bluuebunny/crossref_metadata_2025 huggingface dataset:
Luminescent Au-Ag nanoclusters entrapped in protein matrix: Conditions of sample maturing influencing Au-Ag synergistic effect
Authors: Svačinová Veronika , Pluháček Tomáš , Petr Martin , Šišková Karolína
Published: January 2024

Gold-silver synergism has been well documented in many scientific works already. Frequently, the ratio of Au : Ag in synthetic mixtures was varied to influence the extent of Au-Ag synergism. However, in our approach, a new step, maturing (under differing conditions) of the luminescent bimetallic samples entrapped in a protein, has been introduced and applied for the very first time. The maturing conditions involved either prolonged time (2.5h vs. 0 min) and/or elevated temperature (50 °C vs. room temperature). The prolonged time of samples maturing progressively influenced Au-Ag synergism (documented by fluorescent quantum yield increase); while elevated temperature during samples maturing led rather to changes of the protein secondary structure (determined by circular dichroism) and stagnation of Au-Ag synergism effect. Importantly, the selected maturing conditions led to significant increase of nanocluster sizes and broadening of particle size distribution as evidenced by scanning transmission electron microscopy (STEM) and dynamic light scattering (DLS). The results unravel that Au-Ag synergism can be tuned by setting appropriate maturing conditions of bimetallic nanoclusters embedded in the protein scaffold.
Short-term effects of the Strengthening Families Program (SFP 10-14) in Brazil: a randomized controlled trial
Authors: Sanchez Zila M , Valente Juliana Y , Gubert Fabiane A , Galvão Patricia P O , Cogo-Moreira Hugo , Rebouças Lidiane N , Santos Miguel Henrique S dos , Melo Marcia H S , Caetano Sheila C
Published: January 2024

This study discloses the evaluation of the short-term effect of the Strengthening Families Program (SFP 10-14), adapted as Famílias Fortes (Strong Families) in Brazil, on preventing adolescent drug use and improving parenting behaviors.
Methods: A two-arm, parallel cluster randomized controlled trial was conducted in 60 Social Assistance Reference Centers (SARC) in 12 Brazilian municipalities. In each city, the SARC were randomly assigned to the intervention or control group. Eight hundred five families participated in the study, each contributing data from one parent/guardian and one adolescent for a total of 1,610 participants. Data collection occurred before the implementation of the intervention, and 6 months after baseline collection. Data were analyzed using multilevel mixed-effects modeling with repeated measuresin two different paradigms: Intention to Treat (ITT) and Per protocol (PP). The study was registered in the Brazilian Ministry of Health Register of Clinical Trials (REBEC), under protocol number RBR-5hz9g6z.
Results: Considering the ITT paradigm, the program reduced the chance of parents/guardians being classified as negligent by 60% (95%CI 0.21; 0.78); increased the use of nonviolent discipline by caregivers (Coef 0.33, 95%CI 0.01; 0.64) and decreased the chance of adults exposing adolescents to their drunken episodes by 80% (95%CI 0.06; 0.54). No program effects were observed on outcomes related to adolescent drug use. Similar results were observed in the PP paradigm.
Conclusion: The positive results on family outcomes suggest preventive potential of the program in the Brazilian population. Long-term evaluations need to be conducted to verify if the program will also achieve the drug use reduction goals that were not found in the short term.
Correlation Between Early Postnatal Body Weight Changes and Lung Ultrasound Scores as Predictors of Bronchopulmonary Dysplasia in Preterm Infants; A Secondary Analysis of a Prospective Study
Authors: Ghanem Mohab , Zozaya Carlos , Ibrahim Jenna , Lee Seungwoo , Mohsen Nada , Nasef Nehad , Mohamed Adel
Published: January 2024

Purpose of the study: Recent research links Early Weight-Changes (EWC) with bronchopulmonary dysplasia (BPD) in preterm neonates, while lung ultrasound score (LUS) has shown promise in predicting BPD. We aimed to explore the correlation between LUS and EWC as markers of extravascular lung edema.
Objective: To investigate the correlation between LUS and EWC in preterm infants with respiratory distress syndrome regarding future BPD development.
Methods: This secondary analysis of a prospective study involved infants ≤ 28 weeks' gestation. Enrolled infants underwent lung ultrasound assessment on postnatal days 3, 7 and 14, measuring LUS. Respiratory severity score (RSS) and EWC were computed on the same time-points. Infants were classified as either having BPD or not. Descriptive statistics, Correlation Coefficient, and Area Under the Receiver Operating Characteristic Curve (AUROC) analysis were utilized.
Results: Of 132 infants, 70 (53%) had BPD. Univariate analysis revealed statistically significant differences in LUS, EWC, and RSS at days 3, 7, and 14 between BPD and no-BPD groups (p < 0.001). A statistically significant but weak positive correlation existed between LUS and EWC at all three assessment points. AUROC analysis indicated LUS having superior predictive capacity for the need for invasive mechanical ventilation at day 14 as well as the later BPD development compared to EWC (p < 0.0001).
Conclusions: In a cohort of extreme preterm infants, our study revealed a positive yet weak correlation between LUS and EWC, suggesting that EWC was not the major contributing to the evolving chronic lung disease.
Sol-Gel Assisted β-Cyclodextrin Coated MoO3-Fe2O3 Nanocomposite for Photodegradation of Methylene Blue Dye
Authors: Nagare Akash , Dhadage Amol , Baithy Mallesham , Bhuyan Priyanga Manjuri , Gogoi Parikshit , Athare Anil , Navgire Madhukar
Published: January 2024

