bluuebunny/crossref_metadata_2025 huggingface dataset:
Determinant factors of narcotics, psychotropic, and addictive substances abuse relapse in a drug rehabilitation centre in Indonesia
Authors: Raharni Raharni , Isfandari Siti , Purnamasari Telly , Susianti Andi Leny , Mujiati Mujiati
Published: March 2022

Background: Drug abuse (narcotics, psychotropics, and addictive substances) causes very broad and complex problems, including relapse. Relapse is a process that occurs due to several triggering factors where a person has been declared abstinence (recovered) returning to use drugs.       Objective: To identify the determining factors related to the recurrence of drug abuse in a drug rehabilitation center.       Methods: A cross-sectional research design, involving searching literature to find results from journals and research papers that relate to a relapse of drug use and returning to rehabilitation centers.    Results: Internal factors in the family such as ineffective functions and roles of the family, family imbalances and economic status also played a role. In addition to, communication within the family and, external factors, such as environmental and peer group variables as well as the use of free time. The influence of friends was a very dominant factor in causing relapse. Social and environmental pressures were the external factors more likely to cause relapse. The types of drugs used also affected the likelihood of relapse. Social support has an important role in the healing process of drug addiction. The drug often misused was shabu-shabu (methamphetamine), because of its affordability. Shabu-shabu is also associated with drug violence in the middle levels.      Conclusion: Factors determining the relapse of narcotics, psychotropic, and addictive substances (drugs) in drug rehabilitation centers consisted of internal factors such as gender, age, knowledge and association with old friends as well as external social and environmental pressures.
The potential of citronella grass to inhibit growth of Escherichia coli and Staphylococcus aureus bacteria
Authors: Sagala Reynelda Juliani , Kambira Pretty Falena Atmanda , Gunawan Untung , Pollin Grafty
Published: March 2022

Background: Citronella grass (Cymbopogon nardus (L.) Rendle) has a distinctive aroma that comes from its essential oils. Essential oil components, especially citronella and geraniol compounds, are known to have antifungal and antibacterial activities. Therefore, citronella grass extract can be used as an active ingredient for antiseptic hand gel products. However, it is necessary to optimise the gelling agent to get the optimal formulation.

Aim: This study aimed to determine the concentration mixture from three gelling agents that were optimal, stable, and able to inhibit bacterial growth: Sodium carboxymethyl cellulose (CMC-Na), gum arabic, and gelatin.

Method: Citronella grass was macerated using 70% ethanol. Gelling agents’ variation were evaluated based on the viscosity, spreadability, and adhesion. The most optional variation was obtained using analysis with the Simplex Lattice Design method. The antimicrobial activity of the extracts and the gel were tested using the disc diffusion method against Escherichia coli and Staphylococcus aureus.

Result: The results showed that the optimal gelling agents for the specified parameters was a mixture of CMC-Na and gelatin (1:1). This formulation can inhibit the growth of bacteria.

Conclusion: Several different types of gelling agents’ mixture for hand antiseptic gel preparation were made from the results of this study. It is necessary to develop a gel that can increase the antimicrobial activity of the active substance of citronella grass extract.
Adverse drug reaction of antiepileptic monotherapy on epileptic paediatric patients in Dr Sardjito Hospital, Yogyakarta, Indonesia
Authors: Harjaningsih Woro , Rahmania Emma , Firdha Sheila Nabila
Published: March 2022

Introduction: Epilepsy is a neurological disease with the highest prevalence in paediatrics. Using anti-epileptic drug as monotherapy is the first-line therapy for paediatrics based on risk-benefit ratio consideration in the patients effectiveness and adverse drug reaction of anti-epileptic monotherapy drug for the cognitive function in paediatric patients.   
Objectives: The aim of the study is to assess effectivity and adverse drug reaction of anti-epileptic monotherapy drug for the cognitive function in
paediatric patients.   
Methods: This was a cross sectional study. This study used patients from the Dr. Sardjito hospital’s outpatient paediatric unit’s Neurology division from May to July 2013 and May to June 2019 to select the subjects. Patient questionnaires and medical records provided the data that was used. Effectiveness was assessed by seizure severity with Hague Seizure Severity Scale (HASSS) questionnaire  and seizure frequency, while adverse drug reactions in cognitive function were assessed by the PESQ (Pediatric Epilepsy Side Effect Questionnaire) instrument.   
Results: In total, 29 patients received monotherapy, with 26 patients (89.66%) receiving valproate,  two (6.89%) receiving phenytoin, and one (3.45%) receiving phenobarbital. A total 89.66% of patients did not have severe seizures, but 6.90% had moderate seizures. The cognitive function of epileptic patients with co-morbidities receiving valproate monotherapy had moderate (27.59%) and severe (20.69%) side effects. The adverse drug reaction experienced in epileptic patients without co-morbidities using valproate was with the cognitive function, with 6.89% of patients experiencing severe effects, 13.79% moderate and 20.69% mild effects.    
Conclusion: While anti-epileptic monotherapy can control seizures in children, the commonly prescribed valproate can impair cognitive function, especially in those with co-morbidities.
Influence of dispersing solvent on curcumin dissolution from solid dispersions prepared using hydroxypropyl methylcellulose-polyvinylpyrrolidone K30
Authors: Setyaningsih Dewi , Palupi Dyah Roro , Hartini Yustina Sri
Published: March 2022

Background: Preparation of lipophilic compounds into solid dispersion formulations (SDs) has been credited with increasing their dissolution rate. Understanding the role of the dispersing solvent is crucial to the SDs preparation. Drug/carrier-solvent immiscibility may decrease the dissolution rate.

