bluuebunny/crossref_metadata_2025 huggingface dataset:
Creation and characterization of novel rat model for recessive dystrophic epidermolysis bullosa: Frameshift mutation of the Col7a1 gene leads to severe blistered phenotype
Authors: Stone William , Strege Chloe , Miller William , Geurts Aron M. , Grzybowski Michael , Riddle Megan , Lees Christopher , Eide Cindy , Keene Douglas R. , Tufa Sara F. , Seelig Davis , McGrath John , Tolar Jakub
Published: May 2024

Recessive dystrophic epidermolysis bullosa is a rare genodermatosis caused by a mutation of the Col7a1 gene. The Col7a1 gene codes for collagen type VII protein, a major component of anchoring fibrils. Mutations of the Col7a1 gene can cause aberrant collagen type VII formation, causing an associated lack or absence of anchoring fibrils. This presents clinically as chronic blistering, scarring, and fibrosis, often leading to the development of cutaneous squamous cell carcinoma. Patients also experience persistent pain and pruritus. Pain management and supportive bandaging remain the primary treatment options. The pathology of recessive dystrophic epidermolysis bullosa was first described in the 1980s, and there has since been a multitude of encouraging treatment options developed. However, in vivo research has been hindered by inadequate models of the disease. The various mouse models in existence possess longevity and surface area constraints, or do not adequately model a normal human disease state. In this paper, we describe a novel rat model of recessive dystrophic epidermolysis bullosa that offers an alternative to previous murine models. An 8-base pair deletion was induced in the Col7a1 gene of Lewis rats, which was subsequently found to cause a premature stop codon downstream. Homozygous mutants presented with a fragile and chronically blistered phenotype postnatally. Further histological analysis revealed subepidermal clefting and the absence of anchoring fibrils. The generation of this novel model offers researchers an easily maintained organism that possesses a larger surface area for experimental topical and transfused therapies to be tested, which may provide great utility in the future study of this debilitating disease.
Health-related quality of life and impact of socioeconomic status among primary and secondary school students after the third COVID-19 wave in Berlin, Germany
Authors: Kern Mascha , Glatz Toivo , Mall Marcus A. , Seybold Joachim , Kurth Tobias , Mockenhaupt Frank P. , Theuring Stefanie
Published: May 2024

In the earlier phases of the COVID-19 pandemic, studies in Germany and elsewhere found an overall reduction in health-related quality of life (HRQoL) among students. However, there is little evidence on later pandemic stages as well as socioeconomic influencing factors. We aimed to (1) describe HRQoL in a Berlin student cohort at two time points in mid-2021, and to (2) analyze the effects of household income and education. We assessed HRQoL of students from 24 randomly selected primary and secondary schools in Berlin, Germany, with the KIDSCREEN-10 index in June and September 2021. To adjust for non-response bias, inverse probability weighting was applied. The potential effects of both household income and education (lower vs. higher) were estimated in generalized linear mixed models, based on prior assumptions presented in directed acyclic graphs. Our cohort comprised 660 students aged 7–19 years. In June 2021, 11.3% [95% CI = 9.0% - 14.0%] reported low HRQoL, whereas in September 2021, this increased to 13.7% [95% CI = 11.1% - 16.5%], with adolescent girls more frequently reporting low HRQoL at both time points (20% [95% CI = 17.1% - 23.3%] and 29% [95% CI = 25.5% - 32.5%]) compared to boys and younger children. While there was no statistically significant total effect of lower household income on HRQoL, a negative effect of lower household education was statistically significant (β= -2.15, SE 0.95, 95% CI = -4.01 to -0.29,p= 0.024). In summary, students’ HRQoL in mid-2021 was better than that documented in other studies conducted at pandemic onset using KIDSCREEN-10. Female adolescents reported low HRQoL more often, and lower household education significantly reduced children’s HRQoL. Support strategies for psychosocial wellbeing should consider socioeconomically disadvantaged children as important target groups.
Developing consensus to enhance perinatal mental health through a model of integrated care: Delphi study
Authors: Ou Christine , Daly Zachary , Carter Michelle , Hall Wendy A. , Zusman Enav Z. , Russolillo Angela , Duffy Sheila , Jenkins Emily
Published: May 2024

Perinatal mental illness is an important public health issue, with one in five birthing persons experiencing clinically significant symptoms of anxiety and/or depression during pregnancy or the postpartum period. The purpose of this study was to develop a consensus-based model of integrated perinatal mental health care to enhance service delivery and improve parent and family outcomes. We conducted a three-round Delphi study using online surveys to reach consensus (≥75% agreement) on key domains and indicators of integrated perinatal mental health care. We invited modifications to indicators and domains during each round and shared a summary of results with participants following rounds one and two. Descriptive statistics were generated for quantitative data and a thematic analysis of qualitative data was undertaken. Study participants included professional experts in perinatal mental health (e.g., clinicians, researchers) (n = 36) and people with lived experience of perinatal mental illness within the past 5 years from across Canada (e.g., patients, family members) (n = 11). Consensus was reached and all nine domains of the proposed model for integrated perinatal mental health care were retained. Qualitative results informed the modification of indicators and development of an additional domain and indicators capturing the need for antiracist, culturally safe care. The development of an integrated model of perinatal mental health benefitted from diverse expertise to guide the focus of included domains and indicators. Engaging in a consensus-building process helps to create the conditions for change within health services.
How did we protect children against COVID-19 in Iran? Prevalence of COVID-19 and vaccination in the socio-economic context of COVID-19 epidemic
Authors: Vameghi Meroe , Saatchi Mohammad , Bahrami Giti , Soleimani Farin , Takaffoli Marzieh
Published: May 2024

Introduction

The COVID-19 pandemic posed significant risks to children worldwide. This study aimed to assess the COVID-19 protection status of children and explored the relationship between household socio-economic status and COVID-19 morbidity and preventive measures, including vaccination and mask-wearing, in two cities in Iran.

