bluuebunny/crossref_metadata_2025 huggingface dataset:
STRESS-TRANS-COMMUNICATIVE POTENTIAL OF THE PHYSICIAN’S PERSONALITY, WHICH IS SELF-FULFILLING IN EXTREME CONDITIONS
Authors: Marichereda V. H. , Kryvtsova N. V. , Rohachevskyi O. P. , Kazymir O. V.
Published: April 2023

The article presents the results of understanding the extremes of professional communication of physicians and argues the relevance of the problem of stress-trans-communicative potential of the individual, which is self-fulfilling in a pandemic, globalization crisis and information chaos. The possibility of applying the methodological and methodological tools of the Psychological Philosophy of Transfessionalism (author N. Kryvtsova) is considered.

It’s proven that the audio technique of de-suggestion «Is everything for the better?» (author N. Kryvtsova) is a valid tool for rapid diagnosis of psychological features of stress-trans-communicative potential of self-realization of the researcher of information resources. The effectiveness of the method is demonstrated for predicting the types-levels of deep psychological determinants of self-harmonization of cumulative and dissipative processes of self-fulfilling of an educated person in extreme conditions; for the development of skills of active listening and self-reflection, increasing the critical thinking and adequate potential of the life of an educated human, who is capable of self-actualization of the stress-trans-communicative potential of self-realization of the transferor’s personality and strengthening of mental health, in particular physicians; to increase the readiness for co-creation and conscious productive self-change in extreme conditions while preserving the authenticity of own life as a whole.

Key words: extremity, deep psychological determinants of self-fulfilling, stress-trans-communicative potential, Psychological philosophy of transfessionalism, de-suggestion.
ANALYSIS OF SEASONAL FLUCTUATIONS OF VITAMIN D LEVELS IN RESIDENTS OF SOUTHERN REGIONS OF UKRAINE DEPENDING ON GENDER AND AGE
Authors: Shanyhin A. V. , Babienko V. V. , Strakhov Ye. M.
Published: April 2023

According to the WHO, the prevalence of vitamin D deficiency has reached the level of a global pandemic. Despite the fact that deficiency and insufficiency of vitamin D are noted in various population groups all over the world, there are quite limited data on the status of 25(OH)D blood serum among residents of the Southern regions of Ukraine, who live in conditions of sufficient insolation.

The purpose of the study was to analyze the prevalence of vitamin D deficiency in residents of Southern Ukraine, depending on the season. In the course of the study, 928 residents of the Southern region of Ukraine aged from 19 to 82 were examined. The study took place during a calendar year, which made it possible to evaluate the fluctuations of the 25(OH)D level in different months with different duration of insolation. The prevalence of deficiency, insufficiency and sufficient level of vitamin D in the study group was 33.6%, 33% and 33.4%, respectively. Fluctuations in 25(OH)D levels depending on the season of the year are described.

The results obtained in the course of the study contradict a previous study conducted in Ukraine, which recorded a higher prevalence of vitamin D deficiency states, but confirms the majority of regional European studies that reflect the status of 25(OH)D in blood serum.

Key words: vitamin D deficiency, vitamin D insufficiency, prevention, risk factors, population of Ukraine.
Formation of Lexical Competence in Applicants for Education at Distance Learning (Experience of Foreign Scientists)
Authors: Lobanova Svitlana , Kovalchuk Oksana , Melnychuk Olha , Zabiiaka Iryna , Alyieva Alvina , Kanonik Nataliia
Published: April 2023

The modern peculiarities of the formation of lexical competence in students in distance education are quite acute due to the alternative organization of the scientific process and the possibility of its improvement in modern educational programs. The use of digital technologies in the learning process can be useful from the point of view of forming lexical competence and their further development in the context of strengthening the role of distance education in the modern educational program. The purpose of the article is to study the formation of lexical competence in students in distance learning, as well as the use of effective digital platforms and information technologies that can improve the components of lexical competence, such as terminology, word formation, the ability to build lexical and semantic constructions, etc. The main objective of the study is to analyze the theoretical and methodological aspects of lexical competence development in students in the context of global digitalization. The article focuses on current trends in the development of distance education and its role in the further educational process. The key prospects for development and possible ways to improve the formation of lexical competence of students studying in a distance format are outlined. Useful means of development and features of lexical competence formation are proposed, its theoretical concept is studied and its structural components are characterized. The obtained results of the study can be useful for improving the quality of the educational process in educational institutions and can be used for further development of education in the modern world.
Research Priorities for Carotid Conditions: results of the UK Vascular James Lind Alliance Priority Setting Process
Authors:   VSGBI Carotid Special Interest Group/James Lind Alliance Priority Setting Partnership, Luo X , Nortley M , Long J , Gronlund T , Bulbulia R , Halliday A , Howard DPJ
Published: April 2023

