bluuebunny/crossref_metadata_2025 huggingface dataset:
A cross sectional study of cutaneous manifestations in 300 patients of diabetes mellitus
Authors: Khuraiya Sandeep , Lal Nancy , . Naseerudin , Jain Vinod , Kachhawa Dilip
Published: January 2019

Background: Diabetes Mellitus (DM) is a worldwide problem and one of the most common endocrine disorder. The skin is affected by both the acute metabolic derangements and the chronic degenerative complications of diabetes.Methods: The present study was a one-year cross sectional study from January 2014 to December 2014. All confirmed cases of DM with cutaneous manifestations irrespective of age, sex, duration of illness and associated diseases, willing to participate in the study were included in the study. Routine haematological and urine investigations, FBS, RBS and HbA1c levels were carried out in all patients.Results: A total of 300 patients of diabetes mellitus with cutaneous manifestations were studied. Majority belonged to the 4th decade (33%) and 3rd decade (27.7%) respectively. Males constituted 65% of the cases and male to female ratio was 1.85:1. Type 2 DM was most commonly observed (96%). Among the 300 diabetic patients, 73 patients (24.3%) had good control of DM with HbA1c levels in the range of 6.5-7% while 132 patients (44%) had a poor control of DM with HbA1c levels >8%. Hypertension was the most commonly associated systemic illness (37.6%). Cutaneous infections (63%) were the most commonly observed manifestation of which fungal infections (35.3%) were most frequently observed. Some of the other dermatoses observed were generalized pruritus (15.3%), acrochordons (11%), acanthosis nigricans (6%), diabetic dermopathy (5.33%), diabetic foot (3%), peripheral vascular disease (2.66%), vitiligo (2.66%), xanthelasma palpebrarum (2.33%), diabetic bullae (1%). Cutaneous infections, dermatoses associated with microangiopathy were more common in the uncontrolled diabetic patients which was statistically significant.Conclusions: Infections were the most common cutaneous manifestations in diabetics followed by dermatoses most commonly associated with diabetes. Proper skin care and long-term control of blood glucose levels may reduce the risk of some of the skin diseases.
Study of spectrum of sepsis and prediction of its outcome in patients admitted to ICU using different scoring systems
Authors: K. Ravi , K. Vinay , K. Akhila Rao
Published: January 2019

Background: Although sepsis is one of the leading causes of mortality in hospitalized patients, information regarding early predictive factors for mortality and morbidity is limited. The aim was to identify reliable and early prognostic variables predicting mortality in patients admitted to ICU with sepsis.Methods: Patients fulfilling the Surviving Sepsis Campaign 2012 guidelines criteria for sepsis within the ICU were included over two years. Apart from baseline haematological, biochemical and metabolic parameters, APACHE II, SAPS II and SOFA scores were calculated on day 1 of admission. Patients were followed till death or discharge from the ICU. Chi-square test, student t-test, receiver operating curve analyses were done.Results: 100 patients were enrolled during the study period. The overall mortality was 35% (68.6% in males and 31.4% in females). Mortality was 88.6% and 11.4% in patients with septic shock and severe sepsis and none in the sepsis group, respectively. On multivariate analysis, significant predictors of mortality were APACHE II score greater than 27, SAPS II score greater than 43 and SOFA score greater than 11 on day the of admission. On ROC analysis APACHE II had the highest sensitivity (92.3%) and SAPS II had the highest specificity (82.9%).Conclusions: All three scores performed well in predicting the mortality. Overall, APACHE II had highest sensitivity, hence was the best predictor of mortality in critically ill patients. SAPS II had the highest specificity, hence it predicted improvement better than death. SOFA had intermediate sensitivity and specificity.
Oropharyngeal candidiasis in HIV/AIDS patients and HIVfree subjects in the Southeast of Iran
Authors: Hosain Pour Abbas , Salari Samira , Ghasemi Nejad Almani Pooya
Published: January 2019

Background and Purpose: Candida species are the common opportunistic pathogens during the course of human immunodeficiency virus (HIV) infection. Oropharyngeal candidiasis (OPC) is generally known as the initial sign of HIV infection. The aim of this study was to compare demographic characteristics and frequency of Candida species between HIV/AIDS patients and HIV-free subjects in Kerman, southeast of Iran. Materials and Methods: This study was conducted on 143 samples collected from the oral cavity of 81 HIV/AIDS patients and 35 HIV-free subjects. The samples were cultured on Sabouraud dextrose agar and CHROMagar. The identification of Candida species was accomplished using the color of colony and polymerase chain reactionrestriction fragment length polymorphism. Results: According to the results, C. albicans (n=25, 69.14%) was the most prevalent species isolated from the HIV/AIDS patients, followed by C. glabrata (n=19, 23.46%). Other isolated species included C. parapsilosis (n=4, 4.94 %), C. krusei (n=1, 1.24%), and C. kefyr (n=1, 1.24%). Out of the 35 Candida species recovered from the oral samples of HIV-free subjects, 23 (65.71%) and 12 (34.29%) cases were C. krusei and C. albicans, respectively. Candida krusei was the only non-albicans species found in the HIV-free subjects that was also the predominant isolated species. Regarding the HIV/AIDS patients, the highest prevalence of OPC was observed in the age group of 4150 years. However, in the HIV-free subjects, the age group of 31-40 years had the highest prevalence of this infection. Furthermore, no correlation was observed between the gender and number of Candida isolates. Conclusion: Consideration of the epidemiologic data showed that the two groups were significantly different in terms of the prevalence of Candida species, which could play a major role in the selection of effective drugs for the treatment of candidiasis
W stronę socjologii artystki
Authors: Wejbert-Wąsiewicz Ewelina
Published: January 2019

Artykuł jest szkicem odwołującym się do płaszczyzny socjologii kultury i sztuki, historii sztuki. Materiał źródłowy stanowiły różnego rodzaju studia i teksty: opracowania historyczne, artykuły naukowe, wystawy malarstwa i albumy, recenzje, biografie. Celem artykułu jest analiza funkcjonowania artystek z Europy w polu sztuki w przeszłości i współcześnie na przykładzie literatury i sztuk plastycznych. Tekst ma charakter szkicu, dotyczy socjologii artystki, w tym powiązań sztuki i feminizmu. W rozważaniach zwrócono szczególną uwagę na kwestię roli społeczno-kulturowej kobiet, zwłaszcza w aspekcie autonomii, autorytetu i zobowiązań.
Interpretacja sytuacji ekonomicznej artystów współczesnych w Polsce w świetle koncepcji anomii i dewiacji społecznej
Authors: Franckiewicz-Olczak Izabela
Published: January 2019

