bluuebunny/crossref_metadata_2025 huggingface dataset:
Immune checkpoint inhibition: a future guided by radiology
Authors: Khan Faraaz , Jones Keaton , Lyon Paul
Published: February 2023

The limitation of the function of antitumour immune cells is a common hallmark of cancers that enables their survival. As such, the potential of immune checkpoint inhibition (ICI) acts as a paradigm shift in the treatment of a range of cancers but has not yet been fully capitalised. Combining minimally and non-invasive locoregional therapies offered by radiologists with ICI is now an active field of research with the aim of furthering therapeutic capabilities in medical oncology. In parallel to this impending advancement, the “imaging toolbox” available to radiologists is also growing, enabling more refined tumour characterisation as well as greater accuracy in evaluating responses to therapy. Options range from metabolite labelling to cellular localisation to immune checkpoint screening. It is foreseeable that these novel imaging techniques will be integrated into personalised treatment algorithms. This growth in the field must include updating the current standardised imaging criteria to ensure they are fit for purpose. Such criteria is crucial to both appropriately guide clinical decision-making regarding next steps of treatment, but also provide reliable prognosis. Quantitative approaches to these novel imaging techniques are also already being investigated to further optimise personalised therapeutic decision-making. The therapeutic potential of specific ICIs and locoregional therapies could be determined before administration thus limiting unnecessary side-effects whilst maintaining efficacy. Several radiological aspects of oncological care are advancing simultaneously. Therefore, it is essential that each development is assessed for clinical use and optimised to ensure the best treatment decisions are being offered to the patient. In this review, we discuss state of the art advances in novel functional imaging techniques in the field of immuno-oncology both pre-clinically and clinically.
The catalytic-dead Pcif1 regulates gene expression and fertility inDrosophila
Authors: Franco Giulia , Taillebourg Emmanuel , Delfino Elena , Homolka David , Gueguen Nathalie , Brasset Emilie , Pandey Radha Raman , Pillai Ramesh S. , Fauvarque Marie-Odile
Published: February 2023

Eukaryotic mRNAs are modified at the 5′ end with a methylated guanosine (m7G) that is attached to the transcription start site (TSS) nucleotide. The TSS nucleotide is 2′-O-methylated (Nm) by CMTR1 in organisms ranging from insects to human. In mammals, the TSS adenosine can be furtherN6-methylated by RNA polymerase II phosphorylated CTD-interacting factor 1 (PCIF1) to create m6Am. Curiously, the fly ortholog of mammalian PCIF1 is demonstrated to be catalytic-dead, and its functions are not known. Here, we show thatPcif1mutant flies display a reduced fertility which is particularly marked in females. Deep sequencing analysis ofPcif1mutant ovaries revealed transcriptome changes with a notable increase in expression of genes belonging to the mitochondrial ATP synthetase complex. Furthermore, the Pcif1 protein is distributed along euchromatic regions of polytene chromosomes, and thePcif1mutation behaved as a modifier of position-effect-variegation (PEV) suppressing the heterochromatin-dependent silencing of thewhitegene. Similar or stronger changes in the transcriptome and PEV phenotype were observed in flies that expressed a cytosolic version of Pcif1. These results point to a nuclear cotranscriptional gene regulatory role for the catalytic-dead fly Pcif1 that is probably based on its conserved ability to interact with the RNA polymerase II carboxy-terminal domain.
PABPN1 prevents the nuclear export of an unspliced RNA with a constitutive transport element and controls human gene expression via intron retention
Authors: Kwiatek Lauren , Landry-Voyer Anne-Marie , Latour Mélodie , Yague-Sanz Carlo , Bachand Francois
Published: February 2023

Intron retention is a type of alternative splicing where one or more introns remain unspliced in a polyadenylated transcript. Although many viral systems are known to translate proteins from mRNAs with retained introns, restriction mechanisms generally prevent export and translation of incompletely spliced mRNAs. Here, we provide evidence that the human nuclear poly(A)-binding protein, PABPN1, functions in such restrictions. Using a reporter construct in which nuclear export of an incompletely spliced mRNA is enhanced by a viral constitutive transport element (CTE), we show that PABPN1 depletion results in a significant increase in export and translation from the unspliced CTE-containing transcript. Unexpectedly, we find that inactivation of poly(A)-tail exosome targeting by depletion of PAXT components had no effect on export and translation of the unspliced reporter mRNA, suggesting a mechanism largely independent of nuclear RNA decay. Interestingly, a PABPN1 mutant selectively defective in stimulating poly(A) polymerase elongation strongly enhanced the expression of the unspliced, but not of intronless, reporter transcripts. Analysis of RNA-seq data also revealed that PABPN1 controls the expression of many human genes via intron retention. Notably, PABPN1-dependent intron retention events mostly affected 3′-terminal introns and were insensitive to PAXT and NEXT deficiencies. Our findings thus disclose a role for PABPN1 in restricting nuclear export of intron-retained transcripts and reinforce the interdependence between terminal intron splicing, 3′ end processing, and polyadenylation.
Determinantes dos prazos das compras públicas por meio de pregão eletrônico
Authors: Gonçalves Marivaldo de Sousa , Figueiredo Paulo
Published: February 2023

