bluuebunny/crossref_metadata_2025 huggingface dataset:
Involvement levels of breast cancer patients—Seeking trusted hospital and physician
Authors: Boaz Hovav , Shuli Brammli-Greenberg
Published: December 2021

The active involvement levels of breast cancer patients (BCP) in treatment decisions range from 10% to 81%. We investigated the involvement levels of 179 Israeli breast cancer survivors, aged 30 to 81, in the choice of hospital, surgeon, surgical procedure, chemotherapy, and radiotherapy. High involvement was documented in location decisions (operating hospital 77%, chemotherapy facility 82%) as opposed to low involvement in treatment decisions (chemotherapy 30%–38%, radiotherapy 25%, surgical procedure 31%). Involvement was influenced by hospital and surgeon reputation, education level, and income. BCPs actively choose their treating facility and staff, and then follow their doctor’s recommendations.
Individual risky and protective factors influencing university new graduates’ career adaptability during COVID-19: A moderated mediation model
Authors: He Min , Yu Yongju
Published: December 2021

This study examined the characteristics of university new graduates’ career adaptability and the effects of individual internal factors during COVID-19. In January 2021, 1160 Chinese university new graduates completed self-report measures. Career adaptability was related to less intolerance of uncertainty and anxiety sensitivity and higher levels of proactive personality and resilience. Resilience mediated the relationships between intolerance of uncertainty, anxiety sensitivity, and career adaptability. Proactive personality buffered the negative effect of anxiety sensitivity on career adaptability. Implications for promoting career adaptability and alleviating the effects of intolerance of uncertainty and anxiety sensitivity in the COVID-19 epidemic and beyond are discussed.
Backdoor advertising scandals, Yingyeo culture, and cancel culture among YouTube Influencers in South Korea
Authors: Lee Jin , Abidin Crystal
Published: December 2021

In tandem with the increasing role of Influencers in culture and commerce, Influencers’ advertorial disclosures have become controversial in many countries, including South Korea. In August 2020, under the accusations by tabloids and other YouTubers, several famous Influencers were embroiled in the “backdoor advertising scandal,” wherein Influencers deftly advertise products in exchange for a significant amount of money from sponsoring companies, without any notice to followers. This article focuses on two (in)famous Influencers in the scandal: fashion stylist Han Haeyoun and mukbang-YouTuber tzuyang. By situating reactions around the scandal within broader Influencer ecologies and Korean cultures, we map out tensions between various actors, and the subsequent embroilments with online hate, call-out cultures, and misogyny. Drawing on a longitudinal digital ethnography on Influencer cultures and industry in East Asia, we highlight how the myth of “hitting the jackpot” in Korea compels people to follow, worship, and debunk Influencers within networked cultures.
Does Godwin’s law (rule of Nazi analogies) apply in observable reality? An empirical study of selected words in 199 million Reddit posts
Authors: Fariello Gabriele , Jemielniak Dariusz , Sulkowski Adam
Published: December 2021

As Godwin’s Law states, “as a discussion on the Internet grows longer, the likelihood of a person being compared to Hitler, or another Nazi reference, increases.” However, even though the theoretical probability of an infinitely long conversation including any term should approach 1.0, in practice, conversations cannot be infinite in length, and this long-accepted axiom is impossible to observe. By analyzing 199 million Reddit posts, we note that, after a certain point, the probability of observing the terms “Nazi” or “Hitler” actually decreases significantly with conversation length. In addition, a corollary of Godwin’s Law holds that “the invocation of Godwin’s Law is usually done by an individual that is losing the argument,” and, thus, that comparisons to Nazis are a signal of a discussion’s end. In other words, comparing one’s interlocutor to Hitler is supposed to be a conversation-killer. While it is difficult to determine whether a discussion on a given topic ended or not in a large dataset, we observe a marked increase in conversation length when the words “Hitler” or “Nazi” are newly interjected. Given that both of these observations challenge widely accepted and intuitive truisms, other words were run through the same set of tests. Within the context of the initial question, these results suggest that it is not inevitable that conversations eventually disintegrate into reductio ad Hitlerum, and that such comparisons are not conversation-killers. The results moreover suggest that we may underestimate, in the popular imagination, how much conversations may actually become narrower and therefore may tend to have a more impoverished or limited vocabulary as they stretch on. All of these observations provoke questions for further research.
Loading–unloading contact analysis of a fractal rough surface with functional gradation
Authors: Jana Tamonash , Mitra Anirban , Sahoo Prasanta
Published: December 2021

