bluuebunny/crossref_metadata_2025 huggingface dataset:
From Homo Economicus – to Homo Sapiens
Authors:   Sergey Yu. Witte Institute for New Industrial Development, Bodrunov Sergey D.
Published: January 2022

The challenges and global problems facing humanity urgently need to be ad­dressed. Will new technologies become a means of exacerbating these problems and will they have a destructive impact on the nature of man himself? There is such a risk. However, new technological advances simultaneously open up op­portunities for solving these problems. The transition to a new industrial society of second-generation based on the growth of knowledge-intensive production makes it possible to expand the satisfaction of human needs while reducing the burden on the natural environment. But for this to happen, there must be a shift in people’s motivation, a shift away from the pursuit of material goods driven by economic rationality and the satisfaction of false needs inflated by the market, and a transition to a non – economic mode of production – noonomy. This shift is possible, of course, not on the basis of “persuasion” or compulsion to asceti­cism, but on the basis of objective changes in the conditions of human existence: his exit from direct material production, his transition to creative activity, the ex­pansion (on the material basis of the production system of the next generation) of opportunities to meet his reasonable needs. People themselves will set limits to their needs, focusing them not on the absorption of the greatest possible amount of goods, but on the conditions of their self-realization. It is on this path that it is possible to solve the urgent problems of development – both of civiliza­tion and of human personality – and to mitigate social conflicts on the basis of objectively increasing socialization of society and on the ideological platform of solidarity, and, in the future, to eliminate their causes.
Determination of the Near-Wellbore Pressure Drop for Dual Casing in Hydraulic Fracturing and Refracturing Applications
Authors: Loehken Joern , Yosefnejad Davood , McNelis Liam , Fricke Bernd
Published: January 2022

Due to the increases in completion costs demand for production improvements, fracturing through double casing in upper reservoirs for mature wells and refracturing early stimulated wells to change the completion design, has become more and more popular. One of the most common technologies used to re-stimulate previously fracked wells, is to run a second, smaller casing or tubular inside of the existing and already perforated pipes of the completed well. The new inner and old outer casing are isolated from each other by a cement layer, which prevents any hydraulic communication between the pre-existing and new perforations, as well as between adjacent new perforations.

For these smaller inner casing diameters, specially tailored and designed re-fracturing perforation systems are deployed, which can shoot casing entrance holes of very similar size through both casings, nearly independent of the phasing and still capable of creating tunnels reaching beyond the cement layer into the natural rock formation.

Although discussing on the API RP-19B section VII test format has recently been initiated and many companies have started to test multiple casing scenarios and charge performance, not much is known about the complex flow through two radially aligned holes in dual casings.

In the paper we will look in detail at the parameters which influence the flow, especially the Coefficient of Discharge of such a dual casing setup. We will evaluate how much the near wellbore pressure drop is affected by the hole's sizes in the first and second casing, respectively the difference between them and investigate how the cement layer is influenced by turbulences, which might build up in the annulus.

The results will enhance the design and provide a better understanding of fracturing or refracturing through double casings for hydraulic fracturing specialists and both operation and services companies.
Supervised Learning Predictive Models for Automated Fracturing Treatment Design: A Workflow Based on Algorithm Comparison and Multiphysics Model Validation
Authors: Khan Abdul Muqtadir , BinZiad Abdullah , Al Subaii Abdullah , Alqarni Turki , Jelassi Mohamed Yassine , Najmi Asim
Published: January 2022

Diagnostic pumping techniques are used routinely in proppant fracturing design. The pumping process can be time consuming; however, it yields technical confidence in treatment and productivity optimization. Recent developments in data analytics and machine learning can aid in shortening operational workflows and enhance project economics. Supervised learning was applied to an existing database to streamline the process and affect the design framework.

Five classification algorithms were used for this study. The database was constructed through heterogeneous reservoir plays from the injection/falloff outputs. The algorithms used were support vector machine, decision tree, random forest, multinomial, and XGBoost. The number of classes was sensitized to establish a balance between model accuracy and prediction granularity. Fifteen cases were developed for a comprehensive comparison. A complete machine learning framework was constructed to work through each case set along with hyperparameter tuning to maximize accuracy. After the model was finalized, an extensive field validation workflow was deployed.

The target outputs selected for the model were crosslinked fluid efficiency, total proppant mass, and maximum proppant concentration. The unsupervised clustering technique with t-SNE algorithm that was used first lacked accuracy. Supervised classification models showed better predictions. Cross-validation techniques showed an increasing trend of prediction accuracy. Feature selection was done using one-variable-at-a-time (OVAT) and a simple feature correlation study. Because the number of features and the dataset size were small, no features were eliminated from the final model building. Accuracy and F1 score calculations were used from the confusion matrix for evaluation, XGBoost showed excellent results with an accuracy of 74 to 95% for the output parameters. Fluid efficiency was categorized into three classes and yielded an accuracy of 96%. Proppant concentration and proppant mass predictions showed 77% and 86% accuracy, respectively, for the six-class case. The combination of high accuracy and fine granularity confirmed the potential application of machine learning models. The ratio of training to testing (holdout) across all cases ranged from 80:20 to 70:30. Model validations were done through an inverse problem of predicting and matching the fracture geometry and treatment pressures from the machine learning model design and the actual net pressure match. The simulations were conducted using advanced multiphysics simulations.

