bluuebunny/crossref_metadata_2025 huggingface dataset:
Amyotrophic Lateral Sclerosis Modifiers inDrosophilaReveal the Phospholipase D Pathway as a Potential Therapeutic Target
Authors: Kankel Mark W , Sen Anindya , Lu Lei , Theodorou Marina , Dimlich Douglas N , McCampbell Alexander , Henderson Christopher E , Shneider Neil A , Artavanis-Tsakonas Spyros
Published: April 2020

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder lacking effective treatments. ALS pathology is linked to mutations in several different genes indicating...

Amyotrophic lateral sclerosis (ALS), commonly known as Lou Gehrig’s disease, is a devastating neurodegenerative disorder lacking effective treatments. ALS pathology is linked to mutations in >20 different genes indicating a complex underlying genetic architecture that is effectively unknown. Here, in an attempt to identify genes and pathways for potential therapeutic intervention and explore the genetic circuitry underlying Drosophila models of ALS, we carry out two independent genome-wide screens for modifiers of degenerative phenotypes associated with the expression of transgenic constructs carrying familial ALS-causing alleles of FUS (hFUSR521C) and TDP-43 (hTDP-43M337V). We uncover a complex array of genes affecting either or both of the two strains, and investigate their activities in additional ALS models. Our studies indicate the pathway that governs phospholipase D activity as a major modifier of ALS-related phenotypes, a notion supported by data we generated in mice and others collected in humans.
Overcoming the Ideology of Extremism and Terrorism Among Today’s Youth
Authors: Oganesyan Sergey S.
Published: April 2020

This paper attempts to substantiate the need to align the legal consciousness of the world community of nations with the norms of international law and existing legislation in each specific country. In tandem with this, this paper also emphasizes the need to develop scientific thinking and a scientific approach to solving social problems of being in teenagers and young people. Currently, the surge in extremism and terrorism among adolescents and young people is associated not only with the most powerful global integration and migration processes, but also with the transition of humanity from one civilizational mentality to another. In particular, it is connected with the mental transition from religious-based civilizations of paganism and monotheism to the scientific worldview, which is the result of the intellectual activity of people who consider themselves to be superior to religion. As previous norms of behavior become obsolete and irrevocably disappear, and new ones form, the role of all state and public organizations in personality development increases immeasurably, guided by the values of the scientific world and tolerance of diverse opinions, attitudes, behavior and organization of life and leisure. It is no less important that such development strictly follow the laws of each country. The latter applies in particular to migrants whose ideological and legal positions are often anchored in religion which may differ substantively from that of the host country leading to problems in integration.
Representaciones sociales del cáncer de mama: una comparación de mujeres con diagnóstico reciente y mujeres sanas
Authors: Chávez-Díaz Alexis , Gómez-González Maria del Pila , Torres-López Teresa Margarita
Published: April 2020

Objetivo. Identificar las representaciones sociales (RS) del cáncer de mama en mujeres con diagnóstico y mujeres sanas o libres de enfermedad (MLE), Guadalajara-Jalisco, 2016. Método. Se aplicó la técnica asociativa de listados libres y cuestionario de pares a 40 mujeres; para conocer la estructura de las RS se hizo análisis de contenido temático y estructural de la RS. Resultados. Los hallazgos muestran que las mujeres diagnosticadas tienen mayor conciencia sobre la importancia de prevención y detección oportuna. MLE otorgaron mayor importancia a aspectos negativos como miedo y muerte. La RS sobre la enfermedad se construye a través de las vivencias, ya sea propia con el diagnóstico o a través de experiencias de una persona cercana o conocimientos sociales.
Matemática em ação: reflexões do experimento “ateliê de matemática” no ensino fundamental
Authors: Silva Rodrigo Sychocki da , Campos Leandro de Andrades
Published: April 2020

O artigo é um recorte de uma pesquisa de mestrado em Ensino de Matemática que consistiu no desenvolvimento de uma sequência de atividades de caráter interdisciplinar, a partir de estruturação teórica e metodológica, seguida da experimentação em uma turma dos anos finais do Ensino Fundamental de uma escola municipal situada no Rio Grande do Sul. O objetivo principal da pesquisa foi analisar como os estudantes, a partir de diálogos e comunicações, produziam e argumentavam sobre matemática. Utilizaram-se como fundamentação teórica para as análises e reflexões sobre a prática as ideias de Jean Piaget e Lev Vygotsky. A pesquisa de cunho qualitativo e definida na modalidade de pesquisa-ação fez com que o professor-pesquisador envolvido nas atividades observasse, analisasse e refletisse sobre suas ações e também sobre as produções matemáticas dos estudantes. A título de conclusão para a pesquisa destaca-se que o trabalho coletivo na sala de aula além de oportunizar momentos de aprendizagem valoriza o desenvolvimento da postura autônoma dos estudantes diante de situações que exija reflexão a respeito da matemática utilizada.
Pesquisas sobre o Estado da Arte no Ensino de Ciências e Biologia: um estudo a partir de teses e dissertações
Authors: Flores Silva Roberta , Modrzejewski Zucolotto Andréia
Published: April 2020

Nesse artigo é apresentado um levantamento de teses e dissertações que realizaram pesquisa do tipo Estado da Arte, voltados ao ensino de Ciências e Biologia, com o intuito de mapear os assuntos que foram abordados em tais estudos e, por conseguinte, verificar se a temática “atividades práticas” está entre eles. Foram 64 trabalhos que abordaram os mais diferentes assuntos, sendo a maioria voltados a questões de ensino-aprendizagem. Não foi encontrado nenhuma tese ou dissertação que abordasse a temática “atividades práticas” utilizando essa expressão. Contudo, foram encontrados estudos que discutiram modalidades de atividades práticas como as atividades lúdicas e as experimentais. Nessa perspectiva, salienta-se a necessidade de estudos que abordem a temática de uma forma mais aprofundada e ampla, levando-se em conta não somente uma, mas as várias modalidades desse tipo de atividade para as áreas de Ciências e Biologia, visto que a prática nas respectivas áreas, é de suma importância para a compreensão dos conteúdos e para o desenvolvimento de habilidades por parte dos alunos nas aulas.
The Implementation and Results of the Use of Social Media in the Republic of Georgia
Authors: Griffin George , Noniashvili Maia , Batiashvili Mikheil
Published: April 2020

