bluuebunny/crossref_metadata_2025 huggingface dataset:
Prosodic focus marking in Seoul Korean-speaking children: the use of prosodic phrasing
Authors: Yang Anqi , Cho Taehong , Kim Sahyang , Chen Aoju
Published: July 2024

Introduction

Prosodic focus marking in Seoul Korean is known to be achieved primarily through prosodic phrasing, different from the use of prosody for this purpose in many other languages. This study investigates how children use prosodic phrasing for focus-marking purposes in Seoul Korean, compared to adults.

Methods

Using a picture-matching game, we elicited semi-spontaneous production of SOV sentences in various focus conditions from monolingual Seoul Korean-speaking children aged 4 to 11 years.

Results

We found that the children varied prosodic boundaries to distinguish narrow focus from pre-focus and broad focus in a largely adult-like manner at the age of 4 to 5; at this age, they did not distinguish narrow focus from post-focus or contrastive focus using prosodic boundaries, similar to the adults. Their use of the prosodic boundaries in distinguishing the focus conditions was not fully adult-like in terms of frequency until the age of 10 to 11.

Discussion

In conjunction with the findings of previous studies on the acquisition of focus marking in Germanic languages, performed using a similar experimental method, our findings suggest that Seoul Korean-speaking children acquire the use of prosodic phrasing earlier than Dutch-speaking children acquiring the use of pitch accent but slightly later than Stockholm Swedish-speaking children acquiring the use of a prominence-marking high tone. These findings imply that the rate of focus-marking acquisition depends on the transparency of the form-meaning mapping between the phonological cue and focus.
Research on sleep disorders and related risk factors among healthcare workers from Fujian province supporting Hubei province during the COVID-19 pandemic
Authors: Yongxi Wu , Zexin Lin , Yiqi Lin , Qianwen Lin , Xiaoliang Xie , Shichao Wei
Published: July 2024

Objective

To explore the impact of COVID-19 on the sleep of healthcare workers from Fujian Province supporting Hubei Province and its related risk factors.

Methods

A cross-sectional, anonymous, self-reported online questionnaire survey was conducted among all participants. The questionnaire consisted of five parts: sociodemographic characteristics and COVID-19 epidemic-related factors, Pittsburgh Sleep Quality Index (PSQI), Epworth Sleepiness Scale (ESS), Morningness-Eveningness Questionnaire-5 (MEQ-5), and 12-item General Health Questionnaire (GHQ-12).

Results

Among 552 participants, 203 (36.8%) had a PSQI score > 7, indicating the presence of sleep disorders. Logistic regression analysis revealed that sleep disorders were independently associated with a history of previously diagnosed sleep disorders (OR 6.074, 95% CI 2.626–14.049, P < 0.001), rotating night shifts > 3 times per week (OR 3.089, 95% CI 1.650–5.781, P < 0.001), using electronic devices before sleep >1 h (OR 1.685, 95% CI 1.131–2.511, P = 0.010), concern about contracting COVID-19 (OR 1.116, 95% CI 1.034–1.204, P = 0.005), perception of societal support for supporting healthcare workers in Hubei (OR 0.861,95% CI 0.744–0.998, P = 0.047) (OR 0.861, 95% CI 0.744–0.998, P = 0.047), non-medical staff (OR 0.257, 95% CI 0.067–0.987, P = 0.048), ESS score (OR 1.068, 95% CI 1.018–1.121, P = 0.007), and GHQ-12 score (OR 1.511, 95% CI 1.281–1.782, P < 0.001).

Conclusion

Sleep disorders were highly prevalent among healthcare workers from Fujian Province supporting Hubei Province during the COVID-19 pandemic. Risk factors for sleep disorders included a history of previously diagnosed sleep disorders, rotating night shifts > 3 times per week, using electronic devices before sleep >1 h, excessive concern about contracting COVID-19, and poorer psychological health. Higher perceived societal support and understanding of support for healthcare workers supporting Hubei were associated with a reduced risk of sleep disorders, as was being non-medical staff. Providing more sleep hygiene education and psychological health services for frontline healthcare workers is necessary.
A cross-cultural analysis of spiritual transcendence and its impact on job satisfaction, job security, and life satisfaction in Bali and Türkiye: mediator effect of earthquake anxiety
Authors: Subawa Nyoman Sri , Baykal Elif , Basmantra Ida Nyoman , Mimaki Caren Angellina , Yorulmaz Halil
Published: July 2024

Earthquakes are considered as a major factor causing PTSD, anxiety, and depression across various age groups. Increased anxiety stemming from earthquakes may prompt individuals to turn to spirituality as a coping mechanism, with spiritual transcendence believed to be an effective way to mitigate anxiety. In this study, Bali, which has a Far Eastern spiritual tradition, and Türkiye, the majority of whose population is Muslim, are discussed comparatively. In fact, the underlying reason for this choice is to examine whether there is a difference between Hindu belief, one of the Far Eastern religions as a spiritual tradition, and Islam, one of the monotheistic religions, regarding individuals’ ability to manage anxiety and some basic psychological reactions to the fear of earthquakes. An example of Bali’s Hindu tradition has been considered a representation of the Islamic tradition, one of the monotheistic religions in Türkiye. Given this phenomenon, the study took a quantitative approach, giving a novel conceptual framework for understanding the relationship between spiritual transcendence, seismic fear, job satisfaction, job security, life satisfaction, and the moderating influence of optimism. Empirical data were acquired via surveys issued via Google Form to a total of 913 workers in Bali and Türkiye. The research data were analyzed using SmartPLS software and a structural equation modeling technique. Findings indicate that earthquake anxiety and the impact of spiritual transcendence on satisfaction and job security are stronger in Bali than in Türkiye. Additionally, spirituality holds greater significance for the Balinese sample compared to the Turkish sample. The study clarifies the implications of its findings and provides guidance for future research endeavors.
Case report: two cases of rhabdomyolysis following esketamine treatment
Authors: Zeiss René , Schweizer Melissa , Connemann Bernhard , Malejko Kathrin
Published: July 2024

