bluuebunny/crossref_metadata_2025 huggingface dataset:
Video Searching and Fingerprint Detection by Using the Image Query and PlaceNet-Based Shot Boundary Detection Method
Authors: Jiang DaYou , Kim Jongweon
Published: September 2018

This work presents a novel shot boundary detection (SBD) method based on the Place-centric deep network (PlaceNet), with the aim of using video shots and image queries for video searching (VS) and fingerprint detection. The SBD method has three stages. In the first stage, we employed Local Binary Pattern-Singular Value Decomposition (LBP-SVD) features for candidate shot boundaries selection. In the second stage, we used the PlaceNet to select the shot boundary by semantic labels. In the third stage, we used the Scale-Invariant Feature Transform (SIFT) descriptor to eliminate falsely detected boundaries. The experimental results show that our SBD method is effective on a series of SBD datasets. In addition, video searching experiments are conducted by using one query image instead of video sequences. The results under several image transitions by using shot fingerprints have shown good precision.
Anticancer Activity of Cynomorium coccineum
Authors: Sdiri Mouna , Li Xiangmin , Du William , El-Bok Safia , Xie Yi-Zhen , Ben-Attia Mossadok , Yang Burton
Published: September 2018

The extensive applications of Cynomorium species and their rich bioactive secondary metabolites have inspired many pharmacological investigations. Previous research has been conducted to examine the biological activities and numerous interesting pharmaceutical activities have been reported. However, the antitumor activities of these species are unclear. To understand the potential anticancer activity, we screened Cynomorium coccineum and Cynomorium songaricum using three different extracts of each species. In this study, the selected extracts were evaluated for their ability to decrease survival rates of five different cancer cell lines. We compared the cytotoxicity of the three different extracts to the anticancer drug vinblastine and one of the most well-known medicinal mushrooms Amaurederma rude. We found that the water and alcohol extracts of C. coccineum at the very low concentrations possessed very high capacity in decreasing the cancer cells viability with a potential inhibition of tumorigenesis. Based on these primitive data, we subsequently tested the ethanol and the water extracts of C. coccineum, respectively in in vitro and in vivo assays. Cell cycle progression and induction of programmed cell death were investigated at both biological and molecular levels to understand the mechanism of the antitumor inhibitory action of the C. coccineum. The in vitro experiments showed that the treated cancer cells formed fewer and smaller colonies than the untreated cells. Cell cycle progression was inhibited, and the ethanol extract of C. coccineum at a low concentration induced accumulation of cells in the G1 phase. We also found that the C. coccineum’s extracts suppressed viability of two murine cancer cell lines. In the in vivo experiments, we injected mice with murine cancer cell line B16, followed by peritoneal injection of the water extract. The treatment prolonged mouse survival significantly. The tumors grew at a slower rate than the control. Down-regulation of c-myc expression appeared to be associated with these effects. Further investigation showed that treatment with C. coccineum induced the overexpression of the tumor suppressor Foxo3 and other molecules involved in inducing autophagy. These results showed that the C. coccineum extract exerts its antiproliferative activity through the induction of cell death pathway. Thus, the Cynomorium plants appear to be a promising source of new antineoplastic compounds.
A Novel Role for the Interleukin-1 Receptor Axis in Resistance to Anti-EGFR Therapy
Authors: Gelfo Valerio , Mazzeschi Martina , Grilli Giada , Lindzen Moshit , Santi Spartaco , D’Uva Gabriele , Győrffy Balázs , Ardizzoni Andrea , Yarden Yosef , Lauriola Mattia
Published: September 2018

Cetuximab (CTX) is a monoclonal antibody targeting the epidermal growth factor receptor (EGFR), commonly used to treat patients with metastatic colorectal cancer (mCRC). Unfortunately, objective remissions occur only in a minority of patients and are of short duration, with a population of cells surviving the treatment and eventually enabling CTX resistance. Our previous study on CRC xenopatients associated poor response to CTX with increased abundance of a set of pro-inflammatory cytokines, including the interleukins IL-1A, IL-1B and IL-8. Stemming from these observations, our current work aimed to assess the role of IL-1 pathway activity in CTX resistance. We employed a recombinant decoy TRAP IL-1, a soluble protein combining the human immunoglobulin Fc portion linked to the extracellular region of the IL-1-receptor (IL-1R1), able to sequester IL-1 directly from the medium. We generated stable clones expressing and secreting a functional TRAP IL-1 into the culture medium. Our results show that IL-1R1 inhibition leads to a decreased cell proliferation and a dampened MAPK and AKT axes. Moreover, CRC patients not responding to CTX blockage displayed higher levels of IL-1R1 than responsive subjects, and abundant IL-1R1 is predictive of survival in patient datasets specifically for the consensus molecular subtype 1 (CMS1). We conclude that IL-1R1 abundance may represent a therapeutic marker for patients who become refractory to monoclonal antibody therapy, while inhibition of IL-1R1 by TRAP IL-1 may offer a novel therapeutic strategy.
Titanate Nanotube-Supported Au–Rh Bimetallic Catalysts: Characterization and Their Catalytic Performances in Hydroformylation of Vinyl Acetate
Authors: Chen Ya , Su Penghe , Liu Xiaotong , Liu Hongchi , Zhu Baolin , Zhang Shoumin , Huang Weiping
Published: September 2018

