bluuebunny/crossref_metadata_2025 huggingface dataset:
Fear of Birth and Childbirth Preferences in BIPOC Women Prior to Childbirth Education
Authors: Carraher Sydnie , Allen Ruth , Alvarez Magda Elisa , Ford Amy
Published: January 2024

The purpose of this project was to examine a free tailored childbirth education (CBE) program’s impact on fear of childbirth and birth preferences in Black, Indigenous, and people of color women. Expectant mothers (N= 8) completed an investigator-designed questionnaire before attending a prenatal community-based CBE program. Post-CBE surveys were not analyzed due to participant data not matching the pre-CBE surveys. Survey results revealed that participants were highly educated and had low levels of fear. Qualitative data revealed common concerns including pain, wishes not being met, desire for a natural birth, and hope for healthy outcomes. Future research is needed to provide evidence that a free culturally matched CBE program is beneficial in high-risk perinatal populations.
Challenges In Cancer Immunotherapy
Authors: Jaiswal Rishi Kumar
Published: January 2024

The concept of deploying the immune system to treat neoplastic diseases emerged in the nineteenth century. It made significant progress in the twentieth century with the advent of new technology. Various immunotherapy treatments exist, including cancer vaccines, monoclonal antibodies, cytokines, adjuvants, tumor-infecting viruses, and adoptive immunotherapy. The different types and approaches of immunotherapy have revolutionized the field of oncology by increasing the survival of patients with fatal cancers. Despite these advances, there are still many obstacles in immunotherapy. This review will discuss the challenges in immunotherapy, including the need for more predictive biomarkers, tumor heterogeneity, and resistance to drugs.
Inefficiencies in Prescribing Medications are Contributing to Physician and Staff Burnout
Authors: Dunham Daniel P
Published: January 2024

Physician burnout has been increasing over the past decade. This phenomenon is found throughout the world and has many etiologies. Some of these are easily identified and treated. Of the remedial causes, improved practice efficiency is one that is getting increased attention. Time spent directly with patients is and will always be a core component of health care. Physician time spent away from direct patient care should be identified and minimized. In the future, provider communication with patients will likely increasingly take place outside of the physician office. These interactions will almost certainly continue to result in the need to prescribe medications. Despite the potential technologic advances to facilitate this process, there is considerable frustration for both providers and patients with the increased use of technology in the prescription of medications. There are multiple reasons for these frustrations, including more complicated prior authorization processes, larger and more inaccurate medication lists, automated processes in which physicians are involved with every prescription refill, and difficulty in cancelling prescriptions. If these inefficiencies can be minimized, improvements such as decreased provider and staff turnover, better patient outcomes and lower overall health care costs can be attained.
Development and Evaluation of Microballons Based Extended Release Drug Delivery System for Hypertension Therapy
Authors: 10.19080/GJPPS.2019.06.555718Bangale Ganesh S
Published: January 2024

The objective of the present work was to formulate and evaluate micro balloons of Captopril to for prolongation of gastric residence time. The micro balloons were prepared by the solvent diffusion technique using different ratio of Ethyl cellulose, HPMCK4M & acrylic polymers as Eudragit RL100. Micro balloons characterized for micrometrics properties found in passable to good range, the yield of micro balloons was up to 71.20 ±4.68 to 92.25 ±2.34 % and % entrapment efficiency was found to be 71.40±1.64 to 87.34±2.54% respectively. The size of micro balloons formulations was in the range of 159.1±4.09 to 203.42±5.61. The shape and surface morphology of prepared micro balloons were characterized by scanning electron microscopy. The micro balloons formed were additionally found to be floating over gastric juice for > 12 hours. A broad range of drug release pattern could be achieved by varying the drug and polymer amount, the best results were obtained in F-4 formulation at the ratio of drug: polymer (1:1) containing HPMC K4M and Eudragit RL100 as a polymer exhibited prolong drug release over 12 hrs. Higher values of correlation coefficients were obtained with Higuchi’s square root of time kinetic. The mechanism of the release of Captopril from formulation was found to be Non-fickian transport. Drug–Polymers interaction has been determined based on FTIR studies. Optimized formulation (F-4) was stable up to 90 days prior storage at 40±20C & 5-8±20C in terms of % yield, %E.E. & % drug released. Non-significant difference was observed in above analyzed parameters, supported by t crit > t stat by t test with p =0.05. The developed Floating micro balloons of Captopril might be clinically used for prolonged drug release in GIT, for better drug utilization and improved patient compliance.
Heralding the Drug Related Problems by Using Hepler-Strand Classification in a Tertiary Care Teaching Hospital
Authors: Reddy YV Manohar
Published: January 2024

Drug related problems (DRP) are generally referred as “an event (or) circumstance involving in drug treatment at all stages from prescribing to dispensing, which interferes actually or potentially with the patient achieving an outcome of pharmaceutical care. Various classifications were involved in drug related problems among which Hepler–Strand classification is widely followed. This study aimed to identify and report the drug related problems by using Hepler-strand classification and to educate the patients regarding safe use of medications. This is a Prospective observational study which was conducted over a period of 6 months in inpatient wards of General Medicine, Pediatrics and General Surgery at Sri Venkateswara Ramnarayan Ruia Government General hospital. A total of 150 patients were analysed during the study period. Among them76 (50.7%) were male and 74 (49.3%) were female patients. Among 150 prescriptions majority were found with DRP’s 89 (59.4%) followed by prescriptions without DRP’s was 61 (40.6%). Within 89 prescriptions a total of 277 DRP’s were observed. It includes 107 DRP’s in surgery; followed by 131 DRP’s in general medicine and 39 DRP’s in paediatrics. In a total of 277 DRP’s drug interactions was found to be in 264 cases, ADR’s in 4 cases, others in 9 cases. In those 264 drug interactions, drug-drug interactions (205), followed by drug-food interactions (59) were observed. The involvement of the clinical pharmacist may also improve the better usage of drugs in hospital and to decrease the economic status of patient.
In Vitro Antibacterial Effect of Four Medicinal Plant Extracts on Brucella Abortus Isolated from Cattle
Authors: Ali Mai Abdalla
Published: January 2024

