bluuebunny/crossref_metadata_2025 huggingface dataset:
Measuring and Addressing Territorial Cohesion: A Framework for Regional Development in Portugal
Authors: Chamusca Pedro
Published: January 2025

This study develops an innovative framework to assess territorial cohesion by integrating six critical dimensions: demography, equity, competitiveness, governance, sustainability, and connectivity. Rooted in the context of Portugal, the research addresses significant spatial disparities between metropolitan and inland regions, emphasizing the necessity of place-based policies. Using publicly available data and employing normalization techniques, the methodology ensures fair comparisons across municipalities with diverse characteristics. The findings highlight profound asymmetries, including demographic decline, unequal access to services, and variations in economic and governance performance. These results underscore the need for targeted interventions that align with the unique attributes and challenges of different territories. By incorporating governance and connectivity dimensions, the study advances traditional approaches to territorial cohesion, offering a holistic analytical model. The framework provides practical tools for policymakers to design interventions aimed at fostering balanced and sustainable development. Furthermore, its adaptability ensures relevance in varied contexts, enabling replication in other regions facing similar challenges. The study’s conclusions highlight the importance of addressing territorial disparities through integrated policies that enhance equity, sustainability, and resilience, contributing to the global discourse on regional development and public policy design.
Diet, DNA and the Mesolithic−Neolithic Transition in Western Scotland
Authors: Pickard Catriona , Greenberg Elizabeth , Smith Emma , Barlow Andy , Bonsall Clive
Published: January 2025

In this paper, we revisit the Mesolithic–Neolithic transition in western Scotland and the links between Early European farmers and middens in light of new aDNA, radiocarbon, and stable isotopic evidence. New carbon and nitrogen stable isotopic data for food sources (plant and animal remains) from a Mesolithic site are presented, and dietary FRUITS models are recalculated based on these data. We also respond to recent criticisms of the Bayesian approach to diet reconstruction. Results support the view that Neolithic people had at most a minimal contribution of marine foods in diet and also point to a dual population model of transition in western Scotland. A significant aspect of the transition in coastal western Scotland is the co-occurrence of Neolithic human remains with shell-midden deposits, which appears to contradict stable isotopic evidence indicating a minimal contribution of marine resources to the diet of early farming communities in the region. Finally, we highlight the need for further research to fully address these issues, including 1) targeted isotopic analyses of potential plant and animal resources, 2) single-entity radiocarbon and ZooMS analyses of animal bones and artefacts from shell-middens, and 3) further aDNA analyses of the remains of Late Mesolithic and Neolithic people.
Enhanced Matched Filtering for Investigating Eye Diagrams in Baseband Binary Transmission
Authors: Giannakopoulos Georgios , Adegbenro Peter , Perez Maria Antonnette
Published: January 2025

The aim of this paper is to study the performance of a matched filter for baseband binary transmission when subjected to Gaussian noise. A BER performance simulation model is created which consists of a BPSK encoder, a transmission SQRC filter, a Gaussian noise generator, a receive SQRT filter and a BPSK decoder. A Monte Carlo simulation technique is used to determine the dependency of BER performance on the signal to noise ratio. A MATLAB program and a MATLAB SIMULINK program was written to generate the required data. The MATLAB results show good agreement with statistical theoretical predictions.
PENGEMBANGAN WEB SERVICE SISTEM INFORMASI SKRIPSI DENGAN METODE SCRUM UNTUK PROGRAM STUDI PENDIDIKAN TEKNIK INFORMATIKA DAN KOMPUTER UNIVERSITAS NEGERI JAKARTA
Authors: M. Syafiq Roikhan Maulana  , Hamidillah Ajie  , Widodo
Published: January 2025

Skripsi menjadi syarat kelulusan mahasiswa Program Studi Pendidikan Teknik Informatika dan Komputer (PTIK) Universitas Negeri Jakarta (UNJ). Skripsi sebagai sarana penelitian yang dilakukan mahasiswa dengan bimbingan dosen dengan harapan hasil penelitian memiliki kualitas tinggi sehingga dapat diterapkan di lingkungan Program Studi PTIK. Saat ini, pengelolaan semua tahapan administratif skripsi masih dilakukan secara manual oleh admin program studi. Belum adanya sistem terintegrasi yang membantu keseluruhan proses administratif pelaksanaan skripsi, sehingga muncul sejumlah kendala. Selain itu, kebutuhan informasi yang berkaitan dengan skripsi tidak hanya dibutuhkan untuk kelulusan mahasiswa saja, tetapi sewaktu-waktu dibutuhkan untuk sistem yang lain. Sehingga dibutuhkan perangkat lunak layanan sistem informasi skripsi yang dapat memberikan informasi ke berbagai sistem yang didukung. Tujuan dari penelitian ini adalah untuk menghasilkan Web Service yang dapat digunakan untuk mengembangkan Sistem Informasi Skripsi untuk Program Studi PTIK UNJ  yang memiliki sifat adaptif terhadap perubahan yang perlu dilakukan di masa mendatang. Pengembangan dilakukan menggunakan Metode Scrum, bahasa pemrograman yang digunakan adalah javascript, dibantu dengan framework ExpressJS, dan menghasilkan 69 endpoint. Pengujian dilakukan pada seluruh endpoint dengan menggunakan metode Unit Testing dengan bantuan tools Postman. Hasil pengujian menunjukan bahwa endpoint berfungsi dengan baik dan layak digunakan sebagai sisi backend dari Sistem Informasi Skripsi Program Studi PTIK UNJ.
PENGARUH PENAMBAHAN EPOKSI PRIMER TERHADAP LAJU KOROSI BAJA KARBON RENDAH YANG DIRENDAM DALAM LARUTAN KAPORIT (KALSIUM HIPOKLORIT) YANG BERSIRKULASI
Authors: Eka Putra Ismet , Wardianto Dedi , Aulia Joni
Published: January 2025

