bluuebunny/crossref_metadata_2025 huggingface dataset:
The mutational landscape of genetic cholestatic diseases in Pakistani children
Authors: Cheema Huma Arshad , Waheed Nadia , Anjum Saeed  , Anjum Muhammad Nadeem , Fayyaz Zafar , Ijaz Sadaqat
Published: July 2023

Objective: To report the mutational landscape of a clinically diagnosed cohort of paediatric patients with cholestasis liver diseases.
Method: The retrospective study was conducted at the University of Child Health Sciences, The Children Hospital, Lahore, Pakistan, from December 10, 2021, to March 31, 2022, and comprised data collected from the Paediatric Gastroenterology and Hepatology unit on demographics, clinical and laboratory findings related to children of either gender aged <12 years and diagnosed with cholestatic liver disease from July 2018 to June 2021. The diagnosis was based on clinical and biochemical findings, with no evidence of biliary atresia and metabolic liver disease. Molecular characterisation was done through whole exome sequencing.
Results: Of the 171 children evaluated, 92(53.8%) were diagnosed with genetic cholestatic disorders. There were 52(56%) boys and 41(44%) girls. The median age at presentation was 19.5 months (interquartile range: 51 months). Consanguinity was found in 82(88.1%) cases, and positive family history with one or more affected siblings was noted in 60(64.5%). Exome sequencing identified pathogenic mutations in 13 genes underlying the hereditary cholestasis; ATP8B1, ABCB11, ABCB4, TJP2, NR1H4, DCDC2, ACOX2, AKR1D1, HSD3B7, ABCC2, USP53, SLC10A1, and SLC51A. Of the 70 variants identified, 50(71.4%) were novel variants. The ABCB11-related hereditary cholestasis was the most frequent 27(29%), followed by ABCB4 (26(27.9%).  Homozygosity was frequently seen in all except 8(8.6%) children, who had compound heterozygous pathogenic variants. There was no evidence of phenotypic expression in the carrier parents despite the severe nature of the respective mutations identified in the patients.
Conclusions: Genetic heterogeneity of paediatric intrahepatic cholestasis showed recurrent and novel mutations.
Key Words: Cholestasis, Progressive familial intrahepatic cholestasis, Neonatal sclerosing cholangitis, Genetic mutation, USP53, Bile acid synthetic defects, CLD.
Nutritional risk assessment of Critically Ill patients based on NUTRIC score at Shifa International Hospital, Islamabad
Authors: Bibi Zainab , Safdar Mahpara , Khan Rezzan
Published: July 2023

Objective: To assess the nutritional risk of critically ill patients.
Method: The single-centre, prospective, observational study was conducted at the Shifa International Hospital, Islamabad, Pakistan, from November 9, 2020, to May 8, 2021, and comprised critically ill patients of either gender admitted to pulmonology, neurology, nephrology, cardiology, gastroenterology and general intensive care units. They were subjected to screening using the Nutritional Risk of Critically Ill tool, and the risk was categorised as moderate and high. Data was analysed using SPSS 23.
Results: Of the 88 patients, 58 (66%) were males. The overall mean age of the sample was 62.71±12.62 years. The nutritional risk was moderate in 39(44%) patients and high in 49(56%). The mean Acute Physiology, Age and Chronic Health Evaluation II score, Sequential Organ Failure Assessment score and Nutritional Risk of Critically Ill was 16.73±4.34, 5.91±1.92 and 5.71±1.41, respectively. There was a significant association of nutritional risk with age (p=0.04) and Sequential Organ Failure Assessment score (p<0.001). Biochemical markers were different between those with high risk and patients with moderate risk (p<0.05).
Conclusion: The overall prevalence of malnutrition in critically ill patients was high which may further affect clinical outcomes.
Key Words: Nutritional status, Malnutrition, Nutritional assessment, Risk assessment.
Case report of a rare incidentaloma of the adrenal gland—Schwannoma
Authors: Usama Muhammad Kathia  , Azfar Ali  , Ammar Tariq Alvi  , Ali Waqar Chaudhry  , Hamid Elahi  , Khizar Hayat Gondal
Published: July 2023

The Schwannoma is a benign growth of the nerve sheath cells most commonly seen in the vestibulocochlear nerve. Its prevalence in the adrenal gland is 1-3%. Here we discuss a case that presented as an incidentaloma of the right adrenal gland in a young male patient who had vague abdominal symptoms and a normal hormonal profile. He underwent an excisional biopsy of the right adrenal gland due to the large size of the lesion (more than 4cm). The histopathology report helped to establish the diagnosis of Schwannoma. Incidentaloma is defined as a lesion of the adrenal gland encountered on any radiological investigation carried out for symptoms that are not associated with adrenal pathologies. After discovering such lesions, it is imperative to perform radiological and hormonal investigations in an organised manner to plan further management of such cases.
Keywords: Schwannoma, Adrenal Incidentaloma, Adrenocortical Adenoma, Adrenocortical Carcinoma, Adrenalectomy.
Post-stroke swallowing and communication complications: prevalence and association with comorbid conditions and risk factors
Authors: Ehsaan Fazaila , Mumtaz Nazia , Saqulain Ghulam
Published: July 2023

