bluuebunny/crossref_metadata_2025 huggingface dataset:
Good Practices for Health Technology Assessment Guideline Development: A Report of the Health Technology Assessment International, HTAsiaLink, and ISPOR Special Task Force
Authors: Botwright Siobhan , Sittimart Manit , Chavarina Kinanti Khansa , Bayani Diana Beatriz Samson , Merlin Tracy , Surgey Gavin , Suharlim Christian , Espinoza Manuel A. , Culyer Anthony J. , Oortwijn Wija , Teerawattananon Yot
Published: January 2025

Objectives

Health technology assessment (HTA) guidelines are intended to support the successful implementation of HTA by enhancing consistency and transparency in concepts, methods, processes, and use, thereby enhancing the legitimacy of the decision-making process. This report lays out good practices and practical recommendations for developing or updating HTA guidelines to ensure successful implementation.

Methods

The task force was established in 2022 and comprised experts and academics from various geographical regions, each with substantial experience in developing HTA guidelines for national health policy making. Literature reviews and key informant interviews were conducted to inform these good practices. Stakeholder consultations, open peer reviews, and expert opinions validated the recommendations. A series of teleconferences among task force members was held to iteratively refine the report.

Results

The recommendations cover six key aspects throughout the guideline development cycle: (1) setting objectives, scope, and principles of the guideline, (2) building a team for a quality guideline, (3) defining a stakeholder engagement plan, (4) developing content and utilizing available resources, (5) putting in place appropriate institutional arrangements, and (6) monitoring and evaluating guideline success.

Conclusion

This report presents a set of resources and context-appropriate practices for developing or updating HTA guidelines. Across all contexts, the recommendations emphasize transparency, building trust among stakeholders, and fostering a culture of ongoing learning and improvement. The report recommends timing development and revision of guidelines according to the HTA landscape and pace of HTA institutionalization. Because HTA is increasingly used to inform different kinds of decision making in a variety of country contexts, it will be important to continue to monitor lessons learned to ensure the recommendations remain relevant and effective.
Surge of human astrovirus type 1 infection in summer 2022 in Korea
Authors: Lee Su-Kyung , Jeon You La , Cho Eun-Jung , Kim Han-Sung , Kim Jae-Seok , Song Wonkeun , Kim Hyun Soo
Published: January 2025

As astroviral infection rapidly increased in the summer of 2022 in Korea, this study aimed to determine the cause and genotype of astroviruses during this period. From January to December 2022, we tested 43,312 stool samples from patients with acute gastroenteritis utilizing multiplex PCR to detect HAstV. For the HAstV-positive samples, we determined the genotypes of the HAstVs by PCR and sequencing. The monthly positive rate from 2015 to 2022 showed a notable and abrupt increase of HAstV infection between June and August 2022, peaking at 9.8% in July 2022. The annual positivity rate of HAstV remained at 2–3% between 2015 and 2019, and then decreased to 0.5% in 2020, followed by an increase to 1.5% in 2021 and 3.6% in 2022.The genotyped astroviruses in 2022 were all identified as HAstV-1 type, and the nucleotide identity% among them was >99%. The GenBank accession number for the strain genetically closest to the strains identified in our study was ON571597.1, which was HAstV-1 isolated from Pingtan in 2019. Our results provide recent epidemiological data on HAstVs in Korea. The decline and surge in astrovirus positivity in recent years may be related to the COVID-19 pandemic.
Both Sides, Now: A Personal Stroke Recovery Journey
Authors: Gillett Grant
Published: January 2025

This is a personal narrative of my stroke and recovery experience, and the medical, psychological, and social circumstances surrounding it.
Effects of maternal liver abnormality on in vitro maturation of bovine oocytes
Authors: Ashibe Shiori , Kobayashi Yui , Toishikawa Shusuke , Nagao Yoshikazu
Published: January 2025

In cattle, maternal metabolic health has been suggested to influence oocyte and embryo quality. Here, we examined whether maternal liver abnormalities affected in vitro oocyte maturation by screening meiotic maturation, spindle morphology, actin filaments, and lysosomes. In oocytes from the abnormal liver group, the maturation rate (80.2%) was significantly lower compared to a control group with healthy livers (90.8%; P < 0.05). Mean spindle area in oocytes of the abnormal group (50.4 ± 3.4 μm2) was significantly larger than in the control (40.8 ± 1.6 μm2; P < 0.05). Likewise, mean spindle width in the abnormal group (8.8 ± 0.3 μm) was significantly larger than in the control group (7.8 ± 0.2 μm; P < 0.05). The proportion of cells with correctly aligned chromosomes in the abnormal group (48.0%) was significantly lower than in the control (78.3%; P < 0.05). The number of cortical actin filaments in mature oocytes of the abnormal group (299.3 ± 3.7) was significantly lower than in the control (314.7 ± 3.2; P < 0.05). The number of lysosomes in mature oocytes of the abnormal group (1363.6 ± 39.0) was significantly higher than in the control (1123.4 ± 26.3; P < 0.05). In conclusion, our findings indicate that the quality of in vitro matured oocytes is lower in cattle with liver abnormalities than in healthy cattle.
The effect of consecutive ejaculation on the sperm parameters in the oligo-astheno-teratozoospermia (OAT) men
Authors: Hosseini Akram , Borzouie Zahra , Khalili Parvin , Vatanparast Mahboubeh
Published: January 2025

