bluuebunny/crossref_metadata_2025 huggingface dataset:
Dysplastic Progression to Adenocarcinoma is Equivalent in Ulcerative Colitis and Crohn’s Disease
Authors: Lightner Amy L , Vogler Sarah , McMichael John , Jia Xue , Regueiro Miguel , Qazi Taha , Steele Scott R
Published: June 2020

Background

We sought to determine the rate of progression from dysplasia to adenocarcinoma in ulcerative colitis [UC] vs Crohn’s diseases [CD] and describe the risk factors unique to each.

Methods

All adult patients [≥18 years] with a known diagnosis of either UC or CD who underwent a surveillance colonoscopy between January 1, 2010 and January 1, 2020 were included.

Results

A total of 23 751 surveillance colonoscopies were performed among 12 289 patients between January 1, 2010 and January 1, 2020; 6909 [56.2%] had a diagnosis of CD and 5380 [43.8%] had a diagnosis of UC. There were a total of 668 patients [5.4%] with low-grade dysplasia [LGD], 76 patients [0.62%] with high-grade dysplasia [HGD], and 68 patients [0.55%] with adenocarcinoma in the series; the majority of the dysplastic events were located in the right colon. Significantly more UC patients had a dysplastic event, but the rate of LGD and HGD dysplasia progression to adenocarcinoma was not significantly different in CD or UC [p = 0.682 and p = 1.0, respectively]. There was no significant difference in the rate of progression from LGD/HGD to adenocarcinoma based on random biopsies vs targeted biopsies of visible lesions [p = 0.37]. However, the rate of progression from LGD vs HGD to adenocarcinoma was significantly greater for HGD [p < 0.001].

Conclusion

While more UC patients were found to have neoplasia on colonoscopy, the rate of progression from LGD and HGD to adenocarcinoma was equivalent in UC and CD, suggesting that endoscopic surveillance strategies can remain consistent for all IBD patients.
Clinical Trials [and Tribulations]: The Immediate Effects of COVID-19 on IBD Clinical Research Activity in the UK
Authors: Noor Nurulamin M , Hart Ailsa L , Irving Peter M , Ghosh Subrata , Parkes Miles , Raine Tim
Published: June 2020

There have been immediate and profound impacts of SARS-CoV-2 and COVID-19 on health care services worldwide, with major consequences for non COVID-19 related health care. Alongside efforts to reconfigure services and enable continued delivery of safe clinical care for patients with IBD, consideration must also be given to management of IBD research activity. In many centres there has been an effective shutdown of IBD clinical trial activity as research sites have switched focus to either COVID-19 related research or clinical care only. As a result, the early termination of trial programmes, and loss of potentially effective therapeutic options for IBD, has become a real and worrying prospect. Moreover, in many countries research activity has become embedded into clinical care—with clinical trials often providing access to new therapies or strategies—which would otherwise not have been available in standard clinical pathways. This pandemic has significant implications for the design, conduct, analysis, and reporting of clinical trials in IBD. In this Viewpoint, we share our experiences from a clinical and academic perspective in the UK, highlighting the early challenges encountered, and consider implications for patients and staff at research sites, sponsors, research ethics committees, funders, and regulators. We also offer potential solutions both for now and for when we enter a recovery phase from the pandemic.
Adherence to prescribed medications in patients with heart failure: insights from liquid chromatography–tandem mass spectrometry-based urine analysis
Authors: Simpson Joanne , Jackson Colette E , Haig Caroline , Jhund Pardeep S , Tomaszewski Maciej , Gardner Roy S , Tsorlalis Yannis , Petrie Mark C , McMurray John J V , Squire Iain B , Gupta Pankaj
Published: June 2020

Aims

None of the existing studies on adherence have directly measured levels of all medications (or their metabolites) in patients with heart failure (HF).

Methods and results

We used liquid chromatography–tandem mass spectrometry to measure the presence of prescribed drugs (diuretics, angiotensin-converting enzyme inhibitors, angiotensin receptor blockers, beta-blockers, and mineralocorticoid receptor antagonists) in the urine of patients reviewed 4–6 weeks after hospitalization with HF. Patients were unaware that adherence was being assessed. Of the 341 patients studied, 281 (82.4%) were adherent, i.e. had all prescribed drugs of interest detectable in their urine. Conversely, 60 patients (17.6%) were partially or completely non-adherent. Notably, 24 of the 60 were non-adherent to only diuretic therapy and only seven out of all 341 patients studied (2.1%) were completely non-adherent to all prescribed HF drugs. There were no major differences in baseline characteristics between adherent and non-adherent patients.

Conclusion

Non-adherence, assessed using a single spot urine measurement of drug levels, was confirmed in one of five patients evaluated 4–6 weeks after hospitalization with HF.
Mid-term results of modified L-shaped incision technique for supracardiac total anomalous pulmonary venous connection
Authors: Feng Zicong , Yang Yang , He Fengpu , Pang Kunjing , Ma Kai , Zhang Sen , Qi Lei , Wang Guanxi , Mao Fengqun , Yuan Jianhui , Li Shoujun
Published: June 2020

OBJECTIVES

Surgical outcomes of supracardiac total anomalous pulmonary venous connection (TAPVC) repair by the posterior technique (PT) remain unsatisfactory. This study aimed to compare the outcomes of the modified L-shaped incision technique with the PT for supracardiac TAPVC repair.

