bluuebunny/crossref_metadata_2025 huggingface dataset:
A case series of interesting mucocutaneous presentations in COVID-19 infection or post COVID-19 vaccination confirmed by biopsy and histopathologic assessment
Authors: Mohammad Arash Pour , Noroozi Elahe , Mesgarha Milad Gholizadeh , Shayanfar Nasrin , Goodarzi Azadeh
Published: February 2023

Mucocutaneous complications or adverse events due to SARS-CoV-2
infection or vaccination have been well-delineated in the literature,
respectively. Most eruptions are considered to be mild and
self-limiting; however, for the atypical cases which have a tentative
clinical diagnosis, performing a biopsy and histopathological assessment
is pivotal to confirm the diagnosis and subsequently prescribe a more
tailored treatment. Despite the diverse reporting of such incidents
globally, the rate of biopsied cases is restricted to less than 15% in
most studies.    This case series elucidates 20 patients referred to the
tertiary dermatology clinic, including 14 COVID-19 infection-related
eruptions such as Lichen Planus (LP), Cutaneous vasculitis, Pityriasis
rosea (PR), Discoid lupus erythematosus, Guttate psoriasis, Sarcoidosis,
Raynaud’s phenomenon, non-specific lesions resembling genital warts,
Beau’s line and one severe case of purpura fulminans with a promising
outcome. Moreover, we presented 6 vaccine-induced cases comprising LP,
Urticarial vasculitis, PR, Parapsoriasis, and Localized Morphea. The
diagnosis of all cases has been proven by histopathological evaluation.
We included pertaining anamnesis details of each patient together with
vivid classifying images to pinpoint the morphologic features of each
condition.   In line with our previous studies, the vaccine-induced
eruptions were less severe compared to infection-related complications
of COVID-19 and are mostly controllable by antihistamines and
corticosteroids administration. Therefore, reporting such events should
not hinder COVID-19 vaccination in the general population.
APATHY & COGNITIVE SYMTOMS
Authors: Polat Selim , Erdem Miray , Çekinmez Melih
Published: February 2023

Objective: The aim of this research was to elucidate the effect of deep
brain stimulation on apathy, and cognitive functions in the pre and
post-operative period. Materials & Methods: This study was conducted in
Adana City Training & Research Hospital, Parkinson and Movement
Disorders Center between January to December 2022. Individuals were
evaluated by a multidisciplinary commission consisting of neurology,
neurosurgery and psychiatrists. Thirty six, aged between 18–70 years
who underwent Deep Brain Stimulation at the neurosurgery clinic were
included in the study. Hamiltonanxiety and depression, apathy
assessment, standard mini-mental test and Montreal Cognitive Assessment
scales are applied to the patients. Results: The mean Apathy Score at
the pre-op was 47.77±15.83 in patients who had undergone DBS operation
while it was 30.83±13.59 in the post–op. This decrease was
statistically significant (p<0.003) and indicated clinical
improvement. The average Hamilton Anxiety scale scores at the pre–op
was 11.50±5.14, and s 10.22±5.57 at the post-op with no clinical
significance (p=0.28). The UPDRS-ON value was determined as 22.55±7.53
in the pre–op and 14.50±6.99 in the post–op significantly
(p<0.001). UPDRS-OFF was found to be significant with pre–op
37.44±9.85, compared to post–op 23.44±7.86 (p<0.001).
Conclusion: Regarding the results of this study, it was found that sub
– thalamic stimulation led to stabilization of both motor and non-motor
complications. Additionally DBS ameliorated apathy and Parkinson’s
Disease symptoms of patients significantly. Future studies with larger
sample size that focus on both pharmacological and non-pharmacological
treatments might provide better clinical aspects.
Dynamic model inference of gene regulatory network based on hybrid parallel genetic algorithm and threshold qualification method
Authors: Ding Huaibao , Ding Xiaomei , Zhou Fei
Published: February 2023

Gene regulation is the regulation of gene expression behavior by various
related substances in cells, which controls almost all cell activities.
Therefore, the study of gene regulation can not only explore the
internal law of life activities, but also play a great role in the
prediction, diagnosis, treatment and drug design of gene-related
diseases. Using multi-source biological information such as gene
expression profile data, transcription factor information and protein
interaction information, a network model can be established to describe
the regulatory relationship between genes, so as to facilitate the above
studies. In order to solve the problem of low accuracy of traditional
gene regulatory network construction methods, a new dynamic model of
gene regulatory network was established by combining hybrid genetics and
threshold restriction. The model is divided into two parts: solution
space reduction and parameter fitting. In the phase of solution space
reduction, singular value decomposition method is used to define the
mathematically feasible gene regulatory network to reduce unnecessary
calculation, and then the control gene of each gene is limited to a
certain scale by threshold limitation method, which improves the
computational efficiency and accords with the bioinformatics rules. In
the parameter fitting part, the parallel genetic algorithm is used to
optimize the whole solution space quickly, and then the mountain
climbing method is used to solve the problem carefully in a small range
to improve the calculation accuracy. In this study, we applied this
method to the establishment of genetic regulatory systems for complex
skin melanoma and type 2 diabetes. By comparing with the real network,
the correctness of the method is proved. Compared with traditional
genetic and PSO methods, the effectiveness of the proposed method was
verified. In this paper, the deep mechanism of gene regulation is
modeled, and the regulation process involving genes, proteins and small
biological molecules is described in more detail, so as to be more
detailed than other models and more consistent with the intracellular
dynamics law.
Investigating the effects of antibiotic use during the influenza epidemic on the hospital industry in Iran and the world
Authors: Shafie Seyed , nasiri taha , jamshidi vahdat
Published: February 2023

