bluuebunny/crossref_metadata_2025 huggingface dataset:
Platelet-Activating Factor Acetylhydrolase Expression in BRCA1 Mutant Ovarian Cancer as a Protective Factor and Potential Negative Regulator of the Wnt Signaling Pathway
Authors: Liao Yue , Badmann Susann , Kaltofen Till , Mayr Doris , Schmoeckel Elisa , Deuster Eileen , Mannewitz Mareike , Landgrebe Sarah , Kolben Thomas , Hester Anna , Beyer Susanne , Burges Alexander , Mahner Sven , Jeschke Udo , Trillsch Fabian , Czogalla Bastian
Published: June 2021

Aberrantly activated Wnt/β-catenin signaling pathway, as well as platelet-activating factor (PAF), contribute to cancer progression and metastasis of many cancer entities. Nonetheless, the role of the degradation enzyme named platelet-activating factor acetylhydrolase (PLA2G7/PAF-AH) in ovarian cancer etiology is still unclear. This study investigated the functional impact of platelet-activating factor acetylhydrolase on BRCA1 mutant ovarian cancer biology and its crosstalk with the Wnt signaling pathway. PAF-AH, pGSK3β, and β-catenin expressions were analyzed in 156 ovarian cancer specimens by immunohistochemistry. PAF-AH expression was investigated in ovarian cancer tissue, serum of BRCA1-mutated patients, and in vitro in four ovarian cancer cell lines. Functional assays were performed after PLA2G7 silencing. The association of PAF-AH and β-catenin was examined by immunocytochemistry. In an established ovarian carcinoma collective, we identified PAF-AH as an independent positive prognostic factor for overall survival (median 59.9 vs. 27.4 months; p = 0.016). PAF-AH correlated strongly with the Wnt signaling proteins pGSK3β (Y216; nuclear: cc = 0.494, p < 0.001; cytoplasmic: cc = 0.488, p < 0.001) and β-catenin (nuclear: cc = 0.267, p = 0.001; cytoplasmic: cc = 0.291, p < 0.001). In particular, high levels of PAF-AH were found in tumor tissue and in the serum of BRCA1 mutation carriers. By in vitro expression analysis, a relevant gene and protein expression of PLA2G7/PAF-AH was detected exclusively in the BRCA1-negative ovarian cancer cell line UWB1.289 (p < 0.05). Functional assays showed enhanced viability, proliferation, and motility of UWB1.289 cells when PLA2G7/PAF-AH was downregulated, which underlines its protective character. Interestingly, by siRNA knockdown of PLA2G7/PAF-AH, the immunocytochemistry staining pattern of β-catenin changed from a predominantly membranous expression to a nuclear one, suggesting a negative regulatory role of PAF-AH on the Wnt/β-catenin pathway. Our data provide evidence that PAF-AH is a positive prognostic factor with functional impact, which seems particularly relevant in BRCA1 mutant ovarian cancer. For the first time, we show that its protective character may be mediated by a negative regulation of the Wnt/β-catenin pathway. Further studies need to specify this effect. Potential use of PAF-AH as a biomarker for predicting the disease risk of BRCA1 mutation carriers and for the prognosis of patients with BRCA1-negative ovarian cancer should be explored.
Porcine Decellularized Diaphragm Hydrogel: A New Option for Skeletal Muscle Malformations
Authors: Boso Daniele , Carraro Eugenia , Maghin Edoardo , Todros Silvia , Dedja Arben , Giomo Monica , Elvassore Nicola , De Coppi Paolo , Pavan Piero Giovanni , Piccoli Martina
Published: June 2021

Hydrogels are biomaterials that, thanks to their unique hydrophilic and biomimetic characteristics, are used to support cell growth and attachment and promote tissue regeneration. The use of decellularized extracellular matrix (dECM) from different tissues or organs significantly demonstrated to be far superior to other types of hydrogel since it recapitulates the native tissue’s ECM composition and bioactivity. Different muscle injuries and malformations require the application of patches or fillers to replenish the defect and boost tissue regeneration. Herein, we develop, produce, and characterize a porcine diaphragmatic dECM-derived hydrogel for diaphragmatic applications. We obtain a tissue-specific biomaterial able to mimic the complex structure of skeletal muscle ECM; we characterize hydrogel properties in terms of biomechanical properties, biocompatibility, and adaptability for in vivo applications. Lastly, we demonstrate that dECM-derived hydrogel obtained from porcine diaphragms can represent a useful biological product for diaphragmatic muscle defect repair when used as relevant acellular stand-alone patch.
Successful Hemispherotomy in a Patient with Encephalopathy with Continuous Spikes and Waves during Sleep Related to Neonatal Thalamic Hemorrhage: A Case Report with Intracranial Electroencephalogram Findings
Authors: Baba Shimpei , Okanishi Tohru , Nozaki Toshiki , Ichikawa Naoki , Sakakura Kazuki , Nishimura Mitsuyo , Yonekawa Takahiro , Enoki Hideo , Fujimoto Ayataka
Published: June 2021

