bluuebunny/crossref_metadata_2025 huggingface dataset:
The Main Department of Appanages and the Problem of Supplemental Payments to Construction Contractors for Office Buildings in Livadia
Authors: Efimov Andrey A. ,   St. Petersburg Institute of History of the Russian Academy of Sciences
Published: July 2024

The article refers to one of the episodes of interaction between the Ministry of the Imperial Court and Appanages and construction contractors at the imperial residence Livadia in Crimea. The author, on the basis of materials stored in the Russian State Historical Archive, studies the process of considering the petitions of contractors, who participated in the reconstruction of the complex of the Livadia estate in 1910–1911, to receive additional payments to compensate for the losses incurred. The article notes that all submitted appeals contain a reference to force majeure circumstances that entailed unplanned expenses. The author points out that for the substantive consideration of petitions, the officials sent requests for documents to the Livadsko-Massandra Appanage administration. After receiving the materials, they made adecision based on the results of their analysis. These proceedings including the activity of the specially assigned commission could last several months or even more than a year. The study of archival documents outlined two scenarios for responding to contractors’ requests. When the case was considered exclusively by the institutions of the Department of Appanages, the applicants received part of the requested amount. At the same time, the contractors were notified of the final nature of the decision made, and further requests were rejected. According to the second scenario, when the petition reached the leaders of the Ministry of the Imperial Court and the Emperor, the Department of Appanages received the highest order to fully satisfy the contractor’s request. But even so, as the article notes, officials sought to cut costs through the use of deductions.
The Policy of the Executive Committee of the Leningrad City Council on the Restoration of Social Services for Re-evacuated Leningrad Children in the Period of the Great Patriotic War and the First Post-war Years
Authors: Amosova Alisa A. ,   St. Petersburg State University
Published: July 2024

The article examines under-researched aspect of the restoration of social services for re-evacuated Leningrad children in 1943–1946. Social services are interpreted as the work of local authorities, the Soviets, aimed at resuming the activities of children’s institutions in Leningrad, solving the problems of organizing the daily life of children outside their houses, primarily in nurseries, kindergartens, orphanages, schools, in medical institutions, and within health programs. Since February 1943, the re-evacuation of residents to Leningrad was initiated, and the city leadership was faced with the task of establishing social and consumer services for the population staying in the city. The policy related to the implementation of key restoration measures was directed by the Council of People’s Commissars of the Soviet Union and the Council of People’s Commissars of the Russian Soviet Federated Socialist Republic. The formidable challenge lay in the fact that during the war years, many city institutions were liquidated, and the buildings and premises, which had housed them, were destroyed or occupied by hospitals, headquarters of the Red Army, Red-Banner Baltic Fleet, and the People’s Commissariat for Internal Affairs. The staffing issue was acute. Topical were the issues of repair and provision of work with building materials, necessary inventory and equipment. The article is based on the clerical and regulatory documents of the Leningrad City Executive Committee from the funds of the Central State Archive of St. Petersburg; published materials of the Council of People’s Commissars of the USSR and the Council of People’s Commissars of the Russian SovietFederated Socialist Republic and the Leningrad City Executive Committee; and the data from periodicals for 1943–1946.
The Marienburg Route as an Example of Reformatting Hanseatic Communications
Authors: Bessudnova Marina B. ,   Yaroslav-the-Wise Novgorod State University
Published: July 2024

The example of the Marienburg route between Marienburg castle and Pskov enables to consider the process of reformatting the system of Hanseatic-Russian and Livonian-Russian trade communication lines in the early modern period, initiated by the leadership of the Teutonic Order in Livonia. The Livonian cities were motivated to preserve traditional traffic relations and to block unauthorized (“unusual”) routes, while the Livonian territorial lords, led by grandmaster Wolter von Plettenberg, attempted to expand their authority by including the “merchant affairs” into “land affairs”. Thanks to the Livonian-Russian agreements of the late 15th century, the Marienburg route lost its “unusual” nature and to some extent changed the Hanseatic logistics in the southeast of Livonia directing the trade not towards Dorpat but deep into the Order’s posessions and Riga. After unsuccessful attempts to move the Hanseatic office from Novgorod to Narva, Plettenberg opened the Marienburg route for Russian trade in early 1522, which bypassed the “staples” of Dorpat and Reval. The route connected the possessions of the Order with Pskov and Riga, and significantly increased its export opportunities. Dorpat and Revel tried to force the grandmaster to close the new route but failed due to the disengagement of the “foreign” Hansa, to Riga’s strikebreaking and to a new status of Plettenberg. He became Prince of the Holy Roman Empire in 1530, which allowed him to declare the roads of Livonia imperial and to claim his texceptional rights to them. This resulted in the final legalization of the Marienburg route.
Obtaining artificial analogs of Zhamanshin impact glasses by high-temperature melting
Authors: Sergienko Elena S. ,   St. Petersburg State University, Yanson Svetlana Yu. , Karpinskiy Vladimir V. , Levitskii Ivan A. , Papko Ludmila F. , Kharitonskii Petr V. ,   St. Petersburg State University,   St. Petersburg State University,   Geophysical Survey of the Russian Academy of Sciences,   Belarusian State Technological University,   Belarusian State Technological University,   St. Peterburg Electrotechnical University LETI
Published: July 2024

