bluuebunny/crossref_metadata_2025 huggingface dataset:
An analytical approach for unsupervised learning rate estimation using rectified linear units
Authors: Chen Chaoxiang , Golovko Vladimir , Kroshchanka Aliaksandr , Mikhno Egor , Chodyka Marta , Lichograj Piotr
Published: April 2024

Unsupervised learning based on restricted Boltzmann machine or autoencoders has become an important research domain in the area of neural networks. In this paper mathematical expressions to adaptive learning step calculation for RBM with ReLU transfer function are proposed. As a result, we can automatically estimate the step size that minimizes the loss function of the neural network and correspondingly update the learning step in every iteration. We give a theoretical justification for the proposed adaptive learning rate approach, which is based on the steepest descent method. The proposed technique for adaptive learning rate estimation is compared with the existing constant step and Adam methods in terms of generalization ability and loss function. We demonstrate that the proposed approach provides better performance.
Use of botulinum toxin in the management of dystonia in Parkinson’s disease
Authors: Anandan Charenya , Jankovic Joseph
Published: April 2024

Botulinum toxin is one of the most potent neurotoxins, but when injected into an overactive muscle, it can transiently alleviate an involuntary movement, such as dystonia. The primary aim of this article is to provide a comprehensive review of the various forms of dystonia observed in patients with Parkinson’s disease who can benefit from a therapeutic trial of botulinum toxin. Although most of these indications are not supported by randomized controlled clinical trials and, therefore, not approved by the Food and Drug Administration, there are many open-label trials supporting a large body of empirical experience testifying to the benefits of botulinum toxin treatment in these conditions.
The contribution of periaqueductal gray in the regulation of physiological and pathological behaviors
Authors: Zhang Hui , Zhu Zhe , Ma Wei-Xiang , Kong Ling-Xi , Yuan Ping-Chuan , Bu Li-Fang , Han Jun , Huang Zhi-Li , Wang Yi-Qun
Published: April 2024

Periaqueductal gray (PAG), an integration center for neuronal signals, is located in the midbrain and regulates multiple physiological and pathological behaviors, including pain, defensive and aggressive behaviors, anxiety and depression, cardiovascular response, respiration, and sleep-wake behaviors. Due to the different neuroanatomical connections and functional characteristics of the four functional columns of PAG, different subregions of PAG synergistically regulate various instinctual behaviors. In the current review, we summarized the role and possible neurobiological mechanism of different subregions of PAG in the regulation of pain, defensive and aggressive behaviors, anxiety, and depression from the perspective of the up-down neuronal circuits of PAG. Furthermore, we proposed the potential clinical applications of PAG. Knowledge of these aspects will give us a better understanding of the key role of PAG in physiological and pathological behaviors and provide directions for future clinical treatments.
Elevated gut microbiota metabolite bile acids confer protective effects on clinical prognosis in ischemic stroke patients
Authors: Wang Zhaobin , Li Jing , Xu Yingxin , Liu Ye , Zhang Zhe , Xu Qin , Lin Jinxi , Jiang Yong , Wang Yongjun , Jing Jing , Wang Anxin , Meng Xia
Published: April 2024

Background

There is evidence of an association between the gut microbiota and progression of stroke. However, the relationship between gut microbial metabolites, specifically bile acids (BAs), and post-ischemic stroke disability and poor functional outcomes remains unexplored.

Methods

Patients with acute ischemic stroke (AIS) or transient ischemic attack (TIA) in the Third China National Stroke Registry were grouped according to total bile acid (TBA) quartile on admission. Association of TBA with disability and poor functional outcomes were evaluated using logistic regression models and restricted cubic splines.

Results

Data for 9,536 patients were included. After adjusting for confounders, the risks of disability and poor functional outcomes were significantly lower in the highest TBA quartile than in the lowest TBA quartile at the 3-month follow-up, with respective odds ratios (ORs) of 0.65 (95% confidence interval [CI] 0.55–0.78; p < 0.001) and 0.66 (95% CI 0.55–0.78, p < 0.001). Each standard deviation increase in the TBA level reduced the risks of disability and poor functioning outcomes by 10% (adjusted ORs 0.9 [95% CI 0.83–0.98; p = 0.01] and 0.9 [95% CI 0.83–0.97; p < 0.001], respectively). This association remained similar at the 1-year follow-up. After stratification by TOAST subtype, the risk of disability or a poor functional outcome in patients with the large-artery atherosclerosis or “other” subtype was significantly lower in the highest quartile than in the lowest quartile (p < 0.05).

Conclusion

Serum TBA is an independent risk factor for disability and poor functional outcomes after AIS or TIA, and exerts a protective effects on brain.
Factors associated with stunting in under-five children with environmental enteropathy in slum areas of Jimma town, Ethiopia
Authors: Regassa Rediet , Belachew Tefera , Duguma Markos , Tamiru Dessalegn
Published: April 2024

Introduction

Stunting is a major public health issue with a significant influence on the health and development of children in low-income countries, where it affects up to 32% of children. Nutritional intake is impacted by alterations in intestinal permeability and underlying chronic inflammation, which hinder children’s normal linear growth. Environmental enteropathy is a poorly understood condition with chronic intestinal inflammation. The purpose of this study was to identify the magnitude of stunting, change in growth, and factors associated with stunting and change in height for the age Z-score of children with an elevated lactulose-to-mannitol ratio.

