bluuebunny/crossref_metadata_2025 huggingface dataset:
KOBİGEL Destek Programı Değerlendirme Modeli:AHP Tabanlı Swara Yaklaşımı İle Yeni Bir Model
Authors: Sevinç Ali , Eren Tamer
Published: April 2024

Küçük ve Orta Boy İşletmeler (KOBİ'ler), ekosistemin önemli bir parçasını oluşturarak ekonomide katma değeri yükselten kilit aktörlerdir. Bu nedenle, KOBİ'lerin ekonomik büyümeye ve istihdama olan katkısı büyük bir öneme sahiptir. Ülke çapında bu işletmelerin gelişimini desteklemek amacıyla KOSGEB, KOBİ'lerin rekabet gücünü artırmayı hedefleyen KOBİ Gelişim Destek Programı (KOBİGEL) kapsamında çağrı yöntemiyle destek sağlamaktadır.
Bu çalışmanın amacı, KOSGEB'in KOBİGEL destek programı kapsamında dijitalleşme çağrısına yönelik etkili değerlendirme kriterleri oluşturmak ve puanlama sistemi geliştirmektir. Değerlendirme kriterlerini belirlemek için, ilk olarak literatür araştırması yapılmıştır. Araştırma sonuçlarına dayanarak belirlenen ana ve alt değerlendirme kriterleri daha sonra uzman görüşlerine sunulmuş ve dijitalleşme çağrısı için uygun kriterler oluşturulmuştur. Bu kriterler, Analitik Hiyerarşi Süreç (AHP) tabanlı ve Step-Wise Weight Assessment Ratio Analysis (SWARA) yöntemi kullanılarak ağırlıklandırılmış ve puanlandı. Bu değerlendirme sonucunda, Dijital Kültür ve Yetenek kriteri %23 ile en yüksek puanı almış, ardından firmanın teknolojik altyapısı kriteri %22, Dijitalleşme Stratejisi kriteri %20, Yönetişim kriteri %17 ve Dijitalleşme için Kaynak Durumu kriteri %17 puanla sıralanmıştır. Bu sayede KOBİGEL destek programı için dijitalleşme çağrısı değerlendirme kriterleri belirlenmiş ve puanlama sistemi oluşturulmuştur.
Müşteri ile Bağ Kurma Çerçevesinde Web Sitesi Hizmet Belirleyicilerinin Değerlendirilmesi
Authors: Sarıtaş Emel
Published: April 2024

Günümüzün tek tıkla alışveriş imkanı sağlayan web siteleri markaların internet ortamındaki vitrinleri olarak değerlendirilmekte, kurumsal kimliğini oluşturmaya çalışan işletmeler için iyi tasarlanmış web siteleri güçlü ve güvenilir görünmenin önemli öğelerinden biri olarak kabul edilmektedir. İşletmelerin İnternet ortamındaki görünen yüzü, etkili bir tanıtım aracı ve müşteri ile buluşma mecraları olarak değerlendirilen web sitelerinin sahip oldukları özellikleri değerlendirerek, tüketici davranışlarını hangi açılardan desteklediğini analiz etmek önem arzetmektedir. Fiziksel mağazalarda olduğu gibi web siteleri de sahip oldukları özellikleri ile ziyaretçilerini uzun süreli web sitesinde kalmaya ikna etmeye ve tüketici ile bağ bileşenlerinden olan bilişsel, duygusal ve davranışsal tutumu oluşturmayı hedeflemektedir. Tüketicilerin bilişsel, duygusal ve davranışsal açıdan bağ kurmayı web sitelerinin sahip oldukları özelliklerin katkı sağlayıp sağlamadığı bu araştırmanın konusudur. Bu kapsamda özel alışveriş sitelerinin web sitelerini değerlendirilmek üzere anket çalışması yapılmıştır. Elde edilen veriler SPSS veri analiz programı ile analiz edilmiştir. Özel alışveriş sitelerindeki kişiselleştirme ve teşvik unsurlarının bağ kurma bileşenleri olan bilişsel, duygusal ve davranışsal bileşenlerinin tümünde olumlu etkiye sahip olduğu görülmektedir.
Nisan 2024 Editoryal
Authors: Üniversitesi Yaşar
Published: April 2024

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Assessing the Impact of Blockchain Technology on Financial Reporting and Audit Practices
Authors: Danach Kassem , Hejase Hussin Jose , Faroukh Ahmad , Fayyad-Kazan Hasan , Moukadem Imad
Published: April 2024

The significant influence of blockchain technology on contemporary financial reporting and auditing procedures is examined in this paper. The rapid spread of blockchain technology brought about a new era in financial data management, which can completely transform the accounting ecosystem's efficiency, security, and transparency. This study explores the various ramifications of blockchain adoption in accounting, concentrating on how it affects regulatory compliance, audit trail integrity, cost-effectiveness, smart contracts, and financial reporting accuracy. This study aims to clarify blockchain technology's advantages and challenges to accounting professionals, regulators, and auditors by analyzing its disruptive potential. With the help of growing regulatory frameworks and real-world use examples, it offers a thorough grasp of how financial reporting and auditing processes are changing in the blockchain era. The study also emphasizes the significance of understanding how blockchain technology changes traditional accounting practices as more companies incorporate it into their financial operations. It draws attention to the benefits of blockchain technology. Also, it emphasizes the need for flexibility and compliance with legal requirements to fully realize its potential in the fields of audit assurance and financial reporting. This investigation allowed us to provide accounting managers, professionals, policymakers, and other stakeholders with priceless knowledge of the potential for blockchain technology to revolutionize the accounting industry.
Peningkatan Kejujuran Akademik pada Mahasiswa melalui Pelatihan Pendidikan Anti Korupsi
Authors: Putri Putri Pusvitasari , Heryadi Adi , Puspitasari Dian
Published: April 2024

