bluuebunny/crossref_metadata_2025 huggingface dataset:
What Do We Talk About Now When We Talk About Segmentectomy for GGO?
Authors: Li Hanyue , Shen Chen , Chen Yang , Wang Yiyang , Zhong Chenxi , Fang Wentao
Published: February 2022

Segmentectomy has been considered as a compromised procedure in patients with early-stage lung cancer who could not tolerate standard lobectomy. By computed tomography (CT) screening, lung cancers are increasingly detected in earlier stages, especially those appearing as ground glass opacity (GGO)-containing lesions on CT scan. This has led to the revival of segmentectomy as an intentional procedure with the aim of curing selected patients, as GGO-containing lesions represent a special group of diseases that are relatively indolent in nature and seldom have lymphatic involvement. Limited resections, especially anatomical segmentectomy, may, thus, be helpful in reducing perioperative risks and preserving higher pulmonary function for patients while retaining similar oncological outcomes. However, clinical trials focusing specifically on the role of segmentectomy in the treatment of GGO-containing lung cancers are still lacking, especially in the minimally invasive surgery setting. Emerging evidence suggests that for such lesions, the oncological non-inferiority of segmentectomy to standard lobectomymay not be limited to lesions with a size ≤ 2 cm. More importantly, it is still unclear whether segmentectomy could indeed minimize perioperative risks and to what extent it could help preserve higher pulmonary function in good-risk patients with less extent of lung parenchyma resection. Hence, it is critical to reevaluate the efficacies of minimally invasive segmentectomy including not only oncological outcomes but also perioperative results and pulmonary function changes compared with lobectomy in good-risk patients with GGO-containing lung cancers. All these remain to be explored in future studies and robust evidence is still needed to prove that patients would indeed benefit from the combination of segmentectomy and minimally invasive surgery.
Identification of CCp5 and FNPA as Novel Non-canonical Members of the CCp Protein Family in Babesia bovis
Authors: Ozubek Sezayi , Alzan Heba F. , Bastos Reginaldo G. , Laughery Jacob M. , Suarez Carlos E.
Published: February 2022

Bovine babesiosis, caused by Babesia bovis, is an economically significant tick-borne disease that imposes restrictions to livestock production worldwide. Current methods to control bovine babesiosis have severe limitations and novel approaches, including transmission-blocking vaccines, are needed. Members of the widely conserved CCp family are multidomain adhesion proteins containing LCCL motifs, which are differentially expressed on gametocytes of apicomplexans, including Babesia spp. and Plasmodium spp. While Plasmodium parasites contain 6 distinct CCp genes, only three members (CCp 1-3) were previously identified in B. bovis. In this study, we describe the identification and characterization of two novel non-canonical members of the CCp gene family in B. bovis, named CCp5 and FNPA. The genes were identified in silico by TBLASTN using P. falciparum CCp family domains as queries. Unlike CCp1-3, the B. bovis CCp5 and FNPA proteins lack the LCCL canonical domain but contain other typical multidomain adhesion motifs which are present in classical CCp proteins. In addition, the B. bovis CCp5 and FNPA are in synteny with known CCp genes in related apicomplexans. Sequence analysis of these two proteins demonstrated high sequence conservation among B. bovis different isolates. Transcription, immunoblot, and immunofluorescence analyses demonstrated expression of CCp5 and FNPA in blood and in vitro induced sexual stages of B. bovis. The FNPA, in contrast to CCp5, has a predicted transmembrane domain, suggesting that it might be expressed in the surface of sexual stage parasites. Altogether, finding of this study support FNPA as a possible target of a transmission-blocking vaccine against B. bovis.
Interleukin-10 Delays Viral Clearance in the Placenta and Uterus of Mice With Acute Lymphocytic Choriomeningitis Virus Infection During Pregnancy
Authors: Negi Vidya Devi , Khurana Sandhya , Bonney Elizabeth A.
Published: February 2022

Pregnant mice infected with Lymphocytic Choriomeningitis Virus (Armstrong) (LCMV-Arm) experience high viral loads in the placenta and uterine tissue by 5–8 days post-infection, a time when the virus is nearly completely cleared from the spleen and blood. Interleukin 10 (IL-10) plays a crucial role in T cell responses associated with systemic viral clearance. Using the LCMV-arm model of infection, we examined first, whether IL-10 is involved in viral clearance in the placenta and uterine tissue and secondly, the potential mechanisms underlying this phenomenon. C57BL/6 (WT) and mice deficient in IL-10 (IL-10 KO) were infected with LCMV-Arm on day 10 of pregnancy. Placenta and uterine tissue, collected 2 and 8 days later, were analyzed using real time RT-PCR, plaque assays for viral load, and flow cytometry. In WT mice placenta and uterine tissue expression of IL-10 was elevated with LCMV-Arm infection. Fetus resorption was elevated in WT on days 2 and 8 post-infection as compared to IL-10 KO, and by day 19 of gestation delivery was greater. Viral loads in the placenta and uterine tissue were resolved early in IL-10 KO mice, but persistent in tissues of WT mice. Levels of NRF2 and FAS were equivalent, but BCL2L11 was higher in IL-10 KO uterus. IL-6, Interferon-β (IFN-β), CCL2, and IL-17 levels were also equivalent. IL-10 KO tissues tended toward higher expression of interferon-γ (IFN-γ) and had significantly lower expression of Transforming growth factor beta (TGF-β). The proportion of placenta and uterine tissue CD8 T cells expressing the activation markers CD44hiand PD1 were elevated in IL-10 KO mice. These data suggest that high IL-10 expression at the fetal-maternal interface following LCMV-Arm infection prevents clearance of viral load by impairing CD8 T cell activation and poses a significant threat to successful pregnancy outcome. The ability to modulate IL-10 expression at the maternal-fetal interface may help overcome negative pregnancy outcomes arising during acute LCMV and other viral infections in humans.
Molecular Insights of SARS-CoV-2 Antivirals Administration: A Balance between Safety Profiles and Impact on Cardiovascular Phenotypes
Authors: Nappi Francesco , Iervolino Adelaide , Avtaar Singh Sanjeet Singh
Published: February 2022

