bluuebunny/crossref_metadata_2025 huggingface dataset:
Refractive Index Measurement of Lithium Ion Battery Electrolyte with Etched Surface Cladding Waveguide Bragg Gratings and Cell Electrode State Monitoring by Optical Strain Sensors
Authors: Nedjalkov Antonio , Meyer Jan , Gräfenstein Alexander , Schramm Benjamin , Angelmahr Martin , Schwenzel Julian , Schade Wolfgang
Published: March 2019

In this scientific publication, a new sensor approach for status monitoring, such as state of charge and state of health, of lithium ion batteries by using special Bragg gratings inscribed into standard optical glass fibers is presented. In addition to well-known core gratings, embedded into the anode of 5 Ah lithium ion pouch cells as a strain monitoring unit, the manufacturing of a surface cladding waveguide Bragg grating sensor incorporated into the cell’s separator, that is sensitive to changes of the refractive index of the surrounding medium, is demonstrated. On the basis of the experiments carried out, characteristics of the cell behavior during standard cyclization and recognizable marks in subsequent post-mortem analyses of the cell components are shown. No negative influence on the cell performance due to the integrated sensors have been observed; however, the results show a clear correlation between fading cell capacity and changes of the interior optical signals. Additionally, with the novel photonic sensor, variations in the electrolyte characteristics are determinable as the refractive index of the solution changes at different molar compositions. Furthermore, with the manufactured battery cells, abuse tests by overcharging were conducted, and it was thereby demonstrated how internal battery sensors can derive additional information beyond conventional battery management systems to feasibly prevent catastrophic cell failures. The result of the research work is an early stage photonic sensor that combines chemical, mechanical and thermal information from inside the cell for an enhanced battery status analysis.
Endogenous Neurostimulation and Physiotherapy in Cluster Headache: A Clinical Case
Authors: Navarro-Fernández Gonzalo , de-la-Puente-Ranea Lucía , Gandía-González Marisa , Gil-Martínez Alfonso
Published: March 2019

Objective: The aim of this paper is to describe the progressive changes of chronic cluster headaches (CHs) in a patient who is being treated by a multimodal approach, using pharmacology, neurostimulation and physiotherapy. Subject: A male patient, 42 years of age was diagnosed with left-sided refractory chronic CH by a neurologist in November 2009. In June 2014, the patient underwent a surgical intervention in which a bilateral occipital nerve neurostimulator was implanted as a treatment for headache. Methods: Case report. Results: Primary findings included a decreased frequency of CH which lasted up to 2 months and sometimes even without pain. Besides this, there were decreased levels of anxiety, helplessness (PCS subscale) and a decreased impact of headache (HIT-6 scale). Bilateral pressure pain thresholds (PPTs) were improved along with an increase in strength and motor control of the neck muscles. These improvements were present at the conclusion of the treatment and maintained up to 4 months after the treatment. Conclusions: A multimodal approach, including pharmacology, neurostimulation and physiotherapy may be beneficial for patients with chronic CHs. Further studies such as case series and clinical trials are needed to confirm these results.
Development of DNA Aptamers to Native EpCAM for Isolation of Lung Circulating Tumor Cells from Human Blood
Authors: Zamay Galina S. , Kolovskaya Olga S. , Ivanchenko Tatiana I. , Zamay Tatiana N. , Veprintsev Dmitry V. , Grigorieva Valentina L. , Garanzha Irina I. , Krat Alexey V. , Glazyrin Yury E. , Gargaun Ana , Lapin Ivan N. , Svetlichnyi Valery A. , Berezovski Maxim V. , Kichkailo Anna S.
Published: March 2019

We selected DNA aptamers to the epithelial cell adhesion molecule (EpCAM) expressed on primary lung cancer cells isolated from the tumors of patients with non-small cell lung cancer using competitive displacement of aptamers from EpCAM by a corresponding antibody. The resulting aptamers clones showed good nanomolar affinity to EpCAM-positive lung cancer cells. Confocal microscopy imaging and spectral profiling of lung cancer tissues confirmed the same protein target for the aptamers and anti-EpCAM antibodies. Furthermore, the resulted aptamers were successfully applied for isolation and detection of circulating tumor cells in clinical samples of peripheral blood of lung cancer patients.
Ruthenium Supported on Ionically Cross-linked Chitosan-Carrageenan Hybrid MnFe2O4 Catalysts for 4-Nitrophenol Reduction
Authors: Liew Kin Hong , Lee Tian Khoon , Yarmo Mohd Ambar , Loh Kee Shyuan , Peixoto Andreia F. , Freire Cristina , Yusop Rahimi M.
Published: March 2019

