly, the stiffness of hybrid hydrogel was ~3 kPa, whereas individually, neither gelator at the same concentration exceeded 0.5 kPa. The cell-adhesion motif RGD improves the ability of the peptides to promote attachment of cells due to integrin recognition. However, when fibroblasts were cultured on the hydrogels, the scrFmoc-GFFRDG yielded a higher level of alpha-SMA expression in cells than those cultured on Fmoc-GFFRGD, suggesting a microenvironment conducive to myofibroblast transitions. This study provides a new outlook on how a well-known scrambled peptide motif (RDG) can fine-tune hydrogel assembly and cell culture applications.
Deciphering Atomic Polarizability: The Absolute Radii and Orbital Contributions Visited
Authors: Khatiwada Richa , Li Pengfei
Published: November 2024

Polarizability is a fundamental property in molecular sciences. It depends on the atom and molecule size and characterizes how ease of deforming the electron cloud by an electric field. Previous studies suggested that the electronic distribution of the outmost orbital can be used to determine the ground state properties of the atom like hardness, polarizability, and electronegativity. Additionally, the “absolute radius”—the most probable radius of the outermost orbital—has been used to derive atomic properties. In our study, we present a new set of absolute radii for various atoms and ions across the periodic table, calculated using high level quantum mechanical calculations. These radii exhibit greater accuracy compared to those previously derived using Slater shielding constants and could offer enhanced utility for diverse scientific applications. We also calculated atomic polarizabilities for a range of atoms and ions using three different approaches. One method assumes a spherical electron distribution based on the absolute radii, while the other two rely on the radial distribution function of the outermost orbital(s). Comparisons with reference polarizabilities obtained from density functional theory (DFT) indicate that while these strategies provide qualitative insights, they do not yield quantitative agreement. To better understand the factors influencing atomic polarizability, we evaluated the contributions of different orbitals. Interestingly, our results reveal that inner orbitals contribute significantly to polarizability, which are comparable to the outermost orbital. This finding challenges the conventional view of polarizability as solely a volume-dependent property linked to the valence orbital. Instead, polarizability might be better considered as an energetic property arising from the collective contributions of various orbitals.
Improving Drug-Induced Liver Injury Prediction Using Graph Neural Networks with Augmented Graph Features from Molecular Optimisation
Authors: Lee Taeyeub , Posma Joram
Published: November 2024

BACKGROUND. Drug-induced liver injury (DILI) is a significant concern in drug development, often leading to the discontinuation of clinical trials and the withdrawal of drugs from the market due to severe hepatotoxicity. This study explores the application of graph neural networks (GNNs) for DILI prediction, using molecular graph representations as the primary input. METHODS. We evaluated several GNN architectures, including Graph Convolutional Networks (GCNs), Graph Attention Networks (GATs), Graph Sample and Aggregation (GraphSAGE), and Graph Isomorphism Networks (GINs), using the latest FDA DILI dataset and other molecular property prediction datasets. We introduce a novel approach that creates a custom graph dataset, driven by molecular optimisation, that incorporates detailed and realistic chemical features such as bond lengths and partial charges as input into the GNN models. We have named our model approach DILIGeNN. RESULTS. DILIGeNN achieved an AUC of 0.897 on the DILI dataset, surpassing current state-of-the-art model in the DILI prediction task. Furthermore, DILIGeNN outperformed the state-of-the-art in other graph-based molecular prediction tasks, achieving an AUC of 0.918 on the Clintox dataset and 0.993 on the BBBP dataset and 0.953 on the BACE dataset, indicating strong generalisation and performance across different datasets. CONCLUSION. DILIGeNN, without relying on biological data, outperforms the state-of-the-art methods in DILI prediction that incorporate both chemical and biological data. These findings highlight the effectiveness of our molecular graph generation and the GNN training approach as a powerful tool for early-stage drug development and drug repurposing pipeline.
Alumina Supported Iron Catalysts for the Selective Acetylene Hydrogenation under Industrial Front-End Conditions
Authors: Lamers Hannah , Schummer Malte , Lucas Martin , Rose Marcus
Published: November 2024

The removal of acetylene traces from ethylene streams coming from the steam cracker is carried out in the industry on an annual scale of several million tonnes using Pd-Ag/Al2O3 catalysts. The substitution of palladium containing catalysts with more abundant, cheap and non-toxic materials is a first crucial step towards a more sustainable chemical industry. Since iron is one of the most abundant metals and can be mined in almost all regions world wide, it is an ideal catalyst material. In this work, we present the development of alpha alumina supported iron catalysts with 1 wt%, 5 wt% and 10 wt% iron loading and their application in the selective acetylene hydrogenation under industrially applied front-end conditions. The catalysts were prepared via simple incipient wetness impregnation and were analyzed via XRD, XRF, TPR, TEM and N2-Physisorption. The catalysts were subsequently calcined, reduced and tested in the selective acetylene hydrogenation. After an activation phase, the catalysts show excellent activity and selectivity in the acetylene hydrogenation at 90 °C without significant ethylene hydrogenation. The excellent catalytic activity underline the great potential of iron based catalysts as an alternative to conventional Pd-containing materials.
A greener and more scalable synthesis of biogenic polydisulfides from lipoic acid
Authors: Koelbl Christopher , Obunadike Chizoba , Ham Woojung , Mahmud Nadim , Garcia Mathew , Lizundia Erlantz , Worch Joshua
Published: November 2024

