bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparing different data sources by examining the associations between surrounding greenspace and children's weight status
Authors: Zhou Yusheng , von Lengerke Thomas , Dreier Maren
Published: May 2021

Background

Studies on the association between surrounding greenspace and being overweight in childhood show inconsistent results, possibly because they differ widely in their definition and measurement of surrounding greenspace. Our aim was to evaluate whether the association of greenspace with being overweight depends on the measurement of greenspace in different data sources.

Methods

Based on data from the school entry examinations of 22,678 children in the city of Hannover, Germany, from 2010 to 14, the association between greenspace availability and overweight was examined. Three different sources of greenspace availability were derived for a set of 51 areas of the city: The Normalized Difference Vegetation Index (NDVI), the OpenStreetMap (OSM) dataset, and the European Urban Atlas (UA) dataset. Agreement between the indicators on the quantity of greenspace coverage was compared. The association with children's BMI z-score, including potential interaction terms, was assessed using multilevel regression analysis.

Results

Greenspace availability per district area derived by NDVI was on average 42%, by OSM 29% and UA 22%, with OSM and UA being strongly correlated. Only the greenspace availability derived by NDVI showed an association with children's BMI z-score: The higher the greenspace availability was, the lower the BMI. The trend of association was higher for boys and migrant children than for girls and non-migrants and was restricted to the highest levels of greenspace availability.

Conclusions

Associations of greenspace with children's weight status depend on the greenspace measurement chosen. Surrounding greenspace was measured more comprehensively by NDVI. Data sources based on land use categories such as UA and OSM may be less suitable to reflect surrounding greenspace relevant for health outcomes. Potential mechanisms warrant further analysis and investigation.
How prevalent are symptoms and risk factors of pelvic inflammatory disease in a sexually conservative population
Authors: Al-kuran Oqba , Al-Mehaisen Lama , Alduraidi Hamza , Al-Husban Naser , Attarakih Balqees , Sultan Anas , Othman Zeina , AlShárat Sanal , AlHilali Shoug , Alkouz Nadia , Alibrahim Noura , AlMusallam Wafaa
Published: May 2021

Background

Pelvic inflammatory disease (PID) is the inflammation of the adnexa of the uterus, that mainly manifests in a subclinical/chronic context and goes largely underreported. However, it poses a major threat to women’s health, as it is responsible for infertility and ectopic pregnancies, as well as chronic pelvic pain. Previous studies in Jordan have not reported PID, attributed mainly to the social structure of the country which largely represents a sexually conservative population. Our study aims to report the clinical symptoms that point towards PID and investigate the major risk determinants for the Jordanian population, in a cross-sectional study, using our scoring system based only on clinical data and examination.

Methods

One hundred sixty-eight consecutive adult women that came in the Outpatient Clinics of Gynaecological Department of the Jordan University Hospital were interviewed and their medical history and symptoms were registered and analysed. A Score for PID symptoms, we developed, was given to each woman. Results and correlations were then statistically tested.

Results

Our study population consisted of relatively young women (37.7 ± 11) that had their first child at an average age of 24.1 (± 4.8) and a mean parity of 3.1 (± 2.2). Fifty-eight women (34.5%) reported having undergone at least one CS, while the mean PID Symptom Score was 3.3 (± 2.3). The women in our study exhibited 8 symptoms of PID, namely dysmenorrhea and vaginal discharge; being the commonest (45.2% and 44.6% respectively), in addition to chronic pelvic pain, pelvic heaviness, menorrhagia, dyspareunia, urinary symptoms, and smelly urine. They also reported history of 3 conditions that can be attributed to PID, that is infertility, preterm labour, and miscarriages.

Conclusions

Our PID Scoring System seems to identify the risk factors of PID and predict well the PID likelihood. This score predicts that women with higher parity, who used contraceptives and underwent any invasive medical procedure are expected to score higher in the PID Symptom Score. Our data also suggest that PID should not be ruled out in the Jordanian population when symptoms are compatible to this diagnosis.
The epidemiology of chronic ankle instability with perceived ankle instability‐ a systematic review
Authors: Lin Chiao‐I , Houtenbos Sanne , Lu Yu‐Hsien , Mayer Frank , Wippert Pia‐Maria
Published: May 2021

Background

Chronic ankle instability, developing from ankle sprain, is one of the most common sports injuries. Besides it being an ankle issue, chronic ankle instability can also cause additional injuries. Investigating the epidemiology of chronic ankle instability is an essential step to develop an adequate injury prevention strategy. However, the epidemiology of chronic ankle instability remains unknown. Therefore, the purpose of this study was to investigate the epidemiology of chronic ankle instability through valid and reliable self‐reported tools in active populations.

Methods

An electronic search was performed on PubMed and Web of Science in July 2020. The inclusion criteria for articles were peer‐reviewed, published between 2006 and 2020, using one of the valid and reliable tools to evaluate ankle instability, determining chronic ankle instability based on the criteria of the International Ankle Consortium, and including the outcome of epidemiology of chronic ankle instability. The risk of bias of the included studies was evaluated with an adapted tool for the sports injury review method.

