bluuebunny/crossref_metadata_2025 huggingface dataset:
DEVELOPMENT AND PROPERTIES OF NEUTRALIZING MONOCLONAL ANTIBODIES FOR FUSION PROTEIN OF RESPIRATORY SYNCYTIAL VIRUS
Authors: Kushch A. A. , Klimova R. R. , Fedorova N. E. , Masalova O. V. , Niconova A. A. , Lesnova E. I. , Momotyuk E. D. , Demidova N. A. , Samartseva T. G. , Zverev V. V.
Published: April 2020

Introduction. Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract infections in infants and the elderly. The absence of a wide range of therapeutic drugs and vaccines indicates to the high relevance of the development of new effective drugs for the prevention and treatment of RSV infections. Purpose: to obtain highly active and specific monoclonal antibodies (MAbs) capable of detecting RSV in infected cells and neutralizing the infectious activity of the virus in vitro. Material and methods. RSV reference strains of group A 2 subgroups (A2 and Long) were propagated in HEp-2 and MA-104 cell lines, respectively. Mice were immunized with purified RSV A2 virus. MAbs were obtained using hybridoma technology. Results. A panel of 6 MAbs reacting with RSV strains А2 and Long has been obtained. Four MAbs were IgG (IgG2a or IgG2b subtype), two MAbs were IgM. All MAbs reacted with RSV F-protein in immunochemical tests. The MAbs actively reacted with RSV in ELISA, in immufluorescence and peroxidase staining of infected cells, and in immunodot test. Five out of 6 MAbs neutralized of RSV in cell culture. Different properties of MAbs suggest that they target different antigenic sites of F-protein. Discussion. Comparative analysis suggests that the obtained MAbs can be used for the development of diagnostic preparations, for RSV detection in clinical materials and confirmation of infection etiology by rapid culture method. Conclusion. High activity and specificity of MAbs indicate that they can serve as a basis for development vaccines and preventive medicines.
ANTIVIRAL EFFECT OF «KAGOCEL» SUBSTANCE IN VITRO ON INFLUENZA VIRUSES H1N1, H1N1PDM09 AND H3N2
Authors: Fediakina I. T. , Konopleva M. V. , Proshina E. S. , Linnik E. V. , Nikitina N. I.
Published: April 2020

Introduction. Active circulation of pandemic influenza and new variants of influenza H3N2 strains requires monitoring of antiviral efficacy of drugs permitted for influenza therapy in the Russian Federation. Purpose. Assessment of antiviral efficacy of «Kagocel» substance against influenza viruses H1N1, H1N1pdm09 and H3N2 in vitro. Material and methods. Cytotoxic effect of «Kagocel» substance on MDCK cells had been determined by stained with MTS. Antiviral efficacy of «Kagocel» substance against influenza infection has been studied in vitro in the culture of MDCK cells infected with influenza virus strains: A/Puerto Rico/8/34 (H1N1), А/California/7/2009 (H1N1)pdm09, А/Hong Kong/1/68 (H3N2) and А/Hong Kong/4801/2014 (H3N2). The antiviral activity of «Kagocel» substance was tested by its effect on the infectious titer of the influenza viruses and on its impact on the expression level of viral antigens in the enzyme immunoassay test system. Results. «Kagocel» substance had low toxicity for MDCK cells. «Kagocel» inhibited the infection titer of influenza virus strains A/Puerto Rico/8/34 (H1N1), А/California/7/2009 (H1N1)pdm09, А/Hong Kong/1/68 (H3N2) and А/ Hong Kong /4801/2014 (H3N2) in the MDCK cell culture with equal efficacy. Study of the impact of «Kagocel» substance on the expression level of viral antigens by ELISA also revealed its antiviral efficacy for all tested strains. Dose dependence was observed from concentration of substance and from infective dose of virus. Discussion. Effective suppression of the reproduction of influenza virus strains A(H1N1), A(Н1N1)pdm09 and A(H3N2) in the different sublines of MDCK cells with «Kagocel» was shown by the different methods. These results give the possibility to suggest that along with the ability to induce interferons, «Kagocel» can impact on the reproduction of influenza virus, but the further research is needed. Conclusion. «Kagocel» substance effectively inhibits the reproduction of influenza virus strains A(H1N1), A(Н1N1)pdm09 and A(H3N2) in vitro. At the same time, the selectivity index is quite high.
Low-Cost Automotive Capacitive Discharge Ignition (CDI) Coil for Low Frequency Ozone Generator
Authors: Sani Muhammad Ikhsan
Published: April 2020

This paper presents an alternative solution for generating ozone using a low-cost automotive Capacitive Discharge Ignition (CDI) coil. High voltage ozone generating theory is implemented using a capacitive discharge circuit that uses ignition coil as its high voltage step-up transformer. A computer simulation has been performed to confirm the validity of the circuit function. By calculation and measurement, the coil has 196,71 voltage amplification factor. Furthermore, it has been implemented at a low frequency of about 10 - 40 Hz. Meanwhile, ozone output is measured using the colorimetric method. From a series of tests, that coil implementation has successfully generated a high voltage on ozone reactor tube at 31.47 kV voltages that essential for ozone production. Change of frequency will change the ozone concentration output linearly. The test was conducted using three different frequency: 10 Hz, 20 Hz, and 40 Hz. The result has shown that the highest ozone yield was 80 mg/hour.
Real-Time Object Detection For Wayang Punakawan Identification Using Deep Learning
Authors: Thohari Afandi Nur Aziz , Adhitama Rifki
Published: April 2020

