bluuebunny/crossref_metadata_2025 huggingface dataset:
Perancangan Ulang Alat Pengupas Kacang Koro Pedang Rotaris Disc dengan Metode Triz
Authors:   Universitas Katholik Widya Mandala Surabaya Indonesia, Wulandari Wahyu Sri , Laurentinus Hadi Santosa ,   Universitas Katholik Widya Mandala Surabaya Indonesia, Mulyono Julius ,   Universitas Katholik Widya Mandala Surabaya Indonesia
Published: March 2023

Sword koro (Canavalia ensiformis) is one of the local beans commonly used by the community as raw material for making tempeh. Sword M. pruriens have the advantage of being easily cultivated because they are acid-resistant and dry-resistant (Gozal, 2015). In its processing, the M. pruriens contain cyanogen glucoside (HCN) so that when consumed directly it will have a negative effect on the body. The content can be removed by heating, soaking and fermenting. Besides the processing of beans, the other most important part is the stripping process. The epidermis of the koro sword is thick enough so that if it is done traditionally it will result in fatigue for workers and requires a long time. In previous studies that have been carried out there are deficiencies in previous tools that need to be repaired, and therefore will be redesigned on these tools. Some of these parts include the dimensions of the tool, stripping space, and the position of the lever that is not right. As the main media for peeling the koro sword. By considering using anthropometric data and the TRIZ method as a medium for designing the koro sword paring tool, a solution has been obtained. The dimensions and position of the parts used are in accordance with the average height of the human body in Indonesia and the stripping space is changed from vertical to horizontal with a rotary disc.
Pengolahan Limbah Cair Industri dari PT. Sier Menggunakan Metode Elektroflotasi (EF)
Authors:   Widya Mandala Surabaya Catholic University Indonesia, Nathanael Dionysius , Agape Keenan Michael ,   Widya Mandala Surabaya Catholic University Indonesia, Anggorowati Adriana Anteng ,   Widya Mandala Surabaya Catholic University Indonesia
Published: March 2023

One of the methods for treating industrial waste is using the electro-flotation (EF) method. In this study, the EF method used requires stainless steel as the anode and aluminum as the cathode. Industrial wastewater treated using the EF method comes from PT. Surabaya Rungkut Industrial Estate (SIER). Liquid waste is put into the EF basin, then the power supply is turned on and then the voltage and contact time are adjusted. After the EF process, the treated wastewater was sampled in a certain amount to measure the value of Chemical Oxygen Demand (COD), Total Suspended Solid (TSS) and the number of bacterial colonies. Based on the calculation, the result shows that with an electric voltage of 32.5 volts and a contact time of 60 minutes, the result is the largest decrease in COD and TSS values. COD decreased from 236.66 mg / L to 24.56 mg / L or 90%, TSS decreased from 187 mg / L to 34.33 mg / L or 81.64%. While the decline in bacterial colonies from 4,7.104 to 4,03.103 or 91,42% decrease at the mains voltage of 19 volts and contact time for 20 minutes.
Analisis Pengaruh Keselamatan dan Kesehatan Kerja (K3) Dan Disiplin Kerja Terhadap Produktivitas Kerja Karyawan di PT. PLN (Persero) Area Tual
Authors:   Universitas W.R. Supratman Surabaya Indonesia, Ngabalin Eka Riksi , Cahyono Wahyu Eko ,   Universitas W.R. Supratman Surabaya Indonesia, Deviyanti I gusti Ayu Sri ,   Universitas W.R. Supratman Surabaya Indonesia
Published: March 2023

Perusahaan atau usaha industri adalah suatu unit (kesatuan) usaha yang melakukan kegiatan ekonomi, bertujuan menghasilkan barang atau jasa Keselamatan dan Kesehatan Kerja adalah suatu sistem program yang dibuat bagi pekerja maupun pengusaha sebagai upaya pencegahan ,timbulnya kecelakaan kerja dan penyakit akibat hubungan kerja dalam lingkungan kerja Rancangan penelitian merupakan rencana menyeluruh dari penelitian mencakup hal-hal yang akan dilakukan peneliti mulai dari membuat hipotesis dan implikasinya secara operasional sampai pada analisa akhir, data yang selanjutnya disimpulkan dan diberikan saran. Hasil penelitian menunjukan bahwa faktor Keselamatan dan Kesehatan Kerja (K3) dan Disiplin Kerja memiliki pengaruh terhadap Produktivitas Kerja Karyawan. Kata Kunci: PT. PLN Area Tual, Keselamatan dan Kesehatan Kerja (K3), Disiplin Kerja, Produktivitas Kerja Karyawan
Rancang Bangun Mesin Pencuci Berbagai Jenis Umbi, Rimpang dan Kacang Tanah Dengan Sinergi Rotary Rubber Brush
Authors:   Universitas Katholik Widya Mandala Surabaya Indonesia, Laurentinus Hadi Santosa , Yuliati Yuliati ,   Universitas Katholik Widya Mandala Surabaya Indonesia
Published: March 2023