The Republic of Georgia has begun a transition from old world economics to integrating social media and the Internet to provide a global presence for the country. Research shows that the Georgian people have significantly embraced social media as a means for conducting business and connecting with many countries on a global basis. Internet subscribers have continually increased in numbers; thus the numbers of social media participants has also increased. This paper addresses the history of Georgia, the current status of social media in Georgia, and the future for social media as it permeates the Georgian population. In order to maintain a robust economic recovery, Georgia citizens and businesses must continue to conduct business through social media pathways that will keep Georgia in the global market.
The Business Women’s Association of Uzbekistan: A qualitative study of the emergence and potential influence of women’s leadership in Central Asia
Authors: Millier Kimberly , Bellamy Patty-Jo
Published: April 2020

This phenomenological study used the first five steps of a modified van Kaam method by Moustakas in conjunction with semi-structured interviews to explore the lived experiences of a sample of front line leaders of the Business Women’s Association of Uzbekistan (Tadbikor Ayol) that operates in an environment hostile to women in general and to businesswomen specifically. The association, founded in 1991 continues to develop and mentor the women entrepreneurs of Uzbekistan. Discovering the factors that influence the viability and sustainability of the BWA as it continues to operate in a challenging cultural and political environment and the applicability of the factors to Central Asia was the focus of this study. The results of the research identified five themes: 1) leadership style; 2) seminars and skill building activities; 3) peer and family relationships; 4) financial support; and 5) government relations.
An analysis of Central America and Eastern Europe Revealed Comparative Advantages
Authors: Gutierrez Mauricio Garita , Godinez Jose
Published: April 2020

The present study applies the revealed comparative advantages through the Balassa Index to determine the comparative advantages, disadvantages, and intra-product commerce tendencies between Central America and Eastern Europe with the purpose of determining the possibility of a free trade agreement for Central America. The approach of the study is through the connection between the European Economic Union and the Central American Common market, which shares a common background and relates them to research of Bela Balassa (1965) to determine how commerce between Central America and Eastern Europe has performed and the possibilities of growth that this commerce has through a free trade agreement. The study demonstrates the importance of analyzing competitive advantages. This paper presents the difference in competitive advantage between Eastern Europe and Central American establishing the benefits when negotiating a free trade agreement between both economic blocks. Therefore, analyzing and negotiating between products of competitive advantages may lead to a more sustainable economic growth.
Reconstruction of a wetting-induced shallow landslide in Shillong, India
Authors: Das Partha , Bharat Tadikonda Venkata
Published: April 2020

The hill slopes of the north eastern region of India often encounters shallow landslide during the rainy season. Forensic study of a failed hill-slope in such areas is useful in improving the understanding of the failure mechanism. An incessant rainfall triggered a shallow landslide in the Umshing Mawkynroh locality of Shillong in North-east India during the rainy season of 2019. In this work, a forensic investigation was carried out by performing a coupled unsteady-state seepage and stability modelling to reconstruct the actual failure surface. The recorded rainfall data, slope geology, and soil hydraulic properties of the compacted laterite soil were used to back-estimate accurately the in situ failure surface. The underlying mechanism responsible for the shallow landslide during the rainfall infiltration was identified from the numerical modelling. The combined effect of wetting front advancement in the initial partial saturation zone and the rise of the perched groundwater table was found to be the mechanism responsible for the failure.
Renal Involvement and Early Prognosis in Patients with COVID-19 Pneumonia
Authors: Pei Guangchang , Zhang Zhiguo , Peng Jing , Liu Liu , Zhang Chunxiu , Yu Chong , Ma Zufu , Huang Yi , Liu Wei , Yao Ying , Zeng Rui , Xu Gang
Published: April 2020

Significance Statement

Some cases of COVID-19 pneumonia have presented with kidney injury, and autopsy findings for patients with COVID-19 have revealed renal involvement. In this retrospective, single-center study of Chinese patients with COVID-19 pneumonia, 251 of 333 patients (75.4%) presented with renal complications, including proteinuria, hematuria, and AKI. After the median duration of 12 days of follow-up, nearly half of patients with AKI recovered from AKI within 3 weeks of onset of infection. However, patients with renal involvement had higher overall mortality (11.2%) compared with patients without renal involvement (1.2%). Adverse short-term outcomes of renal involvement were associated with severity of COVID-19 pneumonia. These findings indicate that although early renal abnormalities often resolve in such patients, intensive support and careful monitoring of severe or critical illness is appropriate for COVID-19 pneumonia with renal complications.

Background

Some patients with COVID-19 pneumonia also present with kidney injury, and autopsy findings of patients who died from the illness sometimes show renal damage. However, little is known about the clinical characteristics of kidney-related complications, including hematuria, proteinuria, and AKI.

Methods

In this retrospective, single-center study in China, we analyzed data from electronic medical records of 333 hospitalized patients with COVID-19 pneumonia, including information about clinical, laboratory, radiologic, and other characteristics, as well as information about renal outcomes.