Herein, we report a facile procedure to synthesize the hybrid magnetic catalyst (Ru@CS-CR@Mn) using ruthenium (Ru) supported on ionically cross-linked chitosan-carrageenan (CS-CR) and manganese ferrite (MnFe2O4) nanoparticles with excellent catalytic activity. The ionic gelation of CS-CR is acting as a protecting layer to promote the encapsulation of MnFe2O4 and Ru nanoparticles by electrostatic interactions. The presence of an active metal and a CS-CR layer on the as-prepared Ru@CS-CR@Mn catalyst was well determined by a series of physicochemical analyses. Subsequently, the catalytic performances of the Ru@CS-CR@Mn catalysts were further examined in the 4-nitrophenol (4-NP) reduction reaction in the presence of sodium borohydride (reducing agent) at ambient temperature. The Ru@CS-CR@Mn catalyst performed excellent catalytic activity in the 4-NP reduction, with a turnover frequency (TOF) values of 925 h−1 and rate constant (k) of 0.078 s−1. It is worth to mentioning that the Ru@CS-CR@Mn catalyst can be recycled and reused up to at least ten consecutive cycles in the 4-NP reduction with consistency in catalytic performance. The Ru@CS-CR@Mn catalyst is particularly attractive as a catalyst due to its superior catalytic activity and superparamagnetic properties for easy separation. We foresee this catalyst having high potential to be extended in a wide range of chemistry applications.
Adaptations in Mitochondrial Enzymatic Activity Occurs Independent of Genomic Dosage in Response to Aerobic Exercise Training and Deconditioning in Human Skeletal Muscle
Authors: Fritzen Andreas M. , Thøgersen Frank B. , Thybo Kasper , Vissing Christoffer R. , Krag Thomas O. , Ruiz-Ruiz Cristina , Risom Lotte , Wibrand Flemming , Høeg Louise D. , Kiens Bente , Duno Morten , Vissing John , Jeppesen Tina D.
Published: March 2019

Mitochondrial DNA (mtDNA) replication is thought to be an integral part of exercise-training-induced mitochondrial adaptations. Thus, mtDNA level is often used as an index of mitochondrial adaptations in training studies. We investigated the hypothesis that endurance exercise training-induced mitochondrial enzymatic changes are independent of genomic dosage by studying mtDNA content in skeletal muscle in response to six weeks of knee-extensor exercise training followed by four weeks of deconditioning in one leg, comparing results to the contralateral untrained leg, in 10 healthy, untrained male volunteers. Findings were compared to citrate synthase activity, mitochondrial complex activities, and content of mitochondrial membrane markers (porin and cardiolipin). One-legged knee-extensor exercise increased endurance performance by 120%, which was accompanied by increases in power output and peak oxygen uptake of 49% and 33%, respectively (p < 0.01). Citrate synthase and mitochondrial respiratory chain complex I–IV activities were increased by 51% and 46–61%, respectively, in the trained leg (p < 0.001). Despite a substantial training-induced increase in mitochondrial activity of TCA and ETC enzymes, there was no change in mtDNA and mitochondrial inner and outer membrane markers (i.e., cardiolipin and porin). Conversely, deconditioning reduced endurance capacity by 41%, muscle citrate synthase activity by 32%, and mitochondrial complex I–IV activities by 29–36% (p < 0.05), without any change in mtDNA and porin and cardiolipin content in the previously trained leg. The findings demonstrate that the adaptations in mitochondrial enzymatic activity after aerobic endurance exercise training and the opposite effects of deconditioning are independent of changes in the number of mitochondrial genomes, and likely relate to changes in the rate of transcription of mtDNA.
Studies of Energy Consumption by a City Bus Powered by a Hybrid Energy Storage System in Variable Road Conditions
Authors: Łebkowski Andrzej
Published: March 2019

This article analyzes various configurations of Hybrid Energy Storage Systems consisting of batteries only, combinations of batteries and supercapacitors, and supercapacitors only. For the presented configurations, mathematical models that were used in research in terms of energy consumption and carbon dioxide emissions were developed, employing a 12-m city bus as a test bed. The tests were carried out using standard test cycles for heavy vehicles as well as routes developed on the basis of actual road conditions. The obtained test results confirmed that the lowest energy consumption is characterized by the system supplied exclusively by batteries (855 Wh/km), followed by a hybrid system of a large battery with a small supercapacitor (941 Wh/km), a hybrid system with a large supercapacitor and a small battery pack (1087 Wh/km), and finally a system with a supercapacitor only (1091 Wh/km). In comparison with the conventional diesel power system (3967 Wh/km), the CO2 emission reductions ranged from 27% to 43%, depending on the source of electrical energy.
An Optimization Study on Soot-Blowing of Air Preheaters in Coal-Fired Power Plant Boilers
Authors: Shi Yuanhao , Wen Jie , Cui Fangshu , Wang Jingcheng
Published: March 2019

This paper presents a comprehensive approach for optimization of soot-blowing of air preheaters in a coal-fired power plant boiler. In the method, modeling of the cleanliness factor is firstly proposed to monitor the ash deposition status of the air preheaters. Then, the statistical fitting of the ash fouling status is subsequently obtained to analyze the ash fouling dynamics and assessment of optimized soot-blowing strategies. Soot-blowing strategies are finally developed to optimize the steam consumption and heat transfer efficiency. Our methods can achieve the fouling monitoring and soot-blowing optimization of air preheater (APH) by using the existing monitoring data, not requiring additional special instruments and complex computing systems. The methodology is validated with the actual operating data of a 300 MW coal-fired power plant boiler. The results show the effectiveness of the proposed method. It can be used for the soot-blowing optimization in most coal-fired power plant boiler with air preheaters.
Leaf Enzyme and Plant Productivity Responses to Environmental Stress Associated with Sea Level Rise in Two Asian Mangrove Species
Authors: Lv Xiaobo , Li Donghai , Yang Xiaobo , Zhang Mengwen , Deng Qin
Published: March 2019