Neonatal thalamic hemorrhage is a strong risk factor for developing encephalopathy with continuous spikes and waves during sleep (ECSWS), even when not accompanied by widespread cortical destruction. The efficacy and indication of resective epilepsy surgery in such patients has not yet been reported. A 4-year-old boy was diagnosed with ECSWS based on strong epileptiform activation during sleep and neurocognitive deterioration. He had a history of left thalamic hemorrhage related to a straight sinus thrombosis during the newborn period. He presented with daily absence seizures that were refractory to medical treatment. At age 5, he underwent intracranial electroencephalogram (EEG) recording using depth and subdural strip electrodes placed in the left thalamus and over bilateral cortex, respectively. Interictal and ictal epileptiform discharges were observed in the thalamus, always preceded by discharges in the left or right parietal lobe. Left hemispherotomy successfully normalized the EEG of his unaffected hemisphere and extinguished his seizures. This is the first case report documenting resective epilepsy surgery in a patient with ECSWS due to neonatal thalamic injury without widespread cerebral destruction. Based on intracranial EEG findings, his injured thalamus did not directly generate the EEG abnormalities or absence seizures on its own. Patients with ipsilateral neonatal thalamic injury and even mild lateralized cortical changes may be candidates for resective or disconnective surgery for ECSWS.
Fluorescent Nanodiamonds Synthesized in One-Step by Pulsed Laser Ablation of Graphite in Liquid-Nitrogen
Authors: Cazzanelli Massimo , Basso Luca , Cestari Claudio , Bazzanella Nicola , Moser Enrico , Orlandi Michele , Piccoli Alessandro , Miotello Antonio
Published: June 2021

In this work, we present a relevant upgrade to the technique of pulsed laser ablation of fluorescent nanodiamonds (NDs), relying on an automatized graphite-target movement maintaining a constant level of liquid nitrogen over its surface during hours of deposition. Around 60 mg of NDs nanopowder was synthesized and optomagnetically characterized to assess its optical quality. Chemical purification of the ablated nanopowders, which removes the graphitic byproducts, permits to obtain pure fluorescent NDs with an efficiency of 7 ± 1% with respect to the total nanopowder mass. This value compares positively with the efficiency of other commercial NDs synthesis techniques such as detonation, cavitation, and high pressure–high temperature.
Detection of Hepatocellular Carcinoma in a High-Risk Population by a Mass Spectrometry-Based Test
Authors: Mahalingam Devalingam , Chelis Leonidas , Nizamuddin Imran , Lee Sunyoung S. , Kakolyris Stylianos , Halff Glenn , Washburn Ken , Attwood Kristopher , Fahad Ibnshamsah , Grigorieva Julia , Asmellash Senait , Meyer Krista , Oliveira Carlos , Roder Heinrich , Roder Joanna , Iyer Renuka
Published: June 2021

Hepatocellular carcinoma (HCC) is one of the fastest growing causes of cancer-related death. Guidelines recommend obtaining a screening ultrasound with or without alpha-fetoprotein (AFP) every 6 months in at-risk adults. AFP as a screening biomarker is plagued by low sensitivity/specificity, prompting interest in discovering alternatives. Mass spectrometry-based techniques are promising in their ability to identify potential biomarkers. This study aimed to use machine learning utilizing spectral data and AFP to create a model for early detection. Serum samples were collected from three separate cohorts, and data were compiled to make Development, Internal Validation, and Independent Validation sets. AFP levels were measured, and Deep MALDI® analysis was used to generate mass spectra. Spectral data were input into the VeriStrat® classification algorithm. Machine learning techniques then classified each sample as “Cancer” or “No Cancer”. Sensitivity and specificity of the test were >80% to detect HCC. High specificity of the test was independent of cause and severity of underlying disease. When compared to AFP, there was improved cancer detection for all tumor sizes, especially small lesions. Overall, a machine learning algorithm incorporating mass spectral data and AFP values from serum samples offers a novel approach to diagnose HCC. Given the small sample size of the Independent Validation set, a further independent, prospective study is warranted.
PTEN Hamartoma Tumor Syndrome/Cowden Syndrome: Genomics, Oncogenesis, and Imaging Review for Associated Lesions and Malignancy
Authors: Dragoo David D. , Taher Ahmed , Wong Vincenzo K. , Elsaiey Ahmed , Consul Nikita , Mahmoud Hagar S. , Mujtaba Bilal , Stanietzky Nir , Elsayes Khaled M.
Published: June 2021

PTEN hamartoma tumor syndrome/Cowden syndrome (CS) is a rare autosomal dominant syndrome containing a germline PTEN mutation that leads to the development of multisystem hamartomas and oncogenesis. Benign tumors such as Lhermitte–Duclos disease and malignant tumors involving the breast, thyroid, kidneys, and uterus are seen in CS. Radiologists have an integral role in the comanagement of CS patients. We present the associated imaging findings and imaging screening recommendations. Knowledge of the types of cancers commonly seen in CS and their imaging findings can aid in early tumor recognition during cancer screening to help ensure near-normal life spans in CS patients.
Light-Driven Hydrogen Evolution Assisted by Covalent Organic Frameworks
Authors: Romero Nuria , Bofill Roger , Francàs Laia , García-Antón Jordi , Sala Xavier
Published: June 2021

