bluuebunny/crossref_metadata_2025 huggingface dataset:
Biosynthesis of organic photosensitizer Zn-porphyrin by diphtheria toxin repressor (DtxR)-mediated global upregulation of engineered heme biosynthesis pathway in Corynebacterium glutamicum
Authors: Ko Young Jin , Joo Young-Chul , Hyeon Jeong Eun , Lee Eunhye , Lee Myeong-Eun , Seok Jiho , Kim Seung Wook , Park Chulhwan , Han Sung Ok
Published: September 2018

Zn-porphyrin is a promising organic photosensitizer in various fields including solar cells, interface and biomedical research, but the biosynthesis study has been limited, probably due to the difficulty of understanding complex biosynthesis pathways. In this study, we developed a Corynebacterium glutamicum platform strain for the biosynthesis of Zn-coproporphyrin III (Zn-CP III), in which the heme biosynthesis pathway was efficiently upregulated. The pathway was activated and reinforced by strong promoter-induced expression of hemAM (encoding mutated glutamyl-tRNA reductase) and hemL (encoding glutamate-1-semialdehyde aminotransferase) genes. This engineered strain produced 33.54 ± 3.44 mg/l of Zn-CP III, while the control strain produced none. For efficient global regulation of the complex pathway, the dtxR gene encoding the transcriptional regulator diphtheria toxin repressor (DtxR) was first overexpressed in C. glutamicum with hemAM and hemL genes, and its combinatorial expression was improved by using effective genetic tools. This engineered strain biosynthesized 68.31 ± 2.15 mg/l of Zn-CP III. Finally, fed-batch fermentation allowed for the production of 132.09 mg/l of Zn-CP III. This titer represents the highest in bacterial production of Zn-CP III reported to date, to our knowledge. This study demonstrates that engineered C. glutamicum can be a robust biotechnological model for the production of photosensitizer Zn-porphyrin.
In situ heating TEM observations on carbide formation and α-Fe recrystallization in twinned martensite
Authors: Liu X. , Man T. H. , Yin J. , Lu X. , Guo S. Q. , Ohmura T. , Ping D. H.
Published: September 2018

The microstructural evolution of twinned martensite in water-quenched Fe–1.6 C (wt.%) alloys upon in situ heating was investigated using transmission electron microscopy (TEM). In the as-quenched samples, a high density of a body-centred cubic (bcc) {112} 〈111〉 -type twinning structure exists in the martensite structure. Upon in situ heating to approximately 200–250 °C, carbides (mainly θ-Fe3C cementite) accompanying a detwinning process were observed only in the originally twinned region. The carbides were absent in the originally untwinned (twin-free) region. The experimental results have suggested that the formation of the carbides depends on the twinning-boundary ω-Fe metastable phase, which can be stabilised by interstitial carbon atoms. When the specimens were heated, the twinning-boundary ω-Fe(C) transformed into carbide (mainly θ-Fe3C cementite) particles on the original {112} twinning planes. Further heating resulted in substantial recrystallisation of α-Fe fine particles, which formed immediately after martensite transformation. The results presented here should be helpful in understanding the microstructural evolution of various carbon steels.
Sociomarkers and biomarkers: predictive modeling in identifying pediatric asthma patients at risk of hospital revisits
Authors: Shin Eun Kyong , Mahajan Ruhi , Akbilgic Oguz , Shaban-Nejad Arash
Published: September 2018

The importance of social components of health has been emphasized both in epidemiology and public health. This paper highlights the significant impact of social components on health outcomes in a novel way. Introducing the concept of sociomarkers, which are measurable indicators of social conditions in which a patient is embedded, we employed a machine learning approach that uses both biomarkers and sociomarkers to identify asthma patients at risk of a hospital revisit after an initial visit with an accuracy of 66%. The analysis has been performed over an integrated dataset consisting of individual-level patient information such as gender, race, insurance type, and age, along with ZIP code-level sociomarkers such as poverty level, blight prevalence, and housing quality. Using this uniquely integrated database, we then compare the traditional biomarker-based risk model and the sociomarker-based risk model. A biomarker-based predictive model yields an accuracy of 65% and the sociomarker-based model predicts with an accuracy of 61%. Without knowing specific symptom-related features, the sociomarker-based model can correctly predict two out of three patients at risk. We systematically show that sociomarkers play an important role in predicting health outcomes at the individual level in pediatric asthma cases. Additionally, by merging multiple data sources with detailed neighborhood-level data, we directly measure the importance of residential conditions for predicting individual health outcomes.
Current State-of-the-art Membrane Based Filtration and Separation Technologies
Authors: Su Yang
Published: September 2018

Membrane based filtration and separation technologies offer energy-efficient solutions for a wide range of applications, from clean water technology to chemical manufacturing, the petroleum industry and carbon emission control. With the current global energy and water challenges and the emergence of nanomaterials, membrane based separation is attracting ever-increasing interests from both academic societies and industries. Recent innovations in membrane materials have provided great enhancements for separation performance, which has led to the next-generation membrane based separation technologies. In this chapter, the development of a wide variety of separation technologies has been reviewed with the emphasis on membrane materials. Nanofiltration and desalination have been highlighted with the recent advances in nanomaterials-enabled, in particular graphene based, advanced membranes.
Selective Mass Transport Properties of Graphene Oxide Lamellar Membranes
Authors: Sun Pengzhan , Zhu Hongwei
Published: September 2018

