bluuebunny/crossref_metadata_2025 huggingface dataset:
Outcomes and Clinical Relevance of a 16-Gene Pharmacogenetic Panel Test for Medication Management - A Cohort Study in 135 Patients
Authors: Niedrig David , Rahmany Ali , Heib Kai , Hatz Karl-Dietrich , Ludin Katja , Burden Andrea , Béchir Markus , Serra Andreas , Russmann Stefan
Published: November 2020

Background and Purpose: There is an increasing number of evidence-based
indications for pharmacogenetic (PGx) tests and a growing demand for PGx
screening. We aimed to evaluate clinical relevance of a 16-gene panel
test for PGx-guided pharmacotherapy. Experimental Approach:
Observational cohort study of subjects tested with a PGx panel for
variants of ABCB1, COMT, CYP1A2, CYP2B6, CYP3A4, CYP3A5, CYP2C9,
CYP2C19, CYP2D6, CYP4F2, DPYD, OPRM1, POR, SLCO1B1, TPMT and VKORC1.
Specialized clinical pharmacology consultations with PGx-guided
pharmacotherapy management were supported by the PGx expert system
SONOGEN XP. Study outcomes were PGx-based changes and recommendations
regarding current and potential future medication. Key Results:
PGx-testing was triggered by specific drug-gene pairs in 102 subjects,
whereas screening was performed in 33. Based on PHARMGKB expert
guidelines the 16-gene panel identified at least one “actionable”
variant relevant for current or potential future medication in all 135
(100%) tested patients. Drugs that triggered PGx-testing were
clopidogrel in 60, tamoxifen in 15, polypsychopharmacotherapy in 9,
opioids in 7, and other in 11 patients. Among those, PGx variants
resulted in clinical recommendations to change PGx-triggering drugs in
33 (32.4 %), and other current pharmacotherapy in 23 (22.5%).
Conclusion and Implications: The 16-gene PGx panel detected clinically
relevant variants in a high proportion of tested patients, and SONOGEN
XP supported their interpretation based on latest evidence. Additional
costs of panel vs. single gene tests are moderate, and the efficiency of
PGx panel testing challenges traditional cost-benefit calculations for
single drug-gene pairs. However, PGx-guided pharmacotherapy requires
specialized consultations with interdisciplinary collaborations.
Development of a suitable manufacturing process for production of a bioactive recombinant equine chorionic gonadotropin (reCG) in CHO-K1 cells
Authors: Villarraza Javier , Antuña Sebastián , Tardivo Belén , Rodríguez María Celeste , Mussio Pablo , Cattaneo Luciano , Fontana Diego , Ceaglio Natalia , Prieto Claudio
Published: November 2020

Equine chorionic gonadotropin (eCG) is a heterodimeric glycoprotein
hormone produced by pregnant mares that has been used to improve
reproduction activity in different types of livestock. Several
strategies to produce the hormone in a recombinant way have been
reported; nevertheless, none approach has been able to produce a
recombinant eCG (reCG) with significant in vivo bioactivity or in
sufficient quantities for commercial purposes. For this reason, the only
current product available on the market consists of partially purified
preparations from serum of pregnant mares (PMSG). Herein, we describe a
highly efficient process based on third-generation lentiviral vectors as
delivery method for the production of reCG in suspension CHO-K1 cells,
with productivities above 20 IU.106 cell-1.d-1 and 70% purification
yields after one purification step. Importantly, reCG not only
demonstrated biological activity in bovine cattle but also this
bioactivity appeared to be higher than PMSG, since 140 IU of reCG were
needed to exert the same biologic effect in an ovulation synchronization
protocol compared to 400 IU of PMSG. The results obtained show that the
developed strategy represents an attractive option to produce reCG and
constitutes an auspicious alternative for the replacement of animals as
a source of PMSG.
ElNoury - Webster bundle: a pre-emptive surgical approach for the management of morbidly low or adherent placenta
Authors: Elnouri Amr , Webster Dr Sophia , Abdelhalim Diaa
Published: November 2020

Placenta accreta spectrum and placenta praevia are a significant cause
of obstetric haemorrhage, maternal morbidity and mortality worldwide. We
report a novel surgical technique, which pre-emptively and
prophylactically reduces intrapartum bleeding during caesarean sections
for these conditions and hence reducing the risk for a caesarean
hysterectomy. This technique is particularly useful in low resource
healthcare settings where interventional radiology is not readily
available and where the woman is keen on uterine preservation. In this
report we present the surgical and clinical outcomes of a case series of
16 patients on whom this technique was piloted demonstrating its
feasibility and safety.
Accounting for underlying complexities identifies simple hierarchy of trait‒environment relationships in Wisconsin forest understory communities
Authors: Rolhauser Andres , Waller Don , Tucker Caroline
Published: November 2020