In this work, series of β-Cyclodextrin coated MoO3-Fe2O3 nanocomposites were successfully synthesized by using the sol-gel technique to improve their optical properties with the photocatalytic activity of Fe2O3. The prepared materials were analyzed by using various characterization techniques like powder XRD, FT-IR, UV-DRS, FE-SEM, HR-TEM, RAMAN, BET, and XPS. The X-ray diffraction spectra analyzed that, it shows the nanocrystalline nature of synthesized materials. The indirect allowed transition optical energy band gap of nanocomposites is lies between 2.67 to 1.71 eV. The FE-SEM study revealed the nano-flakes to change occurs in the morphology of nanocomposites sample also it gives estimated size in between 30–50 nm. The BET analysis show mesoporous nature of nanocomposites and XPS spectra shows the elemental composition on surface of the synthesized sample. The proficiency of the nanocomposites was tested for the photodegradation of the methylene blue dye (MB) under sunlight at room temperature (25°C) in presence of H2O2. The pure MoO3 and Fe2O3 material gives 38.21% and 77.10% photodegradation of MB respectively. In series lies between 5% β-Cyclodextrin coated MoO3-Fe2O3 (5βMF) shows excellent photocatalytic activity which degrades 91.62% of MB at neutral pH. Thus, the photodegradation reaction is effectively attributed to charge carrier separation and reduced optical band gap energy due to enhanced photocatalytic activity.
Local Wisdom on Mangrove Management in Nipah Panjang Village, Indonesia
Authors: Fariz Trida Ridho , Permana Pawit Indra , Jabbar Abdul , Saoki Rafi Nadhifa , Purwadi Cintiya Egi
Published: January 2024

Indonesia is one of the countries that has the largest mangrove forest area. Although Indonesia is a country that has the largest mangrove forest in the world, several problems have caused the reduction of mangrove forest areas, so it requires strategic policies. Strategic mangrove management policies will be more easily applied in the community based on local wisdom in the region so that this study will discuss local wisdom in mangrove management in Nipah Panjang Village. This study is qualitative, with data collection using literature studies, interviews, and observations. This study shows that the existence of mangrove forests provides ecological and economic benefits for the people of Nipah Panjang Village. The economic benefit is that mangrove forests provide food and shelter for bees and Kelulut, which the community utilizes for honey. The cultivation process also has local wisdom values that aim to preserve mangrove forests, especially in forest honey cultivation. If mangrove forests are damaged, it will result in honey production, leading to the loss of community livelihoods. For this reason, it is necessary to make efforts to conserve mangroves.
Bibliometric Analysis of the Intersection Between Digital Libraries and Technology in Public Library Services: A Scopus Review (2021-2023)
Authors: Islam Md. Nurul , Haider Mohammad Sohail
Published: January 2024

This paper meticulously reviews research spanning 2021–2023 in digital public library technology. Analyzing 1,626 documents from 753 sources, it uncovers key trends. Despite a -19.59% annual growth rate, collaboration is robust, with 2.71 co-authors per document and 15.31% international collaborations. Fluctuating scientific production and citation metrics raise questions about research impact. Keyword analysis reveals multidimensionality, while identifying influential sources, authors, and globally cited documents. The global landscape analysis underscores broad participation, emphasizing connectivity and evolving research trends. This comprehensive analysis provides a nuanced understanding, guiding future exploration for deeper insights.
Disulfidptosis-related Long Non-Coding RNA signature predicts the prognosis, tumor microenvironment, immunotherapy, and antitumor drug options in colon adenocarcinoma
Authors: Wang Kang , Yu Jing , Xu Qihuan , Peng Yuanhong , Li Haibin , Lu Yan , Ouyang Manzhao
Published: January 2024

This study aims to investigate the role and prognostic significance of long non-coding RNAs (lncRNAs) associated with disulfidptosis in colon adenocarcinoma (COAD). The TCGA database's clinical data and transcriptome profiles were employed. Analysis of previous studies identified 10 disulfidptosis-related genes (DRGs). We used these genes to construct a signature that could independently and accurately predict the prognosis of patients with COAD. The Kaplan-Meier (K-M) curve analysis showed that the lower-risk group had a better prognosis. With the help of multivariate Cox regression analysis, the risk score produced from the patient's signature might independently predict the outcomes. Utilizing a nomogram, the receiver operating characteristic (ROC) curve, and principal component analysis (PCA), the signature's predictive ability was also confirmed. It's interesting to note that immunotherapy, especially PD-1 immune checkpoint suppression, was more likely to benefit low-risk patients. The IC50 levels for certain anticancer agents were lower in the high-risk group. Finally, qRT-PCR analyses in colon cancer cell lines revealed elevated levels of lncRNAs CASC9, ZEB1-AS1, ATP2A1-AS1, SNHG7, AL683813.1, and AP003555.1, and reduced levels of FAM160A1-DT and AC112220.2, compared to normal cell lines. This signature offers insights into prognosis, tumor microenvironment, and options for immunotherapy and antitumor drugs in patients with COAD.
Spatiotemporal Analysis Land Use Land cover changes in South Kashmir Region of North-western Himalayas Using Landsat data
Authors: Mushtaq Shaista , Saleem Shahid , Ahmed Rayees , Rather Javeed A , Rather G. M.
Published: January 2024