Graphene oxide (GO) features a unique structure of sp2 hybridized carbon clusters and rich oxygen-containing functional groups co-existing within a two-dimensional (2D) lattice. Due to energetic favorability, the oxygen functional groups tend to cluster together, leaving the empty sp2 aromatic nanoclusters to form an interconnected percolation pathway. Upon stacking numerous GO nanosheets together to form a macroscopic lamellar membrane, the oxygen functional groups attached on GO basal planes act as pillars to support the unoxidized sp2 percolation pathway on individual layers to form a nanocapillary network by connecting with each other across the whole lamellar structure, which is presumably responsible for transmembrane mass transport. In recent years, the research on mass transport properties of GO-based membranes has received intense interest and significant advancements have been achieved both experimentally and theoretically. In this chapter, we review the recent developments in this burgeoning research field by emphasizing the transport properties of water, dissolved ions and molecules, and gaseous atoms and molecules through GO membranes. Finally, a perspective has been given for future developments.
Simple construction of ratiometric fluorescent probe for the detection of dopamine and tyrosinase by the naked eye
Authors: Mao Guobin , Du Mingyuan , Wang Xinxin , Ji Xinghu , He Zhike
Published: September 2018

A simple and effective method for constructing a ratiometric fluorescent probe for the detection of dopamine and tyrosinase was developed.
Activating 2D nano-kaolinite using hybrid nanoparticles for enhanced phosphate capture
Authors: Wei Yanfu , Yuan Peng , Song Yaran , Liu Dong , Losic Dusan , Tan Daoyong , Chen Fanrong , Liu Hongchang , Du Peixin , Zhou Junming
Published: September 2018

A natural 2D kaolinite host is activated by hybridizing with adsorptive La-based nanoparticles, demonstrating efficient phosphate capture.
Luminescence polarization of gold nanoclusters reveals directional self-assembly
Authors: Kuppan Balamurugan
Published: September 2018

One-dimensional cross-linked self-assembly driving the luminescence polarization of Au nanoclusters.
Impact-induced gelation in aqueous methylcellulose solutions
Authors: Parvari Galit , Rotbaum Yonatan , Eichen Yoav , Rittel Daniel
Published: September 2018

Inverse-freezing materials were known to solidify when heated – now a new stimulus is shown to induce this transition within microseconds’ timescales: mechanical impacts.
DNA-Mediated rolling circle amplification for ultrasensitive detection of thrombin using MALDI-TOF mass spectrometry
Authors: Wu Zengnan , Lin Ling , Khan Mashooq , Zhang Weifei , Mao Sifeng , Zheng Yajing , Li Zenghe , Lin Jin-Ming
Published: September 2018

A DNA-mediated rolling circle amplification (RCA) strategy was established for ultrasensitive and specific detection of thrombin via MALDI-TOF MS.
Tunable band gap of graphyne-based homo- and hetero-structures by stacking sequences, strain and electric field
Authors: Yun Jiangni , Zhang Yanni , Ren Yanbing , Xu Manzhang , Yan Junfeng , Zhao Wu , Zhang Zhiyong
Published: September 2018

Stacking sequences, external strain and a vertical electric field can be used to effectively modulate the electronic structures of graphyne-based homo- and hetero-structures.
Study of volume and surface plasmons in small silicon–hydrogen nanoclusters using the GW method
Authors: Matsko N. L.
Published: September 2018

Numerical calculations of surface and volume plasma excitations in silicon–hydrogen nanoclusters in the range Si10–Si60 and Si3H8–Si64H56 (size range 4–13.5 Å) are performed within the GW approximation.
Development of a biomimetic liver tumor-on-a-chip model based on decellularized liver matrix for toxicity testing
Authors: Lu Siming , Cuzzucoli Fabio , Jiang Jing , Liang Li-Guo , Wang Yimin , Kong Mengqi , Zhao Xin , Cui Wenguo , Li Jun , Wang ShuQi
Published: September 2018

A tumor-on-a-chip platform with integration of decellularized liver matrix offers better biomimicry of tumor microenvironment and enhanced toxicity testing.
Synthesis of a hydroxyapatite/poly(methyl methacrylate) nanocomposite using dolomite
Authors: Wijesinghe W. P. S. L. , Mantilaka M. M. M. G. P. G. , Karunarathne T. S. E. F. , Rajapakse R. M. G.
Published: September 2018

Hydroxyapatite/poly(methyl methacrylate) (HA–PMMA) nanocomposites are extensively used in biomedical fields.
New iridium-containing conjugated polymers for polymer solar cell applications
Authors: Keshtov M. L. , Kuklin S. A. , Konstantinov I. O. , Chen Fang-Chung , Xie Zhi-yuan , Sharma Ganesh D.
Published: September 2018

The highest value of power conversion efficiency is 1.74% for the P3 based polymer.
Facile synthesis of hierarchical porous solid catalysts with acid–base bifunctional active sites for the conversion of cellulose to 5-hydroxymethylfurfural
Authors: Wang Kai , Zhang Yunlei , Zhao Jiaojiao , Yan Changhao , Wei Yanan , Meng Minjia , Dai Xiaohui , Li Chunxiang , Yan Yongsheng
Published: September 2018

Hierarchical porous catalysts with acid–base bifunctional active sites were successfully synthesized using a Pickering HIPE template that was stabilized by halloysite nanotubes.
Roll-to-roll redox-welding and embedding for silver nanowire network electrodes
Authors: Kim Yeontae , Sul Yeong Eun , Kang Hyungseok , Choi Yongsuk , Lim Ho Sun , Lee Sungjoo , Pu Lyongsun , Yi Gi-Ra , Cho Sung Min , Cho Jeong Ho
Published: September 2018

