bluuebunny/crossref_metadata_2025 huggingface dataset:
Label-free impedimetric immunosensor for point-of-care detection of COVID-19 antibodies
Authors: Shoute Lian C. T. , Abdelrasoul Gaser N. , Ma Yuhao , Duarte Pedro A. , Edwards Cole , Zhuo Ran , Zeng Jie , Feng Yiwei , Charlton Carmen L. , Kanji Jamil N. , Babiuk Shawn , Chen Jie
Published: January 2023

The COVID-19 pandemic has posed enormous challenges for existing diagnostic tools to detect and monitor pathogens. Therefore, there is a need to develop point-of-care (POC) devices to perform fast, accurate, and accessible diagnostic methods to detect infections and monitor immune responses. Devices most amenable to miniaturization and suitable for POC applications are biosensors based on electrochemical detection. We have developed an impedimetric immunosensor based on an interdigitated microelectrode array (IMA) to detect and monitor SARS-CoV-2 antibodies in human serum. Conjugation chemistry was applied to functionalize and covalently immobilize the spike protein (S-protein) of SARS-CoV-2 on the surface of the IMA to serve as the recognition layer and specifically bind anti-spike antibodies. Antibodies bound to the S-proteins in the recognition layer result in an increase in capacitance and a consequent change in the impedance of the system. The impedimetric immunosensor is label-free and uses non-Faradaic impedance with low nonperturbing AC voltage for detection. The sensitivity of a capacitive immunosensor can be enhanced by simply tuning the ionic strength of the sample solution. The device exhibits an LOD of 0.4 BAU/ml, as determined from the standard curve using WHO IS for anti-SARS-CoV-2 immunoglobulins; this LOD is similar to the corresponding LODs reported for all validated and established commercial assays, which range from 0.41 to 4.81 BAU/ml. The proof-of-concept biosensor has been demonstrated to detect anti-spike antibodies in sera from patients infected with COVID-19 within 1 h.
Endophytes as nature’s gift to plants to combat abiotic stresses
Authors: Godara Himanshi , Ramakrishna Wusirika
Published: January 2023

In recent decades, scientists have recognized that plants’ distinct and immensely dynamic microbial communities are more than just “passengers,” but instead, play an important role in their development, and shielding against abiotic and biotic stresses. Endophytes comprise fungi and bacteria that live within plant tissues and support growth when plants are under stress. All plants in nature are considered to have symbiotic association with endophytes. A comprehensive review of the accessible data suggests that mobility, cell-wall degradation capacity, and reactive oxygen species scavenging are critical attributes for the successful colonization of endophytes. Plants encounter several abiotic stresses caused by climate change and global warming, which have an effect on their growth and production. Abiotic stress like high temperature, salinity, and high precipitation can severely affect plants compared to biotic stress. This review aims to highlight what role endophytes play to aid plant growth under abiotic stress conditions like heat, salinity, and drought. In the current review, we discuss how endophytic microbes can be efficiently used for the improvement and promotion of plant growth and crop production under abiotic stress conditions.
The light curve simulations of the 2021 anomalous event in SS Cygni
Authors: Kimura Mariko , Osaki Yoji
Published: January 2023

The prototype dwarf nova SS Cyg unexpectedly exhibited an anomalous event in its light curve in the early few months of 2021 in which regular dwarf nova-type outbursts stopped, and only small-amplitude fluctuations occurred. Inspired by this event, we have performed numerical simulations of light curves of SS Cyg by varying mass transfer rates and varying viscosity parameters in the cool disk. We have also studied the effect of gas-stream overflows beyond the outer disk edge in the light curve simulations. We have confirmed that the enhanced mass transfer is not likely to be responsible for the 2021 anomalous event or its forerunner. We have found that the enhancement of the viscosity in the disk may reproduce the forerunner of that event but may not be sufficient to explain the 2021 anomalous event, although the latter result might be particular to the thermal equilibrium curve we used. Within our simulations, a model of the gas-stream overflow with a slightly higher mass transfer rate than that of our standard model reproduces light curves similar to the 2021 anomalous event. We suggest that the gas-stream overflow is necessary to reproduce that event. The gas-stream overflow may also be responsible for the abnormally high X-ray flux during the normal quiescent state in SS Cyg.
Genome Sequence Resource of Fusarium proliferatum f. sp. malus domestica MR5, the Causative Agent of Apple Replant Disease
Authors: Duan Y. N. , Ma S. R. , Chen X. S. , Shen X. , Yin C. M. , Mao Z. Q.
Published: January 2023

Apple replant disease (ARD) caused by the fungal pathogen Fusarium proliferatum f. sp. malus domestica (Fpmd) MR5 brings annual losses to apple production within China. However, the genomic information of the pathogen is not yet available. Here, we obtained the whole-genome sequence of the highly virulent Fpmd MR5 using the Illumina PE150 platform. The genome size was 42.76 Mb and consisted of 9,047 genes. The GC content was 48.80%, and several genes potentially associated with pathogenicity were identified, such as carbohydrate-active enzymes, secreted proteins, and secondary metabolite gene clusters. There were 260 specific virulence factor genes, mainly related to fungal vegetative growth and the production of cell wall-degrading enzymes. These data will aid future studies investigating host–pathogen interactions and help us develop suitable disease management strategies.
Performance Analysis of Directional Ultra-Dense Networks with Dynamic Spectrum Partition Strategy
Authors: Liu Qiaoshou , Gu Yingchen , Wang Jiaxin , Zou Jianwen
Published: January 2023