Indonesia is a country that has a variety of cultures, one of which is wayang kulit. This typical javanese performance art must continue to be preserved so that to be known by future generations. There are many wayang figures in Indonesia, and the most famous is punakawan. Wayang punakawan consists of four character namely semar, gareng petruk, and bagong. To preserve wayang punakawan to be known by the next generation, then in this study created a system that is able to identify real-time punakawan object using deep learning technology. The method that used is Single Shot Multiple Detector (SSD) as one of the models of deep learning that has a good ability in classifying data with three-dimensional structures such as real-time video. SSD model with MobileNet layer can work in slight computation, so that it can be run in real-time system. To classify object there are two steps that must be done such as training process and testing process. Training process takes 28 hours with 100.000 steps of iteration.The result of training process is a model which used to identify object. Based on the test result obtained an accuracy to detect object was 98,86%. This prove that the system has been able to optimize object in real-time accurately.
Informing Computer Vision with Optical Illusions
Authors: Nematzadeh Nasim , Powers David Martin Ward , Lewis Trent
Published: April 2020

Illusions are fascinating and immediately catch people's attention and interest, but they are also valuable in terms of giving us insights into human cognition and perception. A good theory of human perception should be able to explain the illusion, and a correct theory will actually give quantifiable results. We investigate here the efficiency of a computational filtering model utilised for modelling the lateral inhibition of retinal ganglion cells and their responses to a range of Geometric Illusions using isotropic Differences of Gaussian filters. This study explores the way in which illusions have been explained and shows how a simple standard model of vision based on classical receptive fields can predict the existence of these illusions as well as the degree of effect across multiple scales. A fundamental contribution of this work is to highlight the fact that it may be too early and hastly to reject isotropic filters altogether in favour of orientation selective ones for explaining mid/high level visual phenomena. Therefore the intention here is to link bottom-up processes to higher level perception and cognition consistent with Marr's theory of vision and edge map representation.
Chemical synthesis of SmAlO3 by stearic acid route: structure, morphology and microwave dielectric properties
Authors: Li J.M. , Zhang Chuimin , Liu Hui , Qiu Tai , Fan Chuangang
Published: April 2020

A rapid and facile approach was developed for the synthesis of ultrafine SmAlO3 powders through spontaneously combusting stearic acid precursors. The obtained products were characterized by typical techniques including X-ray diffraction (XRD), Fourier Transform Infrared (FT-IR), thermogravimetric and differential thermal analysis (TG-DTA), scanning electron microscopy (SEM) and electron microscopy transmission (TEM) to analyze the phase composition and microstructure. The dielectric characteristics of SmAlO3 microwave ceramics using the as-obtained products as original materials were also studied. Comparing with conventional solid-state reaction method, the synthesis temperature was dramatically reduced to 750 °C. Large size sheet structure was composed of a number of micro/nano-scale crystallites that were almost irregular in shape due to the mutual growth and overlapped shape of adjacent grains. The SmAlO3 ceramics with high density and uniform microstructure were obtained after sintering at 1500 °C for 4 h due to good sintering activity of the as-synthesized powders. In addition, desired dielectric properties at microwave frequencies (dielectric constant εr = 20.22, quality factor Q·f = 74110 GHz, and temperature coefficient of resonant frequency TCf = -74.6 ppm/°C) were achieved.
Potential risk factors for the reactivation of the replication of hepatitis B viruses after transcatheter arterial chemoembolization of hepatocellular carcinoma: a retrospective analysis
Authors: Wang Xiaoguang , Yang Xiaodan , Yu Haitao , Song Zhengwei , Chen Fei , Fei Jianguo
Published: April 2020

Objective: To investigate the clinical features of hepatitis B virus(HBV) reactivation after transcatheter arteriaI chemoembolization (TACE) treatment in patients with hepatocellular carcinoma (HCC), and analyze the relationship between hepatitis B virus reactivation and clinicopathological factors and prognosis. Methods: Clinical data of 108 patients with HCC treated by TACE from January 2006 to January 2014 were retrospectively studied. The relationship between the clinical data and HBV reactivation were analyzed and the differences in survival rates between the reactivation group and the non-reactivation group were also compared. Results: 42 (38.9%) patients developed HBV reactivation. The reactivation rate in patients with HBV DNA ≥ 104 was 65.8% (25/38), and was much higher than that of the patients with HBV DNA < 104 (24.3%, 17/70). The cellular immune function of reactivation group was significantly lower than that of non-reactivation group(P < 0.01). There was a significant difference (P=0.03) in 2-year survival rate between the activated and non-activated groups, and their survival rates were 35.9% and 53.3%, respectively. Conclusion: Some patients with primary hepatocellular carcinoma may have hepatitis B virus reactivation after receiving TACE treatment, and positive HBV DNA, immunosuppression were the risk factors for the development of HBV reactivation. Patients with hepatitis B virus reactivation after TACE have poor prognosis. The study suggests that antiviral therapy and immunoenhancer were necessary to improve curative effect and survival rate in HCC patients who underwent TACE.
Exogenous Sucrose Supply Regulates the Non-Structural Carbohydrate, Endogenous Hormone and Mineral Element Levels before the Flower Blooming and Fruit Abscission Stages in the Biodiesel Tree Sapindus mukorossi Gaertn.
Authors: Gao Yuan , Yang Ying , Gao Shilun , Jia Liming , Liu Shiqi , Weng Xuehuang
Published: April 2020

