bluuebunny/crossref_metadata_2025 huggingface dataset:
Deadly Initiations: Characteristics of Hazing Deaths in the United States (1994–2019)
Authors: Perez Nicholas M.
Published: June 2023

On American college campuses, numerous students have died as a result of hazing activities perpetrated in fraternities, sororities, and other student groups. Still, little is known about the common characteristics among these hazing deaths. This study aims to investigate the circumstances surrounding these fatal incidents by examining hazing deaths that occurred at institutions of higher education in the United States from 1994 to 2019. This analysis revealed common characteristics related to the victims, organizations, institutions, incidents, and outcomes of these deaths. The findings support past hazing research, as victims were predominantly males pledging social fraternities. Although hazing deaths were widespread, there was variation among institutional characteristics, region, and size. The perpetrators of these incidents faced legal ramifications, including criminal convictions and civil lawsuits. The recognition of these trends can improve our understanding of the conditions present when dangerous hazing activities occur and the best practices for prevention and response.
Nonintimate Polyvictimization and the Severity of Intimate Partner Violence Experienced by Men
Authors: Lysova Alexandra , Dim Eugene E.
Published: June 2023

There is a dearth of research on the relation of men’s cumulative experiences of nonintimate victimization (polyvictimization) to their victimization in intimate relationships. This study examines the association between nonintimate polyvictimization (including being abused as a child, cyberbullied, stalked, physically assaulted, and experiencing property crime) and the severity of intimate partner violence victimization in men. The sample of 8,784 men in current married/common-law relationships was drawn from a random sample of the 2014 Canadian General Social Survey. About 3% of the men (an estimate of about 265,000 men in Canada) experienced the most severe forms of partner abuse, including the combination of emotional abuse and controlling behaviors, physical violence, and the resulted injuries. Among these severely abused men, about one-third were polyvictims. As expected, a nonintimate polyvictimization predicted the increased severity of male partner abuse victimization, controlling for sociodemographic variables. These findings highlight the importance of preventing nonintimate polyvictimization of men that can help reduce their partner violence victimization.
Tirso Rafael Córdoba y su Manual de literatura hispano-mexicana (1879): entre las letras mexicanas del siglo XIX
Authors: Palma Castro Alejandro , Abadie Maïté Claire
Published: June 2023

¿Cuál fue el legado de Tirso Rafael Córdoba para las letras mexicanas? Para contestar tal pregunta fue necesario reconstruir su biografía a partir de la recopilación y del análisis de sus diversos escritos, así como contextualizar el siglo XIX para comprender mejor el discurso dominante de la época y suponer por qué cayó en el olvido este ilustre autor. Tirso Rafael Córdoba —autor, poeta, historiador, traductor, abogado, soldado, jefe político, educador y sacerdote— fue una personalidad influyente de la segunda mitad del siglo XIX. En el caso de las dos obras de carácter histórico que redactó: El Sitio de Puebla: apuntes para la Historia de México, sacados de documentos oficiales y relaciones con testigos fidedignos (1863) e Historia elemental de México (1881), el autor, en su carácter de historiador y educador, planteó un trabajo que vislumbraba a las siguientes generaciones en un país que buscaba definirse políticamente; este último papel también resalta en su Manual de literatura hispano-mexicana. Las ideas conservadoras y afrancesadas de Córdoba que se perciben desde la lectura detenida de sus obras permiten redimensionar un periodo convulso no solamente en el campo de batalla o en el congreso, sino en el desarrollo de la educación y la cultura. El de Córdoba resultó un modelo relegado y olvidado conforme se afianzó una imagen republicana y liberal de México.
Los clásicos latinos en la poesía de Garcilaso de la Vega: la imitatio como estrategia poética
Authors: Quiñones Melgoza José
Published: June 2023

El presente artículo se propone mostrar, a través de algunos datos biográficos de Garcilaso de la Vega, las circunstancias que lo llevaron a conocer e imitar a los autores clásicos latinos en sus poesías. Entre los que más gozaron de su imitación fueron Virgilio, Horacio y Ovidio. Se especifican cuántas imitaciones de estos autores se encontraron; pero las menciones de dioses y personajes mitológicos son múltiples, lo cual me llevó a pensar, a manera de conclusión, completar alfabéticamente una lista de ellos.
Interpretaciones recientes de la conquista del mundo helenístico por Roma
Authors: Martínez Lacy Ricardo
Published: June 2023

El presente texto tiene como objetivo presentar un balance de distintas aproximaciones a la interpretación de la expansión romana hacia Oriente entre 200 y 30 a. C. Ella se realizó principalmente mediante guerras contra Macedonia, la Confederación Aquea, Siria y Egipto. Para ello se hace un somero análisis de tres propuestas de explicación: la de Arthur Eckstein, llamada realista, la de Paul Burton, constructivista, y la de William Harris, que enfatiza la agresividad de Roma, sin parangón en esa época. Se llega a la conclusión de que, aunque no todas son pro-romanas, ellas están hechas desde el punto de vista de Estados Unidos.
O PIONEIRISMO DAS DANÇAS URBANAS EM RIO GRANDE/RS
Authors: Costa Denise , Lemos Soares Rodrigo , Pinto Finoqueto Leila Cristiane , De Araujo Spotorno Marchand Simone , Silva Oleiro Vithória , Ricarte Teixeira Pollezi do Amaral Daniela , Viacelli Fernandes Daiana , Baldez Furtado Gabriel
Published: June 2023

