bluuebunny/crossref_metadata_2025 huggingface dataset:
NIR light-activatable dissolving microneedle system for melanoma ablation enabled by a combination of ROS-responsive chemotherapy and phototherapy
Authors: Liu Fan , Cheng Zeneng , Yi Hanxi
Published: February 2023

Background

As a consequence of the aggressive and recurrent nature of melanoma, repeated, multimodal treatments are often necessary to cure the disease. While microneedle (MN)-based transdermal drug delivery methods can allow drugs to avoid first-pass metabolism and overcome the stratum corneum barrier, the main challenges of these delivery methods entail the lack of controlled drug release/activation and effective imaging methods to guide the entire treatment process.

Methods

To enable a transdermal delivery method with controllable drug release/activation and effective imaging guidance, we designed a near-infrared (NIR) photoactivatable, dissolving MN system comprising dissolvable polyvinylpyrrolidone MNs arrays (MN-pB/I) containing liposomes that were co-loaded with the photosensitizer indocyanine green (ICG) and the reactive oxygen species (ROS)-activatable prodrug of doxorubicin (pB-DOX).

Results

After applying the MN patch to the tumor site, the liposomes concentrated in the needle tips were released into the tumor tissue and distributed evenly upon dissolution of the matrix to enable targeted delivery. Then, the ROS produced by ICG after exposure to NIR light performed photodynamic therapy and activated the pB-DOX for chemotherapy by cleaving the prodrug moiety and converting it to DOX. As a dye, ICG was also used to guide the treatment regimens and monitor the efficacy by fluorescence and photoacoustic imaging. The growth of the tumors in the MN-pB/I group were inhibited by 93.5%, while those were only partially inhibited in the control groups. Negligible treatment-induced side effects and cardiotoxicity were observed.

Conclusion

The MN-pB/I represents a multimodal, biocompatible theragnostic system with spatiotemporal control that was capable of ablating melanoma tumors after a single dose, providing a promising candidate for clinical melanoma therapy.

Graphical Abstract
Advances in photobiomodulation for cognitive improvement by near-infrared derived multiple strategies
Authors: Pan Wei-tong , Liu Pan-miao , Ma Daqing , Yang Jian-jun
Published: February 2023

Cognitive function is an important ability of the brain, but cognitive dysfunction can easily develop once the brain is injured in various neuropathological conditions or diseases. Photobiomodulation therapy is a type of noninvasive physical therapy that is gradually emerging in the field of neuroscience. Transcranial photobiomodulation has been commonly used to regulate neural activity in the superficial cortex. To stimulate deeper brain activity, advanced photobiomodulation techniques in conjunction with photosensitive nanoparticles have been developed. This review addresses the mechanisms of photobiomodulation on neurons and neural networks and discusses the advantages, disadvantages and potential applications of photobiomodulation alone or in combination with photosensitive nanoparticles. Photobiomodulation and its associated strategies may provide new breakthrough treatments for cognitive improvement.
Clinical outcomes and lung toxicities after lung SABR using dynamic conformal arc therapy: a single-institution cohort study
Authors: Mesny Emmanuel , Ayadi Myriam , Dupuis Pauline , Beldjoudi Guillaume , Tanguy Ronan , Martel-Lafay Isabelle
Published: February 2023

Background

Stereotactic ablative radiotherapy (SABR) is a validated treatment for early stage lung cancer and pulmonary metastases. It provides a high local control rate with low symptomatic toxicities. Recently, Dynamic Conformal Arc Therapy (DCAT), a delivery option that differs from conventional DCA, has been implemented in the Monaco Treatment Planning System for SABR. The aim of the study was to report clinical outcomes and toxicities for patients treated for lung SABR with this new technique.

Methods

We retrospectively identified adult patients treated for primary or secondary lung tumors with DCAT-SABR and reported their clinical, radiological, histological characteristics and dosimetric parameters. Total dose was delivered in 3 or 5 fractions for 95% of patients and prescribed on the 80% isodose line to the PTV periphery.

Results

145 patients met inclusion criteria for a total of 152 lesions with a median follow up of 12 months. Local control for the irradiated site was 96.7% at 1 year. Overall survival was 93.1% at 1 year. Mean prescription dose in BED10 was 110 Gy. 92% of patients had a prescribed dose superior to 100 Gy BED10. Mean PTV coverage was 95.1%. There were 66 cases of grade 1 radiation pneumonitis (RP) (43%) and only 7 cases of symptomatic grade 2 RP (4.6%).

Conclusion

Lung SABR for primary or metastatic lung tumors using dynamic conformal arc therapy provides efficient results of local control and low lung toxicities, similar to other SABR techniques. Advances in knowledge: SABR using DCAT is a safe technique to treat lung lesions, allowing intra-fraction motion limitation, potentially higher OARs protection and a shortened beam delivery.
The effect of a multi-faceted quality improvement program on paramedic intubation success in the critical care transport environment: a before-and-after study
Authors: von Vopelius-Feldt Johannes , Peddle Michael , Lockwood Joel , Mal Sameer , Sawadsky Bruce , Diamond Wayde , Williams Tara , Baumber Brad , Van Houwelingen Rob , Nolan Brodie
Published: February 2023

Introduction

Endotracheal intubation (ETI) is an infrequent but key component of prehospital and retrieval medicine. Common measures of quality of ETI are the first pass success rates (FPS) and ETI on the first attempt without occurrence of hypoxia or hypotension (DASH-1A). We present the results of a multi-faceted quality improvement program (QIP) on paramedic FPS and DASH-1A rates in a large regional critical care transport organization.

