bluuebunny/crossref_metadata_2025 huggingface dataset:
The effects of anesthesia methods and anesthetics on postoperative delirium in the elderly patients: A systematic review and network meta-analysis
Authors: Zhuang Xuhui , He Yuewen , Liu Yurui , Li Jingjing , Ma Wuhua
Published: November 2022

Study objective

Postoperative delirium (POD) is one of the serious postoperative complications in elderly patients, which is always related to long-term mortality. Anesthesia is often considered a risk factor for POD. This systematic review and network meta-analysis (NMA) aimed to assess the impact of different anesthesia methods and anesthetics on POD.

Measurements

We searched for studies published in PubMed, Embase, Web of Science, Scopus, and Cochrane Library (CENTRAL) from inception to 18 March 2022. RevMan 5.3 and CINeMA 2.0.0 were used to assess the risk of bias and confidence. Data analysis using STATA 17.0 and R 4.1.2. STATA 17.0 was used to calculate the surface under the cumulative ranking curve (SUCRA) and provide network plots with CINeMA 2.0.0. NMA was performed with R 4.1.2 software gemtc packages in RStudio.

Main results

This NMA included 19 RCTs with 5,406 patients. In the pairwise meta-analysis results, only regional anesthesia (RA) with general anesthesia (GA) vs. GA (Log OR: –1.08; 95% CI: –1.54, –0.63) were statistically different in POD incidence. In the NMA results, there was no statistical difference between anesthesia methods, and psoas compartment block (PCB) with bupivacaine was superior to the desflurane, propofol, sevoflurane, and spinal anesthesia with bupivacaine of POD occurrence.

Conclusion

Our study indicated that RA and GA had no significant effect on POD, and there was no difference between anesthesia methods. Pairwise meta-analysis showed that, except for RA with GA vs. GA, the rest of the results were not statistically different. Besides, PCB with bupivacaine may benefit to reduce POD incidence.

Systematic review registration

https://www.crd.york.ac.uk/prospero/dis play_record.php?ID=CRD42022319499, identifier PROSPERO 2022 CRD42022319499.
Tamper-sensitive pre-formed ReRAM-based PUFs: Methods and experimental validation
Authors: Wilson Taylor , Cambou Bertrand
Published: November 2022

In this paper, we present the characterization of pre-formed resistive random access memories to design physical unclonable functions and experimentally validate inherent properties such as tamper sensitivity and a self-destroy mode. The physical unclonable functions were tested for repetitive use, temperature effects, and aging. The variations during successive response generation cycles and drift rates are quantized to explore their reliability. We define tamper-sensitivity as the ability to detect tampering attacks. To establish tamper sensitivity, the cells were characterized for higher current sweeps, and the injected current at which they break down is extracted and analyzed to determine suitable operating ranges. Our experimental results show that at least 91% of the cells can generate keys protected by the scheme, while 22% of the sensing elements are triggered. Finally, the cells were characterized for high Voltage sweeps to be able to destroy the physical unclonable functions on-demand when tampering activity is detected. A fixed Voltage of 1.9 V is enough to destroy the entire array.
Autonomic symptoms in migraine: Results of a prospective longitudinal study
Authors: Ray Jason C. , Cheema Sanjay , Foster Emma , Gunasekera Lakshini , Mehta Dwij , Corcoran Susan J. , Matharu Manjit S. , Hutton Elspeth J.
Published: November 2022

Objective

To assess the prevalence and burden of autonomic symptoms in migraine, and determine the relationship with migraine frequency.

Background

Autonomic symptoms in migraine have been theorized to occur in the setting of inter-ictal sympathetic hypoactivity and hyper-sensitivity. There is limited data prospectively assessing cranial and extra-cranial autonomic symptoms with a validated instrument, or longitudinal data on the relationship between migraine disease activity and autonomic symptoms.

Methods

Patients attending a single tertiary academic center were recruited into a prospective cohort study between September 2020 and June 2022. In addition to standard clinical care, they completed several surveys including the Composite Autonomic Symptom Scale (COMPASS-31) questionnaire, a validated survey of autonomic symptoms.

Results

A total of 43 patients (66.7% female, median age 42, IQR 17) were included in the final analysis. There was a baseline 20 monthly headache days (MHD) (IQR 21.7), and 65.1% of the population had chronic migraine by ICHD-3 criteria. A significantly elevated weighted COMPASS-31 score was reported in 60.5% of respondents (mean 30.3, SD 13.3) at baseline. After 12 months treatment, significant improvements were reported in migraine frequency (median MHD 20–8.7) and disability (median Migraine Disability Assessment Score 67–48), but not in autonomic symptoms (mean score 30.3, SD 11.2).

