bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring behaviours perceived as important for human—dog bonding and their translation to a robotic platform
Authors: Riddoch Katie , Hawkins Roxanne D , Cross Emily S.
Published: September 2021

To facilitate long-term engagement with social robots, emerging evidence suggests that modelling robots on social animals with whom many people form enduring social bonds – specifically, pet dogs – may be useful. However, scientific understanding of the features of pet dogs that are important for establishing and maintaining social bonds remains limited to broad qualities that are liked, as opposed to specific behaviours. To better understand dog behaviours that are perceived as important for facilitating social bonds between owner and pet, we surveyed current dog owners (n = 153) with open-ended questions about their dogs’ behaviours. Thematic analysis identified 7 categories of behaviours perceived as important to human-dog bonding, including: 1) attunement, 2) communication, 3) consistency and predictability, 4) physical affection, 5) positivity and enthusiasm, 6) proximity, and 7) shared activities. We consider the feasibility of translating these behaviours into a social robotic platform, and signpost potential barriers moving forward. In addition to providing insight into important behaviours for human—dog bonding, this work provides a springboard for those hoping to implement dog behaviours into animal-like artificial agents designed for social roles.
3-Step ML Auxiliary Variable Integration Using MplusAutomation
Authors: Garber Adam C
Published: September 2021

This R tutorial automates the 3-step ML axiliary variable procedure (Vermunt, 2010) using the MplusAutomation package (Hallquist & Wiley, 2018) to estimate models and extract relevant parameters. To learn more about auxiliary variable integration methods and why multi-step methods are necessary for producing un-biased estimates see Asparouhov & Muthén (2014). For an accessible description of the 3-step ML method applied in the context latent transition analysis see Nylund-Gibson et al. (2014). The BCH method (Bolck et al., 2004) can also be implemented with MplusAutomation (see tutorial; https://psyarxiv.com/wmfcj). Although the BCH outperforms the 3-step approach, in many applied contexts it cannot be implemented due to the estimation of negative weights. The motivation for writing this tutorial is that conducting the 3-step manually is highly error prone as it requires pulling logit values estimated in the step-1 model and adding them in the model statement of the step-2 model (i.e., lots of copying & pasting). In contrast, this approach is fully replicable and provides clear documentation which translates to more reliable research.
Measuring Navigational Map Reading Competencies: A Pilot Study with a location-based GeoGame
Authors: Bistron Janina , Schwering Angela
Published: September 2021

Navigational map reading (NMR) is relevant to people’s everyday life, in professional contexts, and in school education. Being interested in fostering children’s NMR competencies implies a test instrument for measuring potential learning progress. Related literature lacks an evaluated test for children that is focused on the spatial aspects of NMR and applicable at different locations. This paper fills this gap by presenting OriGami NMR Test – a test for measuring NMR competencies in children that is implemented in a digital geogame and played with a mobile device in the real-world. In order to enable a transfer of the test to different locations, we offer the reader the general concept of the test, the geogame, as well as a script that automatically scores the participants’ test performances and evaluates the test items for the specific location. In a pilot study, we successfully realized and evaluated the test for two different locations. [Note: The app "OriGami" was renamed to "GeoGami"!]
Validity and reliability of plant-based culinary nutrition model questionnaire for fitness among sports science students
Authors:   Centre for Sport and Exercise Sciences, University of Malaya, 50603 Kuala Lumpur, Malaysia, Baboo Morji Bina , Abdul Razak Ahmad Zabidi ,   Department of Educational Management, Planning and Policy, Faculty of Education, University of Malaya, 50603 Kuala Lumpur, Malaysia, Hamzah Sareena Hanim ,   Department of Educational Management, Planning and Policy, Faculty of Education, University of Malaya, 50603 Kuala Lumpur, Malaysia
Published: September 2021

Introduction: There is an emerging focus on plant-based foods that have the added advantage of being nutritious without side effects. Besides, its preparation with nutritional awareness and culinary skills could be an effective solution for improving personal fitness. This study aimed to determine validity and reliability of a questionnaire for the development of a plant-based culinary nutrition model for fitness among sports science students. Methods: This study employed exploratory sequential mixed method design and was carried out in two phases. Phase 1 employed a qualitative design utilising modified Delphi method to determine content validity index (CVI) of the questionnaire, while phase 2 was a quantitative design using Cronbach’s alpha statistical analysis to evaluate reliability of the instrument. The questionnaire consisted of the need for plant-based culinary nutrition model (Section A) and the model’s components (Section B). Thirteen expert panels from diverse expertise in sports nutrition and 30 sports science students took part. Results: Phase 1 resulted in development of a questionnaire where Section A and Section B scored CVI of 0.834 and 1.000, respectively. For phase 2, Cronbach’s alpha score for reliability of the questionnaire was 0.836 with a total of 15 items. The Cronbach’s alpha score for questionnaire items from Sections A and B were 0.709 and 0.832, respectively. Conclusion: The questionnaire developed in this study is validated and is considered reliable for use as a significant tool for plantbased culinary nutrition among sports science students.
Ciceronian Ethos and Clerical Masculinity in the Regensburg Rhetorical Letters
Authors: Newman Jonathan M.
Published: September 2021

The Regensburg Rhetorical Letters are fictional letters composed in the 1080s at the Regensburg cathedral school. They imitate Ciceronian texts to fashion a valorized masculine identity based in learning, eloquence, and public service for secular clerics in civil administration who were attacked for idleness and effeminacy by reformers like Peter Damian. Centering textual and rhetorical expertise, the Letters reveal the heterogeneity of clerical society and an early development of a professional rather than spiritual role for the clergy.
Investigation of 4-methyl-2.2-dioxo-1h-2λ6,1-benzothiazine-3-carboxamide derivative influence on the biochemical markers of gastric mucosa in rats
Authors: Malchenko О. V. , Voloshchuk N. І. , Pentiuk N. O.
Published: September 2021

