bluuebunny/crossref_metadata_2025 huggingface dataset:
Letter to Editor: Potential Use of Meldonium as Supportive Treatment in Lifestyle Diseases
Authors: Grzesiak Magdalena , Szymański Oskar
Published: September 2024

Meldonium, a drug more familiar in the sports world than in clinical medicine, acts as a structural analog of gamma-butyrobetaine and influences carnitine metabolism by inhibiting gamma-butyrobetaine hydroxylase. This results in reduced carnitine levels, decreased fatty acid β-oxidation, and increased glucose utilization. Such metabolic shifts are advantageous in conditions of low oxygen availability, making meldonium a substance of interest for its potential cardioprotective effects. Animal studies suggest that meldonium can reduce infarct size, enhance cardiac recovery post-ischemia, and improve cardiac function by attenuating ventricular dysfunction. Additionally, meldonium has demonstrated beneficial effects on glucose metabolism and endothelial function in diabetes models. Recent research also highlights its potential in mitigating neuronal damage and enhancing survival in high-altitude brain injury models. Despite these promising findings, human clinical trials are necessary to confirm meldonium’s efficacy and safety for treating major lifestyle diseases such as heart failure, type 2 diabetes, and ischemic heart disease. The current evidence base is limited by small-scale studies and outdated treatment protocols. Thus, large-scale, double-blind randomized trials are essential to clarify the drug’s therapeutic potential and to address significant gaps in knowledge surrounding its clinical use.
Comprehensive Management of Premature Skin Aging: Current Strategies, Treatments, and Emerging Therapies
Authors: Ziobro Anna , Camlet Katarzyna , Kocur Kinga , Lis Paulina
Published: September 2024

Introduction and Aim. Premature skin aging results from both intrinsic and extrinsic factors, requiring a comprehensive management strategy. This review evaluates current and emerging approaches for preventing and treating premature skin aging, focusing on efficacy and safety.Materials and Methods. A review of recent scientific literature on topical, oral, and procedural interventions for managing premature skin aging was conducted.Analysis of Literature. Topical treatments, particularly retinoids and antioxidants, are key in skin regeneration and oxidative stress reduction. Oral interventions, including systemic retinoids and nutraceuticals, support overall skin health. Procedural methods like laser therapies, microneedling, and chemical peels are effective in skin rejuvenation. Preventive measures, such as photoprotection and lifestyle changes, are crucial. Emerging therapies, such as stem cell treatments, show promise in reversing age-related skin changes.Conclusion. Managing premature skin aging requires a combination of topical, oral, and procedural treatments with preventive strategies. Future research should focus on refining protocols, assessing novel therapies' long-term safety, and developing personalized approaches considering genetic, environmental, and lifestyle factors.
Prawne i polityczne konsekwencje wyroku Trybunału Sprawiedliwości z dnia 6 września 2017 roku w sprawie Republiki Słowackiej i Węgier przeciwko Radzie Unii Europejskiej w przedmiocie skargi o stwierdzenie nieważności decyzji (UE) 2015/1601
Authors: Pietras-Eichberger Marta
Published: September 2024

LEGAL AND POLITICAL CONSEQUENCES OF THE JUDGMENT OF THE COURT OF JUSTICE OF 6 SEPTEMBER 2017 IN THE CASE OF THE SLOVAK REPUBLIC AND HUNGARY V COUNCIL OF THE EUROPEAN UNION ON THE ACTION FOR ANNULMENT OF DECISION (EU) 2015/1601The subject of the paper is the analysis of the judgment of the Court of Justice in joined cases C-643/15 and C-647/15 annulment of Council Decision (EU) 2015/1601 of 22.09.2015 establishing provisional measures in the area of international protection for the benefit of Italy and Greece. The Republic of Poland intervenes in the allegations raised in the complaint against the Council of the EU. The study will present the context, genesis and content of the contested decision, as well as the arguments of the parties and the assessment of individual allegations by the Court. The decision was taken in response to the migration crisis in the Mediterranean, which prompted the EU institutions to take solidarity measures in favour of frontline countries. The decision provides, e.g., for the relocation of persons who have applied for international protection from Italy and Greece to the territory of other Member States. The aim of the paper is to examine the impact of the judgment of the Court of Justice on the shape of immigration policy manifested in the practice of EU Member States and EU institutions. The study mainly uses the legalanalytical method. Selected acts of primary and secondary EU law and judgments of the Court of Justice were subjected to legal analysis.
Autonomia parlamentów narodowych w hybrydowym systemie Unii Europejskiej
Authors: Czachór Zbigniew
Published: September 2024

AUTONOMY OF NATIONAL PARLIAMENTS IN THE HYBRID SYSTEM OF THE EUROPEAN UNION
This article aims to prove the hypothesis that the European Union has become a subsidiarily independent entity, with a hybrid character that combines supra‑national, supra-state and national (state) elements. This makes member states and their parliamentary representations occupy an autonomous position in the EU power system, creating and implementing their own functions and interests. The article was prepared based on neo-functionalist, but also neo-realist premises. Both of these paradigms are present in the theory of representation, which distinguishes representation of national parliaments as acting “on behalf of someone” and representation as acting “on its own behalf ”. For this reason, the article substantiates its author’s belief that national parliaments in the European Union act in a hybrid manner, not least because they simultaneously represent their states (governments) and the EU institutions, but also themselves as autonomous and independent subjects of EU power.
Impact of the European Green Deal Strategy on the Evolution of EU Regional Policy after 2021
Authors: Michalewska-Pawlak Małgorzata
Published: September 2024

