bluuebunny/crossref_metadata_2025 huggingface dataset:
Kajian Kelayakan Usaha Produk "TEPIS" Turkish Delight Jeruk Nipis Dengan Penambahan Sari Buah-Buahan
Authors: Aldebaran Deksa , Sa'ati Elfi Anis , Wahyudi Vritta Amroini
Published: September 2024

Soft candy merupakan camilan manis berbentuk permen jelly yang terbuat dari air dan sari buah yang banyak digemari masyarakat karena memiliki kenampakan bening serta tekstur yang kenyal. Tingginya tingkat konsumsi soft candy di Indonesia menjadi peluang usaha dengan prospek yang baik untuk dikembangkan. Salah satu produk inovasi yang berasal dari soft candy merupakan turkish delight. Peluang usaha turkish delight ini dapat diterapkan pada jenis usaha dengan skala UMKM (Usaha Mikro Kecil Menengah). Kelayakan usaha menjadi salah satu aspek penting dalam kesuksesan suatu usaha. Tujuan dilakukannya kajian ini untuk mengetahui hasil analisis kelayakan usaha pada produk ”TEPIS” Turkish Delight Jeruk Nipis yang meliputi perhitungan BEP (Break Even Point), R/C Ratio (Reveneu Cost Ratio), ROI (Return On Investment), payback periode. Berdasarkan hasil kajian yang telah dilakukan, usaha “TEPIS” Turkish Delight Jeruk Nipis menghasilkan titik BEP (Break Even Point) unit dan harga pada varian original 279,35 unit dan Rp820.866,00, varian buah naga 504,023 unit dan Rp820.866,00, varian buah anggur 227,175 unit dan Rp820.866,00, varian buah nanas 225,130 unit dan Rp820.866,00. Usaha TEPIS layak untuk dijalankan dengan hasil proyeksi R/C ratio lebih dari 1 (>1) yaitu 1,284. Usaha TEPIS layak untuk penanaman modal investor dengan proyeksi ROI (Return On Invesment) sebesar 28,48% dengan jangka waktu lama pengembalian modal selama 9,19 bulan.
PENERAPAN SISTEM PENDUKUNG KEPUTUSAN UNTUK MENGANALISA KESEHATAN ANAK DALAM UPAYA MENCEGAH GEJALA PRA DIABETES ANAK PADA TIM PKK KELURAHAN DURI KEPA KEBON JERUK JAKARTA BARAT
Authors: Fajriah Riri
Published: September 2024

Dengan berkembangnya makanan dan minuman kemasan tinggi gula di masyarakat saat ini mengakibatkan angka penderita diabetes meningkat di Indonesia. Bahkan penderita diabetes dikalangan anak dan usia balita juga meningkat. Sebagai bagian kepedulian terhadap permasalahan kesehatan yang terjadi di Indonesia Tim Kader Penggerak PKK Kelurahan Duri Kepa merasa perlu adanya upaya sosialisasi dan kontrol atau screening awal kepada masyarakat khususnya usia anak dan balita terkait kemungkinan adanya indikasi menderita penyakit diabetes agar dapat ditanggulangi lebih awal. Oleh karena itu, Kegiatan Pengabdian Kepada Masyarakat kali ini bertemakan pengajaran Sistem Pendukung Keputusan menggunakan Software Decision Oven untuk melakukan evaluasi gejala pra-diabetes pada anak dan balita dengan kriteria-kriteria gejala yang ada. Diharapkan dengan memiliki kemampuan dalam menggunakan Software Decision Oven maka para Kader Penggerak PKK di Kelurahan Duri Kepa akan lebih mengoptimalkan proses screening di masyarakat mengenai gejala penyakit diabetes khususnya pada usia balita dan anak-anak, sehingga dapat memberikan edukasi kepada para orang tua mengenai pola hidup sehat dan pemberian gizi berimbang kepada anak-anak dan balita, untuk menanggulangi gejala diabetes lebih parah nantinya. Upaya pemberdayaan para kader penggerak PKK dalam masalahan kesehatan dimasyarakat perlu didukung dengan penerapan teknologi tepat guna agar mengoptimalkan kinerja dalam pelayanan serta pemberian edukasi tentang kesehatan yang baik kepada masyarakat.
PENGEMBANGAN APLIKASI MOBILE RESERVASI BERBASIS WEB UNTUK MENINGKATKAN SOCIOPRENEUR DI WISATA GLAMPING GUBUG MARAWATI DESA SAJEN
Authors: Ramadhani Nugrahardi , Prasetyo Didit , Yudistira Alamin Rabendra , Noordyanto Naufan , Dwitasari Putri , Orta Darmawati Nurina , Kusuma Wardani Kartika , Dharmawan Yogantara S. , Jati Santoso Bagus
Published: September 2024

