bluuebunny/crossref_metadata_2025 huggingface dataset:
Un paisaje andino como hábitat de una fauna determinada, Chile
Authors: Jaime-Muñoz Eduardo A.
Published: August 2024

El objetivo de este artículo fue analizar el entorno natural de los potreros de El Rincón, en la provincia del Limarí, donde habita una comunidad de aves silvestres. La metodología empleada incluyó trabajo de campo con observación directa, aplicación de hojas de registro para los individuos avistados, elaboración de cartografía con el programa ArcMap 10.1, toma de fotografías, y realización de ilustraciones de aves utilizando lápices Giotto, block, lápiz carbón, goma común y goma moldeable. Además, se llevó a cabo una revisión bibliográfica para complementar los datos obtenidos. Los hallazgos revelaron la presencia de diecinueve especies en tres zonas geográficas distintas. Estas aves coexisten en un hábitat amenazado por incendios forestales, deforestación del bosque nativo y cambio climático. Entre las especies observadas, la turca es endémica, la tenca es cuasi endémica y la perdiz es endémica. También se presenta un mapa temático del área de estudio junto con cuatro ilustraciones de algunas de las aves avistadas.
Sistema de numeración quinario, en los motivos 19, 20 y 21 del sector D en Quilla Rumi, Huánuco
Authors: Alomia-Lucero José M. , Sixto-Dávila Liana
Published: August 2024

Quilla Rumi alberga más de 200 pinturas rupestres que aún no han sido descifradas, lo que abre la posibilidad de analizarlas desde un enfoque científico para profundizar en el conocimiento de los primeros habitantes y su identidad cultural en relación con el pasado histórico de Huánuco. El propósito del estudio fue demostrar que los motivos 19, 20 y 21 del sector D en Quilla Rumi representan el sistema de numeración quinario de los antiguos pobladores de la región. Se empleó un enfoque cualitativo, de tipo documental y métodos analítico-sintéticos para analizar las imágenes de las pinturas rupestres. El análisis de estos tres motivos reveló sus interrelaciones. Se concluye que el motivo 20, con cuatro puntos y una línea, representa el número cinco, considerado como una mano en el sistema de numeración quinario. El motivo 21, con un cuadrado y un punto central, también simboliza el número cinco, pero de manera más avanzada y práctica. El motivo 19 representa el número 25 o cinco manos, y al incluir la cabeza con dos ojos y una nariz, podría representar 28 días, el ciclo lunar. Además, la cabeza de la figura se identifica como la de un perro peruano debido a sus características morfológicas.
El santuario histórico de Chacamarca, como servicio ecoturístico en Junín
Authors: Acuña-Aguilar Grimaldo R.
Published: August 2024

El estudio tuvo como objetivo evaluar el funcionamiento del Santuario Histórico de Chacamarca como un servicio ecoturístico en Junín, y evaluar el grado de satisfacción de los usuarios. Esto permitirá examinar las implicaciones el ecoturismo en Chacamarca para las comunidades locales, considerando que el desarrollo del ecoturismo sostenible puede generar empleo, diversificar la economía local y promover la participación comunitaria en la gestión de recursos naturales y culturales. El estudio fue de tipo básico, tuvo un enfoque cuantitativo, diseño no experimental y nivel descriptivo. La población estuvo conformada por los habitantes de los cuatro distritos: Carhuamayo, Ondores, Ulcumayo y Junín. La muestra fueron 379 habitantes de los mencionados distritos. Para recoger los datos se empleó un cuestionario de 14 ítems. La satisfacción de los turistas en el Santuario Histórico de Chacamarca depende de la calidad de los servicios y la infraestructura, y mejorar la accesibilidad y los servicios básicos es fundamental. El ecoturismo puede tener un impacto significativo en la población de Junín, generando empleo y diversificando la economía local, al mismo tiempo que promueve el desarrollo sostenible y la conservación del patrimonio natural y cultural.
Estilos de crianza y regulación emocional en estudiantes de una institución educativa de Villa El Salvador, Perú
Authors: Soto-Ortiz Yajhaira L. , Morales-John Cielo V. , Guerrero-Alcedo Jesús M.
Published: August 2024

Esta investigación tuvo como propósito establecer relación entre los estilos de crianza y regulación emocional evaluando a 267 adolescentes de 13 a 19 años de secundaria en un centro educativo del distrito de Villa el Salvador, Lima. Con un enfoque cuantitativo con diseño no experimental transversal y alcance correlacional. Se aplicó la escala de estilos de crianza y el cuestionario de regulación emocional. Los resultados indican que el estilo de crianza que más predomina entre los adolescentes es el autoritativo, con 201 participantes, seguido por el mixto con 32, el permisivo con 21, el autoritario con 11 y el negligente con 2. Asimismo, el 44.6% de los escolares presentan un nivel medio de regulación emocional. Además, se observó que una mayor autonomía psicológica está relacionada con mejores estrategias de autorregulación emocional. Esto confirma que existe una relación entre ambas variables y permite precisar que un estilo de crianza adecuado se asocia con mayores niveles de regulación emocional.
Research on Exposure to Salt Water Environment of Fe-based Amorphous Alloy Coating Fabricated by Twin Wire Arc Spray
Authors: Kwon Hansol , Kang Yongjin , Yoo Yeonwoo , Kim Dohyeon , Park Youngjin , Nam Uk Hee , Byon Eungsun
Published: August 2024

