bluuebunny/crossref_metadata_2025 huggingface dataset:
Rapid anticancer drug screening using patient-derived lung cancer organoids: a case report
Authors: Cho Hyeong Jun , Lim Jeong Uk , Kim Seung Joon , Hwang Yongki , Park Jong Y. , Lee Dong Woo , Yeo Chang Dong
Published: April 2023

A variety of anticancer drugs and targeted agents for lung cancer have been developed, but some patients do not respond to these medications as intended. Therefore, there is an urgent need to develop a tool for predicting the anticancer drug response of each patient. Patient-derived tumor organoids (PDOs) have emerged as reliable in vitro tools for developing precision medicine. Herein, we describe a case of a 50-year-old nonsmoking man who was diagnosed with non-small cell lung cancer. Initially, no clinical symptoms were found in this patient. Postoperative pathology confirmed a stage Ib tumor, and an epidermal growth factor receptor (EGFR) mutation (exon21p.L858R) was detected in the patient’s lung tumor specimen. The patient later showed intracranial relapse 17 months after complete resection. An organoid culture was established from the resected brain metastatic tissue and a drug sensitivity test showed, within 72 hours, that the organoids were resistant to gefitinib and osimertinib. Our results recapitulated the patient’s response to anticancer drugs, demonstrating the potential of PDOs for precision medicine.
Türk Bankacılık Sektöründe Personelin Cinsiyet Çeşitliliğinin Kredi Riskine ve Kârlılığa Etkisi
Authors: PİLATİN Abdulmuttalip
Published: April 2023

Amaç: Bu çalışmanın amacı, Türk mevduat bankalarının cinsiyet çeşitliliğinin finansal performans üzerindeki etkisini incelemektir. Bu amaçla çalışmada kredi riski göstergesi olarak takipteki krediler (NPL) ile kredi zarar karşılıkları (LLP), iflas riski göstergesi olarak Z-Skor, kârlılık göstergesi olarak ise aktif kârlılık (RAO) ile öz sermaye kârlılığı (ROE) kullanılmıştır.

Yöntem: Yöntem olarak dirençli tahminciler kullanılarak sabit etkiler modeli uygulanmıştır.

Bulgular: Sonuçlar, bankaların cinsiyet çeşitliliğinin sektördeki bankaların kredi risk göstergesi olan NPL, LLP ve kârlılık göstergeleri olan ROA, ROE ile negatif ve anlamlı şekilde ilişkili olduğunu göstermektedir. Bankaların cinsiyet çeşitliliğinin bankaların kredi riskini önemli ölçüde azalttığı görülmüştür. Kârlılıklar bakımından ise cinsiyet çeşitliliği ile kârlılık arasında hipotezlerin aksine negatif ve anlamlı ilişki olduğu ortaya çıkmasına rağmen sağlamlık analizlerinde bankacılık sektöründe daha büyük paya sahip bankaların cinsiyet çeşitliliği ile kârlılıkları arasında pozitif ve anlamlı ilişkiler olduğu belirlenmiştir. Cinsiyet çeşitliliği ile kârlılık arasında doğrusal olmayan U şeklinde bir ilişki olduğunu anlaşılmıştır.

Özgünlük: Bu çalışma, bankaların farklı kademelerdeki cinsiyet çeşitliliğiyle ilgili olarak literatürde yapılmış olan ilk çalışmalardan biridir.
İstihdam, Reel Ücret ve Emek Verimliliği: Türkiye İmalat Sektörü Üzerine Bir Araştırma
Authors: KÖSE Tuna , AVCI Mehmet
Published: April 2023

Amaç: Reel ücret ve emek verimliliğinin istihdam üzerindeki etkisi literatürde tartışmalı bir konudur ve araştırmacılar arasında bir fikir birliği bulunmamaktadır. Türkiye imalat sektöründeki istihdam artışının önemli belirleyicileri arasında birçok makroekonomik değişken yer almaktadır. Bu çalışmada, Türkiye imalat sektörüne ilişkin 2009:Q1-2021:Q4 dönemini kapsayan veriler kullanılarak reel ücret, emek verimliliği ve istihdam arasındaki ilişki analiz edilmiştir.

Yöntem: Çalışmada değişkenler arasındaki kısa ve uzun dönemli ilişkinin varlığı ARDL Sınır Testi yardımıyla incelenmiştir.

Bulgular: Çalışma sonucunda, kısa dönemde istihdam ile hem reel ücretler hem de emek verimliliği arasında pozitif ve istatistiksel olarak anlamlı bir ilişki tespit edilmiştir. Uzun dönemde ise istihdam ile reel ücretler arasında pozitif ve istatistiksel olarak anlamlı bir ilişki tespit edilmiş olsa da istihdam ile emek verimliliği arasında istatistiksel olarak bir ilişki tespit edilememiştir. Elde edilen bulgular, Türkiye imalat sektöründe reel ücret ve emek verimliliği değişkenlerinin kısa dönemde istihdamın belirleyicileri arasında yer aldığını, uzun dönemde ise sadece reel ücret değişkeninden etkilendiğini göstermektedir.