Esta pesquisa objetiva evidenciar pessoas que contribuíram para o surgimento e o desenvolvimento das Danças Urbanas no município do Rio Grande/RS. Através de estudo de cunho qualitativo, caracterizado como uma pesquisa descritiva, e tendo como instrumento de pesquisa e coleta de informações a entrevista semi-estruturada. Realizamos uma entrevista com dois bailarinos que propuseram as Danças Urbanas sistematizada e com vistas à profissionalização. Identificamos os atravessamentos das Danças Urbanas com os estúdios de dança da cidade, seu processo de profissionalização e a projeção de bailarinos e professores que são reconhecidos como os pioneiros e líderes de grupos de dança importantes no município.
Causes and consequences of large-scale windthrow on the development of fir-beech forests in the Dinaric mountains
Authors: Čater Matjaž , Alagić Ajša , Ferlan Mitja , Jevšenak Jernej , Marinšek Aleksander
Published: June 2023

We investigated several aspects of windthrow that are relevant to our understanding and management of forest ecosystems. As an example, we used an extreme event in December 2017, when the strongest storm in recent history occurred in the Slovenian Dinaric High Karst. We examined influential factors such as soil properties, wind speed, precipitation and ecological consequences for the affected forests. Soil properties were measured around standing and fallen silver fir trees at all three research sites. Tree species composition in the regeneration was observed on plots with chemical and acoustic ungulate deterrents and on control plots without deterrents. Economic estimates of yield loss due to damage were calculated at the national level. A model of the potential threat from windthrow was also developed based on data collected from windthrow events and meteorological data over the past 20 years. Our results indicate that soil depth and mineral fraction depth were similar at sites with and without damaged trees and were not the determining factors for tree toppling. Plots with acoustic deterrents showed the most effective regeneration development, the least decline in silver fir and the greatest increase in noble hardwood seedlings, while plots with chemical deterrents showed the least browsing damage. The estimated economic loss of €16.1 million is 6.6% less than the harvest under normal conditions. The economic loss was relatively low due to the nature of the storm, with the predominant type of damage being uprooted trees with no damaged trunks. The windthrow hazard model revealed that a large number of consecutive events with strong winds in each section weakened the stand, which was subsequently knocked down during the next extreme wind and rainfall event.
Phytosociological description of the dwarf mountain pine shrub community (Amelanchiero ovalis-Pinetum mugo) in the valleys of the Slovenian Alps
Authors: Dakskobler Igor , Cojzer Mateja , Rozman Anrej
Published: June 2023

We have expanded our knowledge of the localities, sites and distribution of the Amelanchiero ovalis-Pinetum mugo association in the Slovenian Alps. Based on phytocenological analyses, the shrub association belonging to the forest vegetation type Alpine mountain pine scrub was divided into two subassociations: peucedanetosum oreoselini and hylocomiadelphetosum triquetri. We also described four variants within the latter association.
Women's agency and childbirth: The effect of transition to motherhood and subsequent births on women's agency in Egypt
Authors: Friedrich Carmen
Published: June 2023

Objective: This study investigates whether women’s agency changes with birth transitions in Egypt and if this change differs by education or rural vs. urban residence.
Background: In the patriarchal context of Egypt, childbearing is almost universal and essential for women’s social position; therefore, it is a potentially relevant factor for agency. However, research on the relationship between childbirth and agency is rare, and little is known about the circumstances under which childbirth might increase agency.
Method: Drawing on longitudinal data from the Egypt Labor Market Panel Survey (2006, 2012, 2018), this study uses fixed effects regression models to estimate the link between birth transitions and women’s agency.
Results: The results show that the transition from having one child to having at least two children is positively associated with women's decision-making power but not their financial autonomy or freedom of movement. This positive relationship is stronger for low-educated women and those living in rural areas than for women with at least an intermediate education and those living in urban areas. Indeed, women living in urban areas have less agency after childbirth.
Conclusion: Overall, the results indicate that birth transitions might affect agency, although not across all dimensions, and that the potential positive impact on agency is substantial only for women who are more restricted to the mother role and live in more patriarchal contexts.
Design of a Smart Community Event Planning Platform
Authors:   , Ackermann Leonie Valentina
Published: June 2023

This master thesis builds upon the project idea ”Raum- und Materiallotse” which is part of Bamberg’s Smart City strategy, and makes suggestions for its implementation. It was investigated which stakeholders are interested in using a Smart Community Event Planning Platform like ”Raum- und Materiallotse” and requirements from the perspective of the expected users were identified via interviews. This project was worked on with Chaudry Hamza Tariq, who was particularly involved in developing a prototype (Smart Events Web Application) based on the user stories distilled from the interviews and proposing a solution to enable access to community-shared rooms through smart locks. Each individual’s contributions to the research are highlighted in the respective chapters. This report provides an in-depth analysis of the Smart Events web app and explores its development and implementation’s technical and practical aspects. It also investigates the potential limitations and challenges of developing a secure access system, including user privacy, security, and scalability issues. Additionally, this master thesis examines how a space search and event planning platform can support the development of Smart Community and makes specific recommendations for its implementation in Bamberg. By exploring the requirements and limitations of such a platform, this thesis contributes to the broader field of access control and secure storage, demonstrating how smart locks and other technologies can be applied to community-based spaces and events and highlighting this approach’s potential benefits and challenges. Furthermore, the research conducted in this master thesis contributes to the ongoing exploration of practices to improve the participation of citizens and non-governmental institutions in Smart Cities and to build sustainable Smart Communities, where individuals, organisations and governing agencies work in partnership to realise a common goal.
Influence of diameter in the stress distribution of extra-short dental implants under axial and oblique load
Authors: Vargas-Moreno Vanessa Felipe , Gomes Rafael Soares , Ribeiro Michele Costa de Oliveira , Freitas Mariana Itaborai Moreira , Del Bel Cury Altair  Antoninha , Marcello-Machado Raissa Micaela
Published: June 2023

