bluuebunny/crossref_metadata_2025 huggingface dataset:
A medicalização na escola a partir da perspectiva de professores de educação infantil: um estudo na região de Sorocaba - SP
Authors: Garcia Marcos Roberto Vieira , Borges Lenna Nascimento , Antoneli Patrícia de Paulo
Published: July 2021

O artigo parte de considerações teóricas sobre o processo de medicalização da vida, em sua interface com a instituição escola e apresenta pesquisa qualitativa feita na região de Sorocaba-SP. A pesquisa envolveu a análise de entrevistas semi-estruturadas com seis professoras de Educação infantil, com o objetivo de investigar seus discursos acerca do processo de medicalização na escola. Os resultados mostraram a percepção por parte dessas professoras da intensificação desse processo nas escolas onde trabalham e ao mesmo tempo um predomínio de apoio explícito ou implícito a ele, sendo a medicalização vista predominantemente sob um viés positivado. Eventuais problemas, como o excesso de diagnósticos ou possíveis efeitos colaterais de medicações, são apontados como fruto de diagnósticos e prescrições errados, e não como consequência do processo de medicalização em si. As famílias que resistem ao processo foram apresentadas de forma negativada, como superprotetoras ou negligentes em relação ao cuidado adequado de seus filhos. Não apareceram críticas à possível incapacidade da escola em lidar com crianças que fogem ao modelo de aluno ideal, o que mostra o processo de medicalização atrelado a um processo de disciplinarização na escola, por meio da atribuição de anormalidade aos alunos dissidentes em relação ao que é esperado.
Gamificação: modelagem de conteúdos para programas e aplicativos educativos no ambiente da TV digital interativa
Authors: Américo Marcos , Navari Shelley Costa , Belda Francisco Rolfsen
Published: July 2021

Com a implantação da TV Digital no Brasil, surge a necessidade de se fomentar a concepção e produção de conteúdos audiovisuais interativos de qualidade que apresentem mensagens educativas a partir do Edutretenimento. Este estudo propõe a aplicação da gamificação como elo comunicacional para incentivar e modificar o comportamento dos usuários, através de uma narrativa que incentive a motivação intrínseca para o entretenimento e o aprendizado nesses meios. Existem poucos modelos de roteiros para a produção de aplicativos, sobretudo educacionais, com aplicações interativas simultâneas para o fluxo televisivo ou para o conteúdo complementar da programação ofertada. Por essa razão, é atribuída uma atenção especial ao roteiro, em virtude de se inserir, em sua construção, os elementos que compõem a mecânica e a dinâmica dos jogos. Como resultado, é apresentado o verbete “Gamificação-TVDI”, bem como o desenvolvimento de uma metodologia de modelagem de conteúdo e de processo, apoiada em mapas conceituais, wireframes e roadmaps, fundamentando a concepção e a elaboração de um protótipo de roteiro com elementos de gamificação para programas educativos e seus aplicativos de interação.
Moldagem Convencional x Moldagem Digital: onde estamos e para onde vamos
Authors: Gomes Isabella Cardoso Filgueiras , Rodrigues Carlos Roberto Teixeira , Teixeira Cezar Romero Furtado , Bruno Marcelo Vieira
Published: July 2021

Uma boa moldagem é fundamental para o sucesso do processo reabilitador. O uso da técnica convencional utilizando o silicone de adição ainda se faz presente em muitos consultórios, pois é confiável e precisa. Porém com as inovações e avanços tecnológicos na odontologia, a técnica de impressão digital vem sendo aperfeiçoada há mais de 30 anos. Necessita-se saber se esta técnica atingiu os mesmos níveis de precisões e confiabilidades que a convencional. Este trabalho tem como objetivo, comparar a moldagem convencional com silicone de adição e a moldagem digital, quanto à precisão, adaptação marginal e biossegurança, assim realizou-se uma revisão de literatura utilizando as bases de dados PUBMED, SCIELO E BVS através das palavras-chave: “CAD/CAM”, “impressão convencional”, “impressão digital”, “impressão de arco total”, “silicone de adição” e “precisão”. O resultado da análise mostrou que, embora os materiais de impressão convencionais possuam ótima precisão, eles possuem algumas desvantagens, como desconforto para o paciente, causam muita sujeira, possuem várias etapas que possibilitam maior risco de causar imperfeições, e exigem uma maior experiência do profissional, enquanto as impressões digitais são mais confortáveis para os pacientes, mais ágeis e mais fáceis de usar. Ambas as técnicas de impressões digitais e convencionais demonstraram ser capazes de produzir resultados clinicamente aceitáveis, então os cirurgiões dentistas deverão basear a sua escolha de acordo com o conceito que melhor se adapta à sua prática clínica atual e o trabalho que deseja realizar.

Palavras-chaves: Técnica de Moldagem Odontológica; Tecnologia Odontológica; Precisão da Medição Dimensional; Biossegurança; CAD/CAM.
Gestão das pandemias sob a ótica da bioética principialista
Authors: Nunes Caiuze Aguiar , Bromochenkel Cattiúscia Batista , Biondo Chrisne Santana , Angelieri Gabriela Donha Yarid , Angelieri Taís Donha Yarid , Yarid Sérgio Donha
Published: July 2021

Introdução: Na última década, foram registradas duas pandemias de grande impacto em saúde pública, a causada pelo vírus Influenza A, em 2009, e pelo SARS-CoV-2, iniciada ao final de 2019. Contudo, suas implicações transpõem os limites sanitários, abarcando questões importantes concernentes aos princípios bioéticos implícitos nestes contextos. O objetivo do estudo foi refletir sobre as medidas adotadas na prevenção e contenção de pandemias, analisando-as sob a ótica da bioética principialista. Materiais e métodos: Estudo descritivo, documental, de natureza qualitativa. Resultados: Observou-se que os países adotaram medidas preventivas no modelo de educação em saúde, limitação de atividades com o distanciamento social e a vigilância dos casos diagnosticados. Considerações finais: Com o estudo, foi possível observar o engajamento de todos os países no enfrentamento das pandemias, respeitando os princípios da bioética, a exceção da justiça e da autonomia, estas restringidas por ações técnicas e governamentais, e por escassez de recursos.

