bluuebunny/crossref_metadata_2025 huggingface dataset:
A NOVEL DIMENSIONALITY REDUCTION APPROACH TO IMPROVE MICROARRAY DATA CLASSIFICATION
Authors: Hamim Mohammed , El Mouden Ismail , Ouzir Mounir , Moutachaouik Hicham , Hain Mustapha
Published: January 2021

Cancer tumor prediction and diagnosis at an early stage has become a necessity in cancer research, as it provides an increase in the treatment success chances. Recently, DNA microarray technology became a powerful tool for cancer identification, that can analyze the expression level of a different and huge number of genes simultaneously. In microarray data, the large genes number versus a few records may affect the prediction performance. In order to handle this "curse of dimensionality” constraint of microarray dataset while improving the cancer identification performance, a dimensional reduction phase is necessary. In this paper, we proposed a framework that combines dimensional reduction methods and machine learning algorithms in order to achieve the best cancer prediction performance using different microarray datasets. In the dimensional reduction phase, a combination of feature selection and feature extraction techniques was proposed. Pearson and Ant Colony Optimization was used to select the most important genes. Principal Component Analysis and Kernel Principal Component Analysis were used to linearly and non-linearly transform the selected genes to a new reduced space. In the cancer identification phase, we proposed four algorithms C5.0, Logistic Regression, Artificial Neural Network, and Support Vector Machine. Experimental results demonstrated that the framework performs effectively and competitively compared to state-of-the-art methods.
ABSTRAK: Ramalan tumor kanser dan diagnosis pada peringkat awal telah menjadi keperluan dalam kajian kanser, kerana ia membuka peluang peningkatan kejayaan dalam rawatan. Kebelakangan ini, teknologi mikrotatasusunan DNA menjadi alat berkuasa bagi mengenal pasti kanser, di mana ia mampu menganalisa level ekspresi yang pelbagai dan gen-gen yang banyak secara serentak. Dalam data mikrotatasusunan, gen-gen yang banyak ini bakal menentukan ramalan prestasi berbanding analisa melalui rekod-rekod yang sebilangan. Fasa pengurangan dimensi adalah perlu bagi mengawal kakangan “penentuan kedimensian” dataset mikrotatasusunan, sementara itu ia memantapkan lagi keberkesanan kenal pasti kanser. Kajian ini mencadangkan rangka kombinasi kaedah pengurangan dimensi dan algoritma pembelajaran mesin bagi mencapai prestasi ramalan kanser terbaik dengan menggunakan pelbagai dataset mikrotatasusunan. Dalam fasa pengurangan dimensi, kombinasi pemilihan ciri dan teknik pengekstrakan ciri telah dicadangkan, Pengoptimuman Pearson dan Koloni Semut bagi memilih gen yang paling penting, Analisis Komponen Prinsipal dan Analisis Komponen Prinsipal Kernel, bagi menukar gen terpilih yang linear dan tak linear kepada ruang baru yang dikurangkan. Dalam menentukan fasa mengenal pasti kanser, kajian ini mencadangkan empat algoritma iaitu C5.0, Regresi Logistik, Rangkaian Neural Buatan dan Mesin Vektor Sokongan. Dapatan kajian menunjukkan rangka ini adalah berkesan dan kompetitif berbanding kaedah semasa.
ENERGY AND STRUCTURE STATES OF LOW-LYING BANDS IN 156Gd
Authors: Usmanov P.N. , Yusupov E.K.
Published: January 2021

The experimental results of the literary and electronic nuclear database for 156Gd were summarized and analyzed. Inertial parameters of rotating core were determined using the Harris method. The theoretical values of energy and wave functions were calculated within the framework of a phenomenological model that takes into account Coriolis mixing of state rotational bands. The calculated energy values were compared with existing experimental data, which were in good agreement.
ABSTRAK: Hasil dapatan kajian melalui eksperimen pangkalan data nuklear dan elektronik bagi 156Gd diringkaskan dan dianalisis. Parameter inersia putaran berputar ditentukan menggunakan kaedah Harris. Nilai teori fungsi tenaga dan gelombang dikira dalam kerangka model fenomenologi yang mengambil kira campuran Coriolis pada band putaran keadaan. Nilai pengiraan tenaga dibandingkan dengan data eksperimen memberikan persetujuan yang baik.
Building the readings scale to teach reading and writing to the student of the first grade
Authors: D. Helles Dawoud. , M. Alrantesi Mahmoud.
Published: January 2021

The study aimed at designing the readiness scale of learning to read and write for first grade students when they entered school, and to reveal the impact of the scale in the development of their abilities and the degree of readiness to learn to read and write. The sample of the study consisted of (64) male and female pupils from the first-grade students in Dar Al Arqam Islamic Model School in Gaza. The questions and its vocabulary were constructed in the light of readiness skills for learning to read and write. The scale consisted of (30) questions divided into (5) skills: (visual discrimination, auditory recall, auditory discrimination, auditory recall, auditory interpretation). It was applied to the research sample, the researchers found that there were statistically significant differences at the mean level (α = 0.05) in the average readiness to learn literacy between males and females in favor of females. The researchers recommended the need to hold training courses for teachers of kindergarten to deal with the skills necessary for reading and writing readiness.
Sertoli Leydig Cell Tumour Initially Misdiagnosed as Polycystic Ovarian Syndrome and Congenital Adrenal Hyperplasia: A Case Report
Authors: Paudyal Pooja , Gurung Geeta , Baral Josie , Kharel Nisha
Published: January 2021

