bluuebunny/crossref_metadata_2025 huggingface dataset:
Epidemiologic Disparities in Colon Cancer Screening and Adherence during the COVID-19 Pandemic: A Retrospective Cohort Analysis
Authors: Nwankwo Eugene Chiemeka , Hendrix Christian , Pollard Kelvin , Kallal Chad , Cruschiel Tim , III Frederick Buckhold , Hachem Christine Y
Published: January 2022

Background: Colorectal cancer (CRC) is the second-leading cause of death in the US. Despite the National Colorectal Roundtable goal of achieving 80% adherence, CRC screening remains underutilized, especially in the underinsured populations. Screening programs have been heavily disrupted during the COVID-19 pandemic.
Aim: This research was performed to explore the impact of the pandemic on the existing ethnic and gender disparities prevalent in CRC screening.
Methods: Patients were identified 1 year before and after COVID-19 precautions began, using March 1, 2020, as the inflection point. For each year, the primary inclusion criterion was an ordered colonoscopy. The outcome of interest was a colonoscopy performed. Differences by year and race were assessed using Chi-square analysis. A cohort of 1413 patients between age 45 and 75 for whom a colonoscopy was ordered was selected from EHR at a single large institution. 897 patients were in the pre-COVID group, and 516 were in the post-COVID group.
Results: There was a 51% reduction in screening colonoscopies performed. White patients had a decrease of 49%, and African Americans had a 55% reduction. Stool testing increased from 47% prior to the pandemic to 94% during the pandemic representing a greater than 100% increase in stool testing uptake.
Conclusion: The true impact of COVID-19 on colorectal cancer is yet to be uncovered as future

mortality estimates from CRC are ongoing. Due to the widespread closure of endoscopy centers and delay in screening, we believe that the pandemic worsened the screening disparities most prevalent among minority populations. Our retrospective analysis over the last two years points to the drastic reduction of screening for all races, and especially for African Americans. As life gradually returns to normal, it would be interesting to see how the past year has impacted the incidence and prevalence of CRC.
A Federated Graph Neural Network Framework for Privacy-Preserving Personalization
Authors: Huang Yongfeng , Wu Chuhan , Wu Fangzhao , Lyu Lingjuan , Qi Tao , Xie Xing
Published: January 2022

Graph neural network (GNN) is effective in modeling high-order interactions and has been widely used in various personalized applications such as recommendation. However, mainstream personalization methods rely on centralized GNN learning on global graphs, which have considerable privacy risks due to the privacy-sensitive nature of user data. Here, we present a federated GNN framework named FedGNN for both effective and privacy-preserving personalization. Through a privacy-preserving model update method, we can collaboratively train GNN models based on decentralized graphs inferred from local data. To further exploit graph information beyond local interactions, we introduce a privacy-preserving graph expansion protocol to incorporate high-order information under privacy protection. Experimental results on six datasets for personalization in different scenarios show that FedGNN achieves 4.0%~9.6% lower errors than the state-of-the-art federated personalization methods under good privacy protection. FedGNN provides a novel direction to mining decentralized graph data in a privacy-preserving manner for responsible and intelligent personalization.
Genome-wide Identification, Evolutionary and Functional Analyses of Kfb Family Members in Potato
Authors: Tang Ruimin , Dong Haitao , He Liheng , Li Peng , Shi Yuanrui , Yang Qing , Jia Xiaoyun , Li Xiu-Qing
Published: January 2022

Background: Kelch repeat F-box (KFB) proteins play vital roles in the regulation﻿ of multitudinous biochemical and physiological processes in plants, including growth and development, stress response and secondary metabolism. ﻿Multiple KFBs have been characterized in various plant species, but this family members have not been systematically identified and analyzed in potato. Results: Genome and transcriptome analyses of StKFB gene family were conducted to dissect the structure, evolution and function of the KFBs in Solanum tuberosum L. Totally, 44 StKFB members were identified and were classified into 5 groups according to their structural and phylogenetic features. The chromosomal localization analysis showed that the 44 StKFB genes were located on 12 chromosomes. Among these genes, two pairs of genes (StKFB15/16 and StKFB40/41) were predicted to be tandemly duplicated genes, and one pair of genes (StKFB15/29) was segmentally duplicated genes. The syntenic analysis showed that the KFBs in potato were closely related to the KFBs in tomato and pepper. Expression profiles of StKFBs in 13 different tissues and in potato plants with different treatments uncovered distinct spatial expression patterns of these genes and their potential roles in response to various stresses. Transcriptomic and qRT-PCR analyses of StKFBs ﻿deciphered that multiple StKFB genes were differentially expressed in three colored potato tubers. Genes that were highly expressed in yellow fleshed tubers (Jin-16) and were lowly expressed in the red- (Red Rose-2) or purple-fleshed (Xisen-8) tubers, such as StKFB07, StKFB15, StKFB23, StKFB29 and StKFB44, may negatively regulate anthocyanin biosynthesis.Conclusions: ﻿This study reports the structure, evolution and expression characteristics of the KFB family in potato. These findings set the stage for further study of functional mechanisms of StKFBs, and also provide candidate genes for potato genetic improvement.
A Monolithic Stochastic Computing Architecture for Energy and Area Efficient Arithmetic
Authors: Ravichandran Harikrishnan , Zheng Yikai , Schranghamer Thomas , Trainor Nicholas , Redwing Joan , Das Saptarshi
Published: January 2022