METHODS

From January 2009 to December 2019, 121 consecutive patients with supracardiac TAPVC undergoing surgical repair in our institution were included (L-group, n = 53; PT group, n = 68). A propensity score-matched analysis was performed. Patients with single-ventricle physiology or atrial isomerism were excluded. All clinical data were retrospectively analysed.

RESULTS

In the unmatched cohort, the median follow-up duration was 33 months (interquartile range 26–65 months). There were 5 operative mortalities (4.1%) and 12 late mortalities (9.9%). Postoperative pulmonary venous obstruction (PVO) was documented in 21 patients. After matching (52 pairs), the overall survival rate in the L-group was 88.2% at both 3 and 5 years. For the propensity score-matched patients with preoperative PVO (n = 20), statistically significant differences (P = 0.002) were found by Kaplan–Meier curves with freedom from death and postoperative PVO at 1 and 3 years of 100% and 85.7% [standard deviation (SD): 13.2%] in the L-group and 90% (SD: 9.5%) and 22.9% (SD: 14.1%) in the PT group, respectively. Multivariable analysis revealed that the use of the PT was an independent risk factor for death and postoperative PVO (hazard ratio 4.12, 95% confidence interval 1.12–15.16; P = 0.03).

CONCLUSIONS

The modified L-shaped incision technique provided an acceptable outcome for supracardiac TAPVC repair. Compared with PT, the modified L-shaped incision technique was significantly associated with decreased death and postoperative PVO in patients with obstructed supracardiac TAPVC.
Without coal in the age of steam and dams in the age of electricity: an explanation for the failure of Portugal to industrialize before the Second World War
Authors: Henriques Sofia Teives , Sharp Paul
Published: June 2020

We provide a natural resource explanation for the divergence of the Portuguese economy relative to other European countries before the Second World War. First, we demonstrate that a lack of domestic resources meant that Portugal experienced limited and unbalanced growth during the age of steam. Imports of coal were prohibitively expensive for inland areas. Coastal areas industrialized through steam but were constrained by limited demand from the interior. Second, we show that after the First World War, when other coal-poor countries turned to hydro-power, Portugal relied on coal-based thermal-power, creating a vicious circle of high-energy prices and labor-intensive industrialization.
Does the Impact of Intensive Lifestyle Intervention on Cardiovascular Disease Risk Vary According to Frailty as Measured via Deficit Accumulation?
Authors: Simpson Felicia R , Pajewski Nicholas M , Beavers Kristen M , Kritchevsky Stephen , McCaffery Jeanne , Nicklas Barbara J , Wing Rena R , Bertoni Alain , Ingram Frank , Ojeranti Daniel , Espeland Mark A
Published: June 2020

Background

Individuals are often counseled to use behavioral weight loss strategies to reduce risk for cardiovascular disease (CVD). We examined whether any benefits for CVD risk from weight loss intervention extend uniformly to individuals across a range of underlying health states.

Methods

The time until first occurrence of a composite of fatal and nonfatal myocardial infarction and stroke, hospitalized angina, or CVD death was analyzed from 8 to 11 years of follow-up of 4,859 adults who were overweight or obese, aged 45–76 years with Type 2 diabetes. Individuals had been randomly assigned to either an intensive lifestyle intervention (ILI) or diabetes support and education (DSE). Participants were grouped by intervention assignment and a frailty index (FI) based on deficit accumulation, ordered from fewer (first tertile) to more (third tertile) deficits.

Results

Baseline FI scores were unrelated to intervention-induced weight losses and increased physical activity. The relative effectiveness of ILI on CVD incidence was inversely related to baseline FI in a graded fashion (p = .01), with relative benefit (hazard ratio = 0.73 [95% CI 0.55,0.98]) for individuals in the first FI tertile to no benefit (hazard ratio = 1.15 [0.94,1.42]) among those in the third FI tertile. This graded relationship was not seen for individuals ordered by age tertile (p = .52), and was stronger among participants aged 45–59 years (three-way interaction p = .04).

Conclusions

In overweight/obese adults with diabetes, multidomain lifestyle interventions may be most effective in reducing CVD if administered before individuals have accrued many age-related health deficits. However, these exploratory analyses require confirmation by other studies.

Clinical Trial Registration

NCT00017953
Lithospheric stress, strain and displacement changes from GRACE-FO time-variable gravity: case study for Sar-e-Pol Zahab Earthquake 2018
Authors: Eshagh Mehdi , Fatolazadeh Farzam , Tenzer Robert
Published: June 2020

