bluuebunny/crossref_metadata_2025 huggingface dataset:
Unraveling Cadmium Toxicity in Trifolium repens L. Seedling: Insight into Regulatory Mechanisms Using Comparative Transcriptomics Combined with Physiological Analyses
Authors: Wu Feifei , Fan Jinwan , Ye Xiuwen , Yang Lili , Hu Ruchang , Ma Jieyu , Ma Sainan , Li Dandan , Zhou Jiqiong , Nie Gang , Zhang Xinquan
Published: April 2022

Trifolium repens (T. repens) can accumulate significant amounts of heavy metal ions, and has strong adaptability to wide environmental conditions, and relatively large biomass, which is considered a potential plant for phytoremediation. However, the molecular mechanisms of T. repens involved in Cd tolerance have not yet been studied in detail. This study was conducted to examine the integrative responses of T. repens exposed to a high-level CdCl2 by investigating the physiological and transcriptomic analyses. The results suggested that T. repens seedlings had a high degree of tolerance to Cd treatment. The roots accumulated higher Cd concentration than leaves and were mainly distributed in the cell wall. The content of MDA, soluble protein, the relative electrolyte leakage, and three antioxidant enzymes (POD, SOD, and APX) was increased with the Cd treatment time increasing, but the CAT enzymes contents were decreased in roots. Furthermore, the transcriptome analysis demonstrated that the differentially expressed genes (DEGs) mainly enriched in the glutathione (GSH) metabolism pathway and the phenylpropanoid biosynthesis in the roots. Overexpressed genes in the lignin biosynthesis in the roots might improve Cd accumulation in cell walls. Moreover, the DEGs were also enriched in photosynthesis in the leaves, transferase activity, oxidoreductase activity, and ABA signal transduction, which might also play roles in reducing Cd toxicity in the plants. All the above, clearly suggest that T. repens employ several different mechanisms to protect itself against Cd stress, while the cell wall biosynthesis and GSH metabolism could be considered the most important specific mechanisms for Cd retention in the roots of T. repens.
The Phytotoxin Myrigalone A Triggers a Phased Detoxification Programme and Inhibits Lepidium sativum Seed Germination via Multiple Mechanisms including Interference with Auxin Homeostasis
Authors: Nakabayashi Kazumi , Walker Matthew , Irwin Dianne , Cohn Jonathan , Guida-English Stephanie M. , Garcia Lucio , Pavlović Iva , Novák Ondřej , Tarkowská Danuše , Strnad Miroslav , Pérez Marta , Seville Anne , Stock David , Leubner-Metzger Gerhard
Published: April 2022

Molecular responses of plants to natural phytotoxins comprise more general and compound-specific mechanisms. How phytotoxic chalcones and other flavonoids inhibit seedling growth was widely studied, but how they interfere with seed germination is largely unknown. The dihydrochalcone and putative allelochemical myrigalone A (MyA) inhibits seed germination and seedling growth. Transcriptome (RNAseq) and hormone analyses of Lepidium sativum seed responses to MyA were compared to other bioactive and inactive compounds. MyA treatment of imbibed seeds triggered the phased induction of a detoxification programme, altered gibberellin, cis-(+)-12-oxophytodienoic acid and jasmonate metabolism, and affected the expression of hormone transporter genes. The MyA-mediated inhibition involved interference with the antioxidant system, oxidative signalling, aquaporins and water uptake, but not uncoupling of oxidative phosphorylation or p-hydroxyphenylpyruvate dioxygenase expression/activity. MyA specifically affected the expression of auxin-related signalling genes, and various transporter genes, including for auxin transport (PIN7, ABCG37, ABCG4, WAT1). Responses to auxin-specific inhibitors further supported the conclusion that MyA interferes with auxin homeostasis during seed germination. Comparative analysis of MyA and other phytotoxins revealed differences in the specific regulatory mechanisms and auxin transporter genes targeted to interfere with auxin homestasis. We conclude that MyA exerts its phytotoxic activity by multiple auxin-dependent and independent molecular mechanisms.
Enhancer RNA AL928768.3 from the IGH Locus Regulates MYC Expression and Controls the Proliferation and Chemoresistance of Burkitt Lymphoma Cells with IGH/MYC Translocation
Authors: Stasevich Ekaterina Mikhailovna , Uvarova Aksinya Nicolaevna , Murashko Matvey Mikhailovich , Khabusheva Elmira Ramilevna , Sheetikov Saveliy Andreevich , Prassolov Vladimir Sergeyevich , Kuprash Dmitriy Vladimirovich , Demin Denis Eriksonovich , Schwartz Anton Markovich
Published: April 2022

Chromosomal rearrangements leading to the relocation of proto-oncogenes into transcription-active regions are found in various types of tumors. In particular, the transfer of proto-oncogenes to the locus of heavy chains of immunoglobulins (IGH) is frequently observed in B-lymphomas. The increased expression of the MYC proto-oncogene due to IGH/MYC translocation is detected in approximately 85% of Burkitt lymphoma cases. The regulatory mechanisms affecting the oncogenes upon translocation include non-coding enhancer RNAs (eRNAs). We conducted a search for the eRNAs that may affect MYC transcription in the case of IGH/MYC translocation in Burkitt lymphoma, looking for potentially oncogenic eRNAs located at the IGH locus and predominantly expressed in B cells. Overexpression and knockdown of our primary candidate eRNA AL928768.3 led to the corresponding changes in the expression of MYC proto-oncogene in Burkitt lymphoma cells. Furthermore, we demonstrated that AL928768.3 knockdown decreased lymphoma cell proliferation and resistance to chemotherapy. Significant effects were observed only in cell lines bearing IGH/MYC abnormality but not in B-cell lines without this translocation nor primary B-cells. Our results indicate that AL928768.3 plays an important role in the development of Burkitt’s lymphoma and suggest it and similar, yet undiscovered eRNAs as potential tissue-specific targets for cancer treatment.
The Use of Molecular Dynamics Simulation Method to Quantitatively Evaluate the Affinity between HBV Antigen T Cell Epitope Peptides and HLA-A Molecules
Authors: Mei Xueyin , Li Xingyu , Zhao Chen , Liu Anna , Ding Yan , Shen Chuanlai , Li Jian
Published: April 2022