Peningkatan minat terhadap wisata glamping di Indonesia menuntut adanya inovasi dalam sistem reservasi yang efisien dan user-friendly. Pengabdian masyarakat ini bertujuan untuk mengembangkan aplikasi mobile reservasi berbasis web dan mensosialisasikan agar membantu meningkatkan layanan dan mengembangkan sociopreneur   di Wisata Glamping Gubug Marawati. Metode yang digunakan meliputi survei kepada pengguna aplikasi reservasi mobile dengan fokus pada demografi, preferensi fitur, pengalaman pemesanan, dan masalah teknis. Hasil menunjukkan bahwa mayoritas responden berusia 25-35 tahun dengan pendidikan minimal S1 dan memiliki pekerjaan tetap, menginginkan aplikasi yang user-friendly dan mudah diakses. Fitur pencarian informasi, pemesanan online, dan ulasan pengguna paling diminati, sementara integrasi dengan sistem pembayaran digital dan fitur notifikasi dianggap penting. Pengalaman pengguna cukup positif, namun ada keluhan terkait waktu loading dan kegagalan transaksi. Masalah teknis seperti bug dan crash juga sering ditemukan. Kesimpulan menunjukkan bahwa aplikasi mobile yang stabil, responsif, dan informatif dengan dukungan teknis non-stop sangat diperlukan untuk memenuhi kebutuhan pengguna dan mendukung tujuan Sustainable Development Goals (SDGs) dalam meningkatkan kualitas layanan wisata berbasis alam dan mendukung kewirausahaan sosial di daerah tersebut.
EDUKASI LITERASI KEUANGAN PADA SEKOLAH PROVIDENTIA
Authors: Perkasa Didin Hikmah , Purwanto Setiyo , Yuliana Lingga , Abdullah Muhammad Al Faruq , Febrian Wenny Desty
Published: September 2024

Penelitian ini bertujuan untuk mengeksplorasi tingkat pengetahuan dasar literasi keuangan di kalangan siswa Sekolah Menengah Atas (SMA). Literasi keuangan merupakan kemampuan untuk memahami dan mengelola keuangan pribadi secara efektif, termasuk pengetahuan tentang tabungan, investasi, pengelolaan utang, dan perencanaan keuangan. Studi ini menggunakan metode survei dengan melibatkan Kurang Lebih 50 siswa dari Sekolah SMA Providentia di wilayah Jakarta Barat. Data dikumpulkan melalui penyampaian materi yang mengukur pengetahuan dasar keuangan, sikap terhadap pengelolaan keuangan, dan perilaku keuangan siswa. Hasil penelitian menunjukkan bahwa tingkat literasi keuangan siswa SMA secara umum masih rendah. Banyak siswa yang belum memahami konsep dasar seperti bunga majemuk, diversifikasi investasi, dan pentingnya menabung. Faktor-faktor seperti latar belakang pendidikan orang tua, akses terhadap informasi keuangan, dan program pendidikan keuangan di sekolah berpengaruh signifikan terhadap tingkat literasi keuangan siswa. Penelitian ini mengindikasikan perlunya peningkatan pendidikan literasi keuangan di kalangan siswa SMA melalui kurikulum yang lebih komprehensif dan praktis. Penerapan program pendidikan keuangan yang melibatkan simulasi, praktik langsung, dan pengajaran dari para ahli di bidang keuangan dapat membantu meningkatkan pemahaman dan keterampilan keuangan siswa. Dengan demikian, siswa diharapkan dapat membuat keputusan keuangan yang lebih bijaksana di masa depan dan menghindari masalah keuangan yang dapat menghambat kesejahteraan mereka.
Microglia Mediate Metabolic Dysfunction From Common Air Pollutants Through NF-κB Signaling
Authors: Debarba Lucas K. , Jayarathne Hashan S.M. , Stilgenbauer Lukas , dos Santos Ana L. Terra , Koshko Lisa , Scofield Sydney , Sullivan Ryan , Mandal Abhijit , Klueh Ulrike , Sadagurski Marianna
Published: September 2024

The prevalence of type 2 diabetes (T2D) poses a significant health challenge, yet the contribution of air pollutants to T2D epidemics remains under-studied. Several studies demonstrated a correlation between exposure to volatile organic compounds (VOCs) in indoor/outdoor environments and T2D. Here, we conducted the first meta-analysis, establishing a robust association between exposure to benzene, a prevalent airborne VOC, and insulin resistance in humans across all ages. We used a controlled benzene exposure system, continuous glucose monitoring approach, and indirect calorimetry in mice, to investigate the underlying mechanisms. Following exposure, disruptions in energy homeostasis, accompanied by modifications in the hypothalamic transcriptome and alterations in insulin and immune signaling, were observed exclusively in males, leading to a surge in blood glucose levels. In agreement, RNA sequencing of microglia revealed increased expression of genes associated with immune response and NF-κB signaling. Selective ablation of IKKβ in immune cells (Cx3cr1GFPΔIKK) or exclusively in microglia (Tmem119ERΔIKK) in adult mice alleviated benzene-induced gliosis, restored energy homeostasis and hypothalamic gene expression, and protected against hyperglycemia. We conclude that the microglial NF-κB pathway plays a critical role in chemical-induced metabolic disturbances, revealing a vital pathophysiological mechanism linking exposure to airborne toxicants and the onset of metabolic diseases.

Article Highlights
Microglia Mediate Metabolic Dysfunction from Common Air Pollutants through NF-κB Signaling
Authors: K. Debarba Lucas , S.M. Jayarathne Hashan , Stilgenbauer Lukas , L.Terra dos Santos Ana , Koshko Lisa , Scofield Sydney , Sullivan Ryan , Mandal Abhijit , Klueh Ulrike , Sadagurski Marianna
Published: September 2024

