bluuebunny/crossref_metadata_2025 huggingface dataset:
Mucoadhesive Buccal Film of Estradiol for Hormonal Replacement Therapy: Development and In-Vivo Performance Prediction
Authors: Abdella Sadikalmahdi , Afinjuomo Franklin , Song Yunmei , Upton Richard , Garg Sanjay
Published: March 2022

The age-related loss of circulating estrogen that occurs during the menopausal transition manifests itself through a variety of symptoms including vasomotor (hot flushes and night sweats), genito-urinary syndrome (vaginal dryness and urinary symptoms), sexual dysfunction, mood, and sleep disturbance that often last longer than a decade. Furthermore, reductions in estrogen level increase the risks of chronic complications such as osteoporosis, cardiovascular disease, and cognitive decline among others, thereby affecting the quality of life of women. Although oral estrogens are the most widely used therapy for menopausal symptoms, they suffer from poor bioavailability, and there are concerns over their safety, creating a significant concern to consumers. Mucoadhesive buccal films are an innovative dosage form that offers several advantages including avoidance of the first-pass metabolism, fast onset of action, and importantly, improved patient acceptance. In the current work, we developed mucoadhesive estradiol film for hormonal replacement therapy using film-forming polymers. Two approaches, namely, co-solvency and nano-emulsion were evaluated to increase solubility and hence incorporate estradiol, a poorly water-soluble drug, into a formulation made from the hydrophilic polymer/s. The films were characterised for their mechanical and physicochemical properties. In-vitro release study showed that about 80% of the drug was released within 6 min from films prepared by the nano-emulsion approach, whereas it took about 10.5 min to get similar drug release from films prepared by the co-solvency approach. The ex-vivo permeation result indicates that about 15% of the drug permeated across the porcine buccal mucosa in the first 10 h from films prepared by the nano-emulsion approach, while permeation across porcine buccal mucosa was only observed at around 24 h from films prepared by the co-solvency method. The nano-emulsion films were evaluated for in vivo performance using a convolution technique using R software. The predicted Cmax and Tmax were found to be 740.74 ng mL−1 and 7 min, respectively, which were higher than previously reported in vivo concentration from oral tablets. The results demonstrated that mucoadhesive film of estradiol based on the nano-emulsion approach could be a promising platform for the delivery of estradiol through the buccal mucosa for the treatment of menopausal symptoms.
Sparsomycin Exhibits Potent Antiplasmodial Activity In Vitro and In Vivo
Authors: Ariefta Nanang Rudianto , Pagmadulam Baldorj , Nihei Coh-ichi , Nishikawa Yoshifumi
Published: March 2022

The emerging spread of drug-resistant malaria parasites highlights the need for new antimalarial agents. This study evaluated the growth-inhibitory effects of sparsomycin (Sm), a peptidyl transferase inhibitor, against Plasmodium falciparum 3D7 (chloroquine-sensitive strain), P. falciparum K1 (resistant to multiple drugs, including chloroquine), P. yoelii 17XNL (cause of uncomplicated rodent malaria) and P. berghei ANKA (cause of complicated rodent malaria). Using a fluorescence-based assay, we found that Sm exhibited half-maximal inhibitory concentrations (IC50) of 12.07 and 25.43 nM against P. falciparum 3D7 and K1, respectively. In vitro treatment of P. falciparum 3D7 with Sm at 10 or 50 nM induced morphological alteration, blocked parasites in the ring state and prevented erythrocyte reinvasion, even after removal of the compound. In mice infected with P. yoelii 17XNL, the administration of 100 μg/kg Sm for 7 days did not affect parasitemia. Meanwhile, treatment with 300 μg/kg Sm resulted in a significantly lower parasitemia peak (18.85%) than that observed in the control group (40.13%). In mice infected with P. berghei ANKA, both four and seven doses of Sm (300 μg/kg) prolonged survival by 33.33%. Our results indicate that Sm has potential antiplasmodial activities in vitro and in vivo, warranting its further development as an alternative treatment for malaria.
Operating Vector Solitons with Chirped Sech Pulse Shapes
Authors: Zhou Yan , Zhang Keyun , Liao Meisong , Zhao Guoying , Fang Yongzheng
Published: March 2022

In this paper, we report the theoretical results about operating vector solitons with chirped sech pulse shapes. In the operation, the shapes of temporal pulses and corresponding optical spectra in orthogonal directions will change, which are based on soliton parameters. When input orthogonal pulses have the same central wavelength of 1064 nm, the shift from the central wavelength always occurs for orthogonal pulses. When input orthogonal pulses have different central wavelengths of 1063 nm and 1065 nm, output pulse shapes and optical spectra with obvious multiple peak/dip structures can be achieved in orthogonal directions. Our theoretical results are meaningful for the study of vector soliton dynamics and have potential applications in optical communication and optical sensing.
Topological Charge of Multi-Color Optical Vortices
Authors: Kotlyar Victor Victorovich , Kovalev Alexey Andreevich , Nalimov Anton Gennadyevich , Stafeev Sergey Sergeevich
Published: March 2022

