bluuebunny/crossref_metadata_2025 huggingface dataset:
Thumb Duplication Surgical Treatment: Outcomes and Results
Authors: Monjardino Maria Pia , Carvalho Marcos , Cardoso Pedro Sá , Ling Tah Pu , Alves Cristina
Published: January 2023

Aim

This study aims to evaluate functional and esthetic outcomes of thumb duplication correction in pediatric age.

Methods

Retrospective study including all pediatric patients with thumb duplication undergoing surgical treatment between 2012 and 2017. We analyzed demographic data, surgical technique, and surgical outcomes considering Tada, Horii, and Tien scores, according to the following parameters: active mobility of the metacarpophalangeal and interphalangeal joints, stability, alignment, and family’s opinion about cosmetic and function of the thumb. The Wassel-Flatt classification was used to classify the duplicated thumbs.

Results

A total of 11 patients were included, predominantly male (ratio 1.8:1), with a median age at time of surgery of 19[10-26] months and a median follow-up time after surgery of 23 [3-63] months. The Wassel- Flatt type IV thumb was the most frequent (73%). The postoperative evaluation revealed that 82% of patients had good results in Tada score, 73% had good results in Horii score, and all patients showed good results in Tien score. We found a relation between lower age and fair postoperative alignment ( P = .047) and between fair postoperative alignment and fair final Tada ( P = .022), Horii ( P = .006), and Tien ( P = .009) scores.

Conclusions

Excision and reconstruction procedures are good options in the treatment of thumb duplication providing good clinical results, with excellent parent satisfaction. Timing of surgery is important for favorable esthetic outcomes, while angular deformity is a determining factor that for postoperative dissatisfaction.
Modeling the Natural History and Screening Effects of Colorectal Cancer Using Both Adenoma and Serrated Neoplasia Pathways: The Development, Calibration, and Validation of a Discrete Event Simulation Model
Authors: Cheng Chih-Yuan , Calderazzo Silvia , Schramm Christoph , Schlander Michael
Published: January 2023

Background. Existing colorectal cancer (CRC) screening models mostly focus on the adenoma pathway of CRC development, overlooking the serrated neoplasia pathway, which might result in overly optimistic screening predictions. In addition, Bayesian inference methods have not been widely used for model calibration. We aimed to develop a CRC screening model accounting for both pathways, calibrate it with approximate Bayesian computation (ABC) methods, and validate it with large CRC screening trials. Methods. A discrete event simulation (DES) of the CRC natural history (DECAS) was constructed using the adenoma and serrated pathways in R software. The model simulates CRC-related events in a specific birth cohort through various natural history states. Calibration took advantage of 74 prevalence data points from the German screening colonoscopy program of 5.2 million average-risk participants using an ABC method. CRC incidence outputs from DECAS were validated with the German national cancer registry data; screening effects were validated using 17-y data from the UK Flexible Sigmoidoscopy Screening sigmoidoscopy trial and a German screening colonoscopy cohort study. Results. The Bayesian calibration rendered 1,000 sets of posterior parameter samples. With the calibrated parameters, the observed age- and sex-specific CRC prevalences from the German registries were within the 95% DECAS-predicted intervals. Regarding screening effects, DECAS predicted a 41% (95% intervals 30%–51%) and 62% (95% intervals 55%–68%) reduction in 17-y cumulative CRC mortality for a single screening sigmoidoscopy and colonoscopy, respectively, falling within 95% confidence intervals reported in the 2 clinical studies used for validation. Conclusions. We presented DECAS, the first Bayesian-calibrated DES model for CRC natural history and screening, accounting for 2 CRC tumorigenesis pathways. The validated model can serve as a valid tool to evaluate the (cost-)effectiveness of CRC screening strategies.

Highlights

This article presents a new discrete event simulation model, DECAS, which models both adenoma-carcinoma and serrated neoplasia pathways for colorectal cancer (CRC) development and CRC screening effects. DECAS is calibrated based on a Bayesian inference method using the data from German screening colonoscopy program, which consists of more than 5 million first-time average-risk participants aged 55 years and older in 2003 to 2014. DECAS is flexible for evaluating various CRC screening strategies and can differentiate screening effects in different parts of the colon. DECAS is validated with large screening sigmoidoscopy and colonoscopy clinical study data and can be further used to evaluate the (cost-)effectiveness of German colorectal cancer screening strategies.
Matrix Tailoring for Polyvinyl Alcohol (PVA) Fiber-Reinforced Ductile Cementitious Composites
Authors: Arain Muhammad Fahad , Memon Hafeezullah , Wang Mingxue , Ahmed Arsalan , Chen Jianyong , Zhang Huapeng
Published: January 2023