Establishing the genesis of coptogenic rocks and their evolution over geological time is of great importance for constructing scenarios of impact events and studying petrophysical properties of rocks in general. In spite of the fact that the Zhamanshin astrobleme (Kazakhstan) has been studied for 85 years, there are still many unsolved issues, including those in the field of modeling this impact event. Artificial analogs of impact glasses, various types of which are widespread in Zhamanshin, could reproduce the most characteristic features of natural objects in terms of their composition and morphology. By obtaining model samples from furnace charges of different composition, it is possible to project their characteristics on impactites by varying the cooling conditions that determine the processes of glass transition and crystallization. In this study, artificial analogs of impact glasses of the Zhamanshin astrobleme were obtained by melting the rocks of the astrobleme target. A gas-flame high-temperature furnace was used. The initial charge for melting was prepared in such a way as to obtain a complete melt in a sufficiently large sample volume (comparable with the volumes of some types of natural impactites of Zhamanshin — zhamanshinites and irghizites). The chemical and structural-phase composition of the artificial glasses was investigated by X-ray diffraction (XRD) and X-ray spectral fluorescence (XRF) analysis, scanning electron microscopy (SEM), and X-ray spectral microanalysis (XRMA). Differential scanning calorimetry was carried out to determine the phase transitions and chemical transformations of the source rocks under temperature changes. The chemical and structural-phase composition of the obtained glasses was compared with the characteristics of the Zhamanshin impactites and glasses of other genesis. The artificial glasses are identical to the Zhamanshin impactites. The proposed technique of obtaining analogs of impact glasses has shown its validity.
Optimized phased planning for dynamic rehabilitation of integrated municipal infrastructure
Authors: Minaei Amin , Abusamra Soliman , Hajibabaei Mohsen , Savic Dragan , Zecchin Aaron C. , Creaco Enrico , Sitzenfrei Robert
Published: July 2024

Phased planning for municipal infrastructure is based on the time-dependent status of multiple networks, which is in contrast to the traditional approach, where one-phase construction and a single status are considered for planning system activities. This study integrates and optimizes the corridor-wise intervention planning of water, sewer, and road networks where the number of equally long phases and intervention decisions are among the decision variables showing the extent to which phase number optimization can impact the cost and coordination of the interventions in interdependent systems. Optimizing the phase number for municipal infrastructure optimization within an evolutionary algorithm is a challenging task due to the evolutionary recombination between numerous planning solutions with different decision variable lengths. A multi-phase design and construction approach is developed for the rehabilitation of the system in a real case study in Montreal, Canada. The study involves 20 corridors in which a street section is co-located with water and sewer pipes. A metaheuristic single-objective optimization engine is employed to minimize the total net present value of intervention plan costs for the whole integrated system. The results show that phased optimization could bring about a 25% cost saving for the rehabilitation master plan and coordinated multi-systems intervention activities.
A novel application of waveform matching algorithm for improving monthly runoff forecasting using wavelet–ML models
Authors: Farajpanah Hiwa , Adib Arash , Lotfirad Morteza , Esmaeili-Gisavandani Hassan , Riyahi Mohammad Mehdi , Zaerpour Arash
Published: July 2024

The main goal of this study is to enhance the precision and reliability of monthly runoff forecasts within the complex Navrood watershed, situated in northern Iran. The innovative use of a waveform matching algorithm is a defining feature of this study. This approach is vital in optimizing the selection of the mother wavelet, which is a critical component in wavelet analysis. This is a significant divergence from established techniques in hydrological research, indicating a paradigm change in the area. To thoroughly assess model performance, the Technique for Order of Preference by Similarity to the Ideal Solution (TOPSIS) is applied. This all-encompassing evaluation guarantees not only astounding precision but also a near-perfect fit with the ideal solution. The findings highlight the remarkable precision attained by using the hybrid multiresolution analysis (MRA) methodology. The proposed methodology involves the integration of the maximal overlap discrete wavelet transform (MODWT) with a random forest (RF) model, referred to as MRA–RF. The obtained Nash–Sutcliffe efficiency (NSE) score of 0.94 is noteworthy. Furthermore, the model exhibits a low mean absolute error (MAE) of just 0.36 m3/s, a strong p-factor of 73.5%, and a significant d-factor of 37.9% during extensive testing.
Effectiveness of water, sanitation, hygiene, and nutritional interventions to reduce pathogenic infections and improve nutritional status in children: a systematic review and meta-analysis of randomized controlled trial
Authors: Tuba Syahrul , Pradana F. Josse Pasca , Kaizar Hafidz Ardan
Published: July 2024

Objective: This systematic review and meta-analysis aimed to assess the effectiveness of water, sanitation, hygiene (WASH), and nutritional interventions in reducing pathogenic infections and improving nutritional status in children. Method: Following PRISMA guidelines, a comprehensive search was conducted across PubMed, Cochrane, Scopus, and Epistemonikos. Only randomized controlled trials (RCTs) were included, comparing interventions related to WASH and nutritional enhancements against control groups. Meta-analysis techniques were applied to analyze the impact on weight, height, and pathogenic infections. Result: WASH interventions exhibited significant reductions in weight-related outcomes (OR: 0.58) and pathogenic infections (OR: 0.40). Height outcomes showed a positive effect (OR: 0.66). Nutritional interventions indicated significant reductions in weight-related outcomes (OR: 0.33) and positive effects on height (OR: 0.27). Although a trend towards reduced pathogenic infections was observed (OR: 0.78), statistical significance was not reached. Conclusion: WASH and nutritional interventions demonstrated meaningful impacts on weight, height, and pathogenic infections in children. These findings emphasize the importance of prioritizing such interventions for enhancing child health and well-being.
Czynniki chroniące i ryzyka wobec kryzysu w losach dzieci wojennych - trajektorie zniewolonego dzieciństwa
Authors: Bzymek Agnieszka
Published: July 2024

