bluuebunny/crossref_metadata_2025 huggingface dataset:
A Bibliometric Analysis of COVID-19 across Science and Social Science Research Landscape
Authors: Aristovnik Aleksander , Ravšelj Dejan , Umek Lan
Published: June 2020

The COVID-19 pandemic caused by the novel coronavirus emerged in Wuhan City, Hubei province of China at the end of 2019, has radically transformed the lives of people around the world. Due to its fast spreading, it is currently considered as a worldwide health, social and economic concern. The lack of knowledge on this area has encouraged academic sphere for extensive research, which is reflected in exponentially growing scientific literature in this area. However, current state of COVID-19 research reveals only early development of knowledge, while a comprehensive and in-depth overview remains neglected. Accordingly, the main aim of this paper is to fill the aforementioned gap in the literature and provide an extensive bibliometric analysis of COVID-19 research across science and social science research landscape. The bibliometric analysis is based on the Scopus database including all relevant and latest information on COVID-19 related publications (n=10,344) in the January-May 2020 period. The findings emphasize an importance of a comprehensive and in-depth approach considering different scientific disciplines in COVID-19 research. The understanding of the evolution of emerging scientific knowledge on COVID-19 is beneficial not only for scientific community but also for evidence-based policymaking in order to prevent and address the COVID-19 pandemic.
Measuring the Resilience of Criminogenic Ecosystems to Global Disruption: A Case-Study of COVID-19 in China
Authors: Borrion Herve , Kurland Justin , Tilley Nick , Chen Peng
Published: June 2020

This paper uses resilience as a lens through which to analyse disasters and other major threats to patterns of criminal behaviour. A set of indicators and mathematical models are introduced that aim to quantitatively describe changes in crime levels in comparison to what could otherwise be expected, and what might be expected by way of adaptation and subsequent resumption of those patterns. The validity of the proposed resilience assessment tool is demonstrated using commercial theft data from the COVID-19 pandemic period. A 64 per cent reduction in crime was found in the studied city (China) during an 83-day period, before daily crime levels bounced back to higher than expected values. The proposed resilience indicators are recommended as benchmarking instruments for evaluating and comparing the global impact of COVID-19 policies on crime and public safety.
RepRapable Automated Open Source Bag Valve Mask-Based Ventilator
Authors: Petsiuk Aliaksei , Tanikella Nagendra G. , Dertinger Samantha , Pringle Adam , Oberloier Shane , Pearce Joshua
Published: June 2020

This study describes the development of an automated bag valve mask (BVM) compression system, which, during acute shortages and supply chain disruptions can serve as a temporary emergency ventilator. The resuscitation system is based on the Arduino controller with a real-time operating system installed on a largely RepRap 3-D printable parametric component-based structure. The cost of the system is under $170, which makes it affordable for replication by makers around the world. The device provides a controlled breathing mode with tidal volumes from 100 to 800 milliliters, breathing rates from 5 to 40 breaths/minute, and inspiratory-to-expiratory ratio from 1:1 to 1:4. The system is designed for reliability and scalability of measurement circuits through the use of the serial peripheral interface and has the ability to connect additional hardware due to the object-oriented algorithmic approach. Experimental results demonstrate repeatability and accuracy exceeding human capabilities in BVM-based manual ventilation. Future work is necessary to further develop and test the system to make it acceptable for deployment outside of emergencies in clinical environments, however, the nature of the design is such that desired features are relatively easy to add with the test using protocols and parametric design files provided.
Hesperidin and SARS-CoV-2: New Light on the Healthy Functions of Citrus Fruit
Authors: Bellavite Paolo , Donzelli Alberto
Published: June 2020

Among the many approaches to COVID-19 prevention, the possible role of diet has so far been somewhat marginal. Nutrition is very rich in substances with a potential beneficial effect on health and some of these could have an antiviral action or in any case be important in modulating the immune system and in defending cells from the oxidative stress associated with infection. This short review draws the attention on some components of Citrus fruits and especially of the orange (Citrus sinensis), well known for its vitamin content, but less for the function of its flavonoids. Among the latter, hesperidin has recently attracted the attention of researchers, because it binds to the key proteins of the SARS-CoV-2 virus. Several computational methods, independently applied by different researchers, showed that hesperidin has a low binding energy both with the coronavirus "spike" protein, and with the main protease that transforms the early proteins of the virus (pp1a and ppa1b) into the complex responsible for viral replication. The affinity of hesperidin for these proteins is comparable if not superior to that of common chemical antivirals. The preventive efficacy of vitamin C, at dosage attainable by diet, against viral infections is controversial, but recent reviews suggest that this substance may be useful in case of increased stress on the immune system. Finally, the reasons that suggest undertaking appropriate research on the Citrus fruits addition in the diet, as a complementary prevention and treatment of COVID-19, are discussed.
Low Cost High Intensity LED Illumination Device for High Uniformity Laboratory Purposes
Authors: D' Alessandro Carmine , De Maio Davide , Mundo Teresa , Musto Marilena , Di Giamberardino Franscesco , Monti Matteo , Dalena Davide , Palmieri Vittorio G. , De Luca Daniela , Di Gennaro Emiliano , Russo Roberto
Published: June 2020

