bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S1 from Identification of a ΔNp63-Dependent Basal-Like A Subtype-Specific Transcribed Enhancer Program (B-STEP) in Aggressive Pancreatic Ductal Adenocarcinoma
Authors: Wang Xin , Kutschat Ana P. , Aggrey-Fynn Joana , Hamdan Feda H. , Graham Rondell P. , Wixom Alexander Q. , Souto Yara , Ladigan-Badura Swetlana , Yonkus Jennifer A. , Abdelrahman Amro M. , Alva-Ruiz Roberto , Gaedcke Jochen , Ströbel Philipp , Kosinsky Robyn Laura , Wegwitz Florian , Hermann Patrick , Truty Mark J. , Siveke Jens T. , Hahn Stephan A. , Hessmann Elisabeth , Johnsen Steven A. , Najafova Zeynab
Published: September 2023

Defining the basal-like A-specific enhancer landscape in PDAC
Fig. S7 from Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis
Authors: Mohammed Sabira , Thadathil Nidheesh , Ohene-Marfo Phoebe , Tran Albert L. , Van Der Veldt Michael , Georgescu Constantin , Oh Sangphil , Nicklas Evan H. , Wang Dawei , Haritha Nair Hariprasad , Luo Wenyi , Janknecht Ralf , Miller Benjamin F. , Wren Jonathan D. , Freeman Willard M. , Deepa Sathyaseelan S.
Published: September 2023

Figure S7 shows western blots for p-AKT/AKT, p-S6/S6, b tubulin, p-ERK/ERK, P-p-38/p-38, b catenin, p62 and b tubulin
Fig. S5 from Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis
Authors: Mohammed Sabira , Thadathil Nidheesh , Ohene-Marfo Phoebe , Tran Albert L. , Van Der Veldt Michael , Georgescu Constantin , Oh Sangphil , Nicklas Evan H. , Wang Dawei , Haritha Nair Hariprasad , Luo Wenyi , Janknecht Ralf , Miller Benjamin F. , Wren Jonathan D. , Freeman Willard M. , Deepa Sathyaseelan S.
Published: September 2023

Figure S5 shows images of liver nodules, transcript levels of AFP
Fig. S2 from Absence of Either Ripk3 or Mlkl Reduces Incidence of Hepatocellular Carcinoma Independent of Liver Fibrosis
Authors: Mohammed Sabira , Thadathil Nidheesh , Ohene-Marfo Phoebe , Tran Albert L. , Van Der Veldt Michael , Georgescu Constantin , Oh Sangphil , Nicklas Evan H. , Wang Dawei , Haritha Nair Hariprasad , Luo Wenyi , Janknecht Ralf , Miller Benjamin F. , Wren Jonathan D. , Freeman Willard M. , Deepa Sathyaseelan S.
Published: September 2023

Figure S2 shows body weight changes, liver weight changes, Transcript levels of Il1b and H&E staining for showing KC population
Supplementary Figure Legends 1-6 from Oncostatin-M and OSM-Receptor Feed-Forward Activation of MAPK Induces Separable Stem-like and Mesenchymal Programs
Authors: Polak Kelsey L. , Tamagno Ilaria , Parameswaran Neetha , Smigiel Jacob , Chan E. Ricky , Yuan Xueer , Rios Brenda , Jackson Mark W.
Published: September 2023

Supplementary Figure Legends 1-6
Supplementary Table 2 from CCRL2 Expression by Specialized Lung Capillary Endothelial Cells Controls NK-cell Homing in Lung Cancer
Authors: Sozio Francesca , Schioppa Tiziana , Laffranchi Mattia , Salvi Valentina , Tamassia Nicola , Bianchetto-Aguilera Francisco M. , Tiberio Laura , Bonecchi Raffaella , Bosisio Daniela , Parmentier Marc , Bottazzi Barbara , Leone Roberto , Russo Eleonora , Bernardini Giovanni , Garofalo Stefano , Limatola Cristina , Gismondi Angela , Sciumè Giuseppe , Mantovani Alberto , Del Prete Annalisa , Sozzani Silvano
Published: September 2023

Supplementary Table 2
Supplementary Figures from AXL Inhibition Improves the Antitumor Activity of Chimeric Antigen Receptor T Cells
Authors: Sakemura R. Leo , Hefazi Mehrdad , Cox Michelle J. , Siegler Elizabeth L. , Sinha Sutapa , Hansen Michael J. , Stewart Carli M. , Feigin Jennifer M. , Manriquez Roman Claudia , Schick Kendall J. , Can Ismail , Tapper Erin E. , Horvei Paulina , Adada Mohamad M. , Bezerra Evandro D. , Kankeu Fonkoua Lionel Aurelien , Ruff Michael W. , Forsman Cynthia L. , Nevala Wendy K. , Boysen Justin C. , Tschumper Renee C. , Grand Cory L. , Kuchimanchi Kameswara R. , Mouritsen Lars , Foulks Jason M. , Warner Steven L. , Call Timothy G. , Parikh Sameer A. , Ding Wei , Kay Neil E. , Kenderian Saad S.
Published: September 2023

Supplementary Figures S1-S17
Supplementary Figure Legends from AXL Inhibition Improves the Antitumor Activity of Chimeric Antigen Receptor T Cells
Authors: Sakemura R. Leo , Hefazi Mehrdad , Cox Michelle J. , Siegler Elizabeth L. , Sinha Sutapa , Hansen Michael J. , Stewart Carli M. , Feigin Jennifer M. , Manriquez Roman Claudia , Schick Kendall J. , Can Ismail , Tapper Erin E. , Horvei Paulina , Adada Mohamad M. , Bezerra Evandro D. , Kankeu Fonkoua Lionel Aurelien , Ruff Michael W. , Forsman Cynthia L. , Nevala Wendy K. , Boysen Justin C. , Tschumper Renee C. , Grand Cory L. , Kuchimanchi Kameswara R. , Mouritsen Lars , Foulks Jason M. , Warner Steven L. , Call Timothy G. , Parikh Sameer A. , Ding Wei , Kay Neil E. , Kenderian Saad S.
Published: September 2023