Artykuł ma na celu próbę ukazania możliwych analogii pomiędzy doświadczeniem dzieci syberyjskich (Theiss 1999, 2018) a obecną sytuacją dzieci z Ukrainy w czasie trwającej wojny. Odnosząc się do wybranych elementów teorii resilience (m.in. Werner, Rutter, Luthar, Cicchetti, Cyrulnik, Borucka, Ostaszewski, Junik), próbuję zlokalizować czynniki chroniące pojawiające się w losach dzieci. O ile doświadczenie tych pierwszych jest zamkniętą opowieścią, o tyle dramat obecnych dzieci obserwujemy na bieżąco. Twierdzę ponadto, że opisane trajektorie dzieci syberyjskich są przykładem zaistnienia resilience, mimo ówczesnego braku stosowania pojęcia prężności. Tym samym, fenomen resilience pojawia się w naukach o wychowaniu znacznie wcześniej niż uznaje się powszechnie. Wreszcie, odwołuję się do idei pedagogiki społecznej jako szerokiej perspektywy wsparcia dziecka w sytuacji kryzysu.
Słowa klucze: resilience, czynniki chroniące i ryzyka, dzieci wojenne, pedagogika społeczna;
The picture of the autism spectrum in television programmes for children on the example of “Sesame Street”
Authors: Łuszczek Krzysztof
Published: July 2024

Abstrakt
„Ulica Sezamkowa” jest jednym z najbardziej udanych programów edukacyjnych na świecie. Jego powstanie w 1969 r. poprzedziły szerokie konsultacje nie tylko z zakresu produkcji telewizyjnej, ale również z psychologii i pedagogiki. Powstał program, który nie tylko ma niwelować różnice w szansach edukacyjnych przedszkolaków, ale także kształtować ich postawy. Stąd w programie podejmowano również tematy takie jak zamachy z 11 września czy huragan Katrina.
W 2017 r. do programu trafiła lalka, która ma przedstawiać czteroletnią dziewczynkę z autyzmem. W założeniu twórców programu jej obecność miała pozwolić wytłumaczyć dzieciom na czym polega autyzm i wykształcić postawę szacunku wobec osób z tym zaburzeniem.
Niniejszy artykuł odpowiada na pytanie: jaki obraz spektrum autyzmu zaprezentowali twórcy „Ulicy Sezamkowej” na przykładzie Juli? Zastosowano metodę analizy zawartości przekazu telewizyjnego. Pozwoliła ona na przeanalizowanie 18 epizodów „Ulicy Sezamkowej” i jednego odcinka specjalnego.
Ich analiza pokazała, że epizody z Julią nie dają pełnego spektrum objawów autyzmu, ale akcentują te, które mogą być najłatwiej rozpoznawalne przez dzieci. Drugim ważnym elementem przekazu jest budowanie szacunku dla dzieci z autyzmem. W pewnych sytuacjach reagują inaczej, ale są godne poszanowania i nie można ich marginalizować. Epizody z Julią adresowane do dzieci w wieku przedszkolnym miały zrealizować przede wszystkim ten drugi cel co wydaje się, że zostało osiągnięte prze twórców programu.
Role of Artificial Intelligence in Pharmaceutical Drug Development
Authors: Narayan Aditya , Chanana Arsh , Shanker Oma , Kulkarni Yukta R. , Gupta Pooja , Patel Akhilesh , Havelikar Ujwal , Singh Ravindra Pal , Chawra Himmat Singh
Published: July 2024

:

One of the most popular sectors in the tech and healthcare industries right now is artificial intelligence. In the search and development of new
drugs, artificial intelligence is essential. Drug design using computer-assisted design (CADD) has supplanted the traditional approach. Artificial
intelligence is assisting businesses in the development of new drugs in a faster, more affordable, and more efficient manner, saving money and
manpower in the process of creating new drug molecules to treat any disease. Quantitative structure-activity relationship (QSAR) analysis, activity
scoring, in silico testing, biomarker development, and mode of action identification are all aided by artificial intelligence. It is revolutionizing these
sectors by swiftly identifying potential drug candidates, efficiently conducting clinical trials, and customizing patient care. AI optimizes drug
manufacturing processes, augments safety monitoring, and streamlines market analysis. In clinical trials, AI streamlines patient recruitment and
ensures more precise trial designs, leading to faster and more efficient research. AI empowers personalized medicine by tailoring treatment plans
and drug dosages to individual patient characteristics. AI also optimizes pharmaceutical manufacturing processes, amplifies safety monitoring by
analyzing real-time data for adverse events, and supports market analysis and sales strategies. AI in the pharmaceutical industry is a multifaceted
tool. Artificial Intelligence (AI) has the potential to streamline complex pharmaceutical regulatory matters. Regulatory processes like audits and
dossier completion can be automated with AI tools.
Influence of Psychological Stress on the Response to Periodontal Treatment: Protocol for a Systematic Review
Authors: Vargas Villafuerte Kelly R , Palucci Vieira Luiz H , Oliveira Santos Karina
Published: July 2024

Background

The interaction between stress and periodontal treatment is a topic of growing interest. It stands out as a field of research that sheds light on the complexity of oral health in individuals subjected to high levels of emotional stress.

Objective

This paper aims to provide a protocol for a systematic review to examine the scientific evidence related to the influence of psychological stress on the response to periodontal treatment.

Methods

The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines will be followed, and the study is based on a formulation of PECO (Participants, Exposure, Comparators, and Outcomes) questions. This systematic review will involve a literature search covering studies published from January 2000 to May 2024. It will include searching the PubMed, Web of Science, EBSCOHost, Scopus, and ProQuest databases to identify relevant studies. After selection, data extraction and quality assessment (using the Ottawa-Newcastle Scale) of the included studies will be carried out. The objective is to integrate high-quality evidence on how psychological stress impacts the outcomes of periodontal treatment. Depending on the number and methodological consistency of included studies, the results may be presented by meta-analysis or qualitative synthesis.

Results

The current stage of the study consists of selecting studies for the systematic review as outlined by this protocol. The search, screening, and data extraction began in January 2024. The final results are expected by July 2024, with final manuscript submission planned for November 2024.