Özgünlük: Bu çalışma reel ücret, emek verimliliği ve istihdam değişkenleri arasındaki dinamik ilişkiyi bir arada inceleyerek literatürdeki diğer çalışmalardan farklılaşmaktadır.
Trends and priorities in development of the field of technology transfer
Authors: Nikitin Iurii , Nochvai Volodymyr
Published: April 2023

In modern conditions of dynamic changes, the main trend in the development of the world economy and national economies is the presence of dominant factors characteristic of the development of an innovative economy, where the main source of innovation is science and education, which ensure sustainable economic growth through the implementation of innovations. Technology transfer is a key driver of industrial progress, increased productivity and competitiveness, and structural economic and social change. In the conditions of turbulent innovative development of the world economy and increasing needs for innovations that provide sustainable competitive advantages of economic growth, increasing efficiency and accelerating the transfer of scientific and technical developments is extremely necessary.
The main indicators of the state program «Digital Kazakhstan»
Authors: Mukanov Askar
Published: April 2023

Digitalization has become an essential aspect of daily life in Kazakhstan, and it is viewed as a critical strategy for promoting and speeding up economic growth in the country. The program "Digital Kazakhstan" focuses on the industrial trajectory of the digital transformation of the economy. The digital transformation involves incorporating digitalization into existing business models and structures to enhance their economic performance in a global market. Digital transformation has had a profound impact not only on the structures of public administration, medicine, and education, but also on numerous large and medium-sized entities within Kazakhstan's business sector. These are a number of enterprises of industry, energy, transport, logistics, agriculture, financial technologies and other areas of entrepreneurial activity. The potential of digitalization offers significant opportunities for the business environment, including access to new markets and channels, innovative technologies, and ideas, and the ability to increase productivity and utilize technical resources more efficiently. Therefore, digitalization can be considered as a new evolutionary step in the industrial transformation of the Kazakhstan economy. The establishment of digital transformation leads to a new era or industrial transformation, allowing businesses to track their activities, increase productivity, expand business strategies and interact with customers in the digital world. In the article, the authors analyze how digitalization affects economic indicators and serves as a measure to evaluate its effectiveness in driving technological advancements in different sectors of the economy.
Комунальні підприємства: договірні відносини та правові колізії
Authors: Гетьман Ольга , Сільченко Кирило
Published: April 2023

Договірні відносини між підприємствами, що надають житлово-комунальні послуги регламентуються чинним законодавством України. Але, на теперішній час існує ряд нерозв’язаних питань, зокрема питання щодо купівлі електричної енергії для забезпечення функціонування спільного майна багатоквартирних будинків та питання щодо обслуговування газорозподільних мереж будинків. Саме пошуку шляхів вирішення цих питань присвячена стаття.
Methodological issues for valuing wartime damages in Ukraine suffered by domestic enterprises due to the destruction and damage of fixed assets
Authors: Kulyk Andrii
Published: April 2023

Armed aggression in Ukraine emphasized the relevance of wartime damage valuation for both public and private sectors. Stakeholders from private sector are interested in damage valuation for the purposes of claiming for compensation in courts and presenting the information about revaluation and Impairment of assets in financial statements. Damage valuation for compensatory purposes poses a lot of uncertainty because requires development of relevant methodological framework as well as lacks practical cases on national grounds for application of damage valuation. Critical analysis of the methodological framework for wartime damages valuation indicates a number of shortcomings such as nor clear definition of the concept of “damage” and its link to actual losses and loss of profit, failure to account for economic obsolescence when estimating actual losses, lack of application of income and market approaches toward estimation of actual losses, rule-based approach toward calculation of lost profits, etc. By relying on international experiences of valuation for compensations’ claiming in courts, tribunals, arbitrages the author proposed a set proposals that might serve as potential solutions for existing methodological issues.
Застосування кольорової палітри для виконання технічних рисунків, а на їх базі електро-радіоелектронної апаратури
Authors: Анісімов Микола
Published: April 2023

В статті розглянуті застосування кольорової палітри для виконання технічних рисунків. Теоретична значимість цієї роботи полягає в тому, що Нами була розроблена технологія застосування того або іншого кольору у навчальному процесі для закріплення конкретних трудових дій учнів, а саме закріплення правильних навичок в процесі складання електричних схем. Були застосовані з колірної гами ті колірні відтінки, які дуже часто застосовуються в інших галузях.
Инновационные методы обучения как инструмент интернационализации высшего образования
Authors: Ван Ли Ван Ли
Published: April 2023

В статье уточняется понятие «инновация», в частности «образовательная инновация», анализируются отдельные инновационные методы обучения в вузе. Определены характерные различия традиционного и инновационного обучения, исследованы различные варианты классификации инновационных методов обучения, сформулированы основные подходы к выбору инновационных методов в соответствии с дидактической целью занятия, преимущества и недостатки использования отдельных методов.
Особливості моніторингу результатів попереднього навчання дітей мігрантів в країнах ЄС
Authors: Гут Наталя , Щербань Ірина
Published: April 2023

