bluuebunny/crossref_metadata_2025 huggingface dataset:
RETRACTED: When Words Hurt: Affective Word Use in Daily News Coverage Impacts Mental Health
Authors: Wormwood Jolie B. , Devlin Madeleine , Lin Yu-Ru , Barrett Lisa Feldman , Quigley Karen S.
Published: August 2018

Media exposure influences mental health symptomology in response to salient aversive events, like terrorist attacks, but little has been done to explore the impact of news coverage that varies more subtly in affective content. Here, we utilized an existing data set in which participants self-reported physical symptoms, depressive symptoms, and anxiety symptoms, and completed a potentiated startle task assessing their physiological reactivity to aversive stimuli at three time points (waves) over a 9-month period. Using a computational linguistics approach, we then calculated an average ratio of words with positive vs. negative affective connotations for only articles from news sources to which each participant self-reported being exposed over the prior 2 weeks at each wave of data collection. As hypothesized, individuals exposed to news coverage with more negative affective tone over the prior 2 weeks reported significantly greater physical and depressive symptoms, and had significantly greater physiological reactivity to aversive stimuli.
Role of Pseudogenes in Tumorigenesis
Authors: Hu Xinling , Yang Liu , Mo Yin-Yuan
Published: August 2018

Functional genomics has provided evidence that the human genome transcribes a large number of non-coding genes in addition to protein-coding genes, including microRNAs and long non-coding RNAs (lncRNAs). Among the group of lncRNAs are pseudogenes that have not been paid attention in the past, compared to other members of lncRNAs. However, increasing evidence points the important role of pseudogenes in diverse cellular functions, and dysregulation of pseudogenes are often associated with various human diseases including cancer. Like other types of lncRNAs, pseudogenes can also function as master regulators for gene expression and thus, they can play a critical role in various aspects of tumorigenesis. In this review we discuss the latest developments in pseudogene research, focusing on how pseudogenes impact tumorigenesis through different gene regulation mechanisms. Given the high sequence homology with the corresponding parent genes, we also discuss challenges for pseudogene research.
The Carbon Sequestration Potential of Degraded Agricultural Land in the Amhara Region of Ethiopia
Authors: Belay Beyene , Pötzelsberger Elisabeth , Hasenauer Hubert
Published: August 2018

Forests are a key player within the global carbon cycle and reforestation is an important climate change mitigation mechanism. In this study, we identify potentially suitable areas for reforestation to assess the carbon sequestration potential in the highly deforested and degraded Amhara region of Ethiopia. We apply biogeochemical mechanistic ecosystem modelling to predict the amount of carbon that can be potentially sequestered within different time horizons. Since human intervention plays a key role within the Amhara region, three different forest management scenarios and five different rotation periods following reforestation are tested: (i) unthinned; (ii) removal of 5% of the stem carbon every 20 years (thinning 1); and (iii) removal of 10% stem carbon every 20 years (thinning 2), as well as a rotation period of 10, 30, 50, 100, and 150 years. Sustainable management of reforested land is addressed by implementing the so called ‘Normal-forest’ system (equal representation of every age class). This ensures the long term sequestration effect of reforested areas. The study shows that 3.4 Mha (Mha = Million hectare) of land, including bare land (0.7 Mha), grass land (1.2 Mha), and shrub land (1.5 Mha) can be considered as ecologically potentially suitable for reforestation. Assuming a 100 year rotation period in a ‘Normal-forest’ system, this shows that a total net carbon sequestration potential of 177 Tg C (10.8 Tg C in the soil and 165.9 Tg C aboveground; Teragram = 1012 g) is possible, if all 3.4 Mha are replanted. The highest total net carbon sequestration (soil and aboveground) was evident for the Highland-wet agro-ecological zone, whereas the lowest values are typically in the Midland-dry zone. The highest net aboveground carbon sequestration was predicted for reforestations on current grass land and shrub land versus bare land, whereas the highest net soil carbon sequestration was predicted on current bare land, followed by grass land and shrub land.
The Effects of Social Exclusion and Group Heterogeneity on the Provision of Public Goods
Authors: Njozela Lindokuhle , Burns Justine , Langer Arnim
Published: August 2018

The multi-dimensional nature of social exclusion requires several perspectives in understanding its causes and consequences. Focus on the topic is largely centred around questions of material deprivation. However, as poverty and inequality are inextricably linked to questions of access and inclusion, a holistic approach is required. Consequently, we explore how imposed relational asymmetries which manifest as differences in the ability to exercise personal agency and in turn, engender wealth inequalities, affect social cooperation in future interactions. To do this, we generate wealth inequalities through two Prisoner’s Dilemma games, where one party is excluded from participating in the determination of the outcomes of the game. The effects of this asymmetry in social participation on ex post cooperation is examined using a Public Goods game. We find that the presence of prior asymmetric influence in social decision-making subsequently reduces contributions to the public good, independent of endowment level. This reduction in social welfare is driven by the under-contribution from players who were excluded in prior social interactions. Simply put, the data shows that a history of social exclusion reduces subsequent public goods provision, independent of material inequality.
A High-Quality, Long-Read De Novo Genome Assembly to Aid Conservation of Hawaiiʻs Last Remaining Crow Species
Authors: Sutton Jolene T. , Helmkampf Martin , Steiner Cynthia C. , Bellinger M. Renee , Korlach Jonas , Hall Richard , Baybayan Primo , Muehling Jill , Gu Jenny , Kingan Sarah , Masuda Bryce M. , Ryder Oliver A.
Published: August 2018

