bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and assistive technology: a tinder match waiting to happen
Authors: Phillips Hana , Renda Gianni , McDonald Rachael
Published: February 2024

Assistive technology (AT) is any artefact that enables participation in activities usually limited by disability. Frequently, AT suffers from poor design engagement and utilisation. Moreover, up to 30% of all AT is abandoned within a year, negatively impacting users. This presents an ongoing challenge for occupational therapists (OTs) who work with assistive technologies. A literature review was conducted using a Preferred Reporting Items for Systematic Reviews and Meta-Analysis protocol to understand this issue and its implications for the design community. This study explores current themes of AT abandonment and the role of OT within the lens of design thinking. Studies, including design intervention in AT, were subsequently highlighted. This led to comparing this literature with more traditional health literature, exploring the potential enablers and barriers for design in engaging with AT. This evidenced the benefits of collaboration between design and OT disciplines to improve the product and reduce abandonment issues.
Local-global compatibility for regular algebraic cuspidal automorphic representations when
Authors: Varma Ila
Published: February 2024

We prove the compatibility of local and global Langlands correspondences for

$\operatorname {GL}_n$

up to semisimplification for the Galois representations constructed by Harris-Lan-Taylor-Thorne [10] and Scholze [18]. More precisely, let

$r_p(\pi )$

denote an n-dimensional p-adic representation of the Galois group of a CM field F attached to a regular algebraic cuspidal automorphic representation

$\pi $

of

$\operatorname {GL}_n(\mathbb {A}_F)$

. We show that the restriction of

$r_p(\pi )$

to the decomposition group of a place

$v\nmid p$

of F corresponds up to semisimplification to

$\operatorname {rec}(\pi _v)$

, the image of

$\pi _v$

under the local Langlands correspondence. Furthermore, we can show that the monodromy of the associated Weil-Deligne representation of

$\left .r_p(\pi )\right |{}_{\operatorname {Gal}_{F_v}}$

is ‘more nilpotent’ than the monodromy of

$\operatorname {rec}(\pi _v)$

.
A continuous-wave Nd:YVO
4
-KGW intracavity Raman laser with over 34% diode-to-Stokes optical efficiency
Authors: Sheng Quan , Geng Jingni , Liu Tianchang , Fu Shijie , Shi Wei , Yao Jianquan
Published: February 2024

We demonstrate a continuous-wave (CW) Nd:YVO4-potassium gadolinium tungstate (KGW) intracavity Raman laser with a diode-to-Stokes optical efficiency of 34.2%. By optimizing the cavity arrangement and reducing the cavity losses, 8.47 W Stokes output at 1177 nm was obtained under an incident 878.6 nm diode pump power of 24.8 W. The influence of cavity losses on the power and efficiency of the CW Raman laser, as well as the potential for further optimization, was investigated based on the numerical model. The observation of thermally-induced output rollover was well explained by the calculation of the thermal lensing and cavity stability, indicating that the end-face curvature played an important role when the end-face of the crystal was highly reflective coated to make the cavity. A 10.9 W Stokes output under 40.9 W incident pump was also demonstrated with a cavity arrangement less sensitive to the end-face curvature, which is the highest output power of CW intracavity Raman lasers reported.
Genomic investigation of multispecies and multivariant blaNDM outbreak reveals key role of horizontal plasmid transmission
Authors: Macesic Nenad , Dennis Adelaide , Hawkey Jane , Vezina Ben , Wisniewski Jessica A. , Cottingham Hugh , Blakeway Luke V. , Harshegyi Taylor , Pragastis Katherine , Badoordeen Gnei Zweena , Bass Pauline , Stewardson Andrew J. , Dennison Amanda , Spelman Denis W. , Jenney Adam W.J. , Peleg Anton Y.
Published: February 2024

Objectives:

New Delhi metallo-β-lactamases (NDMs) are major contributors to the spread of carbapenem resistance globally. In Australia, NDMs were previously associated with international travel, but from 2019 we noted increasing incidence of NDM-positive clinical isolates. We investigated the clinical and genomic epidemiology of NDM carriage at a tertiary-care Australian hospital from 2016 to 2021.

Methods:

We identified 49 patients with 84 NDM-carrying isolates in an institutional database, and we collected clinical data from electronic medical record. Short- and long-read whole genome sequencing was performed on all isolates. Completed genome assemblies were used to assess the genetic setting of blaNDM genes and to compare NDM plasmids.

Results:

Of 49 patients, 38 (78%) were identified in 2019–2021 and only 11 (29%) of 38 reported prior travel, compared with 9 (82%) of 11 in 2016–2018 (P = .037). In patients with NDM infection, the crude 7-day mortality rate was 0% and the 30-day mortality rate was 14% (2 of 14 patients). NDMs were noted in 41 bacterial strains (ie, species and sequence type combinations). Across 13 plasmid groups, 4 NDM variants were detected: blaNDM-1, blaNDM-4, blaNDM-5, and blaNDM-7. We noted a change from a diverse NDM plasmid repertoire in 2016–2018 to the emergence of conserved blaNDM-1 IncN and blaNDM-7 IncX3 epidemic plasmids, with interstrain spread in 2019–2021. These plasmids were noted in 19 (50%) of 38 patients and 35 (51%) of 68 genomes in 2019–2021.