The COVID-19 pandemic has resulted in a complex clinical challenge, caused by a novel coronavirus, partially similar to previously known coronaviruses but with a different pattern of contagiousness, complications, and mortality. Since its global spread, several therapeutic agents have been developed to address the heterogeneous disease treatment, in terms of severity, hospital or outpatient management, and pre-existing clinical conditions. To better understand the rationale of new or old repurposed medications, the structure and host–virus interaction molecular bases are presented. The recommended agents by EDSA guidelines comprise of corticosteroids, JAK-targeting monoclonal antibodies, IL-6 inhibitors, and antivirals, some of them showing narrow indications due to the lack of large population trials and statistical power. The aim of this review is to present FDA-approved or authorized for emergency use antivirals, namely remdesivir, molnupinavir, and the combination nirmatrelvir-ritonavir and their impact on the cardiovascular system. We reviewed the literature for metanalyses, randomized clinical trials, and case reports and found positive associations between remdesivir and ritonavir administration at therapeutic doses and changes in cardiac conduction, relatable to their previously known pro-arrhythmogenic effects and important ritonavir interactions with cardioactive medications including antiplatelets, anti-arrhythmic agents, and lipid-lowering drugs, possibly interfering with pre-existing therapeutic regimens. Nonetheless, safety profiles of antivirals are largely questioned and addressed by health agencies, in consideration of COVID-19 cardiac and pro-thrombotic complications generally experienced by predisposed subjects. Our advice is to continuously adhere to the strict indications of FDA documents, monitor the possible side effects of antivirals, and increase physicians’ awareness on the co-administration of antivirals and cardiovascular-relevant medications. This review dissects the global and local tendency to structure patient-based treatment plans, for a glance towards practical application of precision medicine.
Uremic Toxin Lanthionine Induces Endothelial Cell Mineralization In Vitro
Authors: Coppola Annapaola , Vigorito Carmela , Lombari Patrizia , Martínez Yuselys García , Borriello Margherita , Trepiccione Francesco , Ingrosso Diego , Perna Alessandra F.
Published: February 2022

Vascular calcification (VC) is a pathological event caused by the unusual deposition of minerals in the vascular system, representing the leading cause of cardiovascular mortality in chronic kidney disease (CKD). In CKD, the deregulation of calcium and phosphate metabolism, along with the effect of several uremic toxins, act as key processes conveying altered mineralization. In this work, we tested the ability of lanthionine, a novel uremic toxin, to promote calcification in human endothelial cell cultures (Ea.hy926). We evaluated the effects of lanthionine, at a concentration similar to that actually detected in CKD patients, alone and under pro-calcifying culture conditions using calcium and phosphate. In pro-calcific culture conditions, lanthionine increased both the intracellular and extracellular calcium content and induced the expression of Bone Morphogenetic Protein 2 (BMP2) and RUNX Family Transcription Factor 2 (RUNX2). Lanthionine treatment, in pro-calcifying conditions, raised levels of tissue-nonspecific alkaline phosphatase (ALPL), whose expression also overlapped with Dickkopf WNT Signaling Pathway Inhibitor 1 (DKK1) gene expression, suggesting a possible role of the latter gene in the activation of ALPL. In addition, treatment with lanthionine alone or in combination with calcium and phosphate reduced Inorganic Pyrophosphate Transport Regulator (ANKH) gene expression, a protective factor toward the mineralizing process. Moreover, lanthionine in a pro-calcifying condition induced the activation of ERK1/2, which is not associated with an increase in DKK1 protein levels. Our data underscored a link between mineral disease and the alterations of sulfur amino acid metabolisms at a cell and molecular level. These results set the basis for the understanding of the link between uremic toxins and mineral-bone disorder during CKD progression.
Underwater Attachment of the Water-Lily Leaf Beetle Galerucella nymphaeae (Coleoptera, Chrysomelidae)
Authors: Grohmann Constanze , Cohrs Anna-Lisa , Gorb Stanislav N.
Published: February 2022

