bluuebunny/crossref_metadata_2025 huggingface dataset:
Design of College Scheduling Algorithm Based on Improved Genetic Ant Colony Hybrid Optimization
Authors: Li Ting , Xie Qiang , Zhang Hua
Published: June 2022

With the gradual expansion of college scale, the professional categories in colleges and universities are becoming more and more complete, and the volume of courses is becoming more and more huge. In the meantime, the number of students is growing by leaps and bounds, and the teaching resources are subject to more and more complicated teaching tasks. The workload and the difficulty of scheduling in teaching management are also on the rise year by year. This paper proposes a design of a college scheduling algorithm based on an improved genetic ant colony hybrid optimization algorithm. Firstly, the fitness-enhanced elimination law is proposed to improve the selection process of traditional genetic algorithms. Subsequently, the gene infection crossover method is proposed to ensure the increase of the average fitness value in the evolutionary process. Next, the unnecessary replication operation in the traditional genetic algorithm is removed to enhance the operation speed of the algorithm. Finally, the parallel mechanism of fuzzy adaptive is introduced to improve the convergence and stability of the algorithm. For the ant colony optimization algorithm, a nonuniform pheromone distribution is used according to the position of the current raster relative to the starting point, which makes the initial pheromone concentration of the dominant raster higher and avoids blind search by ants. The ant movement rules are redefined by the directional neighborhood expansion strategy to further shorten the path. The experimental results indicate that the hybrid optimization algorithm outperforms other algorithms in terms of performance in terms of scheduling success and scheduling time, and it can be applied in practical scheduling because of the high quality of courses schedule.
[Retracted] Magnetic Resonance Imaging Features in Diagnosis of Breast Cancer and Evaluation of Effect of Epidermal Growth Factor Receptor‐Targeted Therapy
Authors: Yang Hao Hao , Zhang Fang Fang
Published: June 2022

Breast cancer diagnosis and treatment are important healthcare issues in the Industrialized World. In this study, magnetic resonance imaging (MRI) images are used to diagnose breast cancer (BC) and analyze the application effect of epidermal factor receptor‐targeted therapy in the treatment of BC. A total of 858 patients diagnosed with BC in Jincheng People’s Hospital from 2019 to 2021 are included and randomly divided into an experimental group and a control group. The experimental group is treated with epidermal growth factor receptor‐ (EGFR‐) targeted therapy, and the control group is treated with conventional chemotherapy according to subsequent treatment modalities. Experimental results show that compared with manual segmentation, machine automatic segmentation includes the local and edge information of the image with higher accuracy, compared with benign and malignant tumors. There are significant differences in the changes of Tpeak, SSmax, El, E2, and E5, P < 0.05, with SSmax and El having the greatest changes. After chemotherapy, the recorded maximum diameter of cancer foci in the control and the experimental groups are 26.4 ± 11.6 mm and 20.3 ± 13.5 mm, respectively, and the difference is statistically meaningful (P < 0.05). The ADC value (12.74 ± 2.08) in the experimental group is higher than that (9.7 ± 1.88) in the control group (P < 0.05). There is a significant difference in SSmax between the control group and experimental group (P < 0.05), the SImax, pH values of the control group are significantly higher than those of the experimental group (P < 0.05), and the SSmaxR value (7.82 ± 6.24) in the experimental group is lower than that in the control group (10.08 ± 6.25), but the difference is not significant, P > 0.05. The proposed MRI method has high sensitivity and accuracy in the diagnosis of BC, improving the detection rate of lesions, compared with conventional chemotherapy. In addition, epidermal factor receptor‐targeted therapy has a better therapeutic effect, with significant changes in cancer foci, which has the value of clinical promotion.
The Diagnostic Performance of 18F-FDG PET/CT in Recurrent Pancreatic Cancer: A Systematic Review and Meta-analysis
Authors: A Gu , Shan Yuezhan , Huo Huasong , Ding Chao , Sun Caixia
Published: June 2022

Purpose. The CT scan is the best common screening test for pancreatic cancer recurrence after surgery. The goal of our meta-analysis was to assess the diagnostic accuracy of 18F-FDG PET/CT for pancreatic cancer recurrence. Methods. We examined PubMed and Embase for suitable papers between 2009 and 2022. The researchers considered studies that looked at the diagnostic usefulness of 18F-FDG PET/CT in identifying local and/or distant disease recurrence throughout the follow-up following pancreatic cancer resection. The Quality Assessment of Diagnostic Performance Studies-2 (QUADAS-2) method was used to evaluate the quality of each study. For each of the publications included, two researchers extracted data independently. The extracted data included general data (authors, year of publication), literature characteristics (country, type of literature, and design of study), characteristics of the patient (patients’ number, mean or median age, and treatment regimen), and technical aspects (scanner, injection activity, and image analysis). Results. The analysis includes 7 trials with a total of 263 patients. The sensitivity and specificity of 18F-FDG PET/CT in detecting recurrent pancreatic cancer following definitive treatment were 0.89 (95 percent CI: 0.83-0.93) and 0.88 (95 percent CI: 0.72-0.96), respectively, according to the pooled estimates. PET/CT performed well in the diagnosis of recurrent pancreatic cancer, with an AUC of 0.94. (0.91-0.95). Conclusions. 18F-FDG PET-CT was found to be a reliable detection method in recurrent pancreatic tumor.
TOPK Affects Autophagy of Skin Squamous Cell Carcinoma by Regulating NF-KB Pathway through HDAC1
Authors: Li Juan , Zhang Zhi-chao , Yuan Xiang-shi , Tang Shan-shan , Wang Tao , Liu Hong-fu , Cao Yu
Published: June 2022