Adaptive relationships between traits and the environment are often
inferred from observational data by regressing community-weighted mean
(CWM) traits on environmental gradients. However, trait‒environment
relationships are better understood as the outcome of trait‒abundance
and environment‒abundance relationships, and the interaction between
traits and the environment. Accounting for this functional structure and
for interrelationships among traits should improve our ability to
accurately describe general trait‒environment relationships. Using
forest understory communities in Wisconsin, we applied a generalized
mixed model (GLMM) incorporating this structure. We identified a simple
hierarchy of trait‒environment relationships dominated by a strong
positive effect of mean temperature on plant height. Compared to the
traditional CWM approach, the GLMM was more conservative in identifying
significant trait‒environment relationships, and also detected important
relationships that CWM regressions overlooked. This work highlights the
need to consider the complexity underlying trait‒environment
relationships in future analyses
The Molecular Epidemiology and Clinical Phylogenetics of Rhinoviruses among Paediatric Cases in Sydney, Australia.
Authors: Adam Dillon , Chen Xin , Scotch Matthew , MacIntyre C. Raina , Dwyer Dominic , Kok Jen
Published: November 2020

Background Rhinoviruses (RV) represent the most common aetiological
agent of all acute respiratory tract infections across all age groups
and a significant burden of disease among children. Recent studies have
shown that RV-A and RV-C species are associated with varying degrees of
disease severity and clinical symptoms. Methods In this study, we
uncovered potential associations between RV species and subtypes, and
clinical disease severity using a matched dataset of 52 RV isolates
sampled from children (<18 years) in Sydney, Australia between
2006 and 2009 using epidemiological and phylogenetic methods. Results We
found that RV-C was significantly more likely to be isolated from
paediatric cases under two years of age compared to RV-A, although no
significant differences in recorded symptoms were observed. Significant
phylogenetic-trait associations between age and the VP4/VP2 capsid
protein phylogeny suggests age-specific variations in infectivity among
subtypes might also be possible. Conclusions This study adds to the
growing body of epidemiological evidence concerning RV. Improving
surveillance and testing for RV, including routine whole genome
sequencing may improve our understanding of the varied diseashe outcomes
of RV species and subtypes. Future studies could aim to identify
specific genetic markers associated with age-specific infectivity of RV
which could inform treatment practices and public health surveillance of
RV.
"The dark side of the Moon": unknown negative genes in the positive RNA genomes of coronaviruses
Authors: Oleg Prof. Zhirnov , Zhirnov O P , Poyarkov S V
Published: November 2020

Coronavirus family has a single-stranded RNA genome encoding 25-30
proteins in different viruses by the mechanism of positive-sense
strategy. Extended open reading translation frames (genes) were found to
locate under a negative-sense polarity in all coronaviruses genomes.
These negative-sense genes varies in the range of 150-450 nt to encode
negative genes polypeptides (NGP) with mol. wt. 5-30 kDa. It implies
that coronaviruses besides positive genome strategy may have “a dark
side of the Moon” expressing genes and virions through the negative
strategy. It is noteworthy, that positive- and negative-sense genes
colocolized in the same RNA regions of coronavirus genome, so called
stacking genes.  Ambisense stacking of genes in coronavirus genomes
significantly increases virus diversity, genetic potential and extend
virus-host adaptation pathway possibilities.
Intraoperative heparin resistance, severe tricuspid valve regurgitation and acute right ventricular failure following large right atrial myxoma excision in a post corona virus disease -2019 patient -- A case report
Authors: Mahapatra Rudra , Misra Satyajeet , Sathia Siddhartha , Gupta Shradha , Elayat Anirudh , Barik Ramachandra
Published: November 2020

ABSTRACT INTRODUCTION Tricuspid valve regurgitation (TR) and severe
right ventricular (RV) systolic dysfunction may appear acutely after
right atrial (RA) myxoma excision. Covid-19 infection may have a role in
production of Heparin resistance. METHODS A case of post covid-19
infected RA myxoma was operated by surgical excision develop severe TR
and acute right ventricular systolic dysfunction postoperatively for
which Tricuspid valve ring annuloplasty was performed and RV was
supported on Cardiopulmonary bypass (CPB). RESULTS RV dysfunction did
not improve leading to cardiac arrest and death. Conclusion • Excision
of RA myxoma can unmask the severe TR and severe RV systolic dysfunction
not responsive to TV ring annuloplasty. • COVID-19 infection might have
a role in production of heparin resistance. KEY WORDS: Covid-19,
tricuspid annuloplasty, intraoperative heparin resistance, RV
Dysfunction, cardiopulmonary bypass.
Slovenski prognanici u Nezavisnoj Državi Hrvatskoj
Authors: Riman Barbara , Škiljan Filip
Published: November 2020

Problematika prognanoga slovenskog stanovništva s prostora koji je tijekom Drugoga svjetskog rata okupirao Treći Reich prisutna je u hrvatskoj, slovenskoj i srpskoj povijesti, ali je prije svega povezana s
iseljavanjem i progonom drugoga (u prvom redu srpskoga) etničkog stanovništva. Ta etapa slovenske povijesti u Hrvatskoj nije dovoljno poznata široj javnosti. Upravo stoga radom se želi upozoriti na veliki broj Slovenaca koji su Drugi svjetski rat preživjeli na prostoru Hrvatske i Bosne i Hercegovine, odnosno tadašnje Nezavisne Države Hrvatske, koja je imala drugačije granice od današnje Hrvatske i Bosne i
Hercegovine. U dosad objavljenim radovima o progonu slovenskoga stanovništva u Hrvatsku i Bosnu i Hercegovinu često se zaboravlja na dodatni kulturni šok koji su prognanici doživjeli. Osim opisa djelovanja
legalnih institucija koje su bile zadužene za skrb o prognanom slovenskom stanovništvu, u radu su predstavljeni pojedinačni slučajevi iz kojih je vidljiva teška situacija i problemi s kojima su se suočavali
stanovnici prognani iz slovenskih krajeva.
Romi u Hrvatskom primorju za vrijeme Drugoga svjetskog rata
Authors: Vojak Danijel , Brlić Ivan
Published: November 2020

