bluuebunny/crossref_metadata_2025 huggingface dataset:
Epidemiology and economic losses of rotavirus infection associated with hospitalization of Armenian children
Authors: Hovhannisyan Alvard , Mkhoyan Anna , Gyulazyan Naira , Asoyan Vigen , Navoyan Tsoghik , Gevorgyan Zaruhi , Simonyan Marta
Published: May 2019

Introduction: Rotavirus (RV) is the leading cause of severe diarrhea-associated morbidity and mortality among children worldwide. Limited data exist on the epidemiology and burden of rotavirus gastroenteritis in Armenia. The purpose of this study is to estimate the economic losses and describe the epidemiological characteristics of rotavirus infections in hospitalized children in Armenia.

Methodology: A retrospective chart review was performed of all children (aged < 5 years) with Rotavirus infection admitted to the “Nork” Republican Infection Clinical Hospital in Yerevan, the capital of Armenia, between January and July 2014. Criteria of inclusion were age under 5 years old and presence of RV antigen in stool by enzyme linked immunosorbent assay.

Results: The total number of patients was 126; average age was 28.7 ± 13.3 months; 54.8% were male. The highest number of cases (31.8%) was observed in April. Most of the patients (71.4%) were hospitalized in the first three days, demonstrating an acute onset of the disease. In total 19% of the patients had received RV vaccine and, despite this, were infected with RV. Based on bacteriological examination of stool, 18.3% of patients had RV infection combined with pathogenic or conditional pathogenic microflora. All patients spent 817 days in total in the hospital. Economic losses associated with hospitalization were 16340000 AMD (≈ 33346 USD).

Conclusion: Rotavirus carries significant morbidity and economic losses. Comprehensive estimates of the disease characteristics and introduction of a national immunization program against RV initiated in 2012 may decrease this burden. Further studies to evaluate the feasibility and cost-effectiveness of such a program are warranted.
Enterobacterial infection in Saudi Arabia: First record of Klebsiella pneumoniae with triple carbapenemase genes resistance
Authors: Khan Mubashir Ahmad , Mohamed Amr M , Faiz Aftab , Ahmad Jawwad
Published: May 2019

Introduction: Carbapenemase producing Enterobacteriaceae are emerging as important pathogens worldwide with serious effects on patients’ outcome. The study aimed to investigate the emergence of carbapenemases associated with enterobacterial infection in Western region of Saudi Arabia.

Methodology: Clinical isolates from suspected patients with enterobacterial infection were investigated over a one-year period from four tertiary care hospitals of Makkah, Saudi Arabia. All isolates were identified using Vitek-2 system and then screened for potential carbapenemase production using disk diffusion test. Suspected isolates with reduced susceptibility to carbapenems were further investigated for blaNDM-1, blaKPC and blaOXA-48 resistant genes.

Results: Out of 120 confirmed Enterobacteriaceae isolates, Klebsiella pneumoniae and Escherichia coli comprised the largest proportion (35% and 34.2%, respectively) of encountered infections. Twenty-six (21.7%) isolates showed resistance to carbapenems, the majority of which (21/26) were K. pneumoniae. Remarkably, 17 isolates carried triple resistant genes KPC/NDM-1/OXA-48 while the other 4 carried double resistant genes (KPC/OXA-48) or (NDM-1/OXA-48). The current study revealed that the mentioned triple resistance genes have the higher incidence with significant association risk among males (COR 4.5; CI: 1.9-17.3; P = 0.018), non-Saudi nationalities (COR 4.9; CI: 1.5-19.3; P = 0.003), ICU-obtained specimens (COR 3.6; CI: 1.5-8.4; P = 0.002) and blood specimens (COR 2.8; CI: 1.1-6.9; P = 0.02).

Conclusion: Multidrug-resistant Enterobacteriaceae isolates in particular K. pneumoniae co-harboring KPC, NDM-1 and OXA-48 genes are emerging in Western region, Saudi Arabia. This is the first record of triple carbapenemase genes co-producing K. pneumoniae associated with enterobacterial infection.
Norovirus outbreak among students of a boarding school in Kluang, Johor, Malaysia
Authors: Subahir Mohamad Nizam , Jeffree Mohammad Saffree , Hassan Mohd Rohaizat , Razak Md Faizul Abd , Mohamad Syarifah Noor Ghulam , Fong Siat Yee , Ahmed Kamruddin
Published: May 2019

Introduction: Norovirus (NoV) is a contagious virus causing acute gastroenteritis and is mainly responsible for diarrheal outbreak in closed settings. The aims of this study were to describe the epidemiological characteristic of an outbreak in a boarding school, to assess the extent of the outbreak and to implement appropriate control measures.

Methodology: A descriptive study was conducted to describe the epidemiological characteristics of the outbreak. Data on demographic details, onset of abdominal symptoms, food intake history and contact with ill person three days prior to illness were obtained.

Results: Twelve fresh stool and 14 food samples were tested for NoV and enteric pathogens, respectively. Out of 745 students, 42 (5.6%) were infected during this outbreak. Predominant clinical features were diarrhea (76.1%), vomiting (71.4%) and abdominal pain (67%). Eight (67%) stool samples and six (43.9%)food samples were positive for NoV and total coliforms, respectively. The dissemination of the disease was due to poor hygiene practices among students. Quarantine was imposed until the last case on September 28, 2016. The outbreak was declared over on September 30, 2016.