While the reversible attachment of artificial structures underwater has moved into the focus of many recent publications, the ability of organisms to walk on and attach to surfaces underwater remains almost unstudied. Here, we describe the behaviour of the water-lily leaf beetle Galerucella nymphaeae when it adheres to surfaces underwater and compare its attachment properties on hydrophilic and hydrophobic surfaces underwater and in the air. The beetles remained attached to horizontal leaves underwater for a few minutes and then detached. When the leaf was inclined, the beetles started to move upward immediately. There was no difference in the size of the tarsal air bubble visible beneath the beetles’ tarsi underwater, between a hydrophilic (54° contact angle of water) and a hydrophobic (99°) surface. The beetles gained the highest traction forces on a hydrophilic surface in the air, the lowest on a hydrophobic surface in air, and intermediate traction on both surfaces underwater. The forces measured on both surfaces underwater did not differ significantly. We discuss factors responsible for the observed effects and conclude that capillary forces on the tarsal air bubble might play a major role in the adhesion to the studied surfaces.
New Frontiers in Management of Early and Advanced Rectal Cancer
Authors: Wlodarczyk Jordan R. , Lee Sang W.
Published: February 2022

It is important to understand advances in treatment options for rectal cancer. We attempt to highlight advances in rectal cancer treatment in the form of a systematic review. Early-stage rectal cancer focuses on minimally invasive endoluminal surgery, with importance placed on patient selection as the driving factor for improved outcomes. To achieve a complete pathologic response, various neoadjuvant chemoradiation regimens have been employed. Short-course radiation therapy, total neoadjuvant chemotherapy, and others provide unique advantages with select patient populations best suited for each. With a clinical complete response, a “watch and wait” non-operative surveillance has been introduced with preliminary equivalency to radical resection. Various modalities for total mesorectal excision, such as robotic or transanal, have advantages and can be utilized in select patient populations. Tumors demonstrating solid organ or peritoneal spread, traditionally defined as unresectable lesions conveying a terminal diagnosis, have recently undergone advances in hepatic and pulmonary metastasectomy. Hepatic and pulmonary metastasectomy has demonstrated clear advantages in 5-year survival over standard chemotherapy. With the peritoneal spread of colorectal cancer, HIPEC with cytoreductive therapy has emerged as the preferred treatment. Understanding the various therapeutic interventions will pave the way for improved patient outcomes.
Enhancing Joint Attention Skills in Children on the Autism Spectrum through an Augmented Reality Technology-Mediated Intervention
Authors: Pérez-Fuster Patricia , Herrera Gerardo , Kossyvaki Lila , Ferrer Antonio
Published: February 2022

In the present study, the effects of an intervention based on an augmented reality technology called Pictogram Room were examined. The objective of the intervention was to improve the responding to joint attention (RJA) skills of gaze following and pointing in six children on the autism spectrum between 3 and 8 years old. A multiple baseline single-subject experimental design was conducted for 12 weeks in a school setting. Results indicated that all of the participant children improved performance in RJA following the intervention. Improvements were maintained over time and generalised to real-world situations. These findings demonstrate that autistic children can improve their RJA skills with a targeted and engaging intervention based on an accessible augmented reality technology tool.
A Searchable Encryption Scheme with Biometric Authentication and Authorization for Cloud Environments
Authors: Mihailescu Marius Iulian , Nita Stefania Loredana
Published: February 2022

Cloud computing offers the possibility of providing suitable access within a network for a set of resources. Many users use different services for outsourcing their data within the cloud, saving and mitigating the local storage and other resources involved. One of the biggest concerns is represented by storing sensitive data on remote servers, which can be found to be extremely challenging within different situations related to privacy. Searchable Encryption (SE) represents a particular case of Fully Homomorphic Encryption (FHE) and at the same time represents a method composed from a set of algorithms meant to offer protection for users’ sensitive data, while it preserves the searching functionality on the server-side. There are two main types of SE: Searchable Symmetric Encryption (SSE), where the ciphertexts and trapdoors for searching are performed using private key holders, and Public Key Searchable Encryption (PKSE), in which a specific number of users have the public key based on which are capable of outputting ciphertexts and giving the possibility of producing the trapdoors by using the private key from the holder. In this article, we propose a searchable encryption system that uses biometric authentication. Additionally, biometric data are used in the trapdoor generation process, such that an unauthorized user cannot submit search queries. The proposed system contains three components: classic user authentication (based on username, password, and a message with a code using short message service (SMS), biometric authentication, and the searchable encryption scheme. The first two components can be seen as two-factor authentication (2FA), and the second component represents the initialization step of the searchable encryption scheme. In the end, we show and demonstrate that the proposed scheme can be implemented with success for medium to complex network infrastructures. We have granted special attention to the trapdoor function, which generates a value that can be used to perform the search process and search function that is based on the trapdoor pair for searching within the index structure. We provide the correctness and security proof of the operations, which gives us the guarantee that the cloud servers return the correct documents. Additionally, we discuss measuring the performance of the authentication scheme in terms of performance indicators, introducing two indicators for measuring purposes—namely, cloud average number of non-legitim the user actions for cloud purposes (CANNL) and cloud average number of legitim user actionsCANLU.
Comprehensive Performance Evaluation of Densified Liquid Hydrogen/Liquid Oxygen as Propulsion Fuel
Authors: Xie Fushou , Sun Qiang
Published: February 2022