Povijest romskoga stanovništva često je obilježena nasiljem, stradanjem i
progonima, posebice od njihova doseljavanja na europska područja nakon XII. stoljeća, a to traje, s manjim intenzitetom, sve do danas. Kontekst
takva položaja Roma u europskim državama jest u njihovu negativnom percipiranju kao besposličara i lijenčina, kriminalaca, otimača djece, špijuna i sl. Upravo su to razlozi nacističkoga pokušaja genocida nad njima za vrijeme Drugoga svjetskog rata. Sličan odnos prema Romima imale
su talijanske fašističke vlasti, a on se temeljio na rasnim zakonima. Talijanske vlasti imale su tijekom Drugoga svjetskog rata nadležnost i nad Hrvatskim primorjem te znatnim dijelom hrvatske istočnojadranske obale. Istraživanje u radu usmjereno je na analizu položaja romskoga stanovništva u Hrvatskom primorju, pri čemu će se posebice analizirati odnos ustaških i talijanskih vlasti prema Romima. U radu će se koristiti
dosad neobjavljena građa iz Državnoga arhiva u Rijeci te građa iz Hrvatskoga državnog arhiva, kao i relevantna literatura.
Music education as manipulation – a proposal for playing
Authors: Thorgersen Ketil
Published: November 2020

An important feature of music is its ability to affect people in unpredictable and deep ways. Music has therefore been used to oppress and (mis)lead people by dictatorships, religious leaders and supermarkets amongst others, and to help lure people into acting in ways that are beneficial for the manipulators. Such forms of ethically dubious musical manipulation happen because of the sublime potential of music to do something to people, and in such a way that they have few ways to defend themselves against it. Thus, the power of music is also the reason people seek out the unforeseen affects and effects in their encounters with the arts. Building on a theory of aesthetic communication, and seeking support from Deleuze and Guattari (1994), Dewey (2005) and Spinoza (Spinoza & Lagerberg, 2001), the aim of this article is to propose the term manipulation as a tool in music education or as a vehicle for teachers and researchers to help frame activities in music education as meaningful for aesthetic communication.  I argue that manipulation is a necessary component of all art and aesthetic communication, that, despite its usual negative connotations, manipulation is an act that can be used for good or bad purposes, and that music education has a duty to educate pupils in artistic manipulation. Manipulation is considered action, and as such, it is argued that it can take on any value from good to bad depending on the intentions and effects it causes. This article invites a discussion of possible ways of designing music education that revolve around tinkering with aesthetic communication, and wherein desirable manipulation plays a vital role, and outcomes-based curricula are replaced with an alternative more compatible with the arts.
Developing reflection-in-musicking in creative practices
Authors: Viig Tine Grieg
Published: November 2020

This article examines the development of reflection-in-musicking in a Write an Opera project at a Norwegian upper secondary school. As part of a PhD project, this case study focuses on a group of seven participants collaborating to create music for an opera with a professional composer facilitating the process. Interviews, observations and video-recordings make up the body of the empirical material. Theories of musicking (Small 1998) and reflection-in-action (Schön, 1983, 1987), and a sociocultural perspective, have been central to understanding the creative practices examined in this study. Learning features found build on socially and culturally co-constructed repertoires of experience, knowledge and skills. Three modes of reflection-in-musicking are identified from the empirical data: aesthetic, artistic and structural.
Improvisation i musikundervisningen: Tre lärares didaktiska förhållningssätt
Authors: Larsson Christina , Georgii-Hemming Eva
Published: November 2020

This article draws on interviews with three music teachers. It is part of a larger study that explores improvisation in general music education in the Swedish school year 4. The article focuses teachers’ pedagogical approaches to improvisation and how this effect the teaching. This study reveals that music teachers incorporate improvisation in their teaching. They do, however, lack a professional language in order to reflect on content, methods, aim and purpose of improvisation in education. Through thematic analysis, we demonstrate that pedagogical points of departure and attitudes are implicitly present in the teachers’ practices and have implications for their educational orientation. Three diverse but overlapping educational orientations are discerned: a process-oriented, a subject-oriented and a Bildung-oriented. The educational orientations are reflected in these teachers’ approaches to improvisation and are related to pedagogical choices of activities, how activities are conducted and to what aim.
Music teachers’ perspectives on their chances to disrupt cultural and social reproduction in the Swedish Community Schools of Music and Arts
Authors: Jeppsson Cecilia
Published: November 2020

