bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship between Neutrophil Gelatinase‐Associated Lipocalin, Eosinophil Cationic Protein, Cytokines, and Atopic Sensitization in Patients with Allergic Diseases
Authors: Choi Jong Weon , Lee Moon Hee , Fujii Tatsuyoshi
Published: June 2022

The effect of neutrophil gelatinase‐associated lipocalin (NGAL) on eosinophil activation, atopic sensitization, and systemic inflammation in allergic diseases has rarely been investigated. This study aimed to investigate the relationship between NGAL, eosinophil cationic protein (ECP), cytokines, and allergen‐specific immunoglobulin E (sIgE) in allergic diseases. A total of 136 patients with allergies and 58 healthy individuals were evaluated. The concentrations of NGAL, ECP, tumor necrosis factor‐α (TNF‐α), interleukin‐5 (IL‐5), sIgE, total IgE (tIgE), and high‐sensitivity C‐reactive protein (hsCRP) were measured. The transforming growth factor‐β1 (TGF‐β1) level was measured as a profibrotic marker of bronchial asthma. Allergic patients had significantly higher NGAL, ECP, and hsCRP levels than healthy individuals. However, there was no significant difference in NGAL levels between patients with positive and negative ECP tests and those with high and low sIgE scores. Asthmatic patients with elevated NGAL exhibited a significantly higher TGF‐β1 level than those without elevated NGAL. However, no significant difference was observed in the ECP, IL‐5, and sIgE levels between the two groups. Among the patients with a positive ECP test, subjects with elevated hsCRP had two times higher NGAL levels than those without elevated hsCRP. NGAL was positively correlated with TNF‐α, TGF‐β1, and hsCRP, but not with ECP, IL‐5, tIgE, and sIgE. An elevated NGAL level led to a 1.3‐fold increase in the prevalence of high TGF‐β1 (odds ratio: 1.31; 95% CI: 1.04–2.58; P < 0.001). In conclusion, NGAL elevation may be more closely linked to allergic inflammation and a possible fibrotic change in the airways than to the severity of eosinophil activation and atopic sensitization.
Two Complex Graph Operations and their Exact Formulations on Topological Properties
Authors: Hameed Shehla , Jamil Muhammad Kamran , Waheed Muhammad , Azeem Muhammad , Swaray Senesie
Published: June 2022

Graph operations are utilized for developing complicated graph structures from basic graphs, and these basic graphs can help to understand the properties of complex networks. While on the other side, the topological descriptor is known as a numeric value that is associated with the graph of a network. It has enormous practical applications in chemistry and other fields of science. This particular work in this draft is the extended work and investigated the first, second, first multiplicative, first reformulated Zagreb indices, and the forgotten index of subdivision double corona and subdivision double neighborhood corona products.
Relationship of Blood Group with Level of Cooperation of Pediatric Dental Patients
Authors: Heidari Alireza , Salehi Shahrabi Marzieh , Askari Anaraki Elnaz
Published: June 2022

Acquaintance with the behavior of children in dental office setting is highly important in treatment success. People with different blood groups often have different behaviors. Thus, the blood group may aid in prediction of behavior of pediatric dental patients. This study is aimed at assessing the relationship of the blood group with level of cooperation of pediatric dental patients. This cross‐sectional study was conducted on 130 children between 4 and 6 years of age. The blood group of children was recorded according to their identification card or by collecting an intraoral blood sample during pulpotomy and using the respective kit. To assess the level of cooperation of children, their behavior was videotaped during the procedure, and the videos were assessed by two pedodontists. The behavior of children was scored according to the Venham scale. Data were analyzed by SPSS 26 and Chi‐square, Fisher’s exact test, and Mann–Whitney U test. The blood group was A in 35.7%, B in 5.8%, AB in 3.2%, and O in 53.5%. Children with blood group O had maximum cooperation (52.6) while those with blood group B had minimum cooperation. Pairwise comparisons of the groups regarding the Venham scale revealed significant differences between blood groups A and B (P = 0.0001) and also B and O (P = 0.005). Pairwise comparisons of the groups regarding the level of cooperation also revealed significant differences between blood groups A and B (P = 0.0001) and B and O (P = 0.019). Blood group B may be correlated with certain behavioral traits such as dental fear and anxiety and the resultant poor cooperation.
Evaluation of the Thermophysical, Sensory, and Microstructural Properties of Colombian Coastal Carimañola Obtained by Atmospheric and Vacuum Frying
Authors: Acevedo C. Diofanor , Montero Piedad M. , Meza Jhon Rodriguez , Sandrith Sampayo R. , Martelo Raul Jose
Published: June 2022

The quality of fried products affects consumer purchase decisions, and frying is an important stage in the production process. The objective of this research was to evaluate the thermophysical properties, the sensory quality, and microstructure of Colombian coastal Carimañola traditionally manufactured, in atmospheric frying and vacuum frying conditions. Lower moisture and fat content were reported in samples fried under vacuum compared to samples fried under atmospheric conditions, which is associated with the vacuum pressure during the process. Thermophysical properties, related to heat transfer in the samples, showed a correlation between thermal conductivity and moisture content. The micrographs visualized the changes in the porous structure of the coastal Carimañola. A greater effect was evidenced in the samples obtained by atmospheric frying because higher temperatures were used. The sensory evaluation reflected a preference for Carimañolas made with conventional frying. This research provides a basis for consumer purchases of traditionally fried products made with vacuum frying.
Prevalence of Helminthic Infections in the Gastrointestinal Tract of Cattle in Mazandaran Province (Northern Iran)
Authors: Nouri Nasrollah Vahedi , Rahmatian Reza , Salehi Alireza
Published: June 2022