Conclusions:

Increased NDM case numbers were due to local circulation of 2 epidemic plasmids with extensive interstrain transfer. Our findings underscore the challenges of outbreak detection when horizontal transmission of plasmids is the primary mode of spread.
The impact of experience on the tendency to accept recommended defaults
Authors: Roth Yefim , Waldman Greta Maayan , Erev Ido
Published: February 2024

Two preregistered web studies are presented that explore the impact of experience on the tendency to accept recommended defaults. In each of the 100 trials, participants (n = 180, n = 165) could accept a recommended default option or choose a less attractive prospect. The location of the options (left or right) was randomly determined before each trial. Both studies compared two conditions. Under Condition Dominant, the default option maximized participants’ payoff in all trials. Under Condition Protective, the default option protected the participants from rare losses and maximized expected return but decreased payoff in most trials. The results reveal a tendency to accept the default in Condition Dominant but the opposite tendency in Condition Protective. This pattern was predicted by assuming that in addition to promoting specific actions, the presentation of the default changes the set of feasible strategies, and choice between these strategies reflects reliance on small samples of past experiences.
Uncertainties about waste using an online survey and review approach: Environmentalist perceptions, household waste compositions and views from media and science
Authors: Markley Laura A. T. , Grünzner Maja , Walker Tony R.
Published: February 2024

Waste generation and subsequent plastic pollution pose a major threat to both human and environmental health. Furthering our understanding of waste at individual levels can inform future waste reduction strategies, education and policies. This study explores the components and perceptions among individuals using survey data combined with a mini-review. An online Qualtrics survey was distributed pre-COVID-19 following a global social media challenge, Futuristic February, which directed participants to collect their nonperishable waste during February 2020. Participants were asked about their waste generation, perceptions toward waste and plastic pollution issues, and environmental worldview using the New Ecological Paradigm (NEP) scale (n = 50). We also conducted a mini-review of eight waste and plastic pollution statements from our survey in both popular media and scientific journal articles. Survey results indicated participants had an overall pro-ecological worldview (M = 4.32, SD = 0.88) and reported cardboard and paper (66%) as the most commonly occurring nonperishable waste category. Across categories, food packaging was the most common waste type. Participants were most uncertain about statements focusing on bioplastic or biodegradable plastic, respectively (44% and 30%), while the statement on microplastic toxicity obtained 100% mild or strong agreement among participants. Uncertainty for reviewed statements varied depending on the topic and group. Popular media and scholarly articles did not always agree, possibly due to differences in communication of uncertainty or terminology definitions. These results can inform future policy and educational campaigns around topics of misinformation.
Dietary factors and the risk of atopic dermatitis: a Mendelian randomisation study
Authors: Che Yuhui , Yuan Jinyao , Wang Qian , Liu Mengsong , Tang Dadong , Chen Mulan , Xiao Xinyu , Pang Yaobin , Chen Siyan , Han Wen , Xiao Zhiyong , Zeng Jinhao , Guo Jing
Published: February 2024

Previous studies have revealed an association between dietary factors and atopic dermatitis (AD). To explore whether there was a causal relationship between diet and AD, we performed Mendelian randomisation (MR) analysis. The dataset of twenty-one dietary factors was obtained from UK Biobank. The dataset for AD was obtained from the publicly available FinnGen consortium. The main research method was the inverse-variance weighting method, which was supplemented by MR‒Egger, weighted median and weighted mode. In addition, sensitivity analysis was performed to ensure the accuracy of the results. The study revealed that beef intake (OR = 0·351; 95 % CI 0·145, 0·847; P = 0·020) and white bread intake (OR = 0·141; 95 % CI 0·030, 0·656; P = 0·012) may be protective factors against AD. There were no causal relationships between AD and any other dietary intake factors. Sensitivity analysis showed that our results were reliable, and no heterogeneity or pleiotropy was found. Therefore, we believe that beef intake may be associated with a reduced risk of AD. Although white bread was significant in the IVW analysis, there was large uncertainty in the results given the wide 95 % CI. Other factors were not associated with AD in this study.
Book-to-Market, Mispricing, and the Cross Section of Corporate Bond Returns
Authors: Bartram Söhnke M. , Grinblatt Mark , Nozawa Yoshio
Published: February 2024

Corporate bonds’ book-to-market ratios predict returns computed from transaction prices. Senior bonds (even investment grade) with the 20% highest ratios outperform the 20% lowest by 3%–4% annually after non-parametrically controlling for numerous liquidity, default, microstructure, and priced-risk attributes: yield-to-maturity, bid–ask spread, duration/maturity, credit spread/rating, past returns, coupon, size, age, industry, and structural model equity hedges. Spreads for all-bond samples are larger. An efficient bond market would not exhibit the observed decay in the ratio’s predictive efficacy with implementation delays, small yield-to-maturity spreads, or similar-sized spreads across bonds with differing risks. A methodological innovation avoids liquidity filters and censorship that bias returns.
Financing Negative Shocks: Evidence from Hurricane Harvey
Authors: Collier Benjamin L. , Powell Lawrence S. , Ragin Marc A. , You Xuesong
Published: February 2024

We examine the effects of a severe climate event on local firms. Our data include 8,218 business credit reports and a detailed survey of 273 businesses in the area affected by Hurricane Harvey. Delinquent credit balances doubled in areas with the worst flooding, although nonflooded areas also had significant credit impairments. Only independent businesses showed signs of distress; subsidiaries of larger firms did not. Firms were largely uninsured and often were denied credit postdisaster. Many funded recovery informally, such as through friends and family. Our findings suggest that several financial frictions compound the challenges posed by a severe climate event.
Electromagnetic oscillations and anomalous ion scattering in the helically symmetric multiple-mirror trap
Authors: Tolkachev Mikhail S. , Inzhevatkina Anna A. , Sudnikov Anton V. , Chernoshtanov Ivan S.
Published: February 2024

