bluuebunny/crossref_metadata_2025 huggingface dataset:
Electrochemical Preparation of Nano-Sized Silicon as a Lithium-Ion Battery Anode Material
Authors: Shen Lingling , Wang Dexi , Ali Kamali , Li Ming , Shi Zhongning
Published: November 2021

Highly pure silicon is an important component in photovoltaic applications and has potential in battery technology. In this study, the electrochemical behavior of Si (IV) was discussed in a NaF−LiF−Na2SiO3−SiO2 electrolyte at 750 °C, and lithium-ion battery performance with electrodeposited silicon powder as anode material were investigated. The cyclic voltammograms illustrated that the reduction of Si(IV) on an Ag electrode followed an irreversible two-step, two-electron process: Si(IV) → Si(II) and Si(II) → Si(0). Both reduction steps involved diffusion control, and the diffusion coefficients were 1.18 and 1.22 × 10−6 cm2 s−1, respectively. Nanoscale spherical silicon was deposited between potentials of −1.0 to −1.6 V (vs Pt) with support of X-ray diffraction patterns, Raman spectra, and scanning electron microscopy analysis. Combining the fabricated silicon with carbon, a Si@C composite anode material for lithium-ion batteries was prepared, and its specific capacity reached 1260 mA·h g−1. Notably, a capacity of 200 mA·h g−1 was maintained over 100 cycles.
A Model for Investigating Sources of Li-Ion Battery Electrode Heterogeneity: Part II. Active Material Size, Shape, Orientation, and Stiffness
Authors: Nikpour M. , Mazzeo B. A. , Wheeler D. R.
Published: November 2021

This work is the extension of our previous paper [Nikpour et al., J. Electrochem. Soc.
168, 060547, (2021)] which introduced the multi-phase smoothed particle (MPSP) model. This model was used to simulate the evolution of the microstructure during the drying and calendering manufacturing processes of four different electrodes. The MPSP model uses particle properties to predict overall film properties such as conductivities and elastic moduli and is validated by multiple experiments. In this work, the model is used to investigate the effects of active material particle size, shape, orientation, and stiffness on graphitic anodes. The model predicts that smaller active particles produce higher calendered film density, electronic conductivity, MacMullin number, and Young’s modulus, as compared to larger active particles. Rod-shaped active materials have greater ionic transport and lower electronic transport compared to the disk and sphere shapes, which have similar transport properties. During calendering, disk-shaped particles tend to be oriented horizontally, which decreases through-plane ionic transport. Increasing the stiffness of the active material increases film porosity and composite Young’s modulus, while lowering electronic transport and increasing ionic transport.
Ultra-Stable Lithium-Sulfur Batteries Using Nickel Phosphide@Carbon Fabric Interlayer
Authors: Yang Kyeong Min , Kim Soochan , Yang Kaiwei , choi Sungsik , Cho Misuk , Lee Youngkwan
Published: November 2021

Lithium-sulfur batteries (LSB) are highly promising candidates for next generation energy storage devices due to their high theoretical capacity and the low cost of sulfur. However, dissolution of lithium polysulfides (LPS) into electrolyte causes undesirable effects, resulting in loss of active materials, low Coulombic efficiency, and fast capacity fading. To address these issues, designed interlayers are inserted between a separator and S cathode to evaluate the effect of blocking of long chain LPS and catalytic conversion of LPS to Li2S2/Li2S on battery performance. In order to amplify the effect of interlayer, the Ni2P nanoparticles are electrochemically deposited on carbon fabric (CF) which exhibit excellent adsorption and conversion effect of LPS. A cell fabricated with the Ni2P@CF interlayer allows remarkable improvement in the capacity decay of 0.04% per cycle at 1C for 1000 cycles and outstanding high rate capability. The cell delivered a capacity retention of 64% employing a current density of 8 C.
The Role of Fecal Fusobacterium nucleatum and pks+ Escherichia coli as Early Diagnostic Markers of Colorectal Cancer
Authors: Liu Kaixi , Yang Xinran , Zeng Mi , Yuan Yumeng , Sun Jianhong , He Ping , Sun Jiayu , Xie Qingdong , Chang Xiaolan , Zhang Suwei , Chen Xiang , Cai Leshan , Xie Yanxuan , Jiao Xiaoyang
Published: November 2021

Background. Accurate analysis of intestinal microbiota will facilitate establishment of an evaluating system for assessing colorectal cancer (CRC) risk and prognosis. This study evaluates the potential role of Fusobacterium nucleatum (F. nucleatum) and Escherichia coli with a pks gene (pks+ E. coli) in early CRC diagnosis. Methods. We recruited 139 patients, including CRC (

n
=
60

), colorectal adenomatous polyposis (CAP) (

n
=
37

), and healthy individuals (

n
=
42

) based on their colonoscopy examinations. We collected stool and serum samples from the participants and measured the relative abundance of F. nucleatum and pks+ E. coli in fecal samples by quantitative PCR. Receiver operating characteristic curve (ROC) analyses were used to analyze the diagnostic value of single or combined biomarkers. Results. Fecal F. nucleatum and pks+ E. coli levels were higher in the CRC group in either the CAP group or healthy controls (

P
=
0.02

; 0.01). There was no statistical difference in the distribution of F. nucleatum and pks+ E. coli in patients with different tumor sites (

