bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Organ-Organ Pendukung Good Corporate Governance Terhadap Tax Avoidance
Authors: Utami Rafika Putri , Syafiqurrahman Muhammad
Published: July 2019

This study aims to analyze the influence of the parts of a supporter of good corporate governance and audit committee, remuneration committee, external audit and management of risks to tax avoidance. Tax avoidance in this study measured by book tax difference. The sample of this study were 198 manufacturing companies listed in BEI in 2012-2014. The sample was chosen by method purposive sampling. Test regression analysis shows that statistically significant proved is the audit committee, audit external program, and risk management to tax avoidance.

 

Penelitian ini bertujuan untuk menganalisis pengaruh organ-organ pendukung good corporate governance yaitu komite audit, komite remunerasi, eksternal audit dan manajemen risiko terhadap tax avoidance. Tax  avoidance  pada penelitian ini diukur dengan Book Tax Difference (BTD). Sampel penelitian ini adalah 198 perusahaan manufaktur yang terdaftar di BEI tahun 2012-2014. Sampel penelitian dipilih dengan metode purposive sampling. Hasil uji analisis regresi  menunjukkan  bahwa secara statistik terbukti terdapat pengaruh signifikan komite audit, eksternal   audit  dan  manajemen  risiko terhadap tax avoidance.
KUALITAS LAPORAN KEUANGAN DAN KEPERCAYAAN STAKEHOLDER (Studi Pada Satuan Kerja Wilayah Kerja KPPN Mataram)
Authors: Arifin Muhammad Naufal , Handajani Lillik , H Alamsyah
Published: July 2019

 

This study is intended to examine empirically influence of competency of human resource, roles of internal auditor, application of SAP, implementation of IT, and SPI towards quality of financial statement.  Furthermore, it also examines influence of trust of stakeholders, and roles of GGG as moderating variables. This research involves 53 organizational units of KPPN Mataram, which acquired WDP (qualified opinion) and TMP (disclaimer of opinion). Data is acquired through questionnaire. Findings of this study indicated that competency of human resources, application of IT and SPI affect positively towards quality of financial statements. Meanwhile, roles of internal auditor and implementation of SAP do not affect significantly.  In addition, quality of financial statements affect trust of stakeholders, but GGG is not able to act as moderating variable between quality of financial statements and trust of stakeholders. Implication of this study is that quality of financial statement can be improved by enhancing competency of human resources as the first step of realization transparency and accountability of financial statement.
REFLECTION OF PHILOSOPHICAL FOUNDATIONS IN FINANCIAL ACCOUNTING RESEARCH
Authors: Nugrahanti Yeterina Widi
Published: July 2019

Current financial accounting research has paid little attention to the philosophical aspects that underlie the research, Hence, the existing results provide a little contribution towards the development of accounting theory and concepts. This article aims to describe the philosophical basis in financial accounting research, which consists of ontology, epistemology and axiology. The ontology and epistemology assumptions determine research paradigm, which are functionalist, interpretive and critical (radical humanist and radical structuralist). The ontology and epistemology assumptions also define the research methodology. This article outlines the taxonomy of financial accounting research formulated by Hopper and Powel (1985) and Laughlin (1995) which can be used as a guide in conducting financial accounting research. Understanding of philosophical aspects will result in high quality financial accounting research.
Transcriptome Analysis Reveals the Symbiotic Mechanism of Ustilago esculenta induced Gall formation of Zizania latifolia
Authors: Li Jie , Lu Zhiyuan , Yang Yang , Guan Yuanlin , Hou Jinfeng , Yuan Lingyun , Chen Guohu , Wang Chenggang , Jia Shaoke , Feng Xuming , Zhu Shidong
Published: July 2019

Background: Zizania latifolia is a perennial aquatic vegetable due to the establishment of symbiosis between Z. latifolia and U. esculenta results in the swelling gall formation. However, the mechanism of symbiosis for the gall formation in U. esculenta infected Z. latifolia is still unclear. To understand the mechanism of symbiosis for the gall formation in U. esculenta infected Z. latifolia, we analyzed Z. latifolia and U. esculenta symbiotic circumstances using Triadimefon (TDF) treatment and RNA-seq technique.

Results: In this present study, 4 different samples were induced under gall before and after formation of CK and TDF treatment in Z. latifolia. Whole growth cycles were recorded and microstructure observation showed that the presence of U. esculenta could be clearly observed after the gall formation, after TDF treatment were not found U. esculenta. A total of 17541 differentially expressed genes (DEGs) were identified based on transcriptome. Meanwhile, GO term and KEGG pathway analyses, plant hormone metabolism, signal transduction and cell wall loosening factors were significantly enriched due to U. esculenta infected Z. latifolia, and relative expression levels of hormone-related genes were identified, among which IAA-relative DEGs up-regulation was the most obvious in JB_B by qRT-PCR. As revealed by UHPLC analysis, the IAA, GA, Z and ZR content were increase while U. esculenta infected and ratio of these hormones to ABA also increased.

