bluuebunny/crossref_metadata_2025 huggingface dataset:
Pharmacokinetics of Orally Administered Prednisolone in Alpacas
Authors: Videla Ricardo , Sommardahl Carla , Smith Joe , Schaefer Deanna M. W. , Cox Sherry
Published: October 2021

This study aimed to determine the pharmacokinetics of prednisolone following intravenous and oral administration in healthy adult alpacas. Healthy adult alpacas were given prednisolone (IV, n = 4), as well as orally (PO, n = 6). Prednisolone was administered IV once (1 mg/kg). Oral administration was once daily for 5 days (2 mg/kg). Each treatment was separated by a minimum 4 month washout period. Samples were collected at 0 (pre-administration), 0.083, 0.167, 0.25, 0.5, 0.75, 1, 2, 4, 8, 12, and 24 h after IV administration, and at 0 (pre-administration), 0.25, 0.5, 0.75, 1, 2, 4, 8, 12, 24 after the first and 5th PO administration. Samples were also taken for serial complete blood count and biochemistry analysis. Prednisolone concentration was determined by high pressure liquid chromatography. Non-compartmental pharmacokinetic parameters were then determined. After IV administration clearance was 347 mL/kg/hr, elimination half-life was 2.98 h, and area under the curve was 2,940 h*ng/mL. After initial and fifth oral administration elimination half-life was 5.27 and 5.39 h; maximum concentration was 74 and 68 ng/mL; time to maximum concentration was 2.67 and 2.33 h; and area under the curve was 713 and 660 hr*ng/mL. Oral bioavailability was determined to be 13.7%. Packed cell volume, hemoglobin, and red blood cell counts were significantly decreased 5 days after the first PO administration, and serum glucose was significantly elevated 5 days after the first PO administration. In conclusion, serum concentrations of prednisolone after IV and PO administration appear to be similar to other veterinary species. Future research will be needed to determine the pharmacodynamics of prednisolone in alpacas.
Architecture of Distributed Control System for Gearbox-Free More Electric Turbofan Engine
Authors: Popov Viktor , Yepifanov Sergiy , Kononykhyn Yevhenii , Tsaglov Aleksandr
Published: October 2021

This article presents the development of the electric turbofan engine in distributed architecture with a design thrust in the range of 3 to 7.5 and from 7.5 to 30 kN for small and medium-sized unmanned aerial vehicles. The engine subsystems are considered as separate smart modules with a built-in control system, exchanging data via a digital channel with the central engine control and diagnostics unit. The key smart engine units are combined in the following subsystems: starter and turbine generators, oil pumps, actuator of guide vanes, fuel pumps, fuel metering unit, control and diagnostic unit. All pumps and guide vane actuator are electrically driven. Control and monitoring signals are transmitted via a digital bus. Functional and reliability analysis and the technical configuration design of each subsystem are presented. Based on analysis of the architecture of distributed control systems for a gearbox-free electric engine, different configurations of described subsystems are proposed.
Triboelectric Nanogenerators for Harvesting Wind Energy: Recent Advances and Future Perspectives
Authors: Li Jiaqi , Chen Jie , Guo Hengyu
Published: October 2021

Throughout the world, wind energy is widely distributed as one of the most universal energy sources in nature, containing a gigantic reserve of renewable and green energy. At present, the main way to capture wind energy is to use an electromagnetic generator (EMG), but this technology has many limitations; notably, energy conversion efficiency is relatively low in irregular environments or when there is only a gentle breeze. A triboelectric nanogenerator (TENG), which is based on the coupling effect of triboelectrification and electrostatic induction, has obvious advantages for mechanical energy conversion in some specific situations. This review focuses on wind energy harvesting by TENG. First, the basic principles of TENG and existing devices’ working modes are introduced. Second, the latest research into wind energy-related TENG is summarized from the perspectives of structure design, self-power sensors and systems. Then, the potential for large-scale application and hybridization with other energy harvesting technologies is discussed. Finally, future trends and remaining challenges are anticipated and proposed.
The Arabidopsis thaliana Kinesin-5 AtKRP125b Is a Processive, Microtubule-Sliding Motor Protein with Putative Plant-Specific Functions
Authors: Strauß Tobias , Schattner Saskia , Hoth Stefan , Walter Wilhelm J.
Published: October 2021

The formation and maintenance of the mitotic spindle during cell division requires several microtubule-interacting motor proteins. Members of the kinesin-5 family play an essential role in the bipolar organization of the spindle. These highly conserved, homotetrameric proteins cross-link anti-parallel microtubules and slide them apart to elongate the spindle during the equal separation of chromosomes. Whereas vertebrate kinesin-5 proteins are well studied, knowledge about the biochemical properties and the function of plant kinesin-5 proteins is still limited. Here, we characterized the properties of AtKRP125b, one of four kinesin-5 proteins in Arabidopsis thaliana. In in vitro motility assays, AtKRP125b displayed the archetypal characteristics of a kinesin-5 protein, a low velocity of about 20 nm·s−1, and a plus end-directed, processive movement. Moreover, AtKRP125b was able to cross-link microtubules and to slide them apart, as required for developing and maintaining the mitotic spindle. In line with such a function, GFP-AtKRP125b fusion proteins were predominantly detected in the nucleus when expressed in Arabidopsis thaliana leaf protoplasts or Nicotiana benthamiana epidermis cells and analyzed by confocal microscopy. However, we also detected GFP signals in the cytoplasm, suggesting additional functions. By generating and analyzing AtKRP125b promoter-reporter lines, we showed that the AtKRP125b promoter was active in the vascular tissue of roots, lateral roots, cotyledons, and true leaves. Remarkably, we could not detect promoter activity in meristematic tissues. Taken together, our biochemical data support a role of AtKRP125b in mitosis, but it may also have additional functions outside the nucleus and during interphase.
Holistic Simulation Approach for Optimal Operation of Smart Integrated Energy Systems under Consideration of Resilience, Economics and Sustainability
Authors: Hoth Kai , Steffen Tom , Wiegel Béla , Youssfi Amine , Babazadeh Davood , Venzke Marcus , Becker Christian , Fischer Kathrin , Turau Volker
Published: October 2021

