bluuebunny/crossref_metadata_2025 huggingface dataset:
Metataxonomic Analysis of the Uterine Microbiota Associated with Low Fertility in Dairy Cows Using Endometrial Tissues Prior to First Artificial Insemination
Authors: Yagisawa Takuya , Uchiyama Jumpei , Takemura-Uchiyama Iyo , Ando Shun , Ichii Osamu , Murakami Hironobu , Matsushita Osamu , Katagiri Seiji
Published: April 2023

We examined the uterine microbiota associated with low fertility in dairy cows derived from four commercial farms via a metataxonomic approach using endometrial tissues prior to the first artificial insemination. The present study provided two new insights into the relevance of uterine microbiota with respect to fertility.
First-Day-of-Life Rectal Swabs Fail To Represent Meconial Microbiota Composition and Underestimate the Presence of Antibiotic Resistance Genes
Authors: Graspeuntner S. , Lupatsii M. , Dashdorj L. , Rody A. , Rupp J. , Bossung V. , Härtel C.
Published: April 2023

Currently, there are numerous suggestions on how to ease the notoriously complex and error-prone methodological setups to study the gut microbiota of newborns during the first days of life. Especially, meconium samples are regularly failing to yield meaningful data output and therefore have been suggested to be replaced by rectal swabs as done in adults as well.
Oklahoma’s coordinated response to more than a decade of elevated seismicity
Authors: Murray* Kyle E. , Brooks Colin , Walter Jacob I. , Ogwari Paul O.
Published: April 2023

In the period between 1961 and 2008, Oklahoma, USA, averaged about two M ≥3.0 earthquakes per year, with no damage to any built infrastructure. A substantial increase in seismic activity was first observed in 2009, when there were 20 M ≥3.0 earthquakes, and activity peaked in 2015, when over 900 M ≥3.0 earthquakes occurred. Because of the unprecedented increase in seismic activity, the governor’s office of Oklahoma formed a Coordinating Council of researchers, regulators, industry, and other stakeholders in 2015. The Coordinating Council was led by the Secretary of Energy and Environment and charged with understanding and attempting to mitigate (that is, reduce, if not eliminate) induced seismicity and potential impacts. Major outcomes of the coordinated efforts included delineation of an area of interest (AOI) for seismicity in Oklahoma, modifications to underground injection control (UIC) well completion depths and injection rates into UIC wells in the AOI, development of the Oklahoma Well and Seismic Monitoring (OWSM) application used for regulatory oversight and action, modified well completion protocols, a more robust seismic network, and numerous scientific investigations and publications.

Because of concerted efforts between regulators and industry, disposal into the Arbuckle Group, the primary zone for wastewater disposal, in the AOI was reduced by more than 50% though oil production continued to increase. Seismic activity decreased over a 6 yr period with 619, 302, 195, 65, 39, and 29 M ≥3.0 earthquakes occurring in 2016, 2017, 2018, 2019, 2020, and 2021, respectively. At the time of latest updates to this chapter (16 October 2022), there have been 12 M ≥3.0 earthquakes and one M ≥4.0 earthquake, so the projected total of M ≥3.0 earthquakes in 2022 is 17. Using these metrics, the coordinated efforts of Oklahoma stakeholders appear to have successfully reduced seismicity with respect to frequency and number in the range of minor but often felt (M 3.0–3.9), light (M 4.0–4.9), and moderate (M 5.0–5.9) earthquakes. So, the Oklahoma case provides examples of how stakeholder action diminished seismic hazards and how similar actions could be used to reduce induced seismicity in other areas where injections occur.
Effect of Different Factors on Predicting Constants of Acidity of Low-Molecular Organic Compounds by Means of Machine Learning
Authors: Matyushin D. D. , Sholokhova A. Yu. , Buryak A. K.
Published: April 2023

A study is performed of the effect the way of standardizing the molecular structure and parameters of calculating molecular fingerprints has on the accuracy of predicting constants of acidity. It is shown that standardization (i.e., the choice of the tautomeric form and the way of writing the structure of the molecule) using OpenEye QuacPac gives the best results, but the RDKit library allows comparable accuracy to be achieved. It is established that how the charge state is chosen has a great effect on the accuracy of predictions. The accuracy of predictions depending on the radius (size of substructures) of circular molecular fingerprints is studied, and the best results are achieved using radius r = 2. A random forest, a machine learning algorithm, is used. It is also shown that the use of support vectors ensures fairly high accuracy when optimizing hyperparameters.
Socioemotional and behavioural difficulties in children with chronic physical conditions: analysis of the Longitudinal Study of Australian Children
Authors: David-Wilathgamuwa Shaun , Hu Nan , Meyers Tammy , O'Loughlin Rachel , Lingam Raghu
Published: April 2023

Objectives

To examine the prevalence of socioemotional and behavioural difficulties (SEBDs) in children with chronic physical conditions (CPCs) and to analyse how this prevalence varied with the type and number of CPCs and the age of the child.

Design

Cross-sectional study of a secondary data analysis of the Longitudinal Study of Australian Children.

Setting

An Australian nationally representative sample of general population of children.

Participants

15 610 children-waves aged 6–14 years.

Intervention/exposure

Children reported to have at least 1 of the 21 CPCs by their parents.

Main outcome measures

Clinically relevant SEBDs were defined using standardised cut-offs of the parent-administered Strengths and Difficulties Questionnaire.

Results

Children with a CPC have significantly increased odds of total, internalising and externalising SEBDs than those without (total SEBDs, adjusted odds rartio or OR 3.13, 95% CI 2.52 to 3.89), controlling for sex, age, socioeconomic status and parental mental health status. The highest prevalence of total SEBDs was found in children with chronic fatigue (43.8%), epilepsy (33.8%) and day wetting (31.6%). An increasing number of comorbid CPCs was associated with a rising prevalence of SEBDs. On average, 24.2% of children with at least four CPCs had SEBDs. These children had 8.83-fold increased odds (95% CI 6.9 to 11.31) of total SEBDs compared with children without a CPC. Age was positively related to the odds of SEBDs.

