bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical Outcomes of Conservative Surgery for Diffuse Uterine Leiomyomatosis: Preliminary Experience of 17 Cases in a Single Center
Authors: Kweon Sojung , Park Joowon , Sim Youngseo , Kwack Jae Young , Kwon Yong-Soon
Published: December 2023

This study aimed to introduce the clinical outcomes of conservative surgery for diffuse uterine leiomyomatosis, which also included the specialized surgical technique. All patients with diffuse uterine leiomyomatosis underwent conservative surgery such as transient occlusion of the uterine arteries (TOUA) adenomyomectomy. All 17 surgeries were performed by a single surgeon between 2018 and 2021. The mean age of the 17 patients was 36.12 years old (range 29–48, SD = 5.4). Fourteen of the 17 patients received a previous myomectomy via a laparotomic (6, 35.3%), laparoscopic (6, 35.3%), or hysteroscopic (2, 11.8%) approach. The major symptom was menorrhagia (94.1%); the mean operation time was 97.06 min (70–160, SD = 22.71), and the mean estimated blood loss was 283.53 mL (20–1000, SD = 273.72). The mean hemoglobin level one day after the operation was 9.64 g/dL (7.2–13.1, SD = 1.85). The mean hospital stay was 6.47 days (6–8, SD = 0.62). The mean follow-up duration was 116.41 weeks (32–216, SD = 50.88). The recurrence rate was 5/17 (29.4%), and the recurrence-free interval was 50.6 weeks (27–87, SD = 23.71). In patients with diffuse uterine leiomyomatosis, who want fertility preservation and relief of disease-related symptoms, conservative surgery such as TOUA adenomyomectomy could be a good option to preserve the uterus. However, further studies are required to assess fertility outcomes with a long-term follow-up.
Association between Gray and White Matter Lesions and Its Involvement in Clinical Symptoms of Alzheimer’s-Type Dementia
Authors: Nakase Taizen , Thyreau Benjamin , Tatewaki Yasuko , Tomita Naoki , Takano Yumi , Muranaka Michiho , Taki Yasuyuki
Published: December 2023

Background: Not only gray matter lesions (GMLs) but also white matter lesions (WMLs) can play important roles in the pathology of Alzheimer’s disease (AD). The progression of cognitive impairment (CI) and behavioral and psychological symptoms of dementia (BPSD) might be caused by a concerted effect of both GML and WML. Objective: This study aimed to investigate the association between GML and WML and how they are involved in the symptoms of CI and BPSD in dementia patients by means of imaging technology. Methods: Patients in our memory clinic, who were diagnosed with AD-type dementia or amnestic mild cognitive impairment (aMCI) and had undergone both single-photon emission computed tomography (SPECT) and brain MRI, were consecutively enrolled (n = 156; 61 males and 95 females; 79.8 ± 7.4 years old). Symptoms of CI and BPSD were obtained from patients’ medical records. For the analysis of GMLs and WMLs, SPECT data and MRI T1-weighted images were used, respectively. This study followed the Declaration of Helsinki, and all procedures were approved by the institutional ethics committee. Results: According to a multivariate analysis, disorientation and disturbed attention demonstrated a relationship between the precuneus and WMLs in both hemispheres. Hyperactivity in BPSD showed multiple correlations between GMLs on both sides of the frontal cortex and WMLs. Patients with aMCI presented more multiple correlations between GMLs and WMLs compared with those with AD-type dementia regarding dementia symptoms including BPSD. Conclusion: The interaction between GMLs and WMLs may vary depending on the symptoms of CI and BPSD. Hyperactivity in BPSD may be affected by the functional relationship between GMLs and WMLs in the left and right hemispheres. The correlation between GMLs and WMLs may be changing in AD-type dementia and aMCI.
New Perspective for Using Antimicrobial and Cell-Penetrating Peptides to Increase Efficacy of Antineoplastic 5-FU in Cancer Cells
Authors: Vale Nuno , Ribeiro Eduarda , Cruz Inês , Stulberg Valentina , Koksch Beate , Costa Bárbara
Published: December 2023

This study explores the effectiveness of the antineoplastic agent 5-FU in cancer cells by leveraging the unique properties of cationic antimicrobial peptides (CAMPs) and cell-penetrating peptides (CPPs). Traditional anticancer therapies face substantial limitations, including unfavorable pharmacokinetic profiles and inadequate specificity for tumor sites. These drawbacks often necessitate higher therapeutic agent doses, leading to severe toxicity in normal cells and adverse side effects. Peptides have emerged as promising carriers for targeted drug delivery, with their ability to selectively deliver therapeutics to cells expressing specific receptors. This enhances intracellular drug delivery, minimizes drug resistance, and reduces toxicity. In this research, we comprehensively evaluate the ADMET (absorption, distribution, metabolism, excretion, and toxicity) properties of various AMPs and CPPs to gain insights into their potential as anticancer agents. The peptide synthesis involved a solid-phase synthesis using a Liberty Microwave Peptide Synthesizer. The peptide purity was confirmed via LC-MS and HPLC methods. For the ADMET screening, computational tools were employed, assessing parameters like absorption, distribution, metabolism, excretion, and toxicity. The cell lines A549 and UM-UC-5 were cultured and treated with 5-FU, CAMPs, and CPPs. The cell viability was measured using the MTT assay. The physicochemical properties analysis revealed favorable drug-likeness attributes. The peptides exhibited potential inhibitory activity against CYP3A4. The ADMET predictions indicated variable absorption and distribution characteristics. Furthermore, we assessed the effectiveness of these peptides alone and in combination with 5-FU, a widely used antineoplastic agent, in two distinct cancer cell lines, UM-UC-5 and A549. Our findings indicate that CAMPs can significantly reduce the cell viability in A549 cells, while CPPs exhibit promising results in UM-UC-5 cells. Understanding these multifaceted effects could open new avenues for antiviral and anticancer research. Further, experimental validation is necessary to confirm the mechanism of action of these peptides, especially in combination with 5-FU.
Transcriptomic and Proteomic Insights into the Effect of Sterigmatocystin on Aspergillus flavus
Authors: Zhao Yarong , Zeng Rui , Chen Peirong , Huang Chulan , Xu Kaihang , Huang Xiaomei , Wang Xu
Published: December 2023

