bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis, Molecular Docking and Biological Characterization of Pyrazine Linked 2-Aminobenzamides as New Class I Selective Histone Deacetylase (HDAC) Inhibitors with Anti-Leukemic Activity
Authors: Ibrahim Hany S. , Abdelsalam Mohamed , Zeyn Yanira , Zessin Matthes , Mustafa Al-Hassan M. , Fischer Marten A. , Zeyen Patrik , Sun Ping , Bülbül Emre F. , Vecchio Anita , Erdmann Frank , Schmidt Matthias , Robaa Dina , Barinka Cyril , Romier Christophe , Schutkowski Mike , Krämer Oliver H. , Sippl Wolfgang
Published: December 2021

Class I histone deacetylases (HDACs) are key regulators of cell proliferation and they are frequently dysregulated in cancer cells. We report here the synthesis of a novel series of class-I selective HDAC inhibitors (HDACi) containing a 2-aminobenzamide moiety as a zinc-binding group connected with a central (piperazin-1-yl)pyrazine or (piperazin-1-yl)pyrimidine moiety. Some of the compounds were additionally substituted with an aromatic capping group. Compounds were tested in vitro against human HDAC1, 2, 3, and 8 enzymes and compared to reference class I HDACi (Entinostat (MS-275), Mocetinostat, CI994 and RGFP-966). The most promising compounds were found to be highly selective against HDAC1, 2 and 3 over the remaining HDAC subtypes from other classes. Molecular docking studies and MD simulations were performed to rationalize the in vitro data and to deduce a complete structure activity relationship (SAR) analysis of this novel series of class-I HDACi. The most potent compounds, including 19f, which blocks HDAC1, HDAC2, and HDAC3, as well as the selective HDAC1/HDAC2 inhibitors 21a and 29b, were selected for further cellular testing against human acute myeloid leukemia (AML) and erythroleukemic cancer (HEL) cells, taking into consideration their low toxicity against human embryonic HEK293 cells. We found that 19f is superior to the clinically tested class-I HDACi Entinostat (MS-275). Thus, 19f is a new and specific HDACi with the potential to eliminate blood cancer cells of various origins.
Animal Model for Glucocorticoid Induced Osteoporosis: A Systematic Review from 2011 to 2021
Authors: Xavier Andy , Toumi Hechmi , Lespessailles Eric
Published: December 2021

Clinical and experimental data have shown that prolonged exposure to GCs leads to bone loss and increases fracture risk. Special attention has been given to existing emerging drugs that can prevent and treat glucocorticoid-induced osteoporosis GIOP. However, there is no consensus about the most relevant animal model treatments on GIOP. In this systematic review, we aimed to examine animal models of GIOP centering on study design, drug dose, timing and size of the experimental groups, allocation concealment, and outcome measures. The present review was written according to the PRISMA 2020 statement. Literature searches were performed in the PubMed electronic database via Mesh with the publication date set between April, 2011, and February 2021. A total of 284 full-text articles were screened and 53 were analyzed. The most common animal species used to model GIOP were rats (66%) and mice (32%). In mice studies, males (58%) were preferred and genetically modified animals accounted for 28%. Our work calls for a standardization of the establishment of the GIOP animal model with better precision for model selection. A described reporting design, conduction, and selection of outcome measures are recommended.
Interlaboratory Comparison as a Source of Information for the Product Evaluation Process. Case Study of Ceramic Tiles Adhesives
Authors: Stancu Cristina , Michalak Jacek
Published: December 2021

In this study, the results obtained by 19 laboratories participating in 2 editions of the interlaboratory comparison (ILC) determining 2 properties of ceramic tiles adhesives (CTAs), i.e., initial tensile adhesion strength and tensile adhesion strength after water immersion following EN 12004, were analyzed. The results show that participating laboratories maintain a constant quality of their work. The use of z-score analysis, under ISO 13528, allows for classifying 89.5% to 100% of laboratories as satisfactory, depending on the measurement’s kind and edition. The remaining laboratories are classified as questionable. The investigation of the predominant mode of failure of the CTA’s samples tested in the two editions shows significant differences. From the perspective of laboratories, the goal of the ILC has been achieved. From the standpoint of a manufacturer who evaluates a product’s properties when placing it on the market, the results indicate the necessity of a particular treatment of the product evaluation process because the variability of the obtained results is significant. It increases the possibility of the product failing to meet the assessment criteria verified by the construction market supervision authorities. The manufacturer must consider all possible variations in the risk analysis, including the ILC results, to improve the assessment process of CTAs.
The Corrosion Resistance and Mechanism of AT13/Fe-Based Amorphous Composite Coatings
Authors: Chu Zhenhua , Teng Shikun , Zhou Yuyun , Zheng Xingwei , Xu Jingxiang , Wang Fang , Zhang Baosen
Published: December 2021

Due to high strength, high wear resistance and high corrosion resistance, the amorphous metallic glasses were investigated widely. In the present study, the corrosion resistance of amorphous coating and composite coatings with various proportions of AT13 (Al2O3–13 wt.% TiO2) ceramic as additions in 3.5 wt.% NaCl solution were studied. The corrosion resistance was improved obviously as the addition of AT13, and when the content of AT13 was 15 wt.%, the composite coating had the lowest corrosion current density (1.75 × 10−6 A cm−2) and the highest corrosion potential (−411 mV), which was 5.14 × 10−5 A cm−2 and −580 mV for Fe-based metallic glassy coating, respectively. The corrosion mechanism was proposed according to the long-time immersion corrosion test.
Root-Associated Entomopathogenic Fungi Modulate Their Host Plant’s Photosystem II Photochemistry and Response to Herbivorous Insects
Authors: Moustaka Julietta , Meyling Nicolai Vitt , Hauser Thure Pavlo
Published: December 2021