Recently, the World Health Organization recommendation for abstinence time for semen analysis has been challenged in some studies and many of them have supported the advantages of a second short abstinence ejaculation. More evidence is needed to approve this for clinical use. This study aimed to compare the average routine abstinence time (2–7 days) with the short time (1–2 h) on sperm quality based on functional parameters in a population of oligo-astheno-teratozoospermia (OAT) men. The semen samples were retrieved from 50 men with OAT two times: one standard 2–7 days (long ejaculation) and short duration trimming (1–2 hours later the first ejaculation). All semen parameters as well as sperm DNA integrity were compared between groups. Results showed that mean sperm concentration (10.40 vs. 8.76), total sperm count (28.53 vs. 12.24) and mean semen volume (2.69 vs. 1.40) were higher in the first ejaculation (2–7 days of abstinence), while progressive motility (20.52 vs. 13.32), non-progressive motility (53.46 vs. 48.86), morphology (2.46 vs. 1.46) and viability (83.90 vs. 77.96) were significantly higher in the second ejaculation (P < 0.05). The second sample also showed lower immotile (26.82 vs. 38.02) and DNA fragmentation (19.5 vs. 26.96) (P < 0.05). Taking all data into account, an additional short abstinence period (AP) may be a simple and helpful strategy to obtain better sperm quality in couples with male infertility causes, especially in OAT patients. The recommended current guidelines regarding the AP may need to be revisited in severe male factors.
Novel use of trametinib for treatment of atrial arrhythmia in absence of cardiomyopathy in a patient with Costello syndrome
Authors: Kato Andrew S. , Shwaish Natalie S. , Hwang Eugene Y. , Mandapati Ravi , Lee Jesse W.
Published: January 2025

We describe a case of novel use of trametinib in treating arrythmia without concomitant cardiomyopathy. Our patient is a two-year-old female born with Costello syndrome due to heterozygous mutations in the HRAS gene c34 G > T p (G12C). Shortly after birth, she was diagnosed with multifocal atrial tachyarrhythmia. Her imaging studies have shown no hypertrophy or CHD. There was poor arrhythmia control despite triple antiarrhythmic therapy. Trametinib, a MEK1 and MEK2 inhibitor, was used in treating her isolated atrial arrythmia, allowing her to wean off other antiarrhythmics. Other case reports have shown trametinib to benefit certain RASopathy patients with lymphatic abnormalities, hypertrophic cardiomyopathy, and concurrent arrhythmias. This case demonstrates effective treatment of isolated arrhythmia without cardiomyopathy, broadening the potential indications for use of trametinib in certain RASopathy patients.
Immigration is difficult?! Informing voters about immigration policy fosters pro-immigration views
Authors: Kustov Alexander , Landgrave Michelangelo
Published: January 2025

The US public is mostly ignorant about basic immigration knowledge. While various attempts to correct misperceptions have generally failed to change people’s minds about the issue, it is possible that this failure has been the result of not providing relevant information. We argue that informing the public about the difficulty of the legal immigration admission process is an effective, perspective-changing way to raise support for more open immigration policies. We test and confirm this hypothesis using a nationally representative US survey experiment (N = 1000) that informs respondents about US immigration’s administrative burdens and restrictions through short verifiable narratives. We also provide the first evidence of the widespread ignorance about the immigration process across diverse political and demographic groups. Our results suggest that providing a better understanding of the immigration process’ difficulty has more promise to change public policy preferences than challenging skeptics’ crystallized beliefs about immigration’s effects or numbers.
Expert consensus on pulpotomy in the management of mature permanent teeth with pulpitis
Authors: Zhang Lu , Lin Chen , Chen Zhuo , Yue Lin , Yu Qing , Hou Benxiang , Ling Junqi , Liang Jingping , Wei Xi , Chen Wenxia , Qiu Lihong , Li Jiyao , Niu Yumei , Lin Zhengmei , Cheng Lei , He Wenxi , Wang Xiaoyan , Huang Dingming , Huang Zhengwei , Niu Weidong , Zhang Qi , Zhang Chen , Yang Deqin , Yu Jinhua , Zhao Jin , Pan Yihuai , Ma Jingzhi , Deng Shuli , Xie Xiaoli , Meng Xiuping , Yang Jian , Zhou Xuedong , Chen Zhi
Published: January 2025

Pulpotomy, which belongs to vital pulp therapy, has become a strategy for managing pulpitis in recent decades. This minimally invasive treatment reflects the recognition of preserving healthy dental pulp and optimizing long-term patient-centered outcomes. Pulpotomy is categorized into partial pulpotomy (PP), the removal of a partial segment of the coronal pulp tissue, and full pulpotomy (FP), the removal of whole coronal pulp, which is followed by applying the biomaterials onto the remaining pulp tissue and ultimately restoring the tooth. Procedural decisions for the amount of pulp tissue removal or retention depend on the diagnostic of pulp vitality, the overall treatment plan, the patient’s general health status, and pulp inflammation reassessment during operation. This statement represents the consensus of an expert committee convened by the Society of Cariology and Endodontics, Chinese Stomatological Association. It addresses the current evidence to support the application of pulpotomy as a potential alternative to root canal treatment (RCT) on mature permanent teeth with pulpitis from a biological basis, the development of capping biomaterial, and the diagnostic considerations to evidence-based medicine. This expert statement intends to provide a clinical protocol of pulpotomy, which facilitates practitioners in choosing the optimal procedure and increasing their confidence in this rapidly evolving field.
Emerging regulatory mechanisms and functions of biomolecular condensates: implications for therapeutic targets
Authors: Jeon Soyoung , Jeon Yeram , Lim Ji-Youn , Kim Yujeong , Cha Boksik , Kim Wantae
Published: January 2025

