bluuebunny/crossref_metadata_2025 huggingface dataset:
Navigation Techniques in Endoscopic Spine Surgery
Authors: Hagan Matthew J. , Remacle Thibault , Leary Owen P. , Feler Joshua , Shaaya Elias , Ali Rohaid , Zheng Bryan , Bajaj Ankush , Traupe Erik , Kraus Michael , Zhou Yue , Fridley Jared S. , Lewandrowski Kai-Uwe , Telfeian Albert E.
Published: August 2022

Endoscopic spine surgery (ESS) advances the principles of minimally invasive surgery, including minor collateral tissue damage, reduced blood loss, and faster recovery times. ESS allows for direct access to the spine through small incisions and direct visualization of spinal pathology via an endoscope. While this technique has many applications, there is a steep learning curve when adopting ESS into a surgeon’s practice. Two types of navigation, optical and electromagnetic, may allow for widespread utilization of ESS by engendering improved orientation to surgical anatomy and reduced complication rates. The present review discusses these two available navigation technologies and their application in endoscopic procedures by providing case examples. Furthermore, we report on the future directions of navigation within the discipline of ESS.
Measuring Zero-Waste City Performance of a Coal Resource-Based Area in China with MCDM Approach
Authors: Zhao Wenjun , Yang Dandan , Duan Yonghui
Published: August 2022

The zero-waste city is one of the most visionary initiatives for solving waste problems by enhancing the life cycle solid waste management system. However, the development level of ZW city construction remains unclear. Resource-based areas tend to produce large amounts of industrial solid waste, and achieving a zero-waste city is difficult due to insufficient resource utilization capacity. This study proposed a practical integrated MCDM approach to assess the performance of the ZW city and applied the approach to a typical coal resource-based province in China. The spatiotemporal characteristics and factors influencing the performance of zero-waste cities in each city were further explored. The performance levels increased during the study period; however, the growth rate of most cities is slow. Spatially, the performance levels of zero-waste cities gradually decreased from south to north, showing a radiation pattern with Taiyuan at its core. Challenges toward zero-waste city development were further identified, including heavy industrial structure, widespread underutilization of industrial solid waste, inadequate management of hazardous solid waste, low rate of urban domestic waste classification, and ineffective treatment. The approach gives a holistic and broader picture of the zero-waste management performance, which enables us to identify the challenges in promoting zero-waste cities.
Finite-Time Control of Dynamic Positioning Vessel Based on Disturbance Observer
Authors: Xia Guoqing , Zhang Benwei
Published: August 2022

In this paper, a finite-time controller is proposed for dynamic positioning vessels with error constraints and prescribed performance. A nonlinear observer is employed to give the estimations of the unknown disturbances containing an uncertain model, and the estimation errors converge to the equilibrium point in a finite time. A finite-time controller is developed based on the nonlinear observer. Finally, the effectiveness of the proposed control strategies is demonstrated by simulation.
Rendered Image Superresolution Reconstruction with Multichannel Feature Network
Authors: Ren Zhipeng , Zhao Jianping , Chen Chunyi , Lou Yan , Ma Xiaocong , Tao Pengyu
Published: August 2022

In the process of film and television production, clear images can give the audience a real sensory experience, but high-resolution images require a massive amount of production time and highly specialized imaging equipment, which is not a cost-effective solution at the moment. To achieve a better cost efficiency during video production, we propose a multichannel featured superresolution network model that utilizes rendered low-resolution images according to their characteristics. This model includes a feature extraction layer, a series of subnetworks, and a reconstruction module. Inside the network model, a series of subnetworks are cascaded to improve the information flow from coarse to fine, which helps to fully extract the depth, normal vector, edge, and texture features from low-resolution rendered images to reconstruct the high-resolution image. Additionally, residual learning is introduced at each stage to further improve the reconstruction performance. We experiment with the model on the classic Disney Monte Carlo datasets and compare it with several related algorithms. The results show that our algorithm is able to reconstruct the image with clearer details and texture. Thus, our research not only helps to maintain the audience’s sensory experience but also increases the efficiency of film and television production, which also brings considerable economic benefits.
Signal Alteration of the Inner Ear on High-Resolution Three-Dimensional Constructive Interference in Steady State Sequence in Patients with Ménière’s Disease and Labyrinthitis
Authors: Hakim Arsany , Hool Sara-Lynn , Yassa Nabil , Breiding Philipe Sebastian , Pastore-Wapp Manuela , Caversaccio Marco , Anschuetz Lukas , Wagner Franca
Published: August 2022

