bluuebunny/crossref_metadata_2025 huggingface dataset:
Genome-wide characterization and expression analysis of geranyl geranyl diphosphate synthase genes of cotton (Gossypium spp.) in plant development and abiotic stresses
Authors: Ali Faiza , Qanmber Ghulam , Wei Zhenzhen , Yu Daoqian , Li Yonghui , Gan Lei , Li Fuguang , Wang Zhi
Published: April 2020

Background: GGPP (geranyl geranyl diphosphate) is produced in the isoprenoid pathway and mediates the function of various plant metabolites, which is synthesized by GGPPS (GGPP synthases) in plants. GGPPS characterization has not been performed in any plant species except Arabidiosis thaliana. Here, we performed a complete computational and bioinformatics analysis of GGPPS and detected their transcription expression pattern in Gossypium hirsutum for the first time in order to explore their evolutionary relationship and potential functions. We unravel evolutionary relationship, conserved sequence logos, gene duplication and potential involvement in plant development and abiotic stresses tolerance of GGPPS genes in G. hirsutum.Results: A total of 134 GGPPS genes from 17 plant species were identified. Evolutionary analysis divided GGPPS genes into five groups and indicated their divergence from a common ancestor. Further, GGPPS family genes were conserved during evolution and underwent segmental duplication. 25 GhGGPPS genes identified showed diverse expression pattern particularly in ovule and fiber development indicating their vital and divers roles in the fiber development. Additionally, GhGGPPS genes exhibited wide range of responses when subjected to abiotic (heat, cold, NaCl and PEG) and hormonal (BL, GA, IAA, SA and MeJA) stresses. Conclusions: Collectively, GGPPS genes are evolutionary conserved, may are involved in different development stages and stress signaling pathways, some potential key genes (e.g. GhGGPP4, GhGGPP9, GhGGPP15) were suggested and provide valuable source for cotton breeding in fiber quality and resistant to various stresses.
Detection of subgenome bias using an anchored syntenic approach in Eleusine coracana (finger millet)
Authors: Hall Nathan Daniel , Patel Jinesh D , McElroy Joseph Scott , Goertzen Leslie Richard
Published: April 2020

Background: Finger millet (Eleusine coracana 2n=4x=36 ) is a hardy, nutraceutical, climate change tolerant, orphan crop that is consumed throughout eastern Africa and India. Its genome has been sequenced multiple times, but A and B subgenomes could not be separated because no published genome for E. indica existed. The classification of A and B subgenomes is important for understanding the evolution of this crop and provide a means to improve current and future breeding programs.Results: We produced subgenome calls for 704 syntenic blocks and inferred A or B subgenomic identity for 59,377 genes 81% of the annotated genes. Phylogenetic analysis of a super matrix containing 455 genes shows high support for A and B divergence within the Eleusine genus. Synonymous substitution rates between A and B genes supports A and B calls. The repetitive content on highly supported B contigs is higher than that on similar A contigs. Analysis of syntenic singletons showed evidence of biased fractionation showed a pattern of A genome dominance, with 61% A , 37% B and 1% unassigned, and was further supported by the pattern of loss observed among cyto-nuclear interacting genes. Examination of expression within the ciradian rhythm pathway suggests A subgenomic preference.Co﻿nclusion: The evidence of individual gene calls within each syntenic block, provides a powerful tool for inference for subgenome classification. Our results show the utility of a draft genome in resolving A and B subgenomes calls, primarily it allows for the proper polarization of A and B syntenic blocks. There have been multiple calls for the use of phylogenetic inference in subgenome classification, our use of synteny is a practical application in a system that has only one parental genome available.
Development, validation and implementation of a program to detect malnutrition with NRS-2002 screening tool in patients of the oncology and hematology service
Authors: Pérez Marta , Soriano José M , Merino-Torres J Francisco
Published: April 2020

Background: Hospital malnutrition is an increasingly prevalent situation, which involves both an increase in health costs, a decrease in the life quality of those who suffer from it, and greater morbimortality. Nutritional screening is essential to detect malnutrition early and avoid these complications.Methods: NRS-2002 was performed on all patients admitted to the oncohaematology service, followed by the complete nutritional assessment (VN) to check its validity, which is repeated weekly to determine the degree of malnutrition during the hospital stay. Data were summarized using mean (standard deviation) and median (1st, 3rd quartile) for numerical variables, and absolute frequency (relative) for qualitative variables. To measure agreement between the two diagnoses, Cohen's Kappa was calculated for each visit. The level of association between the variables was measured using the Goodman and Kruskal measure.Results: 573 patients were admitted to the oncohaematology service, of which: 34.4% malnutrition, 44.7% risk of malnutrition and 20.9% good nutritional condition, on admission to hospital according to the NRS-2002. In patients admitted for more than a week, NRS-2002 was performed weekly and found that, upon discharge, they suffered: 34.4% malnutrition, 50.8% risk of malnutrition and 14.76% good nutritional status; also 12.3% worsen their nutritional status, 68.9% maintain it and only 18.9% improve it. 78.8% of patients with longer admissions require a VN.Conclusions: Our results suggest that the NRS-2002 is a simple and effective method for early malnutrition detection. It's important a nutritional monitoring during the hospitalization period, because the patients are susceptible to worsening of their nutritional status.
Plasma transfusion promoted reprogramming CD4+ T lymphocytes immune response in severe sepsis mice model through modulating the exosome protein Galectin 9
Authors: Zhang Lei , Zhang Jian-Ping , Liu Yang , Wang Huan , Cheng Yong , Wang Jin-Huo , Zhang Wen-Jie , Li Zhen-Zhou , Guo Jian-rong
Published: April 2020