Mahasiswa mungkin memang dilihat tidak sama sekali melakukan tindak korupsi terhadap uang negara, namun pelanggaran yang mereka lakukan adalah tidak bertanggungjawab atas apa yang telah diamanahkan kepadanya terutama dalam konteks akademik. Apabila diposisikan secara setara, maka kondisi seperti ini sangat berpotensi membuat mahasiswa untuk melakukan tindak korupsi yang sama dengan pejabat publik. Berangkat dari permasalahan tersebut, maka diperlukan sebuah intervensi atau tritmen khusus untuk meningkatkan kejujuran akademik mahasiswa, salah satunya dengan pelatihan pendidikan anti korupsi. Penelitian ini bertujuan untuk melihat seberapa efektif pelatihan pendidikan anti korupsi dalam meningkatkan kejujuran akademik pada mahasiswa. Metode penelitian yang digunakan adalah eksperimen dengan sasaran subjek 22 orang mahasiswa aktif Prodi Psikologi Unjani Yogyakarta. Desain eksperimen yang digunakan dalam penelitian ini adalah One Group Pretest Posttest Design, dimana hanya ada 1 kelompok subjek saja yaitu kelompok eksperimen. Berdasarkan hasil analisis data melalui uji Paired sample t test diperoleh nilai signifikansi sebesar 0,000 (p < 0,05). Artinya ada perbedaan yang sangat signifikan sebelum dan sesudah pelatihan pendidikan anti korupsi diberikan kepada peserta pelatihan.
Peristiwa Kerusuhan Mei 1998: Sebuah Gambaran Pengampunan Para Korban
Authors: Himawan Eunike
Published: April 2024

Walau telah berlalu lebih dari dua dekade, peristiwa kerusuhan Mei 1998 meninggalkan trauma dan ketakutan pada para korbannya hingga saat ini. Salah satu konsekuensinya ialah perubahan pandangan dan perilaku etnis Tionghoa dalam berelasi dengan etnis Pribumi. Berdasarkan penelitian-penelitian sebelumnya, ditemukan bahwa pengampunan dapat meningkatkan kecenderungan prososial individu serta mampu menanggulangi trauma, khususnya pada kasus trauma kekerasan rasial. Oleh karena itu, penelitian ini dilakukan untuk mengetahui gambaran pengampunan pada para korban langsung kerusuhan Mei 1998, mengingat pentingnya relasi yang baik antar etnis di negara Indonesia yang memiliki beragam etnis. Penelitian ini menggunakan pendekatan fenomenologi dengan analisa tematik, dengan metode pengumpulan data berupa wawancara terhadap tiga orang partisipan yang merupakan korban pada kerusuhan Mei 1998. Data yang didapat pada wawancara lalu diolah dengan menggunakan metode analisa tematik. Dari hasil penelitian, ditemukan bahwa ketiga partisipan memiliki tekad untuk mengampuni para pelaku dan tidak menyalahkan etnis Pribumi atas kerusuhan yang terjadi, meskipun masih terdapat perubahan perasaan dan perilaku dari etnis Tionghoa terhadap etnis Pribumi akibat peristiwa kerusuhan Mei 1998.
Kontribusi Strength Based Parenting dan Academic Self-Efficacy terhadap Engagement pada Siswa SD Mutiara Harapan Pangkalan Kerinci Riau
Authors: Batubara Ellen Ester , Rohinsa Meilani , Setiawan Tery
Published: April 2024

Penelitian ini bertujuan untuk menginvestigasi kontribusi Strength-Based Parenting dan Academic Self-Efficacy terhadap tingkat engagement (keterlibatan) pada siswa SD Mutiara Harapan Pangkalan Kerinci Riau. Strength-Based Parenting merupakan pendekatan dalam pengasuhan yang memfokuskan pada mengembangkan kekuatan dan potensi anak, sedangkan Academic Self-Efficacy merujuk pada keyakinan individu terhadap kemampuannya dalam menghadapi tugas akademik. Penelitian ini menggunakan pendekatan kuantitatif dengan melibatkan 102 siswa SD Mutiara Harapan sebagai partisipan penelitian. Data diperoleh melalui kuesioner yang mengukur tingkat Strength-Based Parenting, Academic Self-Efficacy, dan engagement pada siswa. Analisis data dilakukan menggunakan teknik regresi untuk menguji hubungan antara variabel-variabel yang diteliti. Hasil penelitian menunjukkan bahwa Strength-Based Parenting dan Academic Self-Efficacy secara signifikan berkontribusi terhadap tingkat engagement pada siswa SD Mutiara Harapan. Semakin tinggi tingkat Strength-Based Parenting yang diterima oleh siswa dan semakin tinggi Academic Self-Efficacy yang dimiliki siswa, maka tingkat engagement siswa cenderung meningkat. Penelitian ini memberikan kontribusi penting dalam pemahaman tentang faktor-faktor yang berpengaruh terhadap engagement pada siswa SD, terutama dalam konteks penggunaan pendekatan Strength-Based Parenting dan pengembangan Academic Self-Efficacy. Hasil penelitian ini dapat memberikan panduan praktis bagi orang tua dan pendidik dalam memperkuat engagement siswa melalui pendekatan pengasuhan yang positif dan pembangunan keyakinan diri akademik.
Effects of Whole-body Electromyostimulation on knee pain and physical function in adults with symptomatic knee osteoarthritis: a randomized controlled trial
Authors: Kast Stephanie , Kemmler Wolfgang , Römer Frank W. , Kohl Matthias , Culvenor Adam G. , Mobasheri Ali , Uder Michael , von Stengel Simon
Published: April 2024