Results

After removing duplicated studies, 593 articles were screened for eligibility. Twenty full‐texts were screened and finally nine studies were included, assessing 3804 participants in total. The participants were between 15 and 32 years old and represented soldiers, students, athletes and active individuals with a history of ankle sprain. The prevalence of chronic ankle instability was 25%, ranging between 7 and 53%. The prevalence of chronic ankle instability within participants with a history of ankle sprains was 46%, ranging between 9 and 76%. Five included studies identified chronic ankle instability based on the standard criteria, and four studies applied adapted exclusion criteria to conduct the study. Five out of nine included studies showed a low risk of bias.

Conclusions

The prevalence of chronic ankle instability shows a wide range. This could be due to the different exclusion criteria, age, sports discipline, or other factors among the included studies. For future studies, standardized criteria to investigate the epidemiology of chronic ankle instability are required. The epidemiology of CAI should be prospective. Factors affecting the prevalence of chronic ankle instability should be investigated and clearly described.
Accuracy of pancreatic stone protein for the diagnosis of infection in hospitalized adults: a systematic review and individual patient level meta-analysis
Authors: Prazak Josef , Irincheeva Irina , Llewelyn Martin J. , Stolz Daiana , García de Guadiana Romualdo Luis , Graf Rolf , Reding Theresia , Klein Holger J. , Eggimann Philippe , Que Yok-Ai
Published: May 2021

Background

Accurate biomarkers to diagnose infection are lacking. Studies reported good performance of pancreatic stone protein (PSP) to detect infection. The objective of the study was to determine the performance of PSP in diagnosing infection across hospitalized patients and calculate a threshold value for that purpose.

Methods

A systematic search across Cochrane Central Register of Controlled Trials and MEDLINE databases (1966–March 2019) for studies on PSP published in English using ‘pancreatic stone protein’, ‘PSP’, ‘regenerative protein’, ‘lithostatin’ combined with ‘infection’ and ‘sepsis’ found 44 records. The search was restricted to the five trials that evaluated PSP for the initial detection of infection in hospitalized adults. Individual patient data were obtained from the investigators of all eligible trials. Data quality and validity was assessed according to PRISMA guidelines. We choose a fixed-effect model to calculate the PSP cut-off value that best discriminates infected from non-infected patients.

Results

Infection was confirmed in 371 of 631 patients. The median (IQR) PSP value of infected versus uninfected patients was 81.5 (30.0–237.5) versus 19.2 (12.6–33.57) ng/ml, compared to 150 (82.70–229.55) versus 58.25 (15.85–120) mg/l for C-reactive protein (CRP) and 0.9 (0.29–4.4) versus 0.15 (0.08–0.5) ng/ml for procalcitonin (PCT). Using a PSP cut-off of 44.18 ng/ml, the ROC AUC to detect infection was 0.81 (0.78–0.85) with a sensitivity of 0.66 (0.61–0.71), specificity of 0.83 (0.78–0.88), PPV of 0.85 (0.81–0.89) and NPV of 0.63 (0.58–0.68). When a model combining PSP and CRP was used, the ROC AUC improved to 0.90 (0.87–0.92) with higher sensitivity 0.81 (0.77–0.85) and specificity 0.84 (0.79–0.90) for discriminating infection from non-infection. Adding PCT did not improve the performance further.

Conclusions

PSP is a promising biomarker to diagnose infections in hospitalized patients. Using a cut-off value of 44.18 ng/ml, PSP performs better than CRP or PCT across the considered studies. The combination of PSP with CRP further enhances its accuracy.
Long-term and acute safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio® Plus) in juvenile and adult dogs
Authors: Riggs Kari L. , Wiseman Scott
Published: May 2021

Background

The combination of milbemycin oxime (MO) and lotilaner (Credelio®Plus) is a novel systemic endectocide that provides month-long effectiveness in dogs after a single oral treatment. The safety of Credelio®Plus flavored chewable tablets was investigated in three target animal safety studies. Two studies (one in juveniles and one in adults) evaluated the long-term safety, and one study evaluated the acute safety of the product when administered orally at the upper end of the recommended dose range (0.75–1.53 mg/kg MO and 20–41 mg/kg lotilaner) and multiples of this dose.

Methods

The objectives of these studies were to determine the long-term and acute safety of MO and lotilaner flavored chewable tablets in healthy dogs. All three studies were randomized, blinded, parallel-group design studies in healthy Beagle dogs. In each of the two long-term studies, 32 dogs were randomized among four groups to untreated controls or to treated groups at target doses of 1X, 3X, or 5X. Treatment was administered on seven (adult dogs) or nine (juvenile dogs) occasions with dosing every 4 weeks. In the acute study, 48 dogs were randomized among four groups to untreated controls or to treated groups at 1X, 3X, or 6X. In all three studies, the control group was administered placebo tablets. All dogs were fed 30 to 45 min prior to treatment and the assessment of safety was based on health observations, complete physical/neurological examinations, and food consumption. For the long-term safety studies, safety assessments also included clinical pathology evaluations (hematology, clinical chemistry and urinalysis), body weight, pharmacokinetic blood collections, and macroscopic and microscopic examinations of collected tissues.

Results

MO and lotilaner did not induce any treatment-related adverse effects based on health observations, physical/neurological examinations, or food consumption in the long-term or acute studies. Additionally, in the long-term studies, MO and lotilaner did not induce any treatment-related effects on clinical pathology, body weight, and macroscopic and microscopic examinations.

Conclusions

These three studies demonstrate that Credelio®Plus has a wide safety margin when administered at monthly intervals to puppies and dogs at the high end of the commercial dose band.

