bluuebunny/crossref_metadata_2025 huggingface dataset:
Benign Endikasyonlarla Histerektomi Uygulanan Hastalarda Okült Malignensi Prevalansı: 3. Basamak Bir Hastanede 5 Yıllık Deneyim
Authors: Gümüşburun Neşet , Üskent Ulya
Published: May 2024

Histerektomi, tüm dünyada sezaryen sonrası en sık uygulanan jinekolojik cerrahi prosedürdür. Histerektomi için en yaygın endikasyon myoma uteri'dir ancak nihai patoloji sonuçlarında okült maligniteler bulunabilir. Bu makalede, benign endikasyonla histerektomi yapılan hastaların patoloji sonuçlarını analiz etmeyi, histerektomi spesimenlerinde okült malignite saptanan hastaları gözden geçirmeyi ve preoperatif değerlendirmede dikkat edilmesi gereken konuları literatür ışığında tartışmayı amaçladık. Gaziosmanpaşa Üniversitesi Kadın Hastalıkları ve Doğum Anabilim Dalı'nda 2017 - 2021 yılları arasında histerektomi yapılan 593 hastanın verileri toplandı. Preoperatif malignite ve postpartum histerektomi dışlama kriterleriydi. Histerektomi endikasyonları ve okült malignite prevalansları incelendi. Uterin myom en sık(%40) histerektomi endikasyonuydu. Okült malignite 593 hastanın 7'sinde(%1,2) tespit edildi. Okült malignitesi olan 7 hastanın 3'ünde sarkom, 1'inde servikal, 2'sinde over ve 1'inde tubal kanser vardı. Leiomyom ve anormal uterin kanama nedeniyle histerektomi yapılan hastaların preoperatif endometriyal biyopsileri normaldi. Hiçbir hastada endometriyal kansere rastlanmadı. Uterin sarkom ve over kanseri için preoperatif tarama kılavuzları olmamasına rağmen, çalışmamız özellikle yaşlı hastalarda benign endikasyonlarda dahil olmak üzere dikkatli preoperatif değerlendirme yapılması gerektiğini vurguladı.
Fibromiyalji Sendromunda Sistemik İmmün-İnflamasyon İndeksi ve Hematolojik Laboratuvar Bulgularına Genel Bakış
Authors: Ellergezen Pınar , Alp Alev , Çavun Sinan , Sevdar Çeçen Gülce
Published: May 2024

Bu çalışmada fibromiyalji sendromunda (FMS) Sistemik İmmün-İnflamasyon İndeksi (SII) ile kan parametreleri arasındaki ilişki değerlendirilerek hastalık aktivitesinin belirlenmesi amaçlanmıştır. Çalışmaya Ocak 2021 ve Ocak 2022 tarihleri arasında Fizik Tedavi ve Rehabilitasyon Kliniğine başvuran 109 FMS hastası ve 82 sağlıklı kontrol dahil edilmiştir. Yaş, cinsiyet, C-reaktif protein (CRP), eritrosit sedimentasyon hızı (ESR), beyaz kan hücresi (WBC), hemoglobin (HGB), ortalama korpusküler hacim (MCV), ortalama korpusküler hemoglobin (MCH), ortalama korpusküler hemoglobin konsantrasyonu (MCHC), kırmızı hücre dağılımı (RDW), trombosit dağılım genişliği (PDW), ortalama trombosit hacmi (MPV), trombosit (PLT), trombosit kriteri (PCT), lenfosit (LYM), monosit (MONO), nötrofil (NEU) düzeyleri hastane bilgi sisteminden retrospektif olarak taranmıştır. Trombosit-lenfosit oranı (PLR), nötrofil-lenfosit oranı (NLR), monosit-lenfosit oranı (MLR) ve sistemik immün-inflamasyon indeksi (SII) hesaplanmıştır. CRP ve ESR düzeyleri FMS hastalarında sağlıklı kontrollere göre daha yüksekti ancak değer aralığının dışında değildi (p<0,001). PDW (p<0,001), HGB (p<0,001), MCV (p<0,001), MCH (p<0,001) ve MCHC (p=0,02) düzeyleri hastalarda sağlıklı gruba göre daha düşüktü. Hasta ve kontrol grupları arasında yaş, WBC, NEU, LYM, MONO, RDW, MPV, PLT, PCT, SII, PLR, NLR ve MLR değerleri açısından istatistiksel olarak anlamlı fark yoktu. FMS hastalarında WBC düzeyleri ile SSS değerleri arasında (r=0,2; p=0,005) ve lenfosit düzeyleri ile WPI değerleri arasında (r=0,2; p=0,01) anlamlı pozitif korelasyon bulunmuştur. Çalışma sonuçlarına göre, SII'nin FMS'de belirleyici bir rolü yoktur, ancak hastalığın tanıda yararlı olabilecek bazı inflamatuvar bileşenleri vardır ve daha ayrıntılı çalışmalara ihtiyaç vardır.
Kristologija u Evanđelju po Ivanu kao okidač za učeništvo
Authors: Budiselić Ervin
Published: May 2024

