bluuebunny/crossref_metadata_2025 huggingface dataset:
IN SILICO DESIGN, SYNTHESIS AND EVALUATION OF IN VITRO GLUCOSE UPTAKE, GENE EXPRESSION, AND α-GLUCOSIDASE INHIBITORY ACTIVITY OF NOVEL 2-AMINOBENZIMIDAZOLE DERIVATIVES
Authors: SREEJA S  , ANTON SMITH A  , MATHAN S
Published: December 2019

Objective: The present study was aimed to design and evaluate the antidiabetic potential of novel 2-aminobenzimidazole derivatives by in silico method.

Materials and Methods: Various in silico tools such as Chemsketch, Molinspiration, Prediction of activity spectra for substances, OpenBabel, Discovery Studio was used in the designing and evaluation of the biological activity. The retrieved hits were further filtered by absorption, distribution, metabolism, and excretion descriptors. The designed molecules having required physicochemical properties, drug-likeness, and obeying Lipinski’s rule of five were selected for the synthesis. The synthesized compounds were subjected to determination of yield, melting point and characterized by infrared, 1HNMR, 13CNMR, and mass spectroscopic methods. The selected derivatives were subjected to in vitro glucose uptake, 50% lethal dose (LD50) determination, gene expression analysis, and α-glucosidase inhibitory assay.

Results: Totally, 32 novel analogs of 2-aminobenzimidazole were designed and 17 compounds were selected for docking analysis; and finally, five derivatives (3a, 3c, 3e, 3f, and 3h) were selected for synthesis. Among them, the compounds 3a and 3f were selected for in vitro glucose uptake analysis. Finally, the compound 3f was selected for LD50 determination, gene expression analysis, and α-glucosidase inhibitory assay. The selected derivative 3f showed a significant α-glucosidase inhibitory activity compared with the standard drug acarbose.

Conclusion: These results are useful for further investigation in the future, and hopefully, these studies could discover a new specific leads in antidiabetic category as α-glucosidase inhibitor.
PHYTOCHEMICAL SCREENING AND ANTIOXIDANT POTENTIAL OF ANACARDIUM OCCIDENTALE, ACHYRANTHES ASPERA, AND AEGLE MARMELOS
Authors: BRIJYOG  , LALITESHWAR PRATAP SINGH  , SUSHIL KUMAR  , SHWETA VERMA
Published: December 2019

Objective: Anacardium occidentale, Achyranthes aspera, and Aegle marmelos are the common plants found in North and South India. The present study identifies the active phytochemicals and antioxidant properties in various extracts derived from dried bark, whole aerial parts, and leaves of the above plants.

Materials and Methods: Phytochemical screening included extracts of pet ether, hydroalcoholic, and aqueous. The antioxidant activity was determined by measuring total phenolic contents (TPC), 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging activity (RSA), and total flavonoid content (TFC).

Results: The phytochemical screening of A. occidentale, A. aspera, and A. marmelos of dried bark, whole aerial parts, and leaves revealed the presence of flavonoids, phenols, tannins, and proteins. It also contains alkaloids and glycosides. Hydroalcoholic extract of A. occidentale, A. aspera, and A. marmelos showed highest TPC 0.125 mg/g, 0.256 mg/g, and 0.254 mg/g, respectively. TFCs 0.094 mg/g, 0.145 mg/g, and 0.121 mg/g and highest DPPH RSA with the half maximal inhibitory concentration of 125 μg/mL, 105.58 μg/mL, and 98.89 μg/mL compare to the standard ascorbic acid of 21.65 μg/mL.

Conclusion: This study showed that the hydroalcoholic extract of A. occidentale, A. aspera, and A. marmelos is potential source of natural antioxidants.
APPLICATION OF CENTRAL COMPOSITE DESIGN AND RESPONSE SURFACE METHODOLOGY FOR OPTIMIZATION OF METAL ORGANIC FRAMEWORK: NOVEL CARRIER FOR DRUG DELIVERY
Authors: PREETI KUSH  , JITENDER MADAN  , PARVEEN KUMAR
Published: December 2019

Objective: The aim of the present study is to optimize the synthesis method of metal-organic framework (MOF) for high yield and larger surface area with minimum size for efficient drug loading.

Materials and Methods: Materials of Institute Lavoisier (MIL)-101-NH2 was synthesized by microwave-assisted hydrothermal method. Central composite design (CCD) under response surface methodology (RSM) was used for optimization. Process optimization was done by validating the model to obtain maximum surface area, maximum yield, and minimum particle size. Final obtained formulation was characterized by particle size and zeta potential, scanning electron microscopy, powder X-ray diffraction, Fourier-transform infrared spectroscopy, Brunauer–Emmett–Teller, and thermogravimetric analysis. Furthermore, gemcitabine (GEM) was used as a model drug for encapsulation in these MOFs for drug delivery carriers.

Results: The results revealed that MIL-101-NH2 of average size-158 nm with high yield (70%) and high surface area (2347 m2/g) could be produced easily and reproducibly at a selected condition. This enhances the drug delivery application of the valuable MIL-101-NH2. Optimized values for these parameters were 170°C, 5.00, and 1:1:400 for temperature, pH, and reactant ratio, respectively. MIL-101-NH2 appeared as a promising carrier for GEM delivery with higher encapsulation (77.7±2%) and loading (22.6±2%).

Conclusion: The results conclude that processing parameters such as temperature pH and reactant concentration obtained from CCD-RSM significantly affect the main constraints, i.e., surface area, particle size, and yield. The faster encapsulation of GEM in MOF makes them a promising carrier for drug delivery application.
SPECTROPHOTOMETRIC DETERMINATION OF TOTAL PHENOLIC CONTENT FOR STANDARDIZATION OF VARIOUS PHYLLANTHUS SPECIES
Authors: Rakhi Khabiya
Published: December 2019

Objective: This study aims at comparison of total phenolic content of ethanolic extract of various species of Phyllanthus available in Gujarat state by spectrophotometric method.