O presente estudo teve como objetivo identificar fatores determinantes dos prazos das licitações públicas. Foram formuladas hipóteses com base na lógica dos leilões e no referencial teórico das compras públicas e da área específica de licitações e contratos públicos, utilizando dimensões características do bem, do procedimento e do fornecedor. A proposta foi realizar uma análise das contratações públicas buscando elucidar fatos, com o propósito de minimizar os prazos visando à maioreficiência. A coleta de dados deu-se em quatro unidades técnicas da Fundação Oswaldo Cruz, extraídos pelo sistema de compras governamentais, no período de 2011 a 2019, com uma população substancial dos eventos de licitação ocorridos por pregão eletrônico. Os dados foram analisados por análise paramétrica e multivariada, por meio de regressão múltipla. Os resultados apontam para diversos fatores que influenciam de maneira positiva os prazos, aumentando-os, fatores que, quando bem administrados, podem mitigar esses prazos. O estudo traz contribuições para a área de políticas públicas, podendo ajudar pesquisadores focados no tema de licitações públicas e auxiliar formuladores de políticas de governo.
The genome sequence of the lesser worm flesh fly, Sarcophaga (Sarcophaga) subvicina (Baranov, 1937)
Authors: Falk Steven ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life programme,   Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective,   Tree of Life Core Informatics collective, Mulley John F. ,   Darwin Tree of Life Consortium
Published: February 2023

We present a genome assembly from an individual male Sarcophaga subvicina (the lesser worm flesh fly; Arthropoda; Insecta; Diptera; Sarcophagidae). The genome sequence is 71 megabases in span. Most of the assembly (95.91%) is scaffolded into six chromosomal pseudomolecules, with the X sex chromosome assembled. The mitochondrial genome has also been assembled and is 16.7 kilobases in length. Gene annotation of this assembly on Ensembl identified 16,793 protein coding genes.
Military epidemiology. Study guide
Authors: Shulev P.L. , Kosova A.A. , Slobodenyuk A.V. , An R.N. , Makarov A.E.
Published: February 2023

Электронный образовательный ресурс составлен в соответствии с требованиями Федерального государственного образовательного стандарта высшего образования специальность 32.05.01 Медико-профилактическое дело, утвержденным приказом Министерства образования и науки Российской Федерации от 16 января 2017 г. №21, и с учетом требований профессионального стандарта 02.002 «Специалист в области медико-профилактического дела», утвержденного приказом Министерства труда и социальной защиты Российской Федерации от 25 июня 2015 г. №399н. Цель изучения курса – Дать обучающимся знания основ по военной эпидемиологии, выработать умения, необходимые для освоения выпускниками компетенций в соответствии с Федеральным государственным образовательным стандартом высшего образования, по специальности 32.05.01 – медико-профилактическое дело, способных и готовых к выполнению трудовых функций, требуемым профессиональным стандартом «Специалист в области медико-профилактического дела». Задачи изучения дисциплины: 1. формирование у выпускников знаний по теоретическим вопросам военной эпидемиологии; 2. подготовка специалиста, обладающего профессиональными компетенциями к самостоятельному проведению профилактической, организационно-управленческой деятельности в области военной эпидемиологии; 3. формирование у выпускника навыков самостоятельной работы с современными информационными технологиями обучения, работы с интернет - источниками; 4. подготовка специалиста, владеющего умениями использования нормативных документов для формулирования экспертных заключений по вопросам профилактики инфекционных заболеваний; 5. формирование у выпускника умения применять на практике знания доказательной медицины в военной эпидемиологии; 6. привлечение выпускников к научным исследованиям, направленным на решение фундаментальных и прикладных задач по вопросам эпидемиологии инфекционной и паразитарной патологии.
The use of visual images in the study of Philosophy (pictorial method)
Authors: Vlasova E.V.
Published: February 2023

Книга представляет собой учебно-методическое пособие, которое знакомит преподавателей философии с основными принципами и приёмами использования оригинальной авторской методики, позволяющей активизировать образное мышление студентов в процессе изучения курсов философии и истории философии.Издание предназначено для студентов медицинских и фармацевтических вузов, а также для тех, кто интересуется философией. Русское издание получило в 2013 гриф ФИРО, имеет три золотые медали международных книжных выставок. Русская книга выдержала 4 издания. Перевод выполнен носителем языка.
Online course "Molecular phisica"
Authors: Neskoromnyi Sergei , Pervuhin Nikolai
Published: February 2023

Задачи курса состоят в том, чтобы студенты обучающиеся на специальности 33.05.01 ""Фармация"" овладели базовыми знаниями о фундаментальных основах молекулярной физики. Курс посвящен изучению и практическому применению физических закономерностей для изучения химических и фармацевтических дисциплин.
English. Textbook for students of the Faculty of Preventive Medicine
Authors: Kolotnina Elena , Olshvang Olga
Published: February 2023

