bluuebunny/crossref_metadata_2025 huggingface dataset:
Stress and Deformation Analysis of Prestressed Wound Composite Components with an Arch-Shaped Metal Liner
Authors: Wang Junsheng , Xiao Jun , Huan Dajun , Yan Lei , Wang Zijie , Tao Zhiwei
Published: February 2024

The stress distribution in prestressed filament wound components plays a crucial role in determining the quality of these components during their operational lifespan. This article proposes a physical model to analyze the stress and deformation of prestressed wound composite components with arch-shaped sections. Drawing upon the principles of beam theory, we delve into the analysis of prestressed wound components with metal liners featuring arch-shaped sections. Our investigation revealed a noteworthy phenomenon termed the “additional bending moment effect” within prestressed wound components with arch-shaped sections. Furthermore, this study establishes a relationship between this additional bending moment and the external pressure. In addition, a 3D finite element (FE) model for prestressed wound components with arch-shaped sections incorporating metal liners was developed. The model’s accuracy was validated through a comparison with prestressed wound experiments, showcasing an error margin of less than 2%. In comparison with prestressed wound components with circular cross-sections under identical load and dimensional parameters, it was observed that prestressed wound components with arch-shaped sections exhibit stress distributions in the arc segments akin to their circular counterparts, with differences not exceeding 5%. Notably, when the ratio of the straight segment length to the inner diameter of the arc segment inner is less than 4, the deformation on the symmetric plane of the arc segment in an arch-shaped component can be effectively considered as the summation of deformations in equivalent-sized arc and straight segments under identical loading conditions. This yields an equivalent physical model and a streamlined analysis and design methodology for describing the deformation characteristics of prestressed wound components with arch-shaped sections.
Microcapsule Triggering Mechanics in Cementitious Materials: A Modelling and Machine Learning Approach
Authors: Ricketts Evan John , de Souza Lívia Ribeiro , Freeman Brubeck Lee , Jefferson Anthony , Al-Tabbaa Abir
Published: February 2024

Self-healing cementitious materials containing microcapsules filled with healing agents can autonomously seal cracks and restore structural integrity. However, optimising the microcapsule mechanical properties to survive concrete mixing whilst still rupturing at the cracked interface to release the healing agent remains challenging. This study develops an integrated numerical modelling and machine learning approach for tailoring acrylate-based microcapsules for triggering within cementitious matrices. Microfluidics is first utilised to produce microcapsules with systematically varied shell thickness, strength, and cement compatibility. The capsules are characterised and simulated using a continuum damage mechanics model that is able to simulate cracking. A parametric study investigates the key microcapsule and interfacial properties governing shell rupture versus matrix failure. The simulation results are used to train an artificial neural network to rapidly predict the triggering behaviour based on capsule properties. The machine learning model produces design curves relating the microcapsule strength, toughness, and interfacial bond to its propensity for fracture. By combining advanced simulations and data science, the framework connects tailored microcapsule properties to their intended performance in complex cementitious environments for more robust self-healing concrete systems.
Development and Characterisation of Composites Prepared from PHBV Compounded with Organic Waste Reinforcements, and Their Soil Biodegradation
Authors: Furgier Valentin , Root Andrew , Heinmaa Ivo , Zamani Akram , Åkesson Dan
Published: February 2024

Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a biobased and biodegradable polymer. This polymer is considered promising, but it is also rather expensive. The objective of this study was to compound PHBV with three different organic fillers considered waste: human hair waste (HHW), sawdust (SD) and chitin from shrimp shells. Thus, the cost of the biopolymer is reduced, and, at the same time, waste materials are valorised into something useful. The composites prepared were characterised by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), tensile strength and scanning electron micrograph (SEM). Tests showed that chitin and HHW did not have a reinforcing effect on tensile strength while the SD increased the tensile strength at break to a certain degree. The biodegradation of the different composites was evaluated by a soil burial test for five months. The gravimetric test showed that neat PHBV was moderately degraded (about 5% weight loss) while reinforcing the polymer with organic waste clearly improved the biodegradation. The strongest biodegradation was achieved when the biopolymer was compounded with HHW (35% weight loss). The strong biodegradation of HHW was further demonstrated by characterisation by Fourier-transform infrared spectroscopy (FTIR) and solid-state nuclear magnetic resonance (NMR). Characterisation by SEM showed that the surfaces of the biodegraded samples were eroded.
Experimental Study and Application of Controlled Low-Strength Materials in Trench Backfilling in Suqian City, China
Authors: Xu Jingmin , Luo Qiwu , Tang Yong , Zeng Zhibo , Liao Jun
Published: February 2024

When backfilling narrow spaces, controlled low-strength materials (CLSM) can be used to achieve an effective backfilling effect. The pipeline engineering in Yahnghe Avenue of Suqian, China, provides a favorable on-site condition for the use of CLSM. However, no guidance exists for the determination of the material mixture ratio of CLSM for this geological condition. Laboratory tests were performed to investigate the basic physical parameters of excavated soil and the optimal mixture ratio of CLSM. Results indicate that the sand and silt account for 29.76% and 57.23% of the weight of excavated soil, respectively. As the water content increases (from 40% to 50%), the flowability of the CLSM approximately shows a linear increase (slumps values from 154.3 mm to 269.75 mm for 9% cement content), while its compressive strength shows a linear decreasing trend (from 875.3 KPa to 468.3 KPa after curing for 28 days); as the cement content increases (from 6% to 12%), the flowability approximately shows a linear decreasing trend (from 238.8 mm to 178.5 mm for 45% water content), while the compressive strength shows a linear increasing trend (from 391.6 KPa to 987.6 KPa after curing for 28 days). By establishing the relationship between compressive strength/flowability and the water–cement ratio, the optimal material ratio is determined to be 9% cement content and 40–43% water content. The engineering application results indicate that the use of CLSM can achieve efficient and high-quality backfilling effects for pipeline trenches. The findings of this research may provide a reference for the application of CLSM in fields with similar geological conditions.
Review on Design, Characterization, and Prediction of Performance for Asphalt Materials and Asphalt Pavement Using Multi-Scale Numerical Simulation
Authors: Wang Wentao , Wang Linbing
Published: February 2024

