bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving pediatric COVID-19 vaccine uptake using an mHealth tool (MoVeUP): a randomized, controlled trial
Authors: McCulloh Russell James , Darden Paul , Snowden Jessica , Ounpraseuth Songthip , Lee Jeannette , Clarke Martina , Newcomer Sophia R , Fu Linda , Hubberd DeAnn , Baldner Jaime , Garza Maryam , Kerns Ellen
Published: October 2022

Background: Coronavirus disease 2019 (COVID-19) vaccines demonstrate excellent effectiveness against infection, severe disease, and death. However, pediatric COVID-19 vaccination rates lag among individuals from rural and other medically underserved communities. The research objective of the current protocol is to determine the effectiveness of a vaccine communication mobile health (mHealth) application (app) on parental decisions to vaccinate their children against COVID-19.
Methods: Custodial parents/caregivers with ≥1 child eligible for COVID-19 vaccination who have not yet received the vaccine will be randomized to download one of two mHealth apps. The intervention app will address logistical and motivational barriers to pediatric COVID-19 vaccination. Participants will receive eight weekly push notifications followed by two monthly push notifications (cues to action) regarding vaccinating their child. Through branching logic, users will access customized content based on their locality, degree of rurality-urbanicity, primary language (English/Spanish), race/ethnicity, and child’s age to address COVID-19 vaccine knowledge and confidence gaps. The control app will provide push notifications and information on general pediatric health and infection prevention and mitigation strategies based on recommendations from the American Academy of Pediatrics (AAP) and the Centers for Disease Control and Prevention (CDC). The primary outcome is the proportion of children who complete COVID-19 vaccination series. Secondary outcomes include the proportion of children who receive ≥1 dose of COVID-19 vaccine and changes in parent/caregiver scores from baseline to immediately post-intervention on the modified WHO SAGE Vaccine Hesitancy Scale adapted for the COVID-19 vaccine.
Discussion: The COVID-19 pandemic inflicts disproportionate harm on individuals from underserved communities, including those in rural settings. Maximizing vaccine uptake in these communities will decrease infection rates, severe illness, and death. Given that most US families from these communities use smart phones, mHealth interventions hold the promise of broad uptake. Bundling multiple mHealth vaccine-uptake interventions into a single app may maximize the impact of deploying such a tool to increase COVID-19 vaccination. The new knowledge to be gained from this study will directly inform future efforts to increase COVID-19 vaccination rates across diverse settings and provide an evidentiary base for app-based vaccine communication tools that can be adapted to future vaccine-deployment efforts.
Clinical Trials Registration:
Name of the registry: clinicaltrials.gov
Trial registration number: NCT05386355
Date of registration: May 23, 2022
URL of trial registry record: https://clinicaltrials.gov/ct2/show/NCT05386355
WITHDRAWN: Tunable and High Transmission Efficiency Metal-Insulator-Metal Power Splitter and Dual Wavelength Division Multiplexer
Authors: Ghasemi Mohammad Reza , Bayati Mohammad Sajjad , Sahandabadi Sahereh
Published: October 2022

In this paper, a plasmonic power splitter and a Wavelength Division Multiplexer (WDM) based on metal-insulator-metal (MIM) surface are investigated. By using Finite Difference Time Domain (FDTD) method, the transmission spectra of the suggested devices are extracted. The simulation results demonstrate that the equal transmitted wavelengths of the two output ports can be easily tuned by changing the geometric parameters of the structure. Then, the structure geometries are modified into a WDM. Subsequently, the dependence of demultiplexing wavelengths on geometrical parameters of the structure is investigated. Besides being highly compact and efficient, having narrow-band spectra and low reflectance coefficient are the other main advantages of these devices. Therefore, the power splitter and wavelength division multiplexer presented can be of great interest in a wide range of applications from highly integrated photonic circuits to optical communication systems.
Prenatal Maternal Stress and Pediatric Asthma Across Development: Adolescent Female-Specific Vulnerability
Authors: Pike Madeline R. , Engel Melissa L. , Lipner Emily , Hammen Constance , Brennan Patricia A.
Published: October 2022

Prenatal maternal stress (PNMS) is linked to physical sequelae in offspring, including childhood asthma. This study sought to examine the roles of objective and subjective PNMS in the development of asthma at offspring ages 5 and 15. The sample included 815 mother-child dyads from the Mater Misericordiae Mothers’ Hospital-University of Queensland Study of Pregnancy. PNMS was measured via retrospective self-report during pregnancy and 3–5 days after birth. Postnatal maternal stress was measured at offspring age 5. Objective PNMS was associated with elevated asthma risk at age 5 (OR = 1.21, 95% CI = 1.00, 1.45, p = 0.05), albeit not above concurrent postnatal stress. Sex moderated the association between PNMS and asthma at age 15, controlling for postnatal stress. Sex stratified analyses revealed a positive association between objective PNMS and age 15 asthma in females, but not males. Results provide evidence that PNMS may impact asthma outcomes in adolescence.
Evidence of Unconventional Superconductivity on the Surface of the
Nodal Semimetal CaAg1−xPdxP
Authors: YANO Rikizo , Nagasaka Shota , Matsubara Naoki , Saigusa Kazushige , Tanda Tsuyoshi , Ito Seiichiro , Yamakage Ai , Okamoto Yoshihiko , Takenaka Koshi , Kashiwaya Satoshi
Published: October 2022