The present paper deals with a finite-element-based static loading–unloading analysis of a functionally graded rough surface contact with fractal characteristics. Two different gradation models, namely elastic and plastic gradations, are adopted. In these models, one out of yield strength and Young's modulus is varied spatially according to exponential functions, while the other is kept constant. In both these material models, separate inhomogeneity parameters control the variation of material properties. The gradation is such that throughout the top of the rough surface properties remain constant with variations in the depth direction being controlled by the above-mentioned parameters. Different fractal surfaces with different levels of roughness (governed by the values of fractal dimension and fractal roughness) have been analysed. The influence of the gradation parameters on the contact properties, viz. contact force, contact area, contact stress, etc., are investigated for both loading and unloading phases. It was found that for most of the loading phase, higher elastic, as well as plastic gradation parameter, causes higher contact force and contact area. However, in the case of the unloading of elastically graded surfaces, this trend is not maintained throughout. For the cases, where a substantial amount of yielding takes place during loading near the contact surface, the resulting contact area is found to be higher for the unloading phase in comparison with the same during the loading phase. The trend of plastic yielding at the vicinity of the contact surface is studied for varying gradation parameters. It is observed that the higher volume of yielded material is obtained for the higher value of elastic gradation parameter. On the other hand, the higher value of plastic gradation parameter causes more yielding to take place at the vicinity of the contact surface. Additionally, the effect of gradation on the energy dissipation due to plasticity after complete unloading is explored in detail.
Stress analysis of adhesively-bonded single stepped-lap joints based on three-parameter fractional viscoelastic foundation model
Authors: Veisytabar Mehdi , Reza Arash , Shekari Younes
Published: December 2021

This paper aims to develop a viscoelastic analytical model for adhesively bonded single stepped-lap joints subjected to tensile loading. The adherends are aluminum alloy A6063 and modeled as Timoshenko elastic beams and the adhesive is epoxy type B. A three-parameter fractional viscoelastic foundation (3PFVF) model is proposed to express the governing stresses in the joint and the fractional Zener model is used to model the viscoelastic behavior of the adhesive layer. The proposed 3PFVF model makes it possible to have different peel stresses between the two interfaces of adhesive and adherends. The governing differential equations are derived in the Laplace domain, and then solved and transformed simultaneously in the time domain using the Gaver-Stehfest inverse Laplace transform method. The finite element simulation with ANSYS is applied to validate the proposed method. The results show that a simple fractional viscoelastic model, which has a short differential equation, offers the same results as the classical viscoelastic models, which have higher and more complex differential equations. Moreover, the results show that the maximum shear and peel stresses in the single stepped-lap joints are about 20% less than single-lap joints.
Correlation of Neutrophil to Lymphocyte Ratio with Expression of Neutrophil Extracellular Traps Within Stroke Emboli
Authors: Larco Jorge Arturo , Abbasi Mehdi , Madhani Sarosh Irfan , Mereuta Madalina Oana , Liu Yang , Dai Daying , Kadirvel Ramanathan , Savastano Luis , Kallmes David F. , Brinjikji Waleed
Published: December 2021

Background & Purpose

It has been hypothesized that circulating neutrophils have a direct correlation with the composition of emboli in acute ischemic stroke (AIS). The aim of this study is to evaluate the association between neutrophil-lymphocyte ratio (NLR) in peripheral blood and the expression of neutrophil extracellular traps (NETs) within stroke emboli.

Methods

Consecutive patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO) that underwent mechanical thrombectomy (MT) were included. Patients were divided into two groups based on NLR median value. Retrieved thrombi were histologically analyzed using Martius Scarlett Blue (MSB) for main thrombus components including red blood cells (RBCs), white blood cells (WBCs), fibrin and platelet. Immunohistochemistry staining for von Willebrand Factor (vWF) and anti-citrullinated H3 (H3Cit; NETs marker) was also performed.

Results

Samples from a total of 84 patients were included. The average percentage of RBCs, WBCs, fibrin, platelet, H3Cit, and vWF components in thrombi were 45.1%, 3.5%, 21.8%, 29.6%, 19.7% and 14.8% respectively. When stratifying by NLR group [low (≤3.94) versus high (>3.95)], high NLR group had significantly more WBCs (4.5%), fibrin (24.2%), H3Cit (22.7%) and vWF (17.1%) thrombus fractions compared to low NLR group. Additionally, RBC content (38.8%) was lower in the high NLR group.

Conclusions

NLR is correlated with the amounts of WBCs, fibrin, NETs and vWF within the thrombi retrieved from AIS patients due to LVO.
A long-term survival rat model of spinal cord ischemia injury: Thoracic aortic occlusion combined with aortic bypass circulation
Authors: Yin Cheng-yong , Fei Jun-jie , Duan Yu-yin , Yang Ke , Li Xin , Wu Zhong-cheng , Huang Ying-Shan , Guo Yi
Published: December 2021

Objective

This study aims to investigate the methods for rat spinal cord ischemia injury models with a high long-term survival rate.

Methods

The rats were divided into three groups: the treatment group, the control group, and the sham operation group. The treatment group had a blocked thoracic aorta (landing zone 3 by Ishimaru – T11) + aortic bypass circulation for 20 min. In the control group, the thoracic aorta at the landing zone 3 was blocked for 20 min. In the sham operation group, only thoracotomy without thoracic aortic occlusion was performed. The mean arterial blood pressure (MABP) of the thoracic aorta and caudal artery before and after thoracic aortic occlusion was monitored intraoperatively. Spinal cord function was monitored by a transcranial motor evoked potential (Tc-MEP) during the operation. Spinal cord function was evaluated by the BBB scale (Basso, Beattie, & Bresnahan locomotor rating scale) scores at multiple postoperative time points. The spinal cord sections of the rats were observed for 7 days after surgery, and the survival curves were analyzed for 28 days after surgery.