Abstract

The prevalence of Type 2 Diabetes (T2D) poses a significant health challenge yet the contribution of air pollutants to T2D epidemics remains understudied. Several studies demonstrated a correlation between exposure to volatile organic compounds (VOCs) in indoor/outdoor environments, and T2D. Here, we conducted the first meta-analysis, establishing a robust association between exposure to benzene, a prevalent airborne VOC, and insulin resistance in humans across all ages. We utilized a controlled benzene exposure system, continuous glucose monitoring (CGM) approach and indirect calorimetry in mice, to investigate the underlying mechanisms. Following exposure, disruptions in energy homeostasis, accompanied by modifications in the hypothalamic transcriptome and alterations in insulin and immune signaling, were observed exclusively in males, leading to a surge in blood glucose levels. In agreement, RNA-sequencing of microglia reveals increased expression of genes associated with immune response and NF-κB signaling. Selective ablation of IKKβ in immune cells (Cx3cr1GFP∆IKK) or exclusively in microglia (Tmem119ER∆IKK) in adult mice alleviated benzene-induced gliosis, restored energy homeostasis, hypothalamic gene expression, and protected against hyperglycemia. We conclude that the microglial NF-κB pathway plays a critical role in chemical-induced metabolic disturbances, revealing a vital pathophysiological mechanism linking exposure to airborne toxicants and the onset of metabolic diseases.

Article Highlights

· The first meta-analysis, establishing a robust association between exposure to benzene, a prevalent airborne VOC, and insulin resistance in humans across all ages.

· Short-term benzene exposure in male mice results in hyperglycemia and disruptions in energy balance.

· Acute benzene exposure triggers hypothalamic insulin resistance and provokes an inflammatory shift in the microglial transcriptome.

· The microglial NF-κB pathway is critical in mediating hyperglycemia and metabolic dysregulation induced by benzene exposure.
Optimised proteomic analysis of insulin granules from MIN6 cells identifies Scamp3, a novel regulator of insulin secretion and content.
Authors: Norris Nicholas , Yau Belinda , Famularo Carlo , Webster Hayley , Loudovaris Thomas , E. Thomas Helen , Larance Mark , M. Senior Alistair , A. Kebede Melkam
Published: September 2024

Abstract

Pancreatic b-cells in the Islets of Langerhans are key to maintaining glucose homeostasis, by secreting the peptide hormone insulin. Insulin is packaged within vesicles named insulin secretory granules (ISGs), that have recently been considered to have intrinsic structures and proteins that regulate insulin granule maturation, trafficking, and secretion. Previously, studies have identified a handful of novel ISG-associated proteins using different separation techniques. Here, this study combines an optimized ISG isolation technique and mass spectrometry-based proteomics, with an unbiased protein correlation profiling and targeted machine learning approach to uncover 211 ISG-associated proteins with confidence. Four of these proteins: Syntaxin-7, Synaptophysin, Synaptotagmin-13 and Scamp3 have not been previously ISG-associated. Through colocalization analysis of confocal imaging we validate the association of these proteins to the ISG in MIN6 and human b-cells. We further validate the role for one (Scamp3) in regulating insulin content and secretion from b-cells for the first time. Scamp3 knock-down INS-1 cells show a reduction in insulin content and dysfunctional insulin secretion. These data provide the basis for future investigation of Scamp3 in b-cell biology and the regulation of insulin secretion.

Keywords: insulin secretory granule, beta-cell, pancreas, proteomics, syntaxin-7, synaptophysin, synaptotagmin-13, scamp3

Article Highlights

· This study optimizes insulin granule isolation techniques alongside enhanced proteomics analyses to establish the first murine insulin secretory granule proteome.

· We investigated what proteins are present on insulin granules from MIN6 cells to further our understanding of insulin granule biogenesis, trafficking, and secretion.

· We found 211 insulin granule-associated proteins and validated 4 novel proteins.

· Through further functional studies, we implicated Scamp3 as a novel protein that regulates insulin content and secretion in b-cells.
Prevalence, prognosis, and health care resource utilization in carriers of pathogenic germline variants in BRCA1/2 with incident early-stage breast cancer: a Finnish population-based study
Authors: Karihtala Peeter , Laatikainen Outi , Tuominen Samuli , Ågesen Trude , Eliasen Rasmus
Published: September 2024

Background and purpose: Data on real-world prevalence and outcomes in patients diagnosed with pathogenic germline variants in BRCA1 or BRCA2 (gBRCAm) breast cancer is sparse.
Material and methods: An observational cohort study including all patients diagnosed with incident early-stage breast cancer and recorded in Helsinki University Hospital data lake 2012–2022, accounting for one-third of the Finnish breast cancer patient population.
Results: Among 14,696 incident early-stage breast cancer patients, 11.2% (n = 1,644) were tested for gBRCAm. Of the tested population, 7.4% (n = 122) carried gBRCAm. Of the 122 gBRCAm patients, 95.1% (n = 116) were women, with a median age at diagnosis of 46.4 years. Among the same patient group, HER2 status was available for 87.7% (n = 107) of the patients. Among these, 49.5% (n = 53) had hormone receptor-positive (HR+), HER2-negative breast cancer, 13.1% were (n = 14) HER2-positive, and 37.3% (n = 40) of patients had triple-negative breast cancer. The tested patients were significantly younger compared with non-tested patients. No significant differences in overall survival or healthcare resource utilization between the tested patients with gBRCAm and gBRCA wild-type (gBRCAwt) were observed.
Interpretation: This comprehensive observational study supports previous findings of gBRCAm prevalence in the Western early-stage breast cancer population. While no differences in survival were observed between patients with gBRCAm and gBRCAwt, it is important to consider the potential influence of selection bias, particularly due to the younger gBRCAm testing target population and the overall low frequency of testing. Therefore, a substantial proportion of the patients carrying gBRCAm likely remained undiagnosed, and wider screening criteria are warranted.
Bladder cancer incidence and mortality among men with and without castration therapy for prostate cancer – a nation-wide cohort study
Authors: Hyldgaard Josephine M. , Nørgaard Mette , Hjort Peter E. , Jensen Jørgen B.
Published: September 2024

