bluuebunny/crossref_metadata_2025 huggingface dataset:
Poultry Litter Compost and NPK fertilizers Induced Growth and Yield Performance of Boro Rice at Rooftop Farming
Authors: Rahman M , Alauddin M , Turna T T , Rahman M K
Published: July 2024

The effects of inorganic fertilizers and decomposed poultry litter on the growth and yield performance of boro rice (Oryza sativa L.) were assessed by conducting a pot experiment on the rooftop of a building in Charfasson town, Bhola. The experiment was laid out in a completely randomized design (CRD), having eight treatments with three replications each. Different agronomic parameters were measured at 30-day intervals after sowing of seeds and yield parameters after harvesting. The highest height (82.67 cm) at 90d, number of leaf (37.67) at 120d, longest leaf ( 39.67 cm) at 90d, and length of panicle (27.17 cm), number of grains/panicle (153.33), weight of grain/panicle (3.74 g), fresh weight of grains (62.35 g/pot), dry weight of grain (51.53 g/pot), dry weight of root (13.43 g/pot), rice yield (51.53 g/pot) or (5.67 t ha-1), highest B:C ratio (4.51), respectively, were found in the treatment T7: (3.0 t PL ha-1 + N100P25K90 kg ha-1). The results of treatments T7 and T8 are statistically identical. The overall best growth performance and yield of boro rice were achieved in T7: (3.0 t PL ha-1 + N100P25K90 kg ha-1) treatment on a rooftop farming system on the south coast of Bangladesh.
Biodivers. Conserv. Bioresour. Manag. 2024, 10(1): 99-108
Analisis Cluster: Pedagogy Knowledge Guru Menuju Digitalisasi Pendidikan di Era Merdeka Belajar Berdasarkan Daerah Afirmasi
Authors: Ratnaya I Gede , Hajiriah Titi Laily , Fajri Siti Rabiatul , Fitriani Herdiyana
Published: July 2024

The competence possessed by teachers is an important factor in achieving learning and education goals in schools. One of the essential competencies in the learning process is pedagogical competence. The Era of Independent Learning marks a paradigm shift in education in Indonesia by utilizing technology to improve the quality of learning. However, challenges arise especially in affirmation areas that have different socio-economic conditions and educational infrastructure. This study aims to determine the ability of teachers' pedagogic competence in facing the digitalization of education in the era of Independent Learning based on affirmation areas. In addition, this study also groups teachers based on their pedagogic abilities towards the digitalization of education in the era of Freedom of Learning using cluster analysis analyzed through SPSS For Windows 23. The research sample consisted of 100 respondents from several affirmation regions in Indonesia, such as Bima, West Lombok, East Lombok, Central Lombok, Maluku, NTT, Papua, and Sumbawa. Additional respondents came from non-affirmative areas as comparators, including Mataram City, Surabaya, Kalimantan, and Magetan East Java. The results of the study show that West Lombok Regency has the highest level of pedagogic competence among affirmation areas with a score of 87.74, while Bima Regency has the lowest score of 75. This average score is still categorized as high because it is above 75. The comparison area shows that Magetan has the highest average score of 100. Cluster analysis showed the formation of two groups, namely cluster 1 consisting of teachers from Magetan, Papua, West Lombok, and NTT, and cluster 2 consisting of teachers from Kalimantan, Bima, Surabaya, Mataram City, Maluku, Sumbawa, and Central Lombok.
Identifikasi Genetik Ikan Gabus Asal Merauke dengan Menggunakan Fragmen Gen Sitokrom Oksidase Sub Unit I
Authors: Dailami Muhammad , Yuniarti Ating , Saleky Dandi , Toha Abdul Hamid A.
Published: July 2024

Efforts to cultivate snakehead fish (Chanidae) still experience many problems, especially the availability of high-quality fry. To improve the quality of fry, improving the quality of broodstock is important. Genetic factors play an important role in the selection and breeding of snakehead fish parents. Therefore, it is necessary to explore sources of superior parents with good genetic characteristics. To achieve this goal requires studies from various fields such as ecology, biology, and genetics. Genetic studies can be started by examining the identity and relationships of snakehead fish from Merauke, as a first step in finding a source of germplasm that has high diversity. The aim of this research is to analyze the cytochrome oxidase subunit 1 (COI) gene fragment of snakehead fish from Merauke, Papua. DNA isolation was carried out using the Promega kit with standard protocols, amplification of the COI gene with primers F2 and R2 with the Go Taq Green amplification kit. A total of 653 base pairs of the COI gene fragment were obtained from the sequencing process, with a nucleotide composition of T (29.9%), C (28.8%), A (24.0%), G (17.3%). BLAST results on the NCBI database show that this sequence has 100% similarity to the Channa striata sequence from Papua with sequence ID OQ405388.1. This shows that the identification results of the snakehead fish from Merauke are Channa striata. Phylogenetic tree analysis also showed consistent results, namely the formation of a clade that was the same as the Channa striata fish group derived from GenBank data.
Application of DOHaD hypothesis to the Effect of Stress Levels in Pregnant Women on the Fetus and Baby’s Mental Health: A Literature Review
Authors: Sugsihita Kafumi
Published: July 2024

