bluuebunny/crossref_metadata_2025 huggingface dataset:
CONSTRUCTIONS WITH THE PREPOSITION PO IN THE NOVELS THE WOMAN FROM SARAJEVO (GOSPOĐICA) AND THE DAMNED YARD (PROKLETA AVLIJA) BY IVO ANDRIĆ
Authors: Milašin Goran B.
Published: September 2023

This paper presents the analysis results of syntactic and semantic features of constructions with the preposition po in The Woman from Sarajevo (Gospođica, 1945) and The Damned Yard (Prokleta avlija, 1954) by Ivo Andrić. The main goal of the research was to determine the meanings and functions of these constructions in the novels that form the corpus of the research, but also to try to expand and supplement, on the basis of selected examples, the previous syntactic and semantic analyses of the preposition po in our older and also more recent grammars and linguistic articles. By using both the theoretical framework of cognitive semantics and the theoretical foundations of more traditional approaches to the meaning of prepositions, 298 constructions (213 from The Woman from Sarajevo and 85 from The Damned Yard) were analysed, and it was concluded that the language of Andrić’s works, at least when it comes to constructions with the preposition po, is not different from the contemporary Serbian language. Namely, it was observed that there are more locative than accusative constructions with the preposition po, and that the most frequent are the spatial locative and the base/criterion locative. At the end of the paper, we pointed out the non-prepositional function of the word po.
SERBIAN ENGLISH THROUGH THE LENS OF THE ELF RESEARCH PARADIGM
Authors: Tošić Tamara P.
Published: September 2023

Linguists around the world have been researching international English for a long time, forming three paradigms of thought and research – English as an International Language (EIL), World English (WE) and English as a Lingua Franca (ELF). The aim of this paper is to present a review of the research conducted so far regarding English in Serbia and, thus, to offer insight into the inner workings of Serbian English, all in the light of ELF research. Bearing in mind that research within the ELF paradigm framework is not carried out often in Serbia, all the studies presented in this paper view the Serbian English variety as learners’ language. The elimination of contrastive studies was taken as the basic criterion for literature selection, which made it possible to compare the Serbian linguists’ studies with the ELF paradigm framework. Studies within the scope of phonetics/phonology and pragmatics were found. As regards to phonetics and phonology, papers of only two authors fit in with the established criterion. The findings of their studies confirm that Serbian English speakers have acquired the phonetic features necessary for international communication, i.e. the ELF phonetic core. Nonetheless, it was not possible to compare Serbian English pragmatic studies with ELF research – ELF studies involve spoken corpora, while Serbian English studies encompass questionnaires and interviews. Therefore, there is much to be discovered about the Serbian variety of English. Conducting further research into Serbian English within the ELF paradigm would allow comparison with ELF standards and unveil those linguistic elements which students in Serbia need to acquire in order to participate in international communication more efficiently.
THE SIGNIFICANCE OF SERBIAN ORTHODOX PRIESTS AND MONKS IN THE 19THAND 20TH -CENTURY SERBIAN LITERATURE
Authors: Ђорић Соња С.
Published: September 2023

Приказ
FOUNDATIONS OF METHODOLOGY OF SERBIAN AS A FOREIGN LANGUAGE
Authors: Кубурић Мацура Мијана Ч.
Published: September 2023

Приказ
Development of water resources protection planning and environmental design in urban water conservancy landscape based on ecological concept
Authors: Huang Hua
Published: September 2023

With the development of society, water resources are gradually scarce and water pollution is becoming increasingly serious, which would seriously restrict the development of the urban economy. In response to the current problems of water scarcity and severe water pollution, this article will study the key points of urban environmental design development based on ecological concepts. This article will also use ecological concepts to divide water function zones based on different pollution-carrying capacities in different regions, which can be mainly divided into two levels. In the experimental analysis section, the Xiongan New Area will be analyzed. This article randomly selected three regions in the Xiongan New Area and studied the utilization rate of various types of water in these regions. The pollution capacity and main water resources of each region in the functional area were planned and designed. Through experiments, it can be found that based on ecological concepts, it is beneficial to improve the pollutant-carrying capacity of each functional area and reduce the total amount of ammonia nitrogen.
The Power of Molecular Dynamics Simulations and Their Applications to
Discover Cysteine Protease Inhibitors
Authors: dos Santos Nascimento Igor José , Santana Gomes Joilly Nilce , de Oliveira Viana Jéssika , de Medeiros e Silva Yvnni Maria Sales , Barbosa Euzébio Guimarães , de Moura Ricardo Olimpio
Published: September 2023