A cross sectional study utilising convenience sampling was conducted to determine the co-morbidities and risk factors in post stroke patients with swallowing and communication complications. The study recruited 150 diagnosed cases of stroke with no gender and age limitation from Combined Military Hospital, Fatima Memorial Hospital, and Mayo Hospital, Lahore, from January to June 2015. Glasgow coma scale, Modified Massey Bedside Swallow Screener, informal clinical assessment by SLP, and medical history sheet were employed for data collection, while the data was analysed using SPSS -23. Results revealed 103 (68.7%) patients with swallowing and 99 (66%) with communication difficulties. Swallowing issues revealed significant association with age (p=.016); history of stroke (p=.017), smoking (p=.004), alcohol intake (p=.035), diabetes mellitus (p=.003), and GCS (p=.009). Communication difficulties had significant association with hypertension (p=.029), GCS (p=.000).
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Prevalence of cyberchondria among university students: an emerging challenge of the 21st century
Authors: Sabeen Sabir  , Naqvi Irum
Published: July 2023

Objectives: To investigate the prevalence of cyberchondria among university students, and to explore their self-diagnosis behaviour.
Method: The cross-sectional study was conducted in different cities of Pakistan from September 2021 to July 2022. Participants were approached through purposive sampling at different institutions of higher education and were asked about access to internet. Data was collected using a demographic proforma and through the self-reporting Cyberchondria Severity Scale-Short Version. Data was analysed using SPSS 26.
Results: Of the 500 subjects, 248(49.6%) were male and 252(50.4%) were female. The overall mean age of the sample was 24.14±3.68 years (range: 18-45 years). Of the total, 286(57.2%) subjects were diagnosed with some medical condition, 214(42.8%) self-diagnosed themselves, 302(60.4%) rated their health status as fair, 123(24.6%) rated their health status as good, and 320(64%) said they did not check the accuracy of health-related information. The prevalence of cyberchondria was moderate 252(50.4%) to high 119(23.80%) which indicates the severe severity level of cyberchondria among students. The prevalence of cyberchondria was moderate in women 151(60%) compared to men 101(40.7%). Mean scores of women on cyberchondria severity scale were higher than men (p<0.01). Cyberchondria was more prevalent among individuals with diagnosed medical condition (p<0.01) and those who self-diagnose their symptoms via the internet (p<0.001).
Conclusions: Cyberchondria must be seen as a serious public health concern in Pakistan. Since it is associated with distress and worry, measures need to be adopted to evaluate, prevent, and treat it at the population level.
Key Words: Cyberchondria, Health anxiety, Online health information searches, Self-diagnosis, Diagnosed medical condition.
Prevalence of robotic surgery in Pakistan
Authors: Naveed Hufsa , Tooba Naveed  , Areeba Farooqui
Published: July 2023

Dear Editor,
Robot-assisted surgery is a medical procedure that utilizes specific innovation that improves the abilities of one’s surgical skills. It enables surgeons to perform complicated surgeries in difficult-to-reach areas via small incisions. The innovation comprises of 1-Surgical arms with tiny instruments with wrists at the tip, 2-Special camera that gives improved, amplified 3D perspectives on the region 3-Surgical Control Centre where the surgeon controls the instrument and the camera. (1) Experts who utilize robotic surgery find that it develops exactness, versatility, and control during the movement and permits them to see complex areas that are not visible through other techniques. Utilizing robotic surgery procedures, experts can do delicate and complex medical procedures that may be inconvenient with traditional procedures (2)
Often, robotic surgery procedures make beyond belief prominent clinical therapies possible. The benefits of fewer obtrusive medical procedures include fewer bothers, less blood loss; speedier recovery; and fewer unmistakable scars. (2) Automated robotic surgery is now practice in Pakistan by the Sindh Institute of Urology and Transplantation. Around the globe, robotic surgery has caught the attention of many physicians and is also used for other organ surgeryDespite mainstream thinking, it doesn't imply that robots are doing your medical procedure. All things being equal, a specialist controls robotic arms with outrageous accuracy. During robotic surgery, a specialist utilizes a PC to control the robotic arms that go through the method. Robotic surgery gives her unparalleled adaptability and accuracy during medical procedures. (3)
In conclusion, Pakistan needs to care for an enormous pool of patients connected with the prostate, kidney, gall bladder, different tissues and organs. The current ratio of 0.473 physicians per 1,000 population in Pakistan is inadequate to maintain the nation's health. (4) Healthcare system frameworks all over the world have been changed over the most recent couple of years, bringing about a more prominent need and interest for surgical schooling outside operation theatres Lastly, the general well-being area of Pakistan ought to likewise make plans to import equipment,/ machines from organizations with the goal that it is made accessible in hospital across the country. Subsequently, this will help our careful division in its progression from a medical procedure to robotic assisted priesion medical procedure.
Devastating floods and period poverty: Leaving women exposed to severe health outcomes
Authors: Hina Aslam  , Syeda Aiman Rizvi
Published: July 2023