Sepsis is a life-threatening disease resulting in excessive stimulation of the host’s immune cells. In the study, the purpose is to investigate the roles of fresh frozen plasma (FFP) transfusion in shaping the CD4+ T lymphocytes immune response through modulating the secreted exosome protein Galectin 9 in mice with severe sepsis. We firstly identified the protein Galectin 9 highly accumulated in the blood plasma of severe sepsis mice with western blot, then with transmission electron microscopy (TEM) and protein analysis, we found protein Galectin 9 was a secreted exosome protein in sepsis mice. Thereafter, we treated the severe sepsis mice with antibiotic-Cefuroxime Axetil, meanwhile, one group mice received FFP transfusion, the other one group mice received normal saline. Surprisingly, the FFP transfusion reduced the secretion of exosome protein Galectin 9 and there was crosstalking between the exosome protein Galectin 9 and CD4+ T lymphocytes in mice with severe sepsis. Results showed that the proliferation of Th1, Th17 were promoted and obiviously inhibited Treg cells maintenance in the sepsis mice receiving FFP transfusion. Correspondingly, this immune reprogrammed activity shaped the inflammatory cytokines secretion with increase of IL-1β, IL-6 and IFN-γ, whilst, decrease of IL-10. Taken together, it was suggested that FFP transfusion promoted reprogramming CD4+ T lymphocytes immune response through inhibiting the secretion of exosome protein Galectin 9 in mice with severe sepsis to relieve immunosuppression.
Cardiac differentiation of bone marrow resident c-kit+ stem cells by L-carnitine increases through secretion of VEGF, IL6, IGF-1 and TGF-β
Authors: Farahzadi Raheleh , Fathi Ezzatollah , Vietor Ilja , Javanmardi Sara
Published: April 2020

Background: The idea of regenerating lost myocardium via cell therapies remains highly considerable. Also, C-kit+ stem/progenitor cells are represented to be suitable candidates for cardiac regeneration compared to other stem cells. A multitude of cytokines from these cells are known to give such multifunctional properties; however, associated mechanisms of these factors must still be absolutely understood. On the other hand, loss of cell survival and functionality, is one of the main problems in regenerative medicine. The aim of the present study was to investigate the in vitro effect of L-carnitine (LC) on cardiac differentiation of c-kit+ cells via cytokines secretion assay. Methods: For this purpose, bone marrow resident-c-kit+ cells were enriched by MACS method, and were differentiated to cardiac cells in the absence (-LC) and presence of LC (+LC). Also, Characterization of enriched c-kit+ cells was performed using flow cytometry and immunocytochemistry. At the end of the treatment period, the cells were subjected to real-time PCR along with western blotting assay for gene and protein assessment, respectively. Then, culture medium was collected from both control (-LC) and experimental groups (+LC) for cytokine array. Results: It was found that 0.2 mM LC induces cardiac differentiation of c-kit+ cells via increasing the cardiac markers expression of Ang-1, Ang-2, C-TnI, VEGF, vWF, and SMA. Also, the significant presence of IL-6, IGF-1, TGF-β, and VEGF were obvious in the cultured media. Conclusion: It can be concluded that in vitro effects of LC on cardiac differentiation of c-kit+ cells could be due to the secreted cytokines IL-6, IGF-1, TGF-β, and VEGF.
Spatial patterns of microbial nitrogen genes along precipitation gradient in different temperate grasslands of Inner Mongolia, China
Authors: Zhou Shutong , Xue Kai , Zhang Biao , Tang Li , Pang Zhe , Wang Fang , Che Rongxiao , Ran Qinwei , Xia Anquan , Wang Kui , Li Linfeng , Dong Junfu , Du Jianqing , Hu Ronghai , Hao Yanbin , Cui Xiaoyong , Wang Yanfen
Published: April 2020

Background: Despite the importance of microorganisms in soil nitrogen (N) cycling, studies on spatial patterns of microbial N genes in the temperate grassland are still lacking, whose productivity is limited by N. Here, we investigated microbial N genes from 60 temperate grassland sites across 1 161 km in Inner Mongolia, China. Results: All N gene abundances tended to decrease from northeast to southwest, consistent with precipitation change but contrary to temperature trend. Most N gene abundances increased with rising precipitation when < 321 or 403 mm, but remained stable after breaking points, indicating non-linear saturation curves dominated response patterns. Moreover, decay relationships were discovered for N gene community over geographic distance, whose effect was direct in temperate desert steppe but indirect via environmental heterogeneity in temperate meadow and typical steppe. Representativeness of geographic distance on historical-contingency was dominant only in temperate meadow (81.2%). N gene community similarity decay was mainly attributed to plant community (76.98%), with wider range, in typical steppe; while contemporary-disturbance was the attributor more important in temperate meadow (29.41%). Conclusions: Overall, we discovered non-linear patterns of N genes along precipitation gradient, and quantified attributions of geographic distance, plant community, historical-contingency and contemporary-disturbance to N gene community similarity decay, clearly ecosystem-dependent.
Triggering outer membrane leakiness of a novel E. coli strain for recombinant protein production
Authors: Kastenhofer Jens , Rettenbacher Lukas , Feuchtenhofer Lukas , Mairhofer Jürgen , Spadiut Oliver
Published: April 2020