Methods : The total phenolic content was determined quantitatively using the Folin Ciocalteu reagent, with Gallic acid as standard.

Results: The total phenolic content in methanolic extract of various Phyllanthus species  ranged from 41.801 to 87.542 mg/g of dry weight of extract, expressed as gallic acid equivalents. Phyllanthus urinaria was found to have highest phenolic content and Phyllanthus acidus  was found to have lowest phenolic content .

Conclusion: The total phenolic content will be helpful for developing new drugs and standardizing the various Phyllanthus species particularly morphological similar species. The presence of a high total phenolic content shows that the alcoholic extract of Phyllanthus may possess antioxidant properties, which could lead to a new field of research in the future.
SMARTPHONE ADDICTION AND ITS RELATIONSHIP WITH PSYCHOLOGICAL HEALTH AMONG STUDENTS OF A MEDICAL SCHOOL IN EAST COAST MALAYSIA
Authors: AZWANIS ABDUL HADI  , HAWARI MUSYIR MOHD NAWAWI  , NURAFIFAH SHAMSURI  , NURUL NAJIHAH RAHIM  , HAFIZAH PASI
Published: December 2019

Objective: Smartphones have now become a common and almost essential tool in our daily living activities. Students are among those who use smartphones regularly, which could lead to addiction if overused. This study aims to measure the prevalence of smartphone addiction and its relationship with psychological health among clinical year medical students in International Islamic University Malaysia (IIUM), Kuantan.

Methods: A total of 226 medical students in their clinical years were recruited through quota sampling method. The students filled in a four-part online-based questionnaire consisted of questions on sociodemographic characteristics, smartphone usage information, smartphone addiction scale-short version, and WHOQOL-BREF. Data were analyzed using IBM SPSS Statistics.

Results: The prevalence of smartphone addiction among clinical year medical students in IIUM was 51%. Bivariate analysis showed that the majority of students chose social networking as their primary purpose of using a smartphone, and this was significantly associated with smartphone addiction (p=0.037). Following multiple logistic regression analysis, students who had chosen games as their primary purpose of smartphone users are 88% less likely to be related with smartphone addiction (p=0.009, 95% CI: 0.025–0.595) as compared to those who used it for academic performance tasks. Students who were not addicted to smartphones reported significantly better psychological quality of life compared to those who were addicted (p<0.001).

Conclusion: Half of IIUM’s medical students in clinical years was found to have smartphone addiction, and those with smartphone addiction had poor psychological health. Immediate intervention such as creating awareness in the campus is important in curbing this problem.
Исследование влияния элементов конструкции ИК объектива на величину теплового фонового потока, падающего на матрицу фотоприемников
Authors: Правдивцев А.В.
Published: December 2019

Чувствительность тепловизионных и теплопеленгационных станций, используемых для сбора спектрально-­топологической информации, ограничена паразитными фоновыми засветками, попадающими на матрицу приемников излучения. В статье рассматривается влияние конструкции оправ оптических элементов в ИК‑объективе, предназначенном для работы в диапазоне 8–12 мкм, на величину внутреннего и внешнего паразитного фонового излучения. Оптимизация конструкции оправ позволяет минимизировать паразитные засветки и обеспечивает высокие эксплуатационные характеристики оптико-­электронной системы, в состав которой входит ИК‑объектив. В работе определены элементы конструкции, вносящие наибольший вклад в суммарный фоновый поток и оптимизирована их структура с помощью созданной цифровой модели. Рассмотрено влияние процесса охлаждения элементов конструкции на величину собственного фонового потока.
Амплитудный волоконно-оптический датчик вибрации
Authors: Бурдышева О.В. , Никулин И.Л.
Published: December 2019

Волоконно-оптические датчики вибрации имеют ряд неоспоримых преимуществ перед электрическими датчиками при работе рядом с действующими электрогенераторами или в условиях повышенной взрывобезопасности. Принцип работы амплитудного волоконно- оптического датчика вибрации основан на нарушении закона полного внутреннего отражения. В статье описана концепция датчика вибрации, приведены результаты экспериментальных исследований прототипа.
Фотонные и радиофотонные приложения: перспективы рынка InP-пластин
Authors: Догмус Е. , Лин Хонг
Published: December 2019

Технологии фотоники – ​телекоммуникации, устройства передачи данных, лидары, датчики – ​стали источником роста и развития современного рынка пластин из фосфида индия. Производство перспективных полупроводниковых приборов для фотонных и радиофотонных применений требует использования эпитаксиальных и InP-пластин. Подобные подложки обеспечивают переход технологий приемопередающих устройств к более высоким скоростям передачи данных. По прогнозам аналитиков компании Yole Dйveloppement (Yole), за 2018–2024 годы рынок InP-пластин возрастет до 172 миллионов долларов, увеличиваясь со среднегодовыми темпами прироста в 14% в значениях Compound Annual Growth Rate (CAGR).
Особенности эксплуатации станка для микрофрезерования крупногабаритных плоских оптических деталей
Authors: Захаревич Е.М. , Лапшин В.В. , Ложкарев В.В.
Published: December 2019

В статье представлены основные конструктивные особенности станка для м микрофрезерования крупногабаритных плоских оптических деталей. Описан технологический процесс и особенности обработки. Приведены результаты обработки
крупногабаритных изделий из алюминиевого сплава АМг6 и водорастворимого кристалла KDP.
Проблемы проведения измерений облученности в процессе лазерной обработки металлов
Authors: Крючина О.А. , Садовников И.Э.
Published: December 2019