Conclusion

Children with a CPC have a significantly increased risk of having SEBDs than those without. These findings highlight the need for routine assessment and integrated intervention for SEBDs among children with CPCs.
Long-term association between neighbourhood socioeconomic deprivation in early childhood and perceived stress in early adulthood: a multilevel cohort study
Authors: Jakobsen Andreas Lindegaard
Published: April 2023

Background

Previous studies have shown that neighbourhood socioeconomic deprivation is related to mental health problems, with chronic stress responses as one possible biopsychological pathway; however, less is known about the possible long-term effects of neighbourhood deprivation throughout the life course. The aim of this study was to examine the association between neighbourhood socioeconomic deprivation in early childhood and perceived stress in early adulthood.

Methods

Data from the, Danish National Health Survey 2017 in which Cohen’s 10-item Perceived Stress Scale was measured (range 0–40) were used to follow a cohort consisting of all survey respondents aged 20–24 years born between 1992 and 1996. The respondents were linked to Danish register data, including data on the parent(s) with whom the respondents lived, to measure family-level socioeconomic characteristics, parental mental health problems and neighbourhood socioeconomic deprivation at age 3 for each respondent. Furthermore, the respondents were linked to georeferenced neighbourhoods. Linear mixed models were used to estimate the association between neighbourhood socioeconomic deprivation at age 3 and perceived stress at age 20–24.

Results

A 1 SD increase in neighbourhood socioeconomic deprivation in early childhood was associated with a 0.59-point increase in perceived stress in early adulthood (95% CI 0.41 to 0.77). The association was attenuated but remained statistically significant after controlling for individual and family characteristics and neighbourhood socioeconomic deprivation in early adulthood (coef 0.26, 95% CI 0.06 to 0.46).

Conclusion

The findings suggest that children growing up in more socioeconomically deprived neighbourhoods may be prone to higher levels of perceived stress later in life.
Gödel-type solutions within the f(R, Q, P) gravity
Authors: Nascimento J. R. , Petrov A. Yu. , Porfírio P. J. , Silva Ramires N. da
Published: April 2023

In this work, we scrutinize the consistency of spacetime homogeneous Gödel-type metrics within f(R, Q, P) theories of gravity for well-motivated matter sources. As it is well known, such geometries allow for causality violation. We provide general conditions to engender completely causal solutions in a manner completely different from general relativity. We take some specific models, for instance, $$f(R,Q,P)=R -\dfrac{\mu ^{4n+2}}{\left( a R^2+b Q+c P\right) ^n}$$

f

(
R
,
Q
,
P
)

=
R
-

μ

4
n
+
2

a

R
2

+
b
Q
+
c
P

n

, to illustrate the general results. Notably, we also find an unusual completely causal vacuum solution in the presence of a non-trivial cosmological constant which corresponds to the case $$m^2=4\omega ^2$$

m
2

=
4

ω
2

.
INVESTIGATIONS ON MECHANICAL, WEAR AND MACHINING BEHAVIOR OF TITANIUM-REINFORCED AlMg0.5Si COMPOSITES
Authors: SRINIVASAN S. , THIRUMURUGAVEERAKUMAR S.
Published: April 2023

AlMg0.5Si (AA6063) as a base matrix composite with different weight percentages of Titanium (Ti) has been synthesized by the stir casting method. Objective of this research is to investigate the effect of Ti addition on AA6063 to produce aluminium matrix composites (AMCs). AA6063, AA6063/4%-Ti, AA6063/8%-Ti, and AA6063/12%-Ti are different volume fractions. The Scanning electron microscope (SEM) analysis is used to examine the modified grain refinement and worn surface on fabricated AMCs. The evenly distributed structure was attained on the processed AA6063/Ti combinations. The mechanical properties of processed composites were investigated with the following experimental tests such as tensile strength, impact strength, micro hardness, compressive, and flexural strength. The entire mechanical properties of fabricated AMCs were enhanced with increasing Ti reinforcement particles. The CNC drilling of AA6063/Ti composites was machined by spindle speed, feed and depth of cut. The gray relational analysis (GRA) was used to carry out the optimal machining parameters with their responses such as material removal rate and surface roughness. From the analysis of ANOVA, spindle speed parameter achieved most influencing parameters.
Understanding the Interaction between Local Government Guidance Funds and the Local Rule of Law in China’s Central–Local Relation Paradigm
Authors: ZHU HAN , SHEN WEI
Published: April 2023

The central–local structure is a unique perspective for both China’s constitutional law and party-state structure. However, the conventional approach to this issue pays great attention to its structural framework. This paper takes a unique approach to the functionality of local government guidance funds, an increasingly frequently used method for local governments to implement national projects like Made in China 2025. The project has been one of the several controversies between the United States and China in their ongoing trade confrontation. Built upon an analysis of paradigms in central–local relations, this paper further investigates the rule of law movement at the level of local government, an often ignored and under-discussed aspect of China’s central–local structure. The tentative conclusion is that the use of local government guidance funds facilitates local competition and promotes the rule of law.
Influence of Inter-Molar Concentration of Cu and Zn on the Various Properties of Sprayed Nanocrystalline Cu2ZnSnS4 Thin Films
Authors: Chandel Tarun , Sharma Ranjana , Kumar Ashwani , Prasher Dixit
Published: April 2023