Chronic hepatitis B virus (HBV), a potentially life-threatening liver disease, makes people vulnerable to serious diseases such as cancer. T lymphocytes play a crucial role in clearing HBV virus, while the pathway depends on the strong binding of T cell epitope peptide and HLA. However, the experimental identification of HLA-restricted HBV antigenic peptides is extremely time-consuming. In this study, we provide a novel prediction strategy based on structure to assess the affinity between the HBV antigenic peptide and HLA molecule. We used residue scanning, peptide docking and molecular dynamics methods to obtain the molecular docking model of HBV peptide and HLA, and then adopted the MM-GBSA method to calculate the binding affinity of the HBV peptide–HLA complex. Overall, we collected 59 structures of HLA-A from Protein Data Bank, and finally obtained 352 numerical affinity results to figure out the optimal bind choice between the HLA-A molecules and 45 HBV T cell epitope peptides. The results were highly consistent with the qualitative affinity level determined by the competitive peptide binding assay, which confirmed that our affinity prediction process based on an HLA structure is accurate and also proved that the homologous modeling strategy for HLA-A molecules in this study was reliable. Hence, our work highlights an effective way by which to predict and screen for HLA-peptide binding that would improve the treatment of HBV infection.
The role of digitalization in the development of regions and the use of their potential in terms of sustainable development
Authors: Kondratenko Nataliia , Papp Vasyl , Romaniuk Mykhailo , Ivanova Olha , Petrashko Liudmyla
Published: April 2022

The study substantiates the determining role of digitalization and its tools in the development of regions and the use of their potential in terms of sustainable development. The methodological basis of the study was a systemic and process approach, as well as a dialectical method of scientific knowledge. Clarification of the main features of the potential of the regions and its properties made it possible to highlight the importance of digitalization for the economic development of regions and the achievement of sustainable development goals. The directions of increasing the efficiency of the information and communication environment of the regions are substantiated. The role of digitalization development in increasing the involvement of potential opportunities of regions in their development to ensure the achievement of sustainable development goals and ways to stimulate the activation of the potential of regions through digitalization. It is proved that digitalization contributes to the activation and transformation of the potential of regions, its transformation into capital and the formation of new potential that raises social, economic, environmental living standards of all segments of the population, increasing the competitiveness of regions.
Self-education culture of future music teachers: diagnostic and formative methods
Authors: Savchenko-Shlapak Yuliia , Savchenko Rehina , Lendiel-Syarkevich Antonina , Strohal Tetyana , Pavliuk Yuliia
Published: April 2022

The article highlights the results of an experimental study on the formation of a culture of self-education of future music teachers in vocal and choral training. The purpose of the study is to evaluate the developed methodology for the formation of a culture of self-education of future teachers of musical art in the process of studying vocal and choral disciplines. The study was carried out by the method of paired comparisons, based on the results of which a scale of comparative assessments was built in the control and experimental groups. The effectiveness of the proposed technique is confirmed by the results of statistical processing of experimental data. Criteria for monitoring the formation of a culture of self-education of future teachers of musical art in vocal and choral training are indicated. The effectiveness of the applied technique was assessed by a series of tests comparing the results at the ascertaining and formative stages of the study. The authors argue that the data of the formative experiment showed significant positive changes in the levels of formation of the culture of self-education of future teachers of musical art according to all the established criteria.
Тhe nature and characteristics of the evolution of the phenomenon of geopolitics
Authors: Omelchenko Oksana A. , Kononenko Oleksandr V. , Livinsky Victor M. , Evminov Sergey V. , Olendiy Iryna A. , Ovramets Mikhail A.
Published: April 2022

The article has revealed the nature of the phenomenon of geopolitics as being the basis of the international relations and serving both as a scientific methodology to explain the behavior and relationships of a state with other countries in accordance with the geographical location and the interests. The concept of modern geopolitics is multifaceted, and scientists disagree regarding the definition of geopolitics as an independent science. Geopolitics is a methodology of international relations and foreign policy. Ultimately, the key to modern understanding of geopolitics is the policy and the image of a state within its geographical location, which can impact other subjects / objects of international life to ensure their national interests and national security. A number of conceptual approaches have been formed in the scientific discourse aiming to ensure the geopolitical advantage of a state. New processes and conflicts have been associated with the expansion of the Internet space and information technology. Recently, geopolitical theories have taken into account the latest tools and capabilities to influence used by leading states, including use of information, "hybrid" and "semantic" warfares. One of most urgent problems of the modern world is information warfare targeting creation of favorable conditions to gain geopolitical and geo-economic priority.
Estabilidad emocional como factor del bienestar psicológico de futuros especialistas
Authors: Halian Ihor , Kurova Anastasiia , Skliaruk Anastasia , Halian Olena , Khokhlov Artem
Published: April 2022

