bluuebunny/crossref_metadata_2025 huggingface dataset:
Double Colonization: A Voice of the Voiceless in Leila Abouzeid's Year of the Elephant
Authors: Rashed Redhwan Qasem Ghaleb
Published: March 2022

Many Afro-Arab women novelists, if not all, have been addressing feminist issues for ages while homeland issues have been masculinized. Against this trend, Leila Abouzeid's academic interests span not only women's issues, but also those of men and of her country as well. Her book shows how a woman is dominated by patriarchy and colonization and how she herself appears to be an executioner. It also shows her struggle and resistance against patriarchy and imperial power, without sacrificing her commitment to her national and religious identity. In contrast to secular feminism, Abouzeid views religion as a source of relief and solace. The study also argues that the men happily adopt the colonial culture whereas their women resist it. Tackling the experience of double colonization in Year of the Elephant captures the experiences of millions of women in both the eastern and western hemispheres who rebel over the laws that govern their lives.
Invasive slipper limpetsCrepidula fornicataare hosts for sterilizing digenean parasites
Authors: Quinn Emma A. , Thomas Jessica E. , Malkin Sophie H. , Eley Molly-Jane , Coates Christopher J. , Rowley Andrew F.
Published: March 2022

Invasion and spread of alien species can drive ecosystem changes, such as, the dynamics of infectious diseases. The non-native, marine gastropodCrepidula fornicatahas become established across European coastlines over the last century, but there remains little insight into its disease carrying capacity and potential role as a source/sink of parasites. To address this knowledge gap, we surveyed limpets from two sites in South Wales, UK for signatures of disease/pathology using polymerase chain reaction-based methods (haemolymph) and histology (solid tissue). We encountered trematode-like parasites in ~1% individuals (5 out of 462). Three limpets displayed gross damage in the gonad, i.e. castration, and encysted metacercariae were found in the muscle of two other individuals. On the basis of 28S rDNA and internal transcribed spacer 2 genomic targets, we identified the gonad-infecting trematodes as members of the family Microphallidae – putative novel species related to the genusLongiductotrema. Earlier reports suggest thatC. fornicatais not a host for trematode parasites in either its native or alien range but may act as a sink due to its filter feeding lifestyle. We provide clear evidence thatC. fornicatais parasitized by at least one trematode species at two sites in Wales, UK, and likely act as a spillback or accidental host among native littorinids.
Adapting to children’s individual language proficiency: An observational study of preschool teacher talk addressing monolinguals and children learning English as an additional language
Authors: CHAN Kin Chung Jacky , MONAGHAN Padraic , MICHEL Marije
Published: March 2022

In an increasingly diverse society, young children are likely to speak different first languages that are not the majority language of society. Preschool might be one of the first and few environments where they experience the majority language. The present study investigated how preschool teachers communicate with monolingual English preschoolers and preschoolers learning English as an additional language (EAL). We recorded and transcribed four hours of naturalistic preschool classroom activities and observed whether and how preschool teachers tailored their speech to children of different language proficiency levels and linguistic backgrounds (monolingual English: n = 13; EAL: n = 10), using a suite of tools for analysing quantity and quality of speech. We found that teachers used more diverse vocabulary and more complex syntax with the monolingual children and children who were more proficient in English, showing sensitivity to individual children’s language capabilities and adapting their language use accordingly.
Introduction to the Project for Strengthening the ASEAN Regional Capacity on Disaster Health Management (ARCH Project)
Authors: Ikeda Shuichi , Silapunt Phumin
Published: March 2022

Background:

Southeast Asia is the second biggest region in the world in terms of the total number of natural disasters since 1900. Therefore, the Association of Southeast Asian Nations (ASEAN) initiated regional challenges toward strengthening regional collaboration for disaster prevention and response since the earthquake of Sumatra in Indonesia occurred in 2004. Moreover, ASEAN Leaders signed “the ASEAN Declaration on One ASEAN, One Response” in 2016. Under these circumstances, ASEAN decided to implement the Project for Strengthening the ASEAN Regional Capacity on Disaster Health Management (ARCH Project).

Objectives:

The objective of the ARCH Project is to strengthen coordination on disaster health management (DHM) for rapid and effective response to disasters occurring in the ASEAN region and to enhance the capacity of each ASEAN Member State (AMS) on DHM. This article aims to overview the outline and its strategy, and review the progress of the project.

Methods:

ARCH Project is an ASEAN official project supported by Japan’s official development assistance. Five outputs were launched for: (1) coordination platform on DHM; (2) framework of regional collaboration practices; (3) tools for effective regional collaboration; (4) enhancement of academic network on DHM; and (5) capacity development activities for each AMS. The Project was reviewed in terms of accomplishment and evaluation criteria.

Results:

Regional Coordination Committee on DHM was established as a coordination platform to: Oversee the implementation of the ARCH Project for the Output 1; Regional Collaboration Drill was developed and conducted for the Output 2; The standard operating procedure for coordination of emergency medical teams (EMTs) in ASEAN was developed for the Output 3; Various presentations on ARCH were made in academic conferences for the Output 4; and Several training programs and educational curricula were developed for the Output 5. The Project has accomplished its Project Purpose and satisfied all the indicators set. ARCH Project has high Relevance, Impact, Sustainability, and Effectiveness, while some improvements in Efficiency are needed.

