bluuebunny/crossref_metadata_2025 huggingface dataset:
Engaged genomic science produces better and fairer outcomes: an engagement framework for engaging and involving participants, patients and publics in genomics research and healthcare implementation
Authors: Murtagh Madeleine J. , Machirori Mavis , Gaff Clara L. , Blell Mwenza T. , de Vries Jantina , Doerr Megan , Dove Edward S. , Duncanson Audrey , Hastings Ward Jillian , Hendricks-Sturrup Rachele , Ho Calvin W. L. , Johns Amber , Joly Yann , Kato Kazuto , Katsui Keiko , Kumuthini Judit , Maleady-Crowe Fiona , Middleton Anna , Milne Richard , Minion Joel T. , Matshaba Mogomotsi , Mulrine Stephanie , Patch Christine , Ryan Rosalyn , Viney William
Published: November 2021

Genomic science is increasingly central to the provision of health care. Producing and applying robust genomics knowledge is a complex endeavour in which no single individual, profession, discipline or community holds all the answers.  Engagement and involvement of diverse stakeholders can support alignment of societal and scientific interests, understandings and perspectives and promises better science and fairer outcomes. In this context we argue for F.A.I.R.E.R. data and data use that is Findable, Accessible, Interoperable, Reproducible, Equitable and Responsible. Yet there is a paucity of international guidance on how to engage publics, patients and participants in genomics. To support meaningful and effective engagement and involvement we developed an Engagement Framework for involving and engaging participants, patients and publics in genomics research and health implementation.

The Engagement Framework is intended to support all those working in genomics research, medicine, and healthcare to deliberatively consider approaches to participant, patient and public engagement and involvement in their work. Through a series of questions, the Engagement Framework prompts new ways of thinking about the aims and purposes of engagement, and support reflection on the strengths, limitations, likely outcomes and impacts of choosing different approaches to engagement. To guide genomics activities, we describe four themes and associated questions for deliberative reflection: (i) fairness; (ii) context; (iii) heterogeneity, and (iv) recognising tensions and conflict.

The four key components in the Engagement provide a framework to assist those involved in genomics to reflect on decisions they make for their initiatives, including the strategies selected, the participant, patient and public stakeholders engaged, and the anticipated goals. The Engagement Framework is one step in an actively evolving process of building genomics research and implementation cultures which foster responsible leadership and are attentive to objectives which increase equality, diversity and inclusion in participation and outcomes.
ИМИТАЦИОННОЕ МОДЕЛИРОВАНИЕ ПРОЦЕССОВ МИГРАЦИИ НАСЕЛЕНИЯ В УСЛОВИЯХ РЫНОЧНОЙ ЭКОНОМИКИ
Authors: Gajkova Luybov V.
Published: November 2021

Рассматривается использование имитационного моделирования миграционных процессов населения, как одного из методов регулирования численности населения в условиях рыночной экономики.

Цель исследования: построение имитационной модели для определения оптимального коэффициента миграции с целью поддержания соответствующего уровня жизнедеятельности трудоспособного населения в условиях рыночной экономики.

Методы и инструменты: использован диалектический метод как общий научный метод познания; приемы и инструменты системного, сравнительного анализа и обобщений; методы и инструменты имитационного моделирования.

Результаты: описан подход к исследованию миграционных процессов на базе агентного имитационного моделирования как основы аналитической обработки полученных данных.

Область применения результатов: руководители компаний при решении вопросов определения оптимального коэффициента миграции как одной из составляющих элемента рыночной инфраструктуры в условиях цифровизации экономики.
MATHEMATICAL MODEL OF A LOGISTICS PROBLEM WITH A VARIABLE RATE
Authors: Agapova Elena G. , Popova Tatyana M.
Published: November 2021

Logistics as a science and as an area of practical knowledge has recently aroused increasing interest, since its activities are multifaceted. Logistics includes the management of transport, warehousing, inventory, human resources, the organization of information systems, commercial activities and much more. At the same time, there is a novelty of the approach in logistics - the organic interconnection, the integration of the above areas into a single management of material flows. Transport logistics refers to the main sections of the logistics of the movement of resources. Transport logistics allows you to solve many different problems of varying complexity and scale on a scientific basis.
The article deals with a mathematical model of a logistics problem with variable transportation tariffs. Numerical solutions of the mathematical model by a symmetric algorithm, based on the averaging of variable tariffs, are given. The ways of transportation cost reduction are considered.
Automation of information flows accompanying cargo flows is one of the most essential technical components of logistics. The use of methods of logistics opens up new reserves for creation of competitive advantage of this or that firm on the basis of maximum satisfaction of clients’ demands.
Purpose. Finding the minimum path by the symmetric algorithm method; investigate the efficiency of the warehouse location.
Methodology in article use methods of solving the transportation problem, elements of graph theory, elements of the theory of fuzzy sets.
Results. A study was conducted on the efficiency of the location of the warehouse, the method of symmetric algorithm was found the minimum path; estimated the cost of the input measures.
Practical implications it is expedient to apply the received results in transportation management, resource flow management (warehouses).
THE DEVELOPMENT OF AN ALGORITHM FOR ANALYSIS OF PARAMETERS IN A SATELLITE COMMUNICATION SYSTEM
Authors: Melnikova Tomara V. , Preobrazhenskiy Andrey P. , Preobrazhenskiy Yuriy P.
Published: November 2021

