bluuebunny/crossref_metadata_2025 huggingface dataset:
Transcriptional landscape of intestinal environment in DSS-induced ulcerative colitis mouse model
Authors: Wen Yuefei , Li Chenyang , Huang Peng , Liu Zhigang , Liu Bin , He Yanjun
Published: April 2023

Ulcerative colitis (UC) is a chronic inflammatory disease that affects the colon and is becoming increasingly prevalent worldwide. To identify new diagnostic and therapeutic avenues for UC, we sequenced colons of UC mouse models and analyze their difference in expressed genes (DEGs), pathway, construct protein-protein interaction (PPI) and ceRNA networks. We identified novel DEGs include Tppp3, Saa3, Cemip, Pappa, Nr1d1, and found they enriched in cytokine-mediated signaling, extracellular matrix organization, extracellular structure organization, and external encapsulating structure organization, indicating that UC pathogenesis is significantly affected by the functional and clinically significant interactions between immune and non-immune cells and the extracellular matrix (ECM). Besides, several important nodes were found in Protein-protein interaction (PPI) network, such as Stat3, Il1b, Mmp3, and Lgals3, and found them involved in cytokine-mediated signaling pathway playing a critical role in inflammation. Additionally, ceRNA network analysis revealed the involvement of Smad7 lncRNA. The hub miRNAs in the ceRNA network were mmu-miR-17-5p, mmu-miR-93-5p, mmu-miR-20b-5p, mmu-miR-16-5p, and mmu-miR-106a-5p, while the hub mRNAs were Egln3, Plagl2, Sema7a, Arrdc3, and Stat3. These findings suggest that ceRNA networks play a role in the progression of UC and may aid in elucidating its pathogenesis.
TM4SF19-mediated brake of macrophage efferocytosis contributes to obesity-induced inflammation of adipose tissue
Authors: lee Yun-Hee , Choi Cheoljun , Jeong Yujin , Kim Minji , Choi Garam , Namgoong Sik , Jung Young Suk , Granneman James , Chung Yeonseok , Kim Jong , Choi Yoon Ha
Published: April 2023

Adipose tissue macrophages are critical players in obesity-induced inflammation and metabolic dysfunction. Here, we identify transmembrane 4 L six family member 19 (TM4SF19) as a gene upregulated in adipose tissue macrophages in obese states. We demonstrate that TM4SF19 is a lysosomal membrane protein that inhibits vacuolar H+-ATPase activity by interacting with its subunit ATP6V0B. In vitro gain- and loss-of-function assays in macrophages indicate that TM4SF19 reduces lysosomal acidification and impairs the clearance of dead fat cells. Single-nucleus RNA sequencing analysis indicates that TM4SF19 is specifically expressed in a subpopulation of Trem2 + lipid-associated macrophages, and global knockout reduces diet-induced obesity and recruitment of pro-inflammatory macrophages to adipose tissue. Moreover, global or macrophage-specific TM4SF19 knockout decreases the number of lipid-stressed adipocytes induced by high-fat feeding and restores tissue insulin sensitivity. Overall, these results suggest that TM4SF19-mediated control of lysosomal activity is a potential therapeutic target to resolve obesity-induced adipose tissue inflammation.
Gender-based violence among healthcare students: prevalence, description and associated factors
Authors: Tavolacci Marie-Pierre , Karmaly Alice , Gharbi-hamza Najla , Veber Benoit , Ladner Joel
Published: April 2023

The aims of the current study were to describe five types of gender-based violence (GBV) among healthcare students; and to identify factors associated with GBV. A cross-sectional study was conducted among voluntary healthcare students in France. Five types of GBV were noted: (1) damage to a person’s image due to a sexual connotation on social networks, (2) sexist remarks and behaviour, (3) comments with sexual connotations, (4) sexual assaults and (5) rape or attempted rape. One thousand one hundred and fifty-two students were included. The mean age was 20.8 years (SD = 2.26), 82.6% of students were women (0.4% non-binary). Since the beginning of their studies, 41.2% of students CI 95% [39.7–42.6] were exposed to at least one type of GBV: 15.8% among men CI 95% [13.2–18.4] and 46.0% CI 95% [44.4–47.6] among women (p < 0.001). After multivariate analysis, being a woman, LGBTQ+, a nurse, a physiotherapist student, having a job, living in a roommate and year of study were risk factors for GBV. GBV is so common at colleges and universities and can have such severe consequences for students that more work is needed to generate a culture change and ensure safe learning environments.
Patterns of Postnatal Weight Gain and its predictors among Preterm Very Low Birth Weight Neonates Born in Bahir-Dar Public Hospitals Retrospective Follow up Study, 2022
Authors: Ayehu Yihenew , Hailemeskel Solomon , Mekonen Jalane
Published: April 2023

