bluuebunny/crossref_metadata_2025 huggingface dataset:
The Development of Scoliosis Following Pinealectomy in Young Chickens is not the Result of an Artifact of the Surgical Procedure
Authors: Bagnall K.  , Raso J.  , Moreau M.  , Mahood J.  , Wang X.  , Beuerlein M.
Published: February 2025

Pinealectomy in young chickens consistently results in scoliosis which has many characteristics similar to those seen in adolescent idiopathic scoliosis. The mechanism underlying this phenomenon remains a mystery and it is not yet entirely clear whether some unidentified aspect of the extensive surgery is the major factor rather than the removal of the pineal gland. Four different types of pinealectomy surgery were performed on young chickens as well as deliberate damage to the cerebral cortex which simulated the extreme of any accidental damage that might occur during surgery. Scoliosis was assessed from weekly radiographs. No differences in incidence of scoliosis, degree of severity or pattern of curve development were observed for any of the experimental groups when compared with controls. In all groups approximately 55% of the chickens developed scoliosis that progressed rapidly. Different pinealectomy procedures and deliberate damage to the cerebral cortex produce scoliosis in young chickens with the same incidence and characteristics. This suggests strongly that the mechanism behind the phenomenon is due to the removal of the pineal gland and not some artifact of the extensive surgery. The pinealectomy model in young chickens is proving to be a good model for studying AIS in humans. An understanding of the mechanism underlying this phenomenon has the potential to provide further insights into the aetiology of AIS and can lead to the development of novel treatement methods.
The Role of Disc, Facets and Fibres in Degenerative Process: a Sensitivity Study
Authors: Dupont P.  , Lavaste F.  , Skalli W.
Published: February 2025

In order to have a better knowledge on the behaviour of the lumbar spine, we investigated the response under loads (flexion, extension, lateral bending and torsion) of a finite element model (L3-L5 segment) submitted to changes of parameters (disc height, nucleus Poisson coefficient, posterior disc fibres, facet orientation and asymmetry and gap). These changes were selected using a Taguchi planning method and the results obtained show that some parameters (disc height, gap, facet orientation) take a high part on motion and stresses while others have a slight influence. It also appears that some interactions between parameters play a significant role.
Biomechanical Modelling of Spinal Growth Modulation for the Study of Adolescent Scoliotic Deformities: A Feasibility Study
Authors: Villemure I.  , Aubin C.-É.  , Dansereau J.  , Labelle H.
Published: February 2025

A model of growth modulation was formulated with variables integrating a biomechanical stimulus of growth modulation, a sensitivity factor to the stimulus and time. It was integrated into a finite element model of the thoracic and lumbar spine using an iterative procedure. A simulation on the personalized geometry of a mild scoliotic patient allowed qualitative investigation of scoliotic deformities over 12 cycles (months) in response to a load variation due to an eccentricity of the patient's gravity line in the frontal plane. Resulting frontal, sagittal and transverse spinal views correspond to clinically observable scoliotic configurations. The simulation adequately reproduces a progressing thoracic scoliotic curve while the slight increasing kyphosis represents a possible condition although a thoracic hypokyphosis is frequently reported in the literature. At the thoracic apex, increased wedging as well as axial rotation evolving towards curve convexity are in agreement with clinical and experimental observations reported with curve progression. This study demonstrates the feasibility of the approach and, compared to other biomechanical models, it achieves a more complete representation of the scoliotic spine by incorporating vertebral growth modulation.
Feasibility Study of Patient-Specific Surgical Templates for the Fixation of Pedicle Screws
Authors: Salako F  , Aubin C-É.  , Fortin C.  , Labelle H
Published: February 2025

Surgery for scoliosis, as well as other posterior spinal surgeries, frequently uses pedicle screws to fix an instrumentation on the spine. Misplacement of a screw can lead to intra- and post-operative complications. The objective of this study is to design patient-specific surgical templates to guide the drilling operation. From the CT-scan of a vertebra, the optimal drilling direction and limit angles are computed from an inverse projection of the pedicle limits. The first template design uses a surface-to-surface registration method and was constructed in a CAD system by subtracting the vertebra from a rectangular prism and a cylinder with the optimal orientation. This template and the vertebra were built using rapid prototyping. The second design uses a point-to-surface registration method and has 6 adjustable screws to adjust the orientation and length of the drilling support device. A mechanism was designed to hold it in place on the spinal process. A virtual prototype was build with CATIA software. During the operation, the surgeon places either template on patient’s vertebra until a perfect match is obtained before drilling. The second design seems better than the first one because it can be reused on different vertebra and is less sensible to registration errors. The next step is to build the second design and make experimental and simulations tests to evaluate the benefits of this template during a scoliosis operation.
A General Algorithm for Magnetic Resonance Imaging Simulation: a Versatile Tool to Collect Information about Imaging Artefacts and New Acquisition Techniques
Authors: Placidi Giuseppe  , Alecci Marcello  , Sotgiu Antonello
Published: February 2025

