bluuebunny/crossref_metadata_2025 huggingface dataset:
Immune Responses of Healthy Pregnant Women following an Elective Cesarean Section: Effects of Anesthetic Procedures
Authors: Novac Marius Bogdan , Boldeanu Lidia , Dijmărescu Anda Lorena , Boldeanu Mihail Virgil , Neamțu Simona Daniela , Radu Lucreţiu , Manolea Maria Magdalena , Șerbănescu Mircea-Sebastian , Stoica Maria , Rotaru Luciana Teodora , Văduva Constantin-Cristian
Published: April 2024

A weakened immune system and more inflammatory cytokines being released are possible effects of the surgical stress that a cesarean section induces. This kind of reaction, in addition to the altered reaction to catecholamines, has the potential to significantly affect the immune system of the mother and the patients’ general postoperative course. This prospective study compared the plasma levels of catecholamines and cytokines in healthy pregnant patients having cesarean sections under spinal anesthesia versus general anesthesia. A total of 30 pregnant women undergoing elective cesarean sections were divided into two groups: 15 who received general anesthesia (GA) and 15 who received spinal anesthesia (SA). Blood samples were collected from all subjects before anesthesia induction (pre-OP), 6 h postoperatively (6 h post-OP), and 12 h (12 h post-OP), to measure levels of tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6), IL-8, IL-4, IL-10, norepinephrine (NE), and epinephrine (EPI). When we compared the two groups, we discovered that only IL-6 and IL-4 had significantly higher levels pre-OP, whereas all studied cytokines exhibited an increase in the GA versus SA group at 6 and 12 h post-OP. In the case of catecholamines, we discovered that serum levels are positively related with pro-inflammatory or anti-inflammatory cytokines, depending on the time of day and type of anesthetic drugs. Compared to SA, GA has a more consistent effect on the inflammatory response and catecholamine levels. The findings of this study confirm that the type of anesthesia can alter postoperative immunomodulation to various degrees via changes in cytokine and catecholamine production. SA could be a preferable choice for cesarean section because it is an anesthetic method that reduces perioperative stress and allows for less opioid administration, impacting cytokine production with proper immunomodulation.
Patlak Slope versus Standardized Uptake Value Image Quality in an Oncologic PET/CT Population: A Prospective Cross-Sectional Study
Authors: Ince Semra , Laforest Richard , Itani Malak , Prasad Vikas , Ashrafinia Saeed , Smith Anne M. , Wahl Richard L. , Fraum Tyler J.
Published: April 2024

Patlak slope (PS) images have the potential to improve lesion conspicuity compared with standardized uptake value (SUV) images but may be more artifact-prone. This study compared PS versus SUV image quality and hepatic tumor-to-background ratios (TBRs) at matched time points. Early and late SUV and PS images were reconstructed from dynamic positron emission tomography (PET) data. Two independent, blinded readers scored image quality metrics (a four-point Likert scale) and counted tracer-avid lesions. Hepatic lesions and parenchyma were segmented and quantitatively analyzed. Differences were assessed via the Wilcoxon signed-rank test (alpha, 0.05). Forty-three subjects were included. For overall quality and lesion detection, early PS images were significantly inferior to other reconstructions. For overall quality, late PS images (reader 1 [R1]: 3.95, reader 2 [R2]: 3.95) were similar (p > 0.05) to early SUV images (R1: 3.88, R2: 3.84) but slightly superior (p ≤ 0.002) to late SUV images (R1: 2.97, R2: 3.44). For lesion detection, late PS images were slightly inferior to late SUV images (R1 only) but slightly superior to early SUV images (both readers). PS-based TBRs were significantly higher than SUV-based TBRs at the early time point, with opposite findings at the late time point. In conclusion, late PS images are similar to early/late SUV images in image quality and lesion detection; the superiority of SUV versus PS hepatic TBRs is time-dependent.
Comparison of Ultrasound Attenuation Imaging Using a Linear versus a Conventional Convex Probe: A Volunteer Study
Authors: Hänni Olivia , Ruby Lisa , Paverd Catherine , Frauenfelder Thomas , Rominger Marga B. , Martin Alexander
Published: April 2024

The study aimed to investigate the feasibility of attenuation imaging (ATI) measurements using a linear probe on healthy volunteers and compare measurements with the conventional convex probe. Attenuation imaging measurements of the liver tissue were taken using ultrasound with a convex and a linear probe in 33 volunteers by two examining doctors, and the measurements were repeated 4–5 weeks later by one of them. The ATI values for the linear probe were in the range of the values for the convex probe for both examiners. Measurements did not change significantly for 32 out of 33 volunteers after 4–5 weeks when using the linear probe. The size of the region of interest (ROI) only impacted the ATI values for the convex probe; it did not affect the values taken with the linear probe. Healthy volunteers were measured, and their attenuation values were compared to those from a convex probe, commonly used in steatosis evaluation. When both probes were positioned in the same liver area, they showed good agreement in attenuation values, though depth significantly affected the measurements, with both probes providing different values at different depths. The study’s results aligned with previous research using the same system. Operator A and B’s results were compared, demonstrating similar ranges of values for both probes. The linear probe has been demonstrated to allow for superficial measurements and attain ATI values in line with that of the convex probe in the liver.
Flavor’s Delight
Authors: Nilles Hans Peter , Ramos-Sánchez Saúl
Published: April 2024