У статті окреслено основні виклики, з якими стикаються країни Європейського союзу, коли йдеться про інтеграцію дітей-мігрантів у систему формальної освіти, проаналізовано кращі практики проведення процедури оцінювання результатів попереднього навчання новоприбулих учнів. Вказано, що моніторинг освітньої траєкторії не є обов’язковим, не має уніфікованої процедури та може здійснюватися за допомогою різноманітних механізмів, але є важливим для забезпечення ефективної освітньої підтримки дітей мігрантів в освітніх установах приймаючих країн.
Features of the self-concept of the elderly
Authors: Spytska Liana
Published: April 2023

The study of the self-concept in late adulthood seems an essential topic. This happens since people's lives are becoming longer. The number of older people is increasing, and the correct interaction with the younger generation is possible with a deep understanding of the specifics of their age psychology. The self-concept develops throughout a person's life and absorbs everything that was the most significant in each of the periods of personal development. Therefore, the self-concept of late adulthood and old age is a complex formation in which information about the many self-images that arises in a person in various variants of his self-perception and self-representation is "recorded." This is a selective memory of the individual, reflecting events so as not to disturb prominent personal positions. Therefore, it is challenging to investigate the self-concept of a particular person in his life transformation.
About the genre specificity of the plays «Guests» («Gäste») by Oliver Bukowski and «The Ugly One» («Der Hässliche») by Marius von Mayenburg: from the author's definition to the reception of critics and viewers
Authors: Yuhan Nataliia
Published: April 2023

The plays "Guests" ("Gäste") by Oliver Bukowski and Marius von Mayenburg's "The Ugly One" ("Der Hässliche") reflect the most important genre processes that are typical for the historical and world literary development of drama at the end of the 20th – beginning of the 21st century: the individualization of the genre of each individual play; active hybridization of genres of dramaturgy; the processes of genre transformation, genre convergence and genre diffusion, etc. Modern German drama at this stage of its development is becoming fundamentally dialogic, open to reader / audience interpretations and theatrical reinterpretations. The literary approach implemented in this article – in the paradigm from the author's genre definition to the analysis of the audience's perception of the director's productions of plays – allows a deeper understanding, first of all, of the ideological and artistic originality of a literary work.
Арабський фемінізм: формування, сучасні напрями, представники у літературному процесі
Authors: Заза Юлія , Скаб Юлія
Published: April 2023

У статті було розглянуто визначення терміну “фемінізм” арабською мовою; було показано напрями та течії сучасного фемінізму в арабських країнах та описано специфіку кожного з них; окреслено етапи становлення арабського жіночого руху. Окремо розглянуто, які саме літератори належать до представників феміністичного руху. На прикладах творів Нізара Каббані та Халіля Свейлеха було показано окремі риси, якими змальовано сучасний арабський феміністичний образ.
Необхідність вдосконалення та гармонізації з європейським законодавством законів України та інших актів, що стосуються охорони здоров’я. Реалії сьогодення
Authors: Білецька Інна
Published: April 2023

Необхідність удосконалення та гармонізації законів України та інших нормативно-правових актів у сфері охорони здоров'я з європейським законодавством є актуальним питанням сьогодення, оскільки це забезпечить отримання громадянами України якісних медичних послуг, що відповідають європейським стандартам, та дасть змогу Україні ефективніше інтегруватися до Європейського Союзу. Метою цієї роботи є дослідження необхідності вдосконалення та гармонізації законів України та інших нормативно-правових актів, що стосуються охорони здоров'я, з європейським законодавством.
Leveraging random forest techniques for enhanced microbiological analysis: a machine learning approach to investigating microbial communities and their interactions
Authors: Chrobak Daria , Kołodzieczak Maciej , Kozlovska Polina , Krzemińska Adrianna , Miller Tymoteusz
Published: April 2023

The rapid development of high-throughput sequencing technologies has led to an explosion of microbiological data, presenting new challenges and opportunities for understanding microbial processes and interactions. Machine learning techniques, such as the Random Forest algorithm, offer powerful tools for analyzing these large and complex datasets, providing valuable insights into microbial ecology, physiology, and evolution. In this study, we applied the Random Forest algorithm to microbiological data, focusing on data collection, preprocessing, feature selection, and model evaluation to ensure accurate, reliable, and meaningful results. Our findings demonstrated the effectiveness of the Random Forest algorithm in capturing complex relationships between microbial features and the target variable, contributing to the ongoing development of innovative solutions to pressing challenges in microbiology research and applications. Future work should explore the use of advanced machine learning techniques, integration of multi-omics data, and interdisciplinary collaborations to fully harness the potential of machine learning for advancing our understanding of microbial systems and their implications for human health, environmental sustainability, and biotechnological innovation.
Chirurgia laparoscopică a rinichiului
Authors: Chirnicinîi Mihai
Published: April 2023