Ring-opening polymerization (ROP) of dithiolanes form polydisulfides, an emergent class of dynamic covalent polymers. However, both monomer and polymer syntheses typically require anaerobic and moisture-free conditions, often employing hazardous reagents and solvents that limits scalability and transformation into practical materials. Here, we disclose efficient, scalable syntheses for poly(ethyl lipoate) and ethyl lipoate; these syntheses incorporate Green Chemistry principles. We optimized the synthesis of ethyl lipoate on a 100-gram scale (>80% yield) with an improved Fischer esterification: E-factor = 2.27, an order of magnitude above conventional methods. We used diphenyl phosphate, a non-hazardous commercial organic acid, to yield ultra-high-molecular-weight poly(ethyl lipoate) on a 50-gram scale from cationic ring-opening polymerization (CROP). The polymerizations proceeded under ambient atmosphere in benign solvents that were used as received. We then developed a mild depolymerization strategy to regenerate monomer. Due to their extreme molar masses, these polymers possess unique mechanical and physical properties, which we briefly surveyed by assessing thin films. Life cycle analysis (LCA) conducted on both synthetic processes and polymer recycling show that this dynamic polydisulfide has competitive sustainability attributes. In fact, both processes have similar environmental impacts compared to those of several commodity polymers, despite the latter having a significant efficiency advantage due to economies of scale. These discoveries establish an economical and scalable closed-loop polymer platform that can be broadly applied to various polydisulfides sourced from lipoic acid.
A Graph-Theoretic Framework for Analyzing and Designing Chemical Engineering Curricula
Authors: Lopez Blake , Shao Yue , Zavala Victor M.
Published: November 2024

Topics and courses that compose chemical engineering curricula are interconnected in a complex manner. The organization/structure of chemical engineering curricula closely matches the practice of breaking down chemical processes into fundamental phenomena (e.g., thermo, balances, and transport) and unit operations (e.g., reactors, separators, and heat exchangers). Emergence of modern topics (e.g., sustainability and molecular engineering) and advances in pedagogy call for the analysis and potential re organization of curricula (e.g., use of case studies to foster integration of courses and include new topics/courses in a synergistic manner). In this work, we propose a graph theoretic abstraction to represent, analyze, and reorganize the structure of curricula. In this abstraction, nodes represent topics/concepts, edges represent connectivity/dependencies between topics, and courses can be interpreted as collections of topics that are tightly interconnected (also known as clusters or modules). The abstraction enables the use of algorithms and software tools of graph theory and optimization to formalize the visualization and evaluation of curricula (e.g., identify key topics) and to identify re-organization strategies (e.g., defining strategic modules/courses that maximize topic cohesiveness/connectivity). Additionally, the abstraction can help formalize and facilitate discussions between instructors that might have different priorities/perspectives on curriculum content and organization. We provide case studies that analyze real curricula at the University of Wisconsin-Madison to highlight the benefits of the proposed framework.
Copper-mediated C–C Coupling of Alkenyl Boronates and Bromodifluoroacetates
Authors: Yurov Yevhen , Laniush Kamila , Hryschuk Oleksandr , Liashuk Oleksandr , Grygorenko Oleksandr
Published: November 2024

The reaction of alkenyl boronates and bromo-difluoroacetates in the presence of copper powder and TMEDA as the catalytic system was developed. The corresponding C–C coupling products were obtained in 35–93% yield. The method tolerated a variety of functional groups, namely, phenol, (thio)ether, protected amino-, hydroxy-, ketone, and carboxylic acid moieties, as well as various saturated carbo- and heterocycles, and was compatible with multigram scale up (to 76 g). The diastereoselectivity of the process was typically low, so that ca. 1:1 E/Z isomeric mixtures were formed from pure E or Z alkenyl boronates. Further functional group transformations demonstrated the utility of the prepared compounds as valuable building blocks for synthetic and medicinal chemistry. Based on the obtained results and the literature data, a plausible reaction mechanism was proposed involving the formation of radical and organocopper intermediates.
Red-light Active N,C,N-Pincer Bismuthinidene: Excited State Dynamics and Mechanism of Oxidative Addition into Aryl Iodides
Authors: Stamoulis Alexios , Mato Mauro , Bruzzese Paolo Cleto , Leutzsch Markus , Cadranel Alejandro , Gil-Sepulcre Marcos , Neese Frank , Cornella Josep
Published: November 2024