Salah satu warisan leluhur dan representasi kearifan lokal yang tumbuh dan berkembang di masyarakat adalah minuman tradisional /herbal/ jamu berbahan baku rimpang empon empon. Saat ini semakin bertumbuhnya UMKM/UKM jamu/minuman tradisional/ herbal berbahan baku rimpang empon-empon yang saat ini menjadi popular dan banyak disukai oleh khalayak masyarakat. Selain rimpang, umbi-umbian dan kacang tanah juga merupakan sumber pangan yang banyak tumbuh subur di Indonesia dan industry pengolahannya pun sedang berkembang. Proses pencucian bahan baku merupakan bagian yang tidak boleh diabaikan, karena kebersihan bahan baku serta alat-alat yang digunakan berpengaruh pada kualitas pengolahan dan hasil produk olahan selanjutnya. Proses pencucian masih dilakukan secara manual / peralatan tradisional seperti kalo (anyaman dari bambu) , sikat untuk menghilangkan dan membersihkan kotoran , tanah liat yang melekat pada bahan serta di bawah air mengalir. Hal ini tentunya memerlukan air yang banyak, waktu yang lama dan seringkali hasil cucian kurang bersih dan sepenuhnya masih mengandalkan tenaga manusia. Tujuan penelitian ini adalah rancang bangun serta analisa elemen elemen mesin pencuci berbagai jenis umbi, rimpang dan kacang tanah. Metode penelitian yang digunakan adalah penelitian rekayasa teknologi atau rancang bangun teknologi. Adapun hasil penelitian ini adalah alat ini mampu meningkatkan kecepatan proses pencucian bahan baku dengan kapasitas mesin 200 km / jam. Pada sekali pencucian mampu mencuci 10 kg/ sekali pencucian dengan waktu 3-5 menit/ sekali cuci. Alat ini berpenggerak motor listrik memanfaatkan sinergi antara bagian rotary washer dan rotary rubber brush yang bergerak secara simultan sehingga dapat melakukan proses pencucian dan penyikatan sekaligus dalam melepaskan kotoran kotoran yang melekat pada bahan yang dicuci.
Upaya Peningkatan Daya Saing Ukm Tahu “Mulyo” Dengan Metode Blue Ocean Strategy
Authors:   Sekolah Tinggi Teknik Malang Indonesia, Roesdianto Rony , Herawati Lenny ,   Sekolah Tinggi Teknik Malang Indonesia, Ndari Priska Wulan ,   Sekolah Tinggi Teknik Malang Indonesia
Published: March 2023

Kota Kediri merupakan daerah yang memiliki UKM tahu yang cukup banyak, salah satunya di wilayah Desa Bawang Kota Kediri. Namun saat ini jumlah penjualan UKM tahu di Desa Bawang mengalami penurunan sebesar 50% salah satunya UKM tahu sehingga hal tersebut menyebabkan penurunan omzet penjualan. Masalah ini disebabkan oleh persaingan yang semakin ketat dimana munculnya UKM tahu di tempat lain tetapi berada di wilayah Kota Kediri, jaringan bisnis yang lemah, keuntungan yang sangat kecil. Penelitian ini bertujuan untuk memberikan saran dalam mengembangkan dan meningkatkan daya saing UKM tahu. Metodologi desain atau pendekatan yang digunakan adalah Blue Ocean Strategy untuk mengidentifikasi faktor-faktor yang mendukung strategi penjualan. Temuan yang diperoleh menunjukkan adanya faktor internal dan eksternal sebagai strategi penjualan. Dengan strategi Blue Ocean, menunjukkan stok bahan baku dengan melibatkan perbankan UKM, mereka bisa menimbun bahan baku. Kurangi, dengan menurunkan harga jual sedikit, mengubah ukuran tahu sedikit lebih kecil. Meningkat, UKM bersedia menerima bantuan pinjaman modal dalam bentuk KUR, mengikuti pelatihan. Buat, pasarkan produk tahu di supermarket, beri label pada kemasan. Keterbatasan atau implikasi dari keadaan penelitian saat ini memiliki beberapa kendala yaitu persaingan yang semakin ketat, semakin banyaknya produk sejenis, perkembangan teknologi, dan semakin banyaknya usaha sejenis. Hal ini sangat mempengaruhi bisnis yang dijalankan secara konvensional maupun UKM.
Research Progress of p-type Cuprous Oxide in the Field of Light Energy Utilization
Authors: Ren Bingbing , Mindrov K.
Published: March 2023

Cuprous oxide (Cu2O), as a representative intrinsic p-type inorganic semiconductor material, has been widely used in the field of optical energy utilization, such as photovoltaic, photocatalysis, photodegradation and other fields, and has an extremely important position. For a long time, the literature on Cu2O’s application technology in the field of light energy utilization is relatively scattered and independent, resulting in a certain degree of obstacles and difficulties to obtain relevant technical knowledge and have a deep understanding of its internal principles. According to the application of Cu2O in the field of light energy utilization in recent years, it is mainly divided into three modules (photovoltaic, photocatalysis, photodegradation), and mainly summarizes the classification, principle and characteristics of Cu2O application in the field of light energy and prospects the optimization method and development direction of the application in the field of Cu2O light energy. This review aims to provide reference and guidance for the optical energy applications of Cu2O and other related inorganic oxide semiconductors.
On the Sustainability of Individually Weighted Decisions Simple Differential Equations
Authors: Akmatov A.
Published: March 2023