As the only forests situated at the transition between land and sea, mangrove forests are one of the first ecosystems vulnerable to rising sea levels. When the sea level rises, plants are exposed to increased salinity, as well as tidal flooding. The responses of mangrove forests to changing sea levels depend on the synergistic effects of tidal flooding and salinity on plants, especially seedlings. The focus of this paper is to assess the ability of different tide position on mangrove Aegiceras corniculatum (A. corniculatum) and Bruguiera sexangula (B. sexangula) seedlings to withstand tidal flooding and seawater salinity, and to investigate the effects of tidal flooding and salinity on plant growth. To accomplish this, a controlled experiment was initiated to examine the synergistic effects of tidal flooding and salinity on the growth and physiology of A. corniculatum and B. sexangula seedlings subjected to four tidal flooding times and four levels of salinity over a course of six months. The results showed that the biomass and antioxidant enzymes of A. corniculatum and B. sexangula seedlings were significantly affected by the increase in salinity and flooding time. Changes in biomass, SOD, and CAT activity of A. corniculatum seedlings show that they are more adapted to grow in an environment with high salinity and long flooding time than B. sexangula. Our results show that species growing in middle- to low-tide levels were better adapted to sea level rise than those growing at high-tide levels.
How the American Working Class Views the “Working Class”
Authors: Thelin William H.
Published: March 2019

This article reviews the complications in understanding some of the conflicting tenets of American working-class ethos, especially as it unfolds in the college classroom. It asserts that the working class values modesty, straightforwardness, and hard work and has a difficult time accepting an ethos based in formal education. The article also discusses some of the performance aspects of working-class texts and explores the difficulties that outsiders face in trying to analyze/critique working-class experience.
Body Fluids and Fluid Bodies: Trans-Corporeal Connections in Contemporary German Narratives of Illness
Authors: Herges Katja
Published: March 2019

Medicine uses body fluids for the construction of medical knowledge in the laboratory and at the same time considers them as potentially infectious or dirty. In this model, bodies are in constant need of hygienic discipline if they are to adhere to the ideal of the closed and clean organism without leakage of fluids. In contrast, psychoanalytical feminist body theory by Julia Kristeva (1982), Elisabeth Grosz (1989) and Margrit Shildrick (1999) has deconstructed the abject body and its fluids in Western culture and medicine. While postmodern feminism has often focused on discourses about bodies and illness to the neglect of their materiality, more recently, material feminism has drawn particular attention to lived material bodies with fluid boundaries and evolving corporeal practices (Alaimo and Hekman 2007). Stacy Alaimo has developed a model of the trans-corporeal body that is connected with the environment through fluid boundaries and exchanges (2010, 2012). Influenced by these trends in feminist body theory, illness narratives, often based on autobiographical experiences of female patients or their caregivers, have increased in recent decades in the West (Lorde 1980; Mairs 1996; Stefan 2007; Schmidt 2009; Hustvedt 2010). Such narratives often describe explicitly the material and affective aspects of intimate bodily experiences. In this article, I analyze two German quest narratives of illness: Charlotte Roche’s pop novel Feuchtgebiete (2008) and Detlev Buck’s German-Cambodian film Same Same But Different (2010) that is based on the memoir Wohin Du auch gehst by German journalist Benjamin Prüfer (2007). In both narratives, the protagonists and their partners struggle in their search for love and identity with illness or injury in relation to body fluids, including hemorrhoids and HIV. I argue that Feuchtgebiete and Same Same But Different not only critique medical and cultural discourses on body (fluids) and sexuality but also foreground a feminist trans-corporeal concept of the body and of body fluids that is open to fluid identities and material connections with the (global) environment. At the same time, the conventional and sentimental ending of these quest narratives undermines the possibilities of the trans-corporeal body and its fluid exchanges.
Pharmacokinetic and Metabolomic Studies with BIO 300, a Nanosuspension of Genistein, in a Nonhuman Primate Model
Authors: Cheema Amrita K. , Mehta Khyati Y. , Santiago Paola T. , Fatanmi Oluseyi O. , Kaytor Michael D. , Singh Vijay K.
Published: March 2019

Genistein is a naturally occurring phytoestrogen isoflavone and is the active drug ingredient in BIO 300, a radiation countermeasure under advanced development for acute radiation syndrome (H-ARS) and for the delayed effects of acute radiation exposure (DEARE). Here we have assessed the pharmacokinetics (PK) and safety of BIO 300 in the nonhuman primate (NHP). In addition, we analyzed serum samples from animals receiving a single dose of BIO 300 for global metabolomic changes using ultra-performance liquid chromatography (UPLC) quadrupole time-of-flight mass spectrometry (QTOF-MS). We present a comparison of how either intramuscularly (im) or orally (po) administered BIO 300 changed the metabolomic profile. We observed transient alterations in phenylalanine, tyrosine, glycerophosphocholine, and glycerophosphoserine which reverted back to near-normal levels 7 days after drug administration. We found a significant overlap in the metabolite profile changes induced by each route of administration; with the po route showing fewer metabolic alterations. Taken together, our results suggest that the administration of BIO 300 results in metabolic shifts that could provide an overall advantage to combat radiation injury. This initial assessment also highlights the utility of metabolomics and lipidomics to determine the underlying physiological mechanisms involved in the radioprotective efficacy of BIO 300.
Phylogeography of the Assassin Bug Sphedanolestes impressicollis in East Asia Inferred From Mitochondrial and Nuclear Gene Sequences
Authors: Du Zhenyong , Ishikawa Tadashi , Liu Hui , Kamitani Satoshi , Tadauchi Osamu , Cai Wanzhi , Li Hu
Published: March 2019