Introduction: According to the research of Cadzow et al., on antepartum and postpartum mental health, weak attachment bonding between the fetus and mother during pregnancy was associated with postpartum depression and anxiety. Sugishita et al. found that postpartum depression decreased when attachment to the fetus was higher during the antepartum period. Attachment to the fetus during pregnancy was associated with maternal mental health and was associated not only during pregnancy but with postpartum depression and blood cortisol levels, which are stress indicators, cross over the placenta and have been correlated with maternal and fetal levels. It has been afraied that strong psychological stress during pregnancy has some effect on the fetus and causes mental development in children, and the fetal programming hypothesis is pointed out in the background. However, there has been no previous research on the relationship between mental health such as stress in pregnant women and the fetal programming hypothesis. The purpose of this study is to examine the relationship between stress in pregnant women and the fetal programming hypothesis through literature. Methods: The databases used in the literature search are Pubmed, CINAHL, Cochrane Library, and Google Scholar. The search range is from 2000 to 2020. The criteria for adopting the document are 'DoHaD' x 'Mental Health', 'DoHaD' x 'Stress', and 'DoHaD' x 'Depression' in the English original article registered in the retrieved database. Among the retrieved articles, duplicate documents were excluded as a result of animal experiments and genome analysis. As a result, 13 articles were selected. Results & Conclusion: As a result of conducting a literature review, it was found that when the stress of the pregnant woman is physically and psychologically high, the stress of the child is high. In particular, fetal dysfunction is likely to occur during labor if you spend pregnancy period when pregnancy complications and anxiety are strong. It is still necessary to examine the relationship between the child's growth and mental illness and the stress she received as a mother at the time of the fetus.
ANALISIS FAKTOR RISIKO GASTRO-ESOPHAGEAL REFLUX DISEASE (GERD) DI ERA PANDEMI COVID-19
Authors: Jodi Erdilian
Published: July 2024

Pendahuluan: Gastroesophageal reflux disease (GERD) merupakan kondisi patologis akibat refluks kandungan lambung ke esophagus dengan etiologi multifaktorial. Mahasiswa kedokteran memiliki risiko tinggi GERD karena kelelahan yang berlebihan terutama pada saat pandemi COVID-19. Namun, penelitian tentang faktor risiko mahasiswa kedokteran terhadap kejadian GERD pada era pandemi COVID-19 belum pernah diteliti. Oleh sebab itu, penelitian ini bertujuan untuk menganalisis faktor risiko GERD di era pandemi COVID-19 pada mahasiswa kedokteran.
Metode: Kuesioner diberikan pada mahasiswa fakultas kedokteran Universitas Brawijaya,  menggunakan google form dengan metode sampling menggunakan simple random sampling pada mahasiswa kedokteran tahap pre-klinik dan klinik. Kuesioner terdiri dari beban pendidikan, pola makan, dan psikososial-ekonomi serta kuesioner GERDQ. Analisa faktor risiko menggunakan chi-square dan regresi logistik dengan tingkat signifikasi p<0,05.
Hasil: Faktor risiko GERD pada mahasiswa kedokteran Universitas Brawijaya untuk tahap klinik yaitu lama ilmiah daring (P=0,043), terlambat makan (p=0,047), konsumsi kopi (P=0,011) dan kepuasan pencapaian ilmu (P=0,041) sedangkan mahasiswa tahap preklinik yaitu terlambat makan (p=0,009). Faktor risiko paling berpengaruh terhadap mahasiswa tahap klinik adalah konsumsi kopi (OR : 65,92; p=0,011), dan mahasiswa tahap pre-klinik adalah terlambat makan (OR: 31,09; p=0,009).
Kesimpulan: Faktor beban pendidikan, pola makan, dan psikososial-ekonomi berhubungan dengan kejadian GERD pada mahasiswa kedokteran. Faktor yang paling berpengaruh terhadap kejadian GERD adalah terlambat makan.
Kata Kunci : COVID-19, faktor risiko, GERD, mahasiswa kedokteran
ANALISIS FAKTOR YANG BERHUBUNGAN DENGAN KESEHATAN GIGI DAN MULUT PADA PASIEN SKIZOFRENIA
Authors: Bariyah Ira , Rahayu Dewi , Karyus Aila , Noviansyah Noviansyah , Budiati Endang
Published: July 2024

Pasien skizofrenia memiliki resiko tinggi mengalami masalah gigi dan mulut. Hasil observasi di RSJD Provinsi Lampung tahun 2022 diketahui dari 381 pasien 63% mengalami masalah kesehatan gigi dan mulut. Penelitian ini bertujuan menganalisis faktor yang berhubungan dengan perilaku kesehatan gigi dan mulut pada pasien skizofrenia. Jenis penelitian adalah kuantitatif dengan desain cross sectional. Sampel adalah pasien skizofrenia tahun 2022 yang berjumlah 88 pasien. Pengambilan data menggunakan kuesioner yang telah melalui uji coba. Analisis data secara univariat, bivariat dan multivariat. Hasil penelitian diketahui bahwa ada hubungan pengetahuan (p=0,000), sikap (p=0,001), pendidikan (p=0,004), aksesibilitas (p=0,007), dan peran petugas kesehatan (p=0,043) dengan kesehatan gigi dan mulut pasien skizofrenia di RSJD Provinsi Lampung. Variabel sikap merupakan variabel dominan (p=0,003; OR=5,1). Saran bagi petugas kesehatan di RSJD adalah memberikan pendidikan kesehatan gigi dan mulut yang terintegrasi dengan melibatkan tenaga medis gigi dalam tim perawatan pasien untuk memberikan perawatan gigi yang komprehensif.
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN PEMANFAATAN POSBINDU PTM DALAM IMPLEMENTASI PROGRAM POSBINDU PTM
Authors: Agusella Vera , Setiaji Bambang , Djamil Achmad , Budiati Endang , Pramudho Kodrat
Published: July 2024