This paper presents a comprehensive analysis of land use changes in South Kashmir from 2000 to 2022, revealing significant transformations in various land cover classes. Leveraging remote sensing and geographic information systems (GIS), the study examines the spatial patterns and temporal dynamics of land use and land cover, offering valuable insights into the region's landscape dynamics. Using supervised classification techniques, satellite imagery was analyzed to identify 10 major land use classes. The findings demonstrate notable increases in horticulture and built-up areas, accompanied by declines in agricultural land, glaciers and snow, exposed rock, and water bodies. The expansion of horticultural lands, covering approximately 7% of the study area, has been attributed to the conversion of agricultural lands. This shift, coupled with the encroachment of settlements to accommodate the growing human population, has resulted in a substantial loss of approximately 757 km2 of farmland agriculture, representing a total percentage change of about 13% during the study period. The implications of these changes extend beyond the local region, highlighting the urgent need for comprehensive and sustainable solutions to address human-induced challenges at a global scale. Furthermore, the study underscores the cost-effectiveness and efficacy of geospatial technologies in conducting spatiotemporal analyses and formulating evidence-based policies for the sustainable management of natural resources. The insights gained from this study offer a solid foundation for informed decision-making and the development of targeted land management strategies in South Kashmir and other similar regions facing similar challenges.
Morphological and molecular identification of Euclinostomum heterostomum in the spotted snakehead (Channa punctata) in Narayanganj, Bangladesh
Authors: Bari Sayed Mashequl , Amina Aktia , Nadia Zubyda Mushtari , Shawon Raf Ana Rabbi , Rahman Md. Matiur , Habib Kazi Ahsan
Published: January 2024

Parasites of the Clinostomidae family are widely distributed worldwide. Freshwater fish of Bangladesh frequently serve as hosts for various Clinostomidae species. The metacercariae stage of Euclinostomum heterostomum, a prevalent digenetic trematode, exhibits a distinct affinity for infecting Channidae species and becomes encysted within the liver, kidneys, and muscles of these species. This study focused on identifying E. heterostomum in Channa punctata using a combination of morphological and molecular approaches. The morphological characteristics of the species were examined using both light and scanning electron microscope. Encysted flukes, inflammatory infiltrates of leukocytes, along with degeneration and loosening of hepatic tissue were observed in the histopathological examination of the infected liver tissue. Molecular analysis of the partial nuclear ribosomal internal transcribed spacer (ITS rDNA) sequence confirmed the presence of Euclinostomum heterostomum. A comparison of the collected metacercariae sequence (Accession no. OR591452) with the NCBI GeneBank databases found similarity to other species within the same genus in India and Thailand. The phylogenetic reconstruction provided compelling evidence of genetic similarity among different strains of the genus Euclinostomum, indicating their shared genetic heritage.
Mix Design Procedure for M30 Grade of Fly Ash Based Geopolymer Self Compacting Concrete
Authors: S.Naresh
Published: January 2024

The total world knows about the importance of concrete because it is a major construction material and we know that what are the ingredients in the concrete, the cement is bonding material in the future the high use of cement will create problems because natural resources like limestone get depleted and limestone occupies 60 to 65% of cement and other hand fly ash is creating different types problems for environmental to reducing this all problems some of the researchers are creating geopolymer concrete as solution for all this problems and for this geopolymer concrete mix design procedure are available and other hand we know that importance of self compacted concrete and its usage. The IS 10262-2019, European guidelines by EFNARC are providing guidelines for mix design of self compacted concrete but till now no one is provided guidelines for M30 Grade of Fly Ash Based geopolymer Self Compacting Concrete so here in this paper we will briefly study the guidelines for mix design of Fly Ash Based geopolymer Concrete and also mix design guidelines for self compacted concrete and merge these two guidelines and will provide guidelines for M30 Grade of Fly Ash Based geopolymer Self Compacting Concrete.
Heat-tolerant Lettuce Germplasm (Lactuca sativa L.) Identified in Romaine and Butterhead Types for Warmer Plantings
Authors: Sandoya Germán , Lafta Abbas , Mou Beiquan
Published: January 2024

Warmer temperatures during crop production are not desirable for a cool-season crop such as lettuce (Lactuca sativa L.). Lettuce is among the top 10 most consumed vegetables in the United States. Production of this vegetable is concentrated mostly in temperate areas of California, and during the wintertime in Arizona and Florida as a result of their mild climatic conditions. Heat-tolerant cultivars are needed for the leafy vegetable industry to continue thriving. However, there is very little information on heat-tolerant germplasms of lettuce that can be used as a source to improve heat tolerance in lettuce. This is particularly important in romaine and butterhead lettuce, which are two morphological types with increasing demand in the market. Therefore, research was conducted to identify germplasm that performs acceptably in warmer regions in the western United States. This investigation also aimed to understand the reaction of varieties to different environments, which could help plant breeders select and evaluate lettuce plants during the breeding process. Twenty-three and 25 accessions of romaine and butterhead lettuce, respectively, were planted in five trials near Holtville, CA, USA: Five Points, CA, USA, under warmer temperatures and Salinas, CA, USA, under cooler temperatures. Romaine genotypes Bambi, Blonde Lente a Monter, Medallion MT, and Red Eye Cos; and butterhead genotypes Butter King and Margarita had no bolting, an acceptable head weight, short cores, and acceptable head height. Head weight and related traits (including core length, height, width, etc.) and heat-related disorders were significantly different across multiple experiments, indicating genetic variation. The major component of the phenotypic variation in these experiments was a result of environmental factors. Therefore, plant breeders may still need to evaluate progeny in multiple trials and multiple locations to select heat-tolerant romaine and butterhead lettuce effectively.
Two Eclipses – Contribution to Understanding Nature and Society
Authors: Kovačević Ivan , Sinani Danijel
Published: January 2024