Sertoli-Leydig cell tumor of the ovary is an unusual neoplasm that belongs to a group of sex cord-stromal tumors of the ovary and accounts for less than 0.5% of all primary ovarian neoplasms. They are often characterized by the presence of mass with androgen production and signs of virilization. Due to the substantially low incidence of Sertoli-Leydig cell tumors, information on clinical behavior, prognostic factors, and optimal management arelimited. Here in, we report a case of aprimary ovarian Sertoli-Leydig cell tumor in a 21-year-old student, previously diagnosed to have polycystic ovarian syndrome and subsequently congenital adrenal hyperplasia, who presented with a large abdominal mass and features of virilization along with elevated serum testosterone levels. Fertility sparing unilateral salpingo-oophorectomy was done and adjuvant chemotherapy was given after histopathology showed moderate to poorly differentiated Sertoli-Leydig cell tumor. Following surgery, her features of hyperandrogenism resolved and serum testosterone levels returned to normal.
An Unusual Case of Chronic Partial Quadriceps Tear in a Child: A Case Report
Authors: Yeak Raymond , Yap Yee Yee , Nasir M Nizlan
Published: January 2021

Quadriceps tendon rupture usually occurs in adults and is rare in children. A six-year-old boy was playing at home and had a fall. He was unable to extend his right knee but there was no gap felt over the patella tendon or quadriceps. He was first seen by a family doctor and presented late to the surgeon three months after the injury. Radiographs and ultrasound were performed. The magnetic resonance imaging confirmed the findings of partial quadriceps tear. The patient was put in a cylinder case with the knee in extension for two months. Six months post-injury, he regained full range of motion without any complications. We present an unusual case of partial quadriceps tear in an otherwise healthy six-year-old boy that was treated successfully despite a delayed presentation. Besides a high index of suspicion, magnetic resonance imaging is a good modality to detect partial quadriceps tear in children.
Prevalence of Misuse of Topical Corticosteroid among Dermatology Outpatients
Authors: Shrestha Shristi , Joshi Smita , Bhandari Sajana
Published: January 2021

Introduction: Topical corticosteroids misuse has become one of the burning issues in many countries across the globe. They are known to cause a myriad of adverse effects which include local effects commonly and systemic effects rarely. In dermatology practice, one of the common problems we see these days are steroid-induced and steroid aggravated dermatoses. So, this study was done to find the prevalence of misuse of topical corticosteroid among dermatology outpatients.

Methods: A descriptive cross-sectional study was done in the outpatient department of dermatology at atertiary care hospital for 18 months. Ethical clearance was obtained from the Institutional Review Committee of NMCTH (Reference no. 029-076/077). Convenient sampling was done. Statistical Package for the Social Sciences (SPSS) version 16 was used to tabulate the data and analyze the results. Point estimate at 95% Confidence Interval was calculated along with frequency and proportion for binary data.

Results: Out of 19464 patients, 614 (3.15%) (2.91%-3.39% at 95% Confidence Interval) gave a history of applying steroid containing creams. Among them, 220 (35.8%) belonged to the age group 21-30 years. Dermatophytoses were the skin disease where TCS was most commonly misused followed by melasma in 425 (69.2%) and 115 (18.7%) respectively. Beclomethasone was the steroid preparation that was misused in the maximum number of patients in 271 (44.1%). Some form of adverse effects was seen in 554 (88.6%) patients.

Conclusions: Non-prescription sale of topical corticosteroids is the major cause of topical corticosteroids abuse in Nepal. Creating awareness among the prescribers as well as the patients is the current need.
Professional Quality of Life among Medical Doctors Working in Kathmandu: A Descriptive Cross-sectional Study
Authors: Vaidya Anju , Karki Shristi , Dhimal Meghnath , Gyanwali Pradip , Baral Dibash , Pandey Ashok , Jha Anjani Kumar
Published: January 2021

Introduction: The practice of medicine is an honorable profession besides being accompanied by a demanding environment. This study aimed to find out the professional quality of life of medical doctors working in Kathmandu valley.

Methods: A descriptive cross-sectional study was conducted among 174 Nepalese medical doctors working in different hospitals of Kathmandu valley. Ethical approval was taken from the Ethical Review Board of the Nepal Health Research Council (Reference Number: 830). The data collection tool used in the study was WHO Professional Quality of Life Scale-5 to collect data about Compassion satisfaction, Burnout and Secondary traumatic stress among medical doctors working in Kathmandu valley. Data analysis was done in the Statistical Package for the Social Sciences version 16.0.

Results: Out of 174 participants, 101 (58%), 126 (72.4%) and 135 (77.6%) were found to have moderate level of Compassion satisfaction, Burnout and Secondary Traumatic Stress respectively.

Conclusions: More than half, nearly two-third, and more than two-third participants had moderate levels of Compassion satisfaction, Burnout and Secondary Traumatic Stress respectively. The overall study findings reflected good balance between Compassion satisfaction and Compassion fatigue (burnout and secondary traumatic stress) among the Nepalese medical doctors. Further assessment of professional quality of life of doctors as well as other health care workers via Multifaceted and large-scale study is recommended.
Vitamin D Deficiency among Patients Visiting a Tertiary Care Hospital: A Descriptive Cross-sectional Study
Authors: Poudel Nimesh , Dhakal Subodh Sagar , Sukhupayo Renu , Karki Dambar Bahadur
Published: January 2021

Introduction: Vitamin D deficiency is a common condition prevalent among both developed and developing countries where it is seen mostly in females. It has been linked to various skeletal and non-skeletal diseases. This study was done to find out the prevalence of Vitamin D deficiency and clinical features of deficient patients attending the outpatient department of a tertiary care hospital.