Surface states of topological materials provide extreme electronic states for unconventional superconducting states. CaAg1−xPdxP is an ideal candidate for a nodal-line Dirac semimetal with drumhead surface states and no additional bulk bands. Here, we report that CaAg1−xPdxP has surface states that exhibit unconventional superconductivity (SC) around 1.5 K. Extremely sharp magnetoresistance, tuned by surface-sensitive gating, determines the surface origin of the ultrahigh-mobility “electrons.” The Pd-doping elevates the Fermi level towards the surface states, and as a result, the critical temperature (Tc) is increased up to 1.7 K from 1.2 K for undoped CaAgP. Furthermore, a soft point-contact study at the surface of Pd-doped CaAgP proved the emergence of unconventional SC on the surface. We observed the bell-shaped conductance spectra, a hallmark of the unconventional SC. Ultrahigh mobility carriers derived from the surface flat bands generate a new class of unconventional SC.
Prognostic value of pre-treatment neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in patients with brain metastasis from lung cancer: A systematic review and meta-analysis.
Authors: Shao Yifeng , Zhang Wenyu , Cao Wei , Yang Bo
Published: October 2022

Background and objective:
In modern clinical medicine, the most prevalent category of cancer is lung cancer, and the brain is a routine organ of metastasis for lung cancer. Recently, researchers have evaluated hematologic indicators such as neutrophil to lymphocyte ratio (NLR) and platelet to lymphocyte ratio (PLR) and confirmed that they are valid indices for predicting outcome of lung cancer patients. However, the prognostic significance for lung cancer patients who have progressed to brain metastasis has not been clarified. In our study, a meta-analysis which focus on the association of pre-treatment NLR, PLR and overall survival (OS) in lung cancer patients with brain metastasis was performed and reported.
Methods
PubMed, Embase and CNKI databases were the scope of our search, and the search methodology was derived from PRISMA. Meta-analyses of OS were performed using random effects models due to significant heterogeneity. This study has been registered on PROSPERO (CRD42022329590).
Results
We finally included 11 articles to evaluate NLR and PLR in 1977 eligible patients. The NLR group consisted of 11 studies whose meta-analysis showed that OS was significantly shorter in high-NLR patients than low-NLR patients (pooled HR = 1.84 (95% CI: 1.47–2.31)). Five studies were included in the PLR group, and the result suggested that OS was significantly shorter in high-PLR patients than low-PLR patients (pooled HR = 1.53 (95% CI: 1.07–2.20)).
Conclusions
Meta-analysis showed that association of pre-treatment NLR, PLR and OS are statistically significant. Pre-treatment lower NLR and PLR predict better OS.
Investigation on Nonlinear Optical Properties of Symmetric and Asymmetric Double V-Shaped Potential Wells with Structural Parameters and External Electromagnetic Fields
Authors: Durmuslar Aysevil Salman
Published: October 2022

Linear, nonlinear and total optical absorption coefficients and relative refractive index changes for both symmetric and asymmetric double V-shaped quantum well configurations formed within AlxGa1-xAs/GaAs heterostructure are theoretically investigated. Responses of these coefficients to well widths, barrier widths and concentration of aluminum within the barrier as well as applied external electromagnetic fields are the subject of this study. The electronic spectra of the structures are obtained as a solution of Schrödinger equation with relevant potential and external agents in the framework of effective mass and envelope wave function approximations. The optical properties are calculated via the analytical expressions obtained by iterative solutions within compact density matrix approach. Although increasing barrier width and aluminum concentration act similar significant red shifting on the referred coefficients for both symmetric and asymmetric double V-shaped wells, the varying well widths acts differently for each configuration. Widening both wells in symmetric case moves the resonance peaks to lower energies, while the rise on only one well carries the resonance peaks to higher energies for asymmetric case. Enhancing both the electric and magnetic fields shift the resonance peaks to the blue for symmetric and also asymmetric wells. High dependency of the optical properties to the structural parameters and external electromagnetic fields as well as asymmetry of the wells is presented here in detail.
Preoperative computed tomography volumetry and graft weight estimation of left lateral segment in pediatric living donor liver transplantation
Authors: Tamulevicius Martynas , Koitka Sven , Theysohn Jens M , Oezcelik Arzu , Hoyer Dieter P , Farzaliyev Farhad , Haubold Johannes , Flaschel Nils , Nensa Felix , Treckmann Juergen , Malamutmann Eugen
Published: October 2022

Introduction: Liver volumetry based on a CT-Scan is widely used for estimating liver volume before any liver resection, especially for pediatric living donor liver transplantation (LDLT). The "One-to-one" conversion rule for liver volume to weight has been widely adopted worldwide for many years. However, most recent analyses discuss this approach.
Methods: The study retrospectively included consecutive donors undergoing left lateral hepatectomy for pediatric LDLT between December 2008 and September 2020. All donors were healthy adults who met the evaluation criteria for pediatric LDLT and underwent a preoperative contrast-enhanced CT scan. Manual segmentation of the left lateral liver lobe for volume (GV) estimation and intraoperative measurement of an actual graft weight (AGW) was performed. A relationship between estimated GV and AGW was analyzed.
Results: 94 living liver donors were included in the study. The mean AGW was approximately 283.4 ± 68.5 grams, and the mean GV was 244.9 ± 63.86 ml. There was a strong correlation between the GV and AGW (r = 0.804, p < 0.001). The Bland-Altman analysis revealed an interreader agreement of 38.0 ± 97.25 and an intraclass correlation coefficient showed an almost excellent agreement (0.840, p < 0.001). The conversion formula for calculating graft weight (GW) based on computed tomography volumetry was determined based on regression analysis: 0.88 x GV + 41.63.
Conclusion: Estimating left liver GW using "one-to-one" rule is subject to measurable variability in calculated graft weights and tends to underestimate it. Instead, a conversion formula should be used to determine donor GW more accurately.
Endotoxin Content in Neonatal Formulas, Fortification, and Lactoferrin Products: Effect on outcomes and need for measurement in enteral products and guidance on acceptable limits.
Authors: Kaufman David A. , Perks Patti H. , Greenberg Rachel G. , Jensen David
Published: October 2022

