bluuebunny/crossref_metadata_2025 huggingface dataset:
Incorporating Interpersonal Psychotherapy for Postpartum Depression Into Social Work Practice in Israel
Authors: Posmontier Bobbie , Bina Rena , Glasser Saralee , Cinamon Tali , Styr Benedict , Sammarco Therese
Published: June 2017

Purpose:

To determine feasibility and acceptability of incorporating IPT for postpartum depression (PPD) into Israeli social work practice.

Method:

Women who were 4–24 weeks postpartum with PPD, at least 18 years old, had telephone access, and had a score of 10–18 on the Edinburgh Postnatal Depression Scale (EPDS) were eligible to participate in this two-group, nonrandomized repeated measures pilot. The intervention group received eight 50-min IPT sessions and the comparison group received treatment-as-usual. Primary outcomes were measured with the EPDS, Postpartum Adjustment Questionnaire (PPAQ), and Client Satisfaction Scale-8.

Results:

There was a significant reduction in both groups in EPDS scores at the end of treatment ( t = −4.68, 95% CI [−6.49, −2.57], d = 1.07) and 4 weeks posttreatment ( t = −5.09, 95% CI [−7.14, −3.08], p < .001, d = 1.21), a significant reduction in PPAQ scores at the end of treatment ( t = −2.09, 95% CI [−0.29, 0.00], p < .05, d = 0.44), and high patient acceptability.

Discussion:

This study provided preliminary evidence supporting IPT use by social workers in Israel.
Impact of Diabetes Care by Pharmacists as Part of Health Care Team in Ambulatory Settings: A Systematic Review and Meta-analysis
Authors: Fazel Maryam T. , Bagalagel Alaa , Lee Jeannie K. , Martin Jennifer R. , Slack Marion K.
Published: June 2017

Objective: To conduct a comprehensive systematic review and meta-analyses examining the impact of pharmacist interventions as part of health care teams on diabetes therapeutic outcomes in ambulatory care settings. Data Sources: PubMed/MEDLINE, EMBASE, Cochrane Library, International Pharmaceutical Abstracts, Web of Science, Scopus, WHO’s Global Health Library, ClinicalTrials.gov , and Google Scholar were searched (1995 to February 2017). Search terms included pharmacist, team, and diabetes. Study Selection: Full-text articles published in English with comparative designs, including randomized controlled trials, nonrandomized controlled trials, and pretest-posttest studies evaluating hemoglobin A1C(A1C), were assessed. Data Extraction and Synthesis: Two reviewers independently screened for study inclusion and extracted data. Quality of the studies was assessed using tools developed based on the framework of the Cochrane Collaboration’s recommendations. Data Synthesis: A total of 1908 studies were identified from the literature and reference searches; 42 studies were included in the systematic review (n = 10 860) and 35 in the meta-analyses (n = 7417). Mean age ranged from 42 to 73 years, and 8% to 100% were male. The overall standardized mean difference (SMD) for A1C for pharmacist care versus comparison was 0.57 ( P < 0.01), a moderate effect representing a mean difference of 1.1% (95% CI = 0.88-1.27). The effects for systolic blood pressure and low-density lipoprotein cholesterol were between small and moderate (SMD = 0.31 and 0.32; P < 0.01). The heterogeneity was high for all outcomes (>83%), indicating functional differences among the studies. No publication bias was detected. Conclusion: Pharmacists’ interventions as part of the patient’s health care team improved diabetes therapeutic outcomes, substantiating the important role of pharmacists in team-based diabetes management.
Obiltoxaximab: Adding to the Treatment Arsenal for Bacillus anthracis Infection
Authors: Hou Audrey W. , Morrill Amanda M.
Published: June 2017

Objective: To review the safety and efficacy of obiltoxaximab, a monoclonal antibody indicated for the treatment of Bacillus anthracis inhalational anthrax in adult and pediatric patients. Data Sources: A MEDLINE (1946 to May, week 1, 2017) and EMBASE (1980 to 2017, week 19) search was performed using the search terms obiltoxaximab OR ETI-204 OR Anthim AND anthrax. Study Selection and Data Extraction: All English-language clinical studies in both animal and human models assessing the safety and efficacy of obiltoxaximab were included. Data Synthesis: A total of 5 articles have been published on clinical studies examining safety and efficacy of obiltoxaximab. Efficacy studies in 2 animal models, New Zealand White rabbits and cynomolgus macaques, showed higher rates of survival post–anthrax exposure when obiltoxaximab was administered. Safety studies in healthy human volunteers showed that it was tolerated, with a relatively low incidence of adverse events. Conclusion: Based on these clinical studies and the implausibility of conducting a trial in infected individuals, obiltoxaximab is a safe and efficacious addition to the anthrax antitoxin armamentarium to protect against and treat inhalational anthrax.
‘A touch of power’: Agents, dynamics and multiple perspectives in running a research project
Authors: Mæland Kjellfrid
Published: June 2017

The aim of this study is to get an insight into how members of a research project group describe and interpret the dynamic relations in the group in running a research project investigating improvisation in teacher education. The empirical data consists of field notes from the research group meetings and project events in the initial phase of the project, and from retrospective interviews with the research project group a year later. The data was analysed in an abductive process in light of the concept of power and the concept of the group as an interpretative zone. The findings indicate that there is ‘a touch of power’ when reflecting on followership and leadership, conflicts and professional disagreement, and unity and multiple perspectives.
The rise of a neo-communitarian project: A critical youth work study into the pedagogy of the National Citizen Service in England
Authors: Murphy Seán F
Published: June 2017

