bluuebunny/crossref_metadata_2025 huggingface dataset:
State Regulation of Tourist Activity in View of In-Country Travel Development: Theory and Practice
Authors: Donskova L. I. , Barannikov A. L. , Makarov A. A.
Published: June 2023

The analysis of issues connected with state regulation of tourism is acute for the development of in-country travel, especially in previous years due to crises in society, economy and politics. The goal of the research is to characterize the relations of tourism with different spheres of life on the basis of the idea of tourism as a social and economic system and to work out indicators of its efficiency (social and economic). In the system of management in order to support the balance in state administrating and market relations indicators of social and economic efficiency were formulated, the authors pay special attention on social effectiveness and ecological stability. Examples of empiric data concerning state measures of supporting tourism today demonstrate the impact of economic and social factors. Results of estimating trends and regularities of in-country travel with regard to Russian conditions should be taken into account in forecasting and planning the field of tourism and in state regulation of tourism in developing policy in travel.
Assessing the Potential of Using Artificial Intellect for Governing the Organization (illustrated by the Transportation and Logistics Holding Company)
Authors: Ulanov A. A. , Ulanov A. Yu.
Published: June 2023

The article provides results of the experiment in the form of an interview with chat-bot based on artificial intellect (AI) ChatGPT dealt with governing the transportation and logistics holding company. The research showed that AI systems had reached such a level of development, which allows us to use them for solving problems of organizational and strategic governance of the company. The system can give adequate answers to questions connected with various aspects of management, formulate suggestions and identify promising trends for strategic development. Chat-bot that deals with preliminary preparation of the material can be used to resolve analytical problems in order to save time of profile specialists. However, use of such systems can cause risks of sensitive information leakage and making incorrect decisions on the basis of wrong data. In spite of high assessment of such system potential, transportation and logistics companies and other organizations should use relevant technology with care.
Crianças negras e estudos culturais
Authors: Matheus do Rosário Corrêa Antonio , Amorim dos Santos Raquel , Sarraf Pacheco Agenor
Published: June 2023

Este artigo objetiva investigar a articulação entre as crianças negras e o campo de conhecimento dos Estudos Culturais em artigos de revistas científicas brasileiras no período de 2010 a 2020. O método se caracteriza pela abordagem qualitativa com aplicação de pesquisa bibliográfica e realização de Estado da Arte preliminar fundamentado nos processos de levantamento, mapeamento e análise de artigos com Qualis A1 e A2 (Educação e Interdisciplinar), com visualização do estado do conhecimento e perfil editorial das revistas. O recorte temporal compreende os últimos 10 anos de produção, considerando o Estatuto da Criança e do Adolescente. A etapa analítica está baseada nos Gêneros Discursivos do Círculo de Bakhtin (2016). Localizou-se cinco artigos sobre crianças negras no Brasil, sendo estruturadas as categorias: 1) crianças negras e racismo, com abrangência às meninas e meninos negros na literatura infantil, infâncias diante o racismo e interlocuções entre raça e Educação Infantil; 2) crianças negras e identidade, com temas referentes as crianças em iconografias no Brasil (séc. XIX e XX) e constituição da negritude na infância. Conclui-se que há necessidade de ampliação de publicações sobre a temática e, principalmente, que contemplem os Estudos Culturais como campo epistemológico, sendo uma possibilidade a publicação de dossiês temáticos, para produção de conhecimento e divulgação científica
Transcriptomic Analysis of lncRNAs and their mRNA Networks in
Cerebral Ischemia in Young and Aged Mice
Authors: Zeng Yuanyuan , Xue Tengteng , Zhang Dayong , Lv Manhua
Published: June 2023

Background:

Ischemic stroke comprises 75% of all strokes and it is associated with a
great frailty and casualty rate. Certain data suggest multiple long non-coding Ribonucleic Acids
(lncRNAs) assist the transcriptional, post-transcriptional, and epigenetic regulation of genes expressed
in the CNS (Central Nervous System). However, these studies generally focus on differences
in the expression patterns of lncRNAs and Messenger Ribonucleic Acids (mRNAs) in tissue
samples before and after cerebral ischemic injury, ignoring the effects of age.

Methods:

In this study, differentially expressed lncRNA analysis was performed based on RNAseq
data from the transcriptomic analysis of murine brain microglia related to cerebral ischemia
injury in mice at different ages (10 weeks and 18 months).

Results:

The results showed that the number of downregulate differentially expressed genes
(DEGs) in aged mice was 37 less than in young mice. Among them, lncRNA Gm-15987, RP24-
80F7.5, XLOC_379730, XLOC_379726 were significantly down-regulated. Then, Gene Ontology
(GO) enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis indicated that
these specific lncRNAs were mainly related to inflammation. Based on the lncRNA/mRNA coexpression
network, the mRNA co-expressed with lncRNA was mainly enriched in pathways, such
as immune system progression, immune response, cell adhesion, B cell activation, and T cell differentiation.
Our results indicate that the downregulation of lncRNA, such as Gm-15987, RP24-
80F7.5, XLOC_379730, and XLOC_379726 in aged mice may attenuate microglial-induced inflammation
via the progress of immune system progression immune response, cell adhesion, B cell
activation, and T cell differentiation.

