bluuebunny/crossref_metadata_2025 huggingface dataset:
Inhibitory action of methylene bisphosphonic acid on metabolic activity and viability of J774A.1 cells
Authors:   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv, Labudzynskyi D. O. , Pasichna E. P. ,   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;, Krynina O. I. ,   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;, Veliky М. M. ,   Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, Kyiv;
Published: April 2024

Bisphosphonates (BPs) are primary agents in the current pharmacological arsenal against osteoclast-related bone loss due to osteoporosis, Paget’s disease and bone tumors. Due to the lack of complete understanding of the molecular mechanism of their action in bone tissue and the overlap of key properties between BPs of different generations, integral studies of BPs inhibitory and antiresorptive properties are relevant today. The present work was carried out to establish a comprehensive study of the inhibitory effects of methylene bisphosphonic acid (MBPA) on the mevalonate pathway, metabolic activity and cell death in vitro compared to zoledronic acid (Zol). Farnesyl pyrophosphate synthase activity of MBPA-treated J774A.1 cells was inhibited by 80%, compared with a 79% reduction in Zol-treated samples. The ability of MBPA to decrease the percentage of viable cells in culture is slightly lower compared with Zol. After 24 h of incubation with lowest concentration, the percentage of inhibition of metabolic activity was 10.6 and 25%, respectively. After 48 h, these values were 34.8 and 55.6%, respectively. The inhibitory effects of MBPA and Zol on the intensity of incorporation of radioactively labeled precursor [14C]-acetate to the cholesterol fraction were 76.2 and 59.1%, respectively. In the case of isoprenoid fraction, the inhibitory effects were 40.9% and 51.2%, respectively. MBPA and Zol differently induced apoptosis in the J774A.1 cells culture, increased count of apoptotic cells in 2.4 and 6.3 times, and also increased the number of propidium iodide-positive cells in 7.4 and 19 times, respectively. MBPA and Zol also increased the number of TUNEL-positive cells in macrophage culture in 2.6 and 5 times, respectively. Zoledronate significantly reduced carbonic anhydrase 2 and nuclear factor of activated T-cells 1 gene expression levels compared to the MBPA action. Thus, the use of MBPA in future research and therapy of both cancer and osteoporosis looks promising due to lower cytotoxicity, high efficiency of mevalonate pathway inhibition and the possibility of dosage variation. Keywords: cell death, cell viability, FPPS enzymatic activity, gene expression, J774A.1 macrophages, methylene bisphosphonic acid, radioisotopes., zoledronic acid
Obtención y caracterización parcial de la proteína humana mutante α-sinucleína G51D y la producción de su anticuerpo policlonal
Authors: Rey Buitrago Mauricio , Gantiva Gantiva Mauricio
Published: April 2024

La α-sinucleína (SNCA) es una proteína que participa en la formación de agregados, cuya presencia es distintiva para todas las α-sinucleinopatías y algunas adicciones. Las alteraciones en el gen que codifica la SNCA y en la síntesis de esta proteína han sido relacionadas con procesos de agregación que alteran su conformación y adquieren capacidad autoagregante, lo cual está relacionado con su presencia en las neuronas dopaminérgicas y podría ser un factor fisiopatológico significativo en la progresión de enfermedades. Una de las variantes génicas más comunes de la SNCA es la G51D, la cual podría ser un indicador anatomopatológico para enfermedades neuronales y adicciones de larga duración. En el presente estudio se exponen las técnicas de expresión, purificación y caracterización de la proteína recombinante SNCA G51D, además de ensayos de agregación. Así mismo, se detallan las circunstancias para la obtención del anticuerpo de tipo policlonal dirigido hacia la SNCA G51D. También se realizó la optimización para la clonación de esta variante, utilizando el vector pET30a, el cual nos brindó la mayor solubilidad in silico. La proteína recombinante permitió la obtención de un anticuerpo policlonal anti SNCA G51D, que se caracterizó parcialmente y podría ser una herramienta inmunológica significativa en la confirmación de la existencia de proteínas mutantes en muestras de interés.
Conocimiento de enfermedades virales terapéuticas: aplicación de SWCNT en la administración de fármacos
Authors: Mollaamin Fatemeh
Published: April 2024