The advantages of this innovative design approach showed four areas of improvement: reduction in polymer consumption by 30%, reduction of the flowback time by 25%, reduction of water usage by 30%, and enhanced operational efficiency by 60 to 65%.
A crosscorrelation methodology for in vivo pharmacokinetic study by the trans-scale fluorescent system
Authors: Gu Yueqing , Li Siwen , Lin Qiao , Ma Yi , Qian Lu , Wang Lijun , Wang Xin , Wang Feilong , Zhao Yixin , He Hua , Zhou Fang , Peng Ying , Liu Liwei , Qu Junle , Wang Zhaohui
Published: January 2022

Conventional single-organ-isolation-based pharmacokinetics study is short of time-course information and exists considerable inaccuracy due to the inter-individual differences and characteristic imparities between in vivo and ex vivo tissues/cells. The in vivo time-course and multi-organs study of model drugs in living subjects could afford precise spatio-temporal correlation. Herein, a revolutionized trans-dimensional fluorescence system was home built, with the macro-level detection part for simultaneous pharmacokinetic study in different organs, and one confocal imaging needle for micro-level visualizing cellular uptake of drugs with super-high resolution (0.472 μm). Correlating these simultaneous acquired trans-scale data, an innovative physiologically-based pharmacokinetics (PBPK) model was firstly created for predicting drug disposition in other species. Its accuracy and reliability was firmly supported by the high consistent predicted-data with the real-measured data in mice and in human, respectively. This study provides an innovative methodology and revolutionized instrument for in vivo real-time advancing assessment of druggability.
Parenting Experiences of Cancer Patients with Minor Children and Their Conversations About the Possibility of Death: A Cross-Sectional Web-Based Survey for an Online Cancer Community
Authors: Usui Yuko , Kosugi Kazuhiro , Nishiguchi Yohei , Miura Tomofumi , Fujisawa Daisuke , Uehara Yuko , Kawaguchi Takashi , Izumi Kayo , Takehana Jun , Matsumoto Yoshihisa
Published: January 2022

Purpose
Many cancer patients with minor children experience difficulty when talking about their illness with their children. The aim of this study is to investigate the parenting experiences of cancer patients with minor children and their conversations about the possibility of death.
Methods
A cross-sectional web-based survey was conducted between April and May 2019. Cancer patients with minor children were recruited from among an online peer support group called “Cancer Parents”. The participants were asked to complete a questionnaire about their experiences talking about their illness with their children. The participants were classified into those who disclosed their cancer to their children (“disclosed group”), and those who didn’t disclose (“undisclosed group”). The association between whether they talked with their children about their cancer and their conversations about the possibility of death were examined.
Results
A total of 370 participants were analyzed (80.8% female, median age 43.0 years). The disclosed group (n = 274, 74.1%) wanted to know what their child felt than the undisclosed group (p < 0.001). The undisclosed group didn’t want their children to see their suffering (p = 0.002) and didn’t know how to explain their disease condition ( p < 0.002). Both the disclosed (42.1%) and undisclosed (6.5%) groups told their children about the possibility of death.
Conclusion
This study showed the disclosed group wanted to know their children’s feelings and they tended to have a conversation about the possibility of death with their children, compared to the undisclosed group.
Skeletal and Alveolar Changes in Conventional Rapid Palatal Expansion (RPE) and Miniscrew-assisted RPE(MARPE): a Prospective Randomized Clinical Trial Using Low-dose CBCT
Authors: Chun Joo-Hee , Castro Amanda Cunha Regal , Oh Sunmee , Kim Kyung-Ho , Choi Sung-Hwan , Nojima Lincoln Issamu , Nojima Matilde da Cunha Gonçalves , Lee Kee-Joon
Published: January 2022

Background: This prospective randomized clinical trial aimed to evaluate the short-term effects of rapid palatal expansion (RPE) and miniscrew-assisted RPE (MARPE) on skeletal, dentoalveolar, and periodontal structures in adolescent and young adult patients. Methods: Thirty-six patients (12 men and 24 women) requiring maxillary expansion were randomly allocated to RPE (n=17) or MARPE (n=19) groups. Upon identical (35 turns) amount of expansion, low-dose cone-beam computed tomography images were taken before treatment (T0), immediately after expansion (T1), and after a 3-month consolidation period (T2). Skeletal, dentoalveolar, and periodontal measurements were performed at each time point. Results: A greater increase in nasal width in the molar region (M-NW) and greater palatine foramen (GPF) was observed immediately after expansion (T1-T0) and consolidation periods (T2-T0) in MARPE group (P<0.05). MARPE and RPE groups showed similar dentoalveolar changes except for the maxillary width (PM-MW, M-MW) (P<0.05). Through the expansion and consolidation periods (T2-T0), lesser buccal displacement of the anchor teeth was observed in the MARPE group (PM-BBPT, PM-PBPT, M-BBPT [mesial and distal roots], and M-PBPT) (P<0.05).Conclusions: Both RPE and MARPE groups exhibited significant triangular basal bone expansion and skeletal relapse during consolidation. Under identical amounts of expansion, the MARPE group showed lower decrease in the skeletal, dentoalveolar and periodontal variables after consolidation. The reinforcement of RPE with miniscrews contributes to the maintenance of the basal bone during consolidation period. This evidence can help clinicians decide the appliance design for maxillary expansion, while preventing periodontal side effects, such as buccal bone dehiscence Trial registration: WHO Institutional Clinical Trials Registry Platform (IRB No. KCT0006871 / Registration Date 27/12/2021)
Adding Rituximab to Chemotherapy for Diffuse Large B-Cell Lymphoma Patients in Indonesia: A Cost Utility and Budget Impact Analysis
Authors: Putri Septiara , Setiawan Ery , Saldi Siti Rizny F. , Chandra Levina , Sari Euis Ratna , Megraini Amila , Nadjib Mardiati , Sastroasmoro Sudigdo , Armansyah Armansyah
Published: January 2022

