bluuebunny/crossref_metadata_2025 huggingface dataset:
Relato de caso incomum de leucemia de células pilosas de evolução aguda em paciente adulto jovem, Amazônia, Brasil
Authors: Nascimento Aline Lira do , Brito Junior Lacy Cardoso de
Published: June 2021

A Leucemia de Células Pilosas (LCP) é uma doença rara, de origem desconhecida, de curso indolente, e que se apresenta no hemograma associada a pancitopenia e linfócitos com projeções citoplasmáticas. No presente estudo apresentamos o relato de caso de um paciente de 31 anos, masculino, hipocorado, sem esplenomegalia, admitido no Hospital Municipal de Rondon do Pará, Amazônia, no dia 31.12.2018 para a realização de exames laboratoriais em função de rebaixamento do estado geral. O hemograma revelou: anemia (7.5g/dL de hemoglobina e 20% de hematócrito), plaquetopenia (28.200/mm3) e hiperleucocitose (179.000/mm3) as custas de 88% de linfócitos com projeções citoplasmáticas finas e alongadas sugestivas de células pilosas. No dia 07.01.2019 houve piora do quadro do paciente com evolução a óbito antes mesmo da confirmação diagnóstica pelo exame de imunofenotipagem que revelou tratava-se de população clonal de 68,3% de células pilosas com expressão dos antígenos: CD19, CD20, CD79b, CD23, IgM, CD200, CD38, FMC-7, CD25 e CD103. Não tendo sido possível a determinação de quais fatores foram determinantes para esse quadro.
Computed Tomography Angiography Spot Sign, Hematoma Expansion, and Functional Outcome in Spontaneous Cerebellar Intracerebral Hemorrhage
Authors: Singh Sanjula D. , Pasi Marco , Schreuder Floris H.B.M. , Morotti Andrea , Senff Jasper R. , Warren Andrew D. , McKaig Brenna N. , Schwab Kristin , Gurol M. Edip , Rosand Jonathan , Greenberg Steven M. , Viswanathan Anand , Klijn Catharina J.M. , Rinkel Gabriel J.E. , Goldstein Joshua N. , Brouwers H. Bart
Published: June 2021

Background and Purpose:

The computed tomography angiography spot sign is associated with hematoma expansion, case fatality, and poor functional outcome in spontaneous supratentorial intracerebral hemorrhage (ICH). However, no data are available on the spot sign in spontaneous cerebellar ICH.

Methods:

We investigated consecutive patients with spontaneous cerebellar ICH at 3 academic hospitals between 2002 and 2017. We determined patient characteristics, hematoma expansion (>33% or 6 mL), rate of expansion, discharge and 90-day case fatality, and functional outcome. Poor functional outcome was defined as a modified Rankin Scale score of 4 to 6. Associations were tested using univariable and multivariable logistic regression.

Results:

Three hundred fifty-eight patients presented with cerebellar ICH, of whom 181 (51%) underwent a computed tomography angiography. Of these 181 patients, 121 (67%) were treated conservatively of which 15 (12%) had a spot sign. Patients with a spot sign treated conservatively presented with larger hematoma volumes (median [interquartile range]: 26 [7–41] versus 6 [2–13],
P
=0.001) and higher speed of expansion (median [interquartile range]: 15 [24–3] mL/h versus 1 [5–0] mL/h,
P
=0.034). In multivariable analysis, presence of the spot sign was independently associated with death at 90 days (odds ratio, 7.6 [95% CI, 1.6–88],
P
=0.037). With respect to surgically treated patients (n=60, [33%]), 14 (23%) patients who underwent hematoma evacuation had a spot sign. In these 60 patients, patients with a spot sign were older (73.5 [9.2] versus 66.6 [15.4],
P
=0.047) and more likely to be female (71% versus 37%,
P
=0.033). In a multivariable analysis, the spot sign was independently associated with death at 90 days (odds ratio, 2.1 [95% CI, 1.1–4.3],
P
=0.033).

Conclusions:

In patients with spontaneous cerebellar ICH treated conservatively, the spot sign is associated with speed of hematoma expansion, case fatality, and poor functional outcome. In surgically treated patients, the spot sign is associated with 90-day case fatality.
A Whole-of-Society Approach to the Rohingya Refugee Crisis: Strengthening Local Protection Capacity in South and South-East Asia
Authors: Barbour Brian , Fan Lilianne , Lewa Chris
Published: June 2021

In 2020, Rohingya men, women, and children continue to embark across the Bay of Bengal and Andaman Sea, and States continue to lack safe and predictable disembarkation protocols and standards. From a protection perspective, the situation in 2020 has played out as it did in 2015 showing a lack of progress. After decades of discriminatory policies, denial of basic human rights, and targeted violence, at least 1.5 million stateless Rohingya refugees have fled Myanmar’s Rakhine State to seek refuge in the region and scattered locations around the globe, often surviving horrendous journeys by sea in the hope of disembarking with even marginally better prospects. The reception of the Rohingya in each of their places of refuge has been mixed, but it has rarely if ever been one of unqualified welcome. How do we engage with challenges that seem so intractable? The academic literature looking at refugee protection in the Asian region has largely dealt with its absence or inadequacy. Yet if we look more closely at any specific context in Asia, we can see that States may have laws, policies, or practices that can be utilised to recognise or respond to protection needs; international institutions like the United Nations High Commissioner for Refugees (unhcr) are often recognised and permitted to conduct protection activities; civil society actors in every jurisdiction have developed substantial capacity for operationalising protection in practice; and refugees themselves are coping and contributing to their own protection in every case. It is at the national and local levels where protection capacity must be built towards implementation of a ‘whole-of-society’ approach.
Towards an asean Model of ‘Responsibility-Sharing’ for Refugees and Asylum-Seekers
Authors: McMillan Kate , Petcharamesree Sriprapha
Published: June 2021