U ovome članku razmatra se tema učeništva u poveznici s kristologijom budući da se ističe kako je kristologija pokretač ili okidač za to da netko postane Isusov učenik te se ponekad koristi i za revitalizaciju učenika. U svrhu dokazivanja ove teze, u prvome dijelu članka istražuje se korištenje pojma mathētēs: koga se sve direktno ili indirektno naziva Isusovim učenikom. U drugome dijelu članka istražuju se pojmovi koji spadaju u domenu učeništva, a sve to služi kao temelj za treći dio članka u kojemu se istražuje zašto netko postaje Isusov učenik, tj. što je to što neku osobu potakne ili motivira da postane Isusovim učenikom. Zbog širine same teme, u ovome dijelu razmatraju se samo dijelovi evanđelja u kojima se javljaju eksplicitne kristološke titule i gdje je odgovor na Isusovu osobu pozitivan. Budući da u Evanđelju po Ivanu kristologija pokreće učeništvo, u četvrtom dijelu razmatra se je li primarni sadržaj poruke evanđelja kristologija ili soteriologija te kako različite poruke evanđelja utječu na učeništvo. U članku se zaključuje kako Ivanovo evanđelje zorno pokazuje da je središte poruke evanđelja kristologija, a ne čovjek, njegovo palo stanje i potreba za spasenjem, kako je kristologija okidač za učeništvo te kako je kristologija ključna u današnjoj crkvi za motiviranje vjernika na predanje, revnost, posvećenje i požrtvovno služenje.
Sistemas de gestión de calidad en instituciones educativas. Aplicación de la norma ISO 9001:2008 en el Centro Universitario de la Costa Sur
Authors:   Universidad de Guadalajara, de la Torre Cruz María del Rosario , Bejarano Palomera Ruth Ileana
Published: May 2024

Con el fin de conducir y operar una organización en forma exitosa se requiere que ésta se dirija y controle en forma sistemática y transparente. En una institución educativa, el diseño y desarrollo de un Sistema de Gestión de Calidad (en adelante SGC) contribuye a la estandarización de sus procesos tanto administrativos como académicos, incluyendo el proceso de enseñanza-aprendizaje. El presente proyecto pretende mostrar el diseño de un SGC en una institución educativa y dar a conocer ventajas de dicha implementación.
Emotion Regulation Mediates Functional Impairment in Thai Children with Attention-deficit/ hyperactivity Disorder: A Cross-Sectional Study
Authors: Hosiri Tikumporn , Chukiatiwongul Manapawn , Sumalrot Thanayot , Auampradit Natchaphon , Punyapas Sirinadda , Phattharayuttawat Sucheera
Published: May 2024

Objective: The study investigated the potential mediating effects of emotion regulation and emotion lability/negativity in the relationship between attention-deficit/hyperactivity disorder (ADHD) symptoms and functional impairment while also examining the associations between ADHD symptoms, emotion regulation, and impaired functioning in different life domains among children with ADHD.
Materials and Methods: The clinical sample comprised 118 children diagnosed with ADHD aged 6–12 years. Primary caregivers completed parent reports on symptom severity using the Thai ADHD Screening Scale–Parent Version, assessed emotion regulation and lability/ negativity via the Emotion Regulation Checklist, and evaluated functional impairment using the Weiss Functional Impairment Rating Scale–Parent Version.
Results: ADHD symptoms correlated negatively with overall emotion regulation (r = −0.515, p < 0.01) and positively with lability/negativity (r = 0.583, p < 0.01). Functional impairment exhibited a negative correlation with emotion regulation (r = −0.649, p < 0.01) and a positive correlation with lability/negativity (r = 0.701, p < 0.01). Elevated ADHD symptoms were linked with increased functional impairment (r = 0.639, p < 0.01). The parallel mediational model showed that emotion lability/negativity partially mediated the association between ADHD symptoms and functional impairment (β = 0.282, p < 0.001), suggesting that ADHD symptoms and emotion lability/negativity indirectly accentuate functional impairment. Thus, heightened ADHD symptoms may exacerbate emotion lability/negativity, contributing to increased functional impairments.
Conclusion: Emotion regulation difficulties, particularly emotion lability/negativity, may serve as significant risk factors. Regular monitoring and targeting these challenges hold promise in alleviating adverse functional outcomes co-occurring with elevated ADHD symptoms.
Factors Predicting Psychological Well-being among Survivors of Breast Cancer in A Tertiary Care Hospital, Thailand
Authors: Singtaweesuk Nuntana , Thanoi Wareerat , Vongsirimas Nopporn , Kesornsri Sirada , Klainin-Yobas Piyanee
Published: May 2024

Objective: The primary aim of this study was to examine predicting the effect of stress, social support, self-efficacy, and resilience on psychological well-being in breast cancer survivors
Materials and Methods: This predictive analysis for the descriptive cross-sectional study was conducted by the theoretical underpinning of resilience and population consisted of eligible breast cancer survivors receiving care at an outpatient clinic within a tertiary hospital setting. The data collecting was proceeded through self-administered questionnaires in line with convenient sampling. The analytical approach encompassed descriptive statistics, Pearson’s correlation coefficient, and multiple linear regression.
Results: Emanating from the study included the recruitment of 123 participants, with stress, social support, and resilience collectively elucidating 43% of the variance in psychological well-being among breast cancer survivors. Notably, resilience emerged as the most influential predictor (β=.33), followed by stress (β=-.27) and social support (β=.26), all of which significantly contributed to the prediction of psychological well-being.
Conclusion: Resilience, stress, and social support were three predictors of psychological well-being among survivors of breast cancer in this study. Recommendations extend to the integration of strategies that foster resilience and social support, while concurrently mitigating stress levels through activities and programs aimed at augmenting the psychological well-being of breast cancer survivors in the future.
Simultaneous targeting of B-cell malignancies and human immunodeficiency virus with bispecific chimeric antigen receptor T cells
Authors: Urak Ryan , Pahlavanneshan Saghar , Gittins Brenna , Nakamura Ryotaro , Zaia John A. , Baird John H. , Clark Mary C. , Forman Stephen J. , Wang Xiuli
Published: May 2024