In a randomized, controlled study, whole-body electromyostimulation (WB-EMS) was investigated as a promising alternative to conventional strength training for the treatment of knee osteoarthritis (OA). 72 overweight participants with symptomatic knee OA were randomly assigned to WB-EMS (n = 36) or a usual care control group (CG, n = 36). For seven months, the WB-EMS group received three times per fortnight a WB-EMS training, while the CG was prescribed 6x physiotherapeutic treatments. The primary outcome, change in the pain subscale of the Knee injury and Osteoarthritis Outcome Score (KOOS), significantly improved in favour of the WB-EMS group, with a mean increase of 16.7 points versus 7.0 points in the CG (absolute difference between groups 9.0 points, 95%CI 2.9 to 15.1, p = 0.004). Secondary outcomes, including the other KOOS subscales (symptoms, function in daily living, function in sports/recreational activities and quality of life), 7-day pain diary, isometric muscle strength and lower limb function (30s sit-to-stand test), were also in favour of WB-EMS. With few dropouts and no reported adverse events, WB-EMS had a participation rate of 88% ± 10%. Overall, WB-EMS was found to be effective in relieving knee pain symptoms and improving physical function in individuals with symptomatic knee OA compared to usual care treatment.
MicroRNA-532-3p modulates colorectal cancer cell proliferation and invasion via suppression of FOXM1
Authors: Mahajan Ketakee , Pothuraju Ramesh , Das Ani , Nair Asha
Published: April 2024

Forkhead-box M1 (FOXM1) is a proliferation-associated transcription factor, overexpressed in almost all the cancers. Naturally, the mechanisms of FOXM1 regulation have been under investigation. Previously, we showed that FOXM1 binds to promoters of certain microRNAs. Database mining led to several microRNAs that might interact with FOXM1 3’UTR. The interactions between shortlisted microRNAs and FOXM1 3’UTR was quantitated by dual luciferase reporter assay. MicroRNA-532-3p interacted with 3’UTR of FOXM1 mRNA transcript most efficiently. MicroRNA-532-3p was ectopically overexpressed in colorectal cancer cell lines, leading to reduced transcript and protein levels of FOXM1 and cyclin B1, a direct transcriptional target of FOXM1. Flow cytometry analysis revealed an unaltered cell cycle. A clonogenic assay was conducted that revealed a decline in the ability of cells to form colonies. Additionally, wound healing assay and matrigel invasion assays were carried out. Significant reduction in migratory and invading cell numbers were observed, which were reinforced at molecular levels by the altered transcript and protein levels of the conventional EMT markers E-cadherin and vimentin. Overall, this study identifies the interaction between microRNA-532-3p and FOXM1 3’UTR, leading to reduced protein levels. Ectopic expression of miR-532-3p leads to suppression in cellular proliferation, migration and invasion in CRC cells.
Predicting Water Pipe Failures with Graph Neural Networks: Integrating Coupled Road and Pipeline Features
Authors: Hu Qunfang , Zhang Yu , Liu Wen , He Lei , Che Delu , Su Zhan
Published: April 2024

The reliability of urban water distribution networks (WDNs) is critical for public health and safety. This study presents a novel approach to predicting WDN failures by leveraging Graph Neural Networks (GNNs) and incorporating coupled features of road and water networks, with an emphasis on traffic-related characteristics. Our framework employs Graph Convolutional Networks (GCN), Graph Attention Networks (GAT), and GraphSAGE to capture the complex spatial dependencies and interactions between road infrastructure and water pipelines. We evaluate the performance of these models using a dataset from a Chinese city, focusing on metrics such as Area Under the Curve (AUC), accuracy, and recall. Our results indicate that GraphSAGE outperforms other models, demonstrating its effectiveness in leveraging neighborhood information for failure prediction. The analysis of feature importance highlights the significance of traffic-related attributes, such as the distance of pipelines from the center of intersections, road grades, and the angle of pipelines relative to roads, in addition to traditional factors like pipeline length, diameter, and age. By integrating these coupled features, our study offers a more accurate and comprehensive understanding of failure risks, providing valuable insights for proactive maintenance and management of urban WDNs.
Estrogen-dependent TRX2 activation reverts oxidative stress and metabolic dysfunction associated to steatotic disease
Authors: Morandi Andrea , Smiriglia Alfredo , Lorito Nicla , Bacci Marina , Subbiani Angela , Bonechi Francesca , Comito Giuseppina , Kowalik Marta Anna , Perra Andrea
Published: April 2024

Metabolic disfunction-associated steatotic liver disease (MASLD) encompasses a plethora of hepatic disorders ranging from steatosis to steatohepatitis with the worst clinical outcome represented by cirrhosis, liver failure, and hepatocellular carcinoma. According to the lower MASLD prevalence reported in pre-menopausal women compared to men, we identified a potential protective role of estrogens in counteracting the oxidative stress during disease induction and progression. We have used preclinical relevant in vitro models [i.e., immortalized cells and hepatocyte-like cells (HLC) derived from human embryonic stem cells (hESC)], exposed to sodium lactate, sodium pyruvate, and octanoic acid (LPO) to induce hepatic steatosis. This established practice of MASLD induction resulted in lipid droplet (LD) accumulation and increased mitochondrial and cytosolic reactive oxygen species (ROS) levels, paralleled by the reduction of several markers of hepatocyte function and differentiation. Here we found that estrogen replacement reduced ROS levels and LD content through the upregulation of mitochondrial thioredoxin 2 (TRX2), an antioxidant system that is under the control of the estrogen receptor alpha (hereafter referred as ER). Last, disrupting the TRX2 system using auranofin was sufficient to revert the scavenging effects exerted by estrogens, thus identifying a potential mechanism that could prevent or delay the progression of the disease.
In Vitro Study of Phycocyanin Effect on Cellular Defence Mechanisms and IL-17 Gene Expression in Stimulated Human Peripheral Blood Mononuclear Cells
Authors: Esmaeili Fatemeh , Esmaeili Behnaz , Emamshoushtari Mir Mehrshad , Helchi Salar , Pourmand Mahmoodreza , pajoumshariati Farshid
Published: April 2024

