bluuebunny/crossref_metadata_2025 huggingface dataset:
Neural computations combine low- and high-order motion cues similarly, in dragonfly and monkey
Authors: Nitzany Eyal I. , Menda Gil , Shamble Paul S. , Golden James R. , Hu Qin , Hoy Ron R. , Victor Jonathan D.
Published: December 2017

Visual motion analysis is fundamental to survival across the animal kingdom. In insects, our understanding of the underlying computations has centered on the Hassenstein-Reichardt motion detector, which computes two-point cross-correlation via multiplication; in mammalian cortex, it is postulated that a similar signal is computed by comparing matched squaring operations. Both of these operations are difficult to implement biophysically in a precise fashion; moreover, they fail to detect the more complex multipoint local motion cues present in the visual environment. Here, via single-unit recordings in two visual specialists, dragonfly "(Odonata)" and macaque, and via model simulations, we show that neuronal computations are not simply approximations to idealized behaviors forced by biological constraints, but rather, are signatures of a common computational strategy to capture multiple local motion cues. The similarity of motion computations at the neuronal level in the brains of two extremely dissimilar animals, with evolutionary divergence of over 700 Myr1, suggests convergence on a common computational scheme for detecting visual motion.
Bivariate causal mixture model quantifies polygenic overlap between complex traits beyond genetic correlation
Authors: Frei Oleksandr , Holland Dominic , Smeland Olav B. , Shadrin Alexey A. , Fan Chun Chieh , Maeland Steffen , O’Connell Kevin S. , Wang Yunpeng , Djurovic Srdjan , Thompson Wesley K. , Andreassen Ole A. , Dale Anders M.
Published: December 2017

Accumulating evidence from genome wide association studies (GWAS) suggests an abundance of shared genetic influences among complex human traits and disorders, such as mental disorders. While current cross-trait analytical methods focus on genetic correlation between traits, we developed a novel statistical tool (MiXeR), which quantifies polygenic overlap independent of genetic correlation, using summary statistics from GWAS. MiXeR results can be presented as a Venn diagram of unique and shared polygenic components across traits. At 90% of SNP-heritability explained for each phenotype, MiXeR estimates that more than 9K variants causally influence schizophrenia, 7K influence bipolar disorder, and out of those variants 6.9K are shared between these two disorders, which have high genetic correlation. Further, MiXeR uncovers extensive polygenic overlap between schizophrenia and educational attainment. Despite a genetic correlation close to zero, these traits share more than 9K causal variants, while 3K additional variants only influence educational attainment. By considering the polygenicity, heritability and discoverability of complex phenotypes, MiXeR provides a more complete quantification of shared genetic architecture than offered by other available tools.
Deep image reconstruction from human brain activity
Authors: Shen Guohua , Horikawa Tomoyasu , Majima Kei , Kamitani Yukiyasu
Published: December 2017

Machine learning-based analysis of human functional magnetic resonance imaging (fMRI) patterns has enabled the visualization of perceptual content. However, it has been limited to the reconstruction with low-level image bases (Miyawaki et al., 2008; Wen et al., 2016) or to the matching to exemplars (Naselaris et al., 2009; Nishimoto et al., 2011). Recent work showed that visual cortical activity can be decoded (translated) into hierarchical features of a deep neural network (DNN) for the same input image, providing a way to make use of the information from hierarchical visual features (Horikawa & Kamitani, 2017). Here, we present a novel image reconstruction method, in which the pixel values of an image are optimized to make its DNN features similar to those decoded from human brain activity at multiple layers. We found that the generated images resembled the stimulus images (both natural images and artificial shapes) and the subjective visual content during imagery. While our model was solely trained with natural images, our method successfully generalized the reconstruction to artificial shapes, indicating that our model indeed ‘reconstructs’ or ‘generates’ images from brain activity, not simply matches to exemplars. A natural image prior introduced by another deep neural network effectively rendered semantically meaningful details to reconstructions by constraining reconstructed images to be similar to natural images. Furthermore, human judgment of reconstructions suggests the effectiveness of combining multiple DNN layers to enhance visual quality of generated images. The results suggest that hierarchical visual information in the brain can be effectively combined to reconstruct perceptual and subjective images.
Self-assembling all-enzyme hydrogels for biocatalytic flow processes
Authors: Peschke Theo , Gallus Sabrina , Bitterwolf Patrick , Hu Yong , Oelschlaeger Claude , Willenbacher Norbert , Rabe Kersten S. , Niemeyer Christof M.
Published: December 2017