Methods

We conducted a retrospective database analysis, comparing FPS and DASH-1A rates before and after implementation of the QIP. We included all patients undergoing advanced airway management with a first strategy of ETI during the time period from January 2016 to December 2021.

Results

484 patients met the inclusion criteria during the study period. Overall, the first pass intubation success (FPS) rate was 72% (350/484). There was an increase in FPS from the pre-intervention period (60%, 86/144) to the post-intervention period (86%, 148/173), p < 0.001. DASH-1A success rates improved from 45% (55/122) during the pre-intervention period to 55% (84/153) but this difference did not meet pre-defined statistical significance (p = 0.1). On univariate analysis, factors associated with improved FPS rates were the use of video-laryngoscope (VL), neuromuscular blockage, and intubation inside a healthcare facility.

Conclusions

A multi-faceted advanced airway management QIP resulted in increased FPS intubation rates and a non-significant improvement in DASH-1A rates. A combination of modern equipment, targeted training, standardization and ongoing clinical governance is required to achieve and maintain safe intubation by paramedics in the prehospital and retrieval environment.
Associations between different tau-PET patterns and longitudinal atrophy in the Alzheimer’s disease continuum: biological and methodological perspectives from disease heterogeneity
Authors: Mohanty Rosaleena , Ferreira Daniel , Nordberg Agneta , Westman Eric ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: February 2023

Background

Subtypes and patterns are defined using tau-PET (tau pathology) and structural MRI (atrophy) in Alzheimer’s disease (AD). However, the relationship between tau pathology and atrophy across these subtypes/patterns remains unclear. Therefore, we investigated the biological association between baseline tau-PET patterns and longitudinal atrophy in the AD continuum; and the methodological characterization of heterogeneity as a continuous phenomenon over the conventional discrete subgrouping.

Methods

In 366 individuals (amyloid-beta-positive cognitively normal, prodromal AD, AD dementia; amyloid-beta-negative cognitively normal), we examined the association between tau-PET patterns and longitudinal MRI. We modeled tau-PET patterns as a (a) continuous phenomenon with key dimensions: typicality and severity; and (b) discrete phenomenon by categorization into patterns: typical, limbic predominant, cortical predominant and minimal tau. Tau-PET patterns and associated longitudinal atrophy were contextualized within the Amyloid/Tau/Neurodegeneration (A/T/N) biomarker scheme.

Results

Localization and longitudinal atrophy change vary differentially across different tau-PET patterns in the AD continuum. Atrophy, a downstream event, did not always follow a topography akin to the corresponding tau-PET pattern. Further, heterogeneity as a continuous phenomenon offered an alternative and useful characterization, sharing correspondence with the conventional subgrouping. Tau-PET patterns also show differential A/T/N profiles.

Conclusions

The site and rate of atrophy are different across the tau-PET patterns. Heterogeneity should be treated as a continuous, not discrete, phenomenon for greater sensitivity. Pattern-specific A/T/N profiles highlight differential multimodal interactions underlying heterogeneity. Therefore, tracking multimodal interactions among biomarkers longitudinally, modeling disease heterogeneity as a continuous phenomenon, and examining heterogeneity across the AD continuum could offer avenues for precision medicine.
Dynamics of pastoral conflicts in eastern Rift Valley of Ethiopia: Contested boundaries, state projects and small arms
Authors: Burka Boru Musa , Roro Ameyu Godesso , Regasa Dereje Tesema
Published: February 2023

This article examines the conflict dynamics among the pastoralists in the eastern Rift Valley in Ethiopia. It focuses on the Ituu–Karrayuu pastoralists’ conflict encounters with their neighbours, the Afar and Argobba. The article aims to provide a deeper understanding of the changing patterns of the relation of conflict and land use in the territories shared by these groups and how it is influenced by boundary-making within Ethiopia in the early 1990s. It draws on fieldwork conducted in the Fantallee district in the Oromiya region from March to June 2020. The source of data for this article relies on qualitative methodology and data collected through interviews, focus group discussion, observation and document analysis. The data obtained through recording and note-taking were categorised and organised into relevant themes and analysed thematically. The findings reveal that the current pastoralist conflicts in the study area have become more rather than less dynamic and intense. Unlike the recent works on conflicts across the country, we argue that most of the conflicts occurring among the pastoral communities of the eastern Rift Valley are not driven by the policy of ethnic federalism alone. Instead, our research shows the changing nature of pastoralist conflicts is a consequence of multi-layered causes/actors and evolving state policies—in short, a consequence of a wider political and economic context. The study suggests the need for placing the pastoral issues within the broader political and economic contexts to address the tensions across the rangeland economy.
ARPC1A correlates with poor prognosis in prostate cancer and is up-regulated by glutamine metabolism to promote tumor cell migration, invasion and cytoskeletal changes
Authors: Chen Ye-Hui , Chen Hang , Lin Ting-Ting , Zhu Jun-Ming , Chen Jia-Yin , Dong Ru-Nan , Chen Shao-Hao , Lin Fei , Ke Zhi-Bin , Huang Jin-Bei , Wei Yong , Zheng Qing-Shui , Xue Xue-Yi , Xu Ning
Published: February 2023

Objective

This study aimed to identify potential biomarkers for prostate cancer (PCa) progression and metastasis, and to discern their biological functions.

Methods

Bioinformatics methods were used to screen for hub genes. The expression level of key hub genes in PCa was determined and their prognostic significance was examined. A series of functional assays were performed to investigate the function of the highest-ranking hub gene.