Introduction: Recent estimates of the prevalence of carotid plaque disease and carotid stenosis in people aged 39–79 years are 21.2% and 1.5% of the global population, respectively. Carotid artery disease and its management has one of the largest evidence-based areas of surgical practice, but several important questions remain unanswered. The Vascular Society of Great Britain and Ireland (VSGBI) in association with the James Lind Alliance (JLA) undertook a national Priority Setting Process (PSP) to identify carotid disease research priorities. This paper presents the results of this process. Methods: A modified JLA Priority Setting Partnership was developed to gather clinician, patient and carer research priorities for vascular conditions. Consensus workshops were held to discuss clinician and patient priorities and agree a list of joint research priorities. Consensus was achieved using a nominal group technique and a ranked ‘top 10’ list of research priorities for carotid conditions was established. Results: In the first phase (survey), 481 clinicians submitted 1,231 research priorities related to general vascular conditions. There were overlapping themes within the 1,231 priorities and, of these, 68 were carotid-specific research priorities which were reduced to six main priorities recirculated for interim scoring. In the second phase (patient and carer-led survey), 373 patients and carers submitted 582 vascular research priorities. Of these, 18 carotid priorities were reduced to 10 and recirculated for interim scoring. In the third phase (consensus workshop), clinician and patient priorities were amalgamated into 14 priorities for discussion. Finally, a ranked final ‘top 10’ list of carotid research priorities was established addressing themes including risk predication, personalised treatment, prevention, screening and surveillance. Conclusion: The ‘top 10’ carotid-related research priorities identify areas considered to be most important from the perspective of patients, carers and healthcare professionals. Researchers can now focus their efforts on addressing these important questions and funders should increase their investment to support new studies in these areas of greatest importance.
AGENT BASED APPROACH FOR TASK OFFLOADING IN EDGE COMPUTING
Authors: Morshedlou Hossein , Shoar Reza
Published: April 2023

Due to limited resource capacity in the edge network and a high volume of tasks offloaded to edge servers, edge resources may be unable to provide the required capacity for serving all tasks. As a result, some tasks should be moved to the cloud, which may cause additional delays. This may lead to dissatisfaction among users of the transferred tasks. In this paper, a new agent-based approach to decision-making is presented about which tasks should be transferred to the cloud and which ones should be served locally. This approach tries to pair tasks with resources such that a paired resource is the most preferred resource by the user or task among all available resources. We demonstrate that reaching a Nash Equilibrium point can satisfy the aforementioned condition. A game-theoretic analysis is included to demonstrate that the presented approach increases the average utility of the user and their level of satisfaction.
Editorial
Authors: Alabdulwahhab Khalid
Published: April 2023

From Editor’s Desk…

As soon as the United States and thirty-four other nations lifted their COVID-19 lockdowns, a new study from the University of California, San Francisco (UCSF) enables scientists to determine what caused an outbreak of acute severe hepatitis in otherwise healthy children in spring 2022.

Due to the rarity of pediatric hepatitis, medical professionals became concerned when they began to observe outbreaks of severe hepatitis that could not be explained. So far, there have been nearly 1,000 incidences; of these children, 50 have required liver transplants, and at least 22 have eventually died. Adeno-associated virus 2 (AAV2) being found in the blood and livers of these children could be the cause.

To determine where cases and liver transplants are higher than expected, WHO has started a global survey to estimate the incidence of severe acute hepatitis of unknown aetiology in 2022 compared to the previous five years.

After returning to school, these viruses infected children more easily. Multiple infections may have made a small number of these kids more susceptible to severe hepatitis, according to the study.

Until more is known about the etiology of these cases, the World Health Organization (WHO) recommends implementing general infection prevention and control (IPC) practices, such as:
• Frequently washing your hands with detergent and water or an alcohol-based hand gel
• Staying away from people and avoiding busy areas
• Maintaining adequate airflow while in indoors
• When necessary, wearing a mask that covers your mouth and nostrils.
• Covering sneezes and hiccups
• Drink only safe water
• Important steps to have safer food: 1. Maintain cleanliness; 2. Separate raw and cooked foods 3. Cook food thoroughly 4. Maintain food at safe temperatures 5. Use safe water and raw materials.
• Touched objects should be cleaned regularly.
• Staying home and getting medical care when sick.

Dr. Khalid Mohammed Alabdulwahhab
Editor in Chief
In Silico Structural and Functional Annotation of Helicobacter Pylori (Strain Hpag1) Hypothetical Protein Hpag1_0137
Authors: Alaidarous Mohammed
Published: April 2023

Background and Aims:
Helicobacter pylori (H. pylori) is a Gram-negative pathogenic bacterium that causes gastritis in humans. The exact molecular mechanism of most of the non-annotated hypothetical proteins involved in the virulence of H. pylori is yet to be identified. This paper aims to characterize the structure and function of the non-annotated hypothetical protein (HP) HPAG1_0137 from the H. pylori bacterium (strain HPAG1) in silico.
Methods:
We predicted several properties of HPAG1_0137, such as its physicochemical characteristics, secondary and tertiary structures, and functional annotation using different computational tools, followed by structural validation and quality assessment. We also performed virulence, protein crystallization, and active site predictions.
Results:
The study found that HPAG1_0137 has 242 amino acids and an acidic pI and is thermally stable, water-soluble, and distributed in the cytoplasm. Structurally, alpha-helices and random coils are this protein’s most prominent structural components. We found structural models to be highly native and of decent quality.
Conclusions:
This study will facilitate a better understanding of the HPAG1_0137 protein molecular mechanism of action. In addition, it will provide the basis for additional proteomic, genomic data, and structural and pharmacological research for functional and therapeutic potential identification.
Clinical manifestations and general characteristics of pediatric patients with COVID-19: A single-center study in the Makkah region, Saudi Arabia
Authors: Almutairi Sattam , Alfhmi Sumaiah , Alotaibi Amwaj , Alsaadi Farah , Alotaibi Manahel , Almofriji Wahj , Alotaibi Moawad , bagdood Sara , Rayes Bayan , Alzahrani Raid , Zamil Fatmah , Aljutaili Hayat , Alotaibi Nouf
Published: April 2023