The Andaman Sea crisis of 2015 focused global attention on asean’s response to mass refugee flows and generated calls for greater regional cooperation to protect the rights and safety of forced migrants. Such calls draw from the concept of ‘responsibility-sharing’; a concept that has long underpinned the international refugee regime. Scholars have responded to this challenge by identifying a range of ways in which asean countries might benefit from sharing responsibility for the refugees and asylum-seekers in their region. Based on interviews with 40 key asean-based actors working on migration and refugee issues across the governmental and non-governmental sectors, this article seeks to understand how the concept of responsibility-sharing for refugee protection is understood in four Southeast Asian countries: Thailand, Malaysia, Indonesia and Singapore. While it finds common agreement among the interviewees that the Andaman Sea crisis was a humanitarian disaster and that existing approaches to refugee issues in the region are ineffective, it also finds little to suggest that a regional approach to refugee issues is likely to develop in the short-to-medium term. On the other hand, interviewees identified a wide range of mechanisms through which bilateral, multilateral and global initiatives might assist the region to deal with refugee and asylum issues. Linking refugee issues with other issues that concern asean Member States and incremental progress towards embedding regional human rights norms via asean human rights institutions are identified as the most fruitful pathways towards regional cooperation to protect refugee rights and safety.
Two new species of Neotropical Leptomorphus Curtis (Diptera: Mycetophilidae)
Authors: FITZGERALD SCOTT J.
Published: June 2021

Two new species of Leptomorphus Curtis, L. guatemalensis sp. n. and L. juxtafurcatus sp. n., are described from Guatemala, figured, and compared with congeners. The new species belong to the clade including the “furcatus” and “walkeri” species-groups as defined by Borkent & Wheeler (2012). L. guatemalensis sp. n. can be recognized by the gonocoxite bulbous and crescent-shaped with the apex asetose and spatula-like, but remains without a clear sister-species. Based on the structure of the male terminalia, particularly the presence of submedian, pointed lobes on sternite nine, L. juxtafurcatus sp. n. is suggested to be the sister-species to L. furcatus Borkent from the southwestern USA and northern Mexico; these species can be distinguished by the form of the gonocoxites.
Robust worst-case scenarios from ensemble forecasts
Authors: Scher Sebastian , Jewson Stephen , Messori Gabriele
Published: June 2021

To extract the most information from an ensemble forecast, users would need to consider the possible impacts of every member in the ensemble. However, not all users have the resources to do this. Many may opt to consider only the ensemble mean and possibly some measure of spread around the mean. This provides little information about potential worst-case scenarios. We explore different methods to extract worst-case scenarios from an ensemble forecast, for a given definition of severity of impact: taking the worst member of the ensemble, calculating the mean of the N worst members, and two methods that use a statistical tool known as directional component analysis (DCA).We assess the advantages and disadvantages of the four methods in terms of whether they produce spatial worst-case scenarios that are not overly sensitive to the finite size and randomness of the ensemble or small changes in the chosen geographical domain. The methods are tested on synthetic data and on temperature forecasts from ECMWF. The mean of the N worst members is more robust than the worst member, while the DCA-based patterns are more robust than either. Furthermore, if the ensemble variability is well-described by the covariance matrix, the DCA patterns have the statistical property that they are just as severe as those from the other two methods, but more likely. We conclude that the DCA approach is a tool that could be routinely applied to extract worst-case scenarios from ensemble forecasts.
Laparoscopic-Assisted Transgastric Endoscopic Retrograde Cholangiopancreatography With Placement of a Biliary Stent to Treat Traumatic Intrahepatic Bile Duct Disruption in a Patient With Roux-en-Y Gastric Bypass
Authors: Portelli Tremont Jaclyn N. , Kratzke Ian M. , Motameni Amirreza , Nunoo Robert , Chung Ann
Published: June 2021

Hepatic injuries are common following blunt trauma and while frequently managed expectantly, biliary injury as a result of the trauma requires a high index of suspicion, a focused workup, and likely interventional treatment. A 44-year-old female with a history of Roux-en-Y gastric bypass presented after a ground level fall and was initially discharged home but represented with worsening abdominal pain and elevated liver enzymes. She was found to have a segment 5/6 biliary injury requiring laparoscopic-assisted transgastric endoscopic retrograde cholangiopancreatography with common bile duct stent placement. This case represents the difficulty of diagnosing biliary injuries following blunt trauma, and the need for advanced endoscopic interventions for treatment in patients with atypical anatomy.
Method-dependent variation in TSH and FT4 reference intervals in pregnancy: A systematic review
Authors: Okosieme Onyebuchi E , Agrawal Medha , Usman Danyal , Evans Carol
Published: June 2021

Background

Gestational TSH and FT4 reference intervals may differ according to assay method, but the extent of variation is unclear and has not been systematically evaluated. We conducted a systematic review of published studies on TSH and FT4 reference intervals in pregnancy. Our aim was to quantify method-related differences in gestation reference intervals, across four commonly used assay methods, Abbott, Beckman, Roche and Siemens.

