bluuebunny/crossref_metadata_2025 huggingface dataset:
An explorative metabolomic analysis of the endothelium in pulmonary hypertension
Authors: Carlsen J. , Henriksen H. H. , Marin de Mas I. , Johansson P. I.
Published: August 2022

Pulmonary hypertension (PH) is classified into five clinical diagnostic groups, including group 1 [idiopathic pulmonary arterial hypertension (IPAH) and connective tissue disease-associated PAH (CTD-aPAH)] and group 4 (chronic thromboembolic pulmonary hypertension (CTEPH)). PH is a progressive, life-threatening, incurable disease. The pathological mechanisms underlying PH remain elusive; recent evidence has revealed that abnormal metabolic activities in the endothelium may play a crucial role. This research introduces a novel approach for studying PH endothelial function, building on the genome-scale metabolic reconstruction of the endothelial cell (EC) to investigate intracellular metabolism. We demonstrate that the intracellular metabolic activities of ECs in PH patients cluster into four phenotypes independent of the PH diagnosis. Notably, the disease severity differs significantly between the metabolic phenotypes, suggesting their clinical relevance. The significant metabolic differences between the PH phenotypes indicate that they may require different therapeutic interventions. In addition, diagnostic capabilities enabling their identification is warranted to investigate whether this opens a novel avenue of precision medicine.
Modeling eye movement in dynamic interactive tasks for maximizing situation awareness based on Markov decision process
Authors: Ma Shuo , Guo Jianbin , Zeng Shengkui , Che Haiyang , Pan Xing
Published: August 2022

For complex dynamic interactive tasks (such as aviating), operators need to continuously extract information from areas of interest (AOIs) through eye movement to maintain high level of situation awareness (SA), as failures of SA may cause task performance degradation, even system accident. Most of the current eye movement models focus on either static tasks (such as image viewing) or simple dynamic tasks (such as video watching), without considering SA. In this study, an eye movement model with the goal of maximizing SA is proposed based on Markov decision process (MDP), which is designed to describe the dynamic eye movement of experienced operators in dynamic interactive tasks. Two top-down factors, expectancy and value, are introduced into this model to represent the update probability and the importance of information in AOIs, respectively. In particular, the model regards sequence of eye fixations to different AOIs as sequential decisions to maximize the SA-related reward (value) in the context of uncertain information update (expectancy). Further, this model was validated with a flight simulation experiment. Results show that the predicted probabilities of fixation on and shift between AOIs are highly correlated ($$R = 0.928$$

R
=
0.928

and $$R = 0.951$$

R
=
0.951

, respectively) with those of the experiment data.
Coordination dynamics of thoracic and abdominal movements during voluntary breathing
Authors: Higashino Mimu , Miyata Kohei , Kudo Kazutoshi
Published: August 2022

Thoracic and abdominal movements can be tightly coupled during voluntary breathing, such as when singing and playing wind instruments. The present study investigated the coordination of thoracic and abdominal movements during voluntary breathing using a dynamical systems approach. We examined whether there are two stable coordination patterns, and if the coordination pattern would abruptly change when the breathing frequency increased, which is known as phase transition. The participants inhaled and exhaled repeatedly at 7.5, 15, 30, 60, or 120 breaths per minute. At the beginning and end of the experiment, the participants performed breathing at their preferred frequency. As a result, the coordination pattern at the lower and preferred frequencies exhibited an in-phase pattern. When breathing frequency increased, participants showed deviated coordination patterns from the in-phase pattern to either a thoracic-leading pattern, an abdominal-leading pattern, or an anti-phase pattern depending on the individual. These deviations occurred gradually; thus, phase transition was not observed. Our findings suggest that thoracic and abdominal movements are tightly coupled at lower frequencies, but their patterns vary depending on the breathing frequency and individuals. Therefore, the present study suggests the importance of viewing breath control in terms of coordination of thoracic and abdominal movements.
Bioinformatics analysis reveals potential biomarkers associated with the occurrence of intracranial aneurysms
Authors: Zhao Chao , Ma Zhiguo , Shang Junliang , Cui Xinchun , Liu Jinxing , Shi Ronghua , Wang Shuai , Wu Aihong
Published: August 2022

To better understand the molecular mechanisms of intracranial aneurysm (IA) pathogenesis, we used gene coexpression networks to identify hub genes and functional pathways associated with IA onset. Two Gene Expression Omnibus (GEO) datasets encompassing intracranial aneurysm tissue samples and cerebral artery control samples were included. To discover functional pathways and potential biomarkers, weighted gene coexpression network analysis was employed. Next, single-gene gene set enrichment analysis was employed to investigate the putative biological roles of the chosen genes. We also used receiver operating characteristic analysis to confirm the diagnostic results. Finally, we used a rat model to confirm the hub genes in the module of interest. The module of interest, which was designated the green module and included 115 hub genes, was the key module that was most strongly and negatively associated with IA formation. According to gene set variation analysis results, 15 immune-related pathways were significantly activated in the IA group, whereas 7 metabolic pathways were suppressed. In two GEO datasets, SLC2A12 could distinguish IAs from control samples. Twenty-nine hub genes in the green module might be biomarkers for the occurrence of cerebral aneurysms. SLC2A12 expression was significantly downregulated in both human and rat IA tissue. In the present study, we identified 115 hub genes related to the pathogenesis of IA onset and deduced their potential roles in various molecular pathways; this new information may contribute to the diagnosis and treatment of IAs. By external validation, the SLC2A12 gene may play an important role. The molecular function of SLC2A12 in the process of IA occurrence can be further studied in a rat model.
A heat-flux upper boundary for modeling temperature of soils under an embankment in permafrost region
Authors: Wang Tianyu , Yan Li-E.
Published: August 2022