The topological charge of an optical vortex is a quantity rather stable against phase distortions, for example, turbulence. This makes the topological charge attractive for optical communications, but for many structured beams it is unknown. Here, we derive the topological charge (TC) of a coaxial superposition of spatially coherent Laguerre–Gaussian beams with different colors, each beam with its own wavelength and its own TC. It turns out that the TC of such a superposition equals the TC of the LG beam with a longer wavelength, regardless of the weight coefficient of this beam in the superposition and regardless of its TC. It is interesting that the instantaneous TC of such a superposition is conserved on propagation, whereas the time-averaged intensity distribution of the colored optical vortex changes its gamut; if, in the near field, the colors of the light rings arrange along the radius according to their TCs in the superposition from lower to greater, then, on space propagation, the colors of the light rings in the cross-section are arranged in reverse order from the greater TC to the lower TC. We also demonstrate that, by choosing appropriate wavelengths (blue, green, and red) in a three-color superposition of single-ringed LG beams, it is possible to generate, at some propagation distance, a time-averaged light ring of the white color. If all the beams in a three-color superposition of single-ringed LG beams have the same TC, then there is a single ring of nearly white light in the initial plane. Then, on propagation in space, light rings of different colors acquire different radii: a smaller ring radius for a shorter wavelength.
Genome-Wide Identification, Characterization and Expression Analysis of Lipoxygenase Gene Family in Artemisia annua L.
Authors: Meng Ying , Liang Yu , Liao Baosheng , He Wenrui , Liu Qianwen , Shen Xiaofeng , Xu Jiang , Chen Shilin
Published: March 2022

Lipoxygenase (LOX) is a ubiquitous oxygenase found in animals and plants and plays a pivotal role in diverse biological processes, including defense and development. Artemisinin, which can only be obtained from Artemisia annua L., is the most effective therapeutic drug for malaria without serious side effects. This study identified and analyzed LOX gene family members in the A. annua genome at the chromosomal level. Twenty LOX genes with various molecular weights, isoelectric points, and amino acid numbers were identified and named AaLOX, which were located in the cytoplasm or chloroplast. The average protein length of all AaLOX was 850 aa. Phylogenetic tree analysis revealed that the AaLOX was divided into two major groups, 9-LOX and 13-LOX. The exon numbers ranged from 1 to 12, indicating that different AaLOX genes have different functions. The secondary structure was mainly composed of alpha helix and random coil, and the tertiary structure was similar for most AaLOX. Upstream promoter region analysis revealed that a large number of cis-acting elements were closely related to plant growth and development, light response, hormone, and other stress responses. Transcriptome data analysis of different tissues suggested that the gene family was differently expressed in the roots, stems, leaves, and flowers of two A. annua strains HAN1 and LQ9. qRT-PCR confirmed that AaLOX5 and AaLOX17 had the highest expression in flowers and leaves. This study provides a theoretical basis for the further functional analysis of the AaLOX gene family.
Agathis robusta Bark Essential Oil Effectiveness against COVID-19: Chemical Composition, In Silico and In Vitro Approaches
Authors: Mohamed Maged E. , Tawfeek Nora , Elbaramawi Samar S. , Fikry Eman
Published: March 2022

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV2), the causative agent of Coronavirus Disease 2019 (COVID-19), has seriously threatened global health. Alongside the approved vaccines, the discovery of prospective anti-COVID-19 drugs has been progressively targeted. Essential oils (EOs) provide a rich source of compounds with valuable antiviral activities that may contribute as effective agents against COVID-19. In this study, the EO of Agathus robusta bark was investigated for its chemical composition and its antiviral activity against SARS-CoV2. Overall, 26 constituents were identified by gas chromatography-mass spectrometry (GC-MS) analysis. α-Pinene, tricyclene, α-terpineol, limonene, d-camphene, trans-pinocarveol, α-phellandren-8-ol, L-β-pinene and borneol were the major components. In silico docking of these constituents against viral key enzymes, spike receptor-binding domain (RBD), main protease (Mpro) and RNA-dependent RNA polymerase (RdRp), using Molecular Operating Environment (MOE) software revealed good binding affinities of the components to the active site of the selected targets, especially, the RBD. In Vitro antiviral MTT and cytopathic effect inhibition assays demonstrated a promising anti SARS-CoV2 for A. robusta bark EO, with a significant selectivity index of 17.5. The results suggested using this EO or its individual components for the protection against or treatment of COVID-19.
Understanding the Relationships between Free Asparagine in Grain and Other Traits to Breed Low-Asparagine Wheat
Authors: Oddy Joseph , Raffan Sarah , Wilkinson Mark D. , Elmore J. Stephen , Halford Nigel G.
Published: March 2022

Since the discovery of acrylamide in food, and the identification of free asparagine as the key determinant of acrylamide concentration in wheat products, our understanding of how grain asparagine content is regulated has improved greatly. However, the targeted reduction in grain asparagine content has not been widely implemented in breeding programmes so far. Here we summarise how free asparagine concentration relates to other quality and agronomic traits and show that these relationships are unlikely to pose major issues for the breeding of low-asparagine wheat. We also outline the strategies that are possible for the breeding of low-asparagine wheat, using both natural and induced variation.
Genetic Analysis for Resistance to Sclerotinia Stem Rot, Yield and Its Component Traits in Indian Mustard [Brassica juncea (L.) Czern & Coss.]
Authors: Singh Manjeet , Avtar Ram , Kumar Neeraj , Punia Rakesh , Pal Ajay , Lakra Nita , Kumari Nisha , Kumar Dalip , Naruka Anu , Bishnoi Mahavir , Khedwal Rajbir Singh , Choudhary Raju Ram , Singh Anoop , Meena Ravindra Kumar , Dhillon Ankit , Singh Vivek K.
Published: March 2022

