bluuebunny/crossref_metadata_2025 huggingface dataset:
Deep-Learning-Based Antenna Alignment Prediction for Mobile Indoor Communication
Authors: Makara Árpád László , Csathó Botond Tamás , Rácz András , Borsos Tamás , Csurgai-Horváth László , Horváth Bálint Péter
Published: March 2023

A significant innovation for future indoor wireless networks is the use of the mmWave frequency band. However, an important challenge comes from the restricted propagation conditions in this band, which necessitates the use of beamforming and associated beam management procedures, including, for instance, beam tracking or beam prediction. A possible solution to the beam management problem is to use artificial-intelligence-based procedures to learn the hidden spatial propagation patterns of the channel and to use this knowledge to predict the best beam directions. In this paper, we present a deep-neural-network-based method that has memory that can be used to predict the best reception directions for moving users. The best direction is the highest expected signal level at the next moment. The resulting method allows for a user-side antenna management system. The result was evaluated using three different metrics, thus detailing not only its predictive ability, but also its usability.
Allotment Garden Products as Contribution to Sustainable and Resilient Cities: An Analysis in Leipzig, Germany
Authors: Schäfer Lotta , Kleemann Janina , Spyra Marcin
Published: March 2023

The food supply and the consumption of resources are already central challenges for the growing world population and increasing demands. Urban areas in particular face problems of resilience and sustainability. The development of alternative food systems by, e.g., urban gardening, can contribute to meet targets of sustainable consumption, inclusive economy, and resilient food systems of cities. Our research presents insights into the available harvest of products from allotments. In addition, the interest and motivation of gardeners to distribute products from their allotments was investigated. The analysis was based on a structured and standardized questionnaire with more than 90 allotment gardeners in Leipzig. Data were analyzed by means of descriptive statistics. Our results showed that especially zucchinis, tomatoes, berries, and apples could be distributed to consumers; however, the greatest obstacle involves the legal framework to economically distribute products from these allotments. On the other hand, some respondents showed that income generation from allotment products is less important than the enjoyment of the garden and the charitable goal of action. They suggested an organized distribution system of surplus from allotments to particularly disadvantaged people. This paper encourages re-examination of the conventional urban–rural relations, the production–consumption relationships, and the norms of economic activity.
Evolution of the Coupling Coordination between the Marine Economy and Digital Economy
Authors: Liu Yang , Jiang Yiying , Pei Zhaobin , Xia Na , Wang Aijun
Published: March 2023

Accelerating the high-quality integrated development of digital economy and marine economy is vital for the development of the marine economy in coastal countries and regions. However, few scholars examined such coordination. Here, based on panel data from 2012 to 2019 and the spatial scale of China’s coastal provinces and cities, the entropy method, coupling harmonious degree model (CCDM), Theil index, and Tobit model were adopted to measure and calculate the interval index differences in the marine economic quality and digital economy level. Exploring the coordination between the marine economy and digital economy, the interval difference index, and the coordination impact factors were also important. First, we found that the quality level of the marine economy and digital economy moved forward in waves and spiraled up, but that the quality of development was relatively low. Second, the coordination between the marine economy and digital economy gradually increased. Third, the coordination gap between the regional marine economy and digital economy was obvious. Fourth, the main factors that affected the coordination between the marine economy and digital economy were the level of digital infrastructure construction, the scale of the marine economy, the level of the marine industry, and industrial digitalization. The results have value for the sustainable development of the marine economy of coastal countries and regions.
Innovative Design Method of Jet Grouting Systems for Sustainable Ground Improvements
Authors: Shakya Sudip , Inazumi Shinya , Chao Kuo Chieh , Wong Ricky K. N.
Published: March 2023

The major focus of this study was determining the effectiveness of new construction specifications regarding the method of cement grout injection for the jet grouting system (high-pressure injection stirring method), with the objective of developing a sustainable ground improvement method. The recent innovative jet grouting techniques allow for improvement at middle pressure, but the mud discharge amount is drastically increased. This produces a serious environmental and financial burden during the disposal of mud discharge. This study attempts to develop a sustainable jet grouting method. The simulation model was prepared by the 3D AutoCAD software, and the analysis was conducted using the moving particle semi-implicit method (MPS method). The study focused on the changes that occurred in the mixing ratio of cement slurry and soil due to the changes made in cement milk spraying during the construction phase and compared it with the traditional method of cement milk spraying. All other construction parameters were kept the same for both cases, and the comparison result shows that the modified construction specification provides a denser and larger improved soil body than the traditional method. Furthermore, the density of the number of particles was determined at the upper, middle, and lower portions of the improved body for comparison.
Environmental Identities and Attitude towards Crude Oil Pipeline Vandalism in Niger Delta Oil-Producing Communities
Authors: Ozougwu Peterval E. , Madu Christian N. , Chukwuorji Johnbosco C. , Ozougwu Augustine O. , Ozougwu Stella U.
Published: March 2023