Building roads in permafrost region is challenged because permafrost is sensitive to temperature increase. As an embankment gains/drains heat mostly at the upper surface, accurately modeling the heat transfer in the upper surface is crucial to understand the thermal stability of the road. Popular methods treat the upper boundary as a temperature-controlled model (TCM), where temperature of the upper surface is set as a sinusoidal function. This simple function, however, fails to identify the influences of solar irradiance, heat convection, and thermal irradiance on the heat transfer on the ground surface. Here we introduce a heat-flux model (HFM) to calculate the heat fluxes at the embankment upper surface and at the adjacent ground surface. HFM-predicted temperature under an embankment is compared against the observed temperature to validate the model, and is compared to the TCM-predicted temperature. While TCM-predicted temperatures and HFM-predicted ones are similar in trend and in pattern, the HFM-predicted temperatures are far more coincident with the observed ones. The pros and cons of both HFM and TCM are discussed. Further studies are expected to use HFM to understand the heat flux components such as solar absorption, heat convection, and thermal irradiance on the temperature of permafrost under embankments.
Empirical facts from search for replicable associations between cortical thickness and psychometric variables in healthy adults
Authors: Kharabian Masouleh Shahrzad , Eickhoff Simon B. , Maleki Balajoo Somayeh , Nicolaisen-Sobesky Eliana , Thirion Bertrand , Genon Sarah
Published: August 2022

The study of associations between inter-individual differences in brain structure and behaviour has a long history in psychology and neuroscience. Many associations between psychometric data, particularly intelligence and personality measures and local variations of brain structure have been reported. While the impact of such reported associations often goes beyond scientific communities, resonating in the public mind, their replicability is rarely evidenced. Previously, we have shown that associations between psychometric measures and estimates of grey matter volume (GMV) result in rarely replicated findings across large samples of healthy adults. However, the question remains if these observations are at least partly linked to the multidetermined nature of the variations in GMV, particularly within samples with wide age-range. Therefore, here we extended those evaluations and empirically investigated the replicability of associations of a broad range of psychometric variables and cortical thickness in a large cohort of healthy young adults. In line with our observations with GMV, our current analyses revealed low likelihood of significant associations and their rare replication across independent samples. We here discuss the implications of these findings within the context of accumulating evidence of the general poor replicability of structural-brain-behaviour associations, and more broadly of the replication crisis.
Fossoriality in desert-adapted tenebrionid (Coleoptera) larvae
Authors: Raś Marcin , Kamiński Marcin Jan , Iwan Dariusz
Published: August 2022

In many extreme arid ecosystems, insects constitute major faunal components and are key contributors in nutrient cycling. Previous research on xerophily in insects has focused on adult forms. This study investigates skeletomuscular and behavioural adaptations of the Kalahari sandworm beetle larvae (Gonopus tibialis Fabricius) for dwelling in the sand. Microcomputed tomography enabled cuticle thickness distribution analysis, revealing structural reinforcements of the mandibular edge, the middle part of the head, and the ventral side of the front legs. Laboratory observations and the analysis of muscular system allowed for the definition and functional description of the elements of the digging apparatus of the sandworm larvae. Obtained results point to the crucial role of the head and mandibles in the digging process. These observations are important for understanding desert ecology and pose a challenge to develop newer excavation techniques.
Serum myo-inositol oxygenase levels at hospital discharge predict progression to chronic kidney disease in community-acquired acute kidney injury
Authors: Kakkanattu Tom Jose , Kaur Jaskiran , Nagesh Vinod , Kundu Monica , Kamboj Kajal , Kaur Prabhjot , Sethi Jasmine , Kohli Harbir Singh , Gupta Kishan Lal , Ghosh Arpita , Kumar Vivek , Yadav Ashok Kumar , Jha Vivekanand
Published: August 2022

Acute kidney injury (AKI) increases the risk of morbidity, mortality, and progression to chronic kidney disease (CKD). There are few data on the risk of CKD following community-acquired AKI (CA-AKI) and its predictors from developing countries. We evaluated the association of a panel of serum and urine biomarkers at the time of hospital discharge with 4-month renal outcome in CA-AKI. Patients of either sex, aged between 18 and 70 years, with no underlying CKD, and with CA-AKI were recruited at the time of discharge from hospital in this prospective observational study. Levels of serum and urine biomarkers were analyzed and association between these markers and development of CKD, defined as eGFR < 60 ml/min/1.73 m2or dialysis dependence at 4 month after discharge, were analyzed using multivariate logistic regression analysis and penalized least absolute shrinkage and selection operator logistic regression. Out of a total 126 patients followed up for 4 months, 25 developed CKD. Those who developed CKD were older (p = 0.008), had higher serum creatinine (p < 0.001) and lower serum albumin (p = 0.001) at discharge. Adjusted logistic regression showed that each 10% increase in standardized serum myo-inositol oxygenase (MIOX) level increased the odds of progression to CKD by 13.5%. With 10% increase in standardized urine Neutrophil gelatinase-associated lipocalin (NGAL), serum creatinine and urine protein creatinine ratio (uPCR), increase in the odds of progression to CKD was 10.5%, 9.6% and 8%, respectively. Multivariable logistic model including serum MIOX, discharge serum creatinine and discharge uPCR, was able to predict the progression of CKD [AUC ROC 0.88; (95% CI 0.81, 0.95)]. High level serum MIOX levels at the time of discharge from hospital are associated with progression to CKD in patients with CA-AKI.
Immersive ultraviolet disinfection of E. coli and MS2 phage on woven cotton textiles
Authors: MacIsaac Sean A. , Mullin Toni J. , Munoz Sebastian , Ontiveros C. Carolina , Gagnon Graham A.
Published: August 2022