The article’s primary goal is to define how establishing the European Green Deal (EGD) development strategy has influenced changes in the European Union’s (EU’s) regional policy programming and implementation. The subject of the analysis is the objectives and financial instruments of the EU regional policy for the years 2021-2027, which have been programmed taking into account the priorities defined in the EGD strategy. The article will verify the hypothesis regarding the impact of the EU’s strategic principles on the paradigm shift in the EU regional policy. European Union development priorities focused on climate neutrality, environmental protection, and biodiversity require implementing a regional policy centred on specific horizontal goals common to all EU regions. The author argues that as a result, the territorial aspect of implementing the EU regional policy weakens, reflected in the arrangement of its goals and the directions of intervention of structural funds in the Multiannual Financial Framework (MFF) 2021-2027.
Management in the Renewable Energy Sector in the European Union Countries
Authors: Tomala Magdalena
Published: September 2024

Management in the field of the Green Deal in the European Union (EU) has become a pivotal goal in recent years as the region continues to prioritise sustainability and combat climate change. The EU has established ambitious goals to transition towards a greener and more sustainable energy landscape. This transformation needs strategic management practices that encompass various aspects of the sector. The aim of this article is to analyse the correlation between the variables X – the share of renewable energy in final energy consumption and Y – CO2 emissions. The paper assumes that there is a correlation between the variables studied. The study did not confirm this hypothesis for all EU countries, but only for a selected group. Due to the variables analysed, the countries were grouped using the k-means method, which made it possible to identify the leaders, middle countries and marauders of the Green Transformation.
Programa Vida em Movimento: a Experiência de Uruguaiana-Rio Grande do Sul
Authors: Bueno Lidiele Roque , Carvalho Alex , Ribas Nathalie Yelena Plucinski Cardoso , Guerra Paulo Henrique , Cunha Álvaro Luis Avila da
Published: September 2024

Considerando os impactos da prática da atividade física (AF) à melhoria da saúde em nível populacional, o objetivo deste trabalho é descrever o histórico, objetivo, funcionamento e modelo do “Programa Vida em Movimento” (PVM), coordenado pelo município de Uruguaiana-Rio Grande do Sul. Trata-se de uma pesquisa documental, com finalidade descritiva. Profissionais de Educação Física conduzem aulas em 19 unidades de saúde, abrangendo cerca de 700 usuários. Os resultados sugerem a potencialidade do PVM à expansão do Sistema Único de Saúde no que diz respeito à promoção de AF na perspectiva de direito, alinhada à promoção da saúde. O PVM destaca a viabilidade de integrar efetivamente a AF nas políticas públicas de saúde.
Personality types of cadets (Using Myers-Briggs Types Indicator)
Authors: Chung Sun Young
Published: September 2024

The purpose of this study was to examine personality type of cadets and personality type characteristics, as measured by the MBTI, was to refer most broadly educational advice. The subjects consisted 288 cadets of the Armed Forces Nursing Academy from May to September, 1994.The results of this study reported a significantly higher percentage of The type, ISTJ(18.4 percent), and ESTJ (12.5 percent) among MBTI 16 Types.The Type ENFJ(1.39 percent), ENTJ (1.74 percent) were a least percentage among MBTI 16 Types.And analysis of variance was employed to determine :The relationship of the four MBTI perception, judgment preference. (S,N, F, T) Psychological functional preference measured ST(47.2%)，SF(30.50%)，NT(10.06%), psychological temperament were SJ (48%), SP(29.5%).From the above results, personality characteristics of the majority cadets were enjoyed seeing immediate, result of action and can make decision quickly and effectively use whatever inform is avaiable and there was a larger percentage of person who tended to be practical realistic present — oriented organized and who to deal effectively with factual information.Further research be better suited to a specific area of teaching.
Sleep Change of Older Adults and Nursing Research
Authors: Song Mi soon , Kim Shin mi , Oh Jin Joo
Published: September 2024

Elderly is the fastest growing population among all age group and sleep impairment is one of the most frequent complaint found in older adults.Efforts are underwayed to help the client with sleep impairment by nursing researchers. However, there are only a few nursing literatures regarding sleep in general, and none for elderly in Korea to date.The purpose of this review is to examine researches related to sleep in elderly for its content, methodology, perspectives, and theory in order to suggest potential research thrusts. Since little research has been done by nursing scholars and the sleep research is interdisciplinary, the review was conducted through all the available literatures by authors regardless the specialty because of their rel evance to nursing.Sleep is an essential component for health and the quality of life of individuals. Normally, sleep pattern changes with advancing age. These changes often result in sleep impairment followed by various problems such as fatigue, drowsiness, anxiety, po tential injury, cognition decline, physical problems, and etc.Nurses are in the best position to prevent, monitor, evaluate and intervene for sleep problems of elderly, by their work charateristics of 24hour around clock work for patients and primary health work involvement. In order to encourage more nursing research related to sleep, the state of art of sleep research has been reviewed and organized by follow ing categories : sleep pattern change in later life ;factors related to sleep impairment ; nursing intervention and nursing research considerations. It is suggested that nursing researches on sleep of Korean elderly is needed to identify the sleep pattern change to determine the extent of the problems and to develop nursing strategies feasible for Korean elderly, for better quality of life of older adults.
Theoretical models of Causative Factors in Drinking Behaviors : A Review of the Literature for Nursing Practice and Reaserch
Authors: Gong Su ja
Published: September 2024