Temporal variations in the Earth's gravity field can be used for monitoring of lithospheric deformations. The network of continuously operating gravity stations is required for this purpose but a global coverage by such network is currently extremely sparse. Temporal variations in long-wavelength part of the Earth's gravity field have been, however, observed by two satellite missions, namely the Gravity Recovery And Climate Experiment (GRACE) and the GRACE Follow-On (GRACE-FO). These satellite gravity observations can be used to study long-wavelength deformations of the lithosphere. Consequently, considering the lithosphere as a spherical elastic shell and solving the partial differential equation of elasticity for it, the stress, strain and displacement inside the lithosphere can be estimated. The lower boundary of this shell is assumed to be stressed by mantle convection, which has a direct relation to the Earth's gravity field according to Runcorn's theory. Changes in gravity field lead to changes in the sublithospheric stress and the stress propagated throughout the lithosphere. In this study, we develop mathematical models in spherical coordinates for describing the stress propagation from the sublithosphere through the lithosphere. We then organize a system of observation equations for finding a special solution to the boundary-value problem of elasticity in the way that provides a stable solution. In contrast, models presented in previously published studies are ill-posed. Furthermore, we use constants of the solution determined from the boundary stresses to determine the strain and displacements leading to these stresses, while in previous studies only the stress has been considered according to rheological properties of the lithosphere. We demonstrate a practical applicability of this theoretical model to estimate the stress–strain redistribution caused by the Sar-e-Pol Zahab 2018 earthquake in Iran by using the GRACE-FO monthly solutions.
Systematic investigation of the skin inChst14−/−mice: A model for skin fragility in musculocontractural Ehlers–Danlos syndrome caused byCHST14variants (mcEDS-CHST14)
Authors: Hirose Takuya , Mizumoto Shuji , Hashimoto Ayana , Takahashi Yuki , Yoshizawa Takahiro , Nitahara-Kasahara Yuko , Takahashi Naoki , Nakayama Jun , Takehana Kazushige , Okada Takashi , Nomura Yoshihiro , Yamada Shuhei , Kosho Tomoki , Watanabe Takafumi
Published: June 2020

Loss-of-function variants in CHST14 cause a dermatan 4-O-sulfotransferase deficiency named musculocontractural Ehlers–Danlos syndrome-CHST14 (mcEDS-CHST14), resulting in complete depletion of the dermatan sulfate moiety of decorin glycosaminoglycan (GAG) chains, which is replaced by chondroitin sulfate. Recently, we uncovered structural alteration of GAG chains in the skin of patients with mcEDS-CHST14. Here, we conducted the first systematic investigation of Chst14 gene-deleted homozygote (Chst14−/−) mice. We used skin samples of wild-type (Chst14+/+) and Chst14−/− mice. Mechanical fragility of the skin was measured with a tensile test. Pathology was observed using light microscopy, decorin immunohistochemistry and electron microscopy (EM) including cupromeronic blue (CB) staining. Quantification of chondroitin sulfate and dermatan sulfate was performed using enzymatic digestion followed by anion-exchange HPLC. In Chst14−/− mice, skin tensile strength was significantly decreased compared with that in Chst14+/+ mice. EM showed that collagen fibrils were oriented in various directions to form disorganized collagen fibers in the reticular layer. Through EM-based CB staining, rod-shaped linear GAG chains were found to be attached at one end to collagen fibrils and protruded outside of the fibrils, in contrast to them being round and wrapping the collagen fibrils in Chst14+/+ mice. A very low level of dermatan sulfate disaccharides was detected in the skin of Chst14−/− mice by anion-exchange chromatography. Chst14−/− mice, exhibiting similar abnormalities in the GAG structure of decorin and collagen networks in the skin, could be a reasonable model for skin fragility of patients with mcEDS-CHST14, shedding light on the role of dermatan sulfate in maintaining skin strength.
Nonlinear generalization of the monotone single index model
Authors: Kereta Željko , Klock Timo , Naumova Valeriya
Published: June 2020

Single index model is a powerful yet simple model, widely used in statistics, machine learning and other scientific fields. It models the regression function as $g(\left <{a},{x}\right>)$, where $a$ is an unknown index vector and $x$ are the features. This paper deals with a nonlinear generalization of this framework to allow for a regressor that uses multiple index vectors, adapting to local changes in the responses. To do so, we exploit the conditional distribution over function-driven partitions and use linear regression to locally estimate index vectors. We then regress by applying a k-nearest neighbor-type estimator that uses a localized proxy of the geodesic metric. We present theoretical guarantees for estimation of local index vectors and out-of-sample prediction and demonstrate the performance of our method with experiments on synthetic and real-world data sets, comparing it with state-of-the-art methods.
Surveillance of HIV-1 transmitted integrase strand transfer inhibitor resistance in the UK
Authors: Mbisa Jean L , Ledesma Juan , Kirwan Peter , Bibby David F , Manso Carmen , Skingsley Andrew , Murphy Gary , Brown Alison , Dunn David T , Delpech Valerie , Geretti Anna Maria
Published: June 2020

Background

HIV treatment guidelines have traditionally recommended that all HIV-positive individuals are tested for evidence of drug resistance prior to starting ART. Testing for resistance to reverse transcriptase inhibitors and PIs is well established in routine care. However, testing for integrase strand transfer inhibitor (InSTI) resistance is less consistent.

Objectives

To inform treatment guidelines by determining the prevalence of InSTI resistance in a national cohort of recently infected individuals.

Patients and methods

Recent (within 4 months) HIV-1 infections were identified using a Recent Infection Testing Algorithm of new HIV-1 diagnoses in the UK. Resistance-associated mutations (RAMs) in integrase, protease and reverse transcriptase were detected by ultradeep sequencing, which allows for the sensitive estimation of the frequency of each resistant variant in a sample.

Results

The analysis included 655 randomly selected individuals (median age = 33 years, 95% male, 83% MSM, 78% white) sampled in the period 2014 to 2016 and determined to have a recent infection. These comprised 320, 138 and 197 samples from 2014, 2015 and 2016, respectively. None of the samples had major InSTI RAMs occurring at high variant frequency (≥20%). A subset (25/640, 3.9%) had major InSTI RAMs occurring only as low-frequency variants (2%–20%). In contrast, 47/588 (8.0%) had major reverse transcriptase inhibitor and PI RAMs at high frequency.

