bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPORTÂNCIA DA INCLUSÃO COMO MECANISMO DE CONCRETIZAÇÃO DO PRINCÍPIO DA DIGNIDADE DA PESSOA HUMANA ÀS PESSOAS COM DEFICIÊNCIA
Authors: Paiva Wilson Rodolfo , Meireles Anderson , Santos Luiz Márcio dos
Published: September 2023

O objetivo desse artigo é promover, proteger e assegurar o pleno e igual gozo de todos os direitos humanos e liberdades fundamentais para todas as pessoas com deficiência e promover o respeito pela sua dignidade inerente. Pessoas com deficiência são aquelas que possuem uma deficiência física, mental, intelectual ou sensorial de longo prazo, que, em interação com vários obstáculos, pode impedir sua participação plena e efetiva na sociedade em igualdade de condições com as demais pessoas.
FATORES ASSOCIADOS À PREVALÊNCIA DE ABANDONO DO TRATAMENTO DA TUBERCULOSE EM CUIABÁ-MT DE 2010 A 2020
Authors: Costa Isabella Sempio Faria Figueiredo , Souza Camila Santos Alves de , Ruelis Carolina Silva , Machado Daniel Antonio de Alcantara , Botelho Eduarda Regina , Pascoal Geovana Brambilla , Melo Vanessa Machado de , Bello Lucas , Favaro Emerson Giuliano Palacio
Published: September 2023

Objetivo: Descrever o perfil dos casos de abandono do tratamento da tuberculose no período de 2010 a 2020 na cidade de Cuiabá - MT. Métodos: Análise epidemiológica de natureza descritiva observacional, de corte transversal retrospectivo com dados obtidos do Sistema de Informação de Agravos de Notificação (SINAN) entre 2010 e 2020. Foram descritos 6948 casos de tuberculose, dentre esses, 824 de abandono do tratamento. Resultados: Dentre os 6948 casos, a prevalência de abandono foi de cerca de 11,85%, equivalente a 6,8 abandonos por mês, com maior frequência no ano de 2014 de 128 pacientes, cerca de 15,53%. Houve predomínio para o sexo masculino (70,87%), faixa etária de 25 a 34 anos (28,03%), raça parda (54,86%), com ensino fundamental incompleto (41,14%). O tratamento supervisionado (42,48%) foi realizado na maioria dos casos. Na maior parte dos casos o tratamento utilizado foi o de primeira escolha, como rifampicina (52,43%), isoniazida (52,06%), pirazinamida (51,33%) e etambutol (50,36%). Conclusão: Os resultados confirmam grandes variações nos índices de abandono do tratamento ao longo dos anos, configurando como fatores predominantes: sexo masculino, raça parda e ensino fundamental incompleto. Considerando que, a adesão ao tratamento é imprescindível para alcançarmos a meta proposta pelo Ministérios da Saúde, é fundamental conhecer o perfil de paciente que abandona o tratamento da tuberculose para, então possível ajuste terapêutico pode ser, uma estratégia com intuito de minimizar o abandono.
Sensitivity analysis of erosion on the landward slope of an earthen flood defense located in southern France submitted to wave overtopping
Authors: Houdard Clément , Poupardin Adrien , Sergent Philippe , Bennabi Abdelkrim , Jeong Jena
Published: September 2023

Abstract. The study aims to provide a complete analysis framework applied to an earthen dike located in Camargue, France. This dike is regularly submitted to erosion on the landward slope that needs to be repaired.
Improving the resilience of the dike calls for a reliable model of damage frequency. The developed system is a combination of copula theory, empirical wave propagation, and overtopping equations as well as a global sensitivity analysis in order to provide the return period of erosion damage on a set dike while also providing recommendations in order for the dike to be reinforced as well as the model to be self-improved. The global sensitivity analysis requires one to calculate a high number of return periods over random observations of the tested parameters. This gives a distribution of the return periods, providing a more general approach to the behavior of the dike. The results show a return period peak around the 2-year mark, close to reported observation. With the distribution being skewed, the mean value is higher and is thus less reliable as a measure of dike safety. The results of the global sensitivity analysis show that no particular category of dike features contributes significantly more to the uncertainty of the system. The highest contributing factors are the dike height, the critical velocity, and the coefficient of seaward slope roughness. These results underline the importance of good dike characterization in order to improve the predictability of return period estimations. The obtained return periods have been confirmed by current in situ observations, but the uncertainty increases for the most severe events due to the lack of long-term data.
Spatio-Temporal Changes in Patterns of Land Use and Land Cover in Peri - Urban Areas of Faisalabad City
Authors: Afzal Iqra , Waseem Liaqate Ali , Khurshid Madiha , Maqbool Muhammad Shahid
Published: September 2023

The changes in land use occurs with the passage of time in an area where the priorities of living standard changes. The increase in population and better socio-economic opportunities within urban localities influences the peripheral areas as well as the proximities. The aims of the study changes in land use patterns in peri urban areas. The current research evaluated the variation in land use preferences in Faisalabad city during the 2000, 2010 and 2017, covering 18 years. The change is detected through satellite images by applying the supervised classification in specified classes including vegetation, built up areas, barren land and water bodies. The analyses of the acquired images disclosed that the dominant land utilization in the peri-urban zone is the built-up or infrastructure development. This urban expansion and development mostly influenced the agricultural land or vegetation cover, as results vegetation cover reduced rapidly. Out of the total land area, the urban infrastructure area with 24% in 2000, increased to 46% in 2017.  The results further indicated that the city is expanding rapidly towards the peri-urban areas. For the most part of the peri-urban, land is converted to urban land uses as for housing, infrastructure and commercial activities.
Evaluation of Second Canals in Mandibular Incisors using Magnification: A Cross-Sectional Study
Authors: Rozi Afsar  , Ali Asma , Afsar Badshah , Nasir Umar , Maryam Bibi
Published: September 2023

