bluuebunny/crossref_metadata_2025 huggingface dataset:
Towards an ontology-based decision support system for syndrome-differentiation and treatment of Psoriasis Vulgaris in Traditional Chinese Medicine
Authors: Long Hai , Wang Zhe , Cui Yidi , Wang Junhui , Gao Bo , Chen Chao , Herre Heinrich , Zhu Yan
Published: December 2020

Background: Psoriasis is a chronic, non-communicable, painful, disfiguring and disabling disease, which is not curable and strongly declines the patients’ quality of life (QoL). However, diagnose and treatment in traditional Chinese medicine (TCM) based on syndrome differentiation has been used in practice for a long time and has also achieved some effect. Though, up to now, only few studies are available reporting on the use of semantic technologies and pertain to knowledge systems that use TCM-syndrome differentiation for information retrieval and automated reasoning. Nowadays, the diagnosis in TCM relies mainly on the personal expertise and clinical experience of the doctors. For various reasons, misdiagnoses or missed diagnoses cannot be completely excluded, leading to unexpected results.Methods In the present paper, we developed a domain ontology for syndrome differentiation of psoriasis vulgaris (PV). For this purpose, we used the ontology editor Protégé and applied a top-down approach which adopts the framework of general formal ontology (GFO) and its middle-level core ontology GFO-TCM. Furthermore, we implemented a prototype which is based on this ontology. Additionally, we also used a case-database for CBR (Case Based Reasoning) combined with fuzzy pattern recognition.Results: A prototype for diagnosis and treatment of psoriasis vulgaris, named ONTOPV-system, is proposed which is based on the principle of syndrome differentiation and treatment in TCM; this system realizes an expert-assisted decision support method which relies on a domain ontology, uses fuzzy logic reasoning, and case retrieval and is intended to support clinical diagnostic decisions for TCM practitioners.Conclusions: We designed and implemented a prototype for psoriasis diagnosis in terms of syndrome differentiation. The system realizes the basic functionalities of data collection, querying, browsing and navigation, and supports rule-based knowledge reasoning and integrates approximative reasoning, based on CBR and fuzzy logic. The system provides users with clinical decision support for TCM syndrome differentiation in diagnosis of psoriasis. In addition, it comprises a domain knowledge base of psoriasis, which is developed in the GFO framework with good extensibility.
Acute phase proteins and total antioxidant capacity in free-roaming cats infected by pathogenic leptospires
Authors: Picco Andrea Murillo , Cuenca Rafaela , Serrano Emmanuel , Tvarijonaviciute Asta , Cerón José , Marga Goris , Ahmed Ahmed , Pastor Josep
Published: December 2020

Background: Leptospirosis is a neglected but widespread zoonotic disease throughout the world. The vast majority of mammals are hosts of Leptospira spp., including domestic cats, species in which no consensus has been reached on the clinical presentation or diagnosis of the disease. The study of acute-phase proteins (APPs) and biomarkers of oxidative status would contribute to knowledge about the course of the disease in cats. In this report, we evaluated four APPs: Serum amyloid A-SAA, Haptoglobin–Hp, albumin and Paraoxonase 1-PON1 and the antioxidant response through Total Antioxidant Capacity-TAC, in 13 free-roaming cats naturally infected by pathogenic leptospires and 19 leptospires-free cats, through a Principal Component Analysis (PCA). Results: The PCA retained two principal components (PC1 and PC2), explaining 60.1% of the observed variability of the inflammatory proteins and the antioxidant TAC. PC1 was mainly associated with an inflammatory process, whereas PC2 correlated with the antioxidant status. The most contributing variables in PC1 where albumin (27.46%), SAA (24.71%), Hp (21.56%) and PON1 (20.69%). Variables with significant contribution to the PC2 were the antibody titre against Leptospira spp. (48.41%) and TAC (35.04%). Overall, the PCA revealed differences in inflammatory and antioxidant biomarkers in cats naturally infected with leptospires compared to leptospires-free cats.Conclusions: Increases in Serum SAA, Hp, and decreases in serum albumin concentrations and PON1 activity indicate an acute phase response in infected, DNA positive cats. Moreover, we found an increase in TAC serum concentrations indicating an antioxidant response in this infection, which was proportional to the antibody titre and not to the presence of bacterial DNA.
Liver transplantation in recipients with class III obesity: post-transplant outcomes and weight gain
Authors: Soma Daiki , Park Yujin , Mihaylov Plamen , Ekser Burcin , Ghabril Marwan , Lacerda Marco , Charasani Naga , Mangus Richard Shane , Kubal Chandrashekhar Avinash
Published: December 2020