Conclusions

Between 2014 and 2016, major InSTI RAMs were uncommon in adults with recent HIV-1 infection, only occurring as low-frequency variants of doubtful clinical significance. Continued surveillance of newly diagnosed patients for evidence of transmitted InSTI resistance is recommended to inform clinical practice.
Technical note: fluorescein as an indicator of enteric mucosal barrier function in preruminant lambs
Authors: Duff Audrey F , Bielke Lisa R , Relling Alejandro E
Published: June 2020

Increased intestinal permeability can be observed during the physiologic stress response and has been linked to suppression of animal health and performance. Previously published data have shown the efficacy of fluorescein isothiocyanate dextran (FITC-d; 4.17 mg/kg) as a marker of enteric inflammation and mucosal barrier function in multiple species. Fluorescein is a smaller, less expensive alternative molecule possessing similar properties. The following two experiments compared FITC-d and fluorescein as potential indicators of intestinal permeability in pre- and postweaned lambs administered daily intramuscular injections of dexamethasone (Dex; 0.1 mg/kg) for 1 wk. Experiment 1 consisted of five preweaned lambs that were placed in one of two treatment groups: fluorescein with Dex (F+Dex) or fluorescein only (F). On day 7, blood was collected before and 1 h after oral administration of fluorescein (50 mg/kg). Experiment 2 included 12 weaned lambs and four treatment groups: F+Dex, F, FITC-d with Dex (Fd+Dex), and FITC-d only (Fd). On day 7, blood was collected before and 2 h after oral administration of FITC-d (4.17 mg/kg) or fluorescein (50 mg/kg). Plasma fluorescence was reported as the ratio between T1h/T0 or T2h/T0 for experiment 1 or 2, respectively. Experiment 1 showed a significant increase in T1h/T0 ratio of F+Dex relative to F lambs (P = 0.05) indicative of increased leaky gut; however, no differences (P = 0.22) were obtained in experiment 2. Results of these experiments suggest fluorescein may serve as a suitable marker of enteric permeability in preruminant lambs, but not in those with functional rumens.
A new source of high-protein distillers dried grains with solubles (DDGS) has greater digestibility of amino acids and energy, but less digestibility of phosphorus, than de-oiled DDGS when fed to growing pigs
Authors: Cristobal Minoy , Acosta Jessica P , Lee Su A , Stein Hans H
Published: June 2020

AbstractThree experiments were conducted to test the hypothesis that standardized ileal digestibility (SID) of amino acids (AA), concentration of metabolizable (ME), and standardized total tract digestibility (STTD) of P in a new source of distillers dried grains with solubles (DDGS; ProCap DDGS) are greater than in conventional de-oiled DDGS. In experiment 1, nine barrows (initial BW: 67.2 ± 6.4 kg) with a T-cannula in the distal ileum were allotted to a triplicated 3 × 3 Latin square design with three diets and three periods for a total of nine replicate pigs per diet. Two diets included ProCap DDGS or de-oiled DDGS as the sole source of crude protein (CP) and AA. An N-free diet was used to determine the basal endogenous losses of CP and AA. Ileal digesta were collected on days 5 and 6 of each period after 4 d of adaptation to diets. Results from experiment 1 indicated that ProCap DDGS contained more CP and AA compared with de-oiled DDGS. The SID of all AA in ProCap DDGS was greater (P < 0.001) compared with de-oiled DDGS with the exception that the SID of Pro was not different between the two sources of DDGS. In experiment 2, 24 growing barrows (initial BW: 32.7 ± 3.1 kg) were housed individually in metabolism crates and used in a randomized complete block design and fed a corn-based diet or two diets containing corn and each source of DDGS with eight replicate pigs per diet. Fecal and urine samples were collected for 4 d after 7 d of adaptation. Results from experiment 2 indicated that concentration of ME in ProCap DDGS was greater (P < 0.05) compared with corn or de-oiled DDGS. In experiment 3, 32 growing barrows (initial BW: 20.2 ± 0.9 kg) were placed in metabolism crates and allotted to four diets with eight pigs per diet using a 2 × 2 factorial treatment arrangement. The de-oiled DDGS and ProCap DDGS were both included in a diet without microbial phytase and a diet with microbial phytase (500 units/kg diet). Pigs were adapted to the diets for 5 d and fecal samples were collected for 4 d. Results from experiment 3 indicated that inclusion of phytase in the diet containing ProCap DDGS increased (P < 0.05) the STTD of P, but addition of phytase to the de-oiled DDGS diet did not increase STTD of P (interaction, P < 0.001), but the STTD of P was greater (P < 0.05) in de-oiled DDGS compared with ProCap DDGS. In conclusion, ProCap DDGS has greater SID of AA and contains more ME, but has reduced STTD of P compared with conventional de-oiled DDGS.
Pollinator-dependent evolution of floral trait combinations in an orchid herb
Authors: Wu Yun , Duan Xu-Yu , Xiang Yong , Weng Shao-Bin , Zhong Jin-Yu , Li Jing , Li Qing-Jun
Published: June 2020

Aims

As one of the most important agents driving floral evolution, pollinators shape the diversity of flowers in angiosperms. However, most previous studies have only quantified pollinators driving the evolution of a single floral trait, and experimental estimates of the potential role of pollinators in shaping the evolution of floral trait associations are relatively rare.

Methods

We experimentally identified and estimated the pollinator-mediated directional and correlational selection on single floral traits and trait combinations across 2 years in an orchid species, Spiranthes sinensis.