Methods: This descriptive cross-sectional study was done among the patients attending the outpatient department of a tertiary care hospital in Kathmandu, Nepal. The study was conducted from May 2019 to July 2019. The ethical approval was taken from the Institutional Review Committee (ref no. 310520113). Convenient sampling was done. The collected data was entered in Microsoft Excel and was analyzed in the Statistical Package for the Social Sciences (SPSS) version 26.

Results: Out of 481 participants, the prevalence of vitamin D deficiency was 335 (69.6%). Severe vitamin D deficiency was seen in 78 (16.2%) and insufficient vitamin D in 77 (16%) of the patients. The mean serum vitamin D concentration by gender was 22.38±17.07 ng/ml in males and 18.89±15.25 ng/ml in females. A total of 263 (54.6%) females and 72 (14.97%) males had vitamin D deficiency. The most common symptoms found in vitamin D deficiency patients were fatigue 187(55.8%), muscle cramps 131(39.1%), generalized myalgia 125(37.31%), bone and joint pain 111(33.13%)

Conclusions: Vitamin D deficiency was prevalent especially in females and elderly people. Fatigability was present in more than half of the vitamin D deficient patients.
Prevalence of Type II Diabetes Mellitus Among Adult Population in Medical Department of A Tertiary Care Centre
Authors: Karki Lochan , Rana Krishna , Shahi Manisha , Pradhan Anjila , Thapa Roshina , Yogi Prajwala , Niroula Aliska
Published: January 2021

Introduction: Diabetes mellitus is a chronic metabolic disease that is mainly associated with a number of lifestyle behaviors. There is a high discrepancy among urban and rural populations with the prevalence of diabetes in rural areas as 2.5% and a high prevalence of 14.6% in urban areas. Type 2 diabetes mellitus accounts for the majority of all diabetes cases with a number of chronic effects that include cardiovascular disease, kidney disease, blindness, and disability. This study is done to determine the prevalence of Type II Diabetes Mellitus among the adult population in the medical department of a tertiary care center.

Methods: A descriptive cross-sectional study was done in a medical department of a tertiary care center of Himal Hospital Private Limited from March to April 2020. Ethical approval was taken from the Ethical Review Board of NHRC (Reference Number 752). All the data of the last two years from the medical record section were included in the study. The convenience sampling technique was followed. Descriptive statistical analysis was done.

Results: The study showed the prevalence of Type II Diabetes Mellitus among the adult population to be 23.93 % (0.23) (C.I= 0.20-0.26). Prevalence was found to be ...

Conclusions: The prevalence of Type II Diabetes Mellitus was found to be higher than the previous study done in similar settings.
Conducting Qualitative Interviews using Virtual Communication Tools amid COVID-19 Pandemic: A Learning Opportunity for Future Research
Authors: Sah Lalita , Singh Devendra Raj , Sah Rajeeb Kumar
Published: January 2021

The COVID-19 pandemic has threatened the health and wellbeing of the global citizens which has led to a significant change in attitude, lifestyle, and behavior of people from diverse professions, including academics and researchers. Doctoral students and funded researchers with the time limit to their research project have experienced stress and anxiety due to the struggle of negotiating and managing the timeline to complete the fieldwork for their research. In the current circumstances, an increasing number of researchers are looking for alternative methods to conduct the fieldwork and complete the data collection. In this context, the aim of this viewpoint is to provide reflections on the challenges and opportunities experienced by the authors while conducting qualitative research fieldwork during the COVID-19 pandemic.
Study on Clinico-Demographic Characteristics of Orthopaedic Cases in a Tertiary Care Centre: A Descriptive Cross-sectional Study
Authors: Rijal Badri , Rana Krishna , KC Srijana , Lamsal Jamuna
Published: January 2021

Introduction: Orthopedic conditions include a range of condition varying from traumatic injuries, congenital anomalies, chronic back-pain, arthritis, rheumatologic conditions, and other. In Nepal, approximately 2.35 million people are living with musculoskeletal conditions in which 175,000 people are suffering with MSD from non-traumatic causes. The aim of the study is to observe the clinical and demographic pattern of orthopedic problems presenting in the hospital.

Methods: A descriptive cross-sectional study was done in All Nepal Hospital Private Limited in the month of November. The data from the medical record section was retrospectively collected. Sample size of 384 was included and convenience sampling technique was used. The descriptive statistical analysis was done.

Results: Eight hundred forty four cases were included in the study. Implant removal was the main condition for admission in the hospital 105 (12.44%) followed by Forearm Bone Fracture 84 (9.95%) and Cut Injury 64 (7.58%). Most cases presented during the time 6 PM to 12 AM 312 (36.96%).

Conclusions: Most of the orthopedic cases presented in the evening and night time. Implant removal, forearm bone fracture and cut injury form the major bulk of the cases.
Anatomical Variations in Circle of Willis in Patients Undergoing CT Cerebral Angiography in a Tertiary Hospital in Nepal: A Descriptive Cross-sectional Study
Authors: Dhakal Prajwal , Kayastha Prakash , Paudel Sharma , Suwal Sundar , Sharma Mohan Raj , Ghimire Ram Kumar
Published: January 2021

Introduction: Variation in Circle of Willis is a commonly encountered entity in patients undergoing computed tomography angiography, identification of which is crucial in the management of patients with vascular pathologies. The aim of the study was to find out the anatomical variations in the Circle of Willis in patients undergoing Computed Tomography cerebral angiography in a tertiary hospital in Nepal.