Background: It is essential to have a thorough understanding of the typical anatomy of the root canal system, as well as the various common and uncommon anatomical variations, in order to achieve successful treatment outcomes.Objective: To determine the frequency and pattern of two canals in mandibular incisors using magnifying loupe Material and Methods: This study at Saidu College of Dentistry in Swat included 385 participants selected consecutively. Inclusion criteria were males and females aged 20-60 years with mandibular incisor-related dental conditions. Exclusion criteria were local anesthesia allergies, internal root resorption, calcified canals, and pregnancy. The number of canals was recorded radiographically using the SLOBE technique. Canals were classified using Vertucci's system. Canal frequencies were analyzed by gender and tooth types using chi-square tests (p<0.05).Results: The mean age was 33.97±11.10 years. Of the participants, 215 (55.84%) were males. The highest numbers of tooth types were found among the left lateral incisors (n=148, 38.44%) and left central incisors (n=122, 31.69%). Second canal was found 139 participants (36.10%). Among these, Type I (n=84, 21.82%) was the most common two-canal pattern, followed by Type III (n=36, 9.35%). When analyzing the canal types within the single canal group, Type I was the most prevalent in both males (23.26%) and females (20.00%). The frequencies of Types II, III, and IV were similar between genders and did not exhibit significant differences (p=0.865). The distribution of canal types varied across tooth types, with Type I being the most common, but not statistically significant (p=0.652).Conclusion: The presence of a second canal in the mandibular incisors is quite common. The most common pattern of two canals, according to the Vertucci classification, was Type I, followed by Type III.Keywords: Magnification, Mandibular incisors, Second canals, Vertucci classification
What is Data, Its Type and Summary Statisitcs
Authors: Umar Hussain
Published: September 2023

In medical research, data is collected from various sources, including patient records, clinical trials, surveys, and experiments. Researchers need to accurately classify and analyze this data to draw meaningful conclusions about diseases, treatments, and patient outcomes. Knowing the types of data (nominal, ordinal, interval, and ratio) helps researchers choose appropriate statistical methods for analysis.
Pengaruh Good Corporate Governance, Corporate Risk, dan Capital Intensity Terhadap Tax Avoidance Perusahaan Sub-Sektor Perbankan yang Terdaftar di Bursa Efek Indonesia (BEI)
Authors: Juwita Ratih , Antoni Antoni
Published: September 2023

Tax avoidance is a method of reducing tax legally with the aim of minimizing the tax burden by taking advantage of loopholes in the tax provisions of a country to maximize the amount of profit after tax, because in this case the tax is an element of profit reduction. This research aims to analyze the effect of Good Corporate Governance, corporate risk, and capital intensity on tax avoidance either partially or simultaneously. The population in this research is the banking sub-sector companies listed on the Indonesia Stock Exchange for the 2018-2021 period, totaling 43 companies. The method of determining the sample using the purposive sampling method with several predetermined criteria, there are 10 companies with observations for 4 years, so the sample in this research is 40 data. The analytical method used in this research is multiple linear regression analysis. The results show that partially Good Corporate Governance and capital intensity have no effect on tax avoidance, while corporate risk has an negative effect on tax avoidance. Simultaneously Good Corporate Governance, corporate risk, and capital intensity affect tax avoidance
ҚЫЛМЫСТЫҚ БАНКРОТТЫҚ ЗАҢНАМАСЫ
Authors: РУСЯЕВ И.
Published: September 2023

В статье показаны истоки правового регулирования банкротства вообще и криминального в частности. В этих целях автор обращается к двум редакциям Русской правды, судебникам и Собор-ному уложению, которые содержали нормы о банкротстве. Анализируются виды банкротства, при этом особое внимание обращается на правовые последствия, напрямую зависящие от них, раскры-ваются льготы, предусмотренные законодательством для иностранных инвесторов, показана динами-ка изменений норм о рассматриваемом феномене.

Мақалада банкроттықтың жалпы және қылмыстық-құқықтық реттеудің бастаулары көрсетілген. Осы мақсатта автор банкроттық туралы ережелерді қамтитын «Орыс ақиқаты» екі басылымына, Заңдар кодексіне және Кеңес кодексіне жүгінеді. Банкроттықтың түрлері талданады, оларға тікелей тәуелді құқықтық салдарларға ерекше назар аударылды, шетелдік инвесторлар үшін заңнамада көзделген жеңілдіктер ашылды, қарастырылып отырған құбылыс нормаларының өзгеру динамикасы көрсетіледі.

The article shows the origins of the legal regulation of bankruptcy in general and criminal in particular. For these purposes, the author turns to two editions of the Russian Truth, the Code of Laws and the Council Code, which contained the rules on bankruptcy. The types of bankruptcy are analyzed, with particular atten-tion paid to the legal consequences that directly depend on them, the benefits provided by the legislation for foreign investors are revealed, the dynamics of changes in the norms of the phenomenon under consideration is shown.
Pengaruh Pecahan Batu Alam Andesit Sebagai Subtitusi Agregat Kasar Pada Beton Berongga
Authors: Rima Bobby Adianto , Kusuma Benny , Buarlele Luciana
Published: September 2023

Batu alam andesit adalah batu porfiritik yang terbentuk oleh letusan vulkanik dan berwarna abu-abu kehitaman dengan butiran halus. Tujuan penelitian ini adalah untuk mengetahui bagaimana pecahan batu andesit alam memengaruhi subtitusi agregat kasar. Bahan uji yang digunakan dalam eksperimen ini adalah silinder berdiameter 15cm dan tinggi 30cm, serta silinder 10 cm x 20 cm. Selama 28 hari, beton dengan kekuatan tekan rencana 20 MPa diuji untuk permeabilitas, volume pori, dan kekuatan tekan dalam penelitian ini. Hasil penelitian menunjukkan bahwa kekuatan tekannya dipengaruhi oleh perbedaan proporsi batu andesit yang ditemukan di alam. Nilai kuat tekan turun seiring dengan variasi proporsi sementara volume pori dan permeabilitas meningkat.
The Role of Deep Learning in Pharma: Revolutionizing Drug Discovery and Development.
Authors: Et al. Joti Devi
Published: September 2023

- In recent years, the pharmaceutical industry has witnessed a transformative shift in the way drugs are discovered and developed, thanks to the advent of deep learning. This paper explores the profound impact of deep learning techniques on various stages of drug discovery and development, from target identification and lead optimization to clinical trials and personalized medicine. Deep learning, a subset of artificial intelligence, has demonstrated exceptional capabilities in handling complex biological data, including genomics, proteomics, and chemical informatics. It enables the integration of vast and diverse datasets, facilitating the identification of potential drug targets with unprecedented accuracy. Moreover, deep learning models can predict the binding affinity of drug candidates to specific target proteins, expediting the lead optimization process and reducing the need for costly experimental iterations. Deep learning algorithms enhance patient stratification and biomarker discovery, ultimately leading to more successful trials with higher patient response rates. Additionally, the ability to analyze real-world patient data aids in the identification of adverse events and the development of safer drugs.

