bluuebunny/crossref_metadata_2025 huggingface dataset:
Tissue Factor and Factor VIIa as Therapeutic Targets in Disorders of Hemostasis
Authors: Hedner Ulla , Ezban Mirella
Published: September 2007

For hemophilia patients with inhibitors against FVIII or FIX, the development of recombinant factor VIIa (rFVIIa) raises the possibility of a therapeutic alternative whose availability and convenience of treatment are comparable to those of FVIII or FIX. In support of this new concept for the treatment of bleeding episodes, pharmacological doses of FVIIa have been shown to induce hemostasis. Pharmacological doses of rFVIIa enhance thrombin generation on thrombin-activated platelets, thereby facilitating the formation of strong, well-structured fibrin plugs resistant to premature proteolysis. Modified rFVIIa molecules with a stronger hemostatic potential have been produced. Inhibition of the FVII-TF-dependent pathway (TFPI and rFVIIai) has been tried in attempts to prevent thrombosis, with promising results in animal models so far not confirmed in clinical trials.
Childhood Obesity: Adrift in the “Limbic Triangle”
Authors: Mietus-Snyder Michele L. , Lustig Robert H.
Published: September 2007

The prevalence and severity of childhood obesity have increased steadily over the past three decades. The human species evolved to rigorously defend its lower limit for weight and adiposity but is tolerant of the upper limit, which, until recent times, was rarely approached. Neuroendocrine mechanisms within the limbic core of the brain prevent starvation (ventromedial hypothalamus), heighten reward (ventral tegmental area and nucleus accumbens), and attenuate stress (amygdala), in order to promote food-seeking and ingestive behavior and to conserve energy output. In a stressful modern environment with ready access to calorie-dense, highly palatable foods and limited venues for activity, normal, reflexive responsiveness to these three drives makes weight gain all but inevitable. The obesity that ensues often engenders insulin resistance, which undermines the ability of normal hunger and satiety signals to accurately modulate energy intake versus expenditure. Obesity interventions that rely on cognitive information alone cannot free children from this “limbic triangle.” Integrated multidisciplinary family- and community-based education, effective stress reduction, and a societal commitment to alter the food and built environments are all necessary components to battle the global obesity epidemic.
Apoptin: Therapeutic Potential of an Early Sensor of Carcinogenic Transformation
Authors: Backendorf Claude , Visser Astrid E. , de Boer A.G. , Zimmerman Rhyenne , Visser Mijke , Voskamp Patrick , Zhang Ying-Hui , Noteborn Mathieu
Published: September 2007

The avian virus-derived protein apoptin induces p53-independent apoptosis in a tumor-specific way. Apoptin acts as a multimeric complex and forms superstructures upon binding to DNA. In tumor cells, apoptin is phosphorylated and mainly nuclear, whereas in normal cells it is unphosphorylated, cytoplasmic, and becomes readily neutralized. Interestingly, apoptin phosphorylation, nuclear translocation, and apoptosis can transiently be induced in normal cells by cotransfecting SV40 large T oncogene, indicating that apoptin recognizes early stages of oncogenic transformation. In cancer cells, apoptin appears to recognize survival signals, which it is able to redirect into cell death impulses. Apoptin targets include DEDAF, Nur77, Nmi, Hippi, and the potential drug target APC1. Apoptin-transgenic mice and animal tumor models have revealed apoptin as a safe and efficient antitumor agent, resulting in significant tumor regression. Future antitumor therapies could use apoptin either as a therapeutic bullet or as an early sensor of druggable tumor-specific processes.
Polarized Calcium Signaling in Exocrine Gland Cells
Authors: Petersen Ole H. , Tepikin Alexei V.
Published: September 2007

Cytosolic Ca2+ signals are crucial for the control of fluid and enzyme secretion from exocrine glands. The highly polarized exocrine acinar cells have evolved sophisticated and complex Ca2+ signaling mechanisms that exercise precise control of the secretory events occurring across the apical plasma membrane bordering the gland lumen. Ca2+ stores in the endoplasmic reticulum, the secretory granules, the lysosomes, and the endosomes all play important roles in the generation of the local apical Ca2+ spikes that switch on Cl− channels in the apical plasma membrane as well as exocytotic export of enzymes. The mitochondria are crucial not only for ATP generation but also for the physiologically important subcellular compartmentalization of the cytosolic Ca2+ signals.
Structure and Function of the Polymeric Mucins in Airways Mucus
Authors: Thornton David J. , Rousseau Karine , McGuckin Michael A.
Published: September 2007

The airways mucus gel performs a critical function in defending the respiratory tract against pathogenic and environmental challenges. In normal physiology, the secreted mucins, in particular the polymeric mucins MUC5AC and MUC5B, provide the organizing framework of the airways mucus gel and are major contributors to its rheological properties. However, overproduction of mucins is an important factor in the morbidity and mortality of chronic airways disease (e.g., asthma, cystic fibrosis, and chronic obstructive pulmonary disease). The roles of these enormous, multifunctional, O-linked glycoproteins in health and disease are discussed.
Effects of automatic item eliminations based on item test analysis
Authors: Muntinga Jaap H. J. , Schuil Henk A.
Published: September 2007

