bluuebunny/crossref_metadata_2025 huggingface dataset:
Media Discourse on the Kashmir Conflict after Abrogation of Article 370
Authors: Siddiqua Ayesha , Iqbal Muhammad Zubair , Iqbal Muhammad Zubair
Published: January 2024

The study tries to unfold how the Kashmir conflict is constructed in the Pakistani media after the abrogation of Article 370 of the Indian Constitution. To understand the media discourse a Critical discourse analysis of the news stories published about Indian held Kashmir (i.e. that part of the former princely state of Jammu and Kashmir occupied by India post the 1947 partition, notably the valley of Kashmir) in the e-paper of Dawn was carried out. The findings reveal a distinctive narrative strategy employed by Pakistani media in response to the abrogation of Article 370. This strategy accentuates the negative aspects of the Indian government's actions in Kashmir while simultaneously highlighting the voices of Kashmiris advocating for their right of self-determination. The findings also indicated that media discourse revolved around challenging the legitimacy of the Indian Parliament’s act of abrogating Article 370 and also focused on the casualties and losses which took place as a result of clashes between the Indian security forces and the Kashmiri separatist fighters. The media also gave significance to social media trends about Indian held Kashmir and also to posts of Kashmiri and Pakistani politicians. Negative actor description was used to highlight Bharatiya Janata Party (BJP)’s propaganda regarding the return of normalcy in the Indian held Kashmir whereas positive actor description was used for the Kashmiri separatist fighters.
نسق المصطلحات الصرفية في كتاب (مبتدأ الكشف في علم الصرف) لناصر بن أبي نبهان الخروصي
Authors: بن سليمان الريامي محمود
Published: January 2024

تنطلق دراسة (نسق المصطلحات الصرفية في كتاب (مبتدأ الكشف في علم الصرف) لناصر بن أبي نبهان الخروصي) من اعتبار أن البناء المصطلحي جهاز مفهومي يضع تصورا واضحا للبناء الداخلي للعلم الذي يعبّر عن مقولاته. وهي دراسة تفحص هذا القضية في كتاب الخروصي، بسبرها لثلاث قضايا هي: المصطلحات الصرفية التي أوردها في كتابه، وكيفية عرض المصطلحات المفردة والمركبة، وطرق شرح هذا المصطلحات، وقد اعتمدت الدراسة التقسيم الثلاثي لأنواع الكلام من اسم أو فعل أو حرف؛ باعتبارها أصول التقسيم لنسق علم الصرف ومصطلحاته التي تتفرع عنها القضايا وتعبر عن مفاهيمها المصطلحات مفردة أو مركبة. وخلصت الدراسة إلى أن الخروصي كان واعيا وعيا تاما بالبناء النسقي لعلم الصرف ولمصطلحاته المعبرة عن مفاهيمه، وقد عالج في كتابه هذا قضايا تصريف الأفعال والمشتقات دون باقي القضايا الصرفية، وكان لا يخرج في اصطلاحه عن منهج تيسير الصرف، كما ذكر الأصول التي يمكن القياس عليها، واهتم بضبط الحدود المفهومية للمصطلحات الأساسية كالاسم والفعل والحرف، وأكثر من ذكر المصطلحات المركبة التي تدل على مفاهيم النسق الاصطلاحي الصرفي، وقد يختصر المصطلح في عبارة مفردة دالة على موقعها من النسق، وكما أنه شرح كثيرا المصطلحات بالتمثيل وغيره

الكلمات المفتاحية: نسق؛ مصطلح؛ علم الصرف؛ ناصر بن أبي نبهات الخروصي؛  كتاب مبتدأ الكشف في علم الصرف.
الحق في المساواة بين العُمال في قضاء المحكمة العليا العمانية – تعليق على الحكم رقم 157/2015، الصادر عن الدائرة العُمالية – جلسة الاثنين، الموافق 20/11/2015م
Authors: بن جمعة المسكري بدر , بن حمود النظيري راشد
Published: January 2024

تهدف هذه الدراسة إلى التعليق على حكم صادر من المحكمة العليا العُمانية، يقرر مبدأ المساواة بين العمال إذا اتحدت مؤهلاتهم، واتفقت كفاءاتهم في ظلال العمل الواحد، تحت ظروف واحدة، بغية تحقيق هدف مشترك واحد، ولذلك بيَّنت الدراسة المبدأ التي أرسته المحكمة العليا، ووقائع الدعوى التي أُسِّس عليها المبدأ، والدفوع المقدمة من أطراف الدعوى ثم الحُكم الذي قضت به المحكمة، والذي ابتغت به تحقيق مبدأ المساواة وفق قانون العمل العُماني. ثم تعرضت الدراسة لمكانة مبدأ المساواة بين الأشخاص وأهميته، وكيف لم تغفل عنه الاتفاقيات الدولية، والإعلان العالمي لحقوق الإنسان والنظام الأساسي للدولة في سلطنة عُمان؟ إلا أنه مبدأ نسبي تكتنفه أحوال، وتعتريه ظروف قد تحوله إلى طغيان وظلم. ولذلك وقفت الدراسة على بيان مفهوم مبدأ المساواة وتأصيله، ومتى يحقق العدالة، التي تُعد مطلبا إنسانيا وشرعيا وقانونيا؟ مع تأييد ذلك بأمثلة تطبيقية عملية، قضى بها الشرع الإسلامي، أو أخذ بها قانون العمل العُماني. كما أشارت الدراسة إلى الآثار المترتبة على اختلاف آلية شغل العمل بين العمال على مبدأ المساواة، ثم إظهار الفرق بين العقد الجبري الذي لا خيار فيه والعقد القائم على تمام الرضا والاختيار، وعلاقة ذلك بمبدأ المساواة الذي يحقق العدالة المنشودة. وختمت الدراسة بمجموعة من النتائج والتوصيات، التي يدعو الباحثان إلى الأخذ بها.