Perrsonalized medicine is another area greatly influenced by deep learning, as it allows for tailoring treatments to individual patients based on their unique genetic and clinical profiles. This promises to revolutionize patient care, optimizing therapeutic outcomes while minimizing adverse effects. Despite the remarkable advancements facilitated by deep learning, there are challenges to address, such as data privacy, interpretability of models, and regulatory considerations. This paper discusses these challenges and potential solutions. Deep learning has emerged as a powerful tool in the pharmaceutical industry, driving innovation, efficiency, and precision in drug discovery and development. Its integration into the drug development pipeline holds the promise of accelerating the delivery of safer and more effective therapies to patients worldwide, marking a significant milestone in the evolution of pharmaceutical science.
Alternatif Finansman Aracı Olarak Türkiye'de Kitlesel Fonlama ve Ekonomik Büyüme: Başarı Kriterleri ve Öneriler
Authors: ORTAARABACI Büşra , ÖZEL Bilal
Published: September 2023

Kitle fonlamanın artan piyasa hacmi bu alanda yeni bilimsel çalışmaların gerekliliğini gözler önüne sermektedir. Literatürde yer alan mevcut çalışmalar incelendiğinde; Türkiye’nin kitle fonlamada geçmiş ve günümüzdeki durumunu ortaya koyularak mevcut durumun iyileştirilmesi için alınabilecek önlemler hakkında politika önerilerinin ağırlıklı olarak yer aldığı görülmektedir. Kitle fonlama ile desteklenen proje ve ürün kampanyaları başta istihdam üzerinde yaratacağı olumlu etki ile birlikte sermaye ve yeni yatırımların ülkeye gelmesi gibi yaratacağı pozitif etkiler ile ekonomik büyümeyi de destekleyeceği düşünülmektedir. Yapılan bu çalışmada Türkiye açısından kitle fonlama platformları için düzenlemelerin çok yeni olması ve aktif olarak faaliyette bulunan platformlarda kampanya sahibi ve kampanyayı finanse edecek yatırımcıların bilgi eksikliği ile kitle fonlama sürecinde belirsizlik altında oldukları tespit edilmiştir. Sonuç olarak başarı oranlarının artırılabilmesi açısından gerekli hukuki ve teknolojik altyapının geliştirilmesi, kampanyalar hakkında fon sağlayanların eksiksiz bilgilendirilmesi ve girişimcilerin gerekli eğitimleri almasının gerekliliği gibi bazı önerilerde bulunulmuştur.
Numerical simulations of aerofoil tonal noise reduction by roughness elements
Authors: Yuan Zhenyang
Published: September 2023

In a combined experimental and numerical effort we investigate aerofoil tonal noise generation and reduction. The means of noise control are streak generators in form of cylindrical roughness elements. These elements are placed periodically along the span of aerofoil at the mid chord streamwise position. Experiments are performed for a wide range of Reynolds number and angle of attack. In the present work we concentrate on our numerical investigations. We have performed wall-resolved LES for a given angle of attack of 0 degree and Mach 0.3. Two Reynolds numbers 0.8 × 105 and 1.0 × 105 have been investigated. Through Fourier decomposition and POD analysis of streamwise stations velocity data, dominating structures have been identified. Further, the coupling between structures generated by surface roughness and instability modes (Kelvin-Helmholtz) of shear layer has been identified.
Pemanfaatan Ekosistem Digital Pada Platform E-Commerce Dalam Meningkatkan Pemasaran Dan Penjualan Produk UMKM
Authors: Zhukhruffa Syayu
Published: September 2023

Abstrak

Perkembangan teknologi informasi mengakibatkan kemunculan berbagai kanal digital. Hal ini menjadi dorongan kuat bagi para pemilik UMKM untuk beradaptasi dan bertransformasi ke arah digital. Ekosistem Digital menjadi sebuah isu penting yang terus disampaikan, baik oleh Pemerintah maupun pihak swasta yang menginisiasi Ekosistem tersebut. Menjadi bagian dari Ekosistem Digital dianggap sebagai langkah tepat bagi pemilik UMKM untuk memperluas pasar dan meningkatkan penjualan karena internet mampu melenyapkan batas geografis dan waktu serta membuka kesempatan kolaborasi. Namun di sisi lain, keterbatasan pengetahuan dan kepercayaan atas Ekosistem ini masih menjadi hambatan bagi para pelaku UMKM untuk bergabung ke dalam Ekosistem Digital yang dalam penelitian ini berfokus pada Ekosistem E-Commerce. Penelitian ini dilakukan dengan menggunakan metode kulitatif konten analisis yang dilakukan melalui tinjauan literatur dan kemudian akan disertakan juga studi kasus untuk menghasilkan pemahaman yang lebih baik. Hasil penelitian ini menunjukan bahwa pelaku UMKM perlu memahami perannya di dalam Ekosistem Digital E-Commerce, berkemampuan untuk membuat strategi digital, dan dapat mengadopsi sistem dalam Ekosistem untuk dapat meningkatkan pemasaran dan penjualan produk UMKMnya.

