bluuebunny/crossref_metadata_2025 huggingface dataset:
MANEJO DA ASMA EM CRIANÇAS: DIAGNÓSTICO E TRATAMENTO NO CONTEXTO EMERGENCIAL
Authors: Aquino de Sousa Parreira Abreu Yasmin , Jayme Ávilla Ingrid , Araújo Fernandes Marcela , Martins Tostes Letícia , Luca de Oliveira Yan , Henrique Simões Arthur , Cardoso Guimarães Marília , Carvalho Martins Georgiton , Borges Vieira Luiza , Larissa Reis Fernandes Sarah , Lazzari Branquinho Paula , De Barros Schuab Jürgen , Pereira Ferreira Jennifer , Novaes Carvalho Luiza
Published: August 2024

A asma é uma condição crônica prevalente em crianças, caracterizada por obstrução das vias aéreas e sintomas como sibilância e dispneia. Este estudo revisa o manejo da asma em pediatria, especialmente no contexto emergencial, abordando aspectos diagnósticos e terapêuticos. O diagnóstico da asma requer uma anamnese detalhada, exame físico completo e testes de função pulmonar. Embora o diagnóstico seja essencialmente clínico, ferramentas como espirometria e avaliação do Pico de Fluxo Expiratório (PFE) são cruciais para avaliar a gravidade da doença.
No contexto de crises agudas de asma, o tratamento envolve a administração rápida de beta-2 agonistas de curta ação e corticosteroides, além de medidas de suporte respiratório, como oxigênio. A metilprednisolona é destacada como um corticosteroide eficaz quando administrado precocemente, enquanto o sulfato de magnésio intravenoso é indicado para casos graves com resposta inadequada ao tratamento inicial. Além do manejo farmacológico, é fundamental fornecer educação aos pacientes e suas famílias sobre o uso correto de dispositivos inalatórios e a adesão ao tratamento para prevenir futuras exacerbações. O estudo ressalta a importância de um diagnóstico preciso e de intervenções terapêuticas imediatas e eficazes para melhorar os desfechos clínicos em crianças com asma, especialmente em situações de emergência. A abordagem sistemática apresentada oferece uma base para otimizar a prática clínica e reduzir a morbidade associada à asma em pediatria.
ORIENTAÇÕES DE HIGIENE E MANUTENÇÃO DA PRÓTESE SOBRE IMPLANTE: UMA REVISÃO INTEGRATIVA DA LITERATURA
Authors: Souto Dayanne Gabriele da Silva , Silva Andressa Joselma Santiago da , Barboza Anne Beatriz de Brito , Ribeiro Carlos Eduardo Nunes , Martins Gabriela Maria dos Santos , Dantas Letícia Karolliny , Pimentel Luiz Felipe Martins da Silva , Silva Marcos Antônio de Souza , Alves Midian Santos , Santos Rafaella Juliana Bezerra dos , Lins Sócrates de França , Pereira Thayná Ramos , Bezerra Addler Filipe da Cruz
Published: August 2024

A evolução dos princípios de osseointegração têm permitido que as próteses sobre implante se transformem em uma opção rotineira de tratamento para pacientes edêntulos. A prótese nada mais é do que um equipamento que visa devolver função, estética e forma ao órgão dental perdido. Entretanto, para que a prótese tenha sua longevidade preservada, faz-se necessária a prática de higiene oral, das manutenções e controles periódicos. A falta de conhecimento acerca da higienização adequada das próteses pelo paciente ou seu cuidador tem-se mostrado uma problemática que resulta na diminuição da vida útil das mesmas, e comumente está associado ao surgimento de doenças infecciosas e inflamações da mucosa oral. O presente trabalho, mantém foco numa revisão integrativa da literatura acerca da higiene e manutenção da prótese sobre implante. Trata-se de uma pesquisa bibliográfica realizada através das bases de dados científicos como PUBMED, LILACS e BVS no período de agosto a setembro de 2024. Foram selecionados 299 artigos em português, inglês, e espanhol publicados entre 2014 e 2024, dos quais 10 foram incluídos para o estudo relacionados.  As próteses fixas sobre implante são consideradas a primeira opção de reabilitação de pacientes desdentados. A higienização e a manutenção dessas próteses são importantes para que haja durabilidade da peça. Os principais materiais usados na higienização são: escovas dentais; escovas interdentais; fio dental; irrigador oral; creme dental; e, enxaguatórios bucais. A conduta clínica do cirurgião-dentista nesses casos interfere potencialmente no posicionamento do paciente ou cuidador quanto à correta higiene oral. As instruções corretas melhoram o prognóstico das próteses. Desta forma, destaca-se a importância da higiene e manutenção da prótese sobre implante, bem como o impacto das orientações do cirurgião-dentista.
Diretrizes atuais para o tratamento da lesão renal aguda
Authors: Ribeiro Victoria , Fonseca Fernandes João Henrique , Santo Pessoa Victória , Rolins Costa Luis Fernando , Da Silva Borges Célio Roberto , Moreira Queiroz Sarah , De Moura Sousa Ítalo , da Silva Araujo Thayse , Soares Guimarães Lucas , Fortuna Kalil de Faria Ivan Aurélio , Freitas Ribeiro Elissandra , Gonçalves Calixto Bruno
Published: August 2024