Immersive ultraviolet disinfection provides a chemical-free technology for safer textiles, surfaces, and public spaces by inactivating communicable pathogens. This study examined immersive UV disinfection, using a disinfection cabinet, of E. coli and MS2 that was inoculated on white cotton T-shirts. The impact that porous materials have on UV disinfection is poorly understood with the majority of previous surface disinfection research focusing on hard, smooth surfaces. Several approaches were used in this study to characterize the light dynamics within the disinfection cabinet including colorimetric dosimetry coupons, biodosimetry, and spectroradiometry. Micro and macro geometry of porous surfaces are important factors to consider when using immersive UV technologies. The geometry of the cabinet impacted the distribution of emitted UV light within the disinfection cabinet and the physical properties of a porous material, such as the woven pattern of cotton, both contribute to UV disinfection efficiency. This work identified that light distribution is crucial for immersive UV technologies as the delivered fluence was highly variable within the disinfection cabinet and resulted in a difference of several logs of reduction for adjacent areas of T-shirt samples. Other inoculated areas achieved upwards of 1-log reductions values for MS2 and upwards of 2-log reductions for E. coli.
Identifying subtypes of HIV/AIDS-related symptoms in China using latent profile analysis and symptom networks
Authors: Yang Zhongfang , Zhu Zheng , Wen Huan , Han Shuyu , Zhang Lin , Fu Yanfen , Hu Yan , Wu Bei
Published: August 2022

The identification of subgroups of people living with HIV in China based on the severity of symptom clusters and individual symptoms is crucial to determine group-specific symptom management strategies. Participants reported 27 highly prevalent HIV/AIDS-related symptoms. Latent profile analysis based on symptom severity was used to identify person-centered subtypes of HIV/AIDS-related symptoms. Symptom networks were compared among subgroups identified by latent profile analysis. A total of 2927 eligible people living with HIV (PWH) were included in the analysis. Five profiles were identified: “Profile 1: all low symptom severity” (n2 = 2094, 71.54%), “Profile 2: medium symptom severity with syndemic conditions” (n3 = 109, 3.72%), “Profile 3: medium symptom severity with low functional status” (n1 = 165, 5.64%), “Profile 4: medium symptom severity in transitional period” (n4 = 448, 15.31%), and “Profile 5: all high symptom severity” (n5 = 111, 3.79%). Except for Profile 1 and Profile 5, the symptom severity was similar among the other three profiles. Profiles 1 (2.09 ± 0.52) and 4 (2.44 ± 0.66) had the smallest ∑s values, and Profiles 2 (4.38 ± 1.40) and 5 (4.39 ± 1.22) had the largest ∑s values. Our study demonstrates the need for health care professionals to provide PWH with group-specific symptom management interventions based on five profiles to improve their physical and psychological well-being. Future studies should be conducted in different contexts using different symptom checklists to further validate our results.
Stronger decadal variability of the Kuroshio Extension under simulated future climate change
Authors: Joh Youngji , Delworth Thomas L. , Wittenberg Andrew T. , Cooke William F. , Rosati Anthony J. , Zhang Liping
Published: August 2022

Understanding the behavior of western boundary current systems is crucial for predictions of biogeochemical cycles, fisheries, and basin-scale climate modes over the midlatitude oceans. Studies indicate that anthropogenic climate change induces structural changes in the Kuroshio Extension (KE) system, including a northward migration of its oceanic jet. However, changes in the KE temporal variability remain unclear. Using large ensembles of a global coupled climate model, we show that in response to increasing greenhouse gases, the time scale of KE sea surface height (SSH) shifts from interannual scales toward decadal and longer scales. We attribute this increased low-frequency KE variability to enhanced mid-latitude oceanic Rossby wave activity induced by regional and remote atmospheric forcing, due to a poleward shift of midlatitude surface westerly with climatology and an increase in the tropical precipitation activity, which lead to stronger atmospheric teleconnections from El Niño to the midlatitude Pacific and the KE region. Greenhouse warming leads to both a positive (elongated) KE state that restricts ocean perturbations (e.g., eddy activity) and stronger wind-driven KE fluctuations, which enhances the contributions of decadal KE modulations relative to short-time scale intrinsic oceanic KE variations. Our spectral analyses suggest that anthropogenic forcing may alter the future predictability of the KE system.
Targeted inhibition of ubiquitin signaling reverses metabolic reprogramming and suppresses glioblastoma growth
Authors: Delle Donne Rossella , Iannucci Rosa , Rinaldi Laura , Roberto Luca , Oliva Maria A. , Senatore Emanuela , Borzacchiello Domenica , Lignitto Luca , Giurato Giorgio , Rizzo Francesca , Sellitto Assunta , Chiuso Francesco , Castaldo Salvatore , Scala Giovanni , Campani Virginia , Nele Valeria , De Rosa Giuseppe , D’Ambrosio Chiara , Garbi Corrado , Scaloni Andrea , Weisz Alessandro , Ambrosino Concetta , Arcella Antonella , Feliciello Antonio
Published: August 2022

