bluuebunny/crossref_metadata_2025 huggingface dataset:
Two-step tumor-targeting therapy via integrating metabolic lipid-engineering with in situ click chemistry
Authors: Lu Guihong , Zuo Liping , Zhang Jinfeng , Zhu Houshun , Zhuang Wanru , Wei Wei , Xie Hai-Yan
Published: February 2020

A highly efficient two-step targeting strategy integrating metabolic lipid-engineering with in situ click chemistry is developed, thus significantly improved the tumor theranostic performance of the red blood cells ghosts based drug delivery.
How many cells are enough for single-cell infrared spectroscopy?
Authors: Wang Yadi , Dai Wentao , Wang Yue , Liu Jixiang , Liu Zhixiao , Li Yuanyuan , Li Xueling , Hu Jun , Lü Junhong
Published: February 2020

The similarity distance among single-cell infrared spectra reveals that at least 15 cells are required to achieve robust results with 95% confidence.
Carbon and carbon composites obtained using deep eutectic solvents and aqueous dilutions thereof
Authors: Carrasco-Huertas Gaspar , Jiménez-Riobóo Rafael J. , Gutiérrez María Concepción , Ferrer María Luisa , del Monte Francisco
Published: February 2020

Extending the “all-in-one” features of DESs to DES/H2O binary mixtures.
Highly efficient and selective photocatalytic CO2 to CO conversion in aqueous solution
Authors: Chai Xiaomin , Huang Hai-Hua , Liu Huiping , Ke Zhuofeng , Yong Wen-Wen , Zhang Ming-Tian , Cheng Yuan-Sheng , Wei Xian-Wen , Zhang Liyan , Yuan Guozan
Published: February 2020

A Co-based complex displayed the highest photocatalytic performance for CO2 to CO conversion in aqueous media.
Hydration structure and water exchange kinetics at xenotime–water interfaces: implications for rare earth minerals separation
Authors: Roy Santanu , Wu Lili , Goverapet Srinivasan Sriram , Stack Andrew G. , Navrotsky Alexandra , Bryantsev Vyacheslav S.
Published: February 2020

Multilayering of water molecules at the xenotime–water interface and heterogeneous water exchange timescales between these layers obtained by computing 2D-free energy landscapes and employing Marcus theory of solvent exchange.
Water dynamics at electrified graphene interfaces: a jump model perspective
Authors: Zhang Yiwei , Stirnemann Guillaume , Hynes James T. , Laage Damien
Published: February 2020

Changes in water reorientation dynamics at electrified graphene interfaces arise from the interfaces’ impact on water hydrogen-bond exchanges; the asymmetric behavior with electrode potential sign is quantitatively described by an extended jump model.
Cation vacancy related crystal structure and bandgap and their effects on the thermoelectric performance of Cu-ternary systems Cu3+δIn5Te9 (δ = 0–0.175)
Authors: Li Min , Xia Yafen , Luo Yong , Zhong Yaqiong , Cui Jiaolin
Published: February 2020

The fundamental impact of the crystal distortion (CD) on the lattice part (κL) has been revealed in the Cu3In5Te9-based ternary system.
Synergistic photocatalysis–Fenton reaction for selective conversion of methane to methanol at room temperature
Authors: Zeng Yi , Liu Hang Chen , Wang Jing Sheng , Wu Xing Yang , Wang Song Ling
Published: February 2020

Combining the photocatalysis and Fenton reaction highly promote the yield and selectivity of CH3OH from CH4 with solar light at room temperature, up to 471 μmol g−1 h−1 and 83%, respectively.
Zeolitic imidazolate framework-8 coated Fe3O4@SiO2 composites for magnetic solid-phase extraction of bisphenols
Authors: Liu Jinfei , Qiu Huijiao , Zhang Fei , Li Yan
Published: February 2020

A new magnetic composite material ZIF-8 coated Fe3O4@SiO2 was employed for preconcentration and detection of trace BPs in water and plastic products.
Structural evolution of large Fe3O4microspheres on graphene oxide for efficient conversion of syngas into α-olefins
Authors: Yang Pengju , Jiang Feng , Liu Bing , Xu Yuebing , Liu Xiaohao
Published: February 2020

Large porous Fe3O4microspheres on graphene oxide under FTS reaction conditions can evolve into much smaller iron carbide nanocapsules, which show excellent and stable activity and high α-olefin productivity.
Screening and characterisation of CdTe/CdS quantum dot-binding peptides for material surface functionalisation
Authors: Suwatthanarak Thanawat , Tanaka Masayoshi , Minamide Taisuke , Harvie Andrew J. , Tamang Abiral , Critchley Kevin , Evans Stephen D. , Okochi Mina
Published: February 2020

We explored peptide binders to quantum dots (QDs) and proposed a simple and bio-friendly QD functionalisation using dual-functional peptides.
Aqueous aging of a silica coated TiO2 UV filter used in sunscreens: investigations at the molecular scale with dynamic nuclear polarization NMR
Authors: Slomberg Danielle L. , Catalano Riccardo , Ziarelli Fabio , Viel Stéphane , Bartolomei Vincent , Labille Jérôme , Masion Armand
Published: February 2020

Short-term, aqueous aging of a commercial nanocomposite TiO2 UV filter with a protective SiO2 shell was examined in abiotic simulated fresh- and seawater.
One-pot synthesis of corolla-shaped gold nanostructures with (110) planes
Authors: Xu Xiaochuan , Zhang Haipeng , Liu Bin , Yang Jianhui
Published: February 2020

