bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH PENGARUH KOMPLEKSITAS PERUSAHAAN, PROFITABILITAS, KEPEMILIKAN PUBLIK, DAN PROBABILITAS KEBANGKRUTAN TERHADAP AUDIT DELAY PADA PERUSAHAAN PERDAGANGAN, JASA, DAN INVESTASI YANG TERDAFTAR DI BEI TAHUN 2018 – 2022
Authors: Fahmi Fahmi Abdul Aziz , Sudarmadji Herry Sutrisno
Published: October 2023

Penelitian ini bertujuan menganalisa bagaimana faktor-faktor seperti, profitabilitas, kepemilikan publik, kompleksitas perusahaan dan probabilitas kebangkrutan berkontribusi pada penundaan audit. Perusahaan dalam Bursa Efek Indonesia (BEI) sebagai perdagangan, jasa serta investasi antara tahun 2018 dan 2022 menjadi sampel untuk analisis ini. Data selama empat tahun dari 41 bisnis infrastruktur, utilitas, dan transportasi yang terdaftar di Bursa Efek Indonesia menghasilkan 205 observasi. Purposive sampling digunakan sebagai metode pengumpulan data. Analisis regresi berganda dilakukan untuk menginterpretasikan hasil penelitian ini. Dalam penelitian ini ditemukan penundaan audit dipengaruhi oleh faktor-faktor kompleksitas perusahaan, profitabilitas, kompleksitas perusahaan, dan kemungkinan kebangkrutan. Kepemilikan oleh sektor publik tidak ada hubungannya dengan penundaan audit.
ANTESEDEN DAN KONSEKUEN DARI KINERJA RANTAI PASOK TERPADU PADA LAYANAN RUMAH SAKIT SWASTA
Authors: Pratiwi Putri Mega , Wahyuningsih Santosa
Published: October 2023

Tujuan penelitian ini adalah untuk menganalisis pengaruh hubungan karyawan, pertukaran pengetahuan, fleksibilitas rantai pasok, orientasi organisasi, kinerja rantai pasok terpadu terhadap fokus pasien/pelanggan. Data diperoleh dengan menyebarkan kuesioner secara online kepada karyawan medis dari rumah sakit swasta Mitra Keluarga Group. Sampel yang digunakan pada penelitian ini sebanyak 250 responden. Metode analisis data yang digunakan pada penelitian ini untuk menganalisis pengaruh antar variabel-variabel yang dimiliki menggunakan metode Structural Equation Model (SEM) dengan bantuan software AMOS 24. Hasil penelitian ini menyimpulkan hubungan karyawan, pertukaran pengetahuan, fleksibilitas rantai pasok, orientasi organisasi berpengaruh positif terhadap kinerja rantai pasok terpadu, kinerja rantai pasok terpadu berpengaruh positif terhadap fokus pasien/pelanggan.
PENGARUH STRUKTUR AKTIVA, PERTUMBUHAN PENJUALAN, RISIKO BISNIS, DAN TAX AVOIDANCE TERHADAP STRUKTUR MODAL DAN NILAI PERUSAHAAN STUDI PADA PERUSAHAAN SEKTOR PROPERTI DAN REAL ESTATE YANG TERDAFTAR DI BEI PERIODE 2017 - 2021
Authors: Sinaga Maria Uliarta , Aqamal Haq
Published: October 2023

Penelitian ini menganalisa pengaruh struktur aktiva, pertumbuhan penjualan, risiko bisnis, dan tax avoidance terhadap struktur modal dan nilai perusahaan studi perusahaan sektor property dan real estate yang terdaftar di BEI periode 2017 - 2021. Sampel penelitian ini ialah 16 perusahaan sektor property dan real estate. Perkembangan ekonomi sektor properti dan real estate di Indonesia tumbuh positif meskipun dilanda pandemi Covid 2019. Pada masa pandemi Covid 2019, perusahaan sektor properti dan real estate menurunkan harga properti tetapi hal tersebut membawa dampak positif terhadap sektor ini. Jenis penelitian yang digunakan ialah penelitian kuantitatif dengan teknik purposive sampling. Penelitian ini menggunakan data sekunder yang diperoleh dari laporan keuangan. Penelitian ini menggunakan analisis regresi linier berganda dan jenis penelitiannya ialah penelitian korelasional. Hasil penelitian menunjukkan struktur aktiva mempengaruhi secara negatif terhadap struktur modal. Pertumbuhan penjualan dan risiko bisnis tidak mempengaruhi struktur modal. Tax Avoidance mempengaruhi secara positif terhadap struktur modal. Struktur aktiva, risiko bisnis, dan tax avoidance tidak mempengaruhi nilai perusahaan. Pertumbuhan Penjualan mempengaruhi secara positif terhadap nilai perusahaan. Struktur modal mempengaruhi secara positif terhadap nilai perusahaan.
PENGARUH GREEN ACCOUNTING, CORPORATE SOCIAL RESPONSIBILITY DAN FINANCIAL DISTRESS TERHADAP NILAI PERUSAHAAN PADA PERUSAHAAN MANUFAKTUR SEKTOR CONSUMER GOODS YANG TERDAFTAR DI BEI 2019-2021
Authors: Selvia Selvia Monica , Virna Sulfitri
Published: October 2023

Tujuan penelitian  ini adalah untuk menganalisis pengaruh Green Accounting terhadap Nilai perusahaan, Menganalisis  pengaruh Corporate Sosial Responsibility terhadap nilai perusahaan, Menganalisis dampak Financial Distress terhadap nilai perusahaan. Pemilihan data melalui laporan financial dan annual report yang terdaftar di BEI 2019-2021. Unit analysis  dalam penelitian ini company manufaktur dari layanan data BEI. Data yang akan dipakai dalam penelitian ini ialah data sekunder dengan metode Purposive Sampling. Hasil yang diharapkan dalam penelitian ini disimpulkan bahwa Green accounting berdampak signifikan dan positif, Corporate Social Responsibilty berdampak signifikan dan positif, Financial Distress berdampak signifikan dan negatif terhadap nilai company manufaktur periode 2019–2021.
PENGARUH KINERJA KEBERLANJUTAN TERHADAP EFISIENSI INVESTASI PADA PERUSAHAAN YANG TERDAFTAR DALAM INDEKS SRI KEHATI
Authors: Prastiwi Raden Rara Adila , Idrianita Anis
Published: October 2023