Important Findings

Pollinators mediated directional selection for an earlier flowering start date and larger corolla size. Pollinators mediated positive correlational selection on the combinations of floral display traits and negative correlational selection on the combinations of flowering phenology and floral display traits. In addition, the strength of selection differed over time. Our results highlight the potential role of pollinators in driving the evolution of floral trait combinations and suggest that it is necessary to consider floral character functional associations when seeking to understand and predict the evolutionary trajectory of flowers in angiosperms.
TB1: from domestication gene to tool for many trades
Authors: Igartua Ernesto , Contreras-Moreira Bruno , Casas Ana M
Published: June 2020

This article comments on:

Dixon LE, Pasquariello M, Boden SA. 2020. TEOSINTE BRANCHED1 regulates height and stem internode length in bread wheat. Journal of Experimental Botany 71, 4742–4750.
EPIC simulations of Neptune’s dark spots using an active cloud microphysical model
Authors: Hadland Nathan , Sankar Ramanakumar , LeBeau Raymond Paul , Palotai Csaba
Published: June 2020

The Great Dark Spot (GDS-89) observed by Voyager 2 was the first of several large-scale vortices observed on Neptune, the most recent of which was observed in 2018 in the Northern hemisphere (NDS-2018). Ongoing observations of these features are constraining cloud formation, drift, shape oscillations, and other dynamic properties. In order to effectively model these characteristics, an explicit calculation of methane cloud microphysics is needed. Using an updated version of the Explicit Planetary Isentropic Coordinate General Circulation Model (EPIC GCM) and its active cloud microphysics module to account for the condensation of methane, we investigate the evolution of large-scale vortices on Neptune. We model the effect of methane deep abundance and cloud formation on vortex stability and dynamics. In our simulations, the vortex shows a sharp contrast in methane vapour density inside compared to outside the vortex. Methane vapour column density is analogous to optical depth and provides a more consistent tracer to track the vortex, so we use that variable over potential vorticity. We match the meridional drift rate of the GDS and gain an initial insight into the evolution of vortices in the Northern hemisphere, such as the NDS-2018.
Ionized gas in the NGC 5253 supernebula: high spatial and spectral resolution observations with the JVLA and TEXES
Authors: Beck Sara C , Lacy John , Turner Jean , Baobab Liu Hauyu , Greathouse Thomas , Consiglio S M , Ho Paul T P
Published: June 2020

The youngest, closest, and most compact embedded massive star cluster known excites the supernebula in the nearby dwarf galaxy NGC 5253. It is a crucial target and test case for studying the birth and evolution of the most massive star clusters. We present observations of the ionized gas in this source with high spatial and spectral resolution. The data include continuum images of free–free emission with ≈0.15 arcsec resolution made with the Karl G. Jansky Very Large Array (JVLA) at 15, 22, and 33 GHz, and a full data cube of the [S iv] 10.5 μm  fine-structure emission line with ≈4.5 km s−1 velocity resolution and 0.3 arcsec beam, obtained with the Texas Echelon Cross Echelle Spectrograph (TEXES) on Gemini North. We find that (1) the ionized gas extends out from the cluster in arms or jets, and (2) the ionized gas comprises two components offset both spatially and in velocity. We discuss mechanisms that may have created the observed velocity field; possibilities include large-scale jets or a subcluster falling on to the main source.
Exploding the Realism-Antirealism Debate: Putnam contra Putnam
Authors: Macarthur David
Published: June 2020

Putnam is famous (or infamous) for often changing his allegiance between various forms of realism and antirealism. In this paper I want to use Putnam’s own reflections and insights on the realism-antirealism issue to provide a powerful case for skepticism about the entire debate—in spite of the fact that that is not Putnam’s own ultimate attitude. From this skeptical perspective, I shall argue that Putnam has helped us see that the realism-antirealism debate faces a dilemma: either it resolves into existence questions about particular items that are resolvable by, say, scientific or mathematical or ethical etc. practices rather than by appeal to philosophical argument; or it represents a misguided response to skepticism about an entire class or realm of items (e.g., the unobservable items posited by physics, or the manifest world of tables and chairs) given that it hopelessly attempts to answer skepticism on the skeptic’s own terms. What Putnam tends to overlook in his realist moments is that we can philosophically undermine skepticism without being committed to any philosophically substantial realism or antirealism.
The initial impact of COVID-19 and policy responses on household incomes
Authors: Brewer Mike , Gardiner Laura
Published: June 2020

As soon as the scale of the coronavirus shock to the economy became clear, the UK government introduced three policies to protect directly household incomes: a Job Retention Scheme, to pay the wages of employees who were temporarily furloughed; a Self-Employment Income Support Scheme, to give grants to established self-employed people whose businesses had been affected; and a package of increases to entitlements to social security benefits, with Universal Credit at the core, that bolstered the UK’s means-tested ‘safety net’. This paper analyses the design and beneficiaries of these policies and, given the distributional pattern of the labour market shock, considers the emerging overall impact on living standards, particularly of low-income households.
Blurred and Confused: The Paradox of Police in Schools
Authors: Montes Andrea N , Mears Daniel P , Collier Nicole L , Pesta George B , Siennick Sonja E , Brown Samantha J
Published: June 2020