Background: Nutrient deficiency leads to a high fruit abscission rate in Sapindus mukorossi Gaertn. (Soapberry), which is one of the most widely cultivated biodiesel feedstock forests in China. Exogenous sucrose can provide a solution to nutrient deficiency and fruit abscission, which was applied to whole trees at two stages, 20 days before blooming (DBB stage) and fruit abscission (DBFA stage). Six sucrose concentrations, 0%, 1%, 1.5%, 3%, 5% and 7%, were sprayed three times at a completely randomized block design with 5 replications and 6 treatments. 13CO2 labelling experiments were carried out after the 3 sprayings. Results: (1) In the DBB stage, the 3% treatment significantly increased the inflorescence fructose and glucose contents 1-1.2 times, also resulted in the highest fruit GA3, leaf IAA, fruit IAA and fruit ZT contents, while it decreased the inflorescence ABA from 16 μg/g to 4 μg/g. (2) The 1.5% and 3% treatments significantly increased the carbohydrate content and decreased fruit ABA content to 30%-50% of the control level in the DBFA stage. (3) High-concentration sugar treatment (over 3%) increased the nitrogen, phosphorus, and potassium contents, which decreased the calcium and magnesium contents. (4) The 13C-dispatching ability of the inflorescence was 3 times greater than leaves under high-concentration sugar treatment in the DBB stage. Supplying 1.5% sucrose nearly doubled the allocation capacity in the DBFA stage. (5) The source-sink nutrient migration pathway showed that leaf and fruit sugars were directly correlated via phosphorus. Fruit fructose and glucose contents affected the leaf mineral element contents. Conclusions: It can conclude that exogenous application of 3% sucrose in the DBB stage and 1.5% sucrose in the DBFA stage can increase the sink nutrition allocation capacity, and phosphorus is the main mineral element correlated with leaf and fruit sugars.
A survey of knowledge of prevention of venous thromboembolism in patients undergoing major orthopedic surgery
Authors: Xu Yaping , Zhao Hongyu , Fan Meng , Zhao Tingting
Published: April 2020

Background: Patients undergoing major orthopedic surgery are at an extremely high risk of developing venous thromboembolism, which deserves adequate attention. However, few studies have focused on knowledge of prevention of venous thromboembolism. The study had three objectives: (1) to investigate knowledge of prevention of venous thromboembolism in patients undergoing major orthopedic surgery, (2) to analyze its influential factors, and (3) to provide evidence for interventions.Methods: The convenience sampling method was adopted to select 464 patients who underwent major orthopedic surgery in a third-level first-class hospital in Beijing. A self-designed questionnaire was administered to these patients to investigate their knowledge of prevention of venous thromboembolism.Results: Of the 464 respondents, 32.1% had good knowledge of prevention of venous thromboembolism, and 30.8% had poor knowledge of it. In total, 40.1% of the participants had a clear understanding of the risk factors for venous thromboembolism, and 31% had a poor understanding. The clinical manifestations of venous thromboembolism were well understood by 29.3% participants and poorly understood by 40.9% participants. In total, 13.8% participants had knowledge of preventive measures for venous thromboembolism, and 31.2% had poor knowledge of such preventive measures. Living condition, knowledge of venous thromboembolism before hospitalization, and receiving knowledge of prevention of venous thromboembolism during hospitalization were important factors affecting the knowledge of prevention of venous thromboembolism in patients undergoing major orthopedic surgery.Conclusions: The knowledge level of prevention of venous thromboembolism in patients undergoing major orthopedic surgery is poor, and medical personnel should pay full attention to this issue and disseminate knowledge of prevention of venous thromboembolism during hospitalization to improve patients’ knowledge of this condition.
Effectiveness of Gastric Bypass Versus Gastric Sleeve for Cardiovascular Disease: Protocol and Baseline Results for a Comparative Effectiveness Study
Authors: Coleman Karen J , Fischer Heidi , Arterburn David E , Barthold Douglas , Barton Lee J , Basu Anirban , Courcoulas Anita , Crawford Cecelia L , Fedorka Peter , Kim Benjamin , Mun Edward , Murali Sameer , Reynolds Kristi , Suh Kangho , Wei Rong , Yoon Tae K , Zane Robert
Published: April 2020

Background

When compared with conventional weight loss strategies, bariatric surgery results in substantially greater durable weight loss and rates of disease remission.

Objective

The ENGAGE CVD (Effectiveness of Gastric Bypass versus Gastric Sleeve for Cardiovascular Disease) cohort study aimed to provide population-based, comprehensive, rigorous evidence for clinical and policy decision making regarding the choice between gastric bypass and gastric sleeve for overall cardiovascular disease (CVD) risk reduction, risk factor remission, and safety.

Methods

The cohort had 22,095 weight loss surgery patients from a large integrated health care system in Southern California assembled from 2009 to 2016 who were followed up through 2018. Bariatric surgery patients were followed up for the length of their membership in the health care system. Of the patients who had at least five years of follow-up (surgery between 2009 and 2013), 85.86% (13,774/16,043) could contribute to the outcome analyses for the ENGAGE CVD cohort.

Results

Patients in the ENGAGE CVD cohort were 44.6 (SD 11.4) years old, mostly women (17,718/22,095; 80.19%), with 18.94% (4185/22,095) non-Hispanic black and 41.80% (9235/22,095) Hispanic, and had an average BMI of 44.3 (SD 6.9) kg/m2 at the time of surgery. When compared with patients who did not contribute data to the 5-year outcome analysis for the ENGAGE CVD cohort (2269/16,043; 14.14%), patients who contributed data (13,774/16,043; 85.86%) were older (P=.002), more likely to be women (P=.02), more likely to be non-Hispanic white (P<.001), more likely to have had an emergency department visit in the year before surgery (P=.006), less likely to have a mental illness before surgery (P<.001), and more likely to have had a CVD event at any time before surgery (P<.001).

