bluuebunny/crossref_metadata_2025 huggingface dataset:
DESAFIOS À IMPLEMENTAÇÃO DE COMPRAS PÚBLICAS SUSTENTÁVEIS: UMA REVISÃO INTEGRATIVA
Authors: Demarchi Murilo Pedro , Guercio Mary Jerusa , Sierra Eduardo Juan Soriano
Published: February 2023

Em uma escala global, as compras públicas correspondem a cerca de 12% do PIB de uma nação. As compras públicas sustentáveis (CPS) compreendem as aquisições públicas que adotam critérios de sustentabilidade nos processos licitatórios. O presente estudo buscou investigar, por meio de uma revisão integrativa, quais seriam os principais desafios existentes no setor público que dificultam a adoção das práticas de CPS. Os resultados apontaram para desafios vinculados ao grau de desenvolvimento econômico dos países e, também, para um determinado nível de desenvolvimento. Observou-se que o conhecimento limitado dos atores nas compras, a ausência de liderança e a falta de dados e de monitoramento sólidos são considerados fatores cruciais para o aprimoramento desta modalidade de compra, relacionada à meta 12.7, do objetivo 12, da Agenda 2030 da ONU.
RECURSOS AUDIOVISUAIS E EDUCAÇÃO DIGITAL: DESENVOLVIMENTO DE OBJETOS DE APRENDIZAGEM PARA A AGENDA 2030 A PARTIR DA METODOLOGIA DE APRENDIZAGEM
Authors: Schimmelpfeng Leonardo Enrico , Dos Santos Pacheco Roberto Carlos
Published: February 2023

O presente trabalho apresenta uma proposta para a organização do Fluxo de Produção e de uma Taxonomia de Objetos de Aprendizagem (OAs) Audiovisuais para mobilizar os processos de ensino-aprendizagem dos Objetivos de Desenvolvimento Sustentável (ODS) da Agenda 2030 propostos pela ONU. Com base nos conceitos de Educação Digital, Neoaprendizagem e os Ambientes Virtuais de Ensino Aprendizagem (AVEAS), esta pesquisa  realizada como parte da pesquisa pós-doutoral, apresenta o como foi realizado o fluxo de produção de OAs e a criação da taxonomia de videos presentes no curso de Capacitação em Municipalização da Agenda 2030 do programa CEURS  - projeto desenvolvido em colaboração entre o EGC/UFSC e IEA/USP e a Câmara Federal.
Review on Pathology
Authors: Sanjay K. Bais  , Nilesh A. Raste
Published: February 2023

While red blood cell (RBC) transfusion is the most common medical intervention in hospitalized patients, as with any therapeutic, it is not without risk. Allogeneic RBC exposure can result in recipient alloimmunization, which can limit the availability of compatible RBCs for future transfusions and increase the risk of transfusion complications. Despite these challenges and the discovery of RBC alloantigens more than a century ago, relatively little has historically been known regarding the immune factors that regulate RBC alloantibody formation. Through recent epidemiological approaches, in vitro–based translational studies, and newly developed preclinical models, the processes that govern RBC alloimmunization have emerged as more complex and intriguing than previously appreciated. Although common alloimmunization mechanisms exist, distinct immune pathways can be engaged, depending on the target alloantigen involved. Despite this complexity, key themes are beginning to emerge that may provide promising approaches to not only actively prevent but also possibly alleviate the most severe complications of RBC alloimmunization
Editorial / Manifesto
Authors: Roberto da Silva Mauricio , De Lorenzi Pires Giovani , Roberto da Silva Rogério
Published: February 2023

I) Em defesa da democracia: contra a violência política do terrorismo bolsofascista

II) O ouro de sangue Yanomami: contra a barbárie do genocídio dos povos originários
El modelo social de la discapacidad y la incompatibilidad de aplicar la medida de seguridad de internamiento para la persona en situación de inimputabilidad
Authors: Fernández Espinoza William Homer
Published: February 2023

El presente trabajo de investigación estudia el problema de la aplicación judicial de la medida de seguridad de internamiento para la persona en situación de inimputabilidad, debido a que en el ordenamiento jurídico penal persiste el modelo rehabilitador frente al modelo social dispuesto en la Convención sobre los Derechos de las Personas con Discapacidad. Para su desarrollo, se analizan la doctrina, las normas y la jurisprudencia nacional e internacional, a fin de proponer una reforma legislativa para garantizar la protección integral de los derechos humanos de las personas con discapacidad mental.
KẾT QUẢ SỚM PHẪU THUẬT SỬA TOÀN BỘ ĐIỀU TRỊ THÔNG SÀN NHĨ THẤT BÁN PHẦN Ở NGƯỜI LỚN TẠI BỆNH VIỆN BẠCH MAI GIAI ĐOẠN 2018 – 2021
Authors: Ma Nguyễn Thái Hoàng , Dương Đức Hùng , Phạm Quốc Đạt , Vũ Ngọc Tú
Published: February 2023