Background: Brucella abortus is the main causative agent of an infectious zoonotic disease known as brucellosis in both human and livestock. The most commonly used vaccine, B. abortus S99 for brucellosis has often given false positive results in mature animals which has brought a high risk for the bacteria vaccine to humans, thus the option for new antibacterial compounds are becoming necessary for efficient brucellosis treatment. This study aimed to investigate the antibacterial activity of extracts of Lepidium sativum, Solenostemma argel, Organum marjoram and Eucalyptus camaldulensis. Methodology: Aqueous, hexane and alcohol extracts of Lepidium sativum, Solenostemma argel, Origanum marjoram and Eucalyptus camaldulensis were used to determine the antibacterial activity using well diffusion test; inoculation broth method and disc diffusion method at different concentrations, using Streptomycin as a positive control. Results: The results obtained showed different inhibition zones with different herbs, Lepidium sativum (46mm/20%/ hexane extract /well test), Solenostemma argel (36mm /20%/hexane extract /disc test) and Marjoram origanum (20 mm /20%/ethanol , hexane extracts /well test). No inhibition was observed in case of Eucalyptus camaldulensis extracts. Streptomycin reached inhibition (56mm) in Lepidium sativum hexane extract dish;(56mm) in the Solenostemma argel ethanol extract dish and extract (52mm) in the Marjoram origanum ethanol extract.
Development and Validation of a Novel Analytical Method for the Determination of Dissolution Rate of Acetylsalicylic Acid in Enteric-Coated Tablet Dosage Form by Liquid Chromatography
Authors: Akdemir Emine
Published: January 2024

Objective: The aim of this study is to determine the applicability of UV detection method by the sensitive, simply, precise, specific, and low-cost High-Performance Liquid Chromatography (UHPLC) for acetylsalicylic acid in presence of its degradation product. Methods: Method development and determination of dissolution rate for acetylsalicylic acid, were achieved by using reversed-phase liquid chromatography with PDA (Photodiode Array Detector) and TUV (Tunable UV Detector) detection by HCLASS-UHPLC. The new proposed method utilized by the Waters Acquity UHPLC® TUV and PDA systems using a UHPLC column Waters Acquity, BEH, C18, 2.1mm x 50mm, 1.7μm particle size with a mixture of heptane-1-sulphonic acid sodium salt solution which was prepared in acetonitrile: deionized water (15%: 85% v/v) in isocritic mode at a flow rate of 0.5ml/ min, at 25°C with a load of 5μL. The detection for all eluted compounds was carried out at 280nm.
Multiple Intraarticular Osteochondromas of the Knee
Authors: Firoozabadi M Ayati
Published: January 2024

Osteochondroma is the most common benign growing bone tumor that usually affects the knee joint area. It often involves the long bone metaphysis, which occurs extraarticularly. Despite this, single intraarticular osteochondroma is rarely reported in the literature, but multiple knee osteochondromas is very rare and has not been reported so far. The patient who is introduced is a 30-year-old woman who has undergone two arthrotomy surgeries of the left knee, in which intraarticular osteochondroma was reported in the pathology. In the second operation, due to the size of the lesion and the involvement of the patella, the surgeon had to perform a patellectomy. The patient was referred with severe knee pain and inability to flexion and extension the knee and was unable to walk without a walker. Due to severe osteoarthritis and lack of extensor mechanism and condition of multiple intraarticular osteochondromas of the knee, complete excision of multiple osteochondroma lesions was performed for the patient and Rotating Hinge Knee (RHK) prosthesis was implanted. During two years of treatment follow-up, there is no recurrence of the lesion and the patient walks without a walker and is able to flex the knee 100 degrees. Her knee pain was also relieved.
¡No hay nada que bailar!: Contracultura, cine musical clásico de Hollywood y ópera rock
Authors: Fuentes Ressine , Guerrero Berenice , Montalván Ruby , Shimabukuro Álvaro , Silva Mateo
Published: January 2024

En el presente artículo se analizan las películas “Jesus Christ Superstar” (Jewison, 1973), “Tommy” (Russell, 1975) y “Pink Floyd: The wall” (Parker, 1982), inspiradas en discos de ópera rock, para demostrar si presentan características que se alejan de los elementos tradicionales presentes en el cine musical clásico de Hollywood, como pueden apreciarse en las películas “Top hat” (Sandrich, 1935) y “Singin’ in the rain” (Donen y Kelly, 1952). Tras la interpretación respectiva, se detectan hallazgos de una rebelión contra lo tradicional desde la arremetida de las películas inspiradas en las óperas rock.
Laporan Kasus: Penanganan Flu Kucing akibat Feline Herpesvirus pada Kucing Kampung
Authors: Tama Kevin Tri , Soma I Gede , Batan I Wayan , Nurahyani Ni Putu Wirsa
Published: January 2024

