bluuebunny/crossref_metadata_2025 huggingface dataset:
A few FERPA training perspectives: Unexpected questions, Part 3
Authors: Rainsberger Richard
Published: October 2021

It's always a good experience for me after I have conducted a Family Educational Rights and Privacy Act workshop to hear questions from the audience about what is affecting their professional lives in their specific offices. The alumni director and the computer center director from last month's column had FERPA questions relating to their own professional responsibilities. I had answered the alumni director's questions and one of the computer center director's questions. That one related to having a student's name on the subject line of an email. He hadn't expected my complex answer. So before we discussed the next question, he and I sat down.
Most graduates do well 10 years later
Authors: Bannister Mary
Published: October 2021

“Baccalaureate and Beyond (B&B:08/18): First Look at the 2018 Employment and Educational Experiences of 2007–08 College Graduates,” a publication from the National Center for Education Statistics, reports employment, financial well‐being, and postbaccalaureate enrollment of 2007–2008 college graduates 10 years after earning bachelor's degrees. Results include:
High prevalence of extended‐spectrum beta‐lactamase organisms and the COVID‐19 pandemic impact on donor recruitment for fecal microbiota transplantation in Hong Kong
Authors: Yau Yuk Kam , Mak Wing Yan Joyce , Lui Nok Shun Rashid , Ng Wai Yin Rita , Cheung Choi Yan Kitty , Li Ying Lee Amy , Ching Yuet Ling Jessica , Chin Miu Ling , Lau Ho Shing Louis , Chan Ka Leung Francis , Chan Kay Sheung Paul , Ng Siew Chien
Published: October 2021

Background

With increasing number of clinical trials relating to fecal microbiota transplantation (FMT), it is crucial to identify and recruit long‐term, healthy, and regular fecal donors.

Objective

We aimed to report the outcomes of screening and recruitment of fecal donors for FMT.

Methods

Potential donors were recruited via advertisement through internal mass emails at a university. They were required to undergo a pre‐screening telephone interview, a detailed questionnaire, followed by blood and stool investigations.

Results

From January 2017 to December 2020, 119 potential donors were assessed with 75 failed pre‐screening. Reasons for failure included: inability to come back for regular and long‐term donation (n = 19), high body mass index (n = 17), underlying chronic illness or on long‐term medications (n = 11), being healthcare professionals (n = 10), use of antibiotics within 3 months (n = 5) and others (n = 13). Forty‐four donors completed questionnaires and 11 did not fulfill the clinical criteria. Of the remaining 33 potential donors who had stool and blood tests, 21 failed stool investigations (19 extended‐spectrum beta‐lactamase [ESBL] organisms, one Clostridioides difficile, one C. difficile plus Methicillin Resistant Staphylococcus aureus), one failed blood tests (high serum alkaline phosphatase level), one required long‐term medication and nine withdrew consent and/or lost to follow‐up. In total, only one out of 119 (0.8%) potential donors was successfully recruited as a regular donor.

Conclusion

There was a high failure rate in donor screening for FMT. Main reasons for screening failure included high prevalence of positive ESBL organisms in stool and failed commitment to regular stool donation.
Stereological and molecular studies on the effects of Ferula persica extract on wound healing in rats
Authors: Huang Lei , Wang Mengting , Ebrahimzadeh Mohammad Ali , Jafari Aref , Jiang Kejiao
Published: October 2021

Background

Ferula persica is one of the most important traditional medicinal plants that is used to treat various diseases such as diabetes, backache and rheumatism. The aim of the present study was to evaluate the anti‐inflammatory and wound healing potential of F. persica using stereological and molecular methods in experimental models.

Methods

In the present study, two wound models (circular excision and linear incision) were used. Male Wistar rats were divided into four groups (n = 16), including control, vehicle treated, treated with F. persica extract ointment (5% w/w) and treated with the reference drug (Madecassol). All the animals were treated topically once a day. The circular and linear wounds were treated for 9 and 17 days, respectively. At the end of the study, samples from wounds area were harvested for histology, stereology, immunohistochemistry and molecular assessments to determine the in vivo healing potential and anti‐inflammatory activity.

Results

We observed significant recovery in macroscopic evaluation of wound healing in the F. persica extract treated group compared with the control and vehicle treated groups (p < 0.05). Histological and stereological assessments showed complete repair of the epidermal layer, increasing fibroblast cells and collagen density, decreasing inflammatory cells and a remarkable degree of neovascularization by determining length density of blood vessels in the extract group, which were significant as compared to the control and vehicle treated groups (p < 0.05). Expressions of TNF‐α and TGF‐β were found to be decreased and increased (p > 0.05, p < 0.05, respectively), in the extract treated group as compared to the control and vehicle treated groups. Also, greater COX‐2 expression could be detected in the control and vehicle treated groups, which was significantly attenuated in the extract group.

