bluuebunny/crossref_metadata_2025 huggingface dataset:
A simulation framework for reciprocal recurrent selection-based hybrid breeding under transparent and opaque simulators
Authors: Zhang Zerui , Wang Lizhi
Published: June 2023

Hybrid breeding is an established and effective process to improve offspring performance, while it is resource-intensive and time-consuming for the recurrent process in reality. To enable breeders and researchers to evaluate the effectiveness of competing decision-making strategies, we present a modular simulation framework for reciprocal recurrent selection-based hybrid breeding. Consisting of multiple modules such as heterotic separation, genomic prediction, and genomic selection, this simulation framework allows breeders to efficiently simulate the hybrid breeding process with multiple options of simulators and decision-making strategies. We also integrate the recently proposed concepts of transparent and opaque simulators into the framework in order to reflect the breeding process more realistically. Simulation results show the performance comparison among different breeding strategies under the two simulators.
The SARS-CoV-2 vaccination rate and hesitation in Shanghai older adults with dementia
Authors: Yang Yang , Nie Jing , Sun Fei , Wang Jinghua , Chen Jianhua , Li Ling , Sheng Meiqing , Yang Sijie , Yu Lei , Li Xia
Published: June 2023

Background

Older adults, particularly those with dementia, are at the greatest risk for being affected by SARS-CoV-2. Despite the Chinese government’s efforts to encourage older adults to receive SARS-CoV-2 vaccines, the vaccination rate, especially among older adults with dementia, remains low.

Objective

This study aimed to examine the willingness and attitudes towards vaccination among guardians of older adults with dementia and to uncover the factors that may have influenced attitudes towards vaccination during the 2022 Omicron Variant of SARS-CoV-2 outbreak in Shanghai, China.

Methods

We conducted a cross-sectional study using self-administered anonymous questionnaires to guardians of dementia patients in three settings: psychogeriatric inpatient wards, long-term care facilities, and home settings from April to May 2022. The primary outcome was participants’ willingness to allow dementia patients to receive SARS-CoV-2 vaccines. Logistic regression analyses were used to identify factors associated with vaccination willingness.

Results

A total of 327 valid questionnaires were collected. The vaccination rate among participants from long-term care facilities (12.9%) was lower than those in the psychiatric ward (19.3%) or community-dwelling settings (27.1%) (p < 0.05). The guardians’ primary concern was that vaccination would aggravate the health conditions of dementia patients [adjusted odds ratio (OR) = 5.11; 95% confidence interval (CI): 1.86–14.05]. Additionally, negative reports about the vaccination [OR = 3.94; 95% CI: 1.68–9.24], and adverse reactions [OR = 2.50; 95% CI: 1.13–5.52] were related to higher odds of vaccine hesitancy.

Conclusion

Our results showed that low vaccination rates in older adults with dementia were mainly due to their guardians’ concerns about vaccine safety. Our findings first uncovered the actual SARS-CoV-2 vaccination rates among older adults with dementia and may provide potential interventions to reduce unjustified worries towards vaccination.
End-stage care for children after heart transplant
Authors: Everitt Melanie D.
Published: June 2023

Heart transplant is performed annually in over 600 children worldwide to treat life-limiting cardiac disease. Conversations regarding waitlist mortality, post-transplant morbidity and mortality, and goals of care are commonplace pre-transplant. However, there is a void of information and resources for providers and families when end-stage disease recurs in the long-term transplant recipient. The purpose of this review is to discuss the care of the pediatric heart transplant recipient with chronic cardiac dysfunction occurring years after a successful transplant. This includes a need for transplant providers to have education and training related both to palliative care and medical ethics to improve shared decision making with patients and families.
How Supermassive Black Holes Shape Galaxies
Authors: Lü Ying-He Celeste , Diamante Letizia
Published: June 2023

We often think of black holes as mysterious objects that swallow everything that passes by them—from dust to entire stars. In reality, black holes “eat” in a messy way, while spinning around super quickly. They do not swallow their whole “meal” (such as interstellar gas and dust) in a mouthful. Part of it rotates around the spinning black hole, like a merry-go-round, and is eventually thrown outward as very bright, energetic streams of particles called jets. Supermassive black holes the centers of galaxies can create jets that travel very far and affect the birth of baby stars! In this article, we will describe some of the things we know about black holes, including how astronomers found out about black hole jets using powerful telescopes. We will also mention some of the things we still do not understand about black holes and their jets.
Analysis on Coupling Coordination Degree for Cropland and Livestock from 2000 to 2020 in China
Authors: Chen Jianxing , Gao Xuesong , Zhang Yanyan , Penttinen Petri , Wang Qi , Ling Jing , Lan Ting , Ou Dinghua , Li Yang
Published: June 2023

