bluuebunny/crossref_metadata_2025 huggingface dataset:
The Affidavit
Authors: Melville Herman , Blum Hester
Published: February 2023

So far as what there may be of a narrative in this book; and, indeed, as indirectly touching one or two very interesting and curious particulars in the habits of sperm whales, the foregoing chapter, in its earlier part, is as important a one...
The Albatross
Authors: Melville Herman , Blum Hester
Published: February 2023

South-eastward from the Cape, off the distant Crozetts, a good cruising ground for Right Whalemen, a sail loomed ahead, the Goney (Albatross) by name. As she slowly drew nigh, from my lofty perch at the fore-mast-head, I had a good view of that sight...
Of the Monstrous Pictures of Whales
Authors: Melville Herman , Blum Hester
Published: February 2023

I shall ere long paint to you as well as one can without canvas, something like the true form of the whale as he actually appears to the eye of the whaleman when in his own absolute body the whale is moored alongside...
Of Whales in Paint; In Teeth; In Wood; In Sheet-Iron; In Stone; In Mountains; In Stars
Authors: Melville Herman , Blum Hester
Published: February 2023

On Tower-hill, as you go down to the London docks, you may have seen a crippled beggar (or kedger, as the sailors say) holding a painted board before him, representing the tragic scene in which he lost his leg. There...
The Line
Authors: Melville Herman , Blum Hester
Published: February 2023

With reference to the whaling scene shortly to be described, as well as for the better understanding of all similar scenes elsewhere presented, I have here to speak of the magical, sometimes horrible whale-line.

The line originally used in the fishery was of the best...
The Blanket
Authors: Melville Herman , Blum Hester
Published: February 2023

I have given no small attention to that not unvexed subject, the skin of the whale. I have had controversies about it with experienced whalemen afloat, and learned naturalists ashore. My original opinion remains unchanged; but it is only an opinion....

The question is,...
The Monkey-Rope
Authors: Melville Herman , Blum Hester
Published: February 2023

In the tumultuous business of cutting-in and attending to a whale, there is much running backwards and forwards among the crew. Now hands are wanted here, and then again hands are wanted there. There is no staying in any one place; for at one...
The Right Whale’s Head.—Contrasted View
Authors: Melville Herman , Blum Hester
Published: February 2023

Crossing the deck, let us now have a good long look at the Right Whale’s head.

As in general shape the noble Sperm Whale’s head may be compared to a Roman war-chariot (especially in front, where it is so broadly rounded); so, at a broad...
The Praire
Authors: Melville Herman , Blum Hester
Published: February 2023

To scan the lines of his face, or feel the bumps on the head of this Leviathan; this is a thing which no Physiognomist or Phrenologist has as yet undertaken. Such an enterprise would seem almost as hopeful as for Lavater to have scrutinized...
The Nut
Authors: Melville Herman , Blum Hester
Published: February 2023

If the Sperm Whale be physiognomically a Sphinx, to the phrenologist his brain seems that geometrical circle which it is impossible to square.

In the full-grown creature the skull will measure at least twenty feet in length. Unhinge the lower jaw, and the side view...
The Decanter
Authors: Melville Herman , Blum Hester
Published: February 2023

Ere the English ship fades from sight, be it set down here, that she hailed from London, and was named after the late Samuel Enderby, merchant of that city, the original of the famous whaling house of Enderby & Sons; a house which in...
Ahab’s Leg
Authors: Melville Herman , Blum Hester
Published: February 2023

The precipitating manner in which Captain Ahab had quitted the Samuel Enderby of London, had not been unattended with some small violence to his own person. He had lighted with such energy upon a thwart of his boat that his ivory leg had received...
The Carpenter
Authors: Melville Herman , Blum Hester
Published: February 2023

Seat thyself sultanically among the moons of Saturn, and take high abstracted man alone; and he seems a wonder, a grandeur, and a woe. But from the same point, take mankind in mass, and for the most part, they seem a mob...
The Gilder
Authors: Melville Herman , Blum Hester
Published: February 2023

Penetrating further and further into the heart of the Japanese cruising ground, the Pequod was soon all astir in the fishery. Often, in mild, pleasant weather, for twelve, fifteen, eighteen, and twenty hours on the stretch, they were engaged in the boats, steadily pulling,...
The Dying Whale
Authors: Melville Herman , Blum Hester
Published: February 2023

Not seldom in this life, when, on the right side, fortune’s favorites sail close by us, we, though all adroop before, catch somewhat of the rushing breeze, and joyfully feel our bagging sails fill out. So seemed it with the Pequod. For next day...
Midnight. — The Forecastle Bulwarks
Authors: Melville Herman , Blum Hester
Published: February 2023

Stubb and Flask mounted on them, and passing additional lashings over the anchors there hanging

“No, Stubb; you may pound that knot there as much as you please, but you will never pound into me what you were just now saying. And how...
The Log and Line
Authors: Melville Herman , Blum Hester
Published: February 2023

While now the fated Pequod had been so long afloat this voyage, the log and line had but very seldom been in use. Owing to a confident reliance upon other means of determining the vessel’s place, some merchantmen, and many whalemen, especially...
The Cabin
Authors: Melville Herman , Blum Hester
Published: February 2023