Cells orchestrate their processes through complex interactions, precisely organizing biomolecules in space and time. Recent discoveries have highlighted the crucial role of biomolecular condensates—membrane-less assemblies formed through the condensation of proteins, nucleic acids, and other molecules—in driving efficient and dynamic cellular processes. These condensates are integral to various physiological functions, such as gene expression and intracellular signal transduction, enabling rapid and finely tuned cellular responses. Their ability to regulate cellular signaling pathways is particularly significant, as it requires a careful balance between flexibility and precision. Disruption of this balance can lead to pathological conditions, including neurodegenerative diseases, cancer, and viral infections. Consequently, biomolecular condensates have emerged as promising therapeutic targets, with the potential to offer novel approaches to disease treatment. In this review, we present the recent insights into the regulatory mechanisms by which biomolecular condensates influence intracellular signaling pathways, their roles in health and disease, and potential strategies for modulating condensate dynamics as a therapeutic approach. Understanding these emerging principles may provide valuable directions for developing effective treatments targeting the aberrant behavior of biomolecular condensates in various diseases.
Combined nerve and tendon transfer strategy for the restoration of grasp in tetraplegia; a case report
Authors: Bunketorp Käll Lina , Wangdell Johanna , Reinholdt Carina , Fridén Jan
Published: January 2025

Introduction

By combining nerve and tendon transfer procedures, a more versatile hand function can be expected. Here we report the long-term outcomes of novel, individualized reconstruction strategies using combined nerve and tendon transfer procedures (CNaTT) to restore prehension and grasp in two patients with tetraplegia.

Case presentation

Two women, 45 years of age, underwent bilateral nerve transfer according to the Bertelli S-PIN (supinator to posterior interosseous nerve transfer) procedure. The grip reconstruction included tendon transfers using brachioradialis to flexor pollicis longus and extensor carpi radialis longus to flexor digitorum profundus, as well as balancing tenodesis, arthrodesis procedures and intrinsic reconstruction. At 6 months, the patients’ pinch and grasp strength ranged between 1.0–2.0 and 2.2–5.0 kg, respectively, concomitant with improvements in activity and occupational performance. At 4–7 years after the grip reconstruction, both patients had full metacarpophalangeal (MCP) extension scoring M5 and M4, as well as full thumb extension scoring M5 and M4 on the right side. On the left side, MCP extension was weaker for both patients (M1/M2), whereas the thumb could extend against gravity (M3/M4). The maximal 1st webspace opening measured between 5 and 11 cm. Pinch strength measured between 1.25 and 2.6 kg, and whole hand grip strength between 3.9 and 7.8 kg. The patients’ grasps could fit around 80 and 50 mm wide cylinders using a normal right-handed grasp.

Discussion

The CNaTT procedure successfully restored useful grasp and release function with long-lasting effects. A large-scale controlled study is needed to confirm these findings.
Clinical validity of fluorescence-based devices versus visual-tactile method in detection of secondary caries around resin composite restorations: diagnostic accuracy study
Authors: Adly Aya Mohamed , Ibrahim Shereen Hafez , El-Zoghbi Amira Farid
Published: January 2025

Objectives

To assess the validity of light-induced and laser-induced fluorescence devices compared to the visual-tactile method for detecting secondary caries around resin composite restorations.

Materials and Methods

The study included 20 participants with 30 resin-composite restored teeth. Restorations’ margins were examined using three diagnostic methods: the visual-tactile method (FDI criteria), the light-induced fluorescence camera (VistaCam iX), and the laser-induced fluorescence device (DIAGNOdent pen), and the reference was visual inspection after removal of defective restorations. The validity of each method was evaluated. Inter-examiner reliability was calculated using Cohen’s kappa statistics. The level of significance was set at P = 0.05.

Results

DIAGNOdent pen showed the highest sensitivity (100%) followed by VistaCam (98.82%) and the visual-tactile method (98.82%) at the enamel threshold. DIAGNOdent pen and VistaCam had lower specificity values than the visual-tactile method (81.69%, 76.06%, and 88.73% respectively). At the dentin threshold, DIAGNOdent pen yielded the highest sensitivity (89.36%), whereas VistaCam had the lowest (8.51%). The sensitivity of the visual-tactile method was low (57.45%) whereas all diagnostic methods had high specificity. There was perfect agreement in inter-examiner reliability for all assessment methods (Kappa 0.858–0.992).

Conclusions

Both fluorescence-based devices and the visual-tactile method are reliable for detecting secondary caries around resin composite restorations. DIAGNOdent pen is accurate in enamel and dentin, while VistaCam and the visual-tactile method can detect secondary caries in enamel only.

Clinical Relevance

Fluorescence-based devices could be used as a valuable aid to supplement or as a second opinion after the visual-tactile method.