The decoupling of cropland and livestock due to the industrialization of livestock production is a difficult problem for sustainable agricultural development in many global locations, including China. As population and urbanization increase, this decoupling is likely to become more serious. To date, the relationship between cropland and livestock has been mainly studied from a single perspective, and mostly at the regional and the local scales. Thus, the objective of our study is to systematically assess the coupling relationship between cropland and livestock from multiple aspects on a large scale. Here, we used a complex system covering cropland, livestock and environment subsystems to comprehensively analyze the spatio-temporal variation of the coupling coordination between cropland and livestock and its influencing factors in China over the past two decades. Elaborating on the data, we constructed a comprehensive system of evaluation indexes for cropland–livestock systems. We used a coupling coordination degree model to evaluate the coupling coordination relationship between cropland and livestock in 31 provinces of China during 2000–2020. The results show that the range of cropland–livestock and cropland–livestock–environment coupling coordination degree was 0.4–0.9. In most of the provinces, there was no risk of cropland and livestock decoupling; however, the coupling coordination degree needed to be increased. More attention should be paid to the coordinated development of cropland and livestock coupling in urbanized areas such as Beijing and Tianjin, where cropland and livestock decoupling was more likely to occur. Among the assessed 29 factors, 15 and 16 had an impact on the cropland–livestock and the cropland–livestock–environment coupling coordination degrees, respectively. Our study provides science-based evidence to support estimating the coupling relationship between cropland and livestock in the future.
Prospection of Cellulolytic Fungi from Composted Samples of Saturated Horse Litter
Authors: Nascimento Ana Gabriela C. R. do , Paula Alessandra M. de , Busato Jader G. , Silva Samia G. da , Texeira Neto Antonio Raphael
Published: June 2023

The treatment of saturated horse beds before they arrive at their final destination is necessary to avoid the risk of animal and environmental contamination. For this purpose, the composting process has great functionality due its to low cost, effectiveness, and operational ease. However, because of the nature of the materials used, this process can be long, and it is necessary to improve it to optimize composting cycles. This work aimed to isolate and identify fungi present in the compost piles of saturated equine bedding made with shavings and rice straw, identifying those with the greatest potential for cellulase production. Using specific cellulolytic media containing shavings or rice straw, seven strains were isolated. The total cellulase enzymatic activity of the isolates from the beds made with shavings was lower than that obtained from rice straw beds. Four strains showed high enzymatic potential for use in the shavings substrate (MA -6 2 f1, MA -6 2 f2, MA -7 9, and MA -7 10) and three for the rice straw substrate (PA -7 5, PA -7 7, and PA -7 10). The isolate PA -7 5 reached 0.376 IU mL−1, the best index among all the isolates. These isolates were identified as belonging to the Aspergillus fumigatus species.
Pottery Impressions Reveal Earlier Westward Dispersal of Foxtail Millet in Inner Asian Mountain Corridor
Authors: Endo Eiko , Shoda Shinya , Frachetti Michael , Kaliyeva Zhanargul , Kiyasbek Galymzhan , Zhuniskhanov Aidyn , Liu Xinyi , Dupuy Paula Doumani
Published: June 2023

The Inner Asian Mountain Corridor (IAMC) has been identified as a major pathway for the westward dispersal of millet from Northern China, where it was initially cultivated. Cross-disciplinary investigations are necessary to distinguish cultivated millet taxa from their wild relatives and to clarify the social context underlying millet adoption in novel environments. Despite the ambiguity in distinguishing Setaria italica from Panicum miliaceum or other Setaria species using conventional analysis of charred macro remains, recent attention has focused on the time gap between the introduction of S. italica to IAMC following P. miliaceum. Here, we employed a pottery impression casting method on materials from four Bronze Age sites in eastern/southeastern Kazakhstan to investigate the surface textures of grain impressions on the surface of pottery containers. We successfully identified both millets (Setaeria and Panicum) from three of the sites, Begash, Tasbas, and Dali in the IAMC. Based on our findings, two species of millet were introduced to the region within a much shorter range of time than previously estimated. In addition, the current evidence supports the premise that these cereals were likely utilized for human consumption.
The Development of Feeding Competence in Rehabilitant Orphaned Orangutans and How to Measure It
Authors: Preuschoft Signe , Marshall Andrew J. , Scott Lorna , Badriyah Siti Nur , Purba Melki Deus T. , Yuliani Erma , Corbi Paloma , Yassir Ishak , Wibawanto M. Ari , Kalcher-Sommersguter Elfriede
Published: June 2023

For critically endangered species, restorative conservation becomes increasingly important. Successful re-introduction of rescued wild orangutan orphans requires rehabilitation mimicking maternal rearing in the wild. Feeding competence—what to eat, where and when to find food—needs to be learned before re-introduction. We observed seven orphans (2–10 years old) for a period of 3 years during their rehabilitation at the Yayasan Jejak Pulang forest school. Of the 111 plant genera eaten by the orphans, 92 percent were known orangutan food plants. Five plant genera were eaten by all orphans in over 90 percent of the months within the observation period. The Fruit Availability Index (FAI) was used to predict which parts of a plant were consumed by the orphans. We found that the orphans ate primarily fruit when the FAI was high, but consumed more young leaves, cambium, and pith when FAI was low. Thus, the orphans exhibited food choices very similar to mature wild orangutans and appropriate to forest productivity. The orphans’ acquisition of feeding competence was facilitated by their immersion into a natural forest environment in combination with possibilities for observational learning from conspecifics as well as caregivers modelling food processing and consumption.
Rodents Inhabiting the Southeastern Mu Us Desert May Not Have Experienced Prolonged Heat Stress in Summer 2022
Authors: Guo Yang-Yang , Wang Shan-Shan , Wang Xinyue , Liu Wei , Xu Deli
Published: June 2023