Abstract

The advent of information technology has led to the emergence of various digital channels, compelling small and medium enterprise (SME) owners to adapt and transform towards a digital landscape. The Digital Ecosystem has become an essential issue emphasized by both the government and private entities initiating such ecosystems. Being part of the Digital Ecosystem is considered a viable step for SME owners to expand their markets and enhance sales, as the internet has the ability to transcend geographical and temporal boundaries, while also offering collaboration opportunities. However, limited knowledge and trust regarding this Ecosystem still pose challenges for SME actors to join the Digital Ecosystem, which, in this study, specifically focuses on the E-Commerce Ecosystem. This research employs qualitative content analysis, integrating a literature review with a case study, to gain a comprehensive understanding. The findings indicate that SME actors need to comprehend their role within the Digital E-Commerce Ecosystem, possess the capacity to devise digital strategies, and successfully adopt the systems within the Ecosystem to effectively enhance marketing and sales of their products.
“Relationship can talk” - Relationship quality and its applications to STARBUCKS
Authors: Wen-Jung Chang Wen-Jung Chang , Wen-Jung Chang Kuan-Yu Yueh , Kuan-Yu Yueh Da-Chian Hu , Da-Chian Hu Hui-Ju Chen
Published: September 2023

In Taiwan, Western food has replaced Chinese cuisine, and coffee consumption is rising. Previous studies have suggested that Experiential Marketing (EM) can improve Customer Satisfaction (CS), Brand Loyalty (BL) and trust (TRT), while Brand Image (BI) impacts a brand’s perception. Furthermore, Relationship Quality (RQ) has three key dimensions: commitment (COMMIT), TRT and CS. Starbucks, a major brand in Taiwan, was chosen for the relationship marketing study. Using Structural Equation Modeling (SEM) on 294 valid respondents, this study examines six hypotheses as well as the moderating effect of EM. The results showed three mediating effects centered on CS, and EM moderated the pathway between TRT-CS and CS-COMMIT.

 
Estudos da fauna flebotomínica (Diptera: Psychodidae: Phlebotominae) e infecção natural por Leishmania infantum em municípios da região noroeste do estado de São Paulo, Brasil
Authors: Silva Vanessa Gusmon da , Taniguchi Helena Hilomi , Richini-Pereira Virgínia Bodelão , Nóbrega Diego Borin , Elias Carlos Roberto , Tolezano José Eduardo
Published: September 2023

A expansão geográfica e o crescente aumento dos casos de leishmaniose visceral na região noroeste do estado de São Paulo despertaram o interesse em desenvolver estudo para identificar a fauna flebotomínica e avaliar sua infecção natural por Leishmania infantum nos municípios de Fernandópolis, Santa Fé do Sul e Votuporanga. Foram realizados inquéritos entomológicos com a utilização de armadilhas luminosas do tipo CDC, instaladas em diferentes ecótopos peridomiciliares, durante o período de agosto de 2013 a novembro de 2014. A detecção de DNA de L. infantum em flebotomíneos foi realizada por meio da Reação em Cadeia da Polimerase (PCR). Foram coletados 507 flebotomíneos, sendo 116 fêmeas (22,9 %) e 391 machos (77,1 %), representados por sete espécies, com predomínio de Lutzomyia longipalpis, com 461 exemplares (90,9 %). As análises moleculares revelaram DNA de L. infantum em um exemplar de L. longipalpis capturado em Fernandópolis. Estes resultados confirmam a presença desta espécie nos municípios pesquisados. E o encontro de pelo menos um exemplar, naturalmente infectado, em Fernandópolis evidencia a necessidade de realizar ações de controle direcionadas aos vetores neste município, com o intuito de conter sua dispersão e prevenir a ocorrência de casos humanos de leishmaniose visceral.
Adaptação do Ecomapa proposto no Modelo Calgary para avaliação socioambiental de parasitoses intestinais em crianças de creches filantrópicas
Authors: Zagui Guilherme Sgobbi , Fregonesi Brisa Maria , Silva Thaís Vilela , Machado Carolina Sampaio , Machado Gabriel Pinheiro , Julião Fabiana Cristina , Tonani Karina Aparecida de Abreu , Segura-Muñoz Susana Inês
Published: September 2023

Os objetivos do estudo foram avaliar a frequência de enteroparasitos em crianças de creches filantrópicas e adaptar um diagrama de Ecomapa para avaliar as condições socioambientais envolvidas. Um total de 151 amostras de fezes, coletadas de 66 crianças de dois a seis anos de idade foram analisadas por meio de técnicas de Hoffman, Pons e Janer (HPJ), e de Faust e colaboradores. Um questionário estruturado foi aplicado aos responsáveis pelas crianças, e um Ecomapa foi adaptado para avaliar as interações entre as crianças parasitadas e os condicionantes socioambientais. Enteroparasitos patogênicos (Ascaris lumbricoides, Balantidium coli, Giardia lamblia e Strongyloides stercoralis) e não patogênicos (Chilomastix mesnili, Endolimax nana, Entamoeba coli e Iodamoeba butschilii) foram identificados, acometendo 37,9 % das crianças. Com o Ecomapa observaram-se fortes correlações dos parâmetros avaliados (renda familiar, higiene alimentar e pessoal, escolaridade dos responsáveis, contato com animais domésticos e interpessoal) com as crianças parasitadas. O parasito Giardia lamblia foi o de maior frequência e a adaptação do Ecomapa permitiu efetuar a avaliação dos principais condicionantes envolvidos. Diante do exposto é necessário implementar o programa de educação em saúde no ambiente escolar que estimulem os hábitos de higiene alimentar e pessoal, como atividades de prevenção e controle de parasitos.
Desempenho da cultura líquida MGIT após implementação em uma rede de laboratórios públicos do estado de São Paulo
Authors: Pedro Heloisa da Silveira Paro , Coelho Andrea Gobetti Vieira , Nardi Susilene Maria Tonelli , Vilela Gleize , Silva Jaqueline Otero , Nascimento Ana Carolina Chiou , Galle Leonilda Chiare , Aily Dalva Cristina Girello , Ferro e Silva Regina Ruivo , Shikawa Maria de Lourdes Matsuura , Leite Andrea Resende , Suaiden Mara Aparecida Garnica , Ferrazoli Lucilaine
Published: September 2023

