bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Study of Colour Doppler versus Non Stress Test as a predictor of Perinatal outcome in PIH and IUGR
Authors: Singh Loutongbam Bishwajit , Goyal Bhupesh Kumar , Tangri Manoj Kumar , Singh Anil Kumar , Bhatt Reema Kumar
Published: January 2023

Background: Hypertensive disorders and intrauterine growth restriction are common complications encountered during pregnancy. This study was conducted to observe the usefulness of systolic/ diastolic (S/D) ratio in umbilical artery as compared with non-stress test (NST) to predict perinatal outcome in pregnancies complicated with hypertensive disorders and intrauterine growth restriction (IUGR).
Methods: It was a prospective observational which was conducted on patients undergoing antenatal visits at the department of obstetrics and gynaecology, Army hospital research and referral, New Delhi from May 2017 to April 2019. NST was started at 32 weeks twice weekly in all patients. All patients were subjected to umbilical artery Doppler velocimetry waveform on weekly basis or every third day in cases of nonreactive NST.
Results: Out of 140 patients, 53 patients (37.9%) had PIH and 44 (31.4%) had IUGR. 43 cases (30.7%) had both PIH and IUGR. Among the 140 patients, 40 patients (28.6%) had non-reactive NST and 60 patients (42.9%) of the patients had abnormal doppler. Abnormal doppler and non-reactive NST were associated with APGAR score of less than 7 at 5 minutes in the newborn. Abnormal perinatal outcome was more in abnormal doppler than normal doppler and the finding was statistically significant (p<0.05).
Conclusions: Overall sensitivity and diagnostic accuracy of Doppler is better as compared to that of NST in terms of detecting adverse perinatal outcomes.
Abdominal scar endometriosis-a dilemma in diagnosis
Authors: Singh Sonu , Shrivastav Ayushi
Published: January 2023

Abdominal scar endometriosis is a rare disease with an incidence of 0.03-0.15%. Its diagnosis is often confused with other conditions like hematoma, granuloma, diagnostic dilemmas, keloid, incisional hernia and vascular malformation. We are reporting two cases of abdominal scar endometriosis with some diagnostic confusion. In first case it was previously reported as stitch granuloma due to atypical clinical presentation. In second case CT scan was further reported it to be a likely neoplastic lesion. In both the cases, currently wide excision of the lesion with a safe margin was planned and confirmed by histopathology. On follow up both patients are asymptomatic.
Weight reduction and glycemic control in type 2 diabetes mellitus using a wholly Nigerian diet at university of Port Harcourt teaching hospital, Nigeria
Authors: Akoko Sokiprim , Iyeopu M. Siminialayi  , Sunday Chinenye
Published: January 2023

Background: Weight gain is associated with poor glycaemic control in patients with type 2 diabetes and worsened by resource restrained environment with almost no access to sustainable therapy. In the absence of effective access to health care and medication due to poverty, safer locally available and proven scientific options to manage their health becomes a priority. Today, targeted lifestyle interventions are found to be clinically effective and affordable for diabetes prevention and treatment. This study aimed to evaluate the efficacy of a wholly Nigerian diet in achieving weight reduction and good glycaemic control in patients with type 2 diabetes mellitus.
Methods: Sixty study participants were randomized into matched control (standard of care) and intervention (caloric restriction dietary intervention) groups. Participants were followed for 24 weeks and samples taken 3 times a week for the duration of the study.
Results: The result revealed a significant drop in weight (waist circumference and BMI) in the intervention group. Mean waist circumference decreased from 88.82 cm to 80.0 cm (p=0.001) while BMI decreased from 22.67 to 22.86 kg/m2 (p=0.025). The fasting blood sugar dropped from a group mean of 7.97 on the initial visit to a mean of 5.35 after six months in the intervention group.
Conclusions: Caloric restriction with locally available food reduced weight and normalized fasting blood sugar in study participants with type 2 diabetes mellitus.
Burden and features of neurological patients in Chittagong Medical College and Hospital in Bangladesh
Authors: Rahman M. Ridwanur , Farhana Zaman  , M. Hassanuzzaman  , Akramul Azam  , M. Mahabubul Alam Khandker  , Tasbeen Akhtar Sheekha
Published: January 2023

Background: Neurological disorders are a common and significant public health problem globally, and innovative strategies are needed to address the epidemic in resource-poor settings in Bangladesh. The aim of this study was to evaluate the burden and features of neurological diseases requiring hospitalization in a tertiary care hospital in Chittagong, Bangladesh.
Methods: This study was a prospective observational study conducted from January to June 2021 on patients admitted to the adult neurology unit of a hospital in Chittagong, Bangladesh. Data was collected through face-to-face interviews, laboratory data, and previous medical records, and in-hospital complications and outcomes were recorded. The data was cleaned and analysed using SPSS and presented in tables.
Results: In this study, stroke was the most common neurological condition requiring hospitalization, accounting for 74% of cases and leading to death in 73% of cases. The most frequent in-hospital complication was urinary tract infection (26%), mostly in stroke patients. Of stroke patients, 88% had incomplete recoveries at discharge, while 7% died. Hypertension was the most common risk factor present in both acute confusional state and stroke cases. The median duration of hospital stay was longest among patients with central nervous system infections.
Conclusions: Stroke dominates the burden of neurological diseases requiring hospitalization in tertiary care hospitals in Bangladesh. The most frequent in-hospital complication was urinary tract infections, mostly in stroke cases. The overall in-hospital mortality was 7%, most patients recovered incompletely at discharge (82%).
Evaluation of buprenorphine as an adjuvant to 2% lidocaine during intravenous regional anaesthesia
Authors: Yashoda Venkappa  , M. Paramesh Sanchara , Venkatesha Murthy Champa Banavara , Masamaddi Geetanjali
Published: January 2023

