bluuebunny/crossref_metadata_2025 huggingface dataset:
Advances towards the use of gastrointestinal tumor patient-derived organoids as a therapeutic decision-making tool
Authors: Obreque Javiera , Vergara-Gómez Luis , Venegas Nicolás , Weber Helga , Owen Gareth I. , Pérez-Moreno Pablo , Leal Pamela , Roa Juan Carlos , Bizama Carolina
Published: December 2023

In December 2022 the US Food and Drug Administration (FDA) removed the requirement that drugs in development must undergo animal testing before clinical evaluation, a declaration that now demands the establishment and verification of ex vivo preclinical models that closely represent tumor complexity and that can predict therapeutic response. Fortunately, the emergence of patient-derived organoid (PDOs) culture has enabled the ex vivo mimicking of the pathophysiology of human tumors with the reassembly of tissue-specific features. These features include histopathological variability, molecular expression profiles, genetic and cellular heterogeneity of parental tissue, and furthermore growing evidence suggests the ability to predict patient therapeutic response. Concentrating on the highly lethal and heterogeneous gastrointestinal (GI) tumors, herein we present the state-of-the-art and the current methodology of PDOs. We highlight the potential additions, improvements and testing required to allow the ex vivo of study the tumor microenvironment, as well as offering commentary on the predictive value of clinical response to treatments such as chemotherapy and immunotherapy.
Role of SYVN1 in the control of airway remodeling in asthma protection by promoting SIRT2 ubiquitination and degradation
Authors: Dai Bing , Liu Si , Shen Wenxin , Chen Li , Zhou Qianlan , Han Lina , Zhang Qinzhen , Shan Lishen
Published: December 2023

Background

Asthma is a heterogenous disease that characterized by airway remodeling. SYVN1 (Synoviolin 1) acts as an E3 ligase to mediate the suppression of endoplasmic reticulum (ER) stress through ubiquitination and degradation. However, the role of SYVN1 in the pathogenesis of asthma is unclear.

Results

In the present study, an ovalbumin (OVA)-induced murine model was used to evaluate the effect of SYVN1 on asthma. An increase in SYVN1 expression was observed in the lungs of mice after OVA induction. Overexpression of SYVN1 attenuated airway inflammation, goblet cell hyperplasia and collagen deposition induced by OVA. The increased ER stress-related proteins and altered epithelial-mesenchymal transition (EMT) markers were also inhibited by SYVN1 in vivo. Next, TGF-β1-induced bronchial epithelial cells (BEAS-2B) were used to induce EMT process in vitro. Results showed that TGF-β1 stimulation downregulated the expression of SYVN1, and SYVN1 overexpression prevented ER stress response and EMT process in TGF-β1-induced cells. In addition, we identified that SYVN1 bound to SIRT2 and promoted its ubiquitination and degradation. SIRT2 overexpression abrogated the protection of SYVN1 on ER stress and EMT in vitro.

Conclusions

These data suggest that SYVN1 suppresses ER stress through the ubiquitination and degradation of SIRT2 to block EMT process, thereby protecting against airway remodeling in asthma.
Simulation-based development: shaping clinical procedures for extra-uterine life support technology
Authors: van Haren J. S. , van der Hout-van der Jagt M. B. , Meijer N. , Monincx M. , Delbressine F. L. M. , Griffith X. L. G. , Oei S. G.
Published: December 2023

Background

Research into Artificial Placenta and Artificial Womb (APAW) technology for extremely premature infants (born < 28 weeks of gestation) is currently being conducted in animal studies and shows promising results. Because of the unprecedented nature of a potential treatment and the high-risk and low incidence of occurrence, translation to the human condition is a complex task. Consequently, the obstetric procedure, the act of transferring the infant from the pregnant woman to the APAW system, has not yet been established for human patients. The use of simulation-based user-centered development allows for a safe environment in which protocols and devices can be conceptualized and tested. Our aim is to use participatory design principles in a simulation context, to gain and integrate the user perspectives in the early design phase of a protocol for this novel procedure.

Methods

Simulation protocols and prototypes were developed using an iterative participatory design approach; usability testing, including general and task-specific feedback, was obtained from participants with clinical expertise from a range of disciplines. The procedure made use of fetal and maternal manikins and included animations and protocol task cards.

Results

Physical simulation with the active participation of clinicians led to the diffusion of tacit knowledge and an iteratively formed shared understanding of the requirements and values that needed to be implemented in the procedure. At each sequel, participant input was translated into simulation protocols and design adjustments.

Conclusion

This work demonstrates that simulation-based participatory design can aid in shaping the future of clinical procedure and product development and rehearsing future implementation with healthcare professionals.
Market integration and asymmetric price transmission in selected domestic markets for major staple foods in Uganda
Authors: Waiswa Denis , Yavuz Fahri
Published: December 2023