A OMS, em 2007, recomendou a implementação da cultura líquida para o diagnóstico da tuberculose (TB) e teste de sensibilidade para países de baixa e média renda. Neste estudo foi avaliado o desempenho da cultura líquida MGIT em condição de rotina após dois anos de implantação em uma rede de laboratórios públicos. Foi efetuada análise retrospectiva de dados da cultura líquida, realizadas em dez laboratórios regionais do Instituto Adolfo Lutz, de janeiro a março de 2010. Foram incluídas amostras submetidas a baciloscopia, cultura líquida MGIT automatizada ou manual e identificação presuntiva do complexo Mycobacterium tuberculosis (CMTB). Foram detectadas 1.159 culturas positivas. Destas, 113 (9,7%) contaminaram, e 1.046 foram analisadas, sendo 850 (81,3%) CMTB, 116 (11,1%) micobactérias não tuberculosas e 6 (0,6%) Nocardia sp. A taxa de contaminação foi de 2,2% e o acréscimo da cultura para o diagnóstico da TB foi de 29,9%. A média do tempo de detecção da cultura foi de 14,7 dias (DP+/- 11,7 dias). A acurácia da identificação presuntiva foi de 91,3%. A cultura líquida MGIT demonstrou ser excelente alternativa para efetuar diagnóstico da TB e das micobacterioses, em razão da rapidez possibilitando uma intervenção rápida e eficaz no tratamento.
Antifungal activity of geraniol and citronellol against food-relevant dematiaceous fungi Cladosporium spp
Authors: Santos Aldeir Sabino dos , Silva Gezaíldo Santos , Silva Kaltz Victor Souza , Lima Maria Islaine de Oliveira , Arrua Juliana Moura Mendes , Lima Edeltrudes de Oliveira , Pereira Fillipe de Oliveira
Published: September 2023

Cladosporium spp. is a group of dematiaceous food-relevant fungi which are well dispersed in the environment causing food spoilage and poisoning. Considering the importance of fungal contamination, natural drugs to control their growth have become important. Thus, the aim of this study was to evaluate the inhibitory effects of two monoterpenoids, (geraniol and citronellol), against strains of Cladosporium carrioni, C. cladosporioides, and C. oxysporum. Methods: The Minimum Inhibitory Concentration (MIC) and Minimum Fungicide Concentration (MFC) of the drugs were determined by microdilution. The effects of test drugs on mycelial dry weight, conidia germination, and conidiogenesis of Cladosporium spp. were also investigated using a hemacytometer. Respective MIC and MFC values of citronellol varied from 256 to 512 µg/mL, and from 256 to 2048 µg/mL. The MIC and MFC of geraniol varied similarly to citronellol. Conidia germination, mycelial dry weight, and conidiogenesis of Cladosporium spp. were reduced by the test-drugs at 1/2MIC, MIC and 2xMIC (p< 0.05). These measurable cell events are essential for fungal infection and development in foods. The action of citronellol and geraniol against Cladosporium spp. suggest that the drugs may serve as effective agents for controlling fungal contamination and growth in foods.
Atividade in vitro do extrato etanólico de própolis e do digluconato de clorexidina sobre as espécies de Candida isoladas da mucosa bucal de pacientes internados em Unidade de Terapia Intensiva (UTI)
Authors: Makabe Maria Luisa , Santos Patricia de Souza , Pires Maria de Fátima Costa
Published: September 2023

Avaliou-se a atividade dos extratos de própolis e digluconato de clorexidina em Candida sp isoladas da mucosa bucal de pacientes em UTI. Foram determinadas as concentrações fungicidas mínimas (CFM) e comparadas, nas doses sub-inibitórias, à produção de exoenzimas proteinase e fosfolipase e formação de franjas. Em 72 isolados foram avaliadas a atividade antifúngica pela técnica de microdiluição em série, na “base 2”, a produção das exoenzimas proteinase e fosfolipase, e a formação de franjas, antes e após a exposição às própolis e clorexidina. Dos 72 isolados, 53 eram C. albicans, 11 C. tropicalis, quatro C. guilhermondii e quatro sugestivas de C. dubliniensis. CFM 90% do extrato de própolis foi de 5% para C. albicans, 20% C. tropicalis, 0,625% C. guilhermondii e 0,312% sugestivas de C. dubliniensis. CFM 90% da clorexidina foi de 0,0018% para C. albicans, 0,012% C. tropicalis, de 0,0018% C. guilhermondii e de 0,00375% sugestivas de C. dubliniensis. Ocorreu inibição das exoenzimas e franjas, em ambos os produtos. Apesar da inibição da clorexidina ser menor que a da própolis, seu uso diário não causa efeitos colaterais indesejáveis como manchas nos dentes e na língua, perda do paladar e sensação de queimação na mucosa bucal.
Análise comparativa entre os diferentes protocolos utilizados para o diagnóstico da leishmaniose visceral canina
Authors: Bertollo Denise Maria Bussoni , Tolezano Jose Eduardo
Published: September 2023

Foi realizada análise comparativa entre os diferentes protocolos utilizados no diagnóstico da leishmaniose visceral canina, em inquéritos soroepidemiológicos, na região de São José do Rio Preto, no período de 2008 a 2012. Para cada protocolo avaliou-se o total de exames processados, o tempo médio para examinar as amostras coletadas nos diferentes períodos e a análise de concordância bruta. Foram utilizados quatro protocolos: diagnóstico apenas pela reação de imunofluorescência indireta (RIFI) em 12.871 (28,4%) cães, por ensaio imunoenzimático (EIE) e RIFI em 632 (1,4%); 22.387 (49,4%) por EIE/RIFI, e 9.453 (20,8%) pelo teste rápido (TR) Dual Path Platform (DPP®)/EIE. Nos dois primeiros grupos, as análises foram no eluato de sangue coletado em papel de filtro, e nos dois últimos no soro sanguíneo. O protocolo TR-DPP®/EIE demandou menor tempo (dias) desde a execução até a liberação dos resultados, em comparação aos demais. Na avaliação das taxas de concordância bruta, o TR-DPP®/EIE apresentou melhor desempenho (58,5%). Apesar de, o atual protocolo TR-DPP®/EIE tenha contribuído para diminuir a discordância entre os resultados obtidos nos EIE/RIFI, o EIE confirma menos de 60% dos TR-DPP® reagentes, o que indica a necessidade de buscar novas alternativas para efetuar o diagnóstico em cães.
Avaliação da qualidade de pepinos em conserva
Authors: Santana Grez Roberta Oliveira , Machado Taiana Ferreira , Ribeiro Paula Ferreira de Araújo , Tiecher Aline
Published: September 2023