Aim: This study evaluated the influence of a wide diameter on extra-short dental implant stress distribution as a retainer for single implant-supported crowns in the atrophic mandible posterior region under axial and oblique load. Methods: Four 3D digital casts of an atrophic mandible, with a single implant-retained crown with a 3:1 crown-to-implant ratio, were created for finite element analysis. The implant diameter used was either 4 mm (regular) or 6 mm (wide), both with 5 mm length. A 200 N axial or 30º oblique load was applied to the mandibular right first molar occlusal surface. The equivalent von Mises stress was recorded for the abutment and implant, minimum principal stress, and maximum shear stress for cortical and cancellous bone. Results: Oblique load increased the stress in all components when compared to axial load. Wide diameter implants showed a decrease of von Mises stress around 40% in both load directions at the implant, and an increase of at least 3.6% at the abutment. Wide diameter implants exhibited better results for cancellous bone in both angulations. However, in the cortical bone, the minimum principal stress was at least 66% greater for wide than regular diameter implants, and the maximum shear stress was more than 100% greater. Conclusion: Extra-short dental implants with wide diameter result in better biomechanical behavior for the implant, but the implications of a potential risk of overloading the cortical bone and bone loss over time, mainly under oblique load, should be investigated.
Apontamento sobre a coleção de livros raros da biblioteca e centro de pesquisas do masp
Authors:   Universidade de São Paulo, Souza Maria Luiza Zanatta de
Published: June 2023

Este artigo pretende apresentar rapidamente alguns apontamentos sobre a valiosa coleção de livros raros pertencentes ao Centro de Pesquisa do MASP – Museu de Arte de São Paulo Assis Chateaubriand. Essa coleção de livros resulta da doação feita pelo casal Pietro Maria Bardi (1900-1999) e sua esposa a arquiteta Lina Bo Bardi (1914-1992), por ocasião do 30º aniversário do museu em 1977, para que pudessem suprir as necessidades dos pesquisadores de Arte e Arquitetura. Todavia, a constituição deste importante acervo, com cerca de 68.000 títulos e aproximadamente 400 livros raros, remonta a um período mais distante, confundindo-se com a própria vida de Bardi – como se pode observar em passagens da biografia do ex-diretor do museu – e a história da própria instituição.
Escritos de artista: do ateliê aos espaços expositivos
Authors:   Universidade de São Paulo, Novaes Sophia de Oliveira
Published: June 2023

Os escritos de artista enquanto objeto de estudo, começam a ser mapeados, organizados e publicados a partir da segunda metade do século XX. As primeiras publicações que coletam de diversos acervos estes textos para sua difusão são: “Art in Theory 1900-19902: An Anthology of Changing Ideas”(1992), organizado por Charles Harrison e Paul Wood; “Theories and Documents of Contemporary Art” (1996), organizada por Kristine Stiles e Peter Selz; e “Escritos de Artista: anos 60/ 70”(2006) de Glória Ferreira e Cecília Cotrim, publicado no Brasil.
Dialética do ver na produção de arte contemporânea: abstração e superfícies imaginadas
Authors:   Universidade Estadual de Campinas, Mendes Talita
Published: June 2023

O objeto deste artigo é a reflexão acerca de modos de abstração no campo da arte, a princípio considerando exemplos de abstração da primeira metade do século XX e de caráter estrangeiro (Figs. 1e 2), e suas potenciais repercussões em produções artísticas de períodos posteriores que se valem de imagens técnicas. O enfoque recai sobre o recurso à estrutura de relações em grade (grids) — que alude à disposição em trama, retícula ou janela — bastante presente no desenvolvimento de obras abstratas de arte moderna.
Imagens de sonhos: exposição Audiovisual Love-Andujar no Masp, 1971
Authors:   Universidade de São Paulo, Camargo Thais Lopes
Published: June 2023

Esta é a primeira exposição realizada pelos fotógrafos George Love e Claudia Andujar3 em colaboração com o Masp e seu diretor, Pietro Maria Bardi. A esta se seguem várias outras iniciativas em torno da prática fotográfica nas quais a participação da dupla é fundamental, entre elas o Laboratório e o Departamento de Fotografia mantidos pelo museu.
Ruptura histórico-literária na obra Lobatiana
Authors: Martelli Márcio Ap , Carneiro Celso Dal Ré
Published: June 2023

