bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical efficacy of 0.01% atropine in retarding the progression of myopia in children
Authors: Zhao Qi , Hao Qian
Published: November 2020

Purpose

To investigate the clinical efficacy of 0.01% atropine in slowing the progression of myopia in children and to evaluate the influence of 0.01% atropine on secretion of basal tear and stability of tear film.

Methods

Eighty children aged 5–14 years with myopia, 40 were randomly divided into two groups consisting of those who received spectacles in addition to 0.01% atropine (SA group) and those who received only spectacles (S group). The remaining 40 children who were wearing orthokeratology (OK) lenses for 3 months were randomly divided into two groups comprising those who received OK lenses in addition to 0.01% atropine (OKA group) and those who received only OK lenses (OK group). Comprehensive ophthalmologic examinations, including slit-lamp examination, visual acuity testing, autorefraction, intraocular pressure, axial length (AL), corneal topography, Schirmer’s test, and tear film break-up time (TBuT), were performed before treatment and after every 3 months treatment.

Results

During the follow-up visits, evidently better spherical equivalent (SE) control over 3, 6 and 12 months was observed in the SA and OKA groups compared with the S and OK groups. The AL over 3, 6, and 12 months was evidently inhibited in the SA and OKA groups compared with the S and OK groups. No statistically significant differences in Schirmer’s test and TBuT results were observed between the S and SA groups and between the OK and OKA groups. However, statistically significant differences were found in TBuT results between before treatment and after 3 months treatment in the OK group (P < 0.05, paired t test) and the OKA group (P < 0.05, paired t test).

Conclusions

0.01% atropine can effectively control myopia progression and axial elongation regardless of combined treatment with spectacles or OK lenses. And 0.01% atropine has no evident effect on Schirmer’s test and TBuT results; however, researchers also found that Schirmer’s test and TBuT results showed a tendency to reduce after treatment with 0.01% atropine.
Sensitivity to Social Agency in Autistic Adults
Authors: Morgan Emma J. , Foulsham Thomas , Freeth Megan
Published: November 2020

The presence of other people, whether real or implied, can have a profound impact on our behaviour. However, it is argued that autistic individuals show decreased interest in social phenomena, which leads to an absence of these effects. In this study, the agency of a cue was manipulated such that the cue was either described as representing a computer program or the eye movements of another participant. Both neurotypical and autistic participants demonstrated a social facilitation effect and were significantly more accurate on a prediction task when they believed the cue represented another participant. This demonstrates that whilst autistic adults may show difficulties in interpreting social behaviour this does not necessarily arise from a lack of sensitivity to social agency.
A Meta-analysis of Outcome Studies of Autistic Adults: Quantifying Effect Size, Quality, and Meta-regression
Authors: Mason David , Capp Simone J. , Stewart Gavin R. , Kempton Matthew J. , Glaser Karen , Howlin Patricia , Happé Francesca
Published: November 2020

Longitudinal studies have generally reported poor outcomes in adulthood for the majority of individuals (c.50–60%) with autism. Several factors putatively predict outcome (e.g. IQ), but findings remain mixed. This paper presents an updated meta-analysis of autism outcome studies and extends previous findings with additional analyses (including meta-regression). A total of 4088 records was screened and 18 studies, involving 1199 individuals, were included in the quantitative analysis. Estimated percentages indicated that 20.0% of participants were rated as having a good outcome, 26.6% a fair outcome, and 49.3% a poor outcome. Meta-regression indicated that lower IQ in adulthood was predictive of poor outcome; other meta-regression models did not survive correction for multiple comparisons. Overall, outcomes for autistic people are on average poor, and higher IQ appears to be protective against having a poor outcome. The limitations of current constructs of outcome are discussed.
Prospects for upgrading by the European kelp sector
Authors: van den Burg Sander , Selnes Trond , Alves Liliana , Giesbers Else , Daniel Ana
Published: November 2020

The interest in cultivating seaweed in European seas as source of food, feed and feedstock for the biobased economy is growing. Amongst the species investigated is kelp, also known as sugar kelp, Saccharina latissima or Laminaria saccharina. The European kelp sector is relatively small, compared to the global production and use, yet growth of the sector is aimed for. An inevitable question for European seaweed producers is how they can compete in the global seaweed value chain. This paper assesses to what extent the European strategy for growing the kelp sector matches with the dynamics of current kelp value chain. The global value chains (GVC) framework is applied to study how the global kelp sector is organized, including analysis of trends in science and patents. The upgrading strategy deployed by the European sector is critically evaluated against this framework. The analysis points towards various dividing lines between the established kelp cultivation and processing industry in Asia and the (far smaller) nascent cultivation and processing industry for high-value applications. These represent two unconnected worlds. Chain or intra-sectoral upgrading to spur the European kelp sector could occur if European food sector engage more closely with the European producers. Those bring financial power and a broader client base to the table and are instrumental in linking production to the demands of end-users.
Dynamical Phase Transitions for Flows on Finite Graphs
Authors: Gabrielli Davide , Renger D. R. Michiel
Published: November 2020