Intercell interference coordination (ICIC) plays a significant role in strengthening ultra-dense network (UDN) downlink coverage. From a statistical average perspective, a user is primarily interfered by its adjacent base station (BS), especially the second nearest BS. By modeling BSs equipped with directional antennas as a Poisson point process (PPP), this paper proposes a dynamic spectrum resource allocation strategy mainly about users’ service BS and its nearest interference BS, where the subchannel assigned by the typical (served) user is interlaced from the channel simultaneously occupied by users within the effective radiation range of its second nearest BS. To fully explore this scheme for directional networks, we develop analytical expressions in terms of success probability and ergodic rate for the typical user based on the techniques of stochastic geometry, taking into account the fading of directional BS radiation angle. Then, we derive the meta distribution of the signal-to-interference ratio (SIR) for capturing individual link performance changes of users. Simulations verify the correctness of numerical results, and it is revealed that this strategy is in favor of users alleviating interference from their second nearest BSs and the performance advantages of the proposed ICIC strategy are better than those of the traditional directional UDNs.
Investigation on Low Frequency Bandgap of Coupled Double Beam with Quasi-Zero Stiffness for Power Transformer Vibration Control
Authors: He Qiang , Nie Jingkai , Han Yu , Tian Yi , Fan Chao , Dong Guangxu
Published: January 2023

To suppress low frequency vibration and noise generated by power transformer in residential area and achieve environment protection standards, a double-beam metamaterial is proposed, which is fabricated through periodically coupling silicon steel sheet and aluminum beams with Belleville quasi-zero stiffness spring (BQZSS). The double-beam metamaterial can be assembled with iron core of transformers as a whole to obtain the design of a low-noise transformer. Performing static analysis, the mechanical model of BQZSS is established and the relationship between restoring force, stiffness, and displacement can be obtained. Then, the mechanical properties of BQZSS are verified with the finite element method. On this basis, the governing equations of the unit cell of the double-beam metamaterial are derived using Euler–Bernoulli beam theory. According to Bloch theorem and boundary conditions, the dispersion relation of the double-beam metamaterial is deduced, and behaviors of flexural wave propagation in beams are investigated. The effects of structure parameters on bandgaps and dispersion properties are studied, and the low frequency vibration bandgap mechanism is revealed. Finally, the frequency response function (FRF) of the double-beam metamaterial with a finite length is calculated in ANSYS to verify the bandgap characteristics given by a theoretical model. The results show that the double-beam metamaterial can yield multiple low frequency bandgaps at 100 Hz, 200 Hz, 300 Hz, and 500 Hz for suppression of flexural vibration components of transformers, which benefits from Bragg scattering (BS) and the blend of BS and LR mechanisms. The opening and closing of the low frequency bandgaps and the attenuation constants within bandgaps can be tuned by choosing parameters of beams. These findings suggest that the coupling between beams can lead to novel dispersion properties, which provides a new control approach for low frequency vibration and noise in power transformer.
Multichannel Cross-Scale Semantic Coherent Attention Network for Image Inpainting
Authors: Zou Changjun , Ye Lintao
Published: January 2023

This paper investigates a cross-scale space semantic feature coherent image inpainting approach since it is challenging for the existing image inpainting methods to fuse the semantic feature information effectively. Firstly, we learn the feature semantic relevance step-by-step from the high-level semantic feature map’s attention mechanism and then we apply what we have learned to the preceding low-level feature map. In order to preserve the visual and semantic coherence of image repair, the missing content can be filled by changing attention from deep to shallow in a multiscale manner. A broader receptive field is generated by partial convolution, and semantic feature relevance is achieved using a multiscale cross feature space feature attention mechanism based on semantic attention. This technique improves the extensibility and continuity of the restored images by reconstructing the semantic information of different feature spaces, not only taking into account the reuse of existing semantic space features but also including across feature spaces. The experimental results demonstrated an improvement in PSNR, SSIM, and L1 performance by 10.50%, 0.13%, and 47.09%, respectively, with clear benefits.
A Narrative Review on the Role of Technology and Nutrients in Ocular Health
Authors: R. Arivuchudar R. Arivuchudar , Tamilchudar R. , Sendilkumar B.
Published: January 2023

ABSTRACT: Background: The COVID-19 pandemic has led to a revolution in the education sector. The continuous use of gadgets for learning and entertainment has aroused a keen interest in eye health and the role of foods and nutrients in improving eye health. Objective: This study aims to identify and summarize various eye disorders and parameters that are involved in ocular health. Methods: A detailed search of related literature has been carried out with the help of authenticated search engines like Pubmed and Google scholar to review the major deleterious eye problems that persist, and the aetiology of the disorders. Conclusion: Though ocular health is determined by several parameters like socio economic factors, genetic determinants, gender, race, life style and nutrition, diet seems to be a significant lifestyle element that pose to have longstanding effects on ocular health. This study concludes that, it is not an individual nutrient or non-nutrient that impacts eye health, rather a holistic nutritional approach renders more efficacy on vision. It is emphasized that a proper advocacy of foods and nutrients, wise means of technology usage can help to overcome the deleterious effects of deficiencies on eyes.
Assessment and bioremediation of mercury pollutants by highly mercury-resistant bacteria immobilized in biochar from small-scale artisanal gold mining areas
Authors: Rohmah Dewi Nursaidah , Retnaningrum Endah
Published: January 2023