Background Over the past decades, there has been a dramatic increase in obesity in the United States. Several studies have reported conflicting results for the impact of obesity on outcomes of liver transplantation (LT). This study aims to assess severe obesity's impact on LT outcomes and changes in body mass index (BMI) after transplantation.Methods All adult LT performed at Indiana University Health University Hospital between July 2001 and December 2018 were reviewed. A retrospective analysis for identified 2024 patients was conducted. BMI of recipients is subdivided into underweight, normal, overweight, class Ⅰ obesity, class Ⅱ obesity, and class Ⅲ obesity (<18.5; 18.5-24.9; 25‐29.9; 30‐34.9; 35‐39.9; ≥40 kg/m2, respectively). Survival outcomes were compared between each group. Post-transplant BMI was followed up in a sub-group of patients receiving LT from January 2008 to December 2018. A retrospective analysis for identified 1004 patients was conducted.Results Among 2024 patients in the analytic cohort, 1.9% were underweight, 24.5% were normal, 32.6% were overweight, 25% were in class Ⅰ obesity, 9.3% were in class Ⅱ obesity, and 1.1% were in class Ⅲ obesity. There was no significant difference in patient and graft survival at 10-year follow-up with respect to recipient obesity. The 1, 3, 5, and 10-year graft and patient survivals in class Ⅲ obesity group were 97.0%, 92.1%, 87.0%, and 79.8% for patient survival and 94.4%, 85.1%, 79.8%, and 72.5% for graft survival. Among 1004 patients identified in the sub-group, BMI of all groups except the underweight group declined in the first three months postoperatively. After the three months, the BMI of all groups except the class Ⅲ obesity group returned to the pre LT level by two years and reached a plateau by five years. In patients with class Ⅲ obesity, there was a significant increase in body weight after long-term follow-up.Conclusion In this study, class Ⅲ obesity is not associated with higher mortality. Obesity, including class Ⅲ obesity, should not be considered a contraindication to LT in the absence of other contraindications. Post-LT interventions are required to prevent significant weight gain in recipients with class Ⅲ obesity after transplantation.
Real-time metabolic heat-based specific growth rate soft sensor for monitoring and control of high molecular weight HA production by Streptococcus zooepidemicus.
Authors: Mohan Naresh , Pavan Satya Sai , Jayakumar Anjali , Rathinavelu Sivakumar , Sivaprakasam Senthilkumar
Published: December 2020

Background: Hyaluronic acid (HA) is an important mucopolysaccharide of higher molecular weight range and holds sheer economic interest. Its applications are widely acknowledged in rheumatoid arthritis treatment, tissue engineering, and cosmetics industries. This present investigation aims for the fed-batch production of high molecular weight range HA by application of real-time metabolic heat measurements. Results: Fed-batch strategies based on Feedforward (FF) and Feedback (FB) control was devised to improve the Molecular Weight (MW) of HA production by S. zooepidemicus . Metabolic heat measurements (Fermentation calorimetry) were modeled to decipher real-time specific growth rate, [[EQUATION]] was looped to the PID circuit, envisaged to control [[EQUATION]] to their desired setpoint values 0.05 [[EQUATION]] , 0.1 [[EQUATION]] and 0.15 [[EQUATION]] respectively. The developed FB strategy established a robust control on maintaining the specific growth rate (µ) close to the [[EQUATION]] value with a minimal tracking error. Exponential feed rate carried out with a lowest [[EQUATION]] of 0.05 [[EQUATION]] improved the MW of HA significantly to 2.98 MDa and 2.94 MDa for the FF and FB based control strategies respectively. An optimal HA titer of 4.73 g/L was achieved in a FF control strategy at [[EQUATION]] . Biomass and Lactic acid (LA) concentrations were found to be concomitant with the increase in [[EQUATION]] from 0.05 [[EQUATION]] to 0.15 [[EQUATION]] . Superior control of µ at low [[EQUATION]] value was observed to influence positively the HA polymerization attributing to improved MW and desired Polydispersity Index (PDI) of HA. Conclusions: This present investigation attempts to address the metabolic bottleneck in synthesis of high MW HA by S. zooepidemicus and illustrates the application of calorimetric fed-batch control of µ at a narrower range. PID control offers advantage over conventional fed-batch method to synthesize HA at an improved MW. Calorimetric signal based µ control by PID negates adverse effects due to the secretion of other metabolites albeit maintaining homeostasis.
Xenacoelomorpha flatworms are basal Deuterostome
Authors: Wang Yi
Published: December 2020

Background: Whether position Xenacoelomorpha as an early branch of Bilateria (Protostomes + Deuterostomes) has been intensely debated during last several decades. Considering Darwin’s “tree of life”, with the “Phylogenetic Species Concept”, we choose mitochondrial genome as the subject to predict phylogenetic position of Xenacoelomorpha, by genes genealogy. Results: Herein, we sequence Heterochaerus australis’s mitochondrial genome and infer intrinsic relationships of Metazoan with Xenacoelomorpha. The optimal tree under the popular maximum likelihood (ML) and Bayesian phylogenetic reconstructions are consensus with each other being strongly supported. The relationship between Chordates, Ambulacrarians and Xenoturbella/Acoelomorph is resolved. To avoid previous query about alignment process, the datasets are alignmented and trimmed automatically. Reducing taxon or cutting outgroups can not affect the relationship between Xenacoelomorpha and other Metazoan. Meanwhile, analysis using CAT model and Dayhoff groups also supporting the prediction made by mtZOA, relaxing the restriction of alignment criteria ( MAFFT, strategy G–ins–1, BLOSUM 62, 45, 30 ) introducing potential misleading signals can not challenge the tree topology indicating our auto-alignmented mitochondrial dataset is not artificially restricted one. Conclusions: Finally, a repeatable prediction of the genes genealogy with reliable statistical support places Xenacoelomorpha as a basal Deuterostome.
Post-abortion Family Planning Utilization and Associated Factors among Women Seeking Abortion Service: Cross-sectional Study
Authors: Woldemichael Dereje , Agero Gebi , Jima Aman , Woldemichael Bedasa
Published: December 2020