Results

After aortic occlusion, the MABP of thoracic aorta decreased to 6% of that before occlusion, and the MABP of caudal artery decreased to 63% of that before occlusion in the treatment group. In the control group, the MABP of both thoracic aorta and caudal artery decreased to 19% of that before occlusion. The Tc-MEP waveform of the treatment group disappeared after 6 min, and that of the control group disappeared after 8 min until the end of surgery. There was no change in the Tc-MEP waveform in the sham operation group. The BBB score of the treatment group decreased more obviously than the control group, and there was a significant difference. There was no decrease in the sham group. Spinal cord sections showed a large number of degeneration and necrosis of neurons, infiltration of inflammatory cells, and proliferation of surrounding glial cells in the treatment group. In the control group, multiple neurons were necrotic. The histology of the sham operation group was normal. The 28-day survival rate of the treatment group was 73.3%, which was higher than the control group (40.0%), and there was a significant difference ( p < 0.05).

Conclusion

Thoracic aortic occlusion combined with aortic bypass is an effective modeling method for rats with accurate modeling effects and high long-term survival rates.
Factors associated with the elasticity of asymptomatic carotid plaques in hypertension Tibetan population
Authors: Liu Guyue , Xu Qing , Sun Min , Xiao Rong
Published: December 2021

Aims

Hypertension is a major risk factor for coronary, cerebrovascular, and the greatest cause of stroke. Half of stroke events are the result of cerebrovascular atherosclerosis, including carotid plaques. It is of major importance to detect which plaques are vulnerable, even though not yet ruptured. Due to the particularity of the Tibetan population, this study evaluated the elasticity of asymptomatic carotid plaques in Tibetan hypertension patients using shear wave elastography (SWE) and explored associated risk factors.

Methods

A total of 91 Tibetan patients were divided into normotension, grade 1-2, and grade 3 hypertension groups based on the level of blood pressure. All subjects underwent common duplex ultrasonic examination and SWE evaluation for carotid plaques. Elasticity of carotid plaque was assessed by Young’s modulus.

Results

The final analysis included 126 plaques as representative plaques according to Total Plaque Risk Score. The mean and maximum Young’s modulus in the grade 3 hypertension group were smaller, and more plaques with irregularity surface compared with the other two groups ( p < 0.05). Multivariate regression analysis showed drinking butter tea (β = −0.220, p = 0.009; β = −0.240, p = 0.004, respectively) was the independent factor associated with mean and maximum Young’s modulus.

Conclusions

SWE is feasible for measurement of Young’s modulus of carotid plaques. Plaques in the grade 3 hypertension group were more likely to become vulnerable ones. In hypertension Tibetan patients, drinking butter tea was an independent factor associated with mean and maximum Young’s modulus of asymptomatic carotid plaque.
Design of a novel clinical trial of prehospital pediatric airway management
Authors: Bosson Nichole , Hansen Matthew , Gausche-Hill Marianne , Lewis Roger J , Wendelberger Barbara , Shah Manish I , VanBuren John M , Wang Henry E
Published: December 2021

Emergency Medical Services personnel are often the first to intervene in the care of critically ill children. Airway management is a fundamental step in prehospital resuscitation, yet there is significant variation in current prehospital airway management practices. Our objective is to present a methodologic approach to determine the optimal strategy for prehospital pediatric airway management. We describe the conceptual premise for the Pediatric Prehospital Airway Resuscitation Trial, a novel Bayesian adaptive sequential platform trial. We developed an innovative design to enable comparison of the three predominant prehospital pediatric airway techniques (bag-mask-ventilation, supraglottic airway insertion, and endotracheal intubation) in three distinct disease groups (cardiac arrest, major trauma, and other respiratory failure). We used a Bayesian statistical approach to provide flexible modeling that can adapt based on prespecified rules according to accumulating trial data with patient enrollment continuing until stopping rules are met. The approach also allows the comparison of multiple interventions in sequence across the different disease states. This Bayesian hierarchical model will be the primary analysis method for the Pediatric Prehospital Airway Resuscitation Trial. The model integrates information across subgroups, a technique known as “borrowing” to generate accurate global and subgroup-specific estimates of treatment effects and enables comparisons of airway intervention arms within the overarching trial. We will use this Bayesian hierarchical linear model that adjusts for subgroup to estimate treatment effects within each subgroup. The model will predict a patient-centered score of 30-day intensive care unit-free survival using arm, subgroup, and emergency medical services agency as predictors. The novel approach of Pediatric Prehospital Airway Resuscitation Trial will provide a feasible method to determine the optimal strategy for prehospital pediatric airway management and may transform the design of future prehospital resuscitation trials.
Good Theories in Need of Better Data: Combining Clinical and Social Psychological Approaches to Study the Mechanisms Linking Relationships and Health
Authors: Farrell Allison K. , Stanton Sarah C. E. , Sbarra David A.
Published: December 2021

