bluuebunny/crossref_metadata_2025 huggingface dataset:
THE MAGICAL POTENTIAL OF STONES USED FOR CYLINDER SEALS: NEW MANUSCRIPTS OF THE TEXT KNOWN FROM BAM 194 VIII’ 9’–14’
Authors: Simkó Krisztián
Published: January 2016

Besides their significance in administrative procedures, cylinder seals also played an important role as amulets in ancient Mesopotamia. There are many references to them being used in medical and magical procedures, which sometimes determine their features of magical potential. Thus not only the imagery and inscription of cylinder seals but also the raw material of which they were made contributed to their medico-magical usage (cf. Collon 1987: 119; 1997: 19–20). This paper deals with the last-mentioned feature of cylinder seals, that is their raw material, which is treated in a short series known from BAM 194 viii’ 9’–14’, as well as from another three tablets published here for the first time.
LANDSCAPE AND SETTLEMENT IN THE EASTERN UPPER IRAQI TIGRIS AND NAVKUR PLAINS: THE LAND OF NINEVEH ARCHAEOLOGICAL PROJECT, SEASONS 2012–2013
Authors: Bonacossi Daniele Morandi , Iamoni Marco
Published: January 2016

This paper presents a preliminary report on the first two seasons of work by The Land of Nineveh Archaeological Project (LoNAP) of Udine University that aims to understand the formation and transformation of the cultural and natural landscape of northern Mesopotamia, (embracing large parts of the governorates of Ninawa and Dohuk) from the Palaeolithic to the Islamic period. Its purpose is to comprehend patterns of settlement, land use and management, based on a regional archaeological surface survey and excavation. These objectives are closely tied to the geoarcheological and bioarchaeological reconstruction of the ancient natural environment and its evolution as a result of global climatic fluctuations and human impact.
MORE THOUGHTS ON THE BALAWAT GATES OF SHALMANESER III: THE ARRANGEMENT OF THE BANDS
Authors: Curtis John , Tallis Nigel
Published: January 2016

This article seeks to demonstrate that the correct arrangement of the bronze bands on the Shalmaneser III gates from Balawat can be established by comparing the position of the nail holes on the ends of the bands with those on the edging strips that were fixed to the edges of the doors and partly overlap the ends of the bands. This new approach confirms the order previously proposed by Curtis and Tallis for the bands on the left-hand gate, but a new arrangement is suggested for the four lower bands on the right-hand gate.
Trinity, generality, and dominance
Authors: BABER H. E.
Published: January 2016

I defend a relative identity solution to the identity puzzle posed by the doctrine of the Trinity. It has been argued that relative identity theories which admit absolute identity, such as the account proposed here, do not succeed in saving the doctrine of the Trinity from logical incoherence. I show that this argument fails. Relative identity theories that admit absolute identity are logically conservative, metaphysically innocent, and unproblematic. And, given the account I propose we can, without incurring any logical or metaphysical costs, hold that Father, Son, and Holy Spirit are the same being but not the same trinitarian person.
MINDING THEIR OWN BUSINESS: MARRIED WOMEN AND CREDIT IN EARLY EIGHTEENTH-CENTURY LONDON
Authors: Shepard Alexandra
Published: January 2016

Taking a micro-historical approach, this paper explores the business activities of Elizabeth Carter and Elizabeth Hatchett, two married women who operated together as pawnbrokers in London in the early decades of the eighteenth century. Based on a protracted inheritance dispute through which their extensive dealings come to light, the discussion assesses married women's lending and investment strategies in a burgeoning metropolitan economy; the networks through which women lenders operated; and the extent to which wives could sidestep the legal conventions of ‘coverture’ which restricted their ownership of moveable property. It is argued that the moneylending and asset management activities of women like Carter and Hatchett were an important part of married women's work that did not simply consolidate neighbourhood ties but that placed them at the heart of the early modern economy.
DISPERSIVE ORDERING FOR THE MULTIVARIATE NORMAL DISTRIBUTION
Authors: Leng Xuan , Zhuang Jinsen , Hu Taizhong
Published: January 2016

Let (X1, …, Xn) be a multivariate normal random vector with any mean vector, variances equal to 1 and covariances equal and positive. Turner and Whitehead [9] established that the largest order statistic max{X1, …, Xn} is less than the standard normal random variable in the dispersive order. In this paper, we give a new and straightforward proof for this result. Several possible extensions of this result are also discussed.
Decomposition of Multiple Packings with Subquadratic Union Complexity
Authors: PACH JÁNOS , WALCZAK BARTOSZ
Published: January 2016

Suppose k is a positive integer and ${\cal X}$ is a k-fold packing of the plane by infinitely many arc-connected compact sets, which means that every point of the plane belongs to at most k sets. Suppose there is a function f(n) = o(n2) with the property that any n members of ${\cal X}$ determine at most f(n) holes, which means that the complement of their union has at most f(n) bounded connected components. We use tools from extremal graph theory and the topological Helly theorem to prove that ${\cal X}$ can be decomposed into at most p (1-fold) packings, where p is a constant depending only on k and f.
Terrorism in Turkey
Authors: Rodoplu Ulkumen , Arnold Jeffrey , Ersoy Gurkan
Published: January 2016

Over the past two decades, terrorism has exacted an enormous toll on the
Republic of Turkey, a secular democracy with a 99.8% Muslim population. From
1984 to 2000, an estimated 30,000 to 35,000 Turkish citizens were killed by
a nearly continuous stream of terrorism-related events. During this period,
the Partiya Karekeren Kurdistan (PKK), a Kurdish separatist group (re-named
KADEK in 2002), was responsible for the vast majority of terrorism-related
events (and casualties), which disproportionately affected the eastern and
southeastern regions of Turkey, in which the PKK has focused its activities.
Most terrorist attacks over the past two decades have been bombings or
shootings that produced <10 casualties per event. From 1984 to 2003, 15
terrorist attacks produced ≥30 casualties (eight shootings, five bombings,
and two arsons). The maximum number of casualties produced by any of these
events was 93 in the Hotel Madimak arson attack by the Tu r kish Islamic
Movement in 1993.