We developed a continuous roll-to-roll redox-welding and embedding method for the fabrication of electrodes of silver nanowire (AgNWs) networks.
The formation of a functional pentacene/CH3NH3PbI3−xClx perovskite interface: optical gating and field-induced charge retention
Authors: Kim Youngjun , Kim Juyun , Ko Hyungduk , Park Byoungnam
Published: September 2018

We fabricated a functional pentacene/CH3NH3PbI3−xClx perovskite interface where optical gating and field assisted charge retention occur.
Enhanced luminescence and energy transfer in Mn2+ doped CsPbCl3−xBrx perovskite nanocrystals
Authors: Fei Liling , Yuan Xi , Hua Jie , Ikezawa Michio , Zeng Ruosheng , Li Haibo , Masumoto Yasuaki , Zhao Jialong
Published: September 2018

The enhanced luminescence of Mn2+ in Mn2+:CsPbCl3−xBrx NCs is related to Br composition-dependent energy transfer from excitons to Mn2+.
Determination of 8-hydroxy-2′-deoxyguanosine oxidative stress biomarker using dysprosium oxide nanoparticles@reduced graphene oxide
Authors: Manavalan Shaktivel , Rajaji Umamaheswari , Chen Shen-Ming , Steplin Paul Selvin S. , Govindasamy Mani , Chen Tse-Wei , Ajmal Ali M. , Al-Hemaid Fahad M. A. , Elshikh M. S.
Published: September 2018

Electrochemical detection of 8-OHdG biomarker using Dy2O3@RGO/SPCE.
Effects of different types of unsymmetrical squaraines on the material properties and Coulomb interactions in organic photovoltaic devices
Authors: Yang Lin , Yang Daobin , Chen Yao , Wu Jianglin , Lu Zhiyun , Sasabe Hisahiro , Kido Junji , Sano Takeshi , Huang Yan
Published: September 2018

A device architecture investigation with varying spacer thickness confirmed that Coulomb interactions exist between the donor phase and electrons in the PC71BM phase.
Naphthoquinones of the spinochrome class: occurrence, isolation, biosynthesis and biomedical applications
Authors: Hou Yakun , Vasileva Elena A. , Carne Alan , McConnell Michelle , El-Din A. Bekhit Alaa , Mishchenko Natalia P.
Published: September 2018

This review examines the structures of spinochromes and their isolation techniques, and evaluates their identification, biosynthesis and chemical synthesis.
Tailoring of the chlorine sensing properties of substituted metal phthalocyanines non-covalently anchored on single-walled carbon nanotubes
Authors: Sharma Anshul Kumar , Mahajan Aman , Kumar Subodh , Debnath A. K. , Aswal D. K.
Published: September 2018

Schematic view of the interaction between Cl2 and S1/S2 hybrid sensor.
Unlocked nucleic acid modified primer-based enzymatic polymerization assay: towards allele-specific genotype detection of human platelet antigens
Authors: Le Bao T. , Hughes Quintin , Rakesh Shilpa , Baker Ross , Jørgensen Per T. , Wengel Jesper , Veedu Rakesh N.
Published: September 2018

We investigated the potential of UNA-modified primers for mismatch recognition capabilities using enzymatic polymerisation approach. Efficient allele-specific discrimination was achieved with the UNA-modified primers unlike the DNA primers.
KI-catalyzed oxidative cyclization of α-keto acids and 2-hydrazinopyridines: efficient one-pot synthesis of 1,2,4-triazolo[4,3-a]pyridines
Authors: Yang De-Suo , Wang Juan , Gao Peng , Bai Zi-Jing , Duan Dong-Zhu , Fan Ming-Jin
Published: September 2018

A one-pot approach to 1,2,4-triazolo[4,3-a]pyridines via KI-catalyzed oxidative cyclization was developed with good economical and environmental advantages.
Calixarene alpha-ketoacetylenes: versatile platforms for reaction with hydrazine nucleophile
Authors: Muravev Anton A. , Solovieva Svetlana E. , Galieva Farida B. , Bazanova Olga B. , Rizvanov Ildar Kh. , Ivshin Kamil A. , Kataeva Olga N. , Matthews Susan E. , Antipin Igor S.
Published: September 2018

Late stage diversification of calix[4]arenes and thiacalix[4]arenes with heterocycles remains a significant synthetic challenge and hampers further exploitation of the scaffolds.
A sensitive electrochemical sensor based on ZIF-8–acetylene black–chitosan nanocomposites for rutin detection
Authors: Jin Ya-feng , Ge Chuang-ye , Li Xiao-bo , Zhang Miao , Xu Guang-ri , Li Dong-hao
Published: September 2018

A sensitive ZIF-8-AB-CS/GCE for rutin detection is constructed and the interaction between them is discussed for the first time.
Ethylenediamine mediated luminescence enhancement of pollutant derivatized carbon quantum dots for intracellular trinitrotoluene detection: soot to shine
Authors: Devi S. , Gupta Raju K. , Paul A. K. , Kumar Vinay , Sachdev Abhay , Gopinath P. , Tyagi S.
Published: September 2018

Vehicle-generated toxic pollutants are composed of gaseous smoke and particulate byproducts accumulated as a black substance at its exhaust.
Synthesis, supramolecular organization and thermotropic phase behaviour of N-acyltris(hydroxymethyl)aminomethane
Authors: Megarajan Sengan , Subramaniyan Siva Bala , Muthuswamy Sureshan , Anthony Savarimuthu Philip , Arunachalam Jothi , Moon Dohyun , Veerappan Anbazhagan
Published: September 2018

Self assembly of N-acyltris(hydroxymethyl)aminomethane into interdigitized vesicles.
In situ reactive coating of metallic and selenophilic Ag2Se on Se/C cathode materials for high performance Li–Se batteries
Authors: Sun Fugen , Li Yahui , Wu Zilong , Liu Yu , Tang Hao , Li Xiaomin , Yue Zhihao , Zhou Lang
Published: September 2018