Influenza is an infectious disease caused by a type of Arani virus that
enters the lungs and causes an acute infection of the respiratory tract.
The Spanish flu pandemic in 1918 killed about 40 to 50 million people
worldwide. In Iran, influenza is an endemic disease and cases of
infection and death of this disease are registered in the country every
year. Antibiotics are unnecessary costs in the initial treatment of
influenza, because they can have potential side effects and spread
resistant bacteria. Antibiotics help. From an economic point of view,
the cost of antibiotic treatment in the hospital in 2000 was estimated
at about 40 billion dollars, of which the share of developing countries
was about one third. In 1990, the percentage of antibiotic sales of all
medicines worldwide was 12%, of which the share of developing countries
was 19%, while in 2000, this figure reached 34%. Therefore, the growth
of the cost of antibiotics, especially in developing countries, has
continued despite the efforts made to limit the unnecessary use of
antibiotics. It is important to identify the cause of the disease in the
first stage and choose the right and scientific method of treatment in
the next stage; And if it is necessary to use antibiotics, first
identify the type of bacteria, because the selection of antibiotics
based on its results plays a very important role in the successful
treatment of infections, proper sampling before starting the use of the
first antibiotic is also important. .
Influences of surface runoff detachment and sediment transport on insoluble nitrogen and phosphorus loss under two planting methods with Prunella vulgaris
Authors: Wang Dongdong
Published: February 2023

A lack of research on sediment displacement has led to a corresponding
lack of understanding regarding the movement of insoluble N and P. In
this study, we used field simulated rainfall experiments and discovered
the following: first, the regulatory effects of the two planting methods
on the runoff detachment rate was greater than that on the runoff
sediment transport rate, and the influence of rainfall intensity was
greater than that of slope. Outside the threshold, the regulatory
effects of the two planting methods on runoff detachment and sediment
transport on different slope gradients were diametrically opposed.
Second, N loss was 10 times higher than P loss during rainfall events. N
and P losses were highest on bare slopes, and lowest on slopes on which
the Prunella vulgaris combined with earthworms planting method
was used. N and P loss during rainfall events increased as rainfall
intensity increased, and decreased as slope increased. The rate of
change increased under high rainfall intensity or slope gradient. Third,
regulation of insoluble N loss under the P. vulgaris-only
planting method was achieved through regulation of runoff detachment and
sediment transport, with contribution rates of 23.89% and 31.98%,
respectively. Regulation of insoluble N loss under the P.vulgaris
combined with earthworms planting method was achieved by regulating
runoff detachment, with a contribution rate of 66.92%. Regulation of
insoluble P loss under the two planting methods was achieved by
regulating both the runoff detachment and sediment transport rates.
Hepatocyte nuclear factor 4α multiple isoforms, their functions, and their interactomes
Authors: Herrera-Pulido Jehison , Boisvert Francois-Michel , Boudreau Francois
Published: February 2023

HNF4α is a master regulator gene belonging to the nuclear receptor
superfamily involved in regulating a wide range of critical biological
processes in different organs. Structurally, the HNF4A locus is
organized with two independent promoters and is subjected to alternative
splicing with the production of twelve distinct isoforms. Little is
known about the mechanisms each isoform uses to regulate transcription
and their biological impact, with some reports addressing these aspects.
Proteomic analyses have led to identifying proteins that interact with
specific HNF4α isoforms. The identification and validation of these
interactions and their role in co-regulating targeted gene expression
are essential to understand better the role of this transcription factor
in different biological processes and pathologies. This review addresses
the historical origin of HNF4α isoforms, some of the main functions of
the P1 and P2 isoform subgroups and provide information on the most
recent hot topic research on the nature and function of proteins
associated with each of the isoforms in some biological contexts.
How to Become An Excellent Cardiovascular Scholar & Researcher?
Authors: Hu Chunsong
Published: February 2023

What should be encouraged to develop the scientific competence of
scholars and researchers (S&R)? What should a scientific evaluation
focus on? These are important topics in medical education. In fact,
there are several core competencies that should be encouraged, including
learning, research, scientific writing, innovation and translational
applications. Scientific evaluation should pay attention to several
“hard indicators”, including academic leadership, independence,
guidance, diversity, cooperation and innovation. But how to become an
excellent cardiovascular S&R, it is necessary to continuously improve
the scientific ability and levels, including innovation and publishing
academic papers as the first or single author in one of the “345” top
international journals. Since these key indicators are vital markers, it
is time to develop a new scoring system to better and more rationally
evaluate one’s scientific performance. In addition, there is a need for
more innovative, value-added courses and hands-on experience to greatly
improve their academic level.
Variation in patient presentation and the use of computer tomography in the urgent care diagnosis and treatment of peritonsillar abscess
Authors: Bell Christopher , Chau Justin
Published: February 2023