P
>
0.05

). The combination of F. nucleatum+pks+ E. coli+CEA+CA19-9+FOBT was chosen as the optimal panel in differentiating both CRC and CAP from the controls. The combination of F. nucleatum, pks+ E. coli, and FOBT improved diagnostic efficiency. However, there was difficulty in differentiating CRC from CAP. Conclusion. Our results suggested that combining bacterial markers with conventional tumor markers improves the diagnostic efficiency for noninvasive diagnosis of CRC.
A Review of P4 Programmable Data Planes for Network Security
Authors: Gao Ya , Wang Zhenling
Published: November 2021

Network attacks show a trend of increased attack intensity, enhanced diversity, and more concealed attack methods, which put forward higher requirements for the performance of network security equipment. Unlike the SDN (software defined network) switch with a fixed-function data plane, switches with programmable data planes can help users realize more network protocols. Programming Protocol-independent Packet Processors (P4) is proposed to define the operations of the data plane and to implement user’s applications, e.g., data center networks, security, or 5G. This paper provides a review of research papers on solving network security problems with P4-based programmable data plane. The work can be organized into two parts. In the first part, the programming language P4, P4 program, architectures, P4 compilers, P4 Runtime, and P4 target are introduced according to the workflow model. The advantages of P4-based programmable switching in solving network security are analyzed. In the second part, the existing network security research papers are divided into four parts according to the perspectives of passive defense, active defense, and combination of multiple technologies. The schemes in each category are compared, and the core ideas and limitations are clarified. In addition, a detailed comparison is made for the research on the performance of P4 targets. Finally, trends and challenges related to the P4-based programmable data plane are discussed.
Highly Sensitive Detection of Trace Tetracycline in Water Using a Metal-Organic Framework-Enabled Sensor
Authors: Chen Jiezeng , Shu Hongying , Niu Pingping , Chen Pinghua , Jiang Hualin
Published: November 2021

Due to the abuse application of antibiotics in the recent decades, a high level of antibiotics has been let out and remains in our environment. Electrochemical sensing is a useful method to sensitively detect antibiotics, and the key factor for a successful electrochemical sensor is the active electrode materials. In this study, a sensitive electrochemical sensing platform based on a metal-organic framework (MOF) of MIL-53 (Fe) was facilely fabricated. It shows highly selective and sensitive detection performance for trace tetracycline. Differential pulse voltammetry (DPV) was applied to analyze the detection of tetracycline. The linear range of tetracycline detection was 0.0643  μmol/L-1.53  μmol/L, and the limit of detection (LOD) is 0.0260  μmol/L. Furthermore, the MOF-enabled sensor can be effectively used in actual water bodies. The results indicate that the electrochemical sensor is a high potential sensing platform for tetracycline.
Stress Distribution and Mechanical Behaviour of Rock Mass Containing Two Openings Underground: Analytical and Numerical Studies
Authors: Tan Lihai , Wang Gaofeng , Ren Ting , Dou Linming , Yang Xiaohan , Song Shikang
Published: November 2021

In this study, stress solution for rock mass containing two rectangular openings was calculated based on the Schwarz alternating method to investigate the stress distribution in rock mass around openings with different layouts. In addition, large-scale numerical models were further established for the two-opening system by means of the PFC-FLAC coupling method, in which the stress evolution, failure patterns, and acoustic emission (AE) events were presented. With the combination of analytical and numerical solutions, the interaction mechanism between two openings under different layouts was discussed from the perspective of stress and failure. The result shows that the confining stress within a certain range contributes to relieving tensile stress concentration around openings. The stress condition within the connecting area and coalescence pattern between two adjacent openings is dominated by their layout. Compared with small-size rock specimens in laboratory tests, the failure patterns around openings show a better agreement with the stress concentration characteristics determined by analytical stress solutions.
CIPC: A Change Impact Propagation Computing Based Technique for Microservice Regression Testing Prioritization
Authors: Chen Lizhe , Yu Xiang , Wu Ji , Yang Haiyan
Published: November 2021

Regression testing is the optimal technique that can be used in each iteration of microservice systems. However, regression testing prioritization is the only main method that gives better results. These techniques directly involve the processes of artifacts, data acquisition, analysis, and maintenance. The microservice systems have input data, which are difficult to obtain and control, while such processes are of high costs with impractical design. This paper gives a detailed study on testing prioritization technique, which is referred to as CIPC. As there are dependencies between services from API gateway logs, a novel CIPC algorithm is proposed, which is based on belief propagation. There are some rules that are directly affected by service changes. Therefore, the higher execution order of test case prioritizes CIPC, which is based on impact changes. Multiobjective prioritization algorithm is based on heuristic searching, in which sequence test cases are done by coverage. By evaluating the effectiveness of CIPC, the empirical study presents five microservice systems and four different techniques. The results describe that CIPC has improved fault detection rate with acceptable time and cost. The technique is more practical than typical artifacts, which are based on increments of system scales.
Groundwater Quality Evaluation for Potable Use and Associated Human Health Risk in Gaobeidian City, North China Plain
Authors: Fu Xiaogang , Dong Zihan , Gan Shuang , Wang Zhe , Wei Aihua
Published: November 2021