The purpose of this literature review was to explore theoretical models of dinking behaviors for their potential usefulness in nusing research and practice.Drinking behaviors are related to biopsychosocial factors. According to recent epidemiological surveys, the alcoholic problems in Korea were serious, but research of drinking behavios in Korea was not sufficient for full understanding of alcoholic disorders and drinking behaviors in terms of biopsychosocial factors.Although reaserch on the causes of drinking behaviors has traditionally been heavily influenced by pharmacological and genetic explnations, recent findings have drawn attention to social-cognitive theories as a potentially critical element in etiological matrix.Any useful theoretical model for drinking behavior must address at least the following three questions. First, why do people start drinking? Second, what factors maintain drinking? Third, why do some drink as to develop serious problems? To answer these questions, many theoretical models for drinking behaviors were developed so far.7 theories were reviewed in this article : The disease models, Learning theories, Social Cognitive theories, Biological theories, Personality theories, Psychoanalytical theories and Socio-cultural theories.Each of these theories explains the causative factors of drinking behaviors but do not allow the answer for above questions alone. Development of more comprehensive model is needed. More prospective, longitudinal studies are needed before a certain theory can be recommended.This article will contribute to develop a comprehesive thory and to facilitate the fruitful reaserch for drinking behaviors in the future.
The Effects of Self Understanding and Family System Functioning Group Theraphy on the SelfEsteem of Nursing Students
Authors: Ahn Hwang-Ran , Pai Hang-Ja
Published: September 2024

The purpose of this study was to identify the effects of Self Understanding and Family System Functionung Group Theraphy on the change of self-esteem of nursing students.The study is based on 100 Group Theraphy sessions conducted for one year and six months.The paticipants were 72 junior nursing students v어io were on the clinical practice of psychiatric ward. Each group was composed of 6-8 nursing students and it took ten times(90 minutes at one time) for two weeks.The program was consisted of self understanding, family system functioning, studenfs presentation, and modeling.Data were collected from March, 1994 to July 1995 with 72 nursing students who were on the clinical practice of psychiatric ward in Gyeongsang University Hospital(Chinju city).The 72 students were measured by using self-esteem scale before and after the group theraphy on the self-esteem of nursing students.The data were analyzed by an SPSS computerized program and included Paired t-test to examine the pre-post differences of the group theraphy. As the result. Hypothesis, “self-esteem of nursing students will be enhanced after self understanding and family system functioning group theraphy” was accepted (P<.001).In conclusion, self understanding and family system functuoning group theraphy is efficient for improving the level of self-esteem of nursing students.
Os caminhos sócio-históricos da comunidade quilombola Mussuca (Laranjeiras/Sergipe)
Authors: Silva Jacson Baldoino , Almeida Norma Lucia Fernandes de , Araújo Silvana Silva de Farias
Published: September 2024

Este artigo apresenta vestígios históricos da comunidade remanescente de quilombo Mussuca (Laranjeiras/Sergipe) tendo em vista a importância da documentação linguística de comunidades afro-brasileiras do Estado de Sergipe (Santana; Araújo; Freitag, 2018a, 2018b). Com isso, a partir de uma revisão bibliográfica, discorremos sobre a presença africana na formação histórica do Brasil, particularmente na região do rio Cotinguiba (SE), à beira do qual nasceu o município de Laranjeiras, onde a Mussuca está situada. Por fim, concluímos que os dados apresentados evidenciam a alegada origem afrodescendente da comunidade, mas também demonstra que, ainda nos dias de hoje, há uma manutenção dessa afrodescendência através das práticas culturais africanizadas existentes na comunidade quilombola
Estratégias de implicatura em ameaças veladas: uma possível contribuição à determinação de significados em Linguística Forense
Authors: Silva Welton Pereira e
Published: September 2024

Procuramos apresentar uma orientação metodológica para o trabalho do linguista forense em tarefas de determinação de significados implícitos. O corpus é composto por quinze cartas de ameaça escritas em português do Brasil, analisadas por meio de concepções da Pragmática (Grice, 1991), da Semântica (Ducrot, 1987; Lakoff; Johnson, 2003; Quadros-Gomes; Sanchez-Mendes, 2018) e de teorias do discurso (Charaudeau, 2008; 2015; Fiorin, 2016). As noções de implicatura conversacional e de máxima conversacional foram relacionadas à de sentidos de língua e sentidos de discurso, evidenciando que seis estratégias de implicatura orientam a organização discursiva das ameaças veladas: o emprego de (i) metáforas; (ii) eufemismos; (iii) disfemismos; (iv) elipses; (v) vagueza e (vi) pressuposição.
Como montar uma rede construcional: uma abordagem por Escalonamento Multidimensional em 2D e 3D para os adjetivos adverbiais do português brasileiro
Authors: Adelino Sara Martins , Pinheiro Diogo
Published: September 2024