Larutan kaporit, biasanya digunakan sebagai zat disinfektan air, yang dapat menyebabkan korosi logam. Larutan yang bersirkulasi dapat menggerus lapisan pelindung sehingga mempercepat korosi. Epoksi primer memberikan karakter pencegah karat dan daya lekat yang paling baik dibanding dengan cat primer jenis lain. Penelitian ini bertujuan untuk menguji pengaruh epoksi primer terhadap laju korosi baja karbon rendah yang direndam dalam larutan kalsium hipoklorit yang bersirkulasi. gtolPenelitian ini dilakukan dengan menggunakan 27 buah spesimen dalam 3 bejana masing – masing bejana terdapat 9 spesimen dengan perendaman baja karbon rendah tanpa perlakuan, yang dilapisi cat dan dilapisi epoksi primer. Volume larutan kaporit1 liter untuk 1 bejana. Hasil penelitian ini menunjukkan bahwa yang dilapisi epoksi primer mampu menghambat laju korosi dengan baik. Pengurangan berat baja karbon rendah yang tanpa perlakuan atau yang tidak dilapisi apapun jauh lebih besar dibandingkan pada baja karbon rendah yang dilapisi cat dan dilapisi epoksi primer meski begitu yang dilapisi cat tetap tidak mampu menahan laju korosi dengan baik. Laju korosi terendah dengan pemberian epoksi primer dalam waktu perendaman 60 hari dengan nilai rata – rata yaitu  0,002879872 mpy dan laju korosi tertinggi dengan tanpa perlakuan atau yang tidak dilapisi perlakuan sama sekali dalam waktu prendaman 15 hari dengan nilai rata – rata yaitu 0,009015251 mpy.
Evolución de las tasas de mortalidad por cáncer colorrectal en América Latina y el Caribe: Un análisis basado en la población entre 1997 al 2020
Authors:   , Blas Dolores Lisbeth Milagros
Published: January 2025

Antecedentes:
El cáncer colorrectal (CC) es la segunda causa principal de muerte y el tercer tipo de cáncer más común a nivel mundial. En América Latina, el CC ocupa el cuarto lugar entre la población masculina y el tercer lugar en la población femenina. A pesar de esto, pocos estudios han explorado de manera integral la evolución de la mortalidad por esta enfermedad en la región. Por esta razón, nuestro objetivo fue determinar la evolución de las tasas de mortalidad por CC durante los años 1997 a 2020 en los países de América Latina y el Caribe (ALC).

Métodos:
Se obtuvieron los datos de fallecimientos a través de la base de datos de la Organización Mundial de la Salud (OMS) desde 1997 hasta 2020. Se calcularon las tasas de mortalidad y los cambios porcentuales anuales utilizando el programa Joinpoint Regression.

Resultados:
Siete de los países de ALC (Brasil, Chile, Ecuador, Colombia, Perú, Paraguay y la República Dominicana) mostraron aumentos significativos en las tasas de mortalidad por CC; sin embargo, Argentina y Uruguay experimentaron disminuciones significativas en las tasas entre todos los hombres y mujeres, respectivamente. Según los grupos de edad, se observó que para las mujeres de 50 a 74 años, Uruguay disminuyó en un -1,3% entre 1997 y 2020. Por otro lado, Argentina (-1,1% en hombres y -1,3% en mujeres) y Panamá (-1,6% en hombres y -1,5% en mujeres) mostraron disminuciones significativas en ambos sexos mayores de 75 años. En Argentina, la tasa de mortalidad en hombres disminuyó un -1,1% y en mujeres un -1,3%, mientras que en la población de Panamá, la tasa en hombres disminuyó un -1,6% y en mujeres un -1,5%...
TrimNN: Characterizing cellular community motifs for studying multicellular topological organization in complex tissues
Authors: Wang Juexin , Yu Yang , Wang Shuang , Li Jinpu , Yu Meichen , McCrocklin Kyle , Ma Anjun , Ma Qin , Xu Dong , Kang Jing-Qiong
Published: January 2025

The spatial arrangement of cells plays a pivotal role in shaping tissue functions in various biological systems and diseased microenvironments. However, it is still under-investigated of the topological coordinating rules among different cell types as tissue spatial patterns. Here, we introduce the Triangulation cellular community motif Neural Network (TrimNN), a bottom-up approach to estimate the prevalence of sizeable conservative cell organization patterns as Cellular Community (CC) motifs in spatial transcriptomics and proteomics. Different from clustering cell type composition from classical top-down analysis, TrimNN differentiates cellular niches as countable topological blocks in recurring interconnections of various types, representing multicellular neighborhoods with interpretability and generalizability. This graph-based deep learning framework adopts inductive bias in CCs and uses a semi-divide and conquer approach in the triangulated space. In spatial omics studies, various sizes of CC motifs identified by TrimNN robustly reveal relations between spatially distributed cell-type patterns and diverse phenotypical biological functions.
Cation-controlled diffusion of chloride ions during electrochemical chlorine evolution in acidic media
Authors: Nakamura Ryuhei , Lim Taejung , Ooka Hideshi
Published: January 2025