Small-scale gold mining activities in Indonesia still use amalgamation techniques, which have the potential to cause mercury (Hg) pollution and affect the quality and number of microorganisms. Mercury-resistant bacteria can survive and adapt to mercury-exposed environments and can be developed as bioremediation agents. The bioremediation activity of these bacteria can be increased through immobilization using biochar. The results of observations of physicochemical qualities in three samples in the mining area, showed significant differences. The TOC in the rhizosphere soil sample of Calliandra calothyrsus L. showed the significantly highest value at 14.5%, and the pH of the three samples indicated acidity and exhibited no difference (p<0.05). The highest concentration measured in the tailing sample was 9.9 ng/g (p<0.05). The number of heterotrophic bacteria in the rhizosphere soil was the highest at 7.2 × 108 CFU/g. On the other hand, the number of mercury-resistant bacteria in the tailing sample showed the highest value of 6.3 × 103 CFU/g. In the selection based on the toxicity profile of 30 mercury-resistant bacteria obtained, the highest results were observed in the LMP1B5 bacterial isolate from the river sediment, with 50% effective concentration (EC50) and minimum inhibitory concentration (MIC) values of 225 and 250 mg/L, respectively. Polyphasic identification based on phenotypic and genotypic characteristics using the 16S rRNA gene showed that the bacterial isolate was identified as Escherichia fergusonii. The growth and mercury removal activity of E. fergusonii LMP1B5 increased by 21% and 52%, respectively, after the immobilization with biochar. Thus, immobilized E. fergusonii LMP1B5 was effective in removing mercury pollutants.
A McLuhanian Approach to the Typewriter Century
Authors: Tolkačevski Kšištof
Published: January 2023

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‘I feel it's something that irritates her’
Authors: Kirilova Marta , Højland Line
Published: January 2023

Interpreting is increasingly being used in psychotherapy, but the presence of an interpreter in the therapeutic encounter is an under-researched area. This paper examines interpreter-mediated trauma therapy with Danish-speaking therapists treating Arabic-speaking patients diagnosed with post-traumatic stress disorder (PTSD). We focus on the notion of ‘emotion discourse’ as a broad term covering how therapists and patients talk about emotional experience, and how interpreters negotiate and mediate it. The data consist of three group interviews with ten therapists and six excerpts from two audio-recorded interpreter-mediated therapy sessions. The detailed interaction analysis explores (1) the therapists’ expectations about interpreting emotion discourse and (2) the interactional strategies that the interpreters use to negotiate and render the interaction between therapists and patients who speak different languages. The findings show that the therapists have clear expectations about what needs to be translated and how, but these expectations remain hidden to the interpreters. The interpreters use various interpreting strategies and orient towards meaning rather than towards verbatim translations. We conclude by recommending that both therapists and interpreters engage in a professional collaboration that requires not only training and awareness of mutually relevant information, but also an updated view of interpreter-mediated interaction as a dynamic collaborative process.
Agency in endometriosis pain communication in English and Spanish
Authors: Bullo Stella , Pascual Mariana , Magaña Dalia
Published: January 2023

This article interrogates the linguistic construction of agency in accounts of endometriosis pain in English and Spanish. Endometriosis is a reproductive condition causing incapacitating pain which is often dismissed or normalised, leading to delayed diagnosis. We take a patient-centred qualitative approach and analyse data gathered from 10 semi-structured interviews with women with endometriosis in British English and Argentine Spanish, using the transitivity and social actor representation frameworks. The findings indicate that the women across the two settings represent pain as an agentive overpowering actor and themselves with varying degrees of decreased agency. However, pain is more closely related to mental representations of the patients’ experiences in Spanish than in English, where it is construed as an actor performing physical actions. The findings of the study have implications for pain communication practices and cross-language healthcare communication and should inform local pain assessment measures.
Moving books and sensitive readers
Authors: Rydén Gramner Anja
Published: January 2023

Fiction is understood to have unique qualities that emotionally engage the reader, making it suitable as a didactic tool in medical education to help students prepare for the emotional aspects of their future profession. To date, however, little is known about the processes through which talking about fiction, film or poetry can help medical students to co-construct emotional reactions as affective stances and how that might contribute to their professional development. Using a discursive psychology approach, video recordings from 36 fiction seminars collected from 2016 to 2018 were analysed regarding how affective stances related to reading were constructed by medical students. The findings illustrate how students use subject–object relations to account for affective stances, meaning that they attribute their emotional reaction either to an aspect of the book (object-side explanations), or to personal characteristics (subject-side explanations). The way students enact and account for their affective stances can provide opportunities for tutors to create teachable moments for the students. This study contributes to discursive psychology and reader-response research, as well as medical education research.
The new Face(book) of medicine
Authors: Defibaugh Staci , Gut Suzanne M , Weems Elizabeth E
Published: January 2023