Results

Actin related protein 2/3 complex subunit 1A (ARPC1A) was identified as the hub gene. ARPC1A was highly expressed in PCa tissues and cell lines, and was an independent prognostic factor for predicting biochemical recurrence after radical prostatectomy and overall survival of PCa patients. Knockdown of ARPC1A inhibited PCa cell migration, invasion and cytoskeleton formation, but had no impact on cell proliferation and cell cycle progression. In vivo, ARPC1A overexpression promoted lung metastasis of PCa, but had no efffect on tumor growth. Additionally, glutamine metabolism was identified as an upstream regulator of ARPC1A, and promoted migration, invasion and cytoskeletal changes of PCa cell through ARPC1A.

Conclusion

These findings suggested that ARPC1A, which correlates with poor prognosis in PCa, functions downstream of glutamine metabolism to regulate cytoskeletal changes, cellular migration and cellular invasion in this disease.
Structural Safety Inspection of Reinforced Concrete Structures Considering Failure Probabilities of Structural Members
Authors: Cho Hae-Chang , Lee Sang-Hoon , Choi Seung-Ho , Yi Seong-Tae , Kang Won-Hee , Kim Kang Su
Published: February 2023

Regular safety inspections of existing reinforced concrete (RC) structures are required according to the regulations and criteria set by each country. In South Korea, the safety inspection regulations provided by the Korea Infrastructure Safety and Technology Corporation (KISTEC) are followed. These regulations were developed based on fuzzy theory to avoid subjective decisions, and provide standardized deterioration grades for member types, floors, and the entire structure. However, the safety inspection regulation by the KISTEC often provides unconservative evaluation results. In particular, as the importance factors of beam and slab members are set lower than those of other members, there are cases in which deteriorations occurring in beams and slabs are not properly reflected in the floor level evaluation. In this study, to overcome such limitations, case studies were carried out and modified importance factors for structural member types were proposed considering the failure probabilities of each member type based on the reliability theory. The importance modification factor was calculated based on the strength ratio of structural members so that the more dangerous the members are, the more impact they give on the evaluation. Overall, compared to the KISTEC method, the proposed method provided conservative but practical assessment results, and it was found that the proposed importance factors can be very useful to properly reflect the effects of damaged members on the deterioration status evaluation of the floors and the entire structure.
Anethole improves the developmental competence of porcine embryos by reducing oxidative stress via the sonic hedgehog signaling pathway
Authors: Joo Ye Eun , Jeong Pil-Soo , Lee Sanghoon , Jeon Se-Been , Gwon Min-Ah , Kim Min Ju , Kang Hyo-Gu , Song Bong-Seok , Kim Sun-Uk , Cho Seong-Keun , Sim Bo-Woong
Published: February 2023

Background

Anethole (AN) is an organic antioxidant compound with a benzene ring and is expected to have a positive impact on early embryogenesis in mammals. However, no study has examined the effect of AN on porcine embryonic development. Therefore, we investigated the effect of AN on the development of porcine embryos and the underlying mechanism.

Results

We cultured porcine in vitro-fertilized embryos in medium with AN (0, 0.3, 0.5, and 1 mg/mL) for 6 d. AN at 0.5 mg/mL significantly increased the blastocyst formation rate, trophectoderm cell number, and cellular survival rate compared to the control. AN-supplemented embryos exhibited significantly lower reactive oxygen species levels and higher glutathione levels than the control. Moreover, AN significantly improved the quantity of mitochondria and mitochondrial membrane potential, and increased the lipid droplet, fatty acid, and ATP levels. Interestingly, the levels of proteins and genes related to the sonic hedgehog (SHH) signaling pathway were significantly increased by AN.

Conclusions

These results revealed that AN improved the developmental competence of porcine preimplantation embryos by activating SHH signaling against oxidative stress and could be used for large-scale production of high-quality porcine embryos.
Endothelial function measured by peripheral arterial tonometry in patients with chronic myeloid leukemia on tyrosine kinase inhibitor therapy: a pilot study
Authors: Kaneko Tomohiro , Miyazaki Sakiko , Kurita Azusa , Morimoto Ryoko , Tsuchiya Shun , Watanabe Naoki , Takaku Tomoiku , Komatsu Norio , Minamino Tohru
Published: February 2023

Background

Arterial occlusive events are an emerging problem in patients with chronic myeloid leukemia (CML) receiving tyrosine kinase inhibitor (TKI) therapy. Endothelial cell damage is thought to play an important role in the development of vascular events. Measurement of the peripheral vasodilator response by peripheral arterial tonometry (PAT) has reportedly been useful in the non-invasive assessment of endothelial dysfunction. To date, no studies have assessed endothelial function using PAT in patients with CML receiving TKIs.

Method

We measured the reactive hyperemia index (RHI) using PAT in young patients with CML (men aged ≤ 55 years and women aged ≤ 65 years) receiving TKIs.

Results

Thirty patients with CML were examined (mean age, 43.5 ± 9.8 years; men, 57%). The median RHI was 1.81. Among these patients, 16.7% and 83.3% were taking imatinib and second- or third-generation TKIs, respectively. There were no differences in the baseline characteristics between the low RHI (< 1.67, n = 10), borderline RHI (≥ 1.67 and < 2.10, n = 14), and normal RHI (≥ 2.10, n = 6) groups. Serum uric acid (UA) levels and the RHI were significantly negatively correlated (r = -0.40, p = 0.029).