Introduction: Postnatal weight gain in very low birth weight babies remains a challenge to the management of the neonatal period in low and middle income countries like Ethiopia, where no many feeding alternatives and follow up charts are available. Even though, extra-uterine growth retardation is a common problem in preterm, very low birth weight babies, there is lack of evidence in resource limited countries on patterns of postnatal weight gain. Therefore this study aimed to assess the Patterns of postnatal weight gain and its predictors among Preterm Very Low Birth Weight Infants Born in Bahir-Dar public hospitals neonatal care unit, 2022.Methods A Retrospective follow-up study was conducted among 206 neonates who were admitted to the neonatal intensive care unit of Bahir Dar city public hospitals for the last 2 years. The calculated sample sizes for each hospital were assigned proportionally. The actual data was collected through structured questionnaires and analyzed by using Stata14.0. Outcome variables were compared using log-binomial regression and reported using adjusted risk ratios (aRR) with 95% confidence intervals and P- value < 0.05 was considered statistically significant.Result The average postnatal weight gain among preterm very low birth weight neonates from regaining birth weight to discharge was 11.1g/kg/d and 85.4% CI (79.9-89.66) of neonates had poor postnatal weight gain at discharge. Preterm very low birth weight neonates delivered by SVD (aRR = 1.38, 95% CI :( 1.34–1.40), delivered after 34 weeks of gestation (aRR = 2.95, 95% CI: (1.62–5.39)), birth z-score >-1.29 (aRR = 3.17, 95% CI: (1.91–5.28)), first feed on the first day (aRR = 2.55, 95% CI: (1.19–5.47)), regaining birth weight within 14 days (aRR = 3.62, 95% CI: (1.45–9.03)) and neonates who had no respiratory distress syndrome (aRR = 3.27, 95% CI: (1.09–9.77) had statistical significant association with adequate postnatal weight gain.Conclusion According to the findings of this study postnatal weight gain for preterm very low birth weight neonates was lower than recommended weight gain by neonatal intensive care unit guideline of Ethiopia. Gestational age, mode of delivery, at birth z-score, initiation time of first feeding, time to regain birth weight and respiratory distress syndrome were factors associated with postnatal weight gain.
Endoplasmic reticulum activation of the caspase-12/9/3 cascade via ATG5 leads to sterogenic femoral head necrosis
Authors: Liu Wanlin , Jiang Boyong , Wang Lianjuan , Zhao Zhenqun , Gong Yulin
Published: April 2023

Programmed osteocyte death might be a pathogenesis of steroid-related avascular necrosis of the femoral head (SANFH). Autophagy-related gene 5 (ATG5) can activate the unfolded protein response pathway under endoplasmic reticulum stress (ERS) to participate in cell regulation, but the regulatory mechanism remains unclear. We examined the role of ERS in SANFH pathogenesis by studying the ATG5 participation mechanism in osteoblast apoptosis regulation to provide a theoretical basis for developing new SANFH therapeutic targets. Rat bone marrow mesenchymal stem cells cultured in vitro underwent osteogenic induction and alizarin red staining. The resultant osteoblasts were divided into Control, SANFH (methylprednisolone-treated), SANFH+ATG5 small interfering RNA (siRNA) (methylprednisolone-treated ATG5 siRNA transfection) groups. Beclin 1, MAP1LC3, ATG5, PERK, and caspase-3, -9, and -12 mRNA and protein expression levels were detected, the osteoblast survival rate was measured, and apoptosis was detected. The relationship between Beclin 1, MAP1LC3, ATG5, PERK, and caspase-3, -9, and -12 mRNA and protein expression levels and osteoblast apoptosis was analyzed. The SANFH group had enhanced expression of the autophagy-related genes Beclin 1 and MAP1LC3 and numerous autophagosomes were formed. Osteoblast injury stimulated ERS. ATG5 siRNA inhibited the glucocorticoid-induced osteoblast autophagy and ERS. The ER stimulated the caspase-12/9/3 cascade through ATG5 to enhance apoptosis and improve persistent ERS. The continuous action of methylprednisolone increased Beclin 1 and MAP1LC3 gene expression, resulting in bone cell injury and stimulating ERS. The ER activated the caspase-12/9/3 cascade via ATG5 under persistent and unchangeable ERS, leading to apoptosis and SANFH.
Exploring declared and taught curricula at a UK dental school through the lens of pulp management.
Authors: Brooks Laura , Edwards David , Field James , Ellis Janice
Published: April 2023

Introduction: This paper explores the declared and taught endodontic curriculum within an undergraduate dental programme in the UK, as part of a wider study which also investigates the learned curriculum. Management of the dental pulp was chosen due to the availability of clear internationally recognised guidelines.
Method: The declared curriculum was identified through existing course guides, seminar and practical session plans. The formal taught curriculum was identified by cataloguing all lectures, practical teaching sessions, seminars and handouts available to dental students. Questionnaires using clinical vignettes were used to explore the informal taught curriculum.
Results: Valid responses to the questionnaire were received from 25/40 (62.5%) clinical supervisors. Disparities between national guidelines, the declared and taught curriculum were primarily due to broad learning objectives and disparate information from lectures and supervising clinicians. Although the majority of formal teaching aligned with national guidelines, the main deviation occurred within the informal taught curriculum.
Conclusion: This study highlights disparities between current evidence-based guidelines, the declared and the taught curriculum in relation to pulp management in a UK dental school. Recommendations: all policies, procedures and protocols are updated and aligned to a contemporaneous evidence base annually, and engagement with clinical lecturers to enable more standardised teaching.
A Comparative Study of Classification Techniques and Imbalanced Data Treatment for Prediction of Software Faults
Authors: Bafna Rishabh , Jain Ridham , Malhotra Ruchika
Published: April 2023