Before the COVID-19 pandemic, many medical providers (MPs) turned to social media platforms as an opportunity to interact with colleagues and provide education to patients. When the pandemic flooded social network services (SNSs), such as Facebook, with a great deal of information, both accurate and dubious, MPs continued using SNSs to share information and updates about the infodemic (as defined by the World Health Organization). This study explores how MPs engaged in education and advice giving on Facebook during the early months of the pandemic. For this study, a total of 572 Facebook posts about COVID-19 were collected from the Facebook pages of three medical doctors between 1 January and 15 July, 2020. A total of 79 posts were analyzed, focusing on how advice was discursively constructed. The strategies analyzed included creating a light-hearted tone through moments of levity and making advice more indirect through pronoun shifts and framing devices. We argue that medical providers likely soften the force of advice because of the public/professional confluence that exists on Facebook; this approach may also make the advice more palatable. This study highlights possible implications for current MPs and aid in their overall training.
Trans-Epithelial Photorefractive Keratectomy in the Treatment of Myopia, Hyperopia and Astigmatism: Five-Year Results
Authors: Hasani Hamidreza , Khavandegar Armin , Adhami Parnian , Saberdoust Fateme
Published: January 2023

We aimed to report the five-year results of Trans-epithelial Photorefractive Keratectomy (TPRK) in treating all kinds of refractive errors. In this retrospective cohort study, we quantitatively compared the clinical findings and assessment of optical and refractive parameters, including slit-lamp, corneal topography, Best Corrected Visual Acuity (BCVA), and Uncorrected Distance Visual Acuity (UDVA) in 172 eyes of myopic, hyperopic, and astigmatic patients before and five years after trans-PRK. The average time for post-surgery epithelial healing was 2.97 0.83 days in male and 2.94 0.87 days in female patients; the pain score in a week following the operation was 1.88 0.68 in males and 2.25 0.73 in females. Corneal haze was observed in five patients. No long-term adverse effect was reported. The pre-operative UDVA was 0.84 0.32 in male and 0.87 0.34 in female patients; while the postoperative UDVA was -0.02 0.04 in male and -0.01 0.02 in female patients. There was a highly significant correlation (P<0.001) in all indices except UDVA, which was almost near to being significant (P=0.07). In this survey, the mean safety and index were nearly 1.00. TPRK is a safe and efficient therapeutic procedure to treat all types of refractive errors, including myopia, hyperopia, and astigmatism, with no significant adverse effect. Being touchless and having a short recovery time are two main characteristics of this refractive surgery.
Death Anxiety in the Elderly During the Coronavirus 2019 Pandemic (COVID-19)
Authors: Sheykhangafshe Farzin Bagheri
Published: January 2023

The Article Abstract is not available.
Prevalence of Restless Legs Syndrome and its related Factors among Older Adults in Eslamabad-e-Gharb, Iran
Authors: Morowatisharifabad Mohammad Ali , Bijari Sahar , Madadizadeh Farzan , Bidaki Reza , Beigomi Alireza
Published: January 2023

Introduction: Restless legs syndrome (RLS) is a neurological sensory-motor disorder that is observed as an unpleasant sensation in the legs, especially when sitting or lying down and at rest. This study aimed to determine the prevalence RLS and its related factors among older adults in Eslamabad-e-Gharb, Kermanshah province, Iran in 2021.
 
Methods: Totally, 240 elderlies entered the study using two stages random sampling. The instruments used in the study included the International RLS Questionnaire, Pittsburgh Sleep Quality Index, Mind Wandering Questionnaire, Epworth Sleepiness Scale and Pain Self-efficacy Questionnaire.
 
Results: Symptoms of RLS were mild in 68.3% of the participants and severe in 14.2% of them. There was a statistically significant relationship between RLS and sleep quality (p = 0.001) and daily drowsiness (p = 0.034). The chance of developing RLS in the group with poor sleep quality was 22% higher than the group with good sleep quality (OR = 1.22). Also, people with drowsiness were 13% more likely to develop RLS than others (OR = 1.131), and in the age group of 71-80 years and over 80 years, 6% and 2% higher than the 60-70 years respectively (OR = 1.068 and 1.023). No statistically significant relationship was found between RLS with mind wandering and pain self-efficacy.
 
Conclusion: Due to the high prevalence of RLS and its relationship with sleep quality and daily drowsiness among older adults, implementation of RLS screening to identify patients to prevent sleep disorders seems necessary. The relation of RLS with mind wandering and pain self-efficacy need further studies.
Factors Influencing the Adoption of Mobile Health Monitoring and Care Systems by the Elderly Living at Home in South Africa
Authors: Fotoyi Yolande , Cilliers Liezel
Published: January 2023

Introduction: Technology can improve the health care outcomes of the elderly. However, there are many barriers to the adoption of mobile monitoring and care systems (MMCs) by the elderly reported in literature. The main purpose of this research was to investigate why elderly people do not adopt MMCs to improve the quality of their health care.
 
Methods: The study made use of semi-structured interviews to collect data in the Buffalo City Metropolitan Municipality, South Africa. The study sample consisted of 15 purposively chosen study participants, representing a diverse racial profile, in order to investigate the adoption of MMCs of the elderly in their home environment.  The interviews were analysed thematically.
 
