bluuebunny/crossref_metadata_2025 huggingface dataset:
K-POP in BBC News: A Big Data Analysis
Authors: Kang Namkil
Published: February 2023

The main goal of this paper is to analyze 40 pieces of BBC news broadcasted from 4th, 1, 2020 to 21st, 12, 2022 regarding K-pop. As a theoretical tool for this goal, we used the software package NetMiner. A point to note is that one word has the highest frequency (1,005 tokens) and the highest proportion (0.507). A further point to note is that in the word cloud, the noun BTS occurs as the biggest in size. This in turn implies that it is the most frequent one and thus it counts as the most significant. With respect to topics occurred in 40 pieces of BBC news, it is interesting to note that topic 1 was the most widely used one, followed by topic 8, topic 7, topic 2, and topic 9, in that order. Talking about major words occurred in 40 pieces of BBC news, the word BTS was the most occurred one, followed by the word fan, the word group, the word band, and the word year (the word member), in descending order. This paper argues, on the other hand, that the word BTS has the highest in-degree centrality (0.454545). This in turn indicates that the word BTS counts as the most significant or popular. This paper further argues that the word BTS has the highest in-closeness centrality (0.594310). More specifically, the distance among the word BTS and other nodes is the shortest, thereby counting as the most significant and important.
Validation of TREK1 ion channel activators as an immunomodulatory and neuroprotective strategy in neuroinflammation
Authors: Schroeter Christina B. , Nelke Christopher , Schewe Marcus , Spohler Lucas , Herrmann Alexander M. , Müntefering Thomas , Huntemann Niklas , Kuzikov Maria , Gribbon Philip , Albrecht Sarah , Bock Stefanie , Hundehege Petra , Neelsen Lea Christine , Baukrowitz Thomas , Seebohm Guiscard , Wünsch Bernhard , Bittner Stefan , Ruck Tobias , Budde Thomas , Meuth Sven G.
Published: February 2023

Modulation of two-pore domain potassium (K2P) channels has emerged as a novel field of therapeutic strategies as they may regulate immune cell activation and metabolism, inflammatory signals, or barrier integrity. One of these ion channels is the TWIK-related potassium channel 1 (TREK1). In the current study, we report the identification and validation of new TREK1 activators. Firstly, we used a modified potassium ion channel assay to perform high-throughput-screening of new TREK1 activators. Dose-response studies helped to identify compounds with a high separation between effectiveness and toxicity. Inside-out patch-clamp measurements of Xenopus laevis oocytes expressing TREK1 were used for further validation of these activators regarding specificity and activity. These approaches yielded three substances, E1, B3 and A2 that robustly activate TREK1. Functionally, we demonstrated that these compounds reduce levels of adhesion molecules on primary human brain and muscle endothelial cells without affecting cell viability. Finally, we studied compound A2 via voltage-clamp recordings as this activator displayed the strongest effect on adhesion molecules. Interestingly, A2 lacked TREK1 activation in the tested neuronal cell type. Taken together, this study provides data on novel TREK1 activators that might be employed to pharmacologically modulate TREK1 activity.
Computational resolution in single molecule localization – impact of noise level and emitter density
Authors: Hockmann Mathias , Kunis Stefan , Kurre Rainer
Published: February 2023

Classical fluorescence microscopy is a powerful technique to image biological specimen under close-to-native conditions, but light diffraction limits its optical resolution to 200–300 nm-two orders of magnitude worse than the size of biomolecules. Assuming single fluorescent emitters, the final image of the optical system can be described by a convolution with the point spread function (PSF) smearing out details below the size of the PSF. In mathematical terms, fluorescence microscopy produces bandlimited space-continuous images that can be recovered from their spatial samples under the conditions of the classical Shannon-Nyquist theorem. During the past two decades, several single molecule localization techniques have been established and these allow for the determination of molecular positions with sub-pixel accuracy. Without noise, single emitter positions can be recovered precisely – no matter how close they are. We review recent work on the computational resolution limit with a sharp phase transition between two scenarios: 1) where emitters are well-separated with respect to the bandlimit and can be recovered up to the noise level and 2) closely distributed emitters which results in a strong noise amplification in the worst case. We close by discussing additional pitfalls using single molecule localization techniques based on structured illumination.
Elektrische Levitationsdetektion für die Verwendung im Tissue Engineering
Authors: Scheunemann Stefan , Pientschke Christoph , Zabarylo Urszula Joanna , Raum Kay
Published: February 2023

Die Züchtung und Gestaltung biologischen Gewebes im Labor (Tissue Engineering) verspricht breite medizinische Anwendung. Die notwendige Strukturierung der künstlichen Gewebe kann mittels stehender Ultraschallwellen durch Levitation erfolgen. In diesem Beitrag wird eine Methode zur elektrischen Detektion der Levitation und Experimente zu ihrer Verifizierung vorgestellt. Die Ultraschallwellen werden mit piezoelektrischen Wandlern erzeugt. Die Kontrolle der Levitation beruht auf der Auswertung der Sendespannung. Optische Aufnahmen levitierter Kunststoffpartikel erlaubten die frequenzabhängige Ermittlung der Levitationsebenenabstände und eine Korrelation zu den Sendespannungen. Es zeigte sich, dass die Levitationsbedingung über einen relativ breiten Frequenzbereich erfüllt ist. Durch Berücksichtigung der frequenzabhängigen Sendeleistung kann mittels einer normierten Kurve ein gleichmäßiger Schalldruck über den gesamten für die Levitation relevanten Frequenzbereich eingestellt werden. Die gewonnenen Ergebnisse fließen in die Entwicklung eines Gerätes ein, mit dem parallel mehrere Proben für das Tissue Engineering per Levitation gezielt strukturiert werden können. Die Proben werden dabei nutzerfreundlich in Silikon- oder Teflon-Kammern prozessiert, indem ein Ultraschallsender und eine Reflektorplatte verwendet werden. Damit können Versuchsreihen zum Tissue-Engineering effizienter als bisher durchgeführt werden.
Problems of Sweden’s Accession to NATO
Authors:   Institute of Europe, Russian Academy of Science, Plevako Natalia
Published: February 2023

