bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of the Polymorphism of ISSR Markers in Spined Loaches of the Genus Cobitis (Cobitidae) in Connection with Problems of Differentiation of the Species Involved in the Formation of Polyploid Forms of Hybrid Origin and Determination of Their Taxonomic Status
Authors: Volkov A. A. , Rastorguev S. M. , Vasil’eva E. D. , Vasil’ev V. P.
Published: June 2023

We have analyzed the polymorphism of ISSR fragments of DNA by polymerase chain reaction in spined loaches for the first time. The analysis has made it possible to successfully differentiate the genomes, which were presumably involved in the formation of polyploid forms of hybrid origin: Cobitis taenia; spined loaches from the Danube River basin, which are diagnosed as C. elongatoides; C. tanaitica from the Don River basin and spined loaches from Lake Sinoe, which are also assigned to the species C. tanaitica by a number of authors. The following conclusions have been made based on comparative morphological studies of previously undifferentiated forms: (1) spined loaches from Central Europe with karyotype 2n = 50, NF = 96 correspond to the diagnosis of the species C. elongatoides; this species also differs from a number of closely related species and polyploid forms in the origin of the dorsal fin in front of the base of the pelvic fins, as well as in the presence of a spot in the lower half of the caudal fin base; (2) spined loaches from Lake Sinoe and other populations of Central Europe with karyotype 2n = 50, NF = 86 are nonconspecific to C. tanaitica and should apparently be ranked as an independent species, C. megaspila.
Effectiveness of internet-based and mobile-based interventions for adults with overweight or obesity experiencing symptoms of depression: a systematic review protocol
Authors: Schladitz Katja , Luppa Melanie , Riedel-Heller Steffi G , Loebner Margrit
Published: June 2023

Introduction

Internet-based and mobile-based interventions (IMIs) provide innovative low-threshold and cost-effective prevention and self-management options for mental health problems complementary to standard treatment. The objective of this systematic review is to summarise the effectiveness and to critically evaluate studies on IMIs addressing comorbid depressive symptoms in adults with overweight or obesity.

Methods and analysis

The study authors will systematically search the databases MEDLINE, Cochrane Library, PsycINFO, Web of Science, Embase and Google Scholar (for grey literature) for randomised controlled trials (RCTs) of IMIs for individuals with overweight or obesity and comorbid depressive symptoms without restrictions on publication date (planned inception 1 June 2023 to 1 December 2023). Two reviewers will independently extract and evaluate data from studies eligible for inclusion by assessing quality of evidence and qualitatively synthesising results. Preferred Reporting Items for Systematic reviews Meta-Analyses (PRISMA) standards and the revised Cochrane Risk of Bias tool in RCTs (RoB 2) will be applied.

Ethics and dissemination

Ethical approval is not required as no primary data will be collected. Study results will be disseminated through publication in a peer-reviewed journal and presentations on conferences.

PROSPERO registration number

CRD42023361771.
Cardiovascular disease risk among hypertensive patients and associated determinants in Addis Ababa, Ethiopia: an institutional-based cross-sectional study
Authors: Getahun Genanew Kassie , Goshu Bizunesh Yadeta , Goshu Dejuma Yadeta , Mekuria Zelalem Negash
Published: June 2023

Objective

The aim of this study was to assess the level of cardiovascular disease (CVD) risk and associated factors among hypertensive patients having follow-up at selected hospitals in Addis Ababa, Ethiopia, in 2022.

Setting

A hospital-based cross-sectional study was conducted in public and tertiary hospitals in Addis Ababa, Ethiopia, from 15 January 2022 to 30 July 2022.

Participants

A total of 326 adult hypertensive patients who visited the chronic diseases clinic for follow-up were included in the study.

Primary and secondary outcome measures

A high predicted 10-year CVD risk level was assessed using an interviewer-administered questionnaire and physical measurement (primary data) and reviews of medical data records (secondary data) by using a non-laboratory WHO risk prediction chart. Logistic regression with an adjusted OR (AOR) using a 95% CI was calculated for independent variables associated with 10-year CVD risk.

Results

The prevalence of a high predicted 10-year CVD risk level was 28.2% (95% CI 10.34% to 33.2%) among the study participants. A higher CVD risk level was found to be associated with age (AOR 4.2 for age 64–74, 95% CI 1.67 to 10.66), being male (AOR 2.1, 95% CI 1.18, 3.67), unemployment (AOR 3.2, 95% CI 1.06 to 6.25) and stage 2 systolic blood pressure (AOR 11.32; 95% CI 3.43 to 37.46).

Conclusion

The study showed that the respondent’s age, gender, occupation and high systolic blood pressure were determinant factors for CVD risks. Therefore, routine screening for the presence of CVD risk factors and assessment of CVD risk are recommended for hypertensive patients for CVD risk reduction.
Navigating role conflict: one professional’s journey as a new clinician leader
Authors: Wiedman Christopher
Published: June 2023

Transitioning from full-time clinical work to a leadership position can be a difficult transition for healthcare professionals. Competing demands, new responsibilities and changes in how one measures success in this new role often leave new clinician-leaders feeling lost, stymied or ineffectual.

Role conflict is one phenomenon which can impact a healthcare professional’s transition into leadership. Role conflict occurs when the clinician turned leader experiences a sense of dissonance between a highly valued identity as a clinician and a developing identity as a new leader.

This article shares my personal experience as a new clinician leader in the field of physical therapy. I offer reflections on the impact of professional role identity conflict during my transition into leadership, and how this role identity conflict led to early leadership failures, but also how addressing role conflict contributed to leadership success later on.