We study the time-averaged flow in a model of particles that randomly hop on a finite directed graph. In the limit as the number of particles and the time window go to infinity but the graph remains finite, the large-deviation rate functional of the average flow is given by a variational formulation involving paths of the density and flow. We give sufficient conditions under which the large deviations of a given time averaged flow is determined by paths that are constant in time. We then consider a class of models on a discrete ring for which it is possible to show that a better strategy is obtained producing a time-dependent path. This phenomenon, called a dynamical phase transition, is known to occur for some particle systems in the hydrodynamic scaling limit, which is thus extended to the setting of a finite graph.
Preferential Engagement and What Can We Learn from Online Chess?
Authors: Kulikov Vadim
Published: November 2020

An online game of chess against a human opponent appears to be indistinguishable from a game against a machine: both happen on the screen. Yet, people prefer to play chess against other people despite the fact that machines surpass people in skill. When the philosophers of 1970’s and 1980’s argued that computers will never surpass us in chess, perhaps their intuitions were rather saying “Computers will never be favored as opponents”? In this paper we analyse through the introduced concepts of psychological affordances and psychological interplay, what are the mechanisms that make a human-human (HH) interaction more meaningful than a human-computer (HC) interaction. We claim that an HH chess game consists of two intertwined, but independent simultaneous games—only one of which is retained in the HC game. To help with the analysis we introduce the thought experiment of a Preferential Engagement Test (PET) which is inspired by, but non-equivalent to, the Standard Turing Test. We also explore how the PET can illuminate, and be illuminated by, various philosophies of mind reading: Theory Theory, Simulation Theory and Mind Minding. We propose that our analysis along with the concept of PET could illuminate in a new way the conditions and challenges a machine (or its designers) must face before it can replace humans in a given occupation.
The Pragmatic and Stylistic Aspects of Communication Between State Authorities and the Citizen within e-Administration in Poland
Authors: Kowalczyk Joanna
Published: November 2020

This article discusses the specificity of remote communication between state authorities and citizens as part of e-administration services. Attention was paid to the available technological tools used in state-citizen communication (e.g. applications, help centres), but most of all, the focus was on the pragmatics of creating messages in the “digital office”. The aim of the present study was to identify the main linguistic and quasi-linguistic instruments that build the stylistic and pragmatic formula of e-administration in Poland. The source material was taken from the widely available and most popular e-administration platforms, containing detailed information on services provided by public administration and enabling the citizen to establish remote contact with the state, such as Obywatel.gov.pl, ePUAP.gov.pl, CEIDG.gov.pl and Biznes.gov.pl.
Perceptualism and the epistemology of normative reasons
Authors: Müller Jean Moritz
Published: November 2020

According to much recent work in metaethics, we have a perceptual access to normative properties and relations. On a common approach, this access has apresentationalcharacter. Here, ‘presentational’ specifies a characteristic feature of the way aspects of the environment are apprehended in sensory experience. While many authors have argued that we enjoy presentations of value properties, thus far comparatively less effort has been invested into developing a presentational view of the apprehension of normative reasons. Since it appears that this view would offer much the same theoretical benefits as presentational views of the apprehension of value, it seems worthwhile redressing this imbalance. My paper aims at doing so, focusing on concern-dependent practical reasons. After clarifying the central commitment of this view, I assess a recent proposal by Dancy (Ethics 124(4):787-812, 2014) which provides a detailed characterization of the relevant type of cognition. I argue that Dancy ignores one of the central features of a presentational access to normative reasons and therefore misidentifies which actual psychological phenomena are apt to play this role. In this context, I also assess and reject further candidates that might seem fitting for this purpose. In the remainder of the paper, I then offer a more adequate account which specifies an actual form of presentational access to concern-dependent practical reasons and provide the contours of a more substantive account of its nature.
Plastic Deformation of Rough Metallic Surfaces
Authors: Tiwari A. , Almqvist A. , Persson B. N. J.
Published: November 2020

The contact between rough metallic bodies almost always involves plastic flow in the area of real contact. We performed indentation experiments on sandblasted aluminum surfaces to explore the plastic deformation of asperities and modeled the contact mechanics using the boundary element method, combined with a simple numerical procedure to take into account the plastic flow. The theory can quantitatively describe the modification of the roughness by the plastic flow. Since the long-wavelength roughness determines the fluid leakage of metallic seals in most cases, we predict that the leakage can be estimated based on the elastoplastic contact mechanics model employed here.
Oral administration of Jumihaidokuto inhibits UVB-induced skin damage and prostaglandin E2 production in HR-1 hairless mice
Authors: Murata Kenta , Oyama Manami , Ogata Misaki , Fujita Nina , Takahashi Ryuji
Published: November 2020