Conclusions: A NoV outbreak was determined first time in Malaysia. Environmental assessment showed poor hygienic conditions in the school’s kitchen. The number of infected students increased considerably despite the implementation of preventive and control measures. Quarantine was effective to stop the outbreak which is characteristics of NoV outbreak.
Enterobacteria in the 21st century: a review focused on taxonomic changes
Authors: Morales-López Soraya , Yepes Jayr A , Prada-Herrera Juan C , Torres-Jiménez Augusto
Published: May 2019

Introduction: Enterobacteria are the main group causing infections in humans. The aim of this review is to present the new genera and the taxonomic changes that the Enterobacteriacea family has experienced in recent years.

Methodology: a systematic search of papers published in databases from January 2000 to July 2018 was done. Additionally, the bibliographic references of each document were reviewed and each paper citing the article was reviewed in search of clinical cases.

Results: Nineteen new genera of Enterobacteria have been described since 2000. The genera Yersinia, Morganella and Erwinia do not belong to the family Enterobacteriacea anymore.

Conclusions: for an adequate clinical and epidemiological interpretation, it is advisable to update the libraries of the commercial systems used for the identification of the microorganisms, as well as to train the staff in the taxonomic changes of microorganisms.
Indicadores de qualidade do fornecimento de energia no Brasil
Authors: Maestri Cláudia Olímpia Neves Mamede , Andrade Maria Elisabeth Moreira Carvalho
Published: May 2019

O objetivo deste estudo foi identificar se há relação entre custos operacionais, investimentos, satisfação do consumidor e a qualidade de fornecimento de energia no Brasil. A amostra foi composta por concessionárias do setor de distribuição de energia no Brasil, no período de 2010 até 2016. Os dados foram coletados a partir da ANEEL e a execução dos testes aconteceu por dados em painel estático e dinâmico. Os resultados por GMM System apontam que a melhoria da qualidade do fornecimento de energia advém da continuidade da redução das taxas de variação de DEC e FEC, em que as taxas de variação desses indicadores (ΔDEC, ΔFEC) carregam memória de períodos anteriores, sendo que uma redução dessas taxas num determinado período influencia para que a redução seja mantida no próximo período, o que melhora a qualidade do fornecimento de energia. Os investimentos melhoram a qualidade do fornecimento de energia em termos de redução da taxa de frequência das interrupções do fornecimento de energia (ΔFEC) e de redução da taxa de frequência de reclamações dos consumidores (ΔFER). O índice ANEEL de satisfação do consumidor (IASC) mostra que a percepção geral da satisfação do cliente proporciona a melhoria da qualidade do fornecimento de energia em termos de ΔDEC, ΔDER e ΔFER.
Avaliação higiênico-sanitária dos estabelecimentos com o selo "açaí bom" da vigilância sanitária
Authors: Silva Fernanda Silva , Macedo Silva Alana França , Sousa Consuelo Lúcia , Souza Jesus Nazareno
Published: May 2019

O presente trabalho teve como objetivo avaliar as condições higiênico-sanitárias de estabelecimentos que processam e comercializam a bebida de açaí e que possuem o selo de qualidade “Açaí Bom” do Departamento de Vigilância Sanitária da cidade de Belém/PA. Foram avaliados, 37 dos 163 estabelecimentos processadores de açaí com selo de qualidade. Para avaliação das BPF, foi elaborado um checklist, composto por 121 requisitos de verificação agrupados em 5 itens por assunto. Após a aplicação do checklist os estabelecimentos foram classificados em grupos em função da conformidade dos itens.  Assim o Grupo 1 - BOM (76 a 100% de atendimento dos itens), Grupo 2 - REGULAR (51 a 75% de atendimento dos itens) e Grupo 3 - RUIM (0 a 50% de atendimento dos itens). De acordo com o percentual de conformidades geral dos estabelecimentos inspecionados, verificou-se que 62 % foram classificados no grupo 2 (REGULAR), por terem atendido de 51 a 75 % dos itens preconizados no checklist, e  38 % no grupo 3 (RUIM) por terem  apresentado percentual de conformidade abaixo de 50 % . Embora a vigilância sanitária através da Casa do Açaí realize o monitoramento dos estabelecimentos com vistorias frequentes, coleta da bebida para análises e o treinamento dos manipuladores faz-se necessário uma maior conscientização dos mesmos em relação à importância da correta manipulação e processamento do fruto evitando assim potenciais riscos a saúde do consumidor, bem como a conscientização dos consumidores para assumirem uma conduta mais exigente em relação aos estabelecimentos em que adquirem a bebida.
O estágio curricular supervisionado de química licenciatura: um olhar sobre teses e dissertações publicadas na BDTD
Authors: Deus Andréia Florêncio Eduardo de , Sutil Noemi
Published: May 2019

O estágio curricular nos cursos de licenciatura em Química tem sido objeto de estudos em muitas pesquisas nos programas de pós-graduação stricto sensu. Nesse escopo, neste trabalho foram analisadas teses e dissertações publicadas na Biblioteca Digital Brasileira de Teses e Dissertações (BDTD), no período de 2000 a 2017, abrangendo esse tema. Foram identificadas oito dissertações e oito teses, a partir da utilização do descritor “estágio de Química licenciatura”. Esses materiais foram analisados em viés da Análise de Conteúdo; tais produções foram organizadas em quatro categorias definidas a posteriori quanto ao objetivo de estudo. Os trabalhos analisados demonstram pontos em comum quanto à estrutura dos cursos de Licenciatura em Química e a função do estágio. Diversos autores apontam a predominância da racionalidade técnica e a dificuldade de comunicação em todo o processo formativo do professor de Química. Salienta-se, dessa forma, que pesquisas desenvolvidas nesta área precisam ser compartilhadas, viabilizando novas reflexões. Para tal, defende-se a existência de espaços comunicativos que envolvam todos os sujeitos, de forma igualitária, nas discussões e reflexões sobre o processo formativo docente em Química e seus objetivos.
Desenvolvimento dos profissionais que atuam na educação bilíngue para surdos
Authors: Filietaz Marta Rejane Proença , Da  Cruz Alisson Luan , Pachiel Renata Costa
Published: May 2019