Palavras-Chave: Bioética; Controle; Pandemia; Prevenção; Principialismo.
Saúde, Espiritualidade e Psicologia: o Acolher como um ato de Fé e Ciência
Authors: Santos Michelle Steiner dos
Published: July 2021

Este trabalho apresenta para um público geral algumas das concepções de ciência defendidas na modernidade refletindo como estas impactam no estabelecimento de ações voltadas a comunidade nas Instituições de Ensino Superior, sobretudo as que trazem no seu bojo constitutivo inserções sociais focadas no cuidado em saúde e sua relação com a espiritualidade. Tem-se como objetivo deste artigo informar, por meio de relato de experiência, algumas das intervenções extensionistas do Programa de Ações Integradas pela Vida (PÃIM) vinculado ao Departamento de Psicologia da Universidade Federal do Ceará e seus desafios de fazer ciência a luz dos estudos sobre espiritualidade, religiosidade, e sua busca por conectar as Práticas Clínicas em Psicologia as Práticas Integrativas e Complementares em Saúde (PICS) e, portanto, o saber científico aos saberes populares.  Através do Acolhimento Psicológico e Plantão de PICS observou-se a possibilidade de se inferir diretamente sobre algumas das questões existenciais fundantes do psiquismo e entre elas: a “fome” e o “amor”. É a fome e o amor que geram movimento, e é sobre estas categorias que se organizou no Plantão um fluxo de atendimento com base no acolhimento solidário que integrava intervenções reconhecidas pela sociedade as práticas tradicionais, unindo saúde, educação e espiritualidade. Conclui-se que para muitas das pessoas acolhidas pelo Programa, esta foi a primeira experiência integrada de práticas que lhes ajudou a reconhecer o novo e inimaginável, ou seja, uma ampliação da consciência dos problemas vividos, a percepção da fé nas próprias habilidades e a crença positiva da relação entre Psicologia, PICS e espiritualidade.

Palavras-Chave:  Acolhimento; Ciência; PICS; Espiritualidade; Psicologia; PÃIM.
Espiritualidade no enfrentamento do tratamento oncológico: revisão integrativa da literatura
Authors: Martins Joyce Santos , Cunha Juliana  Xavier Pinheiro da , Biondo Chrisne Santana , Mendes Lívia dos Santos
Published: July 2021

Objetiva-se analisar as evidências científicas sobre o exercício da espiritualidade em pacientes com câncer, tendo em vista suas contribuições para o tratamento oncológico. Realizou-se uma revisão integrativa da literatura nas bases de dados MEDLINE, LILACS, BDENF e literatura cinzenta. Foram selecionados 15 artigos em português, inglês e espanhol, publicados entre os anos de 2010 e 2020, que abordaram o papel da espiritualidade durante o tratamento oncológico. Para discussão dos resultados estabeleceu-se três categorias: (1) a espiritualidade e o bem-estar físico e emocional, (2) a espiritualidade na construção da resiliência, e (3) a espiritualidade ressignificando a vida. Notou-se que o aumento de aspectos positivos relacionados à prática espiritual como otimismo, esperança, adoção de hábitos saudáveis e redução do estresse e da ansiedade refletem no bem-estar e na qualidade de vida; o exercício espiritual oferece mecanismos para construção da resiliência, como resistência, força e superação das adversidades; e ajudam os pacientes a enxergar a vida sob uma perspectiva mais otimista. Poucos estudos abordam que não há benefícios relacionados à pratica da espiritualidade. Conclui-se, conforme a maioria das pesquisas, que a prática espiritual é relevante para o bem-estar, enfrentamento da doença e ressignificação da existência durante o tratamento oncológico.

Palavras-chave: Espiritualidade; Oncologia; Adaptação Psicológica.
Educação Permanente em Saúde Aplicada aos Técnicos no Setor de Hemoterapia de um Hemocentro Regional
Authors: Dias Milena Marques , Cordeiro Benedito Carlos
Published: July 2021

Nota prévia de uma pesquisa que tem como objetivo propor um programa de Educação Permanente em Saúde aos técnicos responsáveis pelos exames imunohematológicos do Hemocentro de Niterói, localizado do Hospital Universitário Antônio Pedro, a partir de uma investigação com abordagem metodológica qualitativa do tipo descritiva, com natureza exploratória. A pesquisa obteve parecer favorável do Comitê de Ética em Pesquisa da Universidade Federal Fluminense. A coleta de dados será realizada por meio de questionários semiestruturados. Os resultados serão analisados conforme categorização e análise de conteúdo proposta por Bardin.  Como resultado pretende-se, através da Educação Permanente em Saúde, proporcionar aos profissionais técnicos em hemoterapia novas maneiras de pensar e solucionar os problemas surgidos no cotidiano do trabalho, com a finalidade de aumentar a qualidade do serviço prestado e a segurança do paciente atendido.

