bluuebunny/crossref_metadata_2025 huggingface dataset:
CD11c+ dendritic cells PlexinD1 deficiency exacerbates airway hyperresponsiveness, IgE and mucus production in a mouse model of allergic asthma
Authors: Shan Lianyu , Matloubi Mojdeh , Okwor Ifeoma , Kung Sam , Almiski Mohamed Sadek , Basu Sujata , Halayko Andrew , Koussih Latifa , Gounni Abdelilah S.
Published: August 2024

Dendritic cells (DCs) are pivotal in regulating allergic asthma. Our research has shown that the absence of Sema3E worsens asthma symptoms in acute and chronic asthma models. However, the specific role of PlexinD1 in these processes, particularly in DCs, remains unclear. This study investigates the role of PlexinD1 in CD11c+ DCs using a house dust mite (HDM) model of asthma. We generated CD11c+ DC-specific PlexinD1 knockout (CD11cPLXND1 KO) mice and subjected them, alongside wild-type controls (PLXND1fl/fl), to an HDM allergen protocol. Airway hyperresponsiveness (AHR) was measured using FlexiVent, and immune cell populations were analyzed via flow cytometry. Cytokine levels and immunoglobulin concentrations were assessed using mesoscale and ELISA, while collagen deposition and mucus production were examined through Sirius-red and periodic acid Schiff (PAS) staining respectively. Our results indicate that CD11cPLXND1 KO mice exhibit significantly exacerbated AHR, characterized by increased airway resistance and tissue elastance. Enhanced mucus production and collagen gene expression were observed in these mice compared to wild-type counterparts. Flow cytometry revealed higher CD11c+ MHCIIhigh CD11b+ cell recruitment into the lungs, and elevated total and HDM-specific serum IgE levels in CD11cPLXND1 KO mice. Mechanistically, co-cultures of B cells with DCs from CD11cPLXND1 KO mice showed significantly increased IgE production compared to wild-type mice.These findings highlight the critical regulatory role of the plexinD1 signaling pathway in CD11c+ DCs in modulating asthma features.
Curating the Unseen: Sound, Space and Attention in the Séance and the Smart Home
Authors: Borkowski Alex
Published: August 2024

This article discusses the sonic and spatial configurations of the Spiritualist séance as a speculative antecedent to the presence of disembodied voices, such as Amazon’s Alexa, in contemporary homes. I examine archival notes, photographs and audio recordings in order to unpack how séances curated domestic spaces in order to display and interrogate unseen agents. Further, I consider the presentation of the sound installation The Dark Age of Connectionism: Captivity (2017) by Wesley Goatley at IMPAKT festival, curated by the curatorial collective Haunted Machines, as a case study that demonstrates how the exhibition framework articulated in the séance room might be applied as critical strategy in gallery spaces.
GC-MS/MS-Based Detection and Quantification of Methamphetamine and Mephedrone in Biological Matrices using Modified dSPE Method
Authors: Jangra Anjali , Sarin R.K. , Nayak Biswa Prakash , Khajuria Himanshu
Published: August 2024

This research presents a technique combining gas chromatography and tandem mass spectrometry (GC-MS/MS) with a modified dispersive solid phase extraction (D-SPE) method for identifying and quantifying methamphetamine (MTPn) and mephedrone (MPDn) in biological samples. These amphetamine-category new psychoactive substances are increasingly popular among young individuals, making their detection crucial. The method involves a clean-up procedure integrated with GC-MS/MS technology, allowing simultaneous detection of both drugs. Operating the analytical column at 40 ºC with sample concentrations ranging from 5 to 200 ng/mL, the study determined the limit of detection (7.326-20.213 ng/mL) and the limit of quantification (22.2-60.25 ng/mL). The modified dSPE method’s efficacy was compared to other extraction techniques, highlighting the sensitivity, accuracy and precision of the GC-MS/MS method. These findings have significant implications for forensic and clinical applications in detecting and quantifying methamphetamine and mephedrone.
Comparison of Fabrication Process of Poly(methyl methacrylate) (PMMA) Membranes and their Amine Functionalization Studies for Application in Biosensing
Authors: Sehgal S. , Nayak B.P. , Haque I. , Tiwari R.
Published: August 2024

The comparison of the fabrication process of poly(methyl methacrylate) (PMMA) membranes and their functionalization on the basis of various characterization studies to produce a robust, stable and adherent amine functionalized surface for application in biosensing was attempted in present work. PMMA membrane fabricated using solution casting and compression moulding were characterized morphologically using electron microscopy (SEM) and functionalized with O2, N2 and He plasma at the same discharge conditions followed by deposition of (3-aminopropyl)triethoxysilane (3-APTES), an alkoxysilane, on the membranes in three different concentrations (5%, 10% and 15%). Using contact angle measurements, changes within the surface hydrophilicity were determined for pristine PMMA, plasma treated and plasma followed by 3-APTES treated PMMA membranes while amine functionalization was confirmed by Fourier transform infrared spectroscopy (FTIR). Further, the density of reactive amine groups on the membrane was estimated using fluorescent reagent in confocal microscope, which revealed that although all the plasma and 3-APTES treatments resulted in functionalization of PMMA membranes, however treatment with He plasma and 10% APTES displayed 10 to 15 times more reactive amine groups on PMMA membranes in comparison to the other plasma and 3-APTES treatments. Moreover, among the two fabricated membranes, it was found that solution casted PMMA membrane yielded twice more reactive amine groups than the compression moulded membrane. The results suggested the stability and ability of He plasma and 10% APTES treated PMMA membrane to immobilize DNA and other biomolecules efficiently and thereby can act as biosensing platform.
Exploring Indolyl Triazoles: Synthesis, Computational Profiling and Antimicrobial Assessment
Authors: Birudala Geetha , Dighe Rajendra Dnyandeo , Kasimedu Saravanakumar , Pulipati Sowjanya , Veluru Hari , Gandupally Naveenkumar , Singh Gurinderdeep
Published: August 2024