Importanța acestui studiu constă în prezentarea eficacității chirurgiei laparoscopice a rinichiului în tratamentul chistului renal față de intervențiile urologice deschise. Actualitatea studiului se datorează potențialului foarte înalt a metodelor laparoscopice în tratamentul chisturilor renale, care prezintă avantaje mari atât față de metodele de puncție, cât și față de intervențiile deschise, laparoscopia devenind un domeniu major în chirurgia urologică.
Optical Coherence Tomography-guided intravitreal bevacizumab in the treatment of refractory pseudophakic cystoid macular edema – case study
Authors: Gahramanov Hafiz , Zulfiyev Gabil , Shahbazov Jahid , Aghayev Elgun
Published: April 2023

One of the serious vision threatened complications of cataract surgery is refractory PCME. That is why this complication has to be managed in time and adequately. Non steroidal and steroidal antiinflammatory and anti VEGF agents like bevazicumab are useful for refractory PCME. OCT has an important role in detecting PCME and measurement of central macular thickness to control the treatment of PCME. In this case study patient after rutin uncomplicated FACO surgery with refractory PCME at postop 4-th week is described. Despite of using of topical NSAID+steroidal antiinflammatory treatment there was no improvement in decreased vision and CMT was remained stable increased (811 mmk). Vision was increased only after 2 week of i/v bevazicumab injection, macular edema resolved and CMT decreased (280 mmk) which was revealed by OCT. In conclusion, OCT quided i/v bevacizumab is safe and well tolerated treatment option for refractory PCME.
Аналіз асортименту лікарських засобів для лікування кашлю
Authors: Присяжнюк Дар’я , Олійник Світлана , Ярних Тетяна , Пуль-Лузан Вікторія
Published: April 2023

Негативний вплив кашлю на організм людини різноманітний: це і підвищення внутрішньогрудного та внутрішньобронхіального тиску з подальшим формуванням емфіземи легень; негативний вплив на кровоносну систему, що виникає за рахунок зменшення присмокту вальної дії грудної клітки – утруднення припливу крові до серця і розвиток серцево-легеневої недостатності. Крім того, підвищення венозного тиску під час кашлю веде до виникнення дрібних крововиливів у слизовій оболонці очей. Кашель може призвести до кровохаркання, пневмотораксу і особливо важливо – до зниження якості життя хворого. Саме тому вибір раціональної протикашльової терапії є особливо актуальним.
Устойчивое развитие на основе циркулярной экономики
Authors: Wang Qingyuan
Published: April 2023

В статье актуализируются вопросы устойчивого развития в контексте реализации принципов и моделей циркулярной экономики, показана роль цифровых технологий в содействии переходу к экономике замкнутого цикла и предлагают основу для циркулярной экономики 4.0. На взгляд автора, интеграция цифровых технологий может улучшить подходы и модели циркулярной экономики, обеспечивая более эффективное использование ресурсов, улучшенное отслеживание материалов, а также лучший мониторинг воздействия на окружающую среду. Циркулярная экономика рассматривается как перспективный подход к устойчивому развитию путем продвижения таких практик, как переработка ресурсов и минимизация использования энергии.
Installation of integrated intellectual information security systems in open corporate networks – DDoS attack
Authors: Mammadova Kifayat , Aslanov Rahim
Published: April 2023

Securing information security in open corporate networks is crucial, and building defense systems against potential threats is a critical step towards ensuring the availability, completeness, and confidentiality of system clients. Integrated information security systems play a pivotal role in safeguarding an organization's assets by identifying and mitigating security vulnerabilities. Therefore, it is essential to be aware of the various types of attacks that may be directed towards an information system and analyze them to prevent and mitigate the impact of such attacks. By taking proactive measures to protect against DDoS attacks and other types of cyber-attacks, organizations can minimize the risk of downtime, data breaches, and financial loss, ensuring the integrity, availability, and confidentiality of their systems and clients.
Methods and models of organization and processing of data and knowledge in an intelligent decision support system for the identification of cultural values
Authors: Martynenko Andrii
Published: April 2023

The problem of developing an intellectual decision support system for the identification of cultural values (on the basis of works of art), the issue of choosing and justifying methods and tools for its construction is considered. Methods of research and construction of complex objects, prospects of using similar systems based on modern artificial neural networks as a tool for developing an intelligent decision support system are considered. Considerable attention is paid to the issues of methods of automatic identification and classification of works of art, as the main elements of an intelligent decision support system. Prospects and ways of further research and use of this subject area are also defined.
The formation of emotional stability of students in physical education
Authors: Pichurin Valerii , Umerenko Viktor , Dutko Taras
Published: April 2023