Discrete flavor symmetries provide a promising approach to understand the flavor sector of the standard model of particle physics. Top-down (TD) explanations from string theory reveal two different types of such flavor symmetries: traditional and modular flavor symmetries that combine to the eclectic flavor group. There have been many bottom-up (BU) constructions to fit experimental data within this scheme. We compare TD and BU constructions to identify the most promising groups and try to give a unified description. Although there is some progress in joining BU and TD approaches, we point out some gaps that have to be closed with future model building.
Unveiling the Future of Human and Machine Coding: A Survey of End-to-End Learned Image Compression
Authors: Huang Chen-Hsiu , Wu Ja-Ling
Published: April 2024

End-to-end learned image compression codecs have notably emerged in recent years. These codecs have demonstrated superiority over conventional methods, showcasing remarkable flexibility and adaptability across diverse data domains while supporting new distortion losses. Despite challenges such as computational complexity, learned image compression methods inherently align with learning-based data processing and analytic pipelines due to their well-suited internal representations. The concept of Video Coding for Machines has garnered significant attention from both academic researchers and industry practitioners. This concept reflects the growing need to integrate data compression with computer vision applications. In light of these developments, we present a comprehensive survey and review of lossy image compression methods. Additionally, we provide a concise overview of two prominent international standards, MPEG Video Coding for Machines and JPEG AI. These standards are designed to bridge the gap between data compression and computer vision, catering to practical industry use cases.
Exploring Student Agency in Narratives of English Literacy Events across School Subjects
Authors: Warnby Marcus
Published: April 2024

In contemporary academia, English-language reading assignments are prevalent, even in contexts where English is not the primary medium of instruction nor the local language. This presents a challenge for students with English as a foreign language (EFL) who seek to pursue a university education in their home country. This study investigates the presence of English literacy events in Swedish upper secondary schools outside of English classes and explores their implications for university readiness and educational equity. Using survey data from 163 EFL students and qualitative content analysis, students’ written comments revealed a notable absence of English literacy events in non-English subjects, with limited exposure to written English texts and occasional use of multimodal English activities. The findings underscore disparities in students’ opportunities to engage with academic English literacy practices, primarily influenced by individual factors. This paper delves into the interplay between individual dimensions, and institutional and social practices, in shaping student agency in English academic literacy practices.
ClosedLoop Control of Pulse-Density-Modulated Wireless Power Transfer with Fast MEPT
Authors: Wang Ke , Jiang Haiyue , Peng Jing , Li Hongchang
Published: April 2024

Efficient wireless power transfer (WPT) requires closedloop control to perform maximum efficiency point tracking (MEPT) against the dynamic changes of operating conditions. In this paper, we took the latest deltasigma pulse-density-modulated (PDM) WPT system as the plant and presented a systematic control design procedure. The WPT system was modeled by the reducedorder dynamic phasor method and further decoupled under the tuned condition. It was identified that the coupled resonators behave like a secondorder system, and its natural frequency is much lower than the resonant frequency. This was considered in the closedloop design to derive a suitable loop gain and ensure stability. The nonlinearity caused by the dualside PDM control is limited to a small inner loop so that the entire loop is linear and simple. Experimental results showed that the closedloop voltage regulation and MEPT took only about 10 ms after load stepping. The system DC output voltage was always tightly regulated, and the steadystate efficiency was very close to the theoretical maximum value under different coupling conditions.
Attribute-Based Searchable Encryption: A Survey
Authors: Yan Li , Wang Gaozhou , Yin Tian , Liu Peishun , Feng Hongxin , Zhang Wenbin , Hu Hailin , Pan Fading
Published: April 2024

With the advent of the big data era, the size and complexity of data continue to increase, which makes the requirement for data privacy and security increasingly urgent. However, traditional encryption methods cannot meet the demand for efficient searching in large-scale datasets. To solve this problem and enable users to search within encryped data and without decrypting the entire dataset, trapdoor functions and other cryptograhic techniques are introduced in searchable encryption. However, searchable encryption still cannot meet the needs in the real world. Therefore, researchers have introduced the concept of attribute-based encryption into searchable encryption, resulting in attribute-based searchable encryption (ABSE). This approach aims to achieve efficient search by attributes in encrypted datasets. ABSE has a wide range of applications in the fields of privacy protection, data sharing, and cloud computing. In this paper, we describe the trends in development, focusing on enhancing security, improving computational efficiency, and increasing flexibility. We also present the related schemes. In addition, several common application areas are introduced and the relevant schemes proposed by researchers are summarized. Moreover, the challenges and future directions of ABSE are discussed in this paper.
Estimation of Fuel Properties for the Heavy Fraction of Biomass Pyrolysis Oil Consisting of Proposed Structures for Pyrolytic Lignin and Humins
Authors: Terrell Evan
Published: April 2024