The groundwater in Gaobeidian city is used for drinking, irrigation, industrial production, and other purposes. With the rapid development of the economy and urbanization, groundwater quality has been seriously affected. The main purposes of this paper are to evaluate the groundwater quality in the study area on the basis of understanding the hydrochemical characteristics of the study area and assess the possible health risks of groundwater to children and adults. In this paper, the entropy weight method was used to determine the weight of each evaluation parameter, and on this basis, groundwater quality evaluation was carried out, and the spatial distribution map of groundwater quality was drawn according to the evaluation results. The results show that the weight values of the five parameters of NO2–, Fe, As, Cr6+, and NO2–N are more than 0.1 among the total of fifteen parameters, and the concentration of these five parameters can be considered as the main influencing parameters of groundwater quality. The calculation results of the entropy weighted water quality index (EWQI) show that all the groundwater quality in the study area is class 1 water, which is Excellent Water. However, the EWQI value is the highest in the southwest of the study area, showing a trend of deterioration of groundwater water quality. Since all groundwater samples were evaluated as “excellent water,” it was speculated that the natural environment had more influence on groundwater chemical characteristics than human factors. The study found that 7.407% and 55.556% of the water samples posed a noncarcinogenic health risk to adults and children, respectively. The main responsible parameters for noncarcinogenic risk are F−, NO2−, NO3−, and Cr6+. The carcinogenic risk for adults ranged from 0 to 6.91E-04, with a mean of 1.00E-04. The carcinogenic risk for children ranged from 0 to 1.03E-03, with a mean of 1.55E-04. These toxic elements are mainly from industries. Therefore, the deterioration of groundwater quality can be prevented by strengthening the sewage management of various industries.
Simultaneously Remove and Visually Detect Ce4+ Based on Nanocomposite of UiO-66-NH2/CPA-MA
Authors: Tang Xiaoqiu , Wu Guanghui , Wang Tao , Chen Pinghua , Chen Jiezeng , Jiang Hualin
Published: November 2021

Effective strategies to deal with rare earth pollution are urgently needed due to the overexploitation of rare earths resource. In this study, a novel nanocomposite of UiO-66-NH2/CPA-MA denoted as UA was successfully synthesized, which can simultaneously remove and detect Ce4+ in water. The hybrid consists of UiO-66-NH2 and CPA-MA. Based on the high adsorption performance of UiO-66-NH2, it can remove Ce4+ with high capacity by adsorption. Moreover, it can change its color from olive drab to light cyan depending on the adsorbed Ce4+ concentration, and the chroma is linearly related to the Ce4+ concentration. So, UA can be used to qualitatively and quantitatively detect Ce4+ by its color changing. The kinetics of adsorption course was investigated in details. The anti-inference ability of the nanocomposite in coexisting systems was carefully evaluated. The results indicate that UiO-66-NH2/CPA-MA is highly potential to deal with Ce4+ pollutions due to its bifunctionality.
Effects of Upregulation of TNFAIP3 on Diabetic Neuropathic Pain in Mice
Authors: Liu Yang , Li Jinhe , Yao Hongbo , Zhang Meng , Lian Jie , Zhang Haiyan , Zhang Keshuang , Liu Danyang , Chen Jiwei , Wang Yuejing , Gao Yin
Published: November 2021

Globally, diabetes has assumed epidemic proportions with the neuropathic complications attributed to the malady emerging as a substantial burden on patients and society. DNP has greatly affected the daily life of patients, the effect of traditional treatment methods is not ideal, and it is easy to produce drug resistance. This work is aimed at scrutinizing the effect of upregulating the expression of TNFAIP3 on diabetic neuralgia in mice. This work entailed ascertaining the effects of TNFAIP3 on a murine DNP system. This inspired us to observe the analgesic effect via high expression of lentivirus-mediated TNFAIP3 by intrathecal injection in the animal model to explore its regulatory impacts, symptom relief, and mechanistic role in pain. The results displayed an attenuation of hind paw pain hypersensitivity by LV-TNFAIP3 in the animals. The spinal cord and dorsal root ganglion of mice with neuropathic pain displayed an evident dip in TNFAIP3. Inhibition of the ERK/NF-κB signaling pathway employing LV-TNFAIP3 conspicuously suppressed this pathway while the diabetic pain hypersensitivity was quelled. This effect was also seen with insulin treatment evidently. In conclusion, according to the above analyses, the interaction between DNP and extracellular signal-regulated kinase signal transduction pathway is one of the key factors of pathogenesis.
High-Performance Computational Early Warning Analysis of Agricultural Economy Relying on Binary Fuzzy Cluster Analysis Algorithm
Authors: Tang Fang
Published: November 2021

In this paper, a binary fuzzy cluster analysis algorithm is used for an in-depth study and analysis of high-performance computational early warning in the agricultural economy. The definition of interval type-two fuzzy set and its operation are summarized. Considering the uncertain information that will be encountered in the evaluation process, this paper constructs the evaluation model of rural informatization construction performance based on interval type-two fuzzy numbers, which improves the accuracy of the evaluation results. The fuzzy clustering centres are modified according to the nature of the fuzzy clustering centre matrix, and the optimal fuzzy clustering centres and optimal fuzzy clustering division matrix with consistent order are solved. Using the level eigenvalues to find out in the abundant water period, there are 4 monitoring sections of water quality evaluation results for still clean and 5 monitoring sections of water quality evaluation results for slight pollution. In the flat-water period, there are 2 monitoring sections of the water quality evaluation results that are still clean and 7 monitoring sections of the water quality evaluation results are slightly polluted. In the dry water period, the water quality evaluation results of the 9 monitoring sections are slightly polluted. The results and the use of integrated pollutant index evaluation method results are consistent, indicating that the use of fuzzy clustering model for water quality evaluation is practical and effective. Its functional structure includes management business, innovation business, service business, production business, and operation business functions, in addition to the design of the collection and storage scheme based on Hadoop data warehouse, to achieve accurate matching of information of science and technology agricultural services in the whole agricultural industry chain. Finally, the implementation and maintenance of the cloud-based science and technology agricultural service information system are deployed, and the operational effects of its information system-related functions are demonstrated using prototype design. This paper constructs a comprehensive information system for science and technology agricultural services based on cloud technology that integrates management, innovation, service, production, and operation, which meets not only the needs of traditional science and technology agricultural service information systems, such as expert consultation and training demonstration, but also other needs spawned by the development of agricultural modernization.
A New Environmentally Friendly Utilization of Energy Piles into Geotechnical Engineering in Northern China
Authors: Peng Jianguo , Li Qingwen , Huang Chungho
Published: November 2021