Asphalt pavement, which is mainly made up of the asphalt mixture, exhibits complicated mechanical behaviors under the combined effects of moving vehicle loads and external service environments. Multi-scale numerical simulation can well characterize behaviors of asphalt materials and asphalt pavement, and the essential research progress is systematically summarized from an entire view. This paper reviews extensive research works concerning aspects of the design, characterization, and prediction of performance for asphalt materials and asphalt pavement based on multi-scale numerical simulation. Firstly, full-scale performance modeling on asphalt pavement is discussed from aspects of structural dynamic response, structural and material evaluation, and wheel–pavement interaction. The correlation between asphalt material properties and pavement performance is also analyzed, and so is the hydroplaning phenomenon. Macro- and mesoscale simulations on the mechanical property characterization of the asphalt mixture and its components are then investigated, while virtual proportion design for the asphalt mixture is introduced. Features of two-dimensional and three-dimensional microscale modeling on the asphalt mixture are summarized, followed by molecular dynamics simulation on asphalt binders, aggregates, and their interface, while nanoscale behavior modeling on asphalt binders is presented. Finally, aspects that need more attention concerning this study’s topic are discussed, and several suggestions for future investigations are also presented.
Comparison of Measured and Calculated Porosity Parameters of Woven Fabrics to Results Obtained with Image Analysis
Authors: Zupin Živa , Štampfl Veronika , Kočevar Tanja Nuša , Gabrijelčič Tomc Helena
Published: February 2024

Porosity, the measure of the open spaces within a fabric structure, is a decisive factor in the performance of textiles. It influences breathability, permeability to liquids or gases, and suitability for various industries such as apparel, medical, and technical textiles. This study compares classical porosity calculation methods with non-destructive image analysis for 24 woven fabric samples that differ in density and weave pattern. Factors such as fabric density, weave pattern, illumination conditions, magnification, and the influence of the Otsu and Yen threshold algorithms were considered. The multifactor ANOVA statistical analysis shows that fabric density and weave pattern significantly influence porosity, with illumination playing an important role, while the threshold algorithm has a minor influence. A strong correlation is found between the actual fabric porosity and the results of the image analysis, except for double-sided illumination (reflective and transmissive), where the correlation is weakest. This comprehensive investigation provides valuable insights into the reliability of different porosity assessment approaches, which is essential for applications in various textile industries.
Dynamic Adsorption of a Cationic Dye onto Wool Fibers as Column-Filling Media: Response Surface Optimization and Fixed-Bed Adsorption Modeling
Authors: Condurache Bogdan-Constantin , Cojocaru Corneliu , Bargan Alexandra , Samoila Petrisor , Harabagiu Valeria
Published: February 2024

This study reports a simple and low-cost method for water purification using recyclable natural fibers (coarse wool fibers) as column-filling media for adsorption in the dynamic mode. As an instance of a dissolved organic pollutant, a cationic dye (basic blue 9, BB9) was assayed. According to the Langmuir isotherm (recorded at 300 K), the calculated maximum adsorption capacity of the fibrous material was found to be 24.86 mg/g for the retention of BB9. Response surface methodology (RSM) was employed for the design of experiments and the model-based optimization of the adsorption process performed in the dynamic regime (fixed-bed column). The optimal conditions provided by RSM indicated an adsorbent column height of H = 13.5 cm and a feed flow rate of Fv = 3 mL/min; these operating parameters ensured a color removal efficiency of 92.56% after 240 min of contact time. The recorded breakthrough curve under the optimal conditions was further interpolated using five quantitative mathematical models (Adams–Bohart, Thomas, Yoon–Nelson, Yan, and Clark) to assess the dynamic behaviors in the fixed-bed column. The best goodness-of-fit was achieved for the Thomas and Yoon–Nelson models. Thus, the coarse wool fibers used in a fixed bed demonstrated a relevant efficiency in the removal of cationic organic pollutants from contaminated water.
Oleaginous Microbial Lipids’ Potential in the Prevention and Treatment of Neurological Disorders
Authors: Alhattab Mariam , Moorthy Lakshana S. , Patel Durva , Franco Christopher M. M. , Puri Munish
Published: February 2024