The corolla-shaped gold nanostructures with (110) planes were synthesized using ethylenediaminetetraacetic acid and polyvinylpyrrolidone as the co-reductants and shape-directing agents.
Continuous flow synthesis of phase transition-resistant titania microparticles with tunable morphologies
Authors: Campbell Zachary S. , Jackson Daniel , Lustik Jacob , Al-Rashdi Amur K. , Bennett Jeffrey A. , Li Fanxing , Abolhasani Milad
Published: February 2020

A flow chemistry strategy for synthesis of anatase titania microparticles utilizing a flow-focusing microreactor integrated with a collimated UV LED is presented. The synthesized microparticles possess a wide variety of morphologies and high surface areas (up to 362 m2 g−1).
Fibrous testing papers for fluorescence trace sensing and photodynamic destruction of antibiotic-resistant bacteria
Authors: Zhao Long , Liu Yuan , Zhang Zhanlin , Wei Jiaojun , Xie Songzhi , Li Xiaohong
Published: February 2020

The increasing prevalence of antibiotic-resistant bacteria needs rapid identification and efficient destruction routes.
Organic/inorganic nanohybrids rejuvenate photodynamic cancer therapy
Authors: Liang Chen , Zhang Xinglin , Wang Zhichao , Wang Wenjun , Yang Mengsu , Dong Xiaochen
Published: February 2020

This article reviewed the organic/inorganic hybrid nanoplatforms for improving the photodynamic therapeutic efficacy of cancers.
Advances and challenges in metallic nanomaterial synthesis and antibacterial applications
Authors: Guo Zengchao , Chen Yun , Wang Yihan , Jiang Hui , Wang Xuemei
Published: February 2020

Schematic diagram of the antibacterial mechanism of metal nanoparticles.
Smart diagnostic nano-agents for cerebral ischemia
Authors: Tapeinos Christos , Battaglini Matteo , Marino Attilio , Ciofani Gianni
Published: February 2020

A summary of the latest developments on imaging techniques and smart nano-diagnostics used for ischemic stroke.
S,N-Codoped oil-soluble fluorescent carbon dots for a high color-rendering WLED
Authors: Wang Quan , Gao Yixun , Wang Boyang , Guo Yuanyuan , Ahmad Umar , Wang Yanqing , Wang Yao , Lu Siyu , Li Hao , Zhou Guofu
Published: February 2020

Novel S,N-codoped hydrophobic carbon dots (S,N-OCDs) were directly fabricated into a white light-emitting-diode (WLED), which showed excellent color rendering properties.
A controlled growth of triangular AuCu alloy nanostars and high photocatalytic activities of AuCu@CdS heterostars
Authors: Liu Qi-Yu , Zhong Yao , Jiang Zheng-Zhi , Chen Kai , Ma Song , Wang Peng-Fei , Wang Wei , Zhou Li , Luoshan Meng-Dai , Wang Qu-Quan
Published: February 2020

Metallic nanostars have tunable plasmon resonances and high photocatalytic activities; however, controlling the number and length uniformity of branches for the colloidal nanostars is still a challenge.
Spontaneously chiral cubic liquid crystal: three interpenetrating networks with a twist
Authors: Zeng Xiangbing , Ungar Goran
Published: February 2020

The spontaneously chiral bicontinuous cubic phase consists of three interpenetrating networks, where molecules stack with a twist forming network segments.
The Effects of Deep Brain Stimulation on Speech Intelligibility in Persons With Essential Tremor
Authors: Sandström Linda , Blomstedt Patric , Karlsson Fredrik , Hartelius Lena
Published: February 2020

Purpose

The aim of this study was to investigate how deep brain stimulation (DBS) of the caudal zona incerta (cZi) affects speech intelligibility in persons with essential tremor.

Method

Thirty-five participants were evaluated: off stimulation, on chronic stimulation optimized to alleviate tremor, and during unilateral stimulation at increasing amplitude levels. At each stimulation condition, the participants read 10 unique nonsense sentences from the Swedish Test of Intelligibility. Two listeners, blinded to stimulation condition, transcribed all recorded sentences orthographically in a randomized procedure. A mean speech intelligibility score for each patient and stimulation condition was computed, and comparisons were made between scores off and on stimulation.

Results

Chronic cZi-DBS had no significant effect on speech intelligibility, and there was no difference in outcome between bilateral and unilateral treatments. During unilateral stimulation at increasing amplitudes, nine participants demonstrated deteriorating speech intelligibility. These nine participants were on average older and had more superior contacts activated during the evaluation compared with the participants without deterioration.

Conclusions

Chronic cZi-DBS, optimized for tremor suppression, does not generally affect speech intelligibility in persons with essential tremor. Furthermore, speech intelligibility may be preserved in many individuals, even when stimulated at high amplitudes. Adverse effects of high-amplitude unilateral stimulation observed in this study were associated with stimulation originating from a more superior location, as well as with the participants' age. These results, highlighting age and stimulation location as contributing to speech intelligibility outcomes, were, however, based on a limited number of individuals experiencing adverse effects with high-amplitude stimulation and should, therefore, be interpreted with caution.
Improved Conversation Outcomes After Social Communication Skills Training for People With Traumatic Brain Injury and Their Communication Partners: A Clinical Trial Investigating In-Person and Telehealth Delivery
Authors: Rietdijk Rachael , Power Emma , Attard Michelle , Heard Robert , Togher Leanne
Published: February 2020

Purpose

The aim of the study was to investigate the effectiveness of social communication skills training (TBIconneCT) for people with traumatic brain injury (TBI) and their communication partners, delivered in-person or via telehealth, on quality of conversations.

