bluuebunny/crossref_metadata_2025 huggingface dataset:
Tidying up the conformational ensemble of a disordered peptide by computational prediction of spectroscopic fingerprints
Authors: Michaelis Monika , Cupellini Lorenzo , Mensch Carl , Perry Carole C. , Delle Piane Massimo , Colombi Ciacchi Lucio
Published: August 2022

The most advanced structure prediction methods are powerless in exploring the conformational ensemble of disordered peptides and proteins and for this reason the "protein folding problem" remains unsolved. We present a novel methodology that enables the accurate prediction of spectroscopic fingerprints (Circular Dichroism, Infrared, Raman, and Raman Optical Activity), and by this allows for "tidying up" the conformational ensembles of disordered peptides and disordered regions in proteins. This concept is elaborated for and applied to a dodecapeptide, whose spectroscopic fingerprint is measured and theoretically predicted by means of enhanced-sampling Molecular Dynamics coupled with Quantum Mechanical calculations. Following this approach, we demonstrate that peptides lacking a clear propensity for ordered secondary-structure motifs are not randomly, but only conditionally disordered. This means that their conformational landscape, or phase-space, can be well represented by a basis-set of conformers including about 10 to 100 structures. The implications of this finding have profound consequences both for the interpretation of experimental electronic and vibrational spectral features of peptides in solution and for the theoretical prediction of these features using accurate and computationally expensive techniques. The here-derived methods and conclusions are expected to fundamentally impact the rationalization of so-far elusive structure-spectra relationships for disordered peptides and proteins, towards improved and versatile structure prediction methods.
Evolving Drug Design Methodology: from QSAR to AIDD
Authors: Xu Jun
Published: August 2022

When medicinal chemistry was born a hundred years ago, a drug design methodology was expected to be based on the knowledge of the relations among chemistry, biology and medicine. Originally, chemists believed that a drug molecule consists of a scaffold with several substituents. While the substituents were replaced by alternate functional groups (aka substructures), the activity value of the molecule would be changed accordingly. This is termed as structure–activity relationship (SAR), which can be used to guide chemists to chemically modify the molecule to improve its druggability. Along with the progress of computing technology, SAR evolved into QSAR (Quantitative SAR). QSAR method prevailed in the era when determinism dominated the scientific community. Therefore, the paradigm of QSAR studies was based on the thought of “discovering the analytical rules (analytical formula of functional) between independent variables and functions hidden in experimental data by curve fitting or regression”. Earlier QSAR was based upon so called the similarity and additivity postulates. With the advent of the era of high-throughput experiments and big data, the two postulates are facing serious challenges. Coupled with the puzzling problems (such as substructure partitioning, “activity cliff”, unbalanced data sampling, and the paradox of prediction accuracy and generalization), conventional QSAR was declining from mature. In the beginning of this century, artificial intelligence (AI), specifically deep learning (DL), significantly succussed in image pattern recognition and natural language processing (NPL). AI was soon adopted for QSAR studies as a disruptive approach. It is now believed that drug design can be data-driven instead of rule-based (curve-fitting or regression). QSAR can also be directly revealed by AI without knowing the mechanisms of actions. Thus, the two postulates of conventional QSAR are no longer required, and the associated puzzling problems or paradoxes could be resolved. By examining the historical pathway of QSAR evolving into AI assisted drug design (AIDD), this review summarizes the process how the drug design paradigm is transformed from determinism to causalitism + probabilitism. The principles and challenges of drug design methodology are explored, the pros and cons for QSAR and AIDD are discussed with perspectives. It is worth noting that although AIDD is powerful, it is not omnipotent and should be treated rationally. The essence of machine learning is to reveal the major trends of a data set; while the minor trends (aka outliers, which are often ignored or discarded) cannot be captured by AI algorithms. However, the outliers are likely to be the entrances to disruptive discoveries. Therefore, philosophically, it is unrealistic to develop innovative drugs only relying on AIDD. AIDD’s achievements rely on inheriting the legacy of QSAR's theories, methods, technologies, and data.
A Universal Concept for Bright, Organic Solid State Emitters - Doping of Small Molecule Ionic Isolation Lattices with FRET Acceptors
Authors: Kacenauskaite Laura , Stenspil Stine G. , Olsson Andrew H. , Flood Amar H. , Laursen Bo W.
Published: August 2022

Brightly fluorescent solid-state materials are highly desirable tools in bioimaging, optoelectronic applications and energy harvesting. However, close contact between π-systems leads to strong electronic coupling and often subse-quent quenching of the emitters in dense solid-state materials. Recently, we developed a method to prohibit strong coupling based on small molecule ionic isolation lattices (SMILES) that efficiently isolate fluorophores while in paral-lel ensuring very high densities of the dyes. Nevertheless, efficient FRET energy migration in such dense systems is inevitable. While attractive for energy harvesting applications, FRET also significantly compromises quantum yields of fluorescent solids by funneling excitation energy to dark trap states like crystal defects. Here we investigate the underlying property of FRET and exploit it to our favor by intentionally introducing fluorescent dopants into SMILES materials, acting as FRET acceptors with favorable photophysical properties. This doping is shown to outcompete en-ergy migration to dark trap states, while also ruling out reabsorption effects in dense SMILES materials, resulting in universal fluorescent solid state materials (thin films, powders, crystals) with superior properties. These include emission quantum yields reaching as high as 50-65 %, programmable fluorescence lifetimes with mono-exponential decay, and independent selection of absorption and emission maxima. The volume normalized brightness of these FRET-based SMILES now reach values up to 32200 M-1 cm-1 nm-3 and can deliver freely tunable spectroscopic properties for the fabrication of super bright advanced optical materials.
Chemoinformatics and Artificial Intelligence Colloquium: Progress and Challenges to Develop Bioactive Compounds
Authors: Bajorath Jürgen , Chávez-Hernández Ana L. , Duran-Frigola Miquel , Fernández-de Gortari Eli , Gasteiger Johann , López-López Edgar , Maggiora Gerald M. , Medina-Franco José L. , Méndez-Lucio Oscar , Mestres Jordi , Miranda-Quintana Ramón Alain , Oprea Tudor I. , Plisson Fabien , Prieto-Martínez Fernando D. , Rodríguez-Pérez Raquel , Rondón-Villarreal Paola , Saldívar-Gonzalez Fernanda I. , Sánchez-Cruz Norberto , Valli Marilia
Published: August 2022