This study was conducted to investigate whether and how Jumihaidokuto (JHT), a traditional Chinese medicine, prevents UVB-induced skin damage in male HR-1 hairless mice. JHT has been traditionally prescribed for patients presenting skin disorders with redness and swelling, and, in Japan, it is approved for prescription to patients with acute and/or purulent skin disorders, hives, acute eczema, and athlete’s foot. Considering the traditional use of JHT, we hypothesized that oral administration of JHT might emerge as an effective strategy to prevent UVB-induced skin damage, such as edema and erythema. Here, we pretreated mice with JHT (1000 mg/kg, p.o.) for 3 weeks and then administered a single dose of UVB irradiation (250 mJ/cm2) on the dorsal skin. UVB irradiation increased the erythema index and transepidermal water loss (TEWL) and decreased the skin water content in the epidermis at 72 h post-irradiation. JHT treatment inhibited the increase of TEWL and the loss of water content in the epidermis, but not the elevation of the erythema index. Moreover, administration of JHT suppressed UVB-induced epidermal hyperplasia by blocking the proliferation of keratinocytes and also inhibited irradiation-triggered reduction of collagen fibers and infiltration of immune cells into the dermis. Lastly, administration of JHT suppressed UVB-induced production of proinflammatory mediators, such as prostaglandin E2 and interleukin-1β. These results suggest that JHT prevents UVB-induced skin damage and that the underlying mechanism involves the inhibition of proinflammatory mediators.
Designing teacher professional development programs to support a rapid shift to digital
Authors: Heap Tania , Thompson Ruthanne , Fein Adam
Published: November 2020

From a design perspective, this paper offers a response to the impact, value, and application of a manuscript published by Philipsen et al. (Improving teacher professional development for online and blended learning: A systematic meta-aggregative review. Educational Technology and Research Development, 67, 1145–1174. 10.1007/s11423-019-09645-8, 2019). Philipsen et al. (2019) reviewed what constitutes an effective teacher professional development program (TPD) for online and blended learning (OBL), with our response focusing on its value and application in light of an emergency shift to digital to address a global pandemic. This paper also proceeds to examine limitations in previous research into the subject and future research opportunities to investigate important components that inform the design of a resilient and scalable TPD for OBL.
Visible verbal morphology: Morpheme constancy in Germanic and Romance verbal inflection
Authors: Fuhrhop Nanna
Published: November 2020

In different spelling systems, different grades of morpheme constancy can be found: German has a high degree of morpheme constancy (especially stem constancy, for example rennen – rennt both forms with ), while English has comparatively less (running – run, only the disyllabic form with ). This paper investigates the interaction between stems and verbal inflectional suffixes in terms of constancy in three Germanic languages (Dutch, English, German) and five Romance languages (French, Italian, Portuguese, Romanian, Spanish). Verbal inflection is always the most widespread inflection, so it is a well-defined area for getting an idea of how spelling systems may function. For the Germanic languages, this analysis will primarily focus on the alternation between monosyllabic and disyllabic forms. For the Romance languages, it will focus on the / -alternations in interaction with the following vowel. The aim is to describe a scale of morphological spelling: The alternation of  and <ç> is not an instance of constancy, but of similarity, something between constancy and non-constancy. Morpheme constancy is no longer a binary feature. Comparing verbal inflection takes us another step towards the development of typological parameters for visible morphology.
Evaluation of Hot Workability of Powder Metallurgy Ni-Based Superalloy with Different Initial Microstructures
Authors: Higashi Masaya , Kanno Naoya
Published: November 2020

The effect of the initial microstructure on the hot workability of a powder metallurgy Ni-based superalloy was investigated in the high-temperature range of 950 °C to 1180 °C and strain rate range of 0.001 to 1.0 s−1. Six samples with different initial microstructures were fabricated by various hot isostatic pressing (HIP) conditions and subsequent treatments such as hot extrusion. The coarse-grained samples exhibited low hot workability regardless of the deformation conditions. In contrast, the hot workability of the fine-grained samples significantly varied depending on the deformation conditions. The hot workability exhibited a peak at the sub-solvus temperature of ~ 1100 °C and decreased at temperatures higher and lower than this temperature. In addition, the hot workability decreased monotonically with increasing the strain rate. The prior particle boundaries (PPBs) acted as cavity nucleation sites and crack paths, especially at lower temperatures and higher strain rates, resulting in early fracture and low hot workability. With decreasing the grain size, the hot workability at the peak temperature improved. The extruded sample with the smallest grain size exhibited the best hot workability, owing to the avoidance of PPB fracture and the acceleration of dynamic recrystallization.
Changes in sleep schedule and chronotype due to COVID-19 restrictions and home office
Authors: Staller Naomi , Randler Christoph
Published: November 2020

Background and objective

In this study, we researched the effects of the COVID-19 restriction measures on the sleep health of N = 681 German residents (mean age: 28.63 years, SD: 10.49 years).

Methods

The data were collected with an anonymous online survey composed of validated questionnaires and additional questions to quantify changed circumstances during the pandemic. Data were collected from May 18 to June 17, 2020, while governmental restrictions were imposed in Germany. We exclusively analysed participants working in home office during this time.

