bluuebunny/crossref_metadata_2025 huggingface dataset:
The Legacy of Early Translation Theory: Challenges and Contemporary Perspectives
Authors: Hanane BELGAID
Published: December 2024

This article critically examines the origins of translation theory, underscoring the essential role of historical context in understanding contemporary debates and methodologies. It delves into foundational intellectual confrontations, such as those between the followers of D’Ablancourt and the Jansenist pedagogues of Port-Royal, which continue to inform current discussions on fidelity, creativity, and the problem of untranslatability. The paper advocates for a diachronic approach to translation theory, recognizing the lasting influence of early theorists like De Méziriac and Tytler on the field. By revisiting these historical intellectual exchanges, the article demonstrates how enduring issues related to translation’s nature—whether as a science, an art, or a practice—continue to shape modern translation studies, influencing contemporary methodologies such as skopos theory and interpretive frameworks.
Cultivating Emotional and Social Development in Early Learners
Authors: Lyza Marie Chan Lauronilla  , Helen Revalde  , Adrian Duites  , Kaitlin Marie Opingo  , Randy Mangubat  , Raymond Espina
Published: December 2024

This study aimed to examine the relationship between social-emotional development and academic performance among early childhood learners A quantitative descriptive correlational research design was used. Data on social-emotional development were gathered through a structured questionnaire assessing emotional awareness and expression, self-regulation, social skills, relationships with adults, and pro-social behavior. Academic performance in literacy and numeracy was obtained from school records. Statistical analysis, including Pearson’s correlation, was applied to determine the relationship between socio-emotional competencies and academic outcomes. Results showed that while learners displayed strong social-emotional competencies across various domains, no statistically significant relationship was found between these competencies and academic performance in literacy or numeracy. The findings suggest that other factors may play a more crucial role in predicting academic success, and further research is recommended to explore additional influences on early childhood academic outcomes. Ethical considerations were maintained throughout the study.
Supporting the drive for net zero by decarbonising general practice – A longitudinal study protocol
Authors: Nunes Ana Raquel , Atherton Helen , Dahlmann Frederik , Eccles Abi , Geddes Olivia , Gregg Michael , Jowett Sue , Karaba Florence , Nelson Laura , Spencer Rachel , Twohig Helen , Dale Jeremy
Published: December 2024

Introduction The urgency to address climate change and reduce carbon emissions in healthcare, highlighted in the United Kingdom (UK) by the 'Delivering a 'Net Zero' National Health Service (NHS)' report, emphasises the need for healthcare organisations to adopt and integrate sustainability practices. General practice is recognised as a major source of greenhouse gas emissions, but evidence on achieving effective decarbonisation in general practice is limited, a knowledge gap that urgently needs further research. This study aims to examine the current approaches general practice uses for decarbonisation and to provide practical recommendations for facilitating, advancing, and sustaining these efforts, contributing to the goal of a net zero NHS. Methods and analysis This 30-month longitudinal case study spans three geographical sites in England and uses a mixed methods study design. It adopts a comprehensive approach, merging sociological (Normalisation Process Theory - NPT) and behavioural theories (Theoretical Domains Framework - TDF) to understand and address factors influencing decarbonisation efforts in general practice. NPT focuses on collective behaviours, emphasising relationships and interactions among professionals, patients, and stakeholders. TDF, with 14 domains simplifying behavioural change theories, concentrates on individual, social, and environmental factors. A systematic review will be conducted, and quantitative and qualitative data will be collected over a 12-month period from general practice, staff, patients, public, and key stakeholders’ perspectives through surveys, interviews, and focus groups. Additionally, a non-clinical carbon calculator, alongside prescribing data, will be gathered to assess measurable changes in carbon emissions, informing a budget impact model for practice-specific and generic use. Dissemination A dynamic dissemination and impact strategy is aimed at ensuring broad awareness, adoption, and accelerated uptake of decarbonisation measures. Outputs, including lay summaries, factsheets, policy briefs and academic presentations will be produced throughout the study and undergo regular review, targeting key audiences and ensuring alignment with regional and national goals.
Strategic development of enterprises in the new normal: digital transformations and innovative approaches to adaptation to changes and entropy resilience
Authors: Tepliuk Mariia , Sergienko Maria , Kyryliuk Oksana
Published: December 2024

The article is devoted to the analysis of the strategic development of enterprises in the conditions of the new normality, which was formed under the influence of the COVID-19 pandemic, the war in Ukraine and global economic crises. The authors highlight the key aspects of enterprises’ adaptation to changes, in particular, digitalization, innovation, sustainable development and risk resistance. It is substantiated that in the modern world, characterized by ontological uncertainty, enterprises are forced to operate in the conditions of the new normality, which is dictated by global challenges, in particular: pandemic, economic crises, environmental threats, military actions and galloping digitalization. It is determined that the key problem is that traditional strategic approaches no longer provide an adequate response to the dynamics of being, which is transforming at breakneck speed. The importance of a flexible strategic approach that ensures the long-term competitiveness of enterprises in a dynamic environment is considered. The emphasis is on digital transformation as a basis for increasing the efficiency of business processes, using environmentally sound solutions for sustainable development and integration into global supply chains. The authors investigate the impact of government support, employee mental well-being and innovative approaches on the resilience of enterprises during the crisis. Macroeconomic indicators are analyzed, in particular, labor market recovery, fiscal stability and foreign trade, which form the basis for strategic development. The issues of enterprise adaptation to long-term crisis conditions, the balance between environmental responsibility and economic benefit, as well as effective integration into international markets are discussed. The article emphasizes the need for a systemic approach to change management, which involves the use of innovations, digital technologies and sustainable development strategies to maintain competitiveness in an ever-changing world.
Logical modeling of economic reforms in Ukraine
Authors: Sievidova Iryna , Susidenko Oleksii , Holovko Oleksandra
Published: December 2024