Period poverty is the lack of access to menstrual supplies, hygiene education, and waste management which can lead to severe health outcomes. In developing countries like Pakistan, menstruation and menstrual practices still face many social, cultural, and religious restrictions, which form a barrier to menstrual hygiene management and creating awareness, especially in less privileged areas of the country. However, in the present condition of catastrophic floods in Pakistan that has affected 33 million people leaving 1 million homeless 1 has exposed women to more vulnerable sexual reproductive and health items.
A survey which was held to check the resources used by women during current conditions of flood showed that women are using leaves, torn pieces of cloth, dirty rugs, and even cans instead of sanitary pads to manage their bleeding 2Moreover, food and water is given more priority over basic needs of women like sanitary pads, which are considered luxurious items.
By reviewing the literature, we found that lack of menstrual hygiene is one of the main causes of lower reproductive tract infections that can lead to morbidity and severe health conditions.3 Another cross-sectional study also shows same results that the more women use these unhygienic methods to manage their bleeding the more they are exposed to the risk of lower reproductive tract infections4
In 2017, a similar UNICEF supported study conducted in Pakistan t showed that 49%of women in rural areas had no menstrual knowledge prior to their menarche and 44% didn’t have access to basic menstrual hygiene needs5 All the aforementioned studies raise the question: Is sanitary pads a luxury or a necessity?
The circumstances caused by flood can be taken as an opportunity by the government to bring long-term changes by suggesting certain plans by to eradicate period poverty permanently from society. Lack of access to period products can occur mainly due to financial and physical barriers. The government should start an awareness program, and make the basic resources accessible at cheaper costs especially in less privileged and rural areas of the country that can also help to break the social taboo of not considering period products as important as food and water.
Association of Pre-Infection Vitamin D status with COVID-19 severity
Authors: Ifra Eeman Ahmed  , Azhar Ali  , Abdullah Humayun
Published: July 2023

Madam,
Vitamin D is a fat-soluble vitamin, well known for regulating serum calcium and phosphate levels by stimulating intestinal absorption, renal reabsorption of calcium in the distal convoluted tubule and bone calcium mobilization. As an important modulator of innate immunity, reduced vitamin D levels have been linked to the development of different autoimmune disorders and increased susceptibility to infectious diseases(1). Vitamin D pivotal role in inhibiting cytokine storm and inflammation reactions(1). It is reported that the active form of vitamin D enhances the antimicrobial effect of macrophages and monocytes(1). It is also involved in the stimulation and production of lymphocyte function and it also supports the differentiation and function of natural killer cells (1).
Since December 2019, COVID-19 caused by SARS-CoV-2 has spread all over the globe causing unparalleled health, social and economic crises. Initially, an association of vitamin D status with SARS-CoV-2 infection was observed which has sparked debate over the advantages of vitamin D in preventing and treating this disease. A greater risk of COVID-19 was substantially related with low serum 25-(OH) Vitamin D levels. It also suggests that the patients with Vitamin D deficiency had poorer outcomes leading to comparatively longer stays in the Intensive Care Unit (ICU), and had a higher fatality rate. (2).
There is much debate about whether infections caused the low D3 levels or whether a deficiency adversely affects the immune system. Recently, Amiel et al. discussed that among hospitalized COVID-19 patients, pre-infection vitamin D insufficiency was linked to increased disease severity and mortality in hospitalized COVID-19 patients.(3). This study presents convincing evidence that low D3 levels are a predictor rather than a side effect of infection (3). The study by Lorenz et. al. suggested that 50ng/mL of 25-(OH)D3 might potentially result in a mortality rate close to zero(4).
According to a systematic review and meta-analysis of the incidence of vitamin D deficiency among South Asian adults, about seven out of ten individuals in this region are vitamin D deficient.(5). Owing to the study Amiel et al. we suggest it would be reasonable to encourage daily sun exposure and fortification of food items with vitamin D.
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A novel experience of ultrasound-guided erector spinae plane block with sedation in breast cancer surgery: a case report
Authors: Alam Tanveer , Qureshi Rabeea Sajid , Mehdi Syed Raza
Published: July 2023

We are reporting the anesthetic management of a breast cancer patient with a high risk to undergo general anesthesia using a single shot ultrasound guided Erector Spinae Plane Block (ESPB) with monitored sedation. Targeted at T4, 20 mL of 0.375% Bupivacaine provided complete surgical anesthesia in 15 minutes. Concurrent sedation was administered with Target Controlled Infusion of Propofol with Entropy monitoring throughout the procedure. The surgery lasted 90 minutes and the patient remained pain free and hemodynamically stable throughout. At the end of the surgery, the patient received 1g Paracetamol intravenously, and did not require any further analgesics other than routinely administered Paracetamol until her discharge from the hospital. On top of the successful execution of our plan, this case was especially interesting as her postoperative analgesia remained completely opioid free.
Keywords: Ultrasound, breast cancer, esp block, erector spinae plane block, fascial plane block, pain, analgesia, regional anesthesia.
Learning Innovations in Training Activities: A Systematic Literature Review
Authors: Waritsman Arsyil , Djanapa Bulow Irma
Published: July 2023

This study aims to describe the innovations that have been applied in learning in training activities and describe the impact of the application of learning innovations on training activities. The method used in this study is a Systematic Literature Review. Data collection is carried out by documenting and reviewing articles either in national journals or proceedings of national seminars related to learning innovations applied to training and articles related to the impact of learning innovations in the period 2012 to 2021. The data were analyzed using a qualitative descriptive approach by going through four stages, namely data collection, data reduction, data presentation, and conclusion drawing. The findings show that the learning innovations applied to training are in the form of the application of e-learning, open design training models, interactive training methods, the use of learning media with the help of canva, the creation of video-based learning media, innovations in the training curriculum, and the implementation of blended learning in training activities by utilizing the use of the application and web-based information technology such as zoom, moodle-based learning management system (LMS) and google meetings. Then, information was also obtained that the impact of the application of learning innovations included the improvement of human resource professionals, increasing the performance of human resources, and the formation of active and creative human resources at work.
Development of BAPAU (Manual Book of Long-Distance Training for BDK Ambon Employees)
Authors: Amahoroe Riana Antika
Published: July 2023