Results: The study found that social challenges like technology anxiety, the intrusive nature of the technology and attitude towards the technology will affect adoption of MMCs. Government need to address the standardisation, data governance and interoperability of the systems. The cost of MMCs were seen as an inhibitor, but could be off set against the perceived return on investment of health care. While the elderly acknowledged that MMCs can improve their independence, the design of the MMCs and training to use it was identified as barriers to the adoption.
 
Conclusion: The study, therefore, recommends collaborative engagements amongst government, business and the elderly to facilitate the adoption of MMCs in the elderly community to improve the quality of health care.
An Investigation into the Surface Dose Using Eclipse Treatment Planning System and Film Dosimetry for Treatment of Breast Cancer
Authors: Sheykholeslami Nooshin , Parwaie Wrya , Farzin Mostafa , Vaezzadeh Vahid , Geraily Ghazale
Published: January 2023

Purpose: Accurate knowledge about surface dose distribution is a critical issue in skin irradiation. This study was conducted to investigate the surface dose using the Eclipse Treatment Planning System (TPS) calculation and GAF chromic film measurement for breast cancer treatment.
Materials and Methods: An inhomogeneous chest phantom was used in the present study. Irradiations were done with a 6 MV energy beam of a linear accelerator (Varian 2100C/D). TPS calculations and film measurements were compared for surface dose estimations.
Results: The average difference between film measurements and TPS calculations was 7.1%. Surface doses were lower in TPS calculations in comparison with film measurements.
Conclusion: TPS plays a significant role in radiotherapy. However, they have many errors in measuring surface doses. Because of the inaccuracy of the majority of treatment planning systems in calculating the surface dose, the need for practical measurements is essential.
Emotion Recognition Using Continuous Wavelet Transform and Ensemble of Convolutional Neural Networks through Transfer Learning from Electroencephalogram Signal
Authors: Bagherzadeh Sara , Maghooli Keivan , Shalbaf Ahmad , Maghsoudi Arash
Published: January 2023

Purpose: Emotions are integral brain states that can influence our behavior, decision-making, and functions. Electroencephalogram (EEG) is an appropriate modality for emotion recognition since it has high temporal resolution and is a non-invasive and cheap technique.
Materials and Methods: A novel approach based on Ensemble pre-trained Convolutional Neural Networks (ECNNs) is proposed to recognize four emotional classes from EEG channels of individuals watching music video clips. First, scalograms are built from one-dimensional EEG signals by applying the Continuous Wavelet Transform (CWT) method. Then, these images are used to re-train five CNNs: AlexNet, VGG-19, Inception-v1, ResNet-18, and Inception-v3. Then, the majority voting method is applied to make the final decision about emotional classes. The 10-fold cross-validation method is used to evaluate the performance of the proposed method on EEG signals of 32 subjects from the DEAP database.
Results:.The experiments showed that applying the proposed ensemble approach in combinations of scalograms of frontal and parietal regions improved results. The best accuracy, sensitivity, precision, and F-score to recognize four emotional states achieved 96.90% ± 0.52, 97.30 ± 0.55, 96.97 ± 0.62, and 96.74 ± 0.56, respectively.
Conclusion: So, the newly proposed model from EEG signals improves recognition of the four emotional states in the DEAP database.
Identification of New Potential Allergens from Green-lipped Mussel (Perna Canaliculus)
Authors: Kage Paula , Schubert Kristin , Treudler Regina , Simon Jan-Christoph , Bergen Martin von , Tomm Janina
Published: January 2023

The green-lipped mussel (Perna canaliculus) originates from New Zealand. To preserve the health benefits of green-lipped mussel meat, it is freeze-dried to make a long-lasting powder. The powder is used to treat arthritis because of its potential anti-inflammatory properties. The report describes a 54-year-old woman who developed immediate rhinoconjunctival and respiratory symptoms after inhaling green-lipped mussel powder she gave to her dog for arthritis.
A skin prick test with green-lipped mussel powder was performed. Protein extracts from P canaliculus were separated by sodium dodecyl–sulfate polyacrylamide (SDS) gel electrophoresis and probed with serum from patients and serum preincubated with green-lipped mussel extract. Bound immunoglobulin E (IgE) was detected by specific anti-human-IgE antibodies, and IgE-binding proteins were subsequently identified by liquid chromatography and mass spectrometry.
The skin prick test was positive for green-lipped mussel. Specific IgE against green-lipped mussel extract was detected using Western immunoblotting. These potential allergenic proteins were identified by mass spectrometry as actin, tropomyosin, and paramyosin.
All three allergens are reported for the first time for P canaliculus. Actin is a major allergen in Paphia textile, paramyosin in Sarcoptes scarbiei, and tropomyosin in Haliotis discus. For all IgE-binding proteins, the software AllCatPro predicted high allergenicity, supporting our conclusion that these proteins from P canaliculus may also be allergenic. The identification of allergens from P canaliculus provides the opportunity for specific tests to assess the frequency of allergic reactions to P canaliculus.
Evaluación de modelos SonReb para la estimación de la resistencia a compresión en hormigones de cemento y áridos cubanos
Authors: Hernández Oroza Alberto , Cuetara Ricardo Joaquín R.
Published: January 2023