In this work, the quaternary nanostructured Cu2ZnSnS4 (CZTS) thin films were deposited on ITO glass substrates at a temperature of 300[Formula: see text]C by spray pyrolysis method and the influence of inter-molar concentration variations of copper and zinc on the structural, morphological and optical properties of grown samples was studied. The films were characterized by different sophisticated techniques including X-ray diffractometer (XRD), scanning electron microscopy (SEM), Raman spectroscopy and UV–Vis spectroscopy. The solitary presence of kesterite tetragonal phase with favored orientation along (112) plane is confirmed by XRD patterns and Raman spectroscopy. However, due to the variation in lattice parameters, a moderate shifting in (hkl) planes was observed. SEM micrographs and EDAX analysis showed the uniform morphology of the so-grown CZTS films covered with nanoplates of different sizes and the ionic compositional variation of the precursor solution matches with the elemental variation in the grown samples. A minor nonstoichiometry in chemical composition ratio [Formula: see text] from 0.74 to 1.24 was noticed in the films. Optical studies of CZTS films showed that these films possess optical band gap ranging from 1.45[Formula: see text]eV to 1.60[Formula: see text]eV.
Multi-Agent Semi-Siamese Training for Long-Tail and Shallow Face Learning
Authors: Tai Yichun , Shi Hailin , Zeng Dan , Du Hang , Hu Yibo , Zhang Zicheng , Zhang Zhijiang , Mei Tao
Published: April 2023

With the recent development of deep convolutional neural networks and large-scale datasets, deep face recognition has made remarkable progress and been widely used in various applications. However, unlike the existing public face datasets, in many real-world scenarios of face recognition, the depth of the training dataset is shallow, which means that only two face images are available for each ID. With the non-uniform increase of samples, such issue is converted to a more general case, known as long-tail face learning, which suffers from data imbalance and intra-class diversity dearth simultaneously. These adverse conditions damage the training and result in the decline of model performance. Based on Semi-Siamese Training, we introduce an advanced solution, namedMulti-Agent Semi-Siamese Training(MASST), to address these problems. MASST includes a probe network and multiple gallery agents—the former aims to encode the probe features, and the latter constitutes a stack of networks that encode the prototypes (gallery features). For each training iteration, the gallery network, which is sequentially rotated from the stack, and the probe network form a pair of Semi-Siamese networks. We give the theoretical and empirical analysis that, given the long-tail (or shallow) data and training loss, MASST smooths the loss landscape and satisfies the Lipschitz continuity with the help of multiple agents and the updating gallery queue. The proposed method is out of extra-dependency, and thus can be easily integrated with the existing loss functions and network architectures. It is worth noting that although multiple gallery agents are employed for training, only the probe network is needed for inference, without increasing the inference cost. Extensive experiments and comparisons demonstrate the advantages of MASST for long-tail and shallow face learning.
Rubisco Function, Evolution, and Engineering
Authors: Prywes Noam , Phillips Naiya R. , Tuck Owen T. , Valentin-Alvarado Luis E. , Savage David F.
Published: April 2023

Carbon fixation is the process by which CO2 is converted from a gas into biomass. The Calvin–Benson–Bassham cycle (CBB) is the dominant carbon-consuming pathway on Earth, driving >99.5% of the ∼120 billion tons of carbon that are converted to sugar by plants, algae, and cyanobacteria. The carboxylase enzyme in the CBB, ribulose-1,5-bisphosphate carboxylase/oxygenase (rubisco), fixes one CO2 molecule per turn of the cycle into bioavailable sugars. Despite being critical to the assimilation of carbon, rubisco's kinetic rate is not very fast, limiting flux through the pathway. This bottleneck presents a paradox: Why has rubisco not evolved to be a better catalyst? Many hypothesize that the catalytic mechanism of rubisco is subject to one or more trade-offs and that rubisco variants have been optimized for their native physiological environment. Here, we review the evolution and biochemistry of rubisco through the lens of structure and mechanism in order to understand what trade-offs limit its improvement. We also review the many attempts to improve rubisco itself and thereby promote plant growth.
Hinge Joints Performance Assessment of a PC Hollow Slab Bridge Based on Impact Vibration Testing
Authors: Xia Qi , Zhou Yi-chen , Cheng Yu-yao , Zhang Jian
Published: April 2023

Hinge joint performance during the operation of prefabricated prestressed concrete (PC) hollow slab bridges is critical to ensure their lateral collaborative working condition and safe serviceability. Traditional performance identification of hinge joints mainly relies on manual inspection, which is inefficient and inaccurate. At the same time, existing indexes (such as acceleration and strain) can only qualitatively detect the damage to hinge joints. This study proposes a novelty detection method based on impact vibration testing to rapidly perform the quantitative assessment of the working condition of the hinge joints. The relationship between hinge joint performance and lateral load distribution (LLD) is first derived in detail by theoretical analysis. And then, the quantitative analysis of collaborative performance is converted to the identification of the LLD influence line, which is innovatively established by the lateral flexibility of the hollow slab bridge. The effectiveness of the proposed method is verified through a multibeam model using ABAQUS software, and the lateral collaborative working relationship between slabs is simulated using the connector elements. Furthermore, the LLD influence lines and hinge joints performance of a PC hollow slab Yanhu Bridge are evaluated based on the impact vibration testing with sensor lateral arrangement strategy. The detection results show that the proposed method can quickly and accurately identify the damage location and the stiffness loss of hinge joints.
Computing a Many-to-Many Matching with Demands and Capacities between Two Sets Using the Hungarian Algorithm
Authors: Rajabi-Alni Fatemeh , Bagheri Alireza
Published: April 2023

A many-to-many matching (MM) between two sets matches each element of one set to at least one element of the other set. A general case of the MM is the many-to-many matching with demands and capacities (MMDC) satisfying given lower and upper bounds on the number of elements matched to each element. In this article, we give a polynomial-time algorithm for finding a minimum-cost MMDC between two sets using the well-known Hungarian algorithm.
The Effect of Erythritol Injection in Decreasing of Abortion Rate in Local Breed Ewes
Authors: Owain Maher Saber , Hasan Mustafa Salah , Atiyah Ali Ghazi
Published: April 2023