The assassin bug, Sphedanolestes impressicollis (Hemiptera: Reduviidae), is widely distributed in East Asia. It is an ideal model for evaluating the effects of climatic fluctuation and geographical events on the distribution patterns of East Asian reduviids. Here, we used two mitochondrial genes and one nuclear gene to investigate the phylogeographic pattern of the assassin bug based on comprehensive sampling in China, Japan, South Korea, Vietnam, and Laos. High levels of genetic differentiation were detected among the geographic populations classified into the northern and southern groups. A significant correlation was detected between genetic and geographical distances. The East China Sea land bridge served as a “dispersal corridor” during Pleistocene glaciation. The estimated divergence time indicated that the northern group may have separated from the eastern Chinese populations when the sea level rapidly rose during the “Ryukyu Coral Sea Stage” and the East China Sea land bridge was completely submerged. Demographic history and ecological niche modeling suggested that appropriate climatic conditions may have accounted for the rapid spread across the Korean Peninsula and Japan during the late Pleistocene. Our study underscores the pivotal roles of the Pleistocene sea level changes and climatic fluctuations in determining the distribution patterns of East Asian reduviids.
The Role of Curcumin in the Modulation of Ageing
Authors: Bielak-Zmijewska Anna , Grabowska Wioleta , Ciolko Agata , Bojko Agnieszka , Mosieniak Grażyna , Bijoch Łukasz , Sikora Ewa
Published: March 2019

It is believed that postponing ageing is more effective and less expensive than the treatment of particular age-related diseases. Compounds which could delay symptoms of ageing, especially natural products present in a daily diet, are intensively studied. One of them is curcumin. It causes the elongation of the lifespan of model organisms, alleviates ageing symptoms and postpones the progression of age-related diseases in which cellular senescence is directly involved. It has been demonstrated that the elimination of senescent cells significantly improves the quality of life of mice. There is a continuous search for compounds, named senolytic drugs, that selectively eliminate senescent cells from organisms. In this paper, we endeavor to review the current knowledge about the anti-ageing role of curcumin and discuss its senolytic potential.
Characterization of Stackebrandtia nassauensis GH 20 Beta-Hexosaminidase, a Versatile Biocatalyst for Chitobiose Degradation
Authors: Wang Meng , Zheng Feng , Wang Ting , Lyu Yong-Mei , Alteen Matthew G. , Cai Zhi-Peng , Cui Zhong-Li , Liu Li , Voglmeir Josef
Published: March 2019

An unstudied β-N-acetylhexosaminidase (SnHex) from the soil bacterium Stackebrandtia nassauensis was successfully cloned and subsequently expressed as a soluble protein in Escherichia coli. Activity tests and the biochemical characterization of the purified protein revealed an optimum pH of 6.0 and a robust thermal stability at 50 °C within 24 h. The addition of urea (1 M) or sodium dodecyl sulfate (1% w/v) reduced the activity of the enzyme by 44% and 58%, respectively, whereas the addition of divalent metal ions had no effect on the enzymatic activity. PUGNAc (O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino-N-phenylcarbamate) strongly inhibited the enzyme in sub-micromolar concentrations. The β-N-acetylhexosaminidase was able to hydrolyze β1,2-linked, β1,3-linked, β1,4-linked, and β1,6-linked GlcNAc residues from the non-reducing end of various tested glycan standards, including bisecting GlcNAc from one of the tested hybrid-type N-glycan substrates. A mutational study revealed that the amino acids D306 and E307 bear the catalytically relevant side acid/base side chains. When coupled with a chitinase, the β-N-acetylhexosaminidase was able to generate GlcNAc directly from colloidal chitin, which showed the potential of this enzyme for biotechnological applications.
Ginsenoside Rh2 Ameliorates Doxorubicin-Induced Senescence Bystander Effect in Breast Carcinoma Cell MDA-MB-231 and Normal Epithelial Cell MCF-10A
Authors: Hou Jin-Gang , Jeon Byeong-Min , Yun Yee-Jin , Cui Chang-Hao , Kim Sun-Chang
Published: March 2019

The anthracycline antibiotic doxorubicin is commonly used antineoplastic drug in breast cancer treatment. Like most chemotherapy, doxorubicin does not selectively target tumorigenic cells with high proliferation rate and often causes serve side effects. In the present study, we demonstrated the cellular senescence and senescence associated secretory phenotype (SASP) of both breast tumor cell MDA-MB-231 and normal epithelial cell MCF-10A induced by clinical dose of doxorubicin (100 nM). Senescence was confirmed by flattened morphology, increased level of beta galactose, accumulating contents of lysosome and mitochondrial, and elevated expression of p16 and p21 proteins. Similarly, SASP was identified by highly secreted proteins IL-6, IL-8, GRO, GM-CSF, MCP-1, and MMP1 by antibody array assay. Reciprocal experiments, determined by cell proliferation and apoptosis assays and cell migration and cell invasion, indicated that SASP of MDA-MB-231 cell induces growth arrest of MCF-10A, whereas SASP of MCF-10A significantly stimulates the proliferation of MDA-MB-231. Interestingly, SASP from both cells powerfully promotes the cell migration and cell invasion of MDA-MB-231 cells. Treatment with the natural product ginsenoside Rh2 does not prevent cellular senescence or exert senolytic. However, SASP from senescent cells treated with Rh2 greatly attenuated the above-mentioned bystander effect. Altogether, Rh2 is a potential candidate to ameliorate this unwanted chemotherapy-induced senescence bystander effect.
Comparable Genomic Copy Number Aberrations Differ across Astrocytoma Malignancy Grades
Authors: Pećina-Šlaus Nives , Kafka Anja , Gotovac Jerčić Kristina , Logara Monika , Bukovac Anja , Bakarić Robert , Borovečki Fran
Published: March 2019

