bluuebunny/crossref_metadata_2025 huggingface dataset:
Figure 2 from Characterization of the Breast Cancer Liver Metastasis Microenvironment via Machine Learning Analysis of the Primary Tumor Microenvironment
Authors: Goodin Dylan A. , Chau Eric , Zheng Junjun , O’Connell Cailin , Tiwari Anjana , Xu Yitian , Niravath Polly , Chen Shu-Hsia , Godin Biana , Frieboes Hermann B.
Published: October 2024

Representative H&E-stained slices of normal and tumor tissue, and corresponding IMC images from (A) breast and (B) liver tissue. H&E, hematoxylin and eosin.
Data from Characterization of the Breast Cancer Liver Metastasis Microenvironment via Machine Learning Analysis of the Primary Tumor Microenvironment
Authors: Goodin Dylan A. , Chau Eric , Zheng Junjun , O’Connell Cailin , Tiwari Anjana , Xu Yitian , Niravath Polly , Chen Shu-Hsia , Godin Biana , Frieboes Hermann B.
Published: October 2024

Abstract
Breast cancer liver metastases (BCLM) are hypovascular lesions that resist intravenously administered therapies and have grim prognosis. Immunotherapeutic strategies targeting BCLM critically depend on the tumor microenvironment (TME), including tumor-associated macrophages. However, a priori characterization of the BCLM TME to optimize therapy is challenging because BCLM tissue is rarely collected. In contrast to primary breast tumors for which tissue is usually obtained and histologic analysis performed, biopsies or resections of BCLM are generally discouraged due to potential complications. This study tested the novel hypothesis that BCLM TME characteristics could be inferred from the primary tumor tissue. Matched primary and metastatic human breast cancer samples were analyzed by imaging mass cytometry, identifying 20 shared marker clusters denoting macrophages (CD68, CD163, and CD206), monocytes (CD14), immune response (CD56, CD4, and CD8a), programmed cell death protein 1, PD-L1, tumor tissue (Ki-67 and phosphorylated ERK), cell adhesion (E-cadherin), hypoxia (hypoxia-inducible factor-1α), vascularity (CD31), and extracellular matrix (alpha smooth muscle actin, collagen, and matrix metalloproteinase 9). A machine learning workflow was implemented and trained on primary tumor clusters to classify each metastatic cluster density as being either above or below median values. The proposed approach achieved robust classification of BCLM marker data from matched primary tumor samples (AUROC ≥ 0.75, 95% confidence interval ≥ 0.7, on the validation subsets). Top clusters for prediction included CD68+, E-cad+, CD8a+PD1+, CD206+, and CD163+MMP9+. We conclude that the proposed workflow using primary breast tumor marker data offers the potential to predict BCLM TME characteristics, with the longer term goal to inform personalized immunotherapeutic strategies targeting BCLM.
Significance:
BCLM tissue characterization to optimize immunotherapy is difficult because biopsies or resections are rarely performed. This study shows that a machine learning approach offers the potential to infer BCLM characteristics from the primary tumor tissue.
Whys and Wherefores of Coronary Arterial Positive Remodeling
Authors: Onnis Carlotta , Virmani Renu , Madra Anna , Nardi Valentina , Salgado Rodrigo , Montisci Roberta , Cau Riccardo , Boi Alberto , Lerman Amir , De Cecco Carlo N. , Libby Peter , Saba Luca
Published: October 2024

Positive remodeling (PR) is an atherosclerotic plaque feature defined as an increase in arterial caliber at the level of an atheroma, in response to increasing plaque burden. The mechanisms that lead to its formation are incompletely understood, but its role in coronary atherosclerosis has major clinical implications. Indeed, plaques with PR have elevated risk of provoking acute cardiac events. Hence, PR figures among the high-risk plaque features that cardiac imaging studies should report. This review aims to provide an overview of the current literature on coronary PR. It outlines the pathophysiology of PR, the different techniques used to assess its presence, and the imaging findings associated to PR, on both noninvasive and invasive studies. This review also summarizes clinical observations, trials, and studies, focused on the impact of PR on clinical outcome.
Who’s on First?
Authors: Stephenson Christopher A.
Published: October 2024

The terms first, second, and third article theology are relatively new, and theologians use them equivocally. Veli-Matti Kärkkäinen’s first article theology focuses on the doctrines of God, revelation, and creation in and of themselves, that is, on theological topics broadly associated with the first article of the Creed. Another way to approach first article theology is to make a theology of the Father the perspective from which to view other systematic loci. Pentecostal theologians might benefit from such a theological inquiry, if for no other reason than as an exercise in the discipline associated with rigorous systematic thinking and as training in the kind of speculative theology that they have traditionally avoided. A methodology marked by a theology of the Father in trinitarian perspective and brought to bear upon other systematic loci might be compatible with a methodology marked by the liturgical theology axiom lex orandi, lex credendi.
Unequal Treaty in Practice: A Story about Article 23 of the Treaty of Tientsin
Authors: Chan Shiu Chung
Published: October 2024