This study sheds light on music teachers’ perspectives on their chances to disrupt cultural and social reproduction in music education in the Swedish Community Schools of Music and Arts (kulturskolor, sing. kulturskola). Focus group conversations were carried out involving 18 teachers at five such schools. As a point of departure, the analysis of the conversations applied the theoretical perspective of Bourdieu with an emphasis on the concepts explicit versus implicit pedagogy and Bernstein’s corresponding concepts visible and invisible pedagogy. The analysis discusses explicit versus implicit assumptions interwoven in the teachers’ accounts of their efforts. The teachers describe it as difficult to challenge social structures. Based on marketing efforts vis-á-vis families from immigrant backgrounds, the teachers point to differing understandings of the significance of participation in the programmes. The teachers’ descriptions point to opportunities that stem from efforts to facilitate children taking part in music education in cooperation with compulsory schools, teaching practice habits and more general behaviours, and initiatives to reach parents and children from immigrant backgrounds with information. The descriptions show explicit as well as implicit components, often in terms of implicit assumptions embedded in an explicit framing. Reflection upon implicit assumptions is suggested as a means to develop more radical strategies to disrupt cultural and social reproduction in the Swedish kulturskolor.
The philosophical fiber: Rethinking ensemble conducting in light of a record producer’s practice
Authors: Øien Ola Buan
Published: November 2020

The overall aim of this single case study is to find aspects of musical leadership relevant to ensemble conducting, using the theory of practice architectures to analyze a record producer’s practice. Data generation is performed mainly through transcripts and reflection logs based on YouTube interviews and videos. Insights into ensemble conducting are offered by exploring the following question: “What aspects of musical leadership relevant to conducting can be identified by applying the theory of practice architectures to an analysis of record producer Daniel Lanois’s practice?” The materials are analyzed based on three contexts of interpretation of meaning in hermeneutics. The theory of practice architectures serves as the analytical lens for the third context of interpretation. Main findings from this study are extracted into nine concepts that may serve as aspects of musical leadership relevant to conducting: a fast communication system, a self-adjusting act, black dubs, locations, operating by limitation, master station, the philosophical fiber, preparing, and sonic ambience. These and similar concepts may offer new insights into ensemble conducting in contexts similar to recording situations.
Preliminary Data of Bioresonant Impact on the Growth and Morphology of Candida guillermondi after Storage in Culture Collection
Authors: K Ganbarov
Published: November 2020

Bioresonant effect is the correction of body functions when exposed to electromagnetic fields strictly defined parameters. Impact is possible both on the cellular and at the level of the whole organism. The basic idea of using bioresonance is that with the proper selection of electromagnetic radiation, normal and weakening pathological changes in the body can be enhanced. The purpose of this work is to study the shape, size and growth of the yest culture stored in the collection after bioresonant impact. Th e culture of the yeast Candida guillermondi BDU - 217, stored in the culture collection of the Department of Microbiology, Baku State University, was taken as an object for one year on the wort agar medium at a temperature of 4 - 6  C. After influence of electr omagnetic fields to the cells, stored for one year, appeared colonies with signs of the initial culture. Moreover, with direct biorezonant impact the size of some colonies became much larger than the initial. And with impact simultaneous direct and inverse electromagnetic radiation, it gave results similar to both the initial and stored for one year culture. It has been shown that, regardless of the form of bioresonant impact (direct or inverted), the shape and size of the cells of the yeast culture can be restored and even modified, i.e. from ovoid to rod - shaped. These preliminary data provide prerequisites for the recognition of a new scientific approach in restoring the changed properties of microorganisms using bioenergy information transfer. Experiments according to research are continued.
Microbiological Analysis of Pharmaceutical Non Injectable Drugs Produced in Dhaka, Bangladesh
Authors: T Ahmed
Published: November 2020

Pharmaceutical drugs are applied and consumed by the patients with weak immune system and for this reason these products must be of good quality and within the required microbiological limit. Present study attempted to determine the microbiological quality of pharmaceutical non injectable oral and topical drugs as well as their antibacterial activity. A total of sixty samples were studied from different categories of medicine including syrup, tablet & capsule and ointments. Microbiological analysis was done after serial dilution. Antibacterial activity of the samples was also determined by Kirby-Bauer method. The total viable bacterial count of 9 syrups, 7 tablet & capsules and 13 ointments samples exceeded the microbial limit ˂102cfu/ml or cfu/gm recommended by USP (United States Pharmacopeia) and BP (British Pharmacopeia). Regarding to the presence of specific bacteria, about six, six and three samples from syrup, tablet & capsule and ointment samples were of good quality respectively out of twenty samples each. Some drug prevailed good activity towards few bacteria and no activity at all to some others. As the drugs possess antibacterial activity, the contaminants might represent some other species of the same genera of bacteria having some mechanisms to prohibit such activities towards them. More than 50% of the drugs contain higher bacterial and fungal load rendering the quality at risk and not recommended to use by the patients to whom these products will impart most harm as these patients are already immune compromised.
T Cells, Endothelial Cell, Metabolism; A Therapeutic Target in Chronic Inflammation
Authors: CPK Cheung
Published: November 2020

The role of metabolic reprogramming in the coordination of the immune response has gained increasing consideration in recent years. Indeed, it has become clear that changes in the metabolic status of immune cells can alter their functional properties. During inflammation, stimulated immune cells need to generate sufficient energy and biomolecules to support growth, proliferation and effector functions, including migration, cytotoxicity and production of cytokines. Thus, immune cells switch from oxidative phosphorylation to aerobic glycolysis, increasing their glucose uptake. A similar metabolic reprogramming has been described in endothelial cells which have the ability to interact with and modulate the function of immune cells and vice versa. Nonetheless, this complicated interplay between local environment, endothelial and immune cells metabolism, and immune functions remains incompletely understood. We analyze the metabolic reprogramming of endothelial and T cells during inflammation and we highlight some key components of this metabolic switch that can lead to the development of new therapeutics in chronic inflammatory disease.
The Effectiveness Use of Virtual Reality Media in Physics Education of Solar System Towards Cognitive Learning Outcomes
Authors: Saputro Sigit Dwi , Setyawan Agung
Published: November 2020