Genome-level data can provide researchers with unprecedented precision to examine the causes and genetic consequences of population declines, which can inform conservation management. Here, we present a high-quality, long-read, de novo genome assembly for one of the world’s most endangered bird species, the ʻAlalā (Corvus hawaiiensis; Hawaiian crow). As the only remaining native crow species in Hawaiʻi, the ʻAlalā survived solely in a captive-breeding program from 2002 until 2016, at which point a long-term reintroduction program was initiated. The high-quality genome assembly was generated to lay the foundation for both comparative genomics studies and the development of population-level genomic tools that will aid conservation and recovery efforts. We illustrate how the quality of this assembly places it amongst the very best avian genomes assembled to date, comparable to intensively studied model systems. We describe the genome architecture in terms of repetitive elements and runs of homozygosity, and we show that compared with more outbred species, the ʻAlalā genome is substantially more homozygous. We also provide annotations for a subset of immunity genes that are likely to be important in conservation management, and we discuss how this genome is currently being used as a roadmap for downstream conservation applications.
The Transition from Occupational Safety and Health (OSH) Interventions to OSH Outcomes: An Empirical Analysis of Mechanisms and Contextual Factors within Small and Medium-Sized Enterprises
Authors: Micheli Guido J. L. , Cagno Enrico , Calabrese Antonio
Published: August 2018

Many Occupational Safety and Health (OSH) interventions have proven to be effective only under controlled conditions; during the implementation in practice, the interventions may not work as expected, especially in small and medium-sized enterprises (SMEs). SMEs are affected by different contextual factors than larger enterprises and these factors can influence the outcome of the OSH programs. Three different phases of an OSH intervention (design, implementation, and control) have been considered. The aim of this research is to understand what are the mechanisms by which an OSH intervention works or does not work as expected, together with barriers and drivers, and the related contextual factors. The research was designed following multiple case study research, which enables an in depth understanding of the intervention process and the identification of the most relevant factors for OSH. Data were collected through interviews with owner-managers or OSH managers of SMEs. Finally, the data were analysed through an analytical research framework that enabled the identification of the main mechanisms and contextual factors for the interventions that had an expected outcome and for those which had an unexpected outcome.
Towards a Greater Understanding of Suicidal Behaviour and Its Prevention
Authors: Sisask Merike , Kõlves Kairi
Published: August 2018

Suicidal behaviour continues to be an important topic of research and significant public health concern globally [...]
Synthesis, Biological Evaluation and Molecular Docking of Novel Indole-Aminoquinazoline Hybrids for Anticancer Properties
Authors: Mphahlele Malose J. , Mmonwa Mmakwena M. , Aro Abimbola , McGaw Lyndy J. , Choong Yee Siew
Published: August 2018

A series of indole-aminoquinazolines was prepared via amination of the 2-aryl-4-chloroquinazolines with the 7-amino-2-aryl-5-bromoindoles. It was then evaluated for cytotoxicity in vitro against human lung cancer (A549), epithelial colorectal adenocarcinoma (Caco-2), hepatocellular carcinoma (C3A), breast adenocarcinoma (MCF-7), and cervical cancer (HeLa) cells. A combination on the quinazoline and indole moieties of a 2-phenyl and 2-(4-fluorophenyl) rings in compound 4b; 2-(4-fluorophenyl) and 3-chlorophenyl rings in compound 4f; or the two 2-(4-fluorophenyl) rings in compound 4g, resulted in significant and moderate activity against the Caco-2 and C3A cell lines. The indole-aminoquinazoline hybrids compounds 4f and 4g induced apoptosis in Caco-2 and C3A cells, and were also found to exhibit moderate (IC50 = 52.5 nM) and significant (IC50 = 40.7 nM) inhibitory activity towards epidermal growth factor receptor (EGFR) against gefitinib (IC50 = 38.9 nM). Molecular docking suggests that 4a–h could bind to the ATP region of EGFR like erlotinib.
Cognitive Impairment and Celiac Disease: Is Transcranial Magnetic Stimulation a Trait d’Union between Gut and Brain?
Authors: Lanza Giuseppe , Bella Rita , Cantone Mariagiovanna , Pennisi Giovanni , Ferri Raffaele , Pennisi Manuela
Published: August 2018

