bluuebunny/crossref_metadata_2025 huggingface dataset:
ESG strategies to deal with COVID-19 in a Brazilian public research company
Authors: Jesus Igor Rosa Dias de , Nascimento Petula Ponciano
Published: May 2021

Goal: The  paper  aims  to describe and discuss some practices and strategies that have been taken place in Embrapa Soils – a public research company that develops research in soil science – in order to deal with COVID-19 effects during the year of 2020.

 

Design / Methodology / Approach: We have chosen the ESG approach – Environmental, Social and Governance – as a theoretical background to analyze the strategies and practice we bring up on this paper. Information we have used were collected from internal management systems.

 

Results:  Results show that the company have found many strategies to deal with COVID-19 in the three aspects of ESG. Positive results company have reached rely on leadership, processes adaptation and the strength of personal and professional connections among the employees.

 

Limitations  of  the  investigation: Strategies and practices we present are limited to the scope of one singular company. ESG is a methodology that we have used a posteriori to contextualize and analyze the situation.

 

Practical  implications: Learning and reinforcing the ESG approach have been an important tool for the company to think about itself beyond the boundaries of financial approaches. It has the potential to spread to other companies or public agencies that does not profit directly from its activities.

 

Originality  /  Value:  Sharing strategies and practices companies have used to deal with covid-19 is important as a benchmarking activity for other companies as well as it makes a remarkable narrative of management in uncertain times that can be useful for present and future generations.
Foreword
Authors: Schaffner Sabina
Published: May 2021

I was very happy to accept the request to write a foreword to this
publication. This collection of case studies is special for several reasons.
Firstly, because of the geographical and institutional diversity of the
authors, bringing together experiences of teaching under COVID-19
restrictions in the university language classroom from 18 countries and five
continents. Secondly, the publication is interesting because of the variety
of case studies that testify to different strategies and emphases in dealing
with pandemic-related challenges. Finally, the case studies collected
strikingly demonstrate the creative responses of language teachers in a
variety of contexts to meet the challenges of the pandemic crisis.
Creating communities of practice: The Harvard Language Center’s role in
supporting language instruction during the pandemic
Authors: Ross Andrew F. , Axelrod Sarah Luehrman
Published: May 2021

When Harvard University moved all instruction into an online modality in
response to the COVID-19 pandemic, The Language Center positioned itself as
a critical source of guidance on best practices in this new environment. For
Harvard, an institution that has always prioritized face-to-face instruction
above all other formats, 2020 has been a watershed moment that has forced
faculty to reconsider nearly everything about the way they organize and
deliver their courses. Owing to the pandemic crisis, we find ourselves in a
moment in which the efficacy of these modalities in language learning is,
despite initial concerns, being proven day after day. In the context of this
crisis, The Language Center has developed training and support mechanisms
for this transition, focusing on desired learning outcomes, centering
instructor and student experience, and positioning the language faculty to
be able to successfully employ hybrid and online approaches to instruction
that will continue to serve them well after the crisis abates. This
contribution describes the strategies and actions that The Language Center
took to ensure the success of the remote teaching and learning of languages
at Harvard University in the first term of the 2020-2021 academic year,
after the emergency evacuation of campus in March of 2020, and offers a
model for other centers engaged in academic support. While extensive
insights on the success of these efforts are still pending, given the timing
of this crisis and the interventions undertaken, early feedback suggests
that faculty have found provided resources to be useful, and their intention
is to adopt aspects of technologically-mediated instruction in their
face-to-face teaching going forward.
Tele-mentoring using augmented reality technology in healthcare: A systematic review
Authors: Bui Dung Trung , Barnett Tony , Hoang Ha T. , Chinthammit Winyu
Published: May 2021

This systematic review aimed to identify how tele-mentoring systems that incorporate augmented reality (AR) technology are being used in healthcare environments. A total of 12 electronic bibliographic databases were searched using the terms “augmented reality”, “tele-mentoring” and “health”. The PRISMA checklist was used as a guide for reporting. The mixed method appraisal tool was used to assess the quality of the included experiments. The data were then analysed using a concept-centric approach and categorised primarily with regards to system performance and task performance measures. A total of 11 randomised controlled trials and 14 non-randomised designs were included for review. Both mentees and mentors assessed the system and task performance according to 25 categories. The feedback of mentees using AR tele-mentoring systems was generally positive. The majority of experiments revealed that the AR system was an effective tele-mentoring device overall and resulted in the effective performance of a procedure. Benefits included improvements in trainees’ confidence, task completion time and reductions in task errors and shifts in focus. However, the systems had limitations, including heaviness of the equipment, inconvenience, discomfort and distraction of wearing devices, limited battery life, the latency of video and audio signals and limited field of view.
 