Understanding the mode of gene action that controls seed yield and Sclerotinia stem rot resistance in Indian mustard is critical for boosting yield potential. In a line × tester mating design, ten susceptible lines and four resistant testers were used to conduct genetic analysis. The significance of general combining ability (GCA) and specific combining ability (SCA) variances revealed that both additive and non-additive gene actions were involved in the inheritance of Sclerotinia stem rot resistance and yield attributing traits. In addition to 1000-seed weight and number of primary and secondary branches/plant, the genotypes RH 1569 (line) and DRMR 2035 (tester) appeared to be the strongest general combiners for Sclerotinia stem rot resistance. RH 1657 × EC 597317 was the only cross among several that demonstrated a significant desired SCA value for Sclerotinia rot resistance. Regarding SCA effects for yield and component traits, the cross RH 1658 × EC 597328 performed best, with a non-significant but acceptable negative SCA effect for resistance. DRMR 2035, RH 1222-28, RH 1569, RH 1599-41, RH 1657, RH 1658, and EC 597328 are promising genotypes to use as parents in future heterosis breeding and for obtaining populations with high yield potential and greater resistance to Sclerotinia stem rot disease in Indian mustard, based on GCA effects of parents, per se performance, and SCA effects of hybrids. Days to 50% flowering, number of primary branches/plant, main shoot length, and 1000-seed weight all had a high genotypic coefficient of variability (GCV), broad-sense heritability (h2bs), and genetic advance as percent of the mean (GAM) values, as well as significant and desirable correlations and direct effects on seed yield. As a result, these traits have been recognized as the most critical selection criterion for Indian mustard breeding programs.
Fluorescence Microscopy Methods for the Analysis and Characterization of Lignin
Authors: Maceda Agustín , Terrazas Teresa
Published: March 2022

Lignin is one of the most studied and analyzed materials due to its importance in cell structure and in lignocellulosic biomass. Because lignin exhibits autofluorescence, methods have been developed that allow it to be analyzed and characterized directly in plant tissue and in samples of lignocellulose fibers. Compared to destructive and costly analytical techniques, fluorescence microscopy presents suitable alternatives for the analysis of lignin autofluorescence. Therefore, this review article analyzes the different methods that exist and that have focused specifically on the study of lignin because with the revised methods, lignin is characterized efficiently and in a short time. The existing qualitative methods are Epifluorescence and Confocal Laser Scanning Microscopy; however, other semi-qualitative methods have been developed that allow fluorescence measurements and to quantify the differences in the structural composition of lignin. The methods are fluorescence lifetime spectroscopy, two-photon microscopy, Föster resonance energy transfer, fluorescence recovery after photobleaching, total internal reflection fluorescence, and stimulated emission depletion. With these methods, it is possible to analyze the transport and polymerization of lignin monomers, distribution of lignin of the syringyl or guaiacyl type in the tissues of various plant species, and changes in the degradation of wood by pulping and biopulping treatments as well as identify the purity of cellulose nanofibers though lignocellulosic biomass.
Enhanced Electromagnetic Interference Shielding Properties of Immiscible Polyblends with Selective Localization of Reduced Graphene Oxide Networks
Authors: Meng Yiming , Sharma Sushant , Chung Jin Suk , Gan Wenjun , Hur Seung Hyun , Choi Won Mook
Published: March 2022

Herein, an effective technique of curing reaction-induced phase separation (CRIPS) was used to construct a reduced graphene oxide (RGO) network in the immiscible diglycidyl ether of the bisphenol A/polyetherimide (DGEBA/PEI) polyblend system. The unique chemical reduction of RGO facilitated the reduction of oxygenated groups and simultaneously appended amino groups that stimulate the curing process. The selective interfacial localization of RGO was predicted numerically by the harmonic and geometric mean technique and further confirmed by field emission transmission electron microscopy (FETEM) analysis. Due to interfacial localization, the electrical conductivity was increased to 366 S/m with 3 wt.% RGO reinforcement. The thermomechanical properties of nanocomposites were determined by dynamic mechanical analysis (DMA). The storage modulus of 3 wt.% RGO-reinforced polyblend exhibited an improvement of ~15%, and glass transition temperature (Tg) was 10.1 °C higher over neat DGEBA. Furthermore, the total shielding effectiveness (SET) was increased to 25.8 dB in the X-band region, with only 3 wt.% RGO, which represents ~99.9% shielding efficiency. These phase separation-controlled nanocomposites with selective localization of electrically conductive nanofiller at a low concentration will extend the applicability of polyblends to multifunctional structural nanocomposite applications.
Polyurea Aerogels: Synthesis, Material Properties, and Applications
Authors: Leventis Nicholas
Published: March 2022