Background and Aims:
The clinical presentations of pediatric patients infected with COVID-19 vary from mild to acute. The most commonly reported signs and symptoms are fever, cough, headache, myalgia, shortness of breath, nausea, vomiting, abdominal pain, and diarrhea. While pediatric hospitalizations are lower than those for adult patients, there is still inadequate data related to the general features of pediatric patients with COVID-19 in Saudi Arabia. This study aimed to identify clinical presentations, laboratory abnormalities, duration of hospitalizations, need for intensive care unit (ICU) admissions, and incidence of death and possible risk factors of mortality in pediatric patients.
Methods:
A retrospective study was conducted at the Maternity and Children’s Hospital in Makkah, Saudi Arabia, from March 2020 to December 2021. Pediatric patients under 18 years of age who had positive Polymerase Chain Reaction (PCR) test results for COVID-19 were included. Clinical presentations, laboratory results, medications, and any radiological abnormalities were extracted from electronic medical records and a chart review.
Results:
A total of 95 patients with a confirmed diagnosis of COVID-19 were included in the study. Of the patients, 50 (52.6%) were male, 64 (67.4%) were Saudi, and 31 (32.6%) were non-Saudi. The patients’ mean (SD) age was 3.71 (3.69) years. Their mean temperature rose to 38.34°C (0.8OC)֯, and the mean duration of their fever was 2.97 (2.8) days. The most commonly observed manifestations were diarrhea, vomiting, and abdominal pain. Of the patients, 24.2% needed ICU admission, 12.6% required mechanical ventilation, 9.5% were given vasoactive agents, 2.1% required dialysis for acute kidney injury (AKI), and 5.3% passed away. The incidence of death was significant in non-Saudi patients (P = .038).
Conclusions:
COVID-19 equally affected males and females. Most of the pediatric patients who died had co-morbidities. Fever, diarrhea, vomiting, and abdominal pain were the most prevalent symptoms.
To study the features of the use of phytotherapeutic drug Herba Gnaphalii uliginosi in combination with the main group of pharmacological drugs in the treatment of hypertension with concomitant angina
Authors:   Department of Theory and Methods of Teaching of Natural Sciences, Alexander Dovzhenko Hlukhiv National Pedagogical University, Hlukhiv, Ukraine, Lutsenko Olena
Published: April 2023

The article looks into the spread of cardiovascular diseases in the elderly in Ukraine. It is noted that with the approach of old age with the development of various somatic and mental diseases there are changes in health, changes in the direction of life interests, and changes in social status (1). It is established that the combination of a group of drugs with a non-medicinal mixture of medicinal herbs gives a positive result in lowering blood pressure, improving heart rate, and clinical performance of the cardiovascular system (2). Deep dynamic changes - a new phenomenon that is characteristic of our century, have led to a significant “aging” of the population. The aging process largely explains the high percentage of morbidity and mortality (62.5%) from cardiovascular system diseases (3). Due to the accumulation of several diseases in old age, with a predominantly chronic course and constant exacerbation, the majority of elderly people are in increased demand for medical care. At present, more than half of the patients who see a therapist at the clinic are elderly and senile (4, 5).
Ineffability as a linguistic problem
Authors: Kuzeev Sergei
Published: April 2023

The paper deals with the problem of ineffability – intuitively felt unsayability of certain mental contents that are mainly concerned with our sensual domain – and tries to transfer this notion from philosophy into the domain of cognitive linguistics. It demonstrates that in both day-to-day communication and, especially, in the language of literature, ineffability is relativized through various strategies – trivialization, deixis, verbal ellipsis, and figurativity – of which the latter is of utmost importance. The recognition of the role of figurative language in the communication of the ineffable opens up new cognitive horizons both for the notion itself and for the verbal art, which is its principal realm.
Person-marking constructions in rewritten versions of a poem by Endre Ady
Authors: Domonkosi Ágnes , Kuna Ágnes
Published: April 2023

Genres are characterized by specific patterns of person-marking constructions including pronouns, morphosyntactic elements and vocatives. The goal of this paper is to verify this hypothesis through an analysis of rewritten versions of a poem. The paper analyses various rewritten versions of Hawk Mating on the Fallen Leaves (Hu. Héja-nász az avaron) by Endre Ady and conducts software-assisted qualitative research on basic devices for person-marking in order to explore the features of person-marking constructions in the categories of “bad” poetry, 1 pop song lyrics, rap and prose (Domonkosi–Kuna 2018a). The analysis reveals that in speakers’ everyday, intuitive knowledge of genres, schemas related to various opportunities for person-marking play a fundamental role. This is suggested by the fact that the rewriting of the poem, its transposition into new genres went hand in hand with changes in the choice of person-marking constructions.
Актуальні питання організації облікової політики у закладах вищої освіти: проблематика сьогодення
Authors: Атамас О. П.
Published: April 2023