Densified liquid hydrogen/liquid oxygen is a promising propulsion fuel in the future. In order to systematically demonstrate the benefits and challenges of densified liquid hydrogen/liquid oxygen, a transient thermodynamical model considering the heat leakage, temperature rise, engine thrust, pressurization pressure of the tank, and wall thickness of tank is developed in the present paper, and the performance of densified liquid hydrogen/liquid oxygen as propulsion fuel is further evaluated in actual application. For liquid hydrogen/liquid oxygen tanks at different structural dimensions, the effects of many factors such as temperature rise during propellant ground parking, lift of engine thrust, mass reduction of the tank structure, and extension of spacecraft in-orbit time are analyzed to demonstrate the comprehensive performance of liquid hydrogen/liquid oxygen after densification. Meanwhile, the problem of subcooling combination matching of liquid hydrogen/liquid oxygen is proposed for the first time. Combining the fuel consumption and engine thrust lifting, the subcooling combination matching of liquid hydrogen/liquid oxygen at different mixing ratios and constant mixing ratios are discussed, respectively. The results show that the relative engine thrust enhances by 6.96% compared with the normal boiling point state in the condition of slush hydrogen with 50% solid content and enough liquid oxygen. The in-orbit time of spacecraft can extend about 2–6.5 days and 24–95 days for slush hydrogen with 50% solid content and liquid oxygen in the triple point state in different cryogenic tanks, respectively. Due to temperature rise during parking, the existing adiabatic storage scheme and filling scheme for densification LH2 need to be redesigned, and for densification LO2 are suitable. It is found that there is an optimal subcooling matching relation after densification of liquid hydrogen/liquid oxygen as propulsion fuel. In other words, the subcooling temperature of liquid hydrogen/liquid oxygen is not the lower the better, but the matching relationship between LH2 subcooling degree and LO2 subcooling degree needs to be considered at the same time. It is necessary that the LO2 was cooled to 69.2 K and 54.5 K, when the LH2 of 13.9 K and SH2 with 45% was adopted, respectively. This research provides theoretical support for the promotion and application of densification cryogenic propellants.
High-Voltage Cable Condition Assessment Method Based on Multi-Source Data Analysis
Authors: Meng Xiao-Kai , Jia Yan-Bing , Liu Zhi-Heng , Yu Zhi-Qiang , Han Pei-Jie , Lu Zhu-Mao , Jin Tao
Published: February 2022

In view of the problem that the weight value given by the previous state evaluation method is fixed and single and cannot analyze the influence of the weight vector deviation on the evaluation result, a method based on the weight space Markov chain and Monte Carlo method (Markov chains Monte Carlo, MCMC) is proposed. The sampling method is used for evaluating the condition of high-voltage cables. The weight vector set obtained by MCMC sampling and the comprehensive degradation degree of the high-voltage cable sample are weighted and summed then compared in pairs to obtain the comprehensive degradation degree result. The status probability value and overall priority ranking probability of the object to be evaluated are obtained based on probability statistics, and the order of maintenance is determined according to the status probability value and the ranking result. It is realized that the cable line that needs to be identified in the follow-up defect is clarified according to the evaluation result. This is helpful for operational and maintenance personnel to more accurately implement the maintenance plan for the cable and improve the operational and maintenance efficiency.
Potential Greenhouse Gas Mitigation for Converting High Moisture Food Waste into Bio-Coal from Hydrothermal Carbonisation in India, Europe and China
Authors: Davison Nicholas , Borbolla Gaxiola Jaime , Gupta Divya , Garg Anurag , Cockerill Timothy , Tang Yuzhou , Yuan Xueliang , Ross Andrew
Published: February 2022

Hydrothermal carbonisation is a promising technology for greenhouse gas (GHG) mitigation through landfill avoidance and power generation, as it can convert high-moisture wastes into bio-coal which can be used for coal substitution. The GHG mitigation potential associated with landfill avoidance of high-moisture food waste (FW) generated in India, China and the EU was calculated and the potential for coal substitution to replace either grid energy, hard coal, or lignite consumption were determined. Different HTC processing conditions were evaluated including temperature and residence times and their effect on energy consumption and energy recovery. The greatest mitigation potential was observed at lower HTC temperatures and shorter residence times with the bio-coal replacing lignite. China had the greatest total mitigation potential (194 MT CO2 eq), whereas India had the greatest mitigation per kg of FW (1.2 kgCO2/kg FW). Significant proportions of overall lignite consumption could be substituted in India (12.4%) and China (7.1%), while sizable levels of methane could be mitigated in India (12.5%), China (19.3%), and the EU (7.2%). GHG savings from conversion of high-moisture FW into bio-coal and subsequent coal replacement has significant potential for reducing total GHG emissions and represents in India (3%), China (2.4%), and the EU (1%).
Petroleum Charging History of the Paleogene Sandstone Reservoirs in the Huangtong Sag of the Fushan Depression, South China Sea
Authors: Wang Xin , Lu Zhenghuan , Li Meijun , Guo Hao , Zhu Zhili , Li Xiaohan , Yang Chengyu , Zeng Bang , Wang Fangzheng , Ran Zichao
Published: February 2022