Descontextualizar ou contextualizar a obra de Monteiro Lobato faz parte de uma discussão iniciada em 2010, quando a obra Caçadas de Pedrinho, comprada com dinheiro público e distribuída em escolas públicas, foi alvo de represália e levada ao Conselho Nacional de Educação (CNE). A denúncia, feita por Antônio Gomes da Costa Neto, questionara o racismo e preconceito contidos no livro. O fato desencadeou uma onda de protestos, tanto em apoio quanto contrários ao questionamento. Alguns defendem a mera adaptação ou supressão dos termos considerados ofensivos, outros sugerem paratextos que contextualizem o panorama sócio-cultural de época em que a obra foi escrita. Este artigo pondera que a questão deva ser examinada de forma abrangente, levando em conta as opiniões conflitantes e sugestões para superação de impasses, sem deixar de lado a proposta de usar o exemplo de modo comparativo com outras obras seculares, dentro do panorama histórico da evolução do pensamento humano.
Pharmacogenomic screening for agranulocytosis and efficacy with clozapine
Authors: Shad Mujeeb U.
Published: June 2023

Aim: To review genetic biomarkers of agranulocytosis and efficacy with clozapine as a screening tool for the safe and effective use of clozapine. Methods: A PubMed search was performed using PRISMA guidelines for English articles. Separate searches were conducted using “clozapine” AND “agranulocytosis,” and “clozapine” AND (“response” OR efficacy “outcome”) AND “schizophrenia”. Eligible studies reported positive findings with genetic polymorphism(s) associated with clozapine-induced agranulocytosis (CIA) and clozapine’s efficacy. Case reports/series, abstracts, systematic reviews, and meta-analyses were excluded. Negative and genome-wide studies were not formally reviewed but included in the discussion. Results: Twelve out of 572 CIA studies and 32 out of 126 efficacy studies met the eligibility criteria for this review. Most reviewed studies were conducted in small samples of Jewish, Caucasian, and Asian populations using a candidate gene approach. Conclusion: Future research needs to address the limitations of the findings from the reviewed studies to enable a combined genetic screening for CIA and clozapine response to optimize the safe and effective use of clozapine without unnecessarily exposing potential clozapine nonresponders to CIA or neutropenia.
REB’s Statistical Series: Surveys of Industrial Enterprises
Authors: Aukutsionek S. , Batyaeva A. , Demina N. , Egorov A. , Matveev A.
Published: June 2023

Industrial indexes of the Russian Economic Barometer cover a wide range of economic indicators of Russia’s industrial enterprises. The article presents the basic statistical data collected on a monthly, quarterly and semi-annual base by the Russian Economic Barometer through direct surveys of industrial enterprises’ managers. Regular extension of rows allows to consider the dynamics of more than 100 series of indicators, to conduct a comparative analysis of data collected since 1991.
The Relationship between Violence and Participation in Armed Conflict
Authors: McClain Brown Cody
Published: June 2023

This paper systematically and empirically explores participation in the first 10 ‎months of the Croatian Homeland War through theories of collective action. ‎It tests the theory that in the face of indiscriminate violence, individuals will ‎choose to participate in a conflict through joining an armed organization that‎ can provide them with the resources to better survive. I hypothesize that as‎ violence increases in a given area, the number of individuals joining the Croatian‎ military forces will also increase. Using a dataset of daily event data and‎ the number of participants per municipality, I test this hypothesis in a generalized ‎linear model. The results show a significant relationship exists between ‎violent events and increased participation.‎
The Failure of The Nagorno-Karabakh Conflict Resolution
Authors: Boban Davor , Blažević Iva
Published: June 2023

The Nagorno-Karabakh conflict began in 1988 after the regional Supreme ‎Council declared the transfer of the region from the Azerbaijani SSR to the‎ Armenian SSR. The full-scale war started in 1992 after the dissolution of the‎ USSR and ended with the May 1994 armistice. In the following quarter century,‎ a peaceful resolution of the conflict was mediated by OSCE’s Minsk Group in ‎a form of facilitative mediation. The warring sides have never reached a final ‎solution and a new war started in the autumn of 2020. This paper examines how ‎facilitative mediation was conducted by the Minsk Group and why it eventually ‎failed. The conclusion of this paper is that the combination of the weak mandate‎ and the co-chairs’ separate and incongruous interests in the Caucasus resulted in ‎the failure of the conflict resolution in Nagorno-Karabakh.‎
Anisotropic Cosmological Model with SQM in f (R, T) Gravity
Authors: Jokweni Siwaphiwe , Singh Vijay , Beesham Aroonkumar
Published: June 2023

A locally-rotationally-symmetric Bianchi-I model filled with strange quark matter (SQM)
is explored in f(R, T) gravity. We take f(R, T) = R + 2 f(T) = R + 2λT, where R is the Ricci scalar, T
is the trace of energy-momentum tensor and λ is an arbitrary constant. Exact solutions are obtained
by assuming that the expansion scalar is proportional to the shear scalar. This yields a constant value
for the deceleration parameter, q = 2, which corresponds to the decelerated phase of the universe.
The model is found to be physically viable for λ < −1. SQM during early evolution mimics ultra-relativistic radiation whereas at late times, it behaves as dust, quintessence or even the cosmological
constant depending on the value of λ. The effective matter acts as a stiff fluid irrespective of the
matter content and of the f(R, T) terms. The model is shear free at late times but remains anisotropic
throughout the evolution. In the absence of the f(R, T) terms, SQM accelerates the universe. In the
specific case when SQM vanishes at late times, the effect of f(R, T) is to accelerate the universe. The
model admits the possibility that SQM could be an alternative to dark energy.
Cultivable Endophyte Resources in Medicinal Plants and Effects on Hosts
Authors: Wang Yiming , Zhang Yongjing , Cong Hao , Li Changgen , Wu Jiaying , Li Ludan , Jiang Jihong , Cao Xiaoying
Published: June 2023

