bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel digital methods for gathering intensive time series data in mental health research: scoping review of a rapidly evolving field
Authors: Schick Anita , Rauschenberg Christian , Ader Leonie , Daemen Maud , Wieland Lena M. , Paetzold Isabell , Postma Mary Rose , Schulte-Strathaus Julia C. C. , Reininghaus Ulrich
Published: November 2022

Recent technological advances enable the collection of intensive longitudinal data. This scoping review aimed to provide an overview of methods for collecting intensive time series data in mental health research as well as basic principles, current applications, target constructs, and statistical methods for this type of data.

In January 2021, the database MEDLINE was searched. Original articles were identified that (1) used active or passive data collection methods to gather intensive longitudinal data in daily life, (2) had a minimum sample size of N ⩾ 100 participants, and (3) included individuals with subclinical or clinical mental health problems.

In total, 3799 original articles were identified, of which 174 met inclusion criteria. The most widely used methods were diary techniques (e.g. Experience Sampling Methodology), various types of sensors (e.g. accelerometer), and app usage data. Target constructs included affect, various symptom domains, cognitive processes, sleep, dysfunctional behaviour, physical activity, and social media use. There was strong evidence on feasibility of, and high compliance with, active and passive data collection methods in diverse clinical settings and groups. Study designs, sampling schedules, and measures varied considerably across studies, limiting the generalisability of findings.

Gathering intensive longitudinal data has significant potential to advance mental health research. However, more methodological research is required to establish and meet critical quality standards in this rapidly evolving field. Advanced approaches such as digital phenotyping, ecological momentary interventions, and machine-learning methods will be required to efficiently use intensive longitudinal data and deliver personalised digital interventions and services for improving public mental health.
New Directions in Political History
Authors: Broxmeyer Jeffrey D. , Andersen Lisa M.F. , Barreyre Nicolas , Edwards Rebecca , Lansing Michael J. , Lumba Allan E.S. , White Tara Y.
Published: November 2022

This roundtable takes up old themes and new perspectives in the field of political history. Scholars engage with six questions across three main categories: the scope of the field, current debates, and teaching. The first two questions ask how we should think about political power and the boundaries of what constitute political history. The section on current debates interrogates the relationship between governing and social movements during the GAPE, and how to situate the political violence of the January 6, 2021, Capitol Hill riot in historical perspective. The final section on teaching takes up two very different challenges. One question is a perennial concern about connecting with students in the classroom about political history. The other dilemma is how to respond to the growing cascade of censorship laws passed by state legislatures that prohibit the teaching of so-called “divisive concepts.”
Aedes Aegypti—Insights on the Impact of Water Services
Authors: Novaes Carlos , Silva Pinto Francisco , Marques Rui Cunha
Published: November 2022

Epidemics in general and dengue in particular surcharge the health services and the economy. However, the fighting actions are circumscribed to the health sector despite the known positive economic impacts that the investments in water supply and sanitation services (WSS) may cause on society and public health. Besides the fact that urban WSS infrastructure is closely linked to disease prevention, in Brazil, the user's perception and demand are very few and many institutional aspects, like the integration between local WSS, health, environment, and development of city councils, need to be improved and better aligned. In this way, disease control and vector density reduction remain challenges to be overcome. This article addresses the need for greater institutionalization of urban WSS relating them to health aspects from official data. It concludes that the negative impacts of lacking universal access to WSS on dengue and other mosquito diseases are dispersed in all cities, regions, and populations regardless of their degree of development. Furthermore, contrary to what is normally emphasized, the analysis carried out shows that the lack of urban stormwater management systems may be an important component of WSS in preventing the proliferation of dengue disease.
Are Dipolarization Fronts a Typical Feature of Magnetotail Plasma Jets Fronts?
Authors: Richard L. , Khotyaintsev Yu. V. , Graham D. B. , Russell C. T.
Published: November 2022

Plasma jets are ubiquitous in the Earth's magnetotail. Plasma jet fronts (JFs) are a seat of particle acceleration and energy conversion. JFs are commonly associated with dipolarization fronts (DFs), which are often characterized by solitary sharp large‐amplitude increases in the northward component of the magnetic field Bz. However, MHD and kinetic instabilities can develop at JFs and disturb the front structure which questions on the occurrence of solitary DFs at the JFs. We investigate the structure of JFs using 5 years (2017–2021) of the Magnetospheric Multiscale observations in the central plasma sheet (CPS) in the Earth's magnetotail. We compiled a database of 2394 CPS jets. We find that 42% of the JFs are associated with large‐amplitude changes in Bz. However, solitary DFs constitute a quarter of these large‐amplitude events, while the rest are associated with more complex structures.
A new strategy to minimize humidity influences on acoustic wave ultraviolet sensors using ZnO nanowires wrapped with hydrophobic silica nanoparticles
Authors: Guo Yihao , Zhou Jian , Ji Zhangbin , Liu Yanghui , Cao Rongtao , Zhuo Fengling , Tan Kaitao , Duan Huigao , Fu Yongqing
Published: November 2022