The Paleogene sandstone reservoir in the Huangtong Sag of the Fushan Depression is one of the most commercially prolific oil accumulations in the Beibuwan Basin, South China Sea. In this study, twenty-seven crude oil samples from four oilfields in the sag were geochemically analyzed and classified into three oil groups. Oils in the Meitai and Hongguang oilfields show similar geochemical characteristics, with relatively abundant C30 4α-methyl-24-ethylcholestanes and low contents of oleanane and C19+20 tricyclic terpanes (TT), and therefore may be derived from the same source kitchen. Oils from the Yong’an oilfield have a greater proportion of oleanane and C19+20 TT compounds. Oils from the Chaoyang oilfield have intermediate contents of these biomarkers and proportionate values of other related parameters. The unimodal distribution pattern of homogenization temperatures of fluid inclusions found in all the Paleogene reservoirs indicates a single episode of charging. Combining this understanding with the reconstruction of stratigraphy-burial and geothermal histories by 1-D basin modeling, the petroleum charging time was determined to be between 8–2 Ma (the end of the middle Miocene to the early Pliocene). Hydrocarbon migration orientation and charging pathways were traced using molecular indicators (4-/1-methyldibenzothiophene and 1-/4-methodibenzofuran). In the Chaoyang oilfield, the values of these geochemical parameters decreased with decreasing burial depth, indicating vertical oil migration along faults, which are plentiful in the sag. Sandstone bodies with deeper burial depths may therefore be the most promising exploration targets in the Chaoyang area. The Yong’an oils generally migrate from the northwest toward the southeast, suggesting that the source kitchen for the Yong’an oilfield is in the northwest. By similar inference, the hydrocarbon source kitchen for the Hongguang-Meitai area is likely to be on the north side of the Hongguang-Meitai area. By tracing these hydrocarbon charging pathways, the northwest of the Yong’an area and the northern part of the Hongguang-Meitai area are identified as the most promising areas for exploration.
Modeling of a Grid-Independent Set-Up of a PV/SOFC Micro-CHP System Combined with a Seasonal Energy Storage for Residential Applications
Authors: Ghanem Rahaf S. , Nousch Laura , Richter Maria
Published: February 2022

Renewable energy sources based on solar and wind energy provide clean and efficient energy. The intermittent behaviour of these sources is challenging. At the same time, the needs for efficient, continuous and clean energy sources are increased for serving both electricity and thermal demands for residential buildings. Consequently, complimentary systems are essential in order to ensure a continuous power generation. One of the promising energy sources that helps in reducing CO2 emissions, in addition to providing electrical and thermal energy efficiently, is a Solid Oxide Fuel Cell (SOFC) system operated in a combined heat and power (CHP) mode, due to high electrical efficiencies (in full and part load) and the fuel flexibility. Currently, most studies tend to focus on fuel cell model details with basic information about the building’s energy requirements. Nevertheless, a deep understanding of integrating fuel cell micro-CHP systems with renewable energy systems for the residential sector is required. Moreover, it is important to define an operating strategy for the system with a specific controlling method. This helps in evaluating the performance and the efficiency of the building energy system. In this study, an investigation of different configurations of a hybrid power system (HPS) was carried out. The intended aim of this investigation was to optimize a HPS with minimal CO2 emissions, serving the energy demands for a single-family house efficiently and continuously. As a result of this study, a photovoltaic (PV)/SOFC micro-CHP system has satisfied the intended goal, where the CO2 emissions are significantly reduced by 88.6% compared to conventional systems. The SOFC micro-CHP plant operated as a complimentary back-up generator that serves the energy demands during the absence of the solar energy. Integrating the Power to Gas (PtG) technology leads to a similar emission reduction, while the PtG plant provided a seasonal energy storage. The excess energy produced during summer by the PV system is stored in the fuel storage for a later use (during winter). This SOFC micro-CHP configuration is recommended from an energy and environmental perspective. In terms of feasibility, the costs of SOFC based micro-CHP systems are significantly higher than traditional technologies. However, further technology developments and the effect of economy of scale may cause a substantial drop in costs and the micro-CHP shall become economically competitive and available for residential users; thus, enabling a self-sufficient and efficient energy production on site.
A Comprehensive Review on Efficiency Enhancement of Solar Collectors Using Hybrid Nanofluids
Authors: Mahamude Abu , Kamarulzaman Muhamad , Harun Wan , Kadirgama Kumaran , Ramasamy Devarajan , Farhana Kaniz , Bakar Rosli , Yusaf Talal , Subramanion Sivarao , Yousif Belal
Published: February 2022