An innovative algorithm for Magnetic Resonance Imaging (MRI) capable of demonstrating the source of various artefacts and driving the hardware and software acquisition process is presented. The algorithm is based on the application of the Bloch equations to the magnetization vector of each point of the simulated object, as requested by the instructions of the MRI pulse sequence. The collected raw data are then used to reconstruct the image of the object. The general structure of the algorithm makes it possible to simulate a great range of imaging situations in order to explain the nature of unwanted artefacts and to study new acquisition techniques. The way the algorithm structures the sequence has also allowed the easy implementation of MRI data acquisition on a commercial general-purpose DSP-based data acquisition board, thus facilitating the comparison between simulated and experimental results.
How to find out burning problem of telemedicine?
Authors: Kern Josipa  , Becue Monica  , Hercigonja-Szekeres Mira  , Vuletic Silvije
Published: February 2025

Sample of 177 cited papers from Current Contents in year 2001 containing word ‘telemedicine’ as a keyword, and/or in title and/or in abstract. Most of papers were coming from Journal of Telemedicine & Telecare, International Journal of Medical Informatics and Telemedicine Journal & E-Health. Titles and abstracts were analysed statistically by using Sphinx Lexica as a tool and lexical statistics and lexical analysis as methods. Environment/neighbourhood of words potentially reflecting evaluation in telemedicine, enabled to make synthesis: evaluation or similar words were mentioned in connections with programs and plans of telemedicine application in the whole, with economic issue (minimizing, low-cost, reducing cost), with ICT evaluation, quality, and scarcely with methodology and criteria for evaluation.
Indexing of Internet Resources in order to improve the Provision of Problem-relevant Medical Information
Authors: Hoelzer Simon  , Schweiger Ralf Kurt  , Boettcher Hanno  , Rieger Joerg  , Dudeck Joachim
Published: February 2025

Due to the information overload and the unstructured access to (medical) information of the internet, it isn’t hardly possible to find problem-relevant medical information in an appropriate time (e.g. during a consultation). The web offers a mixture of web pages, forums, newsgroups and databases. The search for problem-relevant information for a certain knowledge area encounters on two basic problems. On the one hand, you have to find in the jungle of the information, relevant resources for your individual clinical case (treatment, diagnosis, therapeutic option etc..). The second problem consists of being able to judge the quality of individual contents of internet pages. On the basis of the different informational needs of health care professionals and patients a catalog with internet resources was created to tumor diseases such as lung cancer (small cell and non-small cell carcinoma), colorectal cancer and thyroid cancer. Explicit and implicit metainformation, if available, such as the title of the document, language, date or keywords are stored in the database. The database entries are editorially revised, so that further specific metainformation is available for the information retrieval. Our pragmatic approach of searching, editing, and archiving of internet content is still necessary since most of the web documents are based on HTML, which doesn’t allow for structuring (medical) information and assigning metainformation sufficiently. The use of specific metainformation is crucial in order to improve the recall and precision of internet searches. In the future, XML and related technologies (RDF) will meet these requirements.
Healthcare Teams Over the Internet: Towards a Certificate-based Approach
Authors: Christos GEORGIADIS K.  , Ioannis MAVRIDIS K.  , George PANGALOS I.
Published: February 2025

Healthcare environments are a representative case of collaborative environments since individuals (e.g. doctors) in many cases collaborate in order to provide care to patients in a more proficient way. At the same time modern healthcare institutions are increasingly interested in sharing access of their information resources in the networked environment. Healthcare applications over the Internet offer an attractive communication infrastructure at worldwide level but with a noticeably great factor of risk. Security has therefore become a major concern for healthcare applications over the Internet. However, although an adequate level of security can be relied upon digital certificates, if an appropriate security policy is used, additional security considerations are needed in order to deal efficiently with the above team-work concerns. The already known Hybrid Access Control security model supports and handles efficiently healthcare teams with active security capabilities and is capable to exploit the benefits of certificate technology. In this paper we present the way for encoding the appropriate authoritative information in various types of certificates, as well as the overall operational architecture of the implemented access control system for healthcare collaborative environments over the Internet. A pilot implementation of the proposed methodology in a major Greek hospital has shown the applicability of the proposals and the flexibility of the access control provided.
Development of Electronic Form of the 1999 WHO/ISH Hypertension Guidelines
Authors: Peleska Jan  , Zvara Karel  , Vesely Arnost  , Zvarova Jana  , Tomeckova Marie  , Hanzlicek Petr
Published: February 2025

An electronic form of 1999 ISH/WHO Guidelines for Management of Hypertension was developed. It concentrates on two main problems - assessment of a patient's cardiovascular risk and selecting drug treatment. Moreover, it can remind the risk of unfilled items both for a cardiovascular risk calculation and drug contraindications. It can be stored for comparison with other records from follow-up both in an electronic and paper form.
The Cadmio XML Healthcare Record
Authors: Barbera Francesco  , Ferri Fernando  , Ricci Fabrizio L.  , Sottile Pier Angelo
Published: February 2025