El estudio fue realizado para fundamentar teóricamente y empíricamente los factores de la estabilidad emocional como cualidad sistémica del individuo, que ayuda a futuros profesionales en la autodeterminación profesional a adaptarse efectivamente al espacio educativo y contribuye al desarrollo de la sensación de bienestar psicológico. En el estudio participaron los estudiantes (n = 277) de diferentes años de estudios (nI=112; nIII=97; nV=68), que recibían la educación superior en especialidades socionómicas. Se utilizó las técnicas de psicodiagnóstico, que son válidas y fiables. Se estudió la conexión entre la estabilidad emocional y la autorrealización durante los siguientes años de estudios: 1 año (rs=.216; p<.05); III (rs=.346; p<.001); V (rs=.411; p<.001). Se registró el crecimiento de estabilidad emocional (C) (t = -3.301; p <.0021), ansiedad (O) (t = -2.682; p <.0015) y expresividad (F) (t = -2.916; p <.0034). Se estableció la correlación entre la adaptación sociopsicológica y la estabilidad emocional de los encuestados: I (rs = .432; p <.001); III (rs = .331; p < .001); V (rs = .422; p < .001). Está fundamentado y aprobado empíricamente que el bienestar psicológico se basa en la idea de necesidad constante y la capacidad del hombre al autodesarrollo y la autorrealización.
Flipped Classrooms using Blackboard to Enhance the Instructional Design Skills of Postgraduate Students
Authors: Alenezi Farhan Yetaim
Published: April 2022

This study aims to determine the impact of using the flipped classroom approach through Blackboard, to enhance students’ instructional design skills, and identify any challenges that may limit this us.

The study was carried out at the Northern Border University in Saudi Arabia in academic year 2020/2021, with ten students on the Instructional Design Course. The study uses a mixed methods approach, employing both a quantitative research method (test), and a qualitative method (semi-structured interviews).

The study produced several results, the most important of which being the effectiveness of using flipped classrooms in the development of instructional design skills. The study reveals a set of challenges that may limit the use of the flipped classrooms strategy through Blackboard, split into three sections. The first section includes the challenges relating to faculty members. The second section comprises the challenges relating to students. The third section incorporates external challenges.
Media coverage of the Olympic Games
Authors: Sydorenko Natalia , Volobuieva Anastasiia
Published: April 2022

The Olympic Games have always occupied a special place in the information environment. Coverage of the preparation of these important competitions in modern media discourse deserves more detailed consideration. This is due to the development of new media, in particular, social networks and a kind of competition with traditional media. Accordingly, the aim of the work is to analyze the peculiarities of the coverage of the Olympic Games in the media. As a result of the study, it was concluded that since the London Olympics in 2012, traditional media have experienced strong competition from social networks (eg, Facebook, Twitter). As a result, new media promote active communication, which allows individual consumers to create content in a very specific way. At the same time, there are alarming trends in the use of the media in information or political confrontation, which is a threat to freedom of expression. In order to analyze the coverage of the Olympic Games in the media, general theoretical research methods are used, including analysis and synthesis. The conclusions conclude that modern media contribute to the promotion of the Olympic movement in the world, and the use of the latest media opportunities significantly democratize and diversify this process.
Efectividad del aplicativo de resultados críticos para el apoyo al diagnóstico y terapéutico de pacientes crónicos atendidos en una Clínica privada entre el 2017 y 2018
Authors: Huapaya-Huertas Oscar , Llanos-Zavalaga Fernando , Valcarcel-Valdivia Steven , Arenas-Siles Daniella , Apolaya-Segura Moisés
Published: April 2022

Introducción: La oportuna prestación de servicios de salud es clave para reducir la morbimortalidad de pacientes crónicos, especialmente cuando se requiere una atención frente a un resultado crítico de exámenes auxiliares. En ese contexto, se evalúa un aplicativo web de resultados críticos en una Clínica privada acreditada por Joint Commission International (JCI). Objetivos: el presente estudio busca evaluar la efectividad de un aplicativo web en el reporte de resultados críticos de pacientes crónicos. Material y métodos: Se realizó un estudio de cohorte retrospectiva. Se compararon dos etapas: la etapa de línea de base (implementación del software) versus la etapa final (evaluación). Resultados: Se registraron 122 resultados críticos de pacientes crónicos en la etapa de implementación y 113 en la etapa de evaluación. Se encontró una disminución en la media del tiempo de respuesta del profesional en la etapa de evaluación con relación a la etapa de implementación. La transcripción en los registros incrementó del 75,4% al 93,8% p<0,001, la continuidad de la atención por el mismo médico incrementó del 41,0% al 54,9% p<0,03. Asimismo, se redujo en 68% la probabilidad de fallecimiento. Conclusiones: El aplicativo web de resultados críticos mejoró el registro de la atención y redujo la mortalidad de pacientes crónicos que tuvieron un resultado crítico.
Efectos de una intervención con llamadas telefónicas educativas para mejorar la adherencia y el control metabólico en personas con diabetes mellitus tipo 2 mal controlada: Un ensayo clínico aleatorizado
Authors: De La Cruz-Saldaña Tania , Lazo-Porras María , Ticse-Aguirre Ray , Morán Dulce , Málaga Germán
Published: April 2022

Introducción: Las tecnologías de información y comunicación pueden ayudarnos a mejorar el control metabólico y la adherencia de las personas con diabetes mellitus tipo 2 (DM2). Objetivo: Evaluar los efectos de una intervención con llamadas telefónicas en pacientes ambulatorios con DM2 mal controlada de un hospital en Perú. Material y Métodos: Ensayo clínico aleatorizado. Incluimos adultos con DM2 con mal control glicémico (HbA1c > 7%), quienes fueron aleatorizados al grupo control (cuidado usual) o al grupo intervención (cuidado usual más una intervención con llamadas telefónicas cada dos semanas por tres meses). El desenlace principal fue la reducción ≥ 1% de hemoglobina glicosilada a los tres meses. Resultados: Se reclutó 94 participantes (47 en cada grupo). La edad promedio fue 59,8 años (DE: 10,2), 69,2 % fueron mujeres. A los tres meses, solo 14/47 participantes del grupo control y 13/47 participantes del grupo intervención tuvieron medición de HbA1c. Entre estos, el porcentaje de los que lograron una disminución ≥ 1% de HbA1c fue de 35,7% (5/14) en el grupo control y 53,8% (7/13) en el grupo intervención (RR: 0,72, IC 95%: 0,35-1,47). No se encontró diferencias en la adherencia al tratamiento entre ambos grupos. Conclusiones: No se encontró diferencias estadísticamente significativas para los desenlaces de interés. Posiblemente esto se deba al bajo porcentaje de participantes a los que se logró completar el seguimiento.
Hormona adrenocorticotropa en pacientes con síndrome de West y progresión al síndrome de Lennox-Gastaut
Authors: Campos-Olazabal Patricia , Hurtado-Roca Yamilee , Montúfar-Crespoc S. Marcela
Published: April 2022