Mục tiêu: Đánh giá một số đặc điểm lâm sàng, cận lâm sàng và kết quả sớm phẫu thuật sửa toàn bộ thông sàn nhĩ thất bán phần ở người lớn tại bệnh viện Bạch Mai giai đoạn 2018 – 2021. Đối tượng và phương pháp nghiên cứu: Nghiên cứu mô tả, hồi cứu các bệnh nhân thông sàn nhĩ thất bán đã được phẫu thuật sửa toàn bộ từ tháng 6/2018 đến tháng 12/2021 tại bệnh viện Bạch Mai. Kết quả: Nghiên cứu có 29 bệnh nhân, 12 nam và 17 nữ. Tuổi trung bình là 39 ± 13 tuổi (từ 18 tới 61 tuổi). Triệu chứng suy tim: NYHA II (82.8%), NYHA III (6.9%), NYHA IV (3.4%). 1 trường hợp loạn nhịp hoàn toàn trước mổ (3.4%). Kết quả siêu âm tim: Tổn thương hở van hai lá mức độ vừa và nặng có 21 bệnh nhân (72.4%), hở ba lá vừa và nặng 26 bệnh nhân (89.7%). Tăng áp lực động mạch phổi là: nhẹ (41.4%); vừa (48.3%); nặng (10.3%). Kích thước lỗ thông liên nhĩ trung bình là 27 ± 11 mm (từ 8 tới 51mm). Thời gian trung bình: chạy tuần hoàn ngoài cơ thể: 85 ± 22 phút (45-130 phút), cặp động mạch chủ: 62 ± 15 phút (34-89 phút). Sau mổ: NYHA II (10.3%), không có NYHA III hay IV. Siêu âm tim: 34.5% hở van hai lá vừa – nặng. 3.4% hở van ba lá mức độ vừa, không có hở nặng. 1 trường hợp còn hở hai lá nhiều sau mổ (3.4%) và cần phải can thiệp phẫu thuật lại. 2 trường hợp phải cấy máy tạo nhịp vĩnh viễn sau mổ (6.9%). Không có bệnh nhân nào tử vong hay có biến chứng nặng khác. Kết luận: Phẫu thuật sửa toàn bộ thông sàn nhĩ thất bán phần ở người lớn tại Bệnh viện Bạch Mai được thực hiện an toàn, có kết quả sớm và tỷ lệ biến chứng sau phẫu thuật tương đương với các tác giả khác.
NGHIÊN CỨU TỶ LỆ TAI BIẾN, BIẾN CHỨNG CỦA TÁN SỎI QUA DA ĐƯỜNG HẦM NHỎ ĐIỀU TRỊ SỎI THẬN TÁI PHÁT
Authors: Nguyễn Minh An , Bùi Hoàng Thảo
Published: February 2023

Mục tiêu nghiên cứu: Nghiên cứu tỷ lệ tai biến, biến chứng của phương pháp tán sỏi nội soi qua da đường hầm nhỏ điều trị sỏi thận tái phát. Phương pháp nghiên cứu: Mô tả cắt ngang. Kết quả nghiên cứu: biến chứng trong mổ gặp 5 bệnh nhân, trong đó có 3 bệnh nhân có chảy máu phải truyền máu trong mổ (chiếm 4,0%) và 2 bệnh nhân chuyển mổ mở (chiếm 2,7%). Tỷ lệ biến chứng sau tán sỏi là 17,3%, trong đó có 3 bệnh nhân có sốt sau phẫu thuật và 1 bệnh nhân tụt dẫn lưu (chiếm 1,3%) và 7 bệnh nhân có biểu hiện chảy máu thứ phát sau phẫu thuật (chiếm 9,3%). Tỷ lệ biến chứng phân loại Clavien – Dindo: độ I là 11/75 bệnh nhân (chiếm 14,7%), biến chứng độ II là 2 bệnh nhân (chiếm 2,7%). Kết luận: Kết quả nghiên cứu cho thấy, tán sỏi nội soi qua da đường hầm nhỏ là phương pháp an toàn và hiệu quả trong điều trị sỏi thận tái phát với tỷ lệ tai biến trong phẫu thuật là 5/75 bệnh nhân (chiếm 6,7%). Tỷ lệ biến chứng sau phẫu thuật là 13/75 bệnh nhân (chiếm 17,3%)
THỰC NGHIỆM ĐO GÓC NGHIÊNG Ổ CỐI VÀ PHƯƠNG PHÁP ĐIỀU CHỈNH ĐỂ ĐẠT GÓC NGHIÊNG MỤC TIÊU TRÊN MÔ HÌNH SAWBONE NỬA KHUNG CHẬU NGƯỜI TRƯỞNG THÀNH
Authors: Bùi Đức Ngọt , Trần Xuân Lộc , Đào Xuân Thành
Published: February 2023

Nghiên cứu thực nghiệm trên mô hình sawbone nửa khung chậu người trưởng thành, tỷ lệ 1:1 để thực nghiệm đo góc nghiêng ổ cối và phương pháp điều chỉnh để đạt góc nghiêng mục tiêu. Kết quả: thời gian đo cOI, OA và AI trung bình 8,49; 8,39 và 7,87 giây. Sai số của góc đặt OI và OA so với góc mục tiêu là 2,230 và 1,730, có sự khác biệt có ý nghĩa thống kê với p < 0,05, độ tin cậy 95%; 6/25 góc RI và 4/25 góc RA nằm ngoài khoảng an toàn Lewinnek, xảy ra khi góc đặt quá nhỏ hoặc quá lớn. Thực hiện 26 lượt điều chỉnh góc OI và 39 lượt góc OA để đạt góc RI và RA mục tiêu. Sai số RI và RA sau điều chỉnh lần lượt là 0,470 và 0,240, không có sự khác biệt với p> 0,05, độ tin cậy 95%. Kết luận: Khung định vị ổ cối của hãng thiếu độ ổn định và độ chính xác không cao. Việc thực hiện đo góc OI qua góc phụ của nó với phương thẳng đứng và góc AI có độ tin cậy cao nhất. Qua việc tính toán dựa trên giá trị 2 góc này, có thể điều chỉnh góc nghiêng ổ cối về rất gần giá trị mục tiêu một cách đơn giản và hiệu quả.
ĐẶC ĐIỂM LÂM SÀNG, CẬN LÂM SÀNG CỦA TRẺ MẮC HỘI CHỨNG NGỪNG THỞ KHI NGỦ DO TẮC NGHẼN CÓ AMYĐAN - VA QUÁ PHÁT
Authors: Phí Thị Quỳnh Anh , Đào Hoa Phượng , Lê Khánh Chi , Trần Thị Hương Thảo , Bùi Thị Bảo Ngọc , Đinh Thị Mai Loan , Nguyễn Thị Trà Giang
Published: February 2023