This article draws upon recent empirical data from a series of in-depth qualitative interviews conducted with professional youth work practitioners. It is focused upon contemporary practice experiences of social action and youth citizenship projects across North East England. The research provides a more nuanced understanding of the National Citizen Service programmes to make sense of the meaning of citizenship in the twenty-first century. The findings contribute towards a critical appraisal of the National Citizen Service as a vehicle for youth social action in the changing social, economic and political landscapes in a post-Brexit society. It offers some useful insights into approaches to practice interventions, the impact on young people and contests the type of citizen envisaged within the NCS curricula and pedagogy. It adopts a critical perspective to explore recent government rhetoric and seeks to identify the salient assumptions and ways of seeing youth citizenship today. It suggests that we are witnessing the emergence of a form of neo-communitarian citizenship, which can be characterised as a distinct form of ‘active citizenship’ premised on neoliberal economic imperatives, resulting in a reconfiguration of youth work practice and accelerating the demise of young people’s entitlement to universal service provision.
Selecting apps for people with mild dementia: Identifying user requirements for apps enabling meaningful activities and self-management
Authors: Kerkhof YJF , Bergsma A , Graff MJL , Dröes RM
Published: June 2017

Touchscreen devices (e.g. tablets) can be supportive for people with mild dementia. This study identified user requirements for the development of a tool for selecting usable apps in the domains of self-management and meaningful activities. Eight focus groups with people with mild cognitive impairment or mild dementia and informal carers were conducted using an exploratory study design. In study one, we identified meaningful activities and self-management support. In study two, we explored needs, wishes and abilities regarding the use of apps. The outcomes were analysed using inductive content analysis based on grounded theory. Three categories were identified in study one: (1) past meaningful activities, (2) present meaningful activities and (3) self-management support. Two categories emerged from the data of study two, with two and three themes, respectively. (1) Needs and wishes of users with regard to (a) the functionality of apps and (b) technical features of apps. (2) Abilities of users in terms of (a) physical and cognitive condition, (b) independent use of apps on a tablet and (c) skills to use the touchscreen and tablet. Based on these results, we will develop filters for people with mild dementia to select apps which match their individual needs, wishes and abilities.
A framework of comparative urban trajectory analysis
Authors: Li Miaoyi , Ye Xinyue , Zhang Shanqi , Tang Xiaoyong , Shen Zhenjiang
Published: June 2017

The increasing availability of urban trajectory data from the GPS-enabled devices has provided scholars with opportunities to study urban dynamics at a finer spatiotemporal scale. Yet given the multi-dimensionality of urban trajectory dynamics, current research faces challenges of systematically uncovering spatiotemporal and societal implications of human movement patterns. Particularly, a data-driven policy-making process may need to use data from various sources with varying resolutions, analyze data at different levels, and compare the results with different scenarios. As such, a synthesis of varying spatiotemporal and network methods is needed to provide researchers and planning specialists a foundation for studying complex social and spatial processes. In this paper, we propose a framework that combines various spatiotemporal and network analysis units. By customizing the combination of analysis units, the researcher can employ trajectory data to evaluate urban built environment dynamically and comparatively. Two case studies of Chinese cities are carried out to evaluate the usefulness of proposed conceptual framework. Our results suggest that the proposed framework can comprehensively quantify the variation of urban trajectory across various scales and dimensions.
Gut microbiota regulate hepatic von Willebrand factor synthesis and arterial thrombus formation via Toll-like receptor-2
Authors: Jäckel Sven , Kiouptsi Klytaimnistra , Lillich Maren , Hendrikx Tim , Khandagale Avinash , Kollar Bettina , Hörmann Nives , Reiss Cora , Subramaniam Saravanan , Wilms Eivor , Ebner Katharina , Brühl Marie-Luise von , Rausch Philipp , Baines John F. , Haberichter Sandra , Lämmle Bernhard , Binder Christoph J. , Jurk Kerstin , Ruggeri Zaverio M. , Massberg Steffen , Walter Ulrich , Ruf Wolfram , Reinhardt Christoph
Published: June 2017

Key Points

VWF synthesis in liver endothelial cells is regulated by gut microbiota through TLR2 signaling. Reduced plasma VWF levels in GF and Tlr2−/− mice cause reduced thrombus formation at the ligation-injured carotid artery.
Obstructive sleep apnoea is not a risk factor for incident hospitalised depression: a historical cohort study
Authors: Kendzerska Tetyana , Gershon Andrea S. , Hawker Gillian A. , Tomlinson George A. , Leung Richard S.
Published: June 2017

We evaluated whether obstructive sleep apnoea (OSA) was related to the incidence of hospitalisation for depression, a robust end-point that is unlikely to result from misdiagnosis.

All adults referred with suspected OSA who underwent a diagnostic sleep study at a large urban academic hospital between 1994 and 2010 and were linked to provincial health administrative data between 1991 and 2015 were included. Cox regression analysis was used to investigate the association between OSA symptoms and severity and incident hospitalised depression, the primary outcome.

Over a median follow-up of 9.7 years, 136 (1.3%) out of 10 149 participants were hospitalised for depression. A significant crude effect of OSA symptoms (waking unrefreshed and impact on memory and concentration) on hospitalised depression became nonsignificant after controlling for confounders. Apnoea–hypopnoea index was not significantly associated with the outcome: adjusted hazard ratio (33 versus6 events·h−1) 1.13 (95% CI 0.91–1.40). Factors associated with hospitalised depression were female sex, younger age, use of hypnotics, alcoholism and unemployment.