Non-steroidal anti-inflammatory drugs occupy a leading position in the pharmaceutical market, but their class-specific side effect (ulcerogenic action) significantly limits their widespread use. The N-(4-methoxybenzyl)-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamide derivative (compound NI-9) showed a pronounced analgesic effect in various models of pain syndromes. The aim of the study was to determine the effect of a new original derivative of 4-methyl-2.2-dixo-1H-2λ6,1-benzothiazine-3-carboxylic acid on the macroscopic state and biochemical parameters of the gastric mucosa of rats. The study was performed on 51 male Wistar rats. Compound NI-9 and the reference drug meloxicam were administered intragastrically once daily for 28 days at doses of 3 and 5 mg/kg, corresponding to their ED50 analgesic activity. Macroscopic indicators of GM damage, glycosaminoglycan content, phospholipid profile, level of MDA and CGP, as well as nitrates and nitrites and H2S were determined. The results were processed in the program STATISTICA 10.0 using non-parametric methods. The results showed that the carboxamide derivative was safer for the stomach because the ulcer index of compound NI-9 was 1.73 times lower than that of meloxicam. The damaging effect of the compound was more pronounced at the pre-epithelial and epithelial levels of GM protection, while the post-epithelial level (production of vasodilating molecules NO and H2S) was practically unaffected by this derivative, unlike meloxicam, which caused damage at all levels of protection. The obtained data supplement the data on the pharmacodynamics of the 4-methyl-2.2-dixo-1H-2λ6,1-benzothiazine-3-carboxylic acid derivative and determine the expediency of its further studies as a potential non-opioid analgesic.
Investigation of pharmacokinetics of N-(4-trifluoromethylphenyl)-4-methyl-2.2-dioxo-1H-2λ6.1-benzothiazine-3-carboxamide various crystalline modifications in vivo
Authors: Bondarenko P. S. , Voloshchuk N. I. , Larionov V. B. , Fedoseenko H. О.
Published: September 2021

The phenomenon of polymorphism, inherent in many biologically active substances, including drugs, is an extremely serious problem that requires close attention and comprehensive study. Various crystalline modifications of biologically active compounds, as well as excipients can dramatically change the biopharmaceutical properties and pharmacological characteristics of already known drugs. The bioactive compound N-(4-trifluoromethylphenyl)-4-methyl-2.2-dioxo-1H-2λ6.1-benzothiazine-3-carboxamide was obtained by bioisosterical substitution in the molecule of known non-steroidal anti-inflammatory drugs of the oxycam group in the form of three polymorphic modifications of the crystal. sticks (form A), plates (form B) and blocks (form C) with varying degrees of analgesic and anti-inflammatory effects. The aim of the study was to investigate the pharmacokinetic profile of these polymorphic forms of benzothiazine-3-carboxamide derivative by their oral administration in vivo. The concentration of compounds in the blood of mice was determined by HPLC and the main pharmacokinetic parameters were calculated. It was found that the polymorphic form in the form of plates (form B), in particular, having the largest surface area of crystals, has differences mainly at the stage of absorption with corresponding changes in absorption values, maximum concentration and time of its achievement, has the highest bioavailability and rapid elimination which correlates with the most optimal pharmacological and toxicological characteristics of this compound in comparison with other crystalline forms. This makes it possible to recommend the most active and safe polymorphic form of the compound (form B) for in-depth preclinical study and possible clinical trials as an analgesic and anti-inflammatory agent.
Primary Localised Amyloidosis of the Urethra: A Case Report
Authors: Malde Sachin , Khan Nawal , Ahmed Kamran , Horsfield Catherine , Malde Sachin , Shabbir Majed
Published: September 2021

Primary localised amyloidosis of the urethra is a rare entity with only 50 cases reported in the literature. The
deposition of fibrillary proteins can lead to a range of symptoms. Importantly, the clinical and cystoscopic
features may mimic urethral malignancy (haematuria, voiding difficulties, and a palpable urethral mass),
and so thorough investigation is required in order to exclude malignancy, and to identify features of
generalised amyloidosis which has a poor prognosis. Once diagnosed the prognosis of localised amyloidosis
is excellent, although disease recurrence is possible. We describe a case of primary localised urethral
amyloidosis presenting with visible haematuria and a urethral stricture and reviewed the literature regarding
management of this rare condition.
Repeated Middle Meningeal Artery Embolization for Chronic Subdural Hematoma Management: Case Report
Authors: Sigounas Dimitri , Sack Kenneth , Thomas George , Sigounas Dimitri
Published: September 2021

Aim: Middle Meningeal Artery (MMA) embolization has emerged as a viable neuroendovascular technique
for the management of chronic subdural hematoma (SDH). Comparative analysis of various endovascular
techniques for embolization is lacking. Guidance on operative techniques in situations of prior embolization
failure is rare.
Materials and Methods: In this case report, we present a patient with a chronic subdural hematoma that
failed previous coil embolization of the MMA. Digital Subtraction Angiography showed the previously
placed coil and continued distal flow to the dural membranes.
Results: Onyx liquid embolization was completed successfully, effectively halting both anterograde flow
to the MMA and retrograde flow from external circulation collaterals.
Conclusion: This case report suggests that in situations of MMA embolization failure, follow-up
angiography may be completed to determine if further embolization through other procedural techniques
may be possible. The angiographic images contained here highlight the advantages of liquid embolization
over coil embolization of the MMA in halting SDH angiogenesis.
The quality Targeting of Cancer Chemotherapy Using Non-Invasive Focused Resonance Nano-Permeabilization
Authors: Garrepalli Saritha
Published: September 2021