Distance Training (PJJ) has become one of the training trends after the Covid-19 pandemic hit Indonesia. PJJ utilizes the Learning Management System (LMS) as a learning medium. Therefore, the researcher developed a BAPAU (Distance Training Handbook) for Ambon BDK Employees which explains in detail how to use the LMS, the functions of the features in the LMS and how to use them. The research used the Research and Development (R&D) method with the ADDIE model. 5 stages in the ADDIE model, namely the stages of Analysis (Analyze), Design (Design), Development (Development), Implementation (Implement), and the last stage, namely Evaluation (Evaluation). Based on the results of the development research that has been carried out, it can be concluded that the BAPAU for Ambon BDK Employees is very appropriate to use as a guide for PJJ.
Graha Block, Inovasi Block Rumah Adat Berbasis Permainan Interaktif Untuk Melestarikan Kebudayaan Tradisional Indonesia
Authors: Agustiyar Fandika , Rizqiyana Dewi , Riyanto Aldi , Hidayah Nur , Alam Sabda , Pudyastowo Rema Bagos , Suherman Suherman
Published: July 2023

Arsitektur rumah tradisional Indonesia merupakan warisan budaya yang sangat penting yang dimiliki bangsa ini. Rumah tradisional tidak hanya berfungsi sebagai tempat tinggal, namun juga representasi dari nilai budaya yang menggambarkan perilaku masyarakat. Akan tetapi, kini arsitektur rumah tradisional mulai terpinggirkan oleh banyaknya desain atau konsep rumah modern sehingga dibutuhkan usaha kreatif untuk mempopulerkan kembali arsitektur rumah tradisional Indonesia. Grha Block merupakan mainan berbasis block yang dibuat berbentuk arsitektur rumah tradisional Indonesia dengan tujuan untuk mempopulerkan bentuk rumah adat Indonesia. Langkah-langkah yang dilakukan untuk menjalankan usaha, yaitu: perencanaan usaha, produksi, pemasaran dan pengembangan usaha. Grha Block mengusung tiga jenis arsitektur yaitu Rumah Gadang (Sumatra Barat), Rumah Joglo (Jawa Tengah) dan Rumah Tongkonan (Sulawesi Selatan) serta dilengkapi informasi seputar budaya dan rumah adat yang bersangkutan yang dapat diakses melalui barcode pada kemasan produk. Grha Block telah terjual 9 unit dalam 21 hari dengan omzet Rp3.148.000,00 sedangkan titik impas adalah 17 unit dalam 81 hari dengan omzet Rp6.770.000,00. Grha Block dapat menjadi sarana edukasi budaya bagi masyarakat melalui bentuknya yang unik dan menarik serta bernilai bisnis dan layak untuk dikembangkan.
Pengaruh Kompetensi Guru terhadap Pengetahuan Siswa dan Minat Menabung Siswa di Bank Mini Sekolah
Authors: Akmal Akmal , Juliana Novela
Published: July 2023

Rendahnya minat menabung siswa di SMK Muhammadiyah 2 Pekanbaru pada Bank Mini Sekolah memunculkan beberapa hipotesis mengenai pengetahuan tentang literasi keuangan, minat menabung dan pengaruh kompetensi guru. Tujuan dari penelitian ini adalah bertujuan untuk mengetahui Pengaruh kompetensi guru dalam meningkatkan pengetahuan literasi keuangan siswa di SMK Muhammadiyah 2 Pekanbaru. Serta adanya pengaruh tidak langsung kompetensi guru terhadap minat menabung melalui pengetahuan literasi keuangan siswa di Bank Mini Sekolah SMK Muhammadiyah 2 Pekanbaru. Metode dalam penelitian ini adalah menggunakan pendekatan deskriftif kuantitatif. Hasil penelitian ini adalah ada pengaruh signifikan kompetensi guru terhadap pengetahuan literasi keuangan siswa di SMK Muhammadiyah 2 Pekanbaru SMK Muhammadiyah 2 Pekanbaru, ada pengaruh tidak langsung kompetensi guru terhadap minat menabung melalui pengetahuan literasi keuangan siswa di SMK Muhammadiyah 2 Pekanbaru. Simpulan dari penelitian ini bahwa hipotesis pada penelitian ini diterima.
Pengaruh Tingkat Pendidikan dan Pendapatan terhadap Minat Menabung
Authors: Apriani Dian , Faozan Akhmad
Published: July 2023

Menabung memiliki peran yang sangat penting bagi masa depan karena menabung merupakan salah satu cara untuk mengelola keuangan. Menabung berarti menyisihkan uang yang kita miliki untuk disimpan. Menabung juga merupakan bagian dari perencanaan keuangan untuk menghadapi kebutuhan yang akan mendatang. Penelitian ini bertujuan untuk mengukur pengaruh tingkat pendidikan dan pendapatan terhadap minat menabung pada masyarakat Dusun Pondoknangka Barat, Desa Beluk, Kecamatan Belik, Kabupaten Pemalang. Pengambilan sampel menggunakan accidental sampling dengan jumlah responden sebanyak 100 responden. Data yang diperoleh kemudian diolah menggunakan program SPSS menggunakan teknik analisis regresi linier berganda. Hasil penelitian menunjukkan adanya pengaruh signifikan antara tingkat pendidikan dan pendapatan secara simultan terhadap minat menabung.
Strategic Leadership Analysis of School Principal to Improve Learning Quality
Authors: Safrida Safrida , Tannady Hendy , Solissa Everhard Markiano , Sapulete Heppy , Haddar Gamar Al
Published: July 2023