Conclusion

Autonomic symptoms were frequently reported in patients with migraine. However, they did not correlate with headache frequency or reversion to episodic frequency. Further study is required to elucidate specific approaches and treatments for autonomic symptoms, and further evaluate the underlying pathophysiological mechanisms.
Neural classification maps for distinct word combinations in Broca’s area
Authors: Schell Marianne , Friederici Angela D. , Zaccarella Emiliano
Published: November 2022

Humans are equipped with the remarkable ability to comprehend an infinite number of utterances. Relations between grammatical categories restrict the way words combine into phrases and sentences. How the brain recognizes different word combinations remains largely unknown, although this is a necessary condition for combinatorial unboundedness in language. Here, we used functional magnetic resonance imaging and multivariate pattern analysis to explore whether distinct neural populations of a known language network hub—Broca’s area—are specialized for recognizing distinct simple word combinations. The phrases consisted of a noun (flag) occurring either with a content word, an adjective (green flag), or with a function word, a determiner (that flag). The key result is that the distribution of neural populations classifying word combination in Broca’s area seems sensitive to neuroanatomical subdivisions within this area, irrespective of task. The information patterns for adjective + noun were localized in its anterior part (BA45) whereas those for determiner + noun were localized in its posterior part (BA44). Our findings provide preliminary answers to the fundamental question of how lexical and grammatical category information interact during simple word combination, with the observation that Broca’s area is sensitive to the recognition of categorical relationships during combinatory processing, based on different demands placed on syntactic and semantic information. This supports the hypothesis that the combinatorial power of language consists of some neural computation capturing phrasal differences when processing linguistic input.
Paired pulse transcranial magnetic stimulation in the assessment of biceps voluntary activation in individuals with tetraplegia
Authors: Roumengous Thibault , Thakkar Bhushan , Peterson Carrie L.
Published: November 2022

After spinal cord injury (SCI), motoneuron death occurs at and around the level of injury which induces changes in function and organization throughout the nervous system, including cortical changes. Muscle affected by SCI may consist of both innervated (accessible to voluntary drive) and denervated (inaccessible to voluntary drive) muscle fibers. Voluntary activation measured with transcranial magnetic stimulation (VATMS) can quantify voluntary cortical/subcortical drive to muscle but is limited by technical challenges including suboptimal stimulation of target muscle relative to its antagonist. The motor evoked potential (MEP) in the biceps compared to the triceps (i.e., MEP ratio) may be a key parameter in the measurement of biceps VATMS after SCI. We used paired pulse TMS, which can inhibit or facilitate MEPs, to determine whether the MEP ratio affects VATMS in individuals with tetraplegia. Ten individuals with tetraplegia following cervical SCI and ten non-impaired individuals completed single pulse and paired pulse VATMS protocols. Paired pulse stimulation was delivered at 1.5, 10, and 30 ms inter-stimulus intervals (ISI). In both the SCI and non-impaired groups, the main effect of the stimulation pulse (paired pulse compared to single pulse) on VATMS was not significant in the linear mixed-effects models. In both groups for the stimulation parameters we tested, the MEP ratio was not modulated across all effort levels and did not affect VATMS. Linearity of the voluntary moment and superimposed twitch moment relation was lower in SCI participants compared to non-impaired. Poor linearity in the SCI group limits interpretation of VATMS. Future work is needed to address methodological issues that limit clinical application of VATMS.
The effects of conjugated linoleic acid supplementation on lipid profile in adults: A systematic review and dose–response meta-analysis
Authors: Asbaghi Omid , Ashtary-larky Damoon , Naseri Kaveh , Saadati Saeede , Zamani Mohammad , Rezaei Kelishadi Mahnaz , Nadery Maryam , Doaei Saeid , Haghighat Neda
Published: November 2022

Background

The findings of trials investigating the effect of conjugated linoleic acid (CLA) administration on lipid profile are controversial. This meta-analysis of randomized controlled trials (RCTs) was performed to explore the effects of CLA supplementation on lipid profile.

Methods

Two authors independently searched electronic databases including PubMed, Web of Science, and Scopus until March 2022, in order to find relevant RCTs. The random effects model was used to evaluate the mean and standard deviation.

Results

In total, 56 RCTs with 73 effect sizes met the inclusion criteria and were eligible for the meta-analysis. CLA supplementation significantly alter triglycerides (TG) (WMD: 1.76; 95% CI: −1.65, 5.19), total cholesterols (TC) (WMD: 0.86; 95% CI: −0.42, 2.26), low-density lipoprotein cholesterols (LDL-C) (WMD: 0.49; 95% CI: −0.75, 2.74), apolipoprotein A (WMD: −3.15; 95% CI: −16.12, 9.81), and apolipoprotein B (WMD: −0.73; 95% CI: −9.87, 8.41) concentrations. However, CLA supplementation significantly increased the density lipoprotein cholesterol (HDL-C) (WMD: −0.40; 95% CI: −0.72, −0.07) concentrations.

Conclusion

CLA supplementation significantly improved HDL-C concentrations, however, increased concentrations of TG, TC, LDL-C, apolipoprotein A, and apolipoprotein B.

Systematic review registration

https://www.crd.york.ac.uk/prospero/#recordDetails, identifier: CRD42022331100.
Frailty affects prognosis in patients with colorectal cancer: A systematic review and meta-analysis
Authors: Cai Minghao , Gao Zhongyan , Liao Junyi , Jiang Yuanping , He Yong
Published: November 2022

Background

The prevalence of colorectal cancer has remained high. Most patients have already developed into the middle and advanced stage when they are diagnosed with colorectal cancer, and a small number of them are accompanied by metastasis. In recent years, frailty has been recognized as an important factor affecting the prognosis of colorectal cancer. The aim of this study was to assess the value of frailty on prognosis in patients with colorectal cancer after treatment.