The article analyzes the processes in Swedish society and state stemming from the decision of Sweden and Finland to join NATO. The party-political unity is demonstrated. At the same time, Sweden faces significant foreign policy difficulties in implementing its plans to join NATO, especially after the burning of the Koran in Stockholm on January 21st, which led to Turkey's attempts to "punish" Sweden by blocking its way to NATO.
PERBEDAAN POSITIVE YOUTH DEVELOPMENT (PYD) BERDASARKAN JUMLAH DAN TIPE EKSTRAKURIKULER YANG DIIKUTI REMAJA DI KOTA BOGOR
Authors: Adeyasa Rama
Published: February 2023

This study has attempted to analyze the Positive Youth Development (PYD) perspectives as a measuring instrument for adolescent. 324 adolescences from 12 Senior High School both General and Vocational from Bogor were analyzed using questionnaire of quantitative study. This study has shown that there based on the number of extracurricular activities joined by student, the more they joined, the higher the score of 5Cs PYD, except for them who joined three extracurricular activities. Based on the type of extracurricular activities, C1, C2, C4, and C5 was highest for sport extracurricular activities while C3 is from the art type. Based on combination if the extracurricular activities, the highest 5Cs PYD score was found in student joined all the sport combination type, and the lowest score found in all of academic combination type
AKSI SOSIAL GERAKAN UNTUK KESEJAHTERAAN TUNARUNGU INDONESIA JAKARTA (GERKATIN JAKARTA) TERHADAP PENYANDANG DISABILITAS RUNGU
Authors: Sarah Agusti Siti
Published: February 2023

This study aims to determine participation and benefits in the management of the Serasi Garbage Bank with the formulation of the problem: (1) How does public participation in the management of the Serasi Garbage Bank in Dago Benda Baru Pamulang South Tangerang  (2) What are the benefits of the Serasi Garbage Bank in the Dago Benda Baru Pamulang Tangerang area South. The research methodology conducted by researchers is research conducted through a descriptive qualitative approach. Qualitative research is research that produces analytical procedures that do not use statistical analysis procedures or other quantitative methods, namely data obtained in the form of words, images and behavior. Through the Serasi Garbage Bank program, is a program that establishes and invites the community to manage household waste properly, the Serasi Garbage Bank program is an individual and collective waste management system with the principle of recycling cooperation with business partners.The benefits of managing the Serasi Garbage Bank, on the social aspects of the community, are concerned about waste and the environment. Economic aspects are still relatively small or a little income from weighing but can be an added value for the community. This aspect of the environment becomes cleaner, more beautiful and safer.
PEMBERDAYAAN MASYARAKAT DALAM PERKUMPULAN PENCAK SILAT CINGKRIG SERBAGUNA MELALUI PROGRAM PELATIHAN PENCAK SILAT
Authors: Hidayatullah Taufik
Published: February 2023

Silat Cingkrig merupakan faktor penyatu dan pengikat dari masyarakat Betawi. Hal ini bisa dibuktikan bahwa silat cingkrig banyak digunakan dalam adat Betawi pada acara- acara, seperti pernikahan yaitu palang pintu. Namun seiring berjalannya waktu, kemajuan teknologi baik dalam bidang teknologi informasi maupun teknologi transportasi mendorong munculnya produk-produk kebudayaan baru dalam masyarakat yang telah membuat tradisi kebudayaan Betawi kian jarang terlihat. Akhirnya sebagian generasi muda kurang mengetahui tradisi kesenian Betawi, salah satunya Silat Cingkrig dan tradisi buka palang pintu pada perkawinan masyarakat Betawi. Keberadaan sebuah “Perkumpulan Pencak Silat Cingkrig Serbaguna” yang didirikan oleh H. Sinan memberikan dampak berupa perubahan ekosistem lingkungan hidup dan perubahan perilaku sosial dan budaya. Pendekatan pemberdayaan masyarakat menjadi salah satu cara dalam pengembangan masyarakat mandiri. Salah satunya adalah melalui pembentukan perkumpulan tersebut yang kemudian dilatih agar mempunyai kemauan,  pengetahuan, dan kemampuan untuk mandiri. Pemberdayaan merupakan hakikat pendidikan karena apa yang disebut dengan pendidikan adalah usaha untuk memberdayakan individu, meningkatkan kemampuan individu, dan mengembangkan potensi yang ada pada diri individu tersebut. Penelitian ini dilakukan dengan menggunakan jenis penelitian kualitatif yang bersifat deskriptif dengan teknik pengumpulan data yang digunakan yaitu observasi, wawancara, dan studi dokumentasi. Adapun teori yang digunakan dalam penelitian ini yaitu teori tahapan pemberdayaan yang dikemukakan oleh Muhtadi dan Hermansyah yang menjelaskan tahapan POAC (Planning, Organizing, Actuating, dan Controlling). Hasil dari penelitian ini menunjukan bahwa dengan adanya Perkumpulan Pencak Silat Cangkring Serbaguna tersebut dengan menggunakan proses pemberdayaan yang dilakukan menghasilkan dua hasil yaitu, dapat meningkatkan pelestarian budaya Betawi dan meningkatkan kesejahteraan para aggotanya untuk dapat mendapatkan penghasilan.
Veleszületett szívbetegségek 60 éves kor felett.
Authors: Ambrus Nóra , Havasi Kálmán , Halcsik Renáta , Forster Tamás , Nemes Attila
Published: February 2023