The escalating food demand and loss to herbivores has led to increasing interest in using resistance-inducing microbes for pest control. Here, we evaluated whether root-inoculation with fungi that are otherwise known as entomopathogens improves tomato (Solanum lycopersicum) leaflets’ reaction to herbivory by Spodoptera exigua (beet armyworm) larvae using chlorophyll fluorescence imaging. Plants were inoculated with Metarhizium brunneum or Beauveria bassiana, and photosystem II reactions were evaluated before and after larval feeding. Before herbivory, the fraction of absorbed light energy used for photochemistry (ΦPSII) was lower in M. brunneum-inoculated than in control plants, but not in B. bassiana-inoculated plants. After herbivory, however, ΦPSII increased in the fungal-inoculated plants compared with that before herbivory, similar to the reaction of control plants. At the same time, the fraction of energy dissipated as heat (ΦNPQ) decreased in the inoculated plants, resulting in an increased fraction of nonregulated energy loss (ΦNO) in M. brunneum. This indicates an increased singlet oxygen (1O2) formation not detected in B. bassiana-inoculated plants, showing that the two entomopathogenic fungi differentially modulate the leaflets’ response to herbivory. Overall, our results show that M. brunneum inoculation had a negative effect on the photosynthetic efficiency before herbivory, while B. bassiana inoculation had no significant effect. However, S. exigua leaf biting activated the same compensatory PSII response mechanism in tomato plants of both fungal-inoculated treatments as in control plants.
Effect of Multi-Year Environmental and Meteorological Factors on the Quality Traits of Winter Durum Wheat
Authors: Vida Gyula , Cséplő Mónika , Rakszegi Marianna , Bányai Judit
Published: December 2021

A detailed study was made of the effect of rainfall, average temperature and hot days on the gluten index and Minolta b* value of winter durum wheat sown in the field in 16 consecutive crop years (2005–2020). The joint analysis of these two technological quality traits represented a complex (plant–environment–meteorological factors) approach for the identification of durum wheat cultivars carrying an optimum combination of the two traits and for the determination of quality stability. The results of GGE-biplot analysis indicated that the cultivar that had the most favorable combination of the traits was ‘MVP’, while cultivar ‘GKS’ had the best gluten strength and ‘MVH’ the best yellow pigment content. Correlation analysis and stepwise regression between various meteorological factors (rainfall, mean temperature, number of heat days per 10-day period during grain-filling) and the two technological quality traits indicated that the expected value of the quality traits could be reliably estimated based on meteorological factors, with a generally negative effect on gluten index and a positive one on yellowness in all cultivars.
Effect of Printing Process Parameters on the Shape Transformation Capability of 3D Printed Structures
Authors: Pivar Matej , Gregor-Svetec Diana , Muck Deja
Published: December 2021

The aim of our research was to investigate and optimise the main 3D printing process parameters that directly or indirectly affect the shape transformation capability and to determine the optimal transformation conditions to achieve predicted extent, and accurate and reproducible transformations of 3D printed, shape-changing two-material structures based on PLA and TPU. The shape-changing structures were printed using the FDM technology. The influence of each printing parameter that affects the final printability of shape-changing structures is presented and studied. After optimising the 3D printing process parameters, the extent, accuracy and reproducibility of the shape transformation performance for four-layer structures were analysed. The shape transformation was performed in hot water at different activation temperatures. Through a careful selection of 3D printing process parameters and transformation conditions, the predicted extent, accuracy and good reproducibility of shape transformation for 3D printed structures were achieved. The accurate deposition of filaments in the layers was achieved by adjusting the printing speed, flow rate and cooling conditions of extruded filaments. The shape transformation capability of 3D printed structures with a defined shape and defined active segment dimensions was influenced by the relaxation of compressive and tensile residual stresses in deposited filaments in the printed layers of the active material and different activation temperatures of the transformation.
Monitoring Cropland Phenology on Google Earth Engine Using Gaussian Process Regression
Authors: Salinero-Delgado Matías , Estévez José , Pipia Luca , Belda Santiago , Berger Katja , Paredes Gómez Vanessa , Verrelst Jochem
Published: December 2021

Monitoring cropland phenology from optical satellite data remains a challenging task due to the influence of clouds and atmospheric artifacts. Therefore, measures need to be taken to overcome these challenges and gain better knowledge of crop dynamics. The arrival of cloud computing platforms such as Google Earth Engine (GEE) has enabled us to propose a Sentinel-2 (S2) phenology end-to-end processing chain. To achieve this, the following pipeline was implemented: (1) the building of hybrid Gaussian Process Regression (GPR) retrieval models of crop traits optimized with active learning, (2) implementation of these models on GEE (3) generation of spatiotemporally continuous maps and time series of these crop traits with the use of gap-filling through GPR fitting, and finally, (4) calculation of land surface phenology (LSP) metrics such as the start of season (SOS) or end of season (EOS). Overall, from good to high performance was achieved, in particular for the estimation of canopy-level traits such as leaf area index (LAI) and canopy chlorophyll content, with normalized root mean square errors (NRMSE) of 9% and 10%, respectively. By means of the GPR gap-filling time series of S2, entire tiles were reconstructed, and resulting maps were demonstrated over an agricultural area in Castile and Leon, Spain, where crop calendar data were available to assess the validity of LSP metrics derived from crop traits. In addition, phenology derived from the normalized difference vegetation index (NDVI) was used as reference. NDVI not only proved to be a robust indicator for the calculation of LSP metrics, but also served to demonstrate the good phenology quality of the quantitative trait products. Thanks to the GEE framework, the proposed workflow can be realized anywhere in the world and for any time window, thus representing a shift in the satellite data processing paradigm. We anticipate that the produced LSP metrics can provide meaningful insights into crop seasonal patterns in a changing environment that demands adaptive agricultural production.
Wearable E-Textile and CNT Sensor Wireless Measurement System for Real-Time Penile Erection Monitoring
Authors: Heo Yongki , Kim Jinhyung , Cha Cheolung , Shin Kyusik , Roh Jihyoung , Jo Jungki
Published: December 2021