Major depressive disorder is a mental disorder affecting millions of people worldwide. A considerable proportion of patients demonstrate a lack of response to conventional treatment. With the recent introduction of esketamine, a new treatment option has been approved for treatment-resistant depression. Although the medication is efficacious in a substantial portion of cases, rare, but possibly serious, adverse effects may occur. This case series shows two cases of rhabdomyolysis, a destruction of muscle tissue with elevated creatine kinase levels, after administration of esketamine. The first case presented is about a 33 year old male patient who suffered from a severe episode of a depressive disorder. He got nasal esketamine as an emergency treatment. While there was an initial improvement regarding the depressive symptoms, the patient developed muscle pain and fatigue after the administration of the fourth dose, with creatine kinase (CK) levels above 22,000 U/L, indicating rhabdomyolysis. Following the discontinuation of esketamine and the implementation of supportive care, the CK levels returned to normal and the depressive symptoms abated. The second case is about a 22-year-old male patient who also suffered from a severe depressive episode and got eketamine as an emergency treatment. Following the tenth dose, the patient exhibited muscle weakness and elevated CK levels (8,032 U/L), which persisted even after dose reduction. Esketamine administration was stopped, and the following monitoring demonstrated a slow return to normal levels of CK and liver enzymes. In both cases, there was no known medical history and both patients developed rhabdomyolysis after administration of esketamine. The temporal connection suggests a possible causal relationship. We found no literature on esketamine-induced rhabdomyolysis following the administration of nasal esketamine. However, these two cases emphasize the need of monitoring for laboratory changes like elevated CK-levels in patients receiving esketamine, especially considering its growing use in treatment-resistant depression.
Application of improved harmonic Poisson segmented regression model in evaluating the effectiveness of Kala-Azar intervention in Yangquan City, China
Authors: Hao Chongqi , Zhao Zhiyang , Zhang Peijun , Wu Bin , Ren Hao , Wang Xuchun , Qiao Yuchao , Cui Yu , Qiu Lixia
Published: July 2024

Background

The Centre for Disease Control and Prevention in Yangquan, China, has taken a series of preventive and control measures in response to the increasing trend of Kala-Azar. In response, we propose a new model to more scientifically evaluate the effectiveness of these interventions.

Methods

We obtained the incidence data of Kala-Azar from 2017 to 2021 from the Centre for Disease Control and Prevention (CDC) in Yangquan. We constructed Poisson segmented regression model, harmonic Poisson segmental regression model, and improved harmonic Poisson segmented regression model, and used the three models to explain the intervention effect, respectively. Finally, we selected the optimal model by comparing the fitting effects of the three models.

Results

The primary analysis showed an underlying upward trend of Kala-Azar before intervention [incidence rate ratio (IRR): 1.045, 95% confidence interval (CI): 1.027–1.063, p < 0.001]. In terms of long-term effects, the rise of Kala-Azar slowed down significantly after the intervention (IRR:0.960, 95%CI:0.927–0.995, p = 0.026), and the risk of Kala-Azar increased by 0.3% for each additional month after intervention (β1 + β3 = 0.003, IRR = 1.003). The results of the model fitting effect showed that the improved harmonic Poisson segmental regression model had the best fitting effect, and the values of MSE, MAE, and RMSE were the lowest, which were 0.017, 0.101, and 0.130, respectively.

Conclusion

In the long term, the intervention measures taken by the Yangquan CDC can well curb the upward trend of Kala-Azar. The improved harmonic Poisson segmented regression model has higher fitting performance, which can provide a certain scientific reference for the evaluation of the intervention effect of seasonal infectious diseases.
Systematic review of bovine and zoonotic tuberculosis in the Western Pacific and the Southeast Asia regions of the World Health Organization
Authors: Singh Balbir B. , Dhand Navneet K. , Cadmus Simeon , Dean Anna S. , Merle Corinne S.
Published: July 2024

Introduction

Tuberculosis (TB) remains a leading cause of mortality worldwide. We conducted this systematic review to understand the distribution of bovine and zoonotic tuberculosis in the World Health Organization (WHO)’s Southeast Asia Region (SEAR) and Western Pacific Region (WPR) to inform our understanding of the risk posed by this disease.

Methods

A two-pronged strategy was used by evaluating data from peer-reviewed literature and official reports. A systematic search was conducted using a structured query in four databases (Web of Science, Scopus, Medline, and PubMed) to identify any reports of the occurrence of zoonotic TB. No language and time constraints were used during the search, but non-English language articles were later excluded. The official data were sourced from the World Organization for Animal Health’s (WOAH) World Animal Health Information System (WAHIS) and WHO’s global TB database.