Palavras-chave: Transfusão de Sangue; Serviço de Hemoterapia; Educação Continuada.
A Dimensão Afetiva e as Competências Socioemocionais na Formação do Enfermeiro: Um Estudo Sociopético
Authors: Lima Thaina Oliveira , Tavares Claudia Mara de Melo
Published: July 2021

Originado do projeto de Doutorado em Ciências do Cuidado em Saúde da Universidade Federal Fluminense. Objetivo geral: Compreender o desenvolvimento da dimensão afetiva e das competências socioemocionais através das experimentações estéticas da sociopoética. Objetivos específicos: Discutir com os graduandos de enfermagem suas vivências socioemocionais durante o curso de graduação em enfermagem, considerando o ensino teórico-prático e o estágio curricular, com enfoque na dimensão afetiva e nas competências socioemocionais; Refletir acerca do potencial de inovação da sociopoética no campo das emoções; Propor medidas para valorização da abordagem socioemocional na formação do enfermeiro; Refletir acerca das experiências emocionais dos alunos durante o período de pandemia do Coronavírus. Método: estudo sociopoético, cujos sujeitos são os alunos do 6° período do curso de enfermagem da Universidade Federal Fluminense. Produção dos dados realizada por meio do dispositivo do grupo –pesquisador através das experimentações estéticas da sociopoética. Os dados foram tratados mediante o estudo filosófico sociopoético. Resultados preliminaries: três categorias emergiram dos dados: “O ato cognoscente no processo de formação’’, ‘’A necessidade de ser um enfermeiro que irá marcar/iluminar a vida do outro’’, ‘’As dificuldades socioafetivas dos professores de graduação no ensino remoto/virtual’’. O dado mais evidente e oposto ao que se pretendia na dinâmica proposta, foi a falta de intermediação ou mesmo alusão aos vídeos apresentados (música e poesia). Os alunos apenas responderam ao tema gerador através de suas produções.

Palavras-Chave: Educação em Enfermagem; Estudantes de Enfermagem; Emoções.
Impactos do Novo Corona Vírus sobre o mercado da construção Civil
Authors: Nascimento Pedro Thaiza Maria , Braga Barbosa Barbara
Published: July 2021

A pandemia de Covid-19 surgiu em 2019, com o aparecimento de um novo vírus, com disseminação rápida e que já causou inúmeras perdas. A alta taxa de casos e de mortalidades é preocupante, levando diversos governos a estabelecerem medidas para sua contenção. Porém, essas medidas causaram consequentes impactos econômicos, pela paralização de atividades produtivas, fato que não foi diferente na construção civil. Tendo isso em mente, o presente trabalho buscou realizar um estudo sobre o panorama atual desse setor, em um cenário após o início da pandemia, bem como apontar possíveis medidas para recuperação e tendências para o futuro. Foi observado que houve uma grande queda no capital geral e muitas demissões, sendo o setor informal o mais afetado. Todavia, também se observa uma pequena recuperação, baseada no aquecimento do mercado imobiliário e de medidas tomadas pelas construtoras, como ações de responsabilidade social, digitalização dos serviços e aplicação de novos métodos, que se apresentam como principais ações de retomada. Ademais, se destaca o uso das plataformas digitais como forma de divulgação e aproximação com os clientes, além da fundamental aplicação das medidas de prevenção da doença. Conclui-se que ainda há muito desafios, mas ainda que a crise da pandemia tenha causado prejuízos, pode representar uma oportunidade de crescimento.
Exploiting Dengue Virus Protease as a Therapeutic Target: Current Status, Challenges and Future Avenues
Authors: Mushtaq Mamona , Naz Sehrish , Parang Keykavous , Ul-Haq Zaheer
Published: July 2021

Dengue, the oldest and the most prevalent mosquito-borne illness, is caused by the
dengue virus (DENV), from the family of Flaviviridae. It infects approximately 400 million
individuals per annum, with approximately half of the global population residing in high-risk
areas. The factors attributed to the geographic expansion of dengue, include urbanization,
population density, modern means of transportation, international travels, habit modification,
climate change, virus genetics, vector capacity, and poor vector control. Despite the significant
progress made in the past against dengue, no effective antiviral therapy is currently available.
Among the structural and non-structural proteins encoded by DENV genome, the
NS2B−NS3 protease complex is amongst the extensively studied targets for the development
of antiviral therapeutics owing to its multiple roles in virus life cycle. Furthermore, protease
inhibitors were found to be successful in Hepatitis C Virus (HCV) and Human Immunodeficiency
Virus (HIV). Likewise, several peptidic, peptide derived/peptidomimetic, and
small molecules inhibitors have been identified as DENV protease inhibitors. Unfortunately,
none of them have resulted in a clinically approved drug. Considering all the abovementioned
facts, this review descriptively explains the molecular mechanism and therapeutic
potential of DENV protease along with an up to date information on various competitive inhibitors
reported against DENV protease. This review might be helpful for the researchers
working in this area to understand the critical aspects of DENV protease that will help them
develop effective and novel inhibitors against DENV to protect lives of millions of people
worldwide.
A Case Report of Disseminated Histoplasmosis in AIDS Diagnosed Through Peripheral Blood Smear
Authors: Asperges Erika , Cavanna Caterina , Mollaschi Eva M.G. , Seminari Elena M.
Published: July 2021

Background:

Histoplasma capsulatum is an environmental fungus that causes opportunistic
infections in AIDS patients in endemic areas but is uncommon in Europe. It shares clinical
features with other opportunistic infections and lymphoproliferative disorders common in AIDS patients.
The World Health Organization included Histoplasma antigen tests on the Lists of Essential
In Vitro Diagnostics, however, they are not routinely available in non-endemic countries. Consequently,
mycoses can be a great challenge for clinicians in non-endemic countries.

Case presentation:

We report the case of a 42-year-old Colombian woman admitted to an Italian
university hospital with diarrhea, acute renal failure, psychomotor impairment and fever. When a
screening HIV test came back positive, she was screened for opportunistic infections with no results.
Given the severity of her clinical condition a broad spectrum antibacterial and antifungal therapy
was started in addition to HAART. A blood smear documented leucocytes inclusions, identified
as capsular structures. On suspicion of Histoplasma capsulatum the patient was started on empiric
amphotericin B. The diagnosis was confirmed by positive serology. Despite therapy, the patient
died shortly after. In the following days, the mycology laboratory managed to grow Histoplasma
capsulatum, thus confirming the diagnosis of invasive histoplasmosis in AIDS.