A large family of enzymes with the function of hydrolyzing peptide bonds, called peptidases
or cysteine proteases (CPs), are divided into three categories according to the peptide chain involved.
CPs catalyze the hydrolysis of amide, ester, thiol ester, and thioester peptide bonds. They can
be divided into several groups, such as papain-like (CA), viral chymotrypsin-like CPs (CB), papainlike
endopeptidases of RNA viruses (CC), legumain-type caspases (CD), and showing active residues
of His, Glu/Asp, Gln, Cys (CE). The catalytic mechanism of CPs is the essential cysteine residue present
in the active site. These mechanisms are often studied through computational methods that provide
new information about the catalytic mechanism and identify inhibitors. The role of computational
methods during drug design and development stages is increasing. Methods in Computer-Aided Drug
Design (CADD) accelerate the discovery process, increase the chances of selecting more promising
molecules for experimental studies, and can identify critical mechanisms involved in the pathophysiology
and molecular pathways of action. Molecular dynamics (MD) simulations are essential in any
drug discovery program due to their high capacity for simulating a physiological environment capable
of unveiling significant inhibition mechanisms of new compounds against target proteins, especially
CPs. Here, a brief approach will be shown on MD simulations and how the studies were applied to
identify inhibitors or critical information against cysteine protease from several microorganisms, such
as Trypanosoma cruzi (cruzain), Trypanosoma brucei (rhodesain), Plasmodium spp. (falcipain), and
SARS-CoV-2 (Mpro). We hope the readers will gain new insights and use our study as a guide for potential
compound identifications using MD simulations.
Conducting 2D and 3D QSAR Analyses and Molecular Docking Studies of
Analogues of 2-(1-(1,3,4-thiadiazol-2-yl)piperidin-4-yl)ethan-1-ol with the
Aim of Identifying Promising Drug Candidates for Targeting Glioblastoma
Authors: Pan Meichen , Cheng Lingxue , Wang Yiguo , Lyu Chunyi , Hou Chao , Zhang Qiming
Published: September 2023

Background:

2-(1-(1,3,4-thiadiazol-2-yl)piperidin-4-yl) ethan-1-ol analogues represent novel
glutaminase 1 inhibitors. Their exemplary antineoplastic efficacy underscores their prospective utility in
glioblastoma chemotherapy.

Objectives:

This study aimed to elucidate 2D and 3D-QSAR models that authenticate the antineoplastic
efficacy of ethan-1-ol analogues and delineate optimal structural configurations conducive to new pharmaceutical
design.

Methods:

The Heuristic Method (HM) was employed for the development of a 2D-linear QSAR paradigm,
whilst the Gene Expression Programming (GEP) algorithm was employed for a 2D-nonlinear
QSAR paradigm. Concurrently, the CoMSIA methodology was deployed to scrutinize the nexus between
pharmaceutical structure and potency. An ensemble of 200 nascent anti-glioma ethan-1-ol compounds
was conceptualized, and their potency levels were prognosticated via chemical descriptors and molecular
field delineations. Pharmaceuticals epitomizing peak potency were earmarked for molecular docking
validation.

Results:

The empirical modeling exhibited pronounced superiority with the 3D paradigm, succeeded by
the GEP nonlinear paradigm and culminated with the HM linear model. The 3D paradigm was characterized
by a robust Q2 (0.533), R2 (0.921), and F-values (132.338) complemented by a minimal SEE
(0.110). The molecular descriptor MNO coupled with the hydrogen bond donor field facilitated novel
pharmaceutical conceptualizations, leading to the identification of the quintessential active molecule,
24J.138, lauded for its superlative antineoplastic attributes and docking proficiency.

Conclusion:

The orchestration of bidimensional and tridimensional paradigms, synergized by innovative
amalgamation of contour maps and molecular descriptors, provides novel insights and methodologies for
the synthesis of glioblastoma chemotherapeutic agents.
Bone Marrow Mesenchymal Stem Cell Extracellular Vesicle-derived miR-27b-
3p activates the Wnt/Β-catenin Pathway by Targeting SMAD4 and Aggravates
Hepatic Ischemia-reperfusion Injury
Authors: Li Hongnan , Lin Weidong , Li Yunlei , Zhang Jiayang , Liu Runsheng , Qu Minghai , Wang Ruihua , Kang Xiaomin , Xing Xuekun
Published: September 2023

Background:

To investigate the roles of extracellular vesicles (EVs) secreted from bone marrow
mesenchymal stem cells (BMSCs) and miR-27 (highly expressed in BMSC EVs) in hepatic ischemia‒
reperfusion injury (HIRI).

Approaches and Results:

We constructed a HIRI mouse model and pretreated it with an injection of
agomir-miR-27-3p, agomir-NC, BMSC-EVs or control normal PBS into the abdominal cavity. Compared
with the HIRI group, HIRI mice preinjected with BMSC-EVs had significantly decreased alanine aminotransferase
(ALT) and aspartate aminotransferase (AST) levels and alleviated liver necrosis (P<0.05).
However, compared with HIRI+NC mice, HIRI+miR-27b mice had significantly increased ALT and AST
levels, aggravated liver necrosis, and increased apoptosis-related protein expression (P<0.05). The proliferation
and apoptosis of AML-12 cells transfected with miR-27 were significantly higher than the proliferation
and apoptosis of AML-12 cells in the mimic NC group (P<0.01) after hypoxia induction. SMAD4
was proven to be a miR-27 target gene. Furthermore, compared to HIRI+NC mice, HIRI+miR-27 mice
displayed extremely reduced SMAD4 expression and increased levels of wnt1, β-catenin, c-Myc, and
Cyclin D1.