Celiac disease is a systemic disorder with multifactorial pathogenesis and multifaceted symptomatology. In response to gluten exposure, a significant part of the general population produces antibodies that have been hypothesized to be deleterious to the brain. Among the well-known neurological manifestations, adult celiac patients often complain cognitive symptoms, ranging from the so-called “brain fog” till an overt dementia. Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation technique that can contribute to the assessment and monitoring of celiac patients, even in those without a clear neurological involvement. The studies here reviewed seem to converge on an impaired central motor conductivity and a “hyperexcitable celiac brain” to TMS, which partially reverts back after a long-term gluten restriction. Notably, a clear hyperexcitability is a stably reported feature of both degenerative and vascular dementia. Therefore, given its potential neuroprotective effect, the gluten-free diet should be introduced as early as possible, although the overall response of neurological symptoms (and cognition in particular) is still controversial. Identifying new and possibly modifiable risk factors may be of crucial importance for patients, clinicians, and researchers.
Anti-TNF Therapy in Crohn’s Disease
Authors: Adegbola Samuel O. , Sahnan Kapil , Warusavitarne Janindra , Hart Ailsa , Tozer Philip
Published: August 2018

Crohn’s disease (CD) accounts for a variety of clinical manifestations or phenotypes that stem from chronic inflammation in the gastrointestinal tract. Its worldwide incidence is increasing including younger or childhood-onset of disease. The natural history of Crohn’s disease is characterized by a remitting and relapsing course that progresses to complications and surgery in most patients. The goals of treatment are to achieve clinical and endoscopic remission, to avoid disease progression and minimise surgical resections. Medical treatment usually features antibiotics, corticosteroids, immunomodulators (thiopurines, methotrexate). Anti-TNF (tumour necrosis factor) therapy was approved for use in Crohn’s disease in 1998, and has changed the paradigm of treatment, leading to improved rates of response and remission in patients. There are significant considerations that need to be borne in mind, when treating patients including immunogenicity, safety profile and duration of treatment.
Vitamin D in Neurological Diseases: A Rationale for a Pathogenic Impact
Authors: Moretti Rita , Morelli Maria Elisa , Caruso Paola
Published: August 2018

It is widely known that vitamin D receptors have been found in neurons and glial cells, and their highest expression is in the hippocampus, hypothalamus, thalamus and subcortical grey nuclei, and substantia nigra. Vitamin D helps the regulation of neurotrophin, neural differentiation, and maturation, through the control operation of growing factors synthesis (i.e., neural growth factor [NGF] and glial cell line-derived growth factor (GDNF), the trafficking of the septohippocampal pathway, and the control of the synthesis process of different neuromodulators (such as acetylcholine [Ach], dopamine [DA], and gamma-aminobutyric [GABA]). Based on these assumptions, we have written this review to summarize the potential role of vitamin D in neurological pathologies. This work could be titanic and the results might have been very fuzzy and even incoherent had we not conjectured to taper our first intentions and devoted our interests towards three mainstreams, demyelinating pathologies, vascular syndromes, and neurodegeneration. As a result of the lack of useful therapeutic options, apart from the disease-modifying strategies, the role of different risk factors should be investigated in neurology, as their correction may lead to the improvement of the cerebral conditions. We have explored the relationships between the gene-environmental influence and long-term vitamin D deficiency, as a risk factor for the development of different types of neurological disorders, along with the role and the rationale of therapeutic trials with vitamin D implementation.
Fluorescence Properties of a Novel Cyanobacteriochrome GAF Domain from Spirulina that Exhibits Moderate Dark Reversion
Authors: Wu Xian-Jun , Yang Hong , Sheng Yi , Zhu Yong-Li , Li Ping-Ping
Published: August 2018

Cyanobacteriochromes (CBCRs) are biliproteins for photoreception that are present in cyanobacteria. These proteins possess one or more unique cGMP-specific phosphodiesterase/adenylate cyclase/FhlA (GAF) domains that can covalently bind the linear tetrapyrrole (bilin). Light absorption triggers the photoisomerization of bilin between the 15Z and 15E photostates. The 15E photoproduct of some CBCR GAF domains can revert to the stable 15Z state in the absence of light. In some cases, this property makes these domains function as sensors of light intensity or as red/dark optogenetic switches. However, there have been few reports regarding the applicability of these fluorescent properties. Here, we report a red/green cyanobacteriochrome GAF domain from Spirulina subsalsa, designated SPI1085g3, which exhibited photoconversion from the red-absorbing dark state (Pr, λmax = 642 nm) to the orange-absorbing photoproduct state (Po, λmax = 590 nm), and exhibited moderate dark reversion (t1/2 = 3.3 min) from the Po state to the Pr state. The SPI1085g3 Pr state exhibited intense red fluorescence (λmax = 662 nm), with a quantum yield of 0.14. The fluorescence was switched off by red light irradiation and increased in the dark. Replacement of Cys448 of SPI1085g3 with Ser resulted in a slightly improved fluorescence quantum yield and nearly 13-fold faster dark reversion (t1/2 = 15.2 s) than that of the wild type. This novel red/dark-switchable fluorescent biliprotein expands the present repertoire and diversity of photoswitchable fluorescent protein candidates.
Effect of Doubled Sandblasting Process and Basic Simulated Body Fluid Treatment on Fabrication of Bioactive Stainless Steels
Authors: Yabutsuka Takeshi , Karashima Ryoki , Takai Shigeomi , Yao Takeshi
Published: August 2018