Introducción: Se evaluará el uso de la hormona adrenocorticotropa como tratamiento del síndrome de West (síndrome de Lennox-Gastaut) y el tiempo requerido para la progresión hacia la evolución grave. Existen escasos datos sobre esta patología para nuestra población. Material y Métodos: Se trata de una cohorte donde se analizaron 139 historias clínicas de pacientes evaluados en dos unidades de pediatría de la ciudad de Lima entre los años 2000 y 2010. Se incluyeron todos los pacientes que cumplían con los criterios: 1) Espasmos masivos, 2) Retraso en el desarrollo psicomotor y 3) Electroencefalograma que mostró hipsarritmia. Se administró hormona adrenocorticotropa como tratamiento posterior al diagnóstico. El período de seguimiento duró 10 años. Resultados: El cociente de riesgo (CR) de la progresión al Síndrome de Lennox-Gastaut en pacientes que utilizaron la hormona adrenocorticotropa en comparación con aquellos sin hormona adrenocorticotropa fue de 0,45 (IC del 95%: 0,24-0,83, p=0,011). El CR de la progresión al Síndrome de Lennox-Gastaut ajustado para todas las variables estudiadas (edad de inicio, sexo, frecuencia de las crisis, etiología y tiempo desde el diagnóstico hasta el inicio del tratamiento) en pacientes que utilizaban la hormona adrenocorticotropa en comparación con aquellos sin hormona adrenocorticotropa fue de 0,56 (IC del 95%: 0,29 a 0,08; p=0,085). Conclusiones: El uso de la hormona corticotropina en pacientes con síndrome de West podría proteger contra la progresión al síndrome Lennox-Gastaut. Consideramos que esto apoya la evidencia encontrada en poblaciones similares a la nuestra, y creemos que este hallazgo podría ser confirmado con ensayos clínicos.
Diferencias laborales entre personas con discapacidad adquirida y sobrevenida en edad adulta. Análisis secundario de la Encuesta Nacional de Discapacidad – ENEDIS 2012
Authors: Rojas-Villegas Miguel , Osada-Liy Jorge
Published: April 2022

Objetivo: Evaluar diferencias laborales entre personas con discapacidad adquirida y discapacidad sobrevenida en edad adulta. Material y Métodos: Estudio transversal analítico secundario de la Encuesta Nacional de Discapacidad (ENEDIS) 2012. Se incluyeron personas entre 14 y 65 años de edad, agrupándolas según discapacidad (adquirida, sobrevenida temprana, sobrevenida adulta). Se consideraron como resultados finales de interés: tener trabajo, ser trabajador dependiente o independiente, contar con contrato y tener ingresos superiores a la remuneración mínima vital. Se realizo análisis bivariados y múltiples considerando el muestreo complejo de los datos. Resultados: Se estudiaron a 16060 personas, 27,92 % presentaron discapacidad adquirida, 10,45 % sobrevenida temprana y 61,63 % sobrevenida adulta. Se encontró que aquellas con discapacidad sobrevenida adulta tenían una mayor frecuencia de: tener trabajo (34,93 vs 23,20 %, p < 0,001), contar con contrato (50,40 vs 27,74 %, p < 0,001) y tener mayores ingresos (18,18 vs 13,29 %, p=0,048), respecto a las personas con discapacidad adquirida. Al realizar el análisis de regresión múltiple, las diferencias del ingreso económico y tipo de contrato disminuyen (p<0,05), pero la probabilidad de tener trabajo en la discapacidad sobrevenida adulta se invierte de 51% más a 8% menos (p=0,057). Conclusiones: Las personas con discapacidad sobrevenida en edad adulta presentan más empleo e ingresos económicos que aquellas con discapacidad adquirida. Aparentemente esto no depende del tiempo de discapacidad (que es menor en la discapacidad sobrevenida adulta) sino principalmente a factores como edad, sexo, grado de instrucción, región de residencia y tipo de limitación.
Impacto del triaje estructurado en el hacinamiento del servicio de emergencia de un hospital terciario
Authors: Taype-Huamaní Waldo Augusto , De-La-Cruz-Rojas Lucila Amelia , Amado-Tineo José Percy
Published: April 2022

Objetivo: Evaluar el impacto del triaje estructurado en indicadores de hacinamiento del servicio de urgencias (SU) de un hospital terciario. Material y Métodos: Estudio observacional retrospectivo de diseño pre y post. Realizado en un hospital de la seguridad social, comparando las atenciones de dos trimestres. Se evaluó la implementación de triaje estructurado de cinco prioridades tipo Manchester, comparando número de atenciones, atendidos, prioridad de atención, tópico de ingreso, pacientes no atendidos, fallecidos en las primeras 6 horas y tiempo de primera atención. Con datos del sistema institucional se realizó el análisis estadístico (intervalo de confianza de 95%) utilizando SPSS 24.0, con aprobación institucional. Resultados: 42000 atenciones por trimestre, donde el 12% fue admitida a salas de observación. Mediana de edad 57 años (rango 14 - 103), sexo femenino 57%. Promedio diario de pacientes amanecidos en SU 240 vs 230 (p<0,01). Prioridad al ingreso: I 3%, II 44%, III 37%, IV 16% y V 0%. En el segundo trimestre disminuyeron las atenciones en prioridad I y se incrementaron en prioridad II y III. El promedio diario de pacientes no evaluados fue 20,5 y 13,7 en cada trimestre. Falleció en las primeras 6 horas el 0,13 y 0,15% del total de admisiones, según periodo de estudio. El tiempo promedio en el SU después de la primera atención fue 5,2 horas, disminuyendo en el segundo trimestre en todas las áreas. Conclusión: El sistema de triaje estructurado tipo Manchester disminuye la proporción de pacientes no atendidos, número de atendidos con prioridad I y tiempo en urgencia después de la primera atención.
Diversidad genómica en SARS-CoV-2: Mutaciones y variantes
Authors: Aguilar-Gamboa Franklin Rómulo , Suclupe-Campos Danny Omar , Vega-Fernández Jorge Arturo , Silva-Diaz Heber
Published: April 2022