We report the main conclusions of the first Chemoinformatics and Artificial Intelligence Colloquium, Mexico City, June 15-17, 2022. Fifteen lectures were presented during a virtual public event with speakers from industry, academia, and non-for-profit organizations. Twelve hundred and ninety students and academics from more than 60 countries. During the meeting, applications, challenges, and opportunities in drug discovery, de novo drug design, ADME-Tox (absorption, distribution, metabolism, excretion and toxicity) property predictions, organic chemistry, peptides, and antibiotic resistance were discussed. The program along with the recordings of all sessions are freely available at https://www.difacquim.com/english/events/2022-colloquium/
What is the maximum charge uptake of Lindqvist-type polyoxovanadates in organic-inorganic heterostructures?
Authors: Sorokina Anastasia , Rydnyk Dmitry A. , Monakhov Kirill Yu. , Heine Thomas
Published: August 2022

One of the striking characteristics of the tris(alkoxo)-ligated Lindqvist-type polyoxovanadates [VV6O13{(OCH2)3CR}2]2– in highest oxidation state in solution is the ease of their chemical post-functionalization via the R group. On surfaces it is their conductivity as a function of individual V(3d) redox states. In both cases, the structural stability of the fully-oxidized dianion is enabled by charge-balancing counterions. In this Article, we explore the charge stability and the charge distibution across the molecular Lindqvist-type hexavanadate structure regarding the R functionality (R = OC2H4N3, CH2N3, and O3C29H36N5) and the different type of countercations (Cat = K+, Li+, NH4+, H+, or Mg2+). We show that the hexavanadate core can accept in its vacant V(3d) orbitals at least four and, in some cases, up to nine additional electrons if the negative charge is offset by the corresponding cation(s), without electron leakage to the covalently attached R groups. Remarkably, the maximum number of accepted electrons strongly depends on the type of cation(s) and is independent on the type of the remote R group exploited herein. The (Cat)n[VV6O13{(OCH2)3CR}2] complexes exibit the structural integrity in all studied charged states. Our study demonstrates the importance of the countercations of multistate polyoxovanadate nanoswitches for the development of multi-charge based molecular memories and/or batteries.
Morphometry of the limb skeleton of the wild and domesticated american mink (Neovision vision): gender features and symmetry characteristics
Authors: Дикарев Станислав Вячеславович , Кораблев Николай Павлович , Кораблев Павел Николаевич
Published: August 2022

Проведен анализ индекса полового диморфизма и симметрии посткраниального скелета по 20 морфометрическим признакам американских норок (Neovison vison), населяющих дикую природу и содержащихся в зверохозяйстве. В качестве материала для исследования использованы 204 особи американских норок, из которых 99 диких особей, населявших территорию Тверской и Псковской областей, 46 одомашненных породы сапфир, 32 породы серебристо-голубая, 27 породы стандартная коричневая. Установлены средние значения индекса полового диморфизма всех групп исследуемых животных, выявлена достоверно направленная асимметрия. На основании полученных данных выдвинуты предположения о природе наблюдаемых явлений. Настоящая работа призвана расширить имеющиеся малочисленные данные по морфологической изменчивости посткраниального скелета дикой и доместцированной американской норки.

The index of sexual dimorphism and symmetry of the postcranial skeleton was analyzed for 20 morphometric traits in wild and domesticated American minks (Neovison vison). 204 American minks were used as material for the study, of which 99 wild individuals inhabited the Tver and Pskov regions, 46 were domesticated sapphire breeds, 32 belonged to silver-blue breeds, and 27 wre standard brown breeds. The average values of the sexual dimorphism index of all groups of studied animals were established, and reliably directed asymmetry was revealed. On the basis of the received data assumptions about the nature of the observed phenomena are put forward. The present work is intended to expand the limited data available on the morphological variability of the postcranial skeleton of wild and domesticated American mink.
Analysis of the fractal parameters of the leaves of Aegopodium podagraria in the recreational zones of the city of Tver by the methods of multifractal thermodynamics
Authors: Мейсурова Александра Федоровна , Цветков Виктор Павлович , Цветков Илья Викторович , Нотов Александр Александрович
Published: August 2022

Фрактальный анализ листьев сныти обыкновенной (Aegopodium podagraria L.) в рекреационных зонах г. Твери с разным уровнем антропогенной трансформации показал высокую степень сходства структуры поверхности листьев с фракталами. Степень уклонения δ в интервале 0,011-0,024. Проанализированы параметры мультифрактальной термодинамики A и γ. Значения γ индексов фрактальных уравнений состояния листьев коррелируют с уровнем антропогенной трансформации биотопов и загрязнением почв тяжелыми металлами и металлоидами. Индекс γ возрастает при увеличении степени преобразования биотопа и степени загрязнения почв. Минимальные значения γ выявлены в зонах с крупными фрагментами лесных фитоценозов, а минимальные - в посадках деревьев в центре города. Полученные результаты представляют интерес для выяснения перспектив использования данного подхода в биомониторинге.