Software Defect Prediction is one of the major challenges faced by software engineers across the world as software grows in size and function. It is the process of identifying error-prone modules in software before the testing phase, which helps with cost-cutting and saves time. The primary goal of this research is to compare the different data balancing techniques along with the popular classification models used for software fault prediction and optimize the best results. In this study, we have used the AEEEM dataset, along with mean value treatment and min-max scaling to pre-process data. Then dataset balancing is performed using class-weight-based, over-sampling, under-sampling, and hybridization techniques. The balanced datasets are now analyzed using 5 classification techniques: Random Forest Classifier, XGBoost, Support Vector Classifier, LightGBM, and Logistic Regression. Thus, a total of 25 combinations are accessed to find the best results using 10-fold cross-validation with f1-score and AUC as the performance metric. Further, the best methods are improved using feature selection. Finally, the best case is optimized using Optuna.
Comprehensive Assessment of Postoperative Recurrence and Survival in Patients with Cervical Cancer: Nomograms
Authors: Zhang Yu , Li Linrui , Jia Haodong , Qian Liting , Wu Qibing , Dong Jiangning
Published: April 2023

Background To investigate the value of nomograms based on clinical parameters, inflammatory indicators, intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) and MRI-derived radiomics in predicting recurrence-free survival (RFS), disease-free survival (DFS), cancer-specific survival (CSS) and overall survival (OS) in cervical cancer patients after surgery.Methods A retrospective analysis of 181 cervical cancer patients operated at our hospital between January 2015 and January 2021 with continuous follow-up was completed. The parameters of IVIM-DWI and radiomics were measured, analyzed and screened. The logistic regression with LASSO regularization was used to calculate radiomics score (Rad-score). Multivariate Cox regression analysis was used to construct nomogram models for predicting postoperative RFS, DFS, CSS and OS in cervical cancer patients, with internal and external validation.Results Clinical stage, parametrial infiltration, internal irradiation, D-value and Rad-score were independent prognostic factors for RFS; Squamous cell carcinoma antigen, internal irradiation, D-value, f-value and Rad-score were independent prognostic factors for DFS; Maximum tumor diameter, lymph node metastasis, platelets, D-value and Rad-score were independent prognostic factors for CSS; Lymph node metastasis, systemic inflammation response index, D-value and Rad-score were independent prognostic factors for OS. The AUCs of each model predicting RFS, DFS, CSS and OS at 1, 3 and 5 years were 0.985, 0.929, 0.910 and 0.833, 0.818, 0.816 and 0.832, 0.863, 0.891 and 0.804, 0.812, 0.870, respectively.Conclusions Nomograms based on clinical and imaging parameters showed high clinical value in predicting postoperative RFS, DFS, CSS and OS of cervical cancer patients and can be used as prognostic markers.
Assessing the Qualitative and Quantitative Performance of Hostels and Mess for an HEI through Multi-Criteria Decision Making
Authors: PANWAR ANKITA , Pant Millie
Published: April 2023

Performance measurement of a unit or an organization is a concrete step for maintaining quality services and should be done periodically to assess the strengths and weaknesses of an organization. The assessment of performance depends on several criteria and is basically a multi-criterion decision-making (MCDM) problem for which various techniques are available in the literature. In the present study, the objective is to measure the performance of hostels and mess facilities of a Higher Educational Institute (HEI) through multi-criteria decision-making methods. On the basis of a survey conducted, a total of 13 criteria are identified which affect the performance of the hostel and mess. Two well-known MCDM techniques, data envelopment analysis (DEA) and analytic hierarchy process (AHP), are used for analyzing the results. While DEA is used for the quantitative analysis, AHP is used for the qualitative analysis. Further, the relevant performing factors for hostels and mess are also identified through AHP and sensitivity analysis-DEA (DEA-SA).
Machine learning-enabled early prediction of dimensional accuracy for complex products of investment casting
Authors: dong ruizhe , Wang Wenhu , Wang Yuanbin , Zhang tianren , Jiang Ruisiong , Cui Kang
Published: April 2023

For the foundry industry, predicting the dimensional accuracy of investment precision castings is vital yet challenging. In order to reduce cost loss caused by out-of-tolerance phenomena, this work develops a data-driven framework for estimating and screening early products based on machine learning techniques. The hollow turbine blade is analyzed as a typical case for the proposed framework. Initially, a database was compiled from the same production line of wax patterns and corresponding castings. Feature engineering techniques were employed to choose the most important characteristics and simplify inputs, employing reject rate analysis and decision tree analysis. Random forest regressors (RFRs) were chosen as the fundamental models after a sensible selection of machine learning algorithms. To enhance the performance of RFRs, the results suggested that the thickness distribution of the source material is another crucial element in determining the dimensional correctness of castings. Ultimately, a hybrid metaheuristic strategy incorporating RFR and dung beetle optimization was developed. The results showed that the proposed prediction model could minimize the error by 22.4% compared to conventional models, making it an valuable tool for early dimensional quality evaluation and guiding wall thickness control for hollow turbine blades.
Evaluation of Dimensional Stability of 3D-printed Dental Casts
Authors: Vincze Zsófia Éva , Kovács Zoltán Imre , Názár Vivien , Oskovics László , Vass Fanni , Borbély Judit , Márton Krisztina
Published: April 2023