While endotoxin(lipopolysaccharide) can be harmful and contribute to morbidity and mortality with Gram-negative sepsis or necrotizing enterocolitis in preterm infants, non-toxic amounts are produced as part of the neonatal microbiome and may be present in enteral nutrition and medications administered. The United States Food and Drug Administration has given guidance for endotoxin concentration limits for intravenous medications and fluids of 5 endotoxin units/kg/hour(120 endotoxin units/kg/day), but no guidance for amounts of endotoxin in enteral products. To determine baseline exposure to infants in the neonatal intensive care unit, we examined endotoxin content of enteral formulas and fortification used for preterm infants, as well as bovine lactoferrin products. We also examined endotoxin exposure and outcomes in very low birth weight infants. Endotoxin content was measured using kinetic chromogenic limulus amebocyte lysate analysis. Daily endotoxin exposure from enteral formulas ranged between < 75 to 7110 endotoxin units/kg and from lactoferrin products from 7 to 3720 endotoxin units/kg. In examining neonatal outcomes from a bovine lactoferrin product studied at three different escalating doses, we measured endotoxin in the lactoferrin product and daily exposure was 1089(n = 10), 2178(N = 10) and 3287(N = 11) endotoxin units/kg. There were no cases of necrotizing enterocolitis or mortality in these patients. Enteral endotoxin daily exposures from lactoferrin products are similar to amounts in preterm enteral nutrition and appear safe and not associated with patient harm. Testing enteral products and establishing safety limits would improve care of high risk patients.
Evaluation of Apple (Malus domestica) Cider Vinegar and Garlic (Allium sativum) Extract as Phytogenic substitutes for growth promoting dietary antibiotics in Sexed Broiler Chickens
Authors: Chabalala oscar , Bhebhe Evison , Fushai Felix
Published: October 2022

In the poultry industry, growing concern about health risks is tightening regulations on the use of dietary antibiotic growth promoters (AGPs), raising interest in safer substitutes. The study investigated the phytogenic effects of drinking-water supplemented apple cider vinegar (ACV) and garlic extract (GAE) on broilers. The study used 390 Ross 308 broiler chicks reared in a deep litter, open house, within 2.3 m2 pen partitions. Treatments were randomly allocated in 2 (sex) x 5 (additives) factorial experiment replicated three times. Chicks started (days 1–22) on the same antibiotic starter diet, followed by grower and finisher (29–42 days) phase antibiotic-free diets plus untreated drinking water (Negative control (NC), antibiotic free diet plus ACV treated drinking water (T1), antibiotic free diet plus GAE treated drinking water (T2), antibiotic free diet plus ACV + GAE treated drinking water (T3) or antibiotic diet plus untreated drinking water (positive control (PC). Males had higher (P < 0.05) feed intake than females in both growth phases. Birds on the PC gained more (P < 0.05) weight than others. Birds on the PC consumed more feed (P < 0.05) during the finisher phase than T1, T2 and the NC. Birds on the PC had a lower (P < 0.05) grower-phase FCR than others, though with lower (P < 0.05) FCR during the finisher phase for birds on T1 and T3. Across sex, birds on the PC had the higher (P < 0.05) percent spleen weight than birds on T1. Across the sexes, birds on the PC had smaller proventriculus (P < 0.05) than on NC, T1, T2 and T3. Across the sexes, birds on the PC had lower (P < 0.05) gizzard weight than birds on the T2 and T3. Birds on the NC exhibited a lower dressing percentage (P < 0.05) than all other treatments. Meat pH was higher (P < 0.05) in males. In conclusion, in contrast to dietary antibiotics, except for increased dressing percentage, ACV and GAE did not improve broiler performance.
Design and Simulation of Reconfigurable Optical Logic Gates for Integrated Optical Circuits
Authors: Soma Savita , Gowre Sanjaykumar C , Sonth Mahesh V , Gadgay Baswaraj
Published: October 2022