Climate change combined with human activities has altered the spatial and temporal patterns of summer extreme heat in the Mu Us Desert. To determine how those rodents living in the desert respond to increased extreme heat in summer, in July 2022, during the hottest month, we examined the rodent species, vegetation coverage, and small-scale heterogeneity in ambient temperature in the southeastern Mu Us Desert. The results showed that Meriones meridianus, Meriones unguiculatus, and Cricetulus longicaudatus were found in the study area, where the vegetation coverage is 33.5–40.8%. Moreover, the maximum temperature of the desert surface was 61.8 °C. The maximum air temperature at 5 cm above the desert surface was 41.3 °C. The maximum temperature in the burrow at a depth of 15 cm was 31 °C. M. unguiculatus might experience 4–9.3 h of heat stress in a day when exposed outside the burrow, whereas M. meridianus would experience 8.5–10.8 h of heat stress. Yet, inside the burrow, both species were barely exposed to heat stress. In conclusion, adjustments in behavioral patterns can be the main way that rodents in the Mu Us Desert adapt to the extreme heat in the summer.
Special Issue on Performance Analysis in Sport and Exercise
Authors: Annino Giuseppe , Bonaiuto Vincenzo
Published: June 2023

The analysis of human performance has always aroused great interest from s sport scientists and, more recently, the clinical field [...]
Key Technology of TBM Excavation in Soft and Broken Surrounding Rock
Authors: Zhao Hailei , Quan Yongwei , Zhou Jianjun , Wang Liming , Yang Zhenxing
Published: June 2023

Tunnel Boring Machine (TBM), as the most advanced construction equipment for rock tunnels, has been widely used in railway tunnel engineering, water conservancy tunnel engineering, urban rail engineering, coal mine roadway engineering, and other fields. However, the disadvantage of TBM lies in its poor adaptability to complex geological conditions, resulting in a significant reduction in tunneling efficiency and even major accidents due to improper TBM construction measures, especially in weak and fractured strata, which pose a great challenge to TBM construction. Therefore, it is necessary to study the key technologies of TBM construction in weak and fractured strata in order to improve the efficiency of TBM construction. Based on the background of the TBM construction of the Gaoligongshan Tunnel on the Southwest Darui Railway, this paper provides a reference for safe and efficient TBM excavation in weak and fractured areas through research on equipment, excavation parameter control, and construction measures.
An Analysis of Underused Urban Infrastructures: Usage Opportunities and Implementation Barriers for Sustainable Logistics
Authors: Schachenhofer Larissa , Kummer Yvonne , Hirsch Patrick
Published: June 2023

Motivated by the urgent need to discover innovative and sustainable approaches to address the strain on urban resources, this paper introduces a novel concept proposing the utilization of “sleeping assets”. These sleeping assets encompass three distinct categories of urban infrastructures: neglected routes, idle real estate, and underused resources. By harnessing these assets, cities can alleviate the intense competition for land, traffic infrastructure, and parking areas. The findings presented in this paper are derived from an extensive literature study and expert interviews conducted with relevant stakeholders from Hamburg, Paris, Stockholm, and Vienna. Building upon the most pertinent insights from the literature and a structured content analysis of the interviews, we outline the advantages of employing sleeping assets for urban logistics initiatives. Additionally, we identify seven main categories of implementation barriers that must be taken into account. The results of this study reveal political and legislative barriers as one of the major impeding factors in initiating the utilization of sleeping assets. To address these barriers, this paper points towards crucial leverage for cities and provides an outlook on possible forms of sustainable urban logistics implementation. Thus, this work can support researchers as well as practitioners from city administrations and urban logistics interested in using sleeping assets by encouraging the exploitation of unused potential and avoiding particular implementation pitfalls.
A Harmonic and Interharmonic Detection Method for Power Systems Based on Enhanced SVD and the Prony Algorithm
Authors: Gong Junsong , Liu Sanjun
Published: June 2023

To address the problem of harmonic pollution in power systems, a harmonic and interharmonic detection method based on the adaptive order and the dominant factor algorithms is proposed. The proposed method greatly improves the accuracy and precision of harmonic detection, overcoming the notorious problem of high sensitivity to noise of the traditional Prony algorithm that often leads to unsatisfactory detection results. In the proposed method, the “adaptive order determination” algorithm is first used to determine the optimal order of Singular Value Decomposition (SVD) denoising, resulting in a more accurate distinction between signal and noise components. Then, signal reconstruction is carried out to effectively remove noise components to enhance the denoising ability of SVD. This mitigates the Prony algorithm’s high sensitivity to noise and greatly reduces the amplitude of false components in the fitting results. Finally, the dominant factor algorithm is applied to accurately screen out the non-false components in Prony’s fitting results. Simulation results show that the proposed method can effectively reduce signal noise in different noise environments with noise intensities ranging from 5 dB to 30 dB, achieving an average signal-to-noise ratio improvement of around 20 dB. Meanwhile, the identification and screening results of harmonic and interharmonic components in the signal are accurate and reliable, with detection errors in amplitude, frequency, and phase at around 0.5%, 0.01%, and 0.5%, respectively. Overall, the proposed method is well suited for detecting harmonics and interharmonics in power systems under various noise environments.
In Vitro Antiprotozoal Activity of Hibiscus sabdariffa Extract against a Ciliate Causing High Mortalities in Turbot Aquaculture
Authors: Carvalho Ana , Domingues Inês , Carvalho Carla , Silva Artur M. S. , Soares Amadeu M. V. M. , Marques Catarina R.
Published: June 2023