BackgroundRecombinant proteins in Escherichia coli are expressed inside the cell. With the growing interest in continuous cultivation, secretion of product to the medium is not only a benefit, but a necessity in future bioprocessing. In this study, we present a novel E. coli production host for growth decoupled recombinant protein production that can leak up to 90% of recombinant protein to the extracellular space. We investigated the effects of the process parameters temperature and specific glucose uptake rate on physiology, productivity, lysis and leakiness. Two model proteins were used, Protein A and a VHH single-domain antibody, and performance was compared to the industrial standard strain BL21(DE3).ResultsWe show that inducible growth repression in the novel E. coli strain enGenes-X-press, the effect of the metabolic burden on host physiology can be greatly reduced compared to BL21(DE3). Furthermore, in both strains, increasing temperature and specific substrate enhanced productivity and leakiness. Using the enGenes-X-press strain, extracellular Protein A and VHH titer reached up to 349 mg/g and 19.6 mg/g, respectively, comprising between 80 and 90% of total soluble product, while keeping cell lysis to a minimum. BL21(DE3) leaked 198 mg/g and 3.9 mg/g of Protein A and VHH to the medium, accounting for only 56% and 34% of total soluble product, respectively.ConclusionsWe confined the parameter space in which outer membrane leakiness can be controlled, while maintaining cell viability. Moreover, our findings demonstrate that the enGenes-X-press strain constitutes a superior host for extracellular production of recombinant protein.
Evaluation of the Effect of Cumulative Cisplatin Dose in Locoregionally Advanced Nasopharyngeal Carcinoma Patients Receiving Intensity-Modulated Radiotherapy
Authors: Lin Sheng-Chiao , Lin Yu-Hsuan , Lin Yaoh-Shiang , Kang Bor-Hwang , Chang Kuo-Ping , Chang Ting-Shou
Published: April 2020

Background: In nasopharyngeal carcinoma (NPC), the cut-off value of cumulative cisplatin dose (CCD) associated with survival benefits remains controversial. This study aimed to determine a CCD cut-off value for favorable survival outcomes and to identify specific patient groups benefitting from higher CCDs. Methods: We retrospectively reviewed the records of 161 patients (male-to-female ratio of 2.6:1.0) with NPC receiving concurrent chemoradiotherapy ± adjuvant chemotherapy (AC) from February 2006 through September 2015 at our referral center. The CCD was calculated for each patient, and 3-year locoregional-free survival (LRFS), distant-metastasis free survival (DMFS), disease-specific survival (DSS), and overall survival (OS) were analyzed using a multivariable Cox regression model. Results: Stage N3 patients and stage IV patients had lower DMFS, DSS, and OS. A CCD ≥ 200 mg/m 2 or AC was not associated with survival benefits. After adjusting for other factors, N3 status remained robustly correlated with DMFS ( p < 0.001) and DSS ( p = 0.001). In subgroup analyses, stage N3 patients treated with CCD ≥ 200 mg/m 2 exhibited evident trends toward higher OS ( p = 0.119), DSS ( p = 0.119), DMFS ( p = 0.201), and LRFS ( p = 0.125) than patients treated with CCD < 200 mg/m 2 . Conclusions: A CCD ≥ 200 mg/m 2 might result in better survival outcomes in stage N3 patients. Larger CCDs may be exclusively used in cases of regionally advanced disease to avoid rigorous toxicity.
A unique radioprotective effect of resolvin E1 reduces irradiation-induced damage to the inner ear by inhibiting the inflammatory response
Authors: Zhang Jie , Xu Anting , Niu Tingting , Liu Chengcheng , Zhang Yongju , Li Tao , Wang Jihua , Wang Yongjing , Sun Dianshui
Published: April 2020

Background In addition to the direct effects of irradiation, the induced inflammatory response may play an important role in the damage to the inner ear caused by radiotherapy for the treatment of head and neck cancers. Resolvin E1 has anti-inflammatory activity, acting by reducing neutrophil infiltration and proinflammatory cytokine expression. Therefore, in this study we sought to confirm whether the inflammation induced by irradiation was involved in damage to the inner ear after radiotherapy and to investigate the protective effect and underlying mechanism of resolvin E1 using mouse models. Methods A dose of resolvin E1 was delivered by intraperitoneal injection to mice before irradiation. Changes in the auditory brainstem response, relative balance ability, inner ear morphology and the expression levels of proinflammatory cytokines in the inner ear were analyzed on days 7 and 14 after irradiation and compared among three experimental groups. Results Morphological analysis of the inner ear showed severe damage to the cochlea and vestibule after irradiation. In contrast, damage to the cochlea and vestibule was significantly reduced in the resolvin E1-pretreated group, which nonetheless remained damaged compared to the wild-type group. Proinflammatory cytokines also showed expression patterns matching the morphological observations. Conclusions We believe that the inflammation induced by irradiation is involved in the damage to the inner ear caused by radiotherapy, and that resolvin E1 reduces the damage caused by irradiation to the inner ear by regulating the induced inflammatory response.
Optimized method for extraction of exosomes from human primary muscle cells
Authors: Gall Laura Le , Ouandaogo Zamalou Gisele , Anakor Ekene , Connolly Owen , Browne Gillian Butler , Laine Jeanne , Duddy William John , Duguez Stephanie
Published: April 2020