Posbindu PTM adalah suatu bentuk pelayanan yang melibatkan peran serta masyarakat melalui upaya promotif dan preventif untuk mendeteksi dan mengendalikan secara dini keberadaan faktor risiko penyakit tidak menular (PTM). Tujuan penelitian ini untuk mengetahui faktor-faktor yang berhubungan dengan pemanfaatan posbindu PTM dalam implementasi program posbidu PTM Dinas Kesehatan Tulang Bawang Lampung tahun 2023.
Jenis penelitian adalah kuantitatif. Desain penelitian ini yaitu analitik korelasi. Pendekatan dalam penelitian ini yaitu pendekatan cross sectional Penelitian ini telah dilakukan di wilayah kerja Dinas Kesehatan Tulang Bawang pada 1 April 2023 â€“ 30 April 2023. Sampel minimal dalam penelitian ini berjumlah 110 responden, Analisa data digunakan, yaitu analisa univariat dan analisa bivariate dan multivariate.
Hasil analisis didapatkan tidak terdapat hubungan usia dengan pemanfaatan posbindu PTM dalam implementasi program posbidu PTM Dinas Kesehatan Tulang Bawang Lampung tahun 2023. Terdapat hubungan antara asuransi, pendapatan dan lokasidengan pemanfaatan posbindu PTM dalam implementasi program posbidu PTM Dinas Kesehatan Tulang Bawang Lampung tahun 2023.Perlu juga untuk diadakan posbindu di lebih banyak tempat agar masyarakat tidak merasa jauh dengan lokasi.
HUBUNGAN MOTIVASI KERJA DENGAN RESILIENSI PADA MAHASISWA GEN Z YANG MENGIKUTI PROGRAM MAGANG INDUSTRI
Authors: Ghazaly Virginia Arielle ,   Universitas Tarumanagara
Published: July 2024

Beberapa anggota Generasi Z (generasi yang lahir antara tahun 1997 hingga 2012), saat ini sudah menjadi mahasiswa sarjana tingkat akhir dan sedang menjalani program magang. Mengikuti perkuliahan dan magang sekaligus merupakan tantangan tersendiri bagi Gen Z yang telah menjadi mahasiswa sarjana tingkat akhir ini, terlebih Gen Z sering dijuluki sebagai “Strawberry Generation”. Beberapa penelitian menunjukkan bahwa resiliensi generasi ini lebih rendah dibandingkan Gen X yang lahir pada tahun 1965 hingga 1980. Meskipun begitu, penelitian sebelumnya menemukan bahwa beberapa faktor mampu memotivasi Gen Z dalam bekerja jika lingkungan kerjanya mendukung. Penelitian ini bertujuan untuk menguji keberadaan hubungan antara motivasi kerja dengan resiliensi pada mahasiswa magang Gen Z. Penelitian ini merupakan penelitian kuantitatif dengan metode korelasional. Sejumlah 147 sampel berpartisipasi pada penelitian ini. Hasil uji korelasi Spearman antara kedua variabel membuktikan adanya hubungan positif yang signifikan antara motivasi kerja dengan resiliensi pada mahasiswa Gen Z di Indonesia yang mengikuti magang industri (rs (147) = 0,464 dengan p = 0,000 < 0,01). Dapat disimpulkan bahwa semakin tinggi tingkat motivasi kerja pada mahasiswa Gen Z di Indonesia yang mengikuti magang industri, semakin tinggi juga tingkat resiliensinya. Sebaliknya, semakin rendah tingkat motivasi kerja mereka, semakin rendah juga tingkat resiliensinya.
Review of the American Thoracic Society (ATS) International Congress 2024
Authors: European Medical Journal
Published: July 2024

THIS year, the 2024 International Conference of the American Thoracic Society (ATS) took place in San Diego, California, USA, from May 17th–22nd. The opening ceremony began with a powerful sentiment from Maria Patricia Rivera, ATS President, spotlighting the ATS research program, which celebrates its 20th anniversary.
Association between Chewing Discomfort and Nutrient Intake in Elderly Korean Women: A Cross-Sectional Study
Authors: Park Hyo-Jeong , Park Hyun-Suk , Hwang Se-Hyun ,   The Korean Society of Oral Health Science
Published: July 2024

Objectives: The purpose of this study was to determine the relationship between chewing discomfort and nutrient intake in elderly Korean women.
Methods: A complex sample design analysis method was applied using data from the 2022 National Health and Nutrition Examination Survey to confirm the relationship between chewing discomfort and nutrient intake, nutrient density, nutritional quality index, and nutrient intake ratio.
Results: In both groups, the nutritional performance index and various optimal intake ratios for vitamin A, vitamin C, niacin, and lumps were in the range of 1.0 or less, which were relevant to the variation in chewing discomfort.
Conclusions: To manage masticatory function for balanced nutrient intake in elderly women, interest in and management of oral health is necessary.
Major Satisfaction According to Personality Type of Dental Hygiene Students
Authors: Cho Mi-Sook , Jung Jung-Hwa ,   The Korean Society of Oral Health Science
Published: July 2024

Objectives: It is to understand the personality characteristics of students through the results of MBTI personality type and major satisfaction of dental hygiene students and provide basic data for student guidance and counseling
Methods: From December 4, 2003 to March 29, 2024, 305 students enrolled in the dental hygiene department were conducted. For the data analysis of this study, the SPSS version 27.0 (IBM Crop, Armonk, USA) statistical program was used.
Results: 1. The distribution of individual preference indicators was more introverted (I), sensory (S), sensory (F), and cognitive (P) 2. The MBTI personality types appeared in the order of ISFP, ISTP, ISFJ, and INFP, ESTJ. 3. The personality type by function was the highest in the sensory (S)-emotional type (F), and the personality type by temperament was the highest in the sensory (S)-perception type (P) 4. In terms of major satisfaction according to preference trends, students in introversion (I), sensory (S), thinking (T), and judgment (J) had high major satisfaction, and major satisfaction by personality type was in the order of ESTP, ISTJ, ISFJ, and ESFP, and major satisfaction of ST by function and SJ by temperament was the highest.
Conclusions: Through the above results, it is expected that the MBTI personality type of students will be actively utilized to provide basic data on student guidance and counseling for students who may not adapt to the department.
Nôi epilepszia. 1. rész
Authors: Kelemen Anna , Juhos Vera
Published: July 2024