Method

A population-based cross-sectional study was conducted from July to October 2022 among 7 to 18-year-old children and their families in Tehran and Karaj. A total of 3,022 samples were selected using stratified multistage cluster sampling. Data were collected through interviews with children and adults, using questionnaires and was analyzed with Stata software version 14.

Results

The analysis focused on 2,878 children with a median age of 12. Over half (54%) reported that the pandemic negatively affected their family’s financial status, with 45% describing its impact on children’s needs as negative or very negative. Just under 50% of respondents consistently wore masks during the study period, and around 54% had received at least one dose of the COVID-19 vaccine. Reasons for not getting vaccinated included concerns about side effects, ineligibility for the target age group, and overcrowding at vaccination sites. The odds of not getting vaccinated were significantly lower for children aged 15–18, with boys more likely to refuse vaccination than girls.

Conclusion

The financial impact of the pandemic in Iran affected families’ ability to meet their children’s needs. Moreover, low vaccination acceptance rates increased children’s vulnerability to health problems and contributed to COVID-19 infections. Efforts should be made to increase vaccination acceptance, particularly among immigrant populations.
NF-κB1 deficiency promotes macrophage-derived adrenal tumors but decreases neurofibromas in HTLV-I LTR-Tax transgenic mice
Authors: Song Xinxin , Qu Zhaoxia
Published: May 2024

Human T-cell leukemia virus type I (HTLV-I) is an oncogenic virus whose infection can cause diverse diseases, most notably adult T-cell leukemia/lymphoma (ATL or ATLL), an aggressive and fatal malignancy of CD4 T cells. The oncogenic ability of HTLV-I is mostly attributed to the viral transcriptional transactivator Tax. Tax alone is sufficient to induce specific tumors in mice depending on the promotor used to drive Tax expression, thereby being used to understand HTLV-I tumorigenesis and model the tumor types developed in Tax transgenic mice. Tax exerts its oncogenic role predominantly by activating the cellular transcription factor NF-κB. Here, we report that genetic deletion of NF-κB1, the prototypic member of the NF-κB family, promotes adrenal medullary tumors but suppresses neurofibromas in mice with transgenic Tax driven by the HTLV-I Long Terminal Repeat (LTR) promoter. The adrenal tumors are derived from macrophages. Neoplastic macrophages also infiltrate the spleen and lymph nodes, causing splenomegaly and lymphadenopathy in mice. Nevertheless, the findings could be human relevant, because macrophages are important target cells of HTLV-I infection and serve as a virus reservoir in vivo. Moreover, the spleen, lymph nodes and adrenal glands are the most common sites of tumor cell infiltration in HTLV-I-infected patients. These data provide new mechanistic insights into the complex interaction between Tax and NF-κB, therefore improving our understanding of HTLV-I oncogenic pathogenesis. They also expand our knowledge and establish a new animal model of macrophage neoplasms and adrenal tumors.
Peripheral intravenous catheter failure, nurse staffing levels and care complexity individual factors: A retrospective multicentre cohort study
Authors: Jiménez-Martínez Emilio , Adamuz Jordi , González-Samartino Maribel , Muñoz-Carmona Maria Antonia , Hornero Ana , Martos-Martínez M. Purificacion , Membrive-Martínez Remedios , Juvé-Udina Maria-Eulàlia
Published: May 2024

Introduction

Short peripheral intravenous catheter (PIVC) failure is a common complication that is generally underdiagnosed. Some studies have evaluated the factors associated with these complications, but the impact of care complexity individual factors and nurse staffing levels on PIVC failure is still to be assessed. The aim of this study was to determine the incidence and risk factors of PIVC failure in the public hospital system of the Southern Barcelona Metropolitan Area.

Methods

A retrospective multicentre observational cohort study of hospitalised adult patients was conducted in two public hospitals in Barcelona from 1st January 2016 to 31st December 2017. All adult patients admitted to the hospitalisation ward were included until the day of discharge. Patients were classified according to presence or absence of PIVC failure. The main outcomes were nurse staffing coverage (ATIC patient classification system) and 27-care complexity individual factors. Data were obtained from electronic health records in 2022.

Results

Of the 44,661 patients with a PIVC, catheter failure was recorded in 2,624 (5.9%) patients (2,577 [5.8%] phlebitis and 55 [0.1%] extravasation). PIVC failure was more frequent in female patients (42%), admitted to medical wards, unscheduled admissions, longer catheter dwell time (median 7.3 vs 2.2 days) and those with lower levels of nurse staffing coverage (mean 60.2 vs 71.5). Multivariate logistic regression analysis revealed that the female gender, medical ward admission, catheter dwell time, haemodynamic instability, uncontrolled pain, communication disorders, a high risk of haemorrhage, mental impairments, and a lack of caregiver support were independent factors associated with PIVC failure. Moreover, higher nurse staffing were a protective factor against PIVC failure (AUC, 0.73; 95% confidence interval [CI]: 0.72–0.74).