Background
This study aims to estimate the cost-effectiveness and budget impact of rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) compared to CHOP for the treatment of patients with diffuse large B-cell lymphoma (DLBCL) in Indonesia.
Methods
We conducted a cost utility analysis using Markov model over a lifetime horizon, from a societal perspective. Clinical evidence was derived from published clinical trials. Direct medical costs were gathered from hospital data. Direct non-medical costs, indirect costs, and utility data were primarily gathered by interviewing the patients. We applied 3% discount rate for both costs and effect. All monetary data are converted into USD (1 USD = IDR 14,000, 2019). Probabilistic sensitivity analysis was performed. In addition, from a payer perspective, budget impact analysis was estimated using price reduction scenarios.
Results
The incremental cost-effectiveness ratio (ICER) of R-CHOP was USD 4,674/LYG and 9,280/QALY. If we refer to the threshold three times the GDP per capita (USD 11,538), R-CHOP could thus be determined as a cost-effective therapy. Its significant health benefit has contributed to the considerable ICER result. Although the R-CHOP has been considered a cost-effective intervention, the financial consequence of R-CHOP if remain in benefit package under National Health Insurance (NHI) system in Indonesia is considerably substantial, approximately USD 66 million with 75% price reduction scenario.
Conclusions
As a favorable treatment for DLBCL, R-CHOP ensures value for money in Indonesia. Budget impact analysis provides results which can be used as further consideration for decision-makers in matters related to benefit packages.
FBLN5 Is an Underlying Common Tumor Suppressor in Breast Cancer and Thyroid Cancer
Authors: XIE Zhao-min , XIAO Ying-sheng , XU Chun-yan , XIE Qin , WANG Wen-de , WANG Zheng-hao , LIANG Yuan-ke , LIN Hao-yu , ZENG De
Published: January 2022

Background: Breast cancer (BC) patients have a greater risk of developing thyroid cancer (TC) than the general population. Similarly, TC patients are more likely to develop BC, suggesting an underlying common etiology. In this study, we sought to identify the potential cross-talking pathway and related molecular mechanisms conferring to the sequential development of BC and TC.Methods: We first used Multiple Primary-Standardized Incidence Ratios (MP-SIR) Program of SEER*Stat to calculate SIR to confirm the relationship between BC and TC. Then the RNA-seq was downloaded from The Cancer Genome Atlas (TCGA). And we built a co-expression network via Weighted Gene Co-expression Network Analysis (WGCNA) and obtained the most significant modules. The key genes were obtained by differential gene expression (DGE) analysis and WGCNA analysis. Furthermore, String database and Cytoscape software were used to construct protein-protein interactions (PPI), and defined the maximum Maximal Clique Centrality (MCC) value as hub gene.Then we performed prognosis analysis on the hub genes and obtained the prognostic genes of BC and TC. Finally, gene set enrichment analysis (GSEA) was used to investigate the molecular pathways associated with prognostic gene expressed both in BC and TC.Results: From the SEER database, we found that the risk of developing BC in TC patients was SIR 1.12, 95% CI [1.07, 1.18], and the risk of developing BC in TC patients was SIR 1.29, 95% CI [1.23, 1.26]. Fifty-nine key genes obtained by differential expression analysis and WGCNA identify that PI3K/AKT was the most enriched pathway in BC and TC. In addition, the Recombinant Fibulin 5 (FBLN5) was shown to be of significant prognostic value for both BC and TC and was down-regulated in BC and TC tissues. GSEA demonstrated that FBLN5 enrichment pathways associated with BC and TC mainly included: B cell receptor signaling pathway, steroid hormone biosynthesis, and pathways in cancer.Conclusions: The PI3K/AKT signaling is most co-enriched pathway in BC and TC. FBLN5 is the most relevant prognostic gene and an underlying common tumor suppressor in both BC and TC, with down-stream pathways involving immunity, hormone biosynthesis and carcinogenesis.
Measuring Treatment Attrition at Various Stages of Engagement in Opioid Agonist Treatment in Ontario Canada Using a Cascade of Care Framework
Authors: Tahsin Farah , Morin Kristen A. , Vojtesek Frank , Marsh David C.
Published: January 2022