Aim: This work aimed to study the effect of different dispersing solvents on a curcumin dissolution.

Method: A solvent evaporation method was used in the SD preparation. The formulation was prepared at 30% w/w drug load contained Curcuma longa and a carrier mixture of Hydroxy Propyl Methylcellulose (HPMC)/ Polyvinylpyrrolidone K30 (PVP K30). As for the dispersing solvent, the study used ethanol, ethyl acetate, and ethanol/ethyl acetate solvent mixture. The dissolution profile was obtained and analysed for the dissolution-efficiency (DE).

Result: The DE values of 38.5%, 37.8%, and 32.0% were obtained using ethanol, ethyl acetate, and ethanol-ethyl acetate mixture.

Conclusion: The results show that there is a significant impact of using different SD solvents on curcumin dissolution.
White Turmeric (Kaempferia rotunda L.) extract liquid soap preparation for feminine hygiene and effectiveness against Candida albicans
Authors: Stiani Sofi Nurmay , Putri Lila Ardiani , Yusransyah  , Indriatmoko Dimas Danang
Published: March 2022

Background: Kaempferia rotunda L. (white turmeric) contains alkaloids, phenols, saponins, glycosides, steroids, terpenoids, and other ingredients with antimicrobial, anticancer, antiallergic, antioxidant, analgesic, and antifungal properties. Meanwhile, vaginal discharge or fluor albus is an excessive release of non-bloody fluid caused by the Candida albicans fungus.   
Objective: This study aimed to formulate white turmeric extracts (Kaempferia rotunda L.) into standard liquid soap for feminine hygiene and to determine the level of antifungal activity against Candida albicans.   
Methods: The liquid soap was produced by the maceration of white turmeric in 70% ethanol, which was evaporated until a thick extract was formed. This soap preparation included 7% stearic acid, 1% adeps lanae, 2% triethanolamine (TEA), 5% glycerol, white turmeric extract (at concentrations of 20%, 25%, and 30%), vanilla oil, and distilled water added up to 100 mL. Furthermore, the well method was used to test the antifungal activity of the preparations, and analysis was done on SPSS.   
Results: The results showed that the white turmeric ethanol extract was effective against the Candida albicans fungus at concentrations of 25% and 30%, with inhibitory diameters of 11 mm and 15 mm (categorised as powerful), respectively. Also, the liquid soap preparations of the extract revealed antifungal activity at a concentration of 30%, with a 9.6 mm inhibition diameter (medium category). The soap met Indonesian National Standard (SNI) requirements, including organoleptic, pH, high foam, and viscosity properties.    
Conclusion: The white turmeric ethanol extract can be formulated into a feminine hygiene soap with antifungal activity at a concentration of 30%.
Saudi Airlines Cabin Crew Performance Appraisal Using Artificial Intelligence - The Adaptive Neuro-Fuzzy Inference System
Authors: Abdulmajeed Eyad W.
Published: April 2022

This paper targets the application of artificial intelligence in improving and developing performance through the reduction of human error and the development of fair judgment in the performance of different activities. It focuses on Adaptive Neural Fuzzy Inference System (ANFIS) for the Saudi Airlines cabin crew. Among the findings of the research was that the training error is that the difference between the training data output value and the output of the fuzzy inference system and that the fuzzy linguistic variables are not clear when applied in the performance evaluation system. The study applied a case study to analyze an adaptive neural inference system and rate it to the impact it could create on the cabin crew. The study concluded that in conducting the performance appraisal of the employees some factors such as work goals, and information on the effectiveness of goals must be considered. Also, the lack of a formal reasoning mechanism supporting the inference and evaluations is a critical challenge in performance appraisal; hence, the application of artificial intelligence in the evaluation of the performance of employees in an organization could significantly impact the employees in working towards a common goal.
EFEKTIVITAS PEMBELAJARAN BIOLOGI MELALUI MODEL ARGUMENT DRIVEN INQUIRY TERHADAP KETERAMPILAN BERARGUMENTASI DAN HASIL BELAJAR SISWA
Authors: Mutiah Haerul , Ulfa Andi Yurni
Published: March 2022

Penelitian ini bertujuan untuk mengetahui efektivitas model pembelajaran Argument Driven Inquiry terhadap hasil belajar dan keterampilan berargumentasi siswa sebagai salah satu aspek penting dalam keterampilan proses sains. Jenis penelitian yang digunakan adalah Quasi Experimental (penelitian semu) dengan desain penelitian nonequivalent control group design. Hasil analisis menunjukkan bahwa keterampilan berargumentasi siswa pada kelas eksperimen jauh lebih tingi dibandingkan dengan siswa di kelas kontrol hal ini dibuktikan dengan masih terdapat 24% siswa di kelas kontrol yang belum mampu berargumen dengan baik sementara di kelas eksperimen hanya sekitar 4%. Hasil belajar Biologi yang diajar dengan model Argument Driven Inquiry (ADI) pada kelas eksperimen diperoleh rata-rata pretest 44,24 dengan kategori rendah sedangkan rata-rata nilai posttestnya yaitu 78,12 dengan kategori tinggi. Hasil belajar Biologi siswa yang diajar dengan model Non-ADI (kelas kontrol) diperoleh rata-rata nilai pretest sebesar 45,88 yang berada pada kategori rendah, sedangkan nilai posttestnya yaitu 68,16 dengan kategori cukup. Berdasarkan hasil analisis diperoleh nilai thitung= 2,03 > ttabel =0,03. Dari data tersebut ditarik kesimpulan bahwa terdapat perbedaan yang signifikan antara rata-rata hasil belajar Biologi  dan keterampilan berargumentasi siswa kelas eksperimen dan kelas kontrol. Hasil ini mengindikasikan bahwamodel pembelajaran Argument Driven Inquiry sangat efektif dalam mengembangkan keterampilan argumentasi siswa.
A percepção de um grupo de alunos sobre o contexto da educação remota
Authors: Lima Francisco Karisson Chagas , Silva Josefa Lúcia Morais
Published: March 2022