Conclusion: In this study, we come up with the hormone-cell wall loosening model to study symbiotic mechanism of gall formation after U. esculenta infected Z. latifolia. Meanwhile, our study provides a new perspective for studying the physiological and molecular mechanisms of U. esculenta infection Z. latifolia that causes swelling gall formation and theoretical basis for further increasing the future yield of Z. latifolia.
Fibular strut allograft influences reduction and outcome after locking plate fixation of comminuted proximal humeral fractures in elderly patients: a retrospective study
Authors: Cui Xueliang , chen Hui , Ma Binbin , Fan Wenbin , Li He
Published: July 2019

Purpose: The purpose of this study was to determine if fibular strut allograft influence reduction and clinical outcomes after locking plate fixation of comminuted proximal humeral fractures (PHFs).
Methods: A retrospective review was performed on sixty 3- and 4-part PHFs treated with either locking plate only or locking plate with a fibular allograft. Fracture reduction was quantitatively determined by humeral head height (HHH) and neck-shaft angle (NSA). Loss of anatomic fixation was defined if the varus malalignment of neck-shaft angle (NSA) was more than 5°or if the change of humeral head height (HHH) was more than 3 mm. Clinical outcome was evaluated by Constant-Murley score (CMS) and American Shoulder and Elbow Surgeons (ASES) score.
Result: The average radiological changes were higher in the locking compression plate (LCP) group than in the locking plate with fibular allograft (FA) group ( HHH of 4.16mm versus 1.18mm [p﹤0.001] and NSA of 9.94° versus 3.12° [p﹤0.001 ]). Final average outcome scores were lower in LCP group than in FA group ( CMS of 73.00 versus 78.96 [p = 0.024] and ASES score of 72.80 versus 78.64 [p = 0.022]). FA group showed better forward elevation (P=0.010) and abduction (P=0.002), but no significant differences were observed for shoulder external rotation or internal rotation.
Conclusion: For comminuted proximal humerus fractures in elderly patients with severe osteoporosis, locking plate fixation with a fibular strut allograft showed satisfactory radiological and clinical outcomes.
Key words: proximal humeral fractures; locking compression plate; fibular allograft
Upregulation of miR-205 induces CHN1 expression, which is associated with the aggressive behaviour of cervical cancer cells and correlated with lymph node metastasis
Authors: liu jianbing , li yunfeng , chen xihua , xu xiangbo , zhao haoqi , wang shufang , hao jianqing , he bin , liu shuyan , wang jiedong
Published: July 2019

Cervical cancer is the leading cause of cancer-related death in women worldwide. However, the mechanisms mediating the development and progression of cervical cancer are unclear. In this study, we aimed to elucidate the roles of microRNAs and CHN1 protein in cervical cancer progression. We found that miR-205 and CHN1 were highly expressed in human cervical cancer tissue compared with paired normal cervical tissues. The CHN1 gene was shown to be targeted by miR-205 in HeLa cells using software prediction and dual luciferase assays. Interestingly, transfection with miR-205 mimic upregulated CHN1 mRNA and protein, while miR-205 inhibitor downregulated CHN1 in high-risk and human papilloma virus (HPV)-negative human cervical cancer cells in vitro, as demonstrated by qRT-PCR and western blotting. These data suggested that miR-205 positively regulated the expression of CHN1. Furthermore, the miR-205 mimic promoted cell growth, apoptosis, migration, and invasion in high-risk and HPV-negative cervical cancer cells, while the miR-205 inhibitor blocked these biological processes. Knockdown of CHN1 obviously reduced the aggressive cellular behaviours induced by upregulation of miR-205, suggesting that miR-205 positively regulated CHN1 to mediate these cell behaviours during the development of cervical cancer. Furthermore, CHN1 was correlated with lymph node metastasis in clinical specimens, as shown by immunohistochemistry. Taken together, our findings showed that miR-205 positively regulated CHN1 to mediate cell growth, apoptosis, migration, and invasion during cervix cancer development, particularly for high-risk HPV-type cervical cancer. These findings suggested that dysregulation of miR-205 and subsequent abnormalities in CHN1 expression promoted the oncogenic potential of human cervical cancer.
Five Serum Trace Elements Associated with Risk of Cardia and Non-cardia Gastric Cancer in a Matched Case-control Study
Authors: Lin Yulan , Wu Chuancheng , Yan Wei , Guo Saixiong , Liu Baoying
Published: July 2019

Background: Serum trace elements have been some time suggested to influence the development of gastric cancer, but evidence is still lacking.

Methods: In a case-control study from a high risk region of East China, all newly diagnosed patients with gastric cancer were compared with healthy controls 1:1 matched by sex, age (± 3 years) and place of residence during 2013- 2015.

Results: A total of 299cases of gastric cancers, which included 122 cases of gastric cardia cancer (GCC) and 177 gastric non-cardia cancer (NCGC), and 299 healthy controls were included. Positive associations were found between serum copper and copper/zinc ratio and risk of overall gastric cancer (OR4th vs. 1st quartile: 2.42, 95% CI: 1.10-5.32 for copper, p for trend=0.003; OR4th vs. 1st quartile: 11.7, 95% CI: 3.83-35.6 for copper/zinc ratio, p for trend<0.0001), and for both GCC and NCGC subtypes. Serum selenium inversely associated with risk of NCGC (OR4th vs. 1st quartile: 0.18, 95% CI: 0.07-0.51, p for trend=0.0001), while molybdenum seem to reduce risk of GCC (OR4th vs. 1st quartile: 0.12, 95% CI: 0.03-0.47, p for trend<0.0001). Strong inverse associations were also detected between serum calcium and risk of all groups of gastric cancer (all p for trend<0.05). Although intermediate serum level of zinc and iron had lower risk of gastric cancer, no linear association was however found (all p for trend>0.05).

Conclusions: The current study present evidences for positive associations between copper, copper/zinc ratio and gastric cancer, as well as for inverse associations between serum selenium, molybdenum and calcium and risk of gastric cancer.
Childhood maltreatment as a risk factor for cancer: Findings from a population-based survey of Canadian adults
Authors: Hovdestad Wendy , Shields Margot , Shaw Amanda , Tonmyr Lil
Published: July 2019

Background

Childhood maltreatment (CM) is an established risk factor for various mental and substance use disorders. This study adds to existing evidence that CM may also be a risk factor for cancer.