In this study, we examined the price transmission dynamics and market integration among domestic markets for Uganda’s major staple foods (matoke, maize, and beans) utilizing the Granger causality analysis, bounds test, Wald test for long- and short-run asymmetry, and the nonlinear ARDL model. Among the key findings, the causal order between wholesale and retail commodity prices flows unidirectionally forward from the wholesale to the retail level across all markets. Wholesale and retail prices for Uganda’s staple foods are interlinked in all markets, and spatially separated markets are also well integrated. The Wald test revealed asymmetric price transmission (APT) in speed alone for the pairs wholesale and retail prices of matoke in Kampala, and wholesale prices of matoke in Mbarara with Kampala retail prices, both APT in magnitude and APT in speed for the pairs wholesale and retail prices of beans in Kampala, wholesale and retail prices of maize in Masindi, and wholesale prices of beans in Masindi with wholesale and retail prices in Kampala. We also found that in the long run, retail prices respond more strongly to wholesale price increases than decreases, an implication of positive APT in the marketing supply chain of Uganda’s major staples. This may be linked to information asymmetry between traders and consumers, traders’ adjustment costs, production levels, inventory management, and the market power of retailers. We thus concluded that final consumers are more likely to experience an increase rather than a decrease in the prices of staples at the retail level, while retailers are more likely to benefit from price decreases at the wholesale level.
İş Yerinde Psikolojik Taciz ve Nezaketsizlik: İhtiyaç Tatmininin Aracı ve Öz-Şefkatin Düzenleyici Rolü
Authors: Karanfil Derya , Demircan Yaren , Cebeci Elif Özlem , Karasakal Seçil Gözde , Yakın Nazlıcan
Published: December 2023

There are research findings showing that workplace mobbing or incivility can be contagious and targets may react to such behaviors with mistreatment. However, the relationship between mobbing experience and instigated incivility, mechanisms explaining and factors strengthening this relationship has been relatively less examined. The current study aims to examine the mediating role of need satisfaction and moderating role of self-compassion in the relationship between mobbing and instigated incivility. It is hypothesized that mobbing is positively related to instigated incivility and negatively related to need satisfaction. Moreover, need satisfaction is proposed as mediator and self-compassion as moderator in the relationship between mobbing and instigated incivility. Study data was collected from 221 employees via an online survey. Hayes Process Macro was used to test hypotheses. Results revealed that mobbing was negatively related to need satisfaction and positively related to instigated incivility. Moreover, need satisfaction mediated the relationship between mobbing and instigated workplace incivility. But, self-compassion did not moderate the relationship between mobbing and instigated incivility. Exploratory study finding revealed that self-compassion moderated the relationship between mobbing and basic need satisfaction. In conclusion, different mistreatments might trigger each other by hindering need satisfaction and self-compassion might strengthen the effects of mobbing.
O FIGITAL E O NÃO LUGAR DA ESCOLA CONTEMPORÂNEA
Authors: Angeluci Alan César Belo
Published: December 2023

Este texto propõe uma discussão sobre a urgente aproximação das práticas educacionais e dos processos de ensino-aprendizagem à cultura digital, buscando compreender como a escola pode se aproximar da realidade de vida de jovens alunos. O texto parte de uma ideia de crise de linguagem que afeta a educação e destaca como a linguagem midiático-digital de edutubers, booktukers e outros influenciadores digitais têm dado indícios de caminhos para aproximação entre jovens alunos e a escola, onde ainda impera um modelo apegado aos rituais tradicionais, com atualizações paquidérmicas. O argumento central do texto situa-se em reconhecer o “figital” – o hibridismo contemporâneo e a necessidade da convivência dos artefatos físicos e digitais – mas alerta para a tendência de um pensamento que reduz o espaço da educação a um mero espaço de consumo. Por fim, apoia-se nos preceitos da pedagogia dos multiletramentos e da literacia transmídia como possíveis caminhos para práticas educativas mais atentas, éticas e conscientes à realidade da vida contemporânea.
Sensor Data Fusion using Kalman Filter for LAPAN-A2 Satellite Attitude Estimation
Authors: AKMAL Shabri C. , POETRO Ridanto Eko , SEMBIRING Javensius , UTAMA Satriya
Published: December 2023

LAPAN A2 is a Low Earth Orbit (LEO) satellite with the primary mission to monitor the area. In order to fulfil the mission’s objectives, the Satellite attitude must be controlled properly. One of the control processes under consideration is the output attitude estimation. Attitude estimation processes in satellites mostly use satellite sensor output transformation. The estimation process, however, cannot be carried out with only one sensor where the generated transformation does not represent the satellite actual attitude. Thus, a fusion of two or more attitude sensors is needed. However, measurement noise, such as the effect of the Earth's albedo on the sun sensor and the interference of the Earth's magnetic
field on the magnetometer, is incorporated into the estimation process. Thus, a filtering process is needed. Hence, this study aims to investigate the utilization of the sensor output raw data fusion combined with the Kalman Filter algorithm to estimate the LAPAN-A2 satellite attitude in the form of Euler angle.
Oil displacement in capillary tubes using viscoelastic fluids
Authors: RASUCEANU Ioana , PATRASCU Claudiu , BALAN Corneliu
Published: December 2023

Capillary invasion of liquid is a spontaneous phenomenon that occurs at length scales smaller than the capillary length. By means of capillary action, numerous applications have been developed. We investigate the time-dependent displacement of a Newtonian oil using viscoelastic polyethylene oxide solutions. The setup implies a capillary tube in a horizontal configuration that was partially prefilled with oil. We emphasize the prefilling liquid’s role in the dynamics of the system and show the influence of the displacing liquid’s viscoelastic properties. We find significant changes in the capillary regime as the displacing liquid’s viscoelastic properties change.
The effects of distributed electric propulsion on the aerodynamics of a regional aircraft wing
Authors: CHELEMEN Dennis Stefan , BUNESCU Ionut , PRICOP Mihai-Victor , STOICAN Mihaita-Gilbert
Published: December 2023