Background: Ethiopia is one of the developing countries with a high prevalence of unintended pregnancy and unsafe abortion. The aim of this study was to assess the utilization of post-abortion family planning and associated factors among women seeking abortion service in Asella Town health facilities, 2019. Methods: A facility based cross-sectional study design was conducted among women who came for abortion service from July 15 to October 15, 2019. Two hundred seventy-six participants were included using systematic random sampling technique. Both descriptive and logistic regression analyses were conducted. In multivariate analysis, variables which had a p-value < 0.05 was considered as significantly associated with the outcome variable. Results: Postabortion family planning utilization among study participants was 146 (53.7%) (95% CI=47.4, 59.2). Formal education (AOR=4.45: 95% CI: (1.18, 16.74)), previous history of abortion (AOR=0.35; 95% CI: (0.14, 0.85)), positive attitude to towards family planning (AOR=2.62; 95% CI: (1.09, 6.27)) and counseled on post abortion family planning utilization (AOR=3.12; 95% CI: (1.30, 7.51)) were significantly associated with post abortion family planning utilization. Conclusions: In this study, nearly fifty percent of the respondents did not utilize Postabortion Family Planning (PAFP). Educational status, history of pervious abortion, a decision when to have a child, attitude toward PAFP utilization and counseling about PAFP were significantly associated with post-abortion family planning utilization. The health care providers who give abortion service should give counseling for all women who get abortion service. More accents should be given to misperception of PAFP to change the negative attitude of utilization of PAFP.
Document, Archive, Memory in the Context of George Orwell’s Literary Heritage
Authors: Bezdrabko Valentyna V.
Published: December 2020

The article is devoted to the current topic of modern archival science – preserving the documentary heritage of mankind through information “cumulative” systems, in particular documents and archives. Particular attention is given to the role of the state, the individual, and the society in constituting memory. There are two types of memory: individual and collective, that is, culture. Memory, document, archive – concepts, and categories are polysemantic. Integral, broad-based importance belongs to culture (collective memory), which is seen as the interaction of the contemporary with the past in multifaceted socio-cultural manifestations. Collective memory, like individual memory, has its own traits of identification, serving as traces of the past. Memory is maintained through various forms of social existence (book, document, museum exhibit, antique item, etc.) and institutional cultural systems (museum, archive, library, etc.). The metadiscourse of the study was George Orwell’s “1984” novel Utopia, which uncovers the path of a free-spirited person with a distorted worldview to attempt to protect the memory space in the name of memory of the past and preserve it. The most important condition for an adequate examination of the social significance of documents in order to keep them permanently is to determine the degree of documentation of the reality of social relations, as well as the degree of representation and possible reconstruction, in addition to public memory focused on the life of an individual, and the memory of emotional. The author’s narrative in the form of diaries, memoirs, and letters allows revealing individual impressions of time, each specific epoch in the history of mankind. Everyday life forms an attitude towards documentary heritage at the domestic level, and the sphere of professional activity is an awareness of responsibility for the creation of history in the future on the basis of preserved data on a national, global scale. The influence of the form of government, the level of development of civil society, the degree of freedom, and the will of every citizen on the formation of world memory are also pointed out.

Keywords: document, archive, memory, collective memory, individual memory, state, society, George Orwell, “1984”.
Specifics of the Adult Healthcare System Formation of the New Socialist Industrial Cities of the Last Third of the 20th Century
Authors: Magsumov Timur A. , Nigmatullina Mariya O.
Published: December 2020

The author analyzes the therapeutic service development of the young city of the era of “developed socialism”, which eventually becomes the basis for the creation of the urban healthcare system in the late Soviet industrial centers. Both problems and achievements of its development are identified along with specific features of the urban healthcare system that had been formed at the beginning of the “Perestroika”, which eventually sharply distinguished the new socialist industrial centers from the cities of the European part of the country. During the period under consideration, a lot of work was done to establish a therapeutic service in the city of Naberezhnye Chelny. At the time the construction of industrial enterprises began, there was only one therapeutic unit in the central district hospital in the city. Later, hospitals and out-patient clinics were opened, healthcare centers and workshop services operated to treat the workers. Therapy was the basis of all specialized medical services, therefore, building up this service largely met the needs of the city under construction. As a result, specialized units were established on the basis of the therapeutic service, which subsequently operated as independent services. In the context of rapid demographic growth, the city was constantly expanding the network of medical institutions, increasing the number of employees along with facilities and equipment potential of medical institutions. This became the basis for the main result of the city’s therapeutic service activities during this period, i.e. the transition from the territorial-production principle of its patient service towards the territorial-specialized one. These undoubtedly positive results made it possible to maintain positive dynamics in the development of the city’s healthcare system in the subsequent years of the “Perestroika” and the collapse of the USSR, when the state of the industry as a whole declined sharply throughout the country.

Keywords: history of healthcare, therapeutic service, USSR, Naberezhnye Chelny, prevention and treatment institutions, developed socialism.
Case Study: An Improvement of Inspection Approach of Printed Multilayer Circuit Products Related to Visual Based Inspection Technique
Authors: Wan Yee Yap , Akhtar Mohammad Nishat , Abu Bakar Elmi
Published: December 2020

Product quality is an important issue in all manufacturing industry nowadays to meet the customers’ requirement. In this regard, most of the factory has a special department namely Quality Control (QC) Department which control the product quality. The studied factory is a flexible printed circuit board manufacturer which is located in Bayan Lepas, Pulau Pinang, Malaysia. QC Department of the studied factory has high amount of work-in-progress (WIP). Therefore, the products have to be sent out to subcontractors for quality inspection. However, this method is not economically effective. Hence, the objective of this study was to develop an improved inspection method which will reduce the overall inspection time of the current inspection method (CIM). By reducing the inspection time, productivity of the department will increase and subsequently reduce the amount of WIP. This study is focused on the improvement of one product only. Before the improved inspection method (IIM) of the selected product was developed, performance of the CIM was evaluated by using one of the graphical productivity analysis charting techniques which is flow process chart. It was found that the IIM was able to reduce the inspection time of whole inspection process by 85.06 sec for every 12 panels inspected.
On scalar products in higher rank quantum separation of variables
Authors: Maillet Jean Michel , Niccoli Giuliano , Vignoli Louis
Published: December 2020