Results

We found that 251 of the 333 patients (75.4%) had abnormal urine dipstick tests or AKI. Of 198 patients with renal involvement for the median duration of 12 days, 118 (59.6%) experienced remission of pneumonia during this period, and 111 of 162 (68.5%) patients experienced remission of proteinuria. Among 35 patients who developed AKI (with AKI identified by criteria expanded somewhat beyond the 2012 Kidney Disease: Improving Global Outcomes definition), 16 (45.7%) experienced complete recovery of kidney function. We suspect that most AKI cases were intrinsic AKI. Patients with renal involvement had higher overall mortality compared with those without renal involvement (28 of 251 [11.2%] versus one of 82 [1.2%], respectively). Stepwise multivariate binary logistic regression analyses showed that severity of pneumonia was the risk factor most commonly associated with lower odds of proteinuric or hematuric remission and recovery from AKI.

Conclusions

Renal abnormalities occurred in the majority of patients with COVID-19 pneumonia. Although proteinuria, hematuria, and AKI often resolved in such patients within 3 weeks after the onset of symptoms, renal complications in COVID-19 were associated with higher mortality.
ALMANYA'DA POPÜLİST ALTERNATİF: DIE LINKE ÖRNEĞİ
Authors: ARSLANTAŞ Şenol , ARSLANTAŞ Düzgün
Published: April 2020

2007 – 2008 finansallaşmış kapitalist krizin patlak vermesinin ardından Avrupa’da ulusal hükümetlerin kemer sıkmaya yönelmesi, ağır sosyal sonuçlara yol açmıştır. Bu durum, birçok ülkede siyasi memnuniyetsizliği tetikleyerek güçlü radikal partilerin ortaya çıkmasına zemin hazırlamıştır. Ne var ki kemer sıkma çağında radikal aktörlerin eş zamanlı yükselişine rağmen siyasal partiler çalışmalarında radikal sol partilerin atılımı büyük oranda göz ardı edilmektedir. Bu boşluğun doldurulması için makalede, Almanya’da Die Linke örneklemi üzerinden radikal solun evrimi, yapısal politik ekonomik ve politik kurumsal koşullar, toplumsal protesto dinamikleri ve toplumsal hareketlilik açısından analiz edilmektedir. Die Linke’nin yükselişinde ülkede sosyal adalet talebinin temel temsilcisi haline gelerek parti sisteminde SPD’nin geleneksel olarak işgal ettiği yere kaymasının kritik bir rol oynadığı savunulmaktadır. Bununla birlikte 2013 sonrasında radikal sağ AfD’nin kamusal söylemi ve parti rekabetini belirleyen konuları tayin etmesiyle birlikte radikal solun atılım dönemi sona ermiştir
Van’ın Edremit ilçesinde turizmin gelişimi: Rezilyans ve değişim
Authors: CİHANGİR Emine , ŞEREMET Mehmet
Published: April 2020

Turizm hem gelişmekte olan hem de gelişmiş ülkeler için önemli bir istihdam yaratma ve katma değer üretme kaynağıdır. Gelişmekte olan ülkeler açısından turizmin gelişimi özellikle bölgesel ekonomik, sosyal ve kültürel dengesizliklerin ortadan kaldırılması noktasında da önemlidir. Ancak, gelişim ve kalkınma sürecinin doğrusal bir ivme ile devam etmesi çoğu zaman beklenemez. Bunun sosyal, politik, doğal ve çevresel nedenleri olabilmektedir. Bu araştırmada, Turizm Coğrafyası araştırmalarında son yıllarda kullanılan ve beklenilmeyen durumlara karşı yerel toplumların geliştirmeleri beklenilen “rezilyans” teorisi ile turizm ilişkisi ele alınmaktadır. Bu çerçevede, daha önce turizmin gelişmesi noktasında farklı olumsuz (deprem, terör, ekonomik istikrarsızlık) gibi durumlara maruz kalmış olan Van’ın Edremit ilçesi örnek alan olarak seçilmiştir. Araştırma’da veriler nitel araştırma stratejisine bağlı olarak yüz yüze mülakatlar aracılığıyla toplanmıştır. Çalışma sonucunda, yerel sektör temsilcilerinin Edremit ilçesindeki turizmin gelişimi ile değişimi sürecinde adaptasyonları eleştirel bir boyutta değerlendirilmiştir. Çalışma, özellikle rezilyans teorinin turizmle ilişkisinin yerel aktörler aracılığıyla ortaya konulması noktasında literatürde önemli bir boşluğu dolduracağı düşünülmektedir. Çalışma sonucunda, yerel işletmelerin ve sektör temsilcilerinin değişen sürece yönelik bakış açılarının olumlu olduğu, turistik ürünlerin çeşitlendirilmesi ve yenilikçi bir perspektifle sunulması noktasında fikir birliği içerisinde olduklarını ortaya çıkmaktadır. Bununla birlikte, işbirliği, birlikte hareket etme, katılımcı yönetim gibi zorlukların ise rezilyans bir turizm toplumu olma noktasında zayıf yönlerinin olduğu görülmektedir
Osteonecrose dos maxilares associada ao uso de bifosfonatos
Authors: Santos Paula Strauch Ferreira Lessa , Sobrinho Antônio Lucindo Pinto de Campos
Published: April 2020

