bluuebunny/crossref_metadata_2025 huggingface dataset:
The effects of differing anticoagulant regimes on blood quality after cell salvage in coronary artery bypass grafting (CABG): a pilot study
Authors: Boer Willem , van Tornout Mathias , Brusseleers Maarten , Strauven Maarten , de Vooght Pieter , Vander Laenen Margot , Hoste Eric , Jorens Philippe G.
Published: April 2023

Background

Cell salvage reduces allogenic blood transfusion requirements in surgery. We present a pilot study exploring the impact of anticoagulant choice, citrate or heparin, on the quality of cell salvaged blood in adults undergoing coronary artery bypass grafting (CABG).

Materials and methods

Elective on pump CABG patients were randomly allocated to citrate or heparin anticoagulation. We measured red blood cell characteristics and inflammation in both the blood collection reservoir and the washed red blood cell concentrate. Postoperatively, the level of biomarkers and the coagulation profile in the peripheral blood as well as the transfusion requirements of allogenic blood products were studied.

Results

Thirty eight patients were included, 19 in the citrate group and 19 in the heparin group. Baseline characteristics were similar. In the washed red blood cell concentrate, Mean Hb (g/dl) and Ht (%) were lower in the citrate group [Hb: 18.1 g/dL (SD 1.3) vs. 21.1 (1.6), p < 0.001; Ht: 59.9% (54.7–60.9) vs. 63.7% (62.3–64.8); p < 0.001]; Mean corpuscular volume (MCV, μm 3) was higher [99.1fL (9.4) vs. 88 (4.2), p < 0.001] and mean corpuscular hemoglobin concentration (MCHC, g/dl) lower in the citrate group [31.9 g/dl (29.6–32.4) vs. 33.6 (33.1–34.0) p < 0.001]. Thrombocyte count (1000/μl) was higher in the citrate group [31.0 (26.0–77.0) vs. 13.0 (10.0–39.0); p = 0.006]. There were no differences in the requirement for allogenic blood products’ transfusion (intraoperatively and postoperatively) or in the coagulation parameters after washed red blood cell concentrate infusion. Higher IL-10 was found in the citrate group in the blood collection reservoir, higher neutrophil-derived myeloperoxidase (MPO) in the heparin group after washed red blood cell concentrate infusion.

Conclusion

Though red blood cells in washed red blood cell concentrate were more swollen and diluted in the citrate group with more residual thrombocytes, published quality guidelines were met in both groups. Our pilot study suggests that differences in inflammatory markers in the blood collection reservoir and after infusion of washed red blood cell concentrate indicate a possible pro-inflammatory effect of heparin compared to citrate. A larger study is warranted to confirm these results and their possible clinical consequences.

Trial registrationClinicalTrials.gov: NCT02674906. Registered 5 February 2016.
The increase in cardiac output induced by a decrease in positive end-expiratory pressure reliably detects volume responsiveness: the PEEP-test study
Authors: Lai Christopher , Shi Rui , Beurton Alexandra , Moretto Francesca , Ayed Soufia , Fage Nicolas , Gavelli Francesco , Pavot Arthur , Dres Martin , Teboul Jean-Louis , Monnet Xavier
Published: April 2023

Background

In patients on mechanical ventilation, positive end-expiratory pressure (PEEP) can decrease cardiac output through a decrease in cardiac preload and/or an increase in right ventricular afterload. Increase in central blood volume by fluid administration or passive leg raising (PLR) may reverse these phenomena through an increase in cardiac preload and/or a reopening of closed lung microvessels. We hypothesized that a transient decrease in PEEP (PEEP-test) may be used as a test to detect volume responsiveness.

Methods

Mechanically ventilated patients with PEEP ≥ 10 cmH2O (“high level”) and without spontaneous breathing were prospectively included. Volume responsiveness was assessed by a positive PLR-test, defined as an increase in pulse-contour-derived cardiac index (CI) during PLR ≥ 10%. The PEEP-test consisted in reducing PEEP from the high level to 5 cmH2O for one minute. Pulse-contour-derived CI (PiCCO2) was monitored during PLR and the PEEP-test.

Results

We enrolled 64 patients among whom 31 were volume responsive. The median increase in CI during PLR was 14% (11–16%). The median PEEP at baseline was 12 (10–15) cmH2O and the PEEP-test resulted in a median decrease in PEEP of 7 (5–10) cmH2O, without difference between volume responsive and unresponsive patients. Among volume responsive patients, the PEEP-test induced a significant increase in CI of 16% (12–20%) (from 2.4 ± 0.7 to 2.9 ± 0.9 L/min/m2, p < 0.0001) in comparison with volume unresponsive patients. In volume unresponsive patients, PLR and the PEEP-test increased CI by 2% (1–5%) and 6% (3–8%), respectively. Volume responsiveness was predicted by an increase in CI > 8.6% during the PEEP-test with a sensitivity of 96.8% (95% confidence interval (95%CI): 83.3–99.9%) and a specificity of 84.9% (95%CI 68.1–94.9%). The area under the receiver operating characteristic curve of the PEEP-test for detecting volume responsiveness was 0.94 (95%CI 0.85–0.98) (p < 0.0001 vs. 0.5). Spearman’s correlation coefficient between the changes in CI induced by PLR and the PEEP-test was 0.76 (95%CI 0.63–0.85, p < 0.0001).

Conclusions

A CI increase > 8.6% during a PEEP-test, which consists in reducing PEEP to 5 cmH2O, reliably detects volume responsiveness in mechanically ventilated patients with a PEEP ≥ 10 cmH2O.