With the increasing demand for medicinal plants and the increasing shortage of resources, improving the quality and yield of medicinal plants and making more effective use of medicinal plants has become an urgent problem to be solved. In the process of growth and development of medicinal plants, due to the threat of various adversity, there are problems such as nutrient loss and yield decline. Using traditional chemical pesticides to control the stress resistance of plants will cause serious pollution to the environment and even endanger human health. Therefore, it is necessary to find suitable pesticide substitutes from natural ingredients. As an important part of the microecology of medicinal plants, endophytes can promote the growth of medicinal plants, improve the stress resistance of hosts, and promote the accumulation of active components of hosts. Because it has a more positive and direct impact on the host, and can metabolize rich medicinal ingredients, so researchers pay attention to it. This paper reviews the research in recent five years, aiming to provide ideas for improving the quality of medicinal plants, developing more microbial resources, exploring more medicinal natural products, and providing help for the development of the research on medicinal plants and endophytes.
Impact Analysis of Road Infrastructure and Traffic Control on Injury Severity of Single- and Multi-vehicle Crashes
Authors: Tanishita Masayoshi , Sekiguchi Yuta
Published: June 2023

Single and multi-vehicle crashes are a significant issue that causes economic and social costs and has therefore gained attention. This study explored the factors associated with injury severity for both single- and multi-vehicle crashes using over 550,000 crash data points in Japan between 2019 and 2021. We identified the determinants of road infrastructure and traffic control while controlling for driver, vehicle, environmental, and accident characteristics by applying ordered logit and bias-reduced binomial regression models. Our findings are as follows. 1) Traffic control variables did not affect single-vehicle crashes. 2) Guardrails had a higher severity in both single-vehicle crashes and multi-vehicle crashes at intersections. 3) The impact of the centerline differed between intersections and non-intersections for multi-vehicle crashes.  These results of this study provide transportation agencies with important guidance as to the road infrastructure and transport control.
Echocardiography Indices in Urbanized Shor Ethnic Group Representatives With Arterial Hypertension
Authors: Sumin Alexey N , Gomozova Nina S. , Shcheglova Anna V. , Arkhipov Oleg G.
Published: June 2023

The current echocardiography reference values are derived primarily from populations in North America and Europe. It becomes necessary to study ethnically different groups of the population, which often have different living conditions, food habits and lifestyle. The aim of the study was to compare echocardiography indicators in urbanized patients with arterial hypertension of the Shor and non-indigenous ethnic groups living in the Gornaya Shoria region.

The study included patients with arterial hypertension: 58 Shors (20 men and 38 women) and 50 non-indigenous residents (15 men and 35 women) of Gornaya Shoria. All underwent an echocardiographic study with an assessment of the left heart parameters. We assessed the left ventricular hypertrophy (LVH) severity, LV geometry and diastolic function in the ethnic and sex groups.

Shor with hypertension no showed a significant difference in left ventricular dimensions compared to Caucasian. Severe abnormal LVH was associated in the Shors with glucose levels (OR 3.24, 95%CI 1.56-6.7, p=0,001), and in Caucasians with systolic (p=0.021) and diastolic (p=0.011) blood pressure, and heart rate (p=0.033). The Shor men were more likely to have normal LV diastolic function (p=0.029) and LV concentric remodeling (p=0.023), and less often to have normal LV geometry (p=0.015) compared to non-indigenous men.

Thus, this study can be useful in assessing the impact of the development of arterial hypertension, as well as the impact of changing the lifestyle of the Shors when moving to the city from rural areas on ethnic differences in echocardiography.
Investigation of Wound Healing and Anticancer Properties of in vitro Grown Sesame Plant Extract in L929, A549, and MCF-7 Cell Lines and Transcriptomic Analyses of Cas3, Cas9, and BCL-XL Genes in the Sesame Extract Treated Cells
Authors: Yeniocak Sevil , Galatalı Selin , Demir İrem , Uğur Aysel , Saraç Nurdan , Kaya Ergun
Published: June 2023

In addition to its use as a food additive, sesame is also very popular in conventional drugs because of its antifungal, anticancer, analgesic, antioxidant, and antiproliferative, vitamin B and E supplier, serum cholesterol and blood pressure-lowering, wound healing potential. In this study, the cytotoxicity, wound healing, and anticancer (antiproliferation) properties of the ex-tract obtained from in vitro cultures of Sesamum orientale L. cv. "Gökova" were investigated using in L929 fibroblast, MCF-7 breast, and A549 lung epithelial cell lines. In our study, the cisplatin was also used as a control group to compare the anticancer efficacy of our plant extract. The IC50 values obtained from cell treatments were 922.73 µg.ml-1 (plant extract) and 33.09 µg.ml-1 (cispla-tin) for A549 µg.ml-1, 1837.07 µg.ml-1 (plant extract) and 19.27 µg.ml-1 (cisplatin) for MCF-7, and 154.70 µg.ml-1 (plant extract) for L929, respectively. The subcytotoxic doses of the treated plant extract provided the healing of artificially created wounds on L929 fibroblast cell cultures within 48 hours. For the evaluation of the anticancer activity, it was also determined that transcriptomic analyzes of BCL-XL gene, which is negatively correlated with apoptotic pathway, and Cas3 and Cas9 genes, which are positively correlated with apoptotic pathway, showed a statistically sig-nificant increase in A549 and MCF-7 cell lines treated with plant extract or cisplatin. In the light of the results obtained from the present study, it was seen that sesame plant extract may have wound healing potential at decreasing doses and anticancer activity potential at increasing dos-es. The present study can be a useful resource for the development of a drug with wound healing and/or antiproliferative potential, with applications to be made in different cell lines in the future.
The Roles of MicroRNAs in Obesity: Emphasizing Links with Chronic Kidney Disease and Cardiovascular Disorders
Authors: Metzinger-Le Meuth Valérie , Metzinger Laurent
Published: June 2023

