bluuebunny/crossref_metadata_2025 huggingface dataset:
Wirkmechanismen körperlicher Aktivität auf den Schlaf bei Patienten mit Depression: Ein Narratives Review
Authors: Brupbacher Gavin , Schneiders Anke , Schmidt-Trucksäss Arno , von Känel Roland , Straus Doris
Published: November 2022

Insomnie ist eines der Kardinalsymptome einer unipolaren Depression. Insomnie hat dabei einen negativen Einfluss auf den Krankheitsverlauf, ist eines der häufigsten Residualsymptome und ein Risikofaktor für ein Rezidiv. Im vorliegenden Überblick werden mögliche Wirkmechanismen von körperlichem Training auf den Schlaf bei Patienten mit Depression zusammengefasst. Die vorgestellten Mechanismen beruhen auf Daten aus In-vitro‑, Tier- und Humanstudien, welche die Effekte von Kraft‑, Ausdauer- und Mind-Body-Training untersuchen. Sowohl akutes Training als auch über mehrere Wochen regelmäßig absolviertes Training kann über verschiedene Signalwege positive Effekte auf den Schlaf bei Patienten mit Depression haben. Folgende Mechanismen sind dabei relevant: Zeitgebereffekte, Energiekonservierung, Regeration, Thermoregulation, psychophysiologische Effekte und „tissue–brain crosstalk“. Diese Befunde sind relevant, um die Therapie von nichtorganischen Schlafstörungen im Rahmen einer depressiven Episode besser zu verstehen, weiterzuentwickeln und auf individuelle Patienten anzupassen.
Energy Sovereignty: A Values-Based Conceptual Analysis
Authors: Timmermann Cristian , Noboa Eduardo
Published: November 2022

Achieving energy sovereignty is increasingly gaining prominence as a goal in energy politics. The aim of this paper is to provide a conceptual analysis of this principle from an ethics and social justice perspective. We rely on the literature on food sovereignty to identify through a comparative analysis the elements energy sovereignty will most likely demand and thereafter distinguish the unique constituencies of the energy sector. The idea of energy sovereignty embraces a series of values, among which we identified: (i) accessibility, to allow access to everyone, (ii) empowerment and recognition, to develop and sustain capabilities to collaboratively produce solution-oriented energy system knowledge and effectively participate in governance, (iii) stewardship and sustainability, to be able to design and manage decentralised renewable systems in view of protecting the environment, (iv) self-sufficiency, to reduce the negative shocks of exploitative business practises, (v) resilience, to maintain production capacities while withstanding socioeconomic, political, environmental and climatic shocks, (vi) peace, to establish production systems that do not involve hostile relations, (vii) transparency and self-determination, to establish democratic decision-making mechanisms that give a voice to previously underrepresented groups and limit corporate takeover (viii) gender-justice, by acknowledging the contributions of women and eliminate barriers to their empowerment. With a conceptual framework of energy sovereignty, we present a rationale that draws on the key values to be considered when formulating policy solutions for the energy sector.
Clothing motivation, online critical thinking, and the behavioural intention of clothing collocation: Mediation analysis on Chinese youth
Authors: Li Yingyan , Feng Xiangyuan
Published: November 2022

Recent years have witnessed a boom of fashion blogging sharing information about clothing and cosmetics on diverse social media platforms. Constant exposure to fashion-related digital information heavily impacts the conception and behaviours of Chinese youth. Compared to the substantial studies on the impact of social media, scarce research has been conducted on how youth’s cognitive processing of fashion-related digital information interacts with motivational factors to determine the subsequent behaviours. This study made an initial attempt to address this issue by exploring the successive associations between clothing motivation (amotivation, controlled, and autonomous motivation), online critical thinking (for information credibility, objectivity, and relevance), and the subsequent behavioural intention. A total of 1997 Chinese youth with diverse educational backgrounds voluntarily participated in the study. Results confirmed the direct links between clothing motivation and the behavioural intention, and these links were mediated by different online critical thinking practices. This study provides new insights for both practitioners and scholars in the fields of education, psychology, social media, and marketing.
Interactions Between Teachers and Students with Autism Spectrum Disorder in Mainstream Secondary Education: Fundamental, yet Under-Researched
Authors: Esqueda Villegas Fernanda , van der Steen Steffie , Minnaert Alexander
Published: November 2022

This study aimed to identify which aspects of teacher-student interactions contribute to a successful inclusion of students with autism spectrum disorder (ASD) in mainstream secondary classrooms. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were followed. Eight studies fulfilled our criteria, and we identified teacher-related and student-related themes. Most of the included studies did not focus on interactions between teachers and students with ASD, but on requirements that could influence these interactions. Teachers often seemed to infer the needs of students with ASD during their interactions, which, as we illustrate, may not always be in line with their actual needs. We discuss the implications of this gap in the literature and how to bridge this gap.
Radiofrequency echographic multi-spectrometry and DXA for the evaluation of bone mineral density in a peritoneal dialysis setting
Authors: Fassio Angelo , Andreola Stefano , Gatti Davide , Bianco Beatrice , Gatti Matteo , Gambaro Giovanni , Rossini Maurizio , Viapiana Ombretta , Negrelli Riccardo , Adami Giovanni
Published: November 2022

Background

The aim of this real-life cross-sectional explorative study was to compare radiofrequency echographic multi-spectrometry (REMS) with dual-energy X-rays absorptiometry (DXA) in the BMD assessment of patients receiving peritoneal dialysis (PD). Furthermore, we investigated the relationship between lumbar aortic calcifications (AOCs) and the DXA lumbar measurements.