Graphical Abstract
Field study to investigate the effectiveness and safety of a novel orally administered combination drug product containing milbemycin oxime and lotilaner (Credelio® Plus) for the prevention of heartworm disease (Dirofilaria immitis) in client-owned dogs in the USA
Authors: Young Lisa M. , Wiseman Scott , Crawley Elizabeth , Wallace Kim , Snyder Daniel E.
Published: May 2021

Background

Dirofilaria immitis,a globally distributed filarial parasite of dogs, is known to cause serious or fatal cardiopulmonary disease. Client-owned dogs were enrolled in a clinical field study in the USA to evaluate the clinical effectiveness and field safety of an orally administered combination investigational product (IP) containing milbemycin oxime and lotilaner (Credelio®Plus) as compared to a control product (CP) for the prevention of heartworm disease when administered monthly for 11 consecutive months.

Methods

In this 11-month field study, 319 dogs ≥ 8 weeks old confirmed to be heartworm-negative were enrolled from eight geographically distinct US veterinary clinics, including sites in the southern USA and Mississippi River Valley. The dogs were treated with either the IP combination product at 0.75–1.53 mg/kg milbemycin oxime and 20–41.5 mg/kg lotilaner (n = 159) or the CP (Sentinel®Flavor Tabs®; milbemycin oxime/lufenuron) at the label-recommended dose rate (n = 158.) On day 330, effectiveness was evaluated in each dog using antigen and microfilarial (modified Knott’s) testing to assess the establishment of any patent adult heartworm infections.

Results

All dogs treated with the IP combination product and the CP tested negative (100% prevention) for heartworm infection on day 330. The IP combination product tablets containing milbemycin oxime and lotilaner were well tolerated based on the safety assessments in all treated dogs.

Conclusions

This multi-site clinical study using client-owned dogs demonstrated that monthly use of flavored, chewable tablets containing a combination of milbemycin oxime and lotilaner administered orally under end use conditions is safe for dogs. None of the enrolled dogs developed heartworm infections. Eleven consecutive monthly treatments of the IP provided 100% prevention of heartworm disease caused byD. immitis.

Graphical Abstract
Denosumab alleviates intervertebral disc degeneration adjacent to lumbar fusion by inhibiting endplate osteochondral remodeling and vertebral osteoporosis in ovariectomized rats
Authors: Sun Qi , Tian Fa-Ming , Liu Fang , Fang Jia-Kang , Hu Yun-Peng , Lian Qiang-Qiang , Zhou Zhuang , Zhang Liu
Published: May 2021

Background

Although adjacent segmental intervertebral disc degeneration (ASDD) is one of the most common complications after lumbar fusion, its exact mechanism remains unclear. As an antibody to RANKL, denosumab (Dmab) effectively reduces bone resorption and stimulates bone formation, which can increase bone mineral density (BMD) and improve osteoporosis. However, it has not been confirmed whether Dmab has a reversing or retarding effect on ASDD.

Methods

Three-month-old female Sprague-Dawley rats that underwent L4–L5 posterolateral lumbar fusion (PLF) with spinous-process wire fixation 4 weeks after bilateral ovariectomy (OVX) surgery were given Dmab 4 weeks after PLF surgery (OVX+PLF+Dmab group). In addition, the following control groups were defined: Sham, OVX, PLF, and OVX+PLF (n=12 each). Next, manual palpation and X-ray were used to evaluate the state of lumbar fusion. The bone microstructure in the lumbar vertebra and endplate as well as the disc height index (DHI) of L5/6 was evaluated by microcomputed tomography (μCT). The characteristic alterations of ASDD were identified via Safranin-O green staining. Osteoclasts were detected using tartrate-resistant acid phosphatase (TRAP) staining, and the biomechanical properties of vertebrae were evaluated. Aggrecan (Agg), metalloproteinase-13 (MMP-13), and a disintegrin and metalloproteinase with thrombospondin motifs 4 (ADAMTS-4) expression in the intervertebral disc were detected by immunohistochemistry and real-time polymerase chain reaction (RT-PCR) analysis. In addition, the expression of CD24 and Sox-9 was assessed by immunohistochemistry.

Results

Manual palpation showed clear evidence of the fused segment’s immobility. Compared to the OVX+PLF group, more new bone formation was observed by X-ray examination in the OVX+PLF+Dmab group. Dmab significantly alleviated ASDD by retaining disc height index (DHI), decreasing endplate porosity, and increasing vertebral biomechanical properties and BMD. TRAP staining results showed a significantly decreased number of active osteoclasts after Dmab treatment, especially in subchondral bone and cartilaginous endplates. Moreover, the protein and mRNA expression results in discs (IVDs) showed that Dmab not only inhibited matrix degradation by decreasing MMP-13 and ADAMTS-4 but also promoted matrix synthesis by increasing Agg. Dmab maintained the number of notochord cells by increasing CD24 but reducing Sox-9.

Conclusions

These results suggest that Dmab may be a novel therapeutic target for ASDD treatment.
Microbial dynamic and growth potential of selected pathogens in Ethiopian traditional fermented beverages
Authors: Nemo Reda , Bacha Ketema
Published: May 2021

Purpose

The patterns of microbial succession and the associated physicochemical changes in the course of beverage fermentation determine the safety status of the final product against foodborne pathogens. In this study, the microbial dynamics during fermentation of three Ethiopian traditional fermented beverages (namely, borde, tej, and grawa) and the growth potential of selected foodborne pathogens in ready-to-consume beverages were assessed.