Conclusion

Our results confirm that the F. persica extract is a valuable source of antioxidant and anti‐inflammatory activity and can allow damaged tissue in wounds to recover markedly.
Comparative pathology of dog and human prostate cancer
Authors: Ryman‐Tubb Toby , Lothion‐Roy Jennifer H. , Metzler Veronika M. , Harris Anna E. , Robinson Brian D. , Rizvanov Albert A. , Jeyapalan Jennie N. , James Victoria H. , England Gary , Rutland Catrin S. , Persson Jenny L. , Kenner Lukas , Rubin Mark A. , Mongan Nigel P. , de Brot Simone
Published: October 2021

Though relatively rare in dogs, prostate cancer (PCa) is the most common non‐cutaneous cancer in men. Human and canine prostate glands share many functional, anatomical and physiological features. Due to these similarities, canine PCa has been proposed as a model for PCa in men. PCa is typically androgen‐dependent at diagnosis in men and for this reason, androgen deprivation therapies (ADT) are important treatments for advanced PCa in men. In contrast, there is some evidence that PCa is diagnosed more commonly in castrate dogs, at which point, limited therapeutic options are available. In men, a major limitation of current ADT is that progression to a lethal and incurable form of PCa, termed castrate‐resistant prostate cancer (CRPC), is common. There is, therefore, an urgent need for a better understanding of the mechanism of PCa initiation and progression to CRPC to enable the development of novel therapeutic approaches. This review focuses on the functional, physiological, endocrine and histopathological similarities and differences in the prostate gland of these species. In particular, we focus on common physiological roles for androgen signalling in the prostate of men and dogs, we review the short‐ and longer‐term effects of castration on PCa incidence and progression in the dog and relate how this knowledge may be relevant to understanding the mechanisms of CRPC in men.
Using Long‐Term Data to Compare Two Sizes of Sherman Trap
Authors: Vanek John P. , Preuss Timothy S. , Rutter Andrew U. , Jones Holly P. , Glowacki Gary A.
Published: October 2021

Live traps are commonly used to inventory, monitor, and sample populations of small mammals. Due to the variety of available trap types, understanding differences between traps is important to minimize bias and plan future studies. Sherman traps (H. B. Sherman Trap, Inc., Tallahassee, FL, USA; hereafter Sherman traps) are a popular live trap that come in a variety of sizes. However, studies comparing the relative efficacy of different‐sized Sherman traps often focus on a single species or are limited by a lack of temporal and spatial replication, leading to contradictory or ambiguous results. Therefore, to better understand the relative efficacy of two commonly‐used sizes, we used a paired design and 10 years of trapping data to compare species richness, capture numbers, and mortality rates between small Sherman traps (5.1 × 6.4 × 16.5 cm) and large Sherman traps (7.6 × 8.9 × 22.9 cm) across 55 preserves in northeastern Illinois. Despite wide annual variation, we captured more small mammals in large traps except for the smallest taxa (Sorex spp.), the proportion of captures in large traps increased with body size, and large traps significantly reduced mortality rates for Peromyscus spp., meadow voles (Microtus pennsylvanicus), and short‐tailed shrews (Blarina brevicauda). We recommend the 7.6 × 8.9 × 22.9 cm Sherman trap for monitoring surveys in the midwestern USA when research or monitoring objectives include maximizing captures and species richness while minimizing mortality. However, we note the smaller‐sized trap may be useful to minimize bycatch when smaller species are being targeted. Finally, managers and biologists conducting short‐term or pilot studies should be wary of year effects, as we found substantial annual variation in relative capture rates between trap sizes. © 2021 The Wildlife Society.
The United Nations Basel Convention’s Global Plastic Waste Partnership: History, Evolution and Progress
Authors: Wingfield Susan , Lim Melisa
Published: October 2021

The pollution of our marine and terrestrial environment by plastic waste is one of the most pressing global environmental challenges faced today. Developing a circular plastic economy and limiting plastic pollution requires multilevel actions from different stakeholders including oil and petrochemical producers, plastic manufacturers, consumer goods companies, retailers, consumers, waste managers, waste management authorities, plastic recyclers and others. As well as cleaning up the enormous quantities of plastic waste already in our oceans and lakes, there is an urgent need to strengthen countries’ capacities to prevent, minimize and properly manage this waste. The Basel Convention, the most comprehensive global environmental treaty dealing with hazardous and other wastes, offers an important part of the solution. In addition to its provisions aimed at controlling the exports and imports of hazardous wastes and other wastes generated from households and ensuring their environmentally sound management, the Convention also seeks to tackle the problem at its source through prevention and minimization. With the addition of an amendment to the Convention specifically tackling plastic waste, and the establishment of a Plastic Waste Partnership, the Convention is positioned at the forefront in the fight against plastic pollution.
Microplastics in Terrestrial and Freshwater Environments
Authors: Kallenbach Emilie M. F. , Rødland Elisabeth S. , Buenaventura Nina T. , Hurley Rachel
Published: October 2021

In recent years, the focus of microplastic research has begun to observe a shift from the marine towards terrestrial and freshwater environments. This is in response to a greater awareness of the predominance of land-based sources in marine microplastic contamination. In this regard, terrestrial and freshwater environments are often perceived as conduits for microplastic particles to the oceans, but this overlooks substantial and important complexities associated with these systems, as well as the need to protect these ecosystems in their own right. This chapter focuses on several critical sources and pathways deemed to be highly important for the release of microplastics to the environment. These include road-associated microplastic particles (RAMP) and emissions related to agriculture that are, thus far, under-researched. Transfers and accumulations of particles within terrestrial and freshwater systems are also reviewed, including the state of knowledge on the occurrence of microplastics in different environmental compartments (air, water, sediments, biota). Methodological constraints are addressed, with particular focus on the need for greater harmonisation along all stages of sampling, analysis, and data handling. Finally, the chapter discusses the ultimate fate of particles released to terrestrial and freshwater environments and highlights critical research gaps that should be addressed to evolve our understanding of microplastic contamination in complex and dynamic environmental systems.
Weight of Evidence for the Microplastic Vector Effect in the Context of Chemical Risk Assessment
Authors: Koelmans Albert A. , Diepens Noël J. , Mohamed Nor Nur Hazimah
Published: October 2021