The products of oleaginous microbes, primarily lipids, have gained tremendous attention for their health benefits in food-based applications as supplements. However, this emerging biotechnology also offers a neuroprotective treatment/management potential for various diseases that are seldom discussed. Essential fatty acids, such as DHA, are known to make up the majority of brain phospholipid membranes and are integral to cognitive function, which forms an important defense against Alzheimer’s disease. Omega-3 polyunsaturated fatty acids have also been shown to reduce recurrent epilepsy seizures and have been used in brain cancer therapies. The ratio of omega-3 to omega-6 PUFAs is essential in maintaining physiological function. Furthermore, lipids have also been employed as an effective vehicle to deliver drugs for the treatment of diseases. Lipid nanoparticle technology, used in pharmaceuticals and cosmeceuticals, has recently emerged as a biocompatible, biodegradable, low-toxicity, and high-stability means for drug delivery to address the drawbacks associated with traditional medicine delivery methods. This review aims to highlight the dual benefit that lipids offer in maintaining good health for disease prevention and in the treatment of neurological diseases.
A Multilevel Analysis of Changes in Psychological Demands over Time on Employee Burnout
Authors: Parent-Lamarche Annick , Marchand Alain , Saade Sabine
Published: February 2024

In pursuing this study, we were interested in the effect of changes in psychological demands over time on burnout. We were also interested in examining the moderating role resources could play between changes in job demands over time and employee burnout. Multilevel regression analyses of repeated measures were conducted to capture the hierarchical structure of the data (time (Level 1, n = 537 (12-month period between T1 and T2)); employees (Level 2, n = 289)) nested in firms (Level 3, n = 34). To measure change in psychological demands, the distribution of psychological demands at T1 and T2 were dichotomized at the T1 median. Following this dichotomization, four groups were created: low T1 and low T2; high T1 and low T2; low T1 and high T2, high T1 and high T2. In terms of direct associations, an increase in psychological demands over time was associated with emotional exhaustion and cynicism but not professional efficacy. Locus of control, self-esteem, and social support from supervisors were also directly associated with burnout. As for interaction effects, social support from coworkers attenuated the effect of changes in psychological demands over time (i.e., increasing psychological demands) on cynicism. In other words, employees facing greater psychological demands over time (increasing psychological demands) and benefitting from social support from their coworkers had less cynicism. Our findings offer meaningful insights into possible ways of lowering burnout levels. Based on the results obtained, psychological demands, social support, locus of control, and self-esteem should be considered valuable intervention targets.
Effects of Fe Contents on the Microstructure and Precipitate of Ti–Al–V Alloys Prepared by Direct Energy Deposition
Authors: He Zijian , Yang Wanwan , Liu Cheng , Wei Xiao , Wang Jiangwei
Published: February 2024

This study investigated the influence of Fe content on the microstructure and mechanical properties of Ti–6Al–4V(TC4) + 25Ti alloys prepared by low-energy-density direct energy deposition (DED) technology. With the incorporation of the Fe elements, the α-Ti phases exhibited significant changes in size and morphology, while the numerous β-Ti phases and some triclinic-Ti precipitates were retained. With the refinement of the α-Ti phase, retainment of the β-Ti phase and the presence of triclinic-Ti precipitates, the mechanical properties of DED samples can be significantly improved compared with DED TC4 alloys. The room-temperature mechanical property tests showed that the ultimate tensile strength (UTS) of 3Fe + TC4 + 25Ti achieved 1298.64 ± 5.26 MPa with an elongation of 4.82% ± 0.20%, and the maximum elongation of 1Fe + TC4 + 25Ti reached 10.82% ± 0.82% with a UTS of 1076.95 ± 11.69 MPa. The strengthening mechanism of DED Ti-Al-V-Fe alloys were further discussed, providing new insights into the microstructure control and the composition design of additive manufacturing of Ti alloys.
Metabolomic Profiling of Blood Plasma in Females with Hyperplasia and Endometrial Cancer
Authors: Benabdelkamel Hicham , Jaber Malak A. , Akkour Khalid , AlMalki Reem H. , Alfadda Assim A. , Masood Afshan , Joy Salini Scaria , Alhalal Hani , Alwehaibi Moudi A. , Arafah Maria , Alshehri Eman , Abdel Rahman Anas M.
Published: February 2024

Uterine cancer is the most prevalent gynecologic malignancy in women worldwide. Endometrial cancer (EC) has an 81% five-year survival rate, depending on disease stage and time of diagnosis. While endometrial cancer is largely treatable when detected early, no established screening techniques are available in clinical practice. As a result, one of the most significant issues in the medical field is the development of novel ways for early cancer identification, which could boost treatment success rates. Liquid chromatography–high-resolution mass spectrometry (LC-HRMS)-based metabolomics was employed to explore the metabolomic markers and pathways unique to this cancer type and link them to the benign endometrial hyperplasia that may progress to cancer in 5% to 25% of patients. The study involved 59 postmenopausal participants, 20 with EC type 1, 20 with benign hyperplasia, and 19 healthy participants. Metabolite distribution changes were analyzed, and 338 of these features were dysregulated and significant. The first two main components, PC1 and PC2, were responsible for 11.5% and 12.2% of the total metabolites, respectively. Compared with the control group (CO), EC samples had 203 differentially expressed metabolites (180 upregulated and 23 downregulated); in hyperplasia (HP), 157 metabolites were dysregulated (127 upregulated and 30 downregulated) compared to the CO group while 21 metabolites exhibited differential regulation (16 upregulated and 5 downregulated) in EC plasma samples compared to the HP group. Hyperplasia samples exhibited similar metabolic changes to those reported in cancer, except for alterations in triglyceride levels, 7a,12 b-dihydroxy-5b-Cholan-24-oic acid, and Hept-2-enedioyl carnitine levels. The metabolites N-heptanoyl glycine and -(Methylthio)-2,3-isopentyl phosphate and formimino glutamic acid can be specific markers for hyperplasia conditions and dimethyl phosphatidyl ethanolamine and 8-isoprostaglandin E2 can be specific markers for EC conditions. Metabolic activities rely on mitochondrial oxidative phosphorylation for energy generation. The changes in metabolites identified in our study indicate that endometrial cancer cells adopt alternative strategies to increase energy production to meet the energy demand, thereby supporting proliferation.
Femtosecond Laser-Induced Phase Transformation on Single-Crystal 6H-SiC
Authors: Quan Hongsheng , Wang Ruishi , Ma Weifeng , Wu Zhonghuai , Qiu Lirong , Xu Kemi , Zhao Weiqian
Published: February 2024