Focused Resonance Nano-permeabilization (FORN) (US Patent 9,616, 245 B2-Apr 11th 2017) enables the 'targeted' delivery of chemo-therapeutic molecules using a safe, non-invasive, whole-body therapeutic device. The prototype device houses a gantry with specialized, near field, radio-frequency (RF) antennae and guns to deliver instantaneous, magnetic resonance. Drug focusing and delivery was enabled using FORN in a patient with advanced, loco-regionally recurrent, metastatic, nasopharyngeal carcinoma (NPC). Nonionizing, safe, extraneous-source radio-frequencies (RF) were delivered in the presence of an instantaneous magnetic field, to create temporary drug molecular weight-specific nanopores in the cell membrane of target lesions, concurrently with systemic chemotherapy. The high frequency RF is timed and delivered to regions of interest (ROIs) to span peak plasma concentrations of infused chemotherapeutic drugs over multiple treatment cycles. FORN-enabled chemotherapy-related adverse event evaluation and tumor response based on PERCIST 1.0 reflected improved clinical, anatomical and metabolic outcomes and significantly reduced myelosuppression in the patient who received 6+1 Cycles of combination chemotherapy, over an extended period of time. Functional Assessment of Cancer Treatment-Head & Neck (FACT-H&N) / Quality of Life (QoL) and Karnofsky Performance Status (KPS) reflected overall patient well-being. Recurrent, loco-regional disease, nodal, hepatic and skeletal metastases showed dramatic response on PET-CT follow up. Concurrent chemo-radiotherapy (CCRT) as a treatment paradigm is the standard of practice in locally advanced nasopharyngeal carcinoma (NPC).
Consequence of ANASTROZOLE on Chemo therapy
Authors: Garrepalli Saritha
Published: September 2021

Prepared nanoparticles were characterized in terms of particle size, scanning electron microscope (SEM), fourier transform infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC). In-vitro release studies were performed in phosphate buffer saline pH 7.4 at 37˚±0.5˚C for 1month. The mean particle size of obtained nanoparticles was 150-400 nm and was apparently spherical in shape, with smooth surface. DSC is done for the stability test for pure drug and sample. The thermogram of drug has not shifted for in the formulation compare to pure drug thermogram hence, the stability of formulation is not changed. FT-IR studies demonstrated that the drug was not changed in the formulation during the fabrication process.The encapsulation efficiency was about 48%. The Anastrozole-BSA nanoparticles exhibit a most interesting release profile with small initial burst followed by slower and controlled release.
Global Patterns of Lung Cancer Incidence
Authors: Garrepalli Saritha
Published: September 2021

Introduction It is well known that smoking is injurious to health which causes lung cancer. Although not all smokers develop lung cancer, fraction of lifelong non-smokers will die from lung cancer. Lung cancer is a major cause of cancer related death in developed countries with extremely poor overall survival rate. In present study we set out epidemiological pattern with clinical profile of lung cancer patients in northern india population. Aim:We evaluate the effect of smoking with age distribution on histopathology in lung cancer patients. Material & Methods: We enrolled 218 patients after confirmation of histopathology and also collected demographic data. Results: Out of 218 patients of lung cancer, having median age of 56 years, we found 149 (68.3%) were smokers and 69 (31.6%) were nonsmokers. In histopathology 54.1% patients had squamous cell carcinoma, 29.2% adenocarcinoma, 12.4% Mixed cell, 3.7% Small cell. We also found 63.1% smoker to have squamous cell carcinoma and 50.7% non-smoker have adenocarcinoma.In our study middle age group patients were more frequent in smoking group. While higher age group patients has squamous cell and middle group have adenocarcinoma. Therefore patients group with high smoking are found to develop have more risk to develop small cell carcinoma rather than in case of non-smoker higher age groups have sqamous cell carcinoma type. Conclusion: In this study we found middle age group subjects of smoker having more squamous cell and nonsmoker having adenocarcinoma.
Selected Sudanese Medicinal Plants Induce Anticancer and Cytotoxic Effects in Cervical Cancer Cell Line
Authors: Elnour Montasir
Published: September 2021

Modern pharmacology, however, relies on refined chemicals - either obtained from plants, or synthesized. This work investigated the anticancer, antioxidant and Cytotoxicity activities of N. lotus leaves citrate, N. lotus leaves not citrate, P. juliflora leaves commonly used as anti-inflammatory and Ant diabetic. All the plant parts were extracted using 80% methanol, the anticancer activity was examined by using MTT assay against Hela (Cervical Cancer) Cell Line. And determine their antioxidant activities by testing DPPH cytotoxicity using - (4, 5-Dimethyl thiazole-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT), filter and kept in dark, prepared freshly. The examined plants methanolic extracts of P. juliflora leaves is high activity against Hela (Cervical Cancer) Cell Line IC50 is 56.02 µg/ml. The extract C N. lotus leaves citrate, N. lotus leaves not citrate has shown none active anti- Hela (Cervical Cancer) IC50 values 100, and > 100 μg/ml respectively. All the extracts revealed cytotoxicity activity not toxic in N. lotus leaves citrate, N. lotus leaves not citrate, P. juliflora leaves the inhibition percentage with (90.81, 89.33074 , 86.47866 ) (73.17427 , 71.93975 , 60.17069 ) (74.93001, 73.78714 , 71.13981 ) respectively. The following plant parts showed highly potent scavenging activity against DPPH (above 80%); N. lotus leaves citrate, 88.78, While the following revealed a good activity against DPPH (between 60-79); N. lotus leaves not citrate, P. juliflora leaves with inhibition % are 77and 62.96 respectively.
Diagnosa COVID-19 Chest X-Ray Menggunakan Arsitektur Inception Resnet
Authors: Satyo Adhitio Satyo Bayangkari Karno , Arif Dodi , Kusuma Wardhana Indra Sari , Moreta Eka Sally
Published: September 2021

