bluuebunny/crossref_metadata_2025 huggingface dataset:
Heat Vulnerability and Heat Island Mitigation in the United States
Authors: Lim Jungmin , Skidmore Mark
Published: May 2020

Heat waves are the deadliest type of natural hazard among all weather extremes in the United States. Given the observed and anticipated increase in heat risks associated with ongoing climate change, this study examines community vulnerability to extreme heat and the degree to which heat island mitigation (HIM) actions by state/local governments reduce heat-induced fatalities. The analysis uses all heat events that occurred over the 1996–2011 period for all United States counties to model heat vulnerability. Results show that: (1) Higher income reduces extreme heat vulnerability, while poverty intensifies it; (2) living in mobile homes or rental homes heightens susceptibility to extreme heat; (3) increased heat vulnerability due to the growth of the elderly population is predicted to result in a two-fold increase in heat-related fatalities by 2030; and (4) community heat island mitigation measures reduce heat intensities and thus heat-related fatalities. Findings also show that an additional locally implemented measure reduces the annual death rate by 15%. A falsification test rules out the possibility of spurious inference on the life-saving role of heat island mitigation measures. Overall, these findings inform efforts to protect the most vulnerable population subgroups and guide future policies to counteract the growing risk of deadly heat waves.
Activation of 3-Mercaptopyruvate Sulfurtransferase by Glutaredoxin Reducing System
Authors: Nagahara Noriyuki
Published: May 2020

Glutaredoxin (EC 1.15–1.21) is known as an oxidoreductase that protects cysteine residues within proteins against oxidative stress. Glutaredoxin catalyzes an electron transfer reaction that donates an electron to substrate proteins in the reducing system composed of glutaredoxin, glutathione, glutathione reductase, and nicotinamide-adenine dinucleotide phosphate (reduced form). 3-mercaptopyruvate sulfurtransferase (EC 2.8.1.2) is a cysteine enzyme that catalyzes transsulfuration, and glutaredoxin activates 3-mercaptopyruvate sulfurtransferase in the reducing system. Interestingly, even when glutathione or glutathione reductase was absent, 3-mercaptopyruvate sulfurtransferase activity increased, probably because reduced glutaredoxin was partly present and able to activate 3-mercaptopyruvate sulfurtransferase until depletion. A study using mutant Escherichia coli glutaredoxin1 (Cys14 is the binding site of glutathione and was replaced with a Ser residue) confirmed these results. Some inconsistency was noted, and glutaredoxin with higher redox potential than either 3-mercaptopyruvate sulfurtransferase or glutathione reduced 3-mercaptopyruvate sulfurtransferase. However, electron-transfer enzymatically proceeded from glutaredoxin to 3-mercaptopyruvate sulfurtransferase.
Endocrine-Disrupting Chemicals and Insulin Resistance in Children
Authors: Rotondo Eleonora , Chiarelli Francesco
Published: May 2020

The purpose of this article is to review the evidence linking background exposure to endocrine-disrupting chemicals (EDCs) with insulin resistance in children. Although evidence in children is scarce since very few prospective studies exist even in adults, evidence that EDCs might be involved in the development of insulin resistance and related diseases such as obesity and diabetes is accumulating. We reviewed the literature on both cross-sectional and prospective studies in humans and experimental studies. Epidemiological studies show a statistical link between exposure to pesticides, polychlorinated bisphenyls, bisphenol A, phthalates, aromatic polycyclic hydrocarbides, or dioxins and insulin resistance.
The Influence of Sleep Quality, Vigilance, and Sleepiness on Driving-Related Cognitive Abilities: A Comparison between Young and Older Adults
Authors: Bartolacci Chiara , Scarpelli Serena , D’Atri Aurora , Gorgoni Maurizio , Annarumma Ludovica , Cloos Chiara , Giannini Anna Maria , De Gennaro Luigi
Published: May 2020

Background: Driving performance is strongly vulnerable to drowsiness and vigilance fluctuations. Excessive sleepiness may alter concentration, alertness, and reaction times. As people age, sleep undergoes some changes, becoming fragmented and less deep. However, the effects of these modifications on daily life have not been sufficiently investigated. Recently, the assessment of sleepiness became mandatory in Europe for people at risk who need the driving license release. Moreover, considering the expectation that people around the world are rapidly aging, it is necessary to investigate the relationships between senescence sleep changes, vigilance levels, and driving-related cognitive skills. Method: 80 healthy subjects (40 young adults and 40 elders) participated in the study. Sleep quality, sleepiness, and vigilance levels were assessed through the Pittsburgh Sleep Quality Index, the Karolinska Sleepiness Scale, the Epworth Sleepiness Scale, and the Psychomotor Vigilance Task (PVT). Driving-related cognitive abilities were assessed through Vienna Test System TRAFFIC, investigating selective attention, tachistoscopic perception, and risk assumption. Results: 2 × 2 between-subject ANOVAs showed less habitual sleep efficiency and worse performances in PVT in the older group. Unexpectedly, younger subjects show higher self-rated sleepiness. Moreover, older adults have lower performance in attention and perception tests, but they appear to be more cautious in situations involving traffic. Finally, the multiple regressions show age to be the only robust predictor of cognitive driving-related abilities. Conclusions: This is the first study that investigates the relationships among sleepiness/vigilance and specific driving-related cognitive skills on a sufficiently large sample. Nevertheless, the study should be considered preliminary and does not allow us to understand how specific changes in sleep architecture impact performances in the elders’ everyday life and, specifically, on driving skills.
Neural Correlates of Modality-Sensitive Deviance Detection in the Audiovisual Oddball Paradigm
Authors: Randazzo Melissa , Priefer Ryan , Smith Paul J. , Nagler Amanda , Avery Trey , Froud Karen
Published: May 2020