Background A peritonsillar abscess (PTA) is a collection of infectious
material within the peritonsillar space, seen most often in teenagers
and young adults. The diagnosis of a PTA is reliant on a patient’s
history and physical exam; however, CT scans continue to be used. The
rationale for imaging in the diagnosis of a PTA may be better understood
based on patient presenting symptoms and physical exam findings. Methods
A retrospective review of adult patients diagnosed with a peritonsillar
abscess in an acute care/emergency setting at a tertiary hospital
between January 1 to December 31, 2019, was performed. Patients were
arranged into two groups: those who underwent a CT scan versus patients
who did not scan as part of their clinical work-up. Patient
demographics, and differences in the rate of subjective and objective
findings were compared. Results 43 patients were included in the study:
19 in the CT scan group, and 23 in the no-CT scan group. There was no
statistically significant difference in the history of previous
peritonsillar abscess incidence, patient chief complaint at triage,
subjective complaints, or objective physical exam findings. The most
common patient reported symptoms in both groups were odynophagia and
dysphagia. The most common objective findings in both groups included
peritonsillar fullness and erythema, and uvular deviation. Conclusion
Patients who underwent a CT scan as part of their work-up for a
peritonsillar abscess had no difference in symptoms or physical exam
findings when compared to patients who did not have a CT scan.
Highly exothermic process characteristics of catalytic reactors with integral heat exchange structures
Authors: Chen Junjie
Published: February 2023

In modern industrial practice, a variety of highly exothermic reactions
are promoted by contacting of the reaction mixture in the gaseous or
vapor phase with a heterogeneous catalyst. A need exists for improved
catalytic structures employing integral heat exchange which will
substantially widen the window or range of operating conditions under
which such catalytic structures can be employed in highly exothermic
processes like catalytic combustion or partial combustion. The highly
exothermic process characteristics of catalytic reactors are
investigated with integral heat exchange structures. Ethane mole
fraction and gas-phase reaction rate profiles in catalytic reactors are
presented, and ethane mole fraction, flow velocity, gas-phase reaction
rate, and temperature contour plots are illustrated for catalytically
supported thermal combustion systems. The present study aims to provide
an improved reaction system and process for combustion of a fuel wherein
catalytic combustion using a catalyst structure employing integral heat
exchange affords a partially-combusted, gaseous product which is passed
to a homogeneous combustion zone where complete combustion is promoted
by means of a flame holder. Particular emphasis is placed upon the
catalytic reactor configuration that allows the oxidation catalyst to be
backside cooled by any fluid passing through the cooling conduits. The
results indicate that the percentage of reaction completed in the
exothermic catalytic reaction channel depends both upon the flow rate of
the fuel-oxidant mixture through the exothermic catalytic reaction
channel and upon the physical characteristics of the catalytic reactor.
The tortuosity of the catalytic channels is increased by changing their
cross-sectional area at a multiplicity of points along their
longitudinal axes. The gas flow velocity entering the exothermic
catalytic reaction channel should exceed the minimum required to prevent
flashback into the fuel-oxidant stream upstream of the reactor if the
fuel-oxidant mixture entering the exothermic catalytic reaction channel
is within the limits of flammability. Catalytically-supported thermal
combustion in the catalytic reactor is achieved by contacting at least a
portion of the carbonaceous fuel intimately admixed with air with a
solid oxidation catalyst having an operating temperature substantially
above the instantaneous auto-ignition temperature of the fuel-air
admixture. The film heat transfer coefficient provides useful means of
characterizing the different flow geometries provided by the various
flow channel configurations which distinguish the catalyst-coated
channels from the catalyst-free channels of the catalyst structure. The
total residence time in the combustion system should be sufficient to
provide essentially complete combustion of the fuel, but not so long as
to result in the formation of oxides of nitrogen.

Keywords: Catalytic reactors; Physical characteristics;
Exothermic reactions; Heterogeneous catalysts; High temperatures;
Thermal combustion
Dynamic Rupture Scenarios of the Cascadia Megathrust based on Interseismic Locking Models
Authors: Chan Yuk Po Bowie , Yao Suli , Yang Hongfeng
Published: February 2023

The Cascadia subduction zone in the Pacific Northwest has
well-documented geological records of megathrust earthquakes with the
most recent Mw 9 rupture occurring in 1700 A.D. The paleoseismic
observations suggest that Southern Cascadia is mature for future
earthquakes since the last event. Consequently, it is crucial to
investigate the potential rupture scenarios. Various interseismic
locking models are developed along Cascadia, including offshore
uncertainties and different material assumptions. Although they all
share similar moment deficits, whether future earthquakes may rupture
the entire margin or be segmented, as found in the paleoseismic records,
remains unknown. Accordingly, we aim to investigate: (1) possible
rupture segmentation patterns, (2) whether south Cascadia can host
margin-wide ruptures, and (3) whether the existing locking models
suggest similar future rupture scenarios. We estimate the stress
distribution constrained by the locking models from static calculation
and discover that they lead to different stress distributions,
indicating distinct seismic potentials despite their similar moment
deficits. Our dynamic rupture scenarios show that the south can generate
both segmented ruptures (> Mw 7.3 - 8.4) and margin-wide
ruptures (> Mw 8.6) depending on hypocenter locations. The
extent of Schmalzle-based segmented scenarios matches the proposed
historical segmented events, and the margin-wide scenarios are well
consistent with the coastal subsidence records of 1700 A.D. Therefore,
we propose that three high-slip trench-breaching patches are sufficient
for reproducing historical subsidence records. Our reasonable dynamic
simulations can be applied in future studies for assessing seismic and
tsunami hazards, and also serve as a comparison for non-trench-breaching
scenarios.
Seasonal Variations of Soil Thermal Conductivity at the InSight Landing Site
Authors: Grott Matthias , Piqueux Sylvain , Spohn Tilman , Knollenberg Joerg , Krause Christian , Marteau Eloise , Hudson Troy L. , Forget Francois , Lange Lucas , Müller N. , Golombek Matthew P. , Nagihara Seiichi , Morgan Paul , Murphy J.P. , Siegler Matthew Adam , King Scott D. , Banfield Donald , Smrekar Suzanne E , Banerdt William Bruce
Published: February 2023

