bluuebunny/crossref_metadata_2025 huggingface dataset:
The relationship between follistatin and sarcopenia in elderly
Authors: Aryana I Gusti Putu Suka , Ida Bagus Putu Putrawan  , Ni Ketut Rai Purnami  , RA Tuty Kuswardhani  , I Nyoman Astika
Published: December 2022

Introduction: Sarcopenia is a multifactorial condition characterized by progressive and comprehensive mass loss accompanied by skeletal muscle strength or function. It can be triggered by physical inactivity, hormonal changes, energy, protein intake, oxidative stress and inflammatory processes. The state of inactivity underlying sarcopenia is related to follistatin levels.
Methods: an analytical cross-sectional study conducted in Posyandu or Elderly Associations in Denpasar City with subjects aged ≥60 years old started from January 2021 to September 2021. The data collected were anthropometric measurements, muscle mass, grip strength, walking speed and serum follistatin levels. Sarcopenia was diagnosed based on the AWGS criteria. Bivariate analysis was performed using the Mann-Whitney analysis to determine the difference in the mean of the independent variables and the Spearman's test to determine the relationship between sarcopenia and follistatin levels. 
Results: 75 subjects were selected, and 15 (20%) subjects were diagnosed with sarcopenia. The results of the Spearman correlation test of upper arm circumference, waist circumference, calf circumference, SMI, walking speed, hand grip strength and follistatin levels only found a significant negative relationship between waist circumference and follistatin levels r= -0,309, p= 0,016. No differences in mean follistatin levels with sarcopenia and non-sarcopenia group p= 0,516. There was no significant relationship between follistatin levels and sarcopenia p= 0,615.  
Conclusion: There is no correlation between follistatin levels and sarcopenia in the elderly. However, follistatin is inversely correlated with waist circumference.
All-inside vs. conventional method in anterior cruciate ligament (ACL) reconstruction: systematic review and meta-analysis
Authors: Rante Su Djie To , Santoso Asep , Sibarani Tangkas , Utomo Dwikora Novembri
Published: December 2022

Introduction: Injury to the anterior cruciate ligament (ACL) was prevalent among sports, with a female predominance. If not treated properly, ACL deficiency knee can cause significant morbidity and long-term impairment. The most often utilized reconstructive methods in modern clinical practice were conventional and all-inside treatments. This study compared all-inside and conventional ACL reconstruction methods through systematic review and meta-analysis.
Method: The searching protocol was carried out using several databases, such as PubMed, ScienceDirect, and Google Scholar, to identify relevant topics in May 2022. This study used the Preferred Reporting Items for Systematic Review and Meta-Analysis 2020 (PRISMA) guidelines.
Result: There were 17 studies included in this systematic review and meta-analysis. All of the reviewed studies were written in English. Most of the included studies were carried out in Europe. Theafollowaup duration range from 3amonthsato 4ayears. The total participants were 2329 patients with ACL reconstructions. There was a significant difference between groups in the overall analysis, with the all-inside technique having higher Lysholm score outcomes than the conventional technique (MD = 1.87; 95% CI = 0.41–3.33; p < 0.05)
Conclusion: All-inside technique has higher Lysohlm score outcome than the conventional technique. There is no significant difference in pain and IKDC score between both groups.
Analysis of liquid waste in weaving home industry at Nusa Penida, Klungkung, Bali, Indonesia
Authors: Sundari Cokorda Dewi Widhya Hana , Arjani Ida Ayu Made Sri , Krisna Luh Ade Wilan
Published: December 2022

Introduction: The existence of regulations using clothing made from traditional Balinese fabrics cloth called “endek” has caused the demand for woven fabrics to increase. One of the traditional woven fabric handicrafts starting to be recognized and favored by the public is the Cepuk and Rangrang woven fabric from island of Nusa Penida. Currently, liquid waste from weaving home industry activities has not been processed.  The purpose of the study was to measure the quality of liquid waste from the weaving home industry and compare it with the quality standards of liquid waste for businesses and or textile industry activities.
Method: This study was descriptive, conducted in Nusa Penida District, Klungkung Regency. The sample size was 25, taken by purposive sampling from nine craftsmen actively carrying out the production process with repetition three times. Measurement of liquid waste quality was carried out at the Laboratory of Panureksa Denpasar. The parameters examined are mandatory test parameters including physical parameters (temperature, TDS, TSS and color) and chemical parameters (total chromium, total ammonia, BOD5, COD, sulfide, oil and fat). Data analysis was carried out by comparing the measurement results with the Liquid Waste Quality Standards for Textile Industry Businesses and Activities according to Bali Governor Regulation 16 of 2016.
Result: The results showed an average temperature of 27.48o C, TDS levels of 6,095.20 mg/L, TSS 1,090.76 mg/L and color 2,216.56 TCU scale.  The chemical parameters showed average levels of total chromium 2.3912 mg/L, total ammonia 1.6068 mg/L, BOD5 675.84 mg/L, COD 1,286.72 mg/L, Sulfide 0.2395 mg/L, oil and fat 1,340 mg/L. Based on Bali Governor Regulation No. 16 of 2016, the parameters of temperature, total ammonia, Sulfide, Oil and Fat meet the quality standard requirements. While the parameters of TDS, TSS, color, total chrome, BOD and COD do not meet the quality standard requirements because it exceed the maximum allowable levels.
Conclusion:  It is recommended that weaving craftsmen carry out liquid waste treatment before disposal in the environment.
HUBUNGAN POSITIF ANTARA ULKUS KAKI DIABETIK DENGAN PERSENTASE SEL BERMARKAH CD4+ PEMBAWA MALONDIALDEHID
Authors: Putu SutirtaYasa I Wayan , Suastika Ketut , Sudewa Djelantik Anak Agung Gede , Mantik Astawa I Nyoman
Published: December 2022