(Ahab moving to go on deck; Pip catches him by the hand to follow)

“Lad, lad, I tell thee thou must not follow Ahab now. The hour is coming when Ahab would not scare thee from him, yet would not have...
The Pequod Meets the Delight
Authors: Melville Herman , Blum Hester
Published: February 2023

The intense Pequod sailed on; the rolling waves and days went by; the life-buoy-coffin still lightly swung; and another ship, most miserably misnamed the Delight, was descried. As she drew nigh, all eyes were fixed upon her broad beams, called shears, which, in some...
Tweedledum and Tweedledee
Authors: Carroll Lewis , Jaques Zoe
Published: February 2023

they were standing under a tree,* each with an arm round the other’s neck, and Alice knew which was which in a moment, because one of them had ‘DUM’ embroidered on his collar, and the other ‘DEE.’ “I suppose they’ve each...
Wool and Water
Authors: Carroll Lewis , Jaques Zoe
Published: February 2023

She caught the shawl as she spoke, and looked about for the owner: in another moment the White Queen came running wildly through the wood, with both arms stretched out wide, as if she were flying, and Alice very civilly went to meet her...
The Lion and the Unicorn
Authors: Carroll Lewis , Jaques Zoe
Published: February 2023

the next moment soldiers came running through the wood, at first in twos and threes, then ten or twenty together, and at last in such crowds that they seemed to fill the whole forest. Alice got behind a tree, for fear of being run...
Use of Correct and Incorrect Methods of Accounting for Age in Studies of Epigenetic Accelerated Aging: Implications and Recommendations for Best Practices
Authors: Krieger Nancy , Chen Jarvis T , Testa Christian , Diez Roux Ana , Tilling Kate , Watkins Sarah , Simpkin Andrew J , Suderman Matthew , Davey Smith George , De Vivo Immaculata , Waterman Pamela D , Relton Caroline
Published: February 2023

Motivated by our conduct of a literature review on social exposures and accelerated aging as measured by a growing number of epigenetic “clocks” (which estimate age via DNA methylation (DNAm) patterns), we report on 3 different approaches in the epidemiologic literature—1 incorrect and 2 correct—on the treatment of age in these and other studies using other common exposures (i.e., body mass index and alcohol consumption). Among the 50 empirical articles reviewed, the majority (n = 29; 58%) used the incorrect method of analyzing accelerated aging detrended for age as the outcome and did not control for age as a covariate. By contrast, only 42% used correct methods, which are either to analyze accelerated aging detrended for age as the outcome and control for age as a covariate (n = 16; 32%) or to analyze raw DNAm age as the outcome and control for age as a covariate (n = 5; 10%). In accord with prior demonstrations of bias introduced by use of the incorrect approach, we provide simulation analyses and additional empirical analyses to illustrate how the incorrect method can lead to bias towards the null, and we discuss implications for extant research and recommendations for best practices.
Invited Commentary: Cross-Sectional Studies and Causal Inference—It’s Complicated
Authors: Barnett Tracie A , Koushik Anita , Schuster Tibor
Published: February 2023

In this issue of the Journal, Savitz and Wellenius (Am J Epidemiol. 2023;192(4):514–516) discuss the contribution of cross-sectional studies to causal inference when the data are used to address etiological research questions. We elaborate on their thoughts with a discussion of the conditions needed for addressing etiology with the cross-sectional design, using a modern causal inference lens.
NMRtist: an online platform for automated biomolecular NMR spectra analysis
Authors: Klukowski Piotr , Riek Roland , Güntert Peter
Published: February 2023

We present NMRtist, an online platform that combines deep learning, large-scale optimization and cloud computing to automate protein NMR spectra analysis. Our website provides virtual storage for NMR spectra deposition together with a set of applications designed for automated peak picking, chemical shift assignment and protein structure determination. The system can be used by non-experts and allows protein assignments and structures to be determined within hours after the measurements, strictly without any human intervention.

Availability and implementation

NMRtist is freely available to non-commercial users at https://nmrtist.org.

Supplementary information

Supplementary data are available at Bioinformatics online.
Sex-specific differences in the standard of care for infrarenal abdominal aortic aneurysm repair, and risk of major adverse cardiovascular events and death
Authors: Pouncey Anna L , Sweeting Michael J , Bicknell Colin , Powell Janet T
Published: February 2023

Background

This study investigated whether sex-specific differences in preoperative/perioperative standard of care (SOC) account for disparity in outcomes after elective infrarenal abdominal aortic aneurysm repair.

Methods

This was a retrospective cohort study of elective infrarenal abdominal aortic aneurysm repairs (2013–2020) using depersonalized patient-level National Vascular Registry data. SOC was defined for waiting times, preoperative assessment (multidisciplinary/anaesthetic review), cardiovascular risk prevention, and perioperative medication. The primary outcome was major cardiovascular event and/or death (MACED).