Despite the wealth of research on cross-border activities between China proper and Hong Kong, little has been discussed about the ‘civil fugitives’ who fled from one side to the other during Hong Kong’s early colonial period. Chinese debtors who absconded to China created jurisdictional problems for Hong Kong. The addition of Article 23 in the Treaty of Tientsin was an attempt to solve this issue, and this article explores what the discussions on Article 23, particularly those from 1905 to 1907 among British colonial officials and diplomatic agents, reveal about the characteristics of colonial jurisdiction under international law. In this case, colonial jurisdiction was limited solely to the territory of Hong Kong. Proposals to amend Article 23 attempted to remove the territorial barrier and establish personal jurisdiction for the colonial government in Hong Kong, similar to extraterritorial rights in Qing China.
In vitro validation of colon delivery of vitamin B2 through a food grade multi-unit particle system
Authors: Steinert R.E. , Sybesma W. , Duss R. , Rehman A. , Watson M. , van den Ende T.C. , Funda E.
Published: October 2024

Colon target delivery of active ingredients is frequently applied in pharmaceutical products. However, in functional food and beverage applications, dietary supplements, and medical nutrition, formats targeting colonic delivery to improve human health are rare. Nevertheless, there is emerging evidence for beneficial effects of colonic delivered nutrients on gut microbiota and host health which increases the demand for sustainable food grade materials that are regulatory approved for application. In this paper, we describe a double layer coated multi-unit particle system (MUPS) with a diameter of approximately 730 microns consisting of food grade materials: shellac as outer layer, alginate as inner layer, cellulose as a core and riboflavin as active ingredient. The suitability of the MUPS for colonic delivery was tested in three well-established in vitro digestion and fermentation models: the USP Apparatus 3 and the TNO Intestinal Models 1 and 2 (TIM-1 and TIM-2). All systems confirmed the integrity of the MUPS under simulated upper gastrointestinal tract conditions with approximately 90% of the active ingredient being released under simulated ileal-colonic conditions. The TIM-2 model also showed the effects of riboflavin loaded MUPS on the microbiome composition with an increase in the production of short-chain fatty acids, acetate and butyrate. The results of these experiments provide a reliable basis for validation of this vitamin-loaded food grade MUPS in future human clinical trials. In addition, following the recent announcement of the European Commission to restrict intentionally added microplastics to products, the materials used in the described formulation offer an environmentally friendly alternative to often applied methyl acrylate based coatings.
Oral supplementation of heat-killed Enterococcus faecalis strain EC-12 relieves gastrointestinal discomfort and alters the gut microecology in academically stressed students
Authors: Li J. , Terajima T. , Liu H. , Miyata S. , Kambe J. , Makioka-Itaya Y. , Inoue R. , Yamamoto Y. , Nagaoka K.
Published: October 2024

Stress significantly affects gastrointestinal and mental health, and the gut microbiota plays a pivotal role in this process. Enterococcus faecalis strain EC-12 (EC-12) is a lactic acid bacterium that has several health benefits. To investigate the impact of oral supplementation with heat-killed EC-12 on the discomfort caused by stress, a randomised, double-blind, placebo-controlled trial was conducted with students under academic stress taking EC-12 (n = 14) or a placebo (n = 13) daily for one week. Improvement in the students’ symptoms was assessed using the visual analogue scale. Faecal microbiota was characterised by next-generation sequencing of 16S rRNA genes, and faecal metabolites and short-chain fatty acids were analysed using a GC-MS metabolomics approach. Significant improvements in abdominal pain and rumbling of the stomach were found in the EC-12 group compared to the placebo group, but no changes were observed in mental symptoms or salivary cortisol levels. The relative abundance of E. faecalis significantly increased in the EC-12 group after the trial; however, the composition and diversity of the gut microbiota did not change significantly. Functional analysis of the gut microbiota suggested that EC-12 intake alters specific metabolic pathways. Although the levels of faecal short-chain fatty acids did not change between the groups before and after the trial, EC-12 intake altered the composition of faecal metabolites, with a significant increase in tryptamine levels. The ratio of students with improved symptoms to those with increased tryptamine levels was calculated based on the number of students with elevated faecal tryptamine levels who showed symptomatic improvements. The ratio of improved rumbling stomach was higher than that of other types of digestive discomfort. These results suggest that oral supplementation with EC-12 has a potentially beneficial effect on stress-induced gastrointestinal discomfort, which may occur through alterations in gut microbiota composition and metabolism.

This study was registered at the University Hospital Medical Information Network Center (UMIN) under the UMIN ID: UMIN000048184
Art of Failure: Soni Kum’s Morning Dew Project and Diasporic Aesthetics
Authors: Kim Soyi
Published: October 2024

To date, one of the first video artworks by and about Zainichi (ethnic Koreans living in Japan), Zainichi artist Soni Kum’s three-channel video work Morning Dew (2020) is based on her interviews with sixteen Zainichi Koreans who went to North Korea during the repatriation project (1959–1984) and came back to Japan, and their descendants. I argue that Morning Dew, deliberately fails to give a coherent Zainichi representation, and in doing so, locates Zainichi experience in a context of the global diaspora, especially through the incongruent video montages on three screens, having animals lead the narrative, and filming the void. Queer imagination of failure helps explain the ways in which Kum’s aesthetic choices and her lived experience intersect. Responsive to the bifurcated gender discourse that threatens the legibility of queer lives, queer failure helps to unveil the structural polarization in identity-based knowledge formation and explicate Kum’s art of failing as a means to convey a portrayal more faithful to the diasporic life of Zainichi Koreans.
Confronting Power: Bani Abidi and Performances of Masculinity
Authors: Greenwalt Karen
Published: October 2024