The management of clinical data is a complex task. Patient related information reported in patient folders is a set of heterogeneous and structured data accessed by different users having different goals (in local or geographical networks). XML language provides a mechanism for describing, manipulating, and visualising structured data in web-based applications. XML ensures that the structured data is managed in a uniform and transparent manner independently from the applications and their providers guaranteeing some interoperability.
Supporting Clinical Practice Guidelines: Lifecycle of Guidelines for Oncology within an XML-based Guideline Framework
Authors: Mludek Volker  , Wolff Astrid Corinna  , van der Haak Minne  , Schweiger Ralf  , Hölzer Simon  , Dudeck Joachim  , Wetter Thomas
Published: February 2025

Clinical Practice Guidelines (CPGs) have become important instruments for supporting patient care. Many structure models for CPGs have been developed to explicitly gain structured CPG documents, some of them using XML. Often, however, problems arise in filling these structures with content and integrating CPG applications into an EPR/HIS The Universities of Giefien and Heidelberg have each presented an XML-based CPG structure, which are actually being merged into one. The obtained CPG structure will build our common “xCPG core model” embedded in an “XML framework”, an authoring environment. This paper shows how this model used in the framework could support the entire 5-step CPG lifecycle, spanning CPG development, the integration of a CPG into an EPR/HIS, as well as maintenance. Furthermore, this paper points out how the method draws on the different information management services as a precondition for successful CPG implementation.
Evaluation during design of a regional seamless network of social and health care services - information technology perspective
Authors: Nykänen Pirkko  , Karimaa Erkki
Published: February 2025

This paper reports results from a constructive evaluation study where design of a reagional social and health care information system was assessed from information technology perspective. We studied the models of social and health care processes, the needs and requirements of the clients and users and the planned information system. Our results envision the importance to focus during the design on the service chain and process models, including strategic processes where the mission, vision and values of the organisation are represented. Also, the stakeholders' needs and requirements for the system need to be explicitly described and included as system functionalities and characteristics. Additionally, theoretical frameworks from health informatics are needed to understand the phenomenon under study, to build a model and to develop implementations and installations of the model in the social and health care organisational context
On Prediction of Hearing Recovery After Acute Acoustic Trauma Caused by Impulse Noise
Authors: Iltanen Olli  , Juhola Martti  , Savolainen Seppo  , Ylikoski Jukka
Published: February 2025

The present study investigates the prediction of how successfully hearing returns to normal after an acute acoustic trauma caused by a firearm shot, an explosion or other impulse noise. Study material consisted of 113 conscripts who had suffered an acute acoustic trauma during their military service. A logistic regression model was formed to predict hearing recovery. From several possible variables at least five were found to be important among our dataset, which is still rather limited. However, more data will be acquired later in order to elaborate the research more widely by using other methods also.
Implementing Regional Information System For Social and Health Care in Finland, Satakunta
Authors: Mikola Tuire  , Wanne Olli  , Itälä Timo  , Virtanen Aino
Published: February 2025

The Regional Information System, RIS is based on the open, regional architecture and it supports the regional, client-oriented seamless services in social and health care. By using the RIS it is possible for professionals for example to get an overview of the client’s situation and to make a service chain plan for the client with the client's consent. The client can get access to his/her own data and to see his/her service plan, consents and log file. The development of the RIS started in the area of Satakunta in January 1999 and the implementation started in November 2001 in a national Macro Pilot project. The Ministry of Social Affairs and Health prepared a special law for Satakunta to enable the handling of client data in a regional context and the developing a regional system. The Ministry selected in the Spring 2001 three regions more in Finland to develop their services within the experimental Act. These four regions are approximately 50 % out of the population in Finland.
Co-operative Bidding of SMEs in Health Care Sector
Authors: Mezgár István  , Kovács György  , Bonfatti Fabio
Published: February 2025

Tendering become an important process for customers in the health care sector to select products and services from the market for the lowest price, with the highest quality and with the shortest delivery time. The number of SMEs (Small and Medium-sized Enterprises) delivering products or services for the health care sector is increasing, but they have usually limited capital and expertise to participate in tenders. The paper introduces a possible solution for this problem, when SMEs form special groups, so called Smart Bidding Organisations (SBO), to prepare a bid for the tender jointly. The SBO appears for the customer (tender issuer) as a single enterprise and the bidding procedure will be faster and less expensive in this way.
The Effects of Mechanical Loading on the mRNA Expression of Growth-Plate Cells
Authors: Villemure I.  , Chung M.A.  , Seck CS.  , Kimm M.H.  , Matyas J.R.  , Duncan N.A.
Published: February 2025