Background: Intravenous regional anaesthesia (IVRA) is a simple, effective method of anaesthesia for surgical procedures on the extremities. Major limitations are tourniquet pain, short duration of block and absence of post-operative analgesia. Buprenorphine is known to improve the quality of anaesthesia. Aim of this study is to evaluate the efficacy of buprenorphine as an adjuvant to lignocaine in IVRA.
Methods: Sixty patients between 18-60 years age, belonging to the ASA grade 1, 2 undergoing upper limb surgeries were enrolled into the study. Patients belonging to group BL patients received 10 ml of preservative free lidocaine 2% diluted to 40 ml. Group BB-patients received 10 ml of preservative free lidocaine 2% mixed with 60 mcg of buprenorphine diluted to 40 ml. Onset of sensory and motor block; recovery time and postoperative analgesia were noted. Data were analyzed using chi-square test, independent ‘t’ test.
Results: The onset time of both sensory and motor block were significantly shortened, the recovery of sensory and motor block was prolonged, the incidence of tourniquet pain was comparatively lesser and there was significantly increased duration of post-operative analgesia in the buprenorphine group. Haemo-dynamic parameters were similar in both groups
Conclusions: Sixty mcg buprenorphine as an adjuvant to lidocaine in IVRA effectively enhances the anaesthesia and post-operative analgesia.
Influence of maternal and child factors on the dental service utilization among preschool children in Bangalore urban district: a cross-sectional study
Authors: S. Sruthy , Puranik Manjunath P. , K. R. Sowmya
Published: January 2023

Background: Dental visit is considered primary marker of oral care. Maternal characteristics, attitudes and psychosocial factors and the child’s oral health may influence dental visits of preschool children. This study aimed to determine the influence of maternal and child factors on dental services utilization among preschool children.
Methods: A cross-sectional study was conducted among 600 preschool children and mothers visiting Anganwadis and Primary Health Centres in Bangalore Urban District. Mothers answered questions on socio-demographic characteristics and dental attendance. Maternal dental anxiety and child’s oral health-related quality of life were assessed using modified dental anxiety scale and early childhood oral health impact scale respectively. Oral health of children and mothers were assessed using WHO oral health assessment form 2013 for children and adults respectively. Descriptive statistics, Poisson’s regression with robust variance and mediation analysis were performed and p<0.05 was considered significant.
Results: The proportion of dental visit among preschool children was 13.5%. Majority of the mothers had high dental anxiety (76.2%) and perceived their children’s oral health-related quality of life to be good (71.2%). The caries experience in mothers and children were 63.5% and 54.2% respectively. Mothers with higher education (PR=2.05, p=0.037), caries experience (PR=3.17, p<0.001) and poor perception of child’s oral health-related quality of life (PR=5.88, p<0.001), and children with pain experience (PR=1.62, p=0.003) and decayed teeth (PR=1.81, p=0.017) influenced children’s dental visit. Maternal perception on child’s oral health-related quality of life mediates the relationship between child’s oral health and dental visit.
Conclusions: The utilization of dental services among preschool children was low. Maternal and child oral health factors influenced the child’s dental service utilization. Hence, oral health promotion approaches towards mothers and children is the need for the hour.
Distant delayed hypersensitivity reactions after taking spike protein containing adenoviral vector vaccine for COVID-19
Authors: Das Suchibrata , Barman Srutee , Roy Aritra , Patra Sangita
Published: January 2023

COVID-19 epidemic is still going on and various SARS-CoV-2 vaccines are available for emergency administration since December 2020. It has many side effects as other vaccines, but as it is a new vaccine, different side-effects are not well-known to us. Here, we are reporting one side-effect, appearance of distant delayed hypersensitive reaction lesions after covid vaccine.
Neuropsychiatric systemic lupus erythematosus: a rare case of acute polyneuropathy
Authors: Anand Aditya , Siddiqui Ammar S. , Singh Shivam , Basera Pragati
Published: January 2023

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease which presents most commonly in middle aged females and affects multiple organ systems. Amongst the many systems involved, the nervous system generally gets affected later in the course of the disease. We report a case of a male patient who developed quadriparesis as the initial presentation of SLE who progressed to lupus nephritis. The patient was started on methylprednisolone, and later planned on IVIg when he did not respond to the initial treatment. Unfortunately, the patient developed diaphragmatic paralysis and succumbed to the illness.
Two birds one stone-two rare cases of adenine phosphoribosyl transferase deficiency
Authors: Khan Mohammed Fahad , Siddini Vishwanath , Vankalakunti Mahesha , Ballal Sudarshan
Published: January 2023