This pattern suggests that terrorist attacks in Turkey rarely required
more than local systems of emergency medical response, except in rural areas
where Emergency Medical Services (EMS) are routinely provided by regional
military resources. The last decade has seen the development of several key
systems of local emergency response in Turkey, including the establishment
of the medical specialty of Emergency Medicine, the establishment of
training programs for EMS providers, the spread of a generic, Turkish
hospital emergency plan based on the Hospital Emergency Incident Command
System, and the spread of advanced training in trauma care modeled after
Advanced Trauma Life Support.
Government Procurement in the WTO: A Case for Greater Integration
Authors: DAWAR KAMALA
Published: January 2016

This article assesses the regulation of government procurement in the WTO, specifically under the WTO Government Procurement Agreement (WTO GPA), the General Agreement on Tariffs in Trade (GATT), the General Agreement on Trade in Services (GATS), and the Agreement on Subsidies and Countervailing Measures (ASCM). It compares these findings from leading regional trade agreements (RTAs) with government procurement regulation, most notably the North American Free Trade Area (NAFTA) and the Treaty on the Functioning of the European Union (TFEU).
Using Sounds from the Ocean to Measure Winds in the Stratosphere
Authors: Arrowsmith Marie , Arrowsmith Stephen , Marcillo Omar
Published: January 2016

Stratospheric winds deflect acoustic waves from the oceans. With the right data and the math to analyze them, these waves tell us about the weather aloft.
BPTF is required for c-MYC transcriptional activity and in vivo tumorigenesis
Authors: Richart Laia , Carrillo-de Santa Pau Enrique , Río-Machín Ana , de Andrés Mónica P. , Cigudosa Juan C. , Lobo Víctor J. Sánchez-Arévalo , Real Francisco X.
Published: January 2016

c-MYC oncogene is deregulated in most human tumours. Histone marks associated with transcriptionally active genes define high-affinity c-MYC targets. The mechanisms involved in their recognition by c-MYC are unknown. Here we report that c-MYC interacts with BPTF, a core subunit of the NURF chromatin-remodelling complex. BPTF is required for the activation of the full c-MYC transcriptional programme in fibroblasts. BPTF knockdown leads to decreased c-MYC recruitment to DNA and changes in chromatin accessibility. In Bptf-null MEFs, BPTF is necessary for c-MYC-driven proliferation, G1–S progression and replication stress, but not for c-MYC-driven apoptosis. Bioinformatics analyses unveil that BPTF levels correlate positively with c-MYC-driven transcriptional signatures. In vivo, Bptf inactivation in pre-neoplastic pancreatic acinar cells significantly delays tumour development and extends survival. Our findings uncover BPTF as a crucial c-MYC co-factor required for its biological activity and suggest that the BPTF-c-MYC axis is a potential therapeutic target in cancer.
Surface-enabled propulsion and control of colloidal microwheels
Authors: Tasci T. O. , Herson P. S. , Neeves K. B. , Marr D. W. M.
Published: January 2016

Propulsion at the microscale requires unique strategies such as the undulating or rotating filaments that microorganisms have evolved to swim. These features however can be difficult to artificially replicate and control, limiting the ability to actuate and direct engineered microdevices to targeted locations within practical timeframes. An alternative propulsion strategy to swimming is rolling. Here we report that low-strength magnetic fields can reversibly assemble wheel-shaped devices in situ from individual colloidal building blocks and also drive, rotate and direct them along surfaces at velocities faster than most other microscale propulsion schemes. By varying spin frequency and angle relative to the surface, we demonstrate that microwheels can be directed rapidly and precisely along user-defined paths. Such in situ assembly of readily modified colloidal devices capable of targeted movements provides a practical transport and delivery tool for microscale applications, especially those in complex or tortuous geometries.
Proteomic maps of breast cancer subtypes
Authors: Tyanova Stefka , Albrechtsen Reidar , Kronqvist Pauliina , Cox Juergen , Mann Matthias , Geiger Tamar
Published: January 2016

Systems-wide profiling of breast cancer has almost always entailed RNA and DNA analysis by microarray and sequencing techniques. Marked developments in proteomic technologies now enable very deep profiling of clinical samples, with high identification and quantification accuracy. We analysed 40 oestrogen receptor positive (luminal), Her2 positive and triple negative breast tumours and reached a quantitative depth of >10,000 proteins. These proteomic profiles identified functional differences between breast cancer subtypes, related to energy metabolism, cell growth, mRNA translation and cell–cell communication. Furthermore, we derived a signature of 19 proteins, which differ between the breast cancer subtypes, through support vector machine (SVM)-based classification and feature selection. Remarkably, only three proteins of the signature were associated with gene copy number variations and eleven were also reflected on the mRNA level. These breast cancer features revealed by our work provide novel insights that may ultimately translate to development of subtype-specific therapeutics.
A liquid-crystalline hexagonal columnar phase in highly-dilute suspensions of imogolite nanotubes
Authors: Paineau Erwan , Krapf Marie-Eve M. , Amara Mohamed-Salah , Matskova Natalia V. , Dozov Ivan , Rouzière Stéphan , Thill Antoine , Launois Pascale , Davidson Patrick
Published: January 2016