Trial registration

The study was listed on www.clinicaltrials.gov with registration number (NCT04426604) on 11/06/2020.
Alternative splicing in the DBD linker region of p63 modulates binding to DNA and iASPP in vitro
Authors: Lotz Rebecca , Osterburg Christian , Chaikuad Apirat , Weber Sabrina , Akutsu Masato , Machel Anne Christin , Beyer Ulrike , Gebel Jakob , Löhr Frank , Knapp Stefan , Dobbelstein Matthias , Lu Xin , Dötsch Volker
Published: January 2025

The transcription factor p63 is expressed in many different isoforms as a result of differential promoter use and splicing. Some of these isoforms have very specific physiological functions in the development and maintenance of epithelial tissues and surveillance of genetic integrity in oocytes. The ASPP family of proteins is involved in modulating the transcriptional activity of the p53 protein family members, including p63. In particular, iASPP plays an important role in the development and differentiation of epithelial tissues. Here we characterize the interaction of iASPP with p63 and show that it binds to the linker region between the DNA binding domain and the oligomerization domain. We further demonstrate that this binding site is removed in a splice variant of p63 where a stretch of five amino acids is replaced with a single alanine residue. This stretch contains a degenerate class II SH3 domain binding motif that is responsible for interaction with iASPP, as well as two positively charged amino acids. Moreover, the concomitant loss of the charged amino acids in the alternatively spliced version decreases the affinity of p63 to its cognate DNA element two- to threefold. mRNAs encoding full-length p63, as well as its alternatively spliced version, are present in all tissues that we investigated, albeit in differing ratios. We speculate that, through the formation of hetero-complexes of both isoforms, the affinity to DNA, as well as the interaction with iASPP, can be fine-tuned in a tissue-specific manner.
Collective dynamical regimes predict invasion success and impacts in microbial communities
Authors: Hu Jiliang , Barbier Matthieu , Bunin Guy , Gore Jeff
Published: January 2025

The outcomes of ecological invasions may depend on either characteristics of the invading species or attributes of the resident community. Here we use a combination of experiments and theory to show that the interplay between dynamics, interaction strength and diversity determine the invasion outcome in microbial communities. We find that the communities with fluctuating species abundances are more invasible and diverse than stable communities, leading to a positive diversity–invasibility relationship among communities assembled in the same environment. As predicted by theory, increasing interspecies interaction strength and species pool size leads to a decrease of invasion probability in our experiment. Our results show a positive correspondence between invasibility and survival fraction of resident species across all conditions. Communities composed of strongly interacting species can exhibit an emergent priority effect in which invader species are less likely to colonize than species in the original pool. However, if an invasion is successful, its ecological effects on the resident community are greater when interspecies interactions are strong. Our findings provide a unified perspective on the diversity–invasibility debate by showing that invasibility and invasion effect are emergent properties of interacting species, which can be predicted by simple community-level features.
Mycosynthesis of chitosan-selenium nanocomposite and its activity as an insecticide against the cotton leafworm Spodoptera littoralis
Authors: Ibrahiem Sohila A. , Reda Fifi M. , Abd-ElAzeem Eman M. , Hashem Mostafa S. , Ammar Hala A.
Published: January 2025

The cotton leafworm, Spodoptra littoralis, causes great damage to cotton crops. A new, safer method than insecticide is necessary for its control. Selenium nanoparticles (SeNPs) are metalloid nanomaterial, with extensive biological activities. They have low toxicity and can be used safely in plant disease management. In this study, we successfully bio-fabricated selenium nanoparticles and chitosan-selenium nanocomposite (Ch-SeNPs) using a fungal cell-free filtrate of Penicillium griseofulvum. The biosynthesized nanomaterials were initially detected optically by the formation of a red color in the solution mixture and the appearance of a strong plasmon resonance peak at 240–300 nm. The biosynthesized nanomaterials were fully characterized by UV–visible spectroscopy, transmission electron microscopy, dynamic light scattering, energy dispersive X-ray, inductively coupled plasma spectroscopy, and Fourier transform infrared. We tested the anti-insect activities of SeNPs, and Ch-SeNPs against larvae of S. littoralis compared to spore suspensions of P. griseofulvum. The results indicated that Ch-SeNPs followed by SeNPs gave a significantly higher mortality percentage than the spore suspension of the tested fungus. The highest production of all biosynthesized nanomaterials was detected after 7 days at 40 °C under alkaline conditions (pH 9). The average size diameter of SeNPs and Ch-SeNPs were 91.25 and 67.41 nm with zeta potential − 8.05 and + 41 mV, respectively. Both Ch-SeNPs and SeNPs gave high mortality rates and low values of LC50 and LC90 for both larvae and pupae. Ch-SeNPs showed stronger activity against S. littoralis than SeNPs and spore suspension at all experimental conditions. Cytotoxicity experiments indicated their safety against honeybee populations. The current study reveals the significant ultrastructure impact of SeNPs on larvae. These findings suggest that selenium nanoparticles and nanocomposite can be fabricated with a costless easy route using fungal filtrate, and they can be used safely in pest control systems that are safe for honeybee populations. It is the first report about the application of Ch-SeNPs as an anti-insect agent.
Spatial transcriptomics unveils estrogen-modulated immune responses and structural alterations in the ectocervical mucosa of depot medroxyprogesterone acetate users
Authors: Kaldhusdal Vilde , Boger Mathias Franzen , Tjernlund Annelie , Burgener Adam D. , Bradley Frideborg , Lajoie Julie , Omollo Kenneth , Kimani Joshua , Fowke Keith , Czarnewski Paulo , Broliden Kristina
Published: January 2025