The paper presents an investigation of the plasma fluctuation in the SMOLA helical mirror, which is suspected to be responsible for anomalous scattering. The helical mirror confinement is effective when the ion mean free path is equal to the helix pitch length. This condition can be satisfied in hot collisionless plasma only by anomalous scattering. The wave, which scatters the passing ions, is considered to receive energy from the trapped ions. The oscillations of the electric field in the helically symmetric plasma were observed in experiment. The oscillations have both regular highly correlated and chaotic components. The dependency of the regular component frequency on the Alfvén velocity is linear for

$V_{\rm A} < 2.8 \times 10^6\ \text {m}\ \text {s}^{-1}$

and constant for higher values. It is shown experimentally that the condition for the wave to be in phase resonance with the trapped ions is satisfied in a specific region of the plasma column for the highly correlated component. The amplitude of the chaotic component (up to

$3\ \text {V}\ \text {cm}^{-1}$

) is higher than the estimated electric field required for the ion scattering.
Identification of Philaster apodigitiformis in aquaculture and functional characterization of its β-PKA gene and expression analysis of infected Poecilia reticulata
Authors: Zhou Chunyu , Liu Lihui , Jiang Mingyue , Wang Li , Pan Xuming
Published: February 2024

Cyclic adenosine monophosphate (cAMP)-dependent protein kinase A (PKA) is a distinctive member of the serine–threonine protein AGC kinase family and an effective kinase for cAMP signal transduction. In recent years, scuticociliate has caused a lot of losses in domestic fishery farming, therefore, we have carried out morphological and molecular biological studies. In this study, diseased guppies (Poecilia reticulata) were collected from an ornamental fish market, and scuticociliate Philaster apodigitiformis Miao et al., 2009 was isolated. In our prior transcriptome sequencing research, we discovered significant expression of the β-PKA gene in P. apodigitiformis during its infection process, leading us to speculate its involvement in pathogenesis. A complete sequence of the β-PKA gene was cloned, and quantified by quantitative reverse transcription-polymerase chain reaction to analyse or to evaluate the functional characteristics of the β-PKA gene. Morphological identification and phylogenetic analysis based on small subunit rRNA sequence, infection experiments and haematoxylin–eosin staining method were also carried out, in order to study the pathological characteristics and infection mechanism of scuticociliate. The present results showed that: (1) our results revealed that β-PKA is a crucial gene involved in P. apodigitiformis infection in guppies, and the findings provide valuable insights for future studies on scuticociliatosis; (2) we characterized a complete gene, β-PKA, that is generally expressed in parasitic organisms during infection stage and (3) the present study indicates that PKA plays a critical role in scuticociliate when infection occurs by controlling essential steps such as cell growth, development and regulating the activity of the sensory body structures and the irritability system.
20-year neurocognitive development following a schizophrenia spectrum disorder and associations with symptom severity and functional outcomes
Authors: Starzer Marie , Hansen Helene Gjervig , Hjorthøj Carsten , Albert Nikolai , Lewandowski Kathryn E. , Glenthøj Louise Birkedal , Nordentoft Merete
Published: February 2024

Background

Cognitive deficits are a core feature of schizophrenia and are closely associated with poor functional outcomes. It remains unclear if cognitive deficits progress over time or remain stable. Determining patients at increased risk of progressive worsening might help targeted neurocognitive remediation approaches.

Methods

This 20-year follow-up study examined neurocognitive outcomes of 156 participants from the OPUS I trial. Neurocognition was assessed using the brief assessment of cognition in schizophrenia at the 10- and 20-year follow-up, allowing us to examine changes in neurocognition over ten years.

Results

We found that 30.5% of patients had a declining course of neurocognition, 49.2% had a stable course of neurocognition and 20.3% experienced improvements in neurocognition. Good cognitive functioning at the 20-year follow-up was significantly associated with higher levels of social functioning (B 6.86, CI 4.71–9.02, p < 0.001) while increasing experiential negative symptoms were significantly correlated to cognitive worsening (PC-0.231, p = 0.029). Younger age at inclusion (B: 0.23 per 10-years, CI 0.00–0.045, p = 0.047) and low level of education (below ten years) (mean difference: −0.346, CI −0.616 to −0.076, p = 0.012) predicted declining neurocognition.

Conclusion

Our findings support the notion of different schizophrenia subtypes with varying trajectories. Neurocognitive impairment at the 20-year follow-up was associated with other poor outcomes, highlighting the importance of treatments aimed at improving neurocognition in patients with schizophrenia spectrum disorders.
An argument for the perspectival account of faith
Authors: Tweedt Chris
Published: February 2024

Faith, I argue, is a value-oriented perspective, where the subject has a pro-attitude towards the object of the perspective. After summarizing the perspectival account of faith and its upshots that are relevant to the proceeding argument, I give an extended explanatory, cumulative case argument for the account by showing that the perspectival account of faith explains the data that alternative accounts of faith seek to explain, including why faith is present in paradigmatic cases of faith and the truth, or perceived truth, of various statements about faith. In addition, I argue that the perspectival account of faith explains the plausibility of alternative accounts of faith; each of the alternative accounts of faith focuses on a feature or consequence of faith, according to the perspectival account, which we would expect if other faith theorists seek but incorrectly identify the correct account of faith.
Reinforcement learning-based motion control for snake robots in complex environments
Authors: Zhang Dong , Ju Renjie , Cao Zhengcai
Published: February 2024