الكلمات المفتاحية: مبدأ؛ المساواة؛ المحكمة؛ العمل؛ العُمَّال.
THE INFLUENCE OF A COGNITIVE-BEHAVIORAL COUNSELLING PROGRAM ON MARITAL ADJUSTMENT IN SUDAN
Authors: Dafa Allah Ahmed Abdelbagi , Elbalola Hasona Aisha
Published: January 2024

This study aims to examine the effects of a cognitive behavioral therapy counseling program on couples' adjustment and their relationship to variables such as their marital status, age, and number of children. In a semi-experimental design, a purposive sampling procedure was used to select a sample of ten couples attended counseling centers in Khartoum State who ranged in age from 20 to 50 years.  T-tests, Cronbach's alpha, and Pearson's correlation coefficients in SPSS were used to analyze data collected by the basic information sheet, marital adjustment scale, and counseling program. Based on the study's most important findings, the program proved significantly effective at improving marital adjustment, and there was no significant correlation between its effectiveness and the length of the marriage, age, or number of children of the couples. As a result, it can be applied to couples of any age or marital status as well as couples with different numbers of children and marital durations. To minimize marriage problems and reduce the sensitivity or reluctance to visit counseling centers, the researcher recommends raising society's awareness about the importance of attending counseling centers.

Keywords: Marital problems; Self-concept; Positive communication; Sudanese couples; Adjustment.
HUBUNGAN SINDROM LANSIA LEMAH DENGAN KUALITAS HIDUP LANSIA
Authors: Riani Pradara Jati  , Rina Anggraeni  , Dian Lestari
Published: January 2024

Lansia umumnya mengalami banyak masalah biologis maupun psikologis. Terdapat sindrom pada lansia lemah. Sindrom lansia lemah dapat berpengaruh terhadap kualitas hidup lansia. Kualitas hidup merupakan suatu konsep yang sangat luas yang dipengaruhi oleh kondisi fisik individu, psikologis, tingkat kemandirian, serta hubungan individu dengan lingkungan. Metode: Penelitian ini bertujuan mengidentifikasi hubungan sindrom lansia lemah dengan kualitas hidup lansia. Desain penelitian ini deskriptif korelatif cross-sectional, dengan jumlah sampel 201 lansia yang dipilih menggunakan teknik proportionate random sampling.Analisis data menggunakan uji statistik spearman. Hasil: Ada hubungan sindrom lansia lemah dengan kualitas hidup lansia (p value 0,004). Diskusi: Salah satu cara meminimalisir munculnya penyakit-penyakit degeneratif pada lansia adalah dengan memotivasi agar lansia menjaga kesehatan fisik maupun psikologis supaya mempunyai kualitas hidup yang baik.
MENINGKATKAN EFEKTIVITAS PENGGUNAAN MEDIA SOSIAL PADA MAHASISWA DAN HUBUNGANNYA DENGAN BISNIS ONLINE
Authors: Cut Puspita  , Marisa Anggraini  , Ainun Salsabila  , Bagus Kusuma Wardhana  , Budiandru Budiandru
Published: January 2024

Penelitian ini bertujuan untuk mengetahui bagaimana efektifitas penggunaan sosial media dikalangan mahasiswa terhadap bisnis online. Metode penelitian yang digunakan adalah metode kuantitatif dengan menyebarkan kuesioner ke 40 mahasiswa FKIP UHAMKA. Berdasarkan analisis regresi, diperoleh hasil nilai signifikansi sebesar 0.072 atau nilai kurang dari 0.05. Dengan demikian, dapat disimpulkan bahwa H0 ditolak dan H1 diterima. Artinya, terdapat pengaruh antara efektivitas penggunaan sosial media terhadap bisnis online. Efektivitas penggunaan sosial media memberikan pengaruh terhadap bisnis online. Efektivitas penggunaan sosial media memberikan pengaruh terhadap bisnis online. Dan dari data yang sudah diolah dapat disimpulkan bahwa efektivitas penggunaan sosial media terhadap bisnis online sebesar 83% sementara 28,8 % lainnya dipengaruhi oleh variabel lain diluar penelitian ini.
PRINSIP KEJUJURAN DALAM JUAL BELI MENURUT PERSPEKTIF AL-QUR’AN
Authors: Citra Andanari. M  , Achmad Abubakar  , Halimah Basri
Published: January 2024