Introduction: The aim of this study is to evaluate signal alteration in the inner ear using three-dimensional (3D)-constructive interference in steady state (CISS) sequence in patients with Ménière’s disease and labyrinthitis and its correlation with clinical and audiological parameters. Methods: The medical records of the department of otorhinolaryngology were searched for patients with Ménière’s disease or labyrinthitis who underwent MRI with 3D-CISS sequence. Blinded analysis of these patients and of MRI from control subjects without middle or inner ear symptoms was performed to detect any signal asymmetry of the inner ear structures. The results were correlated with clinical symptoms and results of audiological and vestibular tests. Results: Fifty-eight patients with definite Ménière’s disease and 5 patients with labyrinthitis as well as 41 control exams were included. A separate analysis was performed for patients with probable Ménière’s disease (n = 68). A total of 172 3D-CISS sequences were analyzed by 2 blinded independent neuroradiologists. A CISS-hypointense signal of the inner ear structures was found in 3 patients with definite Ménière’s disease (5.2%), in 4 patients with probable Ménière’s disease (5.9%), and 2 patients with labyrinthitis (40%). No CISS hypointensity was found in the control group. Although no significant difference in symptoms or audiological test results was found between patients with and without this signal change, the side of hypointensity was frequently correlated with the symptomatic side and with hearing impairment. Discussion/Conclusion: CISS hypointensity of the inner ear structures was evident in patients with clinical conditions other than vestibular schwannoma – more frequently in labyrinthitis than in Ménière’s disease. This signal alteration was frequently encountered on the same symptomatic side as that of the pathological audiology tests, but it is not a predictor for hearing or vestibular impairment.
Extracorporeal Carbon Dioxide Removal in Patients with Acute Respiratory Distress Syndrome or Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis
Authors: Zhu Yu , Zhen Weifeng , Zhang Xiaoning , Shi Zhenhua , Zhang Ling , Zhou Jiuju , Meng Xiangzhong
Published: August 2022

Background: Extracorporeal carbon dioxide removal (ECCO2R) was used to prevent invasive mechanical ventilation and associated mechanical damage in patients with acute respiratory distress syndrome (ARDS). Objectives: This study aimed to investigate the efficacy and safety of ECCO2R treatment in patients with ARDS or chronic obstructive pulmonary disease (COPD). Methods: MEDLINE, EMBASE, and the Cochrane Library were systematically searched for relevant studies that reported patient prognosis, blood gas parameters, and ECCO2R-related adverse events (AEs) published as of September 2020. Odds ratios (ORs), weighted mean differences (WMDs), and their corresponding 95% confidence intervals (CIs) were used to compare the outcomes. Results: Fifteen studies involving 532 ARDS or COPD patients were included. Compared with controls, ECCO2R did not influence the 28-day mortality (OR = 0.73, 95% CI: 0.28–1.87, p = 0.51), the length of hospital stay (WMD = 3.34, 95% CI: −5.22 to 11.90, p = 0.444), and the length of intensive care unit stay (WMD = −0.39, 95% CI: −8.76 to 7.99, p = 0.928). Compared with baseline values, partial pressure of carbon dioxide (PaCO2) in the ECCO2R group was significantly reduced, while the ratio of arterial oxygen partial pressure to fractional inspired oxygen (PaO2/FiO2) and pH increased. The overall rate of ECCO2R-related AEs was 35% (95% CI: 17–53%, p < 0.001), and bleeding was the most common AE with a rate of 22% (95% CI: 13–31%, p = 0.002). The rate of ECCO2R-related deaths was low. Conclusions: In conclusion, there was no statistically significant difference in the prognosis of patients with and without ECCO2R treatment. ECCO2R significantly reduced PaCO2 and improved PaO2/FiO2 and pH values in patients with ARDS or COPD. Bleeding was the most common ECCO2R-related AE.
The Proportion of Memory CD8+ T Cell Predicts Infection Event in Patients with Peritoneal Dialysis
Authors: Jiao Xiaoyan , Cao Xuesen , Zou Jianzhou , Ji Jun , Ding Xiaoqiang , Yu Xiaofang
Published: August 2022

Introduction: The immune senescence marked by the inflation of memory T cell is established in end-stage renal disease (ESRD) patients with peritoneal dialysis (PD). These patients suffer high incidence of infectious disease, which has been relevant to immune dysfunction. However the association of immune senescence with infection in PD patients is not clear. This prospective study aimed to investigate the relationship between proportion of T cell subsets and infection event in patients on PD. Methods: We enrolled patients on PD >6 months from January 1, 2016 to December 30, 2016 and followed them until April 30, 2020. Baseline T cell subsets from blood were collected at the time of recruitment. The primary end point was infection event including peritonitis, exit site infection, pneumonia, urinary tract infection, and other infection. Results: There were 94 patients (46 male) with a mean age of 56.1 ± 14.9 years old enrolled during the follow-up period, and 26 patients suffered infection events. A higher proportion of effector memory (EM) CD8+ T cells was found in patients with infection than in those without infection. There was no difference in the distribution of EM CD8+ T cells between PD-related and non-dialysis infection. Increased level of EM CD8+ T cells was risk factor for first infection event in PD patients. Conclusion: High level of EM CD8+ T cells could be a significant predictor of infection event in patients on PD.
Suggestive Evidence for an Antidepressant Effect of Metreleptin Treatment in Patients with Lipodystrophy
Authors: Vieira Diana Branco , Antel Jochen , Peters Triinu , Miehle Konstanze , Stumvoll Michael , Hebebrand Johannes , Schlögl Haiko
Published: August 2022