Penelitian ini bertujuan untuk mengetahui secara empiris pengaruh Integrasi Keberlanjutan, Intensi Keberlanjutan, Implementasi Keberlanjutan dan Keseluruhan Kesadaran Keberlanjutan terhadap Efisiensi Investasi. Penelitian ini menggunakan metodologi kuantitatif dengan memanfaatkan data sekunder. Sampel penelitian ini dipilih melalui seleksi purposif, khususnya menyasar organisasi-organisasi yang termasuk dalam Indeks SRI KEHATI dan pencatatan BEI dari tahun 2017 hingga 2021. Penelitian ini menggunakan perangkat lunak Eviews untuk menilai hipotesis melalui penerapan regresi linier beragam metode. Hasil penelitian menunjukkan bahwasanya Integrasi Keberlanjutan, Intensi Keberlanjutan, Implementasi Keberlanjutan dan Keseluruhan Kesadaran Keberlanjutan berpengaruh positif terhadap Efisiensi Investasi.
PENGARUH KOMITE AUDIT, DEWAN KOMISARIS INDEPENDEN, DEWAN DIREKSI DAN KEPEMILIKAN INSTITUSIONAL TERHADAP KINERJA KEUANGAN PERUSAHAAN
Authors: Pramudityo Wifa Arum , Sofie
Published: October 2023

Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh komite audit, dewan komisaris independent, dewan direksi dan kepemilikan institusional dengan populasi perusahaan perbankan terdaftar dalam Bursa Efek Indonesia periode 2017 – 2021 dengan menggunakan metode purposive sampling dengan sampel sebanyak 193. Teknik analisis data yang digunakan adalah analisis regresi linear berganda. Hasil analisis menunjukan bahwa secara parsial  (1) Dewan Direksi berpengaruh positif terhadap Kinerja Keuangan. (2) Komite Audit tidak berpengaruh terhadap Kinerja Keuangan. (3) Dewan Komisaris Independen tidak berpengaruh terhadap Kinerja Keuangan Perusahaan. (4) Kepemilikin instusional  tidak berpengaruh terhadap Kinerja Keuangan.
PENGARUH GREEN ACCOUNTING DAN KINERJA LINGKUNGAN TERHADAP NILAI PERUSAHAAN DENGAN PROFITABILITAS SEBAGAI VARIABEL MODERASI
Authors: Goldie Kelly Sandra , Deliza Henny
Published: October 2023

Aktivitas perekonomian yang kian normal setelah pandemic covid-19 menjadi salah satu pemicu isu kesehatan lingkungan. Adanya Green Topic yang muncul hari-hari ini meningkatkan kesadaran masyarakat tentang pentingnya kesehatan lingkungan. Perusahaan yang memiliki aspek kesehatan lingkungan yang yang baik akan memiliki nilai perusahaan yang baik di mata masyarakat dan investor. Penelitian ini dilakukan untuk menguji dan menganalisis pengaruh Akuntansi Hijau dan Kinerja Lingkungan perusahaan terhadap Nilai Perusahaan yang dimoderasi profitabilitas. Populasi pada penelitian ini adalah seluruh perusahaan sub sektor Food& Beverage yang terdaftar di Bursa Efek Indonesia yaitu sebanyak 33 perusahaan. Sampel penelitian ini ditentukan dengan teknik purposive sampling sehingga diperoleh sejumlah 51 sampel. Analisis data dilakukan dengan Moderate Regression Analysis.  Hasil penelitian menunjukkan bahwa green accounting  dan kinerja lingkungan tidak berpengaruh secara langsung pada nilai perusahaan, profitabiltias berpengaruh terhadap nilai perusahaan, sedangkan dengan adanya variable intervening profitabilitas  membuktikan green accounting dan kinerja lingkungan berpengaruh pada nilai perusahaan.
PENGARUH KARAKTERISTIK CEO TERHADAP PROFITABILITAS PERUSAHAAN PADA PERUSAHAAN TEKNOLOGI YANG TERDAFTAR DI BEI TAHUN 2018-2022
Authors: Wijaya Marcja Angeline , Darmawati Deni
Published: October 2023

Penelitian ini bertujuan untuk menganalisis pengaruh karakteristik CEO terhadap profitabilitas perusahaan. Variabel terikat dalam penelitian ini adalah profitabilitas yang diproksikan dengan ROA. Variabel bebas dalam penelitian ini adalah karakteristik CEO yang meliputi umur, jenis kelamin, masa jabatan, pendidikan, dualitas, kewarganegaraan, ownership, keahlian (pengalaman), dan pergantian CEO. Penelitian ini merupakan penelitian kuantitatif dengan metode kausal komparatif. Pengambilan sampel dalam penelitian ini menggunakan purposive sampling method dan diperoleh total sampel sebanyak 85. Teknik analisis yang digunakan dalam penelitian ini adalah analisis regresi linear berganda. Hasil penelitian menunjukkan bahwa ownership CEO dan dualitas CEO berpengaruh terhadap profitabilitas perusahaan. Umur, jenis kelamin, masa jabatan, pendidikan, kewarganegaraan, keahlian, dan pergantian CEO tidak berpengaruh terhadap profitabilitas perusahaan.
PENGARUH KEPEMILIKAN INSTITUSIONAL DAN KEBIJAKAN DIVIDEN TERHADAP KINERJA PERUSAHAAN DENGAN UMUR PERUSAHAAN SEBAGAI VARIABEL KONTROL PADA PERUSAHAAN SEKTOR MANUFAKTUR YANG TERDAFTAR DI BEI 2019-2021
Authors: Arnitia Rahmatika  , Idrianita Anis
Published: October 2023

