bluuebunny/crossref_metadata_2025 huggingface dataset:
Interprofessional communication and user participation in the Family Health Strategy
Authors: Prado Crislaine Loqueti Santos Rainho , Peduzzi Marina , Agreli Heloise Lima Fernandes , Rodrigues Lívia Bezerra
Published: January 2024

Abstract This study deals with collaborative competencies to strengthen teamwork and interprofessional collaboration in Primary Health Care services, supported by the framework of the health work process, interprofessional work and competencies. Its objective is to understand the conceptions and experiences of professionals from the Family Health Strategy teams regarding the core collaborative competencies: interprofessional communication and patient-centered care. This is an exploratory and interpretative qualitative study. A secondary database was used, with 34 interviews conducted with professionals from the teams of three health units located in two municipalities. Thematic content analysis was adopted, with support by the WebQDA software. The findings show the professionals’ understanding of collaborative competencies as complementary and as impossible to being treated independently. Interprofessional communication is recognized as a focus on meeting the user’s health needs, limited by unsatisfactory working conditions. Patient-centered care appears weak, since the sense of user participation prevails as a transfer of responsibility for their care to professionals and in a minority way, as sharing the construction of the care plan.
Work process and psychological suffering of primary care physicians during the COVID-19 pandemic
Authors: Macedo Maurício Roberto Campelo de , Macedo Isa Maria Hetzel de , Cruz Ruy Ribeiro Moraes , Dantas Gabrielle Karla de Oliveira , Augusto Isabela Coronelli , Lopes Izadora Freitas
Published: January 2024

Abstract Work organization and process are privileged spaces to recognize the forces that lead to psychological suffering. This study aims to analyze the perceptions of physicians of primary health care, who work in the More Doctors Program, on the relation between psychological suffering and work process during the COVID-19 pandemic. This research was conducted with a case study using qualitative data collection, description, and analysis. An intentional sample was selected in accordance with the theoretical saturation technique. Information was collected by semi-structured interviews, following a script built to meet the objectives of this research. The analysis of interviewees’ discourse articulated categories of analysis drawn from five thematic axes with points of articulation between them, consensuses and contradictions that give meaning to the visions and positions of the actors in health. Results evinced the pandemic as a health and traumatic catastrophe, resizing the work process and contributing to overload, conflicts, fear, feelings of helplessness, and psychological suffering. Numerous shortcomings, infrastructure problems, bureaucracy, political interference, mismatch between training and practice also contributed to this suffering.
Processo de trabalho e sofrimento psíquico de médicos da atenção primária na pandemia do covid-19
Authors: Macedo Maurício Roberto Campelo de , Macedo Isa Maria Hetzel de , Cruz Ruy Ribeiro Moraes , Dantas Gabrielle Karla de Oliveira , Augusto Isabela Coronelli , Lopes Izadora Freitas
Published: January 2024

Resumo A organização e o processo de trabalho são espaços privilegiados para reconhecer as forças que levam ao sofrimento psíquico. Este artigo pretende analisar as percepções de médicos(as) da atenção primária à saúde, que atuam no Programa Mais Médicos, sobre as relações entre sofrimento psíquico e processo de trabalho, no contexto da pandemia do coronavirus. Esta pesquisa foi realizada por meio de um estudo de caso, utilizando métodos e técnicas qualitativas para a coleta, descrição e análise dos dados. Foi selecionada uma amostra intencional em conformidade com a técnica de saturação teórica. A coleta de informações foi realizada com ajuda de entrevistas semiestruturadas, seguindo um roteiro construído para atender aos objetivos desta pesquisa. A análise do discurso dos entrevistados articulou categorias de análise extraidas de cinco eixos temáticos que têm pontos de articulação entre si, com consensos e contradições que dão sentido às visões e posições dos atores no campo da saúde. Os resultados evidenciaram a pandemia como catástrofe sanitária e traumática, redimensionando o processo de trabalho e contribuindo para a sobrecarga, conflitos, medo, sentimento de desamparo e sofrimento psíquico. Inúmeras carências, problemas de infraestrutura, burocracia, interferências políticas, descompasso entre a formação e a prática também contribuiram para esse sofrimento.
Sentidos de (des)regulação do mercado de trabalho no setor da saúde em Portugal
Authors: Marques Ana Paula
Published: January 2024

Resumo Reconhece-se a escassez de investigação sobre o mercado de trabalho do setor da saúde. Com a ampliação dos fenómenos de precarização objetiva e subjetiva, decorrente da agenda neoliberal de mercadorização do valor do trabalho e das reformas gestionárias da saúde, a “atipicidade” dos vínculos laborais e a “insegurança” de vida dos profissionais de saúde têm introduzido lógicas de segmentação e polarização do mercado de trabalho. Este deixa de ser palco apenas de mercados protegidos, passando a incluir mercados desregulados e “híbridos”. Neste artigo pretende-se explorar os sentidos, com implicações desiguais, da (des)regulação do mercado de trabalho no setor da saúde em Portugal. Parte-se de fontes secundárias e de investigação qualitativa suportada em 32 entrevistas semiestruturadas feitas com profissionais de saúde, que atestam o fenômeno da crescente individualização e subcontratação laboral. Propõe-se um modelo conceitual que capte os sentidos de (des)regulação, num continuum de regulação social e mobilidade profissional, traduzindo mercados protegidos (profissionais e internos) e mercados híbridos (terciarizados e secundários) a serem testados por confronto empírico e investigação futura.
As escolas de saúde do SUS: razões de ser e contribuições
Authors: Pontes Haroldo Jorge de Carvalho , Castro Janete Lima de
Published: January 2024

