bluuebunny/crossref_metadata_2025 huggingface dataset:
FORENSIC-ECONOMIC EXPERTISE IN PROVING CIRCUMSTANCES THAT ARE SUBJECT TO COMPULSORY PROOF IN THE INVESTIGATION OF CRIMES IN THE FIELD OF FINANCING SOCIAL TARGETED PROGRAMS
Authors: Viter D.
Published: April 2020

Traces of criminal activities in the field of financing social targeted programs are often reflected in a number of documents that this activity is issued and accompanied. In this regard, one of the leading places in the investigation of criminal proceedings for such crimes are expert studies on the use of techniques and methods for diagnosing the financial and economic situation of the enterprise. The purpose of the article is to outline the features of forensic economic expertise and to highlight their capabilities in proving circumstances that are subject to mandatory proving when investigating crimes in the field of financing social targeted programs. The article emphasizes that the results of economic research in the form of a conclusion of a forensic expert is one of the sources of evidence in criminal proceedings, which is objective and reflects the correlation relations in the criminal process regarding the establishment of objective truth in a particular criminal proceeding and its solution. essentially.

It was noted that the practice of investigation and consideration by the courts of crimes in the field of financing social targeted programs indicates that there are not many cases in which the issues that are addressed by it go beyond the limits of expert knowledge, which indicates the problem of identifying the initiator of examination of the species and subspecies Forensic-economic expertise, the characteristics of the subject and object of this expertise and its subspecies are given. The attention is drawn to the fact that the practical activity of an expert, the limits of his competence in determining the range of issues that he can solve depends on the correct definition of the subject and the object of the examination. It is established that one of the peculiarities of committing crimes in the sphere of financing social targeted programs is that they are committed by officials using multi-combinations and related to the concealment of data in accounting documents. It is proved that all collected valid and fictitious documents, informal notes of materially responsible persons should be attached to the materials of the proceedings; interrogated all persons who can testify about the crime in the sphere of funding social targeted programs, as well as all the expert opinions, the conclusions of which can be used by an expert-economist to provide an expert’s opinion.
RESOLUTION OF ISSUES RELATED TO THE USE OF LAND PLOTS NOT FOR THE PURPOSE PURPOSE WHEN CARRYING OUT A JUDICIAL ECONOMIC EXPERTISE
Authors: Chumachenko N.
Published: April 2020

The relevance of the census is by the fact that it is the first-rate property for all significant means of justice, disputable persons, as well as perusal of civil rights, and of the rest of the country, and at the same time, at the same time, at the same time, N 963 «Techniques for rozmіru shkodi, zapodіyanono ї vnasdok samovilny zaynyattya land dіlyanok, vikoristannya land dіlyanok not for the whole ryazanennyam, knowing the ground crookedness (I’m using the same mask, I didn’t have a draw).
The Method № 963 is hidden on the assignment to the distributor, the authorities, the territorial communities, the legal entities, the legal entities, all the categories of land in the land and land areas, not the main reason, which is not the main reason.
The state monopoly (control) at the part of the land legislation, the victorious and the safeguarding of the lands of all categories and the forms of authority, is attached to the Derzhgeokadastre.
It is prescribed by the Law of Ukraine «On state control over the damage and protection of land» from 19 June 2003, p. N 963-IV of the sovereign control over the victorians and the defense of the earths can be crossed by the cross.
In response to a visit to the Roshraunker Rozmir, to be under the supervision of the Victory Day in the land of the Red Army, not in accordance with the appropriate standards, refer to the administrative provisions of the state registrars and the workers, but also to the lawyers in the field

The act of registration of the law of land legislation;
protocol on administrative law enforcement;
pripis (with the usushenya pushenenya land legislation);
act of land registration.

The procedure for the assignment to the distributor of the schoolchildren, according to the rules of the localization of the land of the girls, is not the same as the assignment of the procedure, clause 5 of Method № 963.
An overview of the data for this type of expertise є Rosrahunok rozmіru shkodi, zavdo їnask dikoristannya land dylyanki not for the purpose.
Judicial examiner — economist to carry out the completion of the correctness of the assignment to the direct ordering of the skoda, induced in the above-mentioned Rosrahunka for the complete assembly of the Inspector.
The result of the ship examiner’s examination of the economist’s case is that of the hanging of the vessel itself, at the same time as the control body of the Technique № 963.
Қар жабындысының ауыр металдармен ластануын бағалау
Authors: Мырзаханова Ә , Кожина Ж
Published: April 2020

Бұл жұмыста қар суының ауыр металдармен ластануы туралы мәлiметтеркелтiрiлген. Зерттеуге қажеттi материалдар жиналды. Су сынамаларын жинау үшiн арнайыбелгiленген аймақтарда конверт әдiсi пайдаланылды. Ерiген қар суының ластануын зерттеукезiнде ауыр металдардың бары не жоғы анықталды. Нұр-Сұлтан қаласының аумағындағықар жабындысындағы Cu, Сo, Ni, Mn, Cd, Zn, Pb концентрациясы атомды-абсорбциондыәдiстерi арқылы анықталды. Жүргiзiлген зерттеу нәтижелерi қар жабындысының қабатындаауыр металдардың бар екенiн көрсеттi. Ластаушылардың негiзгi құрамын келесi металдарқұрады: Cu, Сo, Ni, Mn, Cd, Zn, Pb және концентрациясы мг/л-мен өлшендi. Салыстырмалыталдау негiзiнде, ауыр металдардың құрамы барлық сынамалар бойынша шектi рұқсат етiлгенконцентрациядан төмен екенi белгiлi болды. Қар суындағы ауыр металдардың бар болуыатмосфералық ауаның ластануымен, әсiресе автокөлiктерден болатын техногендi ластанументүсiндiрiледi. Бұл фактiлер аймақ бойынша ауа мен қар жабындысын ауыр металдарға кезеңбойынша тексеру қажет екенiн көрсетедi.
Geographical diversity and changes in foreign trips from Poland in 2009-2018
Authors: Jan Wendt
Published: April 2020