Results

The retrieved records from SEAR and WPR (n = 113) were screened for eligibility, and data about disease occurrence were extracted and tabulated. In SEAR, all of the five studies that conducted Mycobacterium speciation (5/6) in humans were from India, and the reported Mycobacterium species included M. tuberculosis, M. bovis, M. scrofulacium, M. kansasii, M. phlei, M. smegmatis and M. orygis. In WPR, Mycobacterium speciation investigations in humans were conducted in Australia (8), China (2), Japan (2), NewZealand (2) and Malaysia (1), and the reported Mycobacterium species included M. bovis, M. africanum and M. tuberculosis. Seven countries in WHO’s SEAR have officially reported the occurrence of Mycobacterium bovis in their animals: Bangladesh, India, Indonesia, Myanmar, Nepal, Sri Lanka and Thailand. In WPR, the WAHIS information system includes reports of the identification of M. bovis from 11 countries – China, Fiji, Japan, Malaysia, Mongolia, New Zealand, the Philippines, the Republic of Korea, Singapore, Tonga and Viet Nam. In contrast, human zoonotic TB cases in the WHO database were only listed from Australia, Brunei Darussalam and Palau countries.

Discussion

The available data suggests under-reporting of zoonotic TB in the regions. Efforts are required to strengthen zoonotic TB surveillance systems from both animal and human health sides to better understand the impact of zoonotic TB in order to take appropriate action to achieve the goal of ending the TB epidemic.
Building capacity for local public health: lessons from a mixed-methods evaluation of an academic-public health partnership used in response to COVID-19
Authors: Fielman Sarah , Elliott Patricia A. , Codner Alyson , Abousleiman Hiba , Cogan Ally , Wangstrom Zoë , Greece Jacey A.
Published: July 2024

Introduction

The Massachusetts Academic Health Department Consortium (AHD) established the Academic Public Health Volunteer Corps (APHVC) to support Local Health Departments (LHDs, n = 351) to meet rapidly emerging needs during the COVID-19 pandemic through engaging student volunteers. A program evaluation captured lessons learned and informed recommendations for sustainability and future replication.

Methods

The mixed-methods evaluation leveraged the Consolidated Framework for Implementation Research (CFIR). Data were stratified by LHD engagement with APHVC. Quantitative surveys informed probes for qualitative focus groups and interviews; findings were categorized into CFIR constructs using a deductive approach.

Results

One-fifth of LHDs (n = 76, 27 used APHVC services, 45 did not) completed the survey. Eleven employees participated in follow-up focus groups or interviews. APHVC filled resource gaps, built capacity, and provided high-quality deliverables. LHDs experienced issues with reliability and communication of volunteers and lacked time to train volunteers.

Conclusions

CFIR aided in evaluating APHVC in real time, producing actionable recommendations for best practices, dissemination, and future iterations of the program. Results are being used to enhance program effectiveness and sustainability, community health, and health equity across Massachusetts, and may help inform academic practice-based programs across the United States.
Spatial and temporal characteristic of PM2.5 and influence factors in the Yellow River Basin
Authors: Han Li , Han Meng , Wang Yiwen , Wang Hua , Niu Jiqiang
Published: July 2024

The Yellow River Basin has been instrumental in advancing ecological preservation and fostering national high-quality development. However, since the advent of China’s reform and opening-up policies, the basin has faced severe environmental pollution issues. This study leverages remote sensing data from 1998 to 2019. As per the “Basin Scope and Its Historical Changes” published by the Yellow River Conservancy Commission of the Ministry of Water Resources, the Yellow River Basin is categorized into upstream, midstream, and downstream regions for analysis of their spatial and temporal distribution traits using spatial autocorrelation methods. Additionally, we employed probes to study the effects of 10 factors, including mean surface temperature and air pressure, on PM2.5. The study findings reveal that (1) the annual average concentration of PM2.5 in the Yellow River Basin exhibited a fluctuating trend from 1998 to 2019, initially increasing, then decreasing, followed by another increase before ultimately declining. (2) The air quality in the Yellow River Basin is relatively poor, making it challenging for large-scale areas with low PM2.5 levels to occur. (3) The PM2.5 concentration in the Yellow River Basin exhibits distinct high and low-value concentration areas indicative of air pollution. Low-value areas are predominantly found in the sparsely populated central and southwestern plateau regions of Inner Mongolia, characterized by a better ecological environment. In contrast, high-value areas are prevalent in the inland areas of Northwest China, with poorer natural conditions, as well as densely populated zones with high energy demand and a relatively developed economy. (4) The overall population density in the Yellow River Basin, as well as in the upstream, midstream, and downstream regions, serves as a primary driving factor. (5) The primary drivers in the middle reaches and the entire Yellow River Basin remain consistent, whereas those in the upper and lower reaches have shifted. In the upstream, air pressure emerges as a primary driver of PM2.5, while in the downstream, NDVI and precipitation become the main influencing factors.
Effects of fermented unconventional protein feed on pig production in China
Authors: Sun Haoxuan , Jiang Zipeng , Chen Zhimin , Liu Guohua , Liu Zexue
Published: July 2024

