bluuebunny/crossref_metadata_2025 huggingface dataset:
Regulatory T Cells Secrete IL10 to Suppress Neuroinflammation in Early Stage after Subarachnoid Hemorrhage
Authors: Zhou Jingyi , Yang Fan , Li Huaming , Xu Penglei , Wang Zefeng , Shao Fangjie , Shao Anwen , Zhang Jianmin
Published: July 2023

Objective: Accumulating evidence supports neuroprotective effects of regulatory T cells (Tregs) in response to brain injury. However, the precise mechanisms underlying the beneficial effects of Tregs on suppressing neuroinflammation after subarachnoid hemorrhage (SAH) remain unclear. Methods: We performed flow cytometry to detect the infiltration of Tregs into the brain at different time points after SAH. Behavioral tests, including Adhesive and Rotarod, were performed to assess neurological deficits in mice after SAH. Bulk RNA sequencing was used to investigate the transcriptomic change of Tregs infiltrating into the brain after SAH. qPCR was performed to verify the variation of inflammatory cytokines expression in the brain after Tregs exogenous infusion. FoxP3-DTR mice and Il10 gene KO mice were used to explore the mechanism of Tregs inhibiting neuron apoptosis after infiltrating the brain following SAH onset. Results: Peripheral Tregs infiltrated into the brain one day after SAH and gradually accumulated in the hemorrhagic hemisphere. An exogenous infusion of Tregs significantly improved the neurological function of mice after SAH, while poor recovery of neurological function was observed in Tregs depletion mice. Transcriptome sequencing data suggested that the immunosuppressive function of brain-infiltrated Tregs was significantly upregulated. qPCR showed that the expression of pro-inflammatory cytokines decreased in the brain of SAH mice after exogenous Tregs infusion. Bioinformatic analysis revealed that IL-10 and other cytokines secreted by brain-infiltrated Tregs were upregulated after SAH. Moreover, exogenous infusion of Il10 gene KO Tregs did not totally improve neurological function in SAH mice. Conclusions: Tregs infiltrated into the brain in the early stage after SAH and exerted neuroprotective effect by secreting IL-10 to suppress neuroinflammation and reduce neuron apoptosis.
Using an Internal State Variable Model Framework to Investigate the Influence of Microstructure and Mechanical Properties on Ballistic Performance of Steel Alloys
Authors: Peterson Luke , Horstemeyer Mark , Lacy Thomas , Moser Robert
Published: July 2023

An internal state variable (ISV)-based constitutive model has been used within a Lagrangian finite element analysis (FEA) framework to simulate ballistic impact of monolithic rolled homogenous armor (RHA) steel plates by RHA steel spheres and cylinders. The ISV model predictions demonstrate good agreement with experimental impact data for spherical projectiles. A simulation-based parametric sensitivity study was performed to determine the influence of a variety of microstructural and mechanical properties on ballistic performance. The sensitivity analysis shows that the lattice hydrogen concentration, material hardness, and initial void volume fraction are dominant factors influencing ballistic performance. Finite element simulations show that variation of microstructure properties could explain the reduced ballistic performance of high hardness materials previously documented in the literature. The FEA framework presented in this work can be used to determine material properties conducive to ballistic-impact resistance.
Fungal Osteomyelitis: A Systematic Review of Reported Cases
Authors: Asperges Erika , Albi Giuseppe , Truffelli Francesco , Salvaderi Andrea , Puci Flavia , Sangani Aurelia , Zuccaro Valentina , Scotti Valeria , Orsolini Paolo , Brunetti Enrico , Bruno Raffaele
Published: July 2023

Fungal osteomyelitis is considered a rare disease, and the published literature mainly comprises case reports, case series and narrative reviews. A systematic review was undertaken to provide a practice-based global perspective on this disease, focusing on epidemiology and treatment strategies. We searched MEDLINE, EMBASE and Cochrane Library between the 3rd and 8th of March 2023 using a predefined search string. We included studies with at least one patient with a diagnosis of fungal osteomyelitis published before the 1st of January 2023. We included all study designs except for reviews, and we excluded non-English languages and grey literature. After exclusion, 678 studies, mostly case reports, were included. Descriptive analysis was performed on 1072 patients. The most common aetiological agent was Aspergillus (26.5%), followed by Candida (20.7%) and Mucor (16.8%), and the bones most frequently involved were the vertebrae. We described the characteristics of patients divided by site of infection, and we found that diabetes mellitus, disseminated fungal infection, surgery and local lesion were major risk factors. We also successfully associated duration of treatment with outcome. We provided a general overview of this rare disease, and we highlighted the need for high-quality investigations on the subject.
Trace Element Characteristics of Pyrite and Arsenopyrite from the Golden Ridge Gold Deposit, New Brunswick, Canada: Implications for Ore Genesis
Authors: Cardenas-Vera Alan , MacDonald Moya , Lentz David R. , Thorne Kathleen G.
Published: July 2023

