bluuebunny/crossref_metadata_2025 huggingface dataset:
Oxidative Stress Biomarkers in Male Infertility: Established Methodologies and Future Perspectives
Authors: Mottola Filomena , Palmieri Ilaria , Carannante Maria , Barretta Angela , Roychoudhury Shubhadeep , Rocco Lucia
Published: April 2024

Male fertility can be affected by oxidative stress (OS), which occurs when an imbalance between the production of reactive oxygen species (ROS) and the body’s ability to neutralize them arises. OS can damage cells and influence sperm production. High levels of lipid peroxidation have been linked to reduced sperm motility and decreased fertilization ability. This literature review discusses the most commonly used biomarkers to measure sperm damage caused by ROS, such as the high level of OS in seminal plasma as an indicator of imbalance in antioxidant activity. The investigated biomarkers include 8-hydroxy-2-deoxyguanosine acid (8-OHdG), a marker of DNA damage caused by ROS, and F2 isoprostanoids (8-isoprostanes) produced by lipid peroxidation. Furthermore, this review focuses on recent methodologies including the NGS polymorphisms and differentially expressed gene (DEG) analysis, as well as the epigenetic mechanisms linked to ROS during spermatogenesis along with new methodologies developed to evaluate OS biomarkers. Finally, this review addresses a valuable insight into the mechanisms of male infertility provided by these advances and how they have led to new treatment possibilities. Overall, the use of biomarkers to evaluate OS in male infertility has supplied innovative diagnostic and therapeutic approaches, enhancing our understanding of male infertility mechanisms.
Perspective of Hydrodynamics in Microbial-Induced Carbonate Precipitation: A Bibliometric Analysis and Review of Research Evolution
Authors: Omoregie Armstrong Ighodalo , Ouahbi Tariq , Ong Dominic Ek Leong , Basri Hazlami Fikri , Wong Lin Sze , Bamgbade Jibril Adewale
Published: April 2024

Microbial-induced carbonate precipitation (MICP) is a promising process with applications in various industries, including soil improvement, bioremediation, and concrete repair. However, comprehensive bibliometric analyses focusing on MICP research in hydrodynamics are lacking. This study analyses 1098 articles from the Scopus database (1999–2024) using VOSviewer and R Studio, identifying information on publications, citations, authors, countries, journals, keyword hotspots, and research terms. Global participation from 66 countries is noted, with China and the United States leading in terms of contributions. The top-cited papers discuss the utilisation of ureolytic microorganisms to enhance soil properties, MICP mechanisms, concrete deterioration mitigation, soil and groundwater flow enhancement, biomineral distribution, and MICP treatment effects on soil hydraulic properties under varying conditions. Keywords like calcium carbonate, permeability, and Sporosarcina pasteurii are pivotal in MICP research. The co-occurrence analysis reveals thematic clusters like microbial cementation and geological properties, advancing our understanding of MICP’s interdisciplinary nature and its role in addressing environmental challenges.
Facilitators and Barriers to Lung Cancer Screening during Long COVID: A Global Systematic Review and Meta-Study Synthesis of Qualitative Research
Authors: Gebremeskel Teferi Gebru , Romeo Frank , Shama Adisu Tafari , Bonevski Billie , Trigg Joshua
Published: April 2024

Background: Participation in targeted screening reduces lung cancer mortality by 30–60%, but screening is not universally available. Therefore, the study aimed to synthesize the evidence and identify facilitators and barriers to lung cancer screening participation globally. Methods: Two reviewers screened primary studies using qualitative methods published up to February 2023. We used two-phase synthesis consistent with a meta-study methodology to create an interpretation of lung cancer screening decisions grounded in primary studies, carried out a thematic analysis of group themes as specific facilitators and barriers, systematically compared investigations for similarities and differences, and performed meta-synthesis to generate an expanded theory of lung cancer screening participation. We used the Social Ecological Model to organize and interpret the themes: individual, interpersonal, social/cultural, and organizational/structural levels. Results: Fifty-two articles met the final inclusion criteria. Themes identified as facilitating lung cancer screening included prioritizing patient education, quality of communication, and quality of provider-initiated encounter/coordination of care (individual patient and provider level), quality of the patient–provider relationship (interpersonal group), perception of a life’s value and purpose (cultural status), quality of tools designed, and care coordination (and organizational level). Themes coded as barriers included low awareness, fear of cancer diagnosis, low perceived benefit, high perceived risk of low-dose computerized tomography, concern about cancer itself, practical obstacle, futility, stigma, lack of family support, COVID-19 fear, disruptions in cancer care due to COVID-19, inadequate knowledge of care providers, shared decision, and inadequate time (individual level), patient misunderstanding, poor rapport, provider recommendation, lack of established relationship, and confusing decision aid tools (interpersonal group), distrust in the service, fatalistic beliefs, and perception of aging (cultural level), and lack of institutional policy, lack of care coordinators, inadequate infrastructure, absence of insurance coverage, and costs (and organizational status). Conclusions: This study identified critical barriers, facilitators, and implications to lung cancer screening participation. Therefore, we employed strategies for a new digital medicine (artificial intelligence) screening method to balance the cost–benefit, “workdays” lost in case of disease, and family hardship, which is essential to improve lung cancer screening uptake.
Home Care for the Elderly: An Integrated Approach to Perception, Quality of Life, and Cognition
Authors: Genaro Luis Eduardo , Marconato José Victor , Tagliaferro Elaine Pereira da Silva , Pinotti Felipe Eduardo , Valsecki Júnior Aylton , Adas Saliba Tânia , Rosell Fernanda Lopez
Published: April 2024