У статті проаналізовано роль облікової політики, розглянуто комплекс проблем формування та проведення облікової політики на платформах закладів вищої освіти та розкрито шляхи вирішення актуальних проблем сьогодення, які пов’язані із організацією облікової політики у закладах вищої освіти. В контексті проведеного дослідження проаналізовано термін «облікова політика» у відповідності із Законом України «Про бухгалтерський облік та фінансову звітність» та Міжнародними стандартами бухгалтерського обліку. У дослідженні розкрито та охарактеризовано систему принципів, за якими заклади вищої освіти в Україні складають щорічну облікову звітність, провадять облікову політику на своїх платформах та впроваджують кращі світові практики у своїй діяльності. Крім того, у матеріалах статті проаналізовано вплив облікової політики на фінансову стійкість закладів вищої освіти, запропоновано комплекс рекомендацій щодо вдосконалення облікової політики та впровадження закордонного досвіду в Україні.
Бухгалтерський облік розрахунків з покупцями та замовниками: історичний екскурс
Authors: Сливка Я. В. , Щербан М. Д. , Кондратюк М. Ф.
Published: April 2023

Ключовим показником розрахунків з покупцями та замовниками виступає дебіторська заборгованість, однак дане поняття ширше в частині варіативності форм розрахунків, ризиків, оподаткування, виникнення похідних фінансових інструментів, гарантійного обслуговування, комунікацій систем платежу та ін. У статті розкрито історичні передумови та розвиток розрахунків з покупцями та замовниками, їх складових. Здійснено акцент на взаємозв’язку розвитку розрахунків з покупцями та замовниками та розвитку економіки міста, країни, банківського та фінансового права, впровадження досягнень інформаційних технологій, які забезпечили додаткове залучення обігових коштів, отримання прибутку посередників, захист прав покупців та продавців. Зміна ролі конкуренції внаслідок надлишку пропозиції та обмеженості ресурсів призвела до потреби адаптації виробництво до попиту на продукцію, як наслідок, зростає роль розрахунків з покупцями та замовниками у кругообігу капіталу підприємства в цілому.
Управління якістю проєктів у готельно-ресторанному бізнесі
Authors: Січка І. І.
Published: April 2023

У статті досліджено управління якістю проєктів у готельно-ресторанному бізнесі. Зазначено, що управління якістю проєкту – це процес, який розглядає, як проєкт повинен розвиватися, щоб досягти бажаної якості результатів. Це вимагає постійного вимірювання якості діяльності та процесів. В управлінні якістю проєкту стандарти встановлюються завчасно, щоб оцінити результати, і потрібно вживати заходів протягом усього проєкту, щоб виправити помилки. У готельно-ресторанному бізнесі кінцевою метою управління якістю проєкту є гарантування результатів, які задовольняють потреби та очікування клієнтів. Виділено три компоненти управління якістю проєкту: планування якості; гарантія якості; контроль якості. Охарактеризовано, що на основі управління якістю проєкту можна отримати наступні переваги: вищий рівень задоволеності клієнтів, послуги  кращої якості, підвищена продуктивність, фінансове зростання. Здійснено аналіз інструментів, які можуть підтримувати управління якістю проєкту зважаючи на специфіку готельно-ресторанного бізнесу.
Re-Imagining Bail Decision Making: An analysis of Bail Practice in Karnataka & Recommendations for Reform
Authors:   Centre for Law and Policy Research, Krishnaswamy Sudhir , Kothari Jayna , Ganesan Deekshitha , Dutta Brototi , Tallur Ashwini , Krishnan Ashmi
Published: April 2023

The Centre for Law and Policy Research’s empirical study titled ‘Re-imagining Bail Decision Making’ looks at bail decision making in trial courts in three districts in Karnataka – Bengaluru, Dharwad and Tumakuru. It documents the outcomes on the first production of an accused before the court and evaluates the influence of different factors on a decision on whether bail is granted or not.
Full mouth rehabilitation in a worn out dentition with collapsed bite using implants-a clinical report
Authors:   Government dental college,Trivandrum, A Nazar Sumayya , V Nair Vivek , K Harshakumar , Ravichandran R
Published: April 2023

Modern dentistry changed tremendously with implant surgery.For a successful implant therapy a proper diagnosis and treatment plans is required. Teeth loss may be due to physiological as well as pathological factors are common. The complete loss of teeth causes various problems like difficulty in mastication, improper phonetics, and unacceptable esthetics of patients.Implant supported prosthesis give the dentist an opportunity to restore normal function and esthetics.Successful osseointegration enables dentist and patient to accept a full arch dental prosthesis.
Mental Health and Employment of Vietnam Preschool Teachers in Covid-19: A Research in Hanoi, Vietnam
Authors:   The Vietnam Institute of Educational Sciences, Đức Nguyễn Minh , Tâm Nguyễn Thanh ,   The Vietnam Institute of Educational Sciences
Published: April 2023