Fe-based amorphous alloys are promising structural materials that have a disordered lattice structure and metastable state. Due to their advanced properties, including high hardness, high elastic limit, improved wear and corrosion resistance, Fe-based amorphous alloys have a great potential for protective materials in harsh industrial fields. Twin wire arc spray (TWAS), which is a kind of thermal spray process, is a reasonable choice for depositing Fe-based amorphous coating. Industrial advantages of TWAS include simple apparatus, low cost, excellent field usability. Several previous studies of TWAS Fe-based amorphous coating have reported microstructural features, the effect of major element variation, and the effect of post-heat treatment. Unfortunately, studies about Fe-based amorphous coating exposed to soluble salt solution are limited. Thus, a Fe-based amorphous coating was fabricated using TWAS in this study, and the effect of 3.5 wt.% NaCl solution exposure on its microstructure and mechanical properties was researched. Single- and multi-layer coatings were fabricated and Al-3%Ti was selected as a bond coat material. The results showed that single- and multi-layer Fe-amorphous coatings were successfully deposited on high strength low alloyed (HSLA) steel, which is a representative structural material for offshore construction. The single-layer coating showed continuous corrosion and the multi-layer coating showed delamination induced by Al-3%Ti bond coat galvanic corrosion. The Vickers hardness of the coating was retained after the long-term salt solution immersion test, thus, the feasibility of single-layer Fe-amorphous coating was confirmed.
Differential Analysis of Surface-Dominated vs. Bulk-Dominated Electrochemical Processes in Lithium Iron Phosphate Cathodes
Authors: Park Byoung-Nam
Published: August 2024

We employed electrophoretic deposition (EPD) using AC voltage to prepare lithium iron phosphate (LFP) Li-ion battery electrodes with varying the LFP thickness, to compare bulk-limited electro chemical reaction with the surface-limited electrochemical reactions. We analyzed the electrochemical performances of the thin and thick LFP electrodes at various scan rates. They revealed that with increasing scan rates, both electrode types showed a greater reliance on surface capacitive effects for charge storage. Significantly, the thin LFP electrode predominantly exhibited capacitive charge storage, surpassing diffusion-based storage mechanisms. This was in contrast to the performance of the thicker electrode, which had a lower capacitive contribution. Quantitative assessment using the Randles-Sevcik equation further confirmed the superior performance of the thin LFP electrode. The Li-ion diffusion coefficient of the thin LFP electrode was substantially higher (9.6×10-9 cm2·V-1·s-1) compared to the thick electrode (2.0×10-9 cm2·V-1·s-1), indicating enhanced ionic mobility in the surface-limited electrochemical reaction. These findings emphasize the significant advantages of thinner LFP electrodes, and induced surface limited electrochemical reaction, in high-rate applications, including higher capacitive charge storage and more favorable ion diffusion characteristics. The advantages conferred by the enhanced capacitive charge storage and superior ion diffusion in thin LFP electrodes have profound implications for the design and optimization of next-generation high-rate batteries. By focusing on tailoring electrode thickness, we can harness the full potential of surface-limited reactions, pushing the boundaries of what is currently achievable in terms of power density, charging speed, and cycle life in LFP-based energy storage technologies. These enhancements align with the growing need for high-performing, reliable energy storage solutions in an increasingly electrified and energy-conscious world.
Ethnicity in Print Media: Alternative Framings of the Short Story “The Gray Robe”
Authors: De Grandis Mario
Published: August 2024

Prior research on ethnic minority literature has primarily focused on “ground-level” analysis, namely close reading of literary texts by authors registered as members of one of the ethnic minorities officially recognized by the PRC. In this paper, instead, I consider the “external” framings assigned by publishers to a case study: “ The Gray Robe,” a short story by the Hui Muslim author Shi Shuqing. Publishers have framed this story as “ethnic literature” but also as “regional,” “Chinese,” and “Chinese Muslim” literature. These competing framings, I claim, are not simple promotional devices. Rather, they highlight the latent discourses that posit a civilized literary center versus an unrefined literary periphery. Investigating how publishers package literary works for readers’ consumption enables an understanding of the tacit power dynamics within the modern literary field of China.
Penerapan Nilai-Nilai Pendidikan Agama Islam dalam Meningkatkan Kedisiplinan Melalui Program Bimbingan dan Konseling di SMK Sultan Agung 1 Tebuireng
Authors: Izzatul Ma'rifah  , Syamsuddin
Published: August 2024