Trial registration ClinicalTrial.gov (NCT 04,023,786). Registered July 18, 2019. Ethics Committee approval CPP Est III (N° 2018-A01599-46).
Development of insecticide-impregnated polyester/cotton blend fabric and assessment of their repellent characteristics against Cimex lectularius and dengue vectors Aedes albopictus and Aedes aegypti
Authors: Kakati Ajay , Banerjee Amartya , Das Parikshit , Saha Buddhadeb , Goyary Danswrang , Karmakar Sanjeev , Kishor Sumit , Bhutia Yangchen D. , Chattopadhyay Pronobesh
Published: April 2023

Background

Personal protection measures using insecticide-treated fabric is one of the most effective strategies to prevent the bites of hematophagous insects. Many countries have had success treating fabrics with pyrethroids on an individual level.

Methods

In the current study, a new combination of insecticides, alpha-cypermethrin (ACP) and deltamethrin (DET), has been impregnated on fabric composed of a 50:50 blend of polyester and cotton. Residual and morphological analysis was performed along with the evaluation of physical parameters. Biological evaluations were performed to check the repellency, knockdown, and mortality of insecticide-impregnated fabric (IIF) against bed bugs (Cimex lectularius)using Petri plate assay and mosquitoes (Aedes aegyptiandAedes albopictus)using cone bioassay.

Results

The results showed the repellency of IIF to be 56.6% forC. lectulariusand a knockdown percentage of 53.3% and 63.3% forAe. aegyptiandAe. albopictus, respectively. A > 80% mortality was found for both species of mosquitoes up to 20 cycles of washing with no significant difference (P > 0.05). From high-performance liquid chromatography (HPLC) analysis, the reduction in the contents of ACP and DET after subsequent washes can be correlated with the overall decrease in bioefficacy. ACP and DET remaining in unit gram of fabric after 20 wash cycles were found to be 5.4 mg and 3.1 mg, respectively. By examining the fabric’s surface morphology using scanning electron microscope (SEM) and utilizing energy-dispersive x-ray (EDX) analysis, it was possible to identify the presence of insecticides that were adhered to the fabric. Differential scanning calorimetry (DSC) showed distinctive endothermic peak of insecticide at 98.3 ºC, whereas no change in thermal behavior was observed from thermo-gravimetric analysis (TGA). Furthermore, the physical attributes of IIF provide conclusive evidence for its firmness.

Conclusion

All experimental findings were consistent with the potential use of IIF as a bed bug- and mosquito-repellent fabric to be used against hematophagous infestations. This fabric can serve as a potential strategy to control vector-borne diseases like dengue, malaria, trench fever, etc.

Graphical Abstract
Effects of foot intensive rehabilitation (FIRE) on clinical outcomes for patients with chronic ankle instability: a randomized controlled trial protocol
Authors: Hoch Matthew C. , Hertel Jay , Gribble Phillip A. , Heebner Nicholas R. , Hoch Johanna M. , Kosik Kyle B. , Long Doug , Sessoms Pinata H. , Silder Amy , Torp Danielle M. , Thompson Katherine L. , Fraser John J.
Published: April 2023

Background

Lateral ankle sprains account for a large proportion of musculoskeletal injuries among civilians and military service members, with up to 40% of patients developing chronic ankle instability (CAI). Although foot function is compromised in patients with CAI, these impairments are not routinely addressed by current standard of care (SOC) rehabilitation protocols, potentially limiting their effectiveness. The purpose of this randomized controlled trial is to determine if a Foot Intensive REhabilitation (FIRE) protocol is more effective compared to SOC rehabilitation for patients with CAI.

Methods

This study will use a three-site, single-blind, randomized controlled trial design with data collected over four data collection points (baseline and post-intervention with 6-, 12-, and 24-month follow-ups) to assess variables related to recurrent injury, sensorimotor function, and self-reported function. A total of 150 CAI patients (50 per site) will be randomly assigned to one of two rehabilitation groups (FIRE or SOC). Rehabilitation will consist of a 6-week intervention composed of supervised and home exercises. Patients assigned to SOC will complete exercises focused on ankle strengthening, balance training, and range of motion, while patients assigned to FIRE will complete a modified SOC program along with additional exercises focused on intrinsic foot muscle activation, dynamic foot stability, and plantar cutaneous stimulation.

Discussion

The overall goal of this trial is to compare the effectiveness of a FIRE program versus a SOC program on near- and long-term functional outcomes in patients with CAI. We hypothesize the FIRE program will reduce the occurrence of future ankle sprains and ankle giving way episodes while creating clinically relevant improvements in sensorimotor function and self-reported disability beyond the SOC program alone. This study will also provide longitudinal outcome findings for both FIRE and SOC for up to two years. Enhancing the current SOC for CAI will improve the ability of rehabilitation to reduce subsequent ankle injuries, diminish CAI-related impairments, and improve patient-oriented measures of health, which are critical for the immediate and long-term health of civilians and service members with this condition.

Trial Registration Clinicaltrials.gov Registry: NCT #NCT04493645 (7/29/20).
Relations in the context of Turiyam sets
Authors: Ganati Gamachu Adugna , Srinivasa Rao Repalle V. N. , Ashebo Mamo Abebe
Published: April 2023

Objective

Recently, the Turiyam set was introduced as an extension of the neutrosophic set to handle the uncertainty data set beyond its truth, indeterminacy and falsity values. This article introduced the Cartesian product of Turiyam sets and Turiyam relations. Further, we defined operations on Turiyam relations as well as discussed the inverse and types of Turiyam relations.