Liquid crystals have found wide applications in many fields ranging from detergents to information displays and they are also increasingly being used in the ‘bottom-up’ self-assembly approach of material nano-structuration. Moreover, liquid-crystalline organizations are frequently observed by biologists. Here we show that one of the four major lyotropic liquid-crystal phases, the columnar one, is much more stable on dilution than reported so far in literature. Indeed, aqueous suspensions of imogolite nanotubes, at low ionic strength, display the columnar liquid-crystal phase at volume fractions as low as ∼0.2%. Consequently, due to its low visco-elasticity, this columnar phase is easily aligned in an alternating current electric field, in contrast with usual columnar liquid-crystal phases. These findings should have important implications for the statistical physics of the suspensions of charged rods and could also be exploited in materials science to prepare ordered nanocomposites and in biophysics to better understand solutions of rod-like biopolymers.
MYB96 shapes the circadian gating of ABA signaling in Arabidopsis
Authors: Lee Hong Gil , Mas Paloma , Seo Pil Joon
Published: January 2016

Circadian clocks regulate the rhythms of biological activities with a period of approximately 24-hours and synchronize plant metabolism and physiology with the environmental cycles. The clock also gates responses to environmental stresses to maximize fitness advantages. Here we report that the MYB96 transcription factor is connected with the clock oscillator to shape the circadian gating of abscisic acid (ABA) responses. MYB96 directly binds to theTIMING OF CAB EXPRESSION 1(TOC1) promoter to positively regulate its expression. The use ofmyb96mutant plants shows that this regulation is essential for the gated induction ofTOC1by ABA. In turn,MYB96induction by ABA is also altered intoc1-3mutant plants. The increased tolerance to drought ofMYB96over-expressing plants is decreased in thetoc1-3mutant background, suggesting that MYB96 and TOC1 intersect the circadian clock and ABA signaling. The MYB96-TOC1 function might be also regulated by the clock component CIRCADIAN CLOCK-ASSOCIATED 1 (CCA1), which binds to theMYB96promoter and alters its circadian expression. Thus, a complex circuitry of CCA1-MYB96-TOC1 regulatory interactions provides the mechanistic basis underlying the connection between circadian and stress signaling to optimize plant fitness to ambient stresses.
Talaromyces neofusisporus and T. qii, two new species of section Talaromyces isolated from plant leaves in Tibet, China
Authors: Wang Qi-Ming , Zhang Yong-Hong , Wang Bo , Wang Long
Published: January 2016

Two new species isolated from plant leaves belonging to Talaromyces section Talaromyces are reported, namely T. neofusisporus (ex-type AS3.15415 T = CBS 139516 T) and T. qii (ex-type AS3.15414 T = CBS 139515 T). Morphologically, T. neofusisporus is featured by forming synnemata on CYA and YES, bearing appressed biverticillate penicilli and smooth-walled fusiform conidia about 3.5–4.5 × 2–2.5 μm; and T. qii is characterized by velutinous colony texture, yellowish green conidia, yellow mycelium and ovoid to subglobose echinulate conidia measuring 3–3.5 μm. Phylogenetically, T. neofusisporus is such a unique species that no close relatives are found according to CaM, BenA and ITS1-5.8S-ITS2 as well as the combined three-gene sequences; and T. qii is related to T. thailandensis according to CaM, BenA and the combined sequence matrices, whereas ITS1-5.8S-ITS2 sequences do not support the close relationship between T. qii and T. thailandensis.
Off like a shot: scaling of ballistic tongue projection reveals extremely high performance in small chameleons
Authors: Anderson Christopher V.
Published: January 2016

Stretching elastic tissues and using their recoil to power movement allows organisms to release energy more rapidly than by muscle contraction directly, thus amplifying power output. Chameleons employ such a mechanism to ballistically project their tongue up to two body lengths, achieving power outputs nearly three times greater than those possibleviamuscle contraction. Additionally, small organisms tend to be capable of greater performance than larger species performing similar movements. To test the hypothesis that small chameleon species outperform larger species during ballistic tongue projection, performance was examined during feeding among 20 chameleon species in nine genera. This revealed that small species project their tongues proportionately further than large species, achieving projection distances of 2.5 body lengths. Furthermore, feedings with peak accelerations of 2,590 m s−2, or 264 gand peak power output values of 14,040 W kg−1are reported. These values represent the highest accelerations and power outputs reported for any amniote movement, highlighting the previously underestimated performance capability of the family. These findings show that examining movements in smaller animals may expose movements harbouring cryptic power amplification mechanisms and illustrate how varying metabolic demands may help drive morphological evolution.
3D macroporous electrode and high-performance in lithium-ion batteries using SnO2 coated on Cu foam
Authors: Um Ji Hyun , Choi Myounggeun , Park Hyeji , Cho Yong-Hun , Dunand David C. , Choe Heeman , Sung Yung-Eun
Published: January 2016

A three-dimensional porous architecture makes an attractive electrode structure, as it has an intrinsic structural integrity and an ability to buffer stress in lithium-ion batteries caused by the large volume changes in high-capacity anode materials during cycling. Here we report the first demonstration of a SnO2-coated macroporous Cu foam anode by employing a facile and scalable combination of directional freeze-casting and sol-gel coating processes. The three-dimensional interconnected anode is composed of aligned microscale channels separated by SnO2-coated Cu walls and much finer micrometer pores, adding to surface area and providing space for volume expansion of SnO2 coating layer. With this anode, we achieve a high reversible capacity of 750 mAh g−1 at current rate of 0.5 C after 50 cycles and an excellent rate capability of 590 mAh g−1 at 2 C, which is close to the best performance of Sn-based nanoscale material so far.
Structural characterization of eRF1 mutants indicate a complex mechanism of stop codon recognition
Authors: Pillay Shubhadra , Li Yan , Wong Leo E , Pervushin Konstantin
Published: January 2016