Contemporary Pakistani artist Bani Abidi explores the overlapping and multifaceted relationship between performance, nationalism, and machinations of power. This article focuses on a subset of her work that considers how masculinity relates to these ideas. Specifically, in the works discussed in this article, she interrogates the ways masculinity is produced and maintained, ultimately revealing the hollowness of such performances. Abidi’s own diasporic perspective centres South Asian culture and identities throughout her practice. She draws our attention to universal conditions that govern the world, but does so within a specifically South Asian context. Her work points to the fictive and limiting nature of gender roles, revealing how these performances of political masculinity are legacies of the colonial encounter. By examining how the performance of masculinity operates as a mechanism of power within Abidi’s work, this article uncovers how her work addresses displays of nationalism in Pakistan and India, particularly as it relates to the region’s post colonial history.
How to Place Displacement: Yuna Kim’s Stacking, Collapsing, and Stacking
Authors: Kim Amy Yeminne
Published: October 2024

Yuna Kim’s video work Stacking, Collapsing, and Stacking was part of the group exhibition Common Occurrences: Four Korean Artists living in the U.S., which also featured Sangmi Yoo, Ray Im, and Mizin Shin. Held from 15 September through 31 October 2022, the exhibition aimed to introduce contemporary South Korean viewpoints to the majority first-generation students and the largely Hispanic audiences of the Permian Basin of Texas. Comprised of twenty-eight delicately animated vignettes, Kim’s usage of basic rotoscoping techniques and sound design examines mounting tension in our everyday visual world.
Thinking with and beyond Castoriadis: Conversation with Peter Wagner
Authors: Adams Suzi , Arnason Johann P , Blokker Paul , Smith Jeremy CA , Wagner Peter
Published: October 2024

This conversation between Peter Wagner and members of the Social Imaginaries Collective addresses two aspects of Wagner’s project. First, it enquires into the significance of Cornelius Castoriadis’s project for Wagner’s social theory and historical sociology. Second, the conversation turns to Wagner’s reflections on the ongoing significance of Castoriadis’s thought to the pressing political questions of our times, including the ecological crisis and post-communist societies.
Corrections to Some Recently Published Papers on Heteroptera (Hemiptera)
Authors: KMENT PETR , SALINI S. , CARAPEZZA ATTILIO , RIDER DAVID A.
Published: October 2024

We provide corrections to 17 recent papers (published since 2013). The following new combination is proposed: Dabessus indicus Kushwaha and Jahan, 2023 = Neojurtina indica (Kushwaha and Jahan, 2023), new combination. The following corrections are provided: Miridae: Tytthus chinensis sensu Al-Anbaki et al. (2023) = Maurodactylus nigrigenis (Reuter, 1890) (from Iraq); Pentatomidae: Antestiopsis thunbergii sensu Zhao et al. (2021) = Anaxilaus musgravei Gross, 1976 (from Australia), Andrallus spinidens sensu Kaur (2024) = Erthesina sp., Carpocoris pallidus sensu Keshari and Mahto (2017) = Antheminia sp., Dalpada neoclavata sensu Kaur (2024) = Dalpada bulbifera Walker, 1867, Halyabbas unicolor sensu Singh et al. (2013) = Palomena sp., Nezara antennata sensu Kaur (2024) = Nezara viridula (Linnaeus, 1758), Paranevisanus subgenericus sensu Kaur (2024) = Paranevisanus annandalei (Distant, 1908), Picromerus obtusus sensu Kaur (2024) = Eocanthecona furcellata (Wolff, 1811), Priassus spiniger sensu Kaur et al. (2019) = Priassus exemptus (Walker, 1868), Priassus exemptus sensu Kaur et al. (2019) = Udonga montana (Distant, 1900), Sciocoris lateralis sensu Kaur et al. (2016) = Menida formosa (Westwood, 1837), and Tolumnia maxima sensu Kaur et al. (2017) = T. latipes (Dallas, 1851) from India. The records of Reduvius personatus (Linnaeus, 1758) (Reduviidae), Nabis roseipennis Reuter, 1872 (Nabidae), Anthocoris nemoralis (Fabricius, 1794) (Anthocoridae), Peritropis saldaeformis Uhler, 1891 and Lygus lineolaris (Palisot de Beauvois, 1818) (both Miridae), Oncopeltus fasciatus (Dallas, 1852) (Lygaeidae), Alydus calcaratus (Linnaeus, 1758) (Alydidae), Leptoglossus phyllopus (Linnaeus, 1767) (Coreidae), Cydnus aterrimus (Forster, 1771) (Cydnidae), Chinavia hilaris (Say, 1832) and Halyomorpha halys (Stål, 1855) (Pentatomidae), Corimelaena pulicaria (Germar, 1839) (Thyreocoridae), and Calliphara excellens (Burmeister, 1834) (Scutelleridae) from Nigeria, and records of Nepa cinerea Linneaus, 1758 (Nepidae), Velia caprai Tamanini, 1947 (Veliidae), Coreus marginatus (Linnaeus, 1758) (Coreidae), Chlorochroa ligata (Say, 1832), Graphosoma lineatum (Linnaeus, 1758), Halyomorpha halys and Palomena prasina (Linnaeus, 1761) (Pentatomidae) from India are demonstrated to be apparent errors. In addition, we propose, Antheminia sariabensis (Ahmad and Zaidi, 1991), new combination (for Codophila sariabensis Ahmad and Zaidi, 1991), fix its original correct spelling, and provide three new country records: Priassus exemptus from Laos, Priassus spiniger from Malaysia, and Tolumnia maxima from Brunei.
Three New Species of the Genus Mendozaphylus Carvalho and Carpintero (Heteroptera: Miridae: Phylinae), with Discussion of Its Tribal Placement and a New Generic Synonym
Authors: CARPINTERO DIEGO L. , CHÉROT FRÉDÉRIC , HENRY THOMAS J.
Published: October 2024

