bluuebunny/crossref_metadata_2025 huggingface dataset:
To question of the definition "budget revenues"
Authors: К. О. Токарєва
Published: December 2022

The article discusses various approaches to the definition of budget revenues, their characteristics and classification. Considerable attention is given to studying the relation "of budget revenues" with adjacent categories. Analyzed budgetary norms of Ukraine and the Russian Federation.
Sanatta Beden Temsilinin Dönüşümü:Kusurlu Beden
Authors: Özyonar  Çırak Burcu
Published: December 2022

Sanatın merkezinde yer alan beden, geçmişten günümüze sosyolojik, politik, inanç ve bilim gibi etkenlerle dönüşüme uğramıştır. Sanatta kusursuzluğu ile konumlanan beden temsili, zamanla yerini karşıtı olan kusurlu bedene bırakmıştır. Sanattaki bu yeni temsil kusurlu sayılan bedenin öteki olmaktan kurtarılması bakımından önem taşımaktadır. Bu nedenle sanatta yeni entegre olan bu anlayışın incelenmesinin faydalı olacağı düşünülmektedir. Bu çalışmada kusurlu beden temsilinin yakından ve günümüz örnekleri ile incelenmesi amaçlanmıştır.
Nitel yaklaşımının benimsendiği betimsel olan bu çalışmada konuyla ilgili güncel basılı ve elektronik kaynaklardan faydalanılmıştır. Eserlerinde ölü, hasta ve deforme beden temsillerine yer veren, farklı disiplin, malzeme ve teknik kullanan Kiki Smith, Marc Quinn, Janine Antoni, Emma Hopkins, Virginia Bersabe ve Magda Hueckel’ in eserleri incelenmiştir. Çalışmada incelenen sanatçıların, hasta, eksik ve fani beden formlarını sanatlarına dahil ettikleri, bedenin görünmeyen, örtbas edilen zayıf yanlarıyla barıştıkları ve kusurlu olanı sanatta görünür kılmayı başardıkları sonucuna ulaşılmıştır.
Development of a new generation flotation cell and monitoring of air bubbles
Authors: Aytac Ayca , Tuna Muhammed Cihat
Published: December 2022

The flotation process allows particles and oil to separate from wastewater with high efficiency. Therefore, it is widely used in engineering and is a multidisciplinary field of study. In this study, a new generation flotation method is developed as an alternative to conventional flotation methods. Some experiments are conducted to determine the performance of this new system. It is known that the air-demand rate in the flotation process directly improves flotation performance. For this purpose, maximum aeration efficiency and bubble properties in the flotation cell supported by the newly developed head gated conduit are examined. A pilot-scale flotation system is installed for the experimental study. With the help of high resolution and high-speed cameras, parameters such as air bubble density, air bubble size, dead zone volume and penetration depth are determined. In addition, the images recorded during the flotation process are examined with professional image processing techniques. Experimental results showed that the Froude number, jet plunge angle and cell water levels have a significant impact on air-demand in the new system.
Diepoxy-treated bovine jugular vein conduit for pulmonary artery replacement
Authors: Nichay N.R. , Zhuravleva I.Yu. , Kulyabin Yu.Yu. , Zykov I.S. , Boyarkin E.V. , Malakhova O.Yu. , Kuznetsova E.V. , Timchenko T.P. , Rusakova Ya.L. , Murashov I.S. , Dokuchaeva A.A. , Bogachev-Prokophiev A.V.
Published: December 2022

Objective: To evaluate the performance and short-term capacity of the diepoxy-treated bovine jugular vein conduit in large animals during 6-month follow-up.Methods: Thirteen diepoxy-treated bovine jugular vein conduits were implanted into the pulmonary artery of young mini-pigs. During the follow-up, graft function was tested using transesophageal echocardiography. The animals were withdrawn at 6 months, and the explanted conduits were assessed histologically.Results: All the conduits were successfully implanted without any surgical complications. All the animals survived throughout the follow-up. By the end of the follow-up period, the pressure gradient increased on five animals’ conduits including one case of mismatch between the conduit and the native pulmonary artery, two cases of distal stenosis, and two case of endocarditis. No significant increase in valve regurgitation or conduit thrombosis was observed during the follow-up. In conduits without dysfunction, the structure of the walls and leaflets was intact. A thin fibrous tissue covered the conduit inner wall with complete surface endothelialization. Neither signs of degeneration or calcification nor inflammatory cells were found in the conduit wall or leaflets. Neointima proliferation without calcium deposits was observed in two distally stenosed conduits. Inflammatory cells consisting of multinucleated macrophages, lymphocytes, and histiocytes were found in the adventitia. There were no inflammatory cells in the media or intima, and the leaflets showed no changes.Conclusion: Diepoxy-treated bovine jugular vein demonstrated acceptable performance, good endothelialization, and low tendency to thrombosis and calcium accumulation in the wall and leaflets.
Received 31 October 2022. Revised 25 November 2022. Accepted 28 November 2022.
Funding: The study was supported by Russian Science Foundation (grant No. 22-25-20102).
Conflict of interest: The authors declare no conflict of interest.
Contribution of the authorsConception and study design: N.R. Nichay, I.Yu. Zhuravleva, A.V. Bogachev-ProkophievData collection and analysis: N.R. Nichay, Yu.Yu. Kulyabin, I.S. Zykov, E.V. Boyarkin, O.Yu. Malakhova, E.V. Kuznetsova, T.P. Timchenko, Ya.L. Rusakova, I.S. Murashov, A.A. DokuchaevaStatistical analysis: N.R. Nichay, I.Yu. ZhuravlevaDrafting the article: N.R. Nichay, I.Yu. Zhuravleva, Yu.Yu. Kulyabin, I.S. Zykov, E.V. Boyarkin, O.Yu. Malakhova, T.P. Timchenko, Ya.L. Rusakova, I.S. Murashov, A.A. DokuchaevaCritical revision of the article: N.R. Nichay, I.Yu. Zhuravleva, Yu.Yu. Kulyabin, A.A. Dokuchaeva, A.V. Bogachev-ProkophievFinal approval of the version to be published: N.R. Nichay, I.Yu. Zhuravleva, Yu.Yu. Kulyabin, I.S. Zykov, E.V. Boyarkin, O.Yu. Malakhova, E.V. Kuznetsova, T.P. Timchenko, Ya.L. Rusakova, I.S. Murashov, A.A. Dokuchaeva, A.V. Bogachev-Prokophiev
Wielokulturowy postliberalizm – kwestia tożsamości
Authors: Sealy Thomas
Published: December 2022