Ruminant parasites are found in all parts of the world, including the tropical and subtropical regions. Mazandaran province (northern Iran) is one of the areas prone to the activity of gastrointestinal parasites in ruminants. This study was performed in 2020, in order to identify common parasites of cattle gastrointestinal tract, the percentage of the infection, the effect of seasons, and livestock on the amount of infection and determine the severity of infection. In this study, seven genera of gastrointestinal parasites including Strongyloides, Haemonchus, Ostertagia, Cooperia, Trichostrongylus, Oesophagostomum, and Chabertia were identified among 240 cattle. Overall, 34.58% of cows were infected with different kinds of parasites. Based on the average percentage of livestock infected with gastrointestinal parasites across different seasons, winter had the lowest percentage (18.33%) compared to other seasons, which has a statistically significant difference (

P
<
0.05

). Also, we observe that the female cattle’s infection rate, in comparison with males, had no significant difference (

P
<
0.05

). Moreover, 67.17% of the cattle had a moderate level of infection. Despite the fact that farmers use antiparasitic drugs, helminthic infections in cattle are still high. In conclusion, the lack of proper implementation of helminthic infection control programs as well as antiparasitic drug resistance in this area can be a key element for the high prevalence of livestock helminthic infection in these areas.
University Education Management Model Based on Artificial Intelligence Programming and Analysis Technology Foundation for Building Models and Applications
Authors: Huang Ming
Published: June 2022

The reform and development of university education management are operating according to their own laws with the changes of the internal environment of education and the social external environment such as politics, economy, science and technology, and culture. As a branch of the mechanism of university education management, the operation mechanism of university education management supports the reform and development of university education management. This article studies the construction of a university education management model based on an intelligent programming analysis method. The research shows that the average score of the control class before the experiment is 63.7748 and the average score of the experimental class is 63.8954. It can be seen that the average score difference between the two classes is only 0.1206. Understand the performance changes of various dynamic forces by gradually contacting complex structures. Through building + intelligent programming, we can preliminarily understand programming and increase children’s interest in programming; strengthen programming ability; learn various complex structures; and lay a good foundation for later intelligent programming. This article studies the intelligent programming education of university education management and solves the problems existing in University Programming Education by formulating relevant policies, changing teaching methods and using after-school time, so as to optimize the teaching effect.
Machine Learning-Enabled Development of Model for Japanese Film Industry
Authors: Xiao-ling Wang , Zhi-long Liu , Madina Zamira
Published: June 2022

Not only are numerous components absorbed and modified in terms of movie subjects, but also various art forms like painting and music are researched and examined in the production of Japanese cinema, resulting in the development of film styles with national characteristics. The fundamental role of film industrialization is to increase production efficiency, reduce industry risks, create job opportunities, and provide related technologies and services for professional creative people, so that the creativity crystallization of all industry insiders can become an invisible creative power and tangible economic values in the economy and can circulate continuously within the overall film industry structure. On the basis of summering and analyzing of previous research works, this article expounded the research status and significance of Japanese film industry, elaborated the development background, current status, and future challenges of film industry model, introduced the creation and production of genre films in Japanese film industry, established the relationship between personalized creation and market trend of Japanese films, proposed the competition and cooperation model for the distribution of local and imported films, analyzed the market share of sequel and anime films in Japanese film industry, conducted the analysis of terminal construction changes and localized cinema lines operation, and discussed the exploration and management model of film screening bodies. The research results of this article provide a reference for further researches on the development model of Japanese film industry.
Synthesis and Characterization of Activated Carbon from Agrowastes for the Removal of Acetic Acid from an Aqueous Solution
Authors: Njewa Joel Brian , Biswick Timothy Tiwonge , Vunain Ephraim , Lagat Cheruiyot Silas , Lugasi Solomon Omwoma
Published: June 2022

In this study, activated carbons prepared from agrowastes by chemical activation were used to remove acetic acid from an aqueous solution through a batch process. The prepared adsorbents were characterized by SEM, XRD, FT-IR, and point of zero charge (pHpzc). The effects of adsorbent dosage, initial concentration, and contact time were considered. Equilibrium data was tested using Langmuir, Freundlich, Temkin, and Frenkel–Halsey–Hill models. The degree of adsorption of acetic acid increased for both adsorbents as contact time, and adsorbent dosage and initial concentration were increased. The adsorption data were described well by the (Freundlich=Frenkel–Halsey–Hill) models with the highest regression coefficient of [Formula: see text] and [Formula: see text] for Rice Husk Activated Carbon (RH-AC) and Potato Peels Activated Carbon (PP-AC), respectively. This suggests a multilayer through the existence of a heterogeneous pore distribution in the adsorbent surface. Kinetic data agreed well with pseudosecond-order ([Formula: see text] and [Formula: see text]) RH-AC and PP-AC, correspondingly. This indicates that the adsorption process was chemisorption in nature. The regeneration studies showed that the adsorbents prepared could be renewed and reused before losing their adsorbing affinity for acetic acid.
[Retracted] The Effect of Calisthenics on Hypoglycemic of Diabetic Patients
Authors: Wu Gang , Qu Haili
Published: June 2022