Snake robots can move flexibly due to their special bodies and gaits. However, it is difficult to plan their motion in multi-obstacle environments due to their complex models. To solve this problem, this work investigates a reinforcement learning-based motion planning method. To plan feasible paths, together with a modified deep Q-learning algorithm, a Floyd-moving average algorithm is proposed to ensure smoothness and adaptability of paths for snake robots’ passing. An improved path integral algorithm is used to work out gait parameters to control snake robots to move along the planned paths. To speed up the training of parameters, a strategy combining serial training, parallel training, and experience replaying modules is designed. Moreover, we have designed a motion planning framework consists of path planning, path smoothing, and motion planning. Various simulations are conducted to validate the effectiveness of the proposed algorithms.
Abolitionist Decrees in Ethiopia: The Evolution of Anti-Slavery Legal Strategies from Menilek to Haile Selassie, 1889–1942
Authors: Merid Takele , Meckelburg Alexander
Published: February 2024

Slavery and the slave trade were fundamental institutions in Ethiopian history. Their abolition was a protracted process that involved developing, debating, passing, and applying multiple anti-slavery and anti-slave trade edicts and decrees under successive rulers. While slavery existed in various societies that were later integrated in the Abyssinian empire since the second half of the nineteenth century and took different forms based on different legal traditions, this article focuses specifically on the Christian kingdom and its successor empire. It analyzes changes and continuities in legal approaches to slavery and its suppression through consecutive Ethiopian governments starting with a discussion of slavery's regulation in the ancient Christian law code, the Fetha nagast (“The Law of the Kings”). The article then considers how successive Christian emperors developed anti-slavery policies in response to both local and global dynamics.
Adolescent psychopathic traits and adverse environments: Associations with socially adaptive outcomes
Authors: Brazil Kristopher J. , Farrell Ann H. , Boer Abby , Volk Anthony A.
Published: February 2024

Researchers have suggested that psychopathic traits among adults may be, at least in part, an adaptive and/or a learned response for securing socially adaptive outcomes in adverse environments, but there is a lack of developmental evidence supporting this hypothesis among adolescents. Therefore, we examined the indirect links from self-perceived adverse environments (parental neglect, socioeconomic status, school competition, neighborhood violence) to evolutionarily relevant social outcomes (social power, dating behavior) through psychopathic traits. A community sample of 396 adolescents completed measures for the study (Mage = 14.64, SD = 1.52). As predicted, there were significant indirect effects from higher levels of parental neglect, school competition, and neighborhood violence to both forms of socially adaptive outcomes through psychopathic traits, but unexpectedly, there were no indirect effects with socioeconomic status. There were also direct effects between environment and socially adaptive outcomes. Results support the hypothesis that psychopathic traits may be, in part, an adaptive and/or learned response to cues from adverse social environments as a means to acquire evolutionarily relevant social outcomes. Interventions could be designed to target the adverse social issues that might be facilitating the development of psychopathy and should be sensitive to the social outcomes adolescents may acquire from these traits.
The turnpike property for mean-field optimal control problems
Authors: Gugat Martin , Herty Michael , Segala Chiara
Published: February 2024

We study the turnpike phenomenon for optimal control problems with mean-field dynamics that are obtained as the limit
$N\rightarrow \infty$
of systems governed by a large number
$N$
of ordinary differential equations. We show that the optimal control problems with large time horizons give rise to a turnpike structure of the optimal state and the optimal control. For the proof, we use the fact that the turnpike structure for the problems on the level of ordinary differential equations is preserved under the corresponding mean-field limit.
LES ŠĪʿITES DANS LES MAQĀLĀT D'AL-BALḪĪ ET AL-AŠʿARĪ: TRANSMISSIONS TEXTUELLES ET ENJEUX HISTORIOGRAPHIQUES
Authors: Kechavarzi Dariouche
Published: February 2024

La récente parution de l’édition complète des Maqālāt ahl al-qibla d'Abū l-Qāsim al-Balḫī (m. 319/931) ouvre de nouvelles perspectives sur l'histoire de la construction de la tradition doxographique musulmane. À travers une comparaison des Maqālāt d’al-Balḫī et des Maqālāt al-islāmiyyīn wa-ḫtilāf al-muṣallīn d’Abū l-Ḥasan al-Ašʿarī (m. 324/935-6), cet article démontre qu'al-Balḫī est la source directe d'al-Ašʿarī sur les šīʿites. Cette nouvelle donnée permet dès lors d'analyser l’évolution du genre des maqālāt aux IIIe/IXe-IVe/Xe siècles, notamment son rapprochement progressif avec une pratique spécifiquement hérésiographique.
AVERROES’ “EPISTLE ON DIVINE KNOWLEDGE” AS A DIALECTICAL WORK: BETWEEN FORBIDDEN INTERPRETATION AND PHILOSOPHICAL TRAINING
Authors: Halper Yehuda
Published: February 2024