A collection of intracranial astrocytomas of different malignancy grades was analyzed for copy number aberrations (CNA) in order to identify regions that are driving cancer pathogenesis. Astrocytomas were analyzed by Array Comparative Genomic Hybridization (aCGH) and bioinformatics utilizing a Bioconductor package, Genomic Identification of Significant Targets in Cancer (GISTIC) 2.0.23 and DAVID software. Altogether, 1438 CNA were found of which losses prevailed. On our total sample, significant deletions affected 14 chromosomal regions, out of which deletions at 17p13.2, 9p21.3, 13q12.11, 22q12.3 remained significant even at 0.05 q-value. When divided into malignancy groups, the regions identified as significantly deleted in high grades were: 9p21.3; 17p13.2; 10q24.2; 14q21.3; 1p36.11 and 13q12.11, while amplified were: 3q28; 12q13.3 and 21q22.3. Low grades comprised significant deletions at 3p14.3; 11p15.4; 15q15.1; 16q22.1; 20q11.22 and 22q12.3 indicating their involvement in early stages of tumorigenesis. Significantly enriched pathways were: PI3K-Akt, Cytokine-cytokine receptor, the nucleotide-binding oligomerization domain (NOD)–like receptor, Jak-STAT, retinoic acid-inducible gene (RIG)-I-like receptor and Toll-like receptor pathways. HPV and herpex simplex infection and inflammation pathways were also represented. The present study brings new data to astrocytoma research amplifying the wide spectrum of changes that could help us identify the regions critical for tumorigenesis.
Effects of Eleutherococcus Extract Mixture on Endochondral Bone Formation in Rats
Authors: Lee Donghun , Lee Sung Hyun , Cho Namhoon , Kim Young-Sik , Song Jungbin , Kim Hocheol
Published: March 2019

Eleutherococcus extract mixture (EEM) is an herbal mixture of dried stem of Eleutherococcus sessiliflorus and germinated barley, which has been highly effective, in previous screening and among the traditional medicines to tonify innate qi and acquired qi, respectively. In this study, we investigate the effects of EEM on endochondral bone formation. Female adolescent rats were given EEM, growth hormone or vehicle for 10 days. Tetracycline was intraperitoneally injected to light the fluorescent band 72 h before sacrifice to determine endochondral bone formation. In order to evaluate endocrine or paracrine/autocrine mechanisms, expressions of insulin-like growth factor 1 (IGF1), insulin-like growth factor binding protein 3 (IGFBP3), or bone morphogenetic protein 2 (BMP2) were evaluated after EEM administration in liver or growth plate (GP). EEM oral administration significantly increased endochondral bone formation and proliferative and hypertrophic zonal heights of tibial GP. EEM also upregulated hepatic IGF1 and IGFBP3 mRNA expressions, and IGF1 and BMP2 expressions in GP. Taken together, EEM increases endochondral bone formation through stimulating proliferation and hypertrophy with upregulation of hepatic IGF1 and IGFBP3 expressions. Considering immunohistochemical studies, the effect of EEM may be due to increased local IGF1 and BMP2 expression in GP, which may be considered growth hormone (GH)-dependent endocrine and autocrine/paracrine pathways.
Current Advances in Palliative & Hospice Care: Problems and Needs of Relatives and Family Caregivers During Palliative and Hospice Care—An Overview of Current Literature
Authors: Oechsle Karin
Published: March 2019

Palliative and hospice care aims to improve quality of life of patients’ relatives, but still little is known about their specific problems and needs. We present a comprehensive literature update. Narrative review to present an expert overview of peer-reviewed, English-written original research publications and reviews on psychosocial and existential problems, supportive needs as well as interventions for relatives during the patients’ disease trajectory published between January 2017 and November 2018. A total of 64 publications were included. Relatives report high rates of psychological and existential distress, burden and psychological morbidity during the total disease trajectory of the patient. In addition, relatives report an alarmingly high number of unmet needs with information being the central issue. Relatives’ problems and needs are part of complex systems influenced by various socio-demographic factors and patient–relatives-interactions and dependency between different psychological phenomena. First support interventions for relatives during disease trajectory have proven feasible and secondary data from randomized studies suggest beneficial effects of providing early palliative care also for relatives. Relatives should be addressed to a still larger extent in the daily practice of palliative and hospice care, thus further research to reveal more detailed systematic information is needed to improve relatives’ psychological burden and quality of life.
Effects of Fe3P Addition on Sintering Behaviors and Magnetic Properties of Fe-P Alloys Sintered at Low Temperatures
Authors: Ma Rui , Yu Kaiping , Liu Litao , Jiang Heng , Ye Shulong , Yu Peng
Published: March 2019