Methods

Consecutive patients referring to the PD clinic of our hospital were included. Lumbar spine and femur scans were acquired with both techniques (including lumbar laterolateral DXA scans). The risk assessment of two fracture risk algorithms (FRAX® and DeFRA®) were compared. Cohen’s k coefficients were used to assess the inter-technique agreement in the classification of patients as osteoporotic. Lumbar AOCs were estimated semi-quantitatively on laterolateral DXA scans.

Results

41 patients were enrolled. No significant differences were documented between the BMD T-scores measured through DXA or REMS at the femur. At the lumbar spine, the DXA anteroposterior mean T-score (− 0.49 ± 1.98) was significantly higher than both the laterolateral DXA (− 1.66 ± 0.99) and the REMS (− 2.00 ± 1.94) measurements (p < 0.01 vs both). No significant differences were found between the DXA and REMS fracture risk estimates with both algorithms. The inter-technique Cohen’s k coefficient (for the worst T-score, any site) was 0.421, p < 0.001. The discrepancy between the DXA laterolateral and anteroposterior lumbar T-score was positively associated with the AOCs extent and severity (r = 0.402, p < 0.01).

Conclusions

Our data showed a promising agreement, in a real-life PD setting, between DXA and REMS BMD assessment and in the consequent fracture risk estimation and confirm the AOCs interference on the diagnostic accuracy of lumbar DXA.
Inflammatory bowel disease addressed by Caco-2 and monocyte-derived macrophages: an opportunity for an in vitro drug screening assay
Authors: Schnur Sabrina , Wahl Vanessa , Metz Julia K. , Gillmann Jessica , Hans Fabian , Rotermund Katharina , Zäh Ralf-Kilian , Brück Dietmar A. , Schneider Marc , Hittinger Marius
Published: November 2022

Inflammatory bowel disease (IBD) is a widespread disease, affecting a growing demographic. The treatment of chronic inflammation located in the GI-tract is dependent on the severity; therefore, the IBD treatment pyramid is commonly applied. Animal experimentation plays a key role for novel IBD drug development; nevertheless, it is ethically questionable and limited in its throughput. Reliable and valid in vitro assays offer the opportunity to overcome these limitations.

We combined Caco-2 with monocyte-derived macrophages and exposed them to known drugs, targeting an in vitro-in vivo correlation (IVIVC) with a focus on the severity level and its related drug candidate. This co-culture assay addresses namely the intestinal barrier and the immune response in IBD. The drug efficacy was analyzed by an LPS-inflammation of the co-culture and drug exposure according to the IBD treatment pyramid. Efficacy was defined as the range between LPS control (0%) and untreated co-culture (100%) independent of the investigated read-out (TEER, Papp, cytokine release: IL-6, IL-8, IL-10, TNF-α).

The release of IL-6, IL-8, and TNF-α was identified as an appropriate readout for a fast drug screening (“yes–no response”). TEER showed a remarkable IVIVC correlation to the human treatment pyramid (5-ASA, Prednisolone, 6-mercaptopurine, and infliximab) with an R2 of 0.68. Similar to the description of an adverse outcome pathway (AOP) framework, we advocate establishing an “Efficacy Outcome Pathways (EOPs)” framework for drug efficacy assays. The in vitro assay offers an easy and scalable method for IBD drug screening with a focus on human data, which requires further validation.
Merleau-Ponty's Phenomenology of Perception
Authors: Mooney Timothy D.
Published: November 2022

This is an advanced introduction to and original interpretation of Merleau-Ponty's greatest work, Phenomenology of Perception. Timothy Mooney provides a clear and compelling exposition of the theory of our projective being in the world, and demonstrates as never before the centrality of the body schema in the theory. Thanks to the schema's motor intentionality our bodies inhabit and appropriate space: our postures and perceptual fields are organised schematically when we move to realise our projects. Thus our lived bodies are ineliminably expressive in being both animated and outcome oriented through-and-through. Mooney also analyses the place of the work in the modern philosophical world, showing what Merleau-Ponty takes up from the Kantian and Phenomenological traditions and what he contributes to each. Casting a fresh light on his magnum opus, this book is essential reading for all those interested in the philosophy and phenomenology of the body.
A computational examination of large-scale pool fires: variations in crosswind velocity and pool shape
Authors: Scott Sarah N. , Domino Stefan P.
Published: November 2022

A high-fidelity large-eddy simulation and unsteady flamelet combustion model construct is deployed to numerically investigate the effects of crosswind magnitude and pool fire shape on large-scale pool fire attributes. These include general flame dynamics, flame shape and radiative flux magnitude in and around the fire. Three pool fire shapes at a nominal length scale of 10 m are subjected to four crosswind magnitudes between 0 and 20 m s

$^{-1}$

. The pool shapes studied are circular, square and rectangular. The study includes the sensitivity of parameters to mesh and time step refinement. Results demonstrate that the rectangular shape, under crosswind, has low-levels of vertical velocity induction, resulting in a plume that is closer to the ground. In the quiescent regime, under-resolved meshes provide a higher radiative heat flux prediction compared with the most refined mesh. However, as crosswind increases, low mesh resolutions underpredicted radiative flux. This is due to the coarse mesh resolution not capturing small-scale vortical features that increased mixing and combustion efficiency. A transition of peak radiative flux with respect to crosswind occurs from the leeward- to windward-side of the pool, while sharp pool features result in larger radiative heat fluxes concentrated in regions of high scalar dissipation rate.
‘Climate Change isn't Optional’: Climate Change in the Core Law Curriculum
Authors: Bouwer Kim , John Evan , Luke Oliver , Rozhan Amanda
Published: November 2022