Bevezetés: A gyermekkardiológia, az intervenciós kardiológia és
a szívsebészet fejlődésével a felnőtt congenitalis szívbetegek száma és a
populáció átlagéletkora is nő. A populáció átlagéletkorának növekedésével
azonban gyakoribb a társbetegségek megjelenése, amelyek új diagnosztikai és
kezelésbeli nehézségeket jelentenek ebben a komplex betegcsoportban.
Célkitűzés: A jelen vizsgálat célja a fontosabb klinikai és
echokardiográfiás paraméterek összehasonlítása volt az általunk gondozott 40 év
alatti, 40 és 59 éves kor közötti és a 60. életévüket betöltött felnőtt
congenitalis szívbetegek esetén. Módszer: Összesen 346 beteg
adatait dolgoztuk fel, közülük 154 beteg volt 40 év alatti, 133 beteg volt 40 és
59 éves kor közötti, és 59 beteg töltötte be a 60. életévét. A vizsgálatba
minden olyan felnőtt congenitalis szívbeteget bevontunk, akinél ambuláns
vizsgálat történt. A fizikális vizsgálat részeként meghatároztuk a
szívelégtelenség New York Heart Association (NYHA) szerinti funkcionális
stádiumát, elektrokardiográfia, echokardiográfia és 6 perces sétateszt is
történt. Eredmények: 40 éves kor felett szignifikánsan nagyobb
arányban fordultak elő NYHA III–IV. funkcionális stádiumú szívelégtelenségben
szenvedő betegek, szignifikánsan nagyobb volt azoknak a betegeknek az aránya,
akik bal kamrai ejekciós frakciója 55%-nál alacsonyabb volt, és a társbetegségek
gyakorisága is nagyobb volt ebben a csoportban. A ritmuszavarok előfordulási
aránya hasonló volt minden korcsoportban, de emelkedő tendenciát lehetett látni
az életkor előrehaladtával. Következtetés: A felnőtt korú,
congenitalis szívbetegséggel élő betegeknél az életkor növekedésével
társbetegségek jelenhetnek meg, amelyek hatással vannak az alapbetegségükre,
prognózisukra. A betegek utánkövetésére jelenleg alkalmazott vizsgálómódszerek
mellett egyéb vizsgálatok bevezetésére lehet szükség a reoperáció, az
intervenció vagy az esetleges szívtranszplantáció idejének kiválasztásában. Orv
Hetil. 2023; 164(6): 219–226.
Az egészségügyben közfeladatot ellátó személyek büntetőjogi védelme
Authors: Minkó-Miskovics Mariann , Ács Gábor
Published: February 2023

Bevezetés: Az egészségügyben dolgozó személyek mint közfeladatot
ellátó személyek a 20. század második felétől fokozott büntetőjogi védelmet
élveztek, és ezen speciális büntetőjogi védelem a mai egészségügyben dolgozó
személyek életére és munkájára is hatással van. Célkitűzés: A
jelen tanulmány célja annak bemutatása, hogyan alakult ki az egészségügyben
dolgozó személyek fokozott büntetőjogi védelme a 20. század második felétől
kezdődően, hogyan változott és bővült ez a speciális alanyi kör, és ténylegesen
mit foglalt magában. A tanulmány célja továbbá annak megjelenítése, hogy az ezen
speciális közfeladatot ellátó személyek elleni erőszak bűncselekménye a
kriminálstatisztika tükrében hogyan jelent meg. Módszer: A
kutatás a kapcsolódó jogszabályok, joggyakorlat és jogirodalom áttekintésével
történt, illetve a Legfőbb Ügyészség részére megküldött adatkérésre adott
válaszban foglalt adatok feldolgozásával és elemzésével.
Eredmények: A közfeladatot ellátó személy elleni erőszak
passzív alanyi körének bővülése révén ugyancsak bővült az egészségügyben dolgozó
személyek köre, és a 20. század közepétől kezdődően a modern magyar
büntetőjogban egyre szélesebb körben részesülnek büntetőjogi védelemben ezek a
személyek. A joggyakorlat tovább bővítette a védendő személyek körét, aminek
eredményeként jelenleg rendkívül széles körben illeti meg védelem ezeket a
személyeket. Ez a védelem ugyanakkor nem általános, kizárólag az adott
egészségügyi tevékenység végzéséhez kötődik, amit megerősít a rendelkezésre álló
statisztikai adatok köre is. Következtetés: Az egészségügyi
dolgozók mint közfeladatot ellátó személyek fokozott büntetőjogi védelemben
részesülnek egészségügyi tevékenységük végzése során, és ennek révén lényegesen
nagyobb mértékben tekinthetők a közfeladatot ellátó személy elleni erőszak
bűncselekménye sértettjeinek. Orv Hetil. 2023; 164(6): 227–233.
Primer szklerotizáló cholangitisben szenvedő, májtranszplantációra váró beteg sikeres várandóssága
Authors: Ozsvári-Vidákovich Magdolna , Péter Zoltán , Vilmos Fruzsina , Szijártó Attila , Dániel Ádám , Lakatos Lóránd , Ács Nándor , Sára Levente , Szakony Szilvia , Sziller István
Published: February 2023

