bluuebunny/crossref_metadata_2025 huggingface dataset:
An analysis on Quantum mechanical Stability of Regular Polygons on a Point Base Using Heisenberg Uncertainty Principle
Authors: Chapagain Anurag
Published: October 2021

Abstract: It is a well-known fact in physics that classical mechanics describes the macro-world, and quantum mechanics describes the atomic and sub-atomic world. However, principles of quantum mechanics, such as Heisenberg’s Uncertainty Principle, can create visible real-life effects. One of the most commonly known of those effects is the stability problem, whereby a one-dimensional point base object in a gravity environment cannot remain stable beyond a time frame. This paper expands the stability question from 1- dimensional rod to 2-dimensional highly symmetrical structures, such as an even-sided polygon. Using principles of classical mechanics, and Heisenberg’s uncertainty principle, a stability equation is derived. The stability problem is discussed both quantitatively as well as qualitatively. Using the graphical analysis of the result, the relation between stability time and the number of sides of polygon is determined. In an environment with gravity forces only existing, it is determined that stability increases with the number of sides of a polygon. Using the equation to find results for circles, it was found that a circle has the highest degree of stability. These results and the numerical calculation can be utilized for architectural purposes and high-precision experiments. The result is also helpful for minimizing the perception that quantum mechanical effects have no visible effects other than in the atomic, and subatomic world. Keywords: Quantum mechanics, Heisenberg Uncertainty principle, degree of stability, polygon, the highest degree of stability
Palliative Care of Auto Immune Diseases through Ayurveda with Special Emphasis on Rasaushadhi
Authors: Ghotkar Dr. Dhanashree
Published: October 2021

Abstract: With the growing economy and increasing challenges of day to day life, the chances of getting ill with serious diseases are increasing and had become very common. One of the group of diseases is the auto immune diseases. According to modern medicines an auto immune disease is supposed not to be cure completely whereas it can just be controlled for progression. Therefore, palliative care concept has got much importance in the treatment ailments. Ayurveda now experiencing its golden days due to the increasing awareness with in people for their health issues. Now people are choosing Ayurveda for their chronic conditions which were told to be impossible to cure by health professionals. There is one special branch in Ayurveda called as Rasa Shastra which is concerned about making herbo- mineral, metallo-mineral and metallic preparations. This branch is evolved during 8th century and had focused on stability of mind and body which is called as Dehavada. So it has got all the ability to treat acute as well as chronic diseases. After achieving stability of body it added Rasayana therapy to maintain the subtleness in every aspect. This article “Palliative care of Auto immune diseases through Ayurveda with special emphasis on Rasaushadhi” will discuss in detail with what is auto-immune disease palliative care and Ayurvedic Rasaushadhi. Keywords: Palliative care, auto immune disease, Ayurveda, Rasashastra, Rasauhadhi, Rasayana.
Samarkand Region Population Age Composition and Increment of Labor Resources
Authors: Aslamovich Kadirov Murod
Published: October 2021

Annotation: It is noted in the article that it is of great importance to research Samarkand Region population age composition and increment of labor resources. The direct impact of age composition to increment of labor resources is also studied in this article. Also, the issue of employment of the population is considered. Keywords: age composition, labor resources, population density, populated locality, city, village, children, adults, pensioners
The Use of Extralinguistic Means by the Sender and Addressee during the Discourse
Authors: Nafisa Muratova
Published: October 2021

Abstract: Speech conditions are the level of the listener and the speaker, their behavior in the speech process, as well as the purpose of the speech - all of these are tools other than extralinguistic linguistic units. A special place in speech is given to paralinguistic devices that accompany linguistic units in the process of interaction. The following manifestations of the use of extralinguistic means of the sender and the addressee are observed during the discourse. Keywords: paralinguistic means, extra linguistic means, sender, addressee, extralinguistic means, verbal, nonverbal means, forms of speech communication, types of speech, information exchange
Does human-dog attachment increase the resilience and resistance to COVID-19? A biopsychosocial approach and future research
Authors: Boere Vanner , Oliveira Silva Ita
Published: October 2021

This article is a biopsychosocial proposal about improvement of resilience to diseases, including the COVID-19, due to affective attachment between humans and dogs. Resilience concerns the physical and emotional human capacity to respond positively to the adverse events such as diseases. Recently, some authors have proposed independent hypotheses about role of oxytocin (OT) and crossed immunity to increase the psychological resilience and immune response against the COVID-19. This text extends the hypothesis to a biopsychosocial field, including the well-known benefits of the human-dog affective attachment on human health. And proposes that a strong and reciprocal affection between human and dog can increase the resilience and resistance to COVID-19, due the role of OT in the immune response, adding to crossed immunity. Other benefits such as emotional buffering, mental comfort and stress alleviation are adjunctive roles of dogs on human health and vice-versa.
Propiedades psicométricas del Cuestionario de Admiración y Rivalidad Narcisista (NARQ) en estudiantes universitarios de Venezuela
Authors: Chaustre Jota Daniel
Published: October 2021

La investigación tuvo como objetivo analizar las propiedades psicométricas y la adecuación del Cuestionario de Admiración y Rivalidad Narcisista (NARQ) en una muestra no probabilística de estudiantes universitarios (N = 159; 74 % mujeres) de Caracas (Venezuela), pertenecientes a una universidad privada. A través del método bola de nieve se recabó la información por medio de la administración de un cuestionario en línea. Mediante el análisis factorial exploratorio se comprobó la solución factorial propuesta, también se hallaron relaciones significativas entre admiración y rivalidad con autoestima, extraversión, apertura y afabilidad, tal como se reporta en la literatura. Se concluye que el NARQ presenta evidencias de validez y confiabilidad, y por tanto se recomienda su uso en la población venezolana.
ESTIMACIÓN DE LA TALLA DE MADUREZ SEXUAL EN REPRODUCTORES DE Neocaridina heterópoda (Camarón variedad Cherry) (Cai, 1996), EN CONDICIONES DE LABORATORIO.
Authors: Gomez Jenifer , Gomez-Nieves Vilma Y.
Published: October 2021