The paper investigates the solution of nonlinear singularly perturbed ordinary differential equations. The eigenvalues of the Jordan matrix determine different types of stability. These types of stability include two-way stability and stability. If there is a two-sided stable domain, then solutions of linear singularly perturbed ordinary differential equations are evaluated in the real domain. Accordingly, there are two-way stable lines that we will apply when choosing the integration path. If the eigenvalues of a Jordan matrix consist of purely imaginary parts, then these eigenvalues generate a biostable region in the plane. The scientific novelty lies in the fact that these types of resistance have been discovered in the course of research, and previously published papers have not been considered. As a result, the theorem is proved and an estimate of solutions of nonlinear singularly perturbed ordinary differential equations is obtained.
Bioecological Peculiarities and Economical Significance of Scolytus intricatus (Ratzeburg, 1837) and Trypodendron lineatum (A. G. Olivier, 1800) Damaging to Forest Trees in the South Slopes of the Greater Caucasus (Azerbaijan)
Authors: Isayeva K.
Published: March 2023

Bark beetles (Curculionidae, Scolytinae) are dangerous pests of forest and fruit trees both in the world and in Azerbaijan. Their activity results in partial or complete drying out, and a decrease in quantitative and qualitative indicators of the trees. These pests are even more dangerous during the years of mass reproduction. The bark beetles, which mainly infect old trees or trees weakened by biotic, abiotic, anthropogenic factors, attack young and healthy trees during mass reproduction. These pests, which pose a threat to forestry and horticulture, have not been studied in detail in Azerbaijan. The work was carried out by the author on the southern slopes of the Greater Caucasus of Azerbaijan (Balakan, Zagatala, Gakh, Sheki, Oguz, Gabala, Ismayilli, Shamakhi and Absheron) in 2013-2019 and 22 species of bark beetles were identified damaging to forest trees. The article provides information about the bioecological characteristics and economic importance of the oak bark beetle (Scolytus intricatus (Ratzeburg, 1837)) and striped ambrosia beetle (Trypodendron lineatum (A. G. Olivier, 1800)), which are widespread in the study area and cause serious damage to forest trees. T. lineatum is new to the fauna of Azerbaijan. As a result of the activity of these pests, industrially valuable trees, such as oak, chestnut, elm, beech, pine, fir are partially or completely destroyed by drying.
Study of Helminthosesin Sheep Farms of Sheki-Zakatala Economic Region
Authors: Hasanaliev N.
Published: March 2023

At the moment, the study of helminths that affect livestock farms is one of the topical issues. The main purpose of this study was to determine the prevalence of helminthiases in individual sheep farms in the areas surrounding the Sheki-Zakatala Economic Region of the Republic of Azerbaijan. The obtained results clearly show the epizootic status of moniesiosis, dictyocaulosis, fascioliosis and dicrocellosis among helminthiases of small cattle in the region, depending on age groups, landscapes, seasons, extensiveness (EI) and invasion intensity. As a result of the study of the epizootic state of the region, 3194 heads were analyzed. In addition, 403 post-mortem examinations were carried out. So, a total of 3591 sheep heads were studied and, on the basis of these results, an analysis of the epizootic situation in this region was carried out.
Cognitive Brain: Neuroscience, Neurophysiology and Neuroendocrinology of Emotions
Authors: Romanchuk N.
Published: March 2023

Humancognitive brain integrates and synchronizes neurobiological, neurophysiological, and neuroendocrinological emotions that promote compassion and intersubjectivity that will help reduce stress and enhance compassionate mediation to resolve conflicts. The dependence of emotional states on context is also critical for affective neurology studies in which we want to experimentally manipulate emotional states. Emotions are functional states realized in the activities of neural systems that regulate complex behavior. Strategic is the creation of an integrative working model of emotions and stress, which specifies a time frame for measuring stress: acute, event, daily and chronic and a more accurate language for measuring stress. Human cognitive brains are biological, biophysical, neurophysiological, and medico-social information exchange paradigms. Modern artificial intelligence technologies are capable of many things, including predicting cognitive impairment and cognitive disorders, using combined and hybrid neuroimaging, next-generation sequencing, etc., in order to begin timely and effective rehabilitation of the Human brain. Social feelings have conceptual and empirical links to affect and emotion. The modern problem of affective neurology is to detail causal interactions between emotional states, emotion experiences, and emotion concepts: in healthy adults, all three usually occur together. Emotional states, along with many other signs of mental state, provide causal explanations for behavior. Emotions are “purposeful” because they are aimed at preparing the body to respond to situations that have repeatedly arisen throughout evolution. In conceptual stages of development, emotions become more differentiated and diverse as the cognitive brain of Human (individual, person, personality) postpones memories of emotional events often caused by social interactions, assesses situations, and develops coping mechanisms, including expectation, appropriate levels of arousal, and cognitive control of emotional behavior. Human brain working in the mode of genius (talent, creativity) requires the creation and maintenance of modern neurocompunctions between the new cortex and the hippocampus (memory library, memory hard drive), the formation of new structural and functional neurocompunctions in Human brain that occur continuously throughout the life of all life from birth to ultra-longevity and have creative advantages in the era of modern neuroscience and neuromarketing.
Evaluation of the Efficiency of Comprehensive Rehabilitation of Patients with Diabetic Polyneuropathy in Outpatient Conditions
Authors: Alybaeva S. , Mambetov M.
Published: March 2023