Realia wielokulturowości, czy zróżnicowania kulturowego i religijnego, we współczesnych społeczeństwach Europy Zachodniej są istotnym aspektem postliberalizmu. Fakt ten sprowokował nowy sposób myślenia o pożądanych sposobach zarządzania pluralizmem oraz uwzględnienia, zintegrowania i włączania mniejszości – w szczególności tych, które są postrzegane jako sprzeczne z liberalnymi wartościami świeckimi, ponieważ wyznają bardziej konserwatywne społecznie, nieliberalne (a nawet ograniczające) wartości. W Wielkiej Brytanii wielokulturowość pojawiła się jako teoretyczny i polityczny odzew na ten postliberalny dylemat. Artykuł najpierw pokazuje ten odzew oraz przedstawia, w jaki sposób pokrywa się on z postliberalnymi problemami i zasadami, po czym skupia się na tym, jak religia wpisuje się w ten obraz jako ważny nurt w myśli wielokulturowej i postliberalnej. Artykuł wykazuje, że teoria wielokulturowości wymaga nowego myślenia o religii jako części polityki postliberalnej oraz że teoria ta posiada już potrzebne do tego zasoby.
Pluralizacja religijna a proces integracji europejskiej. Wybrane zagadnienia
Authors: Popiuk-Rysińska Irena
Published: December 2022

Celem artykułu jest identyfikacja i zbadanie wybranych zależności między zróżnicowaniem religijnym a procesem integracji europejskiej. Integrująca się Europa, podzielona początkowo generalnie na katolików i protestantów, uległa pluralizacji pod względem religijnym, przede wszystkim ze względu na napływ ludności prawosławnej i muzułmańskiej, wskutek dołączania nowych państw do pierwotnej integrującej się grupy oraz procesów migracyjnych. Każda z tych religii ma w jakimś  zakresie wypracowaną własną wizję Europy, tożsamości oraz integracji, które oddziałują na postawy społeczne i poglądy polityków. Można zauważyć między innymi zróżnicowanie postaw odnośnie do integracji między katolikami, protestantami, prawosławnymi i muzułmanami, jak również wewnątrz tych wyznań, zależnie od wskazań wiary oraz stopnia zróżnicowania religijności ich wyznawców. Oprócz pośredniego oddziaływania, religia wywiera wpływ poprzez działanie podmiotów „religijnych”, w tym Kościołów, chadeckich partii politycznych, organizacji czy polityków. W artykule, przy odwołaniu do wybranych badań, analizowany jest wpływ pluralizmu religijnego na genezę i rozszerzanie się integracji, jej pogłębianie oraz ideowy wymiar, a także na instytucjonalizację kwestii religijnych w procesie integracji.
Aproximaciones Edith Stein y Erica Fudge en vista a lo animal-humano
Authors: Reyes-Gacitúa Eva
Published: December 2022

Habitualmente se define al hombre evidenciando lo propio de su constitución y comparándolo con seres inferiores: materia, plantas y animales. Desde esta óptica, la cogitatio subraya una frontera esencial entre lo animal y lo humano. No obstante, para esta ocasión, dos filósofas nos permiten ahondar en este planteamiento, apreciando no solo lo diferente, si no lo común entre el animal y lo humano. Ya Stein, se plantea si es posible detectar en los animales algo análogo a las “actitudes humanas”. Por otra parte, Fudge advierte la necesidad de volverse hacia el animal y concebirlo de diferentes maneras. Finalmente revisaremos un topos argumentativo en la comprensión de nuevas argumentaciones y de lenguaje performativo.
Nucleos teo-lógicos del de Imitatione Christi Aportes para la espiritualidad cristiana
Authors: Molteni Agostino
Published: December 2022

La espiritualidad cristiana no puede ser desvinculada de la dogmática. En este sentido, aunque se ha dicho que en el De imitatione Christi está presente esta separación, pensamos que en esta obra, por medio de una lectura que entre en su misma lógica, se pueden reconocer algunos núcleos teológicos-dogmáticos bien sólidos que pueden ser un aporte muy provechoso para que la actual espiritualidad cristiana sea sana en sus contenidos y provechosa en su colaboración en la redención de los hombres obrada por Cristo.
Biodiversidad y responsabilidad: una reflexión desde el pensamiento del Papa Francisco y Hans Jonas
Authors: Sánchez Echeverría Lorena
Published: December 2022