More importantly, this article offers advice to the new clinician leader for navigating role identity conflict during a clinical to leadership transition. This advice is based on my personal experience in physical therapy and on the growing body of evidence on this phenomenon in all healthcare professions.
Investigating the effects of impurity on electron mobility in quasi-one-dimensional wires
Authors: Bahrami Bahram , Kiamehr Zeynab , Sharafi Batol , Goodarzi Mojtaba
Published: June 2023

In this research, the electron mobility in GaAs quasi-one-dimensional wires with the presence of ionized impurity at zero temperatures was investigated and the results were compared with the mobility of a two-dimensional electron gas system. GaAs is a non-magnetic semiconductor with a direct band gap. Here for the calculations, the Boltzmann transport equation is used in the relaxation time approximation, taking into account the ionized impurity potential. Focusing on ionized Coulomb scattering and the short-range disorder is our goal. Electron mobility was investigated based on related parameters (Fermi energy and width of nanowires), and its diagram was drawn. In the end, the results of this research were compared with electron mobility in completely two-dimensional electronic systems. As expected, the numerical results showed that the electron mobility in extensive wires converges to the electron gas mobility of a fully two-dimensional plane.
Nonlinear sigma models in inflationary cosmology
Authors: Goswami Abhishek
Published: June 2023

Nonlinear Sigma Models in two dimensions ([Formula: see text]) describe the quantum-field theory (QFT) of the Embedding map from a two-dimensional surface to a higher dimensional target space. We assume that before the big bang the universe was an abstract space with a two-dimensional surface embedded in it. We study QFT of the Embedding map in the universe that is [Formula: see text]. We consider the abstract target space which is a Lie Group; SU(3) manifold. Then taking a symmetry breaking potential in [Formula: see text] QFT, we show the emergence of a geometric arrow of time via a big bang. This leads to an inflationary scenario driven by the Embedding map. We also discuss the mathematical existence of a [Formula: see text] and some aspects of the renormalization group flow in [Formula: see text] relevant to inflation.
Runtime Resource Management with Multiple-Step-Ahead Workload Prediction
Authors: Niknafs Mina , Eles Petru , Peng Zebo
Published: June 2023

Modern embedded platforms need sophisticated resource managers to utilize their heterogeneous computational resources efficiently. Furthermore, such platforms are subject to fluctuating workloads that are unforeseeable at design time. Predicting the incoming workload could enhance the efficiency of resource management in this situation. But is that the case? And, if so, how substantial is this improvement? Does multiple-step-ahead prediction of the workload contribute to this improvement? How precise must the prediction be to improve decisions rather than cause harm? By proposing a prediction-based resource manager that aims at meeting task deadlines while minimizing energy usage, and by conducting extensive tests, we attempt to provide answers to the aforementioned questions.
Marine Transgression in Modern Times
Authors: Hein Christopher J. , Kirwan Matthew L.
Published: June 2023

Marine transgression associated with rising sea levels causes coastal erosion, landscape transitions, and displacement of human populations globally. This process takes two general forms. Along open-ocean coasts, active transgression occurs when sediment-delivery rates are unable to keep pace with accommodation creation, leading to wave-driven erosion and/or landward translation of coastal landforms. It is highly visible, rapid, and limited to narrow portions of the coast. In contrast, passive transgression is subtler and slower, and impacts broader areas. It occurs along low-energy, inland marine margins; follows existing upland contours; and is characterized predominantly by the landward translation of coastal ecosystems. The nature and relative rates of transgression along these competing margins lead to expansion and/or contraction of the coastal zone and—particularly under the influence of anthropogenic interventions—will dictate future coastal-ecosystem response to sea-level rise, as well as attendant, often inequitable, impacts on human populations.
Exact Optical Solitons for Generalized Kudryashov’s Equation by Lie Symmetry Method
Authors: Ramaswamy Rajagopalan , El-Shazly E. S. , Abdel Latif M. S. , Elsonbaty Amr , Abdel Kader A. H.
Published: June 2023

In this article, we use Lie point symmetry analysis to extract some new optical soliton solutions for the generalized Kudryashov’s equation (GKE) with an arbitrary power nonlinearity. Using a traveling wave transformation, the GKE is transformed into a nonlinear second order ordinary differential equation (ODE). Using Lie point symmetry analysis, the nonlinear second-order ODE is reduced to a first-order ODE. This first-order ODE is solved in two cases to retrieve some new bright, dark, and kink soliton solutions of the GKE. These soliton solutions for the GKE are obtained here for the first time.
Improvement of Engineering Properties of Asphalt Binder and Mixture by Using SBS Additive Material
Authors: Mahmood Arian Omer , Kattan Raad Awad
Published: June 2023

Rutting, thermal cracking, and stripping are among the most severe distress types in asphalt pavement. In this study, a specified type of styrene-butadiene-styrene (SBS) was used as a modifier for a low viscosity asphalt binder G80/100 (PG 58-22) to overcome the issues of the distresses in the asphalt mixture. The mixing process had been evaluated by using fluorescent microscopy. The control- and SBS-modified binders were subjected to all conventional and Superpave binder tests. The Hamburg wheel tracker (HWT) and indirect tensile strength ratio (ITSR) tests were conducted to evaluate the engineering properties of the control and modified asphalt mixtures. The used SBS percentages were 1, 2, 3, 4, and 5% of the total weight of the binder. The results showed lower penetration, higher softening point, viscosity, and elastic recovery. The dynamic shear rheometer (DSR) and bending beam rheometer (BBR) tests showed an increasing SBS% leading to an increase in both values of high and low temperatures of the asphalt performance grade (PG). The tensile strength ratio and Hamburg wheel tracker tests’ results showed that the highest TSR and rutting parameter values were obtained at 3% SBS, which was the optimum SBS content for the asphalt mixture and the resulted modified asphalt is PG76-16.
Relay Node-Based Routing Algorithm for Reducing Latency in Industrial Mobile Communication Network
Authors: Hamatta Hatem S. A. , Basit Abdul , Sharada K. A. , Reddy Y. Venkateswara , Ragavan K. , Khan Mohiuddin Ali , Shukla Arvind Kumar , Kushwah Vivek Singh , Berhane Roviel
Published: June 2023

