bluuebunny/crossref_metadata_2025 huggingface dataset:
Advancing 3D Dental Implant FEA: Incorporating Biomimetic Trabecular Bone with Varied Pore Sizes in Voronoi Lattices
Authors: Alemayehu Dawit Bogale , Todoh Masahiro , Huang Song-Jeng
Published: March 2024

The human mandible's cancellous bone, which is characterized by its unique porosity and directional sensitivity to external forces, is crucial for sustaining biting stress. Traditional CAD models fail to fully represent bone's anisotropic structure and thus depend on simple isotropic assumptions. For our research, we use the latest versions of nTopology and Creo Parametric software to make biomimetic Voronoi lattice models that accurately reflect the complex geometry and mechanical properties of trabecular bone. The porosity of human cancellous bone is accurately modeled in this work using biomimetic Voronoi lattice models. The porosities range from 70% to 95%, which can be achieved by changing the pore sizes to 1.0 mm, 1.5 mm, 2.0 mm, and 2.5 mm. Finite element analysis (FEA) was used to examine the displacements, stresses, and strains acting on dental implants with a buttress thread, abutment, retaining screw, and biting load surface. The results show that the Voronoi model accurately depicts the complex anatomy of the trabecular bone in the human jaw, compared to standard solid block models. The ideal pore size for biomimetic Voronoi lattice trabecular bone models is 2 mm, taking into account both the von Mises stress distribution over the dental implant, screw retention, cortical bone, cancellous bone, and micromotions. This pore size displayed balanced performance by successfully matching natural bone's mechanical characteristics. Advanced finite element analysis (FEA) improves biomechanical understanding of how bones and implants interact by creating more accurate models of biological problems and dynamic loading situations. This makes biomechanical engineering better.
Comparison of Early Postoperative Diaphragm Muscle Function after Lobectomy via VATS and Open Thoracotomy: A Sonographic Study
Authors: Kocjan Janusz , Rydel Mateusz , Czyżewski Damian , Adamek Mariusz
Published: March 2024

Although a growing number of evidence emphasizes superior of VATS over conventional thoracotomy, still is little known about early postoperative diaphragm muscle function after lobectomy via these two approahces. To fill the gap in existing literature, we conducted comparative study between VATS and conventional thoracotomy in terms of postoperative diaphragm muscle function, assessing its contractility, strength, magnitude of effort and potential risk of dysfunction such as: atrophy and paralysis. A total of 59 patients (30 after VATS), who underwent anatomical pulmonary resection at our institution, were enrolled into this study. The control group was consisted of 28 health subjects without medical condition could contribute to diaphragm dysfunction. Diaphragm muscle was assessed before and after surgery using ultrasonography. We found that both surgical approaches were associated with postoperative impairment of diaphragm muscle function - compared to baseline data. Postoperative reduction of diaphragm contraction was demonstrated in all of 59 patients. In case of control group, the differences between measurements were no observed. We noted that lobectomy via thoracotomy was linked with greater percentage of patients with diaphragm paralysis or/and atrophy that VATS. Similar findings were observed in refer to diaphragm magnitude effort, as well as, diaphragm contraction strength, where minimal invasive surgery was associated with better diaphragm function parameters - in comparison to thoracotomy. Disturbance of diaphragm work was reported both at operated and non-operated side. Upper right and left lobectomy was connected with greater diaphragm function impairment than other segments. In conclusion, VATS technique seems to be less invasive than conventional thoracotomy providing a better postoperative function of a main respiratory muscle.
Linear-in-Temperature Resistivity and Planckian Dissipation Arise in a Stochastic Quantization Model of Cooper Pairs
Authors: Wang Xiao-Song
Published: March 2024

We suppose that a Cooper pair (CP) will experience a damping force exerted by the condensed matter. A Langevin equation of a CP in two dimensional condensed matter is established. Following a method similar to Nelson's stochastic mechanics, generalized Schr\"{o}dinger equation of a CP in condensed matter is derived. If the CPs move with a constant velocity, then the corresponding direct current (DC) electrical conductivity can be calculated. Therefore, a Drude like formula of resistivity of CPs is derived. We suppose that the damping coefficient of CPs in two dimensional cuprate superconductors is a linear function of temperature. Then the resistivity and scattering rate of CPs turn out to be also linear-in-temperature. The origin of linear-in-temperature resistivity and Planckian dissipation in cuprate superconductors may be the linear temperature dependence of the damping coefficient of CPs.
Assessment of Health Problems and Hazards Prevalent among Garment Workers in a Developing Country: An Approach using Risk Priority Number and Best-Worst Method
Authors: Islam Farzana
Published: March 2024