Chronic inflammatory diseases are typically characterized by persistent immune responses triggered by genetic factors and the release of inflammatory markers. While current pharmacological treatments, such as steroids and non-steroidal anti-inflammatory drugs, may be effective, they have limitations and can cause side effects. This study examines the effects of phycocyanin, an antioxidant pigment extracted from Spirulina platensis, in both encapsulated (ENPC) and non-encapsulated (PC) forms on the antioxidant activity of catalase, superoxide dismutase 1 (SOD1), and superoxide dismutase 2 (SOD2), along with the expression of the interleukin-17 (IL-17) inflammatory gene in peripheral blood mononuclear cells (PBMCs) under phytohemagglutinin (PHA)-induced inflammatory conditions. The MTT assay demonstrated that phycocyanin is not toxic to PBMCs, as cell viability exceeded 96% after 48 hours. The results indicated that ENPC and PC increased the enzyme expressions of catalase, SOD, but decreased the expression of IL-17 gene. Multi-groups analysis of genes expression using Kruskal-Wallis test revealed that no significant differences in catalase, SOD1, SOD2 and IL-17 gene expressions among PBMCs treated with different concentrations of C-PC (200 and 1000 µg.mL− 1) and in ENPC and PC forms. However, Mann-Whitney non-parametric test for pairwise gene expression analysis, revealing significant differences. Catalase expression showed noteworthy distinctions between unstimulated and PHA-stimulated cells in the presence of PC at 200 µg.mL− 1 and 1000 µg.mL− 1. Additionally, a significant contrast in SOD1 gene expression emerged between unstimulated and PHA-stimulated cells at PC 200 µg.mL− 1 Moreover, PHA-stimulated cells with ENPC at 1000 µg.mL− 1 exhibited a substantial decrease in IL-17 gene expression.
Research on calibration technique of camera coordinate system for binocular stereo vision system base on least-square method
Authors: li shengqian , zhang xiaofan
Published: April 2024

Index of the application for a binocular visual system. According to the measurement results of a binocular vision system is mainly used relative measuring accuracy to verify, but that can't be achieved to verify by artificial specific measurement, and also this work is measured in camera coordinate system, because of the camera's optical center couldn't be located, for the problem that where is the specific camera coordinate system, that can't give a specific location, but only giving the definition of a concept. In order to solve these problems, a calibration transformation method of the camera coordinate system based on the least square method is proposed, this method mainly through calibration of the camera coordinate system transforms to a presetting specific existence and positioning coordinate system. Meanwhile, by making the optical axis through the geometric center of a camera lens, then the accuracy of the binocular vision measurement system can be verified in the coordinate system. Finally, the result of the experiment shows that the proposed method is correct and effective to calibrate camera coordinate system, the accuracy of calibration is more higher, and the requiring equipment for verification is very simple.
Prognostic Risk Factor for Early Outcomes of Patients with Myelomeningocele: A Prospective Study
Authors: Alavi Seyed Ahmad Naseri , Rezkhah Amir , Majdi Alireza , Habibi Mohammad Amin , Bagheri Mohammad Mehdi , Jafarzadeh Fateme , Kobets Andrew J.
Published: April 2024

Introduction:
Myelomeningocele (MMC) is a prevalent form of neural tube defect. Despite advancements in treatment, MMC still poses significant health risks, including complications leading to chronic disability and mortality. Identifying prognostic risk factors for early outcomes is crucial for tailored intervention strategies.
Methods
This prospective study involved newborns and infants diagnosed with MMC who underwent surgery between 2020 and 2023 at Urmia University of Medical Sciences. Demographic data and surgical outcomes were collected, and participants were followed up for six months. Statistical analyses were conducted using descriptive statistics, Chi-Square, and independent t-test.
Results
The study included 29 MMC cases, with an incidence rate of 1.4 per 10,000 live births. Lesions were predominantly located in the lumbar spine. Although mortality rates appeared to increase with ascending lesion sites, this trend was not statistically significant. Short-term outcomes revealed high morbidity and mortality rates, with neurological deficits being the most prevalent complication. Multivariable analysis identified head circumference as a significant predictor of adverse outcomes (IRR = 1.37, 95% CI = 1.02 to 1.86, p = 0.04). Furthermore, an increase in birth weight was associated with a reduction in the incidence of requiring a ventriculoperitoneal shunt (IRR = 0.99, 95% CI = 0.998 to 0.999, p = 0.02)
Conclusion
This prospective study highlights prognostic risk factors for early outcomes in MMC patients, emphasizing the need for personalized intervention strategies. By addressing modifiable risk factors and implementing targeted interventions, healthcare providers can strive to improve outcomes and enhance the quality of life for MMC patients.
Increasing ambient temperature disrupts sleep and impairs cognitive function among Older Adults
Authors: Boateng Godfred O. , Dusing Gabriel J. , Shafiquzzaman Shaira , Lartey Stella T. , Agbe Eyram , Quansah Reginald , Okoye Dozie
Published: April 2024