Background and purpose: Bladder cancer (BC) is a common malignancy in the Western World with men being diagnosed almost four times as often as women. The etiology of bladder cancer may involve sex hormones. Prostate cancer (PCa) patients treated with chemical castration, such as androgen deprivation therapy, or surgical castration, may therefore have a lower risk of developing bladder cancer.
Patients/material and methods: In a nation-wide population-based cohort study using national Danish registry data, we included a cohort of men with a first-time PCa diagnosis between 2002 and 2018 divided according to antihormonal treatment in the first year after PCa diagnosis and a comparison cohort consisting of 10 age-matched persons for each PCa patient. Each individual was followed from 1 year after PCa diagnosis until death or end of follow-up. We computed cumulative incidences (risk) and hazard ratios (HRs) for BC. In a second cohort analysis, we determined overall survival and BC-specific mortality, determined from date of BC diagnosis until death.
Results and interpretation: We included 48,776 PCa patients of whom 13,592 were treated with chemical castration, 2,261 with surgical castration, and 32,923 received no antihormonal treatment. The 5-year risk of BC for each PCa group was 1.1%, 0.7%, and 1.3%, respectively, corresponding to an adjusted HR of 1.13 (95% CI 0.98; 1.31), 0.95 (95% CI 0.62; 1.47), and 1.18 (95% CI 1.09; 1.28) compared to individuals without PCa. Patients receiving antihormonal treatment had a slightly lower incidence of BC compared to individuals without PCa, however, this was not supported by the HRs. The treatment, however, was not associated with overall survival.
Bioecology of blackflies (Diptera: Simuliidae) of the water basin of the Huebra River (Western Spain)
Authors: López-Peña David , Portillo-Rubio Manuel Salvador , García-Roger Eduardo Moisés , Lis-Cantín Álvaro , Falcó-Garí José Vicente
Published: September 2024

The objectives of this study were to analyse the diversity and geographical distribution of the blackfly species from the Huebra River basin located in Salamanca province, Western Spain. This research significantly contributes to expanding our knowledge of the Simuliidae family. The study not only increases and ameliorates faunal and bioecological data, but also enhances the understanding of blackfly species across the Spanish national territory. The identification of 23 species has led to the addition of six new records to the simuliid fauna of the region: Simulium (Nevermannia) armoricanum Doby & David, 1961; Simulium (Nevermannia) carthusiense Grenier & Dorier, 1959; Simulium (Nevermannia) naturale Davies, 1966; Simulium (Nevermannia) vernum Macquart, 1826; Simulium (Simulium) bezzii (Corti, 1914) and Urosimulium faurei (Bernard, Grenier & Bailly-Choumara, 1972), expanding the previously recorded 19 species to 25. This study also provides valuable insights into the biology and geographical distribution of these species. It sheds light on the ranges of altitude, water velocity, temperature and the depth of watercourses conducive to preimaginal development. Additionally, it offers new information on the abundance of larvae and pupae, revealing the diverse ecological gradients that influence their occurrence and distribution patterns. The results indicate that the diversity of blackfly species varies according to factors such as altitude, water velocity, turbidity, and water temperature.
Environmental factors affecting the distribution of Spongillidae (Porifera) in an artificial channel (in north-western Italy)
Authors: Gruppuso Laura , Fenoglio Stefano , Bo Tiziano , Moriondo Marta
Published: September 2024

The hydrographic network of the upper Po Valley (NW Italy) is characterized by the presence of numerous hydroelectric plants, often powered by artificial channels. These man-made water courses, which range from a few hundred meters to several kilometers in length, are used to convey water from the rivers to the electricity production plant. Power canals are usually characterized by concrete banks and bottoms, a geometric profile, and the absence of riparian vegetation so that they host peculiar invertebrate communities, often extremely well adapted to life in a completely artificial habitat. Sponges are an often little considered component of the freshwater macroinvertebrate fauna, whose functions and role within communities can be of considerable interest. These sessile, filter-feeding organisms can colonize artificial channels, but little is known about the local environmental characteristics that influence their distribution. In this study, we investigated the distribution of a freshwater sponge family Spongillidae, in a 4.5 km long artificial channel in Rocca Grimalda (Alessandria, NW Italy). A total of 863 specimens were localized and measured, and selected environmental characteristics were recorded. Results suggested that the distribution of sponges depends mainly on the lighting rather than the type of substrate or other local factors, so that this taxon is well-suited to colonizing artificial environments with good water quality conditions.
Methodology for managing personnel risks in enterprises
Authors:   Lviv Polytechnic National University, Bortnikova Mariana , Stasyuk Nazar ,   Lviv Polytechnic National University, Malynovska Yuliia ,   Lviv Polytechnic National University
Published: September 2024