Conclusion:

The case highlights the need for a high index of suspicion for the diagnosis of endemic
mycosis outside of endemic areas, and the necessity of expanding access to tests. Even if antigen/
antibody tests are not available, however, blood smear has worldwide feasibility and allows a
rapid diagnosis.
Agreement Among Different Scales for Causality Assessment in Drug-Induced
Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis
Authors: Sivagourounadin Kiruthika , Rajendran Priyadharsini , Selvarajan Sandhiya , Ganesapandian Mahalakshmi
Published: July 2021

Background and Objective:

Identification of the offending drug is crucial and challenging
in cases of severe cutaneous adverse drug reactions (CADR) like Stevens-Johnson syndrome
(SJS) and toxic epidermal necrolysis (TEN). Poor reproducibility and varying levels of agreement
have been observed among different causality assessment tools (CATs) in assessing severe CADRs.
This study was conducted to examine the agreement among four different CATs in assessing
cases of drug-induced SJS, TEN and SJS/TEN overlap.

Methods:

All cases of drug-induced SJS, TEN and SJS/TEN overlap, which were reported between
January 2012 and January 2020, were identified from the ADR register at an ADR monitoring
centre. Causality assessment was done in these reported cases using the following CATs: The
World Health Organization–Uppsala Monitoring Centre (WHO–UMC) scale, Naranjo algorithm,
Liverpool algorithm and Algorithm of drug causality for epidermal necrolysis (ALDEN). Weighted
kappa (κw) test was used to evaluate the agreement among four CATs.

Results:

A total of 30 cases of drug-induced SJS, TEN and SJS/TEN overlap were included in our
analyses. The most common offending groups of drugs were anticonvulsants (46.7%), antimicrobials
(40%) and nonsteroidal anti-inflammatory drugs (13.3%). Of the anticonvulsants, phenytoin
(13.3%), carbamazepine (10%), and valproate (10%) were the commonly reported offending drugs.
Poor agreement was observed among the four different causality assessment scales.

Conclusion:

Discrepancies were observed among four different CATs in assessing drug-induced
SJS and TEN. A CAT, which is more specific to drug-induced SJS and TEN, simple, user-friendly
with limited subjective interpretation, incorporating new immunological and pharmacogenetic
markers, is necessary.
Potential Drugs for the Treatment of COVID-19: Synthesis, Brief History and Application
Authors: Uddin Ekhlass , Islam Raisul , Ashrafuzzaman  , Bitu Nur Amin , Hossain Md. Saddam , Islam ABM Nazmul , Asraf Ali , Hossen Faruk , Mohapatra Ranjan K , Kudrat-E-Zahan Md.
Published: July 2021

Coronaviruses (CoVs) belong to the Betacoronavirus group, an unusually large RNA
genome characterized by club-like spikes that project from their surface. An outbreak of a novel
coronavirus 2019 (nCOVID-19) already showed a unique replication strategy and infection that has
posed significant threat to international health and the economy around the globe. Scientists around
the world are investigating few previously used clinical drugs for the treatment of COVID-19. This
review provides synthesis and mode of action of recently investigated drugs like Chloroquine, Hydroxychloroquine,
Ivermectin, Selamectin, Remdesivir, Baricitinib, Darunavir, Favipiravir, Lopinavir/
ritonavir and Mefloquine hydrochloride that constitute an option for COVID-19 treatment.
Dipeptidyl Peptidase-4 Inhibitors and Cardiovascular Side Effects
Authors:   Medical Laboratory Technology, Poltekkes Kemenkes Maluku, Ambon, Maluku, Rizal Rizal , Suharjono Suharjono ,   Department of Clinical Pharmacy, Faculty of Pharmacy, Airlangga University, Surabaya, East Java
Published: July 2021

Aim: WHO projects that diabetes will be the seventh leading cause of death in 2030. One of the macrovascular of diabetes is cardiovascular (CV) diseases, reported incidence of heart failure in diabetic patients is twice greater than control subjects and intensive use of antidiabetic drugs in diabetic patients increase CV mortality. This review will discusses the effect of DPP4 inhibitors (DPP-4i) on CV outcomes. Data sources: PubMed 32 journals, Google Scholar 17 journals, BioMed Central 5 journals and others 1 journal Method: A systemic search of all English-language articles up to 2020 was conducted using the following terms: dipeptidyl peptidase-4 inhibitors, sitagliptin, vildagliptin, saxagliptin, linagliptin, alogliptin, gemigliptin, anagliptin, teneligliptin, alogliptin, trelagliptin, omarigliptin, cardiovascular, and mechanism on cardiovascular diseases. Results: Positive effect on CV of DPP-4i mediated by activate PI3K, CAMP, eNOS and PKA, and negative effect because their effects in modulate SP, peptide YY, and neuropeptide Y. CV outcomes of DPP-4i versus placebo are variated for MACEs, which are reported on sitagliptin HR 0.98, 95% CI 0.89 to 1.08; Vildagliptin RR 0.82, 95% CI 0.61 to 1.11; Saxagliptin HR 1.00, 95% CI, 0.89 to 1.12; Linagliptin HR 0.78, 95% CI, 0.55 to 1.12; Alogliptin HR 0.85, CI 95%, 0.66 to 1.10; and Omarigliptin HR=0.85, CI 95%, 0.66-1.10. Conclusion: Based on the mechanism DPP-4i inhibitors have either cardioprotective actions or poorer outcomes on CV because their activities are connected with the inhibition of various substrates. DPP-4i sitagliptin, vildagliptin, saxagliptin, linagliptin, alogliptin, and omarigliptin did not significantly increase of MACE (major adverse cardiac events).
Ekspresi Glukosa Transporter-2 di Sel Beta Pankreas dan Sel Hepatosit Tikus yang Diinduksi Diabetes Mellitus
Authors:   Farmasi, Fakultas Farmasi, Institut Sains dan Teknologi Nasional, Jakarta Selatan, Indonesia, Teodhora Teodhora , Yuliana Depi ,   Farmasi, Fakultas Kesehatan, Universitas Qamarul Huda Badaruddin, Nusa Tenggara Barat, Indonesia, Adhiguna Toding Ficanata ,   3Farmasi, Fakultas Farmasi, Akademi Farmasi Tadulako Farma, Sulawesi Tengah, Indonesia
Published: July 2021