To create a good quality of generation, education must be carried out from an early age, in this case through Early Childhood Education (PAUD), namely education aimed at children from birth to the age of six. Quality education is not only seen from the quality of its graduates, but also includes how schools are able to meet customer needs in accordance with applicable quality standards. Principals are required to have the right leadership and strategy to increase the professionalism of teaching staff in their schools, so they are able to create a conducive school climate, provide advice to school members, provide encouragement to all teaching staff and implement an interesting learning model. In addition to carrying out its functions, the principal has the task of developing a strategy and mission so that he knows which way to go and knows how to get there in order to achieve the operational goals of an educational institution. In improving the quality of education the principal must improve the quality of a teacher in order to achieve a better quality of education. Make a program in one academic year, in the form of an annual program and a semester program. Adding infrastructure so that the teaching and learning process can run well.
Role of Work Experience, Work Motivation and Educational Background on Teacher Performance at Vocational School
Authors: Nugroho Budi Sulistiyo , Tannady Hendy , Fuadi Tuti Marjan , Aina Mia , Anggreni Made Ayu
Published: July 2023

Teacher performance is very necessary for the progress of the nation and this of course relies on the teacher. This of course requires special assessment and attention. This researcher aims to determine the effect of education, work experience and motivation on teacher performance at one of vocational school. The research method used quantitative methods. The variables used in this study were education, work experience and motivation as independent variables and teacher performance as the dependent variable. In the data collection process, it was carried out using a questionnaire which was distributed to 37 respondents, namely all vocational school teachers. The data obtained was then processed using the multiple linear regression analysis method with IBM SPSS Statistics 26 software. The results showed that education had a significant effect on teacher performance, work experience and motivation had a positive and significant effect on teacher performance.
Pengembangan Instrumen Penilaian Pemahaman Konsep Business Model Canvas pada Mata Kuliah Kewirausahaan
Authors: Machsunah Yayuk Chayatun , Nurdiana Ratna , Sutarum Sutarum
Published: July 2023

Business Model Canvas (BMC) adalah business model yang harus dikuasai mahasiswa dalam mata kuliah kewirausahaan sebagai bekal awal terjun dalam dunia wirausaha. Penelitian ini akan menghasilkan instrumen penilaian guna mengukur pemahaman konseptual mahasiswa dalam materi BMC yang terdiri dari 9 aspek penilaian yaitu Customers Segment, Value proposition, Customer Relationship, Channel, Revenue Stream, Key Resource, Key aktivities, Key Partnership, dan Cost Structure. Instrumen penilaian dikembangkan menggunakan model ADDIE (Analysis, Design, Development,  Implementation and Evaluations). Validitas konten dilakukan oleh validator ahli dan diperoleh nilai sebesar 93,75% yang artinya sangat valid. Sedangkan hasil analisis statistik diperoleh nilai korelasi lebih dari 0,30. Ini berarti seluruh aspek penilaian tersebut dinyatakan valid. Nilai reliabilitas Cronbach’s Alpha diperoleh sebesar 0,886  artinya  instrument memiliki kemampuan sangat kuat dalam alat ukur penelitian, sehingga dapat disimpulkan bahwa instrumen penilaian pemahaman konseptual BMC valid dan layak untuk digunakan pada materi business model mata kuliah kewirausahaan
Analisis Pengaruh Model Pembelajaran Student Center Learning terhadap Hasil Belajar: Studi Literatur Review
Authors: Sarnoto Ahmad Zain , Rahmawati Sri Tuti , Ulimaz Almira , Mahendika Devin , Prastawa Singgih
Published: July 2023

Penelitian ini bertujuan untuk menganalisis pengaruh model pembelajaran Student Center Learning terhadap hasil belajar peserta didik. Metode studi literatur digunakan untuk mengumpulkan data dari artikel-artikel terkait pembelajaran Student Center Learning dan hasil belajar peserta didik. Data kemudian dianalisis dengan menggunakan teknik meta-analisis untuk mengetahui secara kuantitatif pengaruh model pembelajaran Student Center Learning terhadap hasil belajar peserta didik. Hasil analisis menunjukkan bahwa penggunaan model pembelajaran Student Center Learning memberikan pengaruh positif yang signifikan terhadap hasil belajar peserta didik. Implikasi dari penelitian ini adalah pentingnya penggunaan model pembelajaran yang dapat meningkatkan hasil belajar peserta didik dan dapat menjadi acuan bagi institusi pendidikan dalam pengembangan kurikulum dan metode pembelajaran yang lebih efektif.
Innovative Potential of the Oil and Gas Industry of Kazakhstan
Authors: Maldynova Aizhana , Bodaukhan Gulbagda , Aitkhojaeva Gulraykhan , Ilyas Assel , Murzabekova Baglan
Published: July 2023