Obesity has become a global epidemic, contributing to the development of numerous chronic diseases, including diabetes, chronic kidney disease (CKD) and cardiovascular disorders. MicroRNAs (miRNAs) have emerged as key regulators in various biological processes, including metabolism, inflammation, and tissue remodeling, making them pivotal players in obesity-related pathologies. This review aims to provide comprehensive insights into the roles of miRNAs in obesity, with a particular emphasis on their involvement in the pathogenesis of CKD and cardiovascular disorders. We highlight the involvement of specific miRNAs in adipose tissue development, energy homeostasis, inflammation, and insulin resistance, contributing to the pathogenesis of obesity. Moreover, we explore the impact of miRNAs on renal fibrosis, and inflammation, giving clues on their roles in the development and progression of CKD. Additionally, we discuss the influence of miRNAs on endothelial dysfunction, atherosclerosis, and cardiac remodeling, emphasizing their contribution to obesity-related cardiovascular disorders. Understanding the regulatory functions of miRNAs in these interconnected conditions holds promise for improved diagnosis, prognosis, and therapeutic interventions. Indeed, miRNAs are potential diagnostic biomarkers for obesity-related diseases although challenges remain to be elucidated before their clinical translation. Furthermore, we highlight the emerging strategies that target miRNAs as therapeutic interventions to mitigate the detrimental effects of obesity on kidney and cardiovascular health.
Hospital Readmission of Patients with Diabetic Foot Ulcers: Prevalence, Causes and Outcomes
Authors: Meloni Marco , Andreadi Aikaterini , Ruotolo Valeria , Romano Maria , Bellizzi Ermanno , Giurato Laura , Bellia Alfonso , Uccioli Luigi , Lauro Davide
Published: June 2023

The study aims to evaluate the rate of readmission in patients affected by diabetic foot ulcers (DFUs), causes and the outcomes of patients requiring a new hospitalization. This study is a retrospective observational study including consecutive patients requiring hospitalization since January 2019 to September 2022 due to a DFU. Once they were discharged, patients were regularly followed as outpatients. After 6 months of follow-up, the rate of hospital readmission for a diabetic foot problem was recorded. According to the readmission or not, patients were divided in two groups, readmitted and not readmitted patients respectively. Hence, all patients were followed for six months more and outcomes for the two groups were analyzed and compared. The mean age was 6812yrs, with a prevalence of male (72.6%); the majority of patients were affected by type 2 diabetes (>90%) with a mean diabetes duration of approximately 20yrs. After 6 months of follow-up, 68 (21.9%) patients were readmitted. The main reason of hospital readmission were the presence of critical limb ischaemia (CLI) in the contralateral limb (6.1%), the recurrence of CLI in the previous treated limb (4.5%) and the onset of new infected DFU in the contralateral foot (4.5%). Readmitted patients reported lower rate of healing (51.5vs89.2%,p<0.0001) and higher rate of major amputation (10.3vs4.5%,p=0.04) in comparison to not readmitted patients. CLI and dialysis resulted independent predictors of hospital readmission. Hospital readmission is frequent issue among patients with DFUs, increasing the risk of non-healing and major amputation. CLI resulted the main cause of new hospitalization.
Sustainable Governance of Digital Platform Ecosystem: A Life Cycle Perspective through Multiple Governance Parties
Authors: Han Ying , Xie Lei
Published: June 2023

Today, the digital economy has pursued the required social and economic development, and enterprises can achieve long-term sustainability by relying on the digital platform ecosystem. However, the development of the digital economy and the rapid growth of platform ecosystems have also generated some problems. To study effective digital platform ecosystem governance, this study used the tripartite evolutionary game method and analyzed the changes and effects of platform regulation under different development stages from the perspectives of government, platforms, and enterprises. The results indicate that in the early stages, digital platforms primarily relied on the government’s obligation to regulate. With the digital platform ecosystem’s evolution, the platform organization and settled enterprises’ governance effects gradually appeared, establishing the three common constraints of governance mode. Finally, when the digital platform ecosystem is in its self-renewal period, the government effect is reduced, with the platform itself and settled enterprises taking primary supervisory roles. This study provides reasonable methods for effective platform governance at different stages and enriches the theoretical basis and management practices of platform ecosystems.
First-line Treatment of the Older Patients with CLL: A New Approach in the Chemo-free Era
Authors: Urso Antonio , Cavazzini Francesco , Ballardini Maria Pia , Gambara Silvia , Consolo Sara , Rigolin Gian Matteo , Cuneo Antonio
Published: June 2023