Results

Some 21 810 patients with an infrarenal abdominal aortic aneurysm were included, 2380 women and 19 430 men. Women less often underwent aneurysm repair within SOC waiting times (51.5 versus 59.3 per cent; P < 0.001), but were equally likely to receive preoperative assessment (72.1 versus 72.5 per cent; P = 0.742). Women were less likely to receive secondary prevention for known cardiac disease (34.9 versus 39.6 per cent; P = 0.015), but more often met overall cardiovascular risk prevention standards (52.1 versus 47.3 per cent; P < 0.001). Women were at greater risk of MACED (open: 12.0 versus 8.9 per cent, P < 0.001; endovascular: 4.9 versus 2.9 per cent, P < 0.001; risk-adjusted OR 1.33, 95 per cent c.i. 1.12 to 1.59). A significant reduction in the odds of MACED was associated with preoperative assessment (OR 0.86, 0.75 to 0.98) and SOC waiting times (OR 0.78, 0.69 to 0.87). There was insufficient evidence to confirm a significant sex-specific difference in the effect of SOC preoperative assessment (women: OR 0.69, 0.50 to 0.97; men: OR 0.89, 0.77 to 1.03; interaction P = 0.170) or SOC waiting times (women: OR 0.84, 0.62 to 1.16; men: OR 0.76, 0.67 to 0.87; interaction P = 0.570) on the risk of MACED.

Conclusion

SOC waiting times and preoperative assessment were not met for both sexes, which was associated with an increased risk of MACED. Sex-specific differences in SOC attenuated but did not fully account for the increased risk of MACED in women.
CD4/CD8 Ratio Outcome According to the Class of the Third Active Drug in Antiretroviral Therapy Regimens: Results From the Quebec Human Immunodeficiency Virus Cohort Study
Authors: Sangaré Mohamed N’dongo , Baril Jean-Guy , de Pokomandy Alexandra , Klein Marina , Thomas Réjean , Tremblay Cécile , Pexos Costa , Durand Madeleine , Chawla Seerat , Laporte Louise , Trottier Helen
Published: February 2023

Background

The impact of different therapeutic classes of drugs in antiretroviral therapy (ART) regimens on the CD4/CD8 ratio is not well documented in people treated for HIV. The objective of this study was to analyze the long-term effect of exposure to integrase strand transfer inhibitor (INSTI) on CD4/CD8 ratio compared with nonnucleoside reverse transcriptase inhibitor (NNRTI) or protease inhibitor (PI) among ART-treated persons with HIV (PWH).

Methods

Data from the Quebec HIV Cohort collected from 31 August 2017 were used. Our analysis included all patients in the cohort who received a first or subsequent ART regimen composed of 2 nucleoside reverse transcriptase inhibitors (NRTIs) and a third active drug of a different class (NNRTI, PI, or INSTI) for at least 16 weeks. Marginal structural Cox models were constructed to estimate the effect of different therapeutic classes on the CD4/CD8 ratio outcome.

Results

Among the 3907 eligible patients, 972 (24.9%), 1996 (51.1%), and 939 (24.0%) were exposed to an ART regimen whose third active agent was an NNRTI, PI, or INSTI, respectively. The total follow-up time was 13 640.24 person-years. The weighted hazard ratio for the association between the third active class and CD4/CD8 ratio ≥1 was .56 (95% confidence interval [CI]: .48–.65) for patients exposed to NNRTI + 2 NRTIs and .41 (95% CI: .35–.47) for those exposed to PI + 2 NRTIs, compared with those exposed INSTI + 2 NRTIs.

Conclusions

For people treated for HIV, INSTI-based ART appears to be associated with a higher CD4/CD8 ratio than NNRTI and PI-based ART.
Incidence and oncological implication of adrenal incidentalomas in esophageal cancer patients
Authors: van Doesburg J R , Voeten D M , Kalff M C , van Berge Henegouwen M I , Jol S , van den Bergh J E , Engelsman A F , Gisbertz S S , Daams F
Published: February 2023

Adrenal incidentalomas are regularly encountered during imaging for esophageal cancer patients, but their oncological significance remains unknown. This study aimed to describe the incidence and etiology of adrenal incidentalomas observed throughout the diagnostic workup. This retrospective cohort study included all esophageal cancer patients referred to or diagnosed in the Amsterdam UMC between January 2012 and December 2016. Radiology and multidisciplinary team meeting reports were reviewed for adrenal incidentalomas. In case of adrenal incidentaloma, the 18FDG-PET/CT was reassessed by a radiologist blinded for the original report. In case of a metachronous incidentaloma during follow-up, visibility on previous imaging was reassessed. Primary outcome was the incidence, etiology and oncological consequence of synchronous adrenal incidentalomas. This study included 1,164 esophageal cancer patients, with a median age of 66 years. Patients were predominantly male (76.1%) and the majority had an adenocarcinoma (69.0%). Adrenal incidentalomas were documented in 138 patients (11.9%) during the diagnostic workup. At primary esophageal cancer workup, 22 incidentalomas proved malignant. However, follow-up showed that four incidentalomas were inaccurately diagnosed as benign and three malignant incidentalomas were visible on staging imaging but initially missed. Stage migration occurred in 15 of 22 (68.2%), but this would have been higher if none were missed or inaccurately diagnosed. The oncological impact of adrenal incidentalomas in patients with esophageal cancer is significant as a considerable part of incidentalomas changed treatment intent from curative to palliative. As stage migration is likely, pathological examination of a synchronous adrenal incidentaloma should be weighted in mind.
Creativity and Corporate Culture*
Authors: Charness Gary , Grieco Daniela
Published: February 2023