Diabetes Mellitus (DM) is an incurable disease that can be prevented clinically from worsening. This disease is based on classification related to pancreatic damage in total or partial so that the impact on insulin production. Glucose transporter is a protein that can glucose uptake from outside cell into cell and provides an important role in the body's glucose homeostasis. Glucose transporter-2 (GLUT-2) is found in the pancreas, liver, and kidney. Parameters used are the expression and amount of GLUT-2 density in pancreatic β cells and in hepatocyte cells in normal and diabetic Rat. Used Wistar strain male white rats. An immunohistochemistry (IHC) staining technique was performed to observe the expression of GLUT-2 and the macbiophotonics image J program to determine total density of GLUT-2. GLUT-2 is marked in brown in the cell nucleus surrounded by cytoplasm. The results showed an increased in GLUT-2 expression in hepatocyte cells with a total density of 25,447,052 and a decreased in GLUT-2 expression in pancreatic β cells with a total density of 5,074,544 by Streptozotocin 50 mg/kg BB-Nicotinamide 100 mg/kg BB (STZ-NA) Intraperitonial routes in induced DM rat. STZ-NA induced triggers damage in pancreatic β cells and significantly influences the expression of GLUT-2 protein. High blood glucose levels give different GLUT-2 activity in hepatocyte cells due to the effects of induced agent.
ANALISIS RETORIKA VISUAL PADA KONTEN YOUTUBE KANAL SKINNYINDONESIAN24 DENGAN JUDUL “YOUTUBE LEBIH DARI TV”
Authors: Aini Syarifah Nur , A'yun Bintan Auliya Qurrota , Pradipta Eugenius Damar , Akalili Awanis , Kulau Febriansyah
Published: July 2021

Saat ini media semakin mengalami degradasi moral salah satunya yaitu praktik monopoli media dan monetisasi pada beberapa media social. YouTube merupakan media baru yang menjadi contoh dari praktik monopoli dan monetisasi media. Tujuan dari penelitian ini adalah untuk menganalisis dan mendeskripsikan pesan menggunakan retorika visual yang ditampilkan pada kanal YouTube milik SkinnyIndonesian24 dengan judul “YouTube Lebih dari TV”. Fokus pada penelitian ini adalah pesan yang disampaikan oleh youtubers SkinnyIndonesian24 melalui video yang dibuatnya dengan menggunakan retorika visual pada beberapa shot (visualisasi) dan juga audio . Teori yang digunakan dalam penelitian ini adalah Teori Retorika visual Sonja K. Foss dan menggunakan analisis segitiga retorik Hesford & Bruggemann serta teknik sinematografi. Metode penelitian yang digunakan adalah metode kualitatif. Hasil penelitian ini adalah dalam setiap shot pada video “YouTube Lebih dari Tv” menarasikan adanya fenomena sosial mengenai monopoli media di YouTube. Dengan adanya penelitian ini diharapkan mampu memberikan informasi dan membuka wawasan pada masyarakat luas.
ANALISIS TEKNIK DIGITAL MARKETING PADA APLIKASI TIKTOK (Studi Kasus Akun TikTok @jogjafoodhunterofficial)
Authors: Priatama Ryan , Ramadhan Ilham Hilal , Zuhaida Az- , Akalili Awanis , Kulau Febriansyah
Published: July 2021

Diunduh lebih dari 2 Miliyar per tiga bulan pertama di tahun 2020, menjadikan Tiktok sebagai salah satu platform digital marketing yang banyak digunakan masyarakat. Aplikasi Tiktok hadir di Indonesia banyak dimanfaatkan untuk berkreativitas hingga berbisnis oleh masyarakat. Salah satu akun Tiktok yang aktif dalam menggunakan aplikasi ini sebagai digital marketing adalah @jogjafoodhunterofficial dengan jumlah pengikutnya sebesar 549,7 ribu. Digital marketing merupakan penerapan teknologi digital untuk menciptkan saluran yang dapat berhubungan dengan konsumen potensial agar tujuan pelaku usaha dapat berjalan secara efektif. Tujuan penelitian ini adalah untuk mengetahui teknik digital marketing yang digunakan oleh akun Tiktok @jogjafoodhunterofficial. Metode penelitian yang digunakan adalah kualitatif dengan metodologi yang dipakai yakni studi kasus. Hasil penelitian yang peneliti dapatkan menunjukan bahwa akun Tiktok @jogjafoodhunterofficial menggunakan beberapa teknik digital marketing, yaitu iklan, story telling, komedi, diskon, testimoni, tagar, dan promo, serta ditemukan beberapa temuan teknik baru yang belum ada di penelitian terdahulu seperti audio musik, feedback, dan cashback. Manfaat penelitian ini adalah untuk menambah wawasan dan penegatahuan serta memberi informasi dan alternatif digital marketing melalui aplikasi Tiktok.
Interpretation of Dear Me Beauty Product Rebranding: Twitter Users Analysis
Authors: Sihombing Lambok Hermanto
Published: July 2021

This study aimed to discuss the way Dear Me Beauty was rebranding their brand by launching new products after they have a brand crisis. The data of this research was obtained from the comment of a Twitter user. This study used the encoding decoding theory from Stuart Hall. The findings of this study was the response from Twitter users was positive, implying that Dear Me Beauty's rebranding was successful. The researchers discovered that the messages from Dear Me Beauty conveyed through their newest product could be well interpreted and accepted by the public.
LEVELS OF HOMOCYSTEINE AND BLOOD CHOLESTEROL AND ANDROGENESTROGEN BALANCE IN MEN WITH IDIOPATHIC PATHOSPERMIA
Authors: Bondarenko V. A. , Minukhin A. S. , Skornyakov E. I.
Published: July 2021