Erection measurements are the most important indicator of male urological disease diagnosis, treatment, and results. Rigiscan has been used widely in studies and diagnoses for nocturnal penile tumescence for evaluating erectile dysfunction by measuring the number and timing of erectile dysfunctions during sleep. However, this device has limitations such as the weight and bulk of the device and has been questioned for its role as a standard for ED Erectile Dysfunction (ED) diagnosis. In this study, we propose a real-time wearable monitoring system that can quantitatively measure the length and circumference of the penis using electronic textiles (E-textile) and carbon nanotube (CNT) sensors. The E-textile sensor is used to measure the length, circumference, and gradient with portability, convenience, and comfort. Sensors were created by coating CNTs on latex for flexibility. The CNT-based latex condom-type sensor in our proposed system shows the length, circumference, and curvature measurements with changes in resistance, and the E-textile performance shows a 1.44% error rate and a cavity radius of 110 to 300. The results of this conceptual study are for supplementary sensor development with a combination of new technologies with alternatives or existing methods for measuring erection function.
Application of Wigner Distribution Function for THz Propagation Analysis
Authors: Gerasimov Michael , Dyunin Egor , Gerasimov Jacob , Ciplis Johnathan , Friedman Aharon
Published: December 2021

The construction of a transmission line (TL) for a wide tunable broad-spectrum THz radiation source is not a simple task. We present here a platform for the future use of designs of the TL through our homemade simulations. The TL is designed to be a component of the construction of an innovative accelerator at the Schlesinger Family Center for Compact Accelerators, Radiation Sources and Applications (FEL). We developed a three-dimensional space-frequency tool for the analysis of a radiation pulse. The total electromagnetic (EM) field on the edge of the source is represented in the frequency domain in terms of cavity eigenmodes. However, any pulse can be used regardless of its mathematical function, which is the key point of this work. The only requirement is the existence of the original pulse. This EM field is converted to geometric-optical ray representation through the Wigner transform at any desired resolution. Wigner’s representation allows us to describe the dynamics of field evolution in future propagation, which allows us to determine an initial design of the TL. Representation of the EM field by rays gives access to the ray tracing method and future processing, operating in the linear and non-linear regimes. This allows for fast work with graphics cards and parallel processing, providing great flexibility and serving as future preparation that enables us to apply advanced libraries such as machine learning. The platform is used to study the phase-amplitude and spectral characteristics of multimode radiation generation in a free-electron laser (FEL) operating in various operational parameters.
Stabilization of the Cart–Inverted-Pendulum System Using State-Feedback Pole-Independent MPC Controllers
Authors: Messikh Lotfi , Guechi El-Hadi , Blažič Sašo
Published: December 2021

In this paper, a pole-independent, single-input, multi-output explicit linear MPC controller is proposed to stabilize the fourth-order cart–inverted-pendulum system around the desired equilibrium points. To circumvent an obvious stability problem, a generalized prediction model is proposed that yields an MPC controller with four tuning parameters. The first two parameters, namely the horizon time and the relative cart–pendulum weight factor, are automatically adjusted to ensure a priori prescribed system gain margin and fast pendulum response while the remaining two parameters, namely the pendulum and cart velocity weight factors, are maintained as free tuning parameters. The comparison of the proposed method with some optimal control methods in the absence of disturbance input shows an obvious advantage in the average peak efficiency in favor of the proposed SIMO MPC controller at the price of slightly reduced speed efficiency. Additionally, none of the compared controllers can achieve a system gain margin greater than 1.63, while the proposed one can go beyond that limit at the price of additional degradation in the speed efficiency.
A Literature Review of Drone-Based Package Delivery Logistics Systems and Their Implementation Feasibility
Authors: Benarbia Taha , Kyamakya Kyandoghere
Published: December 2021

In recent years, e-commerce businesses have seen an increase in the daily volume of packages to be delivered, as well as an increase in the number of particularly demanding customer expectations. In this respect, the delivery mechanism became prohibitively expensive, particularly for the final kilometer. To stay competitive and meet the increased demand, businesses began to look for innovative autonomous delivery options for the last mile, such as autonomous unmanned aerial vehicles/drones, which are a promising alternative for the logistics industry. Following the success of drones in surveillance and remote sensing, drone delivery systems have begun to emerge as a new solution to reduce delivery costs and delivery time. In the coming years, autonomous drone sharing systems will be an unavoidable logistical solution, especially with the new laws/recommendations introduced by the Flight World Organization on how to organize the operations of these special unmanned airline systems. This paper provides a comprehensive literature survey on a set of relevant research issues and highlights the representative solutions and concepts that have been proposed thus far in the design and modeling of the logistics of drone delivery systems, with the purpose of discussing the respective performance levels reached by the various suggested approaches. Furthermore, the paper also investigates the central problems to be addressed and briefly discusses and outlines a series of interesting new research avenues of relevance for drone-based package delivery systems.
I267L Is Neither the Virulence- Nor the Replication-Related Gene of African Swine Fever Virus and Its Deletant Is an Ideal Fluorescent-Tagged Virulence Strain
Authors: Zhang Yanyan , Ke Junnan , Zhang Jingyuan , Yue Huixian , Chen Teng , Li Qian , Zhou Xintao , Qi Yu , Zhu Rongnian , Wang Shuchao , Miao Faming , Zhang Shoufeng , Li Nan , Mi Lijuan , Yang Jinjin , Yang Jinmei , Han Xun , Wang Lidong , Li Ying , Hu Rongliang
Published: December 2021