A facile methodology has been developed to in situ coat metallic and selenophilic Ag2Se on Se/mesoporous carbons for high-performance Li–Se batteries.
Theoretical studies on the structural and spectral properties of two specific C54 isomers and the chlorinated species C54Cl8
Authors: Song Xitong , Li Xiaoqi , Qi Jiayuan
Published: September 2018

Chloride derivatives of fullerenes containing TSFP, TDFP and DFP carbon sites were characterized by spectral simulation.
Copper-mediated 1,2-bis(trifluoromethylation) of arynes
Authors: Yang Xinkan , Tsui Gavin Chit
Published: September 2018

A novel 1,2-bis(trifluoromethylation) of arynes using [CuCF3] is described.
High-performance mixed-dimensional perovskite solar cells with enhanced stability against humidity, heat and UV light
Authors: Zheng Haiying , Liu Guozhen , Chen Xiaojing , Zhang Bing , Alsaedi Ahmed , Hayat Tasawar , Pan Xu , Dai Songyuan
Published: September 2018

By introducing HOCH2CH2NH3I, new MD perovskite solar cells with a high PCE of 18.79% and improved humidity, heat and UV light stability are obtained.
Sifting α,ω-di(thiophen-2-yl)alkanes as solvent additives to boost the photovoltaic performance of the PTB7-Th:PC71BM blend
Authors: Gao Jianhong , Wang Wei , Zhan Chun , Hu Yanqi , Xiao Shengqiang , Lu Xinhui , You Wei
Published: September 2018

Using α,ω-di(thiophen-2-yl)alkanes as solvent additives instead of DIO to process PTB7-Th:PC71BM PSCs leads to improved device performance and stability.
Electroreduction of a CoIIcoordination complex producing a metal–organic film with high performance toward electrocatalytic hydrogen evolution
Authors: Bezerra Leticia S. , Rosa Persiely P. , Fortunato Guilherme V. , Pizzuti Lucas , Casagrande Gleison A. , Maia Gilberto
Published: September 2018

Remarkable, high stability, simple, and inexpensive noble metal-free materials as electrocatalysts with the best TOF (312 900 s−1, corrected by Faraday efficiency) for H2production.
A study of polyethylene glycol backfilling for enhancing target recognition using QCM-D and DPI
Authors: Du Yanqiu , Jin Jing , Jiang Wei
Published: September 2018

Long PEGs were used to bind biomolecules and short PEGs were used to backfill and suppress nonspecific protein adsorption.
Ultrasensitive diffraction gratings based on smart hydrogels for highly selective and rapid detection of trace heavy metal ions
Authors: Peng Han-Yu , Wang Wei , Gao Fuhua , Lin Shuo , Liu Lu-Yue , Pu Xing-Qun , Liu Zhuang , Ju Xiao-Jie , Xie Rui , Chu Liang-Yin
Published: September 2018

A smart-hydrogel-based ultrasensitive grating system with ultra-low detection limit for highly-selective and rapid detection of trace heavy metal ions is developed.
Liquid metal nano/micro-channels as thermal interface materials for efficient energy saving
Authors: Zhao Liuying , Liu Huiqiang , Chen Xuechen , Chu Sheng , Liu Han , Lin Zuoye , Li Qiuguo , Chu Guang , Zhang Hang
Published: September 2018

Thermal interface material (TIMs) pads/sheets with both high elasticity and low thermal resistance are indispensable components for thermal management.
Structural and functional characterisation of the entry point to pyocyanin biosynthesis in Pseudomonas aeruginosa defines a new 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase subclass
Authors: Sterritt Oliver W. , Lang Eric J.M. , Kessans Sarah A. , Ryan Timothy M. , Demeler Borries , Jameson Geoffrey B. , Parker Emily J.
Published: September 2018

In Pseudomonas aeruginosa (Pae), the shikimate pathway end product, chorismate, serves as the last common precursor for the biosynthesis of both primary aromatic metabolites, including phenylalanine, tyrosine and tryptophan, and secondary aromatic metabolites, including phenazine-1-carboxylic acid (PCA) and pyocyanin (PYO). The enzyme 3-deoxy-d-arabino-heptulosonate 7-phosphate synthase (DAH7PS) catalyses the first committed step of the shikimate pathway, en route to chorismate. P. aeruginosa expresses multiple, distinct DAH7PSs that are associated with either primary or secondary aromatic compound biosynthesis. Here we report the structure of a type II DAH7PS, encoded by phzC as part of the duplicated phenazine biosynthetic cluster, from P. aeruginosa (PAO1) revealing for the first time the structure of a type II DAH7PS involved in secondary metabolism. The omission of the structural elements α2a and α2b, relative to other characterised type II DAH7PSs, leads to the formation of an alternative, dimeric, solution-state structure for this type II DAH7PS with an oligomeric interface that has not previously been characterised and that does not facilitate the formation of aromatic amino acid allosteric binding sites. The sequence similarity and, in particular, the common N-terminal extension suggest a common origin for the type II DAH7PSs from P. aeruginosa. The results described in the present study support an expanded classification of the type II DAH7PSs as type IIA and type IIB based on sequence characteristics, structure and function of the resultant proteins, and on defined physiological roles within primary or secondary metabolism.
Extracellular vesicles: translational challenges and opportunities
Authors: Clemmens Hannah , Lambert Daniel W.
Published: September 2018