Methods

Based on data from a sample of 9,783 men and 12,132 women from the 2012 Canadian Community Health Survey - Mental Health (CCHS - MH), this analysis explores mediated associations between cancer in adulthood and different levels of exposure to three types of CM—childhood physical abuse (CPA), childhood sexual abuse (CSA), and childhood exposure to intimate partner violence (CEIPV). “Cancer” was defined as an affirmative response to either of these questions: ‘‘Do you have cancer?’’ or ‘‘Have you ever been diagnosed with cancer?’’ The potential mediators were: smoking, depression, alcohol abuse/dependence, life stress, obesity, and physical activity.

Results

For women, but not men, having experienced CM was significantly associated with a cancer diagnosis in adulthood, even when effects due to age and socio-demographic characteristics were controlled. Smoking, life stress, depression, and alcohol abuse/dependence reduced the strength of the association between CM and cancer in women. However, most associations remained statistically significant when controlling for effects due to these behavioural and other mediators. Evidence indicated a “dose-response” relationship, in that the likelihood of reporting cancer increased with the number of abuse types (CPA, CSA, CEIPV) reported, and with the severity of CPA.

Conclusions

The analyses suggest an association between CM and cancer in women, even when the effects of known risk factors were taken into account. The association was graded, becoming stronger as CM exposure increased. Implications for the provision of cancer screening and other health care services to women with histories of CM to reduce health disparities are discussed.
Implementation of an anaesthesia quality improvement programme to reduce fibreoptic bronchoscope repair incidents
Authors: Lu Hsiao-Feng , Hung Kuo-Chuan , Chiang Min-Hsien , Yang Johnson Chia-Shen , Luo Sheng-Dean , Chin Jo-Chi , Wang Chih-Hsien , Sun Cheuk-Kwan , Wu Shao-Chun
Published: July 2019

BACKGROUND

This study aimed at investigating the effectiveness of the implementation of a comprehensive quality improvement programme (QIP) for reducing the repair rate of fibreoptic bronchoscope (FOB).

METHODS

A three-stage improvement strategy was implemented between January 2013 and 2016 December. Stage One: Acquisition of information on violations of practice guidelines, repair rate, cost of repair and incidence of unavailability of FOB during anaesthesia induction of the previous year through auditing. Stage Two: Implementation of a quality improvement campaign (QIC) based on results of Stage One. Stage Three: Programme perpetuation through monitoring compliance with policy on FOB use by regular internal audits. The effectiveness was retrospectively analyzed on a yearly basis.

RESULTS

The annual repair rate, repair cost, and incidence of FOB unavailability before the QIP implementation were 1%, USD18,757, and 1.4% respectively. After QIC, the repair rate in 2013 dropped by 81% (from 1% in 2012 to 0.19% in 2013, p<0.05). The annual repair cost fell by 32% from USD18,758 (2012) to USD12,820 (2013). Besides, the incidence of FOB unavailability plummeted by 71% from 1.4% to 0.4% during the same period. The annual repair rates and incidence of FOB unavailability remained lower in subsequent three years than those before QIP implementation.

CONCLUSIONS

Implementation of a quality improvement programme was effective for reducing the rate and cost of FOB repair as well as unavailability rate, highlighting its beneficial impact on cost-effectiveness and patient safety in a tertiary referral center setting.
Efficacy of air purifier therapy for patients with allergic asthma
Authors: LUO Jiaying , Chen Zhao , Ou Li-li , Lin Xin-yuan , Liu Hai-cheng , Fan Li-min , Sun Bao-qing
Published: July 2019

Background and Objectives: The prevalence of allergic disease, which has a severely negative effect on patients' quality of life, has been increasing in recent years. Environmental intervention is internationally regarded as a feasible method for controlling asthma. Thus, this study aimed to evaluate the efficacy of air purifier therapy for patients with allergic asthma.
Methods: In total, 38 subjects were divided into a treatment group and a control group. All subjects were under the age of eighteen years and had been clinically diagnosed with allergic asthma. The treatment group used High Efficiency Particulate Air (HEPA) air purifiers for six consecutive months, and the control group did not use the air filters. Particulate matter (PM) data and dust samples (bedding and a static point) were collected from the subjects' bedrooms before they started to use the air purifiers and each month thereafter. Simultaneously, the subjects were asked to complete a questionnaire for the Asthma Control Test (ACT) or Childhood Asthma Control Test (C-ACT). Fractional exhaled nitric oxide (FENO) tests were performed at the start and end of the study. The concentrations of Der p1 and Der f1 were measured in the dust samples.
Results: 1. After utilizing an air purifier, the concentrations of house dust mite (HDM) allergens (Der p1+ Der f1) in the bedding and static samples decreased by 68.3% and 71.0%, respectively. In addition, the PMindoor/outdoor levels significantly decreased. 2. The ACT and C-ACT scores in the treatment group maintained a steady significant upward trend. 3. At the end of the study, the FENO levels in both groups were lower, although the differences were not significant.
Conclusions: HEPA air purifiers are able to decrease indoor HDM allergen and PM levels and improve quality of life in allergic asthma patients.
The effects of age, cigarette smoking, sex and race on the qualitative characteristics of lung transcriptome
Authors: Guan Qingzhou , Zhang Juan , Guo You , Xia Jie , Zhang Jiahui , Xie Jiajing , Cai Hao , Yan Haidan , Wang Xianlong , Guo Zheng
Published: July 2019

Background

Methods based on within-sample relative expression orderings (REOs) comparisons could be applied for various medical issues such as individualized diagnosis of cancer and subtype identification etc., it could also be used for identifying differentially expressed genes (DEGs) at the individual level and detecting disease-associated genes based on one-phenotype disease data by reusing data of normal samples from other sources. However, the common potential confounding factors, including age, cigarette smoking, sex and race whether could affect the REOs of gene pairs is still unclear. Here, we evaluated these confounding factors on the REOs of gene pairs within normal lung tissues transcriptome.