African swine fever virus (ASFV) is the causative agent of African swine fever (ASF) which reaches up to 100% case fatality in domestic pigs and wild boar and causes significant economic losses in the swine industry. Lack of knowledge of the function of ASFV genes is a serious impediment to the development of the safe and effective vaccine. Herein, I267L was identified as a relative conserved gene and an early expressed gene. A recombinant virus (SY18ΔI267L) with I267L gene deletion was produced by replacing I267L of the virulent ASFV SY18 with enhanced green fluorescent protein (EGFP) cassette. The replication kinetics of SY18ΔI267L is similar to that of the parental isolate in vitro. Moreover, the doses of 102.0 TCID50 (n = 5) and 105.0 TCID50 (n = 5) SY18ΔI267L caused virulent phenotype, severe clinical signs, viremia, high viral load, and mortality in domestic pigs inoculated intramuscularly as the virulent parental virus strain. Therefore, the deletion of I267L does not affect the replication or the virulence of ASFV. Utilizing the fluorescent-tagged virulence deletant can be easy to gain a visual result in related research such as the inactivation effect of some drugs, disinfectants, extracts, etc. on ASFV.
Biophysical Characterization of Viral and Lipid-Based Vectors for Vaccines and Therapeutics with Light Scattering and Calorimetric Techniques
Authors: Markova Natalia , Cairns Stefan , Jankevics-Jones Hanna , Kaszuba Michael , Caputo Fanny , Parot Jérémie
Published: December 2021

Novel vaccine platforms for delivery of nucleic acids based on viral and non-viral vectors, such as recombinant adeno associated viruses (rAAV) and lipid-based nanoparticles (LNPs), hold great promise. However, they pose significant manufacturing and analytical challenges due to their intrinsic structural complexity. During product development and process control, their design, characterization, and quality control require the combination of fit-for-purpose complementary analytical tools. Moreover, an in-depth methodological expertise and holistic approach to data analysis are required for robust measurements and to enable an adequate interpretation of experimental findings. Here the combination of complementary label-free biophysical techniques, including dynamic light scattering (DLS), multiangle-DLS (MADLS), Electrophoretic Light Scattering (ELS), nanoparticle tracking analysis (NTA), multiple detection SEC and differential scanning calorimetry (DSC), have been successfully used for the characterization of physical and chemical attributes of rAAV and LNPs encapsulating mRNA. Methods’ performance, applicability, dynamic range of detection and method optimization are discussed for the measurements of multiple critical physical−chemical quality attributes, including particle size distribution, aggregation propensity, polydispersity, particle concentration, particle structural properties and nucleic acid payload.
Wind-Induced Resuspension and Transport of Contaminated Sediment from the Rove Canal into the Etang De Berre, France
Authors: Alekseenko Elena , Roux Bernard , Kuznetsov Konstantin
Published: December 2021

The present study concerns the erosion and transport of severely contaminated sediments in a Canal. It begins in the context of an engineering project aimed to re-introduce a forced convection at the entrance of this Canal by pumping marine water. The local wind is often strong enough to overpass the resuspension threshold; thus, there is a serious risk of downstream contamination of a Mediterranean lagoon. So, the goal is to evaluate this risk as a function of the pumping rate; this contamination is transported by the fine suspended particles. Different scenarios are investigated to determine the downstream transport of suspensions in terms of runoff. These scenarios (of 24 h) contains a succession of 3 periods: constant wind speed, wind slowdown and calm, for two opposite wind directions. Special attention is devoted to the modeling of complex mechanisms of erosion and resuspension during wind periods, deposition during windless periods and sediment consolidation. The main results concern the total flux of the suspended particles through the exit of the Canal at the confluence with the lagoon. It is shown that even for moderate runoff (<6 m3/s) this total flux is large enough, not only during the wind period, but also after several hours of calm.
ОСОБЛИВОСТІ СТАНОВЛЕННЯ І РОЗВИТКУ НАЦІОНАЛЬНОГО ТЕАТРУ В ТАБОРАХ ІНТЕРНОВАНИХ ВОЯКІВ-УКРАЇНЦІВ АРМІЇ УНР У ПОЛЬЩІ, 1921 р.
Authors: Палієнко Марина Геннадіївна , Срібняк Ігор Володимирович
Published: December 2021

У статті проаналізовано процес становлення та розвитку українського національного театру в таборах інтернованих вояків-українців у Польщі впродовж 1921 р. У цей час театр залишався однією з найважливіших ланок культурно-освітньої та патріотично-виховної роботи в таборах, скріплюючи національно-державницькі прагнення інтернованого вояцтва. Таборовий театр став місцем, де інтерновані вояки-українці шукали і знаходили оригінальне вираження власним мистецьким пошукуванням, роблячи в такий спосіб свій внесок у скарбницю українського та європейського драматичного мистецтва
ЖАНРОВІ ОСОБЛИВОСТІ ПРОБЛЕМНОЇ СТАТТІ У ТЕАТРАЛЬНІЙ КРИТИЦІ 1970–1980-х РОКІВ (ЗА МАТЕРІАЛАМИ ЖУРНАЛУ «УКРАЇНСЬКИЙ ТЕАТР»)
Authors: Бубнова Вікторія Вікторівна
Published: December 2021