The main concern for the limited practical applications of strain-hardening cementitious composite, especially in China, is the high cost of imported materials, mainly polyvinyl alcohol fibers. This study uses local ingredients to develop strain-hardening cementitious composite reinforced with non-oil-coated Chinese polyvinyl alcohol fiber. The cementitious matrix consisting of cement, fly ash, viscosity-modifying agent, and silica fume was prepared, and the matrix tailoring was performed to achieve improved mechanical performance. The prepared composites were evaluated by rheology, three-point bending, and tensile characterizations. It is found that with the given local ingredients and matrix modification, the toughness index value of 100 ( I40) according to the American Society for Testing and Materials can be achieved. Besides, the tensile results showed the improvement of 45% and 60% for first-cracking strength and peak tensile strength values, respectively. The effects of matrix modification are also analyzed statistically using the analysis of variance for the mechanical properties of the cementitious composite. The post hoc statistical analysis using the Tukey–Kramer honestly significant difference illustrated the optimum cementitious mix from the experimental data. The presented results of cost-effective strain-hardening cementitious composite are expected to promote the practical applications of strain-hardening cementitious composite in China.
Cananga odorata Aromatherapy Reduces Anxiety in Unexperienced Patients Hospitalized for Interventional Neuroradiology Procedures: A Randomized Control Trial
Authors: Sriboonlert Jetsada , Munkong Waranon , Rintawut Sunantha , Paladkhua Soodjai , Suwongsa Ratchalita , Kirisattayakul Woranan
Published: January 2023

The hospitalization and the unfamiliar experiences of patients in interventional radiology procedures cause a moderate to high levels of anxiety. This study was aimed to evaluate the anxiolytic effect of Cananga odorata essential oil (COE) aromatherapy in unexperienced patients hospitalized for interventional neuroradiology (INR) procedures. Forty-four patients admitted for their first INR procedure were randomly divided into COE and placebo control groups. COE or distilled water was dropped onto 2 pieces of mulberry paper and attached to the participant's gown at the shoulder level overnight. The main outcomes were observed from the morning salivary cortisol levels and salivary alpha-amylase activity after intervention. The Thai version of Spielberger State-Trait Anxiety Inventory (STAI) and the vital signs (blood pressure and heart rate) were also assessed before and after COE intervention as the secondary outcome. The demographic and baseline data of both groups did not show any significant difference. After intervention, COE group had a significantly lower salivary alpha-amylase activity than placebo control group. The post-intervention scores of Trait (STAI-T) and State (STAI-S) anxiety were significantly less than those of baseline in both groups. Interestingly, the COE group had a greater percentage reduction on STAI-T after intervention than placebo control group. No significant difference was observed in other outcomes. In addition, the salivary alpha-amylase activity was weak but showed significant correlation with STAI anxiety scores. This study indicates that COE aromatherapy reduces the saliva alpha amylase activity and STAI-T anxiety in unexperienced patients hospitalized for INR procedures.
Risk of Gastric Cancer and Utility of Endoscopic Screening for Lynch Syndrome Patients
Authors: Bar-Mashiah Ariel , Ahsan Muhammad Danyal , McGonigle Rylee , Sharaf Ravi N.
Published: January 2023

Background:

Lynch syndrome (LS) is an autosomal dominant hereditary condition associated with a genetic predisposition to several cancers. Prior studies have shown an increased risk of gastric cancer (GC) in LS patients. The aim of this study was to synthesize the evidence for gastric cancer risk across Lynch syndrome-associated mutations and to assess the diagnostic utility of endoscopic screening for gastric cancer in these patients.

Methods:

A systematic literature review and meta-analysis of LS-associated gastric cancer risk and the diagnostic utility of endoscopic gastric cancer screening was conducted in accordance with PRISMA guidelines and GRADE methodology.

Results:

The results of this study found an elevated risk of GC in LS patients. Cumulative lifetime risk of GC in LS patients ranged from 2.6% to 38.7% when assessing across all LS mutations. Cumulative incidence ranged from 2.0% to 41.0%. When assessing cumulative incidence across specific LS mutations, MSH2 mutation carriers showed the highest cumulative incidence. RR across specific mutation carriers was generally highest in MSH2 carriers. A meta-analysis of 5 studies reporting diagnostic utility of endoscopic screening for gastric cancer in LS patients revealed a 2% incidence of GC (95% CI, 1.4%−2.9%).

Conclusions:

Gastric cancer risk in LS patients is greater than in the general population. Endoscopic screening yields low rates of GC in LS patients. Higher quality studies including RCTs are required to more accurately define GC risk and the yield of endoscopic surveillance in LS patients.
Platelet-Rich Plasma in Large Paraesophageal Hernia Repair: A Feasibility Study
Authors: James Tayler J. , Putnam Luke R. , Wisniowski Paul , Silva Jack P. , Chow Carol , Bildzukewicz Nikolai A. , Lipham John C.
Published: January 2023

Background:

The Achilles heel of antireflux surgery is hiatal hernia recurrence, and no treatment modalities to date have improved this outcome. Platelet-rich plasma (PRP) is an autologous therapy that promotes wound healing by upregulating extracellular matrix proteins, and it has excellent results in numerous surgical fields. Animal studies evaluating PRP use in hiatal hernia repair show favorable outcomes, yet its application in hiatal hernia repair in humans has not been described.

Methods:

This is a feasibility study of patients with large (>5 cm) paraesophageal hernia (PEH) who underwent PEH repair with PRP from 2/2021 to 1/2022. Safety, feasibility, and postoperative outcomes were investigated.