Implications for practice or policy:

Health practitioners can apply AR technology to receive and follow real-time annotated instructions verbally and visually from remote experts.
Technical developers may consider improving AR devices in terms of lighter weight, larger field of view, more ergonomic design, more stable network connection and longer battery life.
Further AR-related experiments may need to explore AR tele-mentoring systems’ utility across healthcare environments with larger samples, real patient populations in remote settings, cost-benefit analysis and impacts on short- and long-term patient outcomes.
Influência de espécies exóticas invasoras na regeneração natural de um fragmento florestal urbano
Authors: Zaninello Miyamura Fernanda , Manfra Rodrigo , Daher Correa Franco Geraldo Antonio , Esteves Rejane , Pereira Muniz de Souza Silvana Cristina , Macedo Ivanauskas Natália
Published: May 2021

As espécies exóticas invasoras ameaçam a manutenção da biodiversidade, pois podem ocupar o espaço das nativas e dominar grandes extensões. O objetivo deste estudo foi avaliar a regeneração secundária no Parque Estadual Alberto Löfgren, São Paulo – SP, e a influência das espécies exóticas invasoras na sucessão. Foram instaladas 22 parcelas de 100 m² e, em cada uma, 10 subparcelas de 1 m² para amostragem do estrato regenerante. Foram coletados dados dos indivíduos de altura maior ou igual a 20 cm e diâmetro na altura do solo menor que 5 cm. Os indivíduos amostrados foram distribuídos em grupos funcionais de polinização, dispersão e sucessão. Foram registrados 1.150 indivíduos, distribuídos em 93 espécies (21% exóticas), 86 gêneros e 48 famílias. A maior parte das espécies são polinizadas (84%) e dispersas (61%) por animais. Apesar do estrato regenerante apresentar grupos funcionais compatíveis com a trajetória sucessional progressiva, o destaque das exóticas nos parâmetros fitossociológicos foi expressivo, o que evidencia competição com a regeneração nativa e pode retardar o processo de sucessão ecológica na área.
Connecting and Closed Geodesics of a Kropina Metric
Authors: Caponio Erasmo , Giannoni Fabio , Masiello Antonio , Suhr Stefan
Published: May 2021

We prove some results about existence of connecting and closed geodesics in a manifold endowed with a Kropina metric. These have applications to both null geodesics of spacetimes endowed with a null Killing vector field and Zermelo’s navigation problem with critical wind.
Transmission modes of COVID-19 disease pandemic in the light of ancient wisdom of Ayurveda medicine: a review
Authors: Joshi Namrata , Dash Manoj Kumar , Jayakumar Remya
Published: May 2021

Human-to-human transmission of the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurs most often when people are in the incubation stage of the disease or are carriers and have no symptoms. SARS-CoV-2 transmission on different levels showed that the cold and dry climate, hot wind and relative humid wind, maximum wind speed, turbulent wind, intensified recirculating flow were causing transmission higher than factors. The role of environmental factors described in Ayurveda like air, water, soil, season, frequent earthquakes, sunlight exposure, frequent thunderstorm with lightening, and factors from arthropods were revalidated in perspective of COVID-19 transmission. The authors searched the information regarding epidemic diseases in Ayurveda textbooks. Pubmed, Science Direct, Wikipedia, Elsevier, Lancet, and Springer were approached for the latest knowledge relating to SARS-CoV-2 and COVID-19. Google Scholar search engine was thoroughly checked upon for scientific evidence regarding the Ayurveda drugs. Various environmental factors like soil, air, water, frequent earthquake disasters, wildlife animals, aquatic birds, space, inevitable disastrous factors, weather or seasonal hazards, violent thunderstorm with lightning, intermediate hosts, sunlight exposure etc. were considered for their role in the genesis of the disease. The Ayurvedic concepts behind the etiology and development of epidemics are the same as modern epidemiological theories. The mysteries of many aspects of the current pandemic might be deciphered by traditional medicine knowledge and thus adding upon to the integrative medicine concept.
Wet-cupping on calf muscles in polycystic ovary syndrome: a quasi-experimental study
Authors: Meyari Azam , Tansaz Mojgan , Ramezani Tehrani Fahimeh , Mokaberinejad Roshanak , Biglarkhani Mahdi , Bidhendi Yarandi Razieh , Fayaz Mohammad
Published: May 2021

Objectives

Current modalities for treating polycystic ovary syndrome (PCOS) are not curative and using them for a long period is associated with adverse effects. According to Persian Medicine recommendations, wet cupping on calf muscles can induce menstrual bleeding. In the present study, the effect of wet-cupping (traditional bleeding from capillary vessels) was assessed on menstrual cycles (as primary outcome), hirsutism, and laboratory manifestation of PCOS.

Methods

A quasi-experimental study was conducted from 2016/5/21 until 2017/5/20 on 66 PCOS women within the age range of 20–40 years and a menstrual interval of at least 60 days during the last year. Participants’ calf muscles were cupped on day 26 of their last menstruation cycle following the Persian Medicine recommendations. They were followed for 12 weeks and a menstruation history and physical examination was done twice (4 and 12 weeks after wet cupping). Insulin Resistance (IR) and Free Androgen Index (FAI) were evaluated at baseline and end of the study.

Results

Wet-cupping on calf muscles significantly improved menstrual cycles’ frequency 0.37(95% CI: 0.13, 0.51), p-value=0.001 and hirsutism after 4 and 12 weeks of intervention were −1.9 (95% CI: −2.5, −0.5), p-value<0.001 and −1.4(95% CI: −2.1, −0.8), p-value<0.001, respectively. While it was not significant in changing the IR and FAI. About 33% of participants suffered from mild temporary discomforts (which were resolved within a few minutes of rest) and 9% reported mild long-term side effects.

Conclusions

It is considered that wet-cupping on calf muscles can be propounded as an optional treatment of PCOS for those not willing to use chemical medication.
A triple combination of treatments on moderate COVID-19
Authors: Bao ChunMiao , Li BinBin , Zhou YuFeng
Published: May 2021

Objective

A triple combination of interferon (IFN) α-2b, lopinavir tablets, and umifenovir was used to treat COVID-19 patients. It is important to explore whether the benefit of this therapy is time dependent.