A series of titanate nanotube-supported metal catalysts (M/TNTs, M = Rh, Au orAu–Rh) were facilely synthesized. The effects of different Au contents, reduction processes and sequence of loading metals on their catalytic performances in the hydroformylation of vinyl acetate were comparatively investigated. The results showed that some Au and Rh formed bimetallic particles. Furthermore, the presence of Au in catalysts could significantly improve the selectivity of reaction for aldehydes. Compared with the monometallic catalysts (Rh0.33/TNTs-1 and Au0.49/TNTs-2), the resultant bimetallic catalysts exhibited significantly higher selectivity for aldehydes as well as higher TOF values in the hydroformylation of vinyl acetate. Among them, Au0.52/Rh0.32/TNTs-12 displayed the best catalytic performance. The corresponding selectivity for aldehydes was as high as 88.67%and the turnover frequency (TOF) reached up to 3500 h−1. In addition, for the reduction of Rh3+ and Au3+ ions, the photo-reduction and ethanol-reduction were the optimal techniques under the present conditions, respectively.
Epigenetic Study in Parkinson’s Disease: A Pilot Analysis of DNA Methylation in Candidate Genes in Brain
Authors: Navarro-Sánchez Luis , Águeda-Gómez Beatriz , Aparicio Silvia , Pérez-Tur Jordi
Published: September 2018

Efforts have been made to understand the pathophysiology of Parkinson’s disease (PD). A significant number of studies have focused on genetics, despite the fact that the described pathogenic mutations have been observed only in around 10% of patients; this observation supports the fact that PD is a multifactorial disorder. Lately, differences in miRNA expression, histone modification, and DNA methylation levels have been described, highlighting the importance of epigenetic factors in PD etiology. Taking all this into consideration, we hypothesized that an alteration in the level of methylation in PD-related genes could be related to disease pathogenesis, possibly due to alterations in gene expression. After analysing promoter regions of five PD-related genes in three brain regions by pyrosequencing, we observed some differences in DNA methylation levels (hypo and hypermethylation) in substantia nigra in some CpG dinucleotides that, possibly through an alteration in Sp1 binding, could alter their expression.
Wrist-Based Accelerometer Cut-Points to Identify Sedentary Time in 5–11-Year-Old Children
Authors: Chandler Jessica , Beets Michael , Saint-Maurice Pedro , Weaver Robert , Cliff Dylan , Drenowatz Clemens , Moore Justin , Sui Xuemei , Brazendale Keith
Published: September 2018

Background: The objective of this paper is to derive a wrist-placed cut-point threshold for distinguishing sedentary behaviors from light-intensity walking using the ActiGraph GT3X+ in children. Methods: This study employed a cross-sectional study design, typically used in measurement-related studies. A sample of 167 children, ages 5–11 years (mean ± SD: 8.0 ± 1.8 years), performed up to eight seated sedentary activities while wearing accelerometers on both wrists. Activities included: reading books, sorting cards, cutting and pasting, playing board games, eating snacks, playing with tablets, watching TV, and writing. Direct observation verified sedentary behavior from light activity. Receiver operator characteristic (ROC) analyses were used to determine optimal cut-point thresholds. Quantile regression models estimated differences between dominant and non-dominant placement. Results: The optimal cut-point threshold for the non-dominant wrist was 203 counts/5 s with sensitivity, specificity, and area under the curve (AUC) of 71.56, 70.83, and 0.72, respectively. A 10-fold cross-validation revealed an average AUC of 0.70. Statistically significant (p ≤ 0.05) differences in median counts ranging from 7 to 46 counts/5 s were found between dominant and non-dominant placement in five out of eight sedentary activities, with the dominant wrist eliciting higher counts/5 s. Conclusion: Results from this study support the recommendation to place accelerometers on the non-dominant wrist to minimize “noise” during seated sedentary behaviors.
Exploring Gender Differences within Forest Schools as a Physical Activity Intervention
Authors: Trapasso Emilia , Knowles Zoe , Boddy Lynne , Newson Lisa , Sayers Jo , Austin Clare
Published: September 2018

This study investigated whether children engaged in more physical activity (PA) on school days that included Forest School (FS) sessions than a regular school day or a school day with a Physical Education (PE) lesson. How FS sessions influenced children’s general levels of PA and wellbeing was also explored across gender. A mixed-methods study followed a sample of 59 child participants aged 7 to 9 years old, from four primary schools, whilst taking part in twelve weekly FS sessions. Measures included the PA Questionnaire for Older Children and accelerometry data together with an individual Write and Draw task to inform focus groups. Children had significantly greater levels of light PA on a FS day and a PE school day compared to a regular school day and children reported feeling both happier and relaxed as a consequence of the intervention. From the qualitative data, boys and girls reported different likes of the FS interventions, whereas their dislikes of FS were comparable. Findings from this research provide evidence for such outdoor, nature-based learning within the school curriculum contributing to daily PA in children.
A Proposal to Evaluate Drought Characteristics Using Multiple Climate Models for Multiple Timescales
Authors: Tien Thanh Nguyen
Published: September 2018

