bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation between lipid profile and cognitive function deterioration in ischemic stroke patients
Authors: Mirawati Diah Kurnia , Budianto Pepi , Prabaningtyas Hanindia R. , Subandi Subandi , Danuaji Rivan , Ristinawati Ira , Tedjo Raden A.A. , Zakiah Indana Z. , Putra Stefanus E. , Hafizhan Muhammad
Published: December 2024

Context: The second most common type of dementia is vascular dementia, caused by cerebrovascular disease. The decline in cognitive function after ischemic stroke occurs with varying degrees of severity and onset. This variability is attributed to the overlapping neurodegenerative and vascular damage.

Aims: To investigate the correlation between lipid profile, a biomarker of vascular dysfunction, and cognitive function in ischemic stroke patients.

Methods: A total of 52 respondents (mean age 64.21 ± 9.78 years) were recruited, and the Spearman correlation test found a moderate positive correlation (r=0.658, p=0.04) between lipid profile and cognitive function deterioration. The ordinal regression analysis was used to calculate the odds ratio (OR).

Results: The results showed that the OR for cognitive function deterioration associated with high-density lipoprotein (HDL), low-density lipoprotein (LDL), triglycerides, and total cholesterol were -1.54 (95% CI -0.98 - -3.46, p=0.002), 1.78 (95% CI 1.27-2.46, p=0.000), 2.48 (95% CI 1.39-4.92, p=0.04), and 1.54 (95% CI 1.04-2.48, p=0.003) respectively.

Conclusion: Based on the results, a positive correlation with moderate strength was observed between lipid profile and cognitive function deterioration in ischemic stroke patients.
Effect of erythropoietin on cerebral palsy prevention in hypoxic-ischemic encephalopathy. Hemoglobin, C-reactive protein, caspase-3, and tumor necrosing factor-α levels
Authors: Nur Fadhilah Tia , Salimo Harsono , Pusponegoro Hardiono D. , Probandari Ari Natalia , Purwanto Bambang , Soetrisno Soetrisno
Published: December 2024

Context: Hypoxic ischemic encephalopathy (HIE) is one of the leading causes of cerebral palsy (CP) and neonatal mortality in developing countries. Erythropoietin (Epo) is one of the newest neuroprotective therapies to prevent cerebral palsy.

Aims: To analyze the effect of Epo as a neuroprotective agent to prevent CP.

Methods: A randomized, double-blind, placebo-controlled trial was conducted between January and October 2022 in the neonatology ward at a tertiary hospital in Surakarta, Indonesia. Twenty-five infants born at 32 weeks or more of gestation with HIE based on Thompson’s criteria were determined to receive Epo or placebo treatments. After their birth, as well as at 2, 3, 4, and 5 days of age, saline placebo or Epo (1000 IU per kilogram of body weight) was administered intravenously within 24 hours. Hemoglobin, c-reactive protein (CRP), caspase-3, and tumor necrosing factor-' (TNF-α) levels were measured both pre- and post-treatment. Neurological examination was performed at 2, 4, and 6 months of age to assess the occurrence of CP.

Results: Hemoglobin and caspase-3 levels displayed an effect of Epo administration, in contrast with no significant difference found on CRP and TNF-a levels after the same treatment. However, the differences in the occurrence of cerebral palsy in the treatment group were statistically insignificant.

Conclusion: Epo has significant neuroprotective effects on caspase-3 levels, but this is not enough to prevent CP.
Zinc supplementation in reducing myeloperoxidase level in chronic suppurative otitis media without cholesteatoma
Authors: Sudrajad Hadi , Pratiwi Dewi , Primadewi Novi , Nurhidayah Nurhidayah
Published: December 2024

Context: The pathogenesis of chronic suppurative otitis media (CSOM) remains unclear, but it has been reported that myeloperoxidase (MPO) contributes significantly to chronic CSOM processes. Given the role of MPO in CSOM pathogenesis, antioxidant therapy such as zinc is believed to be an adjunctive therapy to the existing standard therapy for optimal treatment.

Aims: To analyze the effect of zinc on MPO in patients with CSOM without cholesteatoma.

Methods: This research was conducted at the ENT Clinic of Dr. Moewardi Hospital, Indonesia, using a pretest-post-test control group design. Samples in the investigation were divided into two treatment groups: zinc supplementation and placebo for 30 days. Furthermore, to determine the effectiveness of zinc supplementation, MPO serum levels were measured using an MPO ELISA kit.

Results: The mean level of MPO decreased significantly from 3.17 ± 1.47 ng/mL to 0.65 ± 0.48 ng/mL (p=0.001) after intervention with zinc supplementation, meanwhile after the intervention with placebo, the mean level of MPO also lowered insignificantly from 3.08 ± 1.05 ng/mL to 2.45 ± 0.78 ng/mL (p=0.082). A significant difference was also found in MPO level changes within the zinc group compared to the placebo group (0.63 ± 1.13 ng/mL vs. 2.51 ± 1.24 ng/mL) (p=0.001).

Conclusion: Zinc has a modulator effect in the inflammation cascade, which can decrease MPO levels in CSOM without cholesteatoma. This opens the possibility of using zinc supplementation as an additional therapy to the existing standard of CSOM therapy.
Effect of chitosan nanoparticles from red snapper scales (Lutjanus sp.) on pulp repair: In vivo study
Authors: Widyastuti Noor Hafida , Prayitno Adi , Cilmiaty Risya , Wasita Brian
Published: December 2024

Context: Iatrogenic actions leading to exposed pulp can result in pulp inflammation, with Reversible Pulpitis being a common condition among the general population. Pulp capping treatments are essential for supporting pulp repair and promoting the formation of reparative dentin. The choice of pulp capping material plays a crucial role in the success of this treatment.

Aims: To assess the impact of chitosan nanoparticles (CN) derived from red snapper scales (Lutjanus sp.) on pulp repair, as indicated by the expression of TGF-β1 and the formation of reparative dentin.