This paper makes a case for the integration of compulsory climate change topics across the core law curriculum. It argues that the most persuasive rationale for this is based in climate legal obligations and institutions, and a clear-eyed perception of climate risk, rather than the sustainability agenda. To this end, the paper outlines efforts taken to ‘mainstream’ climate change and environmental law education in a core course of the LLB degree – land law. An empirical study sought to evaluate the students’ engagement with these materials, and their broader views concerning climate change and their legal education. The paper critically evaluates the course and the results of the empirical study. It concludes that students want to be, and should be, taught climate law and the climate context of law as part of their prescribed learning throughout the core curriculum, rather than as optional or elective content.
Local fluxes in magnetohydrodynamic turbulence
Authors: Alexakis Alexandros , Chibbaro Sergio
Published: November 2022

Using highly resolved direct numerical simulations we examine the statistical properties of the local energy flux rate

$\varPi _\ell (x)$

towards small scales for three isotropic turbulent magnetohydrodynamic flows, which differ in strength and structure of the magnetic field. We analyse the cascade process in both kinetic and magnetic energy, disentangling the different flux contributions to the overall energy dynamics. The results show that the probability distribution of the local energy flux develops long tails related to extreme events, similar to the hydrodynamic case. The different terms of the energy flux display different properties and show sensitivity to the type of the flow examined. We further examine the joint probability density function between the local energy flux and the gradients of the involved fields. The results point out a correlation with the magnetic field gradients, showing, however, a dispersion much stronger than what is observed in hydrodynamic flows. Finally, it is also shown that the local energy flux shows some dependence on the local amplitude of the magnetic field. The present results have implications for subgrid-scale models, which we discuss.
New record of smalltooth sand tiger Odontaspis ferox (Risso, 1810) in the Mediterranean
Authors: Soldo Alen , Bakiu Rigers , Hysolakoj Nexhip
Published: November 2022

One shark was landed at the Naval Base Pasha Liman, Bay of Vlore, Albania, the Adriatic Sea. Photographic records only enabled the specimen to be placed in family Odontaspididae or Carchariidae. Later examination of the preserved head, dry jaw and dentition identified the specimen as Odontaspis ferox. This is a rare record and the northernmost Mediterranean observation of this species, and the first Adriatic record for several decades.
Prosecuting rap: what does the case law tell us?
Authors: Owusu-Bempah Abenaa
Published: November 2022

This article explores the admissibility and use of rap music as evidence in English criminal trials. It presents findings from an analysis of over 30 appeal cases. As well as unpacking the link between rap, race and gangs that is prevalent in these cases, the article challenges the categorisation of rap as ‘bad character evidence’, and critiques the way in which questions of relevance and prejudicial effect have been addressed by the courts. In particular, when making admissibility decisions, the courts appear to give little consideration to the cultural context, artistic conventions or social influences within the rap music genre, or the racialised nature of rap evidence. It is argued that, if rap is to be admissible evidence, a much more rigorous and informed approach is required.
Language teaching and learning in Ireland: 2012–2021
Authors: Batardière Marie-Thérèse , Berthaud Sarah , Ćatibušić Bronagh , Flynn Colin J.
Published: November 2022

The language teaching landscape in Ireland has changed considerably over the last 30 years as a result of substantial and sustained inward migration into the country during this period. These social and demographic developments have added to the country's already bilingual context and created a much more varied multilingual landscape than had existed in previous decades. They have also impacted various aspects of language teaching policy, provision and methods for both indigenous and foreign languages. This article reviews research on language teaching and learning in Ireland published during the period 2012–2021. We discuss relevant work disseminated primarily in peer-reviewed journals (national and international), as well as in books, commissioned reports and chapters in edited volumes. The research and policy documents presented concern the teaching and learning of Irish, English and Modern Foreign Languages as second and/or additional languages across all levels of education. They address language teacher training contexts as well. We believe that this review of research demonstrates the extent to which recent inquiries in these domains have advanced knowledge and practice in the Irish context, and have also informed the international research community more generally.
Brownian bridge expansions for Lévy area approximations and particular values of the Riemann zeta function
Authors: Foster James , Habermann Karen
Published: November 2022

We study approximations for the Lévy area of Brownian motion which are based on the Fourier series expansion and a polynomial expansion of the associated Brownian bridge. Comparing the asymptotic convergence rates of the Lévy area approximations, we see that the approximation resulting from the polynomial expansion of the Brownian bridge is more accurate than the Kloeden–Platen–Wright approximation, whilst still only using independent normal random vectors. We then link the asymptotic convergence rates of these approximations to the limiting fluctuations for the corresponding series expansions of the Brownian bridge. Moreover, and of interest in its own right, the analysis we use to identify the fluctuation processes for the Karhunen–Loève and Fourier series expansions of the Brownian bridge is extended to give a stand-alone derivation of the values of the Riemann zeta function at even positive integers.
The Latent Potential of Cumulative Effects Concepts in National and International Environmental Impact Assessment Regimes
Authors: Nelson Rebecca , Shirley L.M.
Published: November 2022