Пособие предназначено для обучения студентов 1 курса медико-профилактического факультета и в полной мере выполняет задачи формирования компетенций, которыми должны обладать будущие профессионалы. Аутентичные материалы и разработанные на их основе авторские задания позволяют вести обучение иностранному языку с учетом современных требований подготовки специалистов, а также использовать данное учебное пособие как для аудиторной, так и для самостоятельной работы. Пособие обладает четкой структурой, состоит из разделов, каждый из которых содержит достаточное количество заданий, направленных на формирование необходимых компетенций и навыков, особое внимание уделяется работе со специальной медицинской лексикой. Пособие содержит глоссарий и грамматический справочник, необходимый для освоения заявленного материала. Особенностью пособия является изучение элементов структуры исследовательской статьи. Каждый раздел пособия содержит задания, нацеленные на развитие коммуникативных навыков студентов, изучающих медицинский английский язык.
Electronic educational resource "Actual issues of epidemiology and prevention of infections associated with the provision of medical care for doctors of clinical specialties"
Authors: Kosova Anna , Slobodenyuk Aleksandr , An Rozaliya , Smirnova Svetlana , Makarov Anton , Nechitajlo Aleksandr , Zornikov Danila , Kuznecov Pavel , Boronina Lyubov , Bogushevich Yuliya , Gazimova Venera
Published: February 2023

Данный электронно-образовательный ресурс (ЭОР) предназначен для лиц, имеющих высшее медицинское образование. Цель обучения - совершенствование трудовых функций и профессиональных компетенций врачей клинических специальностей по вопросам эпидемиологии и профилактики инфекций, связанных с оказанием медицинской помощи (ИСМП) путем совершенствования компетенций, необходимых для профессиональной деятельности и повышения профессионального уровня в рамках имеющейся квалификации. Задачи: 1. Обновление существующих у специалиста теоретических знаний, методик и изучение передового практического опыта по вопросам эпидемиологии и профилактики инфекций, связанных с оказанием медицинской помощи (ИСМП). 2. Обновление и закрепление на практике профессиональных знаний, умений и навыков, обеспечивающих совершенствование профессиональных компетенций по вопросам осуществления профилактических и противоэпидемических мероприятий необходимых для выполнения профессиональных задач в рамках имеющейся квалификации. Содержание. Курс состоит из 4 модулей, содержащих теоретический и практический материал, а также тестовые контроли. Рассматриваются вопросы эпидемиологии инфекций, связанных с оказанием медицинской помощи, эпидемиологическим надзором, а также мероприятия по профилактике ИСМП, вопросы профессиональных заражений медицинского персонала. Теоретическая часть представлена в виде лекций и практикумов. В контрольном блоке для проверки уровня усвоения теоретического материала обучающемуся предлагается ответить на тестовый контроль и решить ситуационные задачи.
Prevention and early orthodontic treatment of dental anomalies in children with impaired functions of the dental system
Authors: Bimbas E.S. , Shishmareva A.S.
Published: February 2023

Данный интерактивный обучающий модуль предназначен для врачей детских стоматологов, стоматологов общей практики, ортодонтов, будет полезен студентам стоматологического факультета, ординаторам. Цель данного модуля: повышение квалификации по специальности «Детская стоматология» и «Ортодонтия»; обновление знаний об особенностях профилактики и раннего ортодонтического лечения детей с нарушениями функций; этиологии и патогенеза зубочелюстных аномалий, связанных с нарушениями функций ЧЛО; описание клинических случаев, иллюстрирующих раннее ортодонтическое лечение детей с нарушениями функций зубочелюстной системы; овладение методами лечения зубочелюстных аномалий у детей с нарушениями функций, включая авторские; определение алгоритмов комплексного раннего ортодонтического лечения, адаптированного на детей раннего возраста. Модуль содержит теоретические, практические и контролирующие материалы по профилактике и раннему лечению детей с нарушениями функций: дыхания, глотания; с нарушениями миодинамического равновесия ЧЛО; с приобретенными «вредными» привычками. Модуль позволит сформировать у обучающихся профессиональные навыки, научит объединять в единое целое разные методики профессиональной направленности; подготовит слушателей к использованию и применению полученных знаний и умений в профессиональной деятельности.
Electronic educational resource "Obstetrics and gynecology"
Authors: Lavrentieva Inna , Prohorova Olga
Published: February 2023

Электронный курс ""АКУШЕРСТВО И ГИНЕКОЛОГИЯ"" для студентов 4 курса стоматологического, педиатрического и медико-профилактического факультетов составлен в соответствии с требованиями ФГОС ВО по направлению подготовки (специалитет) 31.05.03 «Стоматология», утвержденного приказом Министерства образования и науки Российской Федерации от 09.02.2016 N 96; ФГОС ВО по направлению подготовки (специалитета) 31.05.02 «Педиатрия», утвержденным приказом Министерства образования и науки Российской Федерации от 17.08.2015 г. № 853. и специальности 32.05.01 Медико-профилактическое дело, утвержденного приказом Министерства образования и науки Российской Федерации от 16.01.2017 N 21 (в ред. от 13.07.2017 г.) Цель - сформировать у студента навыки обследования, лечения и наблюдения женщин в период беременности и родов и с гинекологическими заболеваниями Задачи: - ознакомление студентов с нормами течения беременности, родов и послеродового периода - изучение основных патологических состояний во время беременности - освоение методов оказания неотложной помощи при патологическом течении родов и послеродового периода - ознакомление с основными гинекологическими заболеваниями Трудоемкость 144 ч. 36ЗЕТ
Dies irae: ¿Por qué las democracias liberales no logran domesticar la ira y la violencia?
Authors: Garzón Vallejo Iván
Published: February 2023