Methods: The research began with the preparation of CN extracted from red snapper fish scales using the ionic gelation method. Subsequently, an experimental animal model of reversible pulpitis was established. The study was conducted in vivo using 18 Sprague Dawley rats. Three groups were included: reversible pulpitis, reversible pulpitis with Ca(OH)2 application, and reversible pulpitis with CN application. Observations were made regarding the expression of TGF-β using ELISA and the formation of reparative dentin through histopathological examination.

Results: The results indicated a significant difference between groups, with a one-way ANOVA Test yielding a p-value of 0.049 for TGF-β1 expression and a Kruskal-Wallis test yielding a p-value of 0.009 for dentin reparative formation.

Conclusion: Chitosan nanoparticles derived from red snapper scales have demonstrated the ability to enhance pulp repair by elevating TGF-β expression and promoting the formation of reparative dentin.
In silico study of α-synuclein pathology in Parkinson's disease and the potential of H2O2 as complementary therapy
Authors: Layla Athiyah , Widyarti Sri , Sumitro Sutiman Bambang
Published: December 2024

Context: Parkinson´s disease (PD) is caused by protein aggregates composed of α-synuclein (αSyn) and its pathologies, such as mitochondrial dysfunction, loss of dopamine neurons, dysregulation of the dopamine transporter (DAT), and absorption of αSyn. Treatment with L-DOPA could not overcome it. Therefore, it requires complementary therapy with H2O2 low dose.
Aims: To evaluate the potential of H2O2 as a complementary therapy with L-DOPA.
Methods: The three-dimensional (3D) ligand and protein target structures were retrieved from PubChem and Protein Data Bank (PDB). H2O2, as ligand, was converted using the Open Babel, which integrated with PyRx v.0.9.8. The molecular docking program used AutoDock Vina as a plug-in in PyRx v.0.9.8. Docking visualization results were analyzed using PyMOL v.2.5.5 (Schrodinger, LLC) and Discovery Studio 2021 Client v21.1.0.20298. The protein-protein docking program used an HDOCK server (Lab of Biophysics and Molecular Modeling, Huazhong University). Molecular dynamics simulation used YASARA Structure v.23.9.29.
Results: H2O2 could prevent the formation of αSyn fibrils by reducing the binding affinity between αSyn proteins. H2O2 could avoid mitochondrial dysfunction and loss of dopamine neurons by preventing αSyn binding to VDAC. Dysregulation of the DAT could be avoided by the ability of H2O2 to prevent αSyn binding DAT and avoid αSyn uptake by preventing αSyn binding to LRP1.
Conclusions: The H2O2 low dose has the potential to be a complementary therapy with L-DOPA.
Impact of Ocean Acidification on Marker Enzymes in Asian Seabass Lates Calcarifer (Bloch)
Authors: S Karthikeyan , P Sureshkumar , C Dinakaran , A Chezhian , Soundarapandian P.
Published: December 2024

Backgrounds: The influence of ocean acidification (OA) is particularly significant on calcifying organisms in marine environment. A possible explanation for acidification-induced changes in fish behaviour is that acidification interferes with marker enzymes in the liver, muscle and brain. Under a range of severe environmental circumstances, marine organisms can be susceptible to oxidative stress and results in the changes in the biochemical components which can be assessed to know the health status of organisms.
Aim of the Works: The aim of this study is to observe the impact of ocean acidification in Asian seabass Lates calcarifer and to employ a large number of biomarker to discover distinct and unique patterns. For this the fingerlings of L. calcarifer were exposed to OA, in order to understand the changes in marker enzymes in liver, muscle and brain of L. calcarifer.
Methodology: Fish fingerlings were exposed to OA condition with two different pH (7.8 and 7.5) for a period of 9 weeks in order to assess changes in biomarker. Acid phosphatase (ACP) and alkaline phosphatase (ALP), alanine transaminase (ALT), and aspartate transaminase activity (AST) were examined in the liver, brain and muscles of fish.
Results: The Liver has considerably higher in ACP and ALP enzymes after 3 weeks of OA exposure. AST and ALT marker enzymes were induced in the brain at greater levels and in most cases, the entire marker enzymes in the liver, muscle and brain were concentration dependent and also the exposure period. The observed changes in marker enzymes which detected in the brain and liver tissues of L. calcarifer were statistically significant.
Conclusions: The present study showed a significant association between the entire biomarkers tested in fish exposed to OA. Overall, the results indicate that brain and liver is the most vulnerable component to OA exposure when compared to muscles and brain it may be employed as a bioindicator of OA exposure.
IMPLEMENTASI KURIKULUM MERDEKA SEKOLAH DASAR DI KOTA BIMA
Authors: Jumiati Anti , Anisah Anisah , Lastuti Sri
Published: December 2024

Evaluasi kurikulum merdeka bertujuan untuk mengetahui sejauh mana kurikulum tersebut diimplementasikan dengan baik dan untuk mengidentifikasi bagaimana implementasi Kurikulum Merdeka di sekolah, praktik pembelajaran dan faktor-faktor pendukung, serta hambatan dan tantangan yang dihadapi. Penelitian ini menggunakan model evaluasi penerapan CIPP (Context, Input, Process, Product). Metode pengumpulan data dilakukan melalui wawancara, observasi, dan dokumentasi, dengan pendekatan mixed method. Subjek wawancara terdiri dari kepala program, guru senior, dan siswa. Kepala program dipilih karena memiliki wawasan strategis mengenai perencanaan dan tujuan program. Data hasil wawancara dianalisis secara deskriptif kualitatif, sedangkan data observasi dianalisis secara deskriptif kuantitatif. Hasil penelitian menunjukkan bahwa implementasi Kurikulum Merdeka secara umum sudah tergolong baik pada semua aspek CIPP, namun masih perlu ditingkatkan untuk mencapai kriteria sangat baik. Praktik implementasi kurikulum juga sudah cukup memuaskan, didukung oleh keantusiasan guru dan kepala sekolah dalam membangun komunitas belajar dan mengembangkan inovasi. Faktor-faktor pendukung, seperti kesiapan tenaga pendidik dan sarana prasarana, juga berperan penting dalam keberhasilan implementasi. Hambatan penelitian yaitu terbatasannya buku ajar, kurangnya kompetensi guru dalam evaluasi penilaian, serta kendala yang dihadapi peserta didik. Simpulan, implementasi Kurikulum Merdeka di SD se-Kota Bima tergolong baik, namun perlu peningkatan lebih lanjut terutama dalam aspek penilaian dan penyediaan sumber belajar agar hasilnya lebih optimal.
PENGEMBANGAN BAHAN AJAR MULTIMEDIA INTERAKTIF SISPERMA DENGAN PENDEKATAN DIFERENSIASI UNTUK MENINGKATKAN MINAT BELAJAR IPAS SISWA KELAS 5 SD
Authors: Thohir M. Anas , Jatayu Putri Dataliya , Wilujeng Rahma Islamiati , Nadia Rifdah , Hidayah Rizqi Nurul , Miranti Sinta Dwi , Rahma Selin Dita
Published: December 2024