We investigate which form of corporate culture is most effective in enhancing individual performance in creative tasks conducted in group settings. We combine a series of experiments with a questionnaire on corporate values to test whether performance ranking and incentives succeed in instantiating a creative corporate culture. Being ranked against competitors and setting incentives at the group level serves as a social cue that appears to induce in members a significantly stronger pro-social attitude. When this attitude is shared by group members, a social norm of high effort emerges, and creative performance is significantly higher.
Treatment of infected hybrid arch prosthesis with self-assembled bovine elephant trunk grafts
Authors: Reineke David , Makaloski Vladimir , Schoenhoff Florian , Siepe Matthias
Published: February 2023

Graft infections are associated with severe morbidity and mortality. The widespread use of the frozen elephant technique increases the incidence of complex aortic patients to suffer from graft infections. Surgery of these patients is challenging. Removal of the stent graft portion of the frozen elephant technique prosthesis via sternotomy carries the risk of irreparable damage to the descending aorta. There is currently no single-stage surgical strategy that allows for the removal of all infected material apart from a hemi-clamshell approach. This approach is technically demanding and associated with significant morbidity and mortality. This results in conservative treatment in a substantial number of patients. Pericardial tube grafts have shown to be an excellent option in treating graft infections in various aortic segments with promising results concerning freedom of re-infection and survival. We report a single-stage, trans-sternal approach to remove all infected materials and simultaneously treat the descending aorta to prevent aortic catastrophe in 2 consecutive cases.
Overview of Cardiac Rehabilitation following post-acute myocardial infarction in European Society of Cardiology member countries
Authors: Ruivo Jorge , Moholdt Trine , Abreu Ana
Published: February 2023

Aims

Cardiovascular disease (CVD) is still a leading cause of death and morbidity in Europe and must be addressed through approaches beyond therapeutic interventions and pharmacological management. Cardiac rehabilitation (CR) is a comprehensive, individualized, and patient-tailored programme, comprising multidisciplinary interventions. Despite its clinical benefits, cost-effectiveness, and existing guidelines, CR uptake in Europe remains suboptimal and detailed information on its current state is lacking. This centralized pan-European study (Overview of Cardiac Rehabilitation—OCRE) aimed to characterize and advance the knowledge about European Society of Cardiology (ESC) affiliated national CR settings.

Methods and results

An online survey about provision and quality indicators from CR was sent to the network of National CVD Prevention Coordinators of ESC member states, whose answers were supported by published evidence and/or national experts. The OCRE study had a high participation rate (82%). Current positive aspects of CR include low dropout rates and short average start time after myocardial infarction, as well as public funding being standard practice. However, the uptake rate and average duration of CR are still suboptimal, and several countries lack CR mandatory rotation in Cardiology training, guidance documents, national accreditation, and electronic database registries. We also found several barriers to CR guideline implementation, at patient, staff, and healthcare levels.

Conclusions

This study provides a comprehensive characterization of CR in Europe, generating important insight on the current provision and quality of CR in Europe, highlighting its sucesses and shortcomings, and discussing important strategies to overcome current obstacles.
Primary care professionals’ views on population-based expanded carrier screening: an online focus group study
Authors: van den Heuvel Lieke M , Woudstra Anke J , van der Hout Sanne , Jans Suze , Wiersma Tjerk , Dondorp Wybo , Birnie Erwin , Lakeman Phillis , Henneman Lidewij , Plantinga Mirjam , van Langen Irene M
Published: February 2023

Background

Population-based expanded carrier screening (ECS) involves screening for multiple recessive diseases offered to all couples considering a pregnancy or during pregnancy. Previous research indicates that in some countries primary care professionals are perceived as suitable providers for ECS. However, little is known about their perspectives. We therefore aimed to explore primary care professionals’ views on population-based ECS.

Methods

Four online focus groups with 14 general practitioners (GPs) and 16 community midwives were conducted in the Netherlands.

Results

Our findings highlight various perspectives on the desirability of population-based ECS. Participants agreed that ECS could enhance reproductive autonomy and thereby prevent suffering of the child and/or parents. However, they also raised several ethical, societal, and psychological concerns, including a tendency towards a perfect society, stigmatization, unequal access to screening and negative psychosocial consequences. Participants believed that provision of population-based ECS would be feasible if prerequisites regarding training and reimbursement for providers would be fulfilled. most GPs considered themselves less suitable or capable of providing ECS, in contrast to midwives who did consider themselves suitable. Nevertheless, participants believed that, if implemented, ECS should be offered in primary care or by public health services rather than as hospital-based specialized care, because they believed a primary care ECS offer increases access in terms of time and location.

Conclusions

While participants believed that an ECS offer would be feasible, they questioned its desirability and priority. Studies on the desirability and feasibility of population-based ECS offered in primary care or public health settings are needed.
Job Quality and Job Separation of Direct Care Workers in England
Authors: Vadean Florin , Saloniki Eirini-Christina
Published: February 2023

Background and Objectives

Most job leavers in the long-term care (LTC) sector in England do not leave the sector, but rather move to other LTC employers. Nevertheless, the high “churn” can have a negative impact on continuity and quality of care, care providers’ recruitment and training costs, and the remaining staff workload and motivation. This study aimed to provide quantitative evidence on the drivers of direct care workers’ job separation in England, with a focus on job quality.