En este trabajo se ha evaluado el fármaco Nirmatrelvir para tratar el coronavirus utilizando como método de administración de fármacos la adsorción en la superficie de nanotubos de carbono de pared simple (SWCNT), debido al principio de transferencia directa de electrones, la cual ha sido estudiada mediante el método de la teoría funcional de la densidad (DFT). Por lo tanto, se ha implementado el método CAM–B3LYP/6–311+G (d,p) para estimar la susceptibilidad de los SWCNT para adsorber Nirmatrelvir mediante resonancia magnética nuclear y parámetros termodinámicos. Además, el modelo de Onsager ha influido en los datos de resonancia magnética nuclear y en el blindaje químico de los átomos de carbono (C), nitrógeno (N), oxígeno (O) y flúor (F) en el complejo Nirmatrelvir–(5,5) sillón SWCNT. También se ha delineado el potencial eléctrico de resonancia cuadripolar nuclear para algunos átomos de C, N, O y F en el proceso de adsorción de Nirmatrelvir en el (5,5) sillón SWCNT que ha sido calculado por CAM–B3LYP/EPR–III, 6–311+G (d,p). Este estudio sugiere que la combinación de nanotubos de carbono (CNT) y Nirmatrelvir puede ofrecer una fórmula viable para la administración de fármacos, respaldada por cálculos de mecánica cuántica y propiedades fisicoquímicas de la resonancia cuadrupolar nuclear (RCN), la resonancia magnética nuclear (RMN), el infrarrojo (IR) y enfoques ultravioleta/visibles (UV–VIS). En este trabajo, se emplearon farmacología en red, análisis de metabolitos y simulación molecular para dilucidar la base bioquímica de los efectos promotores de la salud del Nirmatrelvir en la administración de fármacos con CNT. Los datos explican que la viabilidad de utilizar SWCNT y Nirmatrelvir se convierte en la norma en el sistema de administración de fármacos, lo que se ha logrado mediante cálculos cuánticos debido a las propiedades fisicoquímicas.
Materials of the XI Forum of Young Cardiologists of the Russian Society of Cardiology with international participation "Modern trends in the development of cardiology: new clinical solutions", May 31 — June 1, 2024, Krasnodar
Authors: Editorial Article
Published: April 2024

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IN MEMORIAM: MIKHAIL DIMITROV MIKHAILOV
Authors: Cotta Renato Machado , Orlande Helcio Rangel Barreto , Chiu Wilson K. S.
Published: April 2024

This is an eulogy to late Prof. Mikhail Dimitrov Mikhailov
EFFECTS OF ADDING PHTHALOCYANINE TO GASOLINE FUEL ON ENGINE PERFORMANCE AND EXHAUST EMISSIONS IN SPARK IGNITION ENGINE
Authors: Yakın Ahmet , Cabir Beyza
Published: April 2024

In this study, phthalocyanines as fuel additives were added to petrol fuel at different ratios by volume and tested in terms of engine performance and exhaust emissions. In the experimental study, the change in engine torque of PG5, PG15, and PG25 blended fuels compared to gasoline fuel was 3.5% decrease, 0.37% increase, and 3.59% increase, respectively. Specific fuel consumption decreased by 6.09% for PG5 fuel, 3.53% for PG15 fuel, and 5.08% for PG25 fuel compared to petrol fuel. The exhaust gas temperature increased by 7.18%, decreased by 0.39%, and decreased by 3.31% with the use of PG5, PG15, and PG25 blended fuels compared to petrol fuel, respectively. CO emissions of PG5, PG15, and PG25 blended fuels decreased by 58.88%, 46.99%, and 53.19%, respectively, compared to gasoline fuel. HC, CO2, and NOx emissions of blended fuels increased compared to petrol fuel. Phthalocyanines additives are a type of fuel additive that can help to reduce both fuel consumption and harmful emissions. This can lead to a decrease in vehicle-related environmental pollution.
Development and performance evaluation of a novel high-ductility fiber-reinforced lime-pozzolana matrix for textile reinforced mortar (TRM) masonry strengthening applications
Authors: Illampas Rogiros , Rigopoulos Ioannis , Ioannou Ioannis
Published: April 2024

This paper discusses the development of a high ductility fiber reinforced lime mortar with deflection hardening behavior. In this study, polypropylene fibers have been incorporated in a cementless reference matrix comprising of Natural Hydraulic Lime, silica fume, siliceous aggregates and workability aid admixtures. The properties of the reference and fiber reinforced mortar compositions were assessed by means of standardized laboratory tests and scanning electron microscopy. The reference composition gave an average compressive strength of 12 MPa, rendering it suitable for structural applications. Fiber addition at a dosage of 0.76% by wt. of solids led to a reduction of the compressive strength; however, sufficient load bearing capacity was still achieved (8 MPa). More importantly, the fibers enabled the mortar to sustain useful load after damage initiation, improving post-peak ductility under compression and allowing the material to reach bending stresses up to 20% higher than the first-crack strength. To evaluate the practical application of the proposed materials, their use as matrices in textile reinforced mortar (TRM) strengthening systems was investigated through pilot applications on stone masonry. Diagonal compression tests were performed on 9 ashlar masonry wallettes, including both un-retrofitted and TRM-retrofitted specimens. Single-sided TRMs consisting of alkali resistant glass textiles embedded in either the reference or the fiber reinforced mortar were considered. Specimens retrofitted with TRM constructed using the fiber reinforced mortar, exhibited a remarkable ~ 270% increase in shear strength and > 50% higher deformation capacity, compared to un-retrofitted ones. The strength increment achieved with the reference mortar as the TRM matrix was 80%, with minimal impact on ductility. The TRM comprising the fiber reinforced mortar also showed superior performance in terms of ability to retain integrity at high levels of shear deformation. Overall, the results indicate that the use of fiber reinforced lime matrices in TRM systems applied to masonry substrates has the potential to substantially enhance mechanical performance under in-plane loading, even in cases where only single-sided retrofitting can be realized.
Relationship between intraoperative requirement for anesthetics and postoperative analgesic consumption in laparoscopic colectomy: a randomized controlled double-blinded study
Authors: Lee Jun Ho , Doo A Ram , Oh Hyunji , Lee Hyungun , Ko Seonghoon
Published: April 2024