The McGurk effect, an incongruent pairing of visual /ga/–acoustic /ba/, creates a fusion illusion /da/ and is the cornerstone of research in audiovisual speech perception. Combination illusions occur given reversal of the input modalities—auditory /ga/-visual /ba/, and percept /bga/. A robust literature shows that fusion illusions in an oddball paradigm evoke a mismatch negativity (MMN) in the auditory cortex, in absence of changes to acoustic stimuli. We compared fusion and combination illusions in a passive oddball paradigm to further examine the influence of visual and auditory aspects of incongruent speech stimuli on the audiovisual MMN. Participants viewed videos under two audiovisual illusion conditions: fusion with visual aspect of the stimulus changing, and combination with auditory aspect of the stimulus changing, as well as two unimodal auditory- and visual-only conditions. Fusion and combination deviants exerted similar influence in generating congruency predictions with significant differences between standards and deviants in the N100 time window. Presence of the MMN in early and late time windows differentiated fusion from combination deviants. When the visual signal changes, a new percept is created, but when the visual is held constant and the auditory changes, the response is suppressed, evoking a later MMN. In alignment with models of predictive processing in audiovisual speech perception, we interpreted our results to indicate that visual information can both predict and suppress auditory speech perception.
Cortical Thickness and Natural Scene Recognition in the Child’s Brain
Authors: Orliac François , Borst Grégoire , Simon Grégory , Mevel Katell , Vidal Julie , Dollfus Sonia , Houdé Olivier , Peyrin Carole , Poirel Nicolas
Published: May 2020

Visual scenes are processed in terms of spatial frequencies. Low spatial frequencies (LSF) carry coarse information, whereas high spatial frequencies (HSF) subsequently carry information about fine details. The present magnetic resonance imaging study investigated how cortical thickness covaried with LSF/HSF processing abilities in ten-year-old children and adults. Participants indicated whether natural scenes that were filtered in either LSF or HSF represented outdoor or indoor scenes, while reaction times (RTs) and accuracy measures were recorded. In adults, faster RTs for LSF and HSF images were consistently associated with a thicker cortex (parahippocampal cortex, middle frontal gyrus, and precentral and insula regions for LSF; parahippocampal cortex and fronto-marginal and supramarginal gyri for HSF). On the other hand, in children, faster RTs for HSF were associated with a thicker cortex (posterior cingulate, supramarginal and calcarine cortical regions), whereas faster RTs for LSF were associated with a thinner cortex (subcallosal and insula regions). Increased cortical thickness in adults and children could correspond to an expansion mechanism linked to visual scene processing efficiency. In contrast, lower cortical thickness associated with LSF efficiency in children could correspond to a pruning mechanism reflecting an ongoing maturational process, in agreement with the view that LSF efficiency continues to be refined during childhood. This differing pattern between children and adults appeared to be particularly significant in anterior regions of the brain, in line with the proposed existence of a postero-anterior gradient of brain development. Taken together, our results highlight the dynamic brain processes that allow children and adults to perceive a visual natural scene in a coherent way.
The Value of Dignity in Prison: A Qualitative Study with Life Convicts
Authors: Testoni Ines , Marrella Francesca , Biancalani Gianmarco , Cottone Paolo , Alemanno Francesca , Mamo David , Grassi Luigi
Published: May 2020

Background: This research is based on the perspective of dignity according to Chochinov; thus, the life imprisonment of detainees is assimilated to a severe disease. Methods: Ten male prisoners were interviewed trough Chochinov’s Dignity Therapy, and the results were analysed using thematic analysis. Results: Two areas of thematic prevalence emerged, namely, value of freedom, self-consciousness and education and their failure in jail, and life sentence as annihilation of life meaning and of the values of generativity and family. Conclusions: Life imprisonment has been described in its negativity by several respondents as a punishment worse than the death penalty. It has been compared to death itself, to a terminal illness, to torture and to a pain that grows over the years, with the awareness that despite the passing of time, you will not have the opportunity to return to your loved one and to a free life. In fact, prisoners live out their condition within a space in which any value that gives meaning to life risks being destroyed.
A Review on the Pathways of the Improved Structural Characteristics and Photocatalytic Performance of Titanium Dioxide (TiO2) Thin Films Fabricated by the Magnetron-Sputtering Technique
Authors: Wang Yu-Hsiang , Rahman Kazi Hasibur , Wu Chih-Chao , Chen Kuan-Chung
Published: May 2020