Conclusion:

Our findings reveal the role and mechanism of miR-27 in HIRI and provide novel insights
for the prevention and treatment of HIRI; for example, EVs derived from BMSCs transfected with antimiR-
27 might demonstrate better protection against HIRI.
Dexmedetomidine in the Treatment of Depression: An Up-to-date Narrative Review
Authors: Al-Mahrouqi Tamadhir , Al Alawi Mohammed , Freire Rafael C.
Published: September 2023

Depressive disorders (DD) are common, and their prevalence is expected to rise over the next decade. Depressive disorders are linked to significant morbidity and mortality. The clinical conundrum of depressive disorders lies in the heterogeneity of their phenomenology and etiology. Further, the currently available antidepressants have several limitations, including a delayed onset of action, limited efficacy, and an unfavorable side effect profile. In this review, Dexmedetomidine (DEX), a highly selective and potent α2-adrenergic receptor (α2-AR) agonist, is proposed as a potentially novel antidepressant with multiple mechanisms of action targeting various depression pathophysiological processes. These mechanisms include modulation of the noradrenergic system, regulation of neuroinflammation and oxidative stress, influence on the Brain-Derived Neurotrophic Factor (BDNF) levels, and modulation of neurotransmitter systems, such as glutamate. The review begins with an introduction before moving on to a discussion of DEX's pharmacological features. The pathophysiological and phenomenological targets of DD are also explored, along with the review of the existing preclinical and clinical evidence for DEX's putative anti-depressant effects. Finally, the review ends by presenting the pertinent conclusions and future directions.
A Study of the Characteristics of Regional Building Construction Process
Authors: Yoshida Satoshi
Published: September 2023

Introduction:

In recent years, as in other fields, the architectural field has become increasingly globalized and internationalized. In this context, it is likely essential for each organization worldwide to understand how to leverage their respective strengths in internationalized projects. However, aspects of the characteristics related to how architecture is built in different regions are not fully understood.

Objective:

This study aims to develop a methodology for understanding the characteristics of architectural styles in different regions. In particular, this paper will focus on the process of building architecture and develop a methodology to understand the international differences at this point.

Methodology:

This study uses the “Architecture Concept” as the methodology. This methodology focuses on the interdependence among the components of an artifact. In this manuscript, the “building process” was considered one of the objects of this methodology. Although all construction projects take place under different conditions, it is possible to understand the tendency of design information of process design with this methodology.

Results:

This study selects regions where the building industry has reached technological maturity and compares building processes. Specifically, the UK in Europe and Japan in Asia will be compared. As a result, it is understood that the architectural process in the UK is more modular than the process in Japan. This analysis reveals that it is possible to understand the process in an “architectural” way.
Hepatotoxicity
Authors: Ashif Ikbal Abu Md , Das Parikshit , Chandel Saket Singh , Verma Deepshikha , Dutta Choudhury Paromita
Published: September 2023

The largest organ in the human body is the liver which captures 2 to 3% of
the human body weight, located on the right side of the anterior quadrant in the
abdomen and below the anterior hemidiaphragm ribcage. It performs various important
functions such as digestion of food, protein production, fluid production, detoxification
of waste, etc. Liver injury known as liver trauma can be categorized into four types:
hepatocellular, autoimmune, cholestatic and infiltrative. Drug-induced liver injury can
match with any form of acute or chronic liver injury. Acute injury to the liver is mainly
due to the action of cytochrome P450, which disintegrates drugs into electrophiles or
free radicals; these reactive metabolites can covalently act on protein and unsaturated
fatty acids for induction of lipid peroxidation which leads to calcium homeostasis or
death. Toxicology of the liver is a complex concept that entails either concurrent as
well as sequential events. These events determine the pathways, severity and effects of
liver injury. Pharmacogenetics has made great progress in current years which indicates
the creation of refined algorithms that take drug, host and environmental risk variables
into account, allowing for the selection of better medicine based on accurate risk-benefit ratio calculations. In this chapter, we will discuss the anatomy, functions of the
liver, types of liver injury, risk factors, and various treatment strategies for the
treatment of liver diseases.
Hepatoprotective Role of Medicinal Plants
Authors: Bhattacharjee Bedanta , Paul Tirna , Widyowati Retno , Kumar Sahu Ram , Kaurav Monika
Published: September 2023

With its ability to self-regenerate, the liver is considered an important gland
in the human body, performing essential functions such as the production of vital
proteins, lipids, lipoproteins, glucose homeostasis as well as the production and
secretion of vitamin stores and bile acids. Therefore, any impairment of the organ can
lead to serious problems in our bodies. There are various forms of disorders associated
with an unhealthy liver, which affect the liver in different ways and can be detected by
observing various general symptoms and some specific diagnostic tests. To treat and
control these hazardous effects on our bodies, various medicines are available in the
market that are mainly derived from plants and plant products. As they have fewer side
effects, herbal medicines have attracted much attention for alleviating various liver
diseases while maintaining a healthy lifestyle. Moreover, nanobased delivery of natural
products shows higher hepatoprotective activity than crude extracts. In this chapter,
various hepatoprotective functions of medicinal plants and their nano-based drug
delivery have been highlighted.
ANALISIS KEKUATAN IMPACT DAN MODEL PERPATAHAN KOMPOSIT POLYESTER BERPENGUAT SERAT ALAM IJUK
Authors: Dantes Kadek Rihendra , Elisa Edi , Susila I Made Pasek Budi
Published: September 2023