Objective. To analyze the effect of calisthenics on hypoglycemic in diabetic patients. Method. From September 2019 to May 2020, 210 patients with type 2 diabetes who were newly diagnosed in our hospital were chosen. They were split into two groups: observation (n = 105) and control (n = 105). Only drug therapy and diet management were given to the control group, whereas the observation group was given calisthenics treatment in addition to regular diet control and medicine. The outcomes of the two groups of patient’s blood glucose levels, BMI, quality of life, and blood lipid index were compared in this study. Results. Before treatment, there was no significant difference in FPG, 2hPG, and HbA1c levels between the two groups (P > 0.05). Compared with before treatment, FPG, 2hPG, and HbA1c were significantly reduced in both groups (P < 0.05). In addition, FPG, 2hPG, and HbA1c in the observation group were significantly lower than those in the control group (P < 0.05). There was no significant difference in BMI between the two groups before treatment (P > 0.05). After treatment, the BMI of the two groups was significantly reduced (P < 0.05), and the BMI of the observation group was significantly lower than that of the control group (P < 0.05). A comparison of the two groups’ SF‐36 scale scores before intervention revealed no statistically significant difference (P > 0.05). The observation group’s SF‐36 scores were substantially higher than the control group’s after intervention (P < 0.05). After treatment, the TC and HDL‐c levels in the observation group were not significantly different from those in the control group (P > 0.05). Compared with the control group, TG and LDL‐C levels were significantly decreased, with statistically significant differences (P < 0.05). Conclusion. Based on routine nursing intervention, using calisthenics to treat blood sugar has a significant effect, it not only made the patient’s self‐care ability significantly improved, which was worthy of active promotion in clinical practice.
Adsorption of Polyphenols from Almond Blanching Water by Macroporous Resin
Authors: Tabib Malak , Ginies Christian , Rakotomanomana Njara , Remmal Adnane
Published: June 2022

The almond processing industry generates large volumes of effluent after the blanching process. Blanching water is one of the main by-products with a potential source of polyphenols. However, before being used or discharged, this by-product requires pretreatment. This work was aimed at paving the way toward using adsorption on XAD-7 HP macroporous resin for wastewater treatment. This promising technique could be easily scaled up and integrated into existing production lines. Adsorption was carried out with a fixed bed in counterflow, while desorption was performed by acetone in downflow. With this approach, it was possible to concentrate up to five times the phenolic content of the initial blanching water. The resulting extract was analyzed by ultraperformance liquid chromatography-mass spectrometry (UPLC-MS), identifying more than 89% procyanidins, in addition to catechin, epicatechin, and isorhamnetin-3-O-rutinoside. Applications such as spray-drying and prilling techniques were suggested to improve the efficiency of polyphenols by preserving their stability, bioactivity, and bioavailability.
Comprehensive Analysis Identifies PI3K/Akt Pathway Alternations as an Immune-Related Prognostic Biomarker in Colon Adenocarcinoma Patients Receiving Immune Checkpoint Inhibitor Treatment
Authors: Lin Anqi , Gu Tianqi , Hu Xigang , Zhang Jian , Luo Peng
Published: June 2022

Introduction. In recent years, immune checkpoint inhibitors (ICIs) have attracted widespread attention and made breakthroughs in progress towards the treatment of various cancers. However, ICI therapy is selective, and its effects on many patients are not ideal. It is therefore critical to identify prognostic biomarkers of response to ICI therapy. The PI3K/Akt pathway plays important roles in tumor formation and metastasis. However, there are no published reports clarifying the relationship between PI3K/Akt pathway mutations and prognosis for colon adenocarcinoma (COAD) patients receiving immunotherapy. Methods. We collected data from a COAD cohort from The Cancer Genome Atlas (TCGA) database, including whole-exome sequencing (WES) data, RNA-seq data, and clinical data. We also collected data, including clinical prognosis and targeted sequencing data, from a cohort of COAD patients receiving immunotherapy. We collected 50 COAD patients (Local-COAD) from the Zhujiang Hospital of Southern Medical University and performed targeted sequencing. We analyzed the effects of PI3K/Akt pathway mutations on the patients’ clinical prognosis, immunogenicity, and immune microenvironments. Gene set enrichment analysis (GSEA) was used to analyze the significantly upregulated and downregulated signaling pathways. We used these results to hypothesize potential mechanisms by which PI3K/Akt mutations could affect the prognosis of COAD patients. Results. Univariate and multivariate Cox analyses and Kaplan-Meier (KM) survival curves showed that patients with PI3K-Akt mutations had better overall survival (OS) than those without PI3K-Akt mutations. Genes with significant mutation rates in the two cohorts were screened by panoramic view. CIBERSORT was used to analyze changes in 22 types of immune cells to identify immune activated cells. Similarly, patients in the PI3K/Akt-mutated type (PI3K/Akt-MT) group had significantly increased immunogenicity, including increases in tumor mutation burden (TMB), neoantigen load (NAL), and MANTIS score. Using GSEA, we identified upregulated pathways related to immune response. Conclusion. PI3K/Akt pathway mutation status can be used as an independent predictor of response to ICI treatment in COAD patients. PI3K/Akt mutations are correlated with improved OS, higher immunogenicity, greater immune response scores, and increases in activated immune cells.
Transient Complete Recovery of Chronic Refractory Idiopathic Thrombocytopenic Purpura after Treatment with Monoclonal Antibody Targeting SARS-CoV-2 Spike Protein
Authors: Gogia Pooja , Xu Yiqing
Published: June 2022