Surface acoustic wave (SAW) technology has been widely developed for ultraviolet (UV) detection due to its advantages of miniaturization, portability, potential to be integrated with microelectronics, and passive/wireless capabilities. To enhance UV sensitivity, nanowires (NWs), such as ZnO, are often applied to enhance SAW-based UV detection due to their highly porous and interconnected 3D network structures and good UV sensitivity. However, ZnO NWs are normally hydrophilic, and thus, changes in environmental parameters such as humidity will significantly influence the detection precision and sensitivity of SAW-based UV sensors. To solve this issue, in this work, we proposed a new strategy using ZnO NWs wrapped with hydrophobic silica nanoparticles as the effective sensing layer. Analysis of the distribution and chemical bonds of these hydrophobic silica nanoparticles showed that numerous C-F bonds (which are hydrophobic) were found on the surface of the sensitive layer, which effectively blocked the adsorption of water molecules onto the ZnO NWs. This new sensing layer design minimizes the influence of humidity on the ZnO NW-based UV sensor within the relative humidity range of 10–70%. The sensor showed a UV sensitivity of 9.53 ppm (mW/cm2)−1, with high linearity (R2value of 0.99904), small hysteresis (<1.65%) and good repeatability. This work solves the long-term dilemma of ZnO NW-based sensors, which are often sensitive to humidity changes.
Emergence of changing Central-Pacific and Eastern-Pacific El Niño-Southern Oscillation in a warming climate
Authors: Geng Tao , Cai Wenju , Wu Lixin , Santoso Agus , Wang Guojian , Jing Zhao , Gan Bolan , Yang Yun , Li Shujun , Wang Shengpeng , Chen Zhaohui , McPhaden Michael J.
Published: November 2022

El Niño-Southern Oscillation (ENSO) features strong warm events in the eastern equatorial Pacific (EP), or mild warm and strong cold events in the central Pacific (CP), with distinct impacts on global climates. Under transient greenhouse warming, models project increased sea surface temperature (SST) variability of both ENSO regimes, but the timing of emergence out of internal variability remains unknown for either regime. Here we find increased EP-ENSO SST variability emerging by around 2030 ± 6, more than a decade earlier than that of CP-ENSO, and approximately four decades earlier than that previously suggested without separating the two regimes. The earlier EP-ENSO emergence results from a stronger increase in EP-ENSO rainfall response, which boosts the signal of increased SST variability, and is enhanced by ENSO non-linear atmospheric feedback. Thus, increased ENSO SST variability under greenhouse warming is likely to emerge first in the eastern than central Pacific, and decades earlier than previously anticipated.
Mode of delivery modulates the intestinal microbiota and impacts the response to vaccination
Authors: de Koff Emma M. , van Baarle Debbie , van Houten Marlies A. , Reyman Marta , Berbers Guy A. M. , van den Ham Femke , Chu Mei Ling J. N. , Sanders Elisabeth A. M. , Bogaert Debby , Fuentes Susana
Published: November 2022

The gut microbiota in early life, when critical immune maturation takes place, may influence the immunogenicity of childhood vaccinations. Here we assess the association between mode of delivery, gut microbiota development in the first year of life, and mucosal antigen-specific antibody responses against pneumococcal vaccination in 101 infants at age 12 months and against meningococcal vaccination in 66 infants at age 18 months. Birth by vaginal delivery is associated with higher antibody responses against both vaccines. Relative abundances of vaginal birth-associated Bifidobacterium and Escherichia coli in the first weeks of life are positively associated with anti-pneumococcal antibody responses, and relative abundance of E. coli in the same period is also positively associated with anti-meningococcal antibody responses. In this study, we show that mode of delivery-induced microbiota profiles of the gut are associated with subsequent antibody responses to routine childhood vaccines.
Mucosal TLR2-activating protein-based vaccination induces potent pulmonary immunity and protection against SARS-CoV-2 in mice
Authors: Ashhurst Anneliese S. , Johansen Matt D. , Maxwell Joshua W. C. , Stockdale Skye , Ashley Caroline L. , Aggarwal Anupriya , Siddiquee Rezwan , Miemczyk Stefan , Nguyen Duc H. , Mackay Joel P. , Counoupas Claudio , Byrne Scott N. , Turville Stuart , Steain Megan , Triccas James A. , Hansbro Philip M. , Payne Richard J. , Britton Warwick J.
Published: November 2022

Current vaccines against SARS-CoV-2 substantially reduce mortality, but protection against infection is less effective. Enhancing immunity in the respiratory tract, via mucosal vaccination, may provide protection against infection and minimise viral spread. Here, we report testing of a subunit vaccine in mice, consisting of SARS-CoV-2 Spike protein with a TLR2-stimulating adjuvant (Pam2Cys), delivered to mice parenterally or mucosally. Both routes of vaccination induce substantial neutralising antibody (nAb) titres, however, mucosal vaccination uniquely generates anti-Spike IgA, increases nAb in the serum and airways, and increases lung CD4+ T-cell responses. TLR2 is expressed by respiratory epithelia and immune cells. Using TLR2 deficient chimeric mice, we determine that TLR2 expression in either compartment facilitates early innate responses to mucosal vaccination. By contrast, TLR2 on hematopoietic cells is essential for optimal lung-localised, antigen-specific responses. In K18-hACE2 mice, vaccination provides complete protection against disease and sterilising lung immunity against SARS-CoV-2, with a short-term non-specific protective effect from mucosal Pam2Cys alone. These data support mucosal vaccination as a strategy to improve protection in the respiratory tract against SARS-CoV-2 and other respiratory viruses.
Cycles of Andean mountain building archived in the Amazon Fan
Authors: Mason Cody C. , Romans Brian W. , Patterson Molly O. , Stockli Daniel F. , Fildani Andrea
Published: November 2022