A study is performed to comprehensively evaluate the aerodynamic performance of a regional aircraft designed for short-haul flights, with a particular focus on the effects of distributed electric propulsion (DEP) on aerodynamic performances. This effort aligns well with a core objective of the Clean Aviation program to decrease carbon emissions within the aviation sector. To address this challenge, we propose a concept that considers incorporating electric motors to complement the conventional propulsion system of a regional aircraft wing. These electric motors have the capability to draw power from either the traditional turboprop engine or exclusively from an on-board electrical generator, providing an innovative pathway for emissions reduction. The central focus of this study revolves around a detailed examination of the aerodynamic efficacy with respect to the placement of engines within the wing. It seeks to ascertain whether optimal aerodynamic efficiency is achieved through the adoption of a greater number of smaller-diameter motors, characterized by reduced power output to the shaft. Alternatively, the study explores the prospect of employing a reduced number of motors, each possessing larger diameters and correspondingly augmented power output. While a larger motor size may intuitively suggest superiority in terms of thrust, it remains imperative to meticulously evaluate the potential influence of the associated drag factor. This research contributes to the growing body of knowledge in the realm of aviation by shedding light on the intricate interaction between aerodynamic efficiency and power output in the context of propulsion system design.
The analytical and numerical study of alternative fuel injectors for the purpose of reducing chemical pollution in aviation sector
Authors: CICAN Grigore , ICHIM Georgiana Cristina
Published: December 2023

In this paper, both analytical and numerical analyses are conducted to study the behavior of a simplex time injector with a swirl chamber represented by a pin, designed to operate with kerosene. In an effort to reduce chemical pollution, the injector's performance when operating with alternative fuels such as biofuel and ethanol is investigated. Calculations have been performed to analyze the use of these three fuels at various pressures up to 100 bar. Analytical calculations were used to determine parameters such as spray angle, droplet size, fuel film thickness, and more. For a better visualization of the phenomena occurring during the injector's operation with these three fuels, numerical simulations were carried out using ANSYS, and the spray of droplets at various pressures at the injector inlet was presented. The study revealed that among the liquids studied, ethanol is the most optimal fuel. Ethanol has low viscosity and low density, making it easier to atomize by our injector compared to pure biofuel, which has higher density and viscosity values. The calculations demonstrated the qualities of ethanol following atomization, including a thin liquid film, a wide spray angle consisting of small-sized droplets, at any pressure difference, compared to the other studied fuels. It was observed that pressure difference has a significant impact on the atomization of a liquid. The best atomization qualities and optimal values were achieved when the pressure difference is high.
Synthesis, Spectroscopic, Computational Structure Analysis, Molecular Docking, in vitro Antibacterial and in vivo Antipyretic Investigations of Transition Metal(II) Complexes
Authors: Yogalakshmi P. , Banumathi N.
Published: December 2023

Unsymmetrical Schiff base hydrazone complexes of cobalt(II), nickel(II) and zinc(II) were synthesized from oxalic dihydrazide, salicylaldehyde and ethyl acetoacetate. The ligand and its metal(II) complexes were characterized by elemental analysis, UV-visible, FT-IR, molar conductivity. To determine the biological activity, in vivo antipyretic as well as in vitro antibacterial activities were conducted along with molecular docking simulation, HOMO-LUMO and MEP calculations. The findings from the experimental and molecular docking investigations demonstrated that the ligand and all the metal(II) complexes has an ability to interact with E. coli 24kDa domain protein (PDB: 1KZN). Furthermore, these interactions were accompanied by favourable docking score values, indicating potential therapeutic implications. The quantum parameters and geometric optimization of the ligand and complexes were performed using DFT simulations.
Synthesis of Novel Series of 1,2,3-Triazoles Tethered to Pyrazolo[3,4-d]pyrimidine Scaffold with Methoxyphenoxy Linker
Authors: Kandula Kotaiah , Myakala Nagaraju , Rayala Nagamani , Kuna Satheesh , Vodnala Sumathi , Thumma Vishnu , Bhavani A.K.D.
Published: December 2023

A novel series of hybrid heterocycles having pyrazolopyrimidine based 1,2,3-triazole scaffold with two ether linkages were synthesized by 1,3-dipolar cycloaddition reaction of pyrazolopyrimidines tethered to phenoxy alkynes and differently substituted aromatic azides using CuSO4·5H2O and sodium ascorbate mixture as catalyst in DMSO-H2O solvent mixture. The synthesized triazole hybrids were characterized by using various spectroscopic techniques.
Effective removal of selective heavy metal ions from aqueous solution through green synthesized zinc oxide nanoparticles
Authors: Kashyap Komal , Moharana Maheswata , Agrawal Sonalika , Pattanayak Subrat Kumar , Khan Fahmida
Published: December 2023