The availability of medical aids in adequate quantities is very much needed to assist the work of the medical staff in dealing with the very large number of Covid patients. Artificial Intelligence (AI) with the Deep Learning (DL) method, especially the Convolution Neural Network (CNN), is able to diagnose Chest X-ray images generated by the Computer Tomography Scanner (C.T. Scan) against certain diseases (Covid). Inception Resnet Version 2 architecture was used in this study to train a dataset of 4000 images, consisting of 4 classifications namely covid, normal, lung opacity and viral pneumonia with 1,000 images each. The results of the study with 50 epoch training obtained very good values for the accuracy of training and validation of 95.5% and 91.8%, respectively. The test with 4000 image dataset obtained 98% accuracy testing, with the precision of each class being Covid (99%), Lung_Opacity (97%), Normal (99%) and Viral pneumonia (99%).
Analisis Biaya Standar Sebagai Alat Pengendalian Biaya Tenaga Kerja Langsung pada PT Masaiki Jakarta
Authors: Suryani Rani , Srisulistiowati Dwi Budi
Published: September 2021

Setting wage rate standards based on the company's ability or agreement between employees and the company as well as the average wages of employees in the past, Efficiency standards are set by looking at the actual performance of a worker. The research method used in this research is descriptive with quantitative approach. The research data used in this study is secondary data. Data sources that do not directly provide data to data collectors, The difference in direct labor costs that occur in PT Masaiki is profitable. Although the difference in profitability in direct labor cost control is not necessarily an optimal profitable difference, but if the company uses standard costs with continuous / continuous analysis of differences in direct labor cost control then the direct labor costs that must be incurred by the company will be low and low costs will increase the profit so that optimal profit will be achieved by the company.
Model Kepuasan Orang Tua/Wali Siswa Berdasarkan Peningkatan Kualitas Pelayanan Sekolah Secara Berkelanjutan (Studi Kasus TK. Bina Mulia)
Authors: Khaerudin Muhamad , Srisulistiowati Dwi Budi , Setiawati Siti
Published: September 2021

kindergarten. Bina Mulia Cibitung is a school engaged in early childhood education Customer satisfaction survey is certainly needed to know the response of parents / guardians of students to the quality of service. But during this kindergarten. Bina Mulia has not conducted a survey on the satisfaction of parents of students to the services performed by teachers and administrative personnel. In anticipation of things that the school did not want during this pandemic, the survey was done not directly but online. Respondents to this survey are all parents / guardians of students both still active in school and who have graduated. This research is planned on an ongoing basis with the aim of knowing the level of satisfaction of parents / guardians to school services. In addition, this research aims to produce an online survey application that is integrated with the survey management information system, while the CSI method to measure customer satisfaction. Analysis of survey results is calculated using customer satisfaction index (CSI) method. CSI is a quantitative analysis in the form of a percentage of the number of parents / guardians of students to this service satisfaction survey.
Penerapan Soft Sistem Methodelogy Pada Pengembangan Sistem Informasi Akademik (Studi Kasus di SMKN 6 Kota Bekasi)
Authors: Hasan Ani Yoraeni , Henny Leidiyana
Published: September 2021

Academic information systems are important in teaching and learning activities, this is supported by adequate facilities and infrastructure. To support this, a system must be made that is able to assist in the teaching and learning process, namely by developing an academic information system. This development system uses the social system methodology method with the aim of helping the school's academic field achieve its goals and facilitate the teaching and learning process. This approach is designed using CATWOE analysis with components, namely customers, actors, the transformation process, world view, and the environment. The results of this study are able to answer the school's need for an effective and efficient system so that it can improve the performance of all school goals.
EVALUATION OF REMOVAL OF HEAVY METALS WITH PHYTOMASS ANNUAL HERBS WHEN USING VARIOUS FERTILIZER SYSTEMS
Authors: Ilinskiy A.
Published: September 2021

Under the conditions of a lysimetric experiment on podzolic chernozem, it was found that the use of dolomite flour contributed to a decrease in the mobility of metals and their translocation into crop products, which was reflected in a decrease in their removal relative to the background. The use of mineral fertilizers by increasing the yield of phytomass contributed to an increase in the removal of copper, zinc, lead and cadmium from the soil. The largest total removal of copper, zinc, lead and cadmium with the phytomass of annual grasses (8,035 mg/m2) is observed when using a mineral fertilizer system, and the smallest removal of the indicated metals is observed when using lime without manure (5,092 mg/m2).
National adverse event profile after lumbar spine surgery for lumbar degenerative disorders and comparison of complication rates between hospitals: a CSORN registry study
Authors: Ayling Oliver G. S. , Charest-Morin Raphaele , Eagles Matthew E. , Ailon Tamir , Street John T. , Dea Nicolas , McIntosh Greg , Christie Sean D. , Abraham Edward , Jacobs W. Bradley , Bailey Christopher S. , Johnson Michael G. , Attabib Najmedden , Jarzem Peter , Weber Michael , Paquet Jerome , Finkelstein Joel , Stratton Alexandra , Hall Hamilton , Manson Neil , Rampersaud Y. Raja , Thomas Kenneth , Fisher Charles G.
Published: September 2021

OBJECTIVE

Previous works investigating rates of adverse events (AEs) in spine surgery have been retrospective, with data collection from administrative databases, and often from single centers. To date, there have been no prospective reports capturing AEs in spine surgery on a national level, with comparison among centers.