Penerapan nilai-nilai PAI menanamkan akidah, ibadah, dan akhlak. Disiplin bagian penting dari kehidupan seperti aturan tentang memanfaatkan waktu dengan baik. Guru bimbingan dan konseling telah menanamkan disiplin kepada siswa serta memiliki pendekatan sesuai untuk mengatasi masalah kedisiplinan siswa. Fokus penelitian; 1). Bagaimana penerapan nilai- nilai PAI  dalam meningkatkan kedisiplinan siswa di SMK Sultan Agung 1 Tebuireng, 2). Bagaimana penerapan nilai- nilai PAI dalam  meningkatkan kedisiplinan siswa melalui program bimbingan dan konseling di SMK Sultan Agung 1 Tebuireng, 3). Apa saja faktor pendukungdan penghambat penerapan nilai- nilai PAI dalam meningktkan kedisiplinan siswa melalui program bimbingana dan konseiling di SMK Sultan Agung1 Tebuireng. Penelitian ini jenisnya adalah studi kasus, penelitian ini menggunakan pendekatan sebuah kualitatif, adapun pengumpulan data dengan observasi atau pengamatan, bertanya atau wawancara, serta dokumentasi. Hasil penelitiannya; 1). SMK Sultan Agung 1 Tebuireng menerapkan nilai-nilai PAI untuk meningkatkan kedisiplinan siswa dengan melewati berbagai tata tertib dan kegiatan keagamaan. Nilai Akidah; pemahaman tentang keyakinan dalam agama Islam. Nilai Ibadah; Siswa melaksanakan sholat berjama’ah dan praktik keagamaan lainnya. Nilai Akhlak; Penerapan tawadhu yang baik atau rasa hormat kepada yang lebih tua. 2). Nilai kedisiplinan; a). Disiplin Waktu, siswa tiba ke sekolah sesuai aturan sekolah, mengerjakan tugas tepat waktu. b). Disiplin Perbuatan, menerapkan aturan dan sanksi untuk memastikan kedisiplinan. Nilai bimbingan dan konseling meliputi; a). Bersikap Terbuka, Siswa merasa diperhatikan membuat mereka lebih menerima bimbingan dari guru bimbingan dan konseling. b). Humanistik, interaksi personal dengan siswa untuk memahami masalah mereka serta pemberian solusi. 3). Faktor pendukung dan penghambat tergantung latar belakang siswa, karena tingkat kedisiplinannya bermacam.
An attempt to prove Riemann
Authors: Basheer Arshed
Published: August 2024

Th is an attempt to formally prove Riemann’s hypothesis (RH) related to the non-trivial zeros of the Riemann- Euler Zeta function, which are postulated by the hypothesis to lie on the critical line σ = 1/2. This paper depends on chapter 1 and chapter 2 from H.M. Edwards’ book “Riemann Zeta function” and it provides three different proofs of RH, all these proofs start from the somehow modified Xi function ξ(x), which is defined based on the functional equation of the Zeta function, separates it into real u(σ,t) and imaginary v(σ,t) parts, then equates both of them to zero and investigates the behavior of the resulting pair of equations u(σ,t) = 0 and v(σ,t) =0. The first proof investigates the algebraic and geometric structure of the Zeta function non-trivial zeros as dictated by the functional equation, using fundamental concepts from complex algebra and analytic geometry usually taught in high schools, the second proof simply depends on studying the validity of equality relation in the pair of equations u(σ,t) = 0 and v(σ,t) =0 in certain regions covering the whole plane and focusing on the critical strip. These regions are constructed based on a hyperbola relating σ and t and it results from rationalization of the equation u(σ,t) = 0. The last proof utilizes fundamental concepts from infinite series and products of trigonometric and hyperbolic functions to prove Riemann’s hypothesis.
Materials based on biodegradable polymers chitosan/gelatin: a review of potential applications
Authors: Yarahmadi Aref , Dousti Behrooz , Karami-Khorramabadi Mahdi , Afkhami Hamed
Published: August 2024

Increased mass manufacturing and the pervasive use of plastics in many facets of daily life have had detrimental effects on the environment. As a result, these worries heighten the possibility of climate change due to the carbon dioxide emissions from burning conventional, non-biodegradable polymers. Accordingly, biodegradable gelatin and chitosan polymers are being created as a sustainable substitute for non-biodegradable polymeric materials in various applications. Chitosan is the only naturally occurring cationic alkaline polysaccharide, a well-known edible polymer derived from chitin. The biological activities of chitosan, such as its antioxidant, anticancer, and antimicrobial qualities, have recently piqued the interest of researchers. Similarly, gelatin is a naturally occurring polymer derived from the hydrolytic breakdown of collagen protein and offers various medicinal advantages owing to its unique amino acid composition. In this review, we present an overview of recent studies focusing on applying chitosan and gelatin polymers in various fields. These include using gelatin and chitosan as food packaging, antioxidants and antimicrobial properties, properties encapsulating biologically active substances, tissue engineering, microencapsulation technology, water treatment, and drug delivery. This review emphasizes the significance of investigating sustainable options for non-biodegradable plastics. It showcases the diverse uses of gelatin and chitosan polymers in tackling environmental issues and driving progress across different industries.
Hemodynamic influence of mild stenosis morphology in different coronary arteries: a computational fluid dynamic modelling study
Authors: Chen Xi , Cao Haoyao , Li Yiming , Chen Fei , Peng Yong , Zheng Tinghui , Chen Mao
Published: August 2024

Introduction: Mild stenosis [degree of stenosis (DS) < 50%] is commonly labeled as nonobstructive lesion. Some lesions remain stable for several years, while others precipitate acute coronary syndromes (ACS) rapidly. The causes of ACS and the factors leading to diverse clinical outcomes remain unclear.

Method: This study aimed to investigate the hemodynamic influence of mild stenosis morphologies in different coronary arteries. The stenoses were modeled with different morphologies based on a healthy individual data. Computational fluid dynamics analysis was used to obtain hemodynamic characteristics, including flow waveforms, fractional flow reserve (FFR), flow streamlines, time-average wall shear stress (TAWSS), and oscillatory shear index (OSI).

Results: Numerical simulation indicated significant hemodynamic differences among different DS and locations. In the 20%–30% range, significant large, low-velocity vortexes resulted in low TAWSS (<4 dyne/cm2) around stenoses. In the 30%–50% range, high flow velocity due to lumen area reduction resulted in high TAWSS (>40 dyne/cm2), rapidly expanding the high TAWSS area (averagely increased by 0.46 cm2) in left main artery and left anterior descending artery (LAD), where high OSI areas remained extensive (>0.19 cm2).