Glioblastoma multiforme (GBM) is the most frequent and aggressive form of primary brain tumor in the adult population; its high recurrence rate and resistance to current therapeutics urgently demand a better therapy. Regulation of protein stability by the ubiquitin proteasome system (UPS) represents an important control mechanism of cell growth. UPS deregulation is mechanistically linked to the development and progression of a variety of human cancers, including GBM. Thus, the UPS represents a potentially valuable target for GBM treatment. Using an integrated approach that includes proteomics, transcriptomics and metabolic profiling, we identify praja2, a RING E3 ubiquitin ligase, as the key component of a signaling network that regulates GBM cell growth and metabolism. Praja2 is preferentially expressed in primary GBM lesions expressing the wild-type isocitrate dehydrogenase 1 gene (IDH1). Mechanistically, we found that praja2 ubiquitylates and degrades the kinase suppressor of Ras 2 (KSR2). As a consequence, praja2 restrains the activity of downstream AMP-dependent protein kinase in GBM cells and attenuates the oxidative metabolism. Delivery in the brain of siRNA targeting praja2 by transferrin-targeted self-assembling nanoparticles (SANPs) prevented KSR2 degradation and inhibited GBM growth, reducing the size of the tumor and prolonging the survival rate of treated mice. These data identify praja2 as an essential regulator of cancer cell metabolism, and as a potential therapeutic target to suppress GBM growth.
Reduced calcium levels and accumulation of abnormal insulin granules in stem cell models of HNF1A deficiency
Authors: González Bryan J. , Zhao Haoquan , Niu Jacqueline , Williams Damian J. , Lee Jaeyop , Goulbourne Chris N. , Xing Yuan , Wang Yong , Oberholzer Jose , Blumenkrantz Maria H. , Chen Xiaojuan , LeDuc Charles A. , Chung Wendy K. , Colecraft Henry M. , Gromada Jesper , Shen Yufeng , Goland Robin S. , Leibel Rudolph L. , Egli Dieter
Published: August 2022

Mutations in HNF1A cause Maturity Onset Diabetes of the Young (HNF1A-MODY). To understand mechanisms of β-cell dysfunction, we generated stem cell-derived pancreatic endocrine cells with hypomorphic mutations in HNF1A. HNF1A-deficient β-cells display impaired basal and glucose stimulated-insulin secretion, reduced intracellular calcium levels in association with a reduction in CACNA1A expression, and accumulation of abnormal insulin granules in association with SYT13 down-regulation. Knockout of CACNA1A and SYT13 reproduce the relevant phenotypes. In HNF1A deficient β-cells, glibenclamide, a sulfonylurea drug used in the treatment of HNF1A-MODY patients, increases intracellular calcium, and restores insulin secretion. While insulin secretion defects are constitutive in β-cells null for HNF1A, β-cells heterozygous for hypomorphic HNF1A (R200Q) mutations lose the ability to secrete insulin gradually; this phenotype is prevented by correction of the mutation. Our studies illuminate the molecular basis for the efficacy of treatment of HNF1A-MODY with sulfonylureas, and suggest promise for the use of cell therapies.
Bone marrow imaging reveals the migration dynamics of neonatal hematopoietic stem cells
Authors: Takihara Yuji , Higaki Takumi , Yokomizo Tomomasa , Umemoto Terumasa , Ariyoshi Kazunori , Hashimoto Michihiro , Sezaki Maiko , Takizawa Hitoshi , Inoue Toshihiro , Suda Toshio , Mizuno Hidenobu
Published: August 2022

Hematopoietic stem cells (HSCs) are produced from the blood vessel walls and circulate in the blood during the perinatal period. However, the migration dynamics of how HSCs enter the bone marrow remain elusive. To observe the dynamics of HSCs over time, the present study develops an intravital imaging method to visualize bone marrow in neonatal long bones formed by endochondral ossification which is essential for HSCnicheformation. Endogenous HSCs are labeled with tdTomato under the control of an HSC marker geneHlf, and a customized imaging system with a bone penetrating laser is developed for intravital imaging of tdTomato-labeled neonatal HSCs in undrilled tibia, which is essential to avoid bleeding from fragile neonatal tibia by bone drilling. The migration speed of neonatal HSCs is higher than that of adult HSCs. Neonatal HSCs migrate from outside to inside the tibia via the blood vessels that penetrate the bone, which is a transient structure during the neonatal period, and settle on the blood vessel wall in the bone marrow. The results obtained from direct observations in vivo reveal the motile dynamics and colonization process of neonatal HSCs during bone marrow formation.
Pathway elucidation of bioactive rhamnosylated ginsenosides in Panax ginseng and their de novo high-level production by engineered Saccharomyces cerevisiae
Authors: Li Chaojing , Yan Xing , Xu Zhenzhen , Wang Yan , Shen Xiao , Zhang Lei , Zhou Zhihua , Wang Pingping
Published: August 2022

Rg2 and Re are both rhamnose-containing ginsenosides isolated exclusively from Panax plants, which exhibit broad spectrum of pharmacological activities. However, limitations of current plant-relied manufacturing methods have largely hampered their medical applications. Here, we report elucidation of the complete biosynthetic pathway of these two ginsenosides by the identification of a rhamnosyltransferase PgURT94 from Panax ginseng. We then achieve de novo bio-production of Rg2 and Re from glucose by reconstituting their biosynthetic pathways in yeast. Through stepwise strain engineering and fed-batch fermentation, the maximum yield of Rg2 and Re reach 1.3 and 3.6 g/L, respectively. Our work completes the identification of the last missing enzyme for Rg2 and Re biosynthesis and achieves their high-level production by engineered yeasts. Once scaled, this microbial biosynthesis platform will enable a robust and stable supply of Rg2 and Re and facilitate their food and medical applications.
Human mobility and infection from Covid-19 in the Osaka metropolitan area
Authors: Kato Haruka , Takizawa Atsushi
Published: August 2022