The Golden Ridge gold deposit is located in southwestern New Brunswick, in the Canadian Appalachians. Gold mineralization is consistently associated with acicular arsenopyrite, and to a lesser degree with pyrite, disseminated in host rocks, sulphide veinlets, quartz-carbonate veins, and the breccia matrix. According to petrographic-based textural differences, four types of pyrite and two types of arsenopyrite are recognized with associated assemblages. Based on SEM-BSE imaging and LA-ICP-MS spot analyses of the different types of pyrites and arsenopyrites, “invisible gold” (solid solution in the crystal lattice of pyrite and arsenopyrite or <100 nm nanoparticles) and micrometer-size inclusions were identified as the main forms of Au. Four syn-gold mineralization pulses of fluid are suggested. The initial hydrothermal fluid, which generated low-grade pyrite (Py-I) enriched in Sb, Pb, Cu, Co, Ni, and Bi, was followed by a second pulse of fluid enriched in arsenic and gold, generating coprecipitated Py-II and Asp-I. The third and fourth pulses were enriched in both arsenic and gold and precipitated Py-III, then coprecipitated Py-IV and Asp-II, which constitute the most important Au depositional episodes. The repeated occurrence of growth zones with Au enrichment in the arsenian pyrites (Py-II, Py-III, and Py-IV) indicate surface growth during metal deposition and disequilibrium crystallization processes.
Spatiotemporal Distribution of Salmonella enterica in European Hedgehogs in Northern Italy
Authors: Carrera Maya , Tolini Clara , Trogu Tiziana , Boscarino Andrea , Tranquillo Vito , Munari Martina , Callegari Emanuele , Tartari Davide , Moreno Ana , Rubini Silva
Published: July 2023

Growing attention is being given to the European hedgehog (Erinaceus europaeus) because of its synanthropic behaviour and its potential role in harbouring parasites, viruses, fungi and bacteria and disseminating them to several animals and humans. Salmonella are the most frequently detected zoonotic bacteria that hedgehogs could transmit through contaminating water and food sources with faeces. This study aimed to determine the prevalence and distribution of Salmonella spp. in wild hedgehogs in the Emilia-Romagna region (northern Italy). From 2019 to 2022, 212 European hedgehogs that died naturally were tested for Salmonella spp. through culture isolation. Positive samples were subjected to serological typing. A total of 82 samples tested positive for Salmonella spp., with the overall Bayesian posterior estimated prevalence ranging from 35% (95% CI: 23–47%) to a maximum of 45% (95% CI: 31–59%) during the years considered and with an overall prevalence calculated at 39% (95% CI: 33–45%). Salmonella enterica Enteritidis and Veneziana were the most prevalent detected serovars in 65% and 17% of the positive samples, respectively. Since 2021, S. Typhimurium, S. Typhimurium Monofasica, S. Zaiman, S. Hessarek, S. Muenster, S. Isangi serovars, S. enterica subsp. Diarizonae and S. enterica subsp. Houtenae have been detected. These findings show a high prevalence of Salmonella spp. in tested hedgehogs, suggesting an important role of this animal species in the epidemiology of potentially zoonotic serovars circulating in the Emilia-Romagna region.
Weed-Hoeing Periods in Cowpea Cultivation under Direct and Conventional Systems
Authors: de Sousa Eudinete Ribeiro , de Oliveira Fontes Larissa , da Costa Filho José Hamilton , Gurgel Antonio Leandro Chaves , Fonseca Wéverson Lima , Zuffo Alan Mario , Alencar Daniele Galvão , Silva Tairon Pannunzio Dias e , de Jesús Lacerda Julian Junio , Aguilera Jorge González , García José Antonio Rodríguez , Zevallos Renatto Nicolino Motta , Morales-Aranibar Luis , Luna Alfredo Modesto Marcavillaca , Gonzales Hebert Hernán Soto
Published: July 2023

Weed coexistence with an agricultural crop can negatively affect its growth, development, and yield. From this perspective, this study aimed to evaluate weed management strategies and their effect on the agronomic parameters of cowpea cultivation in direct (SPD) and conventional (SPC) planting systems. The experiment was set up in a completely randomized block design with a split-plot arrangement with four replications. The plots received a source of variation referring to the planting systems (direct and conventional planting), and the subplots corresponded to ten weed management strategies (manual hoeing 18 days after planting (DAP); at 36 DAP; at 54 DAP; at 18 and 36 DAP; at 18 and 54 DAP; at 18 and 72 DAP; at 36 and 54 DAP; at 36–72 DAP; at 18, 36, and 54 DAP; and a control with no hoeing). Density and dry mass evaluations of the cowpea plants were performed at harvest (72 DAP) by determining the number of pods per plant, pod length, number of grains per pod, 1000-grain mass, and yield. A total of 28 species distributed in 12 botanical families were identified in the two cultivation systems. The family Poaceae showed the highest frequency, with 25% of the species identified. At the end of the assay, treatment 20 had the highest positive influence and provided significant quantitative gains to the complex of traits related to cowpea production (SPD and hoeing at 18, 36, and 54 DAP). UPGMA cluster analysis and canonical discriminant analysis were performed and allowed a better classification of the evaluated treatments. It was observed that the first two canonical variables explained 90.8% of the total variance contained in the original variables. The use of SPD with weeding at 18, 36, and 54 days after planting provides greater weed control and significant quantitative gains for the complex of characteristics related to cowpea production. The results underscore the importance of choosing the correct cropping system and implementing effective weeding practices to optimize weed control and improve crop performance.
Orthogonal Experimental Study on the Construction of a Similar Material Proportional Model for Simulated Coal Seam Sampling
Authors: Pang Jie , Zhang Xinghua , Zhang Bailin
Published: July 2023