Extracellular vesicles (EVs) are a heterogeneous group of small lipid-enclosed structures with myriad roles in physiology and disease. The recent surge of interest in EVs has led to greater understanding of their biology and appreciation of how they might be utilised as diagnostic and therapeutic tools. There remain, however, a number of challenges that must be overcome before EVs may be used routinely in the clinic. In this review we will discuss the translational potential of EVs and the current technologies available to isolate, purify and analyse EVs and their contents.
The Golgi architecture and cell sensing
Authors: Makhoul Christian , Gosavi Prajakta , Gleeson Paul A.
Published: September 2018

An array of signalling molecules are located at the Golgi apparatus, including phosphoinositides, small GTPases, kinases, and phosphatases, which are linked to multiple signalling pathways. Initially considered to be associated predominantly with membrane trafficking, signalling pathways at the Golgi are now recognised to regulate a diverse range of higher-order functions. Many of these signalling pathways are influenced by the architecture of the Golgi. In vertebrate cells, the Golgi consists of individual stacks fused together into a compact ribbon structure and the function of this ribbon structure has been enigmatic. Notably, recent advances have identified a role for the Golgi ribbon in regulation of cellular processes. Fragmentation of the Golgi ribbon results in modulation of many signalling pathways. Various diseases and disorders, including cancer and neurodegeneration, are associated with the loss of the Golgi ribbon and the appearance of a dispersed fragmented Golgi. Here, we review the emerging theme of the Golgi as a cell sensor and highlight the relationship between the morphological status of the Golgi in vertebrate cells and the modulation of signalling networks.
Mitochondrial calcium signalling and neurodegenerative diseases
Authors: Britti Elena , Delaspre Fabien , Tamarit Jordi , Ros Joaquim
Published: September 2018

Calcium is utilised by cells in signalling and in regulating ATP production; it also contributes to cell survival and, when concentrations are unbalanced, triggers pathways for cell death. Mitochondria contribute to calcium buffering, meaning that mitochondrial calcium uptake and release is intimately related to cytosolic calcium concentrations. This review focuses on the proteins contributing to mitochondrial calcium homoeostasis, the roles of the mitochondrial permeability transition pore (MPTP) and mitochondrial calcium-activated proteins, and their relevance in neurodegenerative pathologies. It also covers alterations to calcium homoeostasis in Friedreich ataxia (FA).
Equilibrium strategies for time-inconsistent stochastic switching systems
Authors: Mei Hongwei , Yong Jiongmin
Published: September 2018

An optimal control problem is considered for a stochastic differential equation containing a state-dependent regime switching, with a recursive cost functional. Due to the non-exponential discounting in the cost functional, the problem is time-inconsistent in general. Therefore, instead of finding a global optimal control (which is not possible), we look for a time-consistent (approximately) locally optimal equilibrium strategy. Such a strategy can be represented through the solution to a system of partial differential equations, called an equilibrium Hamilton–Jacob–Bellman (HJB) equation which is constructed via a sequence of multi-person differential games. A verification theorem is proved and, under proper conditions, the well-posedness of the equilibrium HJB equation is established as well.
Artificial neural network inspired by quantum computing solutions using the movement model of the PR-02 robot
Authors: Tchórzewski Jerzy , Ruciński Dariusz , Domański Przemysław
Published: September 2018

The paper proposes a new method of quantum computing using control and systems theory as well as matrix-quantum computing. The algorithm developed on the basis of the PR-02 robot’s arm’s movement was implemented in using the Neural Network Toolbox. The application of the neural model instead of the analytic model allowed for obtaining the improvement of the trajectory of the PR-02 robot’s arm movement, while the application of the quantum artificial neural network for the assumed number of quasi-parallel computations equal 1000 did not result in the improvement of the model.
Field – Circuit Model of Wireless Transmission Power System using Ω–T–T0 Formulation
Authors: Kurzawa Milena , Wojciechowski Rafał M.
Published: September 2018

The paper discusses the field-circuit model of the wireless power transmission system (WPTS) with the air-core high-frequency transformer. While working on the field model, a formulation which uses scalar magnetic potential Ω and electric vector potentials T and T0 was implemented. Model equations were provided. The system which consists of magnetically coupled coils connected with the elements of external circuits was taken into consideration. The selected results of simulation calculations were presented. The obtained results of simulation calculations were compared with the results of measurements obtained at a laboratory post.
Adaptive functions in G0> and YY0 earth fault protection
Authors: Lorenc Józef , Łowczowski Krzysztof , Staszak Bogdan
Published: September 2018

In this paper, the benefits resulting from the application of YY0 and G0> earth fault protection with adaptive functions − limiting the risk of outsiders being shocked and reducing the likelihood of two-phase short-circuiting with the ground, are presented. The possibilities of improving the effectiveness of admittance protection by introducing special adaptive functions in control algorithms of station automation and decision algorithms of YY0 and G0> criteria are shown. The rules for using such functions have been described and it has been shown that they have a very significant impact on improvement the effectiveness of protection system. It can be stated that in typical medium voltage networks and solutions of active adaptive functions, good conditions are obtained for the operation of admittance protections even at several times higher resistances in the place of earth fault than when these functions are deactivated or not implemented.
Analysis of power system operation at asymmetrical load
Authors: Paszek Stefan , Nocoń Adrian , Pruski Piotr
Published: September 2018

The paper presents a mathematical model of a power system (PS) consisting of a generating unit (with a synchronous generator) connected by a high voltage (transmission) power line to a bus. The state and output equations of the generator are expressed in the coordinate system d, q, 0 and with the use of phase quantities of the generator stator, the bus and the power line, which is especially useful in the analysis of asymmetrical states. A disturbance of the steady state in the form of a two-phase short-circuit in the transmission line was taken into account in the made calculations. The influence of the excitation system and angular speed control system of the generator as well as the impact of selected generator model parameters on the waveforms were investigated.
Analysis of vibration energy harvester with magnetic spring
Authors: Kulik Marcin , Gabor Rafał , Jagieła Mariusz
Published: September 2018