Conclusions:

ARCH Project is the first-ever successful regional cooperation mechanism and standardization of DHM in ASEAN, one of the most disaster-prone regions. It also contributes to the capacity building of AMS. The ARCH Project has a remarkable impact on the resilience and flexible medical response to disasters, although continuous efforts of stakeholders to make this initiative sustainable are necessary.
Social Cognition in Temporal and Frontal Lobe Epilepsy: Systematic Review, Meta-analysis, and Clinical Recommendations
Authors: Ziaei Maryam , Arnold Charlotte , Thompson Kate , Reutens David C.
Published: March 2022

Objective:

Despite the importance of social cognitive functions to mental health and social adjustment, examination of these functions is absent in routine assessment of epilepsy patients. Thus, this review aims to provide a comprehensive overview of the literature on four major aspects of social cognition among temporal and frontal lobe epilepsy, which is a critical step toward designing new interventions.

Method:

Papers from 1990 to 2021 were reviewed and examined for inclusion in this study. After the deduplication process, a systematic review and meta-analysis of 44 and 40 articles, respectively, involving 113 people with frontal lobe epilepsy and 1482 people with temporal lobe epilepsy were conducted.

Results:

Our results indicated that while patients with frontal or temporal lobe epilepsy have difficulties in all aspects of social cognition relative to nonclinical controls, the effect sizes were larger for theory of mind (g = .95), than for emotion recognition (g = .69) among temporal lobe epilepsy group. The frontal lobe epilepsy group exhibited significantly greater impairment in emotion recognition compared to temporal lobe. Additionally, people with right temporal lobe epilepsy (g =  1.10) performed more poorly than those with a left-sided (g = .90) seizure focus, specifically in the theory of mind domain.

Conclusions:

These data point to a potentially important difference in the severity of deficits within the emotion recognition and theory of mind abilities depending on the laterlization of seizure side. We also suggest a guide for the assessment of impairments in social cognition that can be integrated into multidisciplinary clinical evaluation for people with epilepsy
Cross-linguistic influence during online sentence processing in bilingual children
Authors: van Dijk Chantal , Dijkstra Ton , Unsworth Sharon
Published: March 2022

To assess the presence of cross-linguistic influence, this study compared the processing of Dutch sentences by English–Dutch and German–Dutch bilingual and Dutch monolingual children in a self-paced listening task. We combined insights from studies on child bilingualism and adult second language acquisition. Sentence structures showing partial overlap between languages were investigated (long passives), as well as structures with complete or no overlap (verb second and verb third sentences). We found evidence for syntactic co-activation of overlapping structures in the form of inhibition during listening. Syntactic, and possibly lexical, overlap between languages, and language dominance modulated effects. In particular, online cross-linguistic influence was visible only in the German–Dutch group. Furthermore, effects were most pronounced when structures partially overlapped and were absent in non-overlapping structures. Effects of online cross-linguistic influence became stronger the more German-dominant children were. Our results indicate that syntactic co-activation across languages affects sentence processing in bilingual children.
Fungal plant pathogens observed on perennial cereal crops in New York during 2017–2018
Authors: Fulcher Michael R. , Law Eugene P. , Wayman Sandra , Ryan Matthew R. , Bergstrom Gary C.
Published: March 2022

Perennial grain crops are emerging as a promising addition to sustainable agricultural systems because of their low-input requirements and delivery of ecosystem services. However, adoption of these crops is expected to bring novel management challenges, including those related to plant diseases. In New York, fungal pathogens of annual grains have a significant impact on crop yield and value and are generally controlled through a combination of host resistances, cultural practices and chemical fungicides. Without the availability of crop rotation and soil tillage practices, disease control in perennial grain systems may be problematic, and little is known about perennial grain crop susceptibility to local plant pathogen populations. During 2017 and 2018, ongoing field trials of two perennial grain crops recently introduced in New York, intermediate wheatgrass (IWG; Thinopyrum intermedium) and perennial cereal rye (PCR; Secale cereale), were assessed for the presence of putative fungal pathogens on actively growing plants, overwintered crop residue and harvested grain. A total of nine potential host–pathogen combinations were recorded based on symptomology, pathogen morphology and DNA sequences. Common annual crop pathogens were recovered most frequently, but, at one site, Phyllachora graminis, causal fungus of tar spot and a pathogen not previously reported on crops in New York, was found on IWG. Residue colonization by an important toxigenic pathogen (Fusarium graminearum) was high in both crops, though mycotoxin levels in associated grain were low, indicating either the hosts or environment were unsuitable for disease development. Seed-borne fungal communities differed across crops and locations, and black point, a condition caused by Alternaria and Bipolaris fungi and indicative of compromised grain quality, was prevalent in PCR under some conditions. Growing PCR with intercropped red clover (Trifolium pratense L.) resulted in less Stagonospora colonization of stem residue, and PCR grown with an oat (Avena sativa L.) nurse crop had a reduced incidence of black point. These alternative cultural practices may prove useful for managing disease in perennial grains. Our results suggest that the incorporation of perennial crops into the agricultural landscape will lead to familiar plant disease problems requiring new solutions as well as new problems that may require significant research investments.
A novel modified circular ring-based broadband polarization-insensitive angular stable circuit analog absorber (CAA) for RCS applications
Authors: Shukoor Mohammad Abdul , Dey Sukomal
Published: March 2022