Aspergillus flavus is an important fungus that produces aflatoxins, among which aflatoxin B1 (AFB1) is the most toxic and contaminates food and poses a high risk to human health. AFB1 interacts with another mycotoxin sterigmatocystin (STC), which is also a precursor of AFB1. Herein, we determined the effect of STC on AFB1 by evaluating A. flavus transcriptomic and proteomic profiles in the presence or absence of STC by RNA-seq and isobaric tagging, respectively. Overall, 3377 differentially expressed genes were identified by RNA-seq. These genes were mainly associated with the cellular component organisation and biosynthesis, the synthesis of valine, leucine, and isoleucine, and the synthesis of aflatoxin. Clustered genes responsible for AFB1 biosynthesis exhibited varying degrees of downregulation, and norB expression was completely suppressed in the experimental group. During proteomic analysis, 331 genes were differentially expressed in response to STC. These differentially expressed proteins were associated with cell parts and catalytic and antioxidant activities. Differentially expressed proteins predominantly participated in metabolic pathways associated with aflatoxin biosynthesis, glycolysis/gluconeogenesis, glutathione metabolism, and carbon metabolism. Notably, the upregulated and downregulated enzymes in carbohydrate and glutathione metabolisms may serve as potential gateways for inhibiting aflatoxin biosynthesis. Moreover, twelve proteins including seven downregulated ones involved in aflatoxin biosynthesis were identified; among them, AflG was the most downregulated, suggesting that it may be the key enzyme responsible for inhibiting aflatoxin synthesis. These findings provide novel insights into A. flavus control and the mechanisms regulating mycotoxin production.
Chronological Changes in Sagittal Femoral Bowing after Primary Cementless Total Hip Arthroplasty: A Comparative 3D CT Study
Authors: Pardo Francesco , La Mattina Antonino Amedeo , Diquattro Emanuele , Lucchini Stefano , Viceconti Marco , Minerba Andrea , Castagnini Francesco , Traina Francesco
Published: December 2023

Little is known about dynamic changes of femoral anatomy after total hip arthroplasty (THA), in particular about sagittal femoral bowing (SFB). A 3D CT study was designed to evaluate the chronological changes of SFB after cementless femoral stem implantation for primary THA. Ten patients who underwent unilateral primary THA with a cementless femoral stem, with 2 consecutive CT scans (extending from the fourth lumbar vertebra to the tibial plateaus), performed before THA and at least 3 years after THA, were enrolled. The 3D models of femurs were created using image segmentation software. Using the two CT scans, SFB values of the proximal and middle thirds were calculated on the replaced and untreated sides by two different observers. Eight anatomical stems and two conical stems were involved. The post-operative CT was performed at an average follow-up of 6.5 years after THA (range: 3–12.5). The measurements performed by the two observers did not differ in the proximal and middle regions. A significant difference between the pre-operative and post-operative SFB compared to the untreated side was found in the proximal femur segment (p = 0.004). Use of a cementless stem in THA induced chronological changes in SFB of the proximal femur, after a minimum timespan of 3 years.
The Effect of Papyrus Wetlands on Flow Regulation in a Tropical River Catchment
Authors: Oyarmoi Alem , Birkinshaw Stephen , Hewett Caspar J. M. , Fowler Hayley J.
Published: December 2023

Africa has the largest area of wetlands of international importance, and papyrus constitutes the most dominant species for many of these wetlands. This hydrological modelling study assesses and quantifies the impacts of these papyrus wetlands on historical baseflow and quickflow, as well as future flood and low flows in the Mpologoma catchment in Uganda. Assessment over the historic period shows that wetlands strongly attenuate quickflow while moderately enhancing baseflow. They play a moderating role in most months, except for the first dry season (June and July), due to the reversal of flows between wetlands and rivers that often occur during this period. Annual estimates show that wetlands are four times better at regulating quickflow than baseflow. Examination of changes at 2 and 4 °C global warming levels (GWLs) indicate that wetlands will play critical roles in mitigating flood risks, with a lesser role in supporting low flows. Wetlands are predicted to lower future mean flood magnitude by 5.2 and 7.8% at GWL2 and GWL4, respectively, as well as halving the average number of flood events in a year, irrespective of the warming level. This work shows that papyrus-dominated wetlands strongly influence catchment hydrology, with significant roles on quickflow, including floods, and highlights the need for their conservation and protection.
An Anisotropic Peridynamic Model for Simulating Crack Propagation in Isotropic and Anisotropic Rocks
Authors: Tian Kaiwei , Zhu Zeqi , Sheng Qian , Tian Ning
Published: December 2023