Cordilleran orogenic systems have complex, polycyclic magmatic and deformation histories, and the timescales and mechanisms of episodic orogenesis are still debated. Here, we show that detrital zircons (DZs) in terrigenous sediment from the late Pleistocene Amazon Fan, found at the terminus of the continent-scale Amazon River-fan system, record multiple, distinct modes of U-Pb crystallization ages and U-Th/He (ZHe) cooling ages that correlate to known South American magmatic and tectonic events. The youngest ZHe ages delineate two recent phases of Andean orogenesis; one in the Late Cretaceous – Paleogene, and another in the Miocene. Frequency analyses of the deep-time Phanerozoic record of DZ U-Pb and ZHe ages demonstrate a strong 72 Myr period in magmatic events, and 92 Myr and 57 Myr periods in crustal cooling. We interpret these results as evidence of changes in upper and lower plate coupling, associated with multiple episodes of magmatism and crustal deformation along the subduction-dominated western margin of South America.
Structure of the reduced microsporidian proteasome bound by PI31-like peptides in dormant spores
Authors: Jespersen Nathan , Ehrenbolger Kai , Winiger Rahel R. , Svedberg Dennis , Vossbrinck Charles R. , Barandun Jonas
Published: November 2022

Proteasomes play an essential role in the life cycle of intracellular pathogens with extracellular stages by ensuring proteostasis in environments with limited resources. In microsporidia, divergent parasites with extraordinarily streamlined genomes, the proteasome complexity and structure are unknown, which limits our understanding of how these unique pathogens adapt and compact essential eukaryotic complexes. We present cryo-electron microscopy structures of the microsporidian 20S and 26S proteasome isolated from dormant or germinated Vairimorpha necatrix spores. The discovery of PI31-like peptides, known to inhibit proteasome activity, bound simultaneously to all six active sites within the central cavity of the dormant spore proteasome, suggests reduced activity in the environmental stage. In contrast, the absence of the PI31-like peptides and the existence of 26S particles post-germination in the presence of ATP indicates that proteasomes are reactivated in nutrient-rich conditions. Structural and phylogenetic analyses reveal that microsporidian proteasomes have undergone extensive reductive evolution, lost at least two regulatory proteins, and compacted nearly every subunit. The highly derived structure of the microsporidian proteasome, and the minimized version of PI31 presented here, reinforce the feasibility of the development of specific inhibitors and provide insight into the unique evolution and biology of these medically and economically important pathogens.
Lithium hexamethyldisilazide as electrolyte additive for efficient cycling of high-voltage non-aqueous lithium metal batteries
Authors: Zhang Danfeng , Liu Ming , Ma Jiabin , Yang Ke , Chen Zhen , Li Kaikai , Zhang Chen , Wei Yinping , Zhou Min , Wang Peng , He Yuanbiao , Lv Wei , Yang Quan-Hong , Kang Feiyu , He Yan-Bing
Published: November 2022

High-voltage lithium metal batteries suffer from poor cycling stability caused by the detrimental effect on the cathode of the water moisture present in the non-aqueous liquid electrolyte solution, especially at high operating temperatures (e.g., ≥60 °C). To circumvent this issue, here we report lithium hexamethyldisilazide (LiHMDS) as an electrolyte additive. We demonstrate that the addition of a 0.6 wt% of LiHMDS in a typical fluorine-containing carbonate-based non-aqueous electrolyte solution enables a stable Li||LiNi0.8Co0.1Mn0.1O2 (NCM811) coin cell operation up to 1000 or 500 cycles applying a high cut-off cell voltage of 4.5 V in the 25 °C−60 °C temperature range. The LiHMDS acts as a scavenger for hydrofluoric acid and water and facilitates the formation of an (electro)chemical robust cathode|electrolyte interphase (CEI). The LiHMDS-derived CEI prevents the Ni dissolution of NCM811, mitigates the irreversible phase transformation from layered structure to rock-salt phase and suppresses the side reactions with the electrolyte solution.
Anti-Ad26 humoral immunity does not compromise SARS-COV-2 neutralizing antibody responses following Gam-COVID-Vac booster vaccination
Authors: Byazrova Maria G. , Astakhova Ekaterina A. , Minnegalieva Aygul R. , Sukhova Maria M. , Mikhailov Artem A. , Prilipov Alexey G. , Gorchakov Andrey A. , Filatov Alexander V.
Published: November 2022

Replication-incompetent adenoviral vectors have been extensively used as a platform for vaccine design, with at least four anti-COVID-19 vaccines authorized to date. These vaccines elicit neutralizing antibody responses directed against SARS-CoV-2 Spike protein and confer significant level of protection against SARS-CoV-2 infection. Immunization with adenovirus-vectored vaccines is known to be accompanied by the production of anti-vector antibodies, which may translate into reduced efficacy of booster or repeated rounds of revaccination. Here, we used blood samples from patients who received an adenovirus-based Gam-COVID-Vac vaccine to address the question of whether anti-vector antibodies may influence the magnitude of SARS-CoV-2-specific humoral response after booster vaccination. We observed that rAd26-based prime vaccination with Gam-COVID-Vac induced the development of Ad26-neutralizing antibodies, which persisted in circulation for at least 9 months. Our analysis further indicates that high pre-boost Ad26 neutralizing antibody titers do not appear to affect the humoral immunogenicity of the Gam-COVID-Vac boost. The titers of anti-SARS-CoV-2 RBD IgGs and antibodies, which neutralized both the wild type and the circulating variants of concern of SARS-CoV-2 such as Delta and Omicron, were independent of the pre-boost levels of Ad26-neutralizing antibodies. Thus, our results support the development of repeated immunization schedule with adenovirus-based COVID-19 vaccines.
Synthetic control of the surface area in nickel cobalt oxide for glucose detection via additive-assisted wet chemical method
Authors: Jang Kyu-bong , Park Kyoung Ryeol , Mo Chan Bin , Kim Seongtak , Jeon Jaeeun , Lim Sung-chul , Ahn Chisung , Han HyukSu , Kim Dongju , Lee Seung Hwan , Kim Kang Min , Mhin Sungwook
Published: November 2022