Keywords: chronic lymphocytic leukemia; older patient, Bruton tyrosine kinase, BCL2, cost-effectiveness Bruton tyrosine kinase inhibitors (BTKi) and the BCL2 inhibitor venetoclax, with or without the anti CD20 monoclonal antibody Obinutuzumab, represent the preferred options for the first-line therapy of CLL because they are more effective and may improve quality of life. However, pa-tient’s inclusion criteria were heterogeneous across trials designed for older patients and the identification of CLL-specific parameters identifying unfit patients at risk of developing drug-specific adverse events are required to guide treatment choice. Due to inclusion/exclusion criteria in trials, higher discontinuation rates with BTKi were reported in real-world studies and registry analyses provided useful information on factors predicting for earlier discontinuation in a real-world setting. Though targeted agents were shown to be cost-effective treatments in high-income countries, the out-of-pocket expenses may limit accessibility to these drugs and the overall expenditure for new drugs in CLL is projected to increase substantially posing an issue for sustainability. This being said, the choice of a finite duration treatment based on venetoclax containing regimens or treatment until progression with BTKi is today possible in high- income countries and the therapy choice drivers are represented by coexisting medical conditions rather than age, by patient expectations, logistics and sustainability.
Assessment of the Tumor-Stroma Ratio and Tumor Infiltrating Lymphocytes in Colorectal Cancer: Inter-Observer Agreement Evaluation
Authors: Kazemi Azar , Gharib Masoumeh , Mohammadian Roshan Nema , Traz Jamshid Shirin , Stögbauer Fabian , Eslami Saeid , Schüffler Peter
Published: June 2023

Background: To implement the new marker in clinical practice, reliability assessment, validation, and standardization of utilization must be applied. This study evaluated the reliability of TILs and TSR assessment through conventional microscopy by comparing observers’ estimations. Methods: Intratumoral and tumor-front stromal TILs, and TSR were assessed by three pathologists using 86 HE slides CRC. TSR and TILs were categorized using one and four different proposed cut-off systems, respectively and agreement was assessed using the intraclass coefficient (ICC) and Cohen’s kappa statistics. Pairwise evaluation of agreement was performed using the Fliess Kappa statistic and the concordance rate and it was visualized by Bland-Altman plots. Results: For the evaluation of intratumoral stromal TILs, ICC of 0.505 (95% CI:0.35-0.64) was obtained, Kappa values were in the range of 0.21 to 0.38, and concordance rates in the range of 0.61 to 0.72. For the evaluation of tumor-front TILs, ICC was 0.52 (95% CI:0.32 - 0.67), the overall kappa value ranged from 0.24 to 0.30, and the concordance rate ranged from 0.66 to 0.72. For estimating the TSR, the ICC was 0.48 (95% CI:0.35 - 0.60), the kappa value was 0.49 and the concordance rate was 0.76. Conclusion: The agreement between pathologists in estimating these markers corresponds to poor to the moderate agreement, however, implementing immune scores in daily practice requires more concentration in inter-observer agreements.
Evolution of the Urban Network in the Upper Yellow River Region of China: Enterprise Flow, Network Connections, and Influence Mechanisms —— A Case Study of the Ningxia Urban Agglomeration along the Yellow River
Authors: Zhai Jiagang , Li Mingji , Ming Mengjiao , Yimit Marbiya , Bi Jinlu
Published: June 2023

Given the significant role of the Ningxia Urban Agglomeration along the Yellow River in reshaping the urban network and promoting coordinated development in the upper Yellow River region of China, this paper takes enterprise flow as the explicit manifestation of the regional urban network. Based on the data of registered enterprises from 2005 to 2021, combined with the interlocking network model, social network analysis method, and spatial panel econometric model, this paper interprets the evolution of the regional urban network structure and its influencing mechanisms through the different types of enterprise flow. The results indicate the following: (1) The external network is primarily focused on outflow investments towards North China, East China, and Northwest China. The overall inflow sources form a multi-origin structure dominated by North China and East China. The Jinfeng and Xingqing serve as core hubs for enterprise exports in the external network and destinations for incoming enterprises. However, in the Productive manufacturing connections, a spatial organizational pattern driven by multiple cities has formed. (2) In the internal network, a concentric connection structure centered around the Jinfeng and Xingqing has formed. The Productive service connections are relatively active, while the Productive manufacturing connections are relatively concentrated between the Jinfeng, Xingqing, Ningdong, and Lingwu. However, there is an imbalance in the spatial connections within the urban agglomeration network and an incomplete hierarchical system of network nodes. (3) In the external network, the main feature is the absorption of external elements to foster development momentum. In the internal network, the Jinfeng and Xingqing serve as contact and radiation sources, influencing various nodes. However, their driving capacity is weak. (4) The market demand and coordinated development both demonstrate significant promoting effects on the connections within the external and internal networks. The sluggish adjustment and transformation of regional industrial structure have resulted in a temporary negative inhibitory effect on the development of transformation. The negative impact of urban investment activities and the positive impact of government management are reflected within the internal network. (5) The improvement of urban management and service functions, as well as external borrowing, can promote the connection in different network. However, the borrowing economic activity can have a negative impact in different networks. (6) Industrial agglomeration can promote enterprises connections in different networks and generate significant spatial spillover effects.
Modeling of the Peptide Release During Proteolysis of B-Lactoglobulin by Trypsin
Authors: Vorob’ev Mikhail M.
Published: June 2023