Most modern-day environmental issues are caused by the complex aggregation and interaction of numerous actions contributing to large-scale problems, from biodiversity loss to climate change. Environmental impact assessments (EIAs) consider how projects contribute to these cumulative environmental problems. This article firstly evaluates the theoretical importance of cumulative effects concepts for EIA. It reveals their potential to spotlight values embedded in decision making and to illuminate, as a lighthouse would, types of harm from broad-ranging, typically unregulated, activities. A large-scale global survey of national EIA laws and multilateral environmental agreements then shows that cumulative effects concepts are legally relevant for most national EIA frameworks. This prevalence suggests that better implementation of cumulative effects provisions may help EIA law to deliver more significant benefits than previously appreciated. Evaluating a sample of EIA provisions shows that cumulative effects concepts can contribute to different stages of an EIA, but that using these concepts across all EIA stages would maximize their potential to achieve the theoretical benefits identified. From theoretical and practical legal perspectives, cumulative effects concepts have significant latent potential – perhaps transformational potential – to address cumulative environmental change through EIA regimes at national and international levels. However, without better implementation, the latent potential of these laws to address cumulative environmental problems is likely to remain unrealized. By shedding light on the extent of national and international legal frameworks that adopt cumulative effects concepts, and their differences, this article highlights the significant learning potential between legal regimes to aid improved implementation.
Response to Comment Paper by Dr. Maxim A. Yurkin for 2021 JGR Paper “Evaluation of Higher‐Order Quadrature Schemes in Improving Computational Efficiency for Orientation‐Averaged Single‐Scattering Properties of Nonspherical Ice Particles”
Authors: Fenni Ines , Kuo Kwo‐Sen , Haynes Mark S. , Haddad Ziad S. , Roussel Hélène
Published: November 2022

We thank Dr. Yurkin for his considered and constructive critique of our paper. We respond to his insightful comments below and hope that this discussion motivates further communication and cooperation and benefits to the scattering by small particles community.
Composite Effects of ENSO and EASM on Summer Ozone Pollution in Two Regions of China
Authors: Lu Shuhua , Gong Sunling , Chen Jianmin , He Jianjun , Lin Yanfen , Li Xin , Zhang Lei , Mo Jingyue , Zhao Shuo , You Yan , Pan Weijun
Published: November 2022

Combining the 3‐D reanalysis with the surface observational O3 data, this study investigated the composite effects of the El Niño‐Southern Oscillation (ENSO) and East Asian summer monsoon (EASM) on summer O3 pollution in two regions of China, that is, the Beijing‐Tianjin‐Hebei (BTH) and the Yangtze River Delta (YRD). The results show that the El Niño has significantly enhanced the near surface O3 pollution in the BTH, but has little effect on surface O3 in the YRD. On the contrary, the La Niña has mainly reduced the surface O3 pollution in the YRD with little effect in the BTH. When the El Niño and a strong EASM occurred at the same time, the effect on O3 was more significant than that by the El Niño event alone due to the extra intensification of the vertical transport of O3 with about 10–30 μg/m3 from stratosphere and the worsening of the horizontal diffusion conditions (easterly wind anomalies) in the BTH. The La Niña with a weak EASM played a dominant role in the reduction of O3 pollution in the YRD by improving the meteorological conditions (especially in total cloud cover) and horizontal diffusion conditions (westerly wind anomalies). These composite effects were reflected in the trends of summer surface O3 in the BTH and the YRD, and became the crucial contributors to the abnormal changes of summer surface O3 in some years when the ENSO/EASM happened.
Dynamic Downscaling the South Asian Summer Monsoon From a Global Reanalysis Using a Regional Coupled Ocean‐Atmosphere Model
Authors: Misra Vasubandhu , Jayasankar C. B. , Mishra A. K. , Mitra A. , Murugavel P.
Published: November 2022

In this study, we present the results of a regional model (regional spectral model‐regional ocean model [(RSM‐ROMS]) simulation of the South Asian Summer Monsoon (SASM). The RSM‐ROMS integration is carried out at 20 km grid spacing over a period of 25 years (1986–2010). The simulation is forced by global atmospheric and oceanic reanalysis. The RSM‐ROMS simulation shows a realistic alignment of the simulated rainfall along the orographic features of the domain. Furthermore, the RSM‐ROMS simulates the observed feature of convection over continental SASM region being more vigorous with dominance of mixed warm and cold phase hydrometeors in contrast to the dominance of the warm rain process in the neighboring tropical oceans. Similarly, the upper ocean features of contrasting mixed layer and thermocline depths between the northern and equatorial Indian Ocean are also simulated in the RSM‐ROMS. Intra‐Seasonal Oscillation (ISO) of the SASM at 10–20 and 20–70 days are also simulated in the RSM‐ROMS with many of its features verifying with observations. For example, the 20–70 days ISO are of higher amplitude and its meridional propagation is slower in Bay of Bengal compared to that over Arabian Sea. Additionally, RSM‐ROMS shows 12.3 Monsoon Low Pressure Systems (LPSs) per season that is comparable to 14.6 per season from observations. Furthermore, the observed intraseasonal contrasts of LPS between the wet and dry spells of ISO is also reproduced in the RSM‐ROMS.
Experimentally unsupervised deconvolution for light-sheet microscopy with propagation-invariant beams
Authors: Wijesinghe Philip , Corsetti Stella , Chow Darren J. X. , Sakata Shuzo , Dunning Kylie R. , Dholakia Kishan
Published: November 2022