In our recent study, we aimed to impart hydroxyapatite (HA)-forming to bioinert stainless steels (SUS316L). The surfaces of SUS316L specimen were treated by a sandblasting process using alumina grinding particles with 14.0 or 3.0 μm for average particle size, respectively. In addition, a doubled sandblasting process (DSP) using the 14.0 μm particles and subsequently 3.0 μm ones were also conducted. Compared with the case of the 14.0 μm particles, the 3.0 μm particles were available to increase the surface roughness and the surface area of the specimen. Moreover, these values were further increased in the case of the DSP. These specimens were soaked in simulated body fluid (SBF) at pH = 8.4, 25 °C and were directly heated in the solution by electromagnetic induction. By this treatment, formation of CaP was induced on each specimen. These materials performed high HA-forming ability in SBF. Average bonding strength of the HA film formed on them in SBF was increased depending on the increase of surface roughness and surface area. These results indicated that sandblasting condition was an important factor to improve interlocking effect related to the increase of the surface roughness and the surface area.
Vibration Identification of Folded-MEMS Comb Drive Resonators
Authors: Han Jianxin , Li Lei , Jin Gang , Feng Jingjing , Li Baizhou , Jia Haili , Ma Wenkui
Published: August 2018

Natural frequency and frequency response are two important indicators for the performances of resonant microelectromechanical systems (MEMS) devices. This paper analytically and numerically investigates the vibration identification of the primary resonance of one type of folded-MEMS comb drive resonator. The governing equation of motion, considering structure and electrostatic nonlinearities, is firstly introduced. To overcome the shortcoming of frequency assumption in the literature, an improved theoretical solution procedure combined with the method of multiple scales and the homotopy concept is applied for primary resonance solutions in which frequency shift due to DC voltage is thoroughly considered. Through theoretical predictions and numerical results via the finite difference method and fourth-order Runge-Kutta simulation, we find that the primary frequency response actually includes low and high-energy branches when AC excitation is small enough. As AC excitation increases to a certain value, both branches intersect with each other. Then, based on the variation properties of frequency response branches, hardening and softening bending, and the ideal estimation of dynamic pull-in instability, a zoning diagram depicting extreme vibration amplitude versus DC voltage is then obtained that separates the dynamic response into five regions. Excellent agreements between the theoretical predictions and simulation results illustrate the effectiveness of the analyses.
Stretchability—The Metric for Stretchable Electrical Interconnects
Authors: Plovie Bart , Bossuyt Frederick , Vanfleteren Jan
Published: August 2018

Stretchable circuit technology, as the name implies, allows an electronic circuit to adapt to its surroundings by elongating when an external force is applied. Based on this, early authors proposed a straightforward metric: stretchability—the percentage length increase the circuit can survive while remaining functional. However, when comparing technologies, this metric is often unreliable as it is heavily design dependent. This paper aims to demonstrate this shortcoming and proposes a series of alternate methods to evaluate the performance of a stretchable interconnect. These methods consider circuit volume, material usage, and the reliability of the technology. This analysis is then expanded to the direct current (DC) resistance measurement performed on these stretchable interconnects. A simple dead reckoning approach is demonstrated to estimate the magnitude of these measurement errors on the final measurement.
Assessing Dietary Outcomes in Intervention Studies: Pitfalls, Strategies, and Research Needs
Authors: Kirkpatrick Sharon I. , Collins Clare E. , Keogh Ruth H. , Krebs-Smith Susan M. , Neuhouser Marian L. , Wallace Angela
Published: August 2018

To inform strategies to improve the dietary intakes of populations, robust evaluations of interventions are required. This paper is drawn from a workshop held at the International Society of Behavioral Nutrition and Physical Activity 2017 Annual Meeting, and highlights considerations and research priorities relevant to measuring dietary outcomes within intervention studies. Self-reported dietary data are typically relied upon in such studies, and it is recognized that these data are affected by random and systematic error. Additionally, differential error between intervention and comparison groups or pre- and post-intervention can be elicited by the intervention itself, for example, by creating greater awareness of eating or drinking occasions or the desire to appear compliant. Differential reporting can render the results of trials incorrect or inconclusive by leading to biased estimates and reduced statistical power. The development of strategies to address intervention-related biases requires developing a better understanding of the situations and population groups in which interventions are likely to elicit differential reporting and the extent of the bias. Also needed are efforts to expand the feasibility and applications of biomarkers to address intervention-related biases. In the meantime, researchers are encouraged to consider the potential for differential biases in dietary reporting in a given study, to choose tools carefully and take steps to minimize and/or measure factors such as social desirability biases that might contribute to differential reporting, and to consider the implications of differential reporting for study results.
A Polysaccharide Isolated from Dictyophora indusiata Promotes Recovery from Antibiotic-Driven Intestinal Dysbiosis and Improves Gut Epithelial Barrier Function in a Mouse Model
Authors: Kanwal Sadia , Joseph Thomson Patrick , Owusu Lawrence , Xiaomeng Ren , Meiqi Li , Yi Xin
Published: August 2018