Results

The Cartesian product of Turiyam sets, Turiyam relations, inverse Turiyam relation and types of Turiyam relations are stated and their properties are derived. Furthermore, examples are given to clarify some concepts.
Empirical retinal venous pulse wave velocity using modified photoplethysmography
Authors: Abdul-Rahman Anmar , Morgan William , Vukmirovic Aleksandar , Mehnert Andrew , Obreschow Danail , Yu Dao-Yi
Published: April 2023

Objective

Using the novel imaging method of high-speed modified photoplethysmography we measured the retinal venous pulse wave velocity in a single case.

Results

A healthy 30-year-old subject underwent high-speed modified photoplethysmography (120 frames per second) with simultaneous ophthalmodynamometry at 26 Meditron units. A video of the optic nerve was analyzed using custom software. A harmonic regression model was fitted to each pixel in the time series and used to quantify the retinal vascular pulse wave parameters. Retinal venous pulsation at the optic disc was observed as a complex dynamic wall motion, whereas contraction commenced at a point in the vein at the center of the optic disc, and progressed centrifugally. The empirically estimated retinal venous pulse wave velocity at this segment was approximately 22.24694 mm/s. This measurement provides an estimate for future studies in the field.
MolFilterGAN: a progressively augmented generative adversarial network for triaging AI-designed molecules
Authors: Liu Xiaohong , Zhang Wei , Tong Xiaochu , Zhong Feisheng , Li Zhaojun , Xiong Zhaoping , Xiong Jiacheng , Wu Xiaolong , Fu Zunyun , Tan Xiaoqin , Liu Zhiguo , Zhang Sulin , Jiang Hualiang , Li Xutong , Zheng Mingyue
Published: April 2023

Artificial intelligence (AI)-based molecular design methods, especially deep generative models for generating novel molecule structures, have gratified our imagination to explore unknown chemical space without relying on brute-force exploration. However, whether designed by AI or human experts, the molecules need to be accessibly synthesized and biologically evaluated, and the trial-and-error process remains a resources-intensive endeavor. Therefore, AI-based drug design methods face a major challenge of how to prioritize the molecular structures with potential for subsequent drug development. This study indicates that common filtering approaches based on traditional screening metrics fail to differentiate AI-designed molecules. To address this issue, we propose a novel molecular filtering method, MolFilterGAN, based on a progressively augmented generative adversarial network. Comparative analysis shows that MolFilterGAN outperforms conventional screening approaches based on drug-likeness or synthetic ability metrics. Retrospective analysis of AI-designed discoidin domain receptor 1 (DDR1) inhibitors shows that MolFilterGAN significantly increases the efficiency of molecular triaging. Further evaluation of MolFilterGAN on eight external ligand sets suggests that MolFilterGAN is useful in triaging or enriching bioactive compounds across a wide range of target types. These results highlighted the importance of MolFilterGAN in evaluating molecules integrally and further accelerating molecular discovery especially combined with advanced AI generative models.
Effects of high-grain diet feeding on fatty acid profiles in milk, blood, muscle, and adipose tissue, and transcriptional expression of lipid-related genes in muscle and adipose tissue of dairy cows
Authors: Cui Qiaorong , Lin Limei , Lai Zheng , Mao Shengyong
Published: April 2023

Background

High-grain (HG) diets affect lipid metabolism in the liver and mammary tissue of dairy cows, but its effects on muscle and adipose tissue have not been wide evaluated. Thus, the aim of this study is to clarify this issue.

Methods

Twelve Holstein cows were randomly divided into two groups: conventional diet group (CON,n = 6) and the HG diet group (n = 6). On day 7 of week 4, rumen fluid was sampled to measure pH, milk was sampled to measure components, and blood was sampled to measure biochemical parameters and fatty acid composition. After the experiment, cows were slaughtered to collect muscle and adipose tissue for fatty acid composition and transcriptome analysis.

Results

HG feeding decreased the ruminal pH, milk’s fat content and long-chain fatty acid proportion (P < 0.05) and increased the proportion of short- and medium-chain fatty acids in the milk (P < 0.05) as compared with CON diets. The concentrations of blood cholesterol, low-density lipoprotein, and polyunsaturated fatty acids in the HG cows were lower than those in CON cows (P < 0.05). In muscle tissue, HG feeding tended to increase the triacylglycerol (TG) concentration (P < 0.10). Transcriptome analysis revealed changes in the biosynthesis of the unsaturated fatty acids pathway, the regulation of lipolysis in the adipocytes pathway, and the PPAR signalling pathway. In adipose tissue, HG feeding increased the concentration of TG and decreased the concentration of C18:1cis9 (P < 0.05). At the transcriptome level, the fatty acid biosynthesis pathway, linoleic acid metabolism pathway, and PPAR signalling pathway were activated.

Conclusion

HG feeding leads to subacute rumen acidosis and a decreased milk fat content. The fatty acid profiles in the milk and plasma of dairy cows were changed by HG feeding. In muscle and adipose tissue, HG feeding increased TG concentration and up-regulated the expression of genes related to adipogenesis, while down-regulated the expression of genes related to lipid transport. These results complement our knowledge of the fatty acid composition of muscle and adipose tissue in dairy cows and expand our understanding of the mechanisms by which HG diets affect lipid metabolism in muscle and adipose tissue.
Colonization and development of the gut microbiome in calves
Authors: Du Yufeng , Gao Ya , Hu Mingyang , Hou Jinxiu , Yang Linhai , Wang Xianghuang , Du Wenjuan , Liu Jianxin , Xu Qingbiao
Published: April 2023

