bluuebunny/crossref_metadata_2025 huggingface dataset:
An In Vitro Comparative Study of Maxillary Denture Base Retention Between Conventional Fabrication and 3D Printed Techniques
Authors: Qadir Gasha , Abdulkareem Jwan
Published: December 2023

Objective: Many researchers have attempted to assess 3D printing as a manufacturing method to be used as an alternative for theconventional means. The current study aimed to determine the feasibility of 3D printed complete dentures in terms of retention.Methods: An edentulous maxillary model with an overlaying layer of mucosa was fabricated by 3D printing, using two different resinsfor the mucosa and model, which were then glued together to establish the final model. Afterwards, 8 single step putty and washimpressions were recorded with addition silicone. Each impression was scanned with a laboratory scanner. From each impression astone cast was fabricated on which a conventional baseplate was constructed by heat polymerized PMMA with the pack and presstechnique. Meanwhile, from the 8 STL files of the scanned impressions, 8 baseplates were designed and printed with the denture baseresin. Next, each of the 16 baseplates were connected to a loop at their center. Finally, the retentive value of all baseplates was measured by means of the universal testing machine. A statistical analysis was performed to evaluate the significance of retentive difference between the two groups.

Results: The statistical analysis revealed that the printed dentures were significantly more retentive than the conventional, with a p-value of less than 0.029 and mean values of 15.0462 N and 12.05 N respectively.

Conclusions: This study concluded that 3D printed complete dentures were significantly more retentive than the conventionallyfabricated dentures.
Methodological Foundations of The Use of Integrative Technologies in The Teaching of Biology in Academic Lyceums
Authors: Ibodova Mahfuza Namozovna
Published: December 2023

This article describes information about the use of integrative technologies in teaching biology in academic lyceums. The use of integrative technologies in teaching biology prepares the ground for the development of students' intellectual activity, the development of intelligence, and the development of a scientific worldview in the formation of competencies related to science. Case studies, trial and error, brainstorming, test tasks are formed with the aim of assessing the knowledge, skills and competencies acquired by students, scientific and technical competencies, information processing, analysis, synthesis, comparison, abstraction used in teaching biology. ideas are put forward that summing up, concluding and finding a solution to an educational problem will allow us to put forward new ideas.
Semantic changes of English Euphemisms
Authors: Hilola Ismailova Inomovna
Published: December 2023

Given article is devoted to the study of semantic changes of Euphemisms. It discusses the differences and similarities of euphemisms in all the sphere of life. Euphemisms are used to replace social taboos, swearing, blasphemy, profanity and other offensive language, but they can be used just to make a common word sound more sophisticated. For indirect expressing, stylistic means like figures of speech can be used for expressing euphemisms.

Another subject mentioned in the paper is euphemistic strategies discussed from pragmatic point of view.
The Structure of Anthroponyms and Its Functioning in English and Russian Languages
Authors: Ruxsorxon Akbarova Farxodjon qizi  , Fayzimatova Nodiraxon Adxamjon qizi
Published: December 2023

Some aspects of the functioning of anthroponyms and the conditions for the realization of their cognitive potential in Russian and English-speaking linguistic cultures. Based on the conducted research using survey and interview methods, an attempt is made to demonstrate how the mobility of the anthroponymic model allows us to reflect the idea and perception of personality in different cultures and how a person regulates relationships with the environment when assistance in choosing name forms in communication. The article deals with the functioning of anthroponyms and the conditions for the realization of their cognitive potential in the Russian and English cultural contexts.
Effect of Some Levels from Ziziphus Spina-christi Leaves and Choline on Acute Liver Disease in Rats
Authors: Ashraf Abd El-Aziz Abd El-Megeid  , Lotfia Bahr Hassan  , Ola Hassan Shafeek
Published: December 2023

The study aims to investigate the effects of diets containing two levels of Ziziphus Spina-christi leaves, choline, and their combinationson nutritional evaluation, some biochemical analysis, anda histopathological examination of the livers of rats suffering from acute liver disease. This study involved the use of forty-eight male albino rats. Rats in this study were divided into2 main groups, as follows:The 1st main group (n=6 rats) was fed a basal dietas a negative control group. The 2ndmain group (42 rats) wasinjected subcutaneously with CCl4 in paraffin oil to induce acute liver disease in rats. The second main group of rats was divided into seven subgroups, each consisting of six rats,as follows: Subgroup (1)was only fed a basal diet (B.D.) as a control positive group. Subgroups 2 and 3were given diets containing 1% and 2% choline chloride, respectively. Subgroups 4 and 5were given diets containing 5% and 7.5% Zizyphus Spina-christi, respectively.Subgroups 6 and 7 were fed diets containing the combination of choline chloride and Zizyphus Spina-christi (1% choline chloride and 5% Zizyphus Spina-christi) and (2% choline chloride and 7.5% Zizyphus Spina-christi), respectively. The results indicated that injected rats with CCl4 increased liver enzymes, including AST, ALT, and ALP, while decreasing feed intake, body weight gain%, serum protein, albumin, globulin, and antioxidant enzymes, including (catalase "CAT", superoxide dismutase ("SOD"), glutathione ("GSH"), and glutathione peroxidase ("GPx"), as compared to non-injected rats. Treating acute liver disease rats with diets containing the two levels of Ziziphus Spina-christi leaves, choline, and their combinations improved all of these parameters and the histopathological changes in the liver as compared to non-treated rats. Conclusion: Ziziphus Spina-christi leaves, choline, and their combinationscan be used to reduce the side effects of acute liver diseases.
Hitabet Ve Mesleki Uygulama Derslerinin Öğrenci Gelişimine Katkı Düzeylerinin İncelenmesi (Ondokuz Mayıs Üniversitesi İlahiyat Fakültesi Örneği)
Authors: KARA Mustafa , DAM Hasan , ERTÜRK İdris
Published: December 2023