We describe the construction of binary self-assembling all-enzyme hydrogels that are comprised entirely of two tetrameric globular enzymes, the stereoselective dehydrogenase LbADH and the cofactor-regenerating glucose 1-dehydrogenase GDH. The enzymes were genetically fused with a SpyTag or SpyCatcher domain, respectively, to generate two complementary homo-tetrameric building blocks that polymerise under physiological conditions into porous hydrogels. The biocatalytic gels were used for the highly stereoselective reduction of a prochiral diketone substrate where they showed the typical behaviour of the coupled kinetics of coenzyme regenerating reactions in the substrate channelling regime. They effectively sequestrate the NADPH cofactor even under continuous flow conditions. Owing to their sticky nature, the gels can be readily mounted in simple microfluidic reactors without the need for supportive membranes. The reactors revealed extraordinary high space-time yields with nearly quantitative conversion (>95%), excellent stereoselectivity (d.r. > 99:1), and total turnover numbers of the expensive cofactor NADP(H) that are amongst the highest values ever reported.
Isoxanthopterin: An Optically Functional Biogenic Crystal in the Eyes of Decapod Crustaceans
Authors: Palmer Benjamin A. , Hirsch Anna , Brumfeld Vlad , Aflalo Eliahu D. , Pinkas Iddo , Sagi Amir , Rozenne S. , Oron Dan , Leiserowitz Leslie , Kronik Leeor , Weiner Steve , Addadi Lia
Published: December 2017

The eyes of some aquatic animals form images through reflective optics. Shrimp, lobsters, crayfish and prawns possess reflecting superposition compound eyes, composed of thousands of square-faceted eye-units (ommatidia). Mirrors in the upper part of the eye (the distal mirror) reflect light collected from many ommatidia onto the underlying photosensitive elements of the retina, the rhabdoms. A second reflector, the tapetum, underlying the retina, back-scatters dispersed light onto the rhabdoms. Using microCT and cryo-SEM imaging accompanied byin situmicro-X-ray diffraction and micro-Raman spectroscopy, we investigated the hierarchical organization and materials properties of the reflective systems at high resolution and under close to physiological conditions. We show that the distal mirror consists of three or four layers of sparse plate-like nano-crystals. The tapetum is a diffuse reflector composed of hollow nanoparticles constructed from concentric lamellae of crystals. Isoxanthopterin, a pteridine analog of guanine, forms both the reflectors in the distal mirror and in the tapetum. The crystal structure of isoxanthopterin was determined from crystal structure prediction calculations and verified by comparison with experimental X-ray diffraction. The extended hydrogen bonded layers of the molecules results in an extremely high calculated refractive index in the H-bonded plane,n= 1.96, which makes isoxanthopterin crystals an ideal reflecting material. The crystal structure of isoxanthopterin, together with a detailed knowledge of the reflector superstructures, provide a rationalization of the reflective optics of the crustacean eye.

Significance

Aquatic animals use reflectors in their eyes either to form images or to increase photon capture. Guanine is the most widespread molecular component of these reflectors. Here we show that crystals of isoxanthopterin, a pteridine analogue of guanine, form both the image-forming ‘distal’ mirror and the intensity-enhancing tapetum reflector in the compound eyes of some decapod crustaceans. The crystal structure of isoxanthopterin was determined, providing an explanation for why these crystals are so well suited for efficient reflection. Pteridines were previously known only as pigments and our discovery raises the question of which other organic molecules may be used to form crystals with superior reflective properties either in organisms or in artificial optical devices.
An ordered pattern of Ana2 phosphorylation by Plk4 is required for centriole assembly
Authors: McLamarrah Tiffany A. , Buster Daniel W. , Galletta Brian J. , Boese Cody J. , Ryniawec John M. , Hollingsworth Natalie A. , Byrnes Amy E. , Brownlee Christopher W. , Slep Kevin C. , Rusan Nasser M. , Rogers Gregory C.
Published: December 2017

Polo-like kinase 4 (Plk4) initiates an early step in centriole assembly by phosphorylating Ana2/STIL, a structural component of the procentriole. Here, we show that Plk4 binding to the central coiled-coil (CC) of Ana2 is a conserved event, involving Polo-box 3 and a previously unidentified putative CC located adjacent to the kinase domain. Ana2 binding stimulates Plk4 kinase activity in vitro, and, in turn, is phosphorylated along its length. Previous studies showed that Plk4 phosphorylates the C-terminal STAN domain of Ana2/STIL, triggering binding and recruitment of the cartwheel protein Sas6 to the procentriole assembly site. However, the physiological relevance of N-terminal phosphorylation was unknown. We found that Plk4 first phosphorylates the extreme N–terminus of Ana2 which is critical for subsequent STAN domain modification. Phosphorylation of the central region then breaks the Plk4-Ana2 interaction. This phosphorylation pattern is important for centriole assembly and integrity because replacement of endogenous Ana2 with phospho-Ana2 mutants disrupts distinct steps in Ana2 function and inhibits centriole duplication.
Boosting ATM Activity Promotes Longevity in Nematodes and Mice
Authors: Qian Minxian , Liu Zuojun , Peng Linyuan , Meng Fanbiao , Tang Xiaolong , Ao Ying , Shi Lei , Zhou Mingyan , Wang Ming , Qin Baoming , Cao Xinyue , Wang Zimei , Zhou Zhongjun , Liu Baohua
Published: December 2017