Methods

A cohort of moderate COVID-19 patients (n = 54) was admitted for hospitalization. The demographic (age, gender, and smoking status) and clinical characteristics (epidemiological trace and comorbidity) were collected from the digital medical records. The length of hospital stay (LOS) and the viral shedding time (VST) were set as the outcomes for COVID-19 cases.

Results

After control for age, sex, epidemiological trace, smoking, and comorbidity, the time of treatment start had null effect on VST (IRR = 1.09; 95% CI = 0.91–1.30; p = 0.33) or LOS (IRR = 1.10; 95% CI = 0.94–1.28; p = 0.23).

Conclusion

There is no convincing evidence to support a pivotal role of the timing of the therapy in the prognosis of moderate COVID-19 cases.
Perspective of the β-blockers for the patients with diabetes and heart failure
Authors: BANDO Hiroshi
Published: May 2021

Patients with diabetes and heart failure have been increasing due to Japanese Cardiac Registry of Heart Failure in Cardiology (JCARE-CARD) study. β-blockers showed significantly suppressed cardiovascular events in the strict glycemic control group. Sodium-glucose Cotransporter-2 Inhibitors (SGLT2i) seem to be beneficial for diabetes and heart failure. Clinical efficacy of β-blockers would be suggested from three studies including Empagliflozin Cardiovascular Outcome Event Trial in Type 2 Diabetes Mellitus Patients-Removing Excess Glucose (EMPA-REG OUTCOME) trial, Canagliflozin cardioVascular Assessment Study (CANVAS) and Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure (DAPA-HF) study. Further discussion will be expected with research in detail.
Contraception & covid - 19
Authors: Belardo María Alejandra , Nardo Bárbara De , Cavanna Malena
Published: May 2021

The COVID-19 disease caused by the new coronavirus SARS-CoV-2 was first identified in December 2019 in the city of Wuhan, the People's Republic of China, and within a few months it became a pandemic. It has been a global challenge that threatens public health and has led to the implementation of strict social isolation measures. As a consequence of the health emergency, there has been a significant reduction in healthcare activity and has jeopardized access to and continuity of contraceptive methods, thus exposing women to the risk of unintended pregnancies. Sexual and reproductive rights are essential and must always be guaranteed.
Acromegaly and testicular seminoma: a rare association
Authors: L Abainou , H Eljadi , A Idrissi , A Meftah , Ismail Essadi , A Akhaddar , H Baizri
Published: May 2021

Context : Acromegaly is a chronic disease characterized by sustained elevation of circulating growth hormone and insulin-like growth factor-I (IGF-I).Epidemiological studies reported higher incidence of neoplasms in acromegalic patients especially colorectal and thyroid neoplasms. We report the case of a rare association of acromegaly to a testicular seminoma that deserves to be discussed. Case description: A 49-year-old male, who was treated for testicular seminoma, during the follow-up, acromegaly, was suspected because of typical acromegalic features, diagnosis was confirmed by elevated IGF-1 andpresence of pituitary adenoma showed by MRI. Conclusion: acromegalic patients are at an increased risk of developing neoplasms. Therefore, the clinician must have the reflex to think to look for features of acromegaly in patients with cancer as the case of our patient.
Polycystic ovary syndrome and increased risk of psychiatric disorders
Authors: Moulana PhD Mohadetheh , Sukumaran MD Anju P
Published: May 2021

Aim: This study is aimed to assess, for the first time the prevalence of polycystic ovary syndrome (PCOS) and associated psychological disorders among women at reproductive age in Mississippi. Methods: The data was collected through “the Patient Cohort Explorer” system at the University of Mississippi Medical Center (UMMC) from January 2013 to December 2018. De-identified patients were searched with diagnosis code for PCOS, age, ethnicity, and associated diagnosis including weight gain, anxiety, depression, attention-deficit/hyperactivity disorder (ADHD), and other psychological concerns. Results: Collected data from 166,748 females (19-45 years) showed 1.4% (95% CI: 1.32 – 1.44) prevalence of PCOS in women seen in UMMC clinics during the period of study. Almost 51% of patients with PCOS suffered from one or more psychological disorders; anxiety 21% (95% CI: 19.3 – 22.6), depression 20% (95% CI: 18.9 – 22.1), ADHD 3.2% (95% CI: 2.6 – 4.0), and bipolar disorder 2.5% (95% CI: 1.9 – 3.2). In addition, prevalence values suggest a positive correlation between obesity, anxiety, and depression in PCOS patients. Conclusion: Results from this study provide 1) for the first time an estimate regarding the prevalence of PCOS and associated psychological disorders in women with PCOS in a Mississippi, 2) associated psychological disorders in PCOS women may be diverse based on race and ethnicity. Our data clearly highlight that the psychological well-being of women with PCOS are affected. Therefore, it is critical for the primary care and specialty clinics to use appropriate psychological screenings. Left undiagnosed and/or untreated, chronic psychological disorders may exacerbate physical and mental health conditions.
Blood requisition and transfusion practices for elective surgical procedures at Tikur Anbessa specialized hospital, Addis Ababa, Ethiopia, 2017
Authors: Assfaw Tegu Gebrehiwot , Awol Meron Abrar , Birhan Mekuriaw Mesfin
Published: May 2021