Bu çalışmada, “Hitabet ve Mesleki Uygulama” derslerinin Ondokuz Mayıs Üniversitesi (OMÜ) İlahiyat Fakültesi öğrencilerinin gelişimlerine katkı düzeyleri incelenmektedir. Araştırmanın amacı, “Hitabet ve Mesleki Uygulama (HMU)” derslerinin öğrenci gelişimlerine katkı düzeylerini belirlemektir. Bu kapsamda araştırmanın ana problemi, bu derslerin öğrenci gelişimine katkılarının bugüne dek bilimsel bir araştırmaya konu edilmemiş olmasıdır. Bu durum, araştırmanın hem özgünlüğünü hem de önemini ortaya koymaktadır. Araştırmanın örneklemi, OMÜ İlahiyat Fakültesi 4. sınıf ve mezunlardan oluşan 393 öğrencidir. Çalışmada nicel araştırma türlerinden tarama (survey) modeli kullanılmıştır. Çalışmanın verileri araştırmacılar tarafından geliştirilen anket formu ile elde edilmiştir. Verilerin analizinde frekans analizi tekniği kullanılmıştır. Bu sonuçlar, HMU derslerinin OMÜ İlahiyat Fakültesi öğrencilerinin mesleki, kişisel ve sosyal gelişimlerine katkı sağladığını, iletişim becerilerini geliştirdiğini, sorumluluk üstlenme kabiliyetlerini artırdığını, öz güven kazanmalarına yardımcı olduğunu ve mezuniyet sonrası hedefleri açısından faydalı bilgiler içerdiğini göstermiştir.
Análisis del crecimiento y mortalidad del frailejón (Espeletia pycnophylla) en los bordes de cuencas hidrográficas en el municipio de Cumbal, Nariño, Colombia
Authors: Tipaz Cuaical Luis Eduardo , Cardona Palacio Luis Fernando
Published: December 2023

En este trabajo se evalúan los parámetros de crecimiento y mortalidad de 200 frailejones de la especie Espeletia pycnophylla, que luego se sembraron en dos tipos de borde durante seis meses (borde con ganadería y bosque). Se tuvieron en cuenta dos tamaños de siembra del frailejón: pequeña (entre 4 y 10 cm) y grande (entre 10 y 20 cm). A la mitad de los individuos de estudio se les aplicó fertilizante orgánico. El análisis muestra que la supervivencia general fue de 52 %, siendo los de tamaño grande y con fertilización los que menos mortalidad presentan. El uso de fertilizante orgánico favorece los parámetros de desarrollo (crecimiento del tallo, de la raíz y en el número de hojas); sin embargo, no se presenta una diferencia estadísticamente significativa al 95 % del nivel de confianza entre el uso de fertilizante y el tamaño del frailejón, con excepción del crecimiento de las hojas.
Factors Associated With Hospital Mortality in Acute Myocardial Infarction
Authors: Sivkov O. G.
Published: December 2023

Aim    To determine clinical and laboratory parameters associated with in-hospital mortality in patients with acute myocardial infarction and to develop a multifactorial prognostic model of in-hospital mortality.Material and methods    This was a study based on the 2019-2020 Registry of acute coronary syndrome of the Tyumen Cardiology Research Center, a branch of the Tomsk National Research Medical Center. The study included 477 patients with ST-segment elevation acute myocardial infarction (AMI), 617 patients with non-ST segment elevation AMI, and 26 patients with unspecified AMI. In-hospital mortality was 6.0 % (n=67). Clinical and laboratory parameters were assessed on the day of admission. The separation power of indicators associated with in-hospital mortality was determined using a ROC analysis. The data array of each quantitative parameter was converted into a binary variable according to the obtained cut-off thresholds, followed by creation of a multifactorial model for predicting in-hospital mortality using a stepwise analysis with backward inclusion (Wald). The null hypothesis was rejected at p<0.05.Results    The multivariate model for prediction of in-hospital mortality included age (cut-off, 72 years), OR 3.0 (95 % CI: 1.5-5.6); modified shock index (cut-off threshold, 0.87), OR 1.5 (95 % CI: 1.1-2.0); creatine phosphokinase-MB (cut-off threshold, 32.8 U / L), OR 4.1 (95 % CI: 2.2-7.7); hemoglobin (121.5 g / l), OR 1.7 (95 % CI: 1.2-2.3); leukocytes (11.5×109 / l), OR 1.9 (95 % CI: 1.3-2.6); glomerular filtration rate (60.9 ml / min), OR 1.7 (95 % CI: 1.2-2.2); left ventricular ejection fraction (42.5 %), OR 4.1 (95 % CI: 2.0-8.3); and size of myocardial asynergy (32.5 %), OR 2.6 (95 % CI: 1.4-5.0).Conclusions    Independent predictors of in-hospital mortality in AMI are age, modified shock index, creatine phosphokinase-MB, peripheral blood leukocyte count, hemoglobin concentration, left ventricular ejection fraction, size of myocardial asynergy, and glomerular filtration rate. The in-hospital mortality model had a high predictive potential: AUC 0.930 (95 % CI: 0.905-0.954; p <0.001) with a cutoff threshold of 0.15; sensitivity 0.851, and specificity 0.850.
Correlation of Serum Endocan Level With Apoptosis Indicators and Severity of Atherosclerotic Lesions of Coronary Arteries in Patients With Coronary Heart Disease
Authors: Zakharyan E. A. , Gritskevich O. Yu. , Ibragimova R. E. , Grigoriev P. E.
Published: December 2023

