bluuebunny/crossref_metadata_2025 huggingface dataset:
Premature Pubarche: Time to Revise the Diagnostic Approach?
Authors: Baronio Federico , Marzatico Alice , De Iasio Rosaria , Ortolano Rita , Fanolla Antonio , Radetti Giorgio , Balsamo Antonio , Pession Andrea , Cassio Alessandra
Published: March 2023

Premature pubarche (PP) could represent the first manifestation of non-classic congenital adrenal hyperplasia caused by 21 hydroxylase deficiency (NC21OHD) (10–30% of cases). In the last 20 years, the necessity of performing an ACTH test to diagnose NC21OHD in all cases with PP has been questioned, with conflicting results. This study aims to retrospectively evaluate the predictive value of the basal androgens, 17-OHP levels, and auxological features in suggesting the presence of NC21OHD and, thus, the need for a standard ACTH test to confirm the diagnosis. In all, 111 consecutive patients (87 females) with PP and advanced bone age underwent an ACTH test. Of these, 6/111 cases (1 male) were diagnosed with NC21OHD. The mean baseline 17 hydroxyprogesterone (17-OHP), dehydroepiandrosterone (DHEA), dehydroepiandrosterone sulfate (DHEA-S), delta 4 androstenedione (Δ4A), and testosterone serum levels were higher in NC21OHD patients than in the others (p < 0.05). We found three predictive features for NC21OHD: basal 17 OHP of >200 ng/mL, bone age advance of >2 years, and DHEA-S levels of >228 ng/mL with sensitivity and specificity of 83.3% and 97.1%, 83.3% and 65.7%, and 83.3% and 96.2%, respectively. Our data confirm that the prevalence of NC21OHD is low among patients with PP. Serum 17-OHP of >200 ng/mL could be helpful to decide, in most cases, which patients should undergo the ACTH test. Bone age advance represented an inadequately specific predictive marker of NC21OHD.
Myelofibrosis and Survival Prognostic Models: A Journey between Past and Future
Authors: Duminuco Andrea , Nardo Antonella , Giuffrida Gaetano , Leotta Salvatore , Markovic Uros , Giallongo Cesarina , Tibullo Daniele , Romano Alessandra , Di Raimondo Francesco , Palumbo Giuseppe A.
Published: March 2023

Among the myeloproliferative diseases, myelofibrosis is a widely heterogeneous entity characterized by a highly variable prognosis. In this context, several prognostic models have been proposed to categorize these patients appropriately. Identifying who deserves more invasive treatments, such as bone marrow transplantation, is a critical clinical need. Age, complete blood count (above all, hemoglobin value), constitutional symptoms, driver mutations, and blast cells have always represented the milestones of the leading models still used worldwide (IPSS, DIPSS, MYSEC-PM). Recently, the advent of new diagnostic techniques (among all, next-generation sequencing) and the extensive use of JAK inhibitor drugs have allowed the development and validation of new models (MIPSS-70 and version 2.0, GIPSS, RR6), which are continuously updated. Finally, the new frontier of artificial intelligence promises to build models capable of drawing an overall survival perspective for each patient. This review aims to collect and summarize the existing standard prognostic models in myelofibrosis and examine the setting where each of these finds its best application.
The Challenges and Hopes in Treating Patients with NOA
Authors: Friedler Shevach
Published: March 2023

Infertility due to the male factor occurs in no less than 50% of investigated couples [...]
Altered Gut Microbic Flora and Haemorrhoids: Could They Have a Possible Relationship?
Authors: Palumbo Vincenzo Davide , Tutino Roberta , Messina Marianna , Santarelli Mauro , Nigro Casimiro , Lo Secco Giacomo , Piceni Chiara , Montanari Elena , Barletta Gabriele , Venturelli Paolina , Geraci Girolamo , Bonventre Sebastiano , Lo Monte Attilio Ignazio
Published: March 2023

To date, the exact pathophysiology of haemorrhoids is poorly understood. The different philosophies on haemorrhoids aetiology may lead to different approaches of treatment. A pathogenic theory involving a correlation between altered anal canal microflora, local inflammation, and muscular dyssynergia is proposed through an extensive review of the literature. Since the middle of the twentieth century, three main theories exist: (1) the varicose vein theory, (2) the vascular hyperplasia theory, and (3) the concept of a sliding anal lining. These phenomena determine changes in the connective tissue (linked to inflammation), including loss of organization, muscular hypertrophy, fragmentation of the anal subepithelial muscle and the elastin component, and vascular changes, including abnormal venous dilatation and vascular thrombosis. Recent studies have reported a possible involvement of gut microbiota in gut motility alteration. Furthermore, dysbiosis seems to represent the leading cause of bowel mucosa inflammation in any intestinal district. The alteration of the gut microbioma in the anorectal district could be responsible for haemorrhoids and other anorectal disorders. A deeper knowledge of the gut microbiota in anorectal disorders lays the basis for unveiling the roles of these various gut microbiota components in anorectal disorder pathogenesis and being conductive to instructing future therapeutics. The therapeutic strategy of antibiotics, prebiotics, probiotics, and fecal microbiota transplantation will benefit the effective application of precision microbiome manipulation in anorectal disorders.
Gender-Related Discrepancies in Short-Term Outcomes in Patients Undergoing Off-Pump Coronary Artery Bypass Grafting Surgery
Authors: Krasivskyi Ihor , Djordjevic Ilija , Ivanov Borko , Eghbalzadeh Kaveh , Großmann Clara , Reichert Stefan , Radwan Medhat , Sandoval Boburg Rodrigo , Sabashnikov Anton , Schlensak Christian , Wahlers Thorsten , Rustenbach Christian Jörg
Published: March 2023