The get-tough era in juvenile justice ushered in significant changes to how schools respond to delinquency. One of the most visible changes has been the increasing presence of police officers who work in and patrol schools. The purpose of this article is to argue that this practice has blurred the boundaries between schools and police and, in turn, has created confusion about the roles of educators in safety efforts and of officers in education efforts, respectively. We draw on prior literature about school safety, school discipline, and law enforcement officers in school environments to describe this confusion and its consequences. This article contributes to literature aimed at understanding the changing landscape of policing and school safety and the challenges as well as opportunities facing the police and schools in educating youth, responding to misbehaviour, and maintaining safe school environments.
EFFECT OF BUILDUP FACTORS ON INDOOR GAMMA DOSE RATE
Authors: Manić V , Manić G , Nikezić D , Krstić D
Published: June 2020

The effect of buildup factors on absorbed dose rate in air and the effective dose from gamma rays of primordial radionuclides in building materials, was investigated in the article. Specific absorbed dose rates were calculated for the standard concrete room, as well as, for rooms where brick and covering building materials were used. For all room models the Harima (G-P) buildup factors were applied, while for the standard room the Berger’s and Taylor’s buildup factors were used, too. The contribution of the radiation buildup to absorbed dose rate and effective dose was determined as large as 41%.
Prejudice drives exogenous attention to outgroups
Authors: Giménez-Fernández Tamara , Kessel Dominique , Fernández-Folgueiras Uxía , Fondevila Sabela , Méndez-Bértolo Constantino , Aceves Nayamin , García-Rubio María José , Carretié Luis
Published: June 2020

Exogenous attention allows the automatic detection of relevant stimuli and the reorientation of our current focus of attention towards them. Faces from an ethnic outgroup tend to capture exogenous attention to a greater extent than faces from an ethnic ingroup. We explored whether prejudice toward the outgroup, rather than lack of familiarity, is driving this effect. Participants (N = 76) performed a digit categorization task while distractor faces were presented. Faces belonged to (i) a prejudiced outgroup, (ii) a non-prejudiced outgroup and (iii) their ingroup. Half of the faces were previously habituated in order to increase their familiarity. Reaction times, accuracy and event-related potentials (ERPs) were recorded to index exogenous attention to distractor faces. Additionally, different indexes of explicit and implicit prejudice were measured, the latter being significantly greater towards prejudiced outgroup. N170 amplitude was greater to prejudiced outgroup—regardless of their habituation status—than to both non-prejudiced outgroup and ingroup faces and was associated with implicit prejudice measures. No effects were observed at the behavioral level. Our results show that implicit prejudice, rather than familiarity, is under the observed attention-related N170 effects and that this ERP component may be more sensitive to prejudice than behavioral measures under certain circumstances.
Effects of 27 mo of rotational vs. continuous grazing on horse and pasture condition
Authors: Williams Carey A , Kenny Laura B , Weinert Jennifer R , Sullivan Kevin , Meyer William , Robson Mark G
Published: June 2020

The objective of this study was to determine whether rotational grazing generates horse, pasture, or cost benefits over continuous grazing. The study established two replicates (1.57 ha each) of rotational (R; four grazing sections and a stress lot per replicate, where horses were fed a moderate quality grass hay at 2% of body weight when not grazing) and continuous (C) grazing systems (treatments). Twelve Standardbred mares were grazed for an overall stocking rate of 0.52 ha/horse (n = 3 in each pasture). Recommended management practices for each grazing system were followed for 27 mo including three grazing seasons. Samples were collected monthly between 0800 and 1000. Results were analyzed in SAS (V9.4) using mixed model repeated-measures analysis of covariance, chi-square tests of association, and two-sample t-tests. Alpha level was set at P < 0.05. The C horses were maintained on pasture for 100% of the study duration (844 d; August 1, 2014 to November 22, 2016), while R horses had access to pasture for approximately half of this time (408 ± 33 d). The average length of grazing bout per rotational grazing section during the grazing season increased numerically each year from 7.88 ± 0.76 d in 2014, 10.0 ± 0.61 d in 2015, and 10.9 ± 0.80 d in 2016. Average horse body condition score (BCS) and body fat differed by treatment, with C horses (BCS 6.3 ± 0.05, 17.9 ± 0.15% body fat) greater than R horses (BCS 5.9 ± 0.05, 16.8 ± 0.15% body fat). Both sward height and herbage mass were greater in R (11.8 ± 0.1 cm tall; 1,513 ± 41 kg/ha) than C pastures (6.9 ± 0.1 cm tall; 781 ± 35 kg/ha). The R pastures had higher proportions of vegetative and total cover, planted grasses (tall fescue and orchardgrass), and weeds but lower proportions of grass weeds (nonplanted grasses) and other (rocks, litter, bare ground, etc.) as compared with C pastures. Digestible energy, acid detergent fiber, and calcium were higher in R vs. C pastures; however, crude protein was lower in R vs. C pastures. There were no significant differences between treatments for average monthly amount of hay fed (C, 597 ± 34.1 vs. R, 659 ± 34.1 kg) or average monthly pasture maintenance cost (C, $17.55 ± 3.14 vs. R, $20.50 ± 3.14). This study is one of few replicated experiments comparing the effects of rotational and continuous grazing for horses on pasture quality, horse condition, and production costs. The results here support the recommendation of rotational grazing for production, environmental, and ecological purposes.
β-Blockers and angiotensin-converting enzyme inhibitors with sublingual immunotherapy: are risks related to individual product safety profile?
Authors: Smith Derek M. , Coop Christopher A. , Freeman Theodore M.
Published: June 2020

Purpose of review

The objective of this article is to review the available literature regarding the risks associated with sublingual immunotherapy and angiotensin-converting enzyme (ACE) inhibitors or β-blocker use. It also evaluates for any differences in these risks among the available sublingual immunotherapy (SLIT) tablets.