In 2009 foreign tourist traffic from Poland amounted to around 5.5 million people, toreach the number of over 12 million Poles in 2018 who went abroad for holidays. Due to the volumeof tourist traffic, this phenomenon requires research. The purpose of the analysis, on the one hand,is to indicate the main geographical directions of tourist trips from Poland, and on the other handthe changes that have occurred in destinations chosen by tourists from Poland in the last ten years.The work also attempts to indicate the main factors affecting changes in tourist destinations.Political changes, Poland’s accession to the EU, economic changes, and the global economic crisisare obviously accompanied by changes in tourism, its size and the choice of leisure destinations forPoles. How important this problem is shown not only by the above data, but also by changes amongthe most frequently chosen geographical tourist destinations for Poles. The paper presents changesin the number of tourists in the largest tourist destinations from Poland. An attempt was alsomade to analyze changes in the volume of charter tourist traffic, which most accurately indicatesthe numerical changes and assessment of geographical changes in directions of foreign tourism fromPoland.
Формирование структуры строительных материалов из чётырех компонентов
Authors: Айбульдинов Е , Колпек А , Искакова Ж , Абдиев К
Published: April 2020

В статье разработан метод укрепления широко распространенного природногосуглинка Казахстана щелочным шлаком металлургического комбината, красным шламомобогащения боксита и отходами производства извести. Разработанные основания значительноувеличивают прочность и долговечность автодорог.
Влияние красного света на образование железоорганических комплексов в природной воде
Authors: Сергазина С , Алпысова А , Пятов Е
Published: April 2020

Экспериментальным путем установлено изменение химических свойств водыпо отношению к железу при воздействии на нее красным светом в различном временноминтервале: при воздействии на воду красным светом в течение одной минуты отмечаетсянаименьшая химическая активность воды к образованию растворимых комплексов железас органическими примесями по сравнению с другими временными экспозициями. Воснову заявляемого способа определения химической активности органических соединенийв водных растворах лежит оценка свойств индивидуальных органических соединений либонескольких соединений, присутствующих в водном растворе, по отношению к соединениямжелеза. В качестве контролируемого свойства лежит способность органических соединений ккомплексообразованию, которая оценивается по значению коэффициента активности (Ka) [6].Определение общего железа в воде проводилось до и после воздействия красным светом.Продолжительность воздействия красным светом на воду (в мин.): 0,5; 1; 5; 10; 20;30. В качестве контрольного образца применяли дистиллированную воду с металлическойпластиной, учитывая, что дистиллированная вода не содержит органические примеси.
Битумдардың микро- және наноқұрылымын зерттеу
Authors: Койшыгулова А , Тажкенова Г , Саурбаева Б
Published: April 2020

Битумның негiзгi қасиеттерiне оң әсер ету деңгейi олардың бетiндегiкөмiрсутек радикалдарының ұзындығының өсуiмен бiрдей эфирлену дәрежесiменжоғарылайтындығы анықталды. Төмен қышқылданған атактикалық полипропиленi барбитумдарға эфирленген қосымша енгiзу жұмыс қабiлеттiлiгiнiң температуралық аралығынкеңейтуге және жол битумын байланыстырғыштың адгезиялық қасиеттерiн жақсартуғамүмкiндiк беретiндiгi анықталды. Тазартылған кремнеземдi және аз тотыққан атактикалықполипропилендi битум байланыстырғышқа бiрiккенде адгезияның жоғарылауына негiзгiүлес тиесiлi екендiгi анықталды. Соңғы уақытта трафиктiң күрт артуымен қатар жолдарғаантропогендiк әсер күшейе түстi. Бұл қышқылдың жауын-шашынының, тұз бен қышқылдыңмұздану жүйелерiнiң агрессивтi әсерiнен, ластанған атмосфераның әсерiнен және т.б.нәтижесiнде болады. Климаттық және табиғи өзгерiстер байқалды. Нөлдiк градусаймағындағы температура айырмашылығы факторлардың әсерiнен жолдардың асфальтбетонжабындарының қарқынды бұзылуына әкеледi.
Аккумуляция тяжелых металлов съедобными грибами Восточного Казахстана
Authors: Сабитова А , Мусабаева Б , Баяхметова Б , Гайсина Б
Published: April 2020

Статья посвящена изучению аккумуляции тяжелых металлов органамисъедобных грибов Boletusedulis, растущих на территории г. Семей и за городом.Проанализированы полученные результаты по содержанию меди, цинка, кадмия и свинцав съедобных грибах и сделаны выводы, что грибы, растущие в городе, более загрязненытяжелыми металлами, чем за городом, т.е. грибы являются чуткими биоиндикаторамисостояния экологической среды. Тяжелые металлы накапливаются в них не только из почвы,но и из воздуха. Важнейшими источниками загрязнения окружающей среды в ВосточномКазахстане являются черная и цветная металлургия, обжиг цементного сырья, сжиганиетоплива, автомобильные выбросы.
Population-Resources Dynamics
Authors: Telles Charles
Published: April 2020