In this study, a compact modified circular ring-based circuit analog absorber (CAA) is proposed. It comprises a resistor-loaded frequency selective surface (FSS) underneath an FR-4 substrate, and the other end is terminated with a perfect electric conductor (PEC) separated by an air-spacer. The proposed design shows a minimum −10 dB reflectance from 10.55 to 36.03 GHz (25.48 GHz bandwidth and 109.4% fractional bandwidth) with two dips at 13.5 GHz and 35.23 GHz having reflectivity −17.18 dB and −24.9 dB, respectively. The existing four-fold circular symmetry architecture shows insensitivity for different polarization angles under normal incidences and up to 45° stability for Transverse Electric (TE) and Transverse Magnetic (TM) modes under oblique incidences. The proposed cell is compact with a periodicity of 0.193λL, and a thickness of 0.09λL, where λL is the free-space wavelength corresponding to the lowest frequency of the absorption band. The novelty of the design lies in the topology of using an underneath FSS to take advantage of effective permittivity control for both broader bandwidth and better angular stability. To demonstrate the ability of the proposed design, a 28 GHz microstrip patch antenna prototype is fabricated, and its radar cross section (RCS) is measured after loading with the absorber. A 15.15 dBsm RCS reduction is observed in comparison with the PEC. The authors strongly believe that the proposed design has potential applications such as RCS reduction and radio-frequency energy harvesting.
Novel measurement technique to detect breast tumor based on the smallest form factor of UWB patch antenna
Authors: Zerrad Fatima-Ezzahra , Taouzari Mohamed , Makroum El Mostafa , Aoufi Jamal , Nasraoui Hanane , Aksoy Fadima Gülsever , Karaaslan Muharrem , Islam Md Tarikul
Published: March 2022

A small ultra-wideband (UWB) patch antenna for microwave breast imaging (MWI) applications is shown off in this paper. However, to improve the antenna performance relating to the bandwidth (BW), the radiating element of the suggested antenna is modified by adding slits in the patch as well as the ground plane. The proposed prototype has a relatively small size of 20 × 19 × 1.6 mm3and it accomplishes a return loss below −10 dB (S11< −10 dB) at an overall BW of 7 GHz (4–11 GHz) with more than 3 dBi realized gain. The antenna is designed and simulated by using a finite integration technique-based simulator. In this way, the characteristics of the fabricated antenna are measured to examine the antenna performance. Indeed, the fidelity factor of face-to-face (FtF) and side-by-side (SbS) scenarios are also noticed for the same frequency range. In the final analysis, a simulation model of the antennas, that operate as a transceiver, and a breast phantom model with tumor sample is proposed for detecting cancerous tumor cells within the breast. Hence, the proposed approach is suitable for UWB based MWI applications in tumor cell detection.
Trends in Downwelling Longwave Radiance Over the Southern Great Plains
Authors: Liu Lei , Huang Yi , Gyakum John R. , Turner David D. , Gero P. Jonathan
Published: March 2022

Downwelling longwave radiation is an important part of the surface energy budget. Spectral trends in the downwelling longwave radiance (DLR) provide insight into the radiative drivers of climate change. In this research, we process and analyze a 23‐year DLR record measured by the Atmospheric Emitted Radiance Interferometer (AERI) at the U.S. Department of Energy Atmospheric Radiation Program Southern Great Plains (SGP) site. Two AERIs were deployed at SGP with an overlapping observation period of about 10 years, which allows us to examine the consistency and accuracy of the measurements and to account for discrepancies between them due to errors associated with the instruments themselves. We then analyzed the all‐sky radiance trends in DLR, which are associated with the surface warming trend at SGP during this same period and also the complex changes in meteorological conditions. For instance, the observed radiance in the CO2 absorption band follows closely the near‐surface air temperature variations. The significant positive radiance trends in weak absorption channels, such as in the wings of the CO2 band and in the weak absorption channels in the H2O vibration‐rotational band, show earlier detectability of climate change. The magnitude of the radiance trend uncertainty in the DLR record mainly results from internal climate variability rather than from measurement error, which highlights the importance of continuing the DLR spectral measurements to unambiguously detect and attribute climate change.
3D Modeling of Geomagnetically Induced Currents in Sweden—Validation and Extreme Event Analysis
Authors: Rosenqvist L. , Fristedt T. , Dimmock A. P. , Davidsson P. , Fridström R. , Hall J. O. , Hesslow L. , Kjäll J. , Smirnov M. Yu , Welling D. , Wintoft P.
Published: March 2022

Rosenqvist and Hall (2019), https://agupubs.onlinelibrary.wiley.com/doi/abs/10.1029/2018SW002084 developed a proof‐of‐concept modeling capability that incorporates a detailed 3D structure of Earth's electrical conductivity in a geomagnetically induced current estimation procedure (GIC‐SMAP). The model was verified based on GIC measurements in northern Sweden. The study showed that southern Sweden is exposed to stronger electric fields due to a combined effect of low crustal conductivity and the influence of the surrounding coast. This study aims at further verifying the model in this region. GIC measurements on a power line at the west coast of southern Sweden are utilized. The location of the transmission line was selected to include coast effects at the ocean‐land interface to investigate the importance of using 3D induction modeling methods. The model is used to quantify the hazard of severe GICs in this particular transmission line by using historic recordings of strong geomagnetic disturbances. To quantify a worst‐case scenario GICs are calculated from modeled magnetic disturbances by the Space Weather Modeling Framework based on estimates for an idealized extreme interplanetary coronal mass ejection. The observed and estimated GIC based on the 3D GIC‐SMAP procedure in the transmission line in southern Sweden are in good agreement. In contrast, 1D methods underestimate GICs by about 50%. The estimated GICs in the studied transmission line exceed 100 A for one of 14 historical geomagnetic storm intervals. The peak GIC during the sudden impulse phase of a “perfect” storm exceeds 300 A but depends on the locality of the station as the interplanetary magnetic cloud hits Earth.
Incorporating the Effect of Gravity Into Image‐Based Drainage Simulations on Volumetric Images of Porous Media
Authors: Chadwick Eric A. , Hammen Lucas H. , Schulz Volker P. , Bazylak Aimy , Ioannidis Marios A. , Gostick Jeff T.
Published: March 2022