Tingginya angka kejadian ulkus kaki diabetik (UKD) dan luka di kaki yangsulit sembuh memberi petunjuk kemungkinan ada proses kematian sel imun yangsangat banyak dan belum jelas mekanismenya secara molekuler pada jaringan UKD.Telah diteliti hubungan antara derajat UKD dengan persentase sel bermarkahCD4+ pembawa malondialdehid (MDA). Penelitian ini adalah penelitianobservasional dengan rancangan cross sectional analytic study yang dilakukan diRumah Sakit pemerintah dan swasta di Denpasar, Badung, Tabanan, dan Gianyar.Parameter yang diukur dari bahan darah adalah kadar gula darah memakai metodeenzimatik (heksokinase), dan dari bahan jaringan kaki, dihitung sel bermarkah CD4+pembawa MDA memakai metode imunohistokimia (reagen dari Biodesign danAbcam ). Dari 80 sampel UKD didapatkan 49 (61,2%) penderita laki-laki dan 31(38.8%) penderita wanita, berdasarkan tingkat keparahan UKD, sampel dipilah lagimenjadi: 29 (31,9%) derajat 2; 20 (21,9%) derajat 3; 13 (14,3%) derjat 4; dan18(19,8%) derajat 5, rata-rata persentase sel bermarkah CD4+MDA adalah 75,0 Â±20,5 %, Didapatkan korelasi positif kuat antara persentase sel bermarkah CD4+pembawa malondialdehid dengan derajat UKD (r = 0,71; p < 0,01). Pada penelitianini membuktikan ada mekanisme kematian sel imun dan sekaligus menjawabpermasalahan bahwa pada penderita UKD mudah terkena infeksi dan sulit untukdisembuhkan, dengan dibuktikan bahwa ada korelasi positif kuat antara derajat UKDdengan persentase pembentukan MDA dari sel bermarkah CD4+, ini menyatakanbahwa semakin berat derajat UKD semakin banyak mengalami kematian sel imun..
The Lactate/Pyruvate Ratio of Metabolic Modulation using Glucose Insulin Kalium and Lactate Solution and their Effect on Functional Mechanical Recovery of the Isolated Perfused Heart
Authors: Suranadi I Wayan , Bakta Made , Arhya I Nyoman , Leverve Xavier
Published: December 2022

Metabolic modulation with Glucose Insulin Kalium (GIK) solution has beenreally well known in their capacity to improve post ischemic heart function. In this regardGIK intervention on post operative Coronary Artery Bypass Graft (CABG) can improveheart function recovery on reperfusion period (Goldhaber dan Weiss, 1992; Atwell et al.,1997). Post operative CABG intervention with GIK will produce a beneficial effect onthe elevation of heart energy to prevent ionic homeostasis disturbance and reactiveoxygen species (ROS) production that become the basis of reperfusion injury (Silvermandan Stern, 1994; Cross et al., 1995; Taegtmeyer et al., 1997; Opie, 1999; Lazar, 2002;Doenst et al., 2003; Trence et al., 2003).Many efforts have been made to clarify how exactly GIK works to improve postischemic heart function as in CABG. This is crucially done in order to be able to modifythe solution concerned. Although this solution has been clearly proved to improve postischemic heart function, it is not totally free from its adverse effect. Its main side effect isthat it can provoke hyperglycemic state, which contrasts with the tight glucose control incontinuously normal range for the patients who are critically ill.In this study lactate and pyruvate level in the coronary effluent were measuredfrom the isolated heart directly perfused with GIK and lactate. It was shown that thepreischemic lactate level was low and then clearly elevated as soon as the reperfusiontook place due to anaerobic metabolism. In accordance with reperfusion time lactate leveldecreased gradually. In relation with pyruvate level, this substrate evolution looked likethe appearance of lactate but its value was lower if compared with lactate.The recovery in functional mechanical activity of the post ischemic heart seems tobe much more related to the pattern of the evolution of logarithmic lactate/pyruvate ratio(L/P ratio). Logarithmic value of L/P ratio in GIK group increased since the earlyreperfusion period (+40%, p < 0.05), followed by improvement in recovery ofmechanical activity in this group which was significantly higher if compared with thecontrol group. Similar fashion was found in lactate group in regard to the evolution of thelogarithmic value of L/P ratio in this group, where its value was significantly highercompared with the control group. The logarithmic evolution pattern on L/P ratio for thisgroup increased along the reperfusion time (+34% p < 0.05).From the present study, it can be concluded that the recovery of functionalmechanical activity of the post ischemic heart perfused with GIK is through modificationon cellular lactate metabolism.
HIGH PLASMA TNF-Î± LEVELS AND MONONUCLEAR CELLS iNOS AND TNF-Î± EXPRESSION AS RISK FACTORS FOR PAINFUL DIABETIC NEUROPATHY
Authors: Eko Purwata Thomas , Suastika Ketut , Raka Sudewi A. A. , Widjaja Djoenaidi
Published: December 2022

