bluuebunny/crossref_metadata_2025 huggingface dataset:
Medication-Related Osteonecrosis of the Jaw: A Cross-Sectional Survey among Urologists in Switzerland, Germany, and Austria
Authors: Calderaro Salvatore , Bausch Kathrin , Tourbier Céline , Wetterauer Christian , Thieringer Florian M. , Berg Britt-Isabelle
Published: January 2023

Medication-related osteonecrosis of the jaw (MRONJ) is a potentially preventable adverse side effect of mainly antiresorptive drugs. MRONJ is expected to become a growing clinical problem due to the aging population and the increasing number of patients requiring antiresorptive agents. Knowledge and awareness about MRONJ and elimination of the oral and dental risk factors before starting antiresorptive therapy (AR) are fundamental to reducing the incidence of MRONJ. In urology, ARs are used primarily in patients suffering from bone metastases due to prostate cancer and to prevent cancer-treatment-induced bone loss (CTIBL) in prostate cancer patients receiving endocrine therapy. This postal survey aimed to evaluate disease-related knowledge and awareness about implementing oral examinations for patients starting AR among Swiss, German, and Austrian urologists. A total of 176 urologists returned the completed questionnaire, yielding a response rate of 11.7%. Of the respondents, 44.9% (n = 79) and 24.4% (n = 43) stated that they give more than five first-time prescriptions of denosumab and of intravenous or oral bisphosphonates per year, respectively. Only 14.8% (n = 26) of the participating urologists had never encountered MRONJ cases related to BPs. Of the participants, 89.8% (n = 158) had implemented referrals to dentists for oral examination before initiating AR. The mean percentage of correct answers regarding the knowledge about MRONJ was 70.9% ± 11.2%. In contrast to previous surveys on MRONJ among physicians, this study showed that the participating urologists were sufficiently informed about MRONJ, as reflected by the high number of participants implementing preventive dental screenings.
Quantitative CT Metrics for the Prediction of Therapeutic Effect in Asthma
Authors: Ma Donghai , Shi Honglei , Tan Cuiyan , Zou Wei , Sun Fengfei , Wang Kongqiu , Lei Qianqian , Zheng Xiaobin , Zhong Yuanyuan , Tu Changli , Chen Meizhu , Huang Yiying , Wang Zhenguo , Wu Jian , Liang Yingjian , Liu Jing
Published: January 2023

Background: Few studies have explored the correlation between asthma medication and features on HRCT images. We aim to analyse the differences and temporal changes of lung function and airway resistance in asthma with diverse HRCT phenotypes in a short period after inhalation of budesonide/formoterol. Method: This observational study recruited 55 adult patients with varying severities of asthma. We performed detailed airway metrics measurements of chest CT scans, such as airway wall thickness (WT), wall area percentage (WA%), wall thickness percentage (T/OR), and airways with an inner perimeter of 10 mm (Pi10). The effect of lung structural features on asthma medication response was explored according to the WA% and T/OR twelve hours post-drug administration. Using multivariable regression models, we then assessed the influence of WA% on lung function. Results: WA% (p < 0.001) and T/OR (p < 0.001) significantly increased in asthma than in healthy control subjects. Compared to mild asthma, airway walls were further thickened (WA%, p = 0.023; T/OR: p = 0.029) and associated with lumen narrowing (Pi10, p = 0.055) in moderate to severe asthma. WA% and T/OR correlated well with lung function (FEV1, FVC, MMEF, and PEF) and airway resistance (R5, R20, Rp, and Fres). Regression analysis showed that MEF25 decreased with increasing age and WA% (R2 = 0.58, p < 0.001). Patients with thickened airway walls experienced a maximal increase in FVC, FEV1, and PEF at 2 h (p < 0.001) and a maximal decrease of R5, Z5, and Rp at 2 h (p < 0.001) in those with a thickened airway pattern. Conclusions: Asthma patients with different bronchial wall thicknesses exhibited variable lung function changes. Specifically, patients with thick airway wall patterns were more sensitive to inhaled budesonide in the short term.
Comparing Post-Exercise Hypotension after Different Sprint Interval Training Protocols in a Matched Sample of Younger and Older Adults
Authors: Ketelhut Sascha , Möhle Martin , Gürlich Tina , Hottenrott Laura , Hottenrott Kuno
Published: January 2023

This study assessed the post-exercise hypotension (PEH) effect in a sample of matched young and older adults after different sprint interval training (SIT) protocols. From forty-three participants enrolled in this study, twelve younger (24 ± 3 years) and 12 older (50 ± 7 years) participants, matched for the body mass index, systolic blood pressure, and VO2max-percentiles, were selected. The participants completed two SIT protocols consisting of 4 × 30 s exercise bouts interspersed by either one (SIT1) or three minutes (SIT3) of active rest. The peripheral systolic (pSBP) and diastolic (pDBP) blood pressure, central systolic (cSBP) and diastolic (cDBP) blood pressure, pulse wave velocity (PWV), and heart rate (HR) were obtained before and at different measurement time points (t5, t15, t30, t45) after the exercise. No significant time × group interactions were detected in pSBP (p = 0.242, η² = 0.060), pDBP (p = 0.379, η² = 0.046), cSBP (p = 0.091, η² = 0.861), cDBP (p = 0.625, η² = 0.033), PWV (p = 0.133, η² = 0.076), and HR (p = 0.190, η² = 0.123) after SIT1. For SIT3 no significant time × group interactions could be detected for pSBP (p = 0.773, η² = 0.020), pDBP (p = 0.972, η² = 0.006), cSBP (p = 0.239, η² = 0.060), cDBP (p = 0.535, η² = 0.036), PWV (p = 0.402, η² = 0.044), and HR (p = 0.933, η² = 0.009). Matched samples of young and older adults reveal similar PEH effects after HIIT. Accordingly, age does not seem to affect PEH after SIT. These results show that rest interval length and age modulate the PEH effect after SIT.
Return to Work after Breast Reduction: A Comparative Study
Authors: Holopainen Nora , Oranges Carlo M. , di Summa Pietro G. , Toia Francesca , Giordano Salvatore
Published: January 2023