Background
The cascade of care framework is an effective way to measure attrition at various stages of engagement in Opioid Agonist Treatment (OAT). The primary objective of the study was to describe the cascade of care for individuals who have accessed OAT from a network of specialized addiction clinics in Ontario, Canada. The secondary objectives were to evaluate correlates associated with retention in OAT at various stages and the impact of patients' location of the residence on retention in OAT.
Design:
A multi-clinic retrospective cohort study was conducted using electronic medical record (EMR) data from the largest network of OAT clinics in Canada (70 clinics) from 2014-2020. Study participants included all individuals who received OAT from the network of clinics during the study period.
Measurements:
In this study, four stages of the cascade of care framework were operationalized to identify treatment engagement patterns, including patients retained within 90 days, 90 to 365 days, one to two years, and more than two years. Correlates associated with OAT retention for 90 days, 90 to 365 days, one to two years, and more than two years were also evaluated and compared across rural and urban areas in northern and southern Ontario.
Results
A total of 32,487 individuals were included in the study. Compared to individuals who were retained in OAT for 90 days, individuals who were retained for 90 to 365 days, one to two years, or more than two years were more likely to have a higher number of treatment attempts, a higher number of average monthly urine drug screening and a lower proportion of positive urine drug screening results for other drug use.
Conclusion
Distinct sociodemographic and clinical factors are likely to influence treatment retention at various stages of engagement along the OAT continuum. Research is required to determine if tailored strategies specific to people at different stages of engagement have the potential to improve outcomes of OAT.
Study on Spinnability of Arabinoxylan Extracted From Barley Husks
Authors: Butylina Svetlana , Koljonen Krista , Hiltunen Salla , Laatikainen Katri
Published: January 2022

Valorisation of bio-based materials derived from agricultural and industrial side-streams or waste-streams is a basis of circular economy. However, the success of it depends on the full understanding of materials and finding their optimal way of processing. Barley husk is a side-stream waste material derived from the starch and ethanol production. This study is focused on the processability of the arabinoxylan extracted from barley husk using the electrospinning technique to produce thin xylan-poly(vinyl alcohol) fibers. As a comparison, lignin-free xylan of beech wood was used. The properties of spinning solutions and resulting nanofibrous mats were assessed by using rheological measurements, FTIR spectroscopy, scanning electron microscopy and contact angle measurements. It was found that solubility plays a crucial role in the spinnability of xylan extracts. Decrease in viscosity of arabinoxylan achieved by decreasing its concentration was found to improve the jet stability but at the same time, to reduce the diameter of spun fibre. Hydrophilicity of nanofibrous mats were strongly affected by the type of xylan and solvent used.
The Experience of Participating in an Internet-Based Cognitive Behavioral Therapy Program Among Patients with Cardiovascular Disease and Depression: A Qualitative Interview Study
Authors: Westas Mats , Mourad Ghassan , Andersson Gerhard , Neher Margit , Lundgren Johan , Johansson Peter
Published: January 2022

Background
Depression in cardiovascular disease (CVD) is associated with poor outcomes and there is a treatment gap of depression in CVD patients. Recently we found that an Internet-based cognitive behavioral therapy (iCBT) tailored for CVD patients led to reduced symptoms of depression. However, we still have little knowledge about CVD patients’ experiences of working with iCBT. The aim of this study was therefore to explore CVD patients experience of engaging with a tailored iCBT program.
Methods
A qualitative interview study using inductive thematic analysis. Data was obtained from 20 patients with CVD and depressive symptoms who had participated in a randomized controlled trial (RCT) evaluating the impact of a nine-week iCBT program on depression.
Results
Three main themes emerged: (1) Taking control of the disease, (2) Not just a walk in the park, and (3) Feeling a personal engagement with the iCBT program. The first theme included comments that the tailored program gave the patients a feeling of being active in the treatment process and helped them achieve changes in thoughts and behaviors necessary to take control of their CVD. The second theme showed that patients also experienced the program as demanding and emotionally challenging. However, it was viewed as helpful to challenge negative thinking about living with CVD and to change depressive thoughts. In the third theme patients reported that the structure inherent in the program, in the form of organizing their own health and the scheduled feedback from the therapist created a feeling of being seen as an individual. The feeling of being acknowledged as a person also made it easier to continuously work with the changes necessary to improve their health.
Conclusions
Engaging in an iCBT program tailored for patients with CVD and depression was by the patients perceived as helpful in the treatment of depression. They experienced positive changes in emotions, thoughts, and behaviors which a result of learning to take control of their CVD, being confirmed and getting support. The patients considered working with the iCBT program as demanding and emotionally challenging, but necessary to achieve changes in emotions, thoughts, and behaviors.
An Integrated View of Homologous Emissions of Greenhouse Gases and Air Pollutants in China
Authors: Lin Xiaohui , Yang Ruqi , Zhang Wen , Zeng Ning , Zhao Yu , Wang Guocheng , Li Tingting , Cai Qixiang
Published: January 2022