The study of intimate relationships and health is a fast-growing discipline with numerous well-developed theories, many of which outline specific interpersonal behaviors and psychological pathways that may give rise to good or poor health. In this article, we argue that the study of relationships and health can move toward interrogating these mechanisms with greater precision and detail, but doing so will require a shift in the nature of commonly used research methods in this area. Accordingly, we draw heavily on the science of behavior change and discuss six key methodologies that may galvanize the mechanistic study of relationships and health: dismantling studies, factorial studies, experimental therapeutics, experimental mediation research, multiple assessments, and recursive modeling. We provide empirical examples for each strategy and outline new ways in which a given approach may be used to study the mechanisms linking intimate relationships and health. We conclude by discussing the key challenges and limitations for using these research strategies as well as novel ideas about how to integrate this work into existing paradigms within the field.
The anatomy of the anconeus nerve redefined
Authors: Maniglio Mauro , Zaidenberg Ezequiel E. , Martinez Ezequiel F. , Zaidenberg Carlos R.
Published: December 2021

The anconeus nerve is the longest branch of the radial nerve and suitable as a donor for the neurotization of the axillary nerve. The aim of this study was to map its topographical course with reference to palpable, anatomical landmarks. The anconeus nerve was followed in 15 cadaveric specimens from its origin to its entry to the anconeus. It runs between the lateral and the medial head of the triceps before entering the medial head and running intramuscularly further distal. Exiting the muscle, it lies on the periosteum and the articular capsule of the elbow, before entering the anconeus muscle. Two types of anconeus nerve in relation to branches innervating triceps were found: nine nerves also innervated the lateral triceps head, while the other six only contributed two branches to its innervation. The course of the anconeus nerve is important for harvesting as a donor nerve and to protect the nerve in surgical elbow approaches.
The importance of embryology for parents of children with congenital hand differences
Authors: Clelland Andrew D. , Duncan Órla , Lam Wee L.
Published: December 2021

This study aimed to determine whether embryology knowledge or explaining the possible developmental pathway error was important for parents of affected children, and to secondarily determine if there was a relationship between desired knowledge of embryology and disease severity, maternal age group or maternal level of education. Using a self-administered questionnaire, a significant proportion of responding parents considered knowledge of embryology important (32 out of 43). We found a significant association between the importance of embryology knowledge for parents and the disease severity. However, the importance and level of knowledge desired was not related to maternal age or level of education. This study demonstrated the importance of explaining the associated developmental errors in the congenital hand consultation, particularly in severe anomalies. Surgeons should familiarize themselves with embryology to provide an explanation as to why congenital hand differences happen, which may provide better psychological support for parents of these children.
A study to compare strengths of cadaveric tendon repairs with round-bodied and cutting needles
Authors: Vissers Gino , Rusli Wan M. R. , Scarborough Alexander , Horwitz Maxim D. , McArthur Gordon J. , Kedgley Angela E.
Published: December 2021

This human cadaver study investigated whether flexor tendon repairs performed with round-bodied needles had a higher risk of pull-out compared with those performed with cutting needles. Forty human cadaver tendons were repaired (20 with each type of needle), subjected to tensile traction testing and evaluated by failure load and mode of failure. The average failure load was 50 N (SD 13 N) for tendons repaired with round-bodied needles, compared with 49 N (SD 16 N) for tendons repaired with cutting needles. Round-bodied needles resulted in more suture pull-out (18 out of 20 tendons) than cutting needles (6 out of 20 tendons). We found no differences in failure load, but significant differences in the mode of failure between round-bodied and cutting needles when used for cadaveric flexor tendon repair.
Metabolic syndrome is associated with prostate enlargement: a systematic review, meta-analysis, and meta-regression on patients with lower urinary tract symptom factors
Authors: Omran Asma , Leca Bianca M. , Oštarijaš Eduard , Graham Natasha , Da Silva Ana Sofia , Zaïr Zoulikha M. , Miras Alexander D. , le Roux Carel W. , Vincent Royce P. , Cardozo Linda , Dimitriadis Georgios K.
Published: December 2021

Background:

Metabolic syndrome (MetS) is defined by at least three of the following five criteria: blood pressure ⩾130/85 mmHg, fasting blood glucose ⩾5.6 mmol/l, triglycerides concentration ⩾1.7 mmol/l, waist circumference ⩾102 cm (for men), and high-density lipoprotein cholesterol concentration <1.03 mmol/l (for men). MetS has been associated with worse lower urinary tract symptoms (LUTS) and higher International Prostate Symptom questionnaire scores.

Materials and Methods:

MEDLINE, Cochrane, ClinicalTrials.gov, and SCOPUS were critically appraised for all peer-reviewed manuscripts that suitably fulfilled our protocol’s inclusion criteria established a priori. Meta-analytical and meta-regression calculations were performed in R using the Sidik–Jonkman and Hartung–Knapp random effects model and predefined covariates.

Results:

A total of 70 studies ( n = 90,206) were included in qualitative synthesis. From these, 60 studies focused on MetS and LUTS: 44 reported positive correlations, 5 reported negative correlations, 11 reported no association, and 10 studies focused on MetS and total prostate volume (TPV). MetS positively correlated with moderate LUTS [odds ratio (OR)  = 1.56, 95% confidence interval (CI) = 1.35–1.80], severe LUTS (OR = 2.35, 95% CI = 1.82–3.03), overactive bladder (OAB; OR = 3.2, 95% CI = 1.6–5.8), and nocturia severity (OR = 2.509, 95% CI = 1.571–4.007) at multivariate analysis. A total of 30 studies ( n = 22,206) were included in meta-analysis; MetS was significantly associated with higher TPV (mean differences = 4.4450 ml, 95% CI = 2.0177–6.8723), but no significant predictive factors for effect sizes were discovered.