Conclusions

This review will help clarify how psychological factors, such as stress, influence the results of periodontal treatment, providing valuable guidelines for future research and helping clinicians make decisions about the best treatment options for patients.

Trial Registration

Open Science Framework (OSF) Registries qfs6p; https://osf.io/qfs6p

International Registered Report Identifier (IRRID)

PRR1-10.2196/56765
THE EFFECTIVENESS OF MUCOADHESIVE AND MOUTHWASH THERAPY FOR ORAL MUCOSITIS WITH SYNTHETIC AND HERBAL INGREDIENTS: A SYSTEMATIC REVIEW AND META-ANALYSIS
Authors: KARINA DHINI , SUFIAWATI IRNA , RAMAMOORTHY VATCHALA RANI
Published: July 2024

This study aimed to evaluate the effectiveness of herbal and synthetic mucoadhesive formulations and mouthwashes to reduce the grade and pain of Oral Mucositis (OM) through a systematic review and meta-analysis. Selection of articles published between 2014 and 2023 using Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) with specific keywords and through electronic databases (PubMed, Cochrane, Scopus, and Google Scholar) was carried out. Inclusion and exclusion criteria were established to limit the search for articles. The quality assessment of the articles used the Oxford Quality Scoring System. All 22 articles could be assessed by systematic review, but only 16 articles could be meta-analysis. The meta-analysis assessment used Jeffreys's Amazing Statistics Program (JASP) software. The mucoadhesive formulations of 1% Satureja hortensis extract gel, phenytoin tablets, 3% Chamomile topical gel and the mouthwash consisting morphine 2%, povidone-iodine 10 ml, turmeric, dentoxol, zinc chloride, sodium bicarbonate had affected to reduce the degree and pain of OM. Meta-analysis showed mucoadhesive had a mean effect size of -0.06 on the grade and -0.12 on the pain of the OM, while mouthwash had a mean effect size of -1.27 on the grade and -1.64 on the pain of the OM. To conclude, mucoadhesive formulations and mouthwashes have the potential to reduce the grade and pain of OM.
IDENTIFICATION OF BENZYLIDENE AMINO PHENOL INHIBITORS TARGETING THYMIDYLATE KINASE FOR COLON CANCER TREATMENT THROUGH IN SILICO STUDIES
Authors: BAQI MOHD ABDUL , JAYANTHI KOPPULA , R. RAJESH KUMAR
Published: July 2024

Objective: Thymidylate kinase (TMK) is pivotal in bacterial DNA synthesis, facilitating the conversion of Deoxythymidine Monophosphate (dTMP) into Deoxythymidine Diphosphate (dTDP). This crucial role positions TMK as an attractive target for the creation of innovative anti-cancer therapies. To date, there have been no anti-cancer medications developed specifically targeting this enzyme.
Methods: The investigation involved screening benzylidene derivatives as potential ligands for their efficacy. This process was executed through the utilization of the Glide module for molecular docking, followed by an Absorption, Distribution, Metabolism, and Excretion (ADME) analysis via Qikprop. Subsequently, the Prime Molecular Mechanics-Generalized Born Surface Area (MM-GBSA) approach was employed to evaluate the binding free energy of these ligands. To further assess the stability of these ligands as inhibitors of Human Thymidylate Kinase (HaTMK), molecular dynamics (MD) simulations were conducted over a 100 nanosecond timeframe.
Results: Among the screened molecules, ten exhibited significant binding affinity, engaging in hydrogen and hydrophobic interactions with the Asp15, Phe105, and Phe72 residues of the HaTMK enzyme (PDB ID: 1E2D). Notably, the molecule 4-((4-dichlorobenzylidene) amino) phenol demonstrated the highest docking score with an Extra Precision (XP)-docking value of −6.33 kcal/mol, indicating a strong binding affinity based on extra-precision docking. Further analysis through Prime MM-GBSA revealed notable binding energies, including a ΔGBind of −52.98 kcal/mol, ΔGLipo of −27.75 kcal/mol, and ΔGVdW of −47.70kcal/mol, suggesting significant interaction strength. Throughout the MD simulations, interactions between the ligand and the Glu152 and Phe105 residues remained stable, underlining the molecule's potential as a TMK inhibitor.
Conclusion: The ligand 4-((4-dichlorobenzylidene) amino)phenol, characterized by its benzene ring, benzylidene moiety, and oxygen group, engages effectively with the HaTMK protein's active sites. This interaction showcases its promising potential as an inhibitor of HaTMK, positioning it as a viable candidate for the treatment of colon cancer.
DEVELOPMENT AND OPTIMIZATION OF COATED TABLET CONTAINING AMLODIPINE AND VALSARTAN FOR HYPERTENSION TREATMENT
Authors: HUYNH DUYEN THI MY , VINH TRUONG PHU , TAM TRAN DUNG , T. LE MINH-NGOC , NGUYEN PHUOC-VINH
Published: July 2024