This study designed to evaluate the effect of Erythritol injection in decreasing of abortion rate in local breed ewes. Fifty pregnant ewes from local breed aged 2–4 years with a history of abortion except G1, were fed ad libitum hay and grains with water. The study was carried out in Salah Aldein province at special farm at a period of July–November 2022. These animals were tests for brucella by using rose Bengal and ELISA at zero day for confirmation; these animals were divided into 5 groups: G1 was brucella −ve and pregnant at 60 days, G2 was brucella +ve and pregnant at 60 days, G3 brucella+ve pregnant animals and treated by antibiotics gentamicin 10%, 3 ml/animal for 3 days, G4 brucella +ve and pregnant and giving erythritol, 10 ml S/C of 10% solution (solve in water and glycerol), and G5 was brucella +ve, and all pregnant and giving Erythritol+ gentamycin 10%, 3 ml/animal for 3 days. The experiment takes 12 weeks. Blood was withdrawn at different times of experiment (0, 2 weeks and end of experiment). The seroprevalence of brucellosis was shown that all animals at G4 and G5 where seropositive after 14 days of experiment, at end of pregnancy the seropositivity were highly significantly in G4 and G5 as compared with another groups. The current results showed that percentages of abortion were higher in G2, followed by G3, while it has been reduced significantly in G4 and G1. In conclusion, Erythritol alone can decrease the rate of abortion by making the bacteria extracellular far from placenta and evading of infection by immunity and/or gentamicin injection. Also, erythritol can be used as elicit diagnosis of brucellosis in latent infected animals.
Electrical Double-Layer Capacitor Based on Low Aqueous Electrolyte Contents in EmimTFO Ionic Liquid
Authors: Kitenge V. N. , Tarimo D. J. , Oyedotun K. O. , Rutavi G. , Bakhoum D. T. , Manyala N.
Published: April 2023

A study has been conducted on the electrochemical properties of 1-ethyl-3-methylimidazolium trifluoromethanesulfonate (EmimTFO) protic ionic liquid enhanced by adding potassium nitrate (2.5 M) aqueous solution. The properties of EmimTFO as well as mixtures diluted by molar fractions of 0.6, 0.7, 0.8, and 0.9 of KNO3 were also investigated through measurements of viscosity, density, and conductivity. In a three-electrode test run at 0.25 A g-1, the addition of 2.5 M KNO3 solution generated peak specific capacities of ~40.2 and ~85.8 mAh g-1 on the positive and negative potentials, respectively. These performances surpassed the specific capacities obtained for EmimTFO in a three-electrode run at 0.25 A g-1 using the same electrode material (activated carbon). The top-performing electrolyte mixture ([EmimTFO]0.8[2.5 M KNO3]0.2) was then used to assemble a symmetric supercapacitor, which could run at a voltage of ~2.1 V. The device was able to retain 71.35% of its capacitance after 10,000 cycles of charge and discharge. It also displayed higher specific energy and power of 22.21 Wh kg-1 and 520 W kg-1, respectively, at 0.5 A g-1 as compared to specific energies of 4.73 Wh kg-1 and 11.2 Wh kg-1 for the devices assembled with single EmimTFO and 2.5 M KNO3 as the electrolytes, respectively.
SAIFC: A Secure Authentication Scheme for IOV Based on Fog-Cloud Federation
Authors: Salami Yashar , Khajehvand Vahid , Zeinali Esmaeil
Published: April 2023

The Internet of Things allows vehicles to communicate with their surroundings and send various traffic and road conditions to other vehicles, making driving better. Data received from other vehicles sometimes need to be processed. In this state, the data should be sent to the Roadside unit for processing and fog if necessary. The source and destination must know each other’s identities to send and receive information, and various attacks can threaten source and destination authentication. The paper presents secure authentication scheme based on fog-cloud for the Internet of Vehicles. Formal and informal security analyses verify that the SAIFC demonstrates resistance to famous attacks. The SAIFC is compared with another scheme regarding security features, computing, and communication costs. The SAIFC simulated with the NS3 tool and compared several routing protocols in packet loss, packet delivery, end-to-end delay, throughput, and MAC/PHY overhead.
Proteomic Profiling of Extracellular Matrix Components from Patient Metastases Identifies Consistently Elevated Proteins for Developing Nanobodies That Target Primary Tumors and Metastases
Authors: Jailkhani Noor , Clauser Karl R. , Mak Howard H. , Rickelt Steffen , Tian Chenxi , Whittaker Charles A. , Tanabe Kenneth K. , Purdy Stephen R. , Carr Steven A. , Hynes Richard O.
Published: April 2023

Metastases are hard to detect and treat, and they cause most cancer-related deaths. The relative lack of therapies targeting metastases represents a major unmet clinical need. The extracellular matrix (ECM) forms a major component of the tumor microenvironment in both primary and metastatic tumors, and certain ECM proteins can be selectively and abundantly expressed in tumors. Nanobodies against ECM proteins that show selective abundance in metastases have the potential to be used as vehicles for delivery of imaging and therapeutic cargoes. Here, we describe a strategy to develop phage-display libraries of nanobodies against ECM proteins expressed in human metastases, using entire ECM-enriched preparations from triple-negative breast cancer (TNBC) and colorectal cancer metastases to different organs as immunogens. In parallel, LC-MS/MS-based proteomics were used to define a metastasis-associated ECM signature shared by metastases from TNBC and colorectal cancer, and this conserved set of ECM proteins was selectively elevated in other tumors. As proof of concept, selective and high-affinity nanobodies were isolated against an example protein from this signature, tenascin-C (TNC), known to be abundant in many tumor types and to play a role in metastasis. TNC was abundantly expressed in patient metastases and widely expressed across diverse metastatic sites originating from several primary tumor types. Immuno-PET/CT showed that anti-TNC nanobodies bind TNBC tumors and metastases with excellent specificity. We propose that such generic nanobodies against tumors and metastases are promising cancer-agnostic tools for delivery of therapeutics to tumor and metastatic ECM.