We investigated the effect of specific surface area on the electrochemical properties of NiCo2O4 (NCO) for glucose detection. NCO nanomaterials with controlled specific surface areas were prepared by additive-assisted hydrothermal synthesis, and self-assembled nanostructures with urchin-, pine-needle-, tremella-, and flower-like morphologies were obtained. The novelty of this method is the systematic control of chemical reaction routes assisted by the addition of different additives during synthesis, which results in the spontaneous formation of various morphologies without any difference in the crystal structure and chemical states of the constituent elements. Such morphological control of NCO nanomaterials leads to considerable changes in the electrochemical performance for glucose detection. Combined with materials characterization, the relationship between the specific surface area and the electrochemical performance is discussed for glucose detection. This work can provide scientific insights for tailoring the surface area of nanostructures, which determines their functionality for potential applications in glucose biosensors.
Lithology and disturbance drive cavefish and cave crayfish occurrence in the Ozark Highlands ecoregion
Authors: Mouser Joshua B. , Brewer Shannon K. , Niemiller Matthew L. , Mollenhauer Robert , Van Den Bussche Ronald A.
Published: November 2022

Diverse communities of groundwater-dwelling organisms (i.e., stygobionts) are important for human wellbeing; however, we lack an understanding of the factors driving their distributions, making it difficult to protect many at-risk species. Therefore, our study objective was to determine the landscape factors related to the occurrence of cavefishes and cave crayfishes in the Ozark Highlands ecoregion, USA. We sampled cavefishes and cave crayfishes at 61 sampling units using both visual and environmental DNA surveys. We then modeled occurrence probability in relation to lithology and human disturbance while accounting for imperfect detection. Our results indicated that occurrence probability of cave crayfishes was negatively associated with human disturbance, whereas there was a weak positive relationship between cavefish occurrence and disturbance. Both cavefishes and cave crayfishes were more likely to occur in limestone rather than dolostone lithology. Our results indicate structuring factors are related to the distribution of these taxa, but with human disturbance as a prevalent modifier of distributions for cave crayfishes. Limiting human alteration near karst features may be warranted to promote the persistence of some stygobionts. Moreover, our results indicate current sampling efforts are inadequate to detect cryptic species; therefore, expanding sampling may be needed to develop effective conservation actions.
Mutagenesis alters sperm swimming velocity in Astyanax cave fish
Authors: Borowsky Richard , Chen Haining
Published: November 2022

We investigated the hypothesis that intra ejaculate sperm competition screens against the transmission of deleterious alleles, including new mutants, from male parent to offspring. Recent investigations have established that sperm haploid genotypes can have major effects on sperm traits such as cellular robustness, longevity, and fertilization success. However, there is no evidence that new mutations can meaningfully affect sperm phenotypes. We tested this directly by comparing sperm from mutagenized and non-mutagenized control males in Astyanax fish. We used N-ethyl-N-nitrosourea (ENU) to induce single base substitutions in spermatogonial stem cells. We looked at swimming velocity, an important factor contributing to fertilization success, and flagellar length. Variability in swimming velocity was significantly higher in sperm from mutagenized males than in control sperm, reflecting their increased allelic diversity. In contrast, flagellar length, which is fixed during diploid stages of spermatogenesis, was unaffected by ENU treatment. We briefly discuss the implications of intra-ejaculate screening for maintenance of anisogamy and for outcomes of assisted reproductive technology.
Longitudinal impact of COVID-19 pandemic on mental health of children in the ABCD study cohort
Authors: Hamatani Sayo , Hiraoka Daiki , Makita Kai , Tomoda Akemi , Mizuno Yoshifumi
Published: November 2022

A large longitudinal study on the impact of the COVID-19 pandemic on mental health in children is limited. This large-scale longitudinal observational study examines the pandemic’s effects on children’s mental health while considering the effects of parental care styles. The Adolescent Brain Cognitive Development Study is a large-scale, longitudinal multicenter study in the United States. Of the 11,875 children aged 9–12 years in its database, 4702 subjects were selected for this study. The child behavior checklist and parental monitoring questionnaire (PMQ) were used to assess children’s mental health and parental support styles, respectively. Data collected before and during the pandemic were compared. Withdrawn/depressed and attention problems significantly worsened during compared to before the COVID-19 pandemic (p < 0.001, withdrawn/depressed; 53.4 ± 5.7 to 53.7 ± 5.9, attention problems; 53.4 ± 5.4 to 53.6 ± 5.6). However, the T scores are in the normal range both before and during the crisis. Simple slope analysis found withdrawn/depressed problems and aggressive behavior worsened when the PMQ was 1 SD below the mean, and rule-breaking behavior was improved when the PMQ was 1 SD above the mean. While the COVID-19 pandemic exacerbated children’s depressive symptoms and attention issues, the effects may be minor. Additionally, parental involvement serve as a protective factor for the child’s mental health even during the pandemic.
Restricted cafeteria feeding and treadmill exercise improved body composition, metabolic profile and exploratory behavior in obese male rats
Authors: Alvarez-Monell Adam , Subias-Gusils Alex , Mariné-Casadó Roger , Belda Xavier , Gagliano Humberto , Pozo Oscar J. , Boqué Noemí , Caimari Antoni , Armario Antonio , Solanas Montserrat , Escorihuela Rosa M.
Published: November 2022