Conclusion:

The reported lncRNAs and their target mRNA during this pathology have potentially
key regulatory functions in the cerebral ischemia in aged mice while being important for diagnosing
and treating cerebral ischemia in the elderly.
Exploring the Biochemical Mechanisms of Fluoroquinolone Compounds
against Tuberculosis by Utilizing Molecular Docking and Quantitative
Structure-amino Acid Relationship
Authors: Alam Muneer , Fatima Zeeshan , Nandi Sisir
Published: June 2023

Background:

Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis
(Mtb). It is one of the leading causes of death of 1.5 million people each year. TB can be treated by
directly observed treatment short course (DOTS), but due to multidrug-resistant (MDR) and extensively
drug-resistant (XDR) tuberculosis, consequences can be devastating if the single DOTS dose is missed by
the patient. MDR and XDR-TB require much more attention and time to control the infection. The longer
period of tuberculosis treatment has side effects and it is expensive.

Objectives:

This alarming condition demands the development of novel processes to diagnose the disease
in its early stage as well as to produce more promising antimicrobial chemotherapeutics. The current
study aimed to explore molecular mechanisms involving docking simulation-based quantitative structureamino
acid relationship (QSAAR) in order to have a better understanding of the interactions between the
fluoroquinolones and Mtb DNA gyrase.

Methods:

In this study, 24 fluoroquinolone (FQ) compounds present in the literature were selected and
docked against the Mtb DNA gyrase. Further, the relationship between the minimum inhibitory concentration
of the compounds and interacting amino acids was assessed using QSAAR.

Results:

The study has established a novel method of formulating a quantitative structure-amino acid
relationship. A significant correlation (R-value=0.829) between biological activity and the docked amino
acid residues responsible for producing anti-tubercular activities has been obtained.

Conclusion:

The predicted residues captured in the developed model have been explored to report the
Mtb virulence.
Pathological Lung Ultrasound May Take Time to Resolve Despite Respiratory
Symptoms Improvement: A Pediatric Case Series Followed for Long
COVID
Authors: Klain Angela , Indolfi Cristiana , Dinardo Giulio , Contieri Marcella , Decimo Fabio , Miraglia del Giudice Michele
Published: June 2023

Background:

Long COVID affects 8 to 10 % of children. Currently, the COVID-19 fo-llow-up protocols in children include chest auscultation, collection of growth parameters, including weight, height and body mass index, execution of the six-minute walking test, basal spirometry, and afterwards, bronchodilation test and lung ultrasound.

Case Presentation:

In this paper, the authors describe a case series of long COVID followed up for 9 months at the Department of Pediatrics of the University Luigi Vanvitelli. The review of the lite-rature was performed on PubMed using the keywords COVID-19, follow-up, children, and lung ul-trasound. The aim of this article was to highlight the need to create custom follow-up programs for long Covid in children through the description of a case followed up at our Pediatric Department and a review of the current literature

Discussion:

The reversal of pathological lung ultrasound signs occurred in six or nine months des-pite the early improvement of respiratory symptoms and pulmonary function. There are limited stu-dies on the ultrasonography follow-up of kids with COVID-19 in the literature, and there are still no follow-up COVID-19 guidelines for paediatric population.

Conclusion:

Pathological lung ultrasound in children recovered from COVID-19, may take time to resolve; therefore, evaluating patients with lung ultrasound in the following months could be a ra-diation-saving approach useful for children who have fully recovered and have no warning signs.
Kikuchi-Fujimoto Disease in the Axilla after COVID-19 Vaccination: A Case Report
Authors: Baek Hye Jin , Cho Eun , Bae Kyungsoo , Jeon Kyung Nyeo , Moon Jin Il , Park Sung Eun , Lee Han Shin , An Hyo Jung
Published: June 2023

Background:

Kikuchi-Fujimoto disease (KFD) is a rare, self-limiting inflammatory condition of unknown etiology that is characterized by fever and painful lymphadenopathy. KFD commonly involves the posterior cervical region and very rarely occurs in the axilla.

Case Presentation:

We report on a case of KFD that presented 3 weeks after receiving the messenger ribonucleic acid-based coronavirus disease 2019 (COVID-19) vaccine. In this case, we suspected the lesions as COVID-19 vaccination-related lymphadenopathy on the initial ultrasonographic examination.

Conclusion:

Through this case report, we highlight that KFD should be considered in the differential diagnosis of patients with axillary lymphadenopathy who have undergone COVID-19 vaccination, as unusual side effects of COVID-19 vaccination have been increasingly reported in the literature owing to the rapid development of various COVID-19 vaccines during the pandemic period. In addition, we emphasize the importance of clinical suspicion in diagnosing KFD due to the fact that axillary involvement of KFD is extremely rare.
Development and Evaluation of Sulfobutylether-β-cyclodextrin Inclusion
Complexes of Etoricoxib for Enhancing Dissolution
Authors: Vishvakarma Vivekanand , Kaur Malkiet , Nagpal Manju , Maman Paramjot
Published: June 2023

Introduction:

Etoricoxib is a BCS class II drug with poor aqueous solubility and analgesic
and anti-inflammatory properties. Complexation with cyclodextrins is one of the widely used
methods, amongst others, for enhancing the solubility and bioavailability of drugs. In current research
work, inclusion complexes of etoricoxib using modified forms of cyclodextrin, i.e., captisol
were prepared using kneading, evaporation, and freeze-drying methods to improve the solubility
and dissolution characteristics.

Methods:

Etoricoxib inclusion complexes (ratio 1:1) were formulated using kneading, evaporation,
and freeze-drying methods. The formulated inclusion complexes were evaluated for phase solubility,
equilibrium solubility studies, Fourier transform infrared spectroscopy, powder X-ray diffraction,
scanning electron microscopy, differential scanning calorimetry studies, in vitro drug release,
similarity factor and in vivo studies.