У статті проаналізовано жанр театральної критики – проблемну статтю у період 1970– 80‑х рр. Аналіз спирається на публікації у центральному професійному театральному виданні –журналі «Український театр». Визначені основні автори, запропонована типологія: статті у річищі політичної кампанії (пропагандистські), статті-висловлювання, статті теоретичні/історико-теоретичні, інтерв’ю з практиками театру на гостру тему, статті полемічні (дискусійні).
СИМВОЛІКА СТИХІЙ ЯК СМИСЛОУТВОРЮЮЧИЙ ФАКТОР У КІНЕМАТОГРАФІ
Authors: Мусієнко Оксана Станіславівна
Published: December 2021

Метою статті є дослідження впливів символіки природних стихій на образну систему аудіовізуальних мистецтв, кінематографа зокрема. Авторка аналізує фільми, де ці впливи проявилися найбільш виразно, а саме твори О.Довженка, Ж.Віго, Ф. Фелліні, А.Тарковського, Ю. Іллєнка
ВИДОВИЩНІ ФОРМИ У СУЧАСНІЙ КУЛЬТУРІ
Authors: Станіславська Катерина Ігорівна
Published: December 2021

Предмет статті – видовищні форми сучасної культури як маркер постмодерністського мистецтва. Постмодерн представлений як епоха зміни парадигми через візуальні та тілесні повороти. Візуальні та тілесні домінанти показані як провідні властивості сучасних видовищних форм. Висновки узагальнюють домінування видовищності в сучасній культурі, здатність сучасної людини реалізувати себе в ролях глядача та учасника видовищних форм.
ТЕОРЕТИКО-МЕТОДОЛОГІЧНІ ОСНОВИ ФОРМУВАННЯ І РОЗВИТКУ КРЕАТИВНИХ КЛАСТЕРІВ В УКРАЇНІ: КУЛЬТУРОЛОГІЧНИЙ ПІДХІД
Authors: Плецан Христина Василівна
Published: December 2021

У дослідженні розкрито теоретико-методологічні підходи до визначення сутності креативних кластерів. У історичній ретроспективі проаналізовано українську практику формування і розвитку кластеризації креативних індустрій. Виокремлено основні ознаки, принципи, структурно- функціональні особливості організації та діяльності креативних кластерів. Доведено, що колоборація творчих товарів і послуг сприяє формуванню нових соціокультурних проявів на основі людиноцентризму. Доведено, що формування і розвиток креативних кластерів сприятиме культурно-творчій активності представників креативних індустрій, посиленню суспільної згуртованості, популяризації культурних цінностей, підвищенню громадянської гордості й рівня культури загалом. Теоретична основа, що вико- ристовується в статті, ґрунтується на культурологічному підході.
ВІД АВАНГАРДИЗМУ ДО «РЕАЛІЗМУ БЕЗ БЕРЕГІВ»: МОДИФІКАЦІЇ ФІЛОСОФСЬКОГО «ЗАБЕЗПЕЧЕННЯ» ФРАНЦУЗЬКОГО КУЛЬТУРОТВОРЕННЯ
Authors: Холодинська Світлана Миколаївна
Published: December 2021

Матеріал статті відтворює процес становлення низки формалістичних або «не-реалістичних» напрямів у французькому мистецтві початку ХХ століття, що були об’єднані поняттям «авангардизм» і викликали достатньо гострі дискусії стосовно перспектив реалізму, який упродовж другої половини ХІХ століття мав вагомі позиції в літературі, живописі та театрі Франції. У зв’язку з означеним, актуалізується як низка теоретичних проблем, так і доцільність – з сучасного погляду – оцінити здобутки та прорахунки тогочасної практики французького мистецтва.
ВИКОРИСТАННЯ РЕГІОНАЛЬНО-МОВЛЕННЄВИХ ВИСЛОВЛЮВАНЬ У НАВЧАЛЬНІЙ ПРАКТИЦІ
Authors: Сухорукова Карина Сергіївна
Published: December 2021

Розглянуто використання регіонально-мовленнєвих висловлювань у навчальній практиці майбутніми акторами драматичного театру. Вказано на доцільність освоєння літературної вимови як чинника у формуванні трансформаційних перетворень в усній українській сценічній мові. Сформульовано визначення «Регіонально-мовленнєві висловлювання» в контексті слова на сцені та запропоновано науково-творчий метод щодо оволодіння вимовою з діалектною лексикою. Зроблено оглядовий аналіз мовного образу вистави «Буна», а також деталізований розбір фонологічного портрета на прикладі аналізу роботи виконавиці головної ролі
Language, culture, and image-driven interpretations in translation: A case for the university translation classroom in Ukraine
Authors: Vakhovska Olha , Isaienko Olha
Published: December 2021

In this paper, we develop a theory of image-driven interpretations for the translation studies domain. Interpretations make the core of translation and are explained in terms of mental images. An image-driven interpretation gives a meaning to a source-language word and finds in the target language the word to capture this meaning, which is a creative act and a cross-cultural transfer. An interpretation is ‘drawing’ images in the human mind by the powers of the mind’s representational content.