Skeletal muscle is increasingly considered as an endocrine organ secreting myokines and extracellular vesicles (exosomes and microvesicles), which can effect physiological changes with impact in different pathological conditions, including regenerative processes, aging and myopathies. Primary human myoblasts are an essential tool to study the muscle vesicle secretome . Since their differentiation in conditioned media does not induce any signs of cell death or cell stress, artefactual effects from those processes are unlikely. However, adult human primary myoblasts senesce in long-term tissue culture, so a major technical challenge is posed by the need to avoid artefactual effects resulting from pre-senescent changes. Since these cells should be studied within a strictly controlled pre-senescent division count (< 21 divisions), and yields of myoblasts per muscle biopsy are low, it is difficult or impossible to amplify sufficiently large cell numbers (some 250 x 10 6 myoblasts) to obtain sufficient conditioned medium for the standard ultracentrifugation approach to exosome isolation.
Thus an optimized strategy to extract and study secretory muscle vesicles is needed. In this study, conditions are optimized for the in vitro cultivation of human myoblasts, and the quality and yield of exosomes extracted using an ultracentrifugation protocol are compared with a modified polymer-based precipitation strategy combined with extra washing steps. Both vesicle extraction methods successfully enriched exosomes, as vesicles were positive for CD63, CD82, CD81, floated at identical density ( 1.15-1.27 g.ml -1 ), and exhibited similar size and cup-shape using electron microscopy and NanoSight tracking. However, the modified polymer-based precipitation was a more efficient strategy to extract exosomes, allowing their extraction in sufficient quantities to explore their content or to isolate a specific subpopulation, while requiring >30 times fewer differentiated myoblasts than what is required for the ultracentrifugation method. In addition, exosomes could still be integrated into recipient cells such as human myotubes or iPSC -derived motor neurons.
Modified polymer-based precipitation combined with extra washing steps optimizes exosome yield from a lower number of differentiated myoblasts and less conditioned medium, avoiding senescence and allowing the execution of multiple experiments without exhausting the proliferative capacity of the myoblasts.
High-throughput screening reveals novel mutations in spinal muscular atrophy patients
Authors: Zhang Ruiping , Gu Chunyu , Pu Linjie , Meng Yingtao , Shu Jianbo , Cai Chunquan
Published: April 2020

Background Spinal muscular atrophy (SMA) is an autosomal recessive hereditary disease associated with severe muscle atrophy and weakness in the limbs and trunk. The discovery of genes mutated by SMA is helpful in diagnosis and treatment. Methods 83 whole blood samples were collected from 28 core families of clinically suspected SMA, and multiplex ligation probe amplification (MLPA) was firstly performed. Afterwards, the complete gene sequence of SMN1 gene was detected. Furthermore, 20 SMA patients were selected from the 28 probands, and 5 non SMA children as controls. The Life Technologies SOLiD™ technology with mate-pair chemistry was utilized to conduct the whole exome high-throughput sequencing. Results 22 probands were SMA patients, 3 probands carriers, and 3 probands normal individuals. Moreover, 2 parents from 2 SMA families were with 3 SMN1 exon7 copies. 6 SMN1 single nucleotide variants (SNVs) were identified in the 83 samples, and c.[84C>T], c.[271C>T], c.[-39A>G] and g.[70240639G>C] were novel. Compared with control group, 9102 mutation were selected out in SMA patients. SPTA1 mutation c.[-41_-40insCTCT], FUT5 SNV c.[1001A>G], and MCCC2 SNV c.[-117A>G] were the 3 most frequent mutations in SMA group (95%, 85% and 75%, respectively). Conclusions We identified some mutations in both SMN1 and other genes, and c.[271C>T], c.[-41_-40insCTCT], c.[1001A>G] and c.[-117A>G] might be associated with the onset of SMA.
Post Occupancy Evaluation of Adaptively Reused Buildings: Case Study of an Office Building in Saudi Arabia
Authors: HAMIDA Mohammad B. , HASSANAIN Mohammad A.
Published: April 2020

Adaptive reuse of buildings is the practice of converting the use of an originally designed built-environment to suit a new use. This conversion process has a direct bearing on the performance of the building, and the satisfaction of the users with the conditions of the converted built-environment. This paper presents the findings of a post occupancy evaluation (POE) of an adaptively reused student housing facility to an office building, as a case study. The POE was conducted to investigate the consequences of the conversion process on the technical and functional elements of performance of the adapted building. A review of literature was performed to identify the technical and functional elements of performance pertaining to the new use of the building, along with their recommended performance criteria in codes and standards. The study employed multiple data collection methods, including a walkthrough tour to develop insights about the performance of the building elements; interviews to confirm the validity of the identified technical and functional performance elements, and initiate discussion with the users based on the findings of the walkthrough tour; and a user satisfaction survey to obtain the users’ feedback on the performance of the building. The findings of the study resulted in developing a series of recommendations to improve the performance of the case study building. The paper serves to guide design professionals involved in the planning and design of adaptive reuse projects, and facilities managers in charge of the daily operations of adaptively reused buildings.
TRPC3-Based Protein Signaling Complex as a Therapeutic Target of Myocardial Atrophy
Authors: Nishiyama Kazuhiro , Tanaka Tomohiro , Nishimura Akiyuki , Nishida Motohiro
Published: April 2020

Background:

Transient receptor potential (TRP) channels, especially canonical TRP channel subfamily
members 3 (TRPC3) and 6 (TRPC6), have attracted attention as a putative therapeutic target of heart
| 1
failure. Moreover, TRPC3 and TRPC6 channels are physiologically important for maintaining cellular
homeostasis. How TRPC3/C6 channels alter intracellular signaling from adaptation to maladaptation has
been discussed for many years. We recently showed that formation of a protein signal complex between
TRPC3 and NADPH oxidase (Nox) 2 caused by environmental stresses (e.g., hypoxia, nutritional
deficiency, and anticancer drug treatment) promotes Nox2-dependent reactive oxygen species production
and cardiac stiffness, including myocardial atrophy and interstitial fibrosis, in rodents. In fact,
pharmacological prevention of the TRPC3-Nox2 protein complex can maintain cardiac flexibility in mice
after anti-cancer drug treatment.