El camarón cherry es uno de los organismos dulceacuícolas potenciales para el desarrollo productivo por su demanda comercial en acuariofilia, debido a la escasa información que existe sobre este crustáceo, se realizó esta investigación con el propósito de conocer las tallas reproductiva de los camarones hembras y machos del género Neocaridiana sp., para lo cual se trabajó con padrotes seleccionados provenientes del laboratorio de Ingeniería en Producción Acuícola (IPA). Las hembras y machos recolectados fueron dispuestos en seis unidades experimentales, conformadas por recipientes de vidrio de 0,20 m2, con un volumen de 2000 ml y como sustrato se utilizó la macroalga o musgo Riccia fluitans. La relación de los reproductores hembra-macho fue 2:1 respectivamente. El objetivo de este trabajo fue establecer talla de madurez sexual entre machos y hembras bajo la condición de temperatura 22±1ºC del laboratorio de organismos ornamentales IPA. Los resultados obtenidos, evidencian que la madurez sexual en los machos se alcanzó en 12,1 y 14 semanas, y en las hembras en 14,2 y 16,4 semanas. Se encontró diferencias altamente significativas en talla para los reproductores; las hembras consiguieron mayor media en el tratamiento dos (2) y en los machos, se definió menor media en el tratamiento cinco (5) con 20,4 mm. Igualmente en hembras, se demostró sincronización de desoves por unidad experimental, y fecundidad estimada en 18 y 33 huevos en un desarrollo ontogénico que fluctuó entre 18 y 25 días en todos los tratamientos.
ANALISIS DE LOS RESULTADOS SABER PRO DEL PROGRAMA DE INGENIERÍA EN PRODUCCIÓN ACUÍCOLA AÑO 2016-2019
Authors: Cerón Benavides Sandra Milena , Romero-Ospina Manuel F.
Published: October 2021

La presente investigación tuvo como objetivo definir las principales variables y su incidencia sobre el puntaje de las pruebas SABER PRO dentro del programa de Ingeniería en Producción Acuícola de la Universidad de Nariño en los últimos cuatro años (2016-2019), para ello se utilizaron 384 datos correspondientes a estudiantes de noveno semestre que presentaron las pruebas de estado.

Se determinó mediante diferentes técnicas multivariadas, que todas las variables inciden sobre las dos primeras componentes, con la necesidad de fortalecer Lectura crítica, Comunicación escrita y Competencia ciudadana, las cuales tienen mayor contribución sobre las tres últimas (>50) y por lo tanto impidieron que la variabilidad retenida en las primeras sea mayor al 60%.

Por otro lado, el incumpliendo del supuesto de homocedasticidad previo al Análisis de regresión múltiple no afecto la capacidad predictiva del modelo, la cual fue del 99%, el Análisis de regresión cuantílica y sus cinco modelos no presentaron diferencias significativas entre ellos, por lo que se concluye que todas las variables son indispensables para predecir el puntaje global, cada una con su grado de contribución, calidad de asociación y peso sobre las combinaciones lineales de las dos primeras componentes.
Hypovitaminosis D in Child Population
Authors: Popovicova M. , Belovicova M. , Hudakova T.
Published: October 2021

Introduction: Hypovitaminosis D is a global problem in both, children and adults. At low vitamin D levels bone deformities, growth retardation; as well as increased susceptibility to infectious and autoimmune diseases have been observed in children. Due to its multiple systemic effect, the importance of vitamin D is irreplaceable in development of a child´s organism. The sample and aim of the research: We approached parents of 181 children who visited endocrinological and osteological outpatient clinics in Eastern Slovakia. The aim of the research was to determine the status of hypovitaminosis D in pediatric patients. We investigated the relationship between the lifestyle of a child and the occurrence of hypovitaminosis D. At the same time, we mapped parents' knowledge regarding prevention of hypovitaminosis D development being conducted at pediatric outpatient clinics. Methods: To verify the hypotheses, we used inductive statistical tools – the independent T-test and Chi - square test. Based on the calculated value and the significance level of 0.05, we made decisions about the significance of the differences. Results: By deeper analysis we found that hypovitaminosis D is more common in children with endocrine disorders. The relationship between the incidence of hypovitaminosis D and metabolic disease was not statistically significant. Parental knowledge of appropriate ways of hypovitaminosis D prevention is related to the occurrence of the disease. No significant relationship between the child's lifestyle and the occurrence of hypovitaminosis D has been confirmed. Conclusion: The occurrence of vitamin D deficiency has an adverse effect on human health. It is important to pay particular attention to this issue at the primary prevention level. We also consider it important for the parent to lead the child to an active lifestyle and to responsibility for their own health.
Reflection on Family Support Through Early Intervention Service
Authors: Lehoczka L. , Zatkova G.
Published: October 2021

A child’s disability is one of the specific events in a family. A family experiences a special, stressful situation and needs immediate, accessible assistance. The present study focuses on family support through the social service at the early intervention centre. The impact of adversity is manifested in family life in multiple contexts – health, social, psychological, pedagogical, and economic. The objective of the presented study was to identify and evaluate the progress and effectiveness of the early intervention service for a family. The study brings the case studies of families which were conducted on the basis of several methods and techniques of working with the family. Using the case studies, we monitor and evaluate its effectiveness as the assistance process.
Integrative Health Policy for Migrants in Germany
Authors: Fritsch T. , Luliak M.
Published: October 2021