Method

We systematically searched PubMed, Embase, Web Of Science databases up until March2022. A total of 18 studies were retrieved that met the inclusion criteria, including 9 prospective studies and 9 retrospective studies. Frailty screening tools, proportion of frail patients, and outcomes of colorectal cancer patients after treatment were recorded.

Result

18 studies were included with a total of 352,535 participants. Regardless of differences in frailty screening and treatment approaches, outcomes for frailty patients were less favorable in all studies. Compared with the non-frail group, the frail group had higher mortality, more serious complications, more postoperative blood transfusions and delirium, and more support outside the home.

Conclusion

Although there is no uniform standard for frailty screening, assessing the frailty of colorectal cancer patients is of great significance for predicting prognosis of patients after treatment.
Trabectedin and lurbinectedin: Mechanisms of action, clinical impact, and future perspectives in uterine and soft tissue sarcoma, ovarian carcinoma, and endometrial carcinoma
Authors: Gadducci Angiolo , Cosio Stefania
Published: November 2022

The ecteinascidins trabectedin and lurbinectedin are very interesting antineoplastic agents, with a favorable toxicity profile and peculiar mechanisms of action. These drugs form adducts in the minor groove of DNA, which produce single-strand breaks (SSBs) and double-strand breaks (DSBs) and trigger a series of events resulting in cell cycle arrest and apoptosis. Moreover, the ecteinascidins interact with the tumor microenvironment, reduce the number of tumor-associated macrophages, and inhibit the secretion of cytokines and chemokines. Trabectedin has been approved by the Federal Drug Administration (FDA) for patients with unresectable or metastatic liposarcoma or leiomyosarcoma who received a prior anthracycline-based regimen. Moreover, trabectedin in combination with pegylated liposomal doxorubicin (PLD) has been approved in the European Union for the treatment of platinum-sensitive recurrent ovarian cancer. Lurbinectedin has been approved by the FDA for patients with metastatic small cell lung cancer with disease progression on or after platinum-based chemotherapy. The review assesses in vitro and in vivo experimental studies on the antineoplastic effects of both ecteinascidins as well as the clinical trials on the activity of trabectedin in uterine sarcoma and ovarian carcinoma and of lurbinectedin in ovarian carcinoma and endometrial carcinoma.
Purpura with regular shape in an adolescent: Beware of dermatitis artefacta
Authors: Chen Yuhao , Li Lin , Lu Jing
Published: November 2022

Background

Purpura is common in pediatric patients, mostly diagnosed as IgA-related vasculitis (Henoch–Schönlein purpura), idiopathic thrombocytopenic purpura (ITP), and thrombotic thrombocytopenic purpura (TTP). However, in some cases, for example, cases with dermatitis artefacta, it could puzzle a physician or pediatrician for a long time, with great challenges in diagnosis.

Case presentation

We present the case of a 13-year-old boy with recurrent painful purpura on both upper limbs. The physical exam was unremarkable, except for right blepharoptosis and scars from burns. The diagnostic tests were normal. Through repeated communication, the patient was finally diagnosed as having dermatitis artefacta, accompanied by underlying psychological problems.

Conclusions

Before dermatitis artefacta was diagnosed, we spent a lot of money and effort on the diagnosis. Therefore, in order to determine the diagnosis as soon as possible and save on unnecessary medical expenses, we propose a rapid process for the diagnosis of purpura of dermatitis artefacta in children.
Neuropharmacological efficacy of metformin for stroke in rodents: A meta-analysis of preclinical trials
Authors: Fu Wenqiao , Tang Yin , Che Xudong , Tan Jiahe , Ma Yinrui , He Zhaohui
Published: November 2022

Background: Stroke, including ischemic stroke, intracerebral hemorrhage, and subarachnoid hemorrhage (SAH), remains a leading cause of mortality globally. Different stroke subtypes have similar detrimental effects in multiple fields of health. Previous research has shown that metformin plays a neuroprotective role in experimental animal models of stroke; however, a preclinical quantitative analysis on the ability of metformin to treat stroke is still lacking. This meta-analysis evaluates the efficacy of metformin in improving stroke prognosis in rodent models of stroke.

Methods: Relevant preclinical trials were retrieved from PubMed, EMBASE, and the Web of Science. The neurological score (NS), brain water content (BWC), infarct size, rotarod test, TUNEL, neuron quantity, microglia quantity, and p-AMPK levels were compared between a control group and a metformin group using the standardized mean difference (SMD) and corresponding confidence interval (CI). Quality was assessed with SYRCLE’s risk of bias tool.

Results: Fifteen articles published from 2010 to 2022 were included in the meta-analysis. The metformin group had statistically significant differences compared to the control group in the following aspects: NS (SMD −1.45; 95% CI −2.32, −0.58; p = 0.001), BWC (SMD −3.22; 95% CI −4.69, −1.76; p < 0.0001), infarct size (SMD −2.90; 95% CI −3.95, −1.85; p < 0.00001), rotarod test (SMD 2.55; 95% CI 1.87, 3.23; p < 0.00001), TUNEL (SMD -3.63; 95% CI −5.77, −1.48; p = 0.0009), neuron quantity (SMD 3.42; 95% CI 2.51, 4.34; p < 0.00001), microglia quantity (SMD −3.06; 95% CI -4.69, −1.44; p = 0.0002), and p-AMPK levels (SMD 2.92; 95% CI 2.02, 3.82; p < 0.00001). Furthermore, sensitivity analysis and stratified analysis were conducted for heterogeneous outcome indicators.