Not available.
DISOBEDIENCE TO REPRESENTATIVES OF THE CORRECTIONAL INSTITUTION ADMINISTRATION: LEGAL NATURE AND DELINEATION FROM CRIMES
Authors: Pleshakov Aleksandr Mihajlovich , Shkabin Gennadij
Published: May 2024

The article examines the legal category of “disobedience to representatives of the administration of a correctional institution.” Group disobedience in the form of strikes, refusal to eat, and acts of autoaggression is analyzed. The article reveals the legal nature and role of the organizer of mass protest actions in places of detention, the causal relationship between the actions of the organizers and the behavior of active participants in malicious violations of punishment. A distinction is made between crimes and disciplinary offenses in the form of organizing groups of convicts aimed at disobeying the administration of a correctional institution and participating in such groups. It is concluded that in any form of legal disobedience there should be no violence or threat of its use, otherwise the illegal behavior of a person can be qualified as disorganization of the activities of institutions that ensure isolation from society.
Patient-reported symptoms in daily oncology practice
Authors:   , Koldenhof Josephine Juliette
Published: May 2024

The number of patients diagnosed with cancer increases. At the same time cancer
patients live longer due to earlier diagnosis and more effective therapies. During
the course of their disease, patients experience many disease and/or treatmentrelated symptoms that impact health-related quality of life and daily functioning.
Symptoms and their impact can be overlooked and/or underestimated by healthcare
professionals. If symptoms remain under-recognized, physical, mental, existential
and social functioning is affected and opportunities for diagnosis and management
of symptoms may be missed. Patient-reported outcome measurement tools (PROMs)
can be used to assess and monitor symptoms and symptom burden.

The Utrecht Symptom Diary is a Dutch translation and modified version of the
Edmonton Symptom Assessment System (ESAS) which is a worldwide frequently
used and validated PROM in cancer patients. In 2003, the USD was developed for daily
assessment and monitoring of symptoms of cancer and/or treatment-related physical
and mental symptoms. It contains a total of 12 items – lack of appetite, nausea,
abnormal stool, dysphagia, dry mouth, pain, sleeping problems, shortness of breath,
fatigue, anxiety, depressed mood and overall well-being. Symptoms are scored on
a zero-to-ten numeric rating scale (NRS), with higher values indicating increasing
intensity. Moreover, patients are invited to add symptoms they experience and are
not listed on the USD and are asked to prioritize symptoms which need attention in
the patient-doctor-nurse conversation first from their personal perspective. Since
2007 treatment and disease specific modules of the USD have been developed. From
2015 the USD became part of the hospital electronic medical files.

Over the last years the USD has been implemented in daily practice in other
departments of the UMC Utrecht as well as in other (university)hospitals, general
practices and hospices in the Netherlands. Moreover, use of the USD is recommended
by the Netherlands Quality Framework for Palliative Care.
This thesis describes the validation of the USD and patient-reported symptoms
through the use of the USD in different patient groups and settings.

The studies described in this thesis show the validity of the USD on content, criterion
and construct level. In collaboration with the patient, the use of the USD gave
insight into symptoms and their impact on quality of life. This insight is essential to
provide personalized, supportive care during treatment with targeted therapies and
immunotherapy in daily oncology practice.
Converting Data Cemeteries into Sources of Knowledge: Is Dentistry a Computable Industry?
Authors: Spallek Heiko
Published: May 2024

In his commentary on EHR, Dr. Heiko Spallek argues that despite our arrival in the age of computation, we are currently experiencing only a slow and gradual increase in our ability to improve the care of our patients and the education of our students. He states these gradual improvements come at a high price.
Preparing Future Clinician-Scientists For the Dental Profession
Authors: Lee Janice
Published: May 2024

Staying current with the biomedical literature and critically examining the evidence for treatment are skills learned in dental school, honed in practice, applied in the day-to-day encounters with patients who seek care, and will ultimatel lead to the improvement of the health of the American population.
A Note from the JADE Editorial Board Chair
Authors: Spivakovsky Silvia
Published: May 2024

This issue of JADE addresses a fundamental question for the profession: "Is the use of human subjects during dental licensing exams the best way to ensure the health and safety of the public?"
Principles of Humility in Educational Technology
Authors: Shirky Clay
Published: May 2024

In "Principles of Humility in Educational Technology," Clay Shirky offers a thoughtful analysis of the uses of educational technology in the higher education environment, basing his argument for "humility" on the premise that "Learning results from what the student does and thinks and only from what the student does and thinks. The teacher can advance learning only by influencing what the student does to learn."
Minimization of metabolic cost of transport predicts changes in gait mechanics over a range of ankle-foot orthosis stiffnesses in individuals with bilateral plantar flexor weakness
Authors: Kiss Bernadett , Waterval Niels F. J. , van der Krogt Marjolein M. , Brehm Merel A. , Geijtenbeek Thomas , Harlaar Jaap , Seth Ajay
Published: May 2024