The article examines the logic of modeling economic reforms and their impact on the development of Ukraine in the context of transformation processes through the implementation of economic reforms in Ukraine and their impact on the development of the economy in the context of post-Soviet transformation processes. Strategies for increasing the rationality of logical modeling in the structure of national economy transformation processes are analyzed. It was determined that the logic of the reforms of the last few decades of Ukraine’s independence, aimed at the transformation from a planned economy to a market system, was based on the achievement of macroeconomic stability, deregulation, privatization, investment attraction, as well as on the strengthening of legal institutions and the European integration vector of development. An analysis of logical inconsistencies in approaches to reforms was carried out. Economic reforms in Ukraine were fragmented, which led to insufficient efficiency and uneven economic growth. Structural reforms in the agricultural and industrial sectors took place at different speeds, which created disproportions in the development of certain sectors of the economy. Only in the 2000s, the country’s economy began to show positive changes, which was the result of a number of macroeconomic stabilization measures, including fiscal discipline, currency stability, and market liberalization. It was found that the relevance of determining the significant factors of economic development lies in the comprehensive analysis of the cause-and-effect relationships between the implemented reforms and the logical modeling of their impact on economic growth. A detailed systematization of economic reforms requires the implementation of logical modeling according to the directions of transformation — deregulation, privatization, financial stabilization and institutional strengthening. Logical modeling of the structural relationships of dependence between reforms of various sectors of the economy, in particular, in the agrarian, financial and social sectors, will allow to determine how the reforms interact, influencing the general economic situation. It was determined that the implementation of logical modeling of future economic reforms into practice will allow optimizing economic processes by increasing the level of legal certainty and institutional capacity of the state.
Bacteriophage Therapy: Innovations, Mechanism, and Emerging Applications in Modern Medicine
Authors: Islam Md Sharifull , Supti Mahima Hossain , Acharjee Mrityunjoy
Published: December 2024

Bacteriophages, viruses that specifically target and kill bacteria, are among the most prevalent organisms on Earth. This paper explores the expanding applications of bacteriophages, particularly in the context of phage therapy, where virulent phages are employed to combat bacterial infections. With the rising threat of antibiotic resistance, bacteriophages offer a promising alternative for treating bacterial diseases in humans and animals. Their use extends beyond healthcare, playing a significant role in biocontrol in health and food safety. Bacteriophages not only eliminate harmful bacteria but also contribute to the natural balance of microbial populations, influencing microbial evolution through horizontal gene transfer. Furthermore, their versatility has led to applications in biotechnology, including vaccine delivery, microbial detection, and the development of systems for protein and antibody display. The ease with which bacteriophages can be manipulated has made them valuable tools in both therapeutic and research settings. This paper also advocates for the growth of phage production companies and the use of phage cocktails, which combine multiple phages, to address diverse bacterial infections at various stages. The promising future of bacteriophage-based therapies and their potential to revolutionize the treatment of bacterial diseases is underscored throughout.
Stam. J. Microbiol. 2024; 14(1): 28-35
Microbiological Safety of Drinking Water in Dhaka City: A Study on Supply and Treated Water in Dhaka, Bangladesh
Authors: Shathi Tahamina Akter , Roy Partha Bikash , Supti Mahima Hossain , Haque Nabila , Das Kamal Kanta
Published: December 2024

Access to safe and clean drinking water is a fundamental human right and a critical public health issue worldwide. The present study attempted to determine the microbiological quality and detection of pathogenic bacteria in different municipal water supplied in the different places of Dhaka city. This study involved the microbiological analysis of sixteen drinking water samples collected from diverse sources, including four from supply points, six from consumer points, and six treated water samples, obtained from Siddeswari, Sonargaon, Mirpur, and Badda. All the samples were contaminated with different microorganisms, and the total viable bacterial count ranged from 103 to 10⁷ CFU/mL. Pathogenic microbes like Pseudomonas spp. was present in all the samples, while Klebsiella spp., Salmonella spp., and Staphylococcus spp. were predominantly present in seven, six, and eleven samples, respectively. We also aimed to determine whether Shigella spp. was present in all the samples, but it was completely absent. Escherichia coli was detected in samples from both supply and consumer points within the range of 102 to 103 cfu/mL. The results indicate that the treatment procedure is not sufficiently effective in eliminating all pathogenic bacteria, and unhygienic environments contribute to post-treatment contamination. The study revealed that government should take necessary action to ensure public health safety, particularly with regard to access to safe drinking water.
Stam. J. Microbiol. 2024; 14(1):36-40
How Often is Microcarcinoma Thyroid Found in Non-Neoplastic Thyroidectomy Specimen? Eight Years of Experience in an Indonesian Academic Hospital
Authors: Fauziah Dyah , Kurniasari Nila , Agustin Leonita
Published: December 2024