La ética del medio ambiente, como ética aplicada, reflexiona acerca de la responsabilidad que tiene el ser humano con su entorno, reflexión que se ha vuelto necesaria dada la relación que tiene hoy el hombre con el medio ambiente, en el que existe, entre otras cosas, un abuso de los recursos que este provee. Hasta hoy no se habían evidenciado efectos tan graves, tanto para el entorno como para la vida del ser humano. Por esto es necesario que se genere un cambio positivo, real y pragmático que permita al ser humano ser responsable del cuidado de su entorno. Considerando los aspectos teológico-filosóficos señalados por el papa Francisco, en conjunto con el planteamiento de Hans Jonas de una ética para la civilización tecnológica, es que, en esta investigación, se espera canalizar ambas líneas de pensamiento acerca de la responsabilidad hacia ideas prácticas para el actuar humano en pro de la biodiversidad. Además de reconocer el rol de administrador responsable que tiene el ser humano, rol que debe apuntar hacia una ética orientada al futuro, respetando la posición del ser humano responsable del ecosistema y su biodiversidad.
HIF-1α/Malat1/miR-141 Axis Activates Autophagy to Increase Proliferation,
Migration, and Invasion in Triple-negative Breast Cancer
Authors: Zhang Chi , Xu Fangyuan , Hu Yue , Gao Jie , Wang Jianxiong , Xie Yujie , Sun Fuhua , Wang Li , Miyamoto Akira , Xia Ou
Published: December 2022

Background:

The mechanism of metastasis-associated lung adenocarcinoma transcript 1 (Malat1) in triple-negative breast cancer (TNBC) is still unclear.

Objective:

This study aimed to investigate the role of miR-141-3p and Malat1 in autophagy in TNBC under hypoxia.

Method:

The expression levels of Malat1 and miR-141-3p were detected via quantitative real-time polymerase chain reaction (qRT-PCR). The protein expression levels of hypoxia-inducible factor 1α (HIF-1α), HIF-2α, MMP9, p62 and LC3 were determined via western blotting. A Cell Counting Kit-8 assay was used to detect cell viability, while a Transwell assay to detect cell proliferation and invasion. A luciferase assay was used to confirm the relationship between Malat1 and miR-141-3p.

Results:

A significant increase was observed in the expression level of Malat1 and the autophagic activity in TNBC tissues and cells. The expression level of Malat1 was higher in a hypoxic environment, which can significantly promote the proliferation, migration, and invasion of TNBC cells by activating autophagy. HIF-1α, but not HIF-2α, was identified to induce the upregulation of Malat1 in TNBC cells. The dual-luciferase assay results identified a miR-141-binding site in Malat1. Malat1 knockdown and miR-141-3p overexpression were demonstrated to significantly inhibit autophagy, thereby inhibiting cell proliferation, invasion, and migration. Moreover, hypoxia can inhibit the effect of miR-141-3p on TNBC cells.

Conclusion:

miR-141-3p could suppress autophagy and inhibit proliferation, migration, and invasion by targeting Malat1 in TNBC cells under hypoxia. The existence of the HIF-1α/Malat1/miR-141 axis plays a vital role in the development of TNBC and may be a target for the diagnosis and treatment of TNBC.
Effects of Exercise on Vascular Toxicity Associated with Breast Cancer
Treatment: A Narrative Review
Authors: Pera Marina L.D. , Speretta Guilherme F.
Published: December 2022

Breast cancer is the most common cancer among women worldwide, and its incidence is
linearly associated with age. The development of cancer treatments has changed the prognosis of this
disease. Despite effective treatments, cardiovascular complications in middle-aged and older women
have become challenging. Physical exercise is a powerful tool to prevent senescence symptoms and
diseases, besides being an essential component for cardiovascular diseases and cancer prevention and
treatment. The present narrative review considers the vascular dysfunction associated with breast cancer
treatment, specifically chemotherapy and radiotherapy, and the effects of exercise on vascular toxicity.
We also explored the mechanisms involved in these responses. The search strategy involved three databases
(Pubmed, Scielo, and Web of Science) with the following descriptors: breast cancer, vascular
toxicity, physical exercise, chemotherapy, and radiotherapy. The evidence showed that breast cancer
patients, especially those under chemotherapy and over 50 years old, have a potential risk of developing
vascular dysfunction, which may persist in the long term. Decreases in nitric oxide bioavailability and
increases in oxidative stress and pro-inflammatory cytokines might mediate the chemotherapy and radiotherapy-
induced vascular dysfunction. Exercise seems to be a promising strategy for managing this
risk. However, there is a need for well-constructed studies evaluating vascular toxicity in breast cancer,
especially in middle-aged and elderly patients, to establish whether exercise is beneficial.
Cellulose Nanocrystals Prepared by TEMPO-mediated Oxidation of Wild
Musa spp. Pseudostem
Authors: Nath Ranjita , Pachuau Lalduhsanga
Published: December 2022

Valorization of agricultural waste to produce value-added products such as nanocellulose
is important in bringing sustainable development and reduce our dependence on petroleumbased
products which are harmful to our environment. The present work is carried out to investigate
the potential of the pseudostems from the wild Musa spp. as a novel sustainable source of
cellulose nanocrystal (CNCs). TEMPO-mediated oxidation and ultrasonication was followed in
isolation of CNCs. The CNCs were characterized by various physicochemical parameters such as
FTIR, TEM, Zeta potential, degree of oxidation, swelling and water retention value. TGA studies
was performed to evaluate the thermal stability and percent crystallinity was determined by XRD
spectroscopy. The final carboxylated CNC (cCNC) gel contains 5.56% w/w solid CNC exhibiting
degree of oxidation of 34.91%. The CNC also showed high water retention value exhibiting
ionic sensitivity to NaCl. The zeta potential value was determined to be -50.3 mV indicating its
stability and particle size of the cCNC was less than 200 nm. The percent crystallinity was found
to be 66.18% and TGA analysis showed the reduced thermal stability of the cCNCs. Carboxylated
CNC was successfully isolated from the wild banana pseudostem following TEMPOoxidation
method. Ultrasonication of the cCNC resulted in the formation of cCNCs with mostly
spherical in shapes and the results from analysis indicate that the wild banana pseudostem could
be a potential sustainable source of cellulose nanocrystals.
Improving the Chemical and Sensory Properties of Cheddar Cheese Using
Adjunct Cultures
Authors: Khosravi-Darani Kianoush , Massoud Ramona
Published: December 2022