The aim of this paper is to illustrate how a cultural response is shaped by a natural phenomenon. A solar eclipse is, in a sense, a laboratory for humans have no influence on this natural phenomenon and the occurrence of the phenomenon itself, for the most part, has no significant consequences on people. This analysis is focused on two solar eclipses that occurred in Belgrade on February, 15th 1961 and on August, 11th 1999. The behavior of the citizens during these eclipses was entirely different. In 1961, the citizens curiously observed the eclipse through special glasses or darkened glasses whereas in 1999 they withdrew to their homes, avoiding any contact with the outside world. These contradictory behaviors were influenced by the positive propaganda in 1961 and the panic and fear stricken propaganda induced in 1999, both of which were created by the media under the control of the authorities of the time. Through the analysis of these dissimilar behaviors, as well as different contexts in which they occurred, deeper meanings are discerned, considering both the intentions of the authorities and the citizens' reactions to media propaganda related to these eclipses. It is also observed that there is a certain constant, i.e., each eclipse is closely intertwined with politics, even regarding traditional beliefs about the consequences of an eclipse. It may be concluded that the intrusion of politics into shaping the response to an eclipse is a consequence of the fact that the eclipse is socially consequence-free, so as to say an empty sign suitable for inscribing new meanings that holders of power wish to convey.
Could We Trust Parents? Bioethical Analysis of Biomedical Intervention on Healthy Children
Authors: Mitrović Veselin
Published: January 2024

This text deals with the bioethical analysis of biotechnologies and biomedical interventions for healthy children to achieve a better life for them. The study of such a situation requires that the relationship between respect for autonomy and beneficence should be considered from two perspectives: first, from the perspective of parents as holders of the right to make decisions about the treatment and improvement of their minor children (the principle of respect for autonomy). In that case, parents are guided by the principle of benevolence and paternalistically demand interventions with new bio-medical technologies to make their children's lives better, that is, to improve them. Another approach to the same problem refers to the pressure of children on their parents to provide them with a better life through medical interventions that are increasingly imposed as a social, gender, and aesthetic demand and promoted as an exit of "social suffering," to which individuals who do not meet such requirements are exposed. Bearing in mind both aspects, we analyze the possibility of solving emerging social problems through the potential transfer of the principle of autonomy (owned by parents) to the creditors of the right to make decisions regarding medical interventions for healthy children. Such concerns become particularly relevant given the complexity of the old question: Do parents see their children as an extension of their motives and ambitions? In that case, instead of the decision of the children and the family, an active role in deciding on the implementation of the interventions above should be played by independent professional and ethical commissions, which assess whether the holders of the right to make decisions aim to treat or improve healthy children and that these interventions would be possibly more adequate before some invasive application of biotechnological means.
Women's Activities and the Preservation of Intangible Cultural Heritage in the Gorani Community
Authors: Đorđević Crnobrnja Jadranka
Published: January 2024

Research endeavors within the domain of intangible cultural heritage, conducted within the Gorani community, highlight, among various aspects, the involvement of women in creating and transmitting knowledge and skills, which are perceived by the Gorani populace as a particularly important component of the Gorani tradition. Women are ascribed a key role in preserving Gorani cultural heritage. This study examines the activities of women in the Gorani community within the UNESCO Convention for the Safeguarding of the Intangible Cultural Heritage framework. The research is focused on knowledge, skills, and practices carried out by women, which unfold continually within the Gorani community during the twentieth and twenty-first centuries. It primarily concerns the knowledge and skills of women manifested through the tradition of designing and wearing clothing items, especially those pieces that have become over time an indispensable part of women's ceremonial attire. The empirical data also encourages an examination of the role of women in shaping identity paradigms and symbols in the Gorani community, as well as their expression, transmission, and the assurance of the continuity of these practices. The analysis of women’s contribution to safeguarding the intangible cultural heritage of the Gorani community indicates that the preservation and protection of Gorani tradition, as understood and recognized by the participants in accordance with the UNESCO Convention defining heritage, are conditioned by the social, economic, and political circumstances shaping daily activities and everyday lives of the people in Gora, both within and beyond their native local environment. It is also obvious that Gorani’s interest in their own intangible cultural heritage is unmistakable, as demonstrated by social and cultural practices that would be impracticable without the existence of this heritage. The Gorani people's aspiration to safeguard their own cultural heritage is viewed in the context of its contribution to the preservation and continuity of the Gorani identity, namely the identity of the Gorani community, which holds minority status in the Republic of Serbia.
Improving technology for manufacturing casting case of truck clutch release cylinder
Authors: Demin Dmitriy
Published: January 2024

The object of research: Manufacturing technology of body castings for trucks using the example of a clutch release cylinder body made of gray cast iron with flake graphite EN-GJL-200.

Investigated problem: Finding ways to reduce the weight and size characteristics of cast parts.

The main scientific results: A mathematical model has been developed that has made it possible to determine the optimal compositions of alloying Cr/Ni – Cu/Ti complexes that ensure an increase in the grade of cast iron by increasing the tensile strength at elevated carbon contents. This makes it possible in the future to reduce the thickness of the walls of the castings, achieving a reduction in their weight and size characteristics

The area of practical use of the results of the study: Automotive industry in terms of technology for manufacturing cast parts for trucks

Innovative technological product: Improved technology for manufacturing the clutch release cylinder body due to optimization of melt technology and out-of-furnace processing allows for targeted selection of melt processing modes, ensuring an increase in the strength characteristics of cast iron for cast body parts, thereby moving from the EN-GJL-200 cast iron grade to the EN grade -GJL-250 and EN-GJL-300.