This study examines the impact of institutional ownership and dividend policy on the financial outcomes of manufacturing businesses trading on the Indonesia Stock Exchange (BEI) from 2019 to 2021, with the impact of company age serving as a control variable. To determine an organization's Return On Assets (ROA), net income is divided by its total assets. The age of a company is calculated by subtracting the current year from the year it was founded; the Institutional Ownership Ratio compares the percentage of shares owned by institutions to the total number of shares outstanding; and the Dividend Payout Ratio (DPR) evaluates dividends paid to shareholders in relation to earnings per share. The 183 companies included in this study were chosen using a stratified random selection technique. This study's results suggest that (1) institutional ownership significantly affects firm performance in a positive way. (2) A dividend plan is excellent for a company's bottom line.
PENGARUH MODAL MANUSIA HIJAU, MODAL STRUKTURAL HIJAU, MODAL RELASIONAL HIJAU TERHADAP KINERJA PERUSAHAAN DENGAN KEUNGGULAN KOMPETITIF HIJAU SEBAGAI VARIABEL MODERASI
Authors: Hunafah Diftya Rachmitha , Rachmawati Sistya
Published: October 2023

Tujuan dari penelitian ini untuk mengetahui pengaruh modal structural hijau, modal manusia hijau, dan modal relasional hijau terhadap kinerja perusahaan. Penggunaan variabel moderasi  yaitu keunggulan kompetitf hijau. Laporan tahunan yang berlanjut didapatkan dari riset ini, yaitu instansi sektor bukan keuangan yang ada pada Bursa Efek Indonesia (BEI), merupakan data sekunder pada riset ini. Sampel pada target sampling menggunakan 420 instansi di tahun 2021. Penggunaan analisis regresi linier ganda yaitu SPPS v 22.0 dipilih penelitii.  Hasil menunjukkan bahwa modal manusia hijau dan modal relasional hijau tidak berpengaruh terhadap kinerja perusahaan. Yang berpengaruh dalam kinerja perusahaan  yaitu modal struktural hijau. Variabel keunggulan kompetitf hijau memperlemah modal manusia hijau, dan modal relasional hijau terkait dengan kinerja perusahaan, sedangkan keunggulan kompetitf hijau dapat memperkuat modal struktural hijau terkait dengan kinerja perusahaan.
PENGARUH ELEMEN FRAUD PENTAGON TERHADAP KECURANGAN LAPORAN KEUANGAN PADA PERUSAHAAN SEKTOR CONSUMER NON CYCLICALS YANG TERDAFTAR DI BURSA EFEK INDONESIA PERIODE 2018-2021
Authors: Sahas Ainina Nur Azizah , Deliza Henny
Published: October 2023

Pengujian ini bertujuan untuk menganalisis dampak komponen pentagon terhadap Fraudulent Financial Statement. Tekanan sebagai proksi tekanan eksternal, peluang sebagai proksi pengawasan yang tidak efektif, rasionalisasi sebagai proksi pergantian auditor, kapabilitas sebagai proksi pergantian direktur, arogansi sebagai proksi seringnya jumlah foto CEO, dan kepemilikan oleh manajemen adalah enam hal variabel didalam riset ini. Pemeriksaan ini menggunakan strategi kuantitatif dan berasal dari informasi opsional. Contoh yang digunakan adalah 132 perusahaan di Bursa Efek Indonesia pada sektor consumer non cyclical tahun 2018-2021. Strategi yang digunakan adalah pengujian purposive. Hasil yang diperoleh dalam penelitian External Presure, Ineffective Monitoring, dan Change of Director berpengaruh positif terhadap kecurangan laporan keuangan. Change in Auditor dan Frequent Number of CEO’s Picture tidak berpengaruh signifikan terhadap kecurangan yang didapati pada laporan keuangan, serta Ownership by Management berpengaruh negative terhadap fraudulent financial statement.
Effect of Low-Level Laser on The Pain PerceptionFollowing Dental Extraction
Authors: Sh Rajab Muthenna , M Ali Abdulrahman , Jamel Alaa
Published: October 2023

The goal of this study was to determine the effectiveness of a single dose of low-level laser therapy (LLLT) on the pain of patients after tooth extraction. Thirty patients in total were divided into two treatment groups. Each group consists of fifteen patients. Group A received a single dose of LLLT 20 minutes after tooth extraction with (0.3 W, 30 sec, 9 J/cm2) diode laser. The irradiation was extra-orally 1 cm away from the site of interest. Group B is the control group. The patients' level of pain was assessed. Visual analog scale (VAS) was utilized to quantify pain intensity in the 2nd and 7th days after extraction. Results indicated that (Group A) had significantly decreased VAS values than (Group B) on postoperative day 7. The current study suggested that there is a significant effect of single dose (LLLT) on lowering pain following tooth extraction.
Öğretmenler için İçsel Motivasyon Faktörleri: Motivasyon 3.0 Ölçeğinin Geliştirilmesi, Geçerlilik ve Güvenilirlik Çalışması
Authors: YASTIOĞLU Seher
Published: October 2023