The presence of pollutants such as harmful heavy metals in aqueous system is currently one of the largest environmental problems. Due to unmanaged discharge from numerous industries, this system is a serious problem in the major cities of developing nations. Due to the adverse effects on the environment and potential to cause cancer in humans, these contaminants are anticipated to require special consideration. Pollution clearance is a difficult problem that needs to be tackled if adverse effects on people and the environment are to be avoided or minimized. The main objective of this present research is to synthesize zinc oxide nanoiparticles (ZnO-NPs) from Nyctanthus arbor-tristis flower in a safe, non-toxic, and ecologically friendly manner. The adsorption of U(VI), Pb(II), Cr(VI) and Cd(II) ions from aqueous solutions by Nyctanthus arbor-tristis flower extract was investigated under laboratory conditions to assess its potential in removing these metal ions. The impacts of the experimental factors, such as ZnO-NPs dosage, solution pH, and contact time, were investigated. The study shows that the majority of the toxic metal ions can be adsorbed from the solution in a relatively short duration of time under ambient conditions. The adsorption behavior of toxic metal ions onto the ZnO-NPs was analyzed with Freundlich as well as Langmuir rate equations and the results were supported by the pseudo-second-order kinetic models. The study provides a safe, non-toxic, and eco-friendly green synthesis method and also demonstrated excellent performance of the synthesized ZnO-NPs.
Liposomes-The 21st Century’s Drug Delivery System: Developments in the Last Two Decade
Authors: Adhikari Chandan
Published: December 2023

Liposomes have been thoroughly investigated and are utilized for various illnesses for the past few decades starting from its first discovery in 1961. Since then, therapeutic efficiency of liposomes is enhanced by increasing drug absorbance while fast deterioration and adverse effects are avoided or minimized. This will extend the biological halfway life. Liposomes are more attractive for usage as drug delivery carriers with all of these characteristics and versatility to modify their surface to create additional specific functionalities. In various phases of research, there are numerous new liposomal compositions that improve the therapeutic efficiency of new and old medicines used in pre-clinical and clinical studies. Current multimodal imaging advances aimed at better diagnosing and monitoring liposome therapies as diagnostic tools. Liposomes are major possibilities for medication delivery improvement. Recent researches show that the liposomes can be taken widely in cancer treatments. The primary properties of these structures include minimal toxicity, cytocompatibility, reduced clearance rates, tissue targeting and sustained drug release. Liposomes offer a variety of benefits as shown by approval of Doxil, as compared to traditional chemotherapy with free medication treatment. There are a multitude of liposomes depending on their size, lamellar number, shape and composition. Diagnostic, therapeutic, improved vaccination are covered by clinical use of these systems. Drug and gene delivery are two therapeutic aspects, where due to their unique characteristics liposomes might be beneficial. Several illnesses have been examined with respect to the participation of liposomes, with some good results. Cancer is a life-threatening disease. These structures have been examined in this respect, both in imaging and in chemotherapy. These investigations have resulted in different liposome compositions in different clinical stages. We take this great opportunity to present various surface functionalization strategies and bio-applications of liposomes developed during the last two decades covering the notable work published from 2011 to 2021 in this review. In addition, we provide opinions on the liposome industry, its commercial market and the prospective developments in the field of liposome technology. It is anticipated that this review will serve as a valuable resource, fostering interest and engagement among scientists worldwide in the field of liposome research.
Effect of Cobalt Doping on Gas Sensing Properties of SnO2 Thick Films Prepared by Chemical Co-Precipitation Method
Authors: Bagul V.R. , Bhagure G.R. , Tayde D.T.
Published: December 2023

Co-precipitation method was used for the preparation of undoped SnO2 and n-type semiconductor nanomaterials of cobalt-doped SnO2. To identify the crystalline phase and morphology of the nanomaterials were characterized by X-ray powder diffraction and scanning electron microscopy. To focus and study on the gas sensing behaviour of undoped SnO2 and modified Co-doped SnO2 thick films. To study there sensitivity among the toxic, flammable and hazardous ethanol, hydrogen sulphide, nitrogen dioxide and ammonia gases. The optimum working temperature for the nanomaterial is same as per the variable gas sensitivity.
Extraction and Volatile Compounds in Ginger Essential Oil (Zingiber officinale Roscoe) at Laboratory Scale
Authors: Thao Chi Bich , Tran Thi Tuu , Tran Thi Kim Ngan , Mai Huynh Cang
Published: December 2023

Ginger (Zingiber officinale Roscoe) has a characteristic pungent taste and contains biologically active substances with many potential benefits for use in many different fields. Ginger essential oil is extracted from ginger root (Zingiber officinale) through steam distillation. The main compound in the essential oil was determined by the gas chromatography-mass spectrometry method and evaluated antioxidant activity by measuring DPPH. Essential oil of ginger yields 2.65 mL/g and comprises the primary chemical constituents such as zingiberene (18.95 %) which is the fragrance ingredient for the characteristic scent of ginger and some other ingredients camphene, b-phellandrene, a-citral, eucalyptol, sesquiphellandrene, a-farnesene, a-pinene, etc. The antioxidant activity of ginger essential oil was evaluated by the DPPH (2,2-diphenyl-1-picrylhydrazyl) method with radical scavenging ability and oxidation reached 74.19%. The present work was carried out for the purpose of developing products and applying ginger essential oil in the fields of pharmaceutical, cosmetic and food industries, clarifying the advantages and disadvantages and improving the value of ginger in different regions locally.
Synthesis and Evaluation of Anticancer Potential of Novel Benzopyran Derivatives Using MTT and in vitro Scratch Assays
Authors: Manogaran Y. , Karupiah S. , Balakrishnan V. , Fuloria N. K. , Fuloria S.
Published: December 2023