The heat flow and physical properties package measured soil thermal
conductivity at the landing site in the 0.03 to 0.37 m depth range. Six
measurements spanning solar longitudes from
8.0$^\circ$ to 210.0$^\circ$
were made and atmospheric pressure at the site was simultaneously
measured using InSight’s Pressure Sensor. We find that soil thermal
conductivity strongly correlates with atmospheric pressure. This trend
is compatible with predictions of the pressure dependence of thermal
conductivity for unconsolidated soils under martian atmospheric
conditions, indicating that heat transport through the pore filling gas
is a major contributor to the total heat transport. This implies that
any cementation or induration of the soil sampled by the experiments
must be minimal and that the soil surrounding the mole at depths below
the duricrust is unconsolidated. Thermal conductivity data presented
here are the first direct evidence that the atmosphere interacts with
the top most meter of material on Mars.
Totally umbilical semi-invariant submanifolds in locally decomposable metallic Riemannian manifolds
Authors: Gök Mustafa , Kılıç Erol
Published: February 2023

In this paper, we obtain some classification theorems for totally umbilical
semi-invariant submanifolds in locally decomposable metallic Riemannian
manifolds. We also prove that there exist no totally umbilical proper
semi-invariant submanifolds in a posivitely or negatively curved locally
decomposable metallic Riemannian manifold
An investigation of incomplete H−functions associated with some fractional integral operators
Authors: Harjule Priyanka , Bansal Manish , Araci Serkan
Published: February 2023

Arbitrary-order integral operators find variety of implementations in different science disciplines as well as engineering fields. The study presented as part of this research paper derives motivation from the fact that applications of fractional operators and special functions demonstrate a huge potential in understanding many of physical phenomena. Study and investigation of a fractional integral operator containing an incomplete H? functions (IHFs) as the kernel is the primary objective of the research work presented here. Specifically, few interesting relations involving the new fractional operator with IHFs in its kernel and classical Riemann Liouville(R-L) fractional integral and derivative operators, the Hilfer fractional derivative operator, the generalized composite fractonal derivate operaor are established. Results established by the authors in [1-3] follow as few interesting and significant special cases of our main results.
Extrapolated diagonal and off-diagonal splitting iteration method
Authors: Shokrpour Raheleh , Ebadi Ghodrat
Published: February 2023

Recently, Dehghan et al. presented the diagonal and off-diagonal splitting
(DOS) iteration method for solving the linear systems Ax = b [3]. In this
paper, we improve its convergence rate with extrapolation. Also convergence
analysis of extrapolated DOS (EDOS) iterative method is studied by giving an
upper bound of the extrapolation parameter, then consistency of EDOS and its
optimal extrapolation parameter are discussed. Finally, several numerical
examples are given to show the efficiency of the presented method.
On interpolative Hardy-Rogers type multivalued contractions via a simulation function
Authors: Karapınar Erdal , Ali Ahsan , Hussain Azhar , Hassen Aydi
Published: February 2023

In this paper, the notion of multivalued interpolative
Hardy-Rogers-contractions using generalized simulation functions is
introduced. We establish some related fixed point results and we provide
some examples. We also prove data dependence of the fixed point sets.
Moreover, we present strict fixed point set, well-posedness and homotopy
results.
Insulin Deficiency From Insulin Gene Mutation Leads to Smaller Pancreas
Authors: Wright Jordan J. , Williams Jonathan M. , Letourneau-Freiberg Lisa R. , Kandasamy Balamurugan , Reyes Demetra , Kanegusuku Anastasia Gant , Philipson Louis , Greeley Siri Atma W. , Hilmes Melissa A. , Powers Alvin C. , Virostko John , Moore Daniel J.
Published: February 2023

OBJECTIVE

To determine the mechanism of reduced pancreas size in type 1 diabetes and the significance of islet-derived insulin in pancreatic growth.

RESEARCH DESIGN AND METHODS

Using a validated and standardized MRI protocol, we measured pancreas volume and shape in a family with an autosomal-dominant insulin gene mutation that results in insulin deficiency similar in severity to that of type 1 diabetes but without autoimmunity. DNA sequencing confirmed the mutation in all four affected individuals and none of the four control family members. Insulin secretory capacity was determined by measuring postprandial urinary C-peptide.

RESULTS

Family members with this form of monogenic diabetes had a markedly smaller pancreas and a severely impaired postprandial C-peptide level than family members without diabetes.

CONCLUSIONS

These results suggest that severe insulin deficiency, rather than islet-directed autoimmunity, leads to reduced pancreas size in type 1 diabetes and that insulin is a major trophic factor for the exocrine pancreas.
Three-dimensional annular heat source for the thermal simulation of coaxial laser metal deposition with wire
Authors: Zapata Avelino , Zhao Xiao Fan , Li Shiyu , Bernauer Christian , Zaeh Michael F.
Published: February 2023

Coaxial laser metal deposition with wire (LMD-w) is an innovative additive manufacturing technology in which a wire is coaxially fed through the center of a hollow laser beam into a laser-induced melt pool. This special configuration results in a direction-independent process, which facilitates the manufacturing of thin-walled metal components at high deposition rates. However, laborious experimental test series must be conducted to adjust the process parameters so that the substrate and the part do not overheat. Therefore, models are needed to predict the resulting temperature field and melt pool dimensions efficiently. This paper proposes a finite element simulation model using an innovative heat source, which considers the unique intensity distribution of the annular laser spot. The heat source parameters were calibrated experimentally based on fusion lines obtained from metallographic cross sections of aluminum alloy samples (AA5087 wire and AA6082 substrate). Subsequently, the temperature distribution in the substrate plate was measured by means of thermocouples to validate the developed model. It was shown that the proposed heat source replicates the heat input accurately. With the presented model, essential features for process development, such as the temperature field and the melt pool dimensions, can be reliably predicted. The model contributes to a better understanding of the LMD-w process and facilitates an efficient process development in future research work as well as for industrial applications.