The sex differences in patients undergoing off-pump coronary artery bypass grafting (OPCAB) surgery are still unclear. Our aim was to investigate the impact of gender on short-term outcomes in males and females after off-pump bypass procedures. Our research was designed as a double-center retrospective analysis. Generally, 343 patients (men (n = 255) and women (n = 88)) who underwent an OPCAB procedure were included in our study. To provide a statistical analysis of unequal cohorts, we created a propensity score-based matching (PSM) analysis (men, n = 61; women, n = 61). The primary endpoint was all-cause in-hospital mortality. Dialysis, transient ischemic attack (TIA), low cardiac output syndrome (LCOS), reoperation due to postoperative bleeding, wound infection and duration of hospital stay were secondary outcomes in our analysis. No significant differences were detected within the male and female groups regarding age (p = 0.116), BMI (p = 0.221), diabetes (p = 0.853), cardiogenic shock (0.256), STEMI (p = 0.283), NSTEMI (p = 0.555) and dialysis (p = 0.496). Males underwent significantly more frequently (p = 0.005) total-arterial revascularization with T-graft technique (p = 0.005) than females. In contrast, temporary pacer use was significantly higher (p = 0.022) in females compared to males. The in-hospital mortality rate was not significantly higher (p = 0.496) in the female group compared to the male group. Likewise, secondary outcomes did not differ significantly between the non-adjusted and the adjusted groups. Based on our findings, gender has no impact on short-term outcomes after OPCAB surgery.
Assessment of Low-Level Air Pollution and Cardiovascular Incidence in Gdansk, Poland: Time-Series Cross-Sectional Analysis
Authors: Czernych Radosław , Badyda Artur , Kozera Grzegorz , Zagożdżon Paweł
Published: March 2023

(1) Background: More than 1.8 million people in the European Union die every year as a result of CVD, accounting for 36% of all deaths with a large proportion being premature (before the age of 65). There are more than 300 different risk factors of CVD, known and air pollution is one of them. The aim of this study was to investigate whether daily cardiovascular mortality was associated with air pollutants and meteorological conditions in an urban environment with a low level of air pollution. (2) Methods: Data on daily incidence of strokes and myocardial infarctions in the city of Gdansk were obtained from the National Health Fund (NHF) and covered the period from 1 January 2014 to 31 December 2018. Data on the level of pollution, i.e., SO2, NO, NO2, NOx, CO, PM10, PM2.5, CO2, O3 and meteorological conditions came from the foundation: Agency of Regional Air Quality Monitoring in the Gdańsk metropolitan area (ARMAG). Using these data, we calculated mean values with standard deviation (SD) and derived the minimum and maximum values and interquartile range (IQR). Time series regression with Poisson distribution was used in statistical analysis. (4) Results: Stroke incidence is significantly affected by an increase in concentrations of NO, NO2 and NOx with RRs equal to 1.019 (95%CI: 1.001–1.036), 1.036 (95%CI: 1.008–1.064) and 1.017 (95%CI: 1.000–1.034) for every increase in IQR by 14.12, 14.62 and 22.62 μg/m3, respectively. Similarly, myocardial infarction incidence is significantly affected by an increase in concentrations of NO, NO2 and NOx with RRs equal to 1.030 (95%CI: 1.011–1.048), 1.053 (95%CI: 1.024–1.082) and 1.027 (95%CI: 1.010–1.045) for every increase in IQR by 14.12, 14.62 and 22.62 μg/m3, respectively. Both PM10 and PM2.5 were positively associated with myocardial infarction incidence. (5) Conclusions: In this time-series cross-sectional study, we found strong evidence that support the hypothesis that transient elevations in ambient PM2.5, PM10, NO2, SO2 and CO are associated with higher relative risk of ischemic stroke and myocardial infarction incidents.
Rifaximin Improves Liver Functional Reserve by Regulating Systemic Inflammation
Authors: Kitsugi Kensuke , Kawata Kazuhito , Noritake Hidenao , Chida Takeshi , Ohta Kazuyoshi , Ito Jun , Takatori Shingo , Yamashita Maho , Hanaoka Tomohiko , Umemura Masahiro , Matsumoto Moe , Suda Takafumi
Published: March 2023

Rifaximin, a non-absorbable antibiotic, has been demonstrated to be effective against hepatic encephalopathy (HE); however, its efficacy on liver functional reserve remains unknown. Here, we evaluated the efficacy of rifaximin on the liver functional reserve and serological inflammation-based markers in patients with cirrhosis. A retrospective study was conducted on patients who received rifaximin for more than three months at our hospital between November 2016 and October 2021. The recurrence and grade of HE, serological ammonia levels, Child–Pugh score (CPS), and serological inflammation-based markers such as the neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), platelet–lymphocyte ratio (PLR), C-reactive protein (CRP), and CRP to albumin ratio (CAR) were evaluated. The correlations between serological inflammation-based markers and liver functional reserve were evaluated. HE grades, serum ammonia levels, and inflammation-based markers significantly improved at three months compared with those at baseline. Patients with improved albumin levels showed significantly higher CRP improvement rates at both 3 and 12 months. Patients with an improvement in CAR at 3 months demonstrated a significant improvement in CPS at 12 months. Rifaximin improved the liver functional reserve in patients with cirrhosis. Improvements in inflammation-based markers, particularly CRP and albumin, may be involved in this process.
Impact of Sarcopenia on Survival in Patients Treated with FOLFIRINOX in a First-Line Setting for Metastatic Pancreatic Carcinoma
Authors: Lellouche Lisa , Barat Maxime , Pellat Anna , Leroux Juliette , Corre Felix , Hallit Rachel , Assaf Antoine , Brezault Catherine , Dhooge Marion , Soyer Philippe , Coriat Romain
Published: March 2023