Methods

The raw materials used for lab-scale fermentation of the beverages were bought from open markets of Jimma and Anfilo towns. During fermentation, samples were drawn every 6 h (borde fermentation) and 12 h (grawa and tej fermentation). The dominant microbes of the fermentation phases were determined following standard microbiological methods. The growth potential of Escherichia coli, Salmonella typhimurium, Staphylococcus aureus, Listeria monocytogenes, and Candida albicans in the ready-to-consume beverages were assessed by microbial enumeration over defined storage period.

Result

Early fermentation period of all beverages was dominated by aerobic mesophilic bacteria, staphylococci, and Enterobacteriaceae with highest mean counts (Log CFU/ml) of 6.42 ± 0.10, 5.44 ± 0.08, and 5.40 ± 0.11, respectively. At the end of fermentation, yeast counts (Log CFU/ml) dominated in tej (9.41 ± 0.06) and grawa (7.88 ± 0.02) samples, while lactic acid bacteria dominated in borde sample (7.33 ± 0.07). During fermentation, pH dropped for borde (4.58 ± 0.03 to 4.22 ± 0.01), and grawa (4.18 ± 0.10 to 3.62 ± 0.02), but increased for tej (5.26 ± 0.01 to 5.50 ± 0.03) during the first 24 h, though it dropped later down to 3.81 ± 0.02 at 144th h. All reference pathogens were unable to reach infective dose in grawa and tej samples. However, borde sample supported their growth to infective dose within 24 h. Thus, grawa and tej beverages had the capability of inhibiting growth of pathogens while borde needs basic safety control measures during preparation and storage.

Conclusion

With further safety evaluation of the products, the production processes of the three beverages could be scaled up for commercial purposes using defined starter cultures originated from the same beverages. However, the safety status of borde calls for further evaluation for alternative shelf-life extension mechanisms including the introduction of organic preservatives from local products such as medicinal plants.
Intrabiliary and abdominal rupture of hepatic hydatid cyst leading to biliary obstruction, cholangitis, pancreatitis, peritonitis and septicemia: a case report
Authors: Aghajanzadeh Manouchehr , Ashoobi Mohammad Taghi , Hemmati Hossein , Samidoust Pirooz , Delshad Mohammad Sadegh Esmaeili , Pourahmadi Yousha
Published: May 2021

Background

Hydatid cysts are fluid-filled sacs containing immature forms of parastic tapeworms of the genus Echinococcus. The most prevalent and serious complication of hydatid disease is intrabiliary rupture, also known as cystobiliary fistulae. In this study, a sporadic case of biliary obstruction, cholangitis, and septicemia is described secondary to hydatid cyst rupture into the common bile duct and intraperitoneal cavity.

Case presentation

A 21-year-old Iranian man was admitted to the emergency ward with 5 days of serious sickness and a history of right upper quadrant abdominal pain, fatigue, fever, icterus, vomiting, and no appetite. In the physical examination, abdominal tenderness was detected in all four quadrants and in the scleral icterus. Abdominal ultrasound revealed intrahepatic and extrahepatic biliary duct dilation. Gallbladder wall thickening was normal but was very dilated, and large unilocular intact hepatic cysts were detected in segment IV and another one segment II which had detached laminated membranes and was a ruptured or complicated liver cyst.

Conclusion

Intrabiliary perforation of the liver hydatid cyst is an infrequent event but has severe consequences. Therefore, when patients complain of abdominal pain, fever, peritonitis, decreased appetite, and jaundice, a differential diagnosis of hydatid disease needs to be taken into consideration. Early diagnosis of complications and aggressive treatments, such as endoscopic retrograde cholangiopancreatography and surgery, are vital.
Opioid-free anesthesia—dexmedetomidine as adjuvant in erector spinae plane block: a case series
Authors: Coviello Antonio , Esposito Danilo , Galletta Roberta , Maresca Alfredo , Servillo Giuseppe
Published: May 2021

Background

Laparoscopic pain is related to the stretching of the peritoneum and peritoneal irritation caused by insufflation of the parietal peritoneum with carbon dioxide. In 2017, erector spinae plane block (ESPB) was described for management of postoperative pain following open and laparoscopic abdominal surgery. The use of multimodal anesthesia reduces both intraoperative and postoperative opioid use and improves analgesia. The addition of dexmedetomidine to the anesthetic mixture significantly prolongs analgesia, without clinically significant side effects.

Case Presentation

We describe a series of three Caucasian women cases that illustrate the efficacy of bilateral ESPB performed at the level of the T7 transverse process to provide intraoperative and postoperative analgesia for laparoscopic gynecological surgery.

Conclusion

Further investigation is recommended to establish the potential for ESPB with dexmedetomidine as adjuvant as an opioid-free anesthetic modality in laparoscopic gynecological surgery.
Proteus mirabilis thoracic vertebral osteomyelitis: a case report
Authors: Chiang Ming-Hsiu , Lee Mei-Hui , Liu Yung-Ching , Lee Chi-Hung
Published: May 2021

Background

Proteus mirabilis is the second most common pathogen that causes urinary tract infections after Escherichia coli. In rare cases, it is associated with vertebral osteomyelitis. The underlying mechanism of this relationship may be related to the retrograde dissemination of bacteria through the paravertebral venous plexus.