The genus Mendozaphylus Carvalho and Carpintero, 1991, endemic to Argentina, is reviewed. Mendozaphylus payuniense new species from Mendoza, M. similaris new species from Salta, and M. volckmannii new species from Neuquén are described as new. The nominal genus Ampimpacoris Weirauch and Schuh, 2010 is synonymized with Mendozaphylus, resulting in the following new combination: Mendozaphilus flourensii (Weirauch and Schuh, 2010), new combination. Mendozaphylus flourensii from Tucuman and M. mendocinus Carvalho and Carpintero, 1991, the type species from Mendoza, are briefly redescribed, and the tribal placement of Mendozaphylus is discussed.
Trichoderma azadirachtae sp. nov. from rhizosphere soil of Azadirachta indica from Guangdong Province, China
Authors: HUANG QIU-RONG , SENANAYAKE INDUNIL C. , LIU JIA-WEI , CHEN WEN-JING , DONG ZHANG-YONG , LUO MEI
Published: October 2024

Trichoderma species are distributed worldwide and they play an important role in plant protection, growth promotion and also as biocontrol agents of plant diseases. In this study, a new species of Trichoderma was isolated from Azadirachta indica rhizosphere soils in Zhaoqing City, Guangdong Province, China. Based on the morphology and combined multigene phylogeny of nuclear internal transcribed spacer of rDNA region (ITS), translation elongation factor 1 alpha (tef1-α) and RNA polymerase second largest subunit (rpb2), a new Trichoderma species belongs to the Harzianum-clade was identified, namely Trichoderma azadirachtae sp. nov. Distinctions between the new species and its close relatives are discussed in detail.
Two new species of Pluteus (Pluteaceae) from India based on morphology and ITS-based phylogeny
Authors: KEERTHI V. , JUSTO ALFREDO , PRADEEP C.K.
Published: October 2024

Two new Pluteus species, P. fuscipruinatus and P. chimminiensis belonging to sect. Celluloderma, are described based on specimens collected from Kerala state, India. Maximum Likelihood phylogenetic analysis using nrITS revealed that P. fuscipruinatus belongs to the /ephebeus clade, while P. chimminiensis belongs to the cinereofuscus clade. Detailed descriptions supplemented with field images, microscopic features, phylogenetic analysis, and comparative assessments with allied taxa are provided. A key to the species of Pluteus sect. Celluloderma known to occur in India is also provided.
A new record of Begonia aptera in Southern Mindanao: the second species of Begonia sect. Platycentrum recorded from the Philippines
Authors: ESPEJA BRYLL L. , BUCAY MARK ANGELO C. , TANDANG DANILO N. , RUBITE ROSARIO R. , CHEN HONG-WUN , CHUNG KUO-FANG , BAUTISTA MAJELLA G.
Published: October 2024

Begonia aptera was recently found during expeditions in the Matutum and Melibengoy mountains in South Cotabato province, southern Mindanao island, Philippines. The identification of the species was affirmed by the morphological similarities of the samples to specimens from the neighbouring island of Sulawesi in Indonesia. Begonia aptera is a member of the Begonia longifolia complex by having berry-like dull green, rhomboidal to spherical fruits with three locules, axillary, dichasial inflorescense, 4-tepaled male and 6-tepaled female flowers. Begonia aptera is distinct by having broadly elliptic leaves with bi-tooothed, serrate margins. This is just the second member of Begonia sect. Platycentrum in the Philippines, the only member of this section being B. halconensis endemic to Mindoro Island, with all other Philippine Begonia falling into sections Petermannia and Baryandra. It is proposed that the species be declared as vulnerable in the Philippines due to the fragmented population observed and potential threats to the observed populations.
The Okuru skink (Oligosoma carinacauda sp. nov) of South Westland, New Zealand—simply elusive or extinct?
Authors: BELL TRENT , PATTERSON GEOFF B.
Published: October 2024

A small brown, longitudinally striped skink from Okuru, South Westland, New Zealand is described as Oligosoma carinacauda sp. nov. It is distinguished from all congeners by the combination of three supraocular scales and a keeled tail. The species is known only from a single specimen, collected from sphagnum moss within supralittoral dune habitat at Mussel Point, Okuru in 2000. Follow-up targeted surveys undertaken since by expert herpetologists have failed to relocate the species to date. As it is known that many New Zealand lizard species face a perilously uncertain future due to anthropogenic-induced pressures such as habitat loss, predatory pests, and climate change, there are serious concerns for the survival of this species.
Contract Farming in Low and Lower-Middle-Income Countries: Using Meta-Analysis and Factor Analysis
Authors: Abreham Getahun , Ayalew Zemen , Chanie Essa , Muchie Mammo , Sete Yordanos
Published: October 2024