The proposed work presents a new structure that can be used as reconfigurable optical logic gates. This structure is constructed in a two dimensional (2D) photonic crystals (PhCs). Logic gates like AND, NOT and NOR are realized by using the proposed structure. These optical logic gates are constructed in 6 µm * 6 µm in 2D PhCs square lattice with a lattice constant a=0.648 µm. All the gates are realized by creating structural disorders in the cross-waveguide geometries of 2D PhCs. The several performance parameters are examined using this structure and observed that proposed structure has reduced size, fast response time of 0.46ps, high bit rates of 2.14Tbits/sec and better contrast ratio of 8.6dB against the existing designs. The signal amplitude larger than 0.5 arbitrary units (a.u.) and less than 0.1 (a.u.) at output are considered as logic ‘1’ and ‘0’ respectively. The plane wave expansion (PWE) is utilised to get the band gap for this logic gate 2D PhC structure and the finite difference time domain (FDTD) technique is utilised to investigate their performance in terms of light travelling in the crystal lattice structure. The gates are implemented in third optical window at the wavelength of 1.55 µm and can be used in photonic integrated circuits for signal processing in optical communication.
Enhancement of acarbose production by rational genetic engineering and process optimization in Actinoplanes sp. SIPI12-34
Authors: Li Zhenxin , Yang Songbai , Zhang Zhengyu , Wu Yuanjie , Tang Jiawei , Wang Luoju , Chen Shaoxin
Published: October 2022

Background
Acarbose, as an alpha-glucosidase inhibitor, is widely used clinically to treat type II diabetes. In its industrial production, Actinoplanes sp. SE50/110 is used as the production strain. Lack of research on its regulatory mechanisms and unexplored gene targets are major obstacles to rational strain design. Here, transcriptome sequencing was applied to uncover more gene targets and rational genetic engineering was performed to increase acarbose production.
Results
In this study, with the help of transcriptome information, a TetR family regulator (TetR1) was identified and confirmed to have a positive effect on the synthesis of acarbose by promoting the expression of acbB and acbD. Some genes with low expression levels in the acarbose biosynthesis gene cluster were overexpressed and this resulted in a significant increase in acarbose yield. In addition, the regulation of metabolic pathways was performed to retain more glucose-1-phosphate for acarbose synthesis by weakening the glycogen synthesis pathway and strengthening the glycogen degradation pathway. Eventually, with a combination of multiple strategies and optimization of culture conditions, the yield of acarbose reached 8.04 g/L, which is the highest fermentation titer reported.
Conclusions
In our research, acarbose production was significantly improved through genetic engineering and process optimization, breaking through the production bottleneck of traditional screening and random mutagenesis.
Sb/C Composite Embedded in SiOC Buffer Matrix via Sb/MOF-Driven Dispersion Property for Novel Anode Material in Sodium-Ion Batteries
Authors: Park Jeongeun , Kim Minjun , Ku Minkyeong , Kam Dayoung , Kim Hyung-Seok , Kim Sang-Ok , Jung Hun-Gi , Chung Kyung Yoon , Choi Wonchang
Published: October 2022

Due to vast sodium reserves, sodium-ion batteries (SIBs) are more cost-efficient to produce than lithium-ion batteries. Therefore, they are actively researched as next-generation energy storage materials. Antimony (Sb) is a promising anode material for SIB owing to its high theoretical capacity (660 mA·h·g−1) and an appropriate sodiation voltage. However, due to the rapid volume change during sodium intercalation and deintercalation, cycling stability is poor, presenting a significant obstacle to the practical application of SIBs. Alleviating the Sb volume expansion throughout the charging and discharging processes is the key to the practical implementation of Sb-based anodes. Herein, Sb/C–SiOC composites are prepared using the hydrogen bonding-based adsorption properties of metal-organic frameworks (MOFs). First, Sb-MOFs are synthesized and uniformly dispersed in the SiOC precursor using the hydrogen bonding properties of Sb-MOFs. A simple pyrolysis technique is then used to produce Sb/C–SiOC composites wherein Sb/MOF-derived carbon is uniformly embedded in the SiOC matrix. The final product, the Sb/C–SiOC composites, exhibited significantly improved cycle performance, such as maintaining the initial capacity after 200 cycles by the SiOC matrix acting as a conductive buffer. Additionally, the presence of surface capacitively reactive MOF-derived mesoporous carbon and SiOC contributed to the improved rate performance. The hydrogen bond-based adsorption properties of the MOFs used in this study can be effectively applied to uniformly introduce a matrix or coating layer that relieves the volume expansion of high-capacity composite anodes, making it an effective strategy for developing alloy-based energy storage materials.
The effect of administration of A2a receptor antagonist on the activity of A2a R/CD37 pathway and induction of apoptosis in glioblastoma tumor cells in BALB/c mice
Authors: Barekat Fatemeh , Jafary Hanieh , Ghobeh Maryam
Published: October 2022

Glioblastoma is the most prevalent primary brain tumor with survival rate of about 20.5 months. Hence, investigation on the involved signaling pathways to treat the disease is urgently needed. CD73 and adenosine play key roles in tumor invasion, proliferation, angiogenesis, and chemical resistance of cancer cells. Theophylline are known as adenosine A2a receptor antagonists. Current study investigates the plausible impacts of theophylline in the mice model of glioblastoma. Materials and Methods: Initially, induction of glioblastoma tumor was performed within 10 days in male Balb/ C mice. Next, the mice were treated with theophylline for 14 days. Garcia's behavioral test was performed. Moreover, histopathological changes in brain tissue were examined using hematoxylin and eosin staining. The expression of A2a and CD73 proteins was assessed by western blotting. Additionally, the expression of VEGF was indicated by immunohistochemistry. Apoptosis was examined by the TUNEL method. Finally, serum levels of MDA and SOD were investigated using the ELISA method. Results: Garcia's behavioral test indicated a reduction in behavioral and cognitive impairments in theophylline-treated mice. Pathological results demonstrated decreased tumor size and angiogenesis in treatment group. The presence of A2a and CD73 proteins were lower in the treated mice. Moreover, immunohistochemistry investigations showed a decline in VEGF expression in brain tissue and angiogenesis in the theophylline-treated group compared to the control group. Finally, serum levels of MDA and SOD were reduced in theophylline-treated mice. Conclusion: Theophylline seem to ameliorate glioblastoma cancer by improving CD73 or adenosine signaling.
Comparison of Osteoarthritis Progression Following Tibial plateau Leveling Osteotomy performed by either locking (LCP) or dynamic compression plates (DCP) in dogs: A retrospective radiographic study of 36 stifles
Authors: G Almenshawy E. , Salem Mohamed , samy Alaa , Abouelnasr Khaled
Published: October 2022