The article is devoted to analysing the innovative potential of enterprises in Kazakhstan's oil and gas sector and developing ways for its effective implementation. In the current economic conditions, the issue of increasing efficiency, modernization, innovative activity and strategic partnership in the oil and gas sector is becoming especially relevant. This is since the raw material orientation of the industry poses a threat to the economic security of the country, which means that increasing the innovative potential of such an important sector for the country's GDP is an urgent problem. The authors of the article analyzed the relationship between the innovative potential of the oil and gas sector and the internal costs of innovation, and the volume of innovative products. An analysis was carried out on benchmark indicators of the country's global competitiveness index, as well as an analysis of measures to introduce innovation in Kazakhstan's oil and gas industry. The most significant technological innovations in the main segments of the oil and gas complex are given. On the basis of the research, proposals were made to increase the innovative potential of the enterprises of the oil and gas industry in Kazakhstan. The most critical strategic prospects for developing Kazakhstan's oil and gas sector are substantiated based on two directions: an increase in internal costs for innovation and an increase in the volume of innovative products.
Formation of Industrial and Logistics Hub in the Border Areas of Kazakhstan and Uzbekistan
Authors: Bodaubayeva Gulmira , Turkeeva Kulyash
Published: July 2023

Central Asia is a strategic region of the China-Europe continental bridge. The conflict between Russia and Ukraine has seriously affected international supply chains, which has led to the intensification of the development of alternative corridors and the construction of new regional logistics hubs along them. The purpose of the research is to determine, on the basis of these sources, the factors of the formation of industrial and logistics hubs, as well as the directions of their development on the example of the border regions of Kazakhstan and Uzbekistan. In preparing this article, a mixed research strategy was used, which implies quantitative and qualitative methods. It consists not only of the systematic study of the literature on the research topic and statistical information but also involves the implementation of theoretical studies, comparison, generalization and analysis of the results, argumentation and formulation of conclusions. The study identified the main constraining factors for the development of such centres delays in customs inspection, inconsistency in the legal framework of the transportation process, underdevelopment of infrastructure, low level of digitalization and the use of information systems, the use of non-tariff barriers, low level of digitalization and the use of information systems. The creation and development of integrated transport services based on a digital platform will speed up this process. In addition, taking into account these factors, the components of an industrial and logistics hub are proposed: an industrial zone, a logistics zone, a trading zone, a certification zone with appropriate services, as well as a digital platform as a link between all components.
The Study of Higher Education in the Regions of Kazakhstan: Analysis of Tools and Indicators
Authors: Nurgaliyeva Kuralay , Nygymbetov Galym
Published: July 2023

This study aimed to analyse the state of higher education in the regions of Kazakhstan based on an integrated approach according to use of statistical methods and aggregation of empirical data. In this study, the focus is on assessing the level of development of higher education institutions in Kazakhstan based on the selected three groups of variables: enrollment in higher education institutions; subjects and objects of higher professional education (number of teaching staff, number of students, number of universities); provision of services (budget, population, enterprises). The research design was divided into three stages: data collection, analysis and recommendations.  The data sample from 2010 to 2021 was taken from the annual statistical yearbooks of the Republic of Kazakhstan. In this study based on a comprehensive review of the above variables, it is proposed to conduct an analysis at the following three stages: data collection, definitions of the initial data and evaluation of the time period; sampling of initial data, analysis of collected data and interpretation; description of the results obtained; conclusions and recommendations. The practical results of the study and conclusions can be used by government agencies in the analysis and forecasting of the development of the education system in the region. The data obtained showed that there are differences in the availability of higher education in different regions of Kazakhstan. High rates in the cities of Astana and Almaty may be associated with their status as the capital and the largest city, respectively.
Geopolital and Geo-Economic Importance of the Middle Corridor: A Chompreshive Overview
Authors: Vasa Laszlo , Barkanyi Peter
Published: July 2023

The aim of the paper is to investigate the changing importance of the Middle Corridor in geopolitical and geo-economic contexts using analytical and case study methodology. The conflict in Ukraine has disrupted the traditional trade route between Asia and Europe via Russia, leading to the emergence of alternative transport options such as the Trans-Caspian International Transport Route (TITR), also known as the Middle Corridor (MC). This study examines the evolving importance of the Middle Corridor in the geopolitical and geo-economic context and highlights its potential as an alternative trade route for China-Europe trade. However, the corridor currently operates at only 10% of the capacity of the Northern Corridor, and significant efforts are needed to increase its capacity and ensure its efficient use. Successful corridor initiatives depend on effective management, trade facilitation and cross-border cooperation to overcome geographical disparities. As a result, the Trans-Caspian International Transport Route (TITR), also known as the Middle Corridor (MC), is emerging as a promising alternative for the foreseeable future. Overall, the growing importance of the Middle Corridor and other Asian economic corridors is changing regional trade and transport dynamics, requiring comprehensive management, trade facilitation and infrastructure development.
Infrastructure Design on Road Safety Along Outering Roads in Nairobi City County, Kenya
Authors: Kipchirchir Kwambai Kennedy , Moi Dr. Edna
Published: July 2023