Methods: This is a descriptive cross-sectional study involving 95 patients using convenient sampling techniques who were sent to the Department of Radiology and Imaging, Tribhuvan University Teaching hospital, for further evaluation of suspected vascular pathologies in the brain from April 2017 to September 2017. Ethical approval was taken from the Institutional Review Committee of the Institute of Medicine with reference number 326 (6-11-E). CT angiographic images of these patients were evaluated for the presence of variations in Circle of Willis, aneurysms, and other vascular pathologies. Data were analyzed using SPSS.

Results: Among 95 subjects included in the study, the anatomical variations in the arteries of Circle of Willis was seen in 52 (54.7%) patients, hypoplastic posterior communicating artery being the most common variation 33 (34.7%). The aneurysm was seen in 22 (23.2%) of cases.

Conclusions: CT Angiography is a commonly performed imaging modality for suspected cases of cerebral aneurysms and various other vascular pathologies. Multidetector computed tomography can effectively detect variations in arteries of Circle of Willis, recognition of which is crucial in operative management of vascular pathologies.
A kutatási adatok dokumentálását elősegítő szoftverek
Authors: Holl András
Published: January 2021

A nyílt tudomány (Open Science, OS) a kutatási folyamat minden összetevőjét hozzáférhetőbbé, láthatóbbá kívánja tenni. A kutatók vállára ezzel újabb terhek kerülhetnek – mind a költségek, mind a feladatok szempontjából. A nyílt tudomány gyakorlata csak akkor terjedhet el, ha ezeket a terheket csökkenteni tudjuk. A nyílt hozzáférésű tudomány kívánalmainak egyike a megfelelő dokumentálás, ami jelentős részben metaadatok alkalmazását jelenti. Mind a metaadatok létrehozását, mind a kutatási objektumok egyedi azonosítókkal való ellátását megkönnyíti, ha a kutatás során ezeket a feladatokat támogató szoftvereket alkalmaznak. Előadásunkban az ilyen, OS-támogató vagy OS-barát szoftverek kérdését járjuk körül, a kutatási adatoktól egészen a tudományos publikációkig.
Az informatikai gondolkodással kapcsolatos vélekedések az Eszterházy Károly Egyetem osztatlan informatikatanár szakos hallgatói körében
Authors: Csernai Zoltán
Published: January 2021

The idea of Computational Thinking (CT) functions as an umbrella term impacting the STEM (Science, Technology, Engineering, Mathematics) areas. The concept entails algorithmic thinking, problem solving, programming instruction, and the application of simulation games. My three phase inquiry utilises a combined research paradigm facilitates research, development, and innovation. In an earlier stage of my research I relied on a deductive approach to explore the representations of this concept in the international arena. I analysed the manifestations of Computational Thinking in the DigComp 2.1 framework system accepted by the European Union according to set criteria and investigated the capability of Computational Thinking to facilitate a methodological shift in the education profession by the application of modern digital solutions via the Complex Basic Program. In the second and current stage of my research I turn to the combined paradigm method (Sántha, 2014) to perform an empirical examination focusing on Computational Thinking-related opinions of students enrolled in undivided Informatics teacher training programs at the Eszterházy Károly University. This attitude survey utilizes a self-developed questionnaire along with interviews. The survey aims to obtain a comprehensive evaluation of prospective teachers’ views on the given theme. Based upon the respective results, in the next stage of my research I will introduce various tools and programs facilitating the development of algorithmic thinking.
Digitális ökoszisztéma a könyvtár katalógusból? Egy texas-i könyvtári kísérlet és tanulságai
Authors: Sennyey Pongrácz , Kokas Károly
Published: January 2021

SORIN (Search Organize Research and Interact) is a cloud based research workflowplatform that uses APIs to leverage the Alma-Primo catalog system to a custom madeuser interface. SORIN allows researchers to build collections, annotate items, attachedfiles, and export their contents into Google Drive (see https://library.stedwards.edu/). Developed at the Saint Edward’s University library, SORIN has been in use for thepast three years. It is built on Phoenix and, through Rest APIs its central PostgreSQLdatabase is linked to an optional React front end. In its current version, it uses Googlefor authentication and Amazon S3 for file storage. SORIN has been in use at the SaintEdward’s University library as the default catalog user interface (see: https://library.stedwards.edu/) and it provides a concrete example of how a modern LSP (LanguageServer Protocol) can be extended into library services beyond search.
Egy adatbázis születése – A saját fejlesztésű „A magyarországi szakszótárak és -lexikonok bibliográfiája” adatbázis bemutatása
Authors: Arató Balázs
Published: January 2021

The article introduces the birth and the operation of a unique Hungarian database, which contains specialist dictionaries and lexicons of several scientific areas. It describes how it can be used from user- and administrator point of view. I also tried to position it in a historical background as well. The purpose of the collection was to take stock of all works (monolingual, bilingual,multilingual) which list the vocabulary of a particular field and which (were): - published in Hungary; - not published in Hungary, but has a Hungarian author; and - Works called dictionaries are also the subject of collection, e.g. manuals with adictionary-like appendix. - One of the languages must be Hungarian.
Az EISZ open access szerződéseinek gyakorlati tapasztalatai
Authors: Sütő Péter
Published: January 2021

In the last 3 years, Electronic Information Service National Programme (EISZ) concluded transformative agreements with the leading Hungarian and international scholarly publishers which enable corresponding authors affiliated at the consortium member institutions to publish journal articles under an open access license. Terms and conditions provided by these transformative agreements require the implementation of new workflows for the publishers as well as for the librarians and the researchers. The lecture introduces the opportunities provided by these new generation agreements, and presents its success and benefits for the Hungarian research community. It describes the conditions of open access publishing in this framework and focuses on the efficiency of various methods of identification and authorisation used by the publishers.
La noticia sobre ciencia
Authors: Mangione Antonio
Published: January 2021