Our theory proposes a role for etymological insight in boosting translation students’ interpretive skills via exposed inner word forms. These archaic archetypal images contain culture-specific information transmitted through human generations with the help of language. Inner word forms are non-trivial triggers in cultural exposure that raise students’ awareness of the native and foreign cultures and add an in-depth dimension to regular vocabulary work and other good practices in the translation classroom. We pin down some of the influences that native Ukrainian words and borrowings have had on the Ukrainians’ interpretive mind.
"But Why No Women Write, I Pray?" Sarah Jinner’s Defence of Women’s Public Voice in Her Almanacs
Authors: Oliveira Susana
Published: December 2021

In seventeenth century England women writers had already been able to move beyond the two genres of writing that had initially been approved for them: translation and devotional literature. It is noteworthy, however, to acknowledge women as authors of almanacs, considering that these writings required a scientific background based upon a specific education in medicine and astrology usually inaccessible to women. Between 1658 and 1664, Sarah Jinner emerged as the first woman author of almanacs. Besides the anticipated prophecies and medical advice, this London astrologer also advocated women’s public voice in her works: “But why no women write, I pray?” Jinner used these popular and widely read Early Modern English texts to publicise her defence of women. This paper focuses on Jinner’s open challenge to the Aristotelian perspective on women and her defence of women’s public voice.
PRELIMINARY RESEARCH ON SOME MORPHOMETRIC CHARACTERISTICS OF EUROPEAN RED WOOD ANTS (FORMICA PRATENSIS RETZIUS, 1783) ALONG THE TURKEY-BULGARIA CROSS-BORDER AREA
Authors: ÇAMLITEPE Yılmaz , AKSOY Volkan , LAPEVA-GJONOVA Albena , YENCE Kaan , DUMLU Cansu , GJONOV Ilia
Published: December 2021

Formica pratensis (Hymenoptera: Formiciadae) is one of the members of the wood ants group and is represented in Europe with the hairy N morph common in the south and the less hairy P morph common in the north. The species is naturally distributed in European part of Turkey (Thrace Region) and in the neighboring parts of Bulgaria. Former studies of Bernhard Seifert showed that the N morph is the dominant morph in south Bulgaria, but the situation in Turkey is not known. In the present study, we sampled workers from some colonies of F. pratensis in Turkey and Bulgaria and obtained a pilosity data for each colony in the two countries. The comparison of our data with that of Seifert showed that the Bulgaria samples well fit with the pilosity data of P morph and Turkey samples were apparently less hairy but hairs are longer than all other populations. The results helped us to show that F. pratensis can have ecomorphological traits other than that fitting the definition of N and P morphs and that traits may differ from one to another population distributed even along in a small scale of area.
Kathi fits in Tamil Paattiyal Grammar Text
Authors: G Lakshmidevi , S Rajaram
Published: December 2021

Tamil Pattiyal Grammar Works are Grammatial text (Sitrilakkiyam) for literature that originated from the lives of Tamil Speaking people. Pattiyal Grammar text are thought to be an alternative to the long-time grammatical tradition. Follow such a tradition Tamil Paattiyal Grammar state the monolingual principles for the four types of births of the god, people, naragar, animal. These grammar text created a unique identity for itself. This is because of the authors of the book wrote their own ideas as grammatical principles. This is the Hypothesis of the article. This review article is based on the criteria for Descriptive performance, Sociological performance and Comparative performance.
MANAGEMENT OF SYSTEMIC PROBLEMS COMPETITIVE ADVANTAGES AS AN EFFECTIVE TOOL FOR INCREASING THE INNOVATIVE DEVELOPMENT OF STATE CORPORATIONS
Authors: Эльгукаева Л. А. , Муртазаева А. С-А.
Published: December 2021

Последние двадцать лет было предпринято немало усилий для активизации инновационной деятельности в стране. Тем не менее, статистические материалы ФСГС РФ свидетельствуют, что ожидаемые результаты в виде значимого роста инновационной составляющей ВВП и объемов реализации российских инновационных продуктов на международных рынках так и остались нереализованными. Бесспорно, все это актуализирует необходимость поиска современных подходов, точек роста инновационного развития. В первую очередь, речь идет о государственных высокотехнологичных корпорациях. Именно в них создаются новые знания, появляются новые компетенции, развиваются прорывные производственные технологии и др. Для мировой экономики характерно циклическое развитие, активный рост всегда сменяется стагнацией, кризисом. Вместе с тем, даже во время острейшего кризиса путем трансформации структуры экономики и рынка можно получить дополнительные возможности для экономического рывка и захвата новых рынков для своих продуктов. Очевидно, что все это сопряжено с решением комплекса задач: корпорациям необходимо оптимизировать свой организационный дизайн, реализовать эффективное стратегическое управление, направленное на укрепление позиций на соответствующих рынках, наращивать конкурентные преимущества и т. п.

Over the past twenty years, a lot of efforts have been made to spur innovation in the country. Nevertheless, the statistical materials of the Federal State Statistics Service of the Russian Federation indicate that the expected results in the form of a significant increase in the innovation component of GDP and the volume of sales of Russian innovative products in international markets remained unrealized.Undoubtedly, all this actualizes the need to search for modern approaches, points of growth for innovative development. First of all, we are talking about state high-tech corporations. It is in them that new knowledge is created, new competencies appear, breakthrough production technologies are developed, etc.The world economy is characterized by cyclical development, active growth is always replaced by stagnation, crisis…At the same time, even during the most acute crisis by transforming the structure of the economy and the market, you can get additional opportunities for an economic breakthrough and capture new markets for your products.It is clear that all this is associated with solving a set of tasks: corporations need to optimize their organizational design, implement effective strategic management aimed at strengthening positions in the relevant markets, increase competitive advantages, etc. All this prompted us to take up the stated research topic.
THE NEED TO DEVELOP PROTECTIVE MEASURES TO MAINTAIN AND SUSTAINABLE FUNCTIONING OF THE BANKING ECOSYSTEM IN RUSSIA
Authors: Магомаева Л. Р. , Абдурахманова М. М. , Магомаев Т. Р.
Published: December 2021

В условиях активного развития экосистем и сближения финансового и нефинансового секторов особую важность приобретает не только качество используемых сервисов, но и контроль за их функционированием на уровне операционных офисов и внутренних структурных подразделений банков. Стратегически важным приоритетом современного банковского сектора выступает поиск новых информационных взаимосвязей, генерирующих не только конкурентные преимущества, но изменение профиля операционных рисков в условиях увеличения объема дистанционных услуг, характера и объемов их предоставления на уровне экосистемы.Развитие глобальных экосистем актуализирует проблемы защиты банковской системы ввиду растущих операционных рисков, оказывающих влияние на капитал. В этой связи целью данной публикации выступает поиск комплексных информационных индикаторов, способных оказать превентивное воздействие на снижение операционных потерь для банков в условиях рисков и неопределенности внешней и внутренней среды.