Esta pesquisa tem como objetivo discutir sobre o desenvolvimento dos profissionais contemplados no Decreto nº 5.626/2005, que ganham importância significativa no processo educacional dos alunos surdos numa perspectiva bilíngue, considerando a Língua Brasileira de Sinais (Libras) como primeira língua e a Língua Portuguesa como segunda língua na modalidade escrita. Assim, destacamos a atuação dos Tradutores e Intérpretes em Língua de Sinais e Língua Portuguesa (TILS), o professor Bilíngue, o professor surdo e o instrutor de Libras. A metodologia escolhida para a realização deste estudo buscou os pressupostos teóricos baseados na pesquisa com abordagem qualitativa. Nesse sentido, a investigação se pautará por uma práxis com aportes na abordagem sócio-histórica de cunho dialético, considerando o resgate da trajetória histórica e cultural sobre a concepção educacional dos profissionais que atuam na Educação dos surdos. Em uma primeira etapa efetiva-se uma discussão sobre as questões do contexto da educação dos surdos e suas implicações nos processos de formação e atuação dos profissionais inseridos em um contexto de educação bilíngue. Esses temas serão balizados a partir de perspectivas apontadas por Schubert (2015), Andreis-Witkoski (2012, 2013), Filietaz e Tsukamoto (2011), Lacerda (2009), Quadros (2007, 2010), Filietaz (2006, 2016), bem como na legislação que orienta as práticas educativas em contextos de inclusão, como a LDB 9.394/1996, o Decreto nº 5.626/2005 e a Lei Federal nº 13.146/2015. A segunda etapa foi estruturada a partir de entrevistas semiestruturadas realizadas com os profissionais que atuam em três escolas, na cidade de Curitiba e na área metropolitana, que utilizam a proposta bilíngue. É inegável a grande conquista por meio do Decreto nº 5.626/2005 que passa a dar novos rumos e desafios de como assegurar os direitos à educação dos surdos, com acesso e permanência na escola para o desenvolvimento cognitivo, social, cultural, entre outros pontos citados nos documentos legais.
O podcast sobre as concepções de surdez como REA no ensino superior
Authors: Shimazaki Neide Mitiyo
Published: May 2019

Esta pesquisa apresenta os resultados das elaborações de Podcast sobre os conceitos referentes à surdez, os quais foram disponibilizados como Recursos Educacionais Abertos – REA. O problema deste estudo consiste na falta de estudos e pesquisas sobre a surdez após o Decreto nº 5.626/2005 e sobre os conceitos que envolvem a surdez que diferenciam os surdos dos deficientes auditivos, com a questão: os alunos do Ensino Superior podem distinguir o conceito da surdez por meio da produção de Podcast? De forma que, o objetivo deste relato de experiência consiste em analisar a apreensão do conceito da surdez que se distingue na concepção clínico-terapêutica e sociopedagógica no contexto da disciplina de Libras, por meio do Podcast produzido pelos alunos do curso de licenciatura em Química. A metodologia de pesquisa enquadra-se na pesquisa-ação com abordagem qualitativa, ancorada no suporte teórico dos estudos de Fernandes (2007) e Slomski (2012) que diferenciam os surdos dos deficientes auditivos de acordo com as concepções clínico-terapêutica e sociopedagógica, além das diretrizes dos REA para o Ensino Superior traçados pela Organização das Nações Unidas para a Educação, a Ciência e a Cultura (UNESCO) e Commonwealth of Learning (COL). Assim, elaborou-se seis Podcasts que foram disponibilizados em rede como REA, para que os profissionais da educação possam atualizarem-se sobre os conceitos de surdez, após o Decreto nº 5.626/2005. Acredita-se que os Podcasts produzidos constituem referenciais inéditos com as informações conceituais sobre os surdos na concepção clínico-terapêutica e sociopedagógica. Também, que o conhecimento adquirido para destacar os valores humanos e fundamentais para os professores comprometidos em humanizar a educação e a sociedade podem promover uma aprendizagem significativa.
Formação de professores: a disseminação do conhecimento por meio de Recursos Educacionais Abertos
Authors: Fialho Neusa Nogueira
Published: May 2019

Entendemos que o processo de formação docente é complexo, incerto e repleto de desafios, por esse motivo precisa ser repensado, refletido e renovado constantemente. O mundo moderno oferece uma pluralidade de recursos educacionais, muitos deles oriundos das tecnologias digitais em ascensão. Neste universo tão vasto encontramos os Recursos Educacionais Abertos - REA que colaboram com a disseminação do conhecimento e podem enriquecer significativamente o trabalho docente. Neste sentido, o objetivo deste trabalho é analisar os resultados de um curso de formação inicial com proposta de criação, produção e publicação de REA para o ensino e aprendizagem de Química. O curso foi desenvolvido em uma universidade de grande porte da cidade de Curitiba-PR e contou com a participação de dezesseis estudantes do quarto período do curso de Química. Os estudantes produziram oito sequências de aulas inovadoras e de qualidade, com licenciamento aberto, para serem utilizados por professores de Química do Ensino Médio. A experiência vivenciada neste trabalho corresponde a uma das etapas de uma tese de doutorado que tomou por base os princípios da pesquisa-ação e teve como instrumentos de coleta de dados a observação participante e o uso de um questionário semiestruturado. Os trabalhos no formato de REA foram publicados no site YuduExpress, porém para maior divulgação, os REA produzidos também foram depositados em um repositório denominado: REA para o ensino de Química, criado pela autora deste trabalho. Os resultados obtidos foram substanciais tendo em vista que proporcionou aos futuros professores momentos de intensa interação, colaboração, cocriação e coaprendizagem.
Idealismo e materialismo: matrizes filosóficas do pensamento educacional
Authors: Andrade Zinara Marcet de , Ramos Junior Armenes De Jesus
Published: May 2019