It were studied the levels of sex hormones, homocysteine and cholesterol levels in 46 men with pathospermia aged 22–45 and 11 healthy men of the same age. It was found that men with idiopathic infertility observed increase in homocysteine level in the blood, which does not depend on the level of estradiol and values of testosterone-estradiol ratio. It was shown that hyperhomocysteinemia is an independent factor that exacerbates the violation of spermatogenesis in men with idiopathic pathospermia. It was a positive correlation between the levels of cholesterol and homocysteine as in healthy and in infertility men. It was found that the decrease in the quantities of testosteroneestradiol ratio is a predictor of hypercholesterolemia in the formation of blood, which adversely affects spermatogenesis in men with idiopathic pathospermia.
CHANGES IN HISTOSTRUCTURE AND LEPTIN PRODUCING IN ADIPOSE TISSUE DURING LIGHT-INDUCED HYPOPINEALISM
Authors: Sergiyenko L. Yu. , Bondarenko L. A. , Gevorkyan A. R. , Sotnik N. N. , Cherevko A. N. , Mishchenko T. V.
Published: July 2021

In the literature of recent years it was widely discussed the issue of violation of the light mode as a risk factor for the formation of obesity — one of the leading symptoms of metabolic syndrome and type 2 diabetes. However, until the real time, the effect of the long round-the-clock illumination of different duration on histological and leptinproducing activity of adipose tissue remains unclear. Studies of the dynamics of weight indicators, histological characteristics and the level of leptin in the blood plasma of rats subjected to long round-the-clock illumination, for 3, 5 and 10 months, led to the conclusion that, originally, animals subjected to long round-the-clock illumination observed an activation of hyperplastic processes in adipose tissue and increasing of its leptinsynthesizing activity. Long round-the-clock illumination as an inducer of expressed hypopinealizm is the cause hypoplasia of adipose tissue, a sharp drop of its cytokineproducing function and the development of its nonspecific inflammation.
FEATURES OF OSTEOPOROTIC CHANGES AT THE REPRODUCTIVE AGE FEMALES WITH DIFFUSE TOXIC GOITER (literature review and own data)
Authors: Gerasimenko L. V.
Published: July 2021

It was shown the modern data on the study of the risk factors which contribute to the formation of osseous tissue structural and functional disorders at the diffuse toxic goiter (DTG) patients and evaluation of the bone tissue metabolism. At the surveyed reproductive age women with DTG the bone disorders set up to 57.47 % (osteopenia — 54 %, osteoporosis — 46 %). As the result of the research it was proved the necessity of densitomertic examination for DTG patients, especially T-point determination which indicates early character of osteoporotic disorders at DTG.
THEORETICAL JUSTIFICATION OF SEARCH OF NEW WAYS OF AUTOIMMUNE THYROIDITIS TREATMENT
Authors: Malova N. G. , Sirotenko L. A.
Published: July 2021

The review of scientific literature on a condition of treatment a problem of an autoimmune thyroiditis is submitted. Modern views on the emergence mechanism of appearance, diagnostic markers and ways of therapy of this disease are considered. The analysis of the available methods of treatment and experimental researches are carried out. Rather perspective, for studying in this direction, preparations of a fetal placental complex are represented.
THE PREDICTIVE VALUES OF DESMOPLASTIC FIBROSIS AND THE MATURITY OF CONNECTIVE TISSUE COMPONENT OF PAPILLARY THYROID MICROCARCINOMAS
Authors: Yakovtsova I. I. , Ivakhno I. V. , Arsenyev A. V. , Sokolova S. S. , Perepiolkina S. V.
Published: July 2021

Based on examination of the stroma 181 papillary thyroid icrocarcinomas and detection the relationship with the stage of the disease using the NM system, it was discovered that desmoplasia and stroma maturity are important prognostic criteria. Lack desmoplasia, mature and mature mixed stroma associated with stage I, severe desmoplasia and immature type of stroma — with stage III, the mixed immature type — with stage IV disease.
CARBOHYDRATE EXCHANGE IMPACT ON EXTRACELLULAR MATRIX IN PATIENTS WITH ACUTE MYOCARIAL INFARCTION AND TYPE 2 DIABETES MELLITUS
Authors: Koteliukh M. Yu.
Published: July 2021

The study involved examination of 60 patients with acute myocardial infarction and type 2 diabetes mellitus, 40 patients with acute myocardial infarction and without type 2 diabetes mellitus and 20 substantially healthy subjects. The research allowed the authors to evaluate the effect of carbohydrate metabolism on extracellular matrix components in patients with acute myocardial infarction with the presence or absence of type 2 diabetes mellitus. The correlation relationship in patients with acute myocardial infarction and type 2 diabetes mellitus was found to be as follows: between matrix metalloproteinase-13 on the 1st–2nd day and glucose (r = 0.36; p < 0.05), glycosylated hemoglobin (r = 0.42; p < 0.05); tissue inhibitor of metalloproteinase-4 and glucose (r = 0.22; p < 0.05); tenascin C and glycosylated hemoglobin (r = –0.28; p < 0.05), glucose (r = –0.24; p < 0.05).
THE INFLUENCE OF GADOLINIUM ORTOVANADATE AND CERIUM DIOXIDE NANOPARTICLES ON SPERMOGRAM OF ADULT MALE RATS WITH NEONATAL INDUCED DISORDERS OF REPRODUCTIVE FUNCTION
Authors: Koreneva E. M. , Karpenko N. A. , Smolenko N. P. , Belkina I. O. , Chistyakova E. Ye. , Selyukova N. Yu. , Karachentsev Yu. I. , Klochkov V. K. , Yefimova S. L. , Kavok N. S.
Published: July 2021