This study presents a method to investigate meteorological drought characteristics using multiple climate models for multiple timescales under two representative concentration pathway (RCP) scenarios, RCP4.5 and RCP8.5, during 2021–2050. The methods of delta change factor, unequal weights, standardized precipitation index, Mann–Kendall and Sen’s slope are proposed and applied with the main purpose of reducing uncertainty in climate projections and detection of the projection trends in meteorological drought. Climate simulations of three regional climate models driven by four global climate models are used to estimate weights for each run on the basic of rank sum. The reliability is then assessed by comparing a weighted ensemble climate output with observations during 1989–2008. Timescales of 1, 3, 6, 9, 12, and 24 months are considered to calculate the standardized precipitation index, taking the Vu Gia-Thu Bon (VG-TB) as a pilot basin. The results show efficient precipitation simulations using unequal weights. In the same timescales, the occurrence of moderately wet events is smaller than that of moderately dry events under the RCP4.5 scenario during 2021–2050. Events classified as “extremely wet”, “extremely dry”, “very wet” and “severely dry” are expected to rarely occur under the RCP8.5 scenario.
Coarse Graining, Nonmaximal Entropy, and Power Laws
Authors: Pérez-Cárdenas Fernando C. , Resca Lorenzo , Pegg Ian L.
Published: September 2018

We show that coarse graining produces significant and predictable effects on the entropy of states of equilibrium when the scale of coarse graining becomes comparable to that of density fluctuations. We demonstrate that a coarse-grained entropy typically evolves toward a state of effective equilibrium with a lower value than that of the state of maximum entropy theoretically possible. The finer the coarse graining, the greater the drop in effective entropy, and the more relevant the fluctuations around that. Fundamental considerations allow us to derive a remarkable power law that relates coarse graining to the effective entropy gap. Another power law is found that precisely relates the noise range of effective entropy fluctuations to coarse graining. We test both power laws with numerical simulations based on a well-studied two-dimensional lattice gas model. As expected, the effects of these power laws diminish as our description approaches a macroscopic level, eventually disappearing in the thermodynamic limit, where the maximum entropy principle is reasserted.
Real-World Measurement of Hybrid Buses’ Fuel Consumption and Pollutant Emissions in a Metropolitan Urban Road Network
Authors: Keramydas Christos , Papadopoulos Georgios , Ntziachristos Leonidas , Lo Ting-Shek , Ng Kwok-Lam , Wong Hok-Lai , Wong Carol
Published: September 2018

This study investigates pollutant emissions and fuel consumption of six Euro VI hybrid-diesel public transport buses operating on different scheduled routes in a metropolitan urban road network. Portable emission measurement systems (PEMS) are used in measurements and results are compared to those obtained from a paired number of Euro V conventional buses of the same body type used as control over the same routes. The selected routes vary from urban to highway driving and the experimentation was conducted over the first half of 2015. The available emissions data correspond to a wide range of driving, operating, and ambient conditions. Fuel consumption, distance- and energy-based emission levels are derived and presented in a comparative manner. The effect of different factors, including speed, ambient temperature, and road grade on fuel consumption and emissions performance is investigated. Mean fuel consumption of hybrid buses was found 6.1% lower than conventional ones, from 20% lower up to 16% higher, over six routes tested in total. The mean route difference between the two technologies was not statistically significant. Air conditioning decreased consumption benefits of the hybrid buses. Decrease of the mean route speed from 15 km h−1 tο 8 km h−1 increased the hybrid buses consumption by 63%. Nitrogen oxides (NOx) emissions of the Euro VI hybrid buses were 93 ± 5% lower than conventional Euro V ones. Nitrous oxide (N2O) emissions from hybrid Euro VI buses made up 5.9% of total greenhouse gas emissions and largely offset carbon dioxide (CO2) benefits. The results suggest that hybrid urban buses need to be assessed under realistic operation and environmental conditions to assess their true environmental and fuel consumption benefits.
The Impact of Effective Microorganisms (EM) and Organic and Mineral Fertilizers on the Growth and Mycorrhizal Colonization of Fagus sylvatica and Quercus robur Seedlings in a Bare-Root Nursery Experiment
Authors: Bzdyk Roman Mariusz , Olchowik Jacek , Studnicki Marcin , Oszako Tomasz , Sikora Katarzyna , Szmidla Hanna , Hilszczańska Dorota
Published: September 2018

Every year there are changes in the register of fungicides available for forestry. It is proactive to develop a new strategy to minimise the application of chemical methods and replace them with natural and biological fungal control options. This study compares the influence after one growing season in a bare-root forest nursery of (a) effective microorganisms (EM) consisting of mixed cultures of beneficial and naturally-occurring microorganisms, (b) the organic fertilizer Actifos (Act), and (c) the mineral fertilizer Busz Forte (BF) on the growth and mycorrhizal colonization of two common forest deciduous tree species: Fagus sylvatica and Quercus robur. None of the analysed growth parameters (root collar diameter, length of shoots and roots, dry mass of shoots, and roots) of either tested tree species differed significantly among treatments. For both tree species, seedlings treated with EM exhibited partnerships with a smaller species richness of mycorrhizae than did seedlings in other treatments. Moreover, EM treatment significantly increased the abundance of non-vital root tips for both species. By contrast, BF exerted a negative effect on F. sylvatica non-vital mycorrhiza abundance. Based on morphological and molecular identification, a total of 11 ectomycorrhizal (ECM) fungal taxa were detected in this study; three species (Peziza ostracoderma, Scleroderma areolatum and Cenococcum-like) were shared between both plant species. Across treatments, the most abundant ECM fungal species on F. sylvatica roots were Pezizaceae sp. (51.1%) and Hebeloma sp. (38.1%), while Peziza ostracoderma (26.8%), Naucoria salicis (24.1%), and Scleroderma areolatum (16.9%) were the most abundant taxa on Q. robur seedling roots. Our data indicate a negative effect of EM on ectomycorrhizal colonisation and on species richness of ECM fungi associated with F. sylvatica and Q. robur seedlings. None of the tested products had a negative effect on seedling growth, but seedlings treated with EM were characterised by a significant higher abundance of non-vital mycorrhizae.
Power Laws in Fractionally Electronic Elements
Authors: Li Ming
Published: September 2018