Az epilepszia nem provokált, visszatérô rohamokkal jellemzett, napjainkban jól kezelhetô krónikus neurológiai betegség. A betegség a felnôtt lakosság körülbelül 0,6%-át érinti, Magyarországon 25 000-30 000 nôt. Az epilepsziában szenvedô nôk éltében a rohamok és a hormonális változások egymásra való hatása problémát okozhat. A catamenialis epilepszia a rohamok gyakoriságának kétszeres növekedése a menstruációhoz köthetôen, a perimenstruálisan szedett adjuváns szerek nem helyettesítik a jól beállított kezelést. Az ösztrogének pro-, a gesztagének antikonvulzív hatásúak. Az antiepileptikumok jelentôsen befolyásolják a fogamzásgátlást, a terhesség/szoptatást és a csontok egészségét is. Az enzimindukáló antiepileptikumokat ne alkalmazzuk kombinált orális fogamzásgátló tablettákkal, hüvelygyûrûvel vagy a transdermalis tapasszal. A szintetikus ösztrogéneket tartalmazó hormonális fogamzásgátló csökkentheti a lamotriginszintet akár 50%-kal is. Az intrauterin eszköz a reverzibilis fogamzásgátlás leghatékonyabb és gyógyszerkölcsönhatás-mentes formája. A meddôség gyakori oka a polycystás petefészek szindróma, valproathoz köthetô zavar. Enziminduktor antiepilektumokat szedô nôknél a csontsûrûséget ellenôrizni kell, és D-vitamin-pótlást szükséges indikálni.
Célzott terápiák a reumatológiai gyakorlatban: előnyök és hátrányok
Authors: Vereckei Edit
Published: July 2024

A gyulladásos és autoimmun betegségek klinikai képét a proinflammatorikus citokinek és receptoraik hálózata és a kapcsolódó sejteken belüli jeltovábbító fehérjék specificitása alakítja ki. Az autoimmun, immunközvetített gyulladásos és az autoinflammatiós kórképek és szindrómák patomechanizmusai és szöveti reakciói összetett és sokarcú tünetegyütteseket hoznak létre. A citokin-szignáltranszdukció hierarchikusan épül fel, ezen belül csomópontok és elágazások határozhatók meg. A rendszer elemei párbeszédet folytatnak és homeosztatikus önszabályozó kapcsolatban állnak egymással. A citokinhálózat és a klinikai képek mátrixban ábrázolhatók. A szabályozás autoagresszív felbomlása vezet a patológiás állapot kialakulásához. A patogenezis központi tényezôinek farmakológiai gátlása az innovatív célzott terápia. Eszközei tervezett komplementer protein makromolekulák (géntechnológiai úton elôállított monoklonális ellenanyagok és receptoranalógok vagy -fúziós proteinek), valamint ugyancsak célpontra tervezett kismolekulájú enzimgátlók. Korábban nem tapasztalt hatásossággal és irányítható toxicitással mélyrehatóan megváltoztatják a célbetegségek természetrajzát és remiszsziónak megfelelô vagy azt megközelítô állapotokat eredményeznek. A tanulmány a megcélzott mechanizmusokat és betegségeket, valamint a gátló készítményeket mutatja be.
Обоснование процесса выбора организационно-технологических решений
Authors: ЛАПИДУС Азарий Абрамович , ОЛЕЙНИК Павел Павлович
Published: July 2024

Рассмотрены два подхода к выбору наилучших решений - математический и прикладной. Математический подход представлен как определение экстремума функции на некотором отрезке. Прикладной подход изложен в виде различных оценок организационно-технологических решений. Приведен перечень используемых для этого основных, локальных и индивидуальных показателей и их сочетаний. Отмечена существующая практика всесторонней оценки организационно-технологических решений, которая успешно применяется при организации строительства отдельных объектов и их комплексов, формировании сводного проекта организации работ на производственную программу строительной организации, разработке документации по оперативно-производственному планированию. Показаны принципиальные отличия процессов оптимизации организационно-технологических решений при математическом и прикладном подходах с выводом о нецелесообразности использования термина "оптимизация организационно-технологических решений" в прикладных исследованиях. Предложены синонимы этого термина и скорректировано понятие "оптимизация организационно-технологических решений".
Критерии надежности железобетонных конструкций при взрывных нагрузках
Authors: КЕЛАСЬЕВ Николай Геннадьевич , АВДЕЕВ Кирилл Владимирович , ЛЕВИН Дмитрий Иванович
Published: July 2024

Рассмотрены критерии надежности железобетонных конструкций, подверженных действию внешнего взрыва, которые используются в отечественных и зарубежных нормах. Проведены численные расчеты на примере однопролетной шарнирно-опертой балки двумя методами: упрощенным с использованием эквивалентной статической нагрузки и коэффициента динамичности, а также более сложным методом, основанным на решениях уравнений движения во временной области. Расчет выполнен по предельному состоянию, по которому допускаются пластические деформации в арматуре и деформирование бетона на нисходящем участке диаграммы деформирования. Представлена сравнительная таблица результатов по предложенным методам расчета. Определены основные критерии оценки надежности железобетонных конструкций при расчете с помощью уравнений движения во временной области на действие внешнего взрыва.
Gambaran Tingkat Stres, Kecemasan, dan Depresi Mahasiswa dalam Persiapan Menghadapi Ujian Osce (Objective Structured Clinical Examination)
Authors: Ramadini Indri , Yanti Nova
Published: July 2024