In the context of the active development of ecosystems and the convergence of the financial and non- financial sectors, not only the quality of the services used, but also control over their functioning at the level of operational offices and internal structural divisions of banks, is of particular importance.A strategically important priority of the modern banking sector is the search for new information relationships that generate not only competitive advantages, but also a change in the profile of operational risks in the face of an increase in the volume of remote services, the nature and volume of their provision at the ecosystem level.The development of global ecosystems actualizes the problems of protecting the banking system in view of growing operational risks affecting capital.In this regard, the purpose of this publication is to search for complex information indicators that can have a preventive effect on reducing operating losses for banks in the face of risks and uncertainty in the external and internal environment.
INFLUENCE OF INFLATION PROCESSES ON FINANCIAL RESULTS OF ACTIVITIES OF A BUSINESS ENTITY
Authors: Абубакарова Ф.Ш. , Геиева Л.А.
Published: December 2021

В статье использована методика расчета показателей финансовой отчетности компании с целью оценки ее деятельности в условиях инфляции. Учет инфляции на финансовые результаты хозяйствующих субъектов важен для повышения топ-менеджментом управленческих решений. Для проведения анализа выявлены основные финансовые показатели. Базой методики анализа влияния инфляции на финансовые результаты, предложенной в статье, явилась разбивка активов и обязательств на денежные и неденежные. При анализе применена модель баланса прироста/ снижения активов и пассивов Ендовицкого Д.А. В качестве объекта исследования выбраны финансовые показатели ОАО «Грознефть».

The article uses the methodology for calculating the indicators of the company’s financial statements in order to assess its activities in the context of inflation. Accounting for inflation on the financial results of business entities is important to improve management decisions by top management. For the analysis, the main financial indicators were identified. The basis of the methodology for analyzing the impact of inflation on financial results, proposed in the article, was the breakdown of assets and liabilities into monetary and non-monetary. In the analysis, the model of the balance of increase / decrease in assets and liabilities of Endovitskiy D. A. was applied. Financial indicators of OJSC “Grozneft” were selected as the object of research.
The effect of iron dextran injection on oral candidiasis symptoms in experimental iron deficiency anemia of laboratory rats
Authors: Rashak Saad Jaafar , Thamer Sanaa Jameel , Alsaadoon Abdullah H. , Ibrahim Maha Khalil
Published: December 2021

Iron deficiency anemia (IDA) is the most common type of anemia that causes various health problems and is commonly companied by oral symptoms, including oral thrush from Candida infection. The study assessed the role of iron status in the pathogenicity of oral candidiasis in an animal model. IDA in rats was produced by feeding on iron-free diet (five weeks), followed by inducing oral candidiasis by Candida albicans suspension. After the infection, animal subgroups were treated by intramuscular injection (IM) of iron dextran (ID) at 2 and 4 mg/kg once a week for three weeks and normal saline injection for comparison. Blood parameters test and tongue histopathological study were conducted. The IDA parameters and the oral thrush lesions were detected in experimental rats. IM of 2 mg ID diminished oral white patches and improved blood hemoglobin (14.533 g/dl), serum iron (109.177 μg/dl), and serum ferritin (5.276 ng/ml) and decreased total iron-binding capacity (377.000 μg/dl). Tongue sections showed normal tongue papillae, reduced inflammation and regular keratin deposition on papillae. At a 4 mg dose, despite the improvement in the blood parameters, a mild reduction was found in tongue thrush by less normal appearance of tongue papillae sections, mild inflammatory cells and hyperplasia of squamous epithelium. The study findings indicate that iron status plays a critical role in the treatment of oral thrush infection.
Bor Katkılı ZnO Nanopartiküllerin Sentezi ve Yapısal, Morfolojik, Optik Özelliklerinin Deneysel/Kuramsal İncelenmesi
Authors: KAYA Yunus , BAYDIR Enver , ARAS Ömür
Published: December 2021

Bu çalışmada, sprey piroliz yöntemi ile farklı molar oranlarda (%0, 0.2, 0.5, 1, ve 2) bor katkılı ZnO nanoparçacıkları elde edilmiştir. Katkısız ve katkılı ZnO nanoparçacıklarının karakterizasyonu, X-ışını kırınımı (XRD) tekniği, yüzey morfolojisi Taramalı Elektron Mikroskobu (SEM) ve optik özellikler ultraviyole-görünür bölge spektrumu ölçülerek yapılmıştır. XRD analiz sonuçları, wurtzite kristal yapıda ZnO nanoparçacıklarının elde edildiğini göstermektedir. Bant aralığı enerjisi (Eg) her bir numune için 2.98 –3.15 eV aralığında bulunmuş ve katkı maddelerinin bant enerjisini artırdığı gözlemlenmiştir. Ayrıca 10 metal ve oksijen atomundan oluşan küme yapıları yarı deneysel/pm6 yöntemi ile optimize edilmiş, kuramsal band boşluğu enerjisi hesaplanmıştır.
Orta Ölçekli Bir Şehirde Kentsel Su Yönetimi: Amasya İli Merzifon İlçesi Örneği
Authors: TUNA Mustafa , ARMUT Selim
Published: December 2021