Complete adenine phosphoribosyl transferase (APRT) deficiency is a rare inherited metabolic disorder that leads to the formation and hyperexcretion of 2,8-dihydroxyadenine (DHA) into urine. We had a 52-year-old male with Hypertension for 18 months, presented for routine evaluation and was found to have creatinine of 4.29 mg/dl. His urine analysis was done which showed no proteinuria or urinary sediments. His USG done demonstrated normal sized kidneys with mildly increased echogenicities. He underwent a renal Biopsy for etiology determination. Similarly, we had another case of a 54-year-old female with no comorbidities who was identified to have chronic kidney disease in 2018 with a baseline creatinine of 2 mg/dl came with uremic symptoms and history of NSAID intake in June 2019. Her creatinine peaked to 7.9 mg/dl. Urine analysis displayed 1+ proteinuria with no active sediments. Her USG of the kidneys showed normal kidneys with increased echogenicities. She underwent renal biopsy for etiology determination. Biopsy of case 1 showed chronic interstitial nephritis and case 2 showed acute interstitial nephritis. Both biopsies showed deposition of 2,8-dihydroxyadenine crystals. Genetic analysis of both cases showed an exon mutation in chromosome 16.
Rheumatoid arthritis-associated interstitial lung disease seen in two generation of females in an Indian family
Authors: Shah Arti D. , Patel Kaushani H. , Naik Parshwa , Chakravarti Chirag H.
Published: January 2023

Interstitial lung diseases (ILDs) or diffuse parenchymal lung diseases (DPLDs) are a group of lung diseases that is distinguished by subacute or chronic inflammation and/or fibrosis. Family history is currently being considered one of the biggest risk factors for ILD. Rheumatoid arthritis (RA) a systemic autoimmune disease has lungs as its most common extraarticular organ involved. Interstitial lung disease associated with it is one of the major causes of mortality along with severe disability. Lung involvement in RA might appear as ILD, pleural effusion, or pulmonary vasculitis. In this case report a 42-year-old female presented with complain of progressive breathlessness, dry cough, chest pain, joint pain since past 10 years. HRCT Thorax of patient suggested it to be ILD of UIP pattern with raised RF, anti CCP and positivity in ANA profile. Patient had a family history with mother being diagnosed with ILD-NSIP pattern. She was suspicioned for RA as she had complained of small joint pains and swellings and was responding well to steroids and HCQ.
Dentinogenesis imperfecta type 1-Shield’s classification (1973): a rare case report and literature review
Authors: K. Saraswathi Gopal , V. Poogodi , S. Priyadharshini
Published: January 2023

Dentinogenesis imperfecta (DI) is an autosomal dominant disorder that affects the dentin development. It is characterized by the presence of opalescent dentin, with dusky blue to brownish discoloration of the teeth. This condition is genetically and clinically heterogeneous; DI may affect only the teeth or it may be associated with the osteogenesis imperfect (OI). When both are associated there are various degrees of clinical presentation from mild form with less significant signs to severe form such as death in infancy. The most familiar classification system of this hereditary disorder is Shields classification which is of 3 types namely, type I, DI associated with OI, type II is not associated with OI. Type III which is also known as ‘Brandywine type’ DI.  This case report describes a rare case of 32-year-old female patient who showed the characteristic features of Shield’s classification type I with penetrance of defect through 4 generations.
A participação das micro e pequenas empresas de Porto Alegre e Região Metropolitana no Programa de Agentes Locais de Inovação do Sebrae: uma pesquisa de campo
Authors: Silva Rafael Mozart da , Nunes Anderson de Souza
Published: January 2023

As micro e pequenas empresas (MPEs) são importantes para o desenvolvimento econômico e social no Brasil, especialmente para a geração de empregos. O Serviço Brasileiro de Apoio às Micro e Pequenas Empresas (SEBRAE), desde 2008, atua com os Agentes Locais de Inovação (ALI) com objetivo de disponibilizar a temática inovação aos pequenos negócios no Brasil. Nesse sentido, a presente pesquisa tem como objetivo geral apresentar os resultados relacionados as ações implementadas em 245 MPES localizadas em Porto Alegre e região metropolitana, as quais foram atendidas durante o Ciclo 1 do Projeto ALI. A metodologia de pesquisa se classifica quanto a natureza como aplicada, em relação a abordagem como qualitativa e quantitativa e quanto aos objetivos pode ser classificada como exploratória e descritiva. O procedimento técnico utilizado é pesquisa de campo, realizada por dezessete Agentes Locais de Inovação (ALIs) que fazem parte da equipe da região metropolitana do projeto. Constata-se uma diversidade no conjunto das empresas participantes, sendo 81 do setor de comércio, 31 da indústria e 133 de serviços. A partir da aplicação e do diagnóstico realizado através do Radar de Inovação (RI) junto as MPEs e das ações propostas e implementadas, registra-se uma evolução de 10,15% no conjunto das seis dimensões propostas pelo RI. Ao analisar o indicador de produtividade das MPEs participantes do projeto, verifica-se que houve uma evolução de 39,33%, o que demonstra a efetividade das ações propostas e a importância das participações das empresas no junto ao Projeto ALI do Sebrae.
Disonancia intrínseca de las matemáticas: el caso del crédito ‘gota a gota’
Authors: Alvis-Puentes Johnny Fernando , Trujillo Alarcón Edna Rocio , Sarmiento Rivera Dermin Rogelio
Published: January 2023

El presente documento, pretende describir y analizar una situación de riesgo actual, que devela de manera amplia un ejemplo de los argumentos teóricos presentados por Ole Skovsmose, sobre la disonancia intrínseca de las matemáticas en relación con el desarrollo de la democracia. La situación de riesgo, se relaciona con un sistema informal de crédito que utiliza gran parte de los ciudadanos de estratos socioeconómicos bajos en el territorio colombiano. Se analiza como las matemáticas operan como un salvavidas a muchas necesidades humanas diarias, pero que, en manos de personas que anteponen los fines de lucro individual, origina que se agudice la crisis social de ciertos grupos de ciudadanos. Por lo anterior, se hace la necesidad de una alfabetización matemática que conduzca a establecer y vislumbrar la forma en que las matemáticas estructuran las sociedades actuales.
Uma abordagem filosófica sobre a noção de sujeito na psicologia de Skinner
Authors: Castro Marina Souto Lopes Bezerra de
Published: January 2023