Increases in ambient temperature have been associated with deleterious consequences for socially disadvantaged populations. However, there is limited research on the associated mental health effects. Thus, this study examined the direct and indirect effects of high temperatures on sleep quality and cognitive function among older adults. Using combined data from the WHO Ghana Study on Global Ageing and Adult Health with temperature measurements derived from the Climatic Research Unit gridded Time Series and structural equation models, we examined the direct and indirect relationship between increasing mean temperatures, sleep difficulties, and cognitive impairment while adjusting for appropriate covariates. Increases in mean temperature change were associated with an increase in the severity of sleep difficulties and a decrease in cognitive function. The effect of temperature significantly increased sleep difficulties for females and older adults (65+). Our study shows that a reduction in temperature will improve sleep quality and enhance cognitive function.
Correlation between lung microecology and immunity in patients with anti-MDA5 antibody-positive dermatomyositis combined with interstitial lung disease: protocol for a prospective, multicentre cohort study
Authors: Liu Shuzi , Duan Zhimei , Wang Kaifei , luo Gui , Ji Xiaojian , Hu Ye , Fu Han , Liu Miao , Zhu Jian , Xie Fei
Published: April 2024

Introduction
Anti-melanoma differentiation-associated gene 5 antibody-positive dermatomyositis (anti-MDA5+ DM) may be associated with interstitial lung disease (ILD), particularly rapidly progressive interstitial lung disease (RP-ILD). It leads to a poor prognosis and mortality rate of approximately 40%–90%. Patients with ILD or RP-ILD are always infected with various pathogens in the lungs. However, the aetiology and pathogenesis of the susceptibility of patients with anti-MDA5+ DM to ILD or RP-ILD remain largely unknown. Multiple studies have confirmed the existence of pulmonary microecology in respiratory diseases related to host immune response. However, the relationship and mechanism underlying the immune response and pulmonary infection in patients with anti-MDA5+ DM have not been reported. Therefore, this study aimed to explore the mechanism of ILD/RP-ILD susceptibility in patients with anti-MDA5+ DM through the relationship between the pulmonary microbiome, host immune response, and the presence or absence of concurrent RP-ILD.
Methods /design
We will enrol 50 patients with anti-MDA5+ DM from multiple medical centres, who will be divided into three groups: anti-MDA5+ DM with RP-ILD, anti-MDA5+ DM with non-RP-ILD, and anti-MDA5+ DM without ILD. Patients will be followed up for 6 months, with three clinical samples and data collected. We will identify pathogenic microorganisms and host genome metagenomics through next-generation sequencing (mNGS) and metagenomics third-generation sequencing (mTGS), and analyse whether identical or similar gene fragments of MDA5 are present in the genes of patients' lung microbiota to explore the possible relationship between pathogen genes and MDA5 antibody production. Additionally, we will analyse the host immune function status, inflammatory response status, and infection stage by immune cell counting, single-cell sequencing, metabolomics, proteomics, and flow cytometry.
Discussion
The study aims to conduct a comprehensive assessment of the host immune function status after infection and explore the relationship between the lung microbiome, host immune function status, and RP-ILD. Finally, we expect that the results of this study will potentially provide an early warning for RP-ILD development in patients with anti-MDA5+ DM and lay the foundation for future differentiated treatments targeting opportunistic pathogens and/or host immune factors.
Trial registration
ClinicalTrials. gov, identifier: NCT06203249. Registered on December 28, 2023.
Fault detection method for flexible DC grid based on current limiting reactance voltage variability
Authors: Zeng Zhihui , Zheng Yingying , Wei Yanfang , Wang Xiaowei , Li Jiayin
Published: April 2024

AbstractFast and reliable identification of DC line faults is the key to the stable operation of flexible DC grids. Based on the boundary element characteristics of DC lines, a fault detection method for flexible DC grids based on current limiting reactance voltage variability is proposed. First, the equivalent model of DC grid when different faults occur is established, and the filtered voltage change rate is used as the protection startup criterion by taking advantage of the rapid change of fault voltage. Secondly, according to the characteristics of voltage change at both ends of the current limiting reactor of the DC line after the fault, the peak factor is used to extract the voltage change characteristics to constitute the internal and external faults criterion. Finally, the ratio of energy values of positive and negative current limiting reactance voltages on the DC line is calculated to constitute the fault pole selection criterion. Simulation results show that the proposed protection scheme can effectively identify internal and external faults and fault poles, and its principle is simple, with low communication requirements, strong resistance to transition resistance, strong anti-interference ability, and can better meet the requirements of DC grid for the protection of the rapidity and selectivity.
Tomografia Computadorizada de Feixe Cônico no Planejamento de Correção Cirúrgica da Linha do Sorriso após Tratamento Ortodôntico. Relato de Caso
Authors: Salzedas Leda Maria Pescinini , Miguel Igor Henrique da Silva , Nuernberg Marta Aparecida Alberton , Takeshita Wilton Mitsunari , Alves Rezende Maria Cristina Rosifini , Kajimoto Natalia de Campos
Published: April 2024