Prospects for predicting the fragmentation of polypeptide chains during their enzymatic hydrolysis using proteolysis models are considered. The opening of the protein substrate during proteolysis and the exposure of its internal peptide bonds for a successful enzymatic attack, the so-called demasking process, were taken into account. The two-step model of proteolysis was used, including the parameters of peptide bond demasking and hydrolysis rate constants for various peptide bonds. Herein, we presented an algorithm for calculating the concentrations of peptide fragments depending on the hydrolysis time or the degree of hydrolysis. The intermediate peptide fragments with two or one internal specific bonds were considered. The fragmentation of β-lactoglobulin (b-LG) with trypsin was predicted, and the calculated concentration curves for peptide fragments were compared with the experimental dependences of concentrations on the degree of hydrolysis. Numerical parameters characterizing the kinetic curves were proposed for the intermediate and final peptide fragments, and they were used to compare the calculated and experimental dependences. The predicted distribution of peptide fragments corresponded to the experimental data on the peptide release during proteolysis of b-LG by trypsin.
Determinants of Purchase Decisions among E-commerce Users: The Significance of Trust, Security, Price, Service Quality, and Risk Perception
Authors: Nursani  , Muhammad Rizqon  , Nur Faiza  , Muhammad Akbar
Published: June 2023

The objective of this study is to determine the influence of Trust, Security, Price, Service Quality, and Risk Perception on Purchase Decisions of E-commerce users through Shopee. This is a quantitative study using a data collection technique of a questionnaire distributed through Google form with a sample size of 100 respondents processed with SPSS version 23. The data analysis uses multiple linear regression. The results of the hypothesis test show that: (1) trust affects purchase decisions; (2) security affects purchase decisions; (3) price does not affect purchasing decisions; (4) service quality does not affect purchasing decisions; and (5) risk perception affects purchase decision of E-commerce consumers through the Shopee website.Trust
A QUANTITATIVE ETHNOBOTANICAL STUDY OF COMMON HERBAL REMEDIES USED AGAINST 13 HUMAN AILMENTS CATERGORIES IN MAURITIUS
Authors: Mahomoodally Fawzi
Published: June 2023

Background and aim: Mauritius is a tropical multicultural island with a long-standing use of herbal remedies. The present ethnobotanical survey was geared towards documenting and preserving local knowledge pertaining to common medicinal plants (MP) used as therapeutic agents in Mauritius.

Methods: Interviews were conducted among local people and herbalists (n=318). Also, 7 quantitative ethnobotanical parameters (variety of use (VU), relative frequency of citation (RFC), informant consensus factor (FIC), fidelity level (FL), index of agreement on remedies (IAR), relative importance (RI) and cultural importance index (CII)) were calculated for MP used.

Results: A total of 87 plants belonging to 45 families were reported to be used in formulating herbal remedies among which 3 endemic plants have been documented. Mentha piperita was found to be the most used plant against gastrointestinal diseases with an RFC index of 0.55. Holy basil (Ocimum tenuiflorum) had the highest RI value (RI=2.00), being cited for 9 different ailments. Therapeutic properties of some herbal remedies reported correlated to some extent with those of previous studies while others have open potential perspectives for further research as their chemistry and pharmacology have not been published.

Conclusion: From the information obtained, it can be suggested that the Mauritian population still relies heavily on MP for their primary health care. Nonetheless, further research is needed to investigate the possible active constituents that could be the basis of an evidence based investigation to discover new drugs.
Reseña de A. Vara López y F. Cuadrado Hidalgo (eds.) (2021). Hacia la recuperación de la memoria. Canon escolar y poesía escrita por mujeres (1927-2020). Córdoba: Universidad de Córdoba-UCO Press.
Authors: Molina Mellado Gema
Published: June 2023

Reseña de A. Vara López y F. Cuadrado Hidalgo (eds.) (2021). Hacia la recuperación de la memoria. Canon escolar y poesía escrita por mujeres (1927-2020). Córdoba: Universidad de Córdoba-UCO Press.
Ta'dib: Character Foundations in the Perspective of Syed Muhammad Naquib Al-Attas
Authors: Ahmad Raden Rizky Fahrial , Ramadhani Reza Aditya , Roibin Roibin , Octaviana Dila Rukmi , Syuhadak Syuhadak
Published: June 2023

The concept of Ta'dib, pioneered by Al-Attas, serves as a suitable guidance in shaping students' characteristics, encompassing not only morality but also individual development rooted in natural and spiritual values. This study aims to explore the concept of Ta'dib proposed by Syed Muhammad Naquib Al-Attas in the formation of students' character. The research adopts a descriptive qualitative approach through a literature review, employing an in-depth philosophical analysis. Primary sources include Al-Attas' books, while secondary sources consist of journal articles, books, and related research materials. Data collection involves gathering Al-Attas' manuscripts, books, and relevant journals, followed by data analysis by scrutinizing the contents of various manuscripts and books to draw conclusive findings. The findings reveal that the integration of earlier principles into character development offers a valuable opportunity to harmonize knowledge acquisition and ethical behavior within students. Consequently, it enables them to contribute to society by performing virtuous acts and exhibiting good conduct, supported by a steadfast foundation of faith.