A proposta apresenta uma experiência de utilização das ferramentas de pesquisa acadêmica para realizar um estudo sobre a percepção dos alunos no aprendizado remoto: o que os alunos aprenderam? Se aprenderam? E como qualificam os aprendizados que estão tendo diante do contexto pandêmico? Para resolução das problemáticas apresentadas utilizamos a pesquisa quantitativa/qualitativa por meio de um formulário eletrônico com um universo representativo dos alunos que estão acompanhando as aulas de forma síncrona na instituição pesquisada. Para fundamentar os debates da pesquisa utilizamos o pensamento de autores como Amante, Cartoni e Costa sobre metodologias de ensino remoto e educação a distância. A partir das respostas foi possível refletir sobre as dificuldades de acesso que cada um enfrenta diante da realidade, e produzir conhecimento científico para debater o ensino-aprendizagem, bem como fortalecer a prática, conhecimento tecnológico, e como alunos e professores estão fazendo uso das habilidades e competências digitais.
Impact of I-GWO towards Trust based Resource Allocation in Collaborative Cloud
Authors: Pol Pooja , Pachghare Dr. Vinod K.
Published: April 2022

The cloud computing is arising as a popular computing paradigm, as it is good in offering its users an on-demand scalable resource based services over the internet. In the peak hours, a single cloud is not at all efficient in serving an application; therefore the collaborative cloud model has been introduced.  The collaborative cloud computing (CCC) make use of the globally-scattered distributed cloud resources of the diverse organizations collectively in a co-operative manner to provide the required service to the user. The allocation as well as the management of the resources is being a challenging task in the CCC, due to the heterogeneity of the resources. On the other hand, the assurance of the Quality of Service (QoS) and reliability of these resources is challenging. Further, it would be efficient if the resources are provided based on the system behavior. In this research work, a novel trust computing model is developed, which predicts both the QoS and Trust via analyzing the system behavior. The proposed model encloses three major phases: trust- QoS behavior estimation, resource matching and resource allocation. Initially, the QoS as well as Trust behavior of the system is estimated via a Neural Network (NN) model.  Subsequently, the resource allocation is performed using the parallel resource matching framework, which is based on the concept of Map-Reduce. More particularly, the precious resource allocation is achieved by an optimization logic called Improved Grey Wolf Optimizer (IGWO). Here, the improvement of GWO emphasis the consideration of both the best and worst fitness.
Exploring Secondary Schools Science Teachers Cognizance on TPACK in Technology Enhanced Learning during the 3rd Wave of Covid-19
Authors:   Training and Research Division SEAMEO RECSAM Penang, Malaysia, Khar Thoe Ng Nelson Cyril
Published: March 2022

Technology in education has become an important tool for teachers to disseminate or share their knowledge with students. Incorporating Content, Pedagogy and Knowledge (TPACK) skills can benefit teachers and studenrs in increasing their teaching and learning in this classroom. There were many studies done on teachers TPACK and their categorization but very few in the Malaysian context. This study aimed to explore the Malaysian context, in particular the state of Penang of Teachers TPACK on Technology Enhanced Learning (TEL) during the 3rd wave of the Covid-19 pandemic. This study employed a qualitative exploratory research design with sample of five teachers. The results indicated that TPACK on TEL discovered attributes that teachers revealed to enhance their teaching and learning processes and serves as an indicator on the types and use of technology in the classroom. The study could also provide information on teachers’ TPACK attributes in improving students grasping of science concepts. In the future these attributes can be extended and compared with pre-service teachers to give a better overview on teachers’ TPACK and their use of technology in education.
The Influence of Related Games on Improvement Teambuilding in Children with Disabilities in State SLB Sidomulyo South Lampung
Authors:   Lampung University, Tarigan Herman
Published: March 2022

The purpose of this study was to determine the effectiveness of the relay on improving the teambuilding of high class students with special needs at State SLB Sidomulyo South Lampung. The author uses a pre experimental design type of one group pretest – posttest design. It is said to be a pre experimental design, because this design is not yet a real experiment. With a population of 28 high school students, consisting of 7 deaf students, 17 mild mentally retarded, and 1 quadriplegic, and 3 blind students. Covers aspects of caring, responsibility, and cooperation. After the initial test, students are given relay training in accordance with the training program that has been made, then a final test is carried out. Based on data analysis, the t-count value is 14,702 and the t-table value (n-1) = (7-1) with a two-way test, = 0.05, the t-table value = 2.447. Because t count = 14,702 > t table = 2,447 it can be concluded that "Relay with relay running game is effective in improving the teambuilding of students with special needs in high class at State SLB Sidomulyo South Lampung".
Profit Distribution Management and Determinant Factors: Empirical Study on Sharia Commercial Bank in Indonesia
Authors:   Departement of Accounting, Universitas Muhammadiyah Purwokerto, Indonesia, Wahyuni Sri
Published: March 2022