Conclusion

About 6% of patients presented PIVC failure during hospitalisation. Several complexity factors were associated with PIVC failure and lower nurse staffing levels were identified in patients with PIVC failure. Institutions should consider that prior identification of care complexity individual factors and nurse staffing coverage could be associated with a reduced risk of PIVC failure.
Cultural food practices and sources of nutrition information among pregnant and postpartum migrant women from low- and middle-income countries residing in high income countries: A systematic review
Authors: Olajide Bolanle R. , van der Pligt Paige , McKay Fiona H.
Published: May 2024

Women in low- and middle-income countries (LMICs) may engage in a range of cultural food practices during pregnancy, including restricting or avoiding foods high in protein and iron, and foods rich in vitamins and minerals. While research has explored the cultural food practices of pregnant women in LMICs, there is less understanding of the continued cultural food practices of women who migrate to high-income countries and then become pregnant. This systematic review explores the existing research on cultural food practices and sources of nutrition information among pregnant and postpartum migrant women from LMICs, residing in high-income countries. A systematic search was conducted in April 2024 across Global Health, CINAHL, and MEDLINE, published in English, with no date restrictions. Eligible studies included those focused on pregnant and postpartum women who had migrated from LMICs to high-income countries. Studies were excluded if they comprised of non-immigrant women or did not involve LMIC participants. Screened were studies for eligibility, data were extracted, and study quality was assessed. In total, 17 studies comprising qualitative (n = 10) and quantitative (n = 7) approaches were included. In 14 studies participants adhered to cultural food practices, wherein certain nutritious foods were restricted during pregnancy or the postpartum period; three studies noted limited adherence due to support, acculturation, and access to traditional foods. Most studies (n = 10) reported traditional “hot” and “cold” food beliefs during pregnancy and postpartum, aiming to maintain humoral balance for maternal and child health and to prevent miscarriage. Nutrition advice was sought from family members, friends, relatives, healthcare providers, and media sources, with a preference for advice from family members in their home countries. There is a need for culturally appropriate nutrition education resources to guide pregnant migrants through healthy and harmful cultural food practices and overall nutrition during this crucial period. (PROSPERO Registration: CRD42023409990).
Association of tuberculosis risk with genetic polymorphisms of the immune checkpoint genes PDCD1, CTLA-4, and TIM3
Authors: Liu Chi-Wei , Wu Lawrence Shih-Hsin , Lin Chou-Jui , Wu Hsing-Chu , Liu Kuei-Chi , Lee Shih-Wei
Published: May 2024

The immune checkpoint proteins were reported to involve to host resistance to Mycobacteria tuberculosis (Mtb). Here, we evaluated 11 single nucleotide polymorphisms (SNPs) in PDCD1, CTLA4, and HAVCR2 genes between participants with and without TB infection. Genomic DNA isolated from 285 patients with TB and 270 controls without TB infection were used to perform the genotyping assay. Odds ratios were used to characterize the association of 11 SNPs with TB risk. In this study, the various genotypes of the 11 SNPs did not differ significantly in frequency between the non-TB and TB groups. When patients were stratified by sex, however, men differed significantly from women in genotype frequencies at HAVCR2 rs13170556. Odds ratios indicated that rs2227982, rs13170556, rs231775, and rs231779 were sex-specifically associated with TB risk. In addition, the combinations of rs2227982/rs13170556 GA/TC in men and the A-C-C haplotype of rs231775-rs231777-rs231779 in women were significantly associated with TB risk. Our results indicate that rs2227982 in PDCD1 and rs13170556 in HAVCR2 are associated with increased TB susceptibility in men and that the CTLA4 haplotype appears protective against TB in women.
Crosstalk between circadian clocks and pathogen niche
Authors: Borrmann Helene , Rijo-Ferreira Filipa
Published: May 2024

Circadian rhythms are intrinsic 24-hour oscillations found in nearly all life forms. They orchestrate key physiological and behavioral processes, allowing anticipation and response to daily environmental changes. These rhythms manifest across entire organisms, in various organs, and through intricate molecular feedback loops that govern cellular oscillations. Recent studies describe circadian regulation of pathogens, including parasites, bacteria, viruses, and fungi, some of which have their own circadian rhythms while others are influenced by the rhythmic environment of hosts. Pathogens target specific tissues and organs within the host to optimize their replication. Diverse cellular compositions and the interplay among various cell types create unique microenvironments in different tissues, and distinctive organs have unique circadian biology. Hence, residing pathogens are exposed to cyclic conditions, which can profoundly impact host–pathogen interactions. This review explores the influence of circadian rhythms and mammalian tissue-specific interactions on the dynamics of pathogen–host relationships. Overall, this demonstrates the intricate interplay between the body’s internal timekeeping system and its susceptibility to pathogens, which has implications for the future of infectious disease research and treatment.
The Little Mermaid, Rob Marshall (dir.) (2023), USA: Walt Disney Pictures
Authors: Ue Tom
Published: May 2024

Review of: The Little Mermaid, Rob Marshall (dir.) (2023), USA: Walt Disney Pictures
Merrily We Roll Along, directed by Maria Friedman
Authors: Chow Janine
Published: May 2024

Review of: Merrily We Roll Along, directed by Maria Friedman

Hudson Theatre, New York, USA, 18 November 2023
Doors, Floors, Street
Authors: Valença Márcio Moraes
Published: May 2024