Satellite communication systems are characterized by a large number of parameters. This determines the need for the selection of appropriate analysis methods in order to ensure effective operation. Among the features under consideration, we single out those that are grouped into certain subsets. It is shown how the corresponding criterion of optimality can be formed in satellite systems, it is demonstrated how it will be taken into account when creating an algorithm. A random variable is generated upon completion of subsetting. It is required to obtain an optimal set of factors. They are obtained from the condition of the maximum value of the expression, which is the sum of the pairwise correlation coefficients. The subsets of indicators that are interrelated are indicated. Then we apply the methodology associated with the construction of “decision trees” in order to form a model of differential analysis. The decision tree allows you to define the classes of characteristics. The number of such classes can be more than two. Linear decision functions are selected in the decision tree in a sequential manner. They will be linked to matching criteria.
Podróż do kresu mapy. Destrukcja kartografii jako dekonstrukcja – perspektywa pragmatyczna
Authors: Piotrowski Igor
Published: November 2021

Artykuł dotyczy funkcjonowania map i ich wyobrażeń w warunkach wojennych na przykładzie polskiego materiału dotyczącego II wojny światowej. Punktem wyjścia jest relacja Mirona Biało- szewskiego zawarta w opowiadaniu Rajza dotycząca ucieczki jego rodziny we wrześniu 1939 roku w stronę granicy wschodniej. Opowiadanie wprowadza wątki, które są obecne w innych tek- stach okołowojennych i powojennych autora Pamiętnika z powstania warszawskiego, i które są interpretowane w kontekście innych źródeł (przede wszystkim literackich). Mapy używane podczas wojny miały wymiar propagandowy, dezorientowały zarówno swoich, jak i obcych użyt- kowników (czytelników). Okres wojenny oznacza ciągłe zapotrzebowanie na mapy oraz ujaw- nia deficyt przestawień kartograficznych, a jednocześnie ciągle zmieniająca się rzeczywistość obnaża ich bezużyteczność, w skrajnych przypadkach sprowadzając je do surowca wtórnego. Wojna jest stanem wyjątkowym, w którym proces dekonstrukcji kartografii zostaje przyśpie- szony. Jest to więc moment, w którym postulaty nurtu krytycznego w historii i teorii kartografii zostają spełnione, a pragmatyka dowartościowana. To użytkownik w konkretnej sytuacji dokonuje demaskacji racjonalnego umysłu stojącego za kartografią.
Mapowanie motywów mitologicznych. Zmora jako istota szkodząca ludziom i zwierzętom gospodarskim
Authors: Pieńczak Agnieszka , Povetkina Polina
Published: November 2021

Celem artykułu jest ukazanie zróżnicowania kulturowego sposobów szkodzenia ludziom i/lub zwierzętom przez istotę mitologiczną, zwaną w Polsce najczęściej zmorą czy morą, w możliwie szerokim aspekcie czasowym i przestrzennym. W tym celu przydatne stały się materiały ludoznawcze i etnograficzne pochodzące z XIX wieku (głównie drugiej połowy) oraz pierwszych trzech dekad XX stulecia. Analizę zawartości literatury ograniczono do podstawowych czaso- pism i prac zwartych, które zaprezentowano w formie obszernych aneksów i trzech map etnogeograficznych. Zestawiono je z niepublikowanymi wynikami badań Polskiego Atlasu Etnograficznego dotyczącymi demonologii ludowej, w tym omawianej postaci mitologicznej szkodzącej ludziom i/lub zwierzętom. Opracowanie na mapach dawniejszych materiałów ludoznawczych i etnograficznych wraz z późniejszymi danymi atlasowymi pozwoliło nie tylko na wytyczenie zasięgu występowania w Polsce przekonań o tym, że zmora najczęściej dręczy ludzi, rzadziej zwierzęta domowe, ale też ukazanie przemian ich granic w czasie i przestrzeni. Mapowanie pozwala również na porównanie obecnych i dawnych obszarów, na których stwierdzono obecność odrębnych motywów mitologicznych.
Communicating God’s war. Accounts of holy war in Polish medieval narrative sources
Authors: Von Güttner-Sporzynski Darius
Published: November 2021

The authors of Polish medieval narrative accounts from and about Poland communicated episodes of Christian holy war and proto-crusades in a distinct and consistent way from the early twelfth century. In this article I will argue that the anonymous author of the Gesta principum Polonorum presented the Polish conquest of Pomerania as a holy war, and that a hundred years later, the learned Vincentius Bishop of Cracow in his Chronica Polonorum depicted three military campaigns against the Prussian pagans and apostates as crusading expeditions. I will also argue that the first Polish historian Jan Długosz, deliberately celebrated and highlighted these earlier accounts to his contemporary fifteenth century readership, using these histories to position Poland’s rulers as having a longstanding and consistent commitment to crusading, at a time when participation in crusades was a central concern of Poland’s ruling elites. This article will conclude that each of these written works was a commissioned text and part of a deliberate strategy by the rulers of Poland to communicate their engagement in Christian holy wars at the periphery of Christian Europe.
Erwiderung auf die Rezension von Piotr Gotowko über das Buch: Christofer Herrmann. Der Hochmeisterpalast auf der Marienburg. Konzeption, Bau und Nutzung der modernsten europäischen Fürstenresidenz um 1400
Authors: Herrmann Christofer
Published: November 2021