Deconvolution is a challenging inverse problem, particularly in techniques that employ complex engineered point-spread functions, such as microscopy with propagation-invariant beams. Here, we present a deep-learning method for deconvolution that, in lieu of end-to-end training with ground truths, is trained using known physics of the imaging system. Specifically, we train a generative adversarial network with images generated with the known point-spread function of the system, and combine this with unpaired experimental data that preserve perceptual content. Our method rapidly and robustly deconvolves and super-resolves microscopy images, demonstrating a two-fold improvement in image contrast to conventional deconvolution methods. In contrast to common end-to-end networks that often require 1000–10,000s paired images, our method is experimentally unsupervised and can be trained solely on a few hundred regions of interest. We demonstrate its performance on light-sheet microscopy with propagation-invariant Airy beams in oocytes, preimplantation embryos and excised brain tissue, as well as illustrate its utility for Bessel-beam LSM. This method aims to democratise learned methods for deconvolution, as it does not require data acquisition outwith the conventional imaging protocol.
Optically-generated focused ultrasound for noninvasive brain stimulation with ultrahigh precision
Authors: Li Yueming , Jiang Ying , Lan Lu , Ge Xiaowei , Cheng Ran , Zhan Yuewei , Chen Guo , Shi Linli , Wang Runyu , Zheng Nan , Yang Chen , Cheng Ji-Xin
Published: November 2022

High precision neuromodulation is a powerful tool to decipher neurocircuits and treat neurological diseases. Current non-invasive neuromodulation methods offer limited precision at the millimeter level. Here, we report optically-generated focused ultrasound (OFUS) for non-invasive brain stimulation with ultrahigh precision. OFUS is generated by a soft optoacoustic pad (SOAP) fabricated through embedding candle soot nanoparticles in a curved polydimethylsiloxane film. SOAP generates a transcranial ultrasound focus at 15 MHz with an ultrahigh lateral resolution of 83 µm, which is two orders of magnitude smaller than that of conventional transcranial-focused ultrasound (tFUS). Here, we show effective OFUS neurostimulation in vitro with a single ultrasound cycle. We demonstrate submillimeter transcranial stimulation of the mouse motor cortex in vivo. An acoustic energy of 0.6 mJ/cm2, four orders of magnitude less than that of tFUS, is sufficient for successful OFUS neurostimulation. OFUS offers new capabilities for neuroscience studies and disease treatments by delivering a focus with ultrahigh precision non-invasively.
Reduced expression of FRG1 facilitates breast cancer progression via GM-CSF/MEK-ERK axis by abating FRG1 mediated transcriptional repression of GM-CSF
Authors: Mukherjee Bratati , Tiwari Ankit , Palo Ananya , Pattnaik Niharika , Samantara Subrat , Dixit Manjusha
Published: November 2022

Multiple molecular subtypes and distinct clinical outcomes in breast cancer, necessitate specific therapy. Moreover, despite the improvements in breast cancer therapy, it remains the fifth cause of cancer-related deaths, indicating the involvement of unknown genes. To identify novel contributors and molecular subtype independent therapeutic options, we report reduced expression of FRG1 in breast cancer patients, which regulates GM-CSF expression via direct binding to its promoter. Reduction in FRG1 expression enhanced EMT and increased cell proliferation, migration, and invasion, in breast cancer cell lines. Loss of FRG1 increased GM-CSF levels which activated MEK/ERK axis and prevented apoptosis by inhibiting p53 in an ERK-dependent manner. FRG1 depletion in the mouse model increased tumor volume, phospho-ERK, and EMT marker levels. The therapeutic potential of anti-GM-CSF therapy was evident by reduced tumor size, when tumors with decreased FRG1 were treated with anti-GM-CSF mAb. We found an inverse expression pattern of FRG1 and phospho-ERK levels in breast cancer patient tissues, corroborating the in vitro and mouse model-based findings. Our findings first time elucidate the role of FRG1 as a metastatic suppressor of breast cancer by regulating the GM-CSF/MEK-ERK axis.
Vexed mutations promote degeneration of dopaminergic neurons through excessive activation of the innate immune response
Authors: Davis Jacinta , Kolaski Elizabeth , Babcock Daniel T.
Published: November 2022

The hallmark of Parkinson’s disease (PD) is the loss of dopaminergic (DA) neurons in the brain. However, little is known about why DA neurons are selectively vulnerable to PD. We previously completed a screen identifying genes associated with the progressive degeneration of DA neurons. Here we describe the role of a previously uncharacterized gene, CG42339, in the loss of DA neurons using Drosophila Melanogaster. CG42339 mutants display a progressive loss of DA neurons and locomotor dysfunction, along with an accumulation of advanced glycation end products (AGEs) in the brain. Based on this phenotype, we refer to CG42339 as vexed. We demonstrate that vexed is specifically required within cortex glia to maintain neuronal viability. Loss of vexed function results in excessive activation of the innate immune response in the brain, leading to loss of DA neurons. We show that activation of the innate immune response leads to increased nitric oxide signaling and accumulation of AGEs, which ultimately result in neurodegeneration. These results provide further insight into the relationship between the role of the immune response in the central nervous system and how this impacts neuronal viability.
Mountain- and brown hare genetic polymorphisms to survey local adaptations and conservation status of the heath hare (Lepus timidus sylvaticus, Nilsson 1831)
Authors: Michell Craig T. , Pohjoismäki Jaakko L. O. , Spong Göran , Thulin Carl-Gustaf
Published: November 2022