Objective. To explore the effect and potential mechanism of T-LAK cell-originated protein kinase (TOPK) on autophagy in cutaneous squamous cell carcinoma (cSCC). Methods. Human cSCC cancer tissue and paracancerous tissue samples were collected clinically; immunohistochemistry was used to detect the expression of TOPK, nuclear factor κB p65 (NF-κB p65), phosphorylated nuclear factor κB inhibitor α (p-IκBα), Beclin-1, and microtubule-associated protein 1 light chain 3 (LC3) in cSCC tissue; and immunofluorescence was adopted to detect the coexpression of NF-κB p65, p-IκBα, and TOPK in cSCC tissue. After TOPK silencing or overexpression, SCL-1 and A431 cells were treated with PDTC and 3-MA, respectively. RT-qPCR and Western Blot were used to detect the mRNA and protein expressions of histone deacetylase 1 (HDAC1) in TOPK-silenced/overexpressing cells. Western Blot was performed to detect the protein expressions of NF-κB p65, p-p65, IκBα, p-IκBα, Beclin-1, and LC3 in each group. Transwell and scratch healing experiments were used to detect the ability of cells to invade and migrate. The formation of autophagosomes in each group was observed by TEM. Results. Compared with adjacent tissues, TOPK, NF-κB p65, p-IκBα, Beclin-1, and LC3 were highly expressed in cSCC cancer tissues; TOPK and NF-κB p65 were coexpressed; and TOPK and p-IκBα were expressed in cSCC cancer tissues both increased. The mRNA and protein levels of TOPK in human cSCC cells were significantly higher than those in human normal skin HaCaT cells. After TOPK knockout, the expression of HDAC1, p-IκBα/IκBα, NF-κB p65, p-p65, Beclin-1, LC3II/I proteins, cell invasion, and migration abilities were significantly reduced, and fewer autophagosomes were observed. Treatment with PDTC and 3-MA significantly downregulated NF-κB pathway protein activity and autophagy level and reduced cell migration and invasion ability. Conclusion. TOPK promotes the malignant progression of cSCC by upregulating HDAC1 to activate the NF-κB pathway and promote autophagy.
Analysis of Digital Photography Technology in the Era of Big Data
Authors: Lu Yifeng , Liu Sihua , Bai Yunting
Published: June 2022

The term “Digital Photography” has been a relatively new research topic in the field of computer-mediated technology. Although Digital Photography emerged thirty years ago, continuous developments and upgradations are being recorded frequently. Advanced technologies like Digital Technology transformed all the technology into digital mode. The field of photography underwent several developments in terms of camera quality, image quality, image clarity, image transfer, image storage, and other sensitive surfaces. Most of the studies confirmed that digital photography permitted the photographer to record videos at high resolutions. All the developments in the field of Digital Photography have largely contributed to the concept of modern photography and enabled the photographers to produce high-quality images. It also helped photographers enhance their photography skills and accomplish their tasks. All the transformations in the field of Digital Technology happened at a pace, and it was extremely difficult. Therefore, the current paper sheds light on the developmental stages of digital photography. It also highlights the significance of digital photography technology in the era of big data.
Contemporary Value Assessment of Marxist Ideology under the Context of Deep Learning
Authors: Sun Jian
Published: June 2022

As a conceptual superstructure, ideology plays a very important role in national security, social stability, and healthy economic development. As a result, ideological work is critical to the Party’s success, and the current focus of ideological work is to increase ideological risk prevention. The focus of ideological risk avoidance is gradually shifting to cyberspace as the Internet becomes the primary arena and forum for information interchange, value dissemination, and ideological exchanges. Deep learning, as a data processing technology, is characterized by deep data analysis and full generalization and can have an impact on ideological security work: on the one hand, it helps work subjects evaluate and count the process and effect of work in order to grasp the trend of public opinion; on the other hand, it helps work subjects understand and reflect on the inner logic and contemporary value of Marxist theory through diversified work platforms and diverse work methods and promotes work subjects’ understanding of Marxist theory. On the other hand, through diversified working platforms and various working methods, we help the working targets to understand and reflect on the inner logic and contemporary values of Marxist theory and promote their true identification with socialist core values. Based on the impact of deep learning on work subjects and work objects, this paper proposes that Marxian ideological security workers can use it to effectively achieve good communication and contemporary value assessment among different work subjects, set specific indicators according to the division of labour, adopt different working methods according to the groups to which the learning bjects belong, and establish a long-term evaluation mechanism in the process.
Radiological Cardiothoracic Ratio as a Potential Marker of Left Ventricular Hypertrophy Assessed by Echocardiography
Authors: Truszkiewicz Krystian , Macek Piotr , Poręba Małgorzata , Poręba Rafał , Gać Paweł
Published: June 2022