Bone growth is a complex process involving proliferation, maturation and hypertrophy of chondrocytes in the growth plates. Mechanical forces applied to growing bones alter their longitudinal growth. However, the mechanisms by which chondrocytes modulate longitudinal bone growth are not well understood. This in vitro study investigated the effects of mechanical loading on the mRNA expression pattern of key molecular components of the growth-plate. Short-term static loading was applied to rat proximal tibial growth-plate explants. Various age groups at specific developmental stages were investigated. In situ hybridization was used to assess the mRNA expression of the cells in different zones of the growth-plate. Four key components were investigated: 18s (basic cell metabolism), type II collagen (major extracellular matrix component), type X collagen (matrix component in hypertrophic zone) and PTH-PTHrP receptors (pre-hypertrophic chondrocytes). The spatial variation in the mRNA expression between loaded explants and their contralateral controls was compared to establish: - the sensitivity of the different growth-plate zones to mechanical loading; - the sensitivity of the different developmental stages to loading. Preliminary results indicated that static loading on the growth plate of 80 d.o. rats affects type II and X collagen gene expressions while PTH-PTHrP remains insensitive to static loading. Improved understanding of growth- plate mechanics and the underlying biology is required to provide a scientific basis for the treatment of progressive deformities.
Baropodographic Measurements and Averaging in Locomotion and Postural Analysis
Authors: D'Amico Moreno  , Roncoletta Piero
Published: February 2025

The use of quantitative baropodography measurements, either by means of pressure sensing foot insoles or floor mats, is quickly increasing in clinical and research fields for the analysis of a wide variety of foot and ankle disorders. In this paper we present a set of complex and detailed processing procedures necessary to correctly perform gait cycles normalisation and averaging as well as bivariate statistic for COP analysis, in order to extract quantitative and statistically significant parameters for clinical evaluation of locomotion and orthostatic posture.
Movement analysis of scoliotic subjects using Fastrak
Authors: Rahmatalla Aziz  , Chockalingam Nachiappan  , Dangerfield Peter  , Ahmed El-Nasri  , Cochrane Tom  , Dove John  , Maffulli Nicola
Published: February 2025

An attempt has been made to simplify the measurement of composite movement involving abnormal rotation in scoliosis, which is considered to have an important role in the diagnosis and treatment of the condition. Analysis of three-dimensional movement provides pertinent information concerning the morphological description of scoliotic deformities. The description of this movement is of clinical interest for aiding diagnosis and/or prognosis of spinal deformity evolution. Previous studies have indicated that idiopathic scoliosis is a three-dimensional deformity accompanied by a generalised torsion phenomenon and attempts have been made to associate the geometric torsion index with the curvi-linear shape of idiopathic scoliosis.
3D Detailed Reconstruction of Vertebrae with Low Dose Digital Stereoradiography
Authors: Le Bras A.  , Laporte S.  , Mitton D.  , de Guise J.A.  , Skalli W.
Published: February 2025

As scoliosis requires a global and local 3D examination of the spine in standing position, stereoradiography appears as one of the most adequate 3D imaging tool for it diagnosis. Our purpose was to increase the geometry definition of the stereoradiographic reconstruction to obtain morpho-realistic models and to validate them using 41 dry vertebrae. Our results propose 2000 points 3D personalised models without any loss of accuracy in comparison to previous studies.
Assessment of the validity of observing three-dimensional images of the spine using polarising, synchronised techniques
Authors: Salvador Shannon  , Wang Xiaoping  , Moreau Marc  , Raso James  , Mahood James  , Currah Ryan  , Bagnall Keith
Published: February 2025

Three-dimensional imaging is an emerging technique in radiology. It might be used to help view the spine and assist in improving evaluation of scoliosis. These images are currently computer generated and although very effective are actually optical illusions. Questions remain as to the reliability and validity of these images which are important considerations when treatment regimens are being developed and surgery contemplated. Using a constructed three-diemnsional image of a box, this study assessed the inter- and intra-reliability of viewing a specific point on this box and also the inter-reliability of identifying the coordinates of this same point. There was good reliability for viewing a single point in the X and Z axes which formed the plane of the computer but there was a 10X decrease in reliability along the Y-axis (depth). This pattern was repeated when considering the relationship between observers to identify the actual coordinates of the same point.
Conservative management in patients with scoliosis – does it reduce the incidence of surgery?
Authors: Weiss Hans-Rudolf  , Weiss Grita  , Schaar Hans Jürgen
Published: February 2025

The effectiveness of conservative scoliosis treatment, including bracing, is widely denied. Like any therapeutic intervention, conservative scoliosis treatment including patient education, techniques of brace moulding, and time-consuming follow-ups is reasonable only if the benefits outweigh the strain placed upon the patient by the treatment. The most important benefit of early intervention in scoliosis is prevention of the need for spinal fusion surgery.
Study of vertebral morphology in Scheuermann’s kyphosis before and after treatment
Authors: Pola E.  , Lupparelli S.  , Aulisa A.G.  , Mastantuoni G.  , Mazza O.  , De Santis V.
Published: February 2025