Environmental identities and attitude towards oil pipeline vandalism in Niger Delta oil-producing communities were examined to show whether low environmental identity is associated with an environmentally destructive attitude, as well as how such issues may be connected with incidents of oil pipeline vandalism in the area. A survey of youths (N = 603) from selected oil-producing communities in the Niger Delta area was conducted. A subset of the sample participated in focus group discussions, and ten experts were interviewed. Socioeconomic and demographic factors of participants were also investigated, as they might be associated with environmental identities and attitudes. The study found that the youths who scored medium to high on the environmental identity scale are more likely to be pro-environmental. There was also a significant association between gender and environmental identity scores. Occupation, education, and income levels were also associated with attitude towards oil pipeline vandalism. However, there was no significant association between environmental identity and attitude towards oil pipeline vandalism. The strong associations between socioeconomic factors, environmental identity, and attitude towards pipeline vandalism suggest that improved socioeconomic status may help to curb oil pipeline vandalism in the Niger Delta.
Chatbots in Education and Research: A Critical Examination of Ethical Implications and Solutions
Authors: Kooli Chokri
Published: March 2023

A new era of education and research based on chatbots and artificial intelligence is quickly growing. However, the application of these new systems is associated with several challenges and limitations, mainly related to ethics. This paper explores the potential use of AI systems and chatbots in the academic field and their impact on research and education from an ethical perspective. Through a qualitative methodology, the researcher perform exploratory research and data collection based on expert analysis and interpretation. The researcher conducted a comprehensive review of the main potential challenges associated with the use of chatbots in education and research to identify current practices, challenges, and opportunities. This explorative work provides a foundational understanding of the studied topic. It also helps us to better understand the subjective experiences and perspectives of the observed phenomenon, and uncovers their meanings and proposes potential solutions to the observed issues. This study examines the advantages and limitations of AI systems and chatbots, as well as their role in supporting human expertise and judgment. The paper also discusses the ethical challenges related to the use of AI systems and chatbots in research, as well as the potential for misuse and exploitation. It also proposes effective solutions to the observed ethical dilemmas. The research admits that we live in a new era of AI-based education and research. The observed technological advancements will definitely shift research processes and transform educative systems, especially in term of assessments. Digital assessments are going to disappear and assessment methods need to be more creative and innovative. The paper highlights the necessity of adaptation to the new reality of AI systems and chatbots. Co-living, sustainability and continuous adaptation to the development of these systems will become a matter of emergency. Raising awareness, adopting appropriate legislations and solidifying ethical values will strengthen research and protect educational systems. The presence of AI systems and chatbots in education needs to be considered as an opportunity for development rather than a threat.
GPS Data Analytics for the Assessment of Public City Bus Transportation Service Quality in Bangkok
Authors: Chawuthai Rathachai , Sumalee Agachai , Threepak Thanunchai
Published: March 2023

Evaluation of the quality of service (QoS) of public city buses is generally performed using surveys that assess attributes such as accessibility, availability, comfort, convenience, reliabilities, safety, security, etc. Each survey attribute is assessed from the subjective viewpoint of the service users. This is reliable and straightforward because the consumer is the one who accesses the bus service. However, in addition to summarizing personal feedback from humans, using data analytics has become another useful method for assessing the QoS of bus transportation. This work aims to use global positioning system (GPS) data to measure the reliability, accessibility, and availability of bus transportation services. There are three QoS scoring functions for tracking complete trips, on-path driving, and on-schedule operation. In the analytical process, GPS coordinates rounding is adopted and applied for detecting trips on each route path. After assessing the three QoS scores, it has been found that most bus routes have good operations with high scores, while some bus routes show room for improvement. Future work could use our data to create recommendations for policy makers in terms of how to improve a city’s smart mobility.
Mapping the Knowledge Structure and Unveiling the Research Trends in Social Entrepreneurship and Inclusive Development: A Bibliometric Analysis
Authors: Satar Mir Shahid , Aggarwal Deepanshi , Bansal Rohit , Alarifi Ghadah
Published: March 2023

Several kinds of research from both global and local perspectives have discussed social entrepreneurship and inclusive development. Accordingly, this article aims to highlight the key contributors (authors, institutions, countries, journals) and knowledge structure (co-authorship analysis and cooccurrence-of-keyword analysis) of this research domain. Utilizing the bibliographic data of 300 articles extracted from the Scopus database, we primarily employed Biblioshiny software, resulting in 673 authors from 69 different countries and 496 different institutions. Furthermore, the yearly publication of the 300 documents rose from 1 in 1996 to 24 in 2022, with an average age of 6.08 years and a citation rate of 13.79 yearly. Remarkably, the number of publications on this subject accelerated in 2014. According to the study’s findings, the most productive country in line with research publishing is the USA. The most productive institution has been recognized as the Amrita School of Engineering. The most active author is reported to be Kadol N. The most prolific journal is Entrepreneurship and Regional Development. In addition to this, the top three most frequent terms are ‘social development’, ‘economic development’ and ‘entrepreneur. ‘Social entrepreneurship’, ‘social and economic effects’, ‘sustainable development’ and ‘social development’ are the latest keywords in this field that predict future trends. Taken collectively, this review is an expedient resource for gaining a thorough grasp of the state of the art and prospective routes for future research.
Generative Adversarial Networks (GAN) and HDFS-Based Realtime Traffic Forecasting System Using CCTV Surveillance
Authors: Devadhas Sujakumari Praveen , Dassan Paulraj
Published: March 2023