Despite the progress made in the field of synthetic organic photocatalysis over the last decade, the use of higher wavelengths, especially those in the deep-red portion of the electromagnetic spectrum, remain comparatively rare. We have previously disclosed that a well-defined N,C,N-pincer bismuthinidene (1a) can undergo formal oxidative addition into a wide range of aryl electrophiles upon absorption of low-energy red light. In this study, we map out the photophysical dynamics of 1a and glean insights into the nature of the excited state responsible for the activation of aryl electrophiles. Transient-absorption and emission techniques reveal that, upon irradiation with red light, the complex undergoes a direct S0 → S1 metal-to-ligand charge transfer (MLCT) transition, followed by rapid intersystem crossing (ISC) to a highly reducing emissive triplet state (−2.62 V vs Fc+/0 in MeCN). The low dissipative losses incurred during ISC (~6% of the incident light energy) help rationalize the ability of the bismuthinidene to convert low-energy light into useful chemical energy. Spectroelectrochemical and computational data support a charge-separated excited-state structure with radical-anion character on the ligand and radical-cation character on bismuth. Kinetic studies and competition experiments afford insights into the mechanism of oxidative addition into aryl iodides; concerted and inner-sphere processes from the triplet excited state are ruled out, with the data strongly supporting a pathway that proceeds via outer-sphere dissociative electron transfer.
How Do Perceptions of Zoo Animal Welfare Influence Public Attitudes, Experiences, and Behavioral Intentions? A Mixed-Methods Systematic Review
Authors: Phillips Nicki , Maréchal Laëtitia , Ventura Beth , Cooper Jonathan
Published: November 2024

The public expects zoos to provide high standards of animal care. Failing to meet public expectations can have detrimental impacts on public experiences and behavior, which in turn can compromise zoos’ organizational goals relative to conservation and public education. Despite increased research interest in understanding how the public perceives animal welfare in zoo settings, to date the factors that influence such perceptions are still unclear. To address this gap in knowledge, we conducted a mixed methods systematic review using a PRISMA approach to identify the factors that influence public perceptions of zoo animal welfare and the potential ramifications of these perceptions on public attitudes, experiences, and behaviors. A total of 114 peer reviewed journal articles were analyzed: 43 provided qualitative data for thematic synthesis and 85 reported quantitative data for content analysis. Three main groupings were identified that impacted public perception of animal welfare in zoos: human, animal, and environmental factors. Within the human factors, ethical justifications, direct interactions, and inappropriate visitor behaviors were important. For the animal factors, animals’ behavior, apparent health status, and the suitability of certain taxa for captivity were found to be key. Finally, several aspects of the environment – conditions of the facility, the exhibit, and welfare-related educational material – were influential. Overall, negative perceptions of animal welfare resulted in negative visitor attitudes towards zoos, detrimentally impacted experiences, and lowered likelihood to visit zoos and engagement in conservation efforts. The articles in this review provided valuable insights into the factors affecting public perception of zoo animal welfare; however, future research may benefit from a more structured approach to increase comparability and validity of results across studies. We conclude by proposing seven recommendations to increase the robustness and validity of future research in this area.
ASSESSING DROUGHT DYNAMICS IN NORTHEASTERN ALGERIA USING THE VEGETATION HEALTH INDEX DERIVED FROM MODIS DATA
Authors:   Faculty of Life and Natural Sciences, Department of Agronomy, Echahid Hamma Lakhdar University, El Oued, Algeria, MAYOUF Rabah , HANAFI Mohamed Tahar ,   Laboratory of Biology, Environment and health, Department of Biology, Faculty of Life and Natural Sciences, Echahid Hamma Lakhdar University, El Oued, Algeria,   Scientific and Technical Research Centre for Arid Areas (C.R.S.T.R.A), Omar El Barnaoui, Campus of Mohamed, Khider University of Biskra, 07000, Biskra, Algeria
Published: November 2024

This study focuses on drought monitoring in Tebessa, Algeria, utilizing remote sensing techniques and various drought indices. The research employs data from MODIS (Moderate Resolution Imaging Spectroradiometer) satellites and utilizes the Google Earth Engine (GEE) platform for data processing and analysis. The study area, Tebessa Province in northeastern Algeria, is characterized by an arid to semi-arid climate, making it particularly vulnerable to drought. The research uses three main indices to assess drought conditions; The (VCI) stands for Vegetation Condition Index, the (TCI) for Temperature Condition Index and the (VHI) for Vegetation Health Index. These indices are calculated using NDVI (Normalized Difference Vegetation Index) and Land Surface Temperature (LST) data from MODIS products spanning from 2001 to 2024. The results show varying drought conditions across different periods, 2005-2006 recorded severe dry conditions in the central and southern areas, 2009-2010 recorded extreme drought in the southern region, with moderate to mild conditions in the central zone, for 2022-2023 recorded widespread extreme drought conditions, particularly affecting the central parts. The TCI consistently indicated wet conditions in most years, especially in 2002, 2009, and 2019, highlighting its sensitivity to seasonal temperature variations. The VCI and VHI analyses revealed distinct spatial variations in drought impacts, with central zones being particularly vulnerable. The study observed declining trends in TCI, VCI, and VHI values over time, suggesting worsening drought conditions potentially driven by climate change. This trend could lead to more frequent and severe droughts, further stressing local vegetation. The research confirms the effectiveness of MODIS-derived drought indices, particularly the VHI, in monitoring regional drought dynamics. It emphasizes the importance of these tools for identifying areas at risk of vegetation degradation and predicting potential decreases in crop yields.
Exploring the Research of Green Residential Interior Design under the
Concept of Low Carbon
Authors: Cao Yongxia , Nadia Binti Mohd Nasir
Published: November 2024