In this work, we present a peridynamic-based simulation method for modeling quasi-static fracture propagation in isotropic and anisotropic rock within the framework of peridynamic least square minimization (PDLSM). The original isotropic elastic PDLSM is further extended to investigate fracture propagation in anisotropic materials in this study. The proposed AN-PDLSM model integrates an anisotropic model in fracture mechanics to analyze the failure process of anisotropic rocks. An important advancement in this research lies in the incorporation of the maximum energy release rate criterion (MERR) into the PDLSM framework for the first time. This enhancement enables accurately determining crack propagation and the associated crack angles. The proposed model utilizes the energy release rate calculated through the J-integral method to assess bond breakage, and it employs a mesh-independent, piecewise linear fracture model to describe crack propagation. The proposed method fully combines the merits of traditional fracture mechanics with the unique capabilities of peridynamics. To demonstrate the effectiveness of the proposed model, a simulation of fracture evolution in isotropic plates subjected to semi-circular bending tests is presented and compared with experimental results. It is shown that the proposed model accurately replicates fracture trajectories in isotropic specimens. In the context of anisotropic rock, the effect of a weak coefficient on crack morphology is discussed in order to obtain a suitable value. Additionally, the impact of bedding angles on fracture paths through our proposed model is also explored, revealing excellent agreement with experimental results. The findings in this research demonstrate that the proposed AN-PDLSM model is exceptionally proficient at capturing the intricate, oscillating crack paths observed in anisotropic rock materials.
Effective Stabilization of Cadmium and Copper in Iron-Rich Laterite-Based Geopolymers and Influence on Physical Properties
Authors: Nkwaju Rachel Yanou , Nouping Joëlle Nadia Fekoua , Bachirou Soumayah , Abo Tatiane Marina , Deutou Juvenal Giogetti Nemaleu , Djobo Jean Noël Yankwa
Published: December 2023

This study aimed to investigate the efficiency of a geopolymer binder of the type of Na-poly(ferro–silico–aluminate) as a matrix for the stabilization of heavy metals along with their effect on the development of structural performances. The artificial contamination of soil with ions was carried out and used to prepare an alkali-activated iron-rich lateritic soil binder. Further, various microstructural analyses were carried out to explain the stabilization mechanism. The stabilization efficiency was assessed by leaching tests in de-ionized water and hydrochloric acid (0.1 M, HCl). Then, the physical properties were determined to evaluate the impact of heavy metals on the structural performance of the binder. Results demonstrated that the prepared geopolymer binder has the lowest stabilization capacity in an acidic medium (low pH) than in water with high pH. However, the stabilization of Cu ions was effective at 99%, while the Cd ion is barely retained in the matrix. Firstly, the mechanism consists of chemical bonds through ion exchange with sodium of the Na-poly(ferro–silico–aluminate) network. Secondly, through physical interaction with the pore network of the matrix, the heavy metals induced structural deterioration in the geopolymer matrix with a decrease in the compressive strength and bulk density and an increase of both apparent porosity and water absorption.
Research on Cold Roll Forming Process of Strips for Truss Rods for Space Construction
Authors: Yang Xingwen , Han Jingtao , Lu Ruilong
Published: December 2023

In this paper, a new technology for on-orbit cold forming of space truss rods is proposed. For the cold roll forming process of asymmetric cross sections of thin strips, the effects of roll gap and roll spacing on the forming of asymmetric cross sections of strips were investigated using ABAQUS simulation + experiments. The study shows the following. When forming a strip with a specific asymmetric cross section, the stresses are mainly concentrated in corners 2/4/6, with the largest strain value in corner 2. With increasing forming passes, when the roll gap is 0.3 mm, the maximum equivalent strain values are 0.09, 0.24, 0.64 sequentially. Roll gaps of 0.4 mm and 0.5 mm equivalent strain change amplitude are relatively similar, and their maximum equivalent strain values are approximately 0.07,0.15, 0.44. From the analysis of the stress–strain history of the characteristic nodes in corners 2/4/6, it can be seen that the stress and strain changes in the deformation process mainly occur at the moment of interaction between the upper and lower rollers, where the stress type of node 55786 shows two tensile types and one compressive type, the stress type of nodes 48594 and 15928 shows two compressive and one tensile type, and the strain of the three nodes is in accordance with the characteristics of plane strain. When the roll gap is about 0.4 mm, the forming of the strip is relatively good. With increased roll spacing, the strip in the longitudinal stress peak through the rollers shows a small incremental trend, but the peak stresses are 380 Mpa or so. When the roll spacing is 120 mm, the longitudinal strain fluctuation of the strip is the most serious, followed by the roll spacing at 100 mm, and the minimum at 140 mm. Combined with the fluctuation in strip edges under different roll spacings, manufacturing cost and volume and other factors, a roll spacing of 100 mm is more reasonable. It is experimentally verified that when the roll gap is 0.4 mm and the roll spacing is 100 mm, the strip is successfully prepared in accordance with the cross-section requirements. When the rolling gap is 0.3 mm, due to stress–strain concentration, the strip is prone to edge waves in forming. The top of corner 2 of the flange triangular region is susceptible to intermittent tear defects, and the crack extension mechanism is mainly based on the cleavage fracture + ductile fracture.
Degradation of Azo Dye Solutions by a Nanocrystalline Fe-Based Alloy and the Adsorption of Their By-Products by Cork
Authors: Ben Mbarek Wael , Issa Maher , Salvadó Victoria , Escoda Lluisa , Khitouni Mohamed , Suñol Joan-Josep
Published: December 2023