Реализованный в дозиметре метод контроля облученности от рассеянного и отраженного лазерного излучения в процессе лазерной обработки металлов подразумевает измерения облученности пространства рабочего места оператора только в процессах с неподвижным пучком. Современные лазерные технологии базируются на высокоскоростных движениях лазерных пучков, оттого ранее разработанные методы контроля параметров лазерной облученности требуют принципиально новых подходов к методам дозиметрического контроля. В статье представлены данные об особенностях проведения измерений облученности отраженного и рассеянного лазерного излучения при обработке металлов подвижным лазерным пучком и рассматриваются возможные пути решения возникших проблем.
Лазерное упрочнение сталей прямоугольным пятном для повышения ресурса их работы
Authors: Бирюков В.П. , Шмелев С.А. , Богданов А.В. , Тасканц М.В. , Штамм В.Г. , Успенский С.А.
Published: December 2019

Стремительное развитие источников лазерного излучения и внешних оптических систем требует совершенствования методов расчета геометрических параметров упрочненных зон. В работе представлен краткий обзор по лазерному упрочнению сталей лазерным пятном прямоугольной формы. Приведены результаты расчета глубины и ширины упрочненных зон колесной стали лазерным пятном прямоугольной формы, полученные по уравнениям регрессии первого порядка, при равной погонной энергии излучения. Показано, что при лазерном упрочнении на различных режимах износостойкость колесной стали повышается в 2,14–3 раза, при этом снижается изнашивание рельсовой стали.
Лидарные технологии: современное состояние и перспективы
Authors: Кожина Е.П.
Published: December 2019

Лидарные технологии зондирования удаленных объектов, основанные на явлениях рассеяния и поглощения света в прозрачных и полупрозрачных средах, развиваются в течение нескольких десятилетий. Современные лидары стали основой множества инструментов машинного видения, картографирования, диагностики атмосферы и удаленных объектов различной прирды. В заметке представлен краткий обзор некоторых актуальных направлений использования лидарных технологий, выполненный по материалам открытой печати.
Применение газовой хромато-масс-спектрометрии для диагностики заболеваний надпочечников (обзор литературы)
Authors: Малеваная Е.В. , Стрельникова Е.Г. , Зыбина Н.Н.
Published: December 2019

Возможность определения конечных и промежуточных продуктов стероидогенеза делает хроматографические методы анализа, особенно хромато-масс-спектрометрию, наиболее ценными в комплексной диагностике заболеваний гипофизарно-­адреналовой системы. В обзоре описаны различные стратегии пробоподготовки биологических образцов перед проведением анализа методом газовой хромато-масс-спектрометрии (ГХ-МС). Рассмотрены стадии ферментативного гидролиза, экстракции и дериватизации. Вторая часть посвящена клиническому применению метода ГХ-МС для диагностики различных форм эндогенного гиперкортизолизма, адренокортикального рака, врожденной дисфункции коры надпочечников и ферментативных нарушений метаболизма стероидов.
Tres días que conmovieron al mundo: panorama de las ciencias sociales (1989-2016)
Authors: Vera Héctor
Published: December 2019

Este artículo reflexiona sobre cambios visibles —y algunas tendencias ocultas— en las ciencias sociales desde el fin de la Guerra Fría hasta la segunda década del siglo XXI. Se toman como puntos de articulación tres eventos geopolíticos y las respectivas inquietudes intelectuales que se han producido en este campo de conocimiento. Primero, la caída del Muro de Berlín y lo que fue conocido como el “fin de la historia”. Segundo, la destrucción de las Torres Gemelas en los ataques terroristas en Manhattan y lo que llamaron el “choque de civilizaciones”. Tercero, el referéndum del Brexit y la elección de Donald Trump a la presidencia de Estados Unidos, que conllevó al surgimiento de un “populismo antiglobalista”. De cada uno de estos tres episodios propongo una lección para mejorar nuestras prácticas contemporáneas en nuestras disciplinas.
El marxismo: una evaluación de la crítica y el discurso ante la caída del Muro de Berlín
Authors: Fuentes Diana
Published: December 2019

Bajo la consideración de que el marxismo constituye por sí mismo una historia intelectual y sociopolítica que presenta múltiples variantes, entre las que ha habido incontables debates, opositores y detractores, que visibilizan la enorme complejidad de pensamiento que deriva de la crítica de la economía política de Marx, en el presente trabajo se trazan algunas líneas de demarcación para el estudio del pensamiento marxista antes y después del derrumbe del Muro de Berlín. El centro de este esbozo parte de la consideración de la centralidad de la trayectoria de aquellas formas del discurso que renovaron el núcleo crítico de Marx en una franca oposición al marxismo dogmático y mecanicista del socialismo soviético, y que, a treinta años del derrumbe del socialismo soviético, son las que con mayor persistencia han permitido insistir en la vigencia de su criticidad, en su capacidad explicativa del mundo contemporáneo y en la necesidad de volver a pensar en una modernidad no capitalista.
Significado y alcance del Muro en el siglo XX. La resurgencia de una triple centralidad europea
Authors: Sberro Stéphan
Published: December 2019