Silicon carbide (SiC) is widely used in many research fields because of its excellent properties. The femtosecond laser has been proven to be an effective method for achieving high-quality and high-efficiency SiC micromachining. In this article, the ablation mechanism irradiated on different surfaces of 6H-SiC by a single pulse under different energies was investigated. The changes in material elements and the geometric spatial distribution of the ablation pit were analyzed using micro-Raman spectroscopy, Energy Dispersive Spectrum (EDS), and an optical microscope, respectively. Moreover, the thresholds for structural transformation and modification zones of 6H-SiC on different surfaces were calculated based on the diameter of the ablation pits created by a femtosecond laser at different single-pulse energies. Experimental results show that the transformation thresholds of the Si surface and the C surface are 5.60 J/cm2 and 6.40 J/cm2, corresponding to the modification thresholds of 2.26 J/cm2 and 2.42 J/cm2, respectively. The Raman and EDS results reveal that there are no phase transformations or material changes on different surfaces of 6H-SiC at low energy, however, decomposition and oxidation occur and then accumulate into dense new phase material under high-energy laser irradiation. We found that the distribution of structural phase transformation is uneven from the center of the spot to the edge. The content of this research reveals the internal evolution mechanism of high-quality laser processing of hard material 6H-SiC. We expect that this research will contribute to the further development of SiC-based MEMS devices.
Dynamic Modeling for Chatter Analysis in Micro-Milling by Integrating Effects of Centrifugal Force, Gyroscopic Moment, and Tool Runout
Authors: Liu Xiaoli , Liu Dexuan , Du Canyang , Li Yang , Wang Caidong , Fu Zhijun
Published: February 2024

During micro-milling, regenerative chatter will decrease the machining accuracy, destabilize the micro-milling process, shorten the life of the micro-mill, and increase machining failures. Establishing a mathematical model of chatter vibration is essential to suppressing the adverse impact of chatter. The mathematical model must include the dynamic motions of the cutting system with the spindle–holder–tool assembly and tool runout. In this study, an integrated model was developed by considering the centrifugal force induced by rotational speeds, the gyroscopic effect introduced by high speeds, and the tool runout caused by uncertain factors. The tool-tip frequency-response functions (FRFs) obtained by theoretical calculations and the results predicted by simulation experiments were compared to verify the developed model. And stability lobe diagrams (SLDs) and time-domain responses are depicted and analyzed. Furthermore, experiments on tool-tip FRFs and micro-milling were conducted. The results validate the effectiveness of the integrated model, which can calculate the tool-tip FRFs, SLDs, and time responses to analyze chatter stability by considering the centrifugal force, gyroscopic effect, and tool runout.
Investigation and Modeling of the Behavior of Temperature Characteristics of 0.3–1.1 GHz Complementary Metal Oxide Semiconductor Class-A Broadband Power Amplifiers
Authors: Li Ruiliang , Zhou Shaohua , Yang Cheng , Wang Jian
Published: February 2024

A power amplifier (PA) stands as a central module within the electronic information system (EIS), and any variation in a PA’s specifications has a direct impact on the EIS’s performance, especially in the face of temperature fluctuations. In examining the influence of PA specification changes on the EIS, we employed support vector machine (SVM) to model the behavior of the temperature characteristics of 0.3–1.1 GHz complementary metal oxide semiconductor (CMOS) class-A broadband PAs. The results show that the parameters of S11, S12, S21, and S22 can be effectively modeled. SVM outperforms Elman and GRNN in terms of combined modeling time and modeling accuracy. This research can be extended to modeling the behavior of other types of power amplifiers or devices and circuits.
Désorite, Pb2(Fe3+6Zn)O2(PO4)4(OH)8, a New Phosphate Mineral Isotypic with Jamesite
Authors: Kampf Anthony R. , Möhn Gerhard , Ma Chi
Published: February 2024