Methods

An observational follow-up study was conducted to follow children with an elevated lactulose-to-mannitol ratio for changes in their linear growth. A lactulose–mannitol test was performed to identify children with elevated lactulose-to-mannitol ratios, indicative of environmental enteropathy. After a 1-year follow-up, anthropometry was repeated to assess their linear growth. A multivariable logistic regression analysis was performed to identify the independent predictors for stunting in children with elevated lactulose-to-mannitol ratios. All tests were two-sided, and a p-value of <0.05 was considered significant.

Results

The prevalence of stunting in children with an elevated L:M at baseline and end line was found to be 72.4% (95% CI: 60.3, 84.5) and 78.4% (95% CI: 66.7, 90.2), respectively. In a multivariate analysis, a low dietary diversity score (<4 food groups), presence of flies and insects in the toilet area, poor handwashing practices during a critical time, and MUAC z < −2 were significantly associated with stunting. Flies and insects in the toilet area and unsafe disposal of feces were significantly associated with changes in HAZ in children with elevated lactulose-to-mannitol ratios, an indicator of environmental enteropathy.

Conclusion

Most of the children with an elevated lactulose-to-mannitol ratio in the study population were stunted, and no significant change in their linear growth was observed after 1-year follow-up. Therefore, further investigation and urgent intervention are needed to prevent environmental enteropathy and stunting among under-five children in this community who are exposed to very poor sanitary conditions and other risk factors for malnutrition.
Adapting food environment frameworks to recognize a wild-cultivated continuum
Authors: Zeitler Lilly , Downs Shauna , Powell Bronwen
Published: April 2024

Food environments, or interfaces between consumers and their food systems, are a useful lens for assessing global dietary change. Growing inclusivity of nature-dependent societies in lower-and middle-income countries is driving recent developments in food environment frameworks. Downs et al. (2020) propose a food environment typology that includes: wild, cultivated, informal and formal market environments, where wild and cultivated are “natural food environments.” Drawing from transdisciplinary perspectives, this paper argues that wild and cultivated food environments are not dichotomous, but rather exist across diverse landscapes under varying levels of human management and alteration. The adapted typology is applied to a case study of Indigenous Pgaz K’Nyau food environments in San Din Daeng village, Thailand, using the Gallup Poll’s Thailand-adapted Diet Quality Questionnaire with additional food source questions. Wild-cultivated food environments, as classified by local participants, were the source of more food items than any other type of food environment (37% of reported food items). The case of Indigenous Pgaz K’Nyau food environments demonstrates the importance of understanding natural food environments along a continuum from wild to cultivated.
Clinical efficacy and safety of combined anti-BCMA and anti-CD19 CAR-T cell therapy for relapsed/refractory multiple myeloma: a systematic review and meta-analysis
Authors: Xu Han , Guan Chaoyang , Xu Peipei , Zhou Dongming , Xu Yong , Chen Bing , Bai Hua
Published: April 2024

Background

The low rates of durable response against relapsed/refractory multiple myeloma (RRMM) in recent studies prompt that chimeric antigen receptor (CAR)-T cell therapies are yet to be optimized. The combined anti-BCMA and anti-CD19 CAR-T cell therapy showed high clinical efficacy in several clinical trials for RRMM. We here conducted a meta-analysis to confirm its efficacy and safety.

Methods

We collected data from Embase, Web of Science, PubMed, CNKI, Wanfang and Cochrane databases up to April 2023. We extracted and evaluated data related to the efficacy and safety of combined anti-BCMA and anti-CD19 CAR-T cell therapies in RRMM patients. The data was then analyzed using RevMan5.4 and StataSE-64 software. PROSPERO number was CRD42023455002.

Results

Our meta-analysis included 12 relevant clinical trials involving 347 RRMM patients who were treated with combined anti-BCMA and anti-CD19 CAR-T cell therapies. For efficacy assessment, the pooled overall response rate (ORR) was 94% (95% CI: 91%-98%), the complete response rate (CRR) was 50% (95% CI: 29%-71%), and the minimal residual disease (MRD) negativity rate within responders was 73% (95% CI: 66%-80%). In terms of safety, the pooled all-grade cytokine release syndrome (CRS) rate was 98% (95% CI: 97%-100%), grade≥3 CRS rate was 9% (95% CI: 4%-14%), and the incidence of neurotoxicity was 8% (95% CI: 4%-11%). Of hematologic toxicity, neutropenia was 82% (95% CI: 75%-89%), anemia was 71% (95% CI: 53%-90%), thrombocytopenia was 67% (95% CI: 40%-93%) and infection was 42% (95% CI: 9%-76%). The median progression-free survival (PFS) was 12.97 months (95% CI: 6.02-19.91), and the median overall survival (OS) was 26.63 months (95% CI: 8.14-45.11).