A dimensão das estruturas dentogengivais é importante na saúde periodontal. O aumento de tecido gengival resulta em estética desfavorável do sorriso, e prejuízo à saúde periodontal. A hiperplasia gengival inflamatória é um processo proliferativo não neoplásico, e pode ocorrer devido a fatores irritativos crônicos de baixa intensidade como o biofilme dentário. Ela é uma sequela relativamente comum no tratamento ortodôntico, pois os aparatos ortodônticos dificultam a higienização ocasionando um processo inflamatório e consequentemente a hiperplasia gengival inflamatória. A tomografia computadorizada de feixe cônico (TCFC) realizada com dispositivos para afastamento labial, permite a análise da dimensão e relação das estruturas dentogengivais para o planejamento cirúrgico de correção gengival. O objetivo deste trabalho é relatar um caso de correção cirúrgica de hiperplasia gengival inflamatória após tratamento ortodôntico, com planejamento cirúrgico usando TCFC com afastamento labial (ST-TCFC). Paciente sexo masculino, 23 anos, compareceu ao consultório particular com queixa de desarmonia gengival no arco superior. Relatou ter finalizado o tratamento ortodôntico e realizado raspagem supragengival há 30 dias. No exame intrabucal, constatou-se um aumento gengival do dente 14 ao 24. Com o exame de ST-TCFC, o diagnóstico clínico foi de hiperplasia gengival inflamatória, e o planejamento cirúrgico feito a partir das medidas dentogengivais nas imagens. Realizou-se a técnica de gengivectomia e gengivoplastia para restituir as características anatomofuncionais normais do periodonto de proteção. Conclui-se que a técnica ST-TCFC possibilitou a efetividade diagnóstica e planejamento cirúrgico previsível da correção da linha do sorriso, com resultados estéticos e funcionais mais precisos. É fundamental a orientação da higienização bucal para manutenção dos resultados obtidos.
Comment on the article of L.A. Krichevskiy et al. “Systemic inflammatory response syndrome after on-pump cardiac surgery in emergency coronary artery bypass grafting: a retrospective trial”
Authors: Grigoryev Evgeny V.
Published: April 2024

Comment on the article of L.A. Krichevskiy et al. “Systemic inflammatory response syndrome after on-pump cardiac surgery in emergency coronary artery bypass grafting: a retrospective trial”
Pain intensity profile after a single injection of the peptide analgesic taphalgin in traumatology and orthopedic patients: prospective observational cohort study
Authors: Karelov Aleksei E. , Sorokin A. S. , Gamzeleva O. Y. , Kraevskaya Y. N. , Kellarev M. K. , Orozaliev I. E. , Karelov D. A. , Zabolotskii D. V. , Khmara V. M.
Published: April 2024

INTRODUCTION: Multimodal analgesia is the main management strategy for postoperative pain. One component of this approach is opioid agonists. OBJECTIVE: Assessment of pain intensity profile after a single administration of the new selective µ1-opioid receptor agonist taphalgin in traumatology and orthopedic patients. MATERIALS AND METHODS: This prospective observational program analyzed data from 100 patients whom were prescribed the drug taphalgin for pain relief after traumatological and orthopedic surgery. All patients were treated with 50 mg dexketoprofen when moderate pain appeared after surgery. If the pain reached moderate or high intensity again, 4 mg of taphalgin was administered subcutaneously and then the change in pain intensity at rest and during movement was observed after 15, 30, 45, 60 min, as well as 2 and 4 h, using numerical rating scale (NRS). In this study physicians’ satisfaction by taphalgin was estimated. Satisfaction was assessed using Likert scale, where 1 — very bad, 2 — unsatisfactory, 3 — satisfactory, 4 — good, 5 — excellent. Repeated measures analysis of variance and dependent samples t-test were used for statistical analysis. The critical level of significance for accepting significant differences was set at 0.05. RESULTS: The average value of pain intensity before drug administration at rest was 5.9 ± 0.5 points and pain in movement was 8.4 ± 0.8 points. After just 15 min, significant pain reduction was achieved to 4.9 ± 0.8 and 7.3 ± 1.1 points (p < 0.001), respectively, after 30 min — to 3.6 ± 1.1 and 5.7 ± 1.1 points (p < 0.001), respectively, and after 60 min — to 2.2 ± 0.8 и 4.2 ± 0.8 points (p < 0.001), respectively. Doctor’s satisfaction with treatment showed that a positive assessment was given in 83 % of cases, and complete dissatisfaction was revealed in 1 % of cases. Impotently, no observations of respiratory depression or postoperative nausea and vomiting syndrome have been recorded. CONCLUSIONS: The drug taphalgin is an effective analgesic for the postoperative period in traumatology and orthopedics.
Analysis of the guideline “Perioperative management of patients with coronary artery disease”, “Perioperative management of patients with concomitant pathology of the heart valves” and “Perioperative management of patients with concomitant morbid obesity”: modified Delphi method
Authors: Lakhin R. E. , Dunts Pavel V. , Trembach N. V. , Andreenko A. A. , Bayalieva A. Zh. , Gorokhovsky V. S. , Grigoryev E. V. , Gritsan A. I. , Gruzdev V. E. , Ezhevskaya A. A. , Ershov V. I. , Kitiashvili I. Z. , Kokhno V. N. , Kuzovlev A. N. , Kuligin A. V. , Levit A. L. , Leiderman I. N. , Magomedov M. A. , Myasnikova V. V. , Ovezov A. M. , Orlov Yu. P. , Popugaev K. A. , Potievskaya V. I. , Savvina I. A. , Sitkin S. I. , Spasova A. P. , Fisher V. V. , Khoronenko V. E. , Shen N. P.
Published: April 2024