El siglo XXI ha estado marcado por innumerables protestas callejeras en diferentes regiones del mundo desatadas a su vez por disímiles coyunturas políticas. El artículo tiene dos objetivos: primero, proponer las emociones políticas de la rabia, el resentimiento y el deseo de reconocimiento como categorías interpretativas de las expresiones de inconformidad ciudadanas frente a la política contemporánea. Segundo, advertir que la incapacidad de las democracias liberales para domesticar la violencia constituye uno de los mayores fracasos de la modernidad política. Así, a partir de la lectura crítica de los filósofos políticos contemporáneos más relevantes en el ámbito occidental, ambos objetivos mostrarán que la crisis de las democracias liberales y del capitalismo tiene raíces estructurales y que demandan la reinvención del paradigma triunfante en 1989 conocido como el Fin de la Historia.
La lucha por la supervivencia y la creaciÃ³n de un nuevo pacto social comÃºn: una prueba hobbesiana basada en el case method de L. Fuller
Authors: Manzanero FernÃ¡ndez Delia
Published: February 2023

El artÃ­culo ilustra la utilizaciÃ³n del case method a travÃ©s de una investigaciÃ³n socio-educativa reciente donde se traza una analogÃ­a entre el caso de los exploradores de L. Fuller con la situaciÃ³n vital marcada por la pandemia. A tal efecto, pasa revista a cuestiones radicales que se desataron ante la urgencia de un problema cardinal de supervivencia y de salud pÃºblica que dejÃ³ todo lo demÃ¡s (derecho, convenciones, moralidad, libertades) en la sombra y plantea algunos dilemas Ã©tico-jurÃ­dicos desencadenados bajo ciertas situaciones consideradas de emergencia extrema donde la supervivencia de todos estÃ¡ en juego. Frente a la trampa hobbesiana de un supuesto estado de naturaleza por el cual es justificable cualquier tipo de ataque preventivo o violencia, en el artÃ­culo se trata de argumentar, al hilo de las respuestas dadas al caso jurÃ­dico de Fuller, nuevas formas de entender la comunidad, el pacto social, lo pÃºblico y lo polÃ­tico.
La IlustraciÃ³n india: sus orÃ­genes, naturaleza e ideas
Authors: LÃ³pez Areu Mario
Published: February 2023

Este trabajo estudia el desarrollo de la IlustraciÃ³n india, cuyas ideas reformistas sientan las bases del pensamiento polÃ­tico indio moderno. Su auge coincide con la expansiÃ³n del gobierno de la CompaÃ±Ã­a de las Indias Orientales britÃ¡nica y de las ideas orientalistas ilustradas. El colonialismo, defendemos, espolea un debate entre la intelectualidad india acerca del orden social tradicional y la necesidad de su reforma. El artÃ­culo hace una distinciÃ³n entre una IlustraciÃ³n india moderada, que desea modernizar India manteniendo sus raÃ­ces civilizatorias, y una radical, que busca reformular todo el edificio social y filosÃ³fico. Para ello, se estudia el pensamiento y activismo de dos destacados ilustrados indios, el liberal Rammohun Roy y el radical Jotirao Phule. El artÃ­culo concluye que la IlustraciÃ³n india es una IlustraciÃ³n por derecho propio, que, aunque bebe y dialoga con la modernidad occidental, desarrolla sus propios debates y propuestas de reforma. El trabajo tambiÃ©n busca contribuir a la expansiÃ³n de la historia intelectual de la IlustraciÃ³n fuera de Occidente.
El virus cultural posmoderno: origen, variantes y posibles vacunas
Authors: IbÃ¡Ã±ez Alberto G.
Published: February 2023

Existe una guerra cultural que pretende la destrucciÃ³n de Occidente utilizando como caballo de Troya el enemigo interno del â€œvirus cultural posmodernoâ€. Se analiza el origen complejo de dicho virus, con mÃ¡s de una cepa, sin descartar la posibilidad de que fuera diseÃ±ado en un laboratorio. Apelando a acabar con las verdades fuertes, el â€œpensamiento culturalmente correctoâ€ impone su propia verdad fuerte sin buscar acuerdo ni sÃ­ntesis con quien piensa diferente. Se examinan sus principales variantes que se caracterizan por la ausencia de lÃ­mites y un exceso de contradicciones que producen el aumento de la polaridad, la confusiÃ³n y la fragilidad. Para contrarrestar todo ello, el artÃ­culo plantea algunas posibles vacunas en torno a la idea de un renacimiento cultural y un nuevo equilibrio entre modernidad y tradiciÃ³n.
Contrapunto de Estado desde BolÃ­var EcheverrÃ­a
Authors: Bruna Castro Carolina
Published: February 2023

En el presente texto intento mostrar elementos relevantes que BolÃ­var EcheverrÃ­a toma del marxismo crÃ­tico para reflexionar sobre conceptos de la filosofÃ­a polÃ­tica como, por ejemplo, el Estado. La motivaciÃ³n de este texto es abordar las definiciones de instituciones que nos permitan pensar nuestras relaciones sociales. Si bien no propongo aquÃ­ una nueva institucionalidad, considerarÃ© cÃ³mo los conceptos elaborados por EcheverrÃ­a de modernidad, identidad y blanquitud nos permiten criticar el concepto de Estado y su alcance como la instituciÃ³n bajo la cual se pretende encontrar algo de cohesiÃ³n social.
Prospects for the Potential of Underground Coal Mining in after War Strengthening the Defense Capability of the State
Authors:   Institute of Industrial Economics of the NAS of Ukraine, Liashenko V. , Stolyarov V. ,   Institute of Physical Economy named after S. A. Podolynskyi
Published: February 2023