El estudio realizado tuvo como objetivo evaluar diferentes modelos SonReb para estimar la resistencia a compresión en elementos de hormigón armado fabricados con cemento y áridos cubanos. Se realizaron mediciones de índice esclerométrico y velocidad del pulso ultrasónico en 9 columnas diseñadas con mezcla de cemento Portland ordinario P-35. Se compararon 8 modelos, de los cuales los propuestos por RILEM y Tanigawa et al. mostraron un error inferior al 4% con respecto al valor de referencia, determinado mediante rotura de probeta. Los resultados obtenidos demuestran la factibilidad de uso de los modelos para la estimación de resistencia a compresión del hormigón, empleando materiales nacionales.
Desempeño de la adición de ceniza de bagazo de caña como filler para producir concretos autocompactantes
Authors: Estrada Jesús Alexander , López González Alexander , Hernández Cruz Daniel , Mandujano Zavala Josseph Elí , Cabrera Madrid Jesús Alejandro
Published: January 2023

Se evaluó el desempeño de la influencia de la ceniza de bagazo de caña (CBC) como filler en mezclas de concreto autocompactante (CAC), adicionado en un 0%, 5%, 10%, 15%, 20% y 25% con respecto al peso de cemento. La caracterización de la ceniza se realizó mediante FTIR, FRX y DRX. Las propiedades de trabajabilidad del CAC fueron determinadas mediante ensayos de flujo de asentamiento, anillo J, caja en L, embudo V, Índice de Estabilidad Visual y resistencia a la compresión. De acuerdo con los resultados, los porcentajes de 10 al 20% en las mezclas de CAC obtuvieron un desempeño satisfactorio, evidenciando parámetros de trabajabilidad y resistencia a la compresión sobresalientes comparados con trabajos similares a los publicados en la literatura.
Factors Affecting Profit Persistence
Authors: Khoirunnisa’ Fibrianti , Maryanti Eny
Published: January 2023

This study aims to determine the factors that influence earnings persistence in G0-Public BUMN companies listed on the Indonesian stock exchange for the 2017-2019 period. This study uses quantitative research with secondary data as a data source. The population of this study is the G0-Public BUMN companies listed on the Indonesia Stock Exchange for the 2017-2019 period, totaling 20 companies. Based on purposive sampling criteria obtained 16 companies that meet the research criteria. This study uses data analysis testing software SPSS (Statistical Package for Social Science) version 23. The results showed that operating cash flow, debt level, firm size, cash flow volatility, sales volatility had an effect on earnings persistence. Highlights: Earnings persistence in G0-Public BUMN companies: This study focuses on understanding the factors that influence the stability and consistency of earnings in government-owned public companies listed on the Indonesian stock exchange. Factors affecting earnings persistence: The study identifies several key factors that have an impact on earnings persistence, including operating cash flow, debt level, firm size, cash flow volatility, and sales volatility. Quantitative research and data analysis: The study adopts a quantitative research approach using secondary data obtained from the Indonesian stock exchange. Data analysis is performed using SPSS software to determine the relationships between the identified factors and earnings persistence. Keywords: earnings persistence, G0-Public BUMN companies, Indonesian stock exchange, quantitative research, SPSS.
Relationship Between Narcissistic Tendencies and Social Media Addiction in Instagram Using Student University
Authors: Widiyanti Wenny , Widyastuti
Published: January 2023

This quantitative research study investigates the presence of narcissistic tendencies and their association with social media addiction in students using Instagram at Muhammadiyah University of Sidoarjo. With a sample size of 300 students selected through quota sampling technique, the study employed the Berge Social Media Addiction Scale (BSMAS) and Narcissistic Personality Inventory (NPI) scale for data collection. Utilizing Pearson's product-moment correlation analysis in SPSS, the findings reveal a significant positive relationship between narcissistic tendencies and social media addiction (rxy = 0.125, p = 0.031 < 0.05). The study's implications suggest that approximately 2.3% of social media addiction can be attributed to narcissistic tendencies among university students. These results contribute to a deeper understanding of the interplay between personality traits and online behavior, urging further research and interventions to address the impact of narcissism on social media engagement. Highlights: The study explores the relationship between narcissistic tendencies and social media addiction among university students on Instagram. The research utilizes quantitative methods and correlational analysis to examine the association between narcissistic tendencies and social media addiction. Findings reveal a significant positive relationship between narcissistic tendencies and social media addiction among students, highlighting the influence of personality traits on online behavior. Keywords: narcissistic tendency, social media addiction, university students, Instagram, correlation
Relationship of Secure Attachment to Fathers and Mothers with Emotional Intelligence in Junior High School Adolescents
Authors: Yanti Rachma Aulia Prima , Mariyati Lely Ika
Published: January 2023

This study was conducted with the aim of revealing whether or not there is a relationship between secure attachment to fathers and mothers with emotional intelligence in adolescents at SMP Negeri 2 Sedati. The research method used is correlational quantitative. The variables in this study are secure attachment to the father and secure attachment to the mother as the independent variable and emotional intelligence in adolescents as the dependent or dependent variable. This research was conducted at SMP Negeri 2 Sedati with 198 students as the sample using proportionate stratified random sampling technique. Data analysis was performed by multiple regression correlation analysis using the JASP 0.14.1.0 program. based on the results of data analysis showed a positive relationship between secure attachment to father and mother with emotional intelligence with an F value of 73,958 and a significance of p < 0.001 which means that the hypothesis in this study can be accepted with an effective contribution of 43.1% which indicates that secure attachment to father and mother effect on adolescent emotional intelligence.
Metabolic effects of the liraglutide: a discussion of the results of clinical observations
Authors: Reznikov E. A. , Babaeva E. A. , Vidiker R. V.
Published: January 2023