Przenikanie się świata artystycznego z innymi światami go otaczającymi, szczególnie ze światem wolnorynkowej gospodarki, może powodować anomię i sprzyjać zachowaniom dewiacyjnym. Tekst, w oparciu o typologię mitów związanych z artystami, omawia obszary społecznego ich funkcjonowania, w których zaszły najdalej posunięte zmiany. Odwołując się do teorii dewiacji w interpretatywnym ujęciu Howarda S. Beckera, próbuje wykazać zmienność w czasie i względność dewiacyjności świata artystycznego, a sięgając po Mertonowskie typy idealnego przystosowania, obrazuje sposoby funkcjonowania artystów w bieżącej rzeczywistości społeczno-gospodarczej.
Elżbieta Batory – historia prawdziwa
Authors: Bartosiewicz Aleksandra
Published: January 2019

Niemal każdy słyszał legendę o okrutnej Elżbiecie Batory, która kąpała się we krwi młodych dziewic, by zachować wieczną młodość. Hrabina zapisała się na trwałe w historii jako jedna z najkrwawszych kobiet Europy. Została też wpisana na światową listę rekordów Guinnessa jako największa seryjna morderczyni wszechczasów. Jednak czy aby na pewno dopuściła się wszystkich zarzucanych jej czynów? W artykule przedstawione zostaną dwie wersje historii życia węgierskiej arystokratki: jedna, wywodząca się z legend, oraz druga, oparta na faktach, do których udało się dotrzeć współczesnym badaczom tematu.
ЛЕМКІВСЬКИЙ СУБСТРАТ В ПОЕЗІЇ Б. І. АНТОНИЧА І Й. ГАРАСИМОВИЧА
Authors: Тамаш Юлиян
Published: January 2019

Богдан Ігор Антонич (1909–1937) пише поезію українською, а Ї. Гараси- мович (1933–1999) польською мовою. Без огляду на приналежність різним національним і поетичним традиціям, їм спільна мифотворчість природи. Оба плекають поетику простору. Перший називає її зеленою біблією, другий – країною лагідності. Їм спільний лемківський природний, культурний і поетичний субстрат. Під лемківським субстра- том розуміємо лат. scintilla lirica – коломийка, краков’як, в основі емоціоналізації світу, відсутність героїчної моделлі світу, розщеплення суспільного і історичного єства поміж цивілізаційними моделяями Сходу і Заходу, приналежність греко-католицькій церкві в материкових землях та в россіянні як творення недокінченого екуменізму, посе- редництвом якого здійснювалася денаціоналізація лемків на рахунок державотворних народів в оточенні. В цих межах українська культурна традиція переважає, хоча у материкових землях і у розсіянні з’явлюються перехідні форми наближення східнослов’янської основи до західнослов’янських та південнослов’янських традицій.
Nohut (Cicer arietinum L.)’ta Solgunluğa Neden Olan Fusarium oxysporum’un Biyolojik Mücadelesi
Authors: AYDIN Mehmet Hadi
Published: January 2019

Bu çalışma, nohut solgunluk hastalığına neden olan Fusarium oxysporum’a karşı bazı Trichoderma
türlerinin etkinliğini belirlemek amacıyla 2017-2018 yılları arasında in vivo
ve in vitro koşullarında yürütülmüştür. F. oxysporum’un N5 ve N7 izolatına karşı, PDA
besiyerinde, ikili kültür yöntemine göre, 
22 ± 24 oC’de yürütülen denemede, en etkili izolatlar
sırasıyla T. hamatum ÖT 16, T. asperellum ÖT1, T. strigosum LO43, T. gamsii VG47 ve T. gamsii VG48 olarak belirlenmiştir. İn vivo koşullarında ise,
bulaşık saksı toprağında, nohut tohumlarına antagonist uygulayarak yürütülmüştür.
Trichoderma’ların nohut solgunluk
patojenlerini farklı oranlarda etkilediği, en etkili izolatların ise sırasıyla T. hamatum ÖT16, T.viride VG18, T. gamsii VG47
olduğu tespit edilmiştir. Çalışmada, nohut solgunluk hastalığına karşı
biyolojik mücadelede,  Trichoderma’ların etkili olduğu sonucuna
varılmıştır.
Fluctuation of Insect Population on Rice Field in Pangkalan Sub-district Karawang Regency: Indicator for Environmental Health
Authors: Afifah Lutfi , Sugiono Darso
Published: January 2019

Pangkalan Sub-district is a forest edge area in Karawang that is rich in flora and fauna that has not been much identified. Because of its unique location that is bordered by primary forest, agricultural ecosystems in the area will not be separated from the influence of the surrounding forest. So, it is necessary to know more about the diversity and abundance of insects in the wetland rice ecosystems.The research was conducted in Pangkalan sub-district, Karawang regency. The size of each plot was 5 x 5 m (25 m2) and each treatment was repeated five times. Treatments carried out with integrated pest management (IPM), chemical pest management techniques (P-K), and Mixed Pest Management (P-C). Insect retrieval technique using sweep net method, yellow pan trap, and direct observation. The abundance of arthropod species found in 12 Orders consist of: Thysanoptera Order (2.4%), Orthoptera (0.5%), Odonata (1.4%), Mantodea (0%), Lepidoptera (8.7%), Hymenoptera (2.4%), Hemiptera (61.8%), Diptera (2.4%), Derma ptera (3.6%), Coleoptera (8.3%), Architaenioglossa (0.5%), and Aranea (8.0%). Based on the species richness, it was found that the orders of Diptera (25 species), Coleoptera (19 species), and Hymenoptera (18 species) showed higher numbers than other orders. The H 'diversity index in this study ranged from 1.99 to 2.45, the D index ranged from 0.73 to 0.88, and the E index ranged from 0.5 to 0.7. Overall the P-K plots showed a lower population abundance compared to IPM and P-C plots. Intense and scheduled spraying of insecticides on P-K plots causes a lower population abundance, which makes the diversity become low. Keywords: Rice pests, diversity of insects, natural enemies, pesticides, integrated pest control (IPM)
Modelling Inflation Sectors in Indonesia Using Vector Autoregressive (VAR)
Authors: Prahutama Alan , Suparti S. , Ispriyanti Dwi , Utami Tiani Wahyu
Published: January 2019