Results:

The freeze-drying method produced inclusion complexes with the highest equilibrium solubility
(ten times that of the pure drug). Fourier transform infrared spectroscopy studies showed no
drug-polymer interaction. Differential scanning calorimetry and scanning electron microscopy studies
suggested the incorporation of the drug into inclusion complexes of cyclodextrin. In vitro dissolution
studies of kneading, evaporation and freeze-drying method inclusion complexes showed
66.53%, 79.13% and 88% drug release, respectively, in 3h, whereas pure drug exhibited 61.77%
drug release in 3 h. The f1 value obtained was less than 50, which is indicative of a significant difference
in release characteristics of kneading, evaporation and freeze-drying methods with that of
the marketed formulation. In vivo studies indicated that inclusion complexes formulated by the
freeze-drying method showed better analgesic and anti-inflammatory effects in comparison to formulations
prepared by kneading and evaporation methods.

Conclusion:

It is concluded that the formulation prepared by the freeze-drying method led to a significant
enhancement of dissolution and solubility rate of etoricoxib in comparison to the formulation
prepared by the kneading method and evaporation method.
Early Marriage and its Association with the Socioeconomic and Sociocultural Factors of Women in Sudan: A Predictive Model
Authors: Abdallah Ahmed Saied Rahama , Mohammed Mohammed Omar Musa , Mohamed Adel Ali Ahmed
Published: June 2023

Background:

Early marriage is spreading in Sudan, like in most African countries. Early marriage is defined as any marriage that happens before the age of 18. Early marriage is a human rights violation and has a huge negative effect, especially on girls.

Objectives:

The aim of this study was to assess the prevalence and determinants of socioeconomic and sociocultural factors associated with women's early marriage in Gezira state in Sudan.

Methods:

The study depended on primary data from Gezira state (2021). The study adopted the questionnaire as a tool for data collection. The questionnaire was designed to collect data on variables related the early marriage. The descriptive statistics, chi-square test, and logistic regression model were used to analyze the collected data.

Results:

The results revealed that the prevalence of early marriage among females in Gezira state was 54.9%, the prevalence of early marriage among rural areas was 57.3%, and there was a significant association between early marriage and unemployment. The result of the logistic regression model showed that there was a significant relationship between early marriage and the factors such as area, wealth index quantile, unemployment, and exposure to media. Whereas the model found an insignificant association between early marriage and the factors such as low financial condition leading to early marriage, early marriage is one of the signs of urbanization, immigrant cultures support early marriage, establishing a good maternal relationship between the child and the mother.

Conclusion:

Early marriage is widespread in Gezira state, and it is associated with socioeconomic and sociocultural factors.
The Difference in Mouthwash Side Effects of Persica and Chlorhexidine for Preventing Ventilator-induced Pneumonia among Patients Admitted to the Intensive Care Unit
Authors: Kiabi Farshad Hassanzadeh , Baradari Afshin Gholipour , Kiasari Alieh Zamani , Shahheidari Mahdi
Published: June 2023

Background:

Pneumonia is a common cause of morbidity and mortality in ICU patients under mechanical ventilation. In recent years the use of herbal mouthwashes, due to antimicrobial effects and fewer side effects, has been studied in reducing the incidence of ventilator-associated pneumonia (VAP). In this study, the effect of Persica mouthwash in the prevention of VAP in ICU patients was compared with chlorhexidine.

Methods:

This study is a double-blind, randomized clinical trial among ICU patients under mechanical ventilation. Fifty patients were divided into two groups, the control group used 10 ml Chlorhexidine 2.0%, and the intervention group used 10cc Persica as a mouthwash. The incidence of pneumonia, mortality, length of hospital stays, mechanical ventilation duration, CPIS (Clinical Pulmonary Infection Score), and SOFA (sequential organ failure assessment) score and complications were evaluated among the two groups.

Results:

The incidence of pneumonia, mortality, SOFA score, and CPIS in the two groups were not significantly different. Length of stay in the ICU and mechanical ventilation duration were also not significantly different in the two groups, p>0.05. Side effects with chlorhexidine were significantly more often than Persica (44% vs. 8%) p=0.008.

Conclusion:

The incidence of early pneumonia in patients with no baseline pneumonia did not differ with Persica and Chlorhexidine mouthwash. At the same time, the incidence of side effects caused by the use of Persica was significantly less.

Clinical Trial Registrations No.:

RCT2017022032676N1.
Kalanchoe pinnata (Patharchatta): A Therapeutic Boon to Mankind
Authors: Wadhwa Sapna , Boora Sanjit , Soniya Kumari , Yadav Suman , Kaushik Sulochana , Kumar Ramesh , Kaushik Samander
Published: June 2023

Bryophyllum pinnatum, commonly known as the “patharchatta,” belongs to the family of “Crassulaceae.” Bryophyllum pinnatum is often used to treat gallbladder stones and heal wounds. It possesses a lot of pharmacological properties, such as antioxidant, anti-cancerous, antimicrobial, antiviral, etc. It is an aromatic plant having a sweet and sour smell and is used as a herb. In different plant species, essential oils present in the leaves and other parts give them their unique smell and fragrance. Many phytochemicals have been isolated from this plant, like alkaloids, triterpenes, cardenolides, flavonoids, and bufadienolides, as well as lipids, steroids, and glycosides from vari-ous extracts. Among them, only some compounds have medicinal properties. In this review, we have analyzed the ADME properties of the phytochemicals present in the plant to identify which chemical can act as a drug candidate using the SwissADME server.
Trends of Software Development Methodologies Toward DevOps:
Analysis and Review
Authors: Narang Poonam , Mittal Pooja
Published: June 2023

Background:

The trend of software development has always been challenging for industry
experts and software developers. There is tremendous growth in software development
methodologies under the influence of evolving technologies and the rising demands of society.
The 2019 pandemic forced software developers to shut down their offices and begin working
from home, thereby, highlighting the critical necessity for a shared development and operations
teams platform. As a result, the development trend moves from waterfall and Agile towards
DevOps.