Konsep perdagangan dalam islam harus dilandasi oleh nilai-nilai dan etika yang bersumber dari nilai-nilai dasar agama yang menjunjung tinggi kejujuran dan keadilan. Nabi telah meletakkan prinsip dasar bagaimana pelaksanaan perdagangan yang adil dan jujur. Prinsip dasar yang digariskan oleh Nabi berkaitan dengan mekanisme pasar dalam perdagangan, dimana kedua belah pihak dapat menjual dan membeli barang secara langsung sehingga tidak ada campur tangan dan campur tangan pihak lain dalam menentukan harga barang. Dengan kejujuran diharapkan usaha dagang seorang muslim akan semakin maju dan berkembang, karena akan diridhoi Allah di dunia dan di akhirat.
WACANA DIALOG KEAGAMAAN DALAM PLURALISME (SUATU TINJAUAN HERMENEUTIKA HANS-GEORG GADAMER)
Authors: Hariyanto Hariyanto
Published: January 2024

Keberagamaan merupakan sesuatu yang tidak mungkin bisa dihindari, keberagaman menghasilkan warna dalam realitas sosial, tetapi keberagaman juga sering menimbulkan pertikaian, konflik. Walapun demikian usaha menciptakan kembali perdamaian, kerukunan sesuai kalam Tuhan merupakan tugas yang harus dilaksanakan oleh manusia sebagai umat yang berakal. Pluralisme lahir dengan wacana dialog antar agama merupakan sarana mewujudkan keharmonisan, kerukunan, mengurangi egoistik, fanatik dalam beragama demi menghindari konflik yang tak berkesudahan atas nama agama. tulisan ini akan membedah wacana dialog keagamaan dalam pluralisme dengan pisau analisis hermeneutika Gadamer yaitu teori dialektika teks, yakni berupaya demi mencari makna yang diinginkan oleh teks dengan proses dialog.
Identification and characterization of some phytopathogenic fungi in post-harvest potato (Solanum tuberosum) in the El Oued Region (Eastern Northern Sahara, Eastern Algeria)
Authors: Benhaoued Fatma Zohra , Bissati-Bouafia Samia , Hadjadj Soumia , Hammoudi Roukia
Published: January 2024

The global staple crop, the potato (Solanum tuberosum L.), is susceptible to post-harvest rot caused by various fungal pathogens.These pathogens lead to a significant reduction in potato quality and marketable yield. Our study aimed to isolate and identify different phytopathogenic fungi present on potato tubers after harvest in the El Oued region of Eastern Sahara, Algeria. We utilized Potato’s Dextrose Agar (PDA) culture medium for isolating and identifying molds. Macroscopic examination was performed with the naked eye and under a binocular microscope. Microscopic examination allowed us to determine certain morphological characteristics such as spore type and thallus shape. Total genomic DNA was extracted from seven-day-old cultures using a commercial NucleoSpin Plant II kit.Based on morphological features and molecular analyses of spore isolates, using nucleotide sequences from the internal transcribed spacer (ITS), the results of 18S rDNA analysis confirmed that the fungi infesting the tubers were identified as Fusarium proliferatum, Alternaria alternaria, Rhizoctonia solani, and Wickerhamomyces anomalus. This study represents the first report of Fusarum proliferatum,Alternaria alternate,Rhizooctonia solani and wickerhamommces anomalus causing wilt diseases, dry rot, Canker and black scurf of potato tubers in southern Algeria.
Update Knowledge: Persiapan Lingkungan Rumah Sakit Dalam Menyongsong Akreditasi JCI (Joint Comission International) Dalam Ranah Keselamatan Pasien di Rumah Sakit di Kabupaten Salatiga
Authors: Anggraini Anggi Napida , Kur'aini Sri Nurul , Prasastin Oliva Virvizat , Krisdianto Muhammad agung
Published: January 2024

Di Indonesia, mayoritas rumah sakit terakreditasi nasional SNARS, namun saat ini beberapa rumah sakit sudah mulai mempersiapkan rumah sakit agar dapat terakreditasi lebih dari itu, yaitu Joint Commision International (JCI). Rumah sakit dengan giat mencari informasi dan mulai mempersiapkan untuk pelaksanaan JCI di rumah sakitnya. Umumnya, rumah sakit melaksanakan keselamatan pasien saja. Untuk dapat melakukan perbaikan berkelanjutan perlu adanya evaluasi dari pelaksanaan keselamatan pasien yang sedang berjalan saat ini hingga analisis persiapan lingkungan RS berdasarkan indikator akreditasi JCI (Joint Comission International). Pengabdian masyarakat ini berfokus kepada meningkatkan pengetahuan tenaga kesehatan tentang persiapan lingkungan rumah sakit dalam menyongsong Akreditasi JCI (Joint Comission International) dalam ranah keselamatan pasien Di rumah sakit di kabupaten Salatiga. Tingkat pengetahuan peserta tentang persiapan lingkungan rumah sakit dalam menyongsong akreditasi JCI (joint comission international) dalam ranah keselamatan pasien ini mengalami peningkatan menjadi baik sebesar 90%. terdapat perbedaan sebelum dan sesudah penyuluhan setelah dilakukan uji menggunakan Uji Paired Sample T-Test. Dari hasil uji tersebut, didapatkan nilai p-value sebesar 0,000 (p<0,05) yang artinya hasil ini menunjukkan adanya perbedaan yang signifikan antara pengetahuan peserta sebelum dan sesudah diberikan penyuluhan. Jadi dapat disimpulkan bahwa dengan adanya kegiatan pengabdian kepada masyarakat ini menambah tingkat pengetahuan peserta tentang persiapan lingkungan rumah sakit dalam menyongsong akreditasi JCI (joint comission international) dalam ranah keselamatan pasien.
Kata Kunci: Joint Comission International, Akreditasi Rumah Sakit
Investigation on Safety Problems and Risk Prevention of College Students' Sports Activities
Authors: Huang Xiaodong
Published: January 2024