Profit Distribution Management is critical for Islamic bank managers to ensure the banks they manage are sustainable. Profit Distribution Management will serve as the foundation for depositors' decision to invest in sharia banks. The study's overarching objective is to ascertain the level of profit distribution management at a sharia commercial bank and the factors that influence it. According to this study, the distinguishing characteristics of a sharia commercial bank that affect profit distribution management are capital adequacy, the percentage of third-party funds, and the age of the bank. While macroeconomic and Sharia Supervisory Board specific factors had no effect on the profit distribution management of a sharia commercial bank. This study made a significant contribution to the Islamic banking manager, Bank Indonesia, the Sharia Financial Accounting Standards Board, and the Islamic banking depositor.
Camarones, camaroneros y escasez hídrica: desafíos para la sostenibilidad pesquera de Cryphiops caementarius en la cuenca semiárida del río Choapa, Chile
Authors: Velásquez Gallardo Carlos , Alanís Yeriko , Torres-Avilés Denisse , Wilson Alvaro E. , Cárcamo P. Francisco
Published: April 2022

Cryphiops caementarius es un camarón anfídromo nativo de relevancia ecológica y pesquera en cuencas hidrográficas del norte de Chile. Esta especie representa un componente importante de la identidad cultural de las comunidades de camaroneros que subsisten de ella, otorgando servicios ecosistémicos para el bienestar social. Actualmente, las poblaciones se encuentran altamente amenazadas, principalmente por la escasez hídrica y modificación de hábitat producto de la peor sequía de los últimos 10 años en la zona centro-norte de Chile y la consecuente sobreexplotación de los recursos hídricos para usos humanos. Si bien existen medidas de administración vigentes para la actividad extractiva de camarones, como talla mínima de extracción y veda biológica, esta actividad no es reconocida formalmente por la institucionalidad pesquera nacional, existiendo desconocimiento de aspectos básicos de su funcionamiento, como la cantidad de camaroneros asociados, estado actual de sus poblaciones y sectores históricos de pesca. En este contexto, el objetivo principal del presente estudio fue caracterizar en conjunto con las organizaciones de camaroneros de la cuenca del río Choapa, el sistema socio-ecológico en cual subyace la pesquería de C. caementarius, durante el período 2019–2021, a través de: i) la recopilación del conocimiento tradicional de las organizaciones de camaroneros, ii) un seguimiento de la pesquería a través de registros recopilados por los camaroneros durante sus faenas de pesca, y iii) la construcción de un modelo conceptual basado en la percepción de los actores del sistema relacionados con la actividad camaronera local. A partir de estos resultados, se presentan recomendaciones para la implementación de plan(es) de conservación y manejo que apoye(n) la sostenibilidad de la pesquería de C. caementarius en la cuenca del río Choapa. Se discute una probable extinción local de sus poblaciones en la zona altitudinal alta de la cuenca y en ríos tributarios, y una posible conducta migratoria facultativa por la severa fragmentación y degradación del hábitat fluvial. Se concluye, que es necesario diseñar y desarrollar en conjunto con los actores sociales, acciones de conservación y manejo orientadas a apoyar la toma de decisiones locales y otorgar mayor resiliencia a la especie y a la pesquería en un contexto de gran vulnerabilidad ambiental dado el actual escenario de escasez hídrica que afecta a esta cuenca y a otras del norte de Chile.
Childhood Myelodysplastic Syndrome: A Rare Entity
Authors:   Department of Hematology, Chughtai Institute of Pathology, Lahore, Punjab, Pakistan, Fatima Mavra
Published: March 2022

Myelodysplastic syndrome (MDS) is a spectrum of bone marrow disorders resulting from clonal stem cell defect that manifest as cytopenias, ineffective hematopoiesis and dysplasia in all the three cell lines. Myelodysplastic syndrome is rare in children and accounts for less than 5% of the hematopoieitic malignancies below the age of 14 years. Refractory cytopenia of childhood (RCC) is the most common type of MDS that is seen in children. In this study, we report a case of 14 years old boy who presented to us with suspicion of aplastic anemia and was diagnosed as refractory cytopenia of childhood, a type of myelodysplastic syndrome.
Load Balancing Based on Many-objective Particle Swarm Optimization Algorithm with Support Vector Regression in Fog Computing
Authors:   Faculty of Computing and Information Technology, King Abdul Aziz University, Jeddah, JE, 21589 SA, Albalawi Mona , Alkayal Entisar ,   Faculty of Computing and Information Technology, King Abdul Aziz University, Jeddah, JE, 21589 SA
Published: April 2022

With the development in computing technologies, fog computing is developing as public and robust computing, which complements cloud computing to provide services, computation, and storage on the edge network. The future growth and support of 5G access networks additional advance the viability and implementation of fog networks and widen the scope of devices that can participate and serve in IoT communication. However, scaling fog computing, the number of end-users increases. Hence, the workload between fog nodes needs to be distributed efficiently. Otherwise, some of the nodes will be overloaded, and others will be under-loaded. Consequently, one of the critical factors for managing resources in fog computing efficiently and avoiding overloaded or under-loaded is load balancing. Therefore, load balancing between these resources is a challenge in fog computing. There are different techniques to balance the load, such as optimization algorithms or machine learning. This paper proposes a load balancing model in fog computing based on a many-objective particle swarm optimization (PSO) algorithm with support vector regression (SVR). The proposed load balancing model considered four metrics to optimize them while distributing the load: response time, energy consumption, resource utilization, and throughput. Besides, It combines SVR with PSO to improve PSO performance. The proposed model has been simulated and tested to evaluate the performance from different aspects. The experiments show that the proposed model efficiently balances the load with optimizing the four metrics. In addition, it improves the performance of PSO, which is used to balance the load.
Effect of Dual Polyphenolic Ingredient on Muscle Injury and Performance: A Prospective, Double-Blind, Placebo-Controlled, Randomized, Interventional Study in Healthy Volunteers
Authors:   ZeusHygia Life Sciences Pvt. Ltd., Hyderabad, India, Jeyakodi Shankaranarayanan , Bansal Kunal ,   Jehangir Clinical Development Centre Pvt. Ltd, Pune, India
Published: March 2022