The aim of the study was to verify the usefulness of the radiological cardiothoracic ratio as a potential marker of left ventricular hypertrophy assessed by echocardiography. The study included 96 patients (mean age: 49.52 ± 9.64 years). Chest radiograph in the PA projection and echocardiography were performed. In CR the measurement of the cardiothoracic ratio (CTR) was performed. Assuming CTR > 0.50, heart silhouette enlargement was diagnosed. In echocardiography, four types of left ventricular geometry were assessed: normal geometry (NG), concentric remodeling (CR), concentric hypertrophy (CH), and eccentric hypertrophy (EH). It was shown that patients with an enlarged heart silhouette were characterized by a significantly more frequent occurrence of left ventricular hypertrophy (LVH) on echocardiography than patients with a nonenlarged heart silhouette. In the subgroup of patients with LVH compared to the subgroup of patients with normal left ventricular geometry, CTR values are statistically significantly higher, and heart silhouette enlargement is significantly more frequent. The criterion “CTR > 0.49” estimates LVH with a sensitivity of 93.3% and specificity of 82.7%, which translates into a high accuracy of 84.4%. By analyzing the prediction of left ventricular geometry types, high accuracy of CH prediction was obtained using the “CTR > 0.49” criterion of 80.2% (with a high sensitivity of 84.0% and a satisfactory specificity of 60.0%) and a high accuracy of EH prediction using the “CTR > 0.52” criterion of 71.9% (with high sensitivity 80.5% and low specificity 36.8%), as well as low CR prediction accuracy of only 57.3% (with low sensitivity 36.7%, even if high specificity 78.7%). In summary, the radiological cardiothoracic ratio may be a moderate marker of left ventricular hypertrophy assessed according to standard echocardiographic criteria, provided that its cut-off point is standardized in each population of subjects.
Effect of Hematocrit Injury on the Survival Rate of Advanced Malignant Tumors and Its Clinical Significance
Authors: Li Lin , Wu Weibin , Yin Mingdi
Published: June 2022

Objective. To investigate the effect of logistic multivariate analysis on the survival rate of advanced malignant tumors and to evaluate the effect of erythrocyte storage injury on the survival rate of advanced malignant tumors and its clinical significance. Methods. A retrospective analysis was performed on 120 advanced cancer patients who received blood transfusion in Shaanxi Cancer Hospital from March 2018 to June 2019, and the risk factors for death were analyzed. A total of 72 advanced cancer patients admitted to hospital from March 2019 to June 2021 were included in the study. The patients with red blood cell transfusion storage

time
≤
14

 d were the study group (

n
=
36

), and the patients with red blood cell transfusion storage

time
>
14

 d were the control group (

n
=
36

). Compare the total efficiency of blood transfusion. The levels of Hb, erythrocyte count, hematocrit (HCT), blood oxygen saturation (SPO2), creatinine (Cr), erythrocyte deformability index, whole blood, erythrocyte, and hemoglobin before and after blood transfusion were compared, and the adverse reactions of blood transfusion were recorded. Results. Dyspnea and delirium were significantly associated with patient survival time (

P
<
0.05

). Red blood cell storage

time
≤
14

days,

Lym
%
<
12
%

, lactate dehydrogenase

LDH

>
500

 U/L, and

ALB
<
30

 g/L were significantly correlated with survival time. Karnofsky performance status

KPS

<
30

, delirium,

LDH
>
500

 U/L, and albumin

ALB

<
30

 g/L were independent influencing factors of survival (

P
<
0.05

). The overall effective rate of the research group was higher (

P
<
0.05

). The incidence of adverse reactions in the study group was lower (

P
<
0.05

). The levels of Hb, red blood cell count, and HCT in the study group were higher (

P
<
0.05

). Compared with the control group, the SPO2 level and the red blood cell deformability index were higher in the study group (

P
<
0.05

). After blood transfusion, the level of (diphosphoglycerate) DPG in the study group was higher than that in the control group (

P
<
0.05

). The length of hospital stay in the study group was significantly shortened (

P
<
0.05

). The nosocomial infection rate and case fatality rate in the study group were significantly reduced (

P
<
0.05

). Conclusion. Red blood cell storage

time
≤
14

 d,

LYM
%
<
12
%

,

LDH
>
500

 U/L, and

ALB
<
30

 g/L are all significantly correlated with survival time.

KPS
<
30

, delirium,

LDH
>
500

 U/L, and

ALB
<
30

 g/L were independent factors for survival (

P
<
0.05

). Transfusion of red blood cells stored for ≤14 days in patients with advanced malignant tumors can significantly increase the effective infusion rate, improve anemia status, shorten hospital stay, and reduce mortality and risk of nosocomial infection and is worthy of clinical promotion.
Influence of Compositional Gradient Effect on Tight Condensate Gas Reservoir Development
Authors: Chen Jing , Song Xinmin , Li Baozhu , Luo Xiaoli , Wang Youjing , Wang Jinfang
Published: June 2022

Condensate gas is a transition fluid between oil and gas, which is sensitive to the reservoir temperature and pressure. In condensate gas reservoir, especially in the moderate-giant one, fluid composition often varies with depth. This phenomenon has important influences on development. Anisothermal compositional gradient theory is used to analyze the main factors influencing the compositional gradient distribution to understand the basic regularities of the compositional variation with depth. Geothermal gradient, fluid composition, reservoir temperature, and reservoir pressure will affect the compositional gradient, of which geothermal gradient has the most direct and obvious influence. Furthermore, fluid model with compositional gradient was built in a tight condensate gas reservoir of the Middle East, and the influence of compositional gradient on dynamic performance is evaluated. The results show that the compositional gradient has a significant influence on the original gas in place, development strategy, central processing facilities, and so on. Therefore, compositional gradient requires more attention while exploiting moderate-giant condensate gas reservoirs in order to achieve more economical benefits.
Speckle Noise Removal Model Based on Diffusion Equation and Convolutional Neural Network
Authors: Nao Siwei , Wang Yan
Published: June 2022