Analisis time series dapat dibagi menjadi dua yaitu analisis time series univariat dan analisis time series multivariat. Analisis time series univariat salah satunya menggunakan ARIMA, sedangkan analisis time series multivariat dapat menggunakan VAR. VAR merupakan pemodelan persamaan simultan yang memiliki beberapa variabel endogen secara bersamaan. Asumsi dalam model VAR antara lain terjadi kausalitas antar variabel (kausalitas Granger), residual white noise dan berdistribusi normal multivariat. Pada paper ini, metode VAR diimplementasikan dalam memodelkan sektor-sektor Inflasi di Indonesia. Adapun sektor-sektor tersebut antara lain sektor makanan (Y1t),Sektor Makanan Jadi, Minuman, Rokok dan Tembakau (Y2), Sektor perumahan, listrik, air, gas dan bahan bakar (Y3), Sektor Sandang (Y4), Sektor Kesehatan (Y5), Sektor Pendidikan dan Olahraga (Y6), Sektor Transportasi, Komunikasi dan Jasa Keuangan (Y7). Hasilnya adalah tidak semua variabel sektor inflasi berpengaruh terhadap sektor lainnya. Hanya beberapa variabel yang berpengaruh terhadap suatu sektor. Asumsi kausalitas Granger tidak semua dipenuhi oleh semua variabel. Begitu juga dengan normal multivariat juga tidak terpenuhi. Akan tetapi residual model sudah white noise. Keywords: vector autoregressive model, sectors of inflation, Granger Causality.
Synthesis of Nanosilica from Padas Stone to Reduce The Total Organic Carbon of Palm Oil Waste
Authors: Shofiyani Anis , Chitra Fara , Rahmalia Winda , Rudiyansyah R. , Alimuddin Andi Hairil
Published: January 2019

Padas stone is one of the natural mineral containing 67.5% of SiO2 compounds. In this research, synthesis of nanosilica was carried out by sol-gel method asistanced by 2.45 GHz microwave radiations with low (10%), medium (50%) and high (100%) power at 30 and 60 minutes of contact times. It was analyzed by XRD, BET, FTIR spectrophotometry and SEM. The synthesized silica was then used as absorbent for total organic carbon (TOC) of palm oil waste. The results show that the synthesized silica was a mixture of cristobalite and quartz type minerals according to ICDD No. 00-003-0271 and 01-083-287. The surface area and silicon dioxide contains are 12.174 m2/g and 76.325% for silica without microwave assistance (SiO2-TPMW); 12.796 m2/gand 86.385% for silica with 30 minutes on 10% microwave assistance(SiO2 -MW 10A); 12.735 m2/gand 86.254% for silica with 60 minutes on 10% microwave assistance (MW 10B); 13,659 m2/gand 87.211% for MW 50A; 13,583 m2/g and 86.684% for MW 50B;7.883 m2/gand 57.527% for MW 100A; also 8.752 m2/g and 37.725% for MW 100B, respectively. The use of silica as an absorbent of TOC shows the effectiveness of 62.89% (TPMW); 63.68% (MW 10A); 62.96% (MW 10B); 65.25% (MW 50A); 64.61% (MW 50B); 62.37% (MW 100A) and 61.18% (MW 100B) from the initial TOC of 1520 mg/L. Keywords: synthesis, nanosilica, padas stone, total organic carbon, oil waste.
Experimental Study of TiO2 Nanoparticles Fabrication by Sol-gel and Co-precipitation Methods for TiO2/SnO2 Composite Thin Film as Photoanode
Authors: Endarko E. , Adawiyah Siti Rabi’atul
Published: January 2019

Sol-gel and coprecipitation methods successfully prepared titanium dioxide (TiO2) powders with anatase structure. The TiO2 powders are then used to fabricate pure TiO2 thin-film or mixed with SnO2 powders for the TiO2/SnO2 composite thin film. Furthermore, the structural, morphological, as well as the optical properties of films were also investigated. The results showed that the synthesized thin-film of TiO2 powders by sol-gel method obtained better crystallinity and microstructure compared to the synthesized thin film by co-precipitation method. In the DSSC system, these features are needed to increase the electron mobility that responsibility for transport and recombination of photoexcited electrons. SEM images exhibited the smooth surface and uniform in particle size obtained by the addition of SnO2 powders in composite films. The composite thin film also indicated a higher transmittance value. Keywords: sol-gel,co-precipitation,anatase, composite.
PRODIG (Prevention of new onset diabetes after transplantation by a short term treatment of Vildagliptin in the early renal post-transplant period) study study protocol for a randomized controlled study
Authors: Gaiffe Emilie , Crepin Thomas , Bamoulid Jamal , Courivaud Cécile , Büchler Matthias , Cassuto Elisabeth , Albano Laetitia , Chemouny Jonathan , Choukroun Gabriel , Hazzan Marc , Kessler Laurence , Legendre Christophe , Meur Yannick Le , Ouali Nacera , Thierry Antoine , Anota Amélie , Nerich Virginie , Limat Samuel , Bonnetain Franck , Vernerey Dewi , Ducloux Didier
Published: January 2019