Averroes’ “Epistle on Divine Knowledge” presents four different dialogues on two textual levels. These dialogues, the syllogistic structure of the arguments in them, and their use of contradictories indicate that the “Epistle on Divine Knowledge” is structured nearly entirely in accordance with the descriptions of dialectic we find in Averroes’ commentaries on Aristotle's Topica. Accordingly, Averroes’ solution to the question of how God can have universal knowledge of particular things is a dialectical account of the distinction between Divine and human knowledge. Moreover, at a crucial point in the “Epistle on Divine Knowledge” Averroes refers to Aristotle, Metaphysics Β, which he considers to a dialectical exposition of questions on metaphysics. This reference suggests that Averroes sees the “Epistle on Divine Knowledge” as a kind of dialectical inquiry aimed at answering questions that arise at the outset of studying metaphysics. So, while it is possible to view the “Epistle on Divine Knowledge” as a dialectical interpretation of Quran 67:14, its primary purpose is to introduce its readers to metaphysical speculation. Thus it does not violate Averroes’ legal prohibition given in the Decisive Treatise against declaring dialectical interpretations in books available to the general public.
Credit networks and business dynamics in a viceregal capital: Santafé de Bogotá in the age of Charles III
Authors: Granados Oscar M. , Torres James V.
Published: February 2024

This article provides aggregate data on credit flows in Santafé de Bogotá, the capital of the Viceroyalty of New Granada (present-day Colombia, Ecuador and western Venezuela). By perusing a thorough report submitted to Bourbon authorities on notarial transactions, which included both ecclesiastical and non-ecclesiastical loans in the city, the article estimates the volume and size of lending activity while exploring how distinct types of credit interacted and shaped the business milieu of the region. It argues that by the late 1770s, Catholic Church lending had ceased to be the main source of investable funds in the region, with merchants and other non-ecclesiastical investors injecting growing funds into sectors traditionally avoided by ecclesiastical lenders such as commerce, mining and manufacturing. Network analysis suggests that merchants became brokers between different credit sources, alleviating information asymmetries and opening the credit market to borrowers with collateral and institutional restrictions willing to pay higher interest rates. Finally, by focusing on New Granada, the largest gold producer of the Spanish Empire, the article identifies some distinctive credit patterns that are different from those developed in silver-driven economies such as New Spain and Peru. Thus, the article provides new paths to study Latin American financial history.
REMEMBRANCES OF A TREASURER: 1999–2015
Authors: Niman Neil B.
Published: February 2024

I began as the secretary/treasurer for the History of Economics Society (HES) in 1999. Prior to my appointment, I had attended one conference and really didn’t know much about the society. My colleague Jim Wible (who was an active member) asked me if I would be interested and essentially pushed my name forward (there probably were not any other takers at the time). I was handed a paper ledger, a notebook of minutes, another collection of materials that were passed down from president to president, and $50,000 in bank deposits.
ÉMIGRÉ ECONOMISTS IN AMERICA: THEIR IMPACT AND THEIR EXPERIENCES
Authors: Hagemann Harald
Published: February 2024

I first visited the United States in September 1980 when I spent two weeks at the New School for Social Research in New York. The main reason was the first personal meeting with Adolph Lowe (1893–1995), with whom I had been in close contact since spring 1977 when I got my PhD in economics from the University of Kiel. Lowe had built up a new department for research on business cycles and international statistical economics at the Kiel Institute of World Economics since April 1926, which soon acquired an international reputation (Hagemann 2021). The group included such outstanding economists as Gerhard Colm, Hans Neisser, Fritz (Frank) Burchardt, and for some years also Wassily Leontief and Jacob Marschak. None of them remained in Germany after the Nazis’ rise to power in 1933. Lowe had moved to the Goethe University in Frankfurt in October 1931, where he was dismissed after three semesters. Like many other émigré economists, he first went to Great Britain (Hagemann 2007), where he became an honorary lecturer in economics and political philosophy at the University of Manchester. In summer 1940 he moved further to New York where the Graduate Faculty of the New School had been founded as the “University in Exile” by Alvin Johnson, and Emil Lederer became the founding dean in 1933.1 Thus, in contrast to Colm, Lowe, as well as his lifelong friend Marschak (both were supervisors of Franco Modigliani’s New School PhD thesis) and Neisser were not members of the Mayflower generation.
Influencing factors of knowledge proficiency of general practitioners in rural China for esophageal cancer prevention and treatment: a cross-sectional study
Authors: Zhang Jinjia , Wu Huadong , Wang Rongying , Zhang Min
Published: February 2024

Background:

This study aims to investigate the knowledge of rural general practitioners (GPs) in esophageal cancer (EC) prevention and treatment in China and analyze relevant influencing factors, so as to improve the ability of rural GPs in EC prevention and treatment.

Methods:

This cross-sectional study was conducted from November 5, 2021, to November 20, 2021. A self-designed questionnaire was used to conduct an online survey. Multivariable logistic regression models were used to identify the influencing factors of knowledge proficiency of GPs in rural China for EC prevention and treatment.

Results:

This study included 348 participants from 12 rural areas in Hebei Province. The mean accuracy rate on all question items was 42.3% ± 10.67%. Sex (OR = 2.870, 95% CI: 1.519–5.423), educational level (OR = 3.256, 95% CI: 1.135–9.339), and comprehension of clinical practice guidelines for EC (OR = 4.305, 95% CI: 2.023–9.161) were significant predictors for GPs’ knowledge proficiency of EC prevention and treatment (P< 0.05).