In paper an electromagnetic energy harvester with two fixed permanent magnets and one moving suspended vertically by the magnetic interaction between them. The external force imposed on the system causes displacement of the magnet whose magnetic field induces emf in the coil wound around it. In order to obtain the resonance frequency around 25 Hz, the numerical optimisation was carried out. The measured frequency characteristics of the manufactured system compare well with results of computer simulation.
Applying the princigples of stage lighting in the illumination of the monument Państwa Podziemnego i Armii Krajowej in Poznan
Authors: Mroczkowska Sandra , Górczewska Małgorzata , Wandachowicz Krzysztof
Published: September 2018

Designing the illumination of monuments requires an analysis of a number of determinants of their meaning and symbolism and the emotion which lighting should express. When choosing lighting solutions, the rules used in stage lighting may be helpful. Computer visualization of effects in different ways of illuminating an object facilitates the evaluation and choice of final lighting solutions.
Tribological advancement – strategies and effects towards emissions and global energy consumption
Authors: Hassan Masjuki , Amzar Zulkifli Syahir , Hasnul Harith , Yusoff Ashraf
Published: September 2018

This paper investigates the importance of tribology towards the global economy. The current world energy crisis, the depletion of fossil fuel reserves and the increasing of environmental hazards over the years have urged academicians and scientists to continuously seek for methods to overcome these problems while improving the quality of life in the same time. Energy saving can be achieved through the implementation of tribological improvements in various sectors such as transportation, manufacturing, power generation and residential sectors. The friction reductions eventually lead to wear reduction, energy loss reduction and CO2 emission reduction due to the lesser energy consumption. Therefore, it can be concluded that advanced tribological technologies benefits the entire world in the economical aspect through energy saving and emission reductions.
Multistage artificial aging optimization for tensile properties of Duralium using Response Surface Method (RSM)
Authors: Puspitasari Poppy , Dewi Izzatus Tsamroh , Achyarsyah Mochamad , Bandanajaya Beny , puspitasari Dewi
Published: September 2018

This study developing mathematical model to optimize heat treatment process to obtain the most significant parameter that affected tensile strength of duralium through multistage artificial aging. The process parameters in this study were temperature of aging, holding time of aging, and artificial aging process was conducted in double stages. The experiments were conducted according to central composite design matrix. The adequacy of developed model was analysed by analysis of variance (ANOVA). The optimum parameter of multistage artificial aging was obtained for maximum tensile strength of duralium.
A heuristic method for solving airline crew pairing problems
Authors: Novianingsih Khusnul , Hadianti Rieske
Published: September 2018

The airline crew pairing problem is one of the optimization problems which classified as a NP-hard problem. Since the number of feasible pairings in flight schedules can be numerous, the exact methods will not efficient to solve the problem. We propose a heuristic method for solving crew pairing problems. Initially, we generate a feasible solution by maximizing the covered flights. Then, we improve the solution by constructing a procedure to avoid the local optimal solution. We test our method to an airline schedules. The computational results show that our method can give the optimal solution in short period of time.
Microwave-assisted extraction of phenolic compounds from Moringa oleifera seed as anti-biofouling agents in membrane processes
Authors: Izza Ni'matul , Dewi Shinta Rosalia , Setyanda Ashried , Sukoyo Agung , Utoro Panggulu , Al Riza Dimas Firmanda , Wibisono Yusuf
Published: September 2018

Moringa seed has known as a coagulant in the water purification process. It is because of the large amount of anti-microbial compounds contained in it. Phenol is one of the most common anti-microbial compounds found in natural materials. The aim of this study was to determine the total phenolic content (TPC) of Moringa seed which was extracted by Microwave-Assisted Extraction (MAE). Moringa seeds were characterized by FTIR and showed that it contained phenol compounds confirmed by specific peak in some areas. Moringa seeds were characterized by FTIR before extracted. Therefore, MAE was performed by variation of solvent ratios (1: 4, 1: 6, 1: 8) and extraction time (2, 3, 4 min). The highest TPC of 41.78 mg GAE / g dw was reached at 1: 8 solvent ratio and 3-min extraction time.
Fire risk assessment on hammer mill machine with human reliability assessment (HRA) and component reliability approaches
Authors: Amalia Khariza , Amrullah Haidar Natsir , Subekti Arief , Ashari Moch. Luqman , Hidayat Edy Prasetyo , Mudjiono Urip , Widodo Hendro Agus
Published: September 2018

In the animal feed industry, hammer mill machinery plays an important role in the smashing of raw materials. By 2017, in an animal feed industry there has been a fire on the dust collector that almost burned down the hammer mill machine. In previous years also often occur sparks arising due to the knife rubbing against the metal that carried away with raw material. However, the fire will not increase if the hammer mill machine operators are competent in extinguishing the fire. The purpose of this study is to find out how much the effects of hammer mill machine fire fighting in terms of safety scenarios that exist either from human procedures or automatic safety procedures performed by existing safety devices. In this study, using a combination of calculations between Human Error Probability (HEP) values obtained from Human Reliability Assessment (HRA) calculations using SPAR-H method and reliability calculation of hammer mill machine components obtained from downtime data for four years, 2014 until 2017. The total probability of outcome fire controlled increases from 0.177940 to 0,6393 and the total probability of outcome fire uncontrolled decreases from 0,82206 to 0,36068.
Enhanced rooftop rainwater harvesting quality through filtration using zeolite and activated carbon
Authors: Yulistyorini Anie , Idfi Gilang , Fahmi Evy Dwi
Published: September 2018