La complejidad de la actividad científica no queda reflejada a través de la noticia. Se propone aquí que aspectos vinculados a los procesos de investigación científica están escasamente desarrollados en las noticias sobre ciencia. Por el contrario,
aspectos vinculados a los resultados de la investigación científica están altamente representados. Se analizaron 35 noticias del portal Clarín (Argentina), formato digital entre los días 01-01-2016 al 1-07-2017, mediante metodología de semana construida. Como dimensiones vinculadas a procesos se consideraron: abordaje epistemológico, ético, político e histórico. Como dimensiones vinculadas a resultados: optimismo epistemológico, utilidad, progreso y espectacularidad. Se analizó también si las notas estaban firmadas por su autor. El 82% de las noticias tienen sesgo hacia resultados y de ellas 83%
son de agencias o redacción (no firmadas). El 85% de las notas basadas en procesos están redactadas por otros medios o firmadas. Se analizaron también notas de opinión (n=27). El 44% presenta un sesgo a favor de procesos. Proponemos que
la incorporación en las noticias de dimensiones vinculadas a procesos de la investigación científica favorece el diálogo, la discusión y el debate entre expertos científicos y públicos. El perfil de las noticias firmadas refuerza la idea que una mejor comunicación de la ciencia en medios es posible.
A Study on Behavioural Analysis of Specific Ransomware and its Comparison with DBSCAN-MP
Authors: Vinodhini V. , Kumuthini C. , Santhi K.
Published: January 2021

Ransomware attack is known to as WCRY or WannaCry. This ransomware is intriguing advantage of a recently disclosed Microsoft vulnerability (“MS17-010 – “Eternalblue” ) coupled with the Shadow Brokers tools release. After a computer is fouled, WannaCry ransomware targets and encrypts 176 file types. Some of the file types WannaCry targets are database related files, multimedia and archive related files, as well as Microsoft Office documents. In its ransom note, which supports 27 languages, it initially demands US$300 worth of Bitcoins from its fatalities—an amount that increases incrementally after a definite time limit. The victim is also given seven days before the pretentious files are deleted.

The WannaCry Ransomware consists of multiple components. It arrives on the ruined computer in the form of a dropper, a self-reliant program that extracts the other application mechanism embedded within it. Those components include: 

An application that encrypts and decrypts data
Files containing encryption keys
A copy of Tor 
The program secret code is not obfuscated and was relatively easy for security pros to analyze. Once it is launched, WannaCry tries to access a hard-coded URL (the so-called kill switch); if it can't, it proceeds to investigate for and encrypt files in a slew of important formats, ranging from Microsoft Office files to MP3s and MKVs, leaving them completely inaccessible to the user. It then displays a ransom notice, demanding numbers in Bitcoin to decrypt the files.
ДРАЙВЕРИ ЦИФРОВОЇ ТРАНСФОРМАЦІЇ ОРГАНІВ ПУБЛІЧНОЇ ВЛАДИ
Authors: Логвінов Валерій , Малонога Світлана
Published: January 2021

Розглянуто елементи цифрової трансформації в органах публічної влади, досліджено фактори впливу на її успіх та залежність від них, а саме – цифрових технологій, цифрового лідерства та цифрової культури. Розкривається суть цих понять та їх трактування різними авторами. Запропонована трирівнева концептуальна модель трансформації уряду, яка розглядає трансформаційний уряд (t–Уряд) як сукупність окремих елементів, що забезпечують соціальні, організаційні та техніко–технологічні напрямки діяльності органів публічної влади. На першому рівні моделі знаходяться базові складові, на яких їх побудована діяльність. Це моделі і рамки, архітектура уряду, протоколи та стандарти. Другий рівень включає в себе чотири елементи, які відображають основні аспекти, що забезпечують діяльність органів публічної влади і являються її суттю: стратегію розвитку, адміністративно–управлінські процеси (АУП), інформаційні ресурси та цифрові технології. Третій рівень – управління змінами та структура (t–Уряду), виокремлено фактори, що впливають на дану структуру та діяльність органів публічної влади. Застосування даної моделі дасть можливість представити загальну структуру t–Уряду, у тому числі органів публічної влади усіх рівнів. Доведена доцільність постійного реагування на означені фактори впливу, які запропоновано розглядати згідно з чотирма вимірами: причинами цифрової трансформації; об’єктами цифрової трансформації; процесами та результатами трансформації. Встановлено, що в основі трансформаційних перетворень, орієнтованих на вирішення існуючих проблем в управлінні лежать три складові – практика, дослідження і розвиток, поєднання яких є запорукою успішної цифрової трансформації органів публічної влади.
НОРМАТИВНО-ПРАВОВІ ЗАСАДИ ІНФОРМАЦІЙНОЇ ВІДКРИТОСТІ ТА КОМУНІКАЦІЙНОЇ ВЗАЄМОДІЇ ОРГАНІВ ПУБЛІЧНОЇ ВЛАДИ З ГРОМАДСЬКІСТЮ
Authors: Приліпко Сергій
Published: January 2021