O pirofosfato endógeno é uma substância responsável por inibir a reabsorção óssea no organismo, mas não pode ser utilizado como agente terapêutico no tratamento de doenças, já que sofre rapidamente hidrólise enzimática. Os bifosfonatos, análogos sintéticos dessa substância, apresentam-se como potentes inibidores da atividade osteoclástica, sendo escolhidos como primeira opção de tratamento para diversas doenças que se relacionam com a perda de massa óssea como osteoporose, Doença de Paget, Metástases Esqueléticas e Mieloma Múltiplo. O primeiro caso de Osteonecrose dos maxilares associada aos Bisfosfonatos (OAB) foi apresentado em 2003, e desde então diversos estudos foram realizados com o objetivo de entender o mecanismo que leva esses compostos a induzirem uma necrose dos ossos maxilares. Recentemente, novos casos de OAB associados à outra classe de antirreabsortivos, como Desonumabe, vêm chamando atenção. O objetivo desse trabalho é discutir, por meio de uma revisão da literatura, os conhecimentos acerca do mecanismo de ação desses fármacos e sua relação no atendimento dos pacientes odontológicos, buscando novas atualizações que possam auxiliar no melhor entendimento da etiopatogenia da OAB. Para realização desse estudo foi feito um levantamento bibliográfico a respeito da ocorrência de OAB, usando como bases de busca Pubmed, Scielo, Google Acadêmico e Medline de 2001 até 2018. Através desse estudo, pode-se concluir que embora diversas descobertas tenham sido feitas desde o aparecimento da patologia até o momento presente, muitas pesquisas ainda precisam ser realizadas para que se consiga chegar a um protocolo de tratamento adequado.
Inter-ethnic Relations and Bounding Agency
Authors: Kalalahti Mira
Published: April 2020

European countries are being urged to reform their educational systems to enhance the integration of migrant populations. In many respects, migrant-origin pupils still lack equal educational opportunities in Finland despite the targeted practices and support. This article concerns the inter-ethnic interaction taking place in study guidance and counselling in the final year of Finnish comprehensive school. It poses a question ‘how do young people construct their educational identities in classroom-level interactions in a multi-ethnic class’? The mixed methods research setting offers two sets of data: selective observation (two events) and life-span interviews (n = 8). The outcomes portray how multi-ethnic school classes open opportunities and supportive bridges for the pupils to contact other ethnicities. Nevertheless, the inter-ethnic interaction was also layered with societal hierarchies which constructed and bounded pupils’ ethnic and educational identities. Finally, the article emphasises the opportunities that the locality offers to the schools.
Sentinel Flask Preparation for Cold Shipping Protocol of Human Islets v1
Authors: Islet Distribution Program Integrated
Published: April 2020

To establish a standardized method for the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) sponsored research in the Integrated Islet Distribution Program (IIDP) for preparing a sentinel flask of human islets in order to monitor sterility and islet integrity at the production center. This is a representative sample of the islet preparation that has been distributed to investigators and is held at the distributing center as a quality control sample. The islets are cultured in the same shipping media used for islet shipment, for 18 hours at 4-8°C, simulating the cold shipping conditions followed by 2 days at 37°C culture. The flask of islets are verification in the event of a dispute over sterility or islet quality.
Liquid Chromatography-Mass Spectrometry/Mass Spectrometry (LC-MS/MS) for Bulk Metabolomics v1
Authors: Velickovic Dusan , Lukowski Jessica , Zhang Guanshi , Alexandrov Theodore , Anderton Chris , Sharma Kumar
Published: April 2020

Mass spectrometry imaging is an exciting technologywhich enables a simultaneous analysis of multiple molecular components directly from single cells, tissues, and organs,. In combination with histological methods, this technique provides information about the spatial distribution of molecules in various biological tissues. Particularly, MALDI-MS imaging increases the coverage of metabolites by using different matrices and ion modes. In coordination with in situ analysis of proteins, transcripts and epigenetic marks, the complementary spatial information on metabolites will establish metabolic pathways that are dominant and characteristic of disease states. We have recently developed and optimized a spatial metabolomics approach to image small molecules in human kidneys and biopsy sized material. With our combined expertise at UTHSA, PNNL and EMBL and recent advances, we have established methods for identifying metabolites in human kidneys, employed ultra-high mass resolution MS imaging for tissue analysis, and developed a bioinformatics resource (METASPACE) to annotate metabolites for anatomical localization and 3-D reconstruction. Our integrated technology can easily connect with other TIS sites to provide biochemical readouts of genes/proteins in specific tissue and cellular compartments. Although METASPACE bioinformatics provides metabolite annotations of given reliability, there may be an inherent level of ambiguity due to the lack of untargeted MS/MS fragmentation in MALDI-MSI. Metabolite annotations from MALDI-MSI and METASPACE are structurally validated using orthogonal analytical techniques such as LC-MS/MS due to its high metabolome coverage, sensitivity, and throughput. The work flow for ‘bulk omics’ is shown in Figure 5.
SARS-CoV-2 Sequencing on Illumina MiSeq Using ARTIC Protocol: Part 1 - Tiling PCR v1
Authors: Sevinsky Joel
Published: April 2020

This protocol is an adaption of several circulating protocols on SARS-CoV-2 sequencing using the ARTIC protocol. Its purpose is to simplify things for the average state public health laboratory, using equipment and expertise they currently posess, most likely from their funded PulseNet activities. This protocol is derived from other works, including: https://www.protocols.io/view/ncov-2019-sequencing-protocol-bbmuik6w https://www.protocols.io/view/ncov-2019-sequencing-protocol-v2-bdp7i5rn
LC-MS/MS Label-Free Proteomic Data Analysis Parameters v1
Authors: Allen Jamie , Gutierrez Danielle , Spraggins Jeff
Published: April 2020

List of parameters and settings for searching label free proteomic data in MaxQuant version 1.6.7.
BulkATAC - Isolation of nuclei from frozen tissue for ATAC-seq and other epigenomic assays v1
Authors: Corces Ryan , J. Greenleaf William , Y. Chang Howard , Horning Aaron
Published: April 2020

This protocol enables the isolation of nuclei from frozen tissues. These nuclei are suitable for use in ATAC-seq, single-cell ATAC-seq, ChIP-seq, HiC/3C, and many other assays.
Florisztikai adatok a Tokaj–Zempléni-hegyvidékről és környékéről
Authors: Türke Ildikó Judit , Lontay László , Serfőző József , Zsólyomi Tamás , Drozd Attila , Pelles Gábor
Published: April 2020