Using the framework of the quantum separation of variables (SoV) for
higher rank quantum integrable lattice models , we introduce some
foundations to go beyond the obtained complete transfer matrix spectrum
description, and open the way to the computation of matrix elements of
local operators. This first amounts to obtain simple expressions for
scalar products of the so-called separate states, that are transfer
matrix eigenstates or some simple generalization of them. In the higher
rank case, left and right SoV bases are expected to be
pseudo-orthogonal, that is for a given SoV co-vector
\langle\underline{\mathbf{h}}\rangle⟨𝐡̲⟩,
there could be more than one non-vanishing overlap
\langle{\underline{\mathbf{h}}}|{\underline{\mathbf{k}}}\rangle⟨𝐡̲|𝐤̲⟩
with the vectors |{\underline{\mathbf{k}}}\rangle|𝐤̲⟩
of the chosen right SoV basis. For simplicity, we describe our method to
get these pseudo-orthogonality overlaps in the fundamental
representations of the \mathcal{Y}(gl_3)𝒴(gl3)
lattice model with NN
sites, a case of rank 2. The non-zero couplings between the co-vector
and vector SoV bases are exactly characterized. While the corresponding
SoV-measure stays reasonably simple and of possible
practical use, we address the problem of constructing left and right SoV
bases which do satisfy standard orthogonality (by standard we mean
\langle{\underline{\mathbf{h}}}|{\underline{\mathbf{k}}}\rangle \propto \delta_{\underline{\mathbf{h}}, \underline{\mathbf{k}}}⟨𝐡̲|𝐤̲⟩∝δ𝐡̲,𝐤̲).
In our approach, the SoV bases are constructed by using families of
conserved charges. This gives us a large freedom in the SoV bases
construction, and allows us to look for the choice of a family of
conserved charges which leads to orthogonal co-vector/vector SoV bases.
We first define such a choice in the case of twist matrices having
simple spectrum and zero determinant. Then, we generalize the associated
family of conserved charges and orthogonal SoV bases to generic simple
spectrum and invertible twist matrices. Under this choice of conserved
charges, and of the associated orthogonal SoV bases, the scalar products
of separate states simplify considerably and take a form similar to the
\mathcal{Y}(gl_2)𝒴(gl2)
rank one case.
Dr Mieczyslaw Jan de Sas Kropiwnicki (1912-1971): The first Polish veterinarian to perform a caesarean section on a brood mare
Authors: KNOTT MICHAEL , WITKOWSKI MACIEJ
Published: December 2020

The paper presents the life story of Dr Mieczysław Jan de Sas Kropiwnicki, Polish solder, member of the “Cichociemni” paratrooper group during World War II and a veterinarian, who practiced in RSA and who became famous after he had successfully performed a pioneering operation of a cesarean section on a mare in 1957. The tangled history of his life shows this great patriot entangled in the turbulent fates of the World War II and as a representative of our veterinarian profession, determined enough, to study veterinary medicine in Scotland (Edinburgh) once again, after his diploma from the Veterinary Medicine Academy in Lwów was lost, and then to nostrificate it to join the Royal College of Veterinary Surgeons to finally start his practice in RSA. A lot of details of Dr Kropiwnicki’s life were elaborated on by one of the authors – his grandson, who was born and raised in Africa and finally settled in Poland – the country of his grandfather’s origin, which was the place he had not been able to return to, but had been longing for all his life.
Gestão Orçamentária em Empresas Familiares
Authors: Lugoboni Leonardo Fabris , Miguel Ana Caroline Silva , Silva Bruna Alves Da , Oliveira Geovana De Morais , Santos Junior Valmir de Santana
Published: December 2020

O orçamento e o planejamento são ferramentas de gestão fundamentais atualmente, por proporcionarem uma visão ampla e atual da organização. Partindo desta premissa, o presente artigo tem como objetivo apresentar a pesquisa compreender como é o processo de construção, execução e controle do orçamento em empresas familiares. O projeto consiste no levantamento de dados com 5 empresas familiares distribuidoras de combustíveis, onde foram realizadas as entrevistas com os gerentes financeiros. Após a coleta dos dados, observou-se que o fato dos membros da família interferirem ou se envolverem diretamente na construção, execução e controle do orçamento, pode atrapalhar o processo  por meio de divergências de ideias entre os familiares, o que dificulta alguns procedimentos que poderiam ser resolvidos em dias, mas levam semanas para serem concluídos. Por outro lado, percebeu-se também que os processos ocorrem com mais agilidade, o que é um grande diferencial. Além disso, quando o profissionalismo dos familiares é bem estruturado, a empresa ganha um grande diferencial, gerando harmonia entre funcionários e diretores, o que aumenta a competitividade e rapidez.
Crack classification in rotor-bearing system by means of wavelet transform and deep learning methods: an experimental investigation
Authors: Nima Rezazadeh , Shila Fallahy
Published: December 2020