Bu çalışmada orta ölçekli bir şehirde kentsel su yönetiminin incelenerek suyun kaynaktan alınıp içme suyu iletim ve dağıtım hatlarıyla hizmete sunulması, atık suyun arıtılarak ekolojik ortama deşarj edilmesindeki süreçlerde oluşan sorunlar ele alınmıştır. Bu kapsamda Merzifon ilçesindeki kentsel su yönetimi su kaynakları, içme suyu iletim dağıtım şebekesi, su abone verileri, atık su sistemi, yağmursuyu sistemi incelenerek değerlendirilmiştir. İlçede içme suyu kaynaklarının oldukça kısıtlı olduğu, ancak içme suyu kapasitesinin artırılması ve şehir içi şebekesinin yenilenmesi ile ilgili olarak yapılan çalışmalarda sonuca ulaşılmasında zorluklar olduğu, buna karşılık su talebinin her geçen gün arttığı tespit edilmiştir. Kısa vadede gerekli önlemlerin alınmaması halinde ilçeyi büyük içme suyu sorununun beklediği ve bunun da sadece yerel yönetimin alacağı önlemlerle çözülemeyeceği dikkati çekmektedir. Orta ve büyük ölçekli şehirlerde su yönetimi sorunlarının çözümü için proje geliştirme, uygulama, şebeke yenileme, fiyatlama ve diğer işletme faaliyetlerinin yeniden gözden geçirilmesi ve iklim değişikliği riskleri de dikkate alınarak kentsel su yönetiminin yeniden düzenlenmesine gereksinim olduğu açıktır. Kentsel su arzı ve talebini teknik, mali, ekonomik, çevresel yönleri ile analiz edebilecek, havza ve alt havzalar düzeylerinde su yönetimi modellerinin geliştirilmesi, uygulanmasına olanak verebilecek tüzel kişiliğe haiz idari yapının oluşturulması gerekmektedir. Çok amaçlı kullanılan su kaynakları yönetiminin daha profesyonel bir yaklaşımla ele alınması zorunlu görülmektedir.
Nunca mais nesta vida
Authors: Hott Márden Cardoso Miranda
Published: December 2021

Não se aplica.
O Devir dos Animais Não-Humanos Em Um Mundo Pós-Pandêmico
Authors: Liebig Sueli Meira , Liebig Rafaela
Published: December 2021

O presente trabalho visa a trazer um olhar ecocrítico sobre os animais não-humanos a partir da consideração sobre o seu devir em um contexto pós-pandêmico, com enfoque antiespecista, posto que boa parte da literatura que retrata a relação entre seres humanos e demais espécies o faz sob uma perspectiva instrumental, considerando os interesses humanos e o valor do animal enquanto objeto, a exemplo da preservação dos animais silvestres enquanto elementos componentes da fauna. Aqui será apontado de que maneira as habilidades compartilhadas entre indivíduos humanos e não-humanos confluem para a caracterização dessa personalidade. Assim como o ideal de dignidade humana considerado está necessariamente atrelado ao conceito de mínimo existencial, com o consequente rol de direitos mínimos para sua autopreservação, em um devir pós-pandêmico -paralelamente e guardadas as devidas proporções - faz-se necessário a compreensão dos indivíduos não humanos enquanto – também- sujeitos de direito, com a construção de uma dignidade própria, derivada da dignidade humana, mas que com ela não se confunde
Análisis multimodal de cápsulas de salud: prevención selectiva del gobierno chileno en pandemia
Authors: Palacios Javiera
Published: December 2021

La presente investigación busca identificar los topoi argumentativos multimodales de 16 cápsulas audiovisuales de carácter informativo y preventivo emitidas por el Ministerio de Salud (MINSAL) del Gobierno de Chile de marzo a junio de 2020 en el marco de la pandemia mundial por COVID-19. Con tal propósito, se toma la base teórica de topoi (Wodak, 2003) como articulador argumentativo; los discursos de autoridad como generadores de representaciones mentales; y el rol multimodal para la emisión de mensajes de poder. Estos referentes conceptuales, junto a los postulados de los Estudios Críticos del Discurso (ECD), permiten identificar la función de los topoi y observar los mensajes multimodales dirigidos a la población, tomando como recursos centrales la visualidad (Abril, 2007), el tratamiento textual (Pardo, 2007) y sonoro (van Leeuwen, 1999). Los hallazgos indican que los topoi analizados muestran incongruencias discursivas en los diferentes recursos, donde, a pesar de emitir explícitamente informaciones preventivas, existen discursos implícitos que segmentan la imagen de “país ideal”. Bajo esa figura se manifiestan estereotipos que ocultan la diferencia, demostrando dialécticamente que los mensajes de cuidado de parte de la autoridad no velan por todos los chilenos.
“¡Hey! Un patacón ahí” Movilización de significados y construcción de identidades del barrio Getsemaní en Bizarre Foods
Authors: Morales Fonseca Julio
Published: December 2021

Este ensayo busca establecer el modo como el programa de TV estadounidense Bizarre Foods Americas construye identidades y significaciones acerca del barrio Getsemaní (Cartagena de Indias, Colombia) en la interacción entre un 'cocinero aventurero' de habla inglesa y la gente local del barrio, mediante recursos multimodales. Para la descripción e interpretación de los datos acudimos, por un lado, a la etnografía virtual (Domínguez, et.al., 2007; Pauwels, 2012) y, por otro, a conceptos relacionados con el lenguaje y la globalización para explicar la construcción de identidades (Blommaert, 2010; Pietikäinen, 2018; Menezes de Souza, 2019; Stroud, 2017). Los resultados muestran que a través de un diverso repertorio de recursos semióticos utilizados durante el programa, se establecen distintos elementos identitarios locales así como la perpetuación y legitimización de fenómenos sociales adversos para la población local referidos a relaciones sociales desiguales de poder y discursos colonialistas.