In the article, on the example of the coal industry of Ukraine, internal reserves of indirect, mediated action on strengthening the defense capability of the state are considered. On the basis of the conceptual provisions of the structural-reproductive approach to the definition of the composite assets of mines, certain elements of the investment mechanism for conducting mining and preparation works for underground coal mining are substantiated. Proposals for the use of mine workings and underground structures of mines as warehouses or production workshops of the military-industrial complex are presented. The article reveals the essence, content and components of the potential of the state's defense capability in the parameters of the socio-economic space of Ukraine. It is emphasized that it is the level, standards and quality of life of the population of the country that determine and determine the ability of the state to protect itself from external armed aggression in the event of an internal armed conflict. The methodological provisions of the reference matrix of the index model of strategic planning and design of the state's defense potential in the parameters of the socio-economic space of Ukraine are outlined. They are based on new principles of strategic planning of socio-economic development and new principles of state creation.
Spatial Management of Sustainable Management in Critical Infrastructure in a Special Period
Authors:   Institute of Environmental Economics and Sustainable Development of the NAS of Ukraine, Mykytenko V. , Drachuk Yu. ,   Institute of Industrial Economics of the NAS of Ukraine
Published: February 2023

The article proposes to use the methodological provisions for the development and implementation in practice of a spatial three-level complex of monitoring programs (general/standard, operational/crisis and background/scientific), which was formed taking into account the current geopolitical and internal economic situation in the state according to the block principle of configurational transformation in the quality of the National Spatial System for Monitoring the Effectiveness of Management of Sustainable Management in Critical Infrastructure. The target activity of the National Monitoring System has been formulated, which should be aimed at: a) organization of information support at the level of decision-making and control over the execution of assignments and the creation of a permanent information testing ground for critical infrastructure objects; b) obtaining, in addition to technical-economic, technological and financial information, also information related to the dynamics of threats to the sustainable management of critical infrastructure and its submission to state bodies, management and management entities, etc.; c) the use of measures directly aimed at increasing the level of protection against identified threats and risks, which should be successfully used for decision-making in various economic and business processes. The main provisions of the cybernetic theory were used to determine the key problems of critical infrastructure in the unstable conditions of economic and military aggression, which makes it possible to consider the self-organization of the state entity as a process of achieving a dynamic balance between the management system of sustainable management in critical infrastructure and its environment.
Investment Activities in Ukraine and its Impact on the National Economy
Authors:   Dnipropetrovsk State University of Internal Affairs, Razumova А. , Oskoma O. ,   Ukrainian State University of Chemical Technology, Peretiatko K. ,   Dnipropetrovsk State University of Internal Affairs
Published: February 2023

The article analyzes the volume and structure of direct foreign investment in the economy of Ukraine. Factors that negatively affect investment attractiveness and the investment climate in Ukraine are presented and analyzed. It was established that in Ukraine there is a significant imbalance in investments by regions of the country – two-thirds of foreign funds are invested in enterprises of four regions, which has a negative impact on the national economy development. Proposals have been developed to increase the investment attractiveness of Ukraine in the post-war period, in particular, to create the most comfortable conditions for investment, which will make it possible to compensate for the damage caused by the war.
Forming of Investment Attractiveness and Providing of Economic Efficiency of Corporate Integration Association
Authors:   Private Higher Education Institution ", Hutsaliuk O. ,   Rauf Ablyazov East European University", Bondar Iu. ,   Flight Academy of the National Aviation University, Popov O. ,   Kharkiv State Academy of Physical Culture
Published: February 2023

The development of joint-stock companies in the context of the development of the management mechanism of corporate enterprises and the formation of properly functioning corporate associations is determined by the existing potential and prospects for expanding the range of strategic and current goals and is a relevant research of today. The purpose of the research in the work is theoretical substantiation and development of recommendations for the formation of investment attractiveness of the corporate integration association. It is proven that the selection and justification of the optimal composition of the sources of capital formation of the corporation allows: to ensure the differentiation of sources of investment resources according to the program objectives of the chosen strategy; determine the set of the most desirable sources of capital formation; to specify directions of resource use. It was established that the formation of the investment attractiveness of corporate enterprises at various stages of its life cycle depends on many factors, such as the cost of the source, the availability of the source, the image of the association in front of suppliers of financial resources, the amount of own assets suitable for reinvestment. It was established that the implementation of integration operations is an important element of the general context of social and economic development of corporate enterprises, which requires the formation of an appropriate strategic basis for maintaining investment attractiveness and ensuring the economic efficiency of corporate enterprises. The results of the conducted research allow us to draw conclusions that the formation of capital and investment attractiveness of a corporate association depends on taking into account in the process of formation and development of the integration structure the peculiarities of the organizational and legal form of joint-stock companies that are participants in corporate enterprises.
A ‘Golden Age’ Of Architecture
Authors: Edwards Chris
Published: February 2023

Tuned silicon attempts to make a comeback with small SoCs.
Bankable Star
Authors: Stone Tom , Roper Jack
Published: February 2023