Supplementary Figure Legends
Supplementary Figures from Host Interactions with Engineered T-cell Micropharmacies
Authors: Bourne Christopher M. , Wallisch Patrick , Dacek Megan M. , Gardner Thomas J. , Pierre Stephanie , Vogt Kristen , Corless Broderick C. , Bah Mamadou A. , Romero-Pichardo Jesus E. , Charles Angel , Kurtz Keifer G. , Tan Derek S. , Scheinberg David A.
Published: September 2023

Supplementary Figures S1-S15
Supplementary Figures from Clec4A4 Acts as a Negative Immune Checkpoint Regulator to Suppress Antitumor Immunity
Authors: Uto Tomofumi , Fukaya Tomohiro , Mitoma Shuya , Nishikawa Yotaro , Tominaga Moe , Choijookhuu Narantsog , Hishikawa Yoshitaka , Sato Katsuaki
Published: September 2023

Supplementary Figures
Supplementary Table 2 from Enhancing CAR T-cell Therapy Using Fab-Based Constitutively Heterodimeric Cytokine Receptors
Authors: Righi Matteo , Gannon Isaac , Robson Matthew , Srivastava Saket , Kokalaki Evangelia , Grothier Thomas , Nannini Francesco , Allen Christopher , Bai Yuchen V. , Sillibourne James , Cordoba Shaun , Thomas Simon , Pule Martin
Published: September 2023

Supplementary Table S2. Top 50 up-regulated GSEA pathways.
Supplementary Figures from HER2Δ16 Engages ENPP1 to Promote an Immune-Cold Microenvironment in Breast Cancer
Authors: Attalla Sherif Samer , Boucher Jonathan , Proud Hailey , Taifour Tarek , Zuo Dongmei , Sanguin-Gendreau Virginie , Ling Chen , Johnson Gabriella , Li Vincent , Luo Robin B. , Kuasne Hellen , Papavasiliou Vasilios , Walsh Logan A. , Barok Mark , Joensuu Heikki , Park Morag , Roux Philippe P. , Muller William J.
Published: September 2023

Supp. Figures S1-20
Data from Next-Generation JAK2 Inhibitors for the Treatment of Myeloproliferative Neoplasms: Lessons from Structure-Based Drug Discovery Approaches
Authors: Nair Pramod C. , Piehler Jacob , Tvorogov Denis , Ross David M. , Lopez Angel F. , Gotlib Jason , Thomas Daniel
Published: September 2023

Abstract
Selective inhibitors of Janus kinase (JAK) 2 have been in demand since the discovery of the JAK2 V617F mutation present in patients with myeloproliferative neoplasms (MPN); however, the structural basis of V617F oncogenicity has only recently been elucidated. New structural studies reveal a role for other JAK2 domains, beyond the kinase domain, that contribute to pathogenic signaling. Here we evaluate the structure-based approaches that led to recently-approved type I JAK2 inhibitors (fedratinib and pacritinib), as well as type II (BBT594 and CHZ868) and pseudokinase inhibitors under development (JNJ7706621). With full-length JAK homodimeric structures now available, superior selective and mutation-specific JAK2 inhibitors are foreseeable.
Significance:
The JAK inhibitors currently used for the treatment of MPNs are effective for symptom management but not for disease eradication, primarily because they are not strongly selective for the mutant clone. The rise of computational and structure-based drug discovery approaches together with the knowledge of full-length JAK dimer complexes provides a unique opportunity to develop better targeted therapies for a range of conditions driven by pathologic JAK2 signaling.
Cerebral Salt Wasting Syndrome pada Pasien dengan Infark Serebri : Sebuah Laporan Kasus
Authors: Hapsari Aulia , Prakoso Budi
Published: September 2023

Pendahuluan: Hiponatremia merupakan kondisi yang sering terjadi di rumah sakit, pada pasien dengan gangguan sistem saraf pusat sering menyebabkan hiponatremia oleh SIADH (Syndrome Inappropriate Antidiuretic Hormone) dan CSWS (cerebral salt wasting syndrome).

Laporan Kasus Wanita usia 71 tahun datang dengan keluhan tidak sadar 12 jam SMRS, Riwayat jatuh dan kepala terbentur lantai 3 hari SMRS. Pasien memiliki Riwayat hipertensi dan mengkonsumsi amlodipine 5 mg. Pasien tampak dehidrasi dan didapatkan produksi urin 3000cc/hari dengan hiponatremia berat. Pasien didiagnosis dengan CSWS dan mendapatkan hipertonik salin serta steroid. Pasien berespon positif terhadap terapi yang diberikan ditandai dengan meningkatnya kadar sodium serum secara berkala dan pulihnya kesadaran.

Diskusi: CSWS adalah kondisi hiponatremia dan dehidrasi yang disebabkan cedera kepala,infark serebri,dan gangguan neurologi lainya. Penyebab CSWS cenderung dipengaruhi oleh peptide natriuretic, peptida ini tidak hanya dikeluarkan pada kondisi gagal jantung namun pada kondisi kerusakan saraf pusat.