Penelitian ini bertujuan untuk mengembangkan sebuah bahan ajar multimedia interaktif dengan pendekatan diferensiasi guna meningkatkan minat belajar siswa kelas 5 pada mata pelajaran Ilmu Pengembangan Alam dan Sosial (IPAS) materi Sistem Pernapasan Manusia. Metode penelitian yang digunakan adalah Research and Development (R&D), dengan model pengembangan ADDIE yang mempertimbangkan gaya belajar siswa yang beragam. Bahan ajar SISPERMA ini dikembangkan sesuai dengan kebutuhan di sekolah dasar yang masih kekurangan pengadaan bahan ajar multimedia interaktif. Instrumen yang digunakan meliputi angket minat belajar, lembar observasi untuk menilai keaktifan siswa, wawancara untuk menggali umpan balik dari guru maupun siswa, serta dokumentasi proses dan hasil pembelajaran. Teknik pengumpulan data melalui observasi, pengisian angket, wawancara, serta analisis hasil dokumentasi dan implementasi bahan ajar. Hasil penelitian menunjukkan bahwa bahan ajar multimedia interaktif efektif dalam meningkatkan minat belajar siswa. Penggunaan bahan ajar ini signifikan dalam minat peningkatan belajar siswa, dengan antusiasme yang lebih tinggi selama pembelajaran. Pendekatan diferensiasi memungkinkan siswa belajar sesuai dengan gaya belajar mereka, menjadikan materi lebih menarik dan dinamis. Penelitian ini menyimpulkan bahwa bahan ajar SISPERMA berbasis diferensiasi efektif dalam meningkatkan kualitas pembelajaran IPAS, khususnya pada materi sistem pernapasan siswa kelas 5 SD.
PENGEMBANGAN BUKU CERITA SAINS BERGAMBAR UNTUK PEMBELAJARAN ILMU PENGETAHUAN ALAM DAN SOSIAL (IPAS) KELAS III SEKOLAH DASAR
Authors: Wijaya I Komang Wisnu Budi , Wahyuni Ni Nyoman Tri , Yasa I Made Wiguna , Suastini Ni Nyoman , Santi Ening Manika
Published: December 2024

Penelitian ini bertujuan untuk mengembangkan buku cerita sains bergambar untuk pembelajaran IPAS Kelas III Sekolah Dasar dan menguji validitas dan kepraktisan buku cerita sains bergambar yang dikembangkan. Penelitian ini tergolong dalam penelitian pengembangan. Tahapan penelitian menggunakan model 4D yaitu define, design, develop and disseminate. Penelitian ini dilakukan di SD Negeri 5 Mas Ubud, Kabupaten Gianyar, Provinsi Bali. Instrumen penelitian ini menggunakan lembar validitas dan lembar kepraktisan. Data hasil penelitian dianalisis secara deskriptif. Hasil penelitian menyatakan bahwa buku cerita sains bergambar yang dikembangkan terdiri dari 12 (dua belas) cerita sains untuk menanamkan 7 (tujuh) konsep IPAS dan dilengkapi dengan gambar animasi, alur cerita dan kolom konsep sains dan buku cerita sains bergambar yang dikembangkan memenuhi syarat validitas dan kepraktisan. Kesimpulan dari penelitian ini adalah buku cerita sains bergambar yang dikembangkan oleh peneliti layak digunakan dalam pembelajaran IPAS khususnya siswa kelas III.
EFEKTIVITAS LKPD BERBANTUAN QUIZIZZ DALAM PEMBELAJARAN BAHASA INGGRIS DI SMK NEGERI 4 BANGLI
Authors: Maharani Ni Putu Diah , Sueca I Nengah
Published: December 2024

Penelitian ini bertujuan untuk menyalakan seberapa efektif penggunaan LKPD berbantuan Quizizz dalam meningkatkan kualitas pembelajaran Bahasa Inggris di lingkungan SMK serta dapat menentukan kelayakan penggunaan Quizizz sebagai media pembelajaran dalam interaktif membantu siswa menjawab soal dan memahami materi. menggunakan metode campuran ( Mixed Method ) yang menggabungkan pendekatan kuantitatif dan kualitatif dalam satu penelitian. Metode campuran memungkinkan pengumpulan data yang lebih kaya dan analisis yang lebih mendalam, sehingga menghasilkan hasil yang komprehensif, valid, konsisten, dan obyektif. Penelitian ini melibatkan siswa SMK N 4 Bangli, terdiri dari 32 siswa dari kelas X Kuliner II serta wali kelas mereka, yang bertindak sebagai informan pendukung untuk memberikan informasi tambahan. Penelitian ini menggunakan metode purposive sampling untuk pemilihan subjek. Observasi, wawancara, dan tes adalah metode pengumpulan data yang digunakan. Hasil belajar siswa menunjukkan nilai rata-rata yang tinggi dan sebagian besar siswa mencapai kategori Sangat Baik (85,4%), menunjukkan penguasaan materi yang optimal. Observasi dan wawancara dengan siswa menunjukkan bahwa mereka lebih tertarik dan termotivasi dalam mengikuti pembelajaran dengan menggunakan Quizizz, berpikir lebih menarik dan interaktif dibandingkan metode tradisional.
The Birth And Evolution Of The Bottled Water Market In Italy Until The World War II
Authors: Colzi Francesco
Published: December 2024