Because of its potential to directly transform solar energy into heat and energy, without harmful environmental effects such as greenhouse gas emissions. Hybrid nanofluid is an efficient way to improve the thermal efficiency of solar systems using a possible heat transfer fluid with superior thermo-physical properties. The object of this paper is the study the latest developments in hybrid applications in the fields of solar energy systems in different solar collectors. Hybrid nanofluids are potential fluids with better thermo-physical properties and heat transfer efficiency than conventional heat transfer fluids (oil, water, ethylene glycol) with single nanoparticle nanofluids. The research found that a single nanofluid can be replaced by a hybrid nanofluid because it enhances heat transfer. This work presented the recent developments in hybrid nanofluid preparation methods, stability factors, thermal improvement methods, current applications, and some mathematical regression analysis which is directly related to the efficiency enhancement of solar collector. This literature revealed that hybrid nanofluids have a great opportunity to enhance the efficiency of solar collector due to their noble thermophysical properties in replace of conventional heat transfer working fluids. Finally, some important problems are addressed, which must be solved for future study.
Virtual In Situ Calibration for Operational Backup Virtual Sensors in Building Energy Systems
Authors: Koo Jabeom , Yoon Sungmin , Kim Joowook
Published: February 2022

Intelligent building systems require a data-rich environment. Virtual sensors can provide informative and reliable sensing environments for operational datasets in building systems. In particular, backup virtual sensors that are in situ are beneficial for developing the counterparts of target physical sensors in the field, thus providing additional information about residuals between both types of sensors for use in data-driven modeling, analytics, and diagnostics. Therefore, to obtain virtual sensor potentials continuously during operation, we proposed an in situ calibration method for in situ backup virtual sensors (IBVS) in operational building energy systems, based on virtual in situ calibration (VIC). The proposed method was applied using operational datasets measured by a building automation system built into a target system. In a case study, the in situ virtual sensor showed large errors (the root mean squared error (RMSE) was 0.97 °C) on certain days. After conducting the proposed VIC, the RMSE of virtual sensor errors decreased by 22.7% and 18.7% from the perspective of sensor error types such as bias and random error, respectively, in the validation month. The subsequent virtual measurements could be considerably and effectively improved without retraining the specific in situ backup virtual sensor.
Electronically Controlled Power-Law Filters Realizations
Authors: Tsouvalas Errikos , Kapoulea Stavroula , Psychalinos Costas , Elwakil Ahmed S. , Jurišić Dražen
Published: February 2022

A generalized structure that is capable of implementing power-law filters derived from 1st and 2nd-order mother filter functions is presented in this work. This is achieved thanks to the employment of Operational Transconductance Amplifiers (OTAs) as active elements, because of the electronic tuning capability of their transconductance parameter. Appropriate design examples are provided and the performance of the introduced structure is evaluated through simulation results using the Cadence Integrated Circuits (IC) design suite and Metal Oxide Semiconductor (MOS) transistors models available from the Austria Mikro Systeme (AMS) 0.35 μm Complementary Metal Oxide Semiconductor (CMOS) process.
Regenerative Activities of ROS-Modulating Trace Metals in Subcutaneously Implanted Biodegradable Cryogel
Authors: Yergeshov Abdulla A. , Zoughaib Mohamed , Ishkaeva Rezeda A. , Savina Irina N. , Abdullin Timur I.
Published: February 2022

Divalent trace metals (TM), especially copper (Cu), cobalt (Co) and zinc (Zn), are recognized as essential microelements for tissue homeostasis and regeneration. To achieve a balance between therapeutic activity and safety of administered TMs, effective gel formulations of TMs with elucidated regenerative mechanisms are required. We studied in vitro and in vivo effects of biodegradable macroporous cryogels doped with Cu, Co or Zn in a controllable manner. The extracellular ROS generation by metal dopants was assessed and compared with the intracellular effect of soluble TMs. The stimulating ability of TMs in the cryogels for cell proliferation, differentiation and cytokine/growth factor biosynthesis was characterized using HSF and HUVEC primary human cells. Multiple responses of host tissues to the TM-doped cryogels upon subcutaneous implantation were characterized taking into account the rate of biodegradation, production of HIF-1α/matrix metalloproteinases and the appearance of immune cells. Cu and Zn dopants did not disturb the intact skin organization while inducing specific stimulating effects on different skin structures, including vasculature, whereas Co dopant caused a significant reorganization of skin layers, the appearance of multinucleated giant cells, along with intense angiogenesis in the dermis. The results specify and compare the prooxidant and regenerative potential of Cu, Co and Zn-doped biodegradable cryogels and are of particular interest for the development of advanced bioinductive hydrogel materials for controlling angiogenesis and soft tissue growth.
A Note on the Economics of Fruit Wines: State of the Arts and Research Gaps
Authors: Onofri Laura
Published: February 2022

The paper presents a critical survey for spurring research on the economics of fruit wines. The study performs a bibliometric and content analysis on around 6000 articles on fruit wines for a double purpose. First, the paper aims to describe the state of the art of research, including economic research, on fruit wines. Second, focusing on economic research, the paper wants to highlight and critically discuss the gaps that need to be addressed by research in the economics of fruit wines. The main results of the analysis suggest that economic research on fruit wines, different from economic research on grape wines, are very limited in the number of publications and fields/methods of application, except for the economics of apple cider wine. The main paper contributions are (1) informative about the current state of the arts of research on fruit wines and (2) propositional concerning developing economic research that analyzes key market aspects, like production and consumption patterns, price formation, market failures, and distortions, and possible corrections and remedies. The analysis of those aspects represents stimulating research and can provide important insights for strategies and policymaking.
Ultra-High Frequency Distortion Product Otoacoustic Emissions for Detection of Hearing Loss and Tinnitus
Authors: Jedrzejczak W. Wiktor , Pilka Edyta , Ganc Malgorzata , Kochanek Krzysztof , Skarzynski Henryk
Published: February 2022