Conclusions

This study had one of the largest populations of gastric sleeve patients (n=13,459). The 5-year follow-up for those patients who had surgery between 2009 and 2013 was excellent for a retrospective cohort study at 85.86% (13,774/16,043). Unlike almost any study in the literature, the majority of the ENGAGE CVD cohort was racial and ethnic minority, providing a rare opportunity to study the effects of bariatric surgery for different racial and ethnic groups, some of whom have the highest rates of severe obesity in the United States. Finally, it also used state-of-the-art statistical and econometric comparative effectiveness methods to mimic the effect of random assignment and control for sources of confounding inherent in large observational studies.

International Registered Report Identifier (IRRID)

RR1-10.2196/14936
Tracking COVID-19 in Europe: Infodemiology Approach
Authors: Mavragani Amaryllis
Published: April 2020

Background

Infodemiology (ie, information epidemiology) uses web-based data to inform public health and policy. Infodemiology metrics have been widely and successfully used to assess and forecast epidemics and outbreaks.

Objective

In light of the recent coronavirus disease (COVID-19) pandemic that started in Wuhan, China in 2019, online search traffic data from Google are used to track the spread of the new coronavirus disease in Europe.

Methods

Time series from Google Trends from January to March 2020 on the Topic (Virus) of “Coronavirus” were retrieved and correlated with official data on COVID-19 cases and deaths worldwide and in the European countries that have been affected the most: Italy (at national and regional level), Spain, France, Germany, and the United Kingdom.

Results

Statistically significant correlations are observed between online interest and COVID-19 cases and deaths. Furthermore, a critical point, after which the Pearson correlation coefficient starts declining (even if it is still statistically significant) was identified, indicating that this method is most efficient in regions or countries that have not yet peaked in COVID-19 cases.

Conclusions

In the past, infodemiology metrics in general and data from Google Trends in particular have been shown to be useful in tracking and forecasting outbreaks, epidemics, and pandemics as, for example, in the cases of the Middle East respiratory syndrome, Ebola, measles, and Zika. With the COVID-19 pandemic still in the beginning stages, it is essential to explore and combine new methods of disease surveillance to assist with the preparedness of health care systems at the regional level.
The Resistance of Local Pigmented Rice Varieties against Bacterial Leaf Blight
Authors: Joko Tri , Kristamtini Kristamtini , Sumarno Sumarno , Andriyanto Rofiq
Published: April 2020

Bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv. oryzae (Xoo) is an important disease in rice plants worldwide, including in Indonesia. The use of resistant variety against BLB is the best effort in disease control because it is considered as the most effective and environmentally friendly. This study aimed to evaluate the resistance of local varieties, red rice (cv. Sembada Merah) and black rice (cv. Sembada Hitam), against Xoo compared to white rice variety (Ciherang), commonly cultivated by the farmers. The study was conducted in a greenhouse and arranged in Factorial of Completely Randomized Design (CRD) with 5 replications and 2 treatment factors: variety (Sembada Hitam, Sembada Merah, and Ciherang) and inoculation (with and without inoculated by Xoo bacterial suspension). Xoo inoculation was performed by clipping the leaves that close to the reproductive phase when the heading begins to be produced. The disease intensity and Area Under Disease Progress Curve (AUDPC) over two weeks were used to determine the level of resistance of the tested plant varieties. The results showed that black rice and red rice had better levels of resistance against BLB compared to white rice. At two weeks after inoculation, Sembada Hitam had the lowest AUDPC value followed by Sembada Merah, while the Ciherang had the highest AUDPC value and was categorized as a susceptible variety to Xoo.
Antifungal Potency of Secondary Metabolites Produced by Endophytic Bacteria against Pathogenic Fungi Pyricularia oryzae Cav.
Authors: Widiantini Fitri , Qadryani Mia Rahmah , Hartati Fuji , Yulia Endah
Published: April 2020

Blast disease caused by Pyricularia oryzae Cav. is one of the most important diseases on rice. One of the alternative controlling methods in P. oryzae is biological control through the utilization of secondary metabolites produced by endophytic bacteria. The study aimed to determine the antifungal potency of secondary metabolites produced by rice endophytic bacteria against P. oryzae. The experiment was conducted using 9 endophytic bacteria isolated rice (Os1, Os2, Os3, Os4, Os5, Os6, Os7, Os8, and Os10). Each isolates were grown in ISP2 liquid media and the secondary metabolites compounds were extracted using two different solvents; methanol and ethyl acetate : methanol (4:1) (v/v). The effect of secondary metabolites was tested using agar well diffusion method. The results demonstrated that the secondary metabolites extracted by both solvents have antifungal effect on the growth of P. oryzae. The highest growth inhibition was shown by secondary metabolites extracted by ethyl acetate : methanol (4:1) from Os1 (42%) and Os3 (39%). Antifungal activity of the secondary metabolites was indicated by the formation of clear zone. HPLC (High Performance Liquid Chromatography) analysis showed the differences of peaks and retention time between secondary metabolites produced by Os1 and Os3 which has antifungal activity and secondary metabolites produced by Os10 that did not show the antifungal activity.
APRENDIZAGEM SIGNIFICATIVA DE MATEMÁTICA EM UM CURSO SUPERIOR DE ENGENHARIA UTILIZANDO O GEOGEBRA
Authors: Ziccardi Lydia Rossana Nocchi , Fusco Cristiana Abud da Silva
Published: April 2020