The development of similar materials is crucial for conducting simulated coal seam sampling experiments. These materials must comprehensively consider the similarity of mechanical properties with raw coal. To ensure a high degree of similarity between the simulated coal seam similar material and raw coal, cement and coal powder were selected as the main influencing factors. This study employed sensitivity analysis and analysis of variance methods to investigate the impact of various factors on the compressive strength, elastic modulus, Poisson’s ratio, and density of comparable materials. The influence of moisture content on the compressive strength and elastic modulus of these materials was also analyzed, as well as the effect of cement and coal powder on moisture content. The results showed that cement was the main controlling factor for the mechanical properties of similar materials. Moreover, the variation of tensile strength and elastic modulus of similar materials in response to the moisture content can be divided into three distinct stages. Based on the influence law, the ratio formula of coal powder and cement for the strength and moisture content of similar materials was obtained, and a proportional model for simulated coal seam sampling similar materials was constructed. The approximate ranges of various parameters that can be achieved by this model are as follows: compressive strength of 1~11.4 MPa, elastic modulus of 0.27~3.62 GPa, Poisson’s ratio of 0.229~0.357, and density of 1.044~1.341 g·cm−3. The error in mechanical parameters for this model has been verified to be within 20%. Finally, similar materials were created for simulated coal seam sampling by employing an appropriate ratio. A self-developed drilling test platform was utilized to successfully conduct an experiment, further demonstrating the reliability of the proportional model.
A Real-Time Streaming System for Customized Network Traffic Capture
Authors: Costin Adrian-Tiberiu , Zinca Daniel , Dobrota Virgil
Published: July 2023

Logging network traffic offers valuable insights into data flow, enabling the proactive analysis and troubleshooting of issues as they arise. Moreover, it provides a means to access and examine the exchanged information among network users that would otherwise be inaccessible. To enhance network traffic analysis, the integration of innovative technologies that facilitate real-time querying and pattern matching proves indispensable. This research paper presents a system that exemplifies such advancements—an innovative network traffic logging tool. The tool specifically focuses on performing real-time network packet transfer to Apache Kafka and ksqlDB, leveraging their capabilities to ensure swift and dependable storage of network packets in Apache Kafka topics. By showcasing this solution, the paper demonstrates the benefits and effectiveness of employing modern technologies for network traffic analysis and management.
BSafe-360: An All-in-One Naturalistic Cycling Data Collection Tool
Authors: Duran Bernardes Suzana , Ozbay Kaan
Published: July 2023

The popularity of bicycles as a mode of transportation has been steadily increasing. However, concerns about cyclist safety persist due to a need for comprehensive data. This data scarcity hinders accurate assessment of bicycle safety and identification of factors that contribute to the occurrence and severity of bicycle collisions in urban environments. This paper presents the development of the BSafe-360, a novel multi-sensor device designed as a data acquisition system (DAS) for collecting naturalistic cycling data, which provides a high granularity of cyclist behavior and interactions with other road users. For the hardware component, the BSafe-360 utilizes a Raspberry Pi microcomputer, a Global Positioning System (GPS) antenna and receiver, two ultrasonic sensors, an inertial measurement unit (IMU), and a real-time clock (RTC), which are all housed within a customized bicycle phone case. To handle the software aspect, BSafe-360 has two Python scripts that manage data processing and storage in both local and online databases. To demonstrate the capabilities of the device, we conducted a proof of concept experiment, collecting data for seven hours. In addition to utilizing the BSafe-360, we included data from CCTV and weather information in the data analysis step for verifying the occurrence of critical events, ensuring comprehensive coverage of all relevant information. The combination of sensors within a single device enables the collection of crucial data for bicycle safety studies, including bicycle trajectory, lateral passing distance (LPD), and cyclist behavior. Our findings show that the BSafe-360 is a promising tool for collecting naturalistic cycling data, facilitating a deeper understanding of bicycle safety and improving it. By effectively improving bicycle safety, numerous benefits can be realized, including the potential to reduce bicycle injuries and fatalities to zero in the near future.
“I Don’t Feel like an Adult”—Self-Perception of Delayed Transition to Adulthood in NEET Sample
Authors: Parola Anna , Donsì Lucia , Parrello Santa
Published: July 2023

Nowadays, there has been a debate about factors still crucial for the actual definition of adulthood and the role played by uncertainty in employment, the economic crisis, changing cultural contexts, and globalization in the adulthood transition. This study aimed to provide a deeper understanding of the self-perception of the transition to adulthood among the Italian NEET (young people not engaged in education, employment, or training). A group of 53 NEETs were asked to assess their transition from adolescence to adulthood by rating themselves on a scale from 1 (=adolescence) to 7 (=adulthood). They were also asked to reflect on the reasons why they felt like adults or not. The qualitative data were coded using the criteria of adulthood attainment proposed by Arnett’s markers of adulthood scale. Analysis showed that the category with the highest frequency was role transition, and almost all the NEETs in this category felt “in-between”. The excerpts portrayed the centrality of work as a crucial factor in self-perception as an adult. The research emphasizes the importance of mixed-methods research to understand where and how people feel about the transition to adulthood, aspects that are difficult to grasp using only quantitative data.
Translation and Adaptation of the Adult Developmental Coordination Disorder/Dyspraxia Checklist (ADC) into Asian Uzbekistan
Authors: Saidmamatov Orifjon , Jammatov Jasurbek , Sousa Cláudia , Barros Rita , Vasconcelos Olga , Rodrigues Paula
Published: July 2023