Background The objective of this research was to investigate the change in dimensional stability of 3D printed dental model construction types with time. By comparing the models to each other, we sought to find the most suitable building technique based on causing the least deformation of the 3D printed model with time.Methods Four dental casts were printed at an angle of 0°, polymerizing every 50 µm using UV light with a wavelength of 405 nm. The four types of models were as follows: 2.5 mm wall thickness hollow (2,5 mm.H), 2 mm wall thickness hollow (2 mm.H), 2 mm wall thickness hollow with stabilization bars (2 mm.B), and 2 mm wall thickness with hollow with gypsum base (2 mm.G). Casts were digitized with a laboratory scanner (3Shape E3 Red E Scanner) after printing, to create the reference Standard Tessellation Language (STL) files. All models were stored under constant conditions (25°C and 50% humidity) and scanned again after 1 day and 1, 2 and 10 weeks. These scan data were compared to the reference STL file and were analysed by comparing the deformation in a surface fitting software (Geomagic Control X, 3D Systems). The results were statistically evaluated using paired Student’s t tests with the SPSS 23.0 software program. The significance level was set at p < 0.05.Results There were significant differences in dimensional stability after 10 weeks between the 2.5 mm.H(18,45 µm ± 7,661) and 2 mm.B(11,49 µm ± 2,648), p < 0.05; the 2 mm.H(13,81 µm ± 3,18) and 2 mm.G(21,57 µm ± 1,897) p < 0.0001; and the 2 mm.B(11,49 µm ± 2,648) and 2 mm.G(21,57 µm ± 1,897) p < 0.0001 casts. The results suggest that the 2 mm.B casts experienced the least deformation.Conclusions For of all casts, the deformation stayed within the clinical acceptance range, but there were significant differences between the different building structures. Of this four structures, the 2 mm cast with a stabilization bar (2 mm.B) showed the best results.
Applying a convolutional neural network as a statistical method to evaluate the correlation between diabetic retinopathy and diabetic nephropathy
Authors: Li Tao , Tang Juan , Gao Jiayou , Su Xingpin , Lv Jing , Zhai Yuanwei , Qi Xing , Dai Chuanqiang , Liu Guogang , Zhou Yan , lin Sheng , Wang Huaguo , Liu Zejiang , Lin Zhiwu , Liao Qingsan , Li Jiaman
Published: April 2023

Objective At present, there is no consensus on the relationship between diabetic nephropathy (DN) and diabetic retinopathy (DR), and there is a lack of imaging data to prove the correlation between them. Therefore, we aimed to investigate the common risk factors for DN and DR in patients with type 2 diabetes and used Emission Computed Tomography(ECT) imaging technology and clinical test criteria to assess the correlation between DR and DN.Purpose The convolutional neural network was employed to observe and detect pathological changes in DR and DN images. And further analyze the correlation between DR and DN through clinical test data.Results In this study, we discovered that with the aggravation of DR, SCR, BUN and ACR gradually increased while GFR decreased. The incidence of DN in the non-DR, mild-NPDR, moderate-NPDR, severe-NPDR and PDR groups was 4.17%, 28.33%, 55%, 75.83% and 91.67%, respectively. Multivariate linear regression analysis showed that duration of T2D, smoking, HbA1c, TC, TG, HDL-c, LDL-c, UAlb, Scr, BUN, UAlb, ACR, GFR, ACR and GFR were independent risk factors for DR. Renal dynamic ECT imaging analysis demonstrated that with the aggravation of DR, renal blood flow perfusion gradually decreased, thus resulting in a decrease in renal filtration function. In T2D patients, DR and DN show a linear aggravation relationship, and hypercholesterolemia and renal dysfunction are common risk factors for DR and DN.Conclusion The convolutional neural network provides a more accurate, efficient and easier way to analyze DR and DN images. Early screening of the renal function index in DR patients using ECT imaging technology will help to identify and prevent DN as early as possible.
Targeting Sex Determination to Suppress Mosquito Populations
Authors: Akbari Omar , Li Ming , Kandul Nikolay , Sun Ruichen , Yang Ting , Benetta Elena Dalla , Brogan Daniel , antoshechkin igor , C Héctor Sánchez , Zhan Yin Peng , DeBeaubien Nicolas , Loh YuMin , Su Matthew , Montell Craig , Marshall John
Published: April 2023

Each year, hundreds of millions of people are infected with arboviruses such as dengue, yellow fever, chikungunya, and Zika, which are all primarily spread by the notorious mosquito Aedes aegypti. Traditional control measures have proven insufficient, necessitating innovations. In response, here we generate a next generation CRISPR-based precision-guided sterile insect technique (pgSIT) for Aedes aegypti that disrupts genes essential for sex determination and fertility, producing predominantly sterile males that can be deployed at any life stage. Using mathematical models and empirical testing, we demonstrate that released pgSIT males can effectively compete with, suppress, and eliminate caged mosquito populations. This versatile species-specific platform has the potential for field deployment to control wild populations, safely curtailing disease transmission.
Surgical aortic valve replacement etiologies, hemodynamics, and outcomes in 1346 patients from the Malaysian Heart Centre
Authors: Roslan Aslannif , Soon Chong Kee , Sin Tey Yee , Aktifanus Ahmad Tantawi Jauhari , Ling Soh Si , Boon Wong Kian , Rusani Beni I. , Hadi Hafidz Abd , Kolanthaivelu Jayakhanthan , Yahaya Shaiful Azmi , Dillon Jeswant , Yunus Alwi M.
Published: April 2023

