bluuebunny/crossref_metadata_2025 huggingface dataset:
cGAS-activated endothelial cell–T cell cross-talk initiates tertiary lymphoid structure formation
Authors: Zhao Ruibo , Zhang Jinghe , Ma Jialu , Qu Yali , Yang Zhenrong , Yin Zhinan , Li Fengyin , Dong Zhongjun , Sun Qinmiao , Zhu Shu , Chen Zhijian J. , Gao Daxing
Published: August 2024

Aberrant activation of the cyclic guanosine monophosphate–adenosine monophosphate synthase–stimulator of interferon genes (cGAS-STING) pathway causes autoimmunity in humans and mice; however, the exact mechanism by which the cGAS-STING pathway initiates adaptive immunity and tissue pathology is still not fully understood. Here, we used a cGAS knockin (KI) mouse model that develops systemic autoimmunity. In the lungs of cGAS-KI mice, blood vessels were enclosed by organized lymphoid tissues that resemble tertiary lymphoid structures (TLSs). Cell-intrinsic cGAS induction promoted up-regulation of CCR5 in CD8
+
T cells and led to CCL5 production in vascular endothelial cells. Peripheral CD8
+
T cells were recruited to the lungs and produced CXCL13 and interferon-γ. The latter triggered endothelial cell death, potentiated CCL5 production, and was essential for TLS establishment. Blocking CCL5 or CCR5, or depleting CD8
+
T cells, impaired TLS formation. cGAS-mediated TLS formation also enhanced humoral and antitumor responses. These data demonstrate that cGAS signaling drives a specialized lymphoid structure that underlies autoimmune tissue pathology.
Examination of static fission properties of $$^{236}$$U and $$^{233}$$Th using Cassinian oval parametrization within the macroscopic–microscopic approach
Authors: Jachimowicz P. , Capote R. , Kowal M.
Published: August 2024

We have conducted a thorough analysis of the potential energy surfaces (PES) in $$^{236}$$

236

U and $$^{233}$$

233

Th using the Cassini-ovals parameterization within the macro–micro approach. We employed the state-of-the-art immersion water flow (IWF) method to study the saddles on four-dimensional energy grids encompassing reflection-asymmetric shapes. For $$^{233}$$

233

Th, we computed the adiabatic potential energy surfaces by minimizing configurations with one blocked neutron within ten levels below and above the Fermi level. Our results show satisfactory agreement with empirical and experimental estimates for both nuclei, specifically regarding the first and second fission barriers. This suggests that our method holds promise in efficiently describing non-compact shapes while reducing the dimensionality of the space without sacrificing accuracy. Interestingly, employing Cassinian oval parameterization fails to reveal a pronounced, hyper-deformed third minimum in the potential energy landscape. Instead, only a shallow third minimum is observed for $$^{233}$$

233

Th, while in $$^{236}$$

236

U, this minimum ultimately vanishes. This finding holds significant importance when considering the modeling of fission cross-sections.
Conversions Between Six Models of Finite Automata
Authors: Hospodár Michal , Jirásková Galina
Published: August 2024

We examine the costs of the conversions between six automata models: deterministic finite automata, partial deterministic finite automata, nondeterministic finite automata with a unique final state and multiple final states, respectively, alternating finite automata, and Boolean finite automata. We present a tight upper bound for each conversion. All witnesses are described over a unary or binary alphabet, and we show that whenever a binary alphabet is used, it is always optimal.
Modeling Individual Fairness Beliefs and Its Applications
Authors: Zhang Chenglong , Jacob Varghese S. , Ryu Young U.
Published: August 2024

One of the criticisms made about data and algorithm-driven intelligent systems is that their results are viewed as being unfair or inequitable by individuals who believe in fairness criteria other than those embedded in the system design. In fact, computer and data scientists admit potential unfairness residing in intelligent systems. Accordingly, various approaches have been proposed to make intelligent systems fair. However, the consideration of a fundamental issue is missing in current efforts to design fair intelligent systems:
Fairness is in the eye of the beholder
. That is, the concept of fairness is very often highly subjective in most domains. Based on the premise that fairness is subjective, we propose a framework to represent and quantify individuals’ subjective fairness beliefs and provide methodologies to aggregate them. The proposed approach provides insight into how a population will assess the fairness of a decision or policy, which in turn can provide guidance for policy as well as designing intelligent systems.
Contribution of the Arterial Cells to Atherosclerosis and Plaque Formation
Authors: Naiya Tushar , Meganathan Ilamaran , Ness Nathan , Oudit Gavin Y. , Murray Allan , Kassiri Zamaneh
Published: August 2024

Atherosclerosis is commonly known as an inflammatory disease that is characterized by lipid deposition in the arterial wall, causing gradual restriction or complete blockade of blood flow, which can cause complications such as myocardial infarction, stroke, or peripheral artery disease. Several factors contribute to initiation and progression of atherosclerotic plaque formation. The role of macrophages and leukocytes in atherosclerosis have been well explored. Here, we provide an overview of what has been reported on the role and impact of the arterial cells on plaque formation, and vice versa. The atherogenic environment can trigger transformation and dedifferentiation of the endothelial cells, smooth muscle cells, and fibroblasts whereby they can either directly contribute to plaque formation, or influence its composition. Recent studies have demonstrated the plasticity in the identity of the arterial cells, formation of intermediate cell types that share the characteristics of multiple cell types, and have revealed novel roles and functions for these cells in atherosclerosis. The potential for all vascular cells to cross-transdifferentiate, and detection of cells with mosaic characteristics in the atherosclerotic plaques reveal that the plaque environment is a complex and dynamic environment that could regulate the disease progression independent from the circulating lipid levels. We will also provide an overview on the interplay between sex and atherosclerosis, which has remained an underexplored area.
Enriching Wheat Bread With Banana Peel Powder: Impact on Nutritional Attributes, Bioactive Compounds, and Antioxidant Activity
Authors: Akhter Most. Jesmin , Al-Amin Md. , Hossain Md Akram , Kamal Md. Murtuza
Published: August 2024