Objective:

The objective of the research is to review and comparatively analyze the availability
factor of different selective and required features in software development methodologies. Software
development industries will be benefited in appropriate methodology selection based on the
requirement.

Methods:

The analysis is based on review of different development methodologies based on existing
literature study, Google, and Stack Overflow Trends followed by tabular comparison of
Waterfall, Iterative, Prototype, Spiral development models under Traditional and Rapid Application
Development (RAD), Scrum, Kanban, XP for Agile methods with DevOps automation culture
on essential features.

Results:

The moving trend towards DevOps, from Traditional and Agile development, demonstrate
the most recent market swings for these models. Although Traditional models adhere to
outdated software development methodologies, they are included in this high-quality survey and
evaluation because of their widespread use in the software industry and prominent researcher’s
survey work.

Conclusion:

Software developers, students, and researchers will all find it simple to comprehend
the workings of development processes as a result of this analytical review. Additionally, it will
also make it easier for these target audiences to choose relevant and effective models for software
development.
Perancangan wayang Isekai sebagai alternatif pentas wayang untuk generasi muda
Authors: Arif Novida Nur Miftakhul
Published: June 2023

Merespon masalah mental yang kerap dialami oleh generasi muda melalui media pendidikan karakter yang memanfaatkan pentas wayang merupakan tujuan utama riset dan perancangan karya Wayang Isekai. Masalah mental dan menghilangnya pentas wayang selama pandemi Covid-19 merupakan persoalan aktual yang perlu direspon secara kreatif seperti dengan wayang kontemporer. Metode produksi film atau multimedia digunakan dalam eksperimen ini, yaitu pra produksi, produksi dan paska produksi. Di dalamnya juga melibatkan observasi, wawancara, studi pustaka, eksplorasi dan inovasi. Hasil dari riset dan perancangan media ini adalah Wayang Isekai, eksperimen pentas daring yang memadukan pentas wayang, animasi dan live action dengan cerita yang merepresentasikan perjalanan batin menuju self-awarenes. Wayang Isekai mampu menjadi alternatif media penyampai pesan kebaikan seperti pendidikan karakter. Kata Kunci: wayang, kontemporer, generasi muda, masalah mental  THE DEVELOPMENT OF WAYANG ISEKAI AS ALTERNATIVE WAYANG PERFORMANCE FOR YOUNG GENERATION Abstract Responding the mental issues that are often experienced by the young generation through the medium of character education that utilizes wayang performance is the main goal of the research and development of Wayang Isekai. A contemporary wayang is a creative way to respons mental issues and the disappearance of puppet performances during the Covid-19 pandemic. Film or multimedia production method was used in this experiment, namely pre-production, production and post-production. It also involved observation, interviews, literature studies, exploration, and innovation. The result of this research is Wayang Isekai, an online performance that combined puppetry, animation and live action with stories that represent the inner journey towards self-awareness. Wayang Isekai is able to become an alternative medium for conveying positive messages such as character education. Keywords: wayang, contemporer, young generation, mental issue
Eklektik filosofis, teknis, dan psikologis bermain biola dalam pengembangan pembelajaran musik di Indonesia
Authors: Fu'adi Fu'adi , Walidaini Birul , Agustianto Agustianto , Sritanto Sritanto
Published: June 2023

In learning the violin, there are various kinds of challenges and obstacles, both technical and non-technical. Strong motivation is needed, supported by appropriate learning methods so that students can develop into capable violinists. This article outlines the philosophical, technical, and psychological aspects of violin learning by world-class violin pedagogues, which are then analyzed in an eclectic manner in order to obtain new approaches that can be applied to develop violin learning in Indonesia. The literature review method is used to select important aspects used in violin learning. The research results show important points of philosophical study in learning the violin include philosophy in starting to learn the violin, mental approach, emotional aesthetics, and talent in music. Technical and psychological studies include body position in playing the violin, sound production, intonation, vibrato, legato, musical nuances, psychological musicians, and the repertoire played. It can be interpreted that these selected and analyzed philosophical, technical, and psychological values of how to play the violin can become the basis for understanding and efforts to build students' capabilities in playing the violin in a comprehensive manner, in accordance with the Indonesian cultural background. Keywords: Eclectic, philosophy, violin technique, musical learning
Caregiver needs and perception of data sharing for research through mHealth in pediatric asthma: a cross-sectional survey (Preprint)
Authors: Meng Glen , Jan Ali Maliha , Tse Sze Man
Published: June 2023

BACKGROUND

Asthma is the most common chronic respiratory disease of childhood. Caregivers often report lacking knowledge in several aspects of asthma management at home. While the use of mHealth tools such as mobile applications could facilitate asthma self-management and simultaneously collect data for research, few studies have explored the features that caregivers would like to see in such a tool and their perception for data sharing.