This article analyzes the essence of personnel risks of enterprises and develops a methodology for managing them. The methodology for managing personnel risks of an enterprise primarily involves identifying the risk and identifying its components. It also includes various aspects of the process of managing personnel and the enterprise as a whole, the key elements of which are: personnel risk factors; indicators of personnel risks; probable losses or gains; methods of personnel risk management; budgeting; Implementation deadlines. It is noted that the development of methods for managing personnel risks begins only when the critical point of the onset of negative consequences of the implementation of personnel risks in the functioning of the enterprise is reached, which entail serious problems. The main methods of managing personnel risks of an enterprise have been identified, which include preventive and reactive methods. The preventative method is to eliminate personnel risks before they reach the crisis stage. The reactive method is aimed at eliminating the negative consequences of personnel risks. Both methods should be used in the process of managing personnel risks of an enterprise. The proposed system of methods for managing personnel risks of an enterprise, built on the main stages of the personnel management process, allows us to formulate a number of recommendations in order to neutralize the impact of personnel risks, namely: recruitment, selection and selection of personnel, adaptation of personnel to working conditions at the enterprise; employee assessment and certification; personnel training and development; dismissal of workers. It has been proven that managing personnel risks requires the use of a set of measures to eliminate them. For this purpose, it is advisable to use risk transfer methods through outstaffing, outsourcing or personnel leasing. It is indicated that the management of personnel risks of an enterprise is closely related to the goals and objectives of the strategic development of the enterprise; personnel management system; personal assessment of employees and continuous identification and monitoring of the performance of enterprise personnel. Based on the results of the study, the main directions for minimizing the impact of personnel risks of the enterprise were identified, and the main methods for avoiding them were proposed.
Modern approaches to the strategic management of human resources at the enterprise
Authors:   Lviv Polytechnic National University, Podra Olha , Petryshyn Nataliia ,   Lviv Polytechnic National University, Kyrychuk Ihor ,   Lviv Polytechnic National University
Published: September 2024

The article examines the essence of strategic management of human resources at the enterprise, carries out a theoretical generalization of key concepts and provisions, analyzes the key tasks, methods and functions of strategic management of human resources. Human resources are an important strategic asset of the enterprise, for which new management methods must be found in order to ensure the effectiveness of work in the long term. Under such conditions, the study of the possibilities of strategic management of the company’s human resources, which will ensure the competitiveness and viability of a specific organization, becomes relevant. The modern concept of human resources management of the enterprise should be strategic, that is, its main goal should be the effective use of the labor potential of the enterprise, adequate to the conditions of the external and internal environments, in order to achieve success in the long term. It has been established that in the process of human resources management it is customary to distinguish three approaches: economic, organizational and humanistic. The main tasks of strategic management of human resources are studied, including the improvement of personnel policy, the use and development of human resources, the selection and implementation of the style of management of labor resources, the organization of horizontal coordination and cooperation, the improvement of the organization of workplaces and working conditions, recognition of personal achievements at work, and stimulation. The effectiveness of the strategic management of the company’s human resources lies in the ability of managers of all levels to interact for the effective functioning of the organization. The technology of human resource management based on high involvement (HIHRM – high involvement approach to HRM or HIHRM) is researched – it is a policy and procedures aimed at involving employees in making management decisions, as well as providing employees with skills and independence. The recommended process of implementing the technology of human resources management based on the high involvement of HIHRM at the enterprise is proposed.
Fighting smuggling in Ukraine: measures and challenges
Authors:   Lviv Polytechnic National University, Hryhoriev Oleksandr , Svyryda  ,   Lviv Polytechnic National University
Published: September 2024

Ukraine, as a modern state, faces the challenge of effectively combating smuggling, which not only leads to significant budget losses but also poses a threat to national security and economic development. This article discusses the key aspects of this problem, from the causes of smuggling of equipment to the low level of incentives for customs officers and the threats they face. The reasons for smuggling are discussed, such as corruption, excessive customs duties and taxes, and imperfect legislation. The article also considers the need for parliamentary and public control over the actions of customs and border authorities, as well as optimization of taxation to ensure effective protection of the domestic market. Particular emphasis is placed on the importance of international cooperation, technical support, dog training and public education for the successful fight against smuggling. The article also discusses the problem of low salaries and poor incentives for customs officers, which can jeopardize the effectiveness of the fight against smuggling. The article concludes with a section on possible threats to customs officials and ways to address them, including the possibility of threats, bribery and other negative influences that complicate their work. This article also discusses comprehensive measures such as technical support for customs, the development of a dog service, and the importance of public education for the successful fight against smuggling. The low level of salaries among customs officers and their weak incentives to disclose smuggling schemes are seen as a systemic problem that requires a comprehensive approach and solution. The author analyzes the threats that may be directed at customs officials by smugglers and criminal elements. Scenarios of influence, possible bribery, threats and other negative interactions are discussed in order to ensure effective measures to protect customs and border services. All these aspects interact and influence the success of the fight against smuggling in Ukraine. The article highlights the need for a systematic approach and cooperation of all stakeholders – government agencies, the public and international partners – to create an effective system that minimizes the risks and losses from smuggling.
Higher economic education and the needs of the modern labor market
Authors:   Lviv Polytechnic National University, Kozyk Vasyl , Seliuchenko Nadiia ,   Lviv Polytechnic National University
Published: September 2024