Item test analysis is an aid to identify items that need to be eliminated from an assessment. An automatic elimination procedure based on item statistics, therefore, could help to increase the quality of a test in an objective manner. This was investigated by studying the effect of a standardized elimination procedure on the test results of a second-year course over a period of 6 successive years in 1,624 candidates. Cohort effects on the item elimination were examined by determining the number of additional items that had to be eliminated from three different tests in 3 successive academic years in two cohorts. The items that were part of more than one test and had to be eliminated according to the procedure in at least one of the tests appeared to have to be retained according to the same procedure in most of the other tests. The procedure harmed the high scoring students relatively more often than the other students, and the number of eliminated items appeared to be cohort dependent. As a consequence, automatic elimination procedures obscure the transparency of the grading process unacceptably and transform valid tests into inadequate samples of the course content.
Assessing core manipulative skills in a large, first-year laboratory
Authors: Moni Roger W. , Hryciw Deanne H. , Poronnik Philip , Lluka Lesley J. , Moni Karen B.
Published: September 2007

Responding to the concern from our faculty that undergraduate students do not have robust laboratory skills, we designed and implemented a strategy to individually teach and assess the manipulative skills of students in first-year laboratories. Five core laboratory skills were selected for the course entitled Human Biology, a large, first-year class of students, most of whom were enrolled in Bachelor of Pharmacy and Human Movement Studies. Here, we report details for the 365 students enrolled primarily in Pharmacy and Human Movement Studies bachelor degree programs in semester 1 of 2006. We designed a specific strategy to assess five core laboratory skills: 1) accurate and precise use of a micropipette, 2) calculation of dilutions and preparation of diluted samples of saline, 3) accurate representation of data using a graph, 4) use of a light microscope, and 5) acquisition of digital data by measuring the latent period for the Achilles reflex. Graduate tutors were trained to teach and assess each student on each skill. The development of competency was tracked for all students across all five skills. Most students demonstrated proficiency on their first attempt. The development of proficiency across the core skills depended on both the skill and degree program. In semester 2 of 2006, 854 students mostly enrolled in the Bachelor of Science degree program and were similarly taught and assessed on the same five core skills. This approach was an effective teaching and assessment strategy that, when applied beyond first year, should increase the level of laboratory skills across undergraduate programs in physiology.
Use of unsupervised online quizzes as formative assessment in a medical physiology course: effects of incentives on student participation and performance
Authors: Kibble Jonathan
Published: September 2007

Online quizzes were introduced into a large Medical Physiology class to provide students with formative assessment before midterm and final summative examinations. Use of unsupervised online quizzes was chosen to provide a flexible supplementary learning tool for students without overwhelming a small faculty. Several quiz models were applied, which varied in the availability of course credit points for participation and performance. The aims of the study were to investigate if participation in formative assessment was associated with improved course outcomes, if offering incentives for completing quizzes affected student participation, and if quiz performance was predictive of summative examination outcomes. Results showed that students who elected to use online quizzes performed better in summative examinations. Offering course credit of between 0.5% and 2% per quiz increased student participation. However, evidence was found for widespread inappropriate use of unsupervised online quizzes when incentives for participation were applied. Predictive validity of online quizzes could be demonstrated when comparing the first of several quiz attempts with subsequent summative examination scores.
“Challenge” Questions to Enhance Laboratory Experience and Student Skills: an Example
Authors: Dean Rob L.
Published: September 2007

As educators, we are continually designing new methods and procedures to enhance learning. During this process, good ideas are frequently generated and tested, but the extent of such activities may not be adequate for a full manuscript. Nonetheless, the ideas may be quite beneficial in improving the teaching and learning of physiology. Illuminations is a column designed to facilitate the sharing of these ideas (illuminations). The format of the submissions is quite simple: a succinct description of about one or two double-spaced pages (less title and authorship) of something you have used for the classroom, teaching, laboratory, conference room, etc. You may include one or two simple figures or references. Submit ideas for inclusion in Illuminations directly to the Associate Editor in charge, Stephen DiCarlo ( sdicarlo@med.wayne.edu ).
The positive impact of team-based virtual microscopy on student learning in physiology and histology
Authors: Goldberg Harry R. , Dintzis Renee
Published: September 2007

Team-based virtual microscopy and on-line learning were used to transform the first-year Physiology/Histology course at The Johns Hopkins School of Medicine into a student-centered learning environment. Prior to each laboratory session, students were required to view prelaboratory virtual lectures and examine digital slides that had been enhanced with annotations and 2-min microlectures. The laboratory classroom was then used for team-based learning exercises including student presentations and small-group discussions designed to integrate histology and physiology. The results of quantitative assessments indicated an 8- to 14-point increase over the identical final exams given over the past 5 yr. Means (±SD) of percent correct answers on the final exam were found to be 75.2% (11.1%), 72.5% (12.6%), 70.5% (12.6%), 73.6% (11.3%), 73.1% (12.2%), and 84.1% (9.1%) for years 2001–2006, respectively. The mean test scores for all other years were statistically lower compared with 2006, as determined by the Bonferroni post hoc multiple-comparison test ( P < 0.001 for all years).
Adenine nucleotides decrease the apparentKmof endogenous natriuretic peptide receptors for GTP
Authors: Antos Laura K. , Potter Lincoln R.
Published: September 2007