In a large clinical cohort with suspected OSA, controlling for confounders, OSA symptoms and severity were not related to the risk of hospitalisation for depression, suggesting that previously reported links between OSA and depression may be due to overlapping diagnostic criteria. However, our findings cannot exclude a potential link between OSA and milder depression.
Chemotherapy for pulmonary large cell neuroendocrine carcinomas: does the regimen matter?
Authors: Derks Jules L. , van Suylen Robert Jan , Thunnissen Erik , den Bakker Michael A. , Groen Harry J. , Smit Egbert F. , Damhuis Ronald A. , van den Broek Esther C. , Speel Ernst-Jan M. , Dingemans Anne-Marie C. ,   PALGA group
Published: June 2017

Pulmonary large cell neuroendocrine carcinoma (LCNEC) is rare. Chemotherapy for metastatic LCNEC ranges from small cell lung carcinoma (SCLC) regimens to nonsmall cell lung carcinoma (NSCLC) chemotherapy regimens. We analysed outcomes of chemotherapy treatments for LCNEC.

The Netherlands Cancer Registry and Netherlands Pathology Registry (PALGA) were searched for patients with stage IV chemotherapy-treated LCNEC (2003–2012). For 207 patients, histology slides were available for pathology panel review. First-line platinum-based combined chemotherapy was clustered as “NSCLC-t”, comprising gemcitabine, docetaxel, paclitaxel or vinorelbine; “NSCLC-pt”, with pemetrexed treatment only; and “SCLC-t”, consisting of etoposide chemotherapy.

A panel review diagnosis of LCNEC was established in 128 out of 207 patients. NSCLC-t chemotherapy was administered in 46% (n=60), NSCLC-pt in 16% (n=20) and SCLC-t in 38% (n=48) of the patients. The median (95% CI) overall survival for NSCLC-t chemotherapy was 8.5 (7.0–9.9) months, significantly longer than patients treated with NSCLC-pt, with a median survival of 5.9 (5.0–6.9) months (hazard ratio 2.51, 95% CI 1.39–4.52; p=0.002) and patients treated with SCLC-t chemotherapy, with a median survival of 6.7 (5.0–8.5) months (hazard ratio 1.66, 95% CI 1.08–2.56; p=0.020).

In patients with LCNEC, NSCLC-t chemotherapy results in longer overall survival compared to NSCLC-pt and SCLC-t chemotherapy.
The association between chronic airflow obstruction and poverty in 12 sites of the multinational BOLD study
Authors: Townend John , Minelli Cosetta , Mortimer Kevin , Obaseki Daniel O. , Al Ghobain Mohammed , Cherkaski Hamid , Denguezli Myriam , Gunesekera Kirthi , Hafizi Hasan , Koul Parvaiz A. , Loh Li C. , Nejjari Chakib , Patel Jaymini , Sooronbayev Talant , Buist Sonia A. , Burney Peter G.J.
Published: June 2017

Poverty is strongly associated with mortality from COPD, but little is known of its relation to airflow obstruction.

In a cross-sectional study of adults aged ≥40 years from 12 sites (N=9255), participating in the Burden of Obstructive Lung Disease (BOLD) study, poverty was evaluated using a wealth score (0–10) based on household assets. Obstruction, measured as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) (%) after administration of 200 μg salbutamol, and prevalence of FEV1/FVC<lower limit of normal were tested for association with poverty for each site, and the results were combined by meta-analysis.

Mean wealth scores ranged from 4 in Blantyre (Malawi) and Kashmir (India) to 10 in Riyadh (Saudi Arabia), and the prevalence of obstruction, from 16% in Kashmir to 3% in Riyadh and Penang (Malaysia). Following adjustments for age and sex, FEV1/FVC increased by 0.36% (absolute change) (95%CI: 0.22, 0.49; p<0.001) per unit increase in wealth score. Adjustments for other confounders reduced this effect to 0.23% (0.11, 0.34), but even this value remained highly significant (p<0.001). Results were consistent across sites (I2=1%; phet=0.44). Mean wealth scores explained 38% of the variation in mean FEV1/FVC between sites (r2=0.385, p=0.031).

Airflow obstruction is consistently associated with poverty at individual and community levels across several countries.
Pilbara rock art: laser scanning, photogrammetry and 3D photographic reconstruction as heritage management tools
Authors: Davis Annabelle , Belton David , Helmholz Petra , Bourke Paul , McDonald Jo
Published: June 2017

Recording techniques such as laser scanning, photogrammetry and photographic reconstruction are not new to archaeology. However as technology evolves and becomes more readily available such methods are being more regularly employed within a cultural heritage management context, often by people with little experience in using these technologies for heritage applications. For most cultural heritage management practitioners, the awe and lure of technology and the ease with which it can bring archaeology to life can distract from the end game of managing the site on the ground. This paper examines the advantages and disadvantages of laser scanning, photogrammetry and photographic reconstruction in recording, managing and interpreting rock art sites with an emphasis on its practical applications to the field of heritage management. Using a case study from West Angelas in the East Pilbara region of Western Australia, we will examine how these technologies assist in the practical management of heritage sites, and the significant outputs achieved for Aboriginal stakeholder groups in remote access to, and the interpretation of indigenous heritage sites.
University Students’ Conceptual Knowledge of Randomness and Probability in the Contexts of Evolution and Mathematics
Authors: Fiedler Daniela , Tröbst Steffen , Harms Ute
Published: June 2017