The injectable contraceptive, depot medroxyprogesterone acetate (DMPA), is associated with compromised cervical mucosal barriers. High-resolution spatial transcriptomics is applied here to reveal the spatial localization of these altered molecular markers. Ectocervical tissue samples from Kenyan sex workers using DMPA, or non-hormonal contraceptives, underwent spatial transcriptomics and gene set enrichment analyses. Integrated systemic estradiol levels and bulk tissue gene expression data from a larger cohort enhanced the study’s scope. Unsupervised clustering unveiled four epithelial and seven submucosal layers, showcasing spatially restricted and diverse functional epithelial responses, and a less structured submucosal spatial ordering. DMPA associated with mucosal-wide immunoglobulin gene upregulation, verified by CD20+ B-cell immunostaining, and upregulated immune markers adjacent to the basal membrane. Downregulated genes represented spatially restricted disrupted epithelial barrier integrity and submucosal extracellular matrix dysfunction. The transcriptional profile was associated with markers of estrogen regulation. Collectively, our findings reveal estrogen-modulated distinct ectocervical transcriptional profiles associated with DMPA usage. While upregulation of immunoglobulin genes occurs throughout the mucosa, activation of innate immune responses and dysregulation of barrier integrity markers are spatially restricted. These results extend previous analyses using bulk transcriptomics and provide insights into the molecular landscape influenced by DMPA, shedding light on contraceptive effects and health implications.
Characterisation of precursory seismic activity towards early warning of landslides via semi-supervised learning
Authors: Murray David , Stankovic Lina , Stankovic Vladimir , Pytharouli Stella , White Adrian , Dashwood Ben , Chambers Jonathan
Published: January 2025

This study demonstrates that machine learning from seismograms, obtained from commonly deployed seismometers, can identify the early stages of slope failure in the field. Landslide hazards negatively impact the economy and public through disruption, damage of infrastructure and even loss of life. Triggering factors leading to landslides are broadly understood, typically associated with rainfall, geological conditions and steep topography. However, early warning at slope scale of an imminent landslide is more challenging. Through semi-supervised learning for seismic event detection from continuous seismic recordings over a period of about 10 years, we demonstrate that timely landslide induced displacement prediction is possible, providing the basis for landslide early warning systems. Our proposed methodology detects and characterises seismic precursors to landslide events making use of seismic recordings near an active slow moving earth slide-flow using a semi-supervised Siamese network. This data driven methodology identifies increase in microseismicity, and the change in the frequency spectrum of that microseismicity which identify key stages prior to a failure: ‘rest’, ‘precursor’ and ‘active’. Due to the semi-supervised nature of Siamese networks, the methodology is adaptable to discovering new types of distinct events, making it an ideal solution for precursor detection at new sites.
Research on design and control method of active vibration isolation system based on piezoelectric Stewart platform
Authors: Fang Zhiyi , Yu Zhiliang , Huang Qingping , Wang Yanfen , Gu Xingsheng
Published: January 2025

Space payloads in orbit are vulnerable to small vibrations from satellite platforms, which can degrade their performance. Traditional methods typically involve installing a passive vibration isolation system between the platform and the payload. However, such systems are usually effective only for high-frequency, large-amplitude vibrations and perform poorly in isolating low-frequency vibrations and resonances below 10 Hz. To address this limitation, this paper proposes an active vibration isolation system using a 6-degrees-of-freedom Stewart platform driven by piezoelectric actuators. First, the characteristics of the Stewart platform are analyzed and modeled, with the deformation displacement of each leg calculated through decoupling, allowing for high-precision servo control. Next, given the inherent hysteretic nonlinearity of piezoelectric ceramics, which significantly affects positioning accuracy, the hysteresis mechanism of the actuators is analyzed, and a phenomenological mathematical model based on Bouc–Wen operators is established. A Modified particle swarm optimization (MPSO) method is proposed for identifying the model’s nonlinear parameters, significantly enhancing the optimization efficiency. Finally, feedforward inverse compensation and feedback linearization methods are introduced. Experimental results verify that the designed active–passive vibration isolation system greatly improves both the positioning accuracy of the piezoelectric actuators and the active vibration isolation performance of the platform.
A computational and structural approach to identify malignant non-synonymous FOXM1 single nucleotide polymorphisms in triple-negative breast cancer
Authors: Chatterjee Prarthana , Banerjee Satarupa
Published: January 2025

The proliferation-specific oncogenic transcription factor, FOXM1 is overexpressed in primary and recurrent breast tumors across all breast cancer (BC) subtypes. Intriguingly, FOXM1 overexpression was found to be highest in Triple-negative breast cancer (TNBC), the most aggressive BC with the worst prognosis. However, FOXM1-mediated TNBC pathogenesis is not completely elucidated. Single nucleotide polymorphisms (SNPs) are the most common genetic variations causing functional and structural aberrations in proteins enhancing cancer susceptibility. This computational investigation attempted to identify the malignant FOXM1 non-synonymous SNPs (nsSNPs) and evaluate their role in affecting the conformational and functional stability, evolutionary conservation, post-translational modifications, and malignant susceptibility of the protein. Out of a huge data pool of 8826 FOXM1 SNPs using several in-silico sequence-based tools and structural approaches, four SNPs viz. E235Q, R256C, G429E and S756P were identified as pathogenic nsSNPs and among the shortlisted variants molecular dynamics simulations identified E235Q as the most damaging malignant SNP, followed by S756P. Additionally, the defective drug and DNA binding motif of E235Q and S756P were also determined in our study. Thus, although further in-vitro validations are awaited the findings of this in-silico work can be used as a blueprint for malignant nsSNP identification of FOXM1 aiding in clinical TNBC therapeutics.
An intelligent incentive-based demand response program for exhaustive environment constrained techno-economic analysis of microgrid system
Authors: Dey Bishwajit , Sharma Gulshan , Bokoro Pitshou N. , Dutta Soham
Published: January 2025