Aim    To study the relationship of blood serum concentration of endocan with indexes of apoptosis and clinical and instrumental characteristics of patients with ischemic heart disease (IHD).Material and methods    The study included 176 subjects (105 men and 71 women). 150 of them were diagnosed with IHD and 26 were healthy volunteers. Anthropometric measurements, coronary angiography, echocardiography, duplex ultrasound scanning of extracranial parts of the brachiocephalic arteries were performed for all patients. Concentrations of endocan (ng / ml), glucose (mmol / l), and apoptotic markers Bcl-2 (ng / ml), Bax (ng / ml), Bcl-2 / Bax, TRAIL (pg / ml), and p53 (ng / ml) were measured in blood serum. Patients were divided into groups based on their SYNTAX scores: group 1 with moderate atherosclerotic lesions of the coronary arteries (CA) (score < 22, 78 patients); group 2 with severe CA atherosclerosis (score 23-32, 37 patients); and group 3 with extremely severe CA lesions (score >33, 35 patients). The control group consisted of healthy volunteers (26 subjects). All groups were age- and sex-matched. Differences were considered statistically significant at p<0.05.Results    A correlation was found between endocan concentration and IHD severity (r=0.32, p<0.001). In group 1, the median endocan concentration was 14.57 ng / ml [8.21; 23.66], in group 2, 19.34 ng / ml [8.425; 26.645], in group 3, 32.13 ng / ml [18.2; 39.12], and in the control group, 6.92 ng / ml [4.62; 9.18]. Correlations of varying strength and significance were observed between the endocan concentration and a number of clinical and instrumental characteristics. Endocan concentrations significantly differed in groups of patients with multifocal atherosclerosis (p<0.01), angina pectoris (p<0.01), a history of myocardial infarction (p<0.001), and obesity (p<0.05) from patients without these signs. Also, a correlation was found between serum endocan concentration and apoptotic markers: TRAIL (r= -0.448, p<0.001); BCL-2 (r= -0.552, p<0.001), Bax (r= -0.519, p<0.001), Bcl-2 / Bax (r= -0.576, p<0.001) and p53 (r= -0.520, p <0.001).Conclusion    The study demonstrated a potential role of endocan as a promising biomarker for risk stratification, prognosis and therapeutic monitoring of IHD patients.
Deep intronic 9q21.11 polymorphism contributes to atopic dermatitis risk through methylation regulated expression of tight junction protein 2
Authors: Eliza Lim YY , Yie Sio Y , Say YH , Reginald K , Tim Chew F
Published: December 2023

Background: Atopic dermatitis (AD) is a chronic inflammatory itchy skin condition. Genomic- and epigenetic wide association studies provide insights into the genetic susceptibility and potential underlying disease pathogenesis. Objective: This study sought to functionally characterise an AD-associated single nucleotide polymorphism (SNP) located deep intronic of the tight junction protein 2 (TJP2) gene (9q21.11 locus), identified through a genome-wide association study (GWAS). Methods: The association between the 9q21.11 locus (rs7872806) and AD was identified through a GWAS of 956 cases and 723 controls. TJP2 expression in peripheral blood mononuclear cells (PBMCs) was assessed against the rs7872806 genotypes. Allele-specific methylation was evaluated at CpG sites 10kb up- and down-stream of the 9q21.11 locus. Effects of DNA methylation on TJP2 expression was validated via in vitro methylation and 5-aza-2’-deoxycytidine-induced transcriptional activation studies. Trans-epidermal water loss measurements were used to determine skin barrier function. Results: The major allele of rs7872806 was determined to increase AD risk by 2.64-fold (adjusted p-value=2.40 x 10-18, OR=0.38), associated with increased methylation levels at cg13920460 site (p<0.001) and lower TJP2 expression in PBMCs (Pearson’s p=1.09 x 10-6, Pearson’s R=-0.313, p<0.001). Methylation inhibition by 5-aza-2’-deoxycytidine increased TJP2 promoter activity by up to 85%. Elimination of the cg13920460 methylation site increased expression by approximately 25%. The rs7872806 major allele was also found to be associated with increased trans-epidermal water loss (p<0.001). Conclusion: Epigenetic influence at CpG site cg13920460 is associated with rs7872806 located deep intronic at 9q21.11. The SNP confers susceptibility to AD through altering TJP2 expression and promoting trans-epidermal water loss.
DESIGN FEATURES OF THE ENVIRONMENT OF EDUCATIONAL INSTITUTIONS
Authors: Tsoi Mykola , Kosarevska Raddamila , Kokhan Natalia , Kapran Oksana
Published: December 2023