Results:

PRP was successfully administered during PEH repair in 12 consecutive patients. There were no significant adverse events. The methods for applying PRP to the repair were modified several times to optimize the technique. Administering PRP added an average of 5 minutes to the operative time. There were no significant postoperative complications or hernia recurrence on diagnostic imaging at latest follow up, with good subjective reflux control.

Conclusion:

PRP has excellent clinical outcomes in other surgical fields and may become an important new adjunct in antireflux surgery. This study shows PRP is safe and feasible in PEH repair, with little effect on operative time.
Darinaparsin in patients with relapsed or refractory peripheral T-cell lymphoma: results of an Asian phase 2 study
Authors: Kim Won-Seog , Fukuhara Noriko , Yoon Dok-Hyun , Yamamoto Kazuhito , Uchida Toshiki , Negoro Eiju , Izutsu Koji , Terui Yasuhito , Nakajima Hideaki , Ando Kiyoshi , Suehiro Youko , Kang Hye Jin , Ko Po-Shen , Nagahama Fumiko , Sonehara Yusuke , Nagai Hirokazu , Tien Hwei-Fang , Kwong Yok-Lam , Tobinai Kensei
Published: January 2023

Darinaparsin is a novel organic arsenical compound of dimethylated arsenic conjugated to glutathione, with antitumor activity and a mechanism of action markedly different from other available agents. This phase 2, nonrandomized, single-arm, open-label study evaluated the efficacy and safety of intravenous darinaparsin (300 mg/m2 over 1 hour, once daily for 5 consecutive days, per 21-day cycle) and its pharmacokinetics at multiple doses in 65 Asian patients with relapsed or refractory peripheral T-cell lymphoma (PTCL). The primary end point was the overall response rate (ORR). The ORR based on central assessment was 19.3% (90% confidence interval, 11.2-29.9), which was significantly higher than the predefined threshold of 10% (P = .024). The ORR was 16.2% in patients with PTCL–not otherwise specified and 29.4% in patients with angioimmunoblastic T-cell lymphoma. Tumor size decreased in 62.3% of patients. Treatment-emergent adverse events (TEAEs) were observed in 98.5% of patients. Grade ≥3 TEAEs with an incidence rate of ≥5% included anemia (15.4%), thrombocytopenia (13.8%), neutropenia (12.3%), leukopenia (9.2%), lymphopenia (9.2%), and hypertension (6.2%). Darinaparsin is effective and well tolerated, with TEAEs that were clinically acceptable and manageable with symptomatic treatment and dose reductions. This trial was registered at www.clinicaltrials.gov as #NCT02653976.
Return to work after medical rehabilitation in Germany: influence of individual factors and regional labour market based on administrative data
Authors: Hetzel Christian , Leinberger Sarah , Kaluscha Rainer , Kranzmann Angela , Schmidt Nadine , Mitschele Anke
Published: January 2023

Background

The influence of both individual factors and, in particular, the regional labour market on the return to work after medical rehabilitation is to be analyzed based on comprehensive administrative data from the German Pension Insurance and Employment Agencies.

Method

For rehabilitation in 2016, pre- and post-rehabilitation employment was determined from German Pension Insurance data for 305,980 patients in 589 orthopaedic rehabilitation departments and 117,386 patients in 202 psychosomatic rehabilitation departments. Labour market data was linked to the district of residence and categorized into 257 labour market regions. RTW was operationalized as the number of employment days in the calendar year after medical rehabilitation. Predictors are individual data (socio-demographics, rehabilitation biography, employment biography) and contextual data (regional unemployment rate, rehabilitation department level: percentage of patients employed before). The estimation method used was fractional logit regression in a cross-classified multilevel model.

Results

The effect of the regional unemployment rate on RTW is significant yet small. It is even smaller (orthopaedics) or not significant (psychosomatics) when individual employment biographies (i.e., pre-rehabilitation employment status) are inserted into the model as the most important predictors. The interaction with pre-rehabilitation employment status is not substantial.

Conclusions

Database and methods are of high quality, however due to the nonexperimental design, omitted variables could lead to bias and limit causal interpretation. The influence of the labour market on RTW is small and proxied to a large extent by individual employment biographies. However, if no (valid) employment biographies are available, the labour market should be included in RTW analyses.
How are hospitals in England caring for women at risk of preterm birth in 2021? The influence of national guidance on preterm birth care in England: a national questionnaire
Authors: Carlisle Naomi , Care Angharad , Anumba Dilly O. C. , Dalkin Sonia , Sandall Jane , Shennan Andrew H.
Published: January 2023

Background

National guidance (Saving Babies Lives Care Bundle Version 2 (SBLCBv2) Element 5) was published in 2019, with the aim to standardise preterm care in England. We plan to identify how many preterm birth surveillance clinics there are in England, and to define current national management in caring for women who are both asymptomatic and high-risk of preterm birth, and who arrive symptomatically in threatened preterm labour, to assist preterm management both nationally and internationally.