In this work, a series of new indolyl-triazole compounds (IT1-8) were synthesized, characterized and evaluated for their in vitro antimicrobial activities. The synthesis involved reactions of indole acetic acid and hydrazine, followed by cyclization with various reagents, yielding triazole compounds elucidated by TLC, IR, NMR, and mass spectral data. Computational profiling using PASS and Molinspiration indicated potential antitubercular and anticancer activities, with compounds IT1 and IT2 showing high bioactivity scores. ProTox 3.0 analysis identified compound IT5 as the safest compound regarding toxicity. The synthesized indolyl-triazoles exhibited significant antimicrobial activity, especially against Mycobacterium tuberculosis and various bacterial strains. The experimental assessments revealed unexpected antibacterial activities, particularly in compounds IT5 and IT6, highlighting the significance of halogenated phenyl rings and indolyl moieties in their efficacy. The study underscores the potential of indolyl-triazoles as antimicrobial agents and the role of computational tools in drug discovery, while also noting the discrepancy between in silico predictions and experimental results, suggesting the need for further exploration of structure-activity relationships (SAR).
Growth curve pea in different seasons as a function of accumulated thermal sum
Authors: Tartaglia Francieli de Lima , Dal'Col Lúcio Alessandro , Inês Diel Maria , Lambrecht Darlei Michalski , Luís Tischler André , Sgarbossa Jaqueline
Published: August 2024

The objective of this study was to determine the performance of peas grown in the field, in three growing seasons, by adjusting the nonlinear logistic model and its critical points. Uniformity trials were conducted in the field in the years 2016, 2017 and 2018 in the experimental area of the Crop Science Department of the Federal University of Santa Maria. The cultivar used was the Pea Grain 40. The values of the average mass of pods per plant, obtained in each harvest, were accumulated successively for each row of cultivation. After adjusting the nonlinear logistic model, the average pod mass per plant as a function of the accumulated thermal sum and the critical points were estimated by the partial derivatives of the adjusted function. The adjustment of the parameters of the logistic model and the critical points calculated by bootstrap resampling allowed comparisons to be made between the times of pea cultivation. The pea crop is influenced by environmental conditions, which interferes with the crop cycle and productivity. Season 1 was the most productive, with maximum increases in production in the shortest period (592.5 °C days-1 to produce 119.52 g plant-1), causing a high production peak in relation to the other seasons analyzed. The adjustment of the logistic model allowed to describe the pea production cycle over time at different growing seasons.
As crianças youtubers e o trabalho artístico infantil
Authors: Silva Alex Dylan Freitas , Lima Leonardo Tibo Barbosa , Rezende Lorena Carvalho
Published: August 2024

Este artigo teve como objetivo a análise dos limites legais para o exercício do trabalho infantil e suas repercussões no cotidiano das crianças youtubers. A metodologia utilizada foi a revisão bibliográfica – com a análise de conteúdo (teórico-dedutiva e dialética), de forma qualitativa e quantitativa. A conclusão foi de que tem aumentado exponencialmente o número de crianças trabalhando em plataformas digitais na condição de youtubers, sem uma resposta jurídica eficaz para as ilegalidades cometidas contra as vedações legais e constitucionais ao trabalho infantil (quando configurado no caso prático). Jurídica e politicamente a competência para conhecer das demandas relativas ao trabalho artístico infantil é da Justiça do Trabalho. Por fim, percebeu-se que se está diante de mais uma nova modalidade precarizante de trabalho plataformizado, que só ajuda a dificultar a aplicação da Lei.
Uma análise foucaultiana do conceito do reconhecimento do direito das sexualidades
Authors: Brum Amanda , Duro Dias Renato
Published: August 2024

Este estudo tem como objetivo analisar a partir do aporte de Michel Foucault a reestruturação do conceito do reconhecimento do direito das sexualidades. Para isso, vale-se da técnica da pesquisa da documentação indireta da revisão bibliográfica. Assim, realiza-se uma revisão bibliográfica ancorada fundamentalmente no aporte de Michel Foucault (1999, 2005, 2010, 2014a, 2014b). Para tanto, este escrito, além de contar com uma introdução e considerações finais inicialmente, estrutura-se em dois momentos. Inicialmente, repensa-se, a partir do aporte foucaultiano, a categoria das sexualidades e, em seguida, analisa-se a redefinição e reestruturação, a partir de Foucault, da concepção do reconhecimento do direito das sexualidades. Finalmente, defende-se que, seguindo as bases foucaultianas, torna-se fundamental repensar as sexualidades para além do sistema discursivo de verdades construído na sociedade ocidental, para que, a partir daí, possa-se caminhar em direção à reestruturação e redefinição do conceito de reconhecimento do direito das sexualidades a partir de bases emancipatórias e plurais
Vandick Londres da Nóbrega: um intelectual conservador no contexto educacional durante a ditadura militar no Brasil (1964-1979)
Authors: Pereira Larissa Freire , Jinzenji Mônica Yumi , Filgueiras Juliana Miranda
Published: August 2024

