bluuebunny/crossref_metadata_2025 huggingface dataset:
eHealth tools to assess neurological function: a systematic review protocol for a mapping exercise
Authors: Ferreira Vasco Ribeiro , Seddighi Hamed , Beumeler Lise , Metting Esther , Gallo Valentina
Published: September 2022

Introduction

Population-based epidemiological studies investigating risk/protective factors are outlining prevention strategies for neurological conditions that often do not have effective treatment. However, ascertaining neurological outcomes can be a time consuming and expensive process, often requiring specialised personnel and/or equipment. Thus, collecting neurological data on a large scale has been an ongoing challenge for clinicians and researchers alike. The development of new technology and the emergence of several opportunities to adapt it to the health research and practice (eHealth) can be a promising solution to this problem. Several neurological eHealth tools have been developed, with many others being currently planned.

Methods and analysis

We propose a systematic review mapping the available eHealth tools for assessing the different aspects of neurological function. The search aims at identifying studies published in peer-reviewed journals, which focused on the development or implementation of eHealth for assessing neurological signs or symptoms. Four engine databases are being considered (PubMed, EBSCOhost, Web of Science and Scopus), and data extraction will follow a process aimed at classifying them by their characteristics and purposes.

Ethics and dissemination

This mapping exercise will be made available to researchers in order to aid them in successfully ascertaining neurological outcomes in large population-based epidemiological studies. Given the nature of this study, no ethical clearance was needed to conduct the review.
Comparative cardiovascular side effects of medications for attention-deficit/hyperactivity disorder in children, adolescents and adults: protocol for a systematic review and network meta-analysis
Authors: Lannes Alice , Farhat Luis C , Del Giovane Cinzia , Cipriani Andrea , Revet Alexis , Cortese Samuele
Published: September 2022

Introduction

Pharmacotherapy is an important component of the multimodal treatment of attention-deficit/hyperactivity disorder (ADHD). Cardiovascular safety of medications for ADHD is of concern from a clinical and public health standpoint. We aim to conduct a network meta-analysis (NMA) comparing the effects of available medications for ADHD on blood pressure (diastolic and systolic), heart rate and ECG parameters over the short-term and long-term treatment.

Methods and analysis

Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines for protocols and NMAs will be followed. We will include parallel group or cross-over randomised controlled trials (RCTs) conducted in patients with a primary diagnosis of ADHD (no age limits). We will search an extensive number of electronic databases (including MEDLINE, CINAHL, CENTRAL, EMBASE, ERIC, PsycINFO, OpenGrey, Web of Science) from their inception and contact study authors/drug manufacturers to gather relevant unpublished information. No language restrictions will be applied. The main outcomes (assessed at 12 weeks, 26 weeks and 52 weeks) will be: (1) change in diastolic and systolic blood pressure (mm Hg); (2) change in heart rate, measured in beats/min; (3) change in any available ECG parameters. We will conduct random effects of NMA using standardised mean differences with 95% CIs for continuous outcomes and ORs with 95% CIs for dichotomous outcomes. We will use the Cochrane risk of bias tool-version 2 to assess the risk of bias of included RCTs and the Confidence In Network Meta-Analysis tool to evaluate the confidence of evidence contributing to each network estimate. Sensitivity analyses will investigate effects at different dose regimens.

Ethics and dissemination

No institutional review board approval will be necessary. The results of this systematic review and meta-analysis will be presented at national and international conferences and published in peer-reviewed journals.

PROSPERO registration number

CRD42021295352.
Nurses’ perspectives on the barriers to and facilitators of the implementation of secondary prevention for people with coronary heart disease: a qualitative descriptive study
Authors: Ni Yunxia , Wen Ya , Bao Yun , Xu Ying , Chen Zhonglan , Yang Xuemei , He Juan , You Guiying
Published: September 2022

Objectives

To identify the barriers to and facilitators of secondary prevention among people with coronary heart disease from the perspectives of nurses.

Design

A qualitative descriptive design using face-to-face semistructured interviews.

Setting

This study was conducted in China from October to November 2021.

Participants

Registered nurses who had experience conducting secondary prevention for coronary heart disease were purposively recruited. Twelve nurses from 10 hospitals participated in this study. The data were analysed using content analysis based on the Theoretical Domains Framework.

Results

Based on the Theoretical Domains Framework, barriers to and facilitators of secondary prevention were identified within four key themes: nurse attributes (eg, knowledge and skills, motivation), patient characteristics (eg, age, education and economic conditions), the environmental context and resources (eg, organisational support, including financial support, clarity of responsibilities) and social influence (eg, economic development level, patient feedback).

Conclusions

This research highlights the importance of nurses’ motivation for delivering preventive care. Organisations should provide adequate support and establish a quality management system to maintain the quality of secondary prevention.
Trainee perceptions of resident duty hour restrictions: a qualitative study of online discussion forums
Authors: Dehmoobad Sharifabadi Anahita , Clarkin Chantalle , Doja Asif
Published: September 2022

Objective

Resident duty hour (RDH) restrictions in postgraduate medical education is a controversial yet important topic for study. There is limited literature on authentic trainee perceptions surrounding RDH restrictions to inform evaluation and future planning. Online forums are a widely accessible, yet underused resource, for insight into trainee perceptions. Our objective was to qualitatively assess trainee perceptions of RDH restrictions on online discussion forums.