Background: For elective surgeries preoperative over ordering of blood is very common practice and leads to holding up of the blood bank reserve, aging of the blood unit, and wastage of blood bank resources. This can be decreased by simple means of changing the blood cross-match and ordering schedule depending upon the type of surgery performed. Objectives: To assess blood requisition and transfusion practices in elective surgical procedures. Methods: Hospital-based cross-sectional study was conducted from February 1, 2017, to March 31, 2017 G.C at Tikur Anbessa specialized Hospital. Using a convenient sampling technique and structured checklist, data was collected from elective surgical patients. Blood utilization was calculated using a cross-match to transfusion ratio (C/T), transfusion probability (%T) and transfusion index (TI), and the maximum surgical blood-ordering schedule (MSBOS) is formulated by Mead's criterion for common surgical procedures. Results: Among 525 units of blood cross-matched blood, 107 units were transfused. Among all 242 elective surgical patients who had cross-matched blood, 55 (22.7%) patients were transfused with 107(20.4%) units of the prepared blood giving cross-match to transfusion ratio of 4.9, transfusion probability of 22.7% and transfusion index of 0.44. Conclusion: The amount of blood requested and cross-matched for patients undergoing elective surgery is much greater than the amount actually used. Ordering pattern needs to be revised and over-ordering of blood should be minimized.
Scope and limits of the obligations of health workers during a pandemic
Authors: Sanchez Jennifer Hincapie
Published: May 2021

The obligation to provide services, by health professionals, in a pandemic such as that caused by the SARS-Cov-2 virus is not unlimited; it is essential to take into account the risk factors of health personnel, in the event of absence and / or death, the cost benefit, the consideration of their vulnerability as being human and social being susceptible to being infected and infecting their family nucleus. That’s why it’s important to know that medicine is a humanitarian profession with deontological demands that transcend the moral plane.
The elderly, work and health present and future challenges in the aging of rural family population in the south of Brazil
Authors: Andrade Trindade Jorge Luiz de , Moraes Marielly de
Published: May 2021

This paper has the objective of discussing some aspects of work and health in people 60 years of age or more residing in rural areas in the south of Brazil, based on literature review. In our work, we have observed that the life conditions of those individuals go through different situations related to the nature of rural work, their physical situation of health and the access to quality public resources. Those are the challenges we must consider when reflecting upon the social and political issues faced by the rural elderly population.
A rare cause of cholangitis
Authors: Romano-Munive Adriana Fabiola
Published: May 2021

We described a case of hepatic artery pseudoaneurysm occurring as a complication of biliary stent migration, presented as cholangitis. It was managed by endoscopic retrograde cholangiopancreatoraphy and the pseudoaneurysm was treated with coil embolization.
Assessment of antenatal care of third trimester pregnant women attending in antenatal clinic at Mohammadpur Fertility Services & Training Centre of Dhaka, Bangladesh
Authors: B Hossain , F Akhter , Apou AC , Ahmed Rubaya , Uddin N
Published: May 2021

In Bangladesh 37% of pregnant women are taking four step of ANC treatment. The main purpose of this study was to identify the factor associated with ANC checkup. A hospital based cross sectional study at Mohammadpur Fertility Services and Training Center (MFSTC), Mohammadpur, Dhaka, Bangladesh. This cross sectional study was conveyed 100 pregnant women who visited the Mohammadpur Fertility Services and Training Center for taking antenatal checkup. Total 100 pregnant women’s data was collected in which 12%, 2nd trimester and 88% , 3rd trimester of pregnancy. According to the amount 3rd trimester of pregnant women came this hospital for antenatal checkup. Demographic data and information on age height, weight, religion, educational qualification, birth control method, health problem, blood donor, physical test, tetanus vaccine, family income level, and economical effect were collected from the patient by using a questionnaire. A good number of the pregnant women normally eaten balanced food. Some of the patients maintain the proper antenatal instruction and take more seasonal fruits and vegetable, egg, milk, fish to satisfy their nutrients for maternal health care period
Back-to-basics of hemangiosarcoma of face and scalp: a case report
Authors: Oliveira Rocha Bruno de
Published: May 2021

Introduction: Hemangiosarcoma is a rare vascular malignant neoplasm. Diagnosis is based on both clinical and histopathological features. Case Presentation: An 85-years-old white man presented with a 1-year history of progressive lesions on face and scalp. Physical examination revealed violaceous infiltrative plaques, with ulceration and bleeding, on the face and scalp, associated to numerous violaceous satellites papules. Histopathological examination revealed a neoplastic proliferation represented by slit-like anastomosing vascular channels that dissociated collagen fibers in the dermis, lined by atypical endothelium with moderately hyperchromatic and pleomorphic nuclei. Diagnostic conclusion was cutaneous angiosarcoma. Conclusions: Cutaneous angiosarcoma most often affects males (2:1), mostly Caucasian patients over 70 years old. It may originate from blood or lymphatic vessels. The most common form affects the face and scalp. There are varying degrees of cellular atypia, anastomosing slit-like channels, dissociation of collagen fibers, occasional hyaline globules and areas of hemorrhage. Immunohistochemistry confirmed blood vascular origin with diffuse positivity for CD34 and focally diffuse for factor VIII. We emphasize the need of clinicopathological correlation for early recognition and treatment.
Plasma cell mucositis with exclusive involvement of the perianal region
Authors: Bellver JL Ramirez
Published: May 2021