Introduction: Lipodystrophy (LD) syndromes are rare heterogeneous disorders characterized by reduction or absence of subcutaneous fat, low or nondetectable leptin concentrations in blood and impaired hunger/satiety regulation. Metreleptin treatment reverses metabolic complications and improves eating behavior in LD. Because depression in anorexia nervosa (AN), which is also characterized by hypoleptinemia, improves substantially upon treatment with metreleptin, we hypothesized that metreleptin substitution may be associated with an antidepressant effect in patients with LD, too. Methods: In this ancillary study, 10 adult patients with LD were treated with metreleptin. To assess depressive symptoms, the self-rating questionnaire Beck’s Depression Inventory (BDI) was filled in at preestablished time points prior (T1) and after initiation of metreleptin (T2: 1 week; T3: 4 weeks; T4: 12 weeks) dosing. The differences between time points were tested with nonparametric Friedman’s analysis of variance. Sensitivity analyses were performed upon exclusion of the BDI items addressing appetite and weight changes. Results: According to their BDI scores, 4 patients had mild depression and 2 had moderate depression at baseline. Friedman’s test revealed significant differences in BDI scores between the four time points. Post hoc analyses revealed that the difference between T1 and T3 was significant upon Bonferroni correction (p = 0.034, effect size r = 0.88). The sensitivity analyses upon exclusion of the appetite and weight change items again revealed a significant Friedman’s test and significant Bonferroni corrected differences in the revised BDI scores between T1 versus T2 (p = 0.002, r = 0.99) and T1 versus T3 (p = 0.007, r = 0.79). Discussion/Conclusion: Our study for the first time revealed suggestive evidence for an antidepressant effect of metreleptin in patients with LD. Metreleptin caused a rapid drop in depression scores within 1 week of treatment. A reduction of the depression score was also observed in 2 of the 3 LD patients whose BDI scores were in the normal range before start of the treatment. The reduction in total scores of BDI was still apparent after 3 months (T4) of dosing. This observation matches findings obtained in clinical case studies of AN patients, in whom depression scores also dropped during the first week of metreleptin treatment. It needs to be noted that by the nature of this observational study without a placebo group, nonspecific treatment expectation affecting mood cannot fully be ruled out.
The Involvement of the Hypothalamus-Pituitary-Adrenal Axis in the Development of Hyperalgesia during the Early Postoperative Period
Authors: Ahn Ryun S. , Park Jin-Woo , Park In-Sun , Shin Hyun-Jung , Ryu Jung-Hee , Oh Ah-Young , Park Hee-Yeon , Do Sang-Hwan
Published: August 2022

Introduction: Hyperalgesia frequently occurs after surgery and is associated with adverse effects on surgical outcomes. Thus, we aimed to examine whether the hypothalamus-pituitary-adrenal (HPA) axis function after surgery is involved in the development of postoperative hyperalgesia. Methods: Surgery- and pain-related variables were measured 24 and 48 h after the first and second total knee arthroplasties (TKAs) in postmenopausal patients undergoing 1-week-interval staged bilateral TKA. Two sets of saliva samples were consecutively collected from patients before (pre-T1) and 1 week after (post-T1) the first TKA (n = 69). HPA axis function was analyzed in a subgroup of 20 patients with a typical cortisol awakening response (CAR) in both the sets of saliva samples. Results: Surgery-related variables were comparable between the first and second TKAs. However, pain-related variables (pain ratings and the amount of opioid analgesics consumed) were greater after the second than the first TKA. Cortisol and dehydroepiandrosterone (DHEA) secretion during the post-awakening period (CARauc and Daucawk, respectively) was higher at post-T1 than at pre-T1, but the molar CARauc/Daucawk ratio was comparable between the time points examined. No relationship was observed between the pre-T1 CARauc and pain ratings after the first TKA. However, post-T1 CARauc showed a positive correlation with pain ratings after the second TKA. Postoperative pain ratings were negatively correlated with Daucawk and positively correlated with the molar CARauc/Daucawk ratio at all examined time points. Discussion/Conclusion: The results suggest that adrenocortical steroidogenic activity favoring the production of cortisol over DHEA after surgery may contribute to the development of hyperalgesia during the early postoperative period.
Decisão do Superior Tribunal de Justiça altera o entendimento do Tribunal de Justiça de São Paulo a respeito da regulação de seguros e planos de saúde
Authors: Robba Rafael , Fernandes Caio Henrique Sampaio
Published: August 2022

O Superior Tribunal de Justiça tem utilizado, cada vez mais, o procedimento dos recursos repetitivos para construir precedentes sobre a regulação de seguros e planos de saúde. O objetivo deste artigo foi analisar como os precedentes do Superior Tribunal de Justiça, em sede de recurso repetitivo, afetam as decisões do Tribunal de Justiça do Estado de São Paulo em casos individuais. Assim, foi escolhido um caso específico decidido pelo Superior Tribunal de Justiça (Tema 989), que uniformizou a interpretação dos artigos 30 e 31 da Lei n. 9.656/1998. O método utilizado foi o de comparar as decisões do Tribunal de Justiça do Estado de São Paulo sobre a interpretação desses artigos dois anos antes e dois anos depois da decisão do Superior Tribunal de Justiça sobre o assunto. A conclusão foi de que, antes do Tema 989, o tribunal paulista decidia a favor dos ex-empregados e dos aposentados, à luz do valor constitucional da proteção do idoso e do valor contratual da boa-fé, e que depois o entendimento da corte mudou profundamente.
Falsa coletivização de planos de saúde: expansão, reajustes e judicialização (2014-2019)
Authors: Andrietta Lucas Salvador
Published: August 2022