En esta contribución, analizaré las consecuencias de la caída del Muro desde la perspectiva de las relaciones internacionales y en particular desde la geopolítica. Explicaremos cómo, después de la caída del muro, Europa —que era un continente dividido entre dos potencias y que no era dueña de su destino— regresó a una triple centralidad. Entre 1989 y 1992, Alemania volvió a ocupar el centro geográfico y político de Europa mientras la Unión Europea se perfila de nuevo como un polo de poder no solamente económico sino también diplomático y financiero (con el euro). Insistiremos en particular sobre el desarrollo seguido, pasado por alto por los internacionalistas, respecto al renacimiento de la noción de Europa central como idea tanto histórica como cultural, con un real sentido político e influencia dentro del nuevo proyecto europeo y en particular de sus relaciones con el Este (Rusia) y el Sur (el Medio Oriente). A su vez, este renacimiento de Europa central es una de las manifestaciones de la reemergencia de varios imperios (ruso, chino, otomano) que juntos con el declive de Estados Unidos contribuyen al advenimiento de un mundo multipolar.
Formulation and Evaluation of Anti-Acne Face Wash Gel using Guava Seed Extract
Authors: Kamble Manish , Selwate Tejaswini , Dhabarde Disha , Ingole Ashwini , Baheti Jagdish
Published: December 2019

During the puberty, imbalance of internal constituents and hormonal balance may cause many skin problems. Acne is found as most common skin problem. Face and neck are the major affected area. Preventive approaches involve removal of oil from the face. Proper cleaning and washing require for this purpose. Various researches have been proved utility of herbal based formulations for cleaning purpose which also removes excess oil; considering this fact present work was intended to prepare a face wash gel using Psidium guajava seed extract with antioxidant and antibacterial properties. Prepared gel was evaluated for various quality control parameters like; spreadability, pH, consistency and grittiness, etc. The results of quality control parameters were found to be satisfactory.

Keywords: Acne, Gel, Antimicrobial, Psidium guajava, Face-wash
Intervention and Mechanism of Dexmedetomidine on A549 Cells Injured by Hypoxia/Reoxygenation
Authors: Gao Hui , Luo Ziyin , Zhou Zhuolin , Wu Yiming , Wang Wantie
Published: December 2019

Objective: To investigate the effect and mechanism of dexmedetomidine (DEX) on hypoxia /reoxygenation (H/R) injury of A549 cells.

Methods: A549 cells were cultured and randomly divided into four groups (n=10): Normoxic group;DEX group; H/R injury group;H/R injury+DEX intervention group. Observe the morphological changes of cells; Cell viability was detected by cck-8 assay. TUNEL assay was used to detect apoptosis index (AI).Expressions of GRP78, CHOP, JNK, caspase-12, caspase-3 proteins and mRNA were detected by Western Blot and RT-PCR;Detect the activity of caspase-3.

Results: Compared with the H group, the OD value and AI value in the HD group were significantly up-regulated, apoptotic cells were significantly decreased, the expressions of CHOP, caspase-12, p-JNK and caspase-3 proteins and mRNA were significantly decreased, the GRP78 protein and mRNA increased, and the caspase-3 activity was significantly decreased, the differences were statistically significant (P<0.01).

Conclusion: Dexmedetomidine has a protective effect on A549 cells after H/R injury, which may be related to its inhibition of apoptosis induced by excessive endoplasmic reticulm stress.

Keywords: Dexmedetomidine; Hypoxia/Reoxygenationinjury;Apoptosis;Endoplasmicreticulm stress.
Solubility Enhancment of Azithromycin by Solid Dispersion Method by using Polymer PVP K 90
Authors: Zinjad Sanchay S , Udmale Devyani A , Suryawanshi Akshada D , Jadhav S. L. , Gaikwad D.D.
Published: December 2019

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Therapeutic Management of Pulmonary Tuberculosis by Mannosylated Chitosan Ascorbate Microspheres: Preparation and Characterization
Authors: Bagre Archana , Lariya Narendra Kumar , Kori Mohan Lal
Published: December 2019

Objective: In this study, biodegradable Chitosan Ascorbate Microsphere (CAMs) and mannosylated chitosan ascorbate microsphere (m-CAMs) prepared for targeting towards alveolar macrophages to treatment of pulmonary tuberculosis. 

Significance: Ascorbic acid is an antioxidant and reported killing effect on mycobacterium by induces fenton reaction. This study enlightens the possible benefits of adding antioxidant properties of ascorbic acid with chitosan microsphere to an anti-tuberculosis regimen and mannosylation of microsphere significantly induce the targetability of antitubercular drug to alveolar macrophages.

Methods: CAMs prepared by firstly salification of chitosan by ascorbic acid then ionic gelation with STPP and m-CAMs prepared by incubation method and purified for further studies. The physicochemical, in vitro and in vivo characterizations of both formulations were carried out.

Results: The size of microspheres (both CAMs and m-CAMs) were found to be in range of 3.40-4.81µm. Evident changes were observed in crystallinity and structure of both carrier systems and depicted by Fourier transform infrared (FTIR), Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) studies. In vitro lung deposition study of microspheres showed favourable aerodynamic properties for deep lung delivery (MMAD 2.0- 3.8 μm) and, thus, show potential for an application as inhalable tuberculosis therapy. The drug release showed the biphasic pattern of release, i.e., initial burst (30-45% up to 8 h) followed by a slower sustained release pattern (more than 80% up to 72 h) in both simulated lung fluids. Optimized formulations exhibited lower cytotoxicity and bio distribution studies demonstrated the efficiency of m-CAMs for spatial delivery of INH to alveolar tissues. CAMs and m-CAMs evidenced minor cytotoxicity on lung epithelial cells (A549 cell lines).

Conclusion: m-CAMs thus has a promising potential to be explore as an effective carrier system for delivery of antitubercular drugs regimen.

