bluuebunny/crossref_metadata_2025 huggingface dataset:
EL QUEBRANTO DEL ESTADO DE DERECHO EN BOLIVIA, EN LA ÚLTIMA DÉCADA
Authors: Mendoza Orosco Gustavo
Published: January 2025

El objetivo del presente es generar un análisis reflexivo sobre el quebranto sistemático del Estado de Derecho en Bolivia, identificando acontecimientos suscitados en la última década, a fin de comprender la problemática.
El Estado de Derecho, plasmado como un principio con la Rev. Francesa de 1789, surge ante la necesidad de limitar el ejercicio absoluto y arbitrario del poder del gobernante, el Estado de Derecho desde un enfoque clásico, se entiende como un Estado donde gobernantes y gobernados se someten en igualdad de condiciones a Derecho, la doctrina establece características que permiten diagnosticar una mayor o menor vigencia de éste, como ser: La supremacía del Constitución, división de funciones, responsabilidad de la administración y el respeto a los DD.HH.
El gobernante en Bolivia es proclive a no acatar la norma, si está no es favorable para sus intereses, ello aconteció durante la administración de Evo Morales, cuando la Constitución limitó la posibilidad de reelección consecutiva por solo una vez, acudió a interpretaciones del Tribunal Constitucional Plurinacional, para desconocer este límite en más de una ocasión, la primera valiéndose de la Declaración Constitucional No. 0003/2013, desconociendo la disposición transitoria primera II, de la CPE, para habilitar su segunda reelección; y la segunda mediante la SCP 84/2017 que pone en evidencia el sometimiento del este Tribunal, al declarar como un derecho ilimitado la reelección indefinida, para habilitar su tercera reelección, desconociendo no solo los límites de la Constitución, sino también la voluntad del pueblo soberano expresada mediante referéndum de 2016, en el cual se reafirma el límite a la reelección por solo una oportunidad de forma inmediata.
Por tanto, cuando el Gobernante no se somete a la Constitución, los órganos de poder quedan sometidos a un órgano, y/o no se acatan los límites al ejercicio del poder, no se puede pretender la vigencia efectiva de un Estado de Derecho.
Optimisation of the strategy of state support for small and medium-sized enterprises at the regional level through investment and innovation measures
Authors: Ustymenko Mariya
Published: January 2025

The purpose of this study was to develop an optimised strategy for state support of small and medium-sized enterprises at the regional level of Ukraine through the implementation of innovation and investment measures aimed at increasing their competitiveness and sustainability in the face of current economic challenges. The study was based on the analysis of key challenges faced by small and medium-sized enterprises, such as limited access to financial resources, low level of innovation, difficulties in integrating into international markets, and insufficient cooperation with research institutions and government agencies. The analysis covered three regions of Ukraine: Kyiv, Lviv, and Dnipro regions. The key findings of this study included the development of recommendations to improve the effectiveness of state support for small and medium-sized enterprises, which should account for regional characteristics and needs. It was proposed to introduce innovation clusters to strengthen cooperation between businesses, research institutions, and government agencies to create innovative products and services. The study also emphasised the significance of business digitalisation, which would increase the efficiency of small and medium-sized enterprises, reduce costs, and facilitate access to new markets. Particular attention was paid to the need to attract private investment through public-private partnership mechanisms to finance innovative projects, which would help modernise enterprises and increase their competitiveness both nationally and internationally. Specifically, the introduction of innovation clusters will not only stimulate the development of advanced technologies but will also facilitate the exchange of knowledge between enterprises and research institutions, which will increase the overall level of innovation in the regions. For this, it is necessary to create a favourable environment for the development of such clusters, including financial support, tax incentives, and training programmes for entrepreneurs. Another significant aspect is the development of digital technologies that can transform business processes in small and medium-sized enterprises
Central Asian pension systems: A comparative analysis of achievements, risks and development mechanisms
Authors: Aliev Bakhtiyar , Kamchybekov Tolobek , Dzhailov Dzhumabek , Fu Shanning
Published: January 2025

The purpose of this study was to analyse the pension systems of Central Asian countries to evaluate the effectiveness of pension reforms and identify key challenges impacting their financial sustainability. The study focused on the impact of labour migration, informal employment and demographic changes on the pension systems of these countries. A comparative analysis was conducted to assess the pension systems based on key indicators such as pension fund contributions, demographic trends, and the structure of pension models – pay-as-you-go, funded, or hybrid. The results of the study showed significant differences between the pension systems of Central Asian countries. Kazakhstan had introduced a funded pension system, but was facing problems due to low investment returns and public distrust. Uzbekistan, despite efforts to integrate migrant workers into the pension system, still struggles with insufficient contributions from the informal sector. Turkmenistan maintains a public pension system, but a lack of transparency limits the ability to assess its long-term viability. Kyrgyzstan has introduced a hybrid pension system, but labour migration and the informal economy undermine its effectiveness. Tajikistan continues to rely on the traditional pay-as-you-go model, but economic instability and migration pose serious financial challenges. Thus, pension systems in Central Asia share common challenges, especially in managing labour migration and covering informal workers. Ongoing reforms are needed to improve financial management, diversify investments, and expand coverage to ensure the sustainability of pension funds
Total hip arthroplasty after pelvic osteotomy: a meta-analysis
Authors: HUAN S.-W. , WU W.-R. , PENG S.-J. , ZHUANG T.-F. , LIU N
Published: January 2025