Adelino e Diogo (no prelo) propõem que os adjetivos adverbiais (AAs) do português brasileiro podem ser agrupados em oito classes semânticas, que correspondem a uma construção gramatical de nível intermediário. Neste estudo, verificamos a realidade psicológica dessa proposta por meio de experimento de julgamento de proximidade semântica. Os dados foram analisados por meio de Escalonamento Multidimensional, técnica que permite gerar representações de clusters de exemplares em duas e três dimensões. A representação em 2D revelou a existência de cinco (meso)construções de adjetivo adverbial, ao passo que a representação em 3D indica a postulações de sete (meso)construções. As representações geradas revelaram a distribuição de diferentes microconstruções de adjetivos adverbiais e fornecem evidências em favor da existência de classes semânticas específicas para a Construção de Adjetivo Adverbial mais geral.
Visées et effets du discours néolibéral dans les médias : une interview avec Thierry Guilbert
Authors: Guilbert Thierry , Adorno Guilherme , Fatima Wellton da Silva de
Published: September 2024

Dans cette interview, le professeur émérite et chercheur Thierry Guilbert, de l'Université de Picardie Jules Verne, en France, est interviewé par Guilherme Adorno et Wellton da Silva de Fatima. Les intervieweurs interrogent le chercheur sur son parcours académique, ses recherches, ses principales découvertes et aussi sur sa relation de recherche avec le Brésil. L'auteur explique en détail les aspects de ses enquêtes sur le discours néolibéral dans les médias français, avec une richesse d'exemples et un ton assez décontracté, malgré la rigueur théorique et analytique.
CONDIÇÕES TRABALHISTAS NA EDUCAÇÃO INFANTIL BRASILEIRA
Authors: Augusto Franco Celso
Published: September 2024

O aqui presente texto tem por objetivo central estudar a relação entre as condições trabalhistas na educação e a Educação Infantil na cidade de Barra Mansa-RJ. O estudo se fraciona em duas partes: na fundamentação teórica baseada na proletarização do professor, e no recorte das condições trabalhistas dos profissionais da Educação Infantil na cidade. No primeiro, ao relacionar a conjuntura política de subdesenvolvimento latino-americano com o subdesenvolvimento educacional, junto à luz dos textos de Marx abordando a proletarização, demonstra-se a relação inicial do trabalhador no capitalismo, para, assim, desmistificar qualquer ideal diferente do professor e do profissional de educação como um proletário. Já no segundo, discute-se as relações de trabalho, tomando os profissionais que trabalham em sala: Professor, Auxiliar de Recreação e Agente de Apoio à Educação Inclusiva. Deste modo, faz-se um debate a partir desse contexto político, com as contra reformas iniciadas com Michel Temer e, como base concreta, tomando a questão salarial como referência.
PERFIL DO PEDAGOGO SOCIAL NO CENTRO DE REFERÊNCIA DE ASSISTÊNCIA SOCIAL – CRAS
Authors: RODRIGUES VANESSA ELISABETE RAUE , De Oliveira Cândida Mirela Aires
Published: September 2024

A presente investigação tem por objetivo propor uma reflexão sobre a atuação do pedagogo em espaços educativos não formais, especificamente no Centro de Referência de Assistência Social – CRAS, diferenciando as especificações do trabalho pedagógico desse profissional dentro desses ambientes. Esta pesquisa busca refletir sobre a atuação do Pedagogo dentro dos espaços da Assitência Social, em especial no Serviço de Convivência e Fortalecimento de Vínculos – SCFV. Iniciamos a reflexão sobre o contexto da Pedagogia Social e a sua viabilidade na sociedade, após apresentar o pedagogo como profissional que traz suas atribuições e contribuições de uma visão que vão além do educar, estendendo suas mediações até a Assistência Social, especificamente os CRAS – Centro de Referência de Assistência Social. A opção metodológica foi a pesquisa bibliográfica, a qual permitiu compreender que o pedagogo tem contribuições significativas no CRAS para a formação cidadã dos educandos, representando um apoio para a equipe frente à superação das vulnerabilidades sociais e dificuldades, através das suas intervenções socioeducacionais. A pedagogia social é sinônimo de luta e resistência, e está na contramão dos processos históricos-educativos autoritários, centralizadores, antiéticos, excludentes, balizados na meritocracia e alienação.
PEDAGOGIA E CINEMA COMO ARTE EM ESCOLAS DA REDE PÚBLICA
Authors: De Oliveira Ribeiro Danielle
Published: September 2024

Este artigo tem por objetivo problematizar a presença do cinema nas escolas públicas. Propõe-se a apresentar o cinema como criação, tanto através da análise de obras já existentes, quanto da produção de imagens/filmes pelos estudantes junto aos professores. Tal perspectiva está ancorada nos estudos e na experiência de trabalho de Alain Bergala, para quem a escola deve ser um espaço de apropriação e fruição do cinema como arte. Essa proposta não se opõe às práticas mais comuns de uso de filmes nas escolas, mas expande as possibilidades pedagógicas do cinema. Destacam-se algumas experiências relevantes, porém pontuais, com cinema na educação pública brasileira e também algumas questões que precisam ser pensadas para viabilizar a expansão dessa proposta nas demais escolas da rede pública de ensino.
COORDENAÇÃO PEDAGÓGICA EM TEMPOS DE CRISE NA EDUCAÇÃO ESCOLAR
Authors: PINHEIRO FERNANDES ELIANE
Published: September 2024