Eukarya translation termination requires the stop codon recognizing protein eRF1. In contrast to the multiple proteins required for translation termination in Bacteria, eRF1 retains the ability to recognize all three of the stop codons. The details of the mechanism that eRF1 uses to recognize stop codons has remained elusive. This study describes the structural effects of mutations in the eRF1 N-domain that have previously been shown to alter stop codon recognition specificity. Here, we propose a model of eRF1 binding to the pre-translation termination ribosomal complex that is based in part on our solution NMR structures of the wild-type and mutant eRF1 N-domains. Since structural perturbations induced by these mutations were spread throughout the protein structure, residual dipolar coupling (RDC) data were recorded to establish the long-range effects of the specific mutations, E55Q, Y125F, Q122FM(Y)F126. RDCs were recorded on 15N-labeled eRF1 N-domain weakly aligned in either 5% w/v n-octyl-penta (ethylene glycol)/octanol (C8E5) or the filamentous phage Pf1. These data indicate that the mutations alter the conformation and dynamics of the GTS loop that is distant from the mutation sites. We propose that the GTS loop forms a switch that is key for the multiple codon recognition capability of eRF1.
Altered Phenylpropanoid Metabolism in the Maize Lc-Expressed Sweet Potato (Ipomoea batatas) Affects Storage Root Development
Authors: Wang Hongxia , Yang Jun , Zhang Min , Fan Weijuan , Firon Nurit , Pattanaik Sitakanta , Yuan Ling , Zhang Peng
Published: January 2016

There is no direct evidence of the effect of lignin metabolism on early storage root development in sweet potato. In this study, we found that heterologous expression of the maize leaf color (Lc) gene in sweet potato increased anthocyanin pigment accumulation in the whole plant and resulted in reduced size with an increased length/width ratio, low yield and less starch content in the early storage roots. RT-PCR analysis revealed dramatic up-regulation of the genes involved in the lignin biosynthesis pathway in developing storage roots, leading to greater lignin content in theLctransgenic lines, compared to the wild type. This was also evidenced by the enhanced lignification of vascular cells in the early storage roots. Furthermore, increased expression of the β-amylase gene in leaves and storage roots also accelerated starch degradation and increased the sugar use efficiency, providing more energy and carbohydrate sources for lignin biosynthesis in theLctransgenic sweet potato. Lesser starch accumulation was observed in the developing storage roots at the initiation stage in the Lc plants. Our study provides experimental evidence of the basic carbohydrate metabolism underlying the development of storage roots, which is the transformation of lignin biosynthesis to starch biosynthesis.
Characterization of vegetative inflorescence (mc-vin) mutant provides new insight into the role of MACROCALYX in regulating inflorescence development of tomato
Authors: Yuste-Lisbona Fernando J. , Quinet Muriel , Fernández-Lozano Antonia , Pineda Benito , Moreno Vicente , Angosto Trinidad , Lozano Rafael
Published: January 2016

Inflorescence development is a key factor of plant productivity, as it determines flower number. Therefore, understanding the mechanisms that regulate inflorescence architecture is critical for reproductive success and crop yield. In this study, a new mutant, vegetative inflorescence (mc-vin), was isolated from the screening of a tomato (Solanum lycopersicum L.) T-DNA mutant collection. The mc-vin mutant developed inflorescences that reverted to vegetative growth after forming two to three flowers, indicating that the mutated gene is essential for the maintenance of inflorescence meristem identity. The T-DNA was inserted into the promoter region of the MACROCALYX (MC) gene; this result together with complementation test and expression analyses proved that mc-vin is a new knock-out allele of MC. Double combinations between mc-vin and jointless (j) and single flower truss (sft) inflorescence mutants showed that MC has pleiotropic effects on the reproductive phase and that it interacts with SFT and J to control floral transition and inflorescence fate in tomato. In addition, MC expression was mis-regulated in j and sft mutants whereas J and SFT were significantly up-regulated in the mc-vin mutant. Together, these results provide new evidences about MC function as part of the genetic network regulating the development of tomato inflorescence meristem.
Mineral and organic growing media have distinct community structure, stability and functionality in soilless culture systems
Authors: Grunert Oliver , Hernandez-Sanabria Emma , Vilchez-Vargas Ramiro , Jauregui Ruy , Pieper Dietmar H. , Perneel Maaike , Van Labeke Marie-Christine , Reheul Dirk , Boon Nico
Published: January 2016

The choice of soilless growing medium for plant nutrition, growth and support is crucial for improving the eco-sustainability of the production in horticultural systems. As our current understanding of the functional microbial communities inhabiting this ecosystem is still limited, we examined the microbial community development of the two most important growing media (organic and mineral) used in open soilless horticultural systems. We aimed to identify factors that influence community composition over time and to compare the distribution of individual taxa across growing media and their potential functionality. High throughput sequencing analysis revealed a distinctive and stable microbial community in the organic growing medium. Humidity, pH, nitrate-N, ammonium-N and conductivity were uncovered as the main factors associated with the resident bacterial communities. Ammonium-N was correlated with Rhizobiaceae abundance, while potential competitive interactions among both Methylophilaceae and Actinobacteridae with Rhizobiaceae were suggested. Our results revealed that soilless growing media are unique niches for diverse bacterial communities with temporal functional stability, which may possibly impact the resistance to external forces. These differences in communities can be used to develop strategies to move towards a sustainable horticulture with increased productivity and quality.
Cryptic effects of habitat declines: coral-associated fishes avoid coral-seaweed interactions due to visual and chemical cues
Authors: Brooker Rohan M. , Brandl Simon J. , Dixson Danielle L.
Published: January 2016