Methods

We searched the literature for relevant studies, published between January 2000 and December 2020, in healthy pregnant women without thyroid antibodies or disease. For each study, we extracted trimester-specific reference intervals (2.5–97.5 percentiles) for TSH and FT4 as well as the manufacturer-provided reference interval for the corresponding non-pregnant population.

Results

TSH reference intervals showed a wide range of study-to-study differences with upper limits ranging from 2.33 to 8.30 mU/L. FT4 lower limits ranged from 4.40 to 13.93 pmol/L, with consistently lower reference intervals observed with the Beckman method. Differences between non-pregnant and first trimester reference intervals were highly variable, and for most studies, the TSH upper limit in the first trimester could not be predicted or extrapolated from non-pregnant values.

Conclusions

Our study confirms significant intra- and intermethod disparities in gestational thyroid hormone reference intervals. The relationship between pregnant and non-pregnant values is inconsistent and does not support the existing practice in many laboratories of extrapolating gestation references from non-pregnant values. Laboratories should invest in deriving method-specific gestation reference intervals for their population.
Perceived Affordances and Regret in Online Travel Agencies
Authors: Jo Hwirim , Chung Namho , Hlee Sunyoung , Koo Chulmo
Published: June 2021

Despite the revolutionary system of online booking, the decision-making process for booking hotels is still very stressful for customers, who face much uncertainty. The wide range of products and great volume of information result in significant cognitive overload. Therefore, online travel agencies (OTAs) try to reduce customers’ cognitive effort requirements and to induce effective decision making by triggering potential actions through perceived affordance. This study aims to explore the influence of perceived affordance on purchase decisions and postpurchase emotion in the context of OTAs. The findings show that explicit affordance and hidden affordance significantly affect impulsive buying, thus resulting in postpurchase discomfort and regret. Additionally, the outcomes of a multiple group analysis revealed a significant moderating effect of regulatory focus orientation on impulsive buying and postpurchase regret during an overall purchase process involving OTAs.
Older Adults’ Subjective Cognitive Decline Correlated with Subjective but Not Objective Sleep: A Mediator Role of Depression
Authors: Jiang Hai-Xin , Xie Xin , Xu Yang , Wang Rui , Lei Xu , Yu Jing
Published: June 2021

This study examined the relationship between older adults’ subjective versus objective sleep and subjective cognitive decline (SCD), and explored the role of depression on this association. One hundred and four community-dwelling older adults underwent a week of actigraphic sleep monitoring, and completed a series of neuropsychological screeners. Older adults’SCD score was positively correlated with subjective insomnia, but not with objective sleep parameters. Further mediation modeling revealed that older adults’depression mediated the association between subjective insomnia and SCD. Subjective sleep, rather than objective sleep, may be a more sensitive indicator for older adults’ SCD, with depression symptoms appearing to account for most of the variance. These findings extend our perspective on the relationship between sleep disruption and cognitive decline, and highlight the necessity of early targeted interventions on sleep to reduce the risk of cognitive impairment in the elderly with SCD.
Market Perceptions of Fair Value Reporting for Tangible Assets
Authors: Conaway Jenelle K. , Liang Lihong , Riedl Edward J.
Published: June 2021

This article examines equity market perceptions of fair value reporting for tangible assets. We identify six events—four designated as increasing, two as decreasing—affecting the likelihood of U.S. adoption of fair value reporting for investment property (i.e., real estate) assets, one of the largest asset classes in the world. Fair value adoption in the United States would facilitate convergence of one of the widest remaining disparities between U.S. reporting and International Financial Reporting Standards (IFRS): accounting for tangible investment property assets, where the United States (IFRS) requires depreciated historical cost (recognized or disclosed fair values). Using a sample of U.S. investment property firms, we document an average positive market reaction for movement toward fair value reporting. We further find predictable cross-sectional variation, with the market reaction increasing for firms with greater commitment to high-quality reporting, greater investor demand for fair values, higher financial risk, and staler asset values. Overall, the results are consistent with U.S. equity markets perceiving net benefits to movement toward a fair value reporting approach for this asset class.
Exacerbation of Background Nuclear Cataracts in Sprague-Dawley Rats in Embryo-Fetal Development Studies With JNJ-42165279, a Fatty Acid Amide Hydrolase Inhibitor
Authors: van Heerden Marjolein , Roosen Wendy , Lachau-Durand Sophie , Bailey Graham , Ndifor Anthony
Published: June 2021