Fazendo jus à obra do professor Abib, pretende-se neste ensaio apresentar de forma crítica um de seus textos: O sujeito no labirinto, de 2007. Veremos como a noção de sujeito aparece na obra de Skinner a partir de filosofias e psicologias precursoras do Behaviorismo Radical. A irônica afirmação pós-moderna da morte do sujeito revela, na verdade, uma pro­funda mudança na ideia que se tem de sujeito. Ao longo de seu texto, Abib descreve ques­tionamentos desde Hume a alguns aspectos da visão metafísica do sujeito e mostra como as filosofias e psicologias modernas já sinalizavam a recusa ao sujeito metafísico, transcendente, substancialista e dualista. Ao percorrer grandes autores, Abib nos presenteia com densas informações e análises surpreendentes, por vezes inusitadas, ao seu estilo. Passa por diferen­tes noções de sujeito (processo volitivo-afetivo-ideativo em Wundt, fluxo da consciência em James, consciência social em Mead) até chegar a Skinner. Ao final, percebe-se uma coerência da construção moderna do sujeito com a sentença pós-moderna de sua morte. Entendemos, de fato, que aquele sujeito pré-moderno (metafísico, transcendente, substancialista e dua­lista) sofreu duros golpes e agonizou ao longo da modernidade, até que a pós-modernidade anunciou o seu fim. Contudo, não é o fim do sujeito, mas daquele sujeito pré-moderno. Abib resgata e reconstroi uma noção de sujeito coerente com as propostas dos grandes autores aqui citados, desembocando na psicologia de Skinner: temos um sujeito fenomenal, imanente à experiência, não-substancialista, não-dualista e não-metafísico.
Por uma história filosófica do Comportamentalismo
Authors: Lopes Carlos Eduardo , Laurenti Carolina
Published: January 2023

Examinamos neste artigo a arrojada tese defendida por Abib no ensaio “O que é Comportamentalismo?”, qual seja, a de que a história do Comportamentalismo começa com Skinner, e não com Watson. Para explicitar seus argumentos, apresentamos, inicialmente, a forma de trabalho intertextual de Abib, pautada em uma interpelação filosófica e cultu­ral do texto psicológico. Com base nesse método, Abib delineia uma história filosófica do Comportamentalismo, descortinando os compromissos epistemológicos e metafísicos das teorias do comportamento de J. B. Watson, E. C. Tolman e B. F. Skinner. O resultado dessa investigação conceitual mostra que apenas a teoria de Skinner é capaz de realizar o sentido originário da proposta de psicologia comportamentalista, que é explicar os fenômenos psi­cológicos no comportamento. Destacamos algumas vantagens da história filosófica de Abib sobre outras versões da história do Comportamentalismo, e concluímos que sua análise ar­queológica fornece ferramentas heurísticas profícuas para nos ajudar no debate sobre pro­postas comportamentais contemporâneas.
PLANEJAMENTO URBANO E A POLÍTICA HABITACIONAL EM MACAPÁ
Authors: Tostes José Alberto , Tavares Ana Paula Cunha
Published: January 2023

Compreender a dinâmica habitacional da cidade de Macapá pressupõe a análise de seu processo histórico de planejamento urbano. A densidade urbana e habitacional do estado do Amapá e de sua capital está diretamente relacionada às políticas regionais implantadas. Em razão disso, surgiram as iniciativas públicas para a construção de conjuntos habitacionais visando responder às demandas da população por moradia e infraestrutura básica com expressivas intervenções. O método de análise foi o lógico-histórico e dialético para confrontar as contradições sobre a política habitacional. A metodologia utilizada foi a análise de trabalhos científicos já produzidos sobre o tema e documentos oficiais e os projetos dos empreendimentos de habitação de interesse social. Os objetivos do artigo visam discutir como a implantação de políticas habitacionais em Macapá, a partir do programa “Minha Casa Minha Vida” do governo federal, impactaram a estrutura urbana de Macapá e a melhoria de vida da população local, destacando o caso de análise do Conjunto Açucena, concluído em 2018. A relevância do tema é demonstrar os contrapontos de projetos habitacionais de interesse social a partir da visão da Nova Agenda Urbana.
NOVOS TERRITÓRIOS DO MORAR EM CIDADES PEQUENAS
Authors: Oliveira Joanna Célia Rodrigues , Pereira Cláudio Smalley Soares
Published: January 2023

O presente artigo analisa os novos territórios do morar em cidades pequenas. Parte-se do pressuposto de que as transformações contemporâneas do capitalismo redefiniram o papel das cidades e suas estruturas urbanas. Nesse bojo, os espaços de moradia foram transformados e as dinâmicas econômicas, sociais e espaciais da reestruturação do capital pavimentaram a expansão de novas formas do morar para cidades de distintos tamanhos e complexidades. Casa Nova, na Bahia, é o centro urbano que será o foco deste trabalho. Busca-se revelar as transformações do espaço urbano e o modo como a estruturação espacial, associada aos imperativos do capital em termos de novos espaços de moradia, se expressa nesta cidade em termos de processos de autossegregação. Os espaços residenciais fechados, atualmente, configuram, assim, uma nova forma-conteúdo da moradia presente, também, em cidades pequenas.
Mapas de Desarrollo Tecnológico en Centros de Investigación y Desarrollo Universitarios
Authors: Valdés-Rodríguez Miriam , López-Ortega Eugenio , Castillo-Camarena Nadia
Published: January 2023