The highlight presented in this short article is about the power laws with respect to fractional capacitance and fractional inductance in terms of frequency.
The Remains of Arnau de Torroja, 9th Grand Master of the Knights Templar, Discovered in Verona
Authors: Galobart Leticia Darna
Published: September 2018

The members of the Torroja family were extremely important as advisers on political and military strategy to the counts of Barcelona (monarchs of the Crown of Aragon) Arnaldo was elected Grand Master of the Knights Templar (1181–1184). On 30 September 1184, the Templar Master passed away in the city of Veneto; Arnaldo de Torroja was buried at the church of San Vitale in Verona. The church was destroyed when the river Adige flooded it in the 18th century, and it was closed down in 1760 as a result of the damage caused. Some years ago, behind a wall, a sarcophagus was discovered on which was carved the typical Templar cross (Cross patty) and, in 2016, it was opened by a team of Italian scientists. The skeletal remains corresponded to the age Arnaldo. Thanks to the book that I recently published “Armorial de los Obispos de Barcelona, siglos XII–XXI”, it has been realized that the sarcophagus of the brother of Arnaldo of Torroja, Guillermo is contained within the Family heraldry “Golden a castle of Gules”, they requested that the aforementioned bishop’s remains be analysed, in order to compare them with those of Arnaldo.
Synchrotron-Based Micro-CT Investigation of Oxic Corrosion of Copper-Coated Carbon Steel for Potential Use in a Deep Geological Repository for Used Nuclear Fuel
Authors: Standish Thalia E. , Zagidulin Dmitrij , Ramamurthy Sridhar , Keech Peter G. , Shoesmith David W. , Noël James J.
Published: September 2018

Within the multi-barrier system proposed for the permanent disposal of used nuclear fuel, the primary engineered barrier is the sealed metallic container. The present Canadian container design utilizes a carbon steel vessel coated with Cu for corrosion protection. In the event of a defect in the Cu coating that exposes the steel substrate, galvanically accelerated corrosion of steel is, in principle, possible. In this work, the progression of corrosion at a simulated through-coating defect in 3.0 mol/L NaCl solution containing dissolved O2 was monitored using electrochemical measurements and imaged non-destructively using synchrotron X-ray micro computed tomography (micro-CT). The damage volume at the base of the simulated defect was measured from the 3D micro-CT data and used to calculate the amount of O2 used to drive steel corrosion. The results demonstrate that the availability of O2 determines the rate and overall extent of corrosion, while the coatings produced using different deposition and treatment methods (cold spray deposition, heat-treated cold spray deposition, electrodeposition) lead to different corrosion propagation geometries, with the distribution of damage depending on the quality of the Cu/steel interface.
Implementing Chief Resident Immersion Training (CRIT) in the Care of Older Adults: Overcoming Barriers and Promoting Facilitators
Authors: Furman Christian Davis , Wagner Lori , Gomes Josephine , Gopalraj Rangaraj , Parker B. Frank , Morton Laura , Antimisiaris Demetra , Neamtu Daniela , Masroor Sadaf , Martin-Galijatovic Ramie , Cotton Samantha , Shaw M. Ann
Published: September 2018

The Chief Resident Immersion Training (CRIT) in the Care of Older Adults curriculum was developed at Boston University School of Medicine to improve the care of older adults through an educational intervention. The curriculum targeted chief residents (CRs) because their role as mediators between learners and faculty provides the greatest potential impact for transmitting knowledge. The goals of CRIT are to: (1) provide education on geriatric principles and on teaching/leadership skills, (2) foster interdisciplinary collaboration, and (3) complete an action project. This study demonstrates successful implementation of CRIT at a different academic institution in a rural state. The CRs indicated that their confidence in their ability to apply and teach geriatrics improved after CRIT. In addition, the CRs indicated that CRIT improved their confidence in their overall skills as CRs. The barriers and facilitators to implementation are addressed in order to promote successful adoption of CRIT at other institutions, including those in rural states.
Health Risk Perceptions Are Associated with Domestic Use of Basic Water and Sanitation Services—Evidence from Rural Ethiopia
Authors: Anthonj Carmen , Fleming Lisa , Godfrey Samuel , Ambelu Argaw , Bevan Jane , Cronk Ryan , Bartram Jamie
Published: September 2018