The scope of the innovative technological product: Foundries of engineering enterprises, in particular those producing trucks, in which iron castings are produced
The impact of innovation and fintech on the banking business
Authors: Khudolii Yuliia , Hlushko Alina
Published: January 2024

The object of research. The study analyzes the impact of fintech innovations on the effectiveness of the functioning of the banking business and outlines the prospects for their further implementation in Ukraine, taking into account the EU experience.

Investigated problem. In the conditions of the spread of digitalization processes as a key factor of competitive advantages, the question of researching the introduction of fintech innovations into the banking sector of Ukraine, determining their impact on the effectiveness of the functioning of the banking business, and delineating further prospects for the digitalization of banking institutions' activities becomes relevant.

The main scientific results. The results of the study proved the existence of potential opportunities for expanding the innovative activity of the banking system of Ukraine. In recent years, there has been an intensification of the processes of digitalization of banking services. On the basis of a comparative analysis of the neobanks of Ukraine, their main advantages are outlined and prospective areas of activity expansion are substantiated. At the same time, problematic aspects in the implementation of digital technologies in the banking sector of Ukraine are identified, in particular, imperfect legislation in the field of digital technologies in neobanking and licensing of their activities, low level of financial literacy of the population, expensive initial investments. This requires further research into the possibilities of implementing the positive experience of the EU countries.

The area of practical use of research results. The results of the study can be used by banking institutions of Ukraine when justifying strategies for introducing fintech into their activities.

Innovative technological product. The results of the study made it possible to outline strategic directions for the introduction of digital technologies in the banking sector of Ukraine.

Scope of the innovative technological product. The results of the research concern the implementation of banking innovations.
Reklamlarda Ünlü Kullanımının Satın Alma Niyetine Etkisinde Etnikmerkezciliğin Düzenleyici Rolü: Türk Hava Yolları Örneği (The Moderating Role of Ethnocentrism in The Effect of Celebrity Endorsement on Purchase Intention: The Case of Turkish Airlines)
Authors: HAFÇI YORULMAZ Büşra , ÖNCÜER Melek Ece
Published: January 2024

Geleneksel kitle iletişim araçlarından biri olan televizyon, kitlelere ulaşabilmek isteyen işletmeler için önemli bir araçtır. Televizyon reklamlarının etkililiğinde öne çıkan uygulamalardan biri de reklamlarda ünlü kullanımıdır. Tüketici etnikmerkezciliği ise, bireyin ait olduğu toplumu üstün görme eğilimidir. Bu çalışmada, reklamlarda ünlü kullanımı stratejisinin bireylerin satın alma niyetleri üzerindeki etkisini ve bu ilişkide etnikmerkezcilik kavramının rolünü belirlemek amaçlanmıştır. Çalışma, Türk Hava Yolları televizyon reklamlarında yer alan ünlüleri konu edinerek 18 yaş üstü, daha önce en az bir kez Türk Hava Yolları ile uçak seyahati gerçekleştirmiş Türk vatandaşları üzerinde yürütülmüştür. Çalışma, nicel ve nitel olmak üzere karma bir yöntem üzerine kurulmuştur. Nitel veriler bir odak grup görüşmesi ve bir yarı yapılandırılmış derinlemesine mülakat aracılığıyla elde edilmiş ve kodlama yöntemi ile analiz edilmiştir. Nicel veriler ise, 404 geçerli anket formundan elde edilmiş ve tanımlayıcı istatistiki analizler, güvenilirlik analizi, keşfedici ve doğrulayıcı faktör analizi ile yapısal eşitlik modeli aracılığıyla yorumlanmıştır.
Profesyonel Turist Rehberlerinin Pandemi Sürecinde İşini Kaybetme Kaygısının İş Performansına Etkisi (The Effect of Professional Tourist Guides Anxiety of Losing Their Jobs During the Pandemic Process on Job Performance)
Authors: GÜMÜŞ Gökhan , ŞAHBAZ R. Pars
Published: January 2024

Pandeminin etkisiyle ortaya çıkan rezervasyon iptalleri, turistik faaliyetlerde görevli profesyonel turist rehberlerinin iş kaybı ve işsizlik endişesine yol açtığı gibi, sağlık kaygısı, motivasyon eksikliği ve düşük performans gibi bir dizi problemi de beraberinde getirmiştir. Bu çalışmanın temel amacı, COVID-19 pandemisinin neden olduğu iş kaybı endişesinin profesyonel turist rehberlerinin iş performansı üzerindeki etkilerini araştırmaktır. Bu kapsamda, literatürde güvenilirliği ve geçerliliği test edilmiş ölçeklerden derlenen bir anket formu oluşturulmuştur. Anket formu, Nevşehir Turist Rehberleri Odası'na kayıtlı 401 turist rehberine yüz yüze ve Google form aracılığıyla uygulanmıştır. Hipotezler, Varyans Analizi, bağımsız örneklem t-testi ve regresyon analizi kullanılarak test edilmiştir. Bulgulara göre, katılımcıların medeni durumları, COVID-19 durumları ve bulaştırma endişeleri ile iş performansı arasında anlamlı farklılık bulunmazken, cinsiyet, yaş, meslek ve çalışma şekli gibi faktörlere bağlı olarak değerlendirmelerde farklılıklar ortaya çıkmıştır. İş güvencesizliği algısı ile iş performansı arasında düşük düzeyde pozitif bir ilişki belirlenmiştir. Katılımcıların pandemi nedeniyle iş güvencesizliği algıları arttıkça, iş performansındaki etkinin de düşük düzeyde paralel olarak arttığı görülmüştür.
Arrangement of nearby minima and saddles in the mixed spherical energy landscapes
Authors: Kent-Dobias Jaron
Published: January 2024