Results

For one confounding factor, based on the number of related gene pairs or DEGs, the effect of this confounding factor on REO was evaluated. Our results showed that age has little effect on REOs within lung tissues. We found that about 0.23% of the significantly stable REOs of gene pairs in non-smokers’ lung tissues are reversed in smokers’ lung tissues, introduced by 344 DEGs between the two groups of samples (RankCompV2, FDR < 0.05), which are enriched in metabolism of xenobiotics by cytochrome P450, glutathione metabolism and other pathways (hypergeometric test, FDR < 0.05). Comparison between the normal lung tissue samples of males and females revealed fewer reversal REOs introduced by 24 DEGs between the sex groups, among which 19 DEGs are located on sex chromosomes and 5 DEGs involving in spermatogenesis and regulation of oocyte are located on autosomes. Between the normal lung tissue samples of white and black people, we identified 22 DEGs (RankCompV2, FDR < 0.05) which introduced a few reversal REOs between the two races.

Conclusions

In summary, the REO-based study should consider the confounding factors of cigarette smoking, sex and race.
Factors Associated with Gastrointestinal Bleeding During Hospitalization for Transcatheter Aortic Valve Replacement: A Retrospective Cohort Study
Authors: Spiewak Ted Andrew , Eskandari Armen , Wang Tim W. , Bang Heejung , Stripe Benjamin R. , Choi Jeong W. , Wong Garrett B. , Southard Jeffrey A. , Boyd Walter D. , Tejaswi Sooraj
Published: July 2019

Background & Aims

Gastrointestinal bleeding (GIB) is the most common bleeding complication post transcatheter aortic valve replacement (TAVR). Yet, the literature is sparse and incomplete. This study aims to identify the incidence and risk factors for GIB immediately following TAVR.

Methods

A retrospective study was performed among 489 patients who were hospitalized for TAVR at UC Davis Medical Center from (January 1, 2012 to June 30, 2017). The incidence of both upper and lower GIB, and potential risk factors during the same hospitalization were reviewed. Univariate analysis was done to identify independent risk factors.

Results

Mean age was 81.6 years and 49% were male, 23% had CKD3 or worse, 34% had history of prior GIB. Mean baseline Hgb and platelet count were 12.0 g/dl and 197000/ml, respectively. Dual antiplatelet therapy and anticoagulation were used in 396 (81%) and 155 (32%) patients, respectively. Gastric prophylaxis with either PPIs or H2 receptor blockers was used in 336 (69%). Incidence of GIB was 1.4% (7/489) with 5 cases of upper GIB, 1 small intestinal GIB and 1 lower GIB. The most common culprit lesion found during endoscopy was angiodysplasia (3/5) and successful endoscopic intervention was performed. On univariate regression analysis, only a low hemoglobin level on admission was associated with increased likelihood of GIB (OR=1.49, p=0.051 per 1 g/dl decrease).

Conclusions

GIB is rare immediately post-TAVR. Angiodysplasia was the most common etiology in our series. Baseline anemia is a predictor of GIB in this setting.
Evaluating the rate of contamination of raw milk with pathogenic biotypes of Yersinia enterocolitica in the North-East of Iran
Authors: Movafagh Fahimeh , Zeinali Tayebeh , Jamshidi Abdollah
Published: July 2019

Objective: This study aimed to evaluate the contamination rate of raw milk to Y. enterocolitica and biotyping of isolated organisms.
Results: The results showed 33% of raw milk samples were contaminated with Yersinia enterocolitica. 1A biotype was the predominant one (26%) but two pathogenic biotypes including 1B (6%) and 5 (1%) were also detected. Isolation of potentially pathogenic Y. enterocolitica from raw milk and consequently its presence in dairy products which are made from raw milk is a public health hazard.
Effect of Community Led Total Sanitation and Hygiene (CLTSH) Implementation program on Latrine Utilization among Adult Villagers of North Ethiopia. A Cross-sectional Study
Authors: Gebremariam Brhane , Tsehaye Kenfe
Published: July 2019

Objective

Absence of latrine remains a common public health problem in most of the Sub-Saharan Africa countries. A cross-sectional study was conducted to assess the effect of community-led total sanitation and hygiene approach implementation and associated factors among villages of Laelai Maichew District, Tigray, and North Ethiopia.