Natriuretic peptide receptors A (NPR-A) and B (NPR-B) mediate most effects of natriuretic peptides by synthesizing cGMP. ATP increases the activity of these receptors by an unknown mechanism. We recently reported that a nonhydrolyzable form of ATP, adenylyl imidodiphosphate (AMPPNP), stabilizes but is not required for the activation of NPR-A and NPR-B in membranes from highly overexpressing cells. Here, we repeated these studies on receptors expressed in endogenous settings. Kinetic analysis indicated that both AMPPNP and ATP dramatically decrease the apparent Kmof both receptors for GTP but had little effect on the Vmax. The EC50for AMPPNP decreased as substrate concentration increased whereas the magnitude of the effect was greater at lower GTP concentrations. ATP increased the activity of a mutant receptor containing glutamates substituted for all known phosphorylation sites similarly to the wild-type receptor, consistent with a phosphorylation independent mechanism. Finally, the putative ATP binding sites were investigated. Mutation of the ATP modulatory domain region had no effect, but mutation of K535A dramatically diminished ANP-dependent cyclase activity in a manner that was unresponsive to ATP. Mutation of the highly conserved 630-KSS to AAA (all alanines) resulted in an expressed receptor that had no detectable guanylyl cyclase activity. We conclude that ATP is not required for the initial activation of NPRs but does increase activity over time by reducing the apparent Kmfor GTP.
Hepatic transcriptome response to glucocorticoid receptor activation in rainbow trout
Authors: Aluru Neelakanteswar , Vijayan Mathilakath M.
Published: September 2007

Cortisol, the principal corticosteroid in teleosts, is thought to play a key role in the metabolic adjustments critical for regaining homeostasis. However, the target tissue molecular mechanisms involved in this adaptive response to corticosteroid stimulation are still unclear. Cortisol signaling is mediated predominantly by the glucocorticoid receptor (GR), and previous studies have shown that RU486 (a GR antagonist) offsets corticosteroid signaling in teleosts. To elucidate the molecular basis of GR-mediated metabolic readjustments, we exposed primary culture of trout hepatocytes in vitro to cortisol (to mimic stressed levels seen in fish), RU486, or a combination of both for 24 h. The gene expression was analyzed using a low-density custom-made rainbow trout cDNA array enriched with endocrine-, metabolic-, and stress-related genes. The microarray results for select genes were further validated using quantitative real-time PCR. Cortisol treatment significantly increased glucose production in hepatocytes, and this response was blocked by RU486, confirming GR-mediated corticosteroid signaling. Cortisol also elevated GR transcript levels, and this response was abolished by RU486, whereas both cortisol and RU486, either alone or in combination, reduced GR protein content in trout hepatocytes. Cortisol treatment significantly modulated the expression of several genes known to be involved in intermediary metabolism, cellular stress response, reproduction, and xenobiotic metabolism. Most of these cortisol-mediated transcript changes were abolished in the presence of RU486, suggesting a key role for GR-specific signaling in this adaptive response. Taken together, our results suggest a key role for genomic cortisol signaling in the liver molecular reprogramming that is critical for coping with stress in fish.
Proinflammatory and Oxidative Stress Markers in Patients with Periodontal Disease
Authors: Borges Jr. Ivan , Moreira Emília Addison Machado , Filho Danilo Wilhem , de Oliveira Tiago Bittencourt , da Silva Marcelo Barreto Spirelle , Fröde Tânia Silvia
Published: September 2007

Objective. To evaluate the involvement of proinflammatory and oxidative stress markers in gingival tissue in individuals with chronic periodontitis.Subject and methods. Eighteen subjects were divided in two groups: experimental (age52.9±5.0) and control (age51.1±9.6). The activities of enzymatic antioxidants such as catalase, glutathione peroxidase (GPx), glutathione S-transferase (GST), glutathione reductase, nonenzymatic antioxidants: total glutathione and reduced glutathione, oxidized glutathione (GSSG), thiobarbituric acid reactive substances (TBARS), and myeloperoxidase activity (MPO) were evaluated in gingival tissues from interproximal sites. Statistical differences between groups were determined by independent Studentttest andP<.05.Results. Individuals with periodontal disease exhibited a significant increase in the activities of MPO, GPx, GST, and also in TBARS and GSSG levels in gingival tissue compared to the control group (P<.05).Conclusion. The results of the present work showed an important correlation between oxidative stress biomarkers and periodontal disease.
Influence of Dietary Fat and Zinc Supplementation on the Iron Utilization in Growing Rats
Authors: Boesch-Saadatmandi Christine , Most Erika , Weigand Edgar
Published: September 2007

Background/Aims: There is increasing evidence that the amount and type of dietary fat may modify the utilization of the trace element iron. The present study investigated the effect of high amounts of fat of different origin at marginal and high dietary zinc supply on the iron utilization. Methods: Growing male rats, assigned to 1 of 6 groups of 8 animals each were fed diets that contained either 7 or 100 µg zinc/g. These diets were enriched with 0 or 22% fat as beef tallow (BT) or as sunflower oil (SO) above the basal level of 3% soybean oil. Iron was added as ferrous sulfate at 60 µg/g of diet. Results: The apparent iron absorption was markedly lower in the case of the high-fat diets at either zinc level. The BT diets resulted in significantly higher iron concentrations in the liver compared to both the SO and control diets. Hemoglobin and hematocrit were not influenced by any of the treatments. Conclusion: Although the high-fat diets reduced iron absorption, there was no evidence for lower iron status parameters in blood and tissues. In contrast, BT as a source of saturated fatty acids markedly elevated liver iron concentrations.
Nonsteroidal Anti-Inflammatory Drugs and the Risk of Parkinson Disease
Authors: Bornebroek Marjolijn , de Lau Lonneke M.L. , Haag Mendel D.M. , Koudstaal Peter J. , Hofman Albert , Stricker Bruno H.C. , Breteler Monique M.B.
Published: September 2007