Background: Eccentric exercise is a regular part of rehabilitation and sports training and to the unaccustomed, can cause muscle damage that presents as delayed soreness, strength and range of motion loss, swelling, and increased passive stiffness. These symptoms reduce exercise ability and might be harmful if exercise is further continued. In this study, we sought to test the efficacy of a proprietary dietary supplement, Gremin®, contains green coffee bean extract and curcumin in alleviating the severity of muscle damage and injury after standardized eccentric exercise. This study was a prospective, double-blind, placebo-controlled, randomized, interventional study. Sixteen healthy, moderately active, non-smoking volunteers with no known musculoskeletal pathology were enrolled. Mean differences within and between groups were assessed inferentially at each data collection point using t-tests for all outcome measures. Results: In this controlled study, the intake of Gremin® for 10 days resulted in a significant reduction in standardized measures of pain and tenderness at several post-eccentric exercise points compared to the placebo group. The Gremin® group had significantly reduced levels of plasma indicators of inflammation (C-reactive protein) and muscle damage (creatine kinase and lactate dehydrogenase), as well as standardized measures of pain and tenderness at several post-eccentric exercise time points, than the placebo group. Conclusions: Gremin® appears to be beneficial in accelerating the healing of acute muscle injury. Further studies with a larger sample size are warranted based on the current results.
The Emirates Oncology Task Force Clinical Practice Guideline on Screening for SARS-CoV-2 in Asymptomatic Adult Cancer Patients Prior to Anti-Cancer Therapy
Authors:   Department of Oncology–Burjeel Cancer Institute–Burjeel Medical City, Abu Dhabi, United Arab Emirates, Al-Shamsi Humaid
Published: March 2022

The Emirates Oncology Task Force Clinical Practice Guideline on Screening for SARS-CoV-2 in Asymptomatic Adult Cancer Patients Prior to Anti-Cancer Therapy Introduction: Cancer care during this pandemic is challenging given the competing risks of death from cancer versus death or serious complications from SARS- CoV-2 infection, and the likely higher lethality of COVID-19 in immunocompromised patients. Question remains on serial screening for SARSCoV-2 in asymptomatic adult cancer patients prior to anti-cancer therapy during the COVID-19 pandemic. Methods: We conducted a systematic review to formulate a consensus statement to guide the practising oncologists. Results: Most of the current guidelines recommends RT-PCR SARS-CoV-2 testing of asymptomatic patients prior to initiating and during the anti-cancer therapy despite the lack of robust evidence. We suggested the following: If screening is indicated in adult cancer patients, we recommend using RT-PCR over serum antibody or serum antigen for adult cancer patients; we also recommend assessing the risk of exposure to and infection from SARS-CoV-2 prior to each anti-cancer cycle, to consider SARS-CoV-2 in asymptomatic adult cancer patients prior to anti-cancer therapy in high risk groups : highly cytotoxic chemotherapy with potential profound neutropenia based on the physician’s risk assessment of the chemotherapy , stem cell transplantation. For asymptomatic intermediate-high risk cancer patients, we suggest performing RT-PCR 48-72 hours prior to initiating any anti-cancer therapy. For asymptomatic low-risk cancer patients, we suggest not to routinely screen prior to initiating any anti-cancer therapy (weak recommendation, low quality evidence). Conclusion: SARS-CoV-2 screening might be indicated with higher certainty to certain cancer risk groups. There remains a need for prospective trials to assess this intervention, and the outcome of such intervention. Current recommendations may change based on new and emerging evidence.
A Putative Quantum Transition in Zinc Atoms of Flavivirus Polymerase
Authors:   Anti-plague research institute of Rospoterbnadzor, 664047, Trilissera 78, Irkutsk, Russia, Potapova Uliana
Published: March 2022

Metal ions are coordinated in many proteins, and zinc ions are an obligatory attribute of several important protein families. Rna-dependent RNA polymerase (RdRp) in viruses of flavivirus genus contains two zinc atoms located in the two specific zinc binding sites. A reason which can explain a presence of zinc ions in the proteins is not as clear as for ions of another metals. A quantum transition in zinc ions is allowed and by a proposed suggestion it is utilized to arrange synchronous transformations of the coordinating proteins via a quantum entanglement. Molecular dynamics experiments which were conducted for flavivirus NS5 protein suggest that the conformation of the RdRp domain in NS5 is highly sensitive to the bond lengths between the zinc atoms and their four coordinating atoms. We hypothesize that a change of conformation is required for the functioning of the viral replicative complex and that it is the quantum transition in the zinc atoms which slightly changes the bond lengths; thus assisting the switch between the conformations. The deterministic induction of the transition in a virus replication can be explained by a quantum entanglement of the zinc atoms with some another quantum system.
Comparison of MRCP and ERCP findings: a retrospective secondary data analysis
Authors: Farman Ali  , Naveed Aamir  , Muhammad Kamran Hassan  , Fakhar-E-Alam  , Hashmat Ullah Khan  , Dilaram Khan
Published: April 2022