Polyurea is an isocyanate derivative, and comprises the basis for a well-established class of polymeric aerogels. Polyurea aerogels are prepared either via reaction of multifunctional isocyanates with multifunctional amines, via reaction of multifunctional isocyanates and water, or via reaction of multifunctional isocyanates and mineral acids. The first method is the established one for the synthesis of polyurea, the third is a relatively new method that yields polyurea doped with metal oxides in one step, while the reaction of isocyanates with water has become the most popular route to polyurea aerogels. The intense interest in polyurea aerogels can be attributed in part to the low cost of the starting materials—especially via the water method—in part to the extremely broad array of nanostructural morphologies that allow study of the nanostructure of gels as a function of synthetic conditions, and in part to the broad array of functional properties that can be achieved even within a single chemical composition by simply adjusting the synthetic parameters. In addition, polyurea aerogels based on aromatic isocyanates are typically carbonizable materials, making them highly competitive alternatives to phenolic aerogels as precursors of carbon aerogels. Several types of polyurea aerogels are already at different stages of commercialization. This article is a comprehensive review of all polyurea-based aerogels, including polyurea-crosslinked oxide and biopolymer aerogels, from a fundamental nanostructure–material properties perspective, as well as from an application perspective in thermal and acoustic insulation, oil adsorption, ballistic protection, and environmental cleanup.
Unscented Kalman Filter-Based Robust State and Parameter Estimation for Free Radical Polymerization of Styrene with Variable Parameters
Authors: Zhang Zhenhui , Zhang Zhengjiang , Hong Zhihui
Published: March 2022

The free radical polymerization of styrene (FRPS) is a complex process system with uncertain parameters in its mechanistic model. When the reaction conditions are switched, or the reaction process generates faults, the parameters will change. Therefore, state and parameter estimation (SPE) becomes an important part of the process monitoring and process control for free radical polymerization of styrene. The unscented Kalman filter (UKF) is widely used for nonlinear process systems, but it rarely considers the problem of model parameter uncertainty. UKF can be used for SPE, called UKF-based SPE (UKF-SPE), where the parameters are usually estimated simultaneously as an extension of the state space. However, when the parameters change with system switching, the traditional UKF-SPE cannot detect and track the parameter changes in time, and inaccurate parameters generate modeling errors. To deal with the problem, a UKF-based robust SPE method (UKF-RSPE) for the free radical polymerization of styrene with variable parameters is proposed, introducing a parameter testing criterion based on hypothesis testing and moving windows to directly detect whether the parameters have changed. Based on the detection results, a gradient descent method with adaptive learning rate is used to iteratively update the parameters to speed up the tracking of the parameters and to obtain more accurate parameters and states. Finally, the proposed UKF-based robust SPE is applied to free radical polymerization of styrene in a jacketed continuous stirred tank reactor. The experimental results verify the effectiveness and robustness of the method, which can track the parameters faster and obtain more accurate states.
High Performance Polymer Composites: A Role of Transfer Films in Ensuring Tribological Properties—A Review
Authors: Panin Sergey V. , Alexenko Vladislav O. , Buslovich Dmitry G.
Published: March 2022

The purpose of this review is to summarize data on the structure, mechanical and tribological properties, and wear patterns of composites based on high-performance polymers (HPPs) intended for use in friction units. The review includes three key sections, divided according to the tribological contact schemes regardless of the polymer matrix. In the second part, the analysis of composites is carried out in point contacts. The third section is devoted to the results of studies of HPP-based composites in linear ones. The fourth section summarizes information on flat contacts. Particular attention is paid to the formation of transfer films (TFs) in the contacts and their influence on the tribological patterns of the studied rubbing materials. As a conclusion, it is noted that the challenge of experimental methods for analyzing TFs, stated by K. Friedrich, is effectively solved in recent studies by the XPS method, which enables us to accurately determine their composition. Although this determination is completed after the tribological tests, it allows not only a more accurate interpretation of their results considering specific conditions and loading schemes, but also the ability to design HPP-based composites that form required TFs performing their preset functions.
Advances of Hydroxyapatite Hybrid Organic Composite Used as Drug or Protein Carriers for Biomedical Applications: A Review
Authors: Huang Ssu-Meng , Liu Shih-Ming , Ko Chia-Ling , Chen Wen-Cheng
Published: March 2022

Hydroxyapatite (HA), especially in the form of HA nanoparticles (HANPs), has excellent bioactivity, biodegradability, and osteoconductivity and therefore has been widely used as a template or additives for drug delivery in clinical applications, such as dentistry and orthopedic repair. Due to the atomically anisotropic distribution on the preferred growth of HA crystals, especially the nanoscale rod-/whisker-like morphology, HA can generally be a good candidate for carrying a variety of substances. HA is biocompatible and suitable for medical applications, but most drugs carried by HANPs have an initial burst release. In the adsorption mechanism of HA as a carrier, specific surface area, pore size, and porosity are important factors that mainly affect the adsorption and release amounts. At present, many studies have developed HA as a drug carrier with targeted effect, porous structure, and high porosity. This review mainly discusses the influence of HA structures as a carrier on the adsorption and release of active molecules. It then focuses on the benefits and effects of different types of polymer-HA composites to re-examine the proteins/drugs carry and release behavior and related potential clinical applications. This literature survey can be divided into three main parts: 1. interaction and adsorption mechanism of HA and drugs; 2. advantages and application fields of HA/organic composites; 3. loading and drug release behavior of multifunctional HA composites in different environments. This work also presents the latest development and future prospects of HA as a drug carrier.
Improvement of the PLA Crystallinity and Heat Distortion Temperature Optimizing the Content of Nucleating Agents and the Injection Molding Cycle Time
Authors: Aliotta Laura , Sciara Letizia Maria , Cinelli Patrizia , Canesi Ilaria , Lazzeri Andrea
Published: March 2022