Background: This study investigated the relationship between intraoperative requirement for an inhalational anesthetic (sevoflurane) or an opioid (remifentanil) and postoperative analgesic consumption. Methods: The study included 200 adult patients undergoing elective laparoscopic colectomy. In the sevoflurane group, the effect-site concentration of remifentanil was fixed at 1.0 ng/ml, while the inspiratory sevoflurane concentration was adjusted to maintain an appropriate anesthetic depth. In the remifentanil group, the end-expiratory sevoflurane concentration was fixed at 1.0 volume%, and the remifentanil concentration was adjusted. Pain scores and cumulative postoperative analgesic consumptions were evaluated at 2, 6, 24, and 48 h after surgery. Results: Average end-tidal concentration of sevoflurane and effect-site concentration of remifentanil were 2.0 ± 0.4 volume% and 3.9 ± 1.4 ng/ml in the sevoflurane and remifentanil groups, respectively. Cumulative postoperative analgesic consumption at 48 h postoperatively was 55 ± 26 ml in the sevoflurane group and 57 ± 33 ml in the remifentanil group. In the remifentanil group, the postoperative cumulative analgesic consumptions at 2 and 6 h were positively correlated with intraoperative remifentanil requirements (2 h: r = 0.36, P < 0.01; 6 h: r = 0.38, P < 0.01). However, there was no significant correlation in the sevoflurane group (r = 0.04, P = 0.69). Conclusions: The amount of intraoperative requirement of short acting opioid, remifentanil, is correlated with postoperative analgesic consumption within postoperative 6 h. It may be contributed by the development of acute opioid tolerance. However, intraoperative sevoflurane requirement had no effect on postoperative analgesic consumption.
Reformer Pilates Egzersizleri Vücut Yağ Oranını Etkiler mi?
Authors: Akpınar Kocakulak Neşe , Özdemir Nurgül
Published: April 2024

Pilates güç esneklik, kas kontrolü, dikkat, duruş ve doğru nefes alma egzersizlerini içeren bir vücut ve zihin antrenman rejimidir. Bu çalışmada hem aerobik hem de anaerobik egzersiz özelliği göstermeyen, daha ziyade koordinasyon ve dengeyi geliştirmeye önem veren reformer pilatesin sedanter kadınlarda toplam vücut kütlesi ve çevre ölçümlerine etkisi araştırılmıştır. Çalışmaya 22-45 yaş aralığında 22 gönüllü kadın katılmıştır. Katılımcılar 4 hafta boyunca, haftada 2 gün 60 dakika (dk) reformer pilates egzersizleri yapmışlardır. Egzersizden önce 10 dk ısınma, egzersizden sonra 10 dk soğuma hareketleri yaptırılmıştır. Çalışma süresince katılımcılara herhangi bir diyet program uygulanmamıştır. Uygulanan egzersiz programından önce ve sonra vücut yağ yüzdesi (%) ve vücut ağırlıkları (kg) Segmental Vücut Analizi sistemi ile göğüs, bel, karın kalça, biceps, uyluk, baldır çevre ölçümleri Gulick mezura ile ölçülmüştür. Araştırmada normal dağılım gösteren veriler Paired Sample t-Test, normal dağılım göstermeyen veriler non-parametrik testlerden Wilcoxon test ile analiz edilmiştir. Çalışmamızın bulgularına göre çevre ölçümlerinde (göğüs, karın, kalça, baldır, uyluk, biceps) anlamlı (p
Development of an educational intelligent system for analysis of polymer materials in additive manufacturing
Authors:   Kazan (Volga region) Federal University, Russian Federation, Farahov Rustam R. , Burnashev Rustam A. ,   Kazan (Volga region) Federal University, Russian Federation, Nasibullin Ilnur A. ,   Kazan (Volga region) Federal University, Russian Federation, Enikeev Arslan I. ,   Kazan (Volga region) Federal University, Russian Federation, Bolsunovskaya Marina V. ,   Peter the Great St. Petersburg Polytechnic University, Russian Federation
Published: April 2024

The work presents the “Expert Polymer” educational intelligent system for identifying particles suitable for 3D printing. The software package is designed to analyze images of polymer materials on a production site using optics. It is planned that this intelligent system will be used as an educational set of programs for students of higher educational institutions, as well as for bioengineers and materials scientists for scientific and production purposes. The study used Internet of Things (IoT) technologies to obtain images from optical measurement devices (electron microscope, etc.) from system users and send them the results of image analysis. By interacting the electron microscope with the created software package, the task of determining the number of all particles and the number of particles that satisfy the 3D printing algorithm was performed. Based on these data, the expert makes a decision on the possibility of using polymer particles for subsequent 3D printing. To implement the system, modern libraries of the Python programming language were used, namely Pandas, Direction2 and YOLOv5 and others.
KAPP-Sen TMC: Term Placental Tissue Collection v1
Authors: Suvakov Sonja
Published: April 2024

The placenta samples are obtained within 15 minutes after delivery. As soon as the placenta is delivered it is placed in the box at room temperature and brought to the room where the samples are collected and labelled. Approximate time needed to complete the collection is 30 minutes.
Longitudinal [18F]SynVesT-1 PET targeting SV2A in PPMI (PPMI SV2A PET Imaging) v1
Authors: Marek Kenneth
Published: April 2024