Conclusion

One-third of young patients with CML receiving TKI therapy were classified as having a low RHI. The RHI was negatively correlated with serum UA level. Larger prospective studies are necessary to examine whether the RHI predicts cardiovascular events in such patients.
Imaging dissociation in post-traumatic stress disorder
Authors: Quidé Yann
Published: February 2023

Symptom provocation paradigms have been successfully developed to identify the neural correlates associated with post-traumatic stress disorder (PTSD) symptoms, especially dissociative behaviours, but have critical limitations. Transiently stimulating the sympathetic nervous system and/or the hypothalamic–pituitary–adrenal (HPA) axis can enhance the stress response to symptom provocation and would help identify targets for personalised interventions.
When Muslim Rulers Were Like Hindu Gods
Authors: Everaert Christine
Published: February 2023

The 1930s Hindi short story “Mugaloṃ ne saltanat bakhś dī” (“The Mughals Gave the Sultanate Away”) by self-proclaimed apolitical author Bhagavatīcaraṇ Varmā offers an alternative version of how the British Crown took the rule of India away from the Mughal Empire. An in-depth analysis of this story written during the buildup to the decolonization of India evaluates how two different kinds of what is often referred to as “outside rulers” are depicted in this story: the Mughal emperors and the British colonial rulers. This case study assesses whether the story shows a different attitude toward Mughals and the centuries-old Muslim culture in India, compared to how both historic rulers are viewed and represented by right-wing Hindu nationalists: Muslim Indians seem to be made part of the “other” rather than a part of an inclusive interpretation of the Indian “self.”
Childhood Family Instability and Young-Adult Union Experiences: Black–White Differences in Outcomes and Effects
Authors: Bloome Deirdre , Fomby Paula , Zhang Yang
Published: February 2023

Today's young adults have diverse union experiences; some enter enduring marital or cohabiting unions at young ages, but many delay or dissolve their unions or remain single. Childhood family instability—defined as parents' transitions into or out of romantic coresidential unions—offers one explanation for why some people are more likely than others to enter and exit unions. We evaluate whether this family instability hypothesis—a union-specific version of the general hypothesis that instability affects people across multiple life domains—can explain Black and White young adults' union formation and dissolution. Using data from the Panel Study of Income Dynamics' Transition into Adulthood Supplement (birth cohorts 1989–1999), we find that the marginal effects of childhood family instability on cohabitation and marriage are weaker for Black than for White youth. Further, Black–White differences in childhood family instability's prevalence are small. Consequently, novel decompositions that account for racial differences in instability's prevalence and marginal effects reveal that childhood family instability contributes little to Black–White inequality in young adults' union outcomes. Our results challenge the generalizability of the family instability hypothesis across racialized groups in the union domain. Explanations for Black–White differences in young-adult marriage and cohabitation reside beyond childhood family dynamics.
Autism-linked NLGN3 is a key regulator of gonadotropin-releasing hormone deficiency
Authors: Oleari Roberto , Lettieri Antonella , Manzini Stefano , Paganoni Alyssa , André Valentina , Grazioli Paolo , Busnelli Marco , Duminuco Paolo , Vitobello Antonio , Philippe Christophe , Bizaoui Varoona , Storr Helen L. , Amoruso Federica , Memi Fani , Vezzoli Valeria , Massa Valentina , Scheiffele Peter , Howard Sasha R. , Cariboni Anna
Published: February 2023

Gonadotropin-releasing hormone (GnRH) deficiency (GD) is a disorder characterized by absent or delayed puberty, with largely unknown genetic causes. The purpose of this study was to obtain and exploit gene expression profiles of GnRH neurons during development to unveil novel biological mechanisms and genetic determinants underlying GD. Here, we combined bioinformatic analyses of immortalized and primary embryonic GnRH neuron transcriptomes with exome sequencing from GD patients to identify candidate genes implicated in the pathogenesis of GD. Among differentially expressed and filtered transcripts, we found loss-of-function (LoF) variants of the autism-linked neuroligin 3 (NLGN3) gene in two unrelated patients co-presenting with GD and neurodevelopmental traits. We demonstrated that NLGN3 is upregulated in maturing GnRH neurons and that NLGN3 wild-type, but not mutant, protein promotes neuritogenesis when overexpressed in developing GnRH cells. Our data represent proof of principle that this complementary approach can identify new candidate GD genes and demonstrate that LoF NLGN3 variants can contribute to GD. This novel genotype–phenotype correlation implies common genetic mechanisms underlying neurodevelopmental disorders, such as GD and autistic spectrum disorder.
Modern three-dimensional digital methods for studying locomotor biomechanics in tetrapods
Authors: Demuth Oliver E. , Herbst Eva , Polet Delyle T. , Wiseman Ashleigh L. A. , Hutchinson John R.
Published: February 2023

Here, we review the modern interface of three-dimensional (3D) empirical (e.g. motion capture) and theoretical (e.g. modelling and simulation) approaches to the study of terrestrial locomotion using appendages in tetrapod vertebrates. These tools span a spectrum from more empirical approaches such as XROMM, to potentially more intermediate approaches such as finite element analysis, to more theoretical approaches such as dynamic musculoskeletal simulations or conceptual models. These methods have much in common beyond the importance of 3D digital technologies, and are powerfully synergistic when integrated, opening a wide range of hypotheses that can be tested. We discuss the pitfalls and challenges of these 3D methods, leading to consideration of the problems and potential in their current and future usage. The tools (hardware and software) and approaches (e.g. methods for using hardware and software) in the 3D analysis of tetrapod locomotion have matured to the point where now we can use this integration to answer questions we could never have tackled 20 years ago, and apply insights gleaned from them to other fields.
The genome sequence of the Leopard Moth, Zeuzera pyrina (Linnaeus, 1761)
Authors: Boyes Douglas ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life programme,   Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective,   Tree of Life Core Informatics collective, Holland Peter W. H. ,   Darwin Tree of Life Consortium
Published: February 2023