Uniform illumination is a key requirement in different research fields. However, this requirement is often difficult to achieve when high intensity is required at the same time. Recent advancements in LED lamps allow nowadays for compact and economical solutions. In this work we present a suitable solution for various laboratory purposes requiring stable, uniform and high intensity illumination. The system is composed of four identical high power white LED arrays of 30 mm diameter each, placed on a supporting and cooling structure having a minimum volume of 26 cm x 26 cm x 8 cm. A numerical model has been developed, based on a ray tracing software, in order to simulate the performances. These have then been experimentally validated with measurements of the power density map, carried out with a 1% uncertainty pyranometer. Data show that the built system is very stable over time and provides an illumination uniformity higher than 98%, on a surface of 50 mm radius, which reduces to 95% on a surface of 75 mm radius. The power density can be adjusted in the 390-1360 W m-2 range, not affecting uniformity.
Investigating Potential Inhibitory Effect of Uncaria tomentosa (Cat's claw) against the Main Protease 3CLPro of SARS-CoV-2 by Molecular Modeling
Authors: Yepes-Pérez Andres F. , Herrera-Calderon Oscar , Sánchez-Aparicio José-Emilio , Tiessler-Sala Laura , Maréchal Jean-Didier , Cardona-G Wilson
Published: June 2020

COVID-19 is a novel severe acute respiratory syndrome coronavirus. Presently, there is no effective treatment for COVID-19. As part of the worldwide efforts to find efficient therapies and preventions, it has been reported the crystalline structure of the SARS-CoV-2 main protease Mpro (also called 3CLpro) bound to a synthetic inhibitor which represents a major druggable target. The druggability of Mpro could be used for discovering drugs to treat coronavirus disease 2019. It was carried out a multi-level computational study to evaluate the potential anti-viral properties of the components of the medicinal herb Uncaria tomentosa (Cat´s claw) focusing on the inhibition of Mpro. The in-silico approach starts with protein-ligand docking of 26 Cat’s claw key components followed by ligand pathway calculations, molecular dynamics simulations and MM-GBSA calculation of the free energy of binding for the best docked candidates. The structural bioinformatics approaches led to the identification of three bioactive compounds of Uncaria tomentosa (Speciophylline, Cadambine and Proanthocyanidin B2) with potential therapeutic effects by strong interaction with 3CLpro. Additionally, in silico drug-likeness indices for these components were calculated and show good predicted therapeutic profiles of these phytochemicals. Our findings suggest the potential effectiveness of Cat's claw as complementary and/or alternative medicine for COVID-19 treatment.
Platinum Nanoparticles for the Electrochemical Study of Heavy Metal ions Formed by the Sputtering Deposition of the ion beam Electrode
Authors: Alkhawaldeh Ahmad Khalaf
Published: June 2020

An electrochemical sensing platinum nanoparticle in the tantalum electrode is provided by means of an Ion Beam Sputtering Deposition (IBSD). The electrode was made with a Pt solution, sputtered simultaneously with hydrochloric acid corrosion on tantalum substrate. In the study of heavy metal ions, for example, the platinum nanoparticle electrodes as prepared were used Square wavelength voltammetry (OSWV) Hg2+, Cu2+ and Ag2+. The porous electrodes were observed in a broader range by the Pt nanostructure electrode for heavy metal ions. Furthermore, the susceptibility to detection has been shown to be saturated as the thickness of the layer electrode exceeded 50 nm. For Hg2+ 0,003-1 M, for Cu2+ 0,005-3 M and for Ag2+ the linear detection scale is 0,009-4 M. There has also been good reusability and repeatability. In addition, a scan electron microscope (SEM) used to study platinum electrode forming process and nanostructure. This electrode will have interesting applications in sensing systems.
Association of Maternal Iodine Intake with Congenital Hypothyroidism
Authors: Gopika P. , Sreelakshmi M. , Nalwaya Sajal , Bhyan Sarita Jangra
Published: June 2020

The iodine intake in a pregnant woman has been closely correlated with development of transient congenital hypothyroidism which leads to decline in neurocognitive abilities of the child later in life as the effects are very subtle at birth. Both low and excess ingestion of iodine has been found to contribute to this cause, although iodine deficiency is more commonly observed in women of underdeveloped nations. It poses risks not only to the foetus but also to the mother leading to obstetric complications such as still birth and spontaneous abortions. It can be prevented using WHO recommended daily iodine supplementation in deficient regions or decreasing the excess load in groups exposed to high iodine. Programmes designed to screen the new-born at birth can also help in improving the quality of life of the child. The deficient iodine condition is managed by administration of levothyroxine in dosage range of 10-15 mcg/kg/day. Generally, the prognosis of infants starting treatment early in life have a better neurocognitive outcome as compared to the treated infants late age at a later age. Avoidance of agents causing iodine exposure has resulted in decrease in the abnormal thyroid function levels.
Cross-Validated AdaBoost Classifier Used for Brain Tumor Detection
Authors: Dutta Shawni , Bandyopadhyay Samir
Published: June 2020

Brain Tumor is one of the severe diseases and occurrence of this disease threats human life. Detection of brain tumor in advance can secure patient’s life from unwanted loss. Well-timed and swift disease detection and treatment strategy can lead to improved quality of life in these patients. This paper attempts to use Machine Learning based ensemble approaches for recognising patients with brain tumor. Ensemble technique based AdaBoost classifier and 10-fold stratified cross-validation method are assembled in single platform is proposed in this paper for prediction of brain tumor. This prediction is compared against three baseline classifiers such as Gradient Boost, Random Forest and Extra Trees classifier. Experimental result implies the superiority of this model with an accuracy of 98.97%, f1-score of 0.99, kappa statistics score of 0.95 and MSE of 0.0103.
Maternal Mortality Ratio in Low Income Developing Countries-Focusing on Pakistan
Authors: Mehboob Riffat , Ahmad Fridoon Jawad , Gilani Syed Amir , Hassan Amber , Khalid Sidra , Akram Javed
Published: June 2020