In the past 30 years, because of built‐in advantages, energy saving, pollution control, and sustainability, the energy pile system has had a rapid development around the world. Many scholars did numerous researches on the parameters’ optimization, heat exchange efficiency, and structure‐soil response. Also, the researches of evolutional GSHP system using high temperature in deep mine and lager collection surface of tunnel lining were learned. At present, most of researchers are discussing the geothermal collection for the heating or cooling the building, and plenteous and significant research achievements have been obtained. It is a novel attempt to apply energy pile to geotechnical engineering, and good results have been achieved in engineering practice in Northern China. The area of northern China is a typical seasonal frozen region: the high temperature in summer and the cold weather and accumulated snow in winter will result in huge challenge and resource consumption of maintaince on highway tunnel, pavement, and other geotechnical engineering facilities. In this paper, taking example of using the geothermal heat exchanger to melt snow, the novel idea of using energy piles to prevent track in summer and crack in winter of pavement, and guaranteeing the safety of frost crack on tunnel lining were discussed. Also, through simulation research, we propose a buried pipe form with good heat transfer uniformity‐spiral buried pipe, which has better engineering applicability. This shows us that the application of energy pile in geotechnical engineering will provide solutions to geotechnical problems, which will have a brilliant future.
The Impact Behavior between Coal Gangue Particles and the Tail Beam Based on Rock Failure
Authors: Xin Zhengyuan , Zeng Qingliang , Yang Yang
Published: November 2021

In top coal caving mining, common impact occurs between coal gangue particles and tail beam. Little attention has been paid to the effects of coal gangue particles failure on impact force and tail beam response theoretically, numerically, and experimentally. This paper aims to reveal the influence of coal gangue particles failure on the impact effect of tail beam. First, this paper incorporates the theory of rock failure and energy consumption to assess the impact process of coal gangue particles on the tail beam. A new model to simulate the actual failure conditions of rock particles was developed: the brittle damage‐fracture particle model. By comparing damage phenomena and simulation data, the brittle damage‐fracture particle model was proved to be correct. Based on this model, a dynamic simulation of brittle coal gangue particles impacting the tail beam was conducted. Then, the dynamic responses of the particles and tail beam were analyzed. The results show that particle failure significantly affects the impact force and dynamic response of the tail beam. The impact effects of coal and gangue particles on the tail beam and their failure energy consumption also differed significantly. This paper stresses the importance of coal gangue particle failure conditions for research on top coal caving mining. Theoretical support is provided for the research of coal gangue identification technology based on the tail beam vibration signal.
Efficacy of Restricting Dietary Protein Intake Combined with Buyang Huanwu Decoction in Treating Diabetic Nephropathy and Its Effect on Patients’ Inflammatory Factor Levels
Authors: Chen Dan , Huang Dan , Hu Taotao , Chen Fang
Published: November 2021

Objective. To study the efficacy of restricting dietary protein intake combined with Buyang Huanwu decoction in treating diabetic nephropathy (DN) and its effect on patients’ inflammatory factor levels. Methods. The medical data of 150 DN patients treated in Wuhan No.1 Hospital (June 2018—May 2021) were retrospectively analyzed. All patients received regular therapy, those who received the intervention of restricting dietary protein intake were included in the control group (n = 75), and on this basis, those treated with Buyang Huanwu decoction were included in the experimental group (n = 75), so as to scientifically evaluate their efficacy and inflammatory factor levels after treatment. Results. The patients’ general information was not statistically different between the two groups (

P
>
0.05

); after treatment, the experimental group gained remarkably higher marked effective rate and total effective rate of treatment than the control group (

P
<
0.05

); the inflammatory factor levels of all patients were obviously better than before (

P
<
0.05

), and the levels of TNF-α, IL-2, IL-8, IL-4, and IL-10 were obviously lower in the experimental group than in the control group (

P
<
0.05

); the levels of fasting blood glucose, 2 h postprandial blood glucose, and glycosylated hemoglobin of all patients were remarkably lower than before (

P
<
0.05

), but with no significant between-group difference (

P
>
0.05

); the renal function indexes of all patients were better than before, and between the two groups, the levels of 24 h microalbuminuria, 24 h urine protein excretion, and serum creatinine were obviously lower and the glomerular filtration rate was significantly higher in the experimental group (

P

all <0.05), and the patients’ traditional Chinese medicine (TCM) symptom scores were remarkably lower in the experimental group (