This study aimed to investigate the quality of the rooftop rainwater harvesting (RRWH) and to treat it for clean water supply alternative of Graha Rektorat building at State University of Malang, Indonesia. Different combinations of zeolite and activated carbon were used as filter media to treat the RRWH. Several parameters have tested to investigate the quality of RRWH based on Permenkes RI No. 416 / MENKES / PER / IX / 1990. Most of the quality of the RRWH met clean water and drinking water standard. However, there were three parameters have to be reduced and required further treatment. The results showed T4 reduced TDS and coliform bacteria by 37% and 36%, while T5 eliminated organic substances (KMnO4) for 35%.
Spark ignition engine modeling for in-cylinder pressure and temperature prediction using simulink
Authors: Septivani Nike , Riyandwita Byan Wahyu
Published: September 2018

Mathematical model for four-stroke gasoline engines based on a cylinder-by-cylinder engine modeling method that incorporates physical formulas such as engine geometry and empirical formulas such as combustion duration are applied in this study. In-cylinder pressure and temperature can be calculated for gasoline four-cycle engine. Modeling is done by treating each step in the cylinder as a volume control, solving the conservation equations of energy with submodules for combustion, heat transfer and dynamic analysis. Calculations in cycles are performed at each crank angle, so that the correct angle of ignition, variations in velocity, amount of intake mass and fuel burning speed can be predicted. Adjustment for the combustion parameter such as burn duration and form factor of the Wiebe function to increase the model accuracy was performed. It is shown that the optimization of the Wiebe function parameters able to improve the sum squared error of the engine pressure estimation by 58.17% compared to the result from generalized parameter functions, and the parameter of form factor and burn duration are influential by around twice of (1.86 and 2.55 times, respectively) the efficiency factor.
Mitigation of the alternative energy for the wind farm center considering temperature and wind speed
Authors: Prastika Rima Septiani , Afandi A.N. , Prihanto Dwi
Published: September 2018

Recently, electric usages are increasing every year by year in many sectors. In facts, fossil fuels have been fueled to produce electrical energy availability at many power plants which are very limited for the sustainable procurement. Developing and implementing renewable energy sources should be urgently promoted to reduce the dependence on fossil fuels that have been fueled to generate electricity for the long period throughout various power plant combinations. In expectation, the natural source of electrical energy which environmentally friendly and easy to obtain in nature is recommended to explore for the existing energy producers. The natural source of energy can be operated as an alternative power plant to reduce environmental effects and to decrease air contaminants. These works cover those opportunities. In these studies, the method used is a quantitative category with collected primary and secondary data for all evaluations and mitigations. In general, these works are also designed for identifying problems and looking for literature, data collection, processing stage, analysis phase, and final conclusion. The data used is defined in terms of temperature, air pressure, and wind speed. The collected data are supposed to the Purwoharjo City of Banyuwangi Regency, with 10 meters above ground level. Naturally, the wind speed is about 3.5 m/s to 4 m/s and the average temperature is 300° Kelvin. The potentially generated wind energy at a single point of coordinates is around 85.17 Wh.
Modelling Integration of System Dinamics and Game Theory for of Financial Technology Peer to Peer Lending Industry
Authors: Anresnani Deririnda Setyo , Widodo Erwin , Syairuddin Bambang
Published: September 2018

In Indonesia, internet users from 2013 to 2018 have increased about 52%. This growth indicates that people behaviour change in many aspects of life including in economy. One example is (Fintech P2P Lending). P2P lending is a service that offers online borrowing, lenders can loan to small business or individuals. This is in line with the Indonesia Financial Services Sector Master Plan 2015-2019. Indonesia support the rapid growth of the financial technology ecosystem, but there is need good understanding between related parties such as P2P Lending companies, lenders and borrowers. A system dynamics act as calculators to takes value to fill payoff table in game theory. Integration of system dynamics and game theory can produce the best strategy for Fintech P2P Lending in running its business while considering profit for lenders and borrowers. The best strategy is known by use non-cooperative and cooperative game theory. The result shown the best strategy for each player with non-cooperative game is when the company chooses a high level of profit margin, borrower chooses low level of debt time, and lender chooses high level of ROI. In cooperative game, the best strategy is when the company chooses a high level of profit margin, borrower chooses low level of debt time, and lender chooses low level of ROI.
Simulation of human bone implant duralium material with variation loading using Ansys software
Authors: Mujahidin Didin , Puspitasari Poppy , Kustono Djoko
Published: September 2018