Painful Diabetic Neuropathy (PDN) is one of the most common and annoyingcomplications of diabetes mellitus. The pathogenesis of PDN is complex and still unclear.Recently it has become clear that nitric oxide (NO) and proinflammatory cytokines playan important role in the pathogenesis and maintenance of pain in PDN. Based on thisphenomenon, this study was conducted to investigate whether the cytokine tumornecrosis factor-alpha (TNF-Î±) and NO, in this case inducible Nitric Oxide Synthase(iNOS), play a role in PDN pathogenesis. The study was carried in two steps. The first step was a cross sectional and the second step was a case-control study. The study was performed in 110 type-2 diabetic patients. The plasma TNF-Î± levels were determined by ELISA while the expression of TNF-Î± and iNOS in mononuclear cells were analyzed immunohistochemically. Of 110 subjects, 59 patients suffered from Painful DN (case) and the remaining 51 patients were Painless DN (control). Cross sectionally, plasma TNF-Î± levels and immunoreactivity for iNOS and TNF-Î± were higher in patients with more severe pain in the Visual Analog Scale (VAS). There were statistically significant differences (p < 0.05) between mild and severe pain in regard to TNF-Î± level (15.24 pg/ml Â± 5.42 vs. 20.44 pg/ml Â± 10.34 ); to iNOS immunoreactivity (9.72 % Â± 8.61 vs. 15.6% Â± 11.84); and to TNF-Î± immunoreactivity (13.0 % Â± 9. 48 vs. 20.44% Â± 11.75). The case control study showed that TNF-Î± had an odd ratio of 5.053 [CI 95% (2.241-11.392); p < 0.001]. TNF-Î± immunoreactivity of 4.125 [CI 95% (1.805-9.425); p < 0.001]; and iNOS immunoreactivity of 3.546 [CI 95% (1.613-7.795); p = 0.002].Â There were correlations between TNF-Î± level, TNF-Î± and iNOS immunoreactivity and VAS with coefficient correlation: 0.330; 0.285 and 0.275 (p < 0.05) respectively. It is concluded that Diabetic Neuropathy patients with high TNF-Î± levels, iNOS and TNF-Î± immunoreactivity of mononuclear cells have higher risk for painful DN than painless DN. The higher TNF-Î± level, iNOS and TNF-Î± immunoreactivity the more severe was the pain. This supports the hypothesis that TNF-Î± and iNOS have role in PDN pathogenesis. The results of this research could be applied as a basic for further research in pursuit of better management of PDN
THE HUMORAL IMMUNITY RESPONSE OF DOG VACCINATED WITH ORAL SAG2 AND PARENTERAL RABISIN AND RABIVET SUPRA92
Authors: - Faizah , Mantik-Astawa IN , Putra AAG , - Suwarno
Published: December 2022

ABSTRACT This research aims to determine whether SAG2 oral vaccine induced antibody response as high as that of parenteral vaccine (Rabisin and Rabivet Supra 92). The experimental design applied was randomized pre and post control group design with 4 treatments (oral SAG2 vaccine, parenteral rabisin, parenteral Rabivet Supra 92 and control without vaccination) and with 9 replication. As many as 36 kampung dogs used and the anti rabies antibody was determined by enzyme-linked immunosorbent assay (ELISA) at day 0, 21, 56, 84, 119, and 147 post vaccination. The antibody titer induced by oral SAG2 vaccine raised more slowly but persisted longer than parenteral vaccine. On day 21 after vaccination, the average antibody titers induced by oral SAG2 vaccines (0.501 IU/ml) was still significantly lower than those induced by parenteral Rabisin (3.504 IU/ml) and Rabivet Supra92 (2.545 IU/ml). However, by day 119 after vaccination the average antibody titer induced by SAG2 oral vaccine (0.889 IU/ml) was significantly higher (p <0.05) as compared to those of parenteral Rabisin (0.625 IU/ml) and Rabivet Supra 92 (0.223 IU/ml). The antibody response induced by SAG2 oral vaccine appears to persist longer than parenteral vaccines and it can therefore be used as an alternative vaccine to combat rabies in animals, especially for dogs kept in free range.
ROLE OF EXCLUSIVE BREASTFEEDING AND S-IGA ANTIBODIES ANTIROTAVIRUS BREAST MILK TOWARDS RISK OF ACUTE ROTAVIRUS DIARRHEA IN INFANTS AGE OF 1-6 MONTHS: DO THEY CORELATE TO BREASTFEEDING "DAILY DOSE" AND ANTIBODY TITERS?
Authors: Lely Oka , - Soetjiningsih , Wibawa I D. N. , Mantik Astawa IN
Published: December 2022

Exclusive breastfeeding reduces the incidence of diarrhea, especially in children who live in densely populated neighborhood. This study aims to determine the relationship between exclusive breastfeeding and breast milk contains antirotavirus s-IgA antibodies towards risk of acute rotavirus diarrhea in infants aged of 1-6 months. Case-control study design is applied to determine the relationship between exclusive breastfeeding and breast milk contains s-IgA antibodies antirotavirus with risk of acute rotavirus diarrhea. Cases in this study were patients with acute rotavirus diarrhea and controls were patients without acute rotavirus diarrhea. Cases and controls were matched based on age. There were 23 cases and 69 controls. The proportion who received exclusive breastfeeding was 34.8% in cases and 34.4% in controls, with OR of 1.21 (95% CI: 0.45 to 3.28) and p = 0.28. Breast milk contains sIgA antibodies antirotavirus for case was 17.39% and controls was 23.2%, OR was 1.12 (95% CI: 0.29 to 4.29), p = 0.203. In conclusion, exclusive breastfeeding and breast milk contains sIgA antibodies antirotavirus were not associated with risk of acute rotavirus diarrhea in infants 1-6 months. This may be caused by differences in population and demographic studies as well as low of milk sIgA antibody antirotavirus titters. Further research of breastfeeding regardless of antirotavirus containing high antibody titters sIgA is needed.Â
CHARACTERISTIC AND CORRELATION BETWEEN TIME AND COMPLICATION AFTER DESTRUCTIVE EYE PROCEDURE PATIENT AT PLASTIC AND RECONSTRUCTION DIVISION SANGLAH HOSPITALâ€™S EYE CLINIC BALI-INDONESIA
Authors: Triharpini N , Sukartini D , Yuliawati P.
Published: December 2022