With the development of scientific and technological progress and the
gradual improvement of national living standards, people are paying more
attention to the green and low-carbon design of residences, seeking a more
comfortable living environment. The article explores ways to integrate
low-carbon concepts into residential interior design from the perspectives
of spatial design, decorative design, and energy application, which can help
to promote ecosystem balance, minimise resource wastage, and promote the
sustainable development of the construction industry while improving the
level of design.
Ways to Cultivate and Develop Human Resources in the New Situation
Authors: Wang Lei , Yang Gengliang
Published: November 2024

In the trend of globalization, digitization, and economic integration, human resources are the core competitiveness of enterprises, and cultivating and developing them is crucial for enhancing competitive advantages. This article delves into how human resource development drives enterprise innovation, promotes team collaboration, and optimizes performance management. Currently, although many enterprises are beginning to attach importance to human resource development, they still face problems such as insufficient investment, weak targeted training, and insufficient exploration of employee potential. Therefore, it is proposed that in the new situation, enterprises need to strengthen diversified training strategies, use digital tools to improve training efficiency, build a fair performance evaluation system, stimulate employee potential, and promote internal talent mobility. The implementation of these strategies will effectively enhance the efficiency of enterprise human resource management and consolidate market position.
"Research on Traditional Handicrafts and Stratefy of Building Brand Tourism -- Taking Chinese Miao Silver Jewellery Crafts as an Example"
Authors: Jiang Wei Lu
Published: November 2024

Research on Traditional Handicrafts and Stratefy of Building Brand Tourism -- Taking Chinese Miao Silver Jewellery Crafts as an Example
An Analysis of the Correlation between Employee Compensation Policies and Operating Performance of Accounting Firms
Authors: Chia-Chi Lee
Published: November 2024

This paper aims to explore the impact of compensation for employees of different ranks on the overall operating performance of accounting firms (hereinafter referred to as firms) and operating performance of the business markets, and provide reference for decision making by firm managers on employee compensation. The results show that 1) judging by overall operating performance, a firm’s income from professional practice increases as the average annual salary of partner accountants, manager-level heads, professional team heads and professional assistants increases, or the proportion of employees with the CPA qualification rises; the number of cases entrusted to a firm increases as the average annual salary of partner accountants and professional assistants increases, or the proportion of employees with the CPA qualification rises; 2) judging by the operating performance of business markets, the income from tax service, management consulting, business registration and other business lines increases as the average annual salary of partner accountants and professional team heads rises; the income from public issue of certification documents, tax service and business registration and other business lines increases as the average annual salary of professional assistants rises; a higher proportion of employees with the CPA qualification has a positive impact on the income from management consulting; 3) the shorter the firm age, and the greater the firm size, the better the firm’s overall operating performance.
The Role of Social Change Factors in the Criminal Saturation Law
Authors: Xie Shiqing , Yi Xiu
Published: November 2024

In the crime saturation law,the crime rate of a country depends on the specific time and space conditions of the country, and its distribution and size are limited to the "saturation" of social conditions. Therefore, the process of social change is the process of the criminial rate change. First, based on the regression analysis of the longitudinal crime rate data and relevant social development data in China from 1981 to 2015, this paper searches for the cointegration relationship between the variable sequences. Second, by the Quandt-Andrews breakpoint test, this paper finds the potential structural breakpoints within the sample interval. Finally, based on the structural breakpoints, this paper compares and analyzes the regression results between the sub regions, the sub intervals and overall sample intervals. The study finds that the increase of per capita GDP level, the widening income gap between urban and rural areas, the decline of social education level and the increase of unemployment rate all contribute to the growth of crime rate. China’s relevant departments should implement measures to maintain stability in the period of rapid economic growth, pay attention to social equity problems, increase investment in education, and reduce social unemployment rate.
Research on the Development Strategies of Youth Green Entrepreneurship in Sustainable Development
Authors: Han Shengmiao , Badrul Hisham Bin Kamaruddin
Published: November 2024

This article explains the connotation and types of green entrepreneurship, analyzes the shortcomings of green entrepreneurship development among young people from the perspective of sustainable development, and proposes countermeasures to promote green entrepreneurship among young people from multiple aspects, including supporting policies, entrepreneurial facilities, education system, and entrepreneurial fund channels.
Pequenos Lordes: Uma análise da moda infantil masculina da primeira metade do século XX (1905-1958)
Authors: Magno Isabela Brasil
Published: November 2024