Parallel with significant growth in industry, especially mysteries related to energy engineering, condition monitoring of rotating systems have been experiencing a noticeable increase. One of the prevalent faults in these systems is fatigue crack, so finding reliable procedures in identification of cracks in rotating shafts has become a pressing problem among engineers during recent decades. While a vast majority of cracked rotors can operate for a specific period of time, to prevent catastrophic failures, crack detection and measuring its characteristics (i.e. size and its location) seem to be essential. In the present essay, a hybrid procedure, consisting of Deep Learning and Discrete Wavelet transform (DWT), is applied in detection of a breathing transverse crack and its depth in a rotor-bearing-disk system. DWT with Daubechies 32(db32) as wavelet mother function is applied in signal noise reduction until level 6, also its Relative Wavelet Energy (RWE) and Wavelet entropy (WE) are extracted. A characteristic vector that is a combination of RWE and WE is considered as input to a multi-layer Artificial Neural Network (ANN). In this supervised learning classifier, a multi-layer Perceptron neural network is used; in addition, Rectified Linear Unit (ReLU) function is exerted as activation function in both hidden and output layers. By comparing the results, it can be seen that the applied procedure has strong capacity in identification of crack and its size in the rotor system.
AS AÇÕES DE IMPLANTAÇÃO DA LEI Nº 12.244/2010 NOS MUNICÍPIOS DA GRANDE VITÓRIA/ES
Authors: Pereira Gleice , Nogueira Rodrigues Sobrinho Patrícia , Teixeira Girelli Ricardo
Published: December 2020

Resumo: A pesquisa objetiva analisar se a Lei nº. 12.244/2010 está sendo implantada ou em processo de implantação nas quatro prefeituras da Grande Vitória/ES, tendo em vista que o prazo para efetivação está se encerrando. Essa questão despertou interesse, pois o Governo Federal tem dedicado esforços para melhorias da educação. A biblioteca escolar, que está inserida nesse espaço, tem leis que a beneficiam, porque faz parte do processo de ensino- aprendizagem do aluno. Por meio de visitas in loco e por ofício enviado às Secretarias de Educação, busca-se conhecer a realidade das bibliotecas. Este estudo constatou que somente duas prefeituras têm efetivamente caminhado para a implantação da Lei nº. 12.244/2010. Espera-se, contudo, que a implantação da lei seja um reconhecimento, por parte da equipe docente, da família e dos alunos, de que a biblioteca escolar é um espaço de aprendizagem.
Pathways Related to the Anti-Cancer Effects of Metabolites Derived from Cerrado Biome Native Plants: An Update and Bioinformatics Analysis on Oral Squamous Cell Carcinoma
Authors: Xavier Guilherme Machado , Guimarães André Luiz Sena , de Carvalho Fraga Carlos Alberto , Guimarães Talita Antunes , de Souza Marcela Gonçalves , Jones Kimberly Marie , Farias Lucyana Conceição
Published: December 2020

Background::

Oral cancer is a significant health problem worldwide. Oral squamous cell carcinoma (OSCC) is a malignant neoplasm of epithelial cells that mostly affects different anatomical sites in the head and neck and derives from the squamous epithelium or displays similar morphological characteristics. Generally, OSCC is often the end stage of several changes in the stratified squamous epithelium, which begin as epithelial dysplasia and progress by breaking the basement membrane and invading adjacent tissues. Several plant-based drugs with potent anti-cancer effects are considered inexpensive treatments with limited side effects for cancer and other diseases.

Objective::

The aim of this review is to explore whether some Brazilian plant extracts or constituents exhibit anti-tumorigenic activity or have a cytotoxic effect on human oral carcinoma cells.

Methods::

Briefly, OSCC and several metabolites derived from Brazilian plants (i.e., flavonoids, vinblastine, irinotecan, etoposide and paclitaxel) were used as keywords to search the literature on PubMed, GenBank and GeneCards.

Results::

The results showed that these five chemical compounds found in Cerrado Biome plants exhibit anti-neoplastic effects. Evaluating the compounds revealed that they play a main role in the regulation of cell proliferation.

Conclusion::

Preserving and utilising the biodiversity of our planet, especially in unique ecosystems, such as the Cerrado Biome, may prove essential to preserving and promoting human health in modern contexts.
Natural Products Homoharringtonine and Emetine Alkaloids as SARS-CoV-2 Treatment Options
Authors: Sohrab Sayed S. , Suhail Mohd , Kamal Mohammad A. , Azhar Esam I.
Published: December 2020

Background:

Viruses are known as the major causative agents for infectious diseases globally. The
coronaviruses are one of the serious pathogens to cause serious diseases in humans. Recently identified SARSCoV-
2 from Wuhan City, China, has emerged as a serious threat to human health and caused a global pandemic.
Bats have been confirmed as a primary source of infection. The vaccination of the human population and animals
serving as a potential reservoir is a straightforward strategy to control the transmission of any pathogen to
humans. Natural products from many herbal plants are well known to have novel antiviral properties and evaluated
against various viral diseases. There are many alkaloids that have shown to be effective against coronaviruses.

Methods:

Recently, the antiviral efficacy of natural alkaloids known as Homoharringtonine (HTT) and Emetine
has been evaluated and provided promising results against coronaviruses, including SARS-CoVs. These alkaloids
may be very useful and can be used as antivirals against SARS-CoV-2 because they have already been reported
to inhibit the replication of SASRS-CoV and other viruses in cell lines.