Dynamics of population and resources symmetries are investigated and a model of ecological interaction was obtained. It was observed how variables in these dynamics are in recurrence considering parameters such as time, frequency, iteration, interaction and frequency of iteration. Variables investigated are the consume, idleness and supply mechanics and time series analysis of these variables indicated a possible phase space formation of the phenomena. The main conclusion leads to a nonlinear dynamics of the  ecological interactions of the organisms and resources symmetries.
论水利工程对生态环境的影响评价
Authors: 张 晓原
Published: April 2020

水利水电工程是十分重要的民生工程,由于施工技术和施工水平有限,水利工程建设中也会对生态环境造成不同程度的影响。在工程建设中,应建立更为科学和完善的生态环境影响评价指标体系,进而明确生态环境破坏现状,采取有效的改进措施。本文就将分析水利工程对生态环境的影响评价,以供参考。
环境监测与环境影响评价关系分析
Authors: 徐 梦非 , 李 颖
Published: April 2020

环境监测在环境影响评价体系中扮演着重要的角色,而环境影响评价工作也应以准确的环境监测数据为基础,因此二者之间密不可分。本文主要分析了环境监测与环境影响评价的关系,以供参考。
城市环境保护中的污水治理问题与对策研究
Authors: 陈 蕾
Published: April 2020

随着水污染问题的日益加重,国家对污水处理的重视力度也在加强,采取合理的污水处理措施,减少水污染问题,不仅可以保障人们的日常生活安全,也可对生态环境的治理和保护起到很好的推动作用。本文就对城市环境保护中,污水治理中的问题进行分析,并提出科学有效的解决措施,以改善水环境质量。
论以现代科技文明引领城市生态环境建设
Authors: 王 倩倩
Published: April 2020

生态文明是对传统工业文明的扬弃和超越,旨在推动资源节约型、环境友好型社会发展。城市生态文明建设是一项系统工程,其涉及面广、工作量大,需以科学高效的现代技术作为技术保障。目前,现代科技在引领生态城市建设方面早已通过网络信息化、自动化等先进的技术对生态环境建设形成了有力支撑。本篇文章主要以现代科技引领城市生态文明建设作为论题的中心内容,望能够对我国现代化生态城市建设工作的开展起到一定的可参考价值。
Формування організаційно-економічного механізму управління трансформаціями системи економічної безпеки підприємства
Authors: Івченко Є.А.
Published: April 2020

В статті розглянуто теоретичні та інструментальні засади формування механізму управління трансформаціями системи економічної безпеки підприємства. За результатами дослідження визначено підходи до формування організаційно-економічного механізму трансформаціями системи економічної безпеки підприємства. Визначено процесний підхід до формування організаційно-економічного механізму трансформаціями системи економічної безпеки підприємства найбільш придатним для використання. Запропоновано формування організаційно-економічного механізму трансформаціями системи економічної безпеки підприємства на основі використання синтаксису IDEF. Формалізовано процес побудови механізму управління трансформаціями системи економічної безпеки підприємства та визначено його окремі складові.
Система управління інтелектуальним капіталом підприємства
Authors: Кушал І.М. , Харьковська Ю.О.
Published: April 2020

Статтю присвячено актуальній проблемі щодо побудови ефективної системи управління інтелектуальним капіталом на вітчизняних підприємствах. У науковій праці розглянуто сутність категорії інтелектуальний капітал та його складові, визначено форми розвитку інтелектуального капіталу та теоретико-методичні засади, пов'язані з формуванням системи управління інтелектуальним капіталом підприємства. Встановлено, що для раціонального управління інтелектуальними ресурсами необхідна дієва система. Збільшення прибутку й конкурентних переваг суб’єкта господарювання, активізація бізнес-процесів, пов’язаних з інноваціями, свідчать про ефективне формування, використання та розвиток інтелектуального капіталу. Перспективним напрямом подальших досліджень у даній проблематиці є розробка методичних підходів до управління інтелектуальним капіталом у межах підприємств різних видів діяльності.
EVALUATING SCIENTIFIC REASONING ABILITY: THE DESIGN AND VALIDATION OF AN ASSESSMENT WITH A FOCUS ON REASONING AND THE USE OF EVIDENCE
Authors: Luo Ma , Wang Zuhao , Sun Daner , Wan Zhi Hong , Zhu Liying
Published: April 2020

Scientific reasoning ability (SRA) is widely recognized as an essential goal for science education. There is much discussion on the design and development of assessment frameworks as viable tools to foster SRA. However, established assessments mostly focus on the level of students reasoning attainment. Student ability to use evidence to support reasoning is not adequately addressed and evaluated. In this study, the 6-level SRA assessment framework was conceptualized and validated iteratively via synthesizing literature and a Delphi study. Guided by the framework, an SRA assessment tool adopting and adapting PISA test items and self-created items was developed and administered to 593 secondary students (including 318 8th Graders and 275 9th Graders) in mainland China. Pearson correlation analysis of SRA assessment score and their scores in scientific reasoning provided criterion-related validation for the former (Pearson correlation = .527). Rasch analysis conducted further confirmed the validity and reliability of the SRA test and the assessment framework. Combing quantitative and qualitative methods, the study provides a valid and reliable analytical framework of SRA. It can inform the design of SRA assessments in various science education contexts for diversified audiences.
Keywords: Complexity of Scientific Reasoning, Evidence in Reasoning, Rasch Modeling, Scientific Reasoning Ability (SRA).
TINGKAT PEMAHAMAN PERATURAN PERMAINAN SEPAKBOLA (LAW OF THE GAME) WASIT C-2 DAN C-1 ASPROV PSSI BENGKULU
Authors: Yarmani Yarmani , Irwanto Dika
Published: April 2020