Discussion: While mild stenosis does not pose any immediate ischemic risk due to a FFR > 0.95, 20%–50% stenosis requires attention and further subdivision based on location is essential. Rapid progression is a danger for lesions with 20%–30% DS near the stenoses and in the proximal LAD, while lesions with 30%–50% DS can cause plaque injury and rupture. These findings support clinical practice in early assessment, monitoring, and preventive treatment.
Lactic acid production by Lactobacillus casei using a sequence of seasonally available fruit wastes as sustainable carbon sources
Authors: Costa Stefania , Summa Daniela , Radice Matteo , Vertuani Silvia , Manfredini Stefano , Tamburini Elena
Published: August 2024

Introduction: Lactic acid (LA) production from fossil resources is unsustainable owing to their depletion and environmental concerns. Thus, this study aimed to optimize the production of LA by Lactobacillus casei in a cultured medium containing fruit wastes (FWs) from agro-industries and second cheese whey (SCW) from dairy production, supplemented with maize steep liquor (MSL, 10% v/v) as the nitrogen source.

Methods: The FWs were selected based on seasonal availability [early summer (early ripening peach), full summer (melon), late summer (pear), and early autumn (apple)] and SCW as annual waste. Small-scale preliminary tests as well as controlled fermenter experiments were performed to demonstrate the potential of using various food wastes as substrates for LA fermentation, except for apple pomace.

Results and discussion: A 5-cycle repeated batch fermentation was conducted to optimize waste utilization and production, resulting in a total of 180.56 g/L of LA with a volumetric productivity of 0.88 g/L∙h. Subsequently, mechanical filtration and enzymatic hydrolysis were attempted. The total amount of LA produced in the 5-cycle repeated batch process was 397.1 g/L over 288 h, achieving a volumetric productivity of 1.32 g/L∙h. These findings suggest a promising biorefinery process for low-cost LA production from agri-food wastes.
Evaluation of the effect of GSK-3β on liver cancer based on the PI3K/AKT pathway
Authors: Guo Jiageng , Jiang Xinya , Lian Jing , Li Huaying , Zhang Fan , Xie Jinling , Deng Jiagang , Hou Xiaotao , Du Zhengcai , Hao Erwei
Published: August 2024

The PI3K/AKT/GSK-3β signaling pathway plays a pivotal role in numerous physiological and pathological processes, including cell proliferation, apoptosis, differentiation, and metabolic regulation. Aberrant activation of the PI3K/AKT pathway is intricately linked to development of tumor. GSK-3β, belonging to the serine/threonine protein kinase family, is crucial in the pathogenesis of liver cancer. As a key rate-limiting enzyme in the glucose metabolism pathway, GSK-3β significantly impacts the growth, proliferation, metastasis, and apoptosis of liver cancer cells. It is also implicated in chemotherapy resistance. Elevated expression of GSK-3β diminishes the sensitivity of liver cancer cells to chemotherapeutic agents, thereby playing a substantial role in the development of drug resistance. Consequently, targeting of GSK-3β, particularly within the PI3K/AKT signaling pathway, is regarded as a promising therapeutic strategy for liver cancer. The precise identification and subsequent modulation of this pathway represent a substantial potential for innovative clinical interventions in the management of liver cancer.
Continuous remote monitoring of neurophysiologic Immersion accurately predicts mood
Authors: Merritt Sean H. , Zak Paul J.
Published: August 2024

Mental health professionals have relied primarily on clinical evaluations to identify in vivo pathology. As a result, mental health is largely reactive rather than proactive. In an effort to proactively assess mood, we collected continuous neurophysiologic data for ambulatory individuals 8–10 h a day at 1 Hz for 3 weeks (N = 24). Data were obtained using a commercial neuroscience platform (Immersion Neuroscience) that quantifies the neural value of social-emotional experiences. These data were related to self-reported mood and energy to assess their predictive accuracy. Statistical analyses quantified neurophysiologic troughs by the length and depth of social-emotional events with low values and neurophysiologic peaks as the complement. Participants in the study had an average of 2.25 (SD = 3.70, Min = 0, Max = 25) neurophysiologic troughs per day and 3.28 (SD = 3.97, Min = 0, Max = 25) peaks. The number of troughs and peaks predicted daily mood with 90% accuracy using least squares regressions and machine learning models. The analysis also showed that women were more prone to low mood compared to men. Our approach demonstrates that a simple count variable derived from a commercially-available platform is a viable way to assess low mood and low energy in populations vulnerable to mood disorders. In addition, peak Immersion events, which are mood-enhancing, may be an effective measure of thriving in adults.
Signatures of selection in Angus and Hanwoo beef cattle using imputed whole genome sequence data
Authors: Nawaz Muhammad Yasir , Savegnago Rodrigo Pelicioni , Lim Dajeong , Lee Seung Hwan , Gondro Cedric
Published: August 2024