Recent years, the country has placed sports in an important strategic position for development, and put forward red documents such as Quanming Fitness and Sports Power, which shows the important influence of sports on national nations. Under the background of the new era, especially the contemporary college students, their physical quality and cultural accomplishment play an extremely important role in the development of the Chinese Dream. Sports can strengthen muscles, bones, knowledge and will. The vigorous development of sports plays a positive role in promoting the country. The great rejuvenation of the Chinese nation is inseparable from the development of the national physique.The research object of this paper is the safety problems and risk prevention in college students' sports. The research methods are literature, expert interview, questionnaire survey and mathematical analysis to get the source of the problems and make some suggestions. At present, the safety problems of College Students' Sports emerge in endlessly, the risk accidents increase sharply, and the problems are not properly handled. College students love sports activities, but their safety awareness is weak. Sports injuries are mostly caused by personal reasons, followed by sports facilities.Most of the injured parts occur in the joints, and the body recovery after exercise is improper. It is necessary for students to strengthen the awareness of sports safety accidents, and schools should also pay attention to training students' safety knowledge and improving equipment. As for the safety problems at this stage, it is inevitable for schools to participate in sports insurance, which can not only properly deal with students' sports safety accidents.
The Function of Humanities Education in Russian Language at University
Authors: Su Wei
Published: January 2024

Humanities education emphasizes humanistic education, aims at perfecting personality, and focuses on achieving and promoting the harmonious development of individual body and mind. Humanities education in universities is mainly embodied in general education courses, but specialized courses education also plays a non-negligible and irreplaceable role in cultivating humanities education for college students. In this paper, we explore the functions of specialized Russian courses in disseminating humanistic knowledge, enlightening humanistic thoughts, cultivating humanistic spirit and shaping a sound personality from the perspective of university Russian education, and discuss the qualities that teachers should possess and the role they should play in it.
Meta-cognitive Strategies, Automated Writing Evaluation Feedback and English Writing Performance of Chinese EFL College Students
Authors: Feng Zhe
Published: January 2024

The research aimed to assess the associations among the implementation of meta-cognitive strategies, the support of automated writing evaluation feedback system and the English writing performance of Chinese EFL college students. The findings of the research indicated that incorporating meta-cognitive strategies during the writing process and utilizing automated writing evaluation feedback significantly contributed to the enhancement of English writing skills among students. A majority of the respondents reported actively employing various meta-cognitive strategies while writing and receiving substantial knowledge, intellectual, and emotional support through automatic writing evaluation feedback, resulting in noticeable improvements in their writing abilities. This study offers English administrators and teachers’ valuable insights that can help foster English language proficiency among Chinese EFL college students. Furthermore, the study recommended that future research should explore additional challenges and concerns related to English writing for EFL college students, providing opportunities for academics to delve deeper into this area.
Study on Achievement Goal Orientation and English Learning Motivation of Vocational College Students
Authors: Dong Yijun
Published: January 2024

The achievement goal orientation theory is applicable to explaining the relationship between student learning motivation and their level of effort. Vocational college students have poor English foundation and low motivation to learn English. Teachers can cultivate students' positive achievement goal orientation and improve their English proficiency through four strategies: adjusting teaching objectives, adopting encouraging evaluations, designing reasonable teaching methods, and supplementing teaching content.
Research on Innovation of International Training Path of Hotel Management in Zhejiang Higher Vocational Colleges
Authors: Ding Wei , Xiao Pengwei , Dai Xinqian , Yan Qianhao , Zhao Leyu , Wang Tao
Published: January 2024

This paper aims to explore and innovate the international training path of hotel management in Zhejiang higher vocational colleges. The research background emphasizes the challenges that Zhejiang Province, as a frontier region of China's economy, faces in the internationalization of hotel management education, and provides theoretical basis and practical guidance through the synthesis of domestic and foreign literature. The core goal of the research is to comprehensively improve the international education level of the profession and develop effective strategies to enhance students' internationalization ability. Through the use of multi-dimensional analysis and a variety of research methods, including literature research, questionnaire survey, case study and interview, the research deeply discusses the goal, content, approach, effect and quality of internationalization education, as well as countermeasures and suggestions. Special emphasis is placed on the innovation of curriculum setting, teaching mode and integration of international resources. This study provides comprehensive theoretical support and practical guidance for the internationalization training of hotel management majors in Zhejiang vocational colleges, aiming at improving the quality of education and international competitiveness of students, and contributing to the sustainable development of local tourism industry.
An improved Approach for Sustainable Risk Management Practices in Modern Businesses
Authors:   American University in the Emirates, Dubai, UAE, Abualkishik Abedallah Z. ,   American University in the Emirates, Dubai, UAE, Almajed Rasha
Published: January 2024