Conclusions:

The study indicated that knowledge proficiency of rural GPs of EC prevention and control still awaits to be improved. Sex, educational level, and comprehension of clinical practice guidelines for EC were significant predictors for their proficiency.
Ethnic minority MPs as reputational shields? How Western European political parties respond to public opinion shifts on immigration policy
Authors: van de Wardt Marc , Sobolewska Maria , English Patrick
Published: February 2024

In recent decades, representation of ethnic minorities increased significantly across Europe, while concurrently many political parties moved to the right on multiculturalism and immigration, a seeming paradox. We explain it by arguing that often it is the same parties that move to the right and simultaneously increase representation. They use this dual strategy in an attempt to positionally converge to the median voter, where the increased minority representation acts as a reputational shield to prevent allegations of intolerance. Looking at parliaments of eight European countries between 1990 and 2015, we find that parties that shifted to the right in response to a public mood swing to the right are indeed significantly more likely to bring more ethnic minority politicians into parliament. This has important implications for the literature on descriptive representation and party platform change.
An enhanced wideband tracking method for characteristic modes
Authors: Huang Chao , Guo Chenjiang , Ma Xia , Yuan Yi , Ding Jun
Published: February 2024

An enhanced wideband tracking method for characteristic modes (CMs) is investigated in this paper. The method consists of three stages, and its core tracking stage (CTS) is based on a classical eigenvector correlation-based algorithm. To decrease the tracking time and eliminate the crossing avoidance (CRA), we append a commonly used eigenvalue filter (EF) as the preprocessing stage and a novel postprocessing stage to the CTS. The proposed postprocessing stage can identify all CRA mode pairs by analyzing their trajectory and correlation characteristics. Subsequently, it can predict corresponding CRA frequencies and correct problematic qualities rapidly. Considering potential variations in eigenvector numbers at consecutive frequency samples caused by the EF, a new execution condition for the adaptive frequency adjustment in the CTS is introduced. Finally, CMs of a conductor plate and a fractal structure are investigated to demonstrate the performance of the proposed method, and the obtained results are discussed.
Interdependencies Between Wildfire‐Induced Alterations in Soil Properties, Near‐Surface Processes, and Geohazards
Authors: Vahedifard Farshid , Abdollahi Masood , Leshchinsky Ben A. , Stark Timothy D. , Sadegh Mojtaba , AghaKouchak Amir
Published: February 2024

The frequency, severity, and spatial extent of destructive wildfires have increased in several regions globally over the past decades. While direct impacts from wildfires are devastating, the hazardous legacy of wildfires affects nearby communities long after the flames have been extinguished. Post‐wildfire soil conditions control the persistence, severity, and timing of cascading geohazards in burned landscapes. The interplay and feedback between geohazards and wildfire‐induced changes to soil properties, land cover conditions, and near‐surface and surface processes are still poorly understood. Here, we synthesize wildfire‐induced processes that can affect the critical attributes of burned soils and their conditioning of subsequent geohazards. More specifically, we discuss the state of knowledge pertaining to changes in mineralogical, hydraulic, mechanical, and thermal properties of soil due to wildfire with a focus on advances in the past decade. We identify how these changes in soil properties alter evapotranspiration, interception, sediment transport, infiltration, and runoff. We then link these alterations to the evolution of different geohazards, including dry raveling, erosion, rockfalls, landslides, debris flows, and land subsidence. Finally, we identify research gaps and future directions to advance knowledge on how wildfires control the evolution of various earth surface processes and geohazards over time.
KNMI'23 Climate Scenarios for the Netherlands: Storyline Scenarios of Regional Climate Change
Authors: van der Wiel Karin , Beersma Jules , van den Brink Henk , Krikken Folmer , Selten Frank , Severijns Camiel , Sterl Andreas , van Meijgaard Erik , Reerink Thomas , van Dorland Rob
Published: February 2024

This paper presents the methodology for the construction of the KNMI'23 national climate scenarios for the Netherlands. We have developed six scenarios, that cover a substantial part of the uncertainty in CMIP6 projections of future climate change in the region. Different sources of uncertainty are disentangled as much as possible, partly by means of a storyline approach. Uncertainty in future emissions is covered by making scenarios conditional on different SSP scenarios (SSP1‐2.6, SSP2‐4.5, and SSP5‐8.5). For each SSP scenario and time horizon (2050, 2100, 2150), we determine a global warming level based on the median of the constrained estimates of climate sensitivity from IPCC AR6. The remaining climate model uncertainty of the regional climate response at these warming levels is covered by two storylines, which are designed with a focus on the annual and seasonal mean precipitation response (a dry‐trending and wet‐trending variant for each SSP). This choice was motivated by the importance of future water management to society. For users with specific interests we provide means how to account for the impact of the uncertainty in climate sensitivity. Since CMIP6 GCM data do not provide the required spatial detail for impact modeling, we reconstruct the CMIP6 responses by resampling internal variability in a GCM‐RCM initial‐condition ensemble. The resulting climate scenarios form a detailed storyline of plausible future climates in the Netherlands. The data can be used for impact calculations and assessments by stakeholders, and will be used to inform policy making in different sectors of Dutch society.
The Chemical Effect of Increased Water Vapor From the Hunga Tonga‐Hunga Ha'apai Eruption on the Antarctic Ozone Hole
Authors: Wohltmann Ingo , Santee Michelle L. , Manney Gloria L. , Millán Luis F.
Published: February 2024