The concern that in nature, ingestion of microplastic (MP) increases exposure of organisms to plastic-associated chemicals (the ‘MP vector effect’) plays an important role in the current picture of the risks of microplastic for the environment and human health. An increasing number of studies on this topic have been conducted using a wide variety of approaches and techniques. At present, the MP vector effect is usually framed as ‘complex’, ‘under debate’ or ‘controversial’. Studies that critically discuss the approaches and techniques used to study the MP vector effect, and that provide suggestions for the harmonization needed to advance this debate, are scarce. Furthermore, only a few studies have strived at interpreting study outcomes in the light of environmentally relevant conditions. This constitutes a major research gap, because these are the conditions that are most relevant when informing risk assessment and management decisions. Based on a review of 61 publications, we propose evaluation criteria and guidance for MP vector studies and discuss current study designs using these criteria. The criteria are designed such that studies, which fulfil them, will be relevant to inform risk assessment. By critically reviewing the existing literature in the light of these criteria, a weight of evidence assessment is provided. We demonstrate that several studies did not meet the standards for their conclusions on the MP vector effect to stand, whereas others provided overwhelming evidence that the vector effect is unlikely to affect chemical risks under present natural conditions.
The Microplastic-Antibiotic Resistance Connection
Authors: Marathe Nachiket P. , Bank Michael S.
Published: October 2021

Microplastic pollution is a big and rapidly growing environmental problem. Although the direct effects of microplastic pollution are increasingly studied, the indirect effects are hardly investigated, especially in the context of spreading of disease and antibiotic resistance genes, posing an apparent hazard for human health. Microplastic particles provide a hydrophobic surface that provides substrate for attachment of microorganisms and readily supports formation of microbial biofilms. Pathogenic bacteria such as fish pathogens Aeromonas spp., Vibrio spp., and opportunistic human pathogens like Escherichia coli are present in these biofilms. Moreover, some of these pathogens are shown to be multidrug resistant. The presence of microplastics is known to enhance horizontal gene transfer in bacteria and thus, may contribute to dissemination of antibiotic resistance. Microplastics can also adsorb toxic chemicals like antibiotics and heavy metals, which are known to select for antibiotic resistance. Microplastics may, thus, serve as vectors for transport of pathogens and antibiotic resistance genes in the aquatic environment. In this book chapter, we provide background information on microplastic biofouling (“plastisphere concept”), discuss the relationship between microplastic and antibiotic resistance, and identify knowledge gaps and directions for future research.
An Operator Product Expansion for Form Factors II. Born level
Authors: Sever Amit , Tumanov Alexander G. , Wilhelm Matthias
Published: October 2021

Abstract

Form factors in planar $$ \mathcal{N} $$
N
= 4 Super-Yang-Mills theory admit a type of non-perturbative operator product expansion (OPE), as we have recently shown in [1]. This expansion is based on a decomposition of the dual periodic Wilson loop into elementary building blocks: the known pentagon transitions and a new object that we call form factor transition, which encodes the information about the local operator. In this paper, we compute the two-particle form factor transitions for the chiral part of the stress-tensor supermultiplet at Born level; they yield the leading contribution to the OPE. To achieve this, we explicitly construct the Gubser-Klebanov-Polyakov two-particle singlet states. The resulting transitions are then used to test the OPE against known perturbative data and to make higher-loop predictions.
Backreaction of Schwinger pair creation in massive QED2
Authors: Gold Gregory , McGady David A. , Patil Subodh P. , Vardanyan Valeri
Published: October 2021

Abstract

Particle-antiparticle pairs can be produced by background electric fields via the Schwinger mechanism provided they are unconfined. If, as in QED in (3+1)-d these particles are massive, the particle production rate is exponentially suppressed below a threshold field strength. Above this threshold, the energy for pair creation must come from the electric field itself which ought to eventually relax to the threshold strength. Calculating this relaxation in a self-consistent manner, however, is difficult. Chu and Vachaspati addressed this problem in the context of capacitor discharge in massless QED2 [1] by utilizing bosonization in two-dimensions. When the bare fermions are massless, the dual bosonized theory is free and capacitor discharge can be analyzed exactly [1], however, special care is required in its interpretation given that the theory exhibits confinement. In this paper we reinterpret the findings of [1], where the capacitors Schwinger-discharge via electrically neutral dipolar meson-production, and generalize this to the case where the fermions have bare masses. Crucially, we note that when the initial charge of the capacitor is large compared to the charge of the fermions, Q » e, the classical equation of motion for the bosonized model accurately characterizes the dynamics of discharge. For massless QED2, we find that the discharge is suppressed below a critical plate separation that is commensurate with the length scale associated with the meson dipole moment. For massive QED2, we find in addition, a mass threshold familiar from (3+1)-d, and show the electric field relaxes to a final steady state with a magnitude proportional to the initial charge. We discuss the wider implications of our findings and identify challenges in extending this treatment to higher dimensions.
The molecular identity of the TLQP-21 peptide receptor
Authors: Sahu Bhavani S. , Nguyen Megin E. , Rodriguez Pedro , Pallais Jean Pierre , Ghosh Vinayak , Razzoli Maria , Sham Yuk Y. , Salton Stephen R. , Bartolomucci Alessandro
Published: October 2021