Several studies suggested that total hip arthroplasty (THA) was more technical demanding following previous pelvic osteotomy (PO), resulting in poor outcomes compared with primary THA. However, the other studies regarding this topic had reported contradictory results. Therefore, we conducted this meta-analysis to compare the clinical results and other parameters between total hip arthroplasty following pelvic osteotomy and primary total hip arthroplasty. We systematically searched PubMed, the Cochrane Library, EMBASE, Web of Science, Scopus, EBSCO and Web of science from inception to September 2020. This study compared the outcomes between THA following previous PO and primary THA with respect to operative time, blood loss, Harris hip score (HHS), revision rates, complication rates, cup position, cup size, cup coverage and hip joint center. 14 studies with 3913 participants were included. The THA after PO group had longer operative time (MD, 13.8 mins; 95% CI, 4.73 to 22.87 mins; P=0.003), greater blood loss (MD, 82.21 ml; 95% CI, 27.94 to 136.48 ml; P=0.003), worse HHS (MD, -2.79 points; 95% CI, -4.08 to -1.50 points; P<0.00001), smaller acetabular anteversion angle (MD, -3.98°; 95% CI, -6.72 to -1.24°; P=0.004), larger cup size (MD, 1.52 mm; 95% CI, 0.75 to 2.28 mm; P=0.0001), more lateral (MD, 2.83 mm; 95% CI, 1.22 to 4.43 mm; P=0.0005) and superior (MD, 2.26 mm; 95% CI, 1.11 to 3.40 mm; P=0.0001) hip joint center. No statistically significant differences were demonstrated between the THA after PO group and primary THA group in revision rates, complication rates, acetabular abduction angle, cup coverage. THA after pelvic osteotomy was associated with inferior intraoperative outcomes, lower functional scores and worse inferior positioning of acetabular component compared with primary THA. Due to the alerted anatomical structure after PO, the findings of current study implicated that preoperative assessment such as computed tomography scan should be conducted in order to achieve satisfactory results.
Are the outcomes of bone transport in the treatment of bone defects in the upper- middle and lower-middle tibia similar?
Authors: XUMING W , CHANGBAO W , YANPING D , QUDONG Y , SHENG S
Published: January 2025

The aim of the study was to compare the outcomes of bone transport in treating upper- middle vs. lower- middle tibial bone defects. Sixty-two patients with tibial infected large segmental defects treated by bone transport were analyzed retrospectively and divided into distal group (lower- middle tibial bone defects and proximal transport, n=38) and proximal group (upper- middle tibial bone defects and distal transport, n=24). The demographic data were not significant different (P > 0.05). External fixation index (ETI), bone defect union time (BDUT), regenerate consolidation time (RCT), bone healing and functional outcomes evaluated by Association for the Study and Application of the Methods of Ilizarov score, postoperative complications evaluated by Paley classification, and the American Orthopaedic Foot and Ankle Society (AOFAS) score were recorded and compared at a minimum follow-up of 20 months. There were no significant differences in flap repair, follow-up time, ETI, RCT, bone healing, functional outcomes and complications between the two groups (P > 0.05). However, in the distal group, the BDUT was significantly longer, and the AOFAS score was significantly lower than those in the proximal group (17.5±2.5 vs 15.9±3.1 months, 70.0±5.5 vs 72.8±4.8, respectively) (P < 0.05). The overall outcomes of bone transport in treating upper- middle vs. lower- middle tibial bone defects are similar. However, the upper- middle tibia bone defects heal faster than the lower- middle tibial bone defects, and distal transport has a greater adverse effect on the ankle and foot joints than proximal transport. Therefore, traditional distal tibial transport near the ankle joint should be taken with caution.
Piezoelectric patch-based metamaterial on thin plates with arrays of separately shunted patches-validation and optimization
Authors: Acar Mustafa Kemal , Motlagh Peyman Lahe
Published: January 2025

Lightweight structures tend to be susceptible to vibration, which can lead to fatigue and failure. Piezoelectric shunt damping is an efficient technology that converts mechanical energy into electrical energy and dissipates it through shunt circuits without requiring external power. This study models several piezoelectric patches coupled to different shunt circuits on a thin plate, utilizing Rayleigh-Ritz modal analysis to examine patch parameters including size, position, and distribution. Optimization demonstrates that effective patch-circuit topologies correspond with structural mode shapes, resulting in maximum vibration reduction. The findings introduce a fresh technique to enhance vibration control which improves structural reliability and performance.
Leveraging AI for Predicting Marketing and Customer Insights-An Overview
Authors: Mohan Cherian
Published: January 2025

Artificial Intelligence (AI) is transforming marketing and customer engagement by facilitating businesses to predict trends, enhance decision-making, and improve customer experiences through technologies like machine learning, predictive analytics, and natural language processing. Important applications include customer segmentation, sentiment analysis, and predictive analytics for forecasting purchasing behavior. Chatbots and virtual assistants have automated customer service and boosted sales. However, AI adoption faces challenges such as data privacy concerns, regulatory issues, algorithmic biases, and resource constraints, particularly for small businesses. Despite these hurdles, advancements in deep learning and generative AI are unlocking new opportunities for personalized customer engagement through augmented reality (AR), virtual reality (VR), and customized content. The paper also explores future opportunities, such as integrating AI with blockchain for secure data sharing and leveraging the Internet of Things (IoT) for real-time insights into consumer behavior. The findings of the study indicate that AI, when responsibly applied, not only enhances marketing efficiency and personalization but also facilitates innovative strategies that redefine customer engagement and market responsiveness. A comprehensive analysis is presented on the topics mentioned above.
Some new integral inequalities for exponential type P-functions
Authors:   Bayburt University, Turkey, Mahir Kadakal , İmdat İşcan ,   Giresun University, Turkey, Huriye Kadakal ,   Bayburt University, Turkey
Published: January 2025