DNA damage accumulates with age1. However, whether and how robust DNA repair machinery promotes longevity is elusive. Here, we demonstrate that activation of ataxia-telangiectasia mutated (ATM) via low dose of chloroquine (CQ) promotes DNA damage clearance, rescues age-related metabolic shift, and extends lifespan in nematodes and mice. Molecularly, ATM phosphorylates SIRT6 deacetylase and thus prevents MDM2-mediated ubiquitination and proteasomal degradation. Extra copies ofSirt6inAtm-/- mice extend lifespan, accompanied with restored metabolic homeostasis. In a progeria mouse model with low ATM protein level and DNA repair capacity, the treatment with CQ ameliorates premature aging features and extends lifespan. Thus, our data highlights a pro-longevity role of ATM, for the first time establishing direct causal links between robust DNA repair machinery and longevity, and providing therapeutic strategy for progeria and age-related metabolic diseases.
Multiple Determinants and Consequences of Cohesion Fatigue in Mammalian Cells
Authors: Sapkota Hem , Wasiak Emilia , Gorbsky Gary J.
Published: December 2017

Cells delayed in metaphase with intact mitotic spindles undergo cohesion fatigue, where sister chromatids separate asynchronously, while cells remain in M phase. Cohesion fatigue requires release of sister chromatid cohesion. However, the pathways necessary to breach sister chromatid cohesion during cohesion fatigue remain unknown. Using a regulated protein heterodimerization system to lock different cohesin interfaces at specific times in mitosis, we show that the prophase pathway of Cohesin release is not required for cohesion fatigue. By manipulating microtubule stability and Cohesin complex integrity in cell lines with varying sensitivity to cohesion fatigue, we show that rates of cohesion fatigue reflect a dynamic balance between spindle pulling forces and resistance to separation by interchromatid cohesion. Cohesion fatigue that results in complete chromatid separation may be an unrecognized but common source of chromosome instability. Here, we extend the significance of cohesion fatigue by showing that even limited delays at metaphase lead to partial centromere separation and predispose cells to chromosome missegregation.
Patterns in protein flexibility: a comparison of NMR “ensembles”, MD trajectories and crystallographic B-factors
Authors: Riga Anthony , Rivera Jasmin , Snyder David A.
Published: December 2017

Proteins are molecular machines requiring flexibility to function. Crystallographic B-factors and Molecular Dynamics (MD) simulations both provide insights into protein flexibility on an atomic scale. Nuclear Magnetic Resonance (NMR) lacks a universally accepted analog of the B-factor, however, a lack of convergence in atomic coordinates in an NMR-based structure calculation also suggests atomic mobility. This paper describes a pattern in the coordinate uncertainties of backbone heavy atoms in NMR-derived structural “ensembles” first noted in the development of FindCore2 (previously called Expanded FindCore: DA Snyder, J Grullon, YJ Huang, R Tejero, GT Montelione,Proteins: Structure, Function, and Bioinformatics82 (S2), 219–230) and demonstrates that this pattern exists in coordinate variances across MD trajectories but not in crystallographic B-factors. This either suggests that MD trajectories and NMR “ensembles” capture motional behavior of peptide bond units not captured by B-factors or indicates a deficiency common to force fields used in both NMR and MD calculations. Additionally, a comparison of Cα B-factors with Cα coordinate variability in NMR “ensembles” and MD trajectories shows that NMR-derived coordinate uncertainties measure variability in atomic positions as well as crystallographic B-factors and superimpositions of MD trajectories do.
Nup98 regulation of histone methylation promotes normal gene expression and may drive leukemogenesis
Authors: Sump Bethany , Brickner Jason H.
Published: December 2017

Nuclear pore proteins (Nups) interact with chromosomes to regulate gene expression and chromatin structure. A new study by Franks and colleagues (pp. 2222–2234) provides new mechanistic insight into the molecular basis by which Nup98 promotes gene activation in normal hematopoietic cells and how that process is altered by translocations to cause excess expression of developmental genes in leukemia.
Retrofitting heritage office buildings in the UK: a case study
Authors: Tokede Olubukola , Udawatta Nilupa , Luther Mark
Published: December 2017

Purpose

Heritage buildings are a crucial part of the UK built sector. They perpetuate a sense of identity, prestige and community. Many heritage buildings however tend to be energy inefficient and the scope for retrofitting such buildings is paramount. Heritage buildings require ratification from planning bodies in order to undertake any alteration on the building. This tends to create a bottleneck in the retrofitting of heritage office buildings. The paper aims to discuss this issue.

Design/methodology/approach

This study utilises a case study building in Scotland to evaluate the potential for retrofitting in a UK heritage office building. Building energy simulation software is used to generate the energy data in different retrofit options. A scenario analysis on the heritage status of the building is also undertaken.