The article focuses on elucidating the distinctive aspects of designing the environment within educational institutions. It identifies the typical characteristics of design found in domestic higher education institutions, encompassing architectural solutions and functional concepts, as well as principles governing the division of educational spaces and zones. The article also examines the influence of classroom design on academic performance effectiveness. Notable illustrations of contemporary design within the educational environment of Ukrainian higher education institutions are presented. Additionally, the article explores design and architectural solutions employed in educational institutions abroad. Furthermore, the article puts forth original approaches toward shaping a modern design framework for educational institutions' environments. This research aims to uncover the specific characteristics associated with the design of educational institution environments. The object of investigation is the educational institution itself, viewed as a subject for design and architectural solutions. Research methods. The research employed various methods including description, analysis and synthesis, comparison, generalization, and modeling. The article delves into the distinct features associated with the design of educational institution environments. It identifies the defining characteristics of design within Ukrainian higher education institutions, explores the rationale behind such design approaches, and examines the evolution of design in the modern era. The study establishes the key aspects related to the design of specific educational spaces such as study rooms, lecture halls, specialized discipline offices, and computer rooms within Ukrainian higher education institutions (hereinafter HEIs). Additionally, recreational areas are characterized as a unique type of educational space, providing students with an opportunity to rest during breaks and prepare for upcoming classes. The study presents an analysis of the merits and drawbacks of the design of educational environments in contemporary domestic higher education institutions. It discerns the distinctive attributes within each category and assesses their influence on students' academic performance. Moreover, the study emphasizes the emerging trends that should be pursued in the development of modern HEIs design. The article uncovers the distinctive characteristics of designing educational institutions both in Ukraine and abroad. It emphasizes the particulars of designing lecture halls, study rooms, specialized rooms, and laboratories. Building upon the obtained results, this research develops approaches and principles for shaping the design of educational institution environments in Ukraine.
HARMONISATION OF THE EUROPEAN EDUCATION AREA
Authors: Bykovska Olena , Boyko Angela , Stepanova Nataliia , Karychkovskyi Vasyl , Bykovskyi Timur
Published: December 2023

Objective. The purpose of this article is to study the impact of science and education on the efficiency of social production and quality of life in the context of global integration processes. Methods. The methods used in the study are literature review, statistical data analysis, and empirical research. To obtain the results, we analysed data on the quality of education and research in Ukraine and other European countries. Results. The study found that the quality of education and research is crucial for the competitiveness of society in the context of globalisation and rapid changes in the economy and technology. Scientific achievements and educational standards are key indicators of a state's readiness to meet the challenges of the present and its ability to attract investment, attract talented young people, and ensure sustainable economic dynamics. Conclusions. The obtained results emphasise the critical role of education and research in the process of achieving sustainable development of society. The need for targeted improvement of education and support for research is recognised as a key factor in achieving a high quality of life, competitiveness, and prosperity of the country. Prospects. Future research could expand the understanding of the interaction between education, science, and the economy in a globally competitive environment. The impact of digital transformation on educational and scientific processes should also be investigated, and practical models of cooperation between universities and the private sector should be developed to stimulate innovation and societal development.
PHRASEOLOGICAL UNITS IN MODERN LINGUISTICS
Authors: Veresh Mariya , Demianenko Nataliia , Rud Olha , Bytsko Natalia , Nastenko Svitlana
Published: December 2023

The development of speech culture and communication processes has been influenced significantly by the evolution of communication itself, marked by the incorporation of stable expressions, phrases, and fixed lexical combinations. This transformation has entailed a reevaluation of content and the author's intended message, particularly within the domain of phraseological units. A pivotal area of inquiry within contemporary linguistics involves the assessment of the quality of phraseological unit usage, the delineation of classification approaches, and the formulation of systematization methods tailored to the stylistic and contextual attributes of these linguistic constructs. This article undertakes an examination of the structural components inherent to phraseological units in modern linguistics. Furthermore, it investigates the intricacies of their semantic structure, their contextual utility, and their applications across diverse modes of communication. The article comprehensively considers the intricacies surrounding the evolution of language and the concurrent emergence of new phraseological units. It also addresses the influence of scientific and technological progress, which contributes to the development of novel forms and categories of phraseological units. The distinctiveness in the formation of phraseological units within various language groups can be attributed to a combination of factors, including folk traditions, the written cultural legacy, the creative endeavours of the populace, and the transformation of cultural paradigms. Furthermore, the article emphasizes the significance of systematizing phraseological units, with an emphasis on achieving a qualitative categorization of the most prevalent lexical constructions within the respective language groups under consideration. This article undertakes an in-depth examination of the mechanisms responsible for the generation of phraseological units, as well as the distinctive characteristics in comparing such units across diverse language groups. It also incorporates a comprehensive semantic analysis aimed at elucidating the content and avenues for reinterpretation inherent to phraseological units.
A STUDY TO ANALYSE THE QUALITY OF PROBLEMS POSED BY PRE-SERVICE MATHEMATICS TEACHERS ON SQUARE ROOT EXPRESSIONS
Authors: Mersin Nazan , Karabörk Mehmet Akif , Gedik Altun Solmaz Damla
Published: December 2023

In this study, it was aimed to examine the problems that the pre-service mathematics teachers posed about the square root expressions. 35 pre-service teachers studying in the third grade of the middle school mathematics teaching department of a state university participated in this study in which the case study method was used. Each pre-service teacher was asked to pose 2 free problems related to the square root expressions. The collected data were analyzed according to the framework created by the researcher in line with the literature. Accordingly, the problems that the pre-service mathematics teachers posed were examined in terms of mathematically, data quality, grammar and expression, instructions and amount of data in the problems, solvability and overall assessment (availability). As a result, it was seen that pre-service teachers generally set up problems involving daily life, more than half of the problems they set up were solvable, but there were also problems that could not be solved due to logic errors, conceptual errors and lack of mathematical instructions.  In addition, although there were errors in terms of language and expression in the problems, the majority of the pre-service teachers used language and expression at an adequate level.
SOCIAL PROFILES OF TURKISH CHILDREN AND YOUTH LITERATURE AUTHORS
Authors: Çemçem Fatih , Lap Nazmiye Didem , Karagöz Beytullah
Published: December 2023

