bluuebunny/crossref_metadata_2025 huggingface dataset:
Building the Social Acceptability of Aquaculture through a Participatory Approach: An Experiment Conducted in Monastir Bay, Tunisia
Authors: Pérez Agúndez José Antonio , Raux Pascal , Lancelot Loeiza , Rougier Jean-Emmanuel
Published: July 2024

Aquaculture development is a challenge for the economic growth of coastal territories and to promote the food security of their populations. Many efforts have been made by international, national, and local public institutions to develop this sector. Despite this political objective, the coastal zones of Europe and the Mediterranean in general are faced with problems that strongly limit this development. This is linked to several factors, including social opposition, which raises the question of the social acceptability of aquaculture development. Beyond understanding the factors that explain the social rejection of this sector or its products, the key question concerns the capacity of private and public institutions to deal with this social opposition in a practical way. Based on fieldwork and a participatory approach, this paper analyzes the constraints of aquaculture development in Monastir Bay, Tunisia, and in particular, those relying on social dimensions. Under this participatory approach, the authors propose a research–action framework allowing the building of bases for engaging stakeholders in a co-construction process of a shared vision of aquaculture development in Monastir, in accordance with the constraints and ambitions expressed by the local communities regarding territorial needs. This paper shows the value of building the transition from an individual or group vision to a collective vision through a participatory approach that is likely to form a consensus, as opposed to an aggregation of individual visions that can lead to social unacceptance. It also argues that involving citizens in the exploration of aquaculture development scenarios adapted to the territory is an essential prerequisite to exploring the conditions that question the social acceptability and its improvement.
A Hybrid Extended Kalman Filter Based on Parametrized ANNs for the Improvement of the Forecasts of Numerical Weather and Wave Prediction Models
Authors: Donas Athanasios , Galanis George , Pytharoulis Ioannis , Famelis Ioannis Th.
Published: July 2024

A hybrid optimization filter for weather and wave numerical models is proposed and tested in this study. Parametrized Artificial Neural Networks are utilized in conjunction with Extended Kalman Filters to provide a novel postprocess strategy for 10 m wind speed, 2 m air temperature, and significant wave height simulations. The innovation of the developed model is the implementation of Feedforward Neural Networks and Radial Basis Function Neural Networks as estimators of an exogenous parameter that adjusts the covariance matrices of the Extended Kalman Filter process. This hybrid system is evaluated through a time window process leading to promising results, thus enabling a decrease in systematic errors alongside the restriction of the error variability and the corresponding forecast uncertainty. The obtained results showed that the average reduction of the systematic error exceeded 75%, while the corresponding nonsystematic part of that error decreased by 35%.
Influences of Fermentation Conditions on the Chemical Composition of Red Dragon Fruit (Hylocereus polyrhizus) Wine
Authors: Ngoc Truong , Thinh Pham , Mui Dang , Uyen Le , Ngan Nguyen , Tran Ngo , Khang Pham , Huy Le , Minh Truong , Trung Nguyen
Published: July 2024

Red dragon fruit (Hylocereus polyrhizus), recognized globally for its substantial nutrient content and health benefits, has been extensively studied; studies have particularly focused on the fruit, while the composition of the stem remains less explored. This research focuses on optimizing fermentation parameters for red dragon fruit wine, specifically examining yeast-strain selection, juice-to-water dilution ratios, and yeast concentrations. Saccharomyces cerevisiae RV002 emerged as the optimal strain due to its robust performance and adaptability under adverse conditions. The study identified a 50% dilution ratio as ideal for maximizing clarity and the sensory attributes of the wine, whereas dilution ratios exceeding 90% significantly reduced ethanol content below acceptable commercial standards. An optimal yeast concentration of 1 g/L was found to balance microbial suppression and alcohol yield effectively; deviations from this concentration led to microbial contamination or impaired fermentation dynamics. Fermentation markedly altered the biochemical properties of Hylocereus polyrhizus, reducing sugar and vitamin C levels while increasing polyphenol content and antioxidant activity, thereby enhancing potential health benefits. These findings underscore the transformative effects of microbial activity on the substrate’s chemical landscape and highlight the potential of tailored fermentation strategies to enhance the utility and value of underutilized fruits in sustainable agricultural practices.
Electrochemical Impedance Spectroscopy in the Determination of the Dielectric Properties of Tau-441 Protein for Dielectrophoresis Response Prediction
Authors: Shee Da En Zuriel , Mhd Noor Ervina Efzan , Ahmed Kayani Aminuddin , Hussin Mohd Hazwan , Farrukh Baig Mirza
Published: July 2024

This study employs electrochemical impedance spectroscopy (EIS) to probe the behavior of Tau-441 protein, a key component implicated in Alzheimer’s disease. Through meticulous experimentation and analysis, the impedance of Tau-441 protein suspension revealed a conductivity peak value of 1.02 S/m. The study demonstrates a high level of specificity and selectivity, particularly within the challenging nanomolar concentration range. Additionally, the EIS method enabled the prediction of Tau-441 protein’s dielectrophoresis (DEP) response and the determination of the associated frequency range of 1 kHz to 1 MHz. These findings contribute to advancing our understanding of the molecular intricacies surrounding Tau-441 and hold promise for unraveling implications related to Alzheimer’s disease. This study establishes a robust foundation for future research on neurodegenerative disease and biosciences, offering valuable insights into the electrochemical dynamics of Tau-441 protein.
The Potential of a New Natural Vessel Source: Decellularized Intercostal Arteries as Sufficiently Long Small-Diameter Vascular Grafts
Authors: Xia Yuan , Zhou Haiyun , Ou Jing-Song , Liu Yunqi
Published: July 2024