The intermittent energy supply from distributed resources and the coupling of different energy and application sectors play an important role for future energy systems. Novel operational concepts require the use of widespread and reliable Information and Communication Technology (ICT). This paper presents the approach of a research project that focuses on the development of an innovative operational concept for a Smart Integrated Energy System (SIES), which consists of a physical architecture, ICT and energy management strategies. The cellular approach provides the architecture of the physical system in combination with Transactive Control (TC) as the system’s energy management framework. Independent dynamic models for each component, the physical and digital system, operational management and market are suggested and combined in a newly introduced co-simulation platform to create a holistic model of the integrated energy system. To verify the effectiveness of the operational concept, energy system scenarios are derived and evaluation criteria are suggested which can be employed to evaluate the future system operations.
Influence of Fuel Level on Properties, Productivity, and Mineralogy of Russian Vanadiferous Titanomagnetite Sinter
Authors: Li Jiahao , Men Jingwei , Yang Songtao , Zhou Mi
Published: October 2021

The influence of fuel level on Russian vanadiferous titanomagnetite sinter properties, productivity, and mineralogy are researched by sintering pot testing, metallographic microscopy, scanning electron microscopy analysis, and energy dispersive spectrometer (SEM-EDS) analysis. A comprehensive index is evaluated in conjunction with the same indexes and significance coefficient as that in the Panzhihua Iron and Steel Group. Results show that with the increasing fuel level from 3.5% to 6.0%, flame front speed, yield, tumbling test index (TI), and productivity, all first increase and then decrease. The low temperature reduction degradation index (RDI+3.15) and softening zone (ΔT) gradually increase while the RI and starting temperature of softening (T10), and ending temperature of softening (T40) decrease with increasing fuel levels from 3.5% to 6.0%. With the increase of fuel level from 3.5% to 6.0%, the content of FeO, SiO2, and MgO increase, while TiO2 shows a decrease. For the same increase in fuel level, the number of pores and calcium ferrite and hematite decrease but the silicate increases. In addition, in the fuel level range of 3.5% to 5.5%, magnetite correspondingly increases but then shows a drop after 5.5%. Moreover, when the fuel level increases to greater than 5.0%, FeOx and fayalite quickly increase and a small amount of metallic iron appears under the fuel level of 6.0%. Overall, the optimal fuel level under current production conditions and indicator selection is 4.0%.
Influence of Epoxy Glue Modification on the Adhesion of CFRP Tapes to Concrete Surface
Authors: Szewczak Andrzej
Published: October 2021

Strengthening structural concrete, steel or wooden elements with reinforcement tapes is currently a popular method of extending the durability of buildings. In the glued joint Carbon Fibre Reinforced Polymer (CFRP) tape—concrete substrate, the most critical element is the adhesive layer connecting both materials. The glued joint participates in the transfer of stresses between the reinforced element and the reinforcement tape. Among the numerous analyses of this type of joint, the work resulting from the action of shear stresses (shearing) is considered most frequently, which also results from the originally developed computational models emerging with the development of research on the processes of adhesive effectiveness. The subsequent theories considered the share of other stresses, which is also related to the complex nature of the phenomenon of glue adhesion on various surfaces. Research shows the possibility of modifying the adhesion of the glue by altering its composition and the target surface of application. The study contains the results of research on the possibility of changing the adhesion of the glue to a concrete surface prepared by grinding and sandblasting. The selected epoxy resin has been modified by using the additives of microsilica and carbon nanotubes. Effective mixing of ingredients was achieved due to the use of sonication in the mixing process. Then, the adhesives prepared in this way were used to stick fragments of CFRP tape to concrete surfaces: cleaned, ground and sandblasted. A modified version of the pull-off test was used to determine the effectiveness of adhesion the CFRP tapes to concrete. The results are the final stage summarizing a series of studies including other parameters affecting the bonding efficiency and durability of adhesive bonds.
Wearable Sensor for Assessing Gait and Postural Alterations in Patients with Diabetes: A Scoping Review
Authors: Brognara Lorenzo , Mazzotti Antonio , Di Martino Alberto , Faldini Cesare , Cauli Omar
Published: October 2021

Background and Objectives: Diabetes mellitus is considered a serious public health problem due to its high prevalence and related complications, including gait and posture impairments due to neuropathy and vascular alterations and the subsequent increased risk of falls. The gait of patients with diabetes is characterized by alterations of the main spatiotemporal gait parameters such as gait velocity, cadence, stride time and length, which are also known to worsen with disease course. Wearable sensor systems can be used for gait analysis by providing spatiotemporal parameters and postural control (evaluated from the perspective of body sway), useful for investigating the disease progression. Thanks to their small size and low cost of their components, inertial measurement units (IMUs) are easy to wear and are cheap tools for movement analysis. Materials and Methods: The aim of this study is to review articles published in the last 21 years (from 2000 to 2021) concerning the application of wearable sensors to assess spatiotemporal parameters of gait and body postural alterations in patients with diabetes mellitus. Relevant articles were searched in the Medline database using PubMed, Ovid and Cochrane libraries. Results: One hundred and four articles were initially identified while searching the scientific literature on this topic. Thirteen were selected and analysed in this review. Wearable motion sensors are useful, noninvasive, low-cost, and objective tools for performing gait and posture analysis in diabetic patients. The IMUs can be worn at the lumber levels, tibias or feet, and different spatiotemporal parameters of movement and static posture can be assessed. Conclusions: Future research should focus on standardizing the measurement setup and selecting the most informative spatiotemporal parameters for gait and posture analysis.
Vojta Therapy in Neuromotor Development of Pediatrics Patients with Periventricular Leukomalacia: Case Series
Authors: De-La-Barrera-Aranda Elena , Gonzalez-Gerez Juan Jose , Saavedra-Hernandez Manuel , Fernandez-Bueno Laura , Rodriguez-Blanco Cleofas , Bernal-Utrera Carlos
Published: October 2021