Los mapas de desarrollo tecnológico (MDT) son una herramienta que apoya la planeación estratégica en las organizaciones, principalmente en la fase de implementación. Por ello, pueden ser útiles para la planeación de Centros de Investigación y Desarrollo Tecnológicos Universitarios (CIyDT-U). Sin embargo, los MDT enfrentan desafíos con respecto a la incertidumbre asociada a los cambios internos y externos que presenta una organización en su proceso de implementación.

Se presenta una propuesta metodológica sustentada en el concepto de atractores, que permitiría a un CIyDT-U identificar los cambios de su entorno para realizar los ajustes pertinentes en las acciones requeridas para construir y/o fortalecer sus competencias y lograr el estado futuro deseado.

Además, de la experiencia de los Centros universitarios analizados se observa que los indicadores de su desempeño se identifican por unidad administrativa, mientras que la aplicación de MDT requiere que se consideren por separado cada tema de investigación.
Komodifikasi Agama dalam Layanan Aqiqah di Akun Instagram @aqiqahnurulhayat
Authors: Darojatun Rina , Mukarom Zaenal , Muhibuddin Muhibuddin
Published: January 2023

Artikel ini fokus pada transformasi pesan agama menjadi produk jasa yang dapat dipasarkan melalui instagram, objek kajiannya adalah pesan-pesan yang mengandung komodifikasi layanan aqiqah, khalayak virtual yang berinterakasi di akun @aqiqahnurulhayat dan mitra layanan aqiqah yang bekerja menggiring khalayak untuk menggunakan jasa layanan aqiqah. Penelitian ini merupakan penelitian kualitatif, dilakukan dengan metode etnografi virtual diawali dengan memasuki arena media social Instagram lalu capturing chatlog dan capturing screenshots dan menganalisis data dari entitas. Hasil penelitian ini mengungkapkan terjadinya komodifikasi agama melalui tiga hal yaitu komodifikasi isi pesan, komodifikasi khalayak virtual dan komodifikasi mitra layanan jasa aqiqah, ketiganya nampak dari gambar dan pesan yang diposting di akun @aqiqahnurulhayat sudah mengalami adaptasi ajaran agama dengan pesatnya teknologi digital yang menggeser gaya hidup muslim kelas menengah dalam merayakan kehadiran anak di tengah keluarga.
Genesis and World Chronology
Authors: Walton John
Published: January 2023

Distrust of Genesis as history has been fostered by uniformitarian geoscience and Deep Time chronology.   The reality or otherwise of a global flood has a crucial bearing on world history and chronology.  Evidence of disparate kinds favouring such a flood from scripture, from geoscience and from anthropology is presented. Radiocarbon dating, suitably calibrated for the flood discontinuity, substantiates a Compact Time chronology of thousands of years for earth history.  This is reinforced by comparison of flood model radiocarbon dates for ancient near eastern sites with those independently obtained by archaeologists. Further corroboration of the Genesis chronology comes from discoveries of preserved soft tissues, proteins and even DNA in fossil dinosaur bones and in other specimens from throughout the geologic column.   Belief in a recent, rapid creation is credibly defensible by science divested of secular naturalist ideological constructs. Compact Time chronology rehabilitates belief in the historical reality of the Genesis accounts of the origin of life and the origin of death.
CERENERLAL REMODELING AFTER CRANIO-BRAIN INJURY IN HIGH MOUNTAINS
Authors: Shidakov Y. H.-M , Zhanuzakov D. Z , Shuvalova M. S
Published: January 2023

The article discusses the presentation of the features of cerebellar remodeling after traumatic brain injury (TBI) in the highlands. The experiment was carried out on 106 outbred male rats weighing 210-290 g in compliance with the rules of laboratory practice. In high-altitude conditions, in contrast to low-altitude conditions, significant changes occur in the cerebellum, namely, changes in the membrane potential of cells, ectopia of Purkinje cells, pronounced changes in molecular and granular layers.
APPLICATION EXPERIENCE OF THE STRESSPROTECTIVE BINAURAL INFLUENCE METHOD IN ETIOPATOGENETIC CORRECTION OF BRUXISM IN DENTAL PRACTICE
Authors: Ageeva Yu. V , Klauchek A. E , Parkhomenko A. N , Klauchek S. V , Shemonaev V. I , Bazovaya M. V , Mecericyan K. A
Published: January 2023

The article presents the data of a complex dental and neurophysiological examination of young people with parafunctional activity of the masticatory muscles (bruxism). The effectiveness of stress-protective lateral heterosuggestion technique in the etiological and pathogenetic correction of bruxism and the possibility of its use in dental practice have been proven.
CARDIOVASCULAR EFFECTS OF CHEMIO- AND RADIATION THERAPY I N CANC E R PAT IEN TS : WHAT A CARDIO-ONCOLOGIST SHOULD KNOW PART II)
Authors: Bespalov V. G , Kirakozov D. A , Ilyukhin O. V
Published: January 2023