The complexity of the business environment, which is shaped by dynamic economic, environmental, and social factors, makes it more important for companies to develop sustainable risk management practices. This research proposes a novel approach that combines traditional methods with modern machine learning techniques in response to the complex challenges faced by contemporary businesses in balancing risk and sustainability. Our study uses a public bank loan default dataset as a case study to address missing data systematically through robust imputation mechanisms and transform categorical variables using feature encoding. Spearman correlation analysis helps us understand complex variable relationships and guides subsequent feature selection. The decision tree classifier, a powerful machine learning algorithm known for its interpretability, is applied to identify key factors contributing to risk assessment. The hierarchical structure of the decision tree not only reveals important variables but also provides an explicit representation of the decision-making process. ROC curve analysis shows how well our predictive model can differentiate potential loan defaults.
Efficient Data Fusion Framework for Real-Time Monitoring of Air Pressure Systems in Scania Trucks
Authors:   Department of International Business Management, Tashkent State University of Economics, Uzbekistan, Bakhodirova Durdona
Published: January 2024

Monitoring air pressure systems in heavy-duty vehicles such as Scania trucks is a key driver for operational safety and efficiency in the automotive industry. However, the complex interaction of sensors and data sources makes it difficult to quickly detect potential system failures. This problem is solved in our paper where we present a special-purpose data fusion framework for real-time monitoring of Scania trucks’ air pressure systems. To achieve this, PCA is used to reduce the size of the dataset followed by a voting classifier which combines diverse models such as Decision Trees, Random Forests, Naive Bayes, and Linear Regression using ensemble learning. In particular, our comparative analysis shows that the Voting Classifier outperforms other ML methods in terms of prediction accuracy. These findings suggest that our fusion framework can be utilized for the early detection of air pressure anomalies in heavy-duty vehicles enhancing their safety record.
Immune checkpoint inhibitor combination therapy
Authors: Liu Xiaoying
Published: January 2024

In recent years, Immune checkpoint inhibitors (ICIs) are being approved for the treatment of a wide range of malignancies, and they are one of the most popular immunotherapies for tumours, bringing new hope to patients. However, single-agent ICI therapy has limited efficacy and is prone to drug resistance, and the objective remission rate of ICI alone is only 10-20% in some tumours, therefore, how to improve clinical efficacy is the key point of clinical research associated with immunotherapy. New research has found that the combination of ICIs with differing mechanisms not only improves efficacy, but also prolongs the anti-tumour effect, while an appropriate dosing regimen can effectively balance efficacy and safety. It is proposed to review the mechanism, pharmacokinetics and clinical research progress of ICI combination therapy.
Improving brain penetration using elacridara P-glycoprotein and BCRP inhibitor
Authors: Yao Xinyue
Published: January 2024

The central nervous system (CNS) is a site for a myriad of disorders and diseases, such as schizophrenia, Alzheimers disease, and Parkinsons disease. Many medications targeting these illnesses remain challenged due to efflux transporters forming a blood-brain barrier (BBB). To combat such challenges, elacridar shown promise at inhibiting such transporters, such as P-glycoprotein (P-gp) and breast cancer resistance protein (BCRP), therefore improving brain penetration. However, as an early clinical candidate, many remain unknown about elacridars pharmacokinetic (PK) properties in the human body. This paper aims to obtain a better understanding of elacridars pharmacokinetic profile and predict the optimal dose and dose interval for its application in the clinic. To begin with, a series of basic PK models were created using fundamental PK equations and the models were fit to elacridar clinical data to obtain elacridar-specific PK parameters. Next, elacridar preclinical PK as well as in vitro inhibition assay were used to determine the therapeutic window. Our final, multiple-dose extravascular PK model reveals that the most convenient and effective dose regimen is 900 mg BID (bis in die; twice per day). With this elacridar PK model, researchers can leverage elacridar human PK to improve clinical outcomes.
The potential and prospects of sleep biomarkers in early Alzheimer's disease diagnosis
Authors: Li Xiuyun
Published: January 2024

Alzheimers disease (AD), often accompanied by sleep disturbances, is a neurodegenerative disease. Sleep disruptions have the potential to serve as biomarkers for early diagnosis because they can be observed in the initial stages of disease progression in the sleep-wake cycle. This paper summarizes the latest findings on AD manifestations during non-rapid eye movement (NREM) sleep, rapid eye movement (REM) sleep, sleep oscillations, and cognitive impairment. It provides a detailed overview of diagnostic bioindicators for primary Alzheimers disease, including invasive cerebrospinal fluid (CSF) markers, non-invasive electroencephalography (EEG), and plasma biomarkers, and compares their advantages and limitations in diagnosing early AD. The accuracy and reliability of sleep biomarkers in early diagnosis are evaluated, along with their clinical application prospects. The paper also proposes improvements in the use of sleep clinical markers for early Alzheimers disease diagnosis, aiming for greater breakthroughs in this field. The significance of this review lies in its in-depth exploration of the association between sleep disturbances and the early period of the disease, along with the introduction of potential biomarkers that can serve as tools for early determining and monitoring of this neurodegenerative health issue.
Cyclin D1 in various cancers: Mechanisms and clinical implications
Authors: Zhao Wuwei
Published: January 2024