Seaweed-dominated coral reefs are becoming increasingly common as environmental conditions shift away from those required by corals and toward those ideal for rampant seaweed growth. How coral-associated organisms respond to seaweed will not only impact their fate following environmental change but potentially also the trajectories of the coral communities on which they rely. However, behavioral responses by coral-associated organisms to seaweeds are poorly understood. This study examined interactions between a guild of obligate and opportunistic coral-feeding butterflyfishes (Chaetodontidae) and scleractinian corals to determine whether fishes continue to interact with corals in contact with seaweed or if they are avoided. Under natural conditions, all species interacted almost exclusively with seaweed-free corals. In a controlled patch reef experiment, fishes avoided corals in physical contact with seaweed, irrespective of dietary preferences. When visual seaweed cues were removed, butterflyfish continued to avoid corals that had been in contact with the allelopathic Galaxaura filamentosa, suggesting that chemical cues produced by coral-seaweed interactions are repellent. These findings suggest that, due to deleterious visual and chemical cues produced by coral-seaweed interactions, coral-associated organisms may struggle to locate resources as seaweed-free corals decline in abundance.
Potent Antibacterial Nanoparticles against Biofilm and Intracellular Bacteria
Authors: Mu Haibo , Tang Jiangjiang , Liu Qianjin , Sun Chunli , Wang Tingting , Duan Jinyou
Published: January 2016

The chronic infections related to biofilm and intracellular bacteria are always hard to be cured because of their inherent resistance to both antimicrobial agents and host defenses. Herein we develop a facile approach to overcome the above conundrum through phosphatidylcholine-decorated Au nanoparticles loaded with gentamicin (GPA NPs). The nanoparticles were characterized by scanning electron microscopy (SEM), dynamic light scattering (DLS) and ultraviolet−visible (UV−vis) absorption spectra which demonstrated that GPA NPs with a diameter of approximately 180 nm were uniform. The loading manner and release behaviors were also investigated. The generated GPA NPs maintained their antibiotic activities against planktonic bacteria, but more effective to damage established biofilms and inhibited biofilm formation of pathogens including Gram-positive and Gram-negative bacteria. In addition, GPA NPs were observed to be nontoxic to RAW 264.7 cells and readily engulfed by the macrophages, which facilitated the killing of intracellular bacteria in infected macrophages. These results suggested GPA NPs might be a promising antibacterial agent for effective treatment of chronic infections due to microbial biofilm and intracellular bacteria.
Supramolecular polymerization of a prebiotic nucleoside provides insights into the creation of sequence-controlled polymers
Authors: Wang Jun , Bonnesen Peter V. , Rangel E. , Vallejo E. , Sanchez-Castillo Ariadna , James Cleaves II H. , Baddorf Arthur P. , Sumpter Bobby G. , Pan Minghu , Maksymovych Petro , Fuentes-Cabrera Miguel
Published: January 2016

Self-assembly of a nucleoside on Au(111) was studied to ascertain whether polymerization on well-defined substrates constitutes a promising approach for making sequence-controlled polymers. Scanning tunneling microscopy and density functional theory were used to investigate the self-assembly on Au(111) of (RS)-N9-(2,3-dihydroxypropyl)adenine (DHPA), a plausibly prebiotic nucleoside analog of adenosine. It is found that DHPA molecules self-assemble into a hydrogen-bonded polymer that grows almost exclusively along the herringbone reconstruction pattern, has a two component sequence that is repeated over hundreds of nanometers and is erasable with electron-induced excitation. Although the sequence is simple, more complicated ones are envisioned if two or more nucleoside types are combined. Because polymerization occurs on a substrate in a dry environment, the success of each combination can be gauged with high-resolution imaging and accurate modeling techniques. These characteristics make nucleoside self-assembly on a substrate an attractive approach for designing sequence-controlled polymers. Further, by choosing plausibly prebiotic nucleosides, insights may be provided into how nature created the first sequence-controlled polymers capable of storing information. Such insights, in turn, can inspire new ways of synthesizing sequence-controlled polymers.
Connectomic markers of disease expression, genetic risk and resilience in bipolar disorder
Authors: Dima D , Roberts R E , Frangou S
Published: January 2016

Bipolar disorder (BD) is characterized by emotional dysregulation and cognitive deficits associated with abnormal connectivity between subcortical—primarily emotional processing regions—and prefrontal regulatory areas. Given the significant contribution of genetic factors to BD, studies in unaffected first-degree relatives can identify neural mechanisms of genetic risk but also resilience, thus paving the way for preventive interventions. Dynamic causal modeling (DCM) and random-effects Bayesian model selection were used to define and assess connectomic phenotypes linked to facial affect processing and working memory in a demographically matched sample of first-degree relatives carefully selected for resilience (n=25), euthymic patients with BD (n=41) and unrelated healthy controls (n=46). During facial affect processing, patients and relatives showed similarly increased frontolimbic connectivity; resilient relatives, however, evidenced additional adaptive hyperconnectivity within the ventral visual stream. During working memory processing, patients displayed widespread hypoconnectivity within the corresponding network. In contrast, working memory network connectivity in resilient relatives was comparable to that of controls. Our results indicate that frontolimbic dysfunction during affect processing could represent a marker of genetic risk to BD, and diffuse hypoconnectivity within the working memory network a marker of disease expression. The association of hyperconnectivity within the affect-processing network with resilience to BD suggests adaptive plasticity that allows for compensatory changes and encourages further investigation of this phenotype in genetic and early intervention studies.
Amplification-free in situ KRAS point mutation detection at 60 copies per mL in urine in a background of 1000-fold wild type
Authors: Kirimli Ceyhun E. , Shih Wei-Heng , Shih Wan Y.
Published: January 2016