Background: Post-transplant diabetes is a frequent and serious complication of kidney transplantation. There is currently no treatment to prevent or delay the disease. Nevertheless, identification of risk factors make possible to target a population at risk to develop de novo diabetes. We hypothesized that a short term treatment with Vildagliptin may prevent new onset diabetes after transplantation (NODAT) in high-risk patients.
Methods: This is a multicenter double-blind placebo-controlled randomized clinical trial. Patients undergoing first kidney transplantation will be included in 10 French transplant center. Included patients will be randomized (1:1) to receive either vildagliptin 100 or 50 mg/day (depending on glomerular filtration rate) during 2 months (the first dose being administered before entering the operating blocks) or placebo. Additional antidiabetic therapy could be administered according to glycemic control. The primary outcome is the proportion of diabetic patients 1 year after transplantation, defined as patients receiving a diabetic treatment, or having a fasting glucose above 7 mmol/l, or/and with an abnormal oral glucose tolerance test. Secondary outcomes include the glycated hemoglobin, the occurrence of acute rejection, infection, graft loss and patient death at 3 months, 6 months and 12 months after transplantation. The results will be correlated to clinical and general characteristics of the patient, cardiovascular history, nephropathy, dialysis history, transplantation data, biological data, the health-related quality of life and the cost-effectiveness of prevention of diabetes with vildagliptin.
Discussion: There are only few data concerning pharmacological prevention of post-transplant diabetes. If our hypothesis is verified, our results will have a direct application in clinical practice and could limit diabetes-associated morbidity, reduce cardiovascular complications, increase quality of life of renal transplant patients, and consequently promote graft and patient survival. Our results may possibly serve for non-transplant patients carrying a high-risk of diabetes associated with other co-morbidities.
Trial registration: ClinicalTrials.gov, NCT02849899 Registered on 8 February 2016.
Keywords: Diabetes prevention; Vildagliptin; kidney transplantation; randomized controlled trial.
A patient with epilepsy suffering from repeatedly hyperbilirubinemia caused by Gilbert Syndrome: a case report and literatures review
Authors: Zhang Yao-yao , Jiang Yong-li , Song Chang-geng , Zhao Zhi-han , Yuan Fang , Yang Fang , Jiang Wen
Published: January 2019

Background: Certain antiepileptic drugs (AEDs) such as valproic acid (VPA) and lamotrigine (LTG) would bring some abnormalities on liver function, ranging from mild malfunction of liver tests to serious hepatotoxicity. The former manifests temporary and reversible elevation of bilirubin and liver enzyme, which is usually dose-dependent and the abnormality can return to normal shortly after the drug was withdrawn. Levetiracetam (LEV), as a newly broad-spectrum AED with relatively fewer side-effects and fewer drug interactions, is increasingly used as adjunctive therapy to treat generalized epilepsy. Gilbert syndrome（GS）is characterized by mild, chronic, intermittent unconjugated hyperbilirubinemia without other hepatic diseases. Fasting, stress, along with some liver toxic drugs would make it clinically apparent. However, when GS co-exists with epilepsy, how to differentiate which one is responsible for the abnormality of bilirubin poses a challenge to us. We herein describes a patient with epilepsy complicated by mildly and intermittently elevated bilirubin, and after various examinations especially for whole-exome sequencing（WES）and liver biopsy, we made a definite diagnosis of GS.
Case presentation: A 25-year-old male with epilepsy suffering from intermittently and mildly elevated bilirubin, and relevant imaging information led us consider the diagnosis of idiopathic generalized epilepsy (IGE). After administration of AEDs, the indirect bilirubin remained still slightly elevated even while taking LEV. Then he was referred to the department of gastroenterology in our hospital, the results of diagnostic tests, clinical manifestation, imaging studies, WES and liver biopsy all made contributions to our diagnosis of GS rather than the hepatic injury induced by AEDs.
Conclusions: This report presents us with a case of an epilepsy patient complicated by repeatedly elevated bilirubin and finally was diagnosed with GS. By referring to literatures and genetic testing, though, no shared genetic and pathophysiological basis between epilepsy and GS was found, and enzymes responsible for the metabolism of AEDs took no part in the pathogenesis of GS. Our experiences will help clinicians to better differentiate the etiology of repeatedly elevated bilirubin of epilepsy patients during the process of treatment.
Key words: Epilepsy, Gilbert syndrome, Valproic acid, Lamotrigine, Levetiracetam, hyperbilirubinemia.
Effectiveness of Yi-Zhi-An-Shen Granules on cognition and sleep quality in older adults with amnestic mild cognitive impairment: protocol for a randomized, double-blind, placebo-controlled trial
Authors: Yue Shengnan , He Ting , Li Baiyang , Qu Yanqin , Peng Hongmei , Chen Jinxin , Lei Ming , Chen Chongli , Wu Wenbin
Published: January 2019

Background: Amnestic mild cognitive impairment (aMCI) is a syndrome characterized by significant forgetfulness that does not meet the criteria of dementia. Individuals with aMCI are at a bigger risk of progressing to dementia. Current studies suggest good sleep quality is linked with preserved cognition in the elderly, and sleep complaints are common among the elderly with amnesia. Therefore, improving their sleep may be helpful for maintaining and improving their cognitive capacity. According to the theory of traditional Chinese medicine, Yi-Zhi-An-Shen is an herbal compound which may ameliorate forgetfulness and sleep disorders. As growing evidence indicates that gut microbiome is associated with major mental symptoms, a hypothesis was proposed that Yi-Zhi-An-Shen Granules (YZASG) might work by alternating microbial abundance and diversity. In this study, the investigators intend to assess the efficacy of YZASG on global cognition in the elderly suffering from aMCI, and evaluate its safety as well as its potential mechanisms via sleep quality, fecal microbial 16SrDNA and metagenomics analyses, and serum markers.
Methods: This is a randomized, double-blind, placebo-controlled clinical trial. A total of 80 patients (aged 60~85 years) will be recruited and allocated randomly to a treatment group and a placebo-matched group in a 1:1 ratio, then will be administered YZASG or isodose placebo three times a day. The intervention course is 16 weeks, with an 18-month follow-up. The primary outcome is Alzheimer Disease Assessment Scale-Cognitive subscale (ADAS-cog11). Secondary outcome measures are mini-mental state examination (MMSE), Montreal cognitive assessment (MoCA), Pittsburgh Sleep Quality Index (PSQI), serum concentrations of immunological factors and inflammatory cytokines, fecal microbiota. Fecal microbiota will only be collected at the baseline and endpoint of the intervention.
Discussion: The results of this trial will be conducive to assessing the safety and effectiveness on cognition of YZASG in intervening aMCI among the elderly and determining if it takes effect via the improvement of sleep quality, regulation of gut microbita, concentration of certain serum markers.
Trial Registration: ClinicalTrials.gov, ID: NCT03601000. Registered on 26 July 2018.
Keywords: Amnestic Mild cognitive impairment (aMCI), Sleep, Gut microbiome, Older adults
Mares e oceanos: novas fronteiras da regulação territorial?
Authors: Pires do Rio Gisela
Published: January 2019