OBJECTIVE

This study evaluated caregivers’ perceived knowledge gaps in asthma management, their perception of certain features and resources that should be included in a potential mobile application, and any concerns that they may have on data sharing for research, including privacy and security.

METHODS

In this cross-sectional study, we surveyed 200 caregivers of children aged 1-13 years with asthma followed at a pediatric tertiary care center in Montreal, Canada. Anonymous data was collected through the institutional online survey platform. We collected the participant’s answers using a 5-category Likert scale (completely agree, agree, neither agree nor disagree, disagree, completely disagree), multiple choice questions, and free text questions on the topics above. Descriptive statistics were performed and answers were compared between caregivers of preschool- and school-aged children.

RESULTS

Participating children had a mean(standard deviation) age of 5.9(3.4) years, with 54% aged ≤5 years and 46% >6 years. Overall, caregivers reported having adequate knowledge about asthma and asthma self-management. Nonetheless, they identified several desirable features for a mobile application focused on asthma self-management. The most frequently identified features include receiving alerts about environmental triggers of asthma (76.9%), having videos demonstrating symptoms of asthma (66.8%), and being able to log their child’s asthma action plan in the application (66.8%). Interestingly, more caregivers of preschool-aged children preferred textual information compared to caregivers of school-aged children (P=.008 for explaining asthma and P=.005 for the symptoms of asthma). Caregivers were generally highly in favor of sharing data collected through a mobile application for research.

CONCLUSIONS

Caregivers of children with asthma in our study identified several desirable educational and interactive features to have in a mobile app for asthma self-management. These findings provide a foundation for designing and developing mHealth tools that are relevant to caregivers of children with asthma.
Home Care Program with Telemonitoring for Patients Undergoing Peritoneal Dialysis in South Korea: A Cost-Utility Analysis (Preprint)
Authors: Kim KyungYi , Kim Tae Hyun , Shin Jaeyong , Jang Suk-Yong , Kim Hyung Woo , Kim Beom Seok , Lee Sang Gyu
Published: June 2023

BACKGROUND

The COVID-19 pandemic spurred the rapid adoption of a wide array of digital health technologies. To improve the quality of life by enhancing access to care, the Ministry of Health and Welfare of Korea has initiated a home care program that includes face-to-face educational consultation and remote patient monitoring. This new home care program should be evaluated to verify its long-term economic effectiveness.

OBJECTIVE

To examine the effectiveness of a digital health-based home care program, study investigated its cost-effectiveness by conducting a cost-utility analysis of a home care program for patients with end-stage renal disease (ESRD) undergoing peritoneal dialysis (PD) in a tertiary care hospital.

METHODS

The study constructed a Markov model to evaluate the lifetime cost-effectiveness of the PD home care program. Cohorts of 1,000 patients aged 50 years with a PD health state were simulated to make a state transition at one-year cycles. The effectiveness variable was measured as quality-adjusted life years (QALYs), and a cost-utility analysis was conducted with a limited societal perspective. The willingness-to-pay (WTP) threshold was set to KRW 40,043,036 (GDP per capita) per increasing 1 QALY, and the discount rate of 4.5% was applied for both QALYs and costs. A half-cycle correction was reflected, and the main outcomes were the incremental cost-effectiveness ratio (ICER) and incremental net monetary benefit. Scenario, sensitivity, and expected value of perfect information (EVPI) analyses were performed to reflect the uncertainty.

RESULTS

In the base case analysis, the ICER was calculated as KRW 4,571,500 per QALY. Regardless of the scenarios, the results of the base case analyses were in the range of the WTP threshold. A one-way sensitivity analysis was performed, and the most sensitive parameters were the costs of PD (home care) and PD (usual care) in every scenario. For the outcome of the Monte Carlo simulation (10,000 iterations), the home care group represented an optimal overall strategy, with probabilities of 62.05% in Scenario 1, 59.95% in Scenario 2, 61.70% in Scenario 3, and 89.41% in Scenario 4. The WTP threshold where the probabilities of the home care group were optimal at above 50% was KRW 7,380,000. Finally, EVPI was measured and showed an additional KRW 14,818,960 per patient gained when all parameter information was obtained without uncertainty.

CONCLUSIONS

This study evaluated the cost-effectiveness of a novel home care program for patients undergoing PD in Korea and demonstrated that the ICER was under the WTP threshold. Therefore, implementing a home care program for these patients may be cost-effective.

CLINICALTRIAL

N/A
Portuguese Version of the Oral Frailty Index-8: Instrument Validation Study (Preprint)
Authors: Corrêa Laura , Júdice André , Scoz Robson , Machado Vanessa , Mendes José João , Proença Luís , Botelho João , Ferreira Luciano
Published: June 2023

BACKGROUND

The concept of oral frailty has gained scientific and clinical relevance in recent years, and early detection can facilitate timely intervention to manage its progression. The Oral Frailty Index-8 (OFI-8) was developed to assess community-dwelling older adults at risk for oral frailty.

OBJECTIVE

This study aims to investigate the psychometric validity of the OFI-8 in the Portuguese population, named the Portuguese version of the OFI-8 (OFI-8-PT), which may serve as a reference for future studies related to longevity and oral function.

METHODS

This study included 2 main phases, involving patients aged 60 years or older, Portuguese speakers, and those who consented to participate in the study. First, the researchers translated and cross-culturally adapted the original questionnaire to make it suitable for native Portuguese speakers. The translated tool was then assessed for psychometric validation, which consisted of test-retest reliability, internal consistency, construct validity, and sex invariance measurement.