This study investigated the impact of home care, health status, and cognition. A qualitative and quantitative approach was employed through a cross-sectional study with a sample of 60 elderly individuals in need of home care in the municipality of Itatiba, São Paulo, Brazil. The analysis utilized the Discourse of the Collective Subject (DCS), EQ-5D, EQ VAS, and Mini-Mental State Examination (MMSE). The sample consisted of 40.0% male and 60.0% female individuals. The majority (61.6%) received weekly visits, mainly from community health agents, who were responsible for the majority of the care (45%). Positive considerations were highlighted, with 36.6% emphasizing the contribution to treatment continuity. The EQ VAS assessment indicated a moderately good perception of health. The EQ-5D analysis revealed significant differences between genders in personal care (p = 0.04). There were significant differences between clinical characteristics and EQ-5D dimensions, such as neoplasia and reduced mobility (p = 0.04), and arthritis/osteoarthritis/rheumatism and a limitation in common activities (p = 0.01). The presence of anxiety/depression was significant in cases of neoplasia (p = 0.006), arthritis/osteoarthritis/rheumatism (p = 0.01), and stroke (p = 0.04). The logistic regression analysis showed associations between usual activities and arthritis, osteoarthritis, rheumatism (p = 0.034), pain/malaise and arthritis, osteoarthritis, rheumatism (p = 0.038), and anxiety/depression and stroke (p= 0.028). The average MMSE scores (17.52) suggested a mild cognitive impairment, with no statistical differences between genders. Based on these results, it can be concluded that home care can provide a comprehensive approach and continuous assistance, emphasizing the importance of personalized care based on perceived and clinical differences.
Primary Health Care and Tuberculosis Detection during the COVID-19 Pandemic: Crucial Actions for Intensifying Efforts
Authors: Ribeiro Stephanie , Takahashi Erika Mayumi , Souza Katia Lacerda de , Yamamoto Thais Tiemi , Leite Raquel Russo , Fernandes Hugo , Okuno Meiry Fernanda Pinto , Bertolozzi Maria Rita , Figueiredo Tânia Maria Ribeiro Monteiro de , Gonzales Roxana Isabel Cardozo , Hino Paula
Published: April 2024

Background: Tuberculosis has been considered a global emergency since 1993, and controlling it has become even more challenging since 2020 due to the health and social crisis resulting from the COVID-19 pandemic. This study aimed to identify the impact of the COVID-19 pandemic on tuberculosis case detection activities within primary health Care in the largest city in Brazil. Methods: This is a cross-sectional and analytical study on the provision of tuberculosis detection actions in primary healthcare units during the pandemic period. A descriptive analysis was performed for characterization, and Generalized Mixed Models were used for evaluating associations, with a Bonferroni post hoc test applied. Results: The study sample comprised 80 health units in the municipality. There was a moderate alteration level in the provision of consultations for individuals with signs and symptoms of tuberculosis in 2020 (13.8%) and in 2021 (15.1%). Statistical significance (p < 0.05) was found between the pandemic period and detection actions, with a lower alteration level in 2022. Conclusions: Tuberculosis detection activities underwent changes due to the COVID-19 pandemic, mainly in 2020, which was associated with alterations in consultation and case notification provision.
Pediatric Oral Health Online Education for Rural and Migrant Head Start Programs in the United States
Authors: Ramos-Gomez Francisco , Parkinson Stephanie , Garcia de Jesus Victor , Rios Jose A. , Kinsler Janni J.
Published: April 2024

Children living in rural and migrant areas in the United States disproportionately suffer from poor oral health. Additionally, there continues to be a shortage of pediatric dentists practicing in rural/migrant areas. The purpose of this formative research study was to assess whether staff, teachers and families from rural/migrant Head Start/Early Head Start (HS/EHS) programs in California were receptive to oral health online education workshops conducted by pediatric dental residents who were assisted by bilingual (English and Spanish) community oral health workers (COHWs). Our findings suggest that partnering pediatric dental residents with bilingual COHWs to educate HS/EHS teachers, staff and parents on oral health care in rural/migrant areas could result in a rewarding experience for pediatric dentists that might lead them to practice in these communities upon graduation from their residency program. Furthermore, the positive feedback received from the teachers, staff and parents who participated in the workshops indicates they were receptive to receiving oral health information related to oral health literacy from the dental providers and COHWs. COHWs can help increase access to oral health care by serving as a bridge between families and providers by relaying information in a cultural, linguistic and sensitive manner.
Wrist Circumference Cutoff Points for Determining Excess Weight Levels and Predicting Cardiometabolic Risk in Adults
Authors: Pereira Larissa Monteiro Costa , Souza Márcia Ferreira Cândido de , Aidar Felipe J. , Getirana-Mota Márcio , Santos-Junior Alex Menezes dos , Filho Mario Francisco Dantas de Santana , Almeida-Santos Marcos Antonio , Rocha Raysa Manuelle Santos , Almeida Rebeca Rocha de , Baumworcel Leonardo , Costa Luiz Henrique Sala de Melo , Mendes Renata Rebello , Sousa Antônio Carlos Sobral
Published: April 2024