Neuromuscular disorders often lead to ankle plantar flexor muscle weakness, which impairs ankle push-off power and forward propulsion during gait. To improve walking speed and reduce metabolic cost of transport (mCoT), patients with plantar flexor weakness are provided dorsal-leaf spring ankle-foot orthoses (AFOs). It is widely believed that mCoT during gait depends on the AFO stiffness and an optimal AFO stiffness that minimizes mCoT exists. The biomechanics behind why and how an optimal stiffness exists and benefits individuals with plantar flexor weakness are not well understood. We hypothesized that the AFO would reduce the required support moment and, hence, metabolic cost contributions of the ankle plantar flexor and knee extensor muscles during stance, and reduce hip flexor metabolic cost to initiate swing. To test these hypotheses, we generated neuromusculoskeletal simulations to represent gait of an individual with bilateral plantar flexor weakness wearing an AFO with varying stiffness. Predictions were based on the objective of minimizing mCoT, loading rates at impact and head accelerations at each stiffness level, and the motor patterns were determined via dynamic optimization. The predictive gait simulation results were compared to experimental data from subjects with bilateral plantar flexor weakness walking with varying AFO stiffness. Our simulations demonstrated that reductions in mCoT with increasing stiffness were attributed to reductions in quadriceps metabolic cost during midstance. Increases in mCoT above optimum stiffness were attributed to the increasing metabolic cost of both hip flexor and hamstrings muscles. The insights gained from our predictive gait simulations could inform clinicians on the prescription of personalized AFOs. With further model individualization, simulations based on mCoT minimization may sufficiently predict adaptations to an AFO in individuals with plantar flexor weakness.
Thermomechanical coupling seepage in fractured shale under stimulation of supercritical carbon dioxide
Authors: Liu Guojun , Shang Delei , Chu Peng , Zhao Yuan , Lu Jun , Li Jianhua
Published: May 2024

As a waterless fracturing fluids for gas shale stimulation with low viscosity and strong diffusibility, supercritical CO2 is promising than the water by avoiding the clay hydration expansion and reducing reservoir damage. The permeability evolution influenced by the changes of the temperature and stress is the key to gas extraction in deep buried shale reservoirs. Thus, the study focuses on the coupling influence of effective stress, temperature, and CO2 adsorption expansion effects on the seepage characteristics of Silurian Longmaxi shale fractured by supercritical CO2. The results show that when the gas pressure is 1–3 MPa, the permeability decreases significantly with the increase in gas pressure, and the Klinkenberg effects plays a predominant role at this stage. When the gas pressure is 3–5 MPa, the permeability increases with the increase in gas pressure, and the influence of effective stress on permeability is dominant. The permeability decreases exponentially with the increase in effective stress. The permeability of shale after the adsorption of CO2 gas is significantly lower than that of before adsorption; the permeability decreases with the increase in temperature at 305.15 K–321.15 K, and with the increase in temperature, the permeability sensitivity to the temperature decreases. The permeability is closely related to supercritical CO2 injection pressure and volume stress; when the injection pressure of supercritical CO2 is constant, the permeability decreases with the increase in volume stress. The results can be used for the dynamic prediction of reservoir permeability and gas extraction in CO2-enhanced shale gas development.
Online modeling method for composite load model including EVs and battery storage based on measurement data
Authors: Yin Yanhe , Zhong Yi , He Yi , Li Guohao , Li Zhuohuan , Pan Shixian
Published: May 2024

Load models have a significant influence on power system simulation. However, current load modeling approaches can hardly satisfy the diversity and time-varying characteristics of loads [including electric vehicles (EVs) and battery storage] in terms of model accuracy and computing efficiency. An online modeling method for composite load models based on measurement information is proposed in this paper. Firstly, the dominant factors in load model output are analyzed based on the active subspace of parameter space. Then the clustering algorithm is applied to cluster the large number of underlying loads based on the characteristics of load daily output curves. Finally, the underlying loads are equivalently aggregated from the low voltage levels to the high voltage levels to construct the composite load model. Simulation results obtained based on PSCAD/EMTDC demonstrate that the load model constructed by the proposed approach can accurately reflect the actual load characteristics of a power system.
Ferroptosis and hepatocellular carcinoma: the emerging role of lncRNAs
Authors: Chen Haoran , Han Zhongyu , Su Junyan , Song Xuanliang , Ma Qingquan , Lin Yumeng , Ran Zijin , Li Xueping , Mou Rongkun , Wang Yi , Li Dongxuan
Published: May 2024

Hepatocellular carcinoma is the most common form of primary liver cancer and poses a significant challenge to the medical community because of its high mortality rate. In recent years, ferroptosis, a unique form of cell death, has garnered widespread attention. Ferroptosis, which is characterized by iron-dependent lipid peroxidation and mitochondrial alterations, is closely associated with the pathological processes of various diseases, including hepatocellular carcinoma. Long non-coding RNAs (lncRNAs), are a type of functional RNA, and play crucial regulatory roles in a variety of biological processes. In this manuscript, we review the regulatory roles of lncRNAs in the key aspects of ferroptosis, and summarize the research progress on ferroptosis-related lncRNAs in hepatocellular carcinoma.
Ocean surface radiation measurement best practices
Authors: Riihimaki Laura D. , Cronin Meghan F. , Acharya Raja , Anderson Nathan , Augustine John A. , Balmes Kelly A. , Berk Patrick , Bozzano Roberto , Bucholtz Anthony , Connell Kenneth J. , Cox Christopher J. , di Sarra Alcide G. , Edson James , Fairall C. W. , Farrar J. Thomas , Grissom Karen , Guerra Maria Teresa , Hormann Verena , Joseph K Jossia , Lanconelli Christian , Melin Frederic , Meloni Daniela , Ottaviani Matteo , Pensieri Sara , Ramesh K. , Rutan David , Samarinas Nikiforos , Smith Shawn R. , Swart Sebastiaan , Tandon Amit , Thompson Elizabeth J. , Venkatesan R. , Verma Raj Kumar , Vitale Vito , Watkins-Brandt Katie S. , Weller Robert A. , Zappa Christopher J. , Zhang Dongxiao
Published: May 2024