As the energy and hardware investments necessary for conventional high-precision digital computing continues to explode in the emerging era of artificial intelligence, deep learning, and Big-data [1-4], a change in paradigm that can trade precision for energy and resource efficiency is being sought for many computing applications. Stochastic computing (SC) is an attractive alternative since unlike digital computers, which require many logic gates and a high transistor volume to perform basic arithmetic operations such as addition, subtraction, multiplication, sorting etc., SC can implement the same using simple logic gates [5, 6]. While it is possible to accelerate SC using traditional silicon complementary metal oxide semiconductor (CMOS) [7, 8] technology, the need for extensive hardware investment to generate stochastic bits (s-bit), the fundamental computing primitive for SC, makes it less attractive. Memristor [9-11] and spin-based devices [12-15] offer natural randomness but depend on hybrid designs involving CMOS peripherals for accelerating SC, which increases area and energy burden. Here we overcome the limitations of existing and emerging technologies and experimentally demonstrate a standalone SC architecture embedded in memory based on two-dimensional (2D) memtransistors. Our monolithic and non-von Neumann SC architecture consumes a miniscule amount of energy < 1 nano Joules for s-bit generation and to perform arithmetic operations and occupy small hardware footprint highlighting the benefits of SC.
Exciton transport in molecular organic semiconductors boosted by transient quantum delocalization
Authors: Giannini Samuele , Peng Wei-Tao , Cupellini Lorenzo , Padula Daniele , Carof Antoine , Blumberger Jochen
Published: January 2022

Designing molecular materials with very large exciton diffusion lengths would remove some of the intrinsic limitations of present-day organic optoelectronic devices. Yet, the nature of excitons in these materials is still not sufficiently well understood. Here we present Frenkel exciton surface hopping, a highly efficient method to propagate excitons through truly nano-scale materials by solving the time-dependent Schrödinger equation coupled to nuclear motion. We find a clear correlation between diffusion constant and quantum delocalization of the exciton. In materials featuring some of the highest diffusion lengths to date, e.g. the non-fullerene acceptor Y6, the exciton propagates via a transient delocalization mechanism, reminiscent to what was recently proposed for charge transport. Yet, the extent of delocalization is rather modest, even in Y6, and found to be limited by the relatively large exciton reorganization energy. On this basis we chart out a path for rationally improving exciton transport in organic optoelectronic materials.
Evidence for late glacial oceanic carbon redistribution and discharge from the Pacific Southern Ocean
Authors: Iwasaki Shinya , Lembke-Jene Lester , Nagashima Kana , Arz Helge , Harada Naomi , Kimoto Katsunori , Lamy Frank
Published: January 2022

Southern Ocean deep-water circulation plays an important role in the global carbon cycle. On geological time-scales, upwelling along the Chilean continental margin likely contributed to the deglacial atmospheric carbon dioxide rise, but little quantitative evidence exists of carbon storage. Here, we use a new X-ray Micro-Computer-Tomography method to assess foraminiferal test dissolution as proxy for paleo-carbonate ion concentrations ([CO32−]). Our subantarctic Southeast Pacific sediment core depth transect shows significant deep-water [CO32−] variations during the Last Glacial Maximum and Deglaciation (10 – 22 ka BP). We provide evidence for an increase in [CO32−] during the early deglacial period (15-19 ka BP), followed by a ca. 40 µmol kg−1 reduction in Lower Circumpolar Deepwater (CDW). This decreased Pacific to Atlantic export of low-carbon CDW contributed to significantly lowered carbon storage within the Southern Ocean, highlighting the importance of a dynamic Pacific–Southern Ocean deep-water reconfiguration for shaping late-glacial oceanic carbon storage, and subsequent deglacial oceanic-atmospheric CO2 transfer.
Radiosynthesis and Evaluation of Cyclohexyl (5-(2-[11C-Carbonyl]acetamidobenzo[d]thiazol-6-yl)-2-Methylpyridin-3-yl)Carbamate ([11C]PK68) As a New Radioligand For Imaging Receptor-Interacting Protein 1 Kinase
Authors: Yamasaki Tomoteru , Kumata Katsushi , Hiraishi Atsuto , Zhang Yiding , Wakizaka Hidekatsu , Kurihara Yusuke , Nengaki Nobuki , Zhang Ming-Rong
Published: January 2022

Background: Receptor-interacting protein 1 kinase (RIPK1) is a key enzyme in the regulation of cellular necroptosis. Recently, cyclohexyl (5-(2-acetamidobenzo[d]thiazol-6-yl)-2-methylpyridin-3-yl)carbamate (PK68, 5) has been developed as a potent inhibitor of RIPK1. Herein, we radiosynthesized [11C]PK68 as a new positron emission tomography (PET) ligand for imaging RIPK1 and evaluated its potential in vivo.Results: We synthesized [11C]PK68 by reacting amine precursor 14 with [11C]acetyl chloride. At the end of synthesis, we obtained [11C]PK68 of 1200–1790 MBq (n = 10) with >99% radiochemical purity and a molar activity of 37–99 GBq/μmol starting from 18–33 GBq of [11C]CO2. The fully automated synthesis took 30 min from the end of irradiation. In a small-animal PET study, [11C]PK68 was rapidly distributed in the liver and kidneys of healthy mice after injection, and was subsequently cleared from their bodies via hepatobiliary excretion and the intestinal reuptake pathway. Although there was no obvious specific binding of RIPK1 in the PET study, [11C]PK68 demonstrated relatively high stability in vivo, and may be used as a lead compound for further candidate development.Conclusions: In the present study, we successfully radiosynthesized [11C]PK68 and evaluated its potential in vivo. We are planning to optimize the chemical structure of [11C]PK68 and conduct further PET studies on it using pathological models.
High-energy and long-life aluminum−sulfur battery: Employment of electrocatalytic function into continuous multiple reactions within quasi-solid-state electrolyte
Authors: Huang Zheng , Wang Wei , Song Wei-Li , Wang Mingyong , Chen Hao-Sen , Jiao Shuqiang , Fang Daining
Published: January 2022