Objective: to discuss the features of the use of the drug liraglutide for the treatment of patients with obesity, to analyze the metabolic parameters dynamic and the difficulties that arise during therapy, based on our own clinical observations.Materials and methods: the article provides an analysis of our own clinical observations of patients aged 54 and 47 years who received liraglutide therapy for exgenous constitutional obesity of the II degree. According to the examination results, both patients showed hyperinsulinemia and insulin resistance signs, lipid metabolism disorders. There were no episodes of acute pancreatitis in the past. Heredity for medullary thyroid cancer is not burdened, thyroid status is normal. Dose liraglutide escalation is recommended on a schedule 0.6 mg per week.Results: during therapy with liraglutide, patients under observation experienced a gradual progressive decrease in body weight against the background of a decrease in appetite and a decrease in the amount of food consumed. In the dynamics, there was a tendency to normalize the initial metabolic disorders: a decrease in insulin resistance and hyperinsulinemia, carbohydrate metabolismdisorders and lipid profile.Conclusion: the results of our own clinical observations indicate the effectiveness of the drug liraglutide use in the treatment of patients with obesity, not only to achieve the target weight loss indicators, but also to correct the initial disorders of the metabolic status.
Some issues of the quality of medical care
Authors: Volkova N. I. , Volkov A. V.
Published: January 2023

This article discusses the features of applying the theory of quality to medical science and practice. The methods of analytical medicine show the internal contradiction of the existing theory of diagnostics as a source of medical errors. Approaches to resolving this paradox are given.
White-coat hypertension in pregnant women
Authors: Chulkov V. S. , Nikolenko E. S. , Chulkov Vl. S.
Published: January 2023

Hypertensive disorders during pregnancy remain a global medical and social problem, complicating 2–8% of pregnancies and associated with high maternal and perinatal morbidity and mortality. The traditional measurement of blood pressure in clinical practice is the most commonly used procedure for the diagnosis and control of the treatment of hypertension, but it is subject to significant inaccuracies caused, on the one hand, by the inherent variability of blood pressure itself (BP), and on the other hand, by errors arising from measurement methods and conditions. A high BP detected in the clinic should be confirmed by out-of-office BP measurement, 24-hour ambulatory BP monitoring, or home BP monitoring, which distinguishes chronic hypertension from white coat hypertension, in which blood pressure is elevated in the clinic, but remains normal at home, which is important to prevent excessive treatment and diagnosis of masked hypertension. White-coat hypertension is not a benign condition in which higher risks of developing preeclampsia, premature birth and small-for-gestational-age infants have been shown. In this regard, it is extremely important for clinicians to be aware of the risk factors and outcomes associated with white coat hypertension. Pregnant women should be medically monitored both during pregnancy and after delivery to detect target organ damage, cardiovascular risk factors and metabolic syndrome.
The relationship of fibroblast growth factor 23 with calcification of the thoracic aorta according to the results of multislice computed tomography in patients with resistant arterial hypertension
Authors: Litvinova M. S. , Khaisheva L. A. , Shlyk S. V.
Published: January 2023

Objective: to evaluate the incidence and severity of thoracic aortic calcification, the relationship with endothelial dysfunction and fibroblast growth factor in patients with resistant arterial hypertension.Materials and methods: the study involved 92 patients with resistant hypertension. Daily monitoring of blood pressure (ABPM) was performed, the functional state of the endothelium was assessed in a sample with reactive hyperemia, the calcium index (CI) of the thoracic aorta was determined using MSCT, and the serum level of FGF-23 was determined using enzyme immunoassay.Results: based on ABPM, patients were divided into groups 1st-controlled (n=44) and 2nd-uncontrolled (n=48) resistant AH. In the 2nd group, a more pronounced dysfunction of the endothelium was revealed in the sample with reactive hyperemia and changes in the velocity parameters of blood flow. FGF23 levels and CI were higher in individuals with uncontrolled resistant hypertension. According to the results of correlation-regression analysis, CI was associated with the value of pulse pressure (r=0.49, p=0.007), the duration of hypertension (r=0.68, p=0.04) and the duration of regular antihypertensive therapy (r = −0 .33, p=0.02). FGF- 23 was found to be associated with PA hemodynamic parameters: with Ved (r=0.42, p=0.003), PI (r=0.43, p=0.041) and RI (r=0.46, p=0.025), as well as with CI (r=0.76, p=0.006).Conclusion: patients with uncontrolled resistant hypertension showed a more pronounced decrease in brachial artery EVR and an increase in vascular resistance indices in the test with reactive hyperemia, which was statistically significantly associated with the level of FGF23. In patients with resistant hypertension, excessive calcification of the thoracic aorta was found according to the results of MSCT. Calcium index values are higher in patients with high pulse BP, longer duration of hypertension and high levels of FGF23.
Clinical and biochemical characteristics of patients with chronic heart failure depending on the variant of polypharmacy
Authors: Tarlovskaya E. I. , Omarova Y. V.
Published: January 2023