Cikkünkben a Tokaj–Zempléni-hegyvidék területéről és környékéről (a Szerencsközből, a Hernád-mentéről, a Bodrogközből, a Taktaközből és a Harangodból) az elmúlt évtized legfontosabb és legérdekesebb florisztikai eredményeiről számolunk be.  A Zempléni-hegységből két új védett fajt (As­plenium javorkaeanum, Epipactis nordeniorum), a Bodrogköz magyarországi részéről pedig hét új védett fajt mutattunk ki (Cephalanthera damasonium, Cirsium brachycephalum, Epilobium palustre, Epipactis palustris, Lycopodium clavatum, Pyrola rotundifolia, Polystichum aculeatum). Számos ritka faj új lelőhe­lyére bukkantunk (Epipactis exilis, Dryopteris expansa, Blechnum spicant, Androsace maxima, Orchis cori­ophora, Orchis purpurea, Dactylorhiza sambucina, Sonchus palustris, Cicuta virosa). Továbbá sikerült megerősítenünk több olyan faj adatát, amelyek már évtizedek óta nem kerültek elő (Sedum hispanicum, Erysimum wittmannii subsp. pallidiflorum, Pseudolysimachion spurium, Botrychium lunaria).
Öğretmenlerin Sosyal Medya Üzerinden Kendilerini Açmalarına İlişkin Görüşlerinin İncelenmesi
Authors: DEMİR Mustafa
Published: April 2020

Bu araştırmanın amacı, öğretmenlerin sosyal medya üzerinden kendilerini açma davranışlarının, öğretmen görüşlerine göre incelenmesidir. Bu amaç doğrultusunda araştırmada nitel araştırma desenlerinden olgubilim deseni kullanılmıştır. Araştırma kapsamında 2018–2019 eğitim öğretim yılında, farklı kademelerde görev yapan 18 öğretmen, araştırmanın katılımcıları olarak belirlenmiştir. Verilerin toplanması amacıyla araştırmacı tarafından geliştirilen üç soruluk yarı yapılandırılmış görüşme formu oluşturulmuş ve araştırmanın alt problemleri doğrultusunda veriler, katılımcılarla yapılan görüşmeler aracılığıyla toplanmıştır. Elde edilen verilerin içerik analizleri sonucunda, öğretmenlerin sosyal medyada yapmış oldukları akademik içerikli, kişisel ve özel bilgiler içeren, eğlenceli, sosyal içerikli ve güncel konularla ilgili paylaşımlar ve etkileşimler yoluyla öğrencilerine kendilerini açtıkları bulunmuştur. Öğretmenlerin, duyuru ve bilgilendirme yapma, iletişimi güçlendirme, katılımın artması ve içeriğin daha anlaşılır olması gerekçeleri ile kendilerini sosyal medya üzerinden öğrencilerine açtıkları ve öğretmenlerin sosyal medya üzerinden kendilerini açmaları sonucunda, öğrencilerin olumlu duyuşsal öğrenmeler edindiği, derse katılımlarının arttığı, içeriğin daha anlaşılır olduğu ve öğrencilerin akademik başarılarının arttığı ortaya çıkmıştır. Ayrıca öğretmenlerin sosyal medya üzerinden kendilerini öğrencilerine açmalarının öğrencilerin sınıf içi performanslarına olumlu etkilerinin de olduğu sonucuna ulaşılmıştır.
The Effectiveness of I Can Problem Solve (ICPS) Program: An Empirical Research on Preschoolers
Authors: ZORLU Hilal , ÖĞÜLMÜŞ Selahiddin
Published: April 2020

The aim of this study is to examine the effectiveness of I Can Problem Solve / ICPS Program developed by Shure (1992) of those children attending preschool education programs in the age of 4-5. This program is designed to develop children's thinking skills. The most important feature of the program is that it teaches children how to think, not what to do or think in the decision-making process for problem-solving. ICPS is a comprehensive and internationally supported program that was developed as a result of more than 25 years of studies. This research is based on real experimental models from experimental methods, pretest-posttest control group design. Experimental and control groups were composed of 34 children who attend a state preschool in Balıkesir. The researcher administered 59 sessions Interpersonal Problem-Solving Skills Education Program, adopted into Turkish form for preschool children to the experimental group for five months. Preschool Interpersonal Problem-Solving Test was used for data collection tool in the study. Independent samples t-test was used to compare the pretest of the groups. Split Plot ANOVA was used for comparing of the groups pretest and posttest scores. The findings showed that ICPS given to children was effective in developing their interpersonal problem solving skills.
Üstbilişsel Okuma Stratejileri Öğretimine Yönelik Öğrenci Görüşleri
Authors: BEKTAŞ BEDİR Sevgi , DURSUN Fevzi
Published: April 2020

Araştırmanın amacı çalışma grubuna sekiz hafta boyunca uygulanan üstbilişsel okuma stratejileri öğretimi hakkında öğrencilerin görüşlerini almaktır. Araştırmanın çalışma grubunu 2016-2017 eğitim öğretim yılında Orta Karadeniz Bölgesi’nde ki bir ilçede dokuzuncu sınıfa devam eden otuz öğrenci oluşturmaktadır. Araştırmada nitel araştırma modellerinden durum çalışması deseni kullanılmıştır. Bu araştırmada belirlenen alt amaçlara ilişkin verileri elde etmek amacıyla araştırmacılar tarafından geliştirilen yarı yapılandırılmış görüşme formu ve ders değerlendirme formu kullanılmıştır. Kendilerine üstbilişsel okuma öğretimi verilen öğrencilerden on yedisi ile yarı yapılandırılmış görüşme yapılmıştır. Ayrıca öğrencilerin tümüne her okuma parçası öğretiminden sonra ve sekiz haftalık tüm süreç tamamlandıktan sonra ders değerlendirme formu dağıtılmıştır. Yarı yapılandırılmış görüşmelerin betimsel analizi için MAXQDA 12 nitel veri analiz programı kullanılmıştır. Ders değerlendirme formu verileri de betimsel analiz yöntemi kullanılarak analiz edilmiştir. Yarı yapılandırılmış görüşme ve ders değerlendirme formunun betimsel analizi sonuçları öğrencilerin, kendilerinde hem okuma stratejilerine karşı üstbilişsel farkındalık oluştuğunu hem de İngilizce okumaya karşı öz yeterliklerinde artış olduğunu düşündüklerini göstermektedir.
«Spain for Europe» and «Europe for Spain» Concepts in Discussions of Spanish Intellectuals
Authors: Khmel Anastasiia
Published: April 2020

Concepts «Spain for Europe» and «Europe for Spain» in discussions of Spanish intellectuals.