Conclusions

As a novel immunotherapy strategy with great potential, the combined anti-BCMA and anti-CD19 CAR-T cell therapy showed high efficacy in RRMM, but its safety needs further improvement. This meta-analysis suggests possible optimization of combined CAR-T therapy.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42023455002.
Sunitinib for adenocarcinoma of the rete testis: a case report
Authors: Li Kezhen , Chen Di , He Mingdong , Yu Jun , Mi Hua
Published: April 2024

Background

Adenocarcinoma of the rete testis (AORT) is an extremely rare and aggressive tumor with a poor prognosis. Its etiology and pathological characteristics have not been extensively studied, making accurate diagnosis and appropriate management challenging. AORT, an invasive testicular tumor with a mortality rate of 46%, treatment typically involves radical orchiectomy, retroperitoneal pelvic lymph node dissection (RPLND), adjuvant chemotherapy, and/or ongoing monitoring, but the response to conventional radiation and chemotherapy is limited. At present, no effective targeted therapy for AORT has been found.

Case description

In this case report, we present the clinical scenario of a 50-year-old male patient initially diagnosed with a right testicular hydrocele, who subsequently underwent eversion of the parietal tunica vaginalis. Postoperative pathological analysis revealed metastatic clear cell renal cell carcinoma (ccRCC). PET/CT demonstrated findings suggestive of left renal upper pole carcinoma with involvement of the right scrotum, para-aortic region, bilateral iliac vessels, bilateral inguinal region, and multiple metastases. Sunitinib, a tyrosine kinase inhibitor, is commonly employed in the treatment of ccRCC. The patient underwent treatment with sunitinib for a duration of 20 months, resulting in the inactivation of multiple metastases. Following this, a radical orchiectomy was performed, and the postoperative pathology confirmed the presence of AORT. This article provides a comprehensive account of the patient's medical history, diagnostic process, treatment modalities, and subsequent follow-up observations.

Conclusions

This case report highlights the successful use of targeted therapy with sunitinib in a patient with AORT. The patient showed a positive response to targeted therapy. This study not only provides a novel foundation for the treatment of AORT, but also offers valuable insights for future treatment strategies in managing this particular form of testicular cancer.
Case report: Salivary duct carcinoma in a patient with a germline CDH1 pathogenic variant - expanding the spectrum of hereditary cancer predisposition syndromes
Authors: Desai Nidhi , Racila Emilian , Fujioka Naomi , Gupta Arjun , Antonarakis Emmanuel S.
Published: April 2024

Introduction

Recently, an entity known as salivary duct carcinoma with rhabdoid features (SDC-RF) has been associated with somatic CDH1 mutations. Here we present the first known case report of conventional SDC occurring in the setting of a germline CDH1 pathogenic variant accompanied by a somatic loss of heterozygosity at the CDH1 locus.

Case discussion

A 67-year-old man presented with chest and back pain and was found to have osteolytic lesions in the sternum and lumbar spine. Vertebral bone biopsies were positive for metastatic carcinoma of unknown primary. A molecular profiling assay consisting of both whole-exome next-generation sequencing (NGS) as well as immunohistochemistry (IHC) for select clinically-relevant proteins performed on the bone biopsy suggested a triple-negative (ER/PR/ERBB2 negative, by IHC), androgen receptor (AR IHC) positive tumor profile. Additionally, the assay uncovered a coding mutation in the CDH1 gene (c.1792C>T, p.R598*) with genomic loss of the second CDH1 allele. Germline testing returned positive for a heterozygous CDH1 pathogenic variant. PET-CT revealed a tumor in the neck suggestive of the primary malignancy consistent with that of salivary gland origin. The patient was initially treated with carboplatin and paclitaxel, then pembrolizumab, and finally with AR-directed therapy using leuprolide and enzalutamide. These treatments were not successful, and the patient eventually succumbed to his disease.

Conclusion

Molecular testing revealed that our patient had bi-allelic inactivation of the CDH1 gene. We believe our patient developed a somatic mutation in addition to his preexisting germline CDH1 mutation that ultimately predisposed him to SDC. While previous studies have found somatic CDH1 pathogenic variants in SDC-RF, our patient was found to have a germline CDH1 pathogenic variant in the setting of conventional SDC, without rhabdoid features. This case provokes questions regarding tumor genetics and molecular profiling of SDC in patients with germline CDH1 pathogenic variants. Moreover, this case supports the notion that SDC may be the salivary counterpart of other malignancies associated with germline CDH1 pathogenic variants and may possibly expand the spectrum of tumors that arise in this familial cancer-predisposition syndrome.
Unraveling the functional signals of rods and cones in the human retina: separation and analysis
Authors: Pfäffle Clara , Puyo Léo , Spahr Hendrik , Hillmann Dierck , Miura Yoko , Hüttmann Gereon
Published: April 2024

In recent years, optoretinography has become an important functional imaging method for the retina, as light-evoked changes in the photoreceptors have been demonstrated for a large number of different OCT systems. Full-field swept-source optical coherence tomography (FF-SS-OCT) is particularly phase-stable, and it is currently the only technique sensitive enough to detect the smaller functional changes in the inner plexiform layer (IPL). However, the resolution of state-of-the art FF-SS-OCT systems is not high enough to distinguish individual photoreceptors. This makes it difficult to separate rods from cones. In this work, we circumvent this problem by separating the functional changes in rods and cones by their different temporal dynamics to the same light stimulus. For this purpose, a mathematical model was developed that represents the measured signals as a superposition of two impulse responses. The developed model describes the measured data under different imaging conditions very well and is able to analyze the sensitivity and temporal dynamics of the two photoreceptor types separately.
Case Report: Rapid and progressive left ventricular endocardial calcification in an infant with Williams syndrome
Authors: Zhou Jie , Liu Dan , Chen Jiao
Published: April 2024