Setting

Online discussion forums; Premed101 (Canadian forum) and Student Doctor Network (SDN) (American forum).

Participants

6630 posts from 161 discussion threads; comprising 429 posts in 14 threads from Premed101 and 6201 posts in 147 threads from SDN. Posters included medical students, residents and attending physicians.

Design

Data were analysed inductively and iteratively to create themes and subthemes. Cocoding, consensus-based decision making and an audit trail were used to ensure trustworthiness.

Results

Key findings distilled across both forums include: the relationship between hours worked and competence, the inapplicability of blanket RDH restrictions to all specialties and the inter-relationship between fatigue and patient safety. Discussions of RDH restriction compliance and perceived consequence for the reporting of violations were also featured on the American SDN forum.

Conclusions

The findings of this study reveal multiple themes pertinent to the implementation and revision of RDH restrictions. The most prominent theme was the inapplicability of blanket restrictions on duty hours theme due to the diversity of training needs across specialties and the environmental context of training programmes. Other discussions included the inter-relationship of patient safety and resident competence with duty hours. Lastly, concerns regarding the lack of transparency and psychological safety surrounding RDH violations, were discussed.
Employment status and bereavement after parental suicide: a population representative cohort study
Authors: Bélanger Sissel Marguerite , Stene-Larsen Kim , Magnus Per , Reneflot Anne , Christiansen Solveig Glestad , Hauge Lars Johan
Published: September 2022

Objectives

To examine employment status among adults bereaved by parental suicide at the time of bereavement and 2 and 5 years after the loss and to explore the importance of the gender of the adult child and the deceased parent.

Design

Population-based register study.

Setting

Norwegian population-based registries linked using unique personal identifiers.

Participants

Norwegian residents aged 25–49 years in the period 2000–2014. Participants were divided into three groups: bereaved by parental suicide, bereaved by parental death of other causes and non-bereaved population controls.

Main outcome measures

ORs for the risk of non-employment at the time of bereavement and 2 and 5 years after the loss.

Results

Those bereaved by parental suicide had a higher risk of non-employment already at the time of bereavement (OR 1.14, 95% CI 1.05 to 1.23). Stratified analyses showed that women accounted for this difference (OR 1.20, 95% CI 1.09 to 1.33), while no difference was found for men (OR 1.00, 95% CI 0.88 to 1.13). Looking at the gender of the parent, there was only a significant association of non-employment when losing a mother (OR 1.24, 95% CI 1.08 to 1.42), while not for losing a father (OR 1.09, 95% CI 0.99 to 1.20). Among those working at the time of bereavement, offspring bereaved by suicide were more likely to be non-employed at both 2 (OR 1.13, 95% CI 0.99 to 1.30) and 5 (OR 1.20, 95% CI 1.02 to 1.40) years after the loss compared with the general population.

Conclusions

Women bereaved by parental suicide and those losing a mother to suicide were found to have a weaker attachment to the labour market already before losing their parent. Those who were employed when bereaved by suicide were somewhat more likely to be non-employed 5 years after the event.
Which physical therapy intervention is most effective in reducing secondary lymphoedema associated with breast cancer? Protocol for a systematic review and network meta-analysis
Authors: Aguilera-Eguía Raúl Alberto , Seron Pamela , Gutiérrez-Arias Ruvistay , Zaror Carlos
Published: September 2022

Introduction

Lymphoedema associated with breast cancer is caused by an interruption of the lymphatic system, together with factors such as total mastectomy, axillary dissection, positive lymph nodes, radiotherapy, use of taxanes and obesity. Physiotherapy treatment consists of complex decongestive therapy, manual lymphatic drainage and exercises, among other interventions. Currently, there are several systematic review and randomised controlled trials that evaluate the efficacy of these interventions. However, at present, there are no studies that compare the effectiveness of all these physical therapy interventions. The purpose of this study is to determine which physical therapy treatment is most effective in reducing breast cancer-related lymphoedema, improving quality of life and reducing pain.

Methods and analysis

MEDLINE, PEDro, CINAHL, EMBASE, LILACS and Cochrane Central Register of Controlled Trials will be searched for reports of randomised controlled trials published from database inception to June 2022. We will only include studies that are written in English, Spanish and Portuguese. We will also search grey literature, preprint servers and clinical trial registries. The primary outcomes are reduction of secondary lymphoedema associated with breast cancer, improvements in quality of life and pain reduction. The risk of bias of individual studies will be evaluated using the Cochrane Risk of Bias 2.0 Tool. A network meta-analysis will be performed using a random-effects model. First, pairs will be directly meta-analysed and indirect comparisons will be made between the different physical therapy treatments. The GRADE system will be used to assess the overall quality of the body of evidence associated with the main results.