Method

This study is a clinical trial, including an in-person intervention group (
n =
17), a telehealth intervention group (
n =
19), and a historical control group (
n =
15). Participants were adults at least 6 months post moderate-to-severe TBI with social communication skills deficits and their usual communication partners. Participants completed a casual and purposeful conversation task at pre-intervention, postintervention, and a follow-up assessment. A blinded assessor evaluated conversations using the Adapted Measure of Participation in Conversation and the Adapted Measure of Support in Conversation. Treatment effects were examined by comparing groups on change in ratings between pre- and posttraining. Maintenance of effects was examined using change between posttraining and follow-up assessment. The trial protocol was registered with the Australian New Zealand Clinical Trials Registry (ACTRN12615001024538).

Results

Trained participants with TBI had significant improvements in participation in casual conversation compared to controls. Trained communication partners also had significant improvements compared to controls on ratings of support in casual conversations. However, treatment effects were not maintained at follow-up for two of eight measures. Comparisons between outcomes of in-person and telehealth groups found negligible to small effect sizes for six of eight measures.

Conclusions

The findings reinforce previous studies demonstrating the efficacy of communication partner training after TBI. Telehealth delivery produced similar outcomes to in-person delivery.
Do Infants With Down Syndrome Show an Early Receptive Language Advantage?
Authors: Mason-Apps Emily , Stojanovik Vesna , Houston-Price Carmel , Seager Emily , Buckley Sue
Published: February 2020

Purpose

The study explored longitudinally the course of vocabulary and general language development in a group of infants with Down syndrome (DS) compared to a group of typically developing (TD) infants matched on nonverbal mental ability (NVMA).

Method

We compared the vocabulary and general language trajectories of the two groups in two ways: (a) at three time points during a 12-month period and (b) at two time points when the groups had made equal progress in NVMA (a period of 6 months for the TD infants vs. 12 months for the infants with DS).

Results

The TD group had overtaken the DS group on all general language and vocabulary measures by the end of the 12-month period. However, expressive communication and expressive vocabulary were developing at the same rate and level in the two groups when examined over a period in which the two groups were matched in gains in NVMA. Furthermore, the infants with DS showed a receptive language advantage over the TD group; this group's auditory comprehension and receptive vocabulary scores were superior to those of the TD group at both time points when NVMA was accounted for.

Conclusion

The results shed light on the widely reported discrepancy between expressive and receptive language in individuals with DS. Although infants with DS appear to be developing language skills more slowly than chronological age TD peers, when NVMA is taken into account, infants with DS do not have expressive language delays, and they seem to show a receptive language advantage.
The Nonverbal Processing of Actions Is an Area of Relative Strength in the Semantic Variant of Primary Progressive Aphasia
Authors: Auclair-Ouellet Noémie , Fossard Marion , Macoir Joël , Laforce Robert
Published: February 2020

Purpose

Better performance for actions compared to objects has been reported in the semantic variant of primary progressive aphasia (svPPA). This study investigated the influence of the assessment task (naming, semantic picture matching) over the dissociation between objects and actions.

Method

Ten individuals with svPPA and 17 matched controls completed object and action naming tests, and object and action semantic picture matching tests. Performance was compared between the svPPA and control groups, within the svPPA group, and for each participant with svPPA versus the control group individually.

Results

Compared to controls, participants with svPPA were impaired on object and action naming, and object and action semantic picture matching. As a group, participants with svPPA had an advantage for actions over objects and for semantic picture matching tests over naming tests. Eight participants had a better performance for actions compared to objects in naming, with three showing a significant difference. Nine participants had a better performance for actions compared to objects in semantic picture matching, with six showing a significant difference. For objects, semantic picture matching was better than naming in nine participants, with five showing a significant difference. For actions, semantic picture matching was better than naming in all 10 participants, with nine showing a significant difference.

Conclusion

The nonverbal processing of actions, as assessed with a semantic picture matching test, is an area of relative strength in svPPA. Clinical implications for assessment planning and interpretation and theoretical implications for current models of semantic cognition are discussed.
Auditory Feedback Control Mechanisms Do Not Contribute to Cortical Hyperactivity Within the Voice Production Network in Adductor Spasmodic Dysphonia
Authors: Daliri Ayoub , Heller Murray Elizabeth S. , Blood Anne J. , Burns James , Noordzij J. Pieter , Nieto-Castanon Alfonso , Tourville Jason A. , Guenther Frank H.
Published: February 2020

Purpose

Adductor spasmodic dysphonia (ADSD), the most common form of spasmodic dysphonia, is a debilitating voice disorder characterized by hyperactivity and muscle spasms in the vocal folds during speech. Prior neuroimaging studies have noted excessive brain activity during speech in participants with ADSD compared to controls. Speech involves an auditory feedback control mechanism that generates motor commands aimed at eliminating disparities between desired and actual auditory signals. Thus, excessive neural activity in ADSD during speech may reflect, at least in part, increased engagement of the auditory feedback control mechanism as it attempts to correct vocal production errors detected through audition.

Method

To test this possibility, functional magnetic resonance imaging was used to identify differences between participants with ADSD (
n
= 12) and age-matched controls (
n
= 12) in (a) brain activity when producing speech under different auditory feedback conditions and (b) resting-state functional connectivity within the cortical network responsible for vocalization.

Results

As seen in prior studies, the ADSD group had significantly higher activity than the control group during speech with normal auditory feedback (compared to a silent baseline task) in three left-hemisphere cortical regions: ventral Rolandic (sensorimotor) cortex, anterior planum temporale, and posterior superior temporal gyrus/planum temporale. Importantly, this same pattern of hyperactivity was also found when auditory feedback control of speech was eliminated through masking noise. Furthermore, the ADSD group had significantly higher resting-state functional connectivity between sensorimotor and auditory cortical regions within the left hemisphere as well as between the left and right hemispheres.