Background:This study examined the characteristics and outcomes of surgical aortic valve replacement in Malaysia from 2016 to 2021.
Methods: This was a retrospective study of 1346 patients analyzed on the basis of medical records, echocardiograms and surgical reports. The overall sample was both considered as a whole and divided into aortic stenosis (AS)/aortic regurgitation (AR)-predominant and similar-severity subgroups.
Results: The most common diagnosis was severe AS (34.6%),withthe 3 most common etiologies being bicuspid valve degeneration (45.3%), trileaflet valve degeneration (36.3%) and rheumatic valve disease (12.2%). The second most common diagnosis was severe AR (25.5%),with the most common etiologies being root dilatation (21.0%), infective endocarditis (IE) (16.6%) and fused prolapse (12.2%). Rheumatic valve disease was the most common mixed disease. A total of 54.5% had AS-predominant pathology (3most common etiologies: bicuspid valve degeneration valve, degenerative trileaflet valve and rheumatic valve disease), 36.9% had AR-predominant pathology (top etiologies: root dilatation, rheumatic valve disease and IE), and 8.6% had similar severity of AS and AR. Overall, 62.9% of patients had trileaflet valve morphology, 33.3% bicuspid, 0.6% unicuspid and 0.3% quadricuspid. Among cases of severe AS, the majority were high-gradient severe AS (49.9%),followed by normal-flow low-gradient (LG) severe AS (10.0%), paradoxical low-flow (LF)-LG severe AS (6.4%) and classical LF-LG severe AS (6.1%). The overall in-hospital and total 1-year mortality rates were 6.4% and 13.4%, respectively. Pure severe AS had the highest mortality. For AS-predominant pathology, the etiology with the highest mortality was trileaflet valve degeneration; for AR-predominant pathology, it was dissection. The overall survival probability at 5 years was 79.5% in the full sample, 75.7% in the AS-predominant subgroup, 83.3% in the AR-predominant subgroup, and 87.3% in the similar-severity subgroup.
Conclusions: The most common cause of AS is bicuspid valve degeneration,but trileaflet valve degeneration has worse outcomes. Rheumatic valve disease is an important etiology of both AS and AR. Surgical aortic valve replacement has higher mortality in Malaysia than in developed countries.
Trial registration: IJNREC/562/2022
Distinct intrathecal inflammatory signatures following relapse and anti- COVID-19 mRNA vaccination in Multiple Sclerosis. A cross-sectional study.
Authors: Bruno Antonio , Buttari Fabio , Dolcetti Ettore , Azzolini Federica , Borrelli Angela , Lauritano Gianluca , Caprio Veronica , Rizzo Francesca Romana , Gilio Luana , Galifi Giovanni , Furlan Roberto , Finardi Annamaria , Guadalupi Livia , Musella Alessandra , Mandolesi Georgia , Centonze Diego , Bassi Mario Stampanoni
Published: April 2023

Background: The role of off-target inflammatory response to vaccination in exacerbating multiple sclerosis (MS) is a matter of debate.
Methods: In this cross-sectional study, we compared the CSF cytokine profiles associated with MS relapses and anti-COVID-19 mRNA vaccinations in patients with relapsing-remitting MS (RRMS). We also compared central inflammatory responses between RRMS patients and individuals without neuroinflammatory disorders. All patients were recruited in the Neuromed Research Institute, Pozzilli (IS).
Results: We enrolled 97 consecutives unvaccinated RRMS patients with a clinical relapse occurring within 100 days from the diagnostic lumbar puncture (LP), 29 consecutive RRMS in clinical remission, and 24 consecutive controls. The latter groups of patients received anti-COVID-19 mRNA vaccine within 100 days from LP. In the first group, we observed a significant negative correlation between relapse distance and CSF concentrations of IL-2 (Spearman’s rho= -0.305, p = 0.002), IL-6 (Spearman’s rho= -0.291, p= 0.004), and IL-17 (Spearman’s rho= -0.275, p = 0.006). Linear regression confirmed a significant association for IL-2 (beta = -0.265, 95% CI -0.004 - 0, p = 0.016), IL-6 (beta = -0.284, 95% CI -0.005 - -0.001, p = 0.01), and IL-17 (beta = -0.224, 95% CI -0.004 - 0, p = 0.044), considering possible confounders (age, sex, OCB presence, EDSS).
In the second group, distance from vaccination was positively correlated with CSF levels of IL-12 (Spearman’s rho = 0.539, p= 0.003), IL-13 (Spearman’s rho = 0.512, p = 0.005), IL-1ra (Spearman’s rho = 0.481, p = 0.008), MIP-1a (Spearman’s rho = -0.371, p = 0.047). Linear regression confirmed a significant association for IL-12 (beta = 0.536, 95%CI 0.004-0.016, p = 0.004), IL-13 (beta = 0.416, 95%CI 0.001-0.02, p = 0.035), and IL-1ra (beta = 0.506, 95%CI 0.259-2.344, p = 0.016), also considering the effect of other possible confounders (age, sex).
No significant associations between vaccine distance and CSF cytokines levels emerged in the control group.
Conclusion: Our results indicate that COVID-19 vaccination causes in RRMS patients a central inflammatory response significantly different from that associated with disease relapses. The lack of central inflammatory response observed in control patients indicates that MS patients are suscptible to the central inflammatory effects of vaccination.
Exercise-induced secretion of NT-pro BNP in asymptomatic hypertensive patients with type 2 diabetes mellitus – an early sign of subclinical ventricular dysfunction
Authors: Păun Nicolae , Busnatu Ștefan-Sebastian , Jinga Viorel , Iliesiu Adriana Mihaela , Uscoiu Gabriela , Capitanescu Andrei , Nicolae Camelia
Published: April 2023