Controlling human mobility is thought to be an effective measure to prevent the spread of the COVID-19 pandemic. This study aims to clarify the human mobility types that impacted the number of COVID-19 cases during the medium-term COVID-19 pandemic in the Osaka metropolitan area. The method used in this study was analysis of the statistical relationship between human mobility changes and the total number of COVID-19 cases after two weeks. In conclusion, the results indicate that it is essential to control the human mobility of groceries/pharmacies to between −5 and 5% and that of parks to more than −20%. The most significant finding for urban sustainability is that urban transit was not found to be a source of infection. Hence governments in cities around the world may be able to encourage communities to return to transit mobility, if they are able to follow the kind of hygiene processes conducted in Osaka.
Carbon accumulation rates are highest at young and expanding salt marsh edges
Authors: Miller Carson B. , Rodriguez Antonio B. , Bost Molly C. , McKee Brent A. , McTigue Nathan D.
Published: August 2022

An objective of salt marsh conservation, restoration, and creation is to reduce global carbon dioxide levels and offset emissions. This strategy hinges on measurements of salt marsh carbon accumulation rates, which vary widely creating uncertainty in monetizing carbon credits. Here, we show the 14–323 g C m−2 yr−1 range of carbon accumulation rates, derived from cores collected at seven sites in North Carolina U.S.A., results from the landward or basinward trajectory of salt marsh colonization and the intertidal space available for accretion. Rates increase with accelerating sea-level rise and are highest at young and expanding marsh edges. The highest carbon densities are near the upland, highlighting the importance of this area for building a rich stock of carbon that would be prevented by upland development. Explaining variability in carbon accumulation rates clarifies appraisal of salt marsh restoration projects and landscape conversion, in terms of mitigating green-house gas emissions.
Influence and prediction value of Arctic sea ice for spring Eurasian extreme heat events
Authors: Sun Jianqi , Liu Sichang , Cohen Judah , Yu Shui
Published: August 2022

In spring, Eurasia has experienced significant warming, accompanied by frequent extreme heat events. Whether the Arctic sea ice has contributed to the variation of spring Eurasian extreme heat events is still unclear. Here, through conducting statistical analyses of observed and reanalysis data, we demonstrate that the winter sea ice anomalies over the Barents-Kara Seas dominate the leading mode of interannual variation of spring extreme heat events over mid-to-high latitude Eurasia in the recent two decades. With faster decline rate and larger variability, the winter sea ice anomalies over the Barents-Kara Seas significantly enhance the troposphere-stratosphere interactions and further exert influence on the spring atmospheric circulations that favor the formation of Eurasian extreme heat events. Cross-validated hindcasts of the dipole mode index of spring extreme heat events using winter sea ice anomalies over the Barents-Kara Seas yield a correlation skill of 0.71 over 2001–2018, suggesting that nearly 50% of its variance could be predicted one season in advance.
Fabrication of Ce-doped DUT-52 as a sorbent for dispersive solid phase extraction of estrogens in human urine samples
Authors: Guo Linan , Wang Yahui , Yan Meng , Li Xinxin , Jiang Xinyao , Wang Manman , Wang Qian , Wang Xuesheng , Hao Yulan
Published: August 2022

A cerium (Ce)-doped metal–organic framework composite (Ce/DUT-52) was prepared by using a solvothermal method and was explored as a sorbent for dispersive solid phase extraction (DSPE) of three estrogens in human urine samples.
Selective olefin production on silica based iron catalysts in Fischer–Tropsch synthesis
Authors: Lee Sungwoo , Seo Jeong-Cheol , Chun Hee-Joon , Yang Sunkyu , Sim Eun-hae , Lee Jechan , Kim Yong Tae
Published: August 2022

Mixed phases of Fe3O4 and Fe5C2, interacting properly with SiO2, produce highly selective olefins from syngas.
Size-dependent Al-doped SrTiO3affecting solar-driven overall water splitting
Authors: Su Zhiyuan , Fang Fan , Liu Shuaishuai , Wang Ni , Wan Yutong , Guo Donglei , Han Wenjun , Chang Kun
Published: August 2022

The equilibrium relationship between the charge transfer and gas evolution capacities of reasonable size Al-STO nanoparticles induces the balance point of HER and OER half-reactions.
Sensitivity of ice nucleation parameterizations to the variability in underlying ice nucleation rate coefficients
Authors: Steinke Isabelle , Burrows Susannah M.
Published: August 2022

We use simulated droplet freezing experiments to probe the impact of variability in ice nucleation propensities (represented as differently-shaped distributions), and observe differences at low frozen fractions and for broad distributions.
Construction of facilitated mass transfer composite membranes with triple-layer water nanochannel architecture for forward osmosis process using cGO-coated polysulfone separation membrane as the substrate
Authors: Li Hongbin , Shi Wenying , Su Yuheng , Fan Mengjie , Li Tengfei , Ma Sisi , Tian Yin , Wang Zongsheng
Published: August 2022

Forward osmosis (FO) composite membrane with triple-layer water nanochannel architecture was constructed using carboxylated graphene oxide (cGO)-polyamide (PA) composite through interfacial polymerization (IP) to improve membrane permeability.
The effects of grape seed proanthocyanidins in cafeteria diet-induced obese Fischer 344 rats are influenced by faecal microbiota in a photoperiod dependent manner
Authors: Arreaza-Gil Verónica , Escobar-Martínez Iván , Muguerza Begoña , Aragonès Gerard , Suárez Manuel , Torres-Fuentes Cristina , Arola-Arnal Anna
Published: August 2022