Three different commercial nucleating agents (LAK, talc, and calcium carbonate) were added at different weight percentages into poly (lactic acid) (PLA) in order to investigate the mechanical and thermo-mechanical behavior of blends in correlation to injection molding parameters. After as-sessing the best content of each nucleating agent, analyzing isothermal and non-isothermal crys-tallization, two cycle times that can be industrially adopted were selected. Crystallinity highly impacts the flexural modulus, while it improves the heat deflection temperature only when the crystallinity percentage is above 50%; nevertheless, an excessive crystallinity content leads to a decrement of impact resistance. LAK does not appear to be sensitive to cycle time while talc and calcium carbonate proved to be effective if a cycle time of 60 s is adopted. Since the choice of nu-cleating agent is not univocal, the identification of the best nucleating agents is subject to the technical specifications required by the application, accotuing for the most important commercial requirements (productivity, temperature, and impact resistance).
Heterogeneous Dendrimer-Based Catalysts
Authors: Karakhanov Eduard , Maximov Anton , Zolotukhina Anna
Published: March 2022

The present review compiles the advances in the dendritic catalysis within the last two decades, in particular concerning heterogeneous dendrimer-based catalysts and their and application in various processes, such as hydrogenation, oxidation, cross-coupling reactions, etc. There are considered three main approaches to the synthesis of immobilized heterogeneous dendrimer-based catalysts: (1) impregnation/adsorption on silica or carbon carriers; (2) dendrimer covalent grafting to various supports (silica, polystyrene, carbon nanotubes, porous aromatic frameworks, etc.), which may be performed in a divergent (as a gradual dendron growth on the support) or convergent way (as a grafting of whole dendrimer to the support); and (3) dendrimer cross-linking, using transition metal ions (resulting in coordination polymer networks) or bifunctional organic linkers, whose size, polarity, and rigidity define the properties of the resulted material. Additionally, magnetically separable dendritic catalysts, which can be synthesized using the three above-mentioned approaches, are also considered. Dendritic catalysts, synthesized in such ways, can be stored as powders and be easily separated from the reaction medium by filtration/centrifugation as traditional heterogeneous catalysts, maintaining efficiency as for homogeneous dendritic catalysts.
Interdependencies between Dynamic Response and Crack Growth in a 3D-Printed Acrylonitrile Butadiene Styrene (ABS) Cantilever Beam under Thermo-Mechanical Loads
Authors: He Feiyang , Khan Muhammad , Aldosari Salem
Published: March 2022

Acrylonitrile butadiene styrene (ABS) is the most commonly used thermoplastic printing material for fused deposition modelling (FDM). FDM ABS can be used in a variety of complex working environments. Notably, the thermo-mechanical coupled loads under complex operating conditions may lead to cracking and ultimately catastrophic structural failure. Therefore, it is crucial to determine the crack depth and location before a structural fracture occurs. As these parameters affect the dynamic response of the structure, in this study, the fundamental frequency and displacement amplitude response of a cracked 3D-printed ABS cantilever beam in a thermal environment were analytically and experimentally investigated. The existing analytical model, specifically the torsional spring model used to calculate the fundamental frequency change to determine the crack depth and location was enhanced by the proposed Khan-He model. The analytical relationship between the displacement amplitude and crack was established in Khan-He model and validated for the first time for FDM ABS. The results show that a reduced crack depth and location farther from the fixed end correspond to a higher fundamental frequency and displacement amplitude. An elevated ambient temperature decreases the global elastic modulus of the cracked beam and results in a lower fundamental frequency. Moreover, a non-monotonic relationship exists between the displacement amplitude and ambient temperature. The displacement amplitude is more sensitive to the crack change than the fundamental frequency in the initial stages of crack growth.
Biopolymer: A Sustainable Material for Food and Medical Applications
Authors: Baranwal Jaya , Barse Brajesh , Fais Antonella , Delogu Giovanna Lucia , Kumar Amit
Published: March 2022

Biopolymers are a leading class of functional material suitable for high-value applications and are of great interest to researchers and professionals across various disciplines. Interdisciplinary research is important to understand the basic and applied aspects of biopolymers to address several complex problems associated with good health and well-being. To reduce the environmental impact and dependence on fossil fuels, a lot of effort has gone into replacing synthetic polymers with biodegradable materials, especially those derived from natural resources. In this regard, many types of natural or biopolymers have been developed to meet the needs of ever-expanding applications. These biopolymers are currently used in food applications and are expanding their use in the pharmaceutical and medical industries due to their unique properties. This review focuses on the various uses of biopolymers in the food and medical industry and provides a future outlook for the biopolymer industry.
On-Demand Tailoring between Brittle and Ductile of Poly(methyl methacrylate) (PMMA) via High Temperature Stretching
Authors: Wang Changchun , Pek Jia Xi , Chen Hong Mei , Huang Wei Min
Published: March 2022