Penelitian ini bertujuan untuk mengetahui tingkat pemahaman wasit terhadap peraturan permainan sepakbola. Penelitian ini merupakan penelitian deskriptif kualitatif. Metode yang digunakan dalam penelitian ini adalah metode survei. Instrumen yang digunakan adalah angket. Instrumen yang telah tersusun tersebut dikonsultasikan kepada ahli (expert judgment). Populasi dalam penelitian ini adalah wasit sepakbola C-2 dan C-1 Asprov PSSI Bengkulu dengan jumlah 25 orang. Teknik analisis data yang dilakukan adalah analisis deskriptif dengan persentase. Hasil penelitian menunjukkan bahwa tingkat pemahaman peraturan permainan sepakbola (Laws Of The Game) wasit C-2 dan C-1 Asprov PSSI Bengkulu berada pada kategori sangat baik sebesar 92% (23 orang), kategori baik sebesar 8% (2 orang), kategori cukup sebesar 0%, kategori kurang 0%,dan kategori sangat kurang 0%. Dengan rincian lisensi yaitu sebanyak 6 orang lisensi C-1 dan 17 orang lisensi C-2 termasuk ke kategori sangat baik sedangkan 2 orang berlisensi C-2 termasuk ke kategori baik.
Analysis of the RSA-cryptosystem in abstract number rings
Authors: Kondratyonok Nikita V.
Published: April 2020

Quantum computers can be a real threat to some modern cryptosystems (such as the RSA-cryptosystem). The analogue of the RSA-cryptosystem in abstract number rings is not affected by this threat, as there are currently no factorization algorithms using quantum computing for ideals. In this paper considered an analogue of RSA-cryptosystem in abstract number rings. Proved the analogues of theorems related to its cryptographic strength. In particular, an analogue of Wiener’s theorem on the small secret exponent is proved. The analogue of the re-encryption method is studied. On its basis the necessary restrictions on the parameters of the cryptosystem are obtained. It is also shown that in numerical Dedekind rings the factorization problem is polynomial equivalent to factorization in integers.
On the continuity of functors of the type C(X, Y)
Authors: Kukrak Hleb O. , Timokhovich Vladimir L.
Published: April 2020

We consider the category P, the objects of which are pairs of topological spaces (X, Y). Each such pair (X, Y) is assigned the space of continuous maps Cτ(X, Y) with some topology τ. By imposing some restrictions on objects and morphisms of category P, we define a subcategory K ⊂ P, for which the above map is a functor from K to the category Top of topological spaces and continuous maps. The following question is investigated. What are the additional conditions on K, under which the above functor is continuous? Along the way the problem of finding the limit of the inverse spectrum in the category P is solved. We show, that it reduces to finding the limits of the corresponding direct spectrum and inverse spectrum in the category Top. Point convergence topology, compact-open topology and graph topology are considered as the topology τ.
Application of formal methods in the design of a collaborative virus defense system
Authors: Sharykin Raman E. , Kourbatski Alexander N.
Published: April 2020

This article proposes an approach that allows us to study a mathematical model of a virus protection system at the stage of its design using statistical analysis of an executable model specification based on the formalism of Distributed Object Based Stochastic Hybrid Systems (DOBSHS). Important aspects of the model are its distributed and probabilistic nature. These aspects make the model more difficult to carry out attacks, but at the same time significantly complicate the understanding of its properties by the developer. In this example, we show how, using the specification of the system as a DOBSHS model, coupled with its statistical analysis, we can investigate its properties at an early stage of design and how, using this approach, we can detect «defects» of the model and correct them during the process of creating the model.
Service Quality and Customer Satisfaction in the Apiculture-Based Agritourism
Authors: Gandhy Abel , Chang Michael , Rahmi Siti
Published: April 2020

Taman Wisata Lebah is tourism service based on honey bees. It is one of the pioneer of the apitourism in Indonesia. The objective of this reserach are to analyze the service quality and customer satisfaction of Taman Wisata Lebah. Research method used in this research is quantitative. Respondent in this research are 100 respondents, using purposive sampling technique. Data analysis techniques are Importance Performance Analysis (IPA) and Customer Satisfaction Index (CSI). Based on the calculation of CSI, the number is indicated that in general consumers of Taman Wisata Lebah are satisfied with the services provided. Findings. Based on the calculation of Importance Performance Analysis, there are five attributes with high importance and low performance and highly recomended to improve. The atributes consists of provide more safety equipment for customers, evaluate staff shifting schedule to ensure the existence of staff in field, improvement product knowledge for field staff, create safety box for bee colony. Overall, service quality in Taman Wisata Lebah is excellent.
“LET’S WRITE A CAPTION!”: UTILIZING INSTAGRAM TO ENHANCE ESP STUDENTS’ WRITING SKILLS
Authors: Nugroho Arif , Rahmawati Any
Published: April 2020

The integration of technology in language classroom is a prerequisite in the twenty-first century teaching. Social media as part of technology advancement has a great potential to improve students’ motivation and the efficacy of learning a language. Therefore, the present study sheds light on the effect of the use of Instagram on ESP students’ writing ability. It involved 36 Indonesian ESP students majoring in Sharia Banking of a university in Surakarta Indonesia. The pre-experimental research was conducted in eight meetings, including the writing pre-test and post-test. The students were assigned to write a descriptive essay by means of Instagram as the instructional medium. A questionnaire was also given to reveal their perceptions toward the use of Instagram to practice writing. The result of the data analysis showed that there was a significant difference on the students’ writing scores between the pre-test and the post test. The finding of this study is expected to provide significant contribution to the realm of English for specific purposes (ESP) teaching in Indonesia. Based on the findings, some insights are given for teachers and future researchers about the potential use of Instagram on the teaching of writing.
The Need for Machine-Processable Agreements in Health Data Management
Authors: Konstantinidis George , Chapman Adriane , Weal Mark J. , Alzubaidi Ahmed , Ballard Lisa M. , Lucassen Anneke M.
Published: April 2020