(1) Background: An elevated wrist circumference may indicate excess weight and cardiometabolic risk. The present study aims to identify wrist circumference cutoff points (WrC) to determine excess weight levels and predict cardiometabolic risk in adults. (2) Methods: A cross-sectional study was conducted with adults aged 20 to 59 years old, attending the outpatient clinic at University Hospital/Federal University of Sergipe HU/UFS-EBSERH. Demographic, anthropometric, biochemical, and blood pressure (BP) data were collected. Cardiometabolic risk was assessed, according to the global risk score (ERG) and Framingham score criteria. The descriptive analysis included calculating medians and frequencies of anthropometric, demographic, biochemical, and blood pressure variables. The gender and age of adult groups were compared using the Mann–Whitney test. Spearman’s correlation coefficient and multiple regression analysis were used to assess the association between wrist circumference (WrC) and the variables mentioned above. The predictive validity of WrC in identifying excess weight levels and cardiometabolic risk was analyzed using the ROC curve. The sample consisted of 1487 adults aged 20 to 59 years, 55.7% of whom were female; (3) Results: WrC correlated positively with other adiposity indicators such as waist circumference and Body Mass Index. WrC was the anthropometric indicator most significantly associated with cardiometabolic risk factors. WrC cutoff points identified by the study for determining excess weight were categorized by gender and age group. For males aged 20 to 40 years and >40 years, respectively, the cutoff points for overweight were 17.1 cm and 17.3 cm, and for obesity, 17.9 cm and 17.5 cm. For females aged 20 to 40 years and >40 years, respectively, the cutoff points for overweight were 15.6 cm and 15.4 cm, and for obesity, 16.1 cm and 16 cm (4). Conclusions: Wrist circumference showed a significant correlation with other adiposity indicators and can be used to identify adults with excess weight and predict cardiometabolic risk.
Investigating ESG Funds in China: Management Fees and Investment Performance
Authors: Wong Michael C. S. , Li Wei
Published: April 2024

This study investigates the association among management fees, ESG scores, and investment performance of ESG funds in China. It explores the significance of comprehending the cost–benefit analysis and long-term yields associated with sustainable investing. The investigation specifically concentrates on China’s open-end equity funds and uncovers some noteworthy discoveries. Initially, funds with higher management fees tend to yield greater returns, suggesting a potential validation for these fees. Nevertheless, when taking risk-adjusted metrics into account, these funds do not exhibit superior performance, indicating that the elevated fees may not necessarily result in enhanced performance after factoring in risk. Furthermore, the analysis discloses an adverse influence of ESG factors on fund performance. In general, the findings indicate that ESG funds in China do not impose higher management fees and do not ensure better returns but often produce superior risk-adjusted investment performance if their ESG scores are moderately higher. Exceptionally high ESG scores can end up with the worst risk-adjusted investment performance.
Do Invasive Jorō Spiders (Trichonephila clavata) from Asia Avoid Eating Unpalatable Monarch Butterflies (Danaus plexippus) in North America?
Authors: Davis Andrew K. , Morris Wilson Townsend , Hobbs Emma , Blakely Ella
Published: April 2024

An invasive spider from East Asia has established in the U.S. southeast (the “jorō spider,” Trichonephila clavata) and is rapidly expanding its range. Studies assessing the impact of this species are needed, including how expansive its diet is. An open question is whether monarch butterflies, Danaus plexippus, are a potential prey item for this spider, given that jorō spiders do not coexist with monarchs in their native range. Since monarch larvae feed on milkweed, they sequester cardiac glycosides into their adult tissues, rendering them unpalatable to many predators. At sites within northeast Georgia, we staged a series of trials (n = 61) where we tossed monarchs into jorō spider webs and, for comparison, performed similar trials with another aposematic species, gulf fritillary (Agraulis vanilla), and a palatable species, tiger swallowtail (Papilio glaucus). We recorded the outcome of the trials, which included whether the spider attacked or did not attack the prey. We also conducted a visual survey during the same fall season to look for evidence of jorō spiders consuming monarchs naturally. Our findings revealed that jorō spiders avoided eating monarchs; spiders only attacked monarchs 20% of the time, which was significantly less than the attack rates of similarly sized or larger butterflies: 86% for gulf fritillaries and 58% for tiger swallowtails. Some jorō spiders even removed monarchs from their webs. From our visual surveys of the surrounding area, we found no evidence of natural monarch consumption and, in general, butterflies made up only a fraction of the jorō spider diet. We conclude that jorō spiders appear to recognize monarch butterflies as being unpalatable, even without having a prior history with the species. This invokes questions about how these spiders can immediately recognize their unpalatability without touching the butterflies.
The Other Side of Chronic Venous Disorder: Gaining Insights from Patients’ Questions and Perspectives
Authors: Bissacco Daniele , Pisani Chiara
Published: April 2024