Ocean surface radiation measurement best practices have been developed as a first step to support the interoperability of radiation measurements across multiple ocean platforms and between land and ocean networks. This document describes the consensus by a working group of radiation measurement experts from land, ocean, and aircraft communities. The scope was limited to broadband shortwave (solar) and longwave (terrestrial infrared) surface irradiance measurements for quantification of the surface radiation budget. Best practices for spectral measurements for biological purposes like photosynthetically active radiation and ocean color are only mentioned briefly to motivate future interactions between the physical surface flux and biological radiation measurement communities. Topics discussed in these best practices include instrument selection, handling of sensors and installation, data quality monitoring, data processing, and calibration. It is recognized that platform and resource limitations may prohibit incorporating all best practices into all measurements and that spatial coverage is also an important motivator for expanding current networks. Thus, one of the key recommendations is to perform interoperability experiments that can help quantify the uncertainty of different practices and lay the groundwork for a multi-tiered global network with a mix of high-accuracy reference stations and lower-cost platforms and practices that can fill in spatial gaps.
The Drosophila blood–brain barrier invades the nervous system in a GPCR-dependent manner
Authors: Contreras Esteban G. , Kautzmann Steffen , Klämbt Christian
Published: May 2024

The blood–brain barrier (BBB) represents a crucial interface between the circulatory system and the brain. In Drosophila melanogaster, the BBB is composed of perineurial and subperineurial glial cells. The perineurial glial cells are small mitotically active cells forming the outermost layer of the nervous system and are engaged in nutrient uptake. The subperineurial glial cells form occluding septate junctions to prevent paracellular diffusion of macromolecules into the nervous system. To address whether the subperineurial glia just form a simple barrier or whether they establish specific contacts with both the perineurial glial cells and inner central nervous system (CNS) cells, we undertook a detailed morphological analysis. Using genetically encoded markers alongside with high-resolution laser scanning confocal microscopy and transmission electron microscopy, we identified thin cell processes extending into the perineurial layer and into the CNS cortex. Interestingly, long cell processes were observed reaching the glia ensheathing the neuropil of the central brain. GFP reconstitution experiments highlighted multiple regions of membrane contacts between subperineurial and ensheathing glia. Furthermore, we identify the G-protein-coupled receptor (GPCR) Moody as negative regulator of the growth of subperineurial cell processes. Loss of moody triggered a massive overgrowth of subperineurial cell processes into the CNS cortex and, moreover, affected the polarized localization of the xenobiotic transporter Mdr65. Finally, we found that GPCR signaling, but not septate junction formation, is responsible for controlling membrane overgrowth. Our findings support the notion that the Drosophila BBB is able to bridge the communication gap between circulation and synaptic regions of the brain by long cell processes.
P53/NANOG balance; the leading switch between poorly to well differentiated status in liver cancer cells
Authors: Ranjbar-Niavol Fazeleh , Rezaei Niloufar , Zhao Ying , Mirzaei Hamed , Hassan Moustapha , Vosough Massoud
Published: May 2024

Enforcing a well-differentiated state on cells requires tumor suppressor p53 activation as a key player in apoptosis induction and well differentiation. In addition, recent investigations showed a significant correlation between poorly differentiated status and higher expression of NANOG. Inducing the expression of NANOG and decreasing p53 level switch the status of liver cancer cells from well differentiated to poorly status. In this review, we highlighted p53 and NANOG cross-talk in hepatocellular carcinoma (HCC) which is regulated through mitophagy and makes it a novel molecular target to attenuate cancerous phenotype in the management of this tumor.
Impact of a DSS-supported medication review on the safety of drug therapy and quality of life in patients with antithrombotic therapy
Authors: Hassanzadeh Tanja Elnaz , Hohmann Carina , Culmsee Carsten
Published: May 2024

Polypharmacy is common among patients with antithrombotic medication, giving rise to concerns about Drug-Related Problems (DRPs). Therefore, these patients would benefit from a Medication Review (MR) along with pharmacist counselling to reduce the risks accompanying polymedication. This prospective study presents a concept for MRs that are applicable in German community pharmacies and can efficiently support pharmacist counselling and improve the safety of drug therapy. As this is a major challenge in everyday pharmacy practice, we used a Decision Support System (DSS) to evaluate its ability to support the process of pharmacist-led MRs. The primary endpoint was the impact of a community pharmacist on the reduction of DRPs. We investigated the impact of the interventions resulting from MRs on patients taking at least one antithrombotic drug as part of their polymedication regimen. Secondary endpoints were the reduction in the number of patients with bleeding risks and the improvement of patients’ Quality of Life (QoL) and therapy adherence. Furthermore, the DSS used in the study was controlled for correct data assessment and plausibility of data. We selected adult patients who were taking no less than three different medications for long-term treatment, at least one of which had to be an antithrombotic drug, and who were customers in one of eight selected pharmacies over a period of 6 months. Data from 87 patients were analyzed with DSS-support. A total of 234 DRPs were identified by the pharmacist (2.7 DRPs per patient). MR reduced DRPs by 43.2% which, resulting to a reduction of 1.2 DRPs per patient. The intervention also led to a significant improvement in the patients’ QoL (assessed via EQ-5D-5L questionnaire; p < 0.001) and enhanced therapy adherence (assessed via A14 questionnaire; p < 0.001). The control of correct data assessment (with 93.8% concordance) and plausibility of data (with 91.7% concordance) of the DSS software were conducted by an external auditor. No significant effect was found for overall bleeding risk. The results of this study indicate that DSS-supported and structured MR conducted by pharmacists can contribute to a reduction in DRPs and significantly improve patient’s QoL and adherence to treatment.
Skating techniques of ladies' world-class long-distance speed skaters to shorten curved-section time during the official 3,000 m race
Authors: Kimura Yuya , Yokozawa Toshiharu
Published: May 2024