Data processing agreements in health data management are laid out by organisations in monolithic “Terms and Conditions” documents written in natural legal language. These top-down policies usually protect the interest of the service providers, rather than the data owners. They are coarse-grained and do not allow for more than a few opt-in or opt-out options for individuals to express their consent on personal data processing, and these options often do not transfer to software as they were intended to. In this paper, we study the problem of health data sharing and we advocate the need for individuals to describe their personal contract of data usage in a formal, machine-processable language. We develop an application for sharing patient genomic information and test results, and use interactions with patients and clinicians in order to identify the particular peculiarities a privacy/policy/consent language should offer in this complicated domain. We present how Semantic Web technologies can have a central role in this approach by providing the formal tools and features required in such a language. We present our ongoing approach to construct an ontology-based framework and a policy language that allows patients and clinicians to express fine-grained consent, preferences or suggestions on sharing medical information. Our language offers unique features such as multi-party ownership of data or data sharing dependencies. We evaluate the landscape of policy languages from different areas, and show how they are lacking major requirements needed in health data management. In addition to enabling patients, our approach helps organisations increase technological capabilities, abide by legal requirements, and save resources.
Urinalysis in Great Dane Puppies from Birth to 28 Days of Age
Authors: Melandri Monica , Veronesi Maria Cristina , Alonge Salvatore
Published: April 2020

Urinalysis, a common test in infants, could represent a suitable non-invasive clinical tool in puppies. In dog neonates, urine is easily collected by stimulating the somato-vesccal reflex. Information on urine characteristics during the neonatal period is missing. Beside instrumental laboratory analyses, the dipstick was proven useful for rapid urinalysis to evaluate specific gravity (SG), pH, leukocytes, nitrites, glucose, proteins, ketones, urobilinogen, bilirubin, and blood. The present study aimed to describe urinalysis features by the dipstick test and refractometer along the neonatal period. Urine samples (n = 624) were collected by manual stimulation from 48 healthy Great Danes, daily from birth to seven days, then twice a week until 28 days, to assess age-related changes (ANOVA, p < 0.05) and the possible effects of gender and litter (T-test, p < 0.05). The SG and pH significantly changed during the neonatal period. Other parameters did not vary significantly in relation to age. No significant differences were observed either among litters or between genders. The present study confirmed that canine kidneys are able to concentrate urine from the second week of age when the urinary SG started to be similar to adults, while pH still increased towards the typical values of adults at 28 days. Significant glucosuria and proteinuria were never detected. Dipstick urinalysis represents a useful first-line complementary tool in newborns clinical examination, providing information about systemic homeostasis.
Parasite Occurrence and Parasite Management in Swedish Horses Presenting with Gastrointestinal Disease—A Case–Control Study
Authors: Hedberg-Alm Ylva , Penell Johanna , Riihimäki Miia , Osterman-Lind Eva , Nielsen Martin K. , Tydén Eva
Published: April 2020

All grazing horses are exposed to intestinal parasites, which have the potential to cause gastrointestinal disease. In Sweden, there is a concern about an increase in parasite-related equine gastrointestinal disease, in particular Strongylus vulgaris, since the implementation of prescription-only anthelmintics approximately 10 years ago. In a prospective case–control study, parasitological status, using fecal analyses for strongyle egg counts, the presence of Anoplocephala perfoliata eggs and S. vulgaris Polymerase chain reaction (PCR) as well as serology for S. vulgaris, were compared between horses presenting with or without gastrointestinal disease at a University hospital during a one-year period. Information regarding anthelmintic routines and pasture management was gathered with an owner-filled questionnaire. Although the prevalence of S. vulgaris PCR was 5.5%, 62% of horses were positive in the enzyme-linked immunosorbent assay (ELISA) test and horses with peritonitis showed higher antibody levels for S. vulgaris, as compared to other diagnoses or controls. Overall, 36% of the horse owners used only fecal egg counts (FEC), 32% used FEC combined with specific diagnostics for S. vulgaris or A. perfoliata, and 29% dewormed routinely without prior parasite diagnostics. Effective management methods to reduce the parasitic burden on pastures were rare and considering exposure to S. vulgaris appears high; the study indicates a need for education in specific fecal diagnostics and pasture management.
Identification of Crucial Genetic Factors, Such as PPARγ, that Regulate the Pathogenesis of Fatty Liver Disease in Dairy Cows Is Imperative for the Sustainable Development of Dairy Industry
Authors: Shi Kerong , Li Ranran , Xu Zhongjin , Zhang Qin
Published: April 2020

Frequently occurring fatty liver disease in dairy cows during the perinatal period, a typical type of non-alcoholic fatty liver disease (NAFLD), results in worldwide high culling rates of dairy cows (averagely about 25%) after calving. This has been developing into a critical industrial problem throughout the world, because the metabolic disease severely affects the welfare and economic value of dairy cows. Findings about the molecular mechanisms how the fatty liver disease develops would help scientists to discover novel therapeutic targets for NAFLD. Studies have shown that PPARγ participates or regulates the fat deposition in liver by affecting the biological processes of hepatic lipid metabolism, insulin resistance, gluconeogenesis, oxidative stress, endoplasmic reticulum stress and inflammation, which all contribute to fatty liver. This review mainly focuses on crucial regulatory mechanisms of PPARγ regulating lipid deposition in the liver via direct and/or indirect pathways, suggesting that PPARγ might be a potential critical therapeutic target for fatty liver disease, however, it would be of our significant interest to reveal the pathology and pathogenesis of NAFLD by using dairy cows with fatty liver as an animal model. This review will provide a molecular mechanism basis for understanding the pathogenesis of NAFLD.
Effects of Microencapsulated Blend of Organic Acids and Essential Oils as a Feed Additive on Quality of Chicken Breast Meat
Authors: Stamilla Alessandro , Russo Nunziatina , Messina Antonino , Spadaro Carmine , Natalello Antonio , Caggia Cinzia , Randazzo Cinzia L. , Lanza Massimiliano
Published: April 2020