The Covid-19 pandemic has been having a very strong impact on the entire education system in Vietnam. In our education system, it can be said that preschool education is completely “frozen”. Unlike other grades where teaching is still carried out online, preschool education with its own characteristics has completely stopped all activities for quite a long time. Therefore, there have not seen any signs of reopening for preschools. This article presents some of the impacts of the Covid-19 pandemic on preschool teachers – one of the subjects who are suffering the most severely from the consequences of the pandemic, in terms of (1) mental health and (2) jobs.
An Investigation on the Implementation of Early Childhood Education: A Case Study of Selected Schools in Petauke District
Authors:   University of Zambia, Department of Education Administration and Policy Studies., Chakwaba Lizzie Chilizen , Mukalula-Kalumbi (PhD) Mwansa ,   University of Zambia, Department of Education Administration and Policy Studies.
Published: April 2023

This study investigated the implementation of early childhood education among schools in Petauke District. Despite a high enrolment rate, the children entering primary school have low levels of reading and writing skills. The study considered the benefits of ECE; the associated challenges and alternative approaches for effective implementation. Using the mixed research design, the study drew a sample of 90 respondents from 10 schools which included teachers, school administrators and parents. Data was collected by means of semi-structured questionnaires, an interview guide and focus group discussions. A combination of statistical descriptive analysis and thematic analysis was adequate for data analysis. The study found that ECE was beneficial for development of reading and writing skills; acquisition of knowledge and continuity of education to higher levels. The major challenges in ECE implementation were poor teachers’ understanding of ECE curriculum; negative attitude of parents towards ECE; poor water and sanitation; lack of ECE trained staff; poor infrastructure for ECE centres; and lack of teaching and learning materials. The alternative measures put in place included: parental sensitization and school feeding program. The overall conclusion is that the challenges and inadequacies faced by primary schools to implement ECE arise from the gaps in policy implementation and extend to institutional and domestic factors. The study contributes to the understanding that the rolling out of ECE in rural areas lags behind and that much can be done by involving the local communities and utilising available materials.
Sustainability Reporting and Economic Value Added: Empirical Evidence from Listed Manufacturing Entities in Nigeria
Authors:   Department of Accountancy, Nnamdi Azikiwe University, Awka, Nigeria, Okwudili Iliemena, Rachael , Ngozi Blessing Prof. Ijeoma, ,   Department of Accountancy, Nnamdi Azikiwe University, Awka, Nigeria, Rosemary Uagbale-Ekatah, ,   Departments of Accountancy, Benson Idahosa University, Benin, Nigeria
Published: April 2023

The essence of this study is to evaluate the effect of three aspects of Sustainability reporting on economic value addition of Nigerian listed manufacturing companies from 2013 to 2020. Ex-post facto research design was adopted while secondary data were sourced from annual reports and accounts of 37 sampled companies out of 73 listed manufacturing companies in Nigeria as at 30th September 2019. The panel data gathered for the study were subjected to empirical tests using panel regression techniques (random effect) at 5% level of significance. Evidence generated revealed among others that economic, social and environmental reporting aspects of sustainability reporting all had positive effect on economic value added over the period. However, the effects were found to be significant for economic and social reporting while the effect of environmental reporting was not statistically significant. Consequently, it was concluded that sustainability reporting has significant positive effect on economic value addition by listed manufacturing companies in Nigeria. This study therefore recommends amongst others that business organizations should incorporate sustainability reporting in their reporting system to reap the associated benefit of economic value added which should also be measured and reported annually. By policy implication, government across countries should put in place, annual awards and recognition programmes for companies with highest disclosure scores for all indices of sustainability reporting to encourage a more sustainability-driven economy, this will indirectly promote economic value added by corporations.
Sensory‑motor performance and neurochemical effects in the cerebral cortex of brain‑derived neurotrophic factor heterozygous mice fed a high‑cholesterol diet
Authors: Keser Hatice , Girit Ozlem Bozkurt , Abidin Selcen Aydin , Bilgin Mehmet Dincer , Alver Ahmet , Abidin İsmail
Published: April 2023

Reports suggest that a high‑cholesterol diet may induce neuroinflammation, oxidative stress, and neurodegeneration in brain tissue. Brain‑derived neurotrophic factor (BDNF) might play a role in protecting against changes induced by high cholesterol. We aimed to assess behavioral correlates and biochemical alterations in the motor and sensory cortices following a high‑cholesterol diet under normal and reduced BDNF concentrations. C57Bl/6 strain, wild‑type (WT) and BDNF heterozygous (+/‑) mice were used to reveal the effects of endogenous BDNF concentrations. We compared diet and genotype effects using four experimental groups: WT and BDNF heterozygous (+/‑) groups of mice were each fed a normal or high‑cholesterol diet for 16 weeks. The cylinder test and wire hanging test were performed to evaluate neuromuscular deficits and cortical sensory‑motor functions, respectively. In addition, neuroinflammation was assessed by tumor necrosis factor alpha and interleukin 6 levels measured in the somatosensory and motor areas. Additionally, MDA levels and SOD and CAT activity were evaluated as oxidative stress parameters. Results showed that a high‑cholesterol diet significantly impaired behavioral performance in the BDNF (+/‑) group. Diet did not change the levels of neuroinflammatory markers in any of the groups. However, MDA levels, an indicator of lipid peroxidation, were significantly higher in the high‑cholesterol‑fed BDNF (+/‑) mice. The results suggest that BDNF levels might be a critical factor in determining the extent of neuronal damage induced in the neocortex by a high‑cholesterol diet.
The paraventricular nucleus of the hypothalamus – the concertmaster of autonomic control. Focus on blood pressure regulation
Authors: Grzęda Emilia , Ziarniak Kamil , Sliwowska Joanna H.
Published: April 2023