Conclusion: Overall, metformin treatment improves severe outcomes triggered by stroke. Despite the limitations intrinsic to animal studies, this systematic review may provide a vital reference for future high-quality preclinical trials and clinical use.
Cytological observation and transcriptome analysis reveal dynamic changes of Rhizoctonia solani colonization on leaf sheath and different genes recruited between the resistant and susceptible genotypes in rice
Authors: Liu Sanglin , Wang Tianya , Meng Guoxian , Liu Jiahao , Lu Dibai , Liu Xiangdong , Zeng Yuxiang
Published: November 2022

Sheath blight, caused by Rhizoctonia solani, is a big threat to the global rice production. To characterize the early development of R. solani on rice leaf and leaf sheath, two genotypes, GD66 (a resistant genotype) and Lemont (a susceptible genotype), were observed using four cytological techniques: the whole-mount eosin B-staining confocal laser scanning microscopy (WE-CLSM), stereoscopy, fluorescence microscopy, and plastic semi-thin sectioning after in vitro inoculation. WE-CLSM observation showed that, at 12 h post-inoculation (hpi), the amount of hyphae increased dramatically on leaf and sheath surface, the infection cushions occurred and maintained at a huge number from about 18 to 36 hpi, and then the infection cushions disappeared gradually from about 42 to 72 hpi. Interestingly, R. solani could not only colonize on the abaxial surfaces of leaf sheath but also invade the paraxial side of the leaf sheath, which shows a different behavior from that of leaf. RNA sequencing detected 6,234 differentially expressed genes (DEGs) for Lemont and 7,784 DEGs for GD66 at 24 hpi, and 2,523 DEGs for Lemont and 2,719 DEGs for GD66 at 48 hpi, suggesting that GD66 is recruiting more genes in fighting against the pathogen. Among DEGs, resistant genes, such as OsRLCK5, Xa21, and Pid2, displayed higher expression in the resistant genotype than the susceptible genotype at both 24 and 48 hpi, which were validated by quantitative reverse transcription–PCR. Our results indicated that the resistance phenotype of GD66 was the consequence of recruiting a series of resistance genes involved in different regulatory pathways. WE-CLSM is a powerful technique for uncovering the mechanism of R. solani invading rice and for detecting rice sheath blight–resistant germplasm.
Diagnostic delay of oral squamous cell carcinoma and the fear of diagnosis: A scoping review
Authors: Mauceri Rodolfo , Bazzano Monica , Coppini Martina , Tozzo Pietro , Panzarella Vera , Campisi Giuseppina
Published: November 2022

The mortality rate of patients affected with oral squamous cell carcinoma (OSCC) has been stable in recent decades due to several factors, especially diagnostic delay, which is often associated with a late stage diagnosis and poor prognosis. The aims of this paper were to: analyze diagnostic delay in OSCC and to discuss the various psychological factors of patients with OSCC, with particular attention to the patient’s fear of receiving news regarding their health; and the professional dynamics related to the decision-making processes in cases of suspected OSCC. A preliminary review of literature focusing on OSCC diagnostic delay was performed. Seven articles were included with the diagnostic delay ranging from 45  days to approximately 6  months. Patients’ fears and, to a lesser degree, the concerns of dentists, were found to be still poorly investigated. On the basis of the authors’ professional experience, the development of oral lesions of unknown origin may generate different behaviors in the decision-making processes by patients and clinicians, and fear may play a key role in the distinct steps of this process. It is crucial to increase awareness and inform patients about the onset of OSCC, and contemporaneously encourage experimental studies on patients’ fear and professional behaviors with respect to communication regarding OSCC.
Bilingualism and creativity: Benefits from cognitive inhibition and cognitive flexibility
Authors: Xia Tiansheng , An Yi , Guo Jiayue
Published: November 2022

Bilingualism has been shown to be associated with creativity, but the mechanisms of this association are not very well understood. One possibility is that the skills that bilinguals use in switching back and forth between languages also promote the cognitive processes associated with creativity. We hypothesized that high-proficient Chinese-English bilinguals would show higher convergent and divergent thinking than low-proficient bilinguals, with the differences being mediated by cognitive inhibition and cognitive flexibility, respectively. Chinese university students (N = 54) were classified as high-proficient (n = 27) and low-proficient (n = 27) bilinguals based on their performance on the National English Test for College Students. As expected, group comparisons showed that the high-proficient group had higher scores on the Remote Associates Test (RAT, convergent thinking) and the Torrance Test of Creative Thinking (TTCT, divergent thinking). Also as expected, the association between bilingualism and convergent thinking was mediated by scores on a Stroop task (cognitive inhibition), and the association between bilingualism and divergent thinking was mediated by scores on a More-odd shifting task (cognitive flexibility). These findings suggest that bilingual learning can promote the development of different components of creativity through stronger cognitive inhibition and cognitive flexibility. The results provide empirical evidence for the relationship and mechanism between bilingual learning and creativity.
Grasping the paradoxical nature of wisdom through unconscious integrative complexity
Authors: Kam Christopher , Bellehumeur Christian R.
Published: November 2022