Findings

The costs, energy consumption and carbon emission levels are evaluated and compared. It was found that the differential in annual energy savings achieved, based on the proportion of capital cost to operational cost, is 14.6 per cent in the heritage building, compared to 24.6 per cent in the non-heritage building.

Originality/value

The study suggests that government and other stakeholders should seek for ways of incentivising retrofit investments in heritage buildings. This will provide an effective way of minimising the contributions of the built environment to global warming and climate change.
Operations capability, productivity and business performance
Authors: Yu Wantao , Ramanathan Ramakrishnan , Wang Xingyu , Yang Jiehui
Published: December 2017

Purpose

The purpose of this paper is to investigate the relationships between operations capability, productivity, and business performance in the context of environmental dynamism.

Design/methodology/approach

A proposed conceptual framework grounded in the resource-based view (RBV) and dynamic capability view (DCV) is analyzed using archival data from 193 automakers in the UK.

Findings

The results show that operations capability, as an important dynamic capability, has a significant positive effect on productivity, which in turn leads to improved business performance. The results also suggest that productivity fully mediates the relationship between operations capability and business performance, and that environmental dynamism significantly moderates the relationship between operations capability and productivity.

Practical implications

The research findings provide practical insights that will help managers develop operations capability to gain greater productivity and business performance in a dynamic environment.

Originality/value

Addressing the two important issues of moderation (i.e. environmental dynamism) and mediation (i.e. productivity), this study makes important contributions to the field of operations management by applying the RBV and DCV.
Supply chain quality and pricing decisions under multi-manufacturer competition
Authors: Pang Jiangang , Tan Kim Hua
Published: December 2017

Purpose

In today’s global competition, supply chain quality management is the key to a firms’ competitiveness. However, managers find that making sound quality and pricing decisions under a complex multi-echelon in the current competitive electronic commerce environment is daunting and challenging. The purpose of this paper is to examine the optimum quality strategies under different cooperative mechanisms and investigate its effects on channel members’ profits.

Design/methodology/approach

This paper is a result of a China-UK collaborative research effort, involving researchers with expertise in information systems, quality management, supply chain management, pricing, and game theory models. The authors consider the quality decisions of a single product in a supply chain system that consists of a supplier and two competing manufacturers. The authors examine the optimum quality strategies under different cooperative mechanisms and investigate its effects on channel members’ profits. A modified Nerlove-Arrow model is employed to investigate the quality levels on goodwill and product sales.

Findings

The results reveal that the traditional cooperative program is not very effective in the horizontal competitive market; and each channel member may have a profit improvement when the supplier integrates with a manufacturer.

Originality/value

The authors believe that this paper will contribute to the existing body of knowledge. Moreover, the paper provides insights for managers to better manage their supply chain quality management in an information-centric context.
A comparison between structural equation modelling (SEM) and Bayesian SEM approaches on in-store behaviour
Authors: Ong Fon Sim , Khong Kok Wei , Yeoh Ken Kyid , Syuhaily Osman , Nor Othman Mohd.
Published: December 2017

Purpose

The purpose of this paper is to examine the effects of atmospherics and affective state on shoppers’ in-store behaviour using the two approaches in structural equation modelling (SEM), i.e. Frequentist and Bayesian approaches. Shoppers’ affective state was tested for its mediating effect on in-store shopping behaviour.

Design/methodology/approach

The final sample consists of 382 respondents who were drawn from shoppers at selected apparel stores in six of the most popular shopping malls around Kuala Lumpur (Malaysia). A frequentist approach to SEM is common among researchers and offers generally an analysis of the relationships between multiple latent variables and constructs. Alternatively, the Bayesian SEM (BSEM) approach stems from the diffusion of the model’s posterior distributions using the Markov Chain Monte Carlo technique. More specifically, this technique is inherently more flexible and substantive in determining parameter estimates as compared to the more conventional, the frequentist approach to SEM.

Findings

The results show the mixed effects of atmospheric cues in retail setting on shoppers’ affective state. More specifically, the positive direct effect of atmospheric cues (music) on in-store behaviour was confirmed while other atmospheric cues (colour and store layout) were found to be fully mediated by affective state. The Bayesian approach was able to offer more distinctive results complementing the frequentist approach.

Research limitations/implications

Although the current sample size is adequate, it will be interesting to examine how a bigger sample size and different antecedents of in-store behaviour in retailing can affect the comparison between the frequentist approach in SEM and BSEM.

Practical implications

The authors found that a combination of well-designed store atmospherics and layout store can produce pleasurable effects on shoppers resulting in positive affective state. This study found that results from both frequentist and Bayesian approaches complement each other and it may be beneficial for future studies to utilise both approaches in SEM.