Evidence over benzopyrans and azomethines high anticancer potential, intended present study to carry out the synthesis, characterization and anticancer activity of some new benzopyrans derivatives (NBD). Study involved synthesis of N'-(substituted benzylidene)-2-(2-oxo-2H-benzopyran-4-yloxy)acetohydrazide (2a-d) by hydrazination of substituted benzopyran ester (1). The structures of all the synthesized benzopyran derivatives (NBD 2a-d) were elucidated based on the IR, 1H NMR, 13C NMR and mass spectral data. The NBD 2a-d were further investigated for their cell viability (toxicity analysis) against HEK-293 and anticancer potential against MCF-7 cancer cell lines using MTT assay and in vitro scratch assay. Present study revealed that NBD 2a-d structures were in agreement with their IR, NMR and mass spectrometric characterization data. The cell viability study, MTT and in vitro scratch assay of NBD 2a-d, revealed compound 2d to exhibit highest anticancer activity and safety when compared with standard (irinotecan). Present study concludes NBD 2d to possess high anticancer potential and proven to be safer when compared with irinotecan, however further studies are needed to establish its clinical significance.
Facile Synthesis of Core-Shell Nanoparticles Silver/Cr2O3 Embedded with Ultrathin MoS2 Layers, Microstructure Analysis and Biocompatibility Enhancement by in vitro Evaluation of Antiproliferation and Antibacterial Activities
Authors: Lakshmidevi M. , Suresh L. , Prabu S. , Bhakya Lakshmi E. , Vasanthi P. , Kala E. , Kayalvizhi M.
Published: December 2023

Cost-effective methods were employed in this study to synthesize core-shell nanoparticles of silver/Cr2O3 (SM) embedded with ultrathin MoS2 layers (SM1) to increase the properties and biocompatibility of the nanomaterials. For structural and morphological investigation, powder XRD, TEM, SEM, EDAX and XPS were used. Magnetic behaviour of SM and SM1 nanoparticles investigated by VSM was shown to be ferromagnetic, and when MoS2 nanosheets were injected, their magnetism decreased. The zeta potential of SM1 was also analyzed. This nanomaterial was synthesized to test the biocompatibility effectiveness of anticancer and antibacterial compounds. In MCF-7 adenocarcinoma (breast cancer) and HepG-2 hepatocellular carcinoma (liver cancer) cell lines, SM1 was investigated for antiproliferation effectiveness. The MCF-7 and HepG-2 cell lines both showed strong cytotoxic potential. Antimicrobial activity was observed against Staphylococcus aureus and Escherichia coli. This study provides strong evidence to support the development of cytotoxicity and antimicrobial properties for significant biomedical compatibility by demonstrating a key to understanding the Ag/Cr2O3 nanoparticle embedded in 2D MoS2 nanosheets on forming a unique interaction as well as the strategy for achieving in vitro efficiency.
Effect of pH of Medium and Initial Salt Quantity on Release Behaviour of Potassium Chloride from Leached Poly(vinyl alcohol)/Glutaraldehyde
Authors: Hendrawan Hendrawan , Aziz Hafiz Aji , Khoerunnisa Fitri , Fajriyah Rena Rizky , Indriati Diah
Published: December 2023

The purpose of present work is to study the release kinetics of KCl from leached poly(vinyl alcohol)/glutaraldehyde (PVA/GA) hydrogelsinto demineralized water under various pH conditions. The PVA/GA hydrogels, which was prepared by mixing method, were leachedseveral times using demineralized water. The physico-chemical properties of the hydrogels were investigated using FT-IR and SEMtechniques. The release kinetics of KCl from the hydrogel into the demineralized water at various pH conditions and initial quantity ofKCl inside the hydrogel were studied using conductometric method. It was found that the trapped residual inside the hydrogel matrix can be well removed by repeated leaching. The pH of medium affects the rate of release and the amount of KCl at equilibrium conditions. The kinetics of KCl desorption into the media follows pseudo first-order kinetics, which indicates that the release kinetics is controlled by the initial amount of KCl in the PVA/GA matrix.
Inorganic Metal Oxides and Multi-Component Nanocomposites Based Photocatalysts for the Superior Degradation of Pollutants from Water
Authors: Kokila Selvasubramanian , Nesaraj Arputharaj Samson
Published: December 2023

Water is a primary and essential source of every living organism and it is a most precious gift of Mother Nature which helps every living creature to survive. However, this water is highly polluted now-a-days by various unethical activities by human beings.  Many industrial units like textile mills, pharmaceutical units, mines, paper mills, dyeing units, sugar industries, leather purifying units, electroplating plants, fine chemical units, oil refineries, etc. produce huge amount waste products in the form of toxic chemicals and pollutants every day and enter the water bodies without proper treatment. Various techniques are available to purify the polluted water by eliminating the toxicity of pollutants; some of them are reverse osmosis, electrode ionization, ion exchange, submicron filtrations, etc. Among all these water treatment procedures, photocatalysis is found to be most versatile, low cost and environmentally benign technique. In this review,  a prime focus is given on the performance of  different photocatalysts based on ZnO, CuO, NiO, SnO2, MgO, multicomponent metal oxides and composites in degrading and removing unwanted impurities present in polluted water. The importance of using metal oxide based photocatalyts in treating the polluted water is also discussed.
Noncyclic Diaza Ligands and Their Metal Complexes: Synthesis, Characterization, and Biological Studies
Authors: Sarker Pranta , Chakraborty Avijit , Rabi Saswata , Paul Pradip , Biswas Foni Bushon , Barua Kanak , Rahman Ismail M. M. , Ghosh Roy Tapashi
Published: December 2023

