bluuebunny/crossref_metadata_2025 huggingface dataset:
Der Zusammenhang von Regeleinhaltung und Lehrkraftfeedback mit der sozialen Akzeptanz von Grundschulkindern. Eine empirische Analyse unter Berücksichtigung von Schulkind-Dyaden
Authors: Spilles Markus , Huber Christian , Nicolay Philipp , König Johannes , Hennemann Thomas
Published: January 2023

Peer-Beziehungen gelten als ein Schlüsselfaktor für die kindliche Entwicklung. Internationale wie nationale Untersuchungen bestätigen, dass insbesondere Kinder mit externalisierenden Verhaltensproblemen schlechter sozial integriert sind als ihre Mitschülerinnen und Mitschüler. Darüber hinaus zeigen vereinzelte Feldstudien außerhalb von Deutschland, dass auch Lehrkraftfeedback die soziale Integration bedingt. Während bisherige Studien meist Verhaltensprobleme durch Lehrkraftbeurteilungen und Lehrkraftfeedback durch Verhaltensbeobachtungen erfassten, basieren die Auswertungen der aktuellen Publikation ausschließlich auf den gegenseitigen Einschätzungen von Schulkindern. Es werden vier Forschungsfragen betrachtet: 1. Gibt es einen Zusammenhang zwischen Regeleinhaltung und sozialer Akzeptanz? 2. Wird der Zusammenhang von Regeleinhaltung und sozialer Akzeptanz durch die Regeleinhaltung des urteilenden Kindes moderiert? 3. Gibt es einen Zusammenhang zwischen Lehrkraftfeedback und sozialer Akzeptanz? 4. Wird der Zusammenhang von Regeleinhaltung bzw. Lehrkraftfeedback und sozialer Akzeptanz durch die Klassenstufenzugehörigkeit moderiert? Analysiert werden Querschnittsdaten von n = 989 Kindern aus 50 zweiten, dritten und vierten Klassen in Nordrhein-Westfalen. Die statistische Auswertung erfolgt anhand einer logistischen Mehrebenen-Regressionsanalyse mit Random-Intercept-Modellen, wobei sowohl die Nestung in Schulklassen als auch die kreuzweise Nestung in insgesamt 17.409 Schulkind-Dyaden Berücksichtigung findet. Die Ergebnisse bestätigen, dass die soziale Akzeptanz eines Kindes sowohl mit der Regeleinhaltung als auch mit dem Lehrkraftfeedback zusammenhängt. Darüber hinaus neigen Schulkinder, die sich selbst gut an die Klassenregeln halten, dazu, auch solche Mitschülerinnen und Mitschüler zu wählen, bei denen sie ebenfalls eine hohe Regelkonformität einschätzen. Der Zusammenhang zwischen sozialer Akzeptanz und Regeleinhaltung bzw. Lehrkraftfeedback scheint sich im Laufe der Jahrgangsstufen zu steigern.
Boys’ motivation profiles in mathematics: relations with contextual factors, wellbeing and engagement in a boys-only school
Authors: Beswick Kim , Watt Helen M. G. , Granziera Helena , Geiger Vince , Fraser Sharon
Published: January 2023

This study examined the extent to which boys fell into clusters comprised of different levels of motivations and costs. In turn, the antecedents of these clusters and associations with engagement and wellbeing outcomes were considered. Based on survey responses from 168 students across Years 5, 7 and 9 from an all-boys' school in Sydney, Australia, three clusters were identified: Positively Engaged, Disengaged, and Struggling Ambitious. Performance-approach and avoidance achievement goals, mastery classroom goal structure, perceived peer valuing of mathematics and teacher enthusiasm differentially predicted profile membership. Clusters were also found to differ in terms of both wellbeing and engagement, such that students within maladaptive profiles evidenced the most negative outcomes. The study reaffirms prior work, holds implications for addressing student motivation in mathematics, and adds to understanding of the interplay of individual and classroom goal structures in relation to students’ mathematics expectancies, values and resultant outcomes.
Surgery Matters: Progress in Surgical Management of Gastric Cancer
Authors: Beyer Katharina
Published: January 2023

Opinion statement

The surgical treatment of gastric carcinoma has progressed significantly in the past few decades. A major milestone was the establishment of multimodal therapies for locally advanced tumours. Improvements in the technique of endoscopic resection have supplanted surgery in the early stages of many cases of gastric cancer. In cases in which an endoscopic resection is not possible, surgical limited resection procedures for the early stages of carcinoma are an equal alternative to gastrectomy in the field of oncology. Proximal gastrectomy is extensively discussed in this context. Whether proximal gastrectomy leads to a better quality of life and better nutritional well-being than total gastrectomy depends on the reconstruction chosen. The outcome cannot be conclusively assessed at present. For locally advanced stages, total or subtotal gastrectomy with D2 lymphadenectomy is now the global standard. A subtotal gastrectomy requires sufficiently long tumour-free proximal resection margins. Recent data indicate that proximal margins of at least 3 cm for tumours with an expansive growth pattern and at least 5 cm for those with an infiltrative growth pattern are sufficient. The most frequently performed reconstruction worldwide following gastrectomy is the Roux-en-Y reconstruction. However, there is evidence that pouch reconstruction is superior in terms of quality of life and nutritional well-being. Oncological gastric surgery is increasingly being performed laparoscopically. The safety and oncological equivalency were first demonstrated for early carcinomas and then for locally advanced tumours, by cohort studies and RCTs. Some studies suggest that laparoscopic procedures may be advantageous in early postoperative recovery. Robotic gastrectomy is also increasing in use. Preliminary results suggest that robotic gastrectomy may have added value in lymphadenectomy and in the early postoperative course. However, further studies are needed to substantiate these results. There is an ongoing debate about the best treatment option for gastric cancer with oligometastatic disease. Preliminary results indicate that certain patient groups could benefit from resection of the primary tumour and metastases following chemotherapy. However, the exact conditions in which patients may benefit have yet to be confirmed by ongoing trials.
Management of Fatigue in Patients with Advanced Cancer
Authors: Stone Patrick , Candelmi Diego Ezequiel , Kandola Kerran , Montero Ligia , Smetham Dom , Suleman Sahil , Fernando Asanga , Rojí Rocío
Published: January 2023