GSPE anti-obesity effects are modulated by the gut microbiota in a photoperiod-dependent manner.
Two new catechins from Zijuan green tea enhance the fitness and lifespan of Caenorhabditis elegans via insulin-like signaling pathways
Authors: Ke Jia-Ping , Yu Jing-Ya , Gao Biao , Hu Feng-Lin , Xu Feng-Qing , Yao Guangmin , Bao Guan-Hu
Published: August 2022

Two new catechins, zijuanin E (1) and zijuanin F (2), were isolated from Zijuan green tea. 1 and 2 (100 μM) prolonged the lifespan of C. elegans by 67.2% and 56.0%, respectively, delaying the age-related decline of phenotypes, enhancing stress resistances, and reducing ROS and lipid accumulation.
Transamidated wheat gliadin induces differential antigen recognition in the small intestine of HLA/DQ8 transgenic mice
Authors: Treppiccione Lucia , Maurano Francesco , Rossi Stefano , Luongo Diomira , Rossi Mauro
Published: August 2022

In DQ8 mice IFN-γ secretion was significantly reduced when mesenteric gliadin-specific cells were stimulated with transamidated gliadin. Pro-inflammatory markers of innate immunity are stimulated by native gliadin but not by transamidated gliadin.
Correction: Recent advances in microfluidic-based electroporation techniques for cell membranes
Authors: Wang Fei , Lin Shujing , Yu Zixian , Wang Yanpu , Zhang Di , Cao Chengxi , Wang Zhigang , Cui Daxiang , Chen Di
Published: August 2022

Correction for ‘Recent advances in microfluidic-based electroporation techniques for cell membranes’ by Fei Wang et al., Lab Chip, 2022, 22, 2624–2646, https://doi.org/10.1039/D2LC00122E.
Bacterial outer membrane vesicles and their functionalization as vehicles for bioimaging, diagnosis and therapy
Authors: Xue Kaikai , Wang Lu , Liu Jinyao
Published: August 2022

In this review, we summarize the bioactivities of bacterial outer membrane vesicles, including biogenesis, immunogenicity, and interactions, followed by a discussion on their functionalization as nanocarriers for bioimaging, diagnosis, and therapy.
Template-free formation of oriented oxide nanowalls via topotactic-like pseudomorphic transformation: [110]-MgO(111) nanowall arrays
Authors: Shinagawa Tsutomu , Izaki Masanobu
Published: August 2022

The template-free formation of oriented MgO nanowall arrays is successfully achieved by a two-step synthesis route of (i) electrodeposition of vertically aligned hydroxide and (ii) its topotactic-like pseudomorphic transformation to oxide.
Carborane clusters increase the potency of bis-substituted cyclam derivatives againstMycobacterium tuberculosis
Authors: Smith Nicholas , Quan Diana , Nagalingam Gayathri , Triccas James A. , Rendina Louis M. , Rutledge Peter J.
Published: August 2022

Bis-substituted cyclam derivatives have recently emerged as a promising new class of antibacterial agents, displaying excellent activity against drug-resistantMycobacterium tuberculosis(Mtb). Carborane pendants enhance this activity.
Cyclic polymers: synthesis, characteristics, and emerging applications
Authors: Chen Chaojian , Weil Tanja
Published: August 2022

This Review highlights recent advances in the synthesis, unique properties, and most prominent applications of cyclic polymers, and discusses the major challenges and future opportunities in this field.
A lanthanide nanocomposite with cross-relaxation enhanced near-infrared emissions as a ratiometric nanothermometer
Authors: Hu Qian , Kong Na , Chai Yingjie , Xing Zhenyu , Wu Yukai , Zhang Jieying , Li Fuyou , Zhu Xingjun
Published: August 2022

Lanthanide-doped nanocomposite is established as a dual-ratiometric luminescence nanothermometer. The cross-relaxation processes can efficiently enhance near infrared emissions and induce a temperature response of the emissions.
Influence of cationic groups on the antibacterial behavior of cationic nano-sized hyperbranched polymers to enhance bacteria-infected wound healing
Authors: Xue Yunyun , Zhao Zihao , Zhao Yu , Wang Chuyao , Shen Shuyang , Qiu Zelin , Cui Ronglu , Zhou Shien , Fang Lifeng , Chen Zhi , Zhu Haihong , Zhu Baoku
Published: August 2022

CNHBPs bearing quaternary ammonium salt groups and long alkyl chains exerted the highest antimicrobial activity and low toxicity.
Micellar drug delivery vehicles formed from amphiphilic block copolymers bearing photo-cross-linkable cyclopentenone side groups
Authors: Stouten Jules , Sijstermans Nick , Babilotte Joanna , Pich Andrij , Moroni Lorenzo , Bernaerts Katrien V.
Published: August 2022

UV core cross-linkable amphiphilic block copolymers containing cyclopentenone side groups on the hydrophobic backbone were synthesized and drug delivery experiments were done with the cancer therapeutic drug Doxorubicin.
Improved electrode kinetics of a modified Na3V2(PO4)3 cathode through Zr substitution and nitrogen-doped carbon coating towards robust electrochemical performance at low temperature
Authors: Li Jiabao , Li Ziqian , Tang Shaocong , Hao Jingjing , Wang Tianyi , Wang Chengyin , Pan Likun
Published: August 2022

The substitution of V with Zr in a NASICON structure and an NC coating endow 0.1Zr-NVP/NC with excellent electrochemical performance at low temperature.
Achieving the highest density and energy within diazo-oxide compounds
Authors: Ding Ning , Sun Qi , Zhao Chaofeng , Zhang Wenjin , Li Shenghua , Pang Siping
Published: August 2022