Este artigo visa revisar e analisar as diretrizes atuais para o tratamento da lesão renal aguda, utilizando a base de dados PubMed com os termos "Injúria Renal Aguda”, “Diretrizes Clínicas” e "Tratamento". Em síntese, a revisão das diretrizes atuais para o tratamento da lesão renal aguda (LRA) revela avanços significativos na detecção e manejo da condição. A incorporação de novas tecnologias como biomarcadores e técnicas de imagem avançadas, tem permitido uma identificação mais precoce e precisa da LRA, possibilitando intervenções mais rápidas e eficazes. O uso de biomarcadores como cistatina C e NGAL tem mostrado um potencial promissor na melhoria da detecção precoce e na redução da progressão da doença. Adicionalmente, a abordagem personalizada no manejo da LRA, com ênfase na otimização da perfusão renal e na correção de desequilíbrios hemodinâmicos, tem se mostrado essencial para a eficácia do tratamento e para a prevenção de complicações. A introdução de terapias de suporte renal, como a diálise, continua a ser crucial para casos graves de LRA, com as diretrizes atuais recomendando modalidades contínuas ou intermitentes conforme a gravidade e condição clínica do paciente. Além disso, a exploração de novos agentes farmacológicos e terapias emergentes, como a terapia com células-tronco, oferece perspectivas promissoras para o tratamento e a recuperação renal. Apesar dos avanços, é necessário continuar a pesquisa para confirmar a eficácia a longo prazo e para aperfeiçoar as práticas de tratamento. A combinação dessas abordagens pode contribuir significativamente para a melhoria dos desfechos clínicos e para o avanço na gestão da lesão renal aguda.
Efeitos adversos do uso prolongado de glicocorticóides
Authors: Franco Nascimento Caroline , De Oliveira Silva Ingrid , Cruz Magalhães Thainá , Gastaldelo Victoria , Maria de Souza Oliveira Júlia , Cristine Marini Danyelle
Published: August 2024

O cortisol é um hormônio sintetizado no córtex da glândula adrenal, que afetam o metabolismo dos carboidratos e reduzem a resposta inflamatória. Os glicocorticóides são derivados sintéticos deste hormônio, com algumas mudanças e alterações para aumentar sua ação, função e eficiência no organismo humano. O objetivo do presente trabalho foi identificar o uso indiscriminado e prolongado dos medicamentos glicocorticóides, verificar as consequências causadas pelo efeito adverso do medicamento, doenças relacionadas e desenvolvidas. A pesquisa foi realizada por meio de questionário que foi disponibilizado para voluntários por meio da plataforma Google Forms. O link para acesso de voluntários ao questionário foi disponibilizado via e-mail e redes sociais, com participação de pessoas com mais de 18 anos. Durante a pesquisa foram analisados 76 pacientes, onde 39 faziam o uso de medicamento contínuo (51,3%) e 36 não faziam o uso de medicamento contínuo (47,4%). A amostra avaliada foi composta por 61 (80,3%) mulheres e 15 (19,7%) homens. No qual refere-se às idades dos participantes entre 18 a 59 anos. Os efeitos adversos apresentados entre os pacientes variam, mas de acordo com a maioria são: dores de cabeça, insônia, cansaço, agitação e nível da pressão arterial elevada, entre outros.  Conclui-se que o uso dos glicocorticóides causa muitos efeitos adversos, através do presente estudo é constatado que o uso dos glicocorticóides, têm sido controlados pelos entrevistados e orientados pelos prescritores de alguma forma.
A influência da microbiota vaginal na saúde reprodutiva feminina
Authors: Dutra Thiago Guedes Assis , Takahashi Eduardo Hideki , Cavalcante Dhara Rodrigues , Santos João Pedro Barros Rodrigues , Rêgo Maria Clara Raulino , Gouvea Ana Luiza Viana , Silva Mathws Rodrigues da , Belfort Wanessa Cândida Queiroz , Simão Salma Sarkis , Matos Letícia Mello , Oliveira Filho João Edilson de , Carrijo Vinícius Silva
Published: August 2024

A microbiota vaginal desempenha um papel central na saúde reprodutiva feminina, influenciando diretamente a fertilidade, o sucesso gestacional e a prevenção de complicações reprodutivas. Dominada por bactérias do gênero Lactobacillus, essa microbiota mantém um ambiente vaginal ácido que protege contra patógenos e favorece a sobrevivência dos espermatozoides e a receptividade endometrial. A disbiose, caracterizada pela redução de Lactobacillus e aumento de bactérias anaeróbicas, está associada a infertilidade, abortos espontâneos, parto prematuro e outras complicações gestacionais. Estudos indicam que intervenções como o uso de probióticos específicos podem restaurar o equilíbrio microbiano, melhorando os desfechos reprodutivos. Além disso, a composição da microbiota vaginal pode influenciar a resposta imunológica local e sistêmica, tendo implicações na saúde integral feminina. A avaliação regular da microbiota vaginal deve ser incorporada nos cuidados pré-concepcionais e gestacionais, possibilitando intervenções preventivas personalizadas. No entanto, há limitações nos estudos existentes, como a variabilidade metodológica e a falta de pesquisas longitudinais, que precisam ser abordadas em futuras investigações. A integração da análise da microbiota vaginal na prática clínica pode revolucionar o manejo das complicações reprodutivas, promovendo um cuidado mais eficaz e individualizado. Com a crescente compreensão da importância da microbiota vaginal, novos tratamentos personalizados e o uso de tecnologias avançadas, como a metagenômica, abrem caminho para melhorias significativas na saúde reprodutiva feminina.
TRATAMENTO CIRÚRGICO DA INCONTINÊNCIA URINÁRIA DE ESFORÇO NAS MULHERES
Authors: Ferreira Thiago Araujo , Barroso da Silva Mateus de Grise , Gomes Natiele da Silva , Morais Lourenço Ana Carolina , Reis Sousa Tayla Ramille dos , Reis Viana Naiara Pereira dos , Soria Laura Veiga , Soares Venturim Rebeca Kanawati , Catuladeira Nascimento Rafael Maciel , Morais Matheus Torquato
Published: August 2024