The organic component of biomass pyrolysis oils is composed of a light fraction (C2–C4 volatiles, sugar- and lignin-derived monomers) and a less polar heavy fraction (pyrolytic lignin/humins, greater than approximately 200 g/mol). Importantly, this heavy fraction can account for roughly one-third to one-half of the total pyrolysis oil. While the composition and characteristics of the light fraction are generally well understood, research is still needed for the characterization of the heavy fraction. Some important thermodynamic fuel properties of this fraction are the heat of combustion, normal boiling point, heat of vaporization, and flash point, which are (computationally) estimated in this work with regularized regression and empirical correlations. The quantification of these properties has implications on downstream utilization, particularly in the context of co-processing bio-oils with plastic and coal liquefaction products and/or crude petroleum. Finally, challenges and opportunities for (experimental) work are discussed for the advancement of sustainable valorization of biomass pyrolysis oils.
A Systematic Review on Fuzzy Decision Support Systems and Multi-Criteria Analysis in Urban Heat Island Management
Authors: Ćesić Majda , Rogulj Katarina , Kilić Pamuković Jelena , Krtalić Andrija
Published: April 2024

The phenomenon known as urban heat islands (UHIs) is becoming more common and widespread, especially in large cities and metropolises around the world. The main cause of these temperature variations between the city center and the suburbs is the replacement of large tracts of natural land with artificial (built-up) surfaces that absorb solar heat and radiate it back at night. UHIs have been the subject of numerous studies, most of which were about defining the main characteristics, factors, indexes, etc., of UHIs using remote sensing technologies or about determining mitigating activities. This paper provides a comprehensive overview of the literature, as well as a bibliometric analysis, to discover research trends related to the application of decision support systems and multi-criteria decision-making for UHI management, with a special emphasis on fuzzy theory. Data collection is conducted using the Scopus bibliographic database. Throughout the literature review, it was found that there were not many studies on multi-criteria analysis and decision support system applications regarding UHIs. The fuzzy theory application was also reviewed, resulting in only a few references. However, this topic is current, with an increase in published papers, and authors see this as an opportunity for improvement and further research.
Applications of Oxyhydrogen, Direct Water Injection, and Early-Intake Valve Closure Technologies on a Petrol Spark Ignition Engine—A Path towards Zero-Emission Hydrogen Internal Combustion Engines
Authors: Kong Xiangtao , Wang Yaodong
Published: April 2024

This study investigates the performance of a 4-MIX engine utilizing hydrogen combustion in pure oxygen, water injection, and the application of the early-intake valve closure (EIVC) Miller cycle. Transitioning from a standard petrol–oil mix to hydrogen fuel with pure oxygen combustion aims to reduce emissions. Performance comparisons between baseline and oxyhydrogen engines showed proportional growth in the energy input rate with increasing rotational speed. The oxyhydrogen engine exhibited smoother reductions in brake torque and thermal efficiency as rotational speed increased compared to the baseline, attributed to hydrogen’s higher heating value. Water injection targeted cylinder and exhaust temperature reduction while maintaining a consistent injected mass. The results indicated a threshold of around 2.5 kg/h for the optimal water injection rate, beyond which positive effects on engine performance emerged. Investigation into the EIVC Miller cycle revealed improvements in brake torque, thermal efficiency, and brake specific fuel consumption as early-intake valve closure increased. Overall, the EIVC model exhibited superior energy efficiency, torque output, and thermal efficiency compared to alternative models, effectively addressing emissions and cylinder temperature concerns.
Morpho-Anatomical Characteristics and Volatile Profiles of Pinus nigra J.F.Arnold from the Balkan Peninsula and Southern Carpathians
Authors: Mitić Zorica S. , Nikolić Biljana M. , Stojković Jelena P. , Jevtović Snežana Č. , Stojanović Gordana S. , Zlatković Bojan K. , Marin Petar D.
Published: April 2024

This is the first report on morpho-anatomical and phytochemical differentiation of 19 native populations representing different Pinus nigra J.F.Arnold subspecies (banatica (Borbás) Novák, dalmatica (Vis.) Franco, nigra, and pallasiana (Lamb.) Holmboe) in the Balkans and Southern Carpathians. The 9 morpho-anatomical characteristics and 10 headspace volatiles of needles were analyzed with multivariate statistical analyses. The combination of results from all multivariate analyses with both types of markers revealed that P. nigra is differentiated into three groups within the studied area (the Dalmatian coast, Greece, and the rest of the Balkans with the Southern Carpathians). The first group included the population from an island in Dalmatia that corresponds to P. nigra subsp. dalmatica. The third group consisted of populations from continental Croatia, Bosnia and Herzegovina, Serbia, Romania, and Bulgaria, which corresponds to P. nigra subsp. nigra. In light of the recent molecular data that indicated that the Greek populations (the second group) represent a distinct genetic lineage of P. nigra placed between the populations from the principal area (P. nigra subsp. nigra) and Turkey (P. nigra subsp. pallasiana), one can speculate that there is one more subspecies of P. nigra in this region that corresponds to populations from Greece. Extending our analyses to Asia Minor and Crimea could bring additional results that would be valuable for clarifying the intriguing issue of the diversification of P. nigra in the eastern part of its range.
Mixed-Species Stands Improve the Coordination between Leaf and Fine Root Traits in a Common Garden Experiment
Authors: Li Yuxin , Zhang Cancan , Cheng Yiqing , Zeng Shiqi , Yang Shiyun , Lin Xiaofan , Shi Jianmin , Bu Wensheng
Published: April 2024