One of the directions for improving the training of future specialists in higher education institutions is the formation of professionally relevant personality characteristics. Emotional stability is one of these characteristics. Physical education and sport are one of the few spheres of life of modern students in which this issue can be effectively resolved. The authors provide data on the positive impact of specially organized physical education classes on the formation of such emotional stability in students.
Організаційно-методичні особливості занять з черлідингу в процесі фізичного виховання учнів старшої школи
Authors: Базилевич Наталія , Гордієнко Олександр , Криволап Олександр
Published: April 2023

В статті розкриваються організаційно-методичні особливості занять черлідингом учениць старшої школи в процесі урочної та позаурочної роботи з фізичного виховання. Зроблено експериментальну перевірку впливу занять з черлідингу на фізичну підготовленість та функціональний стан старшокласниць. Доведена ефективність запровадженої методики занять черлідингом в процесі фізичного виховання учнів старшої школи.
TECHNOLOGICAL DISRUPTION AND DEPOSIT MONEY BANKS FINANCIAL PERFORMANCE IN THE PRE AND POST COVID-19 PANDEMIC IN NIGERIA
Authors: MBAGWU, Onyinyechi Nneka  , OBONOFIEMRO, Godwin
Published: April 2023

The study examined the relationship between technological disruption and deposit money banks financial performance in the pre and post covid-19 pandemic in Nigeria for the period of 2000-2020 (21years). This was done respect of measures of technological disruption, namely; Automated Teller Machine (ATM), Internet Banking (INTB), Point of Sales (POS) and Mobile Transactions (MTs) and how they affects deposit money banks financial performance of in Nigeria {proxy with Return on Assets (ROA)}. The method of data collection used in this study is the secondary source of data (time series data), from the CBN Bank Supervisory Annual Report, CBN Statistical Bulletin and Nigeria Deposit Insurance Corporation (NDIC) Annual Reports for the period 2000-2020. The data set was described using descriptive statistics and the unit root test was conducted to ascertain if the data are stationary in order to have accurate regression result. The correlation analysis will be use to ascertain the co-movement of the independent variables in relation to the dependent variable while the Multiple Regression analysis were employed with the aid of E-VIEW version 9.0 for the purpose of testing the research hypotheses raised. The finding revealed that Automated Teller Machine (ATM), Internet Banking (INTB), Point of Sales (POS) and Mobile Transactions (MTs) have positive and significant effect on Return on Assets (ROA) of deposit money banks in Nigeria. Hence, the study concluded that technological disruption has significant positive effects on deposit money banks financial performance in the pre and post covid-19 pandemic in Nigeria. Based on the findings, the study recommended that deposit money bank management should pay more attention on the activities that will improve the technological disruption channels of their banks if they wish to increase the ROA value of their banks as this will lead to high customer’s satisfaction and patronage.

Keywords: Technological Disruption, Financial Performance, Deposit Money Banks and Pre and Post COVID-19 Pandemic.
Syria: Do Complex Agricultural Interventions Strengthen Food Security?
Authors: Baliki Ghassan , Brück Tilman , Ghattas Hala
Published: April 2023

This evidence brief reports on the analysis of the impacts of a complex agricultural intervention on households’ food security status as well as agricultural crop and livestock production in a humanitarian setting. The authors consider income generated from agricultural value chain activities and individuals’ use of harmful livelihood strategies to cope with shortages of food. The impact analysis adopts a quasi-experimental approach using household survey data collected from beneficiary (treatment group) and non-beneficiary (control group) households in Syria before, during and after the interventions took place (3 waves in total). They also explore whether the outcome indicators vary meaningfully by gender and by access to irrigation.
Complements and Alternatives to RCTs in evaluation in development
Authors: Attanasio Orazio , Cavatorta Elisa
Published: April 2023

Randomised control trials (RCTs) have attracted increasing attention in evaluation of public policy. They have become some sort of gold standard to determine “what works” in international development. However, in some cases, the key feature of RCTs – the random allocation of treatment(s) – may be unethical, politically infeasible, or simply impossible. This paper discusses the main barriers to answer causal questions of key interest in policy evaluation. It then reviews approaches complement to RCTs which can be used to answer evaluation questions in conjunction with RCTs and alternatives useful whenever RCTs are not applicable. The paper discusses issues in drawing causal inference from these alternative approaches and provides some examples from specific sectors where standard RCTs are less likely to be applicable.
Approaches to evidence synthesis in international development
Authors: Oliver Sandy , Gough David , Copestake James
Published: April 2023