Background and Objectives: Vojta therapy is used by physiotherapists and is based on stimulation through peripheral pressure that leads to the activation of involuntary motor response patterns, thus triggering patterns of reflex locomotion, hence also called reflex locomotion therapy. Objective: To analyze the changes produced by Vojta therapy in the evolution of infant motor development in patients with maturational delay due to periventricular leukomalacia. Materials and methods: One session of Vojta Therapy per week for eleven months, patients’ neuromotor development was evaluated through the Denver II Test and the Baleys Scale. Results: A clinically significant increase in the development of the patients is observed. Conclusions: Neuromotor development seems to generate an adequate progression in the motor area.
Staphylococcal Scalded Skin Syndrome and Bullous Impetigo
Authors: Brazel Morgan , Desai Anand , Are Abhirup , Motaparthi Kiran
Published: October 2021

Staphylococcal scalded skin syndrome (SSSS) and bullous impetigo are infections caused by Staphylococcus aureus. The pathogenesis of both conditions centers around exotoxin mediated cleavage of desmoglein-1, which results in intraepidermal desquamation. Bullous impetigo is due to the local release of these toxins and thus, often presents with localized skin findings, whereas SSSS is from the systemic spread of these toxins, resulting in a more generalized rash and severe presentation. Both conditions are treated with antibiotics that target S. aureus. These conditions can sometimes be confused with other conditions that result in superficial blistering; the distinguishing features are outlined below.
Religion and the Stigma of Suicide: A Quantitative Analysis Using Nationwide Survey Data from Hungary
Authors: Moksony Ferenc , Hegedűs Rita
Published: October 2021

Objective: To examine the effect of religion on negative attitudes and beliefs about suicide. Methods: We use data from a large nationwide survey conducted in Hungary covering more than 3000 individuals. Suicide-related stigmas are captured with three Likert-type measures that we combine into an overall indicator. Religion is measured by denomination (Catholic vs. Protestant) and church attendance (at least weekly vs. never or less than weekly). We employ logistic regression and the SPSS statistical software. Results: People attending religious services frequently have greater odds of stigmatizing self-killing than those reporting no or infrequent attendance. Compared to Protestants, Catholics are significantly less condemning of suicide. The two measures of religion also work in tandem, with denomination modifying the impact of church attendance. In particular, while church attendance strongly increases the odds of negative attitudes among Catholics, it has practically no effect among Protestants. Discussion and Conclusions: The results presented are in keeping with our expectations and suggest that a social climate that stigmatizes suicide without providing for people a strong community network that pressures individuals toward conforming to fundamental moral principles can be especially harmful for mental health.
Artificial Intelligence in Corporate Sustainability: Using LSTM and GRU for Going Concern Prediction
Authors: Chi Der-Jang , Chu Chien-Chou
Published: October 2021

“Going concern” is a professional term in the domain of accounting and auditing. The issuance of appropriate audit opinions by certified public accountants (CPAs) and auditors is critical to companies as a going concern, as misjudgment and/or failure to identify the probability of bankruptcy can cause heavy losses to stakeholders and affect corporate sustainability. In the era of artificial intelligence (AI), deep learning algorithms are widely used by practitioners, and academic research is also gradually embarking on projects in various domains. However, the use of deep learning algorithms in the prediction of going concern remains limited. In contrast to those in the literature, this study uses long short-term memory (LSTM) and gated recurrent unit (GRU) for learning and training, in order to construct effective and highly accurate going-concern prediction models. The sample pool consists of the Taiwan Stock Exchange Corporation (TWSE) and the Taipei Exchange (TPEx) listed companies in 2004–2019, including 86 companies with going concern doubt and 172 companies without going concern doubt. In other words, 258 companies in total are sampled. There are 20 research variables, comprising 16 financial variables and 4 non-financial variables. The results are based on performance indicators such as accuracy, precision, recall/sensitivity, specificity, F1-scores, and Type I and Type II error rates, and both the LSTM and GRU models perform well. As far as accuracy is concerned, the LSTM model reports 96.15% accuracy while GRU shows 94.23% accuracy.
KEANEKARAGAMAN CAPUNG (ODONATA) PADA SAWAH SISTEM ORGANIK DAN KONVENSIONAL DI KABUPATEN PADANG PARIAMAN
Authors: Zulhafandi Zulhafandi
Published: October 2021

ABSTRACTDragonflies are insects important in agricultural ecosystems. Dragonflies have a role as a predator, both in theform of a naiad and adults and feed on certain types of pests on rice plant. The objective of the research was tostudy the diversity of dragonflies (Odonata) in the fields organic and conventional systems of rice in PadangPariaman Regency. A survey was conducted using Purposive sampling survey. Sampleswere collected by usingwater and swinging insect nets. The results showed that the dragonflies (Odonata) found on the site of the researchconsisted of 5 family, 15 species with a total of 354 individuals. Odonata found in organic systems rice fieldsconsisted of 5 family, 15 species and 275 individuals, while the ones in conventional system of rice fields were 3familes, 10 species, 79 individuals. Diversity and equity were higher on the organic system of rice field 2.47 andequity 0.90 respectively, compared with conventional rice field with the value of diversity index of 1.98 and equityindex 0.82.Keywords: Diversity, Dragonflies (Odonata), organic, conventionalABSTRACTCapung merupakan serangga yang penting dalam ekosistem pertanian. Capung memiliki peran sebagai predator,baik dalam bentuk naiad maupun dewasa dan memangsa beberapa jenis hama pada tanamana padi. Penelitian inibertujuan untuk mempelajari keanekaragaman capung (Odonata) pada sawah sistem organik dan konvensional diKabupaten Padang Pariaman. Metode yang digunakan adalah metode survey dengan pengambilan sampelPurposive Random Sampling. Cara pengambilan sampel yaitu dengan menggunakan jaring air dan jaring ayunHasil penelitian menunjukkan bahwa capung (Odonata) yang ditemukan pada lokasi penelitian terdiri dari 5famili, 15 spesies dengan total individu 354. Odonata pada sawah sistem organik 5 famili, 15 spesies, dan 275individu, sedangkan pada sawah konvensional ditemukan 3 famili, 10 spesies dan 79 individu. Keanekaragamandan kemerataan lebih tinggi terdapat pada sawah sistem organik dengan nilai indeks 2,47 dan kemerataan 0,90,dibandingkan dengan sawah konvensional yang memiliki nilai indeks keanekaragaman 1,98 dengan kemerataan0,82Kata kunci : Keanekaragaman, Capung (Odonata), organik, konvensional
Uji Aktivitas Antibakteri Ekstrak Etanol Daun Ketapang (Terminalia catappa L.) Warna Hijau dan Warna Merah serta Kombinasinya
Authors: Munira Munira Munira , Rasidah Rasidah Rasidah , Melani Eva Melani , Zakiah Noni Zakiah , Nasir Muhammad Nasir
Published: October 2021