The new mineral désorite, Pb2(Fe3+6Zn)O2(PO4)4(OH)8, is a secondary oxidation-zone mineral discovered on the dumps of the Schöne Aussicht mine, Dernbach, Westerwaldkreis, Rhineland-Palatinate, Germany. The crystals are irregular blades up to about 0.25 mm long, occurring in subparallel and radial aggregates. Désorite is brownish red. It has an orange streak, adamantine luster, brittle tenacity, splintery and curved fracture and two cleavages: {021¯} perfect and {001} good. It has a hardness (Mohs) of about 3 and is nonfluorescent in both long- and short-wave ultraviolet illumination. The calculated density is 4.633 g/cm3. Optically, crystals are biaxial (+) with α = 2.00(1), β = 2.02(calc) and γ = 2.10(calc) (white light). The 2V is 54(2)° and the optical orientation is Y ~⊥{021¯}, X ∧ a ≈ 13°. The mineral is pleochroic: X yellow brown, Y red brown, Z red brown; X < Y ≈ Z. The empirical formula from electron microprobe analysis is Pb1.93(Zn0.50Fe3+6.29☐0.21)Σ7.00(P3.90As0.10)Σ4.00O26H8.28. Désorite is triclinic, space group P1¯; the unit-cell parameters are a = 5.4389(7), b = 9.3242(13), c = 10.0927(12) Å, α = 109.024(8), β = 90.521(6), γ = 97.588(7)°, V = 478.90(11) Å3 and Z = 1. Désorite has a framework structure (R1 = 0.0487 for 937 I > 2σI reflections) assembled from Fe3+O6 octahedra and PO4 tetrahedra, with Pb occupying cavities in the framework. The Fe3+O6 octahedra in the framework occur in edge-sharing chains, edge-sharing trimers and individual octahedra, all sharing corners with each other and with PO4 tetrahedra. Désorite is isostructural with jamesite and lulzacite.
Research on the Strength Damage and Permeability Characteristics of Cemented Paste Backfill under Chlorine Salt Erosion and Dry–Wet Cycles
Authors: Li Hao , Wang Hongjiang , Bai Longjian
Published: February 2024

Cement paste backfill (CPB) suffers serious damage and deterioration under the dual erosion conditions of the dry–wet cycle caused by the high chloride salt concentration in mine water and the fluctuation of mine water level. In order to discuss the mechanical properties and permeability characteristics of CPB under erosion, this study designs an immersion experiment for CPB under chloride salt and dry–wet cycle conditions. Through a uniaxial compressive strength (UCS) test, the change law for the mechanical parameters of the CPB was investigated, the strength constitutive equation of the CPB was constructed and the deterioration process of the CPB was analyzed. The penetration test was used to investigate the diffusion characteristics of the packing under chloride salt and dry–wet cycle conditions. The results showed that the strength and Young’s modulus of the CPB initially increased and then rapidly decreased, with maximum decrease rates of 32.2% and 38.2%, respectively. The CPB structure exhibits an initial undamaged stage, an initial damaged stage, a damaged development stage, a damaged destruction stage and a residual damaged stage. The chloride ion penetration depth gradually increased with the number of dry–wet cycles, with a maximum diffusion depth of 20.5 mm. The maximum apparent diffusion coefficient of chloride ion was 18.99 × 10−10 m2/s, and the maximum concentration was 0.303 mol/L. Under the double erosion conditions of chloride salt and dry–wet cycle, the CPB structure was severely damaged.
Construction of Porphyrin-Based Bimetallic Nanomaterials with Photocatalytic Properties
Authors: Ji Zhiqiang , Yuan Mengnan , He Zhaoqin , Wei Hao , Wang Xuemin , Song Jianxin , Jiang Lisha
Published: February 2024

The efficient synthesis of nanosheets containing two metal ions is currently a formidable challenge. Here, we attempted to dope lanthanide-based bimetals into porphyrin-based metal-organic skeleton materials (MOFs) by microwave-assisted heating. The results of the EDX, ICP, and XPS tests show that we have successfully synthesized porphyrin-based lanthanide bimetallic nanosheets (Tb-Eu-TCPP) using a household microwave oven. In addition, it is tested and experimentally evident that these nanosheets have a thinner thickness, a larger BET surface area, and higher photogenerated carrier separation efficiency than bulk porphyrin-based bimetallic materials, thus exhibiting enhanced photocatalytic activity and n-type semiconductor properties. Furthermore, the prepared Tb-Eu-TCPP nanomaterials are more efficient in generating single-linear state oxygen under visible light irradiation compared to pristine monometallic nanosheets due to the generation of bimetallic nodes. The significant increase in catalytic activity is attributed to the improved separation and transfer efficiency of photogenerated carriers. This study not only deepens our understanding of lanthanide bimetallic nanosheet materials but also introduces an innovative approach to improve the photocatalytic performance of MOFs.
Wheat Bread Enriched with House Cricket Powder (Acheta domesticus L.) as an Alternative Protein Source
Authors: Gantner Magdalena , Sadowska Anna , Piotrowska Anna , Kulik Klaudia , Sionek Barbara , Kostyra Eliza
Published: February 2024

The house cricket (Acheta domesticus L.) is one of four edible insect species introduced to the EU market as a novel food and alternative protein source. Innovative products, such as cricket flour, are increasingly appearing on supermarket shelves and can offer an alternative to traditional cereals, while providing the body with many valuable nutrients of comparable quality to those found in meat and fish. The aim of this study was to investigate the possibility of using cricket powder as a substitute for wheat flour in the production of bread. The physicochemical properties of cricket powder were evaluated in comparison to wheat flour. As a result of technological studies, bread compositions with 5%, 10% and 15% replacements of wheat flour by cricket powder were designed and their quality characteristics (physicochemical, sensory and microbiological) were evaluated. Cricket powder was characterised by a higher protein (63% vs. 13.5%) and fat (16.3% vs. 1.16%) content and a lower carbohydrate (9.8% vs. 66%) and fibre (7.8% vs. 9.5%) content as compared to wheat flour. The tested preparations had a similar pH (6.9 and 6.8, respectively, for cricket powder and flour) and fat absorption capacity (0.14 vs. 0.27 g oil/g powder, respectively, for cricket powder and flour) but different water holding capacities and completely different colour parameters. All breads had good microbiological quality after baking and during 7 days of storage. In instrumental tests, the 10 and 15% replacements of wheat flour by cricket powder affected the darker colour of the breads and caused a significant increase in the hardness of the breads. The research has shown that the optimal level of replacement, which does not significantly affect the physiochemical and sensory characteristics, is 5% cricket powder in the bread recipe. Considering the results obtained and the fact that insects provide a sufficient supply of energy and protein in the human diet, are a source of fibre, vitamins and micronutrients, and have a high content of monounsaturated and polyunsaturated fatty acids, the suitability of cricket powder for protein enrichment of bakery products is confirmed.
Keto-Adamantane-Based Macrocycle Crystalline Supramolecular Assemblies Showing Selective Vapochromism to Tetrahydrofuran
Authors: Li Zunhua , Tan Yingzi , Ding Manhua , Tang Linli , Zeng Fei
Published: February 2024