Background: Maternal mortality (MM) is a matter of serious concern in low income developing countries (LDCs). Perspective: A great reduction has been observed regarding the maternal deaths globally after huge efforts since 1990 todate. However, the situation continues to be either stagnant or worsening in developing countries, suggesting that the efforts to cope with this issue are either insufficient or not properly implemented. We need to first diagnose the problem areas that are a great hurdle in the road to success towards the reduction of MM. Postpartum haemorrhage and preeclampsia are one of the most common causes of MM. Malnutrition, neurological dysfunction and cancer are among the non-obstetric causes. Trained medical and paramedical staff can be of great help in this regard by increasing awareness among masses at grass root level. Target set by Millennium Development goal has minimized the MM by 44%. But it has not met the target set by Millenium Development Goals 5 and a lot of measures need to be taken in this regard. Conclusions: Majority of the MDs are preventable and can be avoided by adopting appropriate frameworks, linked data sets, surveillance, birth attendants training, preparation for births, etc. Delay in decision to get healthcare, access to healthcare center and receiving these facilities are the main factors in MM.
In-Silico Analysis of Natural Products That Modulates Enzymes of Diabetic Target
Authors: Aryal Babita , Basnet Saroj , Marasini Bishnu P. , Khadayat Karan , Poudel Darbin Kumar , Lamichhane Ganesh , Budhathoki Prakriti , Niraula Purushottam , Dawadi Sonika , Marahatha Rishab , Phuyal Sitaram , Parajuli Niranjan
Published: June 2020

Metabolic enzymes are often targeted for drug development programs of metabolic diseases such as diabetes and its complications. Many secondary metabolites isolated from natural products have shown therapeutic action against these enzymes. However, some commercially available synthetic drugs have shown unfriendly impacts with various side effects. Thus, this research has focused on a comprehensive study of secondary metabolites showing better inhibitory activities towards metabolic enzymes such as α-amylase, α-glucosidase, aldose reductase, and lipase. Further receptor-based virtual screening was performed against the various secondary metabolites database designed in-silico. Using Gold combined with subsequent post-docking analyses, the score was obtained as methyl xestospongic ester (Gold score 65.83), 2,″4″-O-diacetylquercitrin (Gold score 65.15), kaempferol-3-O-neohesperidoside (Gold score 53.37) and isosalvianolic acid C methyl ester (Gold score 53.44) for lipase, aldol reductase, α-amylase, and α-glucosidase, respectively. Besides, vitexin and isovitexin for α-amylase; N-trans-Caffeoyl-tyramin for α-glucosidase; purpurolide F and schaftoside for lipase; acteoside and orientin for aldose reductase could be potential drugs for respective enzymes based on in-silico analyses, supported by experimental IC50 values reported. They could bind to the competitive sites of the various targets of metabolic enzymes, and finally, toxicity analysis using ProTox-II was also performed.
Airflow Characteristics Downwind a Naturally Ventilated Pig Building with a Roofed Outdoor Exercise Yard and Implications on Pollutant Distribution
Authors: Yi Qianying , Janke David , Thormann Lars , Zhang Guoqiang , Amon Barbara , Hempel Sabrina , Nosek Štěpán , Hartung Eberhard , Amon Thomas
Published: June 2020

The application of naturally ventilated pig buildings (NVPBs) with outdoor exercise yards is on the rise mainly due to animal welfare considerations, while the issue of emissions from the buildings to the surrounding environment is important. Since air pollutants are mainly transported by airflow, the knowledge on the airflow characteristics downwind the building is required. The objective of this research was to investigate airflow properties downwind of a NVPB with a roofed outdoor exercise yard for roof slopes of 5°, 15°, and 25°. Air velocities downwind a 1:50 scaled NVPB model were measured using a Laser Doppler Anemometer in a large boundary layer wind tunnel. A region with reduced mean air velocities was found along the downwind side of the building with a distance up to 0.5 m (i.e. 3.8 times building height), in which the emission concentration might be high. It was found that a smaller roof slope (i.e. 5° slope) resulted in a higher and shorter wake zone and thus a shorter air pollutant dispersion distance. It was concluded that a smaller roof slope could contribute to the dilution of air pollutants and a lower air pollutant concentration near the ground.
Experimental Characterization of Pantograph Arcs and Transient Conducted Phenomena in DC Railways
Authors: Mariscotti Andrea , Giordano Domenico
Published: June 2020

An electric arc is an example of a transient event that is quite common in electrified transportation systems as by-product of the current collection mechanism. As a broadband transient, an electric arc excites a wide range of (often oscillatory) responses related to the substation and onboard filters, as well as the line resonances and anti-resonances. Similarly do the charging of onboard filter and other related inrush events. This work considers the electrical characteristics of these transients and of the excited responses in order to define their typical spectral signatures in DC railways and take them into account concerning their impact on Power Quality measurements and the measurements of instruments deployed onboard.
Evaluation of the results of regional metrology organisation comparisons and national inter-laboratory comparisons for electrical quantities
Authors: Velychko Oleh , Gordiyenko Tetyana , Karpenko Stanislav
Published: June 2020