Titanium dioxide (TiO2) thin films are used for a broad range of applications such as wastewater treatment, photocatalytic degradation activity, water splitting, antibacterial and also in biomedical applications. There is a wide range of synthesis techniques for the deposition of TiO2 thin films, such as chemical vapor deposition (CVD) and physical vapor deposition (PVD), both of which are well known deposition methods. Layer by layer deposition with good homogeneity, even thickness and good adhesive nature is possible by using the PVD technique, with the products being used for photocatalytic applications. This review studies the effects of magnetron sputtering conditions on TiO2 films. This innovative technique can enhance the photocatalytic activity by increasing the thickness of the film higher than any other methods. The main purpose of this article is to review the effects of DC and RF magnetron sputtering conditions on the preparation of TiO2 thin films for photocatalysis. The characteristics of TiO2 films (i.e., structure, composition, and crystallinity) are affected significantly by the substrate type, the sputtering power, the distance between substrate and target, working pressure, argon/oxygen ratio, deposition time, substrate temperature, dopant types, and finally the annealing treatment. The photocatalytic activity and optical properties, including the degree of crystallinity, band gap (Eg), refractive index (n), transmittance (T), and extinction coefficient (k), of TiO2 films are dependent on the above- mentioned film characteristics. Optimal TiO2 films should have a small particle size, a strong degree of crystallinity, a low band gap, a low contact angle, a high refractive index, transmittance, and extinction coefficient. Finally, metallic and nonmetallic dopants can be added to enhance the photocatalytic activity of TiO2 films by narrowing the band gap.
Development of Cerium-Doped Hydroxyapatite Coatings with Antimicrobial Properties for Biomedical Applications
Authors: Predoi Daniela , Iconaru Simona Liliana , Predoi Mihai Valentin , Groza Andreea , Gaiaschi Sofia , Rokosz Krzysztof , Raaen Steinar , Negrila Catalin Constantin , Prodan Alina-Mihaela , Costescu Adrian , Badea Monica Luminita , Chapon Patrick
Published: May 2020

Antibacterial cerium-doped hydroxyapatite (Ce-HAp) layers have been researched sparingly in recent years. The Ce-HAp powder, Ca10−xCex(PO4)6(OH)2 with xCe = 0.05, was obtained by an adapted chemical co-precipitation method at room temperature. The target was prepared using the Ce-HAp (xCe = 0.05) powder sintered in air at 600 °C. The coatings on the Ti substrate were generated in plasma using a radio frequency (RF) magnetron sputtering discharge in an Ar gas flow in a single run. To collect the most complete information regarding the antimicrobial activity of cerium-doped hydroxyapatite with xCe = 0.05, (5Ce-HAp), antimicrobial studies were carried out both on the final suspensions and on the coated surfaces. The target was tested using ultrasound measurement, transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), glow-discharge optical emission spectroscopy (GDOES), and X-ray photoelectron spectroscopy (XPS). The present study exhibited for the first time results of the homogeneous coatings of hydroxyapatite doped with cerium using a radio frequency magnetron sputtering technique. In addition, this study highlighted for the first time the stability of the cerium-doped hydroxyapatite gels used in the creation of the coating. Ultrasound measurements on the concentrated suspension of 5Ce-HAp showed a good stability compared to double distilled, water which was chosen as the reference fluid. Particles with spherical shape were observed by both TEM and SEM analysis. The broadening of the IR bands in the IR spectrum of the 5Ce-HAp film in comparison with the IR spectrum of the precursor target indicate the formation of interlinked bonds into the layer bulk. XPS analysis revealed that the mixture of Ce3+ and Ce4+ ions in the hydroxyapatite (HAp) structure of the coatings could be due to the deposition process. The surface of 5Ce-HAp coatings was homogenous with particles having a spherical shape. A uniform distribution of all the constituent elements on the surface the 5Ce-HAp layer was revealed. The antimicrobial assays proved that both 5Ce-HAp suspensions and 5Ce-HAp coatings effectively inhibited the development of colony forming units (CFU) for all the tested microbial strains. Moreover, the antimicrobial assays emphasized that the 5Ce-HAp suspensions had a biocide effect against Escherichia coli (E. coli) and Candida albicans (C. albicans) microbial strains after 72 h of incubation.
First Record of the Nudibranch Tenellia adspersa (Nordmann, 1845) in Portugal, Associated with the Invasive Hydrozoan Cordylophora caspia (Pallas, 1771)
Authors: Encarnação João , Seyer Thomas , Teodósio Maria Alexandra , Leitão Francisco
Published: May 2020