Results

Participants woke up about 1 hour later during the COVID-19 restriction phase, while going to bed at almost the same time as before. During the week, participants slept about an hour longer, while sleep at weekends did not differ significantly. Social jetlag decreased from 1:39 ± 1:00 to 0:49 ± 0:42 min in our sample. The number of children in the household was a significant factor predicting sleep timing. Participants with children living in the same household slept longer and sleep onset was later.

Conclusion

In terms of sleep behaviour and, consequently, sleep health, participants benefited from the transition to home office. They were able to adapt their waking and working hours better to their biological rhythm, which reduced social jetlag.
Be aware, make it clear, and take the Lead: emotion regulation difficulties and emotional intelligence as moderators of cognitive reappraisal
Authors: Bodrogi Barbara , Bereczkei Tamas , Deak Anita
Published: November 2020

Two research traditions explain the way we deal with emotional situations: emotional intelligence (EI) and emotion regulation (ER). EI refers to the individual differences in the knowledge, identification, and regulation of emotions. ER describes processes in which emotions are experienced, expressed, and altered. Our study examined the EI-ER link and their moderating role on affective responses. We used self-report questionnaires and a cognitive reappraisal (CR) task, in which subjective affective responses were registered. We found that higher levels of ER difficulties correlated with lower EI. Gender had an overall impact on affective changes, indicating a more unpleasant and more arousing affective state for women compared with men. Regarding the moderating role of EI and ER difficulties, the ability to utilize emotions (Utilization) decreased the valence into a more unpleasant direction, similar to the effect of the inability to identify and differentiate emotions (Clarity). A weak control over emotions (Impulse), however, increased the valence into a more pleasant direction. The lack of attention to emotional signals (Awareness) marginally decreased the initial intensity (i.e., lower level of arousal). We demonstrated that EI and ER have distinctive routes and a different influence on the affective outcome defined by valence and arousal ratings: (1) EI has an impact through the utilization of emotions mainly on the valence dimension; and (2) individual differences in ER have a moderating effect on both valence and arousal dimensions. This study provided evidence on how individual differences contribute to a successful ER process when using a CR strategy.
Cortisol induces masculinization of XX medaka through gonadal soma-derived growth factor (GSDF) and anti-Müllerian hormone receptor type 2 (AMHR2)
Authors: Hara Seiji , Sawamura Rie , Kitano Takeshi
Published: November 2020

The medaka Oryzias latipes is a teleost fish with an XX/XY sex determination system similar to that of mammals. However, under high-temperature conditions, XX medaka are masculinized by an elevation of the key teleost glucocorticoid, cortisol. Cortisol inhibits female-type proliferation of germ cells and induces masculinization of XX medaka during gonadal sex differentiation. To identify masculinization mechanisms downstream of cortisol, we analysed the functions of gonadal soma-derived growth factor (gsdf) and anti-Müllerian hormone receptor type 2 (amhr2); these genes are known to play important roles in the inhibition of germ cell proliferation and male differentiation. We investigated the impact of gsdf and amhr2 on the proliferation of germ cells using gsdf knockout (KO) and amhr2 KO medaka. At hatching stage, loss of gsdf or amhr2 function recovered female-type proliferation in germ cells under cortisol treatment. Moreover, cortisol treatment of gsdf KO or amhr2 KO medaka did not induce masculinization of XX medaka. These results suggest that cortisol inhibits female-type proliferation of germ cells and induces masculinization of XX medaka through GSDF and AMHR2. This study thereby provides the first evidence that GSDF and AMHR2 are involved in cortisol-induced masculinization.
“Think from the perspective of the reader” and other insiders’ perspectives for scholars in isolation
Authors: Driessen Erik W.
Published: November 2020

None
Determination of coefficients of friction for laminated veneer lumber on steel under high pressure loads
Authors: Dorn Michael , Habrová Karolína , Koubek Radek , Serrano Erik
Published: November 2020

In this study, static coefficients of friction for laminated veneer lumber on steel surfaces were determined experimentally. The focus was on the frictional behaviors at different pressure levels, which were studied in combination with other influencing parameters: fiber orientation, moisture content, and surface roughness. Coefficients of friction were obtained as 0.10–0.30 for a smooth steel surface and as high as 0.80 for a rough steel surface. Pressure influenced the measured coefficients of friction, and lower normal pressures yielded higher coefficients. The influence of fiber angle was observed to be moderate, although clearly detectable, thereby resulting in a higher coefficient of friction when sliding perpendicular rather than parallel to the grain. Moist specimens contained higher coefficients of friction than oven-dry specimens. The results provide realistic values for practical applications, particularly for use as input parameters of numerical simulations where the role of friction is often wrongfully considered.
Factors Predictive of Behavioural and Emotional Dysfunction in Adolescents in a Secure Children’s Home
Authors: Harris Rebecca , Stubbings Daniel R. , De Claire Karen
Published: November 2020