Background: Air pollution in China has raised great concerns due to its adverse effects on air quality, human health, and climate. Emissions of air pollutants (APs) are inherently linked with CO2 emissions through fossil-energy consumption. Knowledge of the characteristics of APs and CO2 emissions and their relationships is fundamentally important in the pursuit of co-benefits in addressing air quality and climate issues in China. However, the linkages and interactions between APs and CO2 in China are not well understood.Results: Here, we conducted an ensemble study of six bottom-up inventories to identify the underlying drivers of APs and CO2 emissions growth and to explore their linkages in China. The results showed that, during 1980-2015, the power and industry sectors contributed 61–79% to China’s overall emissions of CO2, NOx, and SO2. In addition, the residential and industrial sectors were large emitters (77–85%) of PM10, PM2.5, CO, BC, and OC. The emissions of CH4, N2O and NH3 were dominated by the agriculture sector (46–82%), while the share of CH4 emissions in the energy sector increased since 2010. During 1980-2015, APs and greenhouse gases (GHGs) emissions from residential sources generally decreased over time, while the transportation sector increased its impact on recent emissions, particularly for NOx and NMVOC. Since implementation of stringent pollution control measures and accompanying technological improvements in 2013, China has effectively limited pollution emissions (e.g., growth rates of –10% per year for PM and –20% for SO2) and slowed down the increasing trend of carbon emissions from the power and industrial sectors. We also found that areas with high emissions of CO, NOx, NMVOC, and SO2 also emitted large amounts of CO2, which demonstrates the possible common sources of APs and GHGs. Moreover, we found significant correlations between CO2 and APs (e.g., NOx, CO, SO2, and PM) emissions in the top 5% high-emitting grid cells, with more than 60% common/overlapped grid cells during 2010–2015. Conclusions: We found significant homology in spatial and temporal aspects for CO2, and NOx, CO, SO2, and PM emissions in China. We targeted sectorial and spatial APs and GHGs emission hot-spots, which help for management and policy-making of collaborative reductions of them. This comprehensive analysis over 6 datasets improves our understanding of APs and GHGs emissions in China during the period of rapid industrialization from 1980 to 2015. This study helps elucidate the linkages between APs and CO2 from an integrated perspective, and provides insights for future synergistic emissions reduction.
The Efficacy of Baricitinib in Real-World Patients with Refractory or Severe Juvenile Dermatomyositis:A Monocentric Retrospective Study
Authors: Wang Zhaoling , Zheng Qi , Xu XiSheng , Lu Meiping
Published: January 2022

Objective
To evaluate the efficacy and safety of low dose baricitinib in children with refractory or severe juvenile dermatomyositis (JDM) in a real-world setting.
Methods
A monocentric retrospective real-world study was conducted, in which fourteen refractory and one severe newly diagnosed JDM patients were included. These patients were all treated by low dose baricitinib (below the recommended dose) combined with corticosteroids and or immunosuppressive agents. Clinical data were collected at the baseline and 4, 12, 24 weeks after baricitinib implication. Treatment response (complete response (CR), Partial response (PR) and non-response (NR)) was evaluated using both the Paediatric Rheumatology International Trials Organization (PRINTO) remission criteria and skin Disease Activity Score (DAS). All the adverse events (AEs) were recorded.
Results
After baricitinib treatment, all 15 patients showed improvement of skin involvement, including 14 patients with recurrent skin rashes and one newly diagnosed JDM. Calcinosis stabilized in two patients (2/3) and partially regressed in one. Four patients (4/15) had interstitial lung disease (ILD), which normalized in one, improved in two and stabilized in one. One patient complicated with macrophage activation syndrome (MAS) achieved clinical remission. CR was achieved in 3/15 patients, ranging from 4 to 12 weeks after baricitinib initiation. Five patients (5/15) got PR 4 to 24 weeks after baricitinib use. Daily steroid dosage was decreased from 0.632 mg/kg to 0.357 mg/kg (P = 0.043) at 24 weeks in all responders. However, there was no statistically difference in muscle improvement. One patient was stopped using baricitinib because of varicella zoster virus infection, while no other serious side effect was observed in this study.
Conclusion
Low dose baricitinib had efficacy and was safe to applied in refractory or severe JDM patients, especially for recurrent skin rashes. Baricitinib may also be helpful for JDM complicated with ILD and MAS.
Dynamic Regulation of Lipid Metabolism in the Placenta of in Vitro and in Vivo Models of Gestational Diabetes Mellitus
Authors: Kim So Young , Lee Young Joo , An Sung-Min , Kim Min Jae , Jeong Jea Sic , Kim Da Som , Lim Yong , Jung Eui-Man , Kim Seung-Chul , An Beum-Soo
Published: January 2022

Background: The purpose of this study was to investigate lipid metabolism in the placenta of Gestational diabetes mellitus (GDM) individuals and to evaluate its effect on the fetus. Methods: We examined the expression of lipogenesis- and lipolysis-related proteins in the in vitro and in vivo GDM placenta models. Results: The levels of sterol regulatory element binding protein-1c (SREBP-1c) were increased, and fat accumulated more during early hyperglycemia, indicating that lipogenesis was stimulated. When hyperglycemia was further extended, lipolysis was activated due to the phosphorylation of hormone-sensitive lipase (HSL) and expression of adipose triglyceride lipase (ATGL). In the animal model of GDM and in the placenta of GDM patients during the extended stage of GDM, the expression of SREBP-1c decreased and the deposition of fat increased. Similar to the results obtained in the in vitro study, lipolysis was enhanced in the animal and human placenta of extended GDM. Conclusion: These results suggest that fat synthesis may be stimulated by lipogenesis in the placenta when the blood glucose level is high. Subsequently, the accumulated fat can be degraded by lipolysis and more fat and its metabolites can be delivered to the fetus when the GDM condition is extended at the late stage of gestation. Imbalanced fat metabolism in the placenta and fetus of GDM patients can cause metabolic complications in the fetus, including fetal macrosomia, obesity, and type 2 diabetes mellitus.
A Case of Early-Onset Alzheimer's Disease with MAPT P301L Mutation and Literature Review
Authors: Li Jia , Feng Jingqi , Su Hang , Chen Jiajun
Published: January 2022