(1) Background: Breast hypertrophy is a prevalent condition among women worldwide, which can affect different aspects of their quality of life. Uncertainty exists in the medical literature about recommendations for return to work after reduction mammaplasty procedures. The aim of this study was to assess the return to work after reduction mammaplasty for women with breast hypertrophy. (2) Methods: A retrospective cohort study composed of chart review of all reduction mammaplasties performed at a single institution due to breast hypertrophy was considered. Patients not in working life were excluded. Patients were divided into two groups based on the sick leave duration: normal versus prolonged. Prolonged sick leave time was defined as times greater than the 75th percentile for the respective sample data. Demographic and comorbidity data were secondary predictor variables. The primary outcome measure was the occurrence of prolonged sick leave. Secondary endpoints were specific wound healing complications and late complications. We further compare postoperative complications between patients who received a sick leave of 3 weeks versus the other patient cohort. (3) Results: From a total of 490 patients, 407 of them were employed at intake. Mean time to working return after reduction mammaplasty was 4.0 ± 0.9 weeks. Prolonged sick leave occurred in 77 patients and its mean duration was 5.5 ± 0.9 weeks. No differences in age, preoperative BMI, smoking, comorbidities, number of children or use of herbal supplements were detected. Significantly increased intraoperative blood loss occurred in the group who received prolonged sick leave (328.3 mL vs. 279.2 mL, p = 0.031). Postoperative complications were significantly higher in the group who experienced a prolonged sick leave (26.5% vs. 11.2%, p < 0.001), particularly infections and wound dehiscence incidences. No differences in late complications were detected (>30 days, 6.5% vs. 7.6%, p = 0.729). When comparing patients who received a 3 week sick leave with the rest of cohort, blood loss was significantly higher in the group who had a longer sick leave (230.9 mL vs. 303.7 mL, p < 0.001). (4) Conclusions: The occurrence of postoperative complications increased the patients’ return to work time. Comorbidities and preoperative parameters did not affect the length of sick leave. It appears reasonable to suggest a recovery period of approximately 3 weeks, subject to individual variations. An increased intraoperative blood loss might predict a prolonged sick leave.
The Epidemiology of Pre-Hospital EMS Treatment of Geriatric Patients in the City of Vienna—An Overview
Authors: Krammel Mario , Drahohs Valentin , Hamp Thomas , Lemoyne Sabine , Grassmann Daniel , Schreiber Wolfgang , Sulzgruber Patrick , Schnaubelt Sebastian
Published: January 2023

Background: The city of Vienna, Austria, has a gradually aging population. Elderly people, over 65 years old and living at home or in nursing homes, frequently use Emergency Medical Services (EMS). However, there is no previous data comparing the EMS utilization of elderly- and non-elderly patients in Vienna. Methods: We retrospectively analyzed all EMS incidents in Vienna from 2012 to 2019. Transport- and emergency physician treatment rates, annual fluctuations, and the number of non-transports were compared between elderly (≥65 years) and non-elderly (18–64 years) patients. Results: Elderly people accounted for 42.6% of the total EMS responses in adult patients, representing an annual response rate of 223 per 1000 inhabitants ≥ 65 years. Compared to 76 per 1000 inhabitants in patients 18–64 years old, this results in an incidence rate ratio (IRR) of 2.93 [2.92–2.94]. Elderly people were more likely (OR 1.68 [1.65–1.70]) to need emergency physicians, compared to 18–64 year-olds. Nursing home residents were twice (OR 2.11 [2.06–2.17]) as likely to need emergency physicians than the rest of the study group. Non-transports were more likely to occur in patients over 65 years than in non-elderlies (14% vs. 12%, p < 0.001). Conclusions: The elderly population ≥ 65 years in Vienna shows higher EMS response rates than younger adults. They need emergency physicians more often, especially when residing in nursing homes. The economical and organizational strain this puts on the emergency response system should trigger further research and the development of solutions, such as specific response units dedicated to elderly people.
Human Leucocyte Antigen System and Selection of Unrelated Hematopoietic Stem Cell Donors: Impact of Patient–Donor (Mis)matching and New Challenges with the Current Technologies
Authors: Crocchiolo Roberto , Rombolà Gianni
Published: January 2023