Bu çalışmanın amacı, eğitim örgütlerinde öğretmenlerin içsel motivasyon deneyimleri altında yatan faktörleri ortaya koymak adına; Daniel Pink tarafından Harry Harlow ve Edward Deci’nin çalışmalarından esinlenerek ileri sürülen Motivasyon 3.0 diğer bir ifade ile içsel motivasyon yaklaşımı temelinde ‘Öğretmenler için Motivasyon 3.0 Ölçeği’ni geliştirmek, geçerliliğini ve güvenilirliğini test etmektir. Bu amaçla, ölçek geliştirme sürecinde sıralı üç çalışma yürütülmüştür. Birinci çalışmada alan yazından faydalanılarak ve öğretmenlerle gerçekleştirilen yapılandırılmış mülakatlardan elde edilen nitel bulgular kullanılarak madde havuzu oluşturulmuştur. Kapsam geçerliliği için alan uzmanlarından ve ölçeğin hedef kitlesi olan öğretmenlerden görüş alınmış ve taslak ölçme aracı oluşturulmuştur. Nicel araştırma yöntemi kullanılarak yürütülen Çalışma 2 ve Çalışma 3’te ilköğretim ve ortaöğretim okullarında çalışan toplam 779 öğretmenden elde edilen veriler üzerinden yapılan keşfedici, doğrulayıcı faktör analizleri, güvenilirlik ve ilişki analizleri ile ölçeğin yapı geçerliliği, güvenilirliği ve eş zamanlı geçerliliğine dair kanıtlar elde edilmiştir. Nihai durumda anlamlı amaç, uzmanlık (ustalık) ve özerlik olmak üzere 3 faktör ve 29 maddeden oluşan, öğretmenlerin içsel motivasyon düzeylerinin ve faktörlerinin belirlenmesinde kullanılabilecek ölçme aracı alan yazına kazandırılmıştır. Bununla birlikte, öğretmenlerin hem duygusal iyi oluşunu hem de öğrenciye yönelik ekstra rol davranışını daha fazla arttıran boyutun uzmanlık (ustalık) olduğu tespit edilmiştir.
USING NEURAL NETWORKS AND MOLECULAR DYNAMICS METHODS TO PREDICT BINDING AFFINITY IN PROTEIN-PROTEIN COMPLEXES
Authors:   Lomonosov Moscow State University, Bogdanova E.A. , Shaitan K.V. , Novoseletsky V.N.
Published: October 2023

Binding affinity is an important characteristic of protein-protein interactions, and its determination is important for the development of drugs and biotechnological preparations. This paper presents an algorithm based on convolutional neural networks that predicts the value of the dissociation constant in protein-protein complexes based on their spatial structure, as well as data processing and augmentation methods.
STRUCTURAL CHANGES OF BOVINE SERUM ALBUMIN IN IMPRINTING PROCESS
Authors:   Chernyshevsky Saratov State University, Soboleva P.M. , Burmistrova N.A.
Published: October 2023

In this work a molecular dynamics simulation of bovine serum albumin (BSA) was carried out at the first stage of imprinted proteins synthesis. Structural changes of BSA under acidic conditions was studied using dynamic light scattering and circular dichroism spectroscopy.
APPROBATION OF OBJECTIVE METHODS FOR ASSESSING CELLULAR CHANGES IN THE PAP TEST USING A GRAPHIC PROCESSOR AND A KNOWLEDGE BASE
Authors:   The Far Eastern Federal University, Vladivostok, Shcheglov B.O. ,   North-Eastern State University, Magadan, Shcheglova S.N. , Reva G.V.
Published: October 2023

This paper discusses the primary results of testing objective computerized methods for assessing cellular changes obtained during the Papanicolaou test at the FEFU Laboratory Diagnostic Center. The program analyzes the morphometric data on the image and enters them into the knowledge base, which, based on certain parameters, derives a hypothesis about the cell class according to the Bethesda system.
DIFFERENTIALLY EXPRESSED GENES PREDICTING RESPONSE TO TAMOXIFEN THERAPY IN BREAST CANCER PATIENTS
Authors:   Novosibirsk State University, . Shcherbakova S.A. , Karitskaya P.E. , Chesnokova A.S. , Karpets I.O. , Evgenov I.V. , Tseylikman D.V.
Published: October 2023

The study is aimed at finding genes mediating the response to tamoxifen therapy. Meta-analysis of the articles and the construction of gene networks revealed 7 genes that make a significant contribution to survival rates. For the purpose of validation, the approach of analysis of differential gene expression was chosen. The validation results revealed a high occurrence of the desired genes. The pattern of deviation of their expression from the reference values was combined with that indicated by other authors.
ECOLOGICAL FEATURES OF PREDATORY FUNGI-HYPHOMYCETES
Authors:   State Research Center of Virology and Biotechnology VECTOR, Koltsovo, Belaya T.D.
Published: October 2023

Predatory fungi are unique microorganisms that inhabit almost the entire planet Earth and are natural regulators of the nematode population in the soil. But despite their ubiquity, they have not been studied fully enough. However, the data obtained as a result of the conducted studies indicate the prospect of using predatory fungi as a control against pathogenic nematodes in the field of crop production and veterinary medicine.
Relação da classificação socioeconômica, uso de álcool e dependência de nicotina em universitários
Authors: Clark Lauren Matozinhos , Silva Lays Figueiredo Inácio da Silva , Peres Marcelo Vieira , Carvalho Marco Túlio Menezes , Silva Vanessa Luzia Queiroz , Borges Amanda Aparecida , Pereira Vanessa Oliveira Silva , Oliveira Iácara Santos Barbosa , Nascimento Juliana da Silva Garcia , Alves Mateus Goulart
Published: October 2023

Objetivo: Analisar a relação da classificação socioeconômica com o uso de álcool e dependência de nicotina em um grupo de universitários. Métodos: Estudo descritivo, transversal, de abordagem quantitativa, envolvendo universitários de uma cidade do sudoeste de Minas Gerais. A coleta de dados foi realizada através de um formulário do Google Forms entre agosto e setembro de 2021 utilizando um Questionário de Caracterização Sociodemográfica, Teste de Fagerström e Teste Alcohol Use Disorders Identification Test-Consumption. Utilizado o teste exato de Fisher e adotado o nível de significância estatística de 5% para as análises estatísticas. Resultados: Participaram 539 universitários e observou-se que o consumo de bebida alcoólica foi 68%, já o uso de nicotina em 7,9%. A classe econômica dominante foi a B2 (37%). Observou-se uso de álcool maior que 60% em todas as classes sociais e uso nicotina prevaleceu nas classes B e C. Conclusão: Ambas as substâncias não apresentaram resultados significativos ao serem relacionadas com os fatores socioeconômicos. Porém, mediante ao número de usuários de álcool e tabaco e os impactos de tais substâncias, destaca-se a necessidade de implementar medidas terapêuticas, educativas e preventivas entre universitários.
Evaluation of Few Immunological Parameters in Patients with Chronic Renal Failure in Najaf
Authors: E. Naser Buthaina Abd , Mahdi Zainab S
Published: October 2023