Background: Papillary thyroid microcarcinoma (PTmC) is a subtype of papillary thyroid carcinoma characterized by a tumor that is no larger than 10 mm. This tumor is frequently discovered by accident during autopsies or in thyroidectomy specimens for other thyroid disorders. This study was conducted to ascertain the incidence of incidental PTmC in thyroidectomy specimens and analyze the clinicopathological characteristics.Methods: A descriptive cross-sectional study design was used. Pathology archives of thyroidectomy specimens between 2012 and 2019 in a single institution were collected. Cases with fine-needle aspiration biopsy (FNAB) before surgery were also studied. The clinical information was retrieved from medical records. Results: 1459 patients underwent thyroid surgery. The clinical diagnosis in 706 cases was neoplasm and in 753 cases was non-neoplasm. There were 697 cases of malignant thyroid tumors. Forty-two cases of papillary thyroid microcarcinoma were found, with 85.71% affected females, with the male-to-female ratio was 1:6. The majority of PTmC were clinically diagnosed as benign lesions with multinodular goiter as the most common diagnosis. Fine needle aspiration biopsies were performed on 18 patients. There were 2 cases found in laryngectomy specimens for laryngeal cancer. There were 2 cases presented initially as metastasis nodules in lymph nodes and the lung, respectively.Conclusions: PTmC comprises 6.03% of all malignant thyroid neoplasms and is mainly found incidentally in thyroidectomy specimens for benign thyroid lesions with clinical diagnosis as multinodular goiter. The male-to-female ratio is 1:6. Regional and distant metastasis are not common in PTmC.
Online Vs In-Class: EFL Students’ Oral Presentation Preferences
Authors: Rohmah Farida Noor
Published: December 2024

The objective of this study is to analyze the preferences and experiences of students with regards to in-class oral presentations as opposed to online oral presentations in English class. The participants for this study were 61 students selected purposively, with a concentration on students in their fourth semester at the Faculty of Health Sciences. The data were collected using a questionnaire and a semi-structured interview. The results show that students have a strong preference for online presentations, both in terms of general satisfaction and ease of preparation, indicating the perceived advantages of the online format over traditional in class presentations. The majority of students believe that online presentations improve their communication skills. The findings have important implications for educators and institutions seeking to improve the effectiveness of oral presentation methods.
Preservice Teachers’ Perceptions of Intercultural Communicative Competence: A Pathway to Peace and 21st Century Skills in Nepal
Authors: Kadel Purna Bahadur
Published: December 2024

Intercultural communicative competence is an essential attribute and phenomenon to maintain harmony and a sense of cosmopolitanism in a diverse and heterogeneous society like Nepal. This study explored preservice teachers’ perceptions of the importance of intercultural communicative competence and what specific 21st-century skills are enhanced by intercultural communicative competence. In order to address the research questions, the hermeneutic phenomenological research design was adopted to carry out this study. The in-depth- interview was administered as a tool to collect the lived experiences of the participants. Eight preservice teachers were selected from 4 strata: madheshi community, ethnic community, untouchable community, and brahmin community as participants for this study. The findings of this study were maintaining peace and promoting social cohesion, developing global citizens, prescribing ICC in school curriculum, blessing ICC for heterogeneous society, promoting ICC through English and Nepali languages, and enhancing 21st-century skills by ICC. Intercultural communicative competence plays a significant role in promoting human civilization, confidence, and sense of security in the society.
Clinical Outcomes of XEN45 Gel Stent Implantation (Ab Externo, Open Conjunctival Approach) versus Trabeculectomy: A Real-World Study
Authors: Park Hyunjin , Cho Hyuna , Kim Heesuk , Lee Jihei Sara , Kim Chan Yun , Bae Hyoung Won
Published: December 2024

Purpose: To compare the clinical outcomes of XEN45 gel stent implantation surgery (ab externo, open conjunctiva) with those of trabeculectomy.Methods: We retrospectively reviewed electronic medical record of 57 patients (62 eyes) treated with XEN implantation surgery (ab externo, open conjunctival approach) between April 1, 2021, and July 31, 2023, by the same surgeon. Preoperative clinical data including intraocular pressure (IOP), the number of glaucoma medications, and visual acuity were collected from 1 day to 12 months postoperatively. These data were compared and analyzed with those of 67 patients (78 eyes) received trabeculectomy between February 1, 2017, and April 30, 2022, by the same surgeon. Statistical analyses were performed with p < 0.05 as significant.Results: Complete surgical success rate was 33.9% and 57.7% of the XEN and trabeculectomy groups, respectively (p = 0.005). The qualified success rate was 79.0% and 93.6%, respectively (p = 0.011). Postoperatively, the XEN group used more glaucoma medications than the trabeculectomy group (1.21 ± 1.05 vs. 0.69 ± 0.90, p = 0.003 at postoperative month 12). After postoperative month 1, the XEN group had a higher IOP (15.77 ± 5.07 mmHg vs. 13.17 ± 3.81 mmHg; at postoperative month 12, p = 0.001) and lower corneal astigmatism than the trabeculectomy group (1.32 ± 0.79 diopters vs. 1.88 ± 1.45 diopters, p = 0.020 at postoperative month 6). There was no significant difference in preoperative and postoperative best-corrected visual acuity (logMAR) between the groups at any of the follow-up period (favorable visual acuity subgroup; logMAR < 0.7). Postoperative complications were 0 cases of XEN group and 13 cases of trabeculectomy group (0% vs. 16.7%, p = 0.001). Also, XEN surgery (24 minutes 40 seconds ± 6 minutes 26 seconds) had a shorter operation time than the trabeculectomy (40 minutes 18 seconds ± 8 minutes 27 seconds, p < 0.001).Conclusions: Compared to trabeculectomy, XEN surgery (ab externo, open conjunctiva) showed relatively lower effectiveness (surgical success rate, IOP reduction). However, it demonstrated advantages as a minimally invasive glaucoma surgery, including a surgical success rate approaching about 80%, stability in inducing corneal astigmatism, fewer postoperative complications, and shorter operation times.
7251 Sayılı Kanun’la Yapılan Değişikliklerden Sonra İlk Derece Hukuk Mahkemelerinde Tanık Listesinin Sunulma Zamanına İlişkin Uygulamanın Değerlendirilmesi
Authors: Acar Ayşe Ece
Published: December 2024