Objective: to study the features of the clinical course of chronic heart failure (CHF) and laboratory and biochemical characteristics of patients, depending on the variant of polypharmacy.Materials and methods: the study included 73 patients with CHF aged 74.58±10.05 years. Venous blood was taken from all patients on the 1st day of hospitalization in order to determine the levels of NT-proBNP, sST2, NGAL, cystatin C. Patients were divided into groups depending on the type of polypharmacy (corresponding and inappropriate) according to the criteria of the EURO-FORTA system (2018) and on based on national clinical guidelines.Results: depending on the type of polypharmacy at the outpatient stage, according to the EURO-FORTA criteria (2018), 2 groups of patients were distinguished: 1st (corresponding) — 47.94% of patients; 2nd (inappropriate) — 52.06%; based on national clinical guidelines: group 1 (corresponding) — 53.42% and group 2 (inappropriate) — 46.58%. When evaluating polypharmacy according to the EURO-FORTA criteria, patients of the 2nd group more often had joint diseases (p=0.035), acute kidney injury (AKI) according to baseline creatinine (47.37% vs. 20%; p=0.014) and 4 times more often than patients of the 1st group were hospitalized due to atrial fibrillation (AF) (p=0.048). When dividing patients based on national clinical guidelines into groups of appropriate (1) and inappropriate (2) polypharmacy, it was found that in group 2, compared to group 1, there were more patients with joint diseases (44.12% versus 15.38%; p=0.007), anemia of 1–2 degrees (67.65% vs. 35.90%; p=0.025) and CKD of 3–5 stages (76.47% vs. 53.85%; p=0.044), more often observed OPP (p=0.008).Conclusion: a comparative analysis of the clinical and laboratory status of patients with appropriate and inappropriate polypharmacy revealed that the main difference between patients with inappropriate polypharmacy is more pronounced renal dysfunction and the prevalence of anemia, as well as a higher rate of hospitalization with paroxysmal AF/AFL. The division of patients into groups of appropriate and inappropriate polypharmacy based on clinical recommendations does not require additional evaluation using the EURO-FORTA system.
Clinical efficacy of a method for identifying patients at high risk of carotid atherosclerosis in rheumatoid arthritis
Authors: Eliseyeva L. N. , Otarova ZH. Z. , Zhdamarova O. I. , Davydova A. F.
Published: January 2023

Objective: to test the patented “Method for determining a high risk of atherosclerosis in rheumatoid arthritis” on patients with rheumatoid arthritis.Materials and methods: 74 patients with RA who underwent inpatient treatment were examined. Gender composition of respondents: 77% women and 23% men. Mean age 54.1±9.1 years. The duration of RA is from 1 year to 26 years. 85.1% were diagnosed with a high degree of disease activity. Erosive arthritis was detected radiographically in 41 patients (55.4%). 83.7% (n=62) were seropositive for RF, 81% for ACCP (n=60). All received basic anti-inflammatory therapy. Systemic glucocorticoid therapy was received by 33.7%. All patients were calculated cardiovascular risk according to SCORЕ and mSCORЕ Also, all patients underwent duplex scanning of the BCA to detect atherosclerosis.Results: no significant increase in traditional factors of cardiovascular diseases was found among patients. When CVR was stratified according to SCORE, the frequency of low risk was 32.4%, moderate — 59.5%, high — 5.4%, very high — 2.7%. When using mSCORE, low risk was found in 27%, moderate — 56.7%, high — 13.5%, very high — 2.7%. Atherosclerotic plaques (ASP) in the carotid arteries in patients stratified according to SCORE for moderate, high and very high risk was detected in 68%, in persons with similar risks according to mSCORE — in 66.7%. With a score of 4 or more when using the tested method, ASP was found in 77.8%. Sensitivity for the detection of ASP in the carotid arteries using SCORE was 0.77, with mSCORE and the tested method 0.81 and 0.95, respectively. Specificity 0.47, 0.4 and 0.6 respectively. Positive predictive power for SCORE — 0.68, mSCORE — 0.67, tested method — 0.77. Negative predictive power for SCORE — 0.58, mSCORE — 0.6, tested method — 0.9.Conclusion: the study showed that our proposed method, which uses traditional clinical markers, significantly increases the sensitivity, specificity, and negative predictive power of calculation methods for identifying a group of individuals with a high risk of atherosclerotic lesions of extracranial arteries against the background of rheumatoid arthritis compared with using the SCORE and mSCORE parameters.
Levosimendan protects against ischemia – reperfusion injury in the human heart muscle. A pilot study
Authors: Kunecki Marcin , Oleksy Tomasz , Nozynski Jerzy , Podolec Piotr , Biernat Jolanta , Deja Marek Andrzej , Golba Krzysztof Stanislaw , Plazak Wojciech
Published: January 2023

The consequences of myocardial infarction (MI) are an increasing problem worldwide. Despite spectacular progress in the invasive treatment of ischemic heart disease, the ability to limit the ischemia-reperfusion (I/R) injury remains largely unrealized. Recent studies have shown that stimulation of opioid receptors may confer a cardioprotective effect against I/R injury. Levosimendan, the inodilator, is indicated for the short-term treatment of acutely decompensated heart failure. We tested the hypothesis that levosimendan may provide cardioprotection in the opioid-like mechanism in the human myocardium.