Destructive eye procedure can be carried out by enucleation, evisceration and excenteration. Some efforts have been developed to reduce the complications, but it still occur within several years after the operation. This research aims to find out the characteristic and correlation between time and complications in patient after destructive eye procedure at Plastic and Reconstruction Division Sanglah Hospitalâ€™s Eye Clinic. For addition, characteristic of other patients in plastic and reconstruction also provided. This report is an analytical cross sectional study. Data were collected retrospectively from medical report of patients with history of destructive eye procedure in Sanglah Hospitalâ€™s eye clinic from January 1st until December 31st 2010. Patientâ€™s characteristics were presented as frequency, percentage, mean, and standard deviation. Correlations between variables were statistically analyzed with Correlation of Lambda. Eye trauma, anophthalmic socket and nasolacrimal duct obstruction were the most common diagnosis at plastic and reconstruction division Sanglah Hospitalâ€™s eye clinic. There were 17 patients with history of destructive eye procedure in this report, including 76.5% male and 23.5% female. There is 58.8% destructive eye procedure held in age 13-50 year, mean 30.75 (SD 19.81). Infection (35.3%), trauma (23.5%) and tumor (11.8%) were the most common cause of destructive eye procedure in this study. Complications of destructive eye procedure occur in 70.6% of patient with contracted socket was the most common complication (58.3%). There was medium correlation between time and complication after the procedure, but the correlation was not statistically significant (r = 0.40; p > 0.05). In conclusion, from this study we obtained that there was medium correlation between time and complication after the procedure, but the correlation was not statistically significant.
THE RISK OF SQUAMOUS CELL CARCINOMA ON HUMAN PAPILLOMAVIRUS TYPE-16 INFECTION IN BALI
Authors: Mahendra-Dewi I G. A. S. , Suwiyoga I K.
Published: December 2022

The high risk of human papillomavirus (HPV) have already known widely and accepted as aÂ causative agent for cervical cancer. Epidemiologically, predominant high-risk is HPV-16 and squamous cellcarcinomas (SCC) is the most common histological type. HPV genotype probably correlates to histologictype. This study aims to determine how many fold is the risk of SCC on HPV-16 infection. This is a casecontrol with SCC HPV-16 positive as the cases and SCC HPV-16 negative as the controls. Tissues Â diagnosed as SCC and non SCC was paraffin-embedded. SPF-10 and specific E7-primer types by LiPA were employed for genotyping of HPV-16. ï£ï€²ï€ was applied to analyze the correlation. A number of 65 SCC consisted of 33 cases and 32 controls were observed in this study. The risk of SCC on HPV-16 infection was 3.40-fold (95% CI = 1.44-8.03; p = 0.004) compare with HPV-16 negative. Controls in this study consist of 18 (27.69%) of HPV-18, 9 (13.85%) of HPV-52, and 5 (7.69%) of other HPV types. The mean-age of case group and control group infected by HPV were 52.28 Â± 12.43 and 47.70 Â± 8.02 year, respectively (p = 0.02). HPV-16 infection caused SCC is 3.5 more than other high risk group.
ASSESSMENT OF HEALTH AND NUTRITIONAL STATUS UNDER THE INTEGRATED CHILD DEVELOPMENT SERVICES: in The Field Practice Area of Rural Training Health Centre, Nadayara, Travancore Medical College, Kollam-India
Authors: Sumit D. , Abraham J.
Published: December 2022

Assessment of health and nutritional status was carried out in Anganwadi Children in the Field Practice Area of Rural Training Health Centre, Nadayara, Travancore Medical College, Kollam. This is a cross sectional study within community base setting. Data were collected by a pretested structured questionnaire and analyzed by applying SPSS. Undernourished children in the Anganwadis under study were 21 %. Growth pattern of these children were significantly associated with the birth weight and the episodes of diarrhea. A significant proportion of children are missing the booster doses. DPT booster (16-24 months) is only 74.1 % and DT booster (5-6 years) is only a meager of 13.6%
PHOTOCHEMOPROTECTION OF CAULERA SPP ACTIVE COMPONENT ON RAT MODEL SKIN
Authors: Wiraguna A. A. G. P. , Pangkahila W. , Mantik-Astawa N.
Published: December 2022

CaulerpaÂ spp. including seaweed and macro-algae can be found in a large number at Coastal Serangan, Bali-Indonesia.Â Caulerpa sppÂ was historically used for food and vegetable. However, in our today life, this plant was applied as material for skin care products, especially for UV protection. The aim of this study is to know the active component ofÂ caulerpa sppÂ extract and its inhibition of premature skin aging induced by UV-B radiation through collagen expression. This was descriptive and experimental research applying a randomized posttest only control group design. Active component contained in theÂ caulerpa sppÂ extract are carotenoid, vitamin A, C, and E, polyphenols, minerals and amino acids. Topical application ofÂ caulerpa sppÂ can suppress the UV-B radiation induced collagen damage. Increased of collagen expression in all groups ofÂ caulerpa spp.Â just as good as astaxanthin group in improving collagen expression and 0.2% ofÂ caulerpa spp.Â extract is the most effective dose in improving collagen expression.
Ginjal tapal kuda dengan hidronefrosis unilateral sekunder akibat atresia ureter: laporan kasus
Authors: Darma Pratama Putu Kurnia , Duarsa Gede Wirya Kusuma , Nilawati Gusti Ayu Putu , Anandasari Pande Putu Yuli
Published: December 2022

Background: Total prevalence of multiple congenital anomalies (MCA) was 15.8 per 10,000 births. Genitourinary anomalies were associated with MCA cases about 43.8% of the cases. The horseshoe kidney is one example of genitourinary anomalies related to the high incidence of MCA and up to one third also had hydronephrosis thought to be secondary to ureteric atresia.Case: A 10-month-old boy presented with a 5-month history of abdominal distention. On physical examination, there was a large non-tender cystic mass in the right upper abdomen extending down to the right lower abdomen. The other congenital anomalies on this patient were hydrocephalus, hypospadias, and bilateral undescended testis. Abdominal CT showed a significant right hydronephrosis with megaureter and mesenteric cyst. The horseshoe kidney was unclear. The surgical approach to the kidney was via a transverse upper abdominal transperitoneal incision. Exploration revealed a horseshoe kidney with cystic mass situated retroperitoneally on the right side, massive dilatation of renal pelvis and proximal ureter 3 cm from UPJ. The distal ureter was markedly atresia. It was decided to perform nephroureterectomy on the right side considering its thin renal cortex. The postoperative average urine production is 25 ml/hour, no bleeding from surgical wound, BUN 10.7 mg/dL, and serum creatinine 0.37 mg/dL.Conclusion: The horseshoe kidney is one example of genitourinary anomalies related to the high incidence of MCA. Up to one third with horseshoe kidney had hydronephrosis secondary to ureteric atresia, which can be managed by reconstruction surgery or nephroureterectomy considering the function of the affected side of kidney.Â
Perbandingan outcome penanganan pembedahan dan tanpa pembedahan pada fraktur radius distal di RSUP Sanglah periode April 2016-Agustus 2017
Authors: DwiKrisna Putu Prabhawati , Subawa I Wayan , Agung Artha Wiguna IGL Ngurah
Published: December 2022