Developmental Coordination Disorder (DCD) is a neurodevelopmental condition that emerges in childhood and its symptoms continue through adulthood. The Adult Developmental Coordination Disorders/Dyspraxia Checklist was the first instrument used to screen adults with possible DCD. The psychometric characteristics of the Uzbek version of the scale were explored. An independent translation of the questionnaire from the original version into the Uzbek language was made. The sample comprised 301 Uzbekistan adults, aged between 17 and 42 years old (M = 20.66; SD = 2.26). Analyses were performed using R software (4.1.0). Descriptive analysis, exploratory factor analysis, and evidence of reliability in terms of internal consistency were assessed using the psych package (2.1.6), intraclass correlation coefficients were assessed using the irr package (0.84.1), and weighted Kappa were assessed using vcd package (1.4-10). To analyse the factor structure of the ADC scale, when applied to an Uzbekistan sample, exploratory factor analysis (EFA) was performed. In the Uzbek version, a one-factor structure was identified, and moderated psychometric properties were found, which makes it a possible alternative to the original scale when applied to adults. This Uzbek version reduces respondents’ fatigue since it is smaller than the original one. More studies are needed to confirm the cut-off scores of this new version.
Comparing Additionality of Tuberculosis Cases Using GeneXpert or Smear-Based Active TB Case-Finding Strategies among Social Contacts of Index Cases in Nepal
Authors: Gurung Suman Chandra , Dixit Kritika , Paudel Rajan , Sah Manoj Kumar , Pandit Ram Narayan , Aryal Tara Prasad , Khatiwada Shikha Upadhyay , Majhi Govind , Dhital Raghu , Paudel Puskar Raj , Shrestha Gyanendra , Rai Bhola , Budhathoki Gangaram , Khanal Mukti , Mishra Gokul , Levy Jens , Van de Rest Job , Thapa Anchal , Ramsay Andrew , Squire Stephen Bertel , Lönnroth Knut , Basnyat Buddha , Caws Maxine
Published: July 2023

This study compares the yield and additionality of community-based active tuberculosis (TB) active case-finding strategies using either smear microscopy or GeneXpert as the TB diagnostic test. Active case-finding strategies screened social contacts of index cases and high-risk groups in four districts of Nepal in July 2017–2019. Two districts (Chitwan and Dhanusha) applied GeneXpert testing and two districts (Makwanpur and Mahotarri) used smear microscopy. Two control districts implemented standard national TB program activities. Districts implementing GeneXpert testing screened 23,657 people for TB, tested 17,114 and diagnosed 764 TB cases, producing a yield of 4.5%. Districts implementing smear microscopy screened 19,961 people for TB, tested 13,285 and diagnosed 437 cases, producing a yield of 3.3%. The screening numbers required were 31 for GeneXpert and 45.7 for smear districts. The test numbers required were 22.4 and 30.4 for GeneXpert and smear. Using the TB REACH additionality method, social contact tracing for TB through GeneXpert testing contributed to a 20% (3958/3322) increase in district-level TB notifications, smear microscopy 12.4% (3146/2798), and −0.5% (2553/2566) for control districts. Therefore, social contact tracing of TB index cases using GeneXpert testing should be implemented throughout Nepal within the TB FREE initiative to close the notification gap and accelerate progress toward END TB strategy targets.
Charged Kaon Femtoscopy with Lévy Sources in sNN = 200 GeV Au+Au Collisions at PHENIX
Authors: Kovács László
Published: July 2023

The PHENIX experiment measured two-particle Bose–Einstein quantum-statistical correlations of charged kaons in Au+Au collisions at sNN = 200 GeV. The correlation functions are parametrized assuming that the source emitting the particles has a Lévy shape, characterized by the Lévy exponent α and the Lévy scale R. By introducing the intercept parameter λ, we account for the core–halo fraction. The parameters are investigated as a function of transverse mass. The comparison of the parameters measured for kaon–kaon with those measured from pion–pion correlation may clarify the connection of Lévy parameters to physical processes.
Comparative Analysis of Methods for Somatic Cell Counting in Cow’s Milk and Relationship between Somatic Cell Count and Occurrence of Intramammary Bacteria
Authors: Hisira Vladimír , Zigo František , Kadaši Marián , Klein Róbert , Farkašová Zuzana , Vargová Mária , Mudroň Pavol
Published: July 2023