Variation of vertebral morphology in Scheuermann’s Kyphosis before and after orthopedic treatment is usually measured by the entity of the curve, using Cobb’s method, and by vertebral wedging. But the lack of correlation between these parameters and the clinical evolution of the deformity, lead to the possibility of other alterations that can explain part of the kyphosis deformities before and after the treatment. In this group of alterations the inclination of anterior and posterior walls, that express the trapezoid deformity of vertebras, seem to be more reliable indicators of curve response to ortopedic treatment.
Prediction of Curve Progression in Idiopathic Scoliosis from Gene Polymorphic Analysis
Authors: Inoue Masatoshi  , Minami Shohei  , Nakata Yoshinori  , Takaso Masashi  , Otsuka Yoshinori  , Kitahara Hiroshi  , Isobe Keijiro  , Kotani Toshiaki  , Maruta Tetsuro  , Moriya Hideshige
Published: February 2025

Three hundred and four girls with adolescent idiopathic scoliosis were investigated to determine if DNA polymorphisms in the vitamin D receptor (VDR), estrogen receptor (BR), and CYP17 gene were related to curve progression of idiopathic scoliosis. The results suggested that XbaJ site polymorphism in the ER gene was associated with curve progression. The Cobb's curve angle with genotype XX and Xx was statistically greater than that with genotype xx. The curve progression risk (∼5 degrees) was higher for genotype XX and Xx than for genotype xx. Furthermore, patients with genotype XX and Xx had a higher risk of receiving operative treatment than those with genotype xx. In conclusion, DNA analysis may predict curve progression, although other polymorphisms were not associated with curve severity.
An Integrated Drug Prescription and Distribution System: Challenges and Opportunities
Authors: Lanssiers R.  , Everaert E.  , De Win M.  , Van De Velde R.  , De Clercq H.
Published: February 2025

Using the hospital’s drug prescription and distribution system as a guide, benefits and drawbacks of a medical activity management system that is tightly integrated with the supply chain management of a hospital will be discussed from the point of view of various participating healthcare actors.
ICT in Nursing in Dutch Hospitals
Authors: Hilderink (NICTIZ) H.G.M.  , Epping (Epping consultancy) P.EPPING  , Goossen (Acquest) W.T.F.
Published: February 2025

VIZI and its successor NICTIZ (National ICT Institute for Healthcare) carried out a study to assess the status of ICT use in hospitals. The statutory obligation for the retention of care records and instructions was highlighted by the professional nursing institutions. Literature was studied to find out more about the contribution of nursing records to the care provided. Nursing records are kept in all hospitals, and keeping a good record is essential to the care. Nevertheless not much evidence was found to support the idea that the traditional way of keeping of keeping a nursing record has substantial positive effect on the care provided. It became clear however that Clinical Pathways does indeed seem to be promising as a protocol for treating patients and putting demands on registration, and to provide a clear method by which the electronic nursing record could be built up as a part of the integrated electronic patient record. By means of two questionnaires, one applied to suppliers and one applied to hospitals, the status of ICT in hospitals was addressed. It transpired that several suppliers are active in this area, but usually with general EPR Systems which have little dedicated functionality for nurses. The number of nurses in hospitals who are using computers on a regular basis is on the increase. It also transpired that most of the functions that are being used by nurses are general functions such as recording demographie patient data, roster planning, etc. Finally we asked the hospitals to send us information about their own projects. Some 20 projects where submitted, 10 of which were regarded as being significant. The best application was rewarded with a prize.
Inclusion of 3-D Computed Tomography Rendering and Immersive VR in a Third Year Medical Student Surgery Curriculum
Authors: Mastrangelo Jr Michael J  , Adrales Gina  , McKinlay Rod  , George Ivan  , Witzke Wayne  , Plymale Margaret  , Witzke Don  , Donnelly Mike  , Stich Jeremy  , Nichols Mathew  , Park Adrian E
Published: February 2025

Computed tomography (CT) scans are frequently used for preoperative evaluation of patients undergoing complex surgery and are therefore commonly encountered by medical students on their surgical rotations. Interpretation of these CT scan images is therefore an integral component of all medical students' surgical rotations. Additionally, advanced rendering available from modem scanners and registration of multimodal or serial scans require the student to understand how volumetric anatomy relates to cross-sectional anatomy. The utility of three-dimensional (3-D) models for conveying surgical anatomy has been demonstrated. (1) Immersive 3-D VR overcomes many of the conceptual limitations encountered when conveying or teaching 3-D relationships via 2-D images traditionally produced by these scans. We are currently using augmented reality as a teaching tool and have incorporated 3-D immersive environments in the third year medical student Surgery rotation. Initial results suggest that this is an effective tool for teaching third year medical students. 3-D CT rendering and immersive VR provide an effective process for utilizing CT datasets to teach surgical anatomy to medical students.
Analyzing the MMVR Research Space: Past Emphases, Future Directions
Authors: Combs C. Donald
Published: February 2025