Background:

Dairy consumption and especially cheese consumption has been increasing
in most countries of the world due to its favorable taste. European countries and the
United States are the major producers and consumers of cheese. Due to the nutritional and economic
importance of cheese, various schemes have been considered to increase its consumption
and the most important of which is to improve its sensory properties. Several factors affect the
development of cheese properties including chemical composition, residual coagulation factors,
enzymes in milk, microbial flora of cheese and the storage conditions during the ripening stage,
microorganisms in cheese especially lactic acid bacteria.

Objective:

Various methods have been studied to improve the sensory properties of cheese in the
world and the most successful of which is the addition of adjunct culture. Adjunct cultures are a
variety of selected microorganisms that are added to milk to improve the sensory quality or to
accelerate the ripening of the product. The major adjunct cultures are lactobacilli. Many studies
show that Lactobacillus helveticus LH212 and Lactobacillus helveticus CNRZ32 are among the
most desirable bacteria. Adjunct cultures are used in two ways: attenuated and live cultures.
There are several methods for preparing attenuated cultures, but most researchers focus on physical
methods such as heat shock, freezing shock and spray drying.

Conclusion:

The purpose of this article is to express the role of adjunct cultures (types of Lactobacilli)
in the sensory properties of cheddar cheese, selection criteria, and the amount, and time
of adding adjunct cultures in the cheese-making process.
Deep Eutectic Solvents: Fundamental Aspect, Characterizations and Applications
Authors: Dangre Pankaj V. , Borase Harshada P. , Gunde Mahendra C. , Pethe Anil M. , Borkar Maheshkumar R.
Published: December 2022

Deep eutectic solvents (DESs) containing bioactive have been explored as potential choices
for therapeutic efficiency enhancement. DESs are regarded as superior compared to established solvents
owing to accessibility, storage conditions, synthesis, and low cost. As such, intensive research
has taken place in different disciplines, especially nutraceuticals, foods and pharmaceuticals. The applications
of DESs, especially in nutraceuticals and pharmaceutical delivery, have shown great promise.
Despite these different successes, the safety issues of these DESs need to be properly identified. A
safe mixture of DESs must be developed to take its broad range of advantages to the nutraceutical industry,
and, therefore, its nutraceutical applications can only be introduced if DESs are known to have
profiles of negligible or minimal toxicity. This review emphasizes the fundamental aspects needed to
have a better understanding of DESs. It covers the current prospects of DES, including types, properties,
formulation components and characterization methods. The several characterization methods,
viz., pH, density, refractive index, viscosity, surface tension, solubility, polarized optical microscopy,
x-ray diffraction studies, Fourier transforms infrared spectroscopy, and nuclear magnetic resonance
spectroscopy are also mentioned. Further, the promising applications of DESs in different nutraceutical
and pharmaceutical domains are highlighted.
Updating the criteria for assessing the state of the railway track according to the data of track measuring equipment
Authors: Zenzinov B. N. , Romen Y. S. , Krivolapov M. V.
Published: December 2022

Introduction. One of the consequences of the introduction of the Instructions for Assessing the Condition of the Rail Track (enacted on February 28, 2020 No. 436/r) was an increase in the number of newly detected deviations from the norm of track maintenance and their reassignment as malfunctions. As a result, the number of kilometres with limited train speeds has increased by up to 3 times, which may lead to significant losses in transportation and an increase in the cost of the immediate track maintenance.Materials and methods. Data from a special thoroughfare of a diagnostic complex along the operating lines of Russian Railways were used to analyse the actual distribution of types and magnitudes of malfunctions, the number and causes of the speed limits. The authors used computer simulations to determine the dynamic indicators of cars in accordance with the algorithm of the deterministic method for calculating the movement of cars along the railway track.Results. The consequences for assessing the state of the track from the standards specified in Instruction 436/r are analysed. The authors present the results of mathematical modelling of the rolling stock interaction with the track, confirming the feasibility of the proposed changes in the standards: increasing the permissible speeds of passenger trains, assessing the gauge widening in curved sections, clarifying the estimates of unbalanced acceleration.Discussion and conclusion. It is proposed to change a number of standards for assessing deviations from the norms of track maintenance in order to reduce the number of speed limits.
Uso de árvore de decisão para previsão de geração de viagens como alternativa ao método de classificação cruzada
Authors: M.N. Pianucci  , C.S. Pitombo
Published: December 2022