This paper, divided in five sections, is supported by established theoretical background. The paper points to the idea of human emancipation and to the potential role of architecture in helping the development of a more just and egalitarian society. The terms and concepts that are used in this essay have something in common; although they refer to different intellectual and disciplinary contexts, they have overlapping features which are critical to the understanding of an active, participatory culture in everyday life as a necessary aspect of society. People must take charge of their own lives and of the immediate conditions of living of their surroundings. The idea of co‑creation that is presented more fully in Section 5 benefits from the discussions in previous sections about the private and public space, the right to the city, Michel de Certeau’s views on walking, and Reyner Banham’s concept of the responsive environment. Co-creation is participation in its ultimate form. The fundamental idea is to plan and build a better world and better cities collectively. To make this easier, architects should also co-create more adaptable, controllable, and responsive buildings and urban spaces. Co-creation must be fostered, using intensive participatory processes, to define certain features of what is being done or built. However, this struggles against all odds to become a common practice in public policy. The search for social justice in the city still has a long way to go. Having said this, architecture and urban design are too important to be left out; they may not change the world but may help to make it better.
Pausânias. Descrição da Grécia. Livro VI
Authors: Silva Maria de Fátima
Published: May 2024

Pausânias é o nosso único testemunho de literatura periegética e o autor de um relato precioso sobre a Grécia da época de ocupação romana (séc. II d.C.). A sua descrição é a de alguém que viajou e sintetiza o que &amp;#039;viu&amp;#039;, com um olhar que não é só o de um turista curioso, mas de um intelectual que dispõe de uma sólida formação cultural e de uma informação ampla, em resultado de uma recolha criteriosa de todo o tipo de fontes, orais e escritas. Para com Pausânias mantemos em aberto uma enorme dívida: a de ter salvado um lastro de monumentos, de aconteci­mentos históricos, de figuras e de tradições que, sem ele, se teriam em definitivo apagado da memória dos homens.
La cuestión agraria en Brasil ¿raíces históricas de la desigualdad? (1850-2016)
Authors: Gonçalves-Almeida Rafael
Published: May 2024

A través de los estudios de la antropología social relacionados con la evolución histórica de la cuestión agraria, este artículo pretende desarrollar una visión novedosa sobre los orígenes de la desigualdad socioeconómica en Brasil. País caracterizado por notables tasas agro-exportadoras, conocido, también, como uno de los mayores productores de commodities del mundo, además de ser la mayor potencia agraria del continente latinoamericano. Sin embargo, es un país donde más de la mitad de la población se encuentra actualmente en situación de vulnerabilidad alimentaria. Una situación que se ha agravado en los últimos años con la subida de los precios de las materias primas, consecuencia, en parte, de la pandemia del coronavirus y de la guerra en Ucrania. De esta manera, el presente estudio busca comprender las razones del proceso excluyente de reparto de tierras a lo largo de los siglos en Brasil, comparando los diferentes ejemplos de reformas agrarias ocurridas en el mundo contemporáneo, ya que a diferencia de la mayoría de los países industrializados, la dicha nación hasta hoy no ha llevado a cabo una política duradera y amplia de reestructuración de la división de sus tierras. Las razones de la ausencia de una reforma agraria coherente y su relación con la desigualdad social es el tema central de este artículo.
Antropología, ética y planes de formación. Propuesta de un plan formativo para una empresa de la madera en España
Authors: Pérez Conde María Luisa , Jiménez Eguizábal Alfredo
Published: May 2024

Uno de los principales desafíos de las empresas del siglo xxi para poder competir en el mercado globalizado es la formación del talento humano, factor decisivo para afrontar un mercado laboral cada vez más incierto. El artículo muestra la investigación llevada a cabo para generar un plan de formación en el ámbito empresarial de la madera, con el propósito de responder a la nueva realidad laboral, incrementando no solo la competitividad de cada puesto de trabajo, sino contribuyendo también a generar una empresa sostenible, solidaria y éticamente responsable. Los resultados del estudio demuestran la importancia de la formación, los instrumentos metodológicos que tienen las empresas para detectar las necesidades formativas y las implicaciones antropológicas que suscita el diseño de una propuesta de formación adaptada a las necesidades laborales.
A Permanência Estudantil na Universidade Brasileira: Reflexões Sobre as Políticas de Assistência Estudantil
Authors: De Lima Maria Janete
Published: May 2024

Este artigo trata de um ensaio teórico sobre políticas de assistência estudantil numa universidade brasileira em especial na Universidade Federal de Campina Grande, no campus do Centro de Formação de Professores, a influência da governamentalidade neoliberal nas diretrizes destas políticas de assistência, para tanto foi utilizado autores como Foucault, Castro, Chaui, Gallo, Veiga-Neto, Feldens e Santana entre outros. O objetivo é aproximar as reflexões sobre os programas desenvolvidos na universidade pública brasileira e suas formas de atuação, implementação, acompanhamento e revisão no tocante a assistência estudantil. O Programa Nacional de Assistência Estudantil-pnaes se desenvolve por meio dos programas: Residência Universitária e o Programa de Auxílio ao Ensino de Graduação-paeg. A metodologia é uma revisão teorica que tem como base a tese de Doutorado em Educação da autora apresentada na Universidade Federal de Sergipe no Programa de Pós graduação na qual obteve o título de Doutora com o tema das políticas de assistência estudantil.
¿Desproletarización y fin del trabajo? Dos estudios de caso sobre las nuevas formas de dominación en la clase trabajadora
Authors: Morfin Liñan Jesús Antonio , Flores Morales María de Lourdes
Published: May 2024