Tổng quan: Hội chứng ngừng thở tắc nghẽn khi ngủ (Ostructive sleep apnea syndrome: OSAS) ở trẻ em gây hậu quả nghiêm trọng và lâu dài: chậm phát triển về tâm sinh lý, giảm khả năng học tập và trí nhớ, mắc chứng trầm cảm hay hiếu động quá mức, có thể gây đột tử khi ngủ. Có 80% đến 90% bệnh nhân mắc hội chứng này không được phát hiện và điều trị. Amyđan-VA quá phát là nguyên nhân hay gặp nhất gây ra OSAS ở trẻ em. Chúng tôi tiến hành nghiên cứu này với mục tiêu: mô tả đặc điểm lâm sàng, cận lâm sàng của trẻ mắc hội chứng ngừng thở do tắc nghẽn khi ngủ có amiđan-VA quá phát. Đối tượng và phương pháp: nghiên cứu quan sát, mô tả được thực hiện trên 114 ca trẻ có amiđan - VA quá phát được chẩn đoán OSAS tại bệnh viện nhi trung ương  từ T6/2017-T8/2019. Kết quả: Tuổi trung bình trong nhóm nghiên cứu là 5,5 tuổi, Tuổi thấp nhất là 2,5 tuổi và tuổi cao nhất là 12 tuổi. Bệnh nhân có chiều cao và cân nặng  trung bình là 113,9cm và 22,7kg với BMI trung bình 16,9 kg/m2. Lý do đi khám chủ yếu là ngủ ngáy và có cơn ngừng thở được chứng kiến.Triệu chứng thường gặp nhất là: ngủ ngáy (3,3), thở miệng (2,7). AHI trung bình là 12,6 ± 11,2 cơn/ giờ, ở mức độ nặng. Độ bão hòa oxy máu thấp nhất là 75,7 ± 13,7%. Kết luận: Ở bệnh nhân mắc OSAS có Amiđan và VA quá phát triệu chứng thường gặp nhất là ngủ ngáy, có cơn ngừng thở khi ngủ, ngạt tắc mũi, thở miệng. Chỉ số AHI trung bình là 12,6 ± 11,2 cơn/giờ ở mức độ nặng. Sự phối hợp giữa chỉ số ngừng thở, giảm thở và độ bão hòa oxy trong máu đóng vai trò quan trọng trong đánh giá mức độ nặng của bệnh và lựa chọn phương pháp điều trị
Corporate Strategy Analysis in Increasing the Value of the Firm through Mergers and Acquisitions in the Banking Sector (Case Study on the BCA Group)
Authors: Kautsar Muhammad , Merawaty Endang Etty , Bahri Syamsul , Sutawidjaya Ahmad Hidayat
Published: February 2023

This study aims to determine the company's strategy based on after experiencing corporate mergers and acquisitions, considering the value of the firm and the company's financial ratios in the financial industry sector (a case study on the BCA Group). Quantitative research is carried out by analyzing Financial Statements one year before and one year after the merger and acquisition corporate action is carried out which has been audited from 2018 to 2020. Qualitative research is carried out by conducting interviews with Bank BCA Senior Employees (20 years experience at BCA) and employees of the BCA Syariah business unit. Technical analysis of quantitative data using SPSS software, technical analysis of qualitative data is carried out using the Strength-Weakness-Opportunity-Threat (SWOT) matrix. The results showed that the value of the firm experienced the highest value when the merger and acquisition corporate action was carried out in that year. Quantitative analysis of financial ratios before and after the corporate action was carried out did not show significant results. The corporate strategy recommendation based on a comprehensive analysis of the company's current conditions and conditions is to determine the strategy aggressively, this is due to internal strength factors and existing opportunities that are expected to be maximized by the company. This strategy is intended to support an aggressive growth policy, this may be done because the company has opportunities and strengths so that it can take advantage of existing opportunities.
The Effect of Financial Knowledge and Materialism on Pension Fund Planning Behavior with Impulsive Buying as a Mediation Variable
Authors: Silvy Mellyza , Widyaningrum Betty , Sari Linda Purnama
Published: February 2023

The objective of this research is to examine the influence of financial knowledge and materialism on retirement planning behavior with impulsive buying as the mediation variable. The object of this study is the person or individual who manages family finances. These respondents were selected with the criteria of having a minimum income of 4 million rupias and having 2 years of experience in Surabaya, Gresik, and Sidoarjo. Based on these criteria, there are 321 selected respondents will be analyzed. The partial Least Square (PLS) Structural Equation Model was used to analyze the data. The results showed that financial knowledge has a significant positive effect on retirement planning behavior. But materialism has an effect that is not negative and insignificant to retirement planning behavior. The results also indicate that impulsive buying mediates the influence of materialism on retirement planning behavior
Interpretasi Narasi Ayat-Ayat Eskatologis Dalam Juz ‘Amma
Authors: Jamiatussoraya Jamiatussoraya
Published: February 2023

Al-qur’an berusaha menjelaskan atau mengemukakan bukti-bukti logis tentang adanya hari akhir berdasarkan keadilan, setiap perbuatan harus mendapatkan imbalannya. Tentang eskatologi merupakan upaya untuk menginformasikan kondisi moral masyarakat. Penerimaan akan kebenaran adanya hari akhir bukti wujud adanya keadilan Tuhan. Keyakinan terhadap kehidupan setelah mati dapat mendorong orang untuk berbuat kebajikan terhadap kehidupan setelah mati. Penulisan skripsi ini bertujuan untuk menjawab dua rumusan masalah, yaitu bagaimana gambaran umum narasi ayat-ayat Kiamat (eskatologis) dalam Juz ‘Amma dan bagaimana penafsiran ayat-ayat Kiamat (eskatologis) dalam Juz ‘Amma. Penelitian ini merupakan penelitian kepustakaan (library research), menggunakan metode deskriptif analisis yaitu mendiskripsikan atau memberi gambaran terhadap objek yang diteliti melalui data yang telah terkumpul. Sebagai hasilnya gambaran umum hari kiamat dalam juz amma di ungkapkan dengan ungkapan metafora dan sedangkan menurut beberapa mufassir seperti M.Quraish Shihab dan Muhammad Abduh  dalam menafsirkan ayat-ayat kiamat ada yang cenderung ke tekstual dan kontekstual.
Interannual variability in the ecosystem CO2 fluxes at a paludified spruce forest and ombrotrophic bog in the southern taiga
Authors: Mamkin Vadim , Avilov Vitaly , Ivanov Dmitry , Varlagin Andrey , Kurbatova Julia
Published: February 2023