Objective: To compare the findings of magnetic resonance cholangiopancreatography and endoscopic retrograde cholangiopancreatographyin patients presenting with bile duct disorders.
Methodology: The retrospective secondary-data study was conducted at the Gastroenterology Department of Lady Reading Hospital, Peshawar, Pakistan,and comprised data of patients who presented with bile duct disordersfrom June2019 to May2020. Data was analysed using SPSS 25.
Results: Of the 92 patients, 41(44.6%) were males and 51(55.4%) were females. The overall mean age was 50.12 years with a standard deviation of 16.70 years (ranged: 13-80 years). Out of 28 bile duct calculi cases detected by endoscopic retrograde cholangiopancreatography, 25(89.3%) were detected by magnetic resonance cholangiopancreatography, and, of the 64 without calculi, it detected 50(78.1%). Out of 8 bile duct strictures detected by endoscopic retrograde cholangiopancreatography, 3(37.5%) were correctly diagnosed by magnetic resonance cholangiopancreatography, and, of the 84 unaffected patients, it excluded 79(94%). Out of 64 bile duct dilatation cases, magnetic resonance cholangiopancreatography correctly diagnosed 59(92.2%), and, of the 28 unaffected patients, it excluded 27(96.4%).
Conclusion: For bile duct stone and dilation, magnetic resonance cholangiopancreatography was found to have high diagnostic accuracy.
Key Words: Choledocholithiasis, Cholangiopancreatography, MRCP, ERCP.
Continuous...
NON-THERMAL PLASMA EFFECT OF LI DOPED NIO THIN FILMS PREPARED BY THE SPRAY PYROLYSIS TECHNIQUE FOR SENSOR APPLICATIONS226
Authors: MOHSIN Anaam N. , ADIL Ban H. , KHALEEL Hiba Q. , ANSARI Ramiz Ahmed Al- , SWADI Israa R.
Published: April 2022

In, this research, pure nickel oxide NiO and Lithium-nickel oxide NiO:Li films were prepared on to glass substrates at a temperature of 450°C, by using the spray pyrolysis technique to develop the gas sensor, utilizing nickel and lithium chlorides as precursors. The effect of non-thermal plasma at (3,5,7sec) on the structural, optical, and electrical properties for NiO:Li thin films were studied. XRD pattern shows all films are polycrystalline belonging to cubic structure and the intensity was around the plane of (111).In addition, using SEM images, all samples exhibit porous with nanoparticles in the range (16-33nm ) as size. Optical measurements revealed that pure NiO and NiO:Li films have direct energy gaps (Eg) and decrease (from 3.65eV to 3.60eV), respectively. The optical energy gap was reduced after exposure to non-thermal plasma for 3,5,7 seconds (3.50, 3.45, 3.30eV) respectively. The results of Hall effect showed that the electrical conductivity of all films were of the p-type. The gas sensing performance of the prepared films towards NO2 gas was studied at various working temperatures, including (RT, 100 oC, 200 oC, and 300 oC). The current study found that pure NiO and NiO:Li films deposited can detect nitrogen dioxide gas at low work temperatures, where showed pure NiO, NiO:Li films sensitivity towards nitrogen dioxide NO2 gas at an operating temperature RT about 26.1% , 36.8% respectively. After exposure to non-thermal plasma at (3,5,7sec), the sensor NiO:Li showed an increase in sensitivity, and the best sensitivity was towards NO2 gas at room temperature for the sample exposed to non-thermal plasma at (7 sec) (49.9 percent ). The same sample showed a maximum sensitivity towards NO2 gas at 200 oC about (80.2%) with moderate response and recovery time. The influence of non-thermal plasma leads to good sensing performance for NiO:Li films, as shown in the study.
Dampak Pandemi Covid Terhadap Pendapatan dan Kemiskinan Rumah Tangga UMKM Di DAS Keduang
Authors: Rahayu Endang Siti , Arbianti Arbianti
Published: March 2022

Covid-19 menimbulkan tantangan yaitu krisis kesehatan yang belum pernah terjadi sebelumnya di seluruh dunia, tidak terkecuali di Indonesia. Covid-19 telah menimbulkan dampak signifikan terhadap penurunan perekonomian nasional, termasuk sektor UMKM. Tujuan dari penelitian ini adalah mengetahui dampak pandemi Covid-19 terhadap pendapatan dan kemiskinan rumah tangga UMKM di DAS Keduang. Metode dasar dalam penelitian ini adalah deskriptif. Metode pengambilan sampel dilakukan secara purposive. Teknik pengumpulan data yang digunakan dalam penelitian ini yaitu wawancara menggunakan kuesioner terstruktur. Metode analisis data dalam penelitian ini menggunakan deskriptif komparatif dari pendapatan UMKM sebelum pandemi (2019) dan saat pandemi (2020). Analisis kemiskinan menggunakan Fosteer-Greer-Thorbecke (FGT) index. Hasil penelitian menunjukkan bahwa pandemi Covid-19 menimbulkan dampak terhadap penurunan pendapatan UMKM, peningkatan kedalaman kemiskinan, dan keparahan kemiskinan.
Evaluation of the genetic variant - 889 C > T Of Il-1α in migraine - partial analysis
Authors: Juliani Maria Paula Bertoletti , Rocha Amanda Brant , Zendrini Giovana Ortiz , Bello Valéria Aparecida , Poli-Frederico Poli-Frederico , Silva Aline Vitali da
Published: April 2022