Сучасна концепція публічного управління вимагає від посадових осіб органів публічної влади бути більш чутливими до запитів громадян, ширше залучати інститути громадянського суспільства до прийняття державно-управлінських рішень, здійснювати свою діяльність прозоро та відкрито. Інформування громадськості та комунікаційна взаємодія є основними інструментами  забезпечення відкритості і прозорості діяльності суб’єктів владних відносин. Влада повинна бути зацікавленою у налагодженні  комунікаційного зв’язку у різних формах , що сприятиме успішності реалізації задекларованих реформ та підвищення довіри громадян.Встановлено, що інформаційні відносини між суб’єктами публічного управління базуються на принципах відкритості,  проступності, достовірності, повноти, правомірності одержання, використання та поширення інформації. В той же час для налагодження двостороннього зв’язку комунікаційна взаємодія у публічному управлінні між представниками влади та громадськості повинна відповідати принципам прозорості, відкритості, чесності, оперативності, адекватності, партнерства, достовірності та підзвітності. В умовах розвитку демократичного суспільства кожен громадянин має право на отримання повноцінної та достовірноїінформації про діяльність органів публічної влади, а останні зобов’язані вчасно й у повній мірі її висвітлювати, ширше залучати громадськість до формування та реалізації державної політики. На основі аналізу нормативно-правового забезпечення визначено, що інформаційно-комунікаційна діяльність регулюється окремими положеннями Конституції України, законів України, постанов Кабінету Міністрів  України та інших нормативно-правових актів. Вони розкривають права та обов’язки органів публічної влади прозоро висвітлювати інформацію та звітуватися про свою діяльність, надавати відповіді на запити, публічно обговорювати проєкти нормативно-правових актів, проводити громадські слухання та враховувати думку громадськості. Встановлено, що кращими формами для комунікаційної взаємодії є: прийом громадян, зустрічі, консультації, круглі столи, семінари, конференції, засідання, зібрання, наради, збори, урочисті події, громадські слухання, публічні дебати, демонстрації, презентації, виставки, брифінги, прес-конференції, прес-тури, вхідна та вихідна кореспонденція, повідомлення у ЗМІ, соціальних мережах та на веб-сайтах. Зазначено, що залучення програм та проєктів міжнародної технічної допомоги сприяє налагодженню комунікаційної взаємодії між органами публічної влади та представниками інститутів громадянського суспільства, зокрема під час розроблення комунікаційної стратегії.
Mukopolisakkaridoz Hastalarının Geriye Yönelik Olarak Değerlendirilmesi: Tek Merkez Deneyimi
Authors: BİLGİN Hüseyin , ERDÖL Şahin
Published: January 2021

Bu çalışmada mukopolisakkaridoz tanısı ile izlediğimiz hastaların klinik, demografik ve laboratuvar verilerinin değerlendirilmesi amaçlanmıştır. Bursa Uludağ Üniversitesi Tıp Fakültesi Çocuk Metabolizma Hastalıkları Bilim Dalında mukopolisakkaridoz (MPS) tanısı ile izledi-ğimiz 41 hasta geriye yönelik olarak değerlendirilmiştir. Hastalarımızın dosyalarından MPS tipleri, tanı yaşları, güncel yaşları, cinsiyetleri, doğum ağırlığı, doğum şekli, büyüme ölçütleri, anne-baba arasındaki akrabalık düzeyi ve kardeş ölüm öyküsü kaydedilmiştir. Hastaların yaş ortalaması 9,41 ± 5,79 yıl (dağılım, 0,91-23 yıl) olarak saptanmıştır. Tanı alma yaşları 4,64 ± 4,01 yıl (dağılım, 0,50-19 yıl) olarak izlenmiştir. Hastaların 12’si (% 29,3) MPS tip 4a, 10’u (% 24,4) MPS tip 3, 7’si (% 17) MPS tip 6, 5’i (% 12,2) MPS tip 1, 5’i (% 12,2) MPS tip 2 ve 2’si (% 4,9) MPS tip 7 tanısı ile izlenmektedir. 22 (% 53,6) hastada akrabalık öyküsü, 4 hastada (% 9,7) de ise kardeş ölüm öyküsü mevcut idi. Hastaların 24’ünde (% 58,5) kardiyak tutulum, 19’unda (% 46,3) korneal bulanıklık saptanmıştır. Ayrıca 33 (% 80,5) hastada ‘dizostozis multipleks’ tespit edilmiştir. Sonuç olarak, çalışmamızda MPS tip 4a en sık izlenen tiptir. MPS tip 4a’nın en önemli fizik muayene bulgusu büyüme geriliği, kaba yüz görünümü ve iskelet deformiteleridir. Görüntülemede en önemli bulgu ‘dizostozis multiplekstir’. Hastalarımızdaki en sık kardiyak tutulum ise mitral yetmezlik olarak saptanmıştır.
PERBEDAAN NILAI SKELETAL DALAM ARAH VERTIKAL ANTARA POLA PERNAFASAN NORMAL DAN PERNAFASAN MELALUI MULUT PADA PASIEN DI KLINIK ORTODONTI RSGMP FKG USU TAHUN 2009-2013
Authors: Hilda Fitria LuBis  , Aida Violiny
Published: January 2021

Pola pernafasan mealui mulut sering dikaitkan dengan pertumbuhan dan perkembangan dentokraniofasial. Perubahan pola pernafasan melalui hidung ke mulut telah dipercaya sebagai salah satur faktor etiologi yang menyebabkan pertumbuhan vertikal wajah yang ekstrim. Tujuan dari penelitian ini adalah untuk melihat perbedaan nilai skeletal dalam arah vertikal antara pola pernafasan normal dan pernafasan melalui mulut pada pasien di klinik ortodonti RSGMP FKG USU tahun 2009-2013. Penelitian ini terdiri dari 44 radiografi sefalometri dari pasien yang berumur 8-12 tahun dengan maloklusi. Selanjutnya, sudut MP-SN dan NSGn pada masing-masing kelompok diukur dan data diolah dan dianalisa menggunakan uji-t independen. Hasil yang didapatkan menunjukkan bahwa kelompok dengan pola pernafasan melalui mulut memiliki sudut MP-SN (p<0,05) dan NSGn (p<0,05) yang lebih tinggi dan berbeda secara signifikan dibandingkan dengan kelopmpok dengan pola pernafasan normal. Sebagai kesimpulan, kelompok dengan pola pernafasan melalui mulut memiliki kecenderungan untuk memiliki mandibula yang berotasi searah jarum jam dan memiliki pola pertumbuhan wajah vertikal.
PENGARUH KUAH MASAM KEUENG TERHADAP KEKASARAN PERMUKAAN BASIS GIGI TIRUAN RESIN AKRILIK HEAT CURED
Authors: Sofya Pocut Aya , Ningsih Diana Setya , Octaviani Yuni
Published: January 2021