Covalent organic frameworks (COFs) are crystalline porous organic polymers built from covalent organic blocks that can be photochemically active when incorporating organic semiconducting units, such as triazine rings or diacetylene bridges. The bandgap, charge separation capacity, porosity, wettability, and chemical stability of COFs can be tuned by properly choosing their constitutive building blocks, by extension of conjugation, by adjustment of the size and crystallinity of the pores, and by synthetic post-functionalization. This review focuses on the recent uses of COFs as photoactive platforms for the hydrogen evolution reaction (HER), in which usually metal nanoparticles (NPs) or metallic compounds (generally Pt-based) act as co-catalysts. The most promising COF-based photocatalytic HER systems will be discussed, and special emphasis will be placed on rationalizing their structure and light-harvesting properties in relation to their catalytic activity and stability under turnover conditions. Finally, the aspects that need to be improved in the coming years will be discussed, such as the degree of dispersibility in water, the global photocatalytic efficiency, and the robustness and stability of the hybrid systems, putting emphasis on both the COF and the metal co-catalyst.
Ferrocenylimine Palladium (II) Complexes: Synthesis, Characterization and Application in Mizoroki-Heck and Suzuki-Miyaura Cross-Coupling Reactions
Authors: Matsheku Asanda C. , Tia Richard , Maumela Munaka C. , Makhubela Banothile C. E.
Published: June 2021

Carbon-carbon cross-coupling reactions are essential synthetic tools for synthesizing polymers, natural products, agrochemicals, and pharmaceuticals. Therefore, new catalysts that function with greater efficiency and functional group tolerance are being researched. We have prepared new ferrocenylimine monodentate N and P donor ligands and N^N and N^P bidentate chelating ligands (L1 to L4) employed in stabilizing palladium ions for application in Mizoroki-Heck and Suzuki-Miyaura cross-coupling reactions. The ferrocenylimine ligands were successfully synthesized by Schiff base condensation reactions of acetyl ferrocene with hydrazine monohydrate to afford ferrocenyl hydrazone (L1). Ligand L1 was further treated with aldehydes to give ferrocenyl(2-diphenylphosphino)imine (L3) and ferrocenyl(pyridyl)imine (L3), while phosphination of L1 with chlorodiphenylphosphine afforded L2. The ligands were used to prepare new palladium(II) complexes (C1 to C4) by complexation with [PdCl2(MeCN)2]. All the ligands and complexes were fully characterized using standard spectroscopic and analytical techniques, including 1H NMR and 13C NMR spectroscopy, FT-IR spectroscopy, mass spectrometry and elemental analysis. The complexes (C1 to C4) were tested for efficacies in catalyzing Mizoroki-Heck and Suzuki-Miyaura C-C cross-coupling reactions and proved to be suitable catalyst precursors. Ferrocenyl(2-diphenylphosphine)imino and ferrocenyl-methyl hydrazone palladium(II) complexes C2 and C3 showed the best activities at TONs of up to 201. The ferrocenyl palladium(II) (pre)catalysts demonstrated moderate activity in Mizoroki-Heck reactions involving substrates with substituents on the olefin and aryl halide (including 4-Cl, 4-CH3, -CO2Me and -CO2Et). Density Functional Theory was used to study the mechanism of the Mizoroki-Heck cross-coupling reactions and have led to confirmation of the widely accepted catalytic cycle. Catalyst precursors (C1 to C4) also displayed good activity and selectivity in Suzuki-Miyaura cross-coupling reactions, at 0.5 mol% catalyst loading, with good tolerance to functional groups present on the aryl halide and boronic acid substrates (such as 4-Cl, 4-CHO, 4-COOH, 3-NO2, 3,5-dimethoxy and 4-CH3).
Development and Characterization of Two Types of Surface Displayed Levansucrases for Levan Biosynthesis
Authors: Shang Huiyi , Yang Danni , Qiao Dairong , Xu Hui , Cao Yi
Published: June 2021

Levan has wide applications in chemical, cosmetic, pharmaceutical and food industries. The free levansucrase is usually used in the biosynthesis of levan, but the poor reusability and low stability of free levansucrase have limited its large-scale use. To address this problem, the surface-displayed levansucrase in Saccharomyces cerevisiae were generated and evaluated in this study. The levansucrase from Zymomonas mobilis was displayed on the cell surface of Saccharomyces cerevisiae EBY100 using a various yeast surface display platform. The N-terminal fusion partner is based on a-agglutinin, and the C-terminal one is Flo1p. The yield of levan produced by these two whole-cell biocatalysts reaches 26 g/L and 34 g/L in 24 h, respectively. Meanwhile, the stability of the surface-displayed levansucrases is significantly enhanced. After six reuses, these two biocatalysts retained over 50% and 60% of their initial activities, respectively. Furthermore, the molecular weight and polydispersity test of the products suggested that the whole-cell biocatalyst of levansucrase displayed by Flo1p has more potentials in the production of levan with low molecular weight which is critical in certain applications. In conclusion, our method not only enable the possibility to reuse the enzyme, but also improves the stability of the enzyme.
Resilience Against COVID-19: How Italy Faced the Pandemic in Pediatric Orthopedics and Traumatology
Authors: Trisolino Giovanni , Toniolo Renato Maria , Marengo Lorenza , Dibello Daniela , Guida Pasquale , Panuccio Elena , Evangelista Andrea , Stallone Stefano , Sansò Maria Lucia , Amati Carlo , Costici Pier Francesco , Boero Silvio , Farsetti Pasquale , De Sanctis Nando , Verdoni Fabio , Memeo Antonio , Gigante Cosimo
Published: June 2021