Colonization and development of the gut microbiome are crucial for the growth and health of calves. In this review, we summarized the colonization, beneficial nutrition, immune function of gut microbiota, function of the gut barrier, and the evolution of core microbiota in the gut of calves of different ages. Homeostasis of gut microbiome is beneficial for nutritional and immune system development of calves. Disruption of the gut microbiome leads to digestive diseases in calves, such as diarrhea and intestinal inflammation. Microbiota already exists in the gut of calf fetuses, and the colonization of microbiota continues to change dynamically under the influence of various factors, which include probiotics, diet, age, and genotype. Colonization depends on the interaction between the gut microbiota and the immune system of calves. The abundance and diversity of these commensal microbiota stabilize and play a critical role in the health of calves.
Efficiency determination of J-PET: first plastic scintillators-based PET scanner
Authors: Sharma S. , Baran J. , Chug N. , Curceanu C. , Czerwiński E. , Dadgar M. , Dulski K. , Eliyan K. , Gajos A. , Gupta-Sharma N. , Hiesmayr B. C. , Kacprzak K. , Kapłon Ł. , Klimaszewski K. , Konieczka P. , Korcyl G. , Kozik T. , Krzemień W. , Kumar D. , Niedźwiecki Sz. , Panek D. , Parzych S. , del Rio E. Perez , Raczyński L. , Choudhary Shivani , Shopa R. Y. , Skurzok M. , Stępień E. Ł. , Tayefi F. , Tayefi K. , Wiślicki W. , Moskal P.
Published: April 2023

Background

The Jagiellonian Positron Emission Tomograph is the 3-layer prototype of the first scanner based on plastic scintillators, consisting of 192 half-metre-long strips with readouts at both ends. Compared to crystal-based detectors, plastic scintillators are several times cheaper and could be considered as a more economical alternative to crystal scintillators in future PETs. JPET is also a first multi-photon PET prototype. For the development of multi-photon detection, with photon characterized by the continuous energy spectrum, it is important to estimate the efficiency of J-PET as a function of energy deposition. The aim of this work is to determine the registration efficiency of the J-PET tomograph as a function of energy deposition by incident photons and the intrinsic efficiency of the J-PET scanner in detecting photons of different incident energies. In this study, 3-hit events are investigated, where 2-hits are caused by 511 keV photons emitted in $$e^+e^-$$

e
+

e
-

annihilations, while the third hit is caused by one of the scattered photons. The scattered photon is used to accurately measure the scattering angle and thus the energy deposition. Two hits by a primary and a scattered photon are sufficient to calculate the scattering angle of a photon, while the third hit ensures the precise labeling of the 511 keV photons.

Results

By comparing experimental and simulated energy distribution spectra, the registration efficiency of the J-PET scanner was determined in the energy deposition range of 70–270 keV, where it varies between 20 and 100$$\%$$
%
. In addition, the intrinsic efficiency of the J-PET was also determined as a function of the energy of the incident photons.

Conclusion

A method for determining registration efficiency as a function of energy deposition and intrinsic efficiency as a function of incident photon energy of the J-PET scanner was demonstrated. This study is crucial for evaluating the performance of the scanner based on plastic scintillators and its applications as a standard and multi-photon PET systems. The method may be also used in the calibration of Compton-cameras developed for the ion−beam therapy monitoring and simultaneous multi-radionuclide imaging in nuclear medicine.
Validation of $$^{99m}$$Tc and $$^{177}$$Lu quantification parameters for a Monte Carlo modelled gamma camera
Authors: Di Domenico Giovanni , Di Biaso Simona , Longo Lorenzo , Turra Alessandro , Tonini Eugenia , Longo MariaConcetta , Uccelli Licia , Bartolomei Mirco
Published: April 2023

Purpose

Monte Carlo (MC) simulation in Nuclear Medicine is a powerful tool for modeling many physical phenomena which are difficult to track or measure directly. MC simulation in SPECT/CT imaging is particularly suitable for optimizing the quantification of activity in a patient, and, consequently, the absorbed dose to each organ. To do so, validating MC results with real data acquired with gamma camera is mandatory. The aim of this study was the validation of the calibration factor (CF) and the recovery coefficient (RC) obtained with SIMIND Monte Carlo code for modeling a Siemens Symbia Intevo Excel SPECT-CT gamma camera to ensure optimal $$^{99m}$$

99
m

Tc and $$^{177}$$

177

Lu SPECT quantification.

Methods

Phantom experiments using $$^{99m}$$

99
m

Tc and $$^{177}$$

177

Lu have been performed to measure spatial resolution and sensitivity, as well as to evaluate the CF and RC from acquired data. The geometries used for 2D planar imaging were (1) Petri dish and (2) capillary source while for 3D volumetric imaging were (3) a uniform filled cylinder phantom and (4) a Jaszczack phantom with spheres of different volumes. The experimental results have been compared with the results obtained from Monte Carlo simulations performed in the same geometries.

Results

Comparison shows good accordance between simulated and experimental data. The measured planar spatial resolution was 8.3$$\pm 0.8$$

±
0.8

 mm for $$^{99m}$$

99
m

Tc and 11.8±0.6 mm for $$^{177}$$

177

Lu. The corresponding data obtained by SIMIND for $$^{99m}$$

99
m

Tc was 7.8±0.1 mm, while for $$^{177}$$

177

Lu was 12.4±0.4 mm. The CF was 110.1±5.5 cps/MBq for Technetium and 18.3±1.0 cps/MBq for Lutetium. The corresponding CF obtained by SIMIND for $$^{99m}$$

99
m

Tc was 107.3±0.3 cps/MBq, while for $$^{177}$$

177

Lu 20.4±0.7 cps/MBq. Moreover, a complete curve RCs vs Volume (ml) both for Technetium and Lutetium was determined to correct the PVE for all volumes of clinical interest. In none of the cases, a RC coefficient equal to 100 was found.