The global metrological traceability fully depends on the implementation of international mutual recognition agreements in field of metrology. The linked results of international comparisons of national standards for alternating current/direct current (AC/DC) voltage transfer difference measurements and electrical power measurements, and national inter-laboratory comparison AC/DC voltage transfer difference and electrical power measurements at industrial frequency was presented. The main goal of this inter-laboratory comparison was the assessment of calibration laboratories capabilities that perform calibration in AC/DC voltage transfer difference and electrical power measurements. The consistency of the data obtained using the En numbers and Chi² test was estimated.
Research trends and challenges on DAC testing
Authors: Balestrieri Eulalia , Daponte Pasquale , De Vito Luca , Picariello Francesco , Rapuano Sergio , Tudosa Ioan
Published: June 2020

Today a very wide range of different applications relies on the Digital to Analog Converters (DACs). Different DAC architectures have been developed in the years and several different specifications exist to quantify their effective performance, essential information to verify the requirement fulfilling and the DAC suitability for the specific application.  As a result, DAC testing has assumed and continues to assume increasing importance. Main testing challenges include the reduction of the test time and cost, the measurement uncertainty computation and facing with the emerging Built-In Self-Test (BIST) solutions. To unambiguously clarify DAC terms, definitions and test methods the IEEE Std. 1658 has been developed and is currently under revision. To highlight the trends and issues also providing useful information for the revision of the standard, the paper presents an overview of the recent research work dealing with the DAC testing.

 
Detectable HIV-RNA Viral Load Among HIV-Infected Pregnant Women on Treatment in Northern Uganda
Authors: Napyo Agnes , Tumwine James K , Mukunya David , Tumuhamye Josephine , Arach Anna Agnes Ojok , Ndeezi Grace , Waako Paul , Tylleskär Thorkild
Published: June 2020

Background / Objectives: Detectable HIV viral load among HIV-infected pregnant women remains a public health threat. We aimed to determine factors associated with detectable viral load among HIV-infected pregnant women in Lira, Northern Uganda.

Methods: We conducted a cross-sectional survey among 420 HIV-infected pregnant women attending Lira Regional Referral Hospital using a structured questionnaire and combined it with viral load tests from Uganda National Health Laboratories. We conducted multivariable logistic regression while adjusting for confounders to determine the factors associated with detectable viral load and we report adjusted odds ratios and proportion of women with viral load less than 50 copies/ml and above 1000 copies, respectively.

Results: The prevalence of detectable viral load (>50 copies/ml) was 30.7% (95%CI: 26.3% - 35.4%) and >1000 copies/ml was 8.1% (95% CI: 5.7% – 11.1%). Factors associated with detectable viral load were not belonging to the Lango ethnicity (adjusted odds ratio = 1.92, 95%CI: 1.05 – 3.90) and taking a second-line (protease inhibitor-based) regimen (adjusted odds ratio = 4.41, 95%CI: 1.13 – 17.22).

Conclusions and Global Health Implications: HIV-infected pregnant women likely to have detectable viral load included those taking a protease inhibitor-based regimen and those who were not natives of Lira. We recommend intensified clinical and psychosocial monitoring for medication compliance among HIVinfected pregnant women that are likely to have a detectable viral load to significantly lower the risk of vertical transmission of HIV in Lira specifically those taking a protease inhibitor-based regimen and those who are non-natives to the study setting. Much as the third 90% of the global UNAIDS 90-90-90 target has been achieved, the national implementation of PMTCT guidelines should be tailored to its contextual needs.

Key words: • HIV • Women • Pregnancy • Pregnant women • Viral load • Viral suppression • PMTCT • Antiretroviral therapy • Uganda

 

Copyright © 2020 Napyo et al. Published by Global Health and Education Projects, Inc. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY 4.0) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work, first published in this journal, is properly cited.
Formation of Anorthositic Rocks within the Blair River Inlier of Northern Cape Breton Island, Nova Scotia (Canada)
Authors: Shellnutt J. Gregory , Dostal Jaroslav , Keppie J. Duncan , Keppie D. Fraser
Published: June 2020

Rocks from the Blair River inlier of Northern Cape Breton Island (Nova Scotia, Canada) have been correlated with either the Grenville basement of eastern Laurentia or the accreted Avalon terrane. Additional zircon U-Pb dates of spatially associated anorthositic dykes (425.1±2.2 Ma) and a metagabbro (423.8±2.5 Ma) from the Fox Back Ridge intrusion of the Blair River inlier reveal Late Silurian emplacement ages. Their contemporaneity suggests that they may be members of a larger intrusive complex. The anorthositic rocks have high Eu/Eu∗ values (>2.5), and bulk compositions are similar to the mineral compositions of labradorite (An50-70) and andesine (An30-50). The metagabbro is compositionally similar to alkali basalt and does not seem to have been affected by crustal contamination (Nb/U>24; Th/NbPM≤1.1) although it was metamorphosed. The high Tb/YbN (1.8-1.9) ratios suggest that the parental magma of the metagabbro was derived from a garnet-bearing peridotite. Fractional crystallization and mass balance calculations indicate that the anorthositic rocks can be derived by mineral accumulation from a mafic parental magma similar in composition to the metagabbro of this study. The Late Silurian ages suggest that the rocks were emplaced into the Avalon terrane after the closure of the Iapetus Ocean but before Early Devonian (415-410 Ma) sinistral transpression.
ANALISIS KESETARAAN GENDER PADA PEMBELAJARAN PROGRAM KEAHLIAN TEKNIK DI SMK PGRI 2 PONOROGO
Authors: Werdiningsih Wilis
Published: June 2020