When examined the national and international literature, there are very few studies on the social profiles of the artists working in the fields of children and youth literature. The scarcity of existing studies in the field in terms of quantity has been the starting point for this study. In this study, the profiles of 577 authors in Hasan Latif Sarıyüce's encyclopedia of Turkish children's and youth literature were examined in terms of gender, date and place of birth, educational status, father's profession, own profession, literary genre, the number of awards they received, and foreign expansion variables. The study was qualitative, and the data were analyzed using content analysis technique. According to the results obtained in the study, it is evident that the number of authors who wrote works in the field increased after the Republic period. The gender role of most authors was male. The artists were mainly born in the western provinces of Turkey. The fathers of the artists were mostly soldiers, teachers, and members of parliament. When the professions of the artists are examined, it is seen that they are mostly teachers, authors, and civil servants. It has been seen that artists mostly produce poems, stories, and novels. Few artists in the field have received awards. The number of authors whose works have been translated into foreign languages is also very low. Some suggestions are presented based on the findings obtained from the study.
Challenges in Life Cycle Assessment and Carbon Footprint of Hydrogen
Authors: Shirinkina E.S. , Ilinykh G.V. , Mozzhegorova Yu.V. , Korotaev V.N.
Published: December 2023

An analysis of existing methodological approaches to assessing the life cycle of hydrogen was carried out to determine the level of impact of hydrogen technologies on the environment, including an assessment of their carbon footprint. The features of determining the boundaries of the system, functional unit and other aspects of life cycle assessment are presented. Taking into account the specifics of the fuel and energy complex of the Russian Federation, the carbon footprint of hydrogen was assessed using 5 technologies: steam reforming of natural gas (methane), water electrolysis, gasification of coal and biomass, methane pyrolysis. The results indicate the fundamental importance of the method of electricity production in the comparative assessment of hydrogen production technologies.
Microwave-Assisted Fabrication of Pd, Co and Ni Nanoparticles Modified-SiO2; as Catalysts in the Reduction Reaction of Organic Pollutants
Authors: ÇAĞLAR YAVUZ Sevtap , YAVUZ Emre , DAYAN Serkan
Published: December 2023

Nanomaterials have been used in catalytic degradation of organic pollutants also act as catalysts in for many years. Due to excellent catalytic performances of metal-based nanoparticles, these materials have been used extensively in various hybrid catalyst synthesis. The main subject of this study, heterogeneous catalysis is a low cost and multi-purpose process for many pollutants. Catalytic degradation of organic pollutants such as; 2-Nitrophenol, Quinolin Yellow and Rhodamine B was investigated by using Ni, Co, Pd nanoparticles modified SiO2 based nanomaterials. The co-doping effect on the prepared nanomaterials has been investigated with different characterization methods in terms of structural and morphological features: scanning electron microscopy, UV/Vis absorption spectroscopy, energy-dispersive X-ray spectroscopy and foruier-transform infrared spectroscopy. The highest catalytic reduction efficiencies (97.6% and 97.5%) for 2-nitrophenol and Rhodamine B was obtained by Pd-PEG-AP@SiO2 respectively. The synthesized Co-PEG-AP@SiO2 illustrated higher catalytic reduction efficiency for Quinolin Yellow (70.1%) at the end of 60s. The prepared M-PEG-AP@SiO2 nanomaterial (M: Pd,Co,Ni) can be able to utilized degradation of organic contaminants effectively.
ANALYSIS OF THE PHARMACEUTICAL MARKET FOR HERBAL SEDATIVE DRUGS
Authors: Afanasyeva Tatiana Gavrilovna , Kushnir Alena Yurievna
Published: December 2023

In the conditions of the metropolis, due to the current difficult economic situation in the country, alarming conditions are widespread among the population. On average, roughly a third of neurological patients are thought to have anxiety. Phytotherapy is one of the safest and most common treatment options.
CLINICAL AND DIAGNOSTIC ASPECTS OF NEONATAL HYPOGLYCEMIA: LITERATURE REVIEW
Authors: Ippolitova Lyudmila Ivanovna , Korotaeva Natalia Vladimirovna , Pershina Elena Sergeevna , Lobanova Olga Ivanovna , Korobeinikov Valery Borisovich
Published: December 2023

The most common metabolic pathology in the world, according to WHO, is a violation of carbohydrate metabolism. Hypoglycemia in the neonatal period is one of the most common pathologies in neonatological practice. According to data from the literature - 50% of healthy newborns who were born for the first time 8-12 hours of life cannot maintain a "hungry" level of glucose in the blood plasma. In addition, the trend towards increased risks of neonatal hypoglycemia is growing every year.
Metabolic effects of Mexidol therapy for complicated purulent-inflammatory diseases
Authors: Zemskova Veronika A.
Published: December 2023