Este artigo analisa a atuação política e educacional de Vandick Londres da Nóbrega no contexto da ditadura militar brasileira. Professor de Latim e Diretor do Colégio Pedro II no período de 1964 a 1979, a trajetória da personagem é marcada por intensa divulgação de seus princípios e posicionamentos políticos por meio de livros, matérias em jornais, discursos, conferências proferidas em congressos e a atuação no Conselho Federal de Educação. Tais documentos subsidiam a discussão sobre a constituição do perfil conservador desse sujeito, em diálogo com os conceitos de intelectual engajado e intelectual mediador. Destacamos a proficuidade de sua produção escrita para a compreensão das manobras de negociação e resistência assumidas ao longo de seu percurso profissional durante o período ditatorial.
KARAKTERISTIK KEPRIBADIAN KONSELOR DALAM TOKOH PEWAYANGAN PUNTADEWA
Authors: Caraka N. B Rahadian Bagus , Zuhdi M. Sholihuddin
Published: August 2024

Counseling is the process of supporting a counselor (client) counselor with the goal of resolving the problems the counselor is experiencing. To support successful counseling, counselors need to pay attention to their personality competencies. These personality competencies are considered important to support the counseling process. However, the commonly used personality traits of advisors are the personality traits of effective advisors who come from abroad and have a different cultural sensibilities than Indonesia. The main purpose of this study is to identify and explain the character of Puntadewa, and the results of identifying and explaining the character of Puntadewa can be used as a reference for Indonesian consultants to develop effective consultant characteristics. To be able to use it. About local culture. The research method used by researchers is qualitative. The type of study used is library study. The results of this study show that there are six personality traits that can be derived from the Puntadewa doll character that can be used as a reference for Indonesian counselors based on local wisdom. (2) Courtesy; (3) Fairness; (4) Wise; (5) Honesty. (6) Simple; (7) patient. Keywords: Characteristics, Counselor, Puntadewa.
PEREMPUAN LESBIAN: IDENTIFIKASI PENYEBAB DAN METODE BIMBINGAN
Authors: Verolyna Dita , Kurnia Syaputri Intan , Warsah Idi
Published: August 2024

This study aims to identify the factors that cause women to become lesbi actors and the appropriate counseling guidance approach. This study uses a qualitative method with a phenomenological approach. Four lesbians in Rejang Lebong Regency, Bengkulu Province, were used as informants using in-depth interview techniques. The informants consisted of two butch lesbians and two femme lesbians. Based on the results of the interviews, it was found that there is no single factor that causes women to become lesbi actors. Many factors influence. The influence of hormones only occurs in butch type lesbians and heterosexual relationship trauma only occurs in femme type lesbians. Multifactor other than that is the lack of family attention, religious knowledge and wrong association. The characteristics of the butch type lesbian are very masculine and assertive and are not ashamed to show their identity. Contrary to women who prefer to hide and seem to cover up. The group guidance method can only be done for butch type lesbians while personal guidance must be done for the femme type. Both types of guidance can be done directly. Guidance is done by first introducing and listening more. This research does not look at the final product of the mentoring process but only focuses on identifying appropriate guidance methods based on the type of lesbian. Therefore future researchers can use the PAR method to see the success of the guidance process for both types of lesbians.
Keywords: Lesbian, Counseling Guidance, Women, Sexual Orientation
UPAYA MEMINIMALISIR AKSI PRANK MELALUI PENANAMAN PENDIDIKAN MORAL PADA REMAJA
Authors: Khoerunisa Nova , Nurus Sa’adah
Published: August 2024

Prank actions that are increasingly prevalent among teenagers are often without regard to the negative consequences, disrupting social order and reflecting moral decline. It is important to address this issue to protect the younger generation from harmful behavior and raise awareness of social responsibility. The purpose of this study is to discuss efforts to minimize prank actions through moral education in adolescents. Method. Applied in this research namely qualitative descriptive method whose sources are obtained from literature review. The results show that excessive pranks can trigger despicable behavior in adolescents, through the provision of moral education, adolescents will really want to be aware of good and bad things, and have a sense of compassion that can encourage adolescents to rethink their choice to do pranks. Moral education is effective in minimizing the negative impact of pranks by increasing adolescents' ethical awareness and social responsibility.
 