The TLQP-21 neuropeptide has been implicated in functions as diverse as lipolysis, neurodegeneration and metabolism, thus suggesting an important role in several human diseases. Three binding targets have been proposed for TLQP-21: C3aR1, gC1qR and HSPA8. The aim of this review is to critically evaluate the molecular identity of the TLQP-21 receptor and the proposed multi-receptor mechanism of action. Several studies confirm a critical role for C3aR1 in TLQP-21 biological activity and a largely conserved mode of binding, receptor activation and signaling with C3a, its first-identified endogenous ligand. Conversely, data supporting a role of gC1qR and HSPA8 in TLQP-21 activity remain limited, with no signal transduction pathways being described. Overall, C3aR1 is the only receptor for which a necessary and sufficient role in TLQP-21 activity has been confirmed thus far. This conclusion calls into question the validity of a multi-receptor mechanism of action for TLQP-21 and should inform future studies.
Autologous chondrocyte implantation combined with anterior cruciate ligament reconstruction: similar short-term results in comparison with isolated cartilage repair in ligament intact joints
Authors: Mehl Julian , Feucht Matthias , Achtnich Andrea , Imhoff Andreas B. , Niemeyer Philipp , Angele Peter , Zinser Wolfgang , Spahn Gunter , Loer Ingo , Kniffler Heino , Schauf Gunnar , Schmitt Andreas
Published: October 2021

Purpose

Both acute ruptures of the anterior cruciate ligament (ACL) as well as chronic ACL insufficiency show a high association with focal cartilage defects of the knee. However, the results after combined ACL reconstruction and cartilage repair are not well investigated. The aim of the present study was to investigate the short-term outcomes after autologous chondrocyte implantation (ACI) in combination with ACL reconstruction and to compare the results with patients who underwent isolated ACI in ligament intact knees.

Methods

All patients who were registered in the German Cartilage Registry with ACI for focal cartilage defects in the knee joint in combination with ACL reconstruction and who completed the 24 month follow-up were included in the study group. A matched-pair procedure according to gender, defect location, defect size, and age was used to create a control group of patients with isolated ACI in ACL intact joints. The Knee Injury and Osteoarthritis Outcome Score (KOOS) and the numeric analog scale for pain (NAS) were used to assess the preoperative state as well as the clinical outcomes 12 and 24 months after surgery.

Results

A total of 34 patients were included in both the study group (age mean 33.3 ± SD 8.8 years) and the control group (33.6 ± 8.4 years) with a median defect size of 466 (25%-75% IQR 375–600) mm2 and 425 (IQR 375–600) mm2, respectively. In comparison with the preoperative state (median 67, IQR 52–75), the study group showed a significant increase of the total KOOS after 12 months (78, IQR 70–86; p = 0.014) and after 24 months (81, IQR 70–84; p = 0.001). The NAS for pain did not change significantly in the postoperative course. In comparison with the control group there was no significant difference for the total KOOS neither preoperative (control group median 67, IQR 52–73) nor at any postoperative time point (12 months: 82, IQR 67–93; 24 months: 81, IQR 71–91).

Conclusion

The clinical short-term outcomes after ACI at the knee joint in combination with ACL reconstruction are good and similar to the results after isolated ACI in ligament intact knees.

Level of evidence

III.
Facilitating sustainability control in SMEs through the implementation of an environmental management system
Authors: Johnstone Leanne
Published: October 2021

This paper explores the characteristic type and use of sustainability control in small to medium sized enterprises (SMEs) through the implementation of an environmental management system, formally certified to ISO 14001. Through a qualitative study of 18 SMEs and seven auditors operating in Northern Europe, the paper draws on the theoretical framework of sustainability control as an analytical tool to explore the interplay between the formal design of control instruments and the operational use of these in practice for the studied SMEs. The study finds that both the formalised control instrument design and operational use of these controls by employees are characteristically formal and procedure based for ISO 14001 certification. Nevertheless, environmental management in daily tasks is also achieved by engaging non-managerial employees through their passionate interests and intrinsic motivations. In extension to previous sustainability control research, the findings emphasise that local level operator knowledge is not only the product of formalised control system design, and that external factors are also important for guiding employee behaviour in situ. This proposes that daily working tasks are achieved through a combination of organisational and extra-organisational individual values and beliefs about sustainability. Particularly, engaging non-managerial employees in SMEs through a combination of extrinsic and intrinsic rewards appears valuable for sustainable futures. Therefore, in addition to compliance-driven controls, SME owner-managers should ensure supportive structures where employees are given the autonomy to be creative and innovative.
Combination of terbium-161 with somatostatin receptor antagonists—a potential paradigm shift for the treatment of neuroendocrine neoplasms
Authors: Borgna Francesca , Haller Stephanie , Rodriguez Josep M. Monné , Ginj Mihaela , Grundler Pascal V. , Zeevaart Jan Rijn , Köster Ulli , Schibli Roger , van der Meulen Nicholas P. , Müller Cristina
Published: October 2021

Purpose

The β¯-emitting terbium-161 also emits conversion and Auger electrons, which are believed to be effective in killing single cancer cells. Terbium-161 was applied with somatostatin receptor (SSTR) agonists that localize in the cytoplasm (DOTATOC) and cellular nucleus (DOTATOC-NLS) or with a SSTR antagonist that localizes at the cell membrane (DOTA-LM3). The aim was to identify the most favorable peptide/terbium-161 combination for the treatment of neuroendocrine neoplasms (NENs).