Kesimpulan: Pada laporan kasus ini, Wanita usia 71 tahun yang terdiagnosis CSWS dikarenakan infark serebri berespon positif dengan terapi hipertonik saline dan steroid. Penyebab utama hiponatremi yaitu CSWS dan SIADH yang didapatkan dari anamnesis hingga pemeriksaan penunjang agar dapat memberikan terapi yang holistik dan komprehensif.
O Teatro Lambe-Lambe e seu espaço-tempo do encontro
Authors: Cobra Pedro
Published: September 2023

Reflexões acerca das potências do Teatro Lambe-Lambe em criar espaços de intimidade e explorar o tempo das memórias, dos afetos e da idiossincrasia por meio de miudezas. A partir da investigação artística junto à Cia. PlastikOnírica, o autor apresenta um olhar sobre diferentes aspectos do encontro promovido pelo Teatro Lambe-Lambe entre artistas, durante o processo criativo, do encontro com o ambiente urbano onde se coloca para a apresentação e do encontro espontâneo com o público singularizado por meio de um espetáculo de curta duração.
Recorrências locais de tumores de glândulas salivares em uma população brasileira
Authors: Lucena Maria Eduarda de Arruda , Almeida Hittalo Carlos Rodrigues de , Silva Leorik Pereira da , Silveira Márcia Maria Fonseca da , Sobral Ana Paula Veras
Published: September 2023

Objetivo: Identificar a presença de recidiva após o ato cirúrgico de pacientes diagnosticados com tumor de glândula salivar. Métodos: Os dados foram coletados no Hospital de Câncer de Pernambuco, Recife, Brasil, através de um formulário padrão com base nos prontuários clínicos. Foram coletadas informações sobre idade, sexo, tipo de tumor de glândula salivar, recidiva local, estágio, local primário e tipo de tratamento. Os dados foram descritivos e analisados com nível de significância de 5% (p < 0,05). Resultados: Dos 55 prontuários que fizeram parte da amostra do estudo, 51% correspondem ao sexo masculino. A média de idade geral foi de 55 anos, com a faixa etária variando entre 13 e 90 anos. O adenocarcinoma (SOE) foi o mais prevalente (n = 17), seguido do carcinoma adenoide cístico (CAC) (n = 14; 25,5%). Dentre todos os sítios, o mais comum foi a glândula parótida (n = 29; 53%). 61,8% (n = 34) dos pacientes não apresentaram metástase à distância. Entretanto, 38,18% (n = 21) apresentaram, sendo 14,55% (n = 8) com metástase em osso. 34,55% (n = 19) dos pacientes tiveram recidiva com apenas 1 ano após o diagnóstico. A neoplasia com maior taxa de recidiva foi o SOE, apresentando 30,91% (n = 17); o CAC foi o segundo maior com 25,45% (n = 14). Conclusão: O sexo masculino perfez a maioria dos casos; houve um predomínio de acometimento na glândula parótida; as neoplasias mais frequentes foram o SOE e o CAC; metástase à distância ocorreu em 38,18% (n = 21), sendo o osso o local mais acometido; a cirurgia com radioterapia adjuvante (n = 15) foi o tratamento de eleição.
Feasibility of Simultaneous Quantification of Myocardial and Renal Perfusion With Cardiac Positron Emission Tomography
Authors: Brown Jenifer M. , Park Mi-Ae , Kijewski Marie Foley , Weber Brittany N. , Yang Yihe , Martell Laurel , Perillo Anna , Barrett Leanne , Parks Sean , Hainer Jon , Dorbala Sharmila , Blankstein Ron , Di Carli Marcelo F.
Published: September 2023

BACKGROUND:

Given the central importance of cardiorenal interactions, mechanistic tools for evaluating cardiorenal physiology are needed. In the heart and kidneys, shared pathways of neurohormonal activation, hypertension, and vascular and interstitial fibrosis implicate the relevance of systemic vascular health. The availability of a long axial field of view positron emission tomography (PET)/computed tomography (CT) system enables simultaneous evaluation of cardiac and renal blood flow.

METHODS:

This study evaluated the feasibility of quantification of renal blood flow using data acquired during routine, clinically indicated
13
N-ammonia myocardial perfusion PET/CT. Dynamic PET image data were used to calculate renal blood flow. Reproducibility was assessed by the intraclass correlation coefficient among 3 independent readers. PET-derived renal blood flow was correlated with imaging and clinical parameters in the overall cohort and with histopathology in a small companion study of patients with a native kidney biopsy.

RESULTS:

Among 386 consecutive patients with myocardial perfusion PET/CT, 296 (76.7%) had evaluable images to quantify renal perfusion. PET quantification of renal blood flow was highly reproducible (intraclass correlation coefficient 0.98 [95% CI, 0.93–0.99]) and was correlated with the estimated glomerular filtration rate (
r
=0.64;
P
<0.001). Compared across vascular beds, resting renal blood flow was correlated with maximal stress myocardial blood flow and myocardial flow reserve (stress/rest myocardial blood flow), an integrated marker of endothelial health. In patients with kidney biopsy (n=12), resting PET renal blood flow was strongly negatively correlated with histological interstitial fibrosis (
r
=−0.85;
P
<0.001).

CONCLUSIONS:

Renal blood flow can be reliably measured from cardiac
13
N-ammonia PET/CT and allows for simultaneous assessment of myocardial and renal perfusion, opening a potential novel avenue to interrogate the mechanisms of emerging therapies with overlapping cardiac and renal benefits.
Impact of Preprocedural Diastolic Blood Pressure on Outcomes in Patients Undergoing Percutaneous Coronary Intervention
Authors: Warren Josephine , Dinh Diem , Brennan Angela , Tan Christianne , Dagan Misha , Stehli Julia , Clark David J. , Ajani Andrew E. , Reid Christopher M. , Sebastian Martin , Oqueli Ernesto , Freeman Melanie , Stub Dion , Duffy Stephen J. ,   On behalf of the Melbourne Interventional Group Investigators
Published: September 2023

BACKGROUND:

Recent US guidelines recommend lower blood pressure (BP) targets in hypertension, but aggressive lowering of diastolic BP (DBP) can occur at the expense of myocardial perfusion, particularly in the presence of coronary artery disease. We sought to establish the long-term impact of low DBP on mortality among patients undergoing percutaneous coronary intervention with well-controlled systolic BP.