The aim of this study was to compare three on-farm commercial methods for the indirect detection of subclinical mastitis in dairy cows: the California mastitis test (CMT), the Porta side somatic cell count milk test (Porta SCC), and the DeLaval cell counter (DCC), with the Fossomatic cell count (FSCC), and to evaluate the relationship between the determined somatic cell count SCC and the occurrence of intramammary pathogens in the milk of dairy cows. A total of 284 sensory unchanged mixed milk samples, collected during the milking on a dairy farm, were analyzed in this study for somatic cell counts by the mentioned on-farm tests. Quarter milk samples (n = 583) from all the selected cows were cultured. The agreement, sensitivity, and specificity of the three indirect commercial diagnostic tests (the CMT, the Porta SCC, and the DeLaval cell counter) were calculated, and the FSCC was used as the gold standard. The results were analyzed statistically using the Pearson correlation test and the paired t-test. The CMT matched with the FSCC in 83.1% of the samples, with the Porta SCC in 80.6%, and with the DCC in 80.3% of the samples. The sensitivity and specificity reached 81.0% and 92.9% for the CMT, 79.4% and 90.7% for the Porta SCC, and 75.8% and 97.5% for the DCC, respectively. The correlation between the FSCC and the Porta SCC was 0.86 (p < 0.0001), and between the FSCC and the DCC, it was 0.92 (p < 0.0001). The differences between them were insignificant. Bacteria were detected in 130 (22.3%) quarter milk samples. The most prevalent bacteria were Enterococcus spp. (36.2%), followed by E. coli (20%), coagulase-negative staphylococci (13.1%), A. viridans (9.2%), Streptococcus spp. (9.2%), Proteus spp. (6.2%), and S. intermedius (3.9%). Contagious isolates (S. aureus) were detected in 3 quarter milk samples (2.3%). The agreement between the individual tests and the microbiological culture was as follows: 69.2% for the CMT; 73.7% for the Porta SCC; 71.6% for the DCC; and 76.5% for the FSCC. Higher SCCs were detected in the milk samples contaminated with bacteria than in the healthy milk (p < 0.001). No significance was found between the presence of individual species of intramammary pathogens and the different levels of SCCs. Based on the results, bacteria are the predominant cause of subclinical mastitis. The increased SCC of some milk samples with no presence of bacteria meant that the increase could have been caused by numerous other agents (viruses, fungi, or algae) or factors for mastitis in the dairy industry.
The Effectiveness of Terlipressin (Remestyp) in Performing Myomectomy During Cesarean Section
Authors:   Odintsovo Maternity Hospital, Kuneshko N.F. ,   Kaluga Regional Clinical Hospital, Tsaroeva I.Kh. , Kosmakova Yu.O.
Published: July 2023

A study was conducted on the effectiveness of terlipressin during myomectomy during cesarean section in pregnant women with uterine fibroids. The drug has demonstrated high efficacy, significantly reducing the level of intraoperative blood loss and shortening the duration of surgery.
Neoplasms of the Pelvic Cavity in Pediatrics. Features of Differential Diagnosis
Authors:   A.I. Yevdokimov Moscow State University of Medicine and Dentistry, Adamyan L.V. , Sibirskaya Ye.V. , Karachentsova I.V. ,   Russian Children’s Clinical Hospital of N.I. Pirogov Russian National Research Medical University,   N.I. Pirogov Russian National Research Medical University,   I.M. Sechenov First Moscow State Medical University, Skapenkov I.N. , Avetisyan D.S. ,   V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology, Krylova Ye.I. , Nakhapetyan Ye.D.
Published: July 2023

The frequency of detection of stromal gastrointestinal tumors in children and adolescents is about 0.4% of the total number of diagnosed GISTs. These tumors can occur throughout the gastrointestinal tract. During the instrumental research, misinterpretation of tumor origin is possible. For this reason, the consistent use of a variety of non-invasive diagnostic methods is extremely important in the preoperative period. We present a case report of a rare GIST detection in pediatrics, which at the stage of noninvasive diagnostic studies was determined as a pelvic tumor. It was possible to accurately determine its origin only after diagnostic laparoscopy. We also provide a description of instrumental and laboratory research methods for the differential diagnosis of the abdominal and pelvic cavities neoplasms
The Effectiveness of the Dosed Cream Acilact Duo in Patients with Bacterial Vaginosis
Authors:   Moscow Regional Research Institute of Obstetrics and Gynecology, Tikhomirova Ye.V. , Balan V.Ye. , Kruchinina Ye.V. , Balan P.V. , Orlova S.A. , Titchenko Yu.P. , Levkovich Ye.A. , Yatsyuk V.Ya.
Published: July 2023

Bacterial vaginosis is a clinical condition in which the normal vaginal microflora, predominantly lactobacilli, is replaced by other microorganisms, mainly anaerobes. The goal of treating bacterial vaginosis is to restore the normal microflora of the vagina, to delay the growth of microorganisms that are not characteristic of this vaginal microcenosis. The purpose of the study was to evaluate the effectiveness of various methods of combined two-stage treatment of bacterial vaginosis in women of reproductive age. Material and methods. The study included 50 patients aged 18 to 45 years (mean age 29.6 ± 4.5 years) with bacterial vaginosis. The first group consisted of 25 patients who received Clindamycin 2% cream for 7 days, dose vaginally at night. For the second stage of therapy in this 1 group, acidophilus bacteria + vitamin-mineral-protein-peptide complex Superlimfly (Acylact Duo) were used, suppository time per day at night intravaginally for 10 days. The second group consisted of 25 patients who received Clindacimin cream for 7 days, dose vaginally at night. For the second stage of therapy, a preparation containing a lyophilized culture of lactobacilli L. casei rhamnosus Doderleini was used, at least 1 × 108 CFU, capsule in the vagina at night for 14 days. Results. The effectiveness of BV therapy was 49% (n = 46). The duration of remission was 24.1 ± 2.1 days (n = 24) in the group of women receiving adjuvant therapy with Acilact Duo dosed cream, and 19.9 ± 2 3. days (n = 22) in the comparison group. In all patients, the average vaginal pH before therapy was 5.5 ± 0.4. In group1 participants, after therapy, the pH was 4.54 ± 0.143 , in group 2 patients, the average vaginal pH was 4.976 ± 0.241. Among the patients of both groups, vaginal dysbiosis of varying severity was detected before treatment (normocenosis was not detected). After therapy, in patients of group, normocenosis of the vagina was achieved in 88% (22/25), in participants of group 2, normocenosis was noted in 72% (18/25). At visit (in 45 days) in women of the group 1 84% (21/25), in the participants of the group 2 – normocenosis was noted in 64% (16/25). Conclusions. Acidophilic bacteria + vitamin-mineral-protein-peptide complex Superlymfly (in which dosed Acylact Duo) quickly restores the optimal acidity of the vagina (pH value) and promotes the growth of the number of beneficial lactobacilli, as a result of which it creates an optimal and natural microflora that prevents the appearance of dysbiosis in patients of reproductive age
Associations of Leptin and Adiponectin in Irritable Bowel Syndrome Patients with Overweight and Obesity
Authors:   Omsk State Medical University, Fedorin M.M. , Livzan M.A. , Gaus O.V.
Published: July 2023