The aim of the present study was to investigate what factors are predictive of behavioural and emotional dysfunction in adolescence. A sample of 60 young people accommodated under a welfare or youth custody service order in a UK secure children’s home between 2016 and 2018 was used. Data regarding young people’s Adverse Childhood Experiences (ACE’s) history, scores on standard assessments and factors thought to indicate behavioural and emotional dysfunction were collected from file information. Correlations and regression models were used to analyse the data. Analyses found that young people in this setting had been exposed to more ACEs than the general population. Furthermore, signs of behavioural and emotional dysfunction as a result of exposure to ACE’s appeared to be present from early adolescence. It was found that exposure to verbal and sexual abuse were the greatest predictors of involvement in risk incidents. The young person’s substance misuse habits were the best predictor of the length of stay in the secure children’s home. These findings may have policy implications and highlight the need for early interventions with young people exposed to ACE’s.
The Correspondence of Isaac Newton
Authors: Newton Isaac
Published: November 2020

This fifth volume presents the surviving correspondence from the period of almost four years which is, from a bibliographical point of view, the most important time in Newton's life: with Roger Cotes, Newton revised his Philosophise Naturalis Principia Mathematics and saw it through the press. Considered as a single group of letters, the Newton-Cotes correspondence is the largest and most important section of Newton's scientific correspondence that we have. Nowhere else can one witness Newton in a detailed debate about scientific argument and scientific conclusions – a debate from which he did not always emerge victorious. Nowhere else does Newton write in detail about the text of the Principia. And all scholars agree that this text which was hammered out between Cotes and Newton was the most important of all versions, printed and unprinted; this was (to all intents and purposes) the Principia of subsequent history.
The Correspondence of Isaac Newton
Authors: Newton Isaac
Published: November 2020

In this seventh and final volume the letters are divided into two quite distinct groups. The first group begins with the remaining letters of the main chronological sequence written during the closing years of Newton's life, and then proceeds to those few letters to which there is no assignable date with any certainty. The second group of letters, placed in Appendix I, contains corrections and additions to the letters printed in the earlier volumes of the Correspondence. A genealogical table is added to Appendix II to help the reader through the intricacies of Newton's family tree. Even after the creative power of his genius had deserted him, Newton retained to the very end of his long life the characteristic clarity of his thought. Few of Newton's letters in this volume may justly be described as scientific. The relative inactivity of the Mint meant that, although he apparently delegated few of his responsibilities to others, Newton's concerns there were no onerous. Thus it is not surprising that in the last nine years of his life (the period covered in this volume), and particularly from 1725 onwards, there was a decrease in Newton's output of letters; but those which he did write remain as lucid as ever.
Free-baiting: policy applications for freeness removal and the zero price effect
Authors: LOWENS ETHAN
Published: November 2020

This paper explores “free-baiting” as a behavioral policy tool for reducing participation in socially undesirable activities. Empirical evidence establishes that when a good or activity ceases to be free, consumption plummets. A free-baiting policy creates conditions of freeness in order to subsequently take advantage of the discouraging effects of freeness removal. The initial free phase shifts consumers’ reference price for the target activity to zero. Subsequently, prices are returned to market levels – a staggering price increase. Behavioral factors enhance the salience of that price increase. It occurs along the steepest part of the money utility curve. It is especially salient because it is presented as a loss. In addition, it may trigger the endowment effect: forcing people to give something up in order to partake in the target activity once it is no longer free. Moreover, these discouraging effects can enhance the efficiency and effectiveness of other interventions. Free-baiting manufactures a policy window, creating a moment in which many consumers simultaneously confront obstacles to the target activity. The effects of free-baiting are illustrated using several hypothetical interventions, including rush-hour roadway tolls, sugary beverages, gasoline and tobacco.
A tEEG framework for studying designer’s cognitive and affective states
Authors: Zhao Mengting , Jia Wenjun , Yang Daocheng , Nguyen Philon , Nguyen Thanh An , Zeng Yong
Published: November 2020

This paper proposes a task-related electroencephalogram research framework (tEEG framework) to guide scholars’ research on EEG-based cognitive and affective studies in the context of design. The proposed tEEG framework aims to investigate design activities with loosely controlled experiments and decompose a complex design process into multiple primitive cognitive activities, corresponding to which different research hypotheses on basic design activities can be effectively formulated and tested. Thereafter, existing EEG techniques and methods can be applied to analyse EEG signals related to design. Three application examples are presented at the end of this paper to demonstrate how the proposed framework can be applied to analyse design activities. The tEEG framework is presented to guide EEG-based cognitive and affective studies in the context of design. Existing methods and models are summarized, for the effective application of the tEEG framework, from the current literature spread in a wide spectrum of resources and fields.
Perioperative antimicrobial prophylaxis in adult patients: The first multicenter clinical practice audit with intervention in Greek surgical departments
Authors: Chorafa Elisavet , Iosifidis Elias , Tsiodras Sotirios , Skoutelis Athanasios , Kourkouni Eleni , Kopsidas Ioannis , Tsopela Grammatiki-Christina , Chorianopoulou Evangelia , Triantafyllou Christos , Kourlaba Georgia , Zaoutis Theoklis , Roilides Emmanuel ,   for the Preventing Hospital-Acquired Infections in Greece (PHiG) investigators
Published: November 2020

Objective:

To audit clinical practice and implement an intervention to promote appropriate use of perioperative antimicrobial prophylaxis (PAP).