The mixed spherical models were recently found to violate long-held assumptions about mean-field glassy dynamics. In particular, the threshold energy, where most stationary points are marginal and that in the simpler pure models attracts long-time dynamics, seems to lose significance. Here, we compute the typical distribution of stationary points relative to each other in mixed models with a replica symmetric complexity. We examine the stability of nearby points, accounting for the presence of an isolated eigenvalue in their spectrum due to their proximity. Despite finding rich structure not present in the pure models, we find nothing that distinguishes the points that do attract the dynamics. Instead, we find new geometric significance of the old threshold energy, and invalidate pictures of the arrangement of most marginal inherent states into a continuous manifold.
Factors influencing brand equity: Testing Aaker’s brand equity framework in Malaysian toy industry
Authors: Chee Hoo Wong , Yi Xin Chai , Moosa Visal
Published: January 2024

Previous studies have demonstrated varying associations between fundamental components of brand equity within diverse sectors. The purpose of the current study is to examine the influence of Aaker’s brand equity model’s dimensions (brand awareness, brand loyalty, perceived quality, and brand association) on brand equity in the context of toy brands in Malaysia. The study employs a quantitative-based correlation design within a non-controlled setting, using a cross-sectional approach with individuals as the unit of analysis. The population consists of respondents from the general public aged 18 and above, as they are valid buyers of toys. Data collection was conducted using a non-probability sampling method. The questionnaire was sent to the targeted respondents using online Google Form links. A comprehensive dataset from 384 respondents was gathered for descriptive analysis of the demographic profile. Hypothesis testing was performed using regression analysis. The findings indicate that, except for brand associations, the remaining three factors – perceived quality (Beta = .377, p < .001), brand loyalty (Beta = .338, p < .001), and brand awareness (Beta = .221, p < .01) – exhibit a statistically significant positive correlation with the brand equity of children’s toy brands in Malaysia.
AcknowledgmentThe authors thank INTI International University, Malaysia, for providing financial support to publish this paper.
NECESSIDADE DE DECOLONIZAR O TERMO INOVAÇÃO
Authors: Bianchini Borduque Maria Clara , Segurado Rosemary
Published: January 2024

O termo inovação sofre uma disputa semântica ao longo da história. Em uma análise cronológica, percebe-se que acontecimentos sociais, políticos e econômicos contribuem para tornar, hoje em dia, a inovação uma palavra fetiche. Cristaliza-se uma forte identificação com apenas uma parte dos seus sentidos múltiplos: aquele relativo aos seus aspectos tecnológicos, contribuintes do “progresso” econômico. Porém, paralela à esta “evolução”, o pensamento moderno abissal tratou de inviabilizar outras possibilidades semânticas do termo inovação, que sempre estiveram presentes, e resistiram, de forma quase invisível, a todos esses acontecimentos. Atualmente, em uma releitura decolonial, é possível acesso a uma destas propostas sobreviventes, que questionam a denominação popular do termo, e trazem reflexão.
Transcriptome Sequencing of Gingival Tissues from Impacted Third
Molars Patients Reveals the Alterations of Gene Expression
Authors: Zhou Haolin , Fu Nanqing , Tian Yuan , Zhang Nini , Fan Qin , Zeng Fengjiao , Wang Yueyue , Bai Guohui , Chen Bin
Published: January 2024

Objective:

The removal of impacted third molars by surgery may occur with a series of
complications, whereas limited information about the postoperative pathogenesis is available.
The objective of this study is to identify changes in gene expression after flap surgical removal of
impacted third molars and provide potential information to reduce postoperative complications.

Methods:

The gingival tissues of twenty patients with flap surgical removal of impacted third
molars and twenty healthy volunteers were collected for gene expression testing. The collected
gingival tissues were used RNA sequencing technology and quantitative real-time PCR validation
was performed. DEG was mapped to protein databases such as GO and KEGG for functional
annotation and, based on annotation information, for mining of differential expression genes in
patients with mpacted third molars.

Results:

A total of 555 genes were differentially expressed. Among the top up-regulated genes,
HLA-DRB4, CCL20, and CXCL8 were strongly associated with immune response and signal
transduction. Among the top down-regulated genes, SPRR2B, CLDN17, LCE3D and LCE3E were
related to keratinocyte differentiation, IFITM5, and BGLAP were related to bone mineralization,
UGT2B17 is associated with susceptibility to osteoporosis. KEGG results showed that the DEGs
were related to multiple disease-related pathways.

Conclusion:

This first transcriptome analysis of gingival tissues from patients with surgical removal
of impacted third molars provides new insights into postoperative genetic changes. The
results may establish a basis for future research on minimizing the incidence of complications
after flap-treated third molars.
Acupuncture Combined with Bushen-Jianpi Decoction Ameliorates the
Ovarian Function of Diminished Ovarian Reserve Rats by Regulating
Phosphoinositide 3-Kinase/AKT Signaling
Authors: Lao Jianting , Hu Panwei , Li Jia , Li Jiahui , Zhang Xiaole , Yang Hong , Qi Cong
Published: January 2024

Objective:

This study aimed to explore the therapeutic efficiency as well as mechanism
of acupuncture combined with Bushen-Jianpi decoction (BJD) to treat rats with diminished ovarian
reserve (DOR).