Medenî usûl hukuku uygulamasındaki güncel problemlerden biri, yargılama sırasında tanık listesinin sunulması gereken zamana dair ilk derece mahkemelerinin birbirinden farklı kararlar veriyor olmalarıdır. Özellikle 28 Temmuz 2020 tarihli Resmî Gazete’de yayımlanan 7251 sayılı Hukuk Muhakemeleri Kanunu ile Bazı Kanunlarda Değişiklik Yapılması Hakkında Kanun’un 6100 sayılı Hukuk Muhakemeleri Kanunu’nda getirmiş olduğu değişikliklerden sonra, belge niteliğindeki delillerin mahkemeye sunulma anına ilişkin yeni düzenlemenin farklı yorumlandığı ve yargılama sürecinin başında taraflardan tanık listelerini sunmalarının istendiği görülmektedir. Oysa tanık deliline yargılama sürecinin başında dayanılmalıdır, ancak yargılama sürecinin başında taraflardan tanık listesi sunmalarının beklenmesi yerinde değildir. Zira taraflardan ancak mahkeme tarafından ilgili uyuşmazlığın tanıkla ispatının mümkün olduğunun tespit edilmesinden ve tanık dinlenilmesine karar verilmesinden sonra tanık listelerini sunmaları beklenebilir. Bu hususların ise ön inceleme aşamasından önce belirlenebilmesi mümkün değildir. Çalışmamızda ilk olarak tanık deliline ve tanık listesinin sunulmasına dair genel esaslara değinilecek, sonrasında ise tanık listesinin sunulma zamanına dair öğretideki görüşler ve konuyla ilgili Yargıtay kararları eşliğinde tanık listesinin yargılama sürecinin başında sunulmasının istenmesinin hukuken yerinde olmadığına dair görüşümüzün gerekçeleri ortaya konulacaktır.
PENGARUH DISCOVERY LEARNING BERBANTUAN MEDIA AUDIOVISUAL TERHADAP PENINGKATAN KEMAMPUAN PEMECAHAN MASALAH MATEMATIKA
Authors: Ilfa Muhammad Khaza , Ardianti Sekar Dwi , Kuryanto Mohammad Syafruddin
Published: December 2024

The study is intended to learn the influence the discovery learning model was to assist audiovisual about the increased ability to solve the math problems of class IV students. It is conducted at Public Elementary School Klumpit 1, with a kind of quantitative research using a matode experiment of one group preposttest design. The sampling technique used in the study is the saturated sampling technique, with the number of students in the fourth class of students in the population of 10 boys and 15 girls. Pretest average value is 47.84. The posttest average is up to 80.36. The normal results of Shapiro-Wilk test that the pretest and posttest data above have sig > 0.05 with pretest data 0.054 > 0.05 and the posttest data 0.063 > 0.05 at significant levels 0.05 and n = 25, and H0 is accepted. N-gain tests, a value of 0.61 lies between 0.3 indicators 0.7 and a moderate increase in criteria. Thus it may be concluded that there is an increased ability to solve students' math problems through learning with the discovery learning model to assist audiovisual media.
ANALISA APLIKASI KONSEP TRANSFORMASI GEOMETRI PADA MOTIF BATIK LABAKO JEMBER
Authors: Saputra Muhammad Yusuf , Sulisawati Dwi Noviani , Murtinasari Frida
Published: December 2024

This research analyzes a continually evolving culture deeply ingrained in every region of Indonesia. Jember Regency, located in East Java, boasts a rich tapestry of cultures encompassing customs, food, language, games, and more. This research uses qualitative. The research focused on batik, specifically analyzing the geometric transformations within Labako batik motifs. These transformations include translation, reflection, rotation, and dilation. A total of eight motifs were identified from four Labako batik cloths, featuring elements like water hyacinth plants, bamboo, tomato and tobacco leaves, winged beans, and coffee and cocoa fruits and leaves. This research seeks to identify geometric concepts within each motif for use as teaching materials, indirectly promoting batik preservation and supporting Labako batik craftsmen. It is also hoped that this research can be used as a reference for future studies.
MENINGKATKAN LITERASI NUMERASI MELALUI PEMBELAJARAN BERDIFERENSIASI BERBANTUAN LKPD BERBASIS ETNOMATEMATIKA
Authors: Ayuningsih Ika , Anjariyah Deka , Wiyono Hari Joko
Published: December 2024