We present a genome assembly from an individual male Zeuzera pyrina (the Leopard Moth, Arthropoda; Insecta; Lepidoptera; Cossidae). The genome sequence is 687 megabases in span. Most of the assembly is scaffolded into 31 chromosomal pseudomolecules, including the assembled Z sex chromosome. The mitochondrial genome has also been assembled and is 15.3 kilobases in length. Gene annotation of this assembly on Ensembl identified 22,738 protein coding genes.
HA2CR: Hierarchical Authentication Assisted Clustered Routing for Wireless Multimedia Sensor Networks
Authors: Jawwharlal R. , Devi L. Nirmala
Published: February 2023

Secure data transmission is the major issue in Wireless Multimedia Sensor Networks (WMSNs). One of the most well-known strategies that are essential in solving the privacy and security issues is access control and authentication. These techniques can stop malicious nodes from joining the network. However, because to the complexity of their encryption, they place an unsustainable computational burden on the energy-constrained sensor nodes. To ensure an efficient data access, this paper proposes a simple and effective authentication and access control mechanism called as Hierarchical Authentication Assisted Clustered Routing (HA2CR). Initially, HA2CR clusters the entire network into different clusters and then applies authentication at two stages; one is between Base Station and Cluster Head and another is between Cluster head and Cluster Member. The Second level authentication is a mutual authentication and allows both clustered and cluster member to check the authenticity of each of them. Simulation experiments with different scenarios show the performance effectiveness of HA2CR in the adversary identification and qualitative data delivery at base station. The average Malicious Detection Rate (MDR) and Packet Loss Rate (PLR) of proposed access control mechanisms observed as 92.4200%, and 6.1666 respectively. From the results the effectiveness of proposed method had proven in terms of larger MDR and lower PLR.
"Ponad" – "około" – "gdzieś" – "dobry", czyli o aproksymatorach na różnych piętrach nieprzedmiotowego poziomu języka
Authors: Doboszyńska-Markiewicz Katarzyna
Published: February 2023

Artykuł ukazuje polskie aproksymatory o różnych właściwościach formalnych jako ilustrację teorii klasyfikacji wyrażeń metatekstowych Jadwigi Wajszczuk. Są to dawne przyimki, zaimki i przymiotniki jakościowe, które przeszły z przedmiotowego na nieprzedmiotowy poziom języka (proces gramatykalizacji), zmieniając swoje cechy gramatyczne i znaczeniowe. Chociaż w klasyfikacji Wajszczuk aproksymatory zaliczone zostały do operatorów metapredykatywnych, część z nich wykazuje cechy metaoperatorów, a inne plasują się na pograniczu metatekstu i słownictwa przedmiotowego.
Cierpki smak rajskich jabłuszek. Nazwy przedmiotu w różnojęzycznych wersjach tekstu literackiego a rozbieżne interpretacje utworu
Authors: Dobrzyńska Teresa
Published: February 2023

W artykule omawiane są konsekwencje określonych językowych ujęć pewnego motywu w tekście literackim i jego przekładach. Analiza dotyczy nazw owoców pojawiających się w opowiadaniu Vladimira Nabokova pt. Signs and Symbols, które jest dostępne po polsku w dwóch wersjach: Znaki i symbole lub Sygnały i symbole. Zestawienie fragmentów tłumaczeń tego utworu z angielskim oryginałem ujawnia odmienne motywacje nazw tych samych owoców w różnych językach, a owe nazwy są nośnikami innych konotacji. Te różnice mogą stanowić podstawę rozbieżnych interpretacji utworu.
Szare strefy, w różnych odcieniach szarości: między wyrażeniami adwerbialnymi z poziomu przedmiotowego a nieprzedmiotowego oraz z poziomu metapredykatywnego a metatekstowego
Authors: Duraj-Nowosielska Izabela
Published: February 2023

Artykuł przedstawia przegląd wybranych badań nad metatekstem pod kątem opozycji między wyrażeniami adwerbialnymi z planu przedmiotowego i nieprzedmiotowego, a wśród nieprzedmiotowych – między wyrażeniami metapredykatywnymi a stricte metatekstowymi. Referuje się krótko ich ujęcie w polskich gramatykach oraz wymienia się najczęstsze kryteria ich rozróżniania. Wywód koncentruje się zwłaszcza na jednostkach z planu nieprzedmiotowego konformalnych z przysłówkami i na zjawiskach granicznych. Porusza się takie kwestie sporne jak: a) status wyrażeń gradacyjnych; b) regularne mechanizmy ewolucyjne rządzące przejściem od jednej klasy wyrażeń do drugiej, w tym kierunek motywacji w ramach metawyrażeń; c) status partykuł, dla których możliwe jest odtworzenie szerszego metakomentarza; d) status przysłówków względu; e) status przysłówków oceniających „zorientowanych na podmiot”, w pozycji tematycznej; e) status wybranych jednostek pod kątem ich przynależności do klasy metapredykatów bądź partykuł.
Słowo "tuż" wśród operatorów metapredykatywnych
Authors: Grochowski Maciej
Published: February 2023

Artykuł przedstawia charakterystykę właściwości gramatycznych i semantyczno-leksykalnych operatora metapredykatywnego tuż. Głównym celem artykułu jest ustalenie ograniczeń składniowych i leksykalno-semantycznych dotyczących prawostronnej pozycji syntaktycznej otwieranej przez operator tuż. W artykule uzasadnia się hipotezę, że tuż implikuje frazę przyimkową mającą znaczenie przestrzenne lub temporalne.
Semantyka i składnia polskiego predykatu "ale"
Authors: Topolińska Zuzanna
Published: February 2023