Feline Herpesvirus tipe 1 (FHV-1) adalah agen penyebab penyakit saluran pernapasan yang menyebabkan rhinitis dan konjungtivitis. Seekor kucing kampung betina berumur 14 bulan dengan bobot 2,01 kg diperiksa dengan keluhan tidak makan selama tiga hari, lemas, dan sering bersin. Pemeriksaan fisik menunjukkan leleran pada kedua mata dan hidung, konjungtiva merah, dan mata buram atau cloudy. Pemeriksaan penunjang dengan tes cepat antigen FHV dan Calicivirus menunjukkan kucing kasus positif FHV. Hasil pemeriksaan hematologi menunjukkan kucing kasus mengalami anemia normositik normokromik dan leukositosis. Hewan didiagnosis menderita flu kucing akibat FHV tipe 1 dengan prognosis fausta. Terapi yang diberikan adalah terapi suportif dengan menjaga hidrasi, nebulasi salbutamol (100 g/ekor) dan gentamisin (8 mg/kg BB) satu kali sehari, L- lysine (500 mg/ekor) dua pompa (2 kali sehari), bromhexin HCl (1 mg/kg BB) secara per oral (2 kali sehari) selama tujuh hari, salep mata framixin satu tetes (2 kali sehari) selama tujuh hari, antibiotik doksisiklin (10 mg/kg BB) per oral (2 kali sehari) selama 14 hari, trimethoprim/sulfonamide (30 mg/kg BB) intramuskuler (sekali setiap 2 hari) selama 12 hari, dan intrafer 𝐵12 (0,02 mg/kg BB) secara intramuskuler di hari ketiga dan kesembilan. Hasil pengobatan selama 12 hari menunjukkan terjadi perubahan leleran kedua mata dan hidung serta frekuensi bersin yang berkurang. Hasil pemeriksaan darah dan mukosa mulut kembali normal.
Analisis erosi menggunakan USLE pada area disposal dan sekatan Sump Angsana Pit Tutupan PT Adaro Indonesia
Authors: Inhazama Tyas Ana , Mustofa Adip , Syafi'i Ahmad Ali
Published: January 2024

Erosi merupakan kehilangan atau terkikisnya tanah atau bagian tanah dari suatu tempat oleh air atau angin. Erosi menyebabkan hilangnya lapisan tanah yang subur dan baik untuk pertumbuhan tanaman serta berkurangnya kemampuan tanah untuk menyerap dan menahan air. Pengangkutan erosi yang terjadi di daerah iklim basah pada umumnya adalah pengangkutan erosi oleh air. Pengaruh iklim terhadap muka bumi serta segenap isinya, bukan saja besar, tetapi amat mendasar. Menurut pernyataan tersebut dapat diketahui bahwa berbagai variable yang mempengaruhi prediksi erosi berperan sangat penting dalam nilai erosi yang terjadi termasuk jenis tanah, vegetasi, dan panjang serta kemiringan lereng. Dari Hasil Perhitungan dan analisis pada area disposal laju erosi adalah sebesar 271 ton/ha/th yang dimana kehilangan tanah termasuk pada 180-480 dengan tingkat bahaya erosi tersebut jika dikorelasikan dengan tabel klasifikasi menurut departemen kehutanan 1998 dapat diketahui Tingkat bahaya erosi pada area disposal menunjukan Tingkat Bahaya Erosi Berat. Pada area sekatan laju erosi adalah sebesar 64 ton/ha/th dimana kehilangan tanah termasuk pada 16-60 dengan tingkat bahaya erosi tersebut jika dikorelasikan dengan tabel klasifikasi menurut departemen kehutanan 1998 dapat diketahui Tingkat bahaya erosi pada area sekatan menunjukan Tingkat Bahaya Erosi Sedang.
Optimasi blending batubara untuk meningkatkan kualitas dan memenuhi target market PT Multi Tambangjaya Utama
Authors: Kholis Nur , Santoso Eko , Novianti Yuniar Siska
Published: January 2024

Dalam operasionalnya, penting untuk memahami kualitas batubara sebelum melakukan kegiatan blending, karena kualitas batubara menjadi faktor kunci dalam pengambilan keputusan terkait blending tersebut. PT Multi Tambangjaya Utama memiliki lima kualitas batubara berbeda, terdiri dari Hijau Kananai, Merah Kananai, Kuning Kananai sebagai kualitas tinggi, serta Biru Kananai dan Abu-abu Kananai sebagai kualitas rendah. Untuk memperoleh data kualitas batubara selama proses produksi, dilakukan kegiatan blending dengan memperhatikan parameter seperti Ash, Total Moisture (TM), Total Sulfur (TS), dan Calorific Value (CV). Penelitian dilakukan untuk menentukan perbandingan yang optimal antara batubara kualitas rendah dan tinggi agar hasil blending sesuai dengan target pasar. Pengambilan sampel batubara dilakukan langsung di lapangan dan diuji laboratorium untuk mendapatkan data TM, TS, Ash, dan CV. Hasil uji laboratorium digunakan dalam analisis data untuk menentukan proporsi perbandingan pencampuran batubara berbeda kualitas. Berdasarkan analisis, perbandingan yang tepat untuk blending batubara adalah Kananai Merah (23%), Kananai Kuning (38%), Kananai Hijau (29%), Kananai Biru (7%), dan Kananai Abu-abu (2%), dengan berat aktual 94.917,71 ton (100%). Rencana produksi batubara dan blending akan didasarkan pada perbandingan ini untuk mencapai kualitas yang diinginkan.
Analisis material PAF dan NAF dengan metode NAG pada disposal M1E di PT Jorong Barutama Greston
Authors: Panjaitan Dimpos Romario , Saismana Uyu , Dwiatmoko Marselinus Untung
Published: January 2024