Abstract. Climate warming in high latitudes impacts CO2 sequestration of the northern peatlands through the changes in production and decomposition processes. The response of the net CO2 fluxes between ecosystems and the atmosphere to climate change and weather anomalies can vary across forest and non-forest peatlands. To better understand the differences in CO2 dynamics at forest and non-forest boreal peatlands induced by changes in environmental conditions, the estimates of interannual variability in the net ecosystem exchange (NEE), total ecosystem respiration (TER), and gross primary production (GPP) was obtained at two widespread peatland ecosystems – paludified spruce forest and the adjacent ombrotrophic bog in the southern taiga of west Russia using 6 years of paired eddy covariance flux measurements. Both positive and negative annual and growing season air temperature and precipitation anomalies were observed in the period of measurement (2015–2020). Flux measurements showed that, in spite of the lower growing season TER (332±17 … 339±15 gC m−2) and GPP (442±13 … 464± 11 gC m−2) rates, the bog had a higher CO2 uptake rates (NEE was -132±11 … -108±6) than the forest, except for the warmest and the wettest year of the period (2020), and was an atmospheric CO2 sink in the selected years, while the forest was a CO2 sink or source, depending on the environmental conditions. Growing season NEE at the forest site was between -142±48 and 28±40 gC m−2, TER between 1135±64 and 1366±58 gC m−2, and GPP between 1207±66 and
1462±107 gC m−2. Annual NEE at the forest was between -62±49 and 145±41 gC m−2, TER between 1429±87 and 1652±44 C m−2, and GPP between 1345±89 and 1566±41 gC m−2, respectively. Under the anomalously warm winter conditions with sparse and thin snow cover (2019/2020), the increased daily GPP, TER, and net CO2 uptake at the forest was observed, while at the bog, the changes in CO2 fluxes between the warm and cold winters were not significant. This study suggests that the warming in winter can increase the CO2 uptake of the paludified spruce forests of the southern taiga in non-growing seasons.
Technical note: Statistical generation of climate-perturbed flow duration curves
Authors: Yildiz Veysel , Milton Robert , Brown Solomon , Rougé Charles
Published: February 2023

Abstract. Assessing the robustness of a water resource system's performance under climate change involves exploring a wide range of streamflow conditions. This is often achieved through rainfall-runoff models, but these are commonly validated under historical conditions with no guarantee that calibrated parameters would still be valid in a different climate. In this note, we introduce the first statistical generation method to produce a range of plausible streamflow futures that are coherent across the full range of hydrological conditions. It relies on a three-parameter analytical representation the flow duration curve (FDC) that has been proved to perform well across a range of basins of different climate. We rigorously prove that for common sets of streamflow statistics mirroring average behavior, variability, and low flows, the parameterisation of the FDC under this representation is unique. We also show that conditions on these statistics for a solution to exist are commonly met in practice. These analytical results imply that streamflow futures can be explored by sampling wide ranges of three key flow statistics, and by deriving the corresponding FDC to model basin response across the full spectrum of flow conditions. We illustrate this method by exploring in which hydro-climatic futures a proposed run-of-river hydropower plant in eastern Turkey is financially viable. Results show that contrary to approaches that modify streamflow statistics using multipliers applied uniformly throughout a time series, our approach seamlessly represents a large range of futures with increased frequencies of both high and low flows. This matches expected impacts of climate change in the region, and supports analyses of the financial robustness of the proposed infrastructure to climate change. We conclude by highlighting how refinements to the approach could further support rigorous explorations of hydro-climatic futures without the help of rainfall-runoff models.
Effect of Fe–Fe interactions and X-site vacancy ordering on the OH-stretching spectrum of foitite
Authors: Balan Etienne , Radtke Guillaume , Fourdrin Chloé , Paulatto Lorenzo , Horn Heinrich A. , Fuchs Yves
Published: February 2023

Abstract. The OH-stretching infrared absorption spectrum of a tourmaline sample close
to the foitite end-member is interpreted in the light of the density
functional theory (DFT) modeling of iron-bearing Y3Z6 clusters in
tourmaline. The iron-bearing clusters reflect the Al-rich and Na-deficient
character of foitite and contain either two Fe2+ and one Al3+ or
one Fe2+ and two Al3+ ions at the Y sites. The clusters are
embedded in a tourmaline host structure with dravite composition. For the
iron dimer models, the structural and vibrational properties corresponding
to the ferromagnetic (FM) or anti-ferromagnetic (AFM) arrangement of the
iron spins and the effect of vacancy ordering along the [001] axis are
considered. A significant difference in the relaxed structure of the FM and
AFM clusters is observed, stemming from the electron delocalization and
Fe–Fe bonding interactions in the FM cluster. These bonding interactions are
not allowed in the AFM cluster. In this case, the valence electrons with
opposite spins remain separately localized on the two Fe atoms. The AFM
configuration is more stable than the FM one in the theoretical models,
provided that the description of the on-site Coulomb repulsion in Fe(3d)
orbitals is improved within the DFT + U framework. Based on the theoretical
results, the two bands at 3630 and 3644 cm−1 in the vibrational spectra
of iron-rich and Na-deficient tourmalines are assigned to WOH groups
associated with YFe22+YAl3+ environments with an
AFM coupling of Fe ions and surrounded by one and two vacant X sites,
respectively. The two major VOH bands of the experimental spectrum are
interpreted on the same basis, and these interpretations are extrapolated to
Mn-bearing tourmalines.
Okullarda Kriz Yönetiminin İletişim Açısından Değerlendirilmesi
Authors: Serter Ali
Published: February 2023