The eruption of the Hunga Tonga‐Hunga Ha'apai volcano on 15 January 2022 was one of the most explosive eruptions of the last decades. The amount of water vapor injected into the stratosphere was unprecedented in the observational record, increasing the stratospheric water vapor burden by about 10%. Using model runs from the ATLAS chemistry and transport model and Microwave Limb Sounder (MLS) satellite observations, we show that while 20%–40% more water vapor than usual was entrained into the Antarctic polar vortex in 2023 as it formed, the direct chemical effect of the increased water vapor on Antarctic ozone depletion in June through October was minor (less than 4 DU). This is because low temperatures in the vortex, as occur every year in the Antarctic, limit water vapor to the saturation pressure and thus reset any anomalies through the process of dehydration before they can affect ozone loss.
Plasma Observations in the Distant Magnetotail During Intervals of Northward IMF
Authors: Mooney M. K. , Milan S. E. , Bower G. E.
Published: February 2024

We examine a 6‐day traversal of the magnetotail by the ARTEMIS satellites during an interval of prolonged northward IMF. The electrostatic analyzer (ESA) onboard the ARTEMIS spacecraft measures high ion and electron fluxes at approximately 60 RE downtail in regions of the magnetotail which would normally be the magnetotail lobe, containing open flux evacuated of plasma. We interpret these observations as trapped plasma on closed magnetic flux indicating that the magnetotail is closed or partially closed but extends at least as far as ∼60 RE downtail. We find that the occurrence of plasma in the magnetotail and the closure of the magnetosphere results in distinct changes to the magnetotail structure including a reduction in the magnetic field strength and pressure as well as a narrowing of the tail by approximately 20 RE.
Limited Evidence for a Microbial Signal in Ground‐Level Smoke Plumes
Authors: Gering Sarah M. , Sullivan Amy P. , Kreidenweis Sonia M. , McMurray Jill A. , Fierer Noah
Published: February 2024

Recent studies have suggested that microbial aerosolization in wildfire smoke is an understudied source of microbes to the atmosphere. Wildfire smoke can travel thousands of kilometers from its source with the potential to facilitate the transport of microbes, including microbes that can have far‐reaching impacts on human or ecosystem health. However, the relevance of longer‐range detection of microbes in smoke plumes remains undetermined, as previous studies have mainly focused on analyses of bioaerosols collected adjacent to or directly above wildfires. Therefore, we investigated whether wildfire smoke estimated to originate >30 km from different wildfire sources would contain detectable levels of bacterial and fungal DNA at ground level, hypothesizing that smoke‐impacted air would harbor greater amounts and a distinct composition of microbes as compared to ambient air. We used cultivation‐independent approaches to analyze 150 filters collected over time from three sampling locations in the western United States, of which 34 filters were determined to capture wildfire smoke events. Contrary to our hypothesis, smoke‐impacted samples harbored lower amounts of microbial DNA. Likewise, there was a limited signal in the composition of the microbial assemblages detected in smoke‐affected samples as compared to ambient air, but we did find that changes in humidity were associated with temporal variation in the composition of the bacterial and fungal bioaerosols. With our study design, we were unable to detect a robust and distinct microbial signal in ground‐level smoke originating from distant wildfires.
Anzali Wetland Crisis: Unraveling the Decline of Iran's Ecological Gem
Authors: Mahdian M. , Noori R. , Salamattalab M. M. , Heggy E. , Bateni S. M. , Nohegar A. , Hosseinzadeh M. , Siadatmousavi S. M. , Fadaei M. R. , Abolfathi S.
Published: February 2024

The wetland loss rate in Iran is faster than the global average. Comprehending the shrinkage rate in Iranian wetlands and identifying the underlying drivers of these changes is essential for safeguarding their ecosystems' health and services. This study proposes a novel gray‐box modeling framework to quantify the effects of climate change and anthropogenic activities on the wetlands, by combining process‐based and machine learning models. The developed model is utilized to project the Anzali coastal wetland shrinkage by simulating the complex interaction between the meteorological, hydrological, anthropogenic and sea water level characteristics, and the changes in wetland water surface area. Our framework aggregates Soil and Water Assessment Tool model, the 12 General Circulation Models of the Coupled Model Intercomparison Project Phase 6, Landsat imagery, and the Long Short‐Term Memory model to project the shrinkage of the wetland till 2100. A comprehensive range of climate and Land Use/Cover change scenarios are analyzed. The results show that wetland will seasonally desiccate in 2058, mainly due to increasing air temperature, reduction in precipitation and inflow, excessive sediment loading to the wetland, and decline in the Caspian Sea level. For optimistic scenarios, where no changes in the Caspian Sea level is considered, the wetland will gradually diminish and become a seasonal waterbody by 2100. The outcomes of this study highlight that the Anzali wetland desiccation has profound implications for the regional‐scale ecological balance, ecosystem health and function, public health, and local economy. Robust environmental interventions and sustainable development strategies are urgently needed to mitigate the detrimental impacts of climate and anthropogenic drivers on the wetland.
Exploiting epigenetic targets to overcome taxane resistance in prostate cancer
Authors: Cevatemre Buse , Bulut Ipek , Dedeoglu Beyza , Isiklar Arda , Syed Hamzah , Bayram Ozlem Yedier , Bagci-Onder Tugba , Acilan Ceyda
Published: February 2024