METHODS:

We analyzed data from 12 965 patients undergoing percutaneous coronary intervention between 2009 and 2018 from the Melbourne Interventional Group registry who had a preprocedural systolic BP of ≤140 mm Hg. Patients with ST-elevation myocardial infarction, cardiogenic shock, and out-of-hospital arrest were excluded. Patients were stratified into 5 groups according to preprocedural DBP: <50, 50 to 59, 60 to 69, 70 to 79, and ≥80 mm Hg. The primary outcome was long-term, all-cause mortality. Mortality data were derived from the Australian National Death Index.

RESULTS:

Patients with DBP<50 mm Hg were older with higher rates of diabetes, renal impairment, prior myocardial infarction, left ventricular dysfunction, peripheral and cerebrovascular disease (all
P
<0.001). Patients with DBP<50 mm Hg had higher 30-day (2.5% versus 0.7% for the other 4 quintiles;
P
<0.0001) and long-term mortality (median, 3.6 years; follow-up, 29% versus 11%;
P
<0.0001). Cox-regression analysis revealed that DBP<50 mm Hg was an independent predictor of long-term mortality (hazard ratio [HR], 1.55 [95% CI, 1.20–2.00];
P
=0.001).

CONCLUSIONS:

In patients with well-controlled systolic BP undergoing percutaneous coronary intervention, low DBP (<50 mm Hg) is an independent predictor of long-term mortality.
Penicillium thailandense (Aspergillaceae, Eurotiales), a new species isolated from soil in northern Thailand
Authors: KHUNA SURAPONG , KUMLA JATURONG , THITLA TANAPOL , HONGSANAN SINANG , LUMYONG SAISAMORN , SUWANNARACH NAKARIN
Published: September 2023

A new species of soil fungi, described herein as Penicillium thailandense, was isolated from soil samples of deciduous dipterocarp forest in Lamphun Province, Thailand. This species was identified by using combination of morphological characteristics and molecular analyses. Morphologically, P. thailandense is similar to P. sanjayi, but it can be distinguished by having monoverticillate and biverticillate conidiophores, white to dark gray sclerotia, and larger conidia. Multi-gene phylogenetic analyses of a combination of the internal transcribed spacer (ITS) of ribosomal DNA, β-tubulin (BenA), calmodulin (CaM), and RNA polymerase II second largest subunit (rpb2) genes revealed that P. thailandense belongs to the Penicillium section Citrina and is distinct from other known species. This paper provides a description, illustrations, and phylogenetic tree of this novel species.
Pilularia ethiopica (Pteridophyta, Marsileaceae), a new species of pillwort from the tropical African mountains of Ethiopia
Authors: FISCHER EBERHARD , KILLMANN DOROTHEE , ACKERMANN MARKUS , YESHITELA KUMELACHEW
Published: September 2023

Pilularia ethiopica is described as a new species from the highlands of Ethiopia. It is similar to P. americana, P. bokkeveldensis, and P. dracomontana, but differs from P. americana in the shorter fronds, the smaller sporocarp, the shorter pedicel, and the subterranean sporocarps at maturity. It differs from P. bokkeveldensis in the obvious circinate vernation, the smaller sporocarps, the shorter pedicel, and the subterranean sporocarps at maturity. It differs from P. dracomontana in the longer fronds, the obvious circinate vernation, the longer pedicel, and the only partly submerged habit.
Aspidistra shimentaiensis (Asparagaceae), a new species from Guangdong, China
Authors: PENG CAI-XIA , DAI KE-YUAN , LI YUAN-QIU , TONG YI-HUA , LIN CHUN-RUI
Published: September 2023

Aspidistra shimentaiensis, a new species of Asparagaceae from Guangdong, southern China, is described and illustrated. The new species is similar to A. nankunshanensis, but differs by the narrowly lanceolate leaf blade, purplish red pistil, slightly convex upper surface of stigma with a white triangular speckle and three inconspicuous Y-shaped wavy lines at center. Colour plates of the two similar species are provided for comparison.
Contribution of Deep Vertical Velocity to Deficiency of Sverdrup Transport in the Low-Latitude North Pacific
Authors: Zhang Kun , Wang Qiang , Yin Baoshu , Yang Dezhou , Yang Lina
Published: September 2023

Deep vertical velocity is a critical factor causing deficiencies in Sverdrup theory. However, few studies have focused on its influence in the low-latitude western Pacific. Through multiple analyses of observational, reanalysis, and simulation data, this study explored the contribution of deep nonzero vertical velocity to the Sverdrup transport inaccuracy in the low-latitude North Pacific. The vertical velocities inducing relatively small non-Sverdrup transport exist within 1500–2500 m, which exhibit similar patterns with opposite values to the south and north of 13°N. The zonally integrated meridional volume transport associated with these vertical velocities displays nonnegligible dipolar zonal bands west of approximately 150°W. The positive and negative transport bands, centered at 11° and 17°N, can reach an amplitude of approximately 8.0 Sv (1 Sv ≡ 106 m3 s−1) when integrated from the eastern boundary to 140°E. On average, such integrated meridional transport makes up roughly half of the prominent Sverdrup transport discrepancies in the central-western Pacific. Further investigation indicated that the spatial pattern of these vertical velocities is modulated by ocean topography and deep meridional currents. Moreover, a near-global test suggested that the meridional non-Sverdrup transport related to deep vertical velocity is widespread and undergoes remarkable multidecadal variation. This study reveals the disruptive role of deep vertical velocity in disturbing the Sverdrup balance and emphasizes the consideration of its long-term variation when diagnosing wind-driven circulation changes using Sverdrup theory.
Estimating the Volume Transport of Kuroshio Extension Based on Satellite Altimetry and Hydrographic Data
Authors: Guo Haihong , Chen Zhaohui , Yang Haiyuan , Long Yu , Zhu Ruichen , Zhang Yueqi , Jing Zhao , Yang Chen
Published: September 2023