This research investigated the impact of enriching bread with banana peel powder (BPP) on nutritional attributes, bioactive components, antioxidant activity, and sensory characteristics. Four bread samples were prepared and evaluated: S1 (control), S2 (5% BPP), S3 (7% BPP), and S4 (10% BPP). The addition of BPP resulted in a reduction in moisture content and an increase in ash, fat, protein, and fibre levels, while reducing overall carbohydrate content. Furthermore, BPP‐enriched bread exhibited an increase in total phenolic content (TPC) (ranging from 28.46 to 42.38 mg GAE/100 g) and total flavonoid content (TFC) (ranging from 6.63 to 9.46 QE mg/g), indicating enhanced antioxidant properties. The DPPH assay demonstrated the antioxidant potential of BPP‐incorporated bread, with the radical scavenging activity (RSA) increasing from 18.84% to 53.03% with increasing BPP enrichment. Color assessment revealed changes in both crust and crumb, with a decrease from 78.46 to 40.53 in the lightness (L∗) value of the crust and from 61.21 to 41.10 in the lightness (L∗) value of the crumb. Additionally, changes in a∗ and b∗ values were observed. The a∗ values varied between 17.59 and 12.42 for the crust and between 6.96 and 5.89 for the crumb. The b∗ values varied between 31.61 and 23.65 for the crust and between 19.63 and 16.58 for the crumb. Sensory evaluation suggested that up to 5% BPP inclusion in bread mirrored the texture, taste, appearance, and overall acceptability of control bread, but enrichment beyond 5% resulted in lower sensory scores. In summary, the incorporation of BPP significantly influenced various aspects of bread, highlighting its potential for applications in the food and industry sectors.
Analysis of Mechanical Properties and Damage Behavior of Coal and Sandstone under Different Impact Velocities
Authors: Zhang Guoning , Yu Yongjiang , Zhang Wei
Published: August 2024

The fracture behavior and damage characteristics of coal and rock under dynamic failure are important factors in evaluating their mechanical characteristics. In this study, a split Hopkinson pressure bar (SHPB) was used to carry out dynamic tests on coal and sandstone samples, and the mechanical characteristics and energy evolution of coal and sandstone under different impact velocities were studied. The results show that with an increase in impact velocity, the dynamic compressive strength of coal and sandstone increases in a power function. The dynamic deformation modulus shows different evolution characteristics at different stages, and the average deformation modulus can better reflect the deformation characteristics of coal and sandstone in the loading stage. With the increase in strain rate, the incident energy (WI), reflected energy (WR), and transmitted energy (WT) increase in a quadratic function. The reflected and transmitted energy increases linearly with the increase in incident energy; the reflected energy growth rate of coal samples is higher than that of sandstone; and the transmitted energy growth rate of sandstone is higher than that of coal. The damage variable (Dd) of coal and sandstone shows an S‐shaped trend with loading time. The peak damage degree of sandstone is more sensitive to the strain rate. The relevant results can provide a theoretical basis for coal mine disaster warning and tunnel support.
Engaging People with Dementia in Community Art Activities: The Perspective of Art Collaborators
Authors: Bazooband Azam , Courtney-Pratt Helen , Doherty Kathleen , Tierney Laura
Published: August 2024

Community‐based arts have the potential to offer multiple benefits to people living with dementia; however, the level of uptake of these activities is unclear. This study sought to examine the perspectives of key stakeholders: the presenting artists and those who are responsible for planning art activities within the context of community to examine opportunities for and barriers to participation of people living with dementia in community‐based art activities. Inductive thematic analysis approach of Braun and Clarke (2006) was applied to identify, analyse, and report themes from the semistructured interviews with artists and art planners. Important factors to be taken into account when delivering community‐based art activities inclusive of people living with dementia arose under three major themes: perceptions and knowledge of dementia, the inherently inclusive qualities of arts, and practical approaches to delivery of the activity. Both artists and art planners felt that understanding motivations and expectations, effective communication, access, and support for both themselves and people with dementia were crucial factors to create and deliver dementia inclusive arts in the context of community. Both artists and art planners believed that community‐based art activities can be inclusive of people living with dementia. Changes in design, delivery mode, communication, and access to the activities might empower this group of people to take part in such activities in the community.
Supplementary Table ST-2 from Neem Leaf Glycoprotein Disrupts Exhausted CD8+ T-Cell–Mediated Cancer Stem Cell Aggression
Authors: Chakravarti Mohona , Bera Saurav , Dhar Sukanya , Sarkar Anirban , Choudhury Pritha Roy , Ganguly Nilanjan , Das Juhina , Sultana Jasmine , Guha Aishwarya , Biswas Souradeep , Das Tapasi , Hajra Subhadip , Banerjee Saptak , Baral Rathindranath , Bose Anamika
Published: August 2024

The file contains Supplementary Table ST-2
Supplementary Figure S5 from MYC Family Amplification Dictates Sensitivity to BET Bromodomain Protein Inhibitor Mivebresib (ABBV075) in Small-Cell Lung Cancer
Authors: Plotnik Joshua P. , Zha Zheng , Feng Weiguo , Lee Irene , Riehm Jacob , McClure Ryan A. , Sandoval Stephanie , Uziel Tamar , Murphy Erin , Lu Xin , Lam Lloyd T.
Published: August 2024

Supplementary Figure S5
Supplementary Figure S4 from MYC Family Amplification Dictates Sensitivity to BET Bromodomain Protein Inhibitor Mivebresib (ABBV075) in Small-Cell Lung Cancer
Authors: Plotnik Joshua P. , Zha Zheng , Feng Weiguo , Lee Irene , Riehm Jacob , McClure Ryan A. , Sandoval Stephanie , Uziel Tamar , Murphy Erin , Lu Xin , Lam Lloyd T.
Published: August 2024

Supplementary Figure S4
Figure S4 from DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor
Authors: Tiburcio Patricia D.B. , Desai Kavita , Kim Jiwoong , Zhou Qinbo , Guo Lei , Xiao Xue , Zhou Li , Yuksel Aysen , Catchpoole Daniel R. , Amatruda James F. , Xu Lin , Chen Kenneth S.
Published: August 2024

Supplementary Figure S4. (A) TARGET tumors, by mutational class. (B,C) GSEA of mutational classes matched to transcriptional signatures in TARGET tumors; NES, normalized enrichment score.
Figure S2 from DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor
Authors: Tiburcio Patricia D.B. , Desai Kavita , Kim Jiwoong , Zhou Qinbo , Guo Lei , Xiao Xue , Zhou Li , Yuksel Aysen , Catchpoole Daniel R. , Amatruda James F. , Xu Lin , Chen Kenneth S.
Published: August 2024