We provide the first whole genome sequences from three specimens of the mountain hare subspecies the heath hare (Lepus timidus sylvaticus), along with samples from two mountain hares (Lepus timidus timidus) and two brown hares (Lepus europaeus) from Sweden. The heath hare has a unique grey winter pelage as compared to other mountain hares (white) and brown hares (mostly brown), and face regional extinction, likely due to competitive exclusion from the non-native brown hare. Whole genome resequencing from the seven hare specimens were mapped to the Lepus timidus pseudoreference genome and used for detection of 11,363,883 polymorphic nucleotide positions. The data presented here could be useful for addressing local adaptations and conservation status of mountain hares and brown hares in Sweden, including unique subspecies.
Chromosome-level genome assembly of Nibea coibor using PacBio HiFi reads and Hi-C technologies
Authors: Yekefenhazi Dinaer , He Qiwei , Wang Xiaopeng , Han Wei , Song Chaowei , Li Wanbo
Published: November 2022

Nibea coibor belongs to Sciaenidae and is distributed in the South China Sea, East China Sea, India and the Philippines. In this study, we sequenced the DNA of a male Nibea coibor using PacBio long-read sequencing and generated chromatin interaction data. The genome size of Nibea coibor was estimated to be 611.85~633.88 Mb based on k-mer counts generated with Jellyfish. PacBio sequencing produced 29.26 Gb of HiFi reads, and Hifiasm was used to assemble a 627.60 Mb genome with a contig N50 of 10.66 Mb. We further found the canonical telomeric repeats “TTAGGG” to be present at the telomeres of all 24 chromosomes. The completeness of the assembly was estimated to be 98.9% and 97.8% using BUSCO and Merqury, respectively. Using the combination of ab initio prediction, protein homology and RNAseq annotation, we identified a total of 21,433 protein-coding genes. Phylogenetic analyses showed that Nibea coibor and Nibea albiflora are closely related. The results provide an important basis for research on the genetic breeding and genome evolution of Nibea coibor.
High-dose X-ray radiation induced MgO degradation and breakdown in spin transfer torque magnetic tunnel junctions
Authors: He Qi , Shi Hui , Wang Yinquan , Cao Lichao , Gu Xiang , Wu Jianwei , Hong Genshen , Li Minghua
Published: November 2022

Magnetic tunnel junction (MTJ) with magnesium oxide (MgO) tunnel barrier is the core element of spin transfer torque-based magnetic random access memory. For the application in the space environment, the total ionizing dose radiation effects on MTJs need to be evaluated. In this work, the MTJs were exposed to X-ray radiation with different doses of up to 10 Mrad(Si). Measurements of current induced magnetization switching (CIMS) behavior of these MTJs were performed before and after radiation. The results show negligible changes in the tunneling magnetoresistance and current switching properties after 8 Mrad(Si) X-ray radiation. However, with a total dose of 9 Mrad(Si), a significant reduction in junction resistance of a fairly large number of MTJs was observed, which showed characteristics of MTJ breakdown. Moreover, in this study, all experimental MTJs became functionally disabled due to MgO breakdown under 10 Mrad(Si) X-ray radiation. The CoFeB/MgO/CoFeB interface microstructure was observed using X-ray photoelectron spectroscopy and high-resolution transmission electron microscopy (HRTEM). Interfacial structural results indicate that the MgO degradation and breakdown behavior caused by X-ray ionizing radiation can give rise to radiation-induced oxygen vacancies across the tunnel barrier oxide layer.
Stability and degradation in triple cation and methyl ammonium lead iodide perovskite solar cells mediated via Au and Ag electrodes
Authors: Kranthiraja Kakaraparthi , Parashar Mritunjaya , Mehta Ravindra K. , Aryal Sujan , Temsal Mahdi , Kaul Anupama B.
Published: November 2022

Perovskite solar cells (PSCs), particularly based on the methyl ammonium lead iodide (MAPbI3) formulation, have been of intense interest for the past decade within the photovoltaics (PV) community, given the stupendous rise in power conversion efficiencies (PCEs) attributed to these perovskite formulations, where PCEs have exceeded 25%. However, their long-term stability under operational conditions and environmental storage are still prime challenges to be overcome towards their commercialization. Although studies on the intrinsic perovskite absorber stability have been conducted previously, there are no clear mechanisms for the interaction of electrode-induced absorber degradation pathways, which is the focus of this study. In this report, we have conducted a comprehensive analysis on the impact of the electrode collector layer, specifically Ag and Au, on the degradation mechanism associated with the MAPbI3and a triple cation absorber, Cs0.05FA0.79MA0.16PbI2.45Br0.55. Notably, Au-based PSCs for both absorbers in an n-i-p architecture showed superior PCE over Ag-based PSCs, where the optimized PCE of MAPbI3and triple cation-based PSCs was 15.39% and 18.21%, respectively. On the other hand, optimized PCE of MAPbI3and triple cation-based PSCs with Ag electrodes was 3.02% and 16.44%, respectively. In addition, the Ag-based PSCs showed a rapid decrease in PCE over Au-based PSCs through operational stability measurements. We hypothesize the mechanism of degradation, arising from the Ag interaction with the absorber through the formation of AgI in the PSCs, leads to corrosion of the perovskite absorber, as opposed to the benign AuI when Au electrodes are used in the solar cell stack. Additionally, novel use of photoluminescence spectroscopy (PL) here, allowed us to access key features of the perovskite absorber in situ, while it was in contact with the various layers within the n-i-p solar cell stack. A quenching in the PL peak in the case of Ag-contacted MAPbI3provided direct evidence of the Ag corrupting the optical properties of the absorber through the formation of AgI which our X-ray diffraction (XRD) results confirmed. This was supported by the fact that an emission peak was still present in the triple cation Ag-device. For the Au-contacted MAPbI3the presence of a well-defined PL peak, though attenuated from the triple cation Au-device, suggested the AuI does not quell the emission spectrum for either the triple cation or the MAPbI3absorber. The findings should aid in the understanding and design of new electrode materials with PSCs, which will help accelerate their introduction into the commercial sector in the future.
Colorimetric sensor arrays for the differentiation of baijiu based on amino-acid-modified gold nanoparticles
Authors: Jia Junjie , Zhang Suyi , Ma Long , Zheng Lei , Yu Songbai , Shen Caihong , Fu Haiyan , Wang Songtao , She Yuanbin
Published: November 2022