Key words: Targetability, alveolar macrophage, lung cancer A549 cells
Development of Extended Release Formulations of Ilaprazole Tablets
Authors: Divya B. , Sreekanth J. , Satyavati D.
Published: December 2019

Extended release products are designed to release their medication in a controlled manner at a predetermined rate, duration, and location to achieve and maintain optimum therapeutic blood levels of a drug. The objective of the study is to formulate and evaluate Ilaprazole Controlled release tablets comparable to the innovator product. F1-F9 formulations were prepared using varying concentrations of super disintegrates like Crospovidone, Croscarmellose sodium and Sodium starch glycolate in different concentrations. Based on the hardness, friability, weight variation, drug content, F6 formulation was found to be optimised. The selected F6 formulation was sub coated with HPMC P 50 and followed by enteric coating with Acryl-EZE-80 (Eudragit L100-55). 3 formulations (F10-F12) were prepared by using coating. Among the three formulations, F11 formulation was found to be best. FTIR studies were carried out to find out drug and excipient compatibility studies, the studies revealed that there were no interactions. DSC studies also carried out to demonstrate any changes in physical forms of the drug molecule.

Keywords: Ilaprazole, Extended release tablets, Crospovidone, Croscarmellose sodium, Sodium starch glycolate, HPMC P 50, Acryl-EZE-80.
BISCUIT FORMULATION WITH SUBSTITUTION OF BROWN RICE FLOUR
Authors: Widodo Slamet , Sirajuddin Saifuddin
Published: December 2019

Focus of this study was formulation of biscuit with substitutionof  brown rice flour which were widely accepted by the community. The objective of the study was to formulate biscuit subtitution by brown rice flour. The experiment was conducted in Maret-July 2017 in Family Welfare Education Laboratory. Data collected was quality of biscuit (color, flavor, texture, taste, and overall) and the preference. Data was analyzed by Mean and ANOVA. Result: 18g wheat flour, 6g cornstarch, 4g tapioca starch, 19g brown rice flour, 12g margarine, 29g eggs yolk, and 12g refined sugar. Nutrition contents the best biscuit was water 2,52g, ash 1,19g, fat 24,46g, protein 11,68g, carbohydrate 60,15g, and energy 507,46Kcal.
A Teoria de Resposta ao Item Aplicada em Avaliações da Educação Profissional e Tecnológica: uma revisão sistemática da literatura
Authors: Korb Thiago , Andrade Dalton Francisco de , Freire Patrícia De Sá
Published: December 2019

A avaliação da educação profissional é uma lacuna, não havendo sistema de avaliação nacional e nem metodologia consolidada que atendam suas particularidades. Este artigo tem como objetivo identificar quais experiências de aplicação da Teoria de Resposta ao Item (TRI) na avaliação da educação profissional já foram pesquisadas e registradas cientificamente. A metodologia utilizada foi a Revisão Sistemática da Literatura (RSL). Após análise na base de dados Scopus, foram escolhidos cinco artigos que configuram a amostra final deste estudo. Os artigos selecionados são relativamente recentes (todos a partir do ano 2000) e relatam experiências internacionais sobre o problema de pesquisa. Constatou-se que algumas iniciativas foram implementadas nesse intuito, contudo ainda são pouco exploradas, demonstrando a necessidade de pesquisas científicas para aprofundamento e instrumentos de avaliação com viés prático para aferição das competências profissionais.
Project-research activity in Russian language lessons for 5th-graders in studying lexis on the example of the topic “Homonyms”
Authors: Vasilieva Margarita I.
Published: December 2019

The relevance of the research is justified by the necessity of developing methodical basis for project-research activity at the lessons of the Russian language at schools. The article is aimed at: 1) giving justification for introducing project-research activity into in-class work while studying the section “Lexis” in the 5th forms by approving the methods given by the author for studying the topic “Homonyms”; 2) evaluating the development of general learning skills (comparing, giving definitions for terms, giving arguments for a point) using the material of the topic ‘Homonyms”; 3) assessing the knowledge of Russian lexis of pupils from control and experimental classes, comparing the results; 4) specifying the term “project-research activity” in the aspect of the goals of Russian language learning in middle school. The theoretical relevance of the article is in providing justification for identifying project-research activity as a specific separate type of learning activity, specifying the term “projectresearch activity” in Russian language classes in the middle school, specifying general learning skills (comparing, giving definitions to terms, giving arguments for a point) necessary for conducting projectresearch activity in Russian language classes, providing description for the levels of their development on the example of studying the “Homonyms” topic in 5th grades. The practical relevance of the article is in giving developed and proven program that includes pupils’ work on researching project “Portrait of the word” in the 5th form during studying the section “Lexis”. This article discusses the possibilities of studying vocabulary at Russian language classes using project-research activity. Project-research activity in Russian language classes is understood as independent cognitive activities of the pupils, aimed at studying the Russian language, developing linguistic knowledge and skills and forming general studying capabilities. This type of activity is characterized by having a project idea, it is planned as a process of achieving the project idea through consequent research operations. The author proposes the program for studying the topic “Homonyms” within the framework of “Portrait of the word” project, and the results achieved during experimental education are discussed. The data obtained during experimental education allow making a conclusion that project-research activity can be effectively integrated into class-and-lesson system of studying vocabulary in Russian classes in the 5th form: it promotes forming knowledge and skills on the topic and general learning skills of comparing, giving definitions for terms and giving arguments for a point. The directions of future research are in developing methods of organizing project-research activity in Russian language classes both during lessons and in extracurricular activity on the material of topics ‘Morphology”, “Syntax”, “Phonetics”, etc.
PERUBAHAN HISTOPATOLOGI MIDGUT LARVA An. vagus (DIPTERA : CULICIDAE) AKIBAT PAPARAN EKSTRAK BIJI PINANG (Areca catechu L).
Authors: Mading Majematang
Published: December 2019