At the heart of tolling is revenue collection. So it should come as no surprise that Florida Turnpike Enterprise’s CEO Nicola Liquori is making it her latest mission to oversee the building of a new back-office system that will ensure income is secured more seamlessly than ever before
Of The Best
Authors: Johns Derek
Published: February 2023

CONEXPO 2020 SHOWCASED A HOST OF NEW MACHINES, MANY OF WHICH REFLECTED THE GLOBAL SHIFT TOWARDS ELECTRIC VEHICLES. WE PICK FIVE STANDOUT DEBUTS
Joined-Up Thinking
Authors: Allevi Matteo
Published: February 2023

IN THE VAST AND VARIED FIELD OF HYDRAULIC FLUID POWER, THERE IS A GROWING NEED FOR QUICK-RELEASE COUPLINGS. BUT WHICH REPRESENT THE BEST CHOICE FOR VEHICLE DESIGNERS?
Electromechanical Power
Authors: Bonelli Davide
Published: February 2023

MODULAR ELECTRICAL CENTERS CAN HELP TO SAFELY DISTRIBUTE POWER IN MACHINERY AND VEHICLES USED IN OFF-ROAD APPLICATIONS
New Power Generation
Authors: Stone Tom
Published: February 2023

PETER GRANQVIST, VOLVO PENTA'S NEW CHIEF TECHNOLOGY OFFICER, TALKS ABOUT THE COMPANY'S LATEST STAGE V ENGINES AND SPECULATES ON HOW THE TRIPLE REVOLUTIONS OF ELECTRIFICATION, CONNECTIVITY AND AUTOMATION WILL HELP SHAPE THE POWERTRAINS OF THE FUTURE
Smarter Hydraulic Control
Authors: Kokkinen Pasi
Published: February 2023

OPERATING TRAILERS WITH HYDRAULIC WHEEL MOTORS FROM A TRACTOR CAB CAN BE SIMPLIFIED SIGNIFICANTLY USING NEW ISOBUS-COUPLED SYSTEMS THAT HELP TO ENSURE ALL WHEELS MOVE IN UNISON
Dashboard for All
Authors: Golinelli Davide
Published: February 2023

A NEW DASHBOARD DESIGNED FOR THE AGRICULTURE SECTOR STREAMLINES THE USER EXPERIENCE WITH CUSTOMIZABLE PROGRAMS AND APPEARANCE
Advanced, Zero-Emission Axles
Authors: Dearden Andrew
Published: February 2023

BY USING SEALED, OIL-IMMERSED BALL RAMP ACTUATED BRAKING, A NEW GENERATION OF ADVANCED AXLES IS ENSURING THAT HEAVY-DUTY VEHICLES CAN BE TRULY EMISSION FREE, WITHOUT COMPROMISING COMFORT, SAFETY OR PERFORMANCE
Surface figure measurement tool based on a radial shearing interferometer using a geometric phase lens with various spherical wavefronts
Authors: Mi Park Hyo , Joo Ki-Nam
Published: February 2023

We describe a compact radial shearing interferometer based on a geometric phase lens as a surface figure measurement tool. Based on the polarization and diffraction characteristics of a geometric phase lens, two radially sheared wavefronts are simply generated, and the surface figure of a specimen can be immediately reconstructed from the radial wavefront slope calculated with four phase-shifted interferograms obtained from a polarization pixelated complementary metal-oxide semiconductor camera. In order to increase the field of view, moreover, the incident wavefront is adjusted according to the shape of the target, which allows the reflected wavefront to become planar. By the combination of the incident wavefront formula and the measurement result by the proposed system, the whole surface figure of the target can be instantaneously reconstructed. As the experimental result, the surface figures of various optical components were reconstructed at the extended measurement area with less than 0.78 µm deviations, and it was confirmed that the radial shearing ratio was fixed independent of the surface figures.
AlphaFold2-multimer guided high-accuracy prediction of typical and atypical ATG8-binding motifs
Authors: Ibrahim Tarhan , Khandare Virendrasinh , Mirkin Federico Gabriel , Tumtas Yasin , Bubeck Doryen , Bozkurt Tolga O.
Published: February 2023

Macroautophagy/autophagy is an intracellular degradation process central to cellular homeostasis and defense against pathogens in eukaryotic cells. Regulation of autophagy relies on hierarchical binding of autophagy cargo receptors and adaptors to ATG8/LC3 protein family members. Interactions with ATG8/LC3 are typically facilitated by a conserved, short linear sequence, referred to as the ATG8/LC3 interacting motif/region (AIM/LIR), present in autophagy adaptors and receptors as well as pathogen virulence factors targeting host autophagy machinery. Since the canonical AIM/LIR sequence can be found in many proteins, identifying functional AIM/LIR motifs has proven challenging. Here, we show that protein modelling using Alphafold-Multimer (AF2-multimer) identifies both canonical and atypical AIM/LIR motifs with a high level of accuracy. AF2-multimer can be modified to detect additional functional AIM/LIR motifs by using protein sequences with mutations in primary AIM/LIR residues. By combining protein modelling data from AF2-multimer with phylogenetic analysis of protein sequences and protein–protein interaction assays, we demonstrate that AF2-multimer predicts the physiologically relevant AIM motif in the ATG8-interacting protein 2 (ATI-2) as well as the previously uncharacterized noncanonical AIM motif in ATG3 from potato (Solanum tuberosum). AF2-multimer also identified the AIM/LIR motifs in pathogen-encoded virulence factors that target ATG8 members in their plant and human hosts, revealing that cross-kingdom ATG8-LIR/AIM associations can also be predicted by AF2-multimer. We conclude that the AF2-guided discovery of autophagy adaptors/receptors will substantially accelerate our understanding of the molecular basis of autophagy in all biological kingdoms.
Cloudiness delays projected impact of climate change on coral reefs
Authors: González-Espinosa Pedro C. , Donner Simon D.
Published: February 2023