Background: We aimed to investigate the variation of medical and surgical activities in pediatric orthopedics in Italy, during the year of the COVID-19 pandemic, in comparison with data from the previous two years. The differences among the first wave, phase 2 and second wave were also analyzed. Methods: We conducted a retrospective multicenter study regarding the clinical and surgical activities in pediatric orthopedics during the pandemic and pre-pandemic period. The hospital databases of seven tertiary referral centers for pediatric orthopedics and traumatology were queried for events regarding pediatric orthopedic patients from 1 March 2018 to 28 February 2021. Surgical procedures were classified according to the “SITOP Priority Panel”. An additional classification in “high-priority” and “low-priority” surgery was also applied. Results: Overall, in 2020, we observed a significant drop in surgical volumes compared to the previous two years. The decrease was different across the different classes of priority, with “high-priority” surgery being less influenced. The decrease in emergency department visits was almost three-fold greater than the decrease in trauma surgery. During the second wave, a lower decline in surgical interventions and a noticeable resumption of “low-priority” surgery and outpatient visits were observed. Conclusion: Our study represents the first nationwide survey quantifying the impact of the COVID-19 pandemic on pediatric orthopedics and traumatology during the first and second wave.
Epilepsy in Mitochondrial Diseases—Current State of Knowledge on Aetiology and Treatment
Authors: Wesół-Kucharska Dorota , Rokicki Dariusz , Jezela-Stanek Aleksandra
Published: June 2021

Mitochondrial diseases are a heterogeneous group of diseases resulting from energy deficit and reduced adenosine triphosphate (ATP) production due to impaired oxidative phosphorylation. The manifestation of mitochondrial disease is usually multi-organ. Epilepsy is one of the most common manifestations of diseases resulting from mitochondrial dysfunction, especially in children. The onset of epilepsy is associated with poor prognosis, while its treatment is very challenging, which further adversely affects the course of these disorders. Fortunately, our knowledge of mitochondrial diseases is still growing, which gives hope for patients to improve their condition in the future. The paper presents the pathophysiology, clinical picture and treatment options for epilepsy in patients with mitochondrial disease.
Enhancing Density-Based Mining Waste Alkali-Activated Foamed Materials Incorporating Expanded Cork
Authors: Beghoura Imed , Castro-Gomes Joao
Published: June 2021

This study focuses on the development of an alkali-activated lightweight foamed material (AA-LFM) with enhanced density. Several mixes of tungsten waste mud (TWM), grounded waste glass (WG), and metakaolin (MK) were produced. Al powder as a foaming agent was added, varying from 0.009 w.% to 0.05 w.% of precursor weight. Expanded granulated cork (EGC) particles were incorporated (10% to 40% of the total volume of precursors). The physical and mechanical properties of the foamed materials obtained, the effects of the amount of the foaming agent and the percentage of cork particles added varying from 10 vol.% to 40% are presented and discussed. Highly porous structures were obtained, Pore size and cork particles distribution are critical parameters in determining the density and strength of the foams. The compressive strength results with different densities of AA-LFM obtained by modifying the foaming agent and cork particles are also presented and discussed. Mechanical properties of the cured structure are adequate for lightweight prefabricated building elements and components.
The Effect of Whey Protein-Based Edible Coatings Incorporated with Lemon and Lemongrass Essential Oils on the Quality Attributes of Fresh-Cut Pears during Storage
Authors: Galus Sabina , Mikus Magdalena , Ciurzyńska Agnieszka , Domian Ewa , Kowalska Jolanta , Marzec Agata , Kowalska Hanna
Published: June 2021

This study aimed to determine the effect of edible coatings based on whey protein isolate and essential oils (lemon and lemongrass) on the colour, hardness, polyphenols and flavonoids content, structure, and sensory attributes of fresh-cut pears during storage at 4 °C. The optical and barrier properties of the edible films were also determined. Analysed films showed good transparency (Lightness 86.6–95.0) and excellent oxygen and carbon dioxide permeability, which were reduced due to the presence of lemon and lemongrass essential oils. Pears were coated by immersion in a solution containing 8% of whey protein isolate and the addition of lemon oil at 1.0% or lemongrass essential oil at 0.5%. Coating caused a reduction in colour changes, loss in hardness, polyphenols and flavonoids. The study showed that the highest efficiency was demonstrated by the whey protein isolate coatings without the addition of essential oils by preserving the colour and firmness of fresh-cut pears. For these samples, the highest sensory acceptability was also achieved.
A Comprehensive Review on Surface Modifications of Biodegradable Magnesium-Based Implant Alloy: Polymer Coatings Opportunities and Challenges
Authors: Saberi Abbas , Bakhsheshi-Rad Hamid Reza , Abazari Somayeh , Ismail Ahmad Fauzi , Sharif Safian , Ramakrishna Seeram , Daroonparvar Mohammadreza , Berto Filippo
Published: June 2021

The development of biodegradable implants is certainly intriguing, and magnesium and its alloys are considered significant among the various biodegradable materials. Nevertheless, the fast degradation, the generation of a significant amount of hydrogen gas, and the escalation in the pH value of the body solution are significant barriers to their use as an implant material. The appropriate approach is able to solve this issue, resulting in a decrease the rate of Mg degradation, which can be accomplished by alloying, surface adjustment, and mechanical treatment. Surface modification is a practical option because it not only improves corrosion resistance but also prepares a treated surface to improve bone regeneration and cell attachment. Metal coatings, ceramic coatings, and permanent polymers were shown to minimize degradation rates, but inflammation and foreign body responses were also suggested. In contrast to permanent materials, the bioabsorbable polymers normally show the desired biocompatibility. In order to improve the performance of drugs, they are generally encapsulated in biodegradable polymers. This study summarized the most recent advancements in manufacturing polymeric coatings on Mg alloys. The related corrosion resistance enhancement strategies and future potentials are discussed. Ultimately, the major challenges and difficulties are presented with aim of the development of polymer-coated Mg-based implant materials.
Vessel Wall Inflammatory Activity as Determined by F-18 Fluorodeoxyglucose PET in Large Vessel Vasculitis Is Attenuated by Immunomodulatory Drugs
Authors: Sherzay Romilda , Witte Torsten , Derlin Thorsten , Hoepfner Marius , Bengel Frank M.
Published: June 2021