This paper discusses the spectrum of synthesis methods available to generate, explore and test theory, their value to the field of international development and innovations required to make better use of the primary research available. It goes further than setting substantive priorities for international development impact and learning. It addresses current advances and priority gaps in the methods for research before considering the substantive and methodological direction of evidence synthesis for impact evaluation in international development, particularly as this relates to the work of CEDIL. This scope encompasses methods for all stages in the process, from setting the question to appraising and synthesising the findings. It describes existing methods for synthesis, including how methods vary and the guidance and standards available. It then considers how well existing methods match the field of international development and the latest innovations emerging or required before providing a research agenda for advancing synthesis methods. In particular, it argues for clearer distinctions between syntheses produced as public goods, and those tailored to specific circumstances; and strengthening knowledge systems through greater use of maps to navigate existing and missing evidence, harmonised outcomes and measures, and advances in automation technologies. Improved methods and guidance are required for synthesising formative research and investigating contextual factors. Engaging stakeholders and working across academic disciplines support the production of policy-relevant syntheses and inspire methods development.
Massive sediment pulses triggered by a multi-stage alpine cliff fall (Hochvogel, DE/AT)
Authors: Barbosa Natalie , Leinauer Johannes , Jubanski Juilson , Dietze Michael , Münzer Ulrich , Siegert Florian , Krautblatter Michael
Published: April 2023

Abstract. Massive sediment pulses in catchments are a key alpine multi-risk component. Substantial sediment redistribution in alpine catchments frequently causes flooding, river erosion, and landsliding, and affects infrastructure such as dam reservoirs as well as aquatic ecosystems and water quality. While systematic rock slope failure inventories have been collected in several countries, the subsequent cascading sediment redistribution is virtually unaccessed. This contribution reports for the first time the massive sediment redistribution triggered by the multi-stage failure of more than 150,000 m3 from the Hochvogel dolomite peak during the summer of 2016. We applied change detection techniques on seven 3D-coregistered high-resolution true-orthophotos and digital surface models (DSM) obtained through digital aerial photogrammetry later optimized for precise volume calculation in steep terrain. The analysis of seismic information from surrounding stations revealed the temporal evolution of the cliff fall. We identified the proportional contribution of > 600 rockfall events (>1 m3) from 4 rock slope catchments with different aspects and their volume estimates. In a sediment cascade approach, we evaluated erosion, transport, and deposition from the rockface to the upper channelized erosive debris flow channel, then to the widened dispersive debris flow channel, and finally to the outlet into the braided sediment-supercharged Jochbach river. We observe the decadal flux of more than 400,000 m3 of sediment with massive sediment pulses that (i) respond with reaction times of 0–4 years and relaxation times beyond 10 years, (ii) with faster response times of 0–2 years in the upper catchment and more than 2 years response times in the lower catchments, (iii) the inversion of sedimentary (102–103 mm/a) to massive erosive regimes (102 mm/a) within single years and the (iv) dependency of redistribution to rainfall frequency and intensity. This study provides generic information on spatial and temporal patterns of massive sediment pulses in highly-charged alpine catchments.
Wstęp
Authors: Tomaszewski Tadeusz
Published: April 2023

Szanowni Państwo, drodzy Czytelnicy,wychodzimy wreszcie z trudnego dla całego kraju i nas wszystkich okresu związanego z pandemią COVID-19, co daje nadzieję na normalność i powrót do pracy. Na szczęście ograniczenia związane z pandemią nie wpłynęły na zapał do działań twórczych naszych Autorów i obecnie możemy, jak zawsze z satysfakcją, przekazać do rąk naszych Czytelników nowy numer periodyku „Problemy Współczesnej Kryminalistyki”. Jest to już jego XXVI tom, równie ciekawy i bogaty w różnorodne tematycznie opracowania jak poprzednie, który powinien zainteresować szerokie grono kryminalistyków, prawników i studentów kilku co najmniej kierunków studiów, a-także przedstawicieli tych wszystkich dyscyplin, które wspomagają naukę kryminalistyki lub praktykę śledczo-sądową. Utrzymujemy zarazem zasadę, że nasi Autorzy reprezentują różne ośrodki naukowe i eksperckie, w tym zagraniczne; większość z- nich dzieli się swoją wiedzą i doświadczeniem praktycznym opartym na wieloletnim wykonywaniu zawodów wykorzystujących wiedzę kryminalistyczną i-z-pogranicza innych dyscyplin sądowych, ale wśród Autorów artykułów są też młodsi stażem zawodowym niedawni absolwenci studiów, których badania przeprowadzone na użytek prac dyplomowych wydały nam się tak ciekawe, że zaprosiliśmy ich do współpracy. Jednocześnie miło nam poinformować, że od obecnego numeru wszystkie prace ogłaszane drukiem w „Problemach…” publikowane są zarównow języku polskim, jak i angielskim. Mamy nadzieję, że to w znaczący sposób poszerzy grono naszych Czytelników i pozwoli na dotarcie polskiej myśli kryminalistycznej do zagranicznych ośrodków.
Sędzia pokoju w Polsce: jeżeli tak, to jaki?
Authors: Rojek Włodzimierz
Published: April 2023