Resumo Neste artigo procura-se conhecer a percepção dos secretários estaduais de saúde, de seus docentes e dirigentes sobre as contribuições das escolas estaduais de saúde pública para o Sistema Único de Saúde (SUS). Sendo uma pesquisa de abordagem qualitativa, foram entrevistados os secretários estaduais de saúde, além dos dirigentes e docentes dessas escolas. O conteúdo das entrevistas foi analisado à luz do referencial de Bardin. Foram ressaltadas as contribuições das escolas para o SUS, demonstrando o papel estratégico que elas desempenham, destacando-se a provisão de profissionais formados nessas escolas e que ocupam cargos de gestão do SUS; o apoio técnico ofertado aos municípios e o reconhecimento dos trabalhadores pelo trabalho desenvolvido por essas escolas. No entanto, é necessário observar que essas instituições enfrentam dificuldades, em especial a insuficiência de recursos financeiros e humanos. As escolas são estratégicas para o SUS, sendo instrumentos fundamentais para manter a política de educação permanente em saúde e para qualificar a força de trabalho em saúde. As dificuldades relatadas indicam a necessidade de priorizar de fato as políticas de educação permanente e de qualificação profissional voltadas para o trabalhador da saúde.
Implementation barriers to interprofessional education: an analysis of the Educação pelo Trabalho para a Saúde Program (PET-Saúde)
Authors: Souza Rachel Brinco de , Magnago Carinne , França Tania , Freire Filho José Rodrigues
Published: January 2024

Abstract This study analyzes the barriers undergraduate health courses participating in the Educação pelo Trabalho para a Saúde (PET-Saúde), in Rio de Janeiro, face to implement interprofessional education. An exploratory and qualitative case study was conducted with 32 participants from PET-Saúde, a program that promotes curricular changes in undergraduate health courses. Data were collected in 2020 by means of individual interviews. Thematic analysis of the data identified sociopolitical, institutional, and relational barriers. Degradation of the health system and the regional violence hindering healthcare activities were the main sociopolitical barriers. In turn, institutional barriers included curriculum rigidity, university administrator turnover, and lack of evaluation methods for innovative interprofessional education. As for relational barriers, professional silos hindering collaborative efforts, top-down power hierarchies resistant to feedback, and unsatisfactory communications among stakeholders were the main complaints. Overcoming these barriers requires intersectoral public policies, greater integration among professionals, healthcare, and education systems, and recognizing that interprofessional education can improve public health, reduce healthcare costs, and ensure professional satisfaction and work safety.
The management of the COVID-19 pandemic and its repercussions for the SUS manager
Authors: Castro Janete Lima de , Magnago Carinne , Belisário Soraya Almeida , Ribeiro Samara da Silva , França Tania , Pinto Isabela Cardoso de Matos
Published: January 2024

Abstract This article discusses the challenges faced by the state managers of the Brazilian National Health System (SUS) in the context of the COVID-19 pandemic and the consequences for their personal lives. From interviews with state managers, it became evident that the pandemic implied the replanning of health actions and services, the structuring of new hospital services and beds, the use of telemedicine, and the hiring and training of professionals. It also exposed the lack of integrated policies and national coordination, which led to states adopting different strategies. These factors, as well as the politicization of the pandemic, the denial of the disease, and the attempt of the federal government to impose ineffective treatments for COVID-19 were considered among the greatest difficulties experienced by managers. Managing the SUS became a risky exercise, with deleterious repercussions not only for themselves and their management, but also for their families and friends. If, on the one hand, the strenuous context affected the managers’ physical and mental health, who began dealing with overweight, anxiety, and anguish, on the other hand, it was a source of motivation for catalyzing solidarity, empathy, and sharing among political actors.
The impact of autonomous vehicles on the performance of steel bridge deck pavement
Authors: Liang Kaidi , Zhu Jikai , Qian Zhenning , Yang Wenyuan
Published: January 2024

The widespread application of autonomous driving technology has become a prominent trend in the transportation industry. The purpose of this study was to investigate the impact of the lateral distribution pattern of autonomous vehicles (AVs) on steel bridge deck pavements (SBDP), with the aim of providing reliable theoretical support for future bridge deck pavement management and operation. A mixed traffic flow lateral distribution model was established and the Nanjing Yangtze Fourth Bridge was used as a case study. A corresponding finite-element model (FE) was constructed and Abaqus FE software was used to analyse rutting depths under different scenarios. The simulation results demonstrated that, under the zero distribution mode, a rational layout of AVs can significantly alleviate rut formation. Conversely, an unreasonable layout will reduce the service life of SBDP. Comparing the lateral distribution patterns of different vehicles, both the normal distribution and uniform distribution patterns exhibited positive effects on the SBDP. However, there was no significant difference in the magnitude of this positive impact between the two modes. This research not only fills the gap in the study of AV impact on SBDP but also proposes management methods for AVs.
Enriched Single-Nucleus RNA-Sequencing Reveals Unique Attributes of Distal Convoluted Tubule Cells
Authors: Su Xiao-Tong , Reyes Jeremiah V. , Lackey Anne E. , Demirci Hasan , Bachmann Sebastian , Maeoka Yujiro , Cornelius Ryan J. , McCormick James A. , Yang Chao-Ling , Jung Hyun Jun , Welling Paul A. , Nelson Jonathan W. , Ellison David H.
Published: January 2024

Significance Statement

High-resolution single-nucleus RNA-sequencing data indicate a clear separation between primary sites of calcium and magnesium handling within distal convoluted tubule (DCT). Both DCT1 and DCT2 express Slc12a3, but these subsegments serve distinctive functions, with more abundant magnesium-handling genes along DCT1 and more calcium-handling genes along DCT2. The data also provide insight into the plasticity of the distal nephron-collecting duct junction, formed from cells of separate embryonic origins. By focusing/changing gradients of gene expression, the DCT can morph into different physiological cell states on demand.