Conclusion:

This review specifically focuses on the recent findings of these alkaloids against coronaviruses
and possible treatment options for SARS-CoV-2. It is expected that natural products as alkaloids from herbal
plants could be considered as novel and valuable candidates for the new antiviral drugs against SARS-CoV-2.
Current Quest in Natural Bioactive Compounds for Alzheimer’s Disease: Multi-Targeted-Designed-Ligand Based Approach with Preclinical and Clinical Based Evidence
Authors: Iqubal Ashif , Rahman Syed Obaidur , Ahmed Musheer , Bansal Pratichi , Haider Md Rafi , Iqubal Mohammad Kashif , Najmi Abul Kalam , Pottoo Faheem Hyder , Haque Syed Ehtaishamul
Published: December 2020

Alzheimer’s disease is a common and most chronic neurological disorder (NDs) associated with cognitive dysfunction. Pathologically, Alzheimer’s disease (AD) is characterized by the presence of β-amyloid (Aβ) plaques, hyper-phosphorylated tau proteins, and neurofibrillary tangles, however, persistence oxidative-nitrative stress, endoplasmic reticulum stress, mitochondrial dysfunction, inflammatory cytokines, pro-apoptotic proteins along with altered neurotransmitters level are common etiological attributes in its pathogenesis. Rivastigmine, memantine, galantamine, and donepezil are FDA approved drugs for symptomatic management of AD, whereas tacrine has been withdrawn because of hepatotoxic profile. These approved drugs only exert symptomatic relief and exhibit poor patient compliance. In the current scenario, the number of published evidence shows the neuroprotective potential of naturally occurring bioactive molecules via their antioxidant, anti-inflammatory, antiapoptotic and neurotransmitter modulatory properties. Despite their potent therapeutic implications, concerns have arisen in context to their efficacy and probable clinical outcome. Thus, to overcome these glitches, many heterocyclic and cyclic hydrocarbon compounds inspired by natural sources have been synthesized and showed improved therapeutic activity. Computational studies (molecular docking) have been used to predict the binding affinity of these natural bioactive as well as synthetic compounds derived from natural sources for the acetylcholine esterase, α/β secretase Nuclear Factor kappa- light-chain-enhancer of activated B cells (NF-kB), Nuclear factor erythroid 2-related factor 2(Nrf2) and other neurological targets. Thus, in this review, we have discussed the molecular etiology of AD, focused on the pharmacotherapeutics of natural products, chemical and pharmacological aspects and multi-targeted designed ligands (MTDLs) of synthetic and semisynthetic molecules derived from the natural sources along with some important on-going clinical trials.
Renal Function, Albumin-Creatinine Ratio and Pulse Wave Velocity Predict Silent Coronary Artery Disease and Renal Outcome in Type 2 Diabetic and Prediabetic Subjects
Authors: Sanchez Ramiro A. , Sanchez Maria J. , Ramirez Agustin J.
Published: December 2020

Introduction:

Silent coronary heart disease is frequently undetected in type 2 diabetes
mellitus (DM2) and pre-diabetes determined by glucose intolerance (GI).
Pulse wave velocity (PWV) and albumin-creatinine ratio (ACR) have been considered markers of
cardiovascular mortality, coronary heart disease and chronic renal failure.

Aims:

To evaluate the incidence of coronary artery disease (CAD) and the relationship between urinary
albumin-creatinine ratio, glomerular filtration rate (GFR) and PWV in type 2 DM with silent
CAD.

Methods:

We analyzed 92 individuals (44 male), 49 (60±7y) type 2 DM non-insulin dependents
and 43 prediabetics (43±4y), with Grade I-II hypertension and no symptoms of CAD.

:

All type 2 DM patients were under antidiabetic treatment with A1C hemoglobin between 5.5 and
6.5%.

:

Every patient underwent a myocardial perfusion SPECT scan. In those subjects with ischemic patterns,
coronary angiography was performed. In addition, PWV, glomerular filtration rate, and ACR
were evaluated. Statistics: mean±SEM, and ANOVA among groups.

Results:

48.59% of DM2 and 25.58% of GI patients had silent coronary artery had silent coronary
artery disease and higher ACR, PWV and reduced GFR. Higher ACR and PWV and reduced GFR.
DM2 and GI showed a negative relationship between GFR and ACR. Moreover, this relation was
also observed in different levels of GFR (>60 ml/min and <60ml.min (p<0.05) in patients with
CAD, suggesting a cardio-renal interaction in DM2.

Conclusions:

Higher PWV, lower GFR and ACR predict the incidence of CAD in DM2. Dysglycemic
individuals also represent a group of higher risk for coronary artery disease with similar
predictors as in DM2. Diabetic and prediabetics still develop renal microalbuminuria. Thus, PWV
seems to represent a reliable marker of renal impairment and coronary artery disease.
Relationship between Hyperlipidemia, Cardiovascular Disease and
Stroke: A Systematic Review
Authors: Alloubani Aladeen , Nimer Refat , Samara Rama
Published: December 2020

Background::

Globally, dyslipidemia has been shown to be an independent predictor of many cardiovascular and cerebrovascular events, which lead to recent advocacy towards dyslipidemia prevention and control as a key risk factor and its prognostic significance to reduce the burden of stroke and myocardial infarction.

Aim::

This study aimed to evaluate hyperlipidemia as a risk factor connected with stroke and CVD. Moreover, having identified this risk factor, the study evaluates how hyperlipidemia has been examined earlier and what can be done in the future.

Methods::

All prospective studies concerning hyperlipidemia as risk factors for stroke and CVD were identified by a search of PubMed/MEDLINE and EMBASE databases with keywords hyperlipidemia, risk factors, stroke, and cardiovascular disease.