Mobile network nodes perform time transfer during data packet performance in an asynchronous manner. Network nodes get packets for transmission from node sensors that reject the demands of node attackers. When packet loss occurs unexpectedly due to a network removal, it is exceedingly difficult to detect assaults and time forwarding. Attack detection accuracy deteriorates, and packet loss rates rise. A strategy for node mobile intermediate that gets over attacks that identify the forward choosing is provided for improved data forwarding. Network performance is completely damaged by specific attacks, such as communication processes that degrade or lose packets. The algorithm’s architecture ensures that the best nodes are chosen for relaying and that transmission packets that do not drop are declined. To enable the node and create an effective path routing, a process is executed. Decreasing the amount of packet loss and increasing attack efficiency are being identified.
Inappropriate Protocol of Implant Placement in Contact with Impacted Teeth Leading to Failure
Authors: Ouni Imed , Mansour Lamia
Published: June 2023

Tooth impaction is a frequent phenomenon in patients with craniofacial syndrome, and the oral rehabilitation of such cases is considered a therapeutic challenge for the clinician. Placing implants in contact with impacted teeth may provide an alternative treatment for patients who refuse invasive surgery, and for whom orthodontic traction and surgery are not possible. However, the absence of evidence-based guideline protocols may sometimes lead to inappropriate execution by the clinician. This study aims to describe a case of early failure of an implant placed in contact with dental tissue and to identify the factors associated with implant failure to uncover and prevent their causative mechanisms.
Some Novel Optical Solutions for the Generalized
M
-Fractional Coupled NLS System
Authors: Hong Baojian , Zhou Jiaxin , Zhu Xingchen , Wang Yiting
Published: June 2023

In this work, some novel optical solutions for the (

1
+
1

)-dimensional generalized

M

-fractional coupled nonlinear Schrödinger system (GMFCNLS) arising in ocean engineering, plasma waves, and nonlinear optics have been investigated. After utilizing a modified (

G

′

/
G
,
1
/
G

)-expansion method and the

G

′

/

b

G

′

+
G
+
a

-expansion method, many types of novel optical solutions including the bell-shape soliton solutions, the blow-up solutions, the periodic wave solutions, and the mixed solitary wave solutions are obtained; if we select different values of wave velocity, coefficients, and orders, the dynamic properties and physical structures of these optical solutions are simulated and discussed, which can help us to further understand the inner structure of the system.
Quantitative Analysis of Postural Balance in Faller and Nonfaller Patients with Parkinson’s Disease
Authors: Kwon Do Young , Kwon Yuri , Choi Ji-An , Ko Junghyuk , Kim Ji-Won
Published: June 2023

Background. Postural instability has been identified as a fall risk factor with a significant impact on the quality of life of patients with Parkinson’s disease (PD). The aim of this study was to compare the center of pressure (COP) between faller and nonfaller patients with PD during static standing. Methods. Thirty-two faller patients and 32 nonfaller patients with PD participated in this study. All patients performed the static balance test on a force plate. COP data were recorded during quiet standing. Mean distance, sway area, mean velocity, mean frequency, and peak power were derived from the COP data. Statistical analysis was performed using independent t-tests to compare faller and nonfaller patients. Results. Fallers presented a greater average distance, wider sway area, faster average speed, and greater peak power than nonfallers (

p

 < 0.05). In contrast, no significant group differences were observed in peak frequency and mean frequency (

p

 > 0.05). Conclusions. Although falls occur during dynamic activities, our study demonstrated that even a safe and simple static postural balance test could significantly differentiate between faller and nonfaller patients. Thus, these results suggest that quantitatively assessed static postural sway variables would be useful for distinguishing prospective fallers among PD patients.
A Phase Ib, Open-label Study Evaluating the Safety and Efficacy of Ipatasertib plus Rucaparib in Patients with Metastatic Castration-resistant Prostate Cancer
Authors: Pook David , Geynisman Daniel M. , Carles Joan , de Braud Filippo , Joshua Anthony M. , Pérez-Gracia José Luis , Llácer Pérez Casilda , Shin Sang Joon , Fang Bruno , Barve Minal , Maruzzo Marco , Bracarda Sergio , Kim Miso , Kerloeguen Yannick , Gallo Jorge Daniel , Maund Sophia L. , Harris Adam , Huang Kuan-Chieh , Poon Victor , Sutaria Dhruvitkumar S. , Gurney Howard
Published: June 2023

Purpose:

To report the safety and efficacy of ipatasertib (AKT inhibitor) combined with rucaparib (PARP inhibitor) in patients with metastatic castration-resistant prostate cancer (mCRPC) previously treated with second-generation androgen receptor inhibitors.