Erwiderung auf die Rezension von Piotr Gotowko über das Buch: Christofer Herrmann. Der Hochmeisterpalast auf der Marienburg. Konzeption, Bau und Nutzung der modernsten europäischen Fürstenresidenz um 1400. Petersberg: Michael Imhof Verlag, 2019, veröffentlicht in Ordines Militares Colloquia Torunensia Historica 25 (2020): 435–442.
Patriotyczne karty pocztowe z kolekcji ks. Stanisława Roehlego
Authors: Nieszporek Agnieszka
Published: November 2021

W artykule przeanalizowałam dwadzieścia dwie karty pocztowe o tematyce patriotycznej z kolekcji ks. Stanisława Roehlego. Źródła pochodzą z I poł. XX wieku i dotyczą w większości czasów zaborów. Zaprezentowano na nich wielość motywów i symboli ukazanych na kartach pocztowych: wizerunki Polonii, odwołania do historii – rycerzy, powstańców, bohaterów narodowych, ważnych bitew, motywów heraldycznych, symbolu Orła Białego, ludowości czy twórców kultury polskiej. Na ich przykładzie ukazano, jak ważną funkcję pełniły w społeczeństwie polskim: odwoływały się do sfery emocjonalnej, uczyły postaw moralnych, budziły ducha narodu, utrwalały świadomość narodową, konsolidowały różne warstwy społeczne, uczyły historii, budziły nadzieję i otuchę, pokazywały piękno ojczyny oraz stwarzały możliwości prezentacji tych treści warstwom mniej wykształconym. W czasach po odzyskaniu niepodległości, stawały się wyrazem wdzięczności za ojczyznę oraz troski o jej przyszłe losy.
Polish History In the Sermons of Bl. Fr. Jerzy Popieluszko’s
Authors: Szczecina Grzegorz Kamil
Published: November 2021

There was a number of recurring themes appearing in Blessed Jerzy Popieluszko’s (1982–1984) sermons. Patriotism, however, is a chief one. The martyr priest wanted to form the national awareness, promote the love for the Country and present the Polish past. The historical examples include the 19th-century uprisings, the world wars, the Battle of Warsaw, the restoration of independence in 1918, The Warsaw Uprising, the anti-Soviet guerrilla warfare and the working-class strikes spanning till 1980. The preacher did not include the historical references just to present facts, although this would have made sense in the context of the Communist propaganda. The main purpose was to show to the fellow Poles the meaning of self-sacrifice and suffering as a price which had to be paid in the struggle for national liberty over centuries. Moreover, the preacher intended to keep up the spirits of the nation terrorised by the martial state and to give hope stemming from the religious and patriotic values. In Blessed Jerzy Popieluszko’s mind they would eventually pave the way towards Polish freedom and independence.
Estimating Lost Sales for Substitutable Products with Uncertain On-Shelf Availability
Authors: Steeneck Daniel , Eng-Larsson Fredrik , Jauffred Francisco
Published: November 2021

Problem definition: We address the problem of how to estimate lost sales for substitutable products when there is no reliable on-shelf availability (OSA) information. Academic/practical relevance: We develop a novel approach to estimating lost sales using only sales data, a market share estimate, and an estimate of overall availability. We use the method to illustrate the negative consequences of using potentially inaccurate inventory records as indicators of availability. Methodology: We suggest a partially hidden Markov model of OSA to generate probabilistic choice sets and incorporate these probabilistic choice sets into the estimation of a multinomial logit demand model using a nested expectation-maximization algorithm. We highlight the importance of considering inventory reliability problems first through simulation and then by applying the procedure to a data set from a major U.S. retailer. Results: The simulations show that the method converges in seconds and produces estimates with similar or lower bias than state-of-the-art benchmarks. For the product category under consideration at the retailer, our procedure finds lost sales of around 3.0% compared with 0.2% when relying on the inventory record as an indicator of availability. Managerial implications: The method efficiently computes estimates that can be used to improve inventory management and guide managers on how to use their scarce resources to improve stocking execution. The research also shows that ignoring inventory record inaccuracies when estimating lost sales can produce substantially inaccurate estimates, which leads to incorrect parameters in supply chain planning.
Developing Primary Students’ Understanding of Mathematics through Mathematization: A Case of Teaching the Multiplication of Two Natural Numbers
Authors: Thi Nguyen , Phu Nguyen
Published: November 2021

Numeracy is one of the essential competencies that the objectives of teaching math to primary students should be towards. However, many research findings show that the problem of “innumeracy” frequently exists at primary schools. That means children still do not feel at home in the world of numbers and operations. Therefore, the paper aims to apply the realistic mathematics education (RME) approach to tackling the problem of innumeracy, in the case of teaching the multiplication of two natural numbers to primary students. We conducted a pedagogical experiment with 46 grade 2 students who have not studied the multiplication yet. The pedagogical experiment lasted in six lessons, included seven activities and nine worksheets which are designed according to fundamental principles of RME by researchers. This is mainly a qualitative study. Based on data obtained from classroom observations and students’ response on worksheets, under the perspective of RME, the article pointed out how mathematization processes took place throughout students' activities, their attitudes towards math learning, and their learning outcomes. The study results found that students were more interested in math learning and understood the concepts of multiplication of two natural numbers.
Peripheral Nerve Stimulator-Guided Regional Anaesthesia for Modified Radical Mastectomy in High-Risk Patients – A Case Series
Authors: Sethi Shilpi , Sethi Manish
Published: November 2021