The increasing frequency of mass coral bleaching and associated coral mortality threaten the future of warmwater coral reefs. Although thermal stress is widely recognized as the main driver of coral bleaching, exposure to light also plays a central role. Future projections of the impacts of climate change on coral reefs have to date focused on temperature change and not considered the role of clouds in attenuating the bleaching response of corals. In this study, we develop temperature- and light-based bleaching prediction algorithms using historical sea surface temperature, cloud cover fraction and downwelling shortwave radiation data together with a global-scale observational bleaching dataset observations. The model is applied to CMIP6 output from the GFDL-ESM4 Earth System Model under four different future scenarios to estimate the effect of incorporating cloudiness on future bleaching frequency, with and without thermal adaptation or acclimation by corals. The results show that in the low emission scenario SSP1-2.6 incorporating clouds into the model delays the bleaching frequency conditions by multiple decades in some regions, yet the majority (>70%) of coral reef cells still experience dangerously frequent bleaching conditions by the end of the century. In the moderate scenario SSP2-4.5, however, the increase in thermal stress is sufficient to overwhelm the mitigating effect of clouds by mid-century. Thermal adaptation or acclimation by corals could further shift the bleaching projections by up to 40 years, yet coral reefs would still experience dangerously frequent bleaching conditions by the end of century in SPP2-4.5. The findings show that multivariate models incorporating factors like light may improve the near-term outlook for coral reefs and help identify future climate refugia. Nonetheless, the long-term future of coral reefs remains questionable if the world stays on a moderate or higher emissions path.
Healthcare-seeking experiences of older citizens in Bangladesh: A qualitative study
Authors: Sarker Abdur Razzaque , Zabeen Irfat , Khanam Moriam , Akter Ruckshana , Ali Nausad
Published: February 2023

Despite improvements in many health indicators in the last few decades, providing access to affordable and quality healthcare for older citizen remains a considerable challenge in Bangladesh. This study aimed to understand individuals ‘experiences regarding their healthcare-seeking, treatment cost, accessibility and coping mechanisms for the promotion of appropriate strategies to enhance the quality of life of the older citizens of Bangladesh.A qualitative descriptive approach was used in this study. A total of 27 In-Depth Interviews (IDIs) were conducted in a district in Bangladesh with older people between January and February 2020, where gender distribution was equal. Face-to-face interviews were conducted by trained and experienced interviewers regarding healthcare-seeking and accessibility, affordability, and healthcare coping strategy. Thematic analysis was conducted to analyse the data. It was found that the health condition of the older population is not satisfactory. Most of them had been suffering from several diseases such as benign tumor, chronic kidney disease, body aches, gastric ulcers for a longer period of time. The majority of the participants were suffering from multiple non-communicable diseases while diabetes and hypertension were the foremost of all diseases. This study provides insight into the challenges of managing healthcare services for older citizens in Bangladesh. Healthcare facilities were available, but high out-of-pocket payments, lack of caregivers, and time distance created a barrier to the service provision. The findings indicated that geriatric care policymakers and service providers should prioritize the older-friendly health infrastructures with affordable cost of treatment for the betterment of the health status of older citizens in Bangladesh.
Territorial differences in the spread of COVID-19 in European regions and US counties
Authors: Natale Fabrizio , Iacus Stefano Maria , Conte Alessandra , Spyratos Spyridon , Sermi Francesco
Published: February 2023

This article explores the territorial differences in the onset and spread of COVID-19 and the excess mortality associated with the pandemic, with a focus on European regions and US counties. Both in Europe and in the US, the pandemic arrived earlier and recorded higher Rt values in urban regions than in intermediate and rural ones. A similar gap is also found in the data on excess mortality. In the weeks during the first phase of the pandemic, urban regions in EU countries experienced excess mortality of up to 68 pp more than rural ones. We show that, during the initial days of the pandemic, territorial differences in Rt by the degree of urbanisation can be largely explained by the level of internal, inbound and outbound mobility. The differences in the spread of COVID-19 by rural-urban typology and the role of mobility are less clear during the second wave. This could be linked to the fact that the infection is widespread across territories, to changes in mobility patterns during the summer period as well as to the different containment measures which reverse the link between mobility and Rt.
The usefulness of change in CT score for evaluating the activity of Mycobacterium abscessus (Mab) pulmonary disease (Mab-PD)
Authors: Shinfuku Kyota , Hara Hiromichi , Takasaka Naoki , Ishikawa Takeo , Araya Jun , Kuwano Kazuyoshi
Published: February 2023

Objectives

Semi-quantitative CT score is generally used for evaluating the disease status of Mycobacterium abscessus (Mab) Pulmonary disease (Mab-PD). However, its accuracy and clinical usefulness are limited, since the CT score is largely affected by coexisting lung disease. Hence, we hypothesized that numerical change in CT score during the observation period may be useful for evaluating disease activity of Mab-PD.