A primer szklerotizáló cholangitis (PSC) nőkben különösen ritka, progrediáló,
cholestasissal és gyakran colitis ulcerosával járó, súlyos formájában
szervátültetést igénylő májbetegség. A teherbe esés esélyére és a várandósság
kiviselésére gyakorolt hatását hazai közlemény eddig nem elemezte. Közleményünk
célja a súlyos colitis ulcerosával és cholestasissal szövődött PSC mellett
fogant várandósság lefolyásával foglalkozó irodalom áttekintése, egy fiatal,
először várandós sikeres szülése, majd postpartum colectomiája kapcsán. A 37
éves, májátültetésre váró primigravida várandóssága spontán fogant, és súlyos
májbetegsége mellett, a gyógyszeresen kezelhető magas vérnyomás ellenére,
zavartalan lefolyású volt. A harmadik trimeszterben cholestasisa jelentősen
fokozódott, a szérum-összepesavszint 100 μmol/l fölé emelkedett, de napi 8 g
kolesztiramin adásával az érték rövid időn belül a normáltartományba csökkent.
Késői koraszülése a fekélyes vastagbélgyulladás akut fellángolása következtében
kialakult chorioamnionitis miatt indult meg. Császármetszéssel eutrófiás, jó
általános állapotú gyermek született, aki azóta is egészséges. A korai
gyermekágyban a colitis ulcerosa tovább súlyosbodott, gyógyszeres kezeléssel a
beteg szeptikus állapota nem volt kezelhető. Góctalanítás érdekében subtotalis
colectomiára került sor, amely után 12 nappal a beteg jó állapotban otthonába
került. A műtét után 3 hónappal a tehermentesítő ileostoma zárásra került. A máj
állapota miatt a gyermekágyas ismét májátültetésre vár. Esetünk az irodalmi
adatokkal egyezően arra utal, hogy a colitis ulcerosával szövődött PSC mellett
fogant várandósság – szoros belgyógyászati és szülészeti ellenőrzés mellett –
vállalható, de a bél- és a májbetegség mind a várandósság alatt, mind a
gyermekágyas időszakban progrediálhat. Kolesztiramin adása alkalmas lehet a
magas összepesavszint gyors, jelentős és biztonságos csökkentésére. Orv Hetil.
2023; 164(6): 234–240.
A „másik” inkretin – a glükózdependens insulinotrop polipeptid terápiás újrafelfedezése
Authors: Winkler Gábor , Kis János Tibor , Schandl László
Published: February 2023

Az inzulinszekréciót erélyesen serkentő, élettani szabályozásában is részt vevő
két inkretin közül a 2-es típusú diabetesben is megtartott – bár csökkent −
secretagog természete folytán hosszú időn keresztül a glükagonszerű peptid-1
(GLP1) került az érdeklődés előterébe, kívülről bejuttatott receptoragonistái
bekerültek az antidiabetikus kezelés eszköztárába is. Újabb vizsgálatok fényében
a „másik” inkretin, a glükózdependens insulinotrop polipeptid (GIP) is más
megvilágításba került. Kiderült, hogy a glükagon és az inzulintermelés
vércukorszinthez igazodó szabályozásával bifunkcionális vércukor-stabilizáló
tényezőként viselkedik 2-es típusú diabetesben is. A közlemény áttekinti a GIP
élettanával kapcsolatos új adatokat, 2-es típusú diabetesben és elhízásban
igazolható hatásait, a „twincretin” hatás, a GIP és a GLP1-receptor kettős
stimulálásának előnyeit. Ismerteti az első, már terápiás ajánlásokban is
megjelent duális receptoragonista, a tirzepatid farmakológiáját és az
alkalmazásával kapcsolatos első klinikai vizsgálatokat. A molekula az eddigi
adatok tükrében új távlatokat jelenthet a 2-es típusú diabetes és az elhízás
kezelésében. Orv Hetil. 2023; 164(6): 210–218.
Személyre szabott orvoslás és egészségügy: hol tartunk, merre menjünk?
Authors: Gulácsi László , Békássy Szabolcs , Bittner Nóra , Feith Helga Judit , Ficzere Andrea , Horváth Lajos , Horváth Zsolt , Tóth Icó , Zrubka Zsombor , Tóth Erika , Kovács L. Gábor
Published: February 2023

A szerzők az orvostudomány különböző területeiről érkeztek, tapasztalt
szakemberek. Vannak köztük gyakorló orvosok az alapellátásból és a
kórházi/klinikai ellátásból, diagnosztikai szakemberek, egészségügyi
szervezéssel, egészség-gazdaságtannal vagy betegjogokkal foglalkozó kutatók,
betegszervezetek képviselői. Közös bennük, hogy valamennyien elkötelezettek a
személyre szabott orvoslás és a személyre szabott egészségügyi ellátórendszer
bevezetése mellett. Jelen – vitaindítónak is szánt – közleményükben azt a két
téveszmét szeretnék eloszlatni, hogy a személyre szabott orvoslás ma még csak a
jövő tervezőinek kísérleti terepe, azaz még nem a való világ része, illetve hogy
a személyre szabott egészségügyi ellátórendszer hazai bevezetését csak (vagy
főképpen) anyagi okok akadályozzák. Orv Hetil. 2023; 164(6): 202–209.
Comorbid pathology issues in pediatric gynecology
Authors:   SI «Institute for Children and Adolescents Health Care of the NAMS of Ukraine», Kharkiv, Dynnik V.O. , Bagatska N.V. ,   SI «Institute for Children and Adolescents Health Care of the NAMS of Ukraine», Kharkiv, Dynnik O.O. ,   Kharkiv National Medical University of Ministry of Health of Ukraine, Verchoshanova O.G. ,   SI «Institute for Children and Adolescents Health Care of the NAMS of Ukraine», Kharkiv, Havenko H.O. ,   SI «Institute for Children and Adolescents Health Care of the NAMS of Ukraine», Kharkiv
Published: February 2023