Fractal analysis of Aegopodium podagraria L. leaves in the recreational zones of Tver with different levels of anthropogenic transformation showed a high degree of similarity of the leaf surface structure with fractals. The degree of deviation δ was in the range 0.011-0.024. The parameters of multifractal thermodynamics A and γ are analyzed. The values of γ indices of fractal equations of leaf condition correlate with the level of anthropogenic transformation of biotopes and soil pollution by heavy metals and metalloids. The γ index increases with increasing degree of biotope transformation and degree of soil contamination. The minimum values of γ were found in areas with large fragments of forest phytocenoses, and the minimum values were recorded for tree plantings in the downtown. The obtained results are of interest for biomonitoring.
On the bioindication value of Acer platanoides L. and Betula pendula ROTH. in the conditions of Tver: the method of fluctuating asymmetry
Authors: Дрожжин Дмитрий Александрович , Виноградова Елена Андреевна , Болдырева Юлия Сергеевна , Курова Мария Сергеевна , Захарова Кристина Владимировна , Наставникова Мария Евгеньевна , Зинякина Анастасия Алексеевна , Пудовкина Татьяна Андреевна , Емельянова Алла Александровна , Николаева Наталья Евгеньевна
Published: August 2022

В 9 точках г. Твери и одной контрольной (г. Весьегонск Тверской области) произведена оценка состояния среды с применением метода флуктуирующей асимметрии. Сравниваются данные, полученные для двух видов-индикаторов: клена остролистного (Acer platanoídes L.) и березы повислой (Betula pendula Roth.). Установлено, что в условиях интенсивной антропогенной нагрузки в г. Твери более удачным биоиндикатор - клен остролистный, сохраняющий способность соответствовать балльной шкале отклонений от нормы. Уровень феногенетических отклонений от нормы у березы повислой во всех обследованных точках г. Твери соответствует критическому. Наблюдается зависимость величины интегрального показателя стабильности развития от степени загрязнения среды в районе произрастания деревьев.

At 9 points in Tver and one control point (Vesyegonsk, Tver region), the state of the environment was assessed using the method of fluctuating asymmetry. The data obtained for two indicator species are compared: holly maple (Acer platanoides L.) and hanging birch (Betula pendula Roth.). It was found that in conditions of intense anthropogenic load in Tver, the more successful bioindicator is the holly maple, which retains the ability to correspond to the point scale of deviations from the norm. The level of phenogenetic deviations from the norm in the hanging birch in all surveyed points of Tver corresponds to the critical one. There is a dependence of the value of the integral indicator of development stability on the degree of environmental pollution in the area of tree growth.
Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function
Authors: Kowalczyk Dominika , Nakasone Mark A , Smith Brian O , Huang Danny T
Published: August 2022

ARF tumor suppressor protein is a key regulator of the MDM2-p53 signaling axis. ARF interferes with MDM2-mediated ubiquitination and degradation of p53 by sequestering MDM2 in the nucleolus and preventing MDM2-p53 interaction and nuclear export of p53. Moreover, ARF also directly inhibits MDM2 ubiquitin ligase (E3) activity, but the mechanism remains elusive. Here, we apply nuclear magnetic resonance and biochemical analyses to uncover the mechanism of ARF-mediated inhibition of MDM2 E3 activity. We show that MDM2 acidic and zinc finger domains (AD-ZnF) form a weak intramolecular interaction with the RING domain, where the binding site overlaps with the E2∼ubiquitin binding surface and thereby partially reduces MDM2 E3 activity. Binding of human N-terminal 32 residues of p14ARF to the acidic domain of MDM2 strengthens the AD-ZnF-RING domain interaction. Furthermore, the N-terminal RxFxV motifs of p14ARF participate directly in the MDM2 RING domain interaction. This bivalent binding mode of p14ARF to MDM2 acidic and RING domains restricts E2∼ubiquitin recruitment and massively hinders MDM2 E3 activity. These findings elucidate the mechanism by which ARF inhibits MDM2 E3 activity.
RANCANGAN SISTEM KONTROL MANAJEMEN PERSEDIAAN TOKO BINTANG TERANG
Authors: Halim Cathalina
Published: August 2022

Penelitian ini bertujuan untuk merancang sistem kontrol manajemen persediaan Toko Bintang Terang. Penelitian ini menggunakan pendekatan kualitatif yang berfokus pada masalah persediaan yang dihadapi Toko Bintang Terang. Analisis data menggunakan MIT 90’s Framework dan Data Flow Diagram. Sumber data berasal dari hasil wawancara dengan pemilik dan manajer toko serta hasil observasi. Hasil penelitian menunjukkan terdapat 4 kelompok kegiatan yang berhubungan dengan sistem pengontrolan persediaan yaitu perencanaan toko, pembelian, pergudangan, dan logistik. Sistem usulan untuk perencanaan toko berupa pengkategorian persediaan berdasarkan 3 faktor yaitu pergerakan barang, selera konsumen dan event. Sistem pembelian dikategorikan ke dalam 2 proses yaitu sistem pemesanan melalui telepon dan melalui salesman yang datang ke toko. Sistem gudang perlu menerapkan stock opname yang belum dilakukan selama ini serta sistem logistik yang dapat membantu perusahaan menghemat biaya dan meningkatkan pelayanan ke konsumen serta pelanggannya. Adapun sistem ini dapat berjalan optimal apabila owner dan manajer toko melakukan pengawasan dan pengecekan proses manajemen persediaan secara rutin seperti melakukan pengkategorian barang per bulan, stock opname sebulan sekali, dan mengecek pengeluaran logistik apakah sesuai dengan anggaran yang telah direncanakan atau tidak.
PENGARUH LITERASI KEUANGAN DAN RISK ATTITUDE TERHADAP KEPEMILIKAN ASURANSI JIWA
Authors: Wahono Cindy , Leng Pwee
Published: August 2022