Design:

Prospective multicenter before-and-after study.

Setting:

This study was conducted in 7 surgical departments of 3 major Greek hospitals.

Methods:

Active PAP surveillance in adults undergoing elective surgical procedures was performed before and after implementation of a multimodal intervention. The surveillance monitored use of appropriate antimicrobial agent according to international and local guidelines, appropriate timing and duration of PAP, overall compliance with all 3 parameters and the occurrence of surgical site infections (SSIs). The intervention included education, audit, and feedback.

Results:

Overall, 1,447 patients were included: 768 before and 679 after intervention. Overall compliance increased from 28.2% to 43.9% (P = .001). Use of antimicrobial agents compliant to international guidelines increased from 89.6% to 96.3% (P = .001). In 4 of 7 departments, compliance with appropriate timing was already >90%; an increase from 44.3% to 73% (P = .001) and from 20.4% to 60% (P = .001), respectively, was achieved in 2 other departments, whereas a decrease from 64.1% to 10.9% (P = .001) was observed in 1 department. All but one department achieved a shorter PAP duration, and most achieved duration of ~2 days. SSIs significantly decreased from 6.9% to 4% (P = .026). After the intervention, it was 2.3 times more likely for appropriate antimicrobial use, 14.7 times more likely to administer an antimicrobial for the appropriate duration and 5.3 times more likely to administer an overall appropriate PAP.

Conclusion:

An intervention based on education, audit, and feedback can significantly contribute to improvement of appropriate PAP administration; further improvement in duration is needed.
Parties on the Left, Parties on the Right: Electoral Competition and Citizenship Policy Change in Europe
Authors: Graeber John
Published: November 2020

In recent decades, citizenship policies in Europe have changed significantly: some governments have introduced restrictive new requirements for citizenship, while others have made citizenship more accessible. What explains this variation? Despite a burgeoning literature on both comparative citizenship and spatial competition among parties, scholarship on this question remains in its infancy and primarily focused on the influence of the far right. Expanding on this growing research, this article argues that citizenship policy change results from electoral competition on both sides of the political spectrum, in conjunction with governments’ ideological orientation. Using new data on citizenship policies across sixteen European countries from 1975 to 2014, the author demonstrates that left-of-center governments facing increasing levels of left party competition are associated with more accessible policy changes, while increasing levels of party competition from the far right yield more restrictive policy changes under not only right-of-center governments, but also centrist and left-of-center governments as well.
Recovering the Augustinian Convent of San Salvatore in Venetian Candia
Authors: ILKO KRISZTINA
Published: November 2020

This study investigates the place of San Salvatore in the holy topography of Venetian Candia. By focusing on the largest convent in the Augustinian Province of the Holy Land, it contributes to a better understanding of a neglected subject in mendicant scholarship, namely the Augustinian friars’ expansion in the eastern Mediterranean. This article offers a detailed reconstruction of the demolished building and its sacred space, and sheds new light on interaction among the mixed Latin-Greek population in Venetian Crete by examining icons, altars, liturgy and, in particular, the introduction of the cult of Nicholas of Tolentino.
Is borderline personality disorder really an emotion dysregulation disorder and, if so, how? A comprehensive experimental paradigm
Authors: Fitzpatrick Skye , Varma Sonya , Kuo Janice R.
Published: November 2020

Background

Leading theories suggest that borderline personality disorder (BPD) is an emotion dysregulation disorder involving lower basal vagal tone, higher baseline emotion, heightened emotional reactivity, delayed emotional recovery, and emotion regulation deficits. However, the literature to date lacks a unifying paradigm that tests all of the main emotion dysregulation components and comprehensively examines whether BPD is an emotion dysregulation disorder and, if so, in what ways. This study addresses the empirical gaps with a unified paradigm that assessed whether BPD is characterized by five leading emotion dysregulation components compared to generalized anxiety disorder (GAD) and healthy control (HC) groups.

Methods

Emotion was assessed across self-report, sympathetic, and parasympathetic indices. Participants with BPD, GAD, and HCs (N= 120) first underwent baseline periods assessingbasal vagal toneandbaseline emotional intensity, followed by rejection-themed stressors assessingemotional reactivity. Participants then either reacted normally to assessemotional recoveryor attempted to decrease emotion using mindfulness or distraction to assessemotion regulation implementation deficits.

Results

Individuals with BPD and GAD exhibited higher self-reported and sympathetic baseline emotion compared to HCs. The BPD group also exhibited self-reported emotion regulation deficits using distraction only compared to the GAD group.