Os espaços marítimos ganharam relevância no período atual pela importância dos transportes e telecomunicações, potencial de recursos que abriga, pelo papel que desempenham na dinâmica da circulação atmosférica ou ainda pela diversidade de ecossistemas e espécies que abrigam. São espaços cobiçados e disputados e, por isso, objeto de regulação em diferentes esferas. Como espaço privilegiado da globalização, os espaços marítimos suscitam indagações sobre as diferentes formas de regulação das atividades econômicas e das distintas zonas que lhes assegura a efetiva realização. Este trabalho consiste em primeira aproximação sobre esta fronteira de regulação em sua interface com a terra no Brasil. Empregou-se as noções de maritimidade e litoralidade como base da discussão efetuada.
Pathogenic Genes Selection Model of Genetic Disease based on Network Motifs Slicing Feedback
Authors: Zhang Shengli , Tong Zekun , Yin Haoyu , Feng Yifan
Published: January 2019

Background:

Finding the pathogenic gene is very important for understanding the pathogenesis
of the disease, locating effective drug targets and improving the clinical level of medical treatment.
However, the existing methods for finding the pathogenic genes still have limitations, for instance
the computational complexity is high, and the combination of multiple genes and pathways has
not been considered to search for highly related pathogenic genes and so on.

Methods:

We propose a pathogenic genes selection model of genetic disease based on Network Motifs
Slicing Feedback (NMSF). We find a point set which makes the conductivity of the motif minimum
then use it to substitute for the original gene pathway network. Based on the NMSF, we propose a new
pathogenic genes selection model to expand pathogenic gene set.

Results:

According to the gene set we have obtained, selection of key genes will be more accurate and
convincing. Finally, we use our model to screen the pathogenic genes and key pathways of liver cancer
and lung cancer, and compare the results with the existing methods.

Conclusion:

The main contribution is to provide a method called NMSF which simplifies the gene
pathway network to make the selection of pathogenic gene simple and feasible. The fact shows our result
has a wide coverage and high accuracy and our model has good expeditiousness and robustness.
Eggshell, a Promising Waste in Organic Reactions
Authors: da Silveira Pinto Ligia S. , de Souza Marcus V.N.
Published: January 2019

Today, the chicken egg is consumed worldwide with an annual production on the order of
tons. However, in spite of its importance, problems include the generation of waste due to its shell,
which is composed of calcium carbonate (CaCO3). The application of eggshell waste can be utilized in
different fields, such as chemistry, due to its potential possibilities in different types of chemical reactions.
In this context, the aim of this review is to demonstrate the versatility and applications of this
waste over the last five years in different kinds of chemical reactions.
HAMBATAN PENDIDIKAN KARAKTER DI SEKOLAH ISLAM TERPADU (STUDI KASUS SDIT AL HASNA KLATEN)
Authors: Agustinova Danu Eko
Published: January 2019

Penelitian ini bertujuan untuk menganalisis hambatan yang dialami dalam menanamkan nilai-nilai karakter kepada peserta didik di Sekolah Islam Terpadu. Dimana pada model sekolah ini, pendidikan karakter telah dilaksanakan lebih awal sejak kelahiran model sekolah tersebut. Penelitian ini dilakukan di SDIT Al Hasna Klaten. Metode penelitian ini adalah kualitatif deskriptif dengan strategi yang digunakan adalah studi kasus tunggal. Cuplikan yang digunakan dalam penelitian ini adalah purposive sampling dengan criterion-based selection. Pengumpulan data dilakukan dengan observasi langsung, wawancara mendalam, dan pencatatan dokumen. Validasi data dilaksanakan dengan trianggulasi. Analisis data yang digunakan adalah model analisis interaktif, yaitu pengumpulan data, reduksi data, sajian data dan penarikan kesimpulan. Hasil penelitian ini menyimpulkan bahwa Hambatan yang dialami dalam proses penanaman karakter berasal dari dalam dan dari luar. Hambatan dari dalam meliputi pendidik yang kurang bisa memahami karakteristik masing-masing siswa. Kurangnya sarana penunjang dalam kegiatan pembelajaran. Selain itu, sistem full day itu sendiri yang ternyata memiliki beberapa kelemahan. Sedangkan, hambatan dari luar adalah kurang partisipasi aktif orang tua dalam proses penanaman karakter. Kata Kunci: Pendidikan Karakter, Hambatan, SDIT Al Hasna.
PERSAINGAN ELIT BANGSAWAN DENGAN KELOMPOK TERDIDIK PADA MASA REVOLUSI DI SULAWESI SELATAN
Authors: Najamuddin Najamuddin
Published: January 2019

Penelitian ini bertujuan untuk: (1) Mengetahui latar belakang munculnya elit bangsawan dan kelompok terdidik, (2) Mengungkapkan Konflik antara elit bangsawan dengan kelompok terdidik yang berimplikasi pada peran keduanya di Masa Revolusi di Sulawesi Selatan. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian sejarah. Tahapan dalam penelitiannya yaitu pemilihan topik, mengumpulkan sumber, kritik sumber, interpretasi, dan historiografi. Hasil penelitian menunjukkan bahwa Stratifikasi sosial masyarakat Bugis-Makassar telah memberikan posisi istimewa terhadap kaum bangsawan sebagai elit strategis dari kelompok masyarakat lainnya dalam struktur sosial, dan sebagai pemimpin puncak  dalam struktur politik atau struktur kekuasaan. Ketika elit terdidik tampil dalam Pergerakan Nasional di Sulawesi Selatan bersama elit bangsawan, politik kolonial Belanda berhasil mempolarisasi keduanya menjadi bagian yang terpisah menjadi konflik di awal kemerdekaan RI. Kata Kunci: Elit Bangsawan, Kelompok Terdidik, dan Revolusi di Sulawesi Selatan
KIPRAH AMIR SYARIFFUDIN DALAM POLITIK DAN PEMERINTAHAN SAMPAI TAHUN 1948
Authors: Aman Aman , Zulkarnain Zulkarnain , Ragil Wahyu
Published: January 2019