The contribution of readymade garment (RMG) industry is immense behind the rapid development of some countries with emerging economies. This industry is empowering these countries to provide employment opportunities for millions of people. However, the health as well as safety issues of the workers in this industry are often ignored, particularly in these developing countries. In recent times, because of the several undesirable and obnoxious conditions that exist in their working environments, they are vulnerable to various health related problems which are increasing at a staggering rate. The main purpose of this paper is to assess and prioritize the major health related problems faced by these garment workers in these countries where the economy is flourishing. In addition, the main hazards responsible for these health perils are also quantified. Data were collected from three different garment factories situated in different locations of Bangladesh. Thirty workers from each factory rated the frequency and severity of 14 health related issues. The health risks were then assessed and prioritized through risk priority number (RPN). Afterwards, three experts provided their opinion on the main hazards prevalent in the workplace of almost every garment factory in this country. These hazards were grouped into four main classes which are: 1) Physical 2) Ergonomic 3) Chemical and 4) Psychological hazards. The main classes were later divided into sub classes also. Best-worst method (BWM) was then applied to analyze these hazards by assessing their relative weights depending on the experts’ judgement. The results showed that the health issues faced by the workers in three different garment factories varied to some extent. The results obtained from the experts’ opinion indicated that physical hazards in the workplace are the most detrimental ones whereas the chemical hazards were the least harmful.
A Comprehensive Survey of Brain-Computer Interface Technology in Healthcare: Research Perspectives
Authors: Vimal Cruz Meenalosini , Jamal Suhaima , Sethuraman Sibi Chakkaravarthy
Published: March 2024

The Brain-Computer Interface (BCI) technology has emerged as a groundbreaking innovation with profound implications across diverse domains, particularly in healthcare. By establishing a direct communication pathway between the human brain and external devices, BCI systems offer unprecedented opportunities for diagnosis, treatment, and rehabilitation, thereby reshaping the landscape of medical practice. However, despite its immense potential, the widespread adoption of BCI technology in clinical settings faces several challenges. These include the need for robust signal acquisition and processing techniques, ensuring user safety and privacy, addressing ethical considerations, and optimizing user training and adaptation. Overcoming these challenges is crucial to unleashing the complete potential of BCI technology in healthcare and realizing its promise of personalized, patient-centric care. This review work underscores the transformative potential of BCI technology in revolutionizing medical practice. This paper offers a comprehensive analysis of medical-oriented BCI applications by exploring the various uses of BCI technology and its potential to transform patient care.
The Equations and Their Effects
Authors: Cardoso Carlos Eduardo Ramos
Published: March 2024

The study aims to explain the different effects between the multiplication, addition, division and subtraction equations. In this sense, multiplication and addition equations develop a new element or fact, meanwhile, division equations express information within the element or fact, subtraction is the selection of element or fact. Furthermore, for a multiplication and addition equation results in the new element or fact, it is necessary to depend on specific physical concepts, without extreme alteration, as it would result in the alteration of the element or fact. It is worth highlighting the importance of fixed values ​​in the equation to describe the specific nature of the element or fact. The study makes it possible to understand open equations (without solutions) in mathematics and physics, in addition to understanding existing equations. The study makes reference to the theory of obligatory necessity and the theory of differences between elements.
Minkowskian Approach to the Pseudorange Navigation Equations
Authors: Montesinos Ramón Serrano , Morales-Lladosa Juan Antonio
Published: March 2024

Our starting point is the covariant coordinate transformation equation of a relativistic positioning system in Minkowski space-time, which maps the receiver’s emission coordinates (proper times broadcast by the emitters) to its coordinates in some inertial reference frame. Bancroft’s analytical (closed-form) solution to the basic pseudorange navigation equations with four emitters is recovered and the subjacent elements are geometrically interpreted. The case of four static beacons is analized as a clarifying situation.
A New Opportunity for Mustangs: Finding a Place for Mustangs in the Eventing and Dressage Disciplines
Authors: Penny Cayla , Koncel Mary A. , Rutberg Allen T.
Published: March 2024

In 2023, the Bureau of Land Management (BLM) estimated that there were 68,928 mustangs living on United States public lands in 10 western states. The agency uses Appropriate Management Levels to determine the number of mustangs who need to be removed from the land. Once removed and processed, mustangs are sent to adoptions or sales events or retained in short-or long-term holding facilities. Adoptions and sales are the leading avenues for rehoming mustangs; however, the number of horses the BLM can place fluctuates annually and never approaches the greater number removed from the range. To explore opportunities for increasing the number of mustang adoptions, we conducted in-depth interviews with 23 horse trainers located on the U.S. East Coast, asking about participants’ training programs, relationships with horses, perceptions of mustangs, and challenges that mustangs face in the dressage and eventing industries. Participants had varying experiences with mustangs; however, all were willing to work with a mustang in some capacity. Participants voiced the need for more satellite adoption locations on the East Coast to decrease barriers to acquiring a mustang, notably cost and time, and for expanding existing training programs to include eventing and dressage.
Mitotic Poisons In Cancer Pharmacotherapy
Authors: Mohamed Alkhair , Boye Alex
Published: March 2024