Kesetaraan dan keadilan gender harus diwujudkan dalam segala aspek kehidupan, termasuk dalam kegiatan pendidikan. Pendidikan responsif gender penting untuk diterapkan di seluruh lembaga pendidikan, sebab baik laki-laki maupun perempuan adalah sama dan berhak untuk memperoleh segala manfaat dalam pendidikan sesuai dengan minat dan bakatnya. SMK PGRI 2 Ponorogo merupakan salah satu sekolah kejuruan di Ponorogo dengan jumlah siswa perempuan yang minoritas.Perempuan sering kali dianggap lebih banyak memiliki kelemahan di dalam kegiatan praktik dibandingkan laki-laki.Penelitian ini bertujuan untuk menganalisis kesetaraan dan keadilan gender pada pembelajaran program keahlian teknik di SMK PGRI 2 Ponorogo.Pendekatan yang digunakan dalam penelitian ini adalah pendekatan kualitatif dengan jenis studi kasus. Sumber data berasal dari kata-kata, tindakan, sumber tertulis dan foto yang berkaitan dengan proses kegiatan pembelajaran jurusan teknik di SMK PGRI 2 Ponorogo. Hasil menunjukkan bahwa kesetaraan dan keadilan gender di SMK PGRI 2 Ponorogo telah terwujud. Dalam kegiatan pembelajaran, baik siswa perempuan maupun laki-laki, mendapatkan akses yang sama, kesempatan untuk berpartisipasi, memiliki kontrol dan dapat mengambil manfaat secara maksimal.Namun masih terjadi ketidaksetaraan gender, yakni pada kategori pelabelan, subordinasi dan pemiskinan. [Gender equality and justice are must be realized in all aspects of life, including educational activities. Gender responsive education is important to be implemented in all educational institutions, because both men and women are the same and are entitled to get all the benefits in education in accordance with their interests and talents. SMK PGRI 2 Ponorogo is one of the vocational schools in Ponorogo with a number of minority female students. Women are often considered to have more weaknesses in practical activities than men. This study aims to analyze gender equality and justice in learning technical skills programs at SMK PGRI 2 Ponorogo. The approach that used in this research is a qualitative approach with the type of case study. The source of the data comes from words, actions, written sources and photos that are all forms of data relating to the process of learning activities in the engineering department at SMK PGRI 2 Ponorogo. The results show that gender equality and justice in SMK PGRI 2 Ponorogo have been realized. In learning activities, both female and male students get equal access, the opportunity to participate, have control and can take maximum advantage. However, there is still a gender inequality, namely in the categories of labelling, subordination and impoverishment.]
Capacitação para técnicos e gestor da Diretoria de Vigilância Epidemiológica (DIVE) do estado de Santa Catarina
Authors: Matiola Cleusa
Published: June 2020

A capacitação aos técnicos e gestores da DIVE foi escolhida como produto deste estudo e teve como tema: A avaliação dos elementos climáticos, socioeconômicos e sua relação com o A. aegypti, nos municípios de Chapecó/SC e Itajaí/SC. O número de focos de A. aegypti é significativo no estado de Santa Catarina ao longo dos anos. Esse mosquito transmite zika vírus, febre chikungunya e a dengue, que tem sido um dos principais problemas de saúde pública. A capacitação promove a atualização técnica e reflexiva, a avaliação dos processos de gestão e execução das ações. Como produto deste trabalho, a capacitação teve como objetivo apresentar a metodologia aplicada ao trabalho, as dificuldades de manipulação dos dados de endereços e os resultados obtidos. A metodologia apresentada, pode ser aplicada a outros municípios e implantada como ferramenta que relaciona dados, as dificuldades de trabalho com os endereços sugerem adequações no cadastro dos dados, e os resultados obtidos auxiliam na discussão de estratégias de prevenção, controle e combate aos focos.
Use of a New Thermodynamics-Based Saturation/Pressure Relationship in Two-Phase Rate-Transient Analysis of Boundary-Dominated Gas/Condensate Reservoirs
Authors: Sun Qian , Ayala Luis F.
Published: June 2020

Considerable research has been focused on the development of rate-transient-analysis (RTA) models to estimate the reserves of gas/condensate reservoirs. Currently, broadly deployed RTA tools rely on multiphase pseudopressure concepts to enable multiphase production-data analysis. In any multiphase pseudopressure calculation, the determination of the saturation/pressure (So/p) relationship plays a vital role because it directly influences the ability of multiphase RTA methods to reliably forecast original gas in place (OGIP). In this work, we present a thermodynamics-based So/p model that provides a better understanding of the phase behavior for the boundary-dominated gas/condensate reservoirs. The proposed So/p model is derived from the thermodynamic nature of extended black-oil formulations. A noniterative flash-calculation protocol is used to establish the So/p path in the condensate-buildup region. The developed method can be coupled with RTA tools and services for the calculation of multiphase pseudopressure. In this work, we present case studies of three gas/condensate reservoirs with different types of fluids. Two RTA multiphase analysis models are used to scrutinize the production data using the newly proposed So/p relationship, and results are compared with the use of a traditional steady-state method coupled with constant-volume-depletion (CVD) data. Results of the case studies show that RTA models that use the proposed So/p consistently yield more accurate OGIP estimation. Thus, this work presents a practical approach to remove commonly used yet potentially faulty assumptions in multiphase RTA applications for liquid-rich gas/condensate reservoirs.
Understanding Family Caregivers’ Needs to Support Relatives with Advanced Progressive Disease at Home: An Ethnographic Study in Rural Portugal
Authors: Teixeira Maria Joao Cardoso , Abreu Wilson , Costa Nilza , Maddocks Matthew
Published: June 2020