W dobie debaty publicznej na temat celowości wprowadzenia urzędu sędziego pokoju praca niniejsza pokusiła się o przedstawienie kilku aspektów tej instytucji wymiaru sprawiedliwości. Poczynając od definicji sędziego pokoju, przez krótki zarys historii tego urzędu sędziowskiego w Polsce, stanowi podstawę dla prezentacji przemyśleńi wiedzy autora, który dzieli się swoimi pomysłami na kształt omawianej instytucji. Warto wspomnieć, że autor jest sędzią pokoju w Kanadzie od 1993 r., a wcześniej był sędzią sądów rejonowych i sądu wojewódzkiego w Polsce. Koncepcja pracy jest oparta na wypunktowaniu ram prawnych, które musiałyby zdefiniować sposób powołania, odwołania i umiejscowienia sądów (sędziów) pokoju w strukturze wymiaru sprawiedliwości. Zdaniem autora urząd sędziego pokoju powinien zapewniać dostęp do niezawisłego sądu zgodnie z konstytucją, Kartą praw podstawowych Unii Europejskiej oraz Europejską konwencją o ochronie praw człowieka i podstawowych wolności. Obywatel ma bowiem prawo do sprawiedliwego, jawnego rozpoznania sprawy, które nie może też być w nieuzasadnionym stopniu przewlekłe. Jeżeli sądy pokoju powstaną w Polsce, powinny spełniać te kryteria.Praca analizuje dwa sposoby powoływania sędziów pokoju. Autor odnosi się do pomysłu zawartego w prezydenckim projekcie stosownej ustawy, czyli wyboru sędziów pokoju na 6-letnie kadencje, jak też możliwości powoływania ich w drodze mianowania. Przedstawia także kryteria, jakie kandydat na to stanowisko powinien spełnić, oraz zakres spraw przekazanych do rozpoznawania przez sędziów pokoju. W celach porównawczych opisano zakres właściwości rzeczowej sędziów pokoju w Kanadzie. Podano też dane statystyczne, pokazujące, w jakim stopniu powołanie sędziów pokoju odciążyłoby sądy rejonowe.
Multicultural Approach: A Strategy towards Transforming African Americans’ Social Status and Countering Racial Agenda in The Sellout by Paul Beaty
Authors: Ahmed Abrar , Dur e  Afshan  , Farooq Athar
Published: April 2023

Racial essentialists created race as a propaganda of racism and after realizing this, the oppressed community has taken its rise towards the zenith of social transformation and respect. Growing injustice and oppressive biasness of whiteness created zeal in black people to stand against marginalizing forces and counter prejudice around them. The paper aims at analyzing new journey of African Americans’ transformation towards multiculturalism by getting away with cultural particularism that is restricting their communal circle. This paper investigates their efforts to omit racial, social, and ethnic differences and create plural and multicultural society as source of withstanding their rejection and exclusion in the Sellout by Paul Beatty. The study is quantitative in nature and develops a framework through multicultural stance of postmodernism.  The finding reveals that the novel presents the efforts of the protagonist of the novel and African Americans in countering biasness around them by striving for multicultural society by operating beyond any social, cultural, and racial differences.
LUARAN PASIEN STROKE ISKEMIK AKUT DENGAN INFEKSI COVID-19 DI JAKARTA
Authors: Ida Chahyani Wiwit , Sri Hastuti Murni , Malika Malika , Rahmi Izati , Regina Rachmawati Maria , Wardy Warongan (alm) Anwar , Airiza Ahmad Siti
Published: April 2023

ABSTRAK

 Pendahuluan: Stroke iskemik merupakan salah satu komplikasi neurologis dari infeksi Corona Virus Disease 19 (COVID-19) yang mengancam nyawa. Penelitian mengenai luaran pasien stroke iskemik akut dengan infeksi COVID-19 di Indonesia belum banyak dilaporkan.

Tujuan: Peneliti ingin mengetahui bagaimana luaran pasien stroke iskemik akut dengan infeksi COVID-19 dan faktor apa saja yang mempengaruhi luaran tersebut di Rumah Sakit Umum Daerah (RSUD) Pasar Minggu, sebagai salah satu rumah sakit rujukan khusus COVID-19 di Jakarta.

Metode: Penelitian ini merupakan studi potong lintang yang bersifat deskriptif analitik menggunakan data rekam medis pasien stroke iskemik akut dengan infeksi COVID-19 berusia      ≥18 tahun yang dirawat di RSUD Pasar Minggu periode Maret 2020-Juni 2021. Analisis statistik menggunakan uji Chi Square dan uji T tidak berpasangan.

Hasil: Didapatkan 36 subjek yang memenuhi kriteria penelitian. Mayoritas berusia ≥50 tahun (69,4%), perempuan (58,3%), nilai National Institute of Health Stroke Scale (NIHSS) ≤5 (52,8%). Luaran pasien stroke iskemik akut dengan infeksi COVID-19 yaitu mortalitas 16,7% dan bagi subjek yang hidup nilai median mRS saat pulang adalah 2(1-5). Terdapat hubungan yang bermakna antara derajat penyakit COVID-19 dengan mortalitas pasien stroke iskemik akut yang terinfeksi COVID-19 (p=0,019; rasio Odds 1,5 dengan interval kepercayaan/ IK 95% 1,08-2,08).