ABSTRAKDaun ketapang (Terminalia catappa L.) adalah tanaman yang sering dimanfaatkan oleh masyarakat sebagai tanaman obat tradisional. Penelitian ini dilakukan untuk mengetahui pengaruh ekstrak etanol daun ketapang warna hijau, warna merah, kombinasi daun warna hijau dan daun warna merah terhadap pertumbuhan bakteri Staphylococcus aureus. Penelitian ini bersifat eksperimental dengan menggunakan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan yaitu P0 (aquadest sebagai kontrol negatif), P1 (ekstrak etanol daun hijau), P2 (ekstrak etanol daun merah), dan P3 (kombinasi ekstrak etanol daun ketapang berwarna hijau dan merah) dan masing-masing 3 kali ulangan. Uji mikrobiologi menggunakan metode difusi. Berdasarkan hasil uji Anova menunjukkan bahwa ekstrak daun ketapang sangat berpengaruh terhadap pertumbuhan Staphylococcus aureus (P=0,000).Berdasarkan hasil uji lanjut Duncan rata-rata diameter zona hambat yang terbentuk menunjukkan bahwa kombinasi ekstrak daun ketapang warna hijau dan warna merah memiliki zona hambat yang lebih besar (30,92 mm) dan berbeda nyata dengan ekstrak daun ketapang berwarna hijau (21,92 mm), akan tetapi tidak berbeda nyata dengan ekstrak daun ketapang warna merah (26,42 mm).Dari hasil penelitian ini dapat disimpulkan bahwa ekstrak daun ketapang dapat menghambat pertumbuhan bakteri Staphylococcus aureus.Kata kunci: Terminalia catappa L., diameter zona hambat, Staphylococcus aureus Ketapang leaf (Terminalia catappa L.) is a plant that is often used by the community as a traditional medicinal plant. This research was conducted to determine the effect of ethanol extract of green ketapang leaves, red color, combination of green leaf and red leaf color to Staphylococcus aureus bacteria growth. This research was experimental by using Completely Randomized Design (RAL) with 4 treatments which is  P0 (aquadest as negative control), P1 (green leaf ethanol extract), P2 (red leaf ethanol extract), and P3 (combination of green leaf ketapang ethanol extract and red) and each of them repeated 3 times. Microbiology test using diffusion method. Based on the results of Anova test showed that ketapang leaf extract greatly affect the growth of Staphylococcus aureus (P=0.000). Based on the results of further test Duncan average diameter of the inhibition zone that was formed showed that the combination of green leaf and red colored leaf extract has a larger inhibition zone (30.92 mm) and significantly different with green leaf ketapang leaf extract (21.92 mm), but not significantly different with the extract of red leaf ketapang (26.42 mm). From the results of this study can be concluded that ketapang leaf extract can inhibit the growth of Staphylococcus aureus.Keywords: Terminalia catappa L., inhibition zone diameter, Staphylococcus aureus
Evaluasi Kepatuhan Minum Obat Pasien Diabetes Melitus Tipe 2 Di Fasilitas Kesehatan Tingkat Pertama UPTD Puskesmas Ungaran Dan UPTD Puskesmas Ambarawa Dengan Intervensi Pemberian Home Pharmacy Care
Authors: Hati Anita Kumala , Karminingtyas Sikni Retno , Devi Dita Arisca , Damai Wati Brian Resti
Published: October 2021

Diabetes Melitus merupakan penyakit kronis dengan pengobatan jangka panjang yang memerlukan kepatuhan. Salah satu intervensi yang komprehensif untuk penyakit DM adalah home pharmacy care untuk meningkatkan kepatuhan pasien. Kepatuhan minum obat pasien Diabetes Melitus yang dilihat dari parameter Modified Morisky’s Adherence Scale (MMAS-8), Gula Darah Puasa (GDP) dan pill count. Penelitian ini bertujuan melihat hasil intervensi Home Pharmacy care terhadap kepatuhan minum obat pasien Diabetes Mellitus tipe 2 di UPTD Puskesmas Ungaran dan UPTD Puskesmas Ambarawa pada periode Mei hingga Juni 2018.  Hasil penelitian dengan uji T berpasangan ditinjau dari MMAS-8 didapatkan p value 0,118 pada kelompok kontrol dan 0,000 pada kelompok perlakuan. Sedangkans ditinjau dari GDP didapatkan p value 0,223 pada kelompok kontrol dan 0,000 kelompok perlakuan. Dan dengan uji T tidak berpasangan berdasarkan pill count didapatkan p value 0,000. Maka dapat disimpulkan pemberian home pharmacy care dapat meningkatkan kepatuhan minum obat pasien DM tipe II di UPTD Puskeskmas Ungaran dan UPTD Puskesmas Ambarawa.Kata Kunci : Home pharmacy care, Diabetes Melitus Tipe 2, Kepatuhan.Diabetes Melitus is a chronic disease with long-term treatment that requires adherences. One of the most comprehensive interventions for DM patients is Home Pharmacy Care, that can monitor patient compliance. The study aims to determine the effect of Home Pharmacy Care DM against medication adherence which is seen from the parameter of Modified Morisky’s Adherence Scale (MMAS-8), blood glucose (GDP)  and pill count. This research was a quasi experimentpretest-posttest with control group design, the study conducted in Ungaran and Ambarawa public health center from May to Jun 2018. The sampling method was accidental sampling technique. Samples obtained were 62 people and divided into 2 groups of control group (31 people) and treatment group (31 people). The result of paired t-test indicated that p value of control group reviewed by MMAS-8 was 0,118 and treatment group was 0,000. Based p value glucose blood (GDP) of control group was 0,223 and  treatment group was 0,000. The result of independentt-test by p value of the pill count was 0,000. Home Pharmacy Care can improve medication adherence to Diabetes Melitus Type II patientsat the  Ambarawa public health center. Keywords  : Home pharmacy care, Diabetes Melitus Type 2, Adherence.
Skrining Fitokimia Dan Analisis Kromatografi Lapis Tipis Ekstrak Etanol Kulit Buah Naga Merah (Hylocereus polyrhizus)
Authors: Jawa La Elisabeth Oriana , Sawiji Repining Tiyas , Yuliawati Agustina Nila
Published: October 2021