Introducción: La variabilidad genética del SARS-CoV-2 ha incrementado notablemente desde que se declaró la pandemia, lo que le ha permitido representar un continuo desafió para las políticas de salud destinadas a su control. Objetivo. Describir la nomenclatura genómica utilizada para la comunicación general y científica sobre el SARS-CoV-2, así como describir las mutaciones, evolución, origen y variantes del virus. Material y Metodos. Se realizó una revisión narrativa de literatura, para el cual se realizó una búsqueda y análisis de la información hasta el 15 de diciembre de 2021. Se revisaron 74 fuentes seleccionados desde las bases de datos MEDLINE/ PubMed, SciELO, LILACS y páginas web oficiales; sin restricciones de idioma. Resultados. Las mutaciones son cambios en la secuencia de nucleótidos del genoma viral, que, al producir afectación de la dinámica epidemiológica en una población, dan lugar a variantes, y estos a su vez a clados diferenciados. Entre las variantes de interés destacan Lambda y Mu, identificadas por primera vez en Perú y Colombia, respectivamente. Mientras que, las variantes de preocupación, en orden cronológico, son la Alfa (británica), Beta (sudafricana), Gamma (brasilera), Delta (india) y recientemente Ómicron. Conclusiones. Se concluye que la diversidad genómica del SARS-CoV-2 se debe a su elevada tasa de mutaciones que pueden constituirse en variantes y clados. La mejor comprensión de esta diversidad permite tomar medidas de control más eficaces, guiando el desarrollo y uso de vacunas, terapias, diagnóstico y políticas en salud.
Tratamiento integral de la osificación heterotópica en politraumatismo con traumatismo encéfalo craneano reporte de un caso
Authors: Muñoz-Maldonado María Carolina , Vallés-Casanova Margarita , Dachs-Cardona Frederic , Del Arco Alejandro , Ledesma Lidia
Published: April 2022

Introducción: La osificación heterotópica (OH) es una complicación descrita en los pacientes con daño neurológico. Reporte de caso: Paciente que sufrió un politraumatismo y traumatismo encéfalo craneano (TEC), con fracturas y déficit neurológico secundario al TEC, quien presentó varias osificaciones heterotópicas durante su evolución, que comprometieron el logro de los objetivos funcionales. Presentó como principal manifestación tumefacción y limitación del rango articular (RA) para la extensión de cadera y rodilla izquierda, lo que mantenía el miembro inferior izquierdo (MI) flexionado, impidiendo la bipedestación y marcha. Fue diagnosticado como osteoma secundario a trauma neurológico y recibió un manejo médico estructurado, que incluyó la intervención quirúrgica: “resección del osteoma y tenotomía en isquiotiobiales”, obteniendo mejora del rango articular, logrando la bipedestación y marcha con apoyo biomecánico. Discusión: La fisiopatología se cree que está relacionada a la liberación sistémica de sustancias estimulantes de células madre pluripotenciales, que se diferencian como osteoblastos. Conclusión: Un manejo integral multidisciplinario provee mejores resultados funcionales, lo que contribuye a la meta de la independencia.
Pólipos linfangiomatosos de las amígdalas palatinas en la infancia: Reporte de un caso y revisión
Authors: Lugo-Machado Juan Antonio , Medina-Valentón Elizabeth , Guerrero-Paz José Alberto , Jacobo-Pinelli Regina , Jiménez-Rodríguez Martha , Quintero-Bauman Alejandro , Gutiérrez-Pérez Martha Lucía
Published: April 2022

Introducción: Los pólipos linfangiomatosos de las amígdalas palatinas son lesiones benignas raras. Esta entidad se origina en el estroma linfoide mezclándose con el parénquima, siendo diferente a la hiperplasia papilar y representa aproximadamente el 1,9% de las neoplasias de amígdalas. Objetivo: Presentar un caso clínico y una búsqueda sistemática de los casos pediátricos publicados en la literatura. Reporte de caso: se ha realizado una revisión sistemática siguiendo las pautas PRISMA de los reportes en PubMed, Elsevier, Google Académico de 2010 a 2021. Se localizaron 18 artículos en los que se encontró 8 mujeres y 10 hombres, la edad promedio fue de 14 años, en 15 las lesiones eran unilaterales. Todos los casos reportaron en los hallazgos histopatológicos la presencia de vasos linfáticos. Conclusión: Existe variabilidad entre la edad con distribución similar entre sexos; al ser una entidad infrecuente hay heterogeneidad en su denominación.
Abordaje inicial del paciente intoxicado por monóxido de carbono: Una aproximación terapéutica
Authors: Serna-Trejos Juan Santiago , Martinez-Parada Isabella , Agudelo-Quintero Esteban , Prado-Molina Diego Gerardo
Published: April 2022