The most crucial component of any smart city traffic management system is traffic flow prediction. It can assist a driver in selecting the most efficient route to their destination. The digitalization of closed-circuit television (CCTV) systems has resulted in more effective and capable surveillance imaging systems for security applications. The number of automobiles on the world’s highways has steadily increased in recent decades. However, road capacity has not developed at the same rate, resulting in significantly increasing congestion. The model learning mechanism cannot be guided or improved by prior domain knowledge of real-world problems. In reality, symmetrical features are common in many real-world research objects. To mitigate this severe situation, the researchers chose adaptive traffic management to make intelligent and efficient use of the current infrastructure. Data grow exponentially and become a complex item that must be managed. Unstructured data are a subset of big data that are difficult to process and have volatile properties. CCTV cameras are used in traffic management to monitor a specific point on the roadway. CCTV generates unstructured data in the form of images and videos. Because of the data’s intricacy, these data are challenging to process. This study proposes using big data analytics to transform real-time unstructured data from CCTV into information that can be shown on a web dashboard. As a Hadoop-based architectural stack that can serve as the ICT backbone for managing unstructured data efficiently, the Hadoop Distributed File System (HDFS) stores several sorts of data using the Hadoop file storage system, a high-performance integrated virtual environment (HIVE) tables, and non-relational storage. Traditional computer vision algorithms are incapable of processing such massive amounts of visual data collected in real-time. However, the inferiority of traffic data and the quality of unit information are always symmetrical phenomena. As a result, there is a need for big data analytics with machine learning, which entails processing and analyzing vast amounts of visual data, such as photographs or videos, to uncover semantic patterns that may be interpreted. As a result, smart cities require a more accurate traffic flow prediction system. In comparison to other recent methods applied to the dataset, the proposed method achieved the highest accuracy of 98.21%. In this study, we look at the construction of a secure CCTV strategy that predicts traffic from CCTV surveillance using real-time traffic prediction analysis with generative adversarial networks (GAN) and HDFS.
Parameter Estimation in the Mathematical Model of Bacterial Colony Patterns in Symmetry Domain
Authors: Brociek Rafał , Wajda Agata , Capizzi Giacomo , Słota Damian
Published: March 2023

The paper presents a solution to the problem related to the reconstruction of parameters in the mathematical model of bacterial colony patterns in a domain with symmetry. The inverse problem consists of determining the value of the diffusion coefficient of active bacteria. The model describing the distribution of active bacteria in a given region, as well as the concentration of the substrate over time is considered. Such a model consists of a system of partial differential equations with appropriate initial-boundary conditions. The finite element method was used to solve the direct problem. However, the Fibonacci search method was used to minimize the functional description of the error of the approximate solution.
Assessing the Occurrence and Distribution of Microplastics in Surface Freshwater and Wastewaters of Latvia and Lithuania
Authors: Pashaei Reza , Sabaliauskaitė Viktorija , Suzdalev Sergej , Balčiūnas Arūnas , Putna-Nimane Ieva , Rees Robert M. , Dzingelevičienė Reda
Published: March 2023

Microplastic concentrations in surface water and wastewater collected from Daugavpils and Liepaja cities in Latvia, as well as Klaipeda and Siauliai cities in Lithuania, were measured in July and December 2021. Using optical microscopy, polymer composition was characterized using micro-Raman spectroscopy. The average abundance of microplastics in surface water and wastewater samples was 16.63 ± 20.29 particles/L. The dominant shape group of microplastics in water was fiber, with dominant colors found to be blue (61%), black (36%), and red (3%) in Latvia. Similar distribution in Lithuania was found, i.e., fiber (95%) and fragments (5%) with dominant colors, such as blue (53%), black (30%), red (9%), yellow (5%), and transparent (3%). The micro-Raman spectroscopy spectra of visible microplastics were identified to be polyethylene terephthalate (33%) and polyvinyl chloride (33%), nylon (12%), polyester (PS) (11%), and high-density polyethylene (11%). In the study area, municipal and hospital wastewater from catchment areas were the main reasons for the contamination of microplastics in the surface water and wastewater of Latvia and Lithuania. It is possible to reduce pollution loads by implementing measures such as raising awareness, installing more high-tech wastewater treatment plants, and reducing plastic use.
Effects of Phytotoxic Nonenolides, Stagonolide A and Herbarumin I, on Physiological and Biochemical Processes in Leaves and Roots of Sensitive Plants
Authors: Tyutereva Elena V. , Dalinova Anna A. , Demchenko Kirill N. , Dmitrieva Valeriya A. , Dubovik Vsevolod R. , Lukinskiy Yuriy V. , Mitina Galina V. , Voitsekhovskaja Olga V. , Berestetskiy Alexander
Published: March 2023

Phytotoxic macrolides attract attention as prototypes of new herbicides. However, their mechanisms of action (MOA) on plants have not yet been elucidated. This study addresses the effects of two ten-membered lactones, stagonolide A (STA) and herbarumin I (HBI) produced by the fungus Stagonospora cirsii, on Cirsium arvense, Arabidopsis thaliana and Allium cepa. Bioassay of STA and HBI on punctured leaf discs of C. arvense and A. thaliana was conducted at a concentration of 2 mg/mL to evaluate phenotypic responses, the content of pigments, electrolyte leakage from leaf discs, the level of reactive oxygen species, Hill reaction rate, and the relative rise in chlorophyll a fluorescence. The toxin treatments resulted in necrotic and bleached leaf lesions in the dark and in the light, respectively. In the light, HBI treatment caused the drop of carotenoids content in leaves on both plants. The electrolyte leakage caused by HBI was light-dependent, in contrast with that caused by STA. Both compounds induced light-independent peroxide generation in leaf cells but did not affect photosynthesis 6 h after treatment. STA (10 µg/mL) caused strong disorders in root cells of A. thaliana leading to the complete dissipation of the mitochondrial membrane potential one hour post treatment, as well as DNA fragmentation and disappearance of acidic vesicles in the division zone after 8 h; the effects of HBI (50 µg/mL) were much milder. Furthermore, STA was found to inhibit mitosis but did not affect the cytoskeleton in cells of root tips of A. cepa and C. arvense, respectively. Finally, STA was supposed to inhibit the intracellular vesicular traffic from the endoplasmic reticulum to the Golgi apparatus, thus interfering with mitosis. HBI is likely to have another main MOA, probably inhibiting the biosynthesis of carotenoids.
Botulinum Neurotoxin Injections in Children with Self-Injurious Behaviors
Authors: Hull Mariam , Parnes Mered , Jankovic Joseph
Published: March 2023