A falsa coletivização é um fenômeno crescente no mercado brasileiro de planos e seguros de saúde. Ela decorre diretamente de decisões regulatórias que afetam o setor, especialmente as diferenças entre regras aplicáveis a contratos individuais e coletivos. O objetivo deste trabalho foi analisar a evolução recente do fenômeno sob três aspectos: (i) a expansão desse tipo de contrato, simultânea à redução de planos individuais; (ii) o diferencial acumulado de reajustes para os falsos coletivos; (iii) a sua judicialização e o tratamento dado ao tema pelo Poder Judiciário. Foram utilizados dados da Agência Nacional de Saúde Suplementar, desagregados por empresa, entre 2014 e 2019; do banco de dados de Notas Técnicas de Registro de Produto da agência, entre 2015 e 2019; e dados primários produzidos pela análise de acórdãos do Tribunal de Justiça de São Paulo, proferidos em 2018 e 2019. Os resultados evidenciaram o crescimento do fenômeno dos “falsos coletivos”, associado à gradual redução dos planos individuais. Demonstraram, também, o sistemático reajuste das mensalidades acima do teto definido pela Agência Nacional de Saúde Suplementar para planos individuais. A análise de acórdãos mostrou que o entendimento da questão pelo Poder Judiciário não é uniforme, nem em termos do resultado do julgamento, nem de sua fundamentação jurídica. Os resultados apoiam a interpretação de que esses contratos permitem às operadoras burlar aspectos relevantes da regulação do setor, impor reajustes superiores e, quando reclamadas judicialmente, escamotear a legislação consumerista.
Desigualdade da participação dos consumidores e operadoras na Agência Nacional de Saúde Suplementar
Authors: Patullo Marcos Paulo Falcone , Aith Fernando Mussa Abujamra
Published: August 2022

Participação social é um elemento fundamental para a legitimação democrática das decisões regulatórias, bem como é um importante instrumento de accountability nas agências reguladoras. O presente artigo apresenta os resultados de pesquisa quantitativa feita nos instrumentos de participação social da Agência Nacional de Saúde Suplementar, especificamente na Câmara de Saúde Suplementar, comissões e comitês da agência, audiências públicas, consultas públicas, câmaras técnicas e grupos técnicos. A pesquisa teve por objetivo mensurar a participação dos stakeholders do mercado da saúde suplementar na agência. Estes foram divididos em cinco grupos – “operadoras de planos de saúde”, “consumidores”, “prestadores de serviço da área da saúde”, “estado e servidores da ANS” e “outros” – de acordo com o interesse defendido no mercado da saúde. A pesquisa baseou-se nos documentos que registraram a utilização dos instrumentos de participação social da agência, como listas de presença, atas das reuniões e relatórios públicos. Os resultados indicam uma participação mais consistente e organizada das “operadoras de planos de saúde” e “prestadores de serviço da área da saúde”, em contraste com os “consumidores”, que participam de forma mais difusa, menos organizada e estão menos propensos a participar em câmaras técnicas e grupos técnicos, que são instrumentos que propiciam uma abordagem mais técnica ao debate regulatório.
Judicialização dos planos e seguros de saúde privados
Authors: Aith Fernando Mussa Abujamra , Scheffer Mario César
Published: August 2022

Esta edição especial da Revista de Direito Sanitário apresenta os resultados inéditos de pesquisas realizadas pelo Grupo de Estudos sobre Planos de Saúde, do Departamento de Medicina Preventiva da Faculdade de Medicina e do Centro de Estudos e Pesquisas de Direito Sanitário (Cepedisa) da Faculdade de Saúde Pública, ambos da Universidade de São Paulo.
En los orígenes de la Historia Comparativa: campos de transferencias y circulación de saberes, siglos XIX y XX
Authors: Rios Gordillo Carlos Alberto
Published: August 2022

El objetivo de este artículo es analizar la circulación del método comparativo en las ciencias sociales de los siglos XIX y XX, a través de un campo de transferencias caracterizado por una serie de conexiones, procesos superpuestos e influencias cruzadas, que hicieron de este método un paradigma científico. Por lo tanto, aquí se estudian menos las características de la historia comparada que las transferencias que la hicieron posible; menos los historiadores que los intercambios disciplinarios, las influencias recíprocas, entre ellos y con otros comparatistas. El análisis de sus obras, artículos o libros de la época, o de los que se escribieron sobre ellos, permitió reconstruir las ideas, la circulación del conocimiento y las prácticas científicas que definieron el perfil de la historia comparada, así como de la historia global, entre los historiadores franceses de la corriente de Annales.
Fatores associados aos transtornos mentais comuns entre agricultores em um município de médio porte no nordeste do Brasil
Authors: Alves Roberta Machado , Santos Emelynne Gabrielly de Oliveira , Barbosa Isabelle Ribeiro
Published: August 2022