Students of all ages face severe conceptual difficulties regarding key aspects of evolution—the central, unifying, and overarching theme in biology. Aspects strongly related to abstract “threshold” concepts like randomness and probability appear to pose particular difficulties. A further problem is the lack of an appropriate instrument for assessing students’ conceptual knowledge of randomness and probability in the context of evolution. To address this problem, we have developed two instruments, Randomness and Probability Test in the Context of Evolution (RaProEvo) and Randomness and Probability Test in the Context of Mathematics (RaProMath), that include both multiple-choice and free-response items. The instruments were administered to 140 university students in Germany, then the Rasch partial-credit model was applied to assess them. The results indicate that the instruments generate reliable and valid inferences about students’ conceptual knowledge of randomness and probability in the two contexts (which are separable competencies). Furthermore, RaProEvo detected significant differences in knowledge of randomness and probability, as well as evolutionary theory, between biology majors and preservice biology teachers.
Development and Validation of the Homeostasis Concept Inventory
Authors: McFarland Jenny L. , Price Rebecca M. , Wenderoth Mary Pat , Martinková Patrícia , Cliff William , Michael Joel , Modell Harold , Wright Ann
Published: June 2017

We present the Homeostasis Concept Inventory (HCI), a 20-item multiple-choice instrument that assesses how well undergraduates understand this critical physiological concept. We used an iterative process to develop a set of questions based on elements in the Homeostasis Concept Framework. This process involved faculty experts and undergraduate students from associate’s colleges, primarily undergraduate institutions, regional and research-intensive universities, and professional schools. Statistical results provided strong evidence for the validity and reliability of the HCI. We found that graduate students performed better than undergraduates, biology majors performed better than nonmajors, and students performed better after receiving instruction about homeostasis. We used differential item analysis to assess whether students from different genders, races/ethnicities, and English language status performed differently on individual items of the HCI. We found no evidence of differential item functioning, suggesting that the items do not incorporate cultural or gender biases that would impact students’ performance on the test. Instructors can use the HCI to guide their teaching and student learning of homeostasis, a core concept of physiology.
Checking Equity: Why Differential Item Functioning Analysis Should Be a Routine Part of Developing Conceptual Assessments
Authors: Martinková Patrícia , Drabinová Adéla , Liaw Yuan-Ling , Sanders Elizabeth A. , McFarland Jenny L. , Price Rebecca M.
Published: June 2017

We provide a tutorial on differential item functioning (DIF) analysis, an analytic method useful for identifying potentially biased items in assessments. After explaining a number of methodological approaches, we test for gender bias in two scenarios that demonstrate why DIF analysis is crucial for developing assessments, particularly because simply comparing two groups’ total scores can lead to incorrect conclusions about test fairness. First, a significant difference between groups on total scores can exist even when items are not biased, as we illustrate with data collected during the validation of the Homeostasis Concept Inventory. Second, item bias can exist even when the two groups have exactly the same distribution of total scores, as we illustrate with a simulated data set. We also present a brief overview of how DIF analysis has been used in the biology education literature to illustrate the way DIF items need to be reevaluated by content experts to determine whether they should be revised or removed from the assessment. Finally, we conclude by arguing that DIF analysis should be used routinely to evaluate items in developing conceptual assessments. These steps will ensure more equitable—and therefore more valid—scores from conceptual assessments.
Noise attenuation in a low-dimensional manifold
Authors: Yu Siwei , Osher Stanley , Ma Jianwei , Shi Zuoqiang
Published: June 2017

We have found that seismic data can be described in a low-dimensional manifold, and then we investigated using a low-dimensional manifold model (LDMM) method for extremely strong noise attenuation. The LDMM supposes the dimension of the patch manifold of seismic data should be low. In other words, the degree of freedom of the patches should be low. Under the linear events assumption on a patch, the patch can be parameterized by the intercept and slope of the event, if the seismic wavelet is identical everywhere. The denoising problem is formed as an optimization problem, including a fidelity term and an LDMM regularization term. We have tested LDMM on synthetic seismic data with different noise levels. LDMM achieves better denoised results in comparison with the Fourier, curvelet and nonlocal mean filtering methods, especially in the presence of strong noise or low signal-to-noise ratio situations. We have also tested LDMM on field records, indicating that LDMM is a method for handling relatively strong noise and preserving weak features.
HELOISE: Phase IIIb Randomized Multicenter Study Comparing Standard-of-Care and Higher-Dose Trastuzumab Regimens Combined With Chemotherapy as First-Line Therapy in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Gastric or Gastroesophageal Junction Adenocarcinoma
Authors: Shah Manish A. , Xu Rui-hua , Bang Yung-Jue , Hoff Paulo M. , Liu Tianshu , Herráez-Baranda Luis A. , Xia Fan , Garg Amit , Shing Mona , Tabernero Josep
Published: June 2017

Purpose

To compare standard-of-care (SoC) trastuzumab plus chemotherapy with higher-dose (HD) trastuzumab plus chemotherapy to investigate whether HD trastuzumab increases trastuzumab serum trough concentration (Ctrough) levels and increases overall survival (OS) in first-line human epidermal growth factor receptor 2–positive metastatic gastric or gastroesophageal junction adenocarcinoma.