One of the important skills that students need to master is numeracy literacy. Teachers can improve this ability by integrating it into real-life context-based learning, while considering the characteristics of each student. The development of numeracy literacy can also be modified by incorporating local cultural elements. This study aims to assess the effectiveness of differentiated learning supported by ethnomathematics LKPD to improve students' numeracy literacy, reviewed from teacher activities, student activities, and numeracy literacy ability test results. The novelty of this study lies in the application of differentiated learning combined with Ethnomathematics-based LKPD that promotes Majapahit culture. The researcher used a quantitative descriptive method with a One Shot Case Study design. The sample of this study was taken using the Simple Random Sampling technique, which selected class VIII E of SMP Negeri 2 Bangsal with 32 students as the sample. Data were collected through observation and test techniques. The results of the study showed that teacher activity in managing learning was very good, student activity during the learning process was also very good, and the test results showed that 81.25% of students were included in the high numeracy literacy ability category. Thus, it can be concluded that differentiated learning with the support of ethnomathematics-based LKPD is effective in improving students' numeracy literacy skills.
ANALYSIS OF THE CAUSES AND IMPACTS OF DIVORCE IN WONOGIRI REGENCY CENTRAL JAVA PROVINCE
Authors: Hutasoit Imelda , Gandhi Wali Mahendra , Simanullang Welly Pratama , Huka Adrianus Louse , Maromon Yansen Alther
Published: December 2024

Family resilience is a very important aspect in supporting development, but changes in habits and social values ​​make the divorce rate higher, which has various negative impacts, especially on the lives of children. The aim of this research is to describe and analyze the picture of divorce, the causes and impacts of divorce in Wonogiri Regency. The research method used is descriptive qualitative. Data collection techniques used interviews and documentation. The data analysis technique uses several stages, namely preparing the data, reading all the data, presenting the data, coding or organizing the data, analyzing the data, describing the data that has been analyzed, and interpreting the data or drawing conclusions. The research results illustrate that divorce cases fluctuate, but the number is very high. Complaint divorce or divorce at the wife's request is the highest and shows more than three times the number compared to talak divorce or divorce at the husband's request. The causes of divorce include problems in family communication, economic problems, feelings of jealousy, feelings of superiority, infidelity, domestic violence (KDRT) and the rise of early marriage. Regarding the impact, divorce in Wonogiri Regency has an impact on various parties, namely children, divorced couples and extended families. Efforts to overcome divorce can be carried out by providing outreach to teenagers to avoid promiscuity, providing pre-marital education so that they can maintain the integrity of the household, and by improving the quality of human resources officers so that reporting cases of violence can be done quickly and accurately.
Bilgi Sistemleri Özelinde Bütünsel Dijital Dönüşüm: Teknoloji ve Ekosistem İhtiyaçlarının Dengelenmesi
Authors: Akbulut Müge
Published: December 2024

Dijital dönüşüm, bilgi ve iletişim teknolojilerini kullanarak verimli ve sürdürülebilir çözümler geliştirmeyi amaçlayan kapsamlı bir süreçtir. Ancak bu dönüşüm sadece yeni teknolojilere yatırım yapmakla sınırlı kalmamalıdır. Başarılı bir dijital dönüşüm için mevcut ekosistemin dinamikleri ve ihtiyaçları da dikkate alınarak bütüncül bir yaklaşımla ilerlemek gerekir. Aksi takdirde yeni platformlar beklenen başarıyı sağlayamaz ve dönüşüm çabaları başarısızlıkla sonuçlanabilir. Bu bağlamda, Adner ve Kapoor’un teknoloji-ekosistem modeli, teknolojik değişimlerin ekosistem dinamikleri ile nasıl etkileşime girdiğini anlamak için güçlü bir çerçeve sunmaktadır. Bu çalışmada, Adner ve Kapoor'un modeli bilgi sistemleri bağlamında incelenmiştir. Dijital dönüşüm sürecinde ekosistemin önemini vurgulayan bu çalışma, yalnızca teknolojiye değil, aynı zamanda destekleyici ekosisteme de odaklanmanın gerekliliğini örneklerle açıklamaktadır. Ayrıca, ekosistem yaratma aşamasında teknolojinin mevcut ekosistem ile uyumu, bağımsızlık ihtiyacı, hedef kitle, farklı kullanım özellikleri ve kullanıcı dostu bir arayüz gibi faktörlerin de göz önünde bulundurulması gerektiğine değinilmiştir. Çalışmanın sonuçları, yeni teknolojilerin mevcut ekosistemlerle uyum sağlamasının benimsenme sürecini hızlandırdığını ve sürdürülebilirliği sağladığını ortaya koymaktadır. Pratik uygulamalar arasında, stratejik planlama, entegrasyonun iyileştirilmesi ve kullanıcı adaptasyonu yer almakta olup, bu unsurlar uzun vadeli dijital dönüşüm hedeflerine ulaşmak için kritik öneme sahiptir.
Peran Mudir dalam Menanamkan Moderasi Beragama Demi Mencegah Tindak Terorisme di Lingkungan Pesantren Mustahafawiyah Mandailing Natal
Authors: Arianto Nanang , Datuk Imam Marzuki  , Susanti Hasibuan  , Desiana
Published: December 2024