The autonomic nervous system regulates internal organs and peripheral circulation, which enables the maintenance of homeostasis in vertebrate species. One of the brain regions involved in autonomic and endocrine homeostasis regulation is the periventricular  nucleus of the hypothalamus (PVN). The PVN is a unique site at which multiple input signals can be assessed and integrated. The regulation of the autonomic system by the PVN and, especially, the sympathetic flow, depends upon the integration of inhibitory and excitatory neurotransmitter action. The excitatory neurotransmitters such as glutamate and angiotensin II, and inhibitory neurotransmitters such as γ‑aminobutyric acid and nitric oxide, play a key role in the physiological function of the PVN. Moreover, arginine-vasopressin (AVP) and oxytocin (OXT) are important in the regulation of sympathetic system activity. The PVN is also crucial for maintaining cardiovascular regulation, with its integrity being pivotal for blood pressure regulation. Studies have shown that pre‑autonomic sympathetic PVN neurons increase blood pressure and the dysfunction of these neurons is directly related to elevated sympathetic nervous system activity under hypertension. Etiology of hypertension in patients is not fully known. Thus, understanding the role of PVN in the generation of hypertension may help to treat this cardiovascular disease. This review focuses on the PVN’s inhibitory and excitatory neurotransmitter interactions that regulate sympathetic system activity in physiological conditions and hypertension.
Ingeniería del Software II: Implementación, Pruebas y Mantenimiento
Authors: Celi-Párraga Ricardo Javier , Mora-Olivero Aldo Patricio , Boné-Andrade Miguel Fabricio , Sarmiento-Saavedra Juan Carlos
Published: April 2023

En este libro se investigó los procesos de implementación, pruebas y mantenimiento de la ingeniería del software y se documentó los diferentes tipos de pruebas de software para validar el correcto funcionamiento de un software, se documentó también los procesos de evolución de un software para lograr un correcto mantenimiento del software. Este libro tiene como objetivo aplicar los conceptos y teorías de validación del software con el fin de crear de software de calidad, confiable, que se encuentre disponible, protegido y seguro, para que el profesional de sistemas informáticos sea capaz de gestionar con eficiencia y en ambientes éticos y de responsabilidad proyectos inmersos en la creación software. Se investigó varios libros llegando a realizar un compendio de las partes más importantes y se llegó a la conclusión de que la ingeniería del software proporciona varias técnicas para la evaluación y validación del software y varias metodologías para el desarrollo de software confiable y seguro que el profesional puede utilizar dependiendo las diferentes necesidades, situaciones o proyectos a desarrollar
Enhancing Students' Learning Performance in Physical Education Through the Use of a Mobile Application with Game-Based Learning Approach
Authors: Culajara Carla Jobelle
Published: April 2023

Background: In response to the transition of learning from confinement at home and now having in-person classes, being flexible to the needs of students must be innovative and creative to slowly get their attention and motivation to learn.

Objectives: The objective of the study is to determine the effect of the developed mobile application to students learning performance in Physical Education.

Methods: The researcher used quasi-experimental research design utilizing pretest and posttest. Purposive sampling was used to determine the participants consisting of 25 students under control group and 25 students under experimental group which were Grade 10 students in one of the secondary schools in the Philippines. JASP Software was used to analyze the data used in the study. The research instrument was validated by the Head Teacher and Master Teacher.

Results: Data revealed that the developed mobile application has a tremendous effect on students learning performance in Physical Education. It shows that the mean scores in the before utilization on the group using the developed mobile application in the students’ learning performance has a little knowledge on the lesson, while the mean scores of the two groups after utilization shows that it has a significant effect on the learning performances. It shows that the developed mobiled application has a substantial effect on students learning performance in Physical education.

Conclusion: The developed mobile application has a significant impact to the learning of the students in Physical education. This implies that the utilization of the technology in the teaching and learning process in physical education enhances the performance and ability of an individual.
PRACA NIEREJESTROWANA JAKO NIEROZWIZANY PROBLEM RYNKU PRACY
Authors: Szewczyk-Jarocka Mariola , NOWACKA ANNA , Sawicka Janina
Published: April 2023