Ethics and dissemination

This protocol does not require approval from an ethics committee. The results will be disseminated via peer-reviewed publications.

PROSPERO registration number

CDR42022323541.
Advancing virtual primary care for people with opioid use disorder (VPC OUD): a mixed-methods study protocol
Authors: Hedden Lindsay , McCracken Rita K , Spencer Sarah , Narayan Shawna , Gooderham Ellie , Bach Paxton , Boyd Jade , Chakanyuka Christina , Hayashi Kanna , Klimas Jan , Law Michael , McGrail Kimberlyn , Nosyk Bohdan , Peterson Sandra , Sutherland Christy , Ti Lianping , Yung Seles , Cameron Fred , Fernandez Renee , Giesler Amanda , Strydom Nardia
Published: September 2022

Introduction

The emergence of COVID-19 introduced a dual public health emergency in British Columbia, which was already in the fourth year of its opioid-related overdose crisis. The public health response to COVID-19 must explicitly consider the unique needs of, and impacts on, communities experiencing marginalisation including people with opioid use disorder (PWOUD). The broad move to virtual forms of primary care, for example, may result in changes to healthcare access, delivery of opioid agonist therapies or fluctuations in co-occurring health problems that are prevalent in this population. The goal of this mixed-methods study is to characterise changes to primary care access and patient outcomes following the rapid introduction of virtual care for PWOUD.

Methods and analysis

We will use a fully integrated mixed-methods design comprised of three components: (a) qualitative interviews with family physicians and PWOUD to document experiences with delivering and accessing virtual visits, respectively; (b) quantitative analysis of linked, population-based administrative data to describe the uptake of virtual care, its impact on access to services and downstream outcomes for PWOUD; and (c) facilitated deliberative dialogues to co-create educational resources for family physicians, PWOUD and policymakers that promote equitable access to high-quality virtual primary care for this population.

Ethics and dissemination

Approval for this study has been granted by Research Ethics British Columbia. We will convene PWOUD and family physicians for deliberative dialogues to co-create educational materials and policy recommendations based on our findings. We will also disseminate findings via traditional academic outputs such as conferences and peer-reviewed publications.
NEPHwork: creating a quality improvement and research network for UK renal trainees
Authors: Crowe Kirsty , Savino Manuela , Williams Jennifer , Amaran Muhammad , Humphrey Toby , Medcalf James
Published: September 2022

NEPHwork was established in 2020 as a renal specialty trainee-driven national quality improvement and research network with the aim of coupling the benefits of trainee-led collaboration with the rich data collection infrastructure established by the UK renal registry. NEPHwork was established to support the development, coordination and delivery of audit and research projects by renal trainees on a national scale. The first collaborative project centred on the compliance with care quality standards in managing acute kidney injury. The project enabled a large amount of data to be collected over a relatively short period of time and allowed comparison between renal units involved in contributing to the data. The initiation of the NEPHwork collaboration had to overcome delays and service pressure related to the COVID-19 pandemic. Furthermore, the method of linkage analysis used in the data collection and lack of cohesion with regional information technology (IT) services prevented trainees from certain regions from contributing to the project and this is a key priority for the next NEPHwork collaboration.
Cardiogenetics: the role of genetic testing for inherited arrhythmia syndromes and sudden death
Authors: Specterman Mark J , Behr Elijah R
Published: September 2022

There have been remarkable advances in our knowledge of the underlying heritability of cardiac arrhythmias. Long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, progressive cardiac conduction disease and the short QT syndrome comprise the inherited arrhythmia syndromes (IASs). Pathogenic variants in cardiac ion channel and calcium handling protein genes lead to these conditions, usually in the absence of overt structural cardiac disease. Diagnosis is contingent on the ECG phenotype but genetic testing may help to confirm the diagnosis and provide information on the mechanism of arrhythmogenesis that may guide treatment and provide prognostic information in relation to the risk of sudden arrhythmic death. Clinical genetic testing uses ‘panels’ of genes that are the likely culprits for the IASs being investigated. An International Consortium (Clinical Genome Resource) has curated gene panels based on genetic and experimental evidence of causation of inherited conditions and that have a role in clinical genetic testing. A ‘single gene’ or monogenic basis for IASs exists but in future, missing heritability and incomplete penetrance will be uncovered by association of common variants through genome-wide association studies. Novel rare variants will also be detected through whole-genome sequencing. The formulation of polygenic risk scores will likely help to predict phenotypic expression and response to treatments/risk stratification and move genetic testing very much to the fore of the diagnostic process.
Effects of the Labour Inspectorate Authority’s regulatory tools on psychosocial and biomechanical work factors in Norwegian home care services: a cluster randomised controlled trial
Authors: Finnanger Garshol Bjørnar , Knardahl Stein , Emberland Jan Shahid , Skare Øivind , Johannessen Håkon A
Published: September 2022

Objectives

This study aimed to determine the effects of the Labour Inspectorate Authority’s (LIA’s) regulatory tools on psychosocial and biomechanical work factors in the Norwegian municipal home care services.