The selection of hematopoietic stem cell donors for allogeneic transplantation (allo-HSCT) is mainly driven by human leucocyte antigen (HLA) matching between patient and donor, with HLA-identical matched siblings being the preferred choice in most situations. Although other clinical and demographical variables matter, especially, donor age, which is unequivocally associated with better transplant outcomes, the histocompatibility criteria have a central role in the search for the best donor, particularly in the setting of unrelated allo-HSCT where HLA disparities between patient and donor are frequent. The present review is focused on the role of HLA incompatibilities on patient outcome according to the most recent literature, in an attempt to guide transplant physicians and search coordinators during the process of adult unrelated-donor selection. The technological progresses in HLA typing, i.e., with next-generation sequencing (NGS), now allow disclosing a growing number of HLA incompatibilities associated with a heterogeneous and sometimes unknown spectrum of clinical severity. Their immunogenic characteristics, i.e., their position inside or outside the antigen recognition domain (ARD), their permissiveness, their intronic or exonic nature and even the expected expression of the HLA loci where those mismatches occur, will be presented and discussed here, integrating the advances in the immunobiology of transplantation with survival and toxicity outcomes reported in the most relevant studies, within the perspective of improving donor selection in the current practice.
Association between Serum Uric Acid and Liver Enzymes in Adults Aged 20 Years and Older in the United States: NHANES 2005–2012
Authors: Lin Hong , Dai Guoyou , Huang Song , Chen Zhaoyang , Jin Zhaohui , He Zhiyao
Published: January 2023

Although the relationship between serum uric acid (SUA) and nonalcoholic fatty liver disease has been widely reported, the relationship between SUA and liver enzymes has rarely been reported. The purpose of this study was to evaluate the association of SUA levels with alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in populations aged 20 years and older in the United States. We analyzed 7165 individuals aged 20 years and older from the National Health and Nutrition Examination Survey (NHANES) in the United States. Weighted multiple linear regression models were used to analyze the relationship between SUA and ALT and AST. A generalized additive model and a smooth curve fitting were used to observe the linear relationship. SUA was positively correlated with ALT and AST. In addition, the overall increasing trend of ALT and SUA was observed across the SUA quartile groups. In the stratified analysis by sex and race, the SUA levels in male, female, Mexican American, and Non-Hispanic White individuals, and those of another race, were positively correlated with ALT and AST. However, the SUA levels in Non-Hispanic Black individuals had a nonlinear relationship with ALT and AST. In individuals aged 20 years and older in the United States (excluding Non-Hispanic Black individuals), SUA levels were positively associated with ALT and AST. Therefore, with a rise in SUA levels, liver function should be monitored or intervened with in people aged 20 years and older in the United States.
Enhanced Antibacterial Effect on Zirconia Implant Abutment by Silver Linear-Beam Ion Implantation
Authors: Yang Yang , Liu Mingyue , Yang Zhen , Lin Wei-Shao , Chen Li , Tan Jianguo
Published: January 2023

Peri-implant lesions, such as peri-implant mucositis and peri-implantitis, are bacterial-derived diseases that happen around dental implants, compromising the long-term stability and esthetics of implant restoration. Here, we report a surface-modification method on zirconia implant abutment using silver linear-beam ion implantation to reduce the bacterial growth around the implant site, thereby decreasing the prevalence of peri-implant lesions. The surface characteristics of zirconia after ion implantation was evaluated using energy dispersive spectroscopy, X-ray photoelectron spectroscopy, and a contact-angle device. The antibacterial properties of implanted zirconia were evaluated using Streptococcus mutans and Porphyromonas gingivalis. The biocompatibility of the material surface was evaluated using human gingival fibroblasts. Our study shows that the zirconia surface was successfully modified with silver nanoparticles by using the ion-implantation method. The surface modification remained stable, and the silver-ion elution was below 1 ppm after one-month of storage. The modified surface can effectively eliminate bacterial growth, while the normal gingiva’s cell growth is not interfered with. The results of the study demonstrate that a silver-ion-implanted zirconia surface possesses good antibacterial properties and good biocompatibility. The surface modification using silver-ion implantation is a promising method for future usage.
Acknowledgment to the Reviewers of Journal of Intelligence in 2022
Authors:   Journal of Intelligence Editorial Office
Published: January 2023

High-quality academic publishing is built on rigorous peer review [...]
A Novel Damage Identification Method for Steel Catenary Risers Based on a Novel CNN-GRU Model Optimized by PSO
Authors: Liu Zhongyan , Mei Jiangtao , Wang Deguo , Guo Yanbao , Wu Lei
Published: January 2023

As a new type of riser connecting offshore platforms and submarine pipelines, steel catenary risers (SCRs) are generally subject to waves and currents for a long time, thus it is significant to fully evaluate the SCR structure’s safety. Aiming at the damage identification of the SCR, the acceleration time series signals at multiple locations are taken as the damage characteristics. The damage characteristics include spatial information of the measurement point location and time information of the acquisition signal. Therefore, a convolutional neural network (CNN) is employed to obtain spatial information. Considering the variable period characteristics of the acceleration time series of the SCR, a gated recurrent unit (GRU) neural network is utilized to study these characteristics. However, neither a single CNN nor GRU model can simultaneously obtain temporal and spatial data information. Therefore, by combining a CNN with a GRU, the CNN-GRU model is established. Moreover, the hyperparameters of deep learning models have a significant influence on their performance. Therefore, particle swarm optimization (PSO) is applied to solve the hyperparameter optimization problem of the CNN-GRU. Thus, the PSO-CNN-GRU (PCG) model is established. Subsequently, an SCR damage identification method based on the PCG model is presented to predict the damage location and degree by SCR acceleration time series. By analyzing the SCR acceleration data, the prediction performances of the PCG model and the PSO optimization capacity are verified. The experimental results indicate that the identification result of the proposed PCG model is better than that of several existing models (CNN, GRU, and CNN-GRU).
An Evaluation of the Efficiency of the Floating Solar Panels in the Western Black Sea and the Razim-Sinoe Lagunar System
Authors: Manolache Alexandra Ionelia , Andrei Gabriel , Rusu Liliana
Published: January 2023