Patients and Methods:

In this two-part phase Ib trial (NCT03840200), patients with advanced prostate, breast, or ovarian cancer received ipatasertib (300 or 400 mg daily) plus rucaparib (400 or 600 mg twice daily) to assess safety and identify a recommended phase II dose (RP2D). A part 1 dose-escalation phase was followed by a part 2 dose-expansion phase in which only patients with mCRPC received the RP2D. The primary efficacy endpoint was prostate-specific antigen (PSA) response (≥50% reduction) in patients with mCRPC. Patients were not selected on the basis of tumor mutational status.

Results:

Fifty-one patients were enrolled (part 1 = 21; part 2 = 30). Ipatasertib 400 mg daily plus rucaparib 400 mg twice daily was the selected RP2D, received by 37 patients with mCRPC. Grade 3/4 adverse events occurred in 46% (17/37) of patients, with one grade 4 adverse event (anemia, deemed related to rucaparib) and no deaths. Adverse events leading to treatment modification occurred in 70% (26/37). The PSA response rate was 26% (9/35), and the objective response rate per Response Criteria in Solid Tumors (RECIST) 1.1 was 10% (2/21). Median radiographic progression-free survival per Prostate Cancer Working Group 3 criteria was 5.8 months [95% confidence interval (CI), 4.0–8.1], and median overall survival was 13.3 months (95% CI, 10.9–not evaluable).

Conclusions:

Ipatasertib plus rucaparib was manageable with dose modification but did not demonstrate synergistic or additive antitumor activity in previously treated patients with mCRPC.
TABLE 3 from Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer
Authors: Xie Xuemei , Chauhan Gaurav B. , Edupuganti Ramakrishna , Kogawa Takahiro , Park Jihyun , Tacam Moises , Tan Alex W. , Mughees Mohd , Vidhu Fnu , Liu Diane D. , Taliaferro Juliana M. , Pitner Mary Kathryn , Browning Luke S. , Lee Ju-Hyeon , Bertucci François , Shen Yu , Wang Jian , Ueno Naoto T. , Krishnamurthy Savitri , Hortobagyi Gabriel N. , Tripathy Debu , Van Laere Steven J. , Bartholomeusz Geoffrey , Dalby Kevin N. , Bartholomeusz Chandra
Published: June 2023

Multicovariate Cox regression model for OS, PFS, and DMFS among patients with breast cancer (World IBC Consortium dataset; n = 314)
TABLE 1 from Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer
Authors: Xie Xuemei , Chauhan Gaurav B. , Edupuganti Ramakrishna , Kogawa Takahiro , Park Jihyun , Tacam Moises , Tan Alex W. , Mughees Mohd , Vidhu Fnu , Liu Diane D. , Taliaferro Juliana M. , Pitner Mary Kathryn , Browning Luke S. , Lee Ju-Hyeon , Bertucci François , Shen Yu , Wang Jian , Ueno Naoto T. , Krishnamurthy Savitri , Hortobagyi Gabriel N. , Tripathy Debu , Van Laere Steven J. , Bartholomeusz Geoffrey , Dalby Kevin N. , Bartholomeusz Chandra
Published: June 2023

Clinicopathologic characteristics of patients in the World IBC Consortium dataset whose data were used for our analysis (n = 314)
Supplementary Table S1 from Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer
Authors: Xie Xuemei , Chauhan Gaurav B. , Edupuganti Ramakrishna , Kogawa Takahiro , Park Jihyun , Tacam Moises , Tan Alex W. , Mughees Mohd , Vidhu Fnu , Liu Diane D. , Taliaferro Juliana M. , Pitner Mary Kathryn , Browning Luke S. , Lee Ju-Hyeon , Bertucci François , Shen Yu , Wang Jian , Ueno Naoto T. , Krishnamurthy Savitri , Hortobagyi Gabriel N. , Tripathy Debu , Van Laere Steven J. , Bartholomeusz Geoffrey , Dalby Kevin N. , Bartholomeusz Chandra
Published: June 2023

Supplementary Table S1. Full list of candidate regulators that were significantly enriched for 60 Reactome and WikiPathways, as identified by Affymetrix Genechip microarray analysis.
FIGURE 6 from Targeting Fatty Acid Reprogramming Suppresses CARM1-expressing Ovarian Cancer
Authors: Lombardi Simona , Goldman Aaron R. , Tang Hsin-Yao , Kossenkov Andrew V. , Liu Heng , Zhou Wei , Herlyn Meenhard , Lin Jianhuang , Zhang Rugang
Published: June 2023

SCD1 inhibition suppresses CARM1-expressing ovarian cancer in vivo. A, Schematic of experimental design for orthotopic xenograft ovarian cancer mouse model using A1847 cells. B and C, Reproductive tracts with tumors from the indicated treatment groups were dissected at the end of treatment (n = 5 mice per group; B). And the weights of tumors dissected from the indicated groups were measured as a surrogate for tumor burden (C). D and E, Same as B and C, but for syngeneic ovarian cancer mouse model using CARM1-expressing UPK10 cells (n = 5 mice per group). F and G, Tumors formed by A1847 cells treated with vehicle control or SCD1 inhibitor CAY10566 were subjected to IHC staining for the cell proliferative marker Ki67 and apoptotic marker cleaved caspase 3 (F), which was quantified on the basis of H score (G). N = 5 mice per group. Scale bars = 100 μm. Data represent mean ± SEM. P values were calculated using two-tailed t test.
Supplementary Figure S1 from Maternal Embryonic Leucine Zipper Kinase is Associated with Metastasis in Triple-negative Breast Cancer
Authors: Xie Xuemei , Chauhan Gaurav B. , Edupuganti Ramakrishna , Kogawa Takahiro , Park Jihyun , Tacam Moises , Tan Alex W. , Mughees Mohd , Vidhu Fnu , Liu Diane D. , Taliaferro Juliana M. , Pitner Mary Kathryn , Browning Luke S. , Lee Ju-Hyeon , Shen Yu , Wang Jian , Ueno Naoto T. , Krishnamurthy Savitri , Hortobagyi Gabriel N. , Tripathy Debu , Van Laere Steven J. , Bartholomeusz Geoffrey , Dalby Kevin N. , Bartholomeusz Chandra
Published: June 2023