The objective of this study is to find significant differences in impact forces between continuous, discontinuous, and woven fiber type of polyester composites with natural palm fibers and to find out the description of the microfracture structure. This study used experimental methods with independent and dependent variables. The independent variables are continuous, discontinuous, and woven fiber type. Then, the dependent variable was impact forces. Based on the results of tests, show that results from the average score at continuous fiber type = 1.082.88 J/m2, discontinuous = 794.67 J/m2 and woven = 1.427.06 J/m2. The conclusion of this study is that between various fiber orientations was a significant difference in impact forces. The type of woven fibers has a higher value compared to the type of continuous and discontinuous fibers. Discontinuous fiber type has a lower score than continuous fiber type. The fracture model of polyester composite with natural palm fibers showed the mechanism of brittle fracture (brittle) in all test specimens. However, in specimens with the type of continuous fibers and woven, the fracture conditions indicate a brush fracture mechanism.
STUDI PERANCANGAN KAPAL PUSKESMAS KELILING UNTUK MENUNJANG PELAYANAN KESEHATAN DAERAH PESISIR KABUPATEN LEMBATA
Authors: Santosa Ari Wibawa Budi , Pangaribuan Hizkia Parningotan , Sisworo Sarjito Joko
Published: September 2023

The sinking of the floating hospital ship Dr. Lie Dharmawan has hampered health services several operational areas, one of which is Lembata Regency. Health services via ships are very much needed in Lembata Regency because many coastal areas still do not get maximum health services. The purpose of this research is to design a mobile health center ship that can reach coastal residents to get decent and good health services, and it doesn't take a long time to travel to get health services. The main size is obtained through the parent design approach method. Analysis of ship resistance using the holtrop method and ship stability analysis met the IMO stability criteria. Calculation of the profile construction according to the rules of BKI Vol.II which calculates the construction of the hull, deck, bottom, and superstructure. The results of the design of the mobile health center ship are designed with facilities that comply with the standards of the Minister of Health Regulation with a length of 23.13 m LOA, 21.31 m LPP, 20.35 m LWL, 6.82 m width, 1.5 m draft, 4.4 height m, Cb 0.548, speed 12 knots and the estimated cost of building a ship is Rp. 4,032,617,052,04.
TINJAUAN PENGEMBANGAN MATERIAL BERBASIS BARIUM TITANAT, KOMPOSIT PVDF/BATIO3 DAN BATIO3/HAP UNTUK APLIKASI ELECTROSTATIC DIELECTRIC ENERGY STORAGE CAPACITOR
Authors: Adnan Septian Rahmat , Kurniawan Budhy , Soegijono Bambang
Published: September 2023

Barium titanate (BaTiO3) is ceramic material that is widely used in various applications..Electrostatic dielectric energy storage capacitor is one of the application of Barium titanate (BaTiO3) material. Composite materials based on barium titanate (BaTiO3) such as Polyvinylidene fluoride (PVDF)/BaTiO3 and BaTiO3/HAp Hydroxyapatite have been developed to improve the electrical properties of the materials. Many  research have been reported  hat barium titanate in nano phase has a maximum dielectric constant 5000 with particle size range of 30-50 nm. The addition of BaTiO3 composition as a filler to PVDF/BaTiO3 composite caused increasing of dielectric constant compared to the dielectric constant properties of the PVDF. Similar results also found on BaTiO3/HAp composite.  From this review, it was also found that the composite of these three materials is a candidate for future material to improve the electrical properties of PVDF which have been applied to electrostatic dielectric energy storage capacitor applications.
The Supernova in Galileo’s Starry Sky and Its Impact on Astronomy
Authors: De Angelis Alessandro
Published: September 2023

In 1604, the last of the supernovae seen with the naked eye in the Milky Way had a great impact on the history of astronomy and cosmology. Scientists with different conceptions of the Universe - among them Galilei and Kepler but also Arab and Chinese astronomers - competed and collaborated to explain its nature, its origin and its astrological meaning. Even today, we still observe what remains of that supernova, and we learn about stellar astrophysics.
Patient Experience of Digitalized Follow-up of Antidepressant Treatment in Psychiatric Outpatient Care: Qualitative Analysis
Authors: Hamlin Matilda , Holmén Joacim , Wentz Elisabet , Aiff Harald , Ali Lilas , Steingrimsson Steinn
Published: September 2023

Background

Nonadherence to pharmaceutical antidepressant treatment is common among patients with depression. Digitalized follow-up (ie, self-monitoring systems through mobile apps) has been suggested as an effective adjunct to conventional antidepressant treatment to increase medical adherence, improve symptoms of depression, and reduce health care resource use.

Objective

The aim of this study was to determine patients’ experience of digitalized follow-up using a mobile app as an adjunct to treatment concurrent with a new prescription, a change of antidepressant, or a dose increase.

Methods

This was a qualitative, descriptive study. Patients at 2 psychiatric outpatient clinics were recruited at the time of changing antidepressant medication. After using a mobile app (either a commercial app or a public app) for 4-6 weeks with daily registrations of active data, such as medical intake and questions concerning general mental health status, individual semistructured interviews were conducted. Recorded data were transcribed and then analyzed using content analysis.