Crises occur at unexpected times and can have negative effects on the organization. All institutions make various plans in order to survive the crisis periods in the most undamaged way. However, it is not possible to say that crisis management planning in schools is very effective compared to other institutions. Crises in Turkey are mostly overcome impromptu and schools do not feel the need to work more on this issue. However, a crisis prepared in advance will enable the institution to come out of the crisis with the least damage in terms of both material and moral losses and the reputation of the school. Especially in such situations, it is very important for the schools where the students who need guidance the most to inform their staff and teachers about crisis management and to be prepared for the crisis. The purpose of this research is to examine the importance of crisis management and communication in schools.
The Implementation of Solar-Wind Cascading Power Station in Bangladesh
Authors: Islam Saddamul , Tarique Mohammed
Published: February 2023

Energy insufficiency is disturbing the improvement of Bangladesh. Since the sun light is not available always and the breeze does not blow constantly, solar and wind power alone are weaker power sources. Coupling solar as well as wind power sources along with storage batteries making up the full duration of time in the absence of wind or sun light supplies a pragmatic shape of power generation. In Bangladesh, breeze is not available most of the places. Only in the coastal areas, wind is sufficient to produce electricity. However, sunlight is available all over the year here. Although solar and wind alone power station has installed here but solar-wind cascading power station has not been installed yet.
The Impact of Foreign Remittance on Labor Productivity: A Case of Pakistan
Authors: Sattar Nosheena , Sarwar Kiran , Sajjad Asma
Published: February 2023

This study attempts an empirical analysis of the effect of external remittance on labor productivity in Pakistan. This study used the time series data from 1975 to 2019. The Johanson co-integration approach and Trace and Maximum Lamda tests were used for economic analysis. The personal remittance, Gross  Fixed Capital Formation (GFCF), and Officially Exchange Rate (PER) depicted significant and positive relationships and Foreign Direct Investment (FDI) and Trade both variables show positive but insignificant impacts on labor productivity. This study suggests that government should provide incentives for transfer payments to overseas Pakistanis for enhancing the remittances.
Intercâmbio Acadêmico: conexões da Pedagogia da Alternância entre Europa e América Latina
Authors: Fedrigo Lariane
Published: February 2023

Essa obra é um registro de um intercâmbio acadêmico na França de uma estudante do Brasil.
Determination of Product Life Cycle (PLC) for Formulation of Marketing Strategy UD. Matt Coffee Bondowoso
Authors: Pritantiwi Sonnia , Fatimah Feti , Hermawan Haris
Published: February 2023

UD Matt Coffee is an agroindustry that produces various processed coffees, including green beans, roasted coffee, and ground coffee. Owner of UD. Matt Coffee took the initiative to establish this agro-industry to improve the welfare of smallholder coffee farmers in Sumberwringin District because the trading process for green bean is considered unprofitable and does not yet have added value. This study aims to determine and analyze the position of UD. Matt Coffee Arabica Coffee products uses a Product Life Cycle (PLC) approach based on the Polli and Cook method and to determine and analyze marketing strategies in developing its business based on the Product Life Cycle (PLC) for UD. Matt Coffee Arabica Coffee products. The analytical method used in this study is the Polli and Cook method to determine the position of UD. Matt Coffee Arabica Coffee products based on the product life cycle. The data collection technique used interview techniques with resource persons, namely the owner of UD. Matt Coffee. The results showed that at the growth stage through the Product Life Cycle approach at UD. Matt Coffee Bondowoso. The growth stage is characterized by rapid market acceptance and a substantial increase in UD. Matt Coffee Bondowoso’s profits and research results also show that the strategy adopted by UD. Matt Coffee Bondowoso in accordance with its position in the product life cycle, namely UD. Matt Coffee Bondowoso is looking for innovative strategies to maintain and even increase sales growth which includes market, product and marketing mix modifications.

 Keywords: Marketing, Product Life Cycle (PLC), Strategy.
Microfinancing and Poverty Alleviation: A Case of Advans Savings and Loans Limited in Sunyani
Authors: Bawa Mahi , Opoku Oscar Agyemang
Published: February 2023

The study examined the effect of microfinance on poverty alleviation in Sunyani Municipal using Advans Savings and Loans Limited. The study employed descriptive survey of the quantitative approach. Convenience sampling was used to select 243 respondents to form part of the study. Questionnaire was used as a data collection instrument to solicit for data from the market operators. The data gathered from the respondents were analyzed descriptively using frequencies, percentages and means as well as paired sample t-test with the aid of Statistical Package for Service Solution software version 21.0. The study found that household’s income, agribusiness, productivity and paying of utility bills have been improved after the introduction of microfinance service. Households’ daily savings, frequent of savings, and amount of savings have been improved subsequently after accessing microfinance products. There has been an improvement in the acquisition of assets after households started to patronize microfinance services. Respondents’ livelihoods have been influenced positively. There has been an appreciable improvement in financial, human and physical assets but little influence on natural and social assets. Therefore, the study recommended that microfinance should develop and improve upon packages and products for households in order to improve upon their income levels as well as acquisition of basic household assets. Moreover, households should be sensitized and educated on the essence of investing in social assets as well as social assets in the society.
The Impact of Facilities and Means of Transportation on Tourist Satisfaction at Monaco Park Sibiru-Biru Deli Serdang North Sumatra
Authors: Sitepu Gloria Citra Christiany Br , Syamsuri Abd. Rasyid , Hadian Arief
Published: February 2023

This study aims to analyze the effect of facilities and means of transportation on tourist satisfaction at Monaco Park Sibiru-Biru Deli Serdang, North Sumatra. The research method used in this research is quantitative. The research population is tourists in Monaco Park Biru-Biru, namely 300 visitors from January - March 2022. To determine the sample size of the known population, there are 300 tourists in Monaco Park Biru-Biru. With an error tolerance of 5%, the number of samples that will be used if calculated using the formula is 172 respondents. The results of the study show that facilities have a positive and significant effect on tourist satisfaction in Monaco Park Sibiru-Biru. Means of transportation have a positive and significant effect on tourist satisfaction in Monaco Park Sibiru-Biru. Simultaneously facilities and means of transportation have a positive and significant effect on tourist satisfaction in Monaco Park Sibiru-Biru. R Square (R2) shows the coefficient of determination is 0.719 (71.9%) meaning that the percentage of facilities, transportation facilities, and tourist satisfaction is 71.9% while the remaining is 28.1%.
CONVENTIONAL RESULTS OF UNCONVENTIONAL MONETARY POLICY
Authors: Khidasheli Mirza
Published: February 2023