Conclusion:

Our meta-analysis demonstrates a significant association between the aggravating effects of MetS, which commonly coexists with obesity and benign prostate enlargement.
Understanding and Translating Proverbs 25.27: Weighing the “Honorable” Options
Authors: Duke Rodney K.
Published: December 2021

Proverbs 25.27, particularly the second verset (27b) as found in the Masoretic Text, has created problems for interpreters. This paper identifies those problems and then lists, summarizes, and evaluates the major options that interpreters have offered as well as offering a couple of new options based on recognizing a double entendre.
The Newer Greek Text of the New Testament (NA28 and UBS5) and Its Implications for Translation
Authors: Scholz Vilson
Published: December 2021

Compared to the previous editions of the Greek New Testament, Nestle–Aland27 and UBS4, the newer editions (NA28 and UBS5) present some thirty-four changes, specifically in the Catholic Epistles. To what extent will this impact the translation of the New Testament? This paper will show that in half of those instances there will be some implication for translators and revisers of the New Testament.
Health chatbots acceptability moderated by perceived stigma and severity: A cross-sectional survey
Authors: Miles Oliver , West Robert , Nadarzynski Tom
Published: December 2021

Background

Chatbots and virtual voice assistants are increasingly common in primary care without sufficient evidence for their feasibility and effectiveness. We aimed to assess how perceived stigma and severity of various health issues are associated with the acceptability for three sources of health information and consultation: an automated chatbot, a General Practitioner (GP), or a combination of both.

Methods

Between May and June 2019, we conducted an online study, advertised via Facebook, for UK citizens. It was a factorial simulation experiment with three within-subject factors (perceived health issue stigma, severity, and consultation source) and six between-subject covariates. Acceptability rating for each consultation source was the dependant variable. A single mixed-model ANOVA was performed.

Results

Amongst 237 participants (65% aged over 45 years old, 73% women), GP consultations were seen as most acceptable, followed by GP-chatbot service. Chatbots were seen least acceptable as a consultation source for severe health issues, while the acceptability was significantly higher for stigmatised health issues. No associations between participants’ characteristics and acceptability were found.

Conclusions

Although healthcare professionals are perceived as the most desired sources of health information, chatbots may be useful for sensitive health issues in which disclosure of personal information is challenging. However, chatbots are less acceptable for health issues of higher severity and should not be recommended for use within that context. Policymakers and digital service designers need to recognise the limitations of health chatbots. Future research should establish a set of health topics most suitable for chatbot-led interventions and primary healthcare services.
Effect of Deficit Financing on Economic Growth in Bangladesh: Cointegration and VECM Approach
Authors: Alam Md Mahbub , Sadekin Md Nazmus , Islam Rabiul , Moudud-Ul-Huq Syed
Published: December 2021

Bangladesh has been encountering a budget deficit since 1972 because of a decrease in the source of income. This paper aims to examine the effect of budget deficit financing on economic growth in Bangladesh throughout 1981–2018. Using secondary data, the paper uses the cointegration test, vector error correction mechanism (VECM) and Granger causality test. Johansen’s cointegration test outcomes find that the study variables are cointegrated and subsequently have a long-run nexus among the variables. The study finds that in the long run, government domestic debt (GDD), government external debt (GEXD) and money supply (MS) affect positively economic growth (RGDP). The outcomes of the VECM approach express that in the short run, GDD, external debt and MS negatively affect economic growth. Also, short-run causality runs from the GDD, GEXD and MS to economic growth. The Granger causality test result shows unidirectional causal nexus running from GDD to RGDP, RGDP to external debt and GEXD to MS, and bidirectional causal nexus between MS and GDD in Bangladesh. The study suggests the governments should enhance moderate levels of domestic and external borrowing and uses it in productive and efficient ways to accelerate economic growth in Bangladesh.
Characterizing Head Impact Exposure in Men and Women During Boxing and Mixed Martial Arts
Authors: Jansen A. Elizabeth , McGrath Morgan , Samorezov Sergey , Johnston Joshua , Bartsch Adam , Alberts Jay
Published: December 2021

Background:

The accumulation of subconcussive impacts has been implicated in permanent neurological impairment. A gap in understanding the relationship between head impacts and neurological function is the lack of precise characterization and quantification of forces that individuals experience during sports training and competition.

Purpose:

To characterize impact exposure during training and competition among male and female athletes participating in boxing and mixed martial arts (MMA) via an instrumented custom-fit Impact Monitoring Mouthguard (IMM).

Study Design:

Cross-sectional study; Level of evidence, 3.