Unconventional protein feeds, characterized by low nutritional value, high variability, and poor palatability, have limited their application in swine production. Fermentation technology holds the key to addressing these shortcomings. Given the ban on antibiotics in China, the inferior quality of imported pig breeds, and long-term dependence on imported soybean, the prospects for fermented unconventional protein feeds are promising. This paper delves into the common types of fermented unconventional protein feeds, factors influencing the fermentation process, the mechanisms by which they enhance swine health, and the challenges and prospects of fermented feeds, offering theoretical insights for the future development of the feed industry.
Quantification of metallic artifact on CT associated with titanium pedicle screws
Authors: Lewis M. J. , Early P. J. , Bergman R. , Love K. , Nelson N.
Published: July 2024

Background

In dogs undergoing vertebral column stabilization, post-operative computed tomography (CT) evaluates implant placement. The impact on the interpretation of metallic artifact associated with titanium implants in dogs remains to be established. Our objective was to quantify metallic artifact on CT associated with titanium pedicle screws.

Methods

The study design included an in vitro model and a retrospective review of 11 dogs with vertebral column stabilization. Twenty four titanium pedicle screws (6 each: 2.0 mm, 2.7 mm, 3.5 mm, and 4.5 mm) were inserted into a 20% ballistic gel, and CT scan of the construct was performed. Three blinded raters used a bone window to measure the maximum width (effective size) of each screw, one rater measured effective size using an ultrawide window and 45 titanium pedicle screws (3×2.0 mm, 5×2.7 mm, 30×3.5 mm, and 7×4.5 mm) in 11 clinical cases. Effective size measurements were compared to actual screw sizes.

Results

The effective size was 26.9–43.8%, 9.2–18.5%, and 21.1–30.5% larger than the actual size for the in vitro system (bone window), in vitro system (ultrawide window), and clinical cases, respectively. The mean gross difference for the in vitro measurements varied by implant size (p < 0.001) and was positively correlated with implant size (r = 0.846), but the mean percentage difference was negatively correlated with implant size (p < 0.001). Overestimation was larger for the in vitro model bone window compared to the ultrawide window (p < 0.001) and clinical cases (p = 0.001).

Conclusion

Metallic artifact associated with titanium pedicle screws on CT resulted in an overestimation of screw size. This information might aid in the interpretation of implant placement on post-operative imaging.
John Adams – amerykański Cyceron? Z genealogii Res publica Americana
Authors: Tulejski Tomasz , Banach Tomasz
Published: July 2024

When creating a new republic, the Foundings Fathers deemed it necessary to become well versed in the lessons of history, in order to avoid the fates of previous republics. Above all other historical corollaries, Americans evoked the example of the republican Rome that had upheld a system of government that aspired to ordered liberty as supported by a mixture of public civic virtue and effective institutional design for nearly five centuries. The comparisons were possible because the American colonies had kept the grammar school system of education then common in England, giving all educated Americans a basic grasp of Cicero’s reputation and writings, who represented eloquence, moral virtue and hostility towards tyranny. He thus became a source of inspiration for the Founders, and John Adams directly considered himself an American Cicero. In the article, the authors try to answer the question about the legitimacy of such a position of the 2nd President of the US. To do this, they compare the basic political categories of Cicero and Adams, pointing out their similarities and differences. They also examine to what extent Cicero’s thought could be applied to the reality of the young American republic.
Species-Dependent Response of Brassica chinensis L. to Elevated CO2 Gradients Influences Uptake and Utilization of Soil Nitrogen, Phosphorus and Potassium
Authors: Shi Songmei , Wang Xinju , Li Huakang , Song Jiajun , He Xinhua , Yang Zhengan
Published: July 2024

Employing elevated CO2 (eCO2), similar to increasing atmospheric CO2 in a greenhouse, is a common practice used to increase vegetable crop yields. However, the responses of nutrient availability, nutrient uptake and use efficiency in leafy vegetables to eCO2 remain largely unknown. The plant biomass production, nitrogen (N), phosphorus (P) and potassium (K) contents, nutrient uptake, and soil enzymatic activities of three Brassica chinensis varieties of ‘Longpangqing’, ‘Heimeiren’ and ‘Qingjiangbai’ were thus assessed under ambient CO2 (C0, 420/470 ppm, day/night) and eCO2 (C1, C0 + 33.3%C0; C2, C0 + 66.7%C0; and C3, C0 + 100%C0) for 4 months. Biomass production was significantly enhanced in these three tested B. chinensis varieties along with eCO2 gradients, with the highest biomass production under C3. Moreover, the eCO2 significantly increased plant N and K uptake, P and K use efficiency, soil saccharase, urease, and phosphatase activities, but decreased plant P content, soil available N and K, and catalase activity. Under eCO2, ‘Qingjiangbai’ exhibited higher biomass production and P and K uptake, without a decrease in soil available N and P. Consequently, more external fertilizer supplementation (especially N, followed by K) is required to maintain or promote Brassica chinensis yield under eCO2, while these management strategies must be carefully considered for different crop varieties.
A Retrospective Study of Sildenafil Administration in 55 Cats with Cardiopulmonary Disease (2009–2021)
Authors: Huynh Jasmine , Dolan Samantha , Karlin Emily T. , Freeman Lisa M. , Rozanski Elizabeth A. , Rush John E.
Published: July 2024