O presente texto versa sobre os desafios da atividade do coordenador pedagógico escolar, sobretudo como articulador da formação docente continuada em serviço. Tem como objetivo explicitar as relações entre a crise na educação e a reorganização do capital evidenciando que nem as dificuldades encontradas no cotidiano escolar para o desempenho da atividade pedagógica, nem os apelos à formação docente continuada são neutros. Tanto a precarização da educação pública (incluídos os cursos de formação inicial, as condições de trabalho, os problemas crônicos da educação básica) como as pretensas soluções ofertadas pelos empresários da educação tem suas raízes na agudização da crise estrutural do capital. Como consequência, a função essencial da coordenação pedagógica tem sido esvaziada e alienada.  Apresentamos como proposição a práxis do coordenador pedagógico da perspectiva da Trans-Formação que tem no imediato a busca por caminhos de superação por meio da luta por políticas públicas de defesa da educação básica totalmente estatal, da construção da práxis como prática-crítica orientada pela ciência da educação e, no horizonte, a emancipação humana.
Police forces struggle to tackle child sexual exploitation cases
Authors: Virdi Amrit
Published: September 2024

CYP Now investigation reveals poor handling of child sexual exploitation cases by police forces due to lack of joined-up working with other agencies and examines solutions to improve accountability and training
Hospital youth workers tackle risk factors
Authors: Józwiak Gabriella
Published: September 2024

Specialist support for young people attending A&E aims to reduce the risk of returning to emergency care, bringing down costs and potentially saving lives
It's not what you say, it's how you say it
Authors: Lewis Philip
Published: September 2024

Philip Lewis emphasises the importance of good communication for mouth cancer patients.
Displaced waste
Authors: Waters Rebecca
Published: September 2024

Rebecca Waters recommends sustainable solutions for waste management.
Handling complaints
Authors: Wake Charlotte
Published: September 2024

Charlotte Wake reviews how to best manage patient complaints.

Aim

To equip dental nurses with the knowledge to understand and effectively manage complaints in practice.

Objectives

To appreciate why patients may complain. For dental nurses to know where to seek help and support following a complaint.
Advancements and challenges in gastrointestinal imaging
Authors: Gong Eun Jeong , Bang Chang Seok
Published: September 2024

A recent review by Gulinac et al , provides an in-depth analysis of current clinical issues and challenges in gastrointestinal imaging. This editorial highlights the advancements in imaging techniques, including the integration of artificial intelligence and functional imaging modalities, and discusses the ongoing relevance of traditional nuclear medicine tests. The future of gastrointestinal imaging looks promising, with continuous improvements in resolution, enhanced ability to analyze color and texture beyond visual diagnosis, faster image processing, and the application of molecular imaging and nanoparticles expected to enhance diagnostic accuracy and clinical outcomes.
Early screening to identify and diagnose primary nasal tuberculosis in patients with tumor necrosis factor inhibitors
Authors: Shen Dan-Xiang , Wang Yu-Wei , Lin Zhi-Min , Jin Di , Ying Zhen-Hua , Li Chen
Published: September 2024

In this editorial, we comment on the article by Liu et al . Based on our analysis of a case report, we consider that early screening and recognition of primary nasal tuberculosis are crucial for patients undergoing treatment with tumor necrosis factor inhibitor (TNFi). While TNFi therapy increases the risk of reactivating latent tuberculosis, primary nasal tuberculosis remains rare due to the protective mechanisms of the nasal mucosa. Risk factors for primary nasal tuberculosis include minimally invasive nasal surgery, diabetes, and human immunodeficiency virus. Patients with early symptoms such as nasal congestion, rhinorrhea, altered olfaction, epistaxis, or ulceration, and unresponsive to conventional antibiotics and antihistamines should undergo early rhinoscopy, possibly followed by repeated tissue biopsies and acid-fast bacilli culture when necessary. When diagnosis is challenging, it is essential to consider local tuberculosis epidemiology and the efficacy of diagnostic anti-tuberculosis treatment. The preferred method for tuberculosis screening is the Interferon Gamma Release Assay, with a general recommendation for screening at 3 and 6 months after initial treatment and then every six months. However, the optimal frequency is not yet consensus-driven and may be increased in economically viable settings.
Journey to diagnosis: An unfinished exploration of IgG4-related sclerosing cholangitis
Authors: Liang Ming-Xing , Chen Ya , He Ya , He Yi-Huai
Published: September 2024

IgG4-related sclerosing cholangitis (IgG4-SC) is an inflammatory disease that leads to bile duct stricture, characterized by the infiltration of IgG4-positive plasma cells into the bile duct wall, thickening of the bile duct wall, and narrowing of the lumen. The differential diagnosis of IgG4-SC mainly includes primary sclerosing cholangitis, cholangiocarcinoma, and pancreatic cancer. IgG4-SC is often associated with autoimmune pancreatitis and can be accurately diagnosed based on clinical diagnostic criteria. However, isolated IgG4-SC is difficult to distinguish from biliary tumors. Given the significant differences in biological behavior, treatment, and prognosis between these diseases, accurately identifying isolated IgG4-SC has very important clinical significance.
Platelet-rich plasma treatment for chronic wounds: A case report and literature review
Authors: Dimova Ana , Boroš Martin , Dimov Stefan , Konjevod Janja , Svetec Maja
Published: September 2024

BACKGROUND

Wound healing is a complicated process that can be heavily influenced by patient comorbidities, in some cases leading to a chronic non-healing wound. Evidence presented in the medical literature supporting the clinical use of autologous platelet-rich plasma (PRP) in treatment of such wounds is becoming increasingly compelling. Mechanisms involved include complex interactions between the patient’s thrombocytes, cytokines, and growth factors.