Supplementary Figure S2. (A) Mutational burden in Wilms tumors compared to other tumor types in TCGA. (B) Most common SNV types in Wilms tumors analyzed by WES. (C) SNV types in Wilms tumor compared to subtypes of renal cell carcinoma. (D) Variant classes in Wilms tumor compared to subtypes of renal cell carcinoma.
Supplementary Table 2 from Pediatric Chordoma: A Tale of Two Genomes
Authors: O’Halloran Katrina , Hakimjavadi Hesamedin , Bootwalla Moiz , Ostrow Dejerianne , Kerawala Rhea , Cotter Jennifer A. , Yellapantula Venkata , Kaneva Kristiyana , Wadhwani Nitin R. , Treece Amy , Foreman Nicholas K. , Alexandrescu Sanda , Velazquez Vega Jose , Biegel Jaclyn A. , Gai Xiaowu
Published: August 2024

Allele frequency of mtDNA variants in the skull base chordoma cohort across multiple samples. Comparisons are broken down by sample number and by variant class.
Supplementary Data from Pediatric Chordoma: A Tale of Two Genomes
Authors: O’Halloran Katrina , Hakimjavadi Hesamedin , Bootwalla Moiz , Ostrow Dejerianne , Kerawala Rhea , Cotter Jennifer A. , Yellapantula Venkata , Kaneva Kristiyana , Wadhwani Nitin R. , Treece Amy , Foreman Nicholas K. , Alexandrescu Sanda , Velazquez Vega Jose , Biegel Jaclyn A. , Gai Xiaowu
Published: August 2024

Rare mtDNA variants of pediatric chordomas
Supplementary Figure 5 from NSCLC Extracellular Vesicles Containing miR-374a-5p Promote Leptomeningeal Metastasis by Influencing Blood‒Brain Barrier Permeability
Authors: Jin Jie , Cui Yumeng , Niu Huicong , Lin Yanli , Wu Xiaojie , Qi Xuejiao , Bai Kaixuan , Zhang Yu , Wang Youliang , Bu Hui
Published: August 2024

ADD3 and ZO-1 were co-localization.
Supplementary figure 9 from Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer
Authors: Archer Maddison , Begemann Diane , Gonzalez-Kozlova Edgar , Nepali Prerna R. , Labanca Estefania , Shepherd Peter , Dogra Navneet , Navone Nora , Kyprianou Natasha
Published: August 2024

EMT profiling in PDX specimens
Supplementary figure 7 from Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer
Authors: Archer Maddison , Begemann Diane , Gonzalez-Kozlova Edgar , Nepali Prerna R. , Labanca Estefania , Shepherd Peter , Dogra Navneet , Navone Nora , Kyprianou Natasha
Published: August 2024

RNAseq gene signatures
Supplementary figure 4 from Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer
Authors: Archer Maddison , Begemann Diane , Gonzalez-Kozlova Edgar , Nepali Prerna R. , Labanca Estefania , Shepherd Peter , Dogra Navneet , Navone Nora , Kyprianou Natasha
Published: August 2024

RNAseq analysis
Supplementary figure 12 from Kinesin Facilitates Phenotypic Targeting of Therapeutic Resistance in Advanced Prostate Cancer
Authors: Archer Maddison , Begemann Diane , Gonzalez-Kozlova Edgar , Nepali Prerna R. , Labanca Estefania , Shepherd Peter , Dogra Navneet , Navone Nora , Kyprianou Natasha
Published: August 2024

CW069 dose response
Data from Neem Leaf Glycoprotein Disrupts Exhausted CD8+ T-Cell–Mediated Cancer Stem Cell Aggression
Authors: Chakravarti Mohona , Bera Saurav , Dhar Sukanya , Sarkar Anirban , Choudhury Pritha Roy , Ganguly Nilanjan , Das Juhina , Sultana Jasmine , Guha Aishwarya , Biswas Souradeep , Das Tapasi , Hajra Subhadip , Banerjee Saptak , Baral Rathindranath , Bose Anamika
Published: August 2024

Abstract
Targeting exhausted CD8+ T-cell (TEX)–induced aggravated cancer stem cells (CSC) holds immense therapeutic potential. In this regard, immunomodulation via Neem Leaf Glycoprotein (NLGP), a plant-derived glycoprotein immunomodulator is explored. Since former reports have proven immune dependent–tumor restriction of NLGP across multiple tumor models, we hypothesized that NLGP might reprogram and rectify TEX to target CSCs successfully. In this study, we report that NLGP’s therapeutic administration significantly reduced TEX-associated CSC virulence in in vivo B16-F10 melanoma tumor model. A similar trend was observed in in vitro generated TEX and B16-F10/MCF7 coculture setups. NLGP rewired CSCs by downregulating clonogenicity, multidrug resistance phenotypes and PDL1, OCT4, and SOX2 expression. Cell cycle analysis revealed that NLGP educated–TEX efficiently pushed CSCs out of quiescent phase (G0G1) into synthesis phase (S), supported by hyper-phosphorylation of G0G1–S transitory cyclins and Rb proteins. This rendered quiescent CSCs susceptible to S-phase–targeting chemotherapeutic drugs like 5-fluorouracil (5FU). Consequently, combinatorial treatment of NLGP and 5FU brought optimal CSC-targeting efficiency with an increase in apoptotic bodies and proapoptotic BID expression. Notably a strong nephron-protective effect of NLGP was also observed, which prevented 5FU-associated toxicity. Furthermore, Dectin-1–mediated NLGP uptake and subsequent alteration of Notch1 and mTOR axis were deciphered as the involved signaling network. This observation unveiled Dectin-1 as a potent immunotherapeutic drug target to counter T-cell exhaustion. Cumulatively, NLGP immunotherapy alleviated exhausted CD8+ T-cell-induced CSC aggravation.