This paper presents the initial findings of an ongoing research project examining the birth and evolution of the Italian bottled water market until the WWII through an analysis of a variety of documentary sources. The study examines the development of the production and consumption of this fundamental commodity, with a particular focus on the economic, social and cultural variables that affected supply and demand. The paper reveals that the growth of the industry during the period under examination - which commenced at the inception of the country's overall developmental trajectory - was constrained by two key factors. Firstly, the prevailing inefficiency of the system - characterized by a fragmented market, small size enterprises and high production costs - limited the potential for expansion. Secondly, the gradual shift in consumer preferences, which was largely aligned with the traditional perception of mineral water as a medicinal product. Consequently, despite the undeniable expansion of the sector, the scale of production remained relatively limited, and the domestic consumption persisted at a modest level, failing to become a daily habit.
Analyse Des Facteurs De Satisfaction Des Clients Face À L’utilisation Des Services Bancaires Digitaux
Authors: Yaya CISSÉ Dr Mamady , KPOGHOMOU Dr Makolo
Published: December 2024

This study aims to analyze the impact of the digitalization of financial governance on customer satisfaction. It is based, in particular, on banking operations related to the payment of salaries of civil servants at the counters of the VISTA Guinea bank (VISTA Gui). The results are based on quantitative data from a survey of 350 paid civil servants in the Agencies of this targeted institution. This study shows that customer satisfaction depends on the effectiveness of digital banking services, trust in the bank, customer loyalty and the perception of innovation within the bank.
Modelado y optimización de la fermentación en estado sólido: El poder de la inteligencia artificial en procesos biotecnológicos
Authors: Beatriz-Cuellar Hugo , Martínez-Trujillo María Aurora , Membrillo-Venegas Isabel de la Luz
Published: December 2024

Este trabajo describe las características, los beneficios y el procedimiento del modelado y la optimización de procesos de fermentación en estado sólido (FES) mediante sistemas de inteligencia artificial (IA). En este artículo se describen las características de las redes neuronales artificiales para modelar un proceso; así como del algoritmo genético y la optimización por enjambre de partículas para determinar los valores óptimos de las variables independientes del proceso. Además, se señalan los requerimientos para implementar estos sistemas de IA en un proceso de FES. La propuesta se basa en la facilidad que supone el hecho de que estos sistemas de IA no requieren operaciones matemáticas complejas, ya que utilizan conceptos e ideas de la naturaleza para solucionar problemas a partir del uso de un conjunto de datos o medidas del proceso. Como su funcionamiento es simple de entender e implementar, el uso de estas técnicas de IA en la FES puede ser de gran utilidad para predecir de manera más precisa el comportamiento del proceso, reducir los errores, ahorrar tiempo y hacer un uso más eficiente de los recursos disponibles.
Teknologi Smart Digester untuk Mengembangkan Budaya Mandiri Energi Bagi Warga Desa Banjarsari Kabupaten Madiun
Authors: Nurmalasari Riana , Siswanto Ely , Sunaryo Nonny Aji , P. P. S Gladis Viona
Published: December 2024

Salah satu wilayah di Kabupaten Madiun yang sebagian besar penduduknya memiliki hewan ternak yaitu di Kecamatan Madiun tepatnya di Desa Banjarsari. Namun sayang, banyaknya warga yang memiliki hewan ternak belum diimbangi dengan pengelolaan maupun pengolahan limbah kotoran hewan dengan baik. Padahal jika dikelola dan diolah dengan benar, limbah kotoran hewan ternak memiliki manfaat dan dapat menghasilkan nilai ekonomis. Salah satu upaya pengelolaan dan pengolahan limbah kotoran hewan ternak yang baik yaitu dengan memanfaatkannya sebagai sumber energi seperti biogas. Biogas yang dihasilkan dari limbah kotoran hewan ternak dapat dimanfaatkan untuk pemenuhan kebutuhan energi harian masyarakat. Untuk menghasilkan kualitas biogas yang baik diperlukan teknologi untuk memproses dan mengolahnya yaitu digester. Berdasarkan hasil pengolahan limbah kotoran ternak, diketahui kapasitas dari tong digester yaitu 150 – 200 liter. Kapasitas kantong biogas 500 liter. Pada kondisi penuh kantong biogas mampu menghasilkan gas untuk memasak 60 hingga 120 menit. Kondisi ini memungkinkan masyarakat untuk mampu menghasilkan energi secara mandiri dengan memanfaatkan kotoran ternak untuk kepentingan sehari-hari.
Peningkatan Pengetahuan Tentang Prinsip Gizi Seimbang pada Siswi Kelas X SMA Sejahtera 1 Depok
Authors: Puspita Sari Dian , Sitoayu Laras , Meiliana Yutta Lilin Sabad , Ramadhan Muhammad Rizzqi
Published: December 2024

Saat ini Indonesia sedang menghadapi tiga beban masalah gizi yaitu masalah gizi kurang, gizi lebih dan kekurangan zat gizi mikro. Pendidikan juga merupakan salah satu faktor utama terjadinya masalah gizi. Kegiatan ini bertuuan untuk meningkatkan pengetahuan mengenai gizi seimbang pada remaja putri. Kegiatan edukasi ini dilakukan secara tatap muka dengan metode ceramah menggunakan media powerpoint dan poster isi piringku dan permainan puzzle isi piringku. Hasil dari penelitian ini adalah rata rata nilai pretest adalah 58 dan rata-rata nilai posttest adalah 76, sehingga didapatkan peningkatan skor sebesar 18 poin. Berdasarkan hasil tersebut membuktikan bahwa pengetahuan siswa terkait gizi dapat meningkat dengan adanya kegiatan ini, namun tidak akan mengubah sikap dan perilaku nya secara signifikan dalam waktu yang singkat, sehingga penting dilakukan kegiatan edukasi serupa untuk terus memperbarui dan menambah ilmu gizi pada remaja.
Daur Ulang Sampah Anorganik di Cengkareng Jakarta Barat
Authors: Yuliarty Popy , Utami Diah , Dwiasnati Saruni
Published: December 2024