Polskie ale pojawia się w dwóch różnych typach kontekstów z dwoma różnymi funkcjami: 1. jako predykat z dwoma argumentami, +/- odpowiednik angielskiego but oraz 2. jako predykat z jednym argumentem, +/- odpowiednik angielskiego wtrącenia ‘what a ...!’. Fakt, że mutatis mutandis te same dwie funkcje pełni macedońskie ама, wskazuje na to, że mamy tu do czynienia w rozwojem właściwym dla języków słowiańskich.
Przywództwo polityczne: niektóre aspekty teoretyczne
Authors: Bankowicz Marek
Published: February 2023

POLITICAL LEADERSHIP: SOME THEORETICAL ASPECTS
Leadership is needed in each human community and common activity. It is most natural the area of politics, power and state. Politics is inseparably connected with leadership. Political leadership is unique power, it is a combination of leadership skills with the ability to inspire human behaviours in the social scale. Political leader has power over people as a result of their authority or by force. They can be either a democrat or a dictator. However, in all cases a political leader somebody more than ordinary politician, becoming positive or negative political giant.
Analisis Keberhasilan Hijab Indonesia: Strategi Marketing Buttonscarves Dalam Ekspansi Pasar Di Malaysia
Authors: Assegaf Rugaya
Published: February 2023

Hijab sebagai salah satu fashion halal yang dibutuhkan oleh para Muslimah mendatangkan berbagai pelaku usaha fashion halal menghadirkan berbagai brand fashion halal. Sebagaimana yang dilakukan oleh Linda Anggreaningsih melalui brand fashion halalnya yaitu buttonscarves. Buttonscarves dengan berbagai ciri khas dan kualitas tingginya mampu menarik minat para konsumen baik domestik maupun luar negeri seperti Malaysia, Singapura, serta Brunei Darussalam. Malaysia sebagai salah satu negara yang tingkat permintaan terhadap produk buttonscarves tinggi. Selain kualitas dan ciri khasnya yang dapat memikat minat masyarakat Malaysia, tentunya terdapat beberapa strategi yang mampu membawa keberhasilan bagi buttonscarves untuk menembus pasar Malaysia. Di era teknologi atau globalisasi ini strategi digital marketing merupakan salah satu strategi pemasaran yang dapat dikatakan ampuh untuk membawa keberhasilan buttonscarves untuk ekspansinya di negara Malaysia. Dalam penulisan artikel jurnal ini penulis menggunakan penelitian kualitatif dengan menggunakan instrumen studi literatur seperti e-book, e-journal, berita – berita online, serta berbagai situs online seperti media sosial, web.
APPLICATION OF UPWARD CONTINUATION FILTER FOR GEOMAGNETIC DATA INTERPRETATION IN GONDANG, BOJONEGORO AREA
Authors: Mustika Bohal Yolanda , M Mariyanto , Utama Widya
Published: February 2023

There are several manifestations of hot springs and mud pools in Gondang area, Bojonegoro, East Java, there were. This can be an indication of certain geological conditions. The description of these conditions can be done by measuring the geomagnetic method. A total geomagnetic anomaly has been generated through some geomagnetic values recorded in the region, which has been corrected using IGRF correction and diurnal correction. These steps were done to reduce external influences on the real value of the data. This research will use several variations of values in the Upward Continuation filter and one of them will be chosen to proceed as a model. Upward Continuation Filter is a process of transforming potential field data from a flat plane towards the higher plane. The purpose of this study is to compare the results of contour maps on several variations of the Upward Continuation value, to obtain the results of the separation of residual and regional anomalies using the Upward Continuation method, and to determine the value of the susceptibility distribution of inversion modeling in the Gondang region, Bojonegoro. Based on the results of data processing, it is known that the upward continuation value used is 100mdatum with a magnetic intensity value in the regional anomaly of 106.5 nT to 509.0. While the value of the residual anomaly is -232.1 nT to 159.4 nT. The 3D model was made using this residual anomaly which shows the low susceptibility distribution value in the range of -0.0298 to -0.0135 SI around the manifestation area, whereas the high susceptibility value has a value range of 0.0114 to 0.0466 SI interpreted as rock intrusion. Rock intrusion occurs within the area around the manifestation of mud pools.
ZONING PRONE TO LANDSLIDES THROUGH 3D VISUALIZATION USING GEO CAMERA APPLICATION IN CIKUYA VILLAGE, CULAMEGA DISTRICT, TASIKMALAYA REGENCY
Authors: Nur Aisah Siti , Ari Lesmana Vinki
Published: February 2023