In this paper, by using an identity we obtain some new Hermite-Hadamard type inequalities for functions whose first derivative in absolute value is exponential type P-function by using Hölder and power-mean integral inequalities. Then, the aouthors compare the results obtained with both Hölder, Hölder-İşcan integral inequalities and prove that the Hölder-İşcan integral inequality gives a better approximation than the Hölder integral inequality. Also, some applications to special means of real numbers are also given.
Existence of solutions for a class of superlinear anisotropic Robin problems with variable exponent
Authors:   University Mohamed I, Faculty of sciences, Department of mathematics, Morocco, Abdelrachid El Amrouss , Fouad Kissi ,   University Mohamed I, Faculty of sciences, Department of mathematics, Morocco, Ali El Mahraoui ,   University Mohamed I, Faculty of sciences, Department of mathematics, Morocco
Published: January 2025

In this work we study the following nonlinear anisotropic elliptic equations
$$ (P)\left\{ \begin{array}{lr}
-\sum_{i=1}^{N}\partial_{x_{i}}(|\partial_{x_{i}}u|^{p_{i}(x)-2}\partial_{x_{i}}u)+ |u|^{p_M(x)-2}u = f(x,u) & \quad in \quad \Omega\\
\sum_{i=1}^{N}|\partial_{x_{i}}u|^{p_{i}(x)-2}\partial_{x_{i}}u.\nu_i + \beta(x) |u|^{p_m(x)-2}u = 0 & \quad on \quad \partial\Omega.
\end{array} \right.$$
We set up that the problem $(P)$ admits a sequence of weak solutions and multiplicity result under suitable conditions.
Some harmonic and biharmonic problems on the tangent bundle with a Berger-type deformed Sasaki metric
Authors:   Department of Mathematics, University of Mascara, Algeria, Abdallah Medjadj , Hichem El Hendi ,   Department of Mathematics, Laboratory of Pure and Applied Mathematics, University of Mostaganem, Algeria, Lakehal Belarbi ,   Department of Mathematics, University of Mostaganem, Algeria
Published: January 2025

Let $\psi:(M_{2k},\phi, g)\longrightarrow (N_{2k'},\phi', h)$ be a smooth map between almost anti-paraHermitian manifolds. The map $\psi$ induces the tangent map $\Psi:(TM,g^{BS})\longrightarrow (TN,h^{BS})$. In this paper, we deal with the harmonicity of a tangent map $\Psi$ and the biharmonicity of the identity map in the case where the tangent bundles $TM,TN$ are endowed with the Berger type deformed Sasaki metric $g^{BS}, h^{BS}$.
Bifurcation analysis of a class of polyharmonic semilinear equations with perturbed potential
Authors:   University of Tunis El Manar, Higher Institut of Medicals Technologies of Tunis, Tunisia, Imed Abid , Sami Baraket ,   Department of Mathematics and Statistics, College of Science, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Saudi Arabia
Published: January 2025

Many problems of mechanics were described by polyharmonic equations [9]. Moreover, the areas of physics and geometry where such operators occur, include the study of the Kirchhoff plate equation in the theory of elasticity, and the study of the Paneitz-Branson operator in conformal geometry, see [9]. Inverse spectral problems for a potential perturbation of the polyharmonic operator were studied in [12].
The polyharmonic operator (−Δ)m is the prototype of an elliptic operator of order 2m. A general theory for boundary value problems for linear elliptic operators of order 2m was developed by Agmon-Douglis-Nirenberg in [2, 3] and Berchio-Gazzola in [5]. Although the material is quite technical, it turns out that the Lp-theory can be developed to a large extent analogously to second order equations. As long as existence, regularity and stability results are concerned, the theory of semi-linear higher order problems is already quite well developed. This is no longer true as soon as qualitative properties of the solution related to the bifurcation problems are investigated.
Local dynamics and bifurcation for a two-dimensional cubic Lotka-Volterra system (Part II)
Authors:   University of Craiova, Romania, Mihaela Sterpu , Raluca Efrem ,   University of Craiova, Romania
Published: January 2025

The local bifurcation and dynamics for a two-dimensional cubic Kolmogorov system, depending on two small parameters, in certain hypotheses on the coefficients, are investigated. The paper continues the study performed in [4], by treating two non-generic cases, corresponding to the hypotheses that one of the significant coefficients vanishes. In the first non-generic case, the local dynamics is found to be similar to the one obtained in the generic case treated in [4]. In the second non-generic case new possibilities of behavior are found.
Productos comerciales alternativos para la madera aserrada de Pino radiata que no califica como estructural
Authors:   Instituto Forestal (Chile), Arriagada Macarena , Troncoso Leonardo , Hernández Gonzalo
Published: January 2025