Keywords: Prank, Moral Education, Teenager.
Falling in the Midst of Crisis: The Collapse of the Mangkunegaran Autonomous Government in the Social Revolution Era, 1945-1946
Authors: Ramadhan Fauzan Syahru , Alamsyah Alamsyah , Rinardi Haryono
Published: August 2024

This article examines the social revolution in Surakarta, characterized by the anti-autonomous movement during the early years of the Indonesian Republic's independence, leading to the collapse of the Mangkunegaran autonomous government. Using historical methods, the article explores the initially positive relationship between the Mangkunegaran Duchy and the people in the late colonial period, evident in various factors such as support for education, economic initiatives, and infrastructure development. However, this relationship took a downturn during the social revolution due to external factors. Surakarta became a hub for radical movements, particularly the Anti-Autonomous movement, as the Mangkunegaran Duchy made unfortunate decisions. The study's goal is to uncover how the Mangkunegaran Autonomous Government navigated through the social revolution in Surakarta, even though it eventually collapsed. The study findings indicate that, facing a crisis after declaring independence, the Mangkunegaran Duchy made a critical error by betraying the Indonesian Republic and seeking to reinstate Dutch rule. In response, the people initiated a revolutionary movement. Ultimately, the Mangkunegaran Duchy failed to overcome the crisis, making misguided decisions and becoming victims of the revolution. They struggled to uphold the traditional politics and economy of the palace, which had endured for centuries and had been passed down through generations.
“De Moelijike Middenweg”: Association Politics between the Dutch East Indie and the Netherlands through Indische Toneel, 1913-1933
Authors: Nugroho Khairana Zata , Sulistiyono Singgih Tri , Puguh Dhanang Respati
Published: August 2024

This article discusses the endeavors to build a harmonious relationship between the colony of the Dutch East Indies and the motherland, the Netherlands, through the association politics in Indische toneel (Indies play) performances of Karina Adinda and Boeddhakind in 1913-1933. In the midst of the natives movement, where the natives put in motion their thoughts and ideas against the oppressive colonial government, a new cultural consciousness that desired a dialogue between East and West also appeared as the consequences of the implementation of the Dutch Ethical Policy. One of its aspects was performing art. Through historical method, this anomaly is examined through the performances of two Indische toneel namely Karina Adinda and Boeddhakind, Indische toneel that combined West dramaturgy with Javanese performances such as gamelan and traditional dances. The performances were produced in cooperation with organizations such as Vereeniging Oost en West, Het Nederlandsch-Indonesisch Verbond van Jongeren-Organisaties (NIVJO), and other Indonesian students in the Dutch East Indies and the Netherlands. The performances garnered disapproval from nationalists and praise from ethnicists
Does Intellectual Capital Moderate the Relationship Between Enterprise Risk Management and Market Performance? Evidence from Indonesian Banking Industry
Authors: Aisanafi Yuannisa , Djakman Chaerul Djusman
Published: August 2024

Despite an increasing number of studies on the link between enterprise risk management (ERM) and market performance which are still debatable, the literature has predominantly focused on relationship between them without considering moderating factors. This study not only introduces intellectual capital as a moderator variable that potentially moderates the ERM-market performance relationship, but also uses a comprehensive list of ERM measurement. This study analyzed degree of enterprise risk management (DERM) using Lundqvist’s comprehensive list of ERM measurement and Pulic’s value added intellectual coefficient (VAICTM) for intellectual capital in 99 banking companies that listed in Indonesia stock exchange for three years period. The result suggests that there is a positive significant relationship between DERM and market performance in Indonesian banking sector, by using comprehensive ERM measurement. Partially, leverage is the variable that has significant impact to market performance. Intellectual capital as moderating variable is also significant yet has weakening effect. The notable implication of this study is that the importance of comprehensive enterprise risk management and intellectual capital must be highly concerned by management as it will affect shareholder’s perception to the company
PENGARUH PERENCANAAN PAJAK DAN PROFITABILITAS TERHADAP MANAJEMEN LABA
Authors: Jesika Cebi Clara
Published: August 2024

Abstrak. Penelitian ini bertujuan untuk mengetahui pengaruh perencanaan pajak dan profitabilitas terhadap manajemen laba pada perusahaan otomotif dan komponen yang terdaftar di Bursa Efek Indonesia tahun 2017 – 2021. Penelitian ini merupakan jenis penelitian asosiatif. Teknik pengambilan sampel dilakukan dengan menggunakan teknik purposive sampling. Sehingga sampel yang diperoleh sebanyak 9 perusahaan otomotif dan komponen yang terdaftar di BEI tahun 2017 - 2021. Teknik pengumpulan data yang digunakan adalah dokumentasi. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis regresi linier berganda dengan alat bantu software SPSS 24. Hasil penelitian ini menunjukkan bahwa perencanaan pajak tidak berpengaruh terhadap manajemen laba. Profitabilitas tidak berpengaruh dan tidak signifikan terhadap manajemen laba. Kemudian tidak adanya pengaruh yang signifikan antara perencanaan pajak dan profitabilitas terhadap manajemen laba secara simultan.
THE INFLUENCE OF MANAGERIAL ABILITY TOWARDS ACCOUNTING CONSERVATISM (A Study in Non-Cyclical Companies Listed on IDX)
Authors: Handoko Maria Evelyn Jenita , Fuad Fuad
Published: August 2024