Bone implants are a tool used as a support of body parts, and bone support in cases of fractures. Scaffold, plate, bone screw, and some other tools can be used in combination to support and fill the connection between broken bones before the tissue grows. The most commonly used implant materials are Titanium, Stainless steel and ceramics, which are very common in the use of medical devices. Biocompatible materials are taken into consideration when planning a medical device. This research intended to know the durability of duralumin material as the latest implant material, as the development and breakthrough in health world. The research methodology used in this study was the optimization in Ansys software 18.1. The implants were designed, the material strength was determined and then given imposition with 6 variations (450 N, 550 N, 650 N, 750 N, 850 N and 950 N). The optimization was a method that identified mat erial strength including Equivalent Stress, Shear Stress and Total Deformation of duralumin material as implant materials with loading variations. Based on the results of the research, the duralumin material had a equivalent stress of 475,700 Pa which was higher than 950000 Pa for ZnO-Al2O3 implants, while the duralumin shear stress of 1084500 Pa was higher than 313720 Pa for ZnO-Al2O3 implants. When compared with titanium implants, the highest equivalent stress of 150000 Pa duralumin material had a higher compression stress than titanium. The highest shear stress of titanium 4358.1 Pa means an implant with a higher shear duralumin material of titanium. Whereas if it was compared to stainless steel with voltage press 564000000 Pa, then the duralumin’s pressure was getting lower. Material hardness affects resistance to wear and tear. Duralumin material hardness was lower than Titanium and ZnO-Al2O3, so total Duralumin deformation (elasticity) was higher than Titanium and ZnO-Al2O3.
Analysis and interpretation of inner-heliospheric SEP events with the ESA Standard Radiation Environment Monitor (SREM) onboard the INTEGRAL and Rosetta Missions
Authors: Georgoulis Manolis K. , Papaioannou Athanasios , Sandberg Ingmar , Anastasiadis Anastasios , Daglis Ioannis A. , Rodríguez-Gasén Rosa , Aran Angels , Sanahuja Blai , Nieminen Petteri
Published: September 2018

Using two heliospheric vantage points, we study 22 solar energetic particle (SEP) events, 14 of which were detected at both locations. SEP proton events were detected during the declining phase of solar cycle 23 (November 2003–December 2006) by means of two nearly identical Standard Radiation Environment Monitor (SREM) units in energies ranging between 12.6 MeV and 166.3 MeV. In this work we combine SREM data with diverse solar and interplanetary measurements, aiming to backtrace solar eruptions from their impact in geospace (i.e., from L1 Lagrangian point to Earth’s magnetosphere) to their parent eruptions at the Sun’s low atmosphere. Our SREM SEP data support and complement a consistent inner-heliospheric description of solar eruptions (solar flares and coronal mass ejections [CMEs]) and their magnetospheric impact. In addition, they provide useful information on the understanding of the origin, acceleration, and propagation of SEP events at multi-spacecraft settings. All SEP events in our sample originate from major eruptions consisting of major (>M-class) solar flares and fast (>1800 km/s, on average), overwhelmingly (>78%) halo, CMEs. All but one SEP event studied are unambiguously associated with shock-fronted CMEs, suggesting a CME-driven shock acceleration mechanism. Moreover, a significant correlation is found between the SEP event peak and the onset of the storm sudden commencement, that might help improve prediction of magnetospheric disturbances. In general, SEP events correlate better with interplanetary (i.e., in-situ; L1-based) than with solar eruption features. Our findings support (a) the routine use of cost-effective SREM units, or future improvements thereof, for the detection of SEP events and (b) their implementation in multi-spacecraft settings as a means to improve both the physical understanding of SEP events and their forecasting.
Arterial Stiffening with Ultrafast Ultrasound Imaging Gives New Insight into Arterial Phenotype of Vascular Ehlers-Danlos Mouse Models
Authors: Goudot Guillaume , Papadacci Clément , Dizier Blandine , Baudrie Véronique , Ferreira Irmine , Boisson-Vidal Catherine , Tanter Mickaël , Jeunemaître Xavier , Pernot Mathieu , Messas Emmanuel , Mirault Tristan
Published: September 2018

Objective Vascular Ehlers–Danlos syndrome (vEDS) is associated with arterial ruptures due to a mutant gene encoding collagen type III (Col-III). To better understand the role of Col-III, we aimed at evaluating aortic stiffness and dynamic stiffening in vEDS mouse models, with either a quantitative (col3KO mice) or a qualitative Col-III defect (col3KI mice).

Materials and Methods Abdominal aortic wall pulse wave velocities (PWV) in col3KO and col3KI mice were compared to their respective wild type (WT) littermates using a 15 MHz ultrafast ultrasonic transducer. A carotid catheter continuously monitored pressure changes due to phenylephrine injections. PWV1, generated at diastolic blood pressure (DBP), and PWV2, at systolic blood pressure (SBP) were recorded. Difference between PWV2 and PWV1 (Delta-PWV) normalized by the pulse pressure (PP), corresponding to the aortic stiffening over the cardiac cycle, were compared between mutant and WT mice, as well as the regression slope of PWV as a function of pressure.

Results Delta-PWV/PP was lower in col3KO (p = 0.033) and col3KI mice (p < 0.001) vs. WT-mice regardless of the pressure level. The slope of PWV1 with DBP increase showed a lower arterial stiffness in mutant mice vs. controls in both models. This difference was amplified when evaluating stiffness at systolic blood pressure levels with PWV2.

Conclusion In both vEDS mouse models, aortic stiffening was reduced, mainly driven by a lower stiffness at systolic blood pressure. Defective Col-III may be responsible for this, as it is utilized when pressure rises. These pre-clinical data could explain vascular fragility observed in vEDS patients.
Cluster Preface: Atropisomerism
Authors: Siegel Jay
Published: September 2018

Jay S. Siegel received his Ph.D. from Princeton (1985), was a Swiss Universities Fellow at ETH Zurich (1983-4), and NSF–CNRS postdoctoral fellow at the University of Louis Pasteur in Strasbourg (1985-6). He began as Assistant Professor of Chemistry (1986) at UCSD, was promoted to Associate Professor (1992) and Full Professor (1996). In 2003, he was appointed as Professor and co-director of the Organic chemistry institute of the University of Zurich (UZH) and Director of its laboratory for process chemistry research (LPF). He served as Dean of Studies and Head of the Research Council for the Faculty of Sciences at UZH. He moved to Tianjin University in 2013 as dean and joined the Schools of Pharmaceutical and Life Sciences into a new Health Science Platform. His research is in the area of Stereochemistry and Physical Organic Chemistry.