In patients suffering from various variants of purulent-inflammatory diseases (GVZ), changes in the parameters of the immuno-metabolic spectrum are formed, which have diagnostic significance and require the appointment of certain therapy regimens. Basic treatment of diseases causes unstable positive dynamics of these indicators, which requires correction by additional prescription of the metabolite Mexidol to patients. Statistical processing of primary data indicates that laboratory spectrum indicators have correlations with immunological and metabolic indicators. This serves as confirmation of the unity of the mechanisms for the formation of antioxidant stress.
THE REALITIES OF PREVENTING VITAMIN D DEFICIENCY IN PRESCHOOL CHILDREN IN VORONEZH
Authors: Moshurova Larisa V. , Ivanova Anna A.
Published: December 2023

Vitamin D deficiency is of particular importance, because hypovitaminosis is observed in almost half of the world's population. Vitamin D has an effect on many organs and tissues, ensures the proper functioning of the body, preventing the occurrence of pathological processes due to numerous metabolic pathways. The article analyzes the prevention of vitamin D deficiency in preschool children in Voronezh at the present stage. The aim of the work was to analyze the level of awareness of parents about the functions of vitamin D, the need to prevent hypovitaminosis D to prevent the development of many diseases. The data obtained dictate the need to increase the level of knowledge of medical personnel and active work of preventive orientation by pediatricians and specialized outpatient specialists on vitamin D deficiency in children.
FEATURES OF CLINICAL MANIFESTATIONS OF COVID-19 IN CHILDREN OF THE FIRST YEAR OF LIFE
Authors: Kokoreva Svetlana P. , Kotlova Veronika B. , Razuvaev Oleg A.
Published: December 2023

During the 3 years of the COVID-19 pandemic, the proportion of children, including children of the first year of life, increased in the structure of cases. The aim of the study is to study the features of COVID-19 in children of the first year of life during the period of active involvement of children of this age in the epidemic process. The article presents a comparative analysis of the clinical and laboratory features of COVID-19 in two observation groups: 49 children aged 1 month to one year and 61 children aged one to 10 years. Clinical symptoms of COVID-19 in infants in most cases are characterized by moderate catarrhal manifestations, normal or subfebrile temperature, absence of clinical signs of lower respiratory tract lesions and respiratory failure. According to CT scans of the chest organs, almost half of the children have lung tissue damage (mainly CT-1). According to the results of laboratory examination, the majority of patients (51-82%) have an increase and long-term preservation of pathological parameters of intracellular enzymes (ASAT, CPK, especially LDH) up to 2-3 norms, blood lactate, D-dimer. Thus, there is a discrepancy between the clinical manifestations of the disease and the detected laboratory parameters.
ASSESSMENT OF POTENTIAL RISK FACTORS FOR THE DEVELOPMENT OF BRONCHOPULMONARY DYSPLASIA IN DEEPLY PREMATURE CHILDREN
Authors: Pershina Elena S. , Korotaeva Natalia V. , Ippolitova Lyudmila I. , Ponomareva Viktoria O.
Published: December 2023

Bronchopulmonary dysplasia (BPD) is one of the diseases that seriously affect the survival and prognosis of premature babies, as it can cause long-term decline in lung function and inhibit the development of the nervous system. Only according to official data, the incidence of this disease in very premature babies can be up to 21%. Currently, the only option for neonatologists to manage this condition is up-to-date assessment and alertness to potential risk factors.
ROLE OF IL-6 AND FERRITIN IN THE DEVELOPMENT OF IMMUNE RESPONSE IN THE MODERATE COURSE OF THE NOVEL CORONAVIRUS INFECTION
Authors: Kostenko Stanislav M. , Tulinova Irina A. , Zemskov Andrey M. , Khamburov Vladimir V. , Mukha Tatiana A. , Kostenko Dmitriy S.
Published: December 2023

In 2020-2022, the pandemic of the novel coronavirus infection became the main medical, economic, and political concern in the world. Disregulated immune system, unbalanced cytokine production is one of the distinctive characteristics of SARS-CoV-2 influence on human organism. Immunological aspects of the infection are still understudied. The main prognostic biomarkers of the novel coronavirus infection course are Interleukin 6 and ferritin. Their role in the development of antiviral response is so far unclear. Thus, further studies of clinical, pathophysiological and immunological developmental variants of the novel coronavirus infection are currently important.
INTESTINAL MICROBIOME. EPILEPSY AND THE POSSIBILITY OF EXPANDING ALTERNATIVE THERAPIES
Authors: Bogdanova Natalia M. , Kravtsova Kira A.
Published: December 2023

The development of sequencing technology indicates a key regulatory role for the gut microbiota in several neurological disorders, including epilepsy. The microbiota-gut-brain axis refers to the bi-directional communication between the gut and the brain and regulates gut and central nervous system homeostasis through neural networks, neuroendocrine, immune and inflammatory pathways. The present review discusses the relationship between the gut microbiota and epilepsy, possible pathogenic mechanisms of epilepsy in terms of the microbiota-gut-brain axis, and alternative therapies targeting the gut microbiota. A better understanding of the role of the microbiota in the gutbrain axis will help investigate the mechanism, diagnosis, prognosis, and treatment of intractable epilepsy.
Differentiated choice of therapy regimen for acute poisoning with topical decongestants in children using a medical decision support system
Authors: Karpushkina Ekaterina S.
Published: December 2023

Introduction. Acute poisoning in children is a major public health issue worldwide. Clinical Decision Support System (CDSS) is designed to improve quality of medical care by integrating scientific knowledge and research with information technology.