Conclusions

Together, our results indicate that hyperactivation in the cortical speech network of individuals with ADSD does not result from hyperactive auditory feedback control mechanisms and rather is likely related to impairments in somatosensory feedback control and/or feedforward control mechanisms.
VLT/X-shooter spectroscopy of massive young stellar objects in the 30 Doradus region of the Large Magellanic Cloud
Authors: van Gelder M. L. , Kaper L. , Japelj J. , Ramírez-Tannus M. C. , Ellerbroek L. E. , Barbá R. H. , Bestenlehner J. M. , Bik A. , Gräfener G. , de Koter A. , de Mink S. E. , Sabbi E. , Sana H. , Sewiło M. , Vink J. S. , Walborn N. R.
Published: February 2020

The process of massive star (M ≥ 8 M⊙) formation is still poorly understood. Observations of massive young stellar objects (MYSOs) are challenging due to their rarity, short formation timescale, large distances, and high circumstellar extinction. Here, we present the results of a spectroscopic analysis of a population of MYSOs in the Large Magellanic Cloud. We took advantage of the spectral resolution and wavelength coverage of X-shooter (300−2500 nm), which is mounted on the European Southern Observatory Very Large Telescope, to detect characteristic spectral features in a dozen MYSO candidates near 30 Doradus, the largest starburst region in the Local Group hosting the most massive stars known. The X-shooter spectra are strongly contaminated by nebular emission. We used a scaling method to subtract the nebular contamination from our objects. We detect Hα, β, [O I] 630.0 nm, Ca II, infrared triplet [Fe II] 1643.5 nm, fluorescent Fe II1687.8 nm, H22121.8 nm, Brγ, and CO bandhead emission in the spectra of multiple candidates. This leads to the spectroscopic confirmation of ten candidates as bona fide MYSOs. We compared our observations with photometric observations from the literature and find all MYSOs to have a strong near-infrared excess. We computed lower limits to the brightness and luminosity of the MYSO candidates, confirming the near-infrared excess and the massive nature of the objects. No clear correlation is seen between the Brγluminosity and metallicity. Combining our sample with other LMC samples results in a combined detection rate of disk features, such as fluorescent Fe IIand CO bandheads, which is consistent with the Galactic rate (40%). Most of our MYSOs show outflow features.
Correlational analyses of the relationships between altitude and carapace size of Ostracoda (Crustacea)
Authors: Dalgakıran Enes , Külköylüoğlu Okan , Yavuzatmaca Mehmet , Akdemir Derya
Published: February 2020

To explore the relationship between ostracods carapace (body) size and altitude, 117 non-marine aquatic habitats were sampled from Mersin province (Turkey) during 03–09 October 2015. A total of 36 species and 14 sub-fossils were detected from 66 of 117 sites located between −3 m and 1630 m a.s.l. Thirty-four of the species are previously unknown in the province. In addition, four of the taxa were new records for the Turkish Ostracoda fauna. Five species (Ilyocypris bradyi, Heterocypris salina, H. incongruens, Psychrodromus olivaceus, Potamocypris fallax) were the most common among all habitats with relatively wide ecological and altitudinal ranges. Canonical correspondence analyses revealed 72.6% of the relationship between 12 ostracods and five environmental variables. Water temperature and pH were the two most influential variables (p < 0.05) on the species. The mean length of right and left valves of the species were significantly different (p < 0.01, N  =  3980) at all altitudinal ranges. A strong tendency of changes in valve height with increasing altitude seems to be more prominent (p < 0.05) than the changes in length for some species. Our results do not support some ecological rules but rather, suggest that a linear relationship between carapace size and altitude may only be applicable for some ostracods.
Personalized Life Cycle Assessment – Reflecting Individuality within the Methodological Framework
Authors: Briem Ann-Kathrin , Betten Thomas , Wehner Daniel
Published: February 2020

Growing environmental awareness in society increasingly influences individual everyday decisions, such as which product to buy or how to sustainably use it. Yet, available information to support these decisions is often limited, or difficult to understand particularly regarding sustainability. Effective ways of communicating environmental impacts of individual decisions are required to close this gap. While Life Cycle Assessment (LCA) is an established tool to evaluate environmental impacts of products and services and support environmental decision-making, the results are typically standardized and based on statistical or averaged data. However, for individuals, this information might be irrelevant, as it neglects personal situation, behavior, information need, or individual level of expertise. In tackling those central issues of personalization in LCA, this article focuses on two main questions: How can individual aspects be addressed in LCA and at which stages of the methodology can LCA be personalized? For this purpose, the ISO 14040/44 standards are analyzed regarding individuality, and current approaches in literature are presented. In an explorative approach, this research identifies two general approaches of personalizing LCA. A personalized Life Cycle Inventory (LCI) enables evaluating the environmental impacts of personal(ized) products and conditions. A broader personalization approach based on the flexibility of the methodological framework of LCA aims at providing understandable and relevant results for individual stakeholders. This article provides an overview, outlines key aspects of this vision, and points out further research needs to bring the concept into application.
Die Misere der konservativen Adipositastherapie in Deutschland: Bestandsaufnahme und Lösungsvorschlag
Authors: Luley Claus
Published: February 2020

Etwa neun Millionen Deutsche leiden an einer behandlungsbedürftigen Adipositas und verursachen durch Folgekrankheiten jährliche Kosten von 63 Milliarden Euro. Die wirksame bariatrische Chirurgie kann nicht in allen Fällen eingesetzt werden, und den konservativen multimodalen Maßnahmen mangelt es vor allem an Wirksamkeit und Verfügbarkeit. Zusätzliche Hürden sind die fehlende Einstufung der Adipositas als therapiebedürftige Erkrankung, das resultierende Fehlen von Kostenerstattungen der konservativen Adipositastherapie sowie restriktive Vorgaben in Leitlinien zu Prävention und Therapie. Größtes Problem ist das Misverhältnis zwischen Patientenanzahl und Anzahl der Therapieeinrichtungen, da jeder Schwerpunktpraxis ca. 12000 Patienten gegenüberstehen.