The coordination between leaf and root traits is conducive to an integrated understanding of whole-plant ecological strategies and reveals how community composition and diversity contribute to defining the functions and services of ecosystems. However, there is limited understanding regarding the impact of species richness and trait categories on the coordination between leaf and root traits. Based on a 9-year common garden experiment, we investigated the leaf and fine root traits of 56 plots (25.8 m × 25.8 m) encompassing various trait categories (trait categories were defined according to the root depth, leaf habit, and mycorrhizal type) and different levels of species richness (1, 2, 4, 8) in the context of a forest biodiversity and ecosystem functioning experiment conducted in subtropical China (BEF-China). We found the following: (1) Our findings indicate that there was generally a significant difference in leaf traits, occasionally in absorptive root traits, and no difference in transport root traits between different trait categories. (2) Conversely, species richness significantly influenced all transport root traits except root nitrogen and most leaf and absorptive root traits. (3) The results demonstrated that trait categories played a crucial role in the coordination between leaf and fine root traits. Additionally, the coordination between leaf and fine root traits increased with higher species richness, particularly in deep-rooted, evergreen, and ectomycorrhizal fungi species. Furthermore, the coordination between leaf and fine root traits was significantly lower in monocultures compared to four- and eight-species mixtures. These results suggest that a significant mixture effect exists in the coordination between leaf and fine root traits due to the comprehensive and divergent capture of above- and belowground resources and reduced intraspecific competition. Therefore, compared to monocultures, mixed-species stands can enhance the coordination of leaf and fine root traits, and it is advisable to establish forests with mixtures of more than four species, dominated by deep-rooted, evergreen, and ectomycorrhizal fungi species, to maintain ecosystem stability and functional integrity.
Combatting Climate Change within the EU Green Deal in Contemporary Forestry Administrative Systems: A Case Study of the Umbria Region
Authors: Barbarese Francesco , Andreopoulou Zacharoula S. , Mattioli Walter , Oreti Loredana , Carbone Francesco
Published: April 2024

The integration of digital technologies into forest management is crucial for the European Union’s Green Deal, the Forestry Strategy 2030, and Italy’s national forestry strategy, aiming to enhance governance and efficiency. However, sustainable forest management’s administrative aspects are often overlooked, despite the potential for digital tools to significantly improve environmental performance. Through a Life Cycle Assessment (LCA) for a case study in the Umbria region, the research quantifies CO2 emissions associated with over-threshold forestry administrative procedures under both current and future digitalisation scenarios. Data were collected from legislative documents, interviews with forestry professionals, and emissions calculated according to ISO standards. The findings reveal a considerable reduction in CO2 emissions through digitalisation, from 75.07 kgCO2 to 38.14 kgCO2, with the implementation of the LIFE FOLIAGE project’s digital platform. This underscores digitalisation’s role in climate change mitigation, highlighting the significant, albeit modest per procedure, of the cumulative national impact. The main findings support further digitalisation in forest management as a method of increasing resource efficiency and reducing greenhouse gas emissions, thus contributing to the Green Deal’s and Italy’s forest sustainability goals.
Exploring Adult Eating Behaviors and Food Neophobia: A National Study in Romania
Authors: Bugi Meda-Ada , Jugănaru Iulius , Simina Iulia-Elena , Nicoară Delia-Maria , Cristun Lucian-Ioan , Brad Giorgiana-Flavia , Boru Casiana , Cîrnatu Daniela , Mărginean Otilia
Published: April 2024

Food neophobia involves avoiding new foods due to reluctance, aversion, or disgust. The Food Neophobia Scale (FNS) is the most reliable and common adult food neophobia test. It helps compare food neophobia across cultures by being translated into numerous languages. This study adapted, translated, and validated the FNS for Romania. This translated version was piloted in November 2023 on 59 students in the medical field from two distinct Romanian cities. Between December 2023 and February 2024, 375 adults were surveyed, representing Romania’s population within a 90% confidence interval. The average age of responders was 38.07 years, with a standard deviation of 10.75 and a 4:1 female-to-male sex ratio. The Cronbach’s alpha test was used to validate the questionnaire. Our study found that the mean FNS value was 31.86; most Romanian respondents (69.20%) were neutral towards trying new foods, with a significant portion being neophobes (18.21%) outnumbering neophiles (12.59%). When compared to international study results, Romanian adults, on average, exhibited a higher percentage of neophobes compared to those in Korea (13%), Hungary (16.8%), Italy (17%), and Brazil (17.5%), but a lower percentage than those in Lebanon (21.5%). The findings indicate that the translated scale can be utilized to assess neophobia among Romanian speakers.
Preliminary Study on the Pathogenic Mechanism of Jujube Flower Disease in Honeybees (Apis mellifera ligustica) Based on Midgut Transcriptomics
Authors: Du Yali , Xu Kai , Zhao Huiting , Wu Ying , Jiang Haibin , He Jinming , Jiang Yusuo
Published: April 2024