Thoracic paravertebral block (TPVB) is an effective and time-tested regional anesthesia (RA) technique of anesthesia/analgesia for breast surgeries. It can be performed by landmark guided, peripheral nerve stimulator (PNS) guided or ultrasound-guided techniques. We used PNS guided TPVB for carcinoma breast surgery in fifteen high-risk patients where general anesthesia was not feasible. All patients had undergone surgeries under standalone RA techniques and without any block-related complications. We describe 15 cases in which PNS guided TPVB and supraclavicular brachial plexus block were performed to conduct modified radical mastectomy under RA and monitored anesthesia care.
Keywords: Paravertebral block, Supraclavicular brachial plexus block, Carcinoma breast, Postoperative analgesia.
Pocketbook on Regional Anesthesia Techniques: Each Line Matters
Authors: Karim Habib Md Reazaul , Nair Abhijit S.
Published: November 2021

Dear editor,
There has been an ardent interest noticed in the last decade amongst members of anaesthesia fraternity to learn the art of regional anaesthesia (RA). Use of ultrasound (US) has revolutionised the practice of RA all over the world. Every month there is a description of either a new block or a modification of an existing block. Although this keeps RA enthusiasts occupied with various experiments and thus reinventing his/her skills, it also adds to the confusion. The US workshops are useful to Anaesthesiologist’s who have access to the US.
Practitioners in the periphery especially freelancers and Anaesthesiologists working in small, resource-limited setups are the ones who should be skillful in landmark/ loss of resistance (LOR) and peripheral nerve stimulation (PNS) guided RA techniques. Anatomy, landmarks, and techniques are equally important [1]. RA that is usually taught in medical colleges and teaching institutes to postgraduate students are spinal/epidural anaesthesia, few upper limb blocks (supraclavicular/axillary), and few lower limb blocks (femoral/sciatic/popliteal). The students do not get adequate confidence during training and later either have to attend workshops or become faculty in some teaching institutes to master RA skills.
The relationship between nerve and needle tip at the moment of injection is critical. Nerve localisation techniques have evolved over the years [2]. There are workshops conducted all over the globe that teach US and PNS-guided RA techniques. However, it has been observed that the participants are mostly not actively practicing hands-on during such sessions. An illustrated pocketbook showing images, key points, and relevant landmarks of the regularly performed RA techniques were therefore long-awaited. Finally, three RA enthusiasts from India: Dr. Santosh Kumar Sharma, Dr. Tuhin Mistry, and Dr. Kala Eshwaran have compiled a book in which they have described LOR-based and PNS-guided techniques using illustrated and sel
Multiwavelength photo-magnetic imaging algorithm improved for direct chromophore concentration recovery using spectral constraints
Authors: Nouizi Farouk , Algarawi Maha , Erkol Hakan , Luk Alex , Gulsen Gultekin
Published: November 2021

Multiwavelength photo-magnetic imaging (PMI) is a novel combination of
diffuse optics and magnetic resonance imaging, to the best of our
knowledge, that yields tissue chromophore concentration maps with high
resolution and quantitative accuracy. Here, we present the first
experimental results, to the best of our knowledge, obtained using a
spectrally constrained PMI image reconstruction method, where
chromophore concentration maps are directly recovered, unlike the
conventional two-step approach that requires an intermediate step of
reconstructing wavelength-dependent absorption coefficient maps. The
imposition of the prior spectral information into the PMI inverse
problem improves the reconstructed image quality and allows recovery
of highly quantitative concentration maps, which are crucial for
effective cancer detection and characterization. The obtained results
demonstrate the higher performance of the direct reconstruction
method. Indeed, the reconstructed concentration maps are not only of
higher quality but also obtained approximately 2 times faster than the
conventional method.
How to predict relapse in leukemia using time series data: A comparative in silico study
Authors: Hoffmann Helene , Baldow Christoph , Zerjatke Thomas , Gottschalk Andrea , Wagner Sebastian , Karg Elena , Niehaus Sebastian , Roeder Ingo , Glauche Ingmar , Scherf Nico
Published: November 2021

Risk stratification and treatment decisions for leukemia patients are regularly based on clinical markers determined at diagnosis, while measurements on system dynamics are often neglected. However, there is increasing evidence that linking quantitative time-course information to disease outcomes can improve the predictions for patient-specific treatment responses. We designed a synthetic experiment simulating response kinetics of 5,000 patients to compare different computational methods with respect to their ability to accurately predict relapse for chronic and acute myeloid leukemia treatment. Technically, we used clinical reference data to first fit a model and then generate de novo model simulations of individual patients’ time courses for which we can systematically tune data quality (i.e. measurement error) and quantity (i.e. number of measurements). Based hereon, we compared the prediction accuracy of three different computational methods, namely mechanistic models, generalized linear models, and deep neural networks that have been fitted to the reference data. Reaching prediction accuracies between 60 and close to 100%, our results indicate that data quality has a higher impact on prediction accuracy than the specific choice of the particular method. We further show that adapted treatment and measurement schemes can considerably improve the prediction accuracy by 10 to 20%. Our proof-of-principle study highlights how computational methods and optimized data acquisition strategies can improve risk assessment and treatment of leukemia patients.
Mesenchymal stromal cell-derived extracellular vesicles reduce lung inflammation and damage in nonclinical acute lung injury: Implications for COVID-19
Authors: Cloer Caryn , Roudsari Laila , Rochelle Lauren , Petrie Timothy , Welch Michaela , Charest Joseph , Tan Kelly , Fugang Li , Petersen Thomas , Ilagan Roger , Hogan Sarah
Published: November 2021