In this study, the efficiency of mechanically alloyed Fe80Si10B10 in degrading basic red 46 azo dye is investigated. Moreover, the influences of different parameters, such as pH and time, on the elimination of the aromatic derivatives obtained as by-products of the fracture of the azo group are also analyzed. After beginning the reduction to the normal conditions of pH (4.6) and temperature, the experimental findings showed a discoloration of 97.87% after 20 min. The structure and morphology of the nanocrystalline Fe80Si10B10 powder were characterized by SEM and XRD before and after use in the degradation process. The XRD patterns of the Fe–Si–B powder after redox reaction suggest that the valent zero Fe of the alloy is the reducing agent. Powdered cork was then used as a biosorbent for the removal of the by-products generated, resulting in increasing removal percentages from pH 7 (26%) to pH 9 (62%) and a contact time of 120 min. The FTIR spectrum of the cork after adsorption shows a shift of the bands, confirming the interaction with the aromatic amines. The present findings show that metallic powders and natural cork perform well together in removing azo dye solutions and their degradation products.
Enzymolytic Lignin-Derived N-S Codoped Porous Carbon Nanocomposites as Electrocatalysts for Oxygen Reduction Reactions
Authors: Li Zheng , Qu Xia , Feng Yuwei , Dong Lili , Yang Yantao , Lei Tingzhou , Ren Suxia
Published: December 2023

Currently, the development of nonmetallic oxygen reduction reaction (ORR) catalysts based on heteroatomic-doped carbon materials is receiving increaseing attention in the field of fuel cells. Here, we used enzymolytic lignin (EL), melamine, and thiourea as carbon, nitrogen, and sulfur sources and NH4Cl as an activator to prepare N- and S-codoped lignin-based polyporous carbon (ELC) by one-step pyrolysis. The prepared lignin-derived biocarbon material (ELC-1-900) possessed a high specific surface area (844 m2 g−1), abundant mesoporous structure, and a large pore volume (0.587 cm3 g−1). The XPS results showed that ELC-1-900 was successfully doped with N and S. ELC-1-900 exhibited extremely high activity and stability in alkaline media for the ORR, with a half-wave potential (E1/2 = 0.88 V) and starting potential (Eonset = 0.98 V) superior to those of Pt/C catalysts and most non-noble-metal catalysts reported in recent studies. In addition, ELC-1-900 showed better ORR stability and methanol tolerance in alkaline media than commercial Pt/C catalysts.
Special Issue: “Advanced Light Metal and Alloys: Preparation, Characterization, and Applications”
Authors: Liu Pingping
Published: December 2023

This Special Issue presents fundamental and applied research in advanced light metal and alloys [...]
Inner Surface Morphology and Roughness Evolution of Pilgering Thick-Walled Tubes
Authors: Li Ran , Jin Pengfei , Wang Weijie , Zhang Cheng , Du Xingwu , Huang Jinfeng
Published: December 2023

A hot-working die steel thick-walled tube Pilger rolling test was carried out using an LG40 Pilger mill, and the morphology and roughness evolution of the inner surface were examined using a white-light interferometer. The experimental results showed that micro-wrinkles formed on the basis of the original inner surface morphology, the altitude difference (Sz) between the peaks and valleys of the inner surface profile increased from 3.18 to 3.686 μm, and Sa increased from 0.722 to 0.892 μm in the diameter reduction zone. As the tube continued to feed into the wall thickness reduction zone, the micro-wrinkles gradually flattened, Sz and Sa were decreased to 1.625 and 0.174 respectively, and Sa maintained a slight fluctuation of 0.174~0.2 μm in the final sizing zone. From the diameters of the roller groove and taper of the mandrel, the three-dimensional strain of the tube in the wall thickness reduction zone was calculated, and the strain state of the tube in the complete deformation zone could be analyzed by finite element simulations. We found that in the diameter reduction zone, the inner surface was not supported by the mandrel and was free, while micro-wrinkles formed under circumferential compressive strain. In the wall thickness reduction zone, the deformation of the inner surface was controlled by the mandrel, and the micro-wrinkles were gradually flattened by radial compressive strain. The ratio of radial to circumferential strain was the key to flattening the micro-wrinkles, and when the ratio increased, the inner surface roughness (Sa) was reduced to 0.174 μm. In the sizing zone, the radial and circumferential strains were small, and the inner surface roughness showed no obvious fluctuation.
Mechanical Properties and Water Permeability of Textile-Reinforced Reactive Powder Concrete with Lightweight Aggregate
Authors: Różycki Marcin , Hager Izabela , Zdeb Tomasz , Sitarz Mateusz , Mróz Katarzyna , Zdeb Jarosław , Smorońska Natalia
Published: December 2023

This paper focuses on the development of thin-walled panels with specific properties for applications such as water-tight structures. The authors propose the use of textile-reinforced concrete (TRC) as a composite material and highlight its advantages, which include high tensile strength, improved crack resistance, and design flexibility. The study presents a novel approach which combines TRC with reactive powder concrete (RPC) as a matrix and a lightweight aggregate. RPC, known for its brittle behaviour, is reinforced with glass fibres and a textile fabric to increase its flexural strength. The research includes a comprehensive analysis of the physical and mechanical properties of both the unreinforced RPC matrix and the TRC composite. In particular, the lightweight aggregate RPC matrix has a porosity of 41%, and its mechanical properties, such as flexural and compressive strength, are discussed. The TRC composites, produced in thicknesses ranging from 1 mm to 4 mm, are subjected to flexural tests to evaluate their behaviour under load. The thicker elements show typical damage phases, while the thinner elements show greater flexibility and elasticity. SEM observations confirm good adhesion between the glass fibres and the RPC matrix. Water permeability tests show that the TRC composite, despite its highly porous structure, achieves a water permeability two orders of magnitude higher than that of a reference material, highlighting the roles of both the porous aggregate and the matrix hydration. The paper concludes with a proof of concept—a canoe called the PKanoe, which is constructed from the developed TRC composite. The design of the canoe is supported by numerical analysis to ensure its optimal shape and structural integrity under load. The research contributes to the exploration of innovative materials for sustainable civil engineering applications and addresses both structural and environmental considerations.
The Salmon Oil OmeGo Reduces Viability of Colorectal Cancer Cells and Potentiates the Anti-Cancer Effect of 5-FU
Authors: Pettersen Caroline H. H. , Samdal Helle , Sætrom Pål , Wibe Arne , Hermansen Erland , Schønberg Svanhild A.
Published: December 2023