Background: Family caregivers play an important role supporting their relatives with advanced progressive disease to live at home. There is limited research to understand family caregiver needs over time, particularly outside of high-income settings. The aim of this study was to explore family caregivers’ experiences of caring for a relative living with advanced progressive disease at home, and their perceptions of met and unmet care needs over time. Methods: An ethnographic study comprising observations and interviews. A purposive sample of 10 family caregivers and 10 relatives was recruited within a rural area in the north of Portugal. Data were collected between 2014-16 using serial participant observations (n=33) and in-depth interviews (n=11). Thematic content analysis was used to analyse the data. Results: Five overarching themes were yielded: (1) provision of care towards independence and prevention of complications; (2) perceived and (3) unknown caregiver needs; (4) caregivers’ physical and emotional impairments; and (5) balancing limited time. An imbalance towards any one of these aspects may lead to reduced capability and performance of the family caregiver, with increased risk of complications for their relative. However, with balance, family caregivers embraced their role over time. Conclusions: These findings enhance understanding around the needs of family caregivers, which are optimally met when professionals and family caregivers work together with a collaborative approach over time. Patients and their families should be seen as equal partners. Family-focused care would enhance nursing practice in this context and this research can inform nursing training and educational programs.
WHO Trial Registration Data Set (TRDS) Extension for Traditional Chinese Medicine 2020: Recommendations, Explanation, and Elaboration
Authors: Zhang Xuan , Lan Liang , Chan Jacky CP , Zhong Linda LD , Cheng Chung-Wah , Lam Wai-Ching , Tian Ran , Zhao Chen , Wu Tai-Xiang , Shang Hong-Cai , Lyu Ai-Ping , Bian Zhaoxiang
Published: June 2020

Background: Although the WHO Trial Registration Data Set (TRDS) has been published for many years, the quality of clinical trial registrations with traditional Chinese medicine (TCM) is still not satisfactory, especially about the inadequate reporting on TCM interventions. The development of the WHO TRDS for TCM Extension 2020 (WHO TRDS-TCM 2020) aims to address this inadequacy. Methods: A group of clinical experts, methodologists, epidemiologists, and editors has developed this WHO TRDS-TCM 2020 through a comprehensive process, including the baseline survey, draft of the initial items, three-round of Delphi survey, solicitation of comments, revision, and finalization. Results: The WHO TRDS-TCM 2020 statement extends the latest version (V.1.3.1) of TRDS published in November 2017. The checklist includes 11 extended items (including subitems), namely Source(s) of Monetary or Material Support (Item 4), Scientific Title (Item 10a and 10b), Countries of Recruitment (Item 11), Health Condition(s) or Problem(s) Studied (Item 12), Intervention(s) (Item 13a, 13b and 13c), Key Inclusion and Exclusion Criteria (Item 14), Primary and Key Secondary Outcomes (Item 19 to 20), and Lay Summary (Item B1). For Item 13 (Interventions), three common TCM interventions--i.e., Chinese herbal medicine formulas, acupuncture and moxibustion—are elaborated. Conclusions: The group hopes that the WHO TRDS-TCM 2020 can improve the reporting quality and transparency of TCM trial registrations, assist registries in assessing the registration quality of TCM trials, and help readers understand TCM trial design.
Decoding and Reasoning Mental States in Major Depression and Social Anxiety Disorder
Authors: Maleki Gheysar , Zabihzadeh Abbas , Richman Mara J. , Demetrovics Zsolt , Mohammadnejad Fatemeh
Published: June 2020

Background: Major depression (MDD) and social anxiety (SAD) disorders are debilitating psychiatric conditions characterized by disturbed interpersonal relationships. Despite these impairments in social relationships, research has been limited in simultaneously evaluated the dysfunction in MDD or SAD within two aspects of theory of mind (ToM): decoding mental states (i.e., Affective ToM) and reasoning mental states (i.e., cognitive ToM). Taking this into consideration, the current study assesses both decoding and reasoning mental states abilities in MDD, SAD, and healthy controls (HC). Methods: Subjects included 37 patients with MDD, 35 patients with SAD, and 35 HCs. ToM was measured with the Reading the Mind in the Eyes Test (RMET) and the Faux Pas Task, which assess decoding and reasoning mental states, respectively. Results: Results revealed that in decoding of mental states, both the SAD and MDD groups had lower scores than the HC group; there was no significant difference between the SAD and MDD groups in decoding mental states. Conversely, in reasoning mental states, the SAD and HC groups had higher scores than the MDD group; no differences were found between the SAD and HC groups. Conclusions: Clinicians and researchers should further consider parsing generalized impairment in ToM into two aspects: decoding and reasoning of mental states by using the aforementioned measurements. By further understanding the two aspects, we can create a potentially new clinical profile for mental health disorders, such as in this context with both decoding and reasoning mental state impairment in MDD and a reasoning dysfunction in SAD.
Oncologic results in rectal cancer patients with a subcentimeter distal margin after laparoscopic-assisted sphincter-preserving surgery: a propensity-score matched cohort analysis
Authors: Zhang Chenghai , Yang Hong , Cui Ming , Xing Jiadi , Yao Zhendan , Tan Fei , Zhang Nan , Chen Lei , Liu Maoxing , Xu Kai , Su Xiangqian
Published: June 2020