O trabalho teve como objetivo avaliar as características físicas, as físico-químicas e a rotulagem de 11 marcas de pepinos em conserva comercializados no município de Itaqui, RS. Foram realizadas a contagem do número de pepinos nos recipientes, a determinação do diâmetro e do comprimento dos pepinos, peso bruto, peso líquido, peso drenado, espaço livre, vácuo, pH, acidez total titulável e cloretos. Os rótulos das amostras de pepinos em conserva avaliados obedeceram às normas de rotulagem geral de acordo com a legislação. Os valores de peso líquido e drenado foram superiores aos especificados pelos fabricantes. O espaço livre no frasco continente variou de 0,83 a 2,23 cm e o vácuo apresentou valores entre 2,67 e 8,33 pol. Hg. A acidez total titulável apresentou valores entre 0,48 e 0,92 g de ácido acético/100 g. O pH em todas as amostras foi menor do que 4,5. Os teores de cloretos variaram de 1,70 a 3,47 g de cloreto de sódio/100 g. Pode-se afirmar que os pepinos em conserva avaliados são seguros, pois apresentaram pH menor que 4,5. No entanto, as marcas comercializadas não apresentaram padrão para as demais variáveis, pois foram encontradas diferenças nesses parâmetros avaliados.
O papel das nucleases no laboratório de biologia molecular: vilãs ou aliadas?
Authors: Castrignano Silvana Beres
Published: September 2023

Em laboratório de biologia molecular existem normas para prevenir que nucleases destruam os ácidos nucleicos em análise. Rígida adesão a estas normas é primordial, principalmente em laboratórios de análises clínicas e ao se lidar com amostras com número restrito de cópias do genoma-alvo. Em contraposição, diversas nucleases têm tido importância fundamental, por exemplo, na identificação do ácido nucleico de vírus, investigação de RNA mensageiro, purificação de vírus em abordagem metagenômica, edição de genomas com o sistema CRISPR/Cas e descoberta de enzimas. O conhecimento de como nucleases podem ser tanto vilãs quanto aliadas é essencial na formação de todos que trabalham no campo de biologia molecular.
Diversidade clínica e tratamento da leishmaniose visceral
Authors: Lindoso José Angelo Lauletta
Published: September 2023

A leishmaniose visceral (LV) é causada por protozoários do gênero Leishmania, sendo as duas principais espécies: Leismania (Leishmania) donovani e Leishmania (Leishmania) infantum, as quais tem ocorrência geográfica diversa e estão relacionadas com diversidade de manifestações clinicas e de resposta terapêutica. Notadamente, a LV que ocorre, principalmente, na Índia Sudão, Sudão do Sul, Bangladesh e Etiópia é causada pela espécie L. donovani, enquanto nas Américas e em algumas regiões da África e Europa, a espécie causadora é a L. infantum. A LV causada pela L. (L.) donovani tem um espectro clínico variando de comprometimento visceral à lesão cutânea que ocorre após um episódio de LV, que é a leishmaniose dérmica pós-kalazar (PKDL), manifestações esta que não é muito frequente na LV causada pela L. infantum. Ademais, a resposta terapêutica é divergente entre essas espécies, visto que na LV causada por L. donovani há pobre resposta ao antimonial pentavalente, configurando um padrão de resistência elevado, enquanto que na LV causada pela L. infantum essa informação não é muito clara. Neste artigo abordamos a diversidade clínica e a resposta terapêutica da LV causada principalmente por L. infantum, que é de ocorrência nas Américas.
Yesus Kristus Sang Gembala Penyembuh: Kristologi dalam Konteks Safeguarding terhadap Anak
Authors: Adi Nugraha Antonius Bagas Prasetya
Published: September 2023

This article aims to inspire readers' perspectives and help the Indonesian Catholic Church act appropriately and wisely when facing cases of sexual violence and abuse. The method used in this article is Theology in Creation, which is used to deepen the understanding of Christ as a healing shepherd who cares and fights for justice. The systematics of this article begins with the introduction of the problem, followed by a discussion of cases of sexual abuse that occurred in the history of the Catholic Church. Then, the article discusses power in Michel Foucault's theory and its challenges for political sociology. Next, the article highlights the importance of building a safe culture within the Church and protecting children from abuse. The novelty of this article lies in the Theology in Creation approach used to deepen the understanding of Christ as the healing shepherd. The article also invites the Indonesian Catholic Church to become more concerned and responsive to cases of sexual violence and abuse and to implement effective protection protocols.
Türkiye’de Öğretim Üyelerinin Bilimsel Çalışma Yapma Motivasyonları, Yetersizlikler ve Yetkinlik Sorunları: Bir Saha Araştırması
Authors: KAYA Ahmet , BOSTAN Sedat , KAYA Yasemin
Published: September 2023