Small-diameter vascular grafts (SDVGs) are severely lacking in clinical settings. Therefore, our study investigates a new source of biological vessels—bovine and porcine decellularized intercostal arteries (DIAs)—as potential SDVGs. We utilized a combination of SDS and Triton X-100 to perfuse the DIAs, establishing two different time protocols. The results show that perfusing with 1% concentrations of each decellularizing agent for 48 h yields DIAs with excellent biocompatibility and mechanical properties. The porcine decellularized intercostal arteries (PDIAs) we obtained had a length of approximately 14 cm and a diameter of about 1.5 mm, while the bovine decellularized intercostal arteries (BDIAs) were about 29 cm long with a diameter of approximately 2.2 mm. Although the lengths and diameters of both the PDIAs and BDIAs are suited for coronary artery bypass grafting (CABG), as the typical diameter of autologous arteries used in CABG is about 2 mm and the grafts required are at least 10 cm long, our research indicates that BDIAs possess more ideal mechanical characteristics for CABG than PDIAs, showing significant potential. Further enhancements may be necessary to address their limited hemocompatibility.
Integrating Convolutional Neural Networks with Attention Mechanisms for Magnetic Resonance Imaging-Based Classification of Brain Tumors
Authors: Rasheed Zahid , Ma Yong-Kui , Ullah Inam , Al-Khasawneh Mahmoud , Almutairi Sulaiman Sulmi , Abohashrh Mohammed
Published: July 2024

The application of magnetic resonance imaging (MRI) in the classification of brain tumors is constrained by the complex and time-consuming characteristics of traditional diagnostics procedures, mainly because of the need for a thorough assessment across several regions. Nevertheless, advancements in deep learning (DL) have facilitated the development of an automated system that improves the identification and assessment of medical images, effectively addressing these difficulties. Convolutional neural networks (CNNs) have emerged as steadfast tools for image classification and visual perception. This study introduces an innovative approach that combines CNNs with a hybrid attention mechanism to classify primary brain tumors, including glioma, meningioma, pituitary, and no-tumor cases. The proposed algorithm was rigorously tested with benchmark data from well-documented sources in the literature. It was evaluated alongside established pre-trained models such as Xception, ResNet50V2, Densenet201, ResNet101V2, and DenseNet169. The performance metrics of the proposed method were remarkable, demonstrating classification accuracy of 98.33%, precision and recall of 98.30%, and F1-score of 98.20%. The experimental finding highlights the superior performance of the new approach in identifying the most frequent types of brain tumors. Furthermore, the method shows excellent generalization capabilities, making it an invaluable tool for healthcare in diagnosing brain conditions accurately and efficiently.
Mixture Theory-Based Finite Element Approach for Analyzing the Edematous Condition of Biological Soft Tissues
Authors: Hirabayashi Satoko , Iwamoto Masami , Chen Xian
Published: July 2024

In hydrated soft biological tissues experiencing edema, which is typically associated with various disorders, excessive fluid accumulates and is encapsulated by impermeable membranes. In certain cases of edema, an indentation induced by pressure persists even after the load is removed. The depth and duration of this indentation are used to assess the treatment response. This study presents a mixture theory-based approach to analyzing the edematous condition. The finite element analysis formulation was grounded in mixture theory, with the solid displacement, pore water pressure, and fluid relative velocity as the unknown variables. To ensure tangential fluid flow at the surface of tissues with complex shapes, we transformed the coordinates of the fluid velocity vector at each time step and node, allowing for the incorporation of the transmembrane component of fluid flow as a Dirichlet boundary condition. Using this proposed method, we successfully replicated the distinct behavior of pitting edema, which is characterized by a prolonged recovery time from indentation. Consequently, the proposed method offers valuable insights into the finite element analysis of the edematous condition in biological tissues.
Difficult Airway Assessment Based on Multi-View Metric Learning
Authors: Wu Jinze , Yao Yuan , Zhang Guangchao , Li Xiaofan , Peng Bo
Published: July 2024

The preoperative assessment of difficult airways is of great significance in the practice of anesthesia intubation. In recent years, although a large number of difficult airway recognition algorithms have been investigated, defects such as low recognition accuracy and poor recognition reliability still exist. In this paper, we propose a Dual-Path Multi-View Fusion Network (DMF-Net) based on multi-view metric learning, which aims to predict difficult airways through multi-view facial images of patients. DMF-Net adopts a dual-path structure to extract features by grouping the frontal and lateral images of the patients. Meanwhile, a Multi-Scale Feature Fusion Module and a Hybrid Co-Attention Module are designed to improve the feature representation ability of the model. Consistency loss and complementarity loss are utilized fully for the complementarity and consistency of information between multi-view data. Combined with Focal Loss, information bias is effectively avoided. Experimental validation illustrates the effectiveness of the proposed method, with the accuracy, specificity, sensitivity, and F1 score reaching 77.92%, 75.62%, 82.50%, and 71.35%, respectively. Compared with methods such as clinical bedside screening tests and existing artificial intelligence-based methods, our method is more accurate and reliable and can provide a reliable auxiliary tool for clinical healthcare personnel to effectively improve the accuracy and reliability of preoperative difficult airway assessments. The proposed network can help to identify and assess the risk of difficult airways in patients before surgery and reduce the incidence of postoperative complications.
Single versus Double Plate Fixation in Condylar Neck Fractures: Clinical Results and Biomechanics Simulation
Authors: Chen Chien-Chung , Chiu Ting-Han , Yan Cheng-Yu , Hou Ya-Pei , Lin Ting-Sheng
Published: July 2024