Background: The association between hypertension (HTN) and type 2 diabetes mellitus (DM) frequently leads to left ventricular diastolic dysfunction (DD).
Methods: We aim to test whether DD can readily be unveiled as early as in the subclinical stage in diabetic hypertensive asymptomatic patients, even before echocardiography can do so. We compared the values of NT-pro BNP (as a marker of increased filling pressures) before and after the treadmill stress test in hypertensive patients with and without diabetes mellitus (DM) and normal subjects. All had normal systolic and diastolic functions at rest and after the stress test, according to the recommendations of the ESC.
Results: The results from our study showed a significant increase inNT-pro BNP after the stress test, but only in hypertensive patients with diabetes.
Conclusion: Compared with echocardiography, measuring the changes inNT-pro BNP after the stress test in hypertensive and diabetic patients with class A heart failure could be a tool for diagnosing DD much earlier in the evolution of the disease. This is an important finding because these patients are difficult to distinguish from those with normal left ventricle function, based only on restingNT-pro BNP or echocardiography. In this way, they can benefit much earlier from specific therapies to mitigate future cardiovascular events.
DNA binding and Antibacterial study of a new highly planar Cu(II) Network
Authors: Li Xuan , Li Juan , Jiang Miao , Song Xue-Qin , Zhang Pei , Zhao Nana , Cheng Hao
Published: April 2023

The DNA binding and the antibacterial activities of metal organic compounds have great significance for the development of anticancer drugs. In this study, a copper coordination network, [Cu2L(H2O)2]n (CuNet), based on H4L where 2,6-pyridine-dicarboxylic acid moieties are spaced by p-benzyloxy, is prepared hydrothermally. Single crystal X-ray analysis demonstrates that the fully deprotonated ligand L4– with high planarity in CuNet adopts a bis-µ2-η1: η1: η2 coordination mode to bind four Cu(II) to render a graphene-like network, which is further propped up to a 3D supramolecular framework through the hydrogen bonds between coordinated water and uncoordinated carboxyl oxygen. Considering its highly planar structural feature and excellent antibacterial properties of Cu(II), the DNA binding and antibacterial performance were explored. The UV-Visible absorption titration and EB-DNA competition determination exhibited that CuNet bound DNA in an intercalation mode with the higher binding constant Kb of 2.42 × 105 M− 1, and the comparable quenching constant Ksv of 1.62 × 104 M− 1 upon compared with the documented DNA linkers. In addition, the antibacterial activity test demonstrates that CuNet exhibits comparable inhibitory effect on Escherichia coli with that of cefradine at the concertation of 0.70 mg/mL. This work has certain significance for the development of metal drugs.
Coping styles and loneliness among patients undergoing hematopoietic stem cell transplantation: the mediating role of self-consistency and congruence
Authors: Gu Jiaxin , Luo Lingping , Hu Yue , Wei Lei , Huang Zhixuan , Gu Dawei , Li Ming
Published: April 2023

Purpose To evaluate the mediating effect of self-consistency and congruence on the relationship between coping styles and loneliness among patients undergoing hematopoietic stem cell transplantation in protective isolation.Methods This study adopted a cross-sectional descriptive survey. A total of 214 hematopoietic stem cell transplantation of patients in protective isolation were recruited at seven hematological centers in China from January 2022 to May 2022.Results Our results showed that self-consistency and congruence mediated the relationship different coping styles (i.e. confrontation, avoidance, and resignation) and loneliness in the patients. Among participants, coping styles of confrontation and avoidance were negatively associated with loneliness.Conclusion When patients are admitted to laminar flow wards, nurses should be concerned about their loneliness sincerely. We recommend paying particular attention to the role of self-consistency and congruence in alleviating the level of loneliness in the patients. Meanwhile, clinical nurses should be oriented towards encouraging the patients to avoid stress temporarily, in addition to taking a positive approach to coping with stress during protective isolation.
Preparation and evaluation of Ir base anode for proton exchange
membrane water electrolysis
Authors: Yazdani Mohammadreza
Published: April 2023

In this project, first, the electrochemical behavior of the catalysts RuO2 and Ir (50)/RuO2 (50) With tests CV, LSV, EIS, and CA was Checked out. From the results of the tests, the catalyst is mixed with an equal ratio of Ir and RuO2 as a suitable catalyst for use in the anode proton exchange membrane water electrolysis is Selected.
Synthesis and characterization of amine functionalized cellulose nanogel for transdermal drug delivery
Authors: Arockiaraj Antoniyar , Sundaramoorthy Subramanian
Published: April 2023

This study presents the synthesis and characterization of an amine-functionalized cellulose nanogel (AFCNG) for potential biomedical applications. AFCNG was synthesized using a combination of acid hydrolysis, TEMPO oxidation, and EDC/NHS-mediated coupling via amide linkage. Biodegradable AFCNG was formulated with a mean size of 74 nm through a regeneration process. Characterization of AFCNG was performed using various techniques such as FTIR spectroscopy, XRD, XPS, Zeta potential, DLS, HRSEM and TGA. The results revealed that AFCNG was amorphous, highly stable in colloidal form, and had higher degradation temperature and water absorption capacity. Biodegradation of AFCNG was also assessed by incubating it with lysozyme for five weeks, which resulted in a degradation level of 83%. Furthermore, hemo-compatibility and cytotoxicity properties of AFCNG were evaluated, and the results showed that it was hemo-compatible and non-toxic to 3T3 cells by cellular morphology assessment with DAPI staining. Curcumin-loaded AFCNG exhibited high cytotoxicity to B16-F10 cells, suggesting its potential as a transdermal drug delivery system for skin cancer treatment. The study concluded that AFCNG possesses the necessary characteristics to serve as a carrier for transdermal drug delivery applications.
Body colour drives optimal insect phenology via thermoregulation
Authors: Fernandez Roberto Novella , Brandl Roland , Pinkert Stefan , Zeuss Dirk , Hof Christian
Published: April 2023