The image denoising model based on convolutional neural network (CNN) can achieve a good denoising effect. However, its robustness is poor, and it is not suitable for direct noise removal tasks. Differently, the image denoising method based on the diffusion equation is more stable and has theoretical guarantees. In order to give full play to the advantages of CNN and diffusion equation in image denoising, this paper proposes a speckle noise denoising model via a combination of the two tools. Firstly, based on the mathematical model of speckle noise, a class of neural network speckle noise removal model which mixes residual learning and structure learning is proposed using image decomposition theory. Then, in order to solve the hyperparameter problem that the model depends on noise variance, a noise variance estimation algorithm based on a nonlinear diffusion equation is proposed. Finally, a speckle noise denoising model based on diffusion equation and CNN is obtained. Numerical simulation experiments verify the accuracy of the variance estimation algorithm and also the denoising effect and practical application value of the proposed method.
Development Status and Influencing Factors of Competitive Basketball Management System under the Background of Deep Learning
Authors: Wang Jingfei , Song Xiaoyun
Published: June 2022

Competitive basketball is one of the most popular sports in the world. With the development of China’s sports power strategy, the national movement has strengthened the status of basketball in sports. However, China’s competitive basketball ranking is not high in the world, and the analysis of the reasons should start with the management system. Therefore, this paper aims to explore the development status and influencing factors of China’s competitive basketball management system under the background of deep learning. For the background of deep learning, this paper describes the application of deep learning algorithms in basketball strategy. It adopts the expert interview method for the competitive basketball management system and elaborates in detail on five aspects: target mechanism, competition mechanism, selection mechanism, market mechanism, and incentive mechanism. The experimental results of the article believe that, based on the suggestions of 10 experts, the current Chinese competitive basketball selection mechanism is the most influential factor, with a weight of 16.1%, and the smallest impact is the level of athletes, accounting for 11.4%.
Application of High-Resolution Face Recognition and EDF Image Reconstruction in English Classroom Teaching
Authors: He Shaofang , Zhang Wenjuan
Published: June 2022

This study examines classroom monitoring in order to increase the effectiveness of English classroom instruction. This article uses high-resolution algorithms and EDF image reconstruction technology in the English classroom education system to improve the high resolution of students’ faces. This work presents a fast pixel capture function to enhance the rapid video capture function. The stack velocity picking of the speed spectrum is the most important aspect of velocity analysis. To create successful changes to the algorithm, this method often employs optimization algorithms as a way of stack velocity choosing speed. Finally, based on algorithm improvements, this study builds the system structure and develops simulation tests to validate system performance. The English classroom teaching system created in this work can properly determine the real-time status of students by facial recognition and has excellent user satisfaction, indicating that it may effectively increase the teaching impact, according to experimental research.
The Seepage-Creep Numerical Simulation Model of Coal Measures Sandstone Based on Particle Discrete Element
Authors: Liu Wang , Meng Fanfei , Pu Hai , Wang Jian , Zhang Guohui , Yi Qingyu
Published: June 2022

The stability of the surrounding rock in the goaf is one of the main factors to ensure the safety of the mining production. In this study, a coupled numerical simulation model of particle flow code, computational fluid dynamics, and parallel-bounded stress corrosion (PFC-CFD-PSC model) was proposed to conduct the seepage-creep coupling simulation through PFC 5.0 software. Based on the mechanical results, the crack propagation law of the coal measure sandstone under the mining-induced seepage-creep coupling load was analyzed, and the distribution of pressure gradient in the fluid grid was studied. The results show that seepage pressure has a significant effect on the damage of the rock mass; the greater the seepage pressure on the coal measure sandstone model, the more penetration cracks are generated and the greater the degree of macroscopic damage. When the residual strength is 70% of the peak strength, the damage degree of the coal measure sandstone increases with the increase of the seepage pressure; except for the four corners, the pressure gradient of the fluid at the top of the rock mass model is relatively large. The maximum value of the fluid grid pressure gradient increases with the increasing seepage pressure; it increases slowly under the seepage pressure of less than 1.5 MPa and increases sharply under the seepage pressure of greater than 1.5 MPa.
Identification of the Potential Correlation between Tumor Protein 73 and Head and Neck Squamous Cell Carcinoma
Authors: Chen Yuming
Published: June 2022