In this paper, we demonstrate that trace amounts of P addition can activate the sintering of carbonyl powder and influence the magnetic properties of the sintered materials. Fe-x P (x = 0, 0.6, 0.8, 1.0, 1.2, 1.4, and 1.6 wt.%) samples were fabricated by doping carbonyl powder with different amounts of Fe3P. They were sintered at 1000 °C in argon for 2 h. The sintering of the Fe-0 wt.% P sample was interrupted by the ferrite-austenite transformation at 912 °C due to the low diffusion rate of the austenite. The addition of P can stabilize the ferrite, and suppress the ferrite-austenite transformation. Therefore, all the P-containing samples shrank continuously throughout the whole sintering process, which showed improved sintering densities compared to the P-free sample. However, the sintering density did not increase monotonously with increasing P content. The Fe-1.4 wt.% P and Fe-1.6wt.% P samples easily got oxidized during sintering, and the densification process was thus influenced by the P-containing oxide particles. As a result, the Fe-1.2 wt.% P sample exhibited the highest sintering density (7.664 g/cm3) and the best magnetic properties (coercive force 172 A/m).
Fatigue Life Prediction of Steam Generator Tubes by Tube Specimens with Circular Holes
Authors: Wang Qiwei , Chen Junfeng , Chen Xiao , Gao Zengliang , Li Yuebing
Published: March 2019

Heat exchangers manufactured from Inconel 690 tubes are widely used for steam generators in nuclear power plants. Inconel 690 tubes have suffered failures of fatigue fracture due to flow induced vibration. It is difficult to obtain the fatigue life of the tube directly since the conventional fatigue test would potentially cause end fatigue failure due to the stress concentration at the clamp end. In this study, a thin-walled Inconel 690 tube with circular hole is designed to deduce the fatigue life of smooth tube based on the notch fatigue life prediction technology. Firstly, the local stress and strain distributions around the hole based on the finite element analysis are discussed. Local stress-strain is calculated and compared with Neuber’s ruler. Meanwhile, fatigue life tests using tube specimens with circular holes are carried out. Finally, based on the best-fitted fatigue life curve of Inconel 690 alloy, the fatigue life of tube specimen is estimated from the local strain according to Neuber’s ruler. The results show that the local stress and strain estimated by Neuber’s ruler are basically consistent with those obtained by finite element analysis. Compared with the average fatigue life of nickel-based alloy, the new predicted equivalent fatigue life of heat Inconel 690 transfer tube with a hole is higher. The Inconel 690 heat transfer tube has better fatigue performance.
Terahertz and Photoelectron Emission from Nanoporous Gold Films on Semiconductors
Authors: Nan Junyi , Li Min , Zhang Ling , Yuan Shuai , He Boqu , Zeng Heping
Published: March 2019

Efficient terahertz and photoelectron emission were observed from nano-porous gold (NPG) films deposited on an intrinsic gallium arsenide (GaAs) semiconductor substrate stimulated by femtosecond laser with pulse width of 60 fs. Time-domain THz emission and reflection spectroscopy confirmed that the free charges accelerated by irradiated femtosecond laser pulses transferred from the NPG films into the GaAs substrates. Accordingly, charges accumulation was reduced in the NPG films, resulting in a stronger emission of THz pulse than that from NPG films deposited on SiO2 substrate. Charges injected into the GaAs substrate enforced an observable decrease of the THz refractive index proportional to the intensity of incident light. In comparison, for NPG deposited on glass substrates, laser induced free charges were accumulated in the NPG films, and femtosecond laser pulses irradiating on the NPG films made no changes of the THz refractive index of the glass substrates.
Near-Infrared Surface-Enhanced Raman Scattering on Silver-Coated Porous Silicon Photonic Crystals
Authors: Škrabić Marko , Kosović Marin , Gotić Marijan , Mikac Lara , Ivanda Mile , Gamulin Ozren
Published: March 2019

Surface-enhanced Raman scattering (SERS) with near-infrared (NIR) excitation offers a safe way for the detection and study of fragile biomolecules. In this work, we present the possibility of using silver-coated porous silicon photonic crystals as SERS substrates for near-infrared (1064 nm) excitation. Due to the deep penetration of NIR light inside silicon, the fabrication of photonic crystals was necessary to quench the band gap photoluminescence of silicon crystal, which acts as mechanical support for the porous layer. Optimal parameters of the immersion plating process that gave maximum enhancement were found and the activity of SERS substrates was tested using rhodamine 6G and crystal violet dye molecules, yielding significant SERS enhancement for off-resonant conditions. To our knowledge, this is the first time that the 1064 nm NIR laser excitation is used for obtaining the SERS effect on porous silicon as a substrate.
The MicroRNA miR-155 Is Essential in Fibrosis
Authors: Eissa Mousa G. , Artlett Carol M.
Published: March 2019

The function of microRNAs (miRNAs) during fibrosis and the downstream regulation of gene expression by these miRNAs have become of great biological interest. miR-155 is consistently upregulated in fibrotic disorders, and its ablation downregulates collagen synthesis. Studies demonstrate the integral role of miR-155 in fibrosis, as it mediates TGF-β1 signaling to drive collagen synthesis. In this review, we summarize recent findings on the association between miR-155 and fibrotic disorders. We discuss the cross-signaling between macrophages and fibroblasts that orchestrates the upregulation of collagen synthesis mediated by miR-155. As miR-155 is involved in the activation of the innate and adaptive immune systems, specific targeting of miR-155 in pathologic cells that make excessive collagen could be a viable option before the depletion of miR-155 becomes an attractive antifibrotic approach.
Effects of Fresh Watermelon Consumption on the Acute Satiety Response and Cardiometabolic Risk Factors in Overweight and Obese Adults
Authors: Lum Tiffany , Connolly Megan , Marx Amanda , Beidler Joshua , Hooshmand Shirin , Kern Mark , Liu Changqi , Hong Mee Young
Published: March 2019