Pushing the density and energy limits of diazo-oxide compounds through the introduction of trinitromethyl group.
Visible-light-induced transition-metal-free defluorosilylation of α-trifluoromethylalkenes via hydrogen atom transfer of silanes
Authors: Xu Wengang , Xia Congjian , Shao Qi , Zhang Qiao , Liu Mingrui , Zhang Hongwei , Wu Mingbo
Published: August 2022

A green and feasible synthetic protocol for silyl gem-difluoroalkenes was developed using α-trifluoromethylalkenes and silanes via the synergistic combination of photoredox and hydrogen-atom transfer catalysis under visible light irradiation.
Nickel(ii)/TPMPP catalyzed reductive coupling of oxalates and tetrasulfides: synthesis of unsymmetric disulfides
Authors: Chen Ying , Sheng Daopeng , Wang Fei , Rao Weidong , Shen Shu-Su , Wang Shun-Yi
Published: August 2022

A Ni(ii)/TPMPP-catalyzed reductive cross-coupling reaction of benzyl oxalates and tetrasulfides to synthesize unsymmetric disulfides is reported.
Synthesis and bioimaging of a BODIPY-based fluorescence quenching probe for Fe3+
Authors: Leng Junqiang , Lan Xinyu , Liu Shuang , Jia Wenxuan , Cheng Wenshuai , Cheng Jianbo , Liu Zhenbo
Published: August 2022

A quenched fluorescence probe sensitive to Fe3+ ions was synthesized. The probe was successfully used to detect Fe3+ in living organisms.
Reusable alcohol oxidase–nPtCu/alginate beads for highly sensitive ethanol assay in beverages
Authors: Stasyuk Nataliya , Demkiv Olha , Gayda Galina , Zakalska Oksana , Zakalskiy Andriy , Serkiz Roman , Kavetskyy Taras , Gonchar Mykhailo
Published: August 2022

Novel colorimetric method based on alginate beads encapsulated with nPtCu and alcohol oxidase have been developed and optimized.
Distributions and sources of traditional and emerging per- and polyfluoroalkyl substances among multiple environmental media in the Qiantang River watershed, China
Authors: Liu Zhengzheng , Zhou Jingqing , Xu Yalu , Lu Jiafeng , Chen Jinyuan , Wang Jing
Published: August 2022

The presence of per- and polyfluoroalkyl substances (PFASs) in the food chain poses a threat to human health.
Determination of furfurals in baby food samples after extraction by a novel functionalized magnetic porous carbon
Authors: Davari Seyedeh Dorsa , Rabbani Mohammad , Basti Afshin Akhondzadeh , Koohi Mohammad Kazem
Published: August 2022

Herein, a novel polypyrrole-polyaniline functionalized magnetic porous carbon (MPC@PPy- PANI) composite material was fabricated and utilized for the separation/extraction of furfurals from baby food and dry milk samples.
Novel extraction route of lithium from α-spodumene by dry chlorination
Authors: Fosu Allen Yushark , Kanari Ndue , Bartier Danièle , Vaughan James , Chagnes Alexandre
Published: August 2022

Processing spodumene for lithium is challenging as it requires a high temperature transformation of the natural α-monoclinic form to β-tetragonal form, usually followed by acid baking and digestion.
Development of nitrile rubber/eucommia ulmoides gum composites for controllable dynamic damping and sound absorption performance
Authors: Su Lin , Wang Qi , Xiang Ping , Yin Dexian , Ding Xiaodong , Liu Li , Zhao Xiuying
Published: August 2022

Nitrile rubber (NBR)/Eucommia ulmoides gum (EUG) composites were successfully fabricated with controllable dynamic damping and sound absorption performances, owing to the changeable EUG crystal number in different NBR/EUG composites.
Electrochemical performance of CoSe2 with mixed phases decorated with N-doped rGO in potassium-ion batteries
Authors: Zheng Hui , Xu Han-Shu , Hu Jiaping , Liu Huimin , Wei Lianwei , Wu Shusheng , Li Jin , Huang Yuhu , Tang Kaibin
Published: August 2022

Potassium-ion batteries (PIBs) have received much attention as next-generation energy storage systems because of their abundance, low cost, and slightly lower standard redox potential than lithium-ion batteries (LIBs).
Phase behavior of binary and ternary fluoropolymer (PVDF-HFP) solutions for single-ion conductors
Authors: Kim Jung Yong
Published: August 2022

A fluoropolymer poly(vinylidene fluoride-co-hexafluoropropylene) (PVDF-HFP) has a dielectric constant of ∼11, providing charge screening effects.
On the electrocatalytical oxygen reduction reaction activity and stability of quaternary RhMo-doped PtNi/C octahedral nanocrystals
Authors: Hornberger Elisabeth , Klingenhof Malte , Polani Shlomi , Paciok Paul , Kormányos Attila , Chattot Raphaël , MacArthur Katherine E. , Wang Xingli , Pan Lujin , Drnec Jakub , Cherevko Serhiy , Heggen Marc , Dunin-Borkowski Rafal E. , Strasser Peter
Published: August 2022

PtNi nano-octahedra with Rh and Mo dopants are highly active catalysts for the oxygen reduction reaction with excellent stability and shape integrity. We investigate the morphological, structural, and compositional evolution during stability testing.
Flexible methanol and hydrogen production from biomass gasification with negative emissions
Authors: Poluzzi Alessandro , Guandalini Giulio , Romano Matteo C.
Published: August 2022

Multi-product plants with CCS maximize carbon utilization and may obtain economic advantages from flexible production of H2 and methanol.
The rational inclusion of vitamin B6boosts artificial cobalt complex catalyzed green H2production
Authors: Mir Ab Qayoom , Saha Sukanta , Mitra Sampurna , Guria Somnath , Majumder Piyali , Dolui Dependu , Dutta Arnab
Published: August 2022