Background: Several lines of evidence suggest a role of inflammatory processes in Parkinson disease, although it is still unclear whether inflammation is a cause or rather a consequence of neurodegeneration. Methods: In a prospective population-based cohort study among 6,512 participants aged ≧55 years, with repeated in-person examination, we evaluated the association between cumulative use of nonsteroidal anti-inflammatory drugs (NSAIDs) and the risk of Parkinson disease. Complete information on filled prescriptions was available from automated pharmacy records. Data were analyzed by means of Cox proportional hazards regression analysis, adjusted for age, sex, smoking habits and coffee consumption. Results: After an average 9.4 years of follow-up, 88 new cases of Parkinson disease were detected. No association was found between use of NSAIDs and the risk of Parkinson disease (adjusted hazard ratio for any NSAID use, 1.50; 95% confidence interval, 0.95–2.37). Conclusion: Our findings do not support the hypothesis that NSAIDs might decrease the risk of Parkinson disease.
Plasma Titers of Antibodies against Epstein-Barr Virus BZLF1 and Risk of Multiple Sclerosis
Authors: Massa J. , Munger K.L. , O’Reilly E.J. , Falk K.I. , Ascherio A.
Published: September 2007

Background/Aims: Results of recently conducted prospective studies have demonstrated that the presence of high titers of anti-EBNA-1 or anti-EBNA complex IgG antibodies in healthy individuals is a strong risk factor for multiple sclerosis (MS). Antibodies to BZLF1, the product of the homonymous early lytic gene, have been found to be related to risk of nasopharyngeal carcinoma, but have not been previously measured in MS studies. Methods: We examined whether high levels of anti-BZLF1 IgG antibodies also predict MS risk in a nested case-control study among women in the Nurses Health Study and Nurses Health Study II cohorts. Results: Results of this prospective study suggest that antibody titers to EBNAs are the strongest predictor of MS risk. Conclusion: Little further contribution may be provided by measuring anti-BZLF1 antibodies in regard to MS risk.
The Relationship between the Adhesion Characteristics of Acrylic Intraocular Lens Materials and Posterior Capsule Opacification
Authors: Katayama Yasuhiro , Kobayakawa Shinichiro , Yanagawa Hideo , Tochikubo Tetsuo
Published: September 2007

Purpose: To investigate the relationship between the adhesion characteristics of similarly designed hydrophobic acrylic intraocular lenses (IOLs) and posterior capsule opacification (PCO). Methods: Three similarly shaped hydrophobic acrylic IOLs with a sharp-edged optic were used. Adhesive force of IOLs was measured with a tackiness tester. Human lens epithelial cells (LECs) were grown on each IOL for 48 h. LECs were then stained with crystal violet, which served as an index of the amount of cells attached to IOLs. Cellular migration and proliferation assays were performed using chamber inserts containing a collagen membrane. After 96 h of incubation, the collagen membranes were stained with hematoxylin and eosin for analysis. Three similarly shaped IOLs were implanted in rabbits. The eyes were enucleated 3 weeks later and analyzed for PCO area. Results: Hydrophobic acrylic IOLs were classified into three groups: A (less adhesive), B (moderately) and C (highly). The migration area of LECs on the collagen membrane was 5.65 ± 4.5% in group A, 2.83 ± 2.1% in group B, and 1.41 ± 1.5% in group C, with a significant difference between groups A and C (p < 0.05). The mean percentage area of PCO in the rabbit eye was 19.4 ± 16.7% in group A, 17.5 ± 8.5% in group B, and 5.5 ± 3.8% in group C, with a significant difference between groups A and C (p < 0.05). Conclusion: Adhesive force of hydrophobic acrylic IOLs may play an important role in preventing PCO. Among the similarly shaped hydrophobic acrylic IOLs, IOLs of highly adhesive material inhibited LEC migration and PCO more than IOLs of less adhesive material.
Meditation-Induced Psychosis
Authors: Kuijpers H.J.H , van der Heijden F.M.M.A. , Tuinier S. , Verhoeven W.M.A.
Published: September 2007

Background:Meditation is a self-regulatory psychological strategy that is frequently applied in Western as well as non-Western countries for different purposes; little is known about adverse events. Sampling and Methods: A male patient is described who developed an acute and transient psychosis with polymorphic symptomatology after meditating. A literature search for psychotic states related to meditation was carried out on PubMed, Embase and PsycInfo. Results: In the case presented a diagnosis of acute polymorphic psychotic disorder was made. Other case reports dealt with either a relapse of a pre-existent psychotic disorder or with a brief psychotic reaction in patients without a psychiatric history. Conclusion:Meditation can act as a stressor in vulnerable patients who may develop a transient psychosis with polymorphic symptomatology. The syndrome is not culture bound but sometimes classified in culture-bound taxonomies like Qi-gong Psychotic Reaction.
Matrix Metalloproteinase-2 Promoter Polymorphism Is Associated with Breast Cancer in a Mexican Population
Authors: Delgado-Enciso Iván , Cepeda-Lopez Friedman R. , Monrroy-Guizar Elisa A. , Bautista-Lam Jose R. , Andrade-Soto Maricela , Jonguitud-Olguin Gregorio , Rodriguez-Hernandez Alejandrina , Anaya-Ventura Aristoteles , Baltazar-Rodriguez Luz M. , Orozco-Ruiz Martha , Soriano-Hernandez Alejandro D. , Rodriguez-Sanchez Iram P. , Lugo-Trampe Angel , Espinoza-Gomez Francisco , Michel-Peregrina Martha L.
Published: September 2007