Several studies have suggested that distortion product otoacoustic emissions (DPOAEs) may be an early marker not only of hearing loss (HL) but also of tinnitus. The purpose of this study was to investigate whether DPOAEs measured up to 16 kHz are affected by the presence of tinnitus. Pure tone thresholds and DPOAEs were measured in two groups: 55 patients with tinnitus and 63 subjects without tinnitus. The subjects were divided into three groups according to their audiometric results—better than 25 dB HL at all tested frequencies from 0.125 to 16 kHz, better than 25 dB up to 8 kHz, and hearing impaired. Receiver operator characteristics (ROCs) were used to test whether DPOAEs could differentiate between normal hearing, hearing loss, and tinnitus. Comparison of tinnitus subjects with the control group, matched accurately according to thresholds, did not yield any significant difference in DPOAEs. However, in both these groups hearing loss was accompanied by a decrease in DPOAEs, specifically, at 2–6 kHz and 16 kHz. The results suggest that any decrease in DPOAEs seems to be related only to hearing loss and there is no additional effect from tinnitus.
Hemostatic Responses to Multiple Bouts of Firefighting Activity: Female vs. Male Differences in a High Demand, High Performance Occupation
Authors: Smith Denise L. , Horn Gavin P. , Petruzzello Steven J. , Freund Gregory G. , Bloom Samuel I. , Fernhall Bo
Published: February 2022

While the fire service has long been a male-dominated occupation, women’s participation in this strenuous, high risk, high performance activity has increased in recent years. Firefighting induces significant cardiovascular strain, including hemostatic disruption; however, the effect of sex on hemostatic responses has not been investigated despite evidence that there are sex-related differences in hemostatic variables at rest and following exercise. Thus, we investigated hemostatic responses in age- and BMI-matched male and female firefighters who performed 3–4 evolutions of firefighting drills over a 3 h period. Venous blood samples were collected before and after the firefighting training drills and hemostatic variables were assessed. Firefighting significantly increased platelet count and factor VIII, tissue plasminogen activator (t-PA) antigen, and t-PA activity, and decreased activated partial thromboplastin time and plasminogen activator inhibitor (PAI-1) activity. Females had lower values for epinephrine-induced platelet closure time, antithrombin III, PAI-1 activity, and PAI-1 antigen. There were no interactions between sex and time for any variables assessed. In conclusion, multiple bouts of firefighting activity resulted in a procoagulatory state. Although there were sex differences for several hemostatic variables, male and female firefighters did not differ in their hemostatic response to multiple bouts of firefighting.
High-Heat Days and Presentations to Emergency Departments in Regional Victoria, Australia
Authors: Adams Jessie , Brumby Susan , Kloot Kate , Baker Tim , Mohebbi Mohammadreza
Published: February 2022

Heat kills more Australians than any other natural disaster. Previous Australian research has identified increases in Emergency Department presentations in capital cities; however, little research has examined the effects of heat in rural/regional locations. This retrospective cohort study aimed to determine if Emergency Department (ED) presentations across the south-west region of Victoria, Australia, increased on high-heat days (1 February 2017 to 31 January 2020) using the Rural Acute Hospital Data Register (RAHDaR). The study also explored differences in presentations between farming towns and non-farming towns. High-heat days were defined as days over the 95th temperature percentile. International Statistical Classification of Diseases and Related Health Problems, Tenth Revision, Australian Modification (ICD-10-AM) codes associated with heat-related illness were identified from previous studies. As the region has a large agricultural sector, a framework was developed to identify towns estimated to have 70% or more of the population involved in farming. Overall, there were 61,631 presentations from individuals residing in the nine Local Government Areas. Of these presentations, 3064 (5.0%) were on days of high-heat, and 58,567 (95.0%) were of days of non-high-heat. Unlike previous metropolitan studies, ED presentations in rural south-west Victoria decrease on high-heat days. This decrease was more prominent in the farming cohort; a potential explanation for this may be behavioural adaption.
Meeting the 24-Hour Movement Guidelines and Outcomes in Adolescents with ADHD: A Cross-Sectional Observational Study
Authors: Wang Wei , Haegele Justin A. , Wu Yandan , Li Chunxiao
Published: February 2022