Methods:

A DOR rat model was constructed using zona pellucida 3 peptide, and acupuncture,
BJD, and their combination were administered as therapeutic interventions. We measured changes
in the ovarian indexes, the number of follicles at all levels, the serum levels of sex hormones
and immune factors, the expression levels of phosphoinositide 3-kinase (PI3K), AKT, p-AKT,
and caspase-3, and the changes in the proportions of splenic T cell subtypes, including T-helper
17 (Th17), Tc17, regulatory T (Treg), CD4+, and CD8+ cells.

Results:

Acupuncture combined with BJD induced a decrease in the levels of follicle-stimulating
and luteinizing hormones, and the effect was greater than that elicited by BJD or acupuncture
alone (P < 0.05). Additionally, this combination treatment effectively abrogated the increase in
the levels of interleukin-2 (IL-2), IL-17, anti-zona pellucida antibody, and cleaved caspase-3 (P < 0.05), while promoting the regulation of IL-6 and p-AKT (P < 0.01). Furthermore, treatment with
acupuncture combined with BJD restored the proportions of CD4+ cells and the CD4+ / CD8+ T
cell ratio (P < 0.01), decreased the proportion of CD8+ T and Th17 cells (P < 0.01), and increased
the proportions of Tc17 and Treg cells (P < 0.01).

Conclusion:

Combining acupuncture with BJD can enhance ovarian function in DOR rats. The
regulation of sex hormone levels and immune function in rats may be attributed to the adjustment
of the mRNA and proteins levels of PI3K, AKT, and caspase-3 in the PI3K/AKT signaling pathway,
which leads to an improvement in the immune function of DOR rats.
Histone Deacetylase 2 Stabilizes SPARC-related Modular Calcium Binding 2 to Promote Metastasis and Stemness in Gallbladder Cancer
Authors: Feng Ji , Zheng Xueyong
Published: January 2024

Background:

We aimed to investigate the relationship between histone
deacetylase 2 (HDAC2) and SPARC-related modular calcium binding 2 (SMOC2) and
the role of SMOC2 in gallbladder cancer (GBC).

Methods:

The expression of HDAC2 and SMOC2 in GBC and normal cells was
detected by quantitative real-time reverse transcription polymerase chain reaction
(qRT-PCR), which was also used to detect the mRNA stability of SMOC2. The
combination between HDAC2 and SMOC2 was detected by Chromatin
immunoprecipitation (ChIP) assay. After silencing and/or overexpressing HDAC2 and
SMOC2, cell viability, migration, invasion, and stemness were respectively tested by
the Cell Counting Kit-8 (CCK-8), cell scratch, transwell, and sphere-formation assay.

Results:

In GBC cells, HDAC2 and SMOC2 were highly expressed. HDAC2 combined
with SMOC2 promoted mRNA stability of SMOC2. HDAC2 or SMOC2 overexpression
promoted GBC cell metastasis and stemness. SMOC2 overexpression rescued the
negative effects of silencing HDAC2 in GBC.

Conclusion::

HDAC2 stabilizes SMOC2 to promote metastasis and stemness in
gallbladder cancer.
Human Umbilical Cord Mesenchymal Stem Cells Alleviate Chronic Salpingitis by Modulating Macrophage-Associated Inflammatory Factors
Authors: Liao Wenjuan , Li Xiaomao , Tang Xinrang
Published: January 2024

Introduction:

Mesenchymal stem cells (MSCs) have been widely studied because of
their established anti-inflammatory properties. During chronic salpingitis (CS), infiltrated
macrophages have vital roles in inflammation and tissue remodeling.

Methods:

We employed the type of MSCs, human umbilical cord (huc) MSCs in an experimental
CS model and therapeutic efficacy was assessed. hucMSCs exerted this therapeutic effect by regulating
macrophage function. To verify the regulatory effects of hucMSCs on the macrophage,
macrophage line RAW264.7 markers were analyzed under LPS stimulation with or without co-culturing
with hucMSCs for 12h and 24h. In addition, flow cytometry analysis was applied to reveal
the interaction of co-culture. For animal studies, CS was induced by the MoPn strain Chlamydia
trachomatis (CT), hucMSCs were intravaginally injected in the CS, and we analyzed the infiltrated
macrophage by immunofluorescence.

Results:

We found the markers IL-10 was markedly increased and IL-1β, caspase-1 was notably
downregulated after co-culturing with hucMSCs by RT-PCR. hucMSCs promote macrophage line
RAW264.7 apoptosis. We also found that hucMSCs treatment can alleviate CS by decreasing the
mRNA expression of IL-1β, caspase-1 and MCP-1 in the tubal tissue by RT-PCR and decreasing
the protein expression of IL-1β, caspase-1 and TGF-β by western blotting.