Methods

A cluster-randomised controlled trial conducted in the home care services with employee questionnaire data on work factors at baseline, and 6 and 12 months after the interventions. In total, 96 eligible municipalities were randomly assigned to either the control group or one of two interventions: (1) labour inspection visits, based on the LIA’s standard inspections; and (2) guidance-through-workshops, where the participating services highlighted issues and trained labour inspectors provided guidance based on existing labour laws and regulations.

Results

No favourable intervention effect was observed for the inspection intervention. No effects were observed for most of the variables in the guidance intervention, although an effect was observed for the following psychosocial factors: decision control, control over work intensity and empowering leadership. However, after adjusting for multiple testing, none of the observed effects were statistically significant.

Conclusion

Labour inspections did not affect psychosocial and biomechanical work factors in the home care services. A favourable effect of the guidance intervention on psychosocial work factors was observed. However, this was not evident after adjusting for multiple testing. Further research is needed to elaborate on how labour inspections and other regulatory tools can impact psychosocial and biomechanical work factors.

Trial registration number

NCT03855163.
Impact of the European Union’s menthol cigarette ban on smoking cessation outcomes: longitudinal findings from the 2020–2021 ITC Netherlands Surveys
Authors: Kyriakos Christina N , Driezen Pete , Fong Geoffrey , Chung-Hall Janet , Hyland Andrew , Geboers Cloé , Quah Anne C K , Willemsen Marc C , Filippidis Filippos T
Published: September 2022

Introduction

To reduce the appeal of tobacco, the European Union (EU) banned menthol as a characterising flavour in cigarettes in May 2020. This pre/post-study evaluated the impact of the menthol ban on smoking cessation outcomes among a representative cohort of Dutch smokers.

Methods

Adult (18+ years) smokers were recruited at wave 1 (pre-ban) of the International Tobacco Control Netherlands Surveys (February–March 2020) and followed post-ban at wave 2 (September–November 2020) and wave 3 (June–July 2021) (N=1326 participated in all three waves). Weighted bivariate, logistic regression and generalised estimating equation model analyses were conducted.

Results

Usual menthol use decreased from pre-ban (7.8%) to post-ban (4.0% at wave 2 and 4.4% at wave 3) (p<0.001). Pre-ban menthol smokers had greater odds of making a post-ban quit attempt than non-menthol smokers (66.9% vs 49.6%, adjusted OR (aOR)=1.89, 95% CI: 1.13 to 3.16). Compared with pre-ban non-menthol smokers, a higher proportion of menthol smokers quit by wave 2 (17.8% vs 10.2%, p=0.025) and by wave 3 (26.1% vs 14.1%, p=0.002), although this was not significant after adjusting for other factors. Female pre-ban menthol smokers had greater odds of quitting by wave 3 than female non-menthol smokers (aOR=2.23, 95% CI: 1.10 to 4.51). Most pre-ban menthol smokers (n=99) switched to non-menthol cigarettes (40.0%) or reported that they continued to smoke menthol cigarettes (33.0%) at wave 3.

Conclusions

The EU menthol ban was effective in reducing menthol use and in increasing quit attempts and quitting among pre-ban menthol smokers. Impact could be maximised by closing gaps that allow post-ban menthol cigarette use.
Puzzling time properties of proportional electroluminescence in two-phase argon detectors for dark matter searches
Authors: Buzulutskov A. , Frolov E. , Borisova E. , Nosov V. , Oleynikov V. , Sokolov A.
Published: September 2022

Proportional electroluminescence (EL) in noble gases is a physical process routinely used in two-phase (liquid–gas) detectors for low-energy astroparticle-physics experiments. In this work, the time properties of visible-light EL in two-phase argon detectors have been systematically studied for the first time. In particular, two unusual slow components in the EL signal, with their contributions and time constants increasing with electric field, were observed. This puzzling property is not expected in any of the known mechanisms of photon and electron emission in two-phase media. Time constants of these components is about 4–5 $$\upmu $$
μ
s and 50 $$\upmu $$
μ
s. In addition, a specific threshold behavior of the slow components was revealed: they emerged at a threshold in reduced electric field of 4.8 ± 0.2 Td regardless of the gas phase density, which is about 1 Td above the onset of standard (excimer) EL. There is a conspicuous similarity between this threshold and reduced field threshold of EL in NIR occurring via higher atomic excited states Ar$$^{*}(3p^{5}4p)$$

∗

(
3

p
5

4
p
)

. An unexpected temperature dependence of slow components was also observed: their contribution decreased with temperature, practically disappearing at room temperature. We show that the puzzling properties of slow components can be explained in the framework of hypothesis that these are produced in the charge signal itself due to trapping of drifting electrons on metastable negative argon ions.
Hidden conformal symmetries in Kerr–de Sitter spacetime revisited
Authors: Siahaan Haryanto M.
Published: September 2022