Simulating drainage in volumetric images of porous materials is a key technique for studying multiphase flow and transport. Image‐based techniques based on sphere insertion are popular due to their computational efficiency and reasonable predictions, though they lack physical rigor. Since most tomograms are small, the impact of gravity on the fluid distributions has not been previously considered. With the advent of stochastically generated images of arbitrary size, and ever larger field‐of‐view images, the validity of neglecting gravity is becoming questionable. In this work, an image‐based technique that includes the effect of gravity during gravity stabilized displacements was developed and validated. Results compared favorably with analytical solutions of capillary rise in tubes, and to micromodel experiments in terms of the pseudo‐capillary pressure curves. The compactness of the invasion front was also shown to vary linearly with the inverse Bond number. Finally, a contour map of expected error as a function of image size and Bond number was generated to help identify when gravitational effects cannot be ignored. The presented algorithm utilizes only basic image processing tools and offers the same computational advantage as other image‐based sphere insertion methods.
Tree-rings reveal two strong solar proton events in 7176 and 5259 BCE
Authors: Brehm Nicolas , Christl Marcus , Knowles Timothy D. J. , Casanova Emmanuelle , Evershed Richard P. , Adolphi Florian , Muscheler Raimund , Synal Hans-Arno , Mekhaldi Florian , Paleari Chiara I. , Leuschner Hanns-Hubert , Bayliss Alex , Nicolussi Kurt , Pichler Thomas , Schlüchter Christian , Pearson Charlotte L. , Salzer Matthew W. , Fonti Patrick , Nievergelt Daniel , Hantemirov Rashit , Brown David M. , Usoskin Ilya , Wacker Lukas
Published: March 2022

The Sun sporadically produces eruptive events leading to intense fluxes of solar energetic particles (SEPs) that dramatically disrupt the near-Earth radiation environment. Such events have been directly studied for the last decades but little is known about the occurrence and magnitude of rare, extreme SEP events. Presently, a few events that produced measurable signals in cosmogenic radionuclides such as 14C, 10Be and 36Cl have been found. Analyzing annual 14C concentrations in tree-rings from Switzerland, Germany, Ireland, Russia, and the USA we discovered two spikes in atmospheric 14C occurring in 7176 and 5259 BCE. The ~2% increases of atmospheric 14C recorded for both events exceed all previously known 14C peaks but after correction for the geomagnetic field, they are comparable to the largest event of this type discovered so far at 775 CE. These strong events serve as accurate time markers for the synchronization with floating tree-ring and ice core records and provide critical information on the previous occurrence of extreme solar events which may threaten modern infrastructure.
Causal connectivity from right DLPFC to IPL in schizophrenia patients: a pilot study
Authors: Ćurčić-Blake Branislava , Kos Claire , Aleman André
Published: March 2022

Abnormal function and connectivity of the fronto-parietal network (FPN) have been documented in patients with schizophrenia, but studies are correlational. We applied repetitive transcranial magnetic stimulation (rTMS) to the dorso-lateral prefrontal cortex (DLPFC) and observed causal connectivity to the inferior parietal lobe (IPL). We hypothesized that patients with schizophrenia would have lower activation and slower reaction in the IPL following DLPFC stimulation. Thirteen patients with schizophrenia (SZ) and fourteen healthy controls subjects (HC) underwent rTMS at 10 Hz to the right DLPFC. Simultaneously, we measured brain activation in the IPL, represented as oxygenized hemoglobin (HbO) levels, using functional near-infrared spectroscopy (fNIRS). rTMS consisted of 20 trains of impulses at 10 Hz for 3 seconds, and 60 seconds waiting time. Using NIRSLab software, GLM was applied to estimate both hemodynamic response function (HRF) and its derivative. Following TMS to the DLPFC, SZ showed a smaller decrease in HbO levels in the bilateral IPL than HC (p = 0.05). Timecourse analysis revealed an immediate decrease in parietal HbO levels in HC, but not in SZ. This difference was significant (at a threshold level of p ≤ 0.05, with Bonferroni correction) for several time segments and channels in both rights and left IPL. Our findings suggest abnormal fronto-temporal connectivity in patients with schizophrenia, beyond a mere decrease or slowing of information processing. This is in line with the hypothesis of reduced fronto-parietal inhibition in schizophrenia.
Recognizing the groundwater related to chronic kidney disease of unknown etiology by humic-like organic matter
Authors: Zeng Xianjiang , He Wei , Guo Huaming , Shi Qiutong , Zheng Yaxin , Vithanage Meththika , Hur Jin
Published: March 2022