Colorectal cancer (CRC) is one of the most common cancer types worldwide. Chemotherapy is toxic to normal cells, and combinatory treatment with natural well-tolerated products is being explored. Some omega-3 polyunsaturated fatty acids (n-3 PUFAs) and marine fish oils have anti-cancer effects on CRC cells. The salmon oil OmeGo (Hofseth BioCare) contains a spectrum of fatty acids, including the n-3 PUFAs docosahexaenoic acid (DHA) and eicosahexaenoic acid (EPA). We explored a potential anti-cancer effect of OmeGo on the four CRC cell lines DLD-1, HCT-8, LS411N, and LS513, alone and in combination with the chemotherapeutic agent 5-Fluorouracil (5-FU). Screening indicated a time- and dose-dependent effect of OmeGo on the viability of the DLD-1 and LS513 CRC cell lines. Treatment with 5-FU and OmeGo (IC20–IC30) alone indicated a significant reduction in viability. A combinatory treatment with OmeGo and 5-FU resulted in a further reduction in viability in DLD-1 and LS513 cells. Treatment of CRC cells with DHA + EPA in a concentration corresponding to the content in OmeGo alone or combined with 5-FU significantly reduced viability of all four CRC cell lines tested. The lowest concentration of OmeGo reduced viability to a higher degree both alone and in combination with 5-FU compared to the corresponding concentrations of DHA + EPA in three of the cell lines. Results suggest that a combination of OmeGo and 5-FU could have a potential as an alternative anti-cancer therapy for patients with CRC.
Effects of Sheared Edge and Overlap Length on Reduction in Tensile Fatigue Limit before and after Hydrogen Embrittlement of Resistance Spot-Welded Ultra-High-Strength Steel Sheets
Authors: Yagita Ryo , Abe Yohei
Published: December 2023

The effects of a sheared edge and overlap length on the reduction in the tensile fatigue limit before and after hydrogen embrittlement of resistance spot-welded ultra-high-strength steel sheets were investigated. Ultra-high-strength steel sheets with sheared and laser-cut edges were subjected to resistance spot welding followed by hydrogen embrittlement via cathodic hydrogen charging and subjected to static tensile shear and fatigue tests. The distance between the resistance spot weld and the sheared and laser-cut edges was changed by changing the overlap length, and the influence of the weld position was investigated. In the tensile shear test, the maximum load decreased with decreasing overlap length and the maximum load decreased with hydrogen embrittlement, but the effect of hydrogen embrittlement was smaller than that in the fatigue test. In the fatigue test, the fatigue mode changed from the width direction to the sheared edge direction with the increase in the repeated load. Even if the overlap length was reduced, the fracture changed to the sheared edge direction. In the specimens with sheared edges, the effect of fatigue limit reduction due to hydrogen embrittlement was greater than in the specimens with laser surfaces. In particular, the effect was greatest when the fatigue mode was changed via hydrogen embrittlement.
Analysis of Face-Centered Cubic Phase in Additively Manufactured Commercially Pure Ti
Authors: Adams Claire L. , Field David P.
Published: December 2023

Metal additive manufacturing is a developing technique with numerous advantages and challenges to overcome. As with all manufacturing techniques, the specific raw materials and processing parameters used have a profound influence on microstructures and the resulting behavior of materials. It is important to understand the relationship between processing and microstructures of Ti to advance knowledge of Ti-alloys in the additive field. In this study, a face-centered cubic (FCC) phase was found in grade 2 commercially pure titanium specimens, additively manufactured with directed energy deposition in an argon atmosphere. Two scanning speeds (500 and 1000 mm/min) and three scanning patterns (cross-hatched and unidirectional patterns) were investigated. Electron backscatter diffraction and energy-dispersive X-ray spectroscopy were used for microstructural and compositional analysis. Inverse pole figure, phase, and kernel average misorientation (KAM) maps were analyzed in this work. Larger amounts of the FCC phase were found in the unidirectional scanning patterns for the slower scanning speed, while the cross-hatched pattern for both scanning speeds showed a lower amount of FCC. Higher KAM averages were present in the faster scanning speed specimens. According to EDS scans, small amounts of nitrogen were uniformly distributed throughout the specimens, leading to the possibility of interstitial content as a contributing factor for development of the observed FCC phase. However, there is no clear relationship between nitrogen and the FCC phase. The formation of this FCC phase could be connected to high densities of crystalline defects from processing, plastic deformation, or the distribution of interstitials in the AM structure. An unexpected Kurdjumow–Sachs-type orientation relationship between the parent beta phase and FCC phase was found, as 110BCC∥111FCC, 111BCC∥110FCC.
Research Progress on Ultra-Low Temperature Steels: A Review on Their Composition, Microstructure, and Mechanical Properties
Authors: Xiong Jianchao , Zhang Xiaodan , Wang Yuhui
Published: December 2023