This study was aimed to compare degree of osteoarthritic (OA) changes following tibial plateau leveling osteotomy (TPLO) performed by the use of either locking compression plates (LCP) or dynamic compression plates (DCP), following rupture of cranial cruciate ligament (CCLR) in dogs. Radiographic OA changes were evaluated in pre and post-operative radiographs of 36 stifles following TPLO using OA modified scale. Two groups were evaluated; first with CCLR operated with DCP plates, while the Second group corrected with LCP plates. Age, weight, pre- and post- operative TPA, required tibial plateau rotation, pre- and post- operative OA changes were evaluated and compared statistically using mean (m), standard deviation (SD), standard error of mean (SEM), Wilcoxon signed-rank test and t-test “paired and unpaired”. Statistical significance was set at p-value 0.05. Within 9 months following TPLO, second group stifles (DCP) were associated with increased OA mean more than first group (LCP) with highly significant difference (p-value ≤ 0.0001). In conclusion, LCP plates, as synthes clover- leaf LCP, were associated with less degree of OA changes in the long run follow up, while DCP TPLO, as Slocum plates, induced increased osteoarthritis progression in long term.
Numerical study on local contact conditions on rough surface under press hardening
Authors: Deng Liang , Pelcastre Leonardo , Mozgovoy Sergej , Lu Daixin
Published: October 2022

The primary concern of press hardening for a manufacturer is productivity, which can deteriorate owing to wear. The harsh tribological behaviours, such as increasingly frictional force and severe wear, result in blank rupture, surface scratches, and shape deviation of the formed parts, which increases the cost and time required for maintenance. Furthermore, the harsh tribological behaviours occur suddenly and develop unpredictably. To understand the mechanism behind the harsh tribological behaviours during consecutive stamping strokes, a dedicatedly tribological test that highly reproduced the press hardening conditions was conducted. A finite element (FE) simulation of the interface between the blank and the tool steel was established. The FE simulation mimicking the sliding process of the tribological test involved the real surface topography, which aimed to obtain the local contact conditions. The effects of the nominal pressure and range of the friction coefficient on the local contact conditions were studied. It was found that the local contact conditions in terms of contact pressure, contact area, and sliding distance differed from the nominal values. The present FE simulation with a rough surface explores the possible length scale of the surface topography, where the calculated parameters may be the main factors affecting wear. Furthermore, the correlation between the test variables and local contact conditions appears to be a potential method for optimising the process parameters and lubricity.
Influence of environmental conditions on lipid accumulation by the alga Halochlorella rubescens
Authors: Anbalagan Lavanya , Serri Noor Aziah , Kassim Mohd Asyraf , Merican Faradina , Convey Peter
Published: October 2022

Lipids from microalgae have been studied for their potential application in various industries, such as cosmetics, biofuel, pharmaceuticals and animal feed. This study investigates the effects of different aspects of cultivation conditions (pH, the combination of nitrogen and phosphorus sources and their concentrations, carbon dioxide (CO2) concentration and light intensity) on lipid content and formation kinetics of the alga Halochlorella rubescens in a tubular photobioreactor. The highest lipid content (38.45 ± 1.018%) and maximum biomass production (0.3468 ± 0.004 g L− 1) were achieved in nitrogen-depleted medium at pH 9, 15% CO2 and 4000 lux after optimisation using the one variable at a time (OVAT) approach. The application of Fourier Transform Infrared Spectroscopy (FTIR) confirmed the functional groups of lipids present in the wavelength range of 3012 − 2809 cm− 1 and 1745 − 1734 cm− 1. Use of the Leudeking-Piret model revealed that lipid production by H. rubescens is growth-associated under different cultivation conditions. Analysis of the lipids produced confirmed that the major fatty acids under optimum conditions were palmitic acid (C16:0), linolenic acid (C18:3n3), oleic acid (C18:1) cis and linoleic acid (C18:2) cis. The tubular photobioreactor was confirmed to be suitable for the cultivation of H. rubescens under optimal conditions, and the fatty acids produced are relevant both for biodiesel production and as an excellent source of polyunsaturated fatty acids suitable for human consumption.
Higher Education Perceived Stress and Physical Stress: Big Data Analysis.
Authors: Zhang Ruihua , Zhou Jincheng , Hai Tao , Zhang Shixue , Osamor Jude , Iwendi Marvellous GodsPraise , Shah Mohammad
Published: October 2022