Urban road accidents have been on the increase across the globe, including in Kenya, with far-reaching social and economic impacts. Various factors contribute to road accidents and the associated effects in the literature. The factors contributing to and influencing road accidents vary from location to location, as informed by the research studies undertaken. Consequently, the current research evaluated road infrastructure design’s effects on road safety in Nairobi City County and identify the possible solution to the causes. The research adopted an exploratory research design to answer the research questions. The study’s target population are the road users of Outering road in Nairobi’s Embakasi region, including drivers, conductors, and passengers, boda-boda operators and pedestrians. The research adopted a stratified and systematic sampling method to identify the sample population, with the sample size being 404 participants. The sample population included 308 passengers and pedestrians, 45 drivers (including boda-boda drivers), 45 conductors, four police officers, 1 KURA official and 1 NTSA official. The specific target group were drivers and conductors of Embassava and the passengers that are transported by the vehicles of the Sacco using the Outering road, as well as boda-boda operators. Semi-structured questionnaires were the primary tool for soliciting data from respondents from the target respondents. Data was analysed through descriptive analysis, correlation analysis, and regression. The study showed that road signage significantly affected road safety, while road drainage and lighting had no significant effect. The predictors accounted for 26.7% of the variance in road safety. The study is particularly relevant to policymakers and practitioners in the transport sector. The findings highlight the need for investments in infrastructure improvements that enhance road safety in Nairobi County and the importance of involving road users in designing and implementing road infrastructure projects.
Rulings on an Intended Abortion in accordance with Islamic law
Authors: Abed Abdulhanan , Osuly Abdulqudos , Yousufi Abaidulrahman , Anwari Gulaqa
Published: July 2023

Following a discussion of the various reasons why a fetus may be intentionally aborted, this article seeks to address the following question: What are the Sunni jurists' views on the legality of an intentional abortion of a fetus when the mother's life or health is in danger? The response to the question should be given by dividing the fetus' life span into two phases before and after the soul is breathed in, as well as by dividing Sunni jurists into past and present jurists, as well as according to the four well-known Sunni jurisprudence schools. The fundamental standards on which Sunni jurists have founded their opinions must be met in each of the aforementioned areas. Since determining the standards and foundation of their viewpoint can, at least in part, clarify the outcome of other factors that serve as justification for the purposeful abortion of the unborn. Although they have not said what punishment they want. It appears that all of the jurists of the past agreed that it is unlawful to willfully abort once its soul has been breathed, even if doing so would save the mother's life. The decision to purposefully terminate a baby before the soul is inhaled has been discussed from numerous angles by the four illustrious jurisprudential schools, including the majority of modern Sunni jurists, given that a fetus is a respected object at this stage. As a result, when the life of a being with a soul (such as a mother) and a being without a decent soul are in conflict, the life of the being with a soul is given priority. Because for now, saving the mother's life is the least harm that human civilization endures following the principle (of tolerating the least two harms). Some modern jurists think that it is illegal to have an abortion without a good reason if the fetus is intentionally aborted after the soul has been blown. And other people believe it is acceptable to purposefully abort the fetus without having a valid reason. However, all sides agree that if the mother's life is in danger due to the pregnancy, a purposeful abortion of the unborn will not only be acceptable but also required because this is the most obvious instance of a justifiable rationale.
A ENTREGA VOLUNTÁRIA DE CRIANÇAS RECÉM-NASCIDAS PARA ADOÇÃO: ANÁLISE BIBLIOGRÁFICA SOBRE O ACOMPANHAMENTO REALIZADO ATÉ O PARTO
Authors: Trindade Mendonça Iara
Published: July 2023

Podemos dizer que não são raras as vezes em que nos deparamos com notícias na mídia sobre mães que abandonam seus filhos pós-parto em locais como: lotes, lixões, terrenos baldios, esgoto, entre outras situações deploráveis. Diante dessa problemática, surge todo um estudo e questão de saúde pública, tornando o processo de entrega voluntária menos doloroso e mais humano, dando amparo e suporte para as mães e pais que, apesar do não interesse em permanecer com seus filhos, desejam lhes dar uma vida mais digna por meio da entrega voluntária para a adoção, garantindo aos genitores a possibilidade de manter suas identidades resguardadas sem nenhum tipo de responsabilização civil ou criminal. Objetivo: Descrever como o processo de entrega voluntária é segura e acolhedora. Métodos:  O presente artigo tem sua metodologia pautada em pesquisas bibliográficas, análise da legislação relativa ao tema, além de pesquisas de artigos da área jurisdição e projetos de lei referentes ao tema. Resultados: Os artigos inicialmente encontrados nas bases de dados, após a inserção das palavras-chave, totalizaram 100, restando 5 artigos científicos originais que cumpriram as exigências e normas da revisão interativa e que possuíam relação direta com a temática abordada. Considerações finais: A legislação brasileira mudou bastante ao que se refere à adoção, nos últimos tempos foram criados inúmeros mecanismos que possibilitam a garantia dos direitos fundamentais de crianças e adolescentes em situação de abandono familiar.
United Arab Emirates (UAE): A scientometric assessment of Covid-19 publications
Authors: Gupta B. M. , Dhawan S.M. , Kappi Mallikarjun
Published: July 2023

Objective. The United Arab Emirates continues to undertake and sustain its research pursuits in Covid-19 as a matter of strategy, considering that the country is facing unique challenges in this area of research. The paper seeks to analyze UAE publications on Covid-19 research and describe its research trends.