METHODS

The Spine Adverse Events Severity system was used to define the incidence and severity of AEs after spine surgery by using data from the Canadian Spine Outcomes and Research Network (CSORN) prospective registry. Patient data were collected prospectively and during hospital admission for those undergoing elective spine surgery for degenerative conditions. The Spine Adverse Events Severity system defined minor and major AEs as grades 1–2 and 3–6, respectively.

RESULTS

There were 3533 patients enrolled in this cohort. There were 85 (2.4%) individual patients with at least one major AE and 680 (19.2%) individual patients with at least one minor AE. There were 25 individual patients with 28 major intraoperative AEs and 260 patients with 275 minor intraoperative AEs. Postoperatively there were 61 patients with a total of 80 major AEs. Of the 487 patients with minor AEs postoperatively there were 698 total AEs. The average enrollment was 321 patients (range 47–1237 patients) per site. The rate of major AEs was consistent among sites (mean 2.9% ± 2.4%, range 0%–9.1%). However, the rate of minor AEs varied widely among sites—from 7.9% to 42.5%, with a mean of 18.8% ± 9.7%. The rate of minor AEs varied depending on how they were reported, with surgeon reporting associated with the lowest rates (p < 0.01).

CONCLUSIONS

The rate of major AEs after lumbar spine surgery is consistent among different sites but the rate of minor AEs appears to vary substantially. The method by which AEs are reported impacts the rate of minor AEs. These data have implications for the detection and reporting of AEs and the design of strategies aimed at mitigating complications.
High-dose hypofractionated stereotactic body radiotherapy for spinal chordoma
Authors: Chen Xuguang , Lo Sheng-Fu L. , Bettegowda Chetan , Ryan Daniel M. , Gross John M. , Hu Chen , Kleinberg Lawrence , Sciubba Daniel M. , Redmond Kristin J.
Published: September 2021

OBJECTIVE

Spinal chordoma is locally aggressive and has a high rate of recurrence, even after en bloc resection. Conventionally fractionated adjuvant radiation leads to suboptimal tumor control, and data regarding hypofractionated regimens are limited. The authors hypothesized that neoadjuvant stereotactic body radiotherapy (SBRT) may overcome its intrinsic radioresistance, improve surgical margins, and allow preservation of critical structures during surgery. The purpose of this study is to review the feasibility and early outcomes of high-dose hypofractionated SBRT, with a focus on neoadjuvant SBRT.

METHODS

Electronic medical records of patients with spinal chordoma treated using image-guided SBRT between 2009 and 2019 at a single institution were retrospectively reviewed.

RESULTS

Twenty-eight patients with 30 discrete lesions (24 in the mobile spine) were included. The median follow-up duration was 20.8 months (range 2.3–126.3 months). The median SBRT dose was 40 Gy (range 15–50 Gy) in 5 fractions (range 1–5 fractions). Seventeen patients (74% of those with newly diagnosed lesions) received neoadjuvant SBRT, of whom 15 (88%) underwent planned en bloc resection, all with negative margins. Two patients (12%) developed surgical wound-related complications after neoadjuvant SBRT and surgery, and 4 (two grade 3 and two grade 2) experienced postoperative complications unrelated to the surgical site. Of the remaining patients with newly diagnosed lesions, 5 received adjuvant SBRT for positive or close surgical margins, and 1 received SBRT alone. Seven recurrent lesions were treated with SBRT alone, including 2 after failure of prior conventional radiation. The 2-year overall survival rate was 92% (95% confidence interval [CI] 71%–98%). Patients with newly diagnosed chordoma had longer median survival (not reached) than those with recurrent lesions (27.7 months, p = 0.006). The 2-year local control rate was 96% (95% CI 74%–99%). Among patients with radiotherapy-naïve lesions, no local recurrence was observed with a biologically effective dose ≥ 140 Gy, maximum dose of the planning target volume (PTV) ≥ 47 Gy, mean dose of the PTV ≥ 39 Gy, or minimum dose to 80% of the PTV ≥ 36 Gy (5-fraction equivalent doses). All acute toxicities from SBRT were grade 1–2, and no myelopathy was observed.

CONCLUSIONS

Neoadjuvant high-dose, hypofractionated SBRT for spinal chordoma is safe and does not increase surgical morbidities. Early outcomes at 2 years are promising, although long-term follow-up is pending.
Correlation of visual area with tremor improvement after MRgFUS thalamotomy in Parkinson’s disease
Authors: Xiong Yongqin , Han Dongshan , He Jianfeng , Zong Rui , Bian Xiangbing , Duan Caohui , Zhang Dekang , Zhou Xin , Pan Longsheng , Lou Xin
Published: September 2021

OBJECTIVE

MRI-guided focused ultrasound (MRgFUS) thalamotomy is a novel and minimally invasive alternative for medication-refractory tremor in Parkinson’s disease (PD). However, the impact of MRgFUS thalamotomy on spontaneous neuronal activity in PD remains unclear. The purpose of the current study was to evaluate the effects of MRgFUS thalamotomy on local fluctuations in neuronal activity as measured by the fractional amplitude of low-frequency fluctuations (fALFF) in patients with PD.