Kidney failure is a chronic disease currently spreading worldwide, and one of its most important complications. Many indicators can be used to detect kidney disease early, which, if not treated, will eventually lead to failure. Kidney disease often leads to death. The study aimed to find a relationship between chronic renal failure and some immunological parameters and its relationship to the mechanism of dialysis, if it was hemorrhagic or peritoneal This study was conducted at the Kidney Center in Al-Sadr Teaching Hospital, Al-Najaf, and lasted from September 2022 to May 2023, including 57 males with chronic renal failure and 33 males. Listening male subjects who were considered as a control group. It was divided into age groups from 20 to 70, the duration of infection from 1 to 4 years, 5 to 7 and 8 to 15 years, and the body mass index included normal, excess, and obesity for patients with hemodialysis, peritoneal dialysis, and patients who did not reach the stage hemodialysis. The study concluded significant differences in the immunological indicators MCP-1 NTN-1, IL-1, α-TNF in the renal failure serum compared with healthy subjects. There was a positive relationship in the MCP-1, NTNT-1,IL-1, α TNF level. The results showed that there are significant differences p < 0.05 in age groups and body mass index in patients with renal failure compared with healthy subjects. There are no significant differences p > 0.05 with the duration of infection in patients with chronic renal failure compared with healthy controls. The presence of significant differences predicted kidney failure, p < 0.05, in the MCP-1 immunological indicators NTN-1, IL-1, α-TNF –TNF, The approved ROC table in patients with renal failure showed that the highest area of the biomarker NTN-1 and the lowest area is the biomarker α- TNF and immunological indicators are considered as predictors of early diagnosis of chronic renal failure.
Synthesis, Characterisation, Molecular Docking Studies and Biological Evaluation of Novel Benzothiazole Derivatives as EGFR Inhibitors for Anti-breast Cancer Agents
Authors: Priya M Gnana R. , Devhare Lalchand D. , Dharmamoorthy G. , Khairnar Mahendra V. , Prasidha R.
Published: October 2023

Novel (2-anilino-N-(4,6-dimethyl-1,3-Benzosulfonazol-2-yl) ethanamide derivatives were synthesized and characterized by spectroscopy methods. All the compounds assessed for in-vitro antimicrobial activities on three strains are S. aureus, S. epidermis and E. coli by using disc plate method (25 μg/mL). Compounds 5a-5j showed good to excellent antimicrobial activity for three different strains compared to standard ciprofloxacin. Further screened by in-vitro cytotoxic activity against MCF-7 cell lines. Some compounds were 5i, 5c, 5b,5d and 5i showed high cytotoxic activities of IC50 values 73, 53,37,32 and 24 μg/mL, reference drug as Gefitinib against MCF-7 cell lines and MCF-12A. Further carried out docking studies using Schrodinger software to analyze the orientations, interactions and binding modes of these derivatives at the adenine -5-triphosphate binding site of EGFR (PDB ID: 2ITY), which indicated that the ligands show good interactions with active site residues in this structural benzothiazole class, and are considered lead compounds for further development as anti-breast cancer drugs
Preterm Labor with Side Effects: Compare the Effectiveness of Magnesium Sulfate (MgSO4) with Isoxsuprine
Authors: Patil Yamini , Havle Padmaja A , Raje Shivaji V , Shinde Gauri
Published: October 2023

Background: In India, 25% of pregnancies develop preterm labor (PTL), resulting in 10 to 69% cases of preterm birth. Medical intervention to stop labor, reduce infection rate, and avoid infant respiratory distress has been the subject of studies for a long time. PTL patients usually get tocolytics, corticosteroids, antibiotics, and other clinically symptomatic and supportive therapy to accomplish this goal. Studies further showed that these tocolytic drugs lower intracellular calcium bioavailability via biochemical pathways, hindering the interaction of actin-myosin. Due to the poor success rate of labor arrest, researchers concluded from their studies that widespread adoption of medical management for PTL has been hampered. The high rate of major side effects of tocolytic drugs, particularly beta-mimetic ones, exacerbated this. We know of no clinical evidence on PTL management in India. Objective: The effectiveness and maternal side effects of MgSO4 and isoxsuprine in PTL arrest. Methods: In our study, we included a total of 82 pregnant women who had PTL discomfort and were admitted to the labor department. Both groups were randomly assigned patients. “Group 1 patients received isoxsuprine hydrochloride, whereas group 2 patients received MgSO4”. After that, a comprehensive clinical examination included vital signs, general, systemic, external genitalia, and PV (per vaginal) results. Investigations include CBC, BT, CT, urine full examination, ABO, RH group, serum electrolytes, RBS, vaginal swab, and Renal function test (RFT). Result: Significant difference (p <0.05) indicated that MgSO4 was more effective. Conclusion: MgSO4 can be used as a tocolytic agent in PTL as it shows better tolerance capacity when compared to isoxsuprine.
Evaluation of unruptured aneurysm scoring systems and ratios in subarachnoid hemorrhage patients with multiple intracranial aneurysms
Authors: Boutarbouch Mahjouba , Dokponou Yao Christian Hugues , Bankole Nourou Dine Adeniran , El Ouahabi Abdessamad , El Khamlichi Abdeslam
Published: October 2023

Background:

This study aims to appraise aneurysm scores and ratios’ ability to discriminate between ruptured aneurysms and unruptured intracranial aneurysms (UIAs) in subarachnoid hemorrhage (SAH) patients harboring multiple intracranial aneurysms (MICAs). We, then, investigate the most frequent risk factors associated with MICAs.

Methods:

We retrospectively applied unruptured intracranial aneurysm treatment score (UIATS) and population hypertension age size of aneurysm earlier SAH from another aneurysm site of aneurysm (PHASES) score, aspect, and dome-to-neck ratio to the 59 consecutive spontaneous SAH patients with MICAs admitted between January 2000 and December 2015 to the Department of Neurosurgery of the University Hospital Center “Hôpital des Spécialités” of Rabat (Morocco). Patients with at least two intracranial aneurysms (IAs) confirmed on angiography were included in the study.