The open reduction of mandibular condyle neck fractures is difficult due to the limited surgical field and complex facial nerve structures. The most effective fixation method for narrow fractured segments is debated as standard double four-hole plate fixation is often not feasible. This research compared bone stability and force resistance between single-long-plate and double-short-plate fixations using clinical outcomes, a Sawbones mandible model, and finite element analysis. In patients with condyle neck fractures, nine were fixed with single-long-plate and twelve with double-short-plate fixations, with no significant differences in malocclusion and facial palsy rates. In compression tests with a Sawbones model, displacements in the posterior part were similar in both fixation groups. In contrast, the anterior part had significantly higher displacements in the single-long-plate group. Finite element analysis showed higher displacements in both anterior and posterior parts in the single-plate group compared to the double-short-plate group. Maximum stresses were at the second screw hole in single-long-plate fixation and the turning point of the upper plate at the condyle neck in double-short-plate fixation. Double-short-plate fixations demonstrated better stability and force resistance than single-long-plate fixations.
Emerging Biomedical and Clinical Applications of 3D-Printed Poly(Lactic Acid)-Based Devices and Delivery Systems
Authors: Barcena Allan John R. , Ravi Prashanth , Kundu Suprateek , Tappa Karthik
Published: July 2024

Poly(lactic acid) (PLA) is widely used in the field of medicine due to its biocompatibility, versatility, and cost-effectiveness. Three-dimensional (3D) printing or the systematic deposition of PLA in layers has enabled the fabrication of customized scaffolds for various biomedical and clinical applications. In tissue engineering and regenerative medicine, 3D-printed PLA has been mostly used to generate bone tissue scaffolds, typically in combination with different polymers and ceramics. PLA’s versatility has also allowed the development of drug-eluting constructs for the controlled release of various agents, such as antibiotics, antivirals, anti-hypertensives, chemotherapeutics, hormones, and vitamins. Additionally, 3D-printed PLA has recently been used to develop diagnostic electrodes, prostheses, orthoses, surgical instruments, and radiotherapy devices. PLA has provided a cost-effective, accessible, and safer means of improving patient care through surgical and dosimetry guides, as well as enhancing medical education through training models and simulators. Overall, the widespread use of 3D-printed PLA in biomedical and clinical settings is expected to persistently stimulate biomedical innovation and revolutionize patient care and healthcare delivery.
Ultrasound Elastography Assessment of Knee Intra-Articular Adhesions at Varying Knee Angles
Authors: Ye Jiling , Peng Linjing , Ding Angang , Chen Shijie , Cai Bin , Yao Yifei
Published: July 2024

We aimed to verify the feasibility of using shear wave elastography (SWE) to quantify knee scars and the elastic modulus of scar tissues. Overall, 16 participants underwent SWE assessments and range-of-motion measurement and completed the Knee Injury and Osteoarthritis Outcome Score. The inter-rater reliability for SWE in the suprapatellar bursa, below the patellar tendon, and in the medial and lateral trochlear groove remained within 0.861–0.907. The SWE values in the four regions increased with increasing knee angle, and significant differences were observed between the values for below the patellar tendon and the suprapatellar bursa at knee flexion angles of 60° and 90°. The SWE values of the medial and lateral trochlear groove at 30°, 60°, and 90° knee flexion were higher on the affected side. A negative correlation was observed between the SWE values for the lateral trochlear groove at 0°, 30°, and 60° and those for below the patellar tendon at 0° and the suprapatellar bursa at 30° with both active and passive knee extension. The suprapatellar bursa value at 60° exhibited a positive correlation with both knee flexion and passive knee flexion, whereas that of the suprapatellar bursa at 90° exhibited a positive correlation with both the range of motion and passive range of motion. SWE is a replicable and effective method for detecting scar strength in the knee joint.
Routinely Used and Emerging Diagnostic and Immunotherapeutic Approaches for Wheat Allergy
Authors: Zheng Wanqi , Wai Christine Yee Yan , Sit Jason Ka Chun , Cheng Nam Sze , Leung Christy Wing Man , Leung Ting Fan
Published: July 2024