Fetal examinations in embryo-fetal developmental (EFD) studies are based on macroscopic and dissecting microscopic evaluations, and histopathology is rarely performed other than to confirm macroscopic findings. Fetal lens examination is therefore generally limited to the presence, size, shape, and color of any abnormality. In a Sprague-Dawley rat EFD study with the fatty acid amide hydrolase (FAAH) inhibitor JNJ-42165279, an unusually high incidence of macroscopic granular foci was noted within the lens of gestation day 21 fetuses across all groups including controls, with higher incidence in the high-dose group. On histological evaluation of the lenses from fetuses with/without gross findings, primary lens fiber hypertrophy (swelling) and degeneration were observed across vehicle- and JNJ-42165279-exposed fetuses. In a follow-up study to investigate the progression or resolution of the fetal lens changes, animals exposed to suprapharmacological doses of JNJ-42165279 in utero had higher incidence of nuclear cataracts as detected via slit-lamp ophthalmic examinations on postnatal days 18 to 21 and 35 to 41. No histologic correlates for these cataracts were identified. We conclude that fetal primary lens fiber hypertrophy and nuclear cataracts at ophthalmology, are common background changes in this rat strain that are exacerbated by in utero exposure to the FAAH inhibitor JNJ-42165279.
Identifying Phenotypically Distinct Fibroblast Subsets in Type 2 Diabetes–Associated Iatrogenic Laryngotracheal Stenosis
Authors: Lina Ioan A. , Berges Alexandra , Ospino Rafael , Davis Ruth J. , Motz Kevin M. , Tsai Hsiu‐Wen , Collins Samuel , Hillel Alexander T.
Published: June 2021

Objective

Iatrogenic laryngotracheal stenosis (iLTS) is the pathologic narrowing of the glottis, subglottis, and/or trachea secondary to intubation or tracheostomy related injury. Patients with type 2 diabetes mellitus (T2DM) are more likely to develop iLTS. To date, the metabolomics and phenotypic expression of cell markers in fibroblasts derived from patients with T2DM and iLTS are largely unknown.

Study Design

Controlled in vitro cohort study.

Setting

Tertiary referral center (2017‐2020).

Methods

This in vitro study assessed samples from 6 patients with iLTS who underwent surgery at a single institution. Fibroblasts were isolated from biopsy specimens of laryngotracheal scar and normal‐appearing trachea and compared with controls obtained from the trachea of rapid autopsy specimens. Patients with iLTS were subcategorized into those with and without T2DM. Metabolic substrates were identified by mass spectrometry, and cell protein expression was measured by flow cytometry.

Results

T2DM iLTS‐scar fibroblasts had a metabolically distinct profile and clustered tightly on a Pearson correlation heat map as compared with non‐T2DM iLTS‐scar fibroblasts. Levels of itaconate were elevated in T2DM iLTS‐scar fibroblasts. Flow cytometry demonstrated that T2DM iLTS‐scar fibroblasts were associated with higher CD90 expression (Thy‐1; mean, 95%) when compared with non‐T2DM iLTS‐scar (mean, 83.6%; P =. 0109) or normal tracheal fibroblasts (mean, 81.1%; P =. 0042).

Conclusions

Scar‐derived fibroblasts from patients with T2DM and iLTS have a metabolically distinct profile. These fibroblasts are characterized by an increase in itaconate, a metabolite related to immune‐induced scar remodeling, and can be identified by elevated expression of CD90 (Thy‐1) in vitro.
Separated by a common language: How Breitbart and The New York Times produce different meanings from common words
Authors: Mor Federico , Nash Erin J , Green Fergus
Published: June 2021

We build on the work by Peled and Bonotti to illuminate the impact of linguistic relativity on democratic debate. Peled and Bonotti’s focus is on multilingual societies, and their worry is that ‘unconscious epistemic effects’ can undermine political reasoning between interlocutors who do not share the same native tongue. Our article makes two contributions. First, we argue that Peled and Bonotti’s concerns about linguistic relativity are just as relevant to monolingual discourse. We use machine learning to provide novel evidence of the linguistic discrepancies between two ideologically distant groups that speak the same language: readers of Breitbart and of The New York Times. We suggest that intralinguistic relativity can be at least as harmful to successful public deliberation and political negotiation as interlinguistic relativity. Second, we endorse the building of metalinguistic awareness to address problematic kinds of linguistic relativity and argue that the method of discourse analysis we use in this article is a good way to build that awareness.
The effect of audio description on film comprehension of individuals with visual impairment: A case study in Turkey
Authors: Zengin Temırbek uulu Zeynep , Sağın-Şimşek Çiğdem , Antonova-Ünlü Elena
Published: June 2021