Case presentation

We report a case of an 80-year-old Taiwanese woman who had recurrent episodes of fever and chronic back pain for 1 year. All blood cultures were positive for P. mirabilis. Inflammation scans and magnetic resonance imaging revealed a previously undetected vertebral lesion between the seventh and eighth thoracic vertebra. She responded well to treatment with antibiotics, reporting considerable relief of back pain and no fever recurrence at the 4-month follow-up.

Conclusions

Chronic back pain is a common but often dismissed symptom among the older population; osteomyelitis should be considered in patients with recurrent fever or neurological symptoms. Old age, chronic renal failure, and diabetes mellitus are possible predisposing factors for osteomyelitis. Our findings suggest that long-term treatment with antibiotics is effective for osteomyelitis caused by P. mirabilis,, although surgery is required for abscess formation or serious vertebral destruction.
Residual feedback suppression with extended model-based postfilters
Authors: Gimm Marco , Bulling Philipp , Schmidt Gerhard
Published: May 2021

When designing closed-loop electro-acoustic systems, which can commonly be found in hearing aids or public address systems, the most challenging task is canceling and/or suppressing the feedback caused by the acoustic coupling of the transducers of such systems. In many applications, feedback cancelation based on adaptive filters is used for this purpose. However, due to computational complexity such a feedback canceler is often limited in the length of the filter’s impulse response. Consequently, a residual feedback, which is still audible and may lead to system instability, remains in most cases. In this work, we present enhancements for model-based postfilters based on a priori knowledge of the feedback path which can be used cooperatively with the adaptive filter-based feedback cancelation system to suppress residual feedback and improve the overall feedback reduction capability. For this, we adapted an existing reverberation model such that our model additionally considers the presence and the performance of the adaptive filter. We tested the effectiveness of our approach by means of both objective and subjective evaluations.
Correction to: Governing sustainability of bioenergy, biomaterial and bioproduct supply chains from forest and agricultural landscapes
Authors: Stupak Inge , Smith C. Tattersall , Clarke Nicholas
Published: May 2021

An amendment to this paper has been published and can be accessed via the original article.
Assessing sustainability factors of farmer seed production: a case of the Good Seed Initiative project in Tanzania
Authors: Kansiime M. K. , Bundi M. , Nicodemus J. , Ochieng J. , Marandu D. , Njau S. S. , Kessy R. F. , Williams F. , Karanja D. , Tambo J. A. , Romney D.
Published: May 2021

Background

Quality seed is at the core of the technological packages needed to increase crop production, nutrition, and rural wellbeing. However, smallholder farmers in Tanzania have limited access to affordable quality seeds, and over 90% of seed sown is saved by farmers from previous harvests, though its quality is often poor. The Good Seed Initiative (GSI) aimed to enhance access to quality African indigenous vegetable (AIV) seed in Tanzania, through the promotion of farmer seed production, using two models—contract farming and Quality Declared Seed (QDS). This study assessed post-GSI project sustainability factors and explored the prospects for replicating the approach in a wider regional context.

Methods

The study was conducted in Arusha and Dodoma, targeting locations where the GSI project was implemented. Qualitative tools employing focus group discussions (73 men, 69 women), and key informant interviews were used for data collection.

Results

Farmer seed production under both models continued to thrive, creating avenues for income diversification and contributing over 50% to household incomes. Farmer seed production contributed to increased availability of quality seed for vegetable growers, especially in central Tanzania that is less served by the formal sector. However, QDS production was challenged by a lack of access to foundation seed, inspections, and seed testing services, which are key for quality seed production.

Conclusions

Results reveal unequivocally that farmer seed production offers a potentially sustainable solution to the problem of seed supply while providing income benefits for seed producers. The market-based approach used by the project and partnerships with the formal sector, coupled with stimulation of demand through nutritional awareness campaigns, were strong contributory factors to the survival of farmer seed production. Farmer-led seed systems, especially QDS, deserve support from the government to develop a tailored and appropriate seed system that meets the ever-evolving needs of smallholder farmers. Adoption gender-inclusive approaches, particularly in contract farming is paramount to benefit women as much as men.
The association between obesity and weight loss after bariatric surgery on the vaginal microbiota
Authors: Raglan Olivia , MacIntyre David A. , Mitra Anita , Lee Yun S. , Smith Ann , Assi Nada , Nautiyal Jaya , Purkayastha Sanjay , Gunter Marc J. , Gabra Hani , Marchesi Julian R. , Bennett Phillip R. , Kyrgiou Maria
Published: May 2021

Background

Obesity and vaginal microbiome (VMB) dysbiosis are each risk factors for adverse reproductive and oncological health outcomes in women. Here, we investigated the relationship between obesity, vaginal bacterial composition, local inflammation and bariatric surgery.

Methods

Vaginal bacterial composition assessed by high-throughput sequencing of bacterial 16S rRNA genes and local cytokine levels measured using a multiplexed Magnetic Luminex Screening Assay were compared between 67 obese and 42 non-obese women. We further assessed temporal changes in the microbiota and cytokines in a subset of 27 women who underwent bariatric surgery.