In this study, an effective method of estimating the volume transport of the Kuroshio Extension (KE) is proposed using surface geostrophic flow inferred from satellite altimetry and vertical stratification derived from climatological temperature/salinity (T/S) profiles. Based on velocity measurements by a subsurface mooring array across the KE, we found that the vertical structure of horizontal flow in this region is dominated by the barotropic and first baroclinic normal modes, which is commendably described by the leading mode of empirical orthogonal functions (EOFs) of the observed velocity profiles as well. Further analysis demonstrates that the projection coefficient of moored velocity onto the superimposed vertical normal mode can be represented by the surface geostrophic velocity as derived from satellite altimetry. Given this relationship, we proposed a dynamical method to estimate the volume transport across the KE jet, which is well verified with both ocean reanalysis and repeated hydrographic data. This finding implicates that, in the regions where the currents render quasi-barotropic structure, it takes only satellite altimetry observation and climatological T/S to estimate the volume transport across any section.

Significance Statement

The Kuroshio Extension (KE) plays an important role in the midlatitude North Pacific climate system. To better understand the KE dynamic and its influences, it is very important to estimate the KE transport. However, direct observation is very difficult in this area. Combining a subsurface mooring array and climatological temperature/salinity data, the vertical structure of the KE is explored in this study using mode decomposition methods. The relationship between the vertical structure of the zonal velocity and surface geostrophic flow observed by satellite altimetry in the KE region is further investigated. Based on this relationship, the KE transport can be well estimated by using satellite altimetry observation and historical hydrographic observation.
Infusing Intersectional Pedagogy into Adult Education and Human Resource Development Graduate Education
Authors: Sim Eunbi , Bierema Laura L.
Published: September 2023

Intersectional pedagogy (IP) is an educational intervention to help learners develop a social justice consciousness about interlocking systems of oppression that create injustice at the individual, group, and societal levels. The purpose of the study is to explore tenets of IP and profile ways higher education instructors from adult education (AE) and human resource development (HRD) programs might infuse intersectional perspectives into their teaching. Based on a literature review, this work demonstrates the foundations, principles, strategies, and challenges of IP. Further, this article proposes a tailored course design model to help instructors enact IP in the classroom. This study will benefit AE and HRD scholars by increasing their understanding of IP. Further, it will contribute to developing adult learners’ capacity to examine workplaces and society in critical, intersectional ways and take more mindful, timely action to create more equitable organizations and communities.
Safety of an express freight train running over a bridge in crosswind
Authors: Wen Jingcheng , Li Qi , Lu Zhenggang
Published: September 2023

Owing to the blunt car body and high design speed of express freight trains, the running safety is significantly affected by crosswinds when the train runs over a bridge; moreover, severe accidents, such as derailment or overturning may occur. Therefore, adequate measures should be adopted to avoid the occurrence of such accidents. In this study, a finite element model of the train, ballastless track, and parameterized 5-span simply supported girder bridge along with modal superposition method are adopted to establish the train-track-bridge coupling dynamic system. Numerical simulation of stochastic wind speed, wind tunnel tests, and computational fluid dynamics (CFD) simulation of vehicle-bridge scale model were conducted to calculate the wind load acting on the train and bridge. The dynamic responses of the bridge and train were evaluated to present the diagrams of wind and train speed limits for safe operation. The results indicated that the running safety of the vehicle declined with the wind and train speeds, and the wheel unloading rate was the most sensitive to wind speed. For safe operation, the train speed must be restricted if the mean wind speed is greater than 22.7 m/s, and an extreme scenario of derailment may occur for a mean wind speed of 34.0 m/s. In addition, the wind speed limit should be appropriately adjusted and improved according to the pier height of the bridge and terrain category. This research provides a theoretical basis and data support for the assessment of safety of express freight trains in actual operation.
Exploring Big Data Usage to Predict Supply Chain Effectiveness: A Moderated and Mediated Model Linkage
Authors: Ali Amjad , Rafiq Asim , Hussien Muddassir , Sarwat Salman , Raziq Abdul
Published: September 2023

This study aims to predict the direct and indirect relationship between the usage of Big Data and the effectiveness of the Supply Chain (SC). Additionally, it identifies Top Management Support (TMS) as a moderator. The data were collected through the survey of small and medium-sized businesses (SMEs) and most respondents were senior and middle-level managers with in-depth knowledge of the SC and Big Data usage. SPSS and PLS 3.0 were used to test the hypothesis. The results demonstrate that Big Data usage impacts direct supply chain effectiveness (SCE), however, supply chain agility (SCA) and supply chain networks (SCNs) as mediators between SCE. TMS was used as a moderator between big data usage, SCA and SCNs. The research suggests that, among SMEs, this is the first study to be carried out in Pakistan that looked at the relationship between the usage of big data and the efficacy of SCs, with TMS acting as a moderator (SMEs).
Dubin Johnson Syndrome Masquerading as Biliary Atresia in a Neonate
Authors: Dhanawat Avantika , Bachina Prashant , Panda Santosh Kumar
Published: September 2023