We have examined thein situdetection of a single-nucleotideKRASmutation in urine using a (Pb(Mg1/3Nb2/3)O3)0.65(PbTiO3)0.35(PMN-PT) piezoelectric plate sensor (PEPS) coated with a 17-nucleotide (nt) locked nucleic acid (LNA) probe DNA complementary to theKRASmutation.
Ion mobility mass spectrometry of peptide, protein, and protein complex ions using a radio-frequency confining drift cell
Authors: Allen Samuel J. , Giles Kevin , Gilbert Tony , Bush Matthew F.
Published: January 2016

A new drift cell was used to measure collision cross sections and characterize the origins of ion mobility peak broadening for biological molecules and assemblies.
A universal strategy for visual chiral recognition of α-amino acids with l-tartaric acid-capped gold nanoparticles as colorimetric probes
Authors: Song Guoxin , Zhou Fulin , Xu Chunli , Li Baoxin
Published: January 2016

All of 19 right-handed α-amino acids can induce a red-to-blue color change of l-tartaric acid-capped AuNP solution, whereas all of the left-handed amino acids (except cysteine) cannot.
Development of an electrochemical nanosensor for the determination of gallic acid in food
Authors: Ghaani Masoud , Nasirizadeh Navid , Yasini Ardakani Seyed Ali , Mehrjardi Farzaneh Zare , Scampicchio Matteo , Farris Stefano
Published: January 2016

In the present work, a silver nanoparticle/delphinidin modified glassy carbon electrode (AgNP/Delph/GCE) was fabricated as a highly sensitive electrochemical sensor for gallic acid (GA) determination.
Comparison and data fusion of an electronic nose and near-infrared reflectance spectroscopy for the discrimination of ginsengs
Authors: Miao Jiacheng , Luo Zhiyuan , Wang You , Li Guang
Published: January 2016

This paper reports a hybrid system consisting of a homemade electronic nose system (E-nose) with a sensor array of 16 metal-oxide sensors and near-infrared reflectance spectroscopy (NIRS) system for discriminating different kinds of ginsengs.
DNA aptamer release from the DNA–SWNT hybrid by protein recognition
Authors: Yoo Chang-Hyuk , Jung Seungwon , Bae Jaehyun , Kim Gunn , Ihm Jisoon , Lee Junghoon
Published: January 2016

The hybrid reacts with the target protein specifically and after that the aptamer–thrombin complex is detached from the SWNT.
Encapsulation of alkyldiammonium ions within two different cavities of twisted cucurbit[14]uril
Authors: Li Qing , Qiu Sheng-Chao , Chen Kai , Zhang Ying , Wang Ruibing , Huang Ying , Tao Zhu , Zhu Qian-Jiang , Liu Jing-Xin
Published: January 2016

This study shows that the twisted cucurbit[14]uril features two different cavities, which can encapsulate two or even three guest molecules with suitable shape and size, forming a special inclusion complex.
A new class of Ru(ii) polyazine agents with potential for photodynamic therapy
Authors: Padilla Roberto , Rodriguez-Corrales José A. , Donohoe Lauren E. , Winkel Brenda S. J. , Brewer Karen J.
Published: January 2016

Appending anthracene units to [(bpy)2Ru(dpp)]2+ results in Ru(ii) agents that exhibit dynamic photoreactivity towards DNA and protein.
Sustainable metal alkynyl chemistry: 3d metals and polyaza macrocyclic ligands
Authors: Ren Tong
Published: January 2016

This article describes the recent development of sustainable metal-alkynyl chemistry based on the combination of 3d metals and polyaza macrocycles.
Highly diastereoselective approach to methylenecyclopropanes via boron-homologation/allylboration sequences
Authors: Baumann A. N. , Music A. , Karaghiosoff K. , Didier D.
Published: January 2016

Unprecedented one-pot highly diastereoselective synthesis of methylenecyclopropanesviaboron-homologation/boron-allylation sequences possessing a quaternary stereocenter.
A multiple covalent crosslinked soft hydrogel for bioseparation
Authors: Liu Zhen , Fan Liuyin , Xiao Hua , Cao Chengxi
Published: January 2016

A multiple covalent crosslinked gel of poly(acrylamide–acrylic acid) was synthesized by using acrylic acid and acrylamide both as a monomer and as a covalent crosslinker.
A phosphinate-based near-infrared fluorescence probe for imaging the superoxide radical anion in vitro and in vivo
Authors: Zhang Jianjian , Li Chuwen , Zhang Rui , Zhang Fengyuan , Liu Wei , Liu Xiaoyan , Lee Simon Ming-Yuen , Zhang Haixia
Published: January 2016

A novel near-infrared (NIR), turn-on fluorescence probeCyRcontaining a phosphinate group as a recognizing moiety for the selective detection of O2˙−with a low limit of detection (LOD, 9.9 nM) was developed.
Hollow nanocrystals of silicoaluminophosphate molecular sieves synthesized by an aminothermal co-templating strategy
Authors: Wang Dehua , Yang Miao , Zhang Wenna , Fan Dong , Tian Peng , Liu Zhongmin
Published: January 2016

Hollow SAPO-56 nanocrystals are synthesized by an aminothermal co-templating strategy, which involves in situ phase transformation and post-synthetic etching processes.
Two modes of peri-interaction between an aldehyde group and a carboxylate anion in naphthalaldehydate salts
Authors: Saritemur Gizem , Nomen Miralles Laura , Husson Deborah , Pitak Mateusz B. , Coles Simon J. , Wallis John D.
Published: January 2016

The naphthalaldehydate anion shows two modes of interaction between its functional groups: either a carboxylate oxygen atom makes an n–π* interaction with the aldehyde carbon atom, or the aldehyde hydrogen atom is directed to the face of the carboxylate group.
Photo-assisted electrodeposition of manganese oxide on TaON anodes: effect on water photooxidation capacity under visible light irradiation
Authors: Singh Gujral Satnam , Simonov Alexandr N. , Fang Xi-Ya , Higashi Masanobu , Gengenbach Thomas , Abe Ryu , Spiccia Leone
Published: January 2016