Digital literacy skills in the context of mastering the use of digital media were needed to streamline achievements in learning. One of the digital medias that can be applied in abstract learning is virtual reality. The purpose of this research was to determine the effectiveness of cognitive learning outcomes which include the presence or absence of the influence of the use of virtual reality media, the completeness of learning outcomes based on KKM and the completeness of classical learning outcomes. This type of research was pre-experimental by using one group pre-test post-test design. The sample used was class VIII Al-Asyari Technology Middle School which consists cof only one class. The instruments used in the study include description tests. The effect of learning outcomes was analyzed by t-test using SPSS, learning outcomes will be analyzed based on the Minimum Completion Criteria (KKM) and classical completeness while learning motivation was analyzed quantitatively. The results showed that physics learning using effective virtual reality media on learning outcomes as evidenced by the influence of virtual reality media on results with a significance of 0.000, learning outcomes reached the KKM value of 75 with an average yield of 88.1. Classical learning completeness obtained a percentage of results of 86.3% included in the excellent category.
EM DEFESA DA EDUCAÇÃO INCLUSIVA
Authors: Antunes Mitsuko Aparecida Makino , Santos Ruzia Chaouchar dos , Magalhães Luciana de Oliveira Rocha
Published: November 2020

Editorial
PROMOÇÃO E PREVENÇÃO EM SAÚDE MENTAL NA INFÂNCIA: IMPLICAÇÕES EDUCACIONAIS
Authors: Faria Nicole Costa , Rodrigues Marisa Cosenza
Published: November 2020

Nos últimos anos, um novo paradigma em saúde mental vem se consolidando, impulsionado por novas formas de compreender e intervir sobre os processos de saúde. Uma perspectiva mais abrangente, contextualizada e focada nos processos de saúde ganha força, em detrimento de uma abordagem reducionista, institucionalizante e que enfatizava a doença. Nesse contexto, as práticas de promoção e prevenção em saúde mental ganham espaço, as quais objetivam potencializar a saúde psicológica e evitar o surgimento de problemas a ela associados. Assim, este trabalho pretendeu discutir quais as implicações educacionais deste novo paradigma no que diz respeito à saúde mental de crianças e adolescentes. Inicialmente, traça-se um histórico da atenção à saúde mental infantil no Brasil, evidenciando um longo período de descaso e marginalização em relação a essa população. Posteriormente, são discutidos os pressupostos que fundamentam as ações de promoção e prevenção em saúde mental e o papel da escola nesses processos. Finalmente, são discutidos alguns estudos de revisão sobre a implementação de programas de prevenção e promoção em contexto escolar. Acredita-se que a construção de estratégias destinadas à promoção de saúde mental configura-se como um desafio atual, sobretudo, no contexto educacional.
THEATER OF THE EARLY MODERN PERIOD: BETWEEN “SCHOOL” AND “CITY”
Authors: Лурье Зинаида Андреевна
Published: November 2020

В статье на материале позднесредневековой Германии рассматривается место театра как коммуникативного канала в городском пространстве. Автор исходит из представления о том, что в диалоге между властью и городской общиной важнейшую роль играли паратеатральные практики (процессии, различные игры и пр.), тогда как собственно спектакли начиная с первых десятилетий XV в. были каналом внутригородской коммуникации. К производству спектаклей имели доступ разные сословия, что обуславливало в целом нейтральный характер театральных текстов, выполняющих главным образом консервативную и развлекательную функции. Изменилась ли роль театра в связи с развитием гуманизма и с институциализацией театра внутри школьной системы в раннее Новое время? В статье предпринята попытка ответить на этот вопрос на материале творчества раннего протестантского литератора Сикста Бирка. В историографии его творчество рассматривается через призму политического измерения, а сам он – как весьма рафинированный, интеллектуальный литератор. Однако, как считает автор статьи, тексты Бирка мало отличаются от позднесредневековой традиции. Анализ показывает, что Бирк утверждает все те же ценности стабильности и транслируют прежние топосы. Однако «Школа» явно подталкивает «Город» к осмыслению социального опыта.

The article, based on the material of late medieval Germany, examines the place of the theater as a communicative channel in urban space. The author proceeds from the idea that paratheatre (processions, various games, etc.) played an important role in the dialogue between the authorities and the city community, whereas performances themselves, starting from the first decades of the 15th century, were a channel of intercity communication. Different classes had access to the production of performances, which led to the generally neutral nature of theatrical texts that performed mainly conservative and entertaining functions. Has the role of the theater changed in connection with the development of humanism and institutionalization of the theater within the school system in the Early Modern Period? The article attempts to answer this question on the material of the works of the early Protestant writer Sixt Birck. In historiography, his works are viewed through the prism of the political dimension, and he is classified as a very refined, intellectual writer. However, according to the author of the article, Birck’s texts differ little from the late medieval tradition. The analysis shows that Birck maintains the same values of stability and medieval topoi. However, the "School" clearly pushes the "City" to comprehend social experience.
Lichen Planus - A Clinicopathological Correlation from a Tertiary Care Institute in Chhattisagrh
Authors: Agarwala Manoj Kumar , Agarwala Pragya , Chandrakar Karan
Published: November 2020