Cikuya Village Culamega District Tasikmalaya District, West Java, landslide prone areas that cause material losses and fatalities. The landslide occurred because Cikuya Village is located in the South Mountain Zone with hilly morphology so that it has a steep slope. Other characteristics cause landslides due to high rainfall intensity, geological conditions, soil types, and land use that are not in accordance with the carrying capacity of the environment. Prevention efforts that can be done by measuring the characteristics of landslide prone and 3D visualization zoning maps using map overlays to produce zoning maps and land suitability using ArcGis 10.5 software and Geo Camera applications The results of this study show the characteristics that cause landslides are high rainfall intensity ranging from 2,203 - 3,054 mm / year, Steep slopes range from 8° - 40°, geological conditions (types of rocks) are divided into two types, namely sedimentary rocks and volcanic rocks, podsolic yellow red soil types that are not good in water escape, as well as land use that is not in accordance with the conditions and carrying capacity of the region. The results of the analysis of assessment, weighting and overlay zoning of disaster-prone areas are divided into three "non-prone" hazardous landslide zones with an area of 7,597 hectares, a "prone" zone with an area of 1,972,147 hectares, and a "very vulnerable" landslide vulnerability zone with an area of 256,968 hectares. Further analysis is that land suitability is divided into three "appropriate" zones with an area of 1,057,391 Hectares, "somewhat appropriate" with an area of 1,080,373 Hectares, and "incompatible" with an area of 98,948 Hectares. It is expected that the results of this study can be a reference for the community in recognizing landslide-prone zone areas in Cikuya Village, Culamega Subdistrict, Tasikmalaya Regency.
OPERATIONAL RISK ASSESSMENT SHIP CONSTRUCTION CAUSES MATERIAL IMPORT USING HOUSE OF RISK (HOR) AND CRITICAL CHAIN PROJECT MANAGEMENT: CASE STUDY IN GRESIK SHIPYARD INDUSTRY
Authors: Basuki Minto , Hildawan Mahendra Oka
Published: February 2023

This research is aimed to conduct risks assessment of ship building process in the part of materials procurement especially imported materials. The problem in Gresik shipyard industry is late material import, which impact the project delay. This research used House of Risk (HOR) combination and Critical Chain Project Management (CCPM) method analysis. Data analysis was obtained from data sample on new construction work of 2 x 1200 HP tug-boat at the Gresik Shipyard. The data used was related with materials procurement especially imported materials. The analysis used House of Risk (HOR) method and obtained 14 risk events which occurred in planning process and imported components for tug-boat 2x1200HP construction and 22 events as risk agent. There were 14 highest risks needing risk mitigation to reduce the impact. Rescheduling result of the material arrival and imported component used Critical Chain Project Management (CCPM) method. It was able to save time duration from activities schedule of 50%; previous schedule was 84 days become 42 days.
IDENTIFICATION OF BUILDING DENSITY USING UAV MAPPING METHOD IN CENTRAL KALIMANTAN REGIONAL SETTLEMENT INFRASTRUCTURE
Authors: Pongdatu Dennis Euro , Ghozy Salahudin Kholiq , Mokhamad Nur Cahyadi , Dwi Anggoro Primasetya
Published: February 2023

The increased population density in urban areas has caused buildings density that need to be identified to find out the development and growth of an area that requires clear planning. This research is using aerial mapping method to produce orthophoto area of Garuda - Tingang street. The on-screen digitation was carried out based on the aerial photo data result to determine the number of buildings and the total area of the building. Then, the classification of land cover vegetation and built up land were carried out. From the data processing, 1641 buildings were found on Garuda – Tingang street. The total area of the building is 35,478 hectares. Based on the Decree of the Minister of Public Works No.378/KPTS/1987, Appendix No.22 has a low building density level. The results of the classification state that the vegetation class has a total percentage of 42,969% and the built-up land class has the percentage of 57.031%.
NUMERICAL ANALYSIS SEAKEEPING AND MOTION SICKNESS INCIDENCE (MSI) ON HOSPITAL SHIPS BY ADDING FINS STABILIZER
Authors: Yasin M , Ariani Betty , Chandra Ariesta Riski
Published: February 2023

The development in maritime technology to improve ship performance and operations are growing and diverse. One of the developments carried out is the addition of fin stabilizers to improve ship safety as support for comfort and ships. This research analyzes the effect of variations in the shape of the fin stabilizer on the seakeeping and Comfort Index for Hospital Ships using Maxsurf Modeler software. The parameters used in this research are fins stabilizer Gemini 30, Gemini 50, and modular NR 30. While the variation of ship speed 0, 14, and 18 knots. The direction of the arrival of waves 0, 45, 90, 135, and 180 degrees. Based on data analysis carried out on ship motion, the NR 30 type fin stabilizer is far superior to the others with a maximum value of 4.04- degree roll movement, 0.543- degree pitch movement, and 0.4116 heave acceleration movement. Type NR 30 also has the best comfort on the moderate Motion Sickness Incidence (MSI) Criteria.
More Data on the Menu I/O Processors
Authors: Edwards Chris
Published: February 2023

Software might be eating the world but it’s getting fussier about what it runs on, with data streaming becoming the latest target for attention.
Development Kits – A Guide
Authors: Patrick Mark
Published: February 2023

IoT applications vary considerably, but a core set of functional requirements typically remain the same.
Colour Coding
Authors: Beck Chris
Published: February 2023

When AkzoNobel looked to set up a state-of-the-art paint plant near Newcastle, they soon realised the most important element was instilling the right culture, not necessarily focusing on the technology
The Future is in Safe Hands
Authors: Offord Adam
Published: February 2023

The fourth annual Manufacturing Champions Awards brought together some of the best talent from across industry for an afternoon of celebration and recognition of the teams and individuals that make UK factories great
Mind The Gender Gap
Authors: Lorely BURT Baroness
Published: February 2023

Women are being put off a career in manufacturing and engineering by a perceived lack of inclusivity, with females making up fewer than 10% of the industry’s workforce. Is a more radical approach needed to redress the balance?
Eat, Sleep, Learn, Repeat
Authors: Offord Adam
Published: February 2023

Manufacturers and their teams from all four corners of the UK descended on Coventry in November to talk business and best practice at the second annual Manufacturing Management Show
Crafting The Future
Authors: Offord Adam
Published: February 2023

Industry is facing many challenges, including a skills shortage, Brexit uncertainty and Industry 4.0 implementation. Manufacturing Management visited two businesses within the UK’s craft sector to find out how they are coping and what the future may hold
Stop and Go
Authors: Beck Chris
Published: February 2023