The study analyzes the views of Spanish thinkers and historians, most notably of «Generation 98», about Spain’s role in Europe and vice versa. The problem of the conceptualizations of the notions «Spain for Europe» or «Europe for Spain» for Spain came at the end of the nineteenth – in the beginning of the twentieth century after the defeat in the war of 1898, for Ukraine it became relevant as a result of the realization of the European choice of Ukraine, since both counties were thinking at different times how to find their place in Europe and determine what they can bring to the circle of European peoples. The self-conceptualization of Spain as a member of the European family began after the defeat in the war of 1898, when Spain lost its last colonies: Cuba and the Philippines. The defeat in this war has made appear a galaxy of thinkers who have taken up the revival of Spain’s spirit, one can say of its self-esteem, power and might by explaining its place in Europe. Generation 98 has become the foundation not only for later thinkers and scholars but also for politicians. We can find their ideas in the Eurocentric discourse of F. Franco and in the speeches of his ministers. M. de Unamuno became the most famous and respected figure of this generation, and his thesis on the interpenetration of cultures as a basis for their coexistence, on the mutual development and usefulness of cultures, is a vivid realization of the symbiosis of both concepts. Therefore, the two concepts mentioned in the title can be realized in parallel and do not exclude each other.

Consequently, the concepts of «Spain for Europe» and «Europe for Spain» are originated by the Spanish thinkers and intellectuals of the generation 98. In their discourse, it is difficult to single out the dominant concept, but the most important, in our view, is the intellectual achievement of M. de Unamuno, who successfully combines the two concepts, emphasizing that «Europeanization of Spain» must occur simultaneously with the «Spanishization of Europe» because both sides have something to offer each other, especially in the spiritual scope.
Análisis prospectivo estratégico de la educación superior en Colombia
Authors: Espinal Ruiz Dario Jose , Scarpetta Calero Gildardo , Cruz Gonzalez Natali
Published: April 2020

Las universidades deben adaptarse y anticipar los desafíos emergentes para mantener su papel en la sociedad. Este artículo tiene como objetivo proponer un marco de prospectiva educativa que facilite el análisis de los futuros alternativos en las instituciones de educación superior. Se utiliza una metodología prospectiva de tipo normativa, se aplican entrevistas semi-estructuradas a expertos, como base para un análisis morfológico que oriente la definición de escenarios futuros. Los resultados permiten caracterizar el panorama estratégico de la educación superior en Colombia y se identifican las variables de mayor influencia en los procesos de acreditación institucional; específicamente se analiza el caso de la Institución Universitaria Escuela Nacional del Deporte (Valle del Cauca, Colombia). Se formulan los escenarios de futuro inercial, desarrollo incremental, cambio estructural y retroceso, que conllevan a la elaboración de recomendaciones estratégicas para el escenario apuesta. Se concluye que el análisis de prospectiva educativa propuesto integra aspectos institucionales, de internacionalización, ciencia, tecnología e innovación y proyección social para la construcción de escenarios alternativos de futuro útiles para la toma de decisiones estratégicas en las instituciones de educación superior.
The Quality of Education: A reflection from the Pedagogical Academic Management.
Authors: Peláez Henao Oscar Alberto , Gallego Henao Adriana María , González Ramírez Roger Alexander
Published: April 2020

The purpose of the research is to recognize the impact of pedagogical academic management on the educational quality of school organizations in the municipality of Santa Rosa de Osos, Medellín, Colombia and whose findings contribute knowledge to improve pedagogical and teaching-learning processes. The paradigm is historical -hemeneutic of qualitative type and as a research strategy the case study is privileged. In this order of ideas, academic and pedagogical processes are related to the quality of the educational institutions studied. It is expected in the immediate future to integrate the results in the reformulation of projects, policies and programs that seek to improve the quality of education.
Electrically Conducting Hydrogels for Health care: Concept, Fabrication Methods, and Applications
Authors: Agarwala Shweta
Published: April 2020

Electrically conducting hydrogels are gaining increasing attention due to their potential application in smart patches, biosensors, functional tissue engineering scaffolds, wound management, and implants. The current review focuses on these novel materials, their synthesis routes, and their composites. Special attention is paid to fabrication routes to produce functional composites with organic and inorganic components. The design of conductive hydrogels leads to inheritance of the advantages of each component and offers new features from the synergistic effects between the components, thus opening new application areas. The review also discusses the emerging role of 3D printing as an advanced approach toward new design, functionality, and material combination possibilities. The issue of lack of the spatial control with current techniques is highlighted, and possible new routes to solve it are discussed. The review will provide readers with knowledge tool to select appropriate methodology for designing desired hydrogel material composites.
3D-printed Biomimetic Bioactive Glass Scaffolds for Bone Regeneration in Rat Calvarial Defects
Authors: C. R. Kolan Krishna , Huang Yue-Wern , A. Semon Julie , C. Leu Ming
Published: April 2020