It is not a new topic for Germany in receiving immigrants from various nations. However, it is thought-provoking how German integration policy is criticized to be exclusionist based on its immigration policies. 1 In Germany, efforts to integrate the current demand and needs of the migrant population into the healthcare system have proved uncoordinated and scattered as much as diversity in policy is slowly under the implementation process. Frequently, immigrants are not facing any complicated legal restrictions but it is reported that they experience extremely challenging access with barriers resulting in the worst results trying to utilize healthcare services. 2 Equal access to health care services is a crucial aspect of Germany's national health policy. Factors contributing to access barriers to healthcare are said to be: cultural differences; education; political issues; the absence of complementary voluntary health insurance. Therefore, this paper will explore the migrants’ health and barriers to healthcare access in Germany
Identification of Fall Risks by Nurses in Hospitalized Adult Patients
Authors: Slezakova Z. , Kristova J. , Miklovicova E. , Bachrata Z.
Published: October 2021

The aim of this study was to provide a nurses' comparison of fall risks in hospitalized adults according to gender, age and clinic, and to identify significant risk factors associated with the specific levels of the risk of falling. The respondent group consisted of patients hospitalized in selected hospital wards. Morse Fall Scale was used to map the data. We tested the statistical significance of differences among categories by using the chí2 test, Mann-Whitney U test and Kruskal-Wallis test. The average risk score of falling in a group of 688 patients was at a high level 47.87 ± 26.4. In the group of 430 elderly patients, we found significantly higher average values than in the group of 258 patients younger than 65 years (p = < 0.00001).Patients hospitalized in the geriatric ward had the highest average Morse Fall Scale values (55.3 ± 26.11). The results of our study confirmed the risk of falling in selected groups of patients.
Elderly Anticoagulated Patient in General Dental Practice Case Reports from everyday Life
Authors: Wulf G.
Published: October 2021

The anticoagulated elderly patient represents a major and sometimes dreaded challenge for the dentist on a daily basis, as postoperative bleeding can lead to serious problems, especially during dental surgical procedures. Knowledge of the various anticoagulants with regard to type, mode of action and influences on dental surgical procedures is indispensable for the dentist. Using case studies from the everyday life of a dental practice in a small town in Thuringia, this problem will be examined in more detail.
Possibilities of Family Solidarity and Civic Participation of Actors in the Implementation of Social Services of Self-government
Authors: Bachyncova Giertliova D.
Published: October 2021

From our point of view, the need for community planning as one of the new possibilities for improving social services in self-government is extremely important. We see the importance and contribution of the planning process for the whole local policy in the active involvement of all citizens and participants in community planning. Only if the citizens are sufficiently informed and involved in the whole process not only community planning makes sense, but also establishing cooperation and creating a network of mutual assistance in the village.
Humaniora tilsat strøm
Authors: Rasmussen Lotte Thing
Published: October 2021

Digital Humanities er et buzzword med stayingpower. Det ny center SCDH på SDU forener Digital Humanities med bibliotekets mangeårige arbejde med særsamlinger.
RUb 50 år. Fusion er det næste, naturlige skridt
Authors: Katic Stefan
Published: October 2021

RUb's bibliotekschef Joanna Ball fortæller om baggrunden for at RUb fusioneres med KB.
RUb 50 år: Ikke sikkert, at "one size fits all"
Authors: Katic Stefan
Published: October 2021

Lektor Søren Møller stopper nu efter 43 år med tilknytning til RUC og RUb. Han er kritisk over for RUb's fusionering med KB, som han frygter betyder tab af identitet og tungere beslutningsgange. Søren Møller er oprindeligt uddannet som biolog og kemiker på RUC.
Endelig kunne vi mødes igen
Authors: Katic Stefan
Published: October 2021

Billedreportage fra DFFU's første større møde live siden marts 2020.
Reação ao implante subcutâneo de Pulpdent em ratos
Authors: Oliveira Liliane Yurgel de , Pires José Antônio F. , Valle Jorge G. C. do
Published: October 2021

A type of calcyum hidroxide - PULPDENT - was implanted in the subcutaneous connetive tissue of fourteen rats one month old. The tissue eround the pellets were studied mycroscopically, after periods that ranged from one to five months. It seems, from the observations that Pulpdent is relatively weel tolerated by the organism.
Modernas ligas metálicas em odontologia
Authors: Ruhnke Luiz Antonio
Published: October 2021

No abstract available
Edgard Navarro e o escracho da história.
Authors: Roizman Geraldo Blay
Published: October 2021

Se fossemos localizar O Rei do Cagaço, 1977, dentro do universo cinematográfico de Edgard Navarro, ele faria parte, de forma mais geral, do chamado surto superoitista no Brasil, e do grande ciclo de filmes realizados em Super-8 na década de 70 que participaram de festivais da época, especificamente das chamadas Jornadas de Cinema da Bahia, e que possuíam, em geral, um forte teor provocativo ao mesmo tempo poético e político, e principalmente um sentido muito preciso de despojamento na flexibilização da linguagem possibilitada pela novidade da bitola.
Otoniel Santos Pereira, cineasta, jornalista, poeta: Invenção e Resistência
Authors: De Paula Eduardo Andre , Abramovictz Felipe
Published: October 2021

Entrevista com o cineasta, poeta e jornalista Otoniel Santos Pereira
Efeitos performativos na (des)construção de discursos de gênero e sexualidade no filme O céu sobre os ombros: uma análise a partir da direção de fotografia
Authors: Souza Vilseki Agnes Cristine , Cabral Sierra Jamil
Published: October 2021