Irritable bowel syndrome (IBS) in overweight and obese individuals is characterized by a more severe course than in patients with normal weight. The purpose. To assess the level of adipokines (leptin and adiponectin) in blood serum, the correlation of these laboratory markers with the clinical manifestations of IBS, quality of life, eating habits, and signs of anxiety and depression based on the results of using a special questionnaire in patients with IBS. Material and methods. An open cohort cross-sectional study was conducted with the inclusion of 175 participants aged 18 to 44 years (mean age 30.06 ± 6.15 years). Group 1 included 100 obese or overweight IBS patients aged 18 to 44 years (mean age 30.63 ± 6.37 years, BMI 25.88 ± 6.28 kg/m2). In group 1, subgroup 1A included 50 people with IBS associated with overweight or obesity. In subgroup 1B – 50 people suffering from IBS, with normal weight. Group 2 included 75 people without IBS, aged 19 to 43 years (mean age 29.31 ± 5.81 years, BMI 27.80 ± 6.20 kg/m2). Subgroup 2A included 50 non-IBS participants who were overweight or obese. Subgroup 2B included 25 apparently healthy participants. IBS symptoms were assessed using a 10-point scale. Using verified questionnaires, the severity of gastrointestinal symptoms, the presence of anxiety and depression, the level of specific anxiety, quality of life and eating habits were assessed. Results. IBS patients with overweight and obesity are characterized by higher levels of leptin and low levels of adiponectin than patients with normal weight (Mann – Whitney test, p < 0.05). Adipokine levels correlate with high cravings for sweet, fatty, starchy, and salty foods. A higher concentration of leptin is characteristic of patients suffering from IBS with a predominance of constipation (Mann – Whitney test, p < 0.05). High levels of leptin and low levels of adiponectin in overweight and obese IBS patients correlate with more severe symptoms of abdominal pain, flatulence, poor quality of life, and more frequent signs of anxiety and depression (Spirmen test p < 0.05, Mann – Whitney test, p < 0.05). Conclusion. The results obtained suggest a significant role of adipokines in the formation of more severe symptoms in IBS patients with overweight and obesity compared to patients with normal weight
PR TOOLS IN THE IMPLEMENTATION OF A COMPANY BRAND LOYALTY PROGRAM
Authors:   Chernivtsi Institute Trade and Economics of SUTE, Chernivtsi, Yurii Chaplinskyі , Olena Bozulenko ,   Chernivtsi Institute Trade and Economics of SUTE, Chernivtsi
Published: July 2023

Formation of an effective enterprise management system requires emphasis on the use of modern marketing tools. One of the priority elements of achieving the strategic and tactical goals of marketing activities of enterprises is the active use of marketing communications and their implementation in practical activities, including with the aim of creating a powerful brand. Among the main tools for achieving the company's marketing goals regarding branding, the formation and maintenance of the company's consumer loyalty to its brand should be considered. The effectiveness of the implementation of the brand loyalty program is based on the concept of integrated marketing communications, which involves the simultaneous application of individual elements of the marketing communication mix. Such integration is aimed at the use of basic and synthetic tools of marketing communications in the process of developing and implementing the company's brand loyalty program in the target market. Some of such tools of marketing communications, which are actively used in the practical activities of the enterprise in order to support the brand loyalty program, are means of public relations (Public relations, PR), the use of which allows to improve both the positive image of the enterprise in general, and the perception of individual programs brand loyalty. The main stages of PR support in the process of implementing a brand loyalty program are: research and definition of the basic elements of the PR strategy of information and communication support; development of a complete program of PR support for the brand loyalty program; practical implementation of the information and communication support program and evaluation of the effectiveness of the tools used in the implementation of the PR program. At the same time, both traditional and innovative tools and means of PR support of the brand loyalty program can be used. The implementation of the brand loyalty program will allow enterprises to improve their own image, which in the future will provide an opportunity to bring the management of marketing activities to a new high-quality level.
ACCOUNTING AND ANALYTICAL COMPONENT OF THE INFORMATION SYSTEM ENSURING THE ECONOMIC SECURITY OF THE ENTERPRISE
Authors:   Chernivtsi Institute Trade and Economics of SUTE, Chernivtsi, Konon Bagrii , Alla Chornovol ,   Chernivtsi Institute Trade and Economics of SUTE, Chernivtsi, Serhii Rylieiev ,   Chernivtsi Institute Trade and Economics of SUTE, Chernivtsi
Published: July 2023