Pemahaman masyarakat terhadap kepemilikan asuransi terbukti rendah yang terlihat dari rendahnya indeks literasi asuransi di Indonesia. Hal serupa juga ditunjukkan dengan sedikitnya masyarakat yang telah memiliki asuransi di usia muda. Kepemilikan asuransi juga dipengaruhi oleh bagaimana sikap masyarakat dalam mengurangi maupun menanggulangi risiko. Penelitian ini ditujukan untuk melihat pengaruh literasi keuangan dan risk attitude terhadap kepemilikan asuransi jiwa. Penelitian ini merupakan jenis penelitian asosiatif dengan mengambil 124 responden yang memiliki asuransi jiwa. Pengumpulan data menggunakan kuesioner melalui google form menggunakan penilaian skala likert. Kemudian data dianalisis dengan regresi logistik IBM SPSS Statistik 18. Hasil penelitian menunjukkan bahwa literasi keuangan berpengaruh signifikan terhadap kepemilikan asuransi jiwa sedangkan risk attitude tidak berpengaruh signifikan terhadap kepemilikan asuransi jiwa. Risk Attitude tidak berpengaruh terhadap kepemilikan asuransi dikarenakan masyarakat lebih mengutamakan nilai premi yang rendah. Di sisi lain, kepemilikan asuransi masih dapat ditingkatkan dengan menambah wawasan masyarakat akan kegunaan dan manfaat asuransi terutama untuk perencanaan dan pengelolaan keuangan pribadi.
ANALISIS RASIO PERTUMBUHAN PREMI DAN RISK BASED CAPITAL TERHADAP RETURN ON ASSETS YANG DIMEDIASI OLEH RASIO BEBAN KLAIM PADA PERUSAHAAN ASURANSI
Authors: William William , Colline Fredella
Published: August 2022

Pada masa pandemi banyak perusahaan mengalami dampak dari pandemi tidak terkecuali perusahaan asuransi. Penelitian ini dilakukan dengan pendekatan kuantitatif dengan metode analisis regresi linear berganda dengan menggunakan software SPSS 23. Sampel pada penelitian ini ditentukan dengan metode purposive sampling dengan kriteria perusahaan asuransi umum yang terdaftar di Bursa Efek Indonesia yang melaporkan laporan keuangan interim pada Q1 2019 sampai Q3 2021, sehingga didapatkan sampel sebanyak 10 perusahaan. Data yang didapatkan dalam penelitian ini berupa data sekunder dengan mengunduh laporan keuangan interim perusahaan asuransi pada website Bursa Efek Indonesia. Pengujian hipotesis pada penelitian ini dilakukan dengan menggunakan uji t, dan uji sobel. Hasil penelitian ini menunjukkan bahwa rasio pertumbuhan premi dan risk based capital memiliki pengaruh terhadap return on assets. Kemudian rasio pertumbuhan premi dan risk based capital memiliki pengaruh terhadap rasio beban klaim, sementara rasio beban klaim tidak memiliki pengaruh terhadap return on assets dan rasio beban klaim dapat memediasi pengaruh rasio pertumbuhan premi dan risk based capital terhadap return on assets.
STEM Teaching Materials Integrated With Arduino Science Journal For Biology Prospective Teachers
Authors: Nawawi Nawawi , Dafrita Ivan Eldes
Published: August 2022

One effort made by the Biology Education Study Program to provide 21st-century skills to prospective biology teacher-students is to teach STEM through STEM courses. This research covers the issue of developing innovative learning-based teaching materials and developing 21st-century competencies. The research design used in product development was referred to the Thiagarajan 4D development model, such as the define, design, develop, and disseminate stage. The research objective is to understand STEM learning materials based on Arduino Science Journal in improving prospective 21st-century biology teachers. In particular, to determine: (1) The level of validity of Arduino Science Journal-based STEM teaching materials in increasing 21st-century biology teacher candidates. (2) The levels of the practicality of STEM teaching materials based on the Arduino Science Journal to improve prospective 21st-century biology teachers. (3) The Effectiveness of Arduino Science Journal-Based STEM Teaching Materials in Improving the Learning Outcomes of Prospective 21st Century Biology Teachers. The data of research is the percentage value of the validity and practicality. The results of this study indicated that the Arduino Science Journal integrated STEM teaching materials developed, had satisfied the criteria of validity and practicality, and were used effectively in STEM learning.
The Effect of Dobutamine Administration on Oxygen Saturation in Infant's Persistent Pulmonary Hypertension of The Newborn (PPHN)
Authors: Itaqullah Yusfa Iswinda , Airlangga Muhammad Perdana , Triastuti Nenny , Djalilah Gina Noor , Anas Muhammad
Published: August 2022

Background: PPHN of infants are severe cases because the rate of disability and death in infants is relatively high, reaching around 10-20% of cases. Therefore, prompt, accurate, and rational management is needed to reduce cases number of records and deaths. The incidence of PPHN is 2-6 out of 1000 live births; in Surabaya, the incidence was 42 babies per 1000 live births from April to September 2017. Dobutamine is an effective therapy that can support good morbidity and mortality. Therefore, therapeutic options in infants with PPHN in the form of dobutamine are often used.Objective: To determine the effect of dobutamine administration on oxygen saturation in infants with persistent pulmonary hypertension of the newborn (PPHN)Method: A cross-sectional design with a consecutive sampling of 50 infants with PPHN who received dobutamine therapy at the Hospital of Siti Khodijah Muhammadiyah Sepanjang. Data collection using medical records. Results: The average increase in oxygen saturation before and after being given dobutamine was 36.0%. No difference in the increase in oxygen saturation based on the duration of dobutamine administration. The dobutamine dose's effect on the oxygen saturation increase in infants with PPHN.Conclusion: The results of this study indicate a significant effect of dobutamine administration on increasing oxygen saturation in PPHN infants.
Aplikasi Sistem Presensi Dosen Dan Mahasiswa Fakultas Ilmu Pendidikan UNM
Authors: Mus Sumarlin , Mustafa Mustafa
Published: August 2022