Background: Cell proliferation and the cell cycle are fundamental to tumor development, with mitosis playing a crucial role in cell division. Understanding the complexities of the cell cycle and mitosis is critical for cancer research, especially in the context of developing therapeutic strategies. Objective: This review highlights mitotic poisons as potential anti-cancer pharmacotherapeutics, particularly their structural and functional group diversity presenting opportunity for semi-synthesis of new derivatives with multi-target mechanisms relevant for cancer pharmacotherapeutics. Also, the review explores naturally occurring mitotic poisons and inhibitors of microtubule-dependent molecular motors as promising cancer pharmacotherapeutics. Methods: A comprehensive review of literature from 2004 to 2023 was conducted, covering studies on cell proliferation, mechanism of cell cycle regulation, mitosis, cytokinesis, and anti-cancer drug development. The published literature was collected primarily from PubMed, Scopus, Medline, Web of Science Core Collections, Google Scholar and other relevant scientific databases using keywords including but not limited to mitotic poisons and cancer, sources of mitotic poisons, mechanism of mitotic poisons, targets of mitotic poisons and structural diversity of mitotic poisons. The efficacy and limitations of various mitotic poisons and their impact on different cancer types were examined. Recent advancements in targeted therapeutic interventions for various cancers were also explored. Results: The effectiveness and limitations of mitotic poisons, including Taxanes, Epothilones, Colchicine, Vinca alkaloids, Berberine, Laulimalide, and Pseudolaric acid B, were highlighted. Drugs targeting mitotic kinases such as CDKs, Aurora kinases, PLK1, and WEE1 inhibitors were reported. Inhibiting kinesin motor proteins such as Eg5 and KIF15 to interfere with spindle formation and cell division were discussed, along with specific genomic alterations in KIF genes and the discovery of KIFC1 as potential for future research and drug development. Conclusion: Targeting microtubules and mitotic kinases, along with inhibiting kinesin motor proteins, show promise for cancer pharmacotherapeutics. The combination of targeted therapies, patient stratification based on biomarkers (such as low alpha-1 acid glycoprotein and high p63 expression), and exploration of alternative natural sources of mitotic poisons and analogues can significantly advance cancer pharmacotherapy to improve patient outcomes.
Evaluating Distraction Safety Performance Indicators in an Urban Area of a LMIC: A Case Study of Yaoundé, Cameroon
Authors: Tezong Steffel Ludivin Feudjio , Tchinda Boris Feudjio , Fondzenyuy Stephen Kome , Usami Davide Shingo , Persia Luca
Published: March 2024

Distracted driving is a major cause of road traffic crashes in Yaoundé. Partly due to scarcity of enforcement, lack of evidence and investigation of distraction safety performance indicator (SPI), hindering evidence-based intervention. This study aimed to address this evidence gap by evaluating the distraction SPI using proven methodology. Data on distracted driving (handheld mobile device; interaction; eating/smoking/drinking) were collected from roadside observation on 36 randomly selected road sections carefully spread to cover the city. SPI were computed and weighted with traffic volume to ensure representativeness of values. A total of 41,004 drivers were observed (38,248 in car; 1,116 in van; 977 in truck; 663 in bus). The prevalence of distracted driving in Yaoundé is 13.69% for the three distractions type combined. The prevalence is 7.84% for interaction, 4.89% for handled mobile device usage and 0.96% for eating/smoking/drinking. Leveraging these insights, a seven year (2024 - 2030) fighting strategy aiming at halving the prevalence was developed. The strategy contains intervention including on legislation/enforcement, which have been proven effective. This study, pioneer in Yaoundé, provide stakeholders with evidence of the issue and measures to implement and can also serve when developing road safety strategy.Future research should consider investigation at national level.
Impact of Reducing Statistically Small Population Sampling on 2 Threshold Detection in FBG Optical Sensing
Authors: Cibira Gabriel , Glesk Ivan , Dubovan Jozef , Benedikovič Daniel
Published: March 2024

Statistical denoising techniques have been well studied, however many challenges still remain. This 9 article focuses on determining the least necessary number of significant samples in a statistical pop-10 ulation sampling, while minimizing the impact on the statistical detection of the fiber Bragg grating 11 (FBG) power spectra. This is achieved by using Bayesian decision making, small population statis-12 tics while excluding false detection. First, we investigate the impact of two-sided sliding window 13 technique applied near the cell under the test. The window size varies from 8 to 60 samples. The 14 considered maximum size of population sampling is connected with the number of wavelength 15 samples within the bandwidth of the symmetrical FBG power spectra peaks. Regarding the sym-16 metry of FBG power spectra peaks and the possible reduction of computational demands, we inves-17 tigate the impact of a one-sided sliding window. This enables to achieve less processing latency for 18 real time applications thus brings benefits to FBG-based fiber optical sensing. Both, two- and one-19 sided small population sampling techniques are then experimentally verified. Detection results are 20 analyzed in depth via calculating detection thresholds by using the small size window sliding along-21 side the waveband. From results achieved, it was found that the normality three-sigma rule does 22 not need to be followed while using the small population sampling. Experimental demonstrations 23 and analyses showed that the proposed concept of denoising and statistical threshold detection 24 based on the sliding window does not depend on the prior knowledge of probability distribution 25 functions of the FBG power spectra peaks level and background noise. We have also found that the 26 thresholds’ adaptability mainly depends on the statistical numerical characteristics of the above ad-27 ditive mixture of the FBG power spectra peaks signals and background noise.
Ecological Safety Assessment and Convergence of Resource-Based Cities in Yellow River Basin
Authors: Liu Changju , Zhai Xiaowei , Ai Keyu
Published: March 2024