Implications: Our study recommends that NLGP immunotherapy can be utilized to counter ramifications of T-cell exhaustion and to target therapy elusive aggressive CSCs without evoking toxicity.
Data from DROSHA Regulates Mesenchymal Gene Expression in Wilms Tumor
Authors: Tiburcio Patricia D.B. , Desai Kavita , Kim Jiwoong , Zhou Qinbo , Guo Lei , Xiao Xue , Zhou Li , Yuksel Aysen , Catchpoole Daniel R. , Amatruda James F. , Xu Lin , Chen Kenneth S.
Published: August 2024

Abstract
Wilms tumor, the most common pediatric kidney cancer, resembles embryonic renal progenitors. Currently, there are no ways to therapeutically target Wilms tumor driver mutations, such as in the microRNA processing gene DROSHA. In this study, we used a “multiomics” approach to define the effects of DROSHA mutation in Wilms tumor. We categorized Wilms tumor mutations into four mutational subclasses with unique transcriptional effects: microRNA processing, MYCN activation, chromatin remodeling, and kidney developmental factors. In particular, we find that DROSHA mutations are correlated with de-repressing microRNA target genes that regulate differentiation and proliferation and a self-renewing, mesenchymal state. We model these findings by inhibiting DROSHA expression in a Wilms tumor cell line, which led to upregulation of the cell cycle regulator cyclin D2 (CCND2). Furthermore, we observed that DROSHA mutations in Wilms tumor and DROSHA silencing in vitro were associated with a mesenchymal state with aberrations in redox metabolism. Accordingly, we demonstrate that Wilms tumor cells lacking microRNAs are sensitized to ferroptotic cell death through inhibition of glutathione peroxidase 4, the enzyme that detoxifies lipid peroxides.

Implications: This study reveals genotype–transcriptome relationships in Wilms tumor and points to ferroptosis as a potentially therapeutic vulnerability in one subset of Wilms tumor.
Table S3 from Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells
Authors: Picco Gabriele , Rao Yanhua , Al Saedi Angham , Lee Yang , Vieira Sara F. , Bhosle Shriram , May Kieron , Herranz-Ors Carmen , Walker Samantha J. , Shenje Raynold , Dincer Cansu , Gibson Freddy , Banerjee Ruby , Hewitson Zoe , Werner Thilo , Cottom Joshua E. , Peng Yang , Deng Nanhua , Zhang Youyou , Nartey Eldridge N. , Nickels Leng , Landis Philip , Conticelli Daniela , McCarten Katrina , Bush Jacob , Sharma Mamta , Lightfoot Howard , House David , Milford Emma , Grant Emma K. , Glogowski Michal P. , Wagner Craig D. , Bantscheff Marcus , Rutkowska-Klute Anna , Zappacosta Francesca , Pettinger Jonathan , Barthorpe Syd , Eberl H. Christian , Jones Brian T. , Schneck Jessica L. , Murphy Dennis J. , Voest Emile E. , Taygerly Joshua P. , DeMartino Michael P. , Coelho Matthew A. , Houseley Jonathan , Sharma Geeta , Schwartz Benjamin , Garnett Mathew J.
Published: August 2024

This file contain information on the Cell lines and organoids used in this study
Table S2 from Novel WRN Helicase Inhibitors Selectively Target Microsatellite-Unstable Cancer Cells
Authors: Picco Gabriele , Rao Yanhua , Al Saedi Angham , Lee Yang , Vieira Sara F. , Bhosle Shriram , May Kieron , Herranz-Ors Carmen , Walker Samantha J. , Shenje Raynold , Dincer Cansu , Gibson Freddy , Banerjee Ruby , Hewitson Zoe , Werner Thilo , Cottom Joshua E. , Peng Yang , Deng Nanhua , Zhang Youyou , Nartey Eldridge N. , Nickels Leng , Landis Philip , Conticelli Daniela , McCarten Katrina , Bush Jacob , Sharma Mamta , Lightfoot Howard , House David , Milford Emma , Grant Emma K. , Glogowski Michal P. , Wagner Craig D. , Bantscheff Marcus , Rutkowska-Klute Anna , Zappacosta Francesca , Pettinger Jonathan , Barthorpe Syd , Eberl H. Christian , Jones Brian T. , Schneck Jessica L. , Murphy Dennis J. , Voest Emile E. , Taygerly Joshua P. , DeMartino Michael P. , Coelho Matthew A. , Houseley Jonathan , Sharma Geeta , Schwartz Benjamin , Garnett Mathew J.
Published: August 2024

This table lists the results from Base editing screen
Supplementary Table 7 from Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
Authors: Pecci Federica , Nakazawa Seshiru , Ricciuti Biagio , Harada Guilherme , Lee Jessica K. , Alessi Joao V. , Barrichello Adriana , Vaz Victor R. , Lamberti Giuseppe , Di Federico Alessandro , Gandhi Malini M. , Gazgalis Dimitris , Feng William W. , Jiang Jie , Baldacci Simon , Locquet Marie-Anaïs , Gottlieb Felix H. , Chen Monica F. , Lee Elinton , Haradon Danielle , Smokovich Anna , Voligny Emma , Nguyen Tom , Goel Vikas K. , Zimmerman Zachary , Atwal Sumandeep , Wang Xinan , Bahcall Magda , Heist Rebecca S. , Iqbal Sumaiya , Gandhi Nishant , Elliott Andrew , Vanderwalde Ari M. , Ma Patrick C. , Halmos Balazs , Liu Stephen V. , Che Jianwei , Schrock Alexa B. , Drilon Alexander , Jänne Pasi A. , Awad Mark M.
Published: August 2024

Prevalence of MET tyrosine kinase domain (TKD) mutations among “other cancers” from Supplementary Table 6.
Figure S9 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer
Authors: Matusiak Magdalena , Hickey John W. , van IJzendoorn David G.P. , Lu Guolan , Kidziński Lukasz , Zhu Shirley , Colburg Deana R.C. , Luca Bogdan , Phillips Darci J. , Brubaker Sky W. , Charville Gregory W. , Shen Jeanne , Loh Kyle M. , Okwan-Duodu Derick K. , Nolan Garry P. , Newman Aaron M. , West Robert B. , van de Rijn Matt
Published: August 2024