Background: Lichen planus is a mucocutaneous disorder of unknown aetiology with mucosal involvement seen in 30-70% of cases. Histopathology is a reliable tool to diagnose lichen planus and differentiate it from other lichenoid eruptions. Methodology: 103 patients aged ≥18 years consecutively attending the outpatient clinic with clinical features suggestive of cutaneous and/or oral LP were recruited. A detailed data collection proforma including the demographic details was filled and clinical examination was done. The diagnosis of LP was confirmed by biopsy. An attempt to study the clinico-pathological correlation was made. Results: We studied 103 patients of lichen planus with ages ranging from 18- 77 years with the mean age being 45.8 years. In males, the peak prevalence was between the ages of 35-44 years while in the females, it was in the range of 45-54 years. There was no gender predilection in our study. Conclusion: Hypertrophic and classical types of CLP, and reticular and erosive types of OLP were common patterns in our study population. There was agreement between the clinician and the pathologist in 85% of cases.
Family Support in Victims of Children of Sexual Violence in Indonesia
Authors: Februanti Sofia , Kartilah Tetet
Published: November 2020

Every child has the right to survival, to grow and develop and has the right to protection from violence and discrimination. However, there are still many problems faced today, especially in Indonesia.This study aims to determine family support for girls who are victims of sexual violence. This study uses qualitative research methods with an in-depth interview approach with audio recordings, field notes, documentation. Participants in this study were families who had family members/girls victims of sexual violence. Sampling using purposive sampling technique that fits the inclusion criteria. The interview was recorded and made the word for word transcription. Transcripts of interviews were analyzed by Colaizzi's steps. The results of the study showed that there were four themes namely family informational support, family assessment support, family instrumental support, family emotional support. Family support is needed by girls who are victims of sexual violence to help their future survival.
Carpal Tunnel Syndrome as an Unusual Immune Checkpoint Inhibitor Adverse Effect: A Case Series and Review of the Literature
Authors: Shalata Walid , Yakobson Alexander , Massalha Ismaell , Grinberg Roxana D. , Goldstein Iris M. , Gibbs Rachel , Grinberg Roy , Neime Ala Eddin , Abu-Juma'a Ali , Kian Waleed , Peled Nir , Rouvinov Keren
Published: November 2020

While immune checkpoint inhibitors (ICIs) have transformed standards of care and drastically improved patient prognoses in several malignant diseases, a range of immune related adverse events (irAEs) from ICIs have been observed. This case series describes the clinical course of three patients with unusual immune checkpoint-inhibitor (ICI) induced toxicities. These three patients developed carpal tunnel syndrome (CTS) while on ICI therapy. The first patient was a 79 year-old male who received neo-adjuvant chemo-immunotherapy and adjuvant immunotherapy (atezolizumab) for stage II-B lung adenocarcinoma, the second patient was a 70 year-old female who received immunotherapy only (nivolumab) for stage IV renal cell carcinoma and the third patient was a 71 year-old male who received adjuvant immunotherapy (nivolumab) for stage 2-A melanoma. The patients developed carpal tunnel syndrome with severe neuropathy as a result of therapy. All patients had complete symptomatic relief when treated with either corticosteroids or intravenous immunoglobulins for CTS.
Unusual Adverse Effects of Immune Checkpoint Inhibitors: Autonomic Neuropathy, Palmoplantar Keratoderma, Reiter Syndrome & Myasthenia Gravis: A Case Series and Review of the Literature
Authors: Shalata Walid , Yakobson Alexander , Massalha Ismaell , Y. Cohen Aharon , Goldstein Iris M. , Gibbs Rachel , Omar Abu Saleh , Asla Mohnnad , Dudnik Yulia , Abu-Juma'a Ali , Peled Nir , Rouvinov Keren
Published: November 2020

The immune checkpoint inhibitors (ICIs) have transformed the standards of care in cancer treatment and has dramatically improved patient prognoses. As a result of the introduction of these novel treatments several types of adverse events related to ICIs (immune related adverse events ((irAEs)) have been observed and reported. In this case series we describe the clinical course of four patients, with unusual ICI induced toxicities. The first patient was a 59 year-old female who received chemo-immunotherapy (pembrolizumab) for stage 4- lung adenocarcinoma, and developed autonomic neuropathy (AN). The second and third patients were both 63 year-old males who also received chemo-immunotherapy (pembrolizumab) for stage 4-A lung adenocarcinoma. One of those patients developed palmoplantar keratoderma and one developed conjunctivitis, urethritis and arthritis (Reiter syndrome). The fourth patient was an 80 year-old male who received chemo-immunotherapy (pembrolizumab) for stage 3-A squamous cell carcinoma of the lung and developed myasthenia gravis.
An inquiry into the Milan tribe with an introduction to nomadism in Iran
Authors: Hoseinpour Bagher , Kalaycioglu Sibel
Published: November 2020

Iran with its unique geographically most suitable for animal husbandry and has always been a home for myriad of tribes who have played a significant role in its socio-political history. Milan, among the many, is one of the largest nomadic Kurdish tribes in West Azarbaijan province, about which no information except for few is available. Applying qualitative method and semi-in-depth structural interviews and reviewing historical documents, we examined the historical roots of Milan and its socio-economic life in Iran. The findings show that Milan is originally a large Kurdish confederacy in northern parts of Iraq that was forced to move to Turkish borders with Iran during the Ottoman period to counter the Safavid regime's attacks. Due to fertility of lands, Milan resided there forever and then after, some branches migrated to Iran and settled down in its northwestern parts.
Of Kings and Cobots
Authors: Cleave Peter
Published: November 2020