We examine factors associated with the use of basic water supply and sanitation services as part of an integrated community-based nutrition programme which included a drinking water, sanitation and hygiene (WaSH) intervention and emphasise findings related to health risk perceptions. Data were collected from 2658 households in four regions in Ethiopia with a cross-sectional survey in WaSH intervention areas, as well as in control areas, where the intervention was not implemented. The data were analysed using bivariate and multivariable regression analysis. Awareness of health risk factors related to inadequate WaSH was high in the programme area. The use of basic water and sanitation services was associated with several health risk perceptions: Perceiving water quality as good increased the odds of using basic water services as opposed to believing the water quality was poor (OR 3.94; CI 3.06–5.08; p ≤ 0.001). Believing that drinking unsafe water was the main cause for diarrhoea increased the odds of using basic water services (OR 1.48; CI 1.20–1.81; p ≤ 0.001). In the WaSH intervention group, the use of basic sanitation was more likely than in the control group. The use of basic sanitation was associated with households who had previously received sanitation training, as opposed to such who had not (OR 1.55; CI 1.22–1.97; p ≤ 0.001). Perceiving dirty space as the main cause of diarrhoea (OR 1.81; CI 1.50–2.19; p ≤ 0.001), and privacy when using a latrine (OR 2.00; CI 1.67–2.40; p ≤ 0.001), were associated with higher odds of using basic sanitation. Households that indicated a disadvantage of owning a latrine was maintenance costs were less likely to use basic sanitation (OR 0.49; CI 0.38–0.63; p ≤ 0.001). Risk perceptions were important determinants of use of basic services. The findings point to risk perceptions motivating the application of positive WaSH-related and health-protective behaviours. This suggests that well-designed health risk communication strategies may be effective for engaging households in healthy WaSH behaviour.
Spatiotemporal Variability of Soil Nitrogen in Relation to Environmental Factors in a Low Hilly Region of Southeastern China
Authors: He Shan , Zhu Hailun , Shahtahmassebi Amir Reza , Qiu Lefeng , Wu Chaofan , Shen Zhangquan , Wang Ke
Published: September 2018

Soil total nitrogen (TN) plays a major role in agriculture, geochemical cycles and terrestrial ecosystem functions. Knowledge regarding the TN distribution is crucial for the sustainable use of soil resources. This paper therefore aims to characterize the spatiotemporal distribution of soil TN and improve the current understanding of how various factors influence changes in TN. Natural characteristics and remote sensing (RS) variables were used in conjunction with the random forest (RF) model to map the TN distribution in a low hilly region of southeastern China in 1979, 2004 and 2014. The means and changes of TN in different geographic regions and farmland protection regions were also analyzed. The results showed that: (1) the TN showed an increasing trend in the early periods and exhibited a decreasing trend from 2004 to 2014; (2) the geographic and RS variables played more important roles in predicting TN distribution than did the other variables; and (3) changes in the fertilization and crop planting structure caused by soil testing and formulated fertilization techniques (STFFT—Soil Testing and Formulated Fertilization Techniques) as well as farmland protection policies influenced the spatiotemporal variability of TN. Evidently, more attention should be focused on improving the quality and soil fertility in the surrounding low mountainous areas.
Addressing Suicide Risk According to Different Healthcare Professionals in Spain: A Qualitative Study
Authors: Muñoz-Sánchez Juan-Luis , Sánchez-Gómez María Cruz , Martín-Cilleros María Victoria , Parra-Vidales Esther , De Leo Diego , Franco-Martín Manuel A.
Published: September 2018

This study analyzes the views of four groups of healthcare professionals who may play a role in the management of suicidal behavior. The goal was to identify key factors for suicide prevention in different areas of the healthcare system. Qualitative research was conducted using focus groups made up of different healthcare professionals who participated in the identification, management, and prevention of suicidal behavior. Professionals included were primary care physicians, psychologists, psychiatrists, and emergency physicians. ‘Suicide’ was amongst the most relevant terms that came up in discussions most of the times it appeared associated with words such as ‘risk’, danger’, or ‘harm’. In the analysis by categories, the four groups of professionals agreed that interventions in at-risk behaviors are first in importance. Prevention was the second main concern with greater significance among psychiatrists. Primary care professionals call for more time to address patients at risk for suicide and easier access to and communication with the mental health network. Emergency care professionals have a lack of awareness of their role in the detection of risk for suicide in patients who seek attention at emergency care facilities for reasons of general somatic issues. Mental health care professionals are in high demand in cases of self-harm, but they would like to receive specific training in dealing with suicidal behavior.
Multi-Temporal Sentinel-1 and -2 Data Fusion for Optical Image Simulation
Authors: He Wei , Yokoya Naoto
Published: September 2018

In this paper, we present the optical image simulation from synthetic aperture radar (SAR) data using deep learning based methods. Two models, i.e., optical image simulation directly from the SAR data and from multi-temporal SAR-optical data, are proposed to testify the possibilities. The deep learning based methods that we chose to achieve the models are a convolutional neural network (CNN) with a residual architecture and a conditional generative adversarial network (cGAN). We validate our models using the Sentinel-1 and -2 datasets. The experiments demonstrate that the model with multi-temporal SAR-optical data can successfully simulate the optical image; meanwhile, the state-of-the-art model with simple SAR data as input failed. The optical image simulation results indicate the possibility of SAR-optical information blending for the subsequent applications such as large-scale cloud removal, and optical data temporal super-resolution. We also investigate the sensitivity of the proposed models against the training samples, and reveal possible future directions.
The Effects of Land Use and Land Cover Geoinformation Raster Generalization in the Analysis of LUCC in Portugal
Authors: Meneses Bruno M. , Reis Eusébio , Reis Rui , Vale Maria J.
Published: September 2018