Research Design and Methods

We used yearly data (2016–19) from the Adult Social Care Workforce Data Set, the leading source of LTC workforce data in England, including information on both LTC workers and employers. The analysis considered panel data econometric methods that accounted for unobserved heterogeneity at worker and employer levels.

Results

After controlling for observed individual, organizational, and local market characteristics as well as unobserved worker and employer heterogeneity, we found that everything else being equal, wages and employment conditions (i.e., full-time contracts and contracts with guaranteed working hours) significantly reduce job separation. For example, a 10% wage increase from the sample mean would reduce the job separation rate by about 3 percentage points. This wage effect was more than halved (i.e., downward biased) when not accounting for unobserved effects.

Discussion and Implications

The persistent high staff turnover in LTC in England highlights the need for finding practical solutions faced by care providers and policy-makers. Our findings showed that improving pay and employment conditions can be the way forward while methodologically stressing the importance of accounting for unobserved variable bias.
Classification of transient triggering mechanisms of aftershocks in the post-seismic phase of the 2017 Pohang earthquake, South Korea
Authors: Lee Sungho , Woo Jeong-Ung , Rhie Junkee
Published: February 2023

The 2017 Mw 5.5 Pohang earthquake occurred near an enhanced geothermal system site and generated thousands of aftershocks, the largest of which, a Mw 4.6 earthquake, occurred 87 d after the mainshock. Redistribution of the groundwater pressure perturbed by the mainshock has been suggested as a cause of the post-seismic stress changes triggering several aftershocks, including the time-delayed event. However, to date, possible effects of variations in pore pressure on the aftershock occurrence have not been quantified in this region. Therefore, we conducted poroelastic modelling to evaluate this contribution to spatiotemporal distribution of the aftershocks, including the delayed event, using a fully coupled hydromechanical code. To construct a poroelastic model, a segmented fault geometry and a layered lithological structure were used. In addition, we utilized a kinematic slip model, a split-node algorithm and in-situ properties to simulate reliable coseismic and post-seismic behaviour. Our reference model successfully reproduced coseismic surface deformation in a line-of-sight direction, comparable to the corresponding observation from interferometric synthetic aperture radar, and was calibrated using groundwater measurement in a well. In addition to constructing the reference model, a series of numerical simulations were conducted to explore the effects and sensitivities of various hydraulic conductivities. Finally, the modelled Coulomb stress changes and spatiotemporal distribution of the aftershocks were analysed to elucidate the transient triggering mechanisms based on conditional statements to classify the mechanisms into several subsets. The classification showed that the poroelastic effect driven by depth/conductivity-dependent fluid diffusion is more critical to aftershock occurrence than the diffusion in the entire simulation time, and we propose that the delayed earthquake of Mw 4.6 could be correlated with poroelastic triggering rather than diffusion triggering. Furthermore, we inferred that this poroelastic effect could contribute to decay of aftershocks, particularly relatively small-magnitude aftershocks, as well as slow this decay in bedrocks. However, the proposed model does not explain all of the observed aftershocks, and other driving forces or triggering mechanisms need to be considered.
Quantum mechanics-based seismic energy absorption analysis for hydrocarbon detection
Authors: Xue Ya-juan , Wang Xing-jian , Cao Jun-xing , Liu Zhe-ge , Yang Jia
Published: February 2023

Seismic attenuation has a considerable impact on resolution reduction and the increase in the dominant frequency period of seismic data. The absorption coefficient estimates, which measure inelastic attenuation, provide a deep understanding of the medium property changes in different geological settings. Conventional absorption coefficient estimation technologies always use time–frequency methods for seismic energy absorption analysis. However, despite continuing efforts to improve the absorption coefficient estimation, the limitation of the time–frequency methods still causes insufficient accuracy of the attenuation estimates, imposing major challenges in oil and gas hydrate exploration. In this study, a quantum mechanics-based seismic absorption coefficient estimation method was proposed for hydrocarbon detection. The seismic data were first projected on a specific basis constructed using the resolution of the Schrödinger equation. Seismic energy absorption analysis was then conducted in the potential-wave function domain. Finally, the quantum absorption coefficient estimates are given by the procedure after using a logarithmic operation and the least-squares fitting method. We examined the merits of these methods using model and field data. The gas reservoir was accurately targeted, which demonstrates that the proposed method has great potential for hydrocarbon detection.
Electromagnetic resolution—a CSEM study based on the Wisting oil field
Authors: Thorkildsen Vemund Stenbekk , Gelius Leiv-J
Published: February 2023

We consider marine controlled source electromagnetic (CSEM) data and demonstrate that a typical CSEM survey is associated with significant data redundancy. Thus, it should be possible to obtain a high-quality inversion result by using only a subset of the original data. Moreover, in survey design, effort should be made to optimize the placement of the receivers. This study therefore investigates the challenges of data decimation and survey design in the case of repeated surveys by use of the data resolution matrix and model resolution matrix. A framework of analysis has been developed to efficiently use these quantities. The feasibility of the proposed approach is demonstrated using both synthetic data computed from an interpreted model of the Wisting oil field in the Barents Sea, as well as actual field data from the same oil field.
O-fucosylation of thrombospondin type I repeats is dispensable for trafficking thrombospondin 1 to platelet secretory granules
Authors: Berardinelli Steven J , Sillato Andrew R , Grady Richard C , Neupane Sanjiv , Ito Atsuko , Haltiwanger Robert S , Holdener Bernadette C
Published: February 2023