CASE SUMMARY

We present a case of a 72-year-old male patient with a long-standing chronic wound and multiple comorbidities. Over the course of more than 7 months, the patient was unsuccessfully treated with all routinely used measures, including different dressing approaches. Multiple antibiotic regimens were administered for wound infection, with repeated evaluation of microbiological swab results. Finally, after three PRP applications, the wound showed clinical improvement with complete restitution of the epithelial layer of the skin.

CONCLUSION

PRP treatment may be beneficial to reduce healing time in chronic wounds.
Targeting nuclear factor erythroid 2-related factor 2-regulated ferroptosis to treat nervous system diseases
Authors: Huang Ye-Qi , Huang Zheng-Wei , Zhang Xue-Juan
Published: September 2024

By critically examining the work, we conducted a comprehensive bibliometric analysis on the role of nuclear factor erythroid 2-related factor 2 (NRF2) in nervous system diseases. We also proposed suggestions for future bibliometric studies, including the integration of multiple websites, analytical tools, and analytical approaches, The findings presented provide compelling evidence that ferroptosis is closely associated with the therapeutic challenges of nervous system diseases. Targeted modulation of NRF2 to regulate ferroptosis holds substantial potential for effectively treating these diseases. Future NRF2-related research should not only focus on discovering new drugs but also on designing rational drug delivery systems. In particular, nanocarriers offer substantial potential for facilitating the clinical translation of NRF2 research and addressing existing issues related to NRF2-related drugs.
Integrating the health belief model into health education programs in a clinical setting
Authors: Kam Bee Sung , Lee Sang Yeoup
Published: September 2024

The article demonstrates that health belief model (HBM)-based health education in hypertensive patients effectively improves blood pressure control and medication adherence at 3 months and 6 months. The HBM addresses perceived barriers, benefits, susceptibility, severity, and self-efficacy, leading to better health behaviors. HBM-based education has been effective in various contexts, including managing chronic diseases, promoting cancer screenings, and preventing infectious diseases. However, the model has limitations, such as cultural applicability and addressing complex health behaviors influenced by environmental factors. Future research should integrate HBM with other theories and conduct longitudinal studies to assess long-term impacts. Despite these limitations, HBM-based education significantly improves patient outcomes, highlighting its potential in health education and promotion when appropriately adapted and implemented. This reinforces the model's value in designing effective health interventions and advancing public health.
Visual consistency between display simulation and real scene observation: a case study for color preference assessment for illuminated scenes
Authors: Wu Xinwei , Chen Zhiyu , Liu Qiang
Published: September 2024

Display-based simulation has been widely adopted across various research fields, yet the visual consistency between this technique and real scene observation remains inadequately demonstrated. This study aimed to assess the feasibility of quantifying the color rendition performance of white light sources using display simulation. We examined the visual consistency through two psychophysical experiments conducted with the assistance of spectral imaging and color management. Two real-scene experiments, a rating experiment for fruits and a pair-comparison experiment for bronzeware within viewing light booths under various light sources, were accurately simulated on displays against different colored backgrounds. The results revealed overall significant and strong correlations between the color preference assessments in real and simulated scenes. The simulation deviation we observed could be attributed to chromatic adaptation and eliminated by controlling the interface background color. Meanwhile, the evaluation methods and the observers’ familiarity with the experimental objects might to some extent influence the evaluation results as well. By this study, the authors would like to highlight the crucial importance of accuracy in real scene replication for simulated reality.
Near-field enhancement of light by higher-order multipole excitations in a metal nanodisc trimer
Authors: Sehrawat Sagar , Shevchenko Andriy
Published: September 2024

Near-field enhancement of light by dipole excitations in plasmonic nanoparticles plays an important role in many applications of optical nanotechnology, including solar cells, plasmonic sensors, and nonlinear optical devices. Recently, we have shown that a seemingly weak octupole resonance in a pair of metal nanospheres can provide a higher near-field enhancement than the dipole resonance. Being motivated by this discovery, we now design a plasmonic nanodisc trimer that supports hybridized higher-order excitations and simultaneously suppresses the dipole excitation. We show that, under these conditions, the near-field enhancement can reach a high level, exceeding the value achievable with a corresponding dimer structure. The interference of the electric currents belonging to different multipole moments is found to play an important role in the enhancement. We believe that arrays of similar metal nanostructures can be designed to enhance optical fields via higher-order resonances for many applications, e.g., in nonlinear optics and optical sensing based on surface-enhanced fluorescence or Raman scattering.
Modeling analysis and error correction of dynamic angle measurement based on grating shear interferometry
Authors: Li Xiaohui , Xu Yongsen , Gao Wei , Yu Xiao , Shen Honghai , Cheng Yanping , Yang Ce , Liu Zewen , Zhang Linxia
Published: September 2024