IntroductionThe pathophysiology of migraine integrates inflammatory and genetic aspects, with interleukin-1α being a component of this picture. This pro-inflammatory cytokine, responsible for inducing pyrogenic, hematological, and metabolic phenomena, is produced by macrophages and monocytes. Genetic variants, which can be found in the regulatory region of the gene for this substance, have clinical implications in different systems.ObjectiveTo evaluate the frequency of the -889C>T genetic variant of IL-1α and its association with clinical variables related to migraine. MethodsProspective case-control study composed of migraine patients and healthy controls aged between 18 and 60 years of age. Project approved by the Research Ethics Committee of PUCPR (No. 3,029,972). Demographic, clinical data on migraine classification and characteristics were collected using a structured form and validated questionnaires on anxiety (STAIY2), depression (BDI) and migraine-related disability (MIDAS). Genetic evaluation was performed with blood or saliva samples that were subjected to polymerase chain reaction (PCR), followed by electrophoresis in 1.5% agarose gel. Categorical data were analyzed by chi-square test or Fisher's exact test and continuous data by t-test or Mann-Whitney test. ResultsA total of 156 participants, 73 migraineurs and 83 controls, were evaluated. The -889C>T variant of IL-1α was not associated with increased susceptibility to migraine when evaluated in allelic, codominant, dominant, or recessive models. The C allele, the lowest producer of the cytokine, was associated with a higher frequency of osmophobia in patients with migraine (65.5% vs. 48.2%; p=0.038). ConclusionNo association was identified between the -889C>T variant of IL-1α and susceptibility to migraine. Its effect on osmophobia should be further investigated. However, the present work is a partial analysis whose main limitation is the small sample size.
Hyperacusis in migraine: pilot project
Authors: Maistro Bruna , Machado Ana Clara Oliver , Bossa Beatriz Bagatim , Bello Valéria Aparecida , Poli Frederico Regina Célia , Silva Aline Vitali da
Published: April 2022

The stress caused by headache may be related to the development of hearing disorders, such as hyperacusis and phonophobia. Hyperacusis is an unpleasant sensation caused by exposure to a due reduction in your tolerance. Characterized by an increase in sound sensitivity via the auditory pathway and by the ability to hear. However, some few problems can occur, while others can even be from the intensity in case of elevation. Phonophobia is a common symptom and with migration criteria, without a diagnosis of hyperacusis was still little in this context. For this reason, a better understanding of hyperacusis corresponds to a new means for the management and diagnosis of migraine. Keywords: migraine, hyperacusis, phonophobia.
A Brazilian version of the headache management self-efficacy scale: A new instrument in the Portuguese language
Authors: Souza Mickael , Santiago Michelle Dias Santos , Santos Alcylene Carla de Jesus
Published: April 2022

Letter to the editor
Trigeminal neuralgia secondary to arteriovenous malformation in the brainstem: a case report and a brief review
Authors: Severo Bem Junior Luiz , Fechine de Alencar Neto Joaquim , Augusto Lustosa Nogueira Júlio , Sena Almeida Nivaldo , Rocha Cirne de Azevedo Filho Hildo
Published: April 2022

Trigeminal neuralgia, a condition characterized by high intensity, paroxysmal and unilateral pain, can be characterized as secondary when associated with conditions such as multiple sclerosis and tumors. However, among these secondary cases, there are also arteriovenous malformations, characterized by a nidus mass of vessels separated by parts of sclerotic tissues, responsible for a small portion of the neuralgias of the trigeminal nerve. The case report described is of a 54-year-old male patient who has a brainstem AVM and refers to lancing and paroxysmal pain in the right hemiface in the territories of V2 and V3 after feeding and brushing the teeth. The treatment of this patient was done from the insertion of a balloon from the foramen ovale, accessed by the Meckel fossa and the trigeminal ganglion. The literature review demonstrated, from the analysis of gender, age, vascularization, localization and treatments of reports of TGN secondary to brainstem AVM, the reduced number of cases described.
Fixed point results with respect to a wt-distance in partially ordered b-metric spaces and its application to nonlinear fourth-order differential equation
Authors: Babaei Reza , Rahimi Hamidreza , Soleimani Rad Ghasem
Published: April 2022

In this paper we study the existence of the fixed points for Hardy-Rogers type mappings with respect to a wt-distance in partially ordered metric spaces. Our results provide a more general statement, since we replace a w-distance with a wt-distance and ordered metric spaces with ordered b-metric spaces. Some examples are presented to validate our obtained results and an application to nonlinear fourth-order differential equation are given to support the main results.
Topological Krasner hyperrings with special emphasis on isomorphism theorems
Authors: Singha Manooranjan , Das Kousik
Published: April 2022

Krasner hyperring is one of the generalizations of the classical ring in literature. In this paper, the notion of topological Krasner hyperring is introduced as a generalization of topological ring and variant of isomorphism theorems are studied
Closed ideals in the functionally countable subalgebra of C(X)
Authors: Veisi Amir
Published: April 2022