Mudir is actually the highest leader in the Islamic boarding school and is an icon of the Islamic boarding school itself.  The mudir must be at the forefront and be the spearhead of the Islamic boarding school's progress. Mudir must also play a role in preventing the flow of radicalism from spreading within the Musthafawiyah Islamic boarding school.  And currently H. Mustafa Bakri Nasution is believed to be the mudir of the Musthafawiyah Islamic boarding school who has a very important role in maintaining the ideological traditions of the Musthafawiyah Islamic boarding school. The aim of this research is to see the role of H. Mustafa Bakri Nasution as the mudir of the Musthafawiyah Islamic boarding school in preventing radicalism from targeting its students, and how the mudir's efforts to implement the ideology of religious moderation within the Musthafawiyah Islamic boarding school environment. The purpose of this study is to see how the role of H. Mustafa Bakri Nasution as the head of the Musthafawiyah Islamic boarding school in preventing radicalism that targets his students, and how the head's efforts to implement religious moderation in the Musthafawiyah Islamic boarding school environment. This study uses a qualitative methodology by making students, educators and the head as data collection instruments and using descriptive as a technique for describing it. The results of this study indicate that the role of the head of the Musthafawiyah Islamic boarding school in preventing the entry of radicalism is by controlling the curriculum to comply with the Ministry of Education and Technology and controlling the quality of ustadz/ustadzah as educators at the Islamic boarding school. In addition, the head is selective about thoughts that come from outside, and collaborates with parties who contribute to bringing Islamic thought that develops in accordance with Islamic teachings that have become a traditional ideology in the Mustafawiyah Islamic boarding school environment.
Breakthrough in cancer diagnosis: the role of non-invasive biomarkers and mced tests compared to conventional method
Authors: Mustafa Samavia , Ghaffar Maliha , Waheed Atifa , Abbas Anam , Khan Sana , Mehar Ayesha , Masood Beenish
Published: December 2024

The uncontrolled cell division is known as cancer and it is responsible for approximately 19.3 million new cases and 10 million deaths in 2020 as reported by WHO (World Health Organization). Timely cancer detection is essential for patient health improvement and reducing mortality rate. Traditional methods for diagnosing cancer often rely on invasive techniques or lack sensitivity for pre-symptomatic stages. A recent breakthrough study has presented a potentially game-changing paradigm shift in the form of the blood test with the help of blood-based biomarkers, which tells about the disease before its traditional detection around four years before and it also claims to detect five common cancers (stomach, esophageal, colorectal, lung, and liver). Non-invasive biomarkers, including circulating tumor DNA (ctDNA), circulating tumor cells (CTCs), micro ribonucleic acid RNAs (miRNAs), circulating cell-free DNA (cfDNA), circulating carcinoma proteins, DNA methylated regions, and tumor-derived exosomes (TDEs), represent significant progress in cancer diagnostics. These biomarkers, derived from bodily fluids, provide a promising avenue for detecting cancers in their early stages, potentially reducing mortality rates. PanSeer is another type of blood testing that targets DNA methylation in circulating tumor DNA (ctDNA). It is effective in detecting five common cancers at an early stage, with a sensitivity of 90% and a specificity of 99%. The study is still ongoing, but the results so far are promising. If PanSeer and blood-based detection are validated in larger studies, they could become a valuable tool for early cancer detection. Liquid biopsies are safer, simpler, and more effective for early and real-time cancer detection compared to traditional methods which can be painful and carry risks of complications such as infection or delay healing. Advancements in sequencing techniques offer promise, with whole-genome bisulfite sequencing, microarray-based sequencing, and digital polymerase chain reaction (PCR-based) assays enhancing methylome profiling. Moreover, the absence of official Food and Drug Administration (FDA) approval for MCD (Multi-Cancer Detection) tests underscores the need for comprehensive clinical benefit evaluation, distinct from traditional drug approval processes that require collaborative efforts, transparency, and continuous assessment
Um mercado de ruídos e sons para o bem-estar
Authors: Andrade Pereira Vinícius , De Borba Lucas Cássio
Published: December 2024

Este artigo faz a conjectura de um mercado emergente na paisagem comunicacional e aural contemporânea, um Mercado de Ruídos e Sons para o Bem-Estar (MERSBE). Tal mercado seria caracterizado por produtos ruidosos com sonoridades singulares que visam a diferentes formas de bem-estar: de melhoria física e psíquica, como o aprimoramento da memória, da concentração, da qualidade do sono, ao foco em atividades de estudo e trabalho, além de diversas formas de prazer, como os “orgasmos cerebrais”, relatados por consumidores de ASMR. A MERSBE revelaria, ainda, como a cultura contemporânea se abre para novos modos de relacionamento com aquilo que a teoria da comunicação condenou como sua parte espúria: os ruídos. Passando de uma posição provocativa – como era o caso no Manifesto Futurista de Russolo, na Música Concreta e na noise music – e chegando à comoditização em mercado sônico global, os ruídos estão sendo docilizados como experiências terapêuticas.
Device topology optimization for an inerter-based structural dynamic vibration absorber
Authors: Xie Ruihong , Ikago Kohju
Published: December 2024