Background: Fracture of the distal radius is one of the most common fractures of the wrist. The incidence of fracture of the distal radius increases in each year. Management on the fracture of the distal radius can be grouped into two ie surgery and without surgery.Aim: This study aims to determine the comparison of successful treatment between fracture of distal radius surgically and without surgery.Method: This research used descriptive cross-sectional approach which is conducted at Sanglah General Hospital (RSUP) Denpasar. Data obtained was secondary data in the form of patient's medical record from April 2016 - August 2017 as well as primary data from patient interview. Data were analyzed using SPSS program.Result: This study indicated that the most involved gender was men classified as adult (25-59 years). The incidence of most fracture of distal radius was caused by traffic accidents. It also obtained that there were no different outcomes between surgical and non-surgical therapy in patients with fracture of distal radius.Conclusion: The comparison of surgical and non-surgical outcome at distal radius do not show significant differences statistically. Fraktur radius distal adalah salah satu dari macam fraktur yang biasa terjadi pada pergelangan tangan. Angka kejadian fraktur radius distal meningkat di setiap tahunnya. Penatalaksanaan pada fraktur radius distal dapat dikelompokan menjadi dua yaitu pembedahan dan tanpa pembedahan.Tujuan: Tujuan penelitian ini yaitu untuk mengetahui perbandingan keberhasilan terapi penanganan fraktur radius distal dengan pembedahan dan tanpa pembedahan.Metode: Penelitian ini menggunakan metode penelitian deskriptif dengan pendekatan cross-sectional yang dilakukan di Rumah Sakit Umum Pusat (RSUP) Sanglah Denpasar. Data yang diperoleh berupa data sekunder rekam medis pasien periode April 2016 – Agustus 2017 dan data primer dari wawancara pasien. Data dianalisis dengan menggunakan program SPSS.Hasil: Penelitian ini menunjukkan bahwa jenis kelamin terbanyak yaitu pada laki-laki tergolong dewasa (25-59 tahun). Insiden fraktur radius distal terbanyak disebabkan oleh kecelakaan lalulintas. Penelitian ini juga mendapatkan hasil tidak terdapat perbedaan hasil outcome terapi pembedahan dan tanpa pembedahan pada pasien fraktur radius distal.Kesimpulan: Perbandingan outcome penanganan pembedahan dan tanpa pembedahan pada fraktur radius distal tidak menunjukan perbedaan yang signifikan secara statistic.
Weightlifting-related injuries
Authors: Peter Jonathan David Rajaratnam , Griadhi I Putu Adiartha
Published: December 2022

Background: Each year, more and more athletes partake in weightlifting, aiming to outperform their predecessors and achieve new records of feats of strength. However, even despite the newer knowledge of biomechanics, and the safety precautions taken to prevent injury, such events still do take place.Aim: The study aims to determine the sources of these injuries, as well as the more frequent parts of the body that get injured, those more prone to it.Conclusion:  The numerous injuries that can be sustained during weightlifting has been noted including its causes, as well as its effect on an individual and the incidence rate of the occurrence in professional weightlifters.
Skin lesion of hidradenitis suppurativa mimicking lymphogranuloma venereum: a case report
Authors: Pratama Akbar , Nurdin Diany
Published: December 2022

Background: Hidradenitis suppurativa clinical appearance is painful, deep-seated inflamed lesions, most commonly found on axillary, inguinal, anogenital regions. It should be differentiated with primary cutaneous bacterial infection (abscesses, carbuncles, or furunculosis) and rare conditions such as lymphogranuloma venereum.Case: we report a 50-year-old male presenting with an unusual clinical presentation of hidradenitis suppurativa located in suprapubic such as bilateral fluctuant and suppurative nodules resembling lymphadenitis, led to an initial diagnosis of lymphogranuloma. We excluded lymphogranuloma diagnosis based on the serology test of Chlamydia trachomatis, bacterial cultures, and sensitivity tests. The results were non-reactive for the Chlamydia trachomatis serology test, and Staphylococcus aureus was found in bacterial culture.Conclusion: clinicians must be aware of diagnosis precisely, prevent the recurrent, and improve the prognosis.
Analisis kesesuaian pemakaian obat pada pasien asma dewasa dengan Peraturan Menteri Kesehatan Nomor 5 tahun 2014 di Badan Rumah Sakit Umum Daerah Kabupaten Tabanan tahun 2018
Authors: Gita Desak Gede Vicsilia Mahambara , Ernawati Desak Ketut , Mahendra Agung Nova
Published: December 2022