The purpose of this study is to examine whether managerial ability affects positively to conditional and unconditional conservatism among non-cyclical companies listed on Indonesia Stock Exchange (IDX). The data used in this study uses secondary data taken from the company’s annual report that is provided in Indonesian Stock Exchange website as well as Bloomberg’s Financial Analysis (FA) and Equity Screening (EQS) for the period 2012 to 2022. In this study, the population are non- cyclical or consumer goods companies listed on the Indonesia Stock Exchange (IDX) and the sampling method used is purposive sampling technique. In the process of analysis, this research uses multiple linear regression with robust standard error method. The results of the analysis show that managerial ability affects in mixed way such as positive, negative and some even have no effect either to conditional conservatism. In addition, it affects positively to unconditional conservatism. To the best of the authors’ knowledge, few studies have explored the influence of managerial ability on accounting conservatism. For non-cyclical firms, this study’s result gives significant contribution which focuses on examining the association between managerial ability and accounting conservatism, which has not been widely used in local studies.
The Effect of Administration of Sapodilla Leaf Extract Cream (Manilkara Zapota (L.) P. Royen) On the Expression of PDGF And Il-10
Authors: Maharani Sahara , Sumarawati Titiek , Hermansyah Dedi
Published: August 2024

Background: Sunburn is an acute inflammatory skin condition caused by exposure to UV rays. Excessive exposure increases the production of  ROS which, if accumulated, can lyse growth factors, one of which is PDGF and also form IL-10 immune suppression. This condition can be influenced by providing antioxidants and anti-inflammatories such as those contained in sapodilla leaf extract (Manilkara zapota (L.) P. Royen) which has many benefits such as anti-inflammatory, anti-pyretic, anti-tumor, antioxidant, anti-microbial, anti- diabetic, anti-lipid and anti-aging. In previous research, the polyphenol content in Sapodilla leaves was a potential source of inhibiting ROS. However, until now the role of Sapodilla leaf extract on UVB burns has not been studied.Objective: The aim of this research is to determine the effect of administering Sapodilla leaf extract cream on PDFG and IL-10 in Wistar rats that experienced burns due to exposure to UVB.Method: Experimental research with a post test only control group design approach. This research used 24 Wistar rats exposed to UVB rays which were divided into 4 groups (normal control, control with cream, 25% Sapodilla leaf extract cream, and 50% Sapodilla leaf extract cream). The ELISA (Enzyme-Linked Immunosorbent Assay) method was used to analyze PDGF and IL-10 levels in skin tissue.Results: The highest ratio of PDGF levels was found in (K3) 2.915 ± 0.368. The results of the one way Anova analysis had a p value of 0.024 (p<0.05) which stated that there were significant differences between treatment groups. In IL-10 levels there was an increase in K3 255.9 ± 35,563. In IL-10, the results of one way Anova analysis had a p value of 0.240 (p>0.05), which stated that there were no significant differences between treatment groups.Conclusion: Administration of sapodilla leaf extract cream at a dose of 25% had a significant effect on increasing PDGF levels and a slight increase in IL-10 in mice that experienced burns due to exposure to UVB.
The Relationship between the Physical Environment of the House and Family Behavior with the Incidence of Acute Respiratory Disease in Toddlers in the Koeloda Health Center
Authors: Bupu Ferdinanda Karolina , Landi Soleman , Ndoen Honey Ivon
Published: August 2024

Abstract  Introduction: Acute respiratory infection (ARI) is a disease that affects the respiratory tract, including the nose, throat, and lungs. Based on data from the Ngada Regency Health Center, ARI remains a serious problem and continues to increase from 4,92% in 2020 to  5.54% in 2021. This study aimed to determine the relationship between the physical environment of the home and family behavior and the Incidence of ARI in toddlers.  Method: Observational analytical research with a cross-sectional design was used. The population in this study were all toddlers in the Koeloda Health Center area, totaling 357 toddlers and the sample in this study were some of the toddlers totaling 185 toddlers. Random cluster sampling was used in this study. Data collection was conducted through interviews using research instruments in the form of questionnaires, and measurements using research instruments in the form of roll meters. This analysis uses the Chi square testResults :  The results showed that there was a relationship between the type of household fuel (P=0.007), behavior of bringing toddlers to the kitchen (P= 0.002), and Incidence of ARI in toddlers. There was no relationship between room occupancy density (P = 0.078), ventilation area (P =0.235), floor type (P =0.291), and smoking behavior (P =1.000) and the incidence of ARI.  Conclusion :  There is a relationship between the type of household fuel and the behavior of bringing toddlers to the kitchen when cooking, and the Incidence of ARI in toddlers.
Screening for Emergent Threats to Maternal and Newborn Health: A Literature Review
Authors: Morse Avery , Mutiara Dewi Aulia Ulfah , Farinisa Aliva Nabila , Winarni Sri , Kartasurya Martha Irene
Published: August 2024