P
<
0.05

). Conclusion. Jointly applying Buyang Huanwu decoction on the basis of restricting dietary protein intake can effectively promote the clinical efficacy of DN, which is conducive to adjusting the inflammatory factor levels, promoting the patients’ renal function, and alleviating the clinical symptoms.
The Determination of Type 2 Diabetes Mellitus’s Impact on the Density of Retinal Blood Vessels and the Choriocapillaris: Optical Coherence Tomography Angiography Study
Authors: Zlatanović Marko , Đorđević Jocić Jasmina , Jakšić Vesna , Zlatanović Nevena , Golubović Mlađan , Živković Maja
Published: November 2021

Optical coherence tomography angiography (OCTA) was used to analyze the alterations in the density of retinal blood vessels and the choriocapillaris (VD) in patients suffering from type 2 diabetes mellitus (T2DM). One hundred sixty-six eyes of 83 patients (43 of whom were men and 40 women, with a mean age of 58.59 ± 14.04) with T2DM and without diabetic retinopathy were examined for the purpose of conducting the observational prospective study. The control group (CG) consisted of 66 eyes in 33 healthy subjects (15 male and 18 female, with a mean age of 55.12 ± 12.70). The measurement regions of vessel density (VD) included the deep capillary plexus (DCP), the superficial capillary plexus (SCP), and the choriocapillaris. The results indicate considerable differences in the VD of the DCP and SCP when comparing the control group with the study groups (

p
<
0.001

). In comparison with the control group (

p
<
0.001

), there was a statistically significant reduction in the VD of the choriocapillaris in the study group. Furthermore, patients with T2DM showed a significantly decreased VD concerning the control in different macular regions. Thickness in several macular regions in the study group significantly decreased compared to the ones in the control group. OCTA was used to gather relevant information about the vascular changes which occurred in T2DM patients, assessed through the quantitative analysis of the blood flow in the retina and choriocapillaris.
Study on Deep and Large Foundation Pit of a National First‐Class Key Tomb Protection Project
Authors: Zhang Jiagang , Chen Zhimin , Hu Mingzhu , Wu Zhaoguo
Published: November 2021

For the support engineering of the deep and large foundation pit (DLFP) due to tomb protection, there are still no clear standards. The construction of DLFP will introduce large‐range transverse and longitudinal disturbance on the stratum; therefore, it should be reinforced. In this paper, the reinforcement of the deep and large foundation pit of a national first‐class key tomb protection project is studied. By comparing the existing supporting scheme and the stress conditions of the reinforced tomb, the combination reinforcement scheme by bored pile and pile slab retaining wall is found to be safe and feasible. Furthermore, according to the simulated bending moment, displacement, and axial force of the tomb by numerical analysis, an economic and reasonable mixed anchor support scheme is selected. In order to ensure the stability of the tomb during the supporting process of the foundation pit, a maximum value of 10 mm for the overall settlement of the tomb can be treated as the control benchmark based on the support and anchorage schemes in each specification and the in‐site measured settlement values of the tomb. The determined support, anchorage schemes, and the control benchmark can provide certain technique guidance and research significance for the protection of similar ancient buildings in the future.
Biomarkers and Mechanism Analysis for Polygoni Multiflori Radix Preparata-Induced Liver Injury by UHPLC-Q-TOF-MS-Based Metabolomics
Authors: Wang Liming , Wang Zhida , Xing Yanchao , Liu Erwei , Gao Xiumei , Wang Linlin , Fu Zhifei
Published: November 2021

Background. Polygonum Multiflorum Radix Preparata (PMP), prepared from Polygonum multiflorum Thunb. (PM), is traditionally valued for its liver and kidney-tonifying effects. However, the previous studies showed that PMP was hepatotoxic, which limited its clinical use. Unfortunately, the potential hepatotoxic ingredients and the molecular mechanism are still uncertain. Objective. The aim of this study was to find out potential biomarkers of hepatotoxicity using metabolomics profile. Materials and Methods. 60% ethanol extract of PMP (PMPE) was prepared. Subsequently, an untargeted metabolomics technology in combination with ROC curve analysis method was applied to investigate the alteration of plasma metabolites in rats after oral administration of PMPE (40 g/kg/d) for 28 days. Results. Compared to the control group, the significant difference in metabolic profiling was observed in the PMPE-induced liver injury group, and sixteen highly specific biomarkers were identified. These metabolites were mainly enriched into bile acids, lipids, and energy metabolisms, indicating that PMPE-induced liver injury could be related to cholestasis and dysregulated lipid metabolism. Conclusions. This study is contributed to understand the potential pathogenesis of PMP-induced liver injury. The metabonomic method may be a valuable tool for the clinical diagnosis of PMP-induced liver injury.
Machine Learning-Based Gynecologic Tumor Diagnosis and Its Postoperative Incisional Infection Influence Factor Analysis
Authors: Shen Qian , Wang Ling
Published: November 2021