Sarcopenia, defined as decreased muscle mass and strength, can be evaluated by a computed tomography (CT) examination and might be associated with reduced survival in patients with carcinoma. The prognosis of patients with metastatic pancreatic carcinoma is poor. The FOLFIRINOX (a combination of 5-fluorouracil, irinotecan, and oxaliplatin) chemotherapy regimen is a validated first-line treatment option. We investigated the impact of sarcopenia on overall survival (OS) and progression-free survival (PFS) in patients with metastatic pancreatic carcinoma. Clinical data and CT examinations of patients treated with FOLFIRINOX were retrospectively reviewed. Sarcopenia was estimated using baseline CT examinations. Seventy-five patients were included. Forty-three (57.3%) were classified as sarcopenic. The median OS of non-sarcopenic and sarcopenic patients were 15.6 and 14.1 months, respectively (p = 0.36). The median PFS was 10.3 in non-sarcopenic patients and 9.3 in sarcopenic patients (p = 0.83). No differences in toxicity of FOLFIRINOX were observed. There was a trend towards a higher probability of short-term death (within 4 months of diagnosis) in sarcopenic patients. In this study, the detection of sarcopenia failed to predict a longer OS or PFS in selected patients deemed eligible by a physician for triplet chemotherapy and receiving the FOLFIRINOX regimen in a first-line setting, confirming the major importance of a comprehensive patient assessment by physicians in selecting the best treatment option.
The Necessity of Implant Removal after Fixation of Thoracolumbar Burst Fractures—A Systematic Review
Authors: Wang Xing , Wu Xiang-Dong , Zhang Yanbin , Zhu Zhenglin , Jiang Jile , Li Guanqing , Liu Jiacheng , Shao Jiashen , Sun Yuqing
Published: March 2023

Background: Thoracolumbar burst fractures are a common traumatic vertebral fracture in the spine, and pedicle screw fixation has been widely performed as a safe and effective procedure. However, after the stabilization of the thoracolumbar burst fractures, whether or not to remove the pedicle screw implant remains controversial. This review aimed to assess the benefits and risks of pedicle screw instrument removal after fixation of thoracolumbar burst fractures. Methods: Data sources, including PubMed, EMBASE, Cochrane Library, Web of Science, Google Scholar, and Clinical trials.gov, were comprehensively searched. All types of human studies that reported the benefits and risks of implant removal after thoracolumbar burst fractures, were selected for inclusion. Clinical outcomes after implant removal were collected for further evaluation. Results: A total of 4051 papers were retrieved, of which 35 studies were eligible for inclusion in the review, including four case reports, four case series, and 27 observational studies. The possible risks of pedicle screw removal after fixation of thoracolumbar burst fractures include the progression of the kyphotic deformity and surgical complications (e.g., surgical site infection, neurovascular injury, worsening pain, revision surgery), while the potential benefits of pedicle screw removal mainly include improved segmental range of motion and alleviated pain and disability. Therefore, the potential benefits and possible risks should be weighed to support patient-specific clinical decision-making about the removal of pedicle screws after the successful fusion of thoracolumbar burst fractures. Conclusions: There was conflicting evidence regarding the benefits and harms of implant removal after successful fixation of thoracolumbar burst fractures, and the current literature does not support the general recommendation for removal of the pedicle screw instruments, which may expose the patients to unnecessary complications and costs. Both surgeons and patients should be aware of the indications and have appropriate expectations of the benefits and risks of implant removal. The decision to remove the implant or not should be made individually and cautiously by the surgeon in consultation with the patient. Further studies are warranted to clarify this issue. Level of evidence: level 1.
The Firmicutes/Bacteroidetes Ratio as a Risk Factor of Breast Cancer
Authors: An Jeongshin , Kwon Hyungju , Kim Young Ju
Published: March 2023

The gut microbiome can reflect the health condition of the entire body. Firmicutes and Bacteroidetes, the major phyla of the colon, can influence diseases related to obesity which are also risk factors for breast cancer. Therefore, the Firmicutes/Bacteroidetes (F/B) ratio was analyzed in patients with breast cancer. Bacterial extracellular vesicles were extracted from the serum of patients with breast cancer and healthy controls. Phyla Firmicutes and Bacteroidetes were analyzed using microbiome sequencing. Prognostic factors for breast cancer and serological test results were analyzed for correlations with the F/B ratio. The F/B ratio was three times lower in patients with breast cancer than in healthy controls. In addition, the risk factor for breast cancer, such as fasting serum glucose, was found to be related to the F/B ratio. The F/B ratio can be used as a risk factor of breast cancer and as a clue to explain underlying mechanisms affecting the development of breast cancer.
Inferior Vena Cava Ultrasonography for Volume Status Evaluation: An Intriguing Promise Never Fulfilled
Authors: Di Nicolò Pierpaolo , Tavazzi Guido , Nannoni Luca , Corradi Francesco
Published: March 2023