In this study, we detected signatures of selection in Hanwoo and Angus beef cattle using allele frequency and haplotype-based methods based on imputed whole genome sequence variants. Our dataset included 13,202 Angus animals with 10,057,633 imputed SNPs and 10,437 Hanwoo animals with 13,241,550 imputed SNPs. The dataset was subset down to 6,873,624 SNPs in common between the two populations to identify within population (runs of homozygosity, extended haplotype homozygosity) and between population signals of selection (allele fixation index, extended haplotype homozygosity). Assuming these selection signals were complementary to each other, they were combined into a decorrelated composite of multiple signals to identify regions under selection for each of the breeds. 27 genomic regions spanning 25.15 Mb and harboring 360 genes were identified in Angus on chromosomes 1,3, 4, 5, 6, 7, 8, 12, 13, 14, 16, 20, 21 and 28. Similarly, in Hanwoo, 59 genes and 17 genomic regions spanning 5.21 Mb on chromosomes 2, 4, 5, 6, 7, 8, 9, 10, 13, 17, 20 and 24 were identified. Apart from a small region on chromosome 13, there was no major overlap of selection signals between the two breeds reflecting their largely different selection histories, environmental challenges, breeding objectives and breed characteristics. Positional candidate genes identified in selected genomic regions in Angus have been previously associated with growth, immunity, reproductive development, feed efficiency and adaptation to environment while the candidate genes identified in Hanwoo included important genes regulating meat quality, fat deposition, cholesterol metabolism, lipid synthesis, neuronal development, and olfactory reception.
Case report: Comprehensive exploration of a novel PFKM mutation in glycogen storage disease Type VII
Authors: Chen Ying , Wang Xinyu , Ji Na , Fang Qi , Chang Xin , Liu Meirong
Published: August 2024

Glycogen Storage Disease Type VII (GSD VII) is a rare glycogen metabolism disorder resulting from mutations in the PFKM gene, inherited in an autosomal recessive manner. It is characterized by exercise intolerance, muscle cramps, myoglobinuria, compensatory hemolysis, and later onset de novo myasthenia and mild myopathy, contributing to its clinical heterogeneity and diagnostic challenges. Here, we report a rare case of a 17-year-old Chinese woman exhibiting substantial muscle weakness and compensated hemolysis. Muscle biopsies showed glycogen deposition, and blood tests showed hyperuricemia and significantly elevated creatine kinase. Whole genome sequencing (WGS) and whole exome sequencing (WES) identified two compound heterozygous mutations in the PFKM (NM_000289.6) gene: c.626G>A and c.1376G>A in exons 7 and 15, respectively. According to the clinical presentation, diagnostic examination, and WES results, the patient was finally diagnosed with GSDVII. The discovery of these two new PFKM mutations expands the genetic spectrum, and understanding the clinical manifestations of these mutations is critical to preventing diagnostic delays and timely intervention and treatment.
Elevated international normalized ratio contributes to poor prognosis in patients with traumatic lung injury
Authors: Lin Qingwei , Peng Enlan , Deng Xingping , Song Xiaomin , Zhong Lincui , He Longping , Zeng Qingbo , Song Jingchun
Published: August 2024

Objective

To investigate the pivotal determinants contributing to the adverse prognosis in patients afflicted with traumatic lung injury (TLI), with an aim to mitigate the elevated mortality rate associated with this condition.

Methods

A retrospective analysis was carried out on 106 TLI patients who were admitted to the intensive care unit of a comprehensive hospital from March 2018 to November 2022. The patients were categorized into two groups based on their 28-day outcome: the survival group (n = 88) and the death group (n = 18). Random forest model, least absolute shrinkage and selection operator (LASSO) regression and support vector machine recursive feature elimination (SVM-RFE) were utilized to pinpoint the primary factors linked to poor prognosis in TLI patients. The Receiver Operating Characteristic (ROC) curve analysis was utilized to ascertain the predictive value of INR in forecasting the prognosis of TLI patients. Based on the cut-off value of INR, patients were categorized into two groups: INR ≥ 1.36 group (n = 35) and INR < 1.36 group (n = 71). The 28-day survival rate was then compared using Kaplan–Meier analysis.

Results

Random forest model, LASSO, and SVM-RFE jointly identified International standardization ratio (INR) as a risk factor for TLI patients. The area under the ROC curve for INR in predicting the 28-day mortality of TLI patients was 0.826 (95% CI 0.733–0.938), with a cut-off value of 1.36. The 28-day mortality risk for TLI patients with an INR ≥ 1.36 was 8.5 times higher than those with an INR < 1.36.

Conclusion

Traumatic lung injury patients with elevated INR have a poor prognosis. An INR of ≥1.36 can be used as an early warning indicator for patients with traumatic lung injury.
Increased interest with the introduction of fast-track diagnostic pathway is associated with the regionally increased frequency of giant cell arteritis in Poland: a study based on POLVAS registry data
Authors: Milchert Marcin , Wójcik Krzysztof , Musiał Jacek , Masiak Anna , Majdan Maria , Jeleniewicz Radoslaw , Tłustochowicz Witold , Kur-Zalewska Joanna , Wisłowska Małgorzata , Lewandowska-Polak Anna , Makowska Joanna , Brzosko Marek
Published: August 2024

Slavic populations, such as those in Poland, are considered to have a low prevalence of giant cell arteritis (GCA), although epidemiological data are sparse. The study aimed to compare the reported frequency of GCA in various regions of Poland and analyze the differences between them. We conducted a multicenter, retrospective study of all GCA patients included in the POLVAS registry—the first large multicenter database of patients with vasculitis in Poland. The data from the POLVAS registry were compared with the reported prevalence provided by national insurers from the corresponding regions. A 10-fold increase in the diagnostic rates of GCA was observed in Poland between 2008 and 2019, reaching 8.38 per 100,000 population > 50 years old. It may be attributed to increased interest accompanied by improved diagnostic modalities with the introduction of ultrasound-based, fast-track diagnostic pathways in some centers. However, regional inequities are present, resulting in 10-fold differences (from 2.57 to 24.92) in reported prevalence between different regions. Corticosteroid (CS) monotherapy was the main stem of treatment. Further cooperation and education are needed to minimize regional inequities. This observational study suggests some potential for further increase of the recognizability of GCA and wider use of other than CS monotherapy treatment regimens. We hope that the Polish experience might be interesting and serve as some guidance for the populations where GCA is underdiagnosed.
Case report: Roxadustat overdose in an anemia patient of chronic kidney disease: insight beyond insignificant consequence
Authors: Zhang Long-Guang , Ma Xue-Juan , Li Xiang-Yang
Published: August 2024