Results

This study revealed that the rate of latrine use in the rural community of Laelai-Maichew district was about 46.8%. The majority, 71.1% of households in CLTSH implemented Villages and 93.5%of households in CLTSH non-implemented Villages did not have hand washing facility around their latrine. Community-led to total sanitation and hygiene non-implemented villages were 49% times less likely to utilize their latrine compared to those community-led total sanitation implemented villages [AOR=0.51 95% CI (0.35, 0.75)]. Households owned latrines for two and above years were 1.5 more likely to utilize their latrine [AOR=1.50 95% CI (1.21, 2.59)] than those of owning latrines for less than two years. In this study, latrine use rate was low. As a result, the local, national governmental and non-governmental organization should design programs to create behavioral changes on the community’s attitude towards latrine utilization.
A web of 2d dualities: ${\bf Z}_2$ gauge fields and Arf invariants
Authors: Karch Andreas , Tong David , Turner Carl
Published: July 2019

We describe a web of well-known dualities connecting quantum field
theories in d=1+1 dimensions. The web is constructed by gauging
Z_2Z2
global symmetries and includes a number of perennial favourites such as
the Jordan-Wigner transformation, Kramers-Wannier duality, bosonization
of a Dirac fermion, and T-duality. There are also less-loved examples,
such as non-modular invariant c=1 CFTs that depend on a background spin
structure.
Data transformation models utilized in Bayesian probabilistic forecast considering inflow forecasts
Authors: Xu Wei , Fu Xiaoying , Li Xia , Wang Ming
Published: July 2019

This paper presents a new Bayesian probabilistic forecast (BPF) model to improve the efficiency and reliability of normal distribution transformation and to describe the uncertainties of medium-range forecasting inflows with 10 days forecast horizons. In this model, the inflow data will be transformed twice to a standard normal distribution. The Box–Cox (BC) model is first used to quickly transform the inflow data with a normal distribution, and then, the transformed data are converted to a standard normal distribution by the meta-Gaussian (MG) model. Based on the transformed inflows in the standard normal distribution, the prior and likelihood density functions of the BPF are established, respectively. In this study, the newly developed model is tested on China's Huanren hydropower reservoir and is compared with BPFs using MG and BC, separately. Comparative results show that the new BPF model exhibits significantly improved data transformation efficiency and forecast accuracy.
Integrated hydrological modelling of surface water and groundwater under climate change: the case of the Mygdonia basin in Greece
Authors: Malamataris Dimitrios , Kolokytha Elpida , Loukas Athanasios
Published: July 2019

Lakes Volvi and Koronia are located in the Mygdonia basin and constitute the second and fifth largest natural lakes in Greece, respectively. The lakes along with the Mygdonia basin aquifer have undergone severe quantitative and qualitative degradation, while Lake Koronia has been totally depleted in recent years. In this study, a fully integrated hydrological analysis of the Mygdonia basin for historical and future periods is carried out. Future climatic data were derived and analyzed from a Regional Climate Model, while the implications of climate change on the water balance of both lakes and the Mygdonia basin aquifer until 2100 were projected by developing a modelling system which includes coupled hydrological and hydraulic models, such as UTHBAL, MIKE SHE, MIKE HYDRO River and the MIKE HYDRO Basin. The results indicated that the precipitation is expected to decrease by 17%, the temperature to increase by 2.90 °C and as a result, the surface runoff is projected to decrease by 21% and the groundwater recharge to decrease by 38% in the Mygdonia basin at the end of the century. The above changes would have a direct negative impact on the Lakes Koronia and Volvi and the Mygdonia basin aquifer future water balance necessitating adaptation measures.
ICT-competence of university lecturers: diagnostics and development
Authors: Chuvgunova O. A.
Published: July 2019

The purpose of the study. This article is devoted to reveal the directions of development of lecturers’ information and communication technology (ICT) competences. The level of lecturers’ ICT-competence, feedback from students about efficiency of ICT using at the University, structure of lecturers’ ICT-competence and communicative competence correlation, lecturers’ demands in ICT-competence training were investigated.

Methods. Lecturers’ survey (questionnaire “ICT-using by University lecturers” by O. Chuvgunova), students’ survey (questionnaire “ICT at University: students’ feedback” by O. Chuvgunova), psychological test (“Communicative skills test” by L. Michelson), math statistics methods. Sample was formed from lecturers (N = 102) and students (N = 198) of St. Petersburg University.

Results. Results show that lecturers have high marks of base level and technological level of ICT competence. Lecturers have ICT literacy and can use ICT as a tool for communication with students. But professional level of the most part of participants’ ICT competence is not developed well enough. Hence, some lecturers cannot create and implement new instruments, methods into educational process through ICT.

The feedback from undergraduates demonstrates that students appreciate highly using ICT at their faculties. Respondents think that ICT improves the effectiveness of learning process. At the same time, it is important for students to take into account their individual characteristics and the optimal balance between virtual and “live” communication.

Study revealed positive correlation between indicators of ICT competence and communicative competence. Lecturers with high communicative competence have high level of ICT competence and high self-rating of their own ICT competence.

Lecturers are interested in ICT-competence training. Mostly, they use different courses and self-education. Most lecturers do not have a plan of their ICT-competence development.

Conclusion. The study found out such directions of lecturers’ ICT-competence development, as:

– using ICT as a resource of improvement of educational process, development of students’ intelligence and creativity;

– lecturers should take into account students’ individual features and students’ feedback through ICT using;

– enhancement of lecturers’ communicative competence as a necessary skill of interactive ICT using;

– efficiency increase of lecturers’ ICT competence training through permanent educational environment and consulting by ICT specialists.
Novel Insight into Differential Gene Expression and Clinical Significance of Dopamine Receptors, COMT, and IL6 in BPH and Prostate Cancer
Authors: Akbarian Fatemeh , Abolhasani Maryam , Dadkhah Farid , Asadi Farrokh , Ahangari Ghasem
Published: July 2019

Background:

Benign prostatic hyperplasia (BPH) and prostate cancer (PCa)
are the most prevalent diseases in male population, implicated with fundamental
differences between benign and malignant growth of prostate cells. An imbalance
through a network of nervous, endocrine, and immune systems initiate a signal of
altered growth from the brain to the prostate gland, leading to adverse effects such as
inflammation.