Sildenafil is a drug used to successfully manage a variety of cardiopulmonary disorders in people and dogs, but there is limited information on its use in cats. The objective was to review the medical records of cats that received sildenafil as part of their clinical management. Medical records and pharmacy databases were searched for cats that received sildenafil for ≥24 h between 2009 and 2021, and data were collected from medical records. Fifty-five cats received sildenafil for ≥24 h and were included in the study: 43 with primary cardiac disease (acquired, n = 28; congenital, n = 15) and 12 with primary respiratory disease. Side effects possibly attributed to sildenafil were identified in two cats (systemic hypotension, n = 1; polydipsia, n = 1), and sildenafil was discontinued in the cat with hypotension. Sildenafil was discontinued in an additional three cats due to a lack of improvement in clinical signs. No cat was documented to develop worsening pulmonary edema within 72 h of starting sildenafil. Median duration of sildenafil administration was 87 days (range, 2–2362 days). Sildenafil administration in cats appeared to be generally well-tolerated. Studies are needed to determine whether sildenafil administration to cats with cardiopulmonary disease improves the quality of life or survival times.
The Influence of Selected Environmental Factors on the Number of Somatic Cells in Cistern and Alveolar Milk of Polish Holstein-Friesian Cows
Authors: Guliński Piotr , Kroszka Michał Kacper
Published: July 2024

The aim of the study was to evaluate the influence of the milking phase on somatic cell count (SCC) in milk obtained from the cisternal and alveolar parts of udders of selected Polish Holstein-Friesian cows. The study also assessed the impact of other genetic and environmental factors on SCC variability in cisternal and alveolar milk, including: the individual cow, lactation stage, age of cow, production level, milking speed, fat-to-protein ratio, and milking type. The research included 15 cows of Polish Holstein-Friesian breed at different ages, lactation stages, and with varying daily milk yield. A total of 210 milk observations were conducted, including 105 for 1 min milking and 105 for 8 min milking. The results obtained in the study indicated that milk obtained during two different milking phases exhibited similar SCC levels (F for LOGSCC = 0.79). The average actual SCC in milk produced by 15 cows in 105 observations for 1 min milking was 219,000 cells/mL, while for 8 min milking it was 229,000 cells/mL. The results were inconclusive, suggesting that SCC in cisternal and alveolar milk must be influenced by factors other than the milking phase. The analysis of variance conducted for this purpose provided the basis for stating a highly statistically significant effect of the individual cow (F for LOGSCC = 147.9), lactation stage (F for LOGSCC = 54.64), age of cow (F for LOGSCC = 12.39), daily production level (F for LOGSCC = 34.49), milking speed (F for LOGSCC = 17.56), and fat-to-protein ratio (F for LOGSCC = 22.99) on the variability of characteristics defining SCC in milk. In summary, SCC is characterized by high variability, influenced by a range of environmental and genetic factors such as the individual cow, lactation stage, age of cow, milking speed, and dietary fat-to-protein ratio. The influence of milking phase (1 min or 8 min) and milking type (morning or evening) should be considered inconclusive based on the entire population studied. For half of the cows, SCC in cisternal milk was higher than in alveolar milk, while for the other half, the situation was reversed. Further observations are required to confirm the hypothesis regarding the extent to which cows’ immunological response to bacterial infections is concentrated in the cisternal or alveolar part of the udder under national environmental conditions.
Epidemiology and Genetic Characterization of Porcine Parvovirus 7 Recovered from Swine in Hunan, China
Authors: Wang Dongliang , He Qing , Wang Naidong , Mai Jinhui
Published: July 2024

Porcine parvovirus 7 (PPV7) was first discovered in swine in 2016, and PPV7 infection has been detected in aborted pig fetuses and in sows that experienced reproductive failure. The objective of this study was to report the prevalence and genetic characterization of PPV7 in Hunan, China. Seventy of the four hundred and twenty-two (16.6%) serum, semen, and tissue samples collected from pigs were positive for PPV7. One complete PPV7 strain and eighteen complete cap gene sequences were obtained; nucleotide and amino acid identity among the nineteen Cap sequences were 88.1–99.4% and 88.1–100%, respectively. They shared identity with previously discovered sequences ranging from 86.6 to 98.9% and 83.7 to 99.8% at the nucleotide- and amino acid-level, respectively. The phylogenetic tree analysis exhibited that PPV7 strains had two major groups based on the presence or absence of five amino acid (181–185) insertions on the Cap protein. Analysis of the Cap protein demonstrated that PPV7 Cap had significant variability, implying that PPV7 evolved at high substitution rates. Substantial variations of that PPV7 Cap may enable the emergence of newly mutated capsid profiles due to its viral adaptation to host responses. Furthermore, antigenic alteration owing to PPV7 Cap protein amino acid mutations at immune epitopes may enable viruses to escape from the host’s immune system. This study determined the prevalence and genetic characteristics of PPV7 circulating in swine in Hunan, China, and provided the impetus and basis to further investigate the pathogenicity and epidemiology of PPV7.
Validation and Application of a Code for Three-Dimensional Analysis of Hydrogen–Steam Behavior in a Nuclear Reactor Containment during Severe Accidents
Authors: Kim Jongtae , Lim Kukhee
Published: July 2024