Methods

The capability of the 161Tb- and 177Lu-labeled somatostatin (SST) analogues to reduce viability and survival of SSTR-positive AR42J tumor cells was investigated in vitro. The radiopeptides’ tissue distribution profiles were assessed in tumor-bearing mice. The efficacy of terbium-161 compared to lutetium-177 was investigated in therapy studies in mice using DOTATOC or DOTA-LM3, respectively.

Results

In vitro, [161Tb]Tb-DOTA-LM3 was 102-fold more potent than [177Lu]Lu-DOTA-LM3; however, 161Tb-labeled DOTATOC and DOTATOC-NLS were only 4- to fivefold more effective inhibiting tumor cell viability than their 177Lu-labeled counterparts. This result was confirmed in vivo and demonstrated that [161Tb]Tb-DOTA-LM3 was significantly more effective in delaying tumor growth than [177Lu]Lu-DOTA-LM3, thereby, prolonging survival of the mice. A therapeutic advantage of terbium-161 over lutetium-177 was also manifest when applied with DOTATOC. Since the nuclear localizing sequence (NLS) compromised the in vivo tissue distribution of DOTATOC-NLS, it was not used for therapy.

Conclusion

The use of membrane-localizing DOTA-LM3 was beneficial and profited from the short-ranged electrons emitted by terbium-161. Based on these preclinical data, [161Tb]Tb-DOTA-LM3 may outperform the clinically employed [177Lu]Lu-DOTATOC for the treatment of patients with NENs.
Interclavicularis anticus digastricus muscle in a female body donor: a case report
Authors: Roesler M. K. , Schmeisser M. J. , Schumann S.
Published: October 2021

Background and objectives

Muscular variations of the ventral thoracic wall are generally common and of great clinical interest.

Materials and methods

An unusual muscular variation of the ventral thoracic wall was observed and dissected in a West-European female body donor.

Results

An interclavicularis anticus digastricus muscle was observed and studied. It originated from the manubrium sterni and inserted bilaterally to the clavicles. Both muscle bellies were interconnected by a tendon on the ventral surface of the manubrium sterni. The muscle was innervated by branches of the lateral pectoral nerve.

Conclusions

The interclavicularis anticus digastricus muscle is a muscular variation of the ventral thoracic wall of unknown prevalence. This variation might be of clinical interest in orthopaedics and thoracic surgery. It is also a vulnerable structure during infraclavicular insertion of a subclavian vein catheter or fractures of the clavicle.
Participative development and evaluation of a communication skills–training program for oncologists—patient perspectives on training content and teaching methods
Authors: Ernstmann Nicole , Nakata Hannah , Meurer Lena , Weiß Johanna , Geiser Franziska , Vitinius Frank , Petermann-Meyer Andrea , Burgmer Markus , Sonntag Bernd , Teufel Martin , Karger André
Published: October 2021

Background

Using the 6-step approach to curriculum development for medical education, we developed a communication skills training (CST) curriculum for oncology and evaluated this curriculum from the perspective of cancer patients.

Methods

We conducted a qualitative interview study with cancer patients, collecting data using semi-structured face-to-face or telephone interviews with a short standardized survey. We fully transcribed the audiotaped interviews and conducted the content analysis using MAXQDA 2020. We analyzed the quantitative sociodemographic data descriptively.

Results

A total of 22 cancer patients participated, having a mean age of 60.6 (SD, 13.2) years and being predominantly female (55%). The patients believed that the CST curriculum addressed important aspects of patient-centered communication in cancer care. They emphasized the importance of physicians acquiring communication skills to establish a trusting relationship between doctor and patient, show empathy, inform patients, and involve them in treatment decisions. The patients had some doubts concerning the usefulness of strict protocols or checklists (e.g., they feared that protocol adherence might disturb the conversation flow).

Discussion

Although it was a challenge for some participants to take the perspective of a trainer and comment on the CST content and teaching methods, the patients provided a valuable perspective that can help overcome blind spots in CST concepts.
Tectonics and fluvial dynamism affecting the Tiber River in Prehistoric Rome
Authors: Marra F. , Brock A. L. , Florindo F. , Macrì P. , Motta L. , Nicosia C. , Terrenato N.
Published: October 2021