Various factors influencing postoperative incisional infection in gynecologic tumors were analyzed, and the value of quality nursing intervention was studied. In this study, 74 surgically treated gynecologic tumor patients were randomly selected from within the hospital as the study population and were divided into study and control groups. For this purpose, the whole-group random sampling method is utilized to compare the postoperative incisional infection rates of the two groups, analyze their influencing factors, and develop quality nursing interventions. In this paper, a breast cancer diagnosis prediction model was developed by combining the self-attentive mechanism. The preprocessing work such as data quantification and normalization was performed first which is followed by adding the preprocessed data to the self-attentive mechanism. This model has solved the problem that recurrent neural networks (RNNs) could not extract and calculate the features at the same time. Likewise, it has solved the drawback that the RNN could not consider global features at the same time when extracting the features, and then, the feature matrix extracted by the self-attentive mechanism was added to the adaptive neural network. The adaptive neural network model for breast cancer diagnosis prediction was constructed and, finally, relevant parameters of the adaptive neural network model were adjusted according to different tasks to make the model performance optimal. Experimental results showed that the postoperative incision infection rate of patients in the study group was 2.70%, which was significantly lower than that of 21.62% in the control group (

P
<
0.05

). Likewise, operation time, operation method, hospitalization time, preoperative fever, diabetes mellitus, and anemia were the main influencing factors of postoperative incision infection in women with gynecologic tumors. The time of surgery, surgical method, long hospital stay, preoperative fever, diabetes, and anemia are the main factors that lead to postoperative incisional infection in female gynecologic tumor patients.
Some Bohr-Type Inequalities for Bounded Analytic Functions
Authors: Wang Hong
Published: November 2021

In this paper, some new versions of Bohr-type inequalities with one parameter or involving convex combination for bounded analytic functions of Schwarz function are established. Some previous inequalities are generalized. All the results are sharp.
Study of Displacement Characteristics of Fire Flooding in Different Viscosity Heavy Oil Reservoirs
Authors: Liu Bingyan , Liang Jinzhong , Zhao Fang , Liu Tong , Qi Zongyao , Liu Fengchao , Liu Pengcheng
Published: November 2021

A field test in the Xinjiang oilfield in China shows that the viscosity of heavy oil has a certain influence on the combustion dynamics and injection-production performance of fire flooding. The experiment in this study uses a one-dimensional combustion tube to study the temperature, gas composition, and air injection pressure and the production performance of the fire flooding of heavy oil with different viscosities. The results show that the oil viscosities of 1180–22500 mPa·s can achieve stable combustion, and the O2 content of the gas produced during the stable combustion stage is <0.5%. The higher the viscosity of the heavy oil, the higher the temperature in the burned zone and the smaller the range of the temperature increase in the unburned zone. The air injection pressure will increase rapidly until a stable seepage channel is formed, and then, it will drop to a level close to the formation pressure. High-viscosity heavy oil requires a higher air injection pressure and will remain in the high-pressure stage for a longer period of time. Low-viscosity heavy oil has a low water cut in the early stage of fire flooding, a large oil production rate, and a low and stable air–oil ratio. The water cut of high-viscosity heavy oil increases rapidly in the early stage of fire flooding and then decreases gradually, so a good air–oil ratio can only be obtained in the middle and late stages of fire flooding. Thus, fire flooding may be more suitable for application in common heavy oil and some extra heavy oil reservoirs with lower viscosities.
Effect of Sports Nutrition Supplement on the Increase of Physical Strength Based on Mobile Sensor Network Technology
Authors: Zhang Runping , Hong Xue
Published: November 2021

With the development of signal processing technology and the appearance of small, low‐cost, and low‐power microprocessors, mobile sensor networks have begun to emerge in large numbers. In view of the different exercise abilities of different body components, mobile network sensor technology is used to monitor various data. Lean body mass is positively correlated with physical strength, aerobic capacity, and maximum oxygen uptake and is the main factor affecting explosive power, speed, and endurance. This article mainly studies the effect of nutritional supplementation in sports on physical strength. The subjects in this article are 10 male physical athletes. Three solid sports drinks with different nutrient composition ratios were selected from the national team’s nutrition centralized procurement product list, and a placebo with sugar‐free sweetener and purified water was used as a control group. The test measures the maximum oxygen uptake to determine the exercise intensity during the formal exercise test. Each stage includes exercise test day and washout period. Eat on the test day and provide a one‐hour static rest after a unified breakfast, and then, perform a 1‐hour power bicycle riding after the rest. During 0, 15, 30, and 45 minutes of exercise, drink the designated solution at 1.8 mL/kg body weight and record it as the corresponding solution group. Within 30 minutes immediately after the end of the cycling exercise, fluids should be refilled at 10 mL/kg of body weight. Experimental data showed that the levels of lactic acid in each group increased significantly after exercise compared to those at rest (P < 0.05), and there was no difference between the groups. There was no significant difference in the duration of the exercise ability test between the sports drink group and the placebo group. The experiment in this article shows that athletes can take appropriate measures to improve athletes’ physical activity level, increase daily energy consumption and a reasonable and balanced diet, which can effectively reduce the athlete’s body fat percentage, improve, and maintain a reasonable body composition. Among all the monitoring actions, the monitoring results indicate that the evaluation value of the action of combat is the highest, reaching 8.7.
An Analysis of the Progression of Conjunctivalisation after Transplantation of Cultivated Corneal Epithelium
Authors: Dobrowolski Dariusz , Orzechowska-Wylegala Boguslawa , Wowra Bogumil , Wróblewska-Czajka Ewa , Grolik Maria , Wylegala Edward
Published: November 2021