Williams syndrome (WS) is characterized by a range of clinical features, including cardiovascular disease, distinctive facial traits, neurobehavioral disorders, and a condition known as transient infantile hypercalcemia. Among these, endocardial calcification represents a non-specific response to severe, etiologically diverse myocardial injuries. In this report, we document a unique case involving an infant with WS who exhibited rapidly progressive arterial stenosis and left ventricular endocardial calcification, associated with a novel heterozygous deletion. While arterial stenosis is the most frequently observed cardiovascular issue in WS, instances of endocardial calcification during infancy are exceedingly rare and have not previously been reported in the context of WS.
Hovenia dulcis: a Chinese medicine that plays an essential role in alcohol-associated liver disease
Authors: He Yi-Xiang , Liu Meng-Nan , Wang Yang-Yang , Wu Hao , Wei Mei , Xue Jin-Yi , Zou Yuan , Zhou Xin , Chen Hui , Li Zhi
Published: April 2024

Globally, alcohol-associated liver disease (ALD) has become an increased burden for society. Disulfirams, Benzodiazepines (BZDs), and corticosteroids are commonly used to treat ALD. However, the occurrence of side effects such as hepatotoxicity and dependence, impedes the achievement of desirable and optimal therapeutic efficacy. Therefore, there is an urgent need for more effective and safer treatments. Hovenia dulcis is an herbal medicine promoting alcohol removal clearance, lipid-lowering, anti-inflammatory, and hepatoprotective properties. Hovenia dulcis has a variety of chemical components such as dihydromyricetin, quercetin and beta-sitosterol, which can affect ALD through multiple pathways, including ethanol metabolism, immune response, hepatic fibrosis, oxidative stress, autophagy, lipid metabolism, and intestinal barrier, suggesting its promising role in the treatment of ALD. Thus, this work aims to comprehensively review the chemical composition of Hovenia dulcis and the molecular mechanisms involved in the process of ALD treatment.
Statins use amidst the pandemic: prescribing, dispensing, adherence, persistence, and correlation with COVID-19 statistics in nationwide real-world data from Poland
Authors: Kardas Przemysław , Kwiatek Angelika , Włodarczyk Piotr , Urbański Filip , Ciabiada-Bryła Beata
Published: April 2024

Background

Adherence to medications presents a significant challenge in healthcare. Statins, used in primary and secondary prevention of cardiovascular disease, are of particular importance for public health. The outbreak of the COVID-19 pandemic resulted in additional healthcare system-related barriers impeding the execution of therapies. This study aimed to assess the use of as well as adherence and persistence to statins in a national cohort of 38 million of Polish citizens during pandemic.

Methods

A retrospective analysis of prescription and dispensation data for all statins users from the national payer organization covering the years 2020–2022 was conducted. Medication adherence was assessed using the Medication Possession Ratio, for persistence the 30-day cut-off was accepted. National data on COVID-19 cases and COVID-19 related deaths were obtained from ECDC.

Results

The analysis identified 7,189,716 Polish citizens (approximately 19% of Polish population) who were dispensed at least 1 pack of statins within the study period. Over that time, there was a continuous significant increasing trend in prescribing and dispensing of statins. Despite a total increase of 18.9% in the number of prescribed tablets, the percentage of tablets dispensed remained similar, averaging 86%. Overall percentage of adherent patients was 48.2%. For a random sample of 100,000 patients, the mean period of continuous therapy in 2022 was 6.2+/- 5.3 months. During the lockdown period, the mean number of prescribed and dispensed tablets was lower by 6.8% and 5.9%, respectively (p < 0.05). However, fluctuations in the number of COVID-19 cases or COVID-19-related deaths per week had no major impact on the prescribing and dispensing of statins.

Conclusion

Over the time of pandemic, there was a continuous increase in the number of statin tablets prescribed and dispensed in Poland. This suggests that, despite the potential limitations posed by COVID-19, access to statins remained easy, which may be attributed to the mass-scale implementation of the national e-prescription system. However, it is crucial to realise that approximately 1/7 of prescribed statin doses were never dispensed, and the overall levels of adherence and persistence were low. This underscores the necessity for concerted efforts to change this scenario in Poland.
Feasibility of the application of frequency modulated continuous wave radar trigger technique in abdominal magnetic resonance imaging
Authors: Song Qingling , He Yongquan , Chen Lihua , Xia Xinyuan , Wang Nan , Song Qingwei , Liu Ailian
Published: April 2024

Objective: To evaluate and compare the image quality of T2-weighted abdominal scans using a respiratory belt trigger (RBT) and frequency-modulated continuous wave (FMCW)-trigger (FT) techniques and to explore the feasibility of FT in abdominal magnetic resonance imaging (MRI).