Opinion statement

Fatigue is a common and distressing symptom experienced by patients with cancer. It is most common in patients with locally advanced or metastatic incurable disease. It can have profound effects on quality-of-life and physical functioning. In addition to general supportive measures (directed at tackling contributory conditions and comorbidities), a variety of specific interventions have been developed which can be broadly categorised as physical therapies, psychological therapies or medication. There is some evidence that each of these approaches can have benefits in patients with earlier stage disease, those undergoing active treatment and in cancer survivors. The best evidence is for aerobic exercise, yoga, cognitive-behavioural therapy (CBT) and psycho-educational interventions. Less strong evidence supports the use of medications such as methylphenidate or ginseng. In patients with advanced disease, it is likely that the mechanisms of fatigue or the factors contributing to fatigue maintenance may be different. Relatively fewer studies have been undertaken in this group and the evidence is correspondingly weaker. The authors recommend the cautious use of aerobic exercise (e.g. walking) in those who are still mobile. The authors advise considering the use of psycho-educational approaches or CBT in those patients who are able to engage in such forms of therapy. In patients near the end-of-life, the authors advise use of dexamethasone (short-term use) and other pharmacological treatments only on the basis of a clinical trial.
Gene Modulation with CRISPR-based Tools in Human iPSC-Cardiomyocytes
Authors: Han Julie Leann , Entcheva Emilia
Published: January 2023

Precise control of gene expression (knock-out, knock-in, knockdown or overexpression) is at the heart of functional genomics – an approach to dissect the contribution of a gene/protein to the system’s function. The development of a human in vitro system that can be patient-specific, induced pluripotent stem cells, iPSC, and the ability to obtain various cell types of interest, have empowered human disease modeling and therapeutic development. Scalable tools have been deployed for gene modulation in these cells and derivatives, including pharmacological means, DNA-based RNA interference and standard RNA interference (shRNA/siRNA). The CRISPR/Cas9 gene editing system, borrowed from bacteria and adopted for use in mammalian cells a decade ago, offers cell-specific genetic targeting and versatility. Outside genome editing, more subtle, time-resolved gene modulation is possible by using a catalytically “dead” Cas9 enzyme linked to an effector of gene transcription in combination with a guide RNA. The CRISPRi / CRISPRa (interference/activation) system evolved over the last decade as a scalable technology for performing functional genomics with libraries of gRNAs. Here, we review key developments of these approaches and their deployment in cardiovascular research. We discuss specific use with iPSC-cardiomyocytes and the challenges in further translation of these techniques.

Graphical Abstract
Visfatin induces ovarian cancer resistance to anoikis by regulating mitochondrial activity
Authors: Gogola-Mruk Justyna , Tworzydło Wacław , Krawczyk Kinga , Marynowicz Weronika , Ptak Anna
Published: January 2023

Purpose

Ovarian cancer is characterized by recurrent peritoneal and distant metastasis. To survive in a non-adherent state, floating ovarian cancer spheroids develop mechanisms to resist anoikis. Moreover, ascitic fluid from ovarian cancer patients contains high levels of visfatin with anti-apoptotic properties. However, the mechanism by which visfatin induces anoikis resistance in ovarian cancer spheroids remains unknown. Here, we aimed to assess wheather visfatin which possess anti-apoptotic properties can induce resistance of anoikis in ovarian cancer spheroids.

Methods

Visfatin synthesis were examined using a commercial human visfatin ELISA Kit. Spheroid were exposed to visfatin and cell viability and caspase 3/7 activity were measured using CellTiter-Glo 3D cell viability assay and Caspase-Glo® 3/7 Assay System. mRNA and protein expression were analyzed by Real-time PCR and Western Blot analysis, respectively. Analysis of mitochondrial activity was estimated by JC-1 staining.

Results

First, our results suggested higher expression and secretion of visfatin by epithelial than by granulosa ovarian cells, and in non-cancer tissues versus cancer tissues. Interestingly, visfatin increased the proliferation/apoptosis ratio in ovarian cancer spheroids. Specifically, both the intrinsic and extrinsic pathways of anoikis were regulated by visfatin. Moreover, the effect of the visfatin inhibitor (FK866) was opposite to that of visfatin. Furthermore, both NAMPT and FK866 affected mitochondrial activity in ovarian cancer cells.