This study aimed to identify the factors contributing to expedited passage through curved sections in skating by analyzing centripetal acceleration and skating motions during curving in a 3,000 m race for ladies' world-class speed skating. It included 14 elite skaters participating in the ladies' 3,000 m race held during the World Cup. The recorded area consisted of the first inner curve lane. Skaters were recorded as they passed through the measurement range at the initial, middle, and final stages of the race. Three synchronized high-speed cameras were used to record skaters from the front, back, and side. From the images obtained by the high-speed camera, 21 body endpoints and 4 blade edges were digitized at 50 Hz using specialized digitizing software. Three-dimensional coordinates of the 25 points were obtained using a panning direct linear transformation technique. The stroke-averaged centripetal acceleration and kinematic parameters were calculated based on the three-dimensional coordinates of the body during the curve-skating motion. Centripetal acceleration had a significant effect on the curved-section time in all three race stages (initial: F = 17.19, middle: F = 23.30, final: F = 16.64) and significantly decreased as the race progressed (left: F = 9.42, right: F = 8.05). Throughout the race, the right and left shanks and the body's center of mass (CM) during the stroke were raised (shank angle: left: F = 13.62, right: F = 11.02, CM height: left: F = 21.15, right: F = 21.69). The body-tilt angle for both strokes and shank-tilt angle for the right stroke were significantly correlated with centripetal acceleration in all race stages (body-tilt: left: initial: r = 0.80, middle: r = 0.75, final: r = 0.89, right: initial: r = 0.78, middle: r = 0.84, final: r = 0.67, right shank-tilt initial: r = 0.80, middle: r = 0.77, final: r = 0.63). These results suggested that to reduce the skating time through curved sections, maintaining an inward body tilt and minimizing the decrease in centripetal acceleration even in the final race stage are crucial considerations. They also suggested that when leaning the body inward and maintaining centripetal acceleration, the right shank should be leaned inward for the right stroke and the left shank should be leaned inward for the left stroke, or the left blade should be positioned farther to the right of the CM.
Constrained Parameterized Differential Dynamic Programming for Waypoint-Trajectory Optimization
Authors: Zheng Xiaobo , Xia Feiran , Lin Defu , Jin Tianyu , Su Wenshan , He Shaoming
Published: May 2024

Unmanned aerial vehicles (UAVs) are required to pass through multiple important waypoints as quickly as possible in courier delivery, enemy reconnaissance and other tasks to eventually reach the target position. There are two important problems to be solved in such tasks: constraining the trajectory to pass through intermediate waypoints and optimizing the flight time between these waypoints. A constrained parameterized differential dynamic programming (C-PDDP) algorithm is proposed for meeting multiple waypoint constraints and free-time constraints between waypoints to deal with these two issues. By considering the intermediate waypoint constraints as a kind of path state constraint, the penalty function method is adopted to constrain the trajectory to pass through the waypoints. For the free-time constraints, the flight times between waypoints are converted into time-invariant parameters and updated at the trajectory instants corresponding to the waypoints. The effectiveness of the proposed C-PDDP algorithm under waypoint constraints and free-time constraints is verified through numerical simulations of the UAV multi-point reconnaissance problem with five different waypoints. After comparing the proposed algorithm with fixed-time constrained DDP (C-DDP), it is found that C-PDDP can optimize the flight time of the trajectory with three segments to 7.35 s, 9.50 s and 6.71 s, respectively. In addition, the maximum error of the optimized trajectory waypoints of the C-PDDP algorithm is 1.06 m, which is much smaller than that (7 m) of the C-DDP algorithm used for comparison. A total of 500 Monte Carlo tests were simulated to demonstrate how the proposed algorithm remains robust to random initial guesses.
A Multisubstructure-Based Method for the Assessment of Displacement and Stress in a Fluid–Structure Interaction Framework
Authors: Xie Changchuan , Huang Kunhui , Meng Yang , Gao Nongyue , Zhang Zhitao
Published: May 2024

A multisubstructure-based method for assessing the deformation and stress of a fine-meshed model according to a coarse model was proposed. Integrating boundary conditions in a local fine-meshed model, a displacement mapping matrix from the coarse model to the fine-meshed model was constructed. The method was verified by a three-level panel in a fluid–structure interaction (FSI) framework by integrating the steady vortex lattice method (VLM). A comparison between the inner deformation distribution of the coarse model and that of the global fine-meshed model obtained from MSC.Nastran was carried out, and the results showed that the coarse model failed to demonstrate reliable strains and stresses. In contrast, the proposed method in this paper can effectively depict the inner deformation and critical stress distribution. The deformation error was lower than 8%, meeting engineering requirements. Moreover, the results of different working conditions can achieve a similar relative error of displacement for an identical position. The easy storage of the displacement mapping matrix and the convenience of the boundary information transformation among all substructure levels are prominent aspects. As a result, there is a solid foundation for addressing the time-dependent problem in spite of the simultaneity and region.
Design and Analysis of Low-Gravity Simulation Scheme for Mars Ascent Vehicle
Authors: Li Chen , Wang Huijuan , Hu Zhicheng , Wang Chen , Chen Jinbao
Published: May 2024