Background: Regulation of the Minister of Health of the Republic of Indonesia No. 5 of 2014 concerning asthma mentions the presence of types of asthma, medication controller, alternatives such as drugs and substances that have been determined and also other alternatives such as additional drugs. The drugs used in the guidelines were glucocorticosteroids, theophylline, chromolin, leukotriene modifiers, ventolin, and formeterol. Nowadays, the number of asthmatic patients who received asthma therapy according to that regulations had not been clearly distributed.Aim: The study aims to describe the pattern of drug use in adult asthma patients in accordance with the regulations in Tabanan General Hospital.Methods: A retrospective observational study with medical record data without providing intervention or treatment to samples in the Tabanan General Hospital in March-June 2019 aged 18-65 years and receiving asthma medication.Results and Conclusions: The three types of asthma, based on the type of drug, dosage, and dosage form are not in accordance with Regulation of Minister of Health No. 5 of 2014.  Peraturan Menteri Kesehatan (PMK) Republik Indonesia No 5 Tahun 2014 tentang asma menyebutkan adanya jenis asma, medikasi pengontrol, alternatif seperti obat dan zat yang telah ditentukan dan juga alternatif lain seperti tambahan obatnya. Obat yang digunakan pedoman PMK No 5 Tahun 2014 yaitu glukokortikosteroid, teofilin, kromolin, leukotrien modifiers, ventolin, formeterol. Sampai sekarang jumlah pasien asma yang mendapatkan terapi asma sesuai dengan PMK masih belum terdistribusi dengan jelas.Tujuan: untuk mendeskripsikan pola penggunaan obat pada pasien asma dewasa sesuai dengan PMK No 5 Tahun 2014 yang berlaku di Badan Rumah Sakit Umum Daerah (BRSUD) Kabupaten Tabanan.Metode: Penelitian observasional retrosprektif dengan data rekam medis tanpa memberikan intervensi atau perlakuan pada sampel di BRSUD Kabupaten Tabanan pada bulan Maret-Juni 2019 berusia 18-65 tahun dan mendapatkan terapi obat asma.Hasil dan Simpulan: Ketiga jenis asma, berdasarkan jenis obat, dosis, dan bentuk sediaan tidak sesuai dengan PMK No 5 Tahun 2014.
Graves’ disease: A review in diagnosis and management
Authors: Dwisaputra I Gusti Ngurah Bagus Hindra , Prabawa I Made Yoga
Published: December 2022

Background: Graves’ disease is the leading cause of hyperthyroidism condition in the world. The incidence of Graves’ disease in the world reaches 20-50 cases per 100,000 population per year. Graves’ disease can cause somatic, psychiatric, and cosmetic problems in the patient. In some cases, it caused a decreased quality of life and death if not appropriately managed. Hence, appropriate diagnosis and management should be made to prevent the progression of the disease.Aim: This literature review aims to review the diagnosis and management of Graves’ disease.Conclusion: Graves’ disease is an autoimmune disease that causes hyperthyroidism by stimulating the thyroid gland to produce thyroid hormone. History taking and laboratory investigation can be done to establish a diagnose of Graves’ disease. Treatment, including the use of anti-thyroid drugs, radioiodine therapy, and surgery. Monitoring should be done periodically during and after the course of treatment to prevent relapse.
Comparison between negative pressure and conventional wound dressing for diabetic foot ulcer: A systematic review
Authors: Jayaningrum I Gusti Ayu Agung Bella , Putri Anak Agung Istri Ayu Detritha Sarasmartha , Clarresa Pretty
Published: December 2022

Background: Diabetic foot ulcer (DFU) is a common complication of diabetes mellitus (DM), resulting in loss of limb or life. Negative pressure wound therapy (NPWT) is an emerging therapeutic option in the management of DFU. This study aims to compare the efficacy of NPWT to conventional moist wound dressing in the management of DFU.Methods: Literature was searched from online public scientific databases, including PubMed, Google Scholar, ScienceDirect, and Portal Garuda. Our review included clinical trials and analytic studies comparing NPWT and conventional moist dressing to treat DFU published in 2017 or later. Outcome measures include the proportion of wound healing, healing time, ulcer size reduction, granulation time, amputation, infection, and bleeding.Results: We include 11 articles, including eight randomized clinical trials (RCTs), two retrospective analytic studies, and one non-random clinical trial. There was methodological variation between studies on the application of NPWT, outcome measures reported, and length of follow up. Results mostly showed NPWT yielded a higher proportion of complete wound healing, shorter healing time, granulation time, and faster ulcer size reduction rate. However, NPWT was not associated with a reduction of amputation risks.Conclusions: Our review found NPWT was superior in short-term treatment outcomes such as granulation time and wound closure; however, there was no difference in reducing amputation risk between NPWT and conventional moist dressing. Results are inconclusive due to variation in methodologies of included articles.
Dramatic improvement in severe-critical COVID-19 patient after tocilizumab administration: a clinical experience
Authors: Kurniawati Yesicha , Atmaja Kadek Surya , Suryana Ketut , Putra Wayan Wahyu Semara
Published: December 2022

Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections in coronavirus disease 2019 (COVID-19) involve so many inflammatory cytokines, especially Interleukin-6 (IL-6). The usage of tocilizumab as an anti-IL-6 receptor antibody had been approved as COVID-19 medication.Case Presentation: This article reports a 51-year-old woman diagnosed with severe-critical COVID-19. The patient made significant progress after tocilizumab administration. The patient was hospitalized for 14 days before being discharged.Conclusion: Tocilizumab administration showed a significant improvement in COVID-19 patients.  However, further investigations are needed to explain this further.
Surgical excision with paramedian forehead flap reconstruction in recurrent basal cell carcinoma of the nose
Authors: Willyanto Nathan Aditya , Huda Samsul
Published: December 2022

Background:  Basal cell carcinoma (BCC) is the most common malignancy worldwide, especially in fair-skinned people. Along with squamous cell carcinoma (SCC), these malignancies are grouped as non-melanoma skin cancer (NMSC). The nose is a common site for BCC because it is exposed to the sun. The rates of recurrence are variable in the literature, between 10% and 67%. The ideal surgical treatment for BCC is complete tumor removal with safety margins. Wide excision of the BCC will leave the nose with a soft tissue defect and sometimes part of cartilage or skeleton, which requires nasal reconstruction.Case presentation: An 80-year-old female was admitted to the General Surgery Department of Soebandi General Hospital Jember presenting with ulceration on the right side of her nose 4 months before admission. The patient had a previous history of surgical excision on the nose 15 years ago on the nose's left side.Conclusion: Recurrent cases of BCC are still the main issue in treating BCC. Wide excision of the BCC will leave the nose with a soft tissue defect, which requires nasal reconstruction. The paramedian forehead flap is recommended for defect closure in nasal reconstruction.
Prosedur tato kornea: sebuah laporan kasus
Authors: Alexander Tiara , Cahyaningsih Eunike
Published: December 2022