Wheat, a component of the staple diet globally, is a common food allergen in children. The symptoms of wheat allergy (WA) range from skin rash to shortness of breath, significantly impairing quality of life. Following initial clinical suspicion, individuals may undergo routinely used allergy tests such as a wheat allergen-specific skin prick test (SPT), a blood test for specific immunoglobulin E (sIgE) levels, or oral food challenge. Conventional management of WA lies in wheat avoidance, yet accidental consumption may be inevitable owing to the ubiquity of wheat in various food products. This article aims to provide an overview of the immunologic pathway of WA, followed by its emerging diagnostic methods, namely alcohol-soluble SPT extracts, component-resolved diagnosis, and the basophil activation test (BAT). The mechanisms underlying wheat allergen-specific oral immunotherapy (OIT) as well as a summary of the efficacy, tolerability, and safety of related clinical trials will then be discussed.
Deciphering the Reactivity of Autoantibodies Directed against the RNP-A, -C and 70 kDa Components of the U1-snRNP Complex: “Double or Nothing”?
Authors: Bertin Daniel , Babacci Benjamin , Brodovitch Alexandre , Dubrou Cléa , Heim Xavier , Mege Jean Louis , Bardin Nathalie
Published: July 2024

Background: The positivity of anti-RNP autoantibodies as biological criteria for the diagnosis of mixed connective tissue disease (MCTD) has recently divided the rheumatology community. Autoantigenicity of the U1-snRNP complex tends to generate multiple autoantibodies against RNP-A, -C and -70 KDa or Sm proteins. The aim of this study is to identify the most informative autoantibodies in clinical practice, in particular, to contribute to differential diagnosis between MCTD and systemic lupus erythematosus (SLE). Methods: Sera from 74 patients positive for anti-RNP autoantibodies were selected over a period of one year of laboratory practice. Autoantibodies directed against extractable nuclear antigen, RNP proteins (A, C, 70 KDa) and 40 kDa fragments of RNP-70 KDa were investigated by using quantitative fluoroenzymatic assay and Western blot analysis. Results: Among the 74 patients, 40 patients were diagnosed with SLE, 20 with MCTD, six with another autoimmune disease, three with SARS-CoV-2 infection, three with cancer and two were healthy. No preferential clinical association of IgG or IgM autoantibodies directed against each of the RNP proteins was found between SLE and MCTD. In contrast, the proportion of autoantibodies directed against the RNP component within the U1-snRNP complex showed a significantly higher RNP index in patients with MCTD than in those with SLE (p = 0.011), with good performance (sensitivity: 69.2%, specificity: 88.9%). Conclusions: The analysis of the proportion of the different autoantibodies directed against the U1-snRNP complex is more informative than the analysis of each autoantibody separately. A follow-up of patients could be informative about the interest of the RNP index as a predictor of disease evolution.
Effects of Transcutaneous Auricular Vagus Nerve Stimulation on the P300: Do Stimulation Duration and Stimulation Type Matter?
Authors: Giraudier Manon , Ventura-Bort Carlos , Weymar Mathias
Published: July 2024

Non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) has attracted increasing interest as a neurostimulation tool with potential applications in modulating cognitive processes such as attention and memory, possibly through the modulation of the locus–coeruleus noradrenaline system. Studies examining the P300 brain-related component as a correlate of noradrenergic activity, however, have yielded inconsistent findings, possibly due to differences in stimulation parameters, thus necessitating further investigation. In this event-related potential study involving 61 participants, therefore, we examined how changes in taVNS parameters, specifically stimulation type (interval vs. continuous stimulation) and duration, influence P300 amplitudes during a visual novelty oddball task. Although no effects of stimulation were found over the whole cluster and time window of the P300, cluster-based permutation tests revealed a distinct impact of taVNS on the P300 response for a small electrode cluster, characterized by larger amplitudes observed for easy targets (i.e., stimuli that are easily discernible from standards) following taVNS compared to sham stimulation. Notably, our findings suggested that the type of stimulation significantly modulated taVNS effects on the P300, with continuous stimulation showing larger P300 differences (taVNS vs. sham) for hard targets and standards compared to interval stimulation. We observed no interaction effects of stimulation duration on the target-related P300. While our findings align with previous research, further investigation is warranted to fully elucidate the influence of taVNS on the P300 component and its potential utility as a reliable marker for neuromodulation in this field.
The Role of Non-Invasive Brain Modulation in Identifying Disease Biomarkers for Diagnostic and Therapeutic Purposes in Parkinsonism
Authors: Birreci Daniele , De Riggi Martina , Costa Davide , Angelini Luca , Cannavacciuolo Antonio , Passaretti Massimiliano , Paparella Giulia , Guerra Andrea , Bologna Matteo
Published: July 2024

Over the past three decades, substantial advancements have occurred in non-invasive brain stimulation (NIBS). These developments encompass various non-invasive techniques aimed at modulating brain function. Among the most widely utilized methods today are transcranial magnetic stimulation (TMS) and transcranial electrical stimulation (TES), which include direct- or alternating-current transcranial stimulation (tDCS/tACS). In addition to these established techniques, newer modalities have emerged, broadening the scope of non-invasive neuromodulation approaches available for research and clinical applications in movement disorders, particularly for Parkinson’s disease (PD) and, to a lesser extent, atypical Parkinsonism (AP). All NIBS techniques offer the opportunity to explore a wide range of neurophysiological mechanisms and exert influence over distinct brain regions implicated in the pathophysiology of Parkinsonism. This paper’s first aim is to provide a brief overview of the historical background and underlying physiological principles of primary NIBS techniques, focusing on their translational relevance. It aims to shed light on the potential identification of biomarkers for diagnostic and therapeutic purposes, by summarising available experimental data on individuals with Parkinsonism. To date, despite promising findings indicating the potential utility of NIBS techniques in Parkinsonism, their integration into clinical routine for diagnostic or therapeutic protocols remains a subject of ongoing investigation and scientific debate. In this context, this paper addresses current unsolved issues and methodological challenges concerning the use of NIBS, focusing on the importance of future research endeavours for maximizing the efficacy and relevance of NIBS strategies for individuals with Parkinsonism.
Neurophysiological Oscillatory Mechanisms Underlying the Effect of Mirror Visual Feedback-Induced Illusion of Hand Movements on Nociception and Cortical Activation
Authors: Rizzo Marco , Petrini Laura , Del Percio Claudio , Arendt-Nielsen Lars , Babiloni Claudio
Published: July 2024