METHODS

Participants with PD undergoing MRgFUS thalamotomy were recruited. Tremor scores were assessed before and 3 and 12 months after treatment using the Clinical Rating Scale for Tremor. MRI data were collected before and 1 day, 1 week, 1 month, 3 months, and 12 months after thalamotomy. The fALFF was calculated. A whole-brain voxel-wise paired t-test was used to identify significant changes in fALFF at 12 months after treatment compared to baseline. Then fALFF in the regions with significant differences were extracted from fALFF maps of patients for further one-way repeated-measures ANOVA to investigate its dynamic alterations. The association between fALFF changes induced by thalamotomy and tremor improvement were evaluated using the nonparametric Spearman rank test.

RESULTS

Nine participants with PD (mean age ± SD 64.7 ± 6.1 years, 8 males) were evaluated. Voxel-based analysis showed that fALFF in the left occipital cortex (Brodmann area 17 [BA17]) significantly decreased at 12 months after thalamotomy compared to baseline (voxel p < 0.001, cluster p < 0.05 family-wise error [FWE] corrected). At baseline, fALFF in the left occipital BA17 in patients was elevated compared with that in 9 age- and gender-matched healthy subjects (p < 0.05). Longitudinal analysis displayed the dynamic changes of fALFF in this region (F (5,40) = 3.61, p = 0.009). There was a significant positive correlation between the falling trend in fALFF in the left occipital BA17 and hand tremor improvement after treatment over 3 time points (Spearman’s rho = 0.44, p = 0.02).

CONCLUSIONS

The present study investigated the impact of MRgFUS ventral intermediate nucleus thalamotomy on spontaneous neural activity in medication-refractory tremor-dominant PD. The visual area is, for the first time, reported as relevant to tremor improvement in PD after MRgFUS thalamotomy, suggesting a distant effect of MRgFUS thalamotomy and the involvement of specific visuomotor networks in tremor control in PD.
Early implementation of stereoelectroencephalography in children: a multiinstitutional case series
Authors: Lepard Jacob R. , Kim Irene , Arynchyna Anastasia , Lew Sean M. , Bollo Robert J. , O’Neill Brent R. , Perry M. Scott , Donahue David , Smyth Matthew D. , Blount Jeffrey
Published: September 2021

OBJECTIVE

Pediatric stereoelectroencephalography (SEEG) has been increasingly performed in the United States, with published literature being limited primarily to large single-center case series. The purpose of this study was to evaluate the experience of pediatric epilepsy centers, where the technique has been adopted in the last several years, via a multicenter case series studying patient demographics, outcomes, and complications.

METHODS

A retrospective cohort methodology was used based on the STROBE criteria. ANOVA was used to evaluate for significant differences between the means of continuous variables among centers. Dichotomous outcomes were assessed between centers using a univariate and multivariate logistic regression.

RESULTS

A total of 170 SEEG insertion procedures were included in the study from 6 different level 4 pediatric epilepsy centers. The mean patient age at time of SEEG insertion was 12.3 ± 4.7 years. There was no significant difference between the mean age at the time of SEEG insertion between centers (p = 0.3). The mean number of SEEG trajectories per patient was 11.3 ± 3.6, with significant variation between centers (p < 0.001). Epileptogenic loci were identified in 84.7% of cases (144/170). Patients in 140 cases (140/170, 82.4%) underwent a follow-up surgical intervention, with 47.1% (66/140) being seizure free at a mean follow-up of 30.6 months. An overall postoperative hemorrhage rate of 5.3% (9/170) was noted, with patients in 4 of these cases (4/170, 2.4%) experiencing a symptomatic hemorrhage and patients in 3 of these cases (3/170, 1.8%) requiring operative evacuation of the hemorrhage. There were no mortalities or long-term complications.

CONCLUSIONS

As the first multicenter case series in pediatric SEEG, this study has aided in establishing normative practice patterns in the application of a novel surgical technique, provided a framework for anticipated outcomes that is generalizable and useful for patient selection, and allowed for discussion of what is an acceptable complication rate relative to the experiences of multiple institutions.
International survey on the management of lumbosacral cutaneous stigmata in infants with suspected occult spinal dysraphism
Authors: Svokos Konstantina , Batista-Silverman Lígia , Graber Sarah J. , O’Neill Brent R. , Handler Michael H.
Published: September 2021

OBJECTIVE

Occult spinal dysraphism (OSD) is a common pediatric neurosurgical diagnosis rife with controversy surrounding both the screening of asymptomatic infants and the threshold to offer a prophylactic detethering operation. The authors sought to clarify international practice patterns with a survey of pediatric neurosurgeons.

METHODS

A survey asked pediatric neurosurgeons whether they would perform imaging in patients with a variety of cutaneous stigmata associated with OSD and whether they would offer prophylactic detethering surgery for asymptomatic patients with a variety of imaging findings on the OSD spectrum.

RESULTS

Completed surveys were received from 141 pediatric neurosurgeons. Broad consensus was demonstrated on the need for obtaining images in sample patients with more severe stigmata ranging from large lipoma with a skin appendage to focal dysplastic skin in the lumbar midline. Ninety percent of respondents would perform MRI for these patients. In contrast, for patients with a low-sacral dimple, flat hemangioma, and symmetric (Y-shaped) splaying of the intergluteal cleft, opinion on the need for imaging varied considerably (between 57% and 89% recommended imaging). Respondents differed on the type of imaging that they would perform, with 31% to 38% recommending ultrasound screening. The responses reflected less consensus on when to offer surgery to patients with simple spinal tethering (low-lying conus medullaris and fatty filum terminale). Both a lower level of the conus and increased thickness of the filum terminale affected decision-making.