The present study aims to investigate the effect of dietary supplementation based on a blend of microencapsulated organic acids (sorbic and citric) and essential oils (thymol and vanillin) on chicken meat quality. A total of 420 male Ross 308 chicks were randomly assigned to two dietary treatments: the control group was fed with conventional diet (CON), while the other group received the control diet supplemented with 0.5% of a microencapsulated blend of organic acids and essential oils (AVI). In breast meat samples, intramuscular fat content and saturated/polyunsaturated fatty acids ratio were reduced by AVI supplementation (p < 0.05). Moreover, atherogenic (p < 0.01) and thrombogenic (p < 0.05) indices were lower in AVI than CON treatment. AVI raw meat showed a lower density of psychrotrophic bacteria (p < 0.05) at an initial time, and higher loads of enterococci after 4 days of refrigerated storage (p < 0.05). No contamination of Listeria spp., Campylobacter spp., and Clostridium spp. was found. TBARS values of the cooked meat were lower in the AVI treatment compared to CON (p < 0.01). Among colour parameters, a*, b* and C* values increased between 4 and 7 days of storage in AVI cooked meat (p < 0.05). Overall, organic acids and essential oils could improve the quality and shelf-life of poultry meat.
The Outdoor Field Test and Energy Yield Model of the Four-Terminal on Si Tandem PV Module
Authors: Araki Kenji , Tawa Hiroki , Saiki Hiromu , Ota Yasuyuki , Nishioka Kensuke , Yamaguchi Masafumi
Published: April 2020

The outdoor field test of the 4-terminal on Si tandem photovoltaic module (specifically, InGaP/GaAs on Si) was investigated and a performance model, considering spectrum change affected by fluctuation of atmospheric parameters, was developed and validated. The 4-terminal on Si tandem photovoltaic module had about 40% advantage in seasonal performance loss compared with standard InGaP/GaAs/InGaAs 2-terminal tandem photovoltaic module. This advantage increases (subarctic zone < temperate zone < subtropical zone). The developed and validated model used an all-climate spectrum model and considered fluctuation of atmospheric parameters. It can be applied every type of on-Si tandem solar cells.
Adhesion between Epoxy Resin-Based Fiber Post and Dental Core Resin Improved by Non-Thermal Atmospheric Pressure Plasma
Authors: Kim Hyoung-Sik , Yang Song-Yi , Choi Eun Ha , Kim Kwang-Mahn , Kwon Jae-Sung
Published: April 2020

The purpose of the study was to evaluate the adhesion between dental core resin and epoxy resin-based fiber post after treatment with non-thermal atmospheric pressure plasma (NTAPP) and compare with conventional methods of epoxy resin-based fiber post treatments. Contact angle was measured on the surface of epoxy resin before and after NTAPP treatment and X-ray photoelectron spectroscopy was used to analyze the surface chemistry. Finally, two shear bond strength tests were carried out; shear bond strength between core resin and epoxy resin for comparison between NTAPP treated and untreated sample, and push-out shear bond strength between core resin and NTAPP treated commercially available epoxy resin-based fiber post for comparison between NTAPP treated samples with conventionally treated samples. Contact angle on the surface of epoxy resin generally decreased with increasing NTAPP treatment time with presence of surface chemical changes. Also, there was significantly higher shear bond strength and push-out shear bond strength between epoxy resin and core resin for NTAPP treated epoxy resin, even to the conventionally treated epoxy resin-based fiber post with hydrofluoric acid or silane. In conclusion, new technology of NTAPP has potential for application on the epoxy resin-based fiber post to improve endodontic restoration success rate.
An Adaptive Sliding Mode Variable Admittance Control Method for Lower Limb Rehabilitation Exoskeleton Robot
Authors: Tu Yao , Zhu Aibin , Song Jiyuan , Shen Huang , Shen Zhitao , Zhang Xiaodong , Cao Guangzhong
Published: April 2020

As passive rehabilitation training with fixed trajectory ignores the active participation of patients, in order to increase the active participation of patients and improve the effect of rehabilitation training, this paper proposes an innovative adaptive sliding mode variable admittance (ASMVA) controller for the Lower Limb Rehabilitation Exoskeleton Robot. The ASMVA controller consists of an outer loop with variable admittance controller and an inner loop with an adaptive sliding mode controller. It estimates the wearer’s active muscle strength and movement intention by judging the deviation between the actual and standard interaction force of the wearer’s leg and the exoskeleton, thereby adaptively changing admittance controller parameters to alter training intensity. Three healthy volunteers engaged in further experimental studies, including trajectory tracking experiments with no admittance, fixed admittance, and variable admittance adjustment. The experimental results show that the proposed ASMVA control scheme has high control accuracy. Besides, the ASMVA can not only increase training intensity according to the active muscle strength of the patient during positive movement intention (so as to increase active participation of the patient), but also increase the amount of trajectory adjustment during negative movement intention to ensure the safety of the patient.
Research on Lane Detection Based on Global Search of Dynamic Region of Interest (DROI)
Authors: Hu Jianjun , Xiong Songsong , Sun Yuqi , Zha Junlin , Fu Chunyun
Published: April 2020