Geomorphological investigations in Rome’s river valley are revealing the dynamism of the prehistoric landscape. It is becoming increasingly apparent that paleogeographic conditions that defined Rome in the historical era are the product of changes since the Bronze Age, which may be the result of local fault activity in addition to fluvial dynamism. Through a dedicated borehole chronostratigraphic study, integrated by14C and archaeological dates, and paleomagnetic investigations, we offer here new evidence for fault displacement since ca. 4500 years/BP. We present the failure of the sedimentary fabric of a clay horizon caused by liquefaction processes commonly linked with seismic shaking, interpreting an (ca. 4 m) offset to signify the existence of a fault line located at the foot of the Capitoline Hill. In addition, we show evidence for another (ca. 1 m) offset affecting a stratigraphic horizon in the river channel, occurring along another hypothesized fault line crossing through the Tiber Valley. Movement along this fault may have contributed to a documented phase of fast overflooding dated to the sixth century BCE which eventually led to the birth of the Tiber Island. The most plausible scenario implies progressive deformation, with an average tectonic rate of 2 mm/year, along these inferred fault lines. This process was likely punctuated with moderate earthquakes, but no large event necessarily occurred. Together, the available evidence suggests that during the early centuries of sedentary habitation at the site of Rome, active fault lines contributed to significant changes to the Tiber River valley, capable of challenging lowland activities.
A density-dependent multi-species model to assess groundwater flow and nutrient transport in the coastal Keauhou aquifer, Hawai‘i, USA
Authors: Okuhata Brytne K. , El-Kadi Aly I. , Dulai Henrietta , Lee Jonghyun , Wada Christopher A. , Bremer Leah L. , Burnett Kimberly M. , Delevaux Jade M. S. , Shuler Christopher K.
Published: October 2021

Fresh groundwater is a critical resource supporting coastal ecosystems that rely on low-salinity, nutrient-rich groundwater discharge. This resource, however, is subject to contamination from point- and nonpoint-sources such as on-site sewage disposal systems (OSDS) and urban developments. Thus, the significance of flow and transport processes near the coastline due to density effects and water circulation in a complex hydrogeologic system was investigated. A three-dimensional, density-dependent groundwater model was developed for the Keauhou basal aquifer (Hawai‘i Island, USA), where hydraulic head, salinity, nutrient concentrations, and submarine spring flux rates were used as calibration variables to best constrain parameters and produce a comprehensive aquifer management tool. In contrast, a freshwater-only model failed to properly simulate nutrient transport, despite the reasonable success in calibrating hydraulic head measurements. An unrealistic value for hydraulic conductivity was necessary for freshwater-only calibration, proving that hydraulic conductivity is a process-based variable (i.e., depends on model conceptualization and the simulated processes). The density-dependent model was applied to assess relative contaminant source contributions, and to evaluate aquifer response concerning water levels and quality due to changing environmental conditions. Nutrients detected in the aquifer are primarily sourced from OSDS, which was supported by a nitrogen isotope mixing model. Additionally, effects of sea-level rise emphasized the complexity of the study site and the importance of model boundaries. While the model is developed and applied for West Hawai‘i, the adapted approaches and procedures and research findings are applicable to other coastal aquifers.
Gender differences in cognitive reserve: implication for subjective cognitive decline in women
Authors: Giacomucci Giulia , Mazzeo Salvatore , Padiglioni Sonia , Bagnoli Silvia , Belloni Laura , Ferrari Camilla , Bracco Laura , Nacmias Benedetta , Sorbi Sandro , Bessi Valentina
Published: October 2021

Background

Subjective Cognitive Decline (SCD) is a self-experienced decline in cognitive capacity with normal performance on standardized cognitive tests, showing to increase risk of Alzheimer’s Disease (AD). Cognitive reserve seems to influence the progression from SCD to Mild Cognitive Impairment (MCI) and to AD. The aim of our study was to investigate gender differences in cognitive reserve evaluating how sex might modulate the role of cognitive reserve on SCD.

Methods

We included 381 SCD patients who underwent clinical evaluation, neuropsychological assessment, evaluation of premorbid intelligence by the Test di Intelligenza Breve (TIB), cognitive complaints by the Memory Assessment Clinics Questionnaire (MAC-Q), and apolipoprotein E (APOE) genotyping.

Results

The proportion between women and men was significantly different (68.7% [95% CI 63.9–73.4 vs 31.4%, 95% CI 26.6–36.0]). Women were younger than men at onset of SCD and at the baseline visit (p = 0.021), had lower years of education (p = 0.007), lower TIB scores (p < 0.001), and higher MAC-Q scores (p = 0.012). TIB was directly associated with age at onset of SCD in both women and men, while years of education was inversely associated with age at onset only in women. Multivariate analysis showed that sex influences TIB independently from years of education. TIB was directly associated with MAC-Q in men.

Conclusions

Sex interacts with premorbid intelligence and education level in influencing the age at onset and the severity of SCD. As the effect of education was different between men and women, we speculated that education might act as a minor contributor of cognitive reserve in women.
Remarks on the 3D Stokes eigenvalue problem under Navier boundary conditions
Authors: Falocchi Alessio , Gazzola Filippo
Published: October 2021

We study the Stokes eigenvalue problem under Navier boundary conditions in $$C^{1,1}$$

C

1
,
1

-domains $$\Omega \subset \mathbb {R}^3$$

Ω
⊂

R

3

. Differently from the Dirichlet boundary conditions, zero may be the least eigenvalue. We fully characterize the domains where this happens and we show that the ball is the unique domain where the zero eigenvalue is not simple, it has multiplicity three. We apply these results to show the validity/failure of a suitable Poincaré-type inequality. The proofs are obtained by combining analytic and geometric arguments.
Developmental characteristics of sporogenous hyphae: a new observation between Brassica juncea var. tumida and Albugo candida
Authors: Xiao Zilan , Gong Ning , Zhou Xiaojun , Zhu Liyan , He Xiaochan , Zheng Jingwu , Zhang Jingze
Published: October 2021