Condensation reactions involving various ketones and amines formed noncyclic ligands denoted as LI, LII, LIII, and LIV. Ethylenediamine, when reacted with acetophenone, benzoylacetone (in the presence of 70% HClO4), and benzophenone, resulted in the following noncyclic ligands: (E,E)-N,N-bis(1-phenylethylidene)ethylenediamine (LI), bis(1-3-hydroxy-3-phenylbut-2-ene-ylidene) (LII) and (E,E)-N,N-bis(1,1-diphenylmethylidene)ethylenediamine (LIII), respectively. The reaction of benzophenone with 1,3-diaminopropane in a 1:1 ratio in a methanolic solution also led to the synthesis of a noncyclic ligand, (E,E)-N,N-bis(1,1-diphenylmethylidene)propylenediamine (LIV). All the synthesized noncyclic ligands, except LII, undergo decomposition during complexation, reverting to the initial ketones and amines. In contrast, LII exhibits remarkable stability and can form square planar complexes with Ni(II), Cu(II), and Co(II) salts. Additionally, the Co(II) complex can convert into a six-coordinated Co(III) complex, [CoLII(H2O)2](NCS), when it reacts with KNCS. All these ligands and derived metal complexes were characterized, and their antimicrobial properties were evaluated against the selected fungi and bacteria.
Limiting molar conductivity behaviour of ENR-50 electrolyte in mixed solvent system at ambient temperature
Authors: Mohd Tajudin Mohd Afieq , Hanibah Hussein , Darji Dazylah
Published: December 2023

The present research investigates the behaviour of the limiting molar conductivity (Λo) of ENR-50/LiClO4 in a mixed solvent systemcomprising tetrahydrofuran (THF) and acetonitrile (ACN) at ambient temperature. The study uses the power law, to determine the Λovalue of ENR-50/LiClO4/THF:ACN at a specific reference salt concentration. The ENR-50/LiClO4 electrolyte system was prepared witha fixed THF:ACN ratio of 8:2, at different ENR-50 concentration of range between 0.001-0.003 g/cm3. The correlation values obtainedfor the three polymer concentrations ranged from 0.9959 to 0.9966. Regression analysis revealed that as the polymer concentrationincreases, the Λo decreases, indicating an inverse relationship which suggesting an enhanced ion dissociation due to an increase in total free-moving ions within the liquid polymer electrolyte system. The characterization of ENR-50/LiClO4/THF:ACN was verified through ATR-FTIR spectroscopy, confirming the ion dipole interaction between the C-O-C group of ENR-50 and Li ions.
Geometrical Optimization and Natural Bond Orbital Analysis of Relevant Structures in the Diastereoselective Cuprate Conjugate Addition Reaction of α,β-Unsaturated Lactams using Density Functional Theory
Authors: Arisha Anan
Published: December 2023

In this study, density functional theory calculations at the wB97XD/Def2TZVPP level were performed to analyze the mechanism underlying the cuprate conjugate addition reaction of α,β-unsaturated lactams. The calculation results were well-aligned with those obtained experimentally–the keto-aminal and aldo-aminal, i.e. 2 and 1a, yield the syn- and anti-products, respectively. The diastereoselectivity reversal originates from the small differences in the structure of the reactants. The pyramidalization and C7N3C2 angle between the aminal carbon, nitrogen and carbonyl carbon are large in 2. The dihedral angle of the aminal oxygen, aminal  carbon, nitrogen and carbonyl carbon, O8C7N3C2, is closer to 180º in 2 than in 1a. The NBO analysis revealed string interactions between the lone pair of N3 and carbonyl π*(O1–C2) bond. These results validate the assumption—the planarity around nitrogen in molecule 2 increases the nucleophilicity of the carbonyl oxygen, thereby driving the reaction between molecule 2 and trimethylsilyl  chloride (TMSCl), which yields a siloxyiminium cation 5b and this 5b propels the syn addition of dimethylcuprate, leading to the  formation of complex 7. The π(C5–C6) (HOMO) and π*(C2–N3) (LUMO) interactions in the siloxyiminium cation explain the increased  C5–C6 double bond electrophilicity. The aldo-aminal 1a directly reacts with dimethylcuprate under steric control and yields the anti  complex 6a, whose π character is stronger than that of the syn complex 7 and this weak π characteristics of 7 increases its stability to  compensate for the trimethylsilyl disturbance. The bicyclic α,β-unsaturated lactam 8 does not contain aminal oxygen and thus remains  unreactive during the cuprate conjugate addition reaction. Moreover, its pyramidalization is higher than that of the keto-aminal 2 and  its dihedral angle of C8C7N3C2 is closer to 180º. Finally, a thermodynamic anti product is obtained, which is more stable than the syn- product because of less torsional strain.
Exploring Self-Assembled Cationic Nanostructures of Amphiphilic β-Peptides for Amplifying Drug Delivery Efficiency
Authors: Goel R. , Mangal M. , Sharma A. , Kumar P. , Gupta A.
Published: December 2023