The issue of the quality of higher economic education, and its compliance with the requirements of applicants was and is relevant for all educational systems, regardless of the level of economic development of the country. In the conditions of a full-scale war in Ukraine, institutions of higher education should be oriented as much as possible to the formation of competitive educational programs that would take into account the needs of the modern labor market and the post-war recovery of Ukraine. The purpose of the article is to study the needs of the modern labor market for economic specialists and their consideration in the educational programs of higher education institutions in Ukraine. Small and medium-sized businesses are the drivers of economic development and the formation of its innovative potential at the current stage. The dynamic development of the digital economy causes changes in the labor market and, in particular, the gradual demise of certain professions, which requires the development of entrepreneurial abilities in young people, regardless of their education. In addition, the experience of recent years shows that in unstable economic and socio-political conditions (the COVID-19 pandemic, full-scale war in Ukraine), it is small and medium-sized businesses that provide the opportunity to save jobs, provide for consumer needs, and support the socio-economic well- being of local communities and the economy of the state in general, filling its budget. Therefore, the modern labor market is most in need of specialists who would be competent in matters of the economics of small and medium-sized business entities, possess economic methods, and tools, and levers for justifying business decisions, have practical skills in using modern information and communication technologies in business, and were also socially responsible. Taking into account the above, educational programs in economics should be aimed at training specialists who will possess modern economic thinking, theoretical knowledge and practical skills necessary for making informed decisions regarding the functioning of socio-economic systems of various levels, but the emphasis should be placed on business and the conditions of its functioning.
Analyze Consumer Purchase Decisions Purebred Chicken Meat in Banjarbaru City: Factor Analysis Approach
Authors: Pramesty Rahmayanti Annisa , Yanti Nuri Devi , Ferrianta Yudi
Published: September 2024

Purebred chicken meat is the most consumed meat by the public among other types of protein. Purebred chicken meat is very easy to find on the market. In addition to the affordable price, purebred chicken meat is easy to process for various dishes used at home. This study aims to analyze the characteristics of purebred chicken meat consumers in Banjarbaru City and analyze the factors that affect the decision to purchase purebred chicken meat in Banjarbaru City. The research uses primary and secondary data. Primary data is taken from consumers who buy purebred chicken meat in the market. Secondary data was taken from the Central Statistics Agency of South Kalimantan Province and the South Kalimantan Plantation and Livestock Office. Factor analysis was used to see the correlation between variables; namely, as many as 28 variables were used to see the correlation. The results of the study show that most consumers are women (85.93%), with housewives as the most buyers (30%) in the age range of 21–30 years, the last education is high school/equivalent (50%), with the highest expenditure of <Rp 2,000,000 (50%). The frequency of chicken meat purchases on weekdays and holidays occurred 2–4 times (68.33%) and (50.83%). The decision to buy purebred chicken meat in the city of Banjarbaru is influenced by four factors, namely quality of service with an eigenvalue of 10.190 (36.39%), location factors with eigenvalues of 4.872 (17.40%), meat quality factors of 2.627 (9.38%) and price factors with eigenvalues of 1.854 (6.62%), which are combined (cumulative eigenvalues) to 69.79% explained about these four factors while 30.21% explained by factors outside the service (quality of service), location, meat quality and price.
Prevalence of SARS-CoV-2 and Associated Factors Among Individuals During the Second Wave of Infection in Yaounde, Cameroon
Authors: Nguwoh Philippe Salomon , Ngounouh Christian Taheu , Essomba René Ghislain , Ngo Likeng Julienne Louise , Akenji Mboringong Blaise , Halilou Ibrahima , Moussa Nafissatou Ibnou , Bit Younouss Amina Al-Mayé , Olinga Patrice Zanga , Nguepidjo Gilbert , Tonmeu Douyong Sandrine Chimène , Tchoffo Désiré , Kamga Henri Lucien , Assoumou Okomo Marie Claire , Fokam Joseph
Published: September 2024

Background: The first case of new severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was reported in Cameroon on March 5, 2020, in Yaounde. Since then, viral propagation occurred nationwide with a higher burden in urban settings and limited evidence on transmission patterns. Our objective was to determine the prevalence of SARS-CoV-2 and associated factors among individuals in urban settings of Cameroon during the second wave of the pandemic.
Methods: a population-based cross-sectional survey was conducted from January 18 to April 26, 2021, among 807 consenting individuals living in four major districts of the city of Yaoundé. Out of 711 nasopharyngeal swabs collected, 671 tests were performed by SARS-CoV-2 ribonucleic acid (RNA) extraction and real time-polymerase chain reaction (RT-PCR) at the National Public Health Laboratory (NPHL). Data were analysed using SPSS v21.0, with p < 0.05 considered statistically significant.
Results: overall SARS-CoV-2 RNA positivity rate was 11.62% (78/671), without any significant difference between males and females with 10.9% versus 12.20% respectively (OR = 0.87, p = 0.5). However, clinical status was associated with SARS-CoV-2 RNA positivity rate in symptomatic (26.3%) vs. asymptomatic (9.7%) individuals (Odds Ratio [OR] = 3.30, p = 0.0001). Other factors associated with SARS-CoV-2 RNA positivity include exposure to more than 15min with confirmed cases, wearing a non-conventional facemask (p ˂ 0.05), the practice of occasional hand hygiene before and after contact with patients (OR = 3.60, p < 0.0001) or always as recommended (OR = 0.28, p = 0.0001), hand hygiene before and after occasional contact with objects (OR = 2.05, p = 0.0043) or always as recommended (OR = 0.48, p = 0.0027), surgical mask (OR = 0.17, p = 0.013) and standard mask (p = 0.026).
Conclusion: From this urban setting of Cameroon, coronavirus disease 2019 (COVID-19) reached an alert burden (10-20%) during the second wave of the pandemic at the district level. Interestingly, SARS-CoV-2 infection was driven by the presence of symptoms, close contact with confirmed cases, limited adherence to recommended barrier measures, and the use of non-conventional facemasks.
Statistical Study on Maternal Immunological Adaptation During Normal Pregnancy
Authors: Yousif Samar Kadhim
Published: September 2024