The problems of diagnosis, therapeutic tactics and medical prognosis in comorbid, polymorbid pathology stand out among the most actual problems of modern health care. Purpose - to study the frequency and nature of comorbid conditions in patients with pubertal abnormal uterine bleeding (PAUB). Materials and methods. The study included 342 girls aged 11-17 suffering from PAUB. All patients were examined by a multidisciplinary team of doctors. Results. It has been shown that menstrual irregularities are combined with other somatic, mental and endocrine pathologies in the vast majority of patients. Only 9.6% of the patients examined had no concomitant pathologies. More than half of girls have a combination of more than three comorbidities. The first three ranks are occupied by endocrine, mental and digestive system disorders. More than a third of patients with endocrine disorders had deviations in terms of body weight - overweight and obesity, which is much more often accompanied by changes in carbohydrate and lipid metabolism. In patients with mental disorders astheno-neurotic syndrome and vegetative-vascular dystonia syndrome prevailed. Functional disorders of the biliary tract were mainly recorded among the disorders of the digestive system, about 18% of girls suffered from gastritis, cholecystitis. The presence of comorbid pathology reduced the effectiveness of non-hormonal therapy by 1.5 times and increased the number of relapses by 3.5-4 times. The effectiveness of non-hormonal therapy was 81.8% on the absence of concomitant pathology; relapses were recorded only in 16.7%. Conclusions. Comorbid pathologies in patients with PAUB aggravate the severity of the girl’s condition, reduces adaptive capabilities, adversely affects the effectiveness of non-hormonal therapy, contributes to the recurrence of the disease and is a risk factor for the development of serious metabolic, endocrine and cardiovascular diseases in the future. The category of patients with concomitant pathology requires a special examination algorithm and the appointment of an adequate therapeutic intervention, taking into account all the identified nosological forms and drug compatibility. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
To the issue of diagnosis of neuropsychological development of newborns and young children
Authors:   SI Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova of the NAMS of Ukraine, Kyiv, Shveikinа V.B. ,   National Children’s Specialized Hospital «OHMATDYT», Kyiv, Ukraine, Martyniuk V.Yu. ,   SI «Ukrainian Medical Rehabilitation Center for Children with Organic Disorders of Nervous System Ministry of Health of Ukraine», Kyiv
Published: February 2023

The current problem of neonatology and child neurology is highlighted - the features of early diagnosis of neuropsychological development of newborns and young children. The scientific literature on the morphofunctional features of brain development was analyzed, while the main attention was paid to the first two years of a child’s life. It is emphasized that the peak activity of brain development falls on the second half of pregnancy and the first three months of postnatal life. New data on the development of the brain are described, namely the presence of a transitional structure - the cortical subplate. It is shown that the development of the motor and behavioral sphere of a newborn and an infant is largely mediated by the coexistence of two separate but interconnected brain structures - the transitional structure, namely the subplate and the formation of the cortical plate during this period. It is emphasized that two age periods are important for the diagnosis of neurodevelopmental disorders: the first is about three months after birth, when the cortical subplate in the primary motor, somatosensory, and visual cortex is eliminated, and the second is the end of the first year, when the cortical subplate is eliminated in the prefrontal and parietal temporal regions. It was determined that the clinical manifestations associated with the disappearance of the subplate in the primary sensory and motor areas three months after childbirth coincide with a major transition in motor behavior, namely, spontaneously generated general movements are replaced by purposeful movements, adaptive behavior is formed in response to changes in environmental factors. Some clinical and diagnostic features in the detection of early disorders of neuropsychological development are highlighted, taking into account the stages of brain maturation (myelination, synaptogenesis). Some of the most common diagnostic scales and tests are considered. The most significant motor scales in the infant period, which are used to predict the outcome, are shown. Some standardized neurological assessments are highlighted. The concept of an early intervention program for infants with a high risk of developing cerebral palsy and cognitive impairment is defined. No conflict of interests was declared by the authors.
Congenital neutropenia in children: short and long way to diagnosis
Authors:   I. Horbachevsky Ternopil National Medical University, Ukraine, Boyarchuk O.R. , Shulhai O.M. ,   I. Horbachevsky Ternopil National Medical University, Ukraine, Dobrovolska L.I. ,   I. Horbachevsky Ternopil National Medical University, Ukraine
Published: February 2023

The diagnosis of neutropenia is based, first of all, on the results of the assessment of the absolute number of neutrophils in the complete blood count and the clinical picture. Genetic confirmation of the diagnosis of congenital neutropenia can be long and not always successful. The purpose of work - to analyze the clinical course and laboratory features of congenital neutropenia in children on bases of two clinical cases in order to pay the doctors’ attention to the diagnosis of these diseases. We present clinical cases that confirm the variability of clinical and laboratory manifestations and the severity of the course of neutropenia. In the first case, congenital neutropenia was manifested by profound clinical signs with cyclicity, was accompanied by fever, aphthous stomatitis, and gingivitis. The absolute neutrophil count was consistent with severe neutropenia, but it took several years for genetic confirmation of the diagnosis. The second case of cytopenia, including neutropenia in a boy, was found in twins by chance, as the children had no clinical manifestations associated with neutropenia. Despite the obviousness of neutropenia in the general blood test with or without clinical manifestations, the path to a complete diagnosis is not always simple. Cytopenia in children, including neutropenia, requires a multidisciplinary approach to diagnosis, excluding both the causes of secondary neutropenia, hematological pathology, and immune disorders, primarily the phagocytic defects. Genetic testing can help verify an accurate diagnosis in patients with inborn errors of immunity, however, the genetic variants of a large number of congenital neutropenias remain unknown. Isolated neutropenia in children, as well as in combination with other cytopenias, require careful monitoring and the selection of optimal management tactics, as they can have serious complications. Following of patients will make it possible to expand knowledge about the disease course, the dynamics of symptoms, the occurrence of complications in order to prevent them. The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of all participating institutions. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
Linear IgA-bullous dermatosis in a child during martial law. Clinical case
Authors:   Zaporizhzhia State Medical University, Ukraine, Nedelska S.M. ,   MNPE «City Children’s Hospital No. 5» of Zaporizhzhia City Council, Ukraine, Svyatenko T.V. ,   Dnipro State Medical University, Ukraine, Kuznetsova O.D. ,   Zaporizhzhia State Medical University, Ukraine, Pukhyr V.P. ,   Zaporizhzhia State Medical University, Ukraine
Published: February 2023