No presente artigo apresentamos um estudo de caso, no âmbito de uma disciplina de matemática que é oferecida num curso superior de Engenharia. Relatamos uma aula realizada num laboratório de informática para aprofundar alguns conceitos relativos a Geometria Analítica e Cálculo Vetorial, utilizando o software de matemática dinâmica GeoGebra. Tal atividade teve como objetivos verificar como os alunos reagiriam frente a uma nova estratégia de aula, diferente da estratégia usual e, além disso, se tal intervenção tornaria a aprendizagem do conteúdo abordado mais significativa. Realizamos um estudo teórico sobre a aprendizagem significativa de Ausubel (1968) e ampliamos a discussão apresentando duas estratégias de ensino consideradas por Ponte (2005): o ensino direto e o ensino-aprendizagem exploratório. Concluímos que a utilização do recurso tecnológico favoreceu a aprendizagem significativa.
Sequência didática interdisciplinar usando o software Modellus para determinação da qualidade de vida de uma população
Authors: De Almeida Chrystian Bastos
Published: April 2020

RESUMOEste artigo visa a apresentação de uma sequência didática para alunos do Ensino Médio que contempla competências e habilidades das áreas de Matemática e Geografia. Com ela, o pesquisador pode estimar a qualidade de vida da população do seu município para alguns anos depois, usando modelagem matemática. Estuda-se o conceito de função, variável dependente e independente e percebe-se que esses conceitos também estão presentes em conteúdos estudados em Geografia, como PIB, PIB per capita, IDH, etc. Com isso, faz-se o levantamento de dados desses indicadores para o município nos últimos anos e, usando a modelagem, faz-se a projeção para anos seguintes. Para tanto, fizemos uso do software matemático Modellus como instrumento auxiliar nas atividades de modelação.
Editorial
Authors: Igliori Sonia Barbosa Camargo
Published: April 2020

Este é o Editorial do número 2 do volume 6 da Revista Ensino da Matemática em Debate, revista do Departamento de Matemática da PUC-SP, do ano de 2019. O número apresenta seis artigos científicos.
O ENSINO DE RAZÃO E PROPORÇÃO POR MEIO DE ATIVIDADES
Authors: Cabral Natanael Freitas , Dias Gustavo Nogueira , LOBATO JUNIOR JOSE MARIA DOS SANTOS
Published: April 2020

Este trabalho teve como objetivo analisar as potencialidades de uma sequência didática para o ensino de Razão e Proporção, diferente das práticas usuais, aplicada para alunos do 7º ano do Ensino Fundamental e orientada pela seguinte questão pesquisa: Quais as contribuições que uma sequência didática, estruturada nos moldes do Ensino por Atividades, podem trazer para minimizar as dificuldades no processo de Ensino/ Aprendizagem de Razão e Proporção? O referencial teórico adotado tem como metodologia de pesquisa a Engenharia Didática que se desdobra nas seguintes etapas: Análises prévia; Experimentação e Análise a posteriori e Validação. Para a elaboração das atividades nos fundamentamos no Ensino por Atividades, além dos pressupostos de uma sequência didática proposta por Cabral (2017) e, para a análise dos dados coletados, usamos a Análise Microgenética. A partir das informações obtidas das análises prévias, por meio de uma revisão de estudos, da opinião de 65 discentes egressos do 7º ano do Ensino Fundamental e da consulta a 65 docentes de matemática da Educação Básica, identificamos algumas dificuldades no processo de ensino-aprendizagem de razão e proporção e elaboramos uma sequência didática com vinte e duas atividades para abordar os conteúdos. A experimentação foi aplicada em uma Escola municipal pública do município de Barcarena – PA com 25 alunos do 7º ano do nível fundamental. A análise dos resultados se deu por meio de uma abordagem microgenética coletadas a partir das interações entre professor e alunos, além do desempenho dos discentes na resolução de 10 questões contempladas em um teste final. Ao final do experimento, afirmamos que a sequência didática aplicada proporciona resultados favoráveis à aprendizagem dos alunos, pois após as atividades aplicadas, obtiveram um desempenho satisfatório na resolução de questões sobre os conteúdos em estudo.
O USO E EXPLORAÇÃO DE DOIS APLICATIVOS DE CELULARES, COMICS PANEL E STRIPCREATOR: UMA EXPERIÊNCIA REALIZADA NO ENSINO DE MATEMÁTICA
Authors: Oliveira Terezinha Marisa Ribeiro de , Amaral Carmem Lúcia Costa
Published: April 2020

A Matemática é tratada pelos alunos como uma disciplina difícil e as aulas são descritas por eles como entediantes e desconectadas de outras disciplinas importantes como a de Língua Portuguesa. Diante disso, apresentamos uma experiência realizada com 90 alunos do 8º e 9º ano do Ensino Fundamental Anos Finais de uma escola pública da cidade de Votorantim (São Paulo), em que utilizamos dois aplicativos de celulares (Comics panel e Stripcreator), como recurso didático para tornar as aulas de Matemática mais interessantes. Nosso objetivo foi verificar o papel motivacional e pedagógico desses aplicativos como ferramenta metodológica no ensino da Matemática. Os conteúdos trabalhados foram radiciação, trigonometria, polinômios e semelhança de triângulos. Os alunos também utilizaram o aplicativo WhatsApp para esclarecimento de dúvidas entre eles, com a professora e para enviar os trabalhos para a professora. Os resultados evidenciaram que os aplicativos auxiliaram os alunos a se interessarem pela Matemática.
Lectio continua and biblical literacy within the Methodist Church
Authors: Mackenzie Ed
Published: April 2020