The sample carried back by the Mars Ascent Vehicle (MAV) is a potential flagship mission of deep space exploration in recent years. A low-gravity simulation experiment is an effective method and a necessary stage for verifying the performance of the MAV launch dynamic in Earth’s gravity. In this paper, the uniqueness of low-gravity simulation is illustrated by the classical pulley balance method for the high dynamic process of a test model of the MAV. Its movement direction is the same as the compensation force, which leads to the relaxation of the sling and the failure of the compensation force in traditional cable suspension. Here, three cable suspension schemes including an improved pulley balancing scheme based on a coordinate transformation scheme and based on a dynamic pulley group scheme are proposed. For the actual launch condition of the MAV, the motion state of the ascent under the schemes and the real Mars launch are compared, which proves the feasibility of the schemes. Among them, the improved pulley balancing scheme has the best gravity compensation effect, and the error between the average value and the required value is the smallest, only 1%.
Effect of Annealing Temperature on Microstructure and Properties of Solid Solution Extruded Mg–2.0Zn–1.0Y–0.5Zr Alloys
Authors: He Junguang , Cheng Zhenfei , Wen Jiuba , Tian Peiwu , Feng Wuyun , Zheng Xiangyang , Gong Yuan
Published: May 2024

In this investigation, the effects of different annealing temperatures (180, 200, 220, 240, 260, and 280 °C) on the microstructure evolution and properties of an extruded Mg–2.0Zn–1.0Y–0.5Zr (wt%) magnesium alloys were determined. Optical microscopy (OM), scanning electron microscopy (SEM), immersion corrosion, electrochemical corrosion experiments, and tensile testing were performed. Research has found that combining hot extrusion with subsequent low-temperature annealing significantly improves the strength, plasticity, and corrosion resistance of alloys due to grain refinement and a reduced dislocation density. The alloy was completely recrystallized at an annealing temperature of 240 °C for 4 h after solid solution extrusion, and the grains were fine and uniform, demonstrating the best comprehensive properties. Its corrosion rate, ultimate tensile strength, yield strength, and elongation were 0.454 ± 0.023 mm/y, 346.7 ± 8.9 MPa, 292.4 ± 6.9 MPa, and 19.0 ± 0.4%, respectively. The corrosion mechanism of the specimens under extruded and annealed conditions was analyzed. After annealing at 240 °C for 4 h, the dislocation and bimodal grain structure of the samples were almost eliminated, resulting in uniform and fine grains, which were conducive to the formation of a more uniform and denser oxide film, thus improving the corrosion resistance of the alloy.
Phytochemical Screening and Antibacterial Activity of Commercially Available Essential Oils Combinations with Conventional Antibiotics against Gram-Positive and Gram-Negative Bacteria
Authors: Neagu Răzvan , Popovici Violeta , Ionescu Lucia-Elena , Ordeanu Viorel , Biță Andrei , Popescu Diana Mihaela , Ozon Emma Adriana , Gîrd Cerasela Elena
Published: May 2024

The present study aims to evaluate the antibacterial activity of five commercially available essential oils (EOs), Lavender (LEO), Clove (CEO), Oregano (OEO), Eucalyptus (EEO), and Peppermint (PEO), against the most-known MDR Gram-positive and Gram-negative bacteria—Staphylococcus aureus (ATCC 25923), Escherichia coli (ATCC 25922), and Pseudomonas aeruginosa (ATCC 27853)—alone and in various combinations. Gas Chromatography–Mass Spectrometry (GC-MS) analysis established their complex compositions. Then, their antibacterial activity—expressed as the inhibition zone diameter (IZD) value (mm)—was investigated in vitro by the diffusimetric antibiogram method, using sterile cellulose discs with Ø 6 mm impregnated with 10 µL of sample and sterile borosilicate glass cylinders loaded with 100 µL; the minimum inhibitory concentration (MIC) value (µg/mL) for each EO was calculated from the IZD values (mm) measured after 24 h. The following EO combinations were evaluated: OEO+CEO, CEO+EEO, CEO+PEO, LEO+EEO, and EEO+PEO. Then, the influence of each dual combination on the activity of three conventional antibacterial drugs—Neomycin (NEO), Tetracycline (TET), and Bacitracin (BAC)—was investigated. The most active EOs against S. aureus and E. coli were LEO and OEO (IZD = 40 mm). They were followed by CEO and EEO (IZD = 20–27 mm); PEO exhibited the lowest antibacterial activity (IZD = 15–20 mm). EEO alone showed the highest inhibitory activity on P. aeruginosa (IZD = 25–35 mm). It was followed by CEO, LEO, and EEO (IZD = 7–11 mm), while PEO proved no antibacterial action against it (IZD = 0 mm). Only one synergic action was recorded (OEO+CEO against P. aeruginosa); EEO+PEO revealed partial synergism against S. aureus and CEO+PEO showed additive behavior against E. coli. Two triple associations with TET showed partial synergism against E. coli, and the other two (with NEO and TET) evidenced the same behavior against S. aureus; all contained EEO+PEO or CEO+PEO. Most combinations reported indifference. However, numerous cases involved antagonism between the constituents included in the double and triple combinations, and the EOs with the strongest antibacterial activities belonged to the highest antagonistic combinations. A consistent statistical analysis supported our results, showing that the EOs with moderate antibacterial activities could generate combinations with higher inhibitory effects based on synergistic or additive interactions.
Modelling Li-V2O5 Batteries Using Galvanostatic Intermittent Titration Technique and Electrochemical Impedance Spectroscopy: Towards Final Applications
Authors: Naranjo-Balseca Johanna , Martínez-Cisneros Cynthia , Várez Alejandro
Published: May 2024