Mesenchymal stem cell derived extracellular vesicles (MSC-EVs) are bioactive particles that evoke beneficial responses in recipient cells. We identified a role for MSC-EV in immune modulation and cellular salvage in a model of SARS-CoV-2 induced acute lung injury (ALI) using pulmonary epithelial cells and exposure to cytokines or the SARS-CoV-2 receptor binding domain (RBD). Whereas RBD or cytokine exposure caused a pro-inflammatory cellular environment and injurious signaling, impairing alveolar-capillary barrier function, and inducing cell death, MSC-EVs reduced inflammation and reestablished target cell health. Importantly, MSC-EV treatment increased active ACE2 surface protein compared to RBD injury, identifying a previously unknown role for MSC-EV treatment in COVID-19 signaling and pathogenesis. The beneficial effect of MSC-EV treatment was confirmed in an LPS-induced rat model of ALI wherein MSC-EVs reduced pro-inflammatory cytokine secretion and respiratory dysfunction associated with disease. MSC-EV administration was dose-responsive, demonstrating a large effective dose range for clinical translation. These data provide direct evidence of an MSC-EV-mediated improvement in ALI and contribute new insights into the therapeutic potential of MSC-EVs in COVID-19 or similar pathologies of respiratory distress.
Gene Expression of Antioxidant Enzymes in the Resected Intestine in Crohn’s Disease
Authors: Sotona Otakar , Peterová Eva , Örhalmi Július , Dušek Tomáš , Mrkvicová Alena , Knoblochová Veronika , Lochman Petr , Malý Ondřej , Páral Jiří , Bureš Jan
Published: November 2021

Introduction: The inflammatory process in Crohn’s disease (CD) is closely associated with the formation of reactive oxygen species. Antioxidant enzymes can play an important role in the outcome of CD and may influence postoperative recurrence in these patients. The aim of our study was to evaluate gene expression of intracellular antioxidant enzymes in surgically resected intestinal specimens of patients with CD, both in macroscopically normal and in inflamed tissue. Methods: A total of 28 patients referred for elective bowel resection were enrolled in the study. Full-thickness small intestinal specimens were investigated. Gene expression of antioxidant enzymes – superoxide dismutase (SOD), glutathione peroxidase (GPX), glutathione reductase (GSR) – was evaluated both in macroscopically normal and inflamed samples. Results: There were significantly lower levels of SOD1 mRNA (p = 0.007) and GSR mRNA (p = 0.027) in inflamed tissue compared to macroscopically normal areas. No significant differences were found between affected and non-affected intestinal segments in mRNA for SOD2, SOD3 and GPX. Conclusions: Our pilot data clearly showed that the gene expression of major antioxidant enzymes is not a uniform mechanism in the pathogenesis of Crohn’s disease. Topically decreased gene expression of SOD1 and GSR might facilitate the segmental tissue injury caused by reactive oxygen species.
The Use of Doppler Ultrasound to Diagnose Deep Vein Thrombosis of the Lower Limbs
Authors: Hussein Nagla , Khalid Mohamed
Published: November 2021

In most cases of pulmonary embolism, death occurs as a result of deep vein thrombosis (DVT) of the lower extremities. Therefore, to avoid DVT complications and sequel, DVT must be diagnosed as early as possible and this can be achieved via B-mode and colour Doppler imaging. The present paper seeks to investigate the suitability of the imaging method of ultrasound for lower extremity DVT diagnosis and to explore the outcomes of the use of this method in DVT cases. To this end, the paper undertakes a retrospective descriptive study of 50 cases of ultrasound-based diagnosis of DVT at King Khalid Hospital in the period between January 2019 and August 2020. Half of the cases were subjected to compression, colour, and duplex ultrasound, 14 cases were subjected to compression and duplex ultrasound, and 11 cases were subjected to compression and colour Doppler. The mean age across all cases was 46.2±19.9 years. The majority of cases (56%) were in the age range 22-41 years old (n=28), while 28% of cases were in the age range 42-61 years old (n=14), 6% of cases were in the age range 62-81 years old (n=3), and 10% of cases were in the age range 82-102 years old (n=5). Regarding sex, females accounted for 60% of cases, while males accounted for the rest of 40%. Furthermore, in 90% of cases (n=45), just one lower extremity was affected, whereas in 10% of cases (n=5), both lower extremities were affected. Regarding thrombus location, it was found mostly in the area above the knee, particularly the popliteal vein (34%), common femoral vein (18%), and superficial femoral vein (20%). Moreover, 2% of cases presented thrombus in the calf vein. In 26% of cases, multiple veins were affected. DVT was acute in 76% of cases (n=38) and chronic in 24% of cases (n=12). It is concluded that symptomatic and at-risk cases benefit from the use of ultrasound for DVT diagnosis. The suitability of this method stems from its lack of invasiveness and capability to assess thrombus location, magnitude, and stage.
Los espacios domésticos para la lectura y el atesoramiento de libros: una visión sobre la Zaragoza del barroco
Authors: Postiigo Vidal Juan
Published: November 2021

The intention of this paper is to introduce the reader to the issue of space where one used to read and collect books within the residential structures in seventeenth-century Zaragoza. For this purpose, the author analyzes the inventories of movables, the essential source for studies into aspects of daily life and material culture.
Többdimenziós kulturális értékteremtés a Veszprém-Balaton2023 Európa Kulturális Fővárosa projekt tükrében
Authors: Lőrincz Katalin , Raffay–Danyi Ágnes , Cerquetti Mara
Published: November 2021