This protocol details the longitudinal [18F]SynVesT-1 PET targeting SV2A in PPMI (PPMI SV2A PET Imaging).
Wasatch Fault Structure from Machine Learning Arrival Times and High-Precision Earthquake Locations
Authors: Wells Daniel , Lomax Anthony , Baker Ben , Bartley John , Pankow Kris
Published: April 2024

On 18 March 2020, a magnitude 5.7 earthquake hit the Salt Lake valley in the state of Utah, United States. Using a dense geophone deployment and machine learning (ML), an additional several thousand events were detected and located. Currently, both the mainshock and the majority of the aftershocks are suspected to have occurred on or near a deeper portion of the Salt Lake segment of the Wasatch fault—part of a large range-bounding fault system thought to be capable of generating an Mw 7.2 earthquake. However, a small subset of aftershocks may have occurred on a portion of the more steeply, eastward dipping, and poorly understood West Valley fault. Unfortunately, the catalog locations and lack of focal mechanisms for this subset of aftershocks provide only a crude constraint on the true fault structure. To better illuminate fault structure, we relocate the ML-generated catalog with a range of magnitudes from −2 to 4.6, using: (1) NonLinLoc, a nonlinear location algorithm, (2) source-specific station terms, and (3) waveform coherence. We further compute first-motion focal mechanisms for 68 events. Results of the relocation suggest a simpler, minimally listric Wasatch fault geometry, contrary to what has been previously proposed. We also find that analysis of the focal mechanisms and waveform similarity indicates minimal event similarity throughout the Magna sequence, suggesting a highly complex and heterogeneous rupture zone, as opposed to rupture on a single plane. These findings suggest an increased seismic hazard due to the overall shallowness of the earthquake sequence and highly varied rupture mechanisms.
Seismic Magnitude Estimation Using Low-Frequency Strain Amplitudes Recorded by DAS Arrays at Far-Field Distances
Authors: Nayak Avinash , Correa Julia , Ajo-Franklin Jonathan
Published: April 2024

Downhole distributed acoustic sensing (DAS) data are now routinely acquired on fiber-optic cables deployed in wells for seismic imaging and microseismic monitoring. We develop a semiempirical workflow for estimating scalar seismic moment and moment magnitude of earthquakes using strain data recorded by downhole DAS arrays. At far-field distances, the time integral of axial strain is proportional to the displacement scaled by apparent slowness. Therefore, seismic moment can be directly estimated from the amplitude of the low-frequency plateau of the strain spectra divided by frequency, similar to the methodology commonly employed for far-field displacement spectra. The effect of polarization on strain amplitudes for different types of body waves is accounted for. Benefitting from the large spatial coverage provided by DAS arrays, moment estimates from multiple channels are averaged and an average radiation coefficient is assumed over the focal sphere. We validate the methods using data of microseismic events simultaneously recorded by a surface geophone array and by DAS on fiber deployed in two horizontal wells during a hydraulic fracturing experiment. For 106 microseismic events in the magnitude range ∼ −0.65 to ∼ +0.55, we find the DAS-derived magnitudes to be consistent with the magnitudes derived from the geophone array using traditional methods, with ∼95% of the magnitude estimates differing by less than ∼0.26 units. The workflow can be potentially extended to DAS arrays in vertical wells and to S waves recorded on dark fiber DAS arrays at the surface. This methodology does not require any calibration beyond knowledge of local seismic properties, and the use of the lowest possible frequencies reduces the influence of subsurface heterogeneities and the finite spatiotemporal extent of earthquake ruptures. The capacity to estimate robust seismic magnitudes from downhole DAS arrays allows improved evaluation and management of fracture growth and more effective mitigation of induced seismicity.
Mucocele Treatment in Pediatric Patient at RSGM UMY
Authors: Farani Wustha , Femilian Afryla , Prabawati Ayu
Published: April 2024

Background : Mucoceles is minor salivary gland lession. The extravasation mucocele, commonly referred to as a "mucous retention cyst," does not have an epithelial lining or a well-defined boundary. An extravasation mucocele is believed to be caused by damage to a tiny salivary gland excretory duct. Saliva accumulates in the adjacent submucosal tissue due to a tear in the duct, leading to swelling. Retention type mucocele occurs when a small salivary gland duct is blocked, often by a sialolith, periductal scarring, or tumor. Salivary flow blockage leads to the accumulation of saliva and the enlargement of the duct.
Objective : To provide treatment for mucocele in a pediatric patient at RSGM UMY
Case Report : A 9-year-old patient came to RSGM UMY accompanied by his mother, complain he has swelling on lower lip. He often bite the lower lip for a long time. It is painless and sometimes increases in size. His experiencing discomfort due to the bump.
Method : The mucocele was excised using infiltration anesthetic and a blade no. 15. Surgical sutured silk braided was utilized for postoperative wound closure. The patient was provided with post-operative instructions and prescribed antibiotics and analgesics. The patient was scheduled for a follow-up appointment after one week to have the sutures removed.
Result : No complaints after control 1 month and 3 months after treatment
Conclusion : Surgical removal remains the optimal choice for treating mucoceles due to its simplicity and cost-effectiveness compared to laser ablation, cryosurgery, and electrocautery
Relapse Correction with Removable Orthodontic
Authors: Wardana Puspitarini Nindya , Zulfikar Trinadya Muhammad
Published: April 2024