Venous disorders encompass a diverse range of manifestations and diseases, impacting a significant portion of the population. While life-threatening conditions are uncommon in non-thrombotic disorders, like telangiectasias or uncomplicated varicose veins (VVs), these conditions still have a substantial impact on affected individuals. Ensuring that patients are well informed about their venous disorder is a crucial step in their treatment journey. Providing them with valuable information regarding the disease’s natural progression and available therapeutic options plays a pivotal role in optimizing their care. When patients are diagnosed with venous disorders, they often have numerous questions and concerns they want to discuss with their healthcare providers. Addressing these inquiries not only improves patients’ knowledge and understanding but also influences their treatment compliance and overall outcomes. Therefore, it is of utmost importance to provide comprehensive explanations that address any doubts, uncertainties, and areas of confusion that patients may have. This report aims to present a concise, practical, and informative guide to venous disorders, focusing specifically on the common questions frequently raised by patients in everyday clinical practice. By serving as a valuable resource for healthcare professionals working in the field of venous diseases, this guide equips them with the necessary tools to effectively address patients’ concerns and provide optimal care. By bridging the gap between patients’ inquiries and medical expertise, this guide strives to enhance therapeutic outcomes and improve the overall management of venous disorders, ultimately empowering patients in their treatment journey.
Advanced Respiratory Monitoring during Extracorporeal Membrane Oxygenation
Authors: Simonte Rachele , Cammarota Gianmaria , Vetrugno Luigi , De Robertis Edoardo , Longhini Federico , Spadaro Savino
Published: April 2024

Advanced respiratory monitoring encompasses a diverse range of mini- or noninvasive tools used to evaluate various aspects of respiratory function in patients experiencing acute respiratory failure, including those requiring extracorporeal membrane oxygenation (ECMO) support. Among these techniques, key modalities include esophageal pressure measurement (including derived pressures), lung and respiratory muscle ultrasounds, electrical impedance tomography, the monitoring of diaphragm electrical activity, and assessment of flow index. These tools play a critical role in assessing essential parameters such as lung recruitment and overdistention, lung aeration and morphology, ventilation/perfusion distribution, inspiratory effort, respiratory drive, respiratory muscle contraction, and patient–ventilator synchrony. In contrast to conventional methods, advanced respiratory monitoring offers a deeper understanding of pathological changes in lung aeration caused by underlying diseases. Moreover, it allows for meticulous tracking of responses to therapeutic interventions, aiding in the development of personalized respiratory support strategies aimed at preserving lung function and respiratory muscle integrity. The integration of advanced respiratory monitoring represents a significant advancement in the clinical management of acute respiratory failure. It serves as a cornerstone in scenarios where treatment strategies rely on tailored approaches, empowering clinicians to make informed decisions about intervention selection and adjustment. By enabling real-time assessment and modification of respiratory support, advanced monitoring not only optimizes care for patients with acute respiratory distress syndrome but also contributes to improved outcomes and enhanced patient safety.
Clinical Genetic and Genomic Testing in Congenital Heart Disease and Cardiomyopathy
Authors: Pidaparti Mahati , Geddes Gabrielle C. , Durbin Matthew D.
Published: April 2024

Congenital heart disease (CHD) and cardiomyopathies are the leading cause of morbidity and mortality worldwide. These conditions are often caused by genetic factors, and recent research has shown that genetic and genomic testing can provide valuable information for patient care. By identifying genetic causes, healthcare providers can screen for other related health conditions, offer early interventions, estimate prognosis, select appropriate treatments, and assess the risk for family members. Genetic and genomic testing is now the standard of care in patients with CHD and cardiomyopathy. However, rapid advances in technology and greater availability of testing options have led to changes in recommendations for the most appropriate testing method. Several recent studies have investigated the utility of genetic testing in this changing landscape. This review summarizes the literature surrounding the clinical utility of genetic evaluation in patients with CHD and cardiomyopathy.
Stiffness Anisotropy and Micro-Mechanism of Calcareous Sand with Different Particle Breakage Ratios Subjected to Shearing Based on DEM Simulations
Authors: Gao Yan , Sun Ketian , Yuan Quan , Shi Tiangen
Published: April 2024

Stress-induced anisotropy in calcareous sand can cause an uneven displacement in island reef engineering. In this study, stiffness, as a quantitative indicator, is explored to reveal the stress-induced anisotropy in calcareous sand. Based on the discrete element method, the stiffness anisotropic characteristics of calcareous sand during shearing, as well as the impact of particle breakage, are investigated by numerical simulations. Both the macro and micro responses, i.e., the maximum shear modulus, contact normal, strong and weak contact normal force, and the direction of particle breakage, are explored for calcareous sand with different particle breakage ratios. The results show that calcareous sand exhibits notable anisotropy during shearing, with the maximum shear modulus in the vertical direction (deviatoric stress direction) being significantly greater than that in the horizontal direction. Moreover, the higher the particle breakage rate, the lower the stiffness and its anisotropy. The micro-mechanism results indicate that the primary particle breakage during the shearing process occurs in the vertical direction. That is, the particle breakage weakens the strong contact force in the vertical direction, leading to a redistribution of the strong contact forces from the vertical direction to other directions. This redistribution mainly manifests in a decrease in the anisotropy of contact normal and contact vector within the sample, as well as a decrease in the proportion of strong contact forces in the overall contacts. This, in turn, reduces the shear strength and stiffness of calcareous sand, particularly in the vertical direction, and results in a decrease in the maximum shear modulus and its anisotropy. The maximum reduction can be up to 50% of the original value. These insights can provide a certain theoretical support for the uneven displacement and long-term stability of calcareous sand for islands and reefs.
Multi-Frequency Noise Reduction Method for Underwater Radiated Noise of Autonomous Underwater Vehicles
Authors: Mao Beibei , Yang Hua , Li Wenbo , Zhu Xiaoyu , Zheng Yuxuan
Published: April 2024