Masyarakat Aceh pada umumnya sering mengonsumsi makanan khas yang bersifat asam seperti kuah masam keueng. Makanan tersebut dapat mempengaruhi keadaan seluruh material yang terpapar olehnya seperti gigi tiruan resin akrilik heat cured. Bahan ini mampu menyerap kuah masam keueng sehingga menyebabkan perubahan kekasaran permukaan resin akrilik heat cured. Tujuan penelitian ini adalah untuk mengetahui pengaruh perendaman kuah masam keueng terhadap kekasaran permukaan basis gigi tiruan. Penelitian ini adalah penelitian eksperimental laboratoriks mengunakan analisis16 spesimen resin akrilik heat cured berbentuk persegi panjang (65x10x3mm). Spesimen direndam selama 24 jam di dalam akuades, kemudian diukur kekasaran permukaan awal (Ra1) menggunakan surface roughness tester. Setelah pengukuran awal, spesimen direndam dalam kuah masam keueng selama 2 hari kemudian spesimen dicuci dan diukur kembali kekasaran permukaannya (Ra2). Hasil yang diperoleh dianalisis dengan menggunakan uji t berpasangan (p<0,05). Hasil analisis menunjukkan ada perbedaan yang bermakna kekasaran permukaaan sebelum dan sesudah terpapar kuah masam keung. Kesimpulan dari penelitian ini adalah kuah masam keueng dapat menyebabkan peningkatan kekasaran permukaan resin akrilik heat cured.
LOGAM PADUAN MAGNESIUM SEBAGAI IMPLAN BIODEGRADASI
Authors: Jakfar Subhaini
Published: January 2021

Magnesium berpotensi digunakan sebagai bahan implan sementara dikarenakan memiliki sifat biodegradasi. Makalah ini membahas tentang logam paduan sebagai implan yang terbiodegradasi. Sifat biodegradasi ini, lebih lanjut dapat dimanfaatkan untuk diaplikasikan sebagai bahan implan permanen yaitu dapat meniadakan pembedahan tahap lanjutan untuk mengeluarkan bahan implan dari bagian tubuh setelah fungsi jaringan tubuh yang digantikannya pulih. Selama berada di dalam tubuh, magnesium mengalami degradasi dan kelarutannya ini dapat diekskresikan ke luar tubuh melalui metabolisme tanpa membahayakan tubuh (biodegradasi). Akan tetapi, meskipun memiliki sifat biodegradasi dan bioresorbable, kecepatan korosi dari logam ini menjadi permasalahan sehingga menurunkan fungsi implan sendiri yaitu mengalami degradasi sebelum jaringan tubuh yang digantikan berfungsi sempurna. Kesimpulannya, penyempurnaan untuk mengurangi kecepatan korosi telah dilaksanakan untuk memperoleh kesesuaian antara kecepatan korosi magnesium dan pengembalian fungsi tulang. Beberapa perlakuan tersebut untuk mendapatkan degradasi yang sesuai dan pembentukan tulang diantaranya melalui perlakuan mekanik, pelapisan, pengaturan komposisi paduan, serta pertimbangan sifat toksisitas dengan jaringan sekitarnya.
SNP G-1082A IL-10 GENE: ALLELE AND GENOTYPE DISTRIBUTION OF PERIODONTITIS PATIENT IN YOGYAKARTA
Authors: Sari Rezmelia , Prayitno Prayitno , Fadhilah Alya Nur
Published: January 2021

Periodontitis is multifactorial inflamation process and related to disproportion of cytokine. IL-10 is a dominant noninflammatory cytokines that related to gene polymorphism. Polymorphism G-1082A IL-10 genes has been reported to increase the risk of periodontitis occurs in Italian populations, apart from different result found in Brazilian. The purpose of this research was to determine the polymorphism G-1082A IL-10 in periodontitis patients in Indonesia, especially among Yogyakarta’s Javanese. This is a case-control research with subjects according to the inclusion criteria. DNA was taken by cotton swab from the epithelial cells of buccal mucosa, and was isolated using a PrestoTM (GeneAid) kit. Genotyping analysis by using the PCR RFLP technique and descriptive results were presented. The result showed that A allele frequency is 100% and no G allele was found. AA genotype in case group has lower frequency than in control group and vice versa. From this research, it was concluded that A allele was dominant in Yogyakarta’s Javanese, and AA genotype frequency is lower in individual with periodontitis.
DIFFERENCE OF pH AND CALCIUM LEVEL OF SALIVARYIN CARIES AND CARIES FREE STUDENTS OF FAKULTAS KEDOKTERAN GIGI UNIVERSITAS SUMATERA UTARA
Authors: R Lisna Unita , Nisak Rahayu
Published: January 2021