A 71-year-old man with a 20-year history of grade 3 hypertension experienced kidney dysfunction 2 years earlier. His serum creatinine (SCr) at the time was 140 μmol/L [with estimated glomerular filtration rate (eGFR) of 43.9 ml/min per 1.73m2], for which he received irbesartan since. At initial presentation, the spot urine dipstick protein was 1+, with an albumin-to-creatinine ratio of 230 mg/g (0–30) and normal urine sediments. The SCr was 176 μmol/L (eGFR = 32.8 ml/min per 1.73m2). The hemoglobulin (Hb) level decreased from 102 to 96 g/L despite oral ferrous succinate 100 mg twice daily starting 2 months ago. Roxadustat (ROXA) 50 mg (body weight, 70 kg) three times weekly was then prescribed. Unfortunately, the patient mistakenly took the drug at 50 mg three times a day (i.e., 1,050 mg instead of the intended 150 mg per week), which was 3.5 times the recommended starting dose for non-dialysis-dependent chronic kidney disease (CKD) patients (100 mg three times weekly for body weight >60 kg) and two times the highest drug manual-recommended weekly dose (2.5 mg/kg three times weekly) approved in the country. When the attending nephrologist discovered the misuse 1 month later, the patient reported no apparent discomfort, and his home blood pressure was in the range 110–130/60–80 mmHg. Repeat blood tests showed that the Hb increased from 96 to 163 g/L and the SCr from 199 to 201 μmol/L in a month. The serum alanine transaminase (ALT) remained within the normal range (from 12 U/L at baseline to 20 U/L), while the serum total and indirect bilirubin levels were slightly elevated. ROXA was withheld immediately. In 30 days, the serum bilirubin returned to baseline, but the Hb decreased from 163 to 140 g/L, and then to 108 g/L after 3 months. On the other hand, the SCr increased from 179 to 203 μmol/L. At 9 months after the initial dosing, when the SCr increased to 256 μmol/L and the Hb decreased to 94 g/L again, ROXA 50 mg three times weekly was reinitiated uneventfully. Herein, by introducing a case who erroneously consumed twice the highest recommended dose of ROXA for a month, but had apparently no obvious discomfort or unfavorable consequence, we attempt to provide a brief overview of the mechanism of action, characteristics, drug metabolism, and side effect profile associated with this agent.
Dynamic A-to-I RNA editing during acute neuroinflammation in sepsis-associated encephalopathy
Authors: Li Yu-Ning , Liang Ya-Ping , Zhang Jing-Qian , Li Na , Wei Zhi-Yuan , Rao Yijian , Chen Jian-Huan , Jin Yun-Yun
Published: August 2024

Introduction

The activation of cerebral endothelial cells (CECs) has recently been reported to be the earliest acute neuroinflammation event in the CNS during sepsis-associated encephalopathy (SAE). Importantly, adenosine-to-inosine (A-to-I) RNA editing mediated by ADARs has been associated with SAE, yet its role in acute neuroinflammation in SAE remains unclear.

Methods

Our current study systematically analyzed A-to-I RNA editing in cerebral vessels, cerebral endothelial cells (CECs), and microglia sampled during acute neuroinflammation after treatment in a lipopolysaccharide (LPS)-induced SAE mouse model.

Results

Our results showed dynamic A-to-I RNA editing activity changes in cerebral vessels during acute neuroinflammation. Differential A-to-I RNA editing (DRE) associated with acute neuroinflammation were identified in these tissue or cells, especially missense editing events such as S367G in antizyme inhibitor 1 (Azin1) and editing events in lincRNAs such as maternally expressed gene 3 (Meg3), AW112010, and macrophage M2 polarization regulator (Mm2pr). Importantly, geranylgeranyl diphosphate synthase 1 (Ggps1) and another three genes were differentially edited across cerebral vessels, CECs, and microglia. Notably, Spearman correlation analysis also revealed dramatic time-dependent DRE during acute neuroinflammation, especially in GTP cyclohydrolase1 (Gch1) and non-coding RNA activated by DNA damage (Norad), both with the editing level positively correlated with both post-LPS treatment time and edited gene expression in cerebral vessels and CECs.