En este artículo proponemos la existencia de nuevas formas de dominación sobre el trabajo que se plasman en la diversidad en que se ganan la vida los sujetos antropológicos. En este sentido, discutimos con acercamientos teóricos recientes que afirman la existencia de un proceso de desproletarización que impide que estos sujetos puedan vender su fuerza de trabajo. No obstante, consideramos que dicho proceso, antes de ser eNunciado como uno de desproletarización, debe ser analizado etnográficamente y dar cuenta de sus particularidades históricas. Por ello, analizamos dos casos de estudio para dar cuenta de la proletarización que experimentan migrantes mexicanos en contextos contrastantes: unos legales y regulados por el estado en Canadá y otros como ilegales e (i)regulados por el estado en Estados Unidos.
Bleeding Risk of Cold Versus Hot Snare Polypectomy for Pedunculated Colorectal Polyps Measuring 10 mm or Less: Subgroup Analysis of a Large Randomized Controlled Trial
Authors: Tseng Cheng-Hao , Chang Li-Chun , Wu Jia-Ling , Chang Chi-Yang , Chen Chi-Yi , Chen Peng-Jen , Shun Chia-Tung , Hsu Wen-Feng , Chen Yen-Nien , Chen Chieh-Chang , Huang Tien-Yu , Tu Chia-Hung , Chen Mei-Jyh , Chou Chu-Kuang , Lee Ching-Tai , Chen Po-Yueh , Lin Jaw-Town , Wu Ming-Shiang , Chiu Han-Mo
Published: May 2024

INTRODUCTION:

Concerns regarding bleeding remain in cold snare polypectomy (CSP) for small pedunculated (0-Ip) polyps. The aim of this study was to compare the risk of CSP and hot snare polypectomy (HSP) for such lesions.

METHODS:

Data on 0-Ip colorectal polyps ≤10 mm were extracted from a large, pragmatic, randomized trial. Immediate postpolypectomy bleeding (IPPB), defined as the perioperative use of a clip for bleeding, was evaluated through polyp-level analysis. Delayed postpolypectomy bleeding (DPPB), defined as bleeding occurring within 2 weeks postoperatively, was assessed at the patient-level among patients whose polyps were all ≤10 mm, including at least one 0-Ip polyp.

RESULTS:

A total of 647 0-Ip polyps (CSP: 306; HSP: 341) were included for IPPB analysis and 386 patients (CSP: 192; HSP: 194) for DPPB analysis. CSP was associated with a higher incidence of IPPB (10.8% vs 3.2%, P < 0.001) but no adverse clinical events. The procedure time of all polypectomies was shorter for CSP than for HSP (123.0 ± 117.8 vs 166.0 ± 237.7 seconds, P = 0.003), while the procedure time of polypectomies with IPPB were similar (249.8 ± 140.2 vs 227.4 ± 125.9 seconds, P = 0.64). DPPB was observed in 3 patients (1.5%) in the HSP group, including one patient (0.5%) with severe bleeding, but not in the CSP group.

DISCUSSION:

Despite CSP being associated with more IPPB events, it could be timely treated without adverse outcomes. Notably, no delayed bleeding occurred in the CSP group. Our findings support the use of CSP for 0-Ip polyps ≤ 10 mm.
Hepatocellular Carcinoma With Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma in the Absence of Cirrhosis
Authors: Tu Betty H. , Khalyfa Ahamed , Bellizzi Andrew M. , Tanaka Tomohiro
Published: May 2024

This report describes a rare case of hepatocellular carcinoma (HCC) concurrent with chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) without traditional risk factors, such as hepatic fibrosis or chronic hepatitis. Initially presenting with hematuria, incidental imaging revealed a liver lesion, later diagnosed as moderately differentiated HCC. Notably, the patient had no history of well-established risk factors of HCC including viral hepatitis or liver cirrhosis. CLL/SLL was unexpectedly discovered in the surgical specimen during the hepatectomy. This case challenges traditional perceptions of HCC etiology, suggesting a potential link between HCC and CLL/SLL even without established risk factors.
Anti-N‐Methyl‐D Receptor Encephalitis During Long-Term Adalimumab Therapy for Crohn's Disease
Authors: MacKay Scott , Salh Baljinder
Published: May 2024

A 46-year-old woman with fistulizing Crohn's disease in clinical remission in the setting of long-term adalimumab therapy presented to hospital and was ultimately diagnosed with anti‐N‐methyl‐D (NMDA) receptor antibody-mediated autoimmune encephalitis (NMDAr-AE). Inflammatory central nervous system and antibody-mediated adverse effects have been found to be associated with anti–tumor necrosis factor agents, with 5 previous case reports noting cases of NMDAr-AE in patients on these medications. The current article reports this case, which is unique for the length of adalimumab therapy before this presentation, as well as a summary of literature regarding anti–tumor necrosis factors and NMDAr-AE.
Analisis Mengenai Hubungan Obesitas, Aktivitas Fisik, dan Stres Kerja Dengan Kejadian Hipertensi Pada Guru SMA Negeri di Kecamatan Kota Kabupaten Sumenep
Authors: Imamah Syarofatul , Prasetyowati Irma , Antika Ruli Bahyu
Published: May 2024