Penelitian ini bertujuan untuk mengetahui kiprah politik Amir Syariffudin pada pemerintahan dan setelah berakhirnya pemerintahanya 1945-1948. Metode yang digunakan peneliti dalam penulisan sejarah ini adalah metode penelitian menurut Kuntowijoyo. Adapun tahapan penelitian sejarah menurut Kuntowijoyo mempunyai lima tahap yaitu pemilihan topik, heuristik, verifikasi, interpretasi, dan penulisan. Hasil penelitian menunjukkan bahwa Amir Syariffudin memiliki peran yang sangat besar bagi Republik Indonesia. Ia memiliki andil yang besar dalam dinamika pemerintahan Republik Indonesia. Sebagai seorang nasionalis, ia pernah menduduki berbagai jabatan penting. Adapun jabatan penting tersebut antara lain: sebagai menteri penerangan, menteri keamanan, perdana menteri, dan wakil Indonesia dalam Perjanjian Renville. Kata Kunci: Amir Syariffudin, peran, politik, dan pemerintahan.
Pemanfaatan Lahan Milik Pakualaman dan Perubahan Status Kepemilikannya di Pesisir Pantai Desa Glagah, Kecamatan Temon, Kabupaten Kulon Progo
Authors: Trisnawati Diana
Published: January 2019

Penelitian ini bertujuan untuk: (1) Menerangkan perubahan status kepemilikan lahan milik Pakualaman di pesisir pantai Desa Glagah, Kecamatan Temon, Kabupaten Kulon Progo, (2) Menerangkan alasan mengapa lahan milik Pakualaman dijadikan sebagai lahan pertanian dan perumahan, dan (3) Menjelaskan mengenai faktor-faktor yang menyebabkan terjadinya perubahan status kepemilikan tanah Pakualaman di pesisir pantai Desa Glagah, Kecamatan Temon, Kabupaten Kulon Progo. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian kulatitatif. Hasil penelitian menunjukkan bahwa ditinjau dari status kepemilikan tanah, tanah tersebut merupakan hak milik Kraton maupun tanah Pakualaman. Namun, tanah tersebut dimanfaatkan oleh rakyat sebagai tempat mata pencaharian bahkan tempat tinggal mereka. Di antara beberapa tanah milik pakualaman, ada juga yang digunakan sebagai tempat tinggal permanen masyarakat. Tanah yang digunakan masyarakat tersebut berstatus magersari, artinya masyarakat boleh menempati tetapi tetap mengakui bahwa tanah tersebut adalah tanah milik Keraton ataupun Pakualaman. Kata Kunci: lahan, Pakualaman, Perubahan status
PENERAPAN MODEL PROBLEM BASED LEARNING DALAM PEMBELAJARAN SEJARAH UNTUK MENINGKATKAN MOTIVASI DAN PRESTASI BELAJAR SISWA KELAS XI IPS 1 SMAN 1 BUTAR SULAWESI TENGAH
Authors: Aman Kamisa
Published: January 2019

Penelitian ini bertujuan  untuk mengetahui bagaimana penerapan model problem based learning dalam pembelajaran sejarah untuk meningkatkan motivasi dan prestasi belajar siswa kelas XI IPS 1 SMAN 1 Butar. Sulawesi Tengah. Teknik pengumpulan data yang digunakan dalam penelitian ini adalah triangulasi sumber dan triangulasi metode. Analisis data yang digunakan dalam metode ini adalah analisis kualitatif dan analisis kuantitatif Setelah Model Problem Based Learning diterapkan, terjadi peningkatan motivasi belajar siswa telah mencapai 85 % pada siklus 3 dan peningkatan prestasi pada siklus 1 terjadi dari 49,5 menjadi 75. Peningkatan pada siklus 2 terjadi dari 53,5 menjadi 81. Peningkatan prestasi pada siklus 3 terjadi dari 60 menjadi 83. Kendala yang dihadapi dalam penerapan Model Problem Based Learning antara lain kurangnya pemahaman siswa mengenai Model Problem Based Learning pada saat awal, dan terdapat siswa yang tidak bisa bekerjasama dalam kelompok. Kelebihan dari penerapan Model Problem Based Learning  antara lain siswa lebih aktif dalam pembelajaran, kemampuan siswa lebih terasah, siswa dapat melatih kerjasama dalam kelompok, menciptakan semangat kompetisi antar kelompok, dan guru lebih mudah dalam melihat pemahaman siswa dalam materi. Kata kunci: Model Problem Based Learning, Motivasi Belajar, dan Prestasi Belajar Siswa.
REVOLUSI MESIR 23 JULI 1952: BERAKHIRNYA PEMERINTAHAN RAJA FAROUK
Authors: Trisnawati Diana
Published: January 2019

Penelitian ini bertujuan: (1) untuk mengetahui kondisi politik, sosial, dan ekonomi Mesir di bawah pemerintahan Raja Farouk, (2) mengungkapkan peran dan kontribusi gerakan Free Officers dan gerakan Ikhwanul Muslimin dalam menggulingkan kekuasaan Raja Farouk, (3) mengetahui proses terjadinya Revolusi Mesir 23 Juli 1952, dan (4) mengetahui kondisi Mesir pasca Revolusi Mesir 23 Juli 1952. Penelitian ini dilakukan dengan menggunakan metode sejarah kritis seperti yang dijabarkan oleh Kuntowijoyo. Hasil dari penelitian menunjukkan bahwa keadaan politik Mesir masa pemerintahan Raja Farouk banyak mengalami kekacauan, diantaranya sering terjadi pergantian kabinet dalam waktu yang relatif singkat, dan adanya dominasi Inggris yang berperan dalam setiap pengambilan kebijakan pemerintah. Terjadi ketimpangan sosial yang cukup tajam antara golongan elit yang terdiri dari tuan tanah dan pengusaha dengan petani kecil. Keadaan tersebut membuat munculnya banyak kelompok oposisi dalam masyarakat yang diwakili oleh Free Officers dan Ikhwanul Muslimin. Free Officers dan Ikhwanul Muslimin sama-sama merasa prihatin terhadap kondisi Mesir dan memberikan kontribusi yang besar dalam mewujudkan Revolusi Mesir 23 Juli 1952. Revolusi tersebut berhasil dan sekaligus mengakhiri kekuasaan Farouk di Mesir. Pasca revolusi, pemerintahan Mesir dikendalikan oleh Dewan Mangkubumi. Pada tanggal 18 Juni 1953 sistem pemerintahan monarki Mesir diganti dengan republik, sekaligus pengangkatan Muhammad Naguib sebagai presiden. Kata kunci: Revolusi Mesir 23 Juli 1952, Pemerintahan, Raja Farouk
“PENERAPAN METODE TANYA JAWAB UNTUK MENINGKATKAN PEMAHAMAN PESERTA DIDIK PADA MATA PELAJARAN IPS (Sejarah) DI KELAS 9.1 TENTANG PERANG DUNIA II, DI SMPN 16 KOTA BOGOR TAHUN PELAJARAN 2012 / 2013
Authors: Sukriyatun Gunarti
Published: January 2019