Objective:

The aim of this study was to evaluate the gene expression of dopamine
receptor family, COMT, and IL6 to identify novel correlations in BPH and PCa in both
blood and tumor of the patients.

Method:

Peripheral blood mononuclear cells from BPH (n= 30) and PCa (n= 30)
patients, and prostate tumor tissues (n= 14) along with pathologically normal adjacent
tissues (n= 14) were isolated, mRNA was extracted, and cDNA was synthesized,
respectively. Quantitative real- time PCR was applied for DRD1- DRD5, COMT, and IL6
genes in all samples.

Results:

We found, for the first time, that the expression of COMT and IL6 genes were
inversely correlated with the expression of DRD1 and DRD2 genes through the extent of
differentiation of PCa from BPH condition. In addition, the PSA levels were correlated
with the expression of DRD1 in BPH cases and DRD1, DRD4, DRD5, and IL6 in PCa
cases.

Conclusion:

Results implicate a potential cross- talk between the signaling pathways
derived by IL6 cytokine and dopamine receptors in PCa. Thus, it seems promising to reassemble
the consequent signaling pathways by adequate agonists and antagonists to
help increase therapeutic efficacy.
Contemporary Pharmacologic Management of Heart Failure with Reduced Ejection Fraction: A Review
Authors: Egbuche Obiora , Hanna Bishoy , Onuorah Ifeoma , Uko Emmanuela , Taha Yasir , Ghali Jalal K. , Onwuanyi Anekwe
Published: July 2019

Heart failure with reduced ejection fraction (HFrEF) is defined as the presence of typical
symptoms of heart failure (HF) and a left ventricular ejection fraction ≤ 40%. HFrEF patients constitute
approximately 50% of all patients with clinical HF. Despite breakthrough discoveries and
advances in the pharmacologic management of HF, HFrEF patients continue to pose a significant
economic burden due to a progressive disease characterized by recurrent hospitalizations and need
for advanced therapy. Although there are effective, guideline-directed medical therapies for patients
with HFrEF, a significant proportion of these patients are either not on appropriate medications’
combination or on optimal tolerable medications’ doses. Since the morbidity and mortality benefits
of some of the pharmacologic therapies are dose-dependent, optimal medical therapy is required to
impact the burden of disease, quality of life, prognosis, and to curb health care expenditure. In this
review, we summarize landmark trials that have impacted the management of HF and we review
contemporary pharmacologic management of patients with HFrEF. We also provide insight on general
considerations in the management of HFrEF in specific populations. We searched PubMed,
Scopus, Medline and Cochrane library for relevant articles published until April 2019 using the following
key words “heart failure”, “management”, “treatment”, “device therapy”, “reduced ejection
fraction”, “guidelines”, “guideline directed medical therapy”, “trials” either by itself or in combination.
We also utilized the cardiology trials portal to identify trials related to heart failure. We reviewed
guidelines, full articles, review articles and clinical trials and focused on the pharmacologic
management of HFrEF.
A Comparative Chemometric Study for Quantitative Determination of Duloxetine Hydrochloride in the Presence of its Toxic Impurity 1-Naphthol
Authors: Anwar Basma H. , Abdelhamid Nessreen S. , Magdy Maimana A. , Naguib Ibrahim A.
Published: July 2019

Background:

Duloxetine hydrochloride (DUL) is a serotonin-norepinephrine reuptake inhibitor. It is used for treating depression and anxiety. It is available in the market as a capsule called Cymbatex®, which is used for the treatment of depression. 1-naphthol is a potential impurity of DUL. It is hepatotoxic to humans and has potential toxicity to freshwater fish.

Objective:

Duloxetine hydrochloride was determined in the presence of its toxic impurity 1-naphthol in raw material and in pharmaceutical dosage forms using three multivariate calibration chemometric methods.

Methods:

Classical Least Squares (CLS), Partial Least-Squares (PLS) and linear support vector regression (SVR) were developed using UV spectral data. The three methods were compared among each other and the advantages and disadvantages were discussed. For good results, a two-factor four-level experimental design was used, resulting in a training set of 16 mixtures containing different ratios of each component. The test set consisting of nine mixtures was necessary to test the ability of the proposed methods to predict DUL in the presence of its impurity, 1-naphthol.

Results:

The results show the success of the three developed methods to determine DUL in the presence of small levels of its toxic impurity with good accuracy and selectivity. The results of the dosage form were compared statistically to that of the reported HPLC method, with no significant difference in accuracy and precision.

Conclusion:

The suggested calibration models are suitable for routine analysis of the drug in bulk and pharmaceutical dosage forms. Compared to the CLS and PLS models, the SVR model gives the best results regarding the accuracy with a lower prediction error and better generalization ability. However, the CLS and PLS models are found to be simpler and faster in usage and management.
Remote Management of Poststroke Patients With a Smartphone-Based Management System Integrated in Clinical Care: Prospective, Nonrandomized, Interventional Study (Preprint)
Authors: Kim Do Yeon , Kwon Hee , Nam Ki-Woong , Lee Yongseok , Kwon Hyung-Min , Chung Young Seob
Published: July 2019

BACKGROUND

Advances in mobile health (mHealth) have enabled systematic and continuous management of patients with chronic diseases.

OBJECTIVE

We developed a smartphone-based mHealth system and aimed to evaluate its effects on health behavior management and risk factor control in stroke patients.