Biliary atresia (BA), a surgical cause of neonatal cholestasis, needs timely intervention. A term male neonate presented with yellowish discoloration and pale stool on the third week of life, suspected as BA based on the liver function test and hepatobiliary iminodiacetic acid (HIDA) scan. His intraoperative cholangiogram was normal and finally diagnosed as a case of Dubin-Johnson syndrome (DJS) by whole exome sequencing. The baby became anicteric with the cholestasis regimen. DJS is one of the differential diagnoses of BA; genetic evaluation may be considered prior to an invasive cholangiogram in such cases.
Implantation of an arteriovenous graft through the peripheral vascular access in the presence of superior vena cava stenosis but a patent azygos vein: A case report
Authors: Wang Yan , Lei Xinyao , Song Xiaowei , Li Ling , Li Qiu
Published: September 2023

Long-term indwelling central venous catheters (CVCs) may cause complications, such as central venous disease (CVD). CVD eliminates the possibility of establishing new arteriovenous access. We herein describe a case in which an arteriovenous graft (AVG) is implanted through the peripheral veins and blood flows back to the patent azygos vein, secondary to superior vena cava stenosis. This shows that if the CVD is correctable or the collateral circulation is an alternative vascular pathway that allows blood to return back to the right atrium, the internal fistula flow is well-balanced with the collateral circulation and there are no clinical symptoms of CVD, an arteriovenous access can be established for the operation. This provides a viable, long-term vascular access option for hemodialysis patients with central venous resource depletion.
Citizens’ awareness of electoral campaign pledges
Authors: Duval Dominic , Pétry François
Published: September 2023

The theory of promissory representation (Mansbridge, 2003) proposes that voters select parties based on the pledges they made during the campaign. The elected parties then fulfill their promises and at the next election, voters reward or sanction the parties based on their pledge-fulfillment record. However, a fundamental assumption of promissory representation remains to be tested. If voters use party pledges to decide which party to vote for, they need to know which party made which pledges. To test the degree of awareness of citizens to party pledges (a factor we dub pledge awareness), we included a module in the 2019 Canadian Election Study (CES) that tasks citizens to associate correctly six pledges found in the different electoral platforms with their respective parties. We find that while citizens may not know all six pledges included in our study, nonetheless, the most frequently selected answers to our pledge awareness questions are the correct ones. We also find that party identification and the information resources at the disposal of citizens play a large role in the citizen’s capacity to succeed at this matching task. Our study indicates that respondents tend to be more aware of the pledges made by the party they identify with, and well-informed respondents are more aware of pledges made by the other parties.
Whiteness in our understanding of culture: A critical discourse analysis of the cultural responsivity practice frameworks in child protection
Authors: van Noppen Caitlin , Yassine Lobna , Olcoń Katarzyna
Published: September 2023

This article explores the conceptualization of cultural responsivity in Australian child protection through the critical Whiteness theory lens. Critical discourse analysis was deployed to examine the cultural responsivity concept in two statutory child protection documents from New South Wales (NSW), Australia. Interrogating the underlying assumptions present in the texts, the study demonstrated a narrow categorization of who is deemed ‘culturally diverse’ and a problematic conceptualization of cultural responsivity. We argue that these texts maintain Whiteness as the unexamined cultural norm and can reinforce the ‘Othering’ effect and racial disproportionality in the child protection system. We conclude with a call to practitioners to remain critical of the widely accepted concepts that inform their practice, such as cultural responsivity to avoid reinforcing racial inequality through their practice.
A review of Janus kinase/signal transducer and activator of transcription signaling and cytokines in the pain mechanism of rheumatoid arthritis
Authors: Xiong Yue , Song Xiaohui , Sheng Xiangrui , Wu Jian , Chang Xin , Ren Tian , Cao Jin , Cheng Tao , Wang Mingjun
Published: September 2023

Rheumatoid arthritis (RA) is a progressive autoimmune disease characterized by chronic synovitis and articular destruction. Pain is the earliest and most important symptom. The Janus kinase/stat signaling pathway not only participates in the physiological processes such as the growth and differentiation of normal cells, but also plays a significant role in the pathological mechanisms such as pain in RA patients. Pain in RA patients is mediated by both inflammatory and non-inflammatory factors, including central sensitization and peripheral sensitization. Cytokines can regulate the nociceptor threshold through the JAK pathway, which leads to sensitization. In this review, we provide an overview of the physiological basis of pain modulation, the underlying importance of cytokines and JAK/STAT pathway in pain modulation, and finally introduce the performance of JAK inhibitors in clinical research. Having a better understanding of the mechanism of pain in RA may provide new therapeutic ideas and directions for the clinical improvement of pain in RA patients.
Morin hydrate suppresses lipoteichoic acid-induced oxidative stress-mediated inflammatory events in macrophages via augmenting Nrf2/HO-1 and antioxidant defense molecules
Authors: Hsieh Cheng-Ying , Jayakumar Thanasekaran , Lin Kao-Chang , Yen Ting-Lin , Hsia Chih-Wei , Huang Wei-Chieh , Sheu Joen-Rong , Hsia Chih-Hsuan
Published: September 2023

Objectives

Oxidative stress induces chronic inflammatory diseases in aerobic organisms, and antioxidants from plants represent an efficient strategy to prevent this condition. Morin hydrate (MH), a bioactive flavonoid, has a wide range of pharmacological properties, including anti-inflammatory and anti-oxidant. This study evaluated the protective effects of MH on lipoteichoic acid (LTA)-induced inflammation in RAW 264.7 macrophages by testing the main oxidative and inflammatory biomarkers and also investigating the molecular pathways involved.