Aluminum−sulfur (Al−S) batteries of ultrahigh energy-to-price ratios are promising for next-generation energy storage, while they suffer from large charge/discharge voltage hysteresis and short lifespan. Herein, an electrocatalyst-boosting quasi-solid-state Al−S battery is proposed, in which sulfur is anchored on the cobalt/nitrogen co-doped graphene (S@CoNG, as the positive electrode) and chloroaluminate-based ionic liquid (IL) is encapsulated into metal-organic frameworks (IL@MOF, as the quasi-solid-state electrolyte). Mechanistically, the Co−N bonds in CoNG act as electrocatalytic center to continuous induce breaking of Al−Cl bonds and S−S bonds and accelerate the kinetics of sulfur conversion, endowing the Al−S battery with much shortened voltage gap of 0.32 V and 0.98 V in the discharge voltage plateau. Within quasi-solid-state IL@MOF electrolytes, shuttle effect of polysulfides has been inhibited, which stabilizes the process of reversible sulfur conversion. Consequently, the assembled Al−S battery presents high specific capacity of 820 mAh g−1 and 78% capacity retention after 300 cycles. This concept here offers novel insights to design practical Al−S batteries for stable energy storage.
Implementation of Evidence-Based Patient Safety Practices: 4-Years’ Follow-up of a Nationwide Regulatory Intervention in Brazilian Hospitals
Authors: Costa Magda Machado de Miranda , Santana Heiko Thereza , de Carvalho André Anderson , Santos Ana Clara Ribeiro Bello dos , Ribeiro Cleide Felicia de Mesquita , Nogueira Maria Dolores Santos da Purificação , Gama Zenewton André da Silva
Published: January 2022

Background: Regulatory interventions are widely recommended to improve the quality of health services, but there are few studies on the possible models and their effects. The aim of this study is to describe the implementation process and analyse the results of a nationwide regulatory intervention for the implementation of patient safety practices.Methods: Four nationwide annual cross-sectional assessments were conducted in Brazilian hospitals with Intensive Care Unit beds. The participants involved all facilities operating during 2016-2019 (average N=1,989). The regulatory intervention theory aimed to increase adherence to safe evidence-based practices through national annual assessment involving a set of 21 validated structure and process indicators related to patient safety practices. At moment 1(Risk assessment), data were collected to classify hospitals according to the risk. In the sequence, the Sanitary Surveillance Centers (VISAS) carried out the analysis of the information sent by the hospitals. VISAS classified services into three groups according to compliance with the composite adherence indicator: High (67-100%); Medium (34-66%); and Low Compliance (0-33%). Moment 2 (Risk management) used responsive actions according to the hospital’s classification. Results: The intervention resulted in six annual cyclic stages and, between 2016-2019, 782 (40.1%), 980 (49.0%), 1,093 (54.3%) and 1,255 (61.8%) hospitals participated, respectively. 17 of the 20 indicators with at least two measurements had a significant improvement after national interventions (p<0.05). The overall percentage of compliance increased from 70.7 to 84.1 (p<0.001) and the percentage of hospitals with high compliance increased from 59.1 to 83.0 (p<0.001).Conclusion: The regulatory intervention used was a good tool to strengthen the information system and government actions to promote patient safety. The set of low-cost interventions seems to be useful to prioritise hospitals at higher risk and to induce responsive measures to implement patient safety practices in the evaluated context, promoting the efficiency of the regulatory process.
A Novel Mouse Model to Study Fracture Healing of Tibia
Authors: Leng Xiangyang , Wang Jianyu , Zhou Zhenwei , Jia Yuyan , Wei Yuchi , Han Jicheng , Gao Hongwei , Deng Wei , Wang Xukai , Wang Tiancheng , Zhang Jingcheng , Zhong Jinghong , Wu Hailong , Wei Longhao , Yao Baojin
Published: January 2022

Background Delayed union of most tibial fractures due to their special anatomical structures.So an effective animal model is very important to study the mechanism and method of fracture healing.However, due to the small tibia of mice, the operation is difficult, and the surgical model requires high surgical skills. The construction of the fixation model of intramedullary nail for this fracture has improved and simplified the traditional fixation model of intramedullary nail, which not only achieves the purpose of constructing the fracture model, but also makes it more simple and effective.Therefore, the aim of the current study was to develop a new mouse model to study fracture healing of tibia. Methods We chose a combination between an open osteotomy and intramedullary stabilization. The 22G needle was inserted into the fracture end in a closed manner by using an open approach for osteotomy at the middle and lower 1/3 level of the tibia.Fractured tibia were analyzed using microcomputed tomography and histology at days 7,14,21and 28after surgery. All animals displayed normal limb loading and a physio-logical gait pattern within the first three days after fracture. No animals were lost due to surgery or anesthesia. Results X-ray confirmed that the fracture types obtained by the fracture modeling method were transverse fractures. X-ray, Micro-CT, immunohistochemistry, histological staining and Real-time PCR showed that the fracture healing of mice was typical endochondral ossification, with high repeatability. Conclusion The mouse tibial fracture model established by intramedullary nailing is safe, rapid and simple. Its fracture healing is a typical intrachondral ossification with high repeatability, which can be better used for the study of molecular mechanism and clinical transformation of fracture healing and bone metabolism.
Correlation of Mismatch Repair Deficiency with Clinicopathological Features and Programmed Death-Ligand 1 Expression in Thyroid Carcinoma
Authors: Chen Xiao-Ping , Qiao Pei-pei , Tian Kai-Sai , Han Li-Tao , Ben Ma , Shen Cen-Kai , Zhao Run-Yu , Zhang Yi , Wei Wenjun
Published: January 2022