Einen Ausweg bietet die telemedizinische Gewichtsreduktion mittels internetbasiertem Telemonitoring und Telecoaching von Ernährung und Bewegung. Diese umfassend evaluierte Maßnahme erwies sich nicht nur als wirksam, sondern als besonders kosten- und zeiteffizient. Jüngere Daten zeigen eine unverminderte Wirksamkeit, wenn die bisher einmalige Patientenschulung vor Ort durch eine Konferenzschulung per Internet ersetzt wurde. Damit kann die Maßnahme überregional durchgeführt werden. So können auch große Patientenzahlen durch wenige Zentren versorgt werden, wobei deren Spezialisierung die Kosteneffizienz weiter steigern wird.

Der Lösungsvorschlag besteht demnach aus einer dreiteiligen Stufentherapie. Die erste Stufe bildet die überregionale, telemedizinische Basistherapie durch wenige Zentren pro Bundesland. Bei ungenügendem Ergebnis erfolgt als zweite Stufe die Überweisung in interdisziplinäre Schwerpunktpraxen. Die bariatrische Chirurgie bildet schließlich die dritte Stufe. Die Kosten für die telemedizinische Basistherapie können durch Medikamenteneinsparung bei Typ-2-Diabetikern kompensiert werden, wie eine kontrollierte und randomisierte Studie nachwies.
Renale Osteodystrophie
Authors: Lehmann Gabriele , Pfeil Alexander , Oelzner Peter , Wolf Gunter
Published: February 2020

Chronische Nierenerkrankungen weisen eine zunehmende Inzidenz und Prävalenz auf und verursachen Komplikationen an verschiedenen Organsystemen. Die Veränderungen des Mineralstoffwechsels bei chronischer Niereninsuffizienz bedingen Störungen des kardiovaskulären Systems und des Knochenstoffwechsels mit den klinischen Endpunkten Myokardinfarkt/Schlaganfall und Fraktur und münden in eine gesteigerte Mortalität. Die renale Osteodystrophie ist ein Teil der CKD-MBD. Der Terminus „renale Osteodystrophie“ ist den histologischen Knochengewebsveränderungen vorbehalten und erfordert zur Charakterisierung eine Knochenbiopsie. Die internationale Klassifizierung unterscheidet 4 Formen: sekundärer Hyperparathyreoidismus, Osteomalazie, gemischte urämische Osteodystrophie und adyname renale Knochenerkrankung. Die nicht invasiven Untersuchungen entsprechen denen, die zur Diagnostik der Osteoporose eingesetzt werden. Das Spektrum der therapeutischen Optionen ist begrenzt.
A Case of Hemophagocytic Lymphohistiocytosis following Refractory
Kawasaki Disease
Authors: Li Ye , Wang Yulong , Li Shen , Liu Mingjing , Wang Dingding , Xu Chaoyue , Zhang Luan
Published: February 2020

Introduction

Hemophagocytic lymphohistiocytosis (HLH) is a systemic inflammatory disorder
characterized by uncontrolled histiocytic proliferation, hemophagocytosis,
macrophage activation, and up-regulation of inflammatory cytokines (Grom AA.,
Current opinion in rheumatology 2003; 15: 587–590). HLH is usually divided
into two types: primary (familial) HLH and secondary (reactive) HLH. Primary HLH is
associated with primary immune deficiencies in which specific gene mutations play an
important role, such as perforin defects.
Melaleuca alternifolia Essential Oil: Evaluation of Skin Permeation and Distribution from Topical Formulations with a Solvent-Free Analytical Method
Authors: Capetti Francesca , Sgorbini Barbara , Cagliero Cecilia , Argenziano Monica , Cavalli Roberta , Milano Luisella , Bicchi Carlo , Rubiolo Patrizia
Published: February 2020

Melaleuca alternifolia essential oil (tea tree oil) is widely used as an ingredient in skin care products because of its recognized biological activities. The European Scientific Committee on Consumer Products constantly promotes research and collection of data on both skin distribution and systemic exposure to tea tree oil components after the application of topical formulations. This study quantitatively evaluates permeation, skin layer distribution (stratum corneum, epidermis, and dermis), and release into the surrounding environment of bioactive tea tree oil markers (i.e., α-pinene, β-pinene, α-terpinene, 1,8-cineole, γ-terpinene, 4-terpineol, α-terpineol) when a 5% tea tree oil formulation is applied at a finite dosing regimen. Permeation kinetics were studied in vitro on pig ear skin using conventional static glass Franz diffusion cells and cells ad hoc modified to monitor the release of markers into the atmosphere. Formulation, receiving phases, and skin layers were analyzed using a fully automatic and solvent-free method based on headspace solid-phase microextraction/gas chromatography-mass spectrometry. This approach affords, for the first time, to quantify tea tree oil markers in the different skin layers while avoiding using solvents and overcoming the existing methods based on solvent extraction. The skin layers contained less than 1% of each tea tree oil marker in total. Only oxygenated terpenes significantly permeated across the skin, while hydrocarbons were only absorbed at trace level. Substantial amounts of markers were released into the atmosphere.
Kommentar von Luise Tavera: Ein halbes Jahrhundert voller Motivation
Authors: Tavera Luise
Published: February 2020