Sistem absensi mahasiswa secara manual masih diterapkan di Fakultas Ilmu Pendidikan Universitas Negeri Makassar. Berdasarkan analisis situasi ditemukan masalah yang dihadapi Fakultas Ilmu Pendidikan Universitas Negeri Makassar dalam penggunaan absensi manual mahasiswa yaitu: (1) Sistem absensi yang sedang berjalan saat ini di Fakultas Ilmu Pendidikan Universitas Negeri Makassar masih berdasarkan absensi manual tanda tangan hal ini menyebabkan banyak kendala terutama pada keakurasian data waktu dan kehadiran. (2) Kendala-kendala umum dalam proses absensi mahasiswa di Fakultas Ilmu Pendidikan Universitas Negeri Makassar dalam hal ini lebih kepada akurasi data yang ada karena dapat dimanipulasi sebab masih menggunakan kertas dan tanda tangan. (3) Sulit untuk mencari arsip laporan data absensi mahasiswa untuk pendataan ulang jika proses manual absensi telah berjalan lama. Dari analisis situasi di atas sehingga peneliti tertarik untuk mengembangkan aplikasi presensi dosen dan mahasiswa di Fakultas Ilmu Pendidikan Universitas Negeri Makassar. Hasil penelitian ini berupa produk aplikasi yang dapat dibuka pada laman http://absen.fip.unm.ac.id/ yang telah diujicobakan pada semester ganjil tahun ajaran 2020/2021
Penerapan Pembelajaran Project Based Learning Dalam Meningkatkan Pola Hidup Bersih Dan Sehat Pada Paud
Authors: Aksa Sulikhah , Bachtiar Muhammad Yusri , Indrawati Indrawati
Published: August 2022

Abstract,The purpose of this study is to describe how the application of project-based learning influences the habituation of a clean and healthy lifestyle in early childhood using research and development method. This research was conducted in TK 'Aisyiyah Bustanul Athfal 2 Sumberpucung Malang Regency with 5 randomly selected subjects in group B. Based on the research, it was found that the application of the project based learning model in children's learning was able to familiarize children with a clean and healthy lifestyle.Abstrak, Tujuan penelitian ini yaitu untuk mengetahui gambaran bagaimana pengaruh penerapan pembelajaran projectbased learning terhadap pembiasaan pola hidup bersih dan sehat pada anak usia dini yang menggunakan metode penelitian research dan development. Penelitian ini dilakukan di TK ‘Aisyiyah Bustanul Athfal 2 Sumberpucung Kabupaten Malang dengan subjek yang dipilih secara acak sebanyak 5 anak kelompok B. Berdasarkan dari penelitian didapatkan bahwa penerapan model projectbased learning pada pembelajaran anak mampu membiasakan anak dalam pola hidup bersih dan sehat.
Meningkatkan Kreatifitas Menggambar Melalui Teknik Fingerprint Pada Anak Usia Dini
Authors: Khotimah Khusnul , Parwoto Parwoto , Suriani Suriani
Published: August 2022

Abstract. This research aims to find out the improvement of drawing creativity through fingerprint techniques; The analysis was carried out by direct practice methods with the approach of Class Action Research; the subjects of the study were the children of group B of Hidayatul Qur'an Kindergarten, which numbered ten learners the division of 5 boys and five girls. The object of this study is the ability to draw with data collection techniques, namely observation and documentation. Research instruments are used as observation guides for data analysis techniques. The results showed that fingerprint techniques could increase drawing creativity in children of group B of Hidayatul Qur'an Panyuran-Palang-Tuban Kindergarten.Abstrak. Penelitian ini bertujuan untuk mengetahui peningkatan kreatifitas menggambar melalui Teknik fingerprint, Penelitian dilakukan dengan metode praktik langsung dengan pendekatan Penelitian Tindakan kelas, subyek penelitian yakni anak kelompok B TK Hidayatul Qur’an yang berjumlah 10 peserta didik dengan pembagian 5 anak laki-laki dan 5 anak perempuan. Obyek pada penelitian ini yakni kemampuan menggambar dengan teknik pengumpulan data yaitu observasi dan dokumentasi. Instrumen penelitian yang digunakan berupa panduan observasi teknik analisis data. Hasil penelitian menunjukkan bahwa penerapan teknik fingerprint dapat meningkatkan kreatifitas menggambar pada anak kelompok B TK Hidayatul Qur’an Panyuran-Palang-Tuban.
Upaya Meningkatkan Kemampuan Bercerita Melalui Media Gambar Seri Pada Anak Kelompok B
Authors: Rismawati Rismawati , Bastiana Bastiana , Ramlah Ramlah
Published: August 2022