Existem, apesar de inúmeras controvérsias, duas grandes matrizes teórico-filosóficas que orientam a concepção de educação escolar ao longo dos séculos e todos os aspectos que lhe dizem respeito: o idealismo e o materialismo. Cada uma dessas correntes filosóficas teve vários desdobramentos e consequências diversas no fazer docente e, sobretudo, na aprendizagem dos estudantes. Logo, o objetivo do presente texto é resgatar tais concepções nas suas origens a fim de contribuir com a prática pedagógica consciente e que realmente contribua com a qualidade da escola pública e com elevação cultural da classe trabalhadora.
Neutrophil Extracellular Traps May Contribute to the Pathogenesis in Adult-onset Still Disease
Authors: Ahn Mi-Hyun , Han Jae Ho , Chwae Young-Jun , Jung Ju-Yang , Suh Chang-Hee , Kwon Ji Eun , Kim Hyoun-Ah
Published: May 2019

Objective.

Release of neutrophil extracellular traps (NET) has been described as an effector mechanism of polymorphonuclear neutrophils in several inflammatory diseases. Thus, this study was performed to evaluate the role of NET in the pathogenesis of adult-onset Still disease (AOSD).

Methods.

We determined the serum levels of NET molecules and investigated their associations with clinical disease activities in patients with AOSD. Further, we analyzed the differences in the NETosis response in AOSD patients compared to healthy controls (HC). To explore the in vivo involvement of NET in AOSD, we performed immunohistochemical analysis of skin and lymph node (LN) biopsies for proteins related to NET in patients with active AOSD.

Results.

Serum levels of cell-free DNA, myeloperoxidase (MPO)-DNA complex, and α-defensin were significantly increased in patients with AOSD compared to HC. Serum levels of the NET molecules, cell-free DNA, MPO-DNA, and α-defensin were correlated with several disease activity markers for AOSD. In followup of patients with AOSD after treatment with corticosteroid, the levels of cell-free DNA and α-defensin decreased significantly. On immunohistochemistry, neutrophil elastase–positive and MPO-positive inflammatory cells were detected in skin and LN of patients with AOSD, and were expressed in fiber form in the lesions. The serum from patients with active AOSD induced NETosis in neutrophils from HC. NET molecules induced interleukin 1β production in monocytes, representing a novel mechanism in the pathogenesis of AOSD.

Conclusion.

The findings presented here suggest that NET may contribute to the inflammatory response and pathogenesis in AOSD.
Effect of Osteoarthritis on Work Participation and Loss of Working Life–years
Authors: Kontio Tea , Viikari-Juntura Eira , Solovieva Svetlana
Published: May 2019

Objective.

To examine to what extent disabling osteoarthritis (OA), leading to a prolonged sickness absence (SA), interferes with work participation and shortens working life–years.

Methods.

A total of 4704 wage earners aged 30 to 59 years, whose SA due to OA started in 2006, were followed until October 31, 2014. Kaplan–Meier analysis was used to plot sustained (at least 28 consecutive days) return-to-work curves. The associations of potential determinants with early exit from paid employment were examined applying Cox proportional hazards regression analysis. Years expected to be spent in different work participation statuses until statutory retirement age were estimated based on daily work participation statuses using adapted Sullivan method.

Results.

Persons with knee OA showed the fastest, and persons with hip OA the slowest, sustained return to work. Although most participants typically were at work during the first year of followup, a considerable proportion was permanently retired. Male sex, older age, low education, long initial SA, and having not returned to work sustainably, as well as receiving vocational rehabilitation, predicted early exit from paid employment during the followup. Overall, only 45–53% of potential working life–years were estimated to be spent at work, being highest for the oldest age group.

Conclusion.

Our study showed a considerable effect of OA on work participation and working life duration. Clinicians should avoid prescription of long SA or temporary work disability due to OA without a clear treatment or return-to-work plan.
Association of 17 Definitions of Remission with Functional Status in a Large Clinical Practice Cohort of Patients with Rheumatoid Arthritis
Authors: Carvalho Pedro D. , Ferreira Ricardo J.O. , Landewé Robert , Vega-Morales David , Salomon-Escoto Karen , Veale Douglas J. , Chopra Arvind , da Silva José A.P. , Machado Pedro M.
Published: May 2019

Objective.

To compare the association between different remission criteria and physical function in patients with rheumatoid arthritis followed in clinical practice.

Methods.

Longitudinal data from the METEOR database were used. Seventeen definitions of remission were tested: American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) Boolean-based; Simplified/Clinical Disease Activity Index (SDAI/CDAI); and 14 Disease Activity Score (DAS)-based definitions. Health Assessment Questionnaire (HAQ) ≤ 0.5 was defined as good functional status. Associations were investigated using generalized estimating equations. Potential confounders were tested and sensitivity analyses performed.

Results.

Data from 32,915 patients (157,899 visits) were available. The most stringent definition of remission was the ACR/EULAR Boolean-based definition (1.9%). The proportion of patients with HAQ ≤ 0.5 was higher for the most stringent definitions, although it never reached 100%. However, this also meant that, for the most stringent criteria, many patients in nonremission had HAQ ≤ 0.5. All remission definitions were associated with better function, with the strongest degree of association observed for the SDAI (adjusted OR 3.36, 95% CI 3.01–3.74).