Like other countries, China has suffered severe consequences as a result of the COVID-19 outbreak and pandemic. The lockdown, physical distancing, social isolation has disrupted the day-to-day activities of its citizens. The higher education sector has had to adopt state-of-the-art technologies and use online platforms to hold classes in order to engage students and ensure the continuity of education for an effective learning process. The second wave and Delta variant of the virus compelled numerous Higher Educational Institutes (HEIs) to start offline and remote work for both academic and non-academic staff; a stressful ordeal for them. Teaching has always been a stressful career path, and the stress faced by teachers has adverse consequences on the learning and performance of students. In this paper, we aim to identify and study the stress HEIs staff perceive and its impact on their physical stress and wellbeing. The resilient coping mechanism was evaluated as a moderator in the relationship between the staff and faculty’s perceived and physical stress. Using a standard survey questionnaire, 500 responses were collected. The findings revealed that the staff with the highest perceived stress also showed high symptoms of physical stress. It also indicated that resilience copers experienced reduced or very inconsequential symptoms of physical stress regardless of high perceived stress, thus validating the important moderating function of resilience in the relationship between the physical and perceived stress of the employees.
Identification of Dof Transcription Factors in the Genome of Rosa chinensis
Authors: Zhang Jinzhu , Mo Yu , Chen Shuai , Li Caihua , Fang Qingxi , Dong Jie , Mou Zhongsheng , Zhang Zheyu , Che Daidi , Chen Qingshan
Published: October 2022

The DNA binding with one finger (Dof), as an important transcription factor, plays an important role in growth and development, primary and secondary metabolism, stress resistance, and plant hormone signal transduction. However, the identification and analysis of the Dof transcription factor family in Rosa is rarely reported. In this study, 28 Rosa chinensis Dof (RcDof) members were identified, which were located on seven chromosomes. The RcDofs were divided into 12 subfamilies according to evolutionary analysis. Through motif, gene structure, and cis-acting element analyses of the 12 subfamilies, the functions of RcDofs were analyzed and predicted. Furthermore, the Dof members in R. chinensis ‘Old Blush’ and another three species (Arabidopsis thaliana, Oryza sativa, and Zea mays) were systematically analyzed. Twelve subfamilies were found in these four species and the motifs and gene structures of Dof members in each subfamily were similar, which further proves that the RcDofs analysis is accurate. Through an intra- and interspecies collinearity analysis, it was found that the collinearity between A. thaliana and R. chinensis is closer in comparison. Tissue expression analysis of RcDofs was by quantitative reverse-transcription polymerase chain reaction (PCR). Quantitative real-time PCR analysis showed expressions of the RcDofs are tissue specific. The RcDofs had higher expression in leaves, roots, and flowers than other tissues. Taken together, this study provides valuable information for future research on functional exploration of RcDof genes and molecular breeding in Rosa.
A technology of structural mathematical modelling for engineering objects under vibrational loading: Interaction forms and dynamic invariants
Authors: Eliseev A. V. , Kuznetsov N. K.
Published: October 2022

We present a system approach to evaluating dynamic forms of interactions between elements of mechanical oscillatory systems, which can be applied as design diagrams of engineering objects used for transport or technology purposes. The approach of structural mathematical modelling was used, where a mechanical oscillatory system (with the finite number of freedom degrees) is compared to the block diagram of a dynamically equivalent automatic control system. The research object was represented by a family of mechanical oscillatory systems with the finite number of freedom degrees under the action of connected force harmonic disturbances. The main research focus was on a set of dynamic states of an engineering object, which are caused by the application of common-phase external force disturbances at various frequencies and characterised by a connection coefficient. For a family of chain mechanical oscillatory systems with two degrees of freedom, a method for interpreting a set of dynamic states in the form of oriented graphs was developed. A method for constructing a population graph of dynamic states based on the frequency response of system transfer functions was developed. Within the framework of the developed interpretation, the graphs of dynamic states can be considered as peculiar invariants that persist on sets of mechanical oscillatory system parameters. Using the methodology of structural mathematical modelling, a concept of dynamic invariants was developed, according to which the totality of dynamic invariants can be used to provide a general evaluation of the variety of dynamic states and forms of dynamic interactions between the elements of mechanical oscillatory systems. The proposed concept of dynamic invariants extends the methodology of structural mathematical modelling in relation to the problems of system analysis for ensuring the safety of engineering objects for transport and technology purposes under the conditions of connected vibrational loading.
Increasing the accuracy of forecasting the electricity consumption of an industrial enterprise by machine learning methods using the selection of significant features from a time series
Authors: Sergeev N. N. , Matrenin P. V.
Published: October 2022

This study aims to improve the accuracy of forecasting the electricity consumption of an enterprise based on an analysis and preliminary processing of input data, as well as at evaluating the effect caused by feature selection on the results of various forecast models. A woodworking enterprise located in Nizhniy Novgorod was selected as a forecast object. Two types of machine learning methods, including neural network and ensemble models, were compared. An approach to selecting the most significant parameters (features) from a time series was considered in order to improve the results of the following ensemble models based on decision trees: adaptive busting (AdaBoost), Gradient Boosting and Random Forest. The most significant features of the initial time series were determined using the calculation of correlation coefficients between the values of electricity consumption in forecasted and previous hours. For the considered forecast object, the most significant features were established to be the consumed energy in hours lagging behind the forecasted hour by the multiple number of days. The schedule of repair works for woodworking machines was used as an additional feature. According to the obtained results, decision tree ensembles can surpass artificial neural networks provided that significant features are selected correctly. Thus, the smallest average error of a neural network model on a test sample comprised 7.0%, while an error of 5.5% was obtained for a Gradient Boosting ensemble model. The use of a repair schedule was demonstrated to additionally increase the forecast accuracy: for the considered ensemble models, the error reduced from 20 to 30%.
An analysis of the effect of gas turbine compressor air preheating on the technical and economic indicators of a PGU-450 unit
Authors: Skidanov M. A. , Papin V. V. , Bezuglov R. V. , Dyakonov E. M. , Efimov N. N. , Filimonov V. R.
Published: October 2022