Given the relevance of lithium and post-lithium batteries as electrochemical energy storage systems, the peculiar crystalline structure of V2O5 and its doping capacity play key roles in lithium-ion battery technology. To integrate them in high-efficiency modules, systematic methodologies are required to estimate the state of charge in a reliable way and predict the Li-V2O5 battery’s performance according to their electrochemical phenomena, including two plateaus in the galvanostatic cycling curves and the dynamic behavior governed by the energy demand. Most state of charge estimation and battery modeling procedures are focused on conventional Li-batteries that show a unique plateau. In this work, we propose a systematic methodology based on the galvanostatic intermittent titration technique and electrochemical impedance spectroscopy to study battery performance in the time and frequency domains, respectively. The proposed methodology, with a time–frequency correlation, promotes a deeper understanding of the electrochemical phenomena and general behavior of Li-V2O5 batteries, allowing for its subsequent extrapolation to more complex and higher-capacity lithium and post-lithium batteries used in high-power applications with a minimum error.
Alexander Friedenstein, Mesenchymal Stem Cells, Shifting Paradigms and Euphemisms
Authors: Phinney Donald G.
Published: May 2024

Six decades ago, Friedenstein and coworkers published a series of seminal papers identifying a cell population in bone marrow with osteogenic potential, now referred to as mesenchymal stem cells (MSCs). This work was also instrumental in establishing the identity of hematopoietic stem cell and the identification of skeletal stem/progenitor cell (SSPC) populations in various skeletal compartments. In recognition of the centenary year of Friedenstein’s birth, I review key aspects of his work and discuss the evolving concept of the MSC and its various euphemisms indorsed by changing paradigms in the field. I also discuss the recent emphasis on MSC stromal quality attributes and how emerging data demonstrating a mechanistic link between stromal and stem/progenitor functions bring renewed relevance to Friedenstein’s contributions and much needed unity to the field.
Gut Microbiome-Mediated Mechanisms in Alleviating Opioid Addiction with Aqueous Extract of Anacyclus pyrethrum
Authors: Baslam Abdelmounaim , Kabdy Hamid , Chait Yassine , Azraida Hajar , El Yazouli Loubna , Aboufatima Rachida , Chait Abderrahman , Baslam Marouane
Published: May 2024

The escalating rates of morbidity and mortality associated with opioid use disorder (OUD) have spurred a critical need for improved treatment outcomes. This study aimed to investigate the impact of prolonged exposure to Fentanyl, a potent opioid, on behavior, biochemical markers, oxidative stress, and the composition of the gut microbiome. Additionally, we sought to explore the therapeutic potential of Anacyclus pyrethrum in mitigating the adverse effects of Fentanyl withdrawal. The study unveiled that chronic Fentanyl administration induced a withdrawal syndrome characterized by elevated cortisol levels (12.09 mg/mL, compared to 6.3 mg/mL for the control group). This was accompanied by heightened anxiety, indicated by a reduction in time spent and entries made into the open arm in the Elevated Plus Maze Test, as well as depressive-like behaviors, manifested through increased immobility time in the Forced Swim Test. Additionally, Fentanyl exposure correlated with decreased gut microbiome density and diversity, coupled with heightened oxidative stress levels, evidenced by elevated malondialdehyde (MDA) and reduced levels of catalase (CAT) and superoxide dismutase (SOD). However, both post- and co-administration of A. pyrethrum exhibited substantial improvements in these adverse effects, effectively alleviating symptoms associated with OUD withdrawal syndrome and eliciting positive influences on gut microbiota. In conclusion, this research underscores the therapeutic potential of A. pyrethrum in managing Fentanyl withdrawal symptoms. The findings indicate promising effects in alleviating behavioral impairments, reducing stress, restoring gut microbiota, and mitigating oxidative stress, offering valuable insights for addressing the challenges of OUD treatment.
The Role of the Immune System in Pathobiology and Therapy of Myocarditis: A Review
Authors: Vicenzetto Cristina , Giordani Andrea , Menghi Caterina , Baritussio Anna , Peloso Cattini Maria , Pontara Elena , Bison Elisa , Rizzo Stefania , De Gaspari Monica , Basso Cristina , Thiene Gaetano , Iliceto Sabino , Marcolongo Renzo , Caforio Alida
Published: May 2024

The role of the immune system in myocarditis onset and progression involves a range of complex cellular and molecular pathways. Both innate and adaptive immunity contribute to myocarditis pathogenesis, regardless of its infectious or non-infectious nature and across different histological and clinical subtypes. The heterogeneity of myocarditis etiologies and molecular effectors is one of the determinants of its clinical variability, manifesting as a spectrum of disease phenotype and progression. This spectrum ranges from a fulminant presentation with spontaneous recovery to a slowly progressing, refractory heart failure with ventricular dysfunction, to arrhythmic storm and sudden cardiac death. In this review, we first examine the updated definition and classification of myocarditis at clinical, biomolecular and histopathological levels. We then discuss recent insights on the role of specific immune cell populations in myocarditis pathogenesis, with particular emphasis on established or potential therapeutic applications. Besides the well-known immunosuppressive agents, whose efficacy has been already demonstrated in human clinical trials, we discuss the immunomodulatory effects of other drugs commonly used in clinical practice for myocarditis management. The immunological complexity of myocarditis, while presenting a challenge to simplistic understanding, also represents an opportunity for the development of different therapeutic approaches with promising results.