This Figure is a visual summary of this work’s findings and shows the spatial distribution of distinct macrophage subsets in the tumor microenvironment and the clinical significance of IL4I1+ and SPP1+ macrophages in breast and colon tumors.
Supplementary Table 3 from Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
Authors: Pecci Federica , Nakazawa Seshiru , Ricciuti Biagio , Harada Guilherme , Lee Jessica K. , Alessi Joao V. , Barrichello Adriana , Vaz Victor R. , Lamberti Giuseppe , Di Federico Alessandro , Gandhi Malini M. , Gazgalis Dimitris , Feng William W. , Jiang Jie , Baldacci Simon , Locquet Marie-Anaïs , Gottlieb Felix H. , Chen Monica F. , Lee Elinton , Haradon Danielle , Smokovich Anna , Voligny Emma , Nguyen Tom , Goel Vikas K. , Zimmerman Zachary , Atwal Sumandeep , Wang Xinan , Bahcall Magda , Heist Rebecca S. , Iqbal Sumaiya , Gandhi Nishant , Elliott Andrew , Vanderwalde Ari M. , Ma Patrick C. , Halmos Balazs , Liu Stephen V. , Che Jianwei , Schrock Alexa B. , Drilon Alexander , Jänne Pasi A. , Awad Mark M.
Published: August 2024

Frequency of MET tyrosine kinase domain (TKD) mutations in cohort #2 according to amino acid residue, out of a total of 2,559 MET TKD mutations.
Figure S2 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer
Authors: Matusiak Magdalena , Hickey John W. , van IJzendoorn David G.P. , Lu Guolan , Kidziński Lukasz , Zhu Shirley , Colburg Deana R.C. , Luca Bogdan , Phillips Darci J. , Brubaker Sky W. , Charville Gregory W. , Shen Jeanne , Loh Kyle M. , Okwan-Duodu Derick K. , Nolan Garry P. , Newman Aaron M. , West Robert B. , van de Rijn Matt
Published: August 2024

This Figure illustrates spatial segregation of IL4I1+ vs FOLR2+ macrophages in BC and CRC tumor metastasis to the LN, and across eight different tumor types.
Figure S1 from Spatially Segregated Macrophage Populations Predict Distinct Outcomes in Colon Cancer
Authors: Matusiak Magdalena , Hickey John W. , van IJzendoorn David G.P. , Lu Guolan , Kidziński Lukasz , Zhu Shirley , Colburg Deana R.C. , Luca Bogdan , Phillips Darci J. , Brubaker Sky W. , Charville Gregory W. , Shen Jeanne , Loh Kyle M. , Okwan-Duodu Derick K. , Nolan Garry P. , Newman Aaron M. , West Robert B. , van de Rijn Matt
Published: August 2024

This Figure shows the distribution of scRNAseq macrophage clusters across different datasets, tissue locations, and tumor types.
Supplementary Table 20 from Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
Authors: Pecci Federica , Nakazawa Seshiru , Ricciuti Biagio , Harada Guilherme , Lee Jessica K. , Alessi Joao V. , Barrichello Adriana , Vaz Victor R. , Lamberti Giuseppe , Di Federico Alessandro , Gandhi Malini M. , Gazgalis Dimitris , Feng William W. , Jiang Jie , Baldacci Simon , Locquet Marie-Anaïs , Gottlieb Felix H. , Chen Monica F. , Lee Elinton , Haradon Danielle , Smokovich Anna , Voligny Emma , Nguyen Tom , Goel Vikas K. , Zimmerman Zachary , Atwal Sumandeep , Wang Xinan , Bahcall Magda , Heist Rebecca S. , Iqbal Sumaiya , Gandhi Nishant , Elliott Andrew , Vanderwalde Ari M. , Ma Patrick C. , Halmos Balazs , Liu Stephen V. , Che Jianwei , Schrock Alexa B. , Drilon Alexander , Jänne Pasi A. , Awad Mark M.
Published: August 2024

Clinicopathologic and genomic characteristics of 171 cases of cancers other than NSCLC harboring oncogenic / likely oncogenic MET TKD mutations in cohort #2.
Supplementary Table 16 from Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
Authors: Pecci Federica , Nakazawa Seshiru , Ricciuti Biagio , Harada Guilherme , Lee Jessica K. , Alessi Joao V. , Barrichello Adriana , Vaz Victor R. , Lamberti Giuseppe , Di Federico Alessandro , Gandhi Malini M. , Gazgalis Dimitris , Feng William W. , Jiang Jie , Baldacci Simon , Locquet Marie-Anaïs , Gottlieb Felix H. , Chen Monica F. , Lee Elinton , Haradon Danielle , Smokovich Anna , Voligny Emma , Nguyen Tom , Goel Vikas K. , Zimmerman Zachary , Atwal Sumandeep , Wang Xinan , Bahcall Magda , Heist Rebecca S. , Iqbal Sumaiya , Gandhi Nishant , Elliott Andrew , Vanderwalde Ari M. , Ma Patrick C. , Halmos Balazs , Liu Stephen V. , Che Jianwei , Schrock Alexa B. , Drilon Alexander , Jänne Pasi A. , Awad Mark M.
Published: August 2024

Comparison between clinicopathologic characteristic of NSCLCs with oncogenic / likely oncogenic MET tyrosine kinase domain (TKD) mutations without concurrent other drivers to NSCLCs with MET exon 14 alterations in cohort #2.
Supplementary Table 15 from Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
Authors: Pecci Federica , Nakazawa Seshiru , Ricciuti Biagio , Harada Guilherme , Lee Jessica K. , Alessi Joao V. , Barrichello Adriana , Vaz Victor R. , Lamberti Giuseppe , Di Federico Alessandro , Gandhi Malini M. , Gazgalis Dimitris , Feng William W. , Jiang Jie , Baldacci Simon , Locquet Marie-Anaïs , Gottlieb Felix H. , Chen Monica F. , Lee Elinton , Haradon Danielle , Smokovich Anna , Voligny Emma , Nguyen Tom , Goel Vikas K. , Zimmerman Zachary , Atwal Sumandeep , Wang Xinan , Bahcall Magda , Heist Rebecca S. , Iqbal Sumaiya , Gandhi Nishant , Elliott Andrew , Vanderwalde Ari M. , Ma Patrick C. , Halmos Balazs , Liu Stephen V. , Che Jianwei , Schrock Alexa B. , Drilon Alexander , Jänne Pasi A. , Awad Mark M.
Published: August 2024