Methods

An online survey comprising of 27 questions was sent to all maternity units in England between February 2021 to July 2021.

Results

Data was obtained from 96 units. Quantitative analysis and free text analysis was then undertaken. We identified 78 preterm birth surveillance clinics in England, an increase from 30 preterm clinics in 2017. This is a staggering 160% increase in 4 years. SBLCBv2 has had a considerable impact in increasing preterm birth surveillance clinic services, with the majority (61%) of sites reporting that the NHS England publication influenced their unit in setting up their clinic. Variations exist at every step of the preterm pathway, such as deciding which risk factors warrant referral, distinguishing within particular risk factors, and offering screening tests and treatment options.

Conclusions

While variations in care still do persist, hospitals have done well to increase preterm surveillance clinics, under the difficult circumstances of the COVID pandemic and many without specific additional funding.
Assessment of integrated community case management of childhood illness (ICCM) practices by trained patent and proprietary medicine vendors (PPMVs) in Ebonyi and Kaduna states, Nigeria
Authors: Oko Akpu Blessing , Jennifer Anyanti , Chinyere Adizue Jane , Nelson Nwankwo Jehosephat , Omokhudu Idogho , Edward Onyezobi Chinedu , Dennis Aizobu
Published: January 2023

Introduction

An Integrated Community treatment of Childhood disease (ICCM)- focused intervention involving a large number of Patent and proprietary medicine vendors (PPMVs) was conducted by Society for Family Health Nigeria to improve management of childhood, malaria, pneumonia and diarrhea with an intervention approach focused on knowledge and skill improvement. The intervention was conducted in Kaduna and Ebonyi state; recruited and trained 15 interpersonal communication agents (IPCAs) who were saddled with the responsibility to sensitize and mobilize caregivers with children within the age bracket of 2 months to 5 years to our mapped PPMVs within the communities, on the account of Malaria, Diarrhea, and Pneumonia; while the IPCAs in return monitor the quality-of-service delivery. Following the intervention, the Society for Family health conducted a study to demonstrate the effectiveness of interventions such as ICCM training, supervision and linkage to quality ICCM commodities, among PPMVs to achieve high levels of knowledge and performance in diagnosing and treating common childhood illnesses.

Methods

Longitudinal research (before and after study) was adopted for the study. From the 387 PPMVs recruited and trained by SFH, 165 PPMVs were systematically selected to participate in the study, before and after the implementation of the intervention. Using SPSS version 22, data from the observation and completed questionnaires were analyzed and a chi-square test was used to examine the associations between the categorical information collected prior and after the intervention. The analysis was conducted at 5% level of significance.

Results

More than 50 % of the study participants were females (56.4%) and majority were either Junior community extension workers (35%) or Senior community extension worker (27%). About 21.8% trained PPMVs could not appropriately treat malaria in the first quarter of the intervention, however, there was a significant decrease to 1.8% in second quarter in the number of those that cannot appropriately diagnose and treat malaria. There was also a decrease in the number of those who could not treat cough and fast breathing from 47(28.5%) to 14(8.5%) in the second quarter and for diarrhea from 33.3% in the first quarter to 2.4% in the second quarter.

Conclusion

The study revealed a significant improvement in the quality of treatment provided by the trained PPMVs across the three disease areas. PPMVs in hard-to-reach areas should be trained and supported to continuously provide quality services to change the indices of under-5 mortality in Nigeria.
The potential human health hazard of nitrates in drinking water: a media discourse analysis in a high-income country
Authors: Grout Leah , Chambers Tim , Hales Simon , Prickett Marnie , Baker Michael G. , Wilson Nick
Published: January 2023

Background

Recent studies linking low levels of nitrate in drinking water to colorectal cancer have raised public concerns over nitrate contamination. The aim of this study was to analyze the media discourse on the potential human health hazard of nitrates in drinking water in a high-income country with a large livestock industry: New Zealand (NZ).

Methods

Searches of media sources (“major newspapers”) held by the Factiva database for the NZ setting in the five-year period 17 December 2016 to 20 December 2021.

Results

The largest number of media items was observed for 2017 (n = 108), the year of a NZ general election, with a notable decrease in 2020 (n = 20) that was likely due to the Covid-19 pandemic, which dominated health media. However, the percentage of these media items with a health focus steadily increased over time, from 11.1% of all articles in 2017 to 51.2% in 2021. The most commonly mentioned health hazard was colorectal cancer, followed by methemoglobinemia. The temporal pattern of media items suggests that the release of scientific studies and scholarly blogs was associated with the publication of subsequent media items. Major stakeholders involved in the discourse included representatives of local and central government, environmental and recreational interest groups, researchers, local residents, agricultural interest groups, and health organizations. Māori (Indigenous New Zealanders) values or perspectives were rarely mentioned.