En Julio 2024 entró en vigencia para la micro y pequeña empresa el Decreto de Rotulado de la madera aserrada estructural para la construcción, el cual establece los requisitos mínimos de rotulación que deben cumplir este tipo de madera. Considerando que no toda la madera aserrada que producen los aserraderos califica para su uso en la construcción, tales como tabiques, cerchas, envigados de piso, entre otros, surge la necesidad por identificar usos alternativos industriales para este tipo de madera.
Anuario forestal 2024
Authors:   Instituto Forestal (Chile), Poblete Pamela , Kahler Carlos , Bañados Juan Carlos , Gysling Janina , Pardo Evaristo , Soto Daniel , Baeza Daniela , Catelicán Luis , Hernández Joselyn , Troncoso Hans
Published: January 2025

La actual edición del Anuario Forestal 2024 conserva su estructura tradicional de ocho capítulos. Estos capítulos incluyen información de indicadores macroeconómicos, estado del recurso forestal, consumo de trozas y producción industrial, comercio exterior, precios de productos forestales, transporte, disponibilidad futura de madera en pie y ocupación forestal. Este año, además de la actualización de los datos, el capítulo 3 “Consumo de trozas y producción de la Industria forestal”, se divide en dos subcapítulos, uno dedicado a la “Industria Forestal Primaria” y otro a la “Industria secundaria de la madera”. También por primera vez se incluyen estadísticas de la industria de puertas, ventanas y molduras de madera, un esfuerzo realizado por INFOR con el apoyo de CORFO. Asimismo, es importante destacar la incorporación de infografías para facilitar la interpretación de la información más relevante de cada capítulo. Una novedad de la presente edición es la inclusión de datos del PIB a nivel de componentes, lo cual no estaba disponible en versiones anteriores. Esto responde a la necesidad de brindar una visión más completa y detallada del impacto económico del sector forestal del país.
Strategic workload management in digital business
Authors: Kristinawati Didin , Ghalib Ghalib Kamal
Published: January 2025

This study aims to analyze workload distribution at ISPCX, a leading internet service provider in Bandung, to identify imbalances and propose strategies for optimizing resource allocation and operational efficiency. The study employs a single-case study approach, integrating both quantitative and qualitative methods. Data were collected through document analysis, employee surveys, semi-structured interviews, and direct observations. The Full-Time Equivalent (FTE) method was utilized to calculate workload ratios, providing a quantitative measure of workforce utilization. The analysis revealed significant workload disparities across roles and divisions. Overburdened roles, such as the Manager in the General Affairs Division (workload ratio 3.24), risk employee burnout. Conversely, underutilized roles in the Technical Division, like the Manager (0.30), indicate inefficiencies in task alignment. Balanced roles were observed in specific administrative positions, highlighting potential best practices. The findings underscore the importance of strategic task redistribution and leveraging digital tools to improve efficiency and reduce employee strain. This study provides actionable insights for digital businesses, emphasizing the role of evidence-based workload management in driving economic growth and sustainable development.
Discovering Greenwashing Behavior Patterns: A Systematic Literature
Review Approach
Authors: Shi-Ming Huang Shi-Ming Huang , Shi-Ming Huang Shang-Heng Chung , Shang-Heng Chung Ching-Fang Huang , Ching-Fang Huang Kai-Qi Zhan
Published: January 2025

As technology advances and environmental awareness grows, the ESG concept has deeply influenced society and businesses. However, some companies, while promoting sustainability commitments, evade their actual responsibilities, leading to the rise of greenwashing. This behavior undermines genuine efforts and fosters public distrust, potentially causing as much harm as environmental pollution. This study proposes a machine learning approach, using a Systematic Literature Review to analyze recent research on greenwashing. The analysis highlights key research trends across various fields and identifies significant growth in 2022 and 2023. It ultimately uncovers essential features of corporate greenwashing and commonly used tactics, aiming to provide a framework for intelligent detection of greenwashing.

 
How NGOs in India Can Navigate ESG Audit ＆ Assurance Challenges
Authors: Gladstone Samuel Gladstone Samuel
Published: January 2025

Non-GovernmentalOrganizations (NGOs) in India play an essential role in promoting sustainable development and social welfare. To enhance their impact, navigating the challenges of Environmental, Social, and Governance (ESG) audits and assurance has become increasingly important. This report examines the evolving ESG landscape, focusing on how NGOs can align their operations, reporting, and governance practices with recognized local frameworks. The key challenges highlighted include financial constraints, complex regulations, a lack of technical expertise, and inconsistent reporting standards. The study highlights strategies for overcoming these barriers, including capacity-building initiatives, collaborative partnerships, and leveraging technology-driven solutions for transparent reporting and data management. Case studies from pioneering Indian NGOs provide actionable insights into best practices in ESG audits. By addressing these ESG challenges effectively, NGOs can enhance their credibility, unlock new funding opportunities, and create long-term social and environmental value. This report serves as a guide for NGO leaders, auditors, and policy-makers committed to fostering a sustainable and accountable nonprofit ecosystem in India.