Conclusion.

The 17 definitions of remission confirmed their validity against physical function in a large international clinical practice setting. Achievement of remission according to any of the indices may be more important than the use of a specific index. A multidimensional approach, targeted at wider goals than disease control, is necessary to help all patients achieve the best possible functional status.
Diffuse Idiopathic Skeletal Hyperostosis in Smokers and Restrictive Spirometry Pattern: An Analysis of the COPDGene Cohort
Authors: Oudkerk Sytse F. , Mohamed Hoesein Firdaus A.A. , Öner F. Cumhur , Verlaan Jorrit-Jan , de Jong Pim A. , Kuperus Jonneke S. , Cho Michael , McDonald Merry-Lynn , Lynch David A. , Silverman Edwin K. , Crapo James D. , Make Barry J. , Lowe Katherine E. , Regan Elizabeth A.
Published: May 2019

Objective.

Diffuse idiopathic skeletal hyperostosis (DISH) is a condition characterized by bony proliferation at sites of tendinous and ligamentous insertions in the spine. Spinal mobility is reduced in DISH and may affect movement in the thorax, potentially leading to restrictive pulmonary function. This study investigated whether DISH is associated with restrictive spirometric pattern (RSP) in former and current smokers.

Methods.

Participants (n = 1784) with complete postbronchodilator spirometry who did not meet spirometric criteria for chronic obstructive pulmonary disease (COPD) at time of enrollment in the COPDGene study were included in this study. Subjects were classified as RSP if they had forced expiratory volume in 1 s(FEV1) to forced vital capacity (FVC) ratio > 0.7 with an FVC < 80%. Computed tomography (CT) scans were scored for the presence of DISH in accordance with the Resnick criteria. Chest CT measures of interstitial and alveolar lung disease, clinical symptoms, health surveys, and 6-min walking distance were recorded. Uni- and multivariable analyses were performed to test the association of DISH with RSP.

Results.

DISH was present in 236 subjects (13.2%). RSP was twice as common in participants with DISH (n = 90/236, 38.1%) compared to those without DISH (n = 301/1548, 19.4%; p < 0.001). In multivariable analysis, DISH was significantly associated with RSP (OR 1.78; 95% CI 1.22–2.60; p = 0.003) after adjusting for potential confounders. The RSP group with and without DISH had significantly worse spirometry, dyspnea, St. George’s Respiratory Questionnaire score, BODE index (Body mass index, airflow Obstruction, Dyspnea and Exercise capacity), and Medical Outcomes Study Short Form-36 questionnaire score.

Conclusion.

In heavy smokers with an FEV1/FVC ratio > 0.70, DISH is associated with RSP after adjustment for intrinsic and extrinsic causes of restrictive lung function. (Clinical trial registration number: NCT00608764.)
A Monogenic Disease with a Variety of Phenotypes: Deficiency of Adenosine Deaminase 2
Authors: Özen Seza , Batu Ezgi Deniz , Taşkıran Ekim Z. , Özkara Hatice Asuman , Ünal Şule , Güleray Naz , Erden Abdulsamet , Karadağ Ömer , Gümrük Fatma , Çetin Mualla , Sönmez Hafize Emine , Bilginer Yelda , Ayvaz Deniz Çağdaş , Tezcan Ilhan
Published: May 2019

Objective.

Deficiency of adenosine deaminase 2 (DADA2) is an autosomal recessive autoinflammatory disorder associated with ADA2 mutations. We aimed to investigate the characteristics and ADA2 enzyme activities of patients with DADA2 compared to non-DADA2 patients.

Methods.

This is a descriptive study of 24 patients with DADA2 who were admitted to the Adult and Pediatric Rheumatology, Pediatric Haematology, and Pediatric Immunology Departments of Hacettepe University. All ADA2 exons were screened by Sanger sequencing. Serum ADA2 enzyme activity was measured by modified spectrophotometric method.

Results.

Twenty-four patients with DADA2 were included: 14 with polyarteritis nodosa (PAN)-like phenotype (Group 1); 9 with Diamond-Blackfan anemia (DBA)-like features, and 1 with immunodeficiency (Group 2). Fourteen PAN-like DADA2 patients did not have the typical thrombocytosis seen in classic PAN. Inflammatory attacks were evident only in Group 1 patients. Serum ADA2 activity was low in all patients with DADA2 except one, who was tested after hematopoietic stem cell transplantation. There was no significant difference in ADA2 activities between PAN-like and DBA-like patients. In DADA2 patients with one ADA2 mutation, serum ADA2 activities were as low as those of patients with homozygote DADA2. ADA2 activities were normal in non-DADA2 patients. ADA2 mutations were affecting the dimerization domain in Group 1 patients and the catalytic domain in Group 2 patients.

Conclusion.

We suggest assessing ADA2 activity along with genetic analysis because there are patients with one ADA2 mutation and absent enzyme activity. Our data suggest a possible genotype–phenotype correlation in which dimerization domain mutations are associated with PAN-like phenotype, and catalytic domain mutations are associated with hematological manifestations.
Identifying Possible Outcome Domains from Existing Outcome Measures to Inform an OMERACT Core Domain Set for Safety in Rheumatology Trials
Authors: Klokker Louise , Berthelsen Dorthe B. , Woodworth Thasia , Andersen Kathleen M. , Furst Daniel E. , Devoe Dan , Williamson Paula R. , Suarez-Almazor Maria E. , Strand Vibeke , Leong Amye L. , Goel Niti , Boers Maarten , Brooks Peter M. , March Lyn , Sloan Victor S. , Tugwell Peter , Simon Lee S. , Christensen Robin
Published: May 2019

Objective.