Honeybees are prone to poisoning, also known as jujube flower disease, after collecting nectar from jujube flowers, resulting in the tumultuous demise of foragers. The prevalence of jujube flower disease has become one of the main factors affecting the development of the jujube and beekeeping industries in Northern China. However, the pathogenic mechanisms underlying jujube flower disease in honeybees are poorly understood. Herein, we first conducted morphological observations of the midgut using HE-staining and found that jujube flower disease-affected honeybees displayed midgut damage with peritrophic membrane detachment. Jujube flower disease was found to increase the activity of chitinase and carboxylesterase (CarE) and decrease the activity of superoxide dismutase (SOD), catalase (CAT), glutathione S-transferase (GST), and the content of CYP450 in the honeybee midgut. Transcriptomic data identified 119 differentially expressed genes in the midgut of diseased and healthy honeybees, including CYP6a13, CYP6a17, CYP304a1, CYP6a14, AADC, and AGXT2, which are associated with oxidoreductase activity and vitamin binding. In summary, collecting jujube flower nectar could reduce antioxidant and detoxification capacities of the honeybee midgut and, in more severe cases, damage the intestinal structure, suggesting that intestinal damage might be the main cause of honeybee death due to jujube nectar. This study provides new insights into the pathogenesis of jujube flower disease in honeybees.
Preservation of 5-Hydroxymethylcytosine Levels in LRIG1 across Genomic DNA and Cell-Free DNA in Glioma Patients
Authors: Jevšinek Skok Daša , Bolha Luka , Hauptman Nina
Published: April 2024

Cell-free DNA (cfDNA) has recently emerged as a promising minimally invasive diagnostic biomarker for various cancers. In this study, our aim was to identify cfDNA biomarkers by investigating genes that displayed significant differences between glioma patients and their corresponding controls. To accomplish this, we utilized publicly available data from the Gene Expression Omnibus, focusing on 5-hydroxymethylcytosine (5hmC) profiles in both cfDNA and genomic DNA (gDNA) from glioma patients and healthy individuals. The intersection of gene lists derived from these comparative analyses unveiled LRIG1 and ZNF703 as the two genes with elevated 5hmC levels in both the cfDNA of glioma patients and gDNA of glioma tissue compared to their respective controls. The gene expression data revealed both genes were upregulated in glioma tissue compared to normal brain tissue. Integration of 5hmC data revealed a strong positive correlation in the glioma tissue group between 5hmC and the gene expression of the LRIG1 gene. Furthermore, exploration using the AmiCa web tool indicated that LRIG1 gene expression was elevated compared to 17 other cancers included in the database, emphasizing its potential as a distinctive biomarker across multiple cancer types.
Characterization of a New Variant in ARHGAP31 Probably Involved in Adams–Oliver Syndrome in a Family with a Variable Phenotypic Spectrum
Authors: Santaniello Carlo , Faversani Alice , Corsaro Luigi , Melloni Giulia , Motta Silvia , Mandorino Elena , Sacco Davide , Stioui Sabine , Ferrara Fulvio , Barteselli Davide , De Vita Dario , Manuelli Debora , Costantino Lucy
Published: April 2024

Adams–Oliver syndrome is a rare inherited condition characterized by scalp defects and limb abnormalities. It is caused by variants in different genes such as ARHGAP31. Here, we used an interdisciplinary approach to study a family with lower limb anomalies. We identified a novel variant in the ARHGAP31 gene that is predicted to result in a truncated protein with a constitutively activated catalytic site due to the loss of 688 amino acids involved in the C-terminal domain, essential for protein auto-inhibition. Pathogenic variants in ARHGAP31 exon 12, leading to a premature protein termination, are associated with Adams–Oliver syndrome. Bioinformatic analysis was useful to elucidate the impact of the identified genetic variant on protein structure. To better understand the impact of the identified variant, 3D protein models were predicted for the ARHGAP31 wild type, the newly discovered variant, and other pathogenetic alterations already reported. Our study identified a novel variant probably involved in Adams–Oliver syndrome and increased the evidence on the phenotypic variability in patients affected by this syndrome, underlining the importance of translational research, including experimental and bioinformatics analyses. This strategy represents a successful model to investigate molecular mechanisms involved in syndrome occurrence.
Thousands of Induced Earthquakes per Month in West Texas Detected Using EQCCT
Authors: Chen Yangkang , Savvaidis Alexandros , Saad Omar M. , Siervo Daniel , Huang Guo-Chin Dino , Chen Yunfeng , Grigoratos Iason , Fomel Sergey , Breton Caroline
Published: April 2024

West Texas has been a seismically active region in the past decade due to the injection of industrial wastewater and hydrocarbon exploitation. The newly founded Texas seismological network has provided a catalog that characterizes the intense seismicity down to a magnitude of 1.5 Ml. However, there are numerous small-magnitude events (Ml < 1.0) occurring every day that are not analyzed and reported, due to the prohibitively high workload to manually verify the picks from automatic picking methods. We propose to apply an advanced deep learning method, the earthquake compact convolutional transformer (EQCCT), to unleash our power in analyzing hundreds of small earthquakes per day in West Texas. The EQCCT method is embedded in an integrated-detection-and-location framework to output a highly complete earthquake catalog, given a list of available seismic stations, in a seamless way. The EQCCT has enabled us to detect and locate 50-times more earthquakes (mostly smaller than magnitude 1) than we previously could. We applied the EQCCT-embedded detection and location workflow to the Culberson and Mentone earthquake zone (CMEZ) in West Texas and detected thousands of earthquakes per month for consecutively three months. Further relocation of the new catalog revealed an unprecedentedly high-resolution and precise depiction of shallow and deep basement-rooted faults. The highly complete catalog also offers significant insights into the seismo-tectonic status of the CMEZ. Association with nearby injection activities also revealed a strong correlation between the rate of injected fluid volume and the number of small earthquakes.
Typology of Parent-to-Child Emotions: A Study of Japanese Parents of a Foetus up to a 12-Year-Old Child
Authors: Hada Ayako , Ohashi Yukiko , Usui Yuriko , Kitamura Toshinori
Published: April 2024