Tujuan yang ingin dicapai dalam penelitian ini adalah peserta didik lebih aktif bertanya dalam memecahkan masalah-masalah yang belum dipahami oleh peserta didik selama pelajaran berlangsung, juga menjadi terbiasa untuk menjawab setiap pertanyaan yang diajukan kepada peserta didik, sehingga suasana dalam kelas lebih hidup dan menyenangkan  agar  dapat meningkatkan semangat dalam belajar. Metode yang digunakan dalam penelitian ini adalah metode kualitatif bersifat deskriptif analitis. Melalui penelitian ini, peneliti berusaha memahami dan menafsirkan suatu peristiwa menurut perspektif dan hasil pengamatan, sehingga penulis mendapat gambaran secara menyeluruh mengenai masalah yang diteliti. Kegiatan bertanya jawab dapat lebih memusatkan perhatian peserta didik terhadap materi yang dibahas sehingga peserta didik merasa takut atau malu bila tidak bisa menjawab pertanyaan yang dilontarkan oleh peserta didik lain. Kegiatan bertanya jawab dapat menimbulkan keingintahuan sehingga dapat membangkitkan minat dan perhatian peserta didik terhadap suatu masalah yang sedang dibahas. Kegiatan bertanya jawab dapat mendiagnosis kesulitan belajar selama peserta didik mengikuti proses pembelajaran berlangsung. Kata kunci: Metode Tanya Jawab, Peserta didik, Mata pelajaran IPS (Sejarah)
PERAN MUSEUM SASANA WIRATAMA DALAM MENINGKATKAN RASA CINTA TANAH AIR MASYARAKAT DESA TEGALREJO, KECAMATAN TEGALREJO, YOGYAKARTA
Authors: Herbani Asteria
Published: January 2019

Penelitian ini bertujuan untuk: (1) Mendeskripsikan pendapat masyarakat Desa Tegalrejo Kecamatan Tegalrejo Yogyakarta terhadap keberadaan Museum Sasana Wiratama, dan (2) Menjelaskan upaya pemanfaatan Museum Sasana Wiratama Yogyakarta dalam meningkatkan rasa cinta tanah air masyarakat Desa Tegalrejo Kecamatan Tegalrejo Yogyakarta. Dalam melakukan penelitian ini, penulis menggunakan metode penelitian kualitatif. Pengumpulan data yang digunakan meliputi data primer dan data sekunder. Kegiatan analisis yang dilakukan peneliti meliputi: menangkap, mencatat, menginterp retasikan dan menyajikan informasi.Hasil penelitian menunjukkan bahwa Museum Sasana Wiratama memiliki peranan penting dalam upaya meningkatkan rasa cinta tanah air masyarakat Desa Tegalrejo, Kecamatan Tegalrejo, Yogyakarta. Melalui Museum Sasana Wiratama, masyarakat mampu mengetahui dan memahami sejarah perjuangan Pangeran Diponegoro dan merasa semakin bangga dan cinta terhadap tanah air.Kata kunci: Peran, Museum Sasana Wiratama, rasa cinta tanah air.
MIGRASI ORANG-ORANG MADURA DI UJUNG TIMUR JAWA TIMUR: SUATU KAJIAN SOSIAL EKONOMI
Authors: Hartono Mudji
Published: January 2019

Tulisan ini bertujuan untuk mengungkapkan faktor-faktor penyebab orang-orang Madura bermigrasi ke wilayah ujung timur Jawa Timur. Untuk membahas permasalahan tersebut, penulis menggunakan kerangka pikir push and pull dimana yang berusaha untuk mengungkap kondisi yang melatarbelakangi kehidupan para migran Madura, serta perkembangan ekonomi di daerah ujung timur Jawa Timur. Kajian awal penulis menunjukkan bahwa faktor penyebab orang-orang Madura bermigrasi ke daerah Jawa Timur bagian timur adalah kemiskinan di Madura. Sementara itu Jawa Timur dijadikan daerah tujuan migrasi karena di daerah tersebut sedang dibuka perkebunan -perkebunan baru yang menguntungkan rakyat setempat maupun para migran. Di Jawa Timur bagian timur para migran memperoleh beberapa fasilitas fasilitas antara lain: tanah, hewan ternak untuk mengerjakan tanah, dan pembebasan pajak selama beberapa tahun. Kata kunci: migrasi, Madura, ujung timur Jawa Timur.
PENGGUNAAN MUSEUM SEBAGAI MODEL PEMBELAJARAN OUT-CLASS
Authors: Pinasti V. Indah Sri
Published: January 2019

Penelitian ini bertujuan untuk meningkatkan kualitas pembelajaran mata kuliah Museologi melalui pembelajaran out -class pada Program Studi Pendidikan Sejarah Fakultas Ilmu Sosial dan Ekonomi Universitas Negeri Yogyakarta. Pengembangan model pembelajaran out -class dilatarbelakangi oleh perlunya dinamisasi dalam proses pembelajaran, sehingga dapat meng-hasilkan pembelajaran bermakna, mencari, menemukan, dan memecahkan per-masalahan dalam perkuliahan dengan penerapan metode out-class. Metode yang digunakan dalam penelitian ini adalah penelitian kualitatif. Pengumpulan data dilakukan dengan menggunakan teknik wawancara, observasi, dan hasil ujian mahasiswa dalam mata kuliah museologi. Hasil penelitian ini menunjukkan bahwa terjadi peningkatan kualitas pembelajaran pada mahasiswa semester gasal yang mengambil mata kuliah Museologi melalui pengembangan dan penerapan model pembelajaran out-class.Diperoleh kesimpulan bahwa dari penelitian ini berhasil meng-indentifikasi museum-museum yang ada di Yogyakarta. Dari beberapa museum yang berhasil diidentitikasi tersebut hanya terdapat beberapa museum yang efektif dan relevan untuk dijadikan sumber belajar siswa dalam mata kuliah Museologi. Kata Kunci: Pembelajaran Bermakna, Museum
Is There A Link Between Increased Growth and Reduced Income Inequality?: Analysis of Cross-Country Studies
Authors: Wahyuni Heni
Published: January 2019