Methods: The study prospectively included 28 subjects, each undergoing abdominal scans with both RBT and FT. The analysis focused on 64 inconsistent trigger segments from the respiratory curves triggered by RBT and FMCW. Parameters such as inconsistent trigger type (ITT), number of inconsistent trigger points (ITPs), ratio of ITP (ITR), and single-segment ITR (SITR) were derived from these curves. Image quality was evaluated by two observers using subjective scoring, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR). The assessments classified image quality as either “good” or “poor.” Consistency in image quality assessment between observers was determined using the kappa test and intraclass correlation coefficient (ICC). The chi-square test, Student’s t-test, and the Mann–Whitney U test were employed to compare the categorical and continuous variables between the RBT and FT groups.

Results: The observers showed a high level of agreement in image quality assessment. There were no significant differences in ITR, SITR, acquisition time, SNR, and CNR between the RBT and FT groups (all p > 0.05). Both subjective and objective evaluations indicated no notable difference in image quality between the two groups (p > 0.05).

Conclusion: The FMCW trigger technique is a viable alternative to the traditional respiratory belt trigger in scenarios of relatively stable breathing. It offers potential benefits, such as reducing operational demands on technicians and improving MRI workflow efficiency.
UGLS: an uncertainty guided deep learning strategy for accurate image segmentation
Authors: Yang Xiaoguo , Zheng Yanyan , Mei Chenyang , Jiang Gaoqiang , Tian Bihan , Wang Lei
Published: April 2024

Accurate image segmentation plays a crucial role in computer vision and medical image analysis. In this study, we developed a novel uncertainty guided deep learning strategy (UGLS) to enhance the performance of an existing neural network (i.e., U-Net) in segmenting multiple objects of interest from images with varying modalities. In the developed UGLS, a boundary uncertainty map was introduced for each object based on its coarse segmentation (obtained by the U-Net) and then combined with input images for the fine segmentation of the objects. We validated the developed method by segmenting optic cup (OC) regions from color fundus images and left and right lung regions from Xray images. Experiments on public fundus and Xray image datasets showed that the developed method achieved a average Dice Score (DS) of 0.8791 and a sensitivity (SEN) of 0.8858 for the OC segmentation, and 0.9605, 0.9607, 0.9621, and 0.9668 for the left and right lung segmentation, respectively. Our method significantly improved the segmentation performance of the U-Net, making it comparable or superior to five sophisticated networks (i.e., AU-Net, BiO-Net, AS-Net, Swin-Unet, and TransUNet).
Effects of musical expertise on line section and line extension
Authors: Pei Yilai , Xu Zhiyuan , He Yibo , Liu Xinxin , Bai Yuxuan , Kwok Sze Chai , Li Xiaonuo , Wang Zhaoxin
Published: April 2024

Background

This study investigated whether music training led to better length estimation and/or rightward bias by comparing the performance of musicians (pianists) and non-musicians on performance of line sections and line extensions.

Methods

One hundred and sixteen participants, among them 62 musicians and 54 non-musicians, participated in the present study, completed line section and line extension task under three conditions: 1/2, 1/3 and 2/3.

Results

The mixed repeated measures ANOVA analysis revealed a significant group × condition interaction, that the musicians were more accurate than non-musicians in all the line section tasks and showed no obvious pseudoneglect, while their overall performance on the line extension tasks was comparable to the non-musicians, and only performed more accurately in the 1/2 line extension condition.

Conclusion

These findings indicated that there was a dissociation between the effects of music training on line section and line extension. This dissociation does not support the view that music training has a general beneficial effect on line estimation, and provides insight into a potentially important limit on the effects of music training on spatial cognition.
Exploring the potential of ChatGPT for foreign language education at the university level
Authors: Klimova Blanka , Pikhart Marcel , Al-Obaydi Liqaa Habeb
Published: April 2024

Introduction

The purpose of this study is to explore students’ attitudes and perceived usefulness of using ChatGPT for learning a foreign language to reveal how this new trend tool affects its end-users.

Methods

The authors conducted qualitative research by using a questionnaire survey based on hands-on experience by university students.

Results

The findings reveal that students are fascinated, satisfied, and stimulated to use this technology despite some of their reservations and potential threats. The authors of this study also list pedagogical implications, including specific activities, while using ChatGPT.

Discussion

Although ChatGPT can be very beneficial for teachers and help them in their preparation, it sets a challenging task for them to change the existing teaching approaches and assessments to boost students’ cognitive, creative, and critical thinking skills. In addition, both teachers and students will have to upskill their competencies to handle the current advancements in AI technology, such as ChatGPT.
Leading matters! Linking compassion and mindfulness in organizations through servant leadership
Authors: Miralles Sandra , Pessi Anne B. , Pozo-Hidalgo Manuela , Rodríguez-Sánchez Alma
Published: April 2024