Aim. Analyze clinical features of poisoning, identify unintentional differences in drug therapy and create a CDSS for individual choice of therapy for acute poisoning in children.

Materials and methods. This study includes 178 children hospitalized with acute drug poisoning in Voronezh Regional Children's Clinical Hospital No. 1 from 2016 to 2022. The CDSS for poisoning with topical decongestants includes an algorithm for determination of the case severity depending on the patient's complaints, state of the central nervous system, cardiovascular system, and autonomic nervous system.

Results. Most frequently poisoning in young children (under 5 years old) was caused by topical decongestants - 31 people (17.1%). After implementation of information technologies there was a significant decrease from 87.5% to 62.5% in the frequency of prescription of laboratory tests and infusion therapy in young children (p0.05). Decrease of glucocorticosteroid therapy in young children from 50% to 12.5% (p0,05).

Conclusion. Information technologies implemented in the form of CDSS make it possible to carry out diagnosis and take therapeutic measures with consideration to individual features of the patient, reduce frequency of laboratory tests and drug load.
Study of the analgesic activity of new partially hydrogenated pyridines, α-cyanothioacetamide derivatives in the pharmacological tail heat immersion test on white rats
Authors: Bocheva Anastasia A. , Bibik Elena Yu. , Krivokolysko Sergey G.
Published: December 2023

Experimental study of pain helps to understand its mechanisms, features and physiological manifestations, which is essential for physiology, practical biomedicine and pharmacology.

The new derivatives of di- and tetrahydropyridines synthesized in the research laboratory "Chemex" on the basis of Lugansk State University named after Vladimir Dahl were subjected to virtual bioscreening using the Swiss Target Prediction software package. Biological screening conducted in vivo, in a thermal tail immersion test on white rats, for new, partially hydrogenated pyridines, derivatives of -cyanothioacetamide, showed the presence of the most pronounced analgesic activity (with intra-gastric using at a dose of 5 mg / kg of body weight of a laboratory animal) in four compounds with laboratory ciphers cv-091, cv-095, cv-099, cv-142.
CLINICAL CASE OF CARDIORESPIRATORY MONITORING TO CONTROL SUPPLEMENTAL OXYGEN THERAPY IN PREMATURE INFANT
Authors: Trapeznikova Anna Yu. , Ivanov Dmitry O.
Published: December 2023

One of the most common respiratory pathologies in infants born prematurely is bronchopulmonary dysplasia (BPD). Pulmonary hypertension is considered a formidable and difficult to diagnose complication of BPD. Maintaining the proper level of oxygen saturation is an integral part of nursing such patients. To diagnose respiratory pauses and episodes of desaturation during sleep, children undergo cardiorespiratory monitoring (KRM) aimed at recording episodes of apnea and hypopnea. The article discusses a clinical case of cardiorespiratory monitoring during sleep in a hospital and outpatient setting to monitor additional oxygen therapy in a premature baby suffering from bronchopulmonary dysplasia and BPD-associated pulmonary hypertension.
ANALYSIS OF RISK FACTORS AND MORBIDITY IN PREMATURE CHILDREN WITH VERY LOW AND EXTREMELY LOW BODY WEIGHT
Authors: Korotaeva Natalia V. , Ippolitova Lyudmila I. , Volkova Elena N.
Published: December 2023

Introduction. Currently, one of the leading problems in neonatology and obstetrics is premature birth, which requires high economic and social costs. Children born prematurely require long-term intensive therapy and various other advanced treatment methods, for which significant financial and human resources must be allocated. The consequences of premature birth will be clinically manifested throughout all age periods (in infancy, adolescence and adulthood). Currently, a sufficient amount of data has been accumulated confirming the fact that children born prematurely are most committed to various respiratory diseases, hypertension, type 2 diabetes and other chronic diseases.
Use of Alginate Polymer Polysaccharide Hemostatic Hydrogel
in the Treatment of Simulated Bleeding Stomach Defects
Authors: Cherednikov Evgeniy Fedorovich , Баранников Sergey Viktorovich , Yuzefovich Igor Sergeevich , Chernykh Aleksandr Vasilevich , Banin Igor Nikolaevich , Deryaeva Olga Gennadievna , Shkurina Irina Alexandrovna
Published: December 2023

The aim of the study was to develop in vivo technique and study the potential of alginate polymer polysaccharide hemostatic hydrogel application in the treatment of experimental bleeding stomach ulcers.Materials and methods. The in vivo experiment was conducted in the Laboratory of Experimental Surgery, the Research Institute of Experimental Biology and Medicine, N.N. Burdenko Voronezh State Medical University. Twelve healthy laboratory animals (dog) weighed 7-10.5 kg were selected for the study. Each animal was exposed to two bleeding stomach defects: one of which was experimental, and the other was control. Bleeding arrest in the experimental group of animals was carried out by insufflation of powdered alginate polymer polysaccharide hemostatic for a bleeding defect (Patent RF №2762120). Control stomach defects were not subjected to endoscopic treatment. The results of the experimental study were evaluated according to the following parameters: the time of experimental bleeding arrest, the presence of repeated bleeding, the timing and quality of healing simulated defects.Results. Experimental studies have demonstrated that the alginate polymer polysaccharide hemostatic hydrogel applied in the endoscopic treatment of simulated bleeding stomach defects can significantly (P=0.000001) reduce the time of experimental bleeding, from 26.5(25.3-32.0) sec to 6.0(4.0-8.0) sec, and helps to reduce the regeneration time of experimental defects from 14.5(13.5-16.5) days up to 8.0(7.5-8.5) days (P=0.000001), while improving the quality of their healing.Conclusion. Thus, the use of alginate polymer polysaccharide hemostatic hydrogel is an effective method of treating simulated bleeding stomach defects.
A Clinical Case of an Extrapulmonary form of Generalized Sarcoidosis
in the Practice of a Surgeon
Authors: Tarasenko Sergey Vasilyevich , Zhuchkova Uliana Vladimirovna , Glukhovets Ilya В.
Published: December 2023