Thrombospondin 1 (THBS1) is a secreted extracellular matrix glycoprotein that regulates a variety of cellular and physiological processes. THBS1’s diverse functions are attributed to interactions between the modular domains of THBS1 with an array of proteins found in the extracellular matrix. THBS1’s three Thrombospondin type 1 repeats (TSRs) are modified with O-linked glucose-fucose disaccharide and C-mannose. It is unknown whether these modifications impact trafficking and/or function of THBS1 in vivo. The O-fucose is added by Protein O-fucosyltransferase 2 (POFUT2) and is sequentially extended to the disaccharide by β3glucosyltransferase (B3GLCT). The C-mannose is added by one or more of four C-mannosyltransferases. O-fucosylation by POFUT2/B3GLCT in the endoplasmic reticulum has been proposed to play a role in quality control by locking TSR domains into their three-dimensional fold, allowing for proper secretion of many O-fucosylated substrates. Prior studies showed the siRNA knockdown of POFUT2 in HEK293T cells blocked secretion of TSRs 1–3 from THBS1. Here we demonstrated that secretion of THBS1 TSRs 1–3 was not reduced by CRISPR-Cas9-mediated knockout of POFUT2 in HEK293T cells and demonstrated that knockout of Pofut2 or B3glct in mice did not reduce the trafficking of endogenous THBS1 to secretory granules of platelets, a major source of THBS1. Additionally, we demonstrated that all three TSRs from platelet THBS1 were highly C-mannosylated, which has been shown to stabilize TSRs in vitro. Combined, these results suggested that POFUT2 substrates with TSRs that are also modified by C-mannose may be less susceptible to trafficking defects resulting from the loss of the glucose-fucose disaccharide.
Neuraminidase 4 (NEU4): new biological and physiological player
Authors: Okun Sarah , Peek Allyson , Igdoura Suleiman A
Published: February 2023

Sialidases are found in viruses, bacteria, fungi, avians, and mammals. Mammalian sialidases differ in their specificity, optimum pH, subcellular localization, and tissue expression. To date, four genes encoding mammalian sialidases (NEU1–4) have been cloned. This review examines the functional impact of NEU4 sialidase on complex physiological and cellular processes. The intracellular localization and trafficking of NEU4 and its potential target molecules are discussed along with its impact on cancer, lysosomal storage disease, and cellular differentiation. Modulation of NEU4 expression may be essential not only for the breakdown of sialylated glycoconjugates, but also in the activation or inactivation of functionally important cellular events.
Why do individuals create posts on organizations’ social media pages? Identifications, functions, and audiences beyond the organizational boundary for social change
Authors: Ihm Jennifer
Published: February 2023

Previous research has centered on nonprofit organizations’ (NPOs’) roles in developing relationships with the public and leading collective action. However, individuals may also create posts on NPOs’ social media pages to generate relationships with audiences other than the organization, and to self-mobilize connective action to reach their own goals. Based on content analysis of 576 actual posts and survey responses about them, this study suggests that posters with high organizational identification respond to the focal organizations, while those with high issue identification use the organizational context for their own purposes, disseminating information related to the focal issue to the general population or promoting the issue to their personal networks. This study extends discussions of ramifications of multiple identifications in the social media environment and captures the transformed relationships between organizations and individuals who create posts on NPOs’ social media pages and their new roles in connective action.
The need for public opinion and survey methodology research to embrace preregistration and replication, exemplified by a team’s failure to replicate their own findings on visual cues in grid-type questions
Authors: Lundmark Sebastian , Protzko John , Weissenbilder Marcus
Published: February 2023

Survey researchers take great care to measure respondents’ answers in an unbiased way; but, how successful are we as a field at remedying unintended and intended biases in our research? The validity of inferences drawn from studies has been found to be improved by the implementation of preregistration practices. Despite this, only 3 of the 83 published articles in POQ and IJPOR in 2020 feature explicitly stated preregistered hypotheses or analyses. This manuscript aims to show survey methodologists how preregistration and replication (where possible) are in service to the broader mission of survey methodology. To that end, we present a practical example of how unknown biases in analysis strategies without preregistration or replication inflate type I errors. In an initial data collection, our analysis showed that the visual layout of battery-type questions significantly decreased data quality. But after committing to replicating and preregistering the hypotheses and analysis plans, none of the results replicated successfully, despite keeping the procedure, sample provider, and analyses identical. This manuscript illustrates how preregistration and replication practices might, in the long term, likely help unburden the academic literature from follow-up publications relying on type I errors.
Utterly Unbelievable: The Discourse of ‘Fake’ SOGI Asylum Claims as a Form of Epistemic Injustice
Authors: Ferreira Nuno
Published: February 2023