The MMVR Conference is one of a handful of national forums where leading researchers regularly convene to discuss medical modeling and simulation. As such, the presentations made during the conference represent a reasonable overview of both the state-of-the-art in virtual reality in medicine and the basic and applied research trends in the field. This article describes those trends and some of the implications based on a meta-analysis of almost three hundred articles published as a result of the MMVR Conferences in 2000, 2001, and 2002.
Virtual Reality and Interactive 3D as Effective Tools for Medical Training
Authors: Webb George  , Norcliffe Alex  , Cannings Peter  , Sharkey Paul  , Roberts DAVE
Published: February 2025

CAVE-like displays allow a user to walk in to a virtual environment, and use natural movement to change the viewpoint of virtual objects which they can manipulate with a hand held device. This maps well to many surgical procedures offering strong potential for training and planning. These devices may be networked together allowing geographically remote users to share the interactive experience. This maps to the strong need for distance training and planning of surgeons. Our paper shows how the properties of a CAVE-Like facility can be maximised in order to provide an ideal environment for medical training. The implementation of a large 3D-eye is described. The resulting application is that of an eye that can be manipulated and examined by trainee medics under the guidance of a medical expert. The progression and effects of different ailments can be illustrated and corrective procedures, demonstrated.
A Mobile and Navigated Image Viewer for Surgery - Evaluation of Precision
Authors: Weber Stefan  , Hein Andreas  , Lueth Tim C.
Published: February 2025

We report work on a newly developed and ultra compact mobile viewing device, called NaviView to display medical imaging data (i.e. from a computer tomograph - CT) in situ. The system comprises an optical tracking system to detect both the patients and the viewing devices position and display a proportionable part of the medical image data on a mobile viewing device. This article describes experiments carried out to evaluate the overlay precision of two different imaging modalities (i.e. live video and CT) being visualized.
3D Tooth Shape from Radiographs using Thin-Plate Splines
Authors: Enciso Reyes  , Lewis John P.  , Neumann Ulrich  , Mah James
Published: February 2025

Current methods to produce 3-dimensional tooth root models involve conversion from radiographic means (computed tomography) or creation using computer-assisted design (CAD) software. The former lacks detail while the second is manually fabricated and can bear little resemblance to the original. Thin-plate splines have been used in morphometries to define changes of shape between subjects of the same species [1]. Herein, we use thin-plate splines to deform a 3D geometric prior model of a tooth to match 2D patient radiographs, producing a "best- fit" patient specific 3D geometric polygonal mesh of the tooth.
Law and standards faced to market rules in health information security
Authors: Allaert F.A.  , Le Teuff G.  , Quantin C.
Published: February 2025

This paper presents the main differences existing in the elaboration process of law and standard and analyses their potential conflicts. It also describes the respective force of law and standards in three main areas : legal threat versus financial threat, conflict versus cooperation and finally their respective position faced to oligarchic power.
Robot-based Tele-Echography: the TER system
Authors: Vilchis Adriana  , Masuda Kohji  , Troccaz Jocelyne  , Cinquin Philippe
Published: February 2025

This paper presents a master-slave robotized system enabling a remote echographic diagnosis. The expert holds a virtual probe placed on a haptic device; he moves this virtual probe in order to control the motion of the real probe positioned on the body of the patient located remotely. The real probe is placed on a lightweight and user-friendly slave robot and moved by it. The contact force between the probe and the patient is fed back to the operator allowing him to have a haptic virtual environment. The aim of this haptic control is to preserve the medical expert proprioception in order to the facilitate hand-eye coordination necessary to echographic examination. In this paper we present the architecture of the system and experimental results.
Numerical investigation of blood flow in the. arterial stenosis
Authors: Bernad Sandor I  , Bernad Elena  , Mihalas George I
Published: February 2025

In the cardiovascular system, altered flow conditions — such as separation, flow reversal, and low or oscillatory shear stress areas — are recognized as important factors in the development of arterial disease. A detailed understanding of the local hemodynamics, of the effects of vascular wall modification on flow patterns, and of longterm adaptation of the system to surgical procedures can have useful clinical applications. In this context, the availability of effective and accurate numerical simulation tools could be a real breakthrough.
Enabling virtual emergency healthcare enterprises using web services
Authors: Poulymenopoulou M.  , Vassilacopoulos G.
Published: February 2025

Emergency healthcare delivery involves a variety of activities performed from the time of a call to the ambulance service till the time of patient’s disposal from the emergency department of a hospital. As these activities are performed in at least two organizations (i.e. ambulance service and hospital) and they are interrelated to form inter-organizational healthcare processes, collaboration and coordination become a vital issue for patients and for emergency healthcare service performance. Webbased workflow systems in conjunction with web services present a new way for service-oriented integration (SOl) of disparate systems and for developing distributed applications within and between organizations. Thus, through process automation and the use of web services ambulance service and hospital emergency departments can automate their operations by making information available where and when needed and by providing an infrastructure for the integration of prehospital and in-hospital emergency healthcare. A prototype implementation of this approach is presented in this paper.
Body Surface Potential Mapping – the application in men from the twenty years lasting epidemiological study
Authors: Tomešková Marie  , Boudík František  , Aschermann Michael  , Zvárová Jana  , Anger Zdeněk  , Stanovská Zuzana
Published: February 2025