Key words: thermal simulation, annular laser spot, heat source, laser metal deposition, coaxial wire feeding, directed energy deposition
A Green Economy Approach to Solid Waste Management in Minna, Nigeria
Authors: Sanusi Yekeen Adeeyo , Owoyele Sundat Gideon , Medayese Samuel , Mohammed Ndana Tanko
Published: February 2023

This study is based on solid waste recycling activities in Minna, Nigeria. The objectives of the study are to take inventory of recycling outlets, to examine the recycling inputs and the products produced by the recyclers, to assess the operating environment of the recycling cluster and to investigate the livelihood opportunities that recycling generates. The result shows that the recycling cluster occupies an area of 0.64 hectares that accommodates 141 recycling outlets with about 40% of the outlets occupying below the standard shop size of 7.2m2. The recycling outlets use 18 types of recovered materials to reproduce   27 varieties of products. Each recycling outlet engages about 3.4 persons and offers training to an average of 6 persons each. In general, the sector contributes to creation of employment, income generation, skill development, asset building and social capital formation.
Spatial Variability of Total Nitrogen, pH, and Organic Carbon in Organic and Inorganic Farming
Authors: Wijayanto Yagus , Pamungkas Anggara Dwi
Published: February 2023

AbstractThere have been significant efforts to transform traditional farming into organic farming practices. It is believed that this transformation would guarantee the long term production while it also maintains the environment. Studying the differences between these two practices in the form of maps can be useful for understanding spatially how effective the transformation has been achieved. This is because soil varies in space. The main aim of this research is to study the spatial variability of Total Nitrogen, pH and Organic Carbon in the soil. Methods used in this study consists of : (a) data capture; (b) data input in GIS; (c) processing data using Kriging: (d) analysis and presentation of results. The results showed that : (a)Soil  organic content in the study area was generally low suggesting the future warning; (b) Using pH, Organic Carbon and Total N as indicators of assessing the differences between organic and inorganic practices, indicating that there has not been significant different between these practices; (c)The analysis of spatial variability using Kriging in GIS environment could uncover the spatial variability and suggested the way of managing the  study area. Keywords: organic farming, inorganic farming, spatial variability, soil properties
Jan Tinbergen and the Limits of Expertise
Authors: Dekker Erwin
Published: February 2023

As part of a book symposium on his Jan Tinbergen (1903–1994) and the Rise of Economic Expertise (2021), Erwin Dekker responds to commentaries by Mariana Mortágua and Francisco Louçã, Thomas Kayzel, Jon Murphy, Michele Alacevich, Mauro Boianovsky, and William Peden.
Koulutiedon eheyttäminen
Authors: Niemelä Mikko
Published: February 2023

Mikko A. Niemelän kasvatustieteen väitöskirja Knowledge-Based Curriculum Integration : Potentials and Challenges for Teaching and Curriculum Design tarkastettiin Helsingin yliopistossa 1.9.2022. Vastaväittäjänä toimi professori Jukka Husu (Turun yliopisto) ja kustoksena professori Kirsi Tirri (Helsingin yliopisto). Englanninkielinen väitöskirja on saatavilla sähköisesti: http://urn.fi/URN:ISBN:978-951-51-8252-4
Holocaust memoir literature after 1945 in Slovak and Italian cultural milieus
Authors: Galambošová Claudia
Published: February 2023

The paper is focused on the Holocaust memoir literature published after 1945 in Slovak and Italian cultural milieus and on the interliterary relations between these two literatures. The first part of the paper discusses the specifications of the memoir literature as a genre, presenting definitions by significant Slovak, Czech and Italian literary scholars. The second and the third parts explain the developement of the topic of the Holocaust within the Slovak and Italian cultural milieus and extends it in the Slovak-Italian interliterary context, pointing out some concrete examples of the contacts between the two literatures.
Desire and subjectivity in S. T. Coleridge’s “Frost at midnight”
Authors: Alizadeh Ghiasuddin , Farahmandfar Masoud , Ghiasuddin Alizadeh - Masoud Farahmandfar - Musa Abdollahi Ghiasuddin Alizadeh - Masoud Farahmandfar - Musa Abdollahi , Abdollahi Musa
Published: February 2023

The present article is an attempt to offer a fresh critical reading of Samuel Taylor Coleridge's poem "Frost at Midnight" based on the theoretical ideas of Jacques Lacan on desire and subjectivity. Coleridge's desire for a unified subjectivity lulls him into the dream of a bright future for his son, while the only ethical thing for him to do, from the psychoanalytical point of view, is to accept the split and, having traversed the fantasy and subjectified the cause of this split, to take responsibility for his unconscious mind. It is no wonder, then, that the poem begins and ends with the description of “frost’s secret ministry”; after all, the endless pursuit of desire qua the Other in search of a lost object which would complete the puzzle of one’s life is no pursuit at all; the act of moving in a circle of course means there is no actual movement or change in location.
Pre-Service Pre-School Teachers’ Music Education Self-Efficacy Levels: A Case Study
Authors: YÜCESAN Esra
Published: February 2023