Here, we report the synthesis of adamantane-based macrocycle 2 by combining adamantane building blocks with π-donor 1,3-dimethoxy-benzene units. An unpredictable keto-adamantane-based macrocycle 3 was obtained by the oxidation of 2 using DDQ as an oxidant. Moreover, a new type of macrocyclic molecule-based CT cocrystal was prepared through exo-wall CT interactions between 3 and DDQ. The cocrystal material showed selective vapochromism behavior towards THF, specifically, among nine volatile organic solvents commonly used in the laboratory. Powder X-ray diffraction; UV-Vis diffuse reflectance spectroscopy; 1H NMR; and single crystal X-ray diffraction analyses revealed that color changes are attributed to the vapor-triggered decomplexation of cocrystals.
The Role of the PTEN Tumor Suppressor Gene and Its Anti-Angiogenic Activity in Melanoma and Other Cancers
Authors: Maphutha Jacqueline , Twilley Danielle , Lall Namrita
Published: February 2024

Human malignant melanoma and other solid cancers are largely driven by the inactivation of tumor suppressor genes and angiogenesis. Conventional treatments for cancer (surgery, radiation therapy, and chemotherapy) are employed as first-line treatments for solid cancers but are often ineffective as monotherapies due to resistance and toxicity. Thus, targeted therapies, such as bevacizumab, which targets vascular endothelial growth factor, have been approved by the US Food and Drug Administration (FDA) as angiogenesis inhibitors. The downregulation of the tumor suppressor, phosphatase tensin homolog (PTEN), occurs in 30–40% of human malignant melanomas, thereby elucidating the importance of the upregulation of PTEN activity. Phosphatase tensin homolog (PTEN) is modulated at the transcriptional, translational, and post-translational levels and regulates key signaling pathways such as the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) and mitogen-activated protein kinase (MAPK) pathways, which also drive angiogenesis. This review discusses the inhibition of angiogenesis through the upregulation of PTEN and the inhibition of hypoxia-inducible factor 1 alpha (HIF-1-α) in human malignant melanoma, as no targeted therapies have been approved by the FDA for the inhibition of angiogenesis in human malignant melanoma. The emergence of nanocarrier formulations to enhance the pharmacokinetic profile of phytochemicals that upregulate PTEN activity and improve the upregulation of PTEN has also been discussed.
Early Diagnosis of Neurodegenerative Diseases: What Has Been Undertaken to Promote the Transition from PET to Fluorescence Tracers
Authors: Bisi Nicolò , Pinzi Luca , Rastelli Giulio , Tonali Nicolò
Published: February 2024

Alzheimer’s Disease (AD) and Parkinson’s Disease (PD) represent two among the most frequent neurodegenerative diseases worldwide. A common hallmark of these pathologies is the misfolding and consequent aggregation of amyloid proteins into soluble oligomers and insoluble β-sheet-rich fibrils, which ultimately lead to neurotoxicity and cell death. After a hundred years of research on the subject, this is the only reliable histopathological feature in our hands. Since AD and PD are diagnosed only once neuronal death and the first symptoms have appeared, the early detection of these diseases is currently impossible. At present, there is no effective drug available, and patients are left with symptomatic and inconclusive therapies. Several reasons could be associated with the lack of effective therapeutic treatments. One of the most important factors is the lack of selective probes capable of detecting, as early as possible, the most toxic amyloid species involved in the onset of these pathologies. In this regard, chemical probes able to detect and distinguish among different amyloid aggregates are urgently needed. In this article, we will review and put into perspective results from ex vivo and in vivo studies performed on compounds specifically interacting with such early species. Following a general overview on the three different amyloid proteins leading to insoluble β-sheet-rich amyloid deposits (amyloid β1–42 peptide, Tau, and α-synuclein), a list of the advantages and disadvantages of the approaches employed to date is discussed, with particular attention paid to the translation of fluorescence imaging into clinical applications. Furthermore, we also discuss how the progress achieved in detecting the amyloids of one neurodegenerative disease could be leveraged for research into another amyloidosis. As evidenced by a critical analysis of the state of the art, substantial work still needs to be conducted. Indeed, the early diagnosis of neurodegenerative diseases is a priority, and we believe that this review could be a useful tool for better investigating this field.
Improved Process for the Continuous Acylation of 1,3-Benzodioxole
Authors: Pollon Davide , Annunziata Francesca , Paganelli Stefano , Tamborini Lucia , Pinto Andrea , Fabris Sabrina , Baldo Maria Antonietta , Piccolo Oreste
Published: February 2024