Background: Early-onset Alzheimer's disease is defined as Parkinson's disease that begins at an age of 65 or younger. Currently, among the reports on early-onset Alzheimer's disease related genes, mutations of APP, PSEN1 and PSEN2 genes are relatively common, However, the mutation of MAPT P301L causes early-onset Alzheimer's disease, which has not been reported so far. Case report: We have found a clinical case of a 30-year-old male who suddenly developed cognitive impairment and progressed rapidly within 2 years, leaving him unable to take care of himself. The patient underwent examinations of blood and cerebrospinal fluid routine, biochemistry and immunoassay, as well as imaging examinations of MRI, FDGPET and PIBPET. PIB-PET indicated diffuse heterogeneous radionuclivity in cerebral cortex, and positive PIB imaging was considered. Sequencing results suggested that there was a heterozygous mutation in the MAPT gene of the patient, which was located in Chr17-44087755, and c.902C>T. Conclusion: We speculated that EOAD of this patient may be related to the P301L mutation on MAPT.
Contrast Enhancing Pattern on Pre-Treatment MRI predicts Response to Anti-Angiogenic Treatment in Recurrent Glioblastoma: Comparison of Bevacizumab and Temozolomide Treatment
Authors: Moon Hye Hyeon , Park Ji Eun , Kim Young-Hoon , Kim Jeong Hoon , Kim Ho Sung
Published: January 2022

Objective: To evaluate the value of the contrast enhancing pattern on pre-treatment MRI for predicting the response to anti-angiogenic treatment in patients with IDH-wild type recurrent glioblastoma.Methods: This retrospective study enrolled 65 patients with IDH wild-type recurrent glioblastoma who received standard therapy and then received either bevacizumab (46 patients) or temozolomide (19 patients) as a secondary treatment. The contrast enhancing pattern on pre-treatment MRI was visually analyzed and dichotomized into contrast enhancing lesion (CEL) dominant and non-enhancing lesion (NEL) dominant types. Quantitative volumetric analysis was used to support the dichotomization. The Kaplan-Meier method and Cox proportional hazards regression analysis were used to stratify progression free survival (PFS) according to the treatment in the entire patients, CEL dominant group, and NEL dominant group.Results: In all patients, the PFS of those treated with bevacizumab was not significantly different from those treated with temozolomide (log-rank test, P=.96). When the contrast enhancing pattern was considered, bevacizumab was associated with longer PFS in the CEL dominant group (P=.031), whereas temozolomide showed longer PFS in the NEL dominant group (P=.022). Quantitative analysis revealed cut-offs for the proportion of solid-enhancing tumor of 13.7% for the CEL dominant group and 4.3% for the NEL dominant group. Conclusions: Patients with the CEL dominant type showed a better treatment response to bevacizumab, whereas NEL dominant types showed a better response to temozolomide. The contrast enhancing pattern on pre-treatment MRI can be used to stratify patients with IDH wild-type recurrent glioblastoma according to the effect of anti-angiogenic treatment.
Behavior analytic technologies mediated via augmented reality for autism: A systematic review
Authors: Neely Leslie , Carnett Amarie , Quarles John , Park Se-Woong , Kelly Michelle
Published: January 2022

This review synthesizes the literature base evaluating the effects of behavior analytic interventions delivered via augmented reality (AR) technology for individuals with autism. We also conducted a quality review. We identified 14 studies with a majority of the studies (n = 11; 79%) utilizing single-case research design. Of the 14 studies, three met the quality criteria to be classified as “strong” and can offer evidence on the integration of AR technology into the practice of behavior analysis. All three studies taught a functional skill (i.e., tooth brushing and navigation). The remaining studies focused on skill acquisition with zero studies utilizing AR within the context of behavior assessment or behavior reduction interventions. This literature base is emerging with additional research required.
Perceptions of Cannabis in sub-Saharan Africa: Findings from a general population survey in six African countries with different Cannabis policies.
Authors: Kitchen Chenai , Kabba John Alimamy , Ssekamatte Tonny , Nelson Ediomo-Ubong , Adu-Gyamfi Samuel , Mametja Molewane , Yang Caijun , Chang Jie , Fang Yu
Published: January 2022

Background

Recently, legislative shifts in cannabis regulation away from exclusively prohibitionist controls have been seen in sub-Saharan African countries. However, the extent to which public perceptions are aligned with policy trends is unclear. Given that views concerning cannabis may be influenced by associated legislation we aimed to compare public opinion towards cannabis amongst countries with legislatively different cannabis policies.
Methods

We conducted an online survey of the general adult population in six purposively selected countries representative of maximum policy variation across sub-Saharan Africa i.e., Ghana, Nigeria, Sierra Leone, South Africa and Zimbabwe. Survey questions covered perceptions towards users, risks and benefits, regulations and public health impacts as well as sociodemographic characteristics. Chi square tests were used to analyse the association between categorical variables and explore country level differences.
Results

Totally 1216 responses were received. Large variations were noted in responses towards user stereotypes, risks and preferred legislation. In relation to users being honest (X2=43.316, P<0.0001), most in Sierra Leone(52.9%), Nigeria (45.6%) and Uganda(48.6%) disagreed whereas in Ghana(39.4%), South Africa(43.3%) and Zimbabwe(40.1%) most agreed. Differences in smoking cannabis and smoking tobacco products(X2= 27.712, P=0.002) saw respondents from Ghana(51.4%), Nigeria(58.8%), Uganda(50.9%) and Zimbabwe(46.8%) agreeing that smoking cannabis is more harmful to health, whereas majorities in Sierra Leone(45.7%) and South Africa(49.8%) disagreed. Apart from South Africa were the greater proportion opted to allow cannabis for all purposes(28.8%), majorities in other countries supported only medicinal legalisation(X2= 96.631, P<0.0001).
Conclusion