„Ein zukunftsfähiges Gesundheitssystem aus Sicht der jungen Generation“ – ist das Thema der Vorsitzenden der Denkschmiede Gesundheit, Luise Tavera. Auch auf der 38. Bundesfachtagung der femak am 16. und 17. März 2020 in Rotenburg a. d. Fulda, wo sie als Referentin eingeladen ist.
Strategische Krankenhauslogistik: Logistikstrategie 2025 im Krankenhaus
Authors: Kriegel Johannes
Published: February 2020

Für das Krankenhaus als Angebotsplattform und Knotenpunkt im vernetzten Gesundheitswesen gewinnt eine übergreifende und konzeptionelle Logistik zusehends an Bedeutung. Entscheidungsverantwortliche im Krankenhaus müssen es schaffen, mittels eines zukunftsorientierten Krankenhauslogistikkonzepts, die unterschiedlichen Akteure und Aktivitäten in der Krankenhausversorgung von morgen miteinander zu verbinden.
Interview Mit Benedikt Bumm: „Wer keine Digitalisierungsstrategie hat, läuft Gefahr, langfristig abgehängt zu werden.“
Authors: Kempe Lisa
Published: February 2020

Die drei Klinik-Einkaufsgemeinschaften P.E.G. eG, Prospitalia GmbH und Sana Einkauf & Logistik GmbH haben gemeinsam ein Tool für die Verwaltung elektronischer Artikelstammdaten entwickelt. Mit dem Ergebnis – dem Healthcare Content Data Portal (HCDP) – sind die drei 2019 an den Start gegangen.
Apps im Klinikeinkauf: Der Einkauf muss sich rasch weiterentwickeln
Authors: Krojer Stefan
Published: February 2020

Apps kennt man hauptsächlich aus dem privaten Bereich: Sie sind nützlich, praktisch und benutzerfreundlich. Meistens verbindet man mit dem Begriff „Apps“ mobile, native Apps auf dem Handy. Die meisten Apps gibt es aber auch als „Web-App”, also als Browser-Lösung. Auch im Klinikeinkauf könnten einige Apps Nutzen stiften.
Managing interrelated tensions in headquarters–subsidiary relationships: The case of a multinational hybrid organization
Authors: Ambos Tina C , Fuchs Sebastian H , Zimmermann Alexander
Published: February 2020

While all multinational organizations face the challenge of managing tensions between local integration and global responsiveness, they are increasingly required to pursue additional, often paradoxical, objectives – such as social and commercial goals. However, we know little about how these tensions at the core of the MNC strategy interact. Based on an inductive qualitative study of four headquarters–subsidiary relationships in a Latin American Multinational Hybrid Organization, we develop a model showing the interplay of multiple tensions and management approaches to address them. This allows us to contribute to research on subsidiary roles, which we found to differ depending on how multiple tensions are addressed. Furthermore, we add to the literature on hybridity in multinational organizations by pointing out how regional differences between units of a single organization unfold. Finally, we provide some practical recommendations for the management of multinational hybrid organizations.
Different combinations of sodium monensin and virginiamycin during feedlot finishing of Nellore cattle
Authors: Rigueiro A. L. N. , Pereira M. C. S. , Squizatti M. M. , Ferreira M. M. , Dondé S. C. , Luiz F. P. , Silvestre A. M. , Muller L. R. , Garcia C. P. , Bueno A. P. D. , Toledo L. V. , Estevam D. D. , Martins C. L. , Arrigoni M. D. B. , Millen D. D.
Published: February 2020

Context
The use of two feed additives, to maximise rumen fermentation, in finishing diets offered to feedlot cattle may positively impact performance.

Aims
This study, conducted at the São Paulo State University feedlot, Botucatu campus, Brazil, was designed to evaluate the effects of the combined use of monensin (MON; 30 mg/kg of dry matter; (DM)) and virginiamycin (VM; 25 mg/kg of DM) in high-concentrate diets during the adaptation and finishing periods on feedlot performance, carcass traits, feeding behaviour, blood gas profile, rumen morphometrics and apparent total tract digestibility of nutrients of Nellore cattle.

Methods
The experiment was designed as a completely randomised block, replicated six times (3 bulls/pen), in which 72 20 months of age yearling Nellore bulls (388.0 ± 31.1 kg) were fed in 24 pens for 90 days according to the treatments: (1) MON during the entire feeding period (T1), (2) MON + VM during adaptation and only VM during the finishing period (T2), (3) MON + VM during the entire feeding period (T3), and (4) VM during the adaptation and MON + VM during the finishing period (T4). The adaptation program consisted of ad libitum feeding of three diets over the adaptation period of 19 days with concentrate level increasing from 69% to 84% of diet DM.

Key results
Overall, bulls fed on T2 had a greater DM intake (P < 0.01), final bodyweight (P = 0.04), average daily gain (P = 0.03), hot carcass weight (P < 0.01), final Longissimus muscle area (P = 0.05), Longissimus muscle area daily gain (P = 0.01), improved carcass G:F (P < 0.01) and increased dressing percentage (P < 0.01). Similarly, bulls fed on T2 were faster to consume 1 kg of either DM (P < 0.01) or neutral detergent fibre (P < 0.01) after 60 days on feed. Furthermore, bulls fed on T2 presented a greater (P = 0.05) cell proliferation index in the rumen papillae.

Conclusions
According to the results, Nellore yearling bulls should be fed high-concentrate diets containing MON and VM during adaptation, and only VM during the finishing period to improve overall feedlot performance.