Impurity ions pose a major challenge towards diversifying water usage for electrolysis. In particular, millimolar-level chloride impurities remaining in reverse osmosis filtrates significantly diminish the selectivity and longevity of water electrolyzers. Here, we show that alkali metal cations can regulate the diffusion coefficient of chloride ions, enabling suppression of chlorine evolution during water electrolysis under diffusion-limiting conditions. Evidence of the cation dependency is provided by positive intercepts in both Levich and modified Koutecký−Levich plots using a rotating ring disk electrode, indicating the presence of an additional, cation-dependent diffusion layer that suppresses chloride diffusion. Numerical simulations based on the double diffusion model quantify this effect, resulting in a linear correlation between the cation-dependent diffusion barrier and the structural entropy of cation hydration. These findings suggest that the cation-dependent structuring of water significantly influences mass transport, which is particularly important at practical current densities where impurity ions are diffusion-limited.
The Effect of Pseudoallergen Consumption on Skin Bioelectrical Impedance Parameters in Children Diagnosed with Urticaria
Authors: Alkaya Halil , Altaş Uğur , Çevik Seda , Altaş Zeynep Meva , Vazgeçer Ebru Oğultekin , Özkars Mehmet Yaşar
Published: January 2025

Introduction:Acut idiopathic urticaria is a common dermatologic condition that can significantly impact a patient's quality of life. Studies suggest various factors, including allergic and non-allergic triggers, play a role in the disease's development. However, the effects of lifestyle factors such as food consumption on disease activity and skin characteristics remain insufficiently studied.
Objective:This study aimed to evaluate the relationship between symptom duration, urticaria activity at admission, weekly packaged food consumption, and skin measurements (moisture, oil, and softness) in patients with acute idiopathic urticaria (AIU).
Material and Methods: This case-control study included 25 patients with AIU and a control group of 25 healthy children. Clinical data, including symptom duration, urticaria activity score (UAS), and weekly packaged food consumption, were collected. Skin measurements, such as moisture (MOIST %), oil, and softness, were assessed at admission. Correlations between these factors were analyzed using Pearson's correlation coefficient.
Results:The study found significant negative correlations between weekly packaged food consumption and skin moisture (R=-0.405, P=0.041), oil (R=-0.421, P=0.032), and softness (R=-0.463, P=0.016). There was no significant correlation between symptom duration, UAS, and skin measurements.
Conclusion:The results suggest that higher consumption of packaged foods correlates with decreased skin hydration and oiliness in children with AIU. Further studies are needed to understand the underlying mechanisms and to explore the impact of diet on chronic skin conditions.
High alpha-band activity of prefrontal cortex contributes to the significant neural alterations in the initial two-month phase of a romantic relationship
Authors: Zhang Zhizhen , Han Chuanliang
Published: January 2025

Romantic relationships are integral to human experience, with most individuals encountering them at some point in their lives. The neural mechanisms of romantic relationships have gradually gained attention. However, existing studies have mainly focused on the cross-sectional level, and longitudinal research is not sufficient, especially regarding the early stages when couples first enter a romantic relationship. The brain's neural transition from a normal state to the honeymoon phase of love remains poorly understood. To answer this question, we, the authors, used ourselves as subjects; after confirming our romantic relationship, we employed portable electroencephalography (EEG) to record neural activity in the prefrontal cortex during resting states (both with eyes open and closed). Data collection occurred irregularly over a period of around two months, resulting in 13 EEG data trials per individual. We found that there was a consistent decrease in the high alpha band neural activity under the closed-eye state for both of us over the two-month period, suggesting a potential correlation with the neural activity changes in the early stage of the romantic relationship. Further analysis revealed that this decrease was driven by changes in periodic components rather than non-periodic components. This study is the first to reveal a significant change in the alpha oscillatory activity of the prefrontal cortex in a couple during the initial two months after confirming their romantic relationship, which will further impact the understanding of the mechanism of alpha sub-oscillations and their application in the study of emotions process.
Variations in iron profile among dialysis adherent chronic kidney disease patients and compare with the non-adherence chronic kidney disease patients
Authors: Ogolla Collince Odiwuor , Karani Lucy W. , Musyoki Stanslaus , Maruti Phidelis
Published: January 2025