Chronic kidney disease of unknown etiology (CKDu) becomes a health concern in developing countries. It is urgent to recognize CKDu-related groundwater in CKDu-prevalent areas. Here, spectral indices showed that DOM from CKDu groundwater was characterized by higher molecular weight, stronger exogenous feature, and greater degree of humification and unsaturation than from non-CKDu groundwater. Parallel factor analysis of fluorescence spectra showed that DOM from CKDu groundwater contained significantly more humic-like substances (C1%) and less protein-like substances than from non-CKDu groundwater. Furthermore, C1% was correlated with concentrations of inorganic chemicals associated with CKDu, indicating the feasibility of using C1% for probing CKDu groundwater. According to our self-developed method, both the non-CKDu probability of groundwater with C1% less than the recognizing threshold (RT, 28.8%) and the CKDu probability of groundwater with C1% larger than RT are 70.1%. This indicates that the C1%-based method is a feasible tool for recognizing CKDu groundwater.
Field validation of the performance of paper-based tests for the detection of the Zika and chikungunya viruses in serum samples
Authors: Karlikow Margot , da Silva Severino Jefferson Ribeiro , Guo Yuxiu , Cicek Seray , Krokovsky Larissa , Homme Paige , Xiong Yilin , Xu Talia , Calderón-Peláez Maria-Angelica , Camacho-Ortega Sigrid , Ma Duo , de Magalhães Jurandy Júnior Ferraz , Souza Bárbara Nayane Rosário Fernandes , de Albuquerque Cabral Diego Guerra , Jaenes Katariina , Sutyrina Polina , Ferrante Tom , Benitez Andrea Denisse , Nipaz Victoria , Ponce Patricio , Rackus Darius G. , Collins James J. , Paiva Marcelo , Castellanos Jaime E. , Cevallos Varsovia , Green Alexander A. , Ayres Constância , Pena Lindomar , Pardee Keith
Published: March 2022

In low-resource settings, resilience to infectious disease outbreaks can be hindered by limited access to diagnostic tests. Here we report the results of double-blinded studies of the performance of paper-based diagnostic tests for the Zika and chikungunya viruses in a field setting in Latin America. The tests involved a cell-free expression system relying on isothermal amplification and toehold-switch reactions, a purpose-built portable reader and onboard software for computer vision-enabled image analysis. In patients suspected of infection, the accuracies and sensitivities of the tests for the Zika and chikungunya viruses were, respectively, 98.5% (95% confidence interval, 96.2–99.6%, 268 serum samples) and 98.5% (95% confidence interval, 91.7–100%, 65 serum samples) and approximately 2 aM and 5 fM (both concentrations are within clinically relevant ranges). The analytical specificities and sensitivities of the tests for cultured samples of the viruses were equivalent to those of the real-time quantitative PCR. Cell-free synthetic biology tools and companion hardware can provide de-centralized, high-capacity and low-cost diagnostics for use in low-resource settings.
Meta-analyses of fifteen determinants of public opinion about climate change taxes and laws
Authors: Bergquist Magnus , Nilsson Andreas , Harring Niklas , Jagers Sverker C.
Published: March 2022

Public acceptance is a precondition for implementing taxes and laws aimed at mitigating climate change. However, it still remains challenging to understand its determinants for the climate community. Here, we use a meta-analytic approach to examine the role of public opinion about climate change taxes and laws. Fifteen variables were examined by synthesizing 89 datasets from 51 articles across 33 countries, with a total sample of 119,465 participants. Among all factors, perceived fairness and effectiveness were the most important determinants. Self-enhancement values and knowledge about climate change showed weak relationships and demographic variables showed only weak or close to zero effects. Our meta-analytic results provide useful insights and have the potential to inform climate change researchers, practitioners and policymakers to better design climate policy instruments.
SARS-CoV-2 is associated with changes in brain structure in UK Biobank
Authors: Douaud Gwenaëlle , Lee Soojin , Alfaro-Almagro Fidel , Arthofer Christoph , Wang Chaoyue , McCarthy Paul , Lange Frederik , Andersson Jesper L. R. , Griffanti Ludovica , Duff Eugene , Jbabdi Saad , Taschler Bernd , Keating Peter , Winkler Anderson M. , Collins Rory , Matthews Paul M. , Allen Naomi , Miller Karla L. , Nichols Thomas E. , Smith Stephen M.
Published: March 2022