Background

Mutations in DNA mismatch repair (MMR) genes associated with thyroid carcinoma (TC) have rarely been reported, especially in East Asian populations.
Methods

We examined tumor tissue from a cohort of 241 patients diagnosed with TC between 2008 and 2020. MMR proteins were detected using tissue microarray-based immunohistochemistry in order to identify MMR-protein-deficient (MMR-D) and MMR-protein-intact (MMR-I) tumors. We retrospectively summarized the clinicopathologic characteristics of patients with MMR-D TC, measured the expression of PD-L1, and recorded overall survival (OS) and other clinical outcomes.
Results

In our cohort, there were 18 (7.5%) MMR-D (MLH1, MSH2, MSH6, and PMS2) patients, including 12 with papillary TC (PTC) (6.7%), 2 with poorly differentiated TC (PDTC) (4.7%), and 4 with anaplastic TC (ATC) (22.2%). Half of them (9/18) showed a specific deletion in MSH6, and 6 of them also carried variants in the MSH6 and PMS2 gene. Survival was significantly better in patients with MMR-D ATC than in those with MMR-I tumors (p=0.033). Four of the 18 MMR-D patients (22%) were found to be PD-L1 positive. Their OS was much shorter than that of PD-L1-negative patients.
Conclusions

MMR-D and PD-L1 positivity appear to be associated with clinicopathological characteristics and prognosis in TC. The results indicate that MMR status may have important prognostic significance in TC. Therefore, immune checkpoint inhibitors that target the PD-1/PD-L1 pathway may be a treatment option for TCs.
Seismic Evidence of Pop-up Tectonics Beneath the Shillong Plateau Area of Northeast India
Authors: Singh A. P. , Mishra O. P. , Singh O. P.
Published: January 2022

Our detailed analysis of high-quality arrival time data recorded by the local seismographic network using three-dimensional seismic tomography of the Shillong Plateau region using high-quality arrival times of the body wave phases recorded at a dense temporary seismic network. This technique is used to understand the heterogeneities of the crust and its implications for pop-up tectonics characterizing evaluation the of the Shillong Plateau. We investigated an area covering ~150 ×100 km2 that revealed seismicity to be confined in a depth range ≤ 60 km. High - velocity anomalies in the upper crust appear to be responsible for intense small to moderate seismic activity in the region. Crustal seismic velocities inferred from 3-D seismic tomography showed significant lateral heterogeneities beneath the lithosphere of the Shillong Plateau. High-velocity anomalies in the uppermost crust, interpreted as the Shillong Plateau act as a geometric asperity where interseismic strain may accumulate. Low-velocity anomalies in the lower crust probably play a major role to accommodating the stresses generated due to plate separation, culminating in future sources of great earthquakes. The geological faults are well imaged in the cross-sections and support the concept of Pop-up tectonics beneath the Shillong of NE India.
WITHDRAWN: An Evaluation of Optimal Friction Stir Welding Factors (FSWF) For Yellow Brass 405-20
Authors: Raza Syed Farhan , Khan Sarmad Ali , Habib Muhammad Salman , Ahmed Naveed , Ishfaq Kashif , Mehdi Ahmed
Published: January 2022

Friction stir welding (FSW) is a green, environmentally amicable, and solid-state joining technology. FSW can successfully weld a wide range of materials (similar/dissimilar parent materials) including aluminum, copper, steel, different alloys from these materials, plastics, composites. FSW of brass has already been accomplished by fewer researchers. In this research, yellow brass 405-20 is, therefore, welded with FSW that was never welded before. In this study, tool material utilized was M2 HSS that was also novel. Effect of two friction stir weld factors (FSWF), rotational speed (RS) and traverse speed (TS), was found on three output parameters i.e., weld temperature, weld strength and weld hardness. Weld temperature developed, was found to be 63.72% of melting point of base metal. A significant improvement in friction stir weld strength (FSWS) was also measured that was found to be 106.37% of the base brass strength. Finally, weld hardness was measured which was found to be 87.80% of original brass hardness. Based on main effects, optimal FSW factors were found to be 1450 rpm and 60 mm/min resulting interestingly in optimal temperature, optimal weld strength, and optimal hardness. Rotational speed (RS) was found to be significant to affect the weld temperature only at the friction stir weld zone (FSWZ) with the highest percent contribution (PCR) of 65.69%. However, PCR of transverse speed was found to be maximum for affecting weld strength as compared to its PCR towards both weld temperature and weld hardness. Current study was also deepened by microscopic investigation.
Comparative Analysis Over Tribology Characterization of TiAlN and TiAlSiN PVD Coating On Plasma Nitride Alloy 20
Authors: Sriniva R. Ganapathy , Palani S , Rajaravi C , Karthik S
Published: January 2022