Self-injurious behaviors are repetitive, persistent actions directed toward one’s body that threaten or cause physical harm. These behaviors are seen within a broad spectrum of neurodevelopmental and neuropsychiatric conditions, often associated with intellectual disability. Injuries can be severe and distressing to patients and caregivers. Furthermore, injuries can be life-threatening. Often, these behaviors are challenging to treat and require a tiered, multimodal approach which may include mechanical/physical restraints, behavioral therapy, pharmacotherapy, or in some cases, surgical management, such as tooth extraction or deep brain stimulation. Here, we describe a series of 17 children who presented to our institution with self-injurious behaviors in whom botulinum neurotoxin injections were found helpful in preventing or lessening self-injury.
Microbial and Biogeochemical Shifts in a Highly Anthropogenically Impacted Estuary (“El Sauce” Valparaíso)
Authors: Pozo-Solar Francisco , Cornejo-D’Ottone Marcela , Orellana Roberto , Acuña Carla , Rivera Cecilia , Aguilar-Muñoz Polette , Lavergne Céline , Molina Verónica
Published: March 2023

Coastal zones are ecosystems that are sensitive to climate change and anthropogenic pollution, resulting in a potential loss of biodiversity and ecosystem services through eutrophication and nutrient imbalances, among others. The coastal El Sauce catchment area, Central Chile, is under multiple anthropogenic pressures including wastewater treatment plant (WWTP) discharge, which its broad effect remains underexplored. In order to assess the impact of the WWTP on El Sauce stream, the benthic microbial communities and key functional groups variability (i.e., nitrifiers, methanogens and methanotrophs) were determined by 16S rDNA high-throughput sequencing and by functional genes quantification, respectively, during two contrasted seasons in three catchment areas (pre-, WWTP and post-discharge). The microbial communities’ structure profiles were associated with the water quality, nutrients, greenhouse gas (GHG) distribution, and the organic matter isotopic signatures in the sediments, for the first time, in this ecosystem. The results show that organic matter isotopic signatures using nitrogen and carbon (δ15N and δ13C) and the physicochemical conditions in El Sauce estuary changed from the pre- to WWTP discharge areas (i.e., a pH decrease of 0.5 units and an increase of 4–6 °C in the water temperature). The WWTP discharge area was characterized by a low nutrient concentration and significantly higher GHG distribution (>600 µM CO2, >30,000 nM CH4, and >3000 nM N2O). In addition, the benthic microbial community structure shifted spatially and seasonally, including specific phyla known as sewage bioindicators, such as Firmicutes (Clostridiales order) and Bacteroidetes. In addition, other taxa were enriched or only retrieved in the sediments of the WWTP influenced area, e.g., Tenericutes, Lentisphaerae, Synergistetes, and LCP-89. Methanogens were more enriched near the WWTP discharge compared to those in the pre-discharge site in both seasons, while methanotrophs and ammonia oxidizers were unfavored only during winter. Our results indicate that the WWTP discharge impacts the biogeochemical conditions in El Sauce catchment area modifying the benthic microbial communities, including a decrease in the key functional groups able to mitigate CH4 and regulate nutrients recycling in these aquatic ecosystems.
Style dominants of Martha Argerich’s musical creativity
Authors: Prodou Yevheniia
Published: March 2023

Statement of the problem.Musicology has accumulated quite a significant array of scientific works devoted to the study of individual performing style. But it is necessary to state that it remains insufficiently studied what features of the style of musical creativity of a particular personality are such that, on the one hand, are markers of its recognizability, and on the other – are responsible for its integrity. They can be defined as core or dominant.Creativity of M. Argerich embodies the basic trends in the development of modern piano art, and her influence on the development of modern pianism is difficult to overestimate, which determines the interest in identifying the style dominants of her musical creativity. Resent research and publications. The concept of style is one of the key concepts in modern musicology, where it is interpreted as a multilevel system. The prevalence of an individual style among others (Kaplienko-Iliuk, 2021), consideration of the style dominant as a factor that determines the formation of the performance idea (Sukhlenko, 2018) are presented, as well as the definition of the termin “style dominant” (Vardanyan, 2021) and the peculiarities of M. Argerich’s interpretation (Schwan, & Dragulin, 2021). Among methods used, the following can be outlined: historical, which reveals the properties of the development of piano art of the romantic tradition; comparative, necessary for comparing the performing versions of the composers’ works; stylistic, which outlines the specifics of the artistic expression of the individual; interpretive, which helps to identify the mechanisms of formation and implementation of the concept of the composer’s / performer’s musical work. The purpose of the research is to determine the style dominants of Martha Argerich’s creativity. Results and conclusions. Performing creativity is a multicomponent phenomenon, which consists of various factors that are subject not only to professional skills, but also adjusted by the personal structure, which consists of psychological and physiological characteristics, worldview and life guidelines. Since the style of the performer is one of the main features of an artistic individuality, it is obvious that the style dominant is an indispensable component of the comprehensive formation of this uniqueness. M. Argerich is an influential musician in today’s artistic culture, as the dominants of her style, including romantic orientation, tendency to chamber music and virtuosity, are appealing to both young audiences and professionalswith extensive musical and historical experience.
Effects of aspirin on kidney biopsy bleeding complications – a systematic review and meta-analysis (PROSPERO 2021 CRD42021261005)
Authors: Relvas Miguel , Gonçalves Joana , Castro Inês , Diniz Hugo , Mendonça Luís , Coentrão Luís
Published: March 2023