Promoting the sustainable development of resource-based cities is of great significance to the ecological protection and high-quality development of the Yellow River Basin. Combining the environmental status and economic development, we objectively evaluate the ecological safety level of resource-based cities in the Yellow River Basin, compare and analysis the main factors affecting the ecological safety of different resource-based cities, and formulate precise and differentiated ecological safety protection measures in river basins to achieve high-quality development. Taking the Yellow River Basin as an example, this paper analyses the ecological level of the Yellow River Basin based on the theory of sustainable development, calculates the ecological safety level of 30 resource-based cities in the Yellow River Basin from 2006 to 2020 by TOPSIS model, and makes convergence analysis by classification. Through the DID empirical test of sustainable development planning policy on ecological safety factors, distinguish the development characteristics of different resource-based cities. The results show that: (1) the ecological safety level of resource-based cities in the Yellow River Basin is generally developing well, and there are differences among different types of resource-based cities; (2) the kinetic energy of sustainable development of resource-based cities in the Yellow River Basin is mainly industrial transformation, and the power of science and technology is insufficient; (3) local governments pay limited attention to environmental protection, and the sustainable development planning of resource-based cities in 2013 mainly promotes the adjustment of industrial structure of resource-based cities.
Correlating Quantitative and Genomic SARS-CoV-2 Wastewater Data with Clinical Metrics in Metropolitan Perth, Western Australia
Authors: Gazeley Jake , Lee Terence , Knight Daniel R , Shivarev Alexander , Gordon Cameron , Speers David , Barth Dylan D , Maticevic Jelena , Hodge Meredith , Armstrong Paul , Knight Paul , Sjollema Sandra , Levy Avram
Published: March 2024

Wastewater-based epidemiology (WBE) has emerged as a key method for continuous monitoring of COVID-19 prevalence including circulating SARS-CoV-2 lineages. WBE addresses limitations of traditional clinical COVID-19 surveillance such as clinical test availability, fluctuating testing rates and increased reliance on rapid antigen tests. Our study in Perth, Western Australia, found a significant positive correlation between SARS-CoV-2 concentrations in wastewater and clinical PCR positivity rates (rs = 0.772; p < 0.001) over an 18-month period that included four successive COVID-19 waves. A strong positive correlation was apparent between the proportions of SARS-CoV-2 lineages in wastewater and clinical cases within the same region (rs = 0.728; p < 0.001), including earlier detection of Omicron and recombinant lineages in wastewater before clinical case confirmation. The successful integration of WBE with healthcare data underscores its critical role in enhancing public health decision-making and pandemic management. This approach not only demonstrates the value of WBE in current global health surveillance efforts but also highlights the potential of WBE to address future public health challenges, as a comprehensive disease monitoring and response approach.
Evolution of Hottest Research Topics in E-Mobility over Period of 20 Years and How It Will Help State of Kuwait in Catching Up
Authors: Hamwi Hidab , Ottesen Andri , Alasseri Rajeev , Aldei Sara
Published: March 2024

This article examines the evolution of the most extensively researched subjects in E-mobility during the previous two decades. The objective of this analysis is to identify the lessons that the State of Kuwait, which is falling behind other nations in E-mobility, can absorb in its efforts to embrace adoptions of electric vehicles (EVs). To strengthen the body of knowledge and deter-mine the most effective and efficient route to an "EV-ready" nation, the authors compiled data on the latest developments in the EV industry. A bibliometric analysis was performed on 3,962 articles utilizing the VOSviewer software, which identified six noteworthy clusters that warranted further attention. Additionally, we examine the sequential progression of these clusters as follows: 1. The environmental ramifications of electric mobility; 2. Advancements in electric vehicle technology, including range extension and soundless engines; and capital (CAPEX) and operational (OPEX) expenditures of purchasing and operating EVs. 3. Concerns regarding effectiveness and durability of EV batteries, 4. Availability of EV charging stations and grid integration, 5. Charging time, and finally 6. Origin and source of the energy utilized in the development of e-mobility. We are of the opinion that by delineating the critical aspects of e-mobility development, policymakers and decision-makers in Kuwait will be better equipped to formulate timely and economical choices pertaining to sustainable transportation.
Solar Flare Prediction from Extremely Imbalanced Multivariate Time Series Data using Minimally Random Convolutional Kernel Transform
Authors: Saini Kartik , Alshammari Khaznah , Hamdi Shah Muhammad , Filali Boubrahimi Soukaina
Published: March 2024