 
Annie Denton Cridge’s Healthy Utopia: The Associative Underpinnings of “Man’s Rights; or, How Would You Like It?”
Authors: Garcia Ashley
Published: January 2025

In 1870, Woodhull & Claflin’s Weekly published the first number of Annie Denton Cridge’s utopian novel entitled “Man’s Rights; or, How Would You Like It?” Scholars have traditionally characterized Cridge’s story as a work of early feminist writing. However, they have overlooked Cridge’s connection to the American Associationist movement, a utopian-socialist movement inspired by the writings of French philosopher, Charles Fourier. Cridge and her husband were inspired by Fourier and the work of American Associationists as early as the 1850s. While many scholars argue that the Associative movement crumbled in the 1850s, Cridge’s story demonstrates that the movement’s ideas and converts persisted even after the Civil War. Furthermore, Cridge’s story appeared decades before Edward Bellamy’s Looking Backward (1888) and Charlotte Perkins Gilman’s Herland (1915) and featured aspects of communal life that became mainstays in later utopian literature such as cooperative housekeeping. This article’s characterization of Cridge’s story as an Associative work of fiction encourages us to consider the myriad ways in which Americans took part in utopian-socialist movements, and urges further investigation into the influence that the Associative movement had on the utopian literary tradition in America.
Wish We Were There: Hope, Desire, and Utopian Community in Contemporary Solarpunk
Authors: Weik Von Mossner Alexa
Published: January 2025

Solarpunk’s commitment to the creation of hopeful and desirable futures may have transformative potential at a time when people are growing tired of the never-ending list of bad news. Its dynamic of realist audacity and radical hope makes it a fascinating genre to explore, but the importance of a third emotional state—utopian desire—is rarely mentioned explicitly. In Ruth Levitas’s influential definition, utopia is “an expression of desire for a different way of living and being.” The article argues that solarpunk is suffused and propelled by that desire not only in its manifold speculative storyworlds but also in its insistence on collective transformative action.
NON-ALCOHOLIC FATTY LIVER DISEASE AND ITS RELATIONSHIP WITH METABOLIC SYNDROME: MODERN APPROACHES TO TREATMENT AND PREVENTION
Authors: Bazargaliyev Sh.Y. , Madenbayeva A.M. , Kudabayeva I.K. , Rysmaganbetov S.S.
Published: January 2025

Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) are increasingly recognized as major public health concerns due to their high global prevalence and association with severe long-term health outcomes, including cardiovascular diseases, type 2 diabetes, and liver-related complications. This article explores the relationship between NAFLD and MetS, emphasizing their interconnected pathophysiology, clinical manifestations, and modern approaches to treatment and prevention. The purpose of the study is to review the latest literature on NAFLD and MetS, focusing on the mechanisms linking these conditions, diagnostic criteria, and therapeutic strategies. Methods. A comprehensive review of relevant literature was conducted using databases such as PubMed, Scopus, Web of Science, and Google Scholar. We focused on publications from the last five years, selecting studies based on their relevance to NAFLD, MetS, pathophysiology, diagnostic approaches, and treatment strategies. A total of 80 articles, including metaanalyses, clinical trials, and systematic reviews, were included in the analysis. Inclusion criteria: evidence-based studies, clinical trials, systematic reviews, and meta-analyses. Exclusion criteria: expert opinions, editorial articles, and non-peerreviewed sources. Results. NAFLD encompasses a spectrum ranging from simple hepatic steatosis to non-alcoholic steatohepatitis (NASH), fibrosis, and ultimately cirrhosis. MetS is characterized by a cluster of risk factors that contribute to the development of cardiovascular diseases and type 2 diabetes. The two conditions share common risk factors such as insulin resistance, central obesity, and inflammation. Lifestyle modifications, including dietary changes and increased physical activity, remain the cornerstone of treatment. Pharmacological therapies, including pioglitazone, GLP-1 receptor agonists, and emerging drugs targeting fibrosis, offer additional therapeutic options. Bariatric surgery has shown promise in treating advanced stages of both NAFLD and MetS. Conclusion. This review underscores the critical need for early diagnosis, lifestyle interventions, and a multidisciplinary approach to the management of NAFLD and MetS. Further research into the molecular mechanisms and long-term outcomes of treatment options will be crucial in improving patient care and reducing the global burden of these conditions.
REVIEW OF PHYTOCHEMICAL COMPOSITIONS AND PHARMACOLOGICAL ACTIVITIES OF COUSINA CASS. SPECIES
Authors: Zhakupova A.S. , Makhatova B.G. , Datkhaev U.M. , Kusainov A.Z.
Published: January 2025

The genus Cousinia, comprising over 50 species, is widespread in Kazakhstan. However, the phytochemical composition and biological properties of many species remain underexplored. This study aims to summarize existing data on their pharmacological potential. Methods: Systematic, descriptive, and retrospective methods were employed for the analysis. Results: Studies have revealed that Cousinia species contain phytochemicals such as flavonoids, terpenoids, and alkaloids. These compounds exhibit antioxidant, anti-inflammatory, and antimicrobial properties. Endemic species of Kazakhstan, including Cousinia mindshelkensis listed in the Red Book, were specifically analyzed. Discussion: Further research on Cousinia holds significant potential for the development of new pharmaceuticals due to their rich phytochemical diversity.
INFLUENCE OF SOIL COMPOSITION ON THE MORPHO-ANATOMICAL STRUCTURE OF THE ALOE VERA PLANT
Authors: Imanova E.M. , Myrzabay A.B. , Tileubayeva ZH.S. , Aitzhanova M.O. , Kozhamzharova A.S. , Ablaikhanova N.T. , ZH B.A.
Published: January 2025