METHODS

With a multifaceted stroke aftercare management system that included exercise, medication, and educational materials, we performed a 12-week single-arm intervention among eligible poststroke patients in the stroke clinic from September to December 2016. The intervention consisted of (1) regular blood pressure (BP), blood glucose, and physical activity measurements; (2) stroke education; (3) an exercise program; (4) a medication program; and (5) feedback on reviewing of records by clinicians. Clinical assessments consisted of the stroke awareness score, Beck Depression Inventory-II (BDI), EuroQol-5 Dimensions (EQ-5D), and BP at visit 1 (baseline), visit 2 (4 weeks), and visit 3 (12 weeks). Temporal differences in the parameters over 12 weeks were investigated with repeated-measures analysis of variance. Changes in medication adherence at visit 1-2 (from visit 1 to visit 2) and visit 2-3 (from visit 2 to visit 3) were compared. System satisfaction was evaluated with a self-questionnaire using a 5-point Likert scale at visit 3.

RESULTS

The study was approved by the Institutional Review Board in September 2016, and participants were enrolled from September to December 2016. Among the 110 patients enrolled for the study, 99 were included in our analyses. The mean stroke awareness score (baseline: 59.6 [SD 18.1]; 4 weeks: 67.6 [SD 16.0], P<.001; 12 weeks: 74.7 [SD 14.0], P<.001) and BDI score (baseline: 12.7 [SD 10.1]; 4 weeks: 11.2 [SD 10.2], P=.01; 12 weeks: 10.7 [SD 10.2], P<.001) showed gradual improvement; however, no significant differences were found in the mean EQ-5D score (baseline: 0.66 [SD 0.33]; 4 weeks: 0.69 [SD 0.34], P=.01; 12 weeks: 0.69 [SD 0.34], P<.001). Twenty-six patients who had uncontrolled BP at baseline had −13.92 mmHg (P=.001) and −6.19 mmHg (P<.001) reductions on average in systolic and diastolic BP, respectively, without any antihypertensive medication change. Medication compliance was better at visit 2-3 (60.9% [SD 37.2%]) than at visit 1-2 (47.8% [SD 38.7%], P<.001).

CONCLUSIONS

Awareness of stroke, depression, and BP was enhanced when using the smartphone-based mHealth system. Emerging mHealth techniques have potential as new nonpharmacological secondary prevention methods because of their ubiquitous access, near real-time responsiveness, and comparatively lower cost.
How Contextual Constraints Shape Midcareer High School Teachers' Stress Management and Use of Digital Support Tools: Qualitative Study (Preprint)
Authors: Manning Julia B , Blandford Ann , Edbrooke-Childs Julian , Marshall Paul
Published: July 2019

BACKGROUND

Persistent psychosocial stress is endemic in the modern workplace, including among midcareer high school (secondary comprehensive) teachers in England. Understanding contextual influences on teachers' self-management of stress along with their use of digital health technologies could provide important insights into creating more usable and accessible stress support interventions.

OBJECTIVE

The aim of this study was to investigate the constraints on stress management and prevention among teachers in the school environment and how this shapes the use of digitally enabled stress management tools.

METHODS

Semistructured interviews were conducted with 14 teachers from southern England. The interviews were analyzed using thematic analysis.

RESULTS

Teachers were unanimous in their recognition of workplace stress, describing physical (such as isolation and scheduling) and cultural (such as stigma and individualism) aspects in the workplace context, which influence their ability to manage stress. A total of 12 participants engaged with technology to self-manage their physical or psychological well-being, with more than half of the participants using consumer wearables, but Web-based or smartphone apps were rarely accessed in school. However, digital well-being interventions recommended by school leaders could potentially be trusted and adopted.

CONCLUSIONS

The findings from this study bring together both the important cultural and physical contextual constraints on the ability of midcareer high school teachers to manage workplace stress. This study highlights correlates of stress and offers initial insight into how digital health interventions are currently being used to help with stress, both within and outside high schools. The findings add another step toward designing tailored digital stress support for teachers.
Engaging parent–child dyad and healthcare provider stakeholders in a patient-centered comparative effectiveness study
Authors: Woods-Jaeger Briana A , Sexton Chris C , Branch Cassidy , Bolenbaugh Mallory , Roth Lisa , Stelson Elisabeth A , Braaten Nikki , Ramirez Marizen
Published: July 2019

Aim:
Describe engagement activities in a comparative effectiveness study evaluating two interventions for promoting psychosocial health among youth ages 10–17 who have recently experienced a nonintentional injury.
Methods:
Institutional, community and patient stakeholders from four children’s hospitals were engaged through consultation meetings, individual interviews and a collaborative meeting.
Results:
67 engagement activities were conducted across four hospitals. Feedback to improve recruitment, retention and continuous engagement in the study was obtained. Finally, disseminating study interventions to school and healthcare settings, and adding alternative delivery formats were identified as priority next steps.
Conclusion:
Results highlight diverse methods of engaging patient and professional stakeholders, critical recommendations for improving study engagement and retention, and future directions for this patient-engaged comparative effectiveness research.
OPTIMASI PEMUPUKAN PADI GOGO SEBAGAI TANAMAN SELA TANAMAN KARET BELUM MENGHASILKAN
Authors: Sahuri Sahuri , Nugraha Iman Satra , Nurmansyah Nurmansyah
Published: July 2019