Purpose: Smallholder farmers' agriculture in developing countries particularly in low and lower-middle-income countries is known for poor production and productivity levels which has been related to the inadequate use of improved agricultural inputs and marketing systems, and in this case, contract farming. Therefore, this study aimed to investigate the various factors which affect contract farming among smallholder farmers in developing countries. However, trying to investigate those contract farming determinants by a single analytical method leads it to have limited findings, narrowed generalizability and difficulty in investigating major determinants that determine contract farming success. Therefore, a joint approach using factor analysis and meta-analysis can give a more comprehensive understanding of contract farming factors. Methodology: The data was gathered through a Systematic Literature Review, finding a total of 3007 studies from SCOPUS, PubMed, PubAg, and EMBASE. The PRISMA method was applied to, and finally, 35 peer-reviewed articles in English between January 1990 to September 2023 were selected. Findings: The meta-analysis showed interesting insights into factors influencing contract farming participation. Education and household size exhibited a negative association, suggesting that farmers with higher education levels and larger families may be less likely to participate in contract farming arrangements. This could be due to a preference for independent decision-making or the need for family labor in alternative income-generating activities. On the other hand, farmers with larger landholdings are more inclined to participate. To encourage broader participation, policymakers, and program designers could consider targeted outreach and support services for these specific demographics. Originality and value: Our new approach, joining meta-analysis and factor analysis, sheds innovative light on contract farming determinants. While the expected determinants like farm and household size, along with education, remained significant, our analysis showed unexpected nuances. Age of the household head emerged as potentially favoring younger, less experienced farmers. Moreover, access to extension services played an important role, while large household size might have a more complex influence depending on age composition. This comprehensive approach offers valuable insights for targeted outreach programs and collaboration with extension services to optimize contract farming adoption and success in developing countries.
Reference Values for Some Serum Biochemical Parameters of Adult Male of Libyan and Sudanese Camels in North Africa, Libya
Authors: Abudabos Adel , Alhemmali Esmail , Shtewi Hanan , Swaib Nessrin , Shlak Fatma
Published: October 2024

The normal concentrations of some blood constituents were determined in adult one-humped camels from Libya and Sudan. The current study employed the Mindray BC-5000 analyzer to conduct biochemical measurements on thirty adult dromedary camels. Results obtained were compared and interpreted in light of findings reported by other researchers about camelids. The study investigated the normal concentrations of blood constituents in adult one-humped camels from Libya and Sudan. The results indicated that the mean values of total protein were 8.59 ± 0.64 g/dL and 8.74 ± 0.37 g/dL in the Libyan and Sudanese camels, respectively. For albumin, the mean concentrations were 3.47±1.03 g/dL and 3.92±0.53 g/dL, while for globulin, they were 5.03±0.41 g/dL and 4.83± 0.44 g/dL in experimental animals respectively. The mean Na concentrations were 153.44 ± 3.04 mmol/l in Libyan camels and 164.39 ± 4.29 mmol/l in Sudanese camels. Ca levels were found to be 11.89 ± 0.74 mmol/l and 9.90 ± 1.37 mmol/l in Libyan and Sudanese camels, respectively. The values of K concentrations showed 5.880 ± 0.102 mmol/l and 6.860 ± 0.249 mmol/l in Libyan and Sudanese camels respectively. While ESR was measured at 0.40 ± 0.13 mmol/c in the study. Conclusion, the study provides a preliminary report on hematological and serum biochemical parameters of camel in North Africa (Libya). Furthermore, future studies can explore blood standards and biochemical measurements across various age groups of Camelus dromedaries to enhance the applicability and interpretation of biochemical data in camel research.
A Comparative Study of Columellar Strut and Septal Extension Grafts for Tip Support in Rhinoplasty
Authors: Aldosari Badi , Aldhwaihy Lulu , Bogari Ahmad
Published: October 2024

Background: Rhinoplasty is one of the most common aesthetic surgical procedures. Columellar strut and septal extension grafts are commonly used for tip support, but their long-term effectiveness and stability remain debated. This study aims to compare the long-term postoperative stability of these two techniques. Methods: A retrospective cohort study of patients underwent primary rhinoplasty using either columellar strut or septal extension grafts between March 2021 and March 2022 was conducted. Nasal tip projection and rotation stability were analyzed through photographic evaluations conducted preoperatively, as well as at 6 and 18 months postoperatively. Additionally, participant’s satisfaction and the incidence of postoperative complications were assessed. Results: Both grafting techniques exhibited an initial increase in tip projection, followed by a slight regression at later stages. However, this change was not statistically significant for either group. A distinct difference emerged in tip rotation, as measured by the nasolabial angle. The columellar strut group experienced a notable increase in tip rotation initially, followed by a significant decrease, while the septal extension graft group exhibited minimal and statistically insignificant changes in tip rotation over the same period. Conclusion: Nasal tip rotation was more stable in cases with septal extension grafts compared to those with columellar strut grafts.
Estimating T2DM Risks Among Teachers in a Developing Country Using a Nomogram Comprising the Healthy Lifestyle Index and Other Predictors
Authors: Ng Yit Han , Moy Foong Ming , Hairi Noran Naqiah , Bulgiba Awang
Published: October 2024