In the second part of the review, the analysis of modern literature data demonstrating the pathophysiological mechanisms of the development of cardiovascular complications of chemo- and radiation therapy in oncological patients should be continued.
AN T I M I C RO B I AL EFFICACY OF MILD PERIODONTITIS INITIAL THERAPY IN PATIENTS WITH DIABETES MELLITUS TYPE II WITH DIFFERENT DURATION OF ENDOCRINE DISEASE
Authors: Mihalchenko V. F , Patrusheva M. S , Mihalchenko A. V , Kraynov S. V. , Gharty Chetry S. , Pogosyan A. A
Published: January 2023

Endocrine pathology, including diabetes mellitus, significantly affects the immune response characteristics to microbial invasion and, as a result, the microbial balance of the oral cavity in normal conditions and in periodontal diseases. The aim of the study was to evaluate the antimicrobial efficacy of mild periodontitis nonsurgical treatment in patients with type II diabetes mellitus with different duration of endocrine disease. It is shown that before the start of therapy, in dependance of endocrine pathology duration, the bacterial flora of periodontal pockets in the groups was different. The standard therapy also demonstrated varying degrees of effectiveness, and on the background of positive response to the treatment in both groups, the trend to normalization of the microflora in patients with newly diagnosed diabetes mellitus was more evident.
PHARMACOECONOMIC ANALYSIS OF THERAPY REGIMENS FOR AGGRESSIVE 79 LYMPHOMA AND HODGKIN LYMPHOMA
Authors: Petrov V. I , Kaplanov K. D , Shatalova O. V
Published: January 2023

The registration of new drugs significantly expands the possibilities of hematologists and oncologists in the treatment of tumors of lymphoid tissue. The cost of new monoclonal antibodies, inhibitors of various signaling pathways and immune checkpoints disproportionately exceeds the direct cost of "classical" programs of combined cytostatic therapy. The regimens included in the National Clinical Guidelines remain the basis of first-line therapy, are combined with new agents, and are the standards of comparison of treatment efficacy for new agents. Regional population registries can be a source of useful information on the quantities of basic first- and subsequent-line cytostatic agents needed and the size of the financial costs of providing therapy to patients with hemoblastosis.
INDICATIONS AND RESULTS OF PREVENTIVE MINIMALLY INVASIVE SURGICAL DECOMPRESSION IN INTRAPERITONEAL HYPERTENSION IN PATIENTS WITH STERILE PANCREATIC NECROSIS WITH CARDIAC AND PULMONARY COMORBIDITY
Authors: Klimovich I. N , Maskin S. S , Shevcov M. N , Golbrah V. A , Arutiunian A. G
Published: January 2023

Resume. Intra-abdominal hypertension (IBH) in patients with sterile pancreatic necrosis (SP) leads to the formation of abdominal compartment syndrome (ACS) in 6-8 96. The most vulnerable in this regard are patients with cardiac and pulmonary comorbidity (CLC). Difficulties in predicting the development of ACS in most cases do not allow making a timely decision on surgical decompression, which leads to delayed surgical treatment and associated high mortality. Objective: to develop and conduct a clinical evaluation of a method for determining indications for preventive minimally invasive surgical decompression in IBH in patients with SP with cardiac and pulmonary comorbidity. Materials and methods. Prospective cohort studies were performed in 84 patients with sterile pancreatic necrosis with CLC, of which 40 patients were in the main group and 44 in the comparison group. Results and discussion. IBH I-II art. was formed in the main group in 32 (80 %) patients, in the comparison group in 34 (77 %). In 10 (29,4 %) patients from group for comparison, ACS developed, while in all 5 (5/22 - 22,7 %) patients with IBH of the first art., it was not possible to diagnose the syndrome in vivo. Categorically, it became possible to verify ACS only in 5 (5/12 - 41,6 %) patients with type II IBH, however, delayed surgical decompression in 60 % (3 out of 5) cases led to mortality. In the main group of patients with SP with CLC, the developed method for determining indications for preventive surgical decompression in IBH I-II art., allowed to prevent the development of ACS in 34 % (11 out of 32) patients, to reduce the number of intraoperative complications by 43 %, and the minimally invasive variant of operations reduced the number of early postoperative complications by 75 %. Conclusions. The developed method for determining indications for preventive minimally invasive surgical decompression in patients with SP with CLC allowed to reduce the mortality associated with an increase in intra-abdominal pressure by more than 2 times, and the overall mortality by 5,5 %.
THE EFFECT OF MELATONIN ON THE DYNAMICS OF BODY WEIGHT AND THE LEVEL OF KLOTHO PROTEIN IN THE BLOOD OF ANIMALS WITH PREMATURE AGINGCAUSED BY DARK DEPRIVATION
Authors:   Volgograd State Medical University, Kondakova L.I. , Bagmetova V.V. ,   Volgograd State Medical University, Sirotenko V.S. ,   Volgograd State Medical University, Donika A.D. ,   Volgograd State Medical University
Published: January 2023