A incontinência urinária de esforço (IUE) é uma condição onde há perda involuntária da urina pelo meato uretral, durante um episódio de esforço, como, por exemplo, em um episódio de espirro, tosse ou esforço físico. Essa condição interfere na qualidade de vida das mulheres. O tratamento é dividido em dois eixos, sendo um relacionado ao tratamento conservador e outro o tratamento cirúrgico. O objetivo do trabalho é analisar a importância do tratamento cirúrgico na incontinência urinária de esforço. Trata-se de uma revisão narrativa dos últimos 5 anos, do período de 2019 a 2024, com a base de dados: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), Secretaria Municipal de Saúde de São Paulo e Medline. Os descritores utilizados foram: "incontinencia" "urinaria" "esforço" "tratamento" "cirurgico". Além disso, utilizou-se um documento de ginecologia. Evidenciou-se que o tratamento cirúrgico nessa condição apresenta bons resultados, podendo ser utilizado como primeira opção de tratamento. A realização do tratamento é importante não só para correção da perda urinária, como também para melhorar a qualidade de vida da mulher. O sling retropúbico apresenta uma boa taxa de cura a longo prazo. O sling transobturador tem uma elevada taxa de cura e menos chance de lesão uretral e da bexiga. Atualmente há estudos sobre o uso de mini-slings ou slings de incisão única para o tratamento dessa condição. Nessa perspectiva, nota-se a importância do tratamento cirúrgico como efeito curativo e melhora da qualidade de vida da mulher.
USO DOS INIBIDORES SELETIVOS DE RECAPTAÇÃO DE SEROTONINA NO TRATAMENTO DA DEPRESSÃO
Authors: Inácio Volpe Lucas Américo , Peixoto Leandro de Freitas , Cândido Fernandes Ana Edilza , Mascarenhas Martins Diana Dárlym , Gomes Monteiro Ana Paula , Barroso da Silva Mateus de Grise , Condé Morais Maria Eduarda , Dos Santos Duarte Geovana Mancini , Catuladeira Nascimento Rafael Maciel , Xavier Andrade Plácido Marília Gabriela
Published: August 2024

O transtorno depressivo maior é uma condição neuropsiquiátrica que está relacionado ao mau humor persistente e perda de prazer para realização de atividades diárias, além da possibilidade de outros sintomas como alterações no peso, sentimentos de inutilidade, dificuldade de concentração e pensamentos suicidas. Uma das hipóteses relacionadas a essa condição é a diminuição dos níveis de neurotransmissores extracelulares, incluindo, por exemplo, a serotonina. O inibidores seletivos da recaptação da serotonina (ISRS) agem aumentando os níveis desse neurotransmissor na fenda sináptica. O objetivo do trabalho é analisar os efeitos do uso dos inibidores seletivos da recaptação de serotonina no tratamento da depressão. Trata-se de uma revisão narrativa dos últimos 3 anos, do período de 2021 a 2024, utilizando a base de dados da MEDLINE com os descritores: "depressão" "efeito" "inibidores" "recaptação" "serotonina" "tratamento". Evidenciou-se um benefício do uso dos ISRS no tratamento da depressão, reduzindo os sintomas dessa condição. Essa classe de fármaco age promovendo um aumento quantitativo da serotonina na fenda sináptica, elevando as chances de estímulo nos receptores e logo, proporcionando o efeito antidepressivo. Algumas diretrizes preconizam o uso farmacológico de ISRS associado ao tratamento não farmacológico, como prática de atividade física e terapia cognitivo comportamental como tratamento de primeira opção de tratamento. Nessa perspectiva, evidencia-se a importância do uso dessa classe de fármaco para o tratamento da depressão.
Application of 3D-printed individualized porous tantalum buttress in shelf acetabuloplasty for developmental dysplasia of the hip
Authors: Peng Yang , Chen Xin , Xu Juncai , Xiong Ran , Huang Chengjun , Yang Liu , Chen Guangxing
Published: August 2024

Shelf acetabuloplasty is a viable treatment for developmental dysplasia of the hip (DDH), yet autologous bone grafts have faced challenges such as morphological mismatch, imprecise placement, and long-term graft resorption. The rapid advancement of 3D printing technology in orthopedics has enabled the acquisition of digital image correlation method (DICM) data from patient pelvic to bilateral femoral proximal regions through computed tomography (CT) scans. These data are then utilized by software to create 3D models and design individualized metal implants. Using tantalum-based type I (TA1) spherical powder as the raw material, a porous tantalum buttress with a pore size of 600 microns and a porosity of 75% was fabricated employing the selective electron beam melting (SEBM) technology. Our Center has applied this 3D-printed individualized porous tantalum buttress in shelf acetabuloplasty for 21 DDH patients (25 hips), including 6 males and 15 females, with a mean age of 21.38 ± 7.39 years. The follow-up period ranged from 12 to 47 months, averaging 22.64 ± 10.86 months. At the final follow-up, patient-reported outcomes (PROs) were used to assess the patient’s subjective feelings. Significant improvements were observed in the Non-Arthritic Hip Score (NAHS), modified Harris Hip Score (mHHS), Hip Outcome Score-Sports Subscale (HOS-SSS), International Hip Outcome Tool-12 (iHOT-12), and Visual Analog Scale (VAS) compared with preoperative levels (p < 0.01). Radiographic assessments indicated that the postoperative lateral centeredge (LCE) angle, Tonnis angle, acetabular angle (Sharp’s angle), and femoral head coverage all trended towards normal, with statistically significant differences (p < 0.01). There was no implant displacement or bone resorption in any case, and no progression in Tonnis grading for hip osteoarthritis (OA) was noted postoperatively, with an 84% patient satisfaction rate. The early follow-up results of 3D-printed individualized porous tantalum buttress in shelf acetabuloplasty are satisfactory, indicating a reliable application prospect for the treatment of DDH patients.
Electrospun polylactic acid-glycolic acid composite hydrogel scaffold loaded with 3D extracellular vesicles for nasal septal cartilage defect repair
Authors: Yang Jie , Hu Haolei , Guo Qiang , Chen Xiaolei , Li Shuo , Yin Gang , Yue Wei , Zhang Yi , Liu Boxun , Chen Jianwei , Xu Tao , Li Yi
Published: August 2024