Electric motor manufacturer YASA recently opened a new, state-of-the-art factory near Oxford. MM spoke to the firm’s CEO, Chris Harris, about the challenges that come with opening a new site in the UK today
Around the Regions: The North West
Authors: Durkin Joel
Published: February 2023

As part of a new series looking at the challenges facing the manufacturing industry around the UK, EEF, the manufacturers’ organisation, examines how the country’s regions have been faring so far in 2018
Eating apart together: how vegetarian and meat eating students manage commensality in a flexitarian age
Authors: Veen Esther J. , Dagevos Hans , Michielsen Yolie J.E. , de Vrieze Anke G.M. , Riedel Selke E.
Published: February 2023

We are living in a flexitarian age, in which reduced meat eating and vegetarianism are normalising, while simultaneously meat eating is still the norm in Dutch society. A resulting individualisation of diets begs the question whether and how omnivores and veg*ns living together maintain commensality. Based on interviews with 119 young people living in shared households – made up of both veg*ns and omnivores – we investigate how these young adults shape and manage their shared meals. Our results show that veg*ns and meat eaters maintain commensality by, first, using a number of practical strategies that result in meals that are suitable to those different diets, and, second, creating a new norm that defines the diet as an individual choice so as to manage potential conflicts around clashing norms. This results in an active upkeep of tolerance in which veg*nism, meat eating and associated ethical-moral considerations are not discussed. The acceptance of (specifically) vegetarianism, the limited social tensions between meat lovers, meat reducers and meat avoiders, and our finding that people find ways to eat – apart – together, hints at optimism for the future.
Aspectos bioéticos da utilização de sistemas de inteligência artificial no campo da saúde: um estudo exploratório
Authors: Duarte Evelise Scaraboto , De Moura Fagner Sutel , De Oliveira Leonardo Pestillo , Garcia Lucas França
Published: February 2023

Objetivo: analisar a percepção de usuários de redes sociais a respeito da utilização de sistemas de IA no campo da saúde e os aspectos bioéticos associados a essa utilização. Método: Estudo de método mistos, do tipo descritivo-exploratório. O percurso metodológico foi dividido em duas etapas: (1) levantamento de informação a respeito dos principais aspectos bioéticos envolvidos na utilização de IA e (2) elaboração dos cenários de tomada de decisão. Os dados quantitativos foram analisados por meio de estatística descritiva a fim de caracterizar a amostra do ponto de vista sociodemográfico, bem como caracterizar o perfil de tomada de decisão da amostra com relação às questões bioéticas associadas à utilização de sistemas de IA. A análise dos dados qualitativos foi realizada por meio da análise de conteúdo de Bardin. Resultados: com relação ao perfil sociodemográfico pode-se observar uma amostra de adultos, do sexo feminino, com curso superior completo. Com relação às preocupados éticas associadas aos cenários aplicados, as principais preocupações foram em primeiro lugar a privacidade e confidencialidade dos dados, seguido de preocupações relacionadas à responsabilidade associada a utilização destas tecnologias, bem como ao consentimento informado. Conclusão: Desta forma, destaca-se a importância de novos estudos empíricos exploratórios como este, avaliando a percepção, atitudes e opiniões de públicos especializados, como profissionais da área da saúde, do direito, das humanidades, a fim de se obter evidências concretas para a elaboração de programas de gestão e governança dos sistemas de IA, sobretudo no cenário brasileiro, de escassez de recursos.
Filiación, gestación por sustitución y derecho internacional privado: la Sentencia del Tribunal Supremo español 277/2022 a la luz de la doctrina del Tribunal Europeo de Derechos Humanos
Authors: Pino Ávila Alonso
Published: February 2023

El Tribunal Supremo admite la reclamación de la paternidad biológica y el expediente de adopción como procedimientos idóneos para el reconocimiento de la filiación derivada de una gestación por sustitución celebrada en el extranjero, al mismo tiempo que deniega su reconocimiento cuando haya sido reclamada mediante la solicitud de la transcripción del certificado registral extranjero o por posesión de estado. Esta doctrina es compatible con la jurisprudencia del Tribunal Europeo de Derechos Humanos que obliga a los Estados a reconocer la filiación derivada de una gestación por sustitución cuando exista un vínculo genético entre el menor y los padres de intención, así como a proteger el interés superior del menor cuando exista vida familiar. Esta doctrina jurisprudencial pretende proteger los derechos de la madre gestante y el interés superior del menor; sin embargo, una protección eficaz de ambos solo puede venir desde un convenio de derecho internacional privado que regule los requisitos para el reconocimiento de la filiación por parte de aquellos Estados que niegan validez a los contratos de gestación por sustitución, de manera que los derechos humanos y el interés superior del menor sean garantizados.
CAD tools for integrated optical design
Authors: Young Terry
Published: February 2023

Design tools based on advanced numerical techniques have been making an increasing impact on electromagnetic design for the past two decades. The impact of such methods in structural and solid modelling are, of course, well known.
Design and Fabrication of Integrated-Optic Sensors
Authors: Haruna M.
Published: February 2023

In the past more than ten years, a variety of optical waveguide sensors have been reported so far, i.e, temperature, pressure and humidity sensors [1].
Design of Optical Devices through the Finite Element Method
Authors: Zoboli M. , Selleri S. , Di Pasquale F.
Published: February 2023

Recent developments in optical fabrication technology and optoelectronics have provided an abundance of new optical elements whose analysis requires design techniques and powerfull numerical methods.