Philasterides dicentrarchi is an histophagous parasite that infects flatfish, namely turbot (Scophthalmus maximus), and cause significant losses in aquaculture units. The available measures for P. dicentrarchi control have limited efficiency, and some cause harm to fish. Hence, sustainable and natural control strategies are urgently needed. This study evaluated the in vitro bioactivity of the ethanol extract of Hibiscus sabdariffa calyces on P. dicentrarchi population growth rate (PGR), oxidative stress biomarkers (glutathione-S-transferases (GST), glutathione reductase (GR), glutathione peroxidase (GPx), total glutathione (TG) and catalase (CAT), neurotoxicity (acetylcholinesterase, AChE), activity and gene expression of proteases as major virulence factors. H. sabdariffa extract inhibited parasite PGR (IC50 = 1.57 mg mL−1), and caused significant changes in the activity of antioxidant enzymes (LOEC = 0.22 mg mL−1), especially GPx, TG, and CAT. The activity of proteases was also severely inhibited (IC50 = 0.76 mg mL−1), and gene expression of catepsin 90 and leishmanolysin proteases was downregulated. Organic acids and phenolic phytochemicals in hibiscus extract are potentially responsible for the antiprotozoal bioactivity herein determined. Therefore, H. sabdariffa extract can be a promising disease-control alternative against the ciliate proliferation, cellular defense mechanisms and pathogenicity. Still, its applicability in aquaculture settings, and potential effects on farmed fish, should be further elucidated.
Biocompatible Phosphorescent O2 Sensors Based on Ir(III) Complexes for In Vivo Hypoxia Imaging
Authors: Samandarsangari Mozhgan , Kozina Daria O. , Sokolov Victor V. , Komarova Anastasia D. , Shirmanova Marina V. , Kritchenkov Ilya S. , Tunik Sergey P.
Published: June 2023

In this work, we obtained three new phosphorescent iridium complexes (Ir1–Ir3) of general stoichiometry [Ir(N^C)2(N^N)]Cl decorated with oligo(ethylene glycol) fragments to make them water-soluble and biocompatible, as well as to protect them from aggregation with biomolecules such as albumin. The major photophysical characteristics of these phosphorescent complexes are determined by the nature of two cyclometallating ligands (N^C) based on 2-pyridine-benzothiophene, since quantum chemical calculations revealed that the electronic transitions responsible for the excitation and emission are localized mainly at these fragments. However, the use of various diimine ligands (N^N) proved to affect the quantum yield of phosphorescence and allowed for changing the complexes’ sensitivity to oxygen, due to the variations in the steric accessibility of the chromophore center for O2 molecules. It was also found that the N^N ligands made it possible to tune the biocompatibility of the resulting compounds. The wavelengths of the Ir1–Ir3 emission maxima fell in the range of 630–650 nm, the quantum yields reached 17% (Ir1) in a deaerated solution, and sensitivity to molecular oxygen, estimated as the ratio of emission lifetime in deaerated and aerated water solutions, displayed the highest value, 8.2, for Ir1. The obtained complexes featured low toxicity, good water solubility and the absence of a significant effect of biological environment components on the parameters of their emission. Of the studied compounds, Ir1 and Ir2 were chosen for in vitro and in vivo biological experiments to estimate oxygen concentration in cell lines and tumors. These sensors have demonstrated their effectiveness for mapping the distribution of oxygen and for monitoring hypoxia in the biological objects studied.
A Metasurface Plasmonic Analysis Platform Combined with Gold Nanoparticles for Ultrasensitive Quantitative Detection of Small Molecules
Authors: Zhou Taohong , Ji Weihao , Fan Hongli , Zhang Li , Wan Xugang , Fan Zhiyong , Liu Gang Logan , Peng Qingzhi , Huang Liping
Published: June 2023