Post-procedural bleeding is the main complication of percutaneous kidney biopsy (PKB). Therefore, aspirin is routinely withheld in patients undergoing PKB to reduce the bleeding risk. The authors aimed to examine the association between aspirin use and bleeding during PKB. This systematic review and meta-analysis was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The article search was performed on the MEDLINE and SCOPUS using queries specific to each database. Article inclusion was limited to primary studies. The meta-analysis compared the risk of major bleeding events between the aspirin-exposed versus nonexposed group. Pooled effect estimate was examined using random-effects presented as odds ratio (OR) with 95% confidence intervals (CI). Heterogeneity was assessed through Cochrane I2 test statistics. Sensitivity and subgroup analyses were also performed according to kidney type. Ten studies were included in the review and four studies were included in the meta-analysis, reviewing a total of 34067 PKB. Definitions for significant aspirin exposure were inconsistent between studies, limiting comparisons. Studies with broader definitions for aspirin exposure mostly showed no correlation between aspirin use and post-biopsy bleeding. Studies with strict definitions for aspirin exposure found an increased risk for haemorrhagic events in the aspirin-exposed group. No significant differences were found between aspirin-exposed and the comparison group regarding major bleeding events [OR 1.72; 95% CI 0.50–5.89, I2 = 84%]. High-quality evidence on the effect of aspirin on the bleeding risk is limited. Our meta-analysis did not show a significantly increased risk for major bleeding complications in aspirin-exposed patients. Further studies are needed to define a more comprehensive approach for clinical practice.
Fixed Point Results of Rational Type-contraction Mapping in b-Metric Spaces with an Application
Authors: Hussein Mashkhas M. , Bin-Saad Maged G. , Al-Sayad Anter A.
Published: March 2023

In this article, we establish the existence of fixed points of rational type contractions in the setting of b-metric spaces and we verify the T-stability of the P property for some mappings. Also, we present a few examples to illustrate the validity of the results obtained in the paper. Finally, results are applied to find the solution for an integral equation.
Protección radiológica en terapias con 177Lu DOTATOC: tiempo de aislamiento, estimaciones de dosis a personas representativas y recomendaciones al paciente
Authors: Barbosa Parada Nathaly , Niño Duarte Franklin , Sandoval Castillo Lorena , Cely Segura Erika Xiomara
Published: March 2023

Introducción: El 177Lu-DOTA-péptido ha mostrado eficacia en el tratamiento de tumores neuroendocrinos, conllevando un aumento de terapias en el Instituto Nacional de Cancerología ESE. La normatividad nacional e internacional no cuenta actualmente con protocolos asociados al alta de pacientes tratados con 177Lu.
Objetivo: El propósito de este estudio es establecer recomendaciones de alta de pacientes tratados con 177Lu-DOTATOC que garanticen las condiciones de seguridad y protección radiológica a los cuidadores y familiares a partir de la evaluación de las dosis efectivas a este grupo representativo.
Materiales y métodos: Análisis retrospectivo de terapias con 177Lu-DOTATOC administradas a 9 pacientes con tumores neuroendocrinos. Se realizó dosimetría interna y se estimó la tasa de dosis para tiempos posteriores a la administración. Se modelaron situaciones a personas representativas (pacientes y público) para estimación de dosis efectiva para los cuatro ciclos de tratamiento.
Resultados: Se encontraron tiempos de semivida efectivo, rápido y lento de 4,96 ± 0,94 y 61,02 ± 4,14 horas, con tasa de dosis estimada a un metro del paciente a las 6 horas de 25,5 μSv/h y de 9,0 μSv/h a las 24 horas. En personas representativas se encuentra una mayor dosis efectiva a dormir con la pareja durante ocho horas a 0.3 metros. Los resultados están 10% por debajo del límite de público anual y cerca de 80% por debajo del límite a cuidadores.
Conclusión: Salvo condiciones clínicas, las terapias con 177Lu DOTATOC se pueden dar de alta de forma segura luego de 6 horas de aislamiento posteriormente a su administración, o con una tasa de dosis inferior a 25,5 μSv/h, sin afectar las condiciones de seguridad radiológica para acompañantes o cuidadores, personal ocupacionalmente expuesto y público en general, mientras se mantengan las recomendaciones de protección radiológica sugeridas en el presente estudio.
Etiología de falsos positivos del 18F-FDG PET-CT de ganglios mediastinales e hiliares con biopsia quirúrgica en pacientes oncológicos
Authors: Carvajal Fierro Carlos Andrés , Naranjo Mónica , Carreño Dueñas Jos´é Alexander , Chinchilla Trigos Luis Alberto , Alvarado Sarzosa Fernando , Buitrago Ramirez Miguel Ricardo , Callejas Gutiérrez Ana Milena , Beltrán Rafael José
Published: March 2023