Conclusions

There is minimal support for several emotion dysregulation components in BPD, and some components that are present appear to be pervasive across high emotion dysregulation groups rather than specific to BPD. However, BPD may be characterized by problems disengaging from emotion using distraction.
Meta-analyzing the prevalence and prognostic effect of antipsychotic exposure in clinical high-risk (CHR): when things are not what they seem
Authors: Raballo Andrea , Poletti Michele , Preti Antonio
Published: November 2020

Background

The clinical high-risk (CHR) for psychosis paradigm is changing psychiatric practice. However, a widespread confounder, i.e. baseline exposure to antipsychotics (AP) in CHR samples, is systematically overlooked. Such exposure might mitigate the initial clinical presentation, increase the heterogeneity within CHR populations, and confound the evaluation of transition to psychosis at follow-up. This is the first meta-analysis examining the prevalence and the prognostic impact on transition to psychosis of ongoing AP treatment at baseline in CHR cohorts.

Methods

Major databases were searched for articles published until 20 April 2020. The variance-stabilizing Freeman-Tukey double arcsine transformation was used to estimate prevalence. The binary outcome of transition to psychosis by group was estimated with risk ratio (RR) and the inverse variance method was used for pooling.

Results

Fourteen studies were eligible for qualitative synthesis, including 1588 CHR individuals. Out of the pooled CHR sample, 370 individuals (i.e. 23.3%) were already exposed to AP at the time of CHR status ascription. Transition toward full-blown psychosis at follow-up intervened in 112 (29%; 95% CI 24–34%) of the AP-exposed CHR as compared to 235 (16%; 14–19%) of the AP-naïve CHR participants. AP-exposed CHR had higher RR of transition to psychosis (RR = 1.47; 95% CI 1.18–1.83; z = 3.48; p = 0.0005), without influence by age, gender ratio, overall sample size, duration of the follow-up, or quality of the studies.

Conclusions

Baseline AP exposure in CHR samples is substantial and is associated with a higher imminent risk of transition to psychosis. Therefore, such exposure should be regarded as a non-negligible red flag for clinical risk management.
ATOP THE KADMEIA: MYCENAEAN ROOF TILES FROM THEBES IN CONTEXT
Authors: Aravantinos Vassilis L. , Fappas Ioannis , Galanakis Yannis
Published: November 2020

Questions were raised in the past regarding the use of Mycenaean tiles as ‘roof tiles’ on the basis of the small numbers of them recovered in excavations and their overall scarcity in Mycenaean domestic contexts. The investigation of the Theodorou plot in 2008 in the southern part of the Kadmeia hill at Thebes yielded the single and, so far, largest known assemblage per square metre of Mycenaean tiles from a well-documented excavation. This material allows, for the first time convincingly, to identify the existence of a Mycenaean tiled roof. This paper presents the results of our work on the Theodorou tiles, placing emphasis on their construction, form and modes of production, offering the most systematic study of Mycenaean tiles to date. It also revisits contexts of discovery of similar material from excavations across Thebes. Popular as tiles might have been in Boeotia, and despite their spatially widespread attestation, their use in Aegean Late Bronze Age architecture appears, on the whole, irregular with central Greece and the north-east Peloponnese being the regions with the most sites known to have yielded such objects. Mycenaean roof tiles date mostly from the mid- and late fourteenth centurybcto the twelfth centurybc. A study of their construction, form, production and contexts suggests that their role, apart from adding extra insulation, might have been one of signposting certain buildings in the landscape. We also present the idea that Mycenaean tile-making was guided by a particular conventional knowledge which was largely influenced by ceramic-related technologies (pottery- and drain-making). While production of roof tiles might have been palace-instigated to begin with, it does not appear to have been strictly controlled. This approach to Mycenaean tile-making may also help explain their uneven (in terms of intensity of use) yet widespread distribution.
What categorical induction variability reveals about typical and atypical development
Authors: TECOULESCO Lisa , FEIN Deborah , NAIGLES Letitia R.
Published: November 2020

Categorical induction abilities are robust in typically developing (TD) preschoolers, while children with Autism Spectrum Disorders (ASD) frequently perform inconsistently on tasks asking for the transference of traits from a known category member to a new example based on shared category membership. Here, TD five-year-olds and six-year-olds with ASD participated in a categorical induction task; the TD children performed significantly better and more consistently than the children with ASD. Concurrent verbal and nonverbal tests were not significant correlates; however, the TD children's shape bias performance at two years of age was significantly positively predictive of categorical induction performance at age five. The shape bias, the tendency to extend a novel label to other objects of the same shape during word learning, appears linked with categorical induction ability in TD children, suggesting a common underlying skill and consistent developmental trajectory. Word learning and categorical induction appear uncoupled in children with ASD.
A distance sampling survey of the Critically Endangered Straw-headed BulbulPycnonotus zeylanicusin Singapore
Authors: CHIOK WEN XUAN , NG ELIZE Y. X. , TANG QIAN , LEE JESSICA G. H. , RHEINDT FRANK E.
Published: November 2020