Background

The distal convoluted tubule (DCT) comprises two subsegments, DCT1 and DCT2, with different functional and molecular characteristics. The functional and molecular distinction between these segments, however, has been controversial.

Methods

To understand the heterogeneity within the DCT population with better clarity, we enriched for DCT nuclei by using a mouse line combining “Isolation of Nuclei Tagged in specific Cell Types” and sodium chloride cotransporter–driven inducible Cre recombinase. We sorted the fluorescently labeled DCT nuclei using Fluorescence-Activated Nucleus Sorting and performed single-nucleus transcriptomics.

Results

Among 25,183 DCT cells, 75% were from DCT1 and 25% were from DCT2. In addition, there was a small population (<1%) enriched in proliferation-related genes, such as Top2a, Cenpp, and Mki67. Although both DCT1 and DCT2 expressed sodium chloride cotransporter, magnesium transport genes were predominantly expressed along DCT1, whereas calcium, electrogenic sodium, and potassium transport genes were more abundant along DCT2. The transition between these two segments was gradual, with a transitional zone in which DCT1 and DCT2 cells were interspersed. The expression of the homeobox genes by DCT cells suggests that they develop along different trajectories.

Conclusions

Transcriptomic analysis of an enriched rare cell population using a genetically targeted approach clarifies the function and classification of distal cells. The DCT segment is short, can be separated into two subsegments that serve distinct functions, and is speculated to derive from different origins during development.
El nuevo constitucionalismo latinoamericano, presidencialismo y revocatoria del mandato
Authors: Ospina Molina Pablo Sergio
Published: January 2024

América Latina, un continente que ha pasado de una senda historia constitucional antidemocrática, que a finales del Siglo XX y principios del Siglo XXI, ha propendido por generar constituciones democráticas, siendo Colombia, Venezuela, Ecuador y Bolivia los abanderados de este modelo que manteniendo su bicentenaria tradición presidencialista, se ha preocupado por tratar de controlar el desbordado presidencialismo (hiperpresidencialismo) y en consecuencia tratar de mantener el sistema de frenos y contrapesos, en el presente artículo, revisaremos uno de esos mecanismos como lo es la Revocatoria Directa, mirando la figura desde un punto de vista doctrinario siendo una investigación jurídica, revisando el tema de la mano con aspectos propuestos por los mismos gobiernos, la rama legislativa y los pronunciamientos de los tribunales constitucionales, evidenciando los problemas que en la práctica evidencia este mecanismo de participación democrática y como este afecta el ejercicio democrático.
Balıkesir Balya Pb-Zn cevherinden hidrometalurjik yöntemlerle Zn kazanımının araştırılması
Authors: Tombal Tuğba Deniz , Kurşun Ünver İlgin
Published: January 2024

Bu çalışmada Balıkesir-Balya Pb-Zn cevherlerinden Zn’nin asit liçi yöntemi ile kazanımı araştırılmıştır. Sülfürik asit (H2SO4), hidroklorik asit (HCl) ve nitrik asit (HNO3) ile gerçekleştirilen kimyasal çözündürme deneylerinde; 75-106-150 µm tane boyutu, %5-10-15-20-25 katı oranı, 30-60-120-180-240 dak. liç süresi, 0,25-0,5-1-2-5 M asit dozajı ve 30-40-50-60-70 oC pülp sıcaklığı parametreleri denenmiştir. Zn için optimum sonuçlar 75 µm (H2SO4 ve HNO3) ve 106 µm (HCl) tane boyutu, %15 (H2SO4), %25 (HCl) ve %20 (HNO3) katı oranı, 120 dak. (H2SO4) ve 60 dak. (HCl ve HNO3) liç süresi, 0,5 M (H2SO4 ve HCl) ve 1M (HNO3) asit dozajı ve 50 oC (H2SO4 ve HNO3) ve 70 oC (HCl) pülp sıcaklığı şartlarında elde edilmiştir. Belirtilmiş olan bu optimum koşullarda gerçekleştirilen deneyler sonucunda sırasıyla %97,32, %96,38 ve %96,06 Zn çözünme verimleri elde edilmiştir. Ayrıca bu çalışmada her üç asit için de sıcaklığa bağlı kinetik analizler gerçekleştirilmiştir. Her asit için -106+75 µm tane boyutu, 1 M asit dozajı, %20 katı oranı, 0-30 dak. liç süresi, 50-90 oC pülp sıcaklığı, 250 dev./dak. karıştırma hızı koşullarında deneyler gerçekleştirilmiştir. H2SO4, HCl ve HNO3 deneyleri için liç kinetiği incelendiğinde farklı sıcaklıklarda elde edilmiş olan çözünme verimleri grafiklendirilerek elde edilen doğruların eğiminden görünür hız sabitleri ve korelasyon katsayıları hesaplanmıştır. Bu değerler incelendiği zaman Zn çözünmesinin her üç asit ortamında da Küçülen Çekirdek Modeli’nde difüzyon kontrollü modele uyduğu görülmüştür. Zn liçi çözünme verimlerinde farklı sıcaklıklar için elde edilen Arrhenius grafiği doğrusunun eğiminden aktivasyon enerjileri H2SO4 için 3,615 kJ/mol, HCl için 4,811 kJ/mol ve HNO3 için de 4,736 kJ/mol olarak hesaplanmıştır.
CNTFET VDGA tabanlı ultra düşük güç düşük voltaj yüksek frekanslı filtre uygulamaları
Authors: Sunca Şeyda , Alçı Mustafa
Published: January 2024