OBJETIVO Identificar a prevalência e os fatores associados aos transtornos mentais comuns entre agricultores residentes em um município de médio porte no nordeste do Brasil, entre 2019 e 2020. MÉTODOS Entrevistadoras treinadas aplicaram o questionário padronizado em 450 participantes. Investigou-se características sociodemográficas, de saúde, renda e trabalho. O rastreamento dos transtornos mentais comuns foi realizado mediante a utilização do questionário SRQ-20 ( Self-Reporting Questionaire ), com o ponto de corte ≥ 7 para mulheres e ≥ 5 para homens. Foi aplicada a regressão de Poisson com estimação robusta para verificar as razões de prevalência na análise bivariada e multivariada. RESULTADOS A prevalência dos transtornos mentais comuns entre agricultores foi de 55,1% (IC95% 50,4–59,6). As variáveis que permaneceram significativas e associadas aos transtornos mentais comuns foram: ser do sexo masculino (RP = 1,7), ter mais de 60 anos (RP = 0,5), ter autoavaliação de saúde ruim ou muito ruim (RP = 1,4), ter realizado tratamento anterior para saúde mental (RP = 1,2), fazer uso abusivo do álcool (RP = 1,2) e ter tido perda de produção (RP = 1,3). CONCLUSÃO Esses resultados indicam que os transtornos mentais comuns estão associados a fatores individuais e do contexto de vida e trabalho dos agricultores, o que demonstra a importância do suporte social, econômico e dos serviços de saúde a esse grupo de trabalhadores.
Três décadas da disponibilidade domiciliar de alimentos segundo a NOVA – Brasil, 1987–2018
Authors: Levy Renata Bertazzi , Andrade Giovanna Calixto , Cruz Gabriela Lopes da , Rauber Fernanda , Louzada Maria Laura da Costa , Claro Rafael Moreira , Monteiro Carlos Augusto
Published: August 2022

OBJETIVO Avaliar a tendência da aquisição domiciliar de alimentos de acordo com a classificação NOVA no Brasil entre 1987–1988 e 2017–2018. MÉTODOS Foram utilizados dados de aquisição domiciliar de alimentos provenientes de cinco edições da Pesquisas de Orçamentos Familiares, realizada pelo Instituto Brasileiro de Geografia e Estatística, nos anos 1987–1988, 1995–1996, 2002–2003, 2008–2009 e 2017–2018. Todos os alimentos reportados foram categorizados segundo a classificação NOVA. A disponibilidade domiciliar dos grupos e subgrupos de alimentos foi expressa por meio de sua participação (%) nas calorias totais, para o conjunto das famílias brasileiras, por situação do domicílio (urbana ou rural), para cada uma das cinco regiões geográficas do país, por quintos da distribuição de renda domiciliar per capita (inquéritos de 2002–2003, 2008–2009 e 2017–2018); e para as 11 principais regiões urbanas do país (inquéritos de 1987–1988, 1995–1996, 2002–2003, 2008–2009 e 2017–2018). Modelos de regressão linear foram utilizados para avaliar a tendência de aumento ou diminuição na aquisição dos alimentos. RESULTADOS A dieta da população brasileira ainda é composta predominantemente por alimentos in natura e minimamente processados e ingredientes culinários processados. No entanto, nossos achados apontam tendências de aumento da participação de alimentos ultraprocessados na dieta. Esse aumento que foi de 0,4 pontos percentuais ao ano na primeira porção do período estudado, entre 2002 e 2009, e desacelerou para 0,2 pontos percentuais entre 2008 e 2018. O consumo de alimentos ultraprocessados foi maior entres os domicílios de maior renda, nas regiões Sul e Sudeste, na área urbana, e nas regiões metropolitanas. CONCLUSÃO Os resultados do presente estudo apontam um aumento na participação de alimentos ultraprocessados na dieta dos brasileiros. Cenário preocupante, uma vez que o consumo de tais alimentos está associado ao desenvolvimento de doenças e à perda da qualidade nutricional da dieta.
Long-Term Evolocumab in Patients With Established Atherosclerotic Cardiovascular Disease
Authors: O’Donoghue Michelle L. , Giugliano Robert P. , Wiviott Stephen D. , Atar Dan , Keech Anthony , Kuder Julia F. , Im KyungAh , Murphy Sabina A. , Flores-Arredondo Jose H. , López J. Antonio G. , Elliott-Davey Mary , Wang Bei , Monsalvo Maria Laura , Abbasi Siddique , Sabatine Marc S.
Published: August 2022

Background:

In FOURIER (Further Cardiovascular Outcomes Research With PCSK9 Inhibition in Subjects With Elevated Risk), the proprotein convertase subtilisin-kexin type 9 inhibitor evolocumab reduced low-density lipoprotein cholesterol (LDL-C) and risk of cardiovascular events and was safe and well tolerated over a median of 2.2 years of follow-up. However, large-scale, long-term data are lacking.

Methods:

The parent FOURIER trial randomized 27 564 patients with atherosclerotic cardiovascular disease and LDL-C ≥70 mg/dL on statin to evolocumab versus placebo. Patients completing FOURIER at participating sites were eligible to receive evolocumab in 2 open-label extension studies (FOURIER-OLE [FOURIER Open-Label Extension]) in the United States and Europe; primary analyses were pooled across studies. The primary end point was the incidence of adverse events. Lipid values and major adverse cardiovascular events were prospectively collected.

Results:

A total of 6635 patients were enrolled in FOURIER-OLE (3355 randomized to evolocumab and 3280 to placebo in the parent study). Median follow-up in FOURIER-OLE was 5.0 years; maximum exposure to evolocumab in parent plus FOURIER-OLE was 8.4 years. At 12 weeks in FOURIER-OLE, median LDL-C was 30 mg/dL, and 63.2% of patients achieved LDL-C <40 mg/dL on evolocumab. Incidences of serious adverse events, muscle-related events, new-onset diabetes, hemorrhagic stroke, and neurocognitive events with evolocumab long term did not exceed those for placebo-treated patients during the parent study and did not increase over time. During the FOURIER-OLE follow-up period, patients originally randomized in the parent trial to evolocumab versus placebo had a 15% lower risk of cardiovascular death, myocardial infarction, stroke, or hospitalization for unstable angina or coronary revascularization (hazard ratio, 0.85 [95% CI, 0.75–0.96];
P
=0.008); a 20% lower risk of cardiovascular death, myocardial infarction, or stroke (hazard ratio, 0.80 [95% CI, 0.68–0.93];
P
=0.003); and a 23% lower risk of cardiovascular death (hazard ratio, 0.77 [95% CI, 0.60–0.99];
P
=0.04).