The financial crisis of 2008 was a major crisis after 1929. It reminded once again us about the contradictory nature of fractional reserve Banking. The Great Depression taught us that the financial crisis of 2008 would result in a substantial reduction in economic activity and a sharp deterioration of key economic indicators. To "avoid" recessionary risks, the Federal Reserve System and other central banks of developed countries actively adopted monetary easing measures. A large amount of money was injected into the credit system. At the initial stage, the "explanation" of the mentioned measure was liquidity and recession risks. However, the time has shown us that the number of “colored papers" does not create wealth, it only distributes it in favor of those who have the privilege to "spend" it first, until a quantitative increase of money will be reflected in prices. As expected, the unconventional monetary policy gave very conventional results: inflation, stagnation, and an overheated credit system. The results would be more unambiguous without the Russia-Ukraine war, which affected inflation in the EU. The results of the monetary experiment conducted after the financial crisis of 2008 and its consequences, once again showed us that finance does not create wealth, it only promotes, distributes, and insures it. Therefore, every attempt to improve the picture of the real economy with monetary interventions is futile and cannot change the final result. With monetary interventions, it is only possible to postpone the consequences of the crisis, at the expense of their aggravation and intensification.
Miért vagy itt? Az egyházak képviselőinek diaszpóra-tapasztalata a szekuláris egészségügyi intézményekben
Authors:   Universitatea Babeş-Bolyai, Pál-Jakab Orsolya
Published: February 2023

First, we examine the diaspora experience of church representatives working in secular health care institutions within the context of hospital pastoral care. In the second part, we discuss the negative and positive aspects of this experience, with a special focus on the work of Catholic hospital pastoral caregiver in the Transylvanian region. The theoretical research questions were explored through primary and literature document analysis. The characteristics of the concept identified by Robin Cohen were then juxtaposed with a phenomenological analysis of the diaspora experience of hospital chaplains, and pastoral caregiver. Following Hauerwas, we can recognize the diasporic experience of churches in western secular societies. This phenomenon can be paralleled with the inadequacy of hospital pastoral care in secular health care institutions. The negatives of the diaspora experience include that the field of hospital pastoral care still searching for its place and there are many unanswered questions related to it. The phenomenon also has positive effects: stimulating inter-religious solidarity and shaping the Church's image according to Pope Francis' ecclesiological vision.
Is Single Forecast Method Better than Combined Forecast Method?
Authors: C.I. Ugoh , T.O. Chukwuemeka , E.O. Jophet , O.O. Pamela
Published: February 2023

Many studies have been done to prove that combining forecast methods gives a better predictive performance relative to individual forecasts. This paper compared the single forecast method and the combined methods in predicting time series data. The study used annual oil revenue for the period 1981–2019 from the Central Bank of Nigeria (CBN), which were divided into two sets: the Training Set (TS) which covered the period 1981–2010 and the Test Set (VS) which covered 2011–2019. The study adopted autoregressive integrated moving average (ARIMA), simple exponential smoothing (SES), and Holt’s linear trend (Holt) as the individual forecast methods; it also adopted outperformance of forecasts (OPF) and weighted mean (WM) as weight selection methods. The forecast methods were applied to the Training Set after which they were combined. Two combined methods CM1 (ARIMA + SES) and CM2 (ARIMA + SES + Holt) were obtained. The result of this study showed that simple exponential smoothing (SES) as an individual forecast method is better and less risky than the combined methods for forecasting time series.
Tilde-gamma-open sets and (Tilde-gamma , Tilde-beta)-continuous mappings
Authors: Saravanakumar Dhanabal , Mohamed Riyazdeen M.
Published: February 2023

In this paper, we introduce a new class of open sets namely tilde-gamma-open sets in a topological space. In addition, we define tilde-gamma-Ti (i = 0; 1/2; 1; 2) spaces, (tilde-gamma , tilde-beta)-continuous mapping and study their basic properties.
Potential of Anadara granosa Nanoparticles to improve the Expression of the Fibroblast Growth Factor-2 (FGF-2) in Chronic wound of Hyperglycemia conditions
Authors: Indah Budhy Theresia , Pudji Rahayu Retno , Ariestia Prathama Fata
Published: February 2023

Background: Hyperglycemia can cause adverse effects in the oral cavity, one of which is inhibiting wound healing. Chronic hyperglycemia reduces the expression and distribution of growth factors, such as fibroblast growth factor-2 (FGF-2), a significant growth factor in angiogenesis. The disruption of wound healing may lead to chronic wounds to further infection. Routine oral wound treatment using topical steroid ointment is considered ineffective in hyperglycemic individuals due to its anti-angiogenic properties. Anadara granosa shell nanoparticles can induce the production of numerous growth factors such as FGF-2 and augment angiogenesis. Objective: To determine the potential of giving Anadara granosa shell nanoparticles to increase FGF-2 in chronic inflammatory wounds with hyperglycemia conditions. Discussion: Angiogenesis supports and intersects with other ongoing proliferative activities and with the remodeling phase. FGF-2 helps the proliferation of endothelial cells and the arrangement of endothelial cells to form a tube to help angiogenesis. Hyperglycemia is directly associated with a significant reduction in FGF-2-induced angiogenesis in vivo. Biogenic CaCO3 nanoparticles made from Anadara granosa have shown promising potential to increase FGF-2 by activating NF-κB signaling. Conclusion: Anadara granosa shell nanoparticles have the potential to increase the expression of fibroblast growth factor-2 (FGF-2) in chronic inflammatory wounds with hyperglycemia conditions.
RP-HPLC Method Development and Validation for Simultaneous Estimation of Thymol, Eugenol and Alliin in Bulk and Novel Nanoformulation
Authors: Khristi Avani , Lata Jha Lalit , Dharamsi Abhay
Published: February 2023