Background: Emotions are the fundamental origin of parent–child bonding, which is measurable by the Scale for Parent-to-Child Emotions (SPCE) based on the theories of basic and self-conscious emotions. Methods: This study is based on the data from a cross-sectional study that we previously reported. The data consist of fathers and mothers who had a child/children, whose eldest child’s age was at the foetal stage up to 12 years old, and were recruited via the Internet (N = 4600). A series of cluster analyses using factor scores (theta[Ө]s) of all domains of the SPCE were conducted. After the clusters emerged, the fathers and mothers allocated to each cluster were compared by the child’s age stage. The validation of the classifications was also conducted using ANOVAs and chi-squared tests. A discriminant function analysis was conducted. Results: The participant mothers and fathers were classified into Cluster 1 (Lack of Bonding Emotions, n = 509), Cluster 2 (Bonding Disorder, n = 1471), Cluster 3 (Ambivalent Bonding Emotions, n = 1211), and Cluster 4 (Positive Bonding, n = 1409). Across the four clusters, there were no differences in the age of the parents or the gender of the child. During the second trimester, mothers made up the majority of Cluster 4 (Positive Bonding), totalling 81 cases (37.5%), whereas fathers made up the majority of Cluster 2 (Bonding Disorder), totalling 126 cases (60.0%). The three linear discriminants (LDs) well predicted the four clusters, and their functions showed cross validation. Conclusions: The typology of the SPCE is helpful to understand individual differences in terms of parental emotional bonding.
Exploring the Threefold Viewpoint on Children’s Oral Health in a Cross-Sectional Study
Authors: Perpelea Anca-Cristina , Sfeatcu Ruxandra , Tușaliu Mihail , Tănase Mihaela , Meleșcanu Imre Marina , Ripszky Totan Alexandra , Funieru Cristian , Nicolescu Dragoș Nicolae , Pițuru Silviu-Mirel
Published: April 2024

Oral health is situated within the framework of the global health agenda, addressing facets pertaining to well-being and quality of life. The research is based on the need to address variables at the community level to improve schoolchildren’s oral health and promote healthy behaviors and aims to carry out an in-depth analysis from the perspective of the factors that influence children’s oral health. Step 1, designed by the World Health Organization, was utilized. An easy-to-use web interface was created for data collection. The statistical analysis consisted of using multinomial and binominal logistic regression models. The level of education of the adult has a high probability of influencing the consumption of unhealthy or healthy foods, it has a significant probability of exerting influence on social or medical problems and a correlation was found between the level of academic education and the pattern of dental visits. The development of health-promoting behaviors begins in childhood and involves parents, who have an essential role in the education of their children. Oral health promotion programs in schools need to target the child–adult–teacher–dentist relationships. Taking into consideration the aforementioned, a threefold viewpoint is necessary for the development of a national program aimed at promoting the oral health of schoolchildren in Romania.
Exploring the Role of Healthcare Personnel in Designing Tuberculosis Infection Prevention and Control Measures in Healthcare Settings: A Scoping Review
Authors: Masuku Sikhethiwe , Mooa Ramadimetja Shirley , Peu Mmapheko Doriccah
Published: April 2024

Background: Healthcare personnel (HCP) in high TB-burdened countries continue to be at high risk of occupational TB due to inadequate implementation of Tuberculosis Infection Prevention and Control (TB-IPC) measures and a lack of understanding of the context and relevance to local settings. Such transmission in the healthcare workplace has prompted the development and dissemination of numerous guidelines for strengthening TB-IPC for use in settings globally. However, a lack of involvement of healthcare personnel in the conceptualisation and development of guidelines and programmes seeking to improve TB-IPC in high-burden countries generally has been observed. Objectives: The aim of this review was to explore the inclusion of HCP in decision-making when designing the TB-IPC guidelines, in healthcare settings. Methods: A scoping review methodology was selected for this study to gain insight into the relevant research evidence, identifying and mapping key elements in the TB-IPC measures in relation to HCP as implementors. Results: Studies in this review refer to factors related to HCP’s knowledge of TB-IPC, perception regarding occupational risks and behaviours, their role against a background of structural resource constraints, and guidelines’ adherence. They report several challenges in TB-IPC implementation and adherence, particularly eliciting recommendations from HCP for improved TB-IPC practices. Conclusions: This review highlights a lack of participation in decision-making by the implementers of the policies and guidelines, yet adherence to TB-IPC measures is anticipated. Future research needs to focus more on consultations with users to understand the preferences from both within individual healthcare facilities and the communities. There is an urgent need for research on the participation of the implementers in the decision-making when developing TB-IPC policies and guidelines.
Utilisation of Reproductive Health Services among Adolescents in Ghana: Analysis of the 2007 and 2017 Ghana Maternal Health Surveys
Authors: Ehiawey James Tetteh-Boawolor , Manu Adom , Modey Emefa , Ogum Deda , Atuhaire Edgar , Torpey Kwasi
Published: April 2024