The cost-effective scheduling of distributed energy resources through sophisticated optimization algorithms is the main focus of recent work on microgrid energy management. In order to improve load factor and efficiency, load-shifting techniques are frequently used in conjunction with additional complex constraints such as PHEV scheduling and battery life assessment. Pollutant reduction, however, is rarely highlighted as a primary goal. An incentive-based demand response (IBDR) is introduced in the proposed work to close this gap and promote load curtailment during peak hours. IBDR policy rewards participant customers with incentives for load curtailment which in turn lowers emissions and generation costs. Furthermore, a trade-off approach ensures both environmental and economic sustainability by striking a balance between cost reduction and emission reduction. Considering the fact in view that the 30–40% of the microgrid customers are willing to participate in the IBDR program, six different scenarios that have been analysed, each of which involves various levels of grid participation and different approaches to pricing in the electricity market. These scenarios also include the implementation of demand response programmes. Differential evolution algorithm was used as the optimization tool for the study. The results achieved for all the scenarios demonstrate the suitability and effectiveness of implementing the suggested IBDR strategy in terms of cost savings. According to numerical results reported, the generating cost decreased by 10–13% with the inclusion of IBDR. Additionally, a 6–8% reduction in peak and 4–5% improvement in load factor was also realised as a positive impact of the IBDR policy. The weighted economic emission dispatch algorithm offered a balanced solution that considered both the minimum generation cost and emissions for various load models in the microgrid system.
Dinitramide salts based on nitropyrazole-diaminotriazole hybrid: novel ionic energetic materials with high-energy and low-sensitivity
Authors: Cai Jinxiong , Xia Yingqi , Zhang Hui , Su Dongshuai , Lai Qi , Yin Ping , Pang Siping
Published: January 2025

A pair of nitrogen-rich heterocyclic cation and oxygen-rich anion were assembled together to generate two novel dinitramide energetic salts, both of which are promising candidates for advanced secondary explosives.
Inclusion of gold ions in tiara-like nickel hexanuclear nanoclusters
Authors: Takemae Kana , Tomihari Shiho , Naito Takumi , Takagi Makito , Shimazaki Tomomi , Kawawaki Tokuhisa , Tachikawa Masanori , Negishi Yuichi
Published: January 2025

The inclusion properties of various metal ions in Ni6(PET)12 were investigated and it was found that it selectively includes gold ions.
An eco-friendly and cost-effective approach for the synthesis of a novel GA@CuO–ZnO nanocomposite: characterization, antimicrobial and anticancer activities
Authors: El-Sayyad Gharieb S. , El-Sayed El-Sayed R. , Rizk Samar H. , Abdel-Maksoud Mostafa A. , Zakri Adel M. , Malik Abdul , Malash Mohamed N. , Hashem Amr H.
Published: January 2025

In this study, a nanocomposite based on copper oxide–zinc oxide nanoparticles and Gum Arabic (GA@CuO–ZnO nanocomposite) was successfully synthesized using green method for increasing antimicrobial and anticancer activities.
Solvometallurgical recovery of antimony from waste polyvinyl chloride plastic and co-extraction of organic additives
Authors: Spooren Jeroen
Published: January 2025

A solvometallurgical process was developed to recover antimony and extract organic additives to clean PVC waste for further recycling.
Influence of aerogel mechanical properties on collagen micromorphology and its architecture
Authors: Rodriguez Sala Martina , Skalli Omar , Chandrasekaran Swetha , Worsley Marcus , Leventis Nicholas , Sabri Firouzeh
Published: January 2025

Collagen micromorphology is organized into fibers or films based on collagen concentration and aerogel surface topography.
Defect-induced new persistent cyan-emitting rare-earth-free phosphors for dynamic anti-counterfeiting and plant-growth LED applications
Authors: K. K. Thejas , Lal Sariga C. , Parayil Reshmi Thekke , Gupta Santosh K. , Das Subrata
Published: January 2025

The mixture of persistent blue and deep red-emitting systems is suitable for currency and QR code anti-counterfeiting due to the persistent blue emission and as plant growth lighting due to their emission overlapping with plant pigments’ absorption.
Robust Cartesian space tracking control of robot manipulators driven by BLDC motors: An observer based partial state feedback approach
Authors: Unver Sukru , Saka Irem , Selim Erman , Tatlicioglu Enver , Zergeroglu Erkan , Alci Musa
Published: January 2025

This study addresses the end‐effector position tracking control of robot manipulators actuated by brushless direct current (BLDC) motors under the constraint that the entire electromechanical system (i.e. kinematic, dynamic, and electrical) contains uncertain parameters, and both joint velocity and Cartesian space velocity measurements are unavailable. Specifically, a partial state feedback controller (requiring phase current measurements of BLDC motors) is presented in conjunction with a novel robust velocity observer formulation that achieves semi‐global uniform ultimate boundedness of the Cartesian space position tracking error. The stability of the closed‐loop system is ensured via Lyapunov‐type arguments. To demonstrate the efficacy of the proposed design, an experimental study is conducted on an in‐house developed, two degree of freedom planar robot manipulator driven by BLDC motors.
Parametric LCA model for power electronic ecodesign process: Addressing MOSFET‐Si and HEMT‐GaN technological issues
Authors: Fang Li , Rosset Yannis , Sarrazin Benoît , Lefranc Pierre , Rio Maud
Published: January 2025