Discussion

The findings in our current study demonstrate substantial A-to-I RNA editing changes during acute neuroinflammation in SAE, underlining its potential role in the disease.
Case report: positive pitfalls of PSMA PET/CT: diagnostic challenges in degenerative bone lesions including MODIC type 1
Authors: Moukaddam Hicham , El Saheb Ghida , Omran Nadine , El Ghawi Nour , Abi Ghanem Alain , Haidar Mohamad
Published: August 2024

Prostate-specific membrane antigen (PSMA) positron emission tomography/computed tomography (PET/CT) is an imaging technique that has demonstrated high sensitivity and specificity in detecting prostate cancer and its metastasis, especially in the bones. This case describes a 60-year-old man who presented for increased prostate-specific antigen (PSA) level and underwent [68Ga]gallium-PSMA-11 PET/CT imaging for better disease assessment. 68Ga-PSMA-11 PET/CT revealed numerous radiotracer-positive lesions in both prostate lobes with associated sclerotic lesions on L4 and L5, but only L5 showed increased radiotracer avidity raising the possibility of metastasis. Magnetic Resonance Imaging (MRI) raises the possibility of aggressive MODIC type 1 lesion vs. infectious/inflammatory process. A biopsy of the radiotracer avid area was performed and showed no evidence of metastasis. The final diagnosis was aggressive MODIC type 1, in keeping with the false positive result of 68Ga-PSMA-11 PET/CT. This example demonstrates the possible limitations of 68Ga-PSMA-11 PET/CT, particularly in detecting bone metastases, and emphasizes the need for cautious interpretation and additional study to improve its diagnostic accuracy. Understanding and resolving these limitations is critical for increasing the accuracy of PSMA PET/CT in prostate cancer management.
The effect of proximity to grocery stores and the pandemic on parents’ and youths’ perceptions of eating habits in predominately African American rural communities
Authors: Williams Amanda , Newman Sharlene D.
Published: August 2024

Background

Rural communities have a disproportionately high level of childhood obesity along with high rates of food insecurity.

Objectives

To assess the eating habits of youth in predominantly African American rural communities and assess the association between proximity to a grocery store and eating habits as well as how the COVID-19 pandemic may have impacted eating habits.

Methods

203 youth and parents completed a 16-item survey. Analyses were performed to assess the effect of having a neighborhood grocery store as well as to compare responses between youth and parents.

Results

Having a neighborhood grocery store was associated with increased consumption of vegetables (F(1,122) = 41.56) and fruits (F(1,121) = 65.05), decreased consumption of chips (F(1,125) = 79.51) and a smaller percentage of overweight youth (χ2(1,125) = 5.03). Parents underestimated the effect of the COVID-19 pandemic on youth eating habits (χ2 (1,198) = 17.88).

Conclusion

Proximity to a grocery store significantly associated with eating habits and weight in the rural communities examined. Given the steady decrease in the number rural grocery stores over the past decade it is important to consider how to improve access to healthy foods in these communities.
Study the effect of Enterobacter cloacae on the gene expression, productivity, and quality traits of Curcuma longa L. Plant
Authors: Alrajeh Hind Salih , Sherif Fadia El
Published: August 2024

Overuse of artificial chemical fertilizers could be detrimental to the environment. Utilizing beneficial microorganisms as biofertilizers is a sustainable technique that promotes soil health, crop yield, and ecosystem preservation. Curcuma longa L. is utilized as a medication since it has its antibacterial, anti-microbial, and anti-tumor characteristics, which reduce inflammation and hasten wound healing. The effect of E. cloacae strain MSR1, which is common in the roots of alfalfa grown in the Al-Ahsaa region, on C. longa plants is being investigated. C. longa rhizomes were planted under greenhouse conditions after being submerged in a solution of E. cloacae strain MSR1 (OD 500) or water treatment as a control for 12 hours. After 240 days of growing, ten randomly selected plants from each treatment were collected, and the vegetative growth and yield metrics were assessed. To investigate how E. cloacae influences C. longa production and chemical composition (photosynthetic pigment, nitrogen, phosphorus, potassium, and curcuminoid), measurements were conducted as well as genes diketide-CoA and curcumin synthases genes. Our research showed that C. longa's growth and yield were favorably impacted by E. cloacae. Significant increases in the related plants' chlorophyll a,b, carotenoid, nitrogen, phosphorus, and potassium levels were likewise a reflection of the enhanced effects shown in the growth and yield parameters. Treatment with E. cloacae raised the curcuminoid's three sub-components' compositions to varying degrees: bisdemethoxycurcumin, demethoxycurcumin, and curcumin. Comparing E. cloacae treated plants to the control, high expression levels of the genes diketide-CoA and curcumin synthase-1, -2, and 3 were also found. The treatment of E. cloacae is a good biostimulant candidate for boosting growth and yield as well as raising the medicinal qualities of C. longa, according to the overall results.
A study of the psychological mechanisms of job burnout: implications of person–job fit and person–organization fit
Authors: Zeng Panpan , Hu Xiaoli
Published: August 2024

Job burnout and work pressure are pivotal concerns in human resource management and workplace mental health, profoundly impacting organizational sustainability and individual well-being. Grounded in the person–environment fit theory, this empirical study quantitatively investigates the psychological mechanisms of person–job fit and person–organization fit in job burnout, highlighting the mediating role of work pressure. To test our hypotheses, we investigated 477 employees from 63 IT enterprises around China’s Pearl River Delta region. The findings reveal that person–job fit is negatively associated with job burnout and work pressure, while work pressure positively influences job burnout, partially mediating the relationship between person–job fit and job burnout. Similarly, person–organization fit negatively affects job burnout and work pressure. However, its direct influence on job burnout is insignificant, indicating that work pressure fully mediates the relationship between person–organization fit and job burnout. These findings are consistent with the person–environment fit theory, enhancing our understanding of how individuals fit with their jobs and how organizations affect job burnout through work pressure. This study offers valuable insights for organizations seeking to mitigate burnout and promote employee well-being.
The moderating effect of perceived hope in the relationship between anxiety and posttraumatic growth during the Russian-Ukrainian war
Authors: Slezackova Alena , Malatincova Tatiana , Millova Katarina , Svetlak Miroslav , Krafft Andreas M.
Published: August 2024

Introduction

This study examines the relationships between perceived hope, posttraumatic growth, well-being, anxiety, and perceived threat of the Russian-Ukrainian War (RUW) in the Czech adult population. Drawing on the evidence of posttraumatic growth (PTG) amidst crisis, we hypothesized that perceived hope moderates the effects of perceived threat of war and anxiety on PTG.