Background: The immune system of the mother’s body undergoes several modifications throughout pregnancy to protect the baby from harm and prevent the mother’s immune system from attacking it. In addition, physiological and immunological changes that occur during pregnancy increase the risk and severity of some infections. Aim of the study: Provide comprehensive documentation of immune system adaptation in pregnant mothers and variables associated with the immune system. Methods: In this study, 40 pregnant women between the ages of 15 and 43 participated. The Abu Alkhaseeb General Hospital in Basra City filed data from March 2023 to August 2023. The data gathered included age, the number of abortions, the impact of WBC levels during pregnancy, and frequent diseases during pregnancy. Results and Discussion: Urinary tract infection was found to be the most frequent referral among pregnant women, constituting about 62% of the data, and comparisons of proportions were performed. A p-value below 0.05 was considered statistically significant. The results indicated that the number of white blood cells in the first, second, and third trimesters does not differ significantly. The highest white blood cell count was recorded in the third trimester (10.34), while the percentages for the first and second trimesters were close at 9.935 and 9.510, respectively. Conclusion: There are no significant associations with maternal white blood cell count during the first, second, and third trimester. Urinary tract infection was indicated to be the most frequent among pregnant women. 86% of pregnant women did not miscarry.
De la co-labor a la conformación de una comunidad epistémico-afectiva
Authors: Álvarez Ávila Carolina , Palladino Lucas
Published: September 2024

Se aborda en este trabajo una experiencia extensionista cuyo objetivo fue construir una cartografía social a partir del mapeo participativo con comunidades indígenas en Córdoba, Argentina. Desde las nociones de co-labor, horizontalidad y reflexividad, se identifican demandas de corto alcance e interpelaciones mayores y se analizan las implicancias tanto para el grupo universitario como para las comunidades indígenas. Finalmente, se reflexiona sobre el trabajo horizontal y colaborativo, sus limitaciones y afectaciones vividas, y su capacidad de configurar lo que denominamos una «comunidad epistémico-afectiva».
Analisis Faktor Risiko Asfiksia Neonatorum di RSUD Labuang Baji Makassar Tahun 2021
Authors: Shanun Shari Sakunti  , Rini Fitriani  , Syatirah Jalaluddin  , Andi Tihardimanto
Published: September 2024

Asfiksia merupakan penyebab kedua terbanyak kematian neonatal di Indonesia pada tahun 2019 dengan kasus sebanyak 5.464 kasus. Asfiksia terjadi karena kurangnya aliran darah ataupun pertukaran gas dari atau ke janin pada bayi baru lahir. Jika keadaan ini tidak ditangani secara cepat dan tepat maka dapat menyebakan kerusakan organ vital. Tujuan penelitian ini untuk mengetahui faktor risiko yang mempengaruhi kejadian asfiksia neonatorum di RSUD Labuang Baji Makassar. Desain penelitian yang digunakan yaitu analitik observasional dengan pendekatan case control. Pengambilan sampel dilakukan dengan teknik purposive sampling dengan menggunakan data sekunder berupa rekam medik pasien. Dari sampel 47 kasus dan 47 kontrol dengan uji chi square odd rasio didapatkan ibu dengan anemia, Ibu dengan Ketuban Pecah Dini (KPD), Berat Badan Lahir Rendah (BBLR) dan usia gestasi merupakan faktor resiko terjadinya kejadian asfiksia neonatorum  di RSUD Labuang Baji Makassar Tahun 2021 dengan hasil yang signifikan P-Value ≤ 0,05 dan masing-masing nilai OR 3,410; 3,872; 7,451; 7,765.
Diaphyseal Tibia and Fibula Malunion Treated with Open Osteotomy and Internal Fixation: A Case Report
Authors: Fauzie Rivaldy Prayudha Adirachman , Kuswardhana Helmiyadi
Published: September 2024

Diaphyseal fractures of the tibia and fibula often occur due to traffic accidents. Bone fractures can heal well with proper treatment. However, many cases that are neglected lead to complications such as malunion, particularly in developing countries. Malunion occurs when a fractured bone heals with the fragments in improper positions. Malunion in bone fractures can lead to complications such as decreased bone or limb function, deformities, pain, non-union, avascular necrosis, and limb shortening. This case study reports on a 29-year-old woman with malunion in the tibia and fibula due to a neglected bone fracture for eight months. Symptoms include pain, deformities, and limb shortening. The management involved open osteotomy and ORIF (open reduction with internal fixation), demonstrating that ORIF and osteotomy are successful surgical techniques for correcting malunion in this case. The goals of surgical treatment for malunion are to restore function, reduce discomfort, and correct visually apparent abnormalities.
Analisis Kadar Rasio Neutrofil Limfosit (RNL) pada Balita dengan Pneumonia di Rsia Ananda Kota Makassar
Authors: Nur Azizah  , Henny Fauziah  , Saharuddin  , Saraswati W. Hartono  , Ambo Asse
Published: September 2024