MOSFET boyutlarının ölçeklendirilmesinde sınır değere yaklaşılmasıyla birlikte birçok problem ortaya çıkmıştır. MOSFET’in boyutlarının küçültülmesiyle ortaya çıkan kısa kanal etkileri ve azaltılmış geçit kontrolü gibi birçok problemler için alternatif çözüm yolları araştırılmıştır. Karbon Nanotüp Alan Etkili Transistör (CNTFET- Carbon Nanotubes Field Effect Transistors) üstün elektriksel ve mekaniksel özellikleri ile MOSFET’ in yerini alacak en uygun alternatif olarak düşünülmektedir. Bu çalışmada, 32 nm CNTFET kullanılarak Voltaj Farkı Alan Kazanç Kuvvetlendirici (VDGA-Voltage Differencing Gain Amplifier) yapısının benzetim çalışmaları yapılmıştır. Buna ek olarak CNTFET VDGA yapısı ile üç girişli tek çıkışlı filtre yapısı sunulmuştur. ±0.3V düşük besleme voltajında ve 1µA düşük kutuplama akımında gerçekleştirilen filtre yapısı, CMOS VDGA ile gerçekleştirilen filtre yapısına kıyasla 22,909 MHz gibi daha yüksek merkez frekansına sahiptir. Ayrıca CNTFET VDGA yapısıyla gerçekleştirilen filtre 8,3412 µW düşük güç tüketimine sahiptir.
Fındık yağından elde edilen biyodizelin karakteristik özelliklerine ultrasonik banyo uygulamasının etkilerinin araştırılması
Authors: Şimşek Fadime
Published: January 2024

Bu çalışmada bitkisel kökenli fındık yağına baz katalizle transesterifikasyon işlemi uygulanarak, gliserinle biyodizelin ayrışması sağlanmıştır. Çalışmada üretilen biyodizele, saflaştırılmak ve reaksiyon verimini artırmak amacıyla ultrasonik banyo muamelesi gerçekleştirilmiştir. Elde edilen biyodizel numunelerine farklı sürelerde ultrasonikasyon uygulanarak, biyodizelin yapısında meydana gelen kimyasal değişikliklerin, fiziksel özelliklere etkisi araştırılmıştır. Öncelikle, serbest yağ asitliği tespit edildikten sonra rafine fındık yağı, NaOH katalizörlüğünde 55°C'de metil alkol ile transesterifikasyon reaksiyonu gerçekleştirilmiştir. Akabinde, biyodizel örneklerine belirli sürelerde ultrasonik banyo işlemi uygulanarak biyodizelin yapısına ve karakteristik özelliklerine etkisi test edilmiştir. Sonuç olarak, ultrasonik banyo işlemi görmüş fındık yağı biyodizel numunelerinin FTIR analizleri, sonikasyon uygulama süresinin transesterifikasyonu doğrudan etkilediğini göstermiş, düşük uygulama sürelerinde reaksiyon verimi artarken yüksek uygulama sürelerinden biyodizel veriminin düştüğü belirlenmiştir. Bu yöntem, biyodizel eldesinde en önemli sorun olan uzun yağ zincirlerinin kısaltılmasında kimyasal yöntemler kadar iyi bir etki göstermiştir. Yöntemin yüksek verim ile daha kısa zincirli yağ asidi-metil esterlerinin oluşumunu sağladığı ve yardımcı kimyasalların uzaklaştırılması adımını içermemesi nedeniyle hızlı ve yüksek uygulama potansiyeline sahip olduğu görülmüştür.
Geleneksel ve flaş sinterleme yöntemlerinin ZrO2-SnO2 nanokompozitlerin özelliklerine etkisi
Authors: Çetinkaya Zeynep
Published: January 2024

ZrO2-SnO2 nanokompoziti, elektro-eğirme tekniği ile nanofiber (NF) formunda hacimce (%v/v) üç farklı oranda üretilmiştir. NF’lerin mikro yapısı ve morfolojik karakterizasyonu, ZrO2-SnO2-ZrSnO4’ün üçlü sistemini ortaya koymaktadır. Ayrıca, NF’lerin bileşim oranı değiştirildiğinde, hem bant aralığı hem de elektriksel (flaş) sinterleme (ES veya FS) olayının sıcaklık ve sinter süresi değişimini etkilemiştir. FS deneyleri, termal (844-878 oC) ve elektrik alanı (420V/mm) altında 3,77mA/mm2 akım kesiminde kullanılmıştır. 1,58W/mm3 maksimum güç absorpsiyonu ile 80 saniyeden daha kısa bir sürede oldukça yoğun nanokompozitler elde edilmiştir. Düşük sinterleme sıcaklığı ve süresi sayesinde nanokompozitlerin nano yapılı yüzey morfolojisi elde edilmiştir. FS işleminin yanı sıra ZrO2-SnO2-ZrSnO4 KNF’leri geleneksel sinterleme (GS) yöntemi kullanılarak 1200 oC’de 1 saat süre ile sinterlenmiştir. Bu çalışmada, sinterleme tekniklerindeki farklılığın sinterlenme sıcaklığına ve süresine bunun yanında yoğunluk ve sertlik gibi özelliklerine etkileri incelenmiştir. Kompozisyondaki Sn miktarı (%v/v) arttıkça yoğunluk artmakta ancak sertlik değeri düşmektedir. ZrO2-SnO2-ZrSnO4 KNF’lerinde FS işlemi ile GS’ye göre daha yoğun ve daha sert kompozisyonlar elde edildiği kanıtlanmıştır. Bu sonuçların tamamı değerlendirildiğinde, sentezlenen nanokompozitlerin, model organizmada antimikrobiyal etkisi ve toksik olmaması nedeniyle diş implantları gibi sağlık sisteminde geçerli bir aday olarak kullanılabileceğine inanılmaktadır.
EVTrap non-antibody affinity bead protocol for EV isolation from urine, compatible with SiMOA assays v1
Authors: not provided andrew.west , not provided yuan.yuan
Published: January 2024