Patients and Methods

Patients with Eastern Cooperative Oncology Group performance status 2, no prior gastrectomy, and ≥ two metastatic sites were randomly assigned at a one-to-one ratio to loading-dose trastuzumab 8 mg/kg followed by SoC trastuzumab maintenance 6 mg/kg every 3 weeks or loading-dose trastuzumab 8 mg/kg followed by HD trastuzumab maintenance 10 mg/kg every 3 weeks until progression; treatment in each arm was combined with cisplatin 80 mg/m2 plus capecitabine 800 mg/m2 twice per day in cycles 1 to 6. The primary objective was HD trastuzumab OS superiority (all randomly assigned patients [full-analysis set]). Final results are from an interim analysis for futility (boundary hazard ratio [HR] ≥ 0.95) at 125 deaths.

Results

At clinical cutoff, 248 patients had been randomly assigned. A marked increase in mean trastuzumab Ctrough was observed after the first HD trastuzumab cycle versus SoC trastuzumab. In the full-analysis set, median OS was 12.5 months in the SoC trastuzumab arm and 10.6 months in the HD trastuzumab arm (stratified HR, 1.24; 95% CI, 0.86 to 1.78; P = .2401). Results were similar in the per-protocol set (cycle 1 trastuzumab Ctrough < 12 µg/mL). Safety was comparable between arms.

Conclusion

HD trastuzumab maintenance dosing was associated with higher trastuzumab concentrations, no increased efficacy, and no new safety signals. HELOISE confirms standard-dose trastuzumab (loading dose of 8 mg/kg followed by 6 mg/kg maintenance dose every 3 weeks) with chemotherapy as the SoC for first-line treatment of human epidermal growth factor receptor 2–positive metastatic gastric or gastroesophageal junction adenocarcinoma.
Neurologic Complications of Cardiac and Aortic Disease
Authors: Klaas James P.
Published: June 2017

Purpose of Review: This article discusses neurologic complications that can arise from cardiac and aortic disease and dysfunction.

Recent Findings: Advances in the care of patients with cardiac or aortic disease include the use of prolonged cardiac monitoring in cryptogenic stroke and the approval of the use of left atrial appendage closure devices for stroke prevention in patients with atrial fibrillation who are not candidates for anticoagulation. Continuing controversy surrounds patent foramen ovale closure, and new evidence indicates that cognitive impairment following coronary artery bypass grafting surgery may be less common than previously thought.

Summary: Dysfunction of the cardiovascular system can cause serious neurologic injury. In some cases, both the initial presenting symptom and the most serious damage done by cardiac or aortic dysfunction may be neurologic. Prompt recognition of the symptoms, combined with recent advances in both cardiology and neurology, may permit more accurate diagnoses, more effective treatment, and less injury to patients.
Gastroenterology and Neurology
Authors: Pfeiffer Ronald F.
Published: June 2017

Purpose of Review: Just as gastrointestinal dysfunction may develop in the setting of neurologic disease, neurologic dysfunction may become evident in the setting of gastrointestinal disease. This article describes the range of neurologic features that have been described in three primary gastrointestinal diseases: celiac disease and gluten-related disorders, inflammatory bowel disease, and Whipple disease. Particular emphasis is placed on the controversial and evolving clinical picture of neurologic dysfunction in disorders of gluten sensitivity.

Recent Findings: Gluten-related disorders, including both the traditional autoimmune-based celiac disease and the more recently recognized nonautoimmune, nonallergic gluten sensitivity, have been the source of much attention in both medical and lay publications. The possible association between Crohn disease and neurologic disorders also is receiving attention. The recognition that, although Whipple disease is an exceedingly rare disorder, a surprising percentage of the population may be asymptomatic stool carriers of the causative organism makes it important to always be cognizant of the disorder.

Summary: The range of neurologic dysfunction in gastrointestinal diseases is broad and spans the spectrum from peripheral to central processes. Peripheral neuropathy, myopathy, myelopathy, cerebrovascular events, epilepsy, encephalopathy, and cerebellar dysfunction have all been described. Neurologists should be aware of the possibility that an underlying gastrointestinal disease process may be present in and responsible for the neurologic dysfunction that has prompted referral of an individual for evaluation.
Detachable Pockets and Letter Folds: Spatial Formalism and the Portable Interiors of the Eighteenth-Century Novel
Authors: Park Julie
Published: June 2017

Revisiting Richardson's Pamela as a site of “spatial formalism,” this essay maintains that the notion of the domestic interior as a setting conducive to psychological interiority requires further materialist analysis. It argues that the interiority of Pamela hinges less on characters' emotions than on its ability to move between different spatial interiors, from the oft-cited interiors of domestic architecture to the interiors of spaces that initially register as objects, such as women's detachable pockets as well as books and letters themselves. Ultimately, Pamela lays claim to her selfhood through effecting a dynamic whereby her movable possessions—her letters, her pockets in particular—become spatial territories of the self that challenge the authority of land ownership conferred to her social superiors. She effects, in other words, a shift in social relations as defined by property as well as by marriage through her ability to transform the interiority afforded by her everyday possessions into a movable estate of the self.
Zirconium-based Metal–Organic Frameworks with N-Confused Porphyrins: Synthesis, Structures, and Optical Properties
Authors: Yang Yufeng , Sakashita Ryuichi , Yamasumi Kazuhisa , Ishida Masatoshi , Yamada Teppei , Furuta Hiroyuki
Published: June 2017

Metal–organic frameworks (MOFs) composed of zirconium (Zr6) and N-confused porphyrins (NCPs) were synthesized. The cubic structures with ftw topology were determined by powder X-ray diffraction and microscopic analyses. These complexes represent high chemical stability toward various pH ranges and NIR absorption/emission derived from the NCP moieties.
Household Consumption When the Marriage Is Stable
Authors: Cherchye Laurens , Demuynck Thomas , De Rock Bram , Vermeulen Frederic
Published: June 2017