There has been much progress in the scientific study of wisdom on both conceptual and empirical fronts in the past few decades. Despite all the progress being made, there are still gaps that can be filled to provide even more explanatory power and coherence. Although academic discourse on wisdom has included the ability to integrate issues in a complex manner, there is still room for improved theorizing on wisdom’s integrative complexity. Since integrative complexity has both conscious and unconscious dimensions, including the latter in discussions on wisdom will add a valuable aspect to its conceptualization. This article will argue how unconscious integrative complexity is the variable in wisdom’s conceptual equation that involves paradox, which is a well-known sign of wisdom. Explanations contrasting conscious integrative complexity and unconscious integrative complexity in reference to wisdom will be discussed. Then, the Archetypal Test of the Nine Elements will be proposed as a testing instrument to operationalize unconscious integrative complexity. After the conceptualization and operationalization are worked through, we will conclude with a couple examples to illustrate our reflections.
A systematic review on lecturing in contemporary university teaching
Authors: Tronchoni Héctor , Izquierdo Conrad , Anguera M. Teresa
Published: November 2022

Introduction

Articles published in scientific journals, concerning the present and future of the lecture format in university education in the twenty-first century are framed within organizational settings that drive teaching methodologies in line with educational policies. The following two research questions have arisen from articles in which debate the continuity of this teaching modality and propose improvements of a different nature: (1) Is there an interest in renovating the lecture format among the international research community whose remit is university teaching methods? and (2) What improvements to the lecture format do the reviewed articles suggest, within the framework of the communicative matrix of interactive learning?

Method

We have carried out a systematic review guided by the PRISMA approach, emphasizing the interest in methodological conceptual commitment, paying attention to documents published in journals with an impact factor. The search strategy was applied homogeneously in three databases: ERIC, PsycInfo, and Web of Science, following the systematic process of inclusion/exclusion.

Results

Forty-five articles were selected with a range of 0–78 quotations, from different fields of knowledge and five continents; 12 articles are from journals with a JCR impact factor. The journal articles cover communicative (21), cognitive (13) and active-practical perspectives (11); the predominant governing aim of the analyzed improvements is connected with the attendees’ academic performance results (24); the reviewed studies belong mainly to the quantitative paradigm (42). The considerations derived from the results (45) cover formative, technical and/or critical aspects.

Discussion and conclusions

Whilst positively valuing all these efforts promoted by the European Higher Education Area, we have also verified the lack of contributions in line with our concerns that embrace the need to develop an in-depth conceptualization, supported by a methodology that is sensitive to the complexity of the oral communication format between an expert actor and non-specialized actors who wish to connect and collaborate with the expert in the production of knowledge.
Rasch validation of the Arabic version of the beach center family quality of life scale (BCFQOL-AR)
Authors: Alnahdi Ghaleb Hamad
Published: November 2022

Aim

This study aimed to examine the dimensionality of the BCFQOL-AR using Rasch analysis.

Method

The sample consisted of 320 families having a member with intellectual or developmental disabilities. Rasch analysis was used to validate the dimensionality of the scale. The participants were from Riyadh, Saudi Arabia.

Results

The BCFQOL-AR 25-item scale was multidimensional. Rasch analyses support the unidimensionality of the five subscales. There were no indicators of differential item function for any of the items, regardless of sex or age.

Conclusion

The BCFQOL-AR is a multidimensional scale that measures families with members who are satisfied with their quality of life. Therefore, obtaining a total score at the subscale level is supported and showed that each of the five subscales of the BCFQOL can be used alone. This study partially supports the practices used with other versions of the scale, by providing the statistical base, where means were used at the subscale level in different countries.
Assessment of social justice dimensions in young adults: The contribution of the belief in a just world and social dominance orientation upon its rising
Authors: Etchezahar Edgardo , Barreiro Alicia , Albalá Genol Miguel Ángel , Maldonado Rico Antonio Francisco
Published: November 2022

The aim of the study was to analyze the psychometric properties of the Social Justice Scale, composed by Representation, Recognition, and Redistribution dimensions. Likewise, the contribution of social dominance and the belief in a just world in each dimension were analyzed. A total of 471 young adults residing in Madrid participated in the online preliminary study, with an age range of 18–42 years with different genders (74.1% defined themselves as female). The main results indicated adequate psychometric properties for Social Justice Scale through its three dimensions. In addition, we observed that both social dominance and belief in a just world might be psychosocial variables that modulate the levels of social justice. The main findings of the research and need for replication in future studies are discussed.
Does time heal all wounds? How is children’s exposure to intimate partner violence related to their current internalizing symptoms?
Authors: Ronzón-Tirado Román , Redondo Natalia , Zamarrón María D. , Muñoz Rivas Marina J.
Published: November 2022