Carta al editor (sin resumen)
COVID-19 Olgularında Yoğun Bakım Gereksiniminin Değerlendirilmesinde Tiyol ve İskemi Modifiye Albuminin Rolü
Authors: EREN Funda , NEŞELİOĞLU Salim , FIRAT OĞUZ Esra , FIRAT Rıdvan , İNAN Osman , GEMCİOĞLU Emin , ŞAHİNER Enes , ATEŞ İhsan , EREL Özcan
Published: April 2022

Amaç: Korona virüs hastalığı (COVID 19) 4,5 milyondan fazla insanın ölümüne sebep olmuş küresel bir halk sağlığı sorunudur. Bu çalışmada, yataklı servis ve yoğun bakım ünitesinde tedavi alan COVID-19 hastalarının tiyol ve iskemi modifiye albumin (İMA) düzeylerinin, hastaların mevcut klinik durumu ve hastalığın seyri ile olan ilişkisinin değerlendirilmesi amaçlanmıştır.
Materyal ve metod: Bu çalışmaya, PCR testi ile pozitif olduğu doğrulanmış, COVID-19 enfeksiyonu tanısı alan 300 hasta dahil edilmiştir. Hastalar tedavi edildiği birim esas alınarak iki gruba ayrılmıştır. Bu hastaların 160’ı serviste (grup 1), 140’ı yoğun bakım birimlerinde (grup 2) tedavi edilmiştir. Hastaların numunelerinde tiyol, İMA, CRP, ferritin ve lenfosit düzeylerinin ölçümü gerçekleştirilmiştir.
Bulgular: Gruplar karşılaştırıldığında grup 2’nin tiyol düzeyleri önemli derecede düşük bulunmuştur (p<0,001). Ayrıca grup 2’nin İMA düzeylerinin, grup 1’e göre anlamlı düzeyde yüksek olduğu gözlenmiştir (p<0,001). Diğer laboratuvar testleri değerlendirildiğinde, grup 2’nin CRP ve ferritin düzeyi yüksek (p<0,001), lenfosit sayısı ise düşük (p<0,001) olarak belirlenmiştir. Tiyol düzeyleri ile CRP, ferritin, lenfosit ve İMA düzeyleri arasında anlamlı korelasyon saptanmıştır (sırasıyla r=-0,58; p<0,001, r=-0,41; p<0,001, r=-0,32; p<0,001, r=-0,39; p<0,001 ). Ayrıca İMA düzeyleri ile CRP, ferritin, lenfosit ve tiyol düzeyleri arasında anlamlı korelasyon gözlenmiştir (sırasıyla r=0,19; p=0,02, r=0,18; p=0,043, r=-0,15; p=0,047, r=-0,39; p<0,001).
Sonuç: COVID-19 hastalarında güçlü bir antioksidan olan tiyol düzeyinin azalması, oksidatif strese sebep olan mevcut inflamatuvar süreçten kaynaklanmakla beraber tromboza sekonder gelişen iskemik şartlara bağlı oksidatif stresin etkisi ile de ortaya çıkmış olabileceğini düşündürmektedir. Dolayısıyla inflamatuvar sürecin ve trombotik olayların daha şiddetli olarak gözlendiği yoğun bakım hastalarında İMA düzeylerinin artması, tiyol düzeylerinin azalmasını destekleyecek niteliktedir. Sonuç olarak yataklı serviste ve yoğun bakım ünitesinde tedavisi gerçekleştirilen COVID-19 hastalarının tiyol ve İMA düzeylerinin belirlenmesi, hastaların mevcut klinik durumu ve hastalığın seyri hakkında yardımcı olabilecek bir potansiyele sahip olduğunu düşündürmektedir.
Funcionalización de matrices a base de polímeros biodegradables mediante incorporación de nanopartículas
Authors:   , Marín Silva Diego Alejandro
Published: April 2022

La Tesis subraya la importancia de encontrar materiales ecológicos para aplicaciones innovadoras. En este marco, se obtuvieron nanopartículas de plata (NpAg) y cobre (NpCu) a partir de metodologías amigables con el medioambiente y se sintetizaron y modificaron nanopartículas de dióxido de titano (NpTiO2). Se propuso la incorporación de estas nanopartículas a matrices de quitosano (Q) y alcohol polivinílico (PVA) para obtener películas biodegradables potencialmente atractivas para el sector de biomedicina y de envases como así también para el desarrollo de materiales autolimpiantes. Por otra parte, se optimizó la fabricación de nanoestructuras electrohiladas a base de PVA y PVP funcionalizadas con NpCu. Estos materiales fueron propuestos como filtros para retención de material particulado, realizándose ensayos de aplicación en sistemas de monitoreo reales. Para completar este estudio se llevaron a cabo ensayos de toxicidad, citoxicidad y biodegradabilidad de los materiales desarrollados que pusieron de manifiesto la potencialidad de los mismos para las aplicaciones propuestas.
COVID-19 Positive Neonates from Pregnant Women with COVID-19 in Kasih Ibu Hospital Surakarta
Authors: Amorita Nabila Arnest , Santoso Mas Nugroho Ardi
Published: April 2022

Kasih Ibu Hospital from October 2019 to January 2021 has become the referral maternal COVID-19 hospital in Surakarta, Central Java. Until now, research on pregnant women with COVID-19 in Indonesia is still very limited, it is still unknown whether there are possibility of vertical transmission from mother to baby, while pregnant women are among the vulnerable population. The purpose of this study is to provide an overview of the findings of positive infant outcomes for COVID-19 in pregnant women with confirmed COVID-19 at Kasih Ibu Hospital, Surakarta. Data collection was carried out by tracing medical records which were then presented in the form of distributions based on gestational age, infant birth weight, infant APGAR score, and infant COVID-19 status. Out of 62 pregnant women confirmed positive for COVID-19, 20 babies (32.3%) had PCR swab tests positive for COVID-19. All babies were born in good shape (APGAR score 8-10) and 4 babies were found with low birth weight, one of whom also had hypospadias. There were no reports of neonatal asphyxia and infant mortality.
Efek Hepatoprotektor Ekstrak Etanol Batang Bajakah Tampala (Spatholobus Littoralis Hassk) pada Tikus yang Diinduksi Isoniazid
Authors: Adhityasmara Dhimas , Ramonah Dewi
Published: April 2022