To address global environmental concerns and reduce carbon dioxide emissions, countries worldwide are prioritizing the development of green, eco-friendly, and low-carbon energy sources. This emphasis has led to the growing importance of promoting clean energy industries like hydrogen energy and natural gas. These gases are typically stored and transported at cryogenic temperatures, making ultra-low temperature alloys indispensable as essential materials for the storage and transportation of liquid gas energy. With the temperature decreasing from room temperature (RT) to liquid nitrogen temperature (LNT), the dominant deformation mechanism in high-manganese steels undergoes a transformation from dislocation slip to deformation twinning, resulting in exceptional cryogenic mechanical properties. Consequently, high-manganese steel has emerged as an excellent material candidate for cryogenic applications. This report focuses on establishing the composition of high-manganese steel suitable for cryogenic applications and provides a comprehensive review of its microstructure and mechanical properties at both RT and LNT. Furthermore, it offers a prospective outlook on the future development of cryogenic high-manganese steels.
Determinant of Dynamics and Interfacial Forces in Ultraprecision Machining of Optical Freeform Surface through Simulation-Based Analysis
Authors: Khaghani Ali , Ivanov Atanas , Cheng Kai
Published: December 2023

This study delves into the intricacies of ultraprecision machining, particularly in the context of machining optical freeform surfaces using Diamond Turning Machines (DTMs). It underscores the dynamic relationship between toolpath generation, hydrostatic bearing in DTMs, and the machining process. Central to this research is the innovative introduction of Metal Matrix Composites (MMCs) to replace the traditional materials used in designing linear bearings. This strategic substitution aims to dynamically enhance both the accuracy and the quality of the machined optical freeform surfaces. The study employs simulation-based analysis using ADAMS to investigate the interfacial cutting forces at the tooltip and workpiece surface and their impacts on the machining process. Through simulations of STS mode ultraprecision machining, the interfacial cutting forces and their relationship with changes in surface curvatures are examined. The results demonstrate that the use of MMC material leads to a significant reduction in toolpath pressure, highlighting the potential benefits of employing lightweight materials in improving the dynamic performance of the system. Additionally, the analysis of slideway joints reveals the direct influence of interfacial cutting forces on the linear slideways, emphasising the importance of understanding and controlling these forces for achieving higher-precision positioning and motion control. The comparative analysis between steel and MMC materials provides valuable insights into the effects of material properties on the system’s dynamic performance. These findings contribute to the existing body of knowledge and suggest a potential shift towards more advanced precision forms, possibly extending to pico-engineering in future systems. Ultimately, this research establishes a new standard in the field, emphasising the importance of system dynamics and interfacial forces in the evolution of precision manufacturing technologies.
Dynamic Compressive Properties and Failure Mechanism of the Laser Powder Bed Fusion of Submicro-LaB6 Reinforced Ti-Based Composites
Authors: Li Xianghui , Liu Yang
Published: December 2023

In this study, lanthanum hexaboride (LaB6) particle-reinforced titanium matrix composites (PRTMCs, TC4/LaB6) were successfully manufactured using the laser powder bed fusion (LPBF) process. Thereafter, the effect of the mass fraction of LaB6 on the microstructure and the dynamic compressive properties was investigated. The results show that the addition of LaB6 leads to significant grain refinement. Moreover, the general trend of grain size reveals a concave bend as the fraction increases from 0.2% to 1.0%. Furthermore, the texture intensity of prior β grains and α grains was found to be weakened in the composites. It was also observed that the TC4/LaB6 have higher quasi-static and dynamic compressive strengths but lower fracture strain when compared with the as-built TC4. The sample with 0.5 wt.% LaB6 was found to have the best strength–toughness synergy among the three groups of composites due to having the smallest grain size. Furthermore, the fracture mode of TC4/LaB6 was found to change from the fracture under the combined action of brittle and ductility to the cleavage fracture. This study was able to provide a theoretical basis for an in-depth understanding of the compressive properties of additive manufacturing of PRTMCs under high-speed loading conditions.
Achieving Luminescence of Sr3Ga1.98In0.02Ge4O14:0.03Cr3+ via [In3+] Substitution [Ga3+] and Its Application to NIR pc-LED in Non-Destructive Testing
Authors: Wang Tao , Gao Bingkai , Li Jiehong , Wang Zhijun , Li Panlai
Published: December 2023

Cr3+-doped Sr3Ga2Ge4O14:0.03Cr3+ (SGGO:0.03Cr3+) phosphor was synthesized via a high-temperature solid-phase method. Considering the tunable structure of SGGO, Ga3+ ions in the matrix were substituted with In3+ ions at a certain concentration. The tuned phosphor produced a red-shifted emission spectrum, with its luminescence intensity at 423 K maintained at 63% of that at room temperature; moreover, the internal quantum efficiency increased to 65.60%, and the external quantum efficiency correspondingly increased to 21.94%. On this basis, SGIGO:0.03Cr3+ was encapsulated into a pc-LED, which was applied in non-destructive testing (NDT) experiments, successfully realizing the recognition of water and anhydrous ethanol, proving its potential application in the field of NDT.
Recent Progress in CDK4/6 Inhibitors and PROTACs
Authors: Wang Hao , Ba Jianfei , Kang Yue , Gong Zeqiao , Liang Tingting , Zhang Yahong , Qi Jianguo , Wang Jianhong
Published: December 2023