Objective: To develop and optimize the formulation of coated tablets containing these Active Pharmaceutical Ingredients (APIs) with in vitro equivalence to that of the original drug.
Methods: Design Expert and BCPharSoft OPT softwares were applied in the development and optimization of film-coated tablets of amlodipine 5 mg and valsartan 80 mg, in order to obtain a tablet formulation with in vitro equivalence to the original drug in three dissolution testing environments. Evaluating through appearance, identification, medium hardness, weight uniformity, in vitro equivalence, assay.
Results: An optimized formulation of film-coated tablets with in vitro equivalence to the referent drug was obtained. For the tablet core, it is composed of amlodipine besylate 6.94 mg (equivalent to 5 mg amlodipine) and valsartan 80 mg with excipients of 9.77% crospovidone XL, 2% aerosil, 2.75% magnesium stearate, 42.01% avicel PH 112, with a hardness of 70-90 N. The film-coating suspension comprises 4.75% Hydroxypropyl Methylcellulose 6cps (HPMC 6cps), 0.42% polyethylene glycol 6000 (PEG 6000), 0.84% talc, 1.77% titanium dioxide (TiO2), 0.12% yellow iron oxide, in 92.1% ethanol 96%-water (2:1).
Conclusion: In the current study, a film-coated tablet formulation with in vitro equivalence of two APIs to the original drug in all three environments was successfully developed and optimized. The obtained results are an important premise for the development of related generic drugs in the pharmaceutical market of developing countries, which not only reduces the product price but also help less wealthy patients in developing countries to better control hypertension disease.
SCIENTIFIC EVIDENCE FOR STABILITY EVALUATION AND SHELF-LIFE ESTIMATION OF VACHA CHURNA BY USING RP-HPLC
Authors: NIHARIKA G. , MD ISHA ALI SYEDA ALISHA , BHAT KRISHNAMURTHY , HADAPAD BASAVARAJ S. , MUDDUKRISHNA B. S. , RAVI GUNDAWAR , BALLAL MURALIDHAR , VASANTHARAJU S. G.
Published: July 2024

Objective: The concept of shelf life of classical Ayurvedic formulations is clearly defined in the classical literature of Ayurveda. Considering the Ayurveda development and recent gazette notification of 161-B, it is important to evaluate the stability of the Ayurvedic products based on scientific evidence. The study aims to evaluate the stability and estimate the shelf life of Vacha churna by using the marker Beta-asarone. The chemical marker of the Vacha churna has been identified as Beta-asarone.
Methods: A stability-indicating RP-HPLC method has been developed and validated for Beta-asarone. The method utilises a Stationary phase C18 column and a mobile phase composed of acetonitrile and ammonium acetate buffer. Beta-asarone underwent various stress conditions like acid and base hydrolysis, oxidation, temperature and photolytic degradation. The Vacha churna has been stored in a stability chamber for both accelerated and long-term testing. The formulation was taken at specific time intervals and the marker content was analysed using RP-HPLC.
Results: Beta-asarone was eluted at 6.03 min. The linear regression equation was found to be y = 28211x-1349.3 with a R2 of 0.9991. Stress studies confirmed the absence of co-eluting peaks and degradants under various stress conditions. Based on the analysis of Beta-asarone marker content, the shelf life of Vacha churna was estimated to be 62.40 mo.
Conclusion: Data from RP-HPLC method and stability studies can be employed for routine commercial stability assessments. Due to the absence of a Pharmacopoeial RP-HPLC method, local Ayurvedic manufacturers can utilise the developed method. The investigated shelf life thus serves as a medium of chemical stability based on the scientific evidence.
At Home: Where I am is Here
Authors: Ewing Suzanne , Brooks Andrew
Published: July 2024

Degree Show Catalogue documenting an ESALA MArch (Modular Pathway) studio ‘At Home: Where I am is Here’. Studio Leaders: Suzanne Ewing and Andrew Brooks. 2020-2021.
Fixed point and stability of nonlinear differential equations with variable delays
Authors: Younsi Abdelhafid
Published: July 2024

In this paper, we study the stability of a generalized nonlinear differential equation with variable delays via fixed point theory. An asymptotic stability theorem with sufficient conditions is proved, which improves and generalizes some previous results. Two examples are given to illustrate our results.
Evaluación psicopedagógica de los roles y las experiencias docentes en las prácticas educativas inclusivas colombianas
Authors: Buitrago Bejarano Diana Carolina
Published: July 2024

Este estudio analiza las experiencias de 17 docentes colombianos de educación primaria en la atención a estudiantes con discapacidad, registradas en 17 instituciones educativas de 11 municipios entre 2018 y 2022. Mediante un diseño narrativo y un cuestionario de preguntas abiertas, se exploraron las interacciones de estos docentes con el entorno educativo. Se identificaron 12 factores psicológicos y 13 pedagógicos y se examinó su impacto en función de los tipos de discapacidad y las características específicas de los estudiantes y contextos educativos. Los resultados revelan una alta variabilidad y subjetividad en estos factores, los cuales pueden ser tanto favorecedores como obstaculizadores de las prácticas educativas inclusivas. Adicionalmente, el estudio examina el Plan Individual de Ajustes Razonables, destacando deficiencias significativas en su implementación y resistencia por parte de algunos sectores escolares, lo cual subraya desafíos en la adopción del modelo de educación inclusiva promovido por el Estado colombiano. Este análisis proporciona insights valiosos para la mejora continua de las prácticas inclusivas en el sistema educativo colombiano.
Implementasi Kurikulum Full Day School Dalam Membentuk Karakter Siswa di MI Plus Al-Azhar Kabupaten Blitar
Authors: Rohmatun Nur , Marno Marno
Published: July 2024