AbstractIntroduction: Though global trends for maternal and newborn mortality have improved, the COVID-19 pandemic had a negative impact on maternal and newborn health (MNH), increasing risk of complicated births. Indonesia’s Ministry of Health (IMOH) has made significant progress in expanding MNH services; however, challenges remain in improving screening for emergent threats (ET) to MNH, which includes emerging infectious diseases. This review aimed to compare antenatal care (ANC) standards in Indonesia to WHO guidelines and to evaluate the role of laboratory services and ultrasound (USG) for ANC.Methods: A narrative literature review was conducted through PubMed and Google Scholar. Articles were also found from the IMOH and the World Health Organization (WHO). Search terms included antenatal care, laboratory, ultrasound, and doppler, yielding sixteen articles in total. Nine articles published between 2010 and 2023 were included for review.Results: Compared to WHO standards of 8 ANC visits and 1 USG, Indonesia has a lower number of required ANC visits (6), but a higher requirement for USG visits (2); though, conflicting evidence exists for USG recommendations during pregnancy. One article evaluated standard laboratory tests administered during the first ANC visit, finding no records of testing at the puskesmas (primary healthcare center) level, while another cited improved infectious disease (ID) detection using screening questionnaires.Conclusion: In comparison to global standards, Indonesia may benefit from an increased number of ANC visits, ID screening in non-endemic areas, and studies on adherence to national screening guidelines. Further research is needed to evaluate the optimal timing of USG during the prenatal period.
Ketimpangan Ekonomi Jawa dan Luar Jawa dan Perkembangan Perdagangan Antarpulau di Indonesia
Authors: Rinardi Haryono , Indrahti Sri , Masruroh Noor Naelil
Published: August 2024

This article discusses the relationship between economic inequality in Java and outer Java and its relationship with inter-island shipping and trade. By using the historical method, this study proves that economic inequality has been happening since the colonial until the independence period. This inequality arose because the role played by Java in its economic relations with outer Java became very dominant and decisive. Java became a kind of intermediary in economic relations outside Java with the international world. This role has occurred since the colonial period and did not change until independence. Java provides added value to commodities from outside Java, which are then resold to international markets. Therefore, Java has always had an advantage in economic relations with outer Java. This situation created economic disparities in relation to provincial regional income in present-day Indonesia.
Transformasi Kesehatan melalui Perbaikan Sanitasi: Kiprah dr. Budi Laksono sebagai Relawan Kesehatan, 1991-2019
Authors: Hutapea Ckrystin Natalia , Utama Mahendra Pudji
Published: August 2024

This article exposes dr. Budi Laksono's career journey as a volunteer aimed at improving the health of Indonesian people, transitioning them from less healthy to healthier lifestyles. To uncover dr. Budi Laksono's role in improving societal health, this study adopts a historical method with a biographical approach. This approach aims to unveil the actions taken by dr. Budi Laksono that have contributed to this endeavor. It is known that dr. Budi Laksono is a doctor who deeply concerned with Indonesian public health, encountered numerous patients suffering from gastrointestinal diseases during his tenure as a general practitioner. These diseases were attributed to unsanitary living conditions in the area. Driven by a desire to address this issue, he focused on enhancing the health of the villagers, whose known for their suboptimal sanitation. His experiences in health improvement initiatives in the region inspired him to advocate for the importance of sanitation nationwide. He initiated various movements, including the "WC4allfamily" campaign, aimed at promoting the construction of latrines for all families. Through these efforts, he successfully elevated the living standards of the community, leading to positive health outcomes. His impactful contributions were recognized by several organizations, earning him prestigious awards.
Perbandingan Visualisasi Motif Kalpataru pada Berbagai Candi Peninggalan Mataram Kuno Abad 8-10 Masehi
Authors: Rosalinda Herliyana , Amzy Nurulfatmi , Limbong Edo Galasro
Published: August 2024

This study examines the diverse visualizations of the Kalpataru motif in ancient Mataram temples. As significant religious symbols, these temples embodied societal values and were constructed with meticulous attention to materials, architecture, and aesthetics. By chronologically comparing the Kalpataru motif in Hindu and Buddhist temples, this research explores its evolving meaning and form. The Kalpataru, representing purity and sacredness in Hindu-Buddhist thought, appears prominently in temples such as Borobudur, Mendut, Pawon, Prambanan, and Sojiwan. While its origins lie in Buddhist symbolism, associated with Siddhartha Gautama's enlightenment, the motif underwent significant transformation in Hindu temples, particularly Prambanan, where it became more decorative and incorporated animal figures. This study employs a historical methodology, encompassing heuristic, critical, interpretive, and historiographical stages, to analyze these changes and their implications for understanding ancient Mataram culture.
Chemical composition’s effect on Solanum nigrum Linn.’s antioxidant capacity and erythrocyte protection: Bioactive components and molecular docking analysis
Authors: Aouadi Abdelatif , Saoud Djamila Hamada , Rebiai Abdelkrim , Ibrahim Mona H. , Messaoudi Mohammed , Alia Khaoula , Zidane Halima , Atoki Ayomide Victor , Abd El-Mordy Fatma Mohamed
Published: August 2024

Oxidative stress has been widely believed to be the mechanism responsible for developing diseases such as arthritis, asthma, dementia, and aging. Solanum nigrum Linn. is a common edible medicinal herb that belongs to the family Solanaceae which has more than 180 chemical components that have so far been discovered. The main bioactive components of these are steroidal saponins, alkaloids, phenols, and polysaccharides. This article presents comparative phytochemical profiling including total phenolic, total flavonoid, alkaloid, proanthocyanidins, tannin, and vitamin C contents of three Algerian S. nigrum samples collected from three different locations in the Algerian desert. Additionally, the potential antioxidant activity of the three samples was assessed by 2,2-diphenyl-1-picrylhydrazyl, ferric reducing antioxidant power, and oxidative hemolysis inhibition assay. Moreover, the correlation between the major phenolic phytoconstituents previously reported and isolated from the plant and antioxidant activity has also been done by in silico molecular docking. Ten bioactive compounds were docked with selected proteins, arachidonate-5-lipoxygenase (PDB: 6n2w) and cytochrome c peroxidase (PDB: 2x08), to check their affinity with binding sites of these proteins for the possible mechanism of action. The docking scores suggest that S. nigrum’s quercetin and kaempferol may play a significant role in its antioxidant action.
Construction of platelet count-optical method reflex test rules using Micro-RBC#, Macro-RBC%, “PLT clumps?” flag, and “PLT abnormal histogram” flag on the Mindray BC-6800plus hematology analyzer in clinical practice
Authors: Fei Yang , Xiong Zhi-gang , Huang Liang , Zhang Chi
Published: August 2024