Phenology, the seasonal timing of life events, is an essential component of biodiversity which partly results from species´ life cycle synchronisation to optimal seasonal moments1. The mechanisms involved are, however, complex2–4and understudied which limits our ability to predict biodiversity responses to global change drivers5. Thermoregulation is crucial for shaping diversity patterns, particularly in ectotherms such as insects. Dark-bodied species are able to inhabit colder areas due to their higher absorbance of solar radiation – a pattern known as Thermal Melanism Hypothesis (TMH). Thermal melanism is well supported to drive spatial variation of insect diversity6, but whether it also may influence phenological patterns remains unexplored. Here we show, using a unique dataset of thousands of spatio-phenologically explicit dragonfly and damselfly assemblages, that dragonfly body colour lightness patterns respond to seasonal variation of solar radiation, with darker early- and late-season assemblages and lighter mid-season assemblages. This suggests that colour-based thermoregulation can determine insect phenology in relation to optimal seasonal conditions. We also show that the phenological pattern of dragonfly colour lightness advanced significantly over the last 30 years. Together with static nature of solar radiation, our results suggest that global warming may drive flight periods to suboptimal seasonal conditions. Our findings open a new research avenue for a more mechanistic understanding of phenology and spatio-phenological impacts of climate warming on insects and other ectotherms.
Geistergespräch
Authors: Bazzi Danielle , Bräunlein Peter J. , Frateantonio Christa , Jebens Holger , Lange Thomas , Münzel Mark , Rodemeier Susanne , Streck Bernhard , Voss Ehler
Published: April 2023

Gespräch
Acquisition and display ethics
Authors: Jallo Zainabu , Jebens Holger
Published: April 2023

Conversation
Julia Bärnighausen et al. (Hrsg.): Foto-Objekte. Bielefeld 2020
Authors: Högner Bärbel
Published: April 2023

Buchbesprechung
Abordagem Cirúrgica de Hemangioma de Língua: Relato de Caso
Authors: Otaviano Leticia Thais , Bohneberger Gabriela , Garbin Júnior Eleonor Álvaro
Published: April 2023

Os hemangiomas são neoplasias vasculares benignas que podem acometer a cavidade oral. Podendo ser vistas, principalmente, nos lábios, língua, mucosa jugal e palato. Se caracterizam como lesões de coloração vermelho intenso ao aspecto arroxeado, de superfície lisa ou nodular, com extensão variável. Diversas modalidades de tratamento são descritas na literatura como escleroterapia, crioterapia, corticosteroides tópicos e/ou sistêmicos, remoção cirúrgica e terapia de fotocoagulação a laser. Este artigo tem como propósito relatar um caso de hemangioma em dorso de língua o qual foi optado por uma abordagem cirúrgica da lesão por apresentar interferência com as funções fisiológicas de deglutição, mastigação e fala da paciente. Após o período de controle de seis meses, manteve-se função habitual da língua, não havendo quaiquer sinal de recidiva da lesão.
Temperature dependence of quasiparticle interference in $d$-wave superconductors
Authors: Al Rashid Harun , Goyal Garima , Akbari Alireza , Singh Dheeraj  Kumar
Published: April 2023

We investigate the temperature dependence of quasiparticle interference in the high T_cTc-cuprates using an exact-diagonalization + Monte-Carlo based scheme to simulate the dd-wave superconducting order parameter. The quasiparticle interference patterns have features largely resulting from the scattering vectors of the octet model at lower temperature. Our findings suggest that the features of quasiparticle interference in the pseudogap region of the phase diagram are also dominated by the set of scattering vectors belonging to the octet model because of the persisting antinodal gap beyond the superconducting transition T_cTc. However, beyond a temperature when the antinodal gap becomes very small, a set of scattering vectors different from those belonging to the octet model are responsible for the quasiparticle interference patterns. With a rise in temperature, the patterns are increasingly broadened.
Evaluation of PERSIANN-CCS-CDR, ERA5, and SM2RAIN-ASCAT rainfall products for rainfall and drought assessment in a semi-arid watershed, Morocco
Authors: Najmi Adam , Igmoullan Brahim , Namous Mustapha , El Bouazzaoui Imane , Brahim Yassine Ait , El Khalki El Mahdi , Saidi Mohamed El Mehdi
Published: April 2023

Satellite-based precipitation products, with simultaneously high spatial and temporal resolutions, are mostly needed to assess climate change repercussions. Previous research used datasets neglecting either good temporal or good spatial resolution, PERSIANN-CCSCDR, ERA5, and SM2RAIN-ASCAT are some of the projects aiming to remedy these limitations. This study's goal is to evaluate the accuracy of the PERSIANN-CCS-CDR, ERA5, and SM2RAIN-ASCAT at a monthly scale and their suitability for drought assessment in a Moroccan semiarid watershed. Several statistical indices were computed, the drought SPI was calculated using PERSIANN-CCS-CDR estimates, ERA5 products, and observed records as an input in the SPI formula using Gamma distribution to simulate drought from 1983 to 2017. The preliminary comparison and evaluation results of PERSIANN-CCS-CDR estimates and ERA5 datasets showed good CC on a basin scale for monthly precipitation, with a slight overestimation of the observed precipitation shown by the PBIAS. The NSE scored 0.41 for PERSIANN-CCS-CDR and 0.72 for ERA5. The results for SM2RAIN-ASCAT showed an overestimation of the observed precipitation data. At the basin scale, the SPI3 correlation coefficients between the PERSIANN-CCS-CDR monthly estimates and observed gauge rainfall data were greater than 0.67, and the RMSE was closer to 0, outperforming ERA5 in the SPI3 evaluation.
Performance of Potato Variety Rolpa Local (Solanum tuberosum L.) under Different Mulching Conditions and Zinc Levels at Rolpa, Nepal
Authors: Aryal Muna , Pandey Krishna Raj , Dhakal Suman , Tumbapo Sanjeev , Joshi Yagyaraj
Published: April 2023