The effects of time and the longitudinal course of the children’s internalizing symptoms following Intimate Partner Violence Exposure (IPVE) are still of great interest today. This study aimed to analyze the effect of the frequency of IPVE, adverse experiences after the cessation of the IPVE and the time elapsed since the termination of the violent relation on the prevalence of anxiety and depression among children. Participants were 107 children and their mothers who had been victims of IPV and had existing judicial protection and restraining orders. Hierarchical logistic regression models were estimated to analyze children’s adjustment, considering the effect of the time elapsed since the termination, frequency of IPVE, experiences of revictimization, maternal pathology, and anxious anticipation of the mother at the prospect of future harm. Exposure to multiple events of violence at the hands of multiple ex-partners and higher scores in the mother’s anxious anticipation were significant predictors of children’s pathological depression and anxiety. Our results emphasize the need for early psychological evaluation of women and children’s victims of IPV to provide timely interventions that avoid symptoms from becoming chronic. Strategies to bring support and emotional security to the victims after the end of the violent relationship are desirable.
Use of compulsory community treatment in mental healthcare: An integrative review of stakeholders’ opinions
Authors: de Waardt Dieuwertje Anna , van Melle Anne Laura , Widdershoven Guy Antoine Marie , Bramer Wichor Matthijs , van der Heijden Franciscus Martinus Machiel Adrianus , Rugkåsa Jorun , Mulder Cornelis Lambert
Published: November 2022

Background

Multiple studies have examined the effects of compulsory community treatment (CCT), amongst them there were three randomized controlled trials (RCT). Overall, they do not find that CCT affects clinical outcomes or reduces the number or duration of hospital admissions more than voluntary care does. Despite these negative findings, in many countries CCT is still used. One of the reasons may be that stakeholders favor a mental health system including CCT.

Aim

This integrative review investigated the opinions of stakeholders (patients, significant others, mental health workers, and policy makers) about the use of CCT.

Methods

We performed an integrative review; to include all qualitative and quantitative manuscripts on the views of patients, significant others, clinicians and policy makers regarding the use of CCT, we searched MEDLINE, EMBASE, PsycINFO, CINAHL, Web of Science Core Collection, Cochrane CENTRAL Register of Controlled Trials (via Wiley), and Google Scholar.

Results

We found 142 studies investigating the opinion of stakeholders (patients, significant others, and mental health workers) of which 55 were included. Of these 55 studies, 29 included opinions of patients, 14 included significant others, and 31 included mental health care workers. We found no studies that included policy makers. The majority in two of the three stakeholder groups (relatives and mental health workers) seemed to support a system that used CCT. Patients were more hesitant, but they generally preferred CCT over admission. All stakeholder groups expressed ambivalence. Their opinions did not differ clearly between those who did and did not have experience with CCT. Advantages mentioned most regarded accessibility of care and a way to remain in contact with patients, especially during times of crisis or deterioration. The most mentioned disadvantage by all stakeholder groups was that CCT restricted autonomy and was coercive. Other disadvantages mentioned were that CCT was stigmatizing and that it focused too much on medication.

Conclusion

Stakeholders had mixed opinions regarding CCT. While a majority seemed to support the use of CCT, they also had concerns, especially regarding the restrictions CCT imposed on patients’ freedom and autonomy, stigmatization, and the focus on medication.
Differences in health behavior and nutrient intake status between diabetes-aware and unaware Korean adults based on the Korea national health and nutrition examination survey 2016–18 data: A cross-sectional study
Authors: Sharma Anshul , Lulu Chen , Song Kee-Ho , Lee Hae-Jeung
Published: November 2022

Background

The aim of this study was to investigate the nutritional intakes and treatment regimens of Korean patients with type 2 diabetes who were aware of their condition.

Methods

Participants (n = 16582) aged ≥ 19 years from the 2016–18 National Health and Nutrition Survey were divided into diabetes-aware and unaware groups and the variables were compared.

Results

Among 1,906 (11.5%) diabetic adults, 1,433 (75.2%) were aware of their condition; 130 (9.1%) had nutrition education, and 1,340 (93.5%) were in the diabetes-aware treatment group. The diabetes-aware group had higher average age (P < 0.0001) and lower average BMI (P = 0.0015) than the unaware group. Intake of total fat (P = 0.0034), saturated fatty acids (P = 0.0021), riboflavin (P = 0.0035) and niacin (P = 0.0228) was significantly higher in the unaware group than in the diabetes-aware group, after adjusting energy intake for age and sex. Current smoking (P = 0.0046) and heavy drinking (P < 0.0001) rates were higher in the unaware group, whereas fiber intake (P = 0.0054) was lower in the unaware group. Higher levels of glycated hemoglobin were found in the group treated for diabetes (7.2%) than in the no-treatment (6.8%) group (P = 0.0048). Diabetes control was significantly better in the high income group.

Conclusions

There is a need to strengthen nutritional education to prevent diabetes and improve the health status of diabetic patients in Korea.
Cost-effectiveness analysis of sugemalimab vs. placebo, in combination with chemotherapy, for treatment of first-line metastatic NSCLC in China
Authors: Li Wei , Wan Li
Published: November 2022

Objective

The purpose of this study was to estimate the cost-effectiveness of sugemalimab plus chemotherapy (SC) vs. placebo plus chemotherapy (PC), as the first-line treatment for patients with non-small cell lung cancer (NSCLC) in China.

Material and methods

A three-state Markov model with a cycle of 3 weeks was built to assess the incremental cost-effectiveness ratio (ICER) of SC vs. PC as first-line treatment for patients with NSCLC over a 10-year horizon from Chinese health care perspective. Time-dependency transition probability and safety data were derived from a multicenter, randomized, double-blind, phase 3 clinical trial performed in China (GEMSTONE-302). Primary model outcomes included the costs in US dollars and health outcomes in quality-adjusted life-years (QALYs) and the ICER under a willingness-to-pay (WTP) threshold of $37,663/QALYs. Deterministic, scenario and probabilistic sensitivity analysis were employed to investigate the robustness of model outcomes.