Comparison between clinicopathologic characteristic of NSCLCs with oncogenic / likely oncogenic MET tyrosine kinase domain (TKD) mutations as a de novo genomic event to NSCLCs with MET exon 14 alterations in cohort #1.
Table S2 from ZNF397 Deficiency Triggers TET2-Driven Lineage Plasticity and AR-Targeted Therapy Resistance in Prostate Cancer
Authors: Xu Yaru , Yang Yuqiu , Wang Zhaoning , Sjöström Martin , Jiang Yuyin , Tang Yitao , Cheng Siyuan , Deng Su , Wang Choushi , Gonzalez Julisa , Johnson Nickolas A. , Li Xiang , Li Xiaoling , Metang Lauren A. , Mukherji Atreyi , Xu Quanhui , Tirado Carla R. , Wainwright Garrett , Yu Xinzhe , Barnes Spencer , Hofstad Mia , Chen Yu , Zhu Hong , Hanker Ariella B. , Raj Ganesh V. , Zhu Guanghui , He Housheng H. , Wang Zhao , Arteaga Carlos L. , Liang Han , Feng Felix Y. , Wang Yunguan , Wang Tao , Mu Ping
Published: August 2024

Table S2. Differentially Expressed Genes in ZNF397-KO Cells
Supplementary Figure 16 from Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
Authors: Pecci Federica , Nakazawa Seshiru , Ricciuti Biagio , Harada Guilherme , Lee Jessica K. , Alessi Joao V. , Barrichello Adriana , Vaz Victor R. , Lamberti Giuseppe , Di Federico Alessandro , Gandhi Malini M. , Gazgalis Dimitris , Feng William W. , Jiang Jie , Baldacci Simon , Locquet Marie-Anaïs , Gottlieb Felix H. , Chen Monica F. , Lee Elinton , Haradon Danielle , Smokovich Anna , Voligny Emma , Nguyen Tom , Goel Vikas K. , Zimmerman Zachary , Atwal Sumandeep , Wang Xinan , Bahcall Magda , Heist Rebecca S. , Iqbal Sumaiya , Gandhi Nishant , Elliott Andrew , Vanderwalde Ari M. , Ma Patrick C. , Halmos Balazs , Liu Stephen V. , Che Jianwei , Schrock Alexa B. , Drilon Alexander , Jänne Pasi A. , Awad Mark M.
Published: August 2024

Heavy atom root-mean-square deviation. Heavy atom root-mean-square deviation (RMSD) of each simulation: (A) MET wild-type, (B) MET H1094Y, (C) MET F1200I, and (D) R1170Q. Each frame is taken in a 0.1 ns interval.
Supplementary Figure 14 from Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
Authors: Pecci Federica , Nakazawa Seshiru , Ricciuti Biagio , Harada Guilherme , Lee Jessica K. , Alessi Joao V. , Barrichello Adriana , Vaz Victor R. , Lamberti Giuseppe , Di Federico Alessandro , Gandhi Malini M. , Gazgalis Dimitris , Feng William W. , Jiang Jie , Baldacci Simon , Locquet Marie-Anaïs , Gottlieb Felix H. , Chen Monica F. , Lee Elinton , Haradon Danielle , Smokovich Anna , Voligny Emma , Nguyen Tom , Goel Vikas K. , Zimmerman Zachary , Atwal Sumandeep , Wang Xinan , Bahcall Magda , Heist Rebecca S. , Iqbal Sumaiya , Gandhi Nishant , Elliott Andrew , Vanderwalde Ari M. , Ma Patrick C. , Halmos Balazs , Liu Stephen V. , Che Jianwei , Schrock Alexa B. , Drilon Alexander , Jänne Pasi A. , Awad Mark M.
Published: August 2024

Western blot analysis of MET and ERK1/2 phosphorylation in MET R1170Q cell models. MET and ERK1/2 phosphorylation in (A) Ba/F3 cells stably transduced with MET R1170Q and (B) 293T cells transiently overexpressing MET R1170Q. Cells were treated with MET TKIs at the indicated dose for Ba/F3 cells or at 1 μM for 293T cells.
Supplementary Figure 12 from Activating Point Mutations in the MET Kinase Domain Represent a Unique Molecular Subset of Lung Cancer and Other Malignancies Targetable with MET Inhibitors
Authors: Pecci Federica , Nakazawa Seshiru , Ricciuti Biagio , Harada Guilherme , Lee Jessica K. , Alessi Joao V. , Barrichello Adriana , Vaz Victor R. , Lamberti Giuseppe , Di Federico Alessandro , Gandhi Malini M. , Gazgalis Dimitris , Feng William W. , Jiang Jie , Baldacci Simon , Locquet Marie-Anaïs , Gottlieb Felix H. , Chen Monica F. , Lee Elinton , Haradon Danielle , Smokovich Anna , Voligny Emma , Nguyen Tom , Goel Vikas K. , Zimmerman Zachary , Atwal Sumandeep , Wang Xinan , Bahcall Magda , Heist Rebecca S. , Iqbal Sumaiya , Gandhi Nishant , Elliott Andrew , Vanderwalde Ari M. , Ma Patrick C. , Halmos Balazs , Liu Stephen V. , Che Jianwei , Schrock Alexa B. , Drilon Alexander , Jänne Pasi A. , Awad Mark M.
Published: August 2024

Sensitivity pattern of MET TKD mutations in 293T cells. (A) ERK-mediated transcriptional activation assessed by luciferase assay in 293T cells co-transfected with MET WT or TKD mutant constructs, an ERK activation reporter vector (pGL4.33), and a control co-reporter vector (pRL-TK). The lower panel shows western blot analysis of transfected samples. (B) Western blot analysis of MET and ERK1/2 phosphorylation in response to 1 μM crizotinib. MET TKD mutants showing sensitivity and resistance to crizotinib are colored in green and orange, respectively.
Figure S3 from Lifileucel, an Autologous Tumor-Infiltrating Lymphocyte Monotherapy, in Patients with Advanced Non–Small Cell Lung Cancer Resistant to Immune Checkpoint Inhibitors
Authors: Schoenfeld Adam J. , Lee Sylvia M. , Doger de Spéville Bernard , Gettinger Scott N. , Häfliger Simon , Sukari Ammar , Papa Sophie , Rodríguez-Moreno Juan F. , Graf Finckenstein Friedrich , Fiaz Rana , Catlett Melissa , Chen Guang , Qi Rongsu , Masteller Emma L. , Gontcharova Viktoria , He Kai
Published: August 2024