Results

In total, 13 patients completed the study. The mean age was 35 (range 20-67) years, 8 (61.5%) were female, and all reported high digital literacy. Overall, the emerging themes indicated that the patients found the digital app to be a valuable adjunct to antidepressant treatment but with potential for improvement. Both user adherence and medical adherence were positively affected by a daily reminder and the app’s ease of use. User adherence was negatively affected by the severity of depression. The positive experience of visually presented data as graphs was a key finding, which was beneficial for self-awareness, the patient-physician relationship, and user adherence. Finally, the patients had mixed reactions to the app’s content and requested tailored content.

Conclusions

The patients identified several factors addressing both medical adherence and user adherence to a digital app when using it for digitalized follow-up concurrent with the critical time related to changes in antidepressant medication. The findings highlight the need for rigorous evidence-based empirical studies to generate sustainable research results.
The Application of online medicine in the diagnosis and treatment of pulmonary nodules in thoracic surgery (Preprint)
Authors: shen cheng , yu xiaohui , li kaidi , guo chenglin , shi qingke , Pu Qiang
Published: September 2023

UNSTRUCTURED

In recent years, with the continuous progress of medical imaging technology and the gradual popularization of low-dose computed tomography, the clinical detection rate of pulmonary nodules has significantly increased, and patients have an increasing demand for the diagnosis and treatment of pulmonary nodules. Online diagnosis and treatment services are a rapidly developing type of diagnosis and treatment model in recent years. While greatly improving clinical diagnosis and treatment efficiency, they also provide significant satisfaction to the needs of patients. At the same time, influenced by various factors, especially the increasing demand for patient diagnosis and treatment, the continuous improvement of online diagnosis and treatment functions and the continuous expansion of service scope have become research focuses. This article reviews the application and research progress of online diagnosis and treatment in patients with pulmonary nodules in thoracic surgery.
Knowledge graph of breast cancer prevention and treatment - based on artificial intelligence theory (Preprint)
Authors: Jin Shuyan , Liang Haobin , Zhang Wenxia , Li Huan
Published: September 2023

BACKGROUND

The incidence of breast cancer has remained high and continues to rise since the 21st century. Consequently, there has been a significant increase in research efforts focused on breast cancer prevention and treatment. Despite the extensive body of literature available on this subject, systematic integration is lacking. To address this issue, knowledge graphs have emerged as a valuable tool. By harnessing their powerful knowledge integration capabilities, knowledge graphs offer a comprehensive and structured approach to understanding breast cancer prevention and treatment.

OBJECTIVE

We aimed to build a knowledge graph to integrate information related to breast prevention and treatment.

METHODS

We used MESH terms to search for clinical trial literature on breast cancer prevention and treatment published on PubMed between 2018 and 2021. We downloaded triplet data from SemmedDB and matched them with the retrieved literature to obtain triplet data for the target articles. We visualized the triplet information using NetworkX for knowledge discovery.

RESULTS

Within the scope of literature research in the past five years, Malignant neoplasm appeared most frequently (42.32%). Pharmacotherapy (19.22%) was the primary treatment method, with Paclitaxel (9.83%) being the most commonly used therapeutic drug. Through the analysis of the knowledge graph, we have discovered that there exists a complex network relationship between the treatment methods, therapeutic drugs, and preventive measures for different types of breast cancer, rather than a simple linear correlation.

CONCLUSIONS

This study constructed a knowledge graph for breast cancer prevention and treatment, which enabled the integration and knowledge discovery of relevant literature in the past five years. Researchers can gain insights into treatment methods, drugs, preventive knowledge regarding adverse reactions to treatment, and the associations between different knowledge domains from the graph.
Functional and Non-Functional Requirements of Virtual Clinic Mobile Applications: A systematic review (Preprint)
Authors: Parsaei Zahra , Jangi Majid , Tahmasebian Shahram , Ehteshami Asghar
Published: September 2023

BACKGROUND

Virtual Clinic Mobile Application (VCMA) is a valuable vehicle for management and remote monitoring of patients under different medical conditions. It can reduce the burden on outpatient services and provide follow-up options for patients who do not require a physical examination. A clear understanding of the recent literature can help identify appropriate functionalities for new development and future refinement of current applications (apps).

OBJECTIVE

This review study endeavored to identify functional and non-functional requirements for VCMA.

METHODS

This study integrates requirements of VCMA published in PubMed, Scopus, ISI Web of Science, Science Direct, ProQuest and IEEE databases in English, from database inception up to April 2022 by sing the systematic search technique. 76 of 1223 articles on VCMA met the inclusion criteria. This way, their requirements were extracted and categorized by the conventional content analysis.

RESULTS

Two main themes and 8 subthemes in terms of VCMA requirements were extracted as follows: 1) Functional requirements with 3 subthemes (Demographic data documentation, Health record, General features of user interface (UI)); 2) Non-functional requirements with 5 subthemes (Usability, Accessibility, Compatibility, Efficiency, and Security).