We develop a novel framework to analyze the structural implications of the marriage market for household consumption. We define a revealed preference characterization of efficient household consumption when the marriage is stable. We characterize stable marriage with intrahousehold (consumption) transfers but without assuming transferable utility. Our revealed preference characterization generates testable conditions even with a single observation per household and heterogeneous individual preferences across households. The characterization also allows for identifying the intrahousehold decision structure (including the sharing rule) under the same minimalistic assumptions. An application to Dutch household data illustrates the usefulness of our theoretical results. (JEL D60, D63, H21, H23, I38)
A Theory of Crowdfunding: A Mechanism Design Approach with Demand Uncertainty and Moral Hazard
Authors: Strausz Roland
Published: June 2017

Crowdfunding provides innovation in enabling entrepreneurs to contract with consumers before investment. Under aggregate demand uncertainty, this improves screening for valuable projects. Entrepreneurial moral hazard and private cost information threatens this benefit. Crowdfunding's after-markets enable consumers to actively implement deferred payments and thereby manage moral hazard. Popular crowdfunding platforms offer schemes that allow consumers to do so through conditional pledging behavior. Efficiency is sustainable only if expected returns exceed an agency cost associated with the entrepreneurial incentive problems. By reducing demand uncertainty, crowdfunding promotes welfare and complements traditional entrepreneurial financing, which focuses on controlling moral hazard. (JEL D21, D81, D82, D86, G32, L26)
OMBUDSMAN ACTIVITY FOR STUDENTS IN THE FIGHT AGAINST CRIME OF MINORS IN RUSSIA
Authors: Кравцова  , Kravtsova Oksana , Блинова-Сычкарь  , Blinova-Sicker Irina , Дмитриенко  , Dmitrienko Sergey
Published: June 2017

The article is devoted to the activities of the Ombudsperson for students, aimed at combating juvenile delinquency.
USING INTERACTIVE TEACHING METHODS IN THE STUDY OF MATHEMATICAL DISCIPLINES IN THE UNIVERSITY
Authors: Бикмухаметова  , Bikmukhametova D. , Миндубаева  , Mindubaeva A. , Нуриева  , Nurieva E.
Published: June 2017

The results of training in the University are inextricably linked with mastering the method of mathematical modeling as a method of studying objects of reality. This requires the improvement of the educational process, which is associated with the updating of forms of learning on an interactive basis. One of the most interesting methods that allows you to actively form professional competencies is the method of projects. This method allows you to actively use the knowledge and skills obtained in the study of mathematics and special disciplines for solving practical problems.
Características do ambiente do bairro e prática de caminhada no lazer e deslocamento em idosos
Authors: Balbé Giovane , Wathier Clair , Rech Cassiano
Published: June 2017

Este estudo teve como objetivo analisar a prevalência e as características do ambiente do bairro associadas com a caminhada no lazer e no deslocamento em idosos. Estudo transversal com 213 idosos (60 a 93 anos; 78,9% mulheres), participantes de grupos de convivência da zona urbana de Rio do Sul (SC), no ano de 2014. A caminhada no lazer e deslocamento foi avaliada utilizando a versão longa do Questionário Internacional de Atividade Física (ativo ≥150 minutos/sem). A percepção do ambiente foi mensurada a partir da versão modificada da Neighborhood Environmental Walkability Scale, composta de 13 questões sobre as características do ambiente do bairro. Adotaram-se análises de regressão logística binária bruta e ajustada, com nível de significância de 5%. A prevalência de caminhada no lazer foi de 22,1% (IC95%: 16,4-27,7) e de 28,2% (IC95%: 22,1-34,2) no deslocamento. A percepção de existência de ruas inclinadas (OR= 3,18; IC95%: 1,44-7,05) e de academias ao ar livre (OR= 0,16; IC95%: 0,04-0,70) foi associada com caminhada no lazer. No deslocamento, observou-se que maior chance de ser ativo na caminhada entre idosos que perceberam à presença de calçadas em condições de uso (OR= 3,50; IC95%: 1,48-8,28) e a presença de academias de ginástica (OR= 4,16; IC95%: 1,72-12,3). Conclui-se que menos de 30% dos idosos de Rio do Sul são ativos na caminhada no lazer e no deslocamento e, a presença de calçadas em condições adequadas de uso foi associada com o comportamento ativo na caminhada no deslocamento em idosos. Melhorar a estrutura das calçadas e diversificar os espaços para atividade física pode promover maiores níveis de caminhada em idosos.
Communication, Incentives, and the Execution of a Strategic Initiative
Authors: Hutchison-Krupat Jeremy
Published: June 2017

Senior leadership has two primary levers to influence a direct report: incentives and communication. Financial incentives are credible and precisely specified but offer limited flexibility. In contrast, communication is flexible but lacks precision, and must be deemed credible to affect a direct report’s actions. We study a setting where senior leadership seeks to add a new initiative to their organization’s portfolio. The initiative’s potential to create value is not initially well understood. Senior leadership eventually obtains more precise information on the initiative’s value and subsequently may communicate this information to their direct report. We analyze senior leadership’s incentive and communication decisions, and ultimately their portfolio decision. We find that senior leadership’s communication only affects a direct report’s actions when a new initiative’s potential to create value is sufficiently uncertain. Additionally, we find instances where an organization may benefit from communication that offers lessspecificity.