Conclusions

Analysis of major newspapers for a five-year period indicated that a wide range of expert comment and opinions were made available to the public and policy makers on the issue of nitrates in water. While many different stakeholder views were captured in the media discourse, there is scope for the media to better report the views of Māori on this topic. There is also a need for articles detailing the health issues to also refer to the environmental, recreational, and cultural aspects of protecting water quality to ensure that the public, policy makers, and regulators are aware of co-benefits.
Site-specific nanomodulator capable of modulation apoptosis for enhanced colorectal cancer chemo-photothermal therapy
Authors: Wang Shuqi , Zhou Li , Tian Hailong , Li Bowen , Su Miao , Li Qiong , Nice Edouard C. , Huang Canhua , Shao Jichun , He Tao
Published: January 2023

Background

Colorectal cancer (CRC) is a common malignancy with the second highest mortality and the third highest morbidity worldwide. However, the overall survival of patients is unsatisfactory, thus requiring more effective clinical strategies. Celastrol (CLT), a natural bioactive compound, has been reported to induce reactive oxygen species (ROS)-mediated apoptosis to exhibit significant antitumor effects against CRC. However, the poor water solubility, low targeting ability, and bioavailability of CLT have limited its application, and CLT-induced protective autophagy weakens its therapeutic efficiency.

Results

We designed a targeted chemo-phototherapy nanoplatform (HCR NPs) to improve the application of CLT. The codelivery of IR820 and CLT in HCR NPs solved the water-soluble problem of CLT and enhanced apoptosis via IR820-mediated hyperthermia. In addition, hydroxychloroquine (HCQ) conjugated to hyaluronic acid (HA) not only increased the active targeting of HCR NPs but also inhibited CLT-induced protective autophagy to exacerbate apoptosis, thus achieving an amplified antitumor effect. Importantly, the HCR NPs exhibited an excellent therapeutic effect on CRC both in vitro and in vivo.

Conclusion

The HCR NPs presented in this study may not merely provide a new reference for the clinical application of CLT but also result in an attractive strategy for CRC treatment.
Hypofucosylation of Unc5b regulated by Fut8 enhances macrophage emigration and prevents atherosclerosis
Authors: Yang Xi , Ma Limei , Zhang Jun , Chen Linmu , Zou Zhen , Shen Di , He Hui , Zhang Lei , Chen Jun , Yuan Zhiyi , Qin Xia , Yu Chao
Published: January 2023

Background

Atherosclerosis (AS) is the leading underlying cause of the majority of clinical cardiovascular events. Retention of foamy macrophages in plaques is the main factor initiating and promoting the atherosclerotic process. Our previous work showed that ox-LDL induced macrophage retention in plaques and that the guidance receptor Uncoordinated-5 homolog B (Unc5b) was involved in this process. However, little is known about the role of Unc5b in regulating macrophage accumulation within plaques.

Results

In the present study, we found that Unc5b controls macrophage migration and thus promotes plaque progression in ApoE−/− mice. The immunofluorescence colocalization assay results first suggested that fucosyltransferase 8 (Fut8) might participate in the exacerbation of atherosclerosis. Animals with Unc5b overexpression showed elevated levels of Fut8 and numbers of macrophages and an increased lesion size and intimal thickness. However, these effects were reversed in ApoE−/− mice with Unc5b knockdown. Furthermore, Raw264.7 macrophages with siRNA-mediated silencing of Unc5b or overexpression of Unc5b were used to confirm the regulatory mechanisms of Unc5b and Fut8 in vitro. In response to ox-LDL exposure, Unc5b and Fut8 were both upregulated, and macrophages showed reduced pseudopod formation and migratory capacities. However, these capacities were restored by blocking Unc5b or Fut8. Furthermore, the IP assay indicated that Fut8 regulated the level of α-1,6 fucosylation of Unc5b, which mainly occurs in the endoplasmic reticulum (ER), and genetic deletion of the main fucosylation sites or Fut8 resulted in hypofucosylation of Unc5b. Moreover, the macrophage migration mediated by Unc5b depended on inactivation of the p-CDC42/p-PAK pathway. Conversely, macrophages with Unc5b overexpression displayed activation of the p-CDC42/p-PAK pathway and decreased migration both in vivo and in vitro.

Conclusion

These results demonstrated that hypofucosylation of Unc5b regulated by Fut8 is positively associated with the delay of the atherosclerotic process by promoting the migration of foamy macrophages. These findings identify a promising therapeutic target for atherosclerosis.
Job crafting interventions: what works, for whom, why, and in which contexts? Research protocol for a systematic review with coincidence analysis
Authors: Roczniewska Marta , Rogala Anna , Marszałek Magdalena , Hasson Henna , Bakker Arnold B. , von Thiele Schwarz Ulrica
Published: January 2023

Background

Recent challenges in the working world that resulted from the pandemic and technological advances have underlined the importance of flexibility in how jobs are designed. Job crafting (JC) refers to self-initiated changes that employees introduce to their jobs to optimize their job design and increase the fit between the job and their needs and preferences. These behaviors can be stimulated by job crafting training interventions, which aim to change how individual employees design, organize, or manage their work. However, since the interventions are implemented in various ways, we do not know which context and intervention factors are necessary or sufficient to achieve desired outcomes. Without this knowledge, benefitting from the potential of job crafting interventions is limited. The overall aim of this project will be to investigate what combinations of context, intervention, and mechanism factors are linked with effective JC interventions. Specifically, we will detect what factors are minimally sufficient and/or necessary to produce a successful JC intervention, how they combine, as well as what are the multiple alternative paths to their success.