The nasal septum plays an important role in the growth and support of the human nose, and defects can cause nasal deformities. Extracellular vesicles (EVs) have demonstrated great potential in tissue repair. Stem cell EVs are widely used in the repair of articular cartilage defects, but their use for nasal septal cartilage defects has not been reported. Due to the low yield and loss of EVs during in situ injection, improved preparation methods and better carriers are needed for the effective sustained release of EVs in wounds. In this study, swelling and degradation experiments were initially conducted on the scaffold, along with mechanical performance testing, including observation of the scaffold morphology using scanning electron microscopy (SEM). Subsequently, in vitro cell experiments were conducted to evaluate the ability of 3D EVs to promote chondrocyte proliferation, migration, and extracellular matrix formation. Finally, the EV-laden gelatin methacrylic acid-polylactic acid-glycolic acid (Gel-PLGA) composite scaffold was implanted into the nasal septum defect site of rabbits in vivo to observe its repair effect on the defect. In vitro experiments demonstrated that the biological scaffold exhibited good biocompatibility and could effectively promote the proliferation and migration of chondrocytes. In vivo, the EV-laden composite biological scaffold was implanted into the nasal septum defect of rabbits, and the tissues were tested at 6 and 12 weeks after surgery. The results indicate that the composite scaffolds effectively facilitated the repair of defect sites. Taken together, 3D EVs facilitate tissue repair and healing, offering a novel approach to treating nasal septal defects.
Green Credits: A Bibliometric Analysis of Publications in the Web of Science
Authors: Özgün Fergül
Published: August 2024

Sustainable development goals emphasize disseminating projects that do not pollute the environment. Green credit is one of the primary tools used to support and finance environmentally friendly projects. Thus, green credits appear to be a current research area. This research aims to conduct a bibliometric analysis of studies on green credits. To achieve this goal, we reviewed 2,630 studies published in the Web of Science database between 1980 and 2024. We presented the changes in the number of studies and citations over time, along with details about the most cited studies. In the literature review section, in particular, studies published recently were examined. Then, we categorize the studies based on document and index type, written language, countries, subjects, and citation categories. Our main results are: The most intense years for studies on green credits are 2022 and 2023. 98% of the studies were published in English, with over 80% being article-based. China leads the list of countries to conducting the most studies. The first three categories with the most studies are environmental sciences, green sustainable science technology, and economics. As the number of studies increased over time, citations also increased.
Health Promotion Analysis on Gastritis: Students' Knowledge and Attitudes Towards Students' Health
Authors: Tulyani Khalifah
Published: August 2024

Purpose of the study: The purpose of this study was to evaluate health promotion regarding gastritis on improving health knowledge of high school students. Tomeasure the effectiveness of social media as a means of health education, as well as identify factors that influence the success of health promotion in improving students' understanding of gastritis.
Methodology: This study uses a qualitative approach to explore the analysis of health promotion regarding gastritis towards health knowledge of high school students. The population is 20 students in junior high school 10 Bengkulu who had access to social media. Data collection techniques used in-depth interviews and focus group discussions. Data obtained from interviews were analyzed using thematic analysis methods.
Main Findings: This research shows that health promotion about gastritis through social media is effective in increasing secondary school students' knowledge, attitudes and health behavior. Even though there arin access and understanding of information, the use of digital platforms has proven to be able to reach and engage students in a more dynamic and interactive way.
Novelty/Originality of this study: The novelty of this study lies in the use of social media as the main tool in health promotion regarding gastritis. This approach offers a new and more effective way to reach high school students, compared to traditional methods such as lectures or distributing brochures. Social media has the potential to deliver health information in more engaging and interactive way.
Analysis of Community Health Center Performance on Tuberculosis Control Programs
Authors: Essenzi Desma Sekar
Published: August 2024

Purpose of the study: To explore and analyze the implementation of the Tuberculosis control program using the DOTS strategy at the Satelit Community Health Center. This research aims to identify factors that support and hinder the implementation of the program, evaluate the effectiveness of approaches that integrate Islamic values ​​in health education.
Methodology: This research uses a qualitative method with a case study design. The population in this study were all individuals involved in the TB control program at the Satellite Health Center. The data collection technique in this research uses in-depth interviews with guided questions that have been prepared in advance. Data obtained from interviews were then analyzed using thematic analysis method.
Main Findings: This research shows that the implementation of the Tuberculosis control program at the Satelit Community Health Center has gone well even though it still faces various challenges. The success of the program is greatly influenced by political commitment, the performance of the Medication Monitor (PMO), as well as adequate facilities and training support. The integration of Islamic values in health education has proven effective in increasing patient compliance and community participation.
Novelty/Originality of this study: The novelty of this research lies in the holistic approach in evaluating the performance of community health centers in managing TB, which includes the use of information technology to improve data recording and reporting, intensive training for medical staff in TB case management, as well as improving the infrastructure of community health centers to support more efficient services.
Exploring Students' Knowledge about Hand Washing with Soap Through Video Media at Middle School
Authors: Pustika Dinda Dwi
Published: August 2024

Purpose of the study: This research aims to evaluate the effectiveness of using video media in increasing students' knowledge and attitudes about the importance of washing hands with soap at Public Middle School 31 North Bengkulu
Methodology: This research uses quantitative methods with a pre-experimental One Group Pretest-Posttest Design. The research population was class III students at Public Middle School 31 North Bengkulu, with a sample of 35 students selected using a purposive sampling technique. Data analysis was carried out using the Wilcoxon test to test the difference between pretest and posttest results.
Main Findings: This study concludes that the use of video media as a health promotion tool significantly increases the knowledge and attitudes of students at Public Middle School 31 North Bengkulu towards the importance of washing hands with soap. Video media is proven to be more effective than conventional methods in attracting attention and increasing student participation during the learning process
Novelty/Originality of this study: This research is very urgent considering the high rate of transmission of infectious diseases among adolescents which can have a significant impact on their health and school attendance. Infectious diseases such as flu, diarrhea and respiratory infections often spread quickly in the school environment, causing high levels of absenteeism and reducing learning productivity.
Exploration of the Influence: Self Action, Self Efficacy on Student Creativity in General Biology
Authors: Fadhilah Fadhilah
Published: August 2024