Conclusion

In conclusion, visfatin acts as an anti-apoptotic factor by regulating mitochondrial activity, leading to anoikis resistance in ovarian cancer spheroids. The finding suggest visfatin as a potential novel therapeutic target for the treatment of ovarian carcinoma with peritoneal dissemination.
TOP2A Expression in Pheochromocytoma and Abdominal Paraganglioma: a Marker of Poor Clinical Outcome?
Authors: Solhusløkk Höse Karolina , Stenman Adam , Svahn Fredrika , Larsson Catharina , Juhlin C. Christofer
Published: January 2023

Pheochromocytoma and abdominal paraganglioma (PPGL) are rare neuroendocrine tumors originating from chromaffin cells. Even though only 10–15% of the tumors metastasize, all PPGLs are considered potentially malignant. Topoisomerase 2A (TOP2A) is a protein involved in cell proliferation and has been found to be over-expressed in metastatic PPGL. To provide support whether TOP2A could serve as a prognostic marker, 88 PPGLs (of which 8 metastatic/relapsing) and 10 normal adrenal gland samples were assessed for TOP2A mRNA expression using quantitative real-time PCR (qRT-PCR) and TOP2A immunohistochemistry. Comparisons to clinical parameters connected to metastatic behavior were made, and The Cancer Genome Atlas was used for validation of the results. A significant association between high TOP2A mRNA expression in primary PPGL and subsequent metastatic events (p = 0.008) was found, as well as to specific histological features and clinical parameters connected to metastatic behavior and mutations in SDHB. TOP2A immunoreactivity was calculated as an index of positive nuclei divided by the total amount of nuclei, and this index associated with TOP2A mRNA levels (p = 0.023) as well as the Ki-67 labeling index (p = 0.001). To conclude, TOP2A is a potential prognostic marker as it is frequently elevated in PPGL displaying subsequent metastatic disease, and future studies in larger cohorts are warranted to determine if a TOP2A index as assessed by immunohistochemistry could be a marker of poor outcome. Additionally, elevated levels of TOP2A could indicate a potential actionable event, and future studies with topoisomerase inhibitors would be of interest.
Effect of scan-time shortening on the 11C-PHNO binding potential to dopamine D3 receptor in humans and test–retest reliability
Authors: Matsunaga Keiko , Tonomura Misato , Abe Kohji , Shimosegawa Eku
Published: January 2023

Objective

11C-PHNO is a PET radioligand most specific to dopamine D3 receptor (D3R). The long scan duration of 120 min used in quantification of 11C-PHNO binding to D3R in previous studies is challenging to subjects. The main objective of this study was to investigate the effects of shorter scan times on the binding of 11C-PHNO to D3R and test–retest reliability using the latest digital whole-body PET system.

Methods

Two 120-min 11C-PHNO brain scans were performed in 7 healthy subjects using a digital whole-body PET/CT. The binding potential relative to non-displaceable tracer in the tissue (BPND) of D3R-rich regions: the pallidum, ventral striatum (VST), substantia nigra (SN) and hypothalamus, were quantified using the simplified reference tissue model. The bias, correlation, and test–retest reliability of BPND, which includes the test–retest variability (TRV) and intraclass correlation coefficient (ICC), were evaluated and compared between scans of shorter durations (40–110 min post-injection) and the original 120-min scan acquisitions.

Results

Progressively, shorter scan durations were associated with underestimation of BPND, slightly decreased correlation with 120-min derived BPND, and decrease in test–retest reliability. The BPND values of the pallidum, VST and SN from the shortened 90-min scans showed excellent correlation with those derived from the 120-min scans (determination coefficients > 0.98), and the bias within 5%. The test–retest reliability of BPND in these regions derived from 90-min scan (TRV of 3% in the VST and pallidum, 7% in the SN and the ICC exceeded 0.88) was comparable to those obtained in previous 120-min studies using brain-dedicated PET scanners. In the hypothalamus, the BPND values obtained from scan-time less than 110 min showed bias larger than 5% and the TRV more than 9%.

Conclusion

The scan-time shortening causes bias and decreasing test–retest reliability of 11C-PHNO BPND. However, in the whole-body PET system, 90-min scan duration was sufficient for estimating the 11C-PHNO BPND in the D3R-rich striatum and SN with small bias and at the test–retest reliability comparable to those derived from 120-min scans using the brain-dedicated PET systems.
Phylogenetic, Developmental and Functional Aspects of Stomatal Patterning: Lessons from Magnoliids
Authors: Rudall Paula J.
Published: January 2023

The magnoliid clade encompasses 18 extant families arranged in four orders, plus several extinct taxa, including some of the most ancient angiosperm fossils. The clade is characterized by paracytic stomata with a distinct pair of lateral subsidiary cells that flank the guard cells, though other stomatal types are also reported, including anomocytic and anisocytic. In contrast with monocots, the paracytic stomata of magnoliids develop from linear triads, and the lateral subsidiary cells are stomatal-lineage ground cells (SLGCs). Anisocytic stomata typically possess three SLGCs. Amplifying divisions are rare in magnoliids, but occur in some Piperales, in association with anisocytic stomata. Differences in mature stomatal types result from differences in cell shape and polarity at critical developmental stages. Stomatal clusters have been reported in Cinnamomum (Lauraceae) and Galbulimima (Himantandraceae), but neither are apparently formed by amplifying divisions, in contrast with eudicots. In Galbulimima, each peltate scale hair is surrounded by a ring of 3–8 non-contiguous stomata, each derived from different initial meristemoids.
Implications of Post-recanalization Perfusion Deficit After Acute Ischemic Stroke: a Scoping Review of Clinical and Preclinical Imaging Studies
Authors: van der Knaap Noa , Franx Bart A. A. , Majoie Charles B. L. M. , van der Lugt Aad , Dijkhuizen Rick M. ,   on behalf of the CONTRAST consortium
Published: January 2023