Although some studies have demonstrated the beneficial effects of watermelon supplementation on metabolic diseases, no study has explored the potential mechanism by which watermelon consumption improves body weight management. The objective of this study was to evaluate the effects of fresh watermelon consumption on satiety, postprandial glucose and insulin response, and adiposity and body weight change after 4 weeks of intervention in overweight and obese adults. In a crossover design, 33 overweight or obese subjects consumed watermelon (2 cups) or isocaloric low-fat cookies daily for 4 weeks. Relative to cookies, watermelon elicited more (p < 0.05) robust satiety responses (lower hunger, prospective food consumption and desire to eat and greater fullness). Watermelon consumption significantly decreased body weight, body mass index (BMI), systolic blood pressure and waist-to-hip ratio (p ≤ 0.05). Cookie consumption significantly increased blood pressure and body fat (p < 0.05). Oxidative stress was lower at four week of watermelon intervention compared to cookie intervention (p = 0.034). Total antioxidant capacity increased with watermelon consumption (p = 0.003) in blood. This study shows that reductions in body weight, body mass index (BMI), and blood pressure can be achieved through daily consumption of watermelon, which also improves some factors associated with overweight and obesity (clinicaltrials.gov, NCT03380221).
Increasing Chocolate’s Sugar Content Enhances Its Psychoactive Effects and Intake
Authors: Casperson Shanon L. , Lanza Lisa , Albajri Eram , Nasser Jennifer A.
Published: March 2019

Chocolate elicits unique brain activity compared to other foods, activating similar brain regions and neurobiological substrates with potentially similar psychoactive effects as substances of abuse. We sought to determine the relationship between chocolate with varying combinations of its main constituents (sugar, cocoa, and fat) and its psychoactive effects. Participants consumed 5 g of a commercially available chocolate with increasing amounts of sugar (90% cocoa, 85% cocoa, 70% cocoa, and milk chocolates). After each chocolate sample, participants completed the Psychoactive Effects Questionnaire (PEQ). The PEQ consists of questions taken from the Morphine-Benzedrine Group (MBG), Morphine (M,) and Excitement (E) subscales of the Addiction Research Center Inventory. After all testing procedures, participants completed the Binge Eating Scale (BES) while left alone and allowed to eat as much as they wanted of each of the different chocolates. We found a measurable psychoactive dose–effect relationship with each incremental increase in the chocolate’s sugar content. The total number of positive responses and the number of positive responses on the E subscale began increasing after tasting the 90% cocoa chocolate, whereas the number of positive responses on the MBG and M subscales began increasing after tasting the 85% cocoa chocolate sample. We did not find a correlation between BES scores and the total amount of chocolate consumed or self-reported scores on the PEQ. These results suggest that each incremental increase in chocolate’s sugar content enhances its psychoactive effects. These results extend our understanding of chocolate’s appeal and unique ability to prompt an addictive-like eating response.
The Effect of an Infant Formula Supplemented with AA and DHA on Fatty Acid Levels of Infants with Different FADS Genotypes: The COGNIS Study
Authors: Salas Lorenzo Isabel , Chisaguano Tonato Aida M. , de la Garza Puentes Andrea , Nieto Ana , Herrmann Florian , Dieguez Estefanía , Castellote Ana I. , López-Sabater M. Carmen , Rodríguez-Palmero Maria , Campoy Cristina
Published: March 2019

Polymorphisms in the fatty acid desaturase (FADS) genes influence the arachidonic (AA) and docosahexaenoic (DHA) acid concentrations (crucial in early life). Infants with specific genotypes may require different amounts of these fatty acids (FAs) to maintain an adequate status. The aim of this study was to determine the effect of an infant formula supplemented with AA and DHA on FAs of infants with different FADS genotypes. In total, 176 infants from the COGNIS study were randomly allocated to the Standard Formula (SF; n = 61) or the Experimental Formula (EF; n = 70) group, the latter supplemented with AA and DHA. Breastfed infants were added as a reference group (BF; n = 45). FAs and FADS polymorphisms were analyzed from cheek cells collected at 3 months of age. FADS minor allele carriership in formula fed infants, especially those supplemented, was associated with a declined desaturase activity and lower AA and DHA levels. Breastfed infants were not affected, possibly to the high content of AA and DHA in breast milk. The supplementation increased AA and DHA levels, but mostly in major allele carriers. In conclusion, infant FADS genotype could contribute to narrow the gap of AA and DHA concentrations between breastfed and formula fed infants.
Studying a Flexible Polyurethane Elastomer with Improved Impact-Resistant Performance
Authors: Fan Jitang , Chen Ang
Published: March 2019

A flexible polyurethane elastomer (PUE) is studied, and the improved impact-resistant performance is revealed. Compressive stress–strain curves over a wide loading rate range were derived. Under static loading, the rubbery-like characteristics are demonstrated, which are flexible and hyperelastic, to process a large strain of about 60% followed by full recovery upon unloading. Under high-rate loadingcompared with the mechanical data of polyurethane elastomer (PUE) and polyurea (PUA) materials in the literature. Orderly parallel deformation bands were formed from carrying a large strain. The fibrils were found between deformation bands for enhancing the yield/plateau stress. A considerable plastic zone ahead of propagating crack with numerous crazes and microcracks was produced for realizing the dynamic strain energy absorption. This work presents a scientific innovation for developing outstanding impact-resistant polyurethane elastomers for transparent protection engineering.
Preparation and Properties of Polyvinylidene Fluoride Nanocomposited Membranes based on Poly(N-Isopropylacrylamide) Modified Graphene Oxide Nanosheets
Authors: Meng Xiangli , Ji Yuan , Yu Genhua , Zhai Yujia
Published: March 2019