Background. Head and neck squamous cell carcinomas (HNSC) are common malignant tumors with a high occurrence and poor prognosis. Tumor protein P73 (TP73) plays an integral role in a wide range of human malignancies, but its gene expression profile, prognostic value, and potential mechanisms in HNSC remain to be comprehensively explored. Objective. This research aimed to elucidate the potential relationship between TP73 and HNSC through bioinformatics analysis. Methods. The Cancer Genome Atlas (TCGA) database was queried to investigate the regulatory role of TP73 in HNSC. The survival probabilities linked to TP73 mRNA were determined via the Kaplan-Meier analysis using R packages. Subsequently, the association of TP73 with several clinical subgroups and immunological subtypes was studied using a cohort from the TCGA-HNSC. Functional analyses were used to identify the potential signaling pathways enriched by the correlated genes of TP73. The relationship between TP73 and immunological aspects, including immune cells, immune inhibitor genes, immune stimulator genes, and tumor immune microenvironment, were investigated. Results. This study showed that the protein and mRNA levels of TP73 in HNSC patients were significantly higher than those in normal tissues. Elevated TP73 expression was related to a better survival outcome in HNSC patients. The TP73 gene was an independent prognostic factor for overall survival in HNSC samples. TP73 was mainly involved in DNA replication, ribosome, apoptosis, mismatch repair, and folate biosynthesis. TP73 was found to be positively correlated with the majority of tumor infiltrating immune cells and immunoinhibitory genes in HNSC. Conclusions. Integrative bioinformatics and statistical analyses displayed that TP73 might serve as a novel marker for the diagnosis and prognosis of HNSC. TP73 modulates immune cells in the tumor microenvironment of HNSC patients, thereby bearing significance for HNSC immunotherapy.
The Influence of Hong Kong-Zhuhai-Macao Bridge on the Development of Urban Agglomeration in the Pearl River Delta
Authors: Zhang Wenjing
Published: June 2022

Known as one of the “seven wonders of the modern world”, the Hong Kong-Zhuhai-Macao Bridge connects Hong Kong, Zhuhai, and Macao. The bridge, which lasted 14 years from design to construction, spans the Lingdingyang waters of the South China Sea to the west, connects Macao and Zhuhai artificial islands, and ends at Zhuhai Hongwan. The bridge, which shortens the traffic distance between the three places and allows the economy, culture, and technology of the three places to communicate with each other, opened up a new world. This paper intends to review the process of the construction of the Hong Kong-Zhuhai-Macao Bridge and sort out the expected benefits of the bridge’s opening to traffic. Then, the paper explains the new situation faced by the Hong Kong-Zhuhai-Macao Bridge. Based on the outward service function model of city flow and the interaction strength model, we conduct an empirical study on the economic status of the Guangdong-Hong Kong-Macao Greater Bay Area. This paper analyzes the interaction between the cities which are in the Greater Bay Area and uses panel data to conduct regression analysis to verify the important impact of the Hong Kong-Zhuhai-Macao Bridge on the development of cities in the Pearl River Delta. Finally, conclusions are drawn: Hong Kong-Zhuhai-Macao Bridge is undoubtedly of positive significance to strengthen economic and social ties between the West Bank of the Pearl River and Hong Kong, and Hong Kong has a large economic radiation capacity to the cities that are in the Pearl River Delta and Macao in the construction, finance, transportation, warehousing, and communications industries. And corresponding suggestions are put forward.
Application of Wireless Network Based on Artificial Intelligence in Network Teaching of Preschool Education Manual and Aesthetic Education Practical Course
Authors: Li Xingping , Xiao Wei
Published: June 2022

For preschool education majors, art and crafts are required courses. This course is a hands-on exercise that helps students develop their creative awareness, design thinking, and hands-on skills. At the same time, it provides learners with the teaching thinking mode of art and handicraft theme and the form of online teaching helps learners to construct the thinking mode of online learning. As a new teaching form, online teaching is gradually leading the reform in the field of education. However, the majority of present online teaching is simply a continuation of traditional teaching thought, relying on substantial teaching research rather than utilizing its particular advantages to develop and expand. Also, the connotation depth of traditional teaching may not involve the essential problem of teaching application itself—teaching methods and experience of acquiring knowledge. As a result, determining how to characterize an individual’s ability to acquire knowledge and successfully assessing the level of growth of an individual’s cognitive structure is critical to the development of a new generation of online education. In order to prepare for the next generation of network teaching, this article uses artificial intelligence and wireless networks to teach preschool education manual and aesthetic education practical courses through the Internet. From the perspectives of individuals and groups, two teaching case recommendation experiments are given. The experiment’s end result confirms the practicality and logic of the evaluation model described in this research, which is based on individual cognitive structure.
Excimer Laser Corneal Refractive Surgery in the Clinic: A Systematic Review and Meta-analysis
Authors: Zhang Huang , Li Mingming , Cen Zhimin
Published: June 2022

Objective. To systematically evaluate the efficacy, safety, recovery speed, and long-term visual quality of excimer laser corneal refractive surgery and to provide evidence-based medicine for the promotion and use of excimer laser corneal refractive surgery. Methods. Randomized controls on excimer laser refractive surgery in Web of science, PubMed, EMBASE, ScienceDirect, Cochrane Library, China Knowledge Network (CNKI), China VIP Database, Wan Fang Database, and China Biomedical Literature Database (CBM) were searched by the computer. Randomized controlled trial (RCT) data were extracted independently by two researchers, and the risk of bias of each included RCT was assessed according to the Cochrane Handbook 5.1.0 criteria. Meta-analysis of the collected data was performed using RevMan5.4 statistical software. Results. In the end, 9 high-quality literatures were included, with a total of 4366 samples, and meta-analysis was used. There was no significant difference in uncorrected visual acuity WMD after excimer laser keratorefractive surgery, but there was a statistically significant difference in WMD in the safety of excimer laser keratorefractive surgery. The results of uncorrected visual acuity (close) indicated the following: Chi2 = 13.56, DF = 5, P = 0.02, and I2 = 100%; the results of uncorrected visual acuity (distance) indicated the following: Chi2 = 34.44, DF =5 (P < 00000), and I2 = 85%; the results of best corrected visual acuity (myopia) indicated the following: Chi2 = 0.65, DF = 3, P = 088 > 0.05, and I2 = 0%; the results of best corrected visual acuity (hyperopia) indicated the following: Chi2 = 1.80, DF = 3, P = 0.61 > 0.05, and I2 = 0%. Conclusion. Excimer laser corneal refractive surgery is safe and effective, with faster recovery and better long-term visual acuity treatment effect. However, more studies and follow-up with higher methodological quality and longer intervention time are needed for further validation.
A Novel Approach Combined with MIPO Technique for the Treatment of Type C Pilon Fractures
Authors: Chen Youhao , Wang Haoming , Li Nan , Xu Lixin , Liu Feng , Xu Qiu , Zhou Qiang , Chen Xiaohua
Published: June 2022