Electrocatalytic and photocatalytic H2production from water with a vitamer appended synthetic catalyst.
A highly efficient and stable platinum film deposited via a mixed metal-imidazole casting method as a benchmark cathode for electrocatalytic hydrogen evolution
Authors: Zahran Zaki N. , Mohamed Eman A. , Katsuki Tomohiro , Tsubonouchi Yuta , Chandra Debraj , Hoshino Norihisa , Yagi Masayuki
Published: August 2022

A Pt cathode (Pt(w-MeIm)) prepared by a mixed metal-imidazole casting (MiMIC) method showed a remarkably superior hydrogen evolution reaction (HER) performance compared to the cathode prepared without imidazole (Pt(w/o-MeIm)), and the common Pt-based benchmark cathodes of Pt/C or the Pt plate.
Bell-shaped RuFe/Ni5P4 for efficient urea-assisted electrolytic hydrogen production
Authors: Xu Wenjuan , Zhang Wei , Sun Zejun , Guo Liutao , Xie Liping , Li Chengrui , Feng Yanru , Liang Qionglin , Yang Yang , Sun Hong-bin
Published: August 2022

The self-growing bell-shaped structure of the nickel foam substrate have excellent binding ability with the NF substrate, which greatly improve the mass and charge transfer efficiency and provide the possibility of stabilizing the catalyst at large currents.
Edge-state-induced magnetism in two-dimensional hematene
Authors: Shi Junjie , Ren Weiwei , Ren Xiaoyan , Shang Yuanyuan , Pang Rui , Li Shunfang
Published: August 2022

The row-wise spin arrangement and edge state make hematene ribbons with width of odd numbers of atoms show magnetic order near room temperature.
Correction: Selective sacrificial metal–organic frameworks: a highly quantitative colorimetric naked-eye detector for aluminum ions in aqueous solutions
Authors: Rouhani Farzaneh , Rafizadeh-Masuleh Fatemeh , Morsali Ali
Published: August 2022

Correction for ‘Selective sacrificial metal–organic frameworks: a highly quantitative colorimetric naked-eye detector for aluminum ions in aqueous solutions’ by Farzaneh Rouhani et al., J. Mater. Chem. A, 2019, 7, 18634–18641, https://doi.org/10.1039/C9TA03647D.
Lead-free double perovskites: how divalent cations tune the electronic structure for photovoltaic applications
Authors: Ibrahim Ismail A. M. , Chung Chan-Yeup
Published: August 2022

The tunability of the electronic structure and the optical performance of Cs2AgSbCl6 double perovskite for photovoltaic applications is shown via Sn2+ and Ge2+ doping as a consequence of the dopant orbital contribution at the band edges.
SMDAF: A novel keypoint based method for copy‐move forgery detection
Authors: Yue Guangyu , Duan Qing , Liu Renyang , Peng Wenyu , Liao Yun , Liu Junhui
Published: August 2022

Copy–move forgery poses a significant threat to social life and has aroused much attention in recent years. Although many copy‐move forgery detection (CMFD) methods have been proposed, the most existing CMFD methods are short of adaptability in detecting images, which leads to the limitation on detection effects. To solve this problem, the paper proposes a novel keypoint‐based CMFD method: second‐keypoint matching and double adaptive filtering (SMDAF). Motivated by image matching based on keypoint, the second‐keypoint matching method is designed to match keypoints extracted from copy–move forgery images, which can be used for both the single‐CMFD and the multiple‐CMFD. Then, a double adaptive filter (DAF) based on the AdaLAM algorithm and the KANN‐DBSCAN clustering algorithm to filter wrong keypoint matches adaptively are proposed, according to the distinct distribution of keypoints in each image. Finally, the forgery regions are presented by finding their convex hulls and padding them. Compared with existing methods, extensive experiments show that the SMDAF method significantly provides more efficiency in detecting images under simulated real‐world conditions, has better robustness when facing images with different post‐treatment attacks, and is more effective in distinguishing images that look copy–move forged but are real.
White-light QFP wave train and the associated failed breakout eruption
Authors: Shen Yuandeng , Yao Surui , Tang Zehao , Zhou Xinping , Qu Zhining , Duan Yadan , Zhou Chengrui , Tan Song
Published: August 2022

Quasi-periodic fast-propagating (QFP) magnetosonic wave trains are commonly observed in the low corona at extreme ultraviolet wavelength bands. Here, we report the first white-light imaging observation of a QFP wave train propagating outwardly in the outer corona ranging from 2 to 4R⊙. The wave train was recorded by the Large Angle Spectroscopic Coronagraph on board the Solar and Heliospheric Observatory (SOHO), and was associated with a GOES M1.5 flare in NOAA active region AR12172 at the southwest limb of the solar disk. Measurements show that the speed and period of the wave train were about 218 km s−1and 26 min, respectively. The extreme ultraviolet imaging observations taken by the Atmospheric Imaging Assembly on board the Solar Dynamic Observatory reveal that in the low corona the QFP wave train was associated with the failed eruption of a breakout magnetic system consisting of three low-lying closed loop systems enclosed by a high-lying large-scale one. Data analysis results show that the failed eruption of the breakout magnetic system was mainly because of the magnetic reconnection that occurred between the two lateral low-lying closed-loop systems. This reconnection enhances the confinement capacity of the magnetic breakout system because the upward-moving reconnected loops continuously feed new magnetic fluxes to the high-lying large-scale loop system. For the generation of the QFP wave train, we propose that it could be excited by the intermittent energy pulses released by the quasi-periodic generation, rapid stretching, and expansion of the upward-moving, strongly bent reconnected loops.