Recent findings

A literature search was conducted in PubMed to identify peer-reviewed articles using the following keywords: anaphylaxis, ACE inhibitor, β-blocker, and sublingual immunotherapy. Minimal data exist regarding their safety of SLIT in patients concomitantly taking ACE inhibitors or β-blockers. The adverse reaction rates seem similar between SLIT products.

A risk-versus-benefit discussion should be communicated with the patient taking a β-blocker before beginning SLIT but automatic denial of SLIT to these patients is not warranted.
Wandering by Children with Autism Spectrum Disorders: Impact of Electronic Tracking Devices on Elopement Behavior and Quality of Life
Authors: McLaughlin Laura , Rapoport Eli , Keim Sarah A. , Adesman Andrew
Published: June 2020

Objective:

Half of US children with autism spectrum disorder (ASD) have attempted to elope from adult supervision at least once, elevating their risk for serious injury/death. This study aimed to assess, in a sample of children with ASD aged 4 to 18 years who had previously wandered, whether electronic tracking device (ETD) use is associated with changes in the elopement behavior and household quality of life (QOL).

Methods:

An anonymous, online questionnaire assessing elopement interventions, elopement behavior, household QOL, attitudes toward ETDs, and sociodemographics was distributed via US autism-related organizations to caregivers of children with ASD. Differences in retrospective estimates of elopement behavior and household QOL before ETD use and during ETD use were evaluated using Wilcoxon signed-rank tests.

Results:

A total of 2563 participants completed the questionnaire; 1459 participants met the inclusion criteria. For the current (n = 361) and past (n = 96) ETD users, ETD use was associated with decreased frequency and duration of elopement and decreased risk for serious injury because of elopement (all p < 0.001). ETD use was similarly associated with improvements across all 5 measures of QOL. Among the past ETD users, reasons for discontinuation included device discomfort/fit (33.3%), burden of use (27.1%), and financial cost (14.6%). Among the non-ETD users (n = 1002), common barriers to ETD use were cost (47.5%) and lack of awareness of ETD technology (18.8%).

Conclusion:

Electronic tracking devices represent a promising technology to help safeguard the well-being of children with ASD while reducing the emotional toll that elopement imposes on families. Cost concerns, burden of use, and lack of awareness seem to limit the widespread adoption of ETDs.
Exposure to Parental Depressive Symptoms: A Longitudinal Analysis on the Association with Adolescents' Depressive Symptoms and Adjustment Problems
Authors: Donado Carolina , Friedrich Yvonne , Kossowsky Joe , Locher Cosima , Koechlin Helen
Published: June 2020

Objective:

Parental depressive symptoms have been associated with depressive symptoms and adjustment problems in adolescents. However, longitudinal studies assessing both mothers' and fathers' depressive symptoms over time and their association with adolescents' outcomes are sparse.

Methods:

Data were obtained from the Study of Early Child Care and Youth Development. A total of 1364 children and families were followed from the child's birth until the age of 15 years. Adolescents' depressive symptoms were evaluated via self-reported questionnaire at ages 11 to 15 years. Adjustment problems at 15 years of age were defined as high internalizing and/or externalizing problems. Parental depressive symptoms were assessed several times during the study period. Trajectories created using partitional clustering analyses were entered in logistic regression models to predict adolescents' outcomes.

Results:

After adjusting for sociodemographic variables, adolescents' outcomes were associated with every additional time point of reported maternal (depressive symptoms: odds ratio [OR] = 1.2, p = 0.001; adjustment problems: OR = 1.1, p = 0.003) and paternal depressive symptoms (adjustment problems: OR = 1.2, p = 0.027). When maternal and paternal depressive symptom trajectories were combined, we found adolescents' depressive symptoms to be significantly associated with mother elevated and stable subclinical father scores (OR = 3.3, p = 0.003) and girls (OR = 5.4, p < 0.001). Adjustment problems were associated with father elevated and stable subclinical mother (OR = 1.9, p = 0.003) and mother elevated and stable subclinical father (OR = 2.1, p = 0.001) trajectories.

Conclusion:

Parental depressive symptoms are an important risk factor for adolescents' outcomes. This highlights the importance of continuously evaluating parents' mental status across child development. The cumulative effect of recurrent depressive symptoms and the combined parental trajectories are especially predictive for the development of adolescents' outcomes.
Atypical polypoid adenomyoma follow-up and management
Authors: Biasioli Anna , Londero Ambrogio P. , Orsaria Maria , Scrimin Federica , Mangino Francesco Paolo , Bertozzi Serena , Mariuzzi Laura , Cagnacci Angelo
Published: June 2020

Background:

Atypical polypoid adenomyoma (APA) is a rare uterine tumor typically found in fertile age and associated with infertility. Among young nullipara women, conservative treatment is proposed despite the high recurrence rate and the association with endometrial cancer.

Our aim was to assess the risk of recurrence with different conservative treatments in fertile ages and the prevalence of malignant or pre-malignant associated lesions to better address an adequate patient counselling when treatment modalities are discussed.

Methods:

This study is a systematic review and meta-analysis of case reports and case series about APA management and follow-up. A literature search was carried from Medline and Scopus for studies published from January 1, 1980 to December 31, 2018.