The multi-frequency noisy vibration of an autonomous underwater vehicle (AUV) is a significant factor affecting the performance of shear probes mounted on the head of AUVs. Many efforts have been made to suppress mechanical radiation noise; however, conventional noise reduction methods have their limitations, such as mode mixing. In order to extract thorough information from the aliasing modes and achieve multi-frequency mode targeted correction, a multi-frequency noise reduction method is proposed, based on secondary decomposition and the multi-mode coherence correction algorithm. Weak impulses in aliasing shear mode are enhanced, and mixing frequencies are isolated for thorough decomposition. Noisy mechanical vibrations in the shear modes are eliminated with the use of the acceleration modes along the identical central frequency series. The denoised modes are used to reconstruct the cleaned shear signal, and the updated spectra are aligned with the standard Nasmyth spectrum. Compared with the raw profiles, the variation in the dissipation rate estimated from the corrected shear is reduced by more than an order of magnitude.
The Coastal Scenery of São Miguel Island, Azores Archipelago: Implications for Coastal Management
Authors: Tendero-Peiró Claudia , Asensio-Montesinos Francisco , Anfuso Giorgio , Corbí Hugo
Published: April 2024

In this study, coastal scenic beauty was assessed at 29 sites at São Miguel, which is one of the Azores Islands, i.e., a group of remote volcanic islands in the North Atlantic Ocean. The assessment was based on in situ observations and the use of the Coastal Scenic Evaluation System (CSES), which consists of a checklist with 26 physical- and anthropic-weighted parameters and the Fuzzy Logic Approach (FLA) mathematical tool. The study sites were classified into five classes according to their typology and their scenic value, ranging from Class I (natural sites of great scenic beauty) to Class V (unattractive, urbanized sites). Concerning beach typology, 13% were remote, 28% rural, 28% village, and 31% urban. Concerning scenic beauty, 10% of the sites belonged to Class I, 14% to Class II, 17% to Class III, 31% to Class IV, and 28% to Class V. The physical parameters were linked to the characteristics of the geological volcanic landscapes, and the anthropic parameters essentially reflected the presence of tourism and public services. The results of the assessment provide a scientific basis for developing a management strategy for the preservation and conservation of the coastal areas and their sustainable development.
Spacing Ratio Effects on the Evolution of the Flow Structure of Two Tandem Circular Cylinders in Proximity to a Wall
Authors: Qiu Xiang , Ji Xuezhi , Zhou Jiankang , Li Jiahua , Tao Yizhou , Liu Yulu
Published: April 2024

The flow around two tandem circular cylinders in proximity to a wall is investigated using particle image velocimetry (PIV) for Re = 2 × 103. The spacing ratios L/D are 1, 2, and 5, and the gap ratios G/D are 0.3, 0.6, and 1. The proper orthogonal decomposition (POD) method and λci vortex identification method are used to investigate the evolution of flow structure, and the influences of L/D and G/D on flow physics are shown. At L/D = 2 and G/D = 0.3, a “pairing” process occurs between the wall shear layer and the upstream cylinder’s lower shear layer, resulting in a small separation bubble behind the upstream cylinder. At L/D = 1, the Strouhal number (St) increases with decreasing G/D. At three gap ratios, the St gradually decreases as L/D increases. At G/D = 0.3, there is nearly a 49.98% decrease from St = 0.3295 at L/D = 1 to St = 0.1648 at L/D = 5, which is larger than the reductions in cases of G/D = 0.6 and G/D = 1. The effects of L/D on the evolution of flow structure at G/D = 0.6 are revealed in detail. At L/D = 1, the vortex shedding resembles that of the single cylinder. As L/D increases to 2, a squarish flow structure is formed between two cylinders, and a small secondary vortex is formed due to induction of the lower shear layer of the upstream cylinder. At L/D = 5, there is a vortex merging process between the upper wake vortices of the upstream and downstream cylinders, and the lower wake vortex of the upstream cylinder directly impinges the downstream cylinder. In addition, the shear layers and wake vortices of the upstream cylinder interact with the wake of the downstream cylinder as L/D increases, resulting in reductions in velocity fluctuations, and the production and turbulent diffusion of turbulent kinetic energy are decreased behind the downstream cylinder.
The Learning Curve for Pancreaticoduodenectomy: The Experience of a Single Surgeon
Authors: Cioltean Cristian Liviu , Bartoș Adrian , Muntean Lidia , Brânzilă Sandu , Iancu Ioana , Pojoga Cristina , Breazu Caius , Cornel Iancu
Published: April 2024