Buah naga merah (Hylocereus polyrhizus) merupakan tumbuhan yang sudah banyak dimanfaatkan oleh masyarakat Indonesia secara alami sebagai tanaman kaya antioksidan, sebaliknya pemanfaatan dari kulit buah naga merah belum sepenuhnya dimaksimalkan. Beberapa penelitian yang telah dilakukan menunjukkan bahwa selain daging buah, kulit buah naga merah dapat dimanfaatkan sebagai sumber untuk pengobatan karena kaya akan antioksidan. Hal tersebut dapat digunakan sebagai dasar dan pilihan untuk menghasilkan produk obat tradisional dari kulit buah naga merah. Penelitian ini bertujuan untuk mengidentifikasi kandungan metabolit sekunder yang terdapat pada kulit buah naga merah berupa skrining fitokimia dan kromatografi lapis tipis (KLT) pada senyawa aktif yang disinyalir terkandung didalam kulit buah naga merah yang dapat dimanfaatkan dalam produk kefarmasian. Ekstraksi dilakukan dengan cara maserasi menggunakan pelarut etanol 96% diperoleh rendemen ekstrak sebanyak 2,96%. Skrining fitokimia dilakukan sebagai uji pendahuluan untuk mengidentifikasi kandungan metabolit sekunder yang terkandung dalam ekstrak kulit buah naga merah, dilanjutkan dengan KLT untuk mempertegas hasil reaksi positif. Hasil skrining dan KLT diperoleh kulit buah naga merah positif mengandung alkaloid, tanin, flavonoid, steroid dan potensial untuk dijadikan obat tradisional.Kata kunci :kulit buah naga merah, skrining fitokimia, KLT, metabolit sekunder Red dragon fruits (Hylocereus polyrhizus) generally has been widely known Indonesian as a plant that rich in antioxidant  however, the Red dragon fruits peel is not fully utilized. Some of studies have been conducted indicating that as well as its fruit flesh, Red dragon fruits peel can be beneficial as a source for treatment and traditional medicinal products since it is also rich of antioxidants.This research aims to identify the content of secondary metabolites on the Red dragon fruits peel  in the form of phytochemical screening and thin-layer chromatography (TLC) in the active compounds which can be utilized in the product of  Pharmacy. Extraction is conducted by maceration using the 96% ethanol solvent in order to produces extracts as much as 2.96 %.  Phytochemical screening is delivered as a preliminary test to identify the content of secondary metabolites contained in the peel of  Red dragon fruit peel and continued with the TLC to confirmed give positive  results. Results of  the screening and TLC obtained that the peel of  Red dragon fruits positive contains alkaloids, tannins, flavonoids, steroids and potential to be used as traditional medicineKeyword : Red dragon fruit peel, phytochemical screening, TLC, secondary metabolites
THE RELATIONSHIP BETWEEN WORKPLACE BULLYING AND JOB SATISFACTION IN OMAN’S HOTEL SECTOR: THE MEDIATING ROLE OF OCCUPATIONAL SELF-EFFICACY
Authors: Al Hashimi Asma Shughail Aqib , Azmin Adi Anuar
Published: October 2021

An inclusive workplace helps in achieving effective performance at all organisational levels. Workplace bullying is recognised as a global phenomenon tremendously influencing self-efficacy and employees’ job satisfaction. The current study aimed to examine the relationship between workplace bullying and job satisfaction with the mediating role of occupational self-efficacy in the hotel sector in Oman. The cross-sectional research was carried out in three hotels in Oman. The data were collected from 400 employees working in middle and low management in hotels in Oman. Additionally, data were gathered using the Negative Acts Questionnaire-Revised, the Occupational Self-Efficacy Scale, and the Generic Job Satisfaction Scale. Preliminary data analysis and regression analysis were performed using Statistical Package for Social Science (SPSS). Meditational analysis was conducted with PROCESS macro written by Hayes. The findings highlighted that workplace bullying correlates with job satisfaction positively and negatively with occupational self-efficacy. Occupational self-efficacy was negatively correlated with job satisfaction. Regression analysis showed that workplace bullying was a significant predictor of job satisfaction. However, occupational self-efficacy did not significantly mediate the relationship between workplace bullying and job satisfaction. The mediational analysis confirmed that occupational self-efficacy did not mediate the relationship between workplace bullying and job satisfaction. Management must develop and concentrate on building an inclusive work environment to reduce workplace bullying and harness occupational self-efficacy. Practical steps must be taken to deliver the interventions that can empower the employee to tackle workplace bullying and improves self-efficacy. This study also identified limitations and future research options.
HOUSEBOAT SERVICES AND ITS FEATURES AS A TOURIST ATTRACTION IN TASIK KENYIR, TERENGGANU
Authors: Mapjabil Jabil , Abdul Rashid Nurul Fatehah , Marzuki Mazdi , Yusoh Mohamad Pirdaus , Stephen Jeannet , Datu Eranza Datu Razali , Kanyo Nor-Ina , Andin Christina , Mohd Salleh Noorziah , M.Z. Rosmiza
Published: October 2021