Gastrointestinal cancers, including esophageal, gastric, hepatic, pancreatic, and colorectal malignancies, present a significant global health challenge. Their distinct characteristics characterized by abnormal cell proliferation, invasive behavior, and tumor formation make them highly aggressive and detrimental to human health. These diseases often lead to malnutrition, organ failure, and obstruction. Cyclin D1 protein is a critical regulator of cell cycle progression and an essential marker for comprehending the complex landscape of cancer biology. This research provides an in-depth exploration of gastrointestinal cancers by shedding light on their adverse effects on the human body while emphasizing the critical role played by cyclin D1 within this challenging disease context. Extensively studied in colorectal cancer as well as esophageal squamous cell carcinoma (ESCC), gastric cancer, and pancreatic cancer contexts. Cyclin D1 emerges as a key player. Specifically, in cases of colorectal cancer, overexpression of cyclin D1 is frequently linked to aggressive tumor behavior brought on by APC gene mutations and abnormal Wnt signalling pathway activation. Esophageal cancer patients especially those with ESCC frequently exhibit elevated levels of Cyclin D1 indicating poor prognosis. A similar trend is observed in gastric cancer where increased expression of cyclin D1 is linked to disease severity.
Gut-to-brain axis provides novel therapeutic targets for depression
Authors: Xu Yixin
Published: January 2024

As an essential counterpart of the human internal environment, the gut microbiome has been investigated extensively in light of multiple diseases. This study aims to find out potential treatments for depression by altering gut microbiome composition in order to alleviate side effects caused by traditional medications. According to previous findings, the human gut correlates with the brain through pathways known as the gut-brain axis. Two genera of microbiome, Lactobacillus and Bifidobacterium, have been mentioned by researchers to be crucial to depression-related neurotransmitter secretion in GBA. Besides, they have already been used in clinical as effective probiotics for gut-related diseases. The paper hypothesized particular interactions between the two genera and the human nerve that enable them to be therapeutic cures in adequate amounts. In this study, a range of available single-cell data about depression and lactobacillus and bifidobacterium were analyzed and adjusted into proper figures. I discuss the efficacy of different species, concentrations, and other elements of those probiotics, eventually proposing a novel way of treating and classifying depressive disorders. The study puts forth a perspective of maintaining a depression-free state with an internal factor, the gut microbiome, instead of targeting the efferent neurons directly with external drugs which could cause resistance and severe side effects.
Analysis of the current status and development prospects of artificial hearts
Authors: Yuan Yuan
Published: January 2024

Confronted with the rapid need for transplantable hearts, patients who need a heart transplant cannot receive the suitable configuration. Thus contributes to the development of artificial hearts, which can be created to substitute the old, the ill heart without waiting for transplantable hearts. Nowadays, this paper shows the public the artificial hearts. Through the extensive literature, it is clear that the development of artificial hearts. Dating back to the fifties of the last century, scientists began studying artificial hearts. Till now, China has created four generations of artificial hearts. They became more and more strong. The importance of the heart goes without saying, however, every year there are more and more heart failure patients. Paying more attention to the artificial hearts helps reduce the death rate of heart failures. Actually, although the patients can get the heart donors, they may not tolerate rejection. So research into artificial hearts more suitable for patients is imminent. This paper mainly introduces the fourth-generation artificial hearts (in fact, it is an improved version of the third generation), the magnetic levitation artificial heart attracts much more attention, and its composition and function have been greatly improved, reducing the difficulty of surgery. It is hoped that people can know much more about artificial hearts, and prospects for better methods to make better artificial hearts, and promote heart transplantations.
Childhood trauma and major depression in Chinese college students: mediating role of Internet addiction and victimization of domestic violence
Authors: Wang ZeZheng
Published: January 2024

Aim: Major depression disorder in adolescents has received much attention around the world. While the factors correlated with major depression in adolescents have been extensively described, the mechanisms underlying the complexity of the relationship between childhood traumatic experiences and major depression have been less studied. This study investigated both the direct influence of childhood trauma on major depression and whether the mediation of domestic violence victimization and Internet addiction played a role in connecting childhood trauma to major depression. Method: The school-based mental health survey was conducted in April 2023 in northeast Chinas Heilongjiang Province. We collected sociodemographic information and targeted mental health outcomes with standardized questionnaires. Hierarchical multiple logistic regression and structural equation modeling were used to analyze the data. Results: The study included 596 college students. The prevalence of major depression and Internet addiction was 31.2% and 21.6%, respectively. 16.4% of participants reported experiences of childhood trauma and 12.8% reported being victims of domestic violence. Childhood trauma, domestic violence victimization and Internet addiction have direct effects on major depression. The total effect of childhood trauma on suicidal ideation was 0.201 (p < 0.001). Domestic violence victimization and Internet addiction play mediating roles between childhood trauma and depression. Internet addiction plays a mediating role between domestic violence and major depression. Childhood trauma has direct and indirect effects on major depression of college students. Domestic violence victimization and Internet addiction play mediating roles in major depression of college students. Understanding these relationships will help develop and implement more targeted interventions and strategies to improve the mental health of Chinese college students.
Research on the effects of extreme heat exposure on human health
Authors: Li Menghan
Published: January 2024