Background:Matrix metalloproteinase-2 (MMP-2) is an enzyme with proteolytic activity on matrix proteins, particularly basement membrane constituents. A single nucleotide polymorphism C>T transition at –1306 displayed a strong association with several cancers. Our study investigated whether or not the MMP-2 –1306C>T polymorphism contributed to the development of breast cancer (BC) in a Mexican population. Methods: 90 patients with BC and 96 control subjects were analyzed to detect MMP-2 –1306C>T polymorphism. Results: The frequency of MMP-2 CC genotype was significantly higher in BC patients when compared with the control group (OR 2.15; 95% CI 1.1–4.1). MMP-2 CC genotype frequency was more pronounced in younger subjects (≤50 years) at diagnosis (OR 2.66; 95% CI 1.04–6.96). Conclusion: The data suggest that MMP-2 –1306C>T polymorphism strongly contributes to the development of BC in the population studied, especially among women 50 years old and younger.
Sexual Dysfunction in Peritoneal Dialysis Patients
Authors: Lai Chun-Fu , Wang Yu-Ting , Hung Kuan-Yu , Peng Yu-Sen , Lien Yih-Ron , Wu Ming-Shiou , Chang Chung-Hsin , Chiang Shou-Shang , Yang Chwei-Shiun , Shiah Ching-Jyh , Lu Chia-Sheng , Yang Chih-Ching , Chuang Hsueh-Fang , Wu Kwan-Dun , Tsai Tun-Jun , Chen Wang-Yu
Published: September 2007

Background/Aims: Sexual dysfunction in patients undergoing peritoneal dialysis (PD) is highly prevalent, but studies addressing this issue are scarce. This cross-sectional study aims to evaluate sexual dysfunction and the determinants among PD patients. Methods: All chronic PD patients in 8 PD centers were asked to complete a self-reported questionnaire – the International Index of Erectile Function (IIEF) for men and the Index of Female Sexual Function (IFSF) for women – so that sexual function could be assessed. They also answered the Beck Depression Inventory (BDI) to measure depressive symptoms. Results: Among 294 patients invited for study, 54 men (mean age 48.8 ± 10.8 years) and 45 women (mean age 43.6 ± 7.4 years) were willing to and completed the sexual function questionnaires. The median IIEF score in the men was 56.25. The prevalence of erectile dysfunction, identified by the score in erectile domain of IIEF ≤25, was 51.9%. Older age and higher fasting glucose levels were independently associated with a decreased IIEF score. In women, IFSF score (with a median 27) was significant lower than in healthy peri- or postmenopausal control women. Factors of higher BDI score, receiving automated PD, and older age independently associated with a decreased IFSF score. Conclusions: Sexual dysfunction is clinically relevant and multi-dimensional among PD patients. Gender differences exist in the attributing factors of sexual functioning. These warrant more awareness and investigation in the global health care of dialysis patients.
Effects of Rosuvastatin on Glomerular Capillary Size-Selectivity Function in Rats with Renal Mass Ablation
Authors: Corna Daniela , Sangalli Fabio , Cattaneo Dario , Carrara Fabiola , Gaspari Flavio , Remuzzi Andrea , Zoja Carla , Benigni Ariela , Perico Norberto , Remuzzi Giuseppe
Published: September 2007

Background: Evidence is accumulating that statins can reduce proteinuria and disease progression in chronic kidney disease. However, some safety concerns have been recently raised on the use of these agents, mainly due to transient episodes of proteinuria observed in patients receiving high doses of rosuvastatin. Methods: We investigated in rats with renal mass ablation (RMR) whether rosuvastatin (5 or 20 mg/day) worsens proteinuria as compared to untreated RMR animals. Moreover, we also examined whether rosuvastatin-induced changes in proteinuria would be due to the effect of the drug on permselective properties of glomerular capillary barrier, measured by the fractional clearance of graded-size Ficoll molecules and/or by proximal tubular mechanisms, by assessing urinary excretion of β2-microglobulin. Results: RMR rats given rosuvastatin for 28 days showed a progressive increase in proteinuria, with values numerically but not significantly higher than those in RMR animals given the vehicle. In RMR rats, rosuvastatin did not significantly affect the fractional clearance of Ficoll as compared to vehicle-treated RMR animals. A significant correlation was found between urinary protein and β2-microglobulin excretion in rats treated with rosuvastatin (r = 0.936, p < 0.001), but not in those given vehicle. Renal function, glomerular and tubulointerstitial injury were comparable in rosuvastatin-treated and untreated RMR rats at the end of the 28-day follow-up. Conclusion: In rats with RMR, rosuvastatin mildly enhances urinary protein excretion rate. This, however, was not the result of further changes in the size-permselective function of glomerular capillary barrier.
MDR1 Single Nucleotide Polymorphisms Predict Response to Vinorelbine-Based Chemotherapy in Patients with Non-Small Cell Lung Cancer
Authors: Pan Ji-hong , Han Jin-xiang , Wu Jian-mei , Sheng Li-jun , Huang Hai-nan , Yu Qing-zhong
Published: September 2007