The correct determination of volume status is a fundamental component of clinical evaluation as both hypovolaemia (with hypoperfusion) and hypervolaemia (with fluid overload) increase morbidity and mortality in critically ill patients. As inferior vena cava (IVC) accounts for two-thirds of systemic venous return, it has been proposed as a marker of volaemic status by indirect assessment of central venous pressure or fluid responsiveness. Although ultrasonographic evaluation of IVC is relatively easy to perform, correct interpretation of the results may not be that simple and multiple pitfalls hamper its wider application in the clinical setting. In the present review, the basic elements of the pathophysiology of IVC behaviour, potential applications and limitations of its evaluation are discussed.
Predictive Factors of Local Recurrence after Colorectal Cancer Liver Metastases Thermal Ablation
Authors: Odet Julien , Pellegrinelli Julie , Varbedian Olivier , Truntzer Caroline , Midulla Marco , Ghiringhelli François , Orry David
Published: March 2023

Background: Identify risk factors for local recurrence (LR) after radiofrequency (RFA) and microwave (MWA) thermoablations (TA) of colorectal cancer liver metastases (CCLM). Methods: Uni- (Pearson’s Chi2 test, Fisher’s exact test, Wilcoxon test) and multivariate analyses (LASSO logistic regressions) of every patient treated with MWA or RFA (percutaneously and surgically) from January 2015 to April 2021 in Centre Georges François Leclerc in Dijon, France. Results: Fifty-four patients were treated with TA for 177 CCLM (159 surgically, 18 percutaneously). LR rate was 17.5% of treated lesions. Univariate analyses by lesion showed factors associated with LR: sizes of the lesion (OR = 1.14), size of nearby vessel (OR = 1.27), treatment of a previous TA site LR (OR = 5.03), and non-ovoid TA site shape (OR = 4.25). Multivariate analyses showed that the size of the nearby vessel (OR = 1.17) and the lesion (OR = 1.09) remained significant risk factors of LR. Conclusions: The size of lesions to treat and vessel proximity are LR risk factors that need to be considered when making the decision of thermoablative treatments. TA of an LR on a previous TA site should be reserved to specific situations, as there is an important risk of another LR. An additional TA procedure can be discussed when TA site shape is non-ovoid on control imaging, given the risk of LR.
A Real-Time Registration Algorithm of UAV Aerial Images Based on Feature Matching
Authors: Liu Zhiwen , Xu Gen , Xiao Jiangjian , Yang Jingxiang , Wang Ziyang , Cheng Siyuan
Published: March 2023

This study aimed to achieve the accurate and real-time geographic positioning of UAV aerial image targets. We verified a method of registering UAV camera images on a map (with the geographic location) through feature matching. The UAV is usually in rapid motion and involves changes in the camera head, and the map is high-resolution and has sparse features. These reasons make it difficult for the current feature-matching algorithm to accurately register the two (camera image and map) in real time, meaning that there will be a large number of mismatches. To solve this problem, we used the SuperGlue algorithm, which has a better performance, to match the features. The layer and block strategy, combined with the prior data of the UAV, was introduced to improve the accuracy and speed of feature matching, and the matching information obtained between frames was introduced to solve the problem of uneven registration. Here, we propose the concept of updating map features with UAV image features to enhance the robustness and applicability of UAV aerial image and map registration. After numerous experiments, it was proved that the proposed method is feasible and can adapt to the changes in the camera head, environment, etc. The UAV aerial image is stably and accurately registered on the map, and the frame rate reaches 12 frames per second, which provides a basis for the geo-positioning of UAV aerial image targets.
Disentangling Population Level Differences in Juvenile Migration Phenology for Three Species of Salmon on the Yukon River
Authors: Miller Katharine B. , Weiss Courtney M.
Published: March 2023

Migration phenology influences many important ecological processes. For juvenile Pacific salmon, the timing of the seaward migration from fresh to marine waters is linked to early marine survival and adult returns. Seaward migration phenology is determined by interactions between the intrinsic attributes of individual species and environmental factors that are acting upon them. Temperature and discharge are two factors of the freshwater environment that have been shown to influence intra- and interannual variation in juvenile salmon phenology, but these factors may affect the migrations of sympatric species differently. Understanding how variations in phenology change with environmental heterogeneity is a critical first step in evaluating how the future climate may affect salmon. This is especially crucial for high-latitude rivers, where the pace of climate change is nearly twice as rapid as it is for more temperate areas. This research investigates the influence of river conditions on the seaward migration phenology of Chinook, chum, and coho salmon in the Yukon River. The results identified species-specific differences in the factors affecting migration duration, concentration, and skew and provide a starting point for a more detailed examination of how phenological variability may affect the temporal matching of juvenile salmon with biological resources and environmental conditions for optimal survival.
The Bryozoan Margaretta cereoides as Habitat-Former in the Coralligenous of Marzamemi (SE Sicily, Mediterranean Sea)
Authors: Rosso Antonietta , Donato Gemma , Sanfilippo Rossana , Serio Donatella , Sciuto Francesco , D’Alpa Francesco , Bracchi Valentina Alice , Negri Mauro Pietro , Basso Daniela
Published: March 2023