Mirror Visual Feedback (MVF)-induced illusion of hand movements produces beneficial effects in patients with chronic pain. However, neurophysiological mechanisms underlying these effects are poorly known. In this preliminary study, we test the novel hypothesis that such an MVF-induced movement illusion may exert its effects by changing the activity in midline cortical areas associated with pain processing. Electrical stimuli with individually fixed intensity were applied to the left hand of healthy adults to produce painful and non-painful sensations during unilateral right-hand movements with such an MVF illusion and right and bilateral hand movements without MVF. During these events, electroencephalographic (EEG) activity was recorded from 64 scalp electrodes. Event-related desynchronization (ERD) of EEG alpha rhythms (8–12 Hz) indexed the neurophysiological oscillatory mechanisms inducing cortical activation. Compared to the painful sensations, the non-painful sensations were specifically characterized by (1) lower alpha ERD estimated in the cortical midline, angular gyrus, and lateral parietal regions during the experimental condition with MVF and (2) higher alpha ERD estimated in the lateral prefrontal and parietal regions during the control conditions without MVF. These preliminary results suggest that the MVF-induced movement illusion may affect nociception and neurophysiological oscillatory mechanisms, reducing the activation in cortical limbic and default mode regions.
Evaluation of Mild Cognitive Impairment through Perientorhinal/Hippocampal Imaging and Comprehensive Neuropsychological and Psychophysical Assessment
Authors: Invitto Sara , Boscolo-Rizzo Paolo , Spinato Giacomo , Trinchera Giuseppe , Accogli Giuseppe , Ciccarese Vincenzo , Saba Luca , Caggiula Marcella , Barbagallo Gaetano , Pauciulo Alfredo , de Tommaso Marina
Published: July 2024

Mild cognitive impairment (MCI) is a significant concern as it is a risk factor for AD progression, and early detection is vital in order to delay dementia onset and enable potential therapeutic interventions. Olfactory impairment is recognized as a predictive biomarker in neurodegenerative processes. The aims of this study were to explore the degree of entorhinal cortical atrophy (ERICA) and the severity of MCI symptoms; to analyze magnetic resonance imaging (MRI) results for the entorhinal cortex, parahippocampal gyrus, peri entorhinal cortex, and the cerebellar tentorium; and to perform a comprehensive neuropsychological and psychophysical assessment. The main results highlighted that in our sample—multidomain amnesic MCI patients with hyposmic symptomatology—we found that ERICA scores were associated with the severity of anxiety symptomatology. One possible hypothesis to explain this observation is that anxiety may contribute to neurodegenerative processes by inducing chronic stress and inflammation. Future research should consider the longitudinal development of neuropsychological scores, anxiety disorders, and brain atrophy to determine their potential predictive value for MCI progression. These findings suggest the importance of psychological factors in MCI progression and the utility of neuropsychological assessment alongside neuroimaging techniques for early detection and follow-up in MCI patients.
Research on Low-Carbon Building Design Strategies for Folk Dwellings in Hanzhong Based on Single Objective Optimization
Authors: Yu Zhichun , Guo Zhenxing , Ling Zihan , Chen Yuren
Published: July 2024

With the background of rural revitalization, the urgent demand for energy conservation and improved living quality arises alongside the issues of high energy consumption and low comfort in residential buildings. Located in a region with a hot summer and cold winter climate, Hanzhong faces significant energy consumption for heating and cooling throughout the year, considering both winter insulation and summer heat insulation. Based on the energy consumption simulation and analysis of folk dwellings in Hanzhong, this paper employs a single-objective optimization method to explore the optimization of building envelope structures, including the window-to-wall ratio, bay width, number of floors, orientation, and floor height. Additionally, it investigates building layout, spatial organization, regional design methods, and energy acquisition. Through energy consumption simulation and validation of thermal comfort evaluation index PMV-PPD, design strategies such as building scale, layout organization, indoor and outdoor buffer space design, and building material selection are proposed to effectively improve indoor thermal comfort during the winter and summer seasons. This research provides insights and references for the low-carbon design and optimization of residential buildings.
Safety and Feasibility of Neoadjuvant-Modified FOLFIRINOX in Elderly Patients with Pancreatic Cancer
Authors: Shindo Yoshitaro , Ioka Tatsuya , Tokumitsu Yukio , Matsui Hiroto , Nakajima Masao , Kimura Yuta , Watanabe Yusaku , Tomochika Shinobu , Nakagami Yuki , Tsunedomi Ryouichi , Iida Michihisa , Takahashi Hidenori , Nagano Hiroaki
Published: July 2024