The present study aimed to investigate the extent to which audio description contributes to the visually impaired individuals’ comprehension of a film by examining the visually impaired and sighted participants’ comprehension of two versions of the same film, one with and the other without supplementary audio description. The results of the study showed that the visually impaired participants were able to comprehend and narrate the events to the same extent as the sighted participants did when the film was supplemented with audio description. The qualitative analysis validated this finding and demonstrated that the visually impaired participants were able to comprehend the film to a great extent with the assistance of audio description. These findings emphasized the role of audio description assistance and its effects as an important resource in converting visual information to vocal information, which greatly aids the visually impaired individuals’ film comprehension. Also, the use of “Causal Network Model” showed that understanding the plot better could enable the audio description creators to provide better assistance for the visually impaired if they applied this model.
Epinephrine dosing interval and neurological outcome in out-of-hospital cardiac arrest
Authors: Fukuda Tatsuma , Kaneshima Hirotsugu , Matsudaira Aya , Chinen Takumi , Sekiguchi Hiroshi , Ohashi-Fukuda Naoko , Inokuchi Ryota , Kukita Ichiro
Published: June 2021

Objective:

Current guidelines for cardiopulmonary resuscitation (CPR) recommend that standard-dose epinephrine be administered every 3–5 minutes during cardiac arrest. However, there is a knowledge gap regarding the optimal epinephrine dosing interval. This study aimed to examine the association between epinephrine dosing intervals and outcomes after out-of-hospital cardiac arrest (OHCA).

Methods:

This was a nationwide population-based observational study using data from a Japanese government-led registry of OHCA, including patients who experienced OHCA in Japan from 2011 to 2017. We defined the epinephrine dosing interval as the time interval between the first epinephrine administration and return of spontaneous circulation in the prehospital setting, divided by the total number of epinephrine doses. The primary outcome was 1-month neurologically favorable survival.

Results:

A total of 10,965 patients (mean (SD) age, 75.8 (14.3) years; 59.8% male) were included. The median epinephrine dosing interval was 3.5 minutes (IQR, 2.5–4.5; mean (SD), 3.6 (1.8)). Only approximately half of the patients received epinephrine administration with a standard dosing interval, as recommended in the current CPR guidelines. After multivariable adjustment, compared with the standard dosing interval, neither shorter nor longer epinephrine dosing intervals were associated with neurologically favorable survival after OHCA (Short vs Standard: adjusted OR 0.87 [95%CI 0.66–1.15]; and Long vs Standard: adjusted OR 1.08 [95%CI 0.76–1.55]). Similar associations were observed in propensity score-matched analyses.

Conclusions:

The epinephrine dosing interval was not associated with 1-month neurologically favorable survival after OHCA. Our findings do not deny the recommended epinephrine dosing interval in the current CPR guidelines.
Third Parties Mirror the Aggression of the Antagonists: A Video-Based Analysis of Third-Party Aggression in Interpersonal Conflicts
Authors: Ejbye-Ernst Peter , Lindegaard Marie Rosenkrantz , Bernasco Wim
Published: June 2021

Third parties tend to take an active role and intervene in interpersonal conflicts in public. Previous research has shown that the level of aggression of these interventions determines how they influence the conflict. No previous study has, however, systematically investigated whether the aggression of third-party interventions is influenced by the development of the conflict situation. The objective of this study is twofold. First, the study determines the extent to which the aggression level of intervening third parties changes during the course of interpersonal conflicts. Second, the study identifies and investigates the factors that affect the aggression levels displayed by intervening third parties. We systematically observed and coded CCTV footage of 46 interpersonal conflicts in public space, recorded by surveillance cameras in Amsterdam, the Netherlands. The data included 565 intervention behaviors by 125 third parties. We recorded the levels of aggression of the individuals involved in the conflict and conducted a multinomial logistic regression analysis to investigate what influenced the aggression level of the third-party interventions. We found that the aggression levels of the preceding intervention behaviors by the third parties predict aggression levels of their subsequent interventions. This shows a consistency in third-party interventions over the course of a conflict. We also found that the aggression levels of the conflict parties that are the targets of the interventions influence the aggression levels of third-party intervention. This finding demonstrates that the development of the conflict situation influences how aggressive the third parties are. Our study emphasizes the importance of taking the interactional dynamics of interpersonal conflicts into consideration when explaining third-party behavior.
Health and Health Service Needs: Comparison of Older and Younger Women with Criminal−Legal Involvement in Three Cities
Authors: Emerson Amanda , Lipnicky Ashlyn , Comfort Megan , Lorvick Jennifer , Cropsey Karen , Smith Sharla , Ramaswamy Megha
Published: June 2021

Objectives: We profiled the health and health services needs of a sample of older adult women (age 50+) with criminal–legal system (CLS) involvement and compared them with younger women (age 18–49), also CLS-involved. Methods: Using survey data collected from January to June 2020 from adult women with CLS involvement in three US cities, we profiled and compared the older adult women with younger women on behavioral and structural risk factors, health conditions, and health services access and use. Results: One-third (157/510) were age 50+. We found significant differences ( p < .05) in health conditions and health services use: older women had more chronic conditions (e.g., hypertension and stroke) and more multimorbidity and reported more use of personalized care (e.g., private doctor, medical home, and health insurance). Discussion: Although older women with CLS involvement reported good access to health services compared with younger women, their chronic health conditions, multimorbidity, and functional declines merit attention.
The optimal control of assembly deviation for large thin-walled structures based on basic deviation patterns
Authors: Gao Chang , Yu Haidong , Yuan Ke , Lai Xinmin
Published: June 2021