Photo-assisted deposition of MnOxon the TaON anodes enhances activity and stability during water photooxidation.
An in situ approach to preparing Ni2P/SiO2 catalyst under mild conditions and its performance for the deoxygenation of methyl laurate to hydrocarbons
Authors: Chen Jixiang , Han Mengmeng , Zhao Sha , Pan Zhengyi , Zhang Zhena
Published: January 2016

An in situ approach was explored to prepare Ni2P/SiO2 from Ni/SiO2via a phosphorization process using triphenylphosphine as the phosphorus source.
Structural characterization of magnesium silicate hydrate: towards the design of eco-sustainable cements
Authors: Tonelli M. , Martini F. , Calucci L. , Fratini E. , Geppi M. , Ridi F. , Borsacchi S. , Baglioni P.
Published: January 2016

Magnesium-based cement is a very interesting eco-sustainable alternative to standard cements.
A metal-assisted templating route (S0M+I−) for fabricating thin-layer CoO covered on the channel of nanospherical-HMS with improved catalytic properties
Authors: Yang Fu , Zhou Shijian , Wang Haiqing , Long Saifu , Liu Xianfeng , Kong Yan
Published: January 2016

Nanospherical hexagonal mesoporous silica (HMS) with a functional mesochannel covered with thin-layer-dispersed cobalt oxide species was directly fabricatedviaa novel metal-assisted templating method (S0M+I−).
TEMPO-functionalized zinc phthalocyanine: synthesis, magnetic properties, and its utility for electrochemical sensing of ascorbic acid
Authors: Eken Korkut Sibel , Akyüz Duygu , Özdoğan Kemal , Yerli Yusuf , Koca Atıf , Şener M. Kasım
Published: January 2016

Zinc(ii) phthalocyanine (TEMPO-ZnPc), peripherally functionalized with 2,2,6,6-tetramethyl-1-piperidinyloxy (TEMPO) radicals is synthesized and its magneto structural and electrochemical sensing properties are investigated.
Characterization, fate and transport of floc aggregates in full-scale flocculation tanks
Authors: Vadasarukkai Yamuna S. , Gagnon Graham A.
Published: January 2016

In-line measurements of floc size distributions at different locations in a hydraulic flocculation tank using a holographic microscopy.
Pee power urinal – microbial fuel cell technology field trials in the context of sanitation
Authors: Ieropoulos Ioannis Andrea , Stinchcombe Andrew , Gajda Iwona , Forbes Samuel , Merino-Jimenez Irene , Pasternak Grzegorz , Sanchez-Herranz Daniel , Greenman John
Published: January 2016

This paper reports on the pee power urinal field trials, which are using microbial fuel cells for internal lighting.
Cardiovascular benefits of probiotics: a review of experimental and clinical studies
Authors: Thushara Ram Mohan , Gangadaran Surendiran , Solati Zahra , Moghadasian Mohammed H.
Published: January 2016

The microbiota inhabiting the human gastro-intestinal tract is reported to have a significant impact on the health of an individual.
Targeting the protein backbone with aryl halides: systematic comparison of halogen bonding and π⋯π interactions using N-methylacetamide
Authors: Zimmermann M. O. , Boeckler F. M.
Published: January 2016

Systematic plane scans reveal a seamless transition from σ-hole interactions with the carbonyl oxygen to interactions with the amide π-electrons at increasing distances.
Multi-functional silicone stamps for reactive release agent transfer in UV roll-to-roll nanoimprinting
Authors: Dumond J. J. , Low H. Y. , Lee H. P. , Fuh J. Y. H.
Published: January 2016

A novel bi-layer silicone nanoimprint mold capable of dual-functionality as both a lithographic template and a release agent transfer vehicle.
Catalytic asymmetric [3 + 2]-cycloaddition for stereodivergent synthesis of chiral indolyl-pyrrolidines
Authors: Arai Takayoshi , Tokumitsu Chihiro , Miyazaki Tomoya , Kuwano Satoru , Awata Atsuko
Published: January 2016

The stereochemical divergent synthesis of indolyl-pyrrolidines was accomplished using an imidazoline-aminophenol (IAP)–Ni(OAc)2 complex and a bis(imidazolidine)pyridine (PyBidine)–Cu(OTf)2 complex.
A versatile synthesis of chiral β-aminophosphines
Authors: Su Hsin Y. , Song Yixiong , Taylor Mark S.
Published: January 2016

A protocol for the synthesis of chiral β-aminophosphines by ring-opening of cyclic sulfamidates with metallated secondary phosphine oxides is described. It allows access to previously unknown derivatives having electron-deficient, electron-rich and sterically hindered P-aryl substituents.
Enzymatically crosslinked epsilon-poly-l-lysine hydrogels with inherent antibacterial properties for wound infection prevention
Authors: Wang Rui , Xu De-lei , Liang Lei , Xu Ting-ting , Liu Wei , Ouyang Ping-kai , Chi Bo , Xu Hong
Published: January 2016

Anin situforming hydrogel derived from epsilon-poly-l-lysine was crosslinked by the enzymatic catalysis method and showed excellent antibacterial properties for wound infection prevention.
Self-assembled porous film with interconnected 3-dimensional structure from 6sPCL-PMPC copolymer
Authors: Huang Lei , Zhang Songbai , He Liu , Zhang Chaoliang , Chen Yuanwei , Luo Xianglin
Published: January 2016