The pore geometry of scaffold intended for the use in the bone repair or replacement is one of the most important parameters in bone tissue engineering. It affects not only the mechanical properties of the scaffold but also the amount of bone regeneration after implantation. Scaffolds with five different architectures (cubic, spherical, x, gyroid, and diamond) at different porosities were fabricated with bioactive borate glass using the selective laser sintering (SLS) process. The compressive strength of scaffolds with porosities ranging from 60% to 30% varied from 1.7 to 15.5 MPa. The scaffold’s compressive strength decreased significantly (up to 90%) after 1-week immersion in simulated body fluids. Degradation of scaffolds is dependent on porosity, in which the scaffold with the largest surface area has the largest reduction in strength. Scaffolds with traditional cubic architecture and biomimetic diamond architecture were implanted in 4.6 mm diameter fullthickness rat calvarial defects for 6 weeks to evaluate the bone regeneration with or without bone morphogenetic protein 2 (BMP-2). Histological analysis indicated no significant difference in bone formation in the defects treated with the two different architectures. However, the defects treated with the diamond architecture scaffolds had more fibrous tissue formation and thus have the potential for faster bone formation. Overall, the results indicated that borate glass scaffolds fabricated using the SLS process have the potential for bone repair and the addition of BMP-2 significantly improves bone regeneration.
Fibrin-based Bioinks: New Tricks from an Old Dog
Authors: Shpichka Anastasia , Osipova Daria , Efremov Yuri , Bikmulina Polina , Kosheleva Nastasia , Lipina Marina , A. Bezrukov Evgeny , B. Sukhanov Roman , B. Solovieva Anna , Vosough Massoud , Timashev Peter
Published: April 2020

For the past 10 years, the main efforts of most bioprinting research teams have focused on creating new bioink formulations, rather than inventing new printing set-up concepts. New tissue-specific bioinks with good printability, shape fidelity, and biocompatibility are based on “old” (well-known) biomaterials, particularly fibrin. While the interest in fibrin-based bioinks is constantly growing, it is essential to provide a framework of material’s properties and trends. This review aims to describe the fibrin properties and application in three-dimensional bioprinting and provide a view on further development of fibrin-based bioinks.
Research on technological innovation model and performance analysis of new energy vehicles
Authors: Liu Wenting
Published: April 2020

New energy vehicles are widely used in the transportation industry of various countries in the 21st century, which not only saves energy and protects environment, but also effectively promotes the development of China's transportation industry. At present, the main energy sources used by new energy vehicles are electric power and clean fuels. To ensure the normal running, attention should be paid to innovating technological modes and analyzing performance, which is the topic of this paper.
Takotsubo syndrome. Clinical and pathogenetic aspects. Basics of diagnosis and treatment
Authors: Suspitsyna I. N. , Sukmanova I. A.
Published: April 2020

The review article presents current data on the problem of takotsubo syndrome; the authors touched upon the main issues of epidemiology, clinical picture, pathophysiological mechanisms of the disease development. The problems of diagnosis, the basic principles of therapy, as well as possible complications and outcomes are considered. The authors presented a diagnostic algorithm, as well as updated international InterTAK diagnostic criteria, according to an expert consensus document on takotsubo syndrome of the European Society of Cardiology, published in 2018.
Prevalence of Advanced Chronic Kidney Disease in Patients with Nonvalvular Atrial Fibrillation Hospitalized in Cardiology Departments
Authors: Chashkina M. I. , Kozlovskaya N. L. , Andreev D. A. , Ananicheva N. A. , Bykova A. A. , Salpagarova Z. K. , Syrkin A. L.
Published: April 2020

Objective.To estimate the prevalence of chronic kidney disease (CKD) 3b – 5 stages and the newly diagnosed sustained reduction in glomerular filtration rate (GFR) <30 ml / min / 1.73 m2 in patients with atrial fibrillation (AF) in real clinical practice, as well as the features of their anticoagulant therapy.Materials and Methods. Retrospectively, data of all discharge epicrisis from cardiological departments of five Moscow hospitals from June 1, 2016 to May 31, 2017 were analyzed. Patients over 18 years old with AF were enrolled. At the next stage, patients with CKD 3 b – 5 st and newly diagnosed sustained reduction in GFR <30 ml / min / 1.73 m2 (at least 2 measurements during hospitalization) were selected.Results.Data of 9725 patients were analyzed, AF was diagnosed in 2983 (31 %) cases, of which a decreased GFR <45 ml / min / 1.73 m2 was detected in 27 % (n = 794) cases. Among them, 349 (44 %) were diagnosed with CKD 3b st, 123 (15 %) with CKD 4 st, 44 (6 %) with CKD 5 st, 278 (35 %) had a newly diagnosed sustained reduction in GFR. In 63 % of patients with AF and GFR <45 ml / min / 1.73 m2, anemia was diagnosed, 39 % of them had moderate and severe one. 711 (89 %) patients were prescribed anticoagulants, 53 % were assigned direct oral anticoagulants (DOACs). Patients with CKD 3 b st. more often rivaroxaban 15 mg (29 %) was prescribed, with CKD 4 and CKD 5 – warfarin (48 % and 25 %, respectively), in patients with newly diagnosed sustained reduction in GFR <30 ml / min / 1.73 m2 – apixaban 10 mg / day (16.2 %).Conclusion.A quarter of patients with AF revealed a decreased GFR <45 ml / min / 1.73 m2, half of them were recommended DOACs. 42 % of patients with GFR <30 ml / min / 1.72 m2 were prescribed DOACs, 27 % – warfarin. Patients with CKD 5 st DOACs were not assigned; in half of cases, none of the anticoagulants was recommended. Most often, the dose of the prescribed anticoagulant was not counted according to GFR in patients with newly diagnosed sustained reduction in GFR <30 ml / min / 1.73 m2.
Predictors of Left Atrial Severe Fibrosis in Patients with Nonvalvular Atrial Fibrillation
Authors: Gizatulina T. P. , Martyanova L. U. , Pavlov A. V. , Shirokov N. E. , Kolunin G. V. , Belonogov D. V. , Gorbatenko E. A.
Published: April 2020