Background:Chronic kidney disease (CKD) constitutes one of the most important global health challenges and iron deficiency (ID) anemia are both frequent complications, especially in patients on dialysis. Dialysis treatment is an important aspect of addressing these complications, yet the treatment adherence rate is low in CKD patients and the association between dialysis adherence and differences in iron profiles among CKD patients is unclear.
Objectives: This study aimed to assess differences in iron profile in dialysis-adherent and non-adherent chronic kidney disease subjects and analyze the profiles between both groups.
Methods: One hundred twenty patients undergoing hemodialysis were included in this cross-sectional study, divided into two groups based on two subcategories of dialysis adherence- adherent (n=60) and nonadherent (n=60). The parameters of iron profile-also defined as serum ferritin, transferrin saturation (TSAT), hemoglobin, and serum iron-were studied. Further, multivariate regression analysis was carried out, adjusting possible confounders such as age, sex, diabetes, and duration of dialysis. Results: Serum ferritin was significantly higher among patients in the adherent group when compared with those in the non-adherent group (235.6 120.2 ng/mL vs. 185.2 105.3 ng/mL; p=0.03), TSAT (33.4 9.3% vs. 28.8 10.2%; p=0.02), and hemoglobin level (11.5 1.8 g/dL vs. 10.2 2.1 g/dL; p=0.04). That is, non-adherence to the therapy was associated with a significantly higher number of patients having iron deficiency anemia (63% in non-adherent vs. 40% in adherent patients; p=0.01). Multivariate analysis confirmed that dialysis adherence was independently associated with better iron status (p<0.05 for all parameters).
Conclusion:In hemodialysis patients, adherence to dialysis presents as a strong predictor of better iron profile. More "iron parameters" were better and showed a decreased reliance on iron deficiency anemia for adherents. Such improvement, however, may significantly reduce anemia-associated complications through strategies that improve adherence to dialysis treatment by optimizing iron metabolism among chronic kidney disease patients.
Identification of the nature of recycled carbonates in the mantle: Insights from Mo-Mg isotopic pair
Authors: Lei Ming , Guo Zhengfu , Dingwell Donald B. , Li Jie , Chen Jianlin
Published: January 2025

It is generally accepted that carbon from Earth’s surface can be recycled into the mantle during oceanic subduction, thereby playing an important role in the global carbon cycle. However, evidence as to whether the mantle contains recycled carbonates, and of which types, remains ambiguous. Here, we present Mo-Mg isotopic data for two distinct mafic rock types in the Lhasa terrane, southern Tibet: the Taruocuo gabbros and Zhongba basalts. These units were formed in response to Neo-Tethys oceanic subduction at the sub-arc and post-arc depths of the mantle, respectively. Our results, combined with existing data, show that the Late Cretaceous (ca. 90 Ma) Taruocuo gabbros with arc-like geochemical characteristics (e.g., Nb–Ta depletions) have high δ98/95Mo (0.19‰ to 0.61‰) and mantle-like δ26Mg (−0.29‰ to −0.22‰) values. In contrast, the Early Cenozoic (ca. 52 Ma) Zhongba basalts with ocean island basalt-like geochemical signatures (e.g., Nb–Ta enrichments) have low δ98/95Mo (−0.66‰ to −0.24‰) and δ26Mg (−0.38‰ to −0.30‰) values. Neither shallow processes (e.g., alteration, crustal contamination, and fractional crystallization) nor partial melting can explain the Mo-Mg isotopic features of the Taruocuo gabbros and Zhongba basalts. Thus, we infer that the Mo-Mg isotopic features of the Taruocuo gabbros and Zhongba basalts may well reflect their source characteristics. We argue that the Taruocuo gabbros were derived from a mantle source that contained recycled Ca-rich carbonates at the sub-arc depths. In contrast, the Zhongba basalts appear to have been derived from a mantle source containing recycled Mg-rich carbonates and some oceanic crust in the form of eclogite at the post-arc depths. Our findings suggest that recycled carbonate sediments at the sub-55 arc depths of the mantle may increase its δ98/95Mo values without significantly affecting δ26Mg values, whereas recycled carbonate sediments at the post-arc depths of the mantle would decrease both δ98/95Mo and δ26Mg values. Therefore, the Mo-Mg isotopic pair may be a unique tool for determining whether the mantle contains recycled carbonates and for identifying the types of carbonates involved during oceanic subduction.
Pleiotropic effects of osteoarthritis therapy
Authors: Filatova Yu. S. , Yaltseva N. V. , Leontieva E. A.
Published: January 2025

The article discusses the problem of osteoarthritis, its increasing prevalence and high comorbidity. The data on the effect of osteoarthritis on the course of comorbid conditions, as well as the influence of a number of common diseases, such as hypertension on the development of osteoarthritis, are presented. In matters of therapy, data are provided on the effectiveness of the use of glucosamine, chondroitin sulfate and diacerein. The article presents the results of studies demonstrating the pleiotropic properties of these molecules. Thus, the most important pleiotropic effects of glucosamine include a preventive role in the development of atherosclerosis, an effect on reducing the risk of general cardiovascular events by 15% and the risk of individual cardiovascular events by 9–22%. Glucosamine intake is also associated with a reduced risk of lung cancer and mortality from lung cancer. The results of large cohort studies demonstrated that glucosamine use was associated with a 17% reduction in the risk of developing DM2, as well as a lower risk of developing gout in women and a lower risk of developing dementia. The use of chondroitin sulfate increased the bone mineral density of rats with diabetes mellitus, and also relieved the symptoms of hyperglycemia, polydipsia and polyphagia caused by diabetes in rats. The article also presents the results of a study that demonstrated significant inhibition of HCT-116 xenograft tumor development in mice by suppressing proliferation and inducing apoptosis while taking chondroitin sulfate. In other studies, it has demonstrated the ability to reduce oxidative stress and increase the amount of antioxidants that are important for neuroregeneration. The use of diacerein helps to increase insulin secretion and improve metabolic control in patients with type 2 diabetes mellitus. Thus, regular intake of glucosamine, chondroitin sulfate and diacerein can affect comorbid conditions, improving their course, as well as reduce cardiovascular risks.
ESPAÇOS URBANOS PARA VIVER E CONVIVER
Authors: Macedo Adilson
Published: January 2025