Purpose of the study: This study aims to explore the relationship between self-action and self-efficacy with students' creativity in Biology practicum activities. In the context of higher education, understanding the factors that influence creativity, such as self-action and self-efficacy, is very important for designing. Methodology: This is a quantitative study with an ex post facto research method. This study involves three variables, two independent variables and one dependent variable. The sample variables were taken using the Simple Random Sampling technique, so that the researcher obtained sample of 74 students. This study used questionnaire instrument. The data analysis techniques used were descriptive statistics and inferential statistics. Main Findings: The results of this study indicate that for self-action and self-efficacy, the average score is in the moderate category. While for student creativity, the average score is also in the moderate category. The results of inferential statistical analysis with the F test indicate a significant influence between self-action and self-efficacy on student creativity in General Biology practicum activities in the Biology Education Study Program, Fatmawati Sukarno State Islamic University, Bengkulu. Novelty/Originality of this study: This research pays attention to psychological aspects, such as how individuals act towards themselves (Self Action) and individual beliefs in their abilities (Self Efficacy), which may have a significant influence on students' ability to produce creativity when participate in General Biology practicum activities. Focusing on the context of practicum activities can illustrate the influence of these variables in real.
Heat and Mass Transfer Analysis of Chemically Reactive Powell-Eyring Nanofluid Flow Over a Wedge: A Numerical Approach
Authors: Agarwal Pooja , Jain Reema , Loganathan K. , Udhayakumar R.
Published: August 2024

The present study describes the effects of different parameters on heat and mass transfer phenomena in fluid flow across a wedge. A non-Newtonian chemically reactive Powell-Eyring nanofluid model is considered for analysis. The governing equations for the boundary layer regime are derived by applying the principles of mass, momentum, and energy conservation. Using similarity transformation, the partial differential equations (PDEs), with boundary conditions are converted into ordinary differential equations (ODEs). With prescribed boundary conditions in the free stream and at the wall, these equations are simplified into an ordinary differential equations system. This simplification is attained using appropriate scaling of similarity transformations which produce a number of important dimensionless control parameters. The computational solution to the nonlinear coupled boundary value problem is obtained using the bvp4c numerical tool in MATLAB. The effects of the various physical parameters on the energy, velocity and mass profiles are investigated through graphs and tables. Also, Nusselt number, skin friction coefficient, and Sherwood number are explored. Validation with previous studies is included.
IL-6 signaling pathway differentiation for endometriosis and inflammatory diseases
Authors: Castle Ryan D.
Published: August 2024

Interleukin-6 (IL-6) plays a critical role in the pathogenesis of various chronic inflammatory diseases, tracked across numerous fields of research. Despite this, a crucial aspect often overlooked in studies is the differentiation between IL-6 classic-signaling and trans-signaling, leading to potential confounding of their findings; less than half of selected IL-6 studies included differentiation. This review delves into the distinction between IL-6 classic- and trans-signaling and their role in chronic inflammatory diseases and endometriosis. The unique pro-inflammatory nature of IL-6 trans-signaling, contrasted with the anti-inflammatory character of IL-6 classic-signaling, presents significant implications for research methodology, particularly in studies investigating anti-inflammatory interventions or interleukin inhibitors. Diagnostic failure to account for these distinct pathways may inadvertently misrepresent beneficial immune responses or the efficacy of interventions, posing significant challenges in predicting health outcomes. Interventions that do not differentiate these pathways could face reduced efficacy or safety. This review proposes adjustments to research methodologies and stresses the importance of careful interpretation of inflammatory markers in IL-6-related research. Examples of differentiation issues are discussed across the topics of endometriosis and multiple inflammatory diseases. By addressing this methodological issue, researchers could potentially improve patient outcomes, enhance the efficacy of interventions, and contribute to public health advancements.
Pengaruh Budaya Organisasi, Intregritas Dan Loyalitas Terhadap Kinerja Karyawan Bank Bri Unit Tubei Kanca Curup
Authors: Novella Tressa Rud , Fauzan Markoni,
Published: August 2024

To find out how big the influence of Organizational Culture is on Employee Performance, the Influence of Integrity, the Influence of Loyalty at Bank BRI Tubei Kanca Curup Unit. This research uses data collection techniques by distributing questionnaires, the sampling technique is using saturated or proballty sampling techniques. This research uses an approach quantitative which is explanatory in nature. There is an influence of organizational culture (X1) on employee performance (Y) BRI Bank Store Tubei Kanca Curup Unit with a value of tsig < α (0.001 ttable (2.571> 1.68107) with Thus, Ho is rejected and Ha is accepted. There is an influence of integrity (X2) on employee performance (Y) at the BRI Bank Store, Tubei Kanca Curup Unit with a value of tsig < α (0.004 ttable (2.571> 1.68107) Thus Ho is rejected and Ha is accepted. There is an influence of loyalty (X3) on employee performance (Y) of the BRI Bank Shop Tubei Kanca Curup Unit with a value of tsig < α (0.003 ttable (2.571> 11.68107) thus Ho is rejected and Ha accepted.