Penambangan Terbuka ialah salah satu metode penambangan yang sangat umum dijumpai di Indonesia, terutama pada industri penambangan batubara. Tanpa terkecuali, industri penambangan batubara tentunya memiliki beberapa dampak bagi lingkungan sekitarnya, dimana salah satunya ialah Air Asam Tambang yang terbentuk oleh tersingkapnya lapisan tanah penutup (overburden). Air asam tambang dapat terbentuk saat material yang berpotensi menyebabkan asam (material PAF) terkena paparan air serta udara. Pada disposal M1E di PT Jorong Barutama Greston telah dilakukan pengeboran guna pengambilan sampel untuk dianalisa dengan metode NAG. Dengan metode pengeboran full coring 6 titik bor, didapati 51 kantong sampel untuk dianalisis. Didapati bahwa 36 (70,59%) sampel tergolong PAF, tiga (5,88%) sampel tergolong NAF, dan 12 (23,53%) sampel tergolong PAF LC. Dengan stratigrafi batuan yang acak dikarenakan kurang adanya pengelolaan disposal yang baik, maka sangat besar potensi batuan PAF untuk mengkontaminasi batuan NAF oleh rembesan air hujan. Disposal M1E kemungkinan besar tergolong dalam disposal yang tidak ramah lingkungan, dimana air lindian yang keluar dari disposal tersebut akan cenderung bersifat asam. Untuk itu perlu dilakukan penelitian lanjutan terhadap disposal M1E guna pengumpulan data lebih lengkap.
Consolidación de un modelo palaciego basado en la domus vitruviana: del Palazzo dei Tribunali de Roma al Palazzo Te de Mantua = The consolidation of a palatial model based on the Vitruvian domus: From the Palazzo dei Tribunali in Rome to the Palazzo Te in Mantua
Authors: Gómez Gil Antonio Miguel , Mestre Martí María
Published: January 2024

AbstractThe article highlights that the free-standing palaces of the late Italian Renaissance, built by archi­tects of Bramante’s circle, share the same compositional scheme in plan, based on the study of the Vitruvian domus. Starting with the Palace of the Chancellery in Rome, the private palaces’ typology was consolidated during the 16th century. It consists of the articulation of the floor plan throughout two orthogonal axes: a main one clearly inspired by the longitudinal axis of the classical domus and an added second transverse axis, which joins two new and secondary accesses. This spatial organization generates a building divided into four almost autonomous parts, endowed with their own communication elements. Although articulated by a central cortile, it allows independent func­tioning. This typological model should be considered as one of the taxonomies that have so far not been highlighted in the Italian Mannerist architecture of Bramante’s circle.  ResumenEl artículo demuestra que los palacios exentos, del Bajo Renacimiento italiano, ejecutados por ar­quitectos del círculo de Bramante, comparten un mismo esquema compositivo en planta, basado en el estudio de la domus vitruviana. A partir del Palazzo della Cancelleria en Roma, la tipología del palacio privado se va consolidando durante el siglo XVI. Esta consiste en la articulación de la planta mediante dos ejes ortogonales: uno principal, claramente inspirado en el eje longitudinal de la domus clásica y un añadido segundo eje transversal, que une dos accesos nuevos y secun­darios. Dicha organización espacial genera un edificio dividido en cuatro partes casi autónomas, dotadas de elementos de comunicación propios, que, aunque articuladas por un cortile central, posibilitarían un funcionamiento independiente. Este modelo tipológico debe considerarse como una de las taxonomías no puestas en valor hasta ahora en la arquitectura manierista italiana del círculo de Bramante.
Célula y repetición: experiencias en la arquitectura española (1950-1980) = Cell and repetition: Experiences in Spanish Architecture (1950-1980)
Authors: Merino Benito Manuel
Published: January 2024

AbstractRepetition is one of the most powerful and frequent mechanisms used in architecture. Although always present, with notable appearances in the Beaux Arts school and especially in industrial buildings and in the Modern Movement, it is from the second half of the 20th century when architects begin to work with repetitive solutions in a more decisive and conscious way with basic units combined with each other. This article aims to classify and order, in a first approximation, Spanish architectural projects, carried out between the years 1950 and 1980, which have used the repetition of modules or cells as the main project tool. With this, an attempt has been made to understand the processes and rules underlying these systems, through comparative analyzes between the selected examples.ResumenLa repetición es uno de los mecanismos más poderosos y frecuentes empleados en arquitectura. Si bien siempre presente, con señaladas apariciones en la escuela de Beaux Arts y sobre todo en las edificiaciones industriales y en el Movimiento Moderno en general, es a partir de la segunda mitad del siglo XX cuando los arquitectos comienzan a trabajar con soluciones repetitivas de forma más decidida y consciente a partir de unidades básicas combinadas entre sí. Este artículo tiene como objetivo clasificar y ordenar en una primera aproximación proyectos de arquitectura española, realizados entre los años 1950 y 1980, que han empleado la repetición de módulos o células como principal herramienta proyectual. Con ello se han tratado de entender los procesos y reglas sub­yacentes a estos sistemas, por medio de análisis comparativos entre los ejemplos seleccionados.
Sobre viajes y componentes: incursiones de Osamu Ishiyama en el ensamblaje de la vivienda = On Trips and Components: Osamu Ishiyama’s Forays into House Assembly
Authors: Prieto Castro Salvador
Published: January 2024