'Tenho ideias como um cidadão-arquiteto e as vezes elas chegam à realidade”, poderia ser este o subtítulo do ensaio. O plano, o projeto urbano, o projeto de arquitetura, associados a procedimentos adequados de implementação viabilizam ideias. Como profissional desejo que tudo aconteça e trago exemplos de como espaços resultantes de um bom entendimento da realidade, podem se tornar lugares para pessoas. Meu trabalho profissional se modificou desde quando percebi que os requisitos do cliente não podem ser respondidos abstratamente. Por exemplo, inventar artifícios para justificar a resolução do programa do cliente em um bloco único ou concebido como um objeto de arte. Participei de projetos com programas de implantação complexos e daí procurei entender como as pessoas e coisas se deslocam, podem organizar o espaço comum e ter gosto pelo refúgio privado. Enveredei -me para o projeto urbano, desde a teoria e o interesse para caminhar por trechos da cidade. Considerar o estudo dos espaços por partes, diferenciar os caminhos, os lugares de permanência, preservar o verde e a água. Vou mostrar alguns elementos necessários para facilitar o estudo da forma e projetar a cidade, o que tem sido muito da minha história.
A educação em tempos de transição
Authors: Santos Douglas Manoel Antonio de Abreu Pestana dos
Published: January 2025

No limiar de um mundo por nascer,
A educação, vigorosa e inquieta,
Tece seu canto, não se acomoda ao crepúsculo,
Mas acende a alvorada da certeza incerta.
Em tempos de transição, trama-se a história,
O velho cede espaço ao novo porvir,
E a educação, o mestre da trajetória,
Guiando mentes, faz o futuro existir.
Oh, tempo de incertezas e desafios!
Caminhamos por sendas não trilhadas,
Mas a educação, farol em nosso fio,
Nos guia com saberes bem alinhavados.
Despede-se o ontem com nostalgia,
Mas o amanhã, promissor e audaz,
Surge no olhar da educação, magia,
Que transforma o mundo em um sonho capaz.
A sala de aula, um palco de ensinamento,
Onde se encena a epopeia do saber,
E a educação, com amor e alimento,
Alça voos de sonhos por viver.
A transição é ponte, não é abismo,
É elo entre o que foi e o que virá,
E a educação, firme em seu lirismo,
Nos conduz à luz da nova era, já.
Assim, oh, educadores, bravos guerreiros,
Construtores do porvir que nos espera,
Levem consigo o facho dos pioneiros,
E iluminem o mundo com sua utopia.
A educação, bússola em nossas mãos,
Nos aponta o caminho da verdade,
E em tempos de transição, em corações,
É o farol que nos guia com claridade.
Caracterização higiênico-sanitária e socioambiental da pesca artesanal do Rio Apodi-Mossoró, RN
Authors:   , Morais Jefferson Alves de
Published: January 2025

O rio Apodi-Mossoró, onde ocorre à pesca artesanal, no município de Mossoró já apresenta sinais claros de problemas ecológicos, como poluição decorrente do lançamento de esgotos, diminuição de sua mata ciliar e assoreamento. Esse quadro de degradação ambiental se agrava ainda mais em virtude do elevado grau de contaminação da água na área do perímetro urbano de Mossoró. O objetivo principal de trabalho é avaliar os aspectos socioambientais da colônia Z-55 quanto ao Rio Apodi-Mossoró, RN. Para analisarmos a condição ambiental da água e dos peixes do Rio Apodi-Mossoró, foi feita a quantificação de coliformes totais e termotolerantes, Escherichia coli, bactérias mesófilas, Staphylococcus aureus e Salmonella sp., e as condições sociais foram avaliadas através de entrevistas com os pescadores da colônia. O presente estudo foi realizado no município de Mossoró-RN, mais precisamente no trecho do Rio Apodi-Mossoró que corta a zona urbana. Para as análises ambientais as coletas de água e peixe foram realizadas em seis pontos distintos georreferênciados de acordo com a metodologia de MacFaddin. Para as entrevistas sociais junto aos pescadores artesanais foi aplicado um questionário na sede da colônia Z-55, bem como nas casas dos pescadores e as margens do Rio Apodi-Mossoró. Os valores encontrados para as análises microbiológicas da água e do peixe se mostraram insatisfatórias, mostrando o quanto o rio se encontra impactado. De acordo com as respostas das entrevistas realizadas com os pescadores artesanais, temos como resultado a percepção ambiental compatível ao nível de poluição do Rio Apodi-Mossoró. Concluímos que o Rio Apodi-Mossoró necessita de um monitoramento ambiental mais aprofundado, pois se encontra com sua água e seu peixe com parâmetros microbiológicos fora dos padrões da legislação vigente, bem como, os pescadores artesanais pertencentes à colônia Z-55 tem a percepção de que o Rio Apodi-Mossoró se encontra poluído, porém desconhecem das principais doenças que essa poluição pode causar.
O Rio Mossoró e a educação ambiental na percepção de estudantes surdos
Authors:   , Souza Niascara Valesca do Nascimento
Published: January 2025