Media and political debates on refugees and migration are dominated by a discourse of  ‘fake’ and ‘bogus’ asylum claims. This article explores how this discourse affects in acute ways those people claiming asylum on grounds of sexual orientation or gender identity (SOGI). In particular, the article shows how such a discourse of ‘fakeness’ goes far beyond the well-documented and often inadequate credibility assessments carried out by asylum authorities. By framing the analysis within the context of the scholarship on epistemic injustice, and by drawing on a large body of primary and secondary data, this article reveals how the discourse of ‘fake’ SOGI claims permeates the conduct not only of asylum adjudicators, but also of all other actors in the asylum system, including non-governmental organizations, support groups, legal representatives, and even asylum claimants and refugees themselves. Following from this theoretically informed exploration of primary data, the article concludes with the impossibility of determining the ‘truth’ in SOGI asylum cases, while also offering some guidance on means that can be employed to alleviate the epistemic injustice produced by the asylum system against SOGI asylum claimants and refugees.
Climatic Niche Conservatism and Ecological Diversification in the Holarctic Cold-Dwelling Butterfly GenusErebia
Authors: Klečková Irena , Klečka Jan , Fric Zdeněk Faltýnek , Česánek Martin , Dutoit Ludovic , Pellissier Loïc , Matos-Maraví Pável
Published: February 2023

The diversification of alpine species has been modulated by their climatic niches interacting with changing climatic conditions. The relative roles of climatic niche conservatism promoting geographical speciation and of climatic niche diversification are poorly understood in diverse temperate groups. Here, we investigate the climatic niche evolution in a species rich butterfly genus, Erebia (Dalman, 1816). This Holarctic cold-dwelling genus reaches the highest diversity in European mountains. We generated a nearly complete molecular phylogeny and modeled the climatic niche evolution using geo-referenced occurrence records. We reconstructed the evolution of the climatic niche and tested how the species’ climatic niche width changes across the occupied climate gradient and compared two main Erebia clades, the European and the Asian clade. We further explored climatic niche overlaps among species. Our analyses revealed that the evolution of Erebia has been shaped by climatic niche conservatism, supported by a strong phylogenetic signal and niche overlap in sister species, likely promoting allopatric speciation. The European and the Asian clades evolved their climatic niches toward different local optima. In addition, species in the European clade have narrower niches compared to the Asian clade. Contrasts among the clades may be related to regional climate differences, with lower climate seasonality in Europe compared to Central Asia favoring the evolution of narrower niches. Further, adaptive divergence could appear in other traits, such as habitat use, which can be reflected by narrower climatic niches detected in the European clade. Our study extends knowledge about the complexity of evolutionary drivers in temperate insects.
Use of a Synthetic Dermal Matrix for Reconstruction of 55 Patients with Nongraftable Wounds and Management of Complications
Authors: Concannon Elizabeth , Damkat-Thomas Lindsay , Rose Emma , Coghlan Patrick , Solanki Nicholas , Wagstaff Marcus
Published: February 2023

The aim of this study was to investigate the role of a completely synthetic dermal matrix (Biodegradable Temporizing Matrix [BTM]) for staged reconstruction of complex wounds. The authors defined complex wounds as wounds not amenable to reconstruction with skin grafting alone due to an inherent avascularity such as the presence of bare bone, tendinous, or neural structures. A retrospective review of a prospectively maintained database of complex wounds as defined above was carried out. Fifty-five patients were identified who underwent staged BTM and autologous skin graft reconstruction for complex wounds affecting a wide variety of patient demographics, treatment indications, and body sites. Wound etiology included burn injury and nonburn-related trauma such as degloving injury or infective complications. Caveats relating to the successful application of staged dermal matrix reconstruction, techniques, tips, prevention, and management of complications are outlined. This large consecutive case series demonstrates the integral role dermal substitutes play in providing biological wound cover for avascular wound beds which may otherwise require complex distant flap or free tissue transfer for reconstruction. Staged synthetic dermal matrix reconstruction has proven robustness in the face of unfavorable wounds compared with nonsynthetic dermal matrices, physiologically covering avascular structures, allowing for early graft take, expediting rehabilitation, and mobilization with good scar cosmesis and limited contracture formation.
Internal multiple suppression with convolutional neural network-based transfer learning
Authors: Liu Xiaozhou , Hu Tianyue , Liu Tao , Wei Zhefeng , Xiao Yanjun , Xie Fei , Duan Wensheng , Cui Yongfu , Peng Gengxin
Published: February 2023

Deep learning methods have been widely applied to seismic denoising, outperforming existing methods in efficiency and generalization. For internal multiple suppression, however, deep learning models face the challenge of low generalization owing to the variability of internal multiples. This diminishes the advantages of deep learning methods over current processing flows. To overcome this, we redesign a convolutional neural network (CNN) method in the aspect of label generation and training process to suppress internal multiples. We apply the virtual event (VE) method to a small amount of data and take removed internal multiple data as labels to accelerate the network training, which is multiple learning. Instead of training a pervasive model to apply to all datasets, we rely on transfer learning to generalize. We finetune the synthetic data training model on target datasets to obtain the model applicable to the dataset with a low requirement of training data and time. Tests on synthetic and field data demonstrate the effects of multiple learning and transfer learning, as well as the competitive demultipling performance of our method compared with both the VE method and the original CNN in efficiency and primary-preserving ability.
Reconciling reports: modelling employment earnings and measurement errors using linked survey and administrative data
Authors: Jenkins Stephen P , Rios-Avila Fernando
Published: February 2023