Dependent upon the question of focus, at the liberal end of the policy spectrum are Ghana, South Africa and Zimbabwe whilst Nigeria, Sierra Leone and Uganda were more conservative. Responses tended to reflect the policy position of respective countries, however our findings suggest overall increasing medicinal cannabis support. Greater understanding of policy dynamics may help create frameworks for countries contemplating reforms.
Evaluation of Sulfentrazone Alone or in Combination with Other PRE and POST Herbicides for Weed Control in Tomato (Solanum lycopersicum) and Strawberry (Fragaria ×ananassa)
Authors: Sandhu Ravneet K. , Reuss Laura E. , Boyd Nathan S.
Published: January 2022

Sulfentrazone was recently registered for use in tomato and strawberry in Florida. Field experiments were conducted at the Gulf Coast Research and Education Center in Wimauma, FL, to evaluate PRE sulfentrazone applications when applied on flat soil 30 days before bed formation (PRE-f), on the bed top immediately before laying plastic mulch (PRE-t), applied PRE-t as a tank mix with other PRE herbicides, or PRE-t followed by POST halosulfuron or rimusulfuron (POST). Sulfentrazone did not damage the tomato and strawberry crop and had no effect on strawberry and tomato fruit yield. It was as effective as the industry standards but none of the evaluated herbicide treatments provided adequate weed control. POST halosulfuron in tomato resulted in significantly greater nutsedge control at 11 (14%) and 13 (27%) weeks after initial treatment (WAIT) compared with other treatments in Fall 2019 and Spring 2020, respectively. However, in tomato, tank-mixing sulfentrazone with S-metolachlor or metribuzin did not enhance nutsedge control. Weed control did not improve with increased rates or with the use of PRE-f followed by (fb) PRE-t applications in tomato. PRE-t sulfentrazone fb POST halosulfuron was an efficient nutsedge management option in tomato. Sulfentrazone alone did not effectively control weeds in tomato or strawberry. Increased rates of sulfentrazone with the use of PRE-f fb PRE-t sulfentrazone applications did reduce (34%) total weed density in strawberry.
The methodology of food design. Part 2. Digital nutritiology in personal food
Authors: Prosekov A. Y. , Vesnina A. D. , Kozlova O. V.
Published: January 2022

Atherosclerosis (the main cause of a wide range of cardiovascular diseases) and other multifactorial diseases depend on several nutrition factors, defined in general by lifestyle that directly and constantly affects the human body. The modern level of science and technology development is able to form a diet, taking into account all personal characteristics in such a way that makes nutrition an effective preventive measure against diseases in order to keep a person healthy. The purpose of this article is to define and study all the limitations (the scope of its coverage in the scientific literature) that arose in the process of research aimed to formation of an integrated personal approach to designing of nutrition to prevent atherosclerosis. The object of the study was scientific literature, which is available in open source and free access databases: PubMed, ScienceDirect, eLIBRARY.RU, www.fips.ru, Patentscope. The language of search is Russian and English, search depth is 12 years. In the course of the research two food design concepts were found that affect process of digitalization in the food sector: the concept “FoodTech” (food technology) and digital nutritiology. It was established that in Russia only one company — LLC “City Supermarket” (Moscow), that works with the brand “Azbuka Vkusa” — acts in the sphere of “FoodTech” on the Russian market. This company selects personalized food, taking into account the results of personal nutrigenetic tests, in cooperation with LLC “Genotech” (Moscow). There is a need to use biological information, statistical information processing (nutrigenetic studies, nutrigenomic research) and machine-aided data processing (machine learning) for further generation of automatic algorithm that compiles personal recommendations. The relevance of generation of a national domestic database on chemical composition of food products (presented in the market) to simplify the preparation of individual personal diets is observed. We underline the necessity to use the test-organisms, i. e. dorio fish / zebrafish (Danio rerio) and nematodes (Caenorhabditis elegans)), which were used to determine the activity of candidate substances — the biologically active substances that feature antiatherosclerotic properties. In the future the authors plan to conduct a nutrigenomic and nutrigenetic study, using digital achievements. To collect information about consumers, it is necessary to apply digital devices, and use biological informatics to process the results; after that it is necessary to generate the algorithm for automatic selection of personalized dietary recommendations.
Meat consumption: theory, practice and future prospects
Authors: Putnik P. , Kovačević D. B.
Published: January 2022

This research reviewed human meat consumption and highlighted associated history, challenges and benefits. Selected literature for the manuscript was from relevant titles and reliable international sources. From early times of the mankind meat consumption and animal husbandry were inseparable parts of living, and with similar consequences as dramatic influence on environment. Human need for meat consumption fueled development of large world markets with incredible trade, processing and consumption. This overconsumption has caused health problems associated with high intake of cholesterol and sodium chloride. Another problem with meat consumption is the use of additives in processed products. In modern time these problems are tackled by the use of additives from plants that have health benefits. Thermal processing is yet another problem with meat consumption that food industry and science addresses by non-thermal replacements (e. g. high-pressure processing and electrotechnologies). Recently, interesting alternatives for meat processing included 3D Printing that is able to engineer admirable meat products from by-products. However, this technology might need to employ enzymes such as transglutaminase, associated with potential health problems and misleading the customers. Unfortunately, fraudulent activities are common for meat products and it would be prudent to organize enforcement centers with at least police and analysts skilled in chemometrics and various laboratory techniques for food defense. It seems as humankind expands it will seek more proteins from plant, insects, unicellular biomass, and synthetic meat than from the animal origin, however all of the alternatives must be carefully evaluated against consumer acceptance, public health and environmental concerns.
Delphi Yöntemi Kullanarak Afet Sonrası Geçici Barınma Alanı Seçimi ve Planlaması Ölçütlerinin Belirlenmesi: İzmir/Seferihisar Örneği
Authors: DAYANIR Hande , ÇINAR Ali Kemal , AKGÜN Yenal , ÇORUMLUOĞLU Özşen
Published: January 2022