It was investigated the influence of nanoparticles SeO2 and GdVO4 on spermogram of adult male rats with an experimental violation of reproductive function. The adult male rats that were under emotional stress and excess intake of phytoestrogens during milk suckling were given nanoparticles SeO2 or GdVO4 with feed during 70 days. The increase of sperm concentration and the number of their normal forms, improving functional characteristics were found in both cases. The nanoparticles that was investigated, are promising compounds to restore neonatal impaired reproductive function.
«TART-TUMOR» IN ADULTS PATIENTS WITH CONGENITAL DYSFUNCTION OF ADRENAL CORTEX
Authors: Polozova L. G. , Bondarenko V. A. , Popova S. S.
Published: July 2021

According to publications in the foreign literature, the incidence of secondary testicular structuresin the patients with congenital adrenal cortical dysfunction (CACD) amounts to 90 %. In Ukraine, thescheduled screening for TART tumours in the male patients presenting with CACD is not carried out.At the same time, the late consequences of this pathology (infertility, obstructive testicular diseases)require increasingly more attention starting from the early childhood.
PROGNOSTIC VALUE OF ARTERIAL STIFFNESS PARAMETERS CHANGES IN CARDIOVASCULAR DISEASES DEVELOPMENT BY DIABETES MELLITUS (literature review)
Authors: Serhiyenko V. A. , Serhiyenko A. A.
Published: July 2021

This review presents actual data about the diagnostic methods and value of the arterial stiffness parameters changes by cardiovascular diseases (CVD), diabetes mellitus, diabetic cardiovascular autonomic neuropathy, in particular, including results of non-invasive arteriographic determination of pulse wave velocity, ambulatory aortic stiffness index, aortic and brachial augmentation indices. Results of the analysis indicate that increased arterial stiffness is considered as a non-invasive marker of subclinical atherosclerosis and may be integral indicator of cardiovascular risk, independent predictor of CVD and mortality, while normalization of increased vascular wall rigidity — an important criterion for the effectiveness of therapy.
Modeling of chronic prostatitis. Abacterial prostatitis in the aspects of reproduction of experimental hypofertility (review)
Authors: Koreneva E. , Philimonova N. , Brechka N. , Chistyakova E. , Smolyenko N. , Belkina I. , Karpenko N.
Published: July 2021

There is a problem of modeling of prostatitis in animals despite of the progress at the creation of prostatic protectors capable of correcting hypofertility. In this regard, modeling prostate gland pathology, monitoring its development and finding out factors causing a decrease in the generative function in prostatitis are topical issues. In this review, the important role of experimental modeling of prostatitis have been shown, the etiology, pathogenesis and clinical manifestations of prostatitis, the epidemiology of reproductive impairment in conditions of abacterial inflammatory process of the prostate gland have been reviewed, and data about methods of prostatitis modelling in laboratory animals. Such modeling of chronic abacterial prostatitis in rats has been reviewed: by rectal administration of dimexide and turpentine; by cryotrauma; piercing (traumatic) prostatitis; prostatitis after hypokinetic stress; autoimmune prostatitis; acute aseptic inflammation of the prostate gland; chronic prostatitis by applying metaxylene; as well as experimental models of prostatitis associated with hormonal effects. Summarizing the literature data, the authors conclude that the experimental modeling of chronic prostatitis is an issue of importance not only for the study of the course of this common disease, but also for the development of new methods and measures for the treatment of prostatitis and reproductive health disorders that occur on the background or accompanied by inflammation.
THE ROLE OF CLUSTERIN IN THE DEVELOPMENT OF DIABETIC MACULAR EDEMA IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: Kyryliuk M. L. , Suk S. А. , Rykov S. O. , Mogilevskyy S. Yu.
Published: July 2021

Relevance. One of the main causes of visual impairment in patients with type 2 diabetes mellitus (DMT2) is diabetic macular edema (DME). Complications associated with DME include microglial activation, dysfunc tion of neurons, their dystrophy and apoptosis. Purpose. To study the peculiarities of the content of anti-apoptotic factor clusterin in serum and to analyze the relationship of clusterin with the state of the macula in patients with DMT2 and DME. Material and research methods. 82 patients with DMT2 (145 eyes) were divided into 4 groups according to the form of DME. The criteria for inclusion in the open study was voluntary informed consent, age 18 years, the presence of DMT2. Non-inclusion criteria were the presence of endocrine diseases, which can lead to type 2 diabetes, DMT1, acute infectious diseases, cancer, decompensation of comorbid pathology, mental disorders, antipsychotics, antidepressants, neurodegenerative diseases of the central nervous system, proteinuria, damage to the optic nerve, glaucoma and mature cataracts. The following instrumental indices were used for the study: nerve fiber layer thickness — NFL, ganglion cell layer thickness — GCL, inner posterior layer thickness — IPL, central retinal thickness, the volume of the macula and central fovea, the minimum thickness of the central fovea (minimum in fovea), the average thickness of the retina in the macula (area thickness). Results. By en determined that in patients with T2DM and DME, chances of oc currence of low thickness (value > QI) of NFL + GCL + IPL (> 115 .m) and NFL (> 31 .m) are significantly in creased with increasing the blood clusterin levels on each 1 .g/ml (OR = 1.04 (95 % CI 1.01–1.08) and OR = 1.04 (95 % CI 1.01–1.08), respectively). It was shown that the optimal threshold value for serum clusterin is 77.0 .g/ml. With a selected clusterin content threshold for NFL + GCL + IPL thickness > 115 .m, the test sensitivity is 59.6 %, specificity is 75 %, and for NFL thickness > 31 .m — 56.7 % and 76.2 %, respectively. Conclusion. An increasing of the concentration of blood plasma clusterin over the optimal threshold (that we have identified) can be an indicator of the active inflammatory process and edema of the retina.
DIAGNOSIS OF THE CARDIAC AUTONOMIC NEUROPATHY IN DIABETIC PATIENT
Authors: Shuper V. A. , Shuper S. V. , Rykova Ju. O. , Trefanenko I. V. , Shumko G. I. , Reva T. V.
Published: July 2021