The aim of this study was to evaluate, in male Long-Evans rats, whether a restricted-cafeteria diet (CAFR), based on a 30% calorie restriction vs continuous ad libitum cafeteria (CAF) fed animals, administered alone or in combination with moderate treadmill exercise (12 m/min, 35 min, 5 days/week for 8 weeks), was able to ameliorate obesity and the associated risk factors induced by CAF feeding for 18 weeks and to examine the changes in circadian locomotor activity, hypothalamic–pituitary–adrenal (HPA) axis functionality, and stress response elicited by this dietary pattern. In addition to the expected increase in body weight and adiposity, and the development of metabolic dysregulations compatible with Metabolic Syndrome, CAF intake resulted in a sedentary profile assessed by the home-cage activity test, reduced baseline HPA axis activity through decreased corticosterone levels, and boosted exploratory behavior. Both CAFR alone and in combination with exercise reduced abdominal adiposity and hypercholesterolemia compared to CAF. Exercise increased baseline locomotor activity in the home-cage in all dietary groups, boosted exploratory behavior in STD and CAF, partially decreased anxiety-like behavior in CAF and CAFR, but did not affect HPA axis-related parameters.
The placebo effect shortens movement time in goal-directed movements
Authors: Fiorio Mirta , Villa-Sánchez Bernardo , Rossignati Filippo , Emadi Andani Mehran
Published: November 2022

The placebo effect is a powerful psychobiological phenomenon whereby a positive outcome follows the administration of an inert treatment thought to be effective. Growing evidence shows that the placebo effect extends beyond the healing context, affecting also motor performance. Here we explored the placebo effect on the control of goal-directed movement, a fundamental function in many daily activities. Twenty-four healthy volunteers performed upper-limb movements toward a target at different indexes of difficulty in two conditions: in the placebo condition, an electrical device (inert) was applied to the right forearm together with verbal information about its positive effects in improving movement precision; in the control condition, the same device was applied along with verbal information about its neutral effects on performance. Interestingly, we found shorter movement time in the placebo compared to the control condition. Moreover, subjective perception of fatigability was reduced in the placebo compared to the control condition. These findings indicate that the placebo effect can improve the execution of goal-directed movements, thus adding new evidence to the placebo effect in the motor domain. This study could inspire future applications to improve upper-limb movements or in clinical settings for patients with motor deficits.
Protective effect of Tisochrysis lutea on dry eye syndrome via NF-κB inhibition
Authors: Hong Sung-Chul , Yu Hyung Seok , Kim Jin-Woo , Lee Eun Ha , Pan Cheol-Ho , Hong Kwang Won , Kim Jin-Chul
Published: November 2022

Dry eye syndrome (DES) affects the cornea, causes pain and hypersensitivity to light. Although inflammation and endoplasmic reticulum stress are known to be involved, the detailed mechanisms remain unknown. DES is characterized by a decrease in corneal thickness, tear volume, and lacrimal gland size, and damage to corneal cells. Tisochrysis lutea is a microalga that has been shown to reduce immune factors. Therefore, we hypothesized that T. lutea could ameliorate DES. We investigated the role of T. lutea in scopolamine-induced DES in BALB/c mice. Oral administration of T. lutea increased corneal thickness, tear volume, and size of the corneal cells, and reduced damage to the corneal cells. Furthermore, treatment of ARPE-19 human retinal pigmented epithelial cells with T. lutea reduced expression of the inflammatory factor, NF-κB, MAPK, and AKT. T. lutea may be used therapeutically to reduce the symptoms of DES.
Causes and management of persistent septal deviation after septoplasty
Authors: Lee Dong-Joo , Jo Hyunju , Kwon Ha-Nee , Park Ji-Hwan , Kim Sung-Dong , Cho Kyu-Sup
Published: November 2022

Septoplasty is one of the most common otolaryngological surgical procedures. The causes of persistent septal deviation after primary septoplasty vary. The purpose of this study was to identify factors associated with failure of primary septoplasty, operative techniques that correct residual septal deviation, and surgical outcomes. Seventy-four adults who underwent revision septoplasty to treat persistent septal deviations were enrolled. The level of hospital in which primary septoplasty was performed, type of septal deviation, septal portion exhibiting persistent deviation, and techniques used to correct the deviation were evaluated. Outcomes were measured subjectively using a visual analog scale (VAS), and objectively using acoustic rhinometry. The first septoplasties were usually performed in primary and secondary hospitals. C-shaped deviations were more common than S-shaped ones in both the anteroposterior and cephalocaudal dimensions. The most common region of persistent septal deviation was the caudal septum (44.6%), followed by multiple sites (20.3%). The corrective techniques included excision of the remnant deviated portion (70.3%), septal cartilage traction suturing (27.0%), spreader grafting (13.5%), and cross-suturing (6.8%). The VAS score improved significantly 6 months after surgery. The minimal cross-sectional area and nasal cavity volume of the convex side increased significantly after revision septoplasty. Patients who underwent septoplasty in primary and secondary hospitals were more likely to require revision septoplasty. The caudal septum was the most common site of persistent septal deviation. Careful preoperative evaluation of the caudal septal deviation and selection of an appropriate surgical technique may reduce the need for revision septoplasty.
Loss of participation among evacuees aged 20–37 years in the disaster cohort study after the Great East Japan Earthquake
Authors: Yamamoto Kana , Takita Morihito , Kami Masahiro , Tani Yuta , Yamamoto Chika , Zhao Tianchen , Ohira Tetsuya , Maeda Masaharu , Yasumura Seiji , Sakai Akira , Hosoya Mitsuaki , Okazaki Kanako , Yabe Hirooki , Tsubokura Masaharu , Shimabukuro Michio , Ohto Hitoshi , Kamiya Kenji
Published: November 2022