This study aims to determine the improvement of the speech skills of kindergarten students in terms of telling stories or responding to teacher questions. In this case, the child's ability is lacking due to the teacher's lack of stimulus, the image media used by the teacher is less attractive and not varied, or the child's environment is less supportive. The research was carried out at the Sulawesi Kindergarten which is located at jalan tupai no.98 kelurahan labuang baji, mamajang district Makassar. It was carried out in group B with 14 children divided into eight boys and six girls. The problem-solving in group B is carried out using the media of a series of images made by the teacher. The objective is to (a) describe the use of illustrated media and (b) describe the increase in children's speaking activities, especially storytelling through image media. (c) present the results of improving children's speaking skills, especially in terms of storytelling, after learning with series image media, Data collection using learning and observation results. The collected data were analyzed by descriptive analysis. And obtained an average score, in cycle I, the ability to speak and respond to children was 28.87%, cycle II became 57.14%, and in the third cycle, it became 64.26%. From the results of these percentages, series image media can improve children's participation skills with the support of varied and exciting methods and involve children in each activity. Penelitian ini bertujuan untuk mengetahui peningkatan kemampuan berbicara anak didik TK dalam hal bercerita ataupun merespon pertanyaan guru. Dalam hal ini, kemampuan anak kurang dikarenakan guru yang kurang memberikan stimulus atau media gambar yang digunakan guru kurang menarik dan tidak bervariasi ataupun lingkungan anak yang kurang mendukung. Adapun penelitian dilaksanakan di Taman kanak-kanak Sulawesi yang beralamat di jalan tupai no.98 kelurahan labuang baji, kecamatan mamajang Makassar. Dilakukan di kelompok B dengan jumlah anak sebanyak 14 anak yang terbagi atas 8 anak laki-laki dan 6 anak perempuan. Adapun penyelesaian masalah di di kelompok B ini dilakukan dengan menggunakan media gambar seri yang dibuat guru. Tujuannya yaitu (a) mendeskripsikan penggunaan media bergambar (b) menggambarkan peningkatan aktifitas berbicara anak khususnya bercerita melalui media gambar. (c) memaparkan hasil peningkatan kemampuan berbicara anak khususnya dalam hal bercerita setelah menggunakan pembelajaran dengan media gambar seri. Pengambilan data dengan menggunakan hasil belajar dan observasi. Data yang dikumpulkan dianalisis dengan analisis deskriptif. Dan diperoleh skor rata-rata, pada siklus I, kemampuan berbicara dan merespon anak 28,87%, siklus II menjadi sebesar 57,14% dan pada siklus ke III menjadi sebesar 64,26%. Dari hasil persentase tersebut, media gambar seri dapat meningkatkan kemampuan bercerrta anak dengan dukungan metode yang bervariasi dan menarik serta melibatkan anak dalam setiap kegiatan.
Meningkatkan Kemampuan Membaca Melalui Media Kartu Kata Pada Anak Usia Dini
Authors: Nur aini Nur aini , Bachtiar Muhammad Yusri , Indrawati Indrawati
Published: August 2022

This study generally aims to improve children's language skills in reading through word cards in group B at Tunas Harapan Kindergarten, Wringin District, Bondowosos Regency. The method applied in this research is the Classroom Action Research approach. (CAR) with the subject of group B totaling 20 children. Data analysis technique by holding two limited face-to-face meetings. This Classroom Action Research shows an increase in early childhood reading skills through the make a match method with word card media. This is evidenced by the results of the achievement of student development has increased; at the first meeting the achievement of student development was 52% and at the second meeting was 87%. Thus, it can be concluded that the use of word card media can improve children's ability to read in Tunas Harapan Kindergarten, Wringin District, Bondowoso Regency. Penelitian ini bertujuan untuk meningkatkan bahasa anak tentang kemampuan membaca melalui media kartu kata pada kelompok B di TK Tunas Harapan Kecamatan Wringin Kabupaten Bondowoso. Metode yang diterapkan dalam penelitian ini yaitu pendekatan Penelitian Tindakan Kelas (PTK) dengan subjek anak kelompok B yang berjumlah 20 anak. Teknik analisis data dengan mengadakan 2 pertemuan tatap muka terbatas. Penelitian Tindakan Kelas ini menunjukkan peningkatan kemampuan membaca awal bagi anak usia dini melalui penggunaan metode make a match dengan media kartu kata. Hal ini dibuktikan dengan hasil pencapaian perkembangan siswa mengalami peningkatan, pada pertemuan ke I pencapaian perkembangan siswa sebesar 52% dan pada pertemuan ke II adalah 87%. Dengan demikian, dapat disimpulkan bahwa penggunaan media kartu kata dapat meningkatkan kemampuan anak dalam membaca di TK Tunas Harapan Kecamatan Wringin Kabupaten Bondowoso.
Penerapan Kompetensi Kewirausahaan Kepala Sekolah
Authors: Jannah Miftahul , Mus Sumarlin , Irmawati Irmawati
Published: August 2022

This research examines how to apply the entrepreneurial competence of principals at SMKN 6 Pangkep, which is focused on school development innovation. The purpose of this study was to determine how principals' entrepreneurial competence in creating innovations that are useful for school development at SMKN 6 Pangkep. This research approach is nonionic qualitative with a descriptive research type—data collection techniques in the form of interviews, observations, and documentation. The interview data analysis technique uses data reduction, data exposure, drawing conclusions and checking the validity of the data using the triangulation technique. The result showed the application of principals' entrepreneurial competence in school development innovation. School development innovation can be seen in the principal’s ability to act creatively and innovatively, empower school competencies, and foster an entrepreneurial spirit. The form of creative and innovative actions taken by the principal is to create a comparative advantage, the state of empowering school potential carried out by the principal is through the utilization of existing natural resources related to culture in school and the form of fostering an entrepreneurial spirit by the principal is applied through entrepreneurial learning, industrial work practice activities, and school business unit management. Penelitian ini mengkaji tentang bagaimana penerapan kompetensi kewirausahaan kepala sekolah di SMKN 6 Pangkep yang difokuskan pada inovasi pengembangan sekolah. Tujuan penelitian ini adalah untuk mengetahui bagaimana gambaran kompetensi kewirausahaan kepala sekolah dalam menciptakan inovasi yang berguna bagi pengembangan sekolah. Pendekatan penelitian ini adalah kualitatif dengan jenis penelitian deskriptif. Teknik pengumpulan data berupa wawancara, observasi, dan dokumentasi. Teknik analisis data menggunakan reduksi data, paparan data dan penarikan kesimpulan. Pengecekan Keabsahan data menggunakan teknik trianggulasi. Hasil penelitian menunjukkan bahwa penerapan kompetensi kewirausahaan kepala sekolah di SMKN 6 Pangkep dalam hal inovasi pengembangan sekolah. Inovasi pengembangan sekolah dapat dilihat dari kemampuan kepala sekolah dalam bertindak kreatif dan inovatif, memberdayakan kompetensi sekolah, dan menumbuhkan jiwa kewirausahaan.  Bentuk tindakan kreatif dan inovatif yang dilakukan oleh kepala sekolah yaitu menciptakan keunggulan kompartif, bentuk pemberdayaan potensi sekolah yang dilakukan oleh kepala sekolah yaitu melalui pemanfaatan sumber daya alam yang ada terkait budaya di sekolah, dan bentuk menumbuhkan jiwa kewirausahaan oleh kepala sekolah diterapkan melalui pembelajaran kewirausahaan, kegiatan praktik kerja industri (prakerin), dan pengelolaan unit bisnis sekolah.
Confidentiality of the notary deed in the freedom of the academic pulpit
Authors: Margiyanti Reni , Negara Tunggul Anshari Setia , Sjafi’i R. Imam Rahmat
Published: August 2022