Aloe is a plant that resembles a cactus and flourishes in hot, dry areas. It is grown in subtropical climates all throughout the world, including the border regions of New Mexico, Texas, California, and Arizona in the south. In medical practice, medicinal raw materials from plants are currently used as biogenic stimulants. Aloe vera contains more than 200 biologically active natural ingredients, including polysaccharides, vitamins, enzymes, amino acids, anthraquinones, saponins, organic acids, phytoncides, esters, phenols, resins, minerals and other elements that promote the absorption of nutrients, improve the functioning of the digestive system, strengthen the immune system, and also cleanse the body of toxins. It contains 20 amino acids, including essential ones for humans. Aloe gel is a storehouse of antioxidant vitamins A, C, E and B vitamins. Eight extremely important enzymes for humans were also found in this plant. The mineral complex in aloe is represented by calcium, copper, selenium, chromium, manganese, magnesium, potassium, sodium and zinc. This article presents a comparative analysis of the morpho-anatomical features of aloe vera from aloe arborescens, and also conducts a study of the anatomical structure of the Aloe vera L. plant in 4 variants grown in soil, collected from various mixtures.
ПРОВЕДЕНИЕ МАКРОСКОПИЧЕСКОГО И МИКРОСКОПИЧЕСКОГО АНАЛИЗА КОРНЕЙ И КОРНЕВИЩ ТРАВЫ ПЫРЕЯ ПОЛЗУЧЕГО (ELYTRIGIA REPENS L.)
Authors: Конаш Н.Е. , Жакипбеков К.С. , Саякова Г.М. , Момбеков С.Е. , Тлеубаева М.И. , Дарапов Ш.С.
Published: January 2025

В статье представлены результаты макро- и микроскопического исследования особенностей анатомического строения (корня и корневища) пырея ползучего (Elytrigia repens L.). Изучение общих диагностических признаков анатомического строения и морфологические признаков растений позволяет определить их подлинность. Целью работы является изучение морфологического и анатомического строения подземных органов пырея ползучего для определения подлинности и отличия сырья от других видов. Материалы и методы: объект исследования – корневища и корни пырея ползучего, собранные в период цветения в предгорьях Западного ТяньШаня в мае-июне 2023 года. Изучение анатомических признаков пырея ползучего проводилось в соответствии с требованиями государственной фармакопеи Республики Казахстан. Исследование объектов проводилось с помощью микроскопа Биолам-5 с увеличением от х40 до х400. Исследование срезов и создание микрорисунков проводили с помощью цифрового камерного тринокулярного микроскопа «МТ300L» (Япония) (увеличенный 7х1,5х4,5; 7х1,5х8; 7х1,5х40). Результаты и обсуждение: для определения цельного сырья были изучены диагностические признаки: поперечный срез корня, форма клеток эпидермиса, строение волосков и слои камбия. Корнях и корневищах растения встречаются волоски и волокна, а именно, тканевые волокна и одноклеточные волоски. Заключения: проведен макром микроскопический анализ пырея ползучего. Для определения подлинности растительного сырья были выявлены морфологические и анатомо-диагностические признаки. Диагностические признаки сырья пырея ползучего (Elytrigia repens L.): наличие оксалатов кальция (друз) в корнях и корневищах. Соли оксалата кальция отчетливо видны в паренхиматозных клетках коры. Основным направлением развития отечественной фармацевтической отрасли является повышение удельного веса лекарственных средств, получаемых из лекарственных растений. С этой целью продолжается дальнейшее изучение растения пырея ползучего.
COMPARATIVE STUDY OF BIOCOMPONENTS OF AERIAL AND UNDERGROUND PARTS OF FERULA FOETIDA BY GAS CHROMATOGRAPHY-MASS SPECTROMETRY METHOD
Authors: Tolepberge A.A. , Minkayeva A.A. , Ye S. , Ya Z.U. , Shang X. , Jenis J.
Published: January 2025

Kazakhstan’s pharmaceutical industry is producing low amount of domestic medicinal products due to insufficient study of local medicinal plants as a drug source and high demand of these plants in foreign market. In this case, fundamental studies of endemic and medicinal plants are the highest of the priority for science of domestic pharmacy. Ferula foetida is a plant that combines various active substances with valuable biological activity. The plant has massive taproot or carrotshaped roots, 12-15 cm in diameter in the crown. It has several pharmacological activities like anti-flatulent, antibacterial, antiviral, antifungal, anti-ulcerogenic, antidiabetic and anti-hepatotoxic properties. This research work indicated the results of quantitative analysis of aerial and underground parts of Ferula foetida that include the compositional substituents of the main groups of bioactive substances. The phytoconstituents analysis was conducted according to the methodology of the State Pharmacopoeia of the Republic of Kazakhstan (Test methods of medicinal plant raw materials, Vol. 2). 11 macro- and micro-elements in the ash and plant were identified by atomic absorption spectrometry. Moreover, the chromatographic investigation of both parts that was done by gas chromatography with mass spectrometric detection (GC-MS) is presented in the given research work. According to GC-MS results, there were found 47 compounds in the underground part and 66 substituents in the aerial part of F. foetida. Based on the conducted analyses, it can be concluded that the phyto-composition of the plant is a rich source of biologically active complexes with promising and beneficial effects in the consistency of future medicinal product. This study of the F. foetida plant continues to do in-depth research on the chemical composition and biologically active substances of both parts.
EXPERT COUNCIL: TOPICAL ISSUES OF DISEASES OF THE UPPER GASTROINTESTINAL TRACT
Authors: Kaibullayeva D.A. , Kaliaskarova K.S. , Dzhumabaeva A.E. , Tanabaeva A.S. , Kaisina A.A. , Alimbetova M.S. , Laryushina E.M. , Muldasheva P.A. , Doszhan A. , Kravtsova E.V. , Bekisheva A.N. , Kushimova D.E.
Published: January 2025