This paper analyzes the principle of dynamic angle measurement using grating shearing interferometry (GSI), and derives a mathematical model for angle measurement and its maximum angular velocity limit. The study identifies that the increase in measurement error with the measurement angle in GSI systems is due to aberrations, which distort the period, position, and shape of the interference fringes. The source of measurement error is thus attributed to these aberrations. To address this issue, the paper proposes a method that uses the one-dimensional square-wave phase grating as diffractive beamsplitters and optimizes the system’s parameters. Simulation results demonstrated that this method corrects aberrations within a ± 20 mrad field of view (FOV) to the diffraction limit, thereby eliminating the aberration-induced measurement error. Experimental validation was performed using a fast steering mirror (FSM). When the angle of FSM is within ±10 mrad and its angular velocity is below 4.72 rad/s, the angular error of the optimized GSI measurement system can be within ±6µrad, and the measurement uncertainty is only 0.14 µrad. This method effectively addresses the problem of increasing GSI measurement error with angle, enabling high-precision dynamic angle measurement.
Height-resolved emission spectroscopy and high-speed imaging of the TiAl6V4 vapor plume under laser powder bed fusion conditions
Authors: Sprague Ethan , Busby Erik , Calta Nicholas P.
Published: September 2024

Optical emission spectroscopy is increasingly used as an in situ monitoring technique during laser powder bed fusion (LPBF) because plume emission holds elemental information not found in other in situ sensing techniques. This work explores the shape, stability, and temperature of the emission plume above the melt pool of Ti6Al4 V undergoing laser scans under LPBF-like processing conditions, using high-speed video and height-resolved spectroscopy to study the details of plume dynamics. Optical emission spectroscopy is conducted in the 480 nm to 525 nm region, where Ti emission is strong, with 0.3 mm vertical resolution above the baseplate. The Boltzmann plot method is used to determine temperature at each probed elevation, which indicates that the hottest location of the plume is occasionally elevated 0.3 mm to 0.6 mm above the scanning surface. The results show that the plume shape, stability, temperature, and spectra are highly dependent on the processing conditions. We highlight some of the complexities of optical emission spectroscopy and discuss potential challenges for implementing optical emission spectroscopy across an entire build.
Lensless light-field imaging using LMI
Authors: Mo Chen , Liu Xiaoli , Tong Jun , Xi Jiangtao , Yu Yanguang , Cai Zewei
Published: September 2024

Light-field imaging is widely used in many fields, such as computer vision, graphics, and microscopy imaging, to record high-dimensional light information for abundant visual perception. However, light-field imaging systems generally have high system complexity and limited resolution. Over the last decades, lensless imaging systems have attracted tremendous attention to alleviate the restrictions of lens-based architectures. Despite their advantages, lensless light-field imaging introduces significant errors in light-field reconstruction. This paper introduces a novel, to our knowledge, light field moment imaging-based lensless imaging system (LMI-LIS) aiming to improve the quality of light-field reconstruction. The proposed approach first uses light field moment imaging (LMI) with a sinc angular distribution model of the light field to extract the encoded information of the scene for each sub-aperture area. Meanwhile, the corresponding sub-aperture point spread function is segmented from the system point spread function. Finally, sub-aperture images of the scene are reconstructed separately for each sub-aperture area. To evaluate the light-field reconstruction performance, the imaging quality and angular consistency of different lensless light-filed imaging methods are compared through digital refocusing, epipolar plane image, peak signal-to-noise ratio, and structural similarity index. Furthermore, the effectiveness of the proposed methodology is verified using experimental results and theoretical analysis. It is demonstrated that lensless light-field imaging using LMI and the sinc model of the angular distribution achieves high-quality sub-aperture images.
Dynamic multiplexed intensity diffraction tomography using a spatiotemporal regularization-driven disorder-invariant multilayer perceptron
Authors: Luo Haixin , Chen Haiwen , Xu Jie , Wan Mingming , Zhong Liyun , Lu Xiaoxu , Tian Jindong
Published: September 2024

Multiplexed intensity diffraction tomography (mIDT) is a technique that reconstructs the three-dimensional refractive index (3DRI) of a sample solely through intensity measurements. Using an array of light sources to generate multi-directional and multiplexed illumination eliminates the need for mechanical scanning, allowing for quantitative 3DRI reconstruction of label-free samples. However, acquiring multiple images under different illumination conditions limits its use in dynamic scenes. Here, we propose a dynamic 3DRI reconstruction method based on a spatiotemporal regularization-driven disorder-invariant multilayer perceptron (STR-DI-MLP). This method reconstructs the 3DRI distribution of a sample from multiple images with motion-induced shifts. Simulations show it offers faster reconstruction speeds and fewer artifacts. Moreover, it maintains robust reconstruction performance under varying degrees of motion. Experimental validation of our system demonstrates its capability to reconstruct 3DRI in dynamic scenes with motion speeds below approximately 16 µm/s, proving it effective for 3DRI reconstruction of living microorganisms.
Ultra-low-complexity weight-sharing trigonometric nonlinear equalizer for beyond net-200-Gb/s/λ short-reach optical interconnects
Authors: Zhang Junwei , Tan Heyun , Li Fan , Lau Alan Pak Tao , Li Zhaohui , Lu Chao
Published: September 2024