Conclusions

The validation of quantification parameters shows that SIMIND can be used for simulating both gamma camera planar and SPECT images of Siemens Symbia Intevo using $$^{99m}$$

99
m

Tc and $$^{177}$$

177

Lu radionuclides for different medical purposes and treatments.
The effect of mothers’ nutritional education and knowledge on children’s nutritional status: a systematic review
Authors: Prasetyo Yoyok Bekti , Permatasari Pipit , Susanti Henny Dwi
Published: April 2023

Malnutrition in children is a significant risk factor for child mortality and is a global health problem. One of the influencing factors is low economic factors and the mother's education. This study aimed to analyze the effect of mothers’ nutritional education and knowledge on children’s nutritional status: a systematic review. The literature examined in this literature review uses four databases, including Embase, ProQuest, PubMed, and Google scholar. The studies included the effect of nutrition education on maternal knowledge and children's nutritional status. Nutrition education impacted mothers’ knowledge, attitudes, and skills (p < 0.001). The effect of nutrition education on mothers affects children’s nutritional status, namely in the form of changes in the average birth weight of children, increasing 0.257 kg/0.26 kg compared with birth weight in the control group (β = 0.257, p < 0.001). Nutrition education has a significant impact on increasing maternal knowledge and children's nutritional status. Sharing various approaches can be done by providing nutrition education, brainstorming, and demonstrations. Nutritional health education methods and media can be in booklets, guidebooks, leaflets, and internet technology applications.
Rhabdomyolysis caused by interaction between rosuvastatin and vadadustat: a case report
Authors: Sakurama Keiki , Iguchi Yuki , Haruki Sara , Hata Yusuke , Hiraga Madoka , Yumoto Shinya , Kai Yutaka
Published: April 2023

Background

Rhabdomyolysis is a potentially life-threatening disease caused by melting or necrosis of skeletal muscle cells and leakage of muscle components into the bloodstream. It has been reported that the interaction of the HMG-CoA reductase inhibitor rosuvastatin with the renal anemia drug vadadustat increases the blood concentration of rosuvastatin in vitro. In this study, we report a case of suspected rhabdomyolysis caused by the drug interaction of rosuvastatin and vadadustat in clinical practice.

Case presentation

A 62-year-old male with medical records of hypertension, myocardial infarction, chronic renal failure, renal anemia, dyslipidemia, and alcoholic liver disease. The patient had been diagnosed with chronic kidney disease (CKD) at the Department of Nephrology, and treated by outpatient care with renal support therapy for the past two years. On X-63 day, his prescription was rosuvastatin (10 mg/day) and a continuous erythrocyte-stimulating agent, epoetin beta pegol (genetical recombination, 100 μg). X-Day 0, blood tests revealed creatine phosphokinase (CPK) 298 U/L, serum creatinine (SCr) 5.26 mg/dL, and hemoglobin (Hb) 9.5 g/dL; thus, the prescription was changed from epoetin beta pegol 100 μg to vadadustat 300 mg/day. On X + day 80, a prescription for a diuretic (azosemide 15 mg/day) was added for swelling of the lower extremities. On X + day 105, we found CPK 16,509 U/L, SCr 6.51 mg/dL, and Hb 9.5 g/dL. The patient was diagnosed as rhabdomyolysis and hospitalized. After hospitalization, rosuvastatin and vadadustat were discontinued and we administered intravenous fluids. Thereafter, CPK and SCr values of the patient improved. On X + day 122, CPK improved to 29 U/L, SCr to 2.6 mg/dL, and Hb to 9.6 g/dL, and he was discharged on X + day 124. At discharge, rosuvastatin 2.5 mg/day was resumed. A blood test on X + day 133 showed CPK 144 U/L and SCr 4.2 mg/dL.

Conclusion

We experienced a case of rhabdomyolysis caused by drug interactions between rosuvastatin and vadadustat.
Thoracoscopic and laparoscopic approach for pleuroperitoneal communication under peritoneal dialysis: a report of four cases
Authors: Hashimoto Teppei , Osaki Toshihiro , Oka Soichi , Fujikawa Takahisa
Published: April 2023

Background

Pleuroperitoneal communication (PPC) is a rare complication of continuous ambulatory peritoneal dialysis (CAPD) and often forces patients to switch to hemodialysis. Some efficiencies of video-assisted thoracic surgery (VATS) for PPC have been reported recently; however, there is no standard approach for these complications. In this case series, we present a combined thoracoscopic and laparoscopic approach for PPC in four patients to better assess its feasibility and efficiency.

Case presentation

Clinical characteristics, perioperative findings, surgical procedures, and clinical outcomes were retrospectively analyzed. We combined VATS with a laparoscopic approach to detect and repair the diaphragmatic lesions responsible for PPC. We first performed pneumoperitoneum in all patients following thoracoscopic exploration. In two cases, we found bubbles gushing out of a small pore in the central tendon of the diaphragm. The lesions were closed with 4-0 non-absorbable monofilament sutures, covered with a sheet of absorbable polyglycolic acid (PGA) felt, and sprayed with fibrin glue. In the other two cases without bubbles, a laparoscope was inserted, and we observed the diaphragm from the abdominal side. In one of the two cases, two pores were detected on the abdominal side. The lesions were closed using sutures and reinforced using the same procedure. In one case, we failed to detect a pore using VATS combined with the laparoscopic approach. Therefore, we covered the diaphragm with only a sheet of PGA felt and fibrin glue. There was no recurrence of PPC, and CAPD was resumed at an average of 11.3 days.