Idiopathic thrombocytopenic purpura (ITP), also known as immune thrombocytopenic purpura, is an immune-mediated acquired disease characterized by transient or persistent decrease of the platelet count due to autoimmune-related destruction of platelets. Therapy for ITP relies on competing and inhibiting the autoantibody binding and destruction (intravenous immunoglobulin and anti-D immunoglobulin and spleen tyrosine kinase (Syk) inhibitor fostamatinib), augmenting platelet production (thrombopoietin receptor agonists), immunosuppression to reduce the autoantibody production, as well as splenectomy. Studies on autoantigens on the platelets suggested epitopes to be located predominantly on the GP IIb/IIIa receptor or integrin αIIbβ3, though the trigger for the development of ITP is unclear. We report a case here of a 37-year-old gentleman who has chronic ITP managed on eltrombopag, who after receiving monoclonal antibody against SARS-CoV-2 (mAb) i.e. casirivimab and imdevimab for his COVID-19 infection, demonstrated complete recovery of his platelet count for a short period of time. We discuss a few potential mechanisms of action and propose further studies to elucidate the therapeutic effect of COVID-19 mAb in ITP.
Logistics Optimization Strategy Based on Deep Neural Framework
Authors: Liu Guangqian , Zhu Yiming
Published: June 2022

We propose a logistics optimization method based on improved graph convolutional networks to address the current problem of low product delivery rate and untimely product delivery during the peak period of e-commerce activities. Our method can learn excellent planning strategies from previous data and can give the best logistics strategy in time during the peak logistics period, which improves the product delivery rate and delivery time of logistics and greatly enhances the return on investment. First, we add a tensor rotation module to the graph convolution layer to better capture the global features of logistics nodes. Then we add inception structures in the temporal convolution layer to build multiscale temporal convolution filters to obtain temporal information of logistics nodes in different time-aware domains and reduce arithmetic power. Finally, we cooperate with e-commerce platforms to adopt logistics data as the experimental database. The experimental results show that our method greatly accelerates the logistics planning speed, improves the product delivery rate, ensures the timely delivery of products, and increases the return on investment.
Construction and Validation of a UPR‐Associated Gene Prognostic Model for Head and Neck Squamous Cell Carcinoma
Authors: Wang Tao , Chen Lingling , Xie Fuping , Lin Shiqi , Lin Yuhan , Chen Jiamin , Liu Huanhuan , Wu Ye
Published: June 2022

Our study is aimed at constructing and validating a UPR‐associated gene signature to predict HNSCC prognosis. We obtained 544 samples of RNA sequencing data and clinical characteristics from TCGA database and randomly grouped the samples into training and testing cohorts (1 : 1 ratio). After identifying 14 UPR‐associated genes with LASSO and univariate Cox regression analysis, HNSCC samples were categorized into low‐risk (LR) and high‐risk (HR) subgroups depending on the risk score. Our analyses indicated that low‐risk patients had a much better prognosis in the training and testing cohorts. To predict the HNSCC prognosis with the 14 UPR‐associated gene signatures, we incorporated the UPR gene risk score, N stage, M stage, and age into a nomogram model. We further explored the sensitivity to anticancer drugs by using the IC50 analysis in two subgroups from the Cancer Genome Project database. The outcomes showed that the AKT inhibitor III and sorafenib were sensitive anticancer drugs in HR and LR patients, respectively. The immune cell infiltration analysis and GSEA provided strong evidence for elucidating the molecular mechanisms of UPR‐associated genes affecting HNSCC. In conclusion, the UPR‐associated gene risk score, N stage, M stage, and age can serve as a robust model for predicting prognosis and can improve decision‐making at the individual patient level.
Incidence of Early and Late-Onset Clostridioides difficile Infection following Appendectomy Compared to Other Common Abdominal Surgical Procedures
Authors: Sadik K.W. , Hranjec T. , Bonatti H. J. R. , Sawyer R.G.
Published: June 2022

Introduction. Clostridioides difficile associated diarrhea (CDAD) is a major public health issue. The appendix may function as a reservoir for the intestinal microbiome, which may repopulate the intestine following enteric infections including CDAD. Patients/Methods. This retrospective cohort study includes a total of 12,039 patients undergoing appendectomy, hemicolectomy, and cholecystectomy at a single center between 1992 and 2011 who were diagnosed with early and late-onset CDAD and were followed for a minimum of two years. Results. Cumulative CDAD rates were 2.3% after appendectomy, 6.4% after left and 6.8% after right hemicolectomy, and 4% after cholecystectomy with a median onset of 76 (range 1–6011) days after the procedure. Median time to CDAD onset was 76 days after appendectomy, 23 days after left, 54 days after right hemicolectomy, and 122 days after cholecystectomy (

p
<
0.05

). Late-onset CDAD (>1 year) was significantly more common following appendectomy (37%) and cholecystectomy (39%) than after left (17%) and right (21%) hemicolectomy. Significant differences in age, gender, complication rate, and length of hospitalization between the four groups need to be considered when interpreting the results. Conclusion. The incidence of CDAD after various abdominal surgeries ranged between 2% and 7% in this study. Whereas, hemicolectomy patients had predominantly early onset CDAD, and appendectomy and cholecystectomy may increase the risk for late-onset CDAD. Appendectomy per se does not seem to increase the risk for late-onset CDAD.
Phase Prediction Study of High-Entropy Energy Alloy Generation Based on Machine Learning
Authors: He Zhongping , Zhang Huan
Published: June 2022