In today's conditions of a full-scale war with the Russian Federation, every business entity in Ukraine operates in a complex, unstable and dynamic environment, the changes of which are accompanied by constant strengthening of competition, acceleration of inflationary processes, growth of business risks and the danger of destruction of logistics and partnership ties. Currently, the quantitative and qualitative properties of the enterprise regarding the ability to survive and ensure development in the conditions of the destabilizing effect of unpredictable and hard-to-forecast external and internal factors come to the fore. The enterprise's ability to timely implement anti-crisis measures, effective functioning and dynamic development is an indicator of its economic security. Therefore, the accounting and analytical component of the information system for ensuring economic security is an extremely urgent problem that needs to be solved and is under increased attention of both domestic and foreign scientists and specialists in financial and economic security. The purpose of the article is to reveal the possibilities and prospects of creating a complex accounting and analytical information system at the enterprise, which allows achieving systematicity and complexity, structure and organization of the enterprise management process within the framework of the concept of economic security. The article considers the importance of accounting and analytical information necessary for enterprise management. The main sources of threats to the economic security of the enterprise, which are formed in the accounting system, are revealed. The internal ФІ НА НС И , О БЛ ІК І О П ОД АТК УВ А Н НЯ Випуск І (89), 202338 control system of the enterprise is presented as the main element of economic security. A scheme for the movement of accounting management information has been developed. The main tasks of the complex information accounting and analytical system for ensuring the economic security of the enterprise are outlined. It has been proven that information security in Ukraine during the war must necessarily be subject to the criteria of confidentiality, integrity and availability.
PENGARUH PEMBERIAN AIR REBUSAN DAUN SALAM TERHADAP PENURUNAN TEKANAN DARAH PADA WANITA LANSIA
Authors: Mukarromah Asti , Aulya Yenny , Suciawati Anni
Published: July 2023

Hipertensi adalah kondisi tekanan darah tinggi di dalam arteri yang dapat menaikkan resiko penyakit kardiovaskular. Pengobatan non farmakologi yang dapat digunakan untuk membantu penurunan tekanan darah tinggi diantaranya dengan daun salam (Syzygium polyanthum). Tujuan dari penelitian ini untuk melihat pengaruh dari air rebusan daun salam terhadap tekanan darah. Jenis penelitian ini quasi-experiment dengan pretest-posttest with control group design. Pengambilan sampel dengan teknik purposive sampling sebanyak 38 responden. Analisis yang digunakan menggunakan uji Paired t-test dan analisis uji beda menggunakan uji Independent t-test. Selisih rata-rata penurunan tekanan darah antara sebelum dan setelah intervensi diperoleh selisih tekanan sistolik 24.43 mmHg dan tekanan diastolik 3.84 mmHg. Hasil uji Paired t test pada tekanan sistolik p value 0.000 (<0.05) dan tekanan diastolik p value 0,001 (<0,005). Ada pengaruh pemberian air rebusan daun salam terhadap penurunan tekanan darah wanita lansia.

 

Abstract

Hypertension is a condition of high blood pressure in the arteries that can increase the risk of cardiovascular. One of the non-pharmacological treatments to reduce high blood pressure is bay leaf (Syzygium polyanthum). This study to determine the effect of consumption of bay leaf decoction water on reducing blood pressure in elderly women. This study used quasi-experiment with pretest-posttest with control group design. The sampling used a purposive sampling technique which involved 38. The analysis used uses the Paired test and Independent test. The average difference blood pressure between before being given bay leaf decoction water was systolic blood pressure of 24.43 mmHg and the average blood pressure of diastolic was 3.84 mmHg. Paired t-test results of systolic obtained p value 0.000 (<0.05) and diastolic obtained p value 0.000 (<0.05). There is an effect of giving bay leaf decoction water on reducing blood pressure in elderly women.
PİR SULTAN’IN ŞİİRLERİNDE KÜLTÜREL BELLEĞİN İZLERİ
Authors: KOÇAK AYNUR , UĞURCAN FATMA ZEHRA
Published: July 2023

Various studies have been conducted on memory. One of the most striking of these is the theory of “cultural memory” put forward by J. Assmann. According to this theory, memory is divided into two. Communicative memory includes memories that an individual shares whit contemporaries. This memory is formed in the present moment and continues to exist only as long as its bearers live. Cultural memory, on the other hand, is based on a long time ago. This memory contains the legendary origin history of the society and striking points of the past. The Alawi community, as a community that has created their own cultural World and gathered around a belief, has a deeply embedded cultural memory. In the framework of caliphate discussions after the death of the Prophet Muhammad, Ali and his sons lived in the memory of the Alawi community as painful memories. The battle of Karbala has a special place in Alawi culture. Karbala has become a symbol of pain, grief, injustice in the Alawi culture, and all the figures and motifs associated with Karbala have taken a deep place in cultural memory of Alawi community. These often come to the surface of memory with various remembering figures, causing the past to be relived and reconstructed. One of the most precious folkloric products that can trace the cultural memory of the Alawi community is the poems of Pir Sultan. In this study, traces of cultural memory were traced in Pir Sultan’s poems, and the figures of remembrance, which are of great importance for the Alawi society, were examined. The aim of the study to to determine how and trough which sources the cultural memory of Alawi community is reflected in Pir Sultan’s poetry, and how this affects Pir Sultan as a poet. In this direction as a result of research is determined that Pir Sultan’s memory is shape by the folklore of Alawi community and the remembrance figures which reflect to the poems are separated positively and negatively from the point of Pir Sultan’s view. Keywords: Culture of Alawi, Pir Sultan, Cultural Memory, Kerbelâ.
AYDIN EYALETİNDE KONAR-GÖÇER BİR AŞİRET: 2973 NUMARALI OSMANLI NÜFUS DEFTERİNE GÖRE ALAŞEHİR KAZASINDA İKİ TAHTACI TOPLULUĞU
Authors: KAFTANLI UFUK ALİ
Published: July 2023