Brassica juncea var. tumida (tumorous stem mustard) is widely cultivated as a feature vegetable in Ningbo, Zhejiang Province, and is used as a raw material for pickles in China. White blister rust, caused by Albugo candida, has severe negative effects on tumorous stem mustard, resulting in significant economic losses. In this study, hypha colonization and extension, haustorial formation, and the development process of sporogenous hyphae and sporangia in A. candida-infected tissues were studied using light and transmission electron microscopy. Additionally, the complex and unique sporogenous hypha developmental process was revealed. During A. candida infection, cytological and ultrastructural characteristics were similar to those of cruciferous plants. During sporogenous hyphae development, an initially cylindrical sporogenous hypha with a thin inner wall at the apex developed from a cell with a thick inner wall. At the apical end of the sporogenous hypha, an electron-dense complex gathered, causing the disintegration of the inner and outer walls and the formation of new inner and outer walls. With the formation of a clavate sporogenous hypha, a deep constriction of the cell wall occurred at its subapex, in which a septum was produced and a primary sporangium was separated from the sporogenous hypha. Both layers of the sporogenous hypha wall took part in the formation of the sporangial wall but were not related the formation of the sporangial outer wall in a septum, providing direct evidence of the holoblastic formation of sporangia. Furthermore, ultrastructural observation demonstrated that the development of the primary sporangial walls within a septum occurred later than that of their lateral walls, including the degradation of constricted outer walls around the septum, formation of the inner wall and subsequent outer walls of a sporangium in the upper septum layers, confirming the earlier observation. Therefore, this study provided the model of sporogenous hyphae development and sporangial formation in chain.
The Use of Mobile Applications for the Diagnosis and Treatment of Tumors in Orthopaedic Oncology – a Systematic Review
Authors: Berger-Groch J. , Keitsch M. , Reiter A. , Weiss S. , Frosch KH. , Priemel M.
Published: October 2021

The use of smartphone apps is an essential part of everyday life. Mobile applications offer enormous opportunities for dealing with challenges in public health, and their number increases every day. This paper aims to review the existing literature on mobile applications in orthopaedic oncology and to summarize the current mobile applications for musculoskeletal tumors. A systematic literature review was conducted regarding articles on mobile applications in orthopaedic and trauma surgery. The focus was on identifying mobile applications that can be used in the treatment of patients with musculoskeletal tumors. Two reviewers independently assessed study eligibility, extracted data, and appraised methodological quality. In addition, the Apple App Store and Google Play Store were searched for suitable mobile applications. Ninety-one articles describing a mobile application in orthopaedic and trauma surgery were identified. Three articles focused on a mobile application for musculoskeletal tumors. Additionally, seven mobile applications were available in the App/Play Stores dealing with bone or soft tissue tumors in orthopaedic oncology without corresponding scientific articles. Increasing numbers of mobile applications are being developed in orthopaedic and trauma surgery. Currently, only three scientific articles on mobile applications in orthopaedic oncology are present, yet several more applications are available without scientific medical evaluation. Since mobile applications can facilitate the everyday life of orthopaedic and trauma surgeons, it is worthwhile to be aware of new developments in this field. A regular scientific evaluation of the subject is important in order to classify the significance of these applications.
Influence of PM1 exposure on total and cause-specific respiratory diseases: a systematic review and meta-analysis
Authors: Hu Yaoyu , Wu Mengqiu , Li Yutong , Liu Xiangtong
Published: October 2021

An increasing number of studies examined the potential effects of PM1 (submicronic particulate matter with an aerodynamic diameter ≤ 1 μm) on the risk of respiratory diseases; however, the results have been inconclusive. This study aimed to determine the overall association between PM1 with total and cause-specific respiratory diseases. A systematic review and meta-analysis was conducted with 68 related articles retrieved, and six articles met the full inclusion criteria for the final analysis. For a 10 μg/m3 increase in PM1, the pooled odds ratio (OR) was 1.05 (95% CI 0.98–1.12) for total respiratory diseases, 1.25 (95% CI 1.00–1.56) for asthma, and 1.07 (95% CI 1.04–1.10) for pneumonia with the I2 value of 87%, 70%, and 0%, respectively. Subgroup analyses showed that long-term exposure to PM1 was associated with increased risk of asthma (OR 1.47, 95% CI 1.33–1.63) with an I2 value of 0%, while short-term exposure to PM1 was not associated with asthma (OR 1.07, 95% CI 0.89–1.27) with the I2 value of 0%. Egger’s test showed that publication bias existed (P = 0.041); however, the funnel plot was symmetrical with the inclusion of the moderator. In conclusion, elevated levels of PM1 may increase morbidity in total and cause-specific respiratory diseases in the population.
Transcriptomic Responses of Potato to Drought Stress
Authors: Aliche Ernest B. , Gengler Tim , Hoendervangers Irma , Oortwijn Marian , Bachem Christian W. B. , Borm Theo , Visser Richard G. F. , van der Linden C. Gerard
Published: October 2021