The competency test is an assessment of the abilities of Indonesian nurse graduates using written test methods via Computer Based Test (CBT) and Paper Based Test (PBT) as well as the Objective Structured Clinical Examination (OSCE) method. The results of researchers' interviews with D3 Nursing and Nursing students found that almost 86% experienced anxiety and stress. The aim of this research is to identify the level of stress, anxiety and depression of students when facing the OSCE. The research design uses a descriptive method, the sample is 85 people (56 D3 Nursing students, 26 Nursing students). Scale. Results of analysis of student stress levels were 31.76% normal, 17.65% mild, 21.18% moderate, 12.94% severe, and 16.47% very severe. Analysis of student anxiety levels 38.82% normal .12% mild, 24.71% moderate, 10.59% severe, and 11.76 very severe. Meanwhile, analysis of depression levels was 56.47% normal students, 15.29% mild, 11.76% moderate, 3.53. % by weight, and 12.94% by weight. The conclusion of this research is that the level of stress, anxiety and depression among students is mostly at normal levels, but there are still students at severe and very severe levels. It is recommended that educational institutions carry out stress, anxiety and depression management to eliminate negative influences as a relaxation effort that can change the situation to neutral.
Опыт подготовки пространственных данных для решения задач трехмерного моделирования объектов недвижимости
Authors: Брылев Игорь Сергеевич , Бударова Валентина Алексеевна , Елисеева Наталья Сергеевна
Published: July 2024

Целью работы является реализация решения по формированию трехмерной базы данных городского пространства с применением современных методов геодезической съемки и программного обеспечения. Объектом исследования выбран флигель дома В. П. Буркова, расположенный по адресу: Тюменская область, город Тюмень, улица Дзержинского, 30, строение 2, который имеет статус выявленного объекта культурного наследия, так как является частью усадьбы В. П. Буркова. Для получения пространственных данных объекта исследования была выполнена геодезическая съемка при помощи GNSS-приемника от EFT GROUP M5 RUS, а также было проведено натурное обследование флигеля дома В. П. Буркова. Далее была разработана и реализована технологическая схема создания 3D-модели по материалам наземной фотограмметрической съемки местности. Данный подход может быть применен для формирования трехмерной базы данных пространства города Тюмени.
Методика автоматизированного дешифрирования нефтяных загрязнений для территории Ханты-Мансийского автономного округа – Югры
Authors: Белова Юлия Владимировна , Добрякова Валентина Аркадьевна , Козлова Дарья Владимировна , Исаева Владислава Олеговна , Гетман Кирилл Викторович
Published: July 2024

В работе предложена, а затем протестирована методика дешифрирования нефтяных загрязнений для территории ХМАО – Югры автоматизированными методами в программном комплексе ERDAS Imagine 2015. Подбор методики осуществлялся на основе данных спутника Landsat 5 за 2011 г. на территорию Ершового месторождения. Для оценки качества классификации использованы данные о фактических площадях и локализации нефтяных разливов в 2011 г. Предлагаемая методика включает в себя подготовку исходных данных, создание мультиспектрального изображения в комбинации каналов RED-NIR-SWIR, создание обучающей выборки для классов объектов, классификацию мультиспектрального изображения методом Maximum Likelihood, оценку качества классификации. Предложенная схема дешифрирования может применяться для оценки последствий аварий, связанных с утечкой нефти при ее добыче и транспортировке в условиях заболоченной местности Западной Сибири.
Сравнительный анализ программных инструментов создания карт-историй
Authors: Карташова Ксения Валерьевна , Колесников Алексей Александрович
Published: July 2024

В наши дни многие пользователи, не имеющие специальной подготовки в области картографии и опыта в веб-дизайне, в состоянии создать несложную интерактивную карту, размещенную на одностраничном сайте, благодаря появлению специализированных веб-сервисов с различными функциональными возможностями и наборами шаблонов. В последние годы среди веб-карт появился новый вид, называемый картами-историями (сюжетные карты, Story Maps). Такие карты могут быть созданы как с помощью уже существующих веб-сервисов (конструкторов карт), так и самостоятельно. Цель настоящего исследования – осуществить поиск, изучить и выполнить сравнительный анализ типовых инструментов создания и использования карт-историй, выявить их сильные и слабые стороны, выделить основные признаки и особенности таких карт. В работе рассматриваются как существующие инструменты создания карт-историй с помощью веб-сервисов, так и возможности разработки таких карт самостоятельно с использованием открытого программного обеспечения. Приведен сравнительный анализ функциональных возможностей веб-сервисов ArcGIS StoryMaps и Knightlab StoryMap JS по созданию карт-историй. Также проанализированы веб-инструменты по созданию временных шкал – Knightlab Timeline JS и Tiki Toki.
Respon Warganet Mengenai Pernikahan Beda Agama
Authors: Riesardhy Anastasia Winanti
Published: July 2024

Abstrak. Respon warganet terhadap video YouTube Cretivox 'Suami Kristen, Istri Islam' cenderung positif. Namun, ada juga respon yang berseberangan dengan pandangan tersebut. Beberapa warganet berpendapat bahwa pernikahan beda agama tidak patut dilakukan, terutama karena bertentangan dengan nilai agama Islam. Ada juga yang memberikan saran agar pernikahan beda agama tidak dilakukan sebagai tindakan preventif. Warganet juga membagikan pengalaman mereka terkait pernikahan beda agama yang sudah berlangsung. Ada juga warganet yang masih ragu atau akan melaksanakan pernikahan beda agama. Dalam episode "Suami Kristen, Istri Islam", terlihat bahwa warganet berada dalam lingkup sphere of legitimate controversy. Sphere of legitimate controversy adalah ranah kontroversi yang sah yang terdiri dari isu-isu dan sudut pandang yang dianggap layak diperdebatkan di dalam arus utama media dan dapat disetujui atau tidak disetujui oleh masyarakat. Dalam hal ini, terdapat berbagai pandangan yang mendukung maupun bertentangan dengan pernikahan beda agama. Namun, perlu diingat bahwa lingkup sphere of legitimate controversy harus dijaga dengan hati-hati karena ada warganet yang menggunakan kata-kata yang tidak pantas dalam ruang publik. Terutama di Indonesia, yang mayoritas beragama Islam, topik perbedaan agama menjadi sangat kontroversial dan masuk dalam lingkup sphere of legitimate controversy.
A ressignificação do “fenômeno” de caça às bruxas
Authors: Mac Knight Erika
Published: July 2024