INTRODUCTION: The development of clinical and methodological recommendations improves the quality of medical care and reduces the risk of complications. OBJECTIVE: To analyze the methodological recommendations “Perioperative management of patients with coronary heart disease”, “Perioperative management of patients with concomitant pathology of the valvular heart apparatus” and “Perioperative management of patients with concomitant morbid obesity” using the modified Delphi method. MATERIALS AND METHODS: A modified Delphi method was used with two rounds of questionnaires to develop a consensus. The agreement of specialists was reached in three stages: the preparatory stage, the discussion stage and the stage of developing a consensus conclusion. RESULTS: When discussing the methodological recommendation “Perioperative management of patients with coronary heart disease”, a consensus was reached on 35 out of 37 provisions and 7 out of 8 criteria for the quality of medical care. The analysis of the methodological recommendation “Perioperative management of patients with concomitant pathology of the valvular heart apparatus” showed that 57 out of 60 provisions, as well as all 13 criteria for the quality of medical care, were agreed upon. The discussion of the methodological recommendations “Perioperative management of patients with concomitant morbid obesity” showed that 22 of the 23 provisions of the recommendation and all 5 quality criteria were agreed upon. CONCLUSIONS: The results of the Delphic examination, obtained as a result of a detailed analysis by independent experts, will be useful for the co-authors of the discussed methodological recommendations before the planned revision.
Family, partnership, life satisfaction and well-being, emotional burnout and depression of employees of anesthesiology and intensive care departments: a multicenter anonymous observational trial
Authors: Sinbukhova Elena V. , Protsenko D. N. , Lubnin A. Yu. , Shchegolev A. V.
Published: April 2024

INTRODUCTION: Currently, emotional burnout and its predictors are insufficiently studied among the staff of the departments of anesthesiology and intensive care. At the same time, burnout is associated with a decrease in the quality of medical care, patient safety, as well as the quality of life of the doctors themselves. An anonymous study was conducted in hospitals and clinics in Russia. OBJECTIVE: To assess the level of life satisfaction, well-being, emotional burnout and depression of the staff of the departments of anesthesiology — intensive care. MATERIALS AND METHODS: Maslach Burnout Inventory, Projective psychological technique “unfinished sentences” (based on Sacks sentence completion test) — tested by G.G. Rumyantsev, Beck Hopelessness Inventory, Beck Depression Inventory, Satisfaction with Life Scale (E. Diener, R.A. Emmons, R.J. Larsen, S. Griffin). Brief Inventory of Thriving (BIT) (R. Su, L. Tay, E. Diener). RESULTS: The average level of life satisfaction of anesthesiologists was 14.7 points, which corresponds to the level of dissatisfaction, resuscitators and nurses had 19 points and 17.7 points, respectively — below the average level. Average and high levels of burnout in all three subscales had: 32.77 % of anesthesiologists, 52.26 % of resuscitators, 33.7 % of nurses. Depression symptoms varying degrees was detected in 83.62 % of anesthesiologists, 80 % of resuscitators and 51.7 % of nurses. CONCLUSIONS: It is necessary today not only to identify the first symptoms of burnout, but also to assess the level of satisfaction with the life and work of doctors, because they can directly affect the quality of medical care provided. It is probably that the even greater interest in the problem of doctor’s burnout and greater number of publications about this problem will become the element that encourages medical workers to seek psychological help.
Criminal cases against anesthesiologists and intensivists in Russia for 2019–2022: a retrospective observational study
Authors: Gorbachev Vladimir I. , Utkin N. N. , Netesin E. S. , Gorbachev S. V. , Malygina A. V. , Lavrentiev A. M. , Urbazaev A. A.
Published: April 2024

INTRODUCTION: The number of criminal cases brought against doctors — anesthesiologists and resuscitators in the Russian Federation is not decreasing. However, a detailed analysis has not been carried out in recent years, and this was primarily due to the pandemic of the new coronavirus infection COVID-19 and the restrictions that were associated with it. OBJECTIVE: To analyze criminal cases against anesthesiologists and resuscitators initiated under various articles of the Criminal Code of the Russian Federation over the past four years, from 2019 to 2022. MATERIALS AND METHODS: The search for criminal cases was carried out in the following electronic databases: “Court decisions of the Russian Federation” and the State Automated System of the Russian Federation “Justice”. Based on the search results, 66 criminal cases against anesthesiologists and resuscitators were considered. RESULTS: The main articles of the Criminal Code of the Russian Federation were identified, under which anesthesiologists and resuscitators are most often held accountable. The gender and territorial distribution of criminal cases by region of the Russian Federation is presented. The most significant and frequently committed defects in the provision of medical care have been identified. Examples of the most complex criminal cases are given. CONCLUSIONS: It seems that the number of criminal cases against anesthesiologists and resuscitators has decreased slightly after 2019, however, we believe that this is due to the pandemic of the new coronavirus infection, and for this reason many court cases are still under investigation and have not been completed on time.
Anaphylactic shock (2nd revision). Clinical guidelines of Russian Association of Allergists and Clinical Immunologists and the All-Russian Public Organization “Federation of Anesthesiologists and Reanimatologists”
Authors: Ilyina N. I. , Zabolotskikh Igor B. , Astafieva N. G. , Bayalieva A. Zh. , Kulikov A. V. , Latysheva T. V. , Lebedinskii K. M. , Musaeva T. S. , Myasnikova T. N. , Pampura A. N. , Fassakhov R. S. , Shifman E. M.
Published: April 2024

Anaphylaxis is a severe life-threatening emergency that requires prompt recognition, prompt respond and of lifesaving therapy. Therefore, anaphylaxis can develop both in a medical institution and outside it (outpatient), and physicians of any specialties should be ready to treat this condition. In this regard, clinical guidelines for anaphylaxis have been developed in Russia. Previous version of recommendations were approved by the Russian Association of Allergologists and Clinical Immunologists and the Federation of Anesthesiologists and Resuscitators, approved at a meeting of the Scientific and Practical Council of the Ministry of Health of the Russian Federation (protocol No. 2020 No. 743/12).
The second edition important clarifications have been made in etiology, epidemiology, classification, clinical picture, diagnosis, treatment and prevention of anaphylaxis and clear some definitions for prompt response, and also management of patients with concomitant diseases. Clinical guidelines of anaphylaxis are intended for practitioners of all specialties, students and teachers of medical universities, residents, graduate students.
Shinjima: Vulnerability, Resilience and Island Fluidity
Authors: Johnson Henry , Kuwahara Sueo
Published: April 2024