Objective. Type C fracture is a complete intra-articular fracture, and the mainstay of treatment remains open reduction and internal fixation. The purpose of the study is to observe the clinical effect of an anterior ankle C approach (ankle-C) combined with minimal invasive plate osteosystems (MIPO) for tibial pilon fractures (AO/OTA 43C, combined with fibula fractures). Methods. A retrospective comparative analysis was performed on the clinical data of 33 patients with C-type pilon fractures (combined fibula fractures) admitted to our department from July 2018 to July 2021, including 12 cases treated with ankle-C (a-C) approach and 21 cases with conventional approach (including combined approach). All patients were followed up for over 6 months. Visual Analogue Scale (VAS), AOFAS Ankle-Hindfoot Scale (AOFAS-AHS), wound healing time, fracture healing time, and complications were used to evaluate the clinical efficacy. Results. The scores of VAS and AOFAS in the a-C group scored better than the conventional group (

P
<
0.05

), especially in the extent of limited range of motion (LROM) of ankle dorsiflexion-plantarflexion in 1 month after operation and at the last follow-up (

P
<
0.01

). Bone healing was achieved in both groups 6 months after operation, with no implant exposure or infection. Among them, 4 cases in the conventional approach group had wound healing time exceeding 2 weeks. Conclusions. For type C pilon fractures (combined with fibula fractures), ankle-C approach combined with MIPO technique has certain advantages in ankle function recovery and soft tissue repair, which provides an alternative for the treatment of type C pilon fractures.
Long Intergenic Noncoding RNA 00641 Promotes Growth and Invasion of Colorectal Cancer through Regulating miR-450b-5p/GOLPH3 Axis
Authors: Hong Zhongshi , Pan Jianpeng , Chen Mingliang , Deng Xian , Chen Zhichuan , Wang Chunxiao , Qiu Chengzhi
Published: June 2022

Background. Long noncoding RNAs (lncRNAs) have a vital function in tumor onset and progress. For instance, long intergenic noncoding RNA 00641 (LINC00641) has been linked to cancer modulation. Nonetheless, the precise biological roles of LINC00641 in colorectal cancer (CRC) remain elusive. Methods. The expression levels of LINC00641 as well as the docking sites for LINC00641 and miR-450b-5p were analyzed using public data resources and web-based analytic tools. The putative downstream targets of miR-450b-5p were also predicted. Next, we evaluated the biological functions and the contents of LINC00641 in CRC both in vivo and in vitro. We next explored the influence of LINC00641 on the growth, migration, and infiltration of CRC cells via cell proliferation, migration, and invasion experiments. Besides, qRT-PCR, western blotting, flow cytometry, luciferase enzyme reporter assay, and in vivo tumorigenicity assays were conducted. Results. Our results confirmed that LINC00641 was markedly upmodulated in CRC tissues and CRC cell lines, and the upmodulation was linked to poor survival. Notably, the proliferative and migratory abilities of HCT-116 and SW480 cells were significantly inhibited by the knockdown of LINC00641 both in vitro and in vivo, illustrating that LINC00641 exerted a tumor-promotion role in CRC. Mechanistically, LINC00641 could competitively bind miR-450b-5p, thereby expunging its inhibitory effect on GOLPH3 expression. Moreover, miR-450-5p and GOLPH3 were able to reverse LINC00641-mediated cellular processes. Conclusions. Overall, the findings of this study suggest that LINC00641 promotes the proliferative and migratory abilities of CRC through sponging the miR-450b-5p/GOLPH3 axis.
Upregulation of N-Type Voltage-Gated Calcium Channels Induces Neuropathic Pain in Experimental Autoimmune Neuritis
Authors: Mao Mei , Fan Wen , Zheng Yan , Qi Pan , Xi Min , Yao Yuanrong
Published: June 2022