It is of great significance for quality control to realize the discrimination for baijiu from different brands and origins. Strong-aroma-type baijiu (SAB), one of the most important Chinese aroma-type baijiu, exhibits the largest variety and market share. In this study, we proposed colorimetric sensor arrays based on gold nanoparticles (AuNPs) modified with different amino acids (AAs) to recognize the organic acids, and further distinguish different SABs. Three representative AAs, namely methionine (Met), tryptophan (Trp), and histidine (His), were selected to modify the AuNPs surface. The investigation of the effect of the main ingredients of SAB on AA@AuNPs aggregation confirmed that this aggregation mainly resulted from organic acids. Moreover, this aggregation was successfully used for differentiating 11 organic acids. Different pH conditions can not only cause changes of the content of organic acids in baijiu, but also disrupt the balance among flavor substances of baijiu to some extent. Consequently, the AA@AuNPs arrays under two pH conditions have been successfully applied to distinguish 14 kinds of SABs from different brands and origins. The proposed colorimetric sensor method is simple, rapid, and visualized and provides a potential application prospect for the quality control of baijiu and other alcoholic beverages.
Sampling from four geographically divergent young female populations demonstrates forensic geolocation potential in microbiomes
Authors: Clarke Thomas , Brinkac Lauren , Greco Chris , Alleyne Angela T. , Carrasco Patricio , Inostroza Carolina , Tau Tiiseto , Wisitrasameewong Wichaya , Torralba Manolito G. , Nelson Karen , Singh Harinder
Published: November 2022

Studies of human microbiomes using new sequencing techniques have increasingly demonstrated that their ecologies are partly determined by the lifestyle and habits of individuals. As such, significant forensic information could be obtained from high throughput sequencing of the human microbiome. This approach, combined with multiple analytical techniques demonstrates that bacterial DNA can be used to uniquely identify an individual and to provide information about their life and behavioral patterns. However, the transformation of these findings into actionable forensic information, including the geolocation of the samples, remains limited by incomplete understanding of the effects of confounding factors and the paucity of diverse sequences. We obtained 16S rRNA sequences of stool and oral microbiomes collected from 206 young and healthy females from four globally diverse populations, in addition to supporting metadata, including dietary and medical information. Analysis of these microbiomes revealed detectable geolocation signals between the populations, even for populations living within the same city. Accounting for other lifestyle variables, such as diet and smoking, lessened but does not remove the geolocation signal.
Evidence for the coupling of refill liquids content and new particle formation in electronic cigarette vapors
Authors: Dada Oluwabunmi , Castillo Karina , Hogan Miranda , Chalbot Marie-Cecile G. , Kavouras Ilias G.
Published: November 2022

The size and chemical content of particles in electronic cigarette vapors (e-vapors) dictate their fate in the human body. Understanding how particles in e-vapors are formed and their size is critical to identifying and mitigating the adverse consequences of vaping. Thermal decomposition and reactions of the refill liquid (e-liquid) components play a key role in new particles formation. Here we report the evolution of particle number concentration in e-vapors over time for variable mixtures of refill e-liquids and operating conditions. Particle with aerodynamic diameter < 300 nm accounted for up to 17% (or 780 μg/m3) of e-vapors particles. Two events of increasing particle number concentration were observed, 2–3 s after puff completion and a second 4–5 s later. The intensity of each event varied by the abundance of propylene glycol, glycerol, and flavorings in e-liquids. Propylene glycol and glycerol were associated with the first event. Flavorings containing aromatic and aliphatic unsaturated functional groups were strongly associated with the second event and to a lesser extent with the first one. The results indicate that particles in e-vapors may be formed through the heteromolecular condensation of propylene glycol, glycerol, and flavorings, including both parent chemicals and/or their thermal decomposition products.
Mental health in pregnant individuals during the COVID-19 pandemic based on a Swiss online survey
Authors: Favre Guillaume , Kunz Cléa , Schwank Simone , Chung Ho-Fung , Radan Anda Petronela , Raio Luigi , Fluri Mihaela , Winterfeld Ursula , Baud David , Pomar Léo
Published: November 2022