Objetivo: El objetivo fue describir la etiología de los falsos positivos del 18 F-FDG PET/CT y sus asociaciones con características clínicas e imagenológicas en los pacientes oncológicos sometidos a biopsia quirúrgica de ganglios mediastinales e hiliares, en el Instituto Nacional de Cancerología, en un periodo de 8 años.
Métodos: Estudio retrospectivo y analítico.
Resultados: Se incluyeron 93 pacientes con una mediana de edad de 64 años (RIC:55-70) y 57% eran mujeres. 35,5% de los pacientes tenía cáncer de pulmón, seguido de linfoma en 21,5%. 43% de los pacientes eran fumadores y 17,2% tenían exposición por combustión de biomasa. De los 93 pacientes, se biopsiaron 220 estaciones ganglionares mediastinales e hiliares. 37 (16,8%) estaciones ganglionares correspondieron a falsos positivos del 18F-FDG PET-CT. La etiología fue antracosis en 19 (51,4%) estaciones, sarcoidosis en 8 (21,6%) estaciones, negativo para malignidad en 7 (18,9%) estaciones, y solo dos estaciones fueron granulomas. Se encontró una asociación estadísticamente significativa entre los falsos positivos con las estaciones ganglionares de los pacientes ≥ 65 años (P=0,008) y pacientes con antecedente de tabaquismo (P=0,021). Además, una asociación entre los verdaderos positivos y las adenomegalias (P=0,033).
Conclusiones: La principal etiología de los falsos positivos del 18F-FDG PET-CT fue antracosis. En cambio, los granulomas no fueron una etiología importante. Se encontró una asociación entre los falsos positivos con las estaciones ganglionares de los pacientes ≥ 65 años y pacientes con antecedente de tabaquismo. Además, se encontró la misma asociación entre los verdaderos positivos y los ganglios de las estaciones considerados adenomegalias en el 18F-FDG PET-CT.
Frecuencia de las mutaciones en los genes JAK2, MPL y CALR en las neoplasias mieloproliferativas crónicas BCR::ABL1 negativas, en dos instituciones hospitalarias de la ciudad de Medellín, durante el periodo 2020-2021
Authors: Pino Palacios Erika Yuleza , Acevedo Toro Paola Andrea , Gálvez Cárdenas Kenny Mauricio , Aristizábal Bernal Beatriz Helena
Published: March 2023

Antecedentes: En la clasificación de la OMS del año 2016, el subgrupo de neoplasias mieloproliferativas crónicas (NMPC) BCR::ABL1 negativas está constituido por 3 entidades: policitemia vera (PV), trombocitemia esencial (TE) y mielofibrosis primaria (MFP), las cuales se caracterizan por presentar mutaciones en los genes JAK2, MPL y CALR con un valor diagnóstico y pronóstico importante.
Objetivo: Determinar la frecuencia de las mutaciones en los genes JAK2, MPL y CALR en las neoplasias mieloproliferativas crónicas BCR::ABL1 negativas y explorar la asociación entre los tipo de neoplasias mieloproliferativas crónicas negativas, el estado mutacional y los parámetros del hemograma en pacientes provenientes de dos instituciones hospitalarias de la ciudad de Medellín durante el periodo 2020-2021.
Métodos: Estudio observacional descriptivo transversal, donde se incluyeron pacientes con diagnóstico de NMPC BCR::ABL1 negativa. Se evaluaron los genes JAK2, MPL y CALR mediante secuenciación masiva utilizando el panel TruSight One de illumina®. Se realizó un análisis descriptivo a través de la estimación de frecuencias relativas y absolutas o medidas de resumen (tendencia central, dispersión o posición) según la naturaleza de las variables.
Resultados: Un total de 24 pacientes fueron incluidos en el estudio, el 37,5% de los casos correspondieron a pacientes con TE. La distribución de acuerdo con el estado mutacional fue: No mutados o triple negativos 13 casos (54,2%) y mutados 11 casos (45,8%). Las mutaciones patogénicas encontradas en orden de frecuencia fueron JAK2 82%, MPL 9% y CALR 9%.
Conclusión: Nuestro estudio es consistente con lo reportado en la literatura mundial, siendo JAK2 V617F la mutación más frecuentemente encontrada en NMPC BCR::ABL1 negativa. Las frecuencias menores para CALR y MPL pueden estar influenciadas por el tamaño de la muestra.
البُعد الاصلاحي الاجتماعي في آيات الأحكام المتعلقة بالطلاق في سورة البقرة
Authors: Jalal Yahya , Mashaqbeh Hala , Zaqzouq Nidaa , Abu Suailiq Sana
Published: March 2023