The study was carried out on the basis of a medical rehabilitation center — a branch of the Kyrgyz Research Institute of Balneology and Rehabilitation Treatment. 155 patients with type 2 diabetes mellitus with diabetic neuropathy of the lower extremities were observed before and after the course of rehabilitation. The effectiveness of rehabilitation is most pronounced after 3 months and is about 75%. For long-term preservation of the positive effect and prevention of diabetic foot, repeated courses are recommended after 6 months.
Specificities of Engineering of Training Information Systems With Virtual Electronic Tutoring Devices
Authors: Tsybov N. , Galbaev Zh.
Published: March 2023

In the study of engineering disciplines, special attention is paid to students’ participation in conducting scientific experiments. But not all experiments can be implemented in physical laboratories due to the high cost and great complexity. In such cases, information technologies provide an opportunity to create virtual learning systems, a kind of which is cognitive training information systems, including virtual tutoring devices. The methodological basis for researching the components of virtual tutoring devices and training informational system as a whole was the complex application of mutually complementary approaches and methods, the main of which were methods of decomposition, aggregation, structural and cognitive analysis. One of the most significant shortcomings of existing training information systems is their low didactic efficiency, therefore, the purpose of this article is to create virtual electronic training devices as part of cognitive learning systems which functioning algorithms take into account the education process participant’s personal qualities and thereby provide the opportunity of using a student-oriented approach in education. The article presents schematic solutions for the engineering of training information systems, which include virtual models of precision power systems and precision amplification systems. By building powerful power supply systems, it was possible to fully compensate the instability of the output voltage when the load current changes up to 50 A. Solutions were also proposed to create broadband amplifiers with a harmonic coefficient of 0.003%. The work proposes schematic solutions for virtual electronic training devices that can provide students with nodes of various complexities in engineering. The work presents methods for increasing the didactic efficacy of the use of training information systems.
Experimental Seed Cleaner and Its Calibration
Authors: Khasmamedli I.
Published: March 2023

The relevance of the requirements for improving the quality of seed cleaning and calibration machines in seed production is emphasized, in this direction, a constructive improvement option has been developed as a working hypothesis for the purpose of conducting research. conditions are created for the passage of the entire cleaned and calibrated seed material through a separate sieve at the separation and purification stage. During the study, the specific load of the grain mass, the frequency of vibrations of the working organ and the angle of inclination relative to the horizon changed, the fraction separated from the lower layer of the grain mass changed, the effect on the quantity was determined.
Economic Development of the Region and Its Structural Components (on the Example of the Orel Region)
Authors: Marchenkova L.
Published: March 2023

Differences in the level of socio-economic development of regions are determined by many conditions and factors, such as: economic, social, political, natural, human, environmental, etc. The main goal of analyzing the socio-economic development of the region is to improve the conditions and quality of life. The article deals with the socio-economic development of the region (on the example of the Oryol region). The author analyzed the dynamics of the main macroeconomic indicators of the region, identified the problems of the region's development, outlined the prospects for the socio-economic development of the region. The assessment of the socio-economic development of the region was carried out using the average values of socio-economic indicators for two and three years. The analysis revealed an imbalance in the dynamics of the main socio-economic indicators of the development of the Oryol region. Some indicators characterized the growth of socio-economic development, others — its decline. An important aspect of the analysis was the consideration of the “Strategy for the socio-economic development of the Oryol region until 2035” in the main areas of its functioning. The effectiveness of the implementation of the planned activities was revealed, the selected indicators were studied, and the degree of their achievement was considered. The result of the study was the author’s view on the definition of the current situation of socio-economic development of the region. The main directions for improving the socio-economic development of the region are proposed, as well as the main methodological provisions are developed, cause-and-effect relationships are identified and priority directions for the development of the Oryol region are substantiated. The modern development of the Oryol region, both at the micro and macro levels, should be aimed at the active use of innovative resources, which will ensure sustainability in its socio-economic development.
Ecological Marketing
Authors: Mishacheva E.
Published: March 2023

The article reveals the essence of environmental marketing, what are its goals. The methods of implementing the marketing concept are described in detail. The necessity of using environmental marketing is substantiated. The opinions of various groups of scientists regarding the implementation of the ecomarketing concept in the company are given. There are 4 levels of implementation of the concept of environmental marketing in accordance with the concept of 4P by E. Jerome McCarthy.
Peculiarities of Formation of Professional Motivation of Students of Pedagogical Specialties in the Educational Process at Higher Educational Institution
Authors: Umarov T. , Koshonova S. , Begmatov S.
Published: March 2023