According to the 24-Hour Movement Guidelines, meeting daily recommendations for physical activity, sleep, and screen time is important for obtaining optimal health benefits. This cross-sectional observational study aimed to examine (a) the prevalence of meeting the movement guidelines; and (b) the associations between meeting the guidelines and selected outcomes in adolescents with attention-deficit/hyperactivity disorder (ADHD). Data from the 2018–2019 National Survey for Children’s Health dataset was used. Participants were adolescents (10–17 years) with ADHD and without other chronic conditions. Outcomes were flourishing, school engagement, and body weight status. Exposures of interest were adherence to the movement guidelines. The frequency of the participants’ adherence to the guidelines was estimated, and regression analyses were conducted to examine the associations between adherence to the guidelines and outcomes, adjusting for potential confounders. Complete observations were available for 634 adolescents with ADHD. Overall, 46.8% of the participants met at least one movement guideline, but only 6.5% met all three. The number of guidelines met had a significant and positive association with flourishing and school engagement (β = 0.21/0.17, ptrend < 0.001). Compared with meeting all three guidelines, significant associations with lower flourishing levels were found in participants who met none, sleep only, and sedentary time only (β = −0.38–−0.13, p < 0.05). Similar findings were identified in the school engagement outcome. Adherence to the guidelines was, however, not significantly associated with the odds of being overweight or obese. Collectively, the findings suggest the movement guidelines may be appropriate for extending to adolescents with ADHD and there is a need to increase adherence to the guidelines in this group.
Etanercept Prevents Endothelial Dysfunction in Cafeteria Diet-Fed Rats
Authors: Răzvan-Valentin Scăunaşu , Güler Sertaç Ata , Utkan Tijen , Şahin Tuğçe Demirtaş , Gacar Gulcin , Yazir Yusufhan , Rencber Selenay Furat , Mircea Lupușoru , Cristian Bălălău , Bogdan Popescu , Utkan Nihat Zafer
Published: February 2022

Obesity is associated with endothelial dysfunction and this relationship is probably mediated in part by inflammation. Objective: The current study evaluated the effects of etanercept, a tumor necrosis factor-alpha (TNF-α) inhibitor, on endothelial and vascular reactivity, endothelial nitric oxide synthase (eNOS) immunoreactivity, and serum and aortic concentrations of TNF-α in a diet-induced rat model. Design and results: Male weanling Wistar rats were exposed to a standard diet and cafeteria diet (CD) for 12 weeks and etanercept was administered during CD treatment. Isolated aortas of the rats were used for isometric tension recording. Carbachol-induced relaxant responses were impaired in CD-fed rats, while etanercept treatment improved these endothelium-dependent relaxations. No significant change was observed in papaverine- and sodium nitroprusside (SNP)-induced relaxant responses. eNOS expression decreased in CD-fed rats, but no change was observed between etanercept-treated CD-fed rats and control rats. CD significantly increased both the serum and the aortic levels of TNF-α, while etanercept treatment suppressed these elevated levels. CD resulted in a significant increase in the body weight of the rats. Etanercept-treated (ETA) CD-fed rats gained less weight than both CD-fed and control rats.
What Is the Effect of Cultural Greenway Projects in High-Density Urban Municipalities? Assessing the Public Living Desire near the Cultural Greenway in Central Beijing
Authors: Xu Haiyun , Fu Fan , Miao Meng
Published: February 2022

Cultural greenway projects (CGPs) are widely regarded as an urban planning approach which connects open green spaces and sites of sociocultural value to provide access to living, working and recreational spaces and enhance local social well-being. This paper examines the impact of such CGPs on public living desire before and after a given project is completed through analyzing housing prices in the surrounding area. We deployed a hedonic pricing model (HPM) and differences in differences (DID) model to analyze and record any changes in housing market trends that may have been caused by such a cultural greenway project. Via analysis of single-family home sale transactions in central Beijing from 2013 to 2017, we found substantial evidence that proximity to a cultural greenway project is positively linked with rising property prices. Once complete, CGPs were similarly associated with positive increases per HPM and DID modeling. Our results revealed that the distance to greenway contributed significantly positive impact on the housing market after the cultural greenway project completed. Moreover, our result indicated that once a CGP was open to the public, it increased the price of properties within 1 km by 13.3%. Seller and buyer expectations of the development of local, green public infrastructure also began to factor into housing prices prior to the greenway opening to the public. Post-completion, the positive trend in property pricing due to local CGPs indicates that the public still have an increasing desire to live near the greenway. These results will help policymakers better understand how cultural greenways affect neighborhoods in high-density urban contexts, and will support the development of urban greenway policies for cities in China that reap the maximum economic benefit.
A Qualitative Exploration of Stakeholder Involvement in Decision-Making for Alcohol Treatment and Prevention Services
Authors: Alderson Hayley , Kaner Eileen , O’Donnell Amy , Bate Angela
Published: February 2022

The concept of providing individuals with a ‘voice’ via stakeholder involvement has been advocated within English health care policy for several decades. Stakeholder involvement encourages people affected by an issue to contribute to planning and decision making regarding treatment and care, inclusive of providers and recipients of care. This paper explores stakeholder involvement in the design and delivery of public health alcohol services. A qualitative case study approach was adopted, including in-depth interviews with 11 alcohol commissioners, 10 alcohol service providers and 6 general practitioners plus three facilitated focus groups with 31 alcohol service users. Findings show that most participants were aware of, and could name, various methods of stakeholder involvement that they had engaged with; however, the extent and impact of stakeholder involvement in decision making are not transparent. It is essential that a deeper understanding is generated of the different roles that stakeholders can play within the entire decision-making process to maximise its utility.