The nickel-iron-chromium (alloy 20) is enriching by hybrid surface treatment through plasma nitride (PN) and physical vapor deposition (PVD) process. The plasma nitriding process takes 12 hours at 500°C. Potentiodynamic testing is used to characterize the corrosion performance of the treated material, followed by morphological analysis of the exposed surface; XRD, EDX, SEM, hardness, and tensile testing are used to investigate appropriate coating properties. Plasma nitride and hybrid PVD nickel-iron-chromium alloys exhibit perlite (γ + α ’) phases and martensite (γ + α) phases, respectively. The martensite microstructure ensures superior tensile strength and hardness. The pin-on-disc tribometer test proposes to analyze friction and hard-faced behavior in the dry sliding position. The inclusion of Si improves the adherent oxide film, resulting in a low wear rate in TiAlSiN alloy 20. Due to the presence of the passive film, TiAlSiN alloy 20 exposes the most passive region to attain better corrosion resistance.
Rapid Detection of Circulating Tumour DNA using Allele Specific Mini-Loop Mediated Isothermal Amplification
Authors: Allsopp Rebecca , Alexandrou Georgios , Toumazou Christofer , Ali Simak , Coombes Charles , Kalofonou Melpomeni , Shaw Jacqui
Published: January 2022

Isothermal amplification is an emerging approach for non-invasive, rapid and cost-effective real-time monitoring of cancer specific mutations through circulating tumour DNA (ctDNA). This study demonstrates a compact allele specific (AS) loop mediated isothermal amplification (LAMP) strategy, termed ‘AS-Mini-LAMP’, modelled using wild type (WT) and mutation specific reactions targeting the estrogen receptor ESR1 c.1138G>C (p.E380Q) missense mutation. Allele selectivity, encoded at the 5’-end of the forward and backward inner primers (FIP and BIP) promotes enhanced selectivity upon self-hybridisation, loop formation and self-primed exponential amplification. Inclusion of unmodified self-stabilising (USS) primers aimed to reduce the likelihood of non-specific allele amplification through competitive inhibition and to enhance reaction velocity through an assisted strand displacement ‘swarm’ priming effect. The two assays were optimised using short synthetic WT and E380Q mutant DNA templates, and subsequently validated to a limit of detection of 500 mutant copies in under 25 minutes in ddPCR-confirmed positive (20.7% variant allele frequency) and negative patient plasma cfDNA samples. These results demonstrate the ability of AS-Mini-LAMP to achieve sensitive and selective amplification of actionable mutations present within plasma ctDNA.
Investigation of the Relationship between MBP Gene Polymorphisms and Delayed Encephalopathy after Acute Carbon Monoxide Poisoning
Authors: Zhang Fan , Zeng Jiao , Zhang Xiaoli , Gu Jiapeng , Han Yongkai , Zhang Ping , Li Wenqiang , Gu Renjun
Published: January 2022

Background Increasing evidence reveals that delayed encephalopathy after acute carbon monoxide poisoning (DEACMP) results from the combined effects of environmental and genetic factors. The main pathological feature of DEACMP was generalized demyelination of cerebral white matter. Myelin basic protein (MBP) levels in cerebrospinal fluid (CSF) and serum samples from DEACMP patients were elevated.Objectives This study investigated the association of MBP single nucleotide polymorphisms(SNPs) (rs470555, rs470724, rs4890785, rs595997, rs76452994, and rs921336) with DEACMP. Methods We genotyped 416 DEACMP patients and 785 age, educational level, and sex-matched ACMP patients for rs470555, rs470724, rs4890785, rs595997, rs76452994, and rs921336 SNPs using the Agena MassArray. Results There were no significant differences in the allele frequency distribution, four genetic models, and genotype distributions between the DEACMP and ACMP groups for rs470555, rs470724, rs4890785, and rs595997. However, significant differences were observed for rs76452994 and rs921336.Conclusions This study revealed that the MBP polymorphisms, rs470555, rs470724, rs4890785, and rs595997, were not associated with DEACMP. Based on the codominant, dominant, and overdominant genetic inheritability patterns, the MBP rs76452994 and rs921366 polymorphisms were associated with DEACMP. Furthermore, the G allele of rs76452994 and T allele of rs921336 could lead to higher DEACMP risk.
Identification of a Pyroptosis-Related lncRNA Risk Model for Predicting Prognosis and Immune Response in Colon Adenocarcinoma
Authors: Tan Yuying , Lu Liqing , Liang Xujun , Chen Yongheng
Published: January 2022

Background: Colon adenocarcinoma (COAD) is one of the most common malignant tumors and diagnosed at an advanced stage with poor prognosis in the world. Pyroptosis is involved in the initiation and progression of tumors. This research focused on constructing a pyroptosis-related ceRNA network to generate a reliable risk model for risk prediction and immune infiltration analysis of COAD.Methods: Transcriptome data, miRNA-sequencing data and clinical information were downloaded from the TCGA database. Firstly, differentially expressed mRNAs (DEmRNAs), miRNAs (DEmiRNAs), and lncRNAs (DElncRNAs) were identified to construct a pyroptosis-related ceRNA network. Secondly, a pyroptosis-related lncRNA risk model was developed applying univariate Cox regression analysis and least absolute shrinkage and selection operator method (LASSO) regression analysis. The Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses were utilized to functionally annotate RNAs contained in the ceRNA network. In addition, Kaplan-Meier analysis, receiver operating characteristic (ROC) curves, univariate and multivariate Cox regression, and nomogram were applied to validate this risk model. Finally, the relationship of this risk model with immune cells and immune checkpoint blockade (ICB) related genes were analyzed.Results: Totally 5373 DEmRNAs, 1159 DElncRNAs and 355 DEmiRNAs were identified. A pyroptosis-related ceRNA regulatory network containing 132 lncRNAs, 7miRNAs and 5 mRNAs was constructed and a ceRNA-based pyroptosis-related risk model including 11 lncRNAs was built. Tumor tissues were classified into high- and low- risk groups according to the median risk score. Kaplan-Meier analysis showed that the high-risk group had a shorter survival time; ROC analysis, independent prognostic analysis and nomogram further indicated the risk model was a significant independent prognostic factor which had excellent ability to predict patients’ risk. Moreover, immune infiltration analysis indicated that the risk model was related to immune infiltration cells (i.e., B cells naïve, T cells follicular helper, Macrophages M1, etc.) and ICB-related genes (i.e., PD-1, CTLA4, HAVCR2, etc).Conclusions: This pyroptosis-related lncRNA risk model possessed good prognostic value and the ability to predict the outcome of ICB immunotherapy in COAD.
Reactions to problems in marriage
Authors: İNANÇ Betul BATTALOĞLU
Published: January 2022