Background: The polymorphisms of genes participate in metabolism and transport, and therefore may have an impact on the response to vinorelbine. Objectives: To investigate whether genotypes of CYP3A5, MDR1 and cyclooxygenase-2 (COX-2) are associated with the response to vinorelbine in non-small cell lung cancers (NSCLC). Methods: We determined the genotypes of CYP3A5(*3), MDR1 (2677G→T at exon 21 and 3435C→T at exon 26 and their haplotypes) and COX-2 (–1195G→A) polymorphisms by PCR-RFLP and chemotherapy response in 69 Chinese Han patients with NSCLC who received a combination chemotherapy of vinorelbine-cisplatin (VC). The χ2 test was used to investigate potential associations between genotypes and response to chemotherapy. Odds ratios and 95% confidence intervals were calculated. Results: The 3435 CC genotype was associated with a significantly better chemotherapy response compared with the combined 3435 CT and TT genotypes (p = 0.025). The 2677 GG genotype was also associated with a better chemotherapy response compared with the combined 2677 GT and TT genotype, although it was not statistically significant. Moreover, we analyzed the haplotypes of MDR1 3435-2677: patients harboring the 2677G-3435C haplotype had a statistically significantly better response to chemotherapy compared with those with the other haplotypes combined (p = 0.015). CYP3A5*3 is not likely to correlate with sensitivity to vinorelbine in NSCLC. COX-2 (–1195G) is likely to result in a better response to vinorelbine (nonsignificant). Conclusions: Our findings suggest that MDR1 2677G→T/A and 3435C→T polymorphisms can be used to predict treatment response to VC chemotherapy in NSCLC patients.
High Blood Pressure Trends in Children and Adolescents in National Surveys, 1963 to 2002
Authors: Din-Dzietham Rebecca , Liu Yong , Bielo Marie-Vero , Shamsa Falah
Published: September 2007

Background—

Secular trend data on hypertension in children and adolescents are scarce and inconsistent. In the face of growing obesity, we sought to assess high blood pressure (HBP) secular trends in children and adolescents enrolled in national surveys and to determine whether the HBP trend reversed its course with the rise in obesity.

Methods and Results—

National survey data obtained from multistage probability sampling of the US noninstitutionalized population from 1963 to 2002 were examined; 8- to 17-year-old non-Hispanic blacks and whites and Mexican Americans were included. HBP ascertainment was based on age-, gender-, and height percentile–specific systolic and diastolic BPs. Weighted analyses were performed to account for the complex design. The BP, pre-HBP, and HBP trends were downward from 1963 to 1988 and upward thereafter. Pre-HBP and HBP increased 2.3% (
P
=0.0003) and 1% (
P
=0.17), respectively, between 1988 and 1999. Obesity increase, more so abdominal than general obesity, partially explained the rise in HBP and pre-HBP from 1988 to 1999. BP and HBP reversed their downward trends 10 years after the increase in the prevalence of obesity. Additionally, an ethnic and gender gap appeared in 1988 for pre-HBP and in 1999 for HBP; non-Hispanic blacks and Mexican Americans had a greater prevalence of HBP and pre-HBP than non-Hispanic whites, and males had a greater prevalence than females.

Conclusions—

HBP and pre-HBP in children and adolescents are on the rise. These new findings have implications for the cardiovascular disease public health burden, particularly the risk of a new cardiovascular disease transition. They reinforce the urgent call for early prevention of obesity and HBP and illustrate racial/ethnic disparities in this age group.
Blood Pressure Control in Hispanics in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial
Authors: Margolis Karen L. , Piller Linda B. , Ford Charles E. , Henriquez Mario A. , Cushman William C. , Einhorn Paula T. , Colon Pedro J. , Vidt Donald G. , Christian Rudell , Wong Nathan D. , Wright Jackson T. , Goff David C.
Published: September 2007

Historically, blood pressure control in Hispanics has been considerably less than that of non-Hispanic whites and blacks. We compared determinants of blood pressure control among Hispanic white, Hispanic black, non-Hispanic white, and non-Hispanic black participants (N=32 642) during follow-up in a randomized, practice-based, active-controlled trial. Hispanic blacks and whites represented 3% and 16% of the cohort, respectively; 33% were non-Hispanic black and 48% were non-Hispanic white. Hispanics were less likely to be controlled (<140/90 mm Hg) at enrollment, but within 6 to 12 months of follow-up, Hispanics had a greater proportion <140/90 mm Hg compared with non-Hispanics. At 4 years of follow-up, blood pressure was controlled in 72% of Hispanic whites, 69% of Hispanic blacks, 67% of non-Hispanic whites, and 59% of non-Hispanic blacks. Compared with non-Hispanic whites, Hispanic whites had a 20% greater odds of achieving BP control by 2 years of follow-up (odds ratio: 1.20; 95% CI: 1.10 to 1.31) after controlling for demographic variables and comorbidities, Hispanic blacks had a similar odds of achieving BP control (odds ratio: 1.04; 95% CI: 0.86 to 1.25), and non-Hispanic blacks had a 27% lower odds (odds ratio: 0.73; 95% CI: 0.69 to 0.78). We conclude that in all patients high levels of blood pressure control can be achieved with commonly available medications and that Hispanic ethnicity is not associated with inferior control in the setting of a clinical trial in which hypertensive patients had equal access to medical care, and medication was provided at no cost.
Chronic Baroreceptor Activation Enhances Survival in Dogs With Pacing-Induced Heart Failure
Authors: Zucker Irving H. , Hackley Johnnie F. , Cornish Kurtis G. , Hiser Bradley A. , Anderson Nicholas R. , Kieval Robert , Irwin Eric D. , Serdar David J. , Peuler Jacob D. , Rossing Martin A.
Published: September 2007