We study the effect of preheating the air entering a gas turbine compressor using a standard closed air heating circuit system with heat supply from the heat network of the Urengoy city district power plant on the efficiency of a PGU-450 unit and this power plant as a whole. An analysis was conducted to compare the data obtained as a result of assessing the existing plant characteristics of GTE-160 gas turbines (SGT5-2000E), the adopted operating modes of air heating systems (closed air heating circuit and anti-icing system) and the effect of the operation of these systems on the specific fuel consumption of a PGU-450 unit and the Urengoy city district power plant according to the daily calculated technical and economic parameters of the power unit operation. As a result of full-scale tests carried out with the air heating system at the nominal load of a PGU-450 power unit, the optimal temperature was established to be +6.4°C. During the air heating from -5.0°C to +6.4°C, the specific consumption of the conventional fuel per 1 kWh of electricity decreased by 1.4 g. The reduced specific consumption of the conventional fuel for the supply of electric energy at an increase in the extraction ratio comprised 2.43 and 2.35 g for the equipment of the backup thermal power station and the power plant as a whole, respectively. Thus, the use of a closed air heating circuit with the unutilized network water heating leads to a positive thermal efficiency effect. The preheating of the air entering the gas turbine compressor leads to an increase in its efficiency by 0.3%. A further increase in excess of the optimum temperature leads to a decrease in the available capacity of the combined cycle plant by 3.1 MW per each degree.
Virtualization of a tube digester in alumina production
Authors: Timofeev A. A. , Danykina G. B. , Piskazhova T. V. , Kolmakova L. P.
Published: October 2022

In this work, we develop a digital twin of a tube digester and a software application automatically calculating the aluminate solution quality based on mass balance equations with the purpose of improving the quality of hydro-chemical process management at the Rusal Achinsk JSC alumina plant. A mimic diagram of the nepheline sinter leaching process was visualized using the Wonderware InTouch software package. Quick scripts were created to display the process animation. The input parameters include the solution temperature, the consumption of sinter and recycled solution, as well as the chemical composition of raw materials. The air temperature, vibrations and equipment malfunction were used as the main disturbing effects. Output parameters consisted of sludge and aluminate solution yields, power consumed by the drive and the silicon ratio of the resulting solution. Based on the mass balance of sinter and recycled solution, calculated using industrial laboratory data, an algorithm for modelling variations in the digestion process and a software application for calculating the quality of aluminate solution were developed using the InTouch built-in capabilities of scripting in its own programming language. A digital twin of a tube digester was developed on the basis of an operating unit utilized at the Rusal Achinsk JSC. It was shown that the developed software application predicts the quality of the finished product (aluminate solution) using a simple balance model under variations in both the composition of raw materials (cake and recycling solution) and the rate of fed raw materials, as well as present the results of calculations performed using a mimic diagram of the process. Thus, the developed interface can be used to simulate various technological operations performed in a tube digestor, including solution drainage, sludge discharge and variations in the inlet flows. At the same time, it becomes possible both to observe current changes in process parameters and archive plots, as well as to select the optimal composition of raw materials to obtain an aluminate solution of higher quality.
Balanced composition of multicomponent groats in conditions of the adequate nutrition concept
Authors: Zverev S. V. , Politukha O. V.
Published: October 2022

The concept of adequate nutrition envisages the compliance of a diet or a multicomponent product with multiple specific criteria, including the balance of proteins, fats and carbohydrates (P: F: C), biological value of protein, the presence of necessary vitamins and minerals in the composition and so on. Adherence to the theory of adequate nutrition is a multicriterion task, which solution in the full measure is not considered possible. The paper examines specific indicators and makes an attempt to construct multicomponent groats that meet two main criteria — protein completeness and balance (P: C). The value of the criteria is based on the recommendations of the Federal Hygienic and Epidemiological Center of the RF. Complete protein corresponds to the minimal essential amino acid (EAA) score not lower than one. The B: C ratio, in general, depends on a human gender, age and physical load. The B: C was taken as averaged for men of different ages and different physical loads. In this study, traditional groats (fine-ground barley, rice, maize, millet), groats from grains of leguminous crops (chickpea, lentil, kidney bean, pea) and oil seeds (flax, hemp) were examined as ingredients. Using the computational method and data on the nutritional value of food products from several databases, the authors developed recipes of two- and threecomponent groats that meet the indicated criteria. The proportion of leguminous and oil crops in the obtained mixtures is 17–45%, which can affect taste of porridge. During the study, tasting of fine-ground barley porridge with addition of chickpea and lentil upon legume addition at a level of 10–35% was carried out. The porridge taste remained to be pleasant even at the maximum level of legume addition. Off-flavor typical of legumes was absent.
Essential renormalisation group
Authors: Baldazzi Alessio , Ben Ali Zinati Riccardo , Falls Kevin
Published: October 2022