A TANULMÁNY CÉLJA

A tanulmány célja a kulturális értékteremtés jellemzőinek bemutatása a Veszprém-Balaton2023 Európa Kulturális Fővárosa program (továbbiakban Veszprém-Balaton2023 EKF program) tükrében. A vizsgálatot a többdimenziós értékteremtés öt pillére alapján végeztük Veszprémben és a Balaton térségben működő kulturális és turisztikai szervezetek körében. Jelen kutatás a következő kérdésekre fókuszál: 1) hogyan működik közre jelenleg a kulturális szektor a város és a Balaton térség fenntartható fejlesztésében; 2) melyek a veszprémi kulturális szakpolitika és menedzsment legfőbb gyengeségei, fejlesztendő területei; 3) melyek azok az EKF-től várt hatások, melyek hosszú távon ösztönözhetik a helyiek kultúrához való kapcsolódását, illetve kulturális fogyasztását? A tanulmány a kulturális és turisztikai szektorban megjelenő közösségi részvétel és a hálózatosítás szerepére fókuszál, amely segítségével megvalósulhat a térség hosszú távú kulturális, társadalmi és gazdasági fejlődése.

ALKALMAZOTT MÓDSZERTAN

Az értékteremtéssel kapcsolatos nemzetközi és hazai szakirodalom áttekintése alapján megalkottuk a kutatás elméleti kereteit: a többdimenziós értékteremtés öt pillérének vizsgálatát végeztük az esettanulmány (Veszprém-Balaton2023 EKF program) megközelítés mentén. A kutatást 2019 szeptemberében és októberében bonyolítottuk le Veszprém és a Balaton térségben strukturált interjúk, valamint stratégiai dokumentumok elemzésének segítségével. Az interjúalanyok kiválasztása során törekedtünk a kultúra minél szélesebb területének lefedésére és a turizmus kiterjedt ernyőfogalma alatt (láthatatlan, nem konvencionális, mindennapi térpályáktól eltérő mobilitás) tárgyalt folyamatok (Michalkó – Ilyés 2020) vizsgálatára. Ebből adódóan a strukturált interjúk során kilenc kulturális intézmény (kulturális központ, könyvtár, színház, múzeum, művészeti galéria), továbbá a veszprémi és a térségi turisztikai desztináció menedzsment szervezetek képviselőinek véleményét elemeztük.

LEGFONTOSABB EREDMÉNYEK

A kutatási eredmények a részvétel, a bevonódás és a hálózatosodás különböző szintjeit mutatják be. Olyan releváns innovációkat javasolnak, melyek a kulturális szféra hosszú távú fenntartható fejlesztése érdekében megvalósíthatók.

GYAKORLATI JAVASLATOK

Az eredmények a kulturális alapú városfejlesztésben érdekelt, valamint a kulturális kínálatot, programokat priorizáló hazai települések számára tartalmaznak menedzsmentre vonatkozó javaslatokat. Az eredmények alapján a Veszprém-Balaton térségben a kulturális kínálat jelenlegi irányítása fejlesztésre szorul; kiemelten átgondolandó az értékteremtési mechanizmusok megújítása.  

Köszönetnyilvánítás: Jelen kutatás az Európai Unió, Magyarország és az Európai Szociális Alap társfinanszírozása által biztosított forrásból az EFOP-3.6.2-16-2017-00017 azonosítójú "Fenntartható, intelligens és befogadó regionális és városi modellek" című projekt keretében jött létre.
The spatial organisation of Soba: a medieval capital on the Blue Nile
Authors: Drzewiecki Mariusz , Ryndziewicz Robert , Ciesielska Joanna , Kurcz Maciej , Michalik Tomasz , Czyżewska-Zalewska Ewa
Published: November 2021

Recent geophysical exploration and excavations, together with new radiocarbon dates, have shed light on the spatial organisation of medieval Soba in Sudan, and can partly be connected to the oral histories of the city's demise.
Seizure Prediction in Genetic Rat Models of Absence Epilepsy: Improved Performance through Multiple-Site Cortico-Thalamic Recordings Combined with Machine Learning
Authors: Budde Björn , Maksimenko Vladimir , Sarink Kelvin , Seidenbecher Thomas , van Luijtelaar Gilles , Hahn Tim , Pape Hans-Christian , Lüttjohann Annika
Published: November 2021

Seizure prediction is the grand challenge of epileptology. However, effort was devoted to prediction of focal seizures, while generalized seizures were regarded as stochastic events. Long-lasting local field potential (LFP) recordings containing several hundred generalized spike and wave discharges (SWDs), acquired at eight locations in the cortico-thalamic system of absence epileptic rats, were iteratively analyzed in all possible combinations of either two or three recording sites, by a wavelet-based algorithm, calculating the product of the wavelet-energy signaling increases in synchronicity. Sensitivity and false alarm rate of prediction were compared between various combinations, and wavelet spectra of true and false positive predictions were fed to a random forest machine learning algorithm to further differentiate between them. Wavelet analysis of intracortical and cortico-thalamic LFP traces showed a significantly smaller number of false alarms compared with intrathalamic combinations, while predictions based on recordings in Layers IV, V, and VI of the somatosensory-cortex significantly outreached all other combinations in terms of prediction sensitivity. In 24-h out-of-sample recordings of nine Genetic Absence Epilepsy Rats from Strasbourg (GAERS), containing diurnal fluctuations of SWD occurrence, classification of true and false positives by the trained random forest further reduced the false alarm rate by 71%, although at some trade-off between false alarms and sensitivity of prediction, as reflected in relatively low F1 score values. Results provide support for the cortical-focus theory of absence epilepsy and allow the conclusion that SWDs are predictable to some degree. The latter paves the way for the development of closed-loop SWD prediction-prevention systems. Suggestions for a possible translation to human data are outlined.
An Efficient Modification of Grey Wolf Optimization Using Cuckoo Search, Levy Fly and Mantegna Algorithm for Real-Time Image Processing Applications
Authors:   Faculty of Electronics & Telecommunication Engineering, IIEST, Shibpur, Howrah-711103, Dutta Sayantan , Banerjee Ayan ,   Faculty of Electronics & Telecommunication Engineering, IIEST, Shibpur, Howrah-711103
Published: November 2021