Aktifitas PkM ini dimaksudkan untuk menambah ilmu dan keterampilan dalam pengelolaan sampah anorganik di lokasi mitra dan sekitarnya. Solusi dari masalah sampah anorganik di sekitar lokasi mitra adalah memberikan edukasi, pemahaman pentingnya pemilahan sampah sejak dari rumah sampai di tempat umum misalnya disekolah, memberikan wawasan tentang nilai yang masih dimiliki oleh sampah ini dari sisi ekonomisnya dan memberikan praktek menghasilkan benda dari sampah yang masih bisa digunakan. Metode pelaksanaan yaitu observasi ke lokasi, persiapan, pelaksanaan dalam dua sesi besar yaitu pemberian materi teori dan praktek pembuatan produk daur ulang. Evaluasi kegitan dengan menyebarkan kuisioner kegitan. Luaran nyata yang diharapkan yaitu produk hasil daur ulang sampah bungkus plastik dan memberikan apresiasi kepada peserta dengan hasil produk daur ulang terbaik. Kesimpulan dari kegiatan PkM ini adalah  terdapat beberapa permasalahan yang dihadapi oleh Mitra yaitu: Mitra merupakan salah satu tempat yang berpotensi menghasilkan sampah anorganik yang besar cukup karena jumlah siswa yang banyak, dan berada di lingkungan pemukiman yang sangat padat, berdekatan pula denga Pasar Besar Cengkareng, sehingga perlu melakukan pengelolaan sampah anorganik.
Assessment of Drought Tolerance in Rice Landraces via Seedling-Based Indices
Authors: B.K. Bibas , Dahal Sneha , Pradhan Nirmala
Published: December 2024

Landraces serve as a vital reservoir of genetic diversity, offering allelic variation crucial for breeding resilient cultivars. However, with the increasing frequency and intensity of drought due to climate change, identifying drought-resilient rice varieties is crucial to ensure sustainable rice production. Although, Nepal hosts a vast diversity of rice landraces, yet their potential for drought stress tolerance remains underexplored. This study evaluated 25 rice landraces for drought tolerance at the seedling stage using a completely randomized design (CRD) in 250 ml disposable cups under three moisture regimes: 60% field capacity (FC), 100% FC, and saturated conditions. Ten quantitative traits were analyzed, and significant variation was observed among landraces and across moisture conditions. Correlation analysis suggested that, under 60% FC, root length showed a significant positive correlation with shoot length, root: shoot ratio, and fresh root weight, whereas a negative correlation was noted between root: shoot ratio and root number. Germination percentage remained unaffected by moisture conditions. Principal component analysis revealed a positive connection of root length and root-to-shoot ratio towards 60% FC, while shoot length, fresh weight, dry weight, and root number were associated with saturated conditions. Among the landraces, Manamurey demonstrated superior performance across studied traits. These findings highlight the potential of specific landraces for drought resilience and emphasize the need for further evaluations at vegetative and reproductive stages to confirm their utility in breeding programs.
Borderline Kişiliklerin Terapisinde Aktarım, Karşı Aktarım, Yansıtmalı Özdeşim ve Sağ Beyin
Authors: Topaloğlu Yunus , Kıyga Emine
Published: December 2024

Borderline Kişilik Bozukluğu (BKB), bireyin kendilik algısı, duygulanımı ve ilişkilerinde tutarsızlıklarla tanımlanır. Bu bozukluk, terk edilmekten kaçınma, dengesiz ilişkiler, kimlik karmaşası, dürtüsellik, intihar girişimleri ve yoğun öfke gibi belirtilerle kendini gösterir. Borderline Kişilik Örgütlenmesi ise kimlik dağınıklığı, ilkel savunma mekanizmalarının kullanımı ve gerçekliği değerlendirme yetisinde kısmi bozulma ile karakterizedir. Borderline Kişiliğin ilişkilerinde ve terapisinde sıklıkla kullanılan yansıtmalı özdeşim mekanizması, kişinin dayanılmaz bulduğu içsel nesneleri karşısındakine yansıttığı ve onu bu içsel nesnelere gerçekten sahipmiş gibi davranmaya zorladığı bir durumdur. Aktarım ve karşı aktarım tepkileri borderline kişiliğin tedavisinde önemli bir rol oynamaktadır. Terapi ilişkisinde ortaya çıkan aktarım, içselleştirilmiş nesne ilişkilerinin şimdi ve burada yeniden sahnelenmesiyken, karşı aktarım terapistin kişisel geçmişine ve hastanın aktarımına bağlı olarak ortaya koyduğu tepkilerdir. Aktarım, karşı aktarım ve yansıtmalı özdeşim gibi mekanizmalarla ilişkili olan beynin sağ yarımküresi, temelde duygu düzenleme ile ilişkilidir ve erken dönemde içselleştirilmiş ilişki kalıplarını içermektedir. Bu çalışmada borderline kavramı çeşitli perspektiflerde ele alınmış olup aktarım, karşı aktarım, yansıtmalı özdeşim ve nörogelişimsel kuram çerçevesinde bir inceleme yapılmıştır.
Cultural Heritage and Educational Practices: A Conceptual Study of Cantonese Folk Song Education in Guangdong Province
Authors: Xiaozhi Xie , Maniam Sumathi A/P
Published: December 2024