The estuarine nudibranch Tenellia adspersa (Nordmann, 1845) was recorded for the first time in Portugal, while sampling for fouling fauna of artificial structures along the salinity gradient of the Guadiana estuary (SW Iberian Peninsula). Two specimens were found in association with the invasive hydrozoan Cordylophora caspia (Pallas, 1771) and kept in the laboratory for taxonomy purposes. After two days, batches of eggs were seen in C. caspia branches, while the nudibranchs were also actively feeding on the hydrozoan polyps. The fast generation times of T. adspersa, along with its food preference for C. caspia, might suggest a positive role of the nudibranch on controlling this invasive hydrozoan in the Guadiana estuary. Introduction routes and facilitation interactions are discussed.
Epithelial-Mesenchymal Transition Proteins in Neuroendocrine Neoplasms: Differential Immunohistochemical Expression in Different Sites and Correlation with Clinico-Pathological Features
Authors: Guadagno Elia , Campione Severo , Pignatiello Sara , Borrelli Giorgio , De Dominicis Gianfranco , De Rosa Nicolina , Del Basso De Caro Marialaura
Published: May 2020

The first step leading to metastasis, or for the acquisition of local invasiveness, involves changes in the phenotype of neoplastic cells in the primary tumor. The epithelial–mesenchymal transition (EMT) is a process that determines the acquisition of a form and a transcriptional program that are characteristic of mesenchymal cells, in epithelial cells. The factors involved in this process are E-cadherin and N-cadherin adhesion proteins and some transcription factors such as Slug and Twist. EMT is a site-specific mechanism that is also active in embryogenesis—embryonic cells are affected if invested in certain points, probably due to the signals emanating from the cells or groups of surrounding cells. It is known that neuroendocrine neoplasms have a biological behavior that differs in grading, staging, and site. The aim of our study was to investigate the immunohistochemical expression of EMT factors (Twist, Slug, and E-cadherin) in the neuroendocrine neoplasms of the gastrointestinal tract, the pancreas, and lungs, in 65 cases retrieved from the archives of the Department of Pathology, of three hospitals. The immunoscores were compared in each site and correlated with the clinico-pathological parameters. Statistical evaluation revealed an association between the higher Twist immunoscore and higher grading (p value < 0.0001) and staging (p value = 0.0055). Slug was detected only in pancreatic cases where its reduced expression was associated with a higher grading (p value = 0.0033). This data could be of diagnostic utility in the case of metastases from neuroendocrine neoplasm, to define the site of the primitive tumor when the traditional immunohistochemical panel is not sufficient. In summary, our results indicated, first that the EMT is also an active process in neuroendocrine neoplasms. To the best of our knowledge, this was the first study that evaluated the expression of EMT factors in neuroendocrine neoplasms of different districts.
New Constructions of Identity-Based Dual Receiver Encryption from Lattices
Authors: Liu Yuan , Wang Licheng , Shen Xiaoying , Li Lixiang
Published: May 2020

Dual receiver encryption (DRE), being originally conceived at CCS 2004 as a proof technique, enables a ciphertext to be decrypted to the same plaintext by two different but dual receivers and becomes popular recently due to itself useful application potentials such secure outsourcing, trusted third party supervising, client puzzling, etc. Identity-based DRE (IB-DRE) further combines the bilateral advantages/facilities of DRE and identity-based encryption (IBE). Most previous constructions of IB-DRE are based on bilinear pairings, and thus suffers from known quantum algorithmic attacks. It is interesting to build IB-DRE schemes based on the well-known post quantum platforms, such as lattices. At ACISP 2018, Zhang et al. gave the first lattice-based construction of IB-DRE, and the main part of the public parameter in this scheme consists of 2 n + 2 matrices where n is the bit-length of arbitrary identity. In this paper, by introducing an injective map and a homomorphic computation technique due to Yamada at EUROCRYPT 2016, we propose another lattice-based construction of IB-DRE in an even efficient manner: The main part of the public parameters consists only of 2 p n 1 p + 2 matrices of the same dimensions, where p ( ≥ 2 ) is a flexible constant. The larger the p and n, the more observable of our proposal. Typically, when p = 2 and n = 284 according to the suggestion given by Peikert et al., the size of public parameters in our proposal is reduced to merely 12% of Zhang et al.’s method. In addition, to lighten the pressure of key generation center, we extend our lattice-based IB-DRE scheme to hierarchical scenario. Finally, both the IB-DRE scheme and the HIB-DRE scheme are proved to be indistinguishable against adaptively chosen identity and plaintext attacks (IND-ID-CPA).
Operation of Battery Storage as a Temporary Equipment During Grid Reinforcement Caused by Electric Vehicles
Authors: Held Lukas , Baumann Sebastian , Suriyah Michael R. , Leibfried Thomas , Ratajczak Levin , Lossau Selma , Konermann Martin
Published: May 2020

Electric vehicle charging stresses distribution grids significantly with high penetrations of electric vehicles. This will lead to grid reinforcement works in several distribution grids. Battery storage is a possible solution to bypass times of grid reinforcement due to electric vehicle charging. In this paper, different operation strategies for such a battery storage are tested at first in simulations. The main difference between the strategies is the necessary input data. Following the simulations, selected strategies are tested in reality in the project ”Netzlabor E-Mobility-Allee”. It is proved that battery storage is a functioning possibility to bypass times of grid reinforcement.
Meta-Modelling to Quantify Yields of White Spruce and Hybrid Spruce Provenances in the Canadian Boreal Forest
Authors: Ahmed Suborna , LeMay Valerie , Yanchuk Alvin , Robinson Andrew , Marshall Peter , Bull Gary
Published: May 2020