Akademisyenlerin temel sorumluluğundan biri bilimsel çalışmalar yaparak bilgi ve teknoloji üretimine kaynaklık etmektir. Bu sorumluluğu yerine getirirken karşılaştıkları zorluklar akademisyenler arasında sık sık tartışılmakta ve zaman zaman kamuoyuna yansımaktadır. Bu çalışmanın amacı akademisyenlerin bilimsel çalışma süreçlerinde ve bilimsel çalışmalara destek bulmakta yaşadıkları zorlukları kendi görüşleri üzerinden belirlemektir. Çalışmada veri toplama aracı olarak araştırmacılar tarafından geliştirilen “Öğretim Üyelerinin Akademik Üretkenlik Ölçeği” kullanılmıştır. Araştırma online anket yöntemiyle Türkiye evreninde üniversitelerde görev yapan öğretim üyeleri üzerinde gerçekleştirilmiştir. Verilerin analizinde tanımlayıcı istatistiksel analizler, önemlilik testleri, korelasyon analizinden yararlanılmıştır. Verilerin analizi %95 güven aralığında gerçekleştirilmiştir. Çalışmaya 626 öğretim üyesi katılmıştır. Katılımcıların %44,4’ü (n=278) doktor öğretim üyesi, %28,3’ü (n=177) doçent, %27,3’ü (n=1741) profesördü. Ülkemizde görev yapmakta olan öğretim üyeleri akademik çalışma yapmaya istekli olmalarına rağmen bilimsel çalışma yapmak için; zaman bulmakta zorlandıklarını, alt yapı imkânların yetersiz olduğunu ve mali destek bulmakta zorlandıklarını ifade etmişlerdir. Özellikle yabancı dilde makale yazmakta ve akademik gelişimde zorluklar yaşadıkları tespit edilmiştir. Bilimsel araştırmalar için etik kurul süreçlerinin ve kurumsal izin süreçlerinin bezdirici, geciktirici ve engelleyici olduğunu belirtmişlerdir.
FORMATION FEATURES OF THE MECHANISM OF INTEGRATIVE INTERACTION OF ROSTOV REGION AND NEW REGIONS OF THE RUSSIAN FEDERATION
Authors: Скибин С.А.
Published: September 2023

Статья посвящена анализу процессов межрегиональной интеграции, затрагивающих Ростовскую область, Донецкую и Луганскую Народную Республики. В данном контексте рассматривается генезис и развитие идеи о формировании интегративного объединения данных регионов. На основе оценки результатов процедуры когнитивного моделирования делается вывод о потенциальной эффективности реализации подобного подхода при условии стабилизации военно-политической ситуации в данном макрорегионе.

The genesis and development of the idea of integrative regions’ unite are considered. Interregional integration processes concerning Rostov, Donetsk and Lugansk National Republic are analyzed. On the basis of cognitive modeling, the conclusion has been made about potential effectiveness of the implementation of such a method under the condition of stabilization of the military and political situation in that micro-region.
THE PRIORITIES SYSTEM OF REGIONAL SOCIAL AND ECONOMICAL DEVELOPMENT IN DIFFERENT CONDITIONS
Authors: Шомахова Р.А.
Published: September 2023

В статье рассматриваются сущностное содержание приоритетов регионального социально-экономического развития и особенности практической деятельности по их формированию и реализации. Подчеркивается важность адекватного определения приоритетов, основанного на анализе текущих и потенциальных тенденций данного развития. Предлагается использование сценарного подхода, предполагающего неоднородность систем приоритетов, которые наиболее актуальны при движении региона в рамках определенного тренда своего развития. Практическая апробация представленного подхода производится на примере формирования системы приоритетов регионального развития Кабардино-Балкарской Республики.

The content of priorities of regional social and economic development as well as the formation and implementation activities are considered. The priorities are based on the analysis present-day tendencies. The most relevant scenario approach which assumes heterogeneity of priority systems for the regions’ development is suggested. Practical testing of the method is being done on the example of the Kabardino-Balkaria Republic development.
Creation of the Other
Authors: Kácsor Lóránt
Published: September 2023

Review of Derek Attridge, The Singularity of Literature (London: Routledge, 2004)
From Custom to Freedom, and Back Again
Authors: Csordás Dávid
Published: September 2023

Review of Zsolt Almási, The Problematics of Custom as Exemplified in Key Texts of the Late English Renaissance, with an Introduction by Péter Dávidházi (Lewiston, Queenston, Lampeter: The Edwin Mellen Press, 2004)
Variación del porcentaje de grasa corporal y la masa libre de grasa en mujeres con sobrepeso u obesidad por medio del uso de bioimpedancia eléctrica: estudio transversal
Authors: Payan Cobo Jaime A , Tabares Gallego Alexa J , Gómez Gómez Milton C , Abreu Lomba Alin , Hernández Carrillo Mauricio
Published: September 2023

Contexto: la Organización Mundial de la Salud define obesidad como “una acumulación anormal o excesiva de grasa que puede ser perjudicial para la salud”, mientras que la definición del Consenso Español de Obesidad del 2016 es “cuando el porcentaje de masa grasa es mayor al 33% en mujeres”. Por su parte, la bioimpedancia eléctrica (BIA) cuantifica la masa grasa a partir de la masa libre de grasa, por lo que sirve como herramienta de estudio, clasificación y diagnóstico de la obesidad, sin las limitaciones que posee el índice de masa corporal (IMC).
Objetivo: describir la composición corporal en mujeres por medio de BIA, principalmente el porcentaje de grasa corporal (PGC) y el índice de masa libre de grasa (IMLG), y hacer una correlación entre la clasificación de sobrepeso y obesidad según el IMC, con el PGC calculado por BIA.
Metodología: estudio transversal y retrospectivo en una clínica de alta complejidad, el cual incluyó a mujeres entre los 18 y los 60 años, valoradas en la consulta de control de peso de Endocrinología evaluadas por BIA. Se realizó análisis descriptivo y de correlación entre IMC, PGC e IMLG a través de grupos de edad, donde con estadística no paramétrica se establecieron posibles diferencias entre los estratos de edad y se estableció una diferencia estadística con un p < 0,05.
Resultados: se evaluó a 323 mujeres con una edad media de 36,2 (± SD 9,57) años, peso con media de 73,35 kg (± SD 73,351), IMC media de 28,825 (± SD 4,69), PGC media 40,98?% (± SD 6,12), donde la mayoría de las pacientes se encontraban en el grupo de los 29 a los 39 años (42,1?%), 62 mujeres (19,2?%) tenían un IMC normal, en el grupo de sobrepeso por IMC se encontraron 158 mujeres (48,9 %), 103 mujeres (31,8?%) se encontraban en algún grado de obesidad, 62 tenían sobrepeso por PGC (19,19?%) y 261 tenían obesidad por PGC (80,80?%). Además, el IMC era mayor en el grupo de 29 a 39 años y el IMLG fue mayor en el grupo de 29 a 39 años con niveles de índice importante.
Conclusiones: aunque el uso del IMC para la clasificación de la obesidad es el parámetro que en la actualidad más se usa, tanto en el campo clínico como en el investigativo, podemos ver cómo este podría no ser la herramienta más acertada para dicha evaluación y se debería introducir el uso de PGC por métodos como la BIA para su clasificación.
Prolactinoma asociada a hiperaldosteronismo primario: ¿existe una relación entre ambas entidades?
Authors: Fragozo-Ramos María Carolina , Gómez-Galvis Laura V. , Gómez-Sierra Valeria , Román-González Alejandro
Published: September 2023