Keywords : Influence of Organizational Culture, Integrity and Loyalty
Analisa Faktor-Faktor Yang Mempengaruhi Pendapatan Pedagang Ritel Dikabupaten Karanganyar
Authors: Rowiyani Rowiyani , Pamastutiningtyas Terrensia Sekar , Muslikhun Alfin , Mukhlidin Mukhlidin
Published: August 2024

This research aims to analyze the factors that influence the income of retail traders in Karanganyar Regency, namely analysis of business capital, marketing strategies, and entrepreneurial characteristics on the income of retail traders in Karanganyar Regency.. This research uses a quantitative approach with primary data collected through questionnaires. The research sample was selected using a purposive sampling technique, which includes various types of retail businesses in Karanganyar Regency. The data analysis methods used include instrument testing, classical assumption testing, and hypothesis testing using SPSS for Windows. The research results show that business capital, marketing strategies, and entrepreneurial characteristics have a significant positive effect on retail traders' income. The Adjusted R² value of 0.872 shows that the three independent variables are able to explain 87.2% of the variation in retail traders' income, while 12.8% is explained by other factors. Validity and reliability tests show that the instruments used meet the validity and reliability requirements. The classical assumption test also shows that the data used meets the assumptions of normality, there is no multicollinearity, heteroscedasticity and autocorrelation. Based on the results of the analysis, it is recommended that retail traders increase creativity and innovation in entrepreneurial characteristics, as well as optimize business capital and marketing strategies, especially in the use of technology digital. Future research is recommended to take a larger sample and add other independent variables that might influence retail traders' income to obtain more comprehensive results.
Keywords: Business Capital, Marketing Strategy, Entrepreneurial Characteristics, Retailer Income
Pengaruh Biaya Produksi, Biaya Operasional Dan Volume Penjualan Kamar Terhadap Laba Bersih Pada Grand Rocky Hotel Bukittinggi
Authors: Nengsih Yeni Rafika , Sari Desi Ratna
Published: August 2024

Penelitian ini bertujuan untuk menganalisis Pengaruh Biaya Produksi, Biaya Operasional, Dan Volume Penjualan Kamar Terhadap Laba Bersih pada Grand Rocky Hotel Bukittinggi baik secara parsial maupun secara Bersama-sama. Data yang digunakan adalah data sekunder yang di peroleh secara tidak langsung yang dicatat oleh perusahaan. Populasi dalam penelitian ini adalah data laporan laba rugi, Laporan biaya produksi dan laporan penjualan kamar pada Grand Rocky Hotel Bukittinggi periode 2018- 2022. Penelitian ini menggunakan analisis regresi linear berganda dengan menggunakan SPSS versi 24. Hasil pengujian hipotesis secara parsial membuktikan bahwa biaya produksi berpengaruh signifikan terhadap laba bersih, biaya operasional berpengaruh signifikan terhadap laba bersih dan volume penjualan kamar berpengaruh signifikan terhadap laba bersih. Secara Bersama-sama biaya produksi, biaya operasional dan volume penjualan kamar berpengaruh signifikan terhadap laba bersih dengan nilai koefisien determinasi sebesar 77,1% sedangkan sisanya 22,9% di paparkan oleh factor-faktor lain yang belum diteliti.

Kata Kunci: Biaya Produksi, Biaya Operasional, Volume Penjualan Kamar, Laba Bersih
Pengaruh Komitmen Pemerintah Daerah , Kompetensi Dan Teamwork Terhadap Efektifitas Penerapan Sistem Akuntabilitas Kinerja Instansi Pemerintah (Sakip) Di Kota Payakumbuh
Authors: Irnaldi Irnaldi , Amelia Dona
Published: August 2024

Penelitian ini betujuan untuk menganalisis dan menguji pengaruh, komitmen pemerintah daerah, kompetensi dan kerjasama tim terhadap efektifitas penerapan sistem akuntabilitas kineja instansi pemerintah (SAKIP) di Kota Payakumbuh, Jenis penelitian ini adalah penelitian kausal komparatif. Populasi dalam penelitian ini adalah ASN yang mengelola Sistem Akuntabilitas Kineja Instansi Pemerintah (SAKIP) pada 31 perangkat daerah di pemerintah Kota Payakumbuh. Metode pengambilan sampel menggunakan metode sensus, dimana seluruh anggota dijadikan sampel penelitian. Penelitian ini menggunakan data primer yang diperoleh melalui quisioner yang disampaikan secara langsung kepada Sekretaris OPD dan Kepala Sub Bagian Program dan Keuangan dari setiap perangkat daerah, dari 62 quiseioner yang disebar seluruhnya mengembalikan quisioner tersebut. Data diolah dengan menggunakan analisis Structural Equation Modeling (SEM) dan pengujian SEM ini menggunakan aplikasi SmartPLS. Hasil penelitian uji hipotesis menunjukan bahwa, komitmen pemerintah daerah berpengaruh positif dan tidak signifikan terhadap efektifitas penerapan Sistem Akuntabilitas Kinerja Instansi Pemerintah (SAKIP), kompetensi berpengaruh negatif dan signifikan terhadap efektifitas penerapan Sistem Akuntabilitas Kinerja Instansi Pemerintah (SAKIP) dan teamwork berpengaruh positif dan signifikan terhadap efektifitas penerapan Sistem Akuntabilitas Kinerja Instansi Pemerintah (SAKIP) Pemerintah Kota Payakumbuh
Kata Kunci: Komitmen Pemerintah Daerah, Kompetensi, Teamwork, Efektifitas Penerapan SAKIP
Penilaian Untuk Akuisisi Rumah Sakit: Evaluasi Kelayakan Finansial Di Sektor Kesehatan
Authors: Yogantara Satya Elang , Faturohman Taufik
Published: August 2024