Food safety related to drug residues in food has become a widespread public concern. Small-molecule drug residue analysis often relies on mass spectrometry, thin-layer chromatography, or enzyme-linked immunosorbent assays (ELISA). Some of these techniques have limited sensitivity and accuracy, while others are time-consuming, costly, and rely on specialized equipment that requires skilled operation. Therefore, the development of a sensitive, fast, and easy-to-operate biosensor could provide an accessible alternative to conventional small-molecule analysis. Here, we developed a nanocup array-enhanced metasurface plasmon resonance (MetaSPR) chip coupled with gold nanoparticles (AuNPs) (MSPRAN) to detect small molecules. As sulfamethazine drug residues in poultry eggs may cause health issues, we selected this as a model to evaluate the feasibility of using MSPRAN for small-molecule detection. The MSPRAN biosensor employed competitive immunoassay technology for sulfamethazine detection. The limit of detection was calculated as 73 pg/mL, with sensitivity approximately twice that of previously reported detection methods. Additionally, the recovery rate of the biosensor, tested in egg samples, was similar to that measured using ELISA. Overall, this newly developed MSPRAN biosensor platform for small-molecule detection provides fast and reliable results, facile operation, and is relatively cost-effective for application in food safety testing, environmental monitoring, or clinical diagnostics.
The Role of Negative Perfectionism and the Relationship between Critical Thinking and the Halo Effect: Insights from Corporate Managers in Human Resources
Authors: Lv Jiayi , Sun Zhaoyang , Li Hao , Hou Yubo
Published: June 2023

This research aims to explore the relationship between critical thinking and the halo effect among managers working in the Human Resources (HR) departments of corporations. By utilizing a sample of over 301 corporate HR managers as participants, this study provides valuable insight into the dynamics between critical thinking, the halo effect, and the mediating role of negative perfectionism. The findings of this study suggest a significant negative relationship between critical thinking and the halo effect, as well as a significant positive relationship between negative perfectionism and the halo effect. Notably, negative perfectionism acts as a mediator between critical thinking and the halo effect. Our research also reveals that compensation level moderates this relationship, with lower-income HR managers exhibiting a stronger association between negative perfectionism and the halo effect compared to higher-income HR managers. These findings significantly contribute to our understanding of the interplay between critical thinking and the halo effect among HR managers in corporate settings. Identifying negative perfectionism as a mediating factor clarifies the underlying mechanisms between critical thinking and the halo effect, while the moderating effect of compensation level highlights the importance of considering contextual factors. The practical implications of this research include the significance of promoting critical thinking skills among HR managers to mitigate the halo effect in job recruitment and performance evaluation. Additionally, organizations should prioritize fairness and consistency in compensation levels to minimize the influence of negative perfectionism and its impact on the halo effect.
Performance of Novel U-Connector in CFS Truss-to-Column Bolted Connection under Axial Force
Authors: Lukačević Lazar , Krolo Paulina , Bakran Antonio , Palijan Ivan
Published: June 2023

This paper presents an experimental and numerical investigation of the tensile and compressive behaviour of a novel U-connector in the cold-formed steel (CFS) truss-to-column connection. Tensile tests were performed on 12 specimens representing the tension chords of the trusses in the connection. The results were used to validate a finite element model. The validated model was then subjected to both compressive and tensile loads, which revealed low stiffness in both the compressive and tensile components of the proposed connection. An optimisation of the geometry by using one long nut instead of two nuts was carried out to improve the behaviour and stiffness of the connection. The optimised results were compared with both experimental and numerical data, and conclusions were drawn regarding the effectiveness of the components in the proposed connection. The use of long-nut optimisation in the tension and compression components of the proposed connection shows a significant increase in load-bearing capacity, which makes it very promising for future applications in CFS truss-to-column connections. However, further validation through experimental testing is required to confirm the effectiveness and reliability of the connection in full-scale structures.
Composite Characteristic and Mechanism Analysis of Human Settlements in Jinan City Based on Demand Hierarchy Theory
Authors: Gao Jiaji , Cao Fucun , Sun Dongqi , Bai Zhizhen , Lang Zhihan
Published: June 2023

The composition of human settlements is important to resolving urban issues, such as land shortage, and to rationally distributing human settlements and social resources. Based on the demand hierarchy theory, this paper comprehensively used the methods of location entropy, information entropy, and geographic detector to analyze the characteristics and driving mechanism of the specialization, composition, and compatibility of human settlements at all levels. (1) The composite characteristics of human settlements were influential; that is, clear concentration differences were found among various types of human settlements, with the specialization of primary human settlements having the highest concentration. The specialization of human settlements was characterized as center–periphery; that is, the centrality of basic and high-level human settlements was obvious and the discreteness of primary human settlements was obvious. (2) The spatial differences in the north–central–south compositions of human settlements were also influential. These spatial differences showed that the composite characteristics of the basic high-level and intermediate high-level human settlements were similar, and the composite features were weakly affected by the scale of the elements. (3) Furthermore, single human settlements were dominant, and the multi-level human settlements that were compatible with the comprehensive composite form were the primary form of expression. The interactions between the primary and other human settlements were relatively high. Finally, (4) the high-level human settlement elements and regional economic vitality were the dominant factors of the composite characteristic heterogeneity of human settlements. Residential self and social attributes have an impact on the diversity of their needs, and they interact with human settlements through human settlement elements. The results of the study are of great significance to the rational allocation of human settlements and the promotion of the composition of human settlements.
Management of Cutaneous Head and Neck Squamous and Basal Cell Carcinomas for Immunocompromised Patients
Authors: Bommakanti Krishna K. , Kosaraju Nikitha , Tam Kenric , Chai-Ho Wanxing , St. John Maie
Published: June 2023