Lectio continua – preaching through a single biblical book – tends to be less prominent in British Methodism than following a lectionary or a thematic series. In a context of declining biblical literacy, however, lectio continua is a fruitful way of encouraging engagement with Scripture. Following a discussion of the challenges of biblical illiteracy, this article argues that lectio continua can promote biblical literacy through its focus on whole books of Scripture, its consideration of the context of biblical passages, and its invitation to close readings of biblical texts – all key skills for reading the Bible well. A case study demonstrates how such an approach could be applied to preaching through 1 John.
Theoretical Content of the Finance Category
Authors: Shvetsov Yu.G. , Kamnev I.M.
Published: April 2020

Subject. The article deals with the analysis of the contemporary status of the economic category Finance in Russia.
Objectives. The article seeks to disclose the internal content of the category in relation to the current level of development of the national economy.
Methods. For the study, we used the dialectic method of examining objective economic laws, patterns and phenomena in their constant development and interrelationships, and the systems approach, as well.
Results. We present our own concept of the economic category, the essential functions of finance, financial system of the State and its structural elements. We formulate the objectives and framework of financial policy and public financial management system at various levels, and propose a methodological approach to the study of financial management as an independent scientific discipline.
Conclusions. We conclude about the need for an equable approach to the theoretical aspect of the category Finance both in the economic theory and practice.
The region's natural and resource potential as a component of investment resources: The Ganja-Gazakh economic region of Azerbaijan case study
Authors: Gasanov A.A. , Khan-Khoyskaya I.V. , Bagirova A.M.
Published: April 2020

Subject. This article highlights the natural and resource potential and capabilities of the Ganja-Gazakh Economic Region of Azerbaijan.
Objectives. The article aims to assess the feasibility of developing projects to increase domestic and external investment in the Ganja-Gazakh Economic Region.
Methods. For the study, we used content, systems, and statistical data analyses, and the emergence principle, that implies the impossibility to reduce properties of the whole to the sum of properties of its parts.
Results. The article provides an assessment of the reserves of natural raw resources of the Ganja-Gazakh Economic Region.
Conclusions. The ecological environment of the region has been damaged by depletion and pollution as the consumption of natural resources increases. There is a need for increased investment in resource-use projects and priority programmes for the restoration and conservation of the environment. The local executive authorities should prepare decisions to encourage investment in the modernization of the region's production infrastructure.
Teachers’ Awareness on Implementation of the Regulation on Assessing Elementary School Students Under Circular 22
Authors: Khanh Nguyen Cong , Huong Do Thi , Ha Tran Thi
Published: April 2020

The paper presented the current situation of the level of elementary school teachers’ assessment on the implementation of the regulation of assessing primary school students according to Circular 22. The sample of the survey consisted of 813 teachers of some elementary schools in 6 provinces such as Lao Cai, Hanoi, Thua Thien Hue, Dak Lak, Tra Vinh and Ho Chi Minh City. The survey results showed that the majority of teachers have had a proper awareness of the purpose, principles, scientific bases and how to evaluate elementary school students according to the competency approach. At the same time, they also had very positive comments about the changes in behavior, their own perceptions and the implementation of orientation activities for students in the classroom towards developing capacity. However, a significant proportion of the surveyed teachers still had  incorrect perceptions and beliefs and so far, they faced a number of difficulties. The results obtained from the survey are considered as a very useful document for management as well as educators to review the strengths and limitations in the process of implementation to devise strategies and remedies in the near future.
Jurisdiction over claims made against public-legal institutions
Authors: Basmanov Nikolay , Ilin Andrei Vladimirovich
Published: April 2020

This article discusses the question of territorial jurisdiction over claims made against public-legal institutions (Russian Federation, constituent entities of the Russian Federation, municipal formations). The subject of this research is the current procedural norms regulating the questions of jurisdiction, and the established law enforcement practice. Attention is turned to the existence of gaps in legal regulation of the question of jurisdiction over claims made against public-legal institutions in the Civil Procedure Code of the Russian Federation and Arbitration Procedure Code of the Russian Federation. The authors analyze the established approaches in law enforcement practice towards solution of the aforementioned problem. Methodological framework includes the comparative-legal method and such formal-logical methods, as analysis, synthesis and induction. The relevance and practical importance are substantiated by the subject of research – the law enforcement practice formed by the Russian judicial authorities over the recent years. The conclusion is made on the need for elimination of the existing gap in the normative-legal regulation by amending the current procedural legislation.
THE EVENT OF AGGRESSION AS A SOCIAL PROBLEM
Authors: Chmielewska Maria
Published: April 2020

Aggression is a common phenomenon today in all areas of activities. At present, aggression is identified as an inherent element of life of a young person and it has serious consequences in his private and social life. There is no doubt that “in every person there is violence and aggression, only the conditions in which he or she is, determine to reveal this tendency.” The author wonders not about the possibility of eliminating aggression, but on limiting it and trying to control this phenomenon
CIVIC EDUCATION AND SHAPING ELITES IN SOCIAL THEORY OF JOSÉ ORTEGA Y GASSET
Authors: Charchuła Jarosław
Published: April 2020