Conclusions

The combined thoracoscopic and laparoscopic approach is an effective treatment for detecting and repairing the lesions responsible for PPC.
Prevention of surgical site infection: a ten-step approach
Authors: Tarabichi Saad , Parvizi Javad
Published: April 2023

Surgical site infection (SSI) is a common cause of morbidity and mortality in patients undergoing surgery. Similarly, periprosthetic joint infection (PJI), is a major cause of failure after total joint arthroplasty (TJA). As the annual volume of TJA procedures is projected to rise, so will the rate of subsequent SSI and PJI. Currently, prevention has been identified as the single most important strategy for combating SSI/PJI. Hence, the present article will serve as a summary of an evidence-based ten-step approach for SSI/PJI prevention that may help orthopedic surgeons with their infection prevention strategies.
Bioactive constituents and health promoting compounds of underutilized fruits of the northern Himalayas of India: a review
Authors: Bachheti Archana , Deepti  , Bachheti Rakesh Kumar , Singh Anjita , Zebeaman Meseret , Hunde Yilma , Husen Azamal
Published: April 2023

Wild and underutilized plants bearing fruits widely grow throughout the northern Himalayas, including Himachal Pradesh, Jammu and Kashmir, Ladakh, and Uttarakhand states of India. The fruits of these plants have the potential for rural development in Northern Himalayas by developing more commercial products.Ficus auriculata,Rubus ellipticus,Myrica esculenta,Ficus palmata,Pyracantha crenulate,Prunus armeniaca,Berberis asiatiica,Pyrus pashia,Rubus niveus,Carissa spinarum,Cordia dichotoma,Flacourtia indica,Malus sikkimensis,Olea ferruginea,Elaeagnus latifolia,Corylus jacquemontii, andPinus gerardianaare some examples of the plant species. Local people mainly consume the fruits of these plant species and a few of them are used for different processed food items such as jam, jelly, juice, squash, and sauce on a small scale. Therefore, fruits of wild and underutilized plants have potential nutritional values. They are widely used as sources of protein, fat, carbohydrate, macronutrients, and micronutrients. These fruits also contain multipurpose and diversified classes of phytochemical compounds such as flavonoids, tannins, terpenoids, saponins, glycosides, and alkaloids, which are applied to treat various human and livestock health ailments. The extracts of underutilized fruits are widely applied to treat cold, fever, fertility disorders, diabetes, and skin diseases. Their phytochemical compounds also demonstrated antipyretic, analgesic, anti-inflammatory, anticancer, antimicrobial, antiplasmodial, and antinociceptive activities. Thus, this review highlights the current research status about the nutritional profiling, chemical composition, and utilization of these valuable fruits effectively/adequately to develop new food and pharmaceutical products.

Graphical Abstract
Effect of health education program on improving knowledge and atitude towards mental health stigma and professional help-seeking among adolescents
Authors: Abd El Salam Amira E. , AbdAllah Amany M. , El Maghawry Hala A.
Published: April 2023

Background

Engaging adolescents in mental health education programs can markedly improve their knowledge, decrease stigma, and enhance professional help-seeking. Two-step study was carried out. The first step was applied to 416 secondary school students in two Egyptian Governorates, using an adapted version of a questionnaire used to survey beliefs and attitudes towards mental illness and professional help-seeking. The second step, a health education program, was implemented upon 224 students; they were classified into intervention and control groups. The program was done to improve their knowledge and attitude.

Results

About 8% of participants had positive findings suggestive of mental illness; the commonest disorder was anxiety disorder (3.9%). Although most of the participants had a positive attitude towards a mentally ill person, 70.7% of them considered mentally ill persons dangerous, and 60.3% will be ashamed if they/their relatives have a mental illness. The main station of seeking help if having a mental trouble was friends (38.9%). The intervention succeeded to change the belief that mental illness is like any other illness from 46.4 to 96.4%. It decreased the belief that mental illness is an evil spirit from 38.4 to 6.3%. Attitude was improved after intervention for all items except in the point of marrying a person with mental illness. Help-seeking from family members or healthcare workers was significantly improved after the intervention.

Conclusions

Anxiety was the commonest mental disorder among the studied group. Negative attitude and wrong beliefs can be changed with health education. Low professional help-seeking may arise the need for more effective professional interventions.
Lead halide perovskite sensitized WSe2 photodiodes with ultrahigh open circuit voltages
Authors: Lee Sung-Joon , Cheng Hung-Chieh , Wang Yiliu , Zhou Boxuan , Li Dehui , Wang Gongming , Liu Yuan , Guo Jian , Wu Hao , Kang Dae Joon , Huang Yu , Duan Xiangfeng
Published: April 2023

Two-dimensional semiconductors (2DSCs) have attracted considerable interests for optoelectronic devices, but are often plagued by the difficulties in tailoring the charge doping type and poor optical absorption due to their atomically thin geometry. Herein, we report a methylammonium lead iodide perovskite (CH3NH3PbI3)/2DSC heterojunction device, in which the electric-field controllable ion migration in the perovskite layer is exploited to induce reversible electron- and hole-doping effects in the underlying monolayer tungsten diselenide (WSe2) to form a programmable p–n photodiode. At the same time, the CH3NH3PbI3 layer functions as a highly efficient sensitization layer to greatly boost the optical absorption and external quantum efficiency (EQE) of the resulting photodiode. By asymmetrically poling the perovskite layer, gold-contacted CH3NH3PbI3/WSe2 devices show a switchable open circuit voltage up to 0.78 V, along with a high EQE of 84.3%. The integration of tunable graphene-contacts further improves the photodiode performance to achieve a highest open circuit voltage of 1.08 V and a maximum EQE of 91.3%, greatly exceeding those achieved previously in 2DSC lateral diodes. Our studies establish a non-invasive approach to switch optoelectronic functions and open up a new avenue toward high-performance reconfigurable optoelectronic devices from 2DSCs.
Saturated Fatty Acids and Omega-3 Polyunsaturated Fatty Acids Improve Metabolic Parameters in Ovariectomized Female Mice
Authors: Sui Ke , Yasrebi Ali , Malonza Natasha , Jaffri Zehra H , Fisher Samuel E , Seelenfreund Isaac , McGuire Brandon D , Martinez Savannah A , MacDonell Avery T , Tveter Kevin M , Longoria Candace R , Shapses Sue A , Campbell Sara C , Roopchand Diana E , Roepke Troy A
Published: April 2023