The article presents the results of an experimental study of the features of the formation of professional motivation of students of the pedagogical profession in the process of studying at a university. The former professional motivation of students of pedagogical specialties forms a competent, mobile, responsible future schoolteacher with a stable system of spiritual and moral values. The formation of professional motivation of students of pedagogical specialties is a psychological and pedagogical process that requires methods of diagnosis, analysis and development. The purpose of our research is to develop a model and program for the formation of professional motivation of students of pedagogical specialties and to determine the psychological and pedagogical conditions for the formation of professional motivation. The pedagogical conditions of students of pedagogical specialties are theoretically determined: ex-ternal (activation of activity) and internal (awareness of their own abilities, motivation for professional maturation, internal professional identity of the student; creative activity, readiness for professional self-improvement). The practical significance of the study lies in the fact that the results of the study can be used to diagnose and correct the professional motivation of students of pedagogical specialties, motivational training programs during training sessions. In order to form the professional motivation of students of pedagogical specialties, a model and a program for the formation of professional motivation in the form of a formative experiment have been developed and introduced into the educational process. Improving the efficiency of educational and professional activities of students of the experimental group, the formation of professional motivation of students, allows us to talk about one of the most important mechanisms for improving the professional development of students of pedagogical specialties.
Formation of Professional Competencies Based on Independent Activity of Students
Authors: Toroev Y. , Rasulova Z.
Published: March 2023

This article discusses some features of the process of forming professional competencies based on the planning, organization and management of independent work of students. The author reveals the experience of working on the formation and development of professional competencies in new conditions. At the same time, the main emphasis is on the creative work and motivation of the student. Independent work of a student is an integral part of the training of qualified specialists in higher educational institutions. A feature of modern professional training of students is the predominant nature of individual and independent work. The materials of the article and its conclusions can be useful for students, teachers, postgraduates and researchers interested in the problems of the formation of professional competence and independent work of correspondence students.
Research Competence of College Students as a Subject of Pedagogical Analysis
Authors: Tanikulova A.
Published: March 2023

The urgency of the problem of the formation of research competence is increasing in the new socio-economic conditions, the formation of market relations and the digital society, in which a critical look at the problem, the ability to reflectively assess events and phenomena, the formation of research skills, the ability to adapt to changing situations, uncertainty, unpredictability. In this regard, this article is devoted to the issues of pedagogical aspects of the development of the education system and its influence on the formation of design, survey and research abilities of college students. The development of scientific and research abilities of college students to a certain extent depends on the existing education system. As you know, a person, in addition to satisfying his vital needs, needs to satisfy spiritual needs that are directly related to his desire for knowledge, education. research activities in the thinking of college students. At all levels of education of children and young people, there is no proper training in the methods of forming research activity in the thinking of college students, developing skills in its observance and reducing motivation for adequate behavior. No less important is the problem of the formation of research activity in the thinking of young students. At present, there is a need to resolve the contradictions that have arisen between the conditions of social life and the conditions existing in modern educational institutions in which the education of students is realized. The formation of a culture of formation of research activity in the thinking of college students today is a priority state task.
Traditional and Innovative Methods Used by Mathematics Students to Develop Professional Communication in English
Authors: Bekmatova Zh.
Published: March 2023

There is a long overdue need to apply methods in higher mathematical vocational education in Kyrgyzstan that promote the development of professional communication of students who find their place in developed countries and show good results. However, the conceptual directions of the management of such activities have not been fully formed. The article points out the role of mathematics in vocational education for Kyrgyz youth in conditions aimed at countering competition of international importance, keeping up with global competition on the scientific and theoretical level.
The Structure of Substances in the Course of Chemistry of the Secondary School and the Method of Teaching Initial Concepts of Structure
Authors: Yarmatov M. , Umarova N. , Ashirbekova М. , Osmonova A. , Abdyrakhmanova Zh.
Published: March 2023

This article is devoted to improving the quality of education using modern methods of teaching the first concepts of the structure of substances in the chemistry course of secondary school. The chemistry course also teaches that the properties of substances are related to their structure and the formation of these properties in students. Research objectives: to give the basic concepts of the structure of substances in the course of chemistry and to familiarize students with the initial laws. Research materials and methods: lesson planning of the theme of the structure of substances, drawing up a diagram of the structure of substances and their physical properties. Research results: when creating a diagram of the history of substances, students used the skills of comparison and inference, which ensure the activation of mental activity. Conclusions: the first understandings about two types of matter (molecular and non-molecular structure) are firmly acquired by students in the following topics and are easily deepened and expanded.
Main Political and Ideological Views of the SRs: Formation and Character
Authors: Protasova O.
Published: March 2023