Purpose: This study aims to examine pre-service preschool teachers’ music education self-efficacy levels in terms of their gender and grades.
Design: The research has been designed as descriptive research based on the survey model. The data collection tool includes the 'Music Education Self-Efficacy Scale for Preschool Teacher Candidates' developed by Yıldız (2017). The study group includes 221 pre-service preschool teachers.
Findings: Research indicates that pre-service preschool teachers' music education self-efficacy is at a 'good level.' Considering grades, it is found that as the grade level increases, there is an increase in the self-efficacy beliefs of pre-service preschool teachers related to music education. The lowest music education self-efficacy levels belong to freshman pre-service preschool teachers, and the highest music education self-efficacy levels belong to senior pre-service preschool teachers. However, it is found that the music education self-efficacy levels do not significantly differ according to gender.
Highlights: It draws attention to a significant increase in the music education self-efficacy belief levels of the 3rd and 4th grade pre-service preschool teachers who took 'Early Childhood Music Education' as a compulsory course in the 2nd year of undergraduate education.
Effect of Flow Rate on Adsorption Cadmium Ion (II) Using Activated Carbon of Langsat Shell (Lansium Domesticum Corr)
Authors: Nabila Farras Shafa , Kurniawati Desy
Published: February 2023

Cadmium is one of the dangerous heavy metals contained in industrial wastewater whose presence needs to be addressed. Adsorption is one method that can be used to reduce the levels of heavy metal ions contained in wastewater. Langsat peel activated carbon is used as an adsorbent to adsorb cadmium metal because it is easy to obtain and its use is still minimal in the community. The langsat peel was made into activated carbon with HNO3 activator as a metal ion absorber Cd2+ using the column method. The activated carbon obtained has been tested for quality according to the Indonesian National Standard (SNI) No.06-3730-1995. In this study, we determined the effect of flow rate on metal cadmium absorption. The results showed that the activated carbon met the quality standards set by SNI and the optimum value of Cd2+ metal ion adsorption was at a flow rate of 1 ml/min.
Adsorption of Lead Ion (II) Using Activated Carbon of Langsat Shell (Lansium domesticum Corr) with Column Method
Authors: Taufiq Muhammad , Kurniawati Desy
Published: February 2023

Lead (II) ion is one of the dangerous metal ions produced from various industrial wastes and its existence needs to be addressed. Adsorption using langsat peel activated carbon was proven to be able to absorb lead (II) ions. The stages of absorption are carried out by varying the adsorbent weight (0.2, 0.3, 0.4, and 0.5) g, and flow rate (1,2,3,4) mL/minute by column method then continued with testing using atomic absorption spectrophotometer (AAS). The results showed that the optimum conditions occurred at the weight of the adsorbent is 0.2 g, and the flow rate is 2 mL/min.
MENINGKATKAN WAWASAN TENTANG PENGETAHUAN TUJUH PRINSIP PALANG MERAH REMAJA PADA SISWA DI SD NEGERI PABEAN KABUPATEN PROBOLINGGO TAHUN 2022
Authors: Oktaviaji Firda , Karimah Inayatul , Santoso Marizah Yulia , Agustin Yulia , Suharwati Zulkha
Published: February 2023

Abstrak : Meningkatkan Wawasan Tentang Pengetahuan Tujuh Prinsip  Palang Merah Remaja Pada Siswa Di SD Negeri Pabean Kabupaten Probolinggo Tahun 2022. Palang Merah Remaja memiliki tujuh prinsip yaitu kemanusiaan, kesamaan, kenetralan, kemandirian, kesukarelaan, kesatuan, dan kesemestaan.  Ketujuh prinsip dalam palang merah remaja memiliki tujuan yang sama yaitu mengajarkan serta menerapkan budaya hidup tolong menolong, dan bersikap netral pada semua manusia. Adapun metode yang digunakan dalam kegiatan observasi di SD Negeri Pabean yaitu, metode kualitatif dan kuantitatif. Metode tersebut berupa penyampaian materi melalui teknik presentasi, kegiatan diskusi tanya jawab dan pemberian angket. Dari hasil diskusi yang kami lakukan dapat disimpulkan bahwa ketujuh prinsip tersebut sangat penting untuk diberikan kepada peserta didik, karena dapat diimplementasikan dalam kegiatan pengabdian masyarakat serta dalam kehidupan sehari-hari.
Efektivitas Dan Efisiensi Penyelenggaraan Angkutan Barang Di Kabupaten Langkat
Authors: TARIGAN HARIMIN
Published: February 2023