This article focuses on a semi-nomadic Kizilbash-Alevi Tahtacı tribe that lived in the Kaza of Alaşehir in the Eyalet of Aidin (Aydın) in the first half of the 19th century. In the analysis, which approaches the topic of the examination with a micro-historical viewpoint, the tribal population register numbered 2973 was used to reveal the socio-economic structure of the Tahtacı tribe. The study is made up of three substantial parts. In the first part, in the light of relevant journey notes and archive documents, three villages (Tahtacı, Tahtacı Bektaşlar, Tahtacı Alandız) where Tahtacı communities were located in Alaşehir in the first phase of the 20th centurywas identified. Then, the liaisons of these settlement centers with the Tahtacıs of Kızılçukur and Karacaali, who were inscribed in the aforesaid register in the first half of the 19th century, were questioned. In the second part, two separate communities of the Tahtacı tribe, encountered in the periphery of Kızılçukur and Karacaali villages, were evaluated by demographic and socio-economic criteria within the possibilities of the population register numbered 2973. In the third chapter, the symbiotic ligament established between the extensions of the Tahtacı tribe in two different places that are close to each other is demonstrated, and their semi-nomadic idiosyncrasy is interpreted from a comparative aspect. In the conclusion part, the raw data of the related population register for Tahtacıs in the region are presented by socio-demographic and economic factors. As a result, for the first time, a local example of the micro-historical “from below” historiography method was created for the Alaşehir Tahtacıs. Keywords: Kizilbash-Alevism History, Ottoman Tahtacıs, Alaşehir Tahtacıs, Woodcraft, Population Registers, Temettuat Registers, Semi-Nomadism, Settlement.
BAYAT BOYUNUN NEVŞEHİR’DEKİ UZANTILARI: AYHAN KÖYÜ MEZAR TAŞLARI
Authors: KAVALÇALAN ENES
Published: July 2023

The Ayhan village of Avanos district of Nevşehir and the decorated tombstones in the village is the subject of this study. The village was founded by the Shambayadi tribe of the Bayat tribe of the Oghuzs. Because of there are no written documents about the foundation of the village, it is not known exactly when the settlement started. According to the narratives, the village was founded by Ayhan Baba in the 13th century. However, there are no artifacts from this period in the village or its surroundings. With this study, it is aimed to transfer the data obtained about the history of the village based on the tombstones of the village and the inscriptions on them. One of the aims of the study is to examine and introduce of ornaments on the tombstones and show the similarities between them and the motifs that used by other Turkmen tribes. In this context, 31 decorated and inscribed tombstones in Ayhan village were examined, the measurements of the tombs were taken, the decorations were also photographed and drawings were made. While a bird figure is found among the decorations, it is seen that mostly herbal and geometric motifs are preferred. Another factor taken into consideration is the headdresses. Of the 18 headdresses on the tombstones, 13 are cylindrical and 5 are overflow turbans. Because of the information that conveyed in the inscriptions was limited to the name, surname and year of death of the person, it could not be determined whether the titles changed according to social status. In the conclusion part, based on the fact that the earliest inscription belongs to 1810, it is suggested that the village was founded towards the end of the 17th century and reasons of this are emphasized. Keywords: Tomb Stone, Ayhan Village, Avanos, Shambayadi, Alevi.
ORHAN PAMUK’UN KAFAMDA BİR TUHAFLIK ADLI YAPITINDA ALEVİLİK İNANCI
Authors: DEMİR ERDİ
Published: July 2023

The subject of the study is related to the belief of Alevism in the novel titled Bir Oddity in My Head by Nobel Prize-winning author Orhan Pamuk. Orhan Pamuk's novel A Strangeness in My Head has a rich content in the context of the belief of Alevism, the world of meaning and its practices. In the research, discourses about the belief and identity of Alevism were interpreted and summarized by using the opportunities of literature sociology. As a matter of fact, the sociology of literature is the discipline of describing the lifestyle, values, beliefs, economic systems, thought structure of the period in which the work was written with the unique characteristics of literature. In this article, the phenomenon of Alevism is taken as the center of the research; the practices of Alevism culture, the perspective of society on Alevism belief and identity, and how Alevism is represented are examined. As a result of the research, it was understood that narrow-minded and hamas-filled people who migrated from the countryside to the suburban districts of Istanbul evaluated social groups with Alevism belief from a Sunni-centered perspective, and Alevi citizens living Istanbul in the 1970s were seen as other, undesirable and unwelcome people in society. It has been determined that Alevi individuals are exposed to discrimination and exclusion, especially in the family, marriage institution, religion, education, business life, military and social life. Keywords: A Strangeness In My mind, Alevism, Culture, Identity, Faith, Othering.
Career Development in Institutional Research
Authors: Johnson Mark
Published: July 2023

A major issue for the professional in institutional research is how one develops a successful career. This is not a topic likely to be found in the annual work plan of an office of institutional research, but it is one that should lend itself readily to the special skills of institutional research—i.e., the skills of self-study. This report has been prepared at the request of the AIR Professional Development Services (PDS) Board, created in 1981 to develop programs designed to meet the education needs of AIR members. The paper has two objectives: (1) to provide some basic insights into career development in insights that may be of general interest to the membership, and (2) to assist the PDS Board in program development.