Esta pesquisa visa estimular comportamentos pró-ambientais em determinados grupos de pessoas surdas. Para a realização deste intento, é imprescindível conhecer o imaginário delas em relação às questões ambientais que fazem parte do seu cotidiano. Neste sentido, nosso trabalho teve o objetivo de verificar a representação social de alunos surdos regularmente matriculados nos Ensinos Fundamental, Médio e Superior da Rede Pública do Município de Mossoró, do Estado do Rio Grande do Norte sobre a poluição do Rio Mossoró e suas implicações na sua relação com o meio ambiente. Utilizamos como metodologia a pesquisa qualitativa, descritiva e exploratória sobre a questão ambiental do Rio Mossoró, por meio de aplicação de questionários junto aos estudantes surdos das instituições de ensino em questão. Após isso, foram criados sinais na Língua Brasileira de Sinais (LIBRAS) para a construção de um glossário pertinente à área de Ciências Ambientais. As análises dos dados foram tabuladas em planilha. Posteriormente, foi realizada estatística descritiva. A pesquisa apresentou resultados valiosos para educação de surdos no âmbito da Educação Ambiental ao criar e propor um léxico em LIBRAS, o que se mostrou imprescindível para que os surdos tivessem acesso em língua materna a conteúdos vitais para o desenvolvimento de comportamentos pró-ambientais no público pesquisado. No final da coleta de dados, analisamos as informações coletadas e percebemos que a maioria dos alunos surdos não tinha conhecimento das questões relativas ao meio ambiente e um dos motivos estava relacionado com a falta de um léxico especializado na LIBRAS. Por isso iniciamos o processo de criação e validação de 20 sinais os quais foram criados respeitando os aspectos linguísticos da LIBRAS e a demanda da Comunidade Surda local. Por fim, a compreensão de novos sinais permitiu possibilidades para que os discentes surdos tenham acesso às discussões atuais relacionadas ao meio ambiente, consequentemente tendo implicações positivas no âmbito escolar (ensino básico e superior) tanto na Educação Inclusiva, que facilita a comunicação entre professor-ouvinte-aluno surdo-interprete, quanto na Educação Bilíngue.
Advanced Targeted Therapy for Colorectal Cancer with Lipid Nanoparticles
Authors: Kedar Pawan , Bhattacharya Sankha , Sakore Preeti , Prajapati Bhupendra G.
Published: January 2025

Targeted therapy for colorectal cancer (CRC) appears to have great potential
with lipid nanoparticles (LNPs). The advances in LNP-based techniques, such as liposomes,
exosomes, micelles, solid lipid nanoparticles (SLNs), nano-cubosomes, and plant-
derived LNPs (PDLNPs), are explored in detail in this thorough review. Every platform
provides distinct advantages: liposomes enable precise drug release and improved
delivery; exosomes function as organic nanocarriers for focused treatment; SLNs offer
greater stability; micelles enhance drug solubility and resistance; nano-cubosomes tackle
low bioavailability; and PDLNPs offer biocompatible substitutes. The mechanisms, benefits,
drawbacks, and therapeutic potential of these LNP platforms in the treatment of
colorectal cancer are highlighted in the review. The review highlights how crucial it is to
use these technologies for efficient CRC management and looks at potential future developments
for them. The controlled release properties of liposomes and solid liposome
nanoparticles (SLNs) improve the stability and bioavailability of medicinal compounds.
On the other hand, exosomes and micelles provide answers for medication resistance
and solubility issues, respectively. Novel strategies for resolving bioavailability
problems and enhancing biocompatibility include nano-cubosomes and PDLNPs. These
LNP-based systems are promising in clinical applications for boosting therapeutic efficacy,
decreasing systemic toxicity, and facilitating tailored drug delivery. By incorporating
these nanotechnologies into CRC treatment plans, present therapeutic approaches may
be completely changed, and more individualized and efficient treatment choices may be
provided. To completely comprehend the advantages and drawbacks of these LNP systems
in therapeutic settings, as well as to and optimize them, more study is recommended
by the review. Treatment for colorectal cancer may be much improved in the future
thanks to developments in LNP-based drug delivery systems. These technologies hold
great promise for improving patient outcomes and advancing the field of oncology by
tackling important issues related to medication delivery and bioavailability.
Unraveling the Therapeutic Potential of Sophora flavescens Aiton in Myocardial Infarction: An Integrative Approach Combining Bioinformatics, Network Pharmacology, and Experimental Validation
Authors: Zhang Zhongbai , Tong Yang , Xie Hongwei , Jiang Mengting , Li Yanchun , Liang Chun
Published: January 2025

Aims:

This study aims to elucidate the relationship between potential MI targets and SFA’s mechanism
of action, providing a theoretical basis for clinical development of new drugs.

Background:

Myocardial infarction (MI) has been identified as one of the major cardiovascular diseases with
adverse consequences. Sophora flavescens Aiton (SFA) is indicated for the therapeutic treatment of MI. However,
there is no systematic research on the new therapeutic targets for MI and the exact action mechanism of
SFA.

Objective:

This study explores the potential mechanisms of SFA in treating MI by integrating bioinformatics,
network pharmacology analyses and experimental verification.

Methods:

New MI targets were predicted using bioinformatics techniques. Network pharmacology and molecular
docking jointly served for predicting the key targets and underlying mechanisms of SFA. A machine
learning model was developed to identify the core MI targets. Subsequently, H9c2 cardiomyocytes hypoxia
model was established for experimental verification.