A novel lane detection approach, based on the dynamic region of interest (DROI) selection in the horizontal and vertical safety vision, is proposed to improve the accuracy of lane detection in this paper. The curvature of each point on the edge of the road and the maximum safe distance, which are solved by the lane line equation and vehicle speed data of the previous frame, are used to accurately select the DROI at the current moment. Next, the global search of DROI is applied to identify the lane line feature points. Subsequently, the discontinuous points are processed by interpolation. To fulfill fast and accurate matching of lane feature points and mathematical equations, the lane line is fitted in the polar coordinate equation. The proposed approach was verified by the Caltech database, under the premise of ensuring real-time performance. The accuracy rate was 99.21% which is superior to other mainstream methods described in the literature. Furthermore, to test the robustness of the proposed method, it was tested in 5683 frames of complicated real road pictures, and the positive detection rate was 99.07%.
Indoor Comfort and Symptomatology in Non-University Educational Buildings: Occupants’ Perception
Authors: Campano-Laborda Miguel Ángel , Domínguez-Amarillo Samuel , Fernández-Agüera Jesica , Acosta Ignacio
Published: April 2020

The indoor environment in non-university classrooms is one of the most analyzed problems in the thermal comfort and indoor air quality (IAQ) areas. Traditional schools in southern Europe are usually equipped with heating-only systems and naturally ventilated, but climate change processes are both progressively increasing average temperatures and lengthening the warm periods. In addition, air renewal is relayed in these buildings to uncontrolled infiltration and windows’ operation, but urban environmental pollution is exacerbating allergies and respiratory conditions among the youth population. In this way, this exposure has a significant effect on both the academic performance and the general health of the users. Thus, the analysis of the occupants’ noticed symptoms and their perception of the indoor environment is identified as a potential complementary tool to a more comprehensive indoor comfort assessment. The research presents an analysis based on environmental sensation votes, perception, and indoor-related symptoms described by students during lessons contrasted with physical and measured parameters and operational scenarios. This methodology is applied to 47 case studies in naturally ventilated classrooms in southern Europe. The main conclusions are related to the direct influence of windows’ operation on symptoms like tiredness, as well as the low impact of CO2 concentration variance on symptomatology because they usually exceeded recommended levels. In addition, this work found a relationship between symptoms under study with temperature values and the environmental perception votes, and the special impact of the lack of suitable ventilation and air purifier systems together with the inadequacy of current thermal systems.
Ensemble-Based Data Assimilation of Volcanic Ash Clouds from Satellite Observations: Application to the 24 December 2018 Mt. Etna Explosive Eruption
Authors: Pardini Federica , Corradini Stefano , Costa Antonio , Esposti Ongaro Tomaso , Merucci Luca , Neri Augusto , Stelitano Dario , de’ Michieli Vitturi Mattia
Published: April 2020

Accurate tracking and forecasting of ash dispersal in the atmosphere and quantification of its uncertainty are of fundamental importance for volcanic risk mitigation. Numerical models and satellite sensors offer two complementary ways to monitor ash clouds in real time, but limits and uncertainties affect both techniques. Numerical forecasts of volcanic clouds can be improved by assimilating satellite observations of atmospheric ash mass load. In this paper, we present a data assimilation procedure aimed at improving the monitoring and forecasting of volcanic ash clouds produced by explosive eruptions. In particular, we applied the Local Ensemble Transform Kalman Filter (LETKF) to the results of the Volcanic Ash Transport and Dispersion model HYSPLIT. To properly simulate the release and atmospheric transport of volcanic ash particles, HYSPLIT has been initialized with the results of the eruptive column model PLUME-MoM. The assimilation procedure has been tested against SEVIRI measurements of the volcanic cloud produced during the explosive eruption occurred at Mt. Etna on 24 December 2018. The results show how the assimilation procedure significantly improves the representation of the current ash dispersal and its forecast. In addition, the numerical tests show that the use of the sequential Ensemble Kalman Filter does not require a precise initialization of the numerical model, being able to improve the forecasts as the assimilation cycles are performed.
Bioenergetics of the Dictyostelium Kinesin-8 Motor Isoform
Authors: Koonce Michael P. , Tikhonenko Irina
Published: April 2020

The functional organization of microtubules in eukaryotic cells requires a combination of their inherent dynamic properties, interactions with motor machineries, and interactions with accessory proteins to affect growth, shrinkage, stability, and architecture. In most organisms, the Kinesin-8 family of motors play an integral role in these organizations, well known for their mitotic activities in microtubule (MT) length control and kinetochore interactions. In Dictyostelium discoideum, the function of Kinesin-8 remains elusive. We present here some biochemical properties and localization data that indicate that this motor (DdKif10) shares some motility properties with other Kinesin-8s but also illustrates differences in microtubule localization and depolymerase action that highlight functional diversity.
Effect of Olfactory and Gustatory Dysfunction and Motor Symptoms on Body Weight in Patients with Parkinson’s Disease
Authors: Masala Carla , Loy Francesco , Piras Raffaella , Liscia Anna , Fadda Laura , Moat Alan , Solla Paolo , Defazio Giovanni
Published: April 2020