Significance:

Nanobodies specific for extracellular matrix markers commonly expressed in primary tumors and metastases are promising agents for noninvasive detection of tumors and metastases and potential tools for targeted therapy.
Table S2 from Eganelisib, a First-in-Class PI3Kγ Inhibitor, in Patients with Advanced Solid Tumors: Results of the Phase 1/1b MARIO-1 Trial
Authors: Hong David S. , Postow Michael , Chmielowski Bartosz , Sullivan Ryan , Patnaik Amita , Cohen Ezra E.W. , Shapiro Geoffrey , Steuer Conor , Gutierrez Martin , Yeckes-Rodin Heather , Ilaria Robert , O'Connell Brenda , Peng Joanna , Peng Guangbin , Zizlsperger Nora , Tolcher Anthony , Wolchok Jedd D.
Published: April 2023

Summary of anti-tumor activity endpoints in patients treated with eganelisib monotherapy and combination therapy
Censoring rules 3 from Eganelisib, a First-in-Class PI3Kγ Inhibitor, in Patients with Advanced Solid Tumors: Results of the Phase 1/1b MARIO-1 Trial
Authors: Hong David S. , Postow Michael , Chmielowski Bartosz , Sullivan Ryan , Patnaik Amita , Cohen Ezra E.W. , Shapiro Geoffrey , Steuer Conor , Gutierrez Martin , Yeckes-Rodin Heather , Ilaria Robert , O'Connell Brenda , Peng Joanna , Peng Guangbin , Zizlsperger Nora , Tolcher Anthony , Wolchok Jedd D.
Published: April 2023

Study IPI-549-01 progression-free survival censoring rules for efficacy analyses
Supplementary Figure S3 from Comprehensive Genome Profiling in Patients With Metastatic Non–Small Cell Lung Cancer: The Precision Medicine Phase II Randomized SAFIR02-Lung/IFCT 1301 Trial
Authors: Barlesi Fabrice , Tomasini Pascale , Karimi Maryam , Michiels Stefan , Raimbourg Judith , Daniel Catherine , Janicot Henri , Madroszyk Anne , Audigier-Valette Clarisse , Quoix Elisabeth , Mazieres Julien , Moro-Sibilot Denis , Dansin Eric , Molinier Olivier , Morel Hugues , Pichon Eric , Cortot Alexis , Otto Josiane , Chomy François , Souquet Pierre-Jean , Cloarec Nicolas , Giroux-Leprieur Etienne , Bieche Ivan , Lacroix Ludovic , Boyault Sandrine , Attignon Valery , Soubeyran Isabelle , Morel Alain , Tran-Dien Alicia , Jacquet Alexandra , Dall'Olio Filippo Gustavo , Jimenez Marta , Soria Jean-Charles , Besse Benjamin
Published: April 2023

Supplementary Figure 3. Forest plot with subgroup analysis for OS in substudy 1.
Supplementary Figure S1 from Comprehensive Genome Profiling in Patients With Metastatic Non–Small Cell Lung Cancer: The Precision Medicine Phase II Randomized SAFIR02-Lung/IFCT 1301 Trial
Authors: Barlesi Fabrice , Tomasini Pascale , Karimi Maryam , Michiels Stefan , Raimbourg Judith , Daniel Catherine , Janicot Henri , Madroszyk Anne , Audigier-Valette Clarisse , Quoix Elisabeth , Mazieres Julien , Moro-Sibilot Denis , Dansin Eric , Molinier Olivier , Morel Hugues , Pichon Eric , Cortot Alexis , Otto Josiane , Chomy François , Souquet Pierre-Jean , Cloarec Nicolas , Giroux-Leprieur Etienne , Bieche Ivan , Lacroix Ludovic , Boyault Sandrine , Attignon Valery , Soubeyran Isabelle , Morel Alain , Tran-Dien Alicia , Jacquet Alexandra , Dall'Olio Filippo Gustavo , Jimenez Marta , Soria Jean-Charles , Besse Benjamin
Published: April 2023

Supplementary Figure 1. Planned exploratory analyses by study drug for selumetinib, vistusertib and capivasertib.
Study Protocol from Comprehensive Genome Profiling in Patients With Metastatic Non–Small Cell Lung Cancer: The Precision Medicine Phase II Randomized SAFIR02-Lung/IFCT 1301 Trial
Authors: Barlesi Fabrice , Tomasini Pascale , Karimi Maryam , Michiels Stefan , Raimbourg Judith , Daniel Catherine , Janicot Henri , Madroszyk Anne , Audigier-Valette Clarisse , Quoix Elisabeth , Mazieres Julien , Moro-Sibilot Denis , Dansin Eric , Molinier Olivier , Morel Hugues , Pichon Eric , Cortot Alexis , Otto Josiane , Chomy François , Souquet Pierre-Jean , Cloarec Nicolas , Giroux-Leprieur Etienne , Bieche Ivan , Lacroix Ludovic , Boyault Sandrine , Attignon Valery , Soubeyran Isabelle , Morel Alain , Tran-Dien Alicia , Jacquet Alexandra , Dall'Olio Filippo Gustavo , Jimenez Marta , Soria Jean-Charles , Besse Benjamin
Published: April 2023

Study protocol
Supplementary Table S4 from Frequent Overexpression of HER3 in Brain Metastases from Breast and Lung Cancer
Authors: Tomasich Erwin , Steindl Ariane , Paiato Christina , Hatziioannou Teresa , Kleinberger Markus , Berchtold Luzia , Puhr Rainer , Hainfellner Johannes A. , Müllauer Leonhard , Widhalm Georg , Eckert Franziska , Bartsch Rupert , Heller Gerwin , Preusser Matthias , Berghoff Anna Sophie
Published: April 2023