Conclusion:

In this mini-review, we discuss the relationship between TRPC3/C6 channels and
cardiovascular disease, and propose a new therapeutic strategy by focusing on pathology-specific protein–
protein interactions.
Influence of Biocompatible Coating on Titanium Surface Characteristics
Authors: Petrović Željka , Katić Jozefina , Šarić Ankica , Despotović Ines , Matijaković Nives , Kralj Damir , Leskovac Mirela , Petković Marin
Published: April 2020

Background:

Nowadays investigations in the field of dental implants engineering are focused
on bioactivity and osseointegration properties.

Objective:

In this study, the oxide-covered titanium was functionalized by vitamin D3 molecules via a
simple self-assembly method with the aim to design more corrosion-resistant and at the same time
more bioactive surface.

Methods:

Surface properties of the D3-coated titanium were examined by scanning electron microscopy,
attenuated total reflectance Fourier transform infrared spectroscopy, and contact angle measurements,
while long-term corrosion stability during immersion in an artificial saliva solution was
investigated in situ by electrochemical impedance spectroscopy.

Results:

Results of all techniques confirmed a successful formation of the vitamin D3 layer on the
oxide-covered titanium. Besides very good corrosion resistivity (~5 MΩ cm2), the D3-modified titanium
surface induced spontaneous formation of biocompatible bone-like calcium phosphates (CaP).

Conclusion:

Observed in vitro CaP-forming ability as a result of D3-modified titanium/artificial saliva
interactions could serve as a promising predictor of in vivo bioactivity of implant materials.
Гетероструктура 2D SiC/Si: электронные состояния и адсорбционная способность
Authors: Давыдов С.Ю. , Зубов А.В.
Published: April 2020

Abstract A model of a heterostructure consisting of a silicon-carbide single layer formed on a massive silicon substrate is proposed. The problem of the adsorption of alkali metal atoms and halogen atoms on the carbon and silicon surface atoms of a 2D SiC/Si heterostructure is considered. Analytical estimates for charge transfer and the adsorption energy are reported.
Ontologías: análisis de sus implementaciones en la bibliotecología
Authors: Suárez Sánchez Adriana
Published: April 2020

El objetivo del artículo es determinar las implementaciones que las ontologías tienen en la bibliotecología. La hipótesis inicial estableció que pueden funcionar como un sistema para la organización del conocimiento (SOC), con funciones similares a los encabezamientos de materia o los tesauros. La metodología empleada consistió en revisión bibliográfica y análisis de casos. Los resultados evidencian que las ontologías en la disciplina bibliotecología pueden implementarse en cinco funciones: 1) representación estructurada de dominios, 2) indización de recursos de información digitales, 3) generación de aprendizaje entre estudiantes y usuarios, 4) construcción de la web semántica, y 5) estructuración de redes de datos enlazados. A partir de los resultados, se confirmó que pueden ser empleadas como un SOC pero, además, pueden ser aplicadas en tareas generales para el modelado de datos o información en la web. Se concluye que son sistemas con alto potencial en la representación y organización de la información en contextos digitales.
Bütünleşik Entropi-EDAS Yöntemi ile Nakit Akım Odaklı Finansal Performans Analizi: BIST Orman, Kâğıt, Basım Endeksi’nde İşlem Gören Firmaların 2011-2018 Dönem Verisinden Kanıtlar
Authors: APAN Mehmet , ÖZTEL Ahmet
Published: April 2020

Bu çalışmada, Borsa İstanbul (BIST) Orman Kâğıt Basım Endeksi’nde işlem gören firmaların nakit akım odaklı finansal performansları Bütünleşik Entropi-EDAS yöntemi kullanılarak karşılaştırmalı analiz edilmiştir. Analizde kullanılan yöntemler karar verici veya uzman görüşüne ihtiyaç duymayan objektif yöntemler oldukları için tercih edilmişlerdir. Çalışma kapsamında endekste yer alan 15 adet firma alınmış ve finansal performanslarının belirlenmesi için 2011-2018 yıllarına ait veriler kullanılmıştır. Çalışmada değerlendirme kriteri olarak, literatürde nakit akım odaklı finansal performans analizlerinde yaygın olarak kullanılan 12 adet finansal oran (kriter) seçilmiş ve bu kriterler bilanço, gelir tablosu ve nakit akım tabloları yardımıyla hesaplanmıştır. İlk olarak Entropi yöntemi ile kriterlerin ağırlıkları belirlenmiş ve daha sonra EDAS yöntemi ile firmaların performansları sıralanmıştır. 2011-2018 periyodu Entropi ağırlıkları ortalamalarına göre, İşletme Faaliyetlerinden Nakit Akışları / Duran Varlıklar oranı, önem düzeyi en yüksek kriter olmuştur. EDAS yöntemiyle yapılan performans sıralamalarında, KARTN firması 2015 yılı haricinde diğer yıllarda gösterdiği yüksek performans ile tüm yıllar ortalamasında en başarılı firma olmuştur. GENTS firması ikinci olurken, SAMAT ve HURGZ sıralamada son sıralarda yer almışlardır.
Strategi Koping Pada Remaja dengan Kecenderungan Berperilaku Agresif
Authors: Rochwidowati Novia Sinta , Rismarini Nadya Anjani
Published: April 2020