Nowadays, more and more studies indicate that heat exposure negatively affects human health. As climate change and global warming increased, extreme heat exposure became more rigorous and killed mountains of people every year. Extreme heat is not only a threat to physical health but also to mental health. Epidemiological studies have shown that heat waves can increase peoples morbidity and mortality. This literature review will discuss in detail the impact of extreme heat on human health, and what measures governments and individuals can take to respond to or prevent the damage of extreme heat. We used extreme heat and human health as keywords to collect the papers in the Embase database and review all the results. After sorting out all the results, the research focuses on the effect of extreme heat exposure on human physical and mental health. It can be found that extreme heat exposure causes heat-related illnesses (HRI) and aggravates chronic diseases, especially cardiovascular and respiratory diseases. And extreme heat can also lead to Preterm birth (PTB) which threatens the lives of pregnant women and infants. Mental health and related deaths are also affected by extreme heat exposure.
Older residents experience of loneliness in nursing homes: A qualitative study
Authors: Zhuansun Mengyao , Liu Lamei , Xu Tongyao , Qian Yumeng
Published: January 2024

Aims: This qualitative study investigates the multifaceted experiences of loneliness among elderly residents in long-term care facilities, delving into the intricacies of this pervasive issue. Loneliness is a detrimental issue among this vulnerable group, and understanding its impact on the well-being of older individuals is crucial in that it shows requirements of both humanitarian spirit and traditional moral code. Methods: In this research, a qualitative approach is employed among a diverse group of residents in a certain care home, including in-depth interviews, observational data, and content analysis of personal narratives. Results: Thematic analysis revealed accordingly several common themes related to loneliness, including the common feelings of loneliness, its contributing factors, and individual coping strategies. Conclusion: The findings underscore the complexity of the loneliness experience among the elderly living in care facilities and highlight the need for targeted interventions and policies in long-term care settings to address this significant issue. The insights gained from this research provide valuable information for future policymakers, healthcare providers, and care facility administrators in improving the well-being of elderly residents.
Research on causes, treatment, prevention of dental caries
Authors: He Xinyi
Published: January 2024

Dental caries is a disease which is affected by many factors, mainly bacteria, and eventually leads to the dissolution and damage of the hard tissue of the teeth. Dental caries has become one of the most common diseases affecting children worldwide, and it is on the rise, seriously endangering childrens oral, general and mental health. Traditional clinical treatment methods mainly use filler therapy and root canal therapy, but these are invasive and dependent on patients compliance. There are many therapies that are less invasive and more suitable for children being researched and applied clinically. It is worth noting that for caries, early prevention is more important and effective than late treatment. In recent years, the researches on the pathogenesis and influencing factors of dental caries have also made some progress. This review focuses on the causes, treatment and prevention of dental caries in children, in order to promote the updating of research trends on dental caries in children and to help develop an individualized oral health plan for children.
A review of research advances in the clinical management of adolescent depression
Authors: Liu Siyuan
Published: January 2024

With the change of time and the development of society, in recent years, the problem of depression among adolescents has attracted much attention in China and even in the world. Depression is a relatively common psychiatric disorder at this stage. Focusing on the clinical treatment methods of adolescent depression, this review summarizes and discusses the progress of psychotherapy, the progress of medication, and other physical therapy methods applied in todays clinic for treating adolescent patients with depression and finds that the psychotherapeutic method that is applied more in todays clinic is cognitive-behavioral therapy (CBT); medications such as fluoxetine are mostly used, but it is difficult to guarantee the safety of medication use, and the combination of Chinese and Western medications is often used in China. In China, a combination of Chinese and Western medicines is often used; at the same time, repetitive transcranial magnetic therapy is often used, and electroconvulsive therapy is occasionally used. At the same time, the combination of multiple therapies has a better effect.
Stem cell: Therapeutic approach and potential future
Authors: Lu Yuming
Published: January 2024

The numerous medical breakthroughs stem cell therapy can provide have led to stem cell research experiencing a surge in popularity. Thus, as modern technology develops, stem cell research may become a turning point for the medical field. Stem cell therapy provides several advantages over traditional treatments like surgical procedures, including lower risks, the absence of surgical wounds, and a non-invasive approach. Besides, undifferentiated organism treatment holds more potential to treat a more extensive assortment of illnesses compared with conventional medicines. This writing survey talks about late discoveries on numerous kinds of immature microorganisms, examining their sources, current clinical relevance, and expected potential outcomes. In particular, this audit looks at the accompanying areas of undeveloped cell research: undifferentiated cell treatment in regenerative medication; instigated pluripotent undifferentiated cells (iPSCs) and sickness demonstration; undeveloped cells and neurodegenerative infection; undeveloped cells and immunotherapy; undeveloped cells in regenerative medication; and, whats more, immature microorganisms and maturing. Through our examination, the paper has found that immature microorganisms have extraordinary potential for relieving infections that are impervious to conventional medicines. In any case, moral contemplations remain a worry, and there are as yet many difficulties to beat in the field. This audit means to sum up and look at the momentum of immature microorganism research while likewise featuring the far-reaching capability of undifferentiated cell movement in medication.
Obesity rates and its various impact to adults over the age of 18 in the United States
Authors: Han Yanbo
Published: January 2024