Differentially methylated CpG sites in HER3+ vs HER3- breast cancer samples (Luminal cohort)
Supplementary Table S3 from Frequent Overexpression of HER3 in Brain Metastases from Breast and Lung Cancer
Authors: Tomasich Erwin , Steindl Ariane , Paiato Christina , Hatziioannou Teresa , Kleinberger Markus , Berchtold Luzia , Puhr Rainer , Hainfellner Johannes A. , Müllauer Leonhard , Widhalm Georg , Eckert Franziska , Bartsch Rupert , Heller Gerwin , Preusser Matthias , Berghoff Anna Sophie
Published: April 2023

Differentially methylated CpG sites in HER3+ vs HER3- breast cancer samples (HER2+ cohort)
Supplementary Figure S3 from Frequent Overexpression of HER3 in Brain Metastases from Breast and Lung Cancer
Authors: Tomasich Erwin , Steindl Ariane , Paiato Christina , Hatziioannou Teresa , Kleinberger Markus , Berchtold Luzia , Puhr Rainer , Hainfellner Johannes A. , Müllauer Leonhard , Widhalm Georg , Eckert Franziska , Bartsch Rupert , Heller Gerwin , Preusser Matthias , Berghoff Anna Sophie
Published: April 2023

Immune cell infiltration in BM of the three subtypes of BCa: Luminal (A), HER2-positive (B) and Triple-negative breast cancer (TNBC) (C).
Supplementary Figure S1 from Frequent Overexpression of HER3 in Brain Metastases from Breast and Lung Cancer
Authors: Tomasich Erwin , Steindl Ariane , Paiato Christina , Hatziioannou Teresa , Kleinberger Markus , Berchtold Luzia , Puhr Rainer , Hainfellner Johannes A. , Müllauer Leonhard , Widhalm Georg , Eckert Franziska , Bartsch Rupert , Heller Gerwin , Preusser Matthias , Berghoff Anna Sophie
Published: April 2023

Further evaluation of HER3 expression in BM of breast and lung cancer.
Data from SALVO: Single Arm Trial of Ipilimumab and Nivolumab as Adjuvant Therapy for Resected Mucosal Melanoma
Authors: Kottschade Lisa A. , Pond Gregory Russell. , Olszanski Anthony J. , Zakharia Yousef , Domingo-Musibay Evidio , Hauke Ralph J. , Curti Brendan D. , Schober Sarah , Milhem Mohammed M. , Block Matthew S. , Hieken Tina , McWilliams Robert R.
Published: April 2023

Abstract
Background: Mucosal melanoma is a rare, aggressive form of melanoma with extremely high recurrence rates despite definitive surgical resection with curative intent. Currently there is no consensus on adjuvant therapy. Data on checkpoint inhibitors (CPI) for adjuvant therapy is lacking. Methods: We performed a single arm, multicenter clinical trial using “flip dose” ipilimumab (1mg/kg q3w x4 cycles), and nivolumab (3 mg/kg q3w x4 cycles), then Nivolumab 480 mg q4w x 11 cycles to complete a year of adjuvant therapy. Participants must have had R0/R1 resection <90 days prior to registration, no prior systemic therapy (adjuvant radiation allowed), ECOG 0/1, no uncontrolled autoimmune disease or other invasive cancer. Patients were recruited through the Midwest Melanoma Partnership/Hoosier Oncology Network. Results: From Sept 2017 to August 2021 35 patients enrolled. Of these, 29 (83%) had R0 resections, and 7 (20%) received adjuvant radiation. Median age was 67 years, 21 (60.0%) female. Relapse-free survival rates at 1 and 2 years were 50% (95% CI 31-66%) and 37% (95% CI 19-55%), respectively. Overall survival rates at 1 and 2 years were 87% (95% CI 68-95%) and 68% (95% CI 46-83%), respectively. Median RFS was 14.3 m (95% CI 5.7-25.8). Most common grade 3 toxicities were diarrhea (14%), hypertension (14%), and hyponatremia (11%), with no grade 4/5 toxicities. Conclusions: Flip dose ipilimumab and nivolumab after resection of mucosal melanoma is associated with outcomes improved over that of surgical resection alone. Long term follow up, subgroup analyses and correlative studies are ongoing.
Data from Osimertinib and selpercatinib efficacy, safety, and resistance in a multicenter, prospectively treated cohort of EGFR-mutant and RET fusion-positive lung cancers
Authors: Rotow Julia , Patel Jyoti D. , Hanley Matthew P. , Yu Helena , Awad Mark , Goldman Jonathan W. , Nechushtan Hovav , Scheffler Matthias , Kuo Chih-Hsi S. , Rajappa Senthil , Harada Guilherme , Clifford Sarah , Santucci Alison , Silva Laura , Tupper Rebecca , Oxnard Geoffrey R. , Kherani Jennifer , Drilon Alexander
Published: April 2023