Methodology. A literature search on UAE publications on Covid-19 was conducted using the Scopus database, limiting the search period for the study to December 1, 2019 - April 7, 2023. Data were retrieved and downloaded for analysis using Microsoft Excel and Scopus Citation Overview tools. VOSviewer software was used to provide creative visualization of the relationships across researchers, institutions, and journals that reported UAE publications.

Results: 48,1461 publications were published on Covid-19 from December 2019 till April 7, 2023. Of these, the UAE contributed 3402 publications, constituting 0.71% share of global output and registered 14.63 average citations per article (CPP). The 732 (21.52%) UAE papers had received external funding support, and another 2493 (73.28%) papers appeared through international collaboration with countries such as the U.K (n=556), USA (n=553), India (n=448), and Saudi Arabia (n=399). The leading UAE participating organizations in Covid-19 research include the University of Sharjah (n=619), United Arab Emirates University (n=520), and Zayed University (n=239). The organizations which made the most citation impact in terms of CPP and RCI include American University in the Emirates (40.54 and 3.34), Mohammed Bin Rashid University of Medical & Health Sciences (34.4 and 2.83), and Al Jalila Children’s Specialty Hospital (31.88 and 2.62). The leading UAE participating authors in Covid-19 research include R. Halwani (n=83), Z. Umar (n=38), and Q. Hamid (n=37). The authors who made the most citation impact in terms of CPP and RCI include R. Halwani (52.61 and 4.33), H.Q. Al Shamsi (30.24 and 2.49) and A.S. Al Dhaheri (28.81 and 2.37). The most utilized channels of research communication in Covid-19 research include PLOS One (n=73), International Journal of Environmental Research & Public Health (n=46), and Scientific Reports (n=36). The journals which received the most citations for UAE papers on Covid-19 research include the International Journal of Infectious Diseases (30.56 CPP), IEEE Access (20.49 CPP), and Frontiers in Psychiatry (17.40 CPP).

Conclusion: The study presents the current status of research and the publication trends in Covid-19 in the UAE, particularly its most used sources for research publication, most productive and most cited organizations and authors, and its most sought-after topics in Covid-19 research. Strengthening research collaboration between UAE and the Middle East countries and with the developed world countries will further help UAE improve the quality and quantity of its research on Covid-19 and help implement its Covid-19 policies in the region.
Effects of non-pharmaceutical interventions for COVID-19 on influenza incidence: A systematic review
Authors: Safdar Shaheer , Read Jonathan , Safdar Samreen
Published: July 2023

Introduction Since the outbreak of coronavirus disease 2019 (COVID-19), non-pharmaceutical interventions (NPIs) have been the primary preventative measure to mitigate the COVID-19 burden. However, these NPIs have also altered the pattern and incidence of other respiratory pathogens. This review aims to explore the effects of NPIs used against COVID-19, on influenza incidence.Methods A systematic literature search was conducted in selected databases (PubMed, Medline, Embase). Documents that highlighted a change in influenza epidemiology during the COVID-19 pandemic and were linked to NPIs were included. The search covered articles from 1 January 2020 to 7 December 2022.Results This review included 13 studies reporting data from three different continents. A 14-100% decrease of influenza activity was observed since the enforcement of NPIs in early 2020.Conclusion This study suggests that the NPIs implemented during the COVID-19 pandemic have also significantly reduced influenza incidence. This is most likely because both coronavirus and influenza are transmitted through a similar route and the NPIs prevent this. The use of NPIs is suggested to overcome some burden of future influenza epidemics.
Abrogation of Article 370: The Symbol of National Integrity
Authors: Ahmad Irshad , Parihar Dr. Seema
Published: July 2023

A few specific privileges provided to citizens of the Indian state  of Jammu and Kashmir were recently abolished by the Indian  government. Under Articles 370 and 35A of the Constitution, these  rights were provisionally conferred. The Indian government placed  some limitations on travel and communication in the Kashmir valley  because it anticipates that this step may spark violent protests in the  state. Pakistan has spearheaded a defamation campaign against India  even though these prohibitions have increasingly been loosened. Over  this action, it has even threatened a nuclear exchange. The prime  minister of India Mr Narendra Modi said that more than 70,000 lives  have been lost over the past thirty years as a result of the particular  privileges that the people of Jammu and Kashmir have, which has  led to a sense of difference that has been exploited by forces opposed  to India’s unity. The neighbourhood was not getting any closer to  peace by maintaining the current quo. Hopefully, the elimination of  these articles will result in a stronger sense of national integration.  Therefore in view of the above statements this dissertation paper is  being prepared to study and spread the truth to the all citizens of India  that abrogation of article has ended all kinds of privileges and special  treatments and has paved the way to the national integration of India
Challenges and Prospects for Organic Farming: A Case Study from India
Authors: Kaur Harmandeep
Published: July 2023

Several past studies have considered organic farming as it serves as a  responsive sustainable approach to the rural development. This study  emphasises and focuses on the opportunities and constraints in organic  farming in context of India. There are several cost and marketing related  problems specific to organic food. This study identify the following areas  to addresss these problems in the country: develop a regional programme  to address specific regional problems, take into account the unique  conditions prevailing in the region; provide financial assistance for the  effective implementation of organic projects and programmes, access to  advanced technology, effective information sharing platforms. The organic  movement’s capacity for adaptation and learning from past experiences  will determine if organic farming is able to fully realise its capacity for  fostering resilience( Milestad and Darnhofer, 2003).