Purpose. To analyse the recurrence of superficial neovascularisation after previous corneal surface reconstruction with cultivated corneal epithelial cells. Materials and Methods. Forty-eight eyes underwent autologous transplantation of cultivated corneal epithelium to treat partial or total limbal stem cell deficiency caused by chemical or thermal injury. The carrier for the epithelial sheets was a denuded amniotic membrane. Follow-up was conducted for up to 120 months. Recurrent revascularisation (measured in terms of clock hours affected) was evaluated with slit-lamp examination and the support of confocal microscopy. Results. During the long-term observation, only 7 eyes had stable epithelia with no neovascularisation from the conjunctiva. Nineteen eyes developed pathologic vessels in 1 quadrant, with additional 4 eyes developing them in 2 quadrants. Twelve patients developed subtotal or total conjunctivalisation of the corneal surface. They were referred for second cultivated epithelium transplantation (3 patients), allogenic keratolimbal transplantation (7 patients), or keratoprosthesis (2 patients). Six patients withdrew consent. The use of confocal scans of up to 100 µm in resolution enabled the detection of pathologic microvasculature originating from the conjunctiva and the exclusion of stromal vascular ingrowth. Conclusions. Local ingrowth of the conjunctiva is a common complication after the transplantation of cultivated epithelial cells. Severe and progressive vascularisation inevitably leads to graft failure. However, if local ingrowth stops before reaching the central cornea, the treatment even with this complication can be considered a success.
Mobile Information System for English Teaching Based on Edge Computing and VR
Authors: Zhou Yanfang
Published: November 2021

There are many difficulties in using cloud computing technology to solve this problem, and edge computing technology just provides an effective way to solve this problem. Changing from two-dimensional to three-dimensional will make education more realistic. This article uses the VR technology algorithm to design and analyze the English teaching system, combined with the current environment and requirements, in the construction of teaching resources, in order to clarify the direction in practical application. Secondly, according to the scene of human behavior recognition, a human behavior data collection, processing and analysis system based on edge computing is designed and implemented. And on the basis of detailed analysis of VR technology, the theoretical basis of VR technology applied to experiment teaching is discussed, and the development of virtual experiment is analyzed concretely using systematic teaching design ideas. VR technology greatly stimulates students’ learning motivation but also significantly improves their interest in learning. In addition, the application of virtual technology has greatly improved students’ learning enthusiasm. According to the findings of this article, based on the application of virtual reality technology, students’ English comprehension skills have increased by 19%, and the degree of resource sharing has increased by 11%.
FAPI-04 Uptake in Healthy Tissues of Cancer Patients in 68Ga-FAPI-04 PET/CT Imaging
Authors: Gündoğan Cihan , Güzel Yunus , Can Canan , Kaplan İhsan , Kömek Halil
Published: November 2021

Objective. The aim of this study is to investigate the uptake of 68Ga-FAPI-04 in normal tissues and calculate standardized uptake values (SUVs) for various organs in the body. Methods. A total of 49 patients who underwent 68Ga-FAPI-04 PET/CT were included in our study. The following organs were identified on CT images: brain, parotid, and submandibular glands, palatine tonsils, thyroid, lymph nodes (if present), breasts, lungs, thymus, left ventricle walls, mediastinal blood pool, vertebral bone marrow, liver, spleen, pancreas, stomach, small and large intestines, adrenal glands, kidneys, uterus, testes, and prostate. Median, minimum, and maximum values (max) and average (avg) values of standard uptake value (SUV) of tissues and organs were calculated. Results. The accumulation of 68Ga-FAPI in normal organs showed variations. The cerebral/cerebellar cortex exhibited no 68Ga-FAPI uptake, while the scalp showed low uptake. Low uptake was also observed in the lung parenchyma, esophagus, left ventricle walls, nipple, and glandular breast tissue. In the abdominopelvic area, the pancreas exhibited low uptake, which was higher in the tail region. Low uptake was observed in the renal cortex. Intense 68Ga-FAPI uptake was observed throughout the uterus, which was higher in the corpus. There was no uptake of 68Ga-FAPI in the bone cortex and medulla. Conclusion. We determined the physiological uptake and SUVmax of FAPI-04 in different tissues and organs and created a guide for researchers.
Decision Regret and Quality of Life after Focal Therapy with Vascular-Targeted Photodynamic Therapy (TOOKAD®) for Localized Prostate Cancer
Authors: Flegar Luka , Baunacke Martin , Buerk Bjoern Thorben , Proschmann Rick , Zacharis Aristeidis , Propping Stefan , Huber Johannes , Thomas Christian , Borkowetz Angelika
Published: November 2021

Purpose: The aim of the study was to assess quality of life (QoL), decision involvement, and decisional regret after treatment with vascular-targeted photodynamic therapy (VTP) (TOOKAD®) for unilateral low-risk prostate cancer. Methods: Validated questionnaires (EORTC QLQ-C30 and QLQ-PR25) capturing QoL post-treatment, involvement in decision-making (Control Preferences Scale) and decision regret (Decisional Regret Scale), were given to patients at the 12-month visit after undergoing VTP at our institution between May 2018 and February 2021. Results: Out of 44 patients, 36 patients were included in this study and 31 (86.1%) responded to the questionnaires. Mean overall health score capturing QoL at 12 months was 79.3 (standard deviation: ±18.1). 70.9% of the patients (n = 22) had no decision regret, and 67.8% of men (n = 21) had an active role in decision-making. In control biopsy at 12 months post-treatment, 19.4% of patients (n = 7) presented with local recurrence and progression to higher Gleason score (GS) was found in 13.8% of patients (n = 5). Patients (n = 3) presenting with tumor recurrence or progression to higher GS in control biopsy showed a significantly higher level of decision regret (p < 0.009). Conclusion: Only 9.7% of men (n = 3) felt a strong emotion of regret at 12 months after VTP. Level of decision regret was significantly higher in patients with local recurrence or tumor progression detected in control biopsy. QoL was stable after VTP.
A Case Report of Vitiligo Induced by Alexandrite Hair Removal Laser
Authors: Alkhalifah Azzam
Published: November 2021