In menopausal and postmenopausal women, the risk for obesity, cardiovascular disease, osteoporosis, and gut dysbiosis are elevated by the depletion of 17β-estradiol. A diet that is high in omega-6 polyunsaturated fatty acids (PUFAs), particularly linoleic acid (LA), and low in saturated fatty acids (SFAs) found in coconut oil and omega-3 PUFAs may worsen symptoms of estrogen deficiency. To investigate this hypothesis, ovariectomized C57BL/6J and transgenic fat-1 mice, which lower endogenous omega-6 polyunsaturated fatty acids, were treated with either a vehicle or estradiol benzoate (EB) and fed a high-fat diet with a high or low PUFA:SFA ratio for ~15 weeks. EB treatment reversed obesity, glucose intolerance, and bone loss in ovariectomized mice. fat-1 mice fed a 1% LA diet experienced reduced weight gain and adiposity, while those fed a 22.5% LA diet exhibited increased energy expenditure and activity in EB-treated ovariectomized mice. Coconut oil SFAs and omega-3 FAs helped protect against glucose intolerance without EB treatment. Improved insulin sensitivity was observed in wild-type and fat-1 mice fed 1% LA diet with EB treatment, while fat-1 mice fed 22.5% LA diet was protected against insulin resistance without EB treatment. The production of short-chain fatty acids by gut microbial microbiota was linked to omega-3 FAs production and improved energy homeostasis. These findings suggest that a balanced dietary fatty acid profile containing SFAs and a lower ratio of omega-6:omega-3 FAs is more effective in alleviating metabolic disorders during E2 deficiency.
DEVELOPMENT OF METHODOLOGICAL TOOLS FOR INTERNAL CONTROL OF CURRENT ASSETS IN DAIRY CATTLE
Authors: Nizamutdinov Marat , Parfenova Kseniya
Published: April 2023

Accounting and control of current assets of dairy cattle breeding in individual agricultural organizations includes the collection of information on the state and safety of various types of assets, such as cash and cash equivalents, receivables, inventory, other short-term assets, and an assessment of the effectiveness of their use in the agricultural industry. To improve the procedures for summarizing information on the current assets of dairy cattle breeding, it is advisable to use the Internal Control Working Document (hereinafter referred to as the ICWD) “The program for internal control of the movement and efficiency of the use of current assets of dairy cattle breeding”. This document is used to test the accounting system for current assets of dairy cattle and evaluate internal controls and the effectiveness of their use. For internal control of current assets at each stage of transformation, the ICWD “Checking the correctness of the assessment of current assets of dairy cattle breeding by stages of transformation” is used. During the verification process, the controller, using this document, can, at each stage of the transformation of current assets of dairy cattle breeding, give a timely and accurate assessment of these assets, which allows a more accurate idea of the actual availability of assets and their value at a certain point in time. To improve the efficiency of the internal control system, the “Regulation on Internal Control of Current Assets” can be used. The regulation regulates the accounting and internal control of current assets of dairy cattle breeding, the forms of the ICWD will help the management personnel to receive information on the value of assets in a timely manner at any stage of the production process and evaluate the effectiveness of their use. These internal control documents will allow at all stages of the transformation of current assets of dairy cattle breeding to control the movement, the correctness of the assessment and the efficiency of the use of these assets. Based on the results of the audit, summarized in the developed working documents of internal control, the management of the enterprise can make management decisions to improve the efficiency of the use of current assets of dairy cattle breeding.
PROBLEM AREAS OF RESOURCE PROVISION FOR SUSTAINABLE DEVELOPMENT OF AGRO-ECONOMIC SYSTEMS
Authors: Sitdikova Landysh , Mukhametgaliev Farit , Valiev Ayrat , Avhadiev Fayaz , Mikhaylova Valerikovna
Published: April 2023

Resource supply of sustainable development of agro-economical systems should help to increase the competitiveness of agricultural production in the domestic and world food markets and provide the population of the globe with food on the basis of steady increase of agricultural production growth rates. The analysis of the World Bank database for the period from 2012 to 2021 shows that for ten years the added value in the agrarian sector of the Russian Federation economy has increased by 16%, showing positive dynamics of the average annual growth rate with the value of 1.53%. Comparison with the analogous world average growth rate of 2.97% shows that our agro-economic system lags behind the world by almost two times. The OECD countries are developing with an average annual growth rate of 1.88%, which is also ahead of Russia’s indicators. At the same time, Russia’s agro-economic system is developing 0.26% faster than the countries of the European zone. Over the next eight years the Russian Federation expects to achieve an average annual growth rate of agricultural production of 3%, which is 2.7 times higher than the world average. For this purpose Russian agrarians have significant reserves for sustainable development of the agricultural economic system due to expansion of the areas of the main production resource by means of involving 33.04 million hectares of unused agricultural lands (16.7% of the total area) into circulation which, if successfully developed and the average Russian level of land productivity is reached, will give a 15-16% increase in production. The implementation of the program of technical modernization of agriculture can contribute to the achievement of steady annual growth rates of 1.3-1.8% of the branch production. Along with this the important directions of resource provision are the establishment of fair correlation of prices for agricultural products and industrial goods, fulfillment of financial support of agricultural development program and increasing of export potential of domestic agriculture.
SOURCE MATERIAL OF WINTER SOFT WHEAT SELECTION FOR PRODUCTIVITY AND DWARFNESS IN THE MIDDLE VOLGA FOREST-STEPPE CONDITIONS
Authors: Zakharova Nadezhda , Zakharov Nikolay , Isaychev Vitaliy
Published: April 2023