This paper explores the intersection of cultural heritage and educational practices in the teaching of Cantonese folk songs in Guangdong Province. It examines the cultural significance of Cantonese folk songs as vital components of Guangdong's intangible cultural heritage and evaluates both formal and informal educational practices that support the transmission of these traditions. The study identifies key challenges, including limited resources, declining youth engagement, and the integration of folk songs into standardized curricula. Additionally, the paper discusses innovative pedagogical methods, such as the use of digital platforms and multimedia tools, that can enhance the preservation and revitalization of folk music. It concludes by suggesting future research directions, including comparative studies of folk song education across regions, the role of technology in cultural transmission, and strategies for increasing youth engagement with traditional music. This research contributes to the ongoing discourse on cultural sustainability and the role of education in preserving intangible cultural heritage.
Penerapan Quantum Teaching dalam Pembelajaran Siswa MIN 13 Nagan Raya
Authors: Zubaili Zubaili , Mahmud Salami
Published: December 2024

Penelitian ini bertujuan untuk mengevaluasi efektivitas penerapan model pembelajaran Quantum Teaching dalam meningkatkan hasil belajar siswa pada mata pelajaran Ilmu Pengetahuan Alam dan Sosial (IPAS) di Madrasah Ibtidaiyah Negeri (MIN) 13 Nagan Raya. Quantum Teaching merupakan pendekatan inovatif yang dirancang untuk memaksimalkan keterlibatan siswa melalui integrasi teknik pembelajaran yang menyentuh berbagai dimensi pengalaman belajar, seperti motivasi, keterlibatan, dan penerapan konsep dalam konteks kehidupan nyata. Penelitian ini menggunakan metode kuasi-eksperimen dengan desain pre-test dan post-test untuk mengukur perubahan hasil belajar siswa sebelum dan setelah intervensi. Data penelitian dikumpulkan melalui tes hasil belajar, observasi kelas, wawancara dengan siswa dan guru, serta kuesioner tentang persepsi siswa terhadap pembelajaran. Hasil penelitian menunjukkan bahwa penerapan Quantum Teaching secara signifikan meningkatkan hasil belajar siswa. Selain itu, model ini juga meningkatkan motivasi, keterlibatan, dan pemahaman siswa terhadap materi IPAS. Penelitian ini merekomendasikan penerapan lebih luas Quantum Teaching sebagai strategi pembelajaran untuk meningkatkan kualitas pendidikan di berbagai jenjang sekolah.
An Analysis Of Students’ Difficulties In Writing Recount Text At Tenth Grade Students Of SMAN 5 Pontianak
Authors: Fernando Irfan , Purwaningsih Dewi Ismu , Yolanda Alvina
Published: December 2024

Penelitian ini bertujuan untuk menganalisis kesulitan yang dihadapi siswa kelas X di SMAN 5 Pontianak dalam menulis teks recount. Teks recount adalah genre tulisan yang menceritakan kembali peristiwa atau pengalaman masa lalu secara kronologis. Meskipun bersifat naratif, siswa sering kesulitan dengan berbagai aspek menulis teks recount, termasuk penggunaan bahasa, struktur, dan pengembangan konten. Penelitian ini menggunakan pendekatan kualitatif, memanfaatkan observasi, wawancara, dan analisis sampel tulisan siswa untuk mengumpulkan data. Temuannya menunjukkan bahwa kesulitan utama yang dihadapi siswa meliputi keterbatasan kosa kata, kesulitan dalam mempertahankan bentuk kata kerja yang tepat, kurangnya koherensi dan kohesi, dan tantangan dalam mengatur ide secara logis. Selain itu, siswa sering kali menunjukkan kurangnya pemahaman terhadap struktur teks recount, yang berdampak pada kualitas tulisan mereka secara keseluruhan. Studi ini menyimpulkan dengan menyarankan intervensi yang ditargetkan untuk mengatasi tantangan-tantangan ini, seperti program pengayaan kosa kata, latihan tata bahasa terfokus, dan instruksi eksplisit tentang struktur dan organisasi teks. Intervensi ini bertujuan untuk meningkatkan keterampilan menulis siswa dan kompetensi keseluruhan dalam memproduksi teks recount.
Kajian Perkembangan Kognitif Dan Psikologi Anak Pada Tingkat Sekolah Dasar Kelas Rendah
Authors: Purwulan Heni
Published: December 2024

Proses perkembangan kognitif pada anak mencakup kemampuan berpikir, memproses informasi, dan menyelesaikan masalah yang berkembang seiring waktu. Penelitian ini bertujuan untuk memberikan panduan dalam pengembangan kurikulum yang lebih baik dan strategi pembelajaran yang sesuai dengan tahap perkembangan kognitif anak. Penelitian ini menggunakan metode penilaian kualitatif dipilih atas pertimbangan situasi yang kompleks sedemikian rupa dan data diperoleh berdasarkan hasil observasi, wawancara dan dokumentasi.. Berdasarkan teori-teori seperti Piaget dan konsep-konsep penting dalam psikologi perkembangan, penelitian menemukan tahap-tahap perkembangan kognitif dari kelas 1 hingga kelas 3. Penekanan pada pentingnya pemahaman yang dalam terhadap perkembangan anak dalam konteks pendidikan anak sekolah dasar kelas rendah. Guru dan pendidik perlu memahami perbedaan individual dalam perkembangan anak-anak mereka untuk merancang strategi pengajaran yang efektif. Adapun aspek sosial dan emosional, abstrak ini menyoroti bagaimana anak-anak pada usia ini mulai mengembangkan hubungan sosial dan kemampuan untuk mengatur ekspresi emosi mereka secara sosial diterima. Implikasi praktis dari penelitian ini adalah meningkatkan pendidikan anak usia sekolah dasar dengan memperhatikan karakteristik individu mereka, memungkinkan pendidik untuk memberikan dukungan yang lebih baik dan efektif selama proses pembelajaran mereka.
Denitive brachytherapy in localized prostate cancer – treatment outcomes and prognostic values of prostate- specic antigen
Authors:   Radiotherapy Department, USBALO, Sofia, Bulgaria, Genova Boryana
Published: December 2024