The purpose of this Expert Council is to assess the current situation in the diagnosis, treatment and prevention of gastroesophageal reflux disease and its complications, providing up-to-date data based on the latest world recommendations and practical advice developed during the Expert Consensus process. Taking into account the contribution of upper gastrointestinal tract pathology to the overall structure of gastrointestinal cancers, there is a need to provide recommendations for the management of this category of patients by gastroenterologists, primary care physicians and other involved specialists to prevent dysplasia and malignization of gastroesophageal reflux disease. Methods: The best practice recommendations presented here have been developed based on a combination of available evidence from the published literature and Expert Consensus. No formal assessment of the strength or quality of the evidence has been made. The purpose of this article is to provide practical advice to primary care physicians as well as gastroenterologists and allied professionals in the Republic of Kazakhstan.
The Effect Telemonitoring for Preventing 30 Days Re- Admission Among Heart Failure Patients : A Systematic Review
Authors: Amalia Irma Nur , Said Faridah Binti Mohd , Nambiar Nisha
Published: January 2025

Introduction: The increasing morbidity and mortality rates of Heart Failure (HF) patients require a comprehensive treatment. The high re-hospitalization or re-admission rate also has a major impact on the entire health system. Remote monitoring for HF patients using Tele-monitoring has been proposed to reduce the burden of re-admission and health costs for patients. Although Tele-monitoring utilization remains limited in several developing countries.

Objective: This study described how to implement effective Telemonitoring for preventing 30 days readmission rate after patient discharged from Hospital.

Method: Databases were collected from Science Direct, ProQuest, EBSCO, BMJ, Research Gate, Google Scholar articles publication between 2019-2022 and selected based on compatibility with keywords. All RCTs or Quasi Experiment Study with HF adult patients were included and sixteen unique articles were included.

Result: From the results of the articles, it is known that telemonitoring for HF patients not only affects 30 days readmission but also has a direct impact on the level of self-care and quality of life patients. Telemonitoring models complete with symptom sign detection are considered a good anticipation of the worsening condition of HF patients.

Conclusion: This systematic review is expected to develop an effective telemonitoring model for preventing 30 days readmissions among HF patients.
Mr A Neural Network-Based Study on the Significance of Risk Aversion Bias in Life Insurance Selection.
Authors: Engti Mr. Hunasing , Bhowal Prof. Amalesh
Published: January 2025

Risk aversion bias, a significant behavioural factor, often causes individuals to make financial choices that diverge from optimal decision-making strategies. The present study is to examine the impact of risk aversion bias on insurance selection decisions by leveraging the predictive power of neural networks. The research utilizes a dataset that includes demographics, latent variables of risk aversion bias, and preference-based variables (binary). It employs a neural network model to assess the extent to which risk aversion bias influences insurance product selection. The study also used bootstrapping analysis to validate the application of the neural network model in small-sample research. The methodology encompasses data preprocessing, model training, and validation to ensure the robustness of the results. Results show evidence that risk aversion bias acts as a major influencing factor in shaping the insurance selection decision, with notable variations across demographic groups. Moreover, when compared to traditional methods, the neural network approach shows superior performance in statistical models and has the capacity to effectively capture the complex, non-linear relationships within behavioural data. Findings from this analysis add meaningful value to the areas of behavioural finance in general and insurance decision-making in particular, providing actionable guidance for insurance providers to tailor their products and strategies in line with consumer biases. The study also highlights neural network potential to improve understanding of the behaviour of life insurance consumer and proposes future research to broaden the model's applicability.
Lessons learned from conducting a serological survey for Japanese encephalitis after detecting the first cases in New South Wales, Australia, 2022
Authors:   Master of Philosophy in Applied Epidemiology Programme, National Centre for Epidemiology and Population Health, The Australian National University, Canberra, Australia, Baldwin Zoe ,   Department of Health Protection, Hunter New England Local Health District, Newcastle, New South Wales, Australia, Davies Sarah ,   NSW Public Health Training Program, NSW Ministry of Health, St Leonards, New South Wales, Australia, Hope Kirsty ,   NSW Ministry of Health, St Leonards, New South Wales, Australia, Case Jennifer ,   NSW Ministry of Health, St Leonards, New South Wales, Australia
Published: January 2025

Problem: The first known locally acquired cases of Japanese encephalitis virus (JEV) infection in New South Wales (NSW), Australia, were identified in March 2022. NSW Health (the state entity for health care in NSW), with its partner agencies, conducted a serological survey to identify the prevalence of JEV antibody responses in high-risk communities in NSW.

Context: JEV infection is rare in Australia; therefore, vaccination is not recommended for the majority of Australians. Less than 1% of JEV infections in humans result in clinical disease.

Action: We conducted a cross-sectional serological survey of all age groups in five townships within NSW between June and July 2022. A summary report of the serosurvey methods and results was previously published by NSW Health. In this report, we describe the operations and lessons learned from rapidly gathering serological survey evidence to inform the public health management of JEV infection in NSW, within a country with well established health infrastructure.