Este artigo busca entender como discursos de gênero e sexualidade podem ser estabelecidos através da linguagem cinematográfica – especificamente a direção de fotografia – no filme brasileiro O céu sobre os ombros (Sérgio Borges, 2010), um híbrido que opera com procedimentos da ficção e do documentário. Propomos, desta forma, articular os efeitos de real construídos e tensionados pela linguagem, estabelecidos pela direção de fotografia, em diálogo com as noções de gênero e sexualidade presentes no filme. Para desenvolver e sustentar esta análise, nos apropriamos dos conceitos de dispositivo de sexualidade de Michel Foucault e de performatividade de gênero de Judith Butler, enquanto ferramentas teóricas e categorias analíticas, que nos possibilitam investigar como a fotografia cinematográfica atua construindo discursos que operam entre capturas e resistências em relação às questões de gênero e sexualidade encenadas no filme.
Aprender o quê com cada outro destes corpos? Da rave a um léxico das aparições
Authors: Moura Luís Fernando
Published: October 2021

A partir da experiência de uma rave no Recife, este texto descreve uma dinâmica figural na qual a convivência entre corpos mais e menos normais, à beira de uma aparição limítrofe, instaura intervalos e continuidades, à maneira de um jogo entre suspensão pela singularidade e proposição para a coletividade, e que teria como fim sua própria duração. Enquanto imagem, esta convivência tem em seu centro expressivo uma transição sempre em processo entre inteligibilidade das formas e fruição de confusões, ou ainda a fruição da aceleração do tempo histórico condensada na exposição de um corpo. O texto observa como o problema poderia ser endereçado na elaboração da linguagem artística crítica, particularmente ao destacar equações simbólicas entre palavra e aparição no trabalho da artista Kildery Kildery. Ao fim, tece breves perguntas a respeito de como um estudo das imagens poderia se afetar, metodologicamente, por tais intuições, tendo em vista em particular uma ética entre fluxo e vida, a viabilidade de outras genealogias e a fundação de espectatorialidades.
O beijo da mulher aranha (1981/1985) e as identificações e desidentificações pelas quais nos constituímos subjetivamente
Authors: Pontes Carlos Frederico Bustamante
Published: October 2021

O trabalho em questão teve como eixo de análise o filme O beijo da mulher aranha (Kiss of the Spider Woman, Héctor Babenco,1985) e, como ponto de partida, o espetáculo teatral homônimo, de 1981, dirigido por Ivan de Albuquerque. A proposta do artigo foi analisar o filme sob o enfoque dos estudos de gênero e sexualidades e averiguar, criticamente, se a construção de cada um dos personagens centrais do filme, Molina e Valentin, bem como o relacionamento entre eles, apontam para identificações positivas e/ou negativas dos sujeitos LGBTQAI+ com a obra. Construídos em moldes de comportamento dissidentes e hegemônicos, concluiu-se que os dois personagens citados e o filme como um todo favorecem tanto para a discussão cada vez mais atual e necessária acerca do lugar do cinema nos processos de constituição subjetiva dos/as espectadores/as quanto para avaliarmos sua atuação sociocultural enquanto veículo de reafirmação e/ou de desconstrução dos modelos de sexo e gênero dominantes.
Uma vez mais: de volta aos debates sobre cinema e ideologia
Authors: Gutierrez Maria Alzuguir
Published: October 2021

Este artigo propõe a recuperação dos debates sobre as relações entre cinema e ideologia desenvolvidos na França na passagem entre os anos 1960 e 1970, sobretudo nas revistas Cahiers du Cinéma e Cinéthique. Para tanto, elabora-se uma resenha dos principais artigos e discussões de então. Depois disso, com base em trabalho recente de um dos principais artífices daqueles debates, Jean-Louis Comolli, e em questionamentos sobre a produção audivisual contemporânea, reivindicamos a importância e a atualidade da assim chamada ''teoria do dispositivo''.
UM FILME É TODA NOSSA VIDA RESENHA DE A METAFÍSICA DA CINEFILIA, DE YVES SÃO PAULO
Authors: Freitas Rodrigues Hanna Cláudia
Published: October 2021

Yves São Paulo retoma o lugar-comum da concepção de cinefilia para desenvolver um livro por vezes difícil em seu vocabulário academicista, de linguagem sofisticada, explorando filosoficamente a cinefilia como emoção. Em A metafísica da cinefilia (2021), Yves São Paulo parte do pressuposto de que o espectador aborda o filme munido com um arsenal de experiências e ideias que o fazem colocar a obra em perspectiva. Para além disso, uma parte desta base de relação com o filme compreende a algo de ainda mais elementar, apresentado desde o princípio pelo título enigmático da obra, a metafísica. Aqui entra em ação também o subtítulo do livro, uma leitura bergsoniana do cinema, apontando o caminho do sentido de metafísica que será tratado ao longo do livro.
The effect of hormone replacement therapy on the survival of UK women: a retrospective cohort study 1984−2017
Authors: Akter Nurunnahar , Kulinskaya Elena , Steel Nicholas , Bakbergenuly Ilyas
Published: October 2021

Objective: To estimate the effect of oestrogen-only and
combined hormone replacement therapy (HRT) on the hazards of overall and
age-specific all-cause mortality in healthy women aged 46 to 65 at first
prescription.

Design: Matched cohort study.

Setting: Electronic primary care records from The Health
Improvement Network (THIN) database, UK (1984−2017).

Population: 105,199 HRT users (cases) and 224,643 non-users
(controls) matched on age and general practice.

Methods: Weibull Double-Cox regression models adjusted for age
at first treatment, birth cohort, type 2 diabetes, hypertension and
hypertension treatment, coronary heart disease,
oophorectomy/hysterectomy, body mass index, smoking, and deprivation
status.

Main outcome measures: All-cause mortality.

Results: A total of 21,751 women died over an average of 13.5
years follow-up per participant, of whom 6,329 were users and 15,422
non-users. The adjusted hazard ratio (HR) of overall all-cause mortality
in combined HRT users was 0.91 (95%CI 0.88−0.94), and in oestrogen-only
users was 0.99 (0.93−1.07), compared to non-users. Age-specific adjusted
HRs for participants aged 46-50, 51-55, 56-60, and 61-65 years at first
treatment were 0.98 (0.92−1.04), 0.87 (0.82−0.92), 0.88 (0.82−0.93), and
0.92 (0.85−0.98), for combined HRT users compared to non-users, and 1.01
(0.84−1.21), 1.03 (0.89−1.18), 0.98 (0.86−1.12), and 0.93 (0.81−1.07)
for oestrogen-only users, respectively.