The present study aimed to clarify the characteristics of young evacuees who had missed the Comprehensive Health Check of the Fukushima Health Management Survey (FHMS) after the Great East Japan Earthquake in 2011. The FHMS has been conducted as a prospective cohort study to evaluate the health status of evacuees annually after the great earthquake in 2011. This study focused on the annual participation rate in the Comprehensive Health Check of evacuees aged between 20 and 37 years in 2011 who evacuated due to the Fukushima Daiichi Nuclear Power Plant accident. The characteristics of subjects who did not participate after the second survey year were identified with a multivariate logistic regression model. The participation rate was estimated at 26.6% (9720 among 36,502 residents) and 15.6% (5691 residents) in 2011 and 2012, respectively. The logistic regression model revealed the following characteristics at baseline as independent predictors of non-participation after the second year of the survey: age ≤ 24 years (adjusted odds ratio 2.11, 95% CI 1.84–2.42), 25–29 years of age (1.28, 1.13–1.45), men (1.52, 1.38–1.69), evacuation outside the municipality but within Fukushima prefecture (1.54, 1.40–1.70), evacuation outside the Fukushima prefecture (1.40, 1.21–1.63), anemia (1.23, 1.06–1.43), smoking habit (1.34, 1.21–1.48), and drinking habit (1.20, 1.09–1.32). A medical history of heart disease showed opposite odds ratios, which indicate the association with continuous participation (0.43, 0.26–0.72, respectively). We observed deteriorated participation in the prospective study of the Comprehensive Health Check of the FHMS among evacuees of a younger age group, men, those evacuated outside their municipalities, and those with history of anemia, smoking and drinking habits. Hence, the cohort study may have missed certain population groups with worse health behaviors. Thus, it is necessary to consider various measures to increase the participation rate in the disaster cohort study to understand the long-term health effects of disasters on younger residents in evacuation zones.
A qualitative study on the experience of stigma for Chinese parents of children with autism spectrum disorder
Authors: Ng Catalina Sau Man , Ng Sally Sui Ling
Published: November 2022

Experiencing stigma related to having a child with autism spectrum disorder (ASD) can be difficult and is detrimental to parent well-being. Since the research on stigmatized experiences among parents of children with ASD in non-Western communities is limited, this qualitative study examined the experiences, reactions and impacts of stigma on parents of children with ASD in Hong Kong. In-depth interviews were conducted with 54 Chinese parents/caregivers of children with ASD aged between 35 and 73 years old. Data were analyzed using an inductive approach. The participants reported stigma which stemmed from negative labelling of their children by schools and healthcare professionals, bullying by peers, stereotypes of ASD and stigma linked to autistic children’s behavior in the community. The reactions of participants towards stigmatization were classified into internalizing reactions including apologizing, ignoring and concealing ASD and externalizing reactions such as fighting back. The participants also reported impacts of stigma on both personal and emotional levels. The results point to the urgent need for the government to allocate resources and make concerted efforts to reduce stigma by educating the community to foster more positive attitudes towards individuals with ASD and offer support and counselling services to parents.
TNF-alpha inhibitors biosimilar use in France: a nationwide population-based study using the French National Health Data System
Authors: Jourdain Hugo , Hoisnard Léa , Sbidian Emilie , Zureik Mahmoud
Published: November 2022

TNF-alpha inhibitors have revolutionized the therapeutic care in chronic inflammatory diseases. Several biosimilar products were commercialized at their patent expiry, substantially decreasing the cost of treatment. This longitudinal descriptive study aimed at assessing infliximab, etanercept and adalimumab biosimilar penetration rates using data of the French National Health Data System. A total of 207,118 new or prevalent users from the date of first biosimilar commercialization in France (respectively January 2015, May 2016 and October 2018) were included in the study and followed until September 30, 2021. Biosimilars represented respectively 78%, 46% and 53% of the overall initiations, and 94%, 66% and 60% last year’s initiations. A total of 46%, 19% and 17% of originator product prevalent users switched for a biosimilar during the follow-up. Biosimilar penetration rate was much higher for infliximab than for its counterparts, due to its hospital delivery modality. Biosimilar initiation and originator-to-biosimilar switch tended to be observed more in rheumatology than in the other specialties. Biosimilar use was mostly consistent across patient socio-demographic characteristics. Biosimilar initiation rate increased rapidly from their market arrival and originator-to-biosimilar switch rate remained moderate, highlighting the need and usefulness of political action and biosimilar use tracking.
A genotyping by sequencing approach can disclose Apis mellifera population genomic information contained in honey environmental DNA
Authors: Bovo Samuele , Utzeri Valerio Joe , Ribani Anisa , Taurisano Valeria , Schiavo Giuseppina , Fontanesi Luca
Published: November 2022