Objectives

Utilizing RBC or PLT-related parameters to establish rules for the PLT-O reflex test can assist laboratories in quickly identifying specimens with interfered PLT-I that require PLT-O retesting.

Methods

Prospective PLT-I and PLT-O testing was performed on 6857 EDTA-anticoagulated whole blood samples, split randomly into training and validation cohorts at a 2:3 ratio. Reflex and non-reflex groups were distinguished based on the differences between PLT-I and PLT-O results. By comparing RBC and PLT parameter differences and flags in the training set, we pinpointed factors linked to PLT-O reflex testing. Utilizing Lasso regression, then refining through univariate and multivariate logistic regression, candidate parameters were selected. A predictive nomogram was constructed from these parameters and subsequently validated using the validation set. ROC curves were also plotted.

Results

Significant differences were observed between the reflex and non-reflex groups for 19 parameters including RBC, MCV, MCH, MCHC, RDW-CV, RDW-SD, Micro-RBC#, Micro-RBC%, Macro-RBC#, Macro-RBC%, MPV, PCT, P-LCC, P-LCR, PLR,“PLT clumps?” flag, “PLT abnormal histogram” flag, “IDA Anemia?” flag, and “RBC abnormal histogram” flag. After further analysis, Micro-RBC#, Macro-RBC%,“PLT clumps?”, and “PLT abnormal histogram” flag were identified as candidate parameters to develop a nomogram with an AUC of 0.636 (95 %CI: 0.622–0.650), sensitivity of 42.9 % (95 %CI: 37.8–48.1 %), and specificity of 90.5 % (95 %C1: 89.6–91.3 %).

Conclusions

The established rules may help laboratories improve efficiency and increase accuracy in determining platelet counts as a supplement to ICSH41 guidelines.
Spatial relationship description model and algorithm of urban and rural planning in the smart city
Authors: Xu You , Gao Juan , Li Man
Published: August 2024

With the advancement of the concept of smart cities, research on urban and rural planning is also developing rapidly. How to make the spatial relationship description model in the context of smart cities more in line with the actual situation of urban development is still a problem to be solved. This article focuses on the spatial relationship description model and algorithm of urban and rural planning results in the context of smart cities, studies the impact of urban industrial structure under the action of the spatial relationship description model, and evaluates the impact of policy as well as the impact of smart city construction on urban green innovation efficiency. Its dynamic effects and urban heterogeneity are expanded and analyzed. The research results show that compared with the traditional ordinary least squares (OLS) technology, geographically weighted regression (GWR) has significantly improved the solution results of the model, the R value is reduced by 0.3–0.4, the residual sum of squares value is significantly reduced, and the Akaike information criterion value is significantly improved. For the same training samples and test data, compared with the OLS technology, the mean-squared error reduction rate of the prediction results obtained by the GWR technology basically reached more than 50%, especially in Experiment 4; it reached 57.9%, which shows a very obvious advantage in prediction accuracy. Smart city policies have a significant role in promoting green innovation efficiency in pilot areas, and over time, innovation efficiency has increased year by year, and the policy effects are particularly prominent in the eastern coastal areas with a good development foundation. Therefore, the construction of smart cities is based on the characteristics of the region, and it is necessary to seek a sustainable development path based on the conditions of the region.
Optimizing agricultural land use: A GIS-based assessment of suitability in the Sana River Basin, Bosnia and Herzegovina
Authors: Sabljić Luka , Lukić Tin , Bajić Davorin , Marković Rastko , Spalević Velibor , Delić Dragica , Radivojević Aleksandar R.
Published: August 2024

The research subject is the application of geographic information systems (GIS) in assessing land suitability for agriculture in the Sana River Basin in Bosnia and Herzegovina. The aim of the research is to apply the analytic hierarchy process (AHP) in identifying suitable areas for agricultural production. Within the AHP framework, the following factors were considered: pedology, land use, elevation, slope, aridity index, and distance from rivers. The results of the suitability assessment underwent reclassification (RP) and cluster analysis processes (CAPs). It was found that very unsuitable land (1) covers an area of 0.15% (RP) or 5.83% (CAP), unsuitable land (2) covers 3.44% (RP) or 17.52% (CAP), conditionally suitable land (3) covers 32.11% or 28.47% (CAP), suitable land (4) covers 56.29% or 28.57% (CAP), and very suitable land (5) covers 7.98% (RP) or 19.59% (CAP). At the study area level, a supervised classification process was conducted to identify land use classes: meadows/pastures, water, forest, agricultural, and built-up areas. RP and CAP results were overlaid with supervised classification results to determine the amount of land used for agricultural purposes within each suitability class. It was determined that currently, for agricultural purposes, 0.04 km2 (RP) or 0.88 km2 (CAP) of very unsuitable land (1) is used, 0.41 km2 (RP) or 7.28 km2 (CAP) of unsuitable land (2), 15.75 km2 (RP) or 27.52 km2 (CAP) of conditionally suitable land (3), 185.15 km2 (RP) or 107.06 km2 (CAP) of suitable land (4), and 42.99 km2 (RP) or 101.65 km2 (CAP) of very suitable land (5). The research findings hold substantial importance in elucidating both the potential and constraints of land use practices as a vital natural resource within agriculture. They also have practical importance for relevant institutions in terms of agricultural sector development and making timely land use planning decisions for sustainable development.
On the social meanings of avoiding fully-articulated explicatures and the role of pragmatics in utterance explication
Authors: Jarrah Marwan , Ali Sukayna , Aljabali Yousef , Al-Jabri Hanan
Published: August 2024