Transcriptomic changes in plants during drought stress give insights into the mechanisms with which plants stabilise their metabolic processes in order to cope with the drought condition. In potato, understanding such drought-induced transcriptomic changes is critical because prolonged field drought interferes with tuber formation and bulking period of potato development, which eventually affects yield. We hypothesised that phenotypic drought responses of potato genotypes may be linked to differences in transcriptomic changes. Using an RNA sequencing approach, we investigated such transcriptomic changes in leaves of three cultivars (Biogold, Hansa and Lady Rosetta) under drought. We found more differentially expressed genes (DEGs) in the tolerant cultivars, Lady Rosetta and Biogold, than in the sensitive cultivar (Hansa). The differential gene expression trend reflected the phenotypic drought responses of the cultivars. For instance, we found in both Biogold and Lady Rosetta but not in Hansa, an upregulation of genes involved in carbohydrate metabolism (e.g., Alpha-glucosidase), flavonoid biosynthesis (e.g., Flavanone 3 beta-hydroxylase), lipid biosynthesis/transfer (e.g., nonspecific Lipid Transfer Proteins), heat shock proteins and secondary metabolites like phenolics and lignins. Furthermore, a prolonged drought stress resulted in reduced DEGs in Biogold and Hansa, but not in Lady Rosetta that also maintained its tuber yield under such prolonged stress suggesting a more robust drought tolerance. Our findings suggest that a synergistic expression of genes involved in several different aspects of drought response is required in order to obtain a robust tolerance.
Embrittlement Analysis of $$\sum {{{{5}\left[ {{21}0} \right]} \mathord{\left/ {\vphantom {{{5}\left[ {{21}0} \right]} {\left( {\overline{1}\overline{2}0} \right)}}} \right. \kern-\nulldelimiterspace} {\left( {-{1}-{2}0} \right)}}}$$ FeAl Grain Boundary in Presence of Defects: An Ab Initio Study
Authors: Lehenkari Touko , Aravindh S. Assa , Cao Wei , Alatalo Matti , Huttula Marko , Komi Jukka
Published: October 2021

Iron aluminide (FeAl) inter-metallic compounds are potential candidates for structural applications at high temperatures owing to their superior corrosion resistance, high temperature oxidation, low density and inexpensive material cost. However, the presence of defects can lead to reduction in the strength and ductility of FeAl-based materials. Here we present a density functional theory (DFT) study of the effect of the presence of defects including Fe and Al vacancies as well as H dopants at the substitutional and interstitial sites at a

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FeAl grain boundary focusing on the energetics. The plane wave pseudopotential code Vienna Ab initio Simulation Package (VASP) in the generalized gradient approximation (GGA) is used to carry out the computations. The formation energy calculations showed that intrinsic defects such as Fe and Al vacancies probably form at the GB, indicated by their negative formation energies. These vacancies can further form defect complexes with H impurities, indicated by lowered formation energies, compact bonds and charge gain of H atoms. Electronic structure analysis showed stronger hybridization of 1s orbitals of H with Fe and Al atoms, which leads to the stabilization of these defects resulting in degradation of material strength.
Olfactory disfunction and diabetic complications in type 2 diabetic patients: a pilot study
Authors: Mozzanica Francesco , Ferrulli Anna , Vujosevic Stela , Montuori Alessandro , Cardella Arianna , Preti Andrea , Ambrogi Federico , Schindler Antonio , Terruzzi Ileana , Ottaviani Francesco , Luzi Livio
Published: October 2021

Purpose

Scarce information on the prevalence and characteristics of olfactory disfunction (OD) in type 2 diabetic (T2D) patients are available. The aims of this study were (1) to assess the olfactory function in T2D patients and to compare it with a control group of individuals without T2D, and (2) to evaluate the differences in OD within T2D patients according to the presence of diabetic complications.

Methods

A group of 39 T2D patients and a control group of 39 healthy individuals were enrolled. Each subject underwent an evaluation of the olfactory performance using the Sniffing Olfactory Screening Test (SOST) and completed a questionnaire assessing the subjective perception of olfaction. According to the presence of diabetic complications, the group of T2D patients was divided into two subgroups. Non-parametric tests and regression analysis were used for statistical analysis.

Results

No differences in the subjective perception of olfaction were demonstrated among T2D patients (with and without complications) and controls. A significant difference for the SOST score was demonstrated among the different groups. In particular, OD was more frequent in T2D patients than in controls. In addition, OD was far more frequent in T2D patients with complications. Regression analysis did not demonstrate any significant association between OD and clinical/demographic characteristics of T2D patients.

Conclusion

T2D patients were more frequently affected by OD. The subgroup analysis suggested a possible relationship between OD and diabetic complications since patients with T2D diabetic complications demonstrated lower olfactory abilities than controls subjects and T2D patients without diabetic complications.
Cultural Historical Psychology and the Reset of History
Authors: del Río Pablo , Álvarez Amelia
Published: October 2021

The authors argue that, in the research trajectory of cultural historical psychology, there are nuclear aspects of Vygotsky’s theory that have been insufficiently considered. Three of these aspects are herein discussed: the intense and rapid changes to mediational processes and their influence on human psyche; meaningful findings on neuroplasticity that require a neuropsychological approach; and, perhaps most importantly, the need for cultural historical approach, and for psychology at large, to return to the study of the direction and meaning of human life.