Celem rozwaa jest wskazanie powodw podejmowania pracy nierejestrowanej. Badania ankietowe oglnopolskie wg kwestionariusza wywiadu przeprowadzono w II poowie 2021 r. metod CATI na populacji 600 respondentw. Analizy obejmuj rozkad odpowiedzi na pytania ankietowe w caej badanej prbie oraz weryfikacj istotnoci statystycznej zalenoci pomidzy odpowiedziami a takimi zmiennymi, jak: pe, wiek, wyksztacenie, region zamieszkania. Wyniki bada wskazuj, e kobiety czciej deklaruj prac na czarno, a odsetek wskaza wykonywania pracy nierejestrowanej mala wraz z wiekiem badanych. Gwnym powodem podejmowania pracy w szarej strefie byy niewystarczajce dochody lub ich brak. Gwne powody zatrudniania przez pracodawcw bez umowy o prac lub umowy zlecenia zdaniem bezrobotnych to: brak koniecznoci opacania skadek ZUS, brak potrzeby rozliczania si z ZUS i urzdem skarbowym.
POLITYKA SPOECZNA I RYNKU PRACY OD PASTWA DOBROBYTU DO DOBROSTANU OBYWATELI KONFERENCJA NAUKOWA Z OKAZJI JUBILEUSZU 60-LECIA INSTYTUTU PRACY I SPRAW SOCJALNYCH
Authors: Gaertner Olga , Koseła Hubert
Published: April 2023

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Combining family history of coronary heart disease and individual genetic predisposition to predict the risk of major coronary events: Selected Abstract - SITeCS Congress 2022
Authors: Olmastroni Elena , Galimberti Federica , Catapano Alberico L. , Ference Brian
Published: April 2023

Background: Inherited predisposition to atherosclerosis leads to higher risk for developing coronary heart disease (CHD). There are mainly two ways to conceptualize inherited risk of CHD: family history and polygenic predisposition. We aimed at assessing the impact of family history of CHD and genetic predisposition in predicting the individual lifetime risk of major coronary events (MCE). Methods: Using adjusted Cox proportional hazard models, we estimated the lifetime risk of MCE associated with parental family history of CHD and individual genetic predisposition (estimated by a polygenic risk score including 350 variants). Results: A total of 445,744 UK-Biobank participants were included in the study (mean age 57 years; 54.3% females). Having one parent with a history of CHD increased the lifetime risk of MCE by 75% (HR 1.75, 95%CI 1.70-1.82). Having both parents with a history of CHD further increased the risk (HR 2.78, 95%CI 2.64-2.92) Similarly, a dose-dependent step-wise increase in MCE risk was observed moving from the lowest to the highest decile of the polygenic score. Compared to subjects without family history of CHD and with average level of the polygenic score, having a parental history of CHD determined an increase in lifetime risk of MCE (HR 1.90, 95%CI 1.82-1.98) comparable to belonging to the highest decile of the polygenic score (HR 1.89, 95%CI 1.76-2.02). However, if subjects present both parents with family history of CHD and a very high polygenic predisposition, the risk was even higher (HR 3.54, 95%CI 3.34-3.75), suggesting an additive contribution to the characterization of the lifetime risk. Conclusions: We described the addictive impact of family history of CHD and individual polygenic predisposition in predicting lifetime risk of MCE. In order to identify subjects at higher risk of having an early event, it is essential to retrieve information about both these hereditary components.
Nutraceutical alternatives to red yeast rice extract/monacolin K for moderate hypercholesterolaemia: Current evidence and knowledge gaps: Nutraceuticals and hypercholesterolaemia
Authors: Comi Laura , Giglione Claudia , Tolaj Fationa , Parolini Cinzia , Olivieri Chiara , Ruzza Marco , Tollemeto Valentina , Zurlo Maria , Pialorsi Federico , Seneci Antonio , Magni Paolo
Published: April 2023

The nutraceutical approach to moderate hypercholesterolaemia is an interesting option in the context of appropriate conditions associated with low cardiovascular risk, and red yeast rice (RYR) extract is one of the most utilized products in this field. Monacolin k, its main active component, reduces serum LDL-C levels via inhibition of β-Hydroxy β-methylglutaryl-CoA reductase, similarly to statins. In 2011, EFSA approved the claim regarding monacolin k from RYR extract and maintenance of normal cholesterol levels. However, in 2018, EFSA issued a warning about potential adverse effects of this nutraceutical and, in 2022, the European Commission published a Regulation with several limitations of its use. Therefore, current research and development efforts are aiming at assessing efficacy and safety of other known and novel nutraceutical products which may benefit patients with moderate hypercholesterolaemia. These active agents range from phytosterols, probiotics and berberine to bergamot, cabbage and artichoke extracts and soy protein. Moreover, plant extracts from traditional medicine, for example from African countries, are also a subject of study in this direction. The full clinical exploitation of many of them, however, still requires robust clinical evidence, which should be the objective of future research.
The XVI National Congress of the Società Italiana di Terapia Clinica e Sperimentale (SITeCS): Conference report
Authors: Casula Manuela , Aronica Alberto , Averna Maurizio , Carugo Stefano , Poli Andrea , Catapano Alberico L.
Published: April 2023

No abstract available
Guillermo Trimmiño Arango: levantamientos arquitectónicos patrimoniales en la Facultad de Arquitectura, Universidad de La Salle, Colombia. 1986 - 1993
Authors: Pasuy Arciniegas William
Published: April 2023