Tujuan penelitian ini yaitu untuk mengetahui pengaruh pemberian dan dosis efektif ekstrak etanol batang bajakah terhadap penurunan SGOT & SGPT tikus putih jantan galur Wistar yang diinduksi isoniazid. Penelitian ini merupakan jenis penelitian eksperimental, dengan obyek penelitian penurunan kadar SGPT & SGOT setelah diberikan senyawa uji selama 14 hari. Dosis sediaan ekstrak etanol batang bajakah yang digunakan adalah dosis 200, 300 dan 400 mg/kgBB. Kontrol positif  digunakan   silymarin   dosis   5 mg/200gBB.  Sebagai  penginduksi  digunakan isoniazid  dosis 350 mg/KgBB  yang diberikan 14 hari sebelum perlakuan senyawa uji. Kelompok  normal  tanpa  diberi  perlakuan  untuk  mengetahui  pengaruh  lingkungan  terhadap hewan uji. Hasil penelitian menunjukan ekstrak etanol batang bajakah tampala memiliki efek hepatoprotektor pada tikus jantan yang dinduksi isoniazid 350mg/kgBB selama 14 hari. Dosis efektif ekstrak etanol batang bajakah sebagai hepatoprotektor adalah 200 mg/kgBB.Kata kunci: Bajakah tampala; hepatoprotektor; isoniazidHepatoprotector Effects of Bajakah Tampala Stem Ethanol Extract (Spatholobus Littoralis Hassk) on Isoniazid Induced RatsABSTRACTThe purpose of this study was to determine the effect of administration and effective dose of ethanol extract of bajakah stems on the reduction of SGOT & SGPT of isoniazid-induced male white rats of Wistar strain. This research is an experimental type of research, with the object of research decreasing levels of SGPT & SGOT after being given the test compound for 14 days. The dosages of the ethanol extract of the bajakah stem used were doses of 200, 300 and 400 mg/kgBW. The positive control used silymarin at a dose of 5 mg/200gBW. As an inducer, isoniazid at a dose of 350 mg/KgBW was used 14 days before the treatment of the test compound. The normal group without treatment was to determine the effect of the environment on the test animals. The results showed that the ethanol extract of Bajakah tampala rods had a hepatoprotective effect on male rats induced by isoniazid 350mg/kgBW for 14 days. The effective dose of ethanol extract of bajakah stem as a hepatoprotector was 200 mg/kgBW.Keywords: Bajakah tampala; hepatoprotector; isoniazid
Analisis Faktor-Faktor Usaha Berkelanjutan bagi UMKM di Kabupaten Bengkulu Tengah
Authors:   Prodi Akuntansi, Universitas Prof. Dr. Hazairin, SH, Bengkulu, arnova Iwin
Published: April 2022

Abstract Purpose: of this study was to analyze the business capital, technology, quality, and education of Micro, Small and Medium Enterprises of Karya Rattan Bengkulu. Methods: The sampling technique used a saturated sample of 30 people. The type of data used is primary data in the form of questionnaires and interviews. This research was conducted at the Micro, Small and Medium Karya Rattan, Central Bengkulu. Results: The study found that the source of capital from Karya Rattan came from their own capital which was established in 2017 amounting to Rp. 7500.000,-. The capital that continues to grow from the sales makes Karya Rattan grow. The resulting products are of high quality and have a long service life, are highly varied and innovative. Through good quality, Rattan works have been able to last for 5 years until now. Limitation: This research is that it only examines 1 Micro, Small and Medium in Central Bengkulu. Its contribution Rattan work has provided economic progress for the Micro, Small and Medium sector, which in addition to increasing its income also has an impact on increasing business in Central Bengkulu. Contribution: Research can increase knowledge about Micro, Small and Medium especially in the furniture sector.
Trait anxiety modulates the detection sensitivity of negative affect in speech
Authors: K Achyuthanand , Prasad Saurabh , CHAKRABARTY MRINMOY
Published: April 2022

Auditory perception
of emotions in speech is relevant for humans to optimally navigate the social environment. While sensory perception is known to
be influenced by bodily internal states such as anxiety and ambient noise,
their relationship on human auditory perception is relatively less understood.
In a supervised, internet-based experiment carried out sans the artificially
controlled laboratory environment, we asked if the detection sensitivity of emotions
conveyed by human speech-in-noise (acoustic signals) is modulated by individual
differences in affective internal states, e.g., anxiety. In a task,
participants (n=24) accurately discriminated the target emotion conveyed
by the temporally unpredictable acoustic signals (signal to noise ratio=10dB),
which were manipulated at four levels (Happy, Neutral, Fear and Disgust). We
calculated empirical area under the curve (measure of acoustic signal detection
sensitivity) based on signal detection theory to quantify our results.
Specifically, Disgust and Fear detection sensitivities worsened with increasing
individual severities of trait-anxiety. Further, a similar effect was evident
when averaging across all four emotions. Altogether, the results suggest that
individual trait-anxiety levels moderate the detection of emotions from
speech-in-noise, especially those conveying negative/threatening affect. The
findings may be relevant for expanding the understanding pertaining to auditory
perception anomalies underlying affective states and disorders
Understanding of AR Technologies
Authors: Sakib S M Nazmuz
Published: April 2022