The development of novel solar power technologies is regarded as one of the essential solutions to meeting the world’s rising energy demand. Floating photovoltaic panels (FPV) have several advantages over land-based installations, including faster deployment, lower maintenance costs, and increased efficiency. Romania is considered a country with enormous solar energy potential, which is one of the most exploited sectors of the renewable energy sector. With this in mind, the purpose of this work is to assess the energetic potential provided by the sun, taking into account three lakes in Romania’s east and extending to the west of the Black Sea. In this context, we examine the hourly distribution of solar radiation for the year 2021. The solar radiation data were extracted using the ERA5 database, as well as data collected in situ near them. Following this research, we discovered that all of the chosen locations have a high energetic potential and could be used as locations for the exploitation of solar energy, thereby avoiding the use of land that could be used for agricultural purposes in these areas. We also noticed that there are minor differences between the solar radiation values obtained from the ERA5 database and the measured ones.
A Simple Bias Correction Scheme in Ocean Data Assimilation
Authors: Yan Changxiang , Zhu Jiang
Published: January 2023

The mode bias is present and time-dependent due to imperfect configurations. Data assimilation is the process by which observations are used to correct the model forecast, and is affected by the bias. How to reduce the bias is an important issue. This paper investigates the roles of a simple bias correction scheme in ocean data assimilation. In this scheme, the misfits between modeled and monthly temperature and salinity with interannual variability from the Met Office Hadley Centre subsurface temperature and salinity data set (EN4.2.2) are used for the innovations in assimilation via the Ensemble Optimal Interpolation method. Two assimilation experiments are implemented to evaluate the impacts of bias correction. The first experiment is a data assimilation system without bias correction. In the second experiment, the bias correction is applied in assimilation. For comparison, the nature run with no assimilation and no bias correction is also conducted. When the bias correction is not applied, the assimilation alone leads to a rising trend in the heat and salt content that is not found in the observations. It is a spurious temporal variability due to the effect of the bias on the data assimilation. Meanwhile, the assimilation experiment without bias correction also produces significant negative impacts on the subsurface salinity. The experiment with bias correction performs best with notable improvements over the results of the other two experiments.
Differences in the Fate of Surface and Subsurface Microplastics: A Case Study in the Central Atlantic
Authors: Zhdanov Igor , Pakhomova Svetlana , Berezina Anfisa , Silvestrova Ksenia , Stepanova Natalia , Yakushev Evgeniy
Published: January 2023

Plastic is recognized as a threat to marine ecosystems, and estimating the level of plastic and microplastics (MPs) pollution of the World Ocean is, nowadays, the goal of many studies. However, the use of different methods for the sampling and analysis of MPs leads to the problem of comparing the results obtained. Studies on surface MPs pollution of the surface sea water are based on the application of the manta or neuston nets that collect water from the upper 10–20 cm layer (the “surface” MPs) or submersible pumping systems that collect water from the water layer 3 to 5 m below the sea surface (the “subsurface” MPs). These two techniques allow the collection of particles of different size fractions, i.e., >300 µm for the surface MPs and >100 µm for the subsurface MP. However, it is shown that microplastics found in the surface and subsurface layers differ not only in the size of the items found, but also in morphology, types of polymers, abundance, weight concentration and their spatial distribution. Different hydrodynamic processes affect the fate of the plastic found exactly at the sea surface and several meters deeper. The aim of this work was to study the distribution of surface and subsurface MPs and to reveal an influence of oceanographic conditions on their spatial distribution, using as an example the open ocean waters of the Central Atlantic.
Maternity Blues: A Narrative Review
Authors: Tosto Valentina , Ceccobelli Margherita , Lucarini Emanuela , Tortorella Alfonso , Gerli Sandro , Parazzini Fabio , Favilli Alessandro
Published: January 2023