A rapid and simple HPLC method was developed to detect and quantify Thymol, Eugenol and Alliin being the potential components of Ajwain oil, Clove oil and Garlic oil respectively in herbal formulation. Liquid chromatography with a UV detector at a wavelength of 278nm, using a C18 column, was employed in this study. Isocratic elution was employed using a mixture of acetonitrile: methanol:10mM Phosphoric acid buffer (50:25:25, v/v, pH 3.0). The analytical method validation was performed in accordance with ICH guidelines, which included selectivity, range, linearity, accuracy, detection limit, quantitation limit, precision, robustness, and stability of solutions. Acceptable assay precision and accuracy (100±2.0%) were obtained at 50– 150% of the analytical concentration of Thymol, Eugenol and Alliin at the target concentration, and good linearity (0.999, 0.998 and 0.998 respectively) were achieved over a range of 10µg/mL -60µg/mL for Thymol and Eugenol and 0.25µg/mL –1.50µg/mL for Alliin. The proposed HPLC method proved to be reliable. The validation and application of this method can be adopted and used in the pharmaceutical industry for routine analysis.
A Pilot Study on Knowledge and Experience on use of Generic Medicines among Healthcare Professionals
Authors: Kumar Gupta Vinay , Singh Amit , K. Gupta Ajay , Trigunayat A. , Kumar B.
Published: February 2023

Those medicines which are having same efficacy as that of their branded and expensive counterparts are known as Generic medicines. Compare to branded medicines, generic medicines have similar route of administration, indication, side effects, strength. Contrary to lower price and affordability the generic medicines are not so popular among healthcare professionals. The objective of this study is to analyse, knowledge and experience on use of generic medicines among healthcare professionals. A pilot study was conducted at Institute of Medical Sciences (IMS) Banaras Hindu University Varanasi India. This was a questionnaire-based cross-sectional study. The participants were doctors, nurses, pharmacists and others (research scholars and PG students). Chi square test used to find out p value. The overall response rate was 84.61 percent (55/65). Among all participants 12.7 percent did not “heard about Pradhan Mantri Jan Aushadhi Pariyojana Kendra”. Among all participants only 40 percent were not aware about Pradhan Mantri Jan Aushadhi Pariyojana Kendra situated in their area. Among all participants 72.73% aware about safe generic medicines, while among participant groups 60% of participating doctors, all nursing and pharmacy professionals and 72% of others accepted that generic medicines are safe as like branded medicines. A variation observed in respect of knowledge, and experience on generic medicines among participants. 40% (percent) of participating doctors did not believe in generic medicines and opted that the generic medicines are not safe as like branded medicines. Therefore, need for more training/awareness programmes on generic medicine arises. Need for building trust among healthcare professionals on generic medicines required.
Pengaruh Budaya Organisasi, Motivasi, dan Gaya Kepemimpinan Terhadap Kinerja Pegawai Pada Dinas Penanaman Modal dan PTSP Kabupaten Buleleng
Authors: Sudibia I Nyoman , Suci Made , Sayang Telagawathi Ni Luh Wayan
Published: February 2023

Kinerja ialah sebuah pencapaian hasil pekerjaan yang diraih seseorang disesuaikan pada tugas serta peran yang dihubung-hubungkan dengan standar kerja. Indikator penilaian pegawai adalah nilai SKP dan nilai perilaku kerja yang dievaluasi dengan harapan akan menunjukkan peningkatan setiap periode penilaiannya, sehingga dapat menunjang kinerja organisasi secara keseluruhan. Fenomena yang terjadi pada DPMPTSP Kabupaten Buleleng bahwa kinerja pegawai mengalami penurunan dari tahun 2019 – 2021 dengan melihat indikator nilai sasaran kerja pegawai. Studi berikut memiliki tujuan guna melihat keberpengaruhan budaya organisasi, motivasi, gaya kepemimpinan pada kinerja pegawai. Studi berikut dijalankan di Dinas Penanaman Modal dan PTSP Kabupaten Buleleng dengan populasi seluruh PNS sebanyak 33 pegawai. Teknik sampling yang dipilih ialah sampling jenuh yaitu semua populasinya dijadikan sampel. Mengumpulkan datanya dijalankan melalui sebaran angket untuk responden. Analisa datanya dijalankan mempergunakan analisa regresi linear berganda dibantu dengan program SPSS 26 for windows. Saat hendak menjalankan uji hipotesa, dijalankan lebih dulu instrument riset serta pengujian asumsi klasik. Temuan studi dinyatakan kalau budaya organisasi, motivasi dan gaya kepemimpinan secara parsial maupun simultan mempengaruhi kinerja pegawai.
The role of television drama in spreading security awareness
Authors: AbakerAbdullah Dr modwi
Published: February 2023

The aim of this study is to find out the effectiveness of the televised drama in the spreading of security awareness. The researcher used the transparent method (analytical method), the study reached some results: Sudanese televised drama is increasing societal security, seeking TV drama to deploy security awareness among the public addressing the issues related to societal security.

The televised drama contributes effectively to raise security awareness of the targeted audience by discussing social phenomenon in dramatic discourse, the researcher presented some recommendations as the need to promote security awareness among Sudanese televised channels to achieve the set purpose, the role played by media security should be encouraged and activated as specialized informative platform in security issues during crises, to be extended from the continues training of individuals working in the dramatic field on how to manage crises and disasters.
Herbs and dietary supplements in rheumatoid arthritis: The clinical evidence
Authors: Clement Yuri
Published: February 2023