In a pressurized water reactor (PWR) during a loss of coolant accident (LOCA) or a station blackout (SBO) accident, water and steam are released into the containment building. The water vapor mixes with the atmosphere, partially condensing into droplets or condensing on the containment walls. Although a significant amount of water vapor condenses, it coexists with hydrogen generated by the reactor core oxidation. As water vapor condenses, the volume fraction of hydrogen increases, raising the risk of explosion or flame acceleration. As such, water vapor’s behavior directly affects hydrogen distribution. To conservatively evaluate hydrogen safety in a PWR during a severe accident, lumped-parameter codes have been heavily used. As a best-estimate approach for hydrogen safety analysis in a PWR containment, a turbulence-resolved CFD code called contain3D has been developed. This paper presents the validation results of the code and simulation results of hydrogen behavior affected by water vapor condensation and hydrogen removal by passive autocatalytic recombiners (PARs) in the APR1400 containment. The results provide insight into the three-dimensional behaviors of the hydrogen in the containment.
A Survey of of Side-Channel Attacks and Mitigation for Processor Interconnects
Authors: Yuan Jie , Zhang Jing , Qiu Pengfei , Wei Xinghai , Liu Dongxiao
Published: July 2024

With advancements in chip technology, the number of cores in modern commercial processors continues to rise, leading to increased complexity in interconnects and on-chip networks. This complexity, however, exposes significant security vulnerabilities, primarily in the form of side-channel and covert-channel exploits. Unlike other microarchitectural side-channel attacks, those leveraging on-chip interconnects utilize unique characteristics, allowing attackers to develop novel methods that can bypass existing effective defenses. In this paper, we present a comprehensive survey of current side-channel and covert-channel attacks based on processor-on-chip interconnects. We categorize these attacks into three types: contention-based, distance-based, and layout-based, according to the specific interconnect characteristics they exploit, and discuss corresponding countermeasures for each. Finally, we provide an outlook on future development trends in processor interconnect side channels. This survey is the first to specifically focus on interconnect-based side channels in processors.
Polynomial Fitting-Based Noise Reduction for Correlation Functions in Medium-Frequency Radar
Authors: Chen Jinsong , Zhang Yang , Wang Liming , Kang Guoqin , Li Na , Wei Junfeng
Published: July 2024

In the theoretical calculation of atmospheric wind fields using the cross-correlation analysis method of Medium-Frequency radar, it is necessary to compute a series of correlation parameters from the received echo signals, such as autocorrelation and cross-correlation functions, within the main lobe range of the antenna array to retrieve atmospheric parameters. However, both theoretical analysis and practical applications have shown that the shape of correlation functions can be affected by atmospheric conditions and receiver noise, leading to significant biases in the estimated correlation parameters within the main lobe range. In this study, we theoretically analyze the influence of noise on the amplitude of autocorrelation and cross-correlation functions. We propose a noise reduction method based on the characteristics of correlation functions at the zero-delay point to calculate the noise factor and process the correlation functions within the main lobe range. Furthermore, we conduct simulation analysis to evaluate the performance of this noise reduction method and summarize the effects of the number of fitting points and fitting methods on the noise reduction performance.
The Environmental Consequences of Engine Emissions in Air and Road Transport
Authors: Kováčiková Kristína , Novák Andrej , Novák Sedláčková Alena , Kováčiková Martina
Published: July 2024

This study evaluated the environmental consequences of engine emissions from road and air transport on three commonly traveled routes between Berlin and the cities of Frankfurt, Paris, and Barcelona. The focus was on CO2 emissions due to their significant impact on climate change. By collecting and analyzing comprehensive data on vehicle and aircraft emissions, this study aimed to compare the CO2 output of each transport mode under different passenger load scenarios. The findings indicate that air transport is generally more efficient in terms of CO2 emissions per passenger for longer distances. For instance, the CO2 emissions per passenger ranged from 22.6 kg to 79.8 kg for air transport and from 64.7 kg to 220.8 kg for road transport, demonstrating reductions of approximately 65% to 72%. This study underscores the importance of considering both distance and passenger load when evaluating the environmental impact of different transport modes and highlights the need for a multifaceted approach to reducing transport emissions, including technological innovations, policy interventions, and behavioral changes.
Optimization of High-Temperature CO2 Capture by Lithium Orthosilicate-Based Sorbents Using Response Surface Methodology
Authors: Stefanelli Eleonora , Francalanci Flavio , Vitolo Sandra , Puccini Monica
Published: July 2024

The major challenge in the current context of the rising world energy demand is to limit the global temperature increase for mitigating climate change. This goal requires a large reduction of CO2 emissions, mainly produced by power generation and industrial processes using fossil fuels. In this study, a novel methodology for K2CO3-doped Li4SiO4 sorbents production for CO2 capture at high temperatures was adopted based on the Design of Experiments (DoE). This innovative approach systematically tested different synthesis (temperature and K2CO3 content) and adsorption conditions (sorption temperature and CO2 concentration), allowing for the assessment of individual and interactive effects of process parameters. The Response Surface Methodology (RSM) was employed to obtain non-linear predictive models of CO2 uptake and Li4SiO4 conversion. The results of RSM analysis evidenced a maximum adsorption capacity of 196.4 mg/g for a sorbent produced at 600 °C and with 36.9 wt% of K2CO3, tested at 500 °C and 4 vol% of CO2. Whereas at 50 vol% of CO2, the best uptake of 295.6 mg/g was obtained with a sorbent synthesized at 600 °C, containing less K2CO3 (17.1 wt%) and tested at a higher temperature (662 °C). These findings demonstrate that K2CO3-doped Li4SiO4 sorbents can be tailored to maximize CO2 capture under various operating conditions, making them suitable for use in industrial processes.
Cerebral Protection Strategies in Aortic Arch Surgery—Past Developments, Current Evidence, and Future Innovation
Authors: Werner Paul , Winter Martin , Mahr Stephané , Stelzmueller Marie-Elisabeth , Zimpfer Daniel , Ehrlich Marek
Published: July 2024