Cell division in eukaryotes is a highly regulated process that is critical to the life of a cell. Dysregulated cell proliferation, often driven by anomalies in cell Cyclin-dependent kinase (CDK) activation, is a key pathological mechanism in cancer. Recently, selective CDK4/6 inhibitors have shown clinical success, particularly in treating advanced-stage estrogen receptor (ER)-positive and human epidermal growth factor receptor 2 (HER2)-negative breast cancer. This review provides an in-depth analysis of the action mechanism and recent advancements in CDK4/6 inhibitors, categorizing them based on their structural characteristics and origins. Furthermore, it explores proteolysis targeting chimers (PROTACs) targeting CDK4/6. We hope that this review could be of benefit for further research on CDK4/6 inhibitors and PROTACs.
Ag Nanoparticles and Rod-Shaped AgCl Decorated Porous PEDOT as a Bifunctional Material for Hydrogen Evolution Catalyst and Supercapacitor Electrode
Authors: Zhang Chunyong , Wang Haoyu , Shu Li , Li Zhe , Bai Jirong , Wen Yinpin , Zhu Lin , Geng Yin , Qin Hengfei
Published: December 2023

PEDOT-Ag/AgCl is a highly promising material with dual functions of hydrogen evolution reaction (HER) and supercapacitors. In this study, a simple low-temperature stirring and light irradiation method was used to synthesize PEDOT-Ag/AgCl on the surface. Then, PEDOT-Ag/AgCl was analyzed using X-ray diffraction, scanning electron microscopy, X-ray photoelectron spectroscopy, and transmission electron microscopy. PEDOT-Ag/AgCl reacted in 1 M KOH alkaline electrolyte with an overpotential of 157 mV at 20 mA·cm−2 and a Tafel slope of 66.95 mv·dec−1. Owing to the synergistic effect of PEDOT and Ag/AgCl, this material had a small resistance (1.7 Ω) and a large specific capacitance (978 F·g−1 at current density of 0.5 A·g−1). The synthesis method can prepare nanostructured PEDOT with uniformly-distributed Ag nanoparticles and rod-shaped AgCl on the surface, which can be used as both HER electrocatalysts and supercapacitor electrodes.
In Situ Incorporation of Atomically Precise Au Nanoclusters within Zeolites for Ambient Temperature CO Oxidation
Authors: Tesana Siriluck , Kennedy John V. , Yip Alex C. K. , Golovko Vladimir B.
Published: December 2023

Preserving ultrasmall sizes of metal particles is a key challenge in the study of heterogeneous metal-based catalysis. Confining the ultrasmall metal clusters in a well-defined crystalline porous zeolite has emerged as a promising approach to stabilize these metal species. Successful encapsulation can be achieved by the addition of ligated metal complexes to zeolite synthesis gel before hydrothermal synthesis. However, controlling the metal particle size during post-reduction treatment remains a major challenge in this approach. Herein, an in situ incorporation strategy of pre-made atomically precise gold clusters within Na-LTA zeolite was established for the first time. With the assistance of mercaptosilane ligands, the gold clusters were successfully incorporated within the Na-LTA without premature precipitation and metal aggregation during the synthesis. We have demonstrated that the confinement of gold clusters within the zeolite framework offers high stability against sintering, leading to superior CO oxidation catalytic performance (up to 12 h at 30 °C, with a space velocity of 3000 mL g−1 h−1).
Synthesis of ZnFe2O4 Nanospheres with Tunable Morphology for Lithium Storage
Authors: Volkov Filipp S. , Kamenskii Mikhail A. , Tolstopjatova Elena G. , Voskanyan Lusine A. , Bobrysheva Natalia P. , Osmolovskaya Olga M. , Eliseeva Svetlana N.
Published: December 2023

ZnFe2O4 (ZFO) nanospheres with complex structures have been synthesized by a one-step simple solvothermal method using two different types of precursors—metal chlorides and nitrates —and were fully characterized by XRD, SEM, XPS, and EDS. The ZFO nanospheres synthesized from chloride salts (ZFO_C) were loose with a size range of 100–200 nm, while the ZFO nanospheres synthesized from nitrate salts (ZFO_N) were dense with a size range of 300–500 nm but consisted of smaller nanoplates. The different morphologies may be caused by the different hydrolysis rates and different stabilizing effects of chloride and nitrate ions interacting with the facets of forming nanoparticles. Electrochemical tests of nitrate-based ZFO nanospheres as anode materials for lithium-ion batteries demonstrated their higher cyclic stability. The ZFO_C and ZFO_N samples have initial specific discharge/charge capacities of 1354/1020 and 1357/954 mAh∙g−1, respectively, with coulombic efficiencies of 75% and 71%. By the 100th cycle, ZFO_N has a capacity of 276 mAh∙g−1, and for ZFO_C, only 210 mAh∙g−1 remains after 100 cycles.
In-Hospital Formula Feeding Hindered Exclusive Breastfeeding: Breastfeeding Self-Efficacy as a Mediating Factor
Authors: Liu Lu , Wu Yuju , Xian Xiannan , Feng Jieyuan , Mao Yuping , Balakrishnan Siva , Weber Ann M. , Darmstadt Gary L. , Chen Yunwei , Sylvia Sean , Zhou Huan , Rozelle Scott
Published: December 2023