Dental caries is a disease of hard tooth tissue in enamel, dentin and cementum, caused by bacterial activity that ferments carbohydrates leading to the dissolution of enamel due to acid produced by bacteria. Saliva contains protein, antibacterial, fluoride, calcium and phosphate ions that can protect teeth from caries. Balanced diet and adequate salivary flow will preserve to protect and maintain the health of hard tooth tissue. The caries process begins with Streptococcus mutants fermenting carbohydrates to form acids that produced a low pH of oral cavity. Low concentrated calcium in saliva can increase caries risk. The purpose of this study was to determine the volume, pH and saliva’s calcium level in caries and caries-free (control group) students of Fakultas Kedokteran Gigi Universitas Sumatera Utara. The research was an observational analytic study with cross-sectional design. The saliva studied was stimulated whole saliva taken from 46 subjects, 23 were caries and 23 were caries-free. Subjects were instructed to chew paraffin wax for 5 minutes and spitting the saliva into the pot. The examination to determine salivary volume was conducted in Laboratories of Oral Biology and Fakultas Farmasi Universitas Sumatera Utara. The result of this study showed the mean value of  salivary volume in caries group is  3.55 ± 0.633 ml/5minutes and caries-free is 6.94 ± 1.482 ml/5 minutes, caries saliva pH 5.26 ± 0.219 and caries-free 6.68 ± 0.362, and calcium saliva caries 0.98 ± 0.310 mmol/L and caries-free 1.55 ± 0.312 mmol/L. There was a significant difference (p < 0.05) between the caries group and caries-free in volume, pH and salivary calcium levels. The conclusion of this research is the caries group has lower volume, pH and calcium level of saliva than non caries group.
Far beyond the hook: Science and football in the sports coverage of Pará
Authors: Sousa André Laurent Souza Lopes , Santos Ana Lucia Prado Reis dos , Dendasck Carla Viana , Oliveira Euzébio de , Bahia Mirleide Chaar
Published: January 2021

Reports relating science and football are not frequent in the sports coverage of Pará. Understanding the causes of this problem is the main objective of this study. From the literature review of sports science in soccer, the interdisciplinarity that for decades contributes to relevant studies that resulted not only in the understanding of problems of the sport, but also in the increase in the performance of soccer players and teams. In a second moment, the work brings the dialogue between scientific culture (VOGT, 2003) and journalism, from the perspectives of scientific (BUENO, 2009) and sports journalism (BUENO, 2005; MALULY, 2005), in order to highlight the provocation of Messa (2005), which credits sports journalism of a scientific character, sports-scientific journalism, the possibility of going beyond entertainment for fans-spectators. However, it is necessary to understand, from semi-structured interviews, the limiting factors of sports coverage in Pará and the reasons for science to have little space. One possibility to expand the content involving science and football is the expertise and relationship between journalists and members of the technical committees of the football teams of Pará.
THE IMPLEMENTATION OF COVID-19 POLICY RELATED TO FINANCIAL MANAGEMENT IN THE PERSPECTIVE OF ACADEMICS AND PRACTITIONERS AT THE UNIVERSITY OF NUSA CENDANA
Authors: Mutia Karmila Dwi Lestari , Muga Maria Prudence Leda
Published: January 2021

This research aims to understand the implementation of the COVID-19 policies related to financial management in the perspective of academics and practitioners at the University of Nusa Cendana. This research uses qualitative methods and the primary data has been obtained by interviews and literature reviews regarding the Covid-19 management policy at the University of Nusa Cendana. This research focuses on the implementation of the Covid-19 financial management policy, the evaluation, and the factors that affect the Covid-19 Policy Implementation process. Research showed that from an academic perspective, the implementation of the Covid-19 policy related to financial management has not been going well because there is no socialization to academics. On the other hand, from the perspective of practitioners at Nusa Cendana University, it has been running. However, certain points must be considered such as unexpected shopping that is not yet available in the current DPA budget, Relocation and cash management when unexpected spending is insufficient, Evaluation of Covid-19 policies related to financial management at Nusa Cendana University has not been implemented properly due to the absence of a financial management policy related to Covid-19 and a system Supporting evaluations with working from home and therefore it is necessary to have a financial management policy and establish a risk management unit to anticipate if this pandemic continues.
Melatonin as an alternative to anti-flu vaccine in pregnant women
Authors: Tesarik Jan
Published: January 2021

This paper summarizes arguments in favor of replacing

anti-influenza vaccines with melatonin in pregnant women, especially those in

the first trimester of pregnancy.
Efficacy of melatonin in non-intensive care unit patients with COVID-19 pneumonia and sleep dysregulation
Authors: Brusco Luis I. , Cruz Pablo , Cangas Alicia V , Rojas Carmen González , Vigo Daniel E , Cardinali Daniel Pedro
Published: January 2021

The association of sleep disruption with a higher vulnerability to

COVID-19 infection is a subject of major clinical importance. In patients with

pneumonia associated with COVID-19 admitted to non-intensive care unit (NICU) several

factors, like the disrupting influence of respiratory distress, medication, greater

stress due to social isolation, and lack of appropriate exposure to environmental

light can be instrumental to disrupt sleep/wake cycle. The

therapeutic potential of melatonin to counteract the consequences of COVID-19

infection has been advocated. Because of its wide-ranging effects as an

antioxidant, anti-inflammatory, and immunomodulatory compound, melatonin could

be unique in impairing the consequences of SARS-CoV-2 infection. Melatonin is

also an effective chronobiotic agent to reverse the circadian disruption of social

isolation and to control delirium in severely affected patients. Properly

administered, melatonin may restore the optimal circadian pattern of the

sleep-wake cycle and improve clinical condition in pneumonia associated with COVID-19

patients. The present review article discusses the importance of maintaining

normal sleep and circadian rhythmicity in NICU patients and provides

preliminary data suggesting the efficacy of melatonin (9 mg/day) to reduce

length of stay of pneumonia patients associated with COVID-19 in NICU.