Solar flares are characterized by sudden bursts of electromagnetic radiation from the Sun’s surface, and caused by the changes in magnetic field states in solar active regions. Earth and its surrounding space environment can suffer from various negative impacts caused by solar flares ranging from electronic communication disruption to radiation exposure-based health risks to the astronauts. In this paper, we address the solar flare prediction problem from magnetic field parameter-based multivariate time series (MVTS) data using multiple state-of-the-art machine learning classifiers that include MINImally RandOm Convolutional KErnel Transform (MINIROCKET), Support Vector Machine (SVM), Canonical Interval Forest (CIF), Multiple Representations SEQuence Learner (Mr-SEQL), and Long Short-Term Memory (LSTM)-based deep learning model. Our experiment is conducted on the on the Space Weather ANalytics for Solar Flares (SWAN-SF) benchmark data set, which is a partitioned collection of MVTS data of active region magnetic field parameters spanning over 9 years of operation of the Solar Dynamics Observatory (SDO). The MVTS instances of the SWAN-SF dataset are labeled by GOES X-ray flux-based flare class labels, and attributed to extreme class imbalance because of the rarity of the major flaring events (e.g., X and M). As a performance validation metric in this class-imbalanced dataset, we used the true skill statistic (TSS) score. Finally, we demonstrate the advantages of the MVTS learning algorithm MINIROCKET, which outperformed the aforementioned classifiers without the need for essential data preprocessing steps such as normalization, statistical summarization, and class imbalance handling heuristics.
Development of a Conversion Table to Link Clinical Scale Scores to ICF Qualifiers: Insights from a Survey of Healthcare Professionals
Authors: Umemori Shu , Ogawa Mao , Yamada Shin , Komatsu Masayo , Oikawa Emiko , Okamoto Yasuyo , Katoh Masaki , Shirasaka Tomohide , Abiko Kagari , Moriizumi Shigehiro , Matsuo Yuichiro , Tohyama Harukazu , Mukaino Masahiko
Published: March 2024

In clinical practice, patient assessments rely on established scales. Integrating data from these scales into the International Classification of Functioning, Disability, and Health (ICF) framework has been suggested; however, a standardized approach is lacking. Herein, we tested a new approach to develop a conversion table translating clinical scale scores into ICF Qualifiers based on a clinician survey. The survey queried rehabilitation professionals about which functional independence measure (FIM) item scores (1-7) corresponded to the ICF qualifiers (0-4). A total of 458 rehabilitation professionals participated. The survey findings indicated a general consensus on the equivalence of FIM scores with ICF qualifiers. The median value for each item remained consistent across all item groups. Specifically, FIM 1 had a median value of 4; FIM 2 and 3 had median values of 3; FIM 4 and 5 had median values of 2; FIM 6 had a median value of 1; and FIM 7 had a median value of 0. Despite limitations due to the irreconcilable differences between the frameworks of existing scales and the ICF, these results underline the ICF's potential to serve as a central hub for integrating clinical data from various scales.
Luminescence and Electron-hole Trapping Centers in Mn-doped α-Ca2P2O7
Authors: Nurakhmetov Turlybek , Alibay Temirulan , Zhangylyssov Keleshek , Nurpeissov Aibek , Pazylbek Sapargali , Griesiute Diana , Zarkov Aleksej , Kareiva Aivaras
Published: March 2024

The mechanisms of formation of induced intrinsic and impurity radiative states, which consist of intrinsic and impurity electron-hole trapping centers in irradiated Ca2P2O7-Mn and Ca2P2O7 phosphates, were investigated using thermoactivation and vacuum-ultraviolet spectroscopy methods. These centers are excited at photon energies of 4.0 eV and 4.5 eV, which are within the matrix's transparency region. New radiative induced states at 3.06 eV and 2.92 eV are demonstrated to be generated upon the excitation of anions by photons with energies of 5.0 and 5.64 eV. This process is due to charge transfer from the ion to the impurities, specifically Mn^2+ O^2- Mn^2+ and the neighboring ion O^2- (P2O7)^4-. Furthermore, upon the excitation of matrix anions with photon energies exceeding the band gap (8.0 - 8.25 eV), electron trapping by impurities such as Mn^2+ and (P2O7)^4- ions results.
Clinical and laboratory parallels of carbohydrate metabolism changes in thyroiditis
Authors:   Dagestan State Medical University, Makhachkala, Russian Federation, Magomedova I.M. , Kamalov K.G. ,   Dagestan State Medical University, Makhachkala, Russian Federation, Arslanbekova A.Ch. ,   Dagestan State Medical University, Makhachkala, Russian Federation, Arslanbekova D.A. ,   National Medical Research Center for Endocrinology, Moscow, Russian Federation
Published: March 2024

The number of people suffering from endocrine disorders is increasing. The interaction between diseases such as diabetes and various thyroid diseases is of some interest. This article presents the results of investigating the effect of different thyreopathies on carbohydrate metabolism and lipid profile, which may have some significance for the possible management tactics of these patients. Objective. To demonstrate clinical and laboratory features of carbohydrate metabolism disorders in different thyroid diseases. Patients and methods. Patients were examined during the period 2021–2022, among them were patients with thyroid diseases: hypothyroidism, thyrotoxicosis, endemic goiter without dysfunction. A total of 257 patients were examined, including 96 patients with hypothyroidism, 29 with thyrotoxicosis, and 93 with endemic goiter, as well as 38 patients without thyroid diseases (the control group). Results and discussion. When comparing the results of plasma glucose and glycated hemoglobin (HbA1c) tests for all groups, a significant increase in their levels was revealed. Patients with hypothyroidism were found to have higher cholesterol levels compared to the control group, and significant differences were also established in the evaluation of low-density lipoproteins in patients with endemic goiter. Conclusion. Various thyroid diseases lead to certain metabolic disorders, namely, deterioration of carbohydrate metabolism and a slight deterioration of lipid profile. Key words: thyroid gland, carbohydrate metabolism, endemic goiter, hypothyroidism, thyrotoxicosis, euthyroidism, lipid metabolism
Inflammatory bowel diseases and helminth infections
Authors:   Research Clinical Institute of Childhood of the Ministry of Health of the Moscow Region, Moscow, Russian Federation, Khavkin A.I. ,   N.I.Pirogov Russian National Research Medical University, Moscow, Russian Federation, Novikova V.P. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Trapeznikova A.Yu. ,   Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation, Yablokova E.A. ,   Research Clinical Institute of Childhood of the Ministry of Health of the Moscow Region, Moscow, Russian Federation, Erokhina M.I. ,   Research Clinical Institute of Childhood of the Ministry of Health of the Moscow Region, Moscow, Russian Federation, Chibrina E.V. ,   Research Clinical Institute of Childhood of the Ministry of Health of the Moscow Region, Moscow, Russian Federation
Published: March 2024