Traditional energy sources such as fossil fuels can cause environmental pollution on the one hand, and on the other hand, there will be a shortage of diminishing stocks. Recently, a variety of new energy sources have been proposed by scientists, such as nuclear energy, hydrogen energy, wind energy, water energy, and solar energy. There are already many technologies for converting and storing energy generated from new energy systems, such as various storage batteries. One of the keys to the commercialization of these new energy sources is to explore new materials. Researchers have performed a lot of research on new energy material preparation, mechanical properties, radiation resistance, energy storage, etc. However, new energy metal materials are still unable to combine radiation resistance, good mechanical properties, excellent energy storage, and other characteristics. There is still a lack of breakthrough materials with better performance or more stable structure. Recently, researchers have discovered that high-entropy alloys have become one of the most promising new energy metal materials. Because it not only has high energy storage and high strength, but also has high stability and high radiation resistance, and is easy to form a simple phase, the prediction of phases in high-entropy energy alloys is very critical, and the generation of designed phases in high-entropy energy alloys is a very important step. In this study, three machine learning algorithms were used to predict the generated phase classification in high-entropy alloys, namely, support-vector machine (SVM) model, decision tree (DT) model, and random forest (RF) model. The models are optimized by grid search methods and cross-validated, and performance was evaluated with the aim of significantly improving the accuracy of generative phase prediction, and the results show that the random forest algorithm has the best prediction ability, reaching 0.93 prediction accuracy. The ROC (receiver operating characteristic) curve of the model shows that the random forest algorithm has the best classification of solid-solution (SS) phases, where the classification probabilities AUC (area under the curve) area for amorphous phase (AM), intermetallic phase (IM), and solid-solution phase (SS), respectively, are 0.95, 0.96, and 1, respectively, , which can predict the generated phases of high-entropy energy alloys well.
Increase in Suspended Sediment Contents by a Storm Surge in Southern Bohai Sea, China
Authors: Zhang Yongqiang , Sun Yongfu , Hu Zejian , Bian Shuhua , Xiong Congbo , Liu Jianqiang , Chi Wanqing , Zhang Wanjun
Published: June 2022

Most of the existing results were related to the impact of land storms on sediment, and few explained the impact of storms on sediment movement and its formation law from the mechanism. At present, the research on the impact of storm on sediment suspension on the North Bank of Longkou City in the south of Bohai Sea was not clear. Therefore, this study aimed to explore the formation and mechanism of storm on suspended sediment from the perspective of hydrodynamic characteristics and sediment distribution by monitoring the impact of storm on sediment suspension in the south of Bohai Sea. A storm with wind speeds of 4.5–13.5 m/s occurred in the coastal area of the north side of Longkou City located in Southern Bohai Sea in April, 2015. Suspended sediment samples were obtained using automatic samplers, and the results showed that the suspended sediment content was 7.8 mg/L under normal weather conditions, which reached 121.2 mg/L at the highest during the storm event. Waves and tides were synchronously observed by acoustic Doppler current meter. Wave height was more closely correlated with wind speed when the wind veered to north, and the maximum wave height was 243 cm. The reciprocating motion of the current at the sampling site was strong, with the maximum current speed of 43.8 cm/s and a water depth of 10 m. The results of laser analysis showed that the bottom sediments were composed of 92% sand and 8% silt, with a medium diameter of 0.102 mm. From the experimental observation and result analysis, it was known that the strong dynamic process during storm surge led to the movement of sediment surface and the resuspension of sediment.
Systematic Review on Multilevel Analysis of Radiation Effects on Bone Microarchitecture
Authors: Bakar Ayuni Amalina Abu , Mohamad Noor Shafini , Mahmud Mohd Hafizi , Razak Hairil Rashmizal Abdul , Sudin Ann Erynna Lema Thomas , Shuib Solehuddin
Published: June 2022

Introduction. Modern radiation therapy has become an effective method to treat and monitor tumour growth in cancer patients. It has proved to be a successful way to minimise mortality rates. However, the adverse effects of radiation have been historical evidence in the clinical environment involving diminishing the quality and density of bone and causing fragility fracture to the bone in the long run. This systematic review was aimed at identifying and evaluating the effects of irradiation on morphology and mechanical properties of murine model bone in previous publications. Methods. A systematic literature review was undertaken following the Preferred Reporting Items for Systemic Reviews and Meta‐analysis (PRISMA) guidelines. A comprehensive literature search was performed using Scopus, Web of Science, and Science Direct databases (English only studies published between 2015 and 2020). The selected studies were evaluated according to three criteria: (1) criteria for study sample selection; (2) criteria for methodological procedures; and (3) criteria for detection and evaluation. Results. The initial search strategy identified 1408 related studies, 8 of were included based on inclusion and exclusion criteria. This review revealed an association between bone destruction and the magnitude of time and dose postirradiation. We agreed that the effect of radiation on bone morphology and strength primarily is a later stage event but noticeable in both low (1 Gy) and high dose (30 Gy) radiation. Trabecular and cortical bone microstructures were significantly altered at irradiation and contralateral sites. Besides, the mechanical strength was significantly impacted in both shorter and longer periods. Conclusion. Overall, the radiotherapy altered bone microstructures and substantially decreases bone mechanical properties. The alteration was related to quantity and the activity of the osteoblast and osteoclast. Early detection of those most at risk for radiation‐induced bone alterations could lead to better prophylactic intervention decisions.
Immunoglobulin G4-Related Disease Presenting as Temporal Bone Lesion with Facial Nerve Palsy
Authors: Polianskis Marius , Ivaška Justinas , Dadonienė Jolanta , Lengvenis Givi , Besusparis Justinas , Rauba Darius , Morozas Arnoldas , Ivaškienė Tatjana , Lesinskas Eugenijus
Published: June 2022