Conclusion:

These results suggest that macrophage function may be related to the immune-modulating
characteristics of hucMSCs that contribute to CS.
Novel Approaches in Materials and Technologies for Building Construction
Authors: Kamal M.A.
Published: January 2024

The book discusses the latest developments in the area of building constructions. Most of the building components such as columns, roofs and concrete blocks are available in prefabricated forms that increase the speed of construction processes. The goal is to engineer buildings that are sustainable, efficient, resilient, economically viable; and ensure the safety, health and comfort of occupants. New materials and technologies aim at energy efficiency, water conservation, improved indoor air quality, durability and low life cycle and maintenance costs.
Thermoelastic Fracture Mechanics
Authors: Petrova Vera , Schmauder Siegfried
Published: January 2024

The book deals with the thermal and mechanical fracture of functionally graded materials on homogeneous substrate (FGM/H) structures. Emphasis is placed on multiple crack interactions. FGMs have a wide range of engineering applications; especially in thermal barrier coatings. Potentially desirable thermal and mechanical properties of functionally graded coatings (FGCs) are analyzed as well as available real material combinations, e.g. (ceramic/metal)/metal.
An Open Label Single Arm Clinical Study on Dashamooladi Yamaka Pratimarsha Nasya and Ashtavargam Kashaya in Vishwachi (Cervical Radiculopathy)
Authors: Chaithra M  , Lakshmiprasad L Jadhav  , Bhagia Gayatri Gangaram
Published: January 2024

Background: Vishwachi is one among the 80 Vatavyadhi. Lakshana of Vishwachi are Bahu Cheshtapaharana, Bahu Karma Kshaya, Stambha, Ruja, Toda, Spandana, Tandra, Gourava and Arochaka. Cervical radiculopathy is a condition similar to Vishwachi,  which  results from compression of cervical nerve roots. This leads to neck pain radiating along the distribution of the affected nerve root, numbness, altered reflexes and weakness in the muscles of arm. Objectives: To evaluate the combined effectiveness of Dashamooladi Yamaka Pratimarsha Nasya and Ashtavargam Kashaya in Vishwachi (Cervical Radiculopathy). Materials and methods: 30 subjects fulfilling the inclusion criteria were administered with Dashamooladi Yamaka Pratimarsha Nasya in the dose of 2 Bindu twice daily after food and Ashtavargam Kashaya, 15ml thrice daily after food, for 14 days. Ruja, Toda, Spandana, Sthambha, Tandra, Gourava, Arochaka, Bahukarmakshya, Bahucheshtapaharana and Spurling test were assessed on 1 st day, 7th day and 15th day. Data were analyzed using appropriate statistical tests. Results and conclusion: Statistically significant (P < 0.05) improvement was observed in symptoms such as Bahu Karmakshaya, Bahu Cheshtapaharana, Ruja, Toda, Spandana and range of cervical movement. Dashamooladi Yamaka Pratimarsha Nasya and Ashtavargam Kashaya were found to be effective in the management of Vishwachi.
An Ayurvedic approach in Monkey Pox - A Review
Authors: Shrikrishna Prakash Gawankar  , Mrudula V. Joshi  , Shivanand P. Divekar
Published: January 2024

Monkey pox is a zoonotic sickness brought about by the monkey pox infection, an orthopoxvirus in the poxviradae family. With its rising dreariness and low casualty rate, it has become endemic all through Focal and West Africa. It signifies a fever, extreme cerebral pain, body ache, enlarged lymph hubs, and a skin rash or sores. Side effects can wait for quite a long time, slowly debilitating the invulnerable framework and ultimately influencing patients with skin diseases, pneumonia, confusion, and eye contaminations that can prompt visual impairment. Ayurveda is an old study of medication in light areas of strength for of firm rules that have shown its preventive and healing viability for the vast majority Anukta Vyadhi's kin enduring today. Ayurvedic analytic and treatment highlights of such Anukta messes have previously been analyzed as far as Dosha pervasiveness. Thus, a coordinated methodology is expected for the fix of monkey pox to further develop the patient's personal satisfaction. In Ayurveda, such popular diseases are delegated Sankramaka Roga, and their side effects are related with Ayurvedic sicknesses, for example, Sannipatika Jwara, Samshoshi Jwara, Masurika, and Brihat Masurika. The objective of this audit is to find an Ayurvedic technique to diagnosing and treating monkey pox ailment. Alongside this preventive methodology utilizing Ayurveda, which is fundamental to stay solid under such pandemic as well as endemic circumstances, is talked about.
Ayurvedic concept of Manas (mind) in perception of knowledge
Authors: Himanshu Sahu  , Vinay Bhardwaj  , C. A. Ghatge
Published: January 2024

Maintenance of health is given prime importance in 'Ayurveda', for that both physical and mental factors are equally important, because the mind act in conformity with the body and the body acts in conformity with the mind. mind is not visible. Any kind of perception and functioning of sensory or motor organs is indicative of presence of mind. Without mind executing as a mediator between external as well as internal environment, soul does not acquire any perception. Ayurveda science strongly proposes mind as chief convener of all external and internal stimuli to body and a mediator for motor reactions to all these stimuli. If Mana is not doing it's duty, nothing is perceived. mind has two properties, namely Anutva and Ekatva. Mind is the seat of pleasure (Sukha) and misery (Duhkha). Understanding the concept of mind is important because balanced state of mind is the ultimate source of health. mind, soul and body are the tripod on which life depends. Both body and mind are the resort of pleasure and disorders.
Conceptual study of Anukta Vyadhi & importance of Ayurvedic Compendia in present era for the treatment of Anukta Vyadhi
Authors: Santoshkumar B. Utlaskar  , GKS Dutta Sharma  , Channabasavva D. Totad
Published: January 2024

Ayurveda is well-established science that deals with every aspect of Human life i.e., how to cure disease and maintain health. Anukta means unstated/unsaid/hidden. Anukta Vyadhi means the disease which is not explained in the Ayurvedic text. In the present era, due to drastic change in climate environment and standard of living, many newer diseases arise which is not mentioned in Samhita. To solve this problem, Acharya has stated that Anukta Vyadhi should be treated as per Hetu and vitiated Dosha and their Sthana. Concept of Anukta helps not only in understanding the classical concept but also set a base for understanding new diseases with a diagnostic approach.