Houseboats are one of the tourist attractions in Tasik Kenyir, Terengganu. Their unique services have not been documented much which prompted this study. The objectives of this study are (i) to identify the features of houseboats as tourist attractions in Tasik Kenyir, and (ii) to examine the characteristics of services offered by houseboat operators to tourists visiting the lake. The design of this study is exploratory and the approach used is qualitative through in-depth interviews supported by observation. Eight houseboat operators and workers were involved in the study as informants. The results showed that the features of houseboats are unique in that they have complete facilities like those found in a house. Among the facilities provided are a living room, bedrooms, kitchen area, toilet/bathroom, barbeque area, and provision of safety jackets. The services include the types of packages, rental price, booking mode, and duration of booking including houseboat services payment method. In summary, the fundamental study of houseboats as a tourist attraction in Tasik Kenyir is relevant for the purpose of documentation and as a reference to various parties such as tourism policymakers, houseboat operators and researchers.
Contribution of social and demographic parameters to the long-term survival prognosis of chronic myeloid leukemia patients
Authors: Kulikov S. M. , Lazareva O. V. , Turkina A. G. , Kulikovsky A. A. , Pospelova T. I. , Kutsev S. I. , Zaritzkey A. Yu. , Shatokhin Yu. V. , Konstantinova T. S. , Parovichnikova E. N. , Savchenko V. G.
Published: October 2021

Introduction. Therapy of chronic myeloid leukemia (CML) for the majority of patients is associated with continuous lifelong drug intake. Irregular drug intake greatly increases the risk of CML progression and death. It is still not well understood to what extent social and demographic factors infl uence the long-term consequences of CML therapy.

Aim — to determine the prognostic value of social parameters like marital status and education level in comparison with standard risk factors for the course of the disease.

Materials and methods. A multifactorial data analysis of the presented sociodemographic parameters was carried out on a cohort of CML patients included in the multicenter observational study “Russian Registry for the Treatment of Chronic Myeloid Leukemia in Routine Clinical Practice”. The database of the study conducted in Russia in 2011–2016 includes records of 12160 patients with CML. To analyze the register data, we used classical methods of event analysis implemented in the SAS 9.4 package.

Results. A large volume of data with a high level of signifi cance showed that educational level and marital status have a great prognostic value in assessing the long-term results of therapy in patients with CML, comparable to known risk factors. The contribution of these signs was evaluated and analyzed taking into account such known factors as age, ELTS index, and region or clinic where the patient was observed and treated. Thus, low educational qualifi cations and marital status “divorced” or “widowed” demonstrated signifi cant and independent risk factors that negatively affect the life expectancy of patients with CML Conclusion. The discovered phenomenon is key in long-term survival and can be explained by the indirect infl uence of social-demographic parameters through adherence behavior of CML patients. Higher level of education proved to be a favorable factor while a widowed/divorced marital status was found to be an unfavorable factor of OS prognosis. General clinic, age related interpretations, and regional features were also tested and did not fi nd any confi rmation.
Nauczanie online w kontekście postępu edukacyjnego i terapeutycznego dziecka ze specyficznymi trudnościami w uczeniu się
Authors: Maj Elżbieta A. , Maj Natalia
Published: October 2021

CEL NAUKOWY: Praca poddaje refleksji formy prowadzenia zajęć lekcyjnych po zmianie metodyki na nauczanie zdalne, jak również obrazuje możliwości postępu – zarówno edukacyjnego, jak i terapeutycznego – dzieci ze specyficznymi trudnościami w uczeniu się. PROBLEM I METODY BADAWCZE: Wiodącym problemem badawczym jest pytanie o korelat „covidowych” modeli funkcjonowania oświaty ze specyfiką objawową oraz terapeutyczną dysleksji. Biorąc pod uwagę interdyscyplinarność problemu leżącego na zbiegu pedagogiki i prawa, do badań pedagogicznych zastosowano metodę monograficzną, a do prawnych – metodę dogmatycznoprawną. PROCES WYWODU: Publikację rozpoczyna opis zaburzenia dysleksji i jego skutków w sferze społecznej i oświatowej. Następnie analizie poddano prawne podstawy funkcjonowania placówek oświatowych w warunkach tradycyjnych oraz reżimu pandemicznego (SARS-CoV-2). WYNIKI ANALIZY NAUKOWEJ: Z przeprowadzonych badań wynika, że okres pandemii, który wymusił system nauczania zdalnego, przekłada się na ograniczone możliwości terapeutyczne wobec uczniów z zaburzeniem dysleksji oraz niemal całkowicie wyeliminował możliwość wczesnej diagnozy nauczycielskiej. WNIOSKI, INNOWACJE, REKOMENDACJE: Pandemia koronawirusa pozostawia niezaprzeczalny ślad na procesie edukacyjnym uczniów szkół podstawowych, zwłaszcza uczniów ze specyficznymi trudnościami w uczeniu się. Obszarem, który uległ zdecydowanemu zaniedbaniu ze względu na pozbawienie nauczycieli możliwości bezpośredniego kontaktu ze swoimi uczniami, jest obszar wczesnej diagnozy oraz profilaktyki występowania zaburzeń rozwojowych oraz trudności w uczeniu się.
The The Daily Life of Contemporary Mothers – Between Social Expectations, the Sense of Duty and the Individual Experience of Motherhood
Authors: Lewicka Monika
Published: October 2021