Penanaman padi gogo di gawangan karet sebagai alternatif untuk meningkatkan produktivitas lahan dan pendapatan petani. Penelitian ini bertujuan mendapatkan paket pemupukan NPK padi gogo sebagai tanaman sela karet dan mengetahui pengaruh tumpangsari padi gogo terhadap pertumbuhan karet klon PB 340. Penelitian dilaksanakan di Kebun Percobaan Balai Penelitian Sembawa dari bulan November 2016 sampai Maret 2017. Penelitian menggunakan rancangan petak terpisah, 3 ulangan. Petak utama adalah kombinasi pupuk P dan K, 4 perlakuan: 1) 0 kg P205/ha + 0 kg K20/ha, 2) 36 kg P205/ha + 0 kg K20/ha, 3) 0 kg P205/ha + 60 kg K20/ha, dan 4) 36 kg P205/ha + 60 kg K20/ha. Anak petak adalah pemberian pupuk N dengan 4 perlakuan: 1) 0, 45, 90, dan 135 kg N/ha. Hasil penelitian menunjukkan bahwa tumpangsari padi gogo berpengaruh terhadap peningkatan produktivitas lahan dan pertumbuhan karet. Kombinasi pupuk NPK yang optimal untuk meningkatkan pertumbuhan dan hasil padi gogo sebagai tanaman sela karet adalah (90 kg N/ha + 36 kg P205/ha + 60 kg K20/ha).
PENILAIAN HASIL BELAJAR SISWA DALAM PEMBELAJARAN KIMIA MATERI KIMIA UNSUR MENGGUNAKAN MIND MAP DI KELAS XII IPA SEMESTER 1 SMA NEGERI 1 WONOSARI
Authors: Purba Asmara Anjar
Published: July 2019

This research is aimed to determine the quality of mind maps which have created by students and to determine the result of students learning in chemistry lesson by using mind map model. The research uses description qualitative method. The population is students of natural science program grade XII at SMA 1 Wonosari years 2013/2014. The sample consists of 96 students at class XII IPA1, XII IPA2, and XII IPA3. The research gives imformation about the quality of studentâ€™s mind map which have scored by using mind map scoring rubric and the result of students learning which have tested by giving daily examination. The percentage of very good category, good category, and good enough category is 40%, 40%, and 20% respectively. The average of test value is 80.406, it means that the average value is higher than minimal passing standart. The percentage of student which pass the test is 80.208%. thus the result to be categorized as good level.
PENCAPAIAN HASIL BELAJAR MATA PELAJARAN ILMU PENGATAHUAN SOSIAL MELALUI MINAT BELAJAR SISWA
Authors: Muhammad Maryam
Published: July 2019

Learning is a process of a person in gaining skills, learning skills and attitudes so that it does not come just like that, but it must be carried out deliberately in a certain time anyway. While the study results are around the skills and the results achieved through the learning process in universities and designated with the numbers measured by tests of learning outcomes. In regard to interest a person against an object reflected in the behavior. In the case of interest is motivated by a person's attention to a particular object of interest, such as attention, curiosity is high, and the need for decisive for the selection of the object of his favorite things. Interest that is an element in achieving success for someone. If someone is interested in social studies, all the attention, curiosity, and the need to subject Soasial Sciences, will be higher, so the higher the learning outcomes of subjects who achieved Sciences, Soasial entered. Turns impacted student interest in learning and have a positive influence on the achievement of learning outcomes Sciences, Soasial subjects. The higher the interest of students in learning subjects of Sciences, Soasial, the higher the learning outcomes of subjects Sciences, Soasial achieved. Conversely the lower the student's interest in learning subjects of Sciences, Soasial, then the lower the learning outcomes of subjects who achieved Sciences, Social.
OPTIMALISASI PENGGUNAAN ABSHAR DALAM BELAJAR DAN PEMBELAJARAN
Authors: Hilmi Hilmi
Published: July 2019

Using Abshar (visual) as one of the resources in learning has increased from one period to the next period. The more optimal in using abshar, the more successful in learning activities will be. The discovery of various theories in various branches of science shows the result of reading kauniyah from scholars. Furthermore, nowadays is the time of the sophisticated and modern where abshar has greater role in learning. People who do not use abshar optimally will fall behind and backwardness, because various means of science and technology can only be used by optimizing the use of abshar. Basically, long time ago the Al- Qur'an as a guide for all human beings has talked about optimizing the use of this abshar both in learning and teaching activities. This paper by using the approach of the Thematic Study (Maudhu'i) will try to review the use of optimization abshar in learning activities and teaching learning process from the perspective of the Al-Qurâ€™an.
IMPLEMENTASI PEMBELAJARAN KIMIA BERBASIS LINGKUNGAN DENGAN MODEL PROBLEM BASED LEARNING (PBL) UNTUK MENINGKATKATKAN MINAT DAN KETERAMPILAN BERPIKIR KRITIS PADA SISWA SMA
Authors: Husni Husni
Published: July 2019

This study aims to analyze: (1) the difference between the critical thinking skills that students learn through the implementation model of Problem Based Learning (PBL) environment based on petroleum materials with students who learn through conventional learning model (2) differences in student interest through implementation model (PBL) environment based on the students' interest through conventional learning models. This study was a quasi-experimental research in class X of SMA KARTIKA XIV-1 BANDA ACEH in Academic Year 2013/2014. The research design was a two-group pretest-posttest design. Data were analyzed by independent t-test statistical analysis test with the software program SPSS version 17. The results obtained by analysis of the percentage of the average value of the initial test experimental class is 25.00 and 24.69 for the control class. Furthermore, the percentage of the average value of the final test in the experimental class at 77.35, while the control class is 62.19. The average N-gain normalized experimental class were high with an average rating of 0.75 while the control class including medium category with an average rating of 0.50. For N-normalized gain obtained t = 6.045 with signfikansi p = 0.000, due to the significance