Shinjima (‘New Island’), a relatively recent volcanic island in south-west Japan, has undergone cycles of settlement, depopulation and re-settlement, mirroring similar circumstances encountered by many small island cultures in Japan. Throughout its history, and in the vicinity of ongoing volcanic activity, the island has experienced periods of vulnerability and resilience, marked by fluctuations in its population and leading to shifts in the island’s identity. Together, these phenomena are explained using the metaphor of fluidity, emphasising continuing changes in Shinjima’s environmental, social and cultural existence. As discussed in this article, in today’s context, Shinjima has emerged as an example of small island revitalisation that is distinct to its locale, embodying a multifaceted identity centred on cultural rejuvenation, environmental activism and micro-tourism. Positioning this study within the field of Island Studies, the article foregrounds Shinjima by documenting its dynamic history and emphasising recent transformations that have augmented and revitalised the small island’s cultural narrative in the contemporary era.
Fantastik Roman ve Babil Melikesi Romanında Fantastik Unsurlar
Authors: Karaca Yalçın Hünkar
Published: April 2024

Romanın başlı başına bir tür olarak kabul edilmesi çeşitli aşamalar geçildikten sonra olmuştur. Batı’da romanın, romans ve pikarolardan farklı bir anlatı olduğunu ispat etmek isteyen yazarlar, romanın “gerçeği” anlattığını vurgulamaya ve “fantastik” ürünlerle romanın sınırlarını çizmeye çalışmışlardır. Edebiyatta fantastik, masallardan itibaren vardır ancak masalın sadece hayal ürünü olduğunun ön kabulü fantastik roman ile aralarındaki farkı oluşturmaktadır. Başlangıçta realist romanlar, romantik dilin önüne geçmiş bunu natüralist romanlar izlemiştir. Ancak modernizm ve postmodernizim etkisi ile romanın dili daha da esnek bir hâl alarak “hayal” olana yani fantastik olana daha fazla karşı duramamıştır. Türk edebiyatında da Batı’da olduğu gibi “gerçeği” anlatmak isteyen Tanzimat romancıları fantastiğe karşı durmuşlardır. Gelenekselden beslenen dilin fantastiğe yatkınlığı yazarların ondan beslenmelerini de engelleyememiştir. Böylece Türk edebiyatında ötelenmiş bir tür olan fantastik roman, sessiz bir şekilde ilerleyişini sürdürmüştür. Ahmet Midhat Efendi, Giritli Aziz Efendi, Hüseyin Rahmi Gürpınar gibi yazarlar bu türün ilk örneklerini vermişlerdir. XIX. yüzyılın başında kaleme alınan Babil Melikesi romanı da fantastik özellikler bakımından oldukça dikkate değer bir romandır ve ilk fantastik romanlar arasında olması açısından önemlidir. Bu çalışmada Selami İzzet Sedes’in kaleme aldığı Babil Melikesi romanında fantastik unsurlar incelenecek ve fantastik romanın Türk edebiyatındaki yeri ele alınacaktır.
17- 18. Yüzyıl Avrupa Resim Sanatında Türk İmgesi Olarak Kahve
Authors: Özkaymak Bilge , Baş Ali
Published: April 2024

Çalışmamızın konusunu 17- 18. yüzyılda, Avrupa’daki Türk hayranlığının bir parçası olarak Avrupalıların hayatında kendine yer edinen kahve kavramının Avrupa resim sanatına yansıması oluşturmaktadır. Türk ve Avrupa toplumları politik, ekonomik, sosyal ilişkilerinden dolayı birbirlerinden etkilenmişler, bu da kaçınılmaz olarak sanatlarına yansımıştır. Bu yansıyış, sanatın her alanında kendini gösterdiği gibi görsellikten beslenen resim sanatında da geniş olarak hissedilmiştir. Genel olarak, 18. yüzyıldan sonra Türk sanatında Avrupa etkileri görülmeye başlanmasına rağmen 17. ve 18. yüzyıllarda bu etki, Türk kültürünün Avrupa sanatına etkisi olarak görülmüştür. Çalışmamızda ele aldığımız kahve kavramının kökeninin Türk toprakları olmamasına rağmen Avrupa’ya Türkler aracılığıyla girmesi, kahvenin Avrupalılarca bir Türk imgesi olarak görülmesini sağlamıştır. Bu nedenle, 17- 18. yüzyıl Avrupa resimlerinde de kahve kavramı hep ‘Türk’ ile ilişkilendirilerek seyirciye sunulmuştur. Resim sanatının kurgusal ifadelere sahip olduğu gibi gündelik yaşamdaki bazı kesitlerden de ilham aldığı açıktır. Dolayısıyla, Avrupalıların hayatlarına yeni katılan bu kavramı tek başına hayatlarına ve resimlerine aktarmaları imkânsız olup kahve denilince akla gelen her türlü kavramı da kahve ile birlikte kabul ettikleri söylenebilir. Bu da bu dönemde ortaya çıkan Türköri akımının Avrupa'da geniş alanlara yayılmasını sağlamıştır. Çalışmada ele alınan örnekler, 17- 18. yüzyıl kapsamında Türköri başlığı altında ele alınabilecek örneklerdir. O dönemde pek çok örnekte resimlerin herhangi bir yerine yerleştirilmiş kahve imgesi bulunmasına rağmen çalışmadaki örnekler doğrudan Türk’e gönderme yapan, eserlerin adında Türk ismi geçen ya da eserlerde Türk kıyafeti giyen figürlerin bulunduğu veya figürlerin Türk’ü anımsatan mekânlarda tasvir edildiği örneklerden seçilmişlerdir.