Surgery of the aortic arch remains a complex procedure, with neurological events such as stroke remaining its most dreaded complications. Changes in surgical technique and the continuous innovation in neuroprotective strategies have led to a significant decrease in cerebral and spinal events. Different modes of cerebral perfusion, varying grades of hypothermia, and a number of pharmacological strategies all aim to reduce hypoxic and ischemic cerebral injury, yet there is no evidence indicating the clear superiority of one method over another. While surgical results continue to improve, novel hybrid and interventional techniques are just entering the stage and the question of optimal neuroprotection remains up to date. Within this perspective statement, we want to shed light on the current evidence and controversies of cerebral protection in aortic arch surgery, as well as what is on the horizon in this fast-evolving field. We further present our institutional approach as a large tertiary aortic reference center.
Learning a Memory-Enhanced Multi-Stage Goal-Driven Network for Egocentric Trajectory Prediction
Authors: Wu Xiuen , Li Sien , Wang Tao , Xu Ge , Papageorgiou George
Published: July 2024

We propose a memory-enhanced multi-stage goal-driven network (ME-MGNet) for egocentric trajectory prediction in dynamic scenes. Our key idea is to build a scene layout memory inspired by human perception in order to transfer knowledge from prior experiences to the current scenario in a top-down manner. Specifically, given a test scene, we first perform scene-level matching based on our scene layout memory to retrieve trajectories from visually similar scenes in the training data. This is followed by trajectory-level matching and memory filtering to obtain a set of goal features. In addition, a multi-stage goal generator takes these goal features and uses a backward decoder to produce several stage goals. Finally, we integrate the above steps into a conditional autoencoder and a forward decoder to produce trajectory prediction results. Experiments on three public datasets, JAAD, PIE, and KITTI, and a new egocentric trajectory prediction dataset, Fuzhou DashCam (FZDC), validate the efficacy of the proposed method.
Time-Dependent Reliability Analysis of Anhydrite Rock Tunnels under Swelling Conditions: A Study on Stress, Deformation, and Engineering Solutions
Authors: Zan Zihui , Wang Ran , Zhao Yunfeng , Wu Jianxun , Hou Zhenkun
Published: July 2024

This study presents an analytical approach for evaluating the reliability of anhydrite rock tunnels, focusing on their characteristic swelling behavior. Anhydrite rocks, prone to significant expansion upon moisture exposure, pose a challenge in tunnel construction, potentially leading to structural issues such as floor heave and lining damage. To address this, this research develops an elastic swelling analytical solution based on humidity stress field theory, enabling the assessment of time-dependent stress and deformation changes in anhydrite tunnels. The solution’s applicability is demonstrated through its application to the Lirang tunnel. The investigation into the effects of support pressure, swelling time, and reserved deformation on tunnel reliability reveals that circumferential stress at the tunnel wall increases by 13.94% and 21.86% for swelling periods of 30 and 365 days, respectively. Similarly, radial displacement escalates by 22.97% and 35.93% over these periods, highlighting the significant impact of swelling behavior. Using a spreadsheet-based First Order Reliability Method (FORM) for analysis, this study finds that the original design of the Lirang tunnel did not meet the desired reliability standards under swelling conditions. However, strategic adjustments in construction variables, such as increasing support pressure to 1.2 MPa or enhancing reserved deformation to 59 mm, elevated the tunnel’s reliability to meet safety requirements. This research provides a vital framework for assessing and enhancing the reliability of anhydrite rock tunnels, considering the long-term effects of swelling. It underscores the importance of incorporating swelling behavior in the design and construction of tunnels in anhydrite rock formations, offering valuable insights for optimizing tunnel stability in such challenging geological conditions.
Indirect Voltammetry Detection of Non-Electroactive Neurotransmitters Using Glassy Carbon Microelectrodes: The Case of Glutamate
Authors: Galindo Sandra , Nimbalkar Surabhi , Oyawale Alexis , Bunnell James , Cuacuas Omar , Montgomery-Walsh Rhea , Rohatgi Amish , Cariappa Brinda , Gautam Abhivyakti , Peguero-Garcia Kevin , Lee Juyeon , Bisgaard Stephanie , Faucher Carter , Keller Stephan , Kassegne Sam
Published: July 2024