Relapse is when the teeth return to the position before orthodontic treatment. The small gaps between teeth often occur due to relapse conditions. A removable appliance is an orthodontic appliance that the patient can remove and insert themselves. This aims to report a relapse case treated using removable orthodontics. The case, A 26-year-old female patient complained of upper front teeth being gapped and lower front teeth being crowded. Previous dental history showed that the teeth had been treated with a fixed orthodontic appliance one year ago with premolar extraction. The patient did not use a retainer. The removable orthodontic appliance used was an active plate that retracted the maxillary anterior teeth using a labial bow. Orthodontic relapse can occur due to incomplete remodelling. Retraction using a labial bow can close the anterior teeth palatally.  Active plates can be used as an alternative treatment in mild cases of relapse after fixed orthodontic treatment
Identification of the Position of the Mental Foramen Based on Age in Patients at RSGM UMY Using Panoramic Radiography
Authors: Setyawan Erwin , Alam Dwike Rahma
Published: April 2024

The mental foramen is part of the mandible's anatomical structure, found on both sides of the mandible. Identification of the position of the mental foramen is clinically very important in dental practice, including in carrying out anesthesia, implant placement, endodontic treatment, and consideration of surgical procedures around the mental foramen to prevent damage to the nerve tissue and blood vessels that pass through the mental foramen. This study uses panoramic radiograph to determine the position of the mental foramen based on age in patients at Dental and Oral Hospital, UMY (RSGM UMY). This research is descriptive observational with a cross-sectional approach. A total of 132 mental foramen samples from RSGM UMY patients aged 12-35 years were grouped based on age of mandibular development. Data were divided into 6 groups based on the position of the mental foramen in relation to the lower jaw posterior teeth, then processed using a descriptive statistical method using Microsoft Excel. The results of this study showed that in the 12-16 year age group, the position of the mental foramen was most often found in position 3 with 21 (15.91%), while for those aged 17-25 years, it was 32 (24.24%) and for those aged 26-35 years old, 20 (15.15%) is most often found in position 4. Most mental foramen positions reviewed using panoramic radiograph at RSGM UMY were in position 4, parallel to the second premolar of the lower jaw
Predictors of husbands in supporting wives to use obstetrics care services by health professionals, Dire Dawa administration, Ethiopia: a community based cross sectional study
Authors: Yasin Aminu Mohammed , Tekle Mickiale Hailu , Asegid Daniel Tadesse , Beshir Asma Bireda , Amera Tewodros Getnet , Tefera Yibekal Manaye
Published: April 2024

Background: Husbands’ support in obstetric care services is a process of social and behavioral change that husbands must undergo to prevent obstetric complications. But so far, studies across Ethiopia have been inconsistent and lacking in the study area. Therefore, this study was aimed at assessing husbands’ predictors, which could help in interventions.
Methods: A community-based cross-sectional study was conducted in the Dire Dawa administration, Ethiopia, from July 1-30, 2022. Participants were selected using a systematic sampling technique. Data were collected through interviews using a structured questionnaire, entered into EPI data (Version 3.1), and analyzed using SPSS (Version 22). A p=0.05 or less at multivariate with 95% confidence intervals was considered statistically significant.
Results: Of a total of 610, 51.8% of husbands support wives in using obstetrics care services. The predictors were urban residence (AOR=2.55, 95% CI: 1.75-3.73), education level of diploma and above (AOR=2.00, 95%CI: 1.10-3.74), perceived importance (AOR=1.98, 95% CI: 1.30-3.00), antenatal care visit accompanying experience (AOR=1.79, 95% CI: 1.04-3.07), and institutional delivery accompanying experience (AOR=6.20, 95% CI: 3.4-1.33).
Conclusions: One in two husbands supports wives to use obstetrics care services provided by health professionals. Findings are helpful in advancing knowledge of husbands’ factors and highlight the need for health facilities and stakeholders to strengthen and create continuous community awareness.
Symmetrical acrokeratoderma: a case series
Authors: Iftikhar Swale , Gupta Anil Kumar , Rajkumar  , Singh Urjasweta
Published: April 2024

Symmetrical acrokeratoderma is rare keratinization disorder which is characterized by symmetrical acral brown to black hyperpigmented keratotic plaques. In this case series, all three patients presented with asymptomatic symmetrical thick raised dark brown skin lesions with rough surface on flexural surface of wrists and dorsum of hands and feet. Palms and soles were spared in all three patients. White maceration and swelling of skin lesions were noticed after soaking in water. All Patients showed good response to oral acitretin and patients were asked for regular follow up every 4 weekly.
Aleukemic leukemia cutis: a rare case report
Authors: Kharabanda Akshara , Singh Sudhir
Published: April 2024