RESULTS

A total of 159 older adults participated in the baseline survey, with almost equal numbers of male (n=79, 49.7%) and female participants (n=80, 50.3%). The OFI-8-PT demonstrated good reliability (Cronbach α=0.95) and construct validity (goodness-of-fit index=0.96; comparative fit index=0.85; and root mean square error of approximation=0.05, 90% CI 0.00-0.09). The study found sex invariance, indicating that the OFI-8-PT is equally valid for male and female participants, and the tested-retest reliability of the OFI-8-PT was good, indicating consistent results over time.

CONCLUSIONS

The OFI-8-PT showed psychometric validity and good reliability to be used in the Portuguese population.
The Rationale of an Augmented Reality Mobile e-Health Exergame to Increase Physical Activity for Patients with Heart Failure (Preprint)
Authors: Berglund Erik , Klompstra Leonie , Orädd Helena , Fallström Johan , Strömberg Anna , Jaarsma Tiny , Berglund Aseel
Published: June 2023

BACKGROUND

Physical activity is important for everyone to maintain and improve health, especially for people with chronic diseases. Mobile exergaming has the potential to increase physical activity and specifically to reach people with poor activity levels. However, commercial mobile exergames are not specially designed for older people with chronic illness.

OBJECTIVE

The objectives of this study is to describe the rationale of a mobile exergame for inactive older people who have been diagnosed with heart failure. The goal of the exergame is to increase physical activity by increasing the time a person spends walking each day by at least 10 minutes.

METHODS

The rationale behind the design of the mobile exergame is based on gamification components, gamification elements, and gamification principles related to the design and implementation of gamification strategies that can be applied in cardiovascular care. The exergame was developed using three gamification components, five gamification principles, and four gamification elements.

RESULTS

The Heart Farming mobile exergame is about helping a farmer take care of and expand a farm, with these activities taking place while the patient walks in the real world. The exergame is developed using augmented reality so it can be played both indoors and outdoors. The augmented reality technology is used to track the patients’ movement rather than to augment the user interface. The exergame is adapted to individual preferences and physical condition.

CONCLUSIONS

A mobile exergame to support patients’ own individual preferences and conditions regarding where, how, when, and how much to play can be developed by applying AR technology to detect patients’ physical activities both indoors and outdoors. AR is used to reveal patients’ movements in the real world and interpreting them into events in the exergame.
Effectiveness of tele-pulmonary rehabilitation as a preventative program in individuals at risk of Chronic Obstructive Pulmonary Disease (COPD) from Artificial intelligence (AI) predictions (Preprint)
Authors: Chuatrakoon Busaba , Kongsawasdi Siriphan , Wantanajittikul Kittichai , Sriburee Sompong , Konghakote Supatcha
Published: June 2023

BACKGROUND

Chronic obstructive pulmonary disease (COPD) is a major public health concern. Early detection and prevention interventions are crucial. Artificial intelligence (AI) developed to predict COPD risk. Tele-pulmonary rehabilitation (Tele-PR) shows promise in improving outcomes. However, its preventive efficacy in individuals at risk of COPD remains unexplored.

OBJECTIVE

To examine the effectiveness of a Tele-PR program on exercise capacity, disease-related symptoms, muscular strength, and COPD risk rate in individuals at risk of COPD based on AI predictions.

METHODS

Of 286, 38 individuals at risk of COPD from AI predictions were eligible and allocated to either an intervention or control group (20 and 18 per group). The intervention group received a Tele-PR program, consisting of the exercise regimen three times per week for twelve weeks. The control group was given verbal information about the disease and prevention advice for self-management. Outcomes were exercise capacity measured by a six-minute walk test (6MWT), disease-related symptoms measured by the modified medical research council dyspnea (mMRC) scale and COPD assessment test (CAT), back and leg strength measured by a dynamometer, and COPD risk rate evaluated by AI predictions. All outcome measures were assessed at baseline and after the 12-week intervention.

RESULTS

All participants completed the trial with no adverse events reported. At the end of the 12-week training, the Tele-PR group demonstrated significantly greater improvements in six-minute walk distance (6MWD), lower COPD risk rate than the control group (p = .011 and .024, respectively). There were no significant differences in other outcome measures.

CONCLUSIONS

The twelve-week Tele-PR program effectively improves exercise capacity and diminishes rate of COPD risk in individuals at risk of COPD predicted from the AI approach.

CLINICALTRIAL

None
Feasibility Study on Menstrual Cycles With Fitbit Device (FEMFIT): Prospective Observational Cohort Study (Preprint)
Authors: Lang Anna-Lena , Bruhn Rosa-Lotta , Fehling Maya , Heidenreich Anouk , Reisdorf Jonathan , Khanyaree Ifrah , Henningsen Maike , Remschmidt Cornelius
Published: June 2023

BACKGROUND

Despite its importance to women’s reproductive health and its impact on women’s daily lives, the menstrual cycle, its regulation, and its impact on health remain poorly understood. As conventional clinical trials rely on infrequent in-person assessments, digital studies with wearable devices enable the collection of longitudinal subjective and objective measures.

OBJECTIVE

The study aims to explore the technical feasibility of collecting combined wearable and digital questionnaire data and its potential for gaining biological insights into the menstrual cycle.