Immunoglobulin G4-related disease (IgG4-RD) is a systemic condition which could present as local infiltration of skull base structures. We report a case of IgG4-RD with infiltration of the temporal bone and surrounding structures in a patient with systemic vasculitis on systemic steroids. A 31-year-old woman presented with right-sided facial weakness, headache, and right ear hearing loss. On examination, redness and retraction of the right tympanic membrane and facial paresis (House-Brackman IV) were noted. Computed tomography imaging showed mastoiditis, temporal lobe stroke, and brain abscess. Magnetic resonance imaging (MRI) showed infiltration in the infratemporal fossa, nasopharynx, spreading along the Eustachian tube and perineurally along the branches of CN V and CN VII intracranially, forming a dural based mass in the middle cranial fossa. Intracranial mass compressed the temporal lobe of the brain, causing perifocal brain edema. Endoscopic biopsy of the nasopharynx was chosen as the least invasive method. It showed marked fibrosis of the tissue, dense lymphoplasmacytic infiltrates, and an increased number of IGG4-positive plasma cells. Serum IgG4 levels were below the diagnostic criteria of IgG4-RD, but histological characteristics of IgG4-RD were met. The patient was treated with high-dose oral prednisolone. Resolution of symptoms, including facial nerve paresis, was observed and infiltration in the nasopharynx, infratemporal fossa decreased on subsequent MRI tests. No recurrence was noted on the follow-up of 16 months. The case presented itself as a diagnostic challenge for a multidisciplinary team to differentiate pathology caused by either IgG4-RD, systemic vasculitis, or atypic mastoiditis. MRI and histological reports were essential to establish a correct diagnosis.
Prognostic Factor for Subacute Encephalitis with First-Episode Psychosis
Authors: Kataoka Hiroshi , Nanaura Hitoki , Kiriyama Takao , Sugie Kazuma
Published: June 2022

Introduction: Although symptomatic manifestations in encephalitis vary, they typically include seizures, memory deficit(s), and altered consciousness. Psychosis also occurs as an initial manifestation. In clinical practice, clinicians often encounter the question of whether first-episode psychosis (FEP) originates from encephalitis itself or if encephalitis presenting with FEP develops concurrently. The prognosis of FEP among patients with overall encephalitis, including autoimmune encephalitis, remains uncertain. Methods: We examined a prognostic factor in patients with encephalitis who had both FEP and CSF pleocytosis. A total of 36 patients who presented with FEP were enrolled. A score of ≥3 and ≤2 on the modified Rankin scale were defined as poor and good outcomes, respectively. A total of 13 independent variables were analyzed by the multivariate logistic regression analysis. Results: Significant variables on univariate logistic regression analysis included female sex (OR 5.571, 95% CI: 1.297–23.934; p = 0.021) and the use of mechanical ventilation during the acute stage (OR 7.286, 95% CI: 1.508–35.211; p = 0.013). On multivariate logistic regression analysis, the use of mechanical ventilation during the acute stage (OR 5.446, 95% CI: 1.044–28.615; p = 0.044) was significantly associated with poor outcomes. Conclusions: The use of mechanical ventilation is a poor prognostic factor of subacute encephalitis with FEP, and female sex may be a risk factor for unfavorable development of the disease.
Characteristics of Rosacea and Similar Diseases in Patients Wearing Face Masks
Authors: Nobeyama Yoshimasa , Aihara Yoshiko , Asahina Akihiko
Published: June 2022

Introduction: The present study aimed to obtain fundamental data, including climate conditions and Demodex mites, on rosacea and similar diseases in the situation where the wearing of face masks is mandatory due to the coronavirus disease 2019 pandemic. Methods: We enrolled 86 Japanese patients habitually wearing face masks with rosacea and similar diseases. Disease severity was assessed using the Investigator Global Assessment. The presence of Demodex mites was examined microscopically. Treatment involved acaricidal and antibiotic agents. Results: The numbers of male and female patients enrolled were 11 and 75, respectively. Among these patients, 85 (98.8%), 57 (66.3%), and 76 (88.4%) had rosacea, rosacea-like dermatitis (RLD), and demodicosis, respectively. The monthly number of patients with rosacea and demodicosis showed two peaks from May to June and in October, during which monthly mean temperature was approximately 20°C (68°F). Improvement rates in rosacea, RLD, and demodicosis were significantly higher when Demodex mites were no longer detected after treatment. Conclusion: The present results suggest that a season with a mean temperature of approximately 20°C is a risk factor for rosacea and similar diseases in individuals wearing face masks in Japan, and a decrease in Demodex mites is associated with the attenuation of symptoms.
Envelhecimento e participação social
Authors: Azevedo Mônica Cordeiro de , Gazetta Maria Luísa Barca , Salimene Arlete Camargo de Melo
Published: June 2022