Linear IgA-bullous dermatosis (chronic childhood disease) - a rare autoimmune subepithelial vesiculobulular disease caused by the formation of IgA autoantibodies, directed against various hemidesmosomal antigens, which is more common in children of early preschool age. Purpose - is to describe our own clinical observation of a case of linear IgA-bullous dermatosis in a girl aged 2 years 9 months to increase the level of alertness of doctors regarding this pathology in children, especially at an early age. Clinical case. At the time of admission her condition was of moderate severity due to the presence of a confluent papular-vesicular rash located on the face, neck, limbs. The rash was accompanied by the development of erosions surrounded by a ring of vesicles and caused a feeling of discomfort, severe itching. During local treatment and systemic antifungal tablets, the child’s condition improved, however, complete remission was not achieved after 7 week of the therapy, new bullas appeared. Additional diagnostic investigation allowed to suppose the diagnosis linear IgA - bullous dermatosis. Adjustment of therapy was made (steroids per os administration) and the child's condition improved gradually in a month. The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies. No conflict of interests was declared by the authors.
Lymphadenopathy and worm infestation in children: the action algorithm
Authors:   I.Ya. Gorbachevsky Ternopil National Medical University, Ukraine, Nykytyuk S.O. , Tsymbalyuk I.M. ,   KNE «Ternopil Regional Children’s Clinical Hospital», Ukraine, Dorozhovska Kh.I. ,   I.Ya. Gorbachevsky Ternopil National Medical University, Ukraine, Levenets S.S. ,   I.Ya. Gorbachevsky Ternopil National Medical University, Ukraine, Voroncova T.O. ,   I.Ya. Gorbachevsky Ternopil National Medical University, Ukraine, Dollinna M.V. ,   KNE «Ternopil Regional Children’s Clinical Hospital», Ukraine
Published: February 2023

Fever is a common complaint in children with lymphadenopathy. Reactive lymphadenopathy is defined as the presence of one or more lymph nodes with a diameter of more than 1.5-2.0 cm. A thorough diagnosis of lymphadenitis accompanied by hyperthermic syndrome is necessary. Purpose - is to determine the diagnostic algorithm of actions based on the example of a clinical case of fever of unclear origin. Clinical case. The peculiarity of this case is a prolonged hyperthermic syndrome with lymphadenitis against the background of helminthic invasion (toxocarosis). During her stay in the hospital, the girl’s condition was serious due to hyperthermic syndrome and lymphadenopathy. The diagnostic algorithm for this condition in children is proposed. During the examination, a diagnosis of Reactive cervical lymphadenopathy of infectious-allergic genesis; concomitant - «Parasitic invasion is mixed (toxocariasis, ascariasis). Fever» was established. The child’s condition upon admission was severe, due to intoxication and hyperthermic syndrome. The treatment was effective, the patient’s condition improved during the hospitalization. But establishing a diagnosis required the cooperation of doctors of many specialties and a large number of additional examinations. Conclusions. Therefore, it is necessary to form the alertness of pediatricians to toxocarosis and increase the level of knowledge about the correct diagnostic algorithm in such cases. Informing health care professionals about such lymphadenopathy and helminthic infestation in children should help practitioners distinguish them from febrile reactions or other conditions and improve treatment outcomes. The research was carried out in accordance with the principles of the Declaration of Helsinki. Informed consent of the child’s parents was obtained for the research. No conflict of interests was declared by the authors.
Biomimicry as an Approach to Improve Daylighting Performance in Office Buildings in Assiut City, Egypt
Authors:   Department of Architectural Engineering, Assiut University, Assiut 71515, Egypt, Hassan Fayrouz H. F. , Ali Khaled A. Y. ,   Department of Architectural Engineering, Assiut University, Assiut 71515, Egypt, Ahmed Salwa A. M. ,   Department of Architectural Engineering, Assiut University, Assiut 71515, Egypt
Published: February 2023

Biomimicry inspired architects to solve complex design problems and develop adaptive solutions for enhancing the environmental quality. Fields of inspiration include energy efficiency, natural ventilation, daylighting, and structural stability. In this paper, 144 biomimicry-inspired building skin alternatives have been developed to improve daylighting performance in office buildings in Assiut City, Egypt; 72 alternatives are of 0.5 m frame depth, and other 72 alternatives are of 1.0 m frame depth. Two levels of biomimicry; namely, the organism level (snakeskin) and the behavior level (plants tropism), have been adopted. Alternatives have been developed to be simulated ClimateStudio plug-in for Rhino in accordance with the international rating system leadership in energy and environmental design (LEED v4.1). The evaluation criteria are spatial Daylight Autonomy (sDA), Annual Sunlight Exposure (ASE), Annual Average Lux (AAl), and Spatial Distributing Glare (sDG). An evaluation point system has been developed to evaluate alternatives using Analytical Hierarchy Process (AHP) based on the feedback of 14 faculty of architecture members. Nine building skin alternatives developed succeeded to achieve notable improvement (from 16.69% to 33.73%) compared to the base cases. In general, the 1.0 m frame-depth alternatives achieved better results in improving daylighting performance than the 0.5 m frame-depth alternatives. The most effective parameter in improving daylighting performance was the rotation angle of the skin unit used, to be followed by the distance between the skin and the building façade, the solid-to-void ratio of the skin, the number of units constituting the skin system, and the horizontal bending distance of the skin unit, respectively.
EN PRENSA. Actividad Antagónica de Pseudomonas donghuensis y Bacillus subtilis para el manejo de fitopatógenos del “Damping off. EN PRENSA
Authors: Gallegos Morales Gabriel , Jiménez-Pérez Omar , Hernández-Castillo Francisco Daniel , Espinoza-Ahumada César , Castro del Angel Epifanio , Sanchez-Yañez Juan Manuel
Published: February 2023