الأهداف: يسلط هذا البحث الضوء على التوجيهات الإصلاحية الاجتماعية التي احتوت عليها الآيات القرآنية المتعلقة بموضوع الطلاق في سورة البقرة. كما سيبيّن البحث أثر هذه التوجيهات في إصلاح المجتمعات، وتجاوز الأزمات التي ترافق عادةً ظروف الطلاق.
المنهجية: المنهج المتّبَع في هذا البحث هو المنهج الاستقرائي، وذلك باستقراء الآيات الكريمة المتعلقة بموضوع الدراسة. وكذلك المنهج التحليلي الاستنباطي، وذلك بتحليل مفردات الآيات وتراكيبها، واستنباط ما فيها من أبعاد إصلاحية، وإرشادات اجتماعية.
النتائج: استخلصت الدراسة الحالية أبرز التوجيهات القرآنية التي احتوتها آيات أحكام الطلاق في سورة البقرة، وبيّنت أنها اشتملت على ضرورة بذل الجهد في إصلاح ما وقع بين الزوجين، وضرورة التزام كل طرف منهما بواجباته، وبحقوق الطرف الآخر، واشتملت كذلك على الدعوة إلى العفو والتسامح، وعدم نسيان الجميل، وأخذ القرار الحكيم، والتزام الأخلاق العالية في كافة الأحوال، وتعظيم أوامر الله، وعدم إساءة استعمالها أو استغلالها لأبعاد شخصية، وضرورة ترجمة الإيمان إلى سلوك يبِين عن صِدق صاحبه. وبيّنت الدراسة أهمية هذه التوجيهات ودورها في المحافظة على صلاح المجتمع وأمنه وتماسكه، فهي توجيهات حكيمة تناسب ظرف الطلاق الذي تكون فيه الأجواء مشحونة -غالبا- بالغضب والبغضاء، ويكون الناس بحاجة إلى التعامل معه دون انعكاسات سلبية على المجتمع.
الخلاصة: خلصت الدراسة إلى توجيه عناية الباحثين للكشف عن البعد الإصلاحي في آيات أخرى في القرآن الكريم، وخاصة آيات الأحكام والتشريع. وكذلك الاستفادة عمليا من الوصايا القرآنية في إصلاح الأسرة، وإصلاح المجتمعات عموما.
Jurisprudential Maxims and Canons Related to Diseases and Epidemics and their Jurisprudential Implementation: Covid-19– as a Model
Authors: Nasr Desouky Youssef Desouky
Published: March 2023

Objectives: To expound the accuracy of the Islamic legislation, and highlight its utmost consideration to every large and small detail related to Man when being healthy and at times of diseases and epidemics and to link between the jurisprudential maxims and canons related to diseases and epidemics with the jurisprudential derivatives based on them.
Methods: The inductive-analytical method was adopted through tracing and extrapolating texts from the Qur'an, Sunnah and scholars' views then analyzing them to reach a general ruling that links the maxim with its jurisprudential derivatives.
Results: The importance of jurisprudential maxims and canons in the Islamic legislation in regulating the derivatives and contemporary jurisprudential matters that are based on them and that a jurisprudential maxim is a holistic jurisprudential matter by which religio-rulings of different topics based on it are reached. Furthermore, the study showed that "hardship begets ease", "anything narrowed shall be broadened; and anything broadened shall be narrowed". Results also showed that "necessities render prohibited things permissible", and "there should be neither harming nor reciprocating harm". Additionally, results showed that "the jurisprudential canon is a holistic matter dedicated to one topic under which similar matters are ordered". And among the many jurisprudential canons related to diseases and epidemics that are stated in this search are: "collective prayer is waived by hardship", "fasting is indivisible" and " pilgrimage is based on easiness".
Conclusions: Impotance of gathering maxims related to diseases and epidemics in a comprehensive encyclopedia.
ظاهرة الشكوى في شعر ابن الحدّاد الأندلسي: قراءة نفسية لحيل الدفاع اللاشعورية
Authors:   Irbed University, Al- suodi Nezar
Published: March 2023

This study aims to expose complaint phenomenon in Ibn Al-Haddad Al-Andalusy poetries, with dependency on psychological method. The study found that the poet used to depend on defense mechanism for the unconsciousness which was presented by Freud’s study of interpreting dreams. The most important of these defense mechanisms are symbolization, displacement, fantasy, reaction formation, condensation and sublimation. The study concluded that the complaints of Ibn Al-Haddad were presented in two frames; the complaint of political power and the complaint of his own social status. He relied on defense mechanism to ease his unconsciousness pain; as he felt neglected by Almutasim Bin Sumadeh and Almoqtader Bin Houd. Ibn Al-Haddad also complained about the abandonment of his beloved “Nowayra”, as well as his complaint of people’s betrayal, and many envious and competitors who attached his poems. Despite of his direct complaint sometimes, Ibn Al-Haddad relied on using a language that presented him as a smart and deceptive person.
Spolupráce s vědami o neživé přírodě v počátcích české archeologie
Authors: Sklenář Karel
Published: March 2023