Results:

140 active components were ascertained in SFA and 59 differentially expressed genes (DEGs) were
screened for MI. Eighty-seven shared genes were obtained by WGCAN. Eighty proteins and 413 interactions
were identified by PPI network. After building the machine model, three core targets were identified (STAT1,
TNFRSF1A and MCL1). According to in vitro experiments, SFA exerts a protective effect relying on three
core targets and biological processes, including cell viability, the inflammatory response, and antiapoptotic
effects, etc.

Conclusion:

This study finds new core targets for MI and the therapeutic activity of SFA against MI, of
which the experimental verification provides valuable insights into the molecular mechanisms underlying
SFA’s efficacy in MI treatment and paves the way for targeted drug development strategies.
Lutein and Zeaxanthin: Source, Extraction, Stability, Bioactivity, and Functional Food Applications
Authors: Pandey Surabhi , Gupta Akansha , Mahato Dipendra Kumar , Paul Veena , Tripathi Abhishek Dutt , Rasane Prasad , Kumar Pradeep , kamle Madhu , Haque Shafiul
Published: January 2025

Nature has been acknowledged as a fundamental source of diverse bioactive molecules.
Among natural carotenoids, lutein, zeaxanthin, and their oxidative metabolites are specifically
deposited in the macular region of living organisms. Lutein and zeaxanthin are carotenoids
primarily found in green leafy vegetables, eggs, and various fruits. Lutein and zeaxanthin
emerge as the primary carotenoids in the retina, playing a crucial role as photo-protectants
to prevent retinal degeneration. The extraction of lutein and zeaxanthin from natural sources
involves several techniques, including solvent extraction and supercritical fluid extraction,
with an emphasis on optimizing efficiency and yield. Incorporating these carotenoids into
functional foods—such as fortified dairy products, baked goods, and snacks—enhances their
nutritional profiles and provides significant health benefits. This review examines the sources,
stability, bioactivity, and various extraction methods for lutein and zeaxanthin, highlighting
their potential for photoprotection, antioxidant activity, and antidiabetic effects. These attributes,
combined with innovative extraction techniques, position lutein and zeaxanthin as promising
ingredients for functional food applications.
Recent Insights into the Potential Roles of Crocin and Safranal in Alleviating Skin Aging: A Mini-Review
Authors: Octavia Chitra , Gunadi Julia Windi , Adhika Oeij Anindita , Jasaputra Diana Krisanti , Samuel Lukas Mulyono , Rumanti Rizna Tyrani
Published: January 2025

Research has been carried out regarding the benefits and influence of saffron and its derivatives
on skin health. Crocin from Crocus sativus L., Gardenia jasminoides, and Nyctanthes arbor-
tristis, and safranal from Crocus sativus L. might alleviate skin aging effects. This literature
review discusses the mechanism of crocin and safranal as anti-inflammatory agents in reversing oxidative
stress and improving aging effects on the skin. Based on the literature review, crocin and safranal
have strong antioxidant capacity. The mechanism that allows crocin to reduce oxidative stress
is by directly neutralizing reactive oxygen species in human dermal fibroblasts and modifying
keratinocyte O-linked glycobiology in human keratinocytes. Crocin also increases skin thickness and
protects against blue light stress; its derivative, crocetin, could act like melatonin. Meanwhile, safranal
also has a potential mechanism for alleviating skin aging in the form of nanoparticles (liposome
and solid nanoparticles) or pure safranal through inhibiting dermal enzymes that are involved in the
process of skin aging, such as elastase, collagenase, and hyaluronidase.
Mapping research in Socio-pragmatic linguistics on food vloggers on YouTube: A bibliometric analysis
Authors: Rahman Fauzi , Rafli Zainal , Anwar Miftahulkhairah
Published: January 2025

The phenomenon of food vloggers sharing their culinary experiences through videos presents an interesting area for sociopragmatic studies. This research focuses on understanding the social interactions and pragmatic contexts within food vlogging content. Specifically, the study aims to map the development of sociopragmatic research on the YouTube platform in relation to food vlogging. Using qualitative methods and bibliometric analysis, this study identifies and analyzes publications related to sociopragmatics and food vlogging from electronic databases such as Web of Science, Scopus, and Google Scholar. Keywords such as "sociopragmatics," "food vlogging," and "YouTube" were used to gather relevant data. Bibliometric analysis was conducted using Publish or Perish and VOSviewer software, enabling the processing and visualization of data in this field. The findings indicate a growing interest in food vlogging as a research subject, although studies explicitly examining sociopragmatic aspects remain limited. These findings highlight opportunities for in-depth research on sociopragmatic aspects, such as the use of speech acts, politeness in language, vloggers' communication strategies, interactions between vloggers and viewers, the construction and negotiation of social identities in vlog content, and the reflection of cultural values and social norms in social media interactions, particularly on YouTube.
A Serious Game to Study Reduced Field of View in Keyhole Surgery: Development and Experimental Study
Authors: Whitley Phoebe , Creasey Connor , Clarkson Matthew J , Thompson Stephen
Published: January 2025

Background

During keyhole surgery, the surgeon is required to perform highly demanding tasks while only being able to see part of the patient’s anatomy. This limited field of view is widely cited as a key limitation of the procedure, and many computational methods have been proposed to overcome it. However, the precise effects of a limited field of view on task performance remain unknown due to the lack of tools to study these effects effectively.