A modified protocol using EVTrap beads (Tymora Analytical) to isolate EVs from human urine, and subsequent processing, for detection of proteins using SiMOA or comparable ELISA-based protocols.
ECIS Data Analysis for Stimulation of Human Pulmonary Microvascular Endothelial Cells (HPMECs) with Human Serum v2
Authors: Bokoch Michael
Published: January 2024

Sera from patients in our UCSF Liver Transplant Biobank are used to stimulate human pulmonary microvascular endothelial cells (HPMECs) grown to confluency on ECIS platform. This protocol prospectively defines the plan for data analysis from these experiments.
Integrated Indexing One-Step RT-PCR with NEB LunaScript:Influenza A Virus Sequencing with Native Oxford Nanopore Software Compatibility v1
Authors: Srikanth Abhinaya
Published: January 2024

This integrated indexing RT-PCR protocol has been optimized for whole genome sequencing of influenza A virus (IAV) using Oxford Nanopore’s Ligation Sequencing Kit V14. The updated protocol is an optimization of an early approach used across several laboratories for research purposes, and uses New England Biolabs reagent sets including LunaScript‱ Multiplex One-Step RT-PCR (#E1555), NEBNext dA-Tailing Module (E6053), and the NEBNext Quick Ligation Module (E6056). Previously demonstrated IAV whole genome sequencing approaches for Oxford Nanopore used Superscript III/Platinum Taq RT-PCR reagents input into the Native Indexing reagent set, which results in a complex, multi-step process that requires more than a full working day to carry out. The improved integrated indexing protocol can be completed within a working day, and incorporation of the molecular index during first-strand cDNA synthesis in the RT-PCR step reduces the likelihood of sample cross-contamination during handling. Recent improvements to the approach additionally include Oxford Nanopore defined constant regions that are required for full compatibility with default informatics packages. This update now enables native demultiplexing within either Guppy or Dorado, effectively serving as a “molecular patch” where previous implementations required software modifications that were often broken by silent updates to MinKNOW. As designed, this protocol has potential for extension to other viruses of interest by modifying primer sets. A simplified excel workbook is provided for design of new primer sets, for which the first worksheet requires input of gene-specific primer sets, the second worksheet provides fully constructed primers, and the third can be exported directly for submission to a primer synthesis vendor such as IDT DNA.
PSYCHOPHONOSEMANTICS OF PROPER NAMESIN VASYL ZEMLIAK’S NOVEL “FLOCK OF SWANS”AS A SIGN OF THE NATIONAL ARCHETYPE SYSTEMOF UKRAINIANS
Authors:   Vasyl Stefanyk Precarpathian National University, Ivano-Frankivsk, Ukraine, Kholod Oleksandr
Published: January 2024

The purpose of the study was to clarify the psychophonesemantics of proper names in Vasyl Zemliak’s novel “Flock of Swans” as a sign of the national archetype system of Ukrainians. Among the methods, the concept of holism (general method) was chosen; analysis and synthesis, deduction and induction, quantitative-qualitative method, method of generalization and classification (general scientific methods) and survey, content analysis by the unit “word” (industry methods). The methodology involved writing 46 proper names from the text of Vasyl Zemliak’s novel “Flock of Swans” in the survey form and sending them to the respondents thanks to the social networks “Facebook”, “Telegram”, “Viber” and free e-mail “Freemail”. The received 23 completed forms were analyzed. The results of the research made it possible to state that the proper names found in Vasyl Zemliak’s novel “Flock of Swans” have psychophonosemantic features. The mentioned signs are similar to those inherent in the definitions and descriptions of the signs of the system of archetypes, which were proposed at one time by Ukrainian writers, teachers, psychologists, encyclopedists, culturologists and philosophers H. Skovoroda, M. Gogol, P. Kulish, P. Yurkevich, O. Kulchytskyi, D. Chyzhevskyi.
Historical Criminology as a Methodological Approach to the Study of Crime Problems
Authors: Pudovochkin Yu. E. , Babaev M. M.
Published: January 2024

The principle of historicism as a basic methodological requirement of dialectics has not received an independent theoretical interpretation in domestic criminology. Historical criminology can be considered its emanation in modern English-language criminology, which has established itself in recent decades as an authoritative methodological approach to the study of crime and related problems. Based on several authoritative publications, primarily the monograph “Historical Criminology” by D. Churchill, G. Yeomans and I. Channing, it seems possible to describe the main characteristics of this approach. In accordance with it, historical criminology can be thought of not as a subject area of criminological research and not as a criminological school, but as a set of requirements for the study of all components of the subject of criminology. They are based on two basic theoretical concepts: “historical time” and “historical thinking”. The main characteristics of historical time — change, eventfulness, fluidity, tension and embodiment — set the appropriate rules for conducting criminological research, including: the study of criminologically significant trends in the long term; attention to specific criminal and social events not only as a point that changes trends, but also as an independent temporal unit; using the complexity principle to explain crime. In the process of implementing these requirements, it is necessary to take into account that the present studied by criminologists is a multi-layered social phenomenon that combines not only recorded events and facts of today, but also persistent echoes of the past and anticipations of the future. It is the recognition of the unity of the past, present and future that serves as the principle of adequate historical thinking in criminology.
Artificial intelligence in medical practice
Authors: Fil Tatiana S.
Published: January 2024

With state support, artificial intelligence is being intensively introduced into the healthcare sector. This review provides general information about artificial intelligence and its place in the healthcare system. A part of the lecture is devoted to the Moscow experiment on the use of computer vision in real clinical practice and the experience of the Kirov region on the use of artificial intelligence in the medical examination of the population. The lecture will be interesting to doctors and students to expand their general understanding of artificial intelligence and the possibility of its application in practical healthcare.
The Magnitude–Frequency Distributions of Earthquakes in Aotearoa New Zealand and on Adjoining Subduction Zones, Using a New Integrated Earthquake Catalog
Authors: Rollins Chris , Gerstenberger Matthew C. , Rhoades David A. , Rastin Sepideh J. , Christophersen Annemarie , Thingbaijam Kiran Kumar S. , Van Dissen Russell J. , Graham Kenny , DiCaprio Chris , Fraser Jeff
Published: January 2024