Circulating tumor DNA analysis
Supplementary Table S4 from St. Jude Survivorship Portal: Sharing and Analyzing Large Clinical and Genomic Datasets from Pediatric Cancer Survivors
Authors: Matt Gavriel Y. , Sioson Edgar , Shelton Kyla , Wang Jian , Lu Congyu , Zaldivar Peraza Airen , Gangwani Karishma , Paul Robin , Reilly Colleen , Acić Aleksandar , Liu Qi , Sandor Stephanie R. , McLeod Clay , Patel Jaimin , Wang Fan , Im Cindy , Wang Zhaoming , Sapkota Yadav , Wilson Carmen L. , Bhakta Nickhill , Ness Kirsten K. , Armstrong Gregory T. , Hudson Melissa M. , Robison Leslie L. , Zhang Jinghui , Yasui Yutaka , Zhou Xin
Published: August 2024

Associations of haplotypes with cardiomyopathy
Supplementary Table S6 from Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth Through Stabilizing BRD2
Authors: Chen Lishu , Qi Qinghui , Jiang Xiaoqing , Wu Jin , Li Yuanyuan , Liu Zhaodan , Cai Yan , Ran Haowen , Zhang Songyang , Zhang Cheng , Wu Huiran , Cao Shuailiang , Mi Lanjuan , Xiao Dake , Huang Haohao , Jiang Shuai , Wu Jiaqi , Li Bohan , Xie Jiong , Qi Ji , Li Fangye , Liang Panpan , Han Qiuying , Wu Min , Zhou Wenchao , Wang Chenhui , Zhang Weina , Jiang Xin , Zhang Kun , Li Huiyan , Zhang Xuemin , Li Ailing , Zhou Tao , Man Jianghong
Published: August 2024

Supplementary Table S6 shows the sequences of shRNAs used in this study.
Supplementary Table S5 from Phosphocreatine Promotes Epigenetic Reprogramming to Facilitate Glioblastoma Growth Through Stabilizing BRD2
Authors: Chen Lishu , Qi Qinghui , Jiang Xiaoqing , Wu Jin , Li Yuanyuan , Liu Zhaodan , Cai Yan , Ran Haowen , Zhang Songyang , Zhang Cheng , Wu Huiran , Cao Shuailiang , Mi Lanjuan , Xiao Dake , Huang Haohao , Jiang Shuai , Wu Jiaqi , Li Bohan , Xie Jiong , Qi Ji , Li Fangye , Liang Panpan , Han Qiuying , Wu Min , Zhou Wenchao , Wang Chenhui , Zhang Weina , Jiang Xin , Zhang Kun , Li Huiyan , Zhang Xuemin , Li Ailing , Zhou Tao , Man Jianghong
Published: August 2024

Supplementary Table S5 shows the detailed genetic mutations of four GBM cell lines.
Supplementary Figure S1 from St. Jude Survivorship Portal: Sharing and Analyzing Large Clinical and Genomic Datasets from Pediatric Cancer Survivors
Authors: Matt Gavriel Y. , Sioson Edgar , Shelton Kyla , Wang Jian , Lu Congyu , Zaldivar Peraza Airen , Gangwani Karishma , Paul Robin , Reilly Colleen , Acić Aleksandar , Liu Qi , Sandor Stephanie R. , McLeod Clay , Patel Jaimin , Wang Fan , Im Cindy , Wang Zhaoming , Sapkota Yadav , Wilson Carmen L. , Bhakta Nickhill , Ness Kirsten K. , Armstrong Gregory T. , Hudson Melissa M. , Robison Leslie L. , Zhang Jinghui , Yasui Yutaka , Zhou Xin
Published: August 2024

Design and architecture of the St. Jude Survivorship Portal
Stroke Rehabilitation Clinical Practice Guidelines in Low- and Middle-Income Countries: A Systematic Review of Quality and Unique Features
Authors: Gandhi Dorcas B.C. , Kamalakannan Sureshkumar , Urimubenshi Gerard , Sebastian Ivy A. , Montanaro Vinicius V.A. , Chawla Nistara S. , D'souza Jennifer V. , Ngeh Etienne , Mahmood Amreen , Demers Marika , Hombali Aditi , Solomon John M. ,   on behalf of GCSR Collaborators
Published: August 2024

Introduction: Efforts toward reducing stroke burden have been an immense challenge. One important reasons could be the scope and quality of clinical practice guidelines (CPGs) developed for stroke rehabilitation in low- and middle-income countries (LMICs), restricting its translation to clinical practice. This systematic review aimed to assess the availability, scope and quality of CPGs for stroke rehabilitation in LMICs. Methods: Following PRISMA guidelines, CPGs for stroke rehabilitation in LMICs were searched across four major electronic databases (Medline, Embase, CINAHL, and PEDro). Additional studies were identified from grey literature and a hand search of key bibliographies and search engines. The availability and content of the CPGs were narratively summarized and quality of de novo CPGs was analyzed using “Appraisal of Guidelines REsearch and Evaluation” (AGREE) tools: version II & Recommendations Excellence (REX) version. Features of contextualizations/adaptations of non-de novo CPGs were narratively summarized. Results: Twelve CPGs from 10 countries were included. CPGs from Pakistan, Sri Lanka, India, and China were developed de novo. CPGs from Kenya, Philippines, South Africa, Cameroon, Mongolia, and Ukraine were contextualized/adapted based on existing guidelines from high-income countries. Most contextualized CPGs had limited stakeholder involvement, local health systems/patient pathway analyses. All ten countries included recommendations for physiotherapy, seven for communication, swallowing, and five for occupational therapy services poststroke. Quality assessment using AGREE-REX and AGREE-II for de novo guidelines was poor, especially scoring low in development and applicability. Conclusion: Contextualized CPGs for stroke rehabilitation in LMICs were scarcely available and not meeting required quality. There is a need for development of context-specific, culturally relevant CPGs for stroke rehabilitation in LMICs to improve implementation/translation into clinical practice.
A administração da defesa civil no Direito brasileiro
Authors: França Vladimir da Rocha
Published: August 2024