Although several bryozoans are considered habitat-former species, allowing colonisation by epibionts and promoting biodiversity, studies dealt so far with only some, usually constructional, species. In this context, the present study focuses on the epibiosis found on the erect mineralised but flexible species Margaretta cereoides, contributing with some macroalgae to the canopy formation on a coralligenous build-up collected at 36.7 m depth offshore Marzamemi (Ionian Sea, Mediterranean) in the frame of the project CRESCIBLUREEF. Focusing on bryozoans and serpulids we documented high diversity (species richness) on the investigated substrata (M. cereoides, Flabellia petiolata, Peyssonnelia rubra, Osmundaria volubilis and all other fleshy algae including Phyllophora crispa). Diversity, total number of colonies/specimens hosted, and number of colonies/specimens per cm2 are higher on M. cereoides than on algae, possibly in relation with the morphology, robustness and persistence of the surface offered by the bryozoan contrasting with the flexible and ephemeral nature of most algae, often provided with chemical defenses. Bryozoan and even more serpulid epibiont diversity on M. cereoides is also higher than those reported for studied species in the Mediterranean and for Flustra foliacea from North Europe.
Research on a Novel Combined Cooling and Power Scheme for LNG-Powered Ship
Authors: Xiao Xiu , Xu Xiaoqing , Wang Zhe , Liu Chenxi , He Ying
Published: March 2023

Cold energy recovery in LNG-powered vessels can not only improve the utilization efficiency of energy, but also benefit environmental protection. This paper put forward a new cascade scheme for utilizing flue gas waste heat and LNG cold energy comprehensively. The scheme was integrated by a dual organic Rankine circulation system (ORC), a high- and low-temperature cold storage system (TCS), an air conditioning system (ACS) and a seawater desalination system (SDS). The working medium of the dual ORC system was firstly determined by considering exergy efficiency and economic index simultaneously. On this basis, the adaptive weighted particle swarm optimization algorithm was employed to enhance thermodynamic performance of the scheme with the net output power as the optimization objective. The maximum net power and annual net interest rate can reach 725.78 kW and $115,300, respectively. Furthermore, the economic benefit of the scheme was analyzed by referring to the running track and the operation condition of the target ship. The results showed that the proposed scheme is a potential large-scale cryogenic technology and can bring considerable economic benefits to ship navigation.
A Biologist’s Guide to the Galaxy: Leveraging Artificial Intelligence and Very High-Resolution Satellite Imagery to Monitor Marine Mammals from Space
Authors: Khan Christin B. , Goetz Kimberly T. , Cubaynes Hannah C. , Robinson Caleb , Murnane Erin , Aldrich Tyler , Sackett Meredith , Clarke Penny J. , LaRue Michelle A. , White Timothy , Leonard Kathleen , Ortiz Anthony , Lavista Ferres Juan M.
Published: March 2023

Monitoring marine mammals is of broad interest to governments and individuals around the globe. Very high-resolution (VHR) satellites hold the promise of reaching remote and challenging locations to fill gaps in our knowledge of marine mammal distribution. The time has come to create an operational platform that leverages the increased resolution of satellite imagery, proof-of-concept research, advances in cloud computing, and machine learning to monitor the world’s oceans. The Geospatial Artificial Intelligence for Animals (GAIA) initiative was formed to address this challenge with collaborative innovation from government agencies, academia, and the private sector. In this paper, we share lessons learned, challenges faced, and our vision for how VHR satellite imagery can enhance our understanding of cetacean distribution in the future.
Influence of Soil Plug on the Seismic Response of Bucket Foundations in Liquefiable Seabed
Authors: Qu Xue-Qian , Wang Rui , Zhang Jian-Min , He Ben
Published: March 2023

The suction installation process for bucket foundations for offshore wind turbines (OWTs) can cause the formation of soil plug within the bucket, which can affect the seismic performance of the OWT. Therefore, it is important to evaluate the influence of soil plug on the seismic performance of OWT on bucket foundations. In this study, a comprehensive set of high-fidelity solid–fluid coupled dynamic numerical simulations are conducted to analyze the seismic response of bucket foundations with a focus on the influence of soil plug and its potential mitigation. The influence of different bucket models, seabed soil densities, seabed inclination and reinforcement types, as well as soil plug removal techniques, are investigated. The results clearly show that the existence of soil plug has a significant unfavorable influence on the seismic performance of OWT on bucket foundations, especially for wide bucket foundations in mildly inclined seabeds, and should be considered in seismic design. Reinforcement methods, such as the application of an inner compartments, outer wings and inner pile, can improve the seismic performance of OWT on bucket foundations, with the application of an inner compartment being the most effective. Soil plug removal can alleviate the negative influence of soil plug, and should be adopted when possible.
Antifouling Potential of Diadema setosum and Sonneratia lanceolata Extracts for Marine Applications
Authors: Mohd Ramzi Mujahidah , Rahman Nor Izzati Abd , Rawi Nurul Najihah , Bhubalan Kesaven , Ariffin Fazilah , Mazlan Noor Wini , Saidin Jasnizat , Danish-Daniel Muhd , Siong Julius Yong Fu , Bakar Kamariah , Mohd Zin Nor Atikah , Azemi Ahmad Khusairi , Ismail Noraznawati
Published: March 2023