The optimal treatment strategy for neoadjuvant chemotherapy in elderly patients with pancreatic cancer (PC) remains unclear. Hence, this study was aimed at evaluating the safety and feasibility of neoadjuvant-modified FOLFIRINOX (mFOLFIRINOX) in elderly patients with PC. We retrospectively collected data from 62 patients who received neoadjuvant mFOLFIRINOX between May 2015 and October 2023 and comparatively analyzed the clinicopathological data and outcomes between the non-elderly group (age: <75 years) and elderly group (age: >75 years). The non-elderly and elderly groups comprised 39 and 23 patients, respectively. Although elevated levels of aspartate aminotransferase (p = 0.0173) and alanine aminotransferase (p = 0.0378) and nausea (p = 0.0177) were more frequent in the elderly group, the incidence of severe adverse events was similar between the groups. Intergroup differences in resection rate (p = 0.3381), postoperative severe complication rates (p = 0.2450), and postoperative hospital stay (p = 0.3496) were not significant. Furthermore, no significant intergroup differences were found in survival in either the whole or the resection cohorts. The perioperative and postoperative outcomes of elderly patients treated with neoadjuvant mFOLFIRINOX were comparable with those of non-elderly patients. Neoadjuvant mFOLFIRINOX should be considered a feasible option for elderly patients with PC.
18F-Fluorodeoxyglucose Positron Emission Tomography-Based Risk Score Model for Prediction of Five-Year Survival Outcome after Curative Resection of Non-Small-Cell Lung Cancer
Authors: Lim Chae Hong , Um Sang-Won , Kim Hong Kwan , Choi Yong Soo , Pyo Hong Ryul , Ahn Myung-Ju , Choi Joon Young
Published: July 2024

The aim of our retrospective study is to develop and assess an imaging-based model utilizing 18F-FDG PET parameters for predicting the five-year survival in non-small-cell lung cancer (NSCLC) patients after curative surgery. A total of 361 NSCLC patients who underwent curative surgery were assigned to the training set (n = 253) and the test set (n = 108). The LASSO regression model was used to construct a PET-based risk score for predicting five-year survival. A hybrid model that combined the PET-based risk score and clinical variables was developed using multivariate logistic regression analysis. The predictive performance was determined by the area under the curve (AUC). The individual features with the best predictive performances were co-occurrence_contrast (AUC = 0.675) and SUL peak (AUC = 0.671). The PET-based risk score was identified as an independent predictor after adjusting for clinical variables (OR 5.231, 95% CI 1.987–6.932; p = 0.009). The hybrid model, which integrated clinical variables, significantly outperformed the PET-based risk score alone in predictive accuracy (AUC = 0.771 vs. 0.696, p = 0.022), a finding that was consistent in the test set. The PET-based risk score, especially when integrated with clinical variables, demonstrates good predictive ability for five-year survival in NSCLC patients following curative surgery.
Progression-Free Survival and Treatment-Free Interval in Head and Neck Cancer with Long-Term Response to Nivolumab: Timing of Active Discontinuation
Authors: Matsuo Mioko , Masuda Muneyuki , Yamauchi Moriyasu , Hashimoto Kazuki , Kogo Ryunosuke , Sato Masanobu , Masuda Shogo , Nakagawa Takashi
Published: July 2024

The optimal timing for actively discontinuing immune checkpoint inhibitor therapy in long-term responders with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC) remains unresolved. We conducted a retrospective study of 246 patients with R/M HNSCC treated with nivolumab to determine the optimal timing to actively discontinue nivolumab therapy. We examined the point at which progression-free survival (PFS) plateaued in all cases. We compared the prognosis of 19 (7.7%) ongoing cases and 227 (92.3%) discontinued cases and analyzed treatment duration and treatment-free interval (TFI). The 6-year overall survival was 11.8% (median, 12.1), and the 6-year PFS was 15.3% (median, 3.0). The PFS curve remained stable for 3 years. The median duration of nivolumab treatment was 2.9 months (range 0.03–81.9): Ongoing group, 41.8 (5.6–81.9); Decision group, 36.8 (4.0–70.1); Toxicity group, 30.6 (2.8–64.8); and progressive disease group, 2.0 (0.03–42.9). TFI in the Decision group was 15.1 months (0.6–61.6) and 30.6 months (2.8–64.8) in the Toxicity group. Long-term responses in R/M HNSCC patients treated with nivolumab are rare but gradually increasing. For this patient group, our best estimate of the optimal time to end treatment is 3 years, as the PFS in this study reached a plateau at that timepoint.
Synthesis and Characterization of Azo-Based Cyclotriphosphazene Compounds: Liquid Crystalline and Dielectric Properties
Authors: Habil Samerah , Jamain Zuhair , Makmud Mohamad Zul Hilmey
Published: July 2024