Purpose: Violence within the family is a common problem that can be seen in almost most socio-economic groups, societies, all ages and all educational levels. This study was planned to investigate the behavior and attitudes and marital satisfaction levels of the spouses in the family life process.Methods: All citizens 18 years and older that are living in households in the Republic of Turkey have been included. Considering the existing population records, a stratified two-stage systematic cluster sampling method was applied. . Comparisons by the sex, educational level, and marital status satisfied were performed with the use of chi-square and multivariate regression analysis, correlation analysis. A p-value <0.05 was considered to be statistically significant.Result: Violent behaviors such as doing harm, breaking and hitting things were more intense in men. Aply physical violence was more common among males. Only maintaining silence, getting angry or sulking was statistically significant in women (p <0.000). Yelling, scolding, humiliating, separating the bedroom and decreasing spending money was statistically significant in males (p <0.000).Conclusion: All concepts related to marriage should be well defined because spouse satisfaction and conflicts can have different meanings. It suggests that raising awareness about domestic violence against women, knowing solution methods, informing about their rights and increasing social support may be beneficial in solving the problem.
Computer-aided Efficient Design and Performance Optimization of Cutting Head for Roadheader
Authors: Jin Xin , Zhao Guochao , Zhao Lijuan , Lin Guocong
Published: January 2022

The cutting head is the core working mechanism of the roadheader for coal-rock materials cutting. The efficient and high performance design of cutting head is the key to improve the road head digging and mining technology. In this paper, based on cutting head design theory and virtual prototype technology, we propose a computer-aided structure design and performance optimization method for cutting head. We compile the calculation code and realize the reading and storing of relevant data through Excel. In particular, to obtain more realistic cutting performance data of the cutting head, we construct a coupling model of cutting head cutting rock wall based on virtual prototype technology, and then establish a database matching structural parameters, working parameters, coal-rock properties and cutting performance through extensive simulations. Based on the method, we complete the design of EBZ220 roadheader cutting head. We show that our method can realize the fast and efficient design of cutting head, and the designed cutting head has good working performance.
Novel Multifunctional NIR-II Aggregation-Induced Emission Nanoparticles Assisted Intraoperative Identification and Elimination of Residual Tumor
Authors: Qu Qiaojun , Zhang Zeyu , Guo Xiaoyong , Yang Junying , Cao Caiguang , Li Changjian , Xu Pengfei , Hu Zhenhua , Tian Jie
Published: January 2022

Incomplete tumor resection is the direct cause of the tumor recurrence and metastasis after surgery. Intraoperative accurate detection and elimination of microscopic residual cancer improve surgery outcomes. In this study, a powerful D1-π-A-D2-R type phototheranostic based on aggregation-induced emission (AIE)-active the second near-infrared window (NIR-II) fluorophore is designed and constructed. The prepared theranostic agent, A1 nanoparticles (NPs), simultaneously shows high absolute quantum yield (1.23%), excellent photothermal conversion efficiency (55.3%), high molar absorption coefficient and moderate singlet oxygen generation performance. In vivo experiments indicate that NIR-II fluorescence imaging of A1 NPs precisely detect microscopic residual tumor (2 mm in diameter) in the tumor bed and metastatic lymph nodes. More notably, a novel integrated strategy that achieves complete tumor eradication (no local recurrence and metastasis after surgery) is proposed. In summary, A1 NPs possess superior imaging and treatment performance, and can detect and eliminate residual tumor lesions intraoperatively. This work provides a promising technique for future clinical applications achieving improved surgical outcomes.
Guideline Adherence and Implementation of Tumor Board Therapy Recommendations for Patients With Gastrointestinal Cancer
Authors: Krause Alina , Stocker Gertraud , Gockel Ines , Seehofer Daniel , Hoffmann Albrecht , Bläker Hendrik , Dennecke Timm , Kluge Regine , Lordick Florian , Knoedler Maren
Published: January 2022

Purpose: Although participation in multidisciplinary tumor boards (MTBs) is an obligatory quality criterion for certification, there is scarce evidence, whether MTB recommendations are consistent with consensus guidelines and whether they are followed in clinical practice. Reasons of guideline and tumor board deviations are poorly understood so far. Methods: MTBs recommendations from the weekly MTB for gastrointestinal cancers at the University Cancer Center Leipzig/Germany (UCCL) in 2020 were analyzed for their adherence to therapy recommendations as stated in National German guidelines and implementation within an observation period of 3 months. To assess adherence, an objective classification system was developed assigning a degree of guideline and tumor board adherence to each MTB case. For cases with deviations, underlying causes and influencing factors were investigated and categorized. Results: 76% of MTBs were fully adherent to guidelines, with 16% showing deviations, mainly due to study inclusions and patient comorbidities. Guideline adherence in 8% of case discussions could not be determined, especially because there was no underlying guideline recommendation for the specific topic. Full implementation of the MTBs treatment recommendation occurred in 64% of all cases, while 21% showed deviations with primarily reasons of comorbidities and differing patient wishes. Significantly lower guideline and tumor board adherences were demonstrated in patients with reduced performance status (ECOG-PS ≥ 2) and for palliative intended therapy (p=.002/.007). Conclusion: The assessment of guideline deviations and adherence to MTB decisions by a systematic and objective quality assessment tool could become a meaningful quality criterion for cancer centers in Germany.
Detection Of Surface Defects And Subsurface Defects Of Polished Optics With Multisensor Image Fusion
Authors: Sun Huanyu , Wang Shiling , Hu Xiaobo , Liu Hongjie , Zhou Xiaoyan , Huang Jin , Cheng Xinglei , Sun Feng , Liu Yubo , Liu Dong
Published: January 2022