Regardless of where they are, humans are inherently human. In this study, we explore the relationship between compassion, mindfulness, and servant leadership contributing to an overall feeling of safety. Adopting a humanistic approach to human resource management, we examine how compassion and mindfulness intersect under the lens of the Conservation of Resources (COR) theory. Our investigation focuses on understanding how servant leadership facilitates the cultivation of mindfulness through compassion. Using structural equation modeling (SEM), we analyze data gathered from 360 workers across diverse occupational sectors. Our findings provide empirical support for the hypothesis that compassion, manifested as a response to suffering, enhances mindfulness levels in the workplace. Specifically, we observe that organizations promoting servant leadership principles are conducive to higher levels of mindfulness among employees. Practically, our study underscores the importance of designing work contexts that prioritize compassion and servant leadership. By doing so, organizations can foster a positive work environment that promotes mindfulness and enhances workplace safety. Our research contributes to the management literature by offering empirical evidence on the role of servant leadership in cultivating compassion and mindfulness, thereby advancing the discourse on workplace safety and organizational well-being.
“We thought we were stronger than we were”: adopters’ narratives about the adoption journey and disruption
Authors: Bejenaru Anca , Raiu Sergiu , Iovu Mihai , Negoescu Alina , Corman Sorina
Published: April 2024

Introduction

Although the majority of adoptive families remain stable, some of them break up prematurely.

Methods

Adopting a qualitative approach, this study gave voice to seven adoption applicants who began the adoption journey with one or more children but did not complete the legal process. Our goal was to understand their experiences throughout the adoption process and disruption.

Results

The results show how adoption applicants went, in a short period, from the excitement of finding a child or sibling group to disillusionment and trauma. The main risk factors that hinder adoption stability include unrealistic expectations, intuitive choice of the child in the absence of accurate information, challenges posed by the child’s particular characteristics, and lack of professional support.

Discussion

Our study highlights the need for adopters to be assisted throughout the entire process by specialists, to be better prepared to deal with the complex needs of children in the protection system, and to facilitate their access to a complex of specialized services to meet the different needs of every family.
Mediating effects of attitude on the relationship between knowledge and willingness to organ donation among nursing students
Authors: Chen Xiaohang , Zhou Xin , Xu Yan , Pan Li , Li Peizheng , Liang Wenjin , Jin Lv , Zhang Chunhua , He Chongxiang
Published: April 2024

Background

The current rate of organ donation in China falls significantly below the global average and the actual demand. Nursing students play a crucial role in supporting and promoting social and public welfare activities. This study primary aims to analyze the levels of knowledge, attitudes, willingness toward organ donation, and attitudes toward death among nursing students, and investigate the mediating role of attitude in the relationship between knowledge and willingness. The secondary aims to identify factors that may influence the willingness.

Methods

A convenience sample of nursing students completed online-administered questionnaires measuring the level of knowledge, attitudes, and willingness toward organ donation before and after clinical internship. Spearman correlation and mediation analyses were used for data analyses.

Results

Before the clinical internship, there were 435 nursing students who had not yet obtained their degrees and were completing their clinical internships. After the internship, this number decreased to 323. The mean score for knowledge before and after the clinical internship (7.17 before and 7.22 after, with no significant difference), the attitude (4.58 before and 4.36 after, with significant difference), the willingness (12.41% before and 8.67% after, with significant difference), the Death Attitude Profile-Revised (DAP-R) score (94.41 before and 92.56 after, with significant difference). The knowledge indirectly affected nursing students’ willingness to organ donation through attitude. Knowledge had a direct and positive impact on attitudes (β = 1.564). Additionally, nursing students’ attitudes positively affected their willingness (β = 0.023). Attitudes played a mediating role in the relationship between knowledge and willingness (β = 0.035). Additionally, attitude toward death, fear of death, and acceptance of the concept of escape were found to be correlated with their willingness.

Conclusion

Organ donation willingness was found to be low among nursing students. Positive attitudes were identified as a mediating factor between knowledge and willingness. Additionally, DAP-R was a related factor. Therefore, it is recommended to focus on improving knowledge and attitude, as well as providing death education to help nursing students establish a positive attitude toward death. These efforts can contribute to the promotion of organ donation.
Ageing as a two-phase process: theoretical framework
Authors: Zane Flaminia , MacMurray Claire , Guillermain Clémence , Cansell Céline , Todd Nicolas , Rera Michael
Published: April 2024

Human ageing, along with the ageing of conventional model organisms, is depicted as a continuous and progressive decline of biological capabilities accompanied by an exponentially increasing mortality risk. However, not all organisms experience ageing identically and our understanding of the phenomenon is coloured by human-centric views. Ageing is multifaceted and influences a diverse range of species in varying ways. Some undergo swift declines post-reproduction, while others exhibit insubstantial changes throughout their existence. This vast array renders defining universally applicable “ageing attributes” a daunting task. It is nonetheless essential to recognize that not all ageing features are organism-specific. These common attributes have paved the way for identifying “hallmarks of ageing,” processes that are intertwined with age, amplified during accelerated ageing, and manipulations of which can potentially modulate or even reverse the ageing process. Yet, a glaring observation is that individuals within a single population age at varying rates. To address this, demographers have coined the term ‘frailty’. Concurrently, scientific advancements have ushered in the era of molecular clocks. These innovations enable a distinction between an individual’s chronological age (time since birth) and biological age (physiological status and mortality risk). In 2011, the “Smurf” phenotype was unveiled in Drosophila, delineating an age-linked escalation in intestinal permeability that presages imminent mortality. It not only acts as a predictor of natural death but identifies individuals exhibiting traits normally described as age-related. Subsequent studies have revealed the phenotype in organisms like nematodes, zebrafish, and mice, invariably acting as a death predictor. Collectively, these findings have steered our conception of ageing towards a framework where ageing is not linear and continuous but marked by two distinct, necessary phases, discernible in vivo, courtesy of the Smurf phenotype. This framework includes a mathematical enunciation of longevity trends based on three experimentally measurable parameters. It facilitates a fresh perspective on the evolution of ageing as a function. In this article, we aim to delineate and explore the foundational principles of this innovative framework, emphasising its potential to reshape our understanding of ageing, challenge its conventional definitions, and recalibrate our comprehension of its evolutionary trajectory.
The effect of Sleep Leadership Training on U.S. Army human performance team members
Authors: Barrow Talia , Yu Bryan , Cooper Carly , DaLomba Elaina , Gregg Brian , Barefield Maria , Umlauf Jon
Published: April 2024