The Outcome Measures in Rheumatology (OMERACT) Safety Working Group objective was to identify harm domains from existing outcome measurements in rheumatology.

Methods.

Systematically searching the MEDLINE database on January 24, 2017, we identified full-text articles that could be used for harm outcomes in rheumatology. Domains/items from the identified instruments were described and the content synthesized to provide a preliminary framework for harm outcomes.

Results.

From 435 possible references, 24 were read in full text and 9 were included: 7 measurement instruments were identified. Investigation of domains/items revealed considerable heterogeneity in the grouping and approach.

Conclusion.

The ideal way to assess harm aspects from the patients’ perspective has not yet been ascertained.
L’évolution démographique récente de la France. Naissances, décès, unions et migrations : à chacun sa saison
Authors: Breton Didier , Barbieri Magali , d’Albis Hippolyte , Mazuy Magali
Published: May 2019

Au premier janvier 2018, la France comptait près de 66,9 millions d’habitants, soit 122 300 personnes de plus que l’année précédente, mais l’accroissement annuel moyen, et tout particulièrement l’accroissement naturel, n’ont jamais été aussi faibles depuis 20 ans, voire 40 ans. L’indice conjoncturel de fécondité poursuit sa baisse, observée notamment chez les femmes les plus jeunes. Le nombre de titres de séjour délivrés augmente en 2016 (près de 220 000). La nuptialité continue de diminuer, tant pour les couples hétérosexuels que pour les couples de même sexe. En 2017, la mortalité recule de nouveau, mais le nombre de décès dépasse 600 000, chiffre lié au vieillissement de la population. Les causes de mortalité dont les évolutions sont les plus préoccupantes sont le cancer chez les femmes, les maladies par troubles mentaux et les maladies du système nerveux. Les événements démographiques ne se répartissent pas uniformément au fil de l’année : les mariages et mises en union libre sont plus souvent observés au printemps et en été, les naissances en été et à l’automne, tout comme les entrées sur le territoire ; alors que l’hiver et la fin de l’année marquent une recrudescence d’enregistrements de pacs et des pics de mortalité.
Interventions infirmières pour promouvoir la fidélisation des donneurs de sang : une revue rapide et réaliste de la littérature
Authors: Dupin Cécile Marie , Deubelbeiss Sarah , Dos Santos Rodrigues Katy , Morais De Oliveira Daycielly , Thentz Camille , Quilleau Muriel
Published: May 2019

Infirmière, Centre de transfusion des hôpitaux universitaires de Genève, Suisse Contexte : la transfusion sanguine sauve des vies. Le don du sang est un facteur clef dans les systèmes de santé. Cependant, la pénurie subsiste. Pour garantir des réserves suffisantes en sang, les services de santé ont besoin de la collaboration de donneurs volontaires. Les infirmières des centres de transfusion sont des acteurs clefs de fidélisation. Les motivations des donneurs ainsi que les interventions infirmières promouvant la fidélisation doivent être recensées et analysées. Objectif : identifier les mécanismes existants chez les donneurs pouvant être les supports d’interventions infirmières. Méthode : une revue réaliste de la littérature telle que définie par Pawson a été conduite en 2018. Les recherches d’articles ont été effectuées dans deux bases de données. Cette stratégie a permis d’identifier neuf articles scientifiques. Ils ont été analysés selon le cadre réaliste. Résultats : l’analyse a mis en évidence trois pistes d’actions : les mécanismes issus des expériences individuelles des donneurs, les interventions existantes qui permettent aux donneurs de dépasser l’intention pour concrétiser un don, enfin les interventions interactives dans la dyade entre infirmière et donneur. La relation doit favoriser une bonne expérience du don, notamment chez les nouveaux donneurs pour pouvoir influencer positivement la fidélisation.
Évaluation des effets d’une intervention infirmière sur l’adhésion thérapeutique des personnes diabétiques de type 2
Authors: Atallah Randa , Côté José , Bekarian Gariné
Published: May 2019

Introduction : le diabète constitue un problème majeur de santé publique. Contexte : des programmes éducationnels ont démontré leur efficacité sur l’amélioration du contrôle du diabète. Au Liban, aucune intervention n’a été menée jusqu’à présent. Objectif : l’objectif est d’évaluer les effets d’une intervention éducative auprès des patients diabétiques de type 2, sur l’adhésion thérapeutique. Méthode : un devis expérimental a été utilisé. L’échantillon a été formé de 136 patients diabétiques de type 2. Ils ont été randomisés et répartis en un groupe expérimental recevant l’intervention infirmière lors de deux séances d’éducation suivi de cinq appels téléphoniques au cours des deux mois suivant l’intervention et en un groupe contrôle. Les mesures ont été prises avant l’intervention et trois mois après. Résultats : comparativement au groupe contrôle, les participants du groupe expérimental ont montré une amélioration quant au sentiment d’auto-efficacité, aux comportements d’auto-soins (diète générale, diète spécifique, exercice physique et surveillance glycémique), à l’application des recommandations (diète et soins des pieds) et au taux d’HbA1c. Discussion : les résultats ont été conformes avec les études recensées. Conclusion : une éducation assurée par une infirmière améliore les comportements de santé, rehausse le sentiment d’auto-efficacité et favorise l’adhésion thérapeutique chez les diabétiques de type 2.
Évaluation et proposition d’un entretien éducatif de groupe en puériculture préparant à la sortie de la maternité
Authors: Riquet Sébastien , Margat Aurore , Giroguy Caroline , Palmaccio Guy , Bechadergue Valérie , Zakarian Carole
Published: May 2019