Awareness has been raised over the last years on the genetic integrity of autochthonous honey bee subspecies. Genomic tools available in Apis mellifera can make it possible to measure this information by targeting individual honey bee DNA. Honey contains DNA traces from all organisms that contributed or were involved in its production steps, including the honey bees of the colony. In this study, we designed and tested a genotyping by sequencing (GBS) assay to analyse single nucleotide polymorphisms (SNPs) of A. mellifera nuclear genome using environmental DNA extracted from honey. A total of 121 SNPs (97 SNPs informative for honey bee subspecies identification and 24 SNPs associated with relevant traits of the colonies) were used in the assay to genotype honey DNA, which derives from thousands of honey bees. Results were integrated with information derived from previous studies and whole genome resequencing datasets. This GBS method is highly reliable in estimating honey bee SNP allele frequencies of the whole colony from which the honey derived. This assay can be used to identify the honey bee subspecies of the colony that produced the honey and, in turn, to authenticate the entomological origin of the honey.
Crystal structure of semi-synthetic obelin-v after calcium induced bioluminescence implies coelenteramine as the main reaction product
Authors: Natashin Pavel V. , Eremeeva Elena V. , Shevtsov Mikhail B. , Kovaleva Margarita I. , Bukhdruker Sergey S. , Dmitrieva Daria A. , Gulnov Dmitry V. , Nemtseva Elena V. , Gordeliy Valentin I. , Mishin Alexey V. , Borshchevskiy Valentin I. , Vysotski Eugene S.
Published: November 2022

Coelenterazine-v (CTZ-v), a synthetic vinylene-bridged π-extended derivative, is able to significantly alter bioluminescence spectra of different CTZ-dependent luciferases and photoproteins by shifting them towards longer wavelengths. However, Ca2+-regulated photoproteins activated with CTZ-v display very low bioluminescence activities that hampers its usage as a substrate of photoprotein bioluminescence. Here, we report the crystal structure of semi-synthetic Ca2+-discharged obelin-v bound with the reaction product determined at 2.1 Å resolution. Comparison of the crystal structure of Ca2+-discharged obelin-v with those of other obelins before and after bioluminescence reaction reveals no considerable changes in the overall structure. However, the drastic changes in CTZ-binding cavity are observed owing to the completely different reaction product, coelenteramine-v (CTM-v). Since CTM-v is certainly the main product of obelin-v bioluminescence and is considered to be a product of the “dark” pathway of dioxetanone intermediate decomposition, it explains the low bioluminescence activity of obelin and apparently of other photoproteins with CTZ-v.
Association between fractional amplitude of low-frequency fluctuation (fALFF) and facial emotion recognition ability in first-episode schizophrenia patients: a fMRI study
Authors: Kuang Qijie , Zhou Sumiao , Li Haijing , Mi Lin , Zheng Yingjun , She Shenglin
Published: November 2022

It was still unclear that the correlation between the resting-state intrinsic activity in brain regions and facial emotion recognition (FER) ability in patients with first-episode schizophrenia (FSZ). Our aim was to analyse the correlation between the fractional amplitude of low-frequency fluctuation (fALFF) and FER ability in FSZ patients. A total of 28 patients with FSZ and 33 healthy controls (HCs) completed visual search tasks for FER ability. Regions of interest (ROIs) related to facial emotion were obtained from a previous meta-analysis. Pearson correlation analysis was performed to understand the correlation between fALFF and FER ability. Our results indicated that the patients performed worse than the HCs in the accuracy performances of happy FER and fearful FER. The previous meta-analysis results showed that the brain regions related to FER included the bilateral amygdala (AMY)/hippocampus (HIP), right fusiform gyrus (FFG), and right supplementary motor area (SMA). Partial correlation analysis showed that the fALFF of the right FFG was associated with high-load fearful FER accuracy (r = − 0.60, p = 0.004). Our study indicated that FER ability is correlated with resting-state intrinsic activity in brain regions related to facial emotion, which may provide a reference for the study of FER deficiency in schizophrenia.
Trifloxystrobin blocks the growth of Theileria parasites and is a promising drug to treat Buparvaquone resistance
Authors: Villares Marie , Lourenço Nelly , Berthelet Jeremy , Lamotte Suzanne , Regad Leslie , Medjkane Souhila , Prina Eric , Rodrigues-Lima Fernando , Späth Gerald F. , Weitzman Jonathan B.
Published: November 2022

Theileria parasites are responsible for devastating cattle diseases, causing major economic losses across Africa and Asia. Theileria spp. stand apart from other apicomplexa parasites by their ability to transform host leukocytes into immortalized, hyperproliferating, invasive cells that rapidly kill infected animals. The emergence of resistance to the theilericidal drug Buparvaquone raises the need for new anti-Theileria drugs. We developed a microscopy-based screen to reposition drugs from the open-access Medicines for Malaria Venture (MMV) Pathogen Box. We show that Trifloxystrobin (MMV688754) selectively kills lymphocytes or macrophages infected with Theileria annulata or Theileria parva parasites. Trifloxystrobin treatment reduced parasite load in vitro as effectively as Buparvaquone, with similar effects on host gene expression, cell proliferation and cell cycle. Trifloxystrobin also inhibited parasite differentiation to merozoites (merogony). Trifloxystrobin inhibition of parasite survival is independent of the parasite TaPin1 prolyl isomerase pathway. Furthermore, modeling studies predicted that Trifloxystrobin and Buparvaquone could interact distinctly with parasite Cytochrome B and we show that Trifloxystrobin was still effective against Buparvaquone-resistant cells harboring TaCytB mutations. Our study suggests that Trifloxystrobin could provide an effective alternative to Buparvaquone treatment and represents a promising candidate for future drug development against Theileria spp.
A rhodamine based chemodosimeter for the detection of Group 13 metal ions
Authors: Ghosh Sneha , Roy Partha
Published: November 2022

Group 13 cations induce hydrolysis of a rhodamine based dye to cause a sharp color change from colorless to pink and a high increment in fluorescence.
Recent developments in oxide ion conductors: focusing on Dion–Jacobson phases
Authors: Zhang Wenrui , Yashima Masatomo
Published: November 2022