Surface defects (SDs) and subsurface defects (SSDs) are the key factors decreasing the laser damage threshold of optics. Due to the spatially stacked structure, accurately detecting and distinguishing them has become a major challenge. Herein a detection method for SDs and SSDs with multisensor image fusion is proposed. The optics is illuminated by a laser under dark field condition, and the defects are excited to generate scattering and fluorescence lights, which are received by two image sensors in a wide-field microscope. With the modified algorithms of image registration and feature-level fusion, different types of defects are identified and extracted from the scattering and fluorescence images. Experiments show that two imaging modes can be realized simultaneously by multisensor image fusion, and HF etching verifies that SDs and SSDs of polished optics can be accurately distinguished. This method provides a more targeted reference for the evaluation and control of the defects of optics, and exhibits potential in the application of material surface research.
A New Approach to Mixed/Boundary Friction Prediction Using the Logistics Curve
Authors: Taylor Robert Ian , Sherrington Ian
Published: January 2022

There is a strong focus on improving the energy efficiency of machines. Over the last 20-30 years, one way to improve energy efficiency has been to reduce lubricant viscosity. This also has the effect of leading to thinner oil films between the machine’s moving surfaces and is likely to lead to increased mixed/boundary friction. Accurately predicting friction in the mixed/boundary friction regime is therefore becoming of great importance. The work reported here suggests that commonly used asperity friction models significantly underestimate friction in the mixed/boundary friction, and a new model, based on a logistic curve fit, gives a better estimate of mixed/boundary friction, provides good agreement with experimental friction data (from Mini Traction Machine experiments), and is much more straightforward for engineers and tribologists to apply for the estimation of mixed/boundary friction losses.
Auxora Vs. Placebo for the Treatment of Patients with Severe COVID-19 Pneumonia: A Randomized Clinical Trial
Authors: Bruen Charles , Al-Saadi Mukhtar , Michelson Edward , Tanios Maged , Mendoza-Ayala Raul , Miller Joseph , Zhang Jeffrey , Stauderman Kenneth , Hebbar Sudarshan , Hou Peter
Published: January 2022

Background: Calcium release-activated calcium (CRAC) channel inhibitors block proinflammatory cytokine release, preserve endothelial integrity and may effectively treat patients with severe COVID-19 pneumonia. Methods: CARDEA was a phase 2, randomized, double-blind, placebo-controlled trial evaluating the addition of Auxora, a CRAC channel inhibitor, to corticosteroids and standard of care in adults with severe COVID-19 pneumonia. The primary endpoint was time to recovery through Day 60, with secondary endpoints of all-cause mortality at Day 60 and Day 30. Due to declining rates of COVID-19 hospitalizations and encroachment of prohibited medications as standard of care, the trial was stopped early. Results: The pre-specified efficacy set consisted of the 261 patients with a baseline imputed PaO2/FiO2 £200 with 130 and 131 in the Auxora and placebo groups, respectively. Time to recovery was 7 vs. 10 days (P=0.0979) for patients who received Auxora vs. placebo, respectively. The all-cause mortality rate at Day 60 was 13.8% with Auxora vs. 20.6% with placebo (P=0.1449); Day 30 all-cause mortality was 7.7% and 17.6%, respectively (P=0.0165). Similar trends were noted in patients on high flow nasal cannula at baseline or those with a baseline imputed PaO2/FiO2 ≤100. Serious adverse events occurred less frequently in patients treated with Auxora vs. placebo. Conclusions: Auxora was safe and well tolerated with strong signals in both time to recovery and all-cause mortality through Day 60 in patients with severe COVID-19 pneumonia. Further studies of Auxora in combination with corticosteroids and other immunomodulatory agents are warranted.Trial registration: NCT04345614
SARS-CoV-2 Omicron Outbreak in a Dormitory in Saint-Petersburg, Russia
Authors: Bazykin Georgii A. , Danilenko Daria M. , Komissarov Andrey B. , Yolshin Nikita , Shneider Olga V. , Nabieva Elena , Klink Galya V. , Shvyrev Nikita , Konovalova Nadezhda , Zheltukhina Alyona , Fadeev Artem , Komissarova Kseniya , Ksenafontov Andrey , Musaeva Tamila , Eder Veronica , Shchur Vladimir , Lioznov Dmitry
Published: January 2022