We present the case of a woman who has had perianal ulcers for several years. Since no improvement was achieved with topical treatments, a biopsy was performed, showing a dense lymphoplasmocellular infiltrate. After ruling out other differentials, a diagnosis of plasma cell mucositis was made and intralesional betametasone was attempted, with almost complete resolution of the lesions in a few days and no recurrence in one-year follow-up.
Effects of dexamethasone, cyclosporine and betamethasone on inflammatory cell recruitment in mice infected with Strongyloides venezuelensis
Authors: Machado Eleuza R , Ueta Marlene T , Rodrigues Rosângela Maria , Ramos Simone G , Vilhena Virgínia , Neves Eduardo Anna Maly de Leão e , Barreto dos Reis Leandro Junio , Silva Affonso Raphael da , Faccioli Lúcia Helena
Published: May 2021

The objective of this study was verified effect of immunosuppressant activities of Dexametasone (Dexa), Cyclosporine (CsA) and Betamethasone (Beta) in the synhteses of inflammatory cell and dissemination of Strongyloides venezuelensis. S. venezuelensis- infected mice increased total leucocytes (TL), eosinophil (EO), mononuclear cells (MC), and neutrophil (NE) numbers in the blood. The infection induced recruitment of TL, EO and MC to peritoneal cavity (PCF) and space bronchoalveolar (BALF), exception for NE. Dexa, CsA and Beta treatments inhibited TL, EO and MC production. However, Dexa treatment was associated with NE accumulation in the blood. Dexa and Beta tratments reductions migration of inflammatory cells from the blood to PCF and BALF. Infected mice and treated with Dexa and Beta worm parasites, eggs/g/feces and larvae recovered were higher than CsA. The results showed that glucocorticoid treatment may induce strongyloidiasis dissemination while CsA induced mice protection against S. venezuelensis infection.
National aichi biodiversity target 1-an assessment in India
Authors: Dhami Kirandeep K
Published: May 2021

The Aichi Biodiversity Targets are a set of twenty targets of the Convention on Biological Diversity (CBD) that were developed to prevent the loss of biological diversity in each participating country and measure the progress towards its conservation. Since India is a signatory to CBD, the country developed a set of twelve national targets in alignment with these twenty Aichi targets aimed to conserve biodiversity. The very first target of twelve Indian targets that were set to be achieved by 2020 was about making people aware of the values of biodiversity within ten years. This article outlines the Aichi National target one and the progress made by India towards the achievement of Aichi-12.
Strengthening Student Character Education Through Investing Multicultural Values in Madrasah
Authors: Jaya Dian Rifia , Sauri Sofyan , Muchtar Hendi Suhendraya , Warta Waska
Published: May 2021

Strengthening character education through planting multicultural values into the basic values of culture and national character. The culture and character education of this nation can be developed from the religious values and ideology of the Indonesian nation which are formulated in the goals of national education. Character is the main key to developing quality resources. That way the character must be formed as early as possible.
Archaeological Evidence of Gender Differences in Violent Repression
Authors: Díaz-Ramoneda Eulàlia , Herrasti Erlogorri Lourdes , Solé Barjau Queralt
Published: May 2021

This article discusses women who were either executed by military firing squad or killed extrajudicially during the Spanish Civil War and the Franocist dictatorship, based on evidence from the scientific exhumation of common graves in the twenty-first century. The evidence sheds light on an aspect of Francoist repression that previously has received little attention from scholars and for which few written sources are available, in contrast to executions and killings of men. Archaeological and forensic studies have documented the circumstances of how the women in the graves died, revealing differences between military executions and how extrajudicial killings were conducted. A comparison with findings from male remains found in common graves reveals gendered differences in materiality and in how victims were treated before, during and after death.
FACTORS AFFECTING THE INCIDENCE OF GROUP A Β-HEMOLYTIC STREPTOCOCCI ISOLATED FROM THROAT CULTURE
Authors: CANDAN Esra Deniz , İDİL Neslihan , TANER Abbas
Published: May 2021

Group A beta-hemolytic streptococci (GABHS) rank first among bacterial factors causing tonsillopharyngitis. These bacteria are especially common in school-age groups. The incidence increases in winter and seasonal transitions. In this study, we aim to examine the presence of GABHS in throat swab samples of people from different age groups. Therefore, we identified the reproductive frequency of GABHS in the throat culture of patients admitted with tonsillopharyngitis from 2017 to 2019 and then detected differences in the infection across age groups, months, and seasons. It was found that 8.1%, 52.4%, 21.5%, and 11.0% of isolated factors were in the age groups of 0-2, 3-6, 7-9, and 10-14, respectively. Particularly, in the 3-14 age group, the number of cases accounts for 84.9% of the total number of cases. The highest rate of infection was observed in children aged 3-6 years, and the infection was quite high in the spring (34.5%) and winter (29%). Regarding the distribution of the factor across clinics, the Department of Pediatrics was the first, and the Department of Pediatric Nephrology and Rheumatology was the second. In conclusion, controlling the spread of infections at school age is of great importance as GABHS has increased over the years.
Proteolytic enzyme and adiponectin receptors as potential targets for COVID-19 therapy
Authors: Rubina K. A. , Sabitova N. R. , Efimenko A. Yu. , Kalinina N. I. , Akopyan J. A. , Semina E. V.
Published: May 2021