Obesity has become a global public health problem, which will negatively affect individual health along with the social economy, but there are fewer effective ways to control obesity and useful methods to prevent obesity from occurring. A data set about obesity rate was used as the basic data set, and the average obesity rate and BMI for each group were calculated using formulas of descriptive statistics. Then the results were shown through figures using the method of correlation analysis. Also, in addition, for a more comprehensive understanding of the differences between different regions, the study of Ward et al was also referred. Through analysis, obesity rates of adults in different age group in the U.S has a tendency of rising in recent years. There are also differences in obesity rates by various circumstances. In addition, there is a correlation between genetic factors, family environment, social impact, and obesity rates. And a high obesity rate will have bad effects on both adults in the society and the society itself. Obesity causes various impacts on adults over the age of 18 in America. And more usable and effective ways of dealing with obesity should be created.
Machine learning drug discovery based on graph neural network and large language model
Authors: Huang Tianqi
Published: January 2024

The COVID-19 pandemic has presented an urgent need to understand the long-term health implications faced by survivors. Post-COVID-19 complications, such as acute kidney injury, arrhythmia, and stroke, pose significant challenges to public health. Despite extensive research on COVID-19 complications, a comprehensive understanding of the risk factors remains elusive due to the potential confounding variables present in the data. Traditional statistical models, while insightful, may not fully capture the causal relationships between these risk factors and post-COVID-19 complications. Motivated by this gap in the literature, we propose a novel approach using causal inference models to predict the likelihood of post-COVID-19 complications based on patient demographics and pre-existing conditions. Our model, trained on a dataset of COVID-19 inpatients in Wuhan Province, China, estimates the causal effect of these factors on the likelihood of patients experiencing post-COVID-19 complications. This approach allows us to isolate the causal impact of each factor while accounting for potential confounders, providing a more accurate understanding of the underlying mechanisms driving these relationships. Unlike traditional models that predict the probability of certain outcomes, our model provides insights into the causal relationships between risk factors and complications, offering a more reliable and comprehensive understanding of the underlying mechanisms. This approach can help identify at-risk patients, inform targeted interventions, and contribute to the development of effective prevention and treatment strategies. Our work aims to contribute to the current understanding of the virus and inform public health policies and interventions.
Challenges Experienced by EFL Learners in the Context of the ESP Course at Qassim University, Saudi Arabia
Authors: Mohammed Abdulghani Eissa Tour , AbdAlgane Mohammed , Balla Asjad Ahmed Saeed , Ahmed Awwad Othman Abdelaziz
Published: January 2024

This study summarizes difficulties associated with studying a course entitled "English Language 01, with a university code (ENG 101) as a general university requirement course for non-specialist students taught to various departments at Qassim University. ENG 101, is a university preparatory course with an overall objective that goes beyond improving student English language skills, which remained a challenge for some students. Despite the clarity of its objectives, achieving these goals is difficult for some students, especially those who joined colleges with poor language skills. Thus, their problems go back to previous stages where traditional teaching methods were prevalent. Concerning data collection required for investigating problems associated with the present study, the researchers used a qualitative data collection technique that involves gathering and processing numerical data to conduct statistical analysis. Data analysis showed several significant findings, writing and listening respectively emerge as the most formidable talent, as evidenced by a great number of "Not Good At" responses, with the majority of participants experiencing difficulty with these two essential skills.
The Stress Influence on Population Health
Authors: Redzic Edina , Begic Dzenana , Zunic Lejla
Published: January 2024

Background: The term stress refers to the internal state of the organism (sometimes labeled as "load"), an external event ("stressor"), an experience created by the transaction of a person and the environment. Stress is an extremely used term in all areas of human activity. It is a natural phenomenon and a companion of mankind since its very existence. Although a large number of professional and scientific articles related to the concept of stress and reaction to stress have been published during the last 60 years, various authors state that not all concepts are clearly and unambiguously defined in this field. Objective: The aim of this paper is to present different theories of stress and to familiarize the reader about the consequences of everyday stress on human health. Methods: The subject of research is stress and its impact on health in today's modern world. The type of research on this topic is based on a retrospective and descriptive method based on the use of published articles in the PubMed and Scopus index databases. Results and Discussion: Therefore, different theories of stress define differently the concept of stress, reactions to stress, coping with stress and the consequences of a stressful event. Studies on stress was started by Hans Selye in the thirties of the 20th century. Understanding stress as the organism's reaction to various physical and physiological stressors, Selye also became the originator of the first, so-called of the reductionist model in the study of stress. Another theoretical approach in the concepts of stress boils down to the explanation that stress is determined by the nature of the stressor. This paradigm has been offered since the late sixties of the 20th century and is called the interactionist model of stress. At the same time as the interactionist model, a third, transactional model in the study of stress appeared, created by Richard Lazarus. According to this model, the consequences of a stressful transaction are the result of the interplay of personal and external factors that continuously affect each other. Conclusion: The stress is a state in which the psychophysical balance of the organism is disturbed and which, in order to adapt, requires additional efforts. Circumstances that cause stress are also called stressors. Among the psychological changes characteristic of stress, the most pronounced are changes in the sphere of emotional processes. Emotional reactions characteristic of stress are most often anxiety, anger and sadness, and shame, guilt, oversaturation can also occur. After a traumatic or other intense stress (related to losses or diagnosed with an incurable disease), emotional flattening can occur. Changes in psychological functioning during stress can be so intense that they take on the dimensions of a psychological crisis.