Using a new integrated earthquake catalog for Aotearoa New Zealand (described in a companion article), we estimate the magnitude–frequency distributions (MFDs) of earthquakes in the greater New Zealand region and along the Hikurangi–Kermadec and Puysegur subduction zones. These are key inputs into the seismicity rate model (SRM) component of the 2022 New Zealand National Seismic Hazard Model. The MFDs are parameterized by a b-value (describing the relative rates of small and large earthquakes) with its epistemic uncertainty expressed by three logic tree branches (low, central, and high), and by the annual rate of M ≥ 5 earthquakes, here called the N-value, which has a separate value conditioned on each b-value branch. The N-value has its own epistemic uncertainty besides the dependence on the b-value, and this is also estimated here and propagated through the SRM by scaling all event rates up and down by a “low” and a “high” scalar value on either side of 1.0, called “N scaling.” Adapting an approach used previously in California, we estimate these MFD parameters in the onshore and near-shore region incorporating data back to 1843, balanced with the better data in the more recent part of the instrumental catalog. We estimate the MFD parameters on the Hikurangi–Kermadec and Puysegur subduction zones using a slightly simplified version of this approach and more recent data. We then use a globally-based method to estimate the potential earthquake rate uncertainty on the Hikurangi–Kermadec subduction zone and an SRM-specific moment-rate-related argument to construct an appropriately wide rate uncertainty for the Puysegur subduction zone.
Seismic Station Monitoring Using Deviation from the Gaussianity
Authors: Cuvier Arthur , Beucler Éric , Bonnin Mickaël , Garcia Raphaël F.
Published: January 2024

Degradation of the seismic signal quality sometimes occurs at permanent and temporary stations. Although the most likely cause is a high level of humidity, leading to corrosion of the connectors, environmental changes can also alter recording conditions in different frequency ranges and not necessarily for all three components in the same way. Assuming that the continuous seismic signal can be described by a normal distribution, we present a new approach to quantify the seismogram quality and to point out any time sample that deviates from this Gaussian assumption. We introduce the notion of background Gaussian signal (BGS) to characterize a set of samples that follows a normal distribution. The discrete function obtained by sorting the samples in ascending order of amplitudes is compared with a modified Probit function to retrieve the elements composing the BGS, and its statistical properties (mostly its standard deviation σG). As soon as there is any amplitude perturbation, σG deviates from the standard deviation of all samples composing the time window (σ). Hence, the parameter log(σσG) directly quantifies the alteration level. For a single day, a given frequency range and a given component, the median of all log(σσG) that can be computed using short-time windows, reflects the overall gaussianity of the continuous seismic signal. We demonstrate that it can be used to efficiently monitor the quality of seismic traces using this approach at four broadband permanent stations. We show that the daily log(σσG) is sensitive to both subtle changes on one or two components as well as the signal signature of a sensor’s degradation. Finally, we suggest that log(σσG) and other parameters that are computed from the BGS bring useful information for station monitoring in addition to existing methods.
Particular features of labor activity at the presence of inflammation of the uterine layers and placental membranes
Authors: Shatylovych K.L. , Markin L.B.
Published: January 2024

Research objectives: to analyze the association between the various abnormalities of the labor activity and inflammatory changes of the placental, fetal membranes, and uterine layers.Materials and methods. A prospective cohort study of 382 patients with singleton pregnancies at 28–42 weeks' gestation who underwent cesarean section for abnormal uterine contractions and other complications was conducted. The patients were divided into 3 observation groups: 168 women with hypotonic labor (HL), 70 women with hypertonic uterine dysfunction (HUD) and 144 women operated on for various indications (control group). The development of the inflammation of the decidua, myometrium, chorioamniotic membranes and umbilical cord in different types of labor activity abnormalities were studied. Statistical analyses included Mann-Whitney U test, Chi-squared test, and logistic regression. Results. In the control group on the eve of the labor the lower uterine segments' polymorphonuclear leukocytes and macrophages infiltration of mild grade were detected in 73.6 and 59.7% cases accordingly.The strength of the association of uterine layers, placental and fetal membranes inflammation with the HUD was: for the deciduitis – adjusted odds ratio (aOR): 2.6, 95% confidence interval (CI): 1.4–4.8; for the myometritis – aOR: 0.7, 95% CI: 0.3–2.4; for the histological chorioamnionitis (hCAM) – aOR: 4.5, 95% CI: 3.4–12.1; for the funisitis – aOR: 2.9, 95% CI: 1.3–10.6. The main clinical risk factors for hCAM, funisitis, and deciduitis in the HUD group, such as prematurity, nulliparity, group B streptococcus colonization, and duration of ruptured fetal membranes before the cesarean section, indicated the antenatal occurrence of inflammatory process. А decrease of the uterine contractility іn the HL group was associated with grade 2+ deciduitis (aOR: 1.4, 95% CI: 0.6–3.6) and grade II+ myometritis (aOR: 3.9, 95% CI: 1.3–14.7), but no association was found with stage II+ hCAM (aOR: 0.8, 95% CI: 0.3–4.9) and stage 2+ funisitis (aOR: 0.3, 95% CI: 0.6–2.7). Decidual and myometrial inflammation was significantly connected with nulliparity and intrapartum factors such as protracted active first stage of labor with oxytocin augmentation, advanced cervical dilation, and number of vaginal examinations. Inflammation of the myometrium was accompanied by the deciduitis in all cases.Conclusions. Mild inflammation of the decidua and myometrium of the lower segment of the uterus at term pregnancy is a physiological phenomenon that contributes to the initiation of labor. Inflammation of the chorioamniotic membranes and decidua against the background of intact myometrium plays a fundamental role in the occurrence of hypertensive uterine dysfunction, particularly in preterm birth. Marked myometrial inflammation that occurs in prolonged labor is an additional factor aggravating the hypotonic uterine activity.
Transgender in modern olympic sports: problems and ways of their solution
Authors: Shakhlina L.Y.-G. , Futornyi S.M. , Vladimirova N.I. , Maslova Рћ.V. , Kotko D.M. , Kolomiiets T.V. , Honcharuk N.L.
Published: January 2024