Tree improvement programs can improve forest management by increasing timber yields in some areas, thereby facilitating conservation of other forest lands. In this study, we used a meta-analytic approach to quantify yields of alternative white (Picea glauca (Moench) Voss) and hybrid spruce (Picea engelmannii Parry ex Engelmann x Picea glauca (Moench) Voss) stocks across planting sites in the boreal and hemiboreal forests of Canada. We extracted meta-data from published tree improvement program results for five Canadian provinces covering 38 planting sites and 330 white and hybrid spruce provenances. Using these meta-data and a random-coefficients nonlinear mixed-effects modelling approach, we modelled average height over time trajectories for varying planting site characteristics, as well as climate transfer distances between planting sites and provenances. Climatic transfer distances had strong effects on the height trajectory parameters. In particular, the asymptote parameter had a nonlinear increasing trend with planting site versus provenance mean annual temperature differences. We incorporated the height trajectory meta-analysis model into an existing growth and yield model to predict volume yields. Overall, this research provides a mechanism to quantify yields of alternative provenances at a particular planting site, as a component of decision support models for evaluating evaluate forest management investment into improved planting stocks alternatives under current and possible future climates.
Sand Ridges on Rocky Coastal Platforms as Markers of Tsunami Impact: A Multi-Disciplinary Analysis along the Ionian Coast of Southern Apulia (Italy)
Authors: Sansò Paolo , Calcagnile Lucio , Fago Paola , Mazzotta Sara , Negri Sergio , Quarta Gianluca , Romagnoli Claudia , Vitale Andrea , Mastronuzzi Giuseppe
Published: May 2020

Along the Ionian coast of Southern Apulia, a sand ridge has been detected at the inner border of a wide, low-elevated rocky platform. A multi-disciplinary analysis was carried out to define the main geomorphological and sedimentological features of this dune-like coastal deposit, to clarify its nature as well as to obtain chronological constraints for its development. The geomorphological survey reveals that the sand ridge is about 40–60 m wide, reaching a maximum elevation of 3.9 m above m.s.l., whereas its thickness can be estimated between 1.0 and 2.8 m. The sand ridge is in some places associated with large-size boulders. Grain size analysis shows that it is made up of poorly sorted coarse-medium sands with a gravelly fraction, without significant sedimentary structures, as confirmed by Ground Penetrating Radar survey. The micro and macro-faunal assemblage sampled in the sand ridge can be related to shallow-water environments with Posidonia oceanica meadows occurring offshore. The development of the studied sand ridge can be ascribed to a tsunami event able to mix up very coarse bioclastic sands placed at submerged platforms, storm beach deposits covering the low-elevated coastal platform in patches, and possibly older tsunami deposits. Accelerator Mass Spectometry radiocarbon age determinations on mollusc shells sampled from the sand ridge span from 929–1168 AD to 1707–1950 AD and cluster around the 18th–19th centuries, suggesting a possible association with a recent tsunami event. Data reported in the Euro-Mediterranean Tsunami Catalogue would indicate as the most likely event that one of the 25th April 1836, produced by a strong earthquake with its epicenter near Rossano village, on the Ionian coast of the Calabria region.
Thunderstorm Asthma Epidemic—A Systematic Review of the General Practice Perspective
Authors: Farouque Ambereen , Walker Rae , Erbas Bircan
Published: May 2020

Thunderstorm asthma (TA) epidemics have been recognized globally as a rare phenomenon, producing a rapid surge of acute asthma presentations leading to an increased demand on emergency medical services and healthcare resources. General practitioners (GPs) are well placed in the community to contribute to healthcare during TA epidemics and similar disaster events. The aim of this review was to synthesize current evidence of the experiences of GPs during TA epidemics and similar surge events. A comprehensive systematic search of eleven electronic databases, including ancestry searching for peer-reviewed studies and grey literature published in English was conducted. Quantitative and qualitative study designs were included, and a quality assessment conducted. Of the 125 records identified, 16 were included for synthesis. During TA epidemics and surge events, GPs experience an increased demand for services, yet it is not known if general practice clinics experience resource limitations from this patient surge. While GPs express a willingness to help, few structures are in place to liaise, support and provide information to GPs during surge events. Following most surge/disaster events, no GP data is collected so it is not known how to improve coordination and communication between general practice services and emergency services. GPs have well-functioning adaptive management systems, and resources of space, supplies and staff thus the ability to increase surge capacity of their clinics.
Decision-Making in Youth Team-Sports Players: A Systematic Review
Authors: Silva Ana Filipa , Conte Daniele , Clemente Filipe Manuel
Published: May 2020