Despite the tremendous biological activity of polysaccharides from the mushroom Dictyophora indusiata, its role in the restoration of gut microbiota has not yet been explored. The present study aimed to investigate whether D. indusiata polysaccharide (DIP) could modulate the recovery of gut microbiota composition and intestinal barrier function after broad-spectrum antibiotic-driven dysbiosis. Alteration and restoration in the microbial communities were elucidated by the Illumina MiSeq platform. Colon histology, expression of tight-junction associated proteins, and serum/tissue endotoxin and cytokine levels were evaluated. Two-week daily oral administration of clindamycin and metronidazole resulted in reduced bacterial diversity and richness, and perturbed the microbial flora at various taxonomic levels (altered Firmicutes/Bacteroidetes ratio and increased relative abundance of harmful flora (Proteobacteria, Enterococcus, and Bacteroides)), whereas DIP administration reversed the dysbiosis and increased beneficial flora, including Lactobacillaceae (lactic acid-producing bacteria), and Ruminococaceae (butyrate-producing bacteria). In addition, it resulted in the reduction of endotoxemia (through lipopolysaccharides (LPSs)) and pro-inflammatory cytokine (tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), and interleukin 1β (IL-1β)) levels, with the increased expression of tight-junction associated proteins (claudin-1, occludin, and zonula occludens-1). These findings not only suggested a comprehensive understanding of the protective effects of a DIP in the restoration of gut microbiota but also highlighted its role in the enhancement of gut barrier integrity, reduction of inflammation and lowering of endotoxin levels in mice.
A Methodologic Approach for the Selection of Bio-Resorbable Polymers in the Development of Medical Devices: The Case of Poly(l-lactide-co-ε-caprolactone)
Authors: Cingolani Alberto , Casalini Tommaso , Caimi Stefano , Klaue Antoine , Sponchioni Mattia , Rossi Filippo , Perale Giuseppe
Published: August 2018

In the last decades bioresorbable and biodegradable polymers have gained a very good reputation both in research and in industry thanks to their unique characteristics. They are able to ensure high performance and biocompatibility, at the same time avoiding post-healing surgical interventions for device removal. In the medical device industry, it is widely known that product formulation and manufacturing need to follow specific procedures in order to ensure both the proper mechanical properties and desired degradation profile. Moreover, the sterilization method is crucial and its impact on physical properties is generally underestimated. In this work we focused our attention on the effect of different terminal sterilization methods on two commercially available poly(l-lactide-co-ε-caprolactone) with equivalent chemical composition (70% PLA and 30% PCL) and relatively similar initial molecular weights, but different chain arrangements and crystallinity. Results obtained show that crystallinity plays a key role in helping preserve the narrow distribution of chains and, as a consequence, defined physical properties. These statements can be used as guidelines for a better choice of the most adequate biodegradable polymers in the production of resorbable medical devices.
A Phenology-Based Method to Map Cropping Patterns under a Wheat-Maize Rotation Using Remotely Sensed Time-Series Data
Authors: Liu Jianhong , Zhu Wenquan , Atzberger Clement , Zhao Anzhou , Pan Yaozhong , Huang Xin
Published: August 2018

Agricultural land use and cropping patterns are closely related to food production, soil degradation, water resource management, greenhouse gas emission, and regional climate alterations. Methods for reliable and cost-efficient mapping of cropping pattern, as well as their changes over space and time, are therefore urgently needed. To cope with this need, we developed a phenology-based method to map cropping patterns based on time-series of vegetation index data. The proposed method builds on the well-known ‘threshold model’ to retrieve phenological metrics. Values of four phenological parameters are used to identify crop seasons. Using a set of rules, the crop season information is translated into cropping pattern. To illustrate the method, cropping patterns were determined for three consecutive years (2008–2010) in the Henan province of China, where reliable validation data was available. Cropping patterns were derived using eight-day composite MODIS Enhanced Vegetation Index (EVI) data. Results show that the proposed method can achieve a satisfactory overall accuracy (~84%) in extracting cropping patterns. Interestingly, the accuracy obtained with our method based on MODIS EVI data was comparable with that from Landsat-5 TM image classification. We conclude that the proposed method for cropland and cropping pattern identification based on MODIS data offers a simple, yet reliable way to derive important land use information over large areas.
Does the Exhaustion of Resources Drive Land Use Changes? Evidence from the Influence of Coal Resources-Exhaustion on Coal Resources–Based Industry Land Use Changes
Authors: Wen Bo , Pan Yunhua , Zhang Yanyuan , Liu Jingjie , Xia Min
Published: August 2018

Analyzing the spatial-temporal changes of resources–based industrial land is essential to the transformation and development of resources–exhausted cities. In this paper, we studied coal resources–based industrial land use changes and their driving factors in a typical coal resources–exhausted city, Anyuan District, Pingxiang city. The changes between coal resources–based industrial land and other land-use types were analyzed. The logistic regression models were applied to identify the main driving factors and quantify their contributions to coal resources–based industrial land-use changes during the two periods of 2003–2008 and 2008–2013. The results show that coal resources–based industrial land declined by 34.37% during the period 2008–2013 as coal resources were being exhausted. Altitude, distance to roads, distance to town, population density change, fixed-asset investment per area change, and GDP per capita change drove coal resources–based industrial land-use changes. However, the patterns of the driving effects differed, and even the same factors had different influences on coal resources–based industrial land-use changes during the two periods. The changes in the driving factors can be seen as responses to socioeconomic transformation and development in the city, which is experiencing the exhaustion of coal resources. As a result of the comprehensive effects of these driving factors, coal resources–based industrial land use has changed in complex ways.
Research on the Disequilibrium Development of Output of Regional Innovation Based on R&D Personnel
Authors: Tian Xinbao , Wang Jiguang
Published: August 2018