A nomogram provides a novel solution for assessing the risks of type 2 diabetes among teachers. This is particularly effective when the nomogram incorporates the Healthy Lifestyle Index (HLI) and relevant predictors. In this study, we followed up with a group of teachers from the CLUSTer cohort using RedCap and linked it with the Malaysian National Diabetes Registry. A Cox proportional hazard model was used to determine the predictors associated with T2DM risk in teachers during the follow-up period. We translated our findings into an online interactive nomogram. A total of 3477 teachers were included in the study, of whom 697 (20.0%) were ultimately diagnosed with T2DM. The Cox regression model revealed that HLI and 11 other predictors were significantly associated with diabetes risks among teachers. A nomogram that predicted the risks of T2DM at five, seven, and nine years was developed. Of the 12 predictors, age, fasting blood glucose (FBG), and HLI contributed the most to the total score. Combining the HLI with other predictors in a nomogram allows teachers to assess their T2DM risks and take action to prevent the development of T2DM.
Waist-to-Height Ratio as a Key Predictor for Diabetes and Hypertension in Lao PDR National Health Survey
Authors: Ratsavong Kethmany , Essink D. R. , Vonglokham Manithong , Kounnavong Sengchanh , Sayasone Somphou , Aekplakorn Wichai , Worawichawong Suchin , Wright E. P.
Published: October 2024

This study aimed to determine the potential predictive value of four noninvasive anthropometric indices in screening for the risk of diabetes and hypertension in the Lao population. The data used for this study were collected as part of the National Health Survey which used the World Health Organization’s stepwise approach, covered 17 provinces and Vientiane capital, and had a representative sample of 3240 participants above 18 years old. Among the anthropometry indices tested, waist-to-height ratio (WHtR) had the highest predictive power for the prevalence of diabetes (area under the curve [AUC] = 0.73) and hypertension (AUC = 0.70). It is suitable for use in urban or rural areas and for fieldwork. The WHtR can serve as a public health and clinical screening tool, as there are no differences between sexes, ages, and ethnicities when monitoring diabetes and hypertension risk in Lao PDR, using the optimal cutoff point of 0.5 for both diabetes and hypertension.
Autoethnography as Social Science or as Social Study?
Authors: Badley Graham Francis
Published: October 2024

In this research article, I examine the thoughts why autoethnography should be considered as social study rather than as social science. I suggest that autoethnographers are comfortable with the artistic and literary turn in qualitative inquiry since it helps them illuminate and illustrate their main concerns and purposes. I conclude by selecting seven main purposes of autoethnography including what some regard as its major concern—achieving Dewey’s democratic and utopian dream.
Efficacy of Treatments in Reducing Facial Erythema in Rosacea: A Systematic Review
Authors: Hua Nicholas J. , Chen Jennifer , Geng Ryan S. Q. , Sibbald Ronald Gary , Sibbald Cathryn
Published: October 2024

Rosacea is a chronic inflammatory skin condition that affects over 5% of individuals worldwide. Its clinical presentation is characterized by an array of features, including erythema, papules and pustules, phymatous changes, telangiectasia, and ocular manifestations. Specifically, the multifaceted manifestation of erythema varies widely in intensity and distribution. Factors contributing to pathogenesis include neurovascular dysregulation, increased levels of pro-inflammatory mediators, and aberrant vasodilation. Erythema management plays an important role in reducing the psychosocial burden associated with rosacea and improving overall quality of life. Cochrane CENTRAL, Medline, and Embase databases were searched from inception to September 2023 and included 33 clinical trials reporting on a total of 7411 rosacea patients (74.1% female) and 21 different topical or systemic treatments. The mean age was 48.8 years (range, 18-83 years), and the mean time to outcome assessment was 8.1 weeks (standard deviation, 4.1 weeks). Treatment efficacy was assessed by outcome measures including percent improvement from baseline on 4- and 5-point scales, clinician erythema assessment (CEA) success (improvement ≥1 point), and CEA and patient self-assessment success (improvement ≥1 point). Pooled effect sizes for each treatment were calculated as a weighted average based on the number of patients in each study. The most effective topical treatments for reducing erythema include sodium sulphacetamide and sulphur, praziquantel, metronidazole, and B244 spray ( Nitrosomonas eutropha). The most effective systemic treatment was paroxetine. Our findings highlight the varying efficacy of treatments in addressing the erythema in rosacea, recognizing the nuances of clinical presentations.
The efficacy and safety of tofacitinib in anti-melanoma differentiation-associated gene 5 antibody positive dermatomyositis associated interstitial lung disease: a systematic review and meta-analysis
Authors: Wang Yanhong , Zou Ruyi , Wei Jie , Tang Cheng , Wang Junjie , Lin Minjie
Published: October 2024

Background:

The presence of anti-melanoma differentiation-associated gene 5 (MDA5) antibodies in dermatomyositis (DM) is associated with an increased risk of developing rapidly progressive interstitial lung disease (RP-ILD) and a poor prognosis.

Objectives:

We aimed to explore whether tofacitinib could improve the prognosis of Anti-MDA5 antibody positive DM-interstitial lung disease (ILD).

Design:

Systematic review and meta-analysis.

Data Sources and Methods:

Studies were included if they compared mortality rate and infection events in patients with anti-MDA5 antibody positive DM-associated ILD who were treated with or without tofacitinib.

Results:

The systematic review and meta-analysis included a total of 148 patients from four cohort studies. Fifty-eight patients with anti-MDA5 antibody positive DM-ILD who received combined treatment-containing tofacitinib were enrolled in the experimental group. Additionally, 90 DM-ILD patients who did not receive tofacitinib-based therapy were included in the control group. The pooled risk ratio (RR) for all-cause mortality was 0.61 (95% CI, 0.41–0.91, p = 0.02) with I2 = 0 indicating no heterogeneity among the included studies. For virus infection risk, the pooled RR was 1.92 (95% CI, 0.90–4.10, p = 0.09), while bacterial and fungal infection-associated RRs were found to be 1.29 (95% CI, 0.65–2.55, p = 0.47) and 1.15 (95% CI, 0.46–2.89, p = 0.77), respectively. There was no statistically significant difference in infection risk between the two groups, and no heterogeneity was observed.