Early pubertal development induces early sexual activities among adolescents. In Ghana, despite the high sexual activity among Ghanaian adolescents, sexual and reproductive health (SRH) services are underutilised, primarily due to SRH stigma and a lack of SRH knowledge and information. This study examined the use of SRH services among adolescents aged 15–19 years in Ghana over a ten year period. The study utilised data from the 2007 and 2017 Ghana Maternal Health Surveys (GMHSs). Responses from 2056 and 4909 adolescent females captured in the 2007 and 2017 GMHSs, respectively, were used. The results showed a declining utilisation of SRH services among adolescents from 28.3% in 2007 to 22.5% in 2017. The odds of using family planning among sexually active adolescents increased from 2007 [AOR-0.32, CI-(0.135, 0.77), p < 0.001] to 2017 [AOR-68.62, CI-(36.104, 130.404), p < 0.001]. With increasing age at first sex, adolescents were less likely to use a family planning method in 2007 [AOR-0.94, CI-(0.89,0.99) p < 0.001], but this improved in 2017 [AOR-1.26, CI-(1.220, 1.293), p < 0.001]. Despite this, knowledge of sources for family planning was found to predict its lower utilisation in both 2007 [AOR = 0.15 (95% CI-0.081, 0.283), p < 0.0001] and 2017 [AOR = 0.206 (95% CI-(0.099, 0.426), p < 0.001]. The findings show that even though knowledge of family planning methods predicted low utilisation, knowledge of sources, age at first sex, and educational level positively predicted the utilisation of SRH services from 2007 to 2017. Opportunities for both enhancing the clinical environment and health provider attitudes exist and should be explored for improving SRH outcomes among sexually active adolescents in Ghana.
Comparing Mediators and Moderators of Mental Health Outcomes from the Implementation of Group Problem Management Plus (PM+) among Venezuelan Refugees and Migrants and Colombian Returnees in Northern Colombia
Authors: Miller-Suchet Lucy , Camargo Natalia , Sangraula Manaswi , Castellar Diany , Diaz Jennifer , Meriño Valeria , Chamorro Coneo Ana Maria , Chávez David , Venegas Marcela , Cristobal Maria , Bonz Annie G. , Ramirez Camilo , Trejos Herrera Ana Maria , Ventevogel Peter , Brown Adam D. , Schojan Matthew , Greene M. Claire
Published: April 2024

Colombia hosts the largest number of refugees and migrants fleeing the humanitarian emergency in Venezuela, many of whom experience high levels of displacement-related trauma and adversity. Yet, Colombian mental health services do not meet the needs of this population. Scalable, task-sharing interventions, such as Group Problem Management Plus (Group PM+), have the potential to bridge this gap by utilizing lay workers to provide the intervention. However, the current literature lacks a comprehensive understanding of how and for whom Group PM+ is most effective. This mixed methods study utilized data from a randomized effectiveness-implementation trial to examine the mediators and moderators of Group PM+ on mental health outcomes. One hundred twenty-eight migrant and refugee women in northern Colombia participated in Group PM+ delivered by trained community members. Patterns in moderation effects showed that participants in more stable, less marginalized positions improved the most. Results from linear regression models showed that Group PM+-related skill acquisition was not a significant mediator of the association between session attendance and mental health outcomes. Participants and facilitators reported additional possible mediators and community-level moderators that warrant future research. Further studies are needed to examine mediators and moderators contributing to the effectiveness of task-shared, scalable, psychological interventions in diverse contexts.
Investigating Factors Associated with Migration and Cultural Adaptation in Relation to Change in Attitudes and Behavior towards Female Genital Mutilation/Cutting (FGM/C) among Populations from FGM/C-Practicing Countries Living in Western Countries: A Scoping Review
Authors: Salah Nasteha , Cottler-Casanova Sara , Petignat Patrick , Abdulcadir Jasmine
Published: April 2024

A growing body of evidence indicates a significant decrease in support for female genital mutilation/cutting (FGM/C) within post-migration communities in Western countries. Addressing knowledge gaps and comprehending the factors associated with FGM/C discontinuation in these communities is crucial. The objective of this scoping review is to describe the effects of migration and cultural change on factors supporting FGM/C cessation in migrant communities. The review, from 2012 to 2023, included the following databases: Embase, PubMed, Google Scholar, Swisscovery, CINAHL, APA PsycInfo, and gray literature. Applying the PRISMA-ScR framework, we identified 2819 studies, with 17 meeting the inclusion criteria. The results revealed seven key factors shaping attitudes and behavior toward FGM/C abandonment: (1) legislation against FGM/C, (2) knowing that FGM/C is not a religious requirement, (3) enhancing education about the practice, (4) migration and cultural change, (5) awareness of the harmful effects of FGM/C, (6) a positive view of uncut girls, and (7) a sense of self-agency. These findings highlight factors on a social, community, interpersonal, and personal level that enhance the abandonment of the practice. Further research in the FGM/C field will gain more accuracy in understanding and accounting for these multilevel factors in post-migration settings, offering valuable insights for targeted interventions to promote the cessation of the practice.
Verification of AKT and CDK5 Gene and RNA Interference Combined with Irradiation to Mediate Fertility Changes in Plutella xylostella (Linnaeus)
Authors: Wen Jiaqi , Wang Mengran , Zeng Yuhao , He Fengting , Li Shifan , Zhang Ke , Weng Qunfang
Published: April 2024