Most U.S. Servicemembers (SMs) get less than the recommended amount of sleep per night, which has been shown to be directly influenced by local leadership. Previous research demonstrated that a brief sleep leadership training (SLT) protocol resulted in improved knowledge and attitudes regarding sleep among U.S. Army leaders, and improvements in the sleep health of their SMs. Human Performance Teams (HPT) offer one solution to propel the cultural change related to sleep, however, little is known about HPT members' own sleep related knowledge, practices, attitudes, and beliefs. This mixed-methods study determined the effect of (SLT) on the sleep-related knowledge, practices, attitudes, beliefs, and perceived competency of HPT members, explored their experiences addressing SM sleep, and gauged their perceived value in receiving the training. Thirty-one individuals received 2 days of SLT. Baseline and 6-week post training follow-up measures were collected, and participants were invited to participate in semi-structured interviews to explore their unique experiences addressing sleep, as well as their perceived value in receiving SLT. Training had no significant effects on HPT members' sleep practices or sleep beliefs, some significant effects on their attitudes and knowledge about sleep, and significant effects on their perceived competence to address sleep in their units. Results suggest that HPT members benefited from the training through enhancement of their competence to address sleep with leadership. However, they struggle to obtain sufficient sleep themselves. More research is needed to identify methods of overcoming specific barriers to sleep imposed on SMs.
Inter-limb differences in upper quarter mobility/stability are not associated with performance in competitive swimmers
Authors: Borgmann Katharina , Panzer Stefan , Limpach Sam , Muehlbauer Thomas
Published: April 2024

Background

The Y Balance Test–Upper Quarter (YBT–UQ) is a cost-effective, well-established, closed kinetic chain test to assess inter-limb asymmetries in the upper quarter that could negatively affect swimming performance. Thus, the aim of the present study was to determine YBT–UQ performances and inter-limb differences as well as its association with swimming performance in athletes with diverging levels of expertise.

Methods

Forty female and male competitive swimmers (age range: 10–22 years) with different expertise levels (A-squad: n = 9, B-squad: n = 12, C-squad: n = 19) were tested (reach distances for the YBT–UQ) and swimming performance was calculated using the ratio of individual to world best time.

Results

YBT–UQ performances (i.e., inferolateral reach direction for the dominant arm: p = .027, ηp2 = .12 and the non-dominant arm: p = .031, ηp2 = .17) but not YBT–UQ inter-limb differences significantly differed between groups and were largest in swimmers with the lowest expertise level (i.e., C-squad). Further, YBT–UQ performances (i.e., inferolateral reach direction [r = −.68 to −.70, both p < .05] and composite score [r = −.65 to −.67, both p < .05] for both arms and medial reach direction for the non-dominant arm [r = −.64, p < .05]) but not inter-limb differences were significantly and negatively correlated with swimming performance among B-squad swimmers.

Conclusions

Our results suggest that inter-limb differences in upper quarter mobility/stability are not influenced by the level of expertise and have no significant associations with swimming performance. However, greater reach distances were correlated with lower swimming performance for the B-squad swimmers indicating that a training-related increase in upper quarter mobility/stability could worsen swimming performance in those athletes.
Molecular Characterization and Expression Analysis of the C-Type Lectin Domain Family 4 Member F in Litopenaeus vannamei against White Spot Syndrome Virus
Authors: Xue Qian , Yang Bingbing , Luo Kun , Luan Sheng , Kong Jie , Li Xupeng , Meng Xianhong
Published: April 2024

White spot disease (WSD) outbreaks pose a significant threat to the Pacific white shrimp (Litopenaeus vannamei) farming industry. The causative agent is the white spot syndrome virus (WSSV). There are no effective treatments for WSD so far. Therefore, understanding the resistance mechanisms of L. vannamei against the WSSV is crucial. C-type lectins (CTLs) are important pattern recognition receptors (PRRs) that promote agglutination, phagocytosis, encapsulation, bacteriostasis, and antiviral infections. This study cloned the C-type lectin domain family 4 member F (LvCLEC4F) from L. vannamei. LvCLEC4F contains a 492 bp open reading frame (ORF) encoding a protein of 163 amino acids, including a carbohydrate recognition domain (CRD). Following a challenge with the WSSV, the expression profile of LvCLEC4F was significantly altered. Using RNA interference (RNAi) technology, it was found that LvCLEC4F promotes WSSV replication and affects the expression levels of genes related to the regulation of apoptosis, signaling and cellular stress response, and immune defense. Meanwhile, the hemolymph agglutination phenomenon in vivo was weakened when LvCLEC4F was knocked down. These results indicated that LvCLEC4F may play an important role in the interaction between L. vannamei and WSSV.
Numerical Simulation of Double-Row Retaining System with Different Piers
Authors: Sui Yaohua , Zhang Siyuan , Li Zhili , Zhang Xuqun , Wu Fan , Tai Pei
Published: April 2024