We study the holographic picture for the Kerr–de Sitter spacetime with multiple horizons. Motivated by the studies of hidden conformal symmetry that associates to the black hole horizon, we show that such symmetry can also exist for the cosmological horizon that can lead us to the holographic calculation for the cosmological horizon entropy. To support the holography, we provide the scalar scattering calculation in the corresponding near region of each horizon by using the dual CFT formula. As one would expect, the cosmological horizon entropy and the associated scalar scattering can be understood by using a two dimensional conformal field theory.
Automatic Reuse, Adaption, and Execution of Simulation Experiments via Provenance Patterns
Authors: Wilsdorf Pia , Wolpers Anja , Hilton Jason , Haack Fiete , Uhrmacher Adelinde
Published: September 2022

Simulation experiments are typically conducted repeatedly during the model development process, for example, to revalidate if a behavioral property still holds after several model changes. Approaches for automatically reusing and generating simulation experiments can support modelers in conducting simulation studies in a more systematic and effective manner. They rely on explicit experiment specifications and, so far, on user interaction for initiating the reuse. Thereby, they are constrained to support the reuse of simulation experiments in a specific setting. Our approach now goes one step further by automatically identifying and adapting the experiments to be reused for a variety of scenarios. To achieve this, we exploit provenance graphs of simulation studies, which provide valuable information about the previous modeling and experimenting activities, and contain meta-information about the different entities that were used or produced during the simulation study. We define provenance patterns and associate them with a semantics, which allows us to interpret the different activities and construct transformation rules for provenance graphs. Our approach is implemented in a Reuse and Adapt framework for Simulation Experiments (RASE), which can interface with various modeling and simulation tools. In the case studies, we demonstrate the utility of our framework for (1) the repeated sensitivity analysis of an agent-based model of migration routes and (2) the cross-validation of two models of a cell signaling pathway.
Research on Multi-physics Field Coupling Dynamic Process in Forward Flow Electrochemical Trepanning Blades
Authors: Tao Jin , Xu Jinkai , Ren Wanfei , Xu Zhenming , Yu Huadong
Published: September 2022

In this work, a multi-physics field coupling model based on electric field, gas-liquid two-phase flow field and temperature field of the forward flow electrochemical trepanning (FFECT) blades was established, and the distribution law of hydrogen bubble volume fraction, electrolyte temperature and electrolyte conductivity in machining gap was obtained. Based on the simulation results, the time-varying process of electrolyte flow velocity distribution was divided into three stages according to the change in machining gap corresponding to different blade machining heights H, and the effects of the machining voltage U and the cathode feed rate v on the side gap Δ
s
and the end gap Δ
e
were investigated. The simulation analysis and experimental results show that both side gap and end gap increase as machining voltage increases while decrease with the increase in cathode feed rate. The model predictions are in good agreement with the experimental results, and the maximum errors of side gap and end gap are 10.6% and 17.7% respectively. In addition, the effects of machining voltage and cathode feed rate on the surface quality were studied experimentally. Results reveal that surface roughness can be reduced by appropriately decreasing the machining voltage and increasing the cathode feed rate.
Lithium Ionic Conductive Mechanism in PEO Polymer Electrolytes Enhanced by Nano/Micron Size LLZO Fillers
Authors: Chen Fei , Lu Xinqi , Cao Shiyu , Zhang Yiluo , Li Jun
Published: September 2022

Solid polymer electrolytes (SPEs) incorporating inorganic ceramic fillers are key solutions of all solid-state lithium battery technology applications. At present, the conductive mechanism of LLZO-PEO electrolyte is still controversial. Herein, the effect of nano and micron LLZO on the conductive mechanism of PEO matrix with different molecular weight is studied. The low molecular weight PEO electrolyte (LSPEs) containing nano LLZO exhibit higher conductivities than those with the micron ones, which is primarily caused by the percolation effect resulting from the difference in specific surface area. However, for high molecular weight PEO electrolytes (HSPEs), the addition of nano LLZO ceramic fillers can mainly lead to reduce the crystallinity of HSPEs to enhance the motion of polymer segment. Thus, compared with HSPEs alone, the nano LLZO-HSPEs show conductivities one order of magnitude larger. Besides, the discharge capacity of nano LLZO-HSPEs based LiFePO4/Li batteries at 1 C is around 131 mAh g−1 at 60 °C, as well as discharge specific capacity holds 99.2% after 200 cycles. Notably, nano LLZO ceramic fillers will enhance cyclic performance of LiFePO4/Li batteries at 0.2 C and 40 °C, which still maintain 126.7 mAh g−1 after 50 cycles.
Determining the Critical Pit Stability Product of Stainless Steels
Authors: Wang Ke , Salasi Mobin , Iannuzzi Mariano
Published: September 2022

In this work, a galvanostatic method based on the one-dimensional pit electrode technique was developed to identify the critical pit stability product of 316 L stainless steel (SS). The critical pit stability product of 316 L SS in 0.6 M NaCl at 25 °C was between 0.8 and 0.9 A m−1, which was confirmed by mass transport modelling and potentiodynamic polarization results in pit-like solutions. The critical concentration of metal cations at the pit base was between 70 and 82% of the saturation concentration. The implications of these findings are discussed in detail.
Network Public Opinion Propagation Control Model of Major Emergencies Based on Heat Conduction Theory
Authors: Wei Yong
Published: September 2022