Figure S1. Inhibitory effect of treatment with MELK-In-17 on the expression of epithelial-to-mesenchymal transition markers in murine 4T1 triple-negative breast cancer cells.
Genetic Diagnosis and Treatment of Inherited Renal Tubular Acidosis
Authors: Guo Wenkai , Ji Pengcheng , Xie Yuansheng
Published: June 2023

Background: Renal tubular acidosis (RTA) is caused by various disruptions to the secretion of H+ by distal renal tubules and/or dysfunctional reabsorption of HCO3− by proximal renal tubules, which causes renal acidification dysfunction, ultimately leading to a clinical syndrome characterized by hyperchloremic metabolic acidosis with a normal anion gap. With the development of molecular genetics and gene sequencing technology, inherited RTA has also attracted attention, and an increasing number of RTA-related pathogenic genes have been discovered and reported. Summary: This paper focuses on the latest progress in the research of inherited RTA and systematically reviews the pathogenic genes, protein functions, clinical manifestations, internal relationship between genotypes and clinical phenotypes, diagnostic clues, differential diagnosis, and treatment strategies associated with inherited RTA. This paper aims to deepen the understanding of inherited RTA and reduce the missed diagnosis and misdiagnosis of RTA. Key Messages: This review systematically summarizes the pathogenic genes, pathophysiological mechanisms, differential diagnosis, and treatment of different types of inherited RTA, which has good clinical value for guiding the diagnosis and treatment of inherited RTA.
Machine Learning for Prediction of Adverse Cardiovascular Events in Adults With Repaired Tetralogy of Fallot Using Clinical and Cardiovascular Magnetic Resonance Imaging Variables
Authors: Ishikita Ayako , McIntosh Chris , Hanneman Kate , Lee Myunghyun M. , Liang Tiffany , Karur Gauri R. , Roche S. Lucy , Hickey Edward , Geva Tal , Barron David J. , Wald Rachel M.
Published: June 2023

Background:

Existing models for prediction of major adverse cardiovascular events (MACE) after repair of tetralogy of Fallot have been limited by modest predictive capacity and limited applicability to routine clinical practice. We hypothesized that an artificial intelligence model using an array of parameters would enhance 5-year MACE prediction in adults with repaired tetralogy of Fallot.

Methods:

A machine learning algorithm was applied to 2 nonoverlapping, institutional databases of adults with repaired tetralogy of Fallot: (1) for model development, a prospectively constructed clinical and cardiovascular magnetic resonance registry; (2) for model validation, a retrospective database comprised of variables extracted from the electronic health record. The MACE composite outcome included mortality, resuscitated sudden death, sustained ventricular tachycardia and heart failure. Analysis was restricted to individuals with MACE or followed ≥5 years. A random forest model was trained using machine learning (n=57 variables). Repeated random sub-sampling validation was sequentially applied to the development dataset followed by application to the validation dataset.

Results:

We identified 804 individuals (n=312 for development and n=492 for validation). Model prediction (area under the curve [95% CI]) for MACE in the validation dataset was strong (0.82 [0.74–0.89]) with superior performance to a conventional Cox multivariable model (0.63 [0.51–0.75];
P
=0.003). Model performance did not change significantly with input restricted to the 10 strongest features (decreasing order of strength: right ventricular end-systolic volume indexed, right ventricular ejection fraction, age at cardiovascular magnetic resonance imaging, age at repair, absolute ventilatory anaerobic threshold, right ventricular end-diastolic volume indexed, ventilatory anaerobic threshold % predicted, peak aerobic capacity, left ventricular ejection fraction, and pulmonary regurgitation fraction; 0.81 [0.72–0.89];
P
=0.232). Removing exercise parameters resulted in inferior model performance (0.75 [0.65–0.84];
P
=0.002).

Conclusions:

In this single-center study, a machine learning-based prediction model comprised of readily available clinical and cardiovascular magnetic resonance imaging variables performed well in an independent validation cohort. Further study will determine the value of this model for risk stratification in adults with repared tetralogy of Fallot.
Preserving Trust: Strength of Contracts and Abuses of the Spanish Inquisition
Authors: Rosolino Riccardo
Published: June 2023

The impacts of the Spanish Inquisition in Sicily were manifold, affecting politics, business, and society. Those closely associated with the Inquisition could exercise the privilegium fori by having legal issues settled in the tribunal’s court by inquisitorial judges. Waiving this privilege could guarantee to other parties to a contract that their agreement could not be overruled by the tribunal. Waiving the right to the privilegium fori was institutionalized as such a guarantee to individuals contracting business in a society disciplined by different types of justice based on multiple legal systems.
Erythroxylum confertifolium, a new species from Chapada dos Veadeiros National Park, Goiás, Brazil, unveiled by morphology and leaf anatomy
Authors: SILVA MARCOS JOSÉ DA , IGOR SOARES DOS SANTOS
Published: June 2023