F-18 fluorodeoxyglucose (F-18 FDG) PET/CT plays an increasing role in the diagnostic workup of large vessel vasculitis (LVV); however, information on the relationship between immunosuppressive drugs and vessel wall uptake is limited. In 94 patients with a confirmed diagnosis of LVV, the vessel wall-to-liver ratio (VLR) was assessed in eight vessel segments. Patients were grouped according to intake of immunomodulatory drugs (Group 1, prednisone; Group 2, prednisone + methotrexate; and Group 3, prednisone + others) and compared to treatment-naïve individuals. A total of 54/94 (57.4%) were treated with immunomodulatory drugs (Group 1, 29/49 (53.7%); Group 2, 9/54 (16.7%); Group 3, 11/54 (20.4%); and Group 4, 5/54 (9.3%)), whereas the remainder received no therapy (40/94 (42.6%)). The mean VLR of the arterial segments correlated significantly with the hematopoietic organs (r ≥ 0.22, p ≤ 0.05), c-reactive protein (r ≥ 0.25, p ≤ 0.05), and prednisone dosage (r ≥ −0.4, p ≤ 0.05). Relative to treatment-naïve patients, a significantly lower VLR was recorded in 5/8 (62.5%) of the investigated vessel segments in Group 1 (p ≤ 0.02), in 6/8 of the vessel segments in Group 2 (75.0%, p ≤ 0.006), and in 7/8 of the segments in Group 3 (87.5%, p ≤ 0.05). In LVV, the F-18 FDG uptake in vessel wall as a marker of inflammatory activity was attenuated by immunomodulatory drugs, which provides a foundation for future serial monitoring of treatment efficacy.
Trial Design for a Diagnostic Accuracy Study of a Point-of-Care Test for the Detection of Taenia solium Taeniosis and (Neuro)Cysticercosis in Community Settings of Highly Endemic, Resource-Poor Areas in Zambia: Challenges and Rationale
Authors: Van Damme Inge , Trevisan Chiara , Mwape Kabemba , Schmidt Veronika , Magnussen Pascal , Zulu Gideon , Mubanga Chishimba , Stelzle Dominik , Bottieau Emmanuel , Abatih Emmanuel , Phiri Isaac , Johansen Maria , Chabala Chishala , Winkler Andrea , Dorny Pierre , Gabriël Sarah ,   on behalf of the SOLID Consortium
Published: June 2021

Field-applicable, high-quality, and low-cost diagnostic tools are urgently needed for Taenia solium. The aim of this paper is to describe the design, challenges, and rationale for the design of a diagnostic accuracy study in low-resource community settings in Zambia. The trial was designed as a prospective study with a two-stage design to evaluate a new point-of-care test (TS POC) for the detection of taeniosis and (neuro)cysticercosis. Participants within randomly selected households were tested with the TS POC test (index test). Participants who tested TS POC positive for taeniosis and/or cysticercosis and a subset of the negatives were requested to give blood and stool samples for reference testing, and to undergo clinical examination and a cerebral CT scan. The difficulties of conducting a clinical trial in settings with limited research and neuroimaging infrastructure as well as peculiarities specifically related to the disease (low prevalence of taeniosis and the lack of a gold standard) were taken into consideration for the design of this study. The two-stage design increased the efficiency of the study by reducing the number of samples, clinical examinations, and CT scans. Simplified flows and sampling processes were preferred over complex follow-up and randomization systems, aiming to reduce bias and increase the generalizability of the study.
Neoliberalism and the Environment: Are We Aware of Appropriate Action to Save the Planet and Do We Think We Are Doing Enough?
Authors: Jones Ellie-Anne , Stafford Rick
Published: June 2021

We currently face several interlinked environmental crises, including climate change, habitat destruction and biodiversity loss. However, many governments seem unwilling to take strong and immediate action to address these threats, preferring to promote neoliberal approaches to allow consumers and the general public to make environmentally friendly choices. This is despite neoliberal approaches being much less likely to be successful than government leadership, taxation, subsidies, and legislation in addressing environmental issues. In this study, we examine public perception of environmental threats and solutions to these threats in a survey mainly completed in the UK. Climate change is seen as the biggest issue, likely due to recent activist campaigns and subsequent media attention on the issue. Neoliberal attitudes, such as green consumer choices to environmental concerns, do still dominate in a series of possible presented solutions, and they score more highly than lifestyle changes, such as changing diet. However, when questioned specifically about plastic pollution, government intervention to ban all unnecessary plastic scored very strongly, indicating a shift from a consumer-driven response. Furthermore, most participants think they are at best only partly “doing their bit” to protect the environment. The results demonstrate that the public is aware that not enough is happening to protect the environment and provide evidence that there is willingness for stronger government intervention to address environmental issues; however, there is potential resistance to major lifestyle changes.
Biomass Burning and Water Balance Dynamics in the Lake Chad Basin in Africa
Authors: Black Forrest W. , Lee Jejung , Ichoku Charles M. , Ellison Luke , Gatebe Charles K. , Babamaaji Rakiya , Abdollahi Khodayar , San Soma
Published: June 2021