Conclusion:

Our findings suggest that tofacitinib may reduce the risk of all-cause mortality in patients with anti-MDA5 antibody-positive DM-ILD without an increased risk of additional infections.

Trial registration:

PROSPERO: CRD42023445427; https://www.crd.york.ac.uk/prospero/
Psychometric Properties of the Family Resilience Assessment Scale for Children With Disabilities in China
Authors: Boqiong-Tian  , Renhong-Shen  , Rujun-Huang  , Qiong-Xu Su
Published: October 2024

The study aimed to explore the factor structure and psychometric properties of the Chinese version of the Family Resilience Assessment Scale for Children with Disabilities (FRAS-CWD). Due to the complexity of family resilience and the particularity of disabilities, there is a lack of reliable and valid tools to evaluate family resilience for children with disabilities in China. Data were collected from 767 Chinese parents of children with disabilities. Item analysis (IA), exploratory factor analysis (EFA), and confirmatory factor analysis (CFA) were used to test the discrimination of items, determine the factor structure and model fit, also with a Cronbach’s alpha for reliability test. EFA analysis yielded a 34-item 7-factor structure of the FRAS-CWD, which demonstrated satisfactory model fit by CFA analysis. The FRAS-CWD also showed good internal consistency. The FRAS-CWD is reliable and valid for evaluating family resilience for children with disabilities in China, reflecting the Chinese socio-cultural characteristics. Relevant professionals and practitioners such as family therapists and social workers can use the FRAS-CWD to assess family strengths and facilitate intervention for families of children with disabilities experiencing adversity.
COVID-19 Vaccine Hesitancy and Uptake Among Vaccinated Population in Malaysia
Authors: Balakrishnan Vimala , Ayyasamy Ramesh Kumar , Alhashmi Saadat M.
Published: October 2024

This study identified the significant COVID-19 vaccine hesitancy and intention to uptake motives and sociodemographic predictors among vaccinated Malaysian adults. A cross-sectional study using a self-administered online questionnaire adapted from the COVID-19 Vaccine Hesitancy Scale and extended based on previous studies was used to solicit data from 698 Malaysians. A theoretical framework comprising Trust, Vaccine Concerns, Unreliable Entities, Uptake Influencers, Brand Influencers, and Brand_Side-effect was used as a guide to assess intention to receive COVID-19 vaccines in the future. Hierarchical linear regressions revealed Trust, Vaccine Concerns, Brand_Side-effect and Uptake Influencers to significantly predict intention to receive vaccines in the future when controlled for sociodemographic correlates. Ethnicity and technology literacy were found to have significant impacts on future vaccine uptake. Age significantly correlated with intention to be vaccinated as well. Underlying motives and sociodemographic correlates were identified for COVID-19 vaccine hesitancy and uptake.
Exploring the Link Between Social Media Adoption and Saudi Arabia SME’s Sustainable Performance: The Moderating Role of COVID-19
Authors: Alghamdi Omar A.
Published: October 2024

Small and medium-sized enterprises (SMEs) use social media to communicate effectively with stakeholders. However, little is known about the influence wielded by social media adoption on sustainable performance during COVID-19. Based on the technology–organization–environment (TOE) framework, our study developed an integrated model to explore the factors affecting social media adoption and its effect on sustainable performance in SMEs in the Saudi Arabian context. The quantitative method of a survey was used to collect data from SMEs owner-managers and CEOs. Partial least square was used to analyze data collected from 609 respondents. The findings revealed that environmental factors (i.e., the intensity of the competition, competitive pressure, and the bandwagon effect), technological factors (i.e., relative advantages and compatibility), and organizational factors have been the key drivers of social media adoption in SMEs during COVID-19. It also indicated that social media adoption is a key predictor of social, environmental, and economic sustainability. This study provides SMEs with meaningful implications about ways of fostering sustainable performance.
The Relationship Between Perceived Workplace Bureaucracies, Self-Efficacy and Job Motivation Over the COVID-19 Pandemic
Authors: Kang Janisha Kaur , Jiao Peng-De , Tay Jian-Hua , Gan Samuel Ken-En
Published: October 2024

Workplace bureaucracies impact many areas of an employee’s working life. High levels of perceived bureaucracy can diminish employees’ job motivation, satisfaction, and performance. During the COVID-19 pandemic, infection containment measures contributed significantly to the ‘great resignation’ via the lack of self-efficacy from perceived bureaucracy. This study surveyed 240 full-time employees between late 2021 and early 2022 across organizations in both private and public sectors in Singapore using the Work Extrinsic Intrinsic Motivation scale, the Workplace Bureaucracy questionnaire, and the General Self-Efficacy scale alongside demographic data collection. Results showed that salary range, education levels, self-efficacy and job motivation were negatively associated with perceived workplace bureaucracies but not gender, age, and length of employment. The study’s findings provide insight into the effect of increased perceived bureaucracy during the COVID-19 pandemic on employee experience that would be relevant to the workplace environment even in regular times as a possible intervention point for better employee experience.
Dental Hygienists’ Awareness of Medication-Related Osteonecrosis of the Jaw in Private Dental Clinics in Japan
Authors: Iijima Yosuke , Yamada Miki , Amano Mai , Watanabe Saya , Fujimaru Miki , Uematsu Ayako , Hino Shunsuke , Sano Motohiko , Horie Norio , Sakagami Hiroshi , Kaneko Takahiro
Published: October 2024