Originality/value

This paper met the aim to compare the approaches in SEM and the need to consider both approaches on in-store shopping environment. Overall, the authors contend that the Bayesian approach to SEM is a potentially viable alternative to frequentist SEM, especially when studies are conducted under dynamic conditions such as apparel retailing.
Projecting futuristic scenarios for Indian Railway Security System (IRSS) using fuzzy dominance and contingency planning
Authors: Srivastava Anoop , Gaur Sant Kumar , Swami Sanjeev , Banwet Devinder Kumar
Published: December 2017

Purpose

Physical security has remained an important reason for, and the consequence of, societal living. In recent times, the threat potential and the risks of loss and damage due to criminal activities have increased substantially. In Indian Railways, it is being increasingly felt that efficient security management is inevitable for the development and sustainability of desired state of affairs. The purpose of this paper is to address the broad goal of achieving optimal strategies for minimizing security threats to Indian Railway Security System (IRSS).

Design/methodology/approach

The authors use two forecasting techniques, namely, Delphi technique and Harva method, whose joint approach allows the authors to use both quantifiable (Delphi technique) and linguistic (Harva method) data. The choice of the two approaches provides a multi-method approach to the research problem.

Findings

Predicted trend toward the expected scenario in 2020 has more or less matched with the actual developments for improvement in security scenario of Indian Railways. The positive indications are that there is an improving trend, which is expected to lead to a much better state of affairs with certain inputs.

Research limitations/implications

The joint approach of Delphi technique and Harva method is a multi-method example of original research work in the railway security, which can also be implemented in other security settings, such as aviation or marine security. A replication of the exercise closer to the target date will throw light on the exact state of affairs in the area of railway security in India.

Practical implications

An outcome in consonance with the present exercise has been the implementation of the policy developed on the basis of the forecasts. Policy efforts initiated in the recent past have been consistent with the features discussed in the study. From the above indicators, it can be inferred that some of the policy initiatives taken are in line with the trend status as predicted by the Delphi exercise.

Social implications

Security has been considered as an important reason, as well as a consequence, of living in a society. It has been perceived as the condition of being protected against danger or loss, and also refers to the freedom from exposure to danger (protection), implying a feeling of assurance against danger. Research work in this area, thus, has strong social welfare implications. This is particularly so as the area of security gained importance, not only in India, but also across the world.

Originality/value

The present study is the first of its kind in the area of railway security using systems approach. The approach used is quite generic and can also be implemented in other security settings, such as aviation or marine security.
Lean-Kaizen implementation
Authors: Kumar Sunil , Dhingra Ashwani , Singh Bhim
Published: December 2017

Purpose

The purpose of this paper is to present a road map to implement Lean-Kaizen concept using value stream mapping (VSM) to identify hidden continuous improvement opportunities in a small and medium-sized enterprise (SME) located at the non-capital region of India.

Design/methodology/approach

From the collected data, a current state map was prepared that indicated the current operating situation of selected SME. The takt time was calculated and those processes which attained higher cycle time (C/T) than takt time were identified. The continuous flow processing was achieved by adjusting C/T of each process and supermarket pull system was developed to control the production at the workstations. Finally, a future state map was developed that served as a guide for future lean activities. Few problems were identified to realize the future state. The “5-why” analysis was used for identifying root causes of these problems and Kaizen events were proposed as solutions. In this case study, one Kaizen event was identified in which brainstorming technique was used to control the variation caused by unorthodox fixture design for clamping and de-clamping of case product and thus eliminated non-value-added activities performed by the operator on a milling machine.

Findings

Before and after implementation of value stream map, the data obtained were analyzed and eliminated rework time, reduced inventory level, reduced lead time and C/T, improved productivity and product quality are presented as finding. Lean-Kaizen provides a better chance for every individual of the industry to have a hand in achieving organization’s goals to attain continuous progress in productivity and quality of the product. Even good understanding of the concept of lean tools and techniques by SMEs, the employee willingness and motivation to identify and eliminate wastes are found feeble.

Originality/value

This study is among best practices to identify hidden improvement opportunities in the regular production of the product to increase productivity and improve quality using value stream map. The research paper gives useful understandings to the lean implementers, Kaizen identifiers, consultants and researchers.
SWOT analysis of Jamaican academic libraries in higher education
Authors: Harris Sasekea Yoneka
Published: December 2017

Purpose

Academic libraries do not operate in a vacuum; they must co-exist with change and competition on all levels. In order to succeed, they must know their internal strengths in order to take advantage of opportunities, whilst avoiding threats and addressing weaknesses. A SWOT analysis of Jamaican academic libraries can yield strategic insights for academic library praxis in Jamaica, the Caribbean, and the globe. The paper aims to discuss these issues.

Design/methodology/approach

Survey and discussion group were engaged for the five local academic libraries in higher education in Jamaica.

Findings

Human resources and support are the most recurrent themes in the reported strengths, weaknesses, opportunities and threats.