Brachytherapy in localized prostate cancer is alternative to radical prostatectomy, and the choice should be in accordance with the patient‘s decision when reporting the expected treatment results, complications and quality of life. The reported results of applying low-dose brachytherapy with permanent implant are more long-lasting and indicate a 15-year biochemical control, assessed by PSA values, in 85-88% of treated patients. Data from high dose rate brachytherapy with temporary radioactive implants are with shorter follow-up. The disadvantage of assessing the results of the studies in the treatment of prostate cancer is related to the assessment of the treatment results by biochemical control, and not mortality, as a more categorical indicator. This is due to the average age of the patients, the difficult differentiation of complications from frequently applied androgen deprivation therapy – hormonal treatment, concomitant diseases and the difficulty of distinguishing natural causes of the fatal outcome from specific tumor-related mortality. Prostate-specific antigen (PSA) values determine the prognosis during the course of the disease to a significant extent, as well as in monitoring the disease-free period. After radical prostatectomy, persistence of PSA is an expression of non-radical treatment behavior or undetected distant metastasis. While in radiotherapy and the various methods – external beam or brachytherapy due to the preservation of the parenchyma of the gland and the specific response to ionizing radiation depending on the size of the dose fraction, PSA continues to be detected long after the treatment. The pretreatment-initial level of the tumor marker is also important for this. The serious difficulty of using the marker in the follow-up of radiotherapy results has been demonstrated in numerous retrospective studies comparing local methods such as radical prostatectomy, percutaneous radiotherapy and brachytherapy or combined radiotherapy. The aim of the review is to present the results after different types of brachytherapy in localized prostate cancer and the data available in the literature on the follow-up of patients after brachytherapy with PSA values, their kinetics over time and their prognostic significance.
Primary hyperoxaluria
Authors:   Department of Urology, National Oncology Hospital, Sofia, Bulgaria, Tahchiev Metodi , Neykov Krasimir ,   Department of Urology, National Oncology Hospital, Sofia, Bulgaria
Published: December 2024

Primary hyperoxaluria (PH) can lead to the formation of kidney stones. When oxalate binds to calcium in the urine, calcium oxalate is produced, which is the most common component of kidney stones. Primary hyperoxaluria is a group of rare genetic disorders causing loss of specific enzyme activity. In turn, this leads to the formation of a large amount of oxalate. 3 types of primary hyperoxaluria have been identified. The first type is the most common, occurring in 80 percent of cases. It leads to end-stage renal failure in childhood. The missing enzyme is alanine-glyoxylate aminotransferase (AGT). Type 2 is significantly less common, with a much more favorable prognosis. Adding pyridoxine to therapy improves results. The missing enzyme is glyoxylate reductase/hydroxy pyruvate reductase (GRHPR). Type 3 is considered to have a favorable prognosis, due to mutations in the HOGA1 gene. It rarely leads to end-stage renal failure. In the diagnosis of PH, laboratory tests, imaging and genetic tests are used. The treatment of PH is based on dietary regimen, high doses of pyrodoxine, magnesium-containing preparations, glycosaminoglycans. RNA interference agents have revolutionized treatment. In patients with end-stage chronic renal failure, dialysis is resorted to and an option for liver-kidney transplantation is discussed.
Metabolic surgery as a treatment for metabolic syndrome - a literature review and a clinical case.
Authors:   Department of Endocrinology, Acibadem City Clinic, Tokuda University Hospital, Soa, Terzieva Krista , Kalinkova Maria ,   Department of Endocrinology, Acibadem City Clinic, Tokuda University Hospital, Soa
Published: December 2024

Obesity is a pandemic that continues to spread as the world continues to modernize. Medical therapy is frequently utilized to help obese patients with weight reduction but is often insufficient for achieving meaningful and sustainable results. Weight loss surgery, also referred to as bariatric surgery, has been an option for treatment since the 1950’s. Throughout its long history, it has evolved from an era of high morbidity and mortality to one of laudable safety despite the high-risk nature of the patients undergoing these major gastrointestinal procedures. This article includes a history review of the different types of surgical techniques, discusses the need for plastic surgery after bariatric interventions and introduces a clinical case from our practice, in which the two procedures were applied.
Our experience with the application of the extraperitoneal laparoscopic burch colposuspension
Authors:   Division of Urology, Clinic of Surgery, Naval Hospital of Varna, Military Medical Academy of Soa, Terzi Vasil
Published: December 2024

Introduction: Recently, there is a considerable interest of the scientific community in the operative treatment of the female stress urinary incontinence, as until 2009, more than 200 surgical techniques have been described. Burch colposuspension and pubovaginal slings are recommended in the recent guidelines of the European Association of Urology.
Aim: We describe an extraperitoneal laparoscopic Burch colposuspension modified by us for the operative treatment of the female stress urinary incontinence. Material and Methods: During the period between November 2017 and August 2024, we operated on a total of 27 female patients in the Division of Urology and Gynecology, Clinic of Surgery of the Naval Hospital of Varna, Military Medical Academy of Sofia. They were at a mean age of 56,04±11,22 years (range, 36 to 75 years).
Results: Postoperative period was comparatively short. The patients were discharged with a considerable clinical improvement.
Conclusion: Our results enable us to draw the conclusion that the extraperitoneal laparoscopic Burch colposuspension modified by us is safe and effective. It could more widely be applied in the Bulgarian urological practice.
Postatrophic hyperplasia of the prostate: Current literature review and research perspectives
Authors:   Clinic of pathology, Military Medical Academy, Sofia, Bulgaria, Fakirova Albena
Published: December 2024