Biodegradable porous films with fibrous frame and good interconnectivity were prepared just by evaporating solvent of 6-arms star-shaped copolymer solution.
Synthesis of a functionalized fibrous adsorbent of high uptake capacity: a study on Pb(ii) uptake and simple acidic site model development
Authors: Kulkarni Vihangraj V. , Golder Animes Kumar , Ghosh Pranab Kumar
Published: January 2016

Development and exposure of acidic functional groups on lignocellulose biomaterials through destruction of lignin barrier by acid treatment.
A new avenue to the synthesis of highly substituted pyrroles: synthesis from N-propargylamines
Authors: Vessally Esmail
Published: January 2016

Pyrroles have attracted much attention due to their potential biological activities.
Syntheses, structures, electrochemical and optical properties of four transition metal complexes based on the 1-triazolyl-3-benzimidazolyltriazene ligand
Authors: Qiu Yanxuan , Miao Yu , Wang Zizhou , Li Zhixin , OuYang Zhijian , Yang Liu , Lin Wenning , Feng Weijin , Dong Wen
Published: January 2016

The crystal structures, electrochemical and optical properties of four transition metal complexes based on 1-triazolyl-3-benzimidazolyltriazene (H3TBIT) ligand have been reported.
Terpyridinyl dibenzo[b,d]furan and dibenzo[b,d]thiophene based tetrameric bismetallo-macrocycles
Authors: Wu Tun , Yuan Guo , Liu Die , Wang Meng , Li Yiming , Chen Mingzhao , Tao Hongwen , Wang Pingshan
Published: January 2016

Dibenzo[b,d]thiophene and dibenzo[b,d]furan based bisterpyridines were prepared. Direct self-assembly with Fe2+ led to metallo-macrocyclic mixtures. Utilizing the robust metallo-organic-ligands afforded the pure tetrameric macrocycles.
Deep adsorption desulfurization of liquid petroleum gas by copper-modified bentonite
Authors: Zhang Qian , Shi Li , Meng Xuan
Published: January 2016

Effects of different copper compounds, the amount of Cu2+ loading, the baking temperature and the valence state of copper on the adsorption desulfurization of LPG.
Filamentation of diamond nanoparticles treated in underwater corona discharge
Authors: Jirásek Vít , Lukeš Petr , Kozak Halyna , Artemenko Anna , Člupek Martin , Čermák Jan , Rezek Bohuslav , Kromka Alexander
Published: January 2016

Diamond nanoparticles after underwater discharge treatment get negative potential and form filaments.
Suppressing adverse intrinsic conduction of Bi2Te3 thermoelectric bulks by Sb and Cu co-substitutions via HPHT synthesis
Authors: Zhang Yuewen , Jia Xiaopeng , Sun Hairui , Sun Bing , Liu Binwu , Liu Haiqiang , Kong Lingjiao , Ma Hongan
Published: January 2016

Adverse intrinsic conduction is suppressed by co-substitution of Sb and Cu for Bi2Te3 thermoelectric bulks using a simple and rapid HPHT technique.
IDO as a drug target for cancer immunotherapy: recent developments in IDO inhibitors discovery
Authors: Qian Shan , Zhang Man , Chen Quanlong , He Yanying , Wang Wei , Wang Zhouyu
Published: January 2016

This review highlights the recent advances in research related to the role of IDO in immune escape in cancer and novel small-molecule IDO inhibitors with an emphasis on their chemical structures and modes of action.
Double conjugation strategy to incorporate lipid adjuvants into multiantigenic vaccines
Authors: Hussein Waleed M. , Liu Tzu-Yu , Maruthayanar Pirashanthini , Mukaida Saori , Moyle Peter M. , Wells James W. , Toth Istvan , Skwarczynski Mariusz
Published: January 2016

Conjugation of multiple peptides by their N-termini is a promising technique to produce branched multiantigenic vaccines.
Synthesis and characterization of magnetic elongated hollow mesoporous silica nanocapsules with silver nanoparticles
Authors: Cui Guijia , Sun Zebin , Li Haizhen , Liu Xiaoning , Liu Yan , Tian Yaxi , Yan Shiqiang
Published: January 2016

In this study, magnetic elongated hollow mesoporous silica nanocapsules (MSNCs) with center-radial pore channels were successfully fabricated for the first time by using the surfactant-template synthesis approach.
Recent advancements in perovskite solar cells: flexibility, stability and large scale
Authors: Ye Meidan , Hong Xiaodan , Zhang Fayin , Liu Xiangyang
Published: January 2016

This review focuses on the aspects of flexibility, stability and large scale, which are very essential for the future commercialization of PSCs, and many effective materials and fabrication strategies which have been reported to emphasize these three properties of PSCs will be introduced.
An electropolymerized molecularly imprinted polymer for selective carnosine sensing with impedimetric capacity
Authors: Wojnarowicz Agnieszka , Sharma Piyush Sindhu , Sosnowska Marta , Lisowski Wojciech , Huynh Tan-Phat , Pszona Maria , Borowicz Paweł , D'Souza Francis , Kutner Wlodzimierz
Published: January 2016

Functional monomers are designed for the development of a polymer with molecular cavities selective for the carnosine dipeptide recognition and quantification.
High-ampacity conductive polymer microfibers as fast response wearable heaters and electromechanical actuators
Authors: Zhou Jian , Mulle Matthieu , Zhang Yaobin , Xu Xuezhu , Li Er Qiang , Han Fei , Thoroddsen Sigurdur T. , Lubineau Gilles
Published: January 2016

Conductive fibers with enhanced physical properties and functionalities are needed for a diversity of electronic devices.
Multi-walled carbon nanotubes enhanced fungal colonization and suppressed innate immune response to fungal infection in nematodes
Authors: Shakoor Shumaila , Sun Lingmei , Wang Dayong
Published: January 2016

MWCNTs require the involvement of p38 MAPK signaling pathway to enhance toxicity of fungal infection.