Background. In recent years, there have been active disputes and disagreements among international sports leaders, including representatives of the International Olympic Committee, about the possibility of including transgender athletes in the number of participants in the Olympic Games. Objective of the review: to analyze of the modern scientific literature data to substantiate the possibility of admitting transgender women to participate in the women’s competitions of the Olympic Games. Review results indicate that the number of transgender candidates for participation in sports of higher achievements may be caused by the increase in the transgender population in the world. Currently, there is no significant scientific evidence on the biological benefits that hinder the integrity of transgender women’s competition in women’s sports. There is also no evidence that transgender women who have opted for testosterone suppression (e.g. hormone therapy to confirm sex and/or surgical removal of the sex glands) retain an indefinite advantage over cisgender athletes. To be more precise, current evidence suggests that any biological benefits of transgender women in athletic performance do not fall outside the range that is observed among cisgender female athletes after testosterone suppression. However, experts disagree in the field of medicine about the morphofunctional differences of transgender female athletes and cisgender female athletes, society’s rejection of female athletes after transgender transition, the indecision of International Olympic Committee representatives in solving this problem in women’s sports relevant and extremely painful for healthy women, sportswomen, for the development of sports in general and women’s sports in particular.Our further research will be aimed at expanding the study of the conceptual foundations of combining two key areas of research - medico-biological and socio-cultural, with integration into the practice of sports as one of the actual issues of our time that require a theoretically justified and practically proven solution.
Probiotic combinations for women. Effectiveness and safety from the points of evidence-based medicine
Authors: Tsubanova N.A. , Dembitska E.S. , Galevich G.B.
Published: January 2024

To date, probiotic medicinal products have a significant number of clinical studies, which is the basis for the formation of an evidence base and their inclusion in modern treatment standards. However, ideas about the optimal composition of a probiotic preparation and effective dosage remain problematic issues in modern medicine. Choosing an effective probiotic in gynecological practice is a particularly difficult and important issue.Objective of the review: to analyze the available clinical studies aimed at identifying strains of beneficial bacteria, their dosage, possible combinations in order to choose the optimal composition of a probiotic agent for the treatment of dysbiosis, including vaginal.Materials and methods. Modern methods recommended for theoretical analytical research were used: method of analysis, method of synthesis, method of induction. An electronic search was conducted in bibliographic databases, including PubMed, CENTRAL, MEDLINE, Embase, and CINAHL. 58 scientific publications were analyzed. Inclusion criteria were the following keywords: probiotics, optimal dosage, optimal composition, dysbiosis.Results. The most important probiotic microorganisms for restoring health in women are Lactobacillus acidophilus, L. crispatus, L. jensenii, L. gasseri, L. rhamnosus. Each of these lactobacilli maintains the normal vaginal pH, produces hydrogen peroxide, suppresses growth and prevents the reproduction of obligate anaerobes and opportunistic microorganisms when interacting with the peroxidase of cervical mucus.The mechanism of action of the above-mentioned probiotic microorganisms was analyzed. It was established that the effective dose of each of the components should not be less than 1-2 billion colony forming units.Conclusions. The analysis of scientific publications in the bibliographic databases was sufficient to establish that the oral use of probiotics in the treatment of gynecological patients is effective. The optimal components of the probiotic agent, which are effective for the therapy of vaginal dysbiosis, are L. crispatus, L. gasseri, L. jensenii, L. rhamnosus, L. acidophilus.
Отражение травмирующего события в письменной речи
Authors: Дементьева А.Д. , Кортнева Ю.В.
Published: January 2024

Материалом исследования являются воспоминания о событиях, представленных в виде текста. Рассматриваются способы распознания в тексте признаков пережитой травмы. Указывается на возможность применения описанных критериев в онлайн-консультировании.
Оценка уровня развития морально-нравственных качеств личности учащихся подросткового возраста
Authors: Коноплева Е.А. , Колегова Т.Л.
Published: January 2024

В статье представлены результаты промежуточного исследования моральнонравственных качеств личности на выборке обучающихся 5-9 классов. Согласно теории нравственного развития Л. Колберга, морально-нравственная сфера личности формируется в период 13-18 лет. Приведенные данные позволяю предположить, что у современных детей уже в 10-12 лет сформированы базовые характеристики нравственности, а также, акцентировать внимание на роли воспитательной работы в образовательных организациях.
Técnicas de marketing político: del color a la elección
Authors: Cruz Luna Mariana , Garzón Pascagaza Edgar Javier
Published: January 2024