A tuned viscous mass damper (TVMD) and a tuned inerter damper (TID) have been proposed as devices that can achieve weight reduction by replacing the mass element of a structural dynamic vibration absorber (DVA) with an inerter. In the TID, the damping element is arranged in parallel with the spring, making its device topology the same as conventional dynamic vibration absorbers. In contrast, in the TVMD the damping element is arranged in parallel with the inerter. This parallel mechanism of inerter and damping element can be realized in a single device, and the member of the building that supports the device can be used as the spring element, making the TVMD highly practical. In fact, TVMDs with a mass effect equivalent to thousands of tons have been commercialized and applied to high-rise buildings in Japan. This paper aims to clarify the effects of the choice of objective functions and damping element arrangement on the seismic response control effectiveness of inerter-based structural DVAs, providing guidelines for structural engineers in selecting suitable devices to achieve desired control effects. The method of investigation considers a model that encompasses both TVMD and TID configurations and formulates a multi-objective optimization problem to simultaneously minimize the displacement amplification factor and floor response acceleration amplification factor. The results of the multi-objective optimization reveal that the TVMD is optimal when the focus is on controlling displacement response, while the TID is optimal when prioritizing the control of floor response acceleration. It was found that the floor response acceleration amplification factor of a structure containing TVMD could be significantly improved by slightly compromising the displacement response amplification factor, leading to the recommendation of adopting the TVMD configuration as an inerter-based structural DVA.
Behavioral and biomedical factors associated with lifestyle modification practices among diagnosed hypertensive patients in pastoral health facilities of southern Ethiopia
Authors: Yakob Tagese , Yakob Begidu , Jaldo Mesfin Menza , Dawit Desalegn , Elias Chernet , Israel Eskinder , Abraham Awoke
Published: December 2024

Background

More than 23 million deaths and 36.5% of disability-adjusted life-years are the result of the direct effects of unhealthy behavior alone. Daily behaviors have strong implications for health outcomes and quality of life. The aim of this study is to determine the behavioral and biomedical factors associated with lifestyle modification practices among diagnosed hypertensive patients in pastoral health facilities of southern Ethiopia.

Methods

A facility-based cross-sectional study was conducted among 453 diagnosed hypertensive adult patients in pastoral health of southern Ethiopia from June 1/2023 to July 30/2023. The study population was randomly selected from among patients diagnosed with hypertension that was followed up during the study period using a systematic random sampling technique. The data were entered into Epi-Data-4.6.0.2 and exported to SATAT version 14 for analysis. A binary logistic regression model was fitted to determine independent predictors of lifestyle modification practices among hypertensive patients. An adjusted odds ratio with a 95% confidence interval was used to declare a state of significance.

Results

Out of 453 potential participants approached, 433 agreed to successfully participate in the study, for a response rate of 95.6%. Of the total participants, 56.1% (95% CI, 51.38–60.74) of the patients practiced the recommended lifestyle modifications. Alcohol consumption (AOR = 0.64, 95% CI: 0.42–0.96), ever-practiced reducing salt intake (AOR = 2.48, 95% CI: 1.57–3.93), and low-density lipoprotein cholesterol levels in the blood (>160 mg/dl) (AOR = 3.3, 95% CI: 1.72–6.34) were independently associated with lifestyle modifications in patients with hypertension.

Conclusion

This study revealed that the prevalence of lifestyle modification practices (LMP) was low among hypertensive patients. Lifestyle modification is not one-stop practical, but continuous proper awareness creation, counseling, and health education and health promotion are needed to scale up healthy behavior in patients with hypertension to create a good lifestyle.
Optical remote spectral acquisition of elemental stoichiometry
Authors: Reeves Jamie T. , Hasnain Sarah S. , Nessel Mark P. , Talbot Ceara J. , Thomson Eleanor R.
Published: December 2024

Optical remote sensing (RS) enables the study of the elemental composition of Earth’s surface over broad spatial extents by detecting reflected electromagnetic radiation. Covalent bonds of macromolecular structures often reflect electromagnetic radiation at specific wavelengths, and in some cases relate to bonds of specific elemental identity. In other cases, interfering optical properties greatly impact the ability of RS to measure elements directly, but advances in statistical methods and the theoretical understanding of optical properties expand the capacity to quantify diverse elements in many systems. When applied under the framework of ecological stoichiometry, spatially and temporally explicit measurements of elemental composition permit understanding of the drivers of ecological processes and variation over space and through time. However, the multitude of available technologies and techniques present a large barrier of entry into RS. In this paper we summarize the capabilities and limitations of RS to quantify elements in terrestrial and aquatic systems. We provide a practical guide for researchers interested in using RS to quantify elemental ratios and discuss RS as an emerging tool in ecological stoichiometry. Finally, we pose a set of emerging questions which integrating RS and ecological stoichiometry is uniquely poised to address.
Urinary TYROBP and HCK as genetic biomarkers for non-invasive diagnosis and therapeutic targeting in IgA nephropathy
Authors: Xie Boji , Pang Shuting , Xie Yuli , Tan Qiuyan , Li Shanshan , Jili Mujia , Huang Yian , Zhao Binran , Yuan Hao , Mi Junhao , Chen Xuesong , Ruan Liangping , Chen Hong , Li Xiaolai , Hu Boning , Huang Jing , Yang Rirong , Li Wei
Published: December 2024

Background

IgA nephropathy (IgAN) is a leading cause of renal failure, but its pathogenesis remains unclear, complicating diagnosis and treatment. The invasive nature of renal biopsy highlights the need for non-invasive diagnostic biomarkers. Bulk RNA sequencing (RNA-seq) of urine offers a promising approach for identifying molecular changes relevant to IgAN.

Methods

We performed bulk RNA-seq on 53 urine samples from 11 untreated IgAN patients and 11 healthy controls, integrating these data with public renal RNA-seq, microarray, and scRNA-seq datasets. Machine learning was used to identify key differentially expressed genes, with protein expression validated by immunohistochemistry (IHC) and drug-target interactions explored via molecular docking.