The social concept of José Ortega y Gasasse was developed at the beginning of the twentieth century but still remains valid. This article highlights in a special way the importance of civic education as a foundation for building a democratic society and shaping elites. In the light of Ortega y Gasset’s liberalism, important assumptions regarding freedom, civic education as well as the formation of elites are being analysed. These issues will be analysed in the context of assumptions regarding the principles of shaping the privacy of each citizen, which is the centre and source of all activities of the individual. Properly shaped privacy is the main goal of civic education and guarantees the formation of elites in society.
Space-temporal evaluation of biophysical parameters in the High Ipanema watershed by remote sensing
Authors: Oliveira Jose Diorgenes Alves , De Medeiros Biancca Correia , Da Silva Jhon Lennon Bezerra , Moura Geber Barbosa de Albuquerque , Lins Frederico Abraão Costa , Nascimento Cristina Rodrigues , Lopes Pabrício Marcos Oliveira
Published: April 2020

The High Ipanema watershed is located in a semiarid region and because of this, becomes more vulnerable and susceptible to the effects of environmental changes and the degradation process, it has serious economic and socio-environmental implications. In recent years with the advancement of remote sensing based on satellite imagery or other platforms, it has become possible to monitor different and large areas of the various biomes in the world. The objective of this study was to identify changes in the vegetation cover conditions in the Alto Ipanema watershed, using spectral analyzes of Landsat-8 OLI / TIRS satellite images, using remote sensing techniques. Landsat-8 OLI / TIRS satellite images were obtained from the United States Geological Survey – USGS, on 10/12/2013, 14/01/2015 and 12/08/2016, where they were processed from ERDAS IMAGINE® Software, version 9.1. The thematic maps of biophysical parameters were processed by ArcGis® 10.2.2 Software. With the biophysical parameters analyzed, it was found that the northwest portion of the watershed presents a considerable area of exposed soils with indication of a high degree of susceptibility to degradation and that the biophysical parameters evaluated by the SEBAL algorithm are efficient in understanding the dynamics of spatial and temporal areas of semiarid environments.
PERAN GURU PENDIDIKAN AGAMA ISLAM DALAM PEMBINAAN AKHLAKUL KARIMAH PESERTA DIDIK DI SMA MUHAMMADIYAH 8 CERME GRESIK
Authors: Ridwan Wasis , Ladamay Ode Moh Man Arfa
Published: April 2020

Abstrak: Fokus penelitian dalam penulisan skripsi ini adalah (1) Bagaimana metode pembinaan akhlakul karimah peserta didik melalaui kegiatan keagamaan di SMA Muhammadiyah 8 Cerme Gresik? (2) Bagaimana evaluasi pembinaan akhlakul karimah peserta didik melalui kegiatan keagamaan di SMA Muhammadiyah 8 Cerme Gresik? (3) Apa faktor pendukung dan penghambat pelaksanaan pembinaan akhlakul karimah peserta didik melalui kegiatan keagamaan? Adapun tujuan dari penelitian ini adalah 1. Untuk mengetahui metode pelaksanaan pembinaan akhlakul karimah peserta didik melalui kegiatan keagamaan, 2. Mengetahui evaluasi pelaksanaan pembinaan akhlakul karimah peserta didik melalui kegiatan keagamaan, 3. Mengetahui faktor pendukung dan penghambat pelaksanaan pembinaan akhlakul karimah peserta didik melalui kegiatan keagamaan.
Інформаційні технології оптимізації роботи приватного блокчейн за допомогою вибору алгоритму консенсусу
Authors: Золотарьова І.О. , Плеханова Г.О.
Published: April 2020

В роботі розглянуто проект з відкритим кодом Ethereum Blockchain, що є одним з найпопулярніших представників блокчейн-технологій. В своїй канонічній реалізації Ethereum працює як відкрита публічна децентралізована система, що базується на алгоритмі консенсусу PoW та дозволяє користувачам керувати власною криптовалютою, розробляти та розгортати розумні контракти на базі EVM (Ethereum Virtual Machine), взаємодіяти з розумними контрактами інших користувачів. Оскільки такий алгоритм не задовольняє вимогам більшості корпоративних проектів на базі Ethereum Blockchain, був проведений порівняльний аналіз найпопулярніших алгоритмів консенсусу і на основі результатів цього аналізу проведена оптимізація роботи приватного блокчейн за допомогою вибору алгоритму консенсусу.
Дослідження моделі сегментації зображень з використанням розподілених режимів TensorFlow та згорткової нейронної мережі U-Net
Authors: Мінухін С.В.
Published: April 2020

Розглянуто модель сегментації медичних зображень з використанням різних розподілених режимів бібліотеки машинного навчання TensorFlow та згорткові мережі U-Net. Проведено аналіз можливостей розподілених обчислень для їх використання в TensorFlow. Описана побудована архітектура кластера робочих станцій та послідовність кроків для проведення експериментальних досліджень. Отримано оцінки втрат при навчанні у вигляді коефіцієнта Дайса, які свідчать про переваги використання синхронного режиму розподіленого навчання та в умовах масштабованості розгорнутого кластера.
Three recommendations based on a comparison of the reliability and validity of the predominant models used in research on the empirical structure of psychopathology
Authors: Forbes Miriam K. , Greene Ashley Lauren , Levin-Aspenson Holly Frances , Watts Ashley L. , Hallquist Michael , Lahey Benjamin , Markon Kristian Eric , Patrick Christopher , Tackett Jennifer L , Waldman Irwin , Wright Aidan G.C. , Caspi Avshalom , Ivanova Masha Y. , Kotov Roman , Samuel Douglas B , Eaton Nicholas R , Krueger Robert
Published: April 2020