The deviation vector at arbitrary location of large thin-walled structure caused by manufacturing process is different and has the characteristic of field distribution, which has great influence on the assemble quality. The deviation of each point on the part is not independent, and the final assembly deviation is difficult to be controlled. In this paper, the deviation field of large thin-walled structure is described by the linear combination of a series of basic deviation patterns. The deviation propagation model is established to quantify the contribution of basic deviation patterns between parts and assembly. A new two-step optimization method based on the adjustment of key control points of the part is proposed for the deviation control of large thin-walled structures. Firstly, the effective independent method is employed to obtain the optimal measurement points, which may characterize all basic deviation patterns of the part accurately. Then a new optimization model is developed to determine the key control points for special basic deviation pattern, which have little influence on the other basic deviation patterns. Based on the genetic optimization algorithm, the optimal key control points and the adjusted quantities for special basic deviation pattern are obtained, simultaneously. A case study on the assembly process of two cylindrical thin-walled parts with initial deviations measured by the Laser Scan Device is conducted. The basic deviation pattern with great influence on the deviation of assembly is determined firstly. The key control points and the corresponding adjusted quantities for this basic deviation pattern are calculated. The results indicate that the deviation of the assembled structure may be suppressed by the adjusted deformation of the key control points of parts. It is useful on the deviation control for the assembly process of large thin-walled structures.
A model-based design methodology for flight control systems: Global 7500 pitch control case study
Authors: Liscouët Jonathan
Published: June 2021

This article introduces an original model-based design methodology addressing a high-performance aircraft design challenge: conflicting performance requirements. The case study of the Global 7500 elevator actuation system also provides in-depth insight into the complex design process of today’s fly-by-wire flight control systems. The methodology presented here redefines the aircraft manufacturer’s involvement in the design process of the systems, implementing analysis and iteration capabilities early in system development. To this end, it introduces a novel modeling approach for analyzing loaded rate requirements by simulating closed-loop performance with a generic nonlinear second-order state filter, including the main performance limitations without requiring a preliminary design definition. In this way, it provides means to mature the system requirements and addresses requirement conflicts upfront. Then, a simulation-based preliminary sizing and performance assessment validates the candidate design concept. It also secures the preliminary design phase by implementing advanced design uncertainties and involving interfacing systems and disciplines early in the process. The redefined methodology identified directly that the problem’s root cause was a conflict between stability and control and flutter protection requirements. It also indicated that the first sizing driver is the response time required under a specific failure case. These findings lead to an optimal elevator actuator design compliant with matured performance requirements. Thus, the methodology resolved a design challenge blocking the Global 7500 aircraft development and prevented redesign occurrences later during the detailed design phase. In this way, it directly contributed to the successful development of the Global 7500 and its optimal operational performance. This methodology applies to future aircraft design challenges, and the technical insight provides valuable lessons learned for high-performance T-tail business jets.
Reasons versus causes in Arocha’s scientific realism
Authors: Lo Dico Giuseppe
Published: June 2021

Arocha’s scientific realism (2021) puts at the center of psychology the individual and their variability in behavior: the individual appears to be irreducible to what emerges from the analysis of aggregate data. According to this position, psychology’s aim is to uncover the mechanisms underlying the observable world. This entails adopting the cause-based approach of the natural sciences. Arocha’s article also refers to final causes and intentions and thus to the reason-based approach of the human sciences in contrast to that of the natural sciences. Thus, it is not clear whether the article aims to reduce the final causes to mechanical causes or supports the irreducibility of the former. Starting from these remarks, this comment will argue that the reason-based approach is preferable to the cause-based approach in order to have a scientific psychology. Adopting the reason-based approach also avoids the appeal to aggregate data by focusing upon the single case.
Out-of-Pocket Payments for Delivery Care in India: Do Households face Hardship Financing?
Authors: Yadav Jeetendra , John Denny , Menon Geetha R. , Allarakha Shaziya
Published: June 2021

Background:

Present study aims to examine the socioeconomic and demographic factors that affect health care utilization, health care expenditure and financing strategies for delivery care in India.

Methods:

The study uses data from National Family Health Survey (NFHS-4), 2015-2016. Descriptive, bivariate and multivariate regression analysis were carried out to examine health care utilization, out of pocket expenditure and financing strategies for delivery care in India. We used hardship financing as when people resort to borrowings, or sale of property/jewelry to pay for healthcare expenditure

Results:

Overall, Janani Suraksha Yojana (JSY) could cover less than 40% of the delivery care expenditure across all states. One-third of the households borrowed money or sold property/jewelry for delivery care expenditure. Highest exposure to hardship financing was observed in utilisation of private healthcare facilities for delivery. Women from the higher income quintiles are less likely to experience hardship financing as compared to women from the poorest wealth quintile.

Conclusions:

The study results will be useful for government to ensure that financing policies for delivery such as JSY are effective to provide availability and affordability of delivery healthcare in India.
Distal Tibial Reconstruction in the Management of Primary Bone Tumors in Children and Adolescents
Authors: Raciborska Anna , Bilska Katarzyna , Malesza Iwona , Rodriguez-Galindo Carlos , Pachuta Bartosz
Published: June 2021

Background:

Distal tibial primary bone tumors are rare, and options for limb salvage surgery are limited and challenging. Importantly, local control has shown to be crucial and necessary for cure, and radical surgery is one of the most important components of therapy for some bone sarcomas. We investigated the feasibility and functional and oncological outcomes of distal tibial reconstruction using endoprosthesis in children with malignant bone tumors.