The present study investigated the effect of biomass burning on the water cycle using a case study of the Chari–Logone Catchment of the Lake Chad Basin (LCB). The Chari–Logone catchment was selected because it supplies over 90% of the water input to the lake, which is the largest basin in central Africa. Two water balance simulations, one considering burning and one without, were compared from the years 2003 to 2011. For a more comprehensive assessment of the effects of burning, albedo change, which has been shown to have a significant impact on a number of environmental factors, was used as a model input for calculating potential evapotranspiration (ET). Analysis of the burning scenario showed that burning grassland, which comprises almost 75% of the total Chari–Logone land cover, causes increased ET and runoff during the dry season (November–March). Recent studies have demonstrated that there is an increasing trend in the LCB of converting shrubland, grassland, and wetlands to cropland. This change from grassland to cropland has the potential to decrease the amount of water available to water bodies during the winter. All vegetative classes in a burning scenario showed a decrease in ET during the wet season. Although a decrease in annual precipitation in global circulation processes such as the El Niño Southern Oscillation would cause droughts and induce wildfires in the Sahel, the present study shows that a decrease in ET by the human-induced burning would cause a severe decrease in precipitation as well.
Application of Taylor Rule Fundamentals in Forecasting Exchange Rates
Authors: Agyapong Joseph
Published: June 2021

This paper examines the effectiveness of the Taylor rule in contemporary times by investigating the exchange rate forecastability of selected four Organisation for Economic Co-operation and Development (OECD) member countries vis-à-vis the U.S. It employs various Taylor rule models with a non-drift random walk using monthly data from 1995 to 2019. The efficacy of the model is demonstrated by analyzing the pre- and post-financial crisis periods for forecasting exchange rates. The out-of-sample forecast results reveal that the best performing model is the symmetric model with no interest rate smoothing, heterogeneous coefficients and a constant. In particular, the results show that for the pre-financial crisis period, the Taylor rule was effective. However, the post-financial crisis period shows that the Taylor rule is ineffective in forecasting exchange rates. In addition, the sensitivity analysis suggests that a small window size outperforms a larger window size.
Special Issue on Application of Electronic Devices on Intelligent System
Authors: Meen Teen-Hang , Kuo Cheng-Chien
Published: June 2021

In a modern technological society, electronic engineering and design innovations are both academic and practical engineering fields that involve systematic technological materialization through scientific principles and engineering designs [...]
Cognitive Robotics
Authors: Botzheim János
Published: June 2021

Recently, various types of intelligent robots have been developed for the society of the next generation [...]
Seasonal Spectral Separation of Western Snowberry and Wolfwillow in Grasslands with Field Spectroradiometer and Simulated Multispectral Bands
Authors: Soubry Irini , Guo Xulin
Published: June 2021

Woody plant encroachment (WPE), the expansion of native and non-native trees and shrubs into grasslands, has led to degradation worldwide. In the Canadian prairies, western snowberry and wolfwillow shrubs are common encroachers, whose cover is currently unknown. As the use of remote sensing in grassland monitoring increases, opportunities to detect and map these woody species are enhanced. Therefore, the purpose of this study is to identify the optimal season for detection of the two shrubs, to determine the sensitive wavelengths and bands that allow for their separation, and to investigate differences in separability potential between a hyperspectral and broadband multispectral approach. We do this by using spring, summer, and fall field-based spectra of both shrubs for the calculation of spectral separability metrics and for the simulation of broadband spectra. Our results show that the summer offers higher discrimination between the two species, especially when using the red and blue spectral regions and to a lesser extent the green region. The fall season fails to provide significant spectral separation along the wavelength spectrum. Moreover, there is no significant difference in the results from the hyperspectral or broadband approach. Nevertheless, cross-validation with satellite imagery is needed to confirm the current results.
Oscillatory Reversible Osmotic Growth of Sessile Saline Droplets on a Floating Polydimethylsiloxane Membrane
Authors: Roy Pritam Kumar , Shoval Shraga , Dombrovsky Leonid A. , Bormashenko Edward
Published: June 2021

We report a cyclic growth/retraction phenomena observed for saline droplets placed on a cured poly (dimethylsiloxane) (PDMS) membrane with a thickness of 7.8 ± 0.1 µm floating on a pure water surface. Osmotic mass transport across the micro-scaled floating PDMS membrane provided the growth of the sessile saline droplets followed by evaporation of the droplets. NaCl crystals were observed in the vicinity of the triple line at the evaporation stage. The observed growth/retraction cycle was reversible. A model of the osmotic mass transfer across the cured PDMS membrane is suggested and verified. The first stage of the osmotic growth of saline droplets is well-approximated by the universal linear relationship, whose slope is independent of the initial radius of the droplet. The suggested physical model qualitatively explains the time evolution of the droplet size. The reported process demonstrates a potential for use in industrial desalination.
Antioxidant, Anti-Obesity, and Anti-Aging Activities of Jeju Citrus Blended Vinegar
Authors: Yun Ye-Rang , Park Bo-Yeon , Kim Sung-Hyun , Jung Ji-Hye
Published: June 2021