Inflammatory bowel disease (IBD), including nonspecific ulcerative colitis and Crohn's disease, are chronic recurrent immunemediated conditions. The prevalence of this pathology among residents of developed countries has increased significantly in recent decades. However, in about a third of the world's countries, mainly in developing countries with poor sanitary and hygienic conditions, these diseases are practically absent. According to hygienic theory, modern, overly hygienic environmental conditions negatively affect the human immune system. This predisposes genetically susceptible individuals to developing inflammatory diseases such as IBD. According to modern recommendations, immunosuppressive drugs such as azathioprine, 6-mercaptopurine and methotrexate are used to treat this pathology. However, scientists are looking for new ways to solve this problem. One of the promising directions in this area is the study of the action of helminth-derived immunosuppressive molecules. The hygienic hypothesis suggests an inverse association between parasitic infections and the incidence of IBD. Epidemiological, experimental and clinical evidence support the idea that helminths may contribute to reducing the number of inflammatory bowel diseases. Data have been accumulated on the importance of regulatory pathways, such as regulatory T-cells, by which helminths induce such protection. The study of the mechanisms of influence of helminths on innate and acquired immune responses may contribute to the development and introduction into therapeutic practice of new therapies for IBD. This article presents a literature review on the relationship of helminths and IBD, as well as the possibility of using helminths or helminth-derived immunosuppressive molecules in the therapy of this pathology. Key words: helminth infections, ulcerative colitis, Crohn's disease
Modern approaches to the diagnosis of hemolacria in pediatric practice: a review of the literature and a clinical case
Authors:   Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation, Sadovnikova I.V. , Khavkin A.I. ,   Research Clinical Institute of Childhood, Ministry of Health of the Moscow Region, Moscow, Russian Federation,   Veltischev Research and Clinical Institute for Pediatrics and Pediatric Surgery of the Pirogov Russian National Research Medical University Research Clinical Institute of Pediatrics, Moscow, Russian Federation, Egorskaia A.T. ,   Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation, Egorskaia E.T. ,   Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation, Zastelo E.S. ,   Privolzhsky Research Medical University, Nizhny Novgorod, Russian Federation, Mamedov S.S. ,   Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russian Federation
Published: March 2024

The article is devoted to the problem of the occurrence of bloody tears; emphasis is placed on the features of pathology in the pediatric cohort of patients. The aim of the work is to identify the features of modern approaches to the diagnosis of hemolacria in children. The article is based on the analysis of literature data. The authors present up-to-date data on the etiopathogenesis of hemolacria: injuries, operations, inflammatory and infectious processes, anatomical features of the lacrimal apparatus, systemic diseases associated with pathology of the hemostasis system, vascular disorders, psychological genesis, neoplasms, vicarious menstruation, as as taking certain medications. Modern approaches to the diagnosis of hemolacria are discussed. A thorough examination of patients will allow you to correctly determine the tactics of treatment. The article provides information about idiopathic hemolacria, the diagnosis of which requires the exclusion of other causes of bloody tears. Statistical features of idiopathic hemolacria, as well as concomitant conditions are described; the most common are headache, i.e. migraine, epistaxis, hematohidrosis. The review is illustrated by a clinical case of hemolacria in a 13-year-old girl with the development of epistaxis in 1 month. Examination of the patient revealed the idiopathic nature of the pathology. Key words: hemolacria, bloody tears, diagnostics, idiopathic hemolacria, children
SYNTHESIZE OF TiO2 NANOPARTICLES BY PLANETARY BALL MILL FOR DYE-SENSITIZED SOLAR CELLS (DSSC) PHOTOELECTRODE APPLICATION
Authors: Nurlaela Ai , Yuniarti Elvan , Saptari Siti Ahmiatri
Published: March 2024