The article examines the key components of the political doctrine of the Socialist-Revolutionary Party, which represented the populist trend in Russian socialism in the late 19th - first quarter of the 20th centuries. The diversity of ideological and philosophical directions in the ranks of the Socialist-Revolutionary Party is shown, which ensured internal democracy, but hampered the process of consolidation and centralization of the party. The stage of formation of party programmatic, long and sharply debatable, is characterized. The features of the nature of the programmatic views of the Socialist-Revolutionary Party on the main socially significant points, including state-legal and agrarian ones, are revealed. The classical populist attitude of the Socialist-Revolutionaries to the issue of the social structure and stratification of Russia is noted — with the recognition as a progressive class of the entire “working people”, including workers, the working peasantry and the working (socialist-minded) intelligentsia. The Socialist-Revolutionary Party was assessed as an organization that adhered to the principles of democracy and pluralism in its political practice.
Forensic Linguistic Examination at the Joint of Language and Law in the Kyrgyz Republic
Authors: Semenova Zh.
Published: March 2023

This article is devoted to the problem of linguistic expertise, the relationship between language and law. The need for linguistic knowledge in the field of forensic activities is given the opportunity to discover new expert structures. Linguistic expertise is one of the evidence base in civil and criminal proceedings. Also, this article reflects the legal and linguistic aspects for solving urgent social problems. In this area, linguistics and jurisprudence are closely interconnected. If the conflict text is subject to linguistic research, then its resolution is of a legal nature. Legal discourse has a special place in the relationship between language and law, since language determines the nature and nature of law. The object of linguistic expertise can be not only legal, but also any discourse, since the subject of expert research is determined by its purpose and objectives and is characterized by its diversity. Therefore, linguistic expertise is a special and meaningful area of research that differs significantly from other branches of legal linguistics. Linguistic expertise is an established scientific and practical field with a well-known history in other countries. In the Kyrgyz Republic, forensic linguistic expertise already has a strong place in the procedural action, since every year there is an increase in materials in the production of forensic examinations relating to linguistic examinations. Thus, the article gives a brief description of linguistic expertise, which is the subject of legal linguistics.
Synergies of feed, management trainings, and genetics on milk production of dairy cows in the tropics: The case of Ethiopian smallholder farmers
Authors: Hatew Bayissa , Peñagaricano Francisco , Balehegn Mulubrhan , Jones Chris S. , Dahl Geoffrey E. , Adesogan Adegbola T.
Published: March 2023

Efforts made so far to increase milk production of indigenous cattle by upgrading with exotic genotypes through crossbreeding under smallholder farmer conditions in Ethiopia have resulted in limited improvement. This study was conducted to determine if combining improved feed and management-related trainings with Holstein genetics will synergistically increase the milk production of dairy cows, and to examine the degree to which the increase or improvement is related to the level of exotic genetics involved. A total of 96 smallholder dairy farmers were purposively selected and allocated to one of three treatments reflecting differing degrees of capacity building support: (1) no training and no material support (Control); (2) training provided by another project (PAID) but without material support; (3) enhanced training plus material support (Feed-Mgt). Sixteen extension development agents and eight livestock experts were selected to provide training and weekly on-farm data collection, monitoring, technical support, and messaging reinforcement visits. Enhanced training addressed a broad range of topics related to feed and feeding, improved forage production, milk production and handling, construction and use of improved dairy housing, disease control, and dairy farm record keeping. Material support was in the form of formulated dairy concentrate feed and improved forage planting materials (seeds/seedlings). Data collection included variables describing animal performance, management practice adoption, and milk and butter quality. Tail hair samples for genetic profiling of breed makeup were also collected from all cows in the study. Results showed that there was a very significant effect of treatment (P < 0.001) on milk production, as well as treatment by week interaction (P = 0.034), with the effect of treatment markedly increasing over time (P = 0.032). That is, cows in Feed-Mgt group had up to 26.6% greater milk production compared to those in the Control group. Region and region by treatment interaction have no effects. Cows used in the experiment had varying proportions of Holstein-Friesian genome that ranged between 0 and 100%, suggesting prevalence of indiscriminate crossbreeding. Cows with a high proportion of Holstein genetics in treatment 3 produced more milk as compared to those in control group. Besides, supplemental feed improved body condition, reduced number of services per conception and resulted in higher lactation length of cows on treatment 3 compared with those on treatments 1 and 2 (P < 0.001). Overall, our findings suggest that an integrated approach of improved feed, feeding practices, and management training for smallholder dairy that goes beyond the improvement of genetics will increase milk production, improve milk quality and body condition, and resulted in higher length of lactation.
Enhanced hybrid hydrogel based on wheat husk lignin-rich nanocellulose for effective dye removal
Authors: Huang Rong , Xu Yong , Kuznetsov Boris N. , Sun Meitao , Zhou Xin , Luo Jing , Jiang Kankan
Published: March 2023