Regional innovation is of great significance to the sustainable development of a regional economy. However, there exists a disequilibrium development of output of regional innovation in China, which affects the imbalance of regional economic development to a certain extent. In order to explore the process and mechanism of the disequilibrium development in regional innovation, a new perspective is adopted in this paper to analyze the index of R&D (research and development) personnel, which is an important input element of regional innovation output. The regional samples, including 31 provinces in China, are divided into three parts: eastern region, central region, and western region. First, developing the tendency and speed of the disequilibrium of regional innovation output are analyzed by using σ convergent model and β convergent model, respectively, during the period of analyzing the process of the disequilibrium development. Then, the LMDI (logarithmic mean Divisia index) method is used to analyze the character of regional innovation output by using R&D personnel as an important endogenous factor during the period of analyzing the mechanism of the disequilibrium development. At last, we draw the conclusion of the study. We find that: (i) there is a gap in the absolute amount between regions in a long term, but the gap between regions is shrinking and the speed of catching up between regions is different; (ii) the efficiency of R&D personnel is the most positive effect of promoting equilibrium.
Interval Fuzzy Segments
Authors: Jorba Lambert , Adillon Romà
Published: August 2018

In this paper, we bring together two concepts related to uncertainty and vagueness: fuzzy numbers and intervals. With them, we build a new structure whose elements we call interval fuzzy segments. We have undertaken this based on the conviction that the fuzzy numbers are a correct representation of the real numbers under situations of indeterminacy. We also believe that if it makes sense to consider the set of real numbers between two real bounds, then it also makes sense to consider the set of all the fuzzy numbers between two fuzzy number bounds. In this way, we extend the concept of real interval to the concept of interval fuzzy segment defined by two fuzzy bounds and a transition mapping that leads from the lower fuzzy bound to the upper fuzzy bound and this transition mapping generates the set of all the fuzzy numbers comprised between those fuzzy bounds. At the same time, this transition mapping brings the concept of interval fuzzy segment closer to the concept of line segment.
Botulinum Neurotoxin Diversity from a Gene-Centered View
Authors: Benoit Roger M.
Published: August 2018

Botulinum neurotoxins (BoNTs) rank amongst the most potent toxins known. The factors responsible for the emergence of the many known and yet unknown BoNT variants remain elusive. It also remains unclear why anaerobic bacteria that are widely distributed in our environment and normally do not pose a threat to humans, produce such deadly toxins. Even the possibility of accidental toxicity to humans has not been excluded. Here, I review the notion that BoNTs may have specifically evolved to target vertebrates. Considering the extremely complex molecular architecture of the toxins, which enables them to reach the bloodstream, to recognize and enter neurons, and to block neurotransmitter release, it seems highly unlikely that BoNT toxicity to vertebrates is a coincidence. The carcass–maggot cycle provides a plausible explanation for a natural role of the toxins: to enable mass reproduction of bacteria, spores, and toxins, using toxin-unaffected invertebrates, such as fly maggots, as the vectors. There is no clear correlation between toxigenicity and a selective advantage of clostridia in their natural habitat. Possibly, non-toxigenic strains profit from carcasses resulting from the action of toxigenic strains. Alternatively, a gene-centered view of toxin evolution would also explain this observation. Toxin-coding mobile genetic elements may have evolved as selfish genes, promoting their own propagation, similar to commensal viruses, using clostridia and other bacteria as the host. Research addressing the role of BoNTs in nature and the origin of toxin variability goes hand in hand with the identification of new toxin variants and the design of improved toxin variants for medical applications. These research directions may also reveal yet unknown natural antidotes against these extremely potent neurotoxins.
The tropical African genus Morgenia (Orthoptera, Tettigoniidae, Phaneropterinae) with emphasis on the spur at the mid tibia
Authors: Massa Bruno , Heller Klaus-Gerhard , Warchałowska-Śliwa Elżbieta , Moulin Nicolas
Published: August 2018

The authors revised the genus Morgenia Karsch, 1890 which now consists of eight species, of which three are here newly described (Morgeniaplurimaculata Massa & Moulin, sp. n., M.angustipinnata Massa, sp. n., and M.lehmannorum Heller & Massa, sp. n.). Six of the eight species occur in the Tri National Sangha (TNS) comprising Dzanga-Sangha Special Reserve and Dzanga Ndoki National Park (Central African Republic), whose high biodiversity has been recently highlighted. In particular the genus is characterised by the presence of a more or less long spur at the inner mid tibia, different in each species; in M.modulata, it moved lower down into a new position at about ¼ of tibia, which has a hollow underneath where the rest of the spur remains hidden. This is a unique known case in Phaneropterinae. Morphological characters distinguishing males of different species are presented. Bioacoustics of the new species M.lehmannorum are described. The patterns of the chromosome evolution in M.lehmannorum differ from other investigated African Phaneropterinae in terms of chromosome number and morphology, reduced ancestral chromosome number (2n = 25) implying a more derived condition.
About creation of the simulation model of the thermal mode in air cooling units for crude natural
Authors: Krasnov Andrey N.
Published: August 2018