Nowadays, numerous reocurring epidemiologic, histopathologic and mo-
lecular-genetic evidence of the connection between chronic inamma-
tion and the socially signicant prostate diseases can be traced, such as
benign prostate hyperplasia, prostate cancer and the prostatitis. At the
same time, however, for many years the intermediate link between the ini-
tial process (chronic inammation) and the end stage (prostate cancer) of

the morphogenesis of the process was not clearly dened. Nevertheless,
owing to the extensive and comprehensive research that has been con-
ducted in the last 25 years, this gap has now been narrowed, and new his-
tological entities have appeared, namely inammatory proliferative atrophy
and postatrophic hyperplasia (PAH). The plethora of terminology, associat-
ed with PAH, includes secondary hyperplasia, hyperplastic atrophy, lobular
hyperplasia, small acinar proliferation and atrophy, assotiated with hyperplasia.
The purpose of this article is to provide an overview of the current morphological
and immunohistochemical characteristics of PAH, drawing from the existing lit-
erature on this topic. A summary of suggestions for further research in the future
is also included.
Iatrogenic high-flow femoral AV fistula – A clinical case
Authors:   Military Medical Academy of Sofia, Bulgaria, Clinic of Vascular Surgery, Marmarov Petar , Kolev Nikola ,   Military Medical Academy of Sofia, Bulgaria, Clinic of Vascular Surgery, Tsekov Milan ,   Military Medical Academy of Sofia, Bulgaria, Clinic of Vascular Surgery, Marangozov Svetozar , Naydenova Todorka ,   Military Medical Academy of Sofia, Bulgaria, Clinic of Vascular Surgery, Girov Kuzman ,   Military Medical Academy of Sofia, Bulgaria, Clinic of Vascular Surgery
Published: December 2024

Arteriovenous fistula (AVF) was first described in medicine by William Hunter in 1757, followed by the first surgical attempt at its correction in 1837 by Breschet, who attempted to eliminate the fistula by ligation of the proximal artery. As minimally invasive procedures and the wide variety of endovascular devices have increased, so have post-procedural complications. Post-procedural arteriovenous fistula in the inguinal region is a relatively rare complication, which in its evolution could lead to congestive heart failure and changes in tissue perfusion of the lower limb due to the direct passage of blood from the arterial to the venous system.
Combined treatment gamma knife radiosurgery and immunotherapy in a patient with brain metastases from malignant melanoma
Authors:   Department of Radiotherapy and Radiosurgery, Heart and Brain Center of Clinical Excellence – Pleven, Cholakova Maria , Zhelev Kiril ,   Department of Radiotherapy and Radiosurgery, Heart and Brain Center of Clinical Excellence – Pleven, Mihaylova Maria ,   2 Department of Nuclear Medicine, USHATO “Prof. Ivan Tzernozemsky”– Soa
Published: December 2024

Melanoma is a complex disease with a high propensity for brain metastatic spread. Gamma Knife radiosurgery (GKRS) is a minimally invasive procedure to treat intracranial metastasis with a high rate of local tumor control. In this report, we describe the ongoing management of a patient with the development of brain metastases that required GKRS procedures for a total of 17 brain metastases receiving concurrent immunotherapy with pembrolizumab. The first imaging of the patient showed better local control after GKRS. Combined management with immunotherapy and GKRS for brain metastases resulted in extended survival while preserving neurological function and reducing adverse treatment effects in a patient with advanced metastatic brain melanoma.
Postoperative Analgesia and Length of Hospital Stay After Surgery for Malignant Pleural Mesothelioma: A Retrospective Observational Study
Authors: Kobata Mayuu , Takeda Kenta , Taguchi Mana , Okutani Hiroai , Ide Takeshi , Kido Akane , Fujimoto Kouichi , Hashimoto Masaki , Ueki Ryusuke , Hirose Munetaka
Published: December 2024

Background: Pleurectomy/decortication (P/D), a surgical procedure for malignant pleural mesothelioma (MPM), is a highly invasive surgery requiring prolonged hospitalization. Previous studies have reported that postoperative analgesia using regional anesthesia contributes to shorter hospital stays after surgery under general anesthesia by reducing acute postoperative pain. However, the association between postoperative analgesia and the length of hospital stay (LOHS) following P/D has not been evaluated. Objectives: To evaluate the association between postoperative analgesia and postoperative LOHS after P/D. Methods: This single-institution observational study enrolled consecutive adult patients undergoing P/D under general anesthesia, who postoperatively received either intertransverse process block (ITPB) or continuous intravenous (IV) fentanyl infusion as postoperative analgesia between March 2022 and February 2023. Results: Among all enrolled patients with ASA physical status II or III (n = 60), postoperative analgesia was administered using either continuous ITPB (n = 19) or continuous IV fentanyl infusion (n = 41). Multivariable logistic regression analysis revealed that postoperative analgesia with continuous ITPB (P = 0.007), a lower incidence of major complications after surgery (P = 0.034), and female sex (P = 0.033) were significantly associated with a shorter postoperative LOHS. In subgroup analysis, patients who received continuous ITPB had significantly lower postoperative LOHS, lower postoperative serum C-reactive protein levels on postoperative day (POD) 3, and reduced acute postoperative pain on POD3 compared to those who received continuous IV fentanyl infusion. Conclusions: Postoperative analgesia using continuous ITPB appears to be associated with a reduction in LOHS following P/D for MPM under general anesthesia.
Successful Surgical Management of Mediastinal Ganglioneuroma in a 12-Year-Old Boy: A Case Report
Authors: Khoshkhabar Mahmood , Ilkhani Pak Hoda , Peyvasteh Mehran , Askarpour Shahnam , Ghaedamini Hossein
Published: December 2024

Introduction: Ganglioneuromas (GNs) are benign tumors composed of gangliocytes and mature stroma which is usually asymptomatic. The GNs are differentiated neuronal tumors without immature elements and can arise from peripheral autonomic ganglion sites. The main treatment for that is complete surgical excision. In the case of tumor resection, chemotherapy and radiotherapy are not indicated. Case Presentation: The 12-year-old boy was referred to Abouzar Hospital in Ahvaz with complaints of cough, cold, and shortness of breath. Based on abdominal and pelvic CT scans, a heterogeneous hypodense mass (135 × 105 mm) was observed in the left upper region. The pathology of it was ganglioneuroma. Then the patient underwent surgery with a midline incision extending to the 6 - 7 intercostal space. Finally, the patient was discharged with good general condition. Conclusions: The most effective treatment for ganglioneuroma is complete surgical removal of the mass. This study highlights the importance of imaging in diagnosing ganglioneuroma as a tumor located in the posterior mediastinum.