Polyvinyl alcohol (PVA) hydrogels were enhanced mechanically through the addition of lignin-rich nanocellulose (LCN), soluble ash (SA) and montmorillonite (MMT) for dye removal. The hybrid hydrogels reinforced with 33.3 wt% of LCN had a 163.0% increase in storage modulus as compared to the PVA/0LCN-33.3SM hydrogel. LCN can be added to the PVA hydrogel to alter its rheological properties. Additionally, hybrid hydrogels were highly efficient in removing methylene blue from wastewater, which was attributed to the synergistic effects of the PVA matrix supporting embedded LCN, MMT, and SA. The adsorption time (0–90 min) showed that the hydrogels containing MMT and SA had high removal efficiency, and the adsorption of methylene blue (MB) by PVA/20LCN-13.3SM was greater than 95.7% at 30°C. It was found that MB efficiency decreased with a high MMT and SA content. Our study provided a new method for the fabrication of polymers-based eco-friendly, low-cost and robust physical hydrogels for the MB removal.
Proteomic characterization of extracellular vesicles released by third stage larvae of the zoonotic parasite Anisakis pegreffii (Nematoda: Anisakidae)
Authors: Palomba Marialetizia , Rughetti Aurelia , Mignogna Giuseppina , Castrignanò Tiziana , Rahimi Hassan , Masuelli Laura , Napoletano Chiara , Pinna Valentina , Giorgi Alessandra , Santoro Mario , Schininà Maria Eugenia , Maras Bruno , Mattiucci Simonetta
Published: March 2023

Introduction

Anisakis pegreffii is a sibling species within the A. simplex (s.l.) complex requiring marine homeothermic (mainly cetaceans) and heterothermic (crustaceans, fish, and cephalopods) organisms to complete its life cycle. It is also a zoonotic species, able to accidentally infect humans (anisakiasis). To investigate the molecular signals involved in this host-parasite interaction and pathogenesis, the proteomic composition of the extracellular vesicles (EVs) released by the third-stage larvae (L3) of A. pegreffii, was characterized.

Methods

Genetically identified L3 of A. pegreffii were maintained for 24 h at 37°C and EVs were isolated by serial centrifugation and ultracentrifugation of culture media. Proteomic analysis was performed by Shotgun Analysis.

Results and discussion

EVs showed spherical shaped structure (size 65-295 nm). Proteomic results were blasted against the A. pegreffii specific transcriptomic database, and 153 unique proteins were identified. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analysis predicted several proteins belonging to distinct metabolic pathways. The similarity search employing selected parasitic nematodes database revealed that proteins associated with A. pegreffii EVs might be involved in parasite survival and adaptation, as well as in pathogenic processes. Further, a possible link between the A. pegreffii EVs proteins versus those of human and cetaceans’ hosts, were predicted by using HPIDB database. The results, herein described, expand knowledge concerning the proteins possibly implied in the host-parasite interactions between this parasite and its natural and accidental hosts.
In silico and in vitro evaluation of antiviral activity of wogonin against main protease of porcine epidemic diarrhea virus
Authors: Wang Jieru , Zeng Xiaoyu , Yin Dongdong , Yin Lei , Shen Xuehuai , Xu Fazhi , Dai Yin , Pan Xiaocheng
Published: March 2023

The high mortality rate of weaned piglets infected with porcine epidemic diarrhea virus (PEDV) poses a serious threat to the pig industry worldwide, demanding urgent research efforts related to developing effective antiviral drugs to prevent and treat PEDV infection. Small molecules can possibly prevent the spread of infection by targeting specific vital components of the pathogen’s genome. Main protease (Mpro, also named 3CL protease) plays essential roles in PEDV replication and has emerged as a promising target for the inhibition of PEDV. In this study, wogonin exhibited antiviral activity against a PEDV variant isolate, interacting with the PEDV particles and inhibiting the internalization, replication and release of PEDV. The molecular docking model indicated that wogonin was firmly embedded in the groove of the active pocket of Mpro. Furthermore, the interaction between wogonin and Mpro was validated in silico via microscale thermophoresis and surface plasmon resonance analyses. In addition, the results of a fluorescence resonance energy transfer (FRET) assay indicated that wogonin exerted an inhibitory effect on Mpro. These findings provide useful insights into the antiviral activities of wogonin, which could support future research into anti-PEDV drugs.`
Oncolytic viruses-modulated immunogenic cell death, apoptosis and autophagy linking to virotherapy and cancer immune response
Authors: Wu Yi-Ying , Sun Te-Kai , Chen Ming-Shan , Munir Muhammad , Liu Hung-Jen
Published: March 2023

Recent reports have revealed that oncolytic viruses (OVs) play a significant role in cancer therapy. The infection of OVs such as oncolytic vaccinia virus (OVV), vesicular stomatitis virus (VSV), parvovirus, mammalian reovirus (MRV), human adenovirus, Newcastle disease virus (NDV), herpes simplex virus (HSV), avian reovirus (ARV), Orf virus (ORFV), inactivated Sendai virus (ISV), enterovirus, and coxsackievirus offer unique opportunities in immunotherapy through diverse and dynamic pathways. This mini-review focuses on the mechanisms of OVs-mediated virotherapy and their effects on immunogenic cell death (ICD), apoptosis, autophagy and regulation of the immune system.
Lateralized connectivity in the alpha band between parietal and occipital sources when spatial attention is externally and internally directed
Authors: Van der Lubbe Rob H. J. , Panek Bartłomiej , Jahangier Ivania , Asanowicz Dariusz
Published: March 2023

Introduction

External spatial attention refers to the selection of currently present information at a specific external location, whereas internal spatial attention refers to the selection of stored information in short-term memory initially presented at a specific location. Electroencephalographic (EEG) and magnetoencephalographic (MEG) studies revealed that these two types of selection may involve the same underlying neural mechanism as in both cases a reduction in posterior alpha power was observed. However, the posterior alpha rhythm may consist of different components, which can even be related to opposite behavioral effects. Furthermore, the employed paradigms to study both selection processes are often quite different, which makes a proper comparison cumbersome.