Marine resources such as marine invertebrates and mangrove plants favor the production of secondary metabolites that exhibit antifouling properties. These natural-derived compounds are considered environmentally friendly compared to synthetic compounds with similar activity and technological applications. The current study was conducted to determine the antifouling properties of Diadema setosum (DS) and Sonneratia lanceolata (SL) crude extracts and their incorporated paints, in addition to the identification of the metabolites involved. Both crude extracts were tested against Pseudomonas aeruginosa via a crystal violet assay, while the incorporated paints with 5% (SL5% and DS5%) and 10% (SL10% and DS10%) weight per volume (w/v) were tested in an aquarium and submerged in the seawater at Kemaman and Pulau Redang (Malaysia) for field testing. The identification of the bioactive compounds from the crude extracts was carried out using Liquid Chromatography-Mass Spectrometry (LC-MS). The results of the crystal violet assay showed that both of the crude extracts reduced the biofilm formed by Pseudomonas aeruginosa. The marine bacteria growths contained in natural seawater were inhibited the most by SL5%, followed by DS5%, DS10%, and SL10% in the aquarium testing. Based on the photographic observation, all of the paints incorporated with the crude extracts successfully reduced the settlement of fouling organisms compared to the blank paint, as lesser macroalgae were found growing on the SL5%, DS5%, and DS10%. The LC-MS results showed 3-Methyloxiranyl phosphonic acid; (2RS,3SR)-form from the SL crude extract, while the 8-Decene-1,3,5-triol, 3-Hydroxyundecanoic acid, and 1-O-(6-Deoxy-6-sulfoglucopyranosyl)glycerol; α-D-form, 3-Hexadecanoyl from the DS crude extract were involved in the antifouling properties. In conclusion, both crude extracts have the potential to be developed as antifouling agents.
Study of a Method for Drivability of Monopile in Complex Stratified Soil
Authors: Zhang Jie , Shen Kanmin , Wang Bin , Wen Guangyuan , Li Sa
Published: March 2023

At present, there is no commonly used method for predicting soil resistance to the driving (SRD) of monopiles, because all available methods are developed based on an installed offshore pile with a diameter of 2–3 m. In addition, due to the complexity of soil profiles in situ, the accuracy of methods used is often not stable under different soil conditions. Based on two typical stratified soil conditions of offshore wind farms in the East China Sea, which are clay-interlayered sand and sand-interlayered clay where, according to the pile driving records of the monopiles in sites, the SRD is obtained by back analysis using the method of the wave equation. At the same time, SRD is also calculated using Steven and Alm methods and compared with that of the back analysis. The results show that the SRDs from the Steven and Alm methods are basically consistent with that of the back analysis, but the predicted SRD of the clay layer is higher than that of back analysis, while the predicted SRD of the sand layer is lower. Based on the characteristics of SRD in different soil layers, a modified method for calculating unit friction in clay and the unit end resistance in sand is proposed for stratified soil, and the error between SRD of the proposed method and of the back analysis was approximately 20%. It could be helpful to improve the accuracy of the monopile drivability analysis in stratified soil.
A Refined Collaborative Scheduling Method for Multi-Equipment at U-Shaped Automated Container Terminals Based on Rail Crane Process Optimization
Authors: Yang Yongsheng , Sun Shu , Zhong Meisu , Feng Junkai , Wen Furong , Song Haitao
Published: March 2023

A U-shaped automated container terminal (ACT) has been proposed for the first time globally and has been adopted to construct the Beibu Gulf Port ACT. In this ACT layout, the double cantilevered rail crane (DCRC) simultaneously provides loading and unloading services for the external container trucks (ECTs) and the automatic guided vehicles (AGVs) entering the yard. The DCRC has a complex scheduling coupling relationship with the AGV and the ECT, and its mathematical model is extremely complex. There is an urgent need to study a practical collaborative scheduling optimization model and algorithm for the DCRC, the AGV, and the ECT. In this paper, we optimize the process flow of DCRCs to study the refined collaborative scheduling model of DCRCs, AGVs and ECTs in U-shaped ACTs. Firstly, we analyze the operation process of the DCRC and divide the 16 loading and unloading conditions of the DCRC into four operation modes for process optimization. Secondly, different variables and parameters are set for the DCRC’s four operating modes, and a refined collaborative dispatching model for the DCRCs with AGVs and ECTs is proposed. Finally, a practical adaptive co-evolutionary genetic algorithm solves the model. Meanwhile, arithmetic examples verify the correctness and practicality of the model and algorithm. The experimental results show that the total running time of the DCRCs is the shortest in the U-shaped ACT when the number of quay cranes (QC) to DCRC and AGV ratios are 1:2 and 1:10, respectively. At the same time, the number of QCs and DCRCs has a more significant impact on the efficiency of the ACT than that of AGVs, and priority should be given to the allocation of QCs and DCRCs. The research results have essential guidance value for U-shaped ACTs under construction and enrich the theory and method of collaborative scheduling of U-shaped ACT equipment.
Crop Diversification to Control Rust in Faba Bean Caused by Uromyces viciae-fabae
Authors: Villegas-Fernández Ángel M. , Amarna Ahmed A. , Moral Juan , Rubiales Diego
Published: March 2023

Uromyces viciae-fabae is a highly specific biotrophic fungus that causes faba bean rust, one of the major diseases affecting this crop. We have assessed the feasibility of using intercropping (faba bean mixed with either pea, wheat or barley) or mixtures of susceptible and resistant cultivars to control rust both under field and controlled conditions. The results of four field intercropping experiments showed a significant reduction in rust severity on faba bean when intercropped with barley (average 22% reduction) but not with the other combinations. This reduction was also confirmed in studies under controlled conditions. The barrier effect of barley appears as the main mechanism explaining rust suppression. Additional experiments under controlled conditions showed that intercropping with barley did not influence the N content of faba bean and that different levels of N nutrition had no impact on rust severity in any case. The cultivar mixture field experiments showed that rust severity in the susceptible cultivar decreased as the proportion of the resistant cultivar in the mixture increased. The importance of the barrier effect of the resistant cultivars was determined in an experiment under controlled conditions. It can be concluded that crop diversification offers great potential to reduce rust in faba bean.
Finite Element Analysis of Channel Screw and Conventional Plate Technique in Tile B2 Pelvic Fracture
Authors: Li Dejian , Ren Hanru , Zhang Xu , Ao Rongguang , Yi Chengqing , Yu Baoqing
Published: March 2023