Rheumatoid arthritis (RA) is an autoimmune disease that results in the destruction of joint cartilage and bone with an accompanying cluster of inflammatory symptoms leading to the progressive deformity of multiple joints. Several disease modifying anti- rheumatic drugs (DMARDs) are available for the treatment of RA (which arrest or slow disease progression); however, these are sometimes associated with severe side effects. The market is inundated with herbal preparations and dietary supplements are as beneficial to relieve symptoms in RA either as alternatives to or for use alongside conventional medicines. This mini-review sought to determine whether these therapies are safe and efficacious for the treatment of RA. The strongest clinical evidence exists for short-term complementary use of Tripterygium wilfordii Hook F “thunder god vine”, γ-linolenic acid and fish oils for symptomatic relief. However, no long-term studies support the use of these supplements to either arrest or delay disease progression. Only a few studies are available for saffron, cinnamon, ginger andpomegranate which are insufficient to establish safety and efficacy. Other studies have shown that integrating traditional Chinese medicine with western medicine may be beneficial; however, most of these studies were poorly designed. A few studies have shown that folic acid and folinic acid supplementation may reduce the incidence of methotrexate-induced side effects and prevent discontinuation. Conclusion There is limited and biased evidence regarding the efficacy of probiotics.
Anti-polysaccharide IgA seen to be more polyreactive than IgG antibodies
Authors: Reyes Díaz Laura
Published: February 2023

Polyreactive antibodies are natural antibodies. They bind with a low affinity to a variety of structurally unrelated antigens. IgA is the main antibody isotype that protects mucosal surfaces and can be produced against thymus-independent (polysaccharide) or thymus-dependent antigens (proteins). Nevertheless, the mucosal IgA polyreactive responses to polysaccharides are unknown. Neisseria meningitidis and Salmonella Typhi Ps were selected as the mucosal microorganisms. To explore the predominance of IgA over IgG isotypes in polyreactivity, a hybridoma system induced by polysaccharides was used. Mice were immunized with a standard protocol to produce monoclonal anti-Ps C from N. meningitidis and the Vi of S. Typhi antibodies. We used non-specific hybridoma supernatants to detect IgG and IgA anti A, C, Y, X, and Vi polyreactivity by indirect ELISA. Only one monoclonal antibody of nine secreting hybridomas in each system was obtained. Polyreactive responses against polysaccharides A, C, Y, and X of N. meningitidis and Vi of S. Typhi were obtained mainly from the IgA isotype. Only one polyreactive IgG was obtained from each system. Polyreactive anti-polysaccharide IgA responses predominate during hybridoma production and were found for the first time. The selection of polysaccharides as antigens for mucosal immunization could be a strategy to induce a polyreactive response.
The breastmilk as guardian of an immune treasure
Authors:   West Indian Immunology Society, Rodríguez-Pérez Leidiani
Published: February 2023

Breast milk is the most complete food for feeding neonates. In addition to its nutritional richness, it has multiple immune components that will participate both in the passive and active responses of the newborn and in the proper development and maturation of the immune system. Milk banks are institutions for collection, processing, and distribution of breast milk voluntarily donated to be used in cases where newborns cannot be fed by their own mother, at least during hospitalization period. This review aims to highlight the benefits of breast milk on the nutrition and maturation and functioning of the infant's immune system and therefore highlight the role of milk banks. The pasteurization process produces a decrease in the milk immune components, which is why these are kept in lower concentrations and still fulfill their functions in the newborn's immune system. The effect of this process on the cells of breast milk in newborns are not yet known.
環保型延期藥劑開發與特性分析
Authors: 林建宏 林建宏 , Jiann-Horng 邱柏文
Published: February 2023

本研究主要探討硼粉與氧化劑組成之延期藥的燃燒性能，氧化劑包括CuO及Fe2O3等兩種，再依不同重量比例規劃12個配方，另各配方外加1.5 wt％ Viton B作為膠合劑。

首先運用模擬軟體先期探討燃料與氧化劑的組成對燃燒熱力學參數之影響。其次利用熱分析技術，以微差掃描熱卡計量測延期藥的化學反應性能，建構不同組成配方起始反應溫度、反應熱及活化能。

製備實體延期藥柱，實際量測延期藥配方之最小點火能量，藥柱燃燒全程以高速攝影機拍攝，配合數位影片剪輯系統觀測燃燒現象並計算平均燃速，同時於石英管末端安置熱電偶量測延期藥輸出火焰溫度，最後建構不同組成配方的燃燒性能數據，據以評估各成分之重量比例改變對延期藥化學反應及燃燒性能之影響。

實驗結果顯示B/CuO延期藥具點火能量低、輸出火焰溫度高及平均燃速變異性大的燃燒特性，適合作為環保型延期藥配方。

 
Smile Preferences of Orthodontists and Patients from Frontal View about Gingival Display, Occlusal Cant and Smile ARC: A Study from Isra Dental College
Authors: . Mooli, , Samdani Sadia Asif , Siddiqui Sadaf
Published: February 2023

Objective: Was to determine preferences of orthodontists and patients about gingival display, occlusal cant and smile arc. Material and methods: This descriptive cross sectional study was conducted on 65 participants (15 orthodontists and 50 patients). The inclusion criteria were participants who gave consent, Pakistani nationals, age from 20 to 45 years, and Layperson/patients. Exclusion criteria were mentally retarded, uncooperative, color blinded individual and dental students, dental attendants and technicians. Adobe photoshop CS6 was used to alter the smile arc, occlusal plane and gingival display incrementally. Student t test was run to compare the smile preferences between orthodontists and patients. P≤0.05 was considered significant. Results: The mean age of the participants was 33.15±6.29 years. Females (n=38, 58.5%) were more than males (n=27, 41.5%). For 0mm gingival show the score assigned by laypersons (6.86±0. 756) was statistically higher than orthodontists (6.40±0.507) (P=.031). Gingival show of 5mm was less acceptable to laypersons (1.92±0.752) than orthodontists (3.27±0.594) statistically (P<0.001). Ideal smile arc was attractive for both laypersons (8.04±0.638) and orthodontists (9.33±0.724) but statistically more among orthodontists (P<0.001). Significant difference was found between perception of orthodontists and laypersons for normal smile (P=.034) and canted smile (P<0.001). Conclusion: Significant differences exist between opinions of orthodontists and laypersons in evaluating gingival display, smile arc and occlusal cant. Patient should be participated in treatment planning involving alteration of these smile parameters. Keywords: Smile perception, gingival show, smile arc, occlusal cant