Introduction : un entretien éducatif de groupe en puériculture est proposé à tous les parents dans le cadre de la préparation à la sortie de la maternité. Une infirmière puéricultrice et une auxiliaire de puériculture animent un groupe de parents sur les thématiques suivantes : les rythmes du nouveau-né, le sommeil, le couchage, l’alimentation, les soins à l’enfant. Des vidéos et brochures sont utilisées comme supports didactiques. Méthode : 100 parents ont rempli un questionnaire de satisfaction qui interroge également leur sentiment de compétences. Résultats : 80 % des parents sont totalement satisfaits de la séance mais seulement 52 % se sentent globalement compétents pour prendre en soins leur enfant. 69 % concernant le couchage, 71 % sur la température et 57 % envers la prévention des infections et des accidents. La satisfaction des mères à participer est significative ( p <0.013) pour les primipares (n=46) si elles sont entendues sur leurs appréhensions. Et pour les multipares (n=35) si elles ont pu s’exprimer librement ( p <0.018) en transmettant leurs expériences. Discussion : cet entretien éducatif préparant les familles à la sortie de la maternité doit évoluer vers une articulation « par » le groupe des connaissances et des pratiques profanes où les soignants restent garants de leur validité. Il développe des compétences en puériculture pour un retour à domicile plus confiant. Le sentiment d’efficacité personnelle évalué au-dessus de la moyenne appuie l’intérêt de cette méthode d’éducation à la santé familiale.
Coordination infirmière et maladies chroniques : état des lieux des activités en médecine adulte à l’Assistance Publique-hôpitaux de Paris
Authors: Laurent Jérémy , Le Cossec Chloé , de Chambine Sophie
Published: May 2019

Introduction : la transformation des métiers infirmiers peut être une opportunité pour l’organisation de parcours de soins personnalisés pour les malades chroniques. Objectif : notre objectif était d’identifier et de décrire les activités des infirmiers de coordination (IDEC) intervenant auprès des malades chroniques dans les services de médecine adulte à l’Assistance Publique des Hôpitaux de Paris (AP-HP). Méthode : une enquête e-mail auprès des chefs de service a permis l’identification des IDEC. Des entretiens semi-dirigés ont été conduits avec les IDEC et des médecins référents afin de connaître les activités « en pratique » des IDEC. Résultats : quarante-huit IDEC ont été identifiées dans 115 services de médecine adulte contactés à l’AP-HP. Les IDEC exerçaient essentiellement des activités d’expertise et des activités de coordination. Les IDEC permettent de libérer du temps médical, les patients sont satisfaits d’avoir un interlocuteur dédié à qui s’adresser en cas de problème. Discussion : les IDEC interviennent dans de nombreuses pathologies chroniques. Leur expertise sert avant tout les malades mais aussi les professionnels de santé qui interviennent dans le parcours de soins. Ce travail alimentera la réflexion sur la transformation des métiers infirmiers, notamment depuis la reconnaissance de l’exercice infirmier en pratique avancée.
Créer un fablab à l’université : enjeux humains et institutionnels
Authors: Galan Jean-Marc , Musiani Francesca
Published: May 2019

Le fablab de l’Université Paris-Diderot a ouvert ses portes fin 2016, dans un contexte institutionnel de déploiement d’une multitude de dispositifs liés au numérique, ayant pour objectif affiché de faire de Paris-Diderot une « université dans la ville » modèle. Comment ce discours institutionnel de développement du numérique dans l’enseignement supérieur se décline-t-il dans les pratiques quotidiennes qui ont donné lieu à la naissance et au développement du fablab de Paris-Diderot ? En explorant ses débuts, les enjeux institutionnels et humains qui ont informé sa création, nous souhaitons comprendre comment les acteurs se sont saisis de cet impératif et ont été en mesure de le détourner, ou encore ont dû céder à des contraintes hiérarchiques. Pour ce faire, l’article analyse un certain nombre de choix effectués par les fondateurs du lieu, et s’interroge sur leur fondement et leur devenir.
Du bidouilleur amateur à l’informaticien, apprendre le détournement : une étude de la socialisation au hacking informatique
Authors: Larribeau Antoine
Published: May 2019

Les hackers et autres bidouilleurs informatiques développent souvent un goût pour l’informatique et les usages détournés des dispositifs numériques. Ce travail s’appuie sur une enquête ethnographique au sein d’ hackerspaces , ainsi que des entretiens avec des étudiants et professionnels de l’informatique impliqués dans le « monde hacker ». La fréquentation des hackerspaces leur permet de prolonger leur passion pour ces pratiques et d’y trouver des ressources appuis divers. Cet article se propose d’ouvrir des pistes de réflexion sur la socialisation des hackers, en questionnant les différences générationnelles ainsi que les multiples manières d’articuler exigences professionnelles et investissement au sein du hackerspace .
Le GEIQ Théâtre comme « tremplin » ? Trajectoires d’artistes du spectacle
Authors: Roux Nicolas
Published: May 2019