Se evaluó la efectividad de Pseudomonas donghuensis y de Bacillus spp., para el control de Fusarium oxysporum y Pythium aphanidermatum causantes del ahogamiento de plántulas de chile en invernadero. Se comprobó su patogenicidad para ocasionar la enfermedad y se realizaron pruebas de antagonismo en placas con PDA enriquecido. Mediante la confrontación in vitro de estos fitopatógenos con siete cepas Bacillus spp., se comprobó que este esporulado inhibió en mayor o menor grado (39.35- 56.24 %) el crecimiento micelial de F. oxysporum, pero no tuvo efecto alguno para P. aphanidermatum, ningún Bacillus spp., inhibió a este Oomycete, debido a su rápido crecimiento en la placa de cultivo (36 h de incubación). En contraste P. donghuensis inhibió en un 76 % el crecimiento de P. aphanidermatum, y no presentó efecto inhibitorio para F. oxysporum, por lo que la mezcla de ambos antagonistas pudiera tener potencial para el control de los problemas de ahogamiento (‘‘Damping off“) causados por estos fitopatógenos.
Diastolic dysfunction in late postmenopausal patients with undifferentiated connective tissue disease and hypertension
Authors: Shambatov A. M. , Izmozherova N. V. , Popov A. A. , Grishina I. F.
Published: February 2023

Aim. To assess myocardial diastolic function (DF) in late postmenopausal women with undifferentiated connective tissue disease (UCTD) and hypertension (HTN).

Material and methods. This cross-sectional study included 135 postmenopausal women, the median age of which was 68 years (65÷70,5 years). The anamnesis was collected using a standardized questionnaire. Verification of UCTD was carried out according to clinical guidelines. All patients underwent standard transthoracic echocardiography. The assessment of left ventricular (LV) DF was carried out according to the transmitral flow. LV diastolic dysfunction (DD) was classified into three types: rigid, pseudonormal, and restrictive. Statistical processing was carried out in the STATISTICA 13.0 environment. The measure of data averaging is the median, the measure of dispersion is 25%÷75%. The significance of differences was assessed using the Mann-Whitney test. Differences were considered significant at p˂0,05.

Results. Group 1 — 20 (14,8%) patients with verified UCTD and HTN, group 2 — 88 (65,2%) patients with HTN without UCTD, control group — 23 (30%) patients without HTN and UCTD. There were no differences in age, duration of postmenopause and body mass index between the groups. In the first group, a significant decrease in the ratio of peak early to late diastolic LV filling velocity was revealed (p˂0,01). A significant increase in left ventricular end-systolic wall stress revealed in group 1. In 108 (100%) patients, LVDD was detected; among the patients of the control group, DD was not detected. In 8 (40%) patients in group 1, a pseudo-normal type of DD was detected, while in 12 out of 20 patients (60%) — rigid type of DD. When assessing DF in patients of group 2, a significant decrease was found in the ratio of peak early to late diastolic LV filling velocity, a significant increase in LV end-diastolic wall stress and end-diastolic pressure. In 2 out of 3 (57,80%) patients of group 2, DD of the rigid type was detected, while pseudonormal type — in 32,2% of patients in this group. Group 2 patients had a significant decrease in the early diastolic mitral annular velocity (p˂0,01).

Conclusion. The analysis of myocardial echocardiographic characteristics indicates a significant contribution of HTN-associated UCTD to the development of LVDD in postmenopausal women.
2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure
Authors: McDonagh Th. , Metra M.
Published: February 2023

Developed by the Task Force for the diagnosis and treatment of acute and chronic heart failure of the European Society of Cardiology.(ESC) With the special contribution of the Heart Failure Association (HFA) of the ESC.
Role of brain natriuretic peptide in the pathogenesis of resistant hypertension
Authors: Nikolaev K. Yu. , Shilova A. V. , Kovaleva A. Ya. , Lifshits G. I.
Published: February 2023

Modern medicine has successfully used the N-terminal pro-brain natriuretic peptide (NT-proBNP) as a biomarker for many cardiovascular diseases (CVDs). According to a number of studies, NT-proBNP may also play a role in the development of resistant hypertension (RH), but the existing work addresses this issue only indirectly. In turn, RH causes serious damage to the economic and social spheres, worsening the quality of life of patients. Thus, the complexity of verification and treatment of RH, the inconsistency of the described associations of NT-proBNP and RH makes this topic more relevant than ever.
Changes in aortic root dimensions after ascending aortic repair with concomitant aortic valve replacement
Authors: Panfilov D. S. , Bazarbekova B. A. , Panfilova N. O. , Saushkin V. V. , Sonduev E. L. , Sazonova S. I. , Kozlov B. N.
Published: February 2023

The issue of ascending aortic repair with concomitant aortic valve replacement in pa-tients with ascending aortic aneurysm (AscAA) and aortic valve stenosis is still debatable.

Aim. To analyze the dimension changes of the preserved aortic root after simultaneous ascending aorta repair and aortic valve replacement.

Material and methods. This retrospective study included 102 patients who, from December 2012 to May 2022, underwent simultaneous aortic valve replacement and ascending aorta repair with hemiarch replacement. Patients were divided into 2 following groups based on the aortic valve morphology: group 1 — patients with bicuspid aortic valve (BAV) and AscAA (n=75), group 2 — patients with tricuspid aortic valve (TAV) and AscAA (n=27). Depending on the presence of aortic root dilatation (maximum diameter (d) >40 mm), each of the groups was additionally stratified into 2 more subgroups as follows: patients without aortic root dilatation (d≤40 mm) and patients with its dilatation (d>40 mm). The dynamics of the aortic root diameter was assessed by computed tomography angiography.