Much of the current pharmacological therapy for chronic heart failure targets neurohormonal activation. In spite of recent advances in drug therapy, the mortality rate for chronic heart failure remains high. Activation of the carotid baroreceptor (BR) reduces sympathetic outflow and augments vagal tone. We investigated the effect of chronic activation of the carotid BR on hemodynamic and neurohormonal parameters and on mortality in dogs with chronic heart failure. Fifteen dogs were instrumented to record hemodynamics. Electrodes were applied around the carotid sinuses to allow for activation of the BR. After 2 weeks of pacing (250 bpm), electrical carotid BR activation was initiated in 7 dogs and continued for the remainder of the study. The start of BR activation was used as a time reference point for the remaining 8 control dogs that did not receive BR activation. Survival was significantly greater for dogs undergoing carotid BR activation compared with control dogs (68.1±7.4 versus 37.3±3.2 days, respectively;
P
<0.01), although arterial pressure, resting heart rate, and left ventricular pressure were not different over time in BR-activated versus control dogs. Plasma norepinephrine was lower in dogs receiving BR activation therapy 31 days after the start of BR activation (401.9±151.5 versus 1121.9±389.1 pg/mL in dogs not receiving activation therapy;
P
<0.05). Plasma angiotensin II increased less in dogs receiving activation therapy (plasma angiotensin II increased by 157.4±58.6 pg/mL in control dogs versus 10.1±14.0 pg/mL in dogs receiving activation therapy;
P
<0.02). We conclude that chronic activation of the carotid BR improves survival and suppresses neurohormonal activation in chronic heart failure.
Boys Named Sue: Disruptive Children and Their Peers
Authors: Figlio David N.
Published: September 2007

This article proposes an unusual identification strategy to estimate the effects of disruptive students on peer behavior and academic outcomes. Because boys with names most commonly given to girls may be more prone to misbehavior as they get older, they may become differentially disruptive in school. In elementary school there is no relationship between names and boys' behavior, but on transition to middle school, a large gap emerges in behavior between boys with names associated with girls and other boys. Using boys' names as an instrumental variable, I utilize data on names, classroom assignment, behavior problems, and student test scores from a large Florida school district in the school years spanning 1996–97 through 1999–2000 to directly measure the effects of classroom disruption on peer performance. I find that behavior problems are associated with increased peer disciplinary problems and reduced peer test scores, indicating that disruptive behavior of students has negative ramifications for their peers.
Regional Characterization of Pasture Changes through Time and Space in Rondônia, Brazil
Authors: Numata Izaya , Roberts Dar A. , Sawada Yoshito , Chadwick Oliver A. , Schimel Joshua P. , Soares João V.
Published: September 2007

Although pasture degradation has been a regional concern in Amazonian ecosystems, our ability to characterize and monitor pasture degradation under different environmental and human-related conditions is still limited. Regional analysis of pasture dynamic patterns was conducted using high-frequency temporal satellite data and ancillary data to better understand pasture degradation under varied soil, environmental, and pasture management conditions in the state of Rondônia, Brazil. The 10-day normalized difference vegetation index (NDVI) composite derived from Moderate Resolution Imaging Spectroradiometer (MODIS) 250-m resolution was used to characterize different grass phenological patterns for 32 counties in Rondônia between 2001 and 2003. Six pasture greenness classes showed that high greenness pasture classes dominated in young pastures, while low greenness pasture classes were least common. As pastures aged, the proportion of high greenness pasture classes decreased and the proportion of low greenness pastures increased, indicating a decrease in forage productivity over time in Rondônia. The magnitude of productivity decline depended on environmental constraints and land use systems. To refine this analysis, trajectories of pasture change were determined using spectral mixture analysis applied to Landsat time series data from 1988 to 2001 with the focus on two counties that show contrasting patterns of potential of grass production: Pimenteira, representing the “degraded” pasture category, and Governador Jorge Teixeira, as the “productive” pasture category. The results revealed a clear pasture degradation pattern in Pimenteira, related to low soil fertility and dry climate conditions, while Governador Jorge Teixeira, with better soil fertility and intermediate precipitation, did not show signs of pasture degradation through time.
A Displacement-Based Error Measure Applied in a Regional Ensemble Forecasting System
Authors: Keil Christian , Craig George C.
Published: September 2007

Errors in regional forecasts often take the form of phase errors, where a forecasted weather system is displaced in space or time. For such errors, a direct measure of the displacement is likely to be more valuable than traditional measures. A novel forecast quality measure is proposed that is based on a comparison of observed and forecast satellite imagery from the Meteosat-7 geostationary satellite. The measure combines the magnitude of a displacement vector calculated with a pyramid matching algorithm and the local squared difference of observed and morphed forecast brightness temperature fields. Following the description of the method and its application for a simplified case, the measure is applied to regional ensemble forecasts for an episode of prefrontal summertime convection in Bavaria. It is shown that this new method provides a plausible measure of forecast error, which is consistent with a subjective ranking of ensemble members for a sample forecast. The measure is then applied to hourly images over a 36-h forecast period and compared with the bias and equitable threat score. The two conventional measures fail to provide any systematic distinction between different ensemble members, while the new measure identifies ensemble members of differing skill levels with a strong degree of temporal consistency. Using the displacement-based error measure, individual ensemble members are found to compare better with observations than either a short-term deterministic forecast or the ensemble mean throughout the convective period.
Serious Mental Illness and Arrest
Authors: Swartz James A. , Lurigio Arthur J.
Published: September 2007