O “fenômeno” de caça às bruxas na sociedade ocidental ocorrido durante os séculos XVI a XVII, foi tirado da clandestinidade a partir da segunda onda do Movimento Feminista em meados da década de 1970, e vem sendo debatido nos dias atuais sob o entendimento de uma perseguição intencional à um grupo de mulheres que naquele período detinham conhecimentos sobre a reprodução (parteiras), eram curandeiras e herboristas, ou simplesmente prostitutas e mendigas. Com essa premissa, o presente artigo tem como intuito trilhar historicamente uma compreensão do por que milhares de mulheres foram julgadas, torturadas, enforcadas ou queimadas vivas por quase dois séculos na Europa e correlacionar com o filme de horror hollywoodiano Rua do medo: 1666 – Parte 3, da diretora Leigh Janiak, lançado em 2021 na plataforma de streaming Netflix. A escolha por tal narrativa cinematográfica deve-se pelo motivo de observar na mesma a possibilidade de uma nova leitura sobre tal acontecimento sob o ponto de vista da suposta bruxa e o beneficiário de tal acusação.
The mechanism of Gejie Zhilao Pill in treating tuberculosis based on network pharmacology and molecular docking verification
Authors: Gao Yuhui , Shang Bingbing , He Yanyao , Deng Wen , Wang Liang , Sui Shaoguang
Published: July 2024

Introduction

Gejie Zhilao Pill (GJZLP), a traditional Chinese medicine formula is known for its unique therapeutic effects in treating pulmonary tuberculosis. The aim of this study is to further investigate its underlying mechanisms by utilizing network pharmacology and molecular docking techniques.

Methods

Using TCMSP database the components, potential targets of GJZLP were identified. Animal-derived components were supplemented through the TCMID and BATMAN-TCM databases. Tuberculosis-related targets were collected from the TTD, OMIM, and GeneCards databases. The intersection target was imported into the String database to build the PPI network. The Metascape platform was employed to carry out Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis. Heatmaps were generated through an online platform (https://www.bioinformatics.com.cn). Molecular docking was conducted between the core targets and core compounds to explore their binding strengths and patterns at the molecular level.

Results

61 active ingredients and 118 therapeutic targets were identified. Quercetin, Luteolin, epigallocatechin gallate, and beta-sitosterol showed relatively high degrees in the network. IL6, TNF, JUN, TP53, IL1B, STAT3, AKT1, RELA, IFNG, and MAPK3 are important core targets. GO and KEGG revealed that the effects of GJZLP on tuberculosis mainly involve reactions to bacterial molecules, lipopolysaccharides, and cytokine stimulation. Key signaling pathways include TNF, IL-17, Toll-like receptor and C-type lectin receptor signaling. Molecular docking analysis demonstrated a robust binding affinity between the core compounds and the core proteins. Stigmasterol exhibited the lowest binding energy with AKT1, indicating the most stable binding interaction.

Discussion

This study has delved into the efficacious components and molecular mechanisms of GJZLP in treating tuberculosis, thereby highlighting its potential as a promising therapeutic candidate for the treatment of tuberculosis.
Emergence of a clinical Klebsiella pneumoniae harboring an acrAB-tolC in chromosome and carrying the two repetitive tandem core structures for blaKPC-2 and blaCTX-M-65 in a plasmid
Authors: He Long , Wang Wenji , Ma Liman , Wang Dongguo , Long Shanshan
Published: July 2024

Objective

The emergence of clinical Klebsiella pneumoniae strains harboring acrAB-tolC genes in the chromosome, along with the presence of two repetitive tandem core structures for blaKPC-2 and blaCTX-M-65 genes on a plasmid, has presented a significant clinical challenge.

Methods

In order to study the detailed genetic features of K. pneumoniae strain SC35, both the bacterial chromosome and plasmids were sequenced using Illumina and nanopore platforms. Furthermore, bioinformatics methods were employed to analyze the mobile genetic elements associated with antibiotic resistance genes.

Results

K. pneumoniae strain SC35 was found to possess a class A beta-lactamase and demonstrated resistance to all tested antibiotics. This resistance was attributed to the presence of efflux pump genes, specifically acrAB-tolC, on the SC35 chromosome. Additionally, the SC35 plasmid p1 carried the two repetitive tandem core structures for blaKPC-2 and blaCTX-M-65, as well as blaTEM-1 with rmtB, which shared overlapping structures with mobile genetic elements as In413, Tn3, and TnAs3. Through plasmid transfer assays, it was determined that the SC35 plasmid p1 could be successfully transferred with an average conjugation frequency of 6.85 × 10-4.