There is strong evidence of brain-related abnormalities in COVID-191–13. However, it remains unknown whether the impact of SARS-CoV-2 infection can be detected in milder cases, and whether this can reveal possible mechanisms contributing to brain pathology. Here we investigated brain changes in 785 participants of UK Biobank (aged 51–81 years) who were imaged twice using magnetic resonance imaging, including 401 cases who tested positive for infection with SARS-CoV-2 between their two scans—with 141 days on average separating their diagnosis and the second scan—as well as 384 controls. The availability of pre-infection imaging data reduces the likelihood of pre-existing risk factors being misinterpreted as disease effects. We identified significant longitudinal effects when comparing the two groups, including (1) a greater reduction in grey matter thickness and tissue contrast in the orbitofrontal cortex and parahippocampal gyrus; (2) greater changes in markers of tissue damage in regions that are functionally connected to the primary olfactory cortex; and (3) a greater reduction in global brain size in the SARS-CoV-2 cases. The participants who were infected with SARS-CoV-2 also showed on average a greater cognitive decline between the two time points. Importantly, these imaging and cognitive longitudinal effects were still observed after excluding the 15 patients who had been hospitalised. These mainly limbic brain imaging results may be the in vivo hallmarks of a degenerative spread of the disease through olfactory pathways, of neuroinflammatory events, or of the loss of sensory input due to anosmia. Whether this deleterious effect can be partially reversed, or whether these effects will persist in the long term, remains to be investigated with additional follow-up.
Extracellular vesicle neurofilament light is elevated within the first 12-months following traumatic brain injury in a U.S military population
Authors: Guedes Vivian A. , Lange Rael T. , Lippa Sara M. , Lai Chen , Greer Kisha , Mithani Sara , Devoto Christina , A. Edwards Katie , Wagner Chelsea L. , Martin Carina A. , Driscoll Angela E. , Wright Megan M. , Gillow Kelly C. , Baschenis Samantha M. , Brickell Tracey A. , French Louis M. , Gill Jessica M.
Published: March 2022

Traumatic brain injury (TBI) can be associated with long-term neurobehavioral symptoms. Here, we examined levels of neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in extracellular vesicles isolated from blood, and their relationship with TBI severity and neurobehavioral symptom reporting. Participants were 218 service members and veterans who sustained uncomplicated mild TBIs (mTBI, n = 107); complicated mild, moderate, or severe TBIs (smcTBI, n = 66); or Injured controls (IC, orthopedic injury without TBI, n = 45). Within one year after injury, but not after, NfL was higher in the smcTBI group than mTBI (p = 0.001, d = 0.66) and IC (p = 0.001, d = 0.35) groups, which remained after controlling for demographics and injury characteristics. NfL also discriminated the smcTBI group from IC (AUC:77.5%, p < 0.001) and mTBI (AUC:76.1%, p < 0.001) groups. No other group differences were observed for NfL or GFAP at either timepoint. NfL correlated with post-concussion symptoms (rs = − 0.38, p = 0.04) in the mTBI group, and with PTSD symptoms in mTBI (rs = − 0.43, p = 0.021) and smcTBI groups (rs = − 0.40, p = 0.024) within one year after injury, which was not confirmed in regression models. Our results suggest the potential of NfL, a protein previously linked to axonal damage, as a diagnostic biomarker that distinguishes TBI severity within the first year after injury.
Machine learning algorithm as a sustainable tool for dissolved oxygen prediction: a case study of Feitsui Reservoir, Taiwan
Authors: Ziyad Sami Balahaha Fadi , Latif Sarmad Dashti , Ahmed Ali Najah , Chow Ming Fai , Murti Muhammad Ary , Suhendi Asep , Ziyad Sami Balahaha Hadi , Wong Jee Khai , Birima Ahmed H. , El-Shafie Ahmed
Published: March 2022

Water quality status in terms of one crucial parameter such as dissolved oxygen (D.O.) has been an important concern in the Fei-Tsui reservoir for decades since it’s the primary water source for Taipei City. Therefore, this study aims to develop a reliable prediction model to predict D.O. in the Fei-Tsui reservoir for better water quality monitoring. The proposed model is an artificial neural network (ANN) with one hidden layer. Twenty-nine years of water quality data have been used to validate the accuracy of the proposed model. A different number of neurons have been investigated to optimize the model's accuracy. Statistical indices have been used to examine the reliability of the model. In addition to that, sensitivity analysis has been carried out to investigate the model's sensitivity to the input parameters. The results revealed the proposed model capable of capturing the dissolved oxygen's nonlinearity with an acceptable level of accuracy where the R-squared value was equal to 0.98. The optimum number of neurons was found to be equal to 15-neuron. Sensitivity analysis shows that the model can predict D.O. where four input parameters have been included as input where the d-factor value was equal to 0.010. This main achievement and finding will significantly impact the water quality status in reservoirs. Having such a simple and accurate model embedded in IoT devices to monitor and predict water quality parameters in real-time would ease the decision-makers and managers to control the pollution risk and support their decisions to improve water quality in reservoirs.
Chronic wounds treated with cold atmospheric plasmajet versus best practice wound dressings: a multicenter, randomized, non-inferiority trial
Authors: Strohal R. , Dietrich S. , Mittlböck M. , Hämmerle G.
Published: March 2022

The use of phase-adapted wound dressings represents best practice (BP) in chronic wound treatment. However, efficacy is often limited and associated care requirements are high. Cold atmospheric plasmajet (CAP-jet) is a promising new therapeutic tool for these wounds. In the present multicenter, randomized, open-label, prospective, clinical trial, non-inferiority of the CAP-jet versus BP was assessed in 78 patients with infected or non-infected chronic wounds of different etiology. Primary outcome measure was the sum of granulation tissue, furthermore wound area reduction, healing rate, time to complete healing, changes in wound pH value, infection score, exudate level and local tolerability were assessed. In CAP-jet treated wounds compared to control, the sum of granulation tissue was significantly higher (p < 0.0001) and wound area reduced significantly faster (p < 0.001). Furthermore, wound pH value decreased significantly faster (p = 0.0123) and local infection was overcome more rapidly by CAP-jet therapy. In 58.97% CAP-jet- vs. 5.13% BP-treated patients, complete healing of chronic ulcers was documented after 6 weeks. Treatment with CAP-jet appeared not only non-inferior, but even superior to BP in all wound entities analyzed with a favorable tolerability profile. Thus, treatment with the CAP-jet provides beneficial effects in chronic wound treatment regarding promotion of the wound healing process.
Structured pathways in the turbulence organizing recent oil spill events in the Eastern Mediterranean
Authors: García-Sánchez Guillermo , Mancho Ana M. , Ramos Antonio G. , Coca Josep , Wiggins Stephen
Published: March 2022