Research limitations/implications

This paper focused on local academic libraries in higher education (university level) in Jamaica. A survey of academic libraries at all levels, and using more detailed strategic analytical tools, would be a useful follow up.

Practical implications

This paper provides academic library managers and the national/regional library associations with a situational analysis of Jamaican academic librarianship, which can be used to inform future planning and management of library and information services. Additionally, the findings can inform the Latin America and Caribbean section of international library documents on trends, issues and future position of academic libraries globally.

Originality/value

This paper is of value as it is the first published scholarly documentation on the strengths, weaknesses, opportunities and threats in academic librarianship in Jamaica. In this regard, it makes a useful contribution to the dearth of literature on SWOT analyses of academic libraries per country. It may also represent a starting point for looking at solutions and emerging challenges in a Caribbean academic library environment and should help to focus on the need for continuing innovation.
Blended learning
Authors: Keisling Bruce
Published: December 2017

Purpose

Because many colleges and universities have growing numbers of students in online and blended programs, libraries should adapt their services and adjust their organizational structures to support them. Students have adopted blended learning programs whether or not the programs are officially designed as blended programs. Libraries need to change their service orientation in response and learn to scale services using available technologies. Scaling services and personnel resources also requires developing a scalable organizational learning culture. The paper aims to discuss these issues.

Design/methodology/approach

Using a change in support for online/distance students and organizational restructuring in Ekstrom Library at the University of Louisville as a case study, this paper examines the review process, organizational restructuring, and focus on scaling services that resulted in a new service model.

Findings

This study found that scaling services as applied to IT and business organizations is also valuable as an approach in enhancing library services to online students. Changing user needs must be correlated with available organizational resources and technological solutions to deliver appropriate services. Modifying and building services with a goal of scaling them to appropriate levels will enhance library outcomes.

Research limitations/implications

Other case studies concerned with responding to changing student expectations and scaling services and organizational resources would be useful to add to these findings.

Originality/value

The perspectives and approach described in this case study will be instructive for adapting library services to changing user environments.
Using data to strategically deploy staffing resources
Authors: Williams Michael
Published: December 2017

Purpose

The environmentally controlled library warehouse stores ten million collection items and its team of staff provides a delivery service to the students and researchers. Statistics show that the demand for the service was much higher than the forecast at the design stage and, as a result, the operationally intensive environment had bottlenecks and backlogs, which were affecting the service-level agreements. It was clear that the staffing levels were inadequate to meet the demand, so there was a need to capture data to enable evidence-based decision making to restructure and supplement staffing. The paper aims to discuss these issues.

Design/methodology/approach

Each of the activities undertaken by staff were observed and timed over extended periods, which resulted in detailed measurements for each elemental task. On the basis of known demand for services, the author was able to extrapolate these measurements to model the demand on services and, therefore, the staffing requirement for a whole year.

Findings

The author was able to provide evidence to show that the levels of staffing were inadequate and two further full-time equivalent staff were required. The data also highlighted specific areas that required higher and lower levels of resourcing than those were currently provided.

Originality/value

The research was motivated by operational need in an environment where meeting service-level agreements is a key performance indicator. The methods can be applied to many library activities and are especially applicable to repetitive or high-intensity tasks. It is equally valuable in library operations where there is a perception that staffing levels are inadequate but it is not clear how additional staffing should be deployed.
Performance auditing in Germany concerning environmental issues
Authors: Weihrich Dietmar
Published: December 2017

Purpose

This paper aims to provide knowledge concerning performance auditing by examining the implementation in Germany. The text shows how the principles of performance auditing are implemented in Germany. The German approach is special because the international standards are not implemented in Germany, and there are neither any existing scientific studies nor any other literature concerning performance audit in Germany.

Design/methodology/approach

The study comprises a general discussion of the goals and boundaries of performance auditing with an environmental perspective based on a literature study. The text also describes the theoretical, legal and methodological background of performance audits in Germany. Findings concerning the status quo of performance auditing in Germany are based on an analysis of audits conducted by public audit institutions. The findings were compared with findings from other current international studies.

Findings

The sample of scrutinized audits conducted by the public audit institutions shows clearly that the provisions of the German Federal Budget Code had been fully implemented. In nearly every study, implications of economy, efficiency and effectiveness have been considered. Hence, even without any references to the international standards, the core principles of performance audit are considered in the audits conducted by the public audit institutions in Germany. The main focus in the audits had been placed on the efficiency and effectiveness. It is also very remarkable how far-reaching the findings of the audits in Germany are. Especially, in terms of scrutinized subsidy directives, the public audit institutions are not reducing their recommendations to the implementation of the granting-process but to the directives itself.

Research limitations/implications

The paper highlights a sample of studies which is limited in terms of quantity because it focused on audits related to environmental protection.

Practical implications

The study provides knowledge on how audits are conducted by public audit institutions in Germany. In doing so, it is particularly helpful for people dealing with public audits, especially in the government and the audit institutions.