This paper was accepted by David Hsu, entrepreneurship and innovation.
A Law of Large Numbers for Limit Order Books
Authors: Horst Ulrich , Paulsen Michael
Published: June 2017

We define a stochastic model of a two-sided limit order book in terms of its key quantities best bid [ask] price and the standing buy [sell] volume density. For a simple scaling of the discreteness parameters, that keeps the expected volume rate over the considered price interval invariant, we prove a limit theorem. The limit theorem states that, given regularity conditions on the random order flow, the key quantities converge in probability to a tractable continuous limiting model. In the limit model the buy and sell volume densities are given as the unique solution to first-order linear hyperbolic PDEs, specified by the expected order flow parameters. We calibrate order flow dynamics to market data for selected stocks and show how our model can be used to derive endogenous shape functions for models of optimal portfolio liquidation under market impact.
Genes Associated with Thoracic Aortic Aneurysm and Dissection
Authors: Brownstein Adam , Ziganshin Bulat , Kuivaniemi Helena , Body Simon , Bale Allen , Elefteriades John
Published: June 2017

Thoracic aortic aneurysm (TAA) is a lethal disease, with a natural history of enlarging progressively until dissection or rupture occurs. Since the discovery almost 20 years ago that ascending TAAs are highly familial, our understanding of the genetics of thoracic aortic aneurysm and dissection (TAAD) has increased exponentially. At least 29 genes have been shown to be associated with the development of TAAD, the majority of which encode proteins involved in the extracellular matrix, smooth muscle cell contraction or metabolism, or the transforming growth factor-β signaling pathway. Almost one-quarter of TAAD patients have a mutation in one of these genes. In this review, we provide a summary of TAAD-associated genes, associated clinical features of the vasculature, and implications for surgical treatment of TAAD. With the widespread use of next-generation sequencing and development of novel functional assays, the future of the genetics of TAAD is bright, as both novel TAAD genes and variants within the genes will continue to be identified.
On skew-symmetric matrices related to the vector cross product in R^7
Authors: Beites P. , Nicolás A. , Vitória José
Published: June 2017

A study of real skew-symmetric matrices of orders $7$ and $8$, defined through the vector cross product in $\mathbb{R}^7$, is presented. More concretely, results on matrix properties, eigenvalues, (generalized) inverses and rotation matrices are established.
ARQUEOLOGIA E IDEOLOGIA. REFLEXÕES SOBRE UM TEMA INCÓMODO
Authors: Mantas Vasco Gil
Published: June 2017

A permeabilidade das ciências humanas às pressões e condicionalismos característicos de determinadas épocas ou regiões tem motivado acesas discussões, nem sempre conduzidas com a imparcialidade e o rigor exigíveis. Trata-se de um fenómeno identificável em todos os regimes, por razões políticas ou outras, com notável desenvolvimento sempre que se verifica a necessidade de reforçar ou criar identidades nacionais ou étnicas. Um dos efeito da utilização ideológica da arqueologia, envolve a destruição sistemática de património arqueológico, sobretudo quando considerado simbólico, situação que repete outras anteriores, com um agravamento de consequências ainda imprevisíveis.
LA EPIGRAFÍA, MENSAJE EN DIRECTO DE LA ANTIGÜEDAD
Authors: Rodà Isabel
Published: June 2017

El artículo recoge la intervención leída el 28 de octubre de 2015, en la sesión de homenaje al Prof. José d’Encarnação. El tema central giró en torno a los textos epigráficos que hacen llegar su voz a través de los siglos sin intermediario alguno y nos abren vías para enriquecer todas las demás ciencias de la Antigüedad. Consciente de las dificultades que hoy día presenta la docencia de la epigrafía, se proponen algunas estrategias conectando aspectos de la Antigüedad con la actualidad. Dentro de la epigrafía latina se examinan algunos ejemplos de inscripciones de la zona del territorio de Cataluña, profundizando especialmente en la red viaria, los límites territoriales y en la sociedad de la ciudad de Barcino (Barcelona).
Autoimmune Mechanisms of Cardiac Remodeling in Chronic Obstructive Pulmonary Disease
Authors: Dielievska V. , Kravchun P.
Published: June 2017

Patients with chronic obstructive pulmonary disease (COPD) have high risk of cardiovascular events due to the remodeling of the heart and vessels. We investigated whether in COPD cardiac remodeling is associated with immune response to the inflammation by studying activated T-lymphocytes, CD3+, CD4+, CD8+ subsets of T-lymphocytes autoimmune lymphocytotoxic and granulocytotoxic antibodies, circulating immune complexes, bacterial sensibilization and hypersensitivity by the delayed type to the host heart tissue antigens. It turned out that progression of COPD is characterized by the decrease of cell immunity with formation of bacterial sensibilization and autosensibilization to the heart tissue antigens, strongly associated with cardiac remodeling. Thus, the presence of autoimmune response significantly contributes to the changes of heart geometry in patients with COPD.
Psychological Well-being among Postgraduate Students
Authors: Roslan S. , Ahmad N. , Nabilla N. , Ghiami Z.
Published: June 2017

This study attempted to determine the level of psychological well-being among postgraduate students. The study also aimed to assess the relationship between psychological well-being and demographic factors, such as age and field of study. Psychological well-being questionnaires were administered to a sample of 192 Master of Education students. The findings demonstrated that Master of Education students possessed a slightly high level of psychological well-being. Differences were found in students’ psychological well-being across age groups, F (4, 167) = 3.178, p = 0.01, and field of study, F (8, 163) = 2.668, p = 0.01, respectively. According to the results, students in the age group of 41 years and above possessed the highest level of psychological well-being (M = 5, SD = 0.71).
The elliptic sinh-Gordon equation in a semi-strip
Authors: Hwang Guenbo
Published: June 2017