The chaotic nature of ocean motion is a major challenge that hinders the discovery of spatio-temporal current routes that govern the transport of material. Certain material, such as oil spills, pose significant environmental threats and these are enhanced by the fact that they evolve in a chaotic sea, in a way which still nowadays is far from being systematically anticipated. Recently such an oil spill event has affected the Mediterranean coast of several Middle Eastern countries. No accidents were reported for these spills previous to their arrival at the coast, and therefore there was no hint of their origin. Modelling such an event, in which uncertainties are increased due to the lack of information on where and when the spills was produced, stretches available technologies to their limits, and requires the use of novel ideas that help to understand the essential features of oil and tar transport by ocean currents. In this regard Lagrangian Coherent Structures enable us to find order within ocean chaos and provide powerful insights into chaotic events and their relationships over different locations and times like the one addressed. Using the observed locations of the oil impacting the coast at specific times, we seek to determine its original location and the time it was released in the open ocean. We have determined both using a combination of earlier satellite observations and computational modelling of the time evolution. The observed agreement between modeled cases and satellite observations highlights the power of these ideas.
Ultrasound-guided needle positioning for nodal dynamic contrast-enhanced MR lymphangiography
Authors: Wagenpfeil J. , Kupczyk P. A. , Henkel A. , Geiger S. , Köster T. , Luetkens J. A. , Schild H. H. , Attenberger U. I. , Pieper C. C.
Published: March 2022

The aim of the study was to assess injection needle positioning for contrast-enhanced MR-lymphangiography (MRL) by ultrasound-guided injection of saline-solution. 80 patients (33 male, mean age 43.1 years) were referred for MRL. The injection needle position was assessed by injection of saline-solution. Consecutive lymph node distension was observed on sonography followed by MRL. Transpedal MRL was performed when no inguinal lymph nodes could be identified. The inguinal lymph node detection rate was recorded. MR-lymphangiograms were assessed regarding primary (i.e. enhancement of draining lymph vessels) and secondary technical success (i.e. lymph vessel enhancement after repositioning of the needle). MRL was considered as clinically successful if enhancement of the central lymphatic system and/or a lymphatic pathologies were observed. For a total of 92 MRLs 177 groins were evaluated sonographically. In 171/177 groins (96.6%) lymph nodes were identified. After needle placement lymph node distension was observed in 171/171 cases (100%) on saline injection. MR-contrast injection demonstrated enhancement of draining lymph vessels in 163/171 cases (95.3%). In 6/171 cases (3.5%) in-bore needle retraction lead to lymphatic enhancement. In one patient [2/171 nodes (1.1%)] no lymphatic enhancement was seen despite repeated needle repositioning. Overall contrast application was technically successful in 169/171 cases (98.8%). In the 6 groins in which no nodes were identifiable, transpedal MRL was successful. So overall 91/92 MRLs (98.9%) were clinically successful. No complications were recorded. Confirmation of the needle position for nodal MRL by sonographically controlled saline injection is a reliable technique with a high success rate of MRL.
Influence of cerebral microbleeds on mechanical thrombectomy outcomes
Authors: Lee Seong-Joon , Hwang Yang-Ha , Hong Ji Man , Choi Jin Wook , Park Ji Hyun , Park Bumhee , Kang Dong-Hun , Kim Yong-Won , Kim Yong-Sun , Hong Jeong-Ho , Yoo Joonsang , Kim Chang-Hyun , Sohn Sung-Il , Lee Jin Soo
Published: March 2022

In ischemic stroke patients undergoing endovascular treatment (EVT), we aimed to test the hypothesis that cerebral microbleeds (CMBs) are associated with clinical outcomes, while estimating the mediating effects of hemorrhagic transformation (HT), small-vessel disease burden (white matter hyperintensities, WMH), and procedural success. From a multicenter EVT registry, patients who underwent pretreatment MR imaging were analyzed. They were trichotomized according to presence of CMBs (none vs. 1–4 vs. ≥ 5). The association between CMB burden and 3-month mRS was evaluated using multivariable ordinal logistic regression, and mediation analyses were conducted to estimate percent mediation. Of 577 patients, CMBs were present in 91 (15.8%); 67 (11.6%) had 1–4 CMBs, and 24 (4.2%) had ≥ 5. Increases in CMBs were associated with hemorrhagic complications (β = 0.27 [0.06–0.047], p = 0.010) in multivariable analysis. The CMB effect on outcome was partially mediated by post-procedural HT degree (percent mediation, 14% [0–42]), WMH (23% [7–57]) and lower rates of successful reperfusion (6% [0–25]). In conclusion, the influence of CMBs on clinical outcomes is mediated by small-vessel disease burden, post-procedural HT, and lower reperfusion rates, listed in order of percent mediation size.
Optimization of methods for the accurate characterization of whole blood neutrophils
Authors: Connelly Ashley N. , Huijbregts Richard P. H. , Pal Harish C. , Kuznetsova Valeriya , Davis Marcus D. , Ong Krystle L. , Fay Christian X. , Greene Morgan E. , Overton Edgar T. , Hel Zdenek
Published: March 2022