Traditional efforts of the last decades to optimize energy efficiency during the use phase of power electronic (PE) appear insufficient for achieving environmental sustainability. These single‐criterion optimization approaches often lead to unintended negative environmental impacts, such as air, water, and soil pollutions, or additional raw material flow extraction to develop new technologies. Design options easing repair, reuse, and recycling of PE products are usually reduced with higher power density technology choices. Life cycle assessment (LCA) offers a framework for evaluating these impacts, but the conventional LCA is primarily for post‐design evaluation, and is resource‐ and time‐intensive. To make LCA a proactive design method that allows teams to monitor environmental consequences from the beginning of design planning, this study developed a parametric life cycle assessment (PLCA) meta‐model specifically for PE, integrated into an innovative ecodesign process. The PLCA meta‐model identifies key parameters influencing environmental impacts across the product life cycle and establishes mathematical relationships between these control parameters and environmental impact indicators. The case study results shows that the integration of this new PLCA model in the beginning of the design process has supported PE designers to develop, evaluate, and optimize ecodesign PE product circular life cycle scenarios.
Percutaneous Interventions and Necrosectomy in the Management of Peripancreatic Collections
Authors: Mirza-Aghazadeh-Attari Mohammad , Zakavi Seyed Sina , Ghabili Kamyar , Harfouche Melike N. , Jha Reena , Camacho Juan C. , Shaikh Jamil , Radkani Pejman , Chalhoub Walid M. , Ozen Merve , Habibollahi Peiman , Smirniotopoulos John B. , Nezami Nariman
Published: January 2025

Acute pancreatitis (AP) is a severe inflammatory condition of the pancreas with significant morbidity and mortality, particularly in its necrotizing form. This review explores the management of peripancreatic collections and in particular necrotizing pancreatitis, focusing on the evolution from traditional open surgical methods to contemporary minimally invasive image-guided techniques. AP can lead to various local complications, including pancreatic pseudocysts, acute necrotic collections, and walled-off necrosis. Imaging plays a crucial role in diagnosing complications of AP, while treatment approaches have shifted toward a step-up strategy involving percutaneous, endoscopic, and minimally invasive methods. Percutaneous necrosectomy, combining mechanical and chemical debridement, has shown promising results. Mechanical necrosectomy uses devices like baskets and retrieval nets, while chemical necrosectomy adds agents like hydrogen peroxide and streptokinase. Current evidence suggests that the step-up approach, starting with percutaneous drainage or necrosectomy and escalating to endoscopic or surgical interventions, if necessary, improves patient outcomes. The review underscores the need for a multidisciplinary approach in managing complicated AP and highlights ongoing advancements in minimally invasive techniques.
Relaxational satellites of resonance absorption of a microwave field in CuCI2·2H2O in a tilted magnetic field
Authors: Oleĭnik A. V. , Polyakov P. I. , Popov V. A.
Published: January 2025

Two types of relaxational satellites of resonance isochrones in a constant magnetic field tilted with respect to the easy axis were studied experimentally and theoretically. It was established that the “whiskers” at higher resonance field at frequencies of 3.34, 2.99, 2.64, 2.48, 2.45, and 2.42 GHz and temperatures T = 1.5 − 1.7 K are linked with multiparticle absorption of the microwave field under conditions of strong suppression of the usual antiferromagnetic resonance as a result of dephasing of the microwave field and forced oscillations of the magnetic moments. The high sensitivity of such polarization satellites to the orientation of the magnetic field relative to the easy axis makes it possible to achieve highly accurate (to within 20”) mutual orientation of the crystal and the external magnetic field. The absorption “tails,” appearing on the isochrones in the region ψ > ψs after antiferromagnetic resonance (AFMR) is cut off, are associated with relaxation processes responsible for the broadening of the usual AFMR lines, and are manifested in the region of convexity of the resonance isogonic lines. A theoretical interpretation of the nature of the “whiskers” and absorption “tails” is given, and the reason for the vanishing of AFMR in the region of the spin-flop phase transition as ψ ⟶ 0 is explained.
Observation of a quantum size effect in bismuth whiskers from the electron and hole parts of the Fermi surface
Authors: Brandt N. B. , Gitsu D. V. , Dolma V. A. , Ponomarev Ya. G.
Published: January 2025

Two groups of quantum size oscillations (QSO) of the magnetoresistance, which have different periods and exist in different ranges of magnetic field, have been determined to occur in bismuth whiskers with d ≤ 1 μ m at 4.2° K in a longitudinal magnetic field. The first group comprises QSO which are observed in fields 0<H≲Hcoe (Hcoe is the electron cutoff field) and whose periods with respect to the magnetic flux ΔΦ = 1/4ΔHΠd2 lie in the range (1−4.2)Φ0 (Φ0 is the flux quantum in the normal metal). This group of magnetoresistance QSO can be classified as Dingle oscillations due to electrons. The second group comprises high-frequency QSO, which have been observed for the first time in the range 0<H≲Hcoh (Hcoh is the hole cutoff field). The QSO in this group have dominant periods ΔΦ ∼(0.3−0.9) Φ0 with respect to flux, which are associated with Dingle oscillations of the magnetoresistance from the hole part of the bismuth Fermi surface.
Relation between the non-Josephson generation in superconducting films and the spatial structure of phase-slip centers
Authors: Churilov G. E. , Svetlov V. N. , Dmitriev V. M.
Published: January 2025

It has been established experimentally that non-Josephson generation, determined by the current density at the boundaries of a region with radius ∼ [ξ (t)l(t)] 1/2, confined within the superconducting margins, is observed in short samples whose length is less than the diffusion depth of quasiparticles. It is suggested that this phenomenon is linked with the structure of the resistive current-carrying state and with the characteristics of current transport by quasiparticles, accompanied by liberation of energy in the form of electromagnetic oscillations.
Critical fields and defect structure of vanadium deformed at 4.2 K
Authors: Aksenov V. K. , Gindin I. A. , Sokolenko V. I. , Starodubov Ya. D.
Published: January 2025