CONCLUSIONS

The findings underscored the mHealth solutions for virtual care and the need for development of the apps regarding the extracted functional and non-functional requirements for VCMA; however, controlled trials are needed. It is recommended that transparent reporting of mHealth interventions needs to be prioritized to enable effective interpretation of the extracted data.
Using a human-centered design process to evaluate and optimize user experience of the InPACT at Home website to promote youth physical activity (Preprint)
Authors: Hasson Rebecca , Xie Michelle , Tadikamalla Dhiraj , Beemer Lexie
Published: September 2023

BACKGROUND

Web-based physical activity interventions often fail to reach anticipated impact due to insufficient utilization by the intended audiences.

OBJECTIVE

The purpose of this study was to use a human-centered design process to optimize user experience of the Interrupting Prolonged sitting with ACTivity (InPACT) at Home website to promote youth physical activity participation.

METHODS

Qualitative interviews were conducted to assess engagement and pain points with the InPACT at Home website. Interview data was used to: (1) create affinity maps to identify themes of user responses; (2) conduct a heuristic evaluation according to Nielsen’s Usability Heuristics Framework, and (3) complete a competitive analysis to identify the strengths and weaknesses of competitors who offered similar products.

RESULTS

Key themes from end-user interviews included liking the website design, finding the website difficult to navigate, and wanting additional features (e.g., library of watched videos). Website usability issues identified were lack of labeling and categorization of exercise videos; hidden necessary actions and options hindering users from decision-making, error-prone conditions, and high cognitive load of the website. Competitive analysis results revealed that YouTube received the highest usability ratings followed by the Just Dance and Presidential Youth Fitness Program websites.

CONCLUSIONS

Human-centered design approaches are useful for bringing end-users and developers together to optimize user experience to achieve public health impact. Future research is needed to examine the effectiveness of the InPACT at Home website redesign to attract new users and retain current users, with the end goal of increasing youth physical activity engagement.
Using Large Language Models to Support Content Analysis: A Case Study of ChatGPT for Adverse Event Detection (Preprint)
Authors: Leas Eric C , Ayers John W , Desai Nimit , Dredze Mark , Hogarth Michael , Smith Davey M
Published: September 2023

UNSTRUCTURED

This study explores the potential of using large language models to assist content analysis by conducting a case study to identify adverse events (AEs) in social media posts. The case study compares ChatGPT’s performance with human annotators’ in detecting AEs associated with delta-8-tetrahydrocannabinol, a cannabis-derived product. Using the identical instructions given to human annotators, ChatGPT closely approximated human results, with a high degree of agreement noted: 94.4% (9436/10,000) for any AE detection (Fleiss κ=0.95) and 99.3% (9931/10,000) for serious AEs (κ=0.96). These findings suggest that ChatGPT has the potential to replicate human annotation accurately and efficiently. The study recognizes possible limitations, including concerns about the generalizability due to ChatGPT’s training data, and prompts further research with different models, data sources, and content analysis tasks. The study highlights the promise of large language models for enhancing the efficiency of biomedical research.
"Combining Effectiveness, Reach, and Cost of a Scalable, Digitally Delivered Weight Loss Program Delivered Through Rural Primary Care: A Hybrid Type-III Effectiveness-Dissemination Trial (Preprint)
Authors: Porter Gwenndolyn , Schwab Robert , Hill Jennie , Dzewaltowski David , Estabrooks Paul
Published: September 2023

BACKGROUND

To address the public health crisis of obesity, healthcare recommendations include referring patients to evidence-based programming. In rural areas where resources are scant, how best to identify and engage patients in weight management programming has yet to be determined.

OBJECTIVE

The purpose of this Hybrid Type-III effectiveness-dissemination trial was to report outcomes of different physician referral strategies for improving reach (i.e., number, proportion, and representativeness of participants), retention, and effectiveness of an evidence-based, digitally delivered, 12-month weight loss program in a rural region. Program implementation costs were also examined as a secondary purpose based on cost per participant and cost per participant achieving a 3% or 5% weight loss.

METHODS

Five primary care physicians were randomly assigned to a sequence of four referral strategies: point of care (POC) with active telephone follow-up (ATF); POC, no ATF; population health registry-derived letter with ATF; and letter, no ATF. Proportions of eligible participants that were referred, screened, enrolled, and engaged with the intervention were tracked for each strategy. Eligible and enrolled patients received a Bluetooth-enabled home scale, which provided data to document intervention effectiveness. Implementation costs were based on cost per participant and cost per participant achieving 3% or 5% weight loss.

RESULTS

Of a potential 991 referrals, 573 were made by the physicians over 16 weeks. Ninety-eight patients (60% female; 94% Caucasian—representative of the region) enrolled in the program. Letter referrals reached a significantly higher proportion of patients than POC (100% vs 17%) and yielded more participants (12% vs 8%, p<.05). Patients receiving ATF were significantly more likely to be screened (47% vs 7%; p<.05) and enroll (15% vs 7%, p<.05) compared to those without ATF. Total recruitment costs were $6,192; cost per enrolled patient was highest for letter with ATF ($89) but was similar for the other referral conditions (range $43-$50). Retention and weight loss did not significantly differ among referral strategies. Mean weight loss was 6.9±10.5lbs. with 42/98 and 29/98 of participants losing 3% and 5% or more of their initial body weight, respectively. Intervention implementation costs were $29,500.

CONCLUSIONS

Population health management approaches with active follow-up may not be cost-efficient for clinical settings. Digital weight-loss programs, when delivered in rural settings without a large population to benefit from scalability, may be as costly as intensive, in-person programs.