Results

Urine RNA-seq analysis revealed differential expression profiles, from which TYROBP and HCK were identified as key biomarkers using machine learning. These biomarkers were validated in both a test cohort and an external validation cohort, demonstrating strong predictive accuracy. scRNA-seq confirmed their cell-specific expression patterns, correlating with renal function metrics such as GFR and serum creatinine. IHC further validated protein expression, and molecular docking suggested potential therapeutic interactions with IgAN treatments.

Conclusion

TYROBP and HCK are promising non-invasive urinary biomarkers for IgAN. Their predictive accuracy, validated through machine learning, along with IHC confirmation and molecular docking insights, supports their potential for both diagnostic and therapeutic applications in IgAN.
Anti-CD4 monoclonal antibody prevents chronic graft-versus-host disease in mice by inducing immune tolerance of CD8+ T cells and alleviating thymus injury
Authors: Wang Ziwei , Li Ruiqi , Fu Weijia , Cheng Hui , Zhang Yan , Tang Gusheng , Yang Jianmin , Wang Jianmin , Ni Xiong
Published: December 2024

Background

Chronic graft-versus-host disease (cGVHD) manifests with characteristics of autoimmune disease with organs attacked by pathogenic helper T cells. Recent studies have highlighted the role of T cells in cGVHD pathogenesis. Due to limited understanding of underlying mechanisms, preventing cGVHD after allogenic hematopoietic cell transplantation (HCT) has become a major challenge.

Materials and methods

Here, we used a representative cGVHD model with the donor C57BL/6 to recipient BALB/c combination. Post-HCT, mice were treated with IgG or anti-CD4 monoclonal antibody. The severity of cGVHD was assessed by evaluating symptoms of cGVHD and histopathology examination (H&E) of target organs. Thymus gland damage and defects of the negative selection were assessed by analyzing the CD4+CD8+ double-positive thymocytes, cortical thymic epithelial cells and medullary thymic epithelial cells (mTECs). Immunotolerance of CD8+ T cells was assessed by detecting the expression of CD80, PD-1, GRAIL and IL-7Rα. Long-term cellular and humoral immunity associated with graft-versus-leukemia (GVL) effects were evaluated through detecting the percentage of CD4+ T cells, IgG, IgM and IgA concentrations, and performing tumor challenge experiment.

Results

Donor CD8+ T cells caused thymic epithelial cells damage and impaired negative selection in recipients, leading to generation of autoreactive T cells and causing cGVHD. Anti-CD4 mAb treatment promoted immune incompetence of thymus-infiltrating CD8+ T cells, facilitated recovery of CD4+CD8+ thymocytes and regeneration mTECs, and preserved negative-selection, but had no effects on the long-term cellular immunity and humoral immunity, resulting in preservation of GVL effect.

Conclusion

Our results indicate that anti-CD4 mAb therapy early post-HCT allows thymus recovery by inducing the immune tolerance of thymus infiltrated CD8+ T cells, thereby alleviating thymic epithelial cells damage, preserving negative selection, and preserving long-term GVL effect at the same time.
Missing the mark(ers): circulating endothelial cells and endothelial-derived extracellular vesicles are elevated in sickle cell disease plasma
Authors: Beckman Joan D. , Zhang Ping , Nguyen Julia , Hebbel Robert P. , Vercellotti Gregory M. , Belcher John D.
Published: December 2024

Sickle cell disease (SCD) is a devastating hemolytic disease, marked by recurring bouts of painful vaso-occlusion, leading to tissue damage from ischemia/reperfusion pathophysiology. Central to this process are oxidative stress, endothelial cell activation, inflammation, and vascular dysfunction. The endothelium exhibits a pro-inflammatory, pro-coagulant, and enhanced permeability phenotype. We used flow cytometry to enumerate circulating endothelial cells (CECs, CD31+/CD45-/CD146+) in SCD and normal healthy control blood samples. Furthermore, we assessed CEC subtypes, including circulating endothelial progenitor cells (EPCs, CD31+/CD45-/CD146+/CD133+) and mature CECs (mCECs, CD31+/CD45-/CD146+/CD133-) with mCECs further subdivided into resting CECs (rCECs, VCAM-1-) and activated CECs (aCECs, VCAM-1+). As compared to healthy controls, total CECs and mCECs were elevated in SCD blood as compared to healthy control blood. Using the same markers along with size-based gating, we also used flow cytometry to enumerate endothelial-derived extracellular vesicles (EEVs) in plasma. We assessed EEV subtypes based on VCAM-1 expression, including activated EEVs (aEEVs, CD31+/CD45-/CD146+/CD133-/VCAM-1+) and resting EEVs (rEEVs, VCAM-1 negative), presumably derived from activated and resting endothelial cells, respectively. aEEVs were elevated in SCD patient plasma as compared to healthy controls. Importantly, in SCD patients, total EEVs and aEEVs were increased during self-reported pain crisis as compared to steady state. Plasma markers of endothelial cell activation including soluble E-selectin, P-selectin, VCAM-1, and ICAM-1 were elevated in SCD plasma. These data highlight strategies to detect SCD-related endothelial cell activation and demonstrate that endothelial cell activation markers may be useful to evaluate curative and non-curative therapies in SCD patients.