Methods:

Twenty-three athletes (n = 4 women) were provided a custom-fit IMM. The IMM monitored impacts during sparring and competition. All training and competition sessions were videotaped. Video and IMM data were synchronized for post hoc data verification of true positives and substantiation of impact location. IMM data were collected from boxing and MMA athletes at a collaborating site. For each true-positive impact, peak linear acceleration and peak angular acceleration were calculated. Wilcoxon rank sum tests were used to evaluate potential differences in sport, activity type, and sex with respect to each outcome. Differences in impact location were assessed via Kruskal-Wallis tests.

Results:

IMM data were collected from 53 amateur training sessions and 6 competitions (session range, 5-20 minutes). A total of 896 head impacts (men, n = 786; women, n = 110) were identified using IMM data and video verification: 827 in practice and 69 during competition. MMA and boxers experienced a comparable number of impacts per practice session or competition. In general, MMA impacts produced significantly higher peak angular acceleration than did boxing impacts ( P < .001) and were more varied in impact location on the head during competitions. In terms of sex, men experienced a greater number of impacts than women per practice session. However, there was no significant difference between men and women in terms of impact magnitude.

Conclusion:

Characteristic profiles of head impact exposure differed between boxing and MMA athletes; however, the impact magnitudes were not significantly different for male and female athletes.
Chaotic vibrations of carbon nanotubes subjected to a traversing force considering nonlocal elasticity theory
Authors: Ebrahimi Reza
Published: December 2021

The existence of chaos in the lateral vibration of the carbon nanotube (CNT) can contribute to source of instability and inaccuracy within the nano mechanical systems. So, chaotic vibrations of a simply supported CNT which is subjected to a traversing harmonic force are studied in this paper. The model of the system is formulated by using nonlocal Euler–Bernoulli beam theory. The equation of motion is solved using the Rung–Kutta method. The effects of the nonlocal parameter, velocity and amplitude of the traversing harmonic force on the nonlinear dynamic response of the system are analyzed by the bifurcation diagrams, phase plane portrait, power spectra analysis, Poincaré map and the maximum Lyapunov exponent. The results indicate that the nonlocal parameter, velocity and amplitude of the traversing harmonic force have considerable effects on the bifurcation behavior and can be used as effective control parameters for avoiding chaos.
On the taxonomy of smart city indicators and their alignment with sustainability and resilience
Authors: Sharifi Ayyoob , Allam Zaheer
Published: December 2021

As interest in smart city initiatives continues to grow rapidly, various involved actors and stakeholders increasingly rely on assessment frameworks or indicator sets for different purposes such as monitoring and benchmarking performance, identifying strengths and weaknesses, and determining priority intervention areas. Accordingly, many smart city assessment frameworks and/or indicator sets have been developed in the last decade. To guide actors and stakeholders in their selection of the most suitable frameworks, several studies have examined contents and structure of smart city assessment frameworks or indicator sets. Such studies have significantly improved our understanding of the thematic focus of assessment tools and their methodological approaches. However, there is still a lack of knowledge on the taxonomy of smart city indicators. In addition, since other concepts such as sustainability and resilience are increasingly recognized to be connected to the smart city concept, more clarity on how different assessment frameworks or indicator sets are aligned with sustainability and resilience dimensions and characteristics is needed. To fill these gaps, we developed a taxonomy and examined 33 assessment frameworks or indicator sets in terms of indicator type, sectoral linkages, and alignment with sustainability and resilience dimensions and characteristics. In terms of indicator type, results show that output indicators are dominant but limited attention has been paid to impact indicators. In terms of sectoral focus, existing indicators are mainly related to information and communication technologies, economy, and governance. Regarding resilience abilities, indicators are mainly related to planning abilities and limited attention has been paid to recovery and adaptation. As for resilience characteristics, reasonable levels of alignment with resourcefulness and efficiency were observed, but indicators are not well-aligned with other important characteristics such as redundancy and diversity. Finally, in terms of sustainability, limited alignment with the environmental dimension was found, which raises concerns regarding the suitability of smart city indicators for guiding environmental sustainability and informing efforts aimed at addressing climate change issues. Results of this study can support interested stakeholders in their efforts to select the most suitable assessment frameworks or indicator sets for promoting resilient, smart, and sustainable communities.
Optimal dimensionality selection for independent component analysis of transcriptomic data
Authors: McConn John Luke , Lamoureux Cameron R. , Poudel Saugat , Palsson Bernhard O. , Sastry Anand V.
Published: December 2021

Background

Independent component analysis is an unsupervised machine learning algorithm that separates a set of mixed signals into a set of statistically independent source signals. Applied to high-quality gene expression datasets, independent component analysis effectively reveals both the source signals of the transcriptome as co-regulated gene sets, and the activity levels of the underlying regulators across diverse experimental conditions. Two major variables that affect the final gene sets are the diversity of the expression profiles contained in the underlying data, and the user-defined number of independent components, or dimensionality, to compute. Availability of high-quality transcriptomic datasets has grown exponentially as high-throughput technologies have advanced; however, optimal dimensionality selection remains an open question.

Methods

We computed independent components across a range of dimensionalities for four gene expression datasets with varying dimensions (both in terms of number of genes and number of samples). We computed the correlation between independent components across different dimensionalities to understand how the overall structure evolves as the number of user-defined components increases. We then measured how well the resulting gene clusters reflected known regulatory mechanisms, and developed a set of metrics to assess the accuracy of the decomposition at a given dimension.