The term ‘explicatures’ pertains to the inferential developments made of utterances with the objective of attaining a greater degree of clarity by the speaker (Sperber and Wilson 1986). It was first introduced by relevance theory to provide evidence that the explicit part of communication may contain a pragmatically inferred material, which facilitates communication and makes it more relevant (Carston. 2000. Explicature and semantics. UCL Working Papers in Linguistics 12. 44–89). Nevertheless, there are instances where explicatures are deliberately not fully articulated in order to achieve certain social meanings as well as communicative goals. This research article examines the social functions, which are accomplished when communicators do not articulate pragmatically inferred material which is part of the explicit content of the utterance. Based on the analysis of genuine communications, obtained from real-life interactions from Jordanian Arabic, this article demonstrates that the act of not fully articulating explicatures serves certain social purposes, such as not inviting evil eye, not damaging the positive face of the addressee or the person under discussion, and avoiding the explicit mentioning of delicate matters like illnesses and social taboos; hence conforming to the established social conventions. Furthermore, the results referred to a remarkable association between particular areas of explicatures identification and certain social functions.
Neapoli commorantes: chiese nazionali e comunità forestiere nel viceregno spagnolo tra Cinque e Seicento
Authors: Sorrentino Vincenzo
Published: August 2024

This article deals with national communities in Naples and their churches during the early modern period. Florentine, Lombard, and Genoese merchants had all received special privileges that exempted them from taxes on their trading and from local jurisdiction. These three nationes had different forms of government and the foundations and following stories of their churches differed dramatically. In fact, each of them fostered its own identity in several ways, hiring artists or employing iconographies from the motherland, allowing the coexistence of a ‘pantheon’ of patron saints or decorating their churches with techniques that were more common abroad. The Genoese nation is probably the most difficult to outline, as often its members decided to spread their patronage into the most important Neapolitan churches rather than gather in San Giorgio dei Genovesi.
Prognostic factors of papillary and follicular carcinomas based on pre-, intra-, and post-operative findings
Authors: Ito Yasuhiro , Miyauchi Akira
Published: August 2024

Graphical abstract

Papillary and follicular thyroid carcinomas (PTC and FTC) are prominent malignancies that originate from thyroid follicular cells. PTC is usually diagnosed via preoperative cytology, and large tumor size, clinical node metastasis, and distant metastasis constitute preoperative prognostic factors. Gross extrathyroidal and extranodal tumor extensions have a significant prognostic impact, are evaluated intraoperatively, and are useful for determining the extent of surgery. Aggressive variants, such as tall cell and hobnail variants, a high Ki-67 labeling index (LI), and somatic gene mutations are prognostic factors in postoperative pathological and molecular examinations. In contrast, FTC is generally diagnosed based on postoperative pathology. Large tumor size and M factors have prognostic value; however, the findings of pathological examinations are very important. FTCs are classified as minimally invasive, encapsulated angioinvasive, and widely invasive FTCs. Widely invasive FTC with vascular invasion (VI) and encapsulated angioinvasive FTCs with extensive VI have a poor prognosis, whereas widely invasive FTC without VI has an excellent prognosis, which is similar to that of minimally invasive FTC. This indicates that VI is a considerably more important prognostic marker than capsular invasion. For postoperative follow-up, dynamic markers such as the thyroglobulin-doubling rate (DR), metastatic tumor volume-DR, and change in the neutrophil-to-lymphocyte ratio are important and are useful for evaluating the effectiveness of treatments, such as radioactive iodine therapy and molecular targeted therapy, for recurrent lesions. For clinicians, it is important to accurately evaluate prognostic markers of PTC and FTC in the pre-, intra-operative, and post-operative phases.
Infusing the Engineer Design Process into Education
Authors: Zhou Longjun
Published: August 2024

The engineering design process (EDP) is an iterative decision-making process, in which basic science, math, and engineering concepts are applied to develop optimal solutions to meet an established objective (Mangold & Robinson, 2013). There is no unitary standard for the EDP, and researchers have different ideas about the basic steps that should be included in the process. In practice, the EDP may varies by discipline and project, but it’s essential features typically include: (1) starting with the definition of the problem or needs; (2) being open-ended with multiple possible solutions; (3) involving mathematical modeling and scientific analysis; (4) being highly iterative (Atman et al., 2007; Hynes, 2012; Berland et al., 2014).