AbstractIn 1986, the Japanese architect Osamu Ishiyama published the book Warau Jūtaku (Laughing House), where he humorously aimed to demonstrate that the houses he designed could be built for less than the average price of a typical house at that time. A decade prior, following the advice of his teacher Kenji Kawai, he embarked on a series of trips to the United States, which eventually led to the production of a series of houses through his company Dam Dan. Ishiyama capitalized on the price difference in building materials by industrializing an assembly process through the importation of containers from North America. These experiences in the realm of assembly laid the foundation for what Ishiyama called Akihabara kankaku (Akihabara Sensibility). Inspired by the Akihabara market, the architect envisioned the home as a self-constructed artifact made from readily available components.  ResumenEn 1986 el arquitecto japonés Osamu Ishiyama publicó el libro Warau Jūtaku (Casa de la risa), en el que de una forma jocosa pretendía demostrar que las viviendas que diseñaba podían construirse por debajo del precio medio de una casa típica de la época. Una década antes, aconsejado por su maestro Kenji Kawai, comenzaba un ciclo de viajes a Estados Unidos que desembocarían en la producción de una serie de viviendas con su compañía Dam Dan. Ishiyama aprovechó la diferencia de precio de los materiales de construcción para industrializar un proceso de ensamblaje a través de la importación de contenedores desde Norte América. Estas incursiones en el mundo del ensamblaje cimentaron la idea de Ishiyama en torno a lo que llamó Akihabara kankaku (Sensibilidad Akihabara). El mercado de Akihabara inspiró la idea del arquitecto, de que la vivienda debía ser un artefacto autoconstruido a partir de componentes de fácil adquisición.
Grape berry native yeast microbiota: advancing trends in the development of sustainable vineyard pathogen biocontrol strategies
Authors: Ayogu Peter , Martins Viviana , Gerós Hernâni
Published: January 2024

Grape berry is an ecological niche for a myriad of microbes, whose interactions with one another modulate fruit health and can play a role in fermentation, imparting character and distinctiveness to wines. With the growing concerns about and awareness of the risks associated with the overuse of chemical pesticides in viticulture, microbial-based pest control is increasingly encouraged as a more sustainable and environmentally friendly strategy. The use of yeasts from grape berries is a promising alternative for the control of vineyard diseases and their increasing acceptance is rapidly changing our perception of fungicides. In this paper, we provide an overview of the latest methodologies for characterising the dynamics of grape berry yeasts in the context of grape disease management, and discuss the prospects for their effective use as biocontrol agents in viticulture. Most research has focused on the control of fruit rots produced by Botrytis, Aspergillus, Colletotrichum and Penicillium spp. using formulations that comprise single strains of specific yeast genera, including Aureobasidium, Metschnikowia, Saccharomyces, Pichia, Candida and Rhodotorula. However, the challenging disparity between successful biocontrol outcomes obtained in vitro and their low applicability in the field is a major limitation for the large-scale implementation of these strategies. Novel research approaches for maximising the stability and efficiency of yeast-derived bioactives are discussed in this review.
From Questionable Incident to Political Scandal
Authors: Eder Maximilian
Published: January 2024

Political scandals have become an everyday phenomenon, among other things, due to the crucial role of social media platforms as they shape how scandals unfold, are reported upon by journalists, and are perceived by the audience. This article examines the process of scandalization and journalistic discourse on Twitter in Germany and Austria against the background of the so-called Ibiza affair. Through a critical discourse analysis of 885 tweets from 149 influential political journalists, this study seeks to add to the understanding of scandalization on Twitter. Building upon the functional phase model by Burkhardt (2015, 2018), the study finds that those previously identified phases of a (political) scandal in print media coverage are shortened on Twitter, indicating a different scandalization dynamic on social media.
Meming up the Scandals
Authors: Bebić Domagoj , Boko Antea , Dolinar Daniela
Published: January 2024

This research investigates the amplifying role of memes in political scandals. This study, therefore, begins with the hypothesis that political scandals originating from mainstream media extend to social networks through memes. Consequently, the duration and impact of a specific scandal are extended as it circulates within these online platforms. The case study examines three Croatian news portals – Večernji.hr, Index.hr, and Slobodnadalmacija.hr – and analyzes memes published on the Megatroll Split Facebook page in June 2022. Findings indicate that despite a smaller number of memes generated within a two-day timeframe, the Megatroll Split Facebook page received more user engagement than Večernji. hr, which published sixteen articles over eight days. This research confirms the significant role of memes in political scandals and underscores the need for further exploration in this area.
Basic Analytical Assumptions of Empowering the Periphery
Authors: Nakarada Radmila , Vidojević Jelena
Published: January 2024

Against the background of the global crises and the urgency it created, the authors attempt to problematise the pathways to empowering the peripheries of the world – the victimised, excluded, humiliated and entangled. As assumptions relevant for the empowerment of the peripheries they discuss: the need to re-read one’s own history; “accurate reconnaissance” of the current local circumstances; understanding the “workings of the global neoliberal capitalism”; focusing on integrating, making use of new scientific insights, reinvigorating fundamental values and generating internal actors of change; establishing new transformative alliances of the peripheries. The assumptions are contextualized in relation to the process of transition taking place in post-apartheid South Africa and post-socialist Serbia.
Charting Excellence in Healthcare: An In-Depth Exploration of Strategic Performance Metrics via Balanced Scorecard Implementation
Authors: Marques Paula , Oliveira Paulo
Published: January 2024

This study analyzes the convergence between artificial intelligence (AI) and management accounting in hospital contexts. Management accounting plays a central role in the effectiveness of planning, control and decision-making in healthcare institutions such as hospitals. The application of AI in this scenario offers powerful tools to improve accounting processes, optimize operational efficiency and maximize the use of available resources, resulting in an improvement in the quality of care provided to patients. Through in-depth analysis, the article explores how AI is bringing about a revolution in hospital management accounting, presenting case studies illustrating its successful implementation, outlining the tangible benefits.
Comparison of Different Machine Learning Methods to Reconstruct Daily Evapotranspiration Estimated by Thermal-Infrared Remote Sensing
Authors: Zhao Gengle , Song Lisheng , Zhao Long , Tao Sinuo
Published: January 2024