Objective: This study aims to analyze the biomechanical characteristics of tile B2 pelvic fractures using finite element analysis when the superior ramus of the pubis was fixed by a plate or hollow screws in standing and sitting positions, respectively. Methods: A three-dimensional digital model of the tile B2 pelvic fracture was obtained by CT scanning the patient. The main ligament structure was then reconstructed based on the anatomical characteristics to create a finite element model of the tile B2 pelvic fracture. The posterior pelvic ring was fixed by sacroiliac joint screws, while the anterior ring injury of the superior ramus of the pubis was fixed by plates and hollow compression screws, respectively. The degrees of freedom of the bilateral acetabulum or two sides of the ischial tuberosity were constrained in the two models. A vertical load of 600 N was applied to the upper surface of the sacrum to measure the displacement and stress distribution of the pelvis in the standing and sitting positions. Results: The displacement distribution of both the healthy and the affected side of the pelvis was relatively uniform in both the plate group and the hollow screw group according to the finite element simulation results. The maximum displacement value in the sitting position was greater than the standing position, and the maximum displacement value of the hollow screw fixation was greater than that of the plate fixation. In the four groups of fixation models, the maximum displacement value of the pelvis in the hollow screw sitting position group was 1616.80 × 10−3 mm, which was greater than that of the other three groups, and in this group the total displacement value of the hollow screw in the anterior ring was 556.31 × 10−3 mm. The stress distribution of the pelvis in the various models was similar in the four groups of models, in which the maximum stress of the pelvis in the hollow screw sitting position group was the largest, which was 201.33 MPa, while the maximum stress in the standing position was 149.85 MPa greater than that in the sitting position of the hollow screw fixation. Conclusion: The anterior ring of patients with Tile B2 pelvic fractures fixed with hollow screws or plates in both standing and sitting positions can achieve satisfactory biomechanical results with significant safety margins for plates and screws.
Prognostic Value of Serum Transferrin Level before Radiotherapy on Radio-Sensitivity and Survival in Patients with Nasopharyngeal Carcinoma
Authors: Zhan Yuping , Su Li , Lin Qiaojing , Pan Xiaoxian , Li Xiaoxia , Zhou Weitong , Zhang Weijian , Hong Jinsheng
Published: March 2023

Purpose: To investigate the prognostic value of serum transferrin (TRF) level before intensity-modulated radiation therapy (IMRT) on radio-sensitivity and overall survival (OS) in patients with nasopharyngeal carcinoma (NPC). Methods: From October 2012 to October 2016, a total of 348 patients with NPC in the First Affiliated Hospital of Fujian Medical University were retrospectively analyzed in our study. The concentration of serum TRF was detected by the method of enzyme-linked immunosorbent assay (ELISA). In the whole group, 46 patients received IMRT, and 302 patients received IMRT plus chemotherapy. The radio-sensitive tumor was defined when the local tumor lesions disappeared completely in the nasopharyngeal MRI scan and no tumor residues were found under the electronic nasopharyngoscope one month after the end of radiotherapy. Results: The serum TRF level before IMRT was (1.34–3.89) g/L, with a median of 2.16 g/L and a mean of (2.20 ± 0.42) g/L. In the whole group, 242 cases (69.5%) were radiosensitive, and 106 cases (30.5%) were insensitive. The number of radiosensitive patients in the group of HTRF (transferrin > 2.16 g/L) and LTRF (transferrin ≤ 2.16 g/L) before radiotherapy was 129 (74.6%) and 113 (64.6%), respectively. The difference in radio-sensitivity between the two groups was statistically significant (χ2 = 4.103, p = 0.043). Logistic regression analysis showed that the level of TRF before radiotherapy (OR = 1.702; 95% CI 1.044~2.775; p = 0.033) was an independent factor for radio-sensitivity. The log-rank test showed that patients in the LTRF group achieved a significantly worse OS (χ2 = 5.388, p = 0.02) than those in the HTRF group. Cox regression analysis showed that baseline TRF level (HR = 1.706; 95% CI 1.065~2.731; p = 0.026) was an independent prognostic factor for overall survival. Conclusions: The low level of TRF before IMRT is a risk factor for radio-sensitivity and a prognostic factor for poor OS in NPC patients. It may be a promising marker to predict radio-sensitivity and OS in NPC patients who accept IMRT.
Land-Use/Land-Cover Change and Ecosystem Service Provision in Qinghai Province, China: From the Perspective of Five Ecological Function Zones
Authors: Ma Xiaofan , Zhang Haifeng
Published: March 2023