Background: Leukoma adherent is a condition where the formation of white cicatrix with iris incarceration involvement of the cornea. In addition to causing a decrease in visual acuity and blindness, leukoma adherent can also interfere with the appearance of the patient's eye. Corneal tattoo or keratopigmentation (KTP) is a procedure that disguises the color of the leukoma according to the color of the patient's eyes or irises. Corneal tattoo procedures can be performed superficially, intrastromal, or with a femtosecond laser. Corneal tattoo procedures can be carried out in various ways. It is necessary to study keratopigmentation thoroughly.Case: An 18-year-old male patient complained of white patches on his left eye, expanding for a year. The first spots appeared five years ago after being exposed to wood. On physical examination, visual acuity was 1/~ in the left eye and 20/20 in the right eye. The patient underwent a corneal tattoo on the left eye using Vicryl 7.0 with Chinese ink.Conclusions: Corneal tattoo with intrastromal technique is one of the commonly used techniques. This procedure can use a suture needle or an angled knife to introduce the ink. The results of this procedure are quite satisfactory. However, the patient must still be educated on the possibility of further action for color fading or other complications that can harm the eyes.  Latar belakang: Leukoma adherent merupakan kondisi terbentuknya sikatriks berwarna putih dengan keterlibatan inkarserasi iris pada kornea. Selain menyebabkan penurunan tajam penglihatan dan kebutaan, leukoma adherent juga dapat mengganggu penampilan mata pasien. Tattoo kornea atau kerato pigmentasi (KTP) merupakan prosedur yang menyamarkan warna leukoma sesuai dengan warna mata atau iris pasien. Prosedur tato kornea dapat dilakukan superfisial, intrastromal, ataupun dengan femtosecond laser. Prosedur tattoo kornea dapat dilaksanakan secara beragam, maka diperlukan studi yang membahas prosedur tattoo kornea secara menyeluruh.Kasus: Pasien laki-laki usia 18 tahun mengeluhkan bercak putih pada mata kiri yang semakin meluas sejak setahun. Bercak pertama kali timbul sejak 5 tahun lalu, setelah mata kiri terkena kayu. Pada pemeriksaan fisik didapatkan tajam penglihatan 1/~ pada mata kiri dan 20/20 pada mata kanan. Pasien menjalani tindakan tattoo kornea pada mata kiri menggunakan vicryl 7.0 dengan tinta cina.Simpulan: Tattoo kornea dengan teknik intrastromal merupakan salah satu teknik yang umum digunakan. Prosedur ini dapat menggunakan suture needle ataupun angled knife untuk mengintroduksi tinta. Hasil dari prosedur ini cukup memuaskan namun pasien tetap harus diedukasi kemungkinan tindakan lanjutan atas peluruhan warna ataupun komplikasi lain yang dapat membahayakan mata.
Kadar 25(OH)D dan rasio HDL-LDL serum yang rendah sebagai faktor risiko terjadinya preeklamsia dengan gambaran berat
Authors: Lim Leony , Suwiyoga Ketut , Putra I Wayan Artana , Kusuma Anak Agung Ngurah Jaya , Putra I Gede Mega , Suardika Anom , Megadhana I Wayan
Published: December 2022

Background: Preeclampsia is a health problem because it contributes to high rates of maternal and baby morbidity and mortality. The pathogenesis of preeclampsia is still unknown, but vitamin D deficiency and low HDL-LDL serum ratio are thought to play an important role. Therefore, a study was conducted on low 25(OH)D serum level and low HDL-LDL serum ratio as risk factors for preeclampsia with severe features.Methods: This study has a case-control design, conducted at Obstetric and Gynecology emergency room at Sanglah Hospital from January 2020 to June 2020. Subjects were 44 pregnant women, consisting 22 normal pregnant women as controls and 22 pregnant women with preeclampsia with severe features as cases, selected by purposive consecutive sampling and analyzed using SPSS 21.Results: Preeclampsia with severe features was found 5 times higher in pregnant women with low 25(OH)D serum level than in normal pregnant women (OR = 4,91, CI 95% = 1,33-18,21, p = 0,014). Preeclampsia with severe features was found 8 times higher in pregnant women with low HDL-LDL serum ratio than in normal pregnant women (OR = 7,88, CI 95% = 1,96-31,57, p = 0,002).Conclusion: Low 25(OH)D serum level and low HDL-LDL serum ratio are risk factors for Preeclampsia with severe features. Pendahuluan: Preeklamsia merupakan masalah kesehatan karena berkontribusi terhadap tingginya angka morbiditas dan mortalitas ibu dan bayi. Patogenesis preeklamsia sampai saat ini masih belum diketahui secara pasti, namun kadar vitamin D dan rasio HDL–LDL serum yang rendah diduga berperan penting dalam mekanisme terjadinya preeklamsia. Penelitian kemudian dilakukan terhadap kadar 25(OH)D dan rasio HDL-LDL serum yang rendah sebagai faktor risiko terjadinya preeklamsia dengan gambaran berat.Metode : Desain penelitian ini adalah kasus kontrol (case control) yang dilakukan di Instalasi Gawat Darurat Obstetri dan Ginekologi RSUP Sanglah, Denpasar mulai Januari 2020 sampai Juni 2020. Subyek penelitian berjumlah 44 orang ibu hamil, yang terdiri dari 22 ibu hamil normal sebagai kontrol dan 22 ibu hamil dengan preeklamsia dengan gambaran berat sebagai kasus, yang dipilih secara purposive consecutive sampling,  dan dianalisis menggunakan SPSS 21.Hasil: Risiko terjadinya preeklamsia dengan gambaran berat  adalah 5 kali lebih tinggi pada ibu hamil dengan kadar 25(OH)D serum yang rendah dibandingkan ibu hamil normal (OR = 4,91, IK 95% = 1,33-18,21, p = 0,014). Risiko terjadinya preeklamsia dengan gambaran berat adalah 8 kali lebih tinggi pada ibu hamil dengan rasio HDL-LDL serum yang rendah dibandingkan ibu hamil normal (OR = 7,88, IK 95% = 1,96-31,57, p = 0,002).Simpulan : Kadar 25(OH)D dan rasio HDL-LDL serum yang rendah merupakan faktor risiko preeklamsia dengan gambaran berat.
Description of hydrocephalus knowledge in pregnant woman at Puskesmas 1 Denpasar Utara
Authors: Prathiwindya Made Indra Erlangga , Niryana I Wayan , Mahadewa Tjokorda Gde Bagus , Maliawan Sri
Published: December 2022