An ultra-low-complexity third-order weight-sharing trigonometric nonlinear equalizer (WS-TNLE) is proposed to eliminate nonlinear signal distortions in short-reach optical interconnects exceeding net 200 Gb/s/λ. By replacing the second- and third-order nonlinear terms in a third-order weight-sharing diagonally pruned Volterra nonlinear equalizer (WS-DP-VNLE) with cosine and sine terms, respectively, the required number of real-valued multiplications per symbol of the proposed third-order WS-TNLE is significantly reduced to the same value as the number of weight-sharing kernels. When transmitting probabilistically shaped 16-level pulse amplitude modulation (PS-PAM-16) signals at net rates ranging from 200.4 Gb/s to 300.4 Gb/s over a 1-km standard single-mode fiber (SSMF), the proposed third-order WS-TNLE requires the lowest number of real-valued multiplications per symbol, ranging from 10 to 44, which reduces the computational complexity by up to 96.2% and 52.4% compared to the third-order WS-DP-VNLE and WS-DP-absolute-term nonlinear equalizer (WS-DP-ATNLE), respectively.
Flexible generation of azimuthally/radially polarized beams and hybrid polarized vortex beams using a thinned helical fiber grating
Authors: Meng Zhang , Zhao Hua , Jamy Jahidul Alam , Kotani Yuto , Wang Peng , Li Hongpu
Published: September 2024

An efficient method allowing the flexible generation of the azimuthally/radially polarized (AP/RP) beam and the hybrid polarized vortex (HPV) beam has been proposed and experimentally demonstrated by using a thinned helical fiber grating (T-HFG) with an intermediate period. This is the first time, to the best of our knowledge, that such three kinds of cylindrical vector beams can be flexibly generated by using only one fiber component. The proposed method provides the potential application of the HFG to not only the laser processing but also the optical manipulator and the optical tweezer.
Artifact-free crosstalk reduction in light field display based on multi-view image correlation
Authors: Lim Kyungmin , Jeon Kangwon , Lee Jaesung , Kim Daeyeong
Published: September 2024

Recently, 3D light field (LF) display technology is increasingly being applied for commercial products, as 3D representations are widely used in various fields such as game and metaverse applications. Inter-view crosstalk, which is caused by one or more unintended views being added to the intended view, is a major factor that induces image quality degradation and visual discomfort in 3D LF displays. In this paper, we propose an algorithm that provides optimal crosstalk reduction while preventing color over-shoot artifact that is common in conventional methods. The proposed algorithm applies an optimized crosstalk reduction filter, determined adaptively for every pixel in the image, based on the correlation between neighboring LF views. The experimental results using a LF display prototype show that the proposed method can reduce crosstalk effectively without causing color over-shoot artifacts and reduces crosstalk by 20.4% compared to the previous method.
Design and development of a high-power laser-driven multiple phosphor-converted white light source with a side-by-side configuration
Authors: Kumar Dheeraj , Varshney Ravi , Mehta Dalip
Published: September 2024

Phosphor-converted white light sources have become extremely popular because of their numerous applications and energy efficiency. Nevertheless, there are frequent issues with power, colour rendering indices (CRIs), lu-minous efficacy, and thermal management with the traditional design of these sources. In this study, we show the design and development of a high-power laser-driven multiple phosphor-converted white light source using a side-by-side configuration. The proposed design of a white light source with combinations of red‒green‒yellow phosphors generates white light with irradiation of 450 nm blue laser diode. The white light generated through the combination of these phosphors was analyzed in terms of its CRI, luminous efficacy, and spectral characteristics. The proposed design overcomes the shortcomings of traditional sources, offering improved power output, enhanced colour rendering capabilities, and efficient thermal management. The designed source has a photoluminance broad-emission spectrum ranging from 480-730 nm with a luminous value of 615 lux at 1.5 m in the forward direction at 45°. The developed design has CRI~80, colour temperature 5197 K (cool white light) and CIE1931 chromaticity coordinates (0.33, 0.34), which are very close to the proper white light chromaticity (0.33, 0.33). The source is less hazardous to human vision due to the lack of bright spots and uni-form illumination. The performance evaluation demonstrated the feasibility and efficacy of this approach, mak-ing it a promising illumination system for various lighting applications, such as PC-LD table lamps and auto-mobile PC-LD headlight structures.
Structure of the Nmd4-Upf1 complex supports conservation of the nonsense-mediated mRNA decay pathway between yeast and humans
Authors: Barbarin-Bocahu Irène , Ulryck Nathalie , Rigobert Amandine , Ruiz Gutierrez Nadia , Decourty Laurence , Raji Mouna , Garkhal Bhumika , Le Hir Hervé , Saveanu Cosmin , Graille Marc
Published: September 2024

The nonsense-mediated mRNA decay (NMD) pathway clears eukaryotic cells of mRNAs containing premature termination codons (PTCs) or normal stop codons located in specific contexts. It therefore plays an important role in gene expression regulation. The precise molecular mechanism of the NMD pathway has long been considered to differ substantially from yeast to metazoa, despite the involvement of universally conserved factors such as the central ATP-dependent RNA-helicase Upf1. Here, we describe the crystal structure of the yeast Upf1 bound to its recently identified but yet uncharacterized partner Nmd4, show that Nmd4 stimulates Upf1 ATPase activity and that this interaction contributes to the elimination of NMD substrates. We also demonstrate that a region of Nmd4 critical for the interaction with Upf1 in yeast is conserved in the metazoan SMG6 protein, another major NMD factor. We show that this conserved region is involved in the interaction of SMG6 with UPF1 and that mutations in this region affect the levels of endogenous human NMD substrates. Our results support the universal conservation of the NMD mechanism in eukaryotes.