Past studies of the mediating effects of substance use on the criminal justice involvement of the mentally ill have tended to focus on a single disorder, schizophrenia, and on violent crimes. This study examined the generality of the relationships among psychiatric disorders, substance use, and arrests for violent, nonviolent, and drug-related offenses using data collected for the 2001 and 2002 National Survey on Drug Use and Health. Logistic regression models showed that for violent offenses, the statistical association between serious mental illness (SMI) and arrest across psychiatric diagnoses was substantially but only partially mediated by substance use. For nonviolent offenses and for drug-related offenses, the relationship between SMI and arrest was almost completely mediated by substance use and reduced to statistical nonsignificance. These findings suggest that co-occurring substance use increases the chances a person with any SMI, not just schizophrenia, will be arrested for any offense, not just violent offenses, but that the magnitude of this relationship varies by offense type and, to a lesser extent, by disorder.
Strain, Attribution, and Traffic Delinquency Among Young Drivers
Authors: Ellwanger Steven J.
Published: September 2007

This article enhances our knowledge of general strain theory (GST) by applying it to the context of traffic delinquency. It does so by first describing and confirming the development of a social–psychological measure allowing for a test of GST. Structural regression analysis is subsequently employed to test the theory within this context across a range of delinquent driving behaviors. Tests indicate that strain experienced while operating a motor vehicle consists of distinct contexts that when considered separately both enhance our understanding of GST and spell policy implications for state-directed interventions. Implications for future GST testing, measurement, and application are also discussed.
Recidivism of Supermax Prisoners in Washington State
Authors: Lovell David , Johnson L. Clark , Cain Kevin C.
Published: September 2007

This study of recidivism among Washington supermax prisoners used a retrospective matched control design, matching supermax prisoners one-to-one with nonsupermax prisoners on mental illness status and up to eight recidivism predictors. Supermax prisoners committed new felonies at a higher rate than nonsupermax controls, but the difference was not statistically significant. Prisoners released directly from supermax to the community, however, showed significantly higher felony recidivism rates than their nonsupermax controls and committed new offenses sooner than supermax prisoners who left supermax 3 months or more before prison release. Limitations, methodological issues, and policy implications are considered.
The Implications of Implementing a `Flexible' Syllabus for ESL Policy in the Sultanate of Oman
Authors: Al-Issa Ali S.M.
Published: September 2007

The education system in general and ELT in particular are rigidly controlled in the Sultanate of Oman, which gives teachers little room to supplement the mandated textbook. This article, hence, discusses ideologies about the `flexible' ELT syllabus and the role of the teacher's professionalism in the syllabus implementation process.

One of the powerful `ideologies' that govern ELT in the Sultanate of Oman is thus the `neocolonial/communicative'. Another powerful ideology is the `professional', which is exclusively concerned with the teacher's professionalism. These two ideologies complement each other and are present in the various statements made by different agents involved in the Omani ELT system, the pertinent literature and the Philosophy and Guidelines for the Omani English Language School Curriculum (Nunan et al. 1987), herewith referred to as the National English Language Policy/ Plan (NELP). However, these seem to conflict with the `colonialist/culturalist' ideologies incorporated in the content of the materials produced locally by the Ministry of Education— Our World through English (OWTE) and its suggested means of implementation. This is considered to negatively impact `Omanization'.

This research paper, therefore, critically examines and discusses this state of ideological conflict via triangulating data from semi-structured interviews conducted with different agents involved in the implementation of ELT in Oman, pertinent literature and policy texts and NELP. Such examination and discussion have their implications for second language policy implementation.
Challenges in Curriculum Development
Authors: Alsagoff Lubna , Low Ee-Ling
Published: September 2007

The Postgraduate Diploma in English Language Teaching (PGDELT) programme at the National Institute of Education (NIE), Singapore provides an interesting case study of how economic and entrepreneurial concerns and aspirations in modern university settings have played a role alongside pedagogical motivations in shaping the development of the curriculum of English Language Teaching (ELT) teacher education programmes. In this article, we trace the development of the PGDELT which began as a programme to train the classroom practitioner to one that aspires to also develop the transformative intellectual. While this evolution has clearly been motivated by sociocultural and pedagogical concerns viz. changing teacher education paradigms and national educational initiatives, economic developments such as China's rapid economic progress and the expanding role of English as a global language in the region have also provided a significant impetus.
The Legitimacy of the People
Authors: Näsström Sofia
Published: September 2007

In political theory it goes without saying that the constitution of government raises a claim for legitimacy. With the constitution of the people, however, it is different. It is often dismissed as a historical question. The conviction is that since the people cannot decide on its own composition the boundaries of democracy must be determined by other factors, such as the contingent forces of history. This article critically assesses this view. It argues that like the constitution of government, the constitution of the people raises a claim for legitimacy. The failure to see this is what makes many theorists run into the arms of history. They submit the legitimacy of the people to the arbitrary and asymmetrical forces of the present.