Puerperium is a period of great vulnerability for the woman, associated with intense physical and emotional changes. Maternity blues (MB), also known as baby blues, postnatal blues, or post-partum blues, include low mood and mild, transient, self-limited depressive symptoms, which can be developed in the first days after delivery. However, the correct identification of this condition is difficult because a shared definition and well-established diagnostic tools are not still available. A great heterogenicity has been reported worldwide regarding MB prevalence. Studies described an overall prevalence of 39%, ranging from 13.7% to 76%, according to the cultural and geographical contexts. MB is a well-established risk factor for shifting to more severe post-partum mood disorders, such as post-partum depression and postpartum psychosis. Several risk factors and pathophysiological mechanisms which could provide the foundation of MB have been the object of investigations, but only poor evidence and speculations are available until now. Taking into account its non-negligible prevalence after childbirth, making an early diagnosis of MB is important to provide adequate and prompt support to the mother, which may contribute to avoiding evolutions toward more serious post-partum disorders. In this paper, we aimed to offer an overview of the knowledge available of MB in terms of definitions, diagnosis tools, pathophysiological mechanisms, and all major clinical aspects. Clinicians should know MB and be aware of its potential evolutions in order to offer the most timely and effective evidence-based care.
Current and Potential Future Distribution of Endemic Salvia ceratophylloides Ard. (Lamiaceae)
Authors: Laface Valentina Lucia Astrid , Musarella Carmelo Maria , Tavilla Gianmarco , Sorgonà Agostino , Cano-Ortiz Ana , Quinto Canas Ricardo , Spampinato Giovanni
Published: January 2023

Human activities and climate change are the main factors causing habitat loss, jeopardising the survival of many species, especially those with limited range, such as endemic species. Recently, species distribution models (SDMs) have been used in conservation biology to assess their extinction risk, environmental dynamics, and potential distribution. This study analyses the potential, current and future distribution range of Salvia ceratophylloides Ard., an endemic perennial species of the Lamiaceae family that occurs exclusively in a limited suburban area of the city of Reggio Calabria (southern Italy). The MaxEnt model was employed to configure the current potential range of the species using bioclimatic and edaphic variables, and to predict the potential suitability of the habitat in relation to two future scenarios (SSP245 and SSP585) for the periods 2021–2040 and 2041–2060. The field survey, which spanned 5 years (2017–2021), involved 17 occurrence points. According to the results of the MaxEnt model, the current potential distribution is 237.321 km2, which considering the preferred substrates of the species and land-use constraints is re-estimated to 41.392 km2. The model obtained from the SSP245 future scenario shows a decrease in the area suitable for the species of 35% in the 2021–2040 period and 28% in the 2041–2060 period. The SSP585 scenario shows an increase in the range suitable for hosting the species of 167% in the 2021–2040 period and 171% in the 2041–2060 period. Assessing variation in the species distribution related to the impacts of climate change makes it possible to define priority areas for reintroduction and in situ conservation. Identifying areas presumably at risk or, on the contrary, suitable for hosting the species is of paramount importance for management and conservation plans for Salvia ceratophylloides.
Outcome of Continuous Positive Airway Pressure Adherence Based on Nasal Endoscopy and the Measurement of Nasal Patency—A Prospective Study
Authors: Knížek Zdeněk , Kotulek Miloš , Brothánková Pavlína , Pecháčková Eva , Klail Pavel , Kostlivý Tomáš , Vodička Jan
Published: January 2023

The gold standard for treating obstructive sleep apnea in adults is continuous positive airway pressure (CPAP). However, it can be difficult to convince patients to adhere to this therapy. The aim of this study was to determine the relationship between nasal endoscopy findings/nose patency and CPAP adherence. Material and methods: A cohort of 450 consecutive patients suspected of having OSA were prospectively enrolled. For further analyses, 47 OSA patients undergoing CPAP treatment were selected (13 females and 34 males, average age, 65.3 years, BMI 34.1, apnea-hypopnea index. AHI 51.0). The patients were divided into two groups: patients with good CPAP adherence (n = 35) and patients who did not adhere to CPAP therapy (n = 12). The influence of nasal endoscopy and flow measurement on CPAP adherence was explored. Results: We found a statistical independence between adherence to CPAP and AHI (p = 0.124), T90 (p = 0.502), endoscopic findings (p = 0.588) and nasal patency measured by a flowmeter (p = 0.498). Conclusions: In our studied sample, endoscopic findings and nasal patency measured by a flowmeter were not predictors of CPAP non-adherence in the first year of the treatment. Our data show that while an endoscopic finding in the nasal cavity could indicate that a patient has a severe obstruction, compliance with CPAP therapy is not reduced in these patients and neither is it reduced with a decrease in nasal flow, according to our observation.
Involvement of an Aberrant Vascular System in Neurodevelopmental, Neuropsychiatric, and Neuro-Degenerative Diseases
Authors: Ishihara Keiichi , Takata Kazuyuki , Mizutani Ken-ichi
Published: January 2023

The vascular system of the prenatal brain is crucial for the development of the central nervous system. Communication between vessels and neural cells is bidirectional, and dysfunctional communication can lead to neurodevelopmental diseases. In the present review, we introduce neurodevelopmental and neuropsychiatric diseases potentially caused by disturbances in the neurovascular system and discuss candidate genes responsible for neurovascular system impairments. In contrast to diseases that can manifest during the developing stage, we have also summarized the disturbances of the neurovascular system in neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. Furthermore, we discussed the role of abnormal vascularization and dysfunctional vessels in the development of neurovascular-related diseases.
Seroprevalence Trends and Molecular Epidemiology of Viral Hepatitis in Croatia
Authors: Vilibic-Cavlek Tatjana , Zidovec-Lepej Snjezana , Ferenc Thomas , Savic Vladimir , Nemeth-Blazic Tatjana , Vujica Ferenc Mateja , Bogdanic Maja , Vilibic Maja , Simunov Bojana , Janev-Holcer Natasa , Jelicic Pavle , Ljubas Dominik , Kosar Tian , Ilic Maja , Kucinar Jasmina , Barbic Ljubo , Stevanovic Vladimir , Mrzljak Anna
Published: January 2023