The present study compared the primary models used in research on the structure of psychopathology (i.e., correlated factor, higher-order, and bifactor models) in terms of structural validity (model fit and factor reliability), longitudinal measurement invariance, concurrent and prospective predictive validity in relation to important outcomes, and longitudinal consistency in individuals’ factor score profiles. Two simpler operationalizations of a general factor of psychopathology were also examined—a single-factor model and a count of diagnoses. Models were estimated based on structured clinical interview diagnoses in two longitudinal waves of nationally representative data from the United States (n = 43,093 and n = 34,653). Models that included narrower factors (fear, distress, and externalizing) were needed to capture the observed multidimensionality of the data. In the correlated factor and higher-order models these narrower factors were reliable, largely invariant over time, had consistent associations with indicators of adaptive functioning, and had moderate stability within individuals over time. By contrast, the fear and distress specific factors in the bifactor model did not show good reliability or validity throughout the analyses. Notably, the general factor of psychopathology (p-factor) performed similarly well across tests of reliability and validity regardless of whether the higher-order or bifactor model was used; the simplest (single-factor) model was also comparable across most tests, with the exception of model fit. Given the limitations of categorical diagnoses, it will be important to repeat these analyses using dimensional measures. We conclude that when aiming to understand the structure and correlates of psychopathology it is important to: 1) look beyond model fit indices to choose between different models; 2) examine the reliability of latent variables directly; and 3) be cautious when isolating and interpreting the unique effects of specific psychopathology factors, regardless of which model is used.
A Personal Respirator Specification for Health-care Workers Treating COVID-19 (PeRSo)
Authors: Elkington Paul , Dickinson Alexander , Mavrogordato Mark , Spencer Dan , Gillams Ric , De Grazia Antonio , Rosini Sebastian , Baquero Diana Garay , Diment Laura , Mahobia Nitin , Morgan Hywel
Published: April 2020

The SARS-CoV-2 virus infection is a rapidly spreading global pandemic. Recent media coverage has highlighted the importance of protecting health-care workers together with issues surrounding availability and suitability of Personal Protective Equipment (PPE). Around 20% of healthcare workers treating COVID19 cases in Italy have become infected which leads to staff absence at a critical point during the pandemic, and unfortunately in some cases mortality.PPE plays a major role in control programs. Standard PPE such as N95/FFP3 facemasks have limitations such as an ineffective seal during talking or after prolonged use, face shapes which cannot be adequately fitted, and logistical issues ensuring availability of the correct mask for each person. Furthermore, global stock is low, and issues around diagnostic testing specificity and turnaround time may lead to infectious patients receiving care from health care staff who are not wearing appropriate PPE. To address acute shortcomings in PPE availability, we have developed a simple pressurised air purified respirator unit, incorporating a combination of inexpensive and widely available components parts. The prototype was developed to minimise the number and complexity of manufacturing steps with the intention that derivative versions could be developed in many different parts of the world, including low resource settings with minor modification, where transmission could be rapid amongst high population densities.The “Personal Respirator – Southampton” (PeRSo) delivers HEPA filtered air from a battery powered fan-filter assembly through a lightweight hood/face mask that can be comfortably worn for several hours. Initial user feedback provided by doctors and nurses shows the PeRSo prototype was preferred to standard N95/FFP3 masks, being more comfortable, reducing time lost placing and removing PPE between patients, and allowing better communication. Preliminary tests indicate that the device removes microbes and passes the “fit tests” widely used to evaluate face masks. Full verification of the safety and the duration of effectiveness and durability of the device is required, as part of translation into use. Rapid upscale of production is required to protect healthcare workers from infection while the global situation accelerates, so that they can look after patients during the peak of the pandemic.
Acceptability and Utility of an Open-Access, Online Single-Session Intervention Platform for Adolescent Mental Health
Authors: Schleider Jessica L. , Dobias Mallory , Sung Jenna , Mumper Emma , Mullarkey Michael C
Published: April 2020

Background. Many youths with mental health needs are unable to access care. Single-session interventions (SSIs) have helped reduce youth psychopathology across multiple trials, suggesting promise to broaden access to effective, low-intensity supports. Online, self-guided SSIs may be especially scalable, particularly if freely available for as-needed use. However, online SSIs’ acceptability and effects have remained unexamined outside of controlled trials, leaving their practical utility poorly understood. Objective. We evaluated the perceived acceptability and proximal effects of Project YES (Youth Empowerment & Support; www.schleiderlab.org/yes), an open-access platform offering three online SSIs for youth internalizing distress. Method. After selecting one of three SSIs to complete, youth participants (ages 11-17 years) reported pre- and post-SSI levels of clinically-relevant outcomes that SSIs may target (e.g. hopelessness; self-hate) and perceived SSI acceptability. User-pattern variables, demographics, and depressive symptoms were collected to characterize youths engaging with YES. Results. From 9/2019-3/2020, 694 youths accessed YES, of whom 539 began and 187 completed a 30-minute, self-guided SSI. SSI completers reported clinically-elevated depressive symptoms, on average, and were diverse on several dimensions (53.75% non-white; 78.10% female; 43.23% sexual minorities). Regardless of SSI selection, completers reported pre- to post-program reductions in hopelessness (dav = .53; dz = .71), self-hate (dav = .32; dz = .61), perceived control (dav = .60; dz = .72) and agency (dav = .39; dz = .50). Youths rated all SSIs as acceptable (e.g., enjoyable; likely to help peers). Conclusions. Results support the perceived acceptability and utility of open-access, free-of-charge SSIs for youth experiencing internalizing distress.