Multiple land use and land cover (LUC) datasets are available for the analysis of LUC changes (LUCC) in distinct territories. Sometimes, different LUCC results are produced to characterize these changes for the same territory and the same period. These differences reflect: (1) The different properties of LUC geoinformation (GI) used in the LUCC assessment, and (2) different criteria used for vector-to-raster conversion, namely, those deriving from outputs with different spatial resolutions. In this research, we analyze LUCC in mainland Portugal using two LUC datasets with different properties: Corine Land Cover (CLC 2006 and 2012) and LUC official maps of Portugal (Carta de Ocupação do Solo, COS 2007 and 2010) provided by the European Environment Agency (EEA) and the General Directorate for Territorial Development (DGT). Each LUC dataset has undergone vector-to-raster conversion, with different resolutions (10, 25, 50, 100, and 200 m). LUCC were analyzed based on the vector GI of each LUC dataset, and with LUC raster outputs using different resolutions. Initially, it was observed that the areas with different LUC types in two LUC datasets in vector format were not similar—a fact explained by the different properties of this type of GI. When using raster GI to perform the analysis of LUCC, it was observed that at high resolutions, the results are identical to the results obtained when using vector GI, but this ratio decreases with increased cell size. In the analysis of LUCC results obtained with raster LUC GI, the outputs with pixel size greater than 100 m do not follow the same trend of LUCC obtained with high raster resolutions or using LUCC obtained with vector GI. These results point out the importance of the factor form and the area of the polygons, and different effects of amalgamation and dilation in the vector-to-raster conversion process, more evident at low resolutions. These findings are important for future evaluations of LUCC that integrate raster GI and vector/raster conversions, because the different LUC GI resolution in line with accuracy can explain the different results obtained in the evaluation of LUCC. The present work demonstrates this fact, i.e., the effects of vector-to-raster conversions using various resolutions culminated in different results of LUCC.
Liposomal Formulations to Modulate the Tumour Microenvironment and Antitumour Immune Response
Authors: Gilabert-Oriol Roger , Ryan Gemma M. , Leung Ada W.Y. , Firmino Natalie S. , Bennewith Kevin L. , Bally Marcel B.
Published: September 2018

Tumours are complex systems of genetically diverse malignant cells that proliferate in the presence of a heterogeneous microenvironment consisting of host derived microvasculature, stromal, and immune cells. The components of the tumour microenvironment (TME) communicate with each other and with cancer cells, to regulate cellular processes that can inhibit, as well as enhance, tumour growth. Therapeutic strategies have been developed to modulate the TME and cancer-associated immune response. However, modulating compounds are often insoluble (aqueous solubility of less than 1 mg/mL) and have suboptimal pharmacokinetics that prevent therapeutically relevant drug concentrations from reaching the appropriate sites within the tumour. Nanomedicines and, in particular, liposomal formulations of relevant drug candidates, define clinically meaningful drug delivery systems that have the potential to ensure that the right drug candidate is delivered to the right area within tumours at the right time. Following encapsulation in liposomes, drug candidates often display extended plasma half-lives, higher plasma concentrations and may accumulate directly in the tumour tissue. Liposomes can normalise the tumour blood vessel structure and enhance the immunogenicity of tumour cell death; relatively unrecognised impacts associated with using liposomal formulations. This review describes liposomal formulations that affect components of the TME. A focus is placed on formulations which are approved for use in the clinic. The concept of tumour immunogenicity, and how liposomes may enhance radiation and chemotherapy-induced immunogenic cell death (ICD), is discussed. Liposomes are currently an indispensable tool in the treatment of cancer, and their contribution to cancer therapy may gain even further importance by incorporating modulators of the TME and the cancer-associated immune response.
Systematic Review and Pragmatic Clinical Approach to Oral and Nasal Vitamin B12 (Cobalamin) Treatment in Patients with Vitamin B12 Deficiency Related to Gastrointestinal Disorders
Authors: Andrès Emmanuel , Zulfiqar Abrar-Ahmad , Serraj Khalid , Vogel Thomas , Kaltenbach Georges
Published: September 2018