Dog-bone shaped poly(methyl methacrylate) (PMMA) samples were pre-stretched at different temperatures (within the glass transition range and slightly above) to different strains. Subsequently, these pre-stretched samples were aged at 40 °C for up to three months, and finally, all samples were uniaxially stretched to fracture. The Young’s modulus, ultimate stress and toughness of the samples were obtained and plotted as a function of the temperature, and strain in pre-stretching in the contour format. The influence of aging was revealed when the contours of different aging times were compared. One of the most interesting findings was that the toughness of this PMMA can be tailored via controlling the temperature and strain in pre-stretching. The toughness of the pre-stretched samples ranged from 1.317 MJ/m3 to 23.281 MJ/m3 (without aging) and from 1.476 MJ/m3 to 27.532 MJ/m3 (after three months of aging). Based on the results of a series of additional experiments, a mechanism was proposed to reveal the fundaments behind the influence of the temperature and strain in pre-stretching and aging.
Macroscopic Stress-Strain Response and Strain-Localization Behavior of Biopolymer-Treated Soil
Authors: Soldo Antonio , Aguilar Victor , Miletić Marta
Published: March 2022

The enhancement of soil engineering properties with biopolymers has been shown recently as a viable and environmentally benign alternative to cement and chemical stabilization. Interest in biopolymer-treated soil is evident from the upsurge of related research activities in the last five years, most of which have been experimental in nature. However, biopolymers have not yet found their way into engineering practice. One of the reasons for this may be the absence of computational models that would allow engineers to incorporate biopolymer-treated soil into their designs. Therefore, the main goal of this study is to numerically capture a macroscopic stress-strain response and investigate the effect of biopolymers on the onset of strain localization. Several diagnostic strain-localization analyses were conducted, thus providing strain and stress levels at the onset of strain localization, along with the orientations of the deformation band. Several unconfined compression and triaxial tests on the plain and biopolymer-treated soils were modeled. Results showed that biopolymers significantly improved the mechanical behavior of the soil and affected the onset of strain localization. The numerical results were confirmed by the digital image analysis of the unconfined compression tests. Digital image processing successfully captured high strain concentrations, which tended to occur close to the peak stress.
Effects of Functionalized Kraft Lignin Incorporation on Polypropylene Surface Energy and Practical Adhesion
Authors: Bisneto Manuel Patricio da Silva , Gouveia Julia Rocha , Antonino Leonardo Dalseno , Tavares Lara Basílio , Ito Nathalie Minako , dos Santos Demetrio Jackson
Published: March 2022

Polypropylene (PP) is a multifunctional and widely applied polymer. Nevertheless, its low energy surface and poor adhesion are well-known and might impair some prospective applications. Aiming to overcome these limitations, PP composites can be applied as a tool to enhance PP surface energy and then increase its practical adhesion. In this work, Kraft lignin (KL) was chemically modified and blended with PP. In short, KL was hydroxypropylated and further reacted with acetic anhydride (A-oxi-KL) or maleic anhydride (M-oxi-KL). Lignin modifications were confirmed by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA). PP-composites with different lignin contents, as well as pristine PP, were characterized in terms of their thermal behavior, morphology, surface energy, and practical adhesion by DSC, scanning electron microscopy (SEM), contact angle measurement, and peeling tests, respectively. Lignin incorporation did not affect the PP degree of crystallization. The lignin modifications led to a better compatibility with the PP matrix and surface energies up to 86% higher than neat PP. Increases of up to 66% in the peel strength were verified. Composites with M-oxi-KL showed the best adhesion performance, confirming the lignin functionalization is an efficient approach to improve the practical adhesion of PP films.
A Comparison of the Performances of Unmanned-Aerial-Vehicle (UAV) and Terrestrial Laser Scanning for Forest Plot Canopy Cover Estimation in Pinus massoniana Forests
Authors: Dai Wenxia , Guan Qingfeng , Cai Shangshu , Liu Rundong , Chen Ruibo , Liu Qing , Chen Chao , Dong Zhen
Published: March 2022