Conclusions: Combined HRT was associated with a 9% lower risk
of all-cause mortality and oestrogen-only formulation was not associated
with any significant changes.

Funding: IFoA.

Keywords: Hormone replacement therapy, menopause, mortality,
primary care records, THIN.

Tweetable abstract: Oestrogen-only HRT is not associated with
all-cause mortality and combined HRT reduces the risks.
The environmental impact of inhalers for asthma; a green challenge and a golden opportunity
Authors: Wilkinson Alex , Woodcock Ashley
Published: October 2021

The propellants used in metered-dose inhalers (MDIs) are powerful
greenhouse gases, which account for approximately 13% of the NHS’s
carbon footprint related to the delivery of care. Most MDI use is in
salbutamol relievers in patients with poorly controlled disease. The UK
lags behind in this regard with greater reliance on salbutamol MDI and
correspondingly greater greenhouse gas emissions; roughly treble our
European neighbours’. There has been a broad switch towards MDIs in the
UK over the last 20 years to reduce financial costs such that two-thirds
of asthma patients in the UK are on treatment dominated by salbutamol
MDI. Strategies that replace overuse of reliever MDIs with regimes
emphasising inhaled corticosteroids have the potential to improve asthma
control alongside significant reductions in greenhouse gas emissions.
Real-world evidence shows that once-daily long-acting combination
dry-powder inhalers can improve compliance, asthma control and reduce
the carbon footprint of care. Similarly, maintenance and reliever
therapy (MART) which uses combination reliever and inhaled steroids in
one device (usually a dry-powder inhaler) can simplify therapy, improve
asthma control and reduce greenhouse gas emissions. Both treatment
strategies are popular with patients, most of whom are willing to change
treatment to reduce their carbon footprint. By focussing on patients who
are currently using high amounts of salbutamol MDI, and prioritising
inhaled steroids via dry-powder inhalers, there are golden opportunities
to make asthma care more effective, safer and greener.
Fine-scale ecological and anthropogenic variables predict the habitat use and detectability of sloth bears in the Churia habitat of east Nepal
Authors: Pokharel Manoj , Subba Asmit , Rai Dipa , Bhandari Simrik , Ghimire Yadav
Published: October 2021

Once widespread throughout the tropical forests of the Indian
Subcontinent, the sloth bears have suffered a rapid range collapse and
local extirpations in the recent decades. A significant portion of their
current distribution range is situated outside of the protected areas
(PAs). These unprotected sloth bear populations are under tremendous
human pressures, but little is known about the patterns and determinants
of their occurrence in most of these regions. The situation is more
prevalent in Nepal where virtually no systematic information is
available for sloth bears living outside of the PAs. We undertook a sign
survey-based single-season occupancy study intending to overcome this
information gap for the sloth bear populations residing in the Trijuga
forest of southeast Nepal. Sloth bear sign detection/non-detection data
and field-based covariates data were collected at the 74 randomly chosen
4-km2 grid cells using a varying number of 400m long transects in each
grid cell. From our results, the model-averaged estimate of site use
probability (ψ ± SE) was estimated to be 0.432 ± 0.039, which is a 13%
increase from the naïve estimate (0.297) not accounting for imperfect
detections of sloth bear signs. The presence of termite mounds and the
distance to the nearest water source were the most important variables
affecting the habitat use probability of sloth bears. The average
site-level detectability (p ± SE) of sloth bear signs was estimated to
be 0.195 ± 0.003 and was significantly determined by the index of human
disturbances. We recommend considering the importance of fine-scale
ecological and anthropogenic factors in predicting the sloth
bear-habitat relationships across their range in the Churia habitat of
Nepal.
Epigenetics underpins phenotypic plasticity of protandrous sex change in fish
Authors: Budd Alyssa , Robins Julie , Whybird Olivia , Jerry Dean
Published: October 2021

Phenotypic plasticity is an important driver of species resilience.
Often mediated by epigenetic changes, phenotypic plasticity enables
individual genotypes to express variable phenotypes in response to
environmental change. Barramundi (Lates calcarifer) is a protandrous
(male-first) sequential hermaphrodite that exhibit plasticity in
length-at-sex change between geographic regions. This plasticity is
likely to be mediated by changes in DNA methylation (DNAm), a
well-studied epigenetic modification. However, region-specific
relationships between length, sex and DNAm in sequential hermaphrodites
were previously unreported. To investigate these relationships, here we
compare DNAm in four conserved vertebrate sex-determining genes in male
and female barramundi of differing lengths from three regions of
northern Australia. Despite a strong association between increasing
length and male-to-female sex change, the data reveal that DNAm becomes
more sex-specific (rather than more female-specific) with length.
Significant differences in DNAm between males and females of similar
lengths suggest that female-specific DNAm arises rapidly during sex
change, rather than gradually with growth. The findings also reveal that
region-specific differences in length-at-sex change are accompanied by
differences in DNAm, and were concurrent with variability in remotely
sensed sea temperature and salinity. Together, these findings provide
the first in situ evidence for epigenetically and environmentally
mediated sex change in a protandrous hermaphrodite, and offer
significant insight into the molecular and ecological processes
governing the marked and unique plasticity of sex in fish.
Successful use of lanadelumab in an elderly patient with type II hereditary angioedema
Authors: Hellu Tasha S. , Weiss Samuel L. , Smith Derek M.
Published: October 2021