Background and Aims: Pancreaticoduodenectomy (PD) is a complex and high-skill demanding procedure often associated with significant morbidity and mortality. However, the results have improved over the past two decades. However, there is a paucity of research concerning the learning curve for PD. Our aim was to report the outcomes of 100 consecutive PDs representing a single surgeon’s learning curve and to depict the factors that influenced the learning process. Methods: We reviewed the first 121 PDs performed at our academic center (2013–2019) by a single surgeon; 110 were PDs (5 laparoscopic and 105 open) and 11 were total PDs (1 laparoscopic and 10 open). Subsequent statistics was performed on the first 100 PDs, with attention paid to the learning curve and survival rate at 5 years. The data were analyzed comparing the first 50 cases (Group 1) to the last 50 cases (Group 2). Results: The most frequent histopathological tumor type was pancreatic ductal adenocarcinoma (50%). A total of 39% of patients had preoperative biliary drainage and 45% presented with positive biliary cultures. The preferred reconstruction technique included pancreaticogastrostomy (99%), in situ hepaticojejunostomy (70%), and precolic gastro-jejunal anastomosis (88%). Postoperative complications included biliary fistula (1%), pancreatic fistula (8%), pancreatic stump bleeding (4%), and delayed gastric emptying (13%). The mean operative time decreased after the first 50 cases (p < 0.001) and blood loss after 60 cases (p = 0.046). R1 resections lowered after 25 cases (p = 0.025). Vascular resections (17%) did not influence the rate of complications (p = 0.8). The survival rate at 5 years for pancreatic adenocarcinoma was 32.93%. Conclusions: Outcomes improve as surgeon experience increases, with proper training being the most important factor for minimizing the impact of the learning curve over the postoperative complications. Analyzing the learning curve from the perspective of a single surgeon is mandatory for accurate statistical results and interpretation.
Influence of Laser Treatment of Ti6Al4V on the Behavior of Biological Cells
Authors: Syrovatka Simon , Kozmin Pavel , Holesovsky Frantisek , Sorm Martin
Published: April 2024

This article explores the enhancement of material surface properties of Ti6Al4V, potentially applicable to dental implants, through ultra-short pulse laser systems. This study investigates potential connections between surface wettability and biocompatibility, addressing the challenge of improving variability in material properties with specific laser treatment. Several designed microstructures were manufactured using a picosecond laser system. After that, the wettability of these structures was measured using the sessile drop method. The basic behavior and growth activity of biological cells (MG-63 cell line) on treated surfaces were also analyzed. While the conducted tests did not conclusively establish correlations between wettability and biocompatibility, the results indicated that laser treatment of Ti6Al4V could effectively enlarge the active surface to better biological cell colonization and adhesion and provide a focused moving orientation. This outcome suggests the potential application of laser treatment in producing special dental implants to mitigate the issues during and following implantation.
Mathematical Modeling of the Displacement of a Light-Fuel Self-Moving Automobile with an On-Board Liquid Crystal Elastomer Propulsion Device
Authors: Qiu Yunlong , Chen Jiajing , Dai Yuntong , Zhou Lin , Yu Yong , Li Kai
Published: April 2024

The achievement and control of desired motions in active machines often involves precise manipulation of artificial muscles in a distributed and sequential manner, which poses significant challenges. A novel motion control strategy based on self-oscillation in active machines offers distinctive benefits, such as direct energy harvesting from the ambient environment and the elimination of complex controllers. Drawing inspiration from automobiles, a self-moving automobile designed for operation under steady illumination is developed, comprising two wheels and a liquid crystal elastomer fiber. To explore the dynamic behavior of this self-moving automobile under steady illumination, a nonlinear theoretical model is proposed, integrating with the established dynamic liquid crystal elastomer model. Numerical simulations are conducted using the Runge-Kutta method based on MATLAB software, and it is observed that the automobile undergoes a supercritical Hopf bifurcation, transitioning from a static state to a self-moving state. The sustained periodic self-moving is facilitated by the interplay between light energy and damping dissipation. Furthermore, the conditions under which the Hopf bifurcation occurs are analyzed in detail. It is worth noting that increasing the light intensity or decreasing rolling resistance coefficient can improve the self-moving average velocity. The innovative design of the self-moving automobile offers advantages such as not requiring an independent power source, possessing a simple structure, and being sustainable. These characteristics make it highly promising for a range of applications including actuators, soft robotics, energy harvesting, and more.
Intellectual Capital Evaluation Index Based on a Hybrid Multi-Criteria Decision-Making Technique
Authors: Liu Chao , Liao Qichen , Gao Wenyan , Li Shuxian , Jiang Peng , Li Ding
Published: April 2024

In the context of a burgeoning knowledge economy, enterprise intellectual capital has emerged as a pivotal asset for organizational growth. Evaluating it requires a comprehensive and robust index, yet there is no standard methodology for such assessments. Here, we propose an index for evaluating enterprise intellectual capital. We use the Delphi method to delineate a scientific decision structure. A grey-based decision-making trial and evaluation laboratory (DEMATEL) is coupled with an analytic network process (ANP)—i.e., grey DEMATEL-based ANP (GDANP)—to determine the relative weight of indicators. Then, we use the technique for order preference by similarity to an ideal solution to validate the effectiveness and applicability of the proposed evaluation index based on data on thirty new-technology companies in China. This study bridges a critical gap in academic discourse, and we discuss the practical implications for the strategic management of intellectual capital in corporate settings.
Revolutionary Strategy for Depicting Knowledge Graphs with Temporal Attributes
Authors: Li Sihan , Li Qi
Published: April 2024