Vitiligo is one of the disorders where we usually see Koebner lesions. Lasers target a chromophore in the skin to deliver their energy. Their effect is theoretically considered as injury and may induce Koebner lesions in vitiligo patients. Few cases were reported with the different kinds of laser, including laser hair removal (LHR). No cases have ever been reported of vitiligo lesions induced by Alexandrite LHR. Here we present a case report of a young female patient who had never had vitiligo until she received a 755-nm LHR treatment. These vitiligo lesions were completely treated with NB-UVB with no recurrence until 4 years later when she received another 755-nm LHR treatment session with a different machine, which lead to new vitiligo patches only on the areas that received the laser.
Ergebnisse einer deutschlandweiten Befragung zum derzeitigen chirurgischen Vorgehen bei Zervixkarzinom im Frühstadium NOGGO MONITOR 11
Authors: Armbrust Robert , Chen Frank , Richter Rolf , Zela Muallem Mustafa , Mustea Alexander , Holthaus Bernd , Sehouli Jalid
Published: November 2021

Die minimalinvasive Chirurgie (MIC) ist mittlerweile das Standardverfahren bei frühem Zervixkarzinom (early stage cervical cancer, ECC). Die kürzlich veröffentlichte LACC-Studie zeigte jedoch ebenso wie andere Untersuchungen, dass die MIC in Hinblick auf das progressionsfreie Überleben (progression-free survival, PFS) und das Gesamtüberleben (overall survival, OS) gegenüber der offenen radikalen Hysterektomie unterlegen ist. Diese Ergebnisse lösten eine breite Debatte über die beste chirurgische Vorgehensweise bei ECC aus. Mit der vorliegenden Befragung sollten erste Erkenntnisse nach der Veröffentlichung gewonnen werden. Dazu führten die Nord-Ostdeutsche Gesellschaft für Gynäkologische Onkologie (NOGGO) und die Arbeitsgemeinschaft Gynäkologische Endoskopie (AGE) eine bundesweite digitale Befragung unter 186 gynäkologischen Krebszentren durch. Mithilfe von SPSS wurden deskriptive statistische Kennzahlen ermittelt und t-Tests durchgeführt. Die meisten Zentren hatten eine hohe Expertise und/oder Erfahrung in der Behandlung von ECC und waren über die Ergebnisse der LACC-Studie sehr gut informiert. Die Qualität und die wissenschaftliche Bedeutung der Studie wurden als sehr gut/gut eingestuft. Trotzdem würden immer noch 40 % keine Umstellung der Standardbehandlung auf eine offene Operation vornehmen. Zentren mit höherem Fallvolumen, die zudem an klinischen Studien teilnahmen, waren eher bereit, die Behandlung umzustellen. Diese Befragung gibt Einblicke zu den überraschenden Ergebnissen der kürzlich veröffentlichten Studien zum chirurgischen Vorgehen bei ECC. Wie es scheint, ist die Notwendigkeit zukünftiger Studien und möglicher Erklärungen für die unerwartet schlechteren Outcomes in der MIC-Gruppe weiterhin hoch.
Ösophaguskarzinom: Die adjuvante Immuntherapie verbessert die Zeit bis zum Rezidiv bei Risikopatienten mit histologischem Tumorrest nach präoperativer CRT und Operation signifikant
Authors: Stahl Michael Konrad
Published: November 2021

CheckMate 577 ist eine globale, randomisierte, doppelblinde, placebokontrollierte Phase-III-Studie. Erwachsene mit reseziertem (R0) Speiseröhren- oder Magen-Darm-Krebs im Stadium II oder III, die eine neoadjuvante Chemoradiotherapie erhalten hatten und bei denen eine pathologische Resterkrankung vorlag, wurden im Verhältnis 2:1 in zwei Behandlungsarme randomisiert. Der primäre Endpunkt war das krankheitsfreie Überleben. Die Patientengruppen erhielten entweder Nivolumab in einer Dosis von 240 mg alle 2 Wochen über 16 Wochen, gefolgt von Nivolumab in einer Dosis von 480 mg alle 4 Wochen oder ein entsprechendes Placebo. Die mediane Nachbeobachtungszeit betrug 24,4 Monate. Die Studienautoren schlussfolgern, dass bei Patienten mit reseziertem Speiseröhrenkrebs oder Krebs des gastroösophagealen Übergangs, die eine neoadjuvante Chemoradiotherapie erhalten hatten, das krankheitsfreie Überleben unter der adjuvanten Therapie mit Nivolumab signifikant länger ist als unter Placebo. Basierend auf den Ergebnissen der CheckMate 577 Studie erteilte Mitte 2021 die Europäische Kommission die Zulassung für Nivolumab zur adjuvanten Behandlung erwachsener Patienten mit Karzinomen der Speiseröhre oder des gastroösophagealen Übergangs, bei denen nach einer neoadjuvanten Chemoradiotherapie noch eine pathologische Resterkrankung vorliegt.