Many Russian gas fields in the Arctic are now in the final development stage, so there is a need for additional gas compression along the gas collection system between the wells and the gas processing plant. After the compression stage, the gas is cooled in air cooling units (ACU). Cooling crude (wet) gas in low-temperature environments using ACUs involves a risk of hydrate plugs forming in the ACU’s heat transfer tubes. Variable frequency control of speed fans is typically used to control performance of the ACUs and the control criterion is the gas temperature at the ACU outlet. Even so, the chances of hydrate forming in the bottom of the tube bundle remain large owing to inhomogeneous distribution of the gas temperature in the tube bundles and the temperature jump between the inner surface of the tube wall and the gas flowing through that tube, despite the high gas temperature in the outlet header. To enable forecasting of possible hydrate formation, the mathematical model of the ACU’s thermal behaviour that forms the basis of control system’s operating procedure must ensure proper calculation not only of the gas temperature at ACU outlet but also the dew point at which condensate formation begins and the hydrate formation temperature. This article suggests a simulation model for crude gas ACU thermal behaviour that enables modelling of both the temperature pattern of the gas inside the tube and the areas of condensate and hydrate formation. The described thermal behaviour model may be used in ACU management systems.
Tapping into technology and the biodiversity informatics revolution: updated terrestrial mammal list of Angola, with new records from the Okavango Basin
Authors: Taylor Peter J. , Neef Götz , Keith Mark , Weier Sina , Monadjem Ara , Parker Daniel M.
Published: August 2018

Using various sources, including the Global Biodiversity Information Facility (GBIF), published literature, recent (2015–2017) collections, as well as bat detector and camera trap surveys with opportunistic sightings and live capture in the upper Okavango catchment in central Angola, we present an updated mammal checklist of 275 species from 15 different orders for Angola (including the Cabinda region). Recent surveys (captures and bat detectors) of small mammals from the upper Okavango catchment yielded 46 species (33 species of bats, ten species of rodents and three species of shrews). One bat (Pipistrellusrusticus, rusty pipistrelle); two rodents (Mussetzeri, Setzer’s mouse andZelotomyswoosnami, Woosnam’s broad-faced mouse) and one shrew (Suncusvarilla, lesser dwarf shrew) were captured for the first time, in Angola. While our species lists of bats conformed to predicted totals, terrestrial small mammals were under sampled, with only 13 species recorded by our trapping survey compared to a total of 42 shrew and rodent species expected based on GBIF records for the central Angolan highlands. Seven terrestrial small mammal species (one shrew and six rodents) are endemic to the central and western Angolan highlands but none of these were captured in our survey. The bat detector surveys added three further bat species to the country list:Pipistrellushesperidus,Kerivoulaargentata, andMopsmidas. Camera trap surveys and opportunistic sightings in the upper Okavango catchment in 2016 yielded a total of 35 species of medium-large mammals, from 17 families, although all of these had been reported previously in Angola. GBIF proved to be an excellent source of biodiversity data for Angolan mammals, most importantly for documenting dramatic historical range changes of larger mammals such as the sable (Hippotragusnigerniger), Kirk’s sable (H.nigerkirkii) and the giant sable (H.nigervariani).
What's in a Name? Revisiting Pilot Studies in Nursing Education Research
Authors: Spurlock Darrell R.
Published: August 2018

Pilot studies are a commonly described type of study in the nursing education literature. Although nursing education researchers continue to label small, single-site, hypothesis-driven studies as pilot studies, the consensus in other fields as to what constitutes a pilot study has changed over time to focus more narrowly on issues of feasibility and acceptability of study interventions and interactions. Nursing education researchers are encouraged to adopt more modern definitions of pilot studies that substantially reduce (or eliminate) the focus on inferential statistical testing while increasing the focus on practical and procedural aspects of study design and implementation. This article highlights the historical evolution of the term
pilot study
and provides researchers with suggestions about the purpose and focus of pilot studies that support development of the science of nursing education. [
J Nurs Educ.
2018;57(8):457–459.]
Development of an Innovative Endocrinology Training Program for Nurse Practitioners
Authors: Kreider Kathryn Evans , Padilla B. Iris
Published: August 2018

Background:

Nurse practitioners (NPs) have a critical role in meeting the growing demand for health care in the current complex health care system. The use of NPs in both primary care and specialty settings is expected to rise significantly by 2025 in response to increased demands and a shortage of physician providers.

Method:

The Duke University School of Nursing, with funding from the Health Resource Services Administration, has implemented the first endocrinology specialty training program for primary care NP students.

Results:

The first in the country, this innovative, hybrid training program prepares primary care NP students to manage complex diabetes mellitus and general endocrine conditions.