El presente artículo sintetiza el inventario de levantamientos arquitectónicospatrimoniales realizados en diferentes contextos de Colombia, ejercicio decarácter académico elaborado por estudiantes de la Facultad de Arquitecturade la Universidad de La Salle en el período comprendido entre los años 1986y 1993, dirigido por el arquitecto restaurador Guillermo Trimmiño Arango,en su condición de profesor de historia y taller de patrimonio. La metodologíaempleada por el profesor era eminente manual con recursos y herramientas demedición propios del momento temporal y lugar para garantizar la excelenciaen los trabajos académicos; en un primer momento se realizaba la introduccióny fundamentación sobre el tema de levantamientos de arquitectura patrimonialen el aula de clase, luego, realizaban trabajo de campo (fase de registro gráfi co,dimensional y material) directamente en el inmueble de estudio y, posteriormente,se elaboraba la planimetría que constaba de plantas, cortes, fachadas y detallesconstructivos a través de técnicas de representación gráfi ca de tinta sobre papel.El resultado revelaba tres componentes de registro en edifi caciones patrimoniales:el dibujo o expresión gráfi ca, la información dimensional o de medidas ensistema métrico y la materialidad con su respectivo sistema estructural. Sin duda,superaba el trabajo técnico por la formación profesional y reconocimiento deedifi caciones con valor patrimonial, donde no solo se incluía la historia en cadacaso de estudio sino la caracterización arquitectónica, estilos y lenguajes deinmuebles construidos entre los siglos XVII a XX en
Relationship among psychological well-being, resilience and coping with social and clinical features in Crohn's disease patients
Authors: Acciari Arlete Silva , Leal Raquel Franco , Coy Cláudio Saddy Rodrigues , Dias Cristiana Corrrêa , Ayrizono Maria de Lourdes Setsuko
Published: April 2023

Introduction: Crohn's disease is chronic, requires prolonged treatment, affects the physical and psychosocial health of patients and may alter their routine, quality of life and well-being. Recent studies recommend monitoring the health of these patients considering physical, psychological and psychosocial aspects, because they are directly related to the disease activity. These studies highlight the relevance of patients' emotional and behavioral conditions and suggest that the identification of the factors that influence the psychological well-being, resilience and Coping in these patients can favor the proper treatment. Objective: To relate psychological well-being, resilience and Coping with social and clinical features of Crohn's disease patients. Method: Prospective study including 104 patients with Crohn's disease, both genders and mean age of 39 years. Standardized scales were used to assess and to relate psychological well-being, resilience and Coping with social and clinical variables. A questionnaire to characterize the sample and standardized scales in data collection (psychological well-being, resilience pillars and Coping strategies inventory - Folkman & Lazarus) werw used. Descriptive analysis of data and statistics for comparison of results were performed. Results: There were significant differences (p< 0.05) showing better psychological well-being for male patients, those who without children, were not religious, were employed and were doing complementary activities in addition to clinical treatment. More resilience for the male gender, those who without children, were not religious, divorced, separated or widowed, that received some monthly income; who did not undergo surgery, had the first symptoms after 30 years old and who had complementary activity. There were also significant differences in the use of Coping: usually, women used more developed escape and avoidance strategies; single, married or in stable-union patients used more self-control; not religious used positive revaluation strategy; the ones who were employed showed more self-control and positive reassessment; the ones who had lower family income indicated that they used less the self-control; the ones who had higher family income used more positive re-evaluation; patients who were diagnosed with Crohn's disease between the second decade of life showed to use mores more the positive reassessment strategy than those who were 20 years old or younger. Conclusion: Social aspects influenced psychological well-being, resilience and Coping in patients with Crohn's disease more strongly than clinical aspects. It was possible to identify the profiles with better and worse psychological well-being, resilience and Coping of those who need more support, as well as to know the most used Coping strategies in the studied group.
Prognóstico de crianças e adolescentes sujeitas ao diagnóstico precoce da depressão
Authors: Martins Fernanda Lima , Granja Eliane Rabelo de Sousa , Romão Mariluce Ferreira , Amâncio Natália de Fátima Gonçalves
Published: April 2023

INTRODUÇÃO: A depressão é uma doença mental que pode ser explicada tanto por fatores genéticos, quanto orgânicos e afeta não só os adultos, mas também as crianças e adolescentes. Por conta da gravidade dessa doença e seu acometimento na vida social e profissional do indivíduo, é necessário ter diagnósticos mais precisos no seu início. METODOLOGIA: O presente estudo é uma revisão exploratória integrativa de literatura. Foram levantados 76 artigos, nos quais 56 foram excluídos e 20 incluídos. Os artigos foram identificados utilizando as bases de dados Bireme, Ebsco, Google Scholar, Pubmed e por fim Scielo. RESULTADOS: Os 20 artigos incluídos discutem sobre a gravidade da depressão e a associação com outras doenças mentais, como TDAH, borderline, bipolaridade e vícios. DISCUSSÃO: Por meio de revisões literárias e artigos produzidos entre 2012 e 2022 foi possível analisar que a depressão é uma doença psiquiátrica associada a outras doenças e muitas vezes confundida com TDAH na infância. Além disso, foi analisado o papel da família no tratamento da doença, assim como sua relação com vícios e fobias. CONCLUSÃO: Foi demonstrado que o transtorno depressivo infantil, ansiedade e fobias quando percebidas precocemente tem a probabilidade de predizer a melhora do quadro mental na idade adulta.