The incidence of non-melanoma skin cancer (NMSC) continues to rise, and more than one million cases are diagnosed in the United States each year. The increase in prevalence has been attributed to increased lifespan and improvements in survival for conditions that increase the risk of these malignancies. Patients who are immunocompromised have a higher risk of developing NMSC compared to the general population. In immunosuppressed patients, a combination of prevention, frequent surveillance, and early intervention are necessary to reduce morbidity and mortality. In this review, we collate and summarize current knowledge regarding pathogenesis of head and neck cutaneous SCC and BCC within immunocompromised patients, examine the potential role of the immune response in disease progression, and detail the role of novel immunotherapies in this subset of patients.
A Cu-SiO2 Catalyst for Highly Efficient Hydrogenation of Methyl Formate to Methanol
Authors: Wu Jincheng , Liu Guoguo , Liu Qin , Zhang Yajing , Ding Fu , Wang Kangjun
Published: June 2023

The hydrogenation of methyl formate to methanol is considered one of the most effective methods for recycling methyl formate products. We recently developed a highly efficient and cost-effective Cu-SiO2 catalyst using the ammonia-evaporation (AE) method. The Cu-SiO2-AE catalyst demonstrated superior performance, achieving a methyl formate conversion of 94.2% and a methanol selectivity of 99.9% in the liquid product. The catalyst also displayed excellent stability over a durability test of 250 h. Compared to the commonly used Cu-Cr catalyst in the industry, the Cu-SiO2-AE catalyst exhibited higher conversion of methyl formate and methanol yield under the same reaction conditions. Characterization results revealed a significant presence of Si-OH groups in the Cu-SiO2-AE catalyst. These groups enhanced the hydrogen spillover effect and improved hydrogenation efficiency by preventing sintering during the reaction to stabilize the Cu species. The strategy employed in this study is applicable to the rational design of highly efficient catalysts for industrial applications.
Efficacy and Safety of Biological Therapies and JAK Inhibitors in Older Patients with Inflammatory Bowel Disease
Authors: Fries Walter , Basile Giorgio , Bellone Federica , Costantino Giuseppe , Viola Anna
Published: June 2023

With the introduction of more and more monoclonal antibodies selectively targeting various mediators of the immune system, together with Janus-Kinase (JAK)-inhibitors with variable affinities towards different JAK subtypes, the available therapeutic options for the treatment of inflammatory bowel diseases (IBD) have undergone an acceleration in the last five years. On the other hand, the prevalence of IBD patients over 65-years-old is steadily increasing, and, with this, there is a large population of patients that presents more comorbidities, polypharmacy, and, more frequently, frailty compared to younger patients, exposing them to potentially major risks for adverse events deriving from newer therapies, e.g., infections, cardiovascular risks, and malignancies. Unfortunately, pivotal trials for the commercialization of new therapies rarely include older IBD patients, and those with serious comorbidities are virtually excluded. In the present review, we focus on existing literature from pivotal trials and real-world studies, analyzing data on efficacy/effectiveness and safety of newer therapies in older IBD patients with special emphasis on comorbidities and frailty, two distinct but intercorrelated aspects of the older population since age by itself seems to be of minor importance.
Stability Analysis of Hydrodynamic Mechanical Seals in Multifrequency Excitation
Authors: Sun Dianfeng , Sun Jianjun , Liu Fei , Xu Xiaohua , Zhang Dongliang
Published: June 2023

The dynamic characteristics of the complex relationship among the sealing system, excitation, and response have a considerable impact on the operational reliability of hydrodynamic mechanical seals, which is a critical issue in the field of sealing theory and technology. Scholars at home and abroad have established dynamic models and calculated the displacement responses of dynamic and static rings in the time domain based on the force on these rings so that the response results can be used for system stability analysis. Neither are the excitation characteristics of cavitation load extracted, nor are the distance response and system leakage rate of the dynamic and static rings analyzed under coupled cavitation and random excitation. In this study, under different operating conditions of the hydrodynamic mechanical seal system, the liquid film evaporation load and seismic load are applied to study the frequency domain response of the distance between the dynamic and static rings and the system leakage rate. The following conclusions have been obtained: Assuming that the chamber pressure is 0.5 MPa and the spring specific pressure is 0.055 MPa, during stable operation, the distance between the moving and stationary rings at 1500 rpm~3000 rpm speeds is 1.12 μm~3.05 μm. For a specific spring pressure of 0.055 MPa, medium pressures of 0.2 MPa~1.0 MPa, and spindle speeds of 1500 rpm~3000 rpm, the excitation force is 30 N, and the frequency is 30 Hz, And the seismic load is assumed to be sinusoidal, the excitation force is 6 N, the fundamental frequency is 120 Hz, and the system leak rate is in 0.1 mL/min~1.3 mL/min. Under multi-frequency excitation coupling, the distance between the dynamic and static rings will decrease as the pressure of the medium in the sealing cavity increases, and this will increase with the increase in the rotating speed. The leakage rate of the system will increase with the increase in the rotating speed and the pressure of the medium, and the test value is largely consistent with the theoretical value.
Chemotherapy Regimens for Non-Metastatic Conventional Appendicular Osteosarcoma: A Literature Review Based on the Outcomes
Authors: Soares do Brito Joaquim , Santos Rodrigo , Sarmento Marco , Fernandes Pedro , Portela José
Published: June 2023