Results

The bacterial component of the vaginal microbiota in obese women was characterised by a lower prevalence of aLactobacillus-dominant VMB and higher prevalence of a high diversity (Lactobacillusspp., andGardnerella- spp. depleted) VMB, compared with non-obese subjects (p<0.001). Obese women had higher relative abundance ofDialisterspecies (p<0.001),Anaerococcus vaginalis(p=0.021), andPrevotella timonensis(p=0.020) and decreased relative abundance ofLactobacillus crispatus(p=0.014). Local vaginal IL-1β, IL-4, IL-6, IL-8, IFNγ, MIP-1α and TNFα levels were all higher among obese women, however, only IL-1β and IL-8 correlated with VMB species diversity. In a subset of obese women undergoing bariatric surgery, there were no significant overall differences in VMB following surgery; however, 75% of these women remained obese at 6 months. Prior to surgery, there was no relationship between body mass index (BMI) and VMB structure; however, post-surgery women with aLactobacillus-dominant VMB had a significantly lower BMI than those with a high diversity VMB.

Conclusions

Obese women have a significantly different vaginal microbiota composition with increased levels of local inflammation compared to non-obese women. Bariatric surgery does not change the VMB; however, those with the greatest weight loss 6-month post-surgery are most likely to have aLactobacillus-dominant VMB.
Characterization of glass beads from Nanhai I shipwreck and new evidence of lead tin yellow type II in China
Authors: Tian Chenxin , Zhou Yihang , Wang Kai , Sun Jian , Cui Yong , Hu Dongbo
Published: May 2021

Glass beads excavated from Nanhai I shipwreck were investigated with scanning electron microscopy with energy dispersive spectrometer (SEM–EDS), Raman spectroscopy, multi-collector inductively coupled plasma mass spectrometry (MC-ICP-MS) and X-ray diffraction (XRD). Dating back to the Southern Song Dynasty, these beads help to study Chinese maritime trades during the twelfth–thirteenth century. The bead samples are categorized into five groups by color, i.e., yellow, orange-red, blue, dark red and light red. All beads are of K2O-PbO-SiO2 and PbO-SiO2 glass systems and in form of coil bead, which further confirms the Chinese origin of them. Lead tin yellow type II was identified in the opaque yellow coil beads, and K2SnxPb(1-x)Si3O9 crystals were found in both yellow and orange-red samples. Through the preparation of glass with the same formula as the ancient yellow beads, lead tin yellow type II was probably synthesized beforehand and added as colorant because its raw materials tend to form K2SnxPb(1-x)Si3O9 crystals in the K2O-PbO-SiO2 glass during firing. As lead tin yellow type II is an atypical colorant in China, these beads from Nanhai I shipwreck may serve as the first clear evidence of lead tin yellow type II presenting in the Chinese glass system. The lead isotope ratios of the yellow beads suggest they were produced in Fujian Province, China. The introduction of the lead tin yellow coloring technique might have a close connection to the glass making in the Southeast Asia and these beads seemed to be made specifically for overseas markets.
Flood inundation simulations based on GSMaP satellite rainfall data in Jakarta, Indonesia
Authors: Priyambodoho Bambang Adhi , Kure Shuichi , Yagi Ryuusei , Januriyadi Nurul Fajar
Published: May 2021

Jakarta is the capital of Indonesia and is considered one of the most vulnerable cities to climate-related disasters, including flooding, sea-level rise, and storm surges. Therefore, the development of a flood-forecasting system for Jakarta is crucial. However, the accurate prediction of flooding in Jakarta is challenging because of the short flood concentration time in highly urbanized basins and the shortage of rainfall data in poorly gauged areas. The aim of this study is to simulate recent flood inundation using global satellite mapping of precipitation (GSMaP) products. The GSMaP products (NRT and Gauge V7) were evaluated and compared with hourly observation data from five ground stations in the Ciliwung River Basin. In addition, a rainfall-runoff and flood inundation model was applied to the target basin. The results of the analysis showed that the GSMaP Gauge data were more accurate than the GSMaP NRT data. However, the GSMaP Gauge cannot be used to provide real-time rainfall data and is, therefore, inadequate for real-time flood forecasting. We conclude that the GSMaP Gauge is suitable for replicating past flood events, but it is challenging to use the GSMaP NRT for real-time flood forecasting in Jakarta.
Low dose hCG supplementation in a Gn-RH-agonist trigger protocol is associated with worse pregnancy outcomes: a retrospective cohort study
Authors: Shapiro Maren , Romanski Phillip , Thomas Ann , Lanes Andrea , Yanushpolsky Elena
Published: May 2021

Background

A number of studies have looked at dual triggers with hCG and GnRH agonist (GnRHa) in varying doses, but the question remains: what is the optimal dose of hCG to minimize ovarian hyperstimulation syndrome (OHSS) and still offer adequate pregnancy rates? The purpose of this study was to compare pregnancy and OHSS rates following dual trigger for oocyte maturation with GnRHa and a low-dose hCG versus hCG alone. A secondary objective was the assess pregnancy outcomes in subsequent frozen cycles for the same population.

Methods

A total of 963 women < 41 years old, with a BMI 18–40 kg/m2 and an AMH > 2 ng/mL who underwent fresh autologous in vitro fertilization (IVF) with GnRH antagonist protocol at a University-based fertility center were included in this retrospective cohort study. Those who received a low dose dual trigger with hCG (1000u) and GnRHa (2 mg) were compared to those who received hCG alone (10,000u hCG/250-500 μg Ovidrel). Differences in implantation rates, pregnancy, live birth, and OHSS were investigated.