Este artigo procura analisar o auge do fenômeno da moda de vestir meninos como “pequenos lordes”, o seu declínio e seu desaparecimento ao longo da primeira metade do século XX. Essa forma de vestimenta ficou conhecida pelo livro infantil Pequeno Lorde, de Frances Hodgoson Burnett. Como fontes para analisar a trajetória desse estilo são utilizadas duas publicações brasileiras: a revista infantil O Tico-Tico e a publicação feminina Anuário das Senhoras, além do próprio livro de Burnett e suas representações no teatro e cinema. Por meia delas, se discutem os padrões de vestimenta infantil (em especial masculino) da primeira metade do século XX e as diversas transformações pelas quais passaram. Como principais referências estão as obras de Philippe Ariès, Jo B. Paolleti e Gilda de Mello e Souza. Por fim, são traçadas reflexões sobre como conceitos como doçura, delicadeza e beleza, que pautavam um ideal de masculinidade infantil nas décadas de 1900 e 1910, foram desaparecendo e sendo suplantados por valores como vigor e bravura.
The Multiple Presentation and Organic Integration of Ideological and Political Elements in the Curriculum: A Case Study of the Course “Theoretical Basis of New Energy”
Authors: Tang Junying
Published: November 2024

With the deepening of higher education reform, the teaching work of new energy theoretical basic courses should be further optimized. Teachers should actively introduce new education concepts and teaching methods, so as to better arouse students’ interest, strengthen their understanding and application of the knowledge, and improve the education effect. As a popular education mode at present, curriculum ideology and politics can greatly enrich the teaching content of new energy theoretical basis in colleges and universities, broaden the path of education, and greatly promote the more comprehensive development of students. In view of this, this paper will analyze the integration of curriculum ideology and politics into the basic teaching of new energy theory in colleges and universities, and put forward some strategies for your colleagues’ reference.
A Brief Discussion on the Construction of Curriculum System of Electronic Information Major in Universities in the Internet Era
Authors: Wang Chaoqun , Song Yutan , Wang Hualu , Zhang Dafu
Published: November 2024

In the background of rapid social and economic development, electronic information technology has become an important force to promote social development. Colleges and universities as important places to train high-quality technical talents, should pay attention to adapting to market changes, timely optimize the personnel training mode, and optimize the construction of professional curriculum system. This paper studies the construction of the curriculum system of electronic information majors in colleges and universities in the Internet era. First, it analyzes the construction of the curriculum system of electronic information technology majors in colleges and universities, and then puts forward corresponding optimization strategies, including the combination of theory and practice, the construction of modular courses, the analysis of vocational post groups, the rationalization of curriculum arrangements, etc. The aim is to cultivate electronic information professionals who have both a solid theoretical foundation and innovative ability and practical skills.
Research on the Teaching Mode of “Cross-border E-commerce” in International Trade Major of Independent College Based on PBL
Authors: Xie Guanhui
Published: November 2024

The Ministry of Education has proposed to accelerate the merger and transformation of independent colleges, and has set new goals for their education and teaching work in cultivating undergraduate applied skilled talents. Independent colleges should take this opportunity to actively promote teaching mode reform. Taking the International Economics and Trade major as an example, in response to the shortcomings of the talent training system and practical teaching, a hybrid teaching model with “cross-border e-commerce” as the characteristic application direction can be proposed. Guided by PBL and students' application results, the information technology and practical elements of the curriculum can be explored, and information technology methods can be integrated into the implementation of “flipped classroom+project-based teaching” and other information technology integrated teaching and teaching evaluation design models.
A Study on the Training Path for College English Majors in the New Era - A Case Study of the Curriculum Reform of Spoken English
Authors: He Chunyan
Published: November 2024

With the development of the social economy, high-quality English talents have become an indispensable part of economic development, and play an important role in foreign trade, education, translation, and other industries. However, the traditional teaching mode of colleges and universities has made it difficult to meet society’s and the industry’s needs for English talents. In the process of training English talents in colleges and universities, there are some problems, such as the inconsistency between the curriculum and the reality, the traditional education mode, and the unclear goal of talent training. Therefore, college English majors need to change the traditional teaching concept and readjust the teaching objectives, curriculum standards, and teaching contents to meet the needs of high-quality English talents under the social and economic development in the new era.
Fatores de risco para lesão por pressão em pacientes em terapia intensiva: revisão narrativa da literatura
Authors: Pinho Soria de Lima Franciane , Sant'Ana Tristão Fernanda , Rodrigues Fonseca Michele , Moraes Dutra Camila , Velleda dos Santos Cibele , Angélica Silveira Padilha Maria
Published: November 2024