O objetivo do presente trabalho é apresentar a Árvore de Decisão (AD) para determinação de classes domiciliares, associadas a taxas de viagens como técnica alternativa ao método de Classificação Cruzada. A área de estudo é a cidade de São Carlos (São Paulo, Brasil) e os dados utilizados são provenientes da Pesquisa Origem-Destino (O/D), realizada na cidade em 2007/2008. O método possui sete etapas principais: (1) Escolha das variáveis relevantes ao estudo; (2) Aplicação da AD; (3) Obtenção das classes domiciliares; (4) Aplicação da RLM; (5) Estimativas de geração de viagens obtidas em 2; (6) Estimativas de geração de viagens obtidas em 4; (7) Comparação dos resultados obtidos em 5 e 6. Como resultados, a variável de maior importância (que melhor explica a variabilidade dos dados em relação à geração de viagens por domicílio) foi número de moradores no domicílio e, emambas as técnicas, os resultados foram muito similares. O uso de AD como ferramenta de auxílio na determinação de estratos para previsão de geração de viagens é adequado, possuindo boa acurácia na previsão do fenômeno de viagens domiciliares e utilizando como critério para determinação das classes medida de impureza (redução da variância).
Aprendizagem criativa e letramento digital: práticas inovadoras nos anos iniciais do ensino fundamental
Authors: De Paolis Marcela , Farias Pontes Deysiane
Published: December 2022

Este artigo objetiva investigar o letramento digital e a utilização de ferramentas digitais por professores dos anos iniciais do ensino fundamental durante o período de março a setembro de 2021, de modo a mapear novas práticas inovadoras e criativas de ensino. As práticas pesquisadas foram coletadas de um concurso institucional, o qual premiou atividades inovadoras no uso das tecnologias de informação e comunicação (TDICs). A análise documental e a pesquisa bibliográfica (Lüdke; André, 1986) foram as metodologias de pesquisa utilizadas. Para a compreensão acerca do letramento digital, foram utilizados os trabalhos de Magda Soares (2002, 2004) e Marcelo El Khouri Buzato (2006, 2009). Já para o diálogo sobre práticas inovadoras, foram consideradas as abordagens de Maria Isabel da Cunha (2016) e Fausto Camargo (2018). No que se refere à identificação da aprendizagem criativa, a análise se baseou nos estudos de Valeria C. Gomes Leal e Marcos Augusto F. Borges (2019), Mitchel Resnick (2020), entre outros. Concluiu-se que os docentes utilizaram, de forma inovadora, as TDICs no contexto da pandemia de covid-19, o que favoreceu a aprendizagem criativa e consolidou o letramento digital dos estudantes.
Thick Description and Embodied Analysis of Digital Visual Artefacts: The Visual Repertoire of #SisterIDoBelieveYou
Authors: Prieto Blanco Patricia , García-Mingo Elisa , Díaz Fernández Silvia
Published: December 2022

In this work, we explore the relationship between affect and the use of aesthetics by feminist digital activists to communicate their ideas and protest against sexual violence. Our focus, therefore, lies on the visual culture of digital protest. We consider visual artefacts a visual repertoire of protest (Jenzen et al., 2020, p. 420) that can both be articulated in a specific local context whilst simultaneously echoing global sentiments. In this paper, we analyse the visual repertoire of protest of Spanish feminist digital activism against sexual violence. To do so, we analysed 696 visual artefacts linked to the hashtag #HermanaYoSíTeCreo (#SisterIDoBelieveYou) shared on Twitter between May 1, 2018, and August 31, 2020. Our methodological framework incorporates a collaborative triangled analysis based on social semiotics (Ledin & Machin, 2018; Van Leeuwen, 2005), socio-hermeneutic analysis (Knoblauch & Schnettler, 2012; Serrano Pascual & Zurdo Alaguero, 2010), hashtag ethnography (Bonilla & Rose, 2015), and interpretative thick description (Geertz, 1973, pp. 3–30). Additionally, we also developed an ethnographic sensibility towards the corpus, which engaged us in a constant dialogue to overcome the positivist trend of data-driven visual digital analysis.
Our work here addresses the understanding of how visual discourses can create the affective unification of social media users (Stage, 2013) as a key feature of feminist politics and online activism (Keller et al., 2018). We analysed the use of visual artefacts by the "virtual" community of sisterhood and concluded that these processes served as a basis for (a) establishing distinctive while versatile visual branding; (b) weaving an affective community; (c) articulating the desire to connect and to gather through love, hope, outrage and disgust; and (d) linking past and present as well as geographically distant feminist struggles.
Association of Stress with Healthy Aging, the Role of Physical Activity
Authors: Figueira Helena Andrade , Figueira Olivia Andrade , Figueira Alan Andrade , Lyra da Silva Carlos Roberto , Figueira Joana Andrade , Martin Dantas Estelio Henrique
Published: December 2022

The World Health Organization attracted more attention to the positive effects of physical activity (PA) and the adverse effects of stress on the health of older people and, therefore, attracted a more significant number of practitioners. To verify the impact of PA on stress in older people. Observational and analytical research, composed of 690 older people of both genders residing in Brazil, present in street races (as participants or observers), who volunteered to respond to the research protocol consisting of sociodemographic profile, selected questions from the physical activity inventory for the older people, Baecke-Old, and the Perceived Stress Scale (PSS). The sample of active older people, 84.35% practitioners of physical activity and 75.4% with higher education, revealed mild-moderate stress at 83.77%, with mean = 51.68%, standard deviation = 12.33%. There was correspondence between PA and stress (p < 0.05). Older people practitioners of physical activity with a higher education level have a mild-moderate stress level. Considering the aging of societies worldwide, with the tendency of older people to present a mild-moderate level of stress, it is suggested that measures be taken for greater vigilance about the stress of older people.
Predictive Factors of Response to Mindfulness-Based Cognitive Therapy (Mbct) for Patients with Depressive Symptoms: The Machine Learning’s Point of View
Authors: dethoor manon , vialatte françois , martinelli marion , peri pauline , lançon christophe , TROUSSELARD Marion
Published: December 2022