Implications
The use of both MON and VM proved to be helpful only during the adaptation period.
Iodine analysis of foodstuffs samples using epithermal instrumental neutron activation analysis
Authors: Sutisna  , Yusuf S , Suprapti S
Published: February 2020

Iodine is an essential element that has an important role in the proper growth and thyroid hormone functioning of humans. Iodine deficiency was correlated with the health status of human-caused by malnutrition. The analytical method to analyze the Iodine content on foodstuffs is limited because Iodine concentration exists in a level of a trace. 127I has a ratio of I
0 to s relatively high, and it is possible to obtain 128I (t1/2 = 24.5 minutes) using nuclear reaction with an epithermal neutron. Samples were collected at Magelang region, and it consists of foodstuffs that consumed by the citizen. All sample has been dried using Freeze dryer at-90 °C and 0.03 bar for 24-48 hours. After drying, the sample then pounded to get the form of granules smooth, about 100-150 mesh. About 40 to 130 mg of sample was weighed accurately on a clean micro vial of Polyethylene. Irradiation has been carried out at l5 MW reactor power using neutron epithermal for 45 seconds at the rabbit facility of GA. Siwabessy reactor. After cooling 5 to 10 minutes, the irradiated sample then counted for 300 seconds, and the gamma-ray spectra obtained emitted have been analyzed by Hyperlab software. Several standard reference materials of NIST have been used as analytical quality control. The experimental result shows that the Iodine has the Boron ratio, RB, and the Advantage factor, Fadv, equal to 2.4 and 21, respectively. Trace element of Iodine has been determined quantitatively on nine spices, seven types of meat, and 32 vegetables. The Iodine concentration on spices have average 1.57 ± 0.23 mg/kg with range value 0.38 mg/kg to 3.4 mg/kg. Iodine on vegetable have average of 2.00 ± 0.43 mg/kg with range value of 0.38 mg/kg to 7.30 mg/kg. Meanwhile, its concentration on meat has range 0.71 mg/kg to 2.16 mg/kg, with an average of 1.44 ± 0.28 mg/kg, lower than that on vegetables. Epithermal INAA is a reliable analytical technique for Iodine determination quantitatively.
Design of Sorting Machine Prototype in Electronic Circuit Based on NI-MyRIO 1900
Authors: Kurniawati Nisa , Abimanyu Adi , Muhtadan
Published: February 2020

Nowadays, the laboratory at STTN-BATAN prepares and returns components to the storage area manually, where this has the disadvantage of the possibility of making a significant mistake. Therefore, a prototype of a sorting machine is made that can sort electronic components automatically on the conveyor. The sorting machine is made with the 1900 NI-myRIO controller. Components that pass above the conveyor are taken. Images from components will then be processed by means of color pattern matching which will compare the image of the component with the template that has been stored in the program. The object in this study is a resistor component that is above a PCB, with a large resistor that is different. The PCB that has been compared with the template will be passed from the conveyor for a certain time and then driven by a servo motor to the storage area with a separator block. In addition, the type of resistor and the amount will be read and displayed on the user’s computer. From the test results, it was found that the accuracy of the sorting machine was 91% with precision being 93%.
Synthesis and characterization of zeolite-g-polyacrylamide (Zeolite-g-PAAM) by using simultaneous irradiation technique
Authors: Puspitasari T , Darwis D , Pangerteni D S , Oktaviani O , Sari M P
Published: February 2020

In this study, we synthesized the adsorbent based zeolite as an adsorbent for toxic metal removal. The modified zeolite adsorbent has been successfully synthesized using polymerization radiation technique by gamma rays. The monomer of acrylamide was applied to be grafted onto zeolite. The irradiation doses used in this study were 10–75 kGy and we obtained the optimum dose for synthesizing the zeolite-g-polyacrylamide by using the simultaneous irradiation technique was 25 kGy, with 99.88% and 48.01% for the gel fraction and degree of grafting, respectively. The zeolite-g-polyacrylamide were characterized by Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), Differential Thermal Analysis (DTA) and Scanning Electron Microscope (SEM).
Effectiveness of Reducing Cyanide Levels in The Dioscorea hispida Dennst Bulbs Through Soaking in Seawater and Interaction with Ash scrub
Authors: Harimu L , Haeruddin  , Baari M J , Sutapa I W
Published: February 2020

The high concentration of cyanide in Dioscorea hispida dennst should be reduced through immersion in seawater and interaction with rubbing ash. Soaking seawater prepared in immersion time 12, 24, and 36 hours accompanied by the replacement of seawater every three hours, while interaction with rubbing ash was ready with 75% and 100% concentration of ash on 12, 24, and 36 hours of storage time respectively. Measurement of cyanide concentrations of Dioscorea hispida dennst samples was prepared by argentometry titration with Liebig method after through the steam distillation process. Based on the results of this study, it found that immersion time for 12, 24, and 36 hours could reduce cyanide concentrations about 48.30%, 64.44%, and 70.88%, respectively. The interaction by using 75% rubbing ash for 12, 24, and 36 hours, it can reduce 24.09%, 38.69%, and 51.42% cyanide concentration in Dioscorea hispida dennst tubers, respectively. The Dioscorea hispida dennst tubers smeared with100% rubbing ash for 12, 24, and 36 hours. It can reduce cyanide content in Dioscorea hispida dennst by 36.26%, 49.92%, and 59.63%, respectively. Further treatment with drying and fermentation produces Dioscorea hispida dennst with a lower concentration of cyanide about 88.68% with a soft and white texture.
Drinfeld-type presentations of loop algebras
Authors: Chen Fulin , Jing Naihuan , Kong Fei , Tan Shaobin
Published: February 2020