The objective of this review is to provide an update on the effectiveness of oral and nasal vitamin B12 (cobalamin) treatment in gastrointestinal (GI) disorders. Relevant articles were identified by PubMed and Google Scholar systematic search, from January 2010 and June 2018, and through hand search of relevant reference articles. Additional studies were obtained from references of identified studies, the Cochrane Library and the ISI Web of Knowledge. Data gleaned from reference textbooks and international meetings were also used, as was information gleaned from commercial sites on the web and data from CARE B12 research group. For oral vitamin B12 treatment, 4 randomized controlled trials (vs. intramuscular), 4 narrative and 4 systematic reviews, and 13 prospective studies fulfilled our inclusion criteria. These studies concerned patients with vitamin B12 deficiency related to: food-cobalamin malabsorption (n = 6), Biermer’s disease (n = 3), veganism or vegetarianism (n = 1), total gastrectomy after Roux-en-Y gastric bypass (n = 2) and Crohn’s disease (n = 1). Four prospective studies include patients with vitamin B12 deficiency related to the aforementioned etiologies, except veganism or vegetarianism. The systematic present review documents that oral vitamin B12 replacement, at a daily dose of 1000 μg (1 mg), was adequate to normalize serum vitamin B12 levels and cure main clinical manifestations related to vitamin B12 deficiency, in GI disorders, and thus, with safety profile. For nasal vitamin B12 treatment, only one preliminary study was available. We conclude that oral vitamin B12 is an effective alternative to intramuscular vitamin B12 (except in patients presenting with severe neurological manifestations). Oral vitamin B12 treatment avoids the discomfort, contraindication (in patients with anticoagulation), and cost of monthly injections.
Protein Kinase A Signaling Inhibits Iridophore Differentiation in Zebrafish
Authors: Cooper Cynthia D. , Erickson Steve D. , Yin Scott , Moravec Trevor , Peh Brian , Curran Kevin
Published: September 2018

In zebrafish (Danio rerio), iridophores are specified from neural crest cells and represent a tractable system for examining mechanisms of cell fate and differentiation. Using this system, we have investigated the role of cAMP protein kinase A (PKA) signaling in pigment cell differentiation. Activation of PKA with the adenylyl cyclase activator forskolin reduces the number of differentiated iridophores in wildtype larvae, with insignificant changes to melanophore number. Inhibition of PKA with H89 significantly increases iridophore number, supporting a specific role for PKA during iridophore development. To determine the effects of altering PKA activity on iridophore and melanophore gene expression, we examined expression of iridophore marker pnp4a, melanophore marker mitfa, and the mitfa repressor foxd3. Consistent with our cell counts, forskolin significantly decreased pnp4a expression as detected by in situ hybridization and quantification of pnp4a+ cells. Forskolin had the opposite effect on mitfa and foxd3 gene activity, increasing the area of expression. As mitfa/nacre mutants have extra iridophores as compared to wildtype larvae, we examined the function of mitfa during PKA-sensitive iridophore development. Forskolin treatment of mitfa/nacre mutants did significantly reduce the number of iridophores but to a lesser extent than that observed in treated wildtype larvae. Taken together, our data suggests that PKA inhibits iridophore development in a subset of iridophore precursors, potentially via a foxd3-independent pathway.
Path Planning for Aircraft Fleet Launching on the Flight Deck of Carriers
Authors: Li Yongtao , Wu Yu , Su Xichao , Song Jingyu
Published: September 2018

This paper studies the path planning problem for aircraft fleet taxiing on the flight deck of carriers, which is of great significance for improving the safety and efficiency level of launching. As there are various defects of manual command in the flight deck operation of carriers, the establishment of an automatic path planner for aircraft fleets is imperative. The requirements of launching, the particularities of the flight deck environment, the way of launch, and the work mode of catapult were analyzed. On this basis, a mathematical model was established which contains the constraints of maneuverability and the work mode of catapults; the ground motion and collision detection of aircraft are also taken into account. In the design of path planning algorithm, path tracking was combined with path planning, and the strategy of rolling optimization was applied to get the actual taxi path of each aircraft. Taking the Nimitz-class aircraft carrier as an example, the taxi paths of aircraft fleet launching was planned with the proposed method. This research can guarantee that the aircraft fleet complete launching missions safely with reasonable taxi paths.
A Reliable Method for Solving Fractional Sturm–Liouville Problems
Authors: Khashshan M. M. , Syam Muhammed I. , Al Mokhmari Ahlam
Published: September 2018

In this paper, a reliable method for solving fractional Sturm–Liouville problem based on the operational matrix method is presented. Some of our numerical examples are presented.
Sustainability of Information Security Investment in Online Social Networks: An Evolutionary Game-Theoretic Approach
Authors: Zhu Guang , Liu Hu , Feng Mining
Published: September 2018

With the rapid development of information technologies, security violations in online social networks (OSN) have emerged as a critical issue. Traditional technical and organizational approaches do not consider economic factors, which are increasingly important to sustain information security investment. In this paper, we develop an evolutionary game model to study the sustainability of information security investment in OSN, and propose a quantitative approach to analyze and optimize security investment. Additionally, we examine a contract with an incentive mechanism to eliminate free riding, which helps sustain the security investment. Numerical examples are provided for illustration and simulation purposes, leading to several countermeasures and suggestions. Our analytical results show that the optimal strategy of information security investment not only is correlated with profit growth coefficients and investment costs, but is also influenced significantly by the profits from free riding. If the profit growth coefficients are prohibitively small, both OSN service providers and online platforms will not choose to sustain investment based on small profits. As profit growth coefficients increase, there is a higher probability that game players will invest. Another major finding is that the (Invest, Invest) profile is much less sensitive to the change of profit growth coefficients and the convergent speed of this scenario is faster than the other profiles. The government agency can use the proposed model to determine a proper incentive or penalty to help both parties reach the optimal strategies and thus improve OSN security.
Multimodal Microstructure and Mechanical Properties of AZ91 Mg Alloy Prepared by Equal Channel Angular Pressing plus Aging
Authors: Yang Zhenquan , Ma Aibin , Liu Huan , Sun Jiapeng , Song Dan , Wang Ce , Yuan Yuchun , Jiang Jinghua
Published: September 2018