The goal of reperfusion therapy for acute ischemic stroke (AIS) is to restore cerebral blood flow through recanalization of the occluded vessel. Unfortunately, successful recanalization does not always result in favorable clinical outcome. Post-recanalization perfusion deficits (PRPDs), constituted by cerebral hypo- or hyperperfusion, may contribute to lagging patient recovery rates, but its clinical significance remains unclear. This scoping review provides an overview of clinical and preclinical findings on post-ischemic reperfusion, aiming to elucidate the pattern and consequences of PRPD from a translational perspective. The MEDLINE database was searched for quantitative clinical and preclinical studies of AIS reporting PRPD based on cerebral circulation parameters acquired by translational tomographic imaging methods. PRPD and stroke outcome were mapped on a charting table, creating an overview of PRPD after AIS. Twenty-two clinical and twenty-two preclinical studies were included. Post-recanalization hypoperfusion is rarely reported in clinical studies (4/22) but unequivocally associated with detrimental outcome. Post-recanalization hyperperfusion is more commonly reported (18/22 clinical studies) and may be associated with positive or negative outcome. PRPD has been replicated in animal studies, offering mechanistic insights into causes and consequences of PRPD and allowing delineation of possible courses of PRPD. Complex relationships exist between PRPD and stroke outcome. Diversity in methods and lack of standardized definitions in reperfusion studies complicate the characterization of reperfusion patterns. Recommendations are made to advance the understanding of PRPD mechanisms and to further disentangle the relation between PRPD and disease outcome.
When Do We Start Caring About Insect Welfare?
Authors: Klobučar Tina , Fisher David N.
Published: January 2023

The world is facing an incoming global protein shortage due to existing malnutrition and further rapid increases in population size. It will however be difficult to greatly expand traditional methods of protein production such as cattle, chicken and pig farming, due to space limitations and environmental costs such as deforestation. As a result, alternative sources of protein that require less space and fewer resources, such as insects and other invertebrates, are being sought. The Neotropics are a key area of focus given the widespread prevalence of entomophagy and developing animal welfare regulations. Unlike vertebrate livestock however, insect “minilivestock” are typically not protected by existing animal welfare regulations. This is despite the fact that the evidence is mounting that insects possess “personalities”, may experience affective states analogous to emotions and feel something like pain. In this forum article, we highlight this discrepancy, outline some of the emerging research on the topic and identify areas for future research. There are various empirical and ethical questions that must be addressed urgently while insect farming is ramped up around the globe. Finally, we describe the benefits and also potential costs of regulation for insect welfare.
Development of double-sided friction stir welding of advanced high strength steel sheets
Authors: Matsushita Muneo , Yamagishi Daiki , Igi Satoshi , Ikeda Rinsei
Published: January 2023

Double-sided friction stir welding (FSW), performed with a pair of rotation tools, was studied in an attempt to increase the joining speed when applied to welding of automotive advanced high-strength steels (AHSS). The experiments were performed on butt joint of 1.6-mm-thick 1180 MPa grade steel sheets, and sound welds were obtained when the travel speed was no more than 4 m/min, fairly comparable with laser beam welding (LBW), one of the conventional automotive welding processes. It was clarified by experimental and numerical analyses that the enhancement in travel speed was due to the unique material flow interactively developed by a pair of rotation tools. Double-sided FSW was performed at 3 m/min of joining speed on butt joint of dissimilar steel sheets in a combination of 1.5 GPa and 590 MPa grades. The mechanical properties of the welded joints were evaluated by tensile, V-bending and Erichsen tests comparing with LBW, which verified that double-sided FSW exhibited sufficient mechanical properties for the press-forming to produce automotive parts. A prototype automotive part was successfully fabricated using the tailor-welded blank welded with double-sided FSW, which demonstrates its applicability to automotive production.
The effects of non-andrological medications on erectile dysfunction: a large single-center retrospective study
Authors: Mazzilli R. , Zamponi V. , Mangini F. , Olana S. , Defeudis G. , Faggiano A. , Gianfrilli D.
Published: January 2023

Purpose

To evaluate the association among andrological diseases at the first outpatient visit and the medications taken by patients for other comorbidities, as well as the differential impact between specific medication and relative comorbidities.

Methods

This is a single-center retrospective study based on subjects who referred to the Andrology Unit with a well-defined andrological diagnosis.

Results

A total of 3752 subjects were studied (mean age ± DS 46.2 ± 16.5 years). A total of 19 categories of andrological diseases and 110 type of medications for other comorbidities were identified. ED was the most frequent andrological pathology at the first andrological examination (28.7%), followed by infertility (12.4%). The couple of variables that were statistically significant in the univariate association analysis (p < 0.001) were: ED and (a) antihypertensives; (b) antihyperglycemics; (c) lipids-lowering; (d) psychotropics. The univariate and multivariate regression analyses confirmed the association. All the related comorbidities were also significantly associated with the univariate analysis, and all remained significantly associated with multivariate analysis. A multivariate analysis was also conducted to analyze the association between ED and the following pairs of variables “DM-antihyperglycemics”, “dyslipidemia-lipids-lowering”, and “hypertension-antihypertensives”. In all cases, the pathology, but not the specific treatment, was significantly associated with ED.