Penelitian ini dilakukan karena peneliti menemukan permasalahan yang terjadi dalam implementasi kurikulum full day school di MI Plus Al-Azhar Blitar dimana karakter siswa masih rendah. Peneliti tertarik untuk melihat penerapan kurikulum full day school, mendeskripsikan permasalahan atau kendala yang terjadi dan menawarkan solusinya. Jenis penelitian ini menggunakan metodologi kualitatif dan dilakukan di lapangan. Data dikumpulkan melalui observasi, wawancara, dan dokumentasi. Hasil penelitian sebagai berikut: 1) Implementasi kurikulum full day school dalam membentuk karakter siswa di MI Plus Al-Azhar Blitar diimplementasikan dengan beberapa cara yaitu pembiasaan sholat berjamaah, Kultum setelah sholat dzuhur berjamaah , program tahfid dan usmani termasuk dalam pelajaran sekolah, pemberian amanat dari guru kepada siswa di akhir jam sekolah, kontrol oleh kepala sekolah, dan adanya kegiatan ekstrakurikuler; (2) Permasalahan yang terjadi dalam penerapan kurikulum full day school dalam membentuk karakter siswa di MI Plus Al-Azhar Blitar adalah kurangnya adab siswa khususnya kelas 6 yaitu tidak menghormati guru dan suka berbicara kotor. . Penyebab permasalahan tersebut dipengaruhi oleh faktor internal dan eksternal; (3) Solusi dari permasalahan yang terjadi dalam implementasi kurikulum full day school dalam membentuk karakter siswa di MI Plus Al-Azhar Blitar adalah keteladanan guru, penanaman akhlak, pemberian nasehat oleh guru, penekanan pada masa awal jam, dan tindak lanjut dari konselor bimbingan di sekolah.
Urgensi Pendidikan Akhlak Perpsektif Psikologi Islam pada Anak Usia Dini
Authors: Khairunnisa Indah
Published: July 2024

Latar belakang penelitian ini adalah pentingnya penguatan pendidikan akhlak pada anak usia dini. Mengingat bahwa anak usia dini merupakan anak yang berada pada periode golden age, maka pendidikan akhlak yang berikan menjadi dasar dalam perkembangan akhlak anak. Penelitian ini bertujuan untuk menganalisis peran dan metode pendidikan akhlak pada anak usia dini sesuai perspektif psikologi Islam. Metode penelitian ini menggunakan studi kepustakaan, yang mana data-data penelitian didapatkan dari sumber literatur-literatur pustaka. Hasil dalam penelitian ini menunjukkan bahwa terdapat beberapa metode pendidikan akhlak yang sesuai dengan perkenbangan anak usia dini menurut psikologi Islam yaitu metode keteladanan, bermain dan bercerita, reward dan punishment, serta pembiasaan.
Assessing The Safety of Laparoscopic Surgery in Treating of Adenocarcinoma Endometrial Cancer
Authors: Kumari Dr Kumud , Jha Dr Nidhi , S Dr Narendranat , Abraham Dr John , Vasudevan Dr. Ramesh , C Srilakshmi
Published: July 2024

In recent years, there has been a growing preference for laparoscopic surgery. Insufficient data exists on the safety of laparoscopy in endometrial cancer. The objective of this study was to assess and compare the perioperative and oncologic results of laparoscopic and laparotomic. staging surgery in patients diagnosed with adenocarcinoma endometrial cancer. The study aimed to evaluate the safety and effectiveness of laparoscopic surgery in this specific patient group. A retrospective analysis was conducted on the data of 250 patients who had surgical staging for adenocarcinoma endometrial cancer at the gynecologic oncology department of a government hospital from 2018 to 2023. A comparison was made between the laparoscopy and laparotomy groups in terms of demographic, histopathologic, perioperative, and oncologic parameters. An additional assessment was conducted on a subset of individuals who had a body mass index greater than 30. The demographic and histopathologic parameters of the two groups were comparable, however laparoscopic surgery demonstrated a much higher level of effectiveness in terms of perioperative outcomes. The laparotomy group had a much greater number of excised and metastatic lymph nodes. However, this difference did not have an impact on the oncologic outcomes, such as recurrence and survival rates. Both groups had similar results in this regard. The results of the subgroup with a BMI more than 30 were consistent with those of the entire population. The intraoperative problems encountered during the laparoscopic procedure were effectively resolved. Laparoscopic surgery is considered superior to laparotomy and, depending on the surgeon's expertise, it can be safely used for surgical staging of adenocarcinoma endometrial cancer.
A COMPREHENSIVE MODEL OF MANAGEMENT CULTURE UNDER CONDITIONS OF UNCERTAINTY
Authors:   Financial University under the Government of the Russian Federation, PROKAZINA N.V.
Published: July 2024

Uncertainty and the unknown as integral attributes of modernity leave their mark on the development of all processes and phenomena. They also have a significant impact on management cycles, creating new demands and challenges. The purpose of the article is to substantiate a conceptual approach to the study of management culture, identifying its structural, functional and substantive characteristics, and developing a comprehensive model of management culture under conditions of uncertainty. The author substantiates an original comprehensive model that includes structural, functional and content components of management culture and its key principles. The methodological basis consists of the works by A.V. Tikhonov, D.G. Peredni and the author’s development of the problem. The empirical basis for the formulated conclusions and provisions were the results of all-Russian studies of 2017–2023, the results of an expert discussion of 2023 and the conclusions of an international study of 2023 on leadership issues in modern conditions. As a result, the author argues for the conclusion that in conditions of permanent, global and rapid changes, constant correction of the substantive and value-semantic components of management culture is required. The proposed comprehensive model can become a conceptual basis for further research into management culture and identifying key directions for its development.
AN EFFECTIVE MODEL OF INTERACTION BETWEEN THE STATE AND CIVIL SOCIETY IN RUSSIAN REGIONS: CRITERIA AND ASSESSMENT MECHANISMS
Authors:   Federal Center of Theoretical and Applied Sociology of the Russian Academy of Sciences, ILYICHEVA L.E. , KHMELEV V.A. ,   Russian Presidential Academy of National Economy and Public Administration
Published: July 2024

The scientific article presents and substantiates the optimal mechanisms, procedural and substantive aspects of the formation of the socio-political agenda of the Russian region, which is a product of interaction (interactionism) between government bodies and business structures. An extremely detailed description of these aspects is relevant in scientific discourse and applied political and managerial practices, since it allows us to improve the efficiency of interaction between government and business in preparing and making management decisions. The purpose of the article is to present and justify the author’s model of optimal interaction between the state and civil society institutions according to the proposed performance indicators in the formation and implementation of the socio-political agenda in the constituent entities of the Russian Federation, to outline ways to improve such interaction, taking into account regional characteristics. The object of the study is the interactionism of the state and civil society institutions in the formation of the socio-political agenda in the constituent entities of the Russian Federation. The subject of the study is the essential characteristics, mechanisms and forms of interaction between the state and civil society institutions in the processes of forming the socio-political agenda in the constituent entities of the Russian Federation, directions for improving this interaction.
Russian Law-Making (on the Example of the Federal Executive Authority): Ethical Aspect
Authors: Litovko K. S.
Published: July 2024