Qinghai Province is an important part of the Qinghai-Tibet Plateau and has special importance in the construction of ecological civilisation in China, which is related to the ecological security of the country and long-term development. The land is the basis of terrestrial ecosystem services. Land use/cover change (LUCC) can alter the structure, distribution and processes of terrestrial ecosystems, thereby affecting ecosystem services. Ecological Function Zone (EFZ) is the special zone designated by the government to protect ecosystems more effectively. Studying the response of ecosystem services value (ESV) to LUCC within EFZ is of great significance to the construction of ecological civilization in Qinghai Province. This study uses five periods of land use data from 1980 to 2020 and selects the equivalent factor method, correction method and elasticity model to analyse the characteristics of land use change and its impact on the value of ecosystem services. The conclusions are as follows. (1) The results showed that the ESV of Qinghai Province decreased from 822.559 billion yuan in 1980 to 819.903 billion yuan in 2000, and then increased rapidly to 905.775 billion yuan in 2020, showing a total increase of 83.216 billion yuan (1 RMB equates to 0.144129 USD). The restoration of grassland and the expansion of water bodies are the main reasons for the growth of ESV. (2) The ESV of Sanjiangyuan EFZ was the highest, followed by Qaidam EFZ, Qinghai Lake EFZ and Qilian Mountains EFZ, while Hehuang EFZ was the lowest. (3) The elasticity of the ESV to LUCC generally declined in all EFZs. Every 1% change in the LUCC in the Qaidam EFZ will result in a 4.78% change in ESV, followed by the Sanjiangyuan EFZ (2.56%), Qilian Mountains EFZ (2.1%), Qinghai Lake EFZ (1.01%), and the Hehuang EFZ with the lowest elasticity index (0.53%). (4) The distribution of the high values of the ESV elasticity gradually expands, with a clear spatial distribution characteristic of high west and low east. (5) The most suitable area for urban construction in Qinghai Province is the Hehuang EFZ, and urban construction in the Qaidam EFZ should avoid encroaching on water bodies or polluting water sources. The conclusions can provide a reference for optimising the land use structure and harmonising conservation and development in Qinghai Province.
The Role of Historical Data to Investigate Slow-Moving Landslides by Long-Term Monitoring Systems in Lower Austria
Authors: Marr Philipp , Jiménez Donato Yenny Alejandra , Carraro Edoardo , Kanta Robert , Glade Thomas
Published: March 2023

Landslides are one of the most significant natural hazards worldwide. They can have far-reaching negative impacts on societies in different socio-economic sectors as well as on the landscape. Among the different types and processes that can also affect infrastructure and land use planning, slow-moving landslides are often underestimated. Therefore, studying areas affected by slow movements provide an opportunity to better understand the spatial and temporal patterns of these processes, their forcings, mechanisms, and potential risks. This study aims to investigate the importance of historical data for improving landslide hazard assessment in Lower Austria (Austria), which is particularly prone to landslides. This paper focuses on how historical information formed the basis for the establishment of three long-term landslide monitoring observatories in this region. The analysis conducted highlights the importance of using historical data to better assess the frequency and magnitude relationships and phases of landslide activity. In particular, they can extend the temporal window and provide relevant information on past events and accelerations to improve knowledge of landslide dynamics and the resulting socio-economic impacts. In order to better assess the landslide hazard associated, it is necessary to integrate historical data and monitoring datasets obtained by surface and subsurface methods. Both components allow for the characterization of the spatio-temporal evolution of slow movements and the analysis of the hazard over time. Based on a variety of historical sources, it was possible to install the instruments constituting the long-term landslide monitoring observatories in a meaningful manner. The results demonstrate the influential role of human impact on the stability conditions, which may also contribute to landslide occurrence. In this regard, the attempt to combine historical data and long-term, continuous monitoring systems in the presented landslide observatories can improve landslide risk reduction measures in the region. The integration of different techniques and tools, along with ongoing research and collaboration with local authorities, will further improve our understanding of these slow-moving processes and the development of effective management strategies.
The Extension of Vegetable Production to High Altitudes Increases the Environmental Cost and Decreases Economic Benefits in Subtropical Regions
Authors: Liang Tao , Tao Weilin , Wang Yan , Zhou Na , Hu Wei , Zhang Tao , Liao Dunxiu , Chen Xinping , Wang Xiaozhong
Published: March 2023

Global warming has driven the expansion of cultivated land to high-altitude areas. Intensive vegetable production, which is generally considered to be a high economic value and high environmental risk system, has expanded greatly in high-altitude mountainous areas of China. However, the environmental cost of vegetable production in these areas is poorly understood. In this study, pepper production at low (traditional pepper production area) and high (newly expanded area) altitudes were investigated in Shizhu, a typical pepper crop area. The output and environmental cost at the two altitudes were identified. the influence of resource inputs, climate, and soil properties on pepper production was evaluated. There were obvious differences in output and environmental cost between the two altitudes. High-altitude pepper production achieved a 16.2% lower yield, and had a higher fertilizer input, resulting in a 22.3% lower net ecosystem economic benefit (NEEB), 23.0% higher nitrogen (N) footprint and 24.0% higher carbon (C) footprint compared to low-altitude farming. There is potential for environmental mitigation with both high- and low-altitude pepper production; Compared to average farmers, high-yield farmers groups reduced their N and C footprints by 16.9–24.8% and 18.3–25.2%, respectively, with 30.6–34.1% higher yield. A large increase in yield could also be achieved by increasing the top-dress fertilizer rate and decreasing the plant density. Importantly, high-altitude pepper production was achieved despite less advanced technology and inferior conditions (e.g., a poor road system and uneven fields). It provides a reference for the study of the environmental cost of other high-altitude regions or other crop systems at high-altitude areas.