Conclusion

ED is significantly associated with antihypertensive, antihyperglycemic, lipid-lowering, psychotropic drugs’ intake. Anyway, ED appears to be more related to the diseases than to the specific therapies. The definitive cause/effect relationship should be established based on future prospective studies.
Pandemic Shift: Virtual Self-Care Courses for Caregivers of Veterans
Authors: Martindale-Adams Jennifer , Stark Deanna , Zuber Jeffrey , Scariano Linda , Green April , Nichols Linda O.
Published: January 2023

Self-care improves health and well-being, yet many caregivers neglect it. During COVID-19, self-care courses for caregivers of veterans transitioned from in-person to virtual videoconferencing. The format remained the same with caregiver groups and a trainer. This observational study examined in-person and virtual caregivers’ satisfaction with courses. Caregivers (1120 in-person, 962 virtual) could attend five courses before and following March 2020 transition to virtual. Evaluations (N = 1665) examined demographics, satisfaction, and utility. Characteristics were compared between in-person and virtual participants using chi-squared tests. Qualitative caregiver comments were compared. Half of the caregivers were over 60 years old; 49% had been caregivers at least 6 years. Caregivers were primarily women (91%) and spouses (75%), with more spouses virtually (p = 0.006) and more men in-person (p < 0.001). Both groups endorsed learning new information, planning to use it in caregiving and for themselves, increasing knowledge and skills, and having needs met. Caregiver comments revealed six types of benefits: new information, information review, positive effects, interaction, plans to act, and instructor qualities. Caregivers in virtual groups more often mentioned learning more information, being reminded of information, and planning to take further action; in-person caregivers more often mentioned interaction as a benefit. Caregivers were satisfied with and found benefit from in-person and virtual self-care courses. Although in-person courses allow for more social connection with others, virtual courses offer decreased travel costs for instructors and increased convenience and access for caregivers.
Digitalization and enterprise architecture management: a perspective on benefits and challenges
Authors: Möhring Michael , Keller Barbara , Schmidt Rainer , Sandkuhl Kurt , Zimmermann Alfred
Published: January 2023

Many companies digitally transform their business models, processes, and services. They have also been using Enterprise Architecture Management approaches for a long time to synchronize corporate strategy and information technology. Such digitalization projects bring different challenges for Enterprise Architecture Management. Without understanding and addressing them, Enterprise Architecture Management projects will fail or not deliver the expected value. Since existing research has not yet addressed these challenges, they were investigated based on a qualitative expert study with leading industry experts from Europe. Furthermore, potential benefits of digitalization projects for Enterprise Architecture Management were researched. Our results provide a theoretical framework consisting of five identified challenges, triggers and a number of benefits. Furthermore, we discuss in what ways digitalization and EAM is a promising topic for future research.
This Is Not Who We Are
Authors: Shore Zachary
Published: January 2023

What kind of country is America? Zachary Shore tackles this polarizing question by spotlighting some of the most morally muddled matters of WWII. Should Japanese Americans be moved from the west coast to prevent sabotage? Should the German people be made to starve as punishment for launching the war? Should America drop atomic bombs to break Japan's will to fight? Surprisingly, despite wartime anger, most Americans and key officials favored mercy over revenge, yet a minority managed to push their punitive policies through. After the war, by feeding the hungry, rebuilding Western Europe and Japan, and airlifting supplies to a blockaded Berlin, America strove to restore the country's humanity, transforming its image in the eyes of the world. A compelling story of the struggle over racism and revenge, This Is Not Who We Are asks crucial questions about the nation's most agonizing divides.
Work-Life Balance
Authors: Sirgy M. Joseph , Lee Dong-Jin
Published: January 2023

Based on a thorough review of the research on work-life balance, Sirgy and Lee identify a set of personal interventions that selected employees commonly use to increase their work-life balance and life satisfaction. Personal interventions of work-life balance involve five behavior-based strategies and four cognition-based strategies. The behavior-based strategies are engaging in multiple roles and domains, increasing role enrichment, engaging in behavior-based compensation, managing role conflict, and creating role balance. The cognition-based strategies are segmenting roles and domains, integrating roles and domains, engaging in value-based compensation, and applying whole-life perspective in decision-making. This volume provides HR managers and HR consultants with pedagogical material designed to help them develop in-house workshops, seminars, and curricula for their employees to improve their work-life balance by using the personal interventions described in the book.
Exploiting high-slip flow regimes to improve inference of glacier bed topography
Authors: Morin Alexi , Flowers Gwenn E. , Nolan Andrew , Brinkerhoff Douglas , Berthier Etienne
Published: January 2023