Agression among teenagers, including bullying, school gangsters, and even students criminality, has been an issue for years. On the other hand, teenagers are expected to adapt well in society, to make healthy social relations, in order to become healthy and responsible adults. These developmental task takes a capability to adapt and overcome problems in everyday life, which is defined as coping strategy. This study aims to investigate the relationship between coping strategy and agrressive behavior in teenagers using Coping Strategy Scale for Teenagers and Aggressive Behavior Scale. The subjects were 416 students of middle and high schools in Bantul, Yogyakarta. Data were analyzed using Product Moment correlation test. The result showed that there was a negative correlation between coping strategy and aggressive behavior in teenagers (r= -0,287; p<0,01). Teenagers who had better ability to cope with stressful events demonstrated less aggressive behavior.
Hubungan Kebermaknaan Hidup dan Keteraturan Melaksanakan Shalat dengan Psycholohycal Well-Being pada Mahasiswa
Authors: Yulianti Iin , Cahyani Regita
Published: April 2020

PPsychologycal well-being affects mental health, social functioning, interpersonal relationships, health, and adaptability. There are several factors that influence psychologycal well-being, such as meaning, purpose in life, and religiosity. The purpose of this study was to determine the relationship between the meaningfulness of life and the regularity of praying with psychologycal well-being in the 2016 class year students at the Faculty of Usuluddin and Religious Studies of UIN Raden Intan Lampung. The hypothesis proposed in this study is that there is a relationship between the meaningfulness of life and the regularity of praying with psychologycal well-being in students. The subjects in this study were students in 2016 at the Faculty of Islamic Studies and Religious Studies of UIN Raden Intan Lampung totaling 70 people taken by propotionate random sampling technique. Data collection methods in this study used three psychological scales namely the psychological well-being scale with 33 items (α = 0.889), the scale of meaningfulness of life with 25 items (α = 0.843) and the regular scale for praying with 49 items (α = 0.958). The data that has been collected is then analyzed using multiple regression analysis techniques assisted by the SPSS 21.0 for Windows program. The results showed that Rx1.2y = 0.530 with a value of F = 13.082 with p = 0.000 (p <0.01) which means the hypothesis is accepted that there is a significant positive relationship between the meaningfulness of life and the regularity of prayer with psychologycal well-being in students with R2 = 0.281. The ability of life and regular prayers contributed 28.1% to psychologycal well-being. The second result with rx1y = 0.302 with p = 0.011 (p <0.05) which showed a significant positive relationship between meaningfulness of life with psychologycal well-being in the 2016 class year students at the Faculty of Usuluddin and Religious Studies of UIN Raden Intan Lampung. The third result with rx2y = 0.518 with p = 0,000 (p <0.05) which shows a significant positive relationship between the regularity of prayer and psychologycal well-being in students.
Kontroversi Surat Al-Fatihah Dalam Pandangan Arthur Jeffery
Authors: Dhulkifli Muhammad Luthfi
Published: April 2020

AbstractAmongst some orientalist of Qur’anic studies, Arthur Jeffery was one of the controversial figures for the idea of a critical edition of the Qur’an. For Jeffery, the Qur’an existed today is unreasonable and its arrangement is clearly haphazard. One of his critical argument is surah al-Fatihah which indicated not originally part of the Qur’an. His work “the variant readings of the Fatihah” showed some peculiar nature of al-Fatiha with the evidence of two Fatihah different versions. Jeffery’s variants study is a polemical argument as its contradicts to the Muslim scholar arguments. For Muslim scholars, al-Fatihah is an integrated part of Qur’an. Therefore, this article will analyze Jeffery’s argument on al-Fatihah through a descriptive-analytic method. Based on historical, language, and qira’ah study, Jeffery’s argument is incorrect. In addition, Jeffery failed to show the existence of his evidence of variant of al-Fatihah.Keywords: Critic; Controversy; Fatiha; Muslim; the Qur’an  AbstrakDiantara sekian banyak para orientalis pengkaji al-Qur’an, Arthur Jeffery merupakan salah satu sosok yang paling kontroversial dengan gagasannya untuk membuat al-Qur’an edisi kritis. Menurut Jeffery, al-Qur’an yang ada saat ini sangat tidak jelas dan susunannya dilakukan secara sembarangan. Salah satu bagian yang Jeffery kritisi adalah surat al-Fatihah yang dianggap bukan bagian dari al-Qur’an. Dalam tulisannya yang berjudul the variant readings of the Fatihah, dia menunjukkan kejanggalan dalam surat al-Fatihah dengan menunjukkan bukti dua variasi surat al-Fatihah yang berbeda. Kajian ini mengundang polemik karena bertentangan dengan pandangan para sarjana Muslim yang menganggap al-Fatihah sebagai bagian penting dari al-Qur’an. Tulisan ini akan menganalisasi pandangan Jeffery terhadap surat al-Fatihah melalui metode deskriptif-analitis. Melalui kajian historis, kebahasaan, dan ilmu qira’at, argumen skeptis Jeffery terhadap al-Fatihah terbantahkan. Ditambah lagi, Jeffery tidak mampu membuktikan keberadaan variasi surat al-Fatihah yang dia yakini.  Kata Kunci: al-Fatihah; al-Qur’an; Kontroversi; Kritik; Muslim
IMPLEMENTASI MA’NA CUM MAGHZA TERHADAP MAKNA GULUL DALAM AL-QUR’AN (Interpretasi QS. Ali Imran: 161)
Authors: Asna Hanifatul
Published: April 2020