Osteosarcoma is a rare condition with a complex treatment. Most protocols include neoadjuvant chemotherapy, surgery, and consolidation chemotherapy as the standard of treatment. However, the use of neoadjuvant chemotherapy lacks scientific evidence proving superiority in opposition to the use of isolated chemotherapy in an adjuvant regimen after surgery. We conducted a review for studies published in English between 1980 and 2020, using the MEDLINE/PubMed and Scopus electronic databases, to evaluate the outcomes when using neoadjuvant chemotherapy or adjuvant chemotherapy strategies in the treatment of non-metastatic appendicular osteosarcoma, as well as the toxicity associated with different chemotherapeutic regimens. Patients were divided into a neoadjuvant chemotherapy group (NAC) and adjuvant chemotherapy group (ACT), depending on the chemotherapy regimen used in association with surgery. A total of 1254 articles in English were screened by title and abstract, and 146 were pre-selected for full reading and analysis. A total of 24 assays matching the inclusion criteria were selected: 10 prospective and 14 retrospective studies. This review points to an absence of significative differences in outcomes, namely overall survival, disease-free survival/event-free survival rates, or toxicity, regarding neoadjuvant or single adjuvant chemotherapy strategies used in the treatment of appendicular non-metastatic osteosarcomas. However, there is a significative difference in population dimensions between the NAC and the ACT groups. Additionally, clinical presentation, tumor localization, tumor volume, or histological type were not considered, with these variables presenting the potential to influence these results. Despite these limitations, our findings should allow a re-thinking of our current practice and promote new opportunities to optimize treatment, always looking towards better survival and lower complications rates.
EUS-Guided Diagnosis of Gastric Subepithelial Lesions, What Is New?
Authors: Vasilakis Thomas , Ziogas Dimitrios , Tziatzios Georgios , Gkolfakis Paraskevas , Koukoulioti Eleni , Kapizioni Christina , Triantafyllou Konstantinos , Facciorusso Antonio , Papanikolaou Ioannis S.
Published: June 2023

Gastric subepithelial lesions (SELs) are intramural lesions that arise underneath the gastric mucosa. SELs can be benign, but can also be malignant or have malignant potential. Therefore, correct diagnosis is crucial. Endosonography has been established as the diagnostic gold standard. Although the identification of some of these lesions can be carried out immediately, solely based on their echo characteristics, for certain lesions histological examination is necessary. Sometimes histology can be inconclusive, especially for smaller lesions. Therefore, new methods have been developed in recent years to assist decision making, such as contrast enhanced endosonography, EUS elastography, and artificial intelligence systems. In this narrative review we provide a complete overview of the gastric SELs and summarize the new data of the last ten years concerning the diagnostic advances of endosonography on this topic.
MRI-Cavernosography: A New Diagnostic Tool for Erectile Dysfunction Due to Venous Leakage: A Diagnostic Chance
Authors: Di Serafino Marco , Pucci Luigi , Iacobellis Francesca , Fasbender Jacobitti Marco , Ronza Roberto , Sabatino Vittorio , De Luca Luigi , Iossa Vincenzo , Langella Nunzio Alberto , Persico Francesco , Grimaldi Dario , Schillirò Maria Laura , Lessoni Luca , Notorio Maurizio , Carrino Maurizio , Romano Luigia
Published: June 2023

Erectile dysfunction caused by venous leakage is a vascular disease in which blood fails to accumulate in the corpora cavernosa due to the abrupt drainage of blood from the penis secondary to an abnormal venous network that affects 1 to 2% of men under 25 years old and about 10 to 20% over 60 years old, who do not raise a sufficient erection for penetrative sex. The study of the venous leak and its characterization in young patients with erectile dysfunction represent a diagnostic challenge, and imaging remains the best way to diagnose this condition. In the article, it is described the methods of execution and the diagnostic role of the cavernous MRI in the study of vasogenic erectile dysfunction from the venous leak, proposing it as a good alternative to the cavernous CT, considering the satisfactory results in terms of diagnostic interpretation, the absence of ionizing radiation, the higher soft tissue resolution of the imaging method and the lower administration of contrast agent.
Diagnosis and Treatment of Adenomyosis with Office Hysteroscopy—A Narrative Review of Literature
Authors: Gkrozou Fani , Vatopoulou Anastasia , Skentou Chara , Paschopoulos Minas
Published: June 2023