RESEARCH OBJECTIVE: The aim of this paper is to present the dilemmas of everyday life of contemporary mothers related to society’s expectations of motherhood and their individual experiences. THE RESEARCH PROBLEM AND METHODS: The research problem was the (re)construction of everyday life of modern mothers during a pandemic. The narrative interview technique was used in the research. THE PROCESS OF ARGUMENTATION: This article analyzes how mothers experience motherhood during a pandemic against the background of social transformations. The issue of everyday life as an important category was presented in the considerations contained in the article below. Then, the methodological assumptions and research results focused on the issues of the multiplicity of choices in the present day and the difficulties associated with them, as well as the everyday life of mothers, were presented. The article ends with reflections on the situation of mothers in the context of contemporary challenges. RESEARCH RESULTS: A conclusion can be drawn about the positioning of motherhood between the traditional and modern pattern of the ideal mother. First of all, mothers feel tired of the seriousness of the role they play, and from fulfilling which many people can “hold them accountable”. CONCLUSIONS, INNOVATIONS, AND RECOMMENDATIONS: The conducted research shows interesting conclusions pointing to changes related to the perception of the role of the mother in modern times. They contribute to the undertaking of more extensive research on the need for (re) construction of motherhood.
Porozwodowe porozumienia rodzicielskie – analiza prawnoporównawcza
Authors: Prucnal-Wójcik Marta
Published: October 2021

CEL NAUKOWY: Celem artykułu jest przedstawienie analizy porównawczej unormowań prawnych wybranych krajów europejskich regulujących kwestie dotyczące możliwości zawierania przez rodziców porozumień dotyczących sposobu realizacji władzy rodzicielskiej po rozwodzie względem ich małoletnich dzieci. PROBLEM I METODY BADAWCZE: Przedstawiony problem badawczy dotyczy odpowiedzi na pytania: Czy rozwodzący się rodzice mogą zawierać między sobą porozumienia dotyczące sposobu realizacji władzy rodzicielskiej po rozwodzie względem ich małoletnich dzieci? A jeśli tak, czy porozumienia te podlegają kontroli właściwego organu? Poszukując odpowiedzi na powyższe pytania, autor zastosował metodę analizy adekwatnych przepisów prawnych wybranych krajów europejskich. PROCES WYWODU: Analizując przepisy obowiązujące w ustawodawstwie wewnętrznym wybranych państw europejskich (Polska, Austria, Norwegia, Szwecja, Węgry) autor przedstawił przyjęte rozwiązania prawne regulujące kwestie związane z zakresem władzy rodzicielskiej rodziców po orzeczeniu rozwodu, w tym te odnoszące się do możliwości zawierania przez rodziców porozumień dotyczących sposobu realizacji władzy rodzicielskiej po rozwodzie. WYNIKI ANALIZY NAUKOWEJ: Ustawodawstwo każdego z pięciu omówionych państw dopuszcza możliwość zawierania przez rodziców porozumień dotyczących sposobu realizacji władzy rodzicielskiej po rozwodzie. W Polsce, Austrii, Szwecji i na Węgrzech porozumienie rodzicielskie dla swojej ważności wymaga zatwierdzenia przez sąd. WNIOSKI, INNOWACJE, REKOMENDACJE: Ze względu na wymogi redakcyjne dotyczące objętości artykułu autor ograniczył analizę regulacji prawnych do ustawodawstw wybranych pięciu krajów europejskich. W dalszej perspektywie zasadna i interesująca wydaje się analiza rozwiązań prawnych obowiązujących w innych krajach tak europejskich, jak i tych spoza naszego kręgu kulturowego.
Prawo dziecka do relacji osobistej z rodzicami w sytuacji ich rozstania
Authors: Pawlak Anna
Published: October 2021

CEL NAUKOWY: Celem opracowania jest analiza sytuacji dziecka w relacji osobistej z rodzicem w czasie kryzysu w rodzinie, jakim jest rozstanie rodziców, uwzględniając obowiązujące przepisy prawa polskiego. PROBLEM I METODY BADAWCZE: Problemem do rozwiązania stała się odpowiedź na pytanie, czy obowiązujące przepisy w sposób właściwy określają prawo do relacji osobistych dziecka z rodzicami żyjącymi w rozłączeniu. W zakresie przyjętej metodologii zastosowano założenia filozofii antropologicznej, filozofii personalistycznej, filozofii dialogu, praw człowieka i filozofii odpowiedzialności, a także metodę dogmatyczno-prawną oraz metodę analizy i krytyki piśmiennictwa. PROCES WYWODU: Opracowanie rozpoczyna zwrócenie uwagi na problem relacji osobistej dziecka z rodzicami po ich rozstaniu. Następnie dokonano analizy art. 113 § 1 Kodeksu rodzinnego i opiekuńczego w kontekście prawidłowości ujmowania relacji z rodzicem jako obowiązku dziecka, a także prawidłowości ograniczenia regulacji sfery stosunków z rodzicami po ich rozstaniu do kontaktów. Wskazano także na sposób, w jaki regulacje międzynarodowe określają relacje dziecka z rodzicami żyjącymi w separacji. WYNIKI ANALIZY NAUKOWEJ: Podjęte badania wskazują na konieczność dostosowania polskich regulacji do standardów międzynarodowych i pełniejsze uwzględnienie podmiotowości i godności osobowej dziecka. WNIOSKI, INNOWACJE, REKOMENDACJE: Postuluje się zmianę regulacji art. 113 § 1 Kodeksu rodzinnego i opiekuńczego poprzez usunięcie kategorii obowiązku dziecka do kontaktu z rodzicem oraz zmianę pojęcia kontakt na szerszą definicję osobistych relacji.
Edytorial: Opieka i wychowanie w czasach kryzysu
Authors: Prucnal-Wójcik Marta
Published: October 2021

Opieka i wychowanie stanowią nieodłączne formy aktywności każdego człowieka, a szczególnie tego, który realizuje swoje życiowe powołanie w rodzinie. O opiece mówimy najczęściej w relacji rodzic – dziecko, dziecko – rodzic, opiekun – podopieczny, lekarz – pacjent. Opieka niejednokrotnie powiązana jest z wychowaniem.
KAJIAN EMISI CO2 BERDASARKAN JEJAK KARBON SEKUNDER DI LINGKUNGAN UNIVERSITAS SAHID JAKARTA
Authors:   Program Studi Teknik Lingkungan, Fakultas Teknik, Universitas Sahid Jakarta, Febrina Laila , Harki Refsiela ,   Program Studi Teknik Lingkungan, Fakultas Teknik, Universitas Sahid Jakarta
Published: October 2021