Lessons learned: Resource limitations had to be addressed pragmatically during this field epidemiology research. Community participation varied between towns. The knowledge of local public health staff was important for identifying appropriate locations for clinics and community engagement activities. The consistency of data collection needs to be emphasized when multiple teams are involved. Data quality assurance issues were limited during this survey, owing to ease of communication in the field with the coordinating research team. When possible, allowing additional time for community engagement and staff orientation would be beneficial before implementing a similar survey. Further consideration of reporting serology results during the study design stage might have prevented the need for manual processing upon study completion.

Discussion: This serological survey highlights that a well trained and coordinated public health workforce can provide important, timely evidence when faced with an emerging public health issue.
Sistematización de experiencias con estudiantes de grado en prácticas y pasantías
Authors: González Castro Elda , Esquivel Quezada Jorge Luis , Lacayo Romero Martha Lorena
Published: January 2025

El Centro de Investigación en Biotecnología de la Universidad Nacional Autónoma de Nicaragua, Managua (CIB/UNAN-Managua) ha venido implementando diferentes estrategias en los  procesos de formación a través de las prácticas y pasantías que realizan los estudiantes que cursan los años III, IV y V de las carreras afines a la Biotecnología, durante el período de 2019-2023. El objetivo del proceso de sistematización de la experiencia fue exponer la metodología que contribuyó al mejoramiento y transformación de los procesos educativos a través de las prácticas y pasantías, así como el reconocimiento de la labor de los estudiantes. Se contabilizaron 280 estudiantes en el período evaluado. La mayoría de los estudiantes atendidos corresponde a la carrera de Química Ambiental, Química Industrial y Biología del Departamento de Ciencias Básicas y Tecnología de la UNAN-Managua. Las prácticas que predominaron fueron las de familiarización con un 28% del total. La práctica de familiarización son una parte fundamental en el avance profesional de los jóvenes, y la forma en que se  desarrollan es el aprendizaje principal en la docencia del CIB/UNAN-Managua, por lo que la experiencia vivida nos permite mejorar nuestra acción para hacerla transformadora y dar a conocer a detalle datos que evidencian el trabajo docente en el CIB/UNAN-Managua. Se hizo énfasis en las áreas de oportunidades del estudiante para crear con profesionales exitosos que cumplan y se adaptan a las exigencias de un mundo laboral competitivo.
Método de evaluación básica del manejo de residuos sólidos en áreas urbanas turísticas de Nicaragua
Authors: López Guevara Henry , Leets Layo , Ribera Rubén
Published: January 2025

Este artículo presenta un método para la evaluación básica del manejo de residuos sólidos en áreas urbanas de interés turístico en Nicaragua, aplicable a calles, parques, malecones y otros sitios públicos. El método se basa en dos variables: la Cantidad Óptima de Depósitos (COD), que se evalúa en relación con el área o longitud del sitio, y el nivel de contaminación presente en el mismo. Estas variables se combinan en un modelo lógico sumativo con el cual se obtiene una interpretación del manejo en la escala de inapropiado, no adecuado, adecuado y eficiente. El método fue aplicado en 35 sitios turísticos de Nicaragua, distribuidos entre las ciudades de Masaya, Granada, San Juan de Oriente y Tola. El método fue validado mediante un análisis de  correspondencia simple utilizando el software SPSS. Los resultados muestran que el método es eficaz para evaluar la eficiencia del manejo de residuos sólidos y puede ser una herramienta útil para planificadores urbanos y gestores de residuos en áreas turísticas. Este trabajo propone un enfoque práctico y replicable para mejorar la sostenibilidad del turismo urbano mediante el manejo adecuado de los residuos sólidos.
Crítica a la satisfacción estudiantil como parámetro de calidad en la educación superior
Authors: Raza Carrillo Diego , Carrillo Lanas Edison
Published: January 2025

El objetivo de este trabajo de investigación es presentar una crítica a la medición de la satisfacción estudiantil como un parámetro de calidad en la educación superior. La creciente mercantilización de la educación superior que, desde una lógica empresarial, ha llevado a la consideración del estudiante como un simple “cliente” es actualmente objeto de amplio cuestionamiento y aquello ha determinado el interés en este estudio
Cooperación Sur-Sur universitaria: una nueva forma de colaboración entre América Latina y África
Authors: HIRI Abdelhak
Published: January 2025

Tradicionalmente las universidades latinoamericanas y africanas cooperaron en forma asimétrica con un enfoque (Norte-Sur). El presente artículo es un trabajo elaborado según un objetivo claro que es examinar la cooperación universitaria Sur-Sur, con un sentido de horizontalidad, racionalidad y corresponsabilidad que anima a la apertura y al compartir. Para ello hemos tomado como estudio de caso la colaboración del Instituto Superior Internacional de Turismo de Tánger (ISITT) con la Universidad Santo Tomas de Chile (UST) y el Instituto Técnico Santo Tomas.  Este ejemplo constituye un modelo exitoso de cooperación entre las instituciones universitarias africanas y latinoamericanas. Nuestra investigación se enfoca en exponer cómo se ha llevado a cabo esta colaboración, qué beneficios ha traído para ambas partes y cómo ha contribuido al desarrollo y la internalización de la educación superior en ambos países.