Breastfeeding self-efficacy (BSE), defined as a mother’s confidence in her ability to breastfeed, has been confirmed to predict the uptake of exclusive breastfeeding (EBF). Early experiences during the birth hospital stay, especially in-hospital formula feeding (IHFF), can impact both EBF and maternal breastfeeding confidence. Therefore, our objective was to examine the association between IHFF and EBF outcomes and investigate whether this association is influenced by BSE. The study included 778 infants from a larger cohort study conducted in 2021, with a one-year follow-up in rural areas of Sichuan Province, China. We used a causal mediation analysis to estimate the total effect (TE), natural direct (NDE), and nature indirect effects (NIE) using the paramed command in Stata. Causal mediation analyses revealed that IHFF was negatively associated with EBF (TE odds ratio = 0.47; 95% CI, 0.29 to 0.76); 28% of this association was mediated by BSE. In the subgroup analysis, there were no significant differences in the effects between parity subgroups, as well as between infant delivery subgroups. Our study found that IHFF hindered later EBF and that BSE mediated this association. Limiting the occurrence of in-hospital formula feeding or improving maternal breastfeeding self-efficacy is likely to improve exclusive breastfeeding outcomes.
Association between Masticatory Performance, Nutritional Intake, and Frailty in Japanese Older Adults
Authors: Okada Mitsuzumi , Hama Yohei , Futatsuya Ryota , Sasaki Yoshiyuki , Noritake Kanako , Yamaguchi Kohei , Matsuzaki Mayuko , Kubota Chieko , Hosoda Akemi , Minakuchi Shunsuke
Published: December 2023

The older adult population in Japan is expected to increase. Therefore, long-term care and frailty prevention are important. However, the relationship between masticatory performance, nutritional intake, and frailty remains unclear. This cross-sectional study aimed to examine energy, protein, and vitamin D intake and its association with frailty and masticatory performance in older adults. Patients between January 2022 and January 2023 were recruited and divided into robust and frail groups. Masticatory performance, nutrition, frailty, and other data, such as age and sex, were evaluated through onsite measurements and a questionnaire. Logistic regression analysis was conducted with frailty as a dependent variable and masticatory performance as an independent variable, adjusting for age, sex, skeletal muscle mass, living alone, energy intake, protein–energy ratio, and vitamin D intake. No significant differences were observed between the groups regarding age or sex. The robust group showed significantly better results for protein–energy ratio, vitamin D intake, and subjective and objective masticatory performance than the frail group. Logistic regression analysis revealed a significant correlation between skeletal muscle mass, protein–energy ratio, and objective masticatory performance with frailty. Masticatory performance was associated with frailty, independent of the intake of nutrients such as energy, protein, and vitamin D.
Measuring Sodium from Discretionary Salt: Comparison of Methods
Authors: McLean Rachael Mira , Wang Nan Xin , Cameron Claire , Skeaff Sheila
Published: December 2023

(1) Background: The best method to assess discretionary salt intake in population surveys has not been established. (2) Methods: This secondary analysis compared three different methods of measuring sodium intake from discretionary salt in a convenience sample of 109 adults in New Zealand. Participants replaced their household salt with lithium-tagged salt provided by researchers over eight days. Baseline 24 h urine was collected, and two further 24 h urine and 24 h dietary recalls were collected between days six and eight. Discretionary salt was estimated from the lithium-tagged salt, focused questions in the 24 h dietary recall, and the ‘subtraction method’ (a combination of 24 h urine and 24 h dietary recall measures). (3) Results: Around one-third of estimates from the ‘subtraction method’ were negative and therefore unrealistic. The mean difference between 24 h dietary recall and lithium-tagged salt estimates for sodium from discretionary salt mean were 457 mg sodium/day and 65 mg/day for mean and median, respectively. (4) Conclusions: It is possible to obtain a reasonable estimate of discretionary salt intake from careful questioning regarding salt used in cooking, in recipes, and at the table during a 24 h recall process to inform population salt reduction strategies.
Dynamics of Serologic Change to Gluten in Celiac Disease Patients
Authors: Syage Jack , Ramos Ana , Loskutov Vasiliy , Norum Anna , Bledsoe Adam , Choung Rok Seon , Dickason Matthew , Sealey-Voyksner Jennifer , Murray Joseph
Published: December 2023

Serologic measures of tissue transglutaminase (tTG) immunoglobulin A (IgA) and deamidated gliadin peptide (DGP) IgA and immunoglobulin G (IgG) are hallmark tests utilized when diagnosing individuals for celiac disease (CeD) and for monitoring adherence to a gluten-free diet (GFD), currently the only available treatment for CeD. We address two issues in this study: (i) the relapse to seropositivity for CeD patients who resume a gluten containing diet and (ii) the correlation between two different tTG-IgA assays near the upper limit of normal (ULN) designated thresholds. Regarding the first issue, often a suspected CeD individual is put back on a gluten diet to return to their serologic levels. However, we show it requires a substantial amount of gluten for serology to return to a positive level. For example, in one study of 22 patients treated with placebo and taking 84 g of gluten over 6 weeks, only two converted from seronegative to seropositive for tTG-IgA. Regarding the second topic, we compare the relationship for different serologic assays, namely tTG-IgA AB (recombinant, ULN = 4 units/mL) vs. tTG-IgA (non-recombinant, ULN = 20 units). There is a strong correlation between both measurements as evidenced by a Pearson coefficient of R = 0.8584; however, we observed that the cross-correlation in terms of sensitivity and specificity improved substantially by using an ULN value of three instead of four for the tTG-IgA AB (recombinant) assay. This result suggests that assay thresholds used for initial diagnosis in patients who have not yet started a GFD may need to be adjusted for monitoring and in the setting of a diagnostic gluten challenge.