Článek sleduje počátky vztahů české archeologie k přírodním vědám od 30. let 19. století. Zatímco spolupráce s mineralogií a petrografií se jednostranně omezovala na expertizu (určení surovin kamenných, vesměs broušených artefaktů pro účely evidenčního popisu) a iniciativa v počátcích výzkumu kvartéru a paleolitu od 40. let 19. století vycházela naopak od přírodovědců (geologů a paleontologů) téměř bez aktivní účasti archeologů, vztah archeologie a chemie se naopak vyvíjel k oboustranné spolupráci. Začínal ve 30. letech zkoumáním „spečených valů“, vyšší úrovně dosáhl od roku 1847 na poli chemické analýzy složení bronzových artefaktů, jejímž iniciátorem (jako první v celé tehdejší rakouské říši) a zčásti i aktivním účastníkem byl archeolog prof. Jan Erazim Vocel. Tato činnost trvala do konce 60. let a jejím výsledkem bylo roztřídění a chronologické seřazení bronzů podle poměru kovů v jejich obsahu; v tomto směru se Vocel už v letech 1853–1855 dopracoval k sekvenci vcelku odpovídající dnešnímu stavu poznání. Na prahu pozitivistické epochy tak prakticky naplňoval svoji zásadu přiblížení archeologie k exaktním přírodním vědám.
Komorbid Kardiovaskular dan Gastrointestinal pada Coronavirus Disease 2019 (COVID-19)
Authors: Somalinggi Emmanuella E. N. A , Wantania Frans E. N. , Waleleng Bradley J.
Published: March 2023

Abstract: COVID-19 patients have various clinical characteristics. Patients who come with co-morbidities are more at risk of experiencing more severe symptoms and higher risk of death.  This study aimed to obtain cardiovascular and gastrointestinal comorbidities of coronavirus disease-2019 (COVID-19). This was a literature review study. The literature search was performed by using ScienceDirect, PubMed and Clinical key databases with “Comorbid AND Cardiovascular AND COVID-19” and “Comorbid AND Gastrointestinal AND COVID-19” for the keywords. After searching and filtering the literatures based on inclusion and exclusion criteria, finally 10 literatures were determined to be reviewed. The ten literature reviews showed that COVID-19 patients had cardiovascular comorbidities including hypertension, coronary heart disease (CHD), heart failure, and atrial fibrillation. Gastrointestinal comorbidities found include chronic gastritis, peptic ulcer, gastroesophageal reflux disease (GERD), inflammatory bowel disease (IBD), irritable bowel disease, diverticular disease, gastrointestinal tumors and polyps. In conclusion, patients with COVID-19 have varieties of comorbidities, and the most common one is hypertension and GERD.
Keywords: cardiovascular comorbidity; gastrointestinal comorbidity; COVID-19
 
Abstrak: Pasien COVID-19 memiliki karakteristik klinis yang beragam. Pasien dengan penyakit penyerta lebih berisiko mengalami gejala yang lebih berat dan risiko kematian lebih tinggi. Penelitian ini bertujuan untuk mengetahui komorbid kardiovaskular dan gastrointestinal dari coronavirus disease-2019 (COVID-19). Penelitian dilakukan menggunakan metode literature review. Pencarian literatur dilakukan pada tiga database yaitu PubMed, ScienceDirect dan ClinicalKey dengan kata kunci “Comorbid AND Cardiovascular AND COVID-19” serta “Comorbid AND Gastrointestinal AND COVID-19”. Setelah melalui proses pencarian dan penyaringan literatur berdasarkan kriteria inklusi dan ekslusi, akhirnya ditetapkan 10 literatur untuk ditelaah. Hasilnya sebanyak sepuluh tinjauan literatur menunjukkan pasien COVID-19 memiliki komorbid kardiovaskular antara lain hipertensi, penyakit jantung koroner (PJK), gagal jantung, dan fibrilasi atrial. Komorbid gastrointestinal yang ditemukan antara lain gastritis kronik, ulkus peptikum, gastroesophageal reflux disease (GERD), inflammatory bowel disease (IBD), irritable bowel disease, diverticular disease, tumor dan polip saluran cerna. Simpulan penelitian ini ialah pasien dengan COVID-19 memiliki berbagai jenis komorbid, dan yang terutama ialah hipertensi dan GERD.
Kata kunci: komorbid kardiovaskular; komorbid gastrointestinal; COVID-19
Extreme Wrong Committed by National and Supranational Inactivity. Extremes Unrecht durch national- und überstaatliches Unterlassen
Authors: Buchholz-Schuster Eckardt
Published: March 2023

The maritime distress of migrants on the high seas and the anthropogenic climate change represent two of the most significant humanitarian and political challenges of our time. Referring to the Radbruch formula, this paper examines the question of whether state and supranational failure to act on these two complex problems can be classified as extreme injustice from a legal ethical perspective, and what minimum ethical requirements this would imply for states and communities of states. A plea is made for the development and use of corresponding analyses and discourses as normative guidance - doing applied legal philosophy, not only for migrant and climate protection politics, but also for law makers and public discourse. Die Seenot von Migranten auf hoher See und der anthropogene Klimawandel stellen zwei der größten humanitären und politischen Herausforderungen unserer Zeit dar. Unter Bezugnahme auf die Radbruch'sche Formel geht Eckardt Buchholz-Schuster der Frage nach, ob national- und überstaatliches Unterlassen in Bezug auf diese beiden komplexen Probleme aus rechtsethischer Perspektive als extremes Unrecht eingestuft werden kann und welche ethischen Mindestanforderungen dieser Befund für Staaten und Staatengemeinschaften impliziert. Er plädiert dafür, entsprechende Analysen und Diskurse als normative Orientierungshilfe zu entwickeln und zu nutzen - angewandte Rechtsphilosophie für Migrations- und Klimaschutzpolitik, aber auch für Gesetzgeber und öffentlichen Diskurs.