In this study, a set of short sequences of amphiphilic peptides composed of synthetic amino acids β-alanine and ornithine were designed. The synthesis of these peptides was carried out in a solution phase and then self-assembled into cationic nanostructures. The formation of cationic nanostructures was confirmed using dynamic light scattering (DLS) and the morphology of the nanostructures was studied using transmission electron microscopy (TEM), which revealed that the nanostructure adopted a spherical shape. To gain insight into the conformation of both solid samples and peptide solutions, the Fourier transform infrared (FTIR) and circular dichroism (CD) spectroscopic analysis were performed. Furthermore, the ability of these nanostructures to encapsulate hydrophobic drugs were also investigated. Three different drugs were tested as model drugs: L-dopa, an anti-Parkinson’s drug; curcumin, anti-cancerous drug and tetrabenazine, anti-Huntington’s drug. The nanostructures exhibited the capacity to encapsulate these drugs in varying ratios.
PREFERENSI CALON PEMIMPIN DI PEMILIHAN UMUM TAHUN 2024 DALAM PEMBERITAAN MEDIA ONLINE
Authors: Larasati Yuniar Galuh , Fernando Henky
Published: December 2023

Preferences for 2024 leaders can be seen from the electability of leaders in the 2019 general election. This preference indicates that the prospective leaders who will emerge in the 2024 general election are a continuation of political activity in 2019. This study aims to explain the preferences of prospective leaders in the 2024 general election. Because so far there are still few studies that pay special attention to the preferences of prospective leaders in the context of futuristic elections. This research is descriptive qualitative in nature. Data collection was conducted through a process of reading 1,000 online news articles using the search keywords "2019 and 2024 general elections in Indonesia" on the Google search engine. The analysis in this study was conducted by reducing, describing, and interpreting the data thematically inductively. The findings in this study show that the preferences of prospective leaders in the 2024 general election are not much different in terms of profession or social status. This study also recommends the importance of research that analyzes the preferences of prospective leaders in the 2024 elections with a more empirical approach.
STRATEGI PEMASARAN PARIWISATA PASCA PANDEMI: KESIAPAN DAN KOMPETENSI PRODUKSI VIDEO PARA PEGIAT WISATA DI KABUPATEN BATANG
Authors: Naryoso Agus , Hasani Mj Rizqon
Published: December 2023

The Batang Regency Government has launched the Batang Visit Year 2022 since 2017. This is an effort of the Batang Regency Government to improve the community's economy in the tourism sector. The Batang Regency Government has also renovated several tourist attractions that attract tourists. Problems arise when Indonesia is hit by the corona outbreak which also hit the tourism sector. After the corona pandemic ended, the tourism sector recovered, but needs huge promotions, including producing tourism video by local tourism communities. The research aims to determine post-pandemic tourism marketing strategies, especially the readiness and video production competence of Batang Regency tourism activists. The research used a qualitative approach and descriptive analysis methods with research subjects being tourism activists in the Pandansari Tourism Activist Community, Blado District, Batang Regency, Batang Regency. The results of the research show that tourism activists in Batang Regency already have the readiness and competence to produce tourism videos, both from the planning process, shooting execution to image editing, including using videos as tourism promotional material according to the chosen promotional media platform. Tourism activists have also produced video works that can be seen on the Batang district tourism community media account.
NEGOSIASI IDENTITAS TRANSGENDER (Studi pada Komunitas Transgender PERWAJO Kota Jombang)
Authors: Hapsari Alfaridza Ainun , Suryandari Nikmah
Published: December 2023

Transgender identity is still a pro and con for some people in Indonesia, especially in areas with high culture and religiosity. Transgender people are considered not to heed the norms prevailing in the environment. This study aims to analyze the identity negotiations of members of the transgender community in the city of Jombang Persatuan Waria Jombang (PERWAJO). The theories and concepts used in this study are identity negotiations, and transgender. This research uses qualitative descriptive research methods, as well as phenomenological approaches. The results of the study showed: Efforts to open up transgender members of the Jombang Waria Association (PERWAJO). PERWAJO members made an early opening by constructing appearance and behavior to be feminine. In addition, PERWAJO members also participate in various types of communities in their environment; PERWAJO became the medium for opening up transgender identity. Obstacles in opening up identity come from society, family, and environment.
The Influence of The Work Environment on Employee Performance
Authors: Arbyan Alviara Citra , Riyanto Setyo
Published: December 2023

The study aims to illustrate and analyze the impact of the work environment on employee performance. This research is the study of explanations. The data analysis used is a descriptive analysis and some linear regression analysis. Studies show that a descriptive analysis indicates that the respondents approved of the majority of physical and non-physical work environments that a company has improved employee performance. The results of a double regression analysis suggest that the physical environment of part-time labor has a significant impact on employee's performance and a non-physical work environment also has a significant impact on workers' performance. Test results show both the physical working environment simultaneously and the non-physical work environment has significant effects on employee performance.
Marketing of Sharia Halal Beach Tourism Through E-WOM
Authors: Ridho Armita Wahyu , Riyanto Setyo
Published: December 2023