The aim of this systematic review conducted in the topic of youth team-sports players was three-fold: (i) Analyze the variations of decision-making processes between low- and high-level youth players; (ii) analyze the variations of decision-making processes between different age groups; and (iii) analyze the effects of decision-making training-based programs on youth players. Following the preferred reporting items for systematic reviews and meta-analyses (PRISMA) guidelines, this systematic review searched for studies on PubMed, ScienceDirect, Academic Search Complete, SPORTDiscus, and Taylor & Francis Online. The search returned 6215 papers. After screening the records against set criteria, 26 articles were fully reviewed. From the included studies, 9 were focused on comparing the decision-making process between low- and high-level players, 6 compared the decisions made by players from different age categories, and 11 analyzed the effects of decision-making-based training programs on youth players. Comparisons between high- and low-level players suggested that high-level and most talented players present a greater accuracy in the cognitive and executive answers to the game as well as being more adjustable to more complex situations. Considering the comparisons between age groups, a tendency of older players to execute more accurate decisions in the game and to have better tactical knowledge and behavior was observed. Finally, the effects of decision-making training programs suggest a beneficial effect employing practical scenarios (mainly based on small-sided and conditioned games), primarily improving passing decisions and execution. However, the benefits of interventions using videos are not clear.
Nurses’ Perceptions of Professional Practice Environment and Its Relation to Missed Nursing Care and Nurse Satisfaction
Authors: Zeleníková Renáta , Jarošová Darja , Plevová Ilona , Janíková Eva
Published: May 2020

The professional practice environment is a factor that can have a significant impact on missed nursing care. The study aimed to find a relationship between nurses’ perceptions of their professional practice environment and missed nursing care and job satisfaction. An additional aim was to find differences in nurses’ perceived rating of the professional practice environment according to hospital location and job position. A descriptive correlational study was performed. The sample included 513 general and practical nurses providing direct care in nine Czech hospitals. The Revised Professional Practice Environment scale and the Missed Nursing Care (MISSCARE) survey were used to collect data. The professional practice environment was most correlated with satisfaction with the current position (0.4879). The overall score of missed care correlated most strongly with the subscale “staff relationships” (−0.2774). Statistically significant differences in the rating of two subscales, “control over practice” and “cultural sensitivity”, were found between nurses from hospitals in district capitals and those from hospitals in smaller cities. Statistically significant differences in the rating of the “leadership and autonomy in clinical practice” and “teamwork” subscales were found between general nurses and practical nurses. The professional practice environment is related to nurse satisfaction and missed nursing care.
Social and Structural Determinants of Household Support for ART Adherence in Low- and Middle-Income Countries: A Systematic Review
Authors: Campbell Linda , Masquillier Caroline , Thunnissen Estrelle , Ariyo Esther , Tabana Hanani , Sematlane Neo , Delport Anton , Dube Lorraine Tanyaradzwa , Knight Lucia , Kasztan Flechner Tair , Wouters Edwin
Published: May 2020

Adherence to HIV antiretroviral therapy (ART) is a crucial factor in health outcomes for people living with HIV (PLWH). Interventions to support ART adherence are increasingly focused on the household as a source of social support. This review aims to examine the social and structural determinants of support for ART adherence within households and families in low- and middle-income countries (LMICs). The review methodology followed the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guidelines. Seven databases were searched for peer-reviewed literature. The terms searched thematically covered (1) ART adherence, (2) household and family and (3) support and care. Thirty-three studies conducted in 15 LMICs were selected and a mixed methods synthesis was undertaken. Social and structural determinants affected the type, quality and amount of support for PLWH of all ages, which affected PLWH’s ART adherence. Gender norms affected the type of support that household members give to PLWH. Education moderated household support for ART adherence through literacy and language skills. Cultural context, religious beliefs, and social norms reinforced or undermined household support for ART adherence. Stigma affected disclosure, generated secrecy around giving medication and impeded access to support from the community. Supporting PLWH exacerbated economic hardship for household members. Health system dysfunction negatively impacted trust and communication between household members and health professionals. Intersecting social and structural determinants particularly affected the care given by household members who were older, female, with little education and low socioeconomic status. Household members were able to overcome some of these barriers when they received support themselves. Household interventions to support PLWH’s ART adherence should take structural factors into account to have maximum impact.
Accelerometer-Measured Diurnal Patterns of Sedentary Behavior among Japanese Workers: A Descriptive Epidemiological Study
Authors: Kurosawa Sayaka , Shibata Ai , Ishii Kaori , Javad Koohsari Mohammad , Oka Koichiro
Published: May 2020

Increased sedentary behavior (SB) can adversely affect health. Understanding time-dependent patterns of SB and its correlates can inform targeted approaches for prevention. This study examined diurnal patterns of SB and its sociodemographic associations among Japanese workers. The proportion of sedentary time (% of wear time) and the number of breaks in SB (times/sedentary hour) of 405 workers (aged 40–64 years) were assessed using an accelerometer. SB patterns and sociodemographic associations between each time period (morning, afternoon, evening) on workdays and nonworkdays were examined in a series of multivariate regression analyses, adjusting for other sociodemographic associations. On both workdays and nonworkdays, the proportion of sedentary time was lowest in the morning and increased towards evening (b = 12.95, 95% CI: 11.28 to 14.62; b = 14.31, 95% CI: 12.73 to 15.88), with opposite trend for breaks. Being male was consistently correlated with SB. Other sociodemographic correlates differed depending on time-of-day and day-of-the-week. For instance, desk-based workstyles and urban residential area were associated with SB during workday mornings and afternoons, being single was related to mornings and evenings, workdays and nonworkdays. Initiatives to address SB should focus not only on work-related but time-of-day contexts, especially for at-risk subgroups during each period.
Promoting or Inhibiting? The Impact of Environmental Regulation on Corporate Financial Performance—An Empirical Analysis Based on China
Authors: Deng Xiang , Li Li
Published: May 2020