The purpose of the work was to analyze the modern process of law-making in Russia on the example of the federal executive authority, taking into account ethical aspects. To achieve this goal, general philosophical methods and the formal legal method were used. The paper presented current theoretical views on law-making, as well as described the procedure of law-making in the federal executive authority. Ethical contradictions and problems existing in this procedure were considered. The general trends in the development of the law-making process in Russia were also indicated and conclusions were drawn about the need to take into account ethical approaches when improving the law-making procedure.
Seleksi Aktinomisetes dalam Menghasilkan Indole Acetic Acid dan Efektivitas Terhadap Perkecambahan Benih Cabai Merah (Capsicum annum L.)
Authors: Anggraini Yeyen Septia , Linda Tetty Marta , Lestari Wahyu
Published: July 2024

Indole Acetic Acid (IAA) berperan penting dalam memacu pertumbuhan tanaman. Aktinomisetes merupakan salah satu kelompok bakteri yang mampu menghasilkan IAA. Penelitian ini bertujuan untuk menyeleksi aktinomisetes dari tanah gambut Siak, Riau dalam menghasilkan IAA dan pengaruhnya terhadap perkecambahan tanaman cabai merah (Capsicum annum L.). Hasil penelitian menunjukkan 21 isolat aktinomisetes hanya mampu menghasilkan IAA pada medium Starch Casein Broth (SCB) diperkaya triptofan. Produksi IAA tertinggi dihasilkan oleh isolat L225 dengan konsentrasi 37,70 Â± 1,00 Âµg/ml pada medium SCB diperkaya triptofan. Ada 14 isolat aktinomisetes memberikan respons terhadap panjang kecambah dan 20 isolat memberikan pengaruh terhadap panjang akar pada benih cabai merah dengan inkubasi selama 15 hari.
Uji Efektivitas Daun Kelor Terhadap Shigella Dysenteriae
Authors: Karo Mellinia Alpatri Br , Ferdinanda Fransiska , Natali Oliviti , Nasution Sri Wahyun
Published: July 2024

Penyakit diare merupakan salah satu penyakit yang masih sering terjadi di negara berkembang dan salah satu faktor penyebab terjadinya diare adalah bakteri Shigella dysenteriae. Daun kelor (Moringa oleifera Lamk) terdapat senyawa alkaloid, tanin, saponin, flavonoid, triterpen/ steroid, dan polifenol yang dilaporkan memiliki aktivitas antimikroba dan antioksidan yang tinggi. Penelitian ini bertujuan untuk mengetahui efektivitas dari ekstrak daun kelor (Moringa oleifera Lamk) dalam menghambat pertumbuhan bakteri Shigella dysentriae. Penelitian ini menggunakan rancangan penelitian Post-Test Only Control Group Design dan menggunakan metode disc diffusion dimana ekstrak diletakkan pada media MHA yang telah diinokulasi dengan bakteri Shigella dysentriae. Data yang diambil merupakan data primer yang diperoleh dengan mengamati zona hambat yang terbentuk pada konsentrasi 15%, 30%, 45%, 60%, 75%. Dari hasil pengujian yang telah dilakukan menunjukkan bahwa daun kelor (Moringa oleifera Lamk) mampu menghambat bakteri pada konsentrasi 75% dengan rata-rata zona hambat 91.1 mm.
Studi Keanekaragaman Drosophila Sp. di Kota Jambi
Authors: Siburian Jodion
Published: July 2024

Telah dilakukan penelitian yang bertujuan untuk mengidentifikasi keanekaragaman spesies Drosophila hasil tangkapan di Kota Jambi. Penangkapan Drosophila dilakukan dengan sistem perangkap menggunakan umpanmedium pemeliharaan TGPR (Tepung-Gula-Pisang-Ragi). Penelitian bertujuan untuk mengetahui keanekaragamanspesies Drosophila yang terdapat di Kota Jambi. Sampel diambil dengan cara purposive sampling dan data dianalisissecara deskriptif. Determinasi dan identifikasi dilakukan dilaboratorium FKIP, UPMIPA dan Laboratrium BioteknologiUniversitas Jambi pada bulan September - Desember 2007. Dari 8 Kecamatan di Kota Jambi, keanekaragamanspesies Drosophila yang diperoleh adalah termasuk Sub Genus Sophophora, jenis Drosophila ananassae, Drosophilabipectinata, Drosophila pallidosa, dan Drosophila melanogaster.
Effect of Type and Arbuskular Mikoriza Mushroom Dosage (CMA) to Growth of Chili [Capsicum annuum L.] at Ultisol Soil
Authors: Harlis Harlis , Murni Pinta , Fitria Ayu Billy
Published: July 2024

The research has objective to know the effect of type and arbuskular mikoriza mushroom doses (CMA)to growth of chili (Capsicum annuum L.) at ultisol soil. This research used Completely Randomize Design of Factorialpattern consisting of two factor, that is : first factor of mikoriza type which consist of 3 level, j1 = Glomus sp., j2 =Gigaspora sp. and j3 = Glomus sp. and Gigaspora sp., than second factor of mikoriza doses which consist of 4level, d0 = 0 g, d1 = 5 g, d2 = 10 g. and d3 = 15 g. Data analyzed to use ANOVA and test continued DNMRT at 5% reallevel. The result showed that arbiskular mikoriza doses and type was significantly different to high plant, biomass growon and content of P. Type Gigaspora sp. with dose 15 g can be improve P element absorption and optimal growthvegetative.
Studi Etnobotani Jernang (Daemonorops spp.) pada Masyarakat Desa Lamban Sigatal dan Sepintun Kecamatan Pauh Kabupaten Sarolangun Jambi
Authors: Yetty Yetty , Hariyadi Bambang , Murni Pinta
Published: July 2024