Objective

This paper describes our work on developing a serious game with 2 objectives: (1) to create an engaging game that communicates some of the challenges of keyhole surgery, and (2) to test the effect of a limited field of view on task performance. The development of a serious game that can be played by a wide range of participants will enable us to gather quantitative data on the effects of the reduced field of view on task performance. These data can inform the future development of technologies to help surgeons reduce the impact of a limited field of view on clinical outcomes for patients. The game is open source and may be adapted and used by other researchers to study related problems.

Methods

We implemented an open-source serious game in JavaScript, inspired by the surgical task of selectively cauterizing blood vessels during twin-to-twin transfusion surgery. During the game, the player is required to identify and cut the correct blood vessel under different fields of view and varying levels of vascular complexity. We conducted a quantitative analysis of task performance time under different conditions and a formative analysis of the game using participant questionnaires.

Results

We recruited 25 players to test the game and recorded their task performance time, accuracy, and qualitative metrics. Reducing the field of view resulted in participants taking significantly longer (P<.001) to perform otherwise identical tasks (mean 6.4 seconds, 95% CI 5.0-7.8 seconds vs mean 13.6 seconds, 95% CI 10.3-16.9 seconds). Participants found the game engaging and agreed that it enhanced their understanding of the limited field of view during keyhole surgery.

Conclusions

We recruited 25 players to test the game and recorded their task performance time, accuracy, and qualitative metrics. Reducing the field of view resulted in participants taking statistically significantly longer (16.4 vs 9.8 seconds; P=.05) to perform otherwise identical tasks. Participants found the game engaging and agreed that it enhanced their understanding of the limited field of view during keyhole surgery.
Swedish Version of the System Usability Scale: Translation, Adaption, and Psychometric Evaluation
Authors: Åvik Persson Helene , Castor Charlotte , Andersson Nilla , Hylén Mia
Published: January 2025

Background

The Swedish health care system is undergoing a transformation. eHealth technologies are increasingly being used. The System Usability Scale is a widely used tool, offering a standardized and reliable measure for assessing the usability of digital health solutions. However, despite the existence of several translations of the System Usability Scale into Swedish, none have undergone psychometric validation. This highlights the urgent need for a validated and standardized Swedish version of the System Usability Scale to ensure accurate and reliable usability evaluations.

Objective

The aim of the study was to translate and psychometrically evaluate a Swedish version of the System Usability Scale.

Methods

The study utilized a 2-phase design. The first phase translated the System Usability Scale into Swedish and the second phase tested the scale’s psychometric properties. A total of 62 participants generated a total of 82 measurements. Descriptive statistics were used to visualize participants’ characteristics. The psychometric evaluation consisted of data quality, scaling assumptions, and acceptability. Construct validity was evaluated by convergent validity, and reliability was evaluated by internal consistency.

Results

The Swedish version of the System Usability Scale demonstrated high conformity with the original version. The scale showed high internal consistency with a Cronbach α of .852 and corrected item-total correlations ranging from 0.454 to 0.731. The construct validity was supported by a significant positive correlation between the System Usability Scale and domain 5 of the eHealth Literacy Questionnaire (P=.001).

Conclusions

The Swedish version of the System Usability Scale demonstrated satisfactory psychometric properties. It can be recommended for use in a Swedish context. The positive correlation with domain 5 of the eHealth Literacy Questionnaire further supports the construct validity of the Swedish version of the System Usability Scale, affirming its suitability for evaluating digital health solutions. Additional tests of the Swedish version of the System Usability Scale, for example, in the evaluation of more complex eHealth technology, would further validate the scale.
Development of an innovative digital cognitive and behavioral treatment for insomnia disorder in adults (dCBT-I) : a scoping review and framework development (Preprint)
Authors: Stern Emilie , Brune Severine , MOUCHABAC Stephane , Dubroc Anthony , de la Personne Charles , Geoffroy Pierre Alexis
Published: January 2025

BACKGROUND

Chronic insomnia, or insomnia disorder, is a major health issue with a prevalence of up to 15%. The recommended first-line treatment is cognitive and behavioral therapy for insomnia (CBTi), which, unfortunately, remains insufficiently accessible. Digitalization has the potential to reduce healthcare access inequalities by offering more flexible and accessible care options. Digital CBTi (dCBTi) has been shown to be as effective as in-person CBTi, highlighting its potential for broader implementation.

OBJECTIVE

This study aimed to develop an evidence-based dCBTi program grounded in theoretical and clinical knowledge, designed for efficient integration into healthcare systems, and to establish it as the first prescribed digital treatment in France

METHODS

The program was constructed based on validated CBTi theory and practice, incorporating the latest scientific data on CBT for insomnia. It was designed as a robust multicomponent therapy, integrating an initial standardized assessment and daily intelligent adaptation to enable digital phenotyping and provide personalized treatment.

RESULTS

We developed an innovative digital solution that combines scientific rigor with practical application. The program includes a standardized initial evaluation and dynamic personalization through intelligent algorithms. These features allow for the adaptation of therapy based on patient progress and needs, ensuring individualized care.

CONCLUSIONS

The development of this dCBTi program represents a significant milestone in digital healthcare, offering a scalable solution to the accessibility challenges of traditional CBTi. Future steps involve conducting clinical studies to further evaluate its effectiveness and optimize its implementation within healthcare systems.