The Straw-headed BulbulPycnonotus zeylanicusis one of South-East Asia’s most threatened songbirds due to relentless demand for the regional cage-bird trade. The species was recently uplisted from ‘Endangered’ to ‘Critically Endangered’ only two years after its previous uplisting. Intriguingly, populations in highly urbanised Singapore appear relatively secure. However, the last Singaporean density estimates, derived from traditional census methods, were obtained nearly two decades ago in 2001. A recent population estimate in 2016 was derived from the census work in 2001 coupled with relative abundance indices from population trends. We thus performed systematic field surveys using the distance sampling method, estimating 573 ± 185 individuals nation-wide, with a break-down of 217 ± 81 on the main island of Singapore and 356 ± 104 birds on the satellite of Pulau Ubin. Taken together, the total population estimate reported here comprises 22.9–57.3% of the global wild population, underscoring the importance of Singapore as a stronghold for the species. In spite of its apparently secure status in Singapore, the species remains susceptible to local and foreign trapping pressures. Based on our assessment, we propose a number of local and regional conservation measures to ensure the continued survival of populations in Singapore.
Culturable endophytic bacteria from Phelipanche ramosa (Orobanchaceae) seeds
Authors: Durlik Katarzyna , Żarnowiec Paulina , Piwowarczyk Renata , Kaca Wiesław
Published: November 2020

Endophytic microbiomes play a beneficial role in the development and protection of plants. However, seed-borne endophytic bacteria have not yet been fully explored. Investigation of parasitic plants, whose existence depends on yet poorly understood and complicated relationships with microorganisms and hosts, is particularly crucial. Endophytic bacteria promote seed conservation and facilitate seed germination in soil. Several root holoparasites from the Orobanchaceae family are the most aggressive broomrape species, often causing serious yield losses in important crops. Parasitic plants are characterized by the production of a large number of some of the smallest seeds in the world's flora, allowing them to stay viable in the soil for several dozen years. This study's aim was to isolate and characterize the seed endophyte and surface bacteria of the most aggressive and widespread broomrape weed, Phelipanche ramosa. We isolated two endophytic bacteria from within the seeds which are closely related to Brevibacterium frigoritolerans and Bacillus simplex described as soil bacteria, highly resistant to environmental conditions, and as plant growth-promoting rhizobacteria. Moreover, we isolated three strains from the surface of non-sterile seeds; all three isolates were related to the Bacillus cereus group.
Genetic diversity of Juglans sigillata Dode germplasm in Yunnan Province, China, as revealed by SSRs
Authors: Chen Shaoyu , Wu Tao , Xiao Liangjun , Ning Delu , Pan Li
Published: November 2020

Iron walnut, Juglans sigillata Dode, restricted to southwestern China, has its centre of distribution in Yunnan Province which has a varied climate, geography and rich plant diversity. Yunnan contains abundant J. sigillata germplasm. In this study, a provincial-scale set of walnut germplasm resources (14 populations comprising 1122 individuals) was evaluated for genetic diversity based on 20 simple sequence repeat (SSR) loci. The number of SSR alleles per locus ranged from 7 to 27, with an average of 17.55. Mean allelic richness and mean private allelic richness ranged from 3.40 to 4.62 and 0.11 to 0.36, with average of 3.93 and 0.30, respectively. Expected heterozygosity (He) varied from 0.26 to 0.78, with an average of 0.57. Polymorphism information content ranged from 0.22 to 0.79, with an average of 0.57. Genetic differentiation (FST) was 0.05, indicating that only 5% of total genetic variability was inter-populational, a finding supported by an analysis of molecular variance and STRUCTURE analysis. Relatively high gene flow (Nm = 6.70) was observed between populations. A unweighted pair-group method with arithmetic analysis classified the 14 populations into two major groups. Mantel testing uncovered a significant correlation between geographic distance and genetic distance (r = 0.33, P = 0.04). Overall, the research revealed a moderately high level of genetic diversity in the germplasm and low genetic differentiation among populations, which showed great potential for further development and exploitation of this resource.
River Co-governance and Co-management in Aotearoa New Zealand: Enabling Indigenous Ways of Knowing and Being
Authors: Fisher Karen , Parsons Meg
Published: November 2020

Legislation emerging from Treaty of Waitangi settlements provide Māori, the Indigenous people of Aotearoa New Zealand, with new opportunities to destabilize and decolonize the colonial knowledge, processes and practices that contribute towards negative material and metaphysical impacts on theirrohe[traditional lands and waters]. In this article we focus our attention on the Nga Wai o Maniapoto (Waipa River) Act 2012 and the Deed of Settlement signed between the Crown (the New Zealand government) and Ngāti Maniapoto (the tribal group with ancestral authority over the Waipā River) as an example of how the law in Aotearoa New Zealand is increasingly stretched beyond settler-colonial confines to embrace legal and ontological pluralism. We illustrate how this Act serves as the foundation upon which Ngāti Maniapoto are seeking to restore, manage, and enhance the health of their river. Such legislation, we argue, provides a far higher degree of recognition of Māori rights and interests both as an outcome of the settlement process and by strengthening provisions under the Resource Management Act 1991 regarding the role of Māori in resource management. We conclude by suggesting that co-governance and co-management arrangements hold great potential for transforming river management by recognizing and accommodating ontological and epistemological pluralism, which moves Aotearoa New Zealand closer to achieving sustainable and just river futures for all.