A lot of progress has
been made in the field of augmented reality tracking over the last few years.
Several dependable tracking systems that provide real-time tracking in an
indoor setting have been developed. As previously stated in this survey report,
there are still some challenges with AR tracking, such as occlusion, varying
lighting environments, variable backdrop contrast, and varying color
intensities. The development of algorithms that use marker-based tracking to
enable robust and accurate tracking in a variety of illumination, contrast, and
lighting conditions will be a future focus.
Flare: An Online Low Complexity Event and Intrusion Detection for Power Transmission Networks
Authors: Wahab Abdul
Published: April 2022

In this paper, we present Flare: a lightweight plug
& play machine learning based Event and intrusion detection
systems (EIDS), which can effectively learn to discriminate among
transmission line faults, contingencies, false data injection (FDI)
and false command injection (FCI) attacks
Analysis on Strickland’s Pursuit in The Moon and Sixpence
Authors: Chen Hongping , Qian Xu
Published: April 2022

The Moon and sixpence is one of the three major novels of the British novelist, Maugham William Somerset. The full paper discusses the remarkable life of Strickland. The paper focuses on Strickland’s pursuit. To begin with, it introduces two major pursuits in Strickland’s life. One of the pursuit is freedom, and another is the pursuit of dreams. These two major pursuits had made great difference on Strickland. He gives up the sixpence that ordinary people yearn for and pursue the moon in his heart. Then the paper analyzes the reasons for the pursuit of freedom and dream and the ways to pursue them. This paper aims at studying Strickland’s life. From his different choices, I analyze the importance of freedom and dreams to everyone and reveals how to make a choice between the moon and sixpence in the novel.
Conflict during COVID-19 Pandemic in Thailand: Causes and Recommendations for Conflict Resolution
Authors: Promsri Chaiyaset , Chaigusin Suchira , Tupmongkol Thanatas
Published: April 2022

The purpose of this article is to identify causes of conflict during COVID-19 pandemic in Thailand and provide some recommendations for conflict resolution. Thai government’s policy measures originate the root causes of conflict during COVID-19 including interdependence, perceived incompatible goals, perceived scarce resources, interference. To decrease conflict escalation, recommendations for conflict resolution are discussed in three levels: government, organization, and individual. This article can be used as a foundation for research development in this area.
Impact of COVID-19 on Tourism and Economy of Pakistan
Authors: Khan Aisha , Naeem Roohi , Khalid Iqra , Qureshi Umme Aiman
Published: April 2022

The virus that triggered a localised shock in China is now delivering a significant global tremor of which Pakistan has also become a victim. This study simulates the potential impact of COVID-19 on tourism and the economic condition of Pakistan. COVID-19 spread rapidly at the end of February 2020 in Pakistan and brought all economic activities on pause. Pakistan is the ideal destination for both local and foreign tourists. The partial lockdown is being imposed to avoid the spread of COVID-19; consequently all businesses, tours, domestic activities and supply chain disrupted and have the notable effect on retail and wholesale trade, transport section and communication the part of the service industry. The outbreak of pandemic COVID-19 in Pakistan can cause a decline in GDP by 1.57% on account of agriculture, travel and tourism, health and business and trade. This exercise is illustrative because it is still too early to make an informed assessment of the full impact of the pandemic. But it does convey the likely extent of impending global economic pain, especially for developing countries and their potential need for assistance.
Agro-industries in Cameroon and Welfare-related Services to Non-labourers in Operational Neighbourhoods: The Case of the Cameroon Development Corporation and the Societe Camerounaise de Palmeraies, 1968 - 2019
Authors: Akara Damian T.
Published: April 2022

The agro-industrial sector in Cameroon remains an important part of the country’s life wire as it produces for both local consumption and export thereby bringing revenue to the country and contributing to the welfare of its citizens. While attention is often drawn to production, the role of labour and the subsequent exportation of raw materials, very little attention is accorded to the auxiliary activities of agro-industrial complexes such as the Cameroon Development Corporation (CDC) and the Societe Camerounaise de Palmeraies (SOCAPALM) towards the socio-economic advancement of the areas or neighbourhoods in which they carried out their operations. This paper accordingly, focuses on the contribution of two important agro-industries in Cameroon, the CDC and SOCAPALM, in the socio-economic welfare of the populations in the vicinities in which they operated. Using a historical method of analysis, it reveals that several persons or groups (non-labourers of the companies) benefitted, and in some instances, even more than the labourers, because of their proximity to the companies’ estates and installations.
Diagnosis of Interpersonal Relationships in Higher Education Students
Authors: Iscander Ramírez Castañeda Armando , Yaraset Mendoza Montero Fátima , Antonio Flores Zamorano Jesús , Ricardo Ricardo García Parada , Astrid Macías Sagarmínaga María Eugenia , Víctor Villar Laguna
Published: April 2022

The present study presents an investigation regarding the diagnosis of interpersonal relationships in higher education students. For the analysis, the instrument suggested by Cisneros (2009) was used. The study had a descriptive and exploratory research level. The sample that was used was 34 students. The results obtained in the research was that the undergraduate students have acceptable self-control and acceptable empathy.
STORAGE OF VEGETABLE PRODUCTS ON FARMS DIRECTIONS FOR THE PROVISION OF SERVICES AND EFFECTIVE METHOD SELECTION CRITERIA
Authors: Farrux Polvonov
Published: April 2022

Ensuring the food security of the country is a multifaceted problem, the solution of which requires a comprehensive approach. It is not enough to produce food raw materials alone, it is necessary to create and maintain logistics chains that are constantly operating efficiently to deliver the grown crop to consumers. The purpose of the study is to develop criteria for the selection of effective methods and directions for the establishment of services for the storage of vegetable products on farms. Research methods include experiment, analysis, modeling, logic, synthesis, induction, deduction, hypothetical, study and oboshchenie, abstragirovanie, idealization, formalization, analysis and synthesis, induction and deduction, axiomatics and others.
KEYWORDS: agro-industrial complex, foreign experience, vegetable products