Results:

Fifty-nine patients were harboring 128 IAs. The most frequent patient-level risk factors were arterial hypertension (AHT) 30.5 % (n = 18) and smoking status 22.0 % (n = 13). A PHASES score recommended treatment in 52 of 60 ruptured aneurysms and in six of 68 UIAs with a sensitivity of 31.67% and a specificity of 76.47%. UIATS recommended treatment in 26 of 62 ruptured aneurysms and in 35 of 55 UIAs with a sensitivity of 41.9% and a specificity of 63.6%. Aspect ratio recommended treatment in 60 of 60 ruptured aneurysms and in 63 of 68 UIAs with a sensitivity of 100% and a specificity of 88.24%. Dome-to-neck ratio recommended treatment in 45 of 60 ruptured aneurysms and in 48 of 68 UIAs with a sensitivity of 80% and a specificity of 63.24%. The aspect ratio (area under the curve [AUC] = 0.953) AUC > 0.8 has a higher discriminatory power between ruptured aneurysms and UIAs.

Conclusion:

AHT and smoking status were the most common risk factors for intracranial multiple aneurysms and the aspect ratio and PHASES score were the most powerful discrimination tools between ruptured aneurysms and the UIAs.
A novel technique of managing an irreducible posteriorly displaced type 2 odontoid fracture: A case report
Authors: Rathod Tushar , Prabhu Rudra Mangesh , Mohanty Shubhranshu Shekhar , Chandanwale Ajay
Published: October 2023

Background:

Type 2 odontoid fractures with posterior displacement are rare. Most acute cases reported in the literature are readily reduced with traction alone. Here, we reviewed the management of a chronic, posteriorly displaced odontoid fracture that was managed with a unique posterior reduction maneuver.

Case Description:

A 58-year-old male with a chronic type 2 retro-odontoid displaced fracture was managed with traction and an anterior force applied to the displaced odontoid fragment using rods attached to bilateral C1 lateral mass screws. Notably, this included a simultaneous cantilever maneuver using a lever placed between the C1 and C2 facet joints. Following reduction, an atlantoaxial fusion was performed. The postoperative course of the patient was uneventful and the bone union was achieved in 1 year.

Conclusion:

Closed reduction is rarely successful in chronic posteriorly displaced type 2 odontoid fractures. These cases require meticulous open reduction and fixation.
Intraoperative embolectomy of a left illiac artery thrombus during an anterior lumbar interbody fusion
Authors: Tigre Joseph Yunga , Puerto Aiko , Russo Jean-Paul , Kloehn Andrew J. , Abdullah Naaman , Burks S. Shelby , Levi Allan D.
Published: October 2023

Background:

Anterior lumbar interbody fusion (ALIF) offers direct midline access to the lumbar intervertebral discs utilizing an anterior retroperitoneal approach. Here, a 33-year-old female undergoing ALIF developed an acute intraoperative left iliac artery thrombus and underwent immediate successful embolectomy.

Case Description:

A 33-year-old female was undergoing routine L5-S1 ALIF when an acute intraoperative left iliac vein injury occurred, requiring immediate repair by a vascular surgeon. Her left foot pulse oximeter showed a decreased reading, and her Doppler ultrasound confirmed reduced flow in the distal external iliac artery due to a thrombus. She required an immediate left iliac artery embolectomy, and flow was immediately restored. Postoperatively, she recovered well, and 3 months postoperatively, she remained neurologically intact without any further complications.

Conclusion:

Using pulse oximeters in patients undergoing ALIF surgery can aid in facilitating the diagnosis and treatment of acute artery thrombi. When such vascular injuries arise, having immediate access to experienced vascular surgeons is critical to obtain expeditious treatment and optimize patient outcomes.
A Study on the Development Plan of Nationwide Special Judicial Police Suitable for the Dual Autonomous Police System
Authors:   The Korean Association of Criminal Psychology, Cho Je-Seong , Park Jun-Hwi
Published: October 2023

This study aims to explore empirical factors and make concrete recommendations on how to develop the Korean special judicial police force in a dualized autonomous police system. Through the literature review, it was found that there are the same issues for the implementation of the autonomous police system as for the special judicial police, such as job satisfaction, work avoidance, and identity confusion. Regression analyses were conducted to determine whether these factors affect the extent to which special law enforcement officers actually practice cooperation with the general police. The results showed that the higher the job satisfaction, the higher the perception of cooperation with the general police, while controlling for variables such as gender, age, and departmentalization. Considering that job satisfaction should be approached in a very comprehensive manner, the results are sufficiently indicative of how the special judicial police should develop in the future. Based on our findings, we made three main policy recommendations to improve job satisfaction and enhance cooperation with the police. First, the overall job satisfaction, second, the improvement of job satisfaction according to regional differences, and third, the establishment of self-governance in cooperation with the Autonomous Police Commission and the future-oriented operation of the Special Judicial Police. These are policy recommendations that can directly lead to job satisfaction and are expected to provide a new roadmap for the cooperation between the police and the special judicial police and the development of the special judicial police.
Enhancing recovery from plyometric circuit training: The synergistic impact of dynamic stretching, BCAA supplementation, and sports massage on DOMS
Authors: Fitrianto Ari Tri , Prayoga Hegen Dadang , Habibie Muhammad , Fitrian Zanzabil Adwa
Published: October 2023

Understanding the significance of efficient post-exercise recovery methods in alleviating muscle damage and addressing delayed onset muscle soreness (DOMS) among athletes following plyometric circuit training. The study aimed to determine the effect of dynamic stretching in water (active pool-based) and sports massage (SM) on muscle damage indices post-plyometric circuit training. A total of 30 participants were divided into three control groups and one experimental group, who were given two recovery protocols (APB + BCAA and sports massage) after the trial. Data were statistically analysed using a one-way ANOVA test with post-test measurements and a Bonferroni test (P < 0.05). It is concluded that statistically the APB + BCAA post-hoc test with SM did not show any significance. However, on average, APB + BCAA was preferable at reducing DOMS symptoms; measurements 3 and 4 in the intervention groups also showed a significant effect on the control group. The study findings underscore the valuable contribution of active recovery in water and the use of supplements in improving initial recovery outcomes after strenuous exercise or sports, aligning with the exercise recovery principle that highlights the inseparable relationship between nutrition and soft tissue modalities.
Correspondence on “Organo-Mediator Enabled Electrochemical Deuteration of Styrenes”
Authors: Kolb Simon , Werz Daniel B.
Published: October 2023