The coronavirus disease 2019 (COVID-19) pandemic requires not only the creation of vaccines to prevent the spread of the disease, but also the development of novel drugs aimed at reducing viral load, suppressing an excessive immune response and preventing the severe complications such as lung fibrosis and acute respiratory distress syndrome. One of the promising targets for studying the development of pneumonia, systemic inflammation and disseminated intravascular coagulation in COVID-19 is the plasminogen activator system. In patients with a severe disease course, impaired activity or expression of plasminogen activators significantly increases the blood level of D-dimer and fibrinogen, as well as correlates with intravascular coagulation and thrombus formation. The second promising target for studying the pathogenesis of COVID-19 is the adiponectin/T-cadherin system: adiponectin is able to reduce the content of pro-inflammatory cytokines, the increase of which is characteristic of COVID-19, and stimulate the production of an anti-inflammatory cytokine interleukin-10. The review describes the role of plasminogen and T-cadherin activators in their possible participation in the development of pulmonary fibrosis in COVID-19 and hemostasis regulation, as well as cardio- and vasculoprotective function of adiponectin and its receptor, T-cadherin.
Experience of remote monitoring of patients with cardiovascular diseases in the Perm Krai
Authors: Sukhanov M. S. , Karakulova Yu. V. , Prokhorov K. V. , Spasenkov G. N. , Koryagina N. A.
Published: May 2021

The first review on the effectiveness of remote monitoring in cardiovascular patients was published in 2007, which is still relevant, reaching the peak during the Coronavirus disease 2019 (COVID-19) pandemic. Reduced availability of elective outpatient care, and sometimes reluctance of patients to visit the office due to the pandemic, required changes in ambulatory follow-up. In order to increase the availability of healthcare and reduce the mortality of Perm Krai population from cardiovascular diseases during the COVID-19 pandemic, a project for remote monitoring of high-cardiovascular-risk patients was developed and implemented.

The developed remote monitoring project represents regular phone contacts with a patient included in the remote monitoring program, according to which the need for further face-to-face consultation, additional diagnostic tests and treatment strategy is determined. The working group of the project identified indications for including patients in remote monitoring, algorithms for phone contacts and management options depending on the responses received from patients.

The project was launched in July 2020. Initially, it included five medical institutions, which selected 3901 patients.

The results will be published as the project moves forward.
Antithrombotic therapy in the elderly and senile age: the consensus opinion of experts of the Russian Association of Gerontologists and Geriatricians and the National Society of Preventive Cardiology
Authors: Tkacheva O. N. , Vorobyeva N. M. , Kotovskaya Yu. V. , Runikhina N. K. , Strazhesco I. D. , Villevalde S. V. , Drapkina O. M. , Komarov A. L. , Orlova Ya. A. , Panchenko E. P. , Pogosova N. V. , Frolova E. V. , Yavelov I. S.
Published: May 2021

В данном документе обсуждаются особенности АТТ у лиц пожилого и старческого возраста в различных клинических ситуациях.
A Prospective Study to Evaluate the Clinical Performance of A Novel MultitargetBased Antigen Test on the Detection of SARS-CoV-2 in Symptomatic PopulationComparison to Nuclear Acid-Based Tests
Authors: W Yu , E Rao , DD Wan , C Patterson , DD Wan , A Pogosyan , J Wan , J Rao
Published: May 2021

The study was designed to evaluate the clinical performance characteristics of the First Sign® SARS-CoV-2 Antigen Test, a visual read lateral flow immunoassay (W.H.P.M., Inc.). Individuals presenting at the study sites were evaluated by health care providers for COVID-19 symptoms and sequentially enrolled. The standard of care nasopharyngeal swab sample was first collected for RT-PCR testing. Participant self-collection nasal swab sample was then obtained for the Antigen Test. The clinical performance characteristics of the study device were calculated by comparing participant study device test result recorded at the point of care with the participant matched RT-PCR results provided by qualified CLIA high complexity laboratories. A total of 128 symptomatic adult participants were included in the study, of which 46.8% (60/128) were determined to be RT-PCR positive for SARS-CoV-2. The mean comparator cycle threshold value (Ct) for RT-PCR positive participants included in the study was Ct 25 (range Ct 18-Ct 39). The First Sign® SARS-CoV-2 Antigen Test demonstrated an overall clinical sensitivity of 96.7% (58/60) and a clinical specificity of 98.5% (67/68) when compared with EUA RT-PCR comparator results for the detection of SARS-CoV-2 in symptomatic individuals within 5 days of symptom onset. The clinical sensitivity for samples with RT-PCR Ct<30 was 100% (48/48), 90% (10/12) for samples with RT-PCR Ct ≥ 30, and 98.2% (55/56) for samples with RT-PCR Ct ≤ 34. Study results indicate that during the initial phase of infection, when upper respiratory viral loads and viral shedding levels are typically highest, an observed anterior nasal swab self-collected by the patient and applied to the First Sign® SARS-CoV-2 Antigen Test may be as effective in detecting the presence of SARS-CoV-2 in symptomatic individuals as a EUA RT-PCR assay. Additionally, the ability to obtain a low-cost qualitative result within 15 minutes, combined with the simplicity of the anterior nasal self-sampling procedure, may dramatically increase testing efficiency while significantly reducing risk to health care providers by minimizing or eliminating the need for close contact with the patient.
Human breast tissue dissociation and FACS vs Flowmi processing for scRNA-Seq v1
Authors: Pein Maren , not provided smallya , Nguyen Quy , Insua-Rodríguez Jacob
Published: May 2021