In this study, the production of TiO2 nanoparticles from microcrystalline powder was accomplished using the high-energy ball milling (HEBM) technique. Three samples were milled for 0.5, 1, and 1.5 hours. The unmilled powder was also characterized as a comparison. The X-ray diffraction (XRD) technique was utilized to investigate the changes in the microstructure of the milled powders over time. The XRD curve of milled samples showed the broadening of the diffraction peaks, which indicates a decrease in particle size after the milling process. Using the Debye–Scherrer relation, obtain the particle size that decreased from 138.43 nm before milled to 76.65 nm after 0.5 hours milled, 90.63 nm after 1 hour milled, and 83.05 nm after 1.5 hours milled. XRD analysis also showed that TiO2 was in an anatase phase before and after milling. Furthermore, two samples of TiO2, unmilled and after 0.5 hours milled, were used as a working photoelectrode of DSSC with dye from mustard leaves. DSSC efficiency was measured with a 1000-watt halogen lamp. The efficiency of DSSC with photoelectrodes using TiO2 after 0.5 hours milled, which is 0.1715, was higher than using TiO2 before milled, which is 0,0987. The Large surface area in TiO2 enhances the efficiency of DSSC, indicating that the HEBM technique is quite suitable for producing these nanoparticles for this aim.
IDENTIFICATION OF PHYSICAL OCEANOGRAPHIC PARAMETERS AND MIXING TYPES AT THE TRANSITIONAL SEASON I IN THE ESTUARY OF AIR MANNA REGENCY SOUTH BENGKULU
Authors: Supiyati Supiyati , Sari Devi Permata , Ekawita Riska , Johan Septi , Sudirman Sudirman
Published: March 2024

The recent increase in community activity in the Air Manna Estuary of the South Bengkulu regency, will affect the physical condition of the estuary. Therefore, this research were to determine of the physical oceanographic parameters such as temperature, salinity, current velocity, tidal and the mixing type in the Air Manna estuary, South Bengkulu Regency at the transitional season I. The method used is the measurement of field data directly during high tide and low tide conditions as well as descriptive and quantitative data analysis. The results showed that the characteristics of the physical oceanographic pharameters in the Air Manna Estuary were influenced by tidal condition. The highest current speed at the mouth of the estuary is 2.6 m/s at low tide and 2.2 m/s at high tide, with the highest temperature in the upstream estuary of 27.49oC towards the sea during high tide conditions. The low salinity in the middle of the estuary of 0.99 ppt increases towards the sea with a relatively smaller distribution of salinity at low tide.The mixing type in the Air Manna Estuary is the Salt wedge estuary which has a well-certified mixing pattern, with an estuary number of 0.00019.
RICE SAMPLE VAPORIATION METHOD ON METER TESTING RESISTIVE WATER CONTENT BASED ON ULTRASONIC MIST
Authors: Syahwir Irawati Dewi , Dinny Fauzia Nur , Ihsan Firman Khoirul
Published: March 2024

Percentage moisture content is an important factor in assessing the quality and quantity of agricultural commodities, such as rice. The measurement of moisture content is very important to evaluate the moisture content of rice, which directly affects its quality. However, the measurement of moisture content takes a long time, so it is necessary to have an evaporation method to shorten the time so that the moisture content of the sample is as required. In this study, the method chosen was the evaporation method with ultrasonic mist. The results showed that this ultrasonic fog controller evaporation system successfully increased the moisture content of rice samples according to the criteria needed to be used in resistive-type moisture meter testing. The ultrasonic mist controller evaporation system can increase the water content of rice samples according to the criteria needed for use in resistive-type moisture meter testing, with an average increase of 0.9% within 15 minutes, 3.4% within 30 minutes, and 4.1% within 1 hour.
SYNTHESIS AND CHARACTERIZATION ANALYSIS OF FE3O4/SiO2 CORE SHELL
Authors: Cassia Diva , Sugihartono Iwan , Isnaeni Isnaeni , Soewoto Haswi Purwandanu , Alaih Akhmad Futukhillah Fataba , Triyono Djoko , Mohar Rahmat Setiawan , Tiam Tan Swee
Published: March 2024

Fe3O4/SiO2 core shell synthesis has been carried out, and its characteristics has been analyzed to be used as a photocatalyst using co-precipitation and sol-gel method. Fe3O4 is used as the core material to eliminate the difficulty of separating the photocatalyst powder from the solution medium, SiO2 is used to avoid oxidation by preventing the Fe3O4 core from coming into direct contact with the solution. The samples were then characterized using X-Ray Diffraction (XRD), Fourier Transform Infra-Red (FTIR), and Vibrating Sample Magnetometer (VSM). The XRD and FTIR results showed that the crystal structure and movement of the sample molecules matched the standard characteristics from previous studies. The VSM characterization results show that SiO2 succeeded in reducing the value of the magnetization of Fe3O4, which proves that Fe3O4 has been successfully coated by SiO2.
Kemandirian Ekonomi Pesantren Melalui PT Ngabar Mandiri Sejahtera (Studi pada Pondok Pesantren Wali Songo Ngabar)
Authors: Muhamad Ulfi  , Luhur Prasetiyo
Published: March 2024