In this paper, closed ideals in Cc(X), the functionally countable subalgebra of C(X), with the mc-topology, is studied. We show that ifX is CUC-space, then C*c(X) with the uniform norm-topology is a Banach algebra. Closed ideals in Cc(X) as a modified countable analogue of closed ideals in C(X) with the m-topology are characterized. For a zero-dimensional space X, we show that a proper ideal in Cc(X) is closed if and only if it is an intersection of maximal ideals of Cc(X). It is also shown that every ideal in Cc(X) with the mc-topology is closed if and only if X is a P-space if and only if every ideal in C(X) with the m-topology is closed. Moreover, for a strongly zero-dimensional space X, it is proved that a properly closed ideal in C*c(X) is an intersection of maximal ideals of C*c(X) if and only if X is pseudo compact. Finally, we show that if X is a P-space and F is an ec-filter on X, then F is an ec-ultrafilter if and only if it is a zc-ultrafilter.
Estado del arte de la educación en automática
Authors: Muñoz de la Peña David , Domínguez Manuel , Gomez-Estern Fabio , Reinoso Óscar , Torres Fernando , Dormido Sebastián
Published: April 2022

La educación en automática es un área madura en la que multitud de profesores e investigadores han trabajado intensamente para afrontar el reto de proporcionar una educación versátil, con una fuerte base cientí­fica. Todo ello sin perder de vista las necesidades de la industria; adaptando los contenidos, las metodologí­as y las herramientas a los continuos cambios sociales y tecnológicos de nuestro tiempo. Este artí­culo presenta una reflexión sobre el papel de la automática en la sociedad actual, una revisión de los objetivos tradicionales de la educación en automática a través de los trabajos seminales del área y finalmente una revisión de las principales tendencias actuales.
Validity and reliability of the Egyptian algometer in patients with bruxism
Authors: Ibrahim Mostafa M. , El-Gendy Mohamed H. , Helmy Emad S. , A. Hamada Hamada , Neamat Allah Neama H.
Published: March 2022

Introduction

Pressure pain threshold has been quantified by using a gold standard algometer in patients with bruxism. However, the expense associated with quantifying pressure pain threshold to detect trigger points with a gold standard algometer precludes its use in the clinic. This study aimed to measure the reliability and validity of the more accessible Egyptian algometer for pressure pain threshold evaluation in patients with bruxism.

Methods

A descriptive repeated-measures study was performed among 100 participants with bruxism. Pressure pain threshold values were collected from the left temporalis, right temporalis, left masseter, and right masseter muscles with the participants sitting. Pressure pain thresholds were assessed over 2 sessions separated by a 1-week interval.

Results

Intraclass correlation coefficient (ICC) determined the intra-rater reliability and Pearson correlation analysis determined the validity of the Egyptian algometer. ICC equalled 0.878, 0.785, 0.896, and 0.903 for the right masseter, left masseter, right temporalis, and left temporalis muscles, respectively. The standard error of measurement ranged from 0.24 to 0.5, the minimal detectable difference ranged from 0.66 to 1.41, ICC ranged from 0.785 to 0.903. Pearson correlation values were 0.673, 0.670, 0.408, and 0.705 for the right masseter, left masseter, right temporalis, and left temporalis muscles, respectively.

Conclusions

High ICCs indicated a strong agreement between the measurement systems, suggesting that the Egyptian algometer is a reliable and valid device for quantification of pressure pain threshold in patients with bruxism.
“Of All Type of Calidad or Color”
Authors: Farman Sweda Krystle
Published: April 2022

This chapter moves beyond the traditional depiction of black confraternities
as sites of distinct cultural community formation separate from
Spanish, indigenous, or mixed sacred organizations to argue that the
complex social relationships forged by persons of African descent within
the multiethnic colonial parish formed the foundation of their religious
communities. In the daily social interactions that occurred in the sacred
and secular spaces of the parish, black parishioners discussed their conceptions
of communal behavior with individuals of “all type of color or
calidad” – as the document studied in this chapter put it – fostering a sense
of Christian unity that emerged in the formation of confraternal orders.
Based on a shared spirituality framed by black expertise in Christian
practices, sacred communities functioned within the dynamic cultural
and social milieu of the colony, not as a distinct social organization, a
recognition that ultimately places black Catholics as the center of local
expressions of the Catholic faith.
Confraternal “Collections”
Authors: Gómez Ximena
Published: April 2022

Taking advantage of Lima’s rich documentary record, this chapter begins
the process of recovering the images, material culture, and devotional
interactions of black and indigenous confraternities that have been erased
by colonialism. I propose that if we consider each confraternity as a “collection,”
we can situate their documented sacred images and possession as
“inventory items” that were actively collected and thoughtfully displayed,
rather than objects that were passively owned. I argue that black and
indigenous confraternities curated their religious and social experiences
and, thereby, came to visually define the artistic religious landscape of
Lima in the sixteenth and seventeenth centuries.
African-Descent Women and the Limits of Confraternal Devotion in Colonial Lima, Peru
Authors: Walker Tamara J.
Published: April 2022

African-descent women played essential roles in confraternity life in
colonial Latin America. At the same time, however, confraternities often
imposed strictures on African-descent women by tying their place within
organizational hierarchies to their legal condition, marital status, and
ancestral makeup. The unfortunate, uncomfortable truth was that, no
matter how hard they worked or how much they sacrificed for confraternities,
there were limits to what African-descent women’s confraternal
devotion could yield them. But what alternatives did they have outside of
these institutions? To address this question, this chapter examines a small
collection of eighteenth-century records from Lima’s national archive that
feature inventories of material possessions belonging to free women of
African descent. Taken together, within and across each inventory, these
diverse devotional items provide an opportunity to think about Africandescent
women’s extra-confraternal devotional practices in colonial Lima.