We develop and apply new statistical models for linked survey and administrative data on employment earnings, incorporating 4 types of measurement error. In addition, we allow error distributions to differ with individual characteristics, which improves model fit and allows us to investigate substantive hypotheses about factors associated with error bias and variance. Contributing the first UK evidence to a field dominated by findings about the USA, we show that measurement errors are pervasive, but the 4 types are quite different in nature. We also document substantial heterogeneity in each of the error distributions.
Use of Veterans Health Administration Structured Data to Identify Patients Eligible for Lung Cancer Screening
Authors: Gundle Kenneth , Hooker Elizabeth R , Golden Sara E , Shull Sarah , Crothers Kristina , Melzer Anne C , Slatore Christopher G
Published: February 2023

Introduction

Lung cancer screening (LCS) uptake is low. Assessing patients’ cigarette pack-years and years since quitting is challenging given the lack of documentation in structured electronic health record data.

Materials and Methods

We used a convenience sample of patients with a chest CT scan in the Veterans Health Administration. We abstracted data on cigarette use from electronic health record notes to determine LCS eligibility based on the 2021 U.S. Preventive Services Task Force age and cigarette use eligibility criteria. We used these data as the “ground truth” of LCS eligibility to compare them with structured data regarding tobacco use and a COPD diagnosis. We calculated sensitivity and specificity as well as fast-and-frugal decision trees.

Results

For 50-80–year-old veterans identified as former or current tobacco users, we obtained 94% sensitivity and 47% specificity. For 50-80–year-old veterans identified as current tobacco users, we obtained 59% sensitivity and 79% specificity. Our fast-and-frugal decision tree that included a COPD diagnosis had a sensitivity of 69% and a specificity of 60%.

Conclusion

These results can help health care systems make their LCS outreach efforts more efficient and give administrators and researchers a simple method to estimate their number of possibly eligible patients.
Self consistent grain depletions and abundances II: Effects on strong-line diagnostics of extragalactic H ii regions
Authors: Gunasekera Chamani M , Ji Xihan , Chatzikos Marios , Yan Renbin , Ferland Gary
Published: February 2023

The depletion of elements onto dust grains is characterized using a generalized depletion strength F* for any sightline, and trend-line parameters AX, BX, and zX. The parameters AX, BX, and zX define the relative depletion pattern, for which values are published in previous works. The present study uses these parameters to calculate post-depleted gas-phase abundances of 15 different elements while varying F* from 0 to 1. An analysis of emergent strong spectral line intensities, obtained by inputting the calculated abundances into a cloudy model, shows that the depletion strength has a non-trivial effect on predicted emission lines and the thermal balance of the ionized cloud. The amount by which elements deplete also affects the coolant abundances in the gas. Furthermore, it was found that each of the parameters – metallicity, ionization parameter U, and depletion strength F* have degenerate effects on the emission-line strengths, and thermal balance of the interstellar medium (ISM). Finally, comparing our results to a sample of H ii regions using data obtained from the Mapping Nearby Galaxies at Apache Point Observatory survey (MaNGA) revealed that the best-fit F* was approximately 0.5. However, this best-fitting value does not work well for all metallicities. Removing the sulfur depletion and changing the nitrogen abundance pattern can improve the fit. As a result, extra observational evidence is required to verify the choices of parameters and better constrain the typical depletion strength in galaxies.
The frequency ratio and time delay of solar radio emissions with fundamental and harmonic components
Authors: Chen Xingyao , Kontar Eduard P , Clarkson Daniel L , Chrysaphi Nicolina
Published: February 2023

Solar radio bursts generated through the plasma emission mechanism produce radiation near the local plasma frequency (fundamental emission) and double the plasma frequency (harmonic). While the theoretical ratio of these two frequencies is close to 2, simultaneous observations give ratios ranging from 1.6 to 2, suggesting either a ratio different from 2, a delay of the fundamental emission, or both. To address this long-standing question, we conducted high-frequency, high-time resolution imaging spectroscopy of type III and type J bursts with fine structures for both the fundamental and harmonic components with LOFAR between 30 and 80 MHz. The short-lived and narrow frequency-band fine structures observed simultaneously at fundamental and harmonic frequencies give a frequency ratio of 1.66 and 1.73, similar to previous observations. However, frequency-time cross-correlations suggest a frequency ratio of 1.99 and 1.95 with a time delay between the F and H emissions of 1.00 and 1.67 s, respectively for each event. Hence, simultaneous frequency ratio measurements different from 2 are caused by the delay of the fundamental emission. Among the processes causing fundamental emission delays, anisotropic radio-wave scattering is dominant. Moreover, the levels of anisotropy and density fluctuations reproducing the delay of fundamental emissions are consistent with those required to simulate the source size and duration of fundamental emissions. Using these simulations we are able to, for the first time, provide quantitative estimates of the delay time of the fundamental emissions caused by radio-wave propagation effects at multiple frequencies, which can be used in future studies.