Body surface potential mapping (BSPM) enables to obtain more information about local changes of the heart electrical field then classical electrocardiography makes it possible.
The Effect of a General Lexicon in Corpus-Based Identification of French-English Medical Word Translations
Authors: Chiao Yun-Chuang  , Zweigenbaum Pierre
Published: February 2025

We present a method, based on the similarity of word distribution across languages, of finding `new’ words’ translations in French-English comparable medical texts, starting from a partial bilingual medical lexicon. In this paper, we test the influence of adding general-language words to this initial lexicon. Our experimental results show that all test words are correctly translated within the top 25 candidates; and that the addition of general words to the lexicon helps to improve translation accuracy for medical words.
Re-use of a multi-purpose knowledge corpus on cortex anatomy for educational purposes
Authors: Gibaud Bernard  , Dameron Olivier  , Morandi Xavier
Published: February 2025

This work aims at producing a software package to be used during “hands on” sessions about anatomy, focusing on gross brain cortex anatomy. Emphasis is put on the 3D shape and topology of the cortex anatomical structures, described both using numeric data (derived from MRI images) and symbolic data (“part-whole”, topological realtions). “Spatial” and “semantic” synchronisation are provided to connect the numeric and symbolic knowledge. The knowledge corpus includes both 3D data showing the sulci, the gyri and the 3D MRI data, and a general purpose symbolic knowledge base of brain cortex anatomical features. Implementation is achieved using web technologies.
Healthcare networks services for patients and large public : methodological and engineering issues
Authors: Salzano Gabriella  , Bourret Christian
Published: February 2025

In this paper, we analyse the services supplied by innovative and transversal healthcare organisations to satisfy patients and large public requirements and we illustrate them with the French healthcare networks. We classes these services in two groups, healthcare delivery services and health related information services, and we define three layers for their possible contexts. We will use an Information System perspective to investigate about various methodological approaches to realise each group of services and we compare their challenges and difficulties. Finally, we identify methodological and engineering issues common to both groups.
The Effect of Sample Size and MLP Architecture on Bayesian Learning for Cancer Prognosis — A case study
Authors: Anh Trinh Quôc  , Hoàng Thu  , Dorizzi Bernadette  , Asselain Bernard
Published: February 2025

In this paper we investigate the independent effects of training sample size and multilayer perceptron (MLP) architecture on Bayesian learning to build prognostic models for metastatic breast cancer. We trained two types of Bayesian neural networks on a data set of 1477 metastatic breast cancer patients followed at the Institut Curie using disjoint training sets of sizes k=50, 100, 200, 300, and 450. The learning performance as measured by an expected loss appeared independent of the two architectures modelling the log hazard function under either proportional or non proportional hazard assumptions, thus indicating that no other sources of nonlinearity besides interactions are present. We found a performance breakdown at k=50, and no sample size effect for k≥100.
Evaluation of user acceptance of information systems in health care — the value of questionnaires
Authors: Ammenwerth Elske  , Kaiser Frieda  , Wilhelmy Immanuel  , Höfer Stefan
Published: February 2025

The use of modern information technology (IT) offers tremendous opportunities such as reducing clinical errors and supporting health care professionals in providing care. Evaluation of user satisfaction is often seen as a surrogate for the success of an information systems.
Structure Data Entry using Graphical Input: Recording Symptoms for Multiple Sclerosis
Authors: McCullagh P J  , McGuigan J  , Fegan M  , Lowe-Strong A
Published: February 2025

Structured Data Entry provides flexible and efficient input to the computer-based patient record We have utilized the SDE approach to build a prototype interface for recording common symptoms associated with Multiple Sclerosis (MS). The software provides both graphical input and output, to facilitate efficient data entry and monitoring of data. Graphical input is transformed to textual information, which is stored in a database in a hierarchical tree structure. Pain management in MS may be achieved by careful monitoring of the symptom in response to treatment. Pain location is selected on a body image and severity and other attributes represented using a graphical visual analog scale, leading to more convenient input and a less ambiguous coding than is achievable with narrative text alone. This approach could provide an objective means of monitoring the progress of the disease and management of the symptoms. The intuitive interface may also facilitate self-monitoring.
A Platform to Develop and to Improve Effectiveness of Online Computable Guidelines
Authors: Dufour Jean-Charles  , Fieschi Marius  , Fieschi Dominique  , Giorgi Roch  , Gouvernet Joanny
Published: February 2025

The quality criteria of guidelines are identified Taking these criteria into account we have built a platform to improve computable guideline effectiveness and facilitate their production. Our implementation is based on the GLIF Model (GuideLine Interchange Format). We have designed software components to edit, test, index, perform and present guidelines in a user-friendly Web architecture. These components are based on XML specifications in order to preserve their shareability and their re-usability. Several guidelines have been developed using our approach. We discuss the advantages of such an implementation and future evolutions so as to improve guideline integration within the clinician’s workflow.
Improving the quality of communication in healthcare
Authors: Toussaint P.J.  , Verhoef J.  , Vliet Vlieland T.P.M.  , Zwetsloot-Schonk J.H.M.
Published: February 2025