Methods

Data were obtained from 1,000 Czech respondents via an online questionnaire ten months post-invasion. The form included measures of posttraumatic growth, perceived hope, well-being, anxiety and depression, and perceived threat of war.

Results

Our findings reveal that perceived hope acted as a moderator enhancing the positive effects of perceived threat and anxiety on PTG. However, perceived hope did not significantly moderate the direct effects of perceived threats and anxiety on well-being.

Discussion

This study highlights the significant role of hope amidst adversity and underscores its potential as a target for interventions aiming to foster PTG in populations who navigate traumatic experiences. Furthermore, it advocates for continued exploration of the factors interacting to enhance well-being and facilitate PTG in affected communities.
A bibliometric analysis of anxiety and depression among primary school students
Authors: Fu Jian Nan , Yu Wen Bing , Li Shuo Qi , Sun Wen Ze
Published: August 2024

Background

Rising anxiety and depression in primary school students adversely affect their development and academics, burdening families and schools. This trend necessitates urgent, focused research within this young demographic. This alarming trend calls for a systematic bibliometric analysis to develop effective preventative and remedial strategies

Objectives

This study aims to identify and analyze the prevailing research hotspots and emerging trends concerning anxiety and depression in primary school students, thereby furnishing a foundational reference for future academic endeavors in this area.

Methods

This study uses the Web of Science (WOS) Core Collection database as the data source, focusing on literature published between 2013 and 2023 concerning anxiety and depression in primary school students. An initial search identified 1852 articles, which were then manually screened to exclude duplicates, conferences, announcements, and unrelated literature, resulting in 1791 relevant articles. The analysis, executed on December 31, 2023, employed CiteSpace and Vosviewer tools to assess various bibliometric indicators including authorship, country, institutional affiliations, publication trends, keyword frequency, and citation analysis.

Results

The analysis revealed a corpus of 1,791 English-language articles, with a discernible upward trend in publications over the decade. The USA and China were the leading countries in this field, with 482and 272 papers, respectively. The research predominantly addresses the etiological factors of anxiety and depression, various intervention strategies, and the comorbidities associated with these conditions in the target population. Key research focuses have been identified in areas such as suicidal thoughts, bullying in schools, the impact of COVID-19, mindfulness interventions, and anxiety related to mathematics. Future research is projected to increasingly focus on the effects of mathematics anxiety on the psychological and behavioral outcomes in students.

Conclusion

This study provides a critical visual and analytical overview of the key research areas and trends in the field of anxiety and depression among primary school students. It underscores the necessity of concentrating on the underlying causes and potential interventions. Such focused research is imperative for mitigating the mental health challenges faced by young students and enhancing their educational and developmental outcomes.
Can physical activity counteract the negative effects of sedentary behavior on the physical and mental health of children and adolescents? A narrative review
Authors: Wang Kun , Li Yan , Liu Hengxu , Zhang Tingran , Luo Jiong
Published: August 2024

Background

The increase in sedentary behavior (SB) in children and adolescents is one of the major threats to global public health, and the relationship between physical activity (PA) and SB has always been a key topic.

Methods

The literature search was conducted through PubMed, Web of Science, CNKI, Wanfang, and Scopus, and 121 pieces of literature were included in this study after screening and evaluation.

Results

(1) SB caused by screen time such as mobile phones and TVs has varying degrees of negative impact on obesity, cardiovascular metabolism, skeletal muscle development, and cognitive, and psychological disorders in children and adolescents. (2) Regular physical activity could effectively prevent, offset, or improve the harm of SB to the physical and mental health of children and adolescents, mainly by reducing the incidence of obesity, and cardiovascular and metabolic risks, promoting skeletal muscle development, and improving cognitive function and mental health. (3) The mechanism of physical activity to prevent or ameliorate the harm of SB was relatively complex, mainly involving the inhibition or activation of neurobiomolecules, the improvement of blood and cell metabolic factors, and the enhancement of brain functional connectivity.

Conclusions

Children and adolescents should avoid excessive SB, and through a variety of moderate to vigorous physical activity (MVPA) to replace or intermittent SB, which could effectively prevent or improve the harm of SB to physical and mental health.
Robust control of electrohydraulic soft robots
Authors: Volchko Angella , Mitchell Shane K. , Scripps Tyler G. , Turin Zoe , Humbert J. Sean
Published: August 2024

This article introduces a model-based robust control framework for electrohydraulic soft robots. The methods presented herein exploit linear system control theory as it applies to a nonlinear soft robotic system. We employ dynamic mode decomposition with control (DMDc) to create appropriate linear models from real-world measurements. We build on the theory by developing linear models in various operational regions of the system to result in a collection of linear plants used in uncertainty analysis. To complement the uncertainty analyses, we utilize H∞ (“H Infinity”) synthesis techniques to determine an optimal controller to meet performance requirements for the nominal plant. Following this methodology, we demonstrate robust control over a multi-input multi-output (MIMO) hydraulically amplified self-healing electrostatic (HASEL)-actuated system. The simplifications in the proposed framework help address the inherent uncertainties and complexities of compliant robots, providing a flexible approach for real-time control of soft robotic systems in real-world applications.