The present work aims to analyze the constitutional and federal legal models of civil defense adopted in Brazilian Law, taking civil defense as a premise as a manifestation of the State's administrative activity. The legal concept of civil defense is exposed, the way in which the competencies that are pertinent to them are outlined in the current legal system, and the rights of those administered regarding control of the administration and the civil liability of the State. To this end, the methodology recommended by Legal Dogmatics (or Science of Law in the strict sense) is used, which chooses as its object the system of Positive Law that is in force.
Infraestruturas de saneamento básico na Amazônia Legal: a Lei 14.026/2020 e os desafios da universalização
Authors: Figueiredo Alexandre Ganan de Brites , Narita Beatriz Sakuma , Toneto Júnior Rudinei
Published: August 2024

This research intends to discuss the innovations in the regulation of basic sanitation brought about by Brazilian Federal Law nº 14,026/2020, focusing on the nine states that make up the Brazilian Amazon: Acre, Amapá, Amazonas, Mato Grosso, Maranhão, Pará, Rondônia, Roraima and Tocantins. More specifically, it is intended to inquire whether the hope in the performance of the private sector thanks to the innovations of regionalization, the proof of economic-financial capacity, the prohibition of program contracts and the consequent determination of tenders are adequate and contribute to overcoming the deficit in sanitation in that region. In this sense, the consequences of decree 10,710/2021 will be mainly presented. Finally, the dissemination of Public-Private Partnerships (PPPs) on sanitation will also be addressed as a viable alternative for achieving universalization goals in a model that combines the public and private spheres.
Being is to be perceived: an x-ray of the high-level w om en handball athletes’ body image in Brazil
Authors: Knijnik Jorge Dorfman , Simões Antonio Carlos
Published: August 2024

Este estudo teve como objetivo pesquisar, no âmbito das equipes femininas de handebol de alto nível do Brasil, a imagem corporal de suas atletas. Apesar da presença da mulher no meio esportivo nunca ter sido tão grande como na atualidade, vários preconceitos ainda incomodam as atletas de alto rendimento, notadamente aqueles vinculados às imagens e formas de seus corpos. Utilizando-se um referencial teórico fenomenológico, procura-se aqui compreender o corpo de uma perspectiva não dualista. O instrumento utilizado na pesquisa foi o “inventário para avaliação da imagem corporal das atletas de handebol de alto nível no Brasil” o qual, a partir de 65 frases, compara a imagem corporal real da atleta com aquela idealizada por esta. Participaram do estudo 156 atletas de handebol de alto nível, com idades entre 14 e 33 anos (média de 20,26 anos). Como resultados, encontraram-se diferenças estatisticamente significantes entre a imagem corporal real e a ideal em 35 (= 54%) das proposições do questionário, em diversas dimensões da imagem corporal. Este estudo corrobora pesquisas feitas internacionalmente, as quais mostram que as mulheres, para se manter no esporte de alto nível, precisam perpetuar características estereotipadas como femininas, mesmo que estas se choquem com as necessidades corporais de sua modalidade
The engagement of the cerebellum and basal ganglia enhances expertise in a sensorimotor adaptation task
Authors: Tan Joshua B. , Müller Eli , Zahorodnii Andrii , Shine James M.
Published: August 2024

The ability to adapt to changes in the environment is essential for skilled performance, especially in competitive sports and events, where experts consistently perform at the highest level, rapidly adapting to unpredictable conditions. Current studies have identified cortical-cortical interactions between the premotor and primary motor cortex during expert performance; however, while these interactions are important for planning and execution, our understanding of the mechanisms underlying learning, feedback, and adaptation remains unclear. Subcortical structures, such as the cerebellum, have dense connections with the cerebral cortex through which they provide precise topological constraints that could putatively play a crucial role in fast, accurate task execution. To test this hypothesis, we tracked cortical, subcortical, and cerebellar BOLD activity during a visuomotor rotation task in which participants executed a visual cue-driven, ballistic motor task across three conditions: at baseline; following a 45° clockwise motor rotational perturbation; and then within a follow-up (washout) condition. We observed increased recruitment of primary visual, basal ganglia, and cerebellar regions that robustly covaried with fast, accurate performance across all conditions (baseline, rotation, and washout). Tracking individualised performance across participants, we observed three distinct groups: experts (consistently fast and accurate), adapters (initially poor with improvement to expert-level), and non-adapters (initially good but ultimately poor performance). The experts and adapter groups demonstrated performances that were robust to changes in conditions and were more variable in their neural signatures between trials, whereas the performance of non-adapters decreased with changes in conditions and were characterised by less variable neural signatures. These results aligned with the tenets of the differential learning theory. To establish the validity of our interpretation of these whole-brain signatures and behavioural patterns, the neuroimaging results were reproduced by training recurrent neural networks representing each group and analysing their resultant activity patterns. Together, these results provide evidence for cerebellar and basal ganglia contributions to expertise in adaptation and suggest a possible connection between variable brain patterns and robust performance.
Postpragmatism: Quine, Rorty, and a thoroughgoing Atheoreticism
Authors: Piacente Albert
Published: August 2024

This paper develops the pragmatic “atheoreticism” of Quine and Rorty. A position I dub “postpragmatism”—paralleling the post phases of modernism and humanism—my purpose here is to bring to a culmination what Quine and Rorty started decades before. By doing so, I argue, it becomes possible for Quine, and more so Rorty, to avoid the most common critiques of their atheoretic form of pragmatism. Chief among them, that it is mired in self-contradiction. Rather than rely upon theory to justify atheoreticism—the very stuff of their self-contradiction—I rely instead upon Rorty’s own insouciance, syncretism, and eclecticism to shift the ground of debate from concern with what is justified to concern with what is interesting.
Democracy as Communication: Towards a Normative Framework for Evaluating Digital Technologies
Authors: Coeckelbergh Mark
Published: August 2024

Are current digital technologies supporting democracy? Answering that question depends, among other things, on what is meant by democracy. This article mobilizes a communicative conception of democracy. While it is generally accepted that communication is important for democracy, there are directions in democracy theory that understand communication as not merely instrumental but as central to what democracy is and should be. Inspired by Dewey, Habermas, and Young, this paper articulates a conception of democracy as communication. It is then argued that this “deep-communicative” ideal of democracy, together with the usual ethical and epistemic norms of communication as sketched by O’Neill, offer a tentative normative framework for evaluating digital technologies in relation to democracy.