In the previous paper and video presentation a consideration of Amazon as a market place of some authority was made. The primary source there and in the course of this series is Brian Dumaine’s book Bezonomics (Dumaine 2020). I want to acknowledge that influence especially for matters of fact here. In this series I have put my own construction on an extremely good compilation of detail on Amazon by Dumaine. Other figures are cited when the source is not Dumaine.
Analysis of College Students’ Cybersecurity Awareness In Indonesia
Authors: Chasanah Balqis Rofiqoh , Candiwan Candiwan
Published: November 2020

Internet-based attacks have become common and are expected to happen continuously with the development of technology. Therefore, cybersecurity emerged as an important concept in everyday life. It is defined as the protection of cyberspace. Cybersecurity Awareness (CSA) exists as a major defense key in protecting users and systems from internet-based attacks. The research presented in this study aims to assess the level of CSA among college students in Indonesia. This study uses the Analytic Hierarchy Process (AHP) method to test students in three dimensions, including attitudes, knowledge, and behavior. To measure this dimension, six focus areas in the topic of cybersecurity were taken and developed from previous studies on the same topic. The six focus areas are password security, cyberbullying, phishing, malware, identity theft, and the last is downloading, sharing and use of pirated content. The results showed that the total level of CSA for college students in Indonesia was in the good criteria. This is indicated by a total percentage of awareness around 80%. Nevertheless there are some focus areas that can be improved to increase the percentage.
Improving the management of business ecosystems of the border territory (using the example of Russia and China)
Authors: Sharipov F. F. , Timofeev O. A.
Published: November 2020

The unique geographical location of our State can be used to develop Russian-Chinese business ecosystem on the border territories. On the basis of the analysis, the authors in their study determine ways to improve the management of the business ecosystems of the border area between Russia and China.
The role of innovation potential in gaining competitive advantage in industrial companies
Authors: Almrshed Sattar Kadim Hachim
Published: November 2020

In today’s highly dynamic business environment, it is crucial to the growth and prosperity of a company to gain and retain a competitive advantage. Organizations need to develop unique competitive advantages to keep pace with the pace of change in technology and customer requirements. In this difficult task, organizations can benefit from innovation strategies and tools more than ever before, as they help companies improve their position in the market by increasing their performance and efficiency, and one of the strategically effective ways is to develop the innovative capabilities of a company. Our aim in this study is to clarify the role of innovative capabilities strategies in improving the performance of the organization and achieving a competitive advantage in the market. This article provides an up–to–date review of the existing literature in the field of innovation and innovative potential in order to identify the potential consequences of industrial firms gaining innovative capacity and their role in gaining a competitive advantage. This study will help managers and practitioners to understand the role of innovation management tools in gaining a competitive advantage through strategies for successfully assessing innovation potential.
What components should an ethics and compliance program consist of to help organizations remain ethical and compliant in times of crisis and beyond?
Authors: Skalska A.
Published: November 2020

Organizations currently face many challenges due to the COVID–19 pandemic. In similar times of crisis, it is of the utmost importance for organizations to remain ethical and compliant with the law as well as with the temporary measures imposed on them by States. Ethics and compliance programs help organizations behave ethically and in compliance with all rules in a structured and comprehensive way. The paper analyzes selected models of an ethics and/or compliance program with the aim to find out what components an ethics and compliance program should contain in order to be effective in ensuring ethical and compliant behavior of an organization at all times including unexpected crises.
The influence of classical philosophy on the transformation of economics and economic institutions
Authors: Ryazanova G.
Published: November 2020

The author reveals the connection between philosophical and economic thoughtin the classical period. The influence of philosophy on political and economic aspects ofnational economy development in the pre–scientific and scientific periods is revealed. Thefeatures of philosophical and worldview concepts of classicism that reflect the specifics of theera are indicated. The analysis of the relationship between classical philosophy and Economicshas shown the influence of spiritual and moral aspects of the epoch, transcendentalism,rationalism, and a apriorism on economic theories based on the mechanistic paradigm, thelogic of economic laws, and clear and unambiguous provisions for the formation anddevelopment of economic institutions. A model is presented that reveals the interaction ofeconomic institutions from the position of classical philosophy in terms of the individualisticconcept of behavior of classical economic agents, the Institute of labor resources as the basis ofvalue and wealth, balance as a key element of the self–regulating order and distribution ofeconomic benefits, and other aspects.
Current State of the Russian Financial Derivatives Market
Authors: Petrova A. A.
Published: November 2020

The article considers the structure and the quantitative characteristics of the Russian derivatives market. The main research method is the analysis of the dynamics of the statistical data of the Moscow Exchange. The study identified the features of the Russian derivatives market. The influence of the beginning of the crisis 2020 on the derivatives market is shown.
Capacidade de resposta dos Órgãos Públicos aos acidentes ocorridos no transporte rodoviário de produtos químicos na cidade de São Paulo
Authors: Hadad Edson , Kniess Cláudia Terezinha , Ruiz Mauro Silva , Teixeira Claudia Echevengua
Published: November 2020