Viral hepatitis is a significant cause of morbidity and mortality worldwide. In Croatia, hepatitis B virus (HBV) and hepatitis C virus (HCV) are widely distributed, especially in some high-risk groups such as people who inject drugs (PWID), prisoners, and highly promiscuous groups. The seroprevalence of HBV ranges from 7.0% in the general population to 38.8% in PWID, depending on the region. The seroprevalence of HCV is highest among PWID (29–75.5%) as compared to 0.9% in the general population. Analyzing the distribution of HCV genotypes, no substantial changes in the molecular epidemiology of the two most frequent HCV genotypes (1 and 3) in the past 20 years were observed. However, the predominance of subtype 1b compared to subtype 1a as detected in 1996–2005 was not confirmed in 2008–2015. Hepatitis A virus (HAV) incidence was high in the past with a decreasing trend since the 2000s, except for an outbreak in 2017–2018 as part of the large European outbreak, which was mainly among men who have sex with men. Hepatitis E virus (HEV) is an emerging virus detected for the first time in Croatia in 2012. The seroprevalence of HEV is high among hemodialysis patients (27.9%) and liver transplant recipients (19.3–24.4%). In addition, higher seroprevalence rates were observed in animal-related professions (e.g., veterinarians, 15.2%; hunters, 14.9%). All detected HEV strains belonged to genotype 3.
Targeting Neuroinflammation to Alleviate Chronic Olfactory Dysfunction in Long COVID: A Role for Investigating Disease-Modifying Therapy (DMT)?
Authors: Di Stadio Arianna , Bernitsas Evanthia , La Mantia Ignazio , Brenner Michael J. , Ralli Massimo , Vaira Luigi Angelo , Colizza Andrea , Cavaliere Carlo , Laudani Matteo , Frohman Teresa C. , De Vincentiis Marco , Frohman Elliot M. , Altieri Marta
Published: January 2023

Chronic olfactory dysfunction after SARS-CoV-2 infection occurs in approximately 10% of patients with COVID-19-induced anosmia, and it is a growing public health concern. A regimen of olfactory training and anti-neuroinflammatory therapy with co-ultramicronized palmitoylethanolamide with luteolin (um-PEA-LUT) has shown promising results in clinical trials; however, approximately 15% of treated patients do not achieve full recovery of a normal olfactory threshold, and almost 5% have no recovery. Disease-modifying therapies (DMTs), which are used to treat autoimmune neuroinflammation in multiple sclerosis (MS), have not been studied for treating persistent inflammation in refractory post-COVID-19 smell disorder. This study evaluated COVID-19-related smell loss and MS-related smell loss, comparing the responses to different therapies. Forty patients with MS and 45 reporting post-COVID-19 olfactory disorders were included in the study. All patients underwent nasal endoscopy and were evaluated by using validated Sniffin’ Sticks testing. The patients with long COVID were treated for three months with um-PEA-LUT plus olfactory training. The patients with MS were treated with DMTs. Olfactory functions before and after treatment were analyzed in both groups. At the experimental endpoint, 13 patients in the COVID-19 group treated with um-PEA-LUT had residual olfactory impairment versus 10 patients in the MS group treated with DMTs. The severity of the persistent olfactory loss was lower in the MS group, and the patients with MS treated with IFN-beta and glatiramer acetate had the preservation of olfactory function. These data provide a rationale for considering prospective trials investigating the efficacy of DMTs for post-COVID-19 olfactory disorders that are refractory to um-PEA-LUT with olfactory training. This study is the first to consider the role of DMT in treating refractory post-viral olfactory loss in patients with long COVID.
Distribution of Embryonic Stem Cell-Derived Mesenchymal Stem Cells after Intravenous Infusion in Hypoxic–Ischemic Encephalopathy
Authors: Lee Su Hyun , Choung Jin Seung , Kim Jong Moon , Kim Hyunjin , Kim MinYoung
Published: January 2023

Systemic administration of mesenchymal stem cells (MSCs) has been reported to improve neurological function in brain damage, including hypoxic–ischemic encephalopathy (HIE), though the action mechanisms have not been fully elucidated. In this study, the cells were tracked live using a Pearl Trilogy Small Animal fluorescence imaging system after human embryonic stem Cell-Derived MSCs (ES-MSCs) infusion for an HIE mouse model. ES-MSC–treated HIE mice showed neurobehavioral improvement. In vivo imaging showed similar sequential migration of ES-MSCs from lungs, liver, and spleen within 7 days in both HIE and normal mice with the exception of lungs, where there was higher entrapment in the HIE 1 h after infusion. In addition, ex vivo experiments confirmed time-dependent infiltration of ES-MSCs into the organs, with similar findings in vivo, although lungs and brain revealed small differences. ES-MSCs seemed to remain in the brain only in the case of HIE on day 14 after the cell infusion. The homing effect in the host brain was confirmed with immunofluorescence staining, which showed that grafted cells remained in the brain tissue at the lesion area with neurorestorative findings. Further research should be carried out to elucidate the role of each host organ’s therapeutic effects when stem cells are systemically introduced.
Acknowledgment to the Reviewers of Logistics in 2022
Authors:   Logistics Editorial Office
Published: January 2023