We propose a novel scheme for the exact renormalisation group
motivated by the desire of reducing the complexity of practical
computations. The key idea is to specify renormalisation conditions for
all inessential couplings, leaving us with the task of computing only
the flow of the essential ones. To achieve this aim, we utilise a
renormalisation group equation for the effective average action which
incorporates general non-linear field reparameterisations. A prominent
feature of the scheme is that, apart from the renormalisation of the
mass, the propagator evaluated at any constant value of the field
maintains its unrenormalised form. Conceptually, the simplifications can
be understood as providing a description based only on quantities that
enter expressions for physical observables since the redundant,
non-physical content is automatically disregarded. To exemplify the
scheme’s utility, we investigate the Wilson-Fisher fixed point in three
dimensions at order two in the derivative expansion. In this case, the
scheme removes all order \partial^2∂2
operators apart from the canonical term. Further simplifications occur
at higher orders in the derivative expansion. Although we concentrate on
a minimal scheme that reduces the complexity of computations, we propose
more general schemes where inessential couplings can be tuned to
optimise a given approximation. We further discuss the applicability of
the scheme to a broad range of physical theories.
Validación de un instrumento para la medición de la sostenibilidad empresarial en pequeñas y medianas empresas
Authors:   Universidad Católica Luis Amigó, Osorio Atehortúa Ubeimar Aurelio , Martínez Gómez Jormaris ,   Universidad Católica Luis Amigó, Quintero Arango Luis Fernando ,   Universidad Católica Luis Amigó, Lamy Clemente ,   Etipyme Colombia S.A.S, Obregón Gómez Elisa Cristina ,   Etipyme Colombia S.A.S, Aristizábal Velásquez Mónica Eliana ,   Universidad Católica Luis Amigó
Published: October 2022

Este libro presenta los resultados de la investigación “Sostenibilidad en mipymes, un modelo de evaluación a nivel latinoamericano”, financiada por la Universidad Católica Luis Amigó y la empresa Etipyme S.A.S., cuyo desarrollo permitió diseñar un instrumento de diagnóstico inicial de sostenibilidad desde la particularidad de cada organización, brindando información útil que facilita la toma de decisiones en lo relacionado con lo ambiental, social y económico.
Estrategias de intervención y posvención del comportamiento suicida
Authors:   Universidad Católica Luis Amigó, García Peña John Jairo
Published: October 2022

Este segundo libro enmarcado en la investigación sobre el comportamiento suicida, contiene estrategias de intervención y de posvención, tanto a nivel de la prevención como ante la ocurrencia de un evento. Es el resultado reflexivo de un trabajo, ejecutado durante 4 años, financiado por la Universidad Católica Luis Amigó, y llevado a cabo en ocho localidades de Antioquia de forma presencial y en algunos países de la región de manera virtual; en donde se ha prestado asesoría y acompañamiento técnico con el propósito de fortalecer las competencias institucionales de estas localidades en lo referente al suicidio; el libro, presenta este proceso de investigación acción. Esperamos que su contenido, sea de utilidad para toda persona o institución interesados en saber cómo afrontar y contener esta problemática humana.
Evaluation of the efficacy and safety of remdesivir in hospitalized patients with a new coronavirus infection COVID-19: data from a Russian university clinic
Authors: Yanushevich O. O. , Maev I. V. , Krikheli N. I. , Levchenko O. V. , Andreev D. N. , Sokolov P. S. , Fomenko A. K. , Devkota M. K. , Andreev N. G. , Zaborovsky A. V. , Shefer D. I.
Published: October 2022

Introduction. The use of remdesivir in patients with the new coronavirus infection COVID-19 is known to improve the prognosis of the disease. But there is not enough data on efficacy and safety of remdesivir use in patients from Russia. Aim. To evaluate the efficacy and safety of remdesivir in patients with COVID-19.Materials and methods. A comparative prospective study was conducted in two parallel groups. The study enrolled 300 patients diagnosed with COVID-19 (grade 1–3 severe pneumonia according to CT scan), who were divided into two groups (n = 150 in each) according to the prescription of remdesivir. Treatment efficacy was assessed by recording cases of disease progression and adverse outcomes. The safety of therapy was assessed by hepatotoxicity and nephrotoxicity.Results. Patients receiving remdesivir were significantly less likely to be transferred to the intensive care unit (OR 0.3884, 95% CI: 0.1645–0.9175) and to be on artificial ventilation (OR 0.3830, 95% CI: 0.1539–0.9527). Treatment with remdesivir had no significant effect on mortality (OR 0.4932, 95% CI: 0.08897–2.7346) and complications (OR 0.4391, 95% CI: 0.1623–1.1879), including acute respiratory distress syndrome (OR 0.3919, 95% CI: 0.07483–2.0524). The duration of hospitalization was significantly shorter in group 1 patients – 12.2533 days (95% CI: 11.4101–13.0966) compared to group 2 – 14.5267 days (95% CI: 13.5125–15.5408). Hepatotoxicity with remdesivir (OR 1.5376, 95% CI: 0.8035–2.9426), nephrotoxicity (OR 1.6338, 95% CI: 0.522–5.1141) were noted, but no statistically significant difference was found (p > 0.05).Conclusions. The addition of remdesivir to the basic regimen of patients with new coronavirus infection COVID-19 improved the course of the disease, reducing the risks of patients being transferred to the intensive care unit and of receiving artificial ventilation.