On the model of premature aging induced by 30-day dark deprivation (light-dark cycle 24/0 h, artificial illumination 300 Lux), the effect of exogenous melatonin (0.3 mg/kg, 14 days after the cancellation of dark deprivation, intragastric dailyin 2 % starch mucus) on the dynamics of body weight and the level of Klotho protein in the blood was studied in outbred white male rats of 4 months of age. It has been shown that prolonged dark deprivation is accompanied by a statistically significantdecrease in the content of the Klotho protein in the blood serum, which is a marker of premature aging. Metabolic disorders associated with a statistically significant decrease in the level of melatonin and Klotho protein in the blood were expressedin fluctuations in the dynamics and rate of body weight gain in animals. At the same time, exogenous melatonin had a protective effect on the condition of animals –it contributed to an increase in the content of Klotho protein in the blood serum and restoredthe level of melatonin to the values of the negative control indicator.
PHYSICAL DEVELOPMENTAND GENERAL CONDITION OF THE OFFERINGSFROM FEMALE RATS WITH NUTRITIONAL HYOPMAGNESIA
Authors:   Volgograd Medical Research Center for Innovative Medicines with Pilot Production,, Korzhova T.M. ,   Volgograd Medical Research Center, Bugaeva L.I. ,   Volgograd Medical Research Center for Innovative Medicines with Pilot Production,,   Volgograd Medical Research Center, Lebedeva S.A. ,   Volgograd Medical Research Center for Innovative Medicines with Pilot Production,,   Volgograd Medical Research Center, Getmanenko A.Yu. ,   Volgograd Medical Research Center for Innovative Medicines with Pilot Production,,   Volgograd Medical Research Center, Spasov A.A. ,   Volgograd Medical Research Center for Innovative Medicines with Pilot Production,,   Volgograd Medical Research Center
Published: January 2023

The article presents the results of a study on the effect of alimentary hypomagnesemia of varying severityinpregnant female rats on the physical development and condition of their offspring. The experiments were carried out on offspring born from female rats that were on a magnesium-deficient diet for 2 and 4 months until the moment of conception. After this time, the magnesium level in blood plasma and erythrocytes was determined. With adecrease in the nutrient in plasma from 0.7 mmol/l and in erythrocytes from 1.7 mmol/l of rats, females were mated with intact males. After birth, the offspringwere assessed: survival, general condition, body weight gain, physical development and the formation of sensory-motor reflexes.It has been established that alimentary hypomagnesemia of varying severity in female rats negatively affects the general conditionand physical development of their offspring.
MORPHOFUNCTIONAL CHANGES IN RAT TESTES DURING PREMATURE AGING CAUSED BY DARK DEPRIVATION
Authors:   Volgograd State Medical University, Kondakova L.I. , Kalashnikova S.A. ,   Volgograd State Medical University, Polyakova L.V. ,   Volgograd State Medical University, Bukatin M.V. ,   Volgograd State Medical University
Published: January 2023

The rapid development of technology has a significant impact on the daily life of a person. Light, sound, information pollution leads to sleep disturbance, which has a negative impact on the physical condition. Even short-term sleep disturbance caused by dark deprivation leads to a decrease in serum testosterone levels. The imbalance of male sex hormones, the synthesis of which is under the control of the hypothalamic-pituitary system, negatively affects the morphofunctional state of the testes. The effect of exogenous melatonin on the morphological and functional state of the spermatogenic epithelium of the testes, Leydig cells in white outbred male rats of 4 months of age was studied on the model of premature aging caused by 30-day dark deprivation, and the Klotho protein level in blood serum was assessed by enzyme immunoassay. It was found that the morphological changes in the testes were characterized by a decrease in the thickness of the spermatogenic epithelium by 30 days after darkdeprivation and a decrease in the level of the Klotho protein, which is a marker of premature aging. The introduction of exogenous melatonin had a protective effect on the morphological and functional status of the testes of animals, accompanied by the restorationof the spermatogenic epithelium, an increase in the Klotho protein to the level of thenegative control group
THE VALUE OF PERIPHERAL BLOOD NK CELLSAND EXPRESSION OF TRANSFORMING GROWTH FACTOR BETA-1 IN RECURRENT OVARIANENDOMETRIOSIS
Authors:   I.I. Mechnikov Northwestern State Medical University, Petrovskaya Nicole N. , Pechenikova Victoria A. ,   I.I. Mechnikov Northwestern State Medical University
Published: January 2023

Affiliation.Federal state budgetary educational institution of higher education «North-Western State Medical University named after I. I. Mechnikov» under the Ministry of Health of the Russian Federation, Saint-PetersburgIntroduction.Elevated level of transforming growth factor-β1 (TGF-β1) can be the cause of impaired immune response among women with endometriosis due to its ability to reduce the activity of NK-cells, which contributes to the survival of ectopic endometrial cells in the abdominal cavity and plays a key role in the progression of the disease.Materials and methods.196 endometrioma observations were studied, an immunological study of peripheral blood was performed with the determination of CD3-CD16/56+(natural killers) and an IHC study of the expression of TGF-β1 in the capsuleof an endometrioid cyst and in a preserved cytogenic stroma. Results.The IHC study showed that the expression area of TGF-β1 was significantly larger in the surgical material in the recurrent course of endometriosis; an immunological study revealed a significant decrease in NKcells during the endo-metrioma recurrence.Conclusion:Further study of the relationship between TGF-β1 and NK cells may be important as prognostic markers of recurrent endometriosis.
PROBLEMS OF ERADICATION THERAPY AND WAYSTO OVERCOME THEM: REVIEW OF MODERN RECOMMENDATIONS AND REAL PRACTICE
Authors:   Volgograd State Medical University, Petrov V.I. , Ponomareva A.V. ,   Volgograd State Medical University, Ivakhnenko I.V. ,   Volgograd State Medical University, Razvalyaeva O.V. ,   Volgograd State Medical University, Dotsenko A.M. ,   Volgograd State Medical University
Published: January 2023