CONCLUSIONS

The results of this survey showed significant consensus on the recommendation for screening imaging in patients with more dramatic cutaneous stigmata, although these stigmata are the rarest. A significant variance in opinions was reflected in the recommendation for imaging of the most common cutaneous stigmata. Consensus was also lacking on which lesions deserve prophylactic detethering surgery. Significant equipoise exists for future study of screening imaging and of surgical decision-making in patients with asymptomatic OSD and associated cutaneous stigmata.
Identifikasi Kepadatan Larva Nyamuk Aedes Sp Sebagai Vektor Penyakit Demam Berdarah Dengue di Kelurahan Mogolaing Kotamobagu
Authors: Hairil Akbar  , Hamzah B
Published: September 2021

Kasus demam berdarah dengue (DBD) di Indonesia pada tahun 2017 dilaporkan sebanyak 68,407 kasus dengan jumlah kasus meninggal sebanyak 493 orang dan IR 26,12. Provinsi Sulawesi Utara menempati urutan kedua yang memiliki CFR tinggi (1,55%) setelah Gorontalo (2,18%). Demam berdarah dengue (DBD) merupakan salah satu penyakit yang ditularkan oleh vektor nyamuk Aedes sp. Distribusi nyamuk Aedes sp dipengaruhi oleh perubahan lingkungan seperti ketinggian, suhu dan keadaan lingkungan. Masyarakat urban yang menggunakan tandon atau bejana sebagai tempat penampungan air yang tidak tertutup dapat meningkatkan populasi nyamuk Aedes sp menjadi tinggi. Jenis penelitian yang digunakan adalah penelitian yang bersifat deskriptif dengan jumlah sampel sebanyak 62 rumah yang ambil dengan teknik quota sampling. Data dikumpulkan menggunakan lembar observasi kemudian dianalisis secara deskriptif dan disajikan dalam bentuk tabel dan narasi. Hasil penelitian menunjukkan dari 115 rumah dan 516 yang diperiksa didapatkan 41 rumah dan 61 kontainer yang positif jentik Aedes sp dengan nilai House Index (HI) sebesar 35,65%, kemudian dari 516 kontainer yang diperiksa didapatkan 61 kontainer yang positif jentik Aedes sp dengan Container Index (CI) sebesar 11,82%, dan Bretau Index (BI) sebesar 53,04%. Hasil perhitungan House Index (HI) menunjukkan angka 35,65% dengan Desinty Figure (DF) adalah 5 yang menunjukkan kepadatan populasi larva di Kelurahan Mogolaing Kotamobagu masuk kedalam kategori sedang. Hal ini menunjukkan derajat penularan penyakit demam berdarah dengue (DBD) yang dibawa oleh vektor nyamuk Aedes sp adalah sedang sehingga perlu menjadi perhatian dan diwaspadai akan potensi kasus demam berdarah dengue (DBD) menjadi tinggi.
KEKERASAN TERHADAP PEREMPUAN: PEMICU DAN ALTERNATIF PENANGANAN
Authors: Muhammad Jadi
Published: September 2021

Artikel ini bertujuan untuk memberikan pemaparan tentang  kekerasan terhadap perempuan sebagai salah satu permasalahan yang sering dihadapi kaum perempuan. Melalui studi pustaka dari hasil penelitian dan pendapat para ahli yang berhubungan dengan topik kajian ini, beberapa hal seperti latar belakang, pengertian, termasuk kasus dan penanganan di Indonesia selama ini disajikan dalam artikel ini. Selain itu, alternatif solusi yang mungkin dilakukan untuk mencegah tindakan kekerasan terhadap perempuan juga didiskusikan, termasuk masukan tentang pentingnya penelitian lebih mendalam yang multisentris dan berkesinambungan mengenai topik permasalahan ini. Melalui cara ini, diharapkan akan dapat diperoleh gambaran yang lebih jelas demi terciptanya lingkungan yang lebih aman dan jauh dari tindak kekerasan bagi perempuan.
Colisão e ponderação de princípios fundamentais na inseminação artificial póstuma
Authors: Oliveira Álvares Laís Botelho , Gasparoni Gazolla de Siqueira Larissa
Published: September 2021

Considerando-se que as inovações tecnológicas desafiam a habilidade do legislador em acompanhar a evolução da sociedade, o presente artigo buscou avaliar a celeuma criada pela possibilidade de se proceder com a inseminação artificial após a morte, através dos pilares do Biodireito, do Direito Civil e dos Direitos Fundamentais. Para cumprir tal desiderato, foi utilizada a metodologia da ponderação de princípios, do nosso marco teórico, o jusfilósofo, Robert Alexy.
Judicialização da política, ativismo e discricionariedade judicial, com base na distinção entre regras, princípios e políticas públicas de Dworkin
Authors: Henrique Gaudêncio de Paula Fábio , Alem Mello Ferreira Rafael
Published: September 2021

Este artigo teve como objetivo fazer uma análise através da pesquisa bibliográfica do fenômeno da judicialização da política, ativismo e discricionariedade judicial, com base na distinção entre regras, princípios e políticas públicas, traçada por Dworkin. Em uma democracia estável nos dias atuais, o direito ocupa um papel central na organização da esfera institucional, ao definir as condições mínimas para o funcionamento do sistema político. Ao mesmo tempo, o reconhecimento de novos direitos pelo Constitucionalismo Contemporâneo ocasiona uma atuação mais destacada do Poder Judiciário, e essa situação, muitas vezes, é confundida pela entidade jurídica como uma justificativa para decisões sem qualquer critério de racionalidade, baseadas na mais pura discricionariedade judicial. Torna-se necessário, neste sentido, enfrentar os desafios que tem o Poder Judiciário a fim de contribuir para a concretização dos direitos fundamentais e da democracia. Afinal, concluímos que uma decisão constitucionalmente adequada também deve ser observada como um direito fundamental do cidadão. Pois os cidadãos, ao procurarem o Judiciário, uma vez que têm o direito de acesso à justiça, acreditam que suas causas serão contempladas e julgadas à luz do direito previamente estabelecido.
universidade corporativa do Grupo Berlim S.A.: uma análise de seus pontos fortes e dos aspectos que deveriam ser aprimorados
Authors: Faria Carnivali Manganelli Anna Clara , Vargas Ferreira Costa Débora , Paradela Victor Cláudio , Magalhães Kirchmair Débora
Published: September 2021