The acylation of 1,3-benzodioxole was studied in a continuous process using a recyclable heterogeneous substoichiometric catalyst. In a short time period (30 min), at 100 °C, the conversion rate was 73%, with a selectivity of 62% of the desired acylated product; the reaction was run continuously for 6 h, showing excellent stability and selectivity. Moreover, the unreacted starting material, 1,3-benzodioxole, can be easily separated by distillation and recycled.
African Under-Utilized Medicinal Leafy Vegetables Studied by Microtiter Plate Assays and High-Performance Thin-Layer Chromatography–Planar Assays
Authors: Oresanya Ibukun O. , Orhan Ilkay Erdogan , Heil Julia , Morlock Gertrud E.
Published: February 2024

Biological activities of six under-utilized medicinal leafy vegetable plants indigenous to Africa, i.e., Basella alba, Crassocephalum rubens, Gnetum africanum, Launaea taraxacifolia, Solanecio biafrae, and Solanum macrocarpon, were investigated via two independent techniques. The total phenolic content (TPC) was determined, and six microtiter plate assays were applied after extraction and fractionation. Three were antioxidant in vitro assays, i.e., ferric reducing antioxidant power (FRAP), cupric reduction antioxidant capacity (CUPRAC), and 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging, and the others were enzyme (acetylcholinesterase, butyrylcholinesterase, and tyrosinase) inhibition assays. The highest TPC and antioxidant activity from all the methods were obtained from polar and medium polar fractions of C. rubens, S. biafrae, and S. macrocarpon. The highest acetyl- and butyrylcholinesterase inhibition was exhibited by polar fractions of S. biafrae, C. rubens, and L. taraxacifolia, the latter comparable to galantamine. The highest tyrosinase inhibition was observed in the n-butanol fraction of C. rubens and ethyl acetate fraction of S. biafrae. In vitro assay results of the different extracts and fractions were mostly in agreement with the bioactivity profiling via high-performance thin-layer chromatography–multi-imaging–effect-directed analysis, exploiting nine different planar assays. Several separated compounds of the plant extracts showed antioxidant, α-glucosidase, α-amylase, acetyl- and butyrylcholinesterase-inhibiting, Gram-positive/-negative antimicrobial, cytotoxic, and genotoxic activities. A prominent apolar bioactive compound zone was tentatively assigned to fatty acids, in particular linolenic acid, via electrospray ionization high-resolution mass spectrometry. The detected antioxidant, antimicrobial, antidiabetic, anticholinesterase, cytotoxic, and genotoxic potentials of these vegetable plants, in particular C. rubens, S. biafrae, and S. macrocarpon, may validate some of their ethnomedicinal uses.
Hyaluronan: Sources, Structure, Features and Applications
Authors: Valachová Katarína , Hassan Mohamed E. , Šoltés Ladislav
Published: February 2024

Hyaluronan (HA) is a non-sulfated glycosaminoglycan that is present in a variety of body tissues and organs. Hyaluronan has a wide range of biological activities that are frequently influenced by molar mass; however, they also depend greatly on the source, purity, and kind of impurities in hyaluronan. High-molar-mass HA has anti-inflammatory, immunosuppressive, and antiangiogenic properties, while low-molar-mass HA has opposite properties. A number of chemical modifications have been performed to enhance the stability of HA and its applications in medical practice. Hyaluronan is widely applied in medicine, such as viscosupplementation, ophthalmology, otolaryngology, wound healing, cosmetics, and drug delivery. In this review, we summarized several medical applications of polymers based on the hyaluronan backbone.
Physicochemical Properties of Dried and Powdered Pear Pomace
Authors: Krajewska Anna , Dziki Dariusz , Yilmaz Mustafa Abdullah , Özdemir Fethi Ahmet
Published: February 2024

Pear pomace, a byproduct of juice production, represents a valuable reservoir of bioactive compounds with potential health benefits for humans. This study aimed to evaluate the influence of drying method and temperature on pear pomace, specifically focusing on the drying kinetics, grinding characteristics, color, phenolic profile (LC-MS/MS), and antioxidant activities of the powder. Drying using the contact method at 40 °C with microwave assistance demonstrated the shortest duration, whereas freeze-drying was briefer compared to contact-drying without microwave assistance. Freeze-drying resulted in brighter and more easily comminuted pomace. Lyophilized samples also exhibited higher total phenolic compound levels compared to contact-dried ones, correlating with enhanced antioxidant activity. Twenty-one phenolic compounds were identified, with dominant acids being quinic, chlorogenic, and protocatechuic. Flavonoids, primarily isoquercitrin, and rutin, were also presented. Pear pomace dried via contact at 60 °C contained more quinic and protocatechuic acids, while freeze-dried pomace at the same temperature exhibited higher levels of chlorogenic acid, epicatechin, and catechin. The content of certain phenolic components, such as gallic acid and epicatechin, also varied depending on the applied drying temperature.
A Portable Electrochemical Dopamine Detector Using a Fish Scale-Derived Graphitized Carbon-Modified Screen-Printed Carbon Electrode
Authors: Yang Feng , Han Xiao , Ai Yijing , Shao Bo , Ding Weipin , Tang Kai , Sun Wei
Published: February 2024