Abstract
Purpose: Acquired RET fusions have been reported at resistance to treatment with EGFR inhibitors in EGFR-mutant non-small cell lung cancer (NSCLC), however, a multicenter cohort of patients with EGFR-mutant lung cancers treated with osimertinib and selpercatinib for RET fusion-mediated osimertinib resistance has not previously been published. Patients and methods: Patients who received selpercatinib in combination with osimertinib on a prospective expanded access clinical trial (NCT03906331) and single-patient compassionate use programs across five countries were centrally analyzed. All patients had advanced EGFR-mutant NSCLC with a RET fusion detected from tissue or plasma following osimertinib therapy. Clinicopathologic and outcomes data were collected. Results: Fourteen patients with EGFR-mutant and RET fusion-positive lung cancers who experienced prior progression on osimertinib received osimertinib and selpercatinib. EGFR exon 19 deletions (±T790M, 86%) and non-KIF5B fusions (CCDC6-RET 50%, NCOA4-RET 36%) predominated. Osimertinib 80mg daily and selpercatinib 80mg twice daily were the most commonly administered dosages. The response rate, disease control rate, and median treatment duration were 50% (95%CI 25%-75%, n=12), 83% (95%CI 55%-95%%), and 7.9 months (range 0.8-25+), respectively. Resistance was complex, involving EGFR on-target (EGFR C797S), RET on-target (RET G810S), and off-target (EML4-ALK/STRN-ALK, KRAS G12S, BRAF V600E) mechanisms, RET fusion loss, or polyclonal mechanisms. Conclusions: For patients with EGFR-mutant NSCLC with an acquired RET fusion as a mechanism of EGFR inhibitor resistance, the addition of selpercatinib to osimertinib was feasible, safe, and offered clinical benefit, supporting the prospective evaluation of this combination.
Supplementary Figure Legends from Tumor-Derived CCL5 Recruits Cancer-Associated Fibroblasts and Promotes Tumor Cell Proliferation in Esophageal Squamous Cell Carcinoma
Authors: Dunbar Karen J. , Karakasheva Tatiana A. , Tang Qiaosi , Efe Gizem , Lin Eric W. , Harris Michael , Sahu Varun , Sachdeva Uma M. , Hu Jianhua , Klein-Szanto Andres J. , Henick Brian , Diehl J. Alan , Nakagawa Hiroshi , Rustgi Anil K.
Published: April 2023

Supplementary Figure Legends 1-4
Supplementary Figure 4 from Tumor-Derived CCL5 Recruits Cancer-Associated Fibroblasts and Promotes Tumor Cell Proliferation in Esophageal Squamous Cell Carcinoma
Authors: Dunbar Karen J. , Karakasheva Tatiana A. , Tang Qiaosi , Efe Gizem , Lin Eric W. , Harris Michael , Sahu Varun , Sachdeva Uma M. , Hu Jianhua , Klein-Szanto Andres J. , Henick Brian , Diehl J. Alan , Nakagawa Hiroshi , Rustgi Anil K.
Published: April 2023

Targeted CCR5 inhibition replicates CCL5 loss with reduced tumor cell proliferation in vitro and in vivo.
Supplementary Table S1 from Mitochondrial Metabolism Drives Low-density Lipoprotein-induced Breast Cancer Cell Migration
Authors: Nóbrega-Pereira Sandrina , Santos Francisco , Oliveira Santos Miguel , Serafim Teresa L. , Lopes Ana Patrícia , Coutinho Diogo , Carvalho Filipa S. , Domingues Rosário M. , Domingues Pedro , Bernardes de Jesus Bruno , Morais Vanessa A. , Dias Sérgio
Published: April 2023

List of primers used for measurements of gene expression levels and mtDNA content by quantitative real-time PCR.
Supplementary Figure S8 from Mitochondrial Metabolism Drives Low-density Lipoprotein-induced Breast Cancer Cell Migration
Authors: Nóbrega-Pereira Sandrina , Santos Francisco , Oliveira Santos Miguel , Serafim Teresa L. , Lopes Ana Patrícia , Coutinho Diogo , Carvalho Filipa S. , Domingues Rosário M. , Domingues Pedro , Bernardes de Jesus Bruno , Morais Vanessa A. , Dias Sérgio
Published: April 2023

Uncropped membranes relative to the western blot for Drp1, Mfn1, Mfn2 and b-ACTIN proteins displayed in Fig. 2J
Supplementary Figure S7 from Mitochondrial Metabolism Drives Low-density Lipoprotein-induced Breast Cancer Cell Migration
Authors: Nóbrega-Pereira Sandrina , Santos Francisco , Oliveira Santos Miguel , Serafim Teresa L. , Lopes Ana Patrícia , Coutinho Diogo , Carvalho Filipa S. , Domingues Rosário M. , Domingues Pedro , Bernardes de Jesus Bruno , Morais Vanessa A. , Dias Sérgio
Published: April 2023

¬Reactive oxygen species formation downstream of mitochondria fatty acid entry is required for LDL-induced migration of breast cancer cells. Related to Fig. 6
Supplementary Figure S6 from Mitochondrial Metabolism Drives Low-density Lipoprotein-induced Breast Cancer Cell Migration
Authors: Nóbrega-Pereira Sandrina , Santos Francisco , Oliveira Santos Miguel , Serafim Teresa L. , Lopes Ana Patrícia , Coutinho Diogo , Carvalho Filipa S. , Domingues Rosário M. , Domingues Pedro , Bernardes de Jesus Bruno , Morais Vanessa A. , Dias Sérgio
Published: April 2023

LDL-induced migratory behavior of TNBC cells relies in fatty acid transport into the mitochondria. Related to Fig. 5
Supplementary Figure S3 from Mitochondrial Metabolism Drives Low-density Lipoprotein-induced Breast Cancer Cell Migration
Authors: Nóbrega-Pereira Sandrina , Santos Francisco , Oliveira Santos Miguel , Serafim Teresa L. , Lopes Ana Patrícia , Coutinho Diogo , Carvalho Filipa S. , Domingues Rosário M. , Domingues Pedro , Bernardes de Jesus Bruno , Morais Vanessa A. , Dias Sérgio
Published: April 2023

LDL-induced breast cancer cell migration is mediated by the fatty acid transporter CD36. Related to Fig. 3
Supplementary Figure S1 from Mitochondrial Metabolism Drives Low-density Lipoprotein-induced Breast Cancer Cell Migration
Authors: Nóbrega-Pereira Sandrina , Santos Francisco , Oliveira Santos Miguel , Serafim Teresa L. , Lopes Ana Patrícia , Coutinho Diogo , Carvalho Filipa S. , Domingues Rosário M. , Domingues Pedro , Bernardes de Jesus Bruno , Morais Vanessa A. , Dias Sérgio
Published: April 2023

LDL-exposed breast cancer cells show differential invasion potential and metastatic tropism to distant sites in xenotransplanted zebrafish larvae at 4dpi (6dpf). Related to Fig. 1.
Figure S8 from Dissecting the origin of heterogeneity in uterine and ovarian carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: April 2023