Results

We found that over-decomposition results in many independent components dominated by a single gene, whereas under-decomposition results in independent components that poorly capture the known regulatory structure. From these results, we developed a new method, called OptICA, for finding the optimal dimensionality that controls for both over- and under-decomposition. Specifically, OptICA selects the highest dimension that produces a low number of components that are dominated by a single gene. We show that OptICA outperforms two previously proposed methods for selecting the number of independent components across four transcriptomic databases of varying sizes.

Conclusions

OptICA avoids both over-decomposition and under-decomposition of transcriptomic datasets resulting in the best representation of the organism’s underlying transcriptional regulatory network.
The cold - resistance mechanism of a mutagenic Volvariella volvacea strain VH3 with outstanding traits revealed by transcriptome profiling
Authors: Li Peng , Hu Cong , Li Yujie , Ge Lei , Wu Guogan , Lv Beibei , Jiang Wei , Xi Dandan
Published: December 2021

Background

The straw mushroom (Volvariella volvacea) is one of the important vegetables that is popular for its delicious taste. However, the straw mushroom is sensitive to low temperature, resulting in economic loss during transportation and storage. We obtained a novel straw mushroom strain, named VH3, via ultraviolet mutagenesis.

Results

Our study revealed that VH3 exhibited high cold resistance compared to an ordinary straw mushroom cultivar, V23. We found that the electrolyte leakages of VH3 were always significantly lower than that of V23 treated with 4 °C for 0 h, 2 h,4 h, 8 h, 16 h, and 24 h. Before cold treatment (0 h), there were no difference of MDA contents, SOD activities, and CAT activities between VH3 and V23. At the late stage (8 h, 26 h, and 24 h) of cold treatment, the MDA contents of VH3 were lower while both the SOD and CAT activities were higher than those of V23. To investigate the potential mechanisms of VH3 cold resistance, we performed transcriptome sequencing to detect the transcriptome profiling of VH3 and V23 after 0 h and 4 h cold treatment. Transcriptome sequencing revealed that 111 differentially expressed genes (DEG) between V23 (0 h) and VH3 (0 h) (V23–0_vs_VH3–0), consisting 50 up-regulated and 61 down-regulated DEGs. A total of 117 DEGs were obtained between V23 (4 h) and VH3(4 h) (V23–4_vs_VH3–4), containing 94 up-regulated and 23 down-regulated DEGs. Among these DEGs, VVO_00021 and VVO_00017 were up-regulated while VVO_00003, VVO_00004, VVO_00010, and VVO_00030 were down-regulated in V23–0_vs_VH3–0 and VH3–4_vs_V23–4. KEGG and GO analysis revealed that the 6 DEGs were annotated to pathways related to cold stress. Besides, the GA3 content was also decreased in VH3.

Conclusions

Collectively, our study first revealed that the increased cold resistance of VH3 might be caused by the expression change of VVO_00003, VVO_00004, VVO_00017, VVO_00021, and VVO_00030, and decreased GA3.
Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson’s disease
Authors: Martínez-Horta Saul , Bejr-Kasem Helena , Horta-Barba Andrea , Pascual-Sedano Berta , Santos-García Diego , de Deus-Fonticoba Teresa , Jesús Silvia , Aguilar Miquel , Planellas Lluis , García-Caldentey Juan , Caballol Nuria , Vives-Pastor Bárbara , Hernández-Vara Jorge , Cabo-Lopez Iria , López-Manzanares Lydia , González-Aramburu Isabel , Ávila-Rivera Maria Asunción , Catalán Maria Jose , López-Díaz Luis Manuel , Puente Victor , García-Moreno Jose Manuel , Borrué Carmen , Solano-Vila Berta , Álvarez-Sauco Maria , Vela Lydia , Escalante Sonia , Cubo Esther , Carrillo-Padilla Francisco , Martínez-Castrillo Juan Carlos , Sánchez-Alonso Pilar , Alonso-Losada Maria Gema , López-Ariztegui Nuria , Gastón Itziar , Blázquez-Estrada Marta , Seijo-Martínez Manual , Rúiz-Martínez Javier , Valero-Merino Caridad , Kurtis Monica , de Fábregues-Boixar Oriol , González-Ardura Jessica , Prieto-Jurczynska Cristina , Martinez-Martin Pablo , Mir Pablo , Kulisevsky Jaime ,   COPPADIS Study Group
Published: December 2021

Background

Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson’s disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials.

Methods

Using a standard approach for the assessment of global cognition in PD and controlling for the effects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, metabolic variables and lifestyle variables in 533 PD participants from the COPPADIS study.

Results

Among the overall sample, 21% of participants were classified as PD-MCI (n = 114) and 4% as PDD (n = 26). The prevalence of hypertension, diabetes and dyslipidemia was significantly higher in cognitively impaired patients while no between-group differences were found for smoking, alcohol intake or use of supplementary vitamins. Better cognitive scores were significantly associated with regular physical exercise (p < 0.05) and cognitive stimulation (< 0.01). Cognitive performance was negatively associated with interleukin 2 (Il2) (p < 0.05), Il6 (p < 0.05), iron (p < 0.05), and homocysteine (p < 0.005) levels, and positively associated with vitamin B12 levels (p < 0.005).