Single cell RNA-Seq of human breast tissue requires tissue dissociation into viable single cell suspensions. Here, we describe a protocol for digestion of human breast tissue and compare two methods to obtain viable single cell suspensions using either fluorescence activated cell sorting (FACS) or several wash steps and Flowmi cell filtering.
Mikrobiyoloji Laboratuvarında Yalın Üretim Sistemlerinin Uygulanabilirliği
Authors: ARICAN Gökhan , KÜÇÜK Burak , ARIKAN Hacer , DEVECİ Sümeyra , ARAL Murat
Published: May 2021

Giriş: Bu çalışmanın amacı hastane tıbbi mikrobiyoloji laboratuvarında mevcut durumun gözlemlenmesi, israf durumlarının tespiti, yalın üretim sistemlerinin hastane tıbbi mikrobiyoloji laboratuvarında uygulanabilirliğinin değerlendirilmesi, yalın yönetim ile ilgili eğitimlerin verilmesi, söz konusu tekniklerin kullanımı ile iyileştirilebilecek noktaların belirlenmesi ve iyileştirme önerilerinin sunulmasıdır.
Gereç Yöntem: Hastanemiz tıbbî mikrobiyoloji laboratuvarında; bakteriyoloji birimindeki iyileştirmeler için değer akış haritalandırma tekniği, laboratuvar depo alanındaki iyileştirmeler için 5S tekniği, depo-stok kontrollerinin iyileştirilmesi için balık kılçığı tekniği, örnek tüplerinin barkod problemlerini iyileştirilirken Kaizen tekniği kullanılmıştır.
Bulgular: Kan kültüründe sonuçlar incelendiğinde numunelerin kan kültürü cihazında 2094 dakikalık süre 1242 dakikaya düşürülmüştür. Hedeflenen süreye ulaşılamamış olsa dahi hedefin % 47,4’ü başarılmış, iyileştirme % 40,6 olarak gerçekleştirilmiştir. Kan kültürü testlerinde numuneler için mecburi olan 63 adımı 56 adıma düşürülmüş ve her bir numune için 7 adım (%11) tasarruf sağlanmıştır. Laboratuvar sistemi üzerindeki stok ile gerçek stoğun aynı olması sağlanmıştır. Laboratuvar deposu ve çalışma alanları düzenlenerek çalışma ortamı temiz ve düzenli hale getirilmiştir. Barkodların alınan firmaya iadesi gerçekleştirilerek, tüpe daha iyi yapışan ve bu sıkıntıları yaşatmayacak yeni barkodlarla değiştirilmiştir.
Tartışma ve Sonuç: Sağlık sektöründe yer alan kurumların yalın bakış açısı ile değerlendirilerek, kaynakları daha iyi kullanmaya ve daha verimli hizmet sunumu gerçekleştirmeye ihtiyaçları vardır. Daha uzun süreli ve daha kapsamlı bir çalışma planlanarak daha etkin sonuçlar elde edilebilecektir.
Polycystic Ovary Syndrome and Sleep Disorders: Association Between Metabolic and Androgenic Alterations with Sleep Components
Authors: TURAN Özgür Deniz
Published: May 2021

Objective: To investigate the sleep quality in patients with polycystic ovary syndrome (PCOS) and to examine the effects of metabolic parameters on sleep disturbances.

Material and Methods: The study included 50 patients diagnosed as PCOS and 51 normal healthy volunteers. The Pittsburgh Sleep Quality Index (PSQI) was used to evaluate the sleep quality. Index consists of 18 items and seven components and according to the index, the total scores of five or more indicate a poor sleep quality. After the sleep quality scores were determined, serum insulin, triglyceride, cholesterol, fasting glucose and androgen levels were recorded retrospectively and all parameters compared between groups.

Results: The sleep quality was lower in the patients with polycystic ovary syndrome than in the healthy control group but this was not statistically significant (p>0.05). Serum dehydroepiandrosterone sulfate (DHESO4) and total testosterone level had a significant negative correlation with sleep duration and total

PSQI scores. In addition, serum total testosterone level also had a significant negative correlation with sleep latency, sleep disturbance and subjective sleep quality. Besides, the patients with the poor sleep quality had significantly lower serum dehydroepiandrosterone sulfate and testosterone levels than those with a normal sleep quality (p
Forests of Japanese alder in the Russian Far East: the new association of the class Alnetea japonicae Miyawaki et al. 1977
Authors:   Botanical Garden-Institute FEB RAS, Korznikov Kirill A. , Verkholat Valentina P. , Krestov Pavel V. ,   Botanical Garden-Institute FEB RAS
Published: May 2021