The nanomaterial of graphene oxide grafting poly (N-isopropylacrylamide) (GO-g-PNIPAAm) was synthesized and PVDF/GO-g-PNIPAAm blended membranes were fabricated by wet phase inversion. In this work, a hydrophilic nanomaterial GO-g-PNIPAAm with poly(N-isopropylacrylamide) (PNIPAAm) grafted on GO, was synthesized by the atom transfer radical polymerization (ATRP) method. The resulting nanomaterial was confirmed by scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FTIR), Raman spectrum, and X-ray photoelectron spectroscopy (XPS) analysis. The synthesized GO-g-PNIPAAm was incorporated with polyvinylidene fluoride (PVDF) via phase inversion, and investigated for its temperature sensitivity, porosity, contact angle, scanning electron microscopy, and permeate properties. The water contact angle measurements confirmed that GO-g-PNIPAAm nanomaterial-endowed PVDF membranes with better hydrophilicity and thermo-responsive properties compared with those of the pristine PVDF membranes. Bovine serum albumin (BSA) adsorption experiments suggested that excellent antifouling properties of membranes were acquired after adding GO-g-PNIPAAm. The modified membranes showed good performance when the doping amount of GO-g-PNIPAAm was 0.2 wt %.
Nutrition and Physical Activity for Pre-Schoolers: Knowledge and Perspectives amongst Early Childhood Education Teachers
Authors: Rapson Jeanette , Conlon Cath , Ali Ajmol
Published: March 2019

Background: Caregivers’ knowledge of the links between nutrition, diet and physical activity isrecognised as important for children’s health and body size [...]
Sugar Sweetened Beverage Consumption in Auckland Primary School Children
Authors: Smirk Emma , Conlon Cathryn , Beck Kathryn , Gammon Cheryl , Hurst Pamela von
Published: March 2019

Background: Sugar sweetened beverage (SSB) consumption has a positive relationship withunhealthy weight gain in children [...]
The Accessibility and Understanding of Nutrition Advice in First Time Mothers
Authors: Sisson Caitlin , Choukri Maria Anna
Published: March 2019

Background: Nutrition is vital to achieve optimal health outcomes for both mother and babyduring pregnancy [...]
Contemporary Misticism: Recovering Sensible Aesthetics in an Age of Digital Production
Authors: Van Schepen Randall K.
Published: March 2019

Materialist accounts of artistic development emphasize the ongoing revolution of media in the progress of history. Amongst the most popular accounts of modernity are Walter Benjamin’s essays on the relationship of photography to traditional art. His account of the loss of aura has been subject to countless reinterpretations since its publication. The present essay addresses the contemporary production of a number of architects and artists whose work provides an interesting challenge to the Benjaminian account of the secularization of artistic ritual. The artists Adam Fuss, Vera Lutter, Alison Rossiter, Sally Mann, and others have recently been exploring photographic methods that contradict the Benjaminian account of the history of photography. They continue to explore techniques that Benjamin placed in the auratic pre-paper-print era, such as Daguerreotypes and photograms, as well as employing other more material/chemically based effects. Such artistic choices are often considered nothing more than a nostalgic reverie trying to stem the tide of materialist history, a flawed search for a lost aura of presence. However, when these works are set against the backdrop of contemporary digitized production and of the Dusseldorf School as well as most other contemporary photographers, these “retro” works stand as a critical counterpoint to our present seamless digital imperium. The soft and hazy effects of these works, what I am calling their misticism, occludes the particularity of digital bits of information in a search to connect to the material and the sensual, something denied by information-saturated technologies. Even within a materialist approach to history, there is room to view these architectural and artistic effects as critically productive rather than merely retrograde. The present essay argues for the timely relevance of contemporary retro-photographic techniques in fostering both a critical attitude and as evidence of attempts to recover a sense of spiritual presence.
Dissecting and Interpreting a Three-Dimensional Ground-Penetrating Radar Dataset: An Example from Northern Australia
Authors: Conyers Lawrence B. , Sutton Mary-Jean , St. Pierre Emma
Published: March 2019

A robust 3-D GPR dataset provides interpreters with a variety of methods for extracting important information at buried archaeological sites. An iterative approach that uses reflection profile analysis, amplitude slice-mapping, and often both in conjunction is often necessary as neither method by itself is sufficient. In northern Australia, two constructed mounds contain a number of cultural and geological horizons and features, which can be imaged with GPR. The reflection profiles display the modified ground surface prior to mound construction and some initial construction layers. On the pre-mound surface, amplitude maps of reflective layers that were built-up on the ground surface indicate that they were constructed in an intentional manner. Those surfaces were later covered by sand to produce mounds used for human burial. Human internments in the mound can only be seen in reflection profiles, but once discovered, the profiles can be re-sliced to produce high definition amplitude images of these remains. No one method of analysis can provide an overall interpretation of these complex internal mound features. When the methods are varied, depending on the results of one method, a detailed and varied analysis of certain aspects of the mounds’ internal features are visible, leading to the generation of a number of hypotheses about how this area of northern Australia was used in the past. The 3-D data from GPR shows that this area was an important location on the landscape in the past, and was modified by the construction of a monumental mound, which was then used for human burials, and more recently, the construction of what was likely a ritual enclosure.