The B.1.1.529 Omicron variant of SARS-CoV-2 is rapidly spreading, displacing the globally prevalent Delta variant. Before December 16, 2021, community transmission had already been observed in tens of countries globally. However, in Russia, all reported cases had been sporadic and associated with travel. Here, we report an Omicron outbreak at a students’ dormitory in Saint Petersburg, Russia. Out of the 462 sampled residents of the dormitory, 206 (44.6%) tested PCR positive, and 159 (77.1%) of these infections carried the S:ins214EPE insertion, indicating that they were of the Omicron strain. 104 (65%) of Omicron-positive patients have been vaccinated and/or reported previous covid-19. Whole genome sequencing confirmed that the outbreak is caused by the Omicron variant. Phylogenetic analysis showed that the outbreak has a single origin, and belongs to the S:346K sublineage of Omicron which may be characterized by an increased rate of spread, compared to other Omicron sublineages. The rapid spread of Omicron in a population with preexisting immunity to previous variants underlines its propensity for immune evasion.
Simulating Regional Cassava Yield Gap in Nigeria
Authors: Srivast Amit Kumar , Gaiser Thomas , Akinwumiju Akinola Shola , Zeng Wenzhi , Ceglar Andrej , Ezui Kodjovi Senam , Ewert Frank , Adelodun Adedeji , Adebayo Abass , Sobamowo Jumoke , Singh Manmeet , Rahimi Jaber
Published: January 2022

Cassava production is essential for food security in Sub-Saharan Africa and serves as a major calorie- intake source in Nigeria. Here we use a crop model, LINTUL5, embedded into a modeling framework SIMPLACE to estimate potential cassava yield gaps (Yg) in 30 states of Nigeria. Our study of climate parameter influence on the variability of current and potential yields and Yg shows that cumulative radiation and precipitation were the most significant factors associated with cassava yield variability (p = 0.01). The cumulative Yg mean was estimated as 18202 kg∙ha-1, with a maximum of 31207 kg ha-1 in Kano state. Across the states, nutrient limitation accounts for 55.3% of the total cassava yield gap, while the remaining 44.7% is attributed to water limitation. The highest untapped water-limited yields were estimated in States, such as Bauchi, Gombe, and Sokoto, characterized by the short rainy season. Conclusively, the current cassava yield levels can be increased by a factor of five through soil fertility enhancement and with irrigation, particularly in semi-arid regions.
Herbs’ Disease-matched Pharmacological Mechanisms of HuanglianJiedu Decoction in Behavioral and Psychological Symptoms of Dementia in Alzheimer's Disease
Authors: Ma Su-Ya , Wang Xu , Shi Jing
Published: January 2022

Along with cognitive deficit, behavioral and psychological symptoms in dementia (BPSD) is another characteration of Alzheimer's disease that hamper clinical management and exacerbate burden for caregivers. However, therapeutic management of BPSD remains challenging. HuanglianJiedu decoction (HLJDD), a traditional Chinese prescription which contains Coptidis rhizome(Huang lian), Scutellariae radix (Huang-qin), Phellodendri chinrnsis cortex (Huang-bai) and Gardeniae fructus (Zhi-zi), is applied to treat BPSD. So elucidating the herbs’ disease-matched pharmacological mechanisms underlying HLJDD, further put forward each herbs’ disease-matched combination are critical to the application of HLJDD. In this study, network pharmacology was used to determine the targets and biological processes regulated by HLJDD in the treatment of BPSD. Moreover, molecular docking was utilized to evaluate the binding activity between the herbs' main active ingredients and neurotransmitter receptors. The results showed that the KEGG signaling pathway of HLJDD in treating BPSD mainly lies in TNF signaling pathway and AGE-RAGE signaling pathway in diabetic complications. Scutellariae radix and Phellodendri chinrnsis cortex exhibited better anti-BPSD effects when compared to Coptidis rhizoma and Gardeniae fructus. Scutellariae radix exhibited superior anti-neuroinflammation functions, with better blood vessel regulation effects. Phellodendri chinrnsis cortex showed a higher binding affinity to the dopamine D2 receptor (DRD2) and 5-hydroxytryptamine receptor 2A (HTR2A). Coptidis rhizoma and Gardeniae fructus were better in neuronal signaling. In conclusion, for treating BPSD, Scutellariae radix and Phellodendri chinrnsis cortex are the principal herbs while Coptidis rhizoma and Gardeniae fructus are the ancillary herbs. Beta-sitosterol, stigmasterol, chelerythrine, campesterol and berberine are the potential effective ingredients in treating BPSD.
Influencing Factors Associated with Delayed Initiation of Insulin Among Patients with Type 2 Diabetes Mellitus at The Diabetes Clinic of a Tertiary Hospital in Ethiopia
Authors: Reshid Elham , Habte Bruck Messele , Kebede Tedla , Fenta Teferi Gedif
Published: January 2022

Background

Guidelines recommend the initiation of insulin in patients with type 2 diabetes mellitus who failed on maximum dose of oral medications. However, time to initiation is inconsistent due to different barriers resulting in delay and thus leads to failure to achieve glycemic control which in turn may lead to different complications. The aim of this study was to explore factors influencing the delayed initiation of insulin among patients with type 2 diabetes being managed at the Diabetes Clinic of Tikur Anbessa Specialized Hospital.
Methods

A qualitative descriptive study design was employed. Data was collected using in-depth interviews with 27 participants, including patients and healthcare providers. Audio-recorded data was transcribed and then thematically analyzed.
Results

Different factors influencing the delayed initiation of insulin in patients with type 2 diabetes mellitus were revealed. Patient factors included beliefs about the necessity of insulin and concerns related to starting insulin. Physician factors included perceived patient’s situation and lack of clinical competency. Health institution factors included inadequate laboratory set up and absence of contextual guidelines for diabetes management including insulin initiation.
Conclusions

The study findings indicated different influencing factors some of which were similar to those reported from other settings while there were others which somehow were unique to study setting. These are indicative of the need to implement interventions such as strengthening the patients’ diabetes health education program that is considerate of the religious, cultural, and social aspects of the society.