En el panorama de los bienes de consumo, una apuesta decisiva esta referida a los vínculos por medio de los cuales se pueda construir una imagen, ganar una posición, obtener un nivel de reconocimiento y estrategias para la promoción de un nombre, una marca o un ideal. En el caso del marketing político y el contexto de la representación política y su lugar en el entorno de las campañas y el electorado, el objetivo de este texto es identificar su naturaleza y sus fundamentos, sus elementos constitutivos y sus características, con la finalidad de comprender la relación que se construye entre la campaña política y las estrategias de comunicación de una campaña. Con un enfoque cualitativo, la metodología empleada es de tipo cuasiexperimental1, descriptiva y exploratoria, al plantear y desarrollar teorías, aplicando su contenido hacia algunos objetos-sujetos de la realidad. Entre los hallazgos, corresponde enfatizar la relación entre el marketing político y la teoría del color, y las dificultades de encontrar un sentido unificado para el uso de los colores en las campañas electorales y, para el caso, el uso del color azul. Sin embargo, queda abierta la inquietud de comprender el porqué de su preferencia y de su influencia ganadora.
EFFECT OF ANTIPHOSPHOLIPID IN IRAQI WOMEN UNDERGOING ICSI TECHNIQUE
Authors:   Faculty of Science, University of Kufa, Najaf City, Iraq, AL-Sallami Alaauldeen S.M. , Al-Shimerty Dhirgam F. Hassan. ,   College of Pharmacy, University of Kufa, Najaf City, Iraq
Published: January 2024

This study was conducted on 84 Iraqi women samples under the ICSI program. The sample was divided into two parts: intravenous blood section for WBC measurement and serum section for antiphospholipid (IgG & IgM) measurement, while hCG was used to indicate the success of ICSI and the presence or absence of pregnancy. The results showed a significant difference (p < 0.05) between the pregnancy failure group and the abortion group compared with the control group (pregnancy continuation) about the level of Antiphospholipid (IgG-IgM) and WBC. The current study found a positive relationship between the level of Antiphospholipid (IgG-IgM) and WBC of these two factors, concluded that both criteria may indicate one for the other in women who suffer from miscarriage and pregnancy failure after ICSI.
DETECTION AND PATHOGENICITY LEVEL SCREENING OF HEMOLYTIC BACTERIA ISOLATED FROM UNPACKED CHICKEN NUGGET
Authors:   Diploma of Health Analyst Study Program, Faculty of Nursing and Health Sciences, Universitas Muhammadiyah Semarang, Alfiyani Ika , Mukaromah Ana Hidayati ,   Magister of Clinical Laboratory Science, Postgraduate Program, Uiversitas Muhammadiyah Semarang, Afriansyah Muhammad Ardi ,   Diploma of Health Analyst Study Program, Faculty of Nursing and Health Sciences, Universitas Muhammadiyah Semarang, Ethica Stalis Norma ,   Magister of Clinical Laboratory Science, Postgraduate Program, Uiversitas Muhammadiyah Semarang
Published: January 2024

Food poisoning is a severe threat that can lead to death. According to the WHO, cases of food poisoning have been on the rise in recent years. Pathogenic bacteria are responsible for food poisoning, often originating from contaminated food. Chicken nuggets, a popular ready-to-eat food, are susceptible to bacterial growth due to the risk of microbial contamination during storage. This study aims to assess the pathogenicity levels of bacteria in chicken nuggets when stored at room temperature for seven days. Samples from chicken nuggets left at room temperature were diluted and cultured on Nutrient Agar (NA) media. Subsequently, bacterial pathogenicity screening was conducted using MacConkey Agar (MC), Blood Agar Plate (BAP), and Chocolate Agar Plate (CAP). The results revealed six bacterial isolates labeled FMCN-1 to FMCN-6 (FMCN denoting Fatmawati Market chicken nugget). Most isolates exhibited a moderate level of pathogenicity (FMCN-2, FMCN-3, FMCN-4, FMCN-5, and FMCN-6), with only one isolate demonstrating low pathogenicity (FMCN-1). In conclusion, storing chicken nuggets at room temperature for seven days can lead to bacterial contamination with mostly moderate pathogenicity. Further molecular analysis is required to identify the potentially harmful bacteria.
Avaliação do desempenho térmico de ambiente escolar padronizado, em contexto climático brasileiro, por meio de simulação termoenergética
Authors: Lopes Adriano Felipe Oliveira , Silva Caio Frederico e , Amorim Cláudia Naves David , Batista Juliana Oliveira
Published: January 2024

Esse artigo propõe avaliar, por meio de simulação termoenergética, o desempenho térmico por meio do índice de conforto térmico adaptativo do projeto padrão de escola desenvolvido pelo Fundação Nacional de Desenvolvimento da Educação (FNDE) em busca de melhor adequá-lo a diferentes contextos climáticos brasileiros. O método empregado é divido em três etapas e consiste no desenvolvimento de modelo termoenergético, diagnóstico do percentual de horas ocupadas em conforto (POC) e análise estatística para verificação da sensibilidade de variáveis de projeto sobre o POC em climas distintos. Para o desenvolvimento do modelo utilizou-se o software Designbuilder (versão 6.1.3), interface gráfica do algoritmo de cálculo Energyplus (versão 8.9.0), considerando sua implantação em seis cidades: Brasília (DF), Curitiba (PR), Cuiabá (MT), Natal (RN), Porto Alegre (RS) e Rio de Janeiro (RJ). Adotou-se a variável temperatura neutra (Tn), em conformidade com as normas ASHRAE 55 e NBR 16401, para delimitação do intervalo de conforto para o cálculo do POC. Por último, verificou-se a influência de nove diferentes variáveis de projeto a partir da análise dos coeficientes de regressão padronizado (SRC), determinação (R²) e probabilidade (p-value). Os resultados indicaram limitações à utilização do mesmo projeto padrão sobretudo para os climas de Cuiabá e Natal, onde o POC apresentou valores inferiores a 30%. Além disso, foi possível observar que as variáveis de maior influência estão associadas à ocupação e transmitância de paredes e coberturas tornando possível identificar padrões de uso e recomendar soluções para as envoltórias mais adequadas a cada contexto climático por meio de diagrama sintético.