Erythroxylum confertifolium, a new species from the Chapada dos Veadeiros National Park, Goiás, Brazil, is described and illustrate here. It differs from E. campestre and E. parvistipulatum, its most similar congeners, by a set of morphological (e.g. branching appearance of the stem, leaf shape and consistency, numbers of setules of stipules and cataphylls, aspect of the pedicel, size of flower parts and fruits, and aspect of auricles of petals and styles), and leaf anatomical characters (e.g. number of main and accessory vascular bundles and their appearance on the petiole and midrib, aspect of the sheath that surrounds the vascular bundle, presence or absent of papillae, palisade parenchyma/spongy parenchyma ratio, presence or absence of sheath extension in vascular bundles, as well as composition of tissues of the cortex, and fibers types in midrib). Images, conservation assessments, and a distribution map of the new species are presented, as well as images for their morphologically correlated.
A new species of Calocybe (Agaricales, Basidiomycota) from China
Authors: MU LISONG , BAU TOLGOR
Published: June 2023

Morphological and molecular phylogenetic data were used to describe a new Calocybe species (C. violacea) collected from Yunnan Province, China. Calocybe violacea is characterized by its convex to applanate, purple to bluish-purple pileus; purple-black, bluish-purple to white stipe; and relatively larger basidiospores. Phylogenetic analyses of the combined ITS and nrLSU loci supported the distinct position of this proposed new species, showing that C. violacea clustered in a single sister clade with C. vinacea.
Thyrocarpus fujianensis (Boraginaceae; Cynoglosseae), a new species from China: evidence from morphological and molecular analyses
Authors: MA LIANG , CHEN XIN-YAN , CHEN YONG-BIN , ZHOU CHENG-YUAN , LIU MING-ZHU , CHEN SHI-PIN
Published: June 2023

We here describe and illustrate a new species, Thyrocarpus fujianensis (Boraginaceae), from Fujian Province in southern China. Morphological comparisons indicated that T. fujianensis is similar to T. sampsonii and T. glochidiatus but displays distinct differences in habitat, leaves, pedicel, calyx, corolla and fruit. Phylogenetic analysis based on the nuclear (ITS) and two plastid DNA sequences (rps16 and trnL–trnF) showed that T. fujianensis is nested within Thyrocarpus with relatively strong supporting values but only weak support as sister to T. sampsonii. The morphological and molecular evidence both support the status of T. fujianensis as a new species.
Assemblages of Trichoptera larvae on water moss in the middle reaches of the Yenisei River (Siberia, Russia)
Authors: KONOVALOVA DARIA A. , KISLITSINA NADEZHDA I. , ZOTINA TATIANA A.
Published: June 2023

This study provides first data on species composition of trichopterans inhabiting water moss, Fontinalis antipyretica Hedw., in the middle reaches of the Yenisei River. Analysis of Trichoptera larvae collected from samples of water moss in tail waters of the Krasnoyarsk Hydroelectric Plant in 2008–2021 revealed nine species of the order, which belonged to four families. Among them, six species belonging to the Limnephilidae family have not been mentioned in previous studies of the Yenisei invertebrates. Images of species are provided. One species, Apatania crymophyla McLachlan, was the most dense in all samples of water moss. The densities of A. crymophyla in samples of water moss in 2021 ranged within 1.2–7.0 thousand individuals / kg f.w. Other representatives of the order occurred in samples of water moss sporadically or consistently but in very low densities, which did not allow reliable quantification of their abundances. Consequently, numerous large clumps of water moss in the fast-flowing waters of the Yenisei favor an abundance of Trichoptera larvae, providing these insects refuge, food, and material for their cases. However, the reasons for the predominance of one species, A. crymophyla, are to be elucidated in further studies. The present study suggests that the contributions of Trichoptera and the total invertebrate community inhabiting water moss to biomass and energy budgets in the Yenisei have been usually underestimated before now. Hence, seasonal trends of species composition and abundance of invertebrates associated with water moss in the Yenisei River, including comparison with the entire zoobenthic community, are to be studied in the future.
Anthrenus (Anthrenus) mumbaiensis sp. nov. from India and a morphometric examination of Anthrenus (Anthrenus) festivus (Coleoptera, Dermestidae, Anthrenini)
Authors: HOLLOWAY GRAHAM J.
Published: June 2023

All examples of Anthrenus (Anthrenus) festivus were borrowed from the Natural History Museum, London for dissection to provide good images of external and internal features. Images of habitus, ventrites and antennae are presented along with aedeagus and sternite IX. The purpose of this was to provide clear information for future comparative taxonomic studies. During the examination of the specimens, a new species was discovered that had been collected in Bombay (Mumbai) in the late 19th century. Images of external and internal features of the holotype (male) and paratype (female) are provided. The new species is named Anthrenus (Anthrenus) mumbaiensis after the location of collection. Collection data from the study specimens, Andreas Herrmann’s private collection, the literature, and verifiable images on iNaturalist were used to generate a distribution map. The map showed that A. festivus is found mainly in coastal regions of the western Mediterranean.
Understanding Everyday Travel Experiences and Transportation Infrastructure Challenges of People with Disabilities in Denver, CO
Authors: Wagner Molly , Shirgaokar Manish , Marshall Wesley
Published: June 2023