Background: Distal resection margin (DRM) is closely associated with sphincter-preserving surgery and oncologic safety for patients with mid-low rectal cancers. However, the optimal DRM has not been determined. The purpose of this study to assess the impact of a DRM of ≤ 1 cm on oncologic safetyMethods: Data of 378 rectal cancer patients who underwent laparoscopic-assisted sphincter-preserving surgery from 2009 to 2015 were retrospectively analyzed. Patients were divided into two groups based on DRM: ≤ 1 cm (n=74) and >1 cm (n=304). To minimize the differences between the two groups, propensity-score matching on baseline features was performed. Stratified analysis was performed according to neoadjuvant chemoradiotherapy.Results: Before propensity-score matching, no significant differences in 5-year disease-free survival (DFS) (92.8 vs. 81.3%; P=0.128) and 5-year overall survival (OS) (83.7 vs. 82.2%; p=0.892) were observed in patients with DRMs of ≤1(n=74) and >1cm (n=304), respectively. After propensity-score matching (1:1), there were also no significant differences in DFS (88.1 vs. 78.2%; P=0.162) and OS (84.5vs. 84.9%; P=0.420) between the DRM of ≤1 cm group (n=65) and >1 cm group (n=65), respectively. A total of 44 patients received preoperative chemoradiotherapy. In this cohort, the 5-year local recurrence (LR) rates ( p=0.118) and the 5-year DFS rates ( p=0.298) were not significantly different between two groups. A total of 334 patients received surgery without neoadjuvant chemoradiotherapy. There were also no significant differences in the 5-year LR rates ( p=0.150) and 5-year DFS rates ( p=0.172) between two groups.Conclusions: No matter whether patients with rectal cancers receiving neoadjuvant therapy or not, sphincter-preserving surgery with a DRM of ≤1 cm may be acceptable in mid-low rectal cancer without jeopardizing oncologic safety.
Genetic Engineering of Pseudomonas Chlororaphis Lzh-T5 to Enhance Production of Trans-2,3-Dihydro-3-Hydroxyanthranilic Acid
Authors: Li Ling , Li Zhenghua , Zhang Xuehong , Wang Wei , Huang Yujie , Wang Ruiming , Wang Tengfei , Liu Kaiquan
Published: June 2020

The authors have withdrawn this preprint due to erroneous posting.
MicroRNA Expression Signature and Target Prediction in Familial and Sporadic ACTH-Independent Macronodular Adrenal Hyperplasia
Authors: Xiaogang Tan , Zhu Jie , Liang Cui
Published: June 2020

Background: ACTH independent macronodular adrenal hyperplasia (AIMAH) is a rare disorder characterized by bilateral macronodular hyperplasia of the adrenal glands and increased cortisol production with subclinical or overt Cushing's syndrome. To screen and analyze the microRNA profile of AIMAH, so as to elucidate the possible pathogenesis of the disease. Methods: MiRNA microarray was used to test the tissue samples from familial AIMAH patients, sporadic AIMAH patients and normal controls of other non-tumor adrenocortical tissues, to identify characteristic microRNAs expression signatures. Some miRNAs were validated by RT-PCR. Furthermore, the key signal pathways and miRNAs involved in AIMAH pathogenesis were analyzed by gene ontology and pathway analysis.Results: Characteristic microRNA expression signatures were identified for familial AIMAH patients including 16 differentially expressed microRNAs and sporadic AIMAH patients including 8 differentially expressed microRNAs respectively. RT-PCR assay confirmed the chosed miRNAs expression, suggesting the high reliability of miRNA array. Pathway analysis showed that the most enriched pathway was renal cell carcinoma pathway. Overexpression of miR-17，miR-20a and miR-130b can inhibit glucocorticoid-induced apoptosis in the AIMAH pathogenesis.Conclusion: We have identified the miRNA signature in in Familial and Sporadic AIMAH patients, The differentially expressed miRNAs may be involved in the mechanisms of AIMAH pathogenesis. Specific miRNAs, such as miR-17，miR-20a and miR-130b may be new potential targets for further functional studies of AIMAH.
Cytological Effects of Herbicidal and Fungicidal Pesticides on Root Apex Meristem Cells of Triticum Aestivum
Authors: Menzyanova Natalia , Shishatskaya Ekaterina , Pyatina Svetlana , Volova Tatiana
Published: June 2020