The research was carried out in order to isolate the initial material of winter soft wheat for crop breeding for high productivity, low stems and their combination in the conditions of the forest-steppe of the Middle Volga region. The work was carried out in 2011-2013 in Ulyanovsk region. The soil of the experimental field is leached chernozem, the predecessor is pure fallow. The material for the study was 102 varieties of winter wheat of various geographical origins. The weather conditions during the experiment were contrasting. Stress factors of the environment, typical for the forest-steppe of the Middle Volga region, did not allow to realize the production potential of most of the winter wheat varieties of the world collection. Varieties from Germany, Hungary, Bulgaria, Serbia, Moldova, China, USA, Japan, Estonia, Latvia formed a yield below the Volzhskaya K standard (in 2011 - 630 g/m2, in 2012 - 367 g/m2, in 2013 - 162 g/m2) by 10 ... 93%. Due to the often developing dry conditions, significant positive correlation-regression dependences of the yield of winter soft wheat on plant height (R2>0.08) were established. High-yielding sources of Poema, Biyskaya ozimaya cultivars, which annually exceeded the standard by 16...205%, were identified and recommended as the starting material for crop breeding. Dwarf and semi-dwarf wheats Donskaya lira, Zamozhnist, Yasnogorka, which have generated yields at or above the Volzhskaya K standard (499 g/m2 on average for 2011–2012 and 264 g/m2 on average for 2012–2013), are breeding value as sources of a combination of low stalks and productivity.
METHOD OF CALCULATION AND DESIGN OF SOIL DISPENSER
Authors: Gayfullin Ilnur , Haliullin Damir , Kalimullin Marat , Ziganshin Bulat , Hamitov Radik
Published: April 2023

The article considers a dispenser-distributor with soil-transporting elements, substantiates and determines its technological and design parameters. As a result of the theoretical studies carried out, analytical dependences were obtained to determine the diameter of the disk of the soil dispenser-distributor, the height of the soil-transporting element and the volume of soil required to cover potato tubers. The results of work in the field of theory and calculation of potato planters are systematized and generalized, analytical dependences are obtained to determine the main design and technological parameters of the soil dispenser-distributor of the potato planter. Based on literary sources, to obtain digital values, we chose the row spacing (70 cm), the distance between tubers (25 cm), the weight of the tuber is average (55 ... 60 g), the width at the bottom of the furrow, equal to the width of the nest, is the smallest (0 06…0.07 m), tuber planting depth (0.19 m), potato fraction – seed (50…80 g), operating speed – within (2.9…9 km/h). According to the calculations, the following results were obtained: the diameter of each disc (D=35…40 cm), the height of the soil-transporting element (hpe = 0.025 m) and the volume of soil (Ω= 0.004 m3) required to cover potato tubers.
THE EVOLUTION OF STATE REGULATION OF THE ACTIVITIES OF A SPECIALIZED AUTHORITY IN THE FIELD OF BANKRUPTCY IN THE CONTEXT OF INSOLVENCY INSTITUTION DEVELOPMENT
Authors: Akulov Andrey , Klychova Guzaliya , Ryakhovsky Dmitriy
Published: April 2023

The thirty-year history of the formation and development of the institution of bankruptcy in Russia is characterized by complex processes of transformation of the structure of its state regulation bodies. However, in practice, the institution of bankruptcy has not proven itself as an effective mechanism for regulating market relations, demonstrating an extremely low level of return on the implementation of bankruptcy procedures: if in 2015, 6.3 kopecks (6,3%) were returned to creditors from one ruble of monetary claims, then in 2021 this figure dropped to 3.5 kopecks (3,5%), which actualizes the need for further improvement of the organizational unit of the insolvency institution based on rethinking its reform experience. The purpose of this study is to identify and systematize the stages of development of the activities of a specialized state body on bankruptcy issues in the historical retrospective of the dynamic improvement of bankruptcy legislation and changes in approaches in the context of administrative reforms in the Russian Federation. As a result of the study, a periodization of the reform and identification of models of the organizational component of the system of state management of bankruptcy processes was carried out: from a centralized model with limited independence of a specialized bankruptcy authority (September 1993 - February 1998) with further strengthening of independence and expansion of its powers (March 1998 - February 2004) and the transition to a decentralized model of state bankruptcy management, when diverse functions were transferred to various state authorities in accordance with their competence, and the function of the authorized body was transferred to the Federal Tax Service of Russia. At the present stage, there is a tendency to strengthen the organizational block for ensuring bankruptcy procedures within the Federal Tax Service of Russia. From the standpoint of the synthesis of theoretical approaches, the results of judicial practice and international experience, it was concluded that the role of the authorized body in bankruptcy cases is growing, the constructive position of which contributes not only to protecting state interests, but also to increasing the efficiency of the implementation of bankruptcy procedures, reducing criminalization bankruptcies, judicial errors in the consideration of disputes in bankruptcy proceedings.