Canopy cover is an important indicator and commonly used in forest management applications. Unmanned-Aerial-Vehicle (UAV)—Borne Laser Scanning (ULS) has drawn increasing attention as a new alternative source for forest field inventory due to its spatial resolution comparable to that of Terrestrial Laser Scanning (TLS). In this study, the performance of plot canopy cover estimations from ULS and TLS is investigated. The experiment was conducted in 16 plots from two Pinus massoniana forests with different stand conditions in Guangxi, China. Both the Canopy Height Model (CHM)-based and Individual Tree Delineation (ITD)-based methods were used to estimate the canopy cover. The influence of CHM pixel sizes on the estimations was also analyzed. Our results demonstrated that the accuracies of ULS (R2: 0.992–0.996, RMSE: 0.591–0.820%) were better than those of TLS (R2: 0.541–0.846, RMSE: 3.642–6.297%) when compared against the reference. The average difference between the ULS and TLS estimations was 6.91%, and the disagreement increased as the forest complexity increased. The reasonable CHM pixel sizes for the canopy cover estimations were 0.07–1.2 m for ULS and 0.07–1.5 m for TLS. This study can provide useful information for the selection of data sources and estimation methods in plot canopy cover mapping.
Characteristics of Regions with High-Density Initiation of Flashes in Mesoscale Convective Systems
Authors: Wang Fei , Zhang Yijun , Deng Xiaohua , Liu Hengyi , Dong Wansheng , Yao Wen
Published: March 2022

To investigate the characteristics of regions exhibiting multiple lightning initiations within a finite volume and a short time, the lightning location data obtained from the convective regions of 14 mesoscale convective systems were analyzed in combination with data from radar. In total, 415 out of 5996 radar grids (1 km × 1 km × 0.5 km) were found to initiate more than one flash within 6 min. Only 49 grids showed an initiation density of more than two flashes within 6 min. The grids with high flash initiation densities were found to have a similar distribution to those with one lightning initiation within 6 min, in terms of altitude and reflectivity relative to altitude. They also showed similar trends in their frequency evolution. The grids with higher initiation densities seemed to be more concentrated in the altitude range of 9–13 km. However, only one was found to form at a lower altitude near the melting level when lightning initiation clearly declined. Moreover, the spatial relationship of this lower higher-initiation density grid to the reflectivity core was different to that in the main altitude range. In this paper, the possible dynamic and electrical mechanisms of the formation of this lower higher-initiation density grid are discussed.
Linear Regression vs. Deep Learning: A Simple Yet Effective Baseline for Human Body Measurement
Authors: Bartol Kristijan , Bojanić David , Petković Tomislav , Peharec Stanislav , Pribanić Tomislav
Published: March 2022

We propose a linear regression model for the estimation of human body measurements. The input to the model only consists of the information that a person can self-estimate, such as height and weight. We evaluate our model against the state-of-the-art approaches for body measurement from point clouds and images, demonstrate the comparable performance with the best methods, and even outperform several deep learning models on public datasets. The simplicity of the proposed regression model makes it perfectly suitable as a baseline in addition to the convenience for applications such as the virtual try-on. To improve the repeatability of the results of our baseline and the competing methods, we provide guidelines toward standardized body measurement estimation.
Vaccine Nationalism or ‘Brexit Dividend’? Strategies of Legitimation in the EU-UK Post-Brexit Debate on COVID-19 Vaccination Campaigns
Authors: Caliendo Giuditta
Published: March 2022

The initial stage of the COVID-19 vaccine rollout has been slow-moving and marred by supply disruptions in the EU. These problems have triggered severe criticism toward the institutions and highlighted a stark contrast compared to Britain’s vaccination campaign, which, at the beginning of 2021, was one of the fastest in the continent. In the ensuing debate between the EU and the UK on their uneven vaccination rates, the Brexit argument has been repeatedly invoked: Some political commentators have argued that the reason why COVID-19 vaccination campaign could run so smoothly in Britain is that the country was not held back by the EU’s slow approval process. This paper observes the way in which Britain emphasized its blistering vaccination pace to deflect criticism against Brexit. From a discursive perspective, Britain’s vaccine success was used to vindicate the Brexit project, providing a new argument in favour of its indispensable and timely nature. At the other end of a binary rhetoric, the EU officials attempted to shatter confidence in the ‘British vaccine’, while also depositing blame on other factors triggering the EU’s delay, such as the shortage of pharmaceutical supplies. The analytical part of this paper foregrounds strategies of discursive legitimation to observe how, and to what extent, the Brexit debate is being reshaped in UK and EU media by looking at a corpus of political tweets. The rhetorical strategies adopted by UK political leaders and EU officials to (de)legitimise national and supranational choices with reference to the COVID-19 vaccination campaign are observed through the lens of Critical Discourse Analysis as it embraces the idea that discursive acts are in dialectical relation to the social and institutional structures in which they are framed.
Memories of Steven Weinberg (1933–2021)
Authors: Frampton Paul H.
Published: March 2022

Steven Weinberg, renowned particle theorist and Nobel laureate, passed away in July 2021. We discuss selections of his work on effective field theory, electroweak unification, and symmetry related topics. We then add a few memories of Weinberg at Harvard University then at the University of Texas, Austin.
Genetic Factors That Affect Asymmetric Mandibular Growth—A Systematic Review
Authors: Babczyńska Alicja , Kawala Beata , Sarul Michał
Published: March 2022