A common perception is that the transportation experiences of people with disabilities have improved dramatically since the passing of the Americans with Disabilities Act (ADA) in 1990. Though much progress has been made, many aspects of the current transportation system still limit people with disabilities from traveling safely and efficiently. Moreover, transportation planning and design efforts consistently lack representation of people with disabilities. This research seeks to address this disconnect via semi-structured interviews with (i) 28 stakeholders who self-identify as having a disability; and (ii) 9 government officials whose work intersects with the supply of infrastructure regulated under the ADA. All interviewees reside or work in the Denver region in Colorado. One objective is to understand how attributes of transportation infrastructure affect the daily mobility of people with disabilities. A second is to comprehend how the programming and management of transportation assets affects navigation for people with disabilities. Through a thematic and content analysis of the interview corpus, we reveal the challenges faced by people with disabilities through hard infrastructure issues and the programming or management of transportation facilities. Together, these act to diminish the quality of mobility options for people with disabilities. When working to create a transportation network that is universally accessible, it is critical for planners and engineers to work with people with disabilities when considering the design needs of individuals with different types of disabilities.
Genomic landscape of TP53-mutated myeloid malignancies
Authors: Abel Haley J. , Oetjen Karolyn A. , Miller Christopher A. , Ramakrishnan Sai M. , Day Ryan B. , Helton Nichole M. , Fronick Catrina C. , Fulton Robert S. , Heath Sharon E. , Tarnawsky Stefan P. , Nonavinkere Srivatsan Sridhar , Duncavage Eric J. , Schroeder Molly C. , Payton Jacqueline E. , Spencer David H. , Walter Matthew J. , Westervelt Peter , DiPersio John F. , Ley Timothy J. , Link Daniel C.
Published: June 2023

TP53-mutated myeloid malignancies are associated with complex cytogenetics and extensive structural variants, which complicates detailed genomic analysis by conventional clinical techniques. We performed whole-genome sequencing (WGS) of 42 acute myeloid leukemia (AML)/myelodysplastic syndromes (MDS) cases with paired normal tissue to better characterize the genomic landscape of TP53-mutated AML/MDS. WGS accurately determines TP53 allele status, a key prognostic factor, resulting in the reclassification of 12% of cases from monoallelic to multihit. Although aneuploidy and chromothripsis are shared with most TP53-mutated cancers, the specific chromosome abnormalities are distinct to each cancer type, suggesting a dependence on the tissue of origin. ETV6 expression is reduced in nearly all cases of TP53-mutated AML/MDS, either through gene deletion or presumed epigenetic silencing. Within the AML cohort, mutations of NF1 are highly enriched, with deletions of 1 copy of NF1 present in 45% of cases and biallelic mutations in 17%. Telomere content is increased in TP53-mutated AMLs compared with other AML subtypes, and abnormal telomeric sequences were detected in the interstitial regions of chromosomes. These data highlight the unique features of TP53-mutated myeloid malignancies, including the high frequency of chromothripsis and structural variation, the frequent involvement of unique genes (including NF1 and ETV6) as cooperating events, and evidence for altered telomere maintenance.
Assessing competence needs for doctors in the emergency department duty rosters: an observational study
Authors: Kolnes Johannes , Hodneland Erlend , Lange Audun , Heggestad Torhild
Published: June 2023

Background

The purpose of our investigation is to analyze if emergency epidemiology is randomly variable or predictable. If emergency admissions show a predictable pattern, we can use it for multiple planning purposes, especially defining competence needs for duty roster personnel.

Method

An observational study of consecutive emergency admissions at Haukeland University Hospital in Bergen over six years. We extracted the discharge diagnoses from our electronic patient record and sorted the patients by diagnoses and frequency. Data were loaded into a Jupyter notebook and presented in form of frequency diagrams.

The study population, 213,801 patients, comprises all emergency admissions in need of secondary emergency care from the relevant specialities in the catchment area of our hospital in the western health region of Norway. Patients in need of tertiary care from the whole region are also included.

Results

Our analysis shows an annually reproducible distribution pattern regarding type and number of patients. The pattern adhere to an exponential curve that is stable from year to year. An exponential distribution pattern also applies when we sort patients according to the capital letters groups in the ICD 10 system. The same applies if patients are sorted adhering to primarily surgical or medical diagnoses.

Conclusion

Analysis of the emergency epidemiology of all admitted emergency patients in a defined geographical area gives a solid basis for defining competence needs for duty roster work.
Single-rater reliability of a three-dimensional instrument for decision-making in tertiary triage and ICU- prioritization—a case vignette simulation study
Authors: Bushuven Stefan , Bentele Michael , Gerber Bianka , Michalsen Andrej , Ilkilic Ilhan , Inthorn Julia
Published: June 2023

Disconcerting reports from different EU countries during the first wave of the COVID-19 pandemic demonstrated the demand for supporting decision instruments and recommendations in case tertiary triage is needed. COVID-19 patients mainly present sequentially, not parallelly, and therefore ex-post triage scenarios were expected to be more likely than ex-ante ones. Decision-makers in these scenarios may be highly susceptible to second victim and moral injury effects, so that reliable and ethically justifiable algorithms would have been needed in case of overwhelming critical cases.

To gather basic information about a potential tertiary triage instrument, we designed a three-dimensional instrument developed by an expert group using the Delphi technique. The instrument focused on three parameters: 1) estimated chance of survival, 2) estimated prognosis of regaining autonomy after treatment, and 3) estimated length of stay in the ICU. To validate and test the instrument, we conducted an anonymous online survey in 5 German hospitals addressing physicians that would have been in charge of decision-making in the case of a mass infection incident. Of about 80 physicians addressed, 47 responded. They were presented with 16 fictional ICU case vignettes (including 3 doublets) which they had to score using the three parameters of the instrument.