Remote sensing-based models usually have difficulty in generating spatio-temporally continuous terrestrial evapotranspiration (ET) due to cloud cover and model failures. To overcome this problem, machine learning methods have been widely used to reconstruct ET. However, studies comparing and evaluating the accuracy and effectiveness of reconstruction among different machine learning methods remain scarce. In this study, four popular machine learning methods (deep forest, deep neural network, random forest, extreme gradient boosting) were used to reconstruct the ET product, addressing gaps resulting from cloud cover and model failure. The ET reconstructed by four methods were evaluated and compared in Heihe River Basin. The results showed that four methods performed well in the Heihe River Basin, but the RF method was particularly robust. It not only performed well compared with ground measurement (R = 0.73), but also reconstructed ET throughout the basin. Validation based on ground measurement showed that DNN and XGB models performed well (R > 0.70). However, few gaps still existed in the desert after reconstruction, especially for the XGB model. The DF model filled these gaps throughout the basin, but the model had lower consistency compared with ground measurement (R = 0.66) and yielded many low values. The results of this study suggested that machine learning methods had considerable potential in reconstruction of ET at regional scale.
Kinetic Study of Fig Syrup Fermentation by Genetically Modified Saccharomyces cerevisiae Yeast Sstrains. A Physicochemical Approach to the Yeast Strain Life Cycle
Authors: Kassoumi Konstantina , Sevastos Dimitrios , Koliadima Athanasia
Published: January 2024

Reversed Flow Gas Chromatography (R.F.G.C.) was employed to assess the impact of genetic modification on Saccharomyces cerevisiae yeast strains during the process of alcoholic fermentation, utilizing fig syrup. Multiple fermentations were carried out at various temperatures to evaluate the influence of genetic modifications on yeast strain efficiency. The study involved a wild-type yeast strain, W303, as a control, and two genetically modified strains, W_M4_533 and W_M4_558, sharing the same genetic background as the wild type. Notably, the genetic modifications in the Msn4p transcription factor involved the substitution of serine residues with alanine at positions 533 and 558, resulting in the development of psychrophilic or ethanol-resistant strains. Utilizing the R.F.G.C. method enabled the differentiation of the duration of alcoholic fermentation phases, providing insights correlated to the yeast cell life cycle. The values of rate constants (k) for each phase, conducted with both wild-type and genetically modified cells using RFGC, aligned with existing literature. Additionally, the calculation of activation energies for distinct phases revealed lower values for genetically modified strains compared to wild-type strains. This decrease in activation energies suggests enhanced efficiency in the alcoholic fermentation process for the genetically modified strains.
Effects of Dredging on Nitrogen and Phosphorus Storage Pat-Terns and Retention Mechanisms in Column Core Sediments in the Caohai Region of Dianchi Lake
Authors: Liu Mingyan , Yang Yan , Shao Zhi , Liu Yaping , Wang Ziqi , Chen Zhengqing , Chen Mingang , Jiao Lixin , Song Di , Li Jingyu , Wang Jing
Published: January 2024

Dredging is a common technique for managing eutrophication problems in waters, reducing the accumulation of pollutants by removing sediments from the bottom of water bodies. However, dredging can cause complex impacts on lake ecosystems, and it is crucial to understand benefits and mechanisms for environments. In this paper, the dredged and undredged areas in the Caohai portion of Dianchi Lake were studied to analyze the effects of dredging on nitrogen-phosphorus transport and conversion and changes in nitrogen-phosphorus morphology content and its mechanisms by comparing the nitrogen-phosphorus morphology content, percentage; nitro-gen-phosphorus ratio, and release contribution of the two areas. It was found that the ratio of sta-bilized nitrogen (SN) to stabilized phosphorus (SP) in the dredged area was lower than that in the non-dredged area; the BD-P and TOC contents had a large turnaround at the 16-20 cm position of the sediment in the dredged area; and the main conclusions were that the dredging would disrupt the internal equilibrium of the lake system for many years, and in particular, it would have the greatest effect on the balance of the BD-P in the phosphorus forms of the sediment, and that the column cores of the dredged area from 0 to 16 cm might be newly accumulated sediments after the dredging project. However, with time, the distribution of nitrogen and phosphorus forms in the newly accumulated sediments will gradually reach a new equilibrium. In addition, dredging will also cause significant changes in the retention efficiency of nitrogen and phosphorus in the sediment, and the stable nitrogen and phosphorus forms will be released and transformed into unstable ni-trogen and phosphorus forms.
Acyclic Diene Metathesis (ADMET) Polymerization for Synthesis of Chemically Recyclable Bio-based Aliphatic Polyesters
Authors: Nomura Kotohiro , Wang Xiuxiu
Published: January 2024

Recent development for synthesis of bio-based long chain aliphatic polyesters by acyclic diene metathesis (ADMET) polymerization of α,ω-dienes, derived from plant oils and bio-based chemicals, like bis(10-undecenoate) with isosorbide, using ruthenium-carbene catalysts have been reviewed. Development of subsequent (one-pot) tandem hydrogenation afforded saturated polyesters under mild conditions. The polymerizations under bulk (without solvent, 80-90 ºC) or in ionic liquids (50 ºC) under vacuum conditions enabled synthesis of high molar mass polymers (Mn >30,000 g/mol). The polymerization by molybdenum-alkylidene catalyst afforded the highest molecular weight polyesters (44000‒49400 g/mol, in toluene at 25 ºC) exhibiting promising tensile properties (strength and elongation at break) beyond polyethylene, polypropylene. Depolymerizations of these polyesters including closed loop chemical recycling were also demonstrated. Catalyst developments (more active, under mild conditions) play a key role for the efficient synthesis.
Safety and Immunogenicity of the Monovalent Omicron XBB.1.5-Adapted BNT162b2 COVID-19 Vaccine in Individuals ≥12 Years Old: A Phase 2/3 Trial
Authors: Gayed Juleen , Diya Oyeniyi , Lowry Francine S. , Xu Xia , Bangad Vishva , Mensa Federico , Zou Jing , Xie Xuping , Hu Yanping , Lu Claire , Cutler Mark , Belanger Todd , Cooper David , Koury Kenneth , Anderson Annaliesa S. , Türeci Özlem , Şahin Uǧur , Swanson Kena A. , Modjarrad Kayvon , Gurtman Alejandra , Kitchin Nicholas
Published: January 2024