Methods

The antioxidant and anti-inflammatory effects of MH were evaluated in a cell-free system and RAW264.7 cells. Quantitative real-time PCR (RT-qPCR) and assay kits were used to measure the expression of nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1) mRNA, as well as the activity of antioxidant enzymes. The effects of MH on LTA-induced inducible nitric oxide synthase (iNOS), IL-1β, and TNF-α mRNA and protein expression were also evaluated by RT-qPCR and Western blotting.

Results

MH reduced DPPH and ABTS radicals in a cell-free system and LTA-induced ROS and NO production in RAW264.7 cells. MH upregulated Nrf2 and HO-1 mRNA expression and reversed LTA-mediated reduction of antioxidant enzymes, at a high concentration of 20 µM pretreated cells. MH also effectively attenuated LTA-induced iNOS, IL-1β, and TNF-α mRNA and protein expression, and these effects were reversed by ML385.

Conclusions

The study found that the Nrf2/HO-1 played role in the inhibition of LTA-induced oxidative stress in macrophages by MH. This study may consider to be a promising induced macrophage-targeted strategy via regulating anti-oxidative defense to control inflammatory-related disease.
Carotid total plaque area as an independent predictor of short-term subclinical polyvascular atherosclerosis progression and major adverse cardiac and cerebrovascular events
Authors: Genkel Vadim , Kuznetsova Alla , Lebedev Evgeniy , Salashenko Alexey , Savochkina Albina , Nikushkina Karina , Pykhova Lubov , Sumerkina Veronika , Shaposhnik Igor
Published: September 2023

Background:

The use of ultrasound-based methods for imaging of subclinical atherosclerosis, including measurement of carotid plaque burden (cPB), is a promising direction for further improvement of major adverse cardiac and cerebrovascular events (MACCE) prediction.

Objectives:

The aim of the study was to research the prognostic values’ significance of cPB indicators with regard to the short-term progression of polyvascular subclinical atherosclerosis and the long-term onset of MACCE.

Design:

Single-center prospective cohort study.

Methods:

The study included patients 40–64 years of age. All patients underwent duplex scanning (DS) of the carotid and lower limb arteries. The following cPB indicators were determined: carotid plaque score (cPS), maximum carotid plaque thickness (cPTmax), and carotid total plaque area (cTPA). The combined endpoint included the following components: cardiovascular death; nonfatal myocardial infarction; nonfatal stroke or transient ischemic attack (TIA); revascularization of the coronary and/or peripheral arteries.

Results:

The study included 387 patients, among whom 142 (36.7%) patients underwent repeated DS after 12–24 months. The median follow-up time was 20.0 (13.0; 36.5) months. MACCE were recorded in 33 (8.52%) of patients. cTPA and cPTmax, but not cPS, were independently associated with the progression of subclinical polyvascular atherosclerosis over a period of 13.9 months of follow-up. cTPA, but not cPTmax and cPS, was independently associated with the development of MACCE over a period of 20.0 months of follow-up. Only a cTPA > 42.0 mm2 proved to be an independent predictor of both the progression of subclinical polyvascular atherosclerosis and MACCE.

Conclusion:

In patients from 40 to 64 years of age with various cardiovascular risks, among the indicators of the cPB, only an increase in cTPA > 42.0 mm2 was shown to be independently associated with an increase in the relative risk (RR) of progression of subclinical polyvascular atherosclerosis by 2.38 (1.08–5.25) times, as well as with the development of MACCE by 3.10 (1.54–6.26) times.
Stroke Thrombectomy and Right Atrial Clot Aspiration in 29 Year Old Woman
Authors: Rao Rahul , Aladamat Nameer , Robbins Sarah , Jumaa Mouhammad , Zaidi Syed
Published: September 2023

We present a case report of a previously healthy 29 year old woman who developed thromboembolic events in rapid fashion after a recent orthopedic surgery. This case highlights the importance of understanding risk factors for clot formation even in those who had no prior events, the efficacy of novel aspiration techniques to remove emboli, and how rapid triaging of acute symptoms can lead to the best outcomes. She presented to the emergency department with shortness of breath and was found to have a large bilateral pulmonary embolus. She was given intravenous thrombolysis. Shortly after, she developed aphasia and right-sided weakness and was taken emergently for mechanical thrombectomy of a left middle cerebral artery occlusion. She was later found to have a patent foramen ovale and a highly mobile right atrial thrombus which was aspirated. Further evaluation revealed right lower extremity peroneal and popliteal deep venous thrombi. She was placed on anticoagulation, made a full clinical recovery, and was discharged home. Prompt recognition of symptoms, efficient in-hospital work flow, and a multidisciplinary approach led to an outstanding outcome in this young patient.
Attentional biases in PTSD, adjustment disorder, and prolonged grief disorder: Attentional interference as a potential transdiagnostic feature
Authors: Eberle David J. , Maercker Andreas
Published: September 2023

In the ICD-11, posttraumatic stress disorder (PTSD), adjustment disorder (AjD), and prolonged grief disorder (PGD) belong together to the new grouping of disorders specifically associated with stress, which are all characterized by intrusive core symptoms. As previous studies suggest that intrusive symptoms are associated with attentional biases, it is plausible that PTSD, AjD, and PGD are characterized by the same attentional biases as a transdiagnostic feature. The present study investigated 90 participants with symptoms of PTSD, AjD, or PGD. Individuals with a subclinical symptom presentation were also able to participate, resulting in an analogue sample with the group labels aPTSD, aAjD, and aPGD. All participants completed a symptom induction task to provoke symptoms related to attentional biases. Subsequently, a visual search task (VST) was implemented. This test assessed reaction times to trials that include stress-related, neutral, and generally negative stimuli. The VST featured an interference and facilitation condition to investigate different types of attentional biases. Findings showed that all groups were characterized by particularly fast reaction times to trials which included stress-related stimuli in the interference condition, which indicates a reversed attentional interference bias. This bias has not been reported before and is perhaps related to an avoidance behavior.
Breast cancer-associated paraneoplastic neuromyelitis optica with cervical cord compression and spondylosis requiring laminectomy: A case report
Authors: Srichawla Bahadar S , Sivakumar Shravan , Cheraghi Seyedeh N , Kipkorir Vincent , Garcia-Dominguez Maria A
Published: September 2023