Results::

The constant positive association between the incidence of coronary heart disease and cholesterol concentration of LDL is apparent in observational studies in different populations. Thus, the reduction of LDL cholesterol in those populations, particularly with regard to initial cholesterol concentrations, can reduce the risk of vascular diseases. However, the impact of using lipid-lowering drugs, such as statins, has been demonstrated in several studies as an important factor in decreasing the mortality and morbidity in rates of patients with stroke and CVD.

Conclusion::

After reviewing all the research mentioned in this review, it can be confirmed that hyperlipidemia is a risk factor for stroke and correlated in patients with CVD.
Withdrawal Notice: An Efficient Approach for Detection and Verification of Infected Cases of Covid-19 Virus through Block Chain: A Survey
Authors: Gupta Kanika , Jamshed Aatif
Published: December 2020

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Animals: Uma releitura floydiana de Animal Farm
Authors: De Campos Marcia Cristina Maeno
Published: December 2020

Em 1944, o escritor britânico George Orwell publicou Animal Farm, traduzida em português como A Revolução dos Bichos. Através de signos fortes, como os personagens animais, dentre os quais os porcos ao longo da obra transmutam-se em humanos, e os artefatos humanos, este artigo analisa o poder destes signos nos planos narrativo e de crítica moral-filosófica desta ‘nouvella’, assim como os do disco lançado trinta anos depois pela banda de rock progressivo inglesa Pink Floyd: Animals.
Helder Macedo: O ensaio como gesto amoroso
Authors: Braga Mariana
Published: December 2020

Este artigo pretende analisar possíveis pontos de interseção semânticos e estruturais entre o género epistolar e o género ensaístico na obra crítica de Helder Macedo. Tomarei como objeto de estudo Camões e outros contemporâneos (2017), sua mais nova coletânea de textos críticos revisitados, a qual inclui quatro ensaios sobre Luís de Camões. Entre eles destaca-se “Camões: o imaginário da malandragem”, em que o ensaísta se debruça sobre cartas cuja autoria é atribuída ao poeta. Para refletir sobre a importância do amor na obra de Helder Macedo – como tema, força motriz e modus operandi –, será fundamental o estudo de semiótica Presenças do outro (2002), de Eric Landowski, no qual há um capítulo dedicado especificamente às cartas de amor, entendidas como um meio pelo qual se procura tornar presente o outro ausente, ou seja, como ato de presentificação do outro.
Equivalência contextual na tradução entre Chinês e Português – Análise de alguns casos concretos
Authors: Suoying Wang , Yanbin Lu
Published: December 2020

Este trabalho visa explicar a importância do valor contextual na tradução entre chinês e português, através da análise de casos verificados na prática de docência e tradução.
Estudo semânticocomparativo do sistema de artigos em Português e dos mecanismos de marcação de determinação em Chinês
Authors: Zhang Jing
Published: December 2020

Um traço diferenciador entre a língua portuguesa e a língua chinesa é que a primeira possui um sistema de artigos e a segunda recorre a outros mecanismos para marcar a definitude no sintagma nominal (SN). O presente trabalho compara as duas línguas, descrevendo a relação entre os dois sistemas de marcação de determinação e os tipos de SN classificados com base no modelo dos dois traços binários de Huebner (1983), segundo o qual o uso do artigo depende das propriedades semânticas do SN. Os resultados do estudo comparativo contribuem para ajudar os alunos de língua materna chinesa a entender melhor como aplicar corretamente os artigos portugueses, estando cientes de que os artigos portugueses codificam a definitude, não a especificidade.
Adaptação acentual de empréstimos Japoneses em Português Brasileiro
Authors: Agostinho Ana Lívia , Richter Lara
Published: December 2020

Este artigo investiga a adaptação de acento de empréstimos de origem japonesa no português brasileiro. A partir de um corpus lexical composto por empréstimos, observou-se como ocorre a adaptação acentual através de dados de fala gravados no bairro da Liberdade, em São Paulo, Brasil, com o objetivo de comparar a produção de falantes de português brasileiro descendentes e não descendentes de japoneses. A partir da análise dos dados, concluiu-se que o acento oxítono é produtivo no português brasileiro, uma vez que está presente em 49% dos dados de fala de falantes de ascendência não japonesa, e em 52% de falantes de ascendência japonesa. Além disso, 67% dos dados de fala que não possuem sílaba pesada final em japonês foram adaptados com acento final. Também foi observado que há uma tendência para que vogais longas do japonês sejam adaptadas para o português brasileiro como sílabas acentuadas por conta da duração, enquanto o pitch-accent do japonês não é reconhecido ou reproduzido neste processo de adaptação.
Linguagem e poder nas mídias brasileira e portuguesa
Authors: Seara Isabel Roboredo , Dos Santos Leonor Werneck
Published: December 2020