Vaccination remains an important mitigation tool against COVID-19. We report 1-month safety and preliminary immunogenicity data from a substudy of an ongoing, open-label, phase 2/3 study of monovalent Omicron XBB.1.5-adapted BNT162b2 (single 30-μg dose). Healthy, participants ≥12 years old (N=412 [12‒17 years, N=30; 18‒55 years, N=174; >55 years, N=208]) who previously received ≥3 doses of a US-authorized mRNA vaccine, the most recent being an Omicron BA.4/BA.5-adapted bivalent vaccine ≥150 days before study vaccination, were vaccinated. Serum 50% neutralizing titers against Omicron XBB.1.5, EG.5.1, and BA.2.86 were measured 7 days and 1 month after vaccination in a subset of ≥18-year-olds (N=40) who were positive for SARS-CoV-2 at baseline. Seven-day immunogenicity was also evaluated in a matched group who received bivalent BA.4/BA.5-adapted BNT162b2 in a previous study (NCT05472038). There were no new safety signals; local reactions and systemic events were mostly mild to moderate in severity, adverse events were infrequent, and none led to study withdrawal. The XBB.1.5-adapted BNT162b2 induced numerically higher titers against Omicron XBB.1.5, EG.5.1, and BA.2.86 than BA.4/BA.5-adapted BNT162b2 at 7 days and robust neutralizing responses to all 3 sublineages at 1 month. These data support a favorable benefit-risk profile of XBB.1.5-adapted BNT162b2 30 μg. NCT05997290
Sustainable Emotional Design Based on Industry 4.0 of Industrial Nougat Packaging
Authors: Casales-Garcia Vicente , De las Heras Ana , Luque Amalia , Gonzalez-Abril Luis
Published: January 2024

Nowadays, digitalization present in all links of the product life cycle and within product design, packaging is a critical element, as it affects the customer’s purchase intention, and therefore, it is one of the most important spaces where to include techniques and methods based on Industry 4.0 that obtain results from the user and bring them closer to the process. The relationship between packaging and the expected quality and emotions of users is a topic that is addressed in the social axis of sustainability and involves an effort to strengthen the relationship with the user. This article studies the expected quality of nougat packaging in terms of shape and colour using ANOVA analysis. For this purpose, a survey was carried out among 122 participants in Spain and Mexico. The main conclusion is that a packaging with the combination of three shapes (rectangle, square and triangle) and colours (yellow, orange and red) enhances consumers’ emotions of admiration, satisfaction, pleasant surprise, attraction, fascination and joy.
Diagnostic Value of Urine Cytology in Pharmacologically Forced Diuresis for Diagnosis and Follow-Up of Upper Tract Urothelial Carcinoma
Authors: Giudici Nicola , Blarer Jennifer , Sathianathen Niranjan , Burkhard Fiona C. , Wuethrich Patrick Y. , Thalmann George N. , Seiler Roland , Furrer Marc A.
Published: January 2024

We performed urine cytology analysis of a pharmacologically induced diuresis for diagnostics of upper tract urothelial carcinoma. To evaluate the diagnostic value of cytology of pharmacologically forced diuresis, a first cohort of 77 consecutive patients with primary upper tract urothelial carcinoma treated with radical surgery was enrolled. To evaluate pharmacologically forced diuresis cytology as follow-up procedure, a second cohort of 1250 patients who underwent radical cystectomy for bladder cancer was selected. In the first cohort, sensitivity of cytology of pharmacologically forced diuresis in patients with invasive, high-grade, low-grade, and concomitant carcinoma in situ was 8%, 9%, 0% and 14%, respectively. In the second cohort, cytology of pharmacologically forced diuresis was positive in 30/689 (4.3%) of patients, in whom upper urinary tract recurrence was present in 21/30 (70%) and urethral recurrence in 8/30 (26%) of cases. As a follow-up tool, cytology of pharmacologically forced diuresis showed a sensitivity, specificity, and positive and negative predictive value of 60%, 99%, 70% and 98%, respectively.
Summarized, as diagnostic tool, sensitivity of cytology of pharmacologically forced diuresis is slightly better in patients with invasive upper tract urothelial carcinoma and concomitant carcinoma in situ. As follow-up method, positive cytology of pharmacologically forced diuresis is strongly related to cancer recurrence and can reveal urethral recurrence. cytology of pharmacologically forced diuresis might be useful in patients with contraindications for imaging or with difficult endoscopic access to the upper urinary tract.
The Influence of Concentrations of Sensitizers and Activators on Luminescence Kinetics Parameters of Upconversion Nanocomplexes NaYF4:Yb3+/Tm3+
Authors: Burikov Sergey , Filippova Ekaterina , Proydakova Vera , Kuznetsov Sergey , Voronov Valery , Tabachkova Natalia , Dolenko Tatiana
Published: January 2024