O presente estudo tem como objetivo conhecer como se processa a participação social dos idosos integrantes do Programa de Atendimento Global na terceira idade da Divisão de Medicina de Reabilitação do Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo do ano de 2001. Este é um programa terapêutico que objetiva proporcionar ao idoso a melhoria da capacitação física, psicológica e social. Realizou-se pesquisa quantitativa e qualitativa baseada no Instrumento de Avaliação Social, utilizado pelas assistentes sociais da Divisão, sendo pesquisado um total de dezessete pacientes. O grupo é composto predominantemente por mulheres, que associaram os relacionamentos interpessoais à possibilidade de participação social. A vontade de estar se relacionando com outras pessoas é o principal fator que lhes motiva a procurar atividades. Constata-se que os membros deste grupo podem ser considerados participativos socialmente, segundo os conceitos de participação que sugerem ao indivíduo a busca de novas atividades e relacionamentos com a chegada da terceira idade.
Fisiologia do sistema nervoso neurovegetativo
Authors: Ribeiro Sobrinho José Brenha
Published: June 2022

Uma análise das conexões anatômicas e funcionais do sistema neurovegetativo, permite o entendimento de suas relações com os núcleos hipotalamicos e com o sistema imunitário. No presente artigo está descrito o centro neurovegetativo no córtex cerebral com as reações características deste nível - reações neurovegetativas de reforço, de acompanhamento e psíquica. Apresenta-se as áreas diencefálicas, com as conexoões talâmicas, descrevendo as influências provenientes de formação reticular. As vias e centros neurovegetativos do tronco cerebral, são estudadas a partir dos centros ortossimpático e centros parassimpáticos, relacionando-os com as vias neurovegetativas da medula. A última parte é dedicada a uma conceituação sobre o sistema neurovegetativo periférico e sua expressão clínica dentro do entendimento dos fenômenos motores e sensitivos do controle medular. O trabalho é finalizado lembrando a conexão do sistema neurovegetativo com o sistema imunitário.
Dor crônica sob a ótica dos pacientes da Escola de Postura da DMR HC FMUSP
Authors: Oliveira Erineide Souza de , Gazetta Maria Luisa Barca , Salimene Arlete Camargo de Melo
Published: June 2022

A Escola de Postura é apontada na literatura mundial, como importante meio terapêutico para amenizar as dores na coluna vertebral, melhorando a qualidade de vida das pessoas assoladas por essa afecção. Este estudo objetivou conhecer a representação social que os pacientes integrantes da Escola de Postura da DMR-HCFMUSP têm sobre a dor crônica na coluna vertebral, verificando os impactos que ocorrem em suas relações sociais. A identificação dessas construções mentais oferece subsídios aos profissionais da equipe para aprimorar o programa educativo elaborado para a Escola de Postura. O estudo foi realizado por meio de pesquisa quantitativa e qualitativa, com dados coletados com os protocolos de avaliação do serviço social da DMR, específicos para este programa. O universo da pesquisa constituiu-se de 51 pacientes que participaram da escola de postura de outubro de 2001 a abril de 2002. Constatamos que as representações sociais da dor crônica da coluna estão associadas ao isolamento social, a limitação, diminuição da capacidade de produção e da virilidade a possível perda de espaço social e profissional. Essas representações interferem significativamente na aceitação e seguimento das orientações recebidas e em compartilhar com os membros dos grupos sociais nos quais participa sua condição de “pessoa com uma doença limitante”, podendo gerar conflitos quando do desempenho de papéis sociais.
Considerações sobre o processo de reabilitação
Authors: Borgneth Livia
Published: June 2022

Este artigo propõe uma reflexão sobre o conceito do processo de reabilitação que tem por meta final a inclusão social da pessoa portadora de deficiência e a característica de dependência deste tipo de ação ao trabalho em equipe. Defende para reabilitação a atuação em equipe multiprofissional com metodologia interdisciplinar, considerando as vantagens inerentes deste tipo de organização de trabalho para incluir a pessoa portadora de deficiência na sociedade. Entende que toda equipe necessita de coordenação e ressalta a importância do papel do coordenador de equipe e a necessidade de capacitar médicos com a formação adequada para esta função. Discute as funções da equipe de reabilitação, incluindo a realização do diagnóstico funcional e a facilitação da adaptação do paciente e sua família à nova realidade, com a compreensão de suas limitações e potencialidades.
Comparação de dois tipos de mouse por meio de eletroneuromiografia de superfície
Authors: Riberto Marcelo , Lourenção Maria Inês Paes , Lopes José Augusto Fernandes
Published: June 2022