Various types of vinegars have been developed as interest in their health benefits has increased. In this study, we prepared Jeju citrus blended vinegars (CBVs) by mixing premature mandarin vinegar and mandarin vinegar, with mandarin vinegar used as a control. The physicochemical properties of the vinegars, including pH, total acidity, and sugar content was determined. Moreover, antioxidant, anti-obesity, and anti-aging activities of the vinegars were investigated. Physicochemical analysis revealed that the CBVs had a pH similar to that of mandarin vinegar, whereas CBVs with relatively high premature mandarin vinegar content showed higher acidity and lower sugar content (p < 0.05). Moreover, the antioxidant activities and phenol contents of CBVs were significantly higher than those of mandarin vinegar (p < 0.05). Meanwhile, CBVs showed significantly decreased intracellular triglyceride, lipid accumulation, and anti-obesity related gene levels (p < 0.05), thereby highlighting their anti-obesity activity. In addition, CBVs showed anti-aging activity by increasing cell viability and cell lifespan, while decreasing the expression of senescence-related genes under H2O2-induced oxidative stress. Therefore, CBVs may be useful as a functional food with antioxidant, anti-obesity, and anti-aging effects in various food fields.
Sulfur-Containing Compounds: Natural Potential Catalyst for the Isomerization of Phytofluene, Phytoene and Lycopene in Tomato Pulp
Authors: Ma Lulu , Yang Cheng , Jiang Xin , Wang Qun , Zhang Jian , Zhang Lianfu
Published: June 2021

The effects of some sulfur-containing compounds on the isomerization and degradation of lycopene, phytofluene, and phytoene under different thermal treatment conditions were studied in detail. Isothiocyanates such as allyl isothiocyanate (AITC) and polysulfides like dimethyl trisulfide (DMTS) had the effect on the configuration of PTF (phytofluene), PT (phytoene), and lycopene. The proportion of their naturally occurring Z-isomers (Z1,2-PTF and 15-Z-PT) decreased and transformed into other isomers including all-trans configuration, while Z-lycopene increased significantly after thermal treatment, especially for 5-Z-lycopene. The results showed that increase in heating temperature, time, and the concentration of DMTS and AITC could promote the isomerization reaction effectively to some extent. In addition, 15-Z-PT and the newly formed Z4-PTF were the predominant isomers in tomato at the equilibrium. Unlike the lycopene, which degraded significantly during heat treatment, the isomers of PTF and PT were stable enough to resist decomposition. Moreover, the isomerization of three carotenoids was enhanced, and the bioaccessibility of lycopene increased significantly with the addition of shii-take mushroom containing sulfur compounds, while there was no positive effect observed in that of PTF and PT.
How Do Patients with Life-Limiting Illness and Caregivers Want End-Of-Life Prognostic Information Delivered? A Pilot Study
Authors: Lewis Ebony T. , Hammill Kathrine A. , Ticehurst Maree , Turner Robin M. , Greenaway Sally , Hillman Ken , Carlini Joan , Cardona Magnolia
Published: June 2021

We aimed to identify the level of prognostic disclosure, type of prognostic information and delivery format of prognostic communication that older adults diagnosed with a life-limiting illness or caregivers prefer to receive. We developed and pilot tested an open-ended survey to 15 older patients and caregivers who had experience in health services for life-limiting illness either for a relative, friend or themselves. Five hypothetical clinical scenarios of prognostic options were presented to ascertain preferences. The preferred format to receive prognostic information was verbal delivery by the clinician with a written summary. Photos and videos were less favoured, and a table with numbers/percentages was least preferred. Distress levels to the prognostic scenarios were low, with the exception of a photo. We conclude that older patients/caregivers want end-of-life prognostic information delivered the traditional way, verbally by clinicians. Options to deliver prognostic information may vary across patient groups but empower clinicians in introducing end-of-life discussions with patients/caregivers. Our study illustrates the feasibility of involving terminal patients and caregivers in research that contributes to eliciting prognostic preferences. Further research is needed to understand whether the prognostic preferences of hospitalized patients with life-limiting illness differ.
Impact of Salinity on the Growth and Chemical Composition of Two Underutilized Wild Edible Greens: Taraxacum officinale and Reichardia picroides
Authors: Alexopoulos Alexios A. , Assimakopoulou Anna , Panagopoulos Panagiotis , Bakea Maria , Vidalis Nikolina , Karapanos Ioannis C. , Petropoulos Spyridon A.
Published: June 2021

Soil salinization is one of the major environmental factors responsible for limited crop production throughout the world. Therefore, there is urgent need to find tolerant/resistant species to exploit in commercial cultivation systems. In this context, the valorization of wild edible greens for human consumption and/or medicinal purposes is gaining more and more interest. The aim of the present work was to study the effect of salinity, e.g., electrical conductivity: 2 mS cm−1 (nutrient solution EC), 6 mS cm−1 and 10 mS cm−1 on plant growth and chemical composition of Reichardia picroides and Taraxacum officinale plants grown in a floating hydroponic system. The results showed that R. picroides is a moderately salt-tolerant species, as the majority of plant growth parameters determined were not negatively affected under the treatment of 6 mS cm−1. On the other hand, the growth parameters of T. officinale plants were severely affected under the same conditions. Moreover, high salinity levels (EC at 10 mS cm−1) impaired the growth of both species. The content of leaves in chlorophylls (a, b and total), carotenoids+xanthophylls and total soluble solids was not significantly affected by the tested EC levels in both species, whereas the titratable acidity increased under the treatment of 10 mS cm−1. Moreover, R. picroides exhibited a more effective adaptation mechanism against saline conditions than T. officinale, as evidenced by the higher accumulation of osmolytes such as proline and the higher shoot K content, probably through a more efficient K/Na selectivity. In conclusion, both species were severely affected by high salinity; however, R. picroides showed promising results regarding its commercial cultivation under moderate salinity levels, especially in regions where resources of high-quality irrigation water are limited.
Review on Performance Evaluation of Autonomous Healing of Geopolymer Composites
Authors: Luhar Salmabanu , Luhar Ismail , Shaikh Faiz Uddin Ahmed
Published: June 2021