Many academic community members abuse the academic pulpit's freedom for inappropriate purposes. The purpose of this paper is to analyze the conflict or conflict of norms in the Article related to the obligation of a Notary to keep everything regarding the Deed he made and the explanation of the Article associated with the freedom of the academic pulpit (Article 8 Paragraph (1), Law of the Republic of Indonesia Number 12 the Year 2012), in the Republic of Indonesia. On the one hand, a notary must keep everything about the deed he made secret; on the other hand, a notary who is a teaching staff or lecturer must carry out his duties as an academic civitas. This writing uses a normative juridical method with a statute and conceptual approach. The results obtained are that the position of a notary is higher than the position of a notary as a lecturer; therefore, the notary's limitations regarding the academic pulpit are to the position of a notary as a public official, whereas a public official a notary is obliged to keep everything related to the deed he made, which means that he has been ordered to a notary. Not to give, show or notify the act’s contents except those with a direct interest. Therefore, regulators should study further if there is a conflict of norms in the Articles related to the Notary's obligation to keep everything confidential regarding the Deed he made.How to cite item: Margiyanti, R., Negara, T, A, S.,. Sjafi’i, R, I, R., (2022), Confidentiality of the notary deed in the freedom of the academic pulpit. Jurnal Cakrawala Hukum, 13(2). 184-193. doi:10.26905/idjch.v13i2.5735.
РОЗРОБКА СИСТЕМИ ВИЯВЛЕННЯ КІБЕРЗАГРОЗ НА ОСНОВІ АНАЛІЗУ ДАНИХ З ВЕБ-РЕСУРСІВ НА МОВІ ПРОГРАМУВАННЯ PYTHON
Authors: Prokopov V. , Meleshko Ye. , Yakymenko M. , Reznichenko V. , Shymko S.
Published: August 2022

Метою даної роботи є створення системи виявлення кіберзагроз на основі аналізу даних мережевого трафіку веб-ресурсів засобами мови програмування Python та з використанням методів машинного навчання. Об’єктом дослідження є процес аналізу даних з веб-ресурсів у системах кібербезпеки. Предметом дослідження є методи та алгоритми машинного навчання для аналізу даних з веб-ресурсів. Для навчання розробленої моделі виявлення кібератак було обрано відкритий набір даних CSE-CIC-IDS2017, що містить найсучасніші поширені інформаційні атаки, що відповідають вигляду справжніх даних з реального світу, основні реалізовані атаки включають брутфорс FTP, брутфорс SSH, DoS, Heartbleed, веб-атаку, інфільтрацію, ботнет та DDoS. Розроблене програмне забезпечення виявлення кібератак на веб-сайти складається з декількох модулів, а саме: модуля попередньої обробки даних датасету, модуля дослідження ознакового простору мережевого трафіку та модуля використання алгоритмів машинного навчання для пошуку кібератак. Для вирішення завдання з відбору ознак у рамках реалізації даного програмного забезпечення було вирішено обрати стратегію відбір на основі моделі за допомогою одного з ансамблевих методів машинного навчання випадковий ліс. Відбір ознак на основі моделі використовує алгоритм машинного навчання з учителем, щоб обчислити важливість кожної ознаки, і залишає лише найважливіші з них. Для тренування моделі були вибрані наступні алгоритми машинного навчання: наївний баєсів класифікатор, k-найближчих сусідів, дерева рішень, метод опорних векторів (SVM) з використанням гауссівського ядра, адаптивний бустинг, дерева рішень з прискоренням (бустинг градієнта). Разом з тренуванням одразу виконувалася перехресна перевірка (з контролем) по семи блоках, для отримання більш точної оцінки узагальнюючої здатності моделі. Результат роботи – програмна реалізація методів машинного навчання для виявлення кібератак на веб-сайти за допомогою розпізнавання їх ознак у мережевому трафіку, а також проведення порівняння їх ефективності.
A YOLO Detector Providing Fast and Accurate Pupil Center Estimation using Regions Surrounding a Pupil
Authors: Kurdthongmee Wattanapong , Kurdthongmee Piyadhida , Suwannarat Korrakot , Kiplagat Jeremy K.
Published: August 2022

Eye-tracking technology has many useful applications, including Virtual Reality (VR) devices, Augmented Reality (AR) devices, and assistive technology. The main objective of eye-tracking technology is to detect eye position and track eye movements. It is possible to determine the eye position when the pupil center is detected. In this paper, a deep learning-based approach to the detection of pupil centers from webcam images is presented. As opposed to all previous approaches to object detection based on training the detector with objects to be detected, our object detector was trained with both the region surrounding a pupil and the region between an eye and the region surrounding a pupil. The latter set of regions has been found to increase the overall detection accuracy. A novel post-processing algorithm is also presented to estimate the pupil center from all the detected regions. To achieve real-time performance, we have adopted the tiny architecture of YOLOv3, which has 23 layers and can be executed without requiring a GPU accelerator. To train the detectors, different variations of regions covering a pupil and an eye were used, as well as expanding regions surrounding a pupil and an eye. The PUPPIE dataset was used as the primary input for training the detector. The setting with the best detection accuracy was applied to all publicly available datasets: I2Head, MPIIGaze, and U2Eyes. In terms of accuracy, the results indicate that pupil center estimation is comparable to the state-of-the-art approach. It achieves pupil center estimation errors below the size of a constricted pupil in more than 98.24% of images. Furthermore, the detection time is 2.8 times faster than the state-of-the-art approach. Doi: 10.28991/ESJ-2022-06-05-05 Full Text: PDF
El concepto de nación entre la desintegración del virreinato del Nuevo Reino de Granada y la emergencia de la república de Colombia
Authors: Rodríguez Jaime Alberto
Published: August 2022