Optimization methods, frequently used in several image and video processing algorithms for the attainment of optimal solutions, pose severe hurdle in case of real-time processing. For catering to the needs of real-time operations in a cost-effective way, dedicated hardware is inevitable. The huge computational load of any optimization method strikes down its feasibility of being realized in terms of dedicated hardware. The computational complexities of meta-heuristic optimization methods are even more than any other conventional optimization methods. So, in spite of having the capability of providing global solution by dodging local optima, meta-heuristic optimizations are avoided in real-time systems. To overcome the bottleneck, in this article, a modified GWOA (modified grey wolf optimization algorithm)is formulated by blending the advantages of CS (cuckoo search), Levy fly (LV), and MA (Mantegna algorithm). This modified GWOA is articulated to be computationally efficient and precise, so that, it can easily be realized in terms of dedicated VLSI architecture while maintaining the accuracy at a high level. The proposed method helps to diminish the cost and power requirement of high end and costly real-time imaging/ video processing systems while upholding its precision. The proposed method is tested by using MATLAB R2018b. The high-level synthesis (HLS) tool of Xilinx Vivado18.2softwareisusedtosynthesizethisMGWOA, thus establishing the viability of the proposed algorithm to be implemented on FPGA/ ASIC.
Intelligent Software-Aided Contact Tracing Framework: Towards Real-Time Model-Driven Prediction of Covid-19 Cases in Nigeria
Authors:   Department of Computer Science, Faculty of Science, University of Uyo, Uyo, Akwa Ibom State, Nigeria, N. Udo Edward , B. Isong Etebong ,   Department of Computer Science, Faculty of Physical Sciences, Akwa Ibom State University, Ikot Akpaden, Mkpat Enin, Nigeria, E. Nyoho Emmanuel ,   Department of Computer Science, Faculty of Science, University of Uyo, Uyo, Akwa Ibom State, Nigeria
Published: November 2021

As many countries around the world are trying to live with the deadly coronavirus by adhering to the safety measures put in place by their government as regulated by World Health Organization (WHO), it becomes very vital to continuously trace patients with COVID-19 symptoms for isolation, quarantine and treatment. In this work, an intelligent software-aided contact tracing for real-time model-driven prediction of COVID-19 cases is proposed utilizing COVID-19 dataset from kaggle.com. The dataset is preprocessed using One-Hot encoding and Principal Component Analysis. Isolation Forest algorithm is used to train and predict COVID-19 cases. The performance of the model is evaluated using Accuracy, Precision, Recall and F1-Score. The intelligent software-aided contact tracing framework has four layers: symptoms, modeling/prediction, cloud storage/contact routing and contact tracers. The contact tracing system is an android application that receives symptom values, predict it and automatically send the prediction result together with user’s contact and location details to the closest contact tracer via the Firebase real-time database. The closest contact tracer is determined by employing a dynamic routing algorithm (contact routing algorithm) that uses Open Shortest Path First (OSPF) protocol to compute the distance between two geographic locations (user and contact tracer) and chooses a contact tracer with shortest distance to the patient utilizing a unicast routing technique (routing a patient to a contact tracer in a one-to-one relationship). The predictive model along with the android application for software-aided contact tracing is implemented using the python, and Java programming language on Pycharm and Android Studio IDE respectively. This Framework is capable of predicting COVID-19 patients, notifying contact tracers of positive cases for proper follow-up which can subsequently curtail the spread of the virus.
Professor P. I. Shatilov in memoriam: to the 100th anniversary of the death
Authors:   Kharkiv National Medical University, Demochko H.L. , Robak I.Yu. ,   Kharkiv National Medical University
Published: November 2021

The relevance of the study is caused by the fact that the personality of P. Shatilov does not have a sufficient scientific reflection in the literature from the standpoint and with the use of methods of studying medical local lore. In particular, historical research methods are neglected, however, they can be used to study the work of P. Shatilov in Kharkiv in more detail during the epidemics that engulfed the city in 1919-1921. Today, when the whole world suffers from coronavirus infection, it is extremely important to give an example of medical struggle in emergencies, the victories of P. Shatilov not only as a physician but also as a citizen, because such examples instill responsibility to society. Task: to provide an updated biographical study of P. Shatilov for the centenary of his death, taking into account the methods of historical research, which had not previously been used in works of this kind. After all, medical personnel require a wider use of methods than previously represented biographical studies on the figure of P. Shatilov. To reproduce the biography of a scientist on a historical background, highlighting not only personal data, but also depicting the era in which the scientist lived and worked.
Informativeness of methods of radiation diagnostics in the detection of liver hemangiomas
Authors:   Azerbaijan Medical University, Najafova V.N.
Published: November 2021