Background: Non-motor symptoms in Parkinson’s disease (PD) are often associated with a negative impact on the patients’ quality of life and on their weight regulation. The aim of this study was to assess the effect of olfactory and gustatory dysfunction, apathy, fatigue, depression, and motor symptoms on weight regulation in PD patients. Methods: We analyzed 112 participants, 63 PD patients (mean age ± SD: 69.2 ± 10.1), and 49 controls (mean age ± SD: 68 ± 9.6). For each participant we collected age, weight, height, BMI, olfactory and gustatory function, cognitive performance, apathy and fatigue. Results: Our data showed that 61.9% (n = 39) of PD patients had hyposmia, while 38.1% (n = 24) had anosmia. In PD patients, we observed a significant effect of Unified Parkinson’s Disease Rating Scale (UPDRS), apathy, odor threshold, sweet perception and fatigue on weight regulation. Instead, there was no significant effect for depression and levodopa equivalent daily dosage (LEDD). Conclusion: Our results suggest that PD non-motor symptoms such as olfactory/gustatory deficits and mood disorders may influence body weight.
An Updated Perspective on Current Prognostic and Predictive Biomarkers in Chronic Lymphocytic Leukemia in the Context of Chemoimmunotherapy and Novel Targeted Therapy
Authors: Cohen Jared A. , Bomben Riccardo , Pozzo Federico , Tissino Erika , Härzschel Andrea , Hartmann Tanja Nicole , Zucchetto Antonella , Gattei Valter
Published: April 2020

Chronic lymphocytic leukemia (CLL) is a heterogeneous disease with a variable clinical course. Novel biomarkers discovered over the past 20 years have revolutionized the way clinicians approach prognostication and treatment especially in the chemotherapy-free era. Herein, we review the best established prognostic and predictive biomarkers in the setting of chemoimmunotherapy (CIT) and novel targeted therapy. We propose that TP53 disruption (defined as either TP53 mutation or chromosome 17p deletion), unmutated immunoglobulin heavy chain variable region gene status (UM IGHV), NOTCH1 mutation, and CD49d expression are the strongest prognosticators of disease progression and overall survival in the field of novel biomarkers including recurrent gene mutations. We also highlight the predictive role of TP53 disruption, UM IGHV, and NOTCH1 mutation in the setting of CIT and TP53 disruption and CD49d expression in the setting of novel targeted therapy employing B-cell receptor (BCR) and B-cell lymphoma-2 (BCL2) inhibition. Finally, we discuss future directions in the field of biomarker development to identify those with relapsed/refractory disease at risk for progression despite treatment with novel therapies.
Development of a Model for Chemical Screening Based on Collateral Sensitivity to Target BTK C481S Mutant
Authors: Libre Camille , Moro-Sibilot Ludovic , Giraud Stéphane , Martin Laetitia , Verhoeyen Els , Costa Caroline , Chebel Amel , Bissay Nathalie , Salles Gilles , Genestier Laurent , Sujobert Pierre
Published: April 2020

Targeted therapies have improved the outcome of cancer, but their efficacy is intrinsically limited by the emergence of subclones with a mutation in the gene encoding the target protein. A few examples of collateral sensitivity have demonstrated that the conformational changes induced by these mutations can create unexpected sensitivity to other kinase inhibitors, but whether this concept can be generalized is unknown. Here is described the development of a model to screen a library of kinase inhibitors for collateral sensitivity drugs active on the Bruton Tyrosine Kinase (BTK) protein with the ibrutinib resistance mutation C481S. First, we demonstrate that overexpression of the constitutively active mutant of BTK harboring the E41K mutation in Ba/F3 cells creates an oncogenic addiction to BTK. Then, we have exploited this phenotype to perform a screen of a kinase inhibitor library on cells with or without the ibrutinib resistance mutation. The BTK inhibitors showed the expected sensitivity profile, but none of the drugs tested had a specific activity against the C481S mutant of BTK, suggesting that extending the collateral sensitivity paradigm to all kinases targeted by cancer therapy might not be trivial.
The Effect of AgInS2, SnS, CuS2, Bi2S3 Quantum Dots on the Surface Properties and Photocatalytic Activity of QDs-Sensitized TiO2 Composite
Authors: Malankowska Anna , Kulesza Daria , Sowik Jakub , Cavdar Onur , Klimczuk Tomasz , Trykowski Grzegorz , Zaleska-Medynska Adriana
Published: April 2020

The effect of type (AgInS2, SnS, CuS2, Bi2S3) and amount (5, 10, 15 wt%) of quantum dots (QDs) on the surface properties and photocatalytic activity of QDs-sensitized TiO2 composite, was investigated. AgInS2, SnS, CuS2, Bi2S3 QDs were obtained by hot-injection, sonochemical, microwave, and hot-injection method, respectively. To characterize of as-prepared samples high-resolution transmission electron microscopy (HRTEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), UV-Vis spectroscopy and photoluminescence (PL) emission spectroscopy were applied. The size of AgInS2, SnS, CuS2, Bi2S3 QDs were 12; 2–6; 2–3, and 1–2 nm, respectively. The QDs and QDs-sensitized TiO2 composites obtained have been tested in toluene degradation under LEDs light irradiation (λmax = 415 nm and λmax = 375 nm). For pristine QDs the efficiency of toluene degradation increased in the order of AgInS2 < Bi2S3 < CuS < SnS under 375 nm and AgInS2 < CuS < Bi2S3 < SnS under 415 nm. In the presence of TiO2/SnS QDs_15% composite, 91% of toluene was degraded after 1 h of irradiation, and this efficiency was about 12 higher than that for pristine QDs under 375 nm. Generally, building the TiO2/AgInS2 and TiO2/SnS exhibited higher photoactivity under 375 nm than the pristine TiO2 and QDs which suggests a synergistic effect between QDs and TiO2 matrix.