Developing cost-effective magnesium alloys with high strength and good ductility is a long-standing challenge for lightweight metals. Here we present a multimodal grain structured AZ91 Mg alloy with both high strength and good ductility, prepared through a combined processing route of low-pass ECAP with short-time aging. This multimodal grain structure consisted of coarse grains and fine grains modified by heterogeneous precipitates, which resulted from incomplete dynamic recrystallization. This novel microstructure manifested in both superior high strength (tensile strength of 360 MPa) and good ductility (elongation of 21.2%). The high strength was mainly attributed to the synergistic effect of grain refinement, back-stress strengthening, and precipitation strengthening. The favorable ductility, meanwhile, was ascribed to the grain refinement and multimodal grain structure. We believe that our microstructure control strategy could be applicable to magnesium alloys which exhibit obvious precipitation strengthening potential.
Analysis of Fracture Modes of Resistance Spot Welded Hot-Stamped Boron Steel
Authors: Zhao Yixi , Zhang Yansong , Lai Xinmin
Published: September 2018

Fracture modes of resistance spot welded ultra-high strength hot-stamped boron steel via lap-shear test are different from that of the traditional advanced high strength steel due to the difference in geometrical size and material property of the spot welds. In this paper, lap-shear fracture modes of resistance spot welding joints were analyzed and joint characteristics that affecting the fracture behavior were discussed. Three fracture modes were found to change from interfacial fracture (IF) to pull-out fracture (PF) with the increase of nugget diameter. For PF I mode, the fracture initiated at the transition zone between the fusion zone and upper-critical heat affected zone (HAZ) and propagated along the thickness of the nugget. For PF II mode, during which the failure initiated at the sub-critical HAZ where the softest zone occurred, and it propagated to the base material. Obvious hardness decrease was observed in the transition zone with the formation of the delta ferrite at the fusion boundary due to the relatively high amount of alloying element in the hot-stamped boron steel, which could provide the reason for route of PF I extending along this zone. Fluctuation in the hardness in the transition zone led to the existence of both PF I and PF II at the same welding current.
Effect of Ca Additions on Ignition Temperature and Multi-Stage Oxidation Behavior of AZ80
Authors: Cheng Chunlong , Lan Qing , Wang An , Le Qichi , Yang Fan , Li Xiaoqiang
Published: September 2018

AZ80, AZX801, and AZX802 alloys were prepared to investigate the ignition temperature and multi-stage oxidation behavior in air. Besides, the microstructures of alloys before and after oxidation were compared. The results reveal that AZX802 exhibits the characteristics of higher ignition temperature and best oxidation resistance compared to AZX801 and AZ80, which contributes to the increase of melting temperature of secondary phase in matrix due to the formation and increase of Al2Ca, with the addition of Ca in AZ80. In addition, the incubation periods before accelerated oxidation and the beginning of the accelerated oxidation temperatures of AZ80, AZX801, and AZX802 are different during multi-stage oxidation, which also contributes to the different onset melting temperature of the secondary phase. And the beginning of the accelerated oxidation of Mg alloys at high temperature is always accompanied by the onset melting of the low melting temperature of the secondary phase and the growth of oxide nodule on the surface.
Scandium Recovery from an Ammonium Fluoride Strip Liquor by Anti-Solvent Crystallization
Authors: Kaya Şerif , Peters Edward Michael , Forsberg Kerstin , Dittrich Carsten , Stopic Srecko , Friedrich Bernd
Published: September 2018

In this study, the crystallization of scandium from ammonium fluoride strip liquor, obtained by solvent extraction, was investigated using an anti-solvent crystallization technique. Acetone, ethanol, methanol and isopropanol were added individually to the strip liquor as the anti-solvent and scandium was precipitated and obtained in the form of (NH4)3ScF6 crystals. The results show that scandium can be effectively crystallized from the strip liquor to obtain an intermediate, marketable scandium product. Yields greater than 98% were obtained using an anti-solvent to strip liquor volumetric ratio of 0.8. Acetone had the least performance at lower anti-solvent to strip liquor volumetric ratios, possibly due to its limited H bonding capability with water molecules when compared to alcohols.
An Algorithm for Computing Side Chain Conformational Variations of a Protein Tunnel/Channel
Authors: Seo Udeok , Kim Ku-Jin , Kang Beom Sik
Published: September 2018

In this paper, a novel method to compute side chain conformational variations for a protein molecule tunnel (or channel) is proposed. From the conformational variations, we compute the flexibly deformed shapes of the initial tunnel, and present a way to compute the maximum size of the ligand that can pass through the deformed tunnel. By using the two types of graphs corresponding to amino acids and their side chain rotamers, the suggested algorithm classifies amino acids and rotamers which possibly have collisions. Based on the divide and conquer technique, local side chain conformations are computed first, and then a global conformation is generated by combining them. With the exception of certain cases, experimental results show that the algorithm finds up to 327,680 valid side chain conformations from 128~1233 conformation candidates within three seconds.