Objective. Guillain–Barré syndrome (GBS) is a common autoimmune disease of the peripheral nervous system, and there is still no effective treatment for GBS. This investigation intends to figure out the effect and mechanism of N-type voltage-gated calcium (Cav2.2) channels on neuropathic pain in GBS. Methods. An experimental autoimmune neuritis (EAN) model was established in Lewis rats induced by myelin P253-78 peptide and complete Freund’s adjuvant. Luxol fast blue (LFB) staining was used for observing the degree of cell infiltration and demyelination in the sciatic nerve of rats, ELISA for detecting IL-6 and TNF-α expression in the serum, qRT-PCR, and Western blot for measuring the expression of iNOS, MCP-1, and Cav2.2 in the sciatic nerve, respectively. Results. EAN led to significant decreases in the mechanical withdrawal threshold, thermal withdrawal threshold, and mechanical hyperalgesia threshold and an increase in the withdrawal threshold to cold stimulation. The serum IL-6 and TNF-α expression was significantly increased, and the mRNA and protein expression of iNOS, MCP-1, and Cav2.2 in the sciatic nerve were significantly increased in the EAN rats. However, silencing Cav2.2 expression could significantly reverse the above EAN-caused results. Conclusion. Silencing Cav2.2 expression can significantly reduce the clinical score, pathological injury, and mechanical allodynia, reducing the release of inflammatory factors, thus improving neuropathic pain in EAN rats.
Study of Neighborhood Degree-Based Topological Indices via Direct and NM-Polynomial of Starphene Graph
Authors: Afzal Deeba , Hameed Saira , Ashraf Usman , Mehmood Arif , Chaudhry Faryal , Thapa Dhan Kumari
Published: June 2022

Our objective is to compute the neighborhood degree-based topological indices via NM-polynomial for starphene. In the neighborhood degree-based topological indices, we compute the third version of the Zagreb index; neighborhood second Zagreb index; neighborhood forgotten topological index; neighborhood second modified Zagreb index; neighborhood general Randic index; neighborhood harmonic index; neighborhood inverse sum index; first, second, third, fourth, and fifth NDe indices; fourth atom bond connective index; fifth geometric arithmetic index; fifth arithmetic-geometric index; fifth hyper-first and second Zagreb index; general first neighborhood index; and Sanskruti index. These neighborhood topological indices are computed both direct and via the NM-polynomial approach.
Application and Evaluation of Sports Event Management Method Based on Recurrent Neural Network
Authors: Mu Xiao , Yin Jiesen , Zhang Luodan
Published: June 2022

The methods of sports event management are the life cycle management method, which can be divided into four stages: start-up planning, plan preparation, real-time control, and followup evaluation. The administrative measures management law includes administrative orders, instructions, regulations, and systems of administrative organizations at all levels. The system management law has four characteristics: mandatory, authoritative, stable, and preventive. The current management mode of sports events is mainly that the government is deeply involved in the operation of the entire event, and relevant personnel are selected from various government departments to form an organizing committee, and the resources related to the event are controlled and regulated by the government. However, in our country, there is currently no unified sports event management standard. Therefore, this paper proposes the application and evaluation of sports event management method based on recurrent neural network (RNN). The comments of sports events are extracted from the network, classified with an RNN, and finally, an improvement plan is obtained through evaluation. The main work of this paper is as follows: (1) the development status of sports event management at home and abroad and the application of RNN are introduced, and RNN is used in the evaluation and classification of sports event management. (2) We propose a sentiment classification model GCNN-GRU that fuses local feature extraction. Aiming at the defect that the basic model is easy to lose key phrase information, a CNN with a gating mechanism is used to extract and filter local features. The classification experiment results show that the proposed GCNN-GRU has the best classification effect on the Chinese sentiment dataset.
Corpus-Driven Resource Recommendation Algorithm for English Online Autonomous Learning
Authors: Gu Ling
Published: June 2022

One of the most significant aspects of English teaching, as well as the embodiment of students’ comprehensive English skill, is the cultivation of English learning ability. Teachers of English should help students understand the topic’s material and be able to convey, describe, and analyze the topic’s substance, such as summarizing, subjective judgments analysis, and tale continuation. Students’ English learning is restricted by the learning environment, teachers’ quality, students’ own ability, and other aspects. Furthermore, schools and families do not prioritize English learning, resulting in low teacher expectations for English instruction, as well as a lack of English practice and strategy training among students. In order to improve the inefficiency of English teaching, this paper combines corpus technology with English teaching and proposes an online autonomous learning resource recommendation algorithm. The model is optimized in the aspects of high efficiency, diversity, and timeliness of learning resource recommendation supported by deep learning technology. The model is pretrained through the processed dataset, and the algorithm designed in this study is compared with the classical algorithm to verify the rationality and effectiveness of the algorithm designed in this study. Based on the previous studies, this study attempts to apply the teaching model combining corpus and recommendation algorithm to online teaching, so as to optimize English teaching model and teaching methods.
Macular and Optic Disc Parameters in Children with Amblyopic and Nonamblyopic Eyes under Optical Coherence Tomography Fundus Images
Authors: Zhu Dan , Sun Qiang , Yang Hong , Zou Yangcheng , Liu Chunmei , Xu Yan
Published: June 2022

The aim of this study was to investigate the characteristics of macular and optic disc parameters in children with amblyopic and nonamblyopic eyes, using fundus images under optical coherence tomography (OCT). 36 patients with anisometropic amblyopia were selected in the experimental group, and another 36 healthy volunteers were selected in the control group, OCT examinations were performed in all groups, and the mean diopter, mean corrected visual acuity (CVA), mean axial length, mean optic disc retinal nerve fiber layer (RNFL) thickness, and mean macular fovea thickness were recorded in the two groups. The results found that the average diopter of the patients in the control group and the experimental group was