Cardiac autonomic neuropathy (CAN) is a very common diabetes-related complication that has a major effect on CVD, mortality and morbidity in patients with DM. Careful and timely testing of CAN with easy standard bedside tests in patients with DM 1 and 2 is critically important for early diagnoses and prophylaxes of further CV complications. Aim of the study was to evaluate the CAN characteristics in DM 1 versus DM 2 patients and to identify the relationship between CAN and typical diabetic complications. Materials and methods. A descriptive and comparative cross-sectional study was developed with 75 patients with Diabetes Mellitus (DM 1 — 30 patients, DM 2 — 45 patients) who were hospitalized to the endocrinology department for treatment. All patients were investigated routinely – complains, anamnestic data, objective examination, lab and instrumental examination. For defining of CAN next five classical tests were done (cardiac autonomic reflex testing (CART)): Evaluating of the Resting tachycardia; Heart rate response to deep breathing; Valsalva maneuver; Systolic blood pressure response to standing; Diastolic blood pressure response to sustained handgrip. Results and discussions. Absence of CAN, according to proposed score, was defined in those patients without clinical features of CVD. 46.8% of all patients presented with early and definitive CAN, while the higher prevalence of definitive CAN was diagnosed in DM 2 patients. Severe CAN was confirmed more often in DM 2 patients also. Coexistence of CAN and peripheral neuropathy was higher in patients with DM 1 than in DM 2 patients. Among DM 1 patients with CAN only 11.8% persons had not sensory peripheral neuropathy, while 29.7% DM 2 patients with CAN, were free of sensory peripheral neuropathy. Positive correlations were found between the duration of the DM and manifestations of CAN in patients with DM II, the development of sensory polyneuropathy, retinopathy and CAN in patients with DM I, and this diabetic complication preceded the clinical manifestations of peripheral neuropathy. Thus, the proposed set of diagnostic measures should be obviously and easily used for the timely diagnosis of CAN in diabetic patients, especially in asymptomatic cases, and objectively assessing the effectiveness of the therapy.
THE VALUE OF THE TUMOR NECROSIS FACTOR-ALPHA AND VASPIN RATIO IN THE DEVELOPMENT OF INSULIN RESISTANCE
Authors: Zhuravlyova L. V. , Pylov D. I.
Published: July 2021

Diabetes mellitus type 2 is a chronic disease that results in metabolic disorders in the whole organism, primarily due to insulin resistance and relative insufficiency of insulin. The fatty tissue is no longer considered only as a passive depositary for the accumulation of energy and participation in the regulation of thermogenesis. In the last decades, it has been noted that this is an active endocrine organ that in addition to regulation of fat mass and participating in homeostasis, also releases a large number of bioactive mediators called adipokines. Adipokines are influenced by an autocrine or paracrine method on a variety of metabolic processes. Increased body weight is a factor in the development of different metabolic disorders. Excess fatty tissue can directly affect one of the main metabolic links — activity and insulin sensitivity. Increased body weight is a factor in the development of a carbohydrate metabolism disorder. Vaspin is an adipocytokine, a representative of widely spread serpins (serine protease inhibitors). The elevated serum protease inhibitor profile was noted in overweight and insulin-resistant mice. It is suggested that vaspin is an insulin sensitizer with anti-inflammatory action and can take part as a compensatory mechanism in response to reduced insulin sensitivity. Therefore, the activation of vaspin may decrease insulin resistance. Evaluation of protease which can be inhibited by vaspin may increase the development of new approaches of compensation based on etiology of impaired metabolic and glucose tolerance. The tumor necrosis factor-α (TNF-α) is a cytokine that is involved in systemic inflammation. The elevated levels of TNF-α are considered as one of the causative factors in insulin resistance, which is associated with obesity in the pathogenesis of DM-2. This review article provides an analysis of mostly foreign scientific articles about the importance of adipokines, particularly TNF-α and vaspin, in the development of insulin resistance and the possibility of further consideration of these markers as an indicator of the severity of the impaired carbohydrate metabolism.
Predicting the Linguistic Accessibility of Chinese Health Translations: Machine Learning Algorithm Development
Authors: Ji Meng , Bouillon Pierrette
Published: July 2021

Background

Linguistic accessibility has an important impact on the reception and utilization of translated health resources among multicultural and multilingual populations. Linguistic understandability of health translation has been understudied.

Objective

Our study aimed to develop novel machine learning models for the study of the linguistic accessibility of health translations comparing Chinese translations of the World Health Organization health materials with original Chinese health resources developed by the Chinese health authorities.

Methods

Using natural language processing tools for the assessment of the readability of Chinese materials, we explored and compared the readability of Chinese health translations from the World Health Organization with original Chinese materials from the China Center for Disease Control and Prevention.

Results

A pairwise adjusted t test showed that the following 3 new machine learning models achieved statistically significant improvement over the baseline logistic regression in terms of area under the curve: C5.0 decision tree (95% CI –0.249 to –0.152; P<0.001), random forest (95% CI 0.139-0.239; P<0.001) and extreme gradient boosting tree (95% CI 0.099-0.193; P<0.001). There was, however, no significant difference between C5.0 decision tree and random forest (P=0.513). The extreme gradient boosting tree was the best model, achieving statistically significant improvement over the C5.0 model (P=0.003) and the random forest model (P=0.006) at an adjusted Bonferroni P value at 0.008.

Conclusions

The development of machine learning algorithms significantly improved the accuracy and reliability of current approaches to the evaluation of the linguistic accessibility of Chinese health information, especially Chinese health translations in relation to original health resources. Although the new algorithms developed were based on Chinese health resources, they can be adapted for other languages to advance current research in accessible health translation, communication, and promotion.