In physics, the process of heat conduction of objects is similar to the process of network public opinion propagation of major emergencies. Based on the theory of heat transfer, this paper analogizes the process of network public opinion information propagation and object heat conduction and analogizes the exchange of network public opinion information between individuals in social networks to the course of object heat transfer. Based on the accumulation of individual energy in social network, the propagation model of network public opinion is established, and the propagation control model of network public opinion in major emergencies is established based on the heat conduction theory. The influence of individual interest, propensity to spread, transmission coefficient of network public opinion information, and the breadth of dissemination on the dissemination of network public opinion in major emergencies are analyzed, respectively. This study provides some inspiration for the disposal and governance of network public opinion, propagation of major emergencies.
Experimental Study on Grouting Seepage Characteristics of Single-Fractured Rock Masses with Different Inclination Angles under Three-Dimensional Stress
Authors: Zhu Hexuan , Han Lijun
Published: September 2022

In underground engineering, the fracture dip angle and three-dimensional stress have great influence on the permeability and mechanical properties of fractured rock mass. Firstly, single-fracture samples with similar three-dimensional fractal dimensions and different dip angles were selected by using CT scanning technology. Then, the grouting material seepage tests under different dip angles and different three-dimensional stresses were carried out by self-developed single-fracture stress-seepage coupling true triaxial test system. The experimental data of stress-strain curve, grouting pressure, and grouting material flow rate of single-fracture specimen under different fracture dip angles and three-dimensional stress were obtained. The results show that the three-dimensional fractal dimension can be used as an index to measure the influence of fracture factors on grouting seepage test. The third principal stress

σ

3

had a greater influence on the fracture width than the first principal stress

σ

1

. The larger the fracture inclination, the lower the strength of the single-fracture specimen. As the third principal stress

σ

3

increases, the grouting pressure increased while the grouting flow decreased. With the increase of the fracture inclination angle, the influence of

σ

1

on the hydraulic conductivity became larger, while the influence of

σ

3

on the hydraulic conductivity became smaller. Moreover, the expression of hydraulic conductivity of single-fracture specimen with different dip angles under three-dimensional stress was obtained by nonlinear fitting of hydraulic conductivity data.
Analysis of the Effect of the Integration Development of Sports Economy and Health Industry in the Context of Public Health Based on Big Data Analysis Technology
Authors: Chen Liquan
Published: September 2022

In order to guide and meet people’s health needs, various resources are flowing to the health sector, and the regional health economy is bound to develop rapidly, which increases the possibility of integrating and developing the sports economy and health industry in the context of the public health sector. As the health of the population improves, life expectancy increases, science and technology develops, and lifestyles change, the health economy sector is becoming increasingly active and both sport and healthcare will contribute to the development of the regional health economy. Big data, as a new management mindset and technical tool, brings new opportunities and challenges to the integrated development of sports economy and health industry. Based on the basic characteristics of big data, this paper provides a strategy for the development of the sports and health integration industry by using research methods such as grey correlation analysis, expert interviews, and agglomeration measures, starting from the problems faced by the integration development of China’s sports industry to guarantee the construction of conditions. The experiment is analysed through the big data presentation of the health industry and the big data modelling ideas of grey correlation analysis, which provides new ideas to expand the application research of grey correlation analysis in the field of integration development.
Diabetes Is a Risk Factor for the Prognosis of Patients with Bladder Cancer: A Meta-Analysis
Authors: Dong Lv , Ying Xiang , Tao Song , Guang-Peng Zhou , Tai-Ming Shen
Published: September 2022

Objective. To systematically evaluate the impact of diabetes on the prognosis of bladder cancer patients after radical cystectomy (RC). Methods. PubMed, Embase, and Cochrane Library databases were selected from inception to October 2021. The studies on the effects of diabetes on bladder cancer patients after RC were included for analysis. The inclusion and exclusion criteria were independently selected for literature screening, the quality of the included studies was evaluated, and data were extracted. Results. A total of 5 cohort studies were included, with a total of 2 661 subjects, including 391 cases in the diabetic group, non-diabetes. Meta-analysis results show that diabetes increases the overall risk of death in patients after RC (HR = 1.36, 95% CI: 1.30 ∼ 1.43,

P
<
0.001

) and the risk of tumor-specific death (HR = 1.59, 95% CI: 1.29 ∼ 1.95,

P
<
0.001

). Sensitivity analysis shows that the stability of this study is well. Conclusion. Diabetes was an independent risk factor in terms of overall and cancer-specific survival in patients who underwent RC.
Carbon Emissions, Ecological Efficiency, and the Economic Development Stage: Evidence from the Yellow River Basin
Authors: Han Yan , Wang Xinpu , Zhe Caihong
Published: September 2022