Alteration of genes of RAS pathway in uterine and ovarian CS.
Figure S5 from Dissecting the origin of heterogeneity in uterine and ovarian carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: April 2023

BRCAness feature: tandem duplicator phenotype.
Figure S14 from Dissecting the origin of heterogeneity in uterine and ovarian carcinosarcomas
Authors: Sertier Anne-Sophie , Ferrari Anthony , Pommier Roxane M. , Treilleux Isabelle , Boyault Sandrine , Devouassoux-Shisheboran Mojgan , Kielbassa Janice , Thomas Emilie , Tonon Laurie , Le Texier Vincent , Charreton Amandine , Morel Anne-Pierre , Floquet Anne , Joly Florence , Berton-Rigaud Dominique , Ferron Gwenaël , Arnould Laurent , Croce Sabrina , Bataillon Guillaume , Saintigny Pierre , Mery-Lamarche Eliane , Sagan Christine , Senaratne Aruni P. , Gut Ivo G. , Calvo Fabien , Viari Alain , Ouzounova Maria , Ray-Coquard Isabelle , Puisieux Alain
Published: April 2023

Complete clonal evolution of P05 tumor.
Baricentro: teoria, construções e problemas
Authors:   Universidade de São Paulo. Faculdade de Zootecnia e Engenharia de Alimentos, Lópes Linares Juan
Published: April 2023

Entre os centros de triângulos o baricentro ou centroide é o mais conhecido devido a sua grande utilização em diversos campos da Matemática e Física. A discussão neste e-book é organizada em três capítulos: Fundamentos teóricos; Construções, exercícios e desafios; Problemas de olimpíadas internacionais. Este material didático foi utilizado durante algumas das aulas do curso "Geometria Olímpica com GeoGebra" para professores de Matemática do Ensino Fundamental e Médio de todo o Brasil. O texto conta com 42 figuras que facilitam acompanhar a resolução. Todas têm como complemento links para os gráficos interativos no site do GeoGebra e, vários, a resolução em vídeo do YouTube. O diferencial na utilização do GeoGebra está baseado na disponibilidade gratuita do software, tanto online como aplicativos para computadores e celulares. As construções geométricas podem ser feitas de forma dinâmica, onde exploram-se diversas configurações de um mesmo problema. O GeoGebra serve tanto como calculadora gráfica e numérica, utilizada para a verificação, como ferramenta para a apresentação, passo a passo, de uma demonstração rigorosa. O GeoGebra também convida o leitor a interagir, a pôr as mão na massa.
Mourning Women
Authors: Drumsta Emily
Published: April 2023

This article examines two modern women poets’ ambivalent engagements with Arabic elegy: the Iraqi Nazik al-Malaʾikah and the Egyptian Iman Mersal. Although they wrote in different national contexts and historical eras, with utterly distinct political and aesthetic projects, a close look at their verse reveals a specter of the bereft-yet-eloquent “ancient Arab woman” haunting their respective poetic voices. Looking in particular at a conventionally metered and rhymed ode like al-Malaʾikah’s “To My Late Aunt” (Ila ʿAmmati al-Rahilah) and at the quasi-elegiac threads woven through the prose poems in Mersal’s 1992 collection, A Dark Corridor Suitable for Learning How to Dance (Mamarr Muʾtam Yuslah Li-Taʿallum al-Raqs) allows us to see how durable and omnipresent the woman-elegy association is in Arabic – surfacing everywhere from the heyday of Iraqi modernism, with its revaluation of conventional metrical forms, all the way through the unmetered, unrhymed experimentations of the “nineties generation” in Egypt.
“Maybe nothing is an elegy”
Authors: Bardazzi Adele
Published: April 2023

This article investigates two central aspects of contemporary elegy: (1) the plausible and tempting assumption of it being disentangled from formal constraints, something that might have generated a major historical shift from poetry as a poetic form to an elegiac mode of discourse (Bardazzi, Giusti, and Tandello 2022); (2) the formal glitch it creates and, at times, reconciles via the lyric and its generative tension between personal and collective, narrative and non-narrative dimensions, linear and non-linear temporalities. This study does so by focusing on two authors who have weaved together a poetics of mourning the paternal figure: OBIT (2020) by the Asian American poet Victoria Chang and Geologia di una padre [Geology of a father] (2013) by the Italian poet Valerio Magrelli.
A new species of the rare genus Rutaraphes Jałoszyński from Japan (Coleoptera, Staphylinidae, Scydmaeninae)
Authors: JAŁOSZYŃSKI PAWEŁ
Published: April 2023

To date, the stenichnine genus Rutaraphes Jałoszyński includes only two species: R. shikokuensis Jałoszyński (Japan) and R. taiwanicus Jałoszyński (Taiwan), both known from a single holotype male. Consequently, Rutaraphes can be placed among the rarest Palaearctic genera of Scydmaeninae. Three males of this remarkable genus were found recently during a museum survey, all collected in a flight intercept trap in Central Honshū, Japan. They represent a new species, described herein as Rutaraphes honshuensis sp. n., morphologically close to R. shikokuensis.
A new genus and species of gall midge (Diptera: Cecidomyiidae: Cecidomyiidi) with notes on adult cecidomyiid mouthparts and their terminology
Authors: GAGNÉ RAYMOND J. , HUERTA HERON
Published: April 2023

Camillemyia prominens Gagné, gen. n. et sp. n., (Diptera: Cecidomyiidae; Cecidomyiinae) is described for a gall midge from Mexico with an extremely elongate neck and proboscis. The external and internal basic composition of the proboscis of Cecidomyiidae, as exemplified by Cecidomyia resinicola Osten Sacken, is reviewed to help understand the structural changes found in Cam. prominens as compared to those of Contarinia prolixa Gagné & Byers, another species with spectacularly modified mouthparts.