It is a universal fact that concrete is one of the most employed construction materials and hence its exigency is booming at a rocket pace, which in turn, has resulted in a titanic demand of ordinary Portland cement. Regrettably, the production of this essential binder of concrete is not merely found to consume restricted natural resources but also found to be associated with emission of carbon dioxide—a primary greenhouse gas (GHG) which is directly answerable to earth heating, resulting in the gigantic dilemma of global warming. Nowadays, in order to address all these impasses, researchers are attracted to innovative Geopolymer concrete technology. However, crack development of various sizes within the concrete is inevitable irrespective of its kind, mix design, etc., owing to external and internal factors viz., over-loading, exposure to severe environments, shrinkage, or error in design, etc., which need to be sealed otherwise these openings permits CO2, water, fluids, chemicals, harmful gases, etc., to pass through reducing service life and ultimately causing the failure of concrete structures in the long term. That is why instant repairs of these cracks are essential, but manual mends are time-consuming and costly too. Hence, self-healing of cracks is desirable to ease their maintenances and repairs. Self-healing geopolymer concrete (SHGPC) is a revolutionary product extending the solution to all these predicaments. The present manuscript investigates the self-healing ability of geopolymer paste, geopolymer mortar, and geopolymer concrete—a slag-based fiber-reinforced and a variety of other composites that endow with multifunction have also been compared, keeping the constant ratio of water to the binder. Additionally, the feasibility of bacteria in a metakaolin-based geopolymer concrete for self-healing the cracks employing Bacteria-Sporosarcina pasteurii, producing Microbial Carbonate Precipitations (MCP), was taken into account with leakage and the healing process in a precipitation medium. Several self-healing mechanisms, assistances, applications, and challenges of every strategy are accentuated, compared with their impacts as a practicable solution of autogenously-healing mechanisms while active concretes are subjected to deterioration, corrosion, cracking, and degradation have also been reviewed systematically.
Role of Physical Activity in Bone–Muscle Crosstalk: Biological Aspects and Clinical Implications
Authors: Cariati Ida , Bonanni Roberto , Onorato Federica , Mastrogregori Ambra , Rossi Danilo , Iundusi Riccardo , Gasbarra Elena , Tancredi Virginia , Tarantino Umberto
Published: June 2021

Bone and muscle tissues influence each other through the integration of mechanical and biochemical signals, giving rise to bone–muscle crosstalk. They are also known to secrete osteokines, myokines, and cytokines into the circulation, influencing the biological and pathological activities in local and distant organs and cells. In this regard, even osteoporosis and sarcopenia, which were initially thought to be two independent diseases, have recently been defined under the term “osteosarcopenia”, to indicate a synergistic condition of low bone mass with muscle atrophy and hypofunction. Undoubtedly, osteosarcopenia is a major public health concern, being associated with high rates of morbidity and mortality. The best current defence against osteosarcopenia is prevention based on a healthy lifestyle and regular exercise. The most appropriate type, intensity, duration, and frequency of exercise to positively influence osteosarcopenia are not yet known. However, combined programmes of progressive resistance exercises, weight-bearing impact exercises, and challenging balance/mobility activities currently appear to be the most effective in optimising musculoskeletal health and function. Based on this evidence, the aim of our review was to summarize the current knowledge about the role of exercise in bone–muscle crosstalk, highlighting how it may represent an effective alternative strategy to prevent and/or counteract the onset of osteosarcopenia.
Design of Cost-Effective and Emission-Aware Power Plant System for Integrated Electric Propulsion Ships
Authors: Nuchturee Chalermkiat , Li Tie , Xia Hongpu
Published: June 2021

Extensive electrification of ship power systems appears to be a promising measure to meet stringent environmental requirements. The concept is to enable ship power management to allocate loads in response to load variations in an optimal manner. From a broader design perspective, the reliability of machinery operation is also of importance, especially with regard to the failure cost from power outages. In this paper, an approach for determining optimal power plants based on economic and environmental perspectives across several architecture choices is proposed. The design procedure involves the implementation of metaheuristic optimization to minimize fuel consumption and emissions released, while maintenance and repair services can be extracted using reliability assessment tools. The simulation results demonstrated that ship power management using the whale optimization algorithm (WOA) was able to reduce fuel consumption and corresponding emissions in a range from 4.04–8.86%, varying with the profiles, by eliminating inefficient working generators and distributing loads for the rest to the nearest possible energy-saving areas. There was also a trade-off between maintenance service and overall system expenses. Finally, a compromise solution was sought with the proposed holistic design for contradictory cost components by taking into account fuel operation consumption, shore electricity supply, maintenance service and investment expenditure.