Introduction: Adenomyosis is a common chronic disease in women of reproductive age, characterised by the presence of ectopic endometrial tissue within myometrium. Even though adenomyosis presents with chronic pelvic pain, menorrhagia or abnormal uterine bleeding, dysmenorrhoea, and dyspareunia and is often recognised after hysterectomies. However, the development of ultrasonography and magnetic resonance imaging has improved the pre-operative diagnosis of the disease. Hysteroscopy provides information in real time from the uterine cavity and the offers the possibility of obtaining direct biopsies. Material and Methods: The literature was searched via Pubmed and Embase with the following headings: diagnosis of adenomyosis or adenomyoma and office hysteroscopy, hysteroscopy findings of adenomyosis or adenomyoma, treatment of adenomyosis or adenomyoma with office hysteroscopy. Results: The literature showed that hysteroscopy can identify superficial adenomyosis. There are a variety of hysteroscopic images that can be connected with the disease. New equipment like the spirotome has been used to access deeper layers of myometrium and obtain biopsies under direct vision from the adenomyotic areas. Different methods of treatment have been also described, like enucleation of focal superficial adenomyoma, coagulation, evacuation of cystic adenomyosis when the lesion is smaller than 1.5 cm, and resection of adenomyotic nodules in case of bigger lesions (>1.5 cm). Diffuse superficial adenomyosis is also managed by resection. Conclusions: Hysteroscopy has revolutionised the approach to adenomyosis. It is a useful tool in assessing mainly superficial adenomyosis. The role of hysteroscopy in surgical management of adenomyosis need to be confirmed with further studies.
Methodological Approach to Assessment Socio-Economic Development of the Chuvash Republic (Subject of the Russian Federation)
Authors: Ladykova Tatyana , Ivanova Tatyana , Streltsov Viktor , Sayganov Anatoly , Ladykova Ekaterina
Published: June 2023

The article develops a methodological approach to the assessment of socio-economic development of the Chuvash Republic, which allows to consider the factors with heterogeneous metrics. The scientific novelty of the study lies in the combination of methods used and the sequence of stages implemented: (1) index analysis of thirty-two indicators divided into seven macro-regional blocks (income, labor, business, ecology, social, prospects, finance); (2) development of formulas for each of them and calculation of integral indicators characterizing their dynamics; (3) development of a formula to determine the rate of socio-economic development; (4) one hundred graphs for forecasting socio-economic development were constructed; (5) thirty-one legal and regulatory acts were analyzed and the dependence by year between the indicator of the rate of socio-economic development developed by the authors and the number of legal and regulatory acts implemented in the country and the region was revealed; (6) a refined classification of the rate of socio-economic development was proposed. Having determined the current situation (2020 is a state close to sustainable—the rate of 99.5%, respectively), and based on the calculated forecast values of the rate of socio-economic development of the Chuvash Republic, it is possible to influence this process depending on the objectives for the medium term, taking the necessary regulatory legal acts, aimed at financing specific macroeconomic blocks. This methodical approach is a universal calculation tool and has great potential for further research. It can be used to assess not only the impact of certain indicators on socio-economic development, it is also applicable to other sectors and spheres of activity.
Constructing a Novel E-Learning Course, Educational Computational Chemistry through Instructional Design Approach in the TPASK Framework
Authors: Hernández-Ramos José , Rodríguez-Becerra Jorge , Cáceres-Jensen Lizethly , Aksela Maija
Published: June 2023

The educational scenario after the COVID-19 confinement presents new challenges for teachers. Technological advances require teachers to be prepared for instruction through technology, and with this, the need for e-learning courses arose to strengthen this knowledge. This article aims to describe an innovative e-learning course in Educational Computational Chemistry (ECC) for in-service chemistry teachers through an Instructional Design (ID) that allows the development of the constructs associated with the Technological Pedagogical Science Knowledge (TPASK) framework. From the literature overview, relevant findings were raised concerning ID and its potential technological support. The results indicate that an effective ID must present general elements, such as the organisation and generation of content, progress monitoring, and feedback instances. However, the stages of engagement, flexibility, and positioning are relevant elements. These design elements are linked to emerging technological tools, such as artificial intelligence for generating audiovisual material, interactive content development, and event logs. In addition, positive results are evident from the teachers who participated in the ECC e-learning course, who project the knowledge, computer skills, and learning acquired into their professional work as chemistry teachers. Based on the above, a course design for ECC is proposed with general guidelines that contribute to the continuous training of in-service chemistry teachers.
A FL-Based Radio Map Reconstruction Approach for UAV-Aided Wireless Networks
Authors: Tan Zhiqiang , Xiao Limin , Tang Xinyi , Zhao Ming , Li Yunzhou
Published: June 2023

Radio maps, which can provide metrics for signal strength at any location in a geographic space, are useful for many applications of 6G technologies, including UAV-assisted communication, network planning, and resource allocation. However, current crowd-sourced reconstruction methods necessitate large amounts of privacy-sensitive user data and entail the training of all data with large models, especially in deep learning. This poses a threat to user privacy, reducing the willingness to provide data, and consuming significant server resources, rendering the reconstruction of radio maps on resource-constrained UAVs challenging. To address these limitations, a self-supervised federated learning model called RadioSRCNet is proposed. The model utilizes a super-resolution (SR)-based network and feedback training strategy to predict the pathloss for continuous positioning. In our proposition, users retain the original data locally for training, acting as clients, while the UAV functions as a server to aggregate non-sensitive data for radio map reconstruction in a federated learning (FL) manner. We have employed a feedback training strategy to accelerate convergence and alleviate training difficulty. In addition, we have introduced an arbitrary position prediction (APP) module to decrease resource consumption in clients. This innovative module struck a balance between spatial resolution and computational complexity. Our experimental results highlight the superiority of our proposed framework, as our model achieves higher accuracy while incurring less communication overheads in a computationally and storage-efficient manner as compared to other deep learning methods.