Methods

In the current EEG experiment, two-stimulus displays were preceded or followed by non-spatial pre-cues and post-cues that specified the target, thereby minimizing procedural differences.

Results

Results of time-frequency analyses revealed that in both cue conditions the selection of relevant information was associated with an increase of ipsilateral vs. contralateral posterior alpha power. An opposite effect, an increase in contralateral vs. ipsilateral posterior power was observed in the theta-band, but only in the pre-cue condition. This activity was related to stimulus onset and likely reflects target selection. To assess attention-related connectivity, we separated posterior alpha power in a medial-parietal and two parieto-occipital sources and computed alpha phase coherence between these sources. Results revealed that in both cue conditions, increased ipsilateral vs. contralateral connectivity in the alpha band was present between the medial-parietal and parieto-occipital sources.

Discussion

The results seem to reflect a modulation from parietal to occipital areas, providing support for the view that internal and external spatial attention share a common neural mechanism.
Parsley Health: Feasibility and acceptability of a large-scale holistic telehealth program for chronic disease care
Authors: Williams Hants , Steinberg Sarah , Vingum Ryan , Leon Kendall , Céspedes Elena , Berzin Robin , Hagg Heather
Published: March 2023

Background

A holistic, personalized approach to medicine can be used to prevent and manage a variety of chronic diseases. However, effectively managing chronic diseases can be difficult due to barriers related to insufficient provider time, staffing, and lack of patient engagement. To address these challenges telehealth strategies are being increasingly adopted, yet few studies have explored how to evaluate the feasibility and implementation success of large-scale holistic telehealth models for chronic disease care. The aim of this study is to assess the feasibility and acceptability of a large-scale holistic telehealth program for the management of chronic diseases. Our study findings can inform the future development and assessment of chronic disease programs delivered through telehealth strategies.

Methods

Data was collected from participants enrolled in a Parsley Health membership from June 1, 2021 to June 1, 2022, a subscription-based holistic medicine practice designed to help people prevent or manage chronic diseases. Implementation outcome frameworks were used to understand engagement with services, participant satisfaction, and preliminary effectiveness of the program via a patient-reported symptom severity tool.

Results

Data from 10,205 participants with a range of chronic diseases were included in our analysis. Participants averaged 4.8 visits with their clinical team and reported high levels of satisfaction with their care (average NPS score of 81.35%). Preliminary evidence also showed substantial reduction in patient reported symptom severity.

Conclusion

Our findings suggest the Parsley Health program is a feasible and acceptable large-scale holistic telehealth program for chronic disease care. Successful implementation was due, in part, to services that promoted participant engagement along with tools and interfaces that were helpful and easy to use. These findings can be used to develop future holistic-focused telehealth programs for the management and prevention of chronic diseases.
Modulation of the solar activity on the connection between the NAO and the tropical pacific SST variability
Authors: Huo Wenjuan , Xiao Ziniu , Zhao Liang
Published: March 2023

Previous studies indicated that the North Tropical Atlantic (NTA) SST can serve as a precursor for the El Niño–Southern Oscillation (ENSO) predictability and the connection of NTA-ENSO is modulated by the mid-high latitude atmospheric variability. Despite significant solar footprints being found in the North Atlantic and tropical Pacific separately, their role in the two basins’ connection is still missing. In this study, we systematically examined this point by using observational/reanalysis datasets and outputs of a pair of sensitivity experiments with and without solar forcings (SOL and NOSOL). In observations, DJF-mean NAO-like SLP anomalies have a linear covariation with the subsequent JJA-mean El Niño Modoki-like SST anomalies in the tropical Pacific in the following 1 year. This observed SLP-SST covariation shows up in the high solar activity (HS) subset and disappears in the low solar activity (LS) subset. In the HS years, positive NAO-like SLP anomalies are produced by the stronger solar-UV radiation through a “top-down” mechanism. These atmospheric anomalies can enhance the influence of the NTA on the tropical Pacific SST by triggering significant and more persistent subtropical teleconnections. Here we proposed an indirect possible mechanism that the solar-UV forcing can modulate the tropical Pacific SST variability via its impacts on the atmospheric anomalies over the North Atlantic region. However, based on the same analysis method, we found a different coupled mode of the SLP and SST anomalies in the modeling outputs. The SLP anomalies in the North Atlantic, with a triple pattern (negative SLP anomalies in the Pole and the NTA, positive SLP anomalies in the mid-latitude), have “lead-lag” covariations with the Eastern Pacific El Niño-like SST anomalies in both the SOL and NOSOL. Although the impact of the solar activity is found in the North Atlantic and the tropical Pacific respectively in the SOL, no solar effect is involved in the simulated SLP-SST coupled mode.