Leukemia cutis is a rare case disorder characterised by infiltration of neoplastic leukocytes (myeloid or lymphoid) in clinically identifiable cutaneous lesions. It can occur before the onset of hematological presentation of leukemia or during the disease course. The lesions may be highly variable ranging from flesh coloured to violaceous papules, nodules or plaques. A 52-year-old male patient came to the Dermatology Department with multiple asymptomatic erythematous papulonodular lesions involving the face, trunk as well as the extremities from the past 6 months. Systemic examination and counts were normal. On histopathological examination diffuse dense infiltrate of neutrophils and eosinophils throughout the dermis with extension of infiltrate in the interstitium of reticular dermis. Scattered amidst the infiltrate were several large cells with abundant pale cytoplasm and irregular nuclei. Immunohistochemistry was done, radiotherapy was planned and poor prognosis was explained to the patient. The case is being reported due to its rarity and the role of dermatopathologist in early diagnosis.
Erasmus syndrome: A rare case report
Authors: Sheet Chandan Kumar , Pothal Sudarsan , Manjhi Rekha , Dutta Pravati , Chatterjee Subhankar
Published: April 2024

Erasmus syndrome is a rare clinical entity in which systemic sclerosis develops following exposure to silica with or without development of silicosis. There are very few cases reported in literature from India. Here we report a case of Erasmus syndrome in a 52 years male who is a stone crusher by occupation for last 22 years presented with dry cough, low grade irregular fever, progressive shortness of breath, slowly progressive sclerodactyly and features suggestive of Raynaud’s phenomenon. Radiological evaluations revealed multiple subpleural and centrilobular nodules in bilateral upper, lower lobes and right middle lobe, conglomerated nodular opacities (progressive massive fibrosis- PMF). There was pleural thickening and calcification, bronchial dilatation and fibrosis, calcified right hilar and mediastinal lymphadenopathy. Serological markers like Anti Scl-70 antibody came out to be positive (3+) Based on clinical features diagnosis of systemic sclerosis was made. Based on exposure history and radiology silicosis was diagnosed. Association of silicosis and systemic sclerosis establishes the diagnosis of Erasmus syndrome. Treatment was started with Prednisone, cyclophosphamide and Nifedipine. Strict avoidance to cold and regular follow-up was advised.
Depende de ti: la vida de alta presion de los futbolistas migrantes
Authors: Smoke Benjamin
Published: April 2024

Soccer is the most popular sport in the world. As a transnational sport, soccer is directly connected with migration. Although it is often highlighted as “the beautiful game,” there is a lot of ugliness in the sport that is too often overlooked and that remains uncovered. Through an analysis two films – Diamantes Negros, directed by Miguel Alcantud, and Rudo y Cursi, directed by Carlos Cuarón – this essay sheds light on some of the dark realities that migrant players experience. Migrant professional players experience a litany of challenges including familial pressure, manipulation, exploitation, isolation, and abandonment. For better and for worse, soccer also makes an impact on non-professional transnational migrants. At times soccer provides a place of community and sense of identity but at other times it provides a setting for the perpetuation for racism and the victimization of women. This essay explores these themes with the hope of starting a conversation about the harsh reality of the transnational scene of soccer that will lead to change.
Realize This Is My Space: Applying Co-Cultural Theory to the Interactions of the Deaf Community and Sign Language Interpreters
Authors: Rodriguez Dezirae
Published: April 2024

This paper explores the significance of Deaf individuals’ communicative practices and the orientation outcomes they enact when engaging with sign language interpreters through co-cultural theory. Orbe’s co-cultural theory is grounded in the idea that over time one co-culture, European-American heterosexual middle/upper class males, have acquired dominant group status in a variety of institutions (Orbe, 1998). A significant portion of research centering on co-cultural theory focuses on race, gender, and sexual orientation, and fewer studies engage with the Deaf community. Identifying the Deaf community as a co-cultural group, the researcher recruited six Deaf and hard-of-hearing participants to share their lived experiences when interacting with sign language interpreters. The interviews were analyzed, and through assessing the six universal factors that influence the process for co-cultural groups to select communicative practices, three emerged as most prevalent in their experiences: field of experience, navigating perceived risk-reward, and abilities. Based on these factors, the communication practices enacted determined the overall communication orientation. Within this study, two negotiation strategies most salient to the interactions for the co-cultural group, Deaf people, were: nonassertive assimilation and assertive accommodation.
Somewhere Only We Go
Authors: Taetz Claire
Published: April 2024

The process of writing the screenplay, Somewhere Only We Go, occurred over eight months for actress and creative Claire Kendall Taetz. From deeply researching the writing process and watching her characters come to life as she typed out her script, Taetz formed a complex psychological thriller that will have audiences questioning the layers of reality and consciousness. Logline for film: “Nearing high school graduation, Ashlynn MacGregor and her friends venture out on the town. A tragic event occurs, and Ashlynn is presented with a new reality...and the question is not can she accept it, but how she will accept it. Somewhere she goes takes us on a journey where we all go, through the eyes of one frightened but dauntless woman on the brink of insanity.
From Stage to Screen: The Digital Mediatization of Ballet
Authors: Verzywvelt Jillian
Published: April 2024