In this paper, a highly conductive alkali-activated graphitized carbon (a-GC) was prepared using tilapia fish scales as precursors through enzymolysis, activation and pyrolytic carbonization methods. The prepared a-GC was modified on the surface of a screen-printed carbon electrode to construct a flexible portable electrochemical sensing platform, which was applied to the differential pulse voltametric detection of dopamine (DA) using a U-disk electrochemical workstation combined with a smart phone and Bluetooth. The prepared a-GC possesses good electrical conductivity, a large specific surface area and abundant active sites, which are beneficial for the electrooxidation of DA molecules and result in excellent sensitivity and high selectivity for DA analysis. Under the optimal conditions, the oxidation peak current of DA increased gradually, with its concentrations in the range from 1.0 μmol/L to 1000.0 μmol/L, with the detection limit as low as 0.25 μmol/L (3S/N). The proposed sensor was further applied to the determination of DA in human sweat samples, with satisfactory results, which provided an opportunity for developing noninvasive early diagnosis and nursing equipment.
The Effect and Mechanism of Oleanolic Acid in the Treatment of Metabolic Syndrome and Related Cardiovascular Diseases
Authors: Luo Quanye , Wei Yu , Lv Xuzhen , Chen Wen , Yang Dongmei , Tuo Qinhui
Published: February 2024

Metabolic syndromes (MetS) and related cardiovascular diseases (CVDs) pose a serious threat to human health. MetS are metabolic disorders characterized by obesity, dyslipidemia, and hypertension, which increase the risk of CVDs’ initiation and development. Although there are many availabile drugs for treating MetS and related CVDs, some side effects also occur. Considering the low-level side effects, many natural products have been tried to treat MetS and CVDs. A five-cyclic triterpenoid natural product, oleanolic acid (OA), has been reported to have many pharmacologic actions such as anti-hypertension, anti-hyperlipidemia, and liver protection. OA has specific advantages in the treatment of MetS and CVDs. OA achieves therapeutic effects through a variety of pathways, attracting great interest and playing a vital role in the treatment of MetS and CVDs. Consequently, in this article, we aim to review the pharmacological actions and potential mechanisms of OA in treating MetS and related CVDs.
Special Issue on the State-of-the-Art Optical Properties and Applications of Metallic Nanostructures in Asia
Authors: Chiang Hai-Pang
Published: February 2024

With developments in nanofabrication technology, the optical properties and applications of metallic nanostructures have attracted increased research interest in recent years [...]
pH-Responsive Graphene Oxide-Based 2D/3D Composite for Enhancing Anti-Corrosion Properties of Epoxy Coating
Authors: Wang Jian , Cao Yangyang , Wan Jieru , Zhang Meng , Li Yunqiang , Wang Yanli , Song Dalei , Zhang Tao , Wang Jun
Published: February 2024

The functionalized graphene oxide (GO)-based composites as fillers added into organic coatings are desired for realizing the longstanding corrosion protection of carbon steel. Here, the pH-responsive two-dimensional/three-dimensional (2D/3D) GO-based composite (ZIF–90–AAP/GO) was developed by environmentally friendly corrosion inhibitor 4-aminoantipyrine (AAP) anchored on the in situ growth of zeolite imidazolate framework–90 (ZIF–90) on the GO surface (ZIF–90/GO) through the Schiff base reaction. The active filler (ZIF–90–AAP/GO) was incorporated into an epoxy coating (EP) to obtain a high-performance self-healing coating on the surface of carbon steel. ZIF–90–AAP can greatly improve dispersion and compatibility of GO in EP. The low-frequency impedance modulus of ZIF–90–AAP/GO–EP can still reach up to 1.35 × 1010 Ω⋅cm2 after 40 days, which is about three orders of magnitude higher than that of the EP containing GO (GO–EP) relying on its passive and active corrosion protection. Meanwhile, ZIF–90–AAP/GO–EP exhibits excellent self-healing performance. The self-healing rate of ZIF–90–AAP/GO changes from negative to positive after 24 h, which results from the effective corrosion inhibition activity of ZIF–90–AAP for carbon steel based on the pH-triggered controlled release of AAP. The developed pH-responsive 2D/3D GO-based composite coating is very attractive for the corrosion protection of carbon steel.
Scoping Review of Available Culinary Nutrition Interventions for People with Neurological Conditions
Authors: Chun Chian Thong (Nicole) , MacDonald-Wicks Lesley , English Coralie , Lannin Natasha A. , Patterson Amanda
Published: February 2024

People with neurological conditions may face barriers to meal preparation. Culinary nutrition interventions aim to facilitate the building of knowledge and skills for meal preparation. This scoping review aims to map the available evidence for culinary nutrition interventions for people with neurological conditions and evaluate the quality of these interventions based on program design, delivery and evaluation. After a systematic search of online databases (MEDLINE, CINAHL, Embase, Scopus and Proquest) and reference lists, a total of ten publications describing nine interventions were included. Most interventions were designed for people with stroke and/or Transient Ischemic Attack (n = 3) and Multiple Sclerosis (n = 3); others were for traumatic brain injury (n = 1), mild dementia (n = 1) and Parkinson’s Disease (n = 1). Overall, the included culinary nutrition interventions had good program delivery (inclusion of motivational experiences, delivered by appropriate health providers) but needed improvements in program design (lack of consumer engagement and neurological symptom accommodations) and evaluation (lack of complete process, outcome and impact evaluations). In conclusion, the evidence base for culinary nutrition interventions for people with neurological conditions remains sparse. To bridge the gap between theory and practice, it is important to consider the following aspects in culinary nutrition intervention planning/improvement: (I) the involvement of consumers; (II) the accommodation/tailoring for post-condition effects; and (III) the coverage of all disease-specific culinary nutrition aspects.