Conclusion

The structure of the SC35 plasmid p1 appears to have evolved in correlation with other plasmids such as pKPC2_130119, pDD01754–2, and F4_plasmid pA. The infectious strain SC35 exhibits no susceptibility to tested antibioticst, thus effective measures should be taken to prevent the spread and epidemic of this strain.
Healthy and diabetic primary human osteoblasts exhibit varying phenotypic profiles in high and low glucose environments on 3D-printed titanium surfaces
Authors: Allen Nicholas , Aitchison Alexandra Hunter , Abar Bijan , Burbano Julian , Montgomery Mark , Droz Lindsey , Danilkowicz Richard , Adams Samuel
Published: July 2024

Background

The revolution of orthopedic implant manufacturing is being driven by 3D printing of titanium implants for large bony defects such as those caused by diabetic Charcot arthropathy. Unlike traditional subtractive manufacturing of orthopedic implants, 3D printing fuses titanium powder layer-by-layer, creating a unique surface roughness that could potentially enhance osseointegration. However, the metabolic impairments caused by diabetes, including negative alterations of bone metabolism, can lead to nonunion and decreased osseointegration with traditionally manufactured orthopedic implants. This study aimed to characterize the response of both healthy and diabetic primary human osteoblasts cultured on a medical-grade 3D-printed titanium surface under high and low glucose conditions.

Methods

Bone samples were obtained from six patients, three with Type 2 Diabetes Mellitus and three without. Primary osteoblasts were isolated and cultured on 3D-printed titanium discs in high (4.5 g/L D-glucose) and low glucose (1 g/L D-Glucose) media. Cellular morphology, matrix deposition, and mineralization were assessed using scanning electron microscopy and alizarin red staining. Alkaline phosphatase activity and L-lactate concentration was measured in vitro to assess functional osteoblastic activity and cellular metabolism. Osteogenic gene expression of BGLAP, COL1A1, and BMP7 was analyzed using reverse-transcription quantitative polymerase chain reaction.

Results

Diabetic osteoblasts were nonresponsive to variations in glucose levels compared to their healthy counterparts. Alkaline phosphatase activity, L-lactate production, mineral deposition, and osteogenic gene expression remained unchanged in diabetic osteoblasts under both glucose conditions. In contrast, healthy osteoblasts exhibited enhanced functional responsiveness in a high glucose environment and showed a significant increase in osteogenic gene expression of BGLAP, COL1A1, and BMP7 (p<.05).

Conclusion

Our findings suggest that diabetic osteoblasts exhibit impaired responsiveness to variations in glucose concentrations, emphasizing potential osteoblast dysfunction in diabetes. This could have implications for post-surgery glucose management strategies in patients with diabetes. Despite the potential benefits of 3D printing for orthopedic implants, particularly for diabetic Charcot collapse, our results call for further research to optimize these interventions for improved patient outcomes.
A hierarchical game framework for peer-to-peer energy trading in distribution networks considering the participation of prosumers
Authors: Song Zhenhao , Lv Zhipeng , Jia Bingjian , Li Hao , Yang Fei
Published: July 2024

The advent of the peer-to-peer energy trading has dramatically altered the conventional dynamics of distribution networks. Prosumers, managing independently and engaging in peer-to-peer (P2P) energy exchanges, introduce critical challenges for the economical and secure operations of these networks. This research presents a hierarchical framework designed to manage P2P energy interactions between prosumers and to facilitate flexible operation within the distribution network at the substation level. The upper layer of the model aims to stabilize market prices within the distribution framework, while the lower layer establishes a P2P energy trading platform that upholds fairness and safeguards the privacy of the prosumer participants. A fixed-point mapping approach is utilized to assess the interactions between market stabilization efforts and prosumer bidding strategies within this framework. Through simulations, we illustrate the logical soundness and effectiveness of our proposed model and approach. The findings indicate that the proposed model and the energy trading framework could substantially improve the overall welfare of all stakeholders involved.
Effects of rubber intercropping with native trees on litterfall and litter main nutrient return in Hainan Island, China
Authors: Qi Dongling , Wu Zhixiang , Sun Rui , Yang Chuan , Zhang Xian , Li Shaobin , Che Xiufen
Published: July 2024

Understanding the process of litterfall production is crucial for sustainable development of plantations. However, the underlying dynamics of litterfall and its nutrient return in plantation agroforestry systems remain unclear. In this study, we investigated litterfall, including leaves, branches, flowers, and fruits, in three patterns: Hevea monoculture system (RM), Hevea–Michelia intercropping system (RAS1), and Hevea–Mytilaria intercropping system (RAS2) in Hainan Island, China. Our findings indicate that total litterfall was significantly higher in RAS1 (27,309 kg ha−1) and RAS2 (34,477 kg ha−1) than in RM (22,364 kg ha−1) and was predominantly composed of leaf litterfall in all three patterns, followed by branches, flowers, and fruits. The seasonal dynamics litterfall production of RM, RAS1, and RAS2 showed characteristic patterns. Litterfall nutrients exhibited peak and sub-peak monthly dynamics, peaking from February to March, during the dry season. Total nitrogen (TN), total phosphorus (TP), and total potassium (TK) content of annual litterfall in RAS1 significantly increased by 120 kg ha−1, 30 kg ha−1, and 139 kg ha−1, respectively, compared to those in RM, with percentage increases of 67.88%, 122.79% and 96.27%, respectively. Similarly, TN, TP, and TK content of annual litterfall in RAS2 significantly increased by 185 kg ha−1, 35 kg ha−1, and 170 kg ha−1, respectively, with percentage increases of 103.70%, 159.15% and 139.46%, respectively, for the abovementioned in RM. Litterfall showed a strong correlation with monthly average temperature, monthly minimum temperature, and monthly average wind speed, contributing 80.5%, 75.5%, 69.8%, and 69.6% to the total litterfall and its components, respectively. Further analysis indicated that monthly average temperature, monthly minimum temperature, and monthly average wind speed contributed 73.9%, 43.0%, and 66.6%, respectively, to TN, TP, and TK content of the annual litterfall, highlighting the significant influence of temperature and wind speed. These findings enhance our understanding of carbon and nutrient cycling and contribute to the sustainable management of tropical plantation ecosystems.
Proteomic analysis of granulomas from cattle and pigs naturally infected with Mycobacterium tuberculosis complex by MALDI imaging
Authors: Larenas-Muñoz Fernanda , Sánchez-Carvajal José María , Ruedas-Torres Inés , Álvarez-Delgado Carmen , Fristiková Karola , Pallarés Francisco José , Carrasco Librado , Chicano-Gálvez Eduardo , Rodríguez-Gómez Irene Magdalena , Gómez-Laguna Jaime
Published: July 2024

Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) has recently gained prominence for its ability to provide molecular and spatial information in tissue sections. This technology has the potential to uncover novel insights into proteins and other molecules in biological and immunological pathways activated along diseases with a complex host–pathogen interaction, such as animal tuberculosis. Thus, the present study conducted a data analysis of protein signature in granulomas of cattle and pigs naturally infected with the Mycobacterium tuberculosis complex (MTC), identifying biological and immunological signaling pathways activated throughout the disease. Lymph nodes from four pigs and four cattle, positive for the MTC by bacteriological culture and/or real-time PCR, were processed for histopathological examination and MALDI-MSI. Protein identities were assigned using the MaTisse database, and protein–protein interaction networks were visualized using the STRING database. Gene Ontology (GO) analysis was carried out to determine biological and immunological signaling pathways in which these proteins could participate together with Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis. Distinct proteomic profiles between cattle and pig granulomas were displayed. Noteworthy, the GO analysis revealed also common pathways among both species, such as “Complement activation, alternative pathway” and “Tricarboxylic acid cycle”, which highlight pathways that are conserved among different species infected by the MTC. In addition, species-specific terms were identified in the current study, such as “Natural killer cell degranulation” in cattle or those related to platelet and neutrophil recruitment and activation in pigs. Overall, this study provides insights into the immunopathogenesis of tuberculosis in cattle and pigs, opening new areas of research and highlighting the importance, among others, of the complement activation pathway and the regulation of natural killer cell- and neutrophil-mediated immunity in this disease.
Internal organs and body tissues of free-swimming whale sharks (Rhincodon typus) imaged using underwater ultrasound
Authors: Meekan M. G. , Thompson F. , Brooks K. , Matsumoto R. , Murakumo K. , Lester E. , Dove A. , Hopper B.
Published: July 2024

Ultrasound imaging can be used as an effective tool to measure the reproductive status and condition of sharks. This usually requires restraint of the subject, which is not feasible in the wild when the target species is of conservation concern and very large, as is the case for whale sharks. Our study invoked a behavioral response in free-swimming whale sharks that allowed snorkelers to image internal organs and structures using a submersible ultrasound scanner linked to an iPhone in an underwater housing. We were able to reliably locate and monitor the heart and other internal organs inside the body cavity, structures inside the head, and image skin and muscle in the dorsal surface of the sharks. The technique is evaluated as a means for assessing the condition and reproductive status of free-swimming whale sharks.
Causality of metabolites and metabolic pathways on cholestatic liver diseases: a Mendelian randomization study
Authors: Wei Zhengxiao , Liu Yingfen , Xiong Qingqing , Mei Xue , Li Jinghong , Wu Zhangjun
Published: July 2024

Background and Aims

Blood metabolite abnormalities have revealed an association with cholestatic liver diseases (CLDs), while the underlying metabolic mechanisms have remained sluggish yet. Accordingly, the present evaluation aims to investigate the causal relationship between blood metabolites and the risk of two major CLDs, including primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC).

Methods

Univariable and multivariable Mendelian randomization (MR) approaches were employed to uncover potential causal associations between blood metabolites and 2 CLDs, including PBS and PSC, through extracting instrumental variables (IVs) for metabolites from genome-wide association studies (GWAS) conducted on European individuals. The GWAS summary data of PBC or PSC were sourced from two distinct datasets. The initial analysis employed inverse variance weighted (IVW) and an array of sensitivity analyses, followed by replication and meta-analysis utilizing FinnGen consortium data. Finally, a multivariable MR analysis was carried out to ascertain the independent effects of each metabolite. Furthermore, the web-based tool MetaboAnalyst 5.0 was used to perform metabolic pathway examination.

Results

A genetic causality between 15 metabolites and CLDs was recognized after preliminary analysis and false discovery rate (FDR) correction. Subsequently, 9 metabolites consistently represented an association through replication and meta-analysis. Additionally, the independent causal effects of 7 metabolites were corroborated by multivariable MR analysis. Specifically, the metabolites isovalerylcarnitine (odds ratio [OR] = 3.146, 95% confidence intervals [CI]: 1.471–6.726, p = 0.003), valine (OR = 192.44, 95%CI: 4.949–7483.27, p = 0.005), and mannose (OR = 0.184, 95%CI: 0.068–0.499, p < 0.001) were found to have a causal relationship with the occurrence of PBC. Furthermore, erythrose (OR = 5.504, 95%CI: 1.801–16.821, p = 0.003), 1-stearoylglycerophosphocholine (OR = 6.753, 95%CI: 2.621–17.399, p = 7.64 × 10−5), X-11847 (OR = 0.478, 95%CI: 0.352–0.650, p = 2.28 × 10−6), and X-12405 (OR = 3.765, 95%CI: 1.771–8.005, p = 5.71 × 10−4) were independently associated with the occurrence of PSC. Furthermore, the analysis of metabolic pathways identified seven significant pathways in two CLDs.

Conclusion

The findings of the present study have unveiled robust causal relationships between 7 metabolites and 2 CLDs, thereby providing novel insights into the metabolic mechanisms and therapeutic strategies for these disorders.