In practical applications, the temporal completeness of knowledge graphs is of great importance. However, previous studies have mostly focused on static knowledge graphs, generally neglecting the dynamic evolutionary properties of facts. Moreover, the unpredictable and limited availability of temporal knowledge graphs, together with the complex temporal dependency patterns, make current models inadequate for effectively describing facts that experience temporal transitions. To better represent the evolution of things over time, we provide a learning technique that uses quaternion rotation to describe temporal knowledge graphs. This technique describes the evolution of entities as a temporal rotation change in quaternion space. Compared to the Ermitian inner product in complex number space, the Hamiltonian product in quaternion space is better at showing how things might be connected. This leads to a learning process that is both more effective and more articulate. Experimental results demonstrate that our learning method significantly outperforms existing methods in capturing the dynamic evolution of temporal knowledge graphs, with improved accuracy and robustness across a range of benchmark datasets.
Fast Eigenvalue Decomposition of Arrowhead and Diagonal-Plus-Rank-k Matrices of Quaternions
Authors: Chaysri Thaniporn , Jakovčević Stor Nevena , Slapničar Ivan
Published: April 2024

Quaternions are a non-commutative associative number system that extends complex numbers, first described by Hamilton in 1843. We present algorithms for solving the eigenvalue problem for arrowhead and DPRk (diagonal-plus-rank-k) matrices of quaternions. The algorithms use the Rayleigh Quotient Iteration with double shifts (RQIds), Wielandt’s deflation technique and the fact that each eigenvector can be computed in O(n) operations. The algorithms require O(n2) floating-point operations, n being the order of the matrix. The algorithms are backward stable in the standard sense and compare well to the standard QR method in terms of speed and accuracy. The algorithms are elegantly implemented in Julia, using its polymorphism feature.
Recent Trends in Adipose Tissue-Derived Injectable Therapies for Osteoarthritis: A Scoping Review of Animal Models
Authors: Adam Alina Otilia , Benea Horea Rares Ciprian , Fotescu Horia Mihnea , Alcalá Ruiz Miriam , Cimpean George Claudiu , Ciornei Vladimir , Cernacovschi Arsenii , Edves Andrei Rares , Crisan Maria
Published: April 2024

Background and Objectives: This scoping review investigates recent trends in adipose tissue-derived injectable therapies for osteoarthritis (OA) in animal models, focusing on minimally manipulated or lightly processed adipose tissue. By evaluating and examining the specific context in which these therapies were investigated across diverse animal OA models, this review aims to provide valuable insights that will inform and guide future research and clinical applications in the ongoing pursuit of effective treatments for osteoarthritis. Materials and Methods: This research conducted a comprehensive literature review of PubMed and Embase to determine studies about minimally manipulated adipose tissue-derived injectable therapies for osteoarthritis investigated using animal models. The primary search found 530 results. After excluding articles that focused on spontaneous osteoarthritis; on transfected, preconditioned, cultured, or co-cultured adipose-derived stem cells; and articles with unavailable full text, we included 11 articles in our review. Results: The examined therapies encompassed mechanical micro-fragmented adipose tissue (MFAT) and stromal vascular fraction (SVF) obtained via collagenase digestion and centrifugation. These interventions were evaluated across various animal models, including mice, rats, rabbits, and sheep with induced OA. Notably, more studies concentrated on surgically induced OA rather than chemically induced OA. The assessment of these therapies focused on elucidating their protective immunomodulatory, anti-inflammatory, and chondroregenerative potential through comprehensive evaluations, including macroscopic assessments, histological analyses, immunohistochemical examinations, and biochemical assays. Conclusions: This review provides a comprehensive analysis of adipose tissue-derived injectable therapies for osteoarthritis across diverse animal models. While revealing potential benefits and insights, the heterogeneity of data and the limited number of studies highlight the need for further research to formulate conclusive recommendations for clinical applications.
The Influence of Aging Precipitates on the Mechanical Properties of Al–Li Alloys and Microstructural Analysis
Authors: Li Ganghui , Xiao Wei , Li Xiwu , Wen Kai , Gao Guanjun , Yan Lizhen , Li Yanan , Yan Hongwei , Zhang Yongan , Wang Xingquan , Xiong Baiqing
Published: April 2024

In this work, the evolution of mechanical properties of binary Al–Li alloys with four approximately equal gradient Li contents (0.91–3.98 wt.%) under aging conditions is thoroughly investigated. The alloys undergo aging treatments at 175 °C for x hours (x = 0–120 h), and the peak-aged times of the four alloys are 6 h, 12 h, 48 h and 48 h, respectively, as the Li concentration increases. Both in the solution-treated and peak-aged states, the elastic modulus of binary Al–Li alloys exhibits an approximately linear increase with increasing Li content, consistent with trends predicted by density functional theory (DFT) calculations. Due to the presence of Al3Li precipitates, the modulus of higher-Li-concentration alloys in the peak-aged state increases by approximately 1.4–2.5% compared with that of alloys in the solution-treated state. Additionally, the study finds that increasing Li content significantly enhances the tensile strength and yield strength of the alloy but decreases its ductility, leading to a transition in fracture mode from ductile to brittle, as evidenced by a microscopic analysis of fracture surfaces. Under peak-aged (175 °C/48 h), the alloy with the highest Li content exhibits the maximum tensile strength of 341 MPa and a yield strength of 296 MPa, while its elongation is the lowest at 2.1%. These findings contribute to a deeper understanding of the effects of aging precipitates on the mechanical properties of Al–Li alloys, providing fundamental guidance for the design of future generations of Al–Li alloys.
Modeling Metallic Fatigue Data Using the Birnbaum–Saunders Distribution
Authors: Sawlan Zaid , Scavino Marco , Tempone Raúl
Published: April 2024