Results

The dual trigger group was younger (mean 33.6 vs 34.1 years), had a higher AMH (6.3 vs 4.9 ng/mL,) more oocytes retrieved (18.1 vs 14.9) and a higher fertilized oocyte rate (80% vs 77%) compared with the hCG only group. Yet, the dual trigger group had a lower probability of clinical pregnancy (gestational sac, 43.4% vs 52.8%) and live birth (33.4% vs 45.8%), all of which were statistically significant. There were 3 cases of OHSS, all in the hCG-only trigger group. In subsequent frozen cycles, pregnancy rates were comparable between the two groups.

Conclusions

The dual trigger group had a better prognosis based on age and AMH levels and had better stimulation outcomes, but significantly worse pregnancy outcomes, suggesting the low dose hCG (1000u) in the dual trigger may not have provided adequate luteal support, compared to an hCG-only trigger (10,000u hCG/250-500 μg Ovidrel). Interestingly, the pregnancy rates were comparable in subsequent frozen cycles, further supporting the hypothesis that the issue lies in inadequate luteal phase support, rather than embryo quality. Based on these findings, our program has changed the protocol to 1500u of hCG in a dual trigger.
Evidence-based prediction and prevention of cardiovascular morbidity in adults treated for cancer
Authors: Altena Renske , Hubbert Laila , Kiani Narsis A. , Wengström Yvonne , Bergh Jonas , Hedayati Elham
Published: May 2021

Background

Cancer treatment-related morbidity relevantly compromises health status in cancer survivors, and efforts to optimise health-related outcomes in this population are vital to maximising healthy survivorship. A pre-treatment assessment – and possibly preventive management strategies – of cancer patients at increased risk for cardiovascular disease (CVD) seems a rational approach in this regard. Definitive evidence for such strategies is largely lacking, thereby impeding the formulation of firm recommendations.

Results

The current scoping review aims to summarise and grade the evidence regarding strategies for prediction and prevention of CVD in adults in relation to oncological treatments. We conducted a scoping literature search for different strategies for primary prevention, such as medical and lifestyle interventions, as well as the use of predictive risk scores. We identified studies with moderate to good strength and up to now limited evidence to recommend primary preventive strategies in unselected patients treated with potentially cardiotoxic oncologic therapies.

Conclusion

Efforts to minimize the CVD burden in cancer survivors are needed to accomplish healthy survivorship. This can be done by means of robust models predictive for CVD events or application of interventions during or after oncological treatments. Up to now there is insufficient evidence to implement preventive strategies in an unselected group of patients treated with potential cardiotoxic oncological treatments. We conclude that randomised controlled trials are needed that evaluate medical and lifestyle interventions in groups at increased risk for complications, in order to be able to influence chronic illness risks, such as cardiovascular complications, for cancer survivors.
3D inversion of large-scale frequency-domain airborne electromagnetic data using unstructured local mesh
Authors: Zhang Bo , Yin Changchun , Liu Yunhe , Ren Xiuyan , Baranwal Vikas C. , Xiong Bin
Published: May 2021

Airborne electromagnetic (AEM) methods have been more and more widely used in mineral exploration, environmental and engineering studies, and ground water investigation. However, compared with ground-based electromagnetic (EM) methods, such as magnetotelluric or controlled-source EM, AEM methods generally produce large amounts of data, which leads to very costly 3D EM inversions. We have developed a new 3D AEM inversion scheme based on the finite-element method and unstructured tetrahedral local meshes. This is different from the traditional local mesh method in that the traditional method uses regular cuboids for 3D AEM inversions, whereas our scheme uses irregular tetrahedral meshes that can easily accommodate the topography and complex underground structure. Moreover, because we create our local mesh by extracting from part of the global model mesh, the relationship between the local and global meshes is straightforward, so we can easily create a projection of the Jacobian matrix between global and local meshes and rapidly construct the global Jacobian matrix for 3D EM inversions. After formulating the boundary value problem based on the finite-element method, we verify the accuracy of our modeling algorithm by checking against the semianalytical solution for a homogeneous half-space model, and we test our inversion algorithm by running inversions on synthetic and survey data collected over Vesterålen, Norway. The numerical experiments demonstrate that our method can model the AEM responses at high accuracy and recover the subsurface main resistivity structures from synthetic and field data.
Angle-domain common-image gathers from plane-wave least-squares reverse time migration
Authors: Li Chuang , Gao Zhaoqi , Gao Jinghuai , Li Feipeng , Yang Tao
Published: May 2021

Angle-domain common-image gathers (ADCIGs) that can be used for migration velocity analysis and amplitude-versus-angle analysis are important for seismic exploration. However, because of the limited acquisition geometry and seismic frequency band, ADCIGs extracted by reverse time migration (RTM) suffer from illumination gaps, migration artifacts, and low resolution. We have developed a reflection angle-domain pseudoextended plane-wave least-squares RTM method for obtaining high-quality ADCIGs. We build the mapping relations between the ADCIGs and the plane-wave sections using an angle-domain pseudoextended Born modeling operator and an adjoint operator, based on which we formulate the extraction of ADCIGs as an inverse problem. The inverse problem is iteratively solved by a preconditioned stochastic conjugate-gradient method, allowing for reduction in computational cost by migrating only a subset instead of the whole data set and improving the image quality thanks to preconditioners. Numerical tests on synthetic and field data verify that our method can compensate for illumination gaps, suppress migration artifacts, and improve resolution of the ADCIGs and the stacked images. Therefore, compared to RTM, our method provides a more reliable input for migration velocity analysis and amplitude-versus-angle analysis. Moreover, it also provides much better stacked images for seismic interpretation.
Reflection angle/azimuth-dependent least-squares reverse time migration
Authors: Duveneck Eric , Kiehn Michael , Chandran Anu , Kühnel Thomas
Published: May 2021