We detected a good construct validity (Cronbach’s Alpha 0.735) and intra-reliability (p < 0.001, Cohens Kappa 0.497 to 0.574), but a low inter-reliability (p < 0.001, Cohen’s Kappa 0.252 to 0.327) for the three parameters. The best inter-reliability was detected for the estimated length of stay in the ICU. Further analysis revealed concerns in assessing the prognosis of the potentially remaining autonomy, especially in patients with only physical impairment.

In accordance with German recommendations, we concluded that single-rater triage (which might happen in stressful and highly resource-limited situations) should be avoided to ensure patient and health care provider safety. Future work should concentrate on reliable and valid group decision instruments and algorithms and question whether the chance of survival as a single triage parameter should be complemented with other parameters, such as the estimated length of stay in the ICU.
Essential information for neurorecovery clinical trial design: trajectory of global disability in first 90 days post-stroke in patients discharged to acute rehabilitation facilities
Authors: Taleb Shayandokht , Lee Jenny Ji-hyun , Duncan Pamela , Cramer Steven C. , Bahr-Hosseini Mersedeh , Su Michael , Starkman Sidney , Avila Gilda , Hochberg Arielle , Hamilton Scott , Conwit Robin A. , Saver Jeffrey L.
Published: June 2023

Background

Many stroke recovery interventions are most beneficial when started 2-14d post-stroke, a time when patients become eligible for inpatient rehabilitation facilities (IRF) and neuroplasticity is often at its peak. Clinical trials focused on recovery need to expand the time from this plasticity to later outcome timepoints.

Methods

The disability course of patients with acute ischemic stroke (AIS) and intracranial hemorrhage (ICH) enrolled in Field Administration of Stroke Therapy Magnesium (FAST-MAG) Trial with moderate-severe disability (modified Rankin Scale [mRS] 3–5) on post-stroke day4 who were discharged to IRF 2-14d post-stroke were analyzed.

Results

Among 1422 patients, 446 (31.4%) were discharged to IRFs, including 23.6% within 2-14d and 7.8% beyond 14d. Patients with mRS 3–5 on day4 discharged to IRFs between 2-14d accounted for 21.7% (226/1041) of AIS patients and 28.9% (110/381) of ICH patients, (p < 0.001). Among these AIS patients, age was 69.8 (± 12.7), initial NIHSS median 8 (IQR 4–12), and day4 mRS = 3 in 16.4%, mRS = 4 in 50.0%, and mRS = 5 in 33.6%. Among these ICH patients, age was 62.4 (± 11.7), initial NIHSS median 9 (IQR 5–13), day 4 mRS = 3 in 9.4%, mRS = 4 in 45.3%, and mRS = 5 in 45.3% (p < 0.01 for AIS vs ICH). Between day4 to day90, mRS improved ≥ 1 levels in 72.6% of AIS patients vs 77.3% of ICH patients, p = 0.3. For AIS, mRS improved from mean 4.17 (± 0.7) to 2.84 (± 1.5); for ICH, mRS improved from mean 4.35 (± 0.7) to 2.75 (± 1.3). Patients discharged to IRF beyond day14 had less improvement on day90 mRS compared with patients discharged between 2-14d.

Conclusions

In this acute stroke cohort, nearly 1 in 4 patients with moderate-severe disability on post-stroke day4 were transferred to IRF within 2-14d post-stroke. ICH patients had nominally greater mean improvement on mRS day90 than AIS patients. This course delineation provides a roadmap for future rehabilitation intervention studies.
Schizotypal traits in a large sample of high-school and university students from Tunisia: correlates and measurement invariance of the arabic schizotypal personality questionnaire across age and sex
Authors: Fekih-Romdhane Feten , Hakiri Abir , Stambouli Manel , Cherif Wissal , Away Rami , Amri Amani , Cheour Majda , Hallit Souheil
Published: June 2023

Background

The main goal of the present study was to examine the characteristics of schizotypal traits and their correlations with genetic (i.e., family history of mental illness), demographic (i.e., age, sex), environmental (e.g., income, urbanicity, tobacco/alcohol/cannabis use), and psychological (i.e., personal history of mental illness other than psychosis) factors in Tunisian high-school and university students. Our secondary goal was to contribute the literature by examining the factor structure and factorial invariance of the Arabic Schizotypal Personality Questionnaire (SPQ) across sex and age (adolescents [12–18 years] vs. young adults [18–35 years]) groups.

Method

This was a cross-sectional study involving 3166 students: 1160 (36.6%) high-school students (53.0% females, aged 14.9 ± 1.8); and 2006 (63.4%) university students (63.9% females, aged 21.8 ± 2.3). All students were asked to complete a paper-and-pencil self-administered questionnaire containing sociodemographic characteristics as well as the Arabic version of the SPQ.

Results

The total sample yielded total SPQ scores of 24.1 ± 16.6 out of 74. The SPQ yielded good composite reliability as attested by McDonald's omega values ranging from .68 to .80 for all nine subscales. Confirmatory Factor Analysis indicated that fit of the 9-factor model of SPQ scores was acceptable. This model is invariant (at the configural, metric and structural levels) across sex and age. Except for “Odd or eccentric behavior”, all schizotypy features were significantly higher among female students compared to males. Multivariable analyses showed that female sex, being a university student, lowest family incomes, tobacco use, and having a personal history of psychiatric illness were significantly associated with higher positive, negative and disorganized schizotypy subscales scores.

Conclusion

Future research still needs to confirm our findings and investigate the contribution of the identified factors in the development of clinical psychosis. We can also conclude that the Arabic SPQ is appropriate for measuring and comparing schizotypy across age and sex in clinical and research settings. These findings are highly relevant and essential for ensuring the clinical utility and applicability of the SPQ in cross-cultural research.