Hubungan antara pertumbuhan ekonomi dan kesenjangan pendapatan selalu menjadi perdebatan. Perdebatan ini selalu muncul dengan pertanyaan, apakah ada hubungan antara meningkatnya pertumbuhan ekonomi dengan menurunnya kesenjangan pendapatan. Essai ini mereviu perdebatan ini melalui studi pengalaman beberapa negara dan menganalisis apakah ada hubungan antara pertumbuhan dan kesenjangan di negara-negara tersebut. Namun demikian, diskusi yang disampaikan tidak hanya mencakup analisis apakah ada hubungan tersebut atau tidak, tetapi juga yang lebih penting adalah penekanan terhadap kesenjangan dalam masyarakat yang paling miskin. Ini berarti bahwa, mencari  mekanisme untuk meningkatkan kondisi "si miskin" menjadi lebih baik, sehingga dapat menurunkan kesenjangan antara golongan miskin dengan kaya yang pada akhirnya dapat mewujudkan pemerataan pendapatan yang lebih baik. Dalam essai ini juga dipresentasikan usulan kebijakan yang menekankan pada kebijakan ekonomi yang menjadikan penduduk miskin sebagai target kebijakan.
Perdagangan Elektronik: Suatu Bentuk Pasar Baru yang Menjanjikan?
Authors: Purnastuti Losina
Published: January 2019

Electronic Commerce is claimed as a form of new market in electronic era. Although most current use of Electronic Commerce occurs at the inter-corporate and inter-organizational levels, Electronic Commerce services aimed at individual consumers are developing rapidly. The internet is a major catalyst in the diffusion of Electronic commerce into an increasing number of economic spheres, and is rapidly harmonizing the general environment in which electronic transactions of all kinds take place. This form of new market is able to create some incentives both in transaction management and business efficiency area. On the other hand, implementation of Electronic Commerce become an issue discussed extensively from many of point of view including: law, economic and technology.
Strategi Pemberdayaan Usaha Kecil dan Menengah
Authors: Sukidjo -
Published: January 2019

Economic crisis in Indonesia shows that economic development paradigm with trickle down effect strategy, which give a priority to conglomerate economic role is not suitable strategy, since it can not provide strong economic foundation. During economic crisis, conglomerates economic experienced of bankruptcy and negative economic growth; on the contrary small and medium business (enterprise) survived even it was able to lead economic to recovery process. Small and medium business have important role in reducing unemployment, equalizing income distribution, and reducing urbanization rate. However, small and medium business face many problems, such as: lack of capital, marketing limitation, and  low quality of human resources and used technology.  Considering how important role of small and medium business and many problem faced by them  so that it is need to enhance government support.
Currency Board Arrangements: Arguments For and Against Adoption in Indonesia
Authors: Suyanto -
Published: January 2019

Tulisan ini mendiskusikan argumen-argumen pro-kontra  perancangan “currency board“ di Indonesia. Pada waktu krisis ekonomi melanda Indonesia, pemerintah pernah mempertimbangkan kemungkinan pengadopsian “currency board“ guna mengatasi krisis dan menstabilkan perekonomian. Berdasarkan perdebatan panjang mengenai keuntungan dan kerugian penerapan “currency board“ di Indonesia, dapat disimpulkan bahwasanya “necessary condition“ bagi Indonesia untuk mengadopsi “currency board“ selama krisis tidak terpenuhi. Indonesia tidak mempunyai cukup cadangan valuta asing untuk menyokong basis moneter dan sistem perbankan belum siap menerima kondisi “no the lender of last resort.” Keputusan untuk tidak menerapkan “currency board” selama krisis ekonomi merupakan keputusan yang rasional.
Perilaku Investasi di Indonesia: Kajian Jangka Pendek dan Jangka Panjang
Authors: Wahyuni Daru
Published: January 2019

The purpose of this research was to know how domestic investment in Indonesia behaves both in the short term and in the long term. Data used were secondary data obtained from various sources. Those data would be analyzed by using a dynamic analysis tool consisted of a cointegration approach and an error correction model.Several findings obtained from this research were (1) ECT coefficient (4.16) significantly and  statistically influenced domestic investment in Indonesia. It indicated that the error correction model used in this research was valid. (2) In the short term, national income variables and domestic interest rates did not significantly affect domestic investment while government investment variables and rate of exchange positively and significantly influenced domestic investment. Elasticity coefficient of the government investment and the exchange rate were –1.44 and 2.34 respectively. (3) By concerning time lag factor, the estimation results showed that the national incomes, the domestic interest rates, the government investment , and  exchange rate of rupiah against US dollar in the previous 1 year significantly affected domestic investment. Their elasticity  were 2.18, -1.18, -2.18 and 1.26 respectively. (4) In the long term, the national income variables and the exchange rate of rupiah against US dollar positively and significantly influenced domestic investment  meanwhile the domestic interest rate variables and the government investment did not significantly influence domestic investment. The elasticity coefficient of the national income and  exchange rate were 3.08 and –2.19 respectively.
Meningkatkan Profesionalisme Guru: Sebuah Harapan
Authors: Muhson Ali
Published: January 2019

The teacher professionalism had to be improved because the teacher had the important roles to improve human resources quality. The several efforts can be done by the teacher is understanding the minimum standard of the profession, completing the teacher qualifications and competencies, creating the good partnership, improving the service-based working, and improving the creativity in use the very latest information and communication technologies. The improving of the teacher welfare supported the several efforts to improve the teacher professionalism.
Sistem Penilaian Pembelajaran Ekonomi Berbasis Kompetensi
Authors: Lestari Barkah
Published: January 2019

Implementasi kurikulum 2004 membawa konsekuensi perubahan pada penilaian pembelajaran ekonomi. Pada kurikulum sebelumnya (kurikulum 1994)  menggunakan penilaian tradisional yang mengandalkan testing pada akhir periode pembelajaran, sementara itu kurikulum 2004 menggunakan penilaian berbasis kompetensi. Penilaian berbasis kompetensi merupakan salah satu komponen yang menjadi pilar kurikulum 2004. Oleh karena sangat pentingnya kedudukan penilaian berbasis kompetensi dalam implementasi kurikulum 2004, maka pemahaman yang mendalam terhadap penilaian berbasis kompetensi  oleh pendidik dan tenaga kependidikan menjadi sangat penting.