Background: Hydrocephalus is a pathological brain disorder resulting from increased cerebrospinal fluid without or with elevated intracranial pressure resulting in widening of the space where cerebrospinal fluid flows. Maternal environment such as experiencing infection during pregnancy, consuming alcohol and drugs, lifestyle such as obesity, diabetes, or hypertension, and lack of examinations in preparing for prenatal care and low socioeconomic status affect the risk factors for congenital hydrocephalus. The purpose of this study is to to determine awareness and knowledge level among pregnant women towards hydrocephalus.
Methods: This descriptive research was conducted with a cross-sectional method using consecutive sampling as a sampling technique. 106 Pregnant Women at Puskesmas I Denpasar Utara was involved in completing the survey regarding Hydrocephalus during this research. For the collecting data using a questionnaire filled directly by each respondent containing 9 questions and then analyzed using the software Statistical Package for the Social Sciences (SPSS).
Results: This study was participated by 106 respondents and figured that approximately 84,9% among the total number of respondents have a good knowledge of hydrocephalus while the rest, 15,1% are still at a low level with common characteristics of the respondents, including the age of 24 years old (age group 19-25), multipara (59.4%), with a college education background (45.3%), and working as a housewife (59.4%).
Conclusion: This study conveys good knowledge about hydrocephalus in pregnant women, especially those who have a good level of education.
Penanganan inversio uteri: sebuah tinjauan pustaka
Authors: Widiyanti Endang Sri , Putra I Gede Mega
Published: December 2022

Acute uterine inversion is a rare but life-threatening emergency in the field of obstetrics. The main signs and symptoms of acute uterine inversion are bleeding and shock. The accuracy and speed of diagnosis and case management will reduce morbidity and mortality due to uterine inversion. This literature review is expected to increase our knowledge as practitioners in dealing with uterine inversion cases. In principle, there are two goals for the treatment of acute uterine inversion, namely repositioning the uterus and treating the shock that occurs. The success of uterine inversion repositioning is highly dependent on the speed of early detection. The longer the uterus is inverted, the more difficult it will be to reposition it. There are several non-surgical techniques for repositioning the uterus, including: Johnson maneuver, Henderson and Alles maneuver, use of tocolytics, and repositioning with hydrostatic pressure. Surgical procedures can be performed abdominally, namely the Huntington's Procedure, with abdominal repositioning laparotomy and the Haultain's Procedure, with abdominal cervical repositioning-repositioning laparotomy. Kejadian inversio uteri akut merupakan kegawatdaruratan di bidang Obstetri yang jarang terjadi namun mengancam nyawa. Tanda dan gejala utama inversio uteri akut adalah perdarahan dan syok. Ketepatan dan kecepatan diagnosa dan penanganan kasus akan mengurangi morbiditas dan mortalitas akibat inversio uteri. Tinjauan pustaka ini diharapkan dapat menambah pengetahuan kita sebagai praktisi dalam menangani kasus inversio uteri. Pada prinsipnya ada dua tujuan penanganan inversio uteri akut, yaitu reposisi uterus dan penanganan syok yang terjadi. Keberhasilan reposisi inversio uteri sangat tergantung pada kecepatan deteksi dini. Semakin lama uterus terinversi akan semakin sulit melakukan reposisi. Terdapat beberapa teknik non-bedah untuk reposisi inversio uteri, antara lain: manuver Johnson, manuver Henderson dan Alles, penggunaan tokolitik, dan reposisi dengan tekanan hidrostatik. Prosedur pembedahan dapat dilakukan melalui abdominal, yaitu Prosedur Huntington, dengan laparotomi-reposisi melalui abdominal dan Prosedur Haultain, dengan laparotomi- insisi cincin servikalis-reposisi melalui abdominal.
The microvascular reconstruction in children with maxillofacial defects: A Systematic Review
Authors: Valentin Violetti , Roosseno Ratna Rayeni Natasha
Published: December 2022

Background: Facial bones trauma in the pediatric population is linked to severe damage and impairment, particularly in maxillofacial, particularly in area. In addition, reconstruction of maxillofacial in pediatric patients has some unique considerations. Therefore, this study described the effectiveness of microvascular reconstruction in children with maxillofacial defects.Methods: The relevant literature from PubMed and Science Direct databases. The strategic search is using the keywords such as "Pediatric" OR "Children" OR "Under-eighteen years" AND "microvascular reconstruction" OR "microvascular surgery" AND "maxillofacial defect". We used a PRISMA method to the selection of those articles. The inclusion criteria were related to microvascular reconstruction in children with maxillofacial defects from 2000-2021.Result: Total of six studies entries with inclusion criteria. These studies show that most free flaps or microvascular reconstruction procedures carried on pediatric patients to resolve maxillofacial defects gave successful functional, and clinical outcomes. In addition, a few complications, mainly infections, occurred following the surgery, however successfully managed with antibiotics.Conclusion: A microvascular reconstruction is a good option for maxillofacial defects reconstruction in pediatric patients due to a shorter surgical time and faster recovery.