Perubahan iklim terjadi akibat adanya peningkatan konsentrasi emisi gas rumah kaca, dimana emisi karbon dioksida (CO2) adalah kompenen utama gas rumah kaca. Emisi CO2terbesar dari sektor energi yaitu penggunaan energilistrik yang berasal dari aktivitas dalam gedung. Penelitian ini bertujuan untuk mengkaji emisi CO2yang dihasilkan dari penggunaan listrik di Universitas Sahid Jakarta. Pengumpulan data dilakukan dengan menghitung pemakaian daya listrik dari ACdan lampudan komputer yang terdapat di Gedung Utama Universitas Sahid Jakarta . Perhitungan emisi CO2diperoleh dari perkalian penggunaan energi listrik peralatan elektronik dengan faktor emisi sesuai dengan ketentuan Surat Direktur Jenderal Ketenagalistrikan, Kementerian Energi dan Sumber Daya Mineral (ESDM). Hasil yang diperoleh dari perhitungan diketahui bahwa penggunaan listrik di Gedung Utama Universitas Sahid Jakarta rata-rata menggunakan daya listrik sebesar 601.142,4 kWh/tahun dan mengeluarkan emisi sebesar498.948,192 kgCO2per tahun. Untuk mengurangi dampak pemanasan global dari penggunaan listrik, Universitas Sahid Jakarta dapat melakukan gerakan efesiensi energi listrik dengan mengurangi penggunaan AC sebagai penyejuk ruangan dengan memperbanyakventilasi atau lubang udara sebagai tempat pengaliran udara. Melakukan kegiatan penghijauan. Penggunaan lampu sebagai pencahayaan pada ruangan juga dapat diganti dengan lampu yang berdaya lebih kecil, yang dibantu dengan memperbanyak pencahayaan alami dari sinar matahari yang masuk ke dalam ruangan
UJI KANDUNGAN PARAMETER KIMIA AIR TANAH DI SEKITAR TEMPAT PENAMPUNGAN SEMENTARA UNTUK KEBUTUHAN AIR BERSIH DI(STUDI KASUS: TPS PERUMAHAN X)
Authors:   Program Studi Teknik Lingkungan, Fakultas Teknik, Universitas Sahid Jakarta, Qibtia Almira , Maharani Maya ,   Program Studi Teknik Lingkungan, Fakultas Teknik, Universitas Sahid Jakarta, Noviana Linda ,   Program Studi Teknik Lingkungan, Fakultas Teknik, Universitas Sahid Jakarta
Published: October 2021

Sumber air untuk keperluan higiene sanitasi harus terjaga dari kontaminasi luar, salah satunya dari lokasi Tempat Penampungan Sementara Sampah (TPS). Masyarakat di Perumahan X menggunakan air tanah sebagai sumber utama kebutuhan air bersih namun di sekitar perumahan terdapat TPS dengan kondisi yang tidak memadai. Penelitian ini bertujuan untuk mengetahui kualitas kimiawi air tanah untuk kebutuhan air bersih warga dan mengetahui pemetaan kualitas air tanah di Perumahan X. Contoh air sumur diambil di 6 titik di radius <250 m dari lokasi TPS dan 12 titik di radius >250 m secara acak. Hasil uji parameter pH, logam Fe, Mn dan Zn, kesadahan, dan nitrat dibandingkan dengan PERMENKES No. 32 Tahun 2017 sementara pemetaan dilakukan dengan menggunakan software berbasis GIS. Hasil penelitian menunjukkan bahwa air tanah di radius <250 m dan >250 m dari TPS tidak memenuhi baku mutu untuk persyaratan pH. Selanjutnya, parameter Fe, Mn, Zn, kesadahan dan nitrat dalam air tanah memenuhi baku mutu untuk semua sampel, kualitas air dikatakan baik. Sebaran parameter kesadahan dan nitrat tidak mutlak dipengaruhi jarak dari lokasi TPS. Pada peta sebaran kadar pH logam, sampel di radius >250 m memiliki kadar yang lebih rendah dan kualitas air lebih baik dibandingkan dengan sampel di jarak <250 m.
PEMBUATAN ADSORBEN DARI SEKAM PADI SEBAGAI PENYERAP LOGAM BERAT TEMBAGA (Cu) DAN TIMBAL (Pb) DALAM AIR LIMBAH
Authors:   Program Studi Teknik Kimia, Fakultas Sains dan Teknologi, Institut Sains dan Teknologi Al-Kamal, Halim Abdul , Romadon Jamalaily ,   Program Studi Teknik Kimia, Fakultas Sains dan Teknologi, Institut Sains dan Teknologi Al-Kamal, Achyar Mustafa ,   Program Studi Teknik Kimia, Fakultas Sains dan Teknologi, Institut Sains dan Teknologi Al-Kamal
Published: October 2021

Seiring dengan perkembangan industri yang semakin bertambah, maka semakin banyak pula limbah yang dihasilkan (hasil sampingan yang diproduksi sebagai limbah). Beberapa metode kimia maupun biologis telah dicoba untuk menghilangkan logam berat yang terdapat di dalam limbah, diantaranya adsorpsi. Salah satu adsorben dari alam yang menjanjikan untuk dimanfaatkan adalah sekam padi. Tahapan awal yang dilakukan adalah membuat karbon aktif dari sekam padi. Karbon yang telah teraktivasi ditimbang dengan variasi massa yaitu 0.5 g, 1 g dan 2 g kemudian dimasukkan kedalam 100 ml sampel air limbah yang telah diketahui konsentrasi Tembaga (Cu) dan Timbalnya (Pb). Kemudian campuran diaduk dengan menggunakan magnetic stirrer selama variasi waktu pengadukan 30, 60, 90, 120, 150 dan 180 menit. Adsorpsi optimum ion logam Cu dan Pb pada air limbah diperoleh pada massa adsorben 2 g waktu pengadukan 180 menit dengan efisiensi penyerapan masing-masing 98,63% dan 99,39% dan kapasitas adsorpsinya yaitu 0,3205 mg/g dan 0,1377 mg/g.