ABSTRAKTulisan ini bertujuan menganalisis aksesbilitas dan konektivitas jaringan jalan, penyelenggaraan angkutan barang dan upaya-upaya untuk menciptakan penyelenggaraan angkutan barang yang efektif dan efisien di Kabupaten Langkat. Hasil kajian menunjukkan aksesbilitas dan konektivitas jaringan jalan belum mendukung mobilitas angkutan barang dan penyelenggaraan angkutan barang belum terselenggara secara efektif dan efisien sehingga diperlukan upaya-upaya menciptakan penyelenggaraan angkutan barang yang efektif dan efisien melalui penetapan jaringan lintas angkutan barang dan terjalinnya kerjasama antar pemangku kepentingan (stakeholder) di bidang penyelenggaraan angkutan barang. Disarankan dalam penetapan jaringan lintas angkutan barang dilakukan peningkatan daya dukung jalan dan jembatan, perencanaan geometrik jalan, kecukupan  ruang bebas atas, pemenuhan fasilitas perlengkapan jalan, dan terkoneksi dengan pembangunan terminal barang.Kata Kunci : Efektif dan efisien, Penyelenggaraan angkutan barangABSTRACTThis paper aims to analyze the accessibility and connectivity of the road network, the implementation of freight transportation and efforts to create an effective and efficient implementation of freight transportation in Langkat Regency. The results of the study showed that the accessibility and connectivity of the road network has not supported the mobility of freight transportation and the implementation of freight transportation has not been carried out effectively and efficiently so that efforts are needed to create effective and efficient transportation through the establishment of a cross-freight network and the establishment of cooperation between stakeholders in the field of transportation of goods. It is recommended in the establishment of a cross-freight network to increase the carrying capacity of roads and bridges, geometric planning of roads, adequacy of upper free space, fulfillment of road equipment facilities, and connected to the construction of freight terminals.Keywords : Effective and efficient, Transportation of goods
PENGEMBANGAN ALAT PENGHANGAT KANDANG AYAM PEDAGING BERBASIS BIOGAS UNTUK PENUNJANG PRODUKTIVITAS KELOMPOK PETERNAK DESA SADAMANTRA, KECAMATAN JALAKSANA, KABUPATEN KUNINGAN
Authors: Komaro Mumu
Published: February 2023

Tujuan dari pengembangan ini adalah untuk mengatasi dampak negatif yang tinggi dari penggunaan pemanas kandang berbahan bakar batubara pada kesehatan peternak dan lingkungan serta untuk dapat meningkatkan produktivitas ternak ayam pedaging di Desa Sadamantra. Desa Sadamantra merupakan desa pemasok ayam pedaging terbesar di Kecamatan Jalaksana Kabupaten Kuningan, dengan perolehan hasil ayam pedaging mencapai 99.300 ekor/tahun. Namun dalam 5 tahun terakhir desa sadamantra mengalami penurunan jumlah produksi ayam pedaging hingga lebih 50%. Salah satu penyebabnya adalah karena suhu lingkungan yang rendah. Beberapa upaya telah dilakukan peternak, seperti membuat penghangat kandang media batubara, pelet kayu, dan gas LPG, namun sayangnya hal tersebut tidak ramah lingkungan. Metode yang digunakan dalam pengembangan ini yaitu kunjungan kelompok, diskusi kelompok, pratik pembuatan biogas dari kotoran sapi, dan promosi hasil kerja kelompok sasaran. Berdasarkan hasil pengujian dalam pengembangan ini, pemanas kandang ayam pedaging berbasis biogas pada kondisi penampungan maksimum dapat memanaskan kandang hingga waktu 90 menit dan bisa digunakan sebagai alternatif pemanas kandang ayam. Pemanas kandang ayam pedaging berbasis biogas yang dikembangkan berbahan dasar feses sapi yang diferementasi. Limbah hasil fermentasi biogas berupa pupuk organik dapat dimanfaatkan sebagai pupuk organik. Pupuk organik ini dapat digunakan sebagai pengganti pupuk kimia pada sektor pertanian di Desa Sadamantra.
A 2-es típusú diabetes mellitus antihiperglikémiás kezelésének változása Magyarországon 2015–2020 között – adatbáziselemzés országos adatai
Authors: Jermendy György , Kiss Zoltán , Rokszin György , Abonyi-Tóth Zsolt , Lengyel Csaba , Péter Kempler Péter , Wittmann István
Published: February 2023

Háttér és célkitűzés: Az elmúlt néhány évben a 2-es típusú diabetes mellitus (T2DM) farmakológiai kezelési lehetőségei jelentősen megújultak. Vizsgálatunk során a hazai T2DM-betegek antihiperglikémiás kezelésének 2015–2020 között bekövetkezett változásait kívántuk elemezni. Betegek és módszer: A retrospektív, országos jellegű vizsgálatot a Nemzeti Egészségügyi Alapkezelő adatbázisát elemezve végeztük. A T2DM antihiperglikémiás kezelésében bekövetkezett éves változásokat, a különböző terápiás rezsimek előfordulási arányát állapítottuk meg. Eredmények: Az incidens esetek száma 2015–2020 között 60 049-ről 29 865-re csökkent, míg a prevalens esetek száma 682 274-ről 752 367-re emelkedett. A metformin (MET) monoterápiás alkalmazása fordult elő a leggyakrabban (31% 2020-ban). Az inzulin (INS)-monoterápia prevalenciája fokozatosan, kis mértékben csökkent (29%-ról 27%-ra), a szulfonilurea (SU)-monoterápiáé jelentősen visszaszorult (37%-ról 20%-ra). A DPP-4-gátlók népszerűek maradtak 2020-ban: monoterápia: 5%, MET-tel kettős kombinációban: 12%, MET és SU-val hármas kombinációban: 5%. Az SGLT-2-gátlók használatának gyakorisága 1%-ról 4%-ra nőtt monoterápiában, <1%-ról 6%-ra MET-tel kettős kombinációban és <1%-ról 2%-ra hármas kombinációban (MET és SU vagy MET és DPP-4-gátló). A GLP-1-RA használatának gyakorisága fokozatosan nőtt, de alkalmazásuk 1–2% körül maradt monoterápiában és kombinációban. Kezdő (első) antihiperglikémiás szerként 2020-ban a MET volt a leggyakrabban használt készítmény (50%), ezt követte a SU (16%) és az INS (10%). MET-kezdőterápia után a korszerű készítmények megjelenése lassú és kis arányú volt: GLP-1-RA add-on megjelenése 2%, 3% és 4%, SGLT-2-gátlók gyakorisága 4%, 6% és 8% a megfigyelés 24. 48. és 72. hónapjánál. Következtetések: A 2015–2020 közötti vizsgálati periódusban a T2DM antihiperglikémiás farmakológiai kezelése terén fontos változásokat dokumentáltunk. Bár a változások követték az új szakmai ajánlásokat, azok mértéke és időbeni lefolyása várakozásaink alatt maradtak. Több erőfeszítést kell tennünk annak érdekében, hogy a kardiovaszkuláris/renális előnnyel rendelkező új készítmények a betegek minél nagyobb arányában és késedelem nélkül az antihiperglikémiás kezelés részévé váljanak.
The Influence of Brand Image and Product Innovation on Customer Repurchase Intention through The Mediation of Customer Satisfaction Towards Indomie
Authors: Ellitan Lena , Sindarto Juventino , Agung Deatri Arumsari
Published: February 2023