Today, environmental protection has become a global issue, and various environmental regulations have been actively adopted. However, are these measures promoting or harming enterprise values? Is this effect the same for enterprises with different ownership backgrounds? In order to address these problems, we conducted an empirical analysis of China’s A-share market to investigate the relationship between the New Environmental Protection Law (NEPL) launched in China and corporate financial performance, and further explore the impact of environmental supervision intensity (ESI) from the perspective of ownership. The empirical results show that there is a negative correlation between NEPL and the financial performance of high pollution enterprises. Further analysis demonstrates that there is an inverted U-shape relationship between ESI and corporate financial performance for both state-owned enterprises (SOEs) and non-state-owned enterprises (non-SOEs), while the financial performance of SOEs is more sensitive and tolerant to environmental regulation than that of non-SOEs. Finally, we make recommendations for the future direction of China’s ecological civilization construction and sustainable development of enterprises based on three aspects: environmental awareness, policy considerations, and sustainable development. The innovation of this paper lies in putting NEPL and corporate financial performance in the same analytical framework for the first time, which enriches the research in this field. Meanwhile, it provides a new perspective for understanding the relationship between ESI and corporate financial performance through the analysis of nonlinearity and owner heterogeneity.
Associations between Vehicle Exhaust Particles and Ozone at Home Address and Birth Weight
Authors: Olsson David , Johansson Christer , Forsberg Bertil
Published: May 2020

We have studied the associations between exhaust particles and birth weight. Adjustments were made for ozone and potential confounding factors at the individual level. The study included all singletons conceived between August 2003 and February 2013 with mothers living in Greater Stockholm. We obtained record-based register data from the Swedish Medical Birth Register. Data concerning the parents were provided by Statistics Sweden. Exposure levels for nearly 187,000 pregnancies were calculated using a validated air quality dispersion model with input from a detailed emission database. A higher socioeconomic status was associated with higher levels of exhaust particles at the home address. In this region, with rather low air pollution levels, the associations between levels of exhaust particles and birth weight were negative for all three of the studied exposure windows (i.e., first and second trimester and full pregnancy). For the entire pregnancy, the linear decrease in birth weight was 7.5 grams (95% CI−12.0; −2.9) for an increase in exposure, corresponding to the inter quartile range (IQR = 209 ng/m3). We also found that the risk of being born small for gestational age increased with the level of exhaust particles in all three exposure windows, but these associations were not statistically significant.
Neighborhood Built Environment Measures and Association with Physical Activity and Sedentary Time in 9–14-Year-Old Children in Saskatoon, Canada
Authors: Goon Shatabdi , Kontulainen Saija , Muhajarine Nazeem
Published: May 2020

This study assessed whether perceptual and researcher-rated measures of neighborhood-built environments (BEs) predict device-based multiple activity-related outcomes, specifically: moderate-to-vigorous physical activity (MVPA), light physical activity (LPA), and sedentary time (ST), in children. Eight hundred and sixteen children aged 9–14 years from Saskatoon, Canada, were surveyed on their perceptions of BE, and their PA outcomes were objectively monitored for one week at three different time frames over a one-year period, September 2014 to August 2015. The researcher-rated BE measures were collected by trained researchers using multiple BE audit tools: neighborhood active living potential (NALP) and Irvine Minnesota inventory (IMI), 2009–2010. A multilevel modeling approach was taken to understand BE influences of children’s PA outcomes. Children’s perceived availability of parks and sidewalks predicted a higher accumulation of MVPA and a lower accumulation of ST. Children’s report of the absence of neighborhood social disorder (e.g., threats from scary dogs/people) predicted a higher LPA, while reported concern about crime predicted a lower MVPA. Researcher-rated neighborhood activity friendliness predicted a lower ST, however, researcher-rated safety from crime predicted a higher ST. Perceived BE characteristic were stronger predictors of children’s PA outcomes compared to researcher-rated BE factors.
Stakeholders’ Consensus on Strategies for Self- and Other-Regulation of Video Game Play: A Mixed Methods Study
Authors: Colder Carras Michelle , Carras Matthew , Labrique Alain B.
Published: May 2020