Hypertension is known as "The Silent Killer" and causes many deaths. Riskesdas 2018 stated that hypertension in the population aged 18 increased from 26.2% in 2013 to 36.3% in 2018. Based on data from the Sumenep Health Office, it was stated that the prevalence of hypertension has increased from 2019 to 2020. This study aims to analyze the association between obesity, physical activity, and work stress with the incidence of hypertension among high school teachers in the Sub-District of Sumenep Regency. This research was a quantitative analytic study with a cross-sectional research design. Respondents in this research were high school teachers in the Sub-District of Sumenep Regency. The sample was 59 respondents used the multistage random sampling technique with proportional random sampling and simple random sampling. This research used sphygmomanometer digital, scales, microtoice, Baecke Questionnaire, and HARS (Hamilton Anxiety and Rating Scale). The analysis used was Chi-Square test. Based on the study's result, it can be concluded that physical activity (p-value = 0.039) is associated with the incidence of hypertension in high school teachers. There was a significant association between physical activity and the incidence of hypertension in high school teachers.
HUBUNGAN ANTARA FAKTOR PENGETAHUAN, KETERSEDIAAN FASILITAS DAN DUKUNGAN TENAGA KESEHATAN TERHADAP PENERAPAN KEBIASAAN CUCI TANGAN PAKAI SABUN PADA MASYARAKAT DI WILAYAH KELURAHAN SUKAMAJU BARU TAHUN 2022
Authors: Indriani Nathasya Echa , Ramadhani Nur Rizky , Nina Nina
Published: May 2024

Handwashing with soap (CTPS) is a way to remove dirt and dust from both hands with water and soap. CTPS is very useful for preventing various diseases that cause death, for example Diarrhea and Upper Respiratory Tract Infection which are very often the cause of death in children. In addition, there are also several diseases caused by the lack of habit of washing hands with soap such as Hepatitis, Covid-19, Skin and Eyes. This study aims to determine the relationship between knowledge factors, availability of facilities and support from health workers to the implementation of handwashing habits with soap in the region of sukamaju baru in 2022. This research method is descriptive quantitative using a cross sectional design. The sampling technique in this study was simple random sampling and 67 samples were obtained. The data used is primary data disseminated through online questionnaires. Data analysis was carried out univariately and bivariately using the Chi-square test. Based on statistical tests, there is 1 variable that shows a relationship, namely Knowledge with p-value = 0.010 (p<0.05) with OR = 0.240, while there are two variables that show no relationship, namely the availability of facilities with p-value = 0.417 (p>0.05) and health worker support with p-value = 0.135 (p>0.05). Based on the results of the study, it is hoped that the puskesmas with the Sukamaju Baru Village together with community leaders can work together to increase community knowledge in Sukamaju Baru Village by holding counseling and monitoring evenly in each RW so that more and more people have good knowledge and habits, especially in maintaining personal hygiene and health.
HUBUNGAN ANTARA PENGETAHUAN, SIKAP DAN PENGAWASAN TERHADAP PERILAKU PEMAKAIAN APD PADA PEKERJA PABRIK PLASTIK, PRESSING DAN CASTING PT. WIJAYA KARYA INDUSTRI & KONSTRUKSI TAHUN 2022
Authors: Ghassani Dina , Rindu Rindu , Supriyatna Rahmat
Published: May 2024

Personal Protective Equipment (PPE) is the last choice of risk for the safety and health of workers from potential hazards or accidents. To improve compliance with the use of PPE the need for supervisory factors is used to control each activity to achieve the goals that have been set. This study aims to determine the relationship between knowledge, attitudes, and supervision of the behavior of using PPE in production workers in 2022. This type of research is quantitative with a cross-sectional research design. The sample is 128 production workers. The instruments in this study used measurements and questionnaires regarding knowledge, attitudes, and supervision. Data analysis was performed univariate and bivariate using the chi-square test. Based on the results of the study, it is known that there is a significant relationship between knowledge and behavior in the use of PPE, the results of the chi-square test (p-value = 0.029 <0.05) with OR = 2.308, mean that workers with poor knowledge have the opportunity to behave badly towards the use of PPE. PPE compared to workers with good knowledge, Attitude (p = 0.008) Supervision (p = 0.007) it is also known that there is a significant relationship with the behavior of using PPE for workers in Plastic, Pressing and Casting Factory PT. Wijaya Karya Industri & Konstruksi.
PENGARUH VIDEO EDUKASI TERHADAP PENGETAHUAN SAFETY RIDING PEKERJA FINISHING PT X TANGERANG
Authors: Naranti Putri Alliya Azmi , Widjanarti Maria Paskanita , Cahyanto Erindra Budi
Published: May 2024

The number of traffic accidents that have been experienced by the workers of PT X Tangerang between 2020 and 2021 has increased and dominated by the finishing workers of PT X Tangerang. 80-85% accidents happened because of unsafe action by an individual due to lack of knowledge. This research aims to find out the effect of educational video for safety riding knowledge of finishing workers in PT X Tangerang. This research employed a quacy-experimental with a pretest-posttest control group with a respondent of 60 workers, 30 workers in each experimental and control group selected using simple random sampling technique. The result of the analysis in the experimental group using the Marginal Homogeneity test showed that there was a significant effect (p = 0,016) of the safety riding knowledge of the finishing workers before and after the intervention using the safety riding educational video. Meanwhile in the control group, there was no significant difference (p = 0,317) of safety riding knowledge based on the pre-test and post-test results. The Chi-Square test result showed the p value of 0,042 meaning that there was a significant effect of safety riding knowledge between the experimental which was given the intervention and the control group which was not. The conclusion of this study is Educational video has a significant effect towards safety riding knowledge of finishing workers in PT X Tangerang.
Analisis Kinerja PPAIW dalam Penegakan Hukum Wakaf Tanah di Indonesia
Authors: Islamiyati Islamiyati , Musyafah Aisyah Ayu , Ardani Mira Novana , Widanarti Herni
Published: May 2024