Nos últimos anos, os investimentos em educação corporativa ganharam espaço em diversas organizações, tendo em vista a importância da gestão do conhecimento para a manutenção da competitividade, em um ambiente de negócios cada vez mais desafiante. A partir dessa perspectiva, o artigo tem como objetivo analisar a Universidade Corporativa criada pelo grupo Berlim S.A (pseudônimo), à luz das teorias relacionadas à educação corporativa, buscando verificar em que aspectos ela já se consolidou e que melhorias poderiam ser buscadas. Foi desenvolvida uma pesquisa qualitativa, sendo os dados coletados nos documentos da instituição. A análise permitiu apurar que a educação corporativa e a universidade corporativa estão, na empresa estudada, articuladas com o planejamento estratégico, dando suporte ao crescimento da organização. Também foram apontados pontos de melhoria que devem ser objeto de atenção, em especial o maior investimento em ensino a distância e a inclusão de outros públicos nas ações de desenvolvimento promovidas.
Análise reflexiva da percepção de profissionais de publicidade sobre seu processo laboral
Authors: Schreiber Dusan , Bitencourt Valente Taís , Guerra Ashton Mary Sandra
Published: September 2021

O mercado de publicidade e propaganda representa um dos setores da indústria criativa, que se destaca pelo uso intensivo de inteligência e criatividade. O ambiente de acirrada competição entre os agentes econômicos materializa-se entre os colaboradores organizacionais, sob a forma de competição, pressão pelos resultados, controle de produtividade, tensionando as relações sociais. Com o intuito de contribuir para o tema em tela, foi realizada a pesquisa, com o delineamento metodológico de levantamento de campo, com seis profissionais de publicidade e propaganda, que trabalham em diversas organizações do setor, na cidade de Porto Alegre, visando evidenciar as características do processo de trabalho. A coleta de dados ocorreu por meio de entrevistas em profundidade, com perguntas que emergiram da revisão teórica, sendo divididas em três categorias de análise, a saber, (i) rotinas de trabalho; (ii) sentido do trabalho e (iii) trabalhador criativo no contexto atual de mercado. Os resultados da pesquisa evidenciaram a crescente precarização do ambiente de trabalho, pressão pelos resultados, jornadas de trabalho exaustivas e tempo exíguo para a produção de qualidade.
Körper in Phänomenologie und Bildungsphilosophie
Authors: Breil Patrizia
Published: September 2021

Wie wird an der Schnittstelle zwischen Philosophie, Philosophiedidaktik und allgemeiner Pädagogik über den menschlichen Körper gesprochen? Das Nachdenken über die körperliche Konstitution des Menschen wird in diesem Bereich dominiert von einem Leib-Begriff, der von Merleau-Pontys Phänomenologie der Wahrnehmung ausgeht. Unter diesem Fokus werden jedoch Entfremdungserfahrungen, die den eigenen Körper in seiner Materialität zum Gegenstand haben, kaum oder lediglich pathologisierend thematisiert. Das Buch stellt dem eine existentialistisch-phänomenologische Perspektive gegenüber, mit der bisher kaum erfasste Erfahrungen thematisiert werden können. Solche Erfahrungen sind die des eigenen, fremden Körpers in seiner materiellen Existenz – die Eingang finden sollen in philosophische Bildung.
Breast cancer screening literacy information on online platforms: A content analysis of YouTube videos
Authors: Brar Jasleen , Khalid Ayisha , Ferdous Mahzabin , Abedin Tasnima , Turin Tanvir C.
Published: September 2021

BACKGROUND: The YouTube platform has great potential of serving as a healthcare resource due to its easy accessibility, navigability and wide audience reach. Breast cancer screening is an important preventative measure that can reduce breast cancer mortality by 40%. Therefore, platforms being used as a healthcare resources, such as YouTube, can and should be used to advocate for essential preventative measures such as breast cancer screening. METHODS: In this study, the usefulness of videos related to breast cancer and breast cancer screening were analyzed. Videos were first screened for inclusion and then were categorized into very useful, moderately useful, somewhat useful, and not useful categories according to a 10-point criteria scale developed by medical professionals based on existing breast cancer screening guidelines. Two reviewers independently assessed each video using the scale. RESULTS: 200 videos were identified in the preliminary analysis (100 for the search phrase ‘breast cancer’ and 100 for the search phrase ‘breast cancer screening’). After exclusion of duplicates and non-relevant videos, 162 videos were included in the final analysis. We found the following distribution of videos: 4.3% very useful, 17.9% moderately useful, 39.5% somewhat useful, and 38.3% not useful videos. There was a significant association between each of the following and the video’s level of usefulness: video length, the number of likes, and the uploading source. Longer videos were very useful, somewhat useful videos were the most liked, personally produced videos were the most not useful, and advertisements produced the highest ratio of very useful to not useful videos. CONCLUSION: It is necessary to create more reliable and useful healthcare resources for the general population as well as to monitor health information on easily accessible social platforms such as YouTube.