The recently reported electrochemical, organo mediator enabled deuteration of styrenes, a reaction referred to as “electrochemical deuterium atom transfer”, differs mechanistically from reported direct electrochemical hydrogenations/deuterations only by a mediated, homogeneous SET to the substrates. By comparing direct vs. mediated processes in general and for styrene reduction, we display that Qiu’s work does not change the concept of this chemistry. Experiments with mediators and the direct reduction of examples from the reported scope show that even electron-rich substrates can be reduced when our direct protocol, published six months before Qiu’s work, is applied.
Informatics and Computationally Assisted Discovery of Anti-Inflammatory Diterpenoids from Isodon rubescens
Authors: Liu Xiaoying , Bian Zhiwei , Li Hongyi , Hu Shian , Ferreira Daneel , Hamann Mark , Wang Shengpeng , Wang Xiaojuan
Published: October 2023

Diterpenoids occupy a valuable region of the natural products diversity space with wide ranges of bioactivities and complex structures, providing potential applications for the development of therapeutics. Five new abietane-type diterpenoids salvonitin B (1), salvonitin C (2), prionoid G (3), prionidipene F (4), viroxocin B (5), one new totarane-type diterpenoid plebedipene E (6) and one new sempervirane-type diterpenoid hispidanol C (7) were isolated from Isodon rubescens (I. rubescens). Their structures were established by spectroscopic analysis, electronic circular dichroism (ECD) calculations, and X-ray diffraction analysis. In the evaluation of bioactivities, compound 4 (10 μM) increased cell viability (0.872 ± 0.157) in lipopolysaccharide-induced RAW 264.7 cells.
Synthesis of Axially Chiral Biaryls via Pd(II)-Catalysed Direct C(sp2)-H Olefination and Arylation
Authors: Kumar Rohit , Parmar Diksha , - Sarthi , Chandra Devesh , - Sumit , Sharma Akhilesh K. , Sharma Upendra
Published: October 2023

Herein, two efficient reaction protocols for the construction of axially chiral biaryls via Pd-catalysed direct C-H functionalization of 1-arylisoquinoline N-oxides through kinetic resolution have been uncovered. The atroposelective C-H olefination of 1-arylisoquinoline N-oxides is achieved with alkenes such as acrylates, styrenes, phenylvinyl sulfone, acrylonitrile, and maleimides, while the arylation is successfully attained with iodoarenes. The commercially available, cost-effective, and bench-stable chiral mono-protected amino acid is successfully utilized as the chiral ligand to achieve atroposelective products via kinetic resolution. The high conformational stability of the axially chiral products in different solvents and at high temperatures, as observed from the experimental studies and DFT calculations, shows their excellent stability. A plausible mechanism has been proposed based on the preliminary mechanistic studies, which were further evidenced by DFT calculations.
Facile access to cationic methylstannylenes and silylenes stabilized by E‒Pt bonding and their methyl group transfer reactivity
Authors: Govindarajan Ramadoss , Fayzullin Robert R. , Deolka Shubham , Khaskin Eugene , Vasylevskyi Serhii , Vardhanapu Pavan K. , Pal Shrinwantu , Khusnutdinova Julia
Published: October 2023

We describe a family of cationic methylstannylene and chloro- and azidosilylene organoplatinum(II) complexes supported by a neutral, binucleating ligand. Methylstannylenes MeSn:+ are stabilized by coordination to PtII and are formed by facile Me group transfer from dimethyl or monomethyl PtII complexes, in the latter case triggered by concomitant B–H, Si–H, and H2 bond activation that involves hydride transfer from Sn to Pt. A cationic chlorosilylene complex was obtained by formal HCl elimination and Cl– removal from HSiCl3 under ambient conditions. The computational studies show that stabilization of cationic methylstannylenes and cationic silylenes is achieved through weak coordination to neutral N-donor ligand bind-ing pocket. The analysis of the electronic potentials, as well as the Laplacian of electron density, also reveals the differences in the character of Pt‒Si vs. Pt‒Sn bonding. We demonstrate the importance of a ligand-supported binuclear Pt/tetrel core and weak coordination to facilitate access to tetrylium-ylidene Pt complexes, and a transmetalation approach to the syn-thesis of MeSnII:+ derivatives.
Unveiling Transport Mechanisms of Cesium and Water in Operando Zero-Gap CO2 Electrolyzers
Authors: Óladóttir Joensen Bjørt , A. Zamora Zeledón José , Trotochaud Lena , Sartori Andrea , Mirolo Marta , Barkholt Moss Asger , Garg Sahil , Chorkendorff Ib , Drnec Jakub , Seger Brian , Xu Qiucheng
Published: October 2023

In zero-gap CO2 electrolyzers, maintaining the balance of water and cations is crucial. Excessive accumulation at the cathode causes performance degradation, leading to flooding and salt precipitation. Using operando wide-angle X-ray scattering and X-ray fluorescence techniques, we observed the dynamic evolution of H2O and Cs+ inside a membrane-electrode-assembly. Our findings reveal that Cs+ movement across the membrane from the anode to the cathode is governed by migration and drags H2O via electroosmosis. H2O diffusion then allows Cs+ diffusion further within the gas diffusion electrode. When decreasing the applied voltage, the concentration gradient causes Cs+ quickly to diffuse back to the anode. The H2O content in the macro-porous layer remains at the same level, thus showcasing an origin of gas diffusion electrode flooding. By regulating the electrolyte concentration, we deconvolute the correlation of water and cations for selectivity changes. Our work underscores the significance of water/cation management strategies in zero-gap electrolyzers.
Deciphering Trends in Structural Parameters of RE-UiO-66 Metal–Organic Frameworks through Single Crystal Analysis
Authors: Donnarumma P. Rafael , Copeman Christopher , Richezzi Micaela , Sardilli Justin , Titi Hatem M. , Howarth Ashlee J.
Published: October 2023