Conclusions:

Long-term LDL-C lowering with evolocumab was associated with persistently low rates of adverse events for >8 years that did not exceed those observed in the original placebo arm during the parent study and led to further reductions in cardiovascular events compared with delayed treatment initiation.

Registration:

URL:
https://www.clinicaltrials.gov
; Unique identifiers: NCT02867813 and NCT03080935.
Forced Displacement, Prevention from Returning and the Jurisdiction of the International Criminal Court
Authors: Katselli Proukaki Elena
Published: August 2022

This article argues that international criminal law has not adequately addressed the true dimensions and effects of forced displacement. Often protracted in time, forced displacement extends well beyond the conduct of coercively expelling individuals out of territory from which they are lawfully present. Preventing those forcibly displaced from returning is an essential element of forced displacement as a crime against humanity and as such, it requires the full reprehension of international criminal law. This means that the crime continues for as long as prevention from returning is sustained with significant ramifications on the temporal and territorial jurisdiction of the International Criminal Court. This is particularly so in relation to crimes elements of which are committed in the territory of a state not party to the icc Statute, such as in the situation concerning the alleged deportation of the Rohingya before the icc, and crimes which were initiated before the binding force of the icc Statute. The article concludes that recognition of prevention from returning as a continuing element of forced displacement does not infringe state consent, nor does it compromise the principle of legality which are central to the exercise of icc jurisdiction.
Case Note on the Supreme Court of Denmark’s Judgment in Green Desert
Authors: Kjeldgaard-Pedersen Astrid , Nielsen Rasmus Grønved
Published: August 2022

This case note accounts for and comments on the Supreme Court of Denmark’s recent judgment in the Green Desert case. The Court held that the Ministry of Defence was not liable under Danish tort law for the Danish troops’ participation in the Green Desert operation in 2004 in Iraq, during which a number af Iraqis were detained and later subjected to inhuman treatment by the Iraqi police and military. Moreover, the Supreme Court found that the Iraqis were not within the jurisdiction of Denmark under Article 1 echr. The judgment did not address the general rules on state responsibility or international humanitarian law.
Taxonomic notes Portulaca (Portulacaceae) in South America I: the taxonomic status of P. mucronulata var. microphylla
Authors: FERRAZ JOSÉ ROBERTO , ROSSETTO ELSON FELIPE SANDOLI , RIBEIRO JOSÉ EDUARDO L. S. , HASSEMER GUSTAVO
Published: August 2022

Taxonomy of the South American Portulaca is advancing considerably but many problems and knowledge gaps still remain. As a result of further investigation of the genus, P. ferricola is here proposed as new name to replace, at species rank, the hitherto overlooked P. mucronulata var. microphylla. P. ferricola is a species endemic to ironstone grasslands from eastern Bolivia and central-western Brazil, whose conservation status is here assessed as Endangered (EN). In addition to a discussion of the taxonomy, ecology, and conservation status of the species, we also provide photographs of herbarium specimens and the species in natura.
Soil Carbon Losses Reduce Soil Moisture in Global Climate Model Simulations
Authors: McDermid Sonali Shukla , Weng Ensheng , Puma Michael , Cook Benjamin , Hengl Tomislav , Sanderman Jonathan , De Lannoy Gabrielle J. M. , Aleinov Igor
Published: August 2022

Most agricultural soils have experienced substantial soil organic carbon losses in time. These losses motivate recent calls to restore organic carbon in agricultural lands to improve biogeochemical cycling and for climate change mitigation. Declines in organic carbon also reduce soil infiltration and water holding capacity, which may have important effects on regional hydrology and climate. To explore the regional hydroclimate impacts of soil organic carbon changes, we conduct new global climate model experiments with NASA Goddard Institute for Space Studies ModelE that include spatially explicit soil organic carbon concentrations associated with different human land management scenarios. Compared to a “no land use” case, a year 2010 soil degradation scenario, in which organic carbon content (OCC; weight %) is reduced by a factor of ∼0.12 on average across agricultural soils, resulted in soil moisture losses between 0.5 and 1 temporal standard deviations over eastern Asia, northern Europe, and the eastern United States. In a more extreme idealized scenario where OCC is reduced uniformly by 0.66 across agricultural soils, soil moisture losses exceed one standard deviation in both hemispheres. Within the model, these soil moisture declines occur primarily due to reductions in porosity (and to a lesser extent infiltration) that overall soil water holding capacity. These results demonstrate that changes in soil organic carbon can have meaningful, large-scale effects on regional hydroclimate and should be considered in climate model evaluations and developments. Further, this also suggests that soil restoration efforts targeting the carbon cycle are likely to have additional benefits for improving drought resilience.
Dynamical Core Damping of Thermal Tides in the Martian Atmosphere
Authors: Lian Yuan , Richardson Mark I. , Newman Claire E. , Lee Chris , Toigo Anthony , Guzewich Scott , Yelle Roger V.
Published: August 2022