The study examined the chemical structure of azo-based liquid crystalline compounds that were altered to form a branch of cyclotriphosphazene. Moreover, the research explored the interplay between their mesomorphic and dielectric properties. The structures of the compounds were defined by Fourier transform infrared spectroscopy, nuclear magnetic resonance spectroscopy, and CHN elemental analysis. Only intermediates 2a–e and cyclotriphosphazene compounds 4d–e were mesogenic with smectic A (SmA) and smectic C (SmC) phases, respectively. Intermediate 2d and compound 4d were used as representative samples to determine the type of liquid crystal, which was confirmed through X-ray diffraction (XRD). The calculated d/L ratios for both compounds were 1.69 and 0.76, respectively, indicating that d was approximately equal to L (d ≈ L ≈ 1). This finding suggests that the SmA and SmC phases observed under polarized optical microscope (POM) are arranged in a monolayer. For the dielectric study, only compounds 2d–e and 4d–e were proceeded and compared for dielectric characteristics testing. The dielectric constants and dielectric loss factors of these four compounds were measured over the frequency range of 100 Hz to 0.1 MHz at room temperature. The dielectric constant trend decreased with the increasing frequency. Meanwhile, the dielectric loss showed two types of trends. The first trend was identical to the dielectric constant trend, in which the dielectric loss decreased as the frequency increased. However, in the second trend, the dielectric loss began to rise with the increase in frequency and then began to fall gradually after reaching a certain peak. Meanwhile, compounds 4d and 4e had low dielectric constants and losses due to the effect of hexasubstituted cyclotriphosphazene that had been attached as a core.
Comparison of Metabolic Control in Children and Adolescents Treated with Insulin Pumps
Authors: Lejk Agnieszka , Myśliwiec Karolina , Michalak Arkadiusz , Pernak Barbara , Fendler Wojciech , Myśliwiec Małgorzata
Published: July 2024

Background: While insulin pumps remain the most common form of therapy for youths with type 1 diabetes (T1DM), they differ in the extent to which they utilize data from continuous glucose monitoring (CGM) and automate insulin delivery. Methods: The aim of the study was to compare metabolic control in patients using different models of insulin pumps. This retrospective single-center study randomly sampled 30 patients for each of the following treatments: Medtronic 720G without PLGS (predictive low glucose suspend), Medtronic 640G or 740G with PLGS and Medtronic 780G. In the whole study group, we used CGM systems to assess patients’ metabolic control, and we collected lipid profiles. In three groups of patients, we utilized CGM sensors (Guardian 3, Guardian 4, Libre 2 and Dexcom G6) to measure the following glycemic variability proxy values: time in range (TIR), time below 70 mg/dL (TBR), time above 180 mg/dL (TAR), coefficient of variation (CV) and mean sensor glucose. Results: Medtronic 640G or 740G and 780G users were more likely to achieve a target time in the target range 70–180 mg/dL (≥80%) [Medtronic 720G = 4 users (13.3%) vs. Medtronic 640G/740G = 10 users (33.3%) vs. Medtronic 780G = 13 users (43.3%); p = 0.0357)] or low glucose variability [Medtronic 720G = 9 users (30%) vs. Medtronic 640G/740G = 18 users (60%) vs. Medtronic 780G = 19 users (63.3%); p = 0.0175)]. Conclusions: Any integration between the insulin pump and CGM was associated with better glycemic control. More advanced technologies and artificial intelligence in diabetes help patients maintain better glycemia by eliminating various factors affecting postprandial glycemia.
Identifying Language Development in Children with ADHD: Differential Challenges, Interventions, and Collaborative Strategies
Authors: Katsarou Dimitra V. , Efthymiou Efthymia , Kougioumtzis Georgios A. , Sofologi Maria , Theodoratou Maria
Published: July 2024

Attention Deficit Hyperactivity Disorder (ADHD) significantly influences children’s language acquisition and usage. This theoretical study explores the multifaceted impact of ADHD on language development, specifically focusing on reading and writing challenges. Existing research reveals that approximately 30% of children with ADHD show significant delays in reading proficiency. Additionally, about 40% of these children struggle with phonological processing, which directly impacts their reading and writing skills. Interventions targeting executive function training combined with phonics-based instruction have been shown to significantly improve language outcomes. This study introduces a comprehensive framework connecting these challenges to specific interventions and collaborative strategies, emphasizing the importance of a multi-disciplinary approach. This work provides perspectives on the specific connections between ADHD symptoms and language difficulties, offering detailed potential solutions based on empirical data. Moreover, it features the necessity of adopting integrated intervention strategies to advance academic outcomes and communicative competencies for children with ADHD, providing new understandings into effective educational practices.
Assessment of Adolescents in Child-to-Parent Violence: Invariance, Prevalence, and Reasons
Authors: Burgos-Benavides Luis , Cano-Lozano M. Carmen , Ramírez Andrés , León Samuel P. , Medina-Maldonado Venus , Rodríguez-Díaz Francisco Javier
Published: July 2024