Methods

We will perform a systematic review of the JC interventions literature combined with coincidence analysis (CNA). We will search electronic databases of journals and utilize Rayyan software to make decisions regarding inclusion. Data regarding context (e.g., fit), intervention (e.g., types of activities), mechanisms (e.g., intention implementation), and outcomes (e.g., employee well-being, job performance) will be extracted using a pre-piloted form and coded into a crisp-set (factor present vs. absent). Analyses will be carried out using the CNA package in R.

Discussion

This review will address gaps in knowledge about the context, intervention, and mechanism-related factors that may impact the effects of JC interventions. Consequently, this review will help develop a program theory for JC interventions that explains what works, how and under which circumstances. Applying CNA to synthesize these complex solutions across multiple studies provides an innovative method that may be used in future review attempts evaluating the implementation of interventions. Finally, our synthesis will provide knowledge relevant to organizational practitioners and scholars who want to implement JC interventions.

Trial registration

https://osf.io/2g6yx
Stress-rate-type strain-limiting models for solids resulting from implicit constitutive theory
Authors: Duman Emre , Şengül Yasemin
Published: January 2023

The main objective of this work is two-fold. First, we investigate the stress-rate-type implicit constitutive relations for solids within the context of strain-limiting theory of material response. The relations we study are models for generalisations of elastic bodies whose strain depends on the stress and the stress rate. Secondly, we obtain travelling-wave solutions for some special cases that are nonlinear in the stress. These are the first notion of solutions available in the literature for this type of models describing stress-rate-type materials.
Impact of the COVID-19 pandemic on burnout and perceived workplace quality among addiction treatment providers
Authors: Fentem Andrea , Riordan Raven , Doroshenko Christine , Li Xiao , Kasson Erin , Banks Devin , Winograd Rachel P. , Cavazos-Rehg Patricia
Published: January 2023

Background

This study examines the impact of the COVID-19 pandemic on work satisfaction, work-related stress, and perceived work quality among substance use treatment providers to better understand challenges faced among this group during the pandemic.

Methods

Participants of this study were 91 addiction treatment providers (e.g., therapists, physicians, community support specialists, administrative staff) recruited from various treatment facilities (e.g., inpatient and outpatient settings). Mixed method analyses were conducted to assess self-reported burnout, sources of work-related stress, and perceived work quality during the pandemic. Responses from providers reporting COVID-19 related decreases in work quality were compared to responses from providers who reported their quality of work had increased or remained the same.

Results

Results demonstrated half of providers (51%) reported their quality of work had decreased. This perceived decrease in quality of work was associated with higher levels of emotional exhaustion (M = 17.41 vs. M = 12.48, p = 0.002), workplace stress (M = 42.80 vs. M = 30.84, p = 0.001), as well as decreased enjoyment of work (83% vs. 51%, p = 0.001) and decreased personal accomplishment (M = 20.64 vs. M = 23.05 p = 0.001). Qualitative investigations further illustrated that increased hours, changes in work schedules, work-life balance challenges, difficulties with client communication, and increased client needs were contributing factors increasing stress/burnout and decreasing perceived work quality.

Conclusions

Addiction treatment providers experience high levels of burnout and workplace stress. Additionally, many individuals perceived a decrease in their quality of work during the COVID-19 pandemic. Addiction treatment facility administration should address these challenges to support the well-being of clinical staff and the clients they serve both during and after the COVID-19 pandemic.
Neurofilament light chain is increased in the parahippocampal cortex and associates with pathological hallmarks in Parkinson’s disease dementia
Authors: Frigerio Irene , Laansma Max A. , Lin Chen-Pei , Hermans Emma J. M. , Bouwman Maud M. A. , Bol John G. J. M. , Galis-de Graaf Yvon , Hepp Dagmar H. , Rozemuller Annemieke J. M. , Barkhof Frederik , van de Berg Wilma D. J. , Jonkman Laura E.
Published: January 2023

Background

Increased neurofilament levels in biofluids are commonly used as a proxy for neurodegeneration in several neurodegenerative disorders. In this study, we aimed to investigate the distribution of neurofilaments in the cerebral cortex of Parkinson’s disease (PD), PD with dementia (PDD) and dementia with Lewy bodies (DLB) donors, and its association with pathology load and MRI measures of atrophy and diffusivity.

Methods

Using a within-subject post-mortem MRI-pathology approach, we included 9 PD, 12 PDD/DLB and 18 age-matched control donors. Cortical thickness and mean diffusivity (MD) metrics were extracted respectively from 3DT1 and DTI at 3T in-situ MRI. After autopsy, pathological hallmarks (pSer129-αSyn, p-tau and amyloid-β load) together with neurofilament light-chain (NfL) and phosphorylated-neurofilament medium- and heavy-chain (p-NfM/H) immunoreactivity were quantified in seven cortical regions, and studied in detail with confocal-laser scanning microscopy. The correlations between MRI and pathological measures were studied using linear mixed models.