Objetivo: Identificar os fatores de risco para lesão por pressão em pacientes adultos em terapia intensiva, buscando atualizar os conhecimentos a respeito do tema. Métodos: Pesquisa exploratória-descritiva, em base de dados documental de natureza qualitativa, selecionados seguindo critérios de inclusão: artigos publicados no período de 2013 a 2023, em idioma português, espanhol e inglês, artigos resultantes de pesquisas realizadas com seres humanos, que abordam fatores de risco para lesão por pressão em pessoas maiores de 18 anos. Resultados: Selecionados 25 artigos, sendo identificados 12 fatores de risco para lesão por pressão, que foram: tempo de permanência na UTI entre 3 e 14 dias, idade entre 42,5 anos a 74,4 anos, sexo masculino, ventilação mecânica mais de 72 horas por mais de 20 dias, escala de Braden com escore variando entre 11 e 18 pontos, pressão arterial média <60mmhg, atrito e fricção, imobilidade, doença cardiovascular, diabetes mellitus, além do uso de medicamentos sedativos e vasopressores. Conclusão: Considerando a alta incidência de LPP em pacientes internados em UTI é necessário a realização de estudos que forneçam informações, para que os profissionais de saúde possam reconhecer os fatores de risco para LPP e implementar ações de prevenção. Os resultados deste estudo indicam alguns fatores de risco que podem ser controlados, ou minimizados a fim de reduzir os riscos de LPP em UTI.
DEVELOPING WORDWALL-BASED LEARNING MEDIA FOR ONLINE BUSINESS SUBJECTS FOR ELEVENTH GRADE STUDENTS AT SMKN 1 SOOKO MOJOKERTO
Authors: Ningrum Ananda Octavia , Sulistyowati Raya
Published: November 2024

This study aims to develop Wordwall-based learning media for Online Business subjects for Eleventh-grade students at SMKN 1 Sooko Mojokerto. This study used ADDIE development model, which includes the stages of Analysis, Design, Development, Implementation, and Evaluation. The subjects of this study were 34 students from the eleventh Online Business and Marketing class at SMKN 1 Sooko Mojokerto. Validation was conducted by three experts: a linguist, a media expert, and a material expert. The validation results showed that the Wordwall-based learning media is highly feasible, with language validation at 82%, media validation at 98%, and material validation at 100%. Therefore, this Wordwall-based learning media is highly suitable for Online Business learning at SMKN 1 Sooko Mojokerto.
THE EFFECT OF TEMPERATURE ON Na, K, AND Ca EMISSION DURING COMBUSTION OF PINEWOOD SAWDUST
Authors: Legonda Isack
Published: November 2024

Quantification of Na, K, and Ca emissions from the combustion of pinewood sawdust has been conducted. The concentration of these metals in both sawdust and ashes was determined using inductive coupled plasma spectrometry. Ash samples were collected at 550 oC and 900 oC to simulate the actual operating conditions for thermal conversion processes which are mainly pyrolysis, gasification, and combustion. Also, tar samples were collected from the pyrolysis process conducted at 500 oC to assess the concentration of selected metals. The analysis results showed that emissions of Na, K, and Ca were found to range from 19-39 ppm, 340-400 ppm, and 500-550 ppm for temperatures between 550 oC and 900 oC respectively. The presence of metal content in tar supports that the emission mechanism can be through adhesion during the volatilization of heavy hydrocarbons from biomass combustion. Thus, the study findings suggest that treatment of metal emissions from the open fire such as that of firewood cookstoves is highly recommended.
Vybrané archeologické doklady válečných událostí z husitského období v severovýchodních Čechách (Bilance možností a limitů výzkumu)
Authors: Drnovský Pavel
Published: November 2024

Text studie přináší bilanci archeologického výzkumu lokalit spojených s dobou husitských válek v severovýchodních Čechách. Představeny jsou možnosti výzkumu areálu polních bitev, polních táborů, zaniklých církevních areálů. Mezi lépe poznané lokality patří situace spojené s obléháním opevněných sídel. Možnost jejich výzkumu se váže na relikty obléhacích prací a zejména na detekci artefaktů spojených s dobýváním fortifikací. Prostorová analýza distribuce militarií může ukázat postup útočníků a směr útoku na opevněné sídlo. Přínosné téma pro zpřesnění datace skupin archeologických nálezů představuje výzkum situací se známým datem zániku, zpravidla spojené s dobytím a neobnovením lokality.
Visualidad y la construcción de estructuras de pensamiento e imaginarios sociales en la virtualidad
Authors: Ortiz Castro Fernando
Published: November 2024

El presente artículo tiene como fin analizar los efectos culturales, generados por el uso de los sistemas de acceso de la información tecnológica, en la construcción de imaginarios sociales, así como en el desarrollo de prácticas de sentido en la contemporaneidad. Específicamente, es de interés para este estudio descifrar y reflexionar, a través de diferentes argumentos teóricos, sobre cómo los procesos de distribución y consumo de imágenes, generadas por los sujetos desde una pantalla, permiten configurar esquemas simbólicos y de control, dentro de esta esfera virtual de interconexión; permitiendo no solo dirigir la mirada, sino configurar también el ethos individual como colectivo.
Mengoptimalkan Material Sisa Menjadi Produk Yang Memiliki Nilai Tambah Menggunakan Metode Redesign (Studi Kasus: ARTI Furniture)
Authors: Fuad Saftrian Mukhlizul , Pratama Randi , Azhari Muhamad Roihan Al , Prabandaru Hanindito
Published: November 2024