Results

In base-case analysis, compared with PC, first-line SC for intention-to-treat (ITT) population gained an additional 0.57 QALYs with an incremental cost of $62,404.15, resulting in an ICER of $109,480.97/QALYs gained. When a patient assistance program (PAP) was available, the ICER decreased to $52,327.02/QALYs. In subgroup analysis, the ICER values were above the WTP threshold with or without PAP. Sensitivity analysis results suggested that the model outcomes were reliable.

Conclusion

From the perspective of Chinese healthcare system, the SC was not cost-effective in comparison to PC as first-line treatment for NSCLC, regardless of PD-L1 tumor expression level and pathological subtype.
How Do Organisms Affect and Respond to Climate Change?
Authors: Asatryan Gayane , Harbott Marie , Todorović Sara , Kaplan Jed O. , Lazarus David , Lee Carol Eunmi , Parmesan Camille , Renaudie Johan , Thomas Helmuth , Wu Henry C. , Richards Christina L.
Published: November 2022

Life on Earth is diverse at many levels, meaning there is a lot of variety within species and there are many different kinds of species. This biodiversity provides many of the resources that humans need and enhances our quality of life. All of Earth’s organisms are affected by Earth’s climate, but they also influence Earth’s climate. In this article, we show how research on plants, animals, and microbes helps us better understand how living things can both impact and respond to climate change. This research also gives us insight into what the future might be like for life on Earth. Such knowledge will help us to protect our planet—and the living things on it—from the harmful effects of future climate change.
Epidemiological and therapeutic studies on sheep lice in Sayint district, South Wollo Zone, Northeast Ethiopia
Authors: Legesse Simegn , Hailemelekot Mussie , Tamrat Habtamu , Alemu Yeshwas F.
Published: November 2022

An epidemiological (cross-sectional) and therapeutic (randomized controlled field trial) study was conducted on sheep lice in Sayint district, South Wollo, Northeast Ethiopia. The aim of the study was to (i) quantify the magnitude of sheep lice burden and the prevailing lice species, (ii) identify and quantify risk factors affecting lice infestation in sheep, and (iii) evaluate the efficacy of commonly used acaricides (diazinon and ivermectin) against sheep lice infestation. A total of 232 randomly selected sheep, 15 naturally infested sheep, and 80 viable Bovicola ovis lice were used for epidemiological, in vivo, and in vitro based therapeutic studies, respectively. Three naturally infested treatment groups each with five sheep (Group I—treated with diazinon, Group II—treated with ivermectin, and Group III—untreated/control) were used for in vivo therapeutic study. Lice count for the corresponding treatment groups was conducted on weekly basis using clinical and parasitological examinations. We used logistic regression to quantify the association between different putative risk factors and lice infestation, and the independent t-test and one-way ANOVA to compare the within and between treatment group mean lice count variations. The overall prevalence of sheep lice in the study area was 48.3%, where Bovicola ovis (83%) was the dominant lice species. Hair length, body condition, agroecology, and season were significantly (P < 0.05) associated with sheep lice infestation. Analysis of variance revealed that mean lice count significantly (P < 0.05) varies between treatment groups. A significant (P < 0.05) low mean lice cunt was recorded in diazinon- and ivermectin-treated groups when compared to untreated group. The in vivo efficacy of ivermectin (81%) was lower than diazinon (99%) when compared to the efficacy standard limit (98–100%). However, no significant mean lice count variation was recorded between the two groups. In vivo (99%) and in vitro (95%) assay evidence revealed that diazinon was highly effective for the treatment of sheep lice. According to this study, it can be concluded that the magnitude of sheep lice burden in Sayint district was found to be high and this could have a potential negative impact on sheep productivity and health performances. Thus, applying an appropriate intervention measure including the right choice of effective acaricides could help to control sheep lice in the study area.
Diagnostic utility of LDH measurement for determining the etiology of modified transudate pleural effusion in cats
Authors: Mon Hla Hsu , Hunprasit Vachira , Siripoonsup Jedsada , Rungsipipat Anudep , Radtanakatikanon Araya
Published: November 2022

Fluid analysis is an initial approach for determining the underlying causes of body cavity effusions. Modified transudate is commonly diagnosed in pleural effusion in cats, however, it provides limited diagnostic information. Aims of this study were to investigate common etiologies causing different pleural fluid types and to evaluate the usefulness of lactate dehydrogenase (LDH) for differentiating the etiology in modified transudates in cats. Pleural effusion samples from 122 cats were analyzed and classified into three types: transudate, modified transudate, and exudate. Causes of pleural effusion were classified into four conditions: cardiac disease, neoplasia, feline infectious peritonitis (FIP), and pyothorax. The relationship of underlying etiology and fluid types was described. The LDH levels in pleural fluid and plasma were compared between the causes in the samples classified as modified transudate. The fluid analysis of pleural effusion showed that modified transudate was the most common fluid type (44.2%). Neoplasia was predominantly diagnosed (38.5%) as the etiology of pleural effusion. There was no significant correlation between pleural fluid and plasma LDH level in any type of pleural fluid, suggesting that pleural fluid LDH does not appear to be affected by plasma LDH. The occurrence of modified transudate was not associated to its etiologies, however, the LDH level in modified transudates showed significant differences between etiologic groups. The LDH level in modified transudate was excellent in separating cardiac from non-cardiac diseases with a cut-off value of <535 U/L and separating FIP from non-FIP diseases with a cut-off value of >641 U/L. Based on the current findings, pleural fluid LDH can be a useful adjunctive marker for differentiating some causes of modified transudate pleural effusion and should be added in the routine diagnostic work-up of feline patients with pleural effusions.
Reducing the Computational Cost for Artificial Intelligence-Based Battery State-of-Health Estimation in Charging Events
Authors: Falai Alessandro , Giuliacci Tiziano Alberto , Misul Daniela Anna , Anselma Pier Giuseppe
Published: November 2022