Results

Compared to controls, p-NfM/H immunoreactivity was increased in all cortical regions in PD and PDD/DLB, whereas NfL immunoreactivity was increased in the parahippocampal and entorhinal cortex in PDD/DLB. NfL-positive neurons showed degenerative morphological features and axonal fragmentation. The increased p-NfM/H correlated with p-tau load, and NfL correlated with pSer129-αSyn but more strongly with p-tau load in PDD/DLB. Lastly, neurofilament immunoreactivity correlated with cortical thinning in PD and with increased cortical MD in PDD/DLB.

Conclusions

Taken together, increased neurofilament immunoreactivity suggests underlying axonal injury and neurofilament accumulation in morphologically altered neurons with increased pathological burden. Importantly, we demonstrate that such neurofilament markers at least partly explain MRI measures that are associated with the neurodegenerative process.
Cerebellar granule neurons induce Cyclin D1 before the onset of motor symptoms in Huntington’s disease mice
Authors: Bauer Susanne , Chen Chwen-Yu , Jonson Maria , Kaczmarczyk Lech , Magadi Srivathsa Subramanya , Jackson Walker S.
Published: January 2023

Although Huntington’s disease (HD) is classically defined by the selective vulnerability of striatal projection neurons, there is increasing evidence that cerebellar degeneration modulates clinical symptoms. However, little is known about cell type-specific responses of cerebellar neurons in HD. To dissect early disease mechanisms in the cerebellum and cerebrum, we analyzed translatomes of neuronal cell types from both regions in a new HD mouse model. For this, HdhQ200 knock-in mice were backcrossed with the calm 129S4 strain, to constrain experimental noise caused by variable hyperactivity of mice in a C57BL/6 background. Behavioral and neuropathological characterization showed that these S4-HdhQ200 mice had very mild behavioral abnormalities starting around 12 months of age that remained mild up to 18 months. By 9 months, we observed abundant Huntingtin-positive neuronal intranuclear inclusions (NIIs) in the striatum and cerebellum. The translatome analysis of GABAergic cells of the cerebrum further confirmed changes typical of HD-induced striatal pathology. Surprisingly, we observed the strongest response with 626 differentially expressed genes in glutamatergic neurons of the cerebellum, a population consisting primarily of granule cells, commonly considered disease resistant. Our findings suggest vesicular fusion and exocytosis, as well as differentiation-related pathways are affected in these neurons. Furthermore, increased expression of cyclin D1 (Ccnd1) in the granular layer and upregulated expression of polycomb group complex protein genes and cell cycle regulators Cbx2, Cbx4 and Cbx8 point to a putative role of aberrant cell cycle regulation in cerebellar granule cells in early disease.
Risk assessment of city site landscapes in the central plains of China
Authors: Li Wei , Yang Ruixia , Yan Lijie , Xie Yihan , Liu Honghao , Chen Fulong
Published: January 2023

Scientific cognition and assessment of threats to cultural heritage and surrounding landscapes are prerequisites for targeted management and protection of cultural heritage. This study took 530 city sites in the Central Plains of China as the research object. Based on the survey information of city sites in the third national cultural heritage survey in China, a combination of high resolution google images and land use/land cover data products and city sites survey data enables a comprehensive evaluation of landscape elements impacts on city sites. With spatial statistical method, we divided city site landscape types, and constructed a landscape element risk assessment model and an urbanization intensity index to analyze the threats of each landscape element to city site protection. The results indicated that 40.64% of the sites are in farmland landscapes, where agricultural cultivation, irrigation, and other production activities may affect the surface and subsurface remains of the sites. The sites (16.82%) in urban landscapes are affected by activities such as building houses and roads. Only six sites belong to the water landscape area, which may be affected by water erosion. Other sites (2.84%) are mainly affected by plant root growth in forest landscapes. The city sites distributed in urban areas such as Zhengzhou or the urban–rural junction were significantly affected by urban expansion and got the greatest protection pressure. City sites in agricultural landscapes have the second highest conservation risk. Plant erosion and flooding mainly affected the city sites in the northwest-southwest mountainous areas or near the water area of the study area, and the risks were relatively small. It can be seen that landscape types such as urban and farmland, which are closely related to human activities, bring the most pressure to the protection of city sites, and it is necessary to focus on the impact of human activities such as urban construction on city sites and the surrounding environment in the future, while paying attention to the protection and rational use of city sites with high assessment risk in urban planning and management for the protection of the city site proper and landscape scenery.
Who is on the right track? Behavior-based prediction of diagnostic success in a collaborative diagnostic reasoning simulation
Authors: Richters Constanze , Stadler Matthias , Radkowitsch Anika , Schmidmaier Ralf , Fischer Martin R. , Fischer Frank
Published: January 2023

Background

Making accurate diagnoses in teams requires complex collaborative diagnostic reasoning skills, which require extensive training. In this study, we investigated broad content-independent behavioral indicators of diagnostic accuracy and checked whether and how quickly diagnostic accuracy could be predicted from these behavioral indicators when they were displayed in a collaborative diagnostic reasoning simulation.