Purpose: Medication-related osteonecrosis of the jaw (MRONJ) caused by bisphosphonates (BPs) and denosumab (Dmab) is still a major oral adverse event caused by cancer treatment and may be under-recognized by private dental services. With the aim of reducing the prevalence of MRONJ, this study, which is a pilot study for a planned future large-scale survey, compared knowledge about MRONJ between dental hygienists (DHs) in private dental clinics and those in cancer center hospitals. Methods: We conducted a questionnaire-based survey regarding MRONJ between 1 November 2023 and 31 January 2024 on DHs at a cancer base hospital and a private clinic in Saitama, Japan. We statistically analyzed the data collected using the χ2 test or Fisher’s exact test with the level of significance set at 5%. Results: This study included 10 in-hospital and 53 private clinic DHs. The in-hospital DHs had appropriate knowledge of MRONJ. However, compared with the in-hospital DHs, although the private clinic DHs knew that BPs are used for osteoporosis, significantly fewer had knowledge of Dmab ( p < .001) or knew that BPs and Dmab could also be used to treat cancer (both p < .001). In addition, few private clinic DHs were aware of MRONJ cases refractory to antibiotic treatment alone ( p = .012). Conclusion: These findings suggest that private clinic DHs have less knowledge of MRONJ than those in cancer base hospitals.
Optical coherence tomography angiography to assess for retinal vascular changes in Neuro-Sjögren
Authors: Haar Melanie , Konen Franz Felix , Gehlhaar Marten A. , Oluwatoba-Popoola Irene , Donicova Emilia , Wachsmann Marija , Lubbad Ahmed , Hufendiek Katerina , Pielen Amelie , Hohberger Bettina , Mardin Christian , Gingele Stefan , Prenzler Nils K. , Ernst Diana , Witte Torsten , Framme Carsten , Skripuletz Thomas , Seeliger Tabea , Bajor Anna
Published: October 2024

Background:

Sjögren’s syndrome is an autoimmune disease characterized by sicca symptoms and various extraglandular manifestations including vasculitis. Neurological involvement occurs frequently (Neuro-Sjögren) and often mimics immune neuropathies such as chronic inflammatory demyelinating polyneuropathy (CIDP).

Objectives:

We aim to assess relevant differences in vessel density (VD) in Optical Coherence Tomography Angiography (OCTA) in those diseases to use it as an easily available diagnostic tool.

Design:

Prospective, monocentric pilot-study.

Methods:

OCTA (Heidelberg Engineering OCT SPECTRALIS) of the superficial vascular plexus, intermediate capillary plexus (ICP) and deep capillary plexus (DCP) of the retina was prospectively performed in Neuro-Sjögren, age-matched CIDP patients ( n = 31, each), and healthy controls ( n = 30). Vessel density (VD) and foveal avascular zone (FAZ) was measured with Erlangen Angio Tool.

Results:

Significantly lower VD were found for the DCP and ICP in Neuro-Sjögren and CIDP patients compared to healthy controls ( p = 0.0002 and <0.0001). When group comparison was age-adjusted, these differences were not found anymore. Different frequencies of “low” retinal blood flow in each layer comparing Neuro-Sjögren and CIDP patients were not found. FAZ revealed no significant differences between patients with Neuro-Sjögren, CIDP and healthy controls.

Conclusion:

This study found no significant differences in VD or the foveal avascular zone between Neuro-Sjögren and CIDP patients using OCTA, suggesting that inflammatory vascular changes in the retina are uncommon in Neuro-Sjögren patients.
Health Behavior Frameworks Describing HPV Vaccine Uptake in Adults: A Scoping Review
Authors: Oyedeji Oluwafemifola , Wisdom Taylor , Kintziger Kristina , Cernasev Alina , Hohmeier Kenneth , Hagemann Tracy , Gatwood Justin
Published: October 2024

Human papillomavirus (HPV) is the most prevalent sexually transmitted disease in the United States, and it has been shown to cause a number of different cancers, namely cervical. Fortunately, there is a highly efficacious vaccine that is available to adolescents and adults up to age 45. Vaccination rates in adults have increased over the years but are still low, especially in men. There is a need to understand HPV vaccine-seeking behaviors in adults to better address their concerns, beliefs, and barriers. The purpose of this scoping review is to provide a synthesis of the current literature on health behavior frameworks that have been used to describe HPV vaccine uptake in adults. This review also covers the socioeconomic barriers of adults getting the vaccine. For this review, 33 articles were found and included. The theory of planned behavior, health belief model, and social cognitive theory were the most commonly seen frameworks in the literature. Theoretical constructs that significantly predicted HPV vaccine behavior across the included studies were social norms, attitudes, perceived behavioral control, perceived benefits, perceived susceptibility, perceived severity, perceived barriers, and self-efficacy. Major socioeconomic factors that were described were provider recommendation, knowledge, age, gender, race, awareness, and marital status. This information is critical for public health efforts to better target the adult population with HPV vaccine information and awareness. It is also necessary for providers to better understand patients and their potential barriers to getting the HPV vaccine.