Theory and observation show that glacier-flow regimes characterized by high basal slip enhance the projection of topographic detail to the surface, motivating this investigation into the efficacy of using glacier surges to improve bed estimation. Here we adapt a Bayesian inversion scheme and apply it to real and synthetic data as a proof of concept. Synthetic tests show a reduction in mean RMSE between true and inferred beds by more than half, and an increase in the mean correlation coefficient of ~0.5, when data from slip- versus deformation-dominated regimes are used. Multi-epoch inversions, which partition slip- and deformation-dominated regimes, are shown to outperform inversions that average over these flow regimes thereby squandering information. Tests with real data from a surging glacier in Yukon, Canada, corroborate these results, while highlighting the challenges of limited or inconsistent data. With the growing torrent of satellite-based observations, fast-flow events such as glacier surges offer potential to improve bed estimation for some of the world's most dynamic glaciers.
Sturm–Liouville theory and decay parameter for quadratic markov branching processes
Authors: Chen Anyue , Chen Yong , Gao Wu-Jun , Wu Xiaohan
Published: January 2023

For a quadratic Markov branching process (QMBP), we show that the decay parameter is equal to the first eigenvalue of a Sturm–Liouville operator associated with the partial differential equation that the generating function of the transition probability satisfies. The proof is based on the spectral properties of the Sturm–Liouville operator. Both the upper and lower bounds of the decay parameter are given explicitly by means of a version of Hardy’s inequality. Two examples are provided to illustrate our results. The important quantity, the Hardy index, which is closely linked to the decay parameter of the QMBP, is deeply investigated and estimated.
Embedding Regression: Models for Context-Specific Description and Inference
Authors: RODRIGUEZ PEDRO L. , SPIRLING ARTHUR , STEWART BRANDON M.
Published: January 2023

Social scientists commonly seek to make statements about how word use varies over circumstances—including time, partisan identity, or some other document-level covariate. For example, researchers might wish to know how Republicans and Democrats diverge in their understanding of the term “immigration.” Building on the success of pretrained language models, we introduce the à la carte on text (conText) embedding regression model for this purpose. This fast and simple method produces valid vector representations of how words are used—and thus what words “mean”—in different contexts. We show that it outperforms slower, more complicated alternatives and works well even with very few documents. The model also allows for hypothesis testing and statements about statistical significance. We demonstrate that it can be used for a broad range of important tasks, including understanding US polarization, historical legislative development, and sentiment detection. We provide open-source software for fitting the model.
Do Political Elites Have Accurate Perceptions of Social Conditions?
Authors: Thal Adam
Published: January 2023

Politicians often oppose economic policies benefiting low-income Americans. However, the mechanisms behind this political inequality are unclear. I ask whether politicians oppose these policies, in part, because they underestimate how many of those they govern are struggling financially. I test this theory with an original survey of 1,265 state legislative candidates. Contrary to my expectations, I find that politicians tend to overestimate how many of those they govern are struggling financially. At the same time, there are some instances in which politicians—and Republicans in particular—do underestimate the level of financial hardship among those they govern. In an experiment, I randomly assign politicians to have their misperceptions corrected. The results suggest that politicians' policy preferences would be similar even if they had a more accurate understanding of reality. Overall, the findings suggest that politicians may frequently misperceive the state of reality in which those they govern live.
Insurance Pricing, Distortions, and Moral Hazard: Quasi-Experimental Evidence from Deposit Insurance
Authors: Shoukry George F.
Published: January 2023

Pricing is integral to insurance design, directly influencing firm behavior and moral hazard, though its effects are insufficiently understood. I study a quasi-experiment in which deposit insurance premiums were changed for U.S. banks with unequal timing, generating differentials between banks in both levels and risk-based “steepness” of premiums. I find evidence that differentials in premiums resulted in distortions, including regulatory arbitrage, but also provided strong incentives to curb moral hazard. I find that firms that faced stronger pricing incentives to become (or remain) safer were more likely to subsequently do so than similar firms that faced weaker pricing incentives.
Importance of Atmospheric Transport on Methanesulfonic Acid (MSA) Concentrations in the Arctic Ocean During Summer Under Global Warming
Authors: Jiang Bei , Xie Zhouqing , Chen Afeng , Yue Fange , Yu Xiawei , Wang Longquan , Gu Weihua , Wu Xudong , Chai Zhangyan , Jin Ruilin
Published: January 2023

The climatic effects of aerosols derived from dimethyl sulfide (DMS) (e.g., methanesulfonic acid [MSA]) have long been of concern, particularly in the rapidly warming Arctic Ocean. Melting sea ice and increase in primary productivity can result in increased DMS emissions and MSA. However, the processes affecting MSA are complex. In addition to local sources, atmospheric chemistry processes, deposition, long‐distance transport, and regional heterogeneities influence MSA. This study used aerosol samples from the Chinese Polar Research Expedition during the summer of 2010–2016 and divided them into the Chukchi Sea (CS), high Arctic Ocean (HAO), and sea near Greenland (NG) to study the factors that influence the changes in MSA. For CS, MSA concentrations were primarily influenced by long‐distance transport from the Bering Sea air mass. Moreover, owing to the North Atlantic Oscillation, an increase in the Bering Sea temperature and a decrease in rainfall during air mass transport led to a significant increase in the concentration of MSA in the CS in 2016. When the sea ice concentration was between 0.2 and 0.6, high solar radiation likely promoted MSA formation in the HAO. For NG, the sources, rainfall and atmospheric chemical processes influenced the variations in MSA. This study highlights the importance of MSA transport in the CS and sea ice for MSA in the HAO under global warming.
IFNγ signaling in cytotoxic T cells restricts anti-tumor responses by inhibiting the maintenance and diversity of intra-tumoral stem-like T cells
Authors: Mazet Julie M. , Mahale Jagdish N. , Tong Orion , Watson Robert A. , Lechuga‐Vieco Ana Victoria , Pirgova Gabriela , Lau Vivian W. C. , Attar Moustafa , Koneva Lada A. , Sansom Stephen N. , Fairfax Benjamin P. , Gérard Audrey
Published: January 2023