O estado de São Paulo possui uma intensa movimentação rodoviária de produtos químicos, situação preocupante devido aos perigos intrínsecos ao transporte desses materiais e aos riscos de acidentes em uma cidade de elevado adensamento populacional. A capacidade de resposta dos órgãos públicos, ou seja, a capacidade de minimizar os impactos à saúde e segurança pública e ao meio ambiente, também interfere na magnitude das consequências dos acidentes. Nesse contexto, este artigo objetiva avaliar como se configura o atual cenário de atendimento a emergências no transporte rodoviário de produtos químicos na cidade de São Paulo, na perspectiva dos órgãos públicos envolvidos. Para tanto, foi realizado um estudo de caso, o qual envolveu a simulação, em modelo matemático, de um acidente rodoviário com cloro. Foram plotadas na cidade de São Paulo as distâncias atingidas pela nuvem tóxica e estimados o número de vítimas fatais e intoxicadas pelo produto. Por meio de entrevistas, os resultados foram apresentados a especialistas de cinco órgãos públicos para que avaliassem a capacidade de resposta da instituição frente ao cenário simulado. Com base nas simulações, entrevistas e documentação levantada foi realizada a análise para consolidar a atual capacidade de resposta da cidade de São Paulo, tendo sido identificadas diversas fragilidades para o atendimento emergencial.
Methotrexate in rheumatology – efficacy and safety of the therapy
Authors: Kosakowski Tomasz
Published: November 2020

Methotrexate is currently the safe and effective drug used in chronic arthritis and other rheumatic diseases. Avoiding the use of methotrexate in everyday rheumatic treatment can lead to significant health complications. There is no time frame for the use of methotrexate, the drug can be used successfully for many years. The therapeutic dose of the drug is usually 25–30 mg/week. The most common side effects are gastrointestinal disorders and elevated transaminase levels. The efficacy and safety of methotrexate have been confirmed in many clinical trials and in everyday clinical practice.
From suspicion of angioedema to the diagnosis of lung cancer
Authors: Moos Łukasz , Żurek Wojciech , Kapeluszna Katarzyna , Brzoza Zenon
Published: November 2020

Angioedema is a localized and self-limiting oedema of the subcutaneous and submucosal tissue. Case presentation: 73-year-old man was admitted to the Division of Allergology with the diagnosis of angioedema. Detailed physical examination led to the suspicion of superior vena cava syndrome with secondary face swelling. Biopsy revealed metastasis of small cell carcinoma in superclavicular lymph nodes. Conclusions: Facial swelling, especially recurrent and non-inflammatory, is often, but not always caused by angioedema. Insightful differential diagnosis is crucial before making the final one.
Prognosis of paradoxical low-flow low-gradient aortic stenosis after transcatheter aortic valve replacement
Authors: Saito Yukihiro , Lewis Erik E. , Raval Amish , Gimelli Giorgio , Jacobson Kurt , Osaki Satoru
Published: November 2020

Aims

In paradoxical low-flow low-gradient severe aortic stenosis (PLFLG AS) patients, stroke volume index (SVI) is reduced despite preserved left ventricular ejection fraction (LVEF). Although reduced SVI is already known as a poor prognostic predictor, the outcomes of PLFLG AS patients after transcatheter aortic valve replacement (TAVR) have not been clearly defined. We retrospectively investigated the post-TAVR outcomes of PLFLG AS patients in comparison with normal-flow high-gradient aortic stenosis (NFHG AS) patients.

Methods

The current observational study included 245 patients with NFHG AS (mean transaortic pressure gradient ≥40 mmHg and LVEF ≥ 50%) and 48 patients with PLFLG AS (mean transaortic pressure gradient <40 mmHg, LVEF ≥ 50% and SVI < 35 ml/m2). The endpoints were all-cause mortality, hospitalization for valve-related symptoms or worsening congestive heart failure and New York Heart Association functional class III or IV.

Results

PLFLG AS patients had a significantly higher proportion with a history of atrial fibrillation/flutter as compared with NFHG AS patients. All-cause mortality of PLFLG AS patients was worse than that of NFHG AS patients (P = 0.047). Hospitalization for valve-related symptoms or worsening congestive heart failure was more frequent in PLFLG AS patients than in NFHG AS patients (P = 0.041). New York Heart Association functional class III–IV after TAVR was more frequently observed in PLFLG AS patients (P = 0.019).

Conclusion

The outcomes of PLFLG AS patients were worse than those of NFHG AS patients in this study. Preexisting atrial fibrillation/flutter was frequent in PLFLG AS patients, and may affect their post-TAVR outcomes. Therefore, closer post-TAVR follow-up should be considered for these patients.
Review of updated regulations and product license categories for veterinary vaccines in the United States
Authors: Erdman Matthew M. , Clough Nancy E. , Hauer Paul J.
Published: November 2020

The USDA continues to consider and implement regulatory pathways for evolving scenarios, needs, and technologies. The intent of this report is to make veterinarians and other users of veterinary biologics aware of recent regulatory additions and changes, particularly in the area of veterinary vaccines. These include new licensure pathways to increase product availability, standardization of labeling, and increased transparency regarding adverse event reports and the efficacy and safety studies accepted by the USDA for product licensure. This report did not undergo scientific peer review.