PT SMI berencana mengakuisisi sebuah rumah sakit di Bandar Lampung sebagai bagian dari ekspansi strategis di sektor kesehatan. Akuisisi ini bertujuan untuk mendukung misi PT SMI dalam menyediakan layanan kesehatan berkualitas tinggi dan meningkatkan infrastruktur kesehatan regional. Penelitian ini mengevaluasi kelayakan finansial dari rencana akuisisi ini secara menyeluruh, memberikan wawasan penting bagi pengambil keputusan untuk menilai kelayakan investasi. Analisis keuangan dilakukan menggunakan metode Diskonto Arus Kas (DCF), dengan tingkat diskonto sebesar 12% untuk menghitung Nilai Kini Bersih (/NPV) dan Tingkat Pengembalian Internal (IRR). Investasi awal yang dibutuhkan untuk akuisisi ini adalah Rp 55.680.178.000. Hasil analisis menunjukkan NPV sebesar Rp 7.300.351 dan IRR sebesar 14.40%. Hasil ini mengindikasikan bahwa akuisisi ini layak secara finansial berdasarkan asumsi yang digunakan. NPV yang positif menunjukkan bahwa arus kas yang diharapkan cukup untuk menutupi investasi awal dan biaya terkait, sementara IRR yang lebih tinggi dari tingkat diskonto menunjukkan bahwa tingkat pengembalian investasi memenuhi syarat minimum. Analisis sensitivitas mengidentifikasi dua belas faktor kritis yang mempengaruhi valuasi, termasuk Tingkat Hunian Tempat Tidur (BOR), Lama Tinggal (LOS), volume pasien, kenaikan tarif, biaya akuisisi, belanja modal, biaya pendapatan, biaya operasional, dan Biaya Modal Rata-Rata Tertimbang (WACC). Berdasarkan temuan ini, beberapa rekomendasi diajukan untuk meningkatkan valuasi rumah sakit dan memastikan keberhasilan jangka panjang. Rekomendasi ini mencakup optimalisasi efisiensi operasional, peningkatan manajemen keuangan, perluasan dan diversifikasi layanan, penguatan posisi pasar, pembudayaan perbaikan berkelanjutan, penerapan praktik berkelanjutan, pemanfaatan kemitraan strategis, fokus pada perawatan yang berpusat pada pasien, dan pemantauan perubahan regulasi. Dengan mengatasi faktor-faktor ini dan menerapkan strategi yang direkomendasikan, PT SMI dapat mengoptimalkan hasil finansial dan strategis dari akuisisi rumah sakit ini, memastikan keberlanjutan dan kesuksesan di industri kesehatan yang kompetitif.
Keywords: Kelayakan Finansial, Rumah Sakit, Valuasi Akuisisi, Aliran Kas Terdiskonto, Investasi Kesehatan
Penilaian Untuk Akuisisi Sekolah Dasar: Evaluasi Kelayakan Finansial Di Sektor Pendidikan
Authors: Syauqi Shidqi , Faturohman Taufik
Published: August 2024

ABSTRAK
YAB Foundation sedang mempertimbangkan akuisisi sebuah sekolah dasar swasta di Bandung sebagai bagian dari ekspansi strategis di sektor pendidikan. Akuisisi ini bertujuan untuk mendukung misi YAB dalam menyediakan pendidikan berkualitas tinggi dan mendukung pengembangan pendidikan regional. Tesis ini secara komprehensif mengevaluasi kelayakan finansial dari usulan akuisisi ini, memberikan wawasan penting bagi pengambil keputusan untuk menilai kelayakan investasi. Analisis keuangan menggunakan metode aliran kas terdiskonto (Discounted Cash Flow), dengan memanfaatkan tingkat diskonto sebesar 11,33% untuk menghitung nilai saat ini (Net Present Value) dan tingkat pengembalian internal (Internal Rate of Return). Investasi awal yang diperlukan untuk akuisisi ini adalah sebesar Rp 22.500.000.000. Hasil analisis keuangan menunjukkan nilai saat ini negatif sebesar Rp -5.059.749.78 dan tingkat pengembalian internal sebesar 6,88%. Temuan ini menunjukkan bahwa akuisisi mungkin tidak layak secara finansial berdasarkan asumsi saat ini. Nilai saat ini yang negatif mengindikasikan bahwa arus kas yang diharapkan tidak cukup untuk menutupi investasi awal dan biaya terkait. Tingkat pengembalian internal yang lebih rendah dari tingkat diskonto menunjukkan bahwa tingkat pengembalian investasi tidak memenuhi persyaratan minimum. Oleh karena itu, YAB Foundation perlu mempertimbangkan negosiasi ulang harga akuisisi dan penerapan langkah-langkah efisiensi biaya untuk meningkatkan kelayakan finansial. Peningkatan jumlah siswa dan optimalisasi tarif biaya sekolah juga dapat membantu meningkatkan pendapatan dan mengurangi risiko keuangan. Analisis ini memberikan dasar yang kuat bagi YAB Foundation dalam membuat keputusan strategis yang tepat terkait investasi ini.
Keywords: Kelayakan Finansial, Sekolah Dasar, Valuasi Akuisisi, Aliran Kas Terdiskonto, Investasi Pendidikan
Peran eWOM dan Loyalitas Sikap dalam Memediasi Publisitas Negatif Terhadap Loyalitas Perilaku Konsumen Honda
Authors: Usulu Reyhan Qatrunada , Maesaroh Syti Sarah , Prehanto Adi
Published: August 2024

Berita negatif yang mencuat pada bulan Agustus 2023 telah mencoreng reputasi merek Honda. Berita ini bermula dari banyaknya muncul unggahan yang memperlihatkan sepeda motor Honda mengalami patah rangka. Berita ini menyebabkan Honda menerima banyak kritikan di media daring yang menyatakan kekecewaan dan keengganan untuk menggunakan sepeda motor Honda lagi. Tujuan dari penelitian ini adalah untuk menganalisis pengaruh publisitas negatif melalui dua perspektif loyalitas, yaitu sikap dan perilaku. Penelitian ini juga menganalisis pengaruh eWOM dalam penyebaran berita negatif pada loyalitas. Penelitian ini menggunakan pendekatan kauntitatif dengan jumlah sampel sebanyak 140 responden. Metode analisis pada penelitian ini menggunakan analisis jalur. Hasil dari penelitian ini menunjukkan bahwa publisitas negatif tidak berpengaruh terhadap loyalitas perilaku, namun efektif terhadap loyalitas sikap dan eWOM. Loyalitas perilaku dapat dipengaruhi oleh loyalitas sikap, namun tidak dengan eWOM. Sementara itu, mediasi loyalitas sikap sukses pada hubungan publisitas negatif terhadap loyalitas perilaku, namun tidak dengan mediasi eWOM.