Hereditary angioedema (HAE) is a rare genetic disorder characterized by
recurring episodes of subcutaneous and/or submucosal edema without
urticaria due to an excess of bradykinin (1, 2). HAE is classified into
2 main types (1). Type I HAE is caused by deficiency of C1 esterase
inhibitor, accounting for 85% of cases (1). Type II HAE occurs in only
15% of cases and is marked by normal to elevated levels of C1 esterase
inhibitor but with a reduction in activity (1). An angioedema attack can
range in severity depending on the location and degree of edema (2).
Furthermore, patients with HAE are often diagnosed with anxiety and
depression secondary to their poor quality of life (3). Thus, long-term
prophylaxis of attacks can be crucial to reduce the physical and
psychological implications. For long-term prophylaxis, lanadelumab, a
subcutaneously delivered monoclonal antibody inhibitor of plasma
kallikrein, has been proven to decrease the frequency of HAE attacks
without significant side effects (4). However, data is limited,
specifically regarding patients with type II HAE and patients
>/= 65 years (4).
Characterization of the genetic switch from phage phi13 important for Staphylococcus aureus colonization in humans
Authors: Kristensen Camilla , Varming Anders , Leinweber Helena , Hammer Karin , Leggio Leila Lo , Ingmer Hanne , Kilstrup Mogens
Published: October 2021

Temperate phages are bacterial viruses that either reside integrated in
a bacterial genome as lysogens or enter a lytic lifecycle. Decision
between lifestyles is determined by a switch involving a phage-encoded
repressor, CI, and a promoter region from which lytic and lysogenic
genes are divergently transcribed. Here we investigate the switch of
phage phi13 from the human pathogen Staphylococcus aureus. phi13 encodes
several virulence factors and is prevalent in S. aureus strains
colonizing humans. We show that the phi13 switch harbors a cI gene, a
predicted mor (modulator of repression) gene, and three high-affinity
operator sites binding CI. To quantify the decision between lytic and
lysogenic lifestyle, we introduced reporter plasmids that carry the 1.3
kb switch region from phi13 with the lytic promoter fused to lacZ into
S. aureus and B. subtilis. Analysis of beta-galactosidase expression
indicated that decision frequency is independent of host factors. The
white “lysogenic” phenotype, which relies on expression of cI, could
be switched to a stable blue “lytic” phenotype by DNA damaging agents.
We have characterized lifestyle decisions of phage phi13, and our
approach may be applied to other temperate phages encoding virulence
factors in S. aureus.
Homotopy Continuation Enhanced Branch and Bound Algorithms for Process Synthesis Using Rigorous Unit Operation Models
Authors: Ma Yingjie , Li Jie
Published: October 2021

Process synthesis using rigorous unit operation models is highly
desirable to identify the most efficient pathway for sustainable
production of fuels and value-added chemicals. However, it often leads
to a large-scale strongly nonlinear and nonconvex mixed integer
nonlinear programming (MINLP) model. In this work, we propose two robust
homotopy continuation enhanced branch and bound (HCBB) algorithms
(denoted as HCBB-FP and HCBB-RB) where the homotopy continuation method
is employed to gradually approach the optimal solution of the NLP
subproblem at a node from the solution at its parent node. A variable
step length is adapted to effectively balance feasibility and
computational efficiency. The computational results demonstrate that the
proposed HCBB algorithms can find the same optimal solution from
different initial points, while the existing MINLP algorithms fail or
find much worse solutions. In addition, HCBB-RB is superior to HCBB-FP
due to lower computational effort required for the same locally optimal
solution.
A CFD investigation and heat transfer augmentation of double pipe heat exchanger by employing helical baffles on shell and tube side
Authors: Anantha Sobhanadri , Gnanamani Senthilkumar , Mahendran Vivekanandan , Rathinavelu Venkatesh , Rajagopal Ramkumar , Tafesse Dawit , Nadarajan Parthipan
Published: October 2021

The inclusion of baffles in a double pipe heat exchanger is becoming increasingly important as it improves the heat exchanger's performance. The CFD analysis is used in this paper to investigate the performance of double pipe heat exchangers with and without helical baffles on both shell tube sides. The 3-D CFD model was created in Solid Works, and the FloEFD software was used to analyze the conjugate heat transfer between the heat exchanger's tube and shell sides. Heat transfer characteristic like outlet temperature of shell and tube are investigated along with pressure drop on shell and tube side. Based on CFD results of double pipe heat exchanger with helical baffle on both shell side and tube side (Type 4) gives the better results than the other type of heat exchangers with an increased pressure drop than the others, results reveals that Type 4 outlet temperature of shell side is 8% higher and on tube side it is 5.5% higher, also pressure drop on shell side is 12% higher and on tube side it is 42% higher than the other types.
Possible Involvement of Adipose Tissue in Patients With Older Age, Obesity, and Diabetes With SARS-CoV-2 Infection (COVID-19) via GRP78 (BIP/HSPA5): Significance of Hyperinsulinemia Management in COVID-19
Authors: Shin Jihoon , Toyoda Shinichiro , Nishitani Shigeki , Fukuhara Atsunori , Kita Shunbun , Otsuki Michio , Shimomura Iichiro
Published: October 2021

Aging, obesity, and diabetes are major risk factors for the severe progression and outcome of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection (coronavirus disease 2019 [COVID-19]), but the underlying mechanism is not yet fully understood. In this study, we found that the SARS-CoV-2 spike protein physically interacts with cell surface GRP78, which promotes the binding to and accumulation in ACE2-expressing cells. GRP78 was highly expressed in adipose tissue and increased in humans and mice with older age, obesity, and diabetes. The overexpression of GRP78 was attributed to hyperinsulinemia in adipocytes, which was in part mediated by the stress-responsive transcription factor XBP-1s. Management of hyperinsulinemia by pharmacological approaches, including metformin, sodium–glucose cotransporter 2 inhibitor, or β3-adrenergic receptor agonist, decreased GRP78 gene expression in adipose tissue. Environmental interventions, including exercise, calorie restriction, fasting, or cold exposure, reduced the gene expression of GRP78 in adipose tissue. This study provides scientific evidence for the role of GRP78 as a binding partner of the SARS-CoV-2 spike protein and ACE2, which might be related to the severe progression and outcome of COVID-19 in patients with older age, obesity, and diabetes. The management of hyperinsulinemia and the related GRP78 expression could be a therapeutic or preventative target.
OPTIMASI ALUR PASAK DENGAN VARIASI FILLET DAN CHAMFER UNTUK MENINGKATKAN KEKUATAN POROS AISI 1045
Authors: Suryono Edy , Darmaatmadja Nikolaus Wignyo , Margono Bambang
Published: October 2021