Using the example of 2-day-old Triticum aestivum seedlings, grown in hydroponic culture, the cytological effects of pesticides with various mechanisms of the damaging were studied: the herbicides metribuzin, tribenuron-methyl, fenoxaprop-P-ethyl and the fungicides tebuconazole, epoxiconazole, and azoxystrobin. All pesticides showed a dose-dependent inhibitory effect on the development of the roots of Triticum aestivum, but did not affect the mitotic activity and did not reduce the mitotic index of root apex meristem cells. Herbicides and fungicides affected the duration of metaphase, anophase, prophase, and cytokinesis activity in the root apex meristem of the wheat, and these changes were specific for the six studied preparations. Under the influence of all pesticides, the number of abnormal cells increased significantly, to the greatest extent (10–12 times compared with control - distilled water) under the influence of herbicides tribenuron-methyl and phenoxaprop-ethyl and fungicides azoxystrobin and epoxiconazole; to a lesser extent - under the influence of metribuzin and tebuconazole (6–7 times). For all studied pesticides the manifestation of cyto- and genotoxicity, including both clastogenic and aneugenic effects, was revealed in relation to the non-target plant Triticum aestivum. Under the influence of pesticides, structural anomalies, caused by chromosome breakdown (bridges, fragments, micronuclei) and spindle damage (lagging chromosomes and their fragments, uneven chromosome separation) were detected in the cells of the Triticum aestivum root apex meristem.
Intravenous Thrombolysis after Reversal of Dabigatran with Idarucizumab in Acute Ischemic Stroke: A Case Report
Authors: XIE DAN , Wang Xuefan , Li Yao , Chen Ruiling , Zhao Yingying , Xu Chunling , Zhang Qian , Zhang Yongbo
Published: June 2020

Background: As there is a growing concern about the cerebral embolism events secondary to non-valvular atrial fibrillation, direct oral anticoagulant (DOAC) has been more and more widely used as an anticoagulation treatment for prevention of stroke. However, in the face of life-threatening bleeding or emergency surgery/treatment, doac-related antagonists such as idarucizumab need to be urgently used to reverse the DOAC. Using rt-PA intravenous thrombolysis for acute ischemic stroke requires a time window of 4.5 hours. This case reports rt-PA intravenous thrombolysis after reversal of dabigatran anticoagulation with idarucizumab in patients with acute ischemic stroke. Case presentation: We report the case of 62-year-old Chinese female with nonvalvular atrial fibrillation treated with dabigatran 110mg twice daily, and missed a dose on the eve of the stroke. The patient presented with acute ischemic stroke causing the angle of mouth deviated to right side and left limb weakness in the early morning of the next day. Due to the last dosing time of dabigatran was between 24-48 hours, the patients were given rt-PA intravenous thrombolysis after reversal of dabigatran anticoagulation with idarucizumab, while all contraindications had been excluded by laboratory test and CT scan. NIHSS score was reduced from 4 to 1, and the patient was discharged after 2 weeks. Conclusion: Our case report adds to the evidence that idarucizumab administration is safe and effective in the setting of patients with atrial fibrillation treated with dabigatran who develop acute ischemic stroke requiring rt-PA intravenous thrombolysis.
Between Tales, Myths And Mysteries: Beliefs and Superstitions of A Quilombola Community From The Countryside of Northeastern Brazil
Authors: MACÊDO ERMÍNIA MEDEIROS , Barros Roseli Farias de Melo , Figueiredo Luciano Silva , Batista Márcio Luciano Pereira
Published: June 2020

Background: Tales, myths, beliefs and superstitions are part of the daily life of traditional communities, which strongly believe in the interference of both natural forces and activities, as well as supernatural ones in their social manifestations. Whether in the imaginary facts or real situations experienced by residents, this set of relationships and symbolisms underlie the cosmology of that social group, through which it is possible to identify traces of the cultural and identity constitution of a people. In quilombola communities, the recurrence of these cultural elements is a common practice. In this perspective, the objective was to recognize the tales, myths, beliefs and superstitions of the Quilombola Custaneira/Tronco community in the state of Piauí, as instruments for reaffirmation and strengthening of traditional knowledge and local culture. Method: The methodological path was based on the ethnographic approach and the life history through semi-structured interviews with 23 residents, being older or living longer in the locality. Results: By entering the cosmological universe of the Custaneira/Tronco community and accessing the accounts involving their tales, myths, beliefs and superstitions, we can identify, as in other quilombola communities, the presence of three worlds: the dead, the living and the enchanted.Conclusions: The conclusive aspects point out that the tales, myths, beliefs and superstitions, like the “Father of the Forest”, the visions and the “Mother of Water”, greatly influence the social and cultural practices of the community, especially in hunting rituals, in the relationship with animals and with local natural resources. The cosmological arrangement performs functions that organize its social structure and maintain the connection with its ancestors and its traditionality.
Land Cover Dynamics (from 1986 to 2015) and its Relation with Area Closure and Slope in Hita-Borkena Watershed, Northeastern Ethiopia
Authors: Ayele Alemayehu Assefa , Yimer Assefa Abegaz , Mini Simphiwe E.
Published: June 2020

Background: Land cover dynamics take place as a result of the integration of both physical and man-made factors. This situation is common in Ethiopia and in the study watershed as well. The study was intended to assess the land cover dynamics through 1986 – 2015 and to identify its relation with slope and landscape restoration that incorporates area closure. The analysis was made based on the interpretation of satellite images. Methods: Both ERDAS IMAGINE 9.1 and ARC GIS 10.3 software were employed in order to generate land cover maps of the study area from satellite images. Also, slope map of the study area was processed from DEM of Ethiopia. Results: The study found out that forestlands and shrublands shrunk through 1986 – 2015, grasslands expanded mainly due to the implementation of landscape restoration including area closure since 2001. Cropland expanded remarkably. Similarly, the coverage of bareland and settlement also increased. Conclusions: Based on the results of the study, it is concluded that similar restoration activities shall be implemented in similar environments in Ethiopia to keep the natural resources, and the vegetation cover of Hita-Borkena watershed shall be improved.