Objective The search for predictors of severe (>35 %) left atrial (LA) fibrosis in patients (pts) with nonvalvular atrial fibrillation (AF) directed for catheter ablation (CA).Materials and Methods 69 pts with nonvalvular AF (57 paroxismal and 12 persistent) aged from 32 to 69 years (mean age 57.1±8.4, 28 females) were included in the study, among them 59 pts (86 %) with arterial hypertension (AH), 24 (34.8 %) – with AH and CAD. Complete physical study, laboratory tests (including NT-proBNP level), comprehensive echocardiography were performed. As a surrogate substrate of LA fibrosis, the area of low-voltage (<0.5 mV) zones in LA was estimated in the process of voltage electroanatomic mapping, as the first stage of CA. The total square of LA fibrosis in absolute values (Sf, cm2) and in percent of total LA square (Sf%), as well as the degree of fibrosis: degree I – <5 %, II – 5–19 %, III – 20–35 %, IV – >35 % were calculated. Degree IV of fibrosis was considered as severe fibrosis.Results Extent of fibrosis didn’t depend on sex, age, body weight, presence of diabetes, CHA2DS2VASc scores, duration of AF history. There was a tendency to smaller Sf in pts with spontaneous termination of AF compared to those who required cardioversion: 7.2 cm2 (4.4; 17.1) and 12.6 cm2 (4.2; 30.5), respectively (p=0.069). Although NT-proBNP level was normal in 62 % of pts (<125 pg / ml), it was higher in Sf% ≥20 % than in Sf% <5 %: 146.0 (48.0; 276.0) and 42.8 (24.2; 91.0) pg / ml, respectively (p=0.0216). The distribution of pts by left ventricular (LV) geometry types was as follows: normal geometry (t.1) – 34, concentric remodeling (t.2) – 16, concentric LV hypertrophy (t.3) – 8, eccentric LV hypertrophy (t.4) – 11. Compared to pts with t. 1 (reference level), pts with t.3 and t.4 had higher LA volume and LV myocardial mass index, and pts with t.4 had larger end-diastolic LV volume and lower LV ejection fraction. Pts with t.4 tended to have higher Sf% than t.1: 31.1 (10.2; 46.2) and 11.2 (5.1; 28.0), respectively (p=0.053). Using logistic regression 3 independent predictors of LA severe fibrosis were detected: type 4 geometry of LV – OR=8.893 (95 % CI 1.150; 68.78), NT-proBNP >128 pg / ml – OR=6.184 (1.01; 37.99), LA volume index >34 ml / m2 – OR=5.92 (1.05; 33.38). According to ROC analysis, the area of the curve AUC = 0.839 (p<0.001), model specificity – 85.1 %, sensitivity – 70.0 %, predictive accuracy – 82.5 %.Conclusion In pts with nonvalvular AF predictors of severe (>35 %) LA fibrosis were LV geometry type in the form of eccentric LV hypertrophy, LA volume index >34 ml / m2 and NT-proBNP >128 pg / ml.
Expert Council Resolution. Practical Aspects of the Diagnosis and Correction of Potassium and Magnesium Deficiency States
Authors: Averin E. E. , Nikitin A. E. , Pozdnyak A. O. , Fedorova E. L. , Zhuk V. S. , Davydov S. I. , Fridman I. L. , Kompaniets O. G. , Kirpichnikova N. V. , Dudarenkova M. R. , Ginzburg M. L. , El Sharif M. A. , Martemyanova E. G. , Sozykin A. V.
Published: April 2020

The article analyzes properties of potassium and magnesium, which may exert vasodilatory, anti-inflammatory, anti-ischemic, antiaggregant, and antiarrhythmic effects. These are extremely important microelements and potentially beneficial therapeutic agents for treatment of cardiovascular diseases.
Pathogenetic mechanisms of development of myocardial pathology in patients with malignant tumors: the current state of the problem
Authors: Obrezan A. G. , Shcherbakova N. V.
Published: April 2020

The myocardium, which has a high metabolic activity, responds to metabolic disorders and energy imbalance induced by a growing malignant tumor. In addition, the tumor itself can produce substances that directly affect metabolic processes and the life cycle of cells not involved in the neoplastic process, including cardiomyocytes. This review summarized and systematized current data on individual aspects of detrimental effects of oncogenes and tumor-related factors on the heart muscle and morpho-functional changes in the cardiovascular system of oncology patients. Also, the authors described in detail development of these pathogenetic mechanisms.
Preparation of Electrochemical Biosensor Systems for the Analysis of Biological Objects: a Reasonable Choice of Modifications of the Working Surface of Electrodes for Performing Research in the "Smart Electrode" Mode
Authors: Shumyantseva V.V. , Agafonova L.E. , Bulko T.V. , Kuzikov A.V. , Masamrekh R.A.
Published: April 2020

The electrochemical method of analysis of biological objects based on the reaction of electro-oxidation/electro-reduction of molecules is considered. Materials and complex systems for modifying electrodes as well as methods for producing modified electrodes to increase the sensitivity of recording the flow of electrochemical reactions on the surface of the electrodes are described. Methods of electrode modifications based on synthetic lipid-like didodecyldimethylammonium bromide, gold and silver nanoparticles, one-dimensional nanoparticles based on lead compounds, titan oxide nanoparticles, dispersions of carbon nanotubes in organic solvents, in polymers with different chemical structure are considered. It is shown that the appropriate functionalization of the working electrode surface makes it possible to increase the sensitivity of the electrochemical biosensor system and decrease the limit of detection. The results are presented in the form of an algorithm applicable for selection the beneficial type of modified electrode for the corresponding electrochemical reaction and biosample analysis.