This work employs the Birnbaum–Saunders distribution to model the fatigue-life of metallic materials under cyclic loading and compares it with the normal distribution. Fatigue-limit models are fitted to three datasets of unnotched specimens of 75S-T6 aluminum alloys and carbon laminate with different loading types. A new equivalent stress definition that accounts for the effect of the experiment type is proposed. The results show that the Birnbaum–Saunders distribution consistently outperforms the normal distribution in fitting the fatigue data and provides more accurate predictions of fatigue-life and survival probability.
Nutritional Profiles and Their Links to Insulin Resistance and Anthropometric Variables in a Female Cohort
Authors: Wiśniewska-Ślepaczuk Katarzyna , Żak-Kowalska Karolina , Moskal Adrian , Kowalski Sebastian , Al-Wathinani Ahmed M. , Alhajlah Mousa , Goniewicz Krzysztof , Goniewicz Mariusz
Published: April 2024

This study investigates the relationship between dietary habits and metabolic health among women, emphasizing the role of anthropometric parameters as proxies for insulin resistance. We analyzed data from 443 women categorized into two groups based on the presence or absence of clinically diagnosed insulin resistance. Our assessments included dietary quality, socio-demographic characteristics, and a series of anthropometric measurements such as body weight, Body Mass Index (BMI), Waist-Hip Ratio (WHR), Abdominal Volume Index (AVI), and Body Adiposity Index (BAI). The results indicated significant disparities in these parameters, with the insulin-resistant group exhibiting higher average body weight (78.92 kg vs. 65.04 kg, p < 0.001), BMI (28.45 kg/m2 vs. 23.17 kg/m2, p < 0.001), and other related measures, suggesting a strong influence of dietary patterns on body composition and metabolic risk. The study underscores the importance of dietary management in addressing insulin resistance, advocating for personalized dietary strategies to improve metabolic health outcomes in women. This approach highlights the need for integrating dietary changes with lifestyle modifications and socio-demographic considerations to combat metabolic risks effectively.
Growing Trend to Adopt Speckle Variance Optical Coherence Tomography for Biological Tissue Assessments in Pre-Clinical Applications
Authors: Wijesinghe Ruchire Eranga , Kahatapitiya Nipun Shantha , Lee Changho , Han Sangyeob , Kim Shinheon , Saleah Sm Abu , Seong Daewoon , Silva Bhagya Nathali , Wijenayake Udaya , Ravichandran Naresh Kumar , Jeon Mansik , Kim Jeehyun
Published: April 2024

Speckle patterns are a generic feature in coherent imaging techniques like optical coherence tomography (OCT). Although speckles are granular like noise texture, which degrades the image, they carry information that can be benefited by processing and thereby furnishing crucial information of sample structures, which can serve to provide significant important structural details of samples in in vivo longitudinal pre-clinical monitoring and assessments. Since the motions of tissue molecules are indicated through speckle patterns, speckle variance OCT (SV-OCT) can be well-utilized for quantitative assessments of speckle variance (SV) in biological tissues. SV-OCT has been acknowledged as a promising method for mapping microvasculature in transverse-directional blood vessels with high resolution in micrometers in both the transverse and depth directions. The fundamental scope of this article reviews the state-of-the-art and clinical benefits of SV-OCT to assess biological tissues for pre-clinical applications. In particular, focus on precise quantifications of in vivo vascular response, therapy assessments, and real-time temporal vascular effects of SV-OCT are primarily emphasized. Finally, SV-OCT-incorporating pre-clinical techniques with high potential are presented for future biomedical applications.
Effect of Deposition Pressure and Temperature on Tungsten Thin-Film Heater for Phase-Change Switch Applications
Authors: Qu Sheng , Zhang Jihua , Gao Libin , Chen Hongwei , Ding Yao
Published: April 2024

Tungsten (W) film is increasingly utilized in various microheater applications due to its numerous advantages. These advantages include a high melting point, positive constant temperature coefficient of resistance (TCR), good mechanical stability, and compatibility with semiconductor processes. In this paper, deposition parameters for enhancing the properties of W film were investigated, and an optimized microheater was fabricated. It was found that the deposition temperature and pressure can modify the TCR to be negative or positive and the crystalline phase of W films to be alpha phases or mixed with beta phases. A W film deposited under 650 °C with a pressure of 1 pa has a positive TCR and pure alpha phase crystalline structure. We applied this optimized W film as a microheater in an RF phase-change switch (RFPCS), and the maximum voltage of the optimized W microheater increased by at least 48% in this work. By optimizing the microheater, the phase-change switch can be successfully actuated in both on and off states, demonstrated by the Raman results of the phase-change material. A voltage pulse of 20 V/200 ns was enough to turn the switch off with MΩ, and 11 V/3 μs could turn the switch on with 138 Ω. The optimized microheater and device can cycle 500 times without failure. The insertion loss and isolation of the device at 20 GHz was 1.0 dB and 22 dB.