Methods

Patients diagnosed with Mab-PD based on the official ATS/ERS/ESCMID/IDSA statement at Jikei University Hospital and Jikei Daisan Hospital between 2015 January 1 and 2021 July 31 were included (n = 32). We reviewed the medical records, and bacteriological and laboratory data of the patients. Chest CT was performed at diagnosis in all 32 cases. In 18 cases, chest CT images within 4 years before diagnosis were available. The numerical change in CT score between two time points was calculated and the association of the CT scores with sputum Gaffky score and serum CRP was examined.

Results

CT score at diagnosis was not correlated with sputum Gaffky score nor serum CRP, while the difference of absolute value and change rate in CT score between at diagnosis and immediate past CT were well correlated with both sputum Gaffky score and serum CRP.

Conclusions

Chronological change in CT score may more precisely reflect the disease activity of airway mycobacterial burden and systemic inflammation in Mab-PD at the timing of diagnosis.
Biomarkers for prediction of neurological complications after acute Stanford type A aortic dissection: A systematic review and meta-analysis
Authors: Si Yi , Duan Weixun , Xie Jiangang , Duan Chujun , Liu Shanshou , Wang Qianmei , Zhao Xiaojun , Wu Dan , Wang Yifan , Wang Lingxiao , Li Junjie
Published: February 2023

Background

The predictive value of biomarkers such as neuron specific enolase (NSE), S100B, neurofilament (NFL), interleukin-6 (IL-6), coagulation factor R, and D-Dimer (DD) after acute Stanford A type aortic dissection (AAAD) with neurological complications has recently gained much attention from the research community. However, results from these studies are conflicting. This meta-analysis is conducted to assess the relationship between the biomarkers and the risk of neurological complications after AAAD.

Methods

Two reviewers performed a systematic literature search across eight databases (CNKI, Wan Fang, VIP, CBM, PubMed, Web of Science, Cochrane Library, and EMBASE). The studies regarding biomarkers in AAAD patients published up to February 2022 were included. These studies were subjected to rigorous scrutiny and data extraction to determine the weighted mean difference (WMD) and the 95% confidence interval (CI), which were analyzed using the RevMan 5.4 and Stata software 14.0.

Results

A total of 12 studies including 360 cases with neurological complications and 766 controls were incorporated into our meta-analysis. WMD analysis showed that there was a higher NSE levels in AAAD patients with postoperative neurological complications compared with controls (WMD = 0.640, 95% CI: 0.205 ~ 1.075, P = 0.004 < 0.005), and the level of S100B was related to the 6 h and 24 h postoperative neurological complications (6 h: WMD = 0.64, 95% CI: 0.27 ~ 1.02, P = 0.0007 < 0.001; 24 h: WMD = 0.281, 95% CI: 0.211 ~ 0.351, P < 0.001). Moreover, S100B levels at 6 hours after operation were significantly higher than that at 24 hours (WMD = 0.260, 95% CI: 0.166 ~ 0.354, P < 0.001).

Conclusion

NSE and S100B are both candidate biomarkers to predict postoperative neurological complications in patients with AAAD. Other markers are also valuable when used in conjunction with clinical judgement. The findings accentuate the necessity of further research to establish standardized values for these biomarkers in predicting neurological complications.
STI testing and subsequent clinic attendance amongst test negative asymptomatic users of an internet STI testing service; one-year retrospective study
Authors: Ayinde Oluseyi , Jackson Louise , Phattey Jara , Ross Jonathan D. C.
Published: February 2023

Aim

To explore the characteristics of online STI test users, and assess the frequency and factors associated with subsequent service use following a negative online STI test screen in individuals without symptoms.

Methods

One-year retrospective study of online and clinic STI testing within a large integrated sexual health service (Umbrella in Birmingham and Solihull, England) between January and December 2017. A multivariable analysis of sociodemographic and behavioural characteristics of patients was conducted. Sexual health clinic appointments occurring within 90 days of a negative STI test, in asymptomatic individuals who tested either online or in clinic were determined. Factors associated with online STI testing and subsequent clinic use were determined using generalized estimating equations and reported as odds ratios (OR) with corresponding 95% confidence intervals (CI).

Results

31 847 online STI test requests and 40 059 clinic attendances incorporating STI testing were included. 79% (25020/31846) of online STI test users and 49% (19672/40059) of clinic STI test takers were asymptomatic. Online STI testing was less utilised (p<0.05) by men who have sex with men (MSM), non-Caucasians and those living in neighborhoods of greater deprivation. Subsequent clinic appointments within 90 days of an asymptomatic negative STI test occurred in 6.2% (484/7769) of the online testing group and 33% (4960/15238) for the clinic tested group. Re-attendance following online testing was associated with being MSM (aOR 2.55[1.58 to 4.09]—MSM vs Female) and a recent prior history of STI testing (aOR 5.65[4.30 to 7.43] ‘clinic tested’ vs ‘No’ recent testing history).

Conclusions

Subsequent clinic attendance amongst online STI test service users with negative test results was infrequent, suggesting that their needs were being met without placing an additional burden on clinic based services. However, unequal use of online services by different patient groups suggests that optimised messaging and the development of online services in partnership with users are required to improve uptake.