We present recent developments in oxide ion conductors focusing on Dion–Jacobson phases, and demonstrate how the information gleaned from these studies can be applied to the design of novel oxide-ion conductors.
Experimental and computational studies on pseudotetrahedral nickel(ii)-(S or R)-dihalogen-salicylaldiminates with Δ- or Λ-chirality induction at-metal
Authors: Saadati Arezoo , Amiri Rudbari Hadi , Aryaeifar Mahnaz , Blacque Olivier , Correia Isabel , Islam Mohammad Khairul , Woschko Dennis , Haj Hassani Sohi Takin , Janiak Christoph , Enamullah Mohammed
Published: November 2022

Synthesis of pseudotetrahedral bis[(S or R)-N-1-(phenyl)ethyl-(2,4-dihalogen-salicylaldiminato-κ2N,O)]-Δ/Λ-nickel(ii), Δ/Λ-Ni(S or R)L1–3 with Δ- or Λ-chirality induction at-metal.
Fused aza-heterocyclic ligands: expanding the MOF chemist's toolbox
Authors: Wood Oskar G. , Hawes Chris S.
Published: November 2022

Fused azolate ligands are hydrolytically-stable linkers for metal–organic frameworks. Their unique geometries and capacity for functionalisation have opened new pathways at the convergence of simple N-heterocycles and biologically relevant purines.
Effect of atmospheric water vapor on independent-parallel thermal dehydration of a compacted composite of an inorganic hydrate: sodium carbonate monohydrate grains comprising crystalline particles and a matrix
Authors: Zushi Yuto , Iwasaki Shun , Koga Nobuyoshi
Published: November 2022

The universal kinetic descriptions over different atmospheric water vapors provide further insights into the kinetics of the thermal dehydration of sodium carbonate monohydrate grains as a compacted composite.
Hollow TiO2/SiO2 composite microspheres through reactive assembly across immiscible liquid interfaces
Authors: Bahadur Jitendra , Prakash Jyoti , Das Avik , Sen Debasis
Published: November 2022

An immiscible interface across aqueous droplets has been utilized to achieve hollow TiO2 and TiO2/SiO2 composite microspheres which show superior photocatalytic characteristics.
Advanced plasmonic technologies for multi-scale biomedical imaging
Authors: Lin Jia-Sheng , Tian Xiang-Dong , Li Gang , Zhang Fan-Li , Wang Yan , Li Jian-Feng
Published: November 2022

Plasmonic technologies are available for multi-scale biomedical imaging ranging from micrometre to angstrom level.
Valorisation of wine wastes by de novo biosynthesis of resveratrol using a recombinant xylose-consuming industrial Saccharomyces cerevisiae strain
Authors: Costa Carlos E. , Romaní Aloia , Møller-Hansen Iben , Teixeira José A. , Borodina Irina , Domingues Lucília
Published: November 2022

A recombinant S. cerevisiae strain was engineered to produce resveratrol from many carbon sources, including xylose, which was used for the synthesis of resveratrol from different wine wastes like vine pruning residue, grape must and wine lees.
The active ruthenium (101) crystal plane selectively exposed byin situmetal hyperaccumulation on a living plant for overall water splitting
Authors: Tang Sirui , Liu Zirui , Qiu Feng , Liu Qingju , Mao Yong , Zhang Longzhou
Published: November 2022

In situhyperaccumulation on biomass makes ruthenium nanoparticles expose the typical (101) plane for efficient electrocatalytic overall water splitting.
Micromagnetic and morphological characterization of heteropolymer human ferritin cores
Authors: Longo Thomas , Kim Steve , Srivastava Ayush K. , Hurley Lauren , Ji Kaixuan , Viescas Arthur J. , Flint Nicholas , Foucher Alexandre C. , Yates Douglas , Stach Eric A. , Bou-Abdallah Fadi , Papaefthymiou Georgia C.
Published: November 2022

The physical properties of in vitro iron-reconstituted and genetically engineered human heteropolymer ferritins were investigated.
Synthesis of a bilayered SDS/ionic liquid stabilized ferrofluid and magnetic cubic mesoporous silica using a long chain ionic liquid
Authors: Shen Jing , Wang Dongxiu , Yang Li , Wang Tongwen , Yang Qianmo , Wang Jun
Published: November 2022

Magnetic cubic mesoporous silica can be synthesized using TEOS as a silicon source and ionic liquid C16mim+ as a template.
Improved H-adsorption ability and conductivity of a Co-doped Mo2N cocatalyst for efficient photocatalytic H2 generation of g-C3N4
Authors: Lu Zhongxi , He Xudong , Jin Cheng , Jiang Haopeng , Yu Xiaohui , Sun Lijuan , Wang Weikang , Wang Lele , Liu Qinqin
Published: November 2022

Cocatalysts are usually applied in the photocatalytic water splitting process to accelerate the kinetics of the hydrogen evolution reaction (HER).
Durable CuxO/mesoporous TiO2 photocatalyst for stable and efficient hydrogen evolution
Authors: Cui Lingling , Niu Chunyao , Kang Young Soo , Caruso Rachel A. , Zhang Xiao Li
Published: November 2022

Interlayer ion-exchange and space confinement nature of layered titanate ensured successful transition to CuxO/mesoporous TiO2 photocatalysts of superior HER performance.
Reliability of printed stretchable electronics based on nano/micro materials for practical applications
Authors: Lv Jian , Thangavel Gurunathan , Lee Pooi See
Published: November 2022

The failure modes when printing stretchable electronics using nano/micro composite ink was summarized and strategies for tackling these challenges to realize reliable performances are proposed and discussed.