En se basant sur une enquête biographique et longitudinale auprès d’artistes du spectacle, l’article met d’abord en exergue la manière dont le « capital spécifique » structure les trajectoires professionnelles et met en jeu des inégalités liées à l’origine sociale, à la formation artistique et à la précocité avec laquelle la carrière a été commencée. Il s’intéresse ensuite au rôle d’un groupement d’employeurs pour l’insertion et la qualification ( geiq ) hors Île-de-France dans la socialisation professionnelle d’apprentis comédiens. S’il constitue un « tremplin » pour leur carrière, ils restent éloignés des établissements de production parisiens et nationaux les plus légitimes, rappelant ainsi les inégalités initiales qui les avaient dirigés vers ce dispositif.
Service Innovation for Customer Engagement in the Italian Banking Sector
Authors: Formisano Vincenzo , Cavacece Ylenia , Fedele Maria , Tartaglione Andrea Moretta , Douglas Alex
Published: May 2019

The financial crisis of 2008 produced various effects on banks compelled to rethink their business models, especially for better customer relationship management following the general climate of distrust among consumers towards financial institutions. In this context, understanding how to both satisfy and engage customers has become very important. The aim of this chapter is to investigate the role of service innovation in customer engagement in the banking sector. This chapter analyzes the effects of innovative services on customer satisfaction through the study of an Italian people's bank and the application of the Kano model. The results allow identifying those services that should be improved, as they are able to increase customer satisfaction and stimulate customer engagement. For practitioners, this chapter provides evidences on how new technologies allow banks to offer high quality and personalized services through which it is possible to improve the experience of customers and their relationship with the bank.
How Smartness Enables Value Co-Creation
Authors: Ciasullo Maria Vincenza , Castellani Paola , Cosimato Silvia , Rossato Chiara
Published: May 2019

Digital revolution has involved and changed many service industries and also retailing, renewing its inbound and outbound processes. The pervasiveness of the internet of things has boosted the rise and growth of digital platforms, exploiting consumers' potential in personalizing their shopping experience, according to their wants and needs. Digital platforms have triggered the transition from a traditional two-sided marketplace towards a dynamic and complex one. The smart mindset, which has pervaded retail service domain, is in line with the current service research, according to which the dematerialization of value exchanges implies a new approach to the traditional service delivery. Therefore, this chapter aims at investigating the way retailers manage digital tools. Embracing the framework of S-D logic, the analysis shapes the role that the digital technologies have in digital process reconfiguration as well as in the shaping of specific context or platform able to boost the emergence of retail service innovation. A multiple case study has been performed.
Non-Technical Skills (NTS) Training for UAV Operators
Authors: Kille Tarryn , Bates Paul R. , Lee Seung Yong , Kille David Murray
Published: May 2019

In civilian operations, the utilization of UAVs is diverse and broad, the variations of UAVs are extensive, and the application needs and performance characteristics also vary significantly. To this end, the emerging opportunities for UAV operations have generated an urgent need for trained operators to ensure these systems are used effectively and safely. This chapter discusses the importance and integration of appropriate non-technical skills (NTS) training, particularly situation awareness (SA) and workload management, to further improve UAV mission effectiveness. The chapter explores technical design and human factors challenges impacting on UAV operations. By reviewing historical research and applicable studies in the field, the chapter also offers recommendations and solutions. While technical design solutions to UAV systems and interfaces are examined, the authors contend that specific training strategies, which focus on the human UAV operator, should also be considered.
The Use of Unmanned Aerial Vehicles
Authors: Erceg Aleksandar , Kilic Zafer
Published: May 2019

Unmanned aerial vehicles (UAVs) are present in our lives, and although they are mostly connected to military purposes, they are becoming more present in the commercial and civilian sector. Possible applications of UAVs in the commercial and civilian sector will open new possibilities for further research and development of UAVs. This movement can bring new investment and new jobs, but at the same time, it will influence the way some activities are being done now. The use of UAVs brings savings in the production cycles and improve current operations in various industrial sectors. The chapter gives a definition and explains different types and potential applications of unmanned aerial vehicles in the word as well as the potential economic impact of their development and use. In the second part, the chapter analyzes the application of drones in Turkey and Croatia. Although different in terms of their size and the number of inhabitants, both countries are at the same level in relation to UAV application. Applications in both countries are compared, and after that, a conclusion is drawn.
The Changing Face of Airmanship and Safety Culture Operating Unmanned Aircraft Systems
Authors: Lamb Tracy
Published: May 2019

The notion of using drones for commercial purposes has evolved in the past 5 years from the initial “boom” of excitement around this, somewhat of a novelty and curiosity, to more calculated and sophisticated use of unmanned aircraft systems (UAS), or drones. In the hands of true professionals, drones can offer highly efficient and profitable solutions for industrial, and commercial inspections and other data capturing tasks. The appetite for safe and efficient collection of data is a changing face of safety cultures and how teams and individuals apply airmanship principles, and how inspection crew and UAS crew interact. UAS are no longer viewed as novelty or useful addition to the inspectors' “toolbox,” but as an integrated part of safety critical system. While there is much to be learned from tradition manned aviation, UAS pilots are confronted with different task priorities in order to effectively “aviate,” and therefore, like the changing face of airmanship and safety culture, to “aviate” emerges has having different attributes when compared to manned aviation.
The Future for Civilian UAV Operations
Authors: Kille Tarryn , Bates Paul R. , Lee Seung Young , Kille David Murray
Published: May 2019

The future looks bright for unmanned aerial vehicles (UAVs). Their ability to carry sophisticated imaging equipment attached to lightweight vehicles, to hover in position despite incremental weather conditions, to fly simple missions, and takeoff and land automatically, combined with their comparatively (compared to manned aircraft) lower investment and operational costs has driven a paradigm shift in the history of air transport. This chapter is organized around six themes that underscore the current discourse regarding the future of UAVs in civilian commercial operations, as well as highlighting the discussions of the previous chapters regarding policy and certification, technology, training, social and economic forces, air cargo, and the effect of UAVs on other sectors of the air transport industry.