Independence can be interpreted as the potential to be able to produce to meet their own needs and help others who do not depend on others in carrying out or carrying out a business process. Likewise, in the management of an institution. Economic independence in Islamic educational institutions means that these institutions can choose and carry out activities to survive in a better way. This qualitative descriptive study aims to identify and analyze the economic activities and innovations carried out by PT Ngabar Mandiri Sejahtera and their impact on finansial independence at the Wali Songo Islamic Boarding School, Ngabar.  Primary data were obtained from interviews and in-depth observations of and documentation of business unit managers and administrators of the Waqf Maintenance and Development Foundation of the Wali Songo Islamic Boarding School, Ngabar. Secondary data was obtained from the documentation and financial records of PT Ngabar Mandiri Sejahtera. The results show that PT Ngabar Mandiri Sejahtera has various kinds of business units to support the independence of the Wali Songo Islamic Boarding School through its business units, including NBC Supermarkets, Ngabar Food Courts, Ngabar Hostel and Meeting Hall, Ngabar Mart, Ngabar Bistro, Cafeteria Al Azhar, Ngabar Perfume, and Ngabar Laundry. The innovations carried out included developing the type of business, using smart card payment methods cashless, and establishing relationships with third parties to supply the needs of Islamic boarding schools. The impact of economic activities through PT Ngabar Mandiri Sejahtera for the internal boarding school is well-organized sales management, asset improvement, and operating profit. The external is to open up job opportunities for the community around the Wali Songo Islamic Boarding School, Ngabar.
Konsep Talak Perspektif Wahbah Az-Zuhaili, Muhammad Jawad Mughniyah, dan Kompilasi Hukum Islam
Authors: Yuniarti Arista , Saifullah Saifullah
Published: March 2024

Jurisprudence prioritizes the right of divorce to be held by the husband. The purpose of this qualitative research with a literature study approach is to describe and analyze: 1) the concept of divorce, which can cause the breakup of marriage relations according to Wahbah Az-Zuhaili, Muhammad Jawad Mughniyah, and the Compilation of Islamic Law, and 2) what is the legal term used by Wahbah Az-Zuhaili, Muhammad Jawad Mughniyah, and the Compilation of Islamic Law (KHI) in determining divorce. The results of this study indicate whether the husband intends to become the legal ruler or not to divorce and prohibit divorce without any cause. The difference lies in the editorial divorce used and the witness in the divorce. As for instituting the law of Wahbah Az-Zuhaili, Muhammad Jawad Mughniyah both used the Al-Qur'an, Sunnah, and ijmak. The difference lies in the way of understanding sunnah and ijmak. Jawad does not use kiyas in determining the law but uses reason so that the relevance of the divorce provisions of the two figures, namely Wahbah Az-Zuhaili, Muhammad Jawad, and KHI, in determining the divorce issue lies in the procedure for its implementation. According to the two figures, divorce does not need to be done in front of the courtroom wherever the divorce is pronounced, so divorce falls at that moment because divorce is the husband's right. However, in Indonesia, divorce must be carried out before a court hearing because the husband cannot guarantee his right to divorce. Also, the wife gets protection and legal certainty.
Efektivitas Sistem Informasi Manajemen Nikah Berbasis Web dalam Sistem Pelayanan Kartu Nikah Digital
Authors: Fahruzi Airul , Rohmanu Abid , Junaidi Ahmad
Published: March 2024

This research is motivated by the Decree of the Minister of Religion of the Republic ofIndonesia Number 892 of 2019, concerning Web-Based Simkah in the Digital MarriageCard service system following the PMA Circular Letter of the Director General ofIslamic Community Guidance Number B-2361/Dt.III/PW.01/07/2021 concerningCards Digital Marriage. This research aims to describe the application of the Web-BasedMarriage Management Information System orSimkah Web in the Digital MarriageCard service system in KUA Pitu District, Ngawi Regency, and its effectiveness. Themethod used in this research is a descriptive method with a qualitative approach, namelyresearch that seeks to reveal and interpret a developing phenomenon. The researchresults show thatSimkah Web in KUA Pitu District, Ngawi Regency, has beenimplemented but is still hampered, especially regarding the readiness of KUA humanresources. In several cases, people found difficulties using this application, including thecomplexity of inputting marriage data in printing Digital Marriage Cards. Thus, it canbe concluded that the implementation ofSimkah Web has helped make it easier for theKUA to collect marriage data throughout Indonesia. However, it is still not fullyimplemented effectively by the community as a basis for printing Digital MarriageCards in the KUA of Pitu District
Efektivitas Penanganan Dispensasi Kawin Pasca Berlakunya Undang-Undang Nomor 16 Tahun 2019 di Ponorogo
Authors: Kusna Nur Laela , Huda Miftahul , Hanifuddin Iza
Published: March 2024

This research was motivated by the increasing number of requests for marriage dispensation atthe Ponorogo Religious Court after the enactment of Law no. 16 of 2019. This law is expectedto provide a major transformation in efforts to prevent early marriage with all its derivativesocial problems. This field research using a qualitative approach produced two conclusions,namely: (1) in terms of the factors causing the increase, Law Number 16 of 2019 has not beeneffective. The data that has been analyzed shows that apart from the same causal factors as thecausal factors before the existence of Law Number 16 of 2019, such as being pregnant out ofwedlock, having given birth to a child, parents are worried that their children will fall intothings that are prohibited by religion, low economic conditions, poor education. low, there is anew causal factor, namely public ignorance about the increase in the marriage age limit. If werefer to the definition made by Soejono Soekanto, the law is said to be effective if it is able toachieve its objectives and (2) Judges as law enforcers in handling marriage dispensation casesare guided by existing regulations and are deemed to have been effective in implementing LawNumber 16 of 2019 in the Religious Courts. The judge has taken action in the form of giving adecision based on the law and actual factual circumstances. Considerations in the determinationrefer to existing regulations, especially Law no. 16 of 2019.