The aim of our study was to evaluate the mental health of pregnant individuals during the early COVID-19 pandemic and the potential factors associated. A Swiss online survey was proposed to individuals who gave birth during the pandemic period from March 2020. The Edinburgh Postnatal Depression Scale (EPDS), Generalized Anxiety Disorder 7 questions (GAD-7), and Impact Event Scale-Revised (IES-R) were evaluated and used to defined mental health impairment as a composite outcome. From October, 2020 to February, 2021, 736 participants responded. The anxiety GAD-7 score was moderate in 9.6% and severe in 2.0%. The EPDS was moderate in 21.5% and severe in 32.9%. The IES-R was moderate in 10.3% and severe in 3.9%. Mental health impairment was reported in 37.0%. The association between the risk of mental health impairment and foreign nationality was significant (OR = 1.48; 95%CI [1.06–2.05]) as well as fetal and pregnancy worries because of coronavirus (OR = 1.46; 95% CI [1.08–1.98]) and 1.65; 95% CI [1.22–2.24]). Adjusted ORs were significant for foreign nationality (aOR = 1.51; 95%CI [1.07–2.13]) and pregnancy worries because of coronavirus (aOR = 1.62; 95%CI [1.10–2.40]). Pregnant people and especially foreign national have a high risk of mental health impairment during the pandemic.
Effect of crucible wall roughness on the laminar/turbulent flow transition of the Ga75In25 alloy stirred by a rotating magnetic field
Authors: Roósz András , Rónaföldi Arnold , Svéda Mária , Veres Zsolt
Published: November 2022

The critical magnetic induction (Bcr) values of a melt flow produced by a rotating magnetic field (RMF), remaining laminar or turbulent, are essential in different solidification processes. In an earlier paper (Metall Res Technol 100: 1043–1061, 2003), we showed that Bcr depends on the crucible radius (R) and frequency of the magnetic field (f). The effect of wall roughness (WR) on Bcr was investigated in this study. Using ten different wall materials, we determined the angular frequency (ω) and Reynolds number (Re) as a function of the magnetic induction (B) and f using two different measuring methods (pressure compensation method, PCM; height measuring method, HMM). The experiments were performed at room temperature; therefore, the Ga75wt%In25wt% alloy was chosen for the experiments. Based on the measured and calculated results, a simple relationship was determined between Bcr and Re*, f, R, and WR, where the constants K1, K2, K3, and K4 depended on the physical properties of the melt and wall material:

$$Bcr\left({Re}^{*},f,R,WR\right)=\frac{{Re}^{*}}{{R}^{2}}({K}_{1} {f}^{-K2}+{K}_{3} {f}^{-K4} WR)$$

B
c
r

Re

∗

,
f
,
R
,
W
R

=

Re

∗

R

2

(

K
1

f

-
K
2

+

K
3

f

-
K
4

W
R
)
Experimental study on freeze–thaw damage characteristics of coal samples of different moisture contents in liquid nitrogen
Authors: Wang Xiaoqi , Qi Xiaohan , Ma Heng , Gao Ke , Li Shengnan
Published: November 2022

In this study, the surface crack-propagation law and pore damage characteristics of coal samples of different water contents after they undergo leaching in liquid nitrogen are investigated using a 4 K scientific-research camera, HC-U7 non-metal ultrasonic detector, nuclear magnetic resonance testing technology, and self-made multi-functional three axial fluid–solid coupling test system. Experimental investigations are conducted on coal samples of different water contents before and after they undergo liquid-nitrogen freezing and thawing in order to determine the propagation law of surface fissures, the development law of internal micro-fissures, the development process of internal pores, the change law of the pore-size distribution, and the law of coal-sample deformation and gas seepage during the stress process. The test results show that, with the increase in water content in the liquid-nitrogen leaching process, the frost heave force on the coal surface increases, and the greater the increase ratio of the coal porosity, the faster is the development of micro-cracks and pores. Under the action of liquid nitrogen, the number of micro-pores, meso-pores, and macro-pores in the coal sample increased, and with the formation of new cracks and the connection of the original cracks, liquid-nitrogen freezing and thawing can promote the development of the pore structure in the coal body. The permeability changes of coal samples of different water contents during unloading failure exhibit obvious stage characteristics. The above results demonstrate that the moisture content of coal has a significant effect on the development of surface cracks and pore-damage characteristics of coal after liquid-nitrogen freezing and thawing, and there is a positive correlation between the surface crack expansion and internal damage of the coal samples of different moisture contents leached in liquid nitrogen.
Optimization studies of BTX removal by magnetite coated oleic acid obtained from microwave-assisted synthesis using response surface methodology
Authors: Masuku Makhosazana , Ouma Linda , Sanni Saheed , Pholosi Agnes
Published: November 2022

Benzene, toluene and xylene (BTX) are volatile organic compounds released into the environment, that require urgent removal to avoid adverse health effects. In this work, the modelling and optimization of the preparation factors for magnetite coated oleic acid (MNP-OA) composite from microwave synthesis using response surface methodology were conducted to maximize BTX removal, and iron content. The influence of five crucial preparation variables: the Fe3+/Fe2+ solution volumes, microwave power, volume of ammonia water (VAW), reaction time and volume of oleic acid (VOA) on the iron content (% Fe), and BTX adsorption capacity were investigated. The analysis of variance results revealed that VOA and VAW were the most influential factors for high % Fe content, and improved BTX removal. The % Fe, and BTX adsorption capacity for MNP-OA composite at optimized experimental conditions were estimated to be 85.57%, 90.02 mg/g (benzene), 90.07 mg/g (toluene), and 96.31 mg/g (xylene).