While there is abundant literature on the benefits of Mindfulness-Based Interventions (MBI), data about factors associated with their Efficiency are scarce. Our study attempts to determine the moderators of efficacy and adherence in Mindfulness-Based Cognitive Therapy (MBCT) with a machine learning analysis. Seventy-six psychiatric outpatients at “university hospital mental health service” had a prescription for MBCT from their referring psychiatrist. They suffer from various psychiatric illnesses with depressive symptoms. They completed a battery of clinical, mindfulness, and psychological functioning self-report questionnaires before and after the MBCT intervention of 8 sessions. Changes (after minus before) in scores were used for efficacy. Scores before MBCT were used to study the adherent profile (8 sessions of MBCT) versus non-adherent patients (stopping MBCT before the eight sessions). For efficacy and adherence profiles, machine learning analysis based on the support vector machine (SMV) method was applied to complement classical statistical analyses. Results: For efficacy factors, the SVM analysis finds a two-dimensional profile of patients. The patients for whom MBCT is most effective are patients with a high Beck score (>25) and high trait mindfulness (FFMQ >90). The percentage of misclassified validation examples is 24.6 (LOO = 75.4). The model's sensitivity is 79.3%, and the specificity is 71.9%. For adherence factors, a three-dimensional model is found. The patients who perform the 8 sessions of the MBCT have a profile with high or low trait mindfulness, high or low bodily dissociation, and low self-compassion. The percentage of misclassified validation examples is 37.3 (LOO = 62.7). The model's sensitivity is 48.4%, and the specificity is 71.9%. These results provide preliminary evidence that the predictive power of machine learning may allow the designing of standard patient profiles, which can contribute to 3 more personalized care for patients with symptoms of depression and anxiety. Also, including more psychoeducation in MBCT programs can maximize clinical benefits and adherence to this therapy. However, further studies are needed to explore this topic in more detail.
The Potential for Using Extended Reality Technology in Interdisciplinary Case Discussions and Case Planning in Stereotactic Radiosurgery: Proof-of-Concept Usability Study
Authors: Chidambaram Swathi , Palumbo Maria Chiara , Stifano Vito , McKenna John , Redaelli Alberto , Olivi Alessandro , Apuzzo Michael , Pannullo Susan
Published: December 2022

Background

Extended reality (XR) is a term that captures a variety of techniques, such as augmented reality (AR) and mixed reality (MR), which allow users to interact with virtual models in real time. This technology has an emerging role in several applications within neurosurgery. XR can be useful in enhancing how radiosurgical cases are planned. Multidisciplinary team (MDT) review is an essential part of the radiosurgery case planning process; during case discussions, patient images are reviewed, usually in 2D or 3D modifications. The current commercially available platforms for this review need improvement.

Objective

We describe a novel visualization application, titled “NeuroVis” by our development team, which uses an XR Microsoft HoloLens headset to provide an interactive 3D visualization of a patient’s neuroanatomy in stereotactic surgery (SRS) case planning discussions.

Methods

We present examples of 6 common radiosurgery indications to demonstrate the utility of NeuroVis to solve common visualization hurdles in MDTs.

Results

The utility of NeuroVis is demonstrated through 6 common brain tumor SRS cases as a proof-of-concept illustration of the utility of NeuroVis to enhance radiosurgery case discussion by improving visualization of the standard neuroimaging used in radiosurgery treatment planning by MDTs.

Conclusions

The NeuroVis application provides several interactive features that produce an enhanced ability to place participating members of an interdisciplinary treatment team on the same visualization plane. This technology, by facilitating team discussions and case review, has the potential to improve the efficiency, efficacy, and safety of radiosurgery treatment planning and, as a result, to optimize patient care.
Swasthya Pahal (Health for All) Using a Sustainable, Multisector, Accessible, Affordable, Reimbursable, and Tailored Informatics Framework in Rural and Urban Areas of Chennai, Tamil Nadu: Protocol for a Quantitative Study
Authors: Joshi Ashish , Surapaneni Krishna Mohan , Grover Ashoo , Kaur Harpreet , Saggu Sofia Rani , Oliveira Doilyn
Published: December 2022

Background

Noncommunicable diseases (NCDs) require a longer period of care, for which health care systems must acquire technologically advanced solutions to enhance patient care. Swasthya Pahal (health for all) is an innovative, interactive, multilingual, stand-alone, internet-enabled computer-based program that aims to improve the self-management of NCDs.

Objective

This study aims to enhance the self-management of chronic NCDs (diabetes, hypertension, high cholesterol, and obesity) by determining the usefulness, acceptance, and effectiveness of the Swasthya Pahal program in hospital and community settings in both rural and urban areas of Chennai, Tamil Nadu. This objective can be met by generating risk factor profiles of individuals enrolled and enhancing their self-management of NCDs using a portable health information kiosk that uses the Sustainable, Multisector, Accessible, Affordable, Reimbursable, and Tailored (SMAART) model.

Methods

A quantitative study will be conducted on a convenient sample of 2800 individuals from selected hospital and community settings in rural (n=1400) and urban areas (n=1400) in Chennai, Tamil Nadu. Data will be collected on sociodemographics, health behaviors, and clinical status, as well as knowledge, attitudes, and practices. Objective assessments such as weight, blood pressure, and random blood sugar levels will be measured. In addition, the usefulness, acceptance, and effectiveness of the Swasthya Pahal program will be determined.

Results

Results will be summarized using descriptive analysis. Appropriate bivariate and multivariate regression analysis will be performed to determine the predictors of the outcome variables of usefulness, acceptance, and effectiveness of Swasthya Pahal in wider settings. All analyses will be performed using SAS (version 9.1; SAS Institute), and the results will be reported as 95% CI values and P<.05.