CLINICALTRIAL

ClinicalTrials.gov NCT03690557; 01/10/2018. http://clinicaltrials.gov/ct2/show/NCT03690557
Research on the Impact of Human-Computer Interaction Design on Employees’ Creativity and Innovation Ability in Work Scenarios
Authors: Zhang Xiang
Published: September 2023

The importance of human-computer interaction design in modern work environments is gradually being recognized. More and more companies are realizing that excellent human-computer interaction design can enhance employees’ creativity and innovation ability. This article will discuss this topic and explore the impact of human-computer interaction design in work scenarios on employees’ creativity and innovation ability.
Entrepreneurship in the Development of an Agile Enterprise
Authors: Raheel Ur Rehman Raheel Ur Rehman
Published: September 2023

With the escalating significance of adaptability within modern organizations, it becomes crucial to explore the means of comprehending the distinct traits exhibited by agile enterprises. Consequently, the objective of this research paper revolves around pinpointing the manifestations of entrepreneurial behavior within an agile enterprise, along with the strategic consequences of fostering agility. This study draws insights from literature in both entrepreneurship and strategic management, in conjunction with a detailed case study. The research article initiates by delving into the contextual landscape of entrepreneurship, subsequently transitioning to an exploration of the attributes inherent to agile enterprises. The outcomes gleaned from this research notably underscore the defining features of an agile enterprise operating within the contemporary business milieu. The findings distinctly underscore that qualities like entrepreneurial resourcefulness and strategic leadership significantly amplify an organization's capacity to effectively contend in an increasingly competitive and dynamic business sphere.
СЕТИ 5G: ЭВОЛЮЦИЯ К ОТКРЫТЫМ ОПТОВОЛОКОННЫМ ОПТИЧЕСКИМ ТРАНСПОРТНЫМ СЕТЯМ ЧАСТЬ 1. ПОЛНОСТЬЮ ИЛИ ЧАСТИЧНО ДЕЗАГРЕГИРОВАННЫЕ ОТКРЫТЫЕ ОПТИЧЕСКИЕ ТРАНСПОРТНЫЕ РЕШЕНИЯ
Authors: Коган С.С.
Published: September 2023

При развертывании сетей мобильной связи 5G поверх существующей или вновь создаваемой оптической транспортной инфраструктуры операторы сетей и провайдеры телекоммуникационных услуг заинтересованы во внедрении открытых решений, позволяющих применять на одной транспортной сети аппаратные платформы (АП) и программное обеспечение/операционные системы (ПО/ОС) разных производителей.
Этот интерес стимулируется также внедрением на сети 5G новых, облачных,
технологий с широким использованием центров хранения и обработки данных. Для открытых оптических транспортных решений рассматриваются варианты вертикальной (разделение АП и ПО/ОС) и горизонтальной (функциональная декомпозиция узлов сети) дезагрегации. В цикле статей представлены полностью или частично дезагрегированные варианты решений (часть 1), дан обзор работ по стандартизации решений (часть 2)
для открытых оптических транспортных сетей.
Algoritmos y condicionamiento por debajo del nivel consciente: un análisis crítico de la propuesta de Ley de Inteligencia Artificial de la Unión Europea
Authors: Beltran de Heredia Ruiz Ignasi
Published: September 2023

El artículo analiza un precepto de la Ley de Inteligencia Artificial en desarrollo por la Unión Europea, que prohíbe el uso de IA para influir en el comportamiento humano subconscientemente. A través de una perspectiva neurocientífica, el estudio cuestiona las propuestas actuales, argumentando que permiten intrusiones significativas que amenazan la libertad e identidad individual. Por ello, el artículo aboga por una prohibición total de tales prácticas, sin excepciones.
RESTORATION OF METAL MOLDS FOR CENTRIFUGAL CASTING OF PIPE FROM HIGH-STRENGTH IRON BY ARC WELDING
Authors: Slinko D. B. , Chavdarov A. V.
Published: September 2023

Currently, metal molds for casting cast-iron pipes operate under severe temperature and deformation conditions, as a result of which they fail due to wear of their inner surface and the formation of cracks and a mesh of heat in the same place. (Research purpose) The research purpose is studying the possibility of defect-free restorative surfacing of the inner surface of metal molds without preheating in the environment of protective gases. (Materials and methods) All work on the development of the metalform surfacing technology was carried out on samples cut from the original metalforms. The method of arc surfacing in the environment of protective gases was taken as a basis. Various welding wires and protective media were tested for surfacing. Assessment of the surfacing quality for the presence of pores and cracks before and after mechanical treatment was carried out visually, followed by determination of the chemical composition and hardness of the deposited layer. (Results and discussion) Surfacing was carried out on the inner surfaces of the samples without preheating them. Various wires were tested for surfacing: Sv-18XGS, Sv-18XM and Np-30XGSA based on obtaining a composition close to the composition of the base metal in the deposited layer. As a result, Sv-18XMA welding wire with a diameter of 2.0 millimeters was chosen for the restorative surfacing, and a welding mixture was used as a protective medium, ensuring satisfactory formation of the deposited layer without pores and cracks with minimal splashing in the selected modes. Studies were carried out to determine the hardness and chemical composition of the deposited layer and the base metal of metal forms. (Conclusions) Proposed a technology for reducing the surfacing of the inner surface of metal molds without preheating. A comparative analysis of the hardness and chemical composition of the deposited layer and the base metal of the metal forms showed a comparable level of hardness and alloying elements in them, which will ensure the necessary wear and heat resistance of the restored metal forms
Analysis of Energy Losses of a Gas Digester During Feed Preparation
Authors: Shuvalov A. M. , Mashkov A. N. , Tikhomirov D. A.
Published: September 2023