Introducción: los prolactinomas son el tipo más común de tumor hipofisario, donde los pacientes con prolactinomas presentan signos y síntomas de hipogonadismo y galactorrea. Por su parte, el aldosteronismo primario (AP) es una causa infradiagnosticada de hipertensión, caracterizada por una secreción autónoma de aldosterona. La concomitancia de estos dos síndromes ha sido reportada con poca frecuencia en la literatura.
Objetivo: presentar un caso de coexistencia de prolactinoma-AP con el fin de destacar la ocurrencia conjunta de ambas entidades y exponer el potencial vínculo fisiopatológico entre la hiperprolactinemia/prolactinoma y el AP.
Presentación del caso: mujer de 38 años con historia de varios años de oligomenorrea sin galactorrea. Bioquímica inicial con hiperprolactinemia y resonancia magnética de silla turca que reveló un prolactinoma. Durante el seguimiento, la paciente cursa con hipertensión arterial de difícil control, por lo que se exploró una causa secundaria que reveló un ratio aldosterona/actividad de renina plasmática de 232 ng/dl/ng/ml/h en presencia de un adenoma suprarrenal izquierdo de 10 mm, lo que confirmó el diagnóstico de hiperaldosteronismo primario.
Discusión y conclusión: la coexistencia de estos dos hallazgos es una condición raramente descrita en la literatura y se plantea la hipótesis de que las concentraciones elevadas de PRL podrían desempeñar un papel en la patogénesis del AP en pacientes que no forman parte del síndrome genético de neoplasia endocrina múltiple tipo 1 (MEN1 por sus siglas en inglés).
Open-source, multi-layer LSI design & fabrication framework for distributed IP development and education
Authors: Akita Junichi
Published: September 2023

Continuous development of Large Scale Integration (LSI) technologies based on Moore's law results in highly developed LSI technologies, as well as very high costs in design and fabrication and high design complexity. This fact prevents various users from contributing to the activities of designing LSIs, fabricating LSIs, and developing Intellectual Properties (IPs). On the other hand, the trend towards open-source has been attracting attention to overcome these problems and extend the potential of LSI technologies. The purpose of this research is to develop an open-source LSI design framework aimed at connecting various layers of LSI knowledge. Its methodology is composed of two parts. One is the development of the LSI design flow using existing open-source EDA tools and their related glue software. The other is the open-source, NDA-free PDK (process design kit) used in designing LSIs. The process of developing and constructing Large Scale Integrated (LSI) circuits within this framework is conducted and assessed. From these trials, the effect of enhancing educational effectiveness on LSI design is indicated. These trials enhanced the contributors’ interest and motivation to understand the details of computer systems and their relation to LSIs. It is also indicated that this framework is effective in enhancing rapid IP development as well as its importance as an educational aspect of open-source software.
OIL SLUDGE THERMOCHEMICAL CONVERSION: GASIFICATION AND AMMONIA SYNTHESIS CASE
Authors: Oliveira H. D. Z. S. , Santiago Y. C. , González A. M. , Pinheiro I. F. , Barbosa K. P. , Sphaier L. A.
Published: September 2023

This work aims to evaluate the gasification of oily sludge (OS) and the potential use of produced gas as feedstock for ammonia production. For this purpose, a computational gasification model was developed and validated in Aspen Hysys® v. 11.0 software to evaluate the influence of air/steam mixtures as gasification agents on the studied parameters. The Lower Heating Value (LHV) of the producer gas varied between 5 and 10 MJ/m3 for equivalence ratios greater than 0.3. The molar concentration of H2 increased to 24.9% at 1380°C and decreased to 21.5% at 1700°C. Finally, the producer gas was used to synthesize ammonia, where a conversion of more than 90% was obtained at a pressure of 100 bar and a temperature of 450°C. The results showed that oil sludge gasification could be a viable alternative to efficiently converting refinery waste into valuable products.
EMULSIONS IN OFFSHORE PETROLEUM PRODUCTION: STABILITY AND FLOW ASSURANCE
Authors: Charin R. M. , Nele M.
Published: September 2023

Emulsions represent a relevant concern in offshore petroleum production. Besides the topside oil-water separation, other topics related to flow assurance have received increasing attention from industry and academy. This paper reviews petroleum emulsions and their aspects that impact offshore petroleum production. Topics discussed in this review include emulsion stability, emulsion samples, and flow assurance related topics like pressure-drop, wax, and hydrates. The knowledge around petroleum emulsions has reached a fair level in terms of stabilization and destabilization mechanisms. Nevertheless, challenges, such as understanding the emulsion formation in presence of pressurized gas and comprehending how emulsions affect the multiphase flow behavior as well as the precipitation of solids, remain.
Towards an information system to support forestry research
Authors: Saxena Vishal , Gupta Somesh , Mishra Rajeev
Published: September 2023

Information technology has emerged as an effective communication tool in reducing the knowledge gap among the researchers, involved in the forestry sector. A researcher can enhance his knowledge by using latest technology like CD-ROM, e- mail and Internet. This paper aims to analyze the existing technologies available to save the researcher’s time by giving specific search engines and exact location of Website address.