The variation of the second critical field Hc2 in coarse-grain vanadium due to torsional strain at 4.2 K is studied. In the region of elastic deformation, a slight increase in the value of Hc2 is observed. Beyond the yield point, the strain in a vanadium sample is nonuniform. In the regions of localized plastic flow (twin boundaries or large dislocation pile-ups), Hc2 and Tc increase due to an increase in the electron–phonon interaction constant.
Peculiarities of resistive transitions in metal—semiconductor granular systems
Authors: Glazman L. I. , Glukhov A. M. , Dmitrenko I. M. , Tovazhnyanskii V. L. , Fogel’ I. Ya.
Published: January 2025

Superconducting transitions are studied in granular Sn–Ge films that can be regarded as an island of tin condensate enclosed in an amorphous germanium matrix. The shape of the R vs. T transition curves is analyzed for a series of samples whose resistance Rn at 4.2 K ranges between 500 and 18,000 Ω. It is shown that the superconducting transition curves can be correctly interpreted with the help of the percolation model. The effect of the transport current I on resistive transitions is studied both theoretically and experimentally. According to the percolation model, the correction ΔR to the resistance R(T) is proportional to I and T−1. The results of experiments confirm these conclusions.
Galvanomagnetic properties of the vacancy system of RNiSn (R=Ti, Zr, Hf)
Authors: Aliev F. G. , Brandt N. B. , Kozyr’kov V. V. , Moshchalkov V. V. , Skolozdra R. V. , Stadnik Yu. V.
Published: January 2025

The first results of a study of the galvanomagnetic properties of a new interesting object —”vacancy lattice”—intermetallic compounds RNiSn (R = Ti, Zr, Hf) in which the Ni vacancies, unlike the structure of the compounds RNi2Sm, form a regular lattice, are reported. The measurements were performed in a wide temperature range (0.1 < T < 250 K) in magnetic fields up to 40 kOe. It was found that the compounds RNiSn are characterized by a low conductivity σ, close to the minimum metallic conductivity σ ∼ σmin∼100 (Ω·cm)−1. The temperature dependences of the resistivity ρ(T) of the compounds RNiSm have an unusual form for normal nonmagnetic intermetallides: in some compounds, as the temperature is lowered below room temperature, ρ(T) increases severalfold without any visible saturation at ultralow temperatures. The possible reasons for the low-temperature anomalies of the galvanomagnetic properties of the system RNiSn are analyzed.
Damping of flexural oscillations of domain walls in antiferromagnets
Authors: Ivanov B. A. , Lapchenko V. F. , Sukstanskiĭ A. L.
Published: January 2025

The rate of energy relaxation of domain-wall flexural oscillations is calculated within the framework of the microscopic treatment. The damping decrement of the flexural waves is found as a function of the temperature and the wave vector. It is shown that even in the long-wave limit the temperature dependence of the decrement differs from that in the case of progressive motion of domain walls, while the dependence of the decrement on the wave vector differs from that found using the phenomenological treatment.
Possibility of forced motion of domain walls in collinear antiferromagnets
Authors: Bar’yakhtar V. G. , Ivanov B. A. , Lapchenko V. F. , L’vov V. A.
Published: January 2025

It is shown that the presence of an alternating or nonuniform magnetic field in an antiferromagnet leads to the existence of a force which displaces the domain walls. The possibility of observing experimentally the forced motion of domain walls in collinear antiferromagnets is discussed.
Electron–electron interaction and nonequilibrium phenomena in tunnel junctions of superconductors
Authors: Ivlev V. I. , Larkin I. A.
Published: January 2025

It is shown that under the conditions of tunneling of electrons through a semiconductor junction the electron–electron interaction modifies the nonequilibrium state of the electronic system, and gives rise to a break in the current–voltage characteristic for a certain value of the voltage.
Structure and physical properties of superconducting compounds Y(La)–Ba(Sr)–Cu–O
Authors: Verkin B. I. , Banduryan B. B. , Barylnik A. S. , Batrak A. G. , Bobrov N. L. , Braude I. S. , Gal’chinetskaya Yu. L. , Gaiduk A. L. , Gurevich A. M. , Demirskii V. V. , Dotsenko V. I. , Eropkin V. I. , Zherlitsyn S. V. , Isakina A. P. , Kislyak I. F. , Konovodchenko V. A. , Lavrent’ev F. F. , Litinskaya L. S. , Mikheev V. A. , Momot V. I. , Natsik V. D. , Nechiporenko I. N. , Panfilov A. S. , Pokhil Yu. A. , Prokhvatilov A. I. , Rudavskii É. Ya. , Rybal’chenko L. F. , Svechkarev I. V. , Stepanenko A. M. , Strzhemechnyi M. A. , Fedorchenko L. I. , Fil’ V. D. , Fisun V. V. , Khomenko V. G. , Chagovets V. K. , Sheshin G. A. , Yanson I. K. , Sergienko V. V.
Published: January 2025

The structure and physical properties of superconducting compounds Y(La)–Ba(Sr)–Cu–O are studied, the compounds being prepared by the method of cryogenic dispersion of a charge consisting of premix oxides and carbonates. Electrical conductivity and critical current density of the superconductors are measured over a wide temperature range of 10 mK to 300 K. Degradation of the superconductor critical parameters in time and structural characteristics, magnetic susceptibility, heat capacity and acoustic properties are studied, and current–voltage characteristics are determined.