Purpose: To examine the effect of Indomie's brand image and productinnovation on repurchase intention either directly or throughcustomer satisfaction.

Method: This study uses quantitative methods to obtain significantresults and data collection in the form of an online questionnairethrough a google Forms. The total number of respondents obtained was 153respondents with a minimum age of 17 years or more, domiciled inSurabaya, and had consumed Indomie in the last three months. The datawere then analyzed using the structural equation model techniquewith the help of PLS 4 software.

Result: The results showed that brand image and product innovationhad a positive and significant impact on customer satisfaction andrepurchase intention, customer satisfaction had a positive andsignificant impact on repurchase intention and consumer satisfactionpartially mediated the relationship between brand image and productinnovation on repurchase intention.
Analysis of Factors Affecting Business Performance: Empirical Study of Hospitals in East Java
Authors: Afifi M. Fiyan , Murhadi Werner Ria
Published: February 2023

Purpose: Hospitalization in Indonesia continued to increase by 5.2% per year in 2018, with the most significant number of hospitals in Indonesia being in the province of East Java. However, Indonesia is the most important contributor to overseas medical visits. Total expenses reach IDR 161 trillion/year (US$ 11.5 billion/year), and 80% of visits are to Malaysia, where every year, million Indonesian citizens (WNI) seek treatment abroad. Of this amount, the total costs incurred reached IDR 97 trillion. This becomes a question, what triggers Indonesian citizens to seek treatment abroad? This study aims to analyze the factors that influence business performance in hospitals in East Java.

Methods: This study used a purposive sampling technique with a total sample of 62 respondents. Respondents in this study were hospital leaders in East Java. This study uses a quantitative approach with the analysis in this study using Smart PLS.

Result: the results show that environmental uncertainties hurt the business performance of the hospital. This result is due to environmental uncertainties being a broad factor, difficult to predict either individually or collectively. However, environmental uncertainties have a significant positive effect on strategic orientation. Environmental uncertainties have a negative and significant effect on managerial capability. Meanwhile, strategic direction and managerial capability have a positive and significant effect on the business performance of hospitals in East Java.
The Influence of Perceived Usefulness, Trust, and Risk on Loyalty in the TikTok Shop: Test of Consumer Satisfaction as a Mediation Variable
Authors: Harianto Elisabeth Fionna Evania , Ellyawati Jeanne
Published: February 2023

Purpose: This study aims to analyze the effect of perceived usefulness, trust and risk on loyalty with consumer satisfaction as a mediating variable at the TikTok Shop.

 

Method: This study's research method was a questionnaire survey. The population in this study were consumers born in 1997 – 2012 (generation Z) and had used the TikTok Shop ≥ 2 times. The sample in this study was 232 respondents. The sampling technique uses a non-probability sampling technique with a purposive sampling approach with an analytical tool, namely PLS-SEM (Partial Least Square - Structural Equation Modeling).

 

Results: The results of data analysis with a significance of 0.05 indicate that the effect of perceived usefulness on customer satisfaction and loyalty has no positive effect. The effect of trust on consumer satisfaction has a significant effect, but the effect of trust on consumer loyalty does not have a significant effect. The effect of risk on customer satisfaction and loyalty has a significant effect. The influence of consumer satisfaction mediates consumer loyalty.
Association between face covering policies and the incidence of coronavirus disease 2019 in European countries
Authors: Kim Sookhyun , Oh Jiyoung , Tak Sangwoo
Published: February 2023

Objectives: This study was conducted to determine the impact of the strengthening or relaxation of face covering mandates on the subsequent national case incidence of coronavirus disease 2019 (COVID-19) in Europe as the full vaccination rate was increasing.Methods: European countries in which case incidence increased for 3 consecutive weeks were monitored and analyzed using COVID-19 incidence data shared by the World Health Organization (WHO). The epidemic trend of COVID-19 in Europe was compared with that of countries elsewhere in the world based on WHO weekly epidemiological reports from June 20 to October 30, 2021. In addition, this study provided insight into the impact of government mask mandates on COVID-19 incidence in Europe by measuring the index scores of those facial covering policies before and after mandate relaxation or strengthening. The effects of the vaccination rate and the speed of vaccination on COVID-19 incidence were also analyzed.Results: The incidence of COVID-19 after the relaxation of face covering mandates was significantly higher than before relaxation. However, no significant difference was observed in vaccination rate between countries with increased and decreased incidence. Instead, rapid vaccination delayed the resurgence in incidence.Conclusion: The findings suggest that face covering policies in conjunction with rapid vaccination efforts are essential to help mitigate the spread of COVID-19.