PPAIW has the main task of providing waqf administration and serving the needs of prospective wakif who will donate their assets by following per under the provisions of the legislation. The purpose of the PPAIW is so that the community gets authentic evidence that waqf has occurred. The existence of PPAIW makes waqf law change from a law that lives in the community to a written law that must be recorded by the state. However, that reality shows that PPAIW's performance in enforcing waqf law has not met the standards. The purpose of this study is to analyze the performance of PPAIW in enforcing the waqf law and formulate efforts that can be made in enforcing the waqf law. This research uses the empirical juridical method with qualitative analysis. PPAIW's performance in enforcing waqf law in Indonesia has not been by following per under good work indicators, because there are several legal problems in carrying out their obligations, so their performance is not up to standard. Efforts must be made to enforce waqf law, namely; increase PPAIW resources; realize a corruption-free government, and KKN; provide good service (good governance); guard nadzir in the land registration process; provide a decree for the appointment of nadzir; empowering nadzir and the community; mastering dispute resolution mechanisms and advocating for the community; comfortable office atmosphere and support PPAIW performance.
Prawa kobiet w Islamskim Emiracie Arabskim
Authors: Potera Natalia
Published: May 2024

Prezentowany artykuł poświęcony jest swoistej analizie zmian, jakie zachodziły w postrzeganiu statusu kobiet w Afganistanie. Państwo to, współcześnie nazywane także Islamskim Emiratem Afganistanu, jest obszarem na terenie którego poziom nierówności i dyskryminacji płciowej należy do jednych z najwyższych na świecie. Początków afgańskiej państwowości należy upatrywać już w XVIII wieku. Na przestrzeni lat lokalna społeczność stawała w obliczu licznych konfliktów zbrojnych, których podłoża należy szukać zarówno w interwencjach państw trzecich, jak i problemach wewnętrznych. Wśród nich wymienić można chociażby konflikty etniczne, czy też skrajny ekstremizm religijny.Pierwsza część artykułu zawiera analizę pozycji kobiet w świetle islamu oraz tradycji bliskowschodnich. Autorka wskazuje przy tym na dwa główne determinanty, które w sposób realny oraz znaczący oddziałują na zakres przyznawanych jednostce praw. Zalicza do nich kolejno: religię – jako czynnik kształtujący mentalność poszczególnych grup, jak również patriarchalny model społeczeństwa, determinowany przez sferę fizyczną, psychiczną, a także duchową człowieka.W drugiej części autorka opisuje zmiany społeczno-kulturowe, jakie zaszły w 2021 roku, tj. po ponownym przejęciu władzy przez Talibów. Odwołuje się przy tym do ustaw oraz rozporządzeń, jakie zostały wprowadzone w Islamskim Emiracie Arabskim.Trzecia część zawiera odniesienia do założeń prawa międzynarodowego oraz wszelkich innych aktów, obejmujących swą tematyką problematykę dyskryminacji kobiet oraz pozostałych grup defaworyzowanych w świetle prawa krajowego. Celem lepszego objaśnienia danego zagadnienia, przedstawiona zostaje także definicja terminu „dyskryminacja”.W ostatniej części pracy autorka zawarła charakterystykę aktualnej pozycji kobiet w Afganistanie, przedstawiając przy tym swoje spostrzeżenia na temat dynamiki zmian zachodzących w mentalności tamtejszej społeczności.
Techniki manipulacji wykorzystywane przez polskie media państwowe: studium przypadku ofensywy talibów w Afganistanie
Authors: Owczarek Karolina
Published: May 2024

Niniejszy artykuł ma na celu ukazanie jakimi technikami manipulacji posługiwały się media publiczne w Polsce podczas prezentowania informacji o ofensywie Talibów w Afganistanie. Do przeprowadzenia badania wykorzystano jakościową analizę źródeł, aby zebrać dane konieczne i wystarczające do odpowiedzenia na pytania badawcze, które są następujące: Jak media publiczne przedstawiały ofensywę Talibów w Afganistanie? Jakie techniki manipulacji były wykorzystywane? Niniejszy artykuł rozpoczyna się od prezentacji kontekstu badania, w którym to przedstawiona zostaje definicja nadawcy publicznego oraz jego misji. Następnie uzasadniony zostaje wybór pola badawczego oraz przedstawione narzędzie teoretyczne jakim jest typologia technik manipulacji. Następnie wyjaśnione zostają założenia metodyczne oraz przeprowadzona zostaje analiza jakościowa zawartości. Przeprowadzona analiza ukazuje, iż celem telewizji publicznej nie było sfałszowanie informacji dotyczących samych wydarzeń dziejących się w Afganistanie. Posługiwanie się technikami manipulacji miało na celu dyskredytację decyzji podejmowanych przez rząd Stanów Zjednoczonych, ocieplanie wizerunku polskiego rządu, a także byłego prezydenta USA. Ponadto techniki te były wykorzystywane do zniechęcenia Polskich obywateli do uchodźców z Afganistanu, a także ukazania ich jako niebezpiecznych.
Examining the Relationship Between Teachers' Organizational Spirituality and Their Perceptions of Job Performance
Authors: Memduhoğlu Hasan Basri , Dağ Zeynep
Published: May 2024