Background: Little is known about strategies or mechanics to improve self-regulation of video game play that could be developed into novel interventions. This study used a participatory approach with the gaming community to uncover insider knowledge about techniques to promote healthy play and prevent gaming disorder. Methods: We used a pragmatic approach to conduct a convergent-design mixed-methods study with participants attending a science fiction and education convention. Six participants answered questions about gaming engagement and self- or game-based regulation of gaming which were then categorized into pre-determined (a priori) themes by the presenters during the presentation. The categorized themes and examples from participant responses were presented back to participants for review and discussion. Seven participants ranked their top choices of themes for each question. The rankings were analyzed using a nonparametric approach to show consensus around specific themes. Results: Participants suggested several novel potential targets for preventive interventions including specific types of social (e.g., play with others in a group) or self-regulation processes (e.g., set timers or alarms). Suggestions for game mechanics that could help included clear break points and short missions, but loot boxes were not mentioned. Conclusions: Our consensus development approach produced many specific suggestions that could be implemented by game developers or tested as public health interventions, such as encouraging breaks through game mechanics, alarms or other limit setting; encouraging group gaming; and discussing and supporting setting appropriate time or activity goals around gaming (e.g., three quests, one hour). As some suggestions here have not been addressed previously as potential interventions, this suggests the importance of including gamers as stakeholders in research on the prevention of gaming disorder and the promotion of healthy gaming. A large-scale, online approach using these methods with multiple stakeholder groups could make effective use of players’ in-depth knowledge and help speed discovery and translation of possible preventive interventions into practice and policy.
High Expression of Cannabinoid Receptor 2 on Cytokine-Induced Killer Cells and Multiple Myeloma Cells
Authors: Garofano Francesca , Schmidt-Wolf Ingo G. H.
Published: May 2020

Multiple myeloma (MM) is characterized by aberrant bone marrow plasma cell (PC) proliferation and is one of the most common hematological malignancies. The potential effect of cannabinoids on the immune system and hematological malignancies has been poorly characterized. Cannabidiol (CBD) may be used to treat various diseases. CBD is known to exert immunomodulatory effects through the activation of cannabinoid receptor 2 (CB2), which is expressed in high levels in the hematopoietic system. Cytokine-induced killer (CIK) cells are a heterogeneous population of polyclonal T lymphocytes obtained via ex vivo sequential incubation of peripheral blood mononuclear cells (PBMCs) with interferon-γ (IFN-γ), anti CD3 monoclonal antibody, and IL-2. They are characterized by the expression of CD3+ and CD56+, which are surface markers common to T lymphocytes and natural killer (NK) cells. CIK cells are mainly used in hematological patients who suffer relapse after allogeneic transplantation. Here, we investigated their antitumor effect in combination with pure cannabidiol in KMS-12 MM cells by lactate dehydrogenase LDH cytotoxicity assay, CCK-8 assay, and flow cytometry analysis. The surface and intracellular CB2 expressions on CIK cells and on KMS-12 and U-266 MM cell lines were also detected by flow cytometry. Our findings confirm that the CB2 receptor is highly expressed on CIK cells as well as on MM cells. CBD was able to decrease the viability of tumor cells and can have a protective role for CIK cells. It also inhibits the cytotoxic activity of CIKs against MM at high concentrations, so in view of a clinical perspective, it has to be considered that the lower concentration of 1 µM can be used in combination with CIK cells. Further studies will be required to address the mechanism of CBD modulation of CIK cells in more detail.
Human–Vehicle Integration in the Code of Practice for Automated Driving
Authors: Wolter Stefan , Caccia Dominioni Giancarlo , Hergeth Sebastian , Tango Fabio , Whitehouse Stuart , Naujoks Frederik
Published: May 2020

The advancement of SAE Level 3 automated driving systems requires best practices to guide the development process. In the past, the Code of Practice for the Design and Evaluation of ADAS served this role for SAE Level 1 and 2 systems. The challenges of Level 3 automation make it necessary to create a new Code of Practice for automated driving (CoP-AD) as part of the public-funded European project L3Pilot. It provides the developer with a comprehensive guideline on how to design and test automated driving functions, with a focus on highway driving and parking. A variety of areas such as Functional Safety, Cybersecurity, Ethics, and finally the Human–Vehicle Integration are part of it. This paper focuses on the latter, the Human Factors aspects addressed in the CoP-AD. The process of gathering the topics for this category is outlined in the body of the paper. Thorough literature reviews and workshops were part of it. A summary is given on the draft content of the CoP-AD Human–Vehicle Integration topics. This includes general Human Factors related guidelines as well as Mode Awareness, Trust, and Misuse. Driver Monitoring is highlighted as well, together with the topic of Controllability and the execution of Customer Clinics. Furthermore, the Training and Variability of Users is included. Finally, the application of the CoP-AD in the development process for Human-Vehicle Integration is illustrated.
GEdIL—Gamified Education Interoperability Language
Authors: Swacha Jakub , Paiva José Carlos , Leal José Paulo , Queirós Ricardo , Montella Raffaele , Kosta Sokol
Published: May 2020

The paper introduces Gamified Education Interoperability Language (GEdIL), designed as a means to represent the set of gamification concepts and rules applied to courses and exercises separately from their actual educational content. This way, GEdIL allows not only for an easy yet effective specification of gamification schemes for educational purposes, but also sharing them among instructors and reusing in various courses. GEdIL is published as an open format, independent from any commercial vendor, and supported with dedicated open-source software.