Social implications

The paper examines the role of public audit institutions that contribute to a more efficient and an effective deployment of public expenditures. The goal is to avoid wasting public means by using it without causing positive effects. This is the basis for a socially just usage of public means.

Originality/value

The paper contributes to a better understanding of performance auditing in general. As there are no documented scientific studies or other papers concerning the implementation of performance audit in Germany, the paper is of high-innovatory value. The findings are very important to the further development of performance audit. In addition, by depicting the role of public audit institutions in Germany, it allows comparisons to the situation in other countries.
Removal of Cr(VI) from aqueous solutions by using activated carbon supported iron catalysts as efficient adsorbents
Authors: Derdour Karima , Bouchelta Chafia , Khorief Naser-Eddine Amina , Medjram Mohamed Salah , Magri Pierre
Published: December 2017

Purpose

The purpose of this paper is to focus on the removal of hexavalent chromium [Cr(VI)] from wastewater by using activated carbon-supported Fe catalysts derived from walnut shell prepared using a wetness impregnation process. The different conditions of preparation such as impregnation rate and calcination conditions (temperature and time) were optimized to determine their effects on the catalyst’s characteristics.

Design/methodology/approach

The catalyst samples were characterized using thermogravimetric analysis, scanning electron microscopy and Fourier transform infrared spectroscopy. The adsorption of Cr(VI) by using using activated carbon supported Fe catalysts derived from walnut shell as an adsorbent and catalyst was investigated under different adsorption conditions. The parameters studied were contact time, adsorbent dose, solution pH and initial concentrations.

Findings

Results showed that higher adsorption capacity and rapid kinetics were obtained when the activated walnut shell was impregnated with Fe at 5 per cent and calcined under N2 flow at 400°C for 2 h. The adsorption isotherms data were analyzed with Langmuir and Freundlich models. The better fit is obtained with the Langmuir model with a maximum adsorption capacity of 29.67 mg/g for Cr(VI) on Fe5-AWS at pH 2.0.

Originality/value

A comparison of two kinetic models shows that the adsorption isotherms system is better described by the pseudo-first-order kinetic model.
Experimental small‐scale flower patches increase species density but not abundance of small urban bees
Authors: Simao Maria‐Carolina M. , Matthijs Jill , Perfecto Ivette
Published: December 2017

Large flower plantings are often used to combat negative effects of habitat loss on pollinators, but whether these floral additions are effective at smaller scales remains unclear, particularly in urban settings.

To test the effectiveness of small‐scale floral additions on enhancing urban bee populations, as well as their impact from 1 year to the next, different quantities of potted sweet alyssum (Lobularia maritima) flowers were placed across sites in Ann Arbor, Michigan for two consecutive years and the resulting Halictid bee visitors were monitored.

Overall, we found the number of flowers added at the local level was significantly and positively correlated with small Halictid bee abundance and species density in an urban landscape. At smaller flower quantities, dynamics were clearly linear, where incremental increases in number of flowers showed significant increases in bee abundance and species density. At larger quantities of floral additions, however, dynamics were nonlinear in that incremental increases in flower quantity had no effect on bee abundance and highly variable effects on bee species density.

When comparing the change in small Halictid bee abundance and species density from 1 year to the next, we found a significant increase in bee species density in the second year of small‐scale floral additions, but no significant difference in bee abundance.

Synthesis and applications. Our results show that small flower plantings can have positive effects on small bee communities in urban systems even over a short period of time and therefore confirm that encouraging citizens to plant flowers can be an effective conservation strategy for certain urban pollinator populations. In addition, our finding that smaller flower plantings may have higher impacts on small pollinators than larger plantings suggests resource managers interested in pollinator conservation should consider spreading multiple, smaller floral plantings across the urban landscape, rather than pooling all resources into one large flower patch.
Blocking transferrin receptor inhibits the growth of lung adenocarcinoma cells in vitro
Authors: Wu Yihe , Xu Jinming , Chen Jinbo , Zou Meirong , Rusidanmu Aizemaiti , Yang Rong
Published: December 2017

Background

Transferrin receptor (TfR) is expressed in most lung cancers and is an indicator of poor prognosis in certain groups of patients. In this study, we blocked cell surface TfR to inhibit lung adenocarcinoma (LAC) cell growth in vitro and investigated the associated molecular mechanisms to determine a potential therapeutic target in human LAC.

Methods

RNA interference and antibody blocking techniques were used to block the function of TfR in LAC cells, and cell proliferation assays were used to detect the results. Affymetrix microarray analysis was conducted using H1299 cells in which TfR was blocked with an antibody to investigate the molecular mechanisms involved.

Results

The cell proliferation assay demonstrated that H1299 cell proliferation was significantly inhibited after small interfering RNA knockdown or blocking of TfR. Mechanistic studies found that 100 genes were altered more than two‐fold after TfR was blocked and that blocking TfR was accompanied by decreased expression of the oncogene KRAS.