High-quality academic publishing is built on rigorous peer review [...]
True Stress Theory of Matrix in A Composite: A Topical Review
Authors: Huang Zheng-Ming
Published: January 2023

Whereas mechanics theories for isotropic materials are almost matured, only linear elastic theories for composites were essentially established. This is because only homogenized or approximated stresses are obtainable for a composite. Its mechanical properties must be estimated on a true stress level. According to Eshelby, the true stresses of the fiber are the same as its homogenized counterparts. The true stress theory for the matrix was systematically established by the author, and is reviewed and summarized in the paper. An Excel table-based program for calculating all of the possible true stress components is provided as a supplement for the reader to download. As most composite failures are caused by matrix failures, the true stress theory plays a predominant role in estimating the composite properties outside a linear elastic range. Some challenging composite failures were resolved upon the matrix true stresses, and are highlighted in the paper.
Duplex Coating Combing Vanadate-Intercalated Layered Double Hydroxide and Ce-Doped Sol–Gel Layers on Aluminum Alloy for Active Corrosion Protection
Authors: Wei Kai , Zhao Xuejie , Zhang Zhe , Yuan Yujie , Kong Wenquan , Zhang You
Published: January 2023

In this study, a duplex coating system (LDH-V/SG-Ce) of vanadate-intercalated layered double hydroxide (LDH) and Ce-doped sol–gel (SG) layers was developed for the purpose of active corrosion protection of the aluminum alloy AA2024. ZnAl-LDH film was grown in situ on the surface of an aluminum alloy using a hydrothermal method and intercalated with V2O74− anions as corrosion inhibitors, and sealed with a Ce (III)-doped silane coating using a sol–gel technique. Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and X-ray diffraction (XRD) analyses were used to analyze the microstructure, surface functional groups and structure of the LDH-V/SG-Ce film. The uniform and compact silane layer was covered both in the pores and on top of the LDH film. The results of glow discharge optical emission spectroscopy (GDOES) indicated that V2O74− and Ce (III) ions were loaded in the LDH layer and silane film, respectively. The potentiodynamic polarization results showed that the corrosion current density of the bilayer system in the presence of corrosion inhibitors was reduced to 1.92 × 10−8 A/cm2. Electrochemical impedance spectroscopy (EIS) results showed that the LDH-V/SG-Ce duplex coating could provide effective protection for the aluminum alloy after being exposed to a corrosive solution for 14 days.
Hot Workability of the Multi-Size SiC Particle-Reinforced 6013 Aluminum Matrix Composites
Authors: Wu Changlong , Chen Shuang , Tang Jie , Fu Dingfa , Teng Jie , Jiang Fulin
Published: January 2023

The size and distribution of ceramic particles in aluminum matrix composites have been reported to remarkably influence their properties. For a single ceramic particle, the particle size is too small and prone to agglomeration, which makes the mechanical properties of the composites worse. When the ceramic particle size is too large, the particles and alloy at the interface are not firmly bonded, and the effect of dispersion distribution is not achieved, which will also reduce the mechanical properties of the composites. The multi-size ceramic particles are expected to improve this situation, while their effect on hot workability is less studied. In this study, the hot deformation behavior, constitutive model, processing map and SEM microstructure were investigated to evaluate the hot workability of multi-size SiC particle-reinforced 6013 aluminum matrix composites. The results showed that the increased deformation temperature and decreased strain rate could decrease flow stresses. The flow stress behaviors of the composites can be described by the sine-hyperbolic Arrhenius equation with the deformation activation energy of Q = 205.863 kJ/mol. The constitutive equation of the composites is ε ˙=3.11592×1013sinh0.024909σ4.12413exp−205863RT. Then, the hot processing map of the SiCp/6013 composites was constructed and verified by SEM observations. The rheological instability zone was in the region of a high strain rate. The optimal processing zone for composites was 450~500 °C and 0.03~0.25 s−1. In addition, the strain level was found to increase both the Q value and the area of the instability zone.
Path Planning of Unmanned Aerial Vehicle in Complex Environments Based on State-Detection Twin Delayed Deep Deterministic Policy Gradient
Authors: Zhang Danyang , Xuan Zhaolong , Zhang Yang , Yao Jiangyi , Li Xi , Li Xiongwei
Published: January 2023

This paper investigates the path planning problem of an unmanned aerial vehicle (UAV) for completing a raid mission through ultra-low altitude flight in complex environments. The UAV needs to avoid radar detection areas, low-altitude static obstacles, and low-altitude dynamic obstacles during the flight process. Due to the uncertainty of low-altitude dynamic obstacle movement, this can slow down the convergence of existing algorithm models and also reduce the mission success rate of UAVs. In order to solve this problem, this paper designs a state detection method to encode the environmental state of the UAV’s direction of travel and compress the environmental state space. In considering the continuity of the state space and action space, the SD-TD3 algorithm is proposed in combination with the double-delayed deep deterministic policy gradient algorithm (TD3), which can accelerate the training convergence speed and improve the obstacle avoidance capability of the algorithm model. Further, to address the sparse reward problem of traditional reinforcement learning, a heuristic dynamic reward function is designed to give real-time rewards and guide the UAV to complete the task. The simulation results show that the training results of the SD-TD3 algorithm converge faster than the TD3 algorithm, and the actual results of the converged model are better.
Multi-Frequency Homotopy Analysis Method for Coupled Van der Pol-Duffing System with Time Delay
Authors: Qian Youhua , Wang Shuli , Chen Shuping
Published: January 2023