Use of the right mulching techniques is a crucial first step in replacing the issues with irrigation and weed infestation in potato production. To assess the performance of potatoes at two doses of zinc under different mulching conditions, a field experiment was laid out in a two-factorial, randomized complete block design (RCBD) comprising eight treatments with three replications each. The variety used was Rolpa local. The first factor consisted of three mulching materials: plant residue (M1), black plastic (M2), silver on black plastic (M3), and a control plot (M0), whereas the second factor compromised two levels of zinc (0 kg/ha and 4 kg/ha). Both plastic mulches were found to have a significant influence on germination rate during the field research; however, all other observations for growth and yield parameters, such as plant height, tuber number, tuber weight, and yield per plant, were significantly superior in the silver on black plastic. The highest germination percentage was observed in black plastic mulch (94.67 %). However, all other observations for growth and yield parameters were found to be significantly superior in the silver on black plastic mulch condition, with plant height (87.28 cm), leaf count (145.70), number of tubers per plant (22.16), and a total yield of 21.83 t/ha. Similarly, all the yield-attributing characters were found to be significantly different among zinc levels, with the highest total yield of 17.70 t/ha at 4 kg/ha of zinc. Silver on black plastic mulch and 4 kg/ha of zinc level resulted in the highest benefit-cost (B:C) ratios of 3.18 and 2.23, respectively. The results showed that using silver on black plastic mulch with a zinc level of 4 kg/ha improved both vegetative growth and potato yield, with favorable B:C ratios resulting in higher profitability. Thus, to maximize profit, it would be advantageous to utilize silver on black plastic mulch with 4 kg/ha of zinc.
Véu de ignorância e história constitucional
Authors: Bartolomé Clavero
Published: April 2023

Este ensaio, Véu de ignorância e história constitucional, poderia ser intitulado de outra forma, cunhando um neologismo: Multicon-tratualismoe história constitucional. O forte renascimento da doutrina do contrato social durante as últimas décadas, impulsionado por A Theory of Justicede John Rawls (1971) como fundamento para a igualdade entre indivíduos, tendendo a um véu de ignorância sobre adiversidade de condições de qualquer tipo, produziu uma reação em cadeia inesperada, trazendo à tona contratos sociais profundamente desiguais no plural. O gatilho foi, em 1988, com The Sexual Contractde Carole Pateman, na medida em que ele desafiou completamente o princípio da ignorância para a realização da justiça. Ela revelou o significado da ordem familiar como o espaço político no qual a subordinação da mulher está entrincheirada. Além disso, ela destacou como o contratualismo clássico, desde Locke, assumiu e expôs o poder marital como o primeiro dos poderes em contraste com o contratualismo atual que, desde Rawls, veste seu véu de ignorância sobre os condicionamentos familiares do status da mulher, mesmo em tempos de direitos. Nesta linha, Charles Mills continuou em 1997 com seu The Racial Contract, contrastando igualmente a transparência do contratualismo clássico com a opacidade do supremacismo atual em relação a todo o conjunto de uma subordinação racializada em base colonial. Há ainda mais. Em 2009, Pateman e Mills tentaram integrar suas respectivas visões em uma categoria abrangente de Contrato de Subordinação. Então, em 2015, The Capacity Contractde Stacy CliffordSimplican surgiu argumentando que as suposições supremacistas sobre a capacidade do indivíduo estão na base de todos os contratos de subordinação. Outros contratos, como o Contrato Geracionale o Contrato de Espécie ou animal, foram acrescentados. Assim, finalmente temos um multicontratualismo nos antípodas do contratualismo. Este ensaio argumenta que a historiografia constitucional dominante foi desenvolvida sob o paradigma da cegueira monocontratualista e que, portanto, as perspectivas oferecidas para o passado pelo multicontratualismo podem abrir horizontes não menos inesperados.
A qualitative cross-case analysis of older adults’ acceptance and resiliency behaviors amidst the COVID-19 pandemic crisis
Authors: Feliciano Evelyn E. , Feliciano Alfredo Z. , Alanazi Wedad A. , Fernandez Zenaida S. , Sembrano Karen D. , Feliciano Joan Russel D. , Cabanayan Ma. Teresa T. , Policarpio Brenda B. , Ligawen Jerry P.
Published: April 2023

Resilience has been identified as a dynamic process of sustaining healthy acceptance, adaptation, and effective coping strategies – multiplicity within the aging population is broadly acknowledged. Recognize the concept of resiliency with acceptance in aging interposes during successful aging. Seven 65-75-year-old adult purposive samples were interviewed, and data were collected, extracted, analyzed, and validated with four neutral major themes and 12 supporting subthemes using Colaizzi's method. The study was designed to validate a proposition in the aging-related resiliency theory, which states that when risks and adversities of aging are accepted, older adults tend to use adaptive strategies and supportive resources to improve their coping and resilience. Seven older adults (65-75 years old) purposive samples were interviewed, and data were collected, extracted, analyzed, and validated with four neutral major themes and 12 supporting subthemes using Colaizzi's method. During the COVID-19 pandemic, it is essential to include healthcare interventions that may augment acceptance and resilience in a manner of promoting older adults' healthy aging. It is also important to provide guidelines on how to reduce the negative effects on older adults during the pandemic.