AbstractThe Qur’an as the first source of reference for Muslims who are always relevant in every time and place, must have an informative meaning. It can undergo meaningful transformation in line with changing times. In the time of the Prophet, the word gulūl was understood by taking war booty before it was distributed. Wherwas current context war like during the time of the Prophet is no longer happening, it is necessary to re-interpret what the meaning of gulūl along with how to contextualize the use of the word in the Qur’an especially in the QS. Ali Imrān: 161. By using the Hermeneutic approach, this specifically borrows Abdullah Saeed’s Contextual theory in understanding the meaning of gulūl in the Qur’an especially QS. Ali Imrān; 161, then an interpretation can be produced between them; first, in the initial context gulūl was a form of betrayal, like taking the spoils of war. Secondly, in the current context gulūl can be understood with broad meanings of betrayal such as being unsafe and taking things secretly even though he has the right part of the thing. This can be described as corruption both material and time. The essence of Q.S Ali Imrān: 161, it can be interpreted a leader is not possible and should not do gulūl (acts of cheating). This verse shows the existence of protection values. AbstrakAl-Qur’an sebagai sumber rujukan pertama umat muslim yang selalu relevan dalam setiap waktu dan tempat, pastilah mempunyai makna informatif dan dapat mengalami transformasi pemaknaan seiring dengan perubahan zaman. Pada zaman Nabi, kata gulūl dipahami dengan mengambil harta rampasan perang sebelum dibagikan. Sedangkan pada konteks sekarang, perang seperti pada masa Nabi sudah tidak lagi terjadi. Oleh karenanya, perlu adanya interpretasi ulang apa makna gulūl serta bagaimana kontekstualisasi penggunaan kata tersebut dalam al-Qur’an khususnya pada QS. Ali Imrān: 161. Dengan menggunakan pendekatan Hermeneutika, khususnya meminjam teori Kontekstual Abdullah Saeed dalam memahami makna gulūl dalam al-Qur’an khususnya QS. Ali Imrān ayat 161, maka dapat dihasilkan interpretasi di antaranya; pertama, dalam konteks awal gulūl merupakan bentuk pengkhianatan, seperti mengambil harta rampasan perang. Kedua, dalam konteks saat ini gulūl dapat dipahami dengan makna khianat secara luas seperti tidak amanah dan mengambil sesuatu secara sembunyi-sembunyi meskipun dia mempunyai bagian hak dari benda tersebut. Hal ini dapat digambarkan seperti korupsi secara materi maupun waktu. Adapun intisari QS. Ali Imrān: 161, dapat diartikan seorang pemimpin tidak mungkin dan tidak seharusnya melakukakan gulūl (tindak kecurangan). Ayat ini menunjukkan adanya nilai-nilai perlindungan/protectional values.Kata Kunci: Gulūl, Hermeneutika, Kontekstual, QS. Ali Imrān: 161
Toward Theology of Science: Philosophical Reflection On The Development Of Religion-Based Science
Authors: Muslih Mohammad
Published: April 2020

The relationship between science and religion is one of the issues that has not been resolved completely until now. Although some universities in Indonesia and even Malaysia have developed academic traditions with the paradigm of integration of science, they still leave a fundamental problem related to aspects of scientific science developed with religion. To meet scientific and objective criteria, science must avoid the element of subjectivity of scientists, and eliminate the intersubjectivity of tradition and culture. This paper will analyze, especially to emphasize the position of philosophy in the development of religion-based science, as well as reflection for the development of philosophical sciences. This paper will discuss two main problems, the investigation of the religious dimension for science, and the role of religion-based science development for the development of philosophical sciences. The study found that in addition to the theoretical framework and scientific paradigm, there is one more thing that cannot be left behind in the process of developing science, namely the theological assumptions or theological dimensions of science. So that the basis of the development of science not only consists of theories and paradigms, but also theological assumptions. This article concludes that the theological dimension allows for the development of religion-based science.
PENGEMBANGAN SOFTSKILL TEKNOLOGI PEMBELAJARAN MELALUI PEMBUATAN E-MODUL BAGI GURU SEKOLAH DASAR
Authors: Kuncahyono Kuncahyono , Kumalasani Maharani Putri
Published: April 2020

Tujuan penelitian ini untuk membantu mitra dalam meningkatkan kompetensi dan digital skill guru sekolah dasar Muhammadiyah 5 Malang sebagai upaya penerapan digitalisasi pembelajaran. Metode penelitian yang digunakan menggunakan pendekatan participatory action  research (PAR). Metode kegiatan ini dilakukan berbasis riset dengan cara 1) melakukan sosialisasi dan workshop digitalisasi pembelajaran, 2) penyusunan aplikasi e-modul berbasis komputer, 3) implementasi produk e-modul dalam pembelajaran. Hasil kegiatan berbasis riset yaitu 1) menghasilkan produk aplikasi e-modul yang mampu meminimalisir penggunaan kertas (paperless) baik untuk mengemas materi pembelajaran, maupun dalam penggunaan kertas soal-soal ujian, 2) peningkatan hasil pretest dan posttest dalam pengetahuan dan keterampilan guru dalam pembuatan e-modul. Hasil akhir menunjukkan sebagai produk akhir dari pembuatan media e-modul  yaitu produk media e-modul  dan Implementasi media e-modul  (modul digital) pada pembelajaran. Guru-guru dapat mengimplementasikan produk e-modul (modul digital) yang telah dibuat pada tahap sebelumnya dan direalisasikan dalam kegiatan pembelajaran.
Dilemmas Between the General and Particular Will – A Hegelian Analysis
Authors: Blum Christian
Published: April 2020

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Hegel e il nostro tempo: Riflessioni sulla mala infinità
Authors: Serra Teresa
Published: April 2020

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Bioética. El contexto político
Authors: López de la Vieja M. Teresa
Published: April 2020