El artículo ofrece una reconstrucción de la red semántica del concepto de nación. Con este propósito toma en cuenta tres factores importantes: primero, los acontecimientos y sus efectos en las decisiones de los actores; segundo, los lenguajes y conceptos políticos (como índices de los procesos y como factores de transformación); y, por último, los componentes culturales, especialmente las identidades territoriales. Esta propuesta evidencia la complejidad a la que se enfrenta el investigador a la hora de reconstruir una red semántica determinada, por cuanto se tienen que combinar elementos estructurales y coyunturales.
Orígenes y problemas de la escuela rural en el Ecuador: 1870-1930
Authors: Luna Tamayo Milton
Published: August 2022

¿Cómo se desarrolló la política de apertura y funcionamiento de la escuela rural en Ecuador en el periodo 1870-1930 y cuáles fueron los problemas que impidieron el desarrollo de la escuela rural en este lapso? La investigación constató que la limitada preocupación del estado central por el fomento de la educación rural, en particular la educación indígena, no sólo se debió a la carencia de recursos o a la ineficiencia de la administración pública, sino a algo más profundo: a la decisión de las élites nacionales gobernantes de dirigir las prioridades de las políticas estatales a apuntalar la modernidad y construir la nación, excluyendo al mundo indígena y rural, fortaleciendo las ciudades y las clases medias, dos fenómenos que no solo se presentaron en el Ecuador sino en toda América Latina.
Factores que inciden en el rendimiento laboral en los profesores del nivel medio superior y superior durante las clases en línea
Authors: Solís Peña Carolina , Lara Jiménez Valentín , González Palomo Iván Guillermo , Cuellar Celestino Jhonathan
Published: August 2022

En la actualidad, por la reciente contingencia COVID-19, la actividad laboral ha evolucionado y se ha tenido que adaptar a nuevas modalidades de trabajo. Estas nuevas modalidades han provocado problemas de salud mental. Esta investigación determina si las características propias del trabajador, el burn out y las características del área de trabajo son los factores que inciden en el rendimiento laboral en profesores del nivel superior y medio superior durante las clases en línea. Se aplicó el instrumento de medición a una muestra tomando en cuenta características cuantitativas y cualitativas del sujeto de estudio, destacando género, edad, nivel de estudios y en área donde se imparten las clases. Esta investigación contribuye al conocimiento definiendo estrategias para el rendimiento de los trabajadores docentes, concluyendo que es fundamental el recurso humano que realiza la labor docente, independiente a la modalidad de la clase. El sujeto de estudio, no presenta indicios de burn out o de malestar físico por la modalidad remota, mientras que las características propias del trabajador en este caso d
Aplikasi Berbasis Android dalam Penanganan Obesitas Anak Usia Sekolah: Literature Review
Authors: Syifa Khoirunnisa As , Rohayati Rohayati , Verdyan Nesya Pradini , Kartika Parikesit Nuril , Suci Rara Angia , Rohmawati Rohmawati , Latifani Veny
Published: August 2022

Obesitas merupakan masalah kesehatan masyarakat di dunia yang terus meningkat seiring waktu. Obesitas pada usia anak akan berlanjut hingga usia dewasa jika tidak segera ditangani. Program pencegahan obesitas pada anak dapat dilakukan dengan menginterasikan teknologi.  Literatur review ini bertujuan untuk mengetahui aplikasi berbasis android yang digunakan dalam pencegahan obesitas pada anak. Tulisan ini menggunakan pendekatan literatur review. Penelusuran elektronik meliputi database Pubmed, Clinical Key Nursing, Science Direct, EbscoHost dan Proquest menggunakan kata kunci yang sudah ditentukan. Kriteria inklusi artikel adalah dipublikasikan antara tahun 2015-2020, berbahasa Inggris, populasi intervensi pada anak usia sekolah dasar. Sembilan artikel memenuhi kriteria inklusi. Analisis yang dilakukan dengan menggunakan tema. Hasil menunjukkan bahwa aplikasi yang digunakan dalam pencegahan obesitas anak terbagi menjadi aplikasi berbasis android/ smartphone, aplikasi berbasis telehealth dan mHealth, aplikasi berbasis social media serta digital device  yang dikenakan ditubuh. Studi selanjutnya diharapkan dapat mengembangkan prototype aplikasi pencegahan obesitas berbasis teknologi dengan memperhatikan perkembangan anak dan sosial budaya.
Copyright and Contracts: Issues and Strategies
Authors: Klosek Katherine
Published: August 2022

In 2020, ARL’s Advocacy and Public Policy Committee launched a digital rights initiative focused on understanding and safeguarding the full stack of research libraries’ rights: to acquire and lend digital content to fulfill libraries’ functions in research, teaching, and learning; to provide accessible works to people with print disabilities; and to fulfill libraries’ collective preservation function for enduring access to scholarly and cultural works. Our objective is to make sure that these rights are well understood by research libraries, by Congress, by the US Copyright Office, and by the courts. This report discusses licenses and contracts for digital content in the context of the US Copyright Act. The report presents advocacy and public policy strategies, such as rights-saving clauses, open access, state strategies, and federal exemptions. The report concludes with next steps, including a test case and ARL strategies.