Methods

A total of 73 medical students and 25 physicians were asked to diagnose patient cases in a medical training simulation with the help of an agent-based radiologist. Log files were automatically coded for collaborative diagnostic activities (CDAs; i.e., evidence generation, sharing and eliciting of evidence and hypotheses, drawing conclusions). These codes were transformed into bigrams that contained information about the time spent on and transitions between CDAs. Support vector machines with linear kernels, random forests, and gradient boosting machines were trained to classify whether a diagnostician could provide the correct diagnosis on the basis of the CDAs.

Results

All algorithms performed well in predicting diagnostic accuracy in the training and testing phases. Yet, the random forest was selected as the final model because of its better performance (kappa = .40) in the testing phase. The model predicted diagnostic success with higher precision than it predicted diagnostic failure (sensitivity = .90; specificity = .46). A reliable prediction of diagnostic success was possible after about two thirds of the median time spent on the diagnostic task. Most important for the prediction of diagnostic accuracy was the time spent on certain individual activities, such as evidence generation (typical for accurate diagnoses), and collaborative activities, such as sharing and eliciting evidence (typical for inaccurate diagnoses).

Conclusions

This study advances the understanding of differences in the collaborative diagnostic reasoning processes of successful and unsuccessful diagnosticians. Taking time to generate evidence at the beginning of the diagnostic task can help build an initial adequate representation of the diagnostic case that prestructures subsequent collaborative activities and is crucial for making accurate diagnoses. This information could be used to provide adaptive process-based feedback on whether learners are on the right diagnostic track. Moreover, early instructional support in a diagnostic training task might help diagnosticians improve such individual diagnostic activities and prepare for effective collaboration. In addition, the ability to identify successful diagnosticians even before task completion might help adjust task difficulty to learners in real time.
Uncertainties in physical properties of Itokawa-like asteroids widen constraints on their formation time
Authors: Hallstrom Jonas , Bose Maitrayee
Published: January 2023

One of the outstanding questions in planetary science is to determine how the fundamental mechanical and physical properties of materials determine the thermal evolution of asteroids, and which properties have the greatest influence. We investigate the effects of uncertainty in the material properties of asteroid parent bodies on the ability of thermal evolution models to constrain the sizes and formation times of ordinary chondrite parent asteroids. A simple model is formulated for the thermal evolution of the parent body of asteroid 25143 Itokawa. The effects of the uncertainties in the values specified for specific heat capacity, thermal diffusivity, and aluminum abundance are determined. The uncertainties in specific heat capacity and aluminum abundance, or heat production more generally, are found to both have significant and approximately equal effects on these results, substantially widening the range of possible formation times of Itokawa’s parent body. We show that Itokawa’s parent body could have formed between 1.6 and 2.5 million years after the origin of calcium–aluminum inclusions with a radius larger than 19 km, and it could have formed as early as 1.4 millions years, as late as 3.5 million years, or with a radius as small at 17 km if more lenient definitions of uncertainty in aluminum abundance are considered. These results stress the importance of precise data required of the material properties of a suite of LL type 4-6 ordinary chondrite meteorites to place better constraints on the thermal history of Itokawa’s parent body.

Graphical Abstract
Electroencephalographic monitoring of brain activity during cardiac arrest: a narrative review
Authors: Roberti Elisabetta , Chiarini Giovanni , Latronico Nicola , Adami Enrica Chiara , Plotti Chiara , Bonetta Elisa , Magri Federica , Rasulo Frank Anthony ,   the Coma following Cardiac ArreST study group (COAST)
Published: January 2023

Background

To date cardiac arrest (CA) remains a frequent cause of morbidity and mortality: despite advances in cardiopulmonary resuscitation (CPR), survival is still burdened by hypoxic–ischemic brain injury (HIBI), and poor neurological outcome, eventually leading to withdrawal of life sustaining treatment (WLST). The aim of CPR is cardiac pump support to preserve organ perfusion, until normal cardiac function is restored. However, clinical parameters of target organ end-perfusion during CPR, particularly brain perfusion, are still to be identified. In this context, electroencephalography (EEG) and its derivatives, such as processed EEG, could be used to assess brain function during CA.

Objectives

We aimed to review literature regarding the feasibility of EEG and processed or raw EEG monitoring during CPR.

Methods

A review of the available literature was performed and consisted of mostly case reports and observational studies in both humans and animals, for a total number of 22 relevant studies.

Results

The research strategy identified 22 unique articles. 4 observational studies were included and 6 animal testing studies in swine models. The remaining studies were case reports. Literature regarding this topic consists of conflicting results, containing studies where the feasibility of EEG during CPR was positive, and others where the authors reached opposite conclusions. Furthermore, the level of evidence, in general, remains low.

Discussion

EEG may represent a useful tool to assess CPR effectiveness. A multimodal approach including other non-invasive tools such as, quantitative infrared pupillometry and transcranial Doppler, could help to optimize the quality of resuscitation maneuvers.