Glassy carbon (GC) microelectrodes have been successfully used for the detection of electroactive neurotransmitters such as dopamine and serotonin through voltammetry. However, non-electroactive neurotransmitters such as glutamate, lactate, and gamma-aminobutyric acid (GABA) are inherently unsuitable for detection through voltammetry techniques without functionalizing the surface of the microelectrodes. To this end, we present here the immobilization of the L-glutamate oxidase (GluOx) enzyme on the surface of GC microelectrodes to enable the catalysis of a chemical reaction between L-glutamate, oxygen, and water to produce H2O2, an electroactive byproduct that is readily detectable through voltammetry. This immobilization of GluOx on the surface of bare GC microelectrodes and the subsequent catalytic reduction in H2O2 through fast-scan cyclic voltammetry (FSCV) helped demonstrate the indirect in vitro detection of glutamate, a non-electroactive molecule, at concentrations as low as 10 nM. The functionalized microelectrodes formed part of a four-channel array of microelectrodes (30 μm × 60 μm) on a 1.6 cm long neural probe that was supported on a flexible polymer, with potential for in vivo applications. The types and strengths of the bond between the GC microelectrode surface and its functional groups, on one hand, and glutamate and the immobilized functionalization matrix, on the other hand, were investigated through molecular dynamic (MD) modeling and Fourier transform infrared spectroscopy (FTIR). Both MD modeling and FTIR demonstrated the presence of several covalent bonds in the form of C-O (carbon–oxygen polar covalent bond), C=O (carbonyl), C-H (alkenyl), N-H (hydrogen bond), C-N (carbon–nitrogen single bond), and C≡N (triple carbon–nitrogen bond). Further, penetration tests on an agarose hydrogel model confirmed that the probes are mechanically robust, with their penetrating forces being much lower than the fracture force of the probe material.
The Role of the MiR-181 Family in Hepatocellular Carcinoma
Authors: Chen Jinbiao , Liu Ken , Vadas Mathew A. , Gamble Jennifer R. , McCaughan Geoffrey W.
Published: July 2024

Hepatocellular carcinoma (HCC) is the fourth-leading cause of cancer-related death worldwide. Due to the high mortality rate in HCC patients, discovering and developing novel systemic treatment options for HCC is a vital unmet medical need. Among the numerous molecular alterations in HCCs, microRNAs (miRNAs) have been increasingly recognised to play critical roles in hepatocarcinogenesis. We and others have recently revealed that members of the microRNA-181 (miR-181) family were up-regulated in some, though not all, human cirrhotic and HCC tissues—this up-regulation induced epithelial–mesenchymal transition (EMT) in hepatocytes and tumour cells, promoting HCC progression. MiR-181s play crucial roles in governing the fate and function of various cells, such as endothelial cells, immune cells, and tumour cells. Previous reviews have extensively covered these aspects in detail. This review aims to give some insights into miR-181s, their targets and roles in modulating signal transduction pathways, factors regulating miR-181 expression and function, and their roles in HCC.
Neck Circumference as a Valuable Tool to Identify the Risk of Metabolic Syndrome in Mexican Children
Authors: Valencia-Sosa Evelyn , González-Pérez Guillermo Julián , Chávez-Palencia Clío , Vega-López María Guadalupe , Romero-Velarde Enrique
Published: July 2024

Background/Objectives: Neck circumference (NC) has been proposed as a simple measurement to identify patients with overweight and obesity. It has been found that adipose tissue at the cervical level is associated with the presence of metabolic alterations. The aim of this study was to estimate the association between NC and indicators of Metabolic Syndrome (MS) to subsequently estimate its capacity to identify the risk of MS compared to waist circumference (WC) and Body Mass Index (BMI). Methods: A cross-sectional study was carried out with a sample of 286 children 6–9 years old who attended six public primary schools in Jalisco, Mexico. Pearson’s correlation coefficients along with sensitivity and specificity tests were performed to analyze the relationship between NC and MS indicators. Odds ratio (OR) and concordance analyses were performed considering the Kappa index. Results: NC showed statistically significant correlations with all MS indicators except for LDL cholesterol and total cholesterol. The cut-off points of NC to identify MS according to sex was >27.4 cm for girls and >29.8 cm for boys. The association of NC with values above the cutoff point and the presence of MS was OR: 21.6 (CI: 7.11–65.74). Conclusions: NC represents a simple and cost-effective alternative to identify children at risk of MS when compared to BMI and WC.
On the Role of the Building Envelope on the Urban Heat Island Mitigation and Building Energy Performance in Mediterranean Cities: A Case Study in Southern Italy
Authors: Martinelli Alessandra , Carlucci Francesco , Fiorito Francesco
Published: July 2024

The urban heat island (UHI) effect is one of the largest climate-related issues concerning our cities due to the localized temperature increase in highly urbanized areas. This paper aims to investigate the impact of UHI mitigation techniques in promoting climate resilience, by reducing urban air temperatures and cooling energy consumption in buildings. To this end, four mitigation solutions regarding the building envelope—green roofs, green walls, cool roofs, and cool walls—were investigated for the city of Bari in Southern Italy and compared with the current baseline scenario. Hence, five scenarios were simulated—using the ENVI-met microclimate software—during three representative summer days, and the resulting microclimate changes were assessed. Based on these analyses, new climate files—one for each scenario—were generated and used as input to run energy simulations in EnergyPlus to estimate the building cooling consumption. Coupling the microclimate and the consumption outcomes, the mitigation strategies were evaluated from both an urban and building point of view. The study shows that urban characteristics, mainly geometry and materials, are crucial for the UHI phenomenon. All the applied technologies seem to be effective. However, green walls proved to be more efficient in reducing outdoor temperatures (1 °C reduction in daily temperatures), while cool walls performed better in reducing cooling energy consumption, with an overall saving of 6% compared to the current scenario.