The results of a test to assess the energy efficiency of a gas digester with proportional regulation of gas flow, which depends on the total energy loss and is estimated by the efficiency coefficient, which is set by the ratio of the useful component of energy to total energy, including losses, are presented. (Research purpose) The research purpose is conducting experimental studies and to performing an analysis of energy losses, determining the energy parameters of a digester with proportional power control when using a thermoelectric generator. (Materials and methods) It was shown that the main indicator of the efficiency of a gas–using digester is the specific energy consumption per unit of prepared feed, as well as the effici­ency coefficient. We considered two options for determining the efficiency: calculated and experimental. (Results and discussion) The components of heat losses were given using various coefficients that vary in a wide range, which affects the accuracy of the calculation. Using experimental studies, the total gas consumption for heating the contents of the cooking container to boiling and the gas consumption for compensating heat losses and for maintaining a quiet boil were calculated, the useful component of energy for heating the product to boiling was estimated. (Conclusions) It was revealed that the total heat loss is 18.1 percent of the total energy consumption. Based on experimental data, the total gas consumption and the useful efficiency of the boiler was determined, which is equal to 84 percent. It was stated that when the cooking tank is fully loaded, the specific heat consumption is 0.017 kilowatt-hour per kilogram less than when the boiler is loaded by 20 percent.
Review of Methods for Reducing Power Losses in Electric Grids Containing Renewable Energy Sources
Authors: Bolshev V. E. , Vinogradov A. V.
Published: September 2023

In recent decades, there has been an increase in the use of renewable energy sources, which serve as the basis for the concept of distributed generation, that is, facilities that produce electricity at the location of consumers. The large-scale introduction of distributed generation affects the reliability and stability of electric power systems, including by reducing power losses in them by reducing the current in the lines. Taking into account the forecasts of many experts on the growth of distributed energy resources, the issue of studying methods for reducing electrical energy losses in distribution grids containing renewable energy sources is relevant. (Research purpose) The research purpose is determining methods for reducing electricity losses in electric grids containing renewable energy sources. (Materials and methods) Presented an information search, including an overview of Internet sources and sources of scientific literature devoted to methods of reducing electricity losses in electric grids. (Results and discussion) They used Yandex and Google search engines, Scopus, Web of Science and Google Scholar scientific databases, Cyberlenink electronic libraries as sources of information, eLIBRARY.ru , Elsevier, Springer, IEEE Xplore. It was shown that the literary analysis included 59 sources most suitable for the research topic, of which 8 sources of information are given in Russian, 51 in English. In the course of the information search, we determined methods for reducing electricity losses both in traditional electric grids and in electric grids containing renewable energy sources. (Conclusions) It was found out that the considered methods inherent in traditional power supply grids are also relevant for networks with renewable energy sources. It was revealed that the use of renewable energy sources in itself also allows to significantly reduce electricity losses in electric grids due to distributed generation
Automated Study of Electrophysical Properties of Polymeric and Composite Materials
Authors: Filippenko N. G. , Livshits A. V. , Earzaliev E. F.
Published: September 2023

The use of secondary resources and composites in modern polymer materials would make it possible to reduce the cost and change the physical and mechanical properties of the packaging material. The use of composites to impart new properties to polymers complicates the implementation of technologies for the production of products from them, which prevents the improvement of product quality. This is due to the lack of an accumulated database and methods of predictive determination of the obtained properties of composite materials and polymers produced with the use of secondary raw materials. (Research purpose) The research purpose is testing the methodology of automated determination of electrophysical parameters of polymer and composite thermoplastic materials. (Materials and methods) A resonant method of monitoring the electrophysical parameters necessary for an energy-efficient method of high-frequency electrothermal heating of polymers has been substantiated. We selected and modified with the installation of an automated monitoring and data collection system cumeter with a working chamber from a standard cell, retrofitted with a heating system and thermal insulation. (Results and discussion) The results of the use of an automated process of control and determination of electrophysical parameters of polymer and composite materials based on polypropylene, polyethylene with a composite of titanium dioxide were presented. The method of establishing analytical dependencies for calculating the correction coefficient when calculating the effect of thermal insulation material (dielectric cardboard) and air gap in the working capacitor on the even electrophysical parameters of the polymer and composite under study was shown. (Conclusions) The possibility of conducting automated studies to determine the dielectric properties of polymer and composite materials using the developed automated control system for the process of control, transmission, processing, visualization and storage of information about the dielectric properties of ε, ε», tgδ polymer and composite materials was substantiated. The heating temperature ranges of polymer and composite materials PP H030 GP/3 TS and 1060PE were identified in automatic mode in order to organize the most energy-efficient operating modes of high-frequency electrical equipment.