Atmospheric oscillations with daily periodicity are observed in in situ near-surface pressure, temperature, and winds observations and also in remotely sensed temperature and pressure observations of the Martian atmosphere. Such oscillations are interpreted as thermal tides driven by the diurnal cycle of solar radiation and occur at various frequencies, with the most prominent being the diurnal, semidiurnal, terdiurnal, and quadiurnal tides. Mars global circulation models reproduce these tides with varying levels of success. Until recently, both the MarsWRF and newly developed MarsMPAS models were able to produce realistic diurnal and semidiurnal tide amplitudes but predicted higher-order mode amplitudes that were significantly weaker than observed. We use linear wave analysis to show that the divergence damping applied within both MarsWRF and MarsMPAS is responsible for suppressing the amplitude of thermal tides with frequency greater than 2 per sol, despite being designed to suppress only acoustic wave modes. Decreasing the strength of the divergence damping in MarsWRF and MarsMPAS allows for excellent prediction of the higher-order tidal modes. This finding demonstrates that care must be taken when applying numerical dampers and filters that may eliminate some desired dynamical features in planetary atmospheres.
Variations of Summertime SSTA Independent of ENSO in the Maritime Continent and Their Possible Impacts on Rainfall in the Asian–Australian Monsoon Region
Authors: Zhu Jing , Guan Zhaoyong , Wang Xudong
Published: August 2022

The sea surface temperature anomalies (SSTA) in the Maritime Continent (MC) region are mainly related to local variability, ENSO, and the Indian Ocean dipole. Using the reanalysis data from NOAA and NCEP–NCAR, by employing the empirical orthogonal function (EOF) analysis, we have explored the principal mode of ENSO-independent summertime SSTA in the MC and its associations with regional climate anomalies. After ENSO signals have been removed, the leading mode of SSTA in the MC exhibits a uniformly signed pattern, which mainly varies on an interannual time scale. The maintenance mechanisms of the ENSO-independent SSTA are different in different subregions, especially over the region south of Java and the tropical northwestern Pacific. When the time coefficient of the first leading EOF mode (EOF1) is positive, warmer SSTAs are observed in the area south of Java. The oceanic dynamic heating there facilitates the warmer SSTA. Thus, the Gill-type response of the atmosphere is found over the region south of Java. The diabatic cooling in the atmosphere is dominant over the tropical northwestern Pacific where the warmer SSTA is maintained by the absorption of solar radiation due to less cloud cover there. A tilted vertical circulation is hence formed, linking the tropical southeastern Indian Ocean with the tropical northwestern Pacific. The anomalous circulations in the Asian–Australian monsoon region are affected by this ENSO-independent SSTA mode, resulting in decreased summer rainfall anomaly in the region near the southeast coast of China and increased winter precipitation anomaly over the extratropical region of Australia.
Temperatures of Anvil Clouds and Radiative Tropopause in a Wide Array of Cloud-Resolving Simulations
Authors: Seidel Seth D. , Yang Da
Published: August 2022

We present 123 cloud-resolving simulations to study how temperatures of anvil clouds and radiative tropopause (RT) change with surface warming. Our simulation results show that the RT warms at approximately the same rate as anvil clouds. This relationship persists across a variety of modeling choices, including surface temperature, greenhouse gas concentration, and the representation of radiative transfer. We further show that the shifting ozone profile associated with climate warming may give rise to a fixed RT temperature as well as a fixed anvil temperature. This result points to the importance of faithful treatment of ozone in simulating clouds and climate change; the robust anvil–RT relationship may also provide alternative ways to understand what controls anvil temperature.
Warmer SSTs in the Equatorial Eastern Pacific Delay the Seasonal March of the Asian–Pacific Summer Monsoon Onset
Authors: Ling Sining , Lu Riyu
Published: August 2022

This study investigates the impact of El Niño–Southern Oscillation (ENSO) on the seasonal evolution of the Asian–Pacific summer monsoon. The results show that during the summers when the SSTs in the equatorial eastern Pacific are above normal (i.e., during developing El Niño), the seasonal march of the Asian–Pacific summer monsoon is delayed. Specifically, the stepwise northeastward extension of the western North Pacific monsoon and the northward migration of East Asian and Indian monsoon are all delayed, resulting in rainfall deficiency in the western North Pacific and India, and more rainfall in the Yangtze River valley but less rainfall in North China due to the delayed northward migration and resultant prolonged rainy season in the Yangtze River valley. In addition, the seasonal march of the Asian upper-tropospheric westerly jet, which is mainly characterized by the northward migration during the monsoon development, is also delayed, concurrent with the delayed march of monsoonal rainfall. During La Niña summers, however, the seasonal march of the monsoon and Asian jet does not exhibit clear variations, suggesting asymmetrical impacts between El Niño and La Niña. Furthermore, we explain these variations in the seasonal evolution of rainfall and jet and the asymmetrical impacts between El Niño and La Niña through the variations in tropical tropospheric temperatures and the resultant changes in meridional temperature gradient.