Alur pasak adalah tempat atau slot dimana pasak dipasangkan atau diletakkan sesuai dengan bentuk pasak. Pasak jenis sunk key merupakan salah satu pasak yang paling umum dipakai. Dalam rangka mengoptimalkan kekuatan penguncian pasak dengan tetap mempertahankan kekuatan poros yang optimal maka perlu dilakukan penelitian. Penelitian dengan memodifikasi desain alur pasak dengan profil radius maupun chamfer. Penelitian ini dilakukan dengan memvariasikan ukuran radius dan chamfer sebesar 0.05 mm – 2.00 mm dengan range 0.05 dan 0.25 pada alur pasak. Material poros yang diteliti adalah AISI 1045 steel dengan tegangan geser yang diijinkan sebesar 625 MPa. Metode yang digunakan adalah analisis statis pada poros dengan beban torsi. Parameter simulasi meliputi analisis statis, beban berupa torsi sebesar 702.084 N/m2, ukuran mesh adalah standar fine dengan metode 4 jacobian points, ukuran elemen 4.697 mm dan toleransi 0.235 mm. Sedangkan mesh control pada bagian fillet dengan ukuran 1.174 mm.Hasil penelitian berupa rekomendasi profil alur pasak dengan radius 0.25 mm, dimana memiliki tegangan yang optimal sebesar 604.104 MPa, displacement sebesar 0.366 dan regangan sebesar 0.001. Poros beralur pasak dengan profil radius memiliki kekuatan lebih tinggi sebesar 2.299% dibandingkan poros alur pasak berprofil chamfer.
PANDANGAN MAHASISWA: PENTINGNYA KEMAMPUAN INFORMATION AND COMMUNICATION TECHNOLOGY (ICT) BAGI CALON GURU MATEMATIKA
Authors: Wulandari Nourma Pramestie , Novitasari Dwi , Junaidi Junaidi , Baidowi Baidowi
Published: October 2021

The demands of education in the Industrial Revolution 4.0 era require teachers to adapt to the development of digital technology. Capability in the field of Information and Communication Technology (ICT) is an important thing that must be mastered. The purpose of this study was to show the views of pre-service mathematics teacher students on the importance of ICT ability in making an ICT-based learning media. This research is a quantitative descriptive study conducted at a university in West Nusa Tenggara, Indonesia. The subjects were 146 second-year students who had attended the Mathematics Learning Media Development course. Subjects were given a questionnaire about ICT ability and ICT-based learning media. The data were analyzed by descriptive statistics. The results showed that 78.1% of students were interested in deepening their ability to make ICT-based learning media. Students have the view that it is very important for prospective mathematics teachers to master the field of ICT so that they can make learning interesting, not monotonous, and can eliminate students' negative perceptions of mathematics.
PEMBELAJARAN DARING MATEMATIKA BERBANTUAN GOOGLE CLASSROOM DITINJAU DARI GAYA BELAJAR PADA MASA PANDEMI
Authors: Subekti Yunti fahrulia
Published: October 2021

The purpose of the study was to determine the differences in mathematics learning outcomes and the effectiveness of google classroom-assisted learning in terms of learning styles on students' mathematics learning outcomes. This research used an experimental research method with a randomized pretest-posttest control group design. Sampling using a simple random sampling technique. The population of this research is the seventhgrade students of one of the public junior high schools in Sleman. The sample of this study amounted to 54 students consisting of class VII C and VII D. The data collection techniques used in this study were tests and questionnaires. The data analysis techniques used in this study were normality test, homogeneity test, similarity test, and hypothesis testing. The results of the study show that: (1) there are differences in learning outcomes in bold learning assisted by google classroom; (2) bold learning assisted by google classroom is more effective in terms of visual learning styles; (3) bold learning assisted by google classroom is not more effective in terms of auditory and kinesthetic learning styles.
KETIDAKADILAN DALAM PUISI “TANAH AIR MATA” KARYA SUTARDJI CALZOUM BAHRI
Authors: Susilowati Yuni
Published: October 2021

Puisi merupakan suatu karya sastra yang sering digunakan untuk penggambaran kondisi lingkungan maupun keadaan pengarang sendiri. Penggambaran yang diungkapkan dan dikemas dalam puisi dengan pemilihan diksi dan makna yang sangat mendalam. Puisi “Tanah Air Mata” karya Sutardji Calzoum Bahri memaparkan kondisi daerah Riau yang terjadi ketidakadilan antara pemerintah dan masyarakat setempat. Peneliti mengangkat rumusan masalah, Bagaimana bentuk-bentuk ketidakadilan dalam puisi “Tanah Air Mata” karya Sutardji Colzoum Bahri?. Adapun tujuan dalam penelitian ini untuk mengetahui bentuk-bentuk ketidakadilan yang terkandung dalam puisi “Tanah Air Mata” karya Sutardji Calzoum Bahri serta implikasinya pada kehidupan di era saat ini. Penelitian ini menggunakan penelitian kualitatif dengan analisis deskriptif dengan pendekatan sosiologi sastra. Penelitian ini dikuatkan dengan teori hegemoni yang di gagas oleh Antonio Gramsci. Sumber data penelitian ini adalah puisi “Tanah Air Mata” karya Sutardji Calzoum Bahri. Hasil penelitian ini adalah terdapat bentuk ketidakadilan yang ada dalam puisi “Tanah Air Mata” karya Sutardji Calzoum Bahri. Bentuk ketidakadilan dalam puisi “Tanah Air Mata” karya Sutardji Calzoum Bahri meliputi bentuk ketidakadilan marginalisasi, subordinasi, dan dominasi.
ANALISIS TEKS ARGUMENTASI DALAM TAJUK RENCANA HARIAN KOMPAS
Authors: Shalatun Raisah
Published: October 2021