For colloids of NaYF4:Yb3+/Tm3+ nanoparticles in DMSO by the method of time-resolved lumi-nescence spectroscopy with nanosecond pulsed excitation at a wavelength of 975 nm the photo-physical processes that determine the course of kinetic curves have been revealed.
It has been found that the luminescence rise time decreases with an increase of the concentration of activators and sensitizers due to increase of the efficiency of energy transfer from sensitizers to activators. Cross-relaxation of the excited states of activators provides a decrease of the lumi-nescence decay time with an increase of the concentration of activators and a constant concentration of the sensitizer. There was no correlation between the time of luminescence decay with the change of the concentration of sensitizers and constant concentration of activators due to the competition of the processes of energy back transfer from activators to sensitizers and the "feeding" of activators by excitations coming from remote sensitizer ions.
Antibiotic Resistance in Seawater Samples From the Spanish East Coast
Authors: Dasí Diego , Camaró-Sala Maria Luisa , González Ana , García-Ferrús Miguel , Jiménez-Belenguer Ana Isabel , Castillo María Ángeles
Published: January 2024

Seawater has been proposed as a reservoir for antibiotic resistant bacteria and antibiotic resistance genes, thus representing a risk to public health. In this study, we evaluated the presence of antibiotic resistance determinants (bacteria and genes) in 77 seawater samples collected at different points along the coast of the Gulf of Valencia (Spain). Specifically, indicators of fecal contamination bacteria, Escherichia coli and Enterococcus sp. were isolated, and their antibiotic resistance profiles were analyzed by using the Sensititre® system, followed by the detection of main antibiotic resistance genes (blaTEM, qnrS, tetW, sulI, and ermB). The highest frequencies of resistance in E. coli isolates were detected against ampicillin (35.1%) and ciprofloxacin (17.5%), followed by sulfamethoxazole and trimethoprim (15.7%), while 23% of enterococci isolates showed resistance to a single antibiotic, 20% against tetracycline and 3% against daptomycin. By PCR, 93% of the E. coli strains showed the blaTEM and sulI resistance genes. Among the enterococci, the presence of the blaTEM gene was detected in 40% of the isolates, while the rest of the genes were present at very low rates. Among the water samples, 57% were positive for at least one of the tested genes, being blaTEM gene the most commonly found (47%), followed by qnrS (33%) and sulI (23%) genes. These results show that seawater, in addition to having a high rate of fecal contamination, can contribute to the spread of antibiotic resistance.
Control Device for Dual Battery Block and Fuel Cell Hybrid Power System for Electric Vehicles
Authors: Armenta-Déu Carlos
Published: January 2024

This work aims to study and analyze a hybrid power system for electric vehicles consisting of a dual low and high-rate lithium battery block and a fuel cell. In this configuration, the high-rate lithium battery powers the electric vehicle in high power demand processes like acceleration mode or on an uphill road; the low-rate battery operates at a low output power range, servicing the auxiliary systems and low power loads and the fuel cell supplies energy at intermediate power demand conditions, normal driving mode, constant velocity, or flat and downhill terrain. The dual power system improves global efficiency since every power unit operates optimally depending on driving conditions. Power sharing optimizes the lithium battery performance and fuel cell capacity, minimizing the size and weight of each energy system and enlarging the driving range. A comparative study between different lithium battery configurations and fuel cell shows an efficiency improvement of 31.4% for the hybrid dual battery block and fuel cell operating in low, high, and intermediate output power ranges, respectively. The study bases on a simulation process recreating current driving conditions for electric cars in urban, peripheral, and intercity routes. An alternative solution consisting of a hybrid system, fuel cell and a high rate lithium battery produces a 29 % power gain.
Comparison of Electromagnetic Induction and Electrical Resistivity Tomography in Assessing Soil Salinity: Insights From Four Plots With Distinct Soil Salinity Levels
Authors: Paz Maria Catarina , Castanheira Nádia Luísa , Paz Ana Marta , Gonçalves Maria Conceição , Monteiro Santos Fernando , Farzamian Mohammad
Published: January 2024

Electromagnetic induction (EMI) and electrical resistivity tomography (ERT) are geophysical techniques measuring soil electrical conductivity, providing insights into properties correlated with it, to depths of several meters. EMI measures apparent electrical conductivity (ECa, dS m−1) without physical contact, while ERT acquires apparent electrical resistivity (ERa, ohm m) using electrodes. Both involve mathematical inversion to obtain models of spatial distribution for soil electrical conductivity (σ, mS m−1) and electrical resistivity (⍴, ohm m), respectively, where ⍴ is the reciprocal of σ. Soil salinity can be assessed from σ over large areas by a calibration process consisting of a regression between σ and the electrical conductivity of the saturated soil paste extract (ECe, dS m−1), used as a proxy for soil salinity. This research aims to compare the prediction abilities of the faster EMI to the more reliable ERT for estimating σ and predicting soil salinity. The study conducted surveys and sampling at four locations with distinct salinity levels in Portugal, analysing the agreement between the techniques and obtained 2D vertical soil salinity maps. In our case study, the agreement between EMI and ERT models was fairly good in three locations, with σ varying between 50 and 500 mS m−1. However, this was not the case at location 4, where σ exceeded 1000 mS m−1 and EMI significantly underestimated σ, when compared to ERT. As for soil salinity prediction, both techniques generally provided satisfactory and comparable regional-level predictions of ECe, and the observed underestimation in EMI models did not affect significantly the overall estimation of soil salinity. Consequently, EMI demonstrated an acceptable level of accuracy in comparison to ERT in our case studies, supporting the confidence in utilizing this faster and more practical technique for measuring soil salinity over large areas.