While contributing to mediatization theory by extending the scope of study, this research explores the interrelationship between digital media and ballet. Upon defining ballet as a sociocultural field, it attempts to describe how digital media influences ballet and assess: 1) how and why ballet dancers of varying degrees of involvement use different types of digital media when engaging with their activity; 2) how ballet dancers understand digital media’s influence on the development of ballet; and 3) the attitudes toward such influence that ballet dancers hold. The study first offers an outline of the history of ballet and its longstanding relationship with the media. It then provides a brief overview of mediatization and, considering the complexity of the contemporary digital media environment, isolates the influence of digital mediatization. The results suggest that digital mediatization has significantly influenced the development of ballet, affecting technical, professional, and social institutions and processes.
Rebirth: An Exploration of Circular Fashion
Authors: Satkiewicz Olivia
Published: April 2024

With increased pressure for companies within the fashion industry to implement more sustainable practices, the problem of greenwashing as a way to monetize eco-initiatives has become common among fast fashion giants. In order to make significant change and mitigate the industry’s environmental impact, the problem must be re-imagined to eliminate the very concept of waste and rather transition to a circular economy. The following research examines the concept of closed loop recycling and how sustainable practices can be implemented on a large scale. It highlights several companies that have set a precedent for the future of circular fashion as well as discusses the Cradle to Cradle model and how it translates today. The latter half outlines the process of designing a garment for the circular economy using the concepts detailed in the research portion. The final result shows how a product can be designed in a way that appeals to both the trends of the season and the circular economy by using post-production fabrics and materials to eliminate waste entirely.
Shadows in the Shape of Swan Lake
Authors: DeBellis Juliana
Published: April 2024

Swan Lake, with its rich history of productions and iconic place in culture, is easily one of the most famous ballets of all time. Each new reimagination of the popular story situates itself uniquely as a form of artistic commentary and reflection of the time and space in which it was created. Taking into consideration the historical context of the ballet as well as creative choices made in previous adaptations, I have choreographed and produced a short film adaptation of Swan Lake through the lens of authoritative censorship. The story of Swan Lake is inherently about freedom: Odette is trapped by both Rothbart’s curse and then later Siegfried’s betrayal of their love. My film follows Odette as she navigates a morally gray world in search of truth.  She encounters the Swans, a censored version of the people she knows, as well as their puppeteer, a stranger who alternates between the roles of Siegfried and Rothbart. After being tossed about this ambiguous space, Odette eventually finds reality and truth, but not without serious repercussions. With this film, I speak to the voicelessness that artists and citizens experience during times of suppression of information and speech. Furthermore, this film asks the audience: who gets their voice heard in modern media, and how is that voice and its accompanying statements interpreted and used over time?
Fort Worth After School Arts
Authors: Light Julia
Published: April 2024

This project illustrates my process of creating the curriculum for a pilot Musical Theatre program called Fort Worth After School Arts. The program is designed to address the widespread issue of a lack of arts education in low-income schools by beginning with middle schools in Fort Worth ISD, partnering with the preexisting Fort Worth After School program. Moreover, the program is designed to provide intentional accessibility efforts as well as personal development and mentorship opportunities by utilizing college-aged interns. I documented each step of the process, from the multiple factors that led me to begin to deciding what the program would look like, writing the curriculum, and receiving feedback. I also documented anticipated further challenges that would need to be addressed for the program to be fully realized. Through this project, I learned how to synthesize information from a variety of places and experiences to benefit others. This project also reinforced my view of the opportunity and necessity for innovative thinkers to create creative projects that serve communities–something I hope and plan to do for my entire career.
The Effects of Transcutaneous Auricular Vagus Nerve Stimulation on Language Retention in College-Aged Students
Authors: Crupper Jordan
Published: April 2024

As our world is becoming more globally connected, the ability to speak another language is increasingly becoming a valuable skill. While there exist many training programs to help acquire a new language, this task becomes increasingly difficult with age—thus presenting the need for a novel method of intervention to assist in this process. Considering this increasing difficulty and poor outcomes of existing methods, a new biologically based intervention could be valuable for improving learning and memory. Previous research conducted in our lab has shown that noninvasive transcutaneous auricular vagus nerve stimulation (taVNS) is an effective intervention in memory-based reading comprehension and letter-sound learning (Thakkar et al., 2020;2023). TaVNS has also been shown to boost associative memory (Jacobs et al., 2015), spatial working memory (Sun et al., 2021), and emotional memory (Ventura-Bort et al., 2021). Despite this knowledge, little is known about taVNS and its effects on long-lasting language retention. Thus, this current study explores whether transcutaneous auricular vagus nerve stimulation can improve learning and retention of vocabulary words in a new language when paired with a training routine. Typically developing college-aged individuals were recruited through an online participant pool. All individuals were screened for age, IQ, reading, memory, and attention for inclusion in this study. The participants completed a one-hour training session in which they were presented with 30 Palauan nouns, the respective English translations, as well as images of the nouns. During this time, the participants received sham, 5 Hz, or 25 Hz stimulation to the posterior of the left tragus. Prior to training, participants completed a translation test to measure their existing knowledge of the Palauan language, and this test was repeated immediately after training and again seven days later to measure learning and retention. After analysis of the results, no effect was found for any stimulation group immediately after training. At retention, however, the 25 Hz taVNS group showed significantly greater performance than both the sham and 5 Hz taVNS groups on recall of material. There was also no statistical difference between the performance of the sham and 5 Hz taVNS groups. Lastly, the results further suggest that stimulation intensity does not impact the efficacy of the intervention. These data suggest that taVNS, regardless of stimulation intensity, may be used to help in the retention of novel words in a new language. These data will be important for ongoing research examining the uses of taVNS, its use as an intervention for learning and retention of a new language, as well as its potential uses in other areas of cognition.
The Local Financial Impact of the Paycheck Protection Program: County Level Determinants
Authors: Singhal Divyanshi
Published: April 2024