At this time it is estimated that 207 million people embrace Islam. Of the 207 million inhabitants of the Muslim population 13% of the world's Muslims live in Indonesia and also implies that the majority of Indonesia's population adheres to the religion of Islam. Halal tourism is a tourism activity that is devoted to facilitating the Muslim travel needs. The term halal tourism emerged in 2015 when a World Halal Tourism Summit event was held in Abu Dhabi. Community activities in sharing their experiences through social media are Electronic Word of Mouth (e-WOM) activities. E-WOM activities usually use social media such as Instagram, Facebook, Path, Twitter, etc.Keywords: Marketing, Wisata Halal, E-WOM
Hubungan Antara Transisi Pemasaran dari Pemasaran Tradisional ke Pemasaran Digital dengan Volume Penjualan (Studi Pada Usaha Mikro Kecil dan Menengah di Kota Tangerang)
Authors: Salendar Aqshal Virgiananda , Raharjo Susilo Toto
Published: December 2023

This study is intended to describe the effect of digital marketing on the increase in sales volume of MSMEs. The problems in this study include how much increase in sales volume after implementing digital marketing and the reasons why business owners do not implement digital marketing. The purpose of this study is to determine the effect of digital marketing on product sales volume, and to find out the factors that cause entrepreneurs not to implement digital marketing This research is a qualitative type of research with a phenomenological approach. Data collection is done by in-depth interview method. The resource persons in this study were the owners of Micro, Small and Medium Enterprises in Tangerang which opened 10 people. The findings in this study include three things: (1) The reason why business owners switch to digital marketing, namely the decline in business sales, (2) Does sales volume increases after implementing digital marketing, which is 80% to 200%, (3) The reason why owners the business does not or has not implemented digital marketing, which includes the incompatibility of business with the application of digital marketing; digital marketing is felt to be inefficient and complicated as well as competition with suppliersKeywords: marketing transition, digital marketing, sales volume, e-commerce
The effect of weathering on drillability of dolomites
Authors: Bilen Candan , Sakız Utku
Published: December 2023

In this study, an aggregate quarry was investigated in order to understand the impact of weathering phenomenon on the drillability of dolomite stones, respectively. Samples were collected from the study area and analyzed in terms of physicomechanical tests (specific gravity, dry unit weight, uniaxial compressive strength, point load index (Is50), and Brazillian tensile strength). The drillability of the rocks was investigated using the drilling rate index method. Based on the analysis results, significant relationships were obtained between physicomechanical properties and drillability of dolomites at different weathering grades. Initial evaluations can be interpreted as an increase in the weathering degree would result in an increase in drillability. This understanding of weathering's impact on drillability is actually the main purpose of this study. This article could be a tool as regards initial evaluations of the drillability of dolomites combined with the weathering mechanism, since successful evaluations and meaningful relations were achieved.
Noise masking of near-surface scattering (heterogeneities) on subsurface seismic reflectivity
Authors: Harbi Hussein M. , Atef Ali H.
Published: December 2023

Near-surface velocity variations are the main cause of seismic scattering in exploration seismology. Many studies create the near-surface heterogeneity as velocity models that have random velocity distribution, random objects, or irregular subsurface topography to study and mitigate the resultant scattering effects of the near-surface layer. Von Kármán (self-similar) method is a known method in the literatures for modeling heterogeneous earth in a statistical way. This research modifies the self-similar method, and throughout the work, it has proven that the self-similar provides a robust method for generating realistic near-surface velocity models with different spatial velocity distributions. This study creates four-velocity models with simple subsurface layering and structure, three of which include a near-surface layer in three different degrees of velocity heterogeneity. Synthetic acoustic seismic reflections are produced for the four-velocity models to investigate the resultant scattering effects of the near-surface velocity heterogeneity on the quality of seismic waveform coherency. Spectacular negative observations are witnessed of the near-surface layer involvement to the quality of seismic reflection coherency that increases as velocity dramatically varies. Subtracting the scattering noise, which is modeled using an exact heterogeneous model, enhances seismic reflection coherency for the subsurface layers, but waveforms that are affected by scattering must be reconstructed for true amplitude and seismic waveform analysis.
Navigating whiteness from the margins: Finnish, Somali, and Arabic speakers’ experiences of racialization, (in)visibility, and (im)mobility in Gothenburg, Sweden
Authors: Löfdahl Maria , Järlehed Johan , Wojahn Daniel , Milani Tommaso M. , Rosendal Tove , Nielsen Helle Lykke
Published: December 2023

This paper examines the relationship between language, (in)visibility, and (im)mobility in racialized spaces, focusing on Finnish, Somali, and Arabic speakers in Sweden. Using a theoretical framework based on hegemonic whiteness and intersectionality, the study explores how multilingual practices and subjectivities intersect with race, religion, gender, and class to shape social visibility and mobility. The research draws on linguistic ethnographic data, including interviews, linguistic landscape documentation, and an analysis of the media discourse. The study finds that while Finnish speakers have become invisible due to assimilation policies, Somali and Arabic speakers are hypervisible in Swedish public spaces and discourse, although Arabic speakers are sometimes, and in relation to other migrants, nearing Swedish whiteness. However, all three languages and their speakers are constrained by a white normativity that reproduces inequality. The paper challenges simplistic notions of mobility/immobility and visibility/invisibility in the context of a changing racial order in Sweden, where whiteness serves as a binary sorting mechanism that perpetuates inequality. Overall, this research sheds light on the complex entanglement of language, visibility, and mobility in white spaces and contributes to a more nuanced understanding of the intersectional dynamics of race and language.