Methods:

Fourteen patients (median age 13.6 years) with primary bone tumors (4 Ewing sarcoma [ES], 10 osteosarcoma) of the distal tibiae were treated during 2013-2019. All patients had reconstruction using a modular (13 patients) or expandable custom-made titanium bone replacement system (1 patient). All patients received chemotherapy before and after surgery.

Results:

Twelve patients (85.7%) are alive with a median follow-up 20 months from diagnosis. Five-year estimates of event-free survival and overall survival were 60.6% and 76.4%, respectively. Three patients had postoperative complications requiring second surgery. Maximum dorsiflexion and plantar flexion of the foot were 20 degrees (range 0-20 degrees) and 20 degrees (range 5-20 degrees), respectively.

Conclusion:

For select distal tibial sarcomas, after neoadjuvant chemotherapy pretreatment and radical resection, reconstruction using an endoprosthesis as a radical surgery provides an option was associated with a low rate of short-term local complications and relatively good early function.

Level of Evidence:

Level IV, therapeutic study.
Research on Chinese Contemporary Social Life
Authors: Zhang Letian
Published: June 2021

In this article, Zhang first recounts his personal journey from being a “sent-down” youth to a returned researcher endeavoring to understand the logic and social fabric of the Chinese countryside during the collective era. He then demonstrates the interplay between internal and external forces that shaped and ultimately doomed the commune system. Finally, Zhang describes how he unexpectedly stumbled upon a large volume of personal letters soon after he founded the Center in 2011. Since then, with deliberate and unwavering effort, the Center has gathered a sizable collection of primary materials that provide invaluable insights into social life in China.1
Theorizing Knowledge With Pláticas: Moving Toward Transformative Qualitative Inquiries
Authors: Flores Carmona Judith , Hamzeh Manal , Delgado Bernal Dolores , Hassan Zareer Ifham
Published: June 2021

In this article, we engaged in pláticas to write about the methodology of pláticas. We show the use of this method by theorizing the pláticas. Our pláticas helped us reveal how we have experienced epistemicide and apartheid of knowledge blocked by epistemological racism in academia. We emphasized how the marginalization and invalidation in academia of this method happens and continues to happen especially in the social sciences. We demonstrate how this method has not been absent, but rather it has not been legitimized in academia. We also show how our refusal to employ dominant epistemologies allows us to move toward transformative qualitative inquiries.
The use of Ologen Collagen Matrix implants to treat ocular hypotony developing after trabeculectomy: A case series
Authors: Russ Heloisa , Maestrini Heloisa Andrade , Coelho Laura Fernandes , Balbino Marcos , Seixas Regina Cele Silveira
Published: June 2021

Purpose:

Late hypotony is an undesirable and challenging complication of glaucoma surgery. We describe our use of the Ologen Collagen Matrix to treat late hypotony developing after trabeculectomy.

Study design:

A retrospective study performed at three eye surgery centers in Brazil.

Participants:

Eighteen patients who underwent 19 eye surgeries.

Intervention:

Subconjunctival Ologen was implanted at the trabeculectomy sites to treat over-filtering or leaking blebs in patients experiencing late hypotony after trabeculectomy (obtained 6 months after glaucoma surgery). The primary outcome was the intraocular pressure (IOP); we gathered preoperative data records from 19 Ologen treated eyes and days 1, 7, 30, 60, and 180 postoperatively. The secondary outcomes included visual acuity and macular thickness measured via optical coherence tomography; we compared preoperative data to subsequent ones up to sixth-month-evolution.

Results:

Over the 6-month period, the IOP rose from 2.89 ± 1.59 mmHg preoperatively to 8.21 ± 3.46 mmHg ( p = 0.0001). Visual acuity improved from 0.33 ± 0.29 to 0.21 ± 0.31 LogMar ( p = 0.0013). Macular thickness fell from 325.62 ± 58.7 to 283.08 ± 47.35 µm ( p = 0.0097). We encountered two complications: one related to suture dehiscence following an ocular trauma and one instance of transitory choroidal detachment.

Conclusion:

Subconjunctival Ologen implants preserved bleb function and successfully treated post-trabeculectomy hypotony as revealed by data collected at the 6-month follow-up. Longer follow-up is necessary to confirm long-term efficacy and safety. There are no financial conflicts of interest to disclose.
Gracz fistula is a feasible option after two failed percutaneous arteriovenous fistulae
Authors: Shahverdyan Robert , Konner Klaus , Matoussevitch Vladimir
Published: June 2021