IFNγ is an immune mediator with concomitant pro- and anti-tumor functions. Here, we provide evidence that IFNγ directly acts on intra-tumoral CD8 T cells to restrict anti-tumor responses. We report that expression of the IFNγ receptor β chain (IFNγR2) in CD8 T cells negatively correlates with clinical responsiveness to checkpoint blockade in metastatic melanoma patients, suggesting that the loss of sensitivity to IFNγ contributes to successful antitumor immunity. Indeed, specific deletion of IFNγR in CD8 T cells promotes tumor control in a mouse model of melanoma. Chronic IFNγ inhibits the maintenance, clonal diversity and proliferation of stem-like T cells. This leads to decreased generation of T cells with intermediate expression of exhaustion markers, previously associated with beneficial anti-tumor responses. This study provides evidence of a negative feedback loop whereby IFNγ depletes stem-like T cells to restrict anti-tumor immunity. Targeting this pathway might represent an alternative strategy to enhance T cell-based therapies.
A study on the changing trend and influencing factors of hospitalization costs of schizophrenia in economically underdeveloped areas of China
Authors: Li Jianjian , Du Hongmei , Dou Feng , Yang Chao , Zhao Yini , Ma Zhibin , Hu Xiaobin
Published: January 2023

The public health problems caused by schizophrenia are becoming increasingly prominent and can place a huge economic burden on society. This study takes Gansu Province as an example to analyze the level and changing trend of the economic burden of schizophrenia inpatients in economically underdeveloped areas of China. Using a multi-stage stratified cluster sampling method, 39,054 schizophrenics from 197 medical and health institutions in Gansu Province were selected as the research objects, and their medical expenses and related medical records were obtained from the medical information system. The rank sum test and Spearman rank correlation were used for univariate analysis. Quantile regression and random forest were used to analyze the influencing factors. The results show that the average length of stay of schizophrenics in Gansu Province of China was 52.01 days, and the average hospitalization cost was USD1653.96 from 2014 to 2019. During the six years, the average hospitalization costs per time decreased from USD2136.85 to USD1401.33. The average out-of-pocket costs per time decreased from USD1238.78 to USD267.68. And the average daily hospitalization costs increased from USD38.18 to USD41.25. The main factors influencing hospitalization costs are length of stay, proportion of medications, and schizophrenic subtype. The hospitalization costs per time of schizophrenics in Gansu Province have decreased but remain at a high level compared to some other chronic non-communicable diseases. In the future, attention should be paid to improving the efficiency of medical institutions, enhancing community management, and promoting the transformation of the management model of schizophrenia.
Structures of the sulfite detoxifying F420-dependent enzyme from Methanococcales
Authors: Jespersen Marion , Pierik Antonio J. , Wagner Tristan
Published: January 2023

Methanogenic archaea are main actors in the carbon cycle but are sensitive to reactive sulfite. Some methanogens use a sulfite detoxification system that combines an F420H2-oxidase with a sulfite reductase, both of which are proposed precursors of modern enzymes. Here, we present snapshots of this coupled system, named coenzyme F420-dependent sulfite reductase (Group I Fsr), obtained from two marine methanogens. Fsr organizes as a homotetramer, harboring an intertwined six-[4Fe–4S] cluster relay characterized by spectroscopy. The wire, spanning 5.4 nm, electronically connects the flavin to the siroheme center. Despite a structural architecture similar to dissimilatory sulfite reductases, Fsr shows a siroheme coordination and a reaction mechanism identical to assimilatory sulfite reductases. Accordingly, the reaction of Fsr is unidirectional, reducing sulfite or nitrite with F420H2. Our results provide structural insights into this unique fusion, in which a primitive sulfite reductase turns a poison into an elementary block of life.
Conductivity experiments for electrolyte formulations and their automated analysis
Authors: Rahmanian Fuzhan , Vogler Monika , Wölke Christian , Yan Peng , Fuchs Stefan , Winter Martin , Cekic-Laskovic Isidora , Stein Helge Sören
Published: January 2023

Electrolytes are considered crucial for the performance of batteries, and therefore indispensable for future energy storage research. This paper presents data that describes the effect of the electrolyte composition on the ionic conductivity. In particular, the data focuses on electrolytes composed of ethylene carbonate (EC), propylene carbonate (PC), ethyl methyl carbonate (EMC), and lithium hexafluorophosphate (LiPF6). The mass ratio of EC to PC was varied, while keeping the mass ratio of (EC + PC) and EMC at fixed values of 3:7 and 1:1. The conducting salt concentration was also varied during the study. Conductivity data was obtained from electrochemical impedance spectroscopy (EIS) measurements at various temperatures. Based on the thus obtained temperature series, the activation energy for ionic conduction was determined during the analysis. The data is presented here in a machine-readable format and includes a Python package for analyzing temperature series of electrolyte conductivity according to the Arrhenius equation and EIS data. The data may be useful e.g. for the training of machine learning models or for reference prior to experiments.
Chinese diabetes datasets for data-driven machine learning
Authors: Zhao Qinpei , Zhu Jinhao , Shen Xuan , Lin Chuwen , Zhang Yinjia , Liang Yuxiang , Cao Baige , Li Jiangfeng , Liu Xiang , Rao Weixiong , Wang Congrong
Published: January 2023