This paper has explored the relationship between CO2 emissions, eco-efficiency, and economic growth, which has important theoretical and practical significance for realizing high-quality development of the Yellow River Basin (YRB). Based on the data of 99 prefecture-level cities in the YRB from 2003 to 2017, this paper analyses the temporal and spatial variation and agglomeration characteristics of CO2 emissions and eco-efficiency in the YRB. The spatial Durbin model (SDM) with fixed effects is used to test the relationship between CO2 emissions, eco-efficiency, and economic growth in the YRB by using new structural economics theory and the EKC hypothesis. The results show that (1) the YRB is in a stage of extensive economic development with the coexistence of high CO2 emissions and low eco-efficiency and shows a trend of transformation and upgrading to a stage of high-quality economic development; (2) CO2 emissions and eco-efficiency are spatially heterogeneous; CO2 emissions and eco-efficiency in the upper reaches are low, and the middle maintains relatively high eco-efficiency and high CO2 emissions while the lower reaches have both high CO2 emissions and low eco-efficiency; (3) the relationship between CO2 emissions and economic growth is N-shaped, and there is an inflection point of accelerated increase (per capita GDP is 45,558 yuan). The YRB has crossed this inflection point, and CO2 emissions are accelerating with economic development at this stage. The relationship between eco-efficiency and economic growth is U-shaped, with the inflection point of per capita GDP at 46,483 yuan. The YRB has just crossed the point, and eco-efficiency will subsequently steadily rise with economic development.
Palbociclib Enhances Migration and Invasion of Cancer Cells via Senescence-Associated Secretory Phenotype-Related CCL5 in Non-Small-Cell Lung Cancer
Authors: Kong Pengzhou , Yang Xin , Zhang Yingying , Dong Huiling , Liu Xiangchen , Xu Xiaoqin , Zhang Xinri , Shi Yiwei , Hou Mingxia , Song Bin
Published: September 2022

Palbociclib is the first CDK4/6 inhibitor approved by FDA and has been studied in many types of cancer. However, some studies showed that it could induce epithelial-mesenchymal transition (EMT) of cancer cells. To test the effect of palbociclib on non-small-cell lung cancer (NSCLC) cells, we treated NSCLC cells with different concentrations of palbociclib and detected its effects via MTT, migration and invasion assays, and apoptosis test. Further RNA sequencing was performed in the cells treated with 2 μM palbociclib or control. And Gene Ontology, Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Set Enrichment Analysis (GSEA), and protein-protein interaction network (PPI) were analyzed to explore the mechanism of palbociclib. The results showed that palbociclib significantly inhibited the growth of NSCLC cells and promoted apoptosis of cells, however, enhanced the migration and invasion abilities of cancer cells. RNA sequencing showed that cell cycle, inflammation-/immunity-related signaling, cytokine-cytokine receptor interaction, and cell senescence pathways were involved in the process, and CCL5 was one of the significantly differential genes affected by palbociclib. Further experiments showed that blocking CCL5-related pathways could reverse the malignant phenotype induced by palbociclib. Our results revealed that palbociclib-induced invasion and migration might be due to senescence-associated secretory phenotype (SASP) rather than EMT and suggested that SASP could act as a potential target to potentiate the antitumor effects of palbociclib in cancer treatment.
Analysis of the Combination of the Regional Natural Environment and Local Characteristics of the Tourism Industry under the Perspective of Synergistic Development
Authors: Xiao Hongyi
Published: September 2022

Ecological environmental protection and tourism development are complex systems that are inextricably linked, mutually influencing, and interdependent, forming an organic whole. The natural environment and its various natural factors constitute an ecosystem, which both is a prerequisite for regional tourism development and has a certain impact on the regional ecosystem. The development of tourism must take the protection of the natural environment as the premise, the protection of ecological environment must be throughout the whole process of tourism development, and the principles and methods of system science must be used to solve this problem. Tourism is an important strategic support for the development of China’s national economy. However, with the rapid increase in the number of tourists, tourist attractions are also facing unprecedented pressure. Tourism and its related industries are a complex and open system that consists of economic, social, and ecological environment; policy; technology; and other factors. By analyzing the interrelationship of each element in the tourism sustainable development system, we can provide a scientific basis for sustainable tourism development.
Willingness to Pay for Safe Chicken Meat in Bangladesh: A Contingent Valuation Approach
Authors: Saha Sourav Mohan , Prodhan Md. Masudul Haque , Rahman Md. Shahidur , Haque A.B.M. Mahfuzul , Iffah Khandkar , Khan Md. Akhtaruzzaman
Published: September 2022