In this paper we present an assessment instrument for evaluating the quality of communication processes in health care. This instrument is based on communication theory, and does not only indicate the level of quality, but also explains it. This makes it also useful as a design tool in reorganising communication processes, in order to make them more effective. Such a tool is highly needed when Information and Communication Technology is applied in health care to support communication between professionals. The instrument is demonstrated for a case in multidisciplinary team care.
The Evolution of Health Information Systems, Security in Practice and Open Issues
Authors: Bakker Albert R.
Published: February 2025

Security issues during development and implementation of hospital information systems are briefly reviewed. Attention is paid to current issues as to: availability, integrity, authentication and access rights. In particular are discussed:
Palpation Imaging Using a Haptic System for Virtual Reality Applications in Medicine
Authors: Khaled W.  , Reichling S.  , Bruhns O.T.  , Boese H.  , Baumann M.  , Monkman G.  , Egersdoerfer S.  , Klein D.  , Tunayar A.  , Freimuth H.  , Lorenz A.  , Pessavento A.  , Ermert H.
Published: February 2025

In the field of medical diagnosis, there is a strong need to determine mechanical properties of biological tissue, which are of histological and pathological relevance. Malignant tumors are significantly stiffer than surrounding healthy tissue. One of the established diagnosis procedures is the palpation of body organs and tissue. Palpation is used to measure swelling, detect bone fracture, find and measure pulse, or to locate changes in the pathological state of tissue and organs. Current medical practice routinely uses sophisticated diagnostic tests through magnetic resonance imaging (MRI), computed tomography (CT) and ultrasound (US) imaging. However, they cannot provide direct measure of tissue elasticity. Last year we presented the concept of the first haptic sensor actuator system to visualize and reconstruct mechanical properties of tissue using ultrasonic elastography and a haptic display with electrorheological fluids. We developed a real time strain imaging system for tumor diagnosis. It allows biopsies simultaneously to conventional ultrasound B-Mode and strain imaging investigations. We deduce the relative mechanical properties by using finite element simulations and numerical solution models solving the inverse problem. Various modifications on the haptic sensor actuator system have been investigated. This haptic system has the potential of inducing real time substantial forces, using a compact lightweight mechanism which can be applied to numerous areas including intraoperative navigation, telemedicine, teaching and telecommunication.
A One-DOF Freehand Haptic Device for Robotic Tele-Echography
Authors: Marchal Maud  , Troccaz Jocelyne
Published: February 2025

Tele-echography may be an interesting alternative to conventional care when the medical expert is not close to the patient to be examined. In a system for tele-echography, medical expert proprioception and gesture feelings must be preserved to synchronize the ultrasound images with the motion made by the physician. It is why we develop a master-slave system for robotic tele-echography integrating force feedback. Because existing haptic devices are not fully adapted to this application – their workspace is often small and their basis is fixed –, we have developed a one-dimensional free-hand force feedback device. In this paper, we describe the design and a first evaluation of this new haptic device for robotic teleechography.
An Adaptive Driver and Real-Time Deformation Algorithm for Visualization of High-Density Lung Models
Authors: Santhanam Anand  , Fidopiastis Cali  , Tal Amir  , Hoffman-Ruddy Bari  , Rolland Jannick
Published: February 2025

Technological advances in Augmented Reality (AR) and extraction of 3D patient specific medical data led to the creation of medical visualization using AR environments, in which the 3D data is registered and synchronized with the position of the patient. One of the challenges in such visualization environments is maintaining an accurate shape of the 3D data for self-deformable models such as lungs. An accurate deformation of lung model with 3D visualization may significantly increase the teaching and diagnosing ability of physicians.
Segmentation and Generation of Patient-Specific 3D Models of Anatomy for Surgical Simulation
Authors: Smith Matthew  , Faraci Alessandro  , Bello Fernando
Published: February 2025

Patient-specific simulation requires detailed 3D anatomical models. This paper describes how using optimised MRI sequences and clear segmentation criteria, together with adequate segmentation tools can produce high fidelity models able to reflect anatomical variability and allow realistic simulation of operative techniques and conditions.
Computer-Based Simulator for Catheter Insertion Training
Authors: Aloisio Giovanni  , Barone Luigi  , Bergamasco Massimo  , Avizzano Carlo Alberto  , De Paolis Lucio Tommaso  , Franceschini Marco  , Mongelli Antonio  , Pantile Gianluca  , Provenzano Luciana  , Raspolli Mirko
Published: February 2025

Minimally invasive surgery procedures are getting common in surgical practice; however the new interventional procedure requires different skills compared to the conventional surgical techniques. The need for training process is very important in order to successfully and safely execute a surgical procedure.