Penelitian ini bertujuan untuk menjelaskan tentang argumentasi dalam tajuk rencana harian Kompas. Penelitian ini menggunakan pendekatan metode deskriptif. Penelitian ini menghasilkan dua kesimpulan, yaitu metode argumentasi yang digunakan dalam harian KOMPAS berupa (1) genus atau definisi, (2) sebab akibat, (3) sirkumstansi atau keadaan, (4) persamaan, (5) perbandingan, (6) penentangan, (7) kesaksian dan autoritas. Dalam satu tajuk rencana tidak hanya ditemukan satu Teknik argumentasi, namun dapat lebih dari satu Teknik argumentasi.
Pola argumentasi yang digunakan dalam tajuk rencana harian KOMPAS terdiri dari beberapa komponen. Komponen dari argument yang ditemukan antara lain (1) pernyataan posisi, (2) data, (3) jaminan, (4) pendukung, (5) keterangan modalitas, dan (6) pengecualian atau bantahan. Pola argumentasi yang ditemukan pada tajuk rencana harian Kompas antara lain adalah PP-D (pernyataan posisi, data), PP-D-K (pernyataan posisi, data, keterangan), PP-D-J (pernyataan posisi, data, jaminan), PP-D-J-B (pernyataan posisi, data, jaminan dan bantahan), PP-D-J-P-K-B (pernyataan posisi, data, jaminan, pendukung, keterangan dan bantahan).
KEYWORDS: argumentasi, tajuk rencana, harian kompas
NILAI SOSIAL DALAM NOVEL YOGYAKARTA KARYA DAMIEN DEMATRA DAN RELEVANSINYA SEBAGAI MATERI AJAR DI SMA: KAJIAN SOSIOLOGI SASTRA
Authors: Yani Fitri
Published: October 2021

Penelitian ini dilatarbelakangi oleh lunturnya nilai-nilai sosial dikalangan generasi muda atau kalangan pelajar. Tujuan pembuatan skripsi untuk: Mendeskripsikan kajian nilai sosial. Penelitian ini merupakan penelitian kualitatif. Penelitian ini mendeskripsikan nilai-nilai sosial dalam novel Yogyakarta karya Damien Dematra. Hasil analisis nilai sosial dalam novel Yogyakarta karya Damien Dematra ditemukan 26 data yang dikelompokan menjadi delapan aspek, yaitu aspek nilai pengabdian, nilai tolong-menolong, nilai kekeluargaan,nilai kesetiaan, nilai kepedulian, nilai disiplin, seta nilai empati. Penelitian ini direlevansikan sebagai materi ajar di Sekolah Menengah Atas pada materi novel kelas XII Kompetensi Dasar (KD)
Kata Kunci: Nilai sosial, Novel, Materi Ajar.
Yiyecek ve İçecek Hizmeti Sunan İşletmelerin Evcil Hayvan Politikalarının Analizi: Çeşme Örneği
Authors: Türksoy Selcen Seda
Published: October 2021

Yiyecek ve içecek hizmetlerinin sunulduğu restoran, kafe vb. işletmelere evcil hayvanların kabulü ile ilgili farklı düzenlemeler mevcuttur. Bazı işletmeler hayvan dostu politikalar benimseyerek kedi ya da köpek sahibi müşterileri kabul ederken bazıları ise tam tersi yönde uygulamalarla bu hayvanların işletmeye kabulünü kısıtlamaktadır. Hayvan dostu işletmelerin tutumları bile işletmeden işletmeye farklılık göstermektedir. Ayrıca işletmenin kontrolünde olmayan işletmenin sınırları içinde beslenen ve konuşlanan sahipsiz hayvanlar da bulunmaktadır. Kedi ya da köpeği bulunan misafirleri kabul eden işletmelerin evcil hayvan sahibi olmayan müşterilere de hizmet verdiği düşünüldüğünde işletmenin bu konuda nasıl bir politika izlemesi gerektiği kritik bir öneme sahiptir. Bu çalışma, işletmelerin restoran ve kafelerdeki kedi-köpeklere ve sahipsiz hayvanlara karşı mevcut tutumlarını araştırırken yiyecek ve içecek işletme sahiplerinin evcil hayvan politikası oluşturma sürecine de rehberlik etmeyi hedeflemektedir. Etkili, uygulanabilir ve açık bir evcil hayvan kabul politikası, kedi-köpek dostu yiyecek ve içecek işletmeleri için de bir gerekliliktir. Çalışmada nitel araştırma yaklaşımı benimsenmiştir. Araştırmanın örneklemini Çeşme ilçesinde bulunan farklı kategorideki onaltı yiyecek ve içecek işletmesi oluşturmaktadır. Yüzyüze yapılan görüşmelerden elde edilen görüşler betimsel analiz yardımıyla yorumlanmıştır. Araştırmaya katılan işletmelerin büyük bölümü değişen tüketici eğilimlerine bağlı olarak kendi insiyatifleri ölçüsünde evcil hayvan kabul etse de bu konuya ilişkin yerel ve ulusal ölçekte düzenlemelere ihtiyaç duyulmaktadır. Araştırma sonuçları işletmelerin politika oluşturma sürecine de ışık tutacaktır.