Two devices for the creation of an endovascular percutaneous (pAVF) endovascular (endoAVF) arteriovenous fistulae (AVF) are available: the Ellipsys and the WavelinQ-4F systems. The main difference is the location of the anastomosis, making it feasible to use both pAVFs and surgical Gracz-type AVF in an algorithm sequence. A 66-year-old male patient with end-stage kidney disease and HIV was referred for a creation of a dialysis access after failed peritoneal dialysis. A radial-radial WavelinQ-pAVF with simultaneous coil embolization of a brachial vein was created but failed within 4 weeks. Therefore, an Ellipsys-pAVF was successfully created between the proximal radial artery and perforating vein on the same arm. After 2 days, however, the Ellipsys-pAVF anastomosis occluded. The ipsilateral Gracz-AVF was created, anastomosing perforating vein with the antecubital brachial artery. Cannulations were started 28 days later. During the follow up of 807 days, the AVF remained patent with last known volume flow of 1500 ml/min and no need for secondary interventions. We report a successful creation of a Gracz-AVF after primary failed pAVFs created with both pAVF-systems in a single patient and in the same arm. Thus, based on that case we recommend creation of pAVF prior to Gracz-AVF as integral part of Vascular Access creation algorithm, based on each patient’s life plan.
Motivational factors underlying learner preferences for corrective feedback: Language mindsets and achievement goals
Authors: Papi Mostafa , Wolff Dominik , Nakatsukasa Kimi , Bellwoar Emily
Published: June 2021

The present study examines how learners’ language mindsets (beliefs about the malleability of language intelligence) and achievement goals predict learners’ preferences for different types of corrective feedback (CF). Questionnaire data were collected from 537 learners of Spanish as a foreign language at two North-American universities. Factor analytic and multiple regression results showed two clear patterns. A growth language mindset (the belief that language learning ability is malleable) predicted preferences for all types of CF whereas a fixed language mindset predicted a preference for conversational recast and absence of CF. A development-approach goal (concerned with improving one’s language competence) positively predicted learners’ preference for the explicit types of CF whereas a development-avoidance goal (concerned with maintaining one’s second language competence) positively predicted the more implicit types of CF. Demonstration-approach (concerned with displaying superior competence) did not predict any CF type and demonstration-avoidance (concerned with avoiding the display of incompetence) predicted a preference for absence of CF. Using an overarching cost–value model, we discuss how learners’ analysis of the self-presentation and ego costs as well as the value of different CF types have led to their preference for one versus another. Future directions and pedagogical implications are discussed.
Impacts of social and emotional learning (SEL) on English learning achievements in Hong Kong secondary schools
Authors: Bai Barry , Shen Bin , Wang Jing
Published: June 2021

With growing attention attached to young students’ social and emotional well-being besides their cognitive development, social and emotional learning (SEL) has been increasingly researched in general school education over the past decades with its positive effects on academic performance reported. However, SEL research has not emerged in English as a foreign language (EFL) learning contexts. To bridge the void, the current research aimed to profile Hong Kong secondary school students’ SEL competence level and examine the intricate relationships among the four SEL competence clusters (i.e. self-awareness, self-management, social awareness and social management) and English learning achievements. The results indicated an overall medium level of SEL competence among 315 secondary school grade level 3 students and suggested a gap between the students’ high level of awareness skills and their medium level of management skills. Structural equation modeling (SEM) analyses confirmed two mediation paths, thus highlighting the seminal mediating role of self-management skills in enhancing the effects of self-awareness and social awareness skills on English learning achievements. Important implications are discussed.
Self-reported experiences of siblings of children with life-threatening conditions: A scoping review
Authors: Tay Joanne , Widger Kimberley , Stremler Robyn
Published: June 2021

Sibling relationships are one of the most long-lasting and influential relationships in a human’s life. Living with a child who has a life-threatening condition changes healthy siblings’ experience. This scoping review summarized and mapped research examining healthy siblings’ experience of living with a child with a life-threatening condition to identify knowledge gaps and provide direction for future research. Studies were identified through five electronic databases. Of the 34 included studies, 17 used qualitative methods, four gathered data longitudinally and 24 focused on children with cancer. Four broad themes of sibling experience were identified across studies: family functioning, psychological well-being, social well-being, and coping. Siblings experienced challenges and difficulties over the course of the child’s illness. Future research should incorporate longitudinal designs to better understand the trajectory of siblings’ experiences and focus on a wider variety of life-threatening conditions.
An efficient method for vibration equations with time varying coefficients and nonlinearities
Authors: Yang Jinsong , Xie Jingsong , Chen Gaige , Chen Jinglong
Published: June 2021

An efficient method for solving vibration equations is the basis of the vibration analysis of a cracked multistage blade–disk–shaft system. However, dynamic equations are usually time varying and nonlinear, and the time required for solving is greatly increased accompanied by an increase in the model order caused by the multistage system and the nonlinearity caused by cracks. In this article, an efficient method for solving the time varying and nonlinear vibration equation is investigated. In the proposed method, the time varying terms are transformed into constant terms, while the local nonlinear matrix of the cracked blade is separated from the assembly stiffness matrix under the constraint of proper orthogonal decomposition (POD) transformation rules. Furthermore, the POD transformations of the constant terms and the linear assembled stiffness matrix can be implemented in the pretreatment steps to achieve a more efficient POD reduction operation. This research provides a method for efficiently performing the comprehensive and rapid analysis of nonlinear vibration characteristics of rotor systems.