We describe the new association Lycopo lucidi–Alnetum japonicae Korznikov, Verkholat & Krestov 2021 ass. nov. of the Alnus japonica swampy forests of the coastal plains and river valleys in the south of the Primorye Territory of Russia. The association includes two subassociations: Lycopo lucidi–Alnetum japonicae typicum Korznikov, Verkholat & Krestov 2021 subass. nov. and the preliminary delineated Lycopo lucidi–Alnetum japonicae betuletosum davuricae subass. prov. developing on gently sloping foothills with a lateral inflow of moisture and is transitional to zonal broad-leaved forests of the class Quercetea mongolicae Song ex Krestov et al. 2006. The association is classified to the alliance Fraxino–Alnion japonicae Miyawaki et al. 1977 described from Japan and belonging to the order Alnetalia japonicae Miyawaki et al. 1977 and the class Alnetea japonicae Miyawaki et al. 1977. We also validate the name of the association Stellario longifoliae–Alnetum japonicae Ohno in Miyawaki 1988 nom. inval. (art. 5) from Hokkaido Island, Northern Japan.
A System for Noise Control of the Technical Condition of Railroad Bridges and Tunnels in Seismically Active Regions
Authors: Aliev T. A. , Babayev T. A. , Alizada T. A. , Rzayeva N. E. , Alibayli E. E.
Published: May 2021

The authors analyze the technical condition of objects of railroad communications with modern bridges, tunnels, stations, overpasses, crossings and power installations. It is noted that, based on the specific features of such objects, control of their technical condition in most cases is carried out at certain intervals. At the same time, existing continuous control systems do not always adequately assess the technical condition of rail infrastructure objects due to the presence of additional noises in the processed signals at the time when a malfunction occurs. In this regard, one of the possible options is proposed for "continuous" monitoring of the beginning of changes in the technical condition of railroad tracks by means of noise technologies. It is pointed out that when the technical condition of rail infrastructure changes, vibration signals caused by the impact of rolling stock contain noises in addition to the useful component. The use of correlation and spectral analysis technologies, as well as other traditional methods does not allow ensuring the adequacy of the control results, due to the influence of the noise on useful vibration signals. Therefore, technologies are proposed for split analysis of the useful signal and the noise received from vibration, as well as for forming informative attributes of identification of the technical condition of rail infrastructure. In this case, the estimates of the characteristics of the useful signal and the noise are used as the main carrier of diagnostic information. Due to the simplicity and reliability of the developed theoretical algorithms, the implementation of the technical equipment and its installation in all objects of the railroad track present no particular difficulties. At the same time, the implementation of the Noise system will ensure real-time control of the beginning of changes in the technical condition of railroad tracks during the movement of the rolling stock. This, in turn, will allow timely detection of malfunctions, significantly enhancing the safety of passenger and cargo rail transportation.
HUMAN DEVELOPMENT INDEX OF UKRAINE: INDICATORS AND RATINGS
Authors: Teleshman Victor
Published: May 2021

The main purpose of the proposed paper is analysis of the current status and general trends of human development of Ukraine and selected indicators characterizing it.

The methodology of the research draws upon the system-structural analysis and the methods of comparison, analysis, generalization and synthesis. The descriptive method and the method of scientific systematization were also used.

Results. The four main components of the human development paradigm according to the 1995 Human Development Report are described, namely: productivity, equity, sustainability and empowerment. The essence of key indicators included in the system of measuring and monitoring human development is generalized, namely: average life expectancy at birth; the level of knowledge, measured by the average number of years spent on adult education and the expected years of study for first-graders; gross national income per capita in US dollars. The current state of human development in the world is analyzed, a rating of countries with the highest and lowest human development index during 1990-2018 is developed and the main causes of disparities in the level of human development between countries are identified. The countries with the largest increase and decrease in the human development index during the studied years are selected. The place of Ukraine in regional and global rankings is described. The dynamics of the human development index of Ukraine and neighboring countries during 1990-2018 is analyzed. The key issues that led to the economic, financial and political crisis and, consequently, the decline of the human development index in Ukraine since independence, including the global financial crisis of 2008 and the annexation of the Autonomous Republic of Crimea and the occupation of the territory of the eastern regions of the state (Donetsk and Luhansk regions) are highlighted.

The scientific novelty consists in the revelation of the actual features of human potential development and its individual indicators in Ukraine and in the world. The dynamics and the current state of development of the components of the human development index of Ukraine are determined. A comparative assessment of the dynamics of human development of Ukraine and neighboring countries is given.

The practical significance lies in the fact that the main provisions and conclusions of the paper can be used in further in-depth studies of the problems and prospects of human development in Ukraine.
EDUCATIONAL COMPLEX OF MYKOLAIV REGION: CURRENT STATE AND PROSPECTS OF DEVELOPMENT
Authors: Oliynyk Yaroslav , Nych Tetyana , Yavorska Karina
Published: May 2021

The purpose of research - revealing of features of development of an educational complex of the Mykolaiv area and the substantiation of the main directions of its perspective development.

The research methodology includes a system of methods: monographic, systematic approach, abstraction, mathematical, statistical, structural-functional, cartographic.

Research results. The essence of the educational complex of the region is revealed, its structure, meaning and functions are revealed. Factors of formation of an educational complex of the Mykolaiv area are revealed. Features of development and location of educational institutions are shown. Education by degree is characterized. Identified features of education levels: preschool, general, professional, fundamental professional. The estimation of the territorial organization of an educational complex of the Mykolaiv area is given. Perspective directions of further development of the educational complex of the Mykolaiv area are substantiated.

The scientific novelty of the work is the disclosure of the mechanism of formation of the educational complex of the region, the problems of its development and the directions of improvement of the territorial organization.

The practical significance of the work is that the article develops measures for further development of all components of the educational complex