Tetapi, sejumlah faktor mengancam populasi alami jernang seperti aktivitas illegal loging yang menghilangkan pepohonan kayu sebagai media tegakkan jernang serta kerusakan habitat alami jernang.Â  Penelitian ini bertujuan untuk mengetahui aspek etnobotani jernang termasuk upaya pembudidayaanya.Â  Pengumpulan data dilakukan melalui observasi partisipatif, wawancara pembuatan herbarium dan identifikasi tumbuhan. Hasil penelitian menunjukkan adanya lima species jerang di kedua desa yang diamati.Di Desa Lamban Sigatal terdapat tiga jenis yaitu Daemonorops draconcella Becc., Daemonorops aff.Daemonorops propinqua Becc., Daemonorops draco Blume sedangkan di Desa Sepintun terdapat empat jenis yaitu Daemonorops aff.Daemonorops maculata J.Dransf., Daemonorops draconcella Becc., Daemonorops draco Blume dan Daemonorops propinqua Becc. Getah jernang dimanfaatkan sebagai obat luka, obat sakit gigi, obat sehabis melahirkan, dan pewarna cat. Proses pengolahan jernang yang dilakukan melalui dua tahap yaitu proses pengolahan secara kering dan proses pengolahan secara basah. Upaya pembudidayaan umumnya dilakukan dengan cara menerapkan pola tumpang sari jernang dengan tanaman karet
Pengaruh Hormon Giberelin (GA3) Terhadap Daya Kecambah dan Vigoritas Calopogonium caeruleum
Authors: Asra Revis
Published: July 2024

Penelitian ini bertujuan untuk mengetahui pengaruh hormon giberelin (GA3) terhadapdaya kecambah dan vigoritas Calopogonium caeruleum. Penelitian menggunakan RancanganAcak Lengkap (RAL) dengan dua faktor. Faktor pertama konsentrasi GA3 (G) terdiri dari 6 tarafG0 = 0 ppm, G1 = 100 ppm, G2 = 200 ppm, G3 = 300 ppm, G4 = 400 ppm, G5 = 500 ppm,sedangkan faktor ke dua adalah lama perendaman, terdiri dari 3 taraf yaitu T1 = 6 jam, T2 = 12jam dan T3 = 24 jam, sehingga didapat 18 kombinasi perlakuan dengan ulangan sebanyak 3kali. Parameter yang diamati meliputi persentase daya kecambah (%) dan vigoritas (%). Analisisdata menggunakan analisis sidik ragam (ANOVA) dan apabila terdapat perbedaan nyatadilanjutkan dengan uji lanjut Duncan pada taraf 5%. Hasil penelitian menunjukkan bahwainteraksi konsentrasi GA3 dan lama perendaman memperlihatkan pengaruh yang nyata(P<0,05) terhadap persentase perkecambahan dan vigoritas Calopogonium caeruleum.Perlakuan yang terbaik dalam menghasilkan persentase perkecambahan Calopogoniumcaeruleum tertinggi adalah G5T3 (GA3 500 ppm dengan lama perendaman 24 jam) yaitusebesar 57,33%.
Pengaruh Penambahan Beberapa Cairan Rumen Terhadap Produksi Biogas dari Kotoran Sapi
Authors: Ningsih Sri Suciati , Ahda Yuni , Handayani Dezi
Published: July 2024

Pengembangan teknologi bahan bakar alternatif perlu dilakukan untuk mengurangi ketergantungan masyarakat terhadap bahan bakar fosil. Salah satu teknologi bahan bakar alternatif yang memiliki prospek baik untuk dikembangkan adalah biogas. Penambahan biostarter dapat memaksimalkan produksi biogas. Cairan rumen dapat dijadikan sebagai biostarter yang baik karena di dalamnya terdapat bakteri selulolitik dan metanogenik. Penelitian ini mengenai pengaruh penambahan beberapa cairan rumen terhadap produksi biogas dari kotoran sapi. Penelitian dilakukan di Laboratorium Bioteknologi Universitas Negeri Padang. Metode yang digunakan adalah eksperimen yang disusun dalam Rancangan Acak Lengkap (RAL) dengan empat perlakuan dan tiga ulangan. Perlakuan menggunakan cairan rumen sapi (P1), kerbau (P2), kambing (P3), dan tanpa penambahan cairan rumen (P0). Fermentor berisi substrat dengan perbandingan kotoran sapi:air:cairan rumen adalah 1:1:1 difermentasi selama 7 hari. Variabel yang diukur adalah volume balon penampung biogas (cm3) dan lama nyala biogas (dt). Berdasarkan hasil uji ANOVA (P<0,05) dan uji lanjut DNMRT diketahui bahwa penambahan cairan rumen berpengaruh signifikan terhadap produksi biogas dari kotoran sapi. Penambahan cairan rumen sapi, kerbau, dan kambing pada fermentor yang difermentasi selama 7 hari dapat meningkatkan volume biogas dibandingkan tanpa penambahan cairan rumen. Rerata volume maksimal biogas P1 sebanyak 71,97 cm3, P2 sebanyak 80,26 cm3 sedangkan P0 sebanyak 2,88 cm3. Volume biogas tertinggi diperoleh dari penambahan cairan rumen kambing dengan rerata volume 102,7 cm3 pada hari ke-4.