The poultry meat industry is primarily dominated by broilers, and conventional broiler meat is claimed to be malicious to human health and environment since it is produced using hazardous feeds and other dietary supplements. This study aimed to evaluate consumers’ willingness to pay (WTP) for safe broiler chicken meat following a contingent valuation model (CVM). Also, consumers’ consumption and different types of perceptions on safe broiler meat were assessed from the data collected among 300 consumers in Bangladesh. Consumers’ health and environmental perception of safe broiler meat are found to be high, indicating that they are more concerned about these attributes in the case of consuming broiler meat. The results reveal that conventional broiler meat losses its appeal to consumers after a certain income level and is mainly consumed by lower- and middle-income groups. This study divulges a unanimous demand for safe broiler meat among the consumers who intend to consume about 36% higher than their present consumption level if the availability was ensured in their local market. The average WTP premium for safe broiler meat is estimated to be about BDT 39.87 per kg. The consumers’ WTP is positively influenced by their education, income level, the current consumption of broiler chicken meat, health perception, and taste and nutrition perception. This study recommends meat producers, entrepreneurs, and farmers adjust their production and marketing plans by incorporating suitable quality control procedures to meet the unfilled consumer demand for safer broiler meat. Besides, slow-growing safer broiler chicken needs to be introduced to improve meat’s taste and nutritional aspects.
Accuracy and Utility of Preoperative Ultrasound-Guided Axillary Lymph Node Biopsy for Invasive Breast Cancer: A Systematic Review and Meta-Analysis
Authors: Huang Yihong , Zheng Shuo , Lin Yu
Published: September 2022

Background. With the acceleration of the pace of life and work, the incidence rate of invasive breast cancer is getting higher and higher, and early diagnosis is very important. This study screened and analyzed the published literature on ultrasound-guided biopsy of invasive breast cancer and obtained the accuracy and practicality of preoperative biopsy. Method. The four databases were screened for the literature. There was no requirement for the start date of retrieval, and the deadline was July 2, 2022. Two researchers screened the literature, respectively, and included the literature on preoperative ultrasound-guided biopsy and intraoperative and postoperative pathological diagnosis of invasive breast cancer. The diagnostic data included in the literature were extracted and meta-analyzed with RevMan 5.4 software, and the bias risk map, forest map, and summary receiver operating characteristic curves (SROC) were drawn. Results. The included 19 studies involved about 18668 patients with invasive breast cancer. The degree of bias of the included literature is low. The distribution range of true positive, false positive, true negative, and false negative in the forest map is large, which may be related to the large difference in the number of patients in each study. Most studies in the SROC curve are at the upper left, indicating that the accuracy of ultrasound-guided axillary biopsy is very high. Conclusion. For invasive breast cancer, preoperative ultrasound-guided biopsy can accurately predict staging and grading of breast cancer, which has important reference value for surgery and follow-up treatment.
Modeling and Dynamics of the Fractional Order SARS‐CoV‐2 Epidemiological Model
Authors: Khan Tahir , Ullah Roman , Yousef Ali , Zaman Gul , Al-Mdallal Qasem M. , Alraey Yasser
Published: September 2022

We propose a theoretical study to investigate the spread of the SARS‐CoV‐2 virus, reported in Wuhan, China. We develop a mathematical model based on the characteristic of the disease and then use fractional calculus to fractionalize it. We use the Caputo-Fabrizio operator for this purpose. We prove that the considered model has positive and bounded solutions. We calculate the threshold quantity of the proposed model and discuss its sensitivity analysis to find the role of every epidemic parameter and the relative impact on disease transmission. The threshold quantity (reproductive number) is used to discuss the steady states of the proposed model and to find that the proposed epidemic model is stable asymptotically under some constraints. Both the global and local properties of the proposed model will be performed with the help of the mean value theorem, Barbalat’s lemma, and linearization. To support our analytical findings, we draw some numerical simulations to verify with graphical representations.
Network Pharmacology-Based Exploration of the Mechanism of Action of Shugan Hewei Recipe in the Treatment of Gastroesophageal Reflux Disease with Anxiety and Depression
Authors: Xu Tingting , Liu Chunfang , Zhang Xiulian , Geng Lin , Wang Hongwei , Li Li , Zhu Shengliang
Published: September 2022

The Shugan Hewei recipe (SHR) is a well-recognized traditional Chinese medicine (TCM) prescription that has been shown to significantly improve chest pain, acid regurgitation, and the mood of GERD. Nonetheless, the underlying mechanisms remain unclear. In this study, the active compounds and targets of SHR were predicted using network pharmacology. Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were utilized to explore the therapeutic mechanism of SHR. Combined with the drug target obtained from network pharmacology, the therapeutic effect and mechanism of SHR were observed. SHR’s main active compounds included quercetin, kaempferol, and luteolin. The core targets of SHR and GERD were TGF-β1, IL-1β, IL-4, CXCL10, MAPK1, MAPK3, CXCL8, IL-10, IL-2, and FOS, involving virus infection, inflammatory response, and body immunity. The core targets of SHR during the treatment of mental disorders were GABRA1, GABRA2, GABRA3, GABRA5, and GABRA6, involving synaptic transmission and transmembrane movement. Animal experiments revealed that SHR could repair the lower esophageal mucosa, mediate inflammatory factors, and GABA receptors and improve the behavior of rats. Overall, our results substantiate that SHR has huge prospects for widespread application in treating GERD subjects with anxiety and depression.