The development of taxane resistance remains a major challenge for castration resistant prostate cancer (CR-PCa), despite the effectiveness of taxanes in prolonging patient survival. To uncover novel targets, we performed an epigenetic drug screen on taxane (docetaxel and cabazitaxel) resistant CR-PCa cells. We identified BRPF reader proteins, along with several epigenetic groups (CBP/p300, Menin-MLL, PRMT5 and SIRT1) that act as targets effectively reversing the resistance mediated by ABCB1. Targeting BRPFs specifically resulted in the resensitization of resistant cells, while no such effect was observed on the sensitive compartment. These cells were successfully arrested at the G2/M phase of cell cycle and underwent apoptosis upon BRPF inhibition, confirming the restoration of taxane susceptibility. Pharmacological inhibition of BRPFs reduced ABCB1 activity, indicating that BRPFs may be involved in an efflux-related mechanism. Indeed, ChIP-qPCR analysis confirmed binding of BRPF1 to the ABCB1 promoter suggesting direct regulation of the ABCB1 gene at the transcriptional level. RNA-seq analysis revealed that BRPF1 knockdown affects the genes enriched in mTORC1 and UPR signaling pathways, revealing potential mechanisms underlying its functional impact, which is further supported by the enhancement of taxane response through the combined inhibition of ABCB1 and mTOR pathways, providing evidence for the involvement of multiple BRPF1-regulated pathways. Beyond clinical attributes (Gleason score, tumor stage, therapy outcome, recurrence), metastatic PCa databases further supported the significance of BRPF1 in taxane resistance, as evidenced by its upregulation in taxane-exposed PCa patients.
HNF4α ubiquitination mediated by Peli1 impairs FAO and accelerates pressure overload-induced myocardial hypertrophy
Authors: Hou Yuxing , Shi Pengxi , Du Haiyang , Zhu Chenghao , Tang Chao , Que Linli , Zhu Guoqing , Liu Li , Chen Qi , Li Chuanfu , Shao Guoqiang , Li Yuehua , Li Jiantao
Published: February 2024

Impaired fatty acid oxidation (FAO) is a prominent feature of metabolic remodeling observed in pathological myocardial hypertrophy. Hepatocyte nuclear factor 4alpha (HNF4α) is closely associated with FAO in both cellular processes and disease conditions. Pellino 1 (Peli1), an E3 ligase containing a RING-like domain, plays a crucial role in catalyzing polyubiquitination of various substrates. In this study, we aimed to investigate the involvement of HNF4α and its ubiquitination, facilitated by Peli1, in FAO during pressure overload-induced cardiac hypertrophy. Peli1 systemic knockout mice (Peli1KO) display improved myocardial hypertrophy and cardiac function following transverse aortic constriction (TAC). RNA-seq analysis revealed that changes in gene expression related to lipid metabolism caused by TAC were reversed in Peli1KO mice. Importantly, both HNF4α and its downstream genes involved in FAO showed a significant increase in Peli1KO mice. We further used the antagonist BI6015 to inhibit HNF4α and delivered rAAV9-HNF4α to elevate myocardial HNF4α level, and confirmed that HNF4α inhibits the development of cardiac hypertrophy after TAC and is essential for the enhancement of FAO mediated by Peli1 knockout. In vitro experiments using BODIPY incorporation and FAO stress assay demonstrated that HNF4α enhances FAO in cardiomyocytes stimulated with angiotension II (Ang II), while Peli1 suppresses the effect of HNF4α. Mechanistically, immunoprecipitation and mass spectrometry analyses confirmed that Peli1 binds to HNF4α via its RING-like domain and promotes HNF4α ubiquitination at residues K307 and K309. These findings shed light on the underlying mechanisms contributing to impaired FAO and offer valuable insights into a promising therapeutic strategy for addressing pathological cardiac hypertrophy.
The molecular interaction pattern of lenvatinib enables inhibition of wild-type or kinase-mutated FGFR2-driven cholangiocarcinoma
Authors: Spahn Stephan , Kleinhenz Fabian , Shevchenko Ekaterina , Stahl Aaron , Rasen Yvonne , Geisler Christine , Ruhm Kristina , Klaumuenzer Marion , Kronenberger Thales , Laufer Stefan A. , Sundberg-Malek Holly , Bui Khac Cuong , Horger Marius , Biskup Saskia , Schulze-Osthoff Klaus , Templin Markus , Malek Nisar P. , Poso Antti , Bitzer Michael
Published: February 2024

Fibroblast growth factor receptor (FGFR)−2 can be inhibited by FGFR-selective or non-selective tyrosine kinase inhibitors (TKIs). Selective TKIs are approved for cholangiocarcinoma (CCA) with FGFR2 fusions; however, their application is limited by a characteristic pattern of adverse events or evocation of kinase domain mutations. A comprehensive characterization of a patient cohort treated with the non-selective TKI lenvatinib reveals promising efficacy in FGFR2-driven CCA. In a bed-to-bench approach, we investigate FGFR2 fusion proteins bearing critical tumor-relevant point mutations. These mutations confer growth advantage of tumor cells and increased resistance to selective TKIs but remain intriguingly sensitive to lenvatinib. In line with clinical observations, in-silico analyses reveal a more favorable interaction pattern of lenvatinib with FGFR2, including an increased flexibility and ligand efficacy, compared to FGFR-selective TKIs. Finally, the treatment of a patient with progressive disease and a newly developed kinase mutation during therapy with a selective inhibitor results in a striking response to lenvatinib. Our in vitro, in silico, and clinical data suggest that lenvatinib is a promising treatment option for FGFR2-driven CCA, especially when insurmountable adverse reactions of selective TKIs or acquired kinase mutations occur.