Este estudopropõe ampliar a discussão teóricasobre referenciação, analisando artigos de opinião que tratam de temas associados à violência, publicados na mídiaem Portugal e no Brasil. Na perspetivateórica, serão discutidos tópicos referentes à correferencialidade e àinferencialidade necessárias para a identificação dos objetos de discurso, seguindo o aporte teórico da Linguística de Texto e de outras pesquisas com viés textual-discursivo, como Fonseca (1992), Fuchs (1992), Apotheloz e Reichler-Béguelin (1995), Koch e Marcuschi (1998), Mondada e Dubois (2003), Cornish (2011) Maalej (2011), Pecorari (2015), Cabral e Santos (2016), entre outros.Convocamos igualmente alguns pressupostos sobre argumentação, alicerçando a reflexão nos estudos de Ducrot (1988), Charaudeau (2008) e Amossy (2008, 2009). Nosso propósito é descrever o comportamento das anáforas como marcadores axiológicos da condução argumentativa dos textos com temática política, polarizando a complexa rede de poder. Pretendemos, portanto, colaborar nos estudos de interface entre referenciaçãoe gênero textual, especificamente em se tratando de gêneros textuais aos quais os leitores têm fácil acesso via Web, demonstrando como anáfora e dêixis podem ajudar a marcar ideologicamente o texto.
Arte / Resistência. A ‘Itália’ em Torga e Saramago
Authors: Grossegesse Orlando
Published: December 2020

Miguel Torga e José Saramago, ambos os escritores não só fizeram viagens a Itália – em momentos históricos diferentes, 1937–38 e 1972, respetivamente – mas também escreveram sobre ‘Itália’ com base nestas experiências. No caso de Torga, O Quarto Dia (1939; reed. 1971) da Criação do Mundo, e no caso de Saramago, algumas crónicas (1972) e os cinco exercícios de autobiografia do pintor H. em Manual de Pintura e Caligrafia (1977). Partindo da hipótese de uma receção produtiva por parte de Saramago, este estudo faz uma análise comparativa que se centra na imagem ambivalente da ‘Itália’ (pátria da Arte e berço do fascismo). Esta análise culmina na definição de uma evolução do pensamento sobre a Arte e sobre o papel do artista perante a opressão política e a perseguição do ser humano como portador do pensamento e da criação que desafia as estruturas de poder. Em vez de a práxis artística se centrar na sublimação e em ser funcionalizada para a ostentação do poder, ela deve assumir um papel no âmbito da resistência e do despertar para uma consciência política individual e coletiva emancipadora. Esta evolução passa pela redefinição da estética, despoletada pela contemplação de obras de Arte em Itália que entra em diálogo com observações e reflexões. Assim sendo, confere-se aos respetivos textos de Torga e Saramago uma dimensão poetológica que será analisada de forma comparativa.
Konflik Pemilihan Kepala Dusun Depok Ambarketawang Gamping Sleman Yogyakarta
Authors: Adhilani Denanda Putri , Hanum Farida
Published: December 2020

Penelitian ini mendeskripsikan latar belakang, faktor penyebab, dan upaya yang sudah dilakukan untuk menyelesaikan konflik pemilihan kepala dusun Depok Ambarketawang. Penelitian ini menggunakan metode kualitatif deskriptif. Pengambilan sampel menggunakan teknik purposive sampling dengan jumlah informan 8 orang. Teknik pengumpulan data dilakukan dengan wawancara, observasi, dan dokumentasi. Validitas data yang digunakan adalah triangulasi sumber. Teknik analisis data menggunakan teknik analisis data milik Miles dan Huberman meliputi pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil dari penelitian ini menunjukkan bahwa konflik tersebut dilatar belakangi oleh pemilihan kepala dusun melalui musyawarah dusun dan tes. Faktor penyebab konflik tersebut adalah kurangnya pemahaman masyarakat tentang peraturan daerah yang baru, dukuh terpilih tidak sesuai dengan keinginan masyarakat, kurangnya sosialisasi pada masyarakat tentang calon dukuh, dan adanya pengaruh dari kelompok tertentu. Adapun upaya yang sudah dilakukan untuk mengatasi konflik pada pemilihan kepala dusun tersebut antara lain kepala desa berusaha menjelaskan peraturan daerah yang baru pada masyarakat, negosiasi yang dilakukan oleh kepala desa, mediasi mempertemukan dukuh terpilih dengan masyarakat, dan dukuh terpilih mengundurkan diri.
Долгожданное продолжение публикации Законодательных актов Петра I Н. А. Воскресенского
Authors: Киселев Михаил
Published: December 2020

Рецензия на книгу: Законодательные акты Петра I. Редакции и проекты законов, заметки, доклады, доношения, челобитья и иностранные источники. Сборник документов. В 3 тт. / Сост. Н. А. Воскресенский. Т. II: Акты об общественных классах; Т. III: Акты о промышленности и торговле / Отв. ред. Е. В. Анисимов; предисл. и подгот. текста Д. О. Серов; археограф. предисл. А. А. Богданов. Москва: Древлехранилище, 2020. 848 с.
Technology fusion of metal injection moulding and selective laser melting for the manufacture of complex and multifunctional (hydraulic) components
Authors: Herold Martin , Zopp Camilo , Neiske Oliver , Schubert Frank , Hustert Jan , Nendel Wolfgang , Kroll Lothar
Published: December 2020

Selective laser melting (SLM) and metallic injection moulding (MIM) are established processes for the production of high-performance metallic components for small and large series. In the aerospace industry, where very high demands are placed on materials and components, both processes are still considered to be relatively new. In both processes, the conventional titanium alloy Ti-6Al-4V can be used in the form of powder. Currently, both technologies are only considered separately. By fusing components of the same type, multifunctional components with a high lightweight construction potential can be produced.

In order to generate direct material fusion, the MIM component must be mechanically processed accordingly. In addition, suitable SLM process parameters must be developed in order to ensure both generative construction and high joint strength. To this end, a characterisation of the joining zone and the static joint strength was carried out. Furthermore, pressure test samples were designed and examined both statically and for fatigue strength. Thus, a high static joint strength could be proven. The compression test samples also withstood a fatigue strength of over 1 million cycles.