Kadar Rasio Neutrofil Limfosit (RNL), sebagai prediktor inflamasi yang diperoleh dari hasil bagi antara neutrofil absolut dengan limfosit absolut, menunjukkan adanya peningkatan pada berbagai penyakit yang memicu inflamasi terutama pada pneumonia dengan komplikasi dan tingkat mortalitas yang lebih tinggi. Tujuan dari penelitian ini adalah untuk menganalisis perbedaan kadar RNL pada balita dengan pneumonia dan balita dengan Infeksi Saluran Pernapasan Akut Atas/ISPA Atas yang bukan pneumonia di RSIA Ananda Kota Makassar. Penelitian ini menggunakan desain analitik observasional dengan pendekatan cross sectional. Sampel penelitian berjumlah 139 sampel dan berasal dari populasi balita (usia 12-59 bulan) yang dibagi menjadi sampel pneumonia dan bukan pneumonia (ISPA Atas) yang memiliki hasil pemeriksaan darah rutin dan data rekam medis yang lengkap. Analisis data menggunakan uji univariat dan bivariat (Independent T Test). Dalam penelitian ini, rerata RNL pada sampel pneumonia lebih rendah jika dibandingkan dengan bukan pneumonia (ISPA Atas) dan juga ditemukan tidak adanya perbedaan yang signifikan antara kadar RNL pada sampel pneumonia dan bukan pneumonia (ISPA Atas). Oleh karena itu, kesimpulan penelitian ini menunjukkan tidak adanya peningkatan yang bermakna pada RNL balita dengan pneumonia.
Hubungan Screen Time dan Kualitas Tidur dengan Kebugaran Kardiorespirasi pada Mahasiswa Pendidikan Dokter UIN Alauddin Makassar
Authors: Putri Auliah Zahrani  , Trisnawaty  , Miswani Mukani Syuaib  , Halimah Sa’diyah  , Takdir
Published: September 2024

Gaya hidup modern yang cenderung pada kesenangan yang serba instan telah mempengaruhi masyarakat secara signifikan, menyebabkan kecenderungan akan gaya hidup tidak sehat semakin meningkat. Penelitian ini dilakukan dengan tujuan untuk mengetahui hubungan screen time dan kualitas tidur dengan kebugaran kardiorespirasi pada mahasiswa pendidikan dokter UIN Alauddin Makassar. Desain penelitian pada penelitian ini yaitu kuantitatif dengan pendekatan cross sectional. Populasi pada penelitian ini adalah mahasiswa pendidikan dokter UIN Alauddin Makassar. Teknik pengambilan sampel yang digunakan adalah purposive sampling dengan jumlah sampel sebanyak 140 sampel. Data diperoleh dengan pengisian Questionnaire for Screen Time of adolescent (QueST) untuk screen time, kuesioner Pittsburgh Sleep Quality Index (PSQI) untuk kualitas tidur serta kebugaran kardiorespirasi diukur dengan melakukan harvard step test. Data dianalisis menggunakan uji univariat dan bivariat menggunakan aplikasi SPSS dengan uji statistik spearmen rho. Hasil analisis bivariat antara variabel screen time dan kualitas tidur menunjukkan screen time dengan p-value sebesar 0,000 (p < 0,05), kualitas tidur dengan p-value sebesar 0,000 (p < 0,05) yang bermakna bahwa terdapat hubungan yang signifikan antara screen time dan kualitas tidur dengan kebugaran kardiorespirasi. Penelitian ini dapat disimpulkan terdapat hubungan yang signifikan antara screen time dan kualitas tidur dengan kebugaran kardiorespirasi pada mahasiswa pendidikan dokter UIN Alauddin Makassar.
Analysis the Healthy School Campaign in Indonesia: A Health Policy Triangle Approach
Authors: Dewi Ni Made Umi Kartika , Januraga Pande Putu , Anton Sri Sulistyawati
Published: September 2024

The School Health Program policy was initiated by the Indonesian government in 2014. However, by 2021, student health service coverage was still suboptimal. The Healthy Schools Campaign Program was introduced in 2022 as an alternative policy to revitalize the School Health Programme. The study aimed to analyze the Healthy School Campaign Program using the health policy triangle framework, which includes actors, content, process, and context. This research uses qualitative methods with secondary data sourced from electronic document searches. The main actors in this policy involve official government institutions, supported by collaboration with non-government partners. Policy selection is based on situational, structural, cultural and international contextual factors. The program content focuses on physical health, healthy nutrition, and student immunization. The conclusion is that the selection of content is influenced by how actors identify health problems in the early stages of policy preparation. Implementation of this program requires a clear collaboration system as a reference for its implementation in educational units. Teacher and parent involvement is also very important to increase the effectiveness and sustainability of the program.
Detection of trichothecene producing Fusarium spp. by PCR: adaptation, validation and application to fast food
Authors: Agodi Antonella , Barchitta Martina , Ferrante Margherita , Sciacca Salvatore , Niessen Ludwig
Published: September 2024

Background. Food contamination by trichothecene mycotoxins is considered to be an emerging publichealth problem. The aim of this study was to validate a rapid sonification protocol, previously set up forcereal Fusarium DNA extraction from fast food samples, produced by a centre for research and developmentin the food industry in Catania, Sicily, and to validate it for a diagnostic PCR assay targeted at tri5, the keygene of trichothecene biosynthesis.Methods. DNA from reference Fusarium spp. strains and from fast food samples was prepared, setting up anextraction protocol adapted using some modifications based on a method recently described. Validationexperiments were performed: serial dilution of DNA extracted from fungal cultures were added to foodsamples and then DNA was extracted. Specific primer pairs were used to detect F. graminearum and F.culmorum DNA in species-specific assays as well as trichothecene-producing Fusarium spp. in a group-specific system.Results. All genomic DNA extracted from trichothecene-producing Fusarium spp. as well as from DNA-spikedfast food samples and from food still in it’s original condition resulted in the correct amplification. Thedetection limit was 1 x 10-4μg of DNA. All fungal and food samples tested gave highly consistent results inrepeatability assays, thus demonstrating the within-lab and within/between-day precision of the method.Conclusions. Information on the epidemiology of trichothecene producing Fusarium through the food chainand the identification of the most frequently contaminated components of fast food are essential in order todevelop effective public health strategies for minimising consumer exposure to trichothecenes.