Diskusi: Mortalitas pasien stroke iskemik akut dengan infeksi COVID-19 cukup tinggi dan faktor yang mempengaruhinya secara bermakna adalah derajat penyakit COVID-19. Pasien stroke iskemik akut dengan infeksi COVID-19 yang hidup sebagian besar memiliki disabilitas ringan.

Kata Kunci: COVID-19, luaran , stroke iskemik.
Severe Atypical Pneumonia in an Adolescent -
A Case Report
Authors: Budensab Amal
Published: April 2023

Mycoplasma pneumonia is one of the commonest causes of community acquired pneumonia in young adults. We report a case of atypical pneumonia with respiratory distress.

Key words: Mycoplasma pneumoniae, Pneumonia
Universal Height Measurement Jig
Authors: Biswal Subhasmita , Pradhan Rojaleen , Sahoo Subhasmita
Published: April 2023

In the field of prosthetics and orthotics, compensation is very widely used. There are various examples that how the compensation blocks play a vital role to access the shortening of the limb length and pelvic obliquity. Height is an important factor for the prosthetic cosmesis appearance, which provides the patient self-confidence to feel the equality in the society. The objective of the study was to design and develop a universal height measuring jig and find out the compensation required for the specific LLD and to decide the length from MPT to floor after initial socket fitment in case of trans-tibial amputee. To equalize both normal and affected side to prevent pelvic obliquity. In this height measurement jig, mainly a car jack was used for height adjustment. During this process to minimize the stress and for easy adjustment an extended lever with rounded handle was aligned centrally with the car jack. For accurate vertical liner measurement, a steel measurement tape was used. It is a Portable device with minimum mechanical arrangements with less Economic and easy to operate due to long lever arm. This type of universal device resolves the issue raised by the error occur during conventional measurement methods.

Key words: leg length discrepancy, Height adjustment jig, Car jack, pelvic obliquity.
Enforcement of Labor Wages Below the Minimum Standard Reviewed from Government Regulation (PP) Number 36 of 2021 concerning Wages and Islamic Law
Authors: Nurhayati Siti , Wakhyuni Emi , Asmi Hasibuan Syaiful
Published: April 2023

The implementation of labor wages should be adjusted to the minimum wage set by the government, but the implementation of labor wages below the minimum standard carried out by several companies is interesting to study the implementation of labor wages below the minimum standard that is justified, considering that wages are an important aspect for workers to be able to live a decent life. The suspension of the minimum wage is a way out for companies that have not been able to meet the minimum wage payments. This applies before the passing of the Job Creation Law, where companies can apply for suspension of minimum wage payments to the local Governor/Regional Head. Then in order to ensure the ability and sustainability of a company, Law Number 11 of 2020 concerning Job Creation which was later clarified by PP Number 36 of 2021 concerning Wages contains new provisions, namely that the minimum wage is excluded for micro and small businesses with certain provisions and criteria. In the regulation, it is explained that companies are required to provide wages as the minimum wage that has been determined and there are sanctions for companies that do not run it.Regarding wages in Islamic law, the determination of wages (ujrah) of workers strictly upholds the principles of justice and sufficiency. The main principle of justice lies in the clarity of the contract (transaction) and commitment on the basis of willingness to do it (from the contractor). Therefore, Islam strongly prioritizes the principle of justice in all aspects including economic aspects, especially in determining wages for workers or laborers, so it is necessary to have a work agreement between workers and employers so that there is no arbitrariness of employers against their workers. The provision of time in work determined, as well as the amount of the wage payment system and the reference amount of wages that must be issued, is a very striking general difference from the concept used in Islamic Law and Government Regulation Number 36 of 2021 concerning Wages.

Keywords: Wage, Labor, Government Regulation (PP), Islamic Law
The Effect of Using Discovery Learning-Based Mathematics Learning Modules on Students' Interest in Learning Mathematics
Authors: Ramadhani Muhammad Habib , . Kartono , Haryani Sri
Published: April 2023

The purpose of this study was to analyze the effectiveness of the discovery learning-based mathematics learning module in terms of students' interest in learning mathematics. This type of research is quasi-experimental. The research design used was the One Group Pretest-Posttest Design. The research was conducted in class V SDN Ngijo 02 Gunungpati District, Semarang City. The number of students in the class is 28 students. The instrument used in the study was a questionnaire of interest in learning mathematics. Data analysis techniques used parametric statistical tests t-test and N-Gain. The statistical test results showed that the significance value was 0.00, meaning that the average score of students' learning interest after using the discovery learning model-based mathematics learning module was higher than the average score of students' learning interest before using the discovery learning model-based mathematics learning module. The average interest in learning mathematics in class V at SDN Ngijo 02 experienced an n-gain increase of 0.45 with the "medium" criterion. Thus, it can be concluded that the use of discovery learning model-based mathematics learning modules in learning has proven to be effective in increasing interest in learning mathematics for fifth-grade students at SDN Ngijo