The Paycheck Protection Program (PPP) was one of the key components of the government’s response to the economic fallout of COVID-19. Enacted on March 27, 2020, the program had ambitious goals that included keeping workers off the unemployment rolls, boosting consumer spending, and ensuring small business continuity during the shutdown. Nonetheless, empirical evidence on the success of PPP is mixed. In order to contribute to this literature, I examine the impact of PPP loans on unemployment and consumer spending at the county level. Congress amended the PPP in 2021 by passing the Economic Aid to Hard-Hit Small Businesses, Nonprofits, and Venues Act (Economic Aid Act), which was intended to provide additional support to many small businesses. Since most of the existing studies are limited to 2020, I study PPP loans disbursed in both 2020 (pre-Economic Aid Act) and 2021 (post-Economic Aid Act). My study addresses the following three economic questions:
      i.        Did the Paycheck Protection Program result in lower unemployment rates in participating counties? 
     ii.        Did the Paycheck Protection Program stimulate consumer spending in participating counties? 
     iii.       Was aid given in 2021 through the Economic Aid Act more effective than the initial 2020 Paycheck Protection Program? 
Through pooled ordinary least squares (OLS) and fixed effects regressions, I find that the counties that received PPP loans experienced a decrease in unemployment rates and an increase in consumer spending. Additionally, my analysis indicates increased effectiveness of the PPP loans in 2021 relative to 2020. Overall, my analysis indicates that the PPP achieved its objectives.
Jałowymi ideami intelektualista się nie pożywi… Profesor Ryszard Panasiuk o swojej drodze naukowej, warszawskiej szkole historii idei i marksistowskiej utopii
Authors: Piskała Kamil
Published: April 2024

Profesor Ryszard Panasiuk przez ostatnich kilka dekad należał do grona wiodących polskich filozofów. Jego książki na temat Hegla, ruchu młodoheglowskiego czy Marksa należą do kanonu historiografii idei. Publikowany tutaj obszerny wywiad z Profesorem może stanowić wartościowe i oryginalne źródło do historii inteligencji i humanistyki w tzw. Polsce Ludowej. Profesor Panasiuk opowiada w nim o swojej karierze naukowej, jednocześnie kreśląc obraz przemian akademickiego środowiska filozoficznego w powojennej Polsce. Wiele uwagi poświęca również swojej relacji z Bronisławem Baczką i innymi wybitnym reprezentantami Warszawskiej Szkoły Historii Idei. Ponadto Profesor analizuje proces narastania prądów dysydenckich wśród zwolenników marksizmu po Październiku ’56 i wyjaśnia ostateczny rozkład post-stalinowskiej ortodoksji w polskim życiu intelektualnym tego okresu. Jak również dowodzi, że choć Marks stanowi ważny i wciąż warty badania rozdział w historii filozofii europejskiej, to marksizm, z uwagi na zawarty w nim koncept „radykalnej wspólnoty”, jest ideologią z gruntu utopijną.
Mowa przetokowa – standard postępowania logopedycznego u osób po implantacji zastawki tchawiczo-przełykowej
Authors: Hamerlińska Agnieszka
Published: April 2024

The text describes the treatment methods used in people with advanced larynx cancer. In the article has been described a voice prosthesis implanted after surgical removal of the larynx. The resulting speech is a tracheoesophageal fistula with insertion of vocal prosthesis. Tracheoesophageal fistula and esophageal speech were compared by analyzing the literature. The purpose of the text is to present the standard of speech therapy in patients after total laryngectomy, in whom the tracheoesophageal vocal prosthesis was implanted.
Sprawność komunikacyjna osób z głęboką niepełnosprawnością intelektualną
Authors: Chilińska-Pułkowska Alicja
Published: April 2024

The article has characterised the functioning at the level of communication efficiency of persons with profound intellectual disabilities in speach act and reception. The results of the studies, based on available diagnostic tools to help extract communication channels, form, thematic scope and the way messages are transmitted, are taken into account. Final analysis gives an image most of the communication behaviour forms which can be observed in a child with profound disability. Without undermining the need of individualisation of the diagnostic process of communication skills, the data obtained can be illustrative and focus therapists’ attention on specific signals which can be interpreted as communicative. Further interpretation of them always depends on the personal characteristics, situations, capabilities and preferences a person under charge. The subject considered in this article is the begining of a therapist’s path, including the speech therapist in improving the ability to communicate with a child with special communication needs. Creating a reliable diagnosis allows you to introduce actions that minimize lack of speech and present other effective forms of communication. It is the basis for introducing AAC actions which allow you to establish clear and relatively satisfying relationship with children and for them it will be helpful in expressing their needs and understanding the reality.