Plutella xylostella (Linnaeus) mainly damages cruciferous crops and causes huge economic losses. Presently, chemical pesticides dominate its control, but prolonged use has led to the development of high resistance. In contrast, the sterile insect technique provides a preventive and control method to avoid the development of resistance. We discovered two genes related to the reproduction of Plutella xylostella and investigated the efficacy of combining irradiation with RNA interference for pest management. The results demonstrate that after injecting PxAKT and PxCDK5, there was a significant decrease of 28.06% and 25.64% in egg production, and a decrease of 19.09% and 15.35% in the hatching rate compared to the control. The ratio of eupyrene sperm bundles to apyrene sperm bundles also decreased. PxAKT and PxCDK5 were identified as pivotal genes influencing male reproductive processes. We established a dose-response relationship for irradiation (0–200 Gy and 200–400 Gy) and derived the irradiation dose equivalent to RNA interference targeting PxAKT and PxCDK5. Combining RNA interference with low-dose irradiation achieved a sub-sterile effect on Plutella xylostella, surpassing either irradiation or RNA interference alone. This study enhances our understanding of the genes associated with the reproduction of Plutella xylostella and proposes a novel approach for pest management by combining irradiation and RNA interference.
TGFβ-Responsive Stromal Activation Occurs Early in Serrated Colorectal Carcinogenesis
Authors: Tsumuraya Hideaki , Okayama Hirokazu , Katagata Masanori , Matsuishi Akira , Fukai Satoshi , Ito Misato , Sakamoto Wataru , Saito Motonobu , Momma Tomoyuki , Nakajima Shotaro , Mimura Kosaku , Kono Koji
Published: April 2024

Activated TGFβ signaling in the tumor microenvironment, which occurs independently of epithelial cancer cells, has emerged as a key driver of tumor progression in late-stage colorectal cancer (CRC). This study aimed to elucidate the contribution of TGFβ-activated stroma to serrated carcinogenesis, representing approximately 25% of CRCs and often characterized by oncogenic BRAF mutations. We used a transcriptional signature developed based on TGFβ-responsive, stroma-specific genes to infer TGFβ-dependent stromal activation and conducted in silico analyses in 3 single-cell RNA-seq datasets from a total of 39 CRC samples and 12 bulk transcriptomic datasets consisting of 2014 CRC and 416 precursor samples, of which 33 were serrated lesions. Single-cell analyses validated that the signature was expressed specifically by stromal cells, effectively excluding transcriptional signals derived from epithelial cells. We found that the signature was upregulated during malignant transformation and cancer progression, and it was particularly enriched in CRCs with mutant BRAF compared to wild-type counterparts. Furthermore, across four independent precursor datasets, serrated lesions exhibited significantly higher levels of TGFβ-responsive stromal activation compared to conventional adenomas. This large-scale analysis suggests that TGFβ-dependent stromal activation occurs early in serrated carcinogenesis. Our study provides novel insights into the molecular mechanisms underlying CRC development via the serrated pathway.
Podophyllic Aldehyde, a Podophyllotoxin Derivate, Elicits Different Cell Cycle Profiles Depending on the Tumor Cell Line: A Systematic Proteomic Analysis
Authors: Hernández Ángela-Patricia , Chaparro-González Lorea , Garzo-Sánchez Olga , Arias-Hidalgo Carlota , Juanes-Velasco Pablo , García Pablo A. , Castro Mª Ángeles , Fuentes Manuel
Published: April 2024

When new antitumor therapy drugs are discovered, it is essential to address new target molecules from the point of view of chemical structure and to carry out efficient and systematic evaluation. In the case of natural products and derived compounds, it is of special importance to investigate chemomodulation to further explore antitumoral pharmacological activities. In this work, the compound podophyllic aldehyde, a cyclolignan derived from the chemomodulation of the natural product podophyllotoxin, has been evaluated for its viability, influence on the cell cycle, and effects on intracellular signaling. We used functional proteomics characterization for the evaluation. Compared with the FDA-approved drug etoposide (another podophyllotoxin derivative), we found interesting results regarding the cytotoxicity of podophyllic aldehyde. In addition, we were able to observe the effect of mitotic arrest in the treated cells. The use of podophyllic aldehyde resulted in increased cytotoxicity in solid tumor cell lines, compared to etoposide, and blocked the cycle more successfully than etoposide. High-throughput analysis of the deregulated proteins revealed a selective antimitotic mechanism of action of podophyllic aldehyde in the HT-29 cell line, in contrast with other solid and hematological tumor lines. Also, the apoptotic profile of podophyllic aldehyde was deciphered. The cell death mechanism is activated independently of the cell cycle profile. The results of these targeted analyses have also shown a significant response to the signaling of kinases, key proteins involved in signaling cascades for cell proliferation or metastasis. Thanks to this comprehensive analysis of podophyllic aldehyde, remarkable cytotoxic, antimitotic, and other antitumoral features have been discovered that will repurpose this compound for further chemical transformations and antitumoral analysis.