Anopheles mosquitoes is main vector of malaria and filariasis. The use of bioinsecticide is an alternative way to reduce the negative impacts of synthetic insecticide. Areca catechu L. seeds contain secondary metabolites that have bioinsectisidal effects. The aim of this study was to analyze the effects of A.catechu L. seed extract on An. vagus larvae midgut. This study was a laboratory experimental research that designed as post test only control group design. A.catechu L. seed from Southwest Sumba Regency was extracted using ultrasonic methods. Larvae used in this study were Anopheles vagus instar III or early IV that devided into seven groups of the extract concetration (500; 1250; 2000; 2750; 3500; 4250 and 5000 ppm) and control group to find out the toxicity of the extract. Each group consists of twenty five larvae. The histopathology of larval midgut was stained with Hematoxyllin-Eosin and observed using light microscopy 24 hours after exposure. Histopathological examination of larval midgut showed the mild, moderate and severe damages on larval midgut after 24 hours exposure. Areca catechu L. seed extract can lead to changes in damage larval midgut. Areca catechu L. seed extract can be recommended to be used effectively as a natural larvicidal mosquito control program.
MODEL PENDEKATAN MULTISEKTOR UNTUK PENINGKATAN STATUS GIZI IBU DAN ANAK ETNIS MOLO DI KABUPATEN TIMOR TENGAH SELATAN
Authors: Aimanah Ira Ummu , Budisuari Made Asri , Machfutra Eka Denis
Published: December 2019

Status gizi merupakan faktor penting bagi pertumbuhan balita yang berpengaruh terhadap tingkat kecerdasan. Namun, etnis Molo di Desa Fatumnasi, Timur Tengah Selatan (TTS), masih menjalankan adat taskon yang berpotensi menurunkan tingkat kesehatan ibu dan anak. Adat taskon merupakan serangkaian kegiatan bertujuan merawat ibu selama masa nifas yaitu pantangan terhadap makanan selama 40 hari dengan hanya memakan jagung bose, yang mempengaruhi pemenuhan gizi ibu dan anak. Penelitian ini bertujuan memahami mengapa dan bagaimana masyarakat etnis Molo melaksanakan taskon dan menyusun model intervensi peningkatan status gizi ibu dan anak Etnis Molo. Penelitian ini menggunakan metode kualitatif deskriptif dengan wawancara mendalam terhadap ibu nifas, tokoh agama dan tokoh masyarakat etnis Molo pada April-Oktober 2017. Hasil menunjukkan taskon masih banyak dilakukan Marga Oematan, walaupun kini hanya dilakukan 4-8 hari pertama kelahiran. Adat ini turun temurun masih dilakukan karena masyarakat takut jika melanggar bisa mengalami sakit bahkan mengakibatkan kematian. Hasil observasi menggambarkan kondisi vegetasi Desa Fatumnasi dataran tinggi subur tetapi sedikit penduduk yang memanfaatkan potensi tersebut. Akses transportasi dan infrastruktur kurang mendukung dalam memasarkan hasil perkebunan. Mengatasi gizi buruk tidak bisa dilakukan sektor kesehatan sendiri, tetapi sektor lain yang terkait yaitu pertanian, peternakan dan kesehatan hewan. Model intervensi multisektor diharapkan bisa menekan kasus gizi buruk.
O ESPAÇO GEOGRÁFICO PARA ALÉM DE SUAS MATERIALIDADES: MEMÓRIA, TRADIÇÃO E O SABER FAZER DOS ALIMENTOS
Authors: Menezes Sônia De Souza Mendonça , Mendes Geisa Flores
Published: December 2019

O presente artigo tem o propósito de suscitar questões e apresentar temáticas de pesquisa que conduzam à reflexão acerca da inevitável vinculação entre o espaço geográfico e a memória social considerando como uma vertente significativa de análise a produção e consumo de alimentos e seu viés identitário. Partimos do princípio que a referência espacial é condição sine qua nom para que uma memória seja evocada, bem como os alimentos consumidos e transformados em territorialidade são essenciais para a reprodução da vida dos homens e mulheres. Tal compreensão tem possibilitado a realização de pesquisas geográficas com temáticas instigantes, pois a concretude que marca a configuração do espaço está eivada também de simbologias e subjetividades presentes nas práticas cotidianas que nele se desenrolam.
Impact of excess cash on earnings management and firm value: Evidence from China
Authors: Thenmozhi Muthuveerappan , Saravanan Palanisamy , Sasidharan Aghila
Published: December 2019

This study examines how excess cash drives earnings management and firm value in China. Using a fixed effect panel regression on a sample of 12,629 observations covering 300 firms listed in the Shanghai Stock Exchange, we find that excess cash has a positive impact on firm value confirming pecking order theory. Our results show that earnings management has a negative impact on firm value in China, which supports the efficient earnings management view. We find that managers in Chinese firms are less likely to use excess cash for manipulating earnings. We provide empirical evidence that firms with excess cash seem to use it more for precautionary purpose than earnings management and the excess corporate liquidity of Chinese firms is used for value-enhancing activities. The test of robustness using the Instrumental Variable (IV) model confirms the results of the study. Our study merges two areas of corporate finance by incorporating agency problems concerning earnings management and cash holdings.
Patient Specific Cardiovascular Disease Modelling Based on the Computational Fluid Dynamics Simulations: Segmentation and Hemodynamic Model of a Thoracic Artery
Authors: AYDİN Levent , KUCUK Serdar , CAKİR Ozgur
Published: December 2019

Nowadays cardiovascular diseases (CVDs), mostly
coronary artery diseases become a leading cause of death. Flow dynamics of a
vessel is important to diagnose a CVD in advance. However, hemodynamic
parameters may not be measured directly. Hence, computational methods are
increasingly being used in the fields of neurosurgery and cardiovascular
surgery to obtain realistic physiological simulations. In this study, a patient
specific thoracic artery model is first segmented based on the MRI images and
then a thoracic aneurysm disease model is simulated to assess blood flow
changes under the predefined conditions.
FORMAS TRADICIONAIS E INOVADORAS DE TRATAMENTO NO PORTUGUÊS BRASILEIRO
Authors: Cantanhede Caio Sousa , Passerini Thiago Zilio
Published: December 2019