Child-to-parent violence is a form of family violence where the children are the aggressors. Objective: This study first aimed to analyze the psychometric validity of the Child-to-Parent Violence Questionnaire (CPV-Q) among Ecuadorian adolescents. Second, the measurement invariance across the children’s sex was examined. Finally, the prevalence of child-to-parent violence (CPV) was also determined. Methods: A total of 2084 adolescents aged 12 to 18 years participated in this study. The participants were residents of two provinces in southern Ecuador. A higher percentage of participants were women. They lived mostly with their father and mother. The married marital status of the parents was the most frequently reported. Most of the fathers and mothers of the participants completed primary education. The sampling design was probabilistic, with proportional allocation by age and quotas according to the number of inhabitants per province. The sample size was determined by using a finite population formula. All the participants were randomly selected. The CPV-Q was used to assess child-to-parent violence. The items were adapted linguistically and tailored to the Ecuadorian context. Results: The questionnaire demonstrated excellent model fit and adequate reliability. Full measurement invariance was held for all scales except for the reasons subscale pertaining to fathers. Statistically significant differences were observed with respect to the sex of the aggressor, with control/domain behaviors toward both parents and psychological violence toward the mother being more frequent among daughters than sons. Similarly, reactive reasons were more frequent among daughters than sons. Conclusion: This study provides significant psychometric evidence on the CPV-Q in Ecuadorian adolescents along with data on the prevalence of violence against parents.
Development and Evaluation of the Abdominal Pain Knowledge Questionnaire (A-PKQ) for Children and Their Parents
Authors: Neß Verena , Humberg Clarissa , Lucius Franka , Eidt Leandra , Berger Thomas , Claßen Martin , Syring Nils Christian , Berrang Jens , Vietor Christine , Buderus Stephan , Rau Lisa-Marie , Wager Julia
Published: July 2024

Background: Abdominal pain is a common and often debilitating issue for children and adolescents. In many cases, it is not caused by a specific somatic condition but rather emerges from a complex interplay of bio-psycho-social factors, leading to functional abdominal pain (FAP). Given the complex nature of FAP, understanding its origins and how to effectively manage this condition is crucial. Until now, however, no questionnaire exists that targets knowledge in this specific domain. To address this, the Abdominal Pain Knowledge Questionnaire (A-PKQ) was developed. Methods: Two versions were created (one for children and one for parents) and tested in four gastroenterology clinics and one specialized pain clinic in Germany between November 2021 and February 2024. Children between 8 and 17 years of age (N = 128) and their accompanying parents (N = 131) participated in the study. Rasch analysis was used to test the performance of both versions of the questionnaire. Results: The original questionnaires exhibited good model and item fit. Subsequently, both questionnaires were refined to improve usability, resulting in final versions containing 10 items each. These final versions also demonstrated good model and item fit, with items assessing a variety of relevant domains. Conclusion: The A-PKQ is an important contribution to improving assessment in clinical trials focused on pediatric functional abdominal pain.
Assessment and Rehabilitation Intervention of Feeding and Swallowing Skills in Children with Down Syndrome Using the Global Intensive Feeding Therapy (GIFT)
Authors: Franceschetti Silvia , Tofani Marco , Mazzafoglia Serena , Pizza Francesca , Capuano Eleonora , Raponi Massimiliano , Della Bella Gessica , Cerchiari Antonella
Published: July 2024

Background: Children with Down syndrome (DS) experience more difficulties with oral motor skills, including chewing, drinking, and swallowing. The present study attempts to measure the preliminary effectiveness of Global Intensive Feeding Therapy (GIFT) in DS. GIFT is a new rehabilitation program addressing the specific difficulties and needs of each child, focusing on sensory and motor oral abilities. It follows an intensive schedule comprising 15 sessions over 5 consecutive days, with 3 sessions per day. The principles of GIFT are applied with specific objectives for DS. Methods: GIFT was preliminarily implemented among 20 children diagnosed with DS. To measure the efficacy of GIFT, the Karaduman Chewing Performance Scale (KCPS), the International Dysphagia Diet Standardization Initiative (IDDSI), and the Pediatric Screening–Priority Evaluation Dysphagia (PS–PED) were used. Data were analyzed using the Wilcoxon signed-rank test before (T0) and after intervention (T1) and at one-month follow-up (T2). The effect size was also measured for specific outcomes, using Kendall’s W. Results: Our findings revealed that children with DS showed no risk of dysphagia according to the PS–PED (mean score 2.80). Furthermore, statistically significant improvements in chewing performance were observed, as measured by the KCPS (p < 0.01), as well as in texture acceptance and modification, as measured by the IDDSI post-intervention (p < 0.01). For both the KCPS and IDDSI, a large effect size was found (Kendall’s W value > 0.8). Parents/caregivers continued using GIFT at home, and this allowed for a positive outcome at the one-month follow-up. Conclusions: GIFT proved to be effective in the rehabilitation of feeding and swallowing disorders in children with DS, as well as for food acceptance.
Influence of Isothermal Annealing in the 600 to 750 °C Range on the Degradation of SAF 2205 Duplex Stainless Steel
Authors: Burja Jaka , Žužek Borut , Šetina Batič Barbara
Published: July 2024

We studied the effect of isothermal annealing (600–750 °C, 1 to 1000 min) on the microstructure and mechanical properties of SAF 2205 duplex stainless steel. Impact toughness was found to be significantly more affected than hardness by annealing. Annealing at 750 °C for 1000 min resulted in a more than 90% decrease in impact toughness, while hardness only increased by 25%. Tensile strength increased up to 100 MPa, but elongation decreased by more than 50% under the same conditions. Sigma phase formation was minimal at lower temperatures (650 °C and below) but increased significantly at higher temperatures. At 750 °C and 1000 min of annealing, the ferrite content dropped from 50% to 16%. These findings suggest that annealing temperature and time need to be carefully controlled to avoid a reduction in impact toughness and ductility caused by sigma phase precipitation. The harmful effect of sigma phase precipitation on mechanical properties was directly shown.