Neutrophils are the most abundant circulating leukocyte population with critical roles in immune defense, regulation of innate and adaptive immune systems, and disease pathogenesis. Our progress in understanding precise mechanisms of neutrophil activation, recruitment, and function has been hampered by the lack of optimized and standardized methods for the characterization and phenotyping of this readily activated population. By comparing eight methods of neutrophil characterization, we demonstrate that the level of neutrophil activation and degranulation is associated with specific experimental conditions and the number and type of manipulation steps employed. Staining whole blood at 4 °C and removal of remaining unbound antibodies prior to one-step fixation and red blood cell lysis minimizes neutrophil activation, decreases phenotypic alterations during processing, and prevents nonspecific antibody binding. The effects of anticoagulants used for collection, processing delays, and time and temperature during sample analysis on neutrophil phenotype are addressed. The presented data provide a foundation for higher quality standards of neutrophil characterization improving consistency and reproducibility among studies.
Massive transformation in FeNi nanopowders with nanotwin-assisted nitridation
Authors: Wang Jian , Hirayama Yusuke , Liu Zheng , Suzuki Kazuyuki , Yamaguchi Wataru , Park Kwangjae , Takagi Kenta , Kura Hiroaki , Watanabe Eiji , Ozaki Kimihiro
Published: March 2022

L10-ordered FeNi alloy (tetrataenite), a promising candidate for rare-earth-free and low-cost permanent magnet applications, is attracting increasing attention from academic and industrial communities. Highly ordered single-phase L10-FeNi is difficult to synthesis efficiently because of its low chemical order–disorder transition temperature (200–320 °C). A non-equilibrium synthetic route utilizing a nitrogen topotactic reaction has been considered a valid approach, although the phase transformation mechanism is currently unknown. Herein, we investigated the basis of this reaction, namely the formation mechanism of the tetragonal FeNiN precursor phase during the nitridation of FeNi nanopowders. Detailed microstructure analysis revealed that the FeNiN precursor phase could preferentially nucleate at the nanotwinned region during nitridation and subsequently grow following a massive transformation, with high-index irrational orientation relationships and ledgewise growth motion detected at the migrating phase interface. This is the first report of a massive phase transformation detected in an Fe–Ni–N system and provides new insights into the phase transformation during the nitriding process. This work is expected to promote the synthetic optimization of fully ordered FeNi alloys for various magnetic applications.
Spatial occurrence and sources of PAHs in sediments drive the ecological and health risk of Taihu Lake in China
Authors: Lang Xiulu , He Xinghua , Wang Yanhua , Chen Xi , Zhang Mingli , Zhao Zihan , Sun Tian
Published: March 2022

To study the spatial occurrence, sources, and ecological risks of 16 PAHs, surface sediments had been collected from seven major areas of Taihu Lake, China in April 2021. Results showed that the concentrations of ∑16PAHs varied between 1381.48 and 4682.16 ng g−1, and the contents of BghiP in each sample were the highest. The PAHs concentrations in the sediments near the lakeshore were much higher than those in the central area of the lake. The sedimentary ∑16PAHs were mainly composed of molecular-weight monomers and 4-ring PAHs showed superiority (35.69–45.02%). According to the ratio of PAH monomer, the sedimentary PAHs in Taihu Lake were dominantly derived from the combustion. Through the biological toxicity assessment and the BaP equivalent (BaPE), great biological risks of PAHs monomers i.e. DahA and IcdP were found. Both concentrations of ∑16PAHs and dominant 4–6-ring monomers accompanied by carcinogenic risks in many areas of Taihu Lake increased. It is necessary to strengthen monitoring and take measures to control the input of organic pollutants.
Vegetation increases abundances of ground and canopy arthropods in Mediterranean vineyards
Authors: Blaise Chloé , Mazzia Christophe , Bischoff Armin , Millon Alexandre , Ponel Philippe , Blight Olivier
Published: March 2022

The decline of arthropod populations observed in many parts of the world is a major component of the sixth mass extinction with intensive agriculture being one of its main drivers. Biodiversity-friendly farming practices are taking centre stage in the recovery process. In vineyards, vegetation cover is commonly used for production purposes, to reduce soil compaction by machinery use and soil erosion. Here we examined the effects of vegetation cover and soil management on the abundance of ground- (spiders, beetles, Hemiptera and harvestmen) and canopy-dwelling (wild bees, green lacewings, beetles and Hemiptera) arthropods in three categories of vineyards: (i) vineyards with no vegetation, (ii) partially vegetated (every second inter-row is vegetated) and (iii) all inter-rows are vegetated. We recorded a general positive effect of a decrease in soil perturbation intensity and corresponding higher vegetation cover on arthropod abundance. Plant species richness was the most important vegetation parameter, with a positive effect on spiders, harvestmen, hemipterans and beetles (ground and canopy) abundances. Using a path analysis, we also highlighted the central role of inter-row vegetation management in trophic and non-trophic relationships between vegetation and arthropods, and between arthropod groups. Our results demonstrate the benefits of a softer soil management preserving a diverse vegetation cover for the conservation of arthropods in Mediterranean vineyards.