Helicobacter pyloriinfection remains the leading cause of a number of gastroduodenal diseases. Although various eradication regimens are used to reduce associated morbidity and mortality, the prevalence of this bacterial infection is still disproportionately high worldwide, mainly due to antibiotic resistance. In these conditions, it is very important to strictly follow the basic recommendations for choosing an eradication therapy scheme. This article provides an overview of current Russian and international consensus guidelines and recommendations for the treatment of helicobacter infection. The resultsofvarious studies, including our own, are presented to assess the compliance of real practice in the management of patients with Helicobacter pyloriinfection with current clinical recommendations.
CHANGES IN FUNDUS AUTOFLUORESCENCE IN YOUNG SUBJECTS WITH DIFFERENT TYPESOF REFRACTION. REPORT 1
Authors:   Volgograd State Medical University, Gndoyan I.A. , Petraevsky A.V. ,   Volgograd State Medical University, Dyatchina A.I. ,   Volgograd State Medical University, Klimentov P.O. ,   Volgograd State Medical University
Published: January 2023

Purpose:to assess the state of the macular region of the retina using the study of autofluorescence (AF) of theeye fundus in young subjects with high visual acuity and different types of clinical refraction.Material and methods.104 healthy volunteers (208 eyes), 70 females and 34 males, aged 20 to 30 years, average age (24,5± 0,4) годаy.о., were examined. All patients had high visual acuity (1,0 and higher) and there were no signs of pathology in the macular region, which was established ophthalmoscopically and confirmed by optical coherence tomography (OCT) data. Such methods of the examination were performed in all subjects as visometry with correction, refractometry, ophthalmobiomi-ocroscopy with Goldmann's lens, OCT in the 3D mode of the macular region of the fundus and the study of fundus-AF with typing on known patterns: normal pattern, minimal changes, focal changes and reticular pattern. The analysis was carried outin10 subgroups depending on the type, the degree of clinical refraction and the presence of astigmatism.Results.4 main patterns of AF were identified in the examined subjects: normal, minimal changes, focal changes and reticular. The most common pattern in all refractive groups was the reticular pattern, the frequency of which ranged from 41,7 to 88,9%. The least common pattern was normal, the frequency of which ranged from 4,2 to 33,3%. A significant differencebetween the values of the thickness of the retina in the foveal zone with the reticular pattern and its average group value in different refractive groups was not found.Conclusion.In young subjects with high visual acuity without clinical manifestation of pathology of the macular zone, AF-patterns other than the normal picture may be present. The reticular pattern is noted as the most common in all analyzed groups with various types of refraction. Further studies of early changes in fundus AF may make it possible to determine thepredictors of the development of dystrophic pathology of the macular zone.
FEATURES OF ADAPTATION OF YOUNG PEOPLE TO NEW ENVIRONMENTAL CONDITIONS WHEN CHANGING THE PLACE OF RESIDENCE
Authors:   Military Medical Academy named after S.M. Kirova, Mulik A.B. ,   Scientific and Clinical Center of Toxicology named after S.N. Golikov, Doletsky A.N. ,   Volgograd State Medical University, Yusupov V.V. ,   Military Medical Academy named after S.M. Kirova, Postnova M.V. ,   Volgograd State Medical University, Ulesikova I.V. ,   Military Medical Academy named after S.M. Kirova, Nazarov N.O. ,   Clinical Hospital No 5, Volgograd, Kobryanova I.V. ,   Military Medical Academy named after S.M. Kirova, Shatyr Yu.A. ,   Volgograd State University,
Published: January 2023

The purpose of the work was to identify patterns of adaptation of young people to new environmental conditions when changing their place of residence. The study was carried out from September 2021 to June 2022, with the participation of134 people, 32 men and 102 women aged 18–20, first-year students of state universities in Volgograd. The gender, age, place of birth and place of residence of the respondents before entering the university were taken into account. To assess the level of systemic maladjustment, in terms of psychological, psychophysiological and psychosomatic symptoms of extreme tension of the body, a blank test by I.N. Gurvich, developed at the Psychoneurological Research Institute. V.M. Ankylosing spondylitis in1992. Manifestations of a stress reaction (Giessen questionnaire of somatic complaints) and anxiety-depressive disorders (HADS scale) were taken into account, and the presence of suicidal ideation was determined –modulo suicidal ideas of the Columbian Suicidal Seriousness Scale (C-SSRS). The functional status, in relation to the stress resistance of the subjects, was assessed by the level of the general nonspecific reactivity of the organism. As a result of the studies performed, it was determined that the maximum development of systemic maladjustment, at the time of passing the second examination session, is characteristic of male students who arrived to study in Volgograd from other regions of Russia. Throughout the spectrum of the studied symptoms of disa-daptation, both in the somatic (headaches, pains in the stomach, heart, abdomen) and in the mental (insomnia, physical fatigue, depression, suicidal ideation) sphere, their prevalence in groups of non-indigenous students is characteristic. residents of the Volgograd region, which is especially pronounced in men. In addition, male students, representatives of other regionsofRussia are characterized by a high level of general non-specific reactivity, indicating their low stress resistance, and men –the natives of the Volgograd region, in general, are characterized by an averagelevel of general non-specific reactivity of the organism.Women –participants in the study, both indigenous and non-indigenous residents of the Volgograd region, are characterized by a high level of non-specific reactivity, which implies an increasedstress reactivity of the body, and, accordingly,a risk of systemic maladaptation.