This paper mainly studied the analytical solutions of three types of Van der Pol-Duffing equations. For a system with parametric excitation frequency, we knew that the ordinary homotopy analysis method would be unable to find the analytical solution. Thus, we primarily used the multi-frequency homotopy analysis method (MFHAM). First, the MFHAM was introduced, and the solution of the system was expressed by constructing auxiliary linear operators. Then, the method was applied to three specific systems. We compared the numerical solution obtained using the Runge–Kutta method with the analytical solution to verify the correctness of the latter. Periodic solutions, with and without time delay, were also compared under the same parameters. The results demonstrated that it was both effective and correct to use the MFHAM to find analytical solutions to Van der Pol-Duffing systems, which were classical systems. By comparison, the MFHAM proved to be effective for time delay systems.
Variable Selection and Allocation in Joint Models via Gradient Boosting Techniques
Authors: Griesbach Colin , Mayr Andreas , Bergherr Elisabeth
Published: January 2023

Modeling longitudinal data (e.g., biomarkers) and the risk for events separately leads to a loss of information and bias, even though the underlying processes are related to each other. Hence, the popularity of joint models for longitudinal and time-to-event-data has grown rapidly in the last few decades. However, it is quite a practical challenge to specify which part of a joint model the single covariates should be assigned to as this decision usually has to be made based on background knowledge. In this work, we combined recent developments from the field of gradient boosting for distributional regression in order to construct an allocation routine allowing researchers to automatically assign covariates to the single sub-predictors of a joint model. The procedure provides several well-known advantages of model-based statistical learning tools, as well as a fast-performing allocation mechanism for joint models, which is illustrated via empirical results from a simulation study and a biomedical application.
Multivariate Extension of Raftery Copula
Authors: Saali Tariq , Mesfioui Mhamed , Shabri Ani
Published: January 2023

This paper introduces a multivariate extension of Raftery copula. The proposed copula is exchangeable and expressed in terms of order statistics. Several properties of this copula are established. In particular, the multivariate Kendall’s tau and Spearman’s rho, as well as the density function, of the suggested copula are derived. The lower and upper tail dependence of the proposed copula are also established. The dependence parameter estimator of this new copula is examined based on the maximum likelihood procedure. A simulation study shows a satisfactory performance of the presented estimator. Finally, the proposed copula is successfully applied to a real data set on black cherry trees.
A Complex Insight for Quality of Service Based on Spreading Dynamics and Multilayer Networks in a 6G Scenario
Authors: Scatá Marialisa , La Corte Aurelio
Published: January 2023

Within the 6G vision, the future of mobile communication networks is expected to become more complex, heterogeneous, and characterized by denser deployments with a myriad of users in an ever-more dynamic environment. There is an increasing intent to provide services following the microservice architecture, thus gaining from higher scalability and significant reliability. Microservices introduce novel challenges and the level of granularity impacts performances, due to complex composition patterns. This openness in design demands service requirements be heterogeneous and dynamic. To this end, we propose a framework and a mathematical approach to investigate the complex quality of services. We exploit the temporal multilayer network representation and analysis jointly, with the spreading dynamics of user experience. We study the joint impact of structural heterogeneity and the evolutionary dynamics of the temporal multilayer quality network, composed of networked parameters, and a temporal multilayer social network, populated by a social layered structure of users. We conducted simulations to display our findings on how this modeling approach enables evaluation of otherwise-overlooked information on quality arising from a profound investigation of the structural-complexity and social-dynamics measurements.
Asymptotic Behavior and Oscillation of Third-Order Nonlinear Neutral Differential Equations with Mixed Nonlinearities
Authors: Hassan Taher S. , El-Matary Bassant M.
Published: January 2023

In this paper, we investigate the asymptotic properties of third-order nonlinear neutral differential equations with mixed nonlinearities using the comparison principle. Our results not only vastly improve upon but also broadly generalize many previously known ones. Examples demonstrating the applicability and efficacy of our results are provided.
Random Risk Factors Influencing Cash Flows: Modifying RADR
Authors: Hoshovska Oksana , Poplavska Zhanna , Kajanova Jana , Trevoho Olena
Published: January 2023

In this article, we focus on considering different risk factors influencing the cash flows of a group of companies. A methodology is suggested for approximated consideration of both seasonal and random fluctuations in the environment, which have some impact on the overall group activity and may be considered via modification of the risk-adjusted discount rates. The main steps of the suggested methodology are described, and the elements of the risk-adjusted discount rate are presented. Although it is the general convention to use the market rate as the discount rate in most cases, under certain circumstances—i.e., stochastic shocks related to the level of interest rates, shifts, and turnabouts in the social environment, as well as the market transformations due to annual/seasonal epidemics, the use of a risk-adjusted discount rate becomes essential. The influence of the seasonal and random changes in the general environment on the companies’ activity through modification of the discount rate is illustrated both numerically and graphically in the article, providing analysis of the impact of exogenous parameters on companies’ output, profits, net present value, and discounted payback period for the initial investment.