METHODS

This prospective observational cohort study was conducted online over 12 weeks. A total of 42 cisgender women were recruited by their local gynecologist in Berlin, Germany, and given a Fitbit Inspire 2 device and access to a study app with digital questionnaires. Statistical analysis included descriptive statistics on user behavior and retention, as well as a comparative analysis of symptoms from the digital questionnaires with metrics from the sensor devices at different phases of the menstrual cycle.

RESULTS

The average time spent in the study was 63.3 (SD 33.0) days with 9 of the 42 individuals dropping out within 2 weeks of the start of the study. We collected partial data from 114 ovulatory cycles, encompassing 33 participants, and obtained complete data from a total of 50 cycles. Participants reported a total of 2468 symptoms in the daily questionnaires administered during the luteal phase and menses. Despite difficulties with data completeness, the combined questionnaire and sensor data collection was technically feasible and provided interesting biological insights. We observed an increased heart rate in the mid and end luteal phase compared with menses and participants with severe premenstrual syndrome walked substantially fewer steps (average daily steps 10,283, SD 6277) during the luteal phase and menses compared with participants with no or low premenstrual syndrome (mean 11,694, SD 6458).

CONCLUSIONS

We demonstrate the feasibility of using an app-based approach to collect combined wearable device and questionnaire data on menstrual cycles. Dropouts in the early weeks of the study indicated that engagement efforts would need to be improved for larger studies. Despite the challenges of collecting wearable data on consecutive days, the data collected provided valuable biological insights, suggesting that the use of questionnaires in conjunction with wearable data may provide a more complete understanding of the menstrual cycle and its impact on daily life. The biological findings should motivate further research into understanding the relationship between the menstrual cycle and objective physiological measurements from sensor devices.
Faktor yang Berhubungan dengan Minat Masyarakat dalam Memanfaatkan Layanan PUSTAKA (Puskesmas Tanpa Antrean Kota Semarang)
Authors: Khoerunnisak Khoerunnisak , Arso Septo Pawelas , Kusumastuti Wulan
Published: June 2023

Latar   Belakang: Puskesmas Krobokan Semarang mempunyai antrean rawat jalan yang cukup banyak di tempat pendaftaran. Dalam mengatasinya, Puskesmas Krobokan menerapkan layanan Puskesmas Tanpa Antrean Kota Semarang (PUSTAKA) yang telah dikembangkan oleh Dinas Kesehatan Kota Semarang. Namun, dalam pelaksanaannya layanan ini belum dimanfaatkan secara optimal oleh masyarakat.Tujuan: Mengetahui hubungan antara kondisi fasilitasi, motivasi hedonis, nilai harga dan kebiasaan dengan minat masyarakat dalam memanfaatkan PUSTAKA.Metode: Penelitian kuantitatif ini menggunakan desain cross sectional. Teknik pengambilan sampel adalah accidental sampling dengan menggunakan kuesioner sebagai instrumen penelitian. Dalam penelitian ini dilakukan analisis univariat dan analisis bivariat dengan menggunakan uji chi-square. Pengumpulan data dilakukan secara kualitatif untuk menggali informasi lebih dalam terhadap responden.Hasil: Sebanyak 71,3% responden berminat dalam memanfaatkan layanan PUSTAKA. Terdapat hubungan antara kondisi fasilitasi, motivasi hedonis, nilai harga dan kebiasaan dengan minat masyarakat dalam memanfaatkan layanan PUSTAKA dengan p-value ≤ 0,05.Kesimpulan: Sebagian besar responden berminat menggunakan layanan PUSTAKA di Puskesmas Krobokan.
Pengaruh pasta gigi fluorida dan low-abrasive fluoridated terhadap kekasaran permukaan gigi pasca home bleaching karbamid peroksida 20%
Authors: Widyastuti Andina , Santosa Pribadi , Yulianto Heribertus Dedy Kusuma , Rinastiti Margareta , Enggardipta Raras Ajeng , Sulistyo Novia Sari
Published: June 2023

Bleaching merupakan prosedur pemutihan gigi yang pada saat ini banyak diminati oleh masyarakat. Salah satu efek bleaching adalah terjadinya peningkatan porusitas email sehingga gigi lebih rentan terhadap terjadinya karies. Remineralisasi diperlukan untuk meningkatkan kekerasan email, salah satunya dengan pemberian pasta gigi. Terdapat beberapa jenis pasta gigi yang beredar di pasaran, namun belum diketahui pasta gigi manakah yang terbaikuntuk digunakan pada pasien pasca bleaching. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan pasta gigi fluorida dan pasta gigi low-abrasive fluoridated terhadap karakteristik permukaan gigi pasca aplikasi home bleaching menggunakan karbamid peroksida 20%. Penelitian ini menggunakan spesimen berupa 20 gigi premolar rahang atas yang sudah dilakukan ekstraksi, kemudian diberi perlakuan penyikatan dengan akuades, pasta giginonfluorida, pasta gigi fluorida, dan pasta gigi low-abrasive fluoridated. Uji kekasaran permukaan dilakukan sebelum bleaching, setelah bleaching, serta penyikatan setelah bleaching. Hasil uji ANAVA dua jalur menunjukkan nilai p < 0,05 maka terdapat perbedaan yang signifikan pada kelompok perlakuan penyikatan gigi dan kelompok waktu pengujian kekasaran permukaan. Uji post-hoc multiple comparison test LSD menghasilkan terdapat perbedaaan kekasaran permukaan gigi yang bermakna antara kelompok penyikatan gigi dengan pasta gigi fluorida dan pastagigi low-abrasive fluoridated. Proses bleaching pada penelitian ini menunjukkan peningkatan kekasaran permukaan email gigi secara signifikan. Perlakuan penyikatan gigi menurunkan kekasaran permukaan email secara bermakna. Berdasarkan hasil penelitian dapat diambil kesimpulan bahwa proses penyikatan dengan pasta gigi pasca bleaching dapat mengembalikan kondisi kekasaran permukaan email yang mendekati saat sebelum dilakukan bleaching.Penggunaan pasta gigi fluorida dan pasta gigi low-abrasive fluoridated direkomendasikan untuk digunakan pada pasien pasca perawatan bleaching.
Proporsi klasifikasi maloklusi angle mahasiswa angkatan 2015 dan 2016 Fakultas Kedokteran Gigi Universitas Padjadjaran
Authors: Khairunnisa Fadila , Zenab N.R. Yuliawati , Latif Deni Sumantri
Published: June 2023