Let

g

\mathfrak {g}

be the derived subalgebra of a Kac-Moody Lie algebra of finite-type or affine-type, let

μ
\mu

be a diagram automorphism of

g

\mathfrak {g}

, and let

L

(

g

,
μ
)

\mathcal {L}(\mathfrak {g},\mu )

be the loop algebra of

g

\mathfrak {g}

associated to

μ
\mu

. In this paper, by using the vertex algebra technique, we provide a general construction of current-type presentations for the universal central extension

g

^

[
μ
]

\widehat {\mathfrak {g}}[\mu ]

of

L

(

g

,
μ
)

\mathcal {L}(\mathfrak {g},\mu )

. The construction contains the classical limit of Drinfeld’s new realization for (twisted and untwisted) quantum affine algebras [Soviet Math. Dokl. 36 (1988), pp. 212–216] and the Moody-Rao-Yokonuma presentation for toroidal Lie algebras [Geom. Dedicata 35 (1990), pp. 283–307] as special examples. As an application, when

g

\mathfrak {g}

is of simply-laced-type, we prove that the classical limit of the

μ
\mu

-twisted quantum affinization of the quantum Kac-Moody algebra associated to

g

\mathfrak {g}

introduced in [J. Math. Phys. 59 (2018), 081701] is the universal enveloping algebra of

g

^

[
μ
]

\widehat {\mathfrak {g}}[\mu ]

.
A flow method for the dual Orlicz–Minkowski problem
Authors: Liu YanNan , Lu Jian
Published: February 2020

In this paper the dual Orlicz–Minkowski problem, a generalization of the

L
p

L_p

dual Minkowski problem, is studied. By studying a flow involving the Gauss curvature and support function, we obtain a new existence result of solutions to this problem for smooth measures.
The shapes of Galois quartic fields
Authors: H Piper , Harron Robert
Published: February 2020

We determine the shapes of all degree

4
4

number fields that are Galois. These lie in four infinite families depending on the Galois group and the tame versus wild ramification of the field. In the

V
4

V_4

case, each family is a two-dimensional space of orthorhombic lattices and we show that the shapes are equidistributed, in a regularized sense, in these spaces as the discriminant goes to infinity (with respect to natural measures). We also show that the shape is a complete invariant in some natural families of

V
4

V_4

-quartic fields. For

C
4

C_4

-quartic fields, each family is a one-dimensional space of tetragonal lattices and the shapes make up a discrete subset of points in these spaces. We prove asymptotics for the number of fields with a given shape in this case.
Groping Toward Perversion: From Queer Methods to Queer States in Recent Queer Criticism
Authors: Bascom Ben
Published: February 2020

What’s so queer about the nineteenth century? According to three recent studies of American literature—Elizabeth Freeman’s Beside You in Time (2019), Natasha Hurley’s Circulating Queerness (2018), and Benjamin Kahan’s The Book of Minor Perverts (2019)—the answer may be fairly all encompassing. For these critics, queerness is both an orientation and an object of study, enlivening, engendering, and uncovering a plethora of inchoate possibilities for imagining nonnormativity in the long nineteenth century. As such, these studies help resituate the critical capacity for queer studies to engage with historical material while also attending to the ephemeral possibilities that queerness, as a heuristic, frames, from being a methodology, a narrative trope, or a marker of excess that gets overpassed through dominant and emergent ideologies. Bringing together novels, plays, performances, short stories, and life narratives—along with compelling debates in the fields of queer studies—these books are sure to motivate continued work on the intersections of queerness, affect, and the literary while also plotting ways to consider how queerness disrupts and confirms the biopolitics of sex as a category of analysis.
Mutational analysis indicates that abnormalities in rhizobial infection and subsequent plant cell and bacteroid differentiation in pea (Pisum sativum) nodules coincide with abnormal cytokinin responses and localization
Authors: Dolgikh Elena A , Kusakin Pyotr G , Kitaeva Anna B , Tsyganova Anna V , Kirienko Anna N , Leppyanen Irina V , Dolgikh Aleksandra V , Ilina Elena L , Demchenko Kirill N , Tikhonovich Igor A , Tsyganov Viktor E
Published: February 2020

Background and Aims

Recent findings indicate that Nod factor signalling is tightly interconnected with phytohormonal regulation that affects the development of nodules. Since the mechanisms of this interaction are still far from understood, here the distribution of cytokinin and auxin in pea (Pisum sativum) nodules was investigated. In addition, the effect of certain mutations blocking rhizobial infection and subsequent plant cell and bacteroid differentiation on cytokinin distribution in nodules was analysed.

Methods

Patterns of cytokinin and auxin in pea nodules were profiled using both responsive genetic constructs and antibodies.

Key Results

In wild-type nodules, cytokinins were found in the meristem, infection zone and apical part of the nitrogen fixation zone, whereas auxin localization was restricted to the meristem and peripheral tissues. We found significantly altered cytokinin distribution in sym33 and sym40 pea mutants defective in IPD3/CYCLOPS and EFD transcription factors, respectively. In the sym33 mutants impaired in bacterial accommodation and subsequent nodule differentiation, cytokinin localization was mostly limited to the meristem. In addition, we found significantly decreased expression of LOG1 and A-type RR11 as well as KNOX3 and NIN genes in the sym33 mutants, which correlated with low cellular cytokinin levels. In the sym40 mutant, cytokinins were detected in the nodule infection zone but, in contrast to the wild type, they were absent in infection droplets.

Conclusions

In conclusion, our findings suggest that enhanced cytokinin accumulation during the late stages of symbiosis development may be associated with bacterial penetration into the plant cells and subsequent plant cell and bacteroid differentiation.