Apresentar-se-ão aqui algumas considerações sobre as formas de tratamento mais comuns e analisar-se-ão outros usos emergentes na língua portuguesa do Brasil, no que diz respeito a função vocativa que desempenham. A conceituação geral sobre as formas de tratamento será abordada, passando por um breve percurso histórico, em que se mensurará o advento, os usos e desusos de algumas formas, em Portugal e no Brasil. Serão analisados alguns trechos em que se destacam as principais formas de tratamento no Português brasileiro. Também, outras formas de tratamento serão levantadas, relacionadas diretamente à função vocativa, conforme assinala Azeredo (2013), utilizando trechos de registro oral, em que se evidenciam tais ocorrências, cujo contexto de uso é informal.
REPRESENTAÇÃO DISCURSIVA, IDENTIDADE E ALTERIDADE: ENTREVISTA EM ANÁLISE
Authors: Bezerra Jaqueline De Jesus , Queiroz Maria Eliete de
Published: December 2019

Este artigo focaliza a representação discursiva de si, categoria de análise do nível do texto, da Análise Textual dos Discursos (ATD) com base em Adam (2011), dialogando com os construtos da identidade e da alteridade, por meio, sobretudo, de Bakhtin (1997). O objeto de investigação é a entrevista de Marielle Franco[1] concedida ao site Brasil de Fato. Objetivamos analisar as construções identitárias através de representações discursivas de si, por meio da referenciação, de seus modificadores e da predicação, relacionadas à alteridade. A pesquisa é documental e qualitativa. Percebemos representações identitárias de Marielle Franco como mulher negra, resistente, lutadora, engajada.[1] Marielle Franco, assassinada em 14/03/2018, era Vereadora da Câmara do Rio de Janeiro pelo PSOL, presidiu a   Comissão da Mulher da Câmara, era socióloga e mestra em Administração Pública. Militou pelos direitos humanos, das mulheres e dos negros e atuou em organizações como o Centro de Ações Solidárias da Maré.
IDENTIFIKASI SENYAWA ANTIMIKROBA ALAMI PANGAN PADA EKSTRAK KULIT BUAH NAGA MERAH DENGAN MENGGUNAKAN GC-MS [Identification of Food Natural Antimicrobe Compound from Red Dragon Fruit Peel Extract by GC-MS]
Authors: Sartika Dewi , Sutikno Sutikno , Yuliana Neti , M Syarifah R
Published: December 2019

The red dragon fruit is a popular fruit in Indonesia. The leather of red dragon fruit was not used optimally. The other case, the peel of red dragon fruit have a natural antimicrobe potency. This research have aim to eksplore the leather of red dragon fruit as an antimicrobe with used GC-MS. The result of research showed that content of the peel of red dragon fruit was dominated by ascorbic acid, oleic acid, decanoat, phenol and ester compound, that had an antimcrobe potency. The aplication of the peel of red dragon fruit on Tongkol fish that was contaminated with E coli, showed that, there is a decrease of E coli as much as 1.47 x 109 koloni/g, significantly. The conclusion of research was the peel of red dragon fruit have a natural antimicrobe potency.
ANALISIS POTENSI LONGSOR LERENG BUKIT TUI KELURAHAN TANAH HITAM KOTA PADANG PANJANG SUMATERA BARAT MENGGUNAKAN APLIKASI SLIDE V6.0
Authors: Anaperta Yoszi Mingsi , Putra Septian Andika
Published: December 2019

Tui Hill is a limestone hill lined south of Padang Panjang. It is located between Rao-Rao Village and Tanah Hitam. Based on the results of investigations of researchers on the slopes of Bukit Tui limestone in the coordinates S0 ° 28'21.3 "E100 ° 24'00.4ʺ which are in the Tanah Hitam Village, there are many weak fields such as burly, steep slope geometry, influence on earthquake vibrations, and rainfall the high can lead to landslides on slopes, potential for landslides on the slopes of research can endanger road users and community settlements on slope locations. This study aims to analyze the potential of landslides based on the physical and mechanical properties of intact rocks, using the boundary equilibrium method. Then make reinforcement recommendations so that slope conditions are safe / stable. Based on the results of analysis and calculations in saturated conditions with the influence of earthquake factors 0,7 - 0,9g the values ​​of FK 1,461, 1,295, and 1,144 were obtained. From the results of the analysis, the slope is unsafe / unstable. In the original condition with 0.9g earthquake factor, FK 1.364 is obtained. Based on the results of analysis and calculations, the slope reinforcement recommendation used is the wire mesh installation method (wiremesh) in slope face.
EFEKTIFITAS MEKANISME TATA KELOLA TEKNOLOGI INFORMASI TERHADAP INOVASI TI DAN KINERJA TI
Authors: Fattah Anwar , Setyadi Resad
Published: December 2019