Keywords:
Publisitas Negatif, Loyalitas Sikap, Loyalitas Perilaku, eWOM, Loyalitas Konsumen
Analysis Of Financial Performance Of Consumer Goods Industry Sector Companies Listed On The Idx In 2020-2022
Authors: Sari Hanna Ratna , Kurniawati Susilaningtyas Budiana
Published: August 2024

This research aims to determine the effect of profitability, liquidity, solvability and activity ratios on financial performance of companies in the consumer goods industry sector listed on the IDX in 2020-2022. The method chosen is a quantitative research method because it deals with numbers. Samples taken with purposive sampling technique, this technique is obtained with certain characteristics. The sample obtained was 60 companies. Descriptive statistical analysis and multiple regression analysis used in the process of checking this data. The research results state that partially profitability, liquidity, solvability and activity ratios influence financial performance. Simultaneously profitability ratios, liquidity ratios, solvitability ratios and activity ratios influence financial performance.
Keywords: Profitability; Likuidity; Solvability; Activity; Financial Performance
CALCULATION OF STRENGTH OF FLEXIBLE CONCRETE BEAMS WITH BASALT REINFORCEMENT ON VERTICAL SECTIONS
Authors:   Doctoral student at FarPI, Uzbekistan, Abduxalimjonovna Mirzaaxmedova Ugiloy , Juraevich Razzakov Sobirjon ,   Professor at NamECI, Uzbekistan
Published: August 2024

This article presents the methods of calculating the fracture resistance of bending concrete beams with basalt reinforcement on vertical (normal) sections, the conducted research and the analysis of comparing the experimental results with the calculated results.
THE CONCEPT OF EQUAL PARENTING: A SOLID FOUNDATION FOR FAMILY WELL-BEING (WORLD PRACTICE)
Authors:   Jizzakh State Pedagogical University, Uzbekistan, Axmedshina Fanya
Published: August 2024

The concept of equal parenting is becoming increasingly important in modern society. This model of parenthood promotes the emotional well-being of children, improves the psycho-emotional state of parents and creates a harmonious family atmosphere. The equal distribution of responsibilities helps to reduce stress, supports the professional and personal fulfillment of parents, and also contributes to the destruction of gender stereotypes. As a result, equal parenting creates a solid foundation for family well-being and sustainability, positively affecting all family members and society as a whole.
THE CONTRIBUTION OF GERMAN SCIENTISTS TO THE SCIENTIFIC STUDY OF RUSSIAN TURKESTAN AT THE END OF THE 19TH AND BEGINNING OF THE 20TH CENTURIES
Authors:   Doctoral student (PhD) of Samarkand state university named after Sharof Rashidov, Uzbekistan, Zulkhumor Khasanova
Published: August 2024

In the article the issue of contribution of German scientists to scientific research of Turkistan of end XIX-beginning of XX centuries is considered. They were guided in their activity by scientific investigation of history and social-economical life of the country. Their scientific works are historical sources in studying of the history of Turkistan of the period of colonization.
THE TREATMENT OF THE ISSUE OF "RU'YATULLAH" IN SAFFOR BUKHARI'S "TALKHISUL ADILLAH"
Authors:   Independent researcher, Imam Bukhari International Research Center, Uzbekistan, Shukurovich Toxir Evadullayev
Published: August 2024

Saffor Bukhari is considered one of the representatives of the creed established by Imam Maturidi in the 5th-6th centuries AH. He is recognized as a scholar of the third period who made a significant contribution to the development of Maturidi teachings. His work titled "Talkhisul Adillah li Qawadi Tawhid" pertains to the science of Kalam and gained great fame during his time. In this work, the author discusses the issue of "Ru'yatullah" (the vision of God) in a manner specific to Maturidi Hanafi scholars. He refutes the incorrect and baseless beliefs of various misguided sects such as the Mu'tazila, Kharijites, Najjariyya, Zaydi, and Jahmi regarding this issue by relying on the Qur'an and Hadith and providing rational and textual evidence against them.
CHARACTERISTICS OF IMPLEMENTATION OF INCLUSIVE EDUCATION IN UZBEKISTAN AT THE PRESENT STAGE
Authors:   Professor, PhD, Tashkent State Pedagogy named after Nizomi university, Tashkent, Uzbekistan, Nurkeldieva Dilbar
Published: August 2024

The article is devoted to the implementation of the inclusive education system in the Republic of Uzbekistan. Regarding this, foreign and local legal documents, statistical data on the operation of inclusive classes in general education schools are presented, and prospects for the successful introduction of inclusive education are reflected in the future.
El fetiche de un documento legal: Migraciones, leyes y fronteras
Authors:   Universidad La Salle Pachuca, Liedo Lavaniegos Joaquín , Salah Rasha ,   Universidad La Salle Pachuca
Published: August 2024

El presente texto es una colaboración en pareja que busca dar cuenta del importante rol que juega la documentación y la legalidad dentro de la vida de las personas migrantes, no como garantías o una suerte de “piso parejo”, sino como condicionales restrictivas que permean el tránsito y las opciones que se tienen durante la migración. Para abordar lo anterior, nos insertamos en dos ramas antropológicas, una que gira en torno a la antropología de las migraciones, y una segunda que interroga al marco legal a partir de la antropología jurídica.