RESUMENEl artículo argumenta en favor de un enfoque político de la Bioética. Por entender que el discurso bioético tendrá un alcance global solo después de revisar sus compromisos básicos e ideología. En los años setenta, Liberalismo y Pragmatismo dejaron su impronta en la disciplina. De un lado, el papel central de la autonomía estaba relacionado con los valores de la Nueva frontera políticaM de otro el Pragmatismo, la "ideología americana", derivó hacia el giro aplicado en Ética. al comienzo, la Bioética pretendía al acuerdo entre valores morales y ciencia, siendo un "puente" hacia el futuro. Sin embargo el consenso como valor prioritario desaconsejaba los debates políticos. Por esta razón, la Bioética se distanció del movimiento a favor de los derechos civiles. En beneficio de la imparcialidad liberal, la disciplina tuvo que redefinir fronteras, hacia dentro y hacia fuera. El modelo científico prevaleció sobre el modelo político. Pero el pragmatismo en cuestiones científicas era problemático. En los años noventa, el "Informe final" de la Comisión encargaba de investifar los hechos (ACHRE) demostró los experimentos con humanos habían ignorado los estándares morales y los derechos de los pacientes. En Estados Unidos.PALABRAS CLAVEBIOÉTICA, ÉTICA DE LA INVESTIGACIÓN CIENTÍFICA, IDEOLOGÍA, DERECHOS DE LOS CIUDADANOSABSTRACTthe article argues in favour of a political perspective about Bioethics, thinking that global discourse would expand at a global level only after the re-examination of basic commitments and ideology. Liberalism and Pragmatism imprinted their traces over the discipline the seventies. On the one hand the central role of autonomy was related to the values of the New frontier in politicis. On the other hand Pragmatism, the "American ideology", produced the practical turn in Ethics. At first, Bioethics aimed the consensus between moral values and sciencie, being like a "bridge" to the future. Consensus as a supreme value discouraged political debates, though. For that reason, Bioethics disentangled itself from the civil right movements. Fot he sake of liberal impartiality, the bioethical discourse had to adjust Pragmatism in scientific issues was flawed. The "Final Report of the Committee" (ACHRE) in charge of the investifation proved in the nineties that experimentation on humans had ignored moral standards and patients rights. In the United States.KEYWORDSBIOETHICS, ETHICS OF SCIENCE, IDEOLOGY, CITIZENS RIGHTS
Republicanismo y teoría de las capacidades. El debate entre P. Pettit y A. Sen sobre la libertad
Authors: Cejudo Córdoba Rafael
Published: April 2020

RESUMENLa teoría de la libertad de A. Sen resulta de la conjunción de sus enfoques de las capacidades, de las habilitaciones (entitlements) y de la elección social. De esta manera se obtiene una noción de libertad como capacidad que puede compararse con la libertad como ausencia de dominación característica del republicanismo. El resultado de tal comparación es, contra la tesis de P. Pettit, una diferencia importante entre ambas debido a las dificultades de la concepción seniana para captar las relaciones de poder.PALABRAS CLAVEPETTIT, A. SEN, PODER, REPUBLICANISMO, CAPACIDAD, LIBERAL PARETIANO, HABILITACIÓN (ENTITLEMENT)ABSTRACTAmartya Sen’s theory of freedom emerges from his capabilities approach, his entitlements approach and his contributions to the theory of social election. In this way we get a concept of freedom as capability which can be compared to the republican notion of liberty as non domination. Against P. Pettit’s view, we deduce of this comparison an important difference between both theories of freedom. That difference is due to the difficulties of Sen’s theory to cope with the relations of power.KEY-WORDSPETTIT, A. SEN, REPUBLICANISMO, CAPABILITY, POWER, PARETIAN LIBERAL, ENTITLEMENT
Deleuze y Zubiri… en torno a una lógica de la impresión*
Authors: Espinoza Lolas Ricardo A.
Published: April 2020

RESUMENEste artículo es un intento de pensar lo que es el cuerpo a la luz de las filosofías de Gilles Deleuze y de Xavier Zubiri. Ambos pensadores han sido muy radicales en sus posiciones respecto al papel del sentir. A veces es más conocido, para algunos, el pensamiento deleuziano en torno al cuerpo y las sensaciones, pero la reflexión zubiriana es también una filosofía del cuerpo que a veces no ha sido atendida en su profundidad. Además, vemos que ambos pensadores tienen muchos puntos en común; uno de ellos es el denominado «Cuerpo sin órganos». Desde esta categoría deleuziana se indicará la proximidad con la filosofía zubiriana y con ello la importancia que cobra el cuerpo en una filosofía para los tiempos actuales.PALABRAS CLAVEDELEUZE, ZUBIRI, LÓGICA, IMPRESIÓN, SENSACIÓN, CUERPO SIN ÓRGANOS, INTELIGENCIA SENTIENTE.ABSTRACTThis article attempts to think what the body is from the perspective of the philosophy of Gilles Deleuze and also from Xavier Zubiri. Both thinkers have been totally radicals in their positions concerning the role of sensations. It may sound more natural, for some, to associate Deleuze’s thought on body and sensations than that of Zubiri; but we have to acknowledge that the latter’s thought is also a philosophy of the body and, therefore, we shall attend it in its whole depth. Moreover, we have to recognize that both thinkers have lots of common points, one of them the so-called «Body without organs». From this deleuzian category will be indicated the proximity between deleuzian and zubirian philosophy; and with that the importance that acquires the body in a philosophy worth of our times.KEY WORDSDELEUZE, ZUBIRI, LOGIC, IMPRESSION, SENSATION, BODY WITHOUT ORGANS, SENTIENT INTELLIGENCE