Conclusions

The study proposes to enhance the self-management of NCDs in both rural and urban community settings through the implementation of the Swasthya Pahal program based on the SMAART informatics framework. The study aims to understand the implementation, acceptability, and usability of Swasthya Pahal among a diverse sample of people in urban and rural settings.

International Registered Report Identifier (IRRID)

PRR1-10.2196/39950
Charting a Course for Smartphones and Wearables to Transform Population Health Research
Authors: Dixon William G , van der Veer Sabine N , Ali Syed Mustafa , Laidlaw Lynn , Dobson Richard J B , Sudlow Cathie , Chico Tim , MacArthur Jacqueline A L , Doherty Aiden
Published: December 2022

The use of data from smartphones and wearable devices has huge potential for population health research, given the high level of device ownership; the range of novel health-relevant data types available from consumer devices; and the frequency and duration with which data are, or could be, collected. Yet, the uptake and success of large-scale mobile health research in the last decade have not met this intensely promoted opportunity. We make the argument that digital person-generated health data are required and necessary to answer many top priority research questions, using illustrative examples taken from the James Lind Alliance Priority Setting Partnerships. We then summarize the findings from 2 UK initiatives that considered the challenges and possible solutions for what needs to be done and how such solutions can be implemented to realize the future opportunities of digital person-generated health data for clinically important population health research. Examples of important areas that must be addressed to advance the field include digital inequality and possible selection bias; easy access for researchers to the appropriate data collection tools, including how best to harmonize data items; analysis methodologies for time series data; patient and public involvement and engagement methods for optimizing recruitment, retention, and public trust; and methods for providing research participants with greater control over their data. There is also a major opportunity, provided through the linkage of digital person-generated health data to routinely collected data, to support novel population health research, bringing together clinician-reported and patient-reported measures. We recognize that well-conducted studies need a wide range of diverse challenges to be skillfully addressed in unison (eg, challenges regarding epidemiology, data science and biostatistics, psychometrics, behavioral and social science, software engineering, user interface design, information governance, data management, and patient and public involvement and engagement). Consequently, progress would be accelerated by the establishment of a new interdisciplinary community where all relevant and necessary skills are brought together to allow for excellence throughout the life cycle of a research study. This will require a partnership of diverse people, methods, and technologies. If done right, the synergy of such a partnership has the potential to transform many millions of people’s lives for the better.
The Development of Tubular Photobioreactor for Microalgae Cultivation
Authors: Kunopagarnwong Varit , Srinophakun Thongchai Rohitatisha
Published: December 2022

In a tubular photobioreactor, microalgae cells obscure one another (Self-shading), leading to the microalgae at the bottom of the tube getting less light. The objective of this research was to design and develop Tubular Photobioreactor with 93.5 liters for microalgae cultivation. The experiments had two steps. The first step was designing the solar receiver by inserting the fin into each tube wall as follows: 12-34, 1-2-3-4, 1234, and 13-24. Then, FLUENT software was used to simulate flow behavior inside the tube by Computational Fluid Dynamics by observing the pressure drop, the amount of energy consumption, and the swirling velocity to select the best fin-type. The best fin-type with the growth rate equation is introduced in the next step to simulate the microalgae's growth and movement using the user-defined function technique. The comparison of a tubular photobioreactor is investigated between fin and without fin by observing biomass production. The results showed that algae's optimum inlet velocity is 0.15 meters per second with the tubes containing fin-type 13-24. When simulating the growth behavior of microalgae, results show that the tubes without fins had lower biomass content than the 13-24 fin-type, which were 0.675 and 0.806 grams per liter, respectively, because the 13-24 fin-type will make well microalgae distribution leading to increase the light distribution too. Tubular photobioreactor fins type 13-24 had more biomass production, up to 19.4 percent.
Effect of Carrier Agents and Operational Parameters on the Physical Quality of Spray-Dried Tomato Powder: A Review
Authors: Anisuzzaman S M , Joseph Collin G. , Nga Janice L. H. , Ismail Fatin Nadiah
Published: December 2022

Tomatoes are one of the most frequently consumed crops in the world, and they can be cultivated all year using present production methods. Tomatoes are produced for either manufacturing tomato paste, tomato pulp, tomato sauce, and ketchup or consumed as fresh fruit. However, excessive moisture levels in tomatoes generally result in increased water activity that promotes quality degradation and increases enzymatic activity, which leads to microbial growth. Therefore, the spray drying method is used to produce dried food powder, which may reduce postharvest losses while adding value to the raw product. The purpose of the paper is to review scientific research on the influence of carrier agents and operational parameters of spray-drying fruit extracts on physicochemical qualities such as moisture content, hygroscopicity, solubility, bulk density, water activity, and color difference. The current paper reviews the various formulation and process factors that impact the physicochemical characteristics of tomato powder microparticles produced by spray drying in order to find the optimum parameters to produce tomato powders with a high and effective product yield with improved powder qualities.
Comparison of Maseration and Sonication Method on Flavonoid Extraction from Mango Leaves: Effect of Solvent Ratio
Authors: Sari Alifiana Permata , Amanah Nur Layli , Wardatullathifah Awalia , Nugroho Agung
Published: December 2022