Powertrain electrification is bound to pave the way for the decarbonization process and pollutant emission reduction of the automotive sector, and strong attention should hence be devoted to the electrical energy storage system. Within such a framework, the lithium-ion battery plays a key role in the energy scenario, and the reduction of lifetime due to the cell degradation during its usage is bound to be a topical challenge. The aim of this work is to estimate the state of health (SOH) of lithium-ion battery cells with satisfactory accuracy and low computational cost. This would allow the battery management system (BMS) to guarantee optimal operation and extended cell lifetime. Artificial intelligence (AI) algorithms proved to be a promising data-driven modelling technique for the cell SOH prediction due to their great suitability and low computational demand. An accurate on-board SOH estimation is achieved through the identification of an optimal SOC window within the cell charging process. Several Bi-LSTM networks have been trained through a random-search algorithm exploiting constant current constant voltage (CCCV) test protocol data. Different analyses have been performed and evaluated as a trade-off between prediction performance (in terms of RMSE and customized accuracy) and computational burden (in terms of memory usage and elapsing time). Results reveal that the battery state of health can be predicted by a single-layer Bi-LSTM network with an error of 0.4% while just monitoring 40% of the entire charging process related to 60–100% SOC window, corresponding to the constant-voltage (CV) phase. Finally, results show that the amount of memory used for data logging and processing time has been cut by a factor of approximately 2.3.
Epigenetic Reprogramming of Kaposi’s Sarcoma-Associated Herpesvirus during Hypoxic Reactivation
Authors: Singh Rajnish Kumar , Bose Dipayan , Robertson Erle S.
Published: November 2022

The biphasic life cycle (latent and lytic) of Kaposi’s sarcoma-associated Herpesvirus (KSHV) is regulated by epigenetic modification of its genome and its associated histone proteins. The temporal events driving epigenetic reprogramming of the KSHV genome on initial infection to establish latency has been well studied, but the reversal of these epigenetic changes during lytic replication, especially under physiological conditions such as hypoxia, has not been explored. In this study, we investigated epigenetic reprogramming of the KSHV genome during hypoxic reactivation. Hypoxia induced extensive enrichment of both transcriptional activators and repressors on the KSHV genome through H3K4Me3, H3K9Me3, and H3K27Me3, as well as histone acetylation (H3Ac) modifications. In contrast to uniform quantitative enrichment with modified histones, a distinct pattern of RTA and LANA enrichment was observed on the KSHV genome. The enrichment of modified histone proteins was due to their overall higher expression levels, which was exclusively seen in KSHV-positive cells. Multiple KSHV-encoded factors such as LANA, RTA, and vGPCR are involved in the upregulation of these modified histones. Analysis of ChIP-sequencing for the initiator DNA polymerase (DNAPol1α) combined with single molecule analysis of replicated DNA (SMARD) demonstrated the involvement of specific KSHV genomic regions that initiate replication in hypoxia.
Meta-Analysis of Repeat Hepatectomy versus Radiofrequency Ablation for Recurrence of Hepatocellular Carcinoma
Authors: Machairas Nikolaos , Papaconstantinou Dimitrios , Dorovinis Panagiotis , Tsilimigras Diamantis I. , Keramida Myrto D. , Kykalos Stylianos , Schizas Dimitrios , Pawlik Timothy M.
Published: November 2022

Hepatocellular carcinoma (HCC) is the most common primary hepatic malignancy and a leading cause of cancer-related death in both the developed and developing world. Recurrent HCC (rHCC) develops in a significant proportion of patients even following curative-intent resection. In the absence of a structured treatment algorithm, a number of treatment options including repeat hepatectomy (RH) and radiofrequency ablation (RFA) have been utilized in select patients with rHCC. The aim of this systematic review and meta-analysis was to compare short- and long-term outcomes of patients undergoing RHR versus RFA for rHCC. Four electronic databases were screened until September 2022. A total of 17 studies were included in the meta-analysis. Overall and disease-free survival were comparable among the two groups. Patients undergoing RH were less likely to develop a second recurrence (RR 0.89, 95% C.I. 0.81 to 0.98, p = 0.02). Overall and major morbidity were significantly increased in the RH group (RR 3.01, 95% C.I. 1.98 to 4.56, p < 0.001 and RR 3.65, 95% C.I. 2.07 to 6.43, p < 0.001, respectively), while mortality was similar between RFA and RH. The data demonstrated that RFA is a safe and efficient alternative to RH for selected patients with rHCC. Nevertheless, despite higher morbidity associated with RH, repeat resection remains the preferred treatment option whenever feasible, as it allows for better local disease control.