Conclusion

Our data provide evidence that blocking TfR could significantly inhibit LAC proliferation by targeting the oncogene KRAS; therefore, TfR may be a therapeutic target for LAC. In addition, our results suggest a new method for blocking the signal from the oncogene KRAS by targeting TfR in LAC.
Investigating the Relationships Between Alcohol Consumption, Cannabis Use, and Circulating Cytokines: A Preliminary Analysis
Authors: Karoly Hollis C. , Bidwell L. Cinnamon , Mueller Raeghan L. , Hutchison Kent E.
Published: December 2017

Background

In recent years, human and animal studies have converged to support altered inflammatory signaling as a molecular mechanism underlying the pathophysiology of alcohol use disorders (AUDs). Alcohol binds to receptors on immune cells, triggering signaling pathways that produce pro‐inflammatory cytokines. Chronic inflammation is associated with tissue damage, which may contribute to negative effects of AUD. Conversely, cannabis is associated with decreased inflammatory signaling, and animal studies suggest that cannabinoids may impact alcohol‐induced inflammation. Thus, the impact of cannabis on inflammation in AUDs in humans warrants examination.

Methods

We explored the relationship between self‐reported alcohol and cannabis use and circulating levels of the pro‐inflammatory cytokines interleukin 6 (IL‐6), IL‐8, and IL‐1β in the blood. Among 66 regular drinkers (mean age = 30.08), we examined circulating cytokines and administered questionnaires assessing alcohol consumption and days of cannabis use over the past 90 days. We examined whether alcohol consumption, cannabis use, and gender were associated with changes in circulating cytokines, and whether there was a significant interaction between alcohol and cannabis use predicting blood levels of circulating cytokines.

Results

A positive association between alcohol and IL‐6 emerged. We also observed a negative association between cannabis and IL‐1β. Follow‐up moderation analyses indicated a cannabis by alcohol interaction predicting circulating IL‐6, such that cannabis nonusers showed a stronger relationship between alcohol and IL‐6 compared to cannabis users.

Conclusions

These preliminary findings suggest that cannabinoid compounds may serve to mitigate inflammation associated with alcohol use. In addition, the present results provide data to inform future investigations, with the goal of ultimately leveraging knowledge of the role of inflammation in AUDs to develop more effective treatments focused on novel immune targets.
Neurodevelopmental origins of abnormal cortical morphology in dissociative identity disorder
Authors: Reinders A. A. T. S. , Chalavi S. , Schlumpf Y. R. , Vissia E. M. , Nijenhuis E. R. S. , Jäncke L. , Veltman D. J. , Ecker C.
Published: December 2017

Objective

To examine the two constitutes of cortical volume (CV), that is, cortical thickness (CT) and surface area (SA), in individuals with dissociative identity disorder (DID) with the view of gaining important novel insights into the underlying neurobiological mechanisms mediating DID.

Methods

This study included 32 female patients with DID and 43 matched healthy controls. Between‐group differences in CV, thickness, and SA, the degree of spatial overlap between differences in CT and SA, and their relative contribution to differences in regional CV were assessed using a novel spatially unbiased vertex‐wise approach. Whole‐brain correlation analyses were performed between measures of cortical anatomy and dissociative symptoms and traumatization.

Results

Individuals with DID differed from controls in CV, CT, and SA, with significantly decreased CT in the insula, anterior cingulate, and parietal regions and reduced cortical SA in temporal and orbitofrontal cortices. Abnormalities in CT and SA shared only about 3% of all significantly different cerebral surface locations and involved distinct contributions to the abnormality of CV in DID. Significant negative associations between abnormal brain morphology (SA and CV) and dissociative symptoms and early childhood traumatization (0 and 3 years of age) were found.

Conclusions

In DID, neuroanatomical areas with decreased CT and SA are in different locations in the brain. As CT and SA have distinct genetic and developmental origins, our findings may indicate that different neurobiological mechanisms and environmental factors impact on cortical morphology in DID, such as early childhood traumatization.
Regression Analysis for Secondary Response Variable in A Case-Cohort Study
Authors: Pan Yinghao , Cai Jianwen , Kim Sangmi , Zhou Haibo
Published: December 2017

Case-cohort study design has been widely used for its cost-effectiveness. In any real study, there are always other important outcomes of interest beside the failure time that the original case-cohort study is based on. How to utilize the available case-cohort data to study the relationship of a secondary outcome with the primary exposure obtained through the case-cohort study is not well studied. In this article, we propose a non-parametric estimated likelihood approach for analyzing a secondary outcome in a case-cohort study. The estimation is based on maximizing a semiparametric likelihood function that is built jointly on both time-to-failure outcome and the secondary outcome. The proposed estimator is shown to be consistent, efficient, and asymptotically normal. Finite sample performance is evaluated via simulation studies. Data from the Sister Study is analyzed to illustrate our method.