Single crystals of a family of rare-earth metal–organic frameworks (RE-MOFs), RE-UiO-66 where RE = Sm(III), Eu(III), Gd(III), Tb(III), Dy(III), Ho(III), Er(III), Tm(III), Yb(III), and Lu(III), are successfully synthesized and their structures re-solved through single-crystal X-ray diffraction. Different structural parameters including unit cell dimensions and bond distances are explored to discover trends between those structural parameters, ionic radii of the RE ions in the MOF structures, and their thermal stability. Results suggest that subtle differences in metal-linker bond length can have a notable effect on thermal stability (+/- 60 °C).
Long-term performance of epoxy-based coatings: Hydrothermal exposure
Authors: Zargarnezhad Hossein , Wong Dennis , Lam C.N. Catherine , Asselin Edouard
Published: October 2023

We examined the effects of prolonged exposure to high temperature and water on epoxy-based powder barrier coatings applied to steel panels, which are commonly used in many industrial applications including oil & gas pipelines. The coatings’ performance was evaluated over 85 weeks at 65°C using deionized water. We also compared the mass transport properties of free-standing coating films with the barrier performance of the coated steel panels. This research lays the groundwork for predicting cumulative damage and time-dependent barrier performance of defect-free coating systems. Despite the fact that these coating systems are intended for decades of in-service use, we found that degradation effects caused by permeant sorption within the coatings can be detected as early as 8 weeks in the ageing process. The first 200 days of exposure emerged as critical for underlying corrosion reactions, marking the completion of epoxy network degradation and the onset of a steady state in mass transport mechanisms. Despite the protective barrier coatings, we observed readily occurring under-coating oxidation of the steel substrate after 182 days, as confirmed by cross-sectional and focused ion beam milling analysis. We also analyzed the adhesion strength of the coated panels over time. The epoxy-based coating’s pull-off strength declines rapidly due to water-induced plasticization, but the adhesion properties of the epoxy network show a slight recovery due to secondary cross-linking by Type II bound water. This study underscores the complexity associated with predicting the time-to-failure for epoxy coating systems. However, the data and analyses provided herein offer valuable insights into the implications of extreme exposure conditions, aiding in the construction of lifetime predictions using a stochastic process. In real-world scenarios, pipelines undergo various fluctuations in parameters like temperature and humidity, potentially leading to failure. A deterministic physical/chemical model under simplified conditions can serve as input for the probability distribution function of future failure events.
Advancements of Upper Limb Prostheses can Improve Patient Quality of Life: A Technology Review
Authors: Makwanda Anthony B. , Ikhile Anne O.
Published: October 2023

Introduction: Based on the evolution of hand prosthetics, many original shortcomings have been addressed and further rectified. Some common past limitations include limited degrees of freedom, strained motion control/fine movements, the weight of the design, and lack of ability to do thumb-index pinch. Henceforth, this review highlights and assesses the effects of hand- prosthetics advancements on the quality of life of patients with/requiring joint replacements. Methods: Relevant literature between 2013 to 2023 was obtained using Web of Science and PubMed. Search terms were “Upper limb prostheses” OR “Body replacement technologies” AND “technology” as well as “Upper limb prostheses” AND “technology” AND “Quality of life” OR “Improvement”. Literature was selected based on applicability to key aspects of the research topic after assessing the results and abstracts. Results: Studies support the theory that over the decade, the ability to accomplish fine motion control with hand-prosthetics has aided in improving patients' quality of life. Overall, advancements to prosthetic design, prosthetic sensors, and waterproofing designs via myoelectricity, insulated and biopotential sensors, as well as waterproofing technologies, were reported to contribute greatly to patients’ quality of life. Discussion: As technological advances aid in improved dexterity and motility, recently advanced prosthetics help promote independence and confidence, and in some cases, decrease the cost of living for some patients. Myoelectric prostheses, flexible insulated sensors, capacitive biopotential sensors, and waterproofing technologies, have shown trends in increased dexterity, patient comfort and flexibility, as well as increased degrees of freedom of movement. The most notable limitations to these advancements were limited accessibility, comfort challenges, and lack of large-scale patient assessment. Hence, future advancements in further research and patient testing of these technologies were suggested. Conclusion: This review will be deemed as supporting material for healthcare providers and policy makers while making decisions on the allocation of resources to ensure that patients from all demographics can acquire accessible technologies, improving their qualities of life. In addition, the advancements of hand prosthetic technologies from mechanics and robotics research can provide implications for the next-generation technologies with the determination to improve patients’ life.
The Paradox Paradox Non-Paradox and Conjunction Fallacy Non-Fallacy
Authors: Greenstein Noah
Published: October 2023

Brock and Glasgow recently introduced a new definition of paradox and argue that this conception of paradox itself leads to paradox, the so-called Paradox Paradox. I show that they beg the questions during the course of their argument, but, more importantly, do so in a philosophically interesting way: it reveals a counterexample to the equivalence between being a logical truth and having a probability of one.  This has consequences regarding norms of rationality, undermining the grounds for the Conjunction Fallacy.
Countering Justification Holism in the Epistemology of Logic: The Argument from Pre-Theoretic Universality
Authors: Andersen Frederik J.
Published: October 2023

A key question in the philosophy of logic is how we have epistemic justification for claims about logical entailment (assuming we have such justification at all). Justification holism asserts that claims of logical entailment can only be justified in the context of an entire logical theory, e.g., classical, intuitionistic, paraconsistent, paracomplete etc. According to holism, claims of logical entailment cannot be atomistically justified as isolated statements, independently of theory choice. At present there is a developing interest in—and endorsement of—justification holism due to the revival of an abductivist approach to the epistemology of logic. This paper presents an argument against holism by establishing a foundational entailment-sentence of deduction which is justified independently of theory choice and outside the context of a whole logical theory.