This study aims to examine the relationship between teachers' perceptions of organizational spirituality and their job performance. The sample of the study consisted of 728 teachers working in high schools in the central districts of Erzurum province, who were selected by stratified proportional sampling method. The data of the research were collected by the "Workplace Spirituality Scale" and the "Teacher Job Performance Scale”. Descriptive statistics, correlation and multiple regression analysis were used in the analysis of the research data. In the study, it was determined that there was a moderate positive and significant relationship between teachers' perceptions of organizational spirituality and their job performance. It was determined that organizational spirituality sub-dimensions (job passion, mysterious experience, sense of community) significantly predicted job performance. In the study, it was determined that female teachers performed more task performance than males. It was found that married teachers have a higher perception of organizational spirituality compared to single teachers. It has been found that experienced teachers show more adaptive performance compared to teachers with lower seniority. Finally, it was determined that teachers in Anatolian and science-social sciences high schools showed more 'adaptive performance' than teachers in religious vocational and vocational technical high schools.
The Predictors of Academic Motivation of University Students During COVID-19 Pandemic
Authors: Ayhan Şerife , Karacan Özdemir Nurten
Published: May 2024

Given the salience of personal and environmental-related factors in young people’s motivation during COVID-19, this study investigated if positive future expectations, social-emotional learning (SEL) skills, and perceived social support were related to university students’ intrinsic and extrinsic academic motivation and amotivation as well as if their academic motivations differed according to gender. Using a convenient sampling method, 805 university students (54% female) participated in the study in the spring semester of 2020-2021, during COVID-19 lockdowns. The results of multiple linear regression showed positive relations of positive future expectations and SEL skills with intrinsic and extrinsic academic motivations and negative relations with amotivation levels of university students. In addition, the results indicated a significant positive relationship between perceived social support and extrinsic motivation, yet no significant relation between intrinsic motivation and amotivation levels. Moreover, female students' intrinsic and extrinsic motivation levels were higher and their amotivation levels were lower than those of male students, with low effect sizes. The findings pointed to theoretical, research, and practical implications, which could be interpreted in a cultural context during COVID-19.
Investigation of The Effect of Science Activities Applied with Non-Fiction Science Picture Books on The 21st Century Skills of 60-72 Month Old Children
Authors: Doğanay Koç Esra
Published: May 2024

In this research, it is aimed to investigate impact of science activities applied with non-fiction science picture books on 21st century skills of 60-72 months old children. The study was conducted with a total of 58 children, in other words 29 children in the experimental group and 29 children in the control group. In the research, quantitative data were obtained with the 21st century skills scale which as given to children before and after the application, and the obtained data were construed by using statistical analyzes. In the light of the results obtained from the research, it can be observed that applying science acitivities through/via the non-fiction science books positively supported the 21st century skills and their sub-dimension skills such as “learning and innovation”, “living and career”, and “information-media and technology” skills of the children.
Validity and Reliability Study of the Turkish Adaptation The Certainty About Mental States Questionnaire (CAMSQ)
Authors: Usluoglu Feyruz , Bülbül Ece , Çakır Resul
Published: May 2024

The aim of this study was to examine the psychometric properties of the Turkish version of The Certainty About Mental States Questionnaire (CAMSQ). The study was conducted with 565 participants (392 women and 173 men) aged 18 and 65 from non-clinical Turkish-speaking adults. The participants were administered the Cognitive Empathy Scale of Affective and Cognitive Measure of Empathy Scale (ACME-COG), the Reflective Functioning Questionnaire (RFQ-6), and the Mentalization Scale (MentS). The concordance between the two-factor structure predicted in CAMSQ was examined with confirmatory factor analysis. The Turkish version also confirmed the analysis results, the number of items, and the two-factor structure (Self-Certainty and Other-Certainty) in the original form of the scale. There is a positive correlation between the sub-dimensions of CAMSQ and ACME-COG (0.502
Comparative toxicity assessment of fisetin-aided artificial intelligence-assisted drug design targeting epibulbar dermoid through phytochemicals
Authors: Naveed Muhammad , Abid Amina , Aziz Tariq , Saleem Ayesha , Hanif Nimra , Ali Imran , Alasmari Abdullah F.
Published: May 2024

Epibulbar dermoid, benign tumors resulting from the improper function of the pathogenic protein Patched 1 (PTCH1), surgical interventions are employed to mitigate the lethal effects. However, these procedures often lead to complications such as scleral weakening and corneal astigmatism. Due to the absence of effective medical treatments, there is a critical need for novel approaches to prevent the spread of this disease. This study not only fills a key gap in medical therapy for epibulbar dermoid, but it also demonstrates AI’s transformational potential in drug development. Employing an AI drug design service, three efficient de novo therapeutic compounds targeting the PTCH1 protein were crafted with Fisetin. The method included obtaining the PTCH1 protein sequence from NCBI, computing physiochemical parameters with Expasy Protparam, and estimating the 3D structure with SWISS-MODEL. Quality assessment, binding site prediction, drug design with WADDAICA, Lipinski’s Rule of 5, toxicity screening, ADMET evaluation, docking analysis with CB-dock and Patch dock, and MD simulations with IMOD all work together to provide an adequate basis for the development and validation of AI-designed phytochemical medicines for epibulbar dermoid. Comprehensive pharmacokinetic and toxicity assessments demonstrated the outstanding absorbency of AI-designed Fisetin in the blood–brain barrier, emphasizing its non-toxic nature. The AI-designed Fisetin exhibits a notable affinity of approximately −9.2 kcal/mol during docking with the PTCH1 protein, suggesting its potential as a drug. While the in silico results indicate efficiency and safety, the necessity for in vivo testing is acknowledged to validate these promising findings. This research significantly advances the frontier of knowledge by proposing a non-invasive solution to epibulbar dermoid, addressing current limitations, and offering potential alternatives to conventional surgical interventions.