Facial asymmetry is a feature that occurs to a greater or lesser extent in the general population. As its severity is usually slight, facial asymmetry may not be noticeable to the patient. However, there are cases when severe facial asymmetry not only affects the facial aesthetics by distorting facial proportions, but also contributes to problems related to the function of the stomatognathic system. The nodal signalling pathway appears to be of particular importance in the process of mandibular asymmetry, as it affects not only structures formed from the first pharyngeal arch, but also other organs, such as the heart and lungs. Following the evaluation of the available literature, the inheritance of mandibular asymmetry is a very complex and multifactorial process, and the genes whose altered expression appears to be a more important potential aetiological factor for asymmetry include PITX2, ACTN3, ENPP1 and ESR1. This systematic review attempts to systematise the available literature concerning the impact of signalling pathway disruption, including the disruption of the nodal signalling pathway, on the development of mandibular asymmetry.
A Novel Compound-Coupled Hyperchaotic Map for Image Encryption
Authors: Etoundi Christophe Magloire Lessouga , Nkapkop Jean De Dieu , Tsafack Nestor , Ngono Joseph Mvogo , Ele Pierre , Wozniak Marcin , Shafi Jana , Ijaz Muhammad Fazal
Published: March 2022

Considering a nonlinear dynamic oscillator, a high Lyapunov exponent indicates a high degree of randomness useful in many applications, including cryptography. Most existing oscillators yield very low Lyapunov exponents. The proposed work presents a general strategy to derive an n-D hyperchaotic map with a high Lyapunov exponent. A 2D case study was analyzed using some well-known nonlinear dynamic metrics including phase portraits, bifurcation diagrams, finite time Lyapunov exponents, and dimension. These metrics indicated that the state of the novel map was more scattered in the phase plane than in the case of some traditional maps. Consequently, the novel map could produce output sequences with a high degree of randomness. Another important observation was that the first and second Lyapunov exponents of the proposed 2D map were both positive for the whole parameter space. Consequently, the attractors of the map could be classified as hyperchaotic attractors. Finally, these hyperchaotic sequences were exploited for image encryption/decryption. Various validation metrics were exploited to illustrate the security of the presented methodology against cryptanalysts. Comparative analysis indicated the superiority of the proposed encryption/decryption protocol over some recent state-of-the-art methods.
Host-Species Variation and Environment Influence Endophyte Symbiosis and Mycotoxin Levels in Chinese Oxytropis Species
Authors: Guo Chenchen , Zhang Li , Zhao Qianqian , Beckmann Manfred , Phillips Helen , Meng Huizhen , Mo Chonghui , Mur Luis A. J. , He Wei
Published: March 2022

Oxytropis plants are widely distributed in the grasslands in northern China. Some Oxytropis species have been reported to contain the mycotoxin swainsonine, an alkaloid which causes poisoning in livestock, referred to as locoism. Previous studies showed that endophytic fungi (Alternaria oxytropis) symbiotically associate with these Oxytropis species to produce swainsonine. However, the influence of variation within the Oxytropis genus on the fixation or loss of symbiosis and toxicity is poorly understood, as is the influence of environmental factors. Here we used a collection of 17 common Oxytropis species sampled in northern China to assess genetic diversity using genotyping by sequencing which was compared with the levels of the endophyte and swainsonine. Results showed that nine Oxytropis species have detectable A. oxytropis colonisation, and seven Oxytropis species contain sufficient swainsonine to be considered poisonous, whereas the rest may be non-toxic. Species variation rather than the genetic lineage was associated with the fixation or loss of endophyte and swainsonine production, which appears to have resulted from genetic drift. Genotype × Environment (G × E) effects were also found to influence endophyte and swainsonine levels amongst species of the Oxytropis genus. Our study will provide a better understanding about the evolutionary basis of A. oxytropis symbiosis and swainsonine biosynthesis in locoweeds.
Compact Objects in Alternative Gravities
Authors: Blázquez-Salcedo Jose Luis , Kleihaus Burkhard , Kunz Jutta
Published: March 2022

We address neutron stars and black holes in alternative gravities, after recalling their basic properties in General Relativity. Among the plethora of interesting alternative gravities we here focus on an interesting set of scalar-tensor theories. We discuss the phenomenon of spontaneous scalarization, that is, matter induced for neutron stars and curvature induced for black holes. Along with other relevant physical properties, we address the quasi-normal modes of these compact objects. In particular, we consider universal relations of neutron stars to largely reduce the dependence on the equation of state, and we briefly address the shadow of black holes.
The Achievements of the RockStar Group (Perugia) on Astrophysical Modelling and Pallasite Geochemistry
Authors: Ricci Lisa , Petrelli Maurizio , Frondini Francesco , Zucchini Azzurra , Comodi Paola , Bisciotti Andrea , Vescovi Diego , Trippella Oscar
Published: March 2022

In the present work we summarize the first achievements of the RockStar Group of the Department of Physics and Geology (at the University of Perugia, Italy), which is made of a strict collaboration between Physicists and Geologists on astrophysical and planetological studies. The RockStar Group acts on two research lines: (i) astrophysical modeling and (ii) mineralogical and geochemical studies of meteorites. In the first part of the article we review the recent results concerning the development of theoretical modeling of nucleosynthesis and mixing process in asymptotic giant branch. In the second part we report (1) the catalog of the Meteorite collection of University of Perugia and (2) major and trace elements mapping, performed through EPMA and LA-ICP-MS, of the Mineo pallasite, a unique sample hosted by the collection. The new data constrain the Mineo meteorite among the Main Group Pallasites and support the hypothesis of the “early giant impact” formation.