Significance Statement

The seasonal march of the Asian–Pacific summer monsoon exhibits large spatial and temporal variations, but shows some regular features such as stepwise northward migrations. The impacts of ENSO on the seasonal evolution of the components of Asian–Pacific summer monsoon have been shown in previous studies. However, there have been remarkable uncertainties in the previous results, and more emphasis has been put on the impacts of preceding ENSO. This study starts from El Niño and La Niña summers to reduce uncertainty caused by defining the seasonal march of the monsoon, and includes the variations in circulations that correspond well to monsoonal rainfall, making the conclusions more reliable.
Changes in Aerosols, Meteorology, and Radiation in the Southeastern U.S. Warming Hole Region during 2000 to 2019
Authors: Ghate Virendra P. , Carlton Annmarie G. , Surleta Thomas , Burns Alyssa Marie
Published: August 2022

Surface air temperatures in the southeastern United States that did not change from the climatological mean from 1900 to 2000 have increased since the year 2000. Analyzed herein are factors modulating the surface air temperatures in the region for a 20-yr period (2000–19) using space- and surface-based observations, and output from a reanalysis model. The 20-yr period is segregated into two decades, 2000–09 and 2010–19, corresponding to different tropospheric chemical regimes. Changes in seasonal and decadal averages are examined. The later decade experienced higher average surface air temperatures with significant warming during summer and fall seasons. Decadal and seasonal averages of cloud properties, column water vapor, rain rates, and top-of-atmosphere outgoing longwave radiation did not exhibit statistically significant differences between the two decades. The region experienced strong warm and moist advection during the winter months and very weak advection during the summer months. The later decade exhibited higher low-level moisture advection during the winter months than the earlier decade with insignificant changes in the temperature advection between the two decades. The later decade had significantly lower aerosol dry and liquid water mass during all seasons, along with lower aerosol optical depth, higher single scattering albedo, and lower top-of-the-atmosphere outgoing shortwave radiation during cloud-free conditions in the summer season. Collectively, these results suggest that changes in the aerosol direct radiative forcing are responsible for warming during summer months that experience weak advection and highlight seasonal differences in the temperature controlling mechanisms in the region.
Climate Feedback to Stratospheric Aerosol Forcing: The Key Role of the Pattern Effect
Authors: Günther Moritz , Schmidt Hauke , Timmreck Claudia , Toohey Matthew
Published: August 2022

Volcanic aerosol forcing has previously been found to cause a weak global mean temperature response, as compared with CO2 radiative forcing of equal magnitude: its efficacy is supposedly low, but for reasons that are not fully understood. To investigate this, we perform idealized, time-invariant stratospheric sulfate aerosol forcing simulations with the MPI-ESM-1.2 and compare them with 0.5 × CO2 and 2 × CO2 runs. While the early decades of the aerosol forcing simulations are characterized by strong negative feedback (i.e., low efficacy), the feedback weakens on the decadal to centennial time scale. Although this effect is qualitatively also found in CO2-warming simulations, it is more pronounced for stratospheric aerosol forcing. The strong early and weak late cooling feedbacks compensate, leading to an equilibrium efficacy of approximately 1 in all simulations. The 0.5 × CO2 cooling simulations also exhibit strong feedback changes over time, albeit less than in the idealized aerosol forcing simulations. This suggests that the underlying cause for the feedback change is not exclusively specific to aerosol forcing. One critical region for the feedback differences between simulations with negative and positive radiative forcing is the tropical Indo-Pacific warm-pool region (30°S–30°N, 50°E–160°W). In the first decades of cooling, the temperature change in this region is stronger than the global average, whereas it is stronger outside it for 2 × CO2 warming. In cooling scenarios, this leads to an enhanced activation of the warm-pool region’s strongly negative lapse-rate feedback.

Significance Statement

Large volcanic eruptions can enhance the scattering aerosol layer in the stratosphere, which leads to a global cooling for a few years. Surprisingly, Earth has been found to cool less from radiative flux perturbations from stratospheric aerosol forcing, in comparison with how much it warms as a result of increases in CO2 concentration. We find that specific surface temperature change patterns after volcanic eruptions cause this effect. The temperature change in the tropical Indian and western Pacific Ocean determines how much global temperature change is needed to regain radiative equilibrium. Our findings contribute to understanding the climate response to volcanic eruptions and are relevant for understanding the mechanisms of climate change due to changes in CO2 concentration.
Australia’s Future Extratropical Cyclones
Authors: Pepler Acacia S. , Dowdy Andrew J.
Published: August 2022

Extratropical cyclones are responsible for the majority of total and extreme rainfall in many regions of the extratropics, including in southern Australia. Using an ensemble of projections from 12 regional climate models, we show that both the number of cyclone days and total cyclone-related rainfall are projected to decline across southern Australia during the twenty-first century. This is a robust signal in projections across models and explains more than 80% of projected declines in total cool-season rainfall in the region. Using cyclone-centered composites, we show that cyclone intensity based on wind speed is projected to decrease but cyclone maximum rainfall is projected to increase by close to 7% K−1 in the southeast. This results in a shift in the distribution of cyclone rainfall, with a decrease in moderate rainfall but little change or an increase in extreme rainfall.

Significance Statement

Extratropical cyclones are very important for southern Australian rainfall, and they are expected to become less frequent in a warming climate. Our research shows this explains at least 80% of the projected decline in cool-season rainfall in southern Australia. However, the frequency of extratropical cyclones with very heavy rainfall may increase, particularly in Tasmania and the southeast coast, with increases in rainfall intensity in line with the Clausius–Clapeyron relationship. This contributes to increases in the frequency of very heavy rainfall in the future.