The use of methods of radiation diagnostics, which, being currently non-invasive and highly effective methods in the diagnosis of secondary liver neoplasms, are of great practical importance in the absence of the specificity of data from both clinical and laboratory methods in the examination of metastatic lesions of the hepatobiliary system organs. Purpose of the study: comparative assessment of the capabilities of radiation methods in the differential diagnosis of liver hemangiomas in patients with overweight and obesity. Materials and research methods. To do this, we conducted a two-step study. The study included 22 patients with primary hepatic hemangioma without liver dystrophy and 18 patients with hemangioma and obesity. At the next stage of the study, the location and number of hemangiomas were studied in 25 patients with hemangioma, but without obesity in the liver, and in 15 people with hemangioma and obesity. The exogenousness of the liver was studied according to the results of ultrasound in patients without (34) and with fatty degeneration of the liver (27). Patients underwent the following examinations: magnetic resonance imaging (MRT), computed tomography (CT) and ultrasound (USI). Study results and discussion: The study showed that localization and hemangiomas in the liver with and without obstruction in 11 of 22 patients identified by MRI had only 1 hemangioma in the liver, which is 50% of the corresponding study group. Numerous hemangiomas were found in the liver in 3 out of 15 patients or in 20% of patients with grade II obesity. Results from MRT and KT studies indicate that patients with or without obesity in the liver are more likely to have single hemangiomas. With the help of ultrasound, it was revealed that in 31 out of 34 patients without steatosis, hyperechogenicity of the liver was observed.
FEATURES TO DISTINGUISH BETWEEN TRUSTWORTHY AND FAKE NEW
Authors:   Department of Cybernetics and Artificial Intelligence, Faculty of Electrical Engineering and Informatics, Technical University of Košice, Letná 9, 042 00 Košice, Slovak Republic, CHOVANEC Daniel , PARALIČ Ján ,   Department of Cybernetics and Artificial Intelligence, Faculty of Electrical Engineering and Informatics, Technical University of Košice, Letná 9, 042 00 Košice, Slovak Republic
Published: November 2021

This paper discusses the necessity of fake news detection and how selected features can show differences between trustworthy and fake news. To demonstrate this concept, we first identified a set of features, that we believe can distinguish between fake and trustworthy news. We used these features to analyse two real datasets and evaluated our results in various ways. We first used visual analysis by means of boxplots and evidenced the significance of differences by means of the Wilcox singed-rank test. As next, we used three different classification algorithms to train models for distinguishing between trustworthy and fake news using all important features. Finally, we used Principal Component Analysis (PCA) to visualize relations between identified features.
Developing water supply system in Szőgye
Authors: Fecser Nikolett , Lakatos István
Published: November 2021

The deteriorative processes occurring in the environment, the growth of population, the water demand of industry and agriculture, point out day after day the increasing role of water management. The economical use of drinking-water consumption as well as the cost reduction is becoming more and more important. In this research, the measure of a water supplier of Győr was examined in terms of implementing the purposes above.
lived experiences of ngā tāne Māori with hip and knee osteoarthritis Te Whatarangi
Authors: Dixon Te Whatarangi , O'Brien Daniel W. , Terry Gareth , Baldwin Jennifer N. , Ruakere Tom , Mekkelholt Toni , Larmer Peter J.
Published: November 2021

Osteoarthritis (OA) is a debilitating condition affecting an individual’s quality of life in multiple ways. However, little is known about about the experiences of täne (men) Māori living with OA in Aotearoa New Zealand. We aimed to explore the lived experiences of ngā tāne Māori with OA. This qualitative study was guided by tikanga and kaupapa Māori philosophies. Interviews were conducted in a semi-structured method, with seven tāne Māori living with OA. Key themes were identified and developed from the data through thematic analysis, and were informed by Tā Mason Durie’s Māori health frameworks, Te Whare Tapa Whā and Te Pae Māhutonga. Four themes developed from the data and were named: (1) The interface of masculine embodiment and mana, (2) Taha whānau and connection as central to ngā tāne Māori wellbeing, (3) The benefits of taha wairua (spiritual wellbeing), and (4) Te urutau kia uru ki te punaha tiaki hauora: Adapting to access the health-care system. OA places a significant burden on ngā tāne Māori and their whānau, impacting on all aspects of hauora (health). The unique lived experiences and impact on wider whānau of Māori living with OA indicates the need to consider te ao Māori (Māori world view) when developing clinical services and a Model of Care for OA.
Experiences and perceived effectiveness of carbon-fibre triplanar orthotics for people affected by polio: A qualitative descriptive study
Authors: Martin Rachelle A. , Fitzpatrick Anne C. , Levack William M. M.
Published: November 2021

A new type of carbon-fibre triplanar orthotic (CTO) was recently introduced to New Zealanders affected by polio. This study aimed to assess CTO recipients’ experiences and perceptions of these orthotics. A qualitative descriptive study based on semi-structured interviews was conducted to explore experiences of people who have had polio regarding the impact of CTOs on health and wellbeing, the process of training and adjustment, and how benefits from the CTOs were or were not achieved. Participants described substantial investments of time, energy and money needed to acquire and adapt to CTOs (Theme 1). They expected the CTOs to improve their posture, mobility, relieve pain and prevent prevent deterioration in functioning. However, frequently there was a mismatch between reality and expectations (Theme 2). Ongoing orthotic and rehabilitation support plus sustained commitment and effort by CTO recipients contributed to benefits gained from these orthotics (Theme 3). When considering purchase of a CTO, people who have had polio should be aware of the time, energy, effort and personal cost required to fully benefit from the new orthotic. They should also be aware that individual responses to orthotics, including subjective reports of success, can be highly variable.