Conclusions

We extend previous findings regarding the positive and negative influence of various comorbidities and lifestyle factors on cognitive status in early PD patients, and reinforce the need to identify and treat potentially modifiable variables with the intention of exploring the possible improvement of the global cognitive status of patients with PD.
Communicating with patients and families about illness progression and end of life: a review of studies using direct observation of clinical practice
Authors: Ekberg Stuart , Parry Ruth , Land Victoria , Ekberg Katie , Pino Marco , Antaki Charles , Jenkins Laura , Whittaker Becky
Published: December 2021

Background

There is growing recognition that a diverse range of healthcare professionals need competence in palliative approaches to care. Effective communication is a core component of such practice. This article informs evidence-based communication about illness progression and end of life through a rapid review of studies that directly observe how experienced clinicians manage such discussions.

Methods

The current rapid review updates findings of a 2014 systematic review, focussing more specifically on evidence related to illness progression and end-of-life conversations. Literature searches were conducted in nine bibliographic databases. Studies using conversation analysis or discourse analysis to examine recordings of actual conversations about illness progression or end of life were eligible for inclusion in the review. An aggregative approach was used to synthesise the findings of included studies.

Results

Following screening, 26 sources were deemed to meet eligibility criteria. Synthesis of study findings identified the structure and functioning of ten communication practices used in discussions about illness progression and end-of-life.

Conclusion

The ten practices identified underpin five evidence-based recommendations for communicating with patients or family members about illness progression and end of life.
How can we improve the experiences of patients and families who request medical assistance in dying? A multi-centre qualitative study
Authors: Oczkowski Simon J. W. , Crawshaw Diane E. , Austin Peggy , Versluis Donald , Kalles-Chan Gaelen , Kekewich Michael , Curran Dorothyann , Miller Paul , Kelly Michaela , Wiebe Ellen , Frolic Andrea
Published: December 2021

Background

Medical assistance in dying has been available in Canada for 5 years, but it is unclear which practices contribute to high-quality care. We aimed to describe patient and family perspectives of quality of care for medical assistance in dying.

Methods

We conducted a multi-centre, qualitative descriptive study, including face to face or virtual one-hour interviews using a semi-structured guide. We interviewed 21 english-speaking patients found eligible for medical assistance in dying and 17 family members at four sites in Canada, between November 2017 and September 2019. Interviews were de-identified, and analyzed in an iterative process of thematic analysis.

Results

We identified 18 themes. Sixteen themes were related to a single step in the process of medical assistance in dying (MAID requests, MAID assessments, preparation for dying, death and aftercare). Two themes (coordination and patient-centred care) were theme consistently across multiple steps in the MAID process. From these themes, alongside participant recommendations, we developed clinical practice suggestions which can guide care.

Conclusions

Patients and families identified process-specific successes and challenges during the process of medical assistance in dying. Most importantly, they identified the need for care coordination and a patient-centred approach as central to high-quality care. More research is required to characterize which aspects of care most influence patient and family satisfaction.
Anemia can predict the prognosis of colorectal cancer in the pre-operative stage: a retrospective analysis
Authors: Gvirtzman Rotem , Livovsky Dan Meir , Tahover Esther , Goldin Eran , Koslowsky Benjamin
Published: December 2021

Background

Early detection of colorectal cancer (CRC) improves prognosis, yet many CRCs are diagnosed following symptoms. The aim of this study was to determine which CRC-related symptoms or signs can predict an advanced CRC in the pre-operative stage.

Methods

Retrospective analysis of 300 patients who underwent surgery for CRC between the years 2008 and 2019. Patients’ symptoms prior to CRC diagnosis were documented. Primary endpoint was the association of signs or/and symptoms with CRC diagnosis at TNM stages of 2–4 (i.e., highly advanced), compared to TNM score of 0–1 (i.e., locally advanced).

Results

Three hundred patients, 91 with locally advanced and 209 with highly advanced CRC, were enrolled. There was a significant correlation between highly advanced CRC, compared to locally advanced, regarding tumor size (4.8 vs. 2.6 cm, p<0.001), presentation of any symptom prior to diagnosis (77% vs. 54%, p<0.001), anemia (46% vs. 29%, p=0.004), and severe anemia (17% vs. 4%, p=0.002). Mean hemoglobin was 12.2 ± 2.2 and 13.1 ± 1.8 in the highly advanced compared to locally advanced CRC, respectively, p<0.001. Anemia correlated with the T stage of the tumor: 21% of patients diagnosed at stages 0–1 had anemia, 39% at stage 2, 44% at stage 3, and 66% at stage 4 (p=0.001).

Conclusions

Anemia is the only finding that correlates with highly advanced CRC, in the pre-operative stage. When CRC has been diagnosed, the presence of anemia, at any level, may be considered in determining prognosis at the pre-operative stage. Physicians should be aware that when anemia is present, the risk for highly advanced CRC increases, and therefore should pursue with CRC detection.