O mouse é um periférico muito usado em informática, todavia seu uso por tempo prolongado pode levar a sobrecarga da musculatura do antebraço resultados em quadros dolorosos. Este estudo teve como objetivo verificar se um novo mouse, com desenho que respeita leis biomecânicas da mão e punho, estaria associado a menor sobrecarga muscular que um modelo convencional. Vinte usuários habituais de computador sadios participaram de um estudo do tipo cross-over, no qual a atividade muscular dos músculos trapézio, extensor do carpo e flexor do polegar foi captada por meio de eletroneuromiografia de superfície durante a realização de atividades simples como jogar paciência por 10 minutos e deslocar-se numa planilha.Também foram aplicados questionários sobre aparecimento de sintomas em membros superiores após o uso de cada mouse. Por meio da integração do sinal elétrico nos períodos de tempo da captação, o esforço muscular pode ser quantificado para processamento estatístico. Apenas em extensores do carpo foi observada redução estatisticamente significante da solicitação muscular, mesmo assim, apenas ao jogar Paciência. O posicionamento do punho proporcionado pelo mouse em teste facilitou a manutenção dessa articulação em posição de preparo para o acionamento dos botões do mouse reduzindo a atividade muscular. Seu uso rotineiro pode ser uma estratégia para a prevenção de dores em membros superiores de usuários de computadores e para o controle sintomático naqueles que já apresentam alguma lesão local.
Níveis de lactato sanguíneo, em futebolistas profissionais, verificados após o primeiro e o segundo tempos em partidas de futebol
Authors: Silva Paulo Roberto Santos , Inarra Luís Antonio , Vidal José Roberto Rivelino , Oberg Alexandre Augusto Ribeiro Barros , Fonseca Junior Alcides , Roxo Carla Dal Maso Nunes , Machado Gilberto Silva , Teixeira Alberto Azevedo Alves
Published: June 2022

O objetivo desse estudo foi verificar o envolvimento do metabolismo anaeróbio lático por meio de medidas de lactato sanguíneo em futebolistas profissionais imediatamente após o término do primeiro e do segundo tempos, em partidas de futebol. Foram avaliados 26 jogadores, todos do sexo masculino e pertencentes ao Departamento de Futebol Profissional da Associação Portuguesa de Desportos de São Paulo. O grupo foi composto por 4 laterais, 13 meio-campistas e 9 atacantes. A idade variou de 18 a 33 anos, o peso de 56,5 kg a 78,5 kg e a estatura de 164 cm a 185 cm. A escolha dos futebolistas durante os procedimentos foi aleatória. Foi utilizado um analisador de lactato portátil (modelo Accusport®, Boehringer Mannheim®, GER). Os seguintes resultados foram verificados: a média de lactato em todos os jogadores verificados ao final do primeiro e do segundo tempos das partidas analisadas foi de 7,1 mM ± 0,6 mM e 5,7 mM ± 1,3 mM (p < 0,05). Quando divididos por posição, os laterais apresentaram respectivamente: 6,9 mM ± 2,9 mM e 4,7 mM ± 3,0 mM; os meiocampistas: 6,4 mM ± 1,8 mM e 5,6 mM ± 1,2 mM e os atacantes: 7,7 mM ± 1,8 mM e 7,2 ± 2,1 mM. Quando comparamos a produção de lactato pelas posições, somente houve diferença estatística significante (p < 0,05) no segundo tempo entre os atacantes 7,2 mM ± 2,1 mM e os meio-campistas 5,6 mM ± 1,2 mM, respectivamente. Conclusão: Fatores subjetivos como grau de movimentação, recuperação rápida e disposição constante na partida, relacionados a fatores primários como atividade glicolítica reduzida e a diminuição da concentração de glicogênio muscular, motivados por pouco treinamento anaeróbio lático específico e/ou uma dieta deficiente, são evidências que podem explicar, em parte, porque o lactato sanguíneo no segundo tempo tem sido freqüentemente mais baixo quando comparado ao término do primeiro tempo em uma partida de futebol.
A utilização do biofeedback no tratamento fisioterápico da paralisia facial periférica
Authors: Goulart Fátima , Vasconcelos Karina Simone de Souza , Souza Margareth Rosy Vilasboas de , Pontes Patricia Barcelos
Published: June 2022

A paralisia facial periférica (PFP) é caracterizada como uma lesão do nervo facial que altera as funções da musculatura da face podendo ser causada por fatores traumáticos, infecciosos, idiopáticos e outros. Naqueles casos que evoluem para a forma crônica, as complicações mais comuns são o ressecamento corneano e as sincinesias. Além disso, essa doença gera incapacidades físicas, psicológicas e sociais. Várias técnicas fisioterápicas foram propostas para o tratamento da PFP, porém, muitas não consideram a especificidade do sistema neuromotor facial e nenhuma se destaca como sendo a mais efetiva. Esse artigo faz uma revisão bibliográfica sobre o uso do biofeedback na PFP, ressaltando técnicas, características e efeitos do tratamento. O biofeedback é uma técnica que utiliza referências visuais ou auditivas por meio da eletromiografia, do espelho ou de outros recursos, para fornecer ao indivíduo informações sobre sua performance motora. Essa técnica associada a exercícios específicos tem sido apontado como benéfico no tratamento da PFP. Os principais efeitos alcançados são a melhora do controle e da coordenação do movimento e a redução da assimetria e sincinesia, por um processo de aprendizado motor. Fatores como início precoce, maior duração do tratamento, acompanhamento posterior e adesão dos sujeitos parecem influenciar a obtenção de resultados positivos. Apesar das inúmeras vantagens apontadas na literatura para a utilização do biofeedback na PFP, os estudos revisados não consideram a heterogeneidade dos sujeitos submetidos ao tratamento e não determinam quais características realmente alteram a recuperação dos indivíduos em tratamento com biofeedback. Além disso, os efeitos do biofeedback a longo prazo não estão estabelecidos e a manutenção de um programa domiciliar orientado parece ser necessário.