With the rapid expansion of foundation pit excavation areas due to the burgeoning underground transportation networks in large cities, spatial combined double-row retaining structures have become indispensable for ensuring stability and minimizing deformation. Integrating piers into these structures enhances stiffness; however, the research on this topic is limited. This study investigates the Chisha Metro project, which utilizes a double-row support structure with added support piers to improve overall stiffness. Numerical simulations are employed to model the foundation pit and analyze the stress distribution and deformation of double-row retaining systems with T-shaped, cross-shaped, or square-shaped piers. The results demonstrate that the retaining system, after the introduction of piers, exhibits reduced maximum horizontal displacement and surface settlement of soil, and indicates spatial characteristics and the transformation from a planar problem to a spatial problem. Furthermore, in specific geological conditions, the T-shaped support pier proves to be more effective in connecting the front and rear support structures compared to the cross-shaped and square-shaped support piers, which mainly reinforce the soil without connecting the support structures. This research provides valuable insights for improving design and construction practices in foundation pit engineering.
Pseudo-Dynamic Tests on Frame–Shear Wall Structure with Precast Concrete Diaphragm
Authors: Han Chun , Dong Xinhong , Su Qunshan , Duan Chunming , Tian Guoping
Published: April 2024

In order to study how to improve the spatial action of precast monolithic composite floor slabs, and examine replacing the cast-in-place surface layer for reducing the weight of structure, we used pseudo-dynamic tests on one-quarter scale models of two-span and three-story frame structures. The lateral load tests compared the stresses and displacements with a cast-in-place floor frame–shear wall structure (SJ1) and a precast monolithic floor frame–shear wall structure with X horizontal braces at the bottom of the floor (SJ2). The results show the X horizontal braces can improve the spatial action. Structural integrity (SJ2) as well as the effective transmission of the horizontal force can be ensured by additional X bracing at the bottom of the rigidity of the floor without a cast-in-place concrete topping. The results show that X horizontal braces more effectively transfer horizontal stress, which provides a beneficial reference for similar research.
Electrolyte Influence on Properties of Ultra-Thin Anodic Memristors on Titanium
Authors: Knapic Dominik , Atanasova Elena , Zrinski Ivana , Hassel Achim Walter , Mardare Andrei Ionut
Published: April 2024

Titanium anodic memristors were prepared in phosphate buffer (PB) and citrate buffer (CB) electrolytes. Studying their I-U sweeps, the memristors presented self-rectifying and volatile behaviors. Transmission electron microscopic analysis revealed crystalline protrusions inside a semi-crystalline Ti oxide. Grounded in this, a hybrid interfacial memristive switching mechanism relaying on partial filaments was proposed. Moreover, both analyzed memristor types demonstrated multilevel switching capabilities. The memristors anodized in the PB and CB showed high-to-low resistance ratios of 4 × 104 and 1.6 × 102, respectively. The observed (more than two order of magnitude) ratio improvement of the PB memristors suggests their better performance, in spite of their modestly high resistive state instabilities, attributed to the thermal stress caused by consecutive switching. The endurance and retention of both the PB and CB memristors was measured over up to 106 cycles, indicating very good lifetimes. Phosphate incorporation into the anodic oxide was confirmed by photoelectron spectroscopy analysis and was related to the improved memristive behavior of the PB sample. The presence of phosphate inside the memristively active layer modifies the availability of free O species (vacancies and ions) in the oxide. Taking all this into consideration, Ti anodic memristors anodized in PB are emphasized as candidates for neuromorphic computing.
Current Concepts in the Treatment of Giant Cell Tumor of Bone: An Update
Authors: Tsukamoto Shinji , Mavrogenis Andreas F. , Masunaga Tomoya , Honoki Kanya , Fujii Hiromasa , Kido Akira , Tanaka Yasuhito , Errani Costantino
Published: April 2024

Curettage is recommended for the treatment of Campanacci stages 1–2 giant cell tumor of bone (GCTB) in the extremities, pelvis, sacrum, and spine, without preoperative denosumab treatment. In the distal femur, bone chips and plate fixation are utilized to reduce damage to the subchondral bone and prevent pathological fracture, respectively. For local recurrence, re-curettage may be utilized when feasible. En bloc resection is an option for very aggressive Campanacci stage 3 GCTB in the extremities, pelvis, sacrum, and spine, combined with 1–3 doses of preoperative denosumab treatment. Denosumab monotherapy once every 3 months is currently the standard strategy for inoperable patients and those with metastatic GCTB. However, in case of tumor growth, a possible malignant transformation should be considered. Zoledronic acid appears to be as effective as denosumab; nevertheless, it is a more cost-effective option. Therefore, zoledronic acid may be an alternative treatment option, particularly in developing countries. Surgery is the mainstay treatment for malignant GCTB.