Information technology supports the achievement of business objectives in the organization. Higher education institutions is a business organization engaged in the field of education, research and devotion to the society in the Know Tridharma College.  Effective IT governance ensures the alignment between IT and the business objectives. The study seeks to examin empirically IT governance mechanisms affecting the overall effectiveness of IT governance. In addition, this study examines effective IT governance relationships and IT performance in higher education organizations. The sampling techniques in this study are multi-stage purposeful random sampling. In order, the researchers will incorporate the surveys online. Analyzed by Quantitative Data and method of a Partial Least Squares (PLS-SEM) equation using Smart PLS 3.0. The results obtained from this research show significant positive relationships between effectiveness IT governance and the following mechanisms: IT steering Committee, senior management involvement in IT, and organizational communication systems and relationships between the effectiveness of ITG with IT innovation and IT performance. And insignificant negative relationship between organizational Performance management system and effectiness IT Governance also IT Innovation and IT Performance.
Historisitas dan Tujuan Aturan Umur Minimal Perkawinan dalam Perundang-Undangan Keluarga Islam di Indonesia
Authors: Azizah Ulfi , Wahid Nur
Published: December 2019

This paper examines the minimum age requirement for marriage in Indonesian family law legislation in Indonesia historically. Determination of the minimum age for marriage in various countries is the result of ijtihad by considering the principle of physical and psychological maturity. In Indonesian marriage legislation sating that marriage is only permitted if the man reaches the age of 19 (nineteen) years and the woman has reached 16 (sixteen) years. Early marriage has several risks such as potential premature births, birth defects, maternal depression rates, maternal mortality rates, risk of contracting sexually transmitted diseases. Therefore, the authors strongly agree that the minimum age of marriage in Indonesia changed to 19 years
Kedudukan Hukum People Power dan Relevansinya dengan Hak Kebebasan Berpendapat di Indonesia
Authors: Susanto Muhamad Iqbal
Published: December 2019

This article is here to examine the legal position of People Power which is associated with the constitutional movement considering that interpretations relating to People Power in Indonesia are still very diverse. The writing method used is the deductive method. This article concludes that People Power is synonymous with the spread of propaganda both through social media, demonstrations, and the greater emphasis on resources mobilized. Then People Power if it is related to constitutional rights based on Article 28 of the 1945 Constitution, concerning association and assembly, expressing thoughts verbally and in writing. Of course as long as it is still in the corridor mandated by the 1945 Constitution, the People Power in question is considered constitutional activity. But on the contrary if the people power is outside the corridor of the 1945 Constitution, where the intended People Power is intended to overthrow by force a legitimate government, then it will automatically be considered as an unconstitutional movement.
Pembubaran Organisasi Kemasyarakatan dalam Perspektif Hak Kebebasan Berserikat Berdasarkan Konstitusi Negara Republik Indonesia
Authors: Firosa M. Asfa
Published: December 2019

This article is intended to address the problem of the dissolution of social organizations as stated in social organizations law viewed from the principles of state law, democracy and human rights. The method used is normative juridical. The approach used is the statutory approach and conceptual approach. This article concludes that the mechanism for dissolution of civil society organizations has become more concise by not passing through the courts because of the inclusion of the contrarius actus principle. This is not in accordance with the principles of state law, democracy and human rights. Social Organization as an important instrument in democracy and a form of freedom of association, the dissolution has to be decided through a due process mechanism of law by an independent court. This legal process becomes very important because the dissolution carried out by an executive institution unilaterally will lead to arbitrariness.
Pathomorphological changes in vital organs of the Volga fishes
Authors: Fedorova Nadezhda Nickolaevna , Grushko Maria Pavlovna , Kanieva Nuria Abdrakhimovna
Published: December 2019

The paper presents monitoring of pathological changes in the microstructure of cells and tissues of fish organs living in the lower reaches of the Volga River due to the need to identify the consequences of the environmental impact of oil and gas production enterprises located in the Astrakhan region. There have been revealed the research results of studying the state of some Volga fish species in modern conditions of their habitat. A histological analysis of the organs and tissues of pike, asp and perch was carried out. In the course of studies it was found out that all fish species studied, especially pike, had encapsulated helminthic cysts in the muscles, gills and intestines. In the fish kidneys there have been found signs of nonspecific inflammatory reactions (microcirculatory disorders, alteration and proliferation of tissues) with a predominance of dystrophic and necrotic phenomena. Fatty degeneration of varying degrees of development was detected in the liver of fish; in addition, there were observed growing connective tissues and microcirculation disorders. In all organs of the fish studied, especially in the liver, hemosiderosis was found. Epithelial proliferation and goblet cell hypertrophy were detected in the gills and intestines.
Influence of water temperature on metabolic energy structure in fish
Authors: Egorova Vera Ivanovna , Sveshnikova Elena Vasilyevna , Naumova Valentina Vasilyevna , Kiryanov Dmitry Anatolyevich , Smirnova Anna Nikolaevna
Published: December 2019

The paper gives the analysis of the influence of water temperature on the structure of metabolic energy in carp and silver carp of different age groups. The thermophilic species

of carp and spotted silver carp cultivated in the polyculture with natural nutritive base served as the material for a research conducted in a hatchery “Individual Enterprise of Alekseeva M. V.” in Kuzovatovsky district of the Ulyanovsk region. Analysis of fish metabolic energy was made using the mean of live weight of yearlings and two-year-old species of carp and silver carp. As a result, there have been obtained the values of the metabolic energy in fingerlings and two-year-old species of carp and silver carp at different ranges of water temperature. Metabolism in carp and silver carp species being representatives of thermophilic fish is most effective at temperatures within +18-+30°С. The study showed that a decrease in water temperature by 5°C (from 20 to 15°C) causes a decrease in food activity, the daily feed intake of yearlings and two-year-old species of carp and silver carp decreased by 35-40%. Expense for the basal metabolism and growth did not change. Metabolic energy was used by 10.8-13,3.0 kJ less. Also, yearlings and two-year-old species of carp and silver carp spent less energy on motion activity than in the warmer water. Thus, under a decrease in the water temperature in the pond the costs of maintaining thermal homeostasis in fish increased, while the costs of basal metabolism, on the contrary, decreased. Situation is quite different when the water is warmed up.