Afet sonrası geçici barınma alanlarının gerekli ölçütlere uygun olarak yer seçimlerinin yapılması ve vaziyet planlarının tasarımı, afet ve risk yönetimi çalışmalarının en önemli konularındandır. Türkiye’de bu konu Afet ve Acil Durum Yönetim Başkanlığı (AFAD) tarafından koordine edilmektedir. AFAD tarafından 2015 yılında ilan edilen “Geçici Barınma Merkezlerinin Kurulması, Yönetilmesi ve İşletilmesi Hakkında Yönerge” ulusal ölçütleri büyük ölçüde tanımlasa da, uluslararası literatürdeki kadar detaylandırılmamış ve ölçütler önemlerine göre derecelendirilmemiştir. Ayrıca, AFAD tarafından İzmir ili için önerilmiş olan afet sonrası geçici barınma alanlarının, ulusal ve uluslararası mevzuata ve literatürdeki çalışmalarda önerilen ölçütlere uygunluğunun değerlendirilmesi de bilinebildiği kadarıyla henüz yapılmamıştır. Bu kapsamda çalışmanın ilk amacı, afet sonrası geçici barınma alanlarının yer seçimi, planlama ve tasarımına dair ölçütlerin Delphi yöntemi kullanılarak derlenmesi, gruplanması, tanımlanması ve derecelendirilmesidir. Delphi yöntemi ile ortaya konan yer seçim-planlama ölçütleri listesi yardımıyla İzmir için önerilmiş olan afet sonrası geçici barınma alanlarının uygunluk analizinin yapılması çalışmanın bir diğer amacıdır. Delphi yöntemi ile yapılan üç aşamalı panel sonucunda oluşan ölçütler listesine göre, İzmir’de sınırlı sayıda alanın gereklilikleri karşılayabildiği tespit edilmiştir. Bu alanlardan biri olan Seferihisar2 alanının neden en uygun alan olduğu açıklanmış, yine Delphi yöntemi ile elde edilen tasarım-uygulama ölçütlerine dayanarak alan üzerinde örnek bir konteyner-kent vaziyet planı yapılmıştır.
Unbounded entanglement production via a dissipative impurity
Authors: Alba Vincenzo
Published: January 2022

We investigate the entanglement dynamics in a free-fermion chain initially
prepared in a Fermi sea and subjected to
localized losses (dissipative impurity). We derive a formula describing the dynamics
of the entanglement entropies in
the hydrodynamic limit of long times and large intervals.
The result depends only on the absorption coefficient of the effective
delta potential describing the impurity in the hydrodynamic limit.
Genuine dissipation-induced entanglement is certified by
the linear growth of the logarithmic negativity.
Finally, in the quantum Zeno regime at strong dissipation the entanglement growth is
arrested (Zeno entanglement death).
Психологическая работа с семьей: особенности взаимодействия в процессе формирования детско-родительских отношений
Authors:   ФГКОУ ВО «Академия управления Министерства внутренних дел Российской Федерации МВД России», Вахнина В.В. ,   ГБПОУ г. Москвы Колледж по подготовке социальных работников, Васильева В.А.
Published: January 2022

В статье исследуется феномен межличностного взаимодействия как процесс психологического воздействия. В структуре межличностного взаимодействия выделяются три основных компонента: побудительную, когнитивную и регулятивную. Эффективность межличностного взаимодействия, по мнению авторов, обусловлена психологическим механизмом мотивационно-целевого взаимодействия, т.е. согласование целей и мотивов противоборствующих сторон, позволяет формировать совпадающие интересы, находить общие цели, совместными усилиями достигать их.
Развитие диагностического мышления студентов педагогов-психологов с помощью автоматизированных кейс-систем по психолого-педагогической диагностике
Authors:   я ФГБОУ ВО “Московский педагогический государственный университет”, Ануфриев А.Ф. , Ферапонтова М.В.
Published: January 2022

Статья посвящена исследованию возможностей развития диагностического мышления студентов выпускных курсов – будущих педагогов-психологов с помощью автоматизированных кейс-систем по психолого-педагогической диагностике. На основе индивидуальной способности к диагностике выборка разделена на две группы: испытуемые с низким и высоким уровнем способности к диагностике. С каждой из подгрупп был проведен психолого-педагогический эксперимент, в ходе которого происходило формирование диагностического мышления в форме решения компьютерных задач по психолого-педагогической диагностике. Статистический анализ данных позволил установить, что у педагогов-психологов с высоким и низким уровнем способности к диагностике имеются значительные (статистически значимые) отличия в уровне развития диагностического мышления.