Seiring dengan meningkatnya pelanggan dalam penjualan furniture meningkat pula manufaktur produk yang dibuat. dari para pengrajin furniture terutama perusahaan mebel kustom menjadi salah satunya menghasilkan limbah dengan dari sisa kayu. Menghadapi meningkatnya limbah produksi seperti ini, dominan limbah kayu yang dihasilkan akan dibuang karena tidak layak untuk dipakai. hal ini meningkatkan volume limbah yang sekarang sudah menjadi permasalahan yang harus segera diatasi, beberapa jenis limbah kayu bisa diolah kembali namun masih ada beberapa jenis yang belum bisa dibentuk menjadi produk kembali. Dari limbah yang bisa diolah kembali, dengan memanfaatkan  limbah ini bisa memberikan potensi untuk membuat dan merancang produk baru tanpa membutuhkan material baru. hal ini meningkatkan sustainabilitas dari pengrajin furniture dengan tujuan menambah inovasi dalam produksi furniture yang diproduksi dan memanfaatkan limbah.Kata Kunci: sustainable, furniture, SWOT, observasi, design.
Translation of non-technical skills and attitudes to practice after undergraduate interprofessional simulation training
Authors: Webster Craig S. , Verstappen Antonia , Weller Jennifer M. , Henning Marcus A.
Published: November 2024

Introduction: We aimed to determine the extent to which non-technical skills and attitudes acquired during undergraduate interprofessional simulation in an Advanced Cardiac Life Support (ACLS) course translated into clinical work.
Methods: Following ACLS simulation training for final-year nursing and medical students, we conducted a 1-year follow-up survey, when graduates were in clinical practice. We used the Readiness for Interprofessional Learning Scale (RIPLS - higher scores indicate better attitudes to interprofessional practice), and nine contextual questions with prompts for free-form comments. RIPLS scores underwent repeated-measures between-groups (nurses vs doctors) analysis at three timepoints (pre-course, post-course and 1-year).
Results: Forty-two surveys (58% response) were received, demonstrating translation of non-technical skills and attitudes to clinical practice, including insights into the skills and roles of others, the importance of communication, and improved perceptions of preparedness for clinical work. However, RIPLS scores for doctors decreased significantly upon beginning clinical work, while scores for nurses continued to increase, demonstrating a significant interaction effect (reduction of 5.7 points to 75.7 versus an increase of 1.3 points to 78.1 respectively – ANOVA, F(2,76)=5.827, p=0.004). Responses to contextual questions suggested that reductions in RIPLS scores for doctors were due to a realisation that dealing with emergency life support was only a small part of their practice. However, the prevailing work cultures of nurses and doctors in the workplace may also play a part.
Conclusion: We demonstrated the translation of non-technical skills and attitudes acquired in undergraduate simulation to the clinical workplace. However, results are tempered for junior doctors beginning practice.
Application of the ECM algorithm to the estimation of the likelihood function in financial auditing
Authors:   Uniwersytet Ekonomiczny w Katowicach, Katedra Statystyki, Ekonometrii i Matematyki, Sitek Grzegorz
Published: November 2024

Purpose: The book amounts are treated as values of a random variable whose distribution is
a mixture of the distributions of the correct amount and the true amount contaminated by error.
The mixing coefficient is equal to the proportion of the items with non-zero errors amounts.
Below we consider a problem of testing appropriately formulated statistical hypotheses about
admissibility of the total or the mean accounting errors. Hypotheses can be verified by the
likelihood ratio test. In this paper, we show how to estimate parameters of the likelihood
function.
Design/methodology/approach: The book amounts are treated as values of a random variable
whose distribution is a mixture of the distributions of the correct amount and the true amount
contaminated by error. The mixing coefficient is equal to the proportion of the items with non-
zero errors amounts. Below we consider a problem of testing appropriately formulated
statistical hypotheses about admissibility of the total or the mean accounting errors. Hypotheses
can be verified by the likelihood ratio test. In this paper, we show how to estimate parameters
of the likelihood function.
Findings: The work presents formulas for the parameters of the likelihood function.
These parameters were obtained using the ECM algorithm.
Originality/value: The problem of estimating the average audit error is very common in
economic research. A method for estimating the average audit error based on the likelihood
function was proposed. The parameters of the likelihood function were estimated using the
ECM algorithm.
Keywords: ECM algorithm, likelihood ratio test, mixture of probability distribution.
Category of the paper: Research paper.
Cybersecurity analytics: leveraging business analytics in Industry 4.0 settings
Authors:   Silesian University of Technology, Organization and Management Department, Economics and Informatics Institute, Wolniak Radosław
Published: November 2024