Conclusion:

Well-trained NPs can help meet the increased demands in primary care. This subspecialty certificate program provides a framework for other graduate nursing schools that are considering adding specialty content as a supplement to primary care training. [
J Nurs Educ.
2018;57(8):506–509.]
Thermo-Mechanical Behaviour of a Composite Stiffened Panel Undergoing the Tail-Pipe Fire Event
Authors: Riccio Aniello , Sellitto Andrea , Saputo Salvatore , Conte Giovanni , Zarrelli Mauro
Published: August 2018

In this paper, a numerical/experimental study is introduced on a carbon fibre reinforced polymer composite panel experiencing the tail-pipe fire phenomenon. This phenomenon, being of main concern for an Airplane during the engine-starting phase, can be qualitatively described as the ignition of a flame outside the nozzle impacting the adjacent aircraft structural components, such as the wing or the tail. The tail-pipe fire phenomenon is characterized by a variable duration and may cause the overheating or even the damage of the aircraft components. A numerical model, able to simulate the thermomechanical behaviour of composite structures under fire, is proposed. The presented approach, considering a strong coupling between the thermal and the structural fields and taking into account thermal and mechanical properties degradation, has been implemented in the commercial FEM software ABAQUS and applied to a stiffened composite panel. The numerical model has been validated by comparing the ABAQUS numerical results to the experimental data obtained by an ad-hoc campaign including mechanical tests under variable thermal conditions. The comparisons, performed in terms of Temperature-Time and Load-Strain evolution histories, showed a good agreement between numerical and experimental data, confirming the robustness of the proposed numerical tool and its effectiveness in predicting damage onset and propagation due to the presence of high thermal gradients.
Damage Assessment of Spinal Bones due to Prostate Cancer
Authors: Parra Sergio Andrés Ardila , González-Estrada Octavio Andrés , Quiroga Mendez Jabid E.
Published: August 2018

The present research proposes a methodology to determine the strength of a spinal bone in patients who suffer from prostate cancer using diagnostic imaging, with the purpose of verifying if metastasis has occurred, and critical conditions have been reached. Advanced numerical methods allow the modelling of anisotropic materials for different applications in biomedical engineering. The computed tomography images (CAT) provide the information to create a 3D model of the bone, in this case, the lumbar vertebra L5. Using segmentation software, it is possible to identify the mechanical properties of the materials that form the bone and define anisotropic conditions. The 3D anisotropic model is evaluated using finite element analysis (FEA), considering the appropriate boundary conditions and its respective material properties, and compared with the reference case of a healthy bone in an initial stage to assess the damage. Indicators based on the changes in stiffness of the vertebra could provide evidence of the need for chirurgical intervention.
Creep Damage Mechanisms in Cast Cobalt Superalloys for Applications in Glass Industry
Authors: Kvapilová Marie , Podhorná Božena , Dvořák Jiří , Král Petr , Zýka Jiří , Hrbáček Karel , Sklenička Václav
Published: August 2018

Two cast NbC and TaC- strengthened cobalt-base superalloys have been developed for a precision casting of spinner discs for glass wool industry. In the present study, the relationships between the type and morphology of carbides and the degradation processes in both types of cast cobalt-based superalloys subjected to high temperature creep have been examined. It was found that the nature of carbides within the alloy microstructure plays a critical role in determining the creep damage processes and microstructure stability of the alloy system under high temperature creep. The morphology of the carbides is a strong function of their chemical composition. The interface decohesion between the complex carbides and the matrix and cracking of the brittle carbides homogeneously distributed in the crept NbC - strengthened alloy lead to brittle intergranular and/or interdendritic fracture. By contrast, Ta - strengthened alloy exhibited very small extent of isolated creep damage and the final fracture is ductile transgranular mode.
Investigation of Integral Composite T-Joints under Mixed Mode Loading
Authors: Nolte Felix , Hannig André , Horst Peter
Published: August 2018

This paper presents experimental and numerical results on the deformations and failureof integral composite T-joints subjected to a realistic combined tensile and bending (mixed mode)load case. For this reason, standard pull-off and mixed mode load cases are experimentally studiedby means of a novel test fixture which keeps the force angle constant to the T-joint’s base and allowsfor repositioning of the specimen in order to minimize constraining forces. Two types of specimenswith varying deltoid radius are investigated. Additionally, kinematically nonlinear numerical simulationsare performed to locate damage onset and deformations of the specimens. It is found that thesimulations are in good agreement with the experimental results.
Modeling, Simulation, and Experimentation of Fatigue Behavior in Amorphous Solids
Authors: Barriere Thierry , Cheng Gang , Holopainen Sami
Published: August 2018

Amorphous solids, such as certain polymers, alloys, and polymer-based composites,are increasingly used materials in engineering components and thus, their fatigue behavioris of utmost importance. The article presents a unified approach suitable for modeling bothisothermal high cycle and low cycle fatigue behavior. The emphasis is placed on the ductilefatigue in which fatigue damage represents the material degeneration during the creation ofmicro-cracks governing majority of the total fatigue life (up to 95%). The model’s capability fortechnologically important polycarbonate (PC) polymer is addressed. The results, in accordancewith experimental observations, favor ductile fatigue behavior, i.e. damage fields remain smallfor most of the fatigue life and do not cause the macroscopic stress reduction. Due to thisproperty, fatigue life of an entire structural element can be evaluated by exploiting singlelocations at which the fatigue damage decisively emerges.