Maloklusi merupakan kondisi oklusi yang menyimpang dari keadaan normal, ditandai dengan ketidaksesuaian hubungan antara gigi-gigi rahang atas dan rahang bawah. Maloklusi dapat dicegah dan diperbaiki melalui perawatan ortodonti. Studi epidemiologi mengenai prevalensi maloklusi merupakan hal penting dalam merencanakan tingkat perawatan ortodonti yang tepat. Metode klasifikasi angle relevan untuk dokter dan mencakup sebagian besar maloklusi yang diamati pada pasien. Angle mengklasifikasikan maloklusi berdasarkan hubungan oklusal molar pertama menjadi tiga kelas, yaitu kelas I, kelas II, dan kelas III. Tujuan penelitian ini adalah untuk mengetahui proporsi klasifikasi maloklusi angle mahasiswa Fakultas Kedokteran Gigi Universitas Padjadjaran. Penelitian observasional deskriptif dengan desain cross-sectional untuk mengetahui proporsi klasifikasi maloklusi angle mahasiswa angkatan 2015 dan 2016 Fakultas Kedokteran Gigi Universitas Padjadjaran dengan memeriksa relasi gigi molar rahang atas dan rahang bawah. Populasi penelitian berjumlah 188 model studi dan didapatkan sampel sebanyak 120 model studi berdasarkan kriteria inklusi dan eksklusi. Hasil penelitian menunjukkan maloklusi kelas I sebanyak 82 sampel (68,33%), kelas II sebanyak 5 sampel (4,17%), kelas II subdivisi sebanyak 17 sampel (14,17%), kelas III sebanyak 9 sampel (7,5%), dan kelas III subdivisi sebanyak 7 sampel (5,83%). Maloklusi kelas I paling banyak terjadi diikuti dengan kelas II subdivisi, kelas III, kelas III subdivisi, dan kelas II pada mahasiswa angkatan 2015 dan 2016 Fakultas Kedokteran Gigi Universitas Padjadjaran.
A SUGGESTION FOR PROACTIVE CARDIOLOGIC APPROACH TO CUSHING’S SYNDROME OR DISEASE
Authors: Koraćević Goran , Zdravković Miloš , Koraćević Maja , Pavlović Dimitrije A. , Damjanović Miodrag , Pavlović Milorad , Dakić Sonja , Cvetković Predrag , Mladenović Katarina , Stojković Milan
Published: June 2023

Numerous studies and reviews agree about the increased cardiovascular risk in Cushing’s syn-drome. Therefore, the aim of the paper is to suggest a few common diagnostic and therapeutic cardiologic preferences for the majority of Cushing’s syndrome/Cushing’s disease (CS/CD) pa-tients which are not yet routine but have the rationale to become standard procedures. This may serve as an initial working document, to be improved by the experts in the field. A narrative review is used to present synthesis and deduction of several approaches in cardiology regarding the actu-al topic. Results are systematized as the risk factors or co-morbidities list (prevalent in CS/CD) coupled with current and adapted cardiologic suggestions for practice.
COULD IT BE BEHÇET'S DISEASE? PHYSICIANS IN PRIMARY HEALTHCARE ARE THE FIRST TO RESPOND
Authors: Knežević Snežana , Vulović Jelena , Jandrić-Kočić Marijana
Published: June 2023

Behçet's disease is a chronic relapsing vasculitis with complex immunopathogenesis that can affect multiple organs, although mucocutaneous lesions are predominantly observed. Diagnosis of Behçet's disease is challenging and relies on clinical manifestations as no specific laboratory test is available. A positive Pathergy test should raise suspicion of Behçet's disease. The authors present a clinical case of a 22-year-old woman who presented with intermittent fever, weight loss, odynophagia, dysphagia, left knee arthritis, and multiple painful oral-genital aphthosis. The patient received treatment with benzydamine hydrochloride mouthwash, lidocaine on ulcers, antibiotics, and non-steroidal anti-inflammatory drugs, but the healing process was slow, and a new disease attack occurred two months later. The Pathergy test was performed and found to be positive, prompting consultation with an immunologist and gynecologist. The patient was administered Colchicine (1.5 mg/day), which resulted in decreased symptoms, albeit with a slow healing process. During the 6-month follow-up period, the disease attack was followed by a period of remission. The evidence base for the treatment of Behçet's disease is limited, and current options include symptomatic, non-biological, and biological immunosuppressive drugs to reduce clinical manifestations. A thorough evaluation and education in primary healthcare settings are crucial to facilitate timely multidisciplinary referrals for effective management of Behçet's disease.