Mango leaf extract has proven to contain flavonoids that serve as antioxidants. In this study, a comparison between traditional maceration and sonication on flavonoid extraction from mango leaf was investigated. The various ratios of ethanol and acetone were utilized as solvents (1:5, 1:10, and 1:15). The sonication process, which uses an ultrasonic cleaning bath set at 40 oC, takes 30 minutes as contrasted to the maceration procedure of 36 hours treatment at room temperature. The flavonoid test using aluminum (III) chloride (AlCl3) colorimetric technique shows that acetone provides greater solvent power than ethanol. According to this study, the optimal ratios for the maceration and sonication procedures are 1:10 and 1:15, respectively. The maceration process resulted in the optimum extract of 0.186 mgQE/g dry leaves. Meanwhile, using a 1:15 acetone solvent ratio and the sonication method, the highest concentration of flavonoid components was discovered, reaching 0.143 mgQE/g dry material with 54 times shorter time.
Combined Spermacoce radiata and Hypselodelphys poggeana Extract (CESH) Protect against Oxidative Stress and Enhances Haematological Parameters in Benign Prostatic Hyperplasia-induced Rats
Authors: Uroko Robert Ikechukwu , Awah Favour Matthew , Aguwamba Chinedu , Uche Mercylyn Ezinne , Obiwuru Ikenna , Aaron Chinomso Friday , Ofoezie Ezichi Favour
Published: December 2022

This study investigated the therapeutic effect of a combined extract of Spermacoce radiata and Hypselodelphys poggeana (CESH) on oxidative markers and haematological parameters in benign prostatic hyperplasia (BPH) induced rats. The study adopted five groups containing equal numbers of rats (n = 6), including normal control, BPH control, Finasteride control, BPH-induced rats treated with 200 mg/kg CESH, and BPH-induced rats treated with 600 mg/kg CESH. The rats were induced BPH by the subcutaneous administration of a 5 mg/kg testosterone propionate injection. At the same time, treatment finasteride and CESH to the respective groups were given orally 60 minutes after the BPH induction for 28 uninterrupted days. The induction of BPH with testosterone propionate injection caused a significant reduction in the serum levels of haematological parameters, including haemoglobin (Hb), packed cell volume (PCV), red blood cells (RBC), and platelet counts of the BPH control compared with normal control. The glutathione (GSH) concentration, glutathione peroxidase (GPx), superoxide dismutase (SOD), glutathione S-transferase, and catalase activities decreased significantly in the BPH control relative to the normal control. The BPH control had elevated white blood cell (WBC), and malondialdehyde (MDA) concentrations contrary to the high WBC and MDA in the normal control and CESH treated BPH induced rats, respectively. Conversely, the Hb, PCV, platelet count, GPx, SOD, catalase, GST, and GSH increased significantly in the finasteride and CESH-treated BPH-induced rats, respectively, compared to the BPH control. These findings show that CESH attenuates adverse effects of BPH on antioxidant parameters and oxidative markers, which may prevent BPH progression.
Characterization and Antioxidant Activity of Banana Peels, Pineapple Peels, and Combination Extracts of both Peels as Raw Materials in the Development of Hard Candy
Authors: Apridamayanti Pratiwi , Kurniawan Hadi , Nugraha Fajar , Fajriaty Inarah - , Nurbaeti Siti Nani , Pratiwi Liza
Published: December 2022

Kepok banana and pineapple are horticultural commodities found in West Kalimantan. The two fruits are generally used as processed foods such as fried bananas and pineapple jam. The use of fruit as food often leaves the peel as a by-product, which can produce waste twice the weight of the food consumed. Meanwhile, waste utilization is an innovation in food processing into functional products which are developed into hard candy. Therefore, this research aims to the specific and non-specific characterization of raw materials for making candy, namely the combination of banana and pineapple peel extract (KP-KN). The characterization is organoleptic tests on the content of ethanol-soluble and water-soluble extracts. The Total phenolic content was determined by the Follin ciocalticeu method with UV/Vis spectrophotometry. Furthermore, antioxidant activity tests with DPPH and FRAP methods using UV/Vis spectrophotometry and ELISA to determine antioxidant activity. The mineral content was observed using the molybdate vandalate method with UV/vis spectrophotometry and ICP-MS, Heavy metal contamination using the ICP-MS tool, and microbial contamination using the plate method. Moreover, the infundation process was carried out on banana and pineapple peels, and the results were evaporated using a food dehydrator to obtain a combination extract. The results showed that the organoleptically KP-KN combination extract had a bitter taste, pineapple smells, 15.57% ash content, ethanol soluble extract content of 55.10%, and 47.99% water-soluble extract. Also, the total phenolic of 6.22 g/Kg, as well as the mineral content of Potassium (K), Calcium (Ca), Iron (Fe), Magnesium (Mg), Zinc (Zn), and Phosphorus (P), which were 47.23 g/Kg, 291.43 mg/Kg, <1x10-6 g/Kg, 2.59x10-3 g/Kg, and 2.38 g/Kg, respectively. Meanwhile, the heavy metal and bacterial contamination test showed that Arsenic (As), Sn, Mercury (Hg), and lead (Pb) were <1x10-6 g/Kg and Cadmium (Cd) was 0.0293. In the microbial contamination test with bacterial components including the ALT test, a value of 4.83 x 103 cfu/g was found, and there was no contamination from E.coli, mold, and yeast bacteria, DPPH and FRAP methods showed antioxidant activity combination extract banana peels and pineapple peels with values of 1390.96±2.83 mg/L and 4542.81±1.10 mg/L compare antioxidant activity of ascorbic acid as standard is 2.13 mg/L and 4.83 mg/L. The test with the KP-KN combined extract can be used as a raw material for making hard candy because it contains minerals needed by the body, meets the safety and quality requirements of traditional medicines, and has antioxidant activity in vitro.