Purpose: The purpose of this publication is to present the applications of usage of business
analytics in cybersecurity analytics.
Design/methodology/approach: Critical literature analysis. Analysis of international literature
from main databases and polish literature and legal acts connecting with researched topic.
Findings: The integration of business analytics into cybersecurity practices within Industry 4.0
signifies a pivotal advancement in safeguarding organizational assets against the evolving cyber
threat landscape. As industrial systems grow more complex and interconnected, traditional
security methods focused on perimeter defenses are increasingly inadequate. Modern
cybersecurity strategies must therefore incorporate advanced analytics to manage and mitigate
risks effectively. Business analytics enhances cybersecurity through sophisticated machine
learning algorithms, predictive capabilities for anticipating future threats, and improved
incident response via real-time monitoring and automated alerts. These innovations foster
a proactive and efficient security approach, enabling swift detection, response, and informed
decision-making based on thorough risk assessments. Despite these advantages, challenges
such as data overload, false positives, integration hurdles, and the need for specialized expertise
persist. Additionally, concerns about data privacy, costs, and analytical complexity must be
managed. Embracing business analytics while addressing these challenges will enable
organizations to fortify their security posture, optimize resource use, and adapt to the demands
of Industry 4.0, thereby shaping the future of cybersecurity in a rapidly evolving digital
landscape.
Originality/Value: Detailed analysis of all subjects related to the problems connected with the
usage of business analytics in the case of cybersecurity analytics.
Keywords: business analytics, Industry 4.0, digitalization, artificial intelligence, real-time
monitoring; cybersecurity.
Category of the paper: literature review.
Moving Towards Better Digital Accessibility – Current Status And Challenges
Authors:   University of Siedlce, Faculty of Social Sciences, Wójcik-Augustyniak Marzena , Szajczyk Marek ,   University of Siedlce, Faculty of Social Sciences, Cielemęcki Mariusz ,   University of Siedlce, Faculty of Social Sciences, Szarek Stanisław ,   University of Siedlce, Faculty of Social Sciences
Published: November 2024

Purpose: This article aims to identify the current challenges faced by various stakeholder
groups in increasing digital accessibility in EU countries.
Design/methodology/approach: The main assumption of this article is that in order to
enhance the level of digital accessibility, it is necessary to take not only legal actions but
also engage in social and training initiatives. The basic research problem is: What challenges
related to acquiring new competencies are currently being faced by stakeholders involved in
ensuring website accessibility. The research was based on quantitative data collection
methods.
Findings: The results of quantitative research based on 432 surveys collected among project
stakeholders in four countries: Slovenia (N = 173), Poland (N = 135) Greece (N = 89) and Spain
(N = 35) shows that IT/Web development professionals, young adults, and those with higher
education are more knowledgeable about accessibility standards and regulations. Preferences
for additional training on web accessibility varied, with uniform importance placed on
international certification. Training plans were positively correlated with occupation,
particularly among IT professionals, but showed no correlation with age, country, education
level, or employment status.
Research limitations/implications: Implications resulting from the conducted research
include both social and practical aspects. Socially, the findings highlight the need to engage
non-IT professionals and older individuals in digital accessibility training to ensure broader
inclusion. Practically, the research points to the necessity of developing comprehensive training
programs and certification standards, as well as streamlining recognition systems for digital
accessibility qualifications, to enhance overall digital competency and inclusion.
Originality/value: The value and originality of this article lie in its dual focus on the legal and
social dimensions of digital accessibility, particularly within the European Union. It provides
a comprehensive analysis of the current challenges faced by stakeholders in ensuring website accessibility, emphasizing the necessity of both regulatory measures and practical training
initiatives.
Keywords: digital accessibility, digital inclusion, digital accessibility skills, digital
accessibility professions.
Category of the paper: scientific research.
KHOI-TANBA: WORLDVIEW OF CHASING BEES AND WASP AWAY BY THE KHURKHULS OF MANIPUR
Authors: Singh Ngathem Pungfa , Singh Thiyam Rabikanta , Singh Kh. Bimol
Published: November 2024

This field work based paper is the outcome of the anthropological study conducted in the Khurkhul village of Manipur where the ‘Khoi-tanba’, is performed as a way of warding off the evils from causing death and miseries in the family. ‘Khoi-tanba’, literally meaning chasing the bees/wasp away, in Manipuri language, is an aged old magico-religious practice of the ‘Meiteis’ still performed by the ‘Khurkhuls’ in the Khurkhul village in Manipur with the help of a ‘Maiba’, a male religious leader authorised for sacred performances and also a traditional healer on the belief that the presence of a typical bee hive/s (but not of the honey bees) in someone’s homestead particularly on the Northern or the ‘Awang’ side of the house will bring inevitable death in the family. Getting rid of giant bees and wasp is a means of getting rid of psychological fears from causing havoc in the family and to relief from the apprehension of damaging their mental health conditions. The main objective of studying the cult of ‘Khoi-tanba’ is to understand their traditional ways of preventive measures towards mental health. The Khurkhuls are much concerned about their health and the concept of health among them is not just the mere absence of diseases. All that activities for seeking good health as well as the treatment of already afflicted ones requires both modern and traditional practices. It is evident that physical well-being and mental satisfaction are two sides of the same coin: one cannot live a healthy life without honouring the mental aspect. The present study adopted standard techniques of modern ethnographic research such as Observation, Case study and Interview. The primary data were collected from the traditional health practitioners or the ‘Maibas’ as well as members of the households in question. The results of the study indicated that ‘Khoi-tanba’ cannot be performed on any day but only on the specific days of the particular month known as the ‘tatnaba numit’ because it is not considered to be an auspicious occasion as per their schemas. Further, it also involves the leaves of the sacred ‘tairen’ (Toona ciliata) and hymns chanted by the ‘maiba’ to avoid miseries from multitudes of spirits in mischief.