Results:

We included 46 observational studies and 296 cases in fertile women. The prevalence of APA relapse was 44% (CI.95 33–57%) and was lower in cases treated with operative hysteroscopy (22%; CI.95 11–39%) than in cases treated with blind curettage and polypectomy (38%; CI.95 15–67%). The prevalence of the concomitant or during the follow-up diagnosis of endometrial carcinoma was 16% (CI.95 9–29%). The risk of cancer development during follow-up was significantly less in cases treated with histeroscopy (10.56% new cumulative diagnosis at 5 years follow up; CI.95 0–23.7%) than blind curettage and polypectomy (35.5% new cumulative diagnosis at 5 years; CI.95 11.65–52.92%; P < .05). Medical treatment with medroxyprogesterone acetate after surgery does not reduce APA recurrence. Pregnancy was observed in 79% cases in which the desire was expressed.

Conclusion:

This review suggests that conservative treatment performed by operative hysteroscopy is the optimal choice because it lowers the risk of recurrence, improves the accuracy of concomitant carcinoma or hyperplasia diagnosis, and leaves the possibility of future pregnancies.
Efficacy of measuring the invasive diameter of lung adenocarcinoma using mediastinal window settings
Authors: Uchida Tsuyoshi , Matsubara Hirochika , Onuki Yuichiro , Matsuoka Hiroyasu , Ichihara Tomofumi , Nakajima Hiroyuki
Published: June 2020

The recently published 8th edition of the tumor node and metastasis Classification of Lung Cancer proposes using the maximum dimension of the solid component of a ground glass nodule (GGN) for the T categorization. However, few studies have investigated the collection of this information when using mediastinal window settings. In this study, we evaluated tumor measurement data obtained from computed tomography (CT) scans when using mediastinal window settings.

This study included 202 selected patients with persistent, partly solid GGNs detected on thin-slice CT after surgical treatment between 2004 and 2013. We compared the differences in tumor diameters measured by 2 different radiologists using a repeated-measures analysis of variance. We divided the patients into 2 groups based on the clinical T stage (T1a+T1b vs T1c) and estimated the probability of overall survival (OS) and disease-free survival (DFS) using Kaplan–Meier curves.

The study included 94 male and 108 female patients. The inter-reviewer differences between tumor diameters were significantly smaller when the consolidation to maximum tumor diameter ratio was ≤0.5. The 2 clinical groups classified by clinical T stage differed significantly with respect to DFS when using the mediastinal window settings. However, no significant differences in OS or DFS were observed when using the lung window setting.

Our study yielded 2 major findings. First, the diameters of GGNs could be measured more accurately using the mediastinal window setting. Second, measurements obtained using the mediastinal window setting more clearly depicted the effect of clinical T stage on DFS.
Efficacy of Shenmai injection for the treatment of chronic heart failure
Authors: Gao Peng , Wu Xian , Zhang Fu-hua , Qiao Zhi-li , Yang Li-jie
Published: June 2020

Background:

This study will assess the efficacy and safety of Shenmai injection (SMI) for the treatment of chronic heart failure (CHF).

Methods:

The following electronic bibliographic databases will be searched from inception to the March 25, 2020 without language and publication time limitations: MEDLINE, PUBMED, Cochrane Library, Web of Science, Scopus, WANGFANG, Chinese Biomedical Literature Database, and China National Knowledge Infrastructure. All randomized controlled trials related to the SMI for patients with CHF will be included. All study selection, data extraction, and study quality will be carried out by 2 reviewers. Any disagreements will be solved by a third reviewer through discussion. RevMan 5.3 software will be used for data synthesis and data analysis.

Results:

This study will summarize the present evidence of SMI for the treatment of patients with CHF.

Conclusion:

The findings of this study will determine whether SMI is effective and safety for the treatment of CHF or not.

Study registration number:

INPLASY202050029.
Activity of regorafenib in advanced pretreated soft tissue sarcoma
Authors: Marrari Andrea , Bertuzzi Alexia , Bozzarelli Silvia , Gennaro Nicolò , Giordano Laura , Quagliuolo Vittorio , De Sanctis Rita , Sala Simona , Balzarini Luca , Santoro Armando
Published: June 2020

Background:

Regorafenib, a multitargeted tyrosine kinase inhibitor, proved to be active in patients with soft tissue sarcomas (STS).

Methods:

We conducted an open-label, non-randomized, single-center phase II study in advanced pretreated STS patients. Patients received regorafenib 160 mg daily on days 1 enrule 21 of a 28-day cycle. The primary endpoint was the progression-free survival (PFS) at 8 weeks. Toxicity was registered.

Results:

Between April 2015 and November 2016, 21 patients were enrolled in the trial. A total of 13 out of 21 evaluable patients (61.9%) were progression-free at 8 weeks. Median PFS was 3.8 months (95% CI: 2.1–9.4). Median overall survival was 14.8 months (95% CI: 7.7–27.8). In the intention-to-treat population, we reported a PFS of 66.7% at 3 months (95% CI: 40.4–83.4) and 16.7% at 12 months (95% CI: 4.1–36.5). As per the RECIST criteria, the response rate was 4.7% (1 partial response out of 21 evaluable patients) with a clinical benefit rate of 61.9%; no complete response was observed. Treatment was well tolerated.

Conclusion:

Regorafenib shows signs of clinical activity in patients with advanced STS.

Clinical Trial Registration:

ClinicalTrials.gov NCT02307500.