Seismic images under complex overburdens such as salt are strongly affected by illumination variations due to overburden velocity variations and imperfect acquisition geometries, making it difficult to obtain reliable image amplitudes. Least-squares reverse time migration (LSRTM) addresses these issues by formulating full wave-equation imaging as a linear inverse problem and solving for a reflectivity model that explains the recorded seismic data. Because subsurface reflection coefficients depend on the incident angle, and possibly on the azimuth, quantitative interpretation under complex overburdens requires LSRTM with output in terms of image gathers, e.g., as a function of the reflection angle or angle and azimuth. We have developed a reflection angle- or angle/azimuth-dependent LSRTM method aimed at obtaining physically meaningful image amplitudes interpretable in terms of angle- or angle/azimuth-dependent reflection coefficients. The method is formulated as a linear inverse problem solved iteratively with the conjugate gradient method. It requires an adjoint pair of linear operators for reflection angle/azimuth-dependent migration and demigration based on full wave-equation propagation. We implement these operators in an efficient way by using a mapping approach between migrated shot gathers and subsurface reflection angle/azimuth gathers. To accelerate convergence of the iterative inversion, we apply image-domain preconditioning operators computed from a single de-remigration step. An angle continuity constraint and a structural dip constraint, implemented via shaping regularization, are used to stabilize the solution in the presence of limited illumination and to control the effects of coherent noise. We examine the method on a synthetic data example and on a wide-azimuth streamer data set from the Gulf of Mexico, where we find that angle/azimuth-dependent LSRTM can achieve significant uplift in subsalt image quality, with overburden- and acquisition-related illumination variation effects on angle/azimuth-dependent image amplitudes largely removed.
Pure mode P- and S-wave phase velocity equations in elastic orthorhombic media
Authors: Stovas Alexey , Roganov Yuriy , Roganov Vyacheslav
Published: May 2021

In an elastic model with orthorhombic (ORT) symmetry, there are nine independent stiffness coefficients that control the propagation of all intrinsically coupled wave modes. For practical applications in P-wave modeling and inversion, it is important to derive the approximate solutions that support propagation of P-waves only and depend on fewer independent parameters. Due to the increasing interest in S-wave propagation in anisotropic media, we also derive an approximate equation that supports propagation of S-waves only. However, the reduction in the number of independent parameters for the S-wave equation is not possible. We derive pure P- and S-wave equations in an elastic ORT model and find that the accuracy is sufficient for practical applications.
Clinic-based Procedures for Headache
Authors: Robbins Matthew S.
Published: May 2021

PURPOSE OF REVIEW

Headache disorders are common and disabling, and many therapies that are effective and safe are procedural.

RECENT FINDINGS

After pivotal clinical trials, onabotulinumtoxinA has become an established preventive therapy for chronic migraine; it is better tolerated than many other treatments and may be useful for other headache disorders. Peripheral nerve blocks, especially greater occipital nerve blocks, have amassed evidence from randomized trials in the acute and short-term preventive treatment of migraine and cluster headache. Trigger point injections and sphenopalatine ganglion blocks have recent trials suggesting efficacy and safety in properly selected patients. Medical education initiatives are needed to train neurologists in these procedures to help manage the large population of patients with headache disorders who need them.

Evidence exists for the efficacy and safety of procedural therapies to be incorporated into neurology practice for the management of patients with migraine, cluster headache, and other headache disorders.
Other Primary Headache Disorders
Authors: Smith Jonathan H.
Published: May 2021

PURPOSE

This article provides an overview of a diverse group of primary headache disorders that are categorized in the International Classification of Headache Disorders, 3rd Edition (ICHD-3), as “other primary headache disorders.” This article provides clinicians with a distilled understanding of the diagnoses and their epidemiology, pathophysiology, and management.

RECENT FINDINGS

Cough-induced headache requires neuroimaging to exclude posterior fossa pathology and recently has been reported as a common symptom in patients with CSF-venous fistula. Clinical overlap is observed between patients with primary exercise headache and primary headache associated with sexual activity. Patients with recurrent thunderclap headache associated with sexual activity should be presumed to have reversible cerebral vasoconstriction syndrome until proven otherwise. De novo external-pressure headache is a common sequela among health care workers using personal protective equipment during the COVID-19 pandemic. New daily persistent headache is an important mimicker of chronic migraine or chronic tension-type headache and is distinguished by a daily-from-onset progression of persistent headache; a treatment-refractory course is often observed, and early involvement of a multidisciplinary team, including a psychotherapist, is advised.

Patients with primary headache disorders that are classified as “other primary headache disorders” have presentations with unique diagnostic and management considerations. The disorders are highly recognizable, and an appreciation of the diagnoses will aid clinicians in providing safe and effective care for patients presenting with headache.