+
2.30
±
2.54

 D and

+
5.51
±
1.76

 D, respectively. The average CVA was

0.86
±
0.07

and

0.22
±
0.16

, respectively; the average eye axial length was

22.41
±
1.20

 mm and

21.11
±
0.78

 mm, respectively. As

P
<
0.05

, the differences were statistically significant in the three indicators between the two groups. There was no significant difference between the two groups in the average thickness of the RNFL of the optic disc and the average thickness of the central fovea of macula (

P
>
0.05

). There was some correlation among CVA, diopter, eye axial length, RNFL thickness, and average thickness of macular fovea, but the correlation was not significant. It was suggested that there were certain differences in the macular and optic disc parameters between amblyopic and nonamblyopic children, but the difference is little. Thereout, a certain objective basis was provided for the early detection and treatment of amblyopia.
Abstract 1020: Cancer health awareness through screening and education (CHANGE): Understanding community experience accessing cancer care
Authors: Vernon Marlo M. , Jones Samantha , Moore Justin X. , Coughlin Steve S. , Heboyan Vahe , Clarke Shakirah , Idun Barbara , Tingen Martha S.
Published: June 2022

INTRODUCTION. Incidence and mortality rates for breast, prostate, and colorectal cancers all exceed national rates in Georgia and are higher among African Americans (AAs). Ensuring culturally competent and equitable health care delivery relies on creating an educated and engaged health care team. Patient stories are powerful examples of community-learned experiences and can be used to educate better providers and health care students who serve diverse populations, particularly when communicating risk and prevention of cancer. The goal of the CHANGE project is to provide a sustainable model of evidence-based cancer awareness through education - with an emphasis on prevention and early detection behaviors. We will develop a health disparities and culturally competent cancer care e-Learning curriculum for health care professionals, hematology-oncology fellows, residents, and medical students at the Medical College of Georgia.

METHODS. Thirty community members and stakeholders (93% AA, 76% female, all adults) were recruited through public housing, healthcare clinics and providers, and community organizations. Vignettes describing patient access and care interactions were used in semi-structured interviews to guide conversations about experiences accessing care, attitudes towards cancer prevention, and community cancer beliefs. Interviews were recorded, professionally transcribed, and content analyzed using NVivo 12.0 by two independent raters.

RESULTS. Three common themes emerged: accessibility of healthcare (transportation, finances, and difficulties in scheduling were primary barriers); cancer myths and cultural norms (no interpersonal discussion of cancer, seen as “taboo,” cancer will spread if cut into and cancer is contagious); and experience of racial bias in health care (historical racial bias and systemic racism; receipt of treatment and care perceived to be different due to race; lack of AA providers).

CONCLUSION. This sample adequately represented those most at risk for cancer in Augusta, GA area. Their shared experiences will be used to design and inform an e-learning curriculum, in conjunction with education on health disparities across the state and specific to the local community. This will provide a comprehensive approach to provider education that will begin to improve patient care satisfaction and health outcomes.

Citation Format: Marlo M. Vernon, Samantha Jones, Justin X. Moore, Steve S. Coughlin, Vahe Heboyan, Shakirah Clarke, Barbara Idun, Martha S. Tingen. Cancer health awareness through screening and education (CHANGE): Understanding community experience accessing cancer care [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1020.
Abstract 1095: Establishment and characterization of a topotecan resistant lung cancer NCI H460/TPT10 cell line and a tumor xenograft model
Authors: Teng Qiu-Xu , Lei Zi-Ning , Zhang Wei , Fan Ying-Fang , Wang Jing-Quan , Cai Chao-Yun , Yang Dong-Hua , Wurpel John , Chen Zhe-Sheng
Published: June 2022

While topotecan (TPT) is a chemotherapeutic drug in treating lung cancer, the development of TPT resistance in tumors reserves as a major obstacle to chemotherapeutic success. Therefore, a better understanding of the mechanisms of TPT resistance is critical. In this study, the first topotecan-resistant human non-small cell lung cancer (NSCLC) cell line, termed NCI-H460/TPT10, was established from the parental NCI-H460 cell line. NCI-H460/TPT10 cells exhibited a 394.7-fold resistance to TPT, and cross-resistance to SN-38, mitoxantrone, and doxorubicin, compared to parental NCI-H460 cells. Overexpression of ABCG2 localized on the cell membrane, but not ABCB1 or ABCC1, was found in NCI-H460/TPT10 cells, indicating that ABCG2 was likely to be involved in TPT-resistance. This was confirmed by the abolishment of drug resistance in NCI-H460/TPT10 cells after ABCG2 knockout. Moreover, the involvement of functional ABCG2 as a drug efflux pump conferring multidrug resistance (MDR) was indicated by low intracellular accumulation of TPT in NCI-H460/TPT10 cells, and the reversal effects by ABCG2 inhibitor Ko143 and cabozantinib. The NCI-H460/TPT10 and its parental cell line were further used to establish in vivo tumor xenograft mouse models, which verified their capability to serve as clinically relevant models for drug screening and the development of targeted strategies to overcome ABCG2-mediated MDR in NSCLC.

Citation Format: Qiu-Xu Teng, Zi-Ning Lei, Wei Zhang, Ying-Fang Fan, Jing-Quan Wang, Chao-Yun Cai, Dong-Hua Yang, John Wurpel, Zhe-Sheng Chen. Establishment and characterization of a topotecan resistant lung cancer NCI H460/TPT10 cell line and a tumor xenograft model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1095.