Neuromyelitis optica, an autoimmune inflammatory disorder affecting the central nervous system, can occur in a paraneoplastic context, although rare. We report an intriguing case of a 71-year-old woman with a history of triple-negative infiltrating ductal breast carcinoma, manifesting with paraneoplastic neuromyelitis optica that led to significant respiratory failure and required a cervical laminectomy. The patient presented with pain in the left breast, weakness in the lower extremities, and neck pain. The neurological evaluation showed 2/5 muscle strength in all extremities, diffuse hyperreflexia, and loss of multimodal sensation below the shoulder. She developed acute respiratory failure that required mechanical ventilation. Magnetic resonance imaging highlighted a diffuse abnormal increase in T2 signal intensity throughout the posterior and central portion of the cervical and thoracic spinal cord consistent with longitudinally extensive transverse myelitis, and significant cervical cord compression at C3–C4. Magnetic resonance imaging of the brain showed non-enhancing T2/fluid-attenuated inversion recovery (FLAIR) white matter hyperintensities and cerebellar hemispheres. The serum cell-based assay study demonstrated a high anti-aquaporin-4 immunoglobulin G titer (>1:160) confirming the diagnosis of neuromyelitis optica. She was taken for bilateral laminectomy from C3 to C6. Despite intravenous methylprednisolone and plasmapheresis treatment, no significant recovery was achieved, necessitating tracheostomy and percutaneous endoscopic gastrostomy. Subsequent rituximab treatment led to a mild improvement, with no new lesions on repeat magnetic resonance imaging. This case raises suspicion of the potential for neuromyelitis optica to occur as a paraneoplastic phenomenon, strengthening the need for vigilance in patients with malignancies.
Perceived barriers to access to hepatitis C for people who inject drugs in Morocco: A qualitative explorative study
Authors: Belrhiti Zakaria , Serghini Fatima Zohra
Published: September 2023

Background

Worldwide, approximately there are 15.6 million people who inject drugs. Recently, a rising prevalence of hepatitis C virus among the people who inject drugs community (8.2 million, 40 to 80% of people who inject drugs) urged governments to implement targeted preventive and structural interventions. Yet, social stigma, poor interaction with health workers, and limited health literacy are critical challenges to equitable access to care. This study explores the perceived barriers and facilitators of people who inject drugs access to hepatitis C virus care in Morocco.

Methods

We adopted an explorative qualitative single-embedded case study design. We conducted 19 semi-structured interviews and a focus group discussion with people who inject drugs, health workers, and social community health workers. We performed an inductive qualitative data analysis using thematic analysis. We coded data using NVivo software. We summarized our findings using a causal loop diagram of critical barriers and facilitators.

Results

Multi-layered and interdependent factors constrain access to care for people who inject drugs. People who inject drugs are considered a vulnerable population experiencing irregular housing, lack of family support, gender-based stigmatization, and incarcerations. Individual factors include limited hepatitis C virus health literacy, mistrust in health workers, and poor interaction with health workers within healthcare facilities. Both individual and structural elements decrease their perceived self-worth and self-esteem and reinforce their perceived social stigmatization. This leads to a lack of motivation to engage in hepatitis C virus care delivery. We found that peer educators are perceived as trustworthy and credible sources of hepatitis C virus health-related knowledge.

Discussion

Poor access to hepatitis C virus treatment for people who inject drugs involved an intertwined set of individual factors (level of knowledge, perceived social stigma, reduced self-esteem, and self-worth) and structural factors such as poor interaction with health workers and mistrust in healthcare institutions. More attention needs to be paid to alleviate structural barriers by integrating peer education, multiagency collaboration, community engagement, and capacity building of health workers for equitable access of people who inject drugs to hepatitis C virus care.
Remote Didactic Education Effectively Increases Cardiac Critical Care Nursing Staff Knowledge in Low-Resource Settings
Authors: Kliot Tamara , Holloway Adrian , Spillman Katherine , Moss Julianne , Davis Natalie Louise , Ayalew Abebech , Bhutta Adnan , Ejigu Yayehyirad Mekonnen
Published: September 2023

Background: While progress has been made to decrease mortality in children under age five, there continues to be a need for improvement in the treatment of children with congenital heart disease. Many of these patients require surgical correction and live in areas without the expertise of surgical teams. Research has shown that appropriate training is critical to ensure the best clinical outcomes. The Ethiopian government has identified the need for increased training of health care professionals as a method to improve hospital outcomes. Methods: Twenty-five cardiac critical nurses participated in a remote didactic education curriculum over the course of multiple months. We used a pre- and post-test model to evaluate knowledge acquisition and retention after the curriculum. Nurses completed post-tests at 1-, 3-, 6-, and 12-month intervals to monitor knowledge retention over time. Results: We found a significant increase in nursing knowledge that was retained over the course of 12 months. Nursing knowledge on pre- and post-tests was impacted by experience level. However, after completion of the curriculum experience was not a significant factor. Conclusion: Virtual curriculum delivered via remote didactic education is an inexpensive and effective way to increase nursing knowledge in cardiac critical care. It encourages bidirectional learning and allows the sharing of expertise from individuals who may otherwise be limited by travel or finances. Our approach is generalizable and further research needs to be done to evaluate the effectiveness of this type of curriculum in other environments.