We study the elliptic sinh-Gordon equation posed in a
semi-strip by applying the so-called Fokas method, a
generalization of the inverse scattering transform for boundary
value problems. Based on the spectral analysis for the Lax pair
formulation, we show that the spectral functions can be
characterized from the boundary values.
We express the solution of the equation
in terms of the unique solution of the matrix Riemann–Hilbert problem
whose jump matrices are defined by the
spectral functions. Moreover, we
derive the global algebraic relation that involves the boundary
values. In addition, it can be verified that the solution of the
elliptic sinh-Gordon equation posed in the semi-strip exists if
the spectral functions defined by the boundary values satisfy this
global relation.
Orphan Disease in Structure of Recurrent Lower Respiratory Tract Diseases in Children from One To Five
Authors: Zubarenko O. V. , Koval Larisa , Doykova Katherina , Kopiyka Ganna , Skrypnyk V. V. , Lotysh Nadiya , Papinko R. M.
Published: June 2017

The paper contains structure analysis of the lower respiratory tract recurrent disease in 180 children aged one to five years, residents of Odessa, who were treated in pulmonology department of Children’s Academician BJ Reznik City Clinical Hospital.

The examinees are represented by two groups: 150 children with recurrent wheezing and 30 - with recurrent pneumonia. The selection criteria were: abnormality of central nervous system, abnormality, cystic fibrosis, congenital heart defects, tuberculosis, human immunodeficiency virus-infection.

The analysis detected that in the survey sample with recurrent lower respiratory tract disease 3.88% of children had Orphan disease. Thus in the group of children with recurrent wheezing were diagnosed 2 cases of congenital lobar hyperexpansion (ORPHA 1928), one case of lung bronchogenic cyst (ORPHA 2357), one case of pulmonary hypoplasia in the lower lobe of the left lung (ORPHA 2257), and one case of primary ciliary dyskinesia (ORPHA 98,861).

Regarding the entire structure of recurrent wheezing, most frequently was detected atopic asthma (49.33%). In 24.6% cases the cause of recurrent wheezing was associated with the otolaryngological pathology. Bronchopulmonary dysplasia was diagnosed in two children.

Recurrent pneumonia cases were differentiated if the localization of process was at the same or different places. When one-sided localization of pneumonia was established, next congenital airway malformations were diagnosed - 3 cases of congenital cystic adenomatoid malformations (type I). Genetic pathology often occurred in cases with different lesions location.

In all cases of uncertain diagnosis, predictors of recurrent lower respiratory tract diseases were revealed.
Clinical and Morphopathological Considerations in Pulmonary Hydatid Cyst Complicated by Endobronchial Rupture in Children
Authors: Dogotari N. , Gudumac Eva , Tica C. , Eremia V. , Ionescu C. , Babuci S.
Published: June 2017

The authors present a clinical case that aims to elucidate the diagnostic tactics and the efficiency of the chystostomy procedure performed in children with complicated endobronchial lung hydatid cyst and the potential serious postoperative complications that may occur in the case of this non-capitonary residual cavity technique after pulmonary echinococectomy.

Faced with the clinical, surgical and morphopathological investigations of the endobronchus ruptured lung hydatid cyst, the authors conclude that the spectra of morphological pathogenesis present in these cases are responsible for the development of persistent aerostatic disorder, resulting in a long-term postoperative morbidity, which confirms the need to optimize the methods of surgical correction of postechinococectomial residual cavities.
Comparative Cellular Local Response in Abdominal Defect Plastic Surgery with Bovine Pericardium and Bovine Fascia Preserved in Formaldehyde in Experimental Rabbits
Authors: Gudemac Eva , Babuci S. , Tica C. , Petrovici V. , Nacu V. , Ionescu C. , Negru I.
Published: June 2017

In the present paper, we refer to a method of primary closure of congenital defects of the anterior abdominal wall with tensionless viscero-abdominal disproportion. The study group included 10 animals subjected to surgery of the abdominal wall defect closure with bovine pericardium graft preserved in 0.5% formaldehyde, and 5 rabbits of the same breed and weight, in which bovine fascia graft was used as implant, being preserved in 0.5% formaldehyde. The abdominal anterior wall defect was made surgically by excision of the musculo-fascial structures and peritoneum. Bovine pericardium graft and bovine fascia graft were placed and fixed posteriorly to rectus abdominals muscles, having direct contact with the intra-abdominal contents and protected by suturing skin and subcutaneous layer.

The purpose of the study was to perform a comparative postoperative evaluation of local macroscopic and microscopic changes that develop after reconstruction of the major abdominal wall defects experimentally induced in rabbits, using bovine pericardium and bovine fascia grafts preserved in 0.5% formaldehyde.

In cases of major fascial defects of the anterior abdominal wall, bovine pericardium graft has acceptable strength and biocompatibility, having stabilizing properties of the abdominal wall due to the development of the connective tissue layer located between the implant and the subcutaneous layer. Bovine fascia grafts preserved in formaldehyde have an insignificant irritating and inflammatory action on the intestinal loops compared with bovine pericardium, and do not induce the development of a significant abdominal adhesion process, this allowing their use in the abdominal fascial defects closure with placement in direct contact with the abdominal contents.