Results. The mean follow-up period for patients was 36,2±14,6 months. Survival rate in the BAV+AscAA and TAV+AscAA groups was 96% and 100%, respectively (p=0,380). Freedom from aortic root resurgery was 100% in both study groups. In patients with dilated and non-dilated aortic root of the BAV+AscAA group, an increase in aortic root dimension was noted at a rate of 0,65±0,51 mm/year and 0,32±0,27 mm/year, respectively. In patients of the TAV+AscAA group, a regression in dilated and non-dilated aortic root diameter was observed as follows: 0,93±0,48 mm/year and 0,56±0,43 mm/year, respectively.

Conclusion. In patients with AscAA in combination with BAV stenosis after a singlestep surgical intervention, a weak negative dynamics of non-dilated and dilated aortic root is observed in the mid-term follow-up period. In patients with AscAA and TAV, there is involutive alterations of the aortic root dimension during 3-year follow-up.
Dynamics of global and segmental strain as a marker of right ventricular contractility recovery in patients after COVID-19 pneumonia
Authors: Shirokov N. E. , Yaroslavskaya E. I. , Krinochkin D. V. , Osokina N. A.
Published: February 2023

Aim. To study the changes of morphological and functional right ventricular (RV) parameters depending on the severity of coronavirus infection 2019 (COVID-19) pneumonia over long-term follow-up.

Material and methods. A total of 200 patients (men, 51,5%, mean age, 51,4±10,9 years) were examined at 2 control visits (3, 12 months after receiving two negative polymerase chain reaction tests). Patients were divided into following groups: group I (n=94) — lung tissue involvement ≥50% according to inhospital chest computed tomography (chest CT), group II (n=106) — lung tissue involvement˂50% according to chest CT.

Results. The groups were comparable in key clinical and functional parameters 3 months after COVID-19 pneumonia. Speckle tracking echocardiography (STE) revealed a significant increase in following global longitudinal strain (LS) parameters: RV free wall endocardial LS (-22,7±3,2% and -24,3±3,8% in group I, p<0,001; -23,2±3,5% and -24,5±3,4% in group II, p><0,001), and RV endocardial LS (-21,0±3,1% and -22,5±3,7% in group I, p><0,001, -21,5±3,2% and -22,6±3,3% in group II, p=0,001 ). Significant increase of segmental endocardial LS was revealed in group I in the basal segments of RV free wall (-26,2±5,1% and -28,1±5,1%, p=0,004) and interventricular septum (IVS) (-16,2 [13,9; 19,5]% and -17,5 [14,6; 21,4]%, p=0,024), IVS middle segment (-20,3±4,1% and -21,5±4,8%, p=0,030), as well as in group II in the apical segments of RV free wall (-21,9±6,7% and -24,4±5,2%, p=0,001) and IVS (-23,7±4,7% and -24,9±4,8%, p=0,014). Conclusion. Recovery of RV function during a 12-month follow-up period in patients with both severe and moderate/mild lung involvement in COVID-19 was detected using the STE method.>˂0,001; -23,2±3,5% and -24,5±3,4% in group II, p˂0,001), and RV endocardial LS (-21,0±3,1% and -22,5±3,7% in group I, p˂0,001, -21,5±3,2% and -22,6±3,3% in group II, p=0,001 ). Significant increase of segmental endocardial LS was revealed in group I in the basal segments of RV free wall (-26,2±5,1% and -28,1±5,1%, p=0,004) and interventricular septum (IVS) (-16,2 [13,9; 19,5]% and -17,5 [14,6; 21,4]%, p=0,024), IVS middle segment (-20,3±4,1% and -21,5±4,8%, p=0,030), as well as in group II in the apical segments of RV free wall (-21,9±6,7% and -24,4±5,2%, p=0,001) and IVS (-23,7±4,7% and -24,9±4,8%, p=0,014).

Conclusion. Recovery of RV function during a 12-month follow-up period in patients with both severe and moderate/mild lung involvement in COVID-19 was detected using the STE method.
Comparison of the novel START vascular stiffness index with the CAVI index, assessment of their values and correlations with clinical parameters
Authors: Vasyutin I. A. , Leon K. , Safronova T. A. , Bakholdin I. B. , Barkan V. S. , Milyagin V. A. , Pronko T. P. , Talov A. V. , Tentyukov D. E. , Chulkov V. S. , Peskov K. V. , Podzolkov V. I. , Sokolov V. V.
Published: February 2023

Aim. To compare the cardio-ankle vascular index (CAVI) and the novel START vascular stiffness index and assess their values and correlations with clinical parameters.

Material and methods. This multicenter study included 928 (403 men and 525 women) randomly selected patients, aged 18 to 89 years (mean age, 41±15,8 years). Inclusion criteria were age over 18 years. There were following exclusion criteria: mental disorder, severe somatic diseases and cancer, contraindications for volume sphygmography using the Fukuda Denshi VS-1500 VaSera system, no patient consent, ankle-brachial index <1,0 and >1,3. Further, according to the main parameters obtained using volum sphygmography, a novel START index was calculated. Comparison of index values and analysis of their correlation with clinical indicators, such as age, systolic blood pressure, diastolic blood pressure, pulse pressure (PP), body mass index and heart rate (HR), were carried out using simple and multiple linear regression, dispersion analysis, calculation of the Pearson coefficient (r), in the software environment R version 4.0.2.

Results. Statistical analysis revealed a high correlation between START and CAVI indices (r=0,986, p<0,001). The values of both indices increase significantly with age (ANOVA p><0,001). Both START and CAVI correlate with all studied clinical parameters. However, in men, there was no relationship of the indices with PP and HR (p>0,05). According to multiple linear regression, the relationship between diastolic blood pressure at the age of 30-60 years and PP at the age of 18-40 years with the START index is more pronounced than with the CAVI index. However, further study of the mathematical model did not reveal a significant difference in the index values for groups with and without high blood pressure.

Conclusion. The START vascular stiffness index significantly correlates with the CAVI index, showing no significant differences from CAVI in quantitative relationships with blood pressure, body mass index, heart rate, and sex in various subgroups of the subjects.