Data of the diabetes mellitus patients is essential in the study of diabetes management, especially when employing the data-driven machine learning methods into the management. To promote and facilitate the research in diabetes management, we have developed the ShanghaiT1DM and ShanghaiT2DM Datasets and made them publicly available for research purposes. This paper describes the datasets, which was acquired on Type 1 (n = 12) and Type 2 (n = 100) diabetic patients in Shanghai, China. The acquisition has been made in real-life conditions. The datasets contain the clinical characteristics, laboratory measurements and medications of the patients. Moreover, the continuous glucose monitoring readings with 3 to 14 days as a period together with the daily dietary information are also provided. The datasets can contribute to the development of data-driven algorithms/models and diabetes monitoring/managing technologies.
A new technique to study nutrient flow in host-parasite systems by carbon stable isotope analysis of amino acids and glucose
Authors: Hesse Tobias , Nachev Milen , Khaliq Shaista , Jochmann Maik A. , Franke Frederik , Scharsack Jörn P. , Kurtz Joachim , Sures Bernd , Schmidt Torsten C.
Published: January 2023

Stable isotope analysis of individual compounds is emerging as a powerful tool to study nutrient origin and conversion in host-parasite systems. We measured the carbon isotope composition of amino acids and glucose in the cestode Schistocephalus solidus and in liver and muscle tissues of its second intermediate host, the three-spined stickleback (Gasterosteus aculeatus), over the course of 90 days in a controlled infection experiment. Similar linear regressions of δ13C values over time and low trophic fractionation of essential amino acids indicate that the parasite assimilates nutrients from sources closely connected to the liver metabolism of its host. Biosynthesis of glucose in the parasite might occur from the glucogenic precursors alanine, asparagine and glutamine and with an isotope fractionation of − 2 to – 3 ‰ from enzymatic reactions, while trophic fractionation of glycine, serine and threonine could be interpreted as extensive nutrient conversion to fuel parasitic growth through one-carbon metabolism. Trophic fractionation of amino acids between sticklebacks and their diets was slightly increased in infected compared to uninfected individuals, which could be caused by increased (immune-) metabolic activities due to parasitic infection. Our results show that compound-specific stable isotope analysis has unique opportunities to study host and parasite physiology.
Light distribution in fat cell layers at physiological temperatures
Authors: Yanina Irina Yu. , Dyachenko Polina A. , Abdurashitov Arkady S. , Shalin Alexander S. , Minin Igor V. , Minin Oleg V. , Bulygin Andrey D. , Vrazhnov Denis A. , Kistenev Yury V. , Tuchin Valery V.
Published: January 2023

Adipose tissue (AT) optical properties for physiological temperatures and in vivo conditions are still insufficiently studied. The AT is composed mainly of packed cells close to spherical shape. It is a possible reason that AT demonstrates a very complicated spatial structure of reflected or transmitted light. It was shown with a cellular tissue phantom, is split into a fan of narrow tracks, originating from the insertion point and representing filament-like light distribution. The development of suitable approaches for describing light propagation in a AT is urgently needed. A mathematical model of the propagation of light through the layers of fat cells is proposed. It has been shown that the sharp local focusing of optical radiation (light localized near the shadow surface of the cells) and its cleavage by coupling whispering gallery modes depends on the optical thickness of the cell layer. The optical coherence tomography numerical simulation and experimental studies results demonstrate the importance of sharp local focusing in AT for understanding its optical properties for physiological conditions and at AT heating.
3D osteogenic differentiation of human iPSCs reveals the role of TGFβ signal in the transition from progenitors to osteoblasts and osteoblasts to osteocytes
Authors: Kawai Shunsuke , Sunaga Junko , Nagata Sanae , Nishio Megumi , Fukuda Masayuki , Kamakura Takeshi , Sun Liping , Jin Yonghui , Sakamoto Satoko , Watanabe Akira , Matsuda Shuichi , Adachi Taiji , Toguchida Junya
Published: January 2023

Although the formation of bone-like nodules is regarded as the differentiation process from stem cells to osteogenic cells, including osteoblasts and osteocytes, the precise biological events during nodule formation are unknown. Here we performed the osteogenic induction of human induced pluripotent stem cells using a three-dimensional (3D) culture system using type I collagen gel and a rapid induction method with retinoic acid. Confocal and time-lapse imaging revealed the osteogenic differentiation was initiated with vigorous focal proliferation followed by aggregation, from which cells invaded the gel. Invading cells changed their morphology and expressed osteocyte marker genes, suggesting the transition from osteoblasts to osteocytes. Single-cell RNA sequencing analysis revealed that 3D culture-induced cells with features of periosteal skeletal stem cells, some of which expressed TGFβ-regulated osteoblast-related molecules. The role of TGFβ signal was further analyzed in the transition from osteoblasts to osteocytes, which revealed that modulation of the TGFβ signal changed the morphology and motility of cells isolated from the 3D culture, suggesting that the TGFβ signal maintains the osteoblastic phenotype and the transition into osteocytes requires down-regulation of the TGFβ signal.