The aim of the study is to present a clinical case of generalized sarcoidosis with no involvement of the lungs and intrathoracic lymph nodes.Materials of the study. The literature and data of clinical observation, surgical treatment and results of autopsy of a patient with generalized sarcoidosis were analyzed.Results. In this article the authors would like to draw attention to the case of generalized sarcoidosis with no lesions of the lungs and intrathoracic lymph nodes, which is 5% in the structure of morbidity, and present the clinical case of patient A., who was hospitalized in the surgical department of the Emergency Hospital. The patient was admitted with suspicion of urgent surgical pathology with extrapulmonary manifestations of the disease (polyserositis) and granulomatous lesions of the parietal and visceral peritoneum, extrapulmonary pleura, characteristic of sarcoidosis, and peritonitis, progression and development of a rare clinical form of this disease, neurosarcoidosis, which also amounts to no more than 10 % of all cases of this disease.Conclusions. This clinical case could draw the attention of specialists to this multisystem disease and the need for a multidisciplinary approach to treatment and diagnosis, which may be difficult due to the absence of typical manifestations of this pathology, as in the presented clinical case. The team of authors hopes that our experience will be interesting and will allow residents to avoid diagnostic and tactical errors in the management of such patients, since we have encountered a truly unusual and rare manifestation and complication of sarcoidosis in a patient, who ended up not in a specialized therapeutic or pulmonological department, but in surgical department of a multidisciplinary hospital.
EFFECTIVENESS OF TREATMENT OF CHRONIC GENERALIZED PERIODONTITIS USING PHOTODYNAMIC AND ANTI-INFLAMMATORY THERAPY
Authors: Khubaeva Fatima S. , Garazha Sergey N. , Grishilova Elena N. , Nekrasova Elizaveta F. , Ilyina Ekaterina E.
Published: December 2023

Inflammatory periodontal diseases remain an unsolved problem of modern medicine due to the high prevalence and insufficient effectiveness of treatment. The study examined the effectiveness of photodynamic and anti-inflammatory therapy in the treatment of chronic generalized periodontitis of moderate severity. The study material was the results of a comprehensive dental examination and treatment of 90 patients aged 30 to 49 years. For treatment, Asepta balm, photodynamic therapy (FotoSan 630 device), etoricoxib (Arcoxia) were used for follow-up periods of up to six months using periodontal indices. The high efficiency of treatment of chronic generalized periodontitis of moderate severity with a combination of photodynamic and anti-inflammatory therapy has been proven. This combination increased the effectiveness of treatment, compared with single-component antimicrobial therapy by 29.9%.
RESPONSE OF PARODONTAL TISSUES TO THE USE OF METAL-CERAMIC DENTURES WITH DIFFERENT TOPOGRAPHY OF THE GINGIVE EDGE OF CROWNS
Authors: Garazha Sergey N. , Kodzhakova Tanzila Sh , Gerbekova Julduz T. , Grishilova Elena N. , Gotlieb Angelina O.
Published: December 2023

Clinical, radiological and cytoenzymochemical studies of the results of using 243 metal-ceramic crowns during the year in 90 patients with healthy periodontium were carried out. The edges of the crowns were located in an equal number of teeth subgingivally and supragingivally. The activity of myeloperoxidase, alkaline phosphatase and cationic proteins in peripheral blood leukocytes was studied. It has been established that the subgingival location of the edge of the crowns causes the activation of the lysosomal apparatus of neutrophilic leukocytes and leads to the development of an inflammatory process in the marginal part of the gum. With the supragingival location of the edge of the crowns, there were no manifestations of the inflammatory process in the gingival margin. Changes in the biological activity of neutrophilic leukocytes precede the clinical manifestations of inflammation. Of the cytochemical parameters used in the study, the highest sensitivity was obtained when assessing the amount of cationic proteins in leukocytes.
X-RAY ASSESSMENT OF THE OROANTRAL COMMUNICATION POTENTIAL RISK IN PATIENTS DEPENDING ON GENDER
Authors: Zhidkov Roman A. , Tsitsiashvili Aleksandr M. , Vasiliev Yuri L. , Panin Andrey M. , Lezhnev Dmitry A.
Published: December 2023

Tooth extraction is the most common operation in the practice of a dentist-surgeon. With the increase in the number of surgical interventions, the number of complications also increases, one of which is the occurrence of an oroantral communication with the maxillary sinus. Knowing the causes and patterns of the prevalence of potential risk factors can significantly reduce the number of complications. Thus, the need to diagnose the presence of a potential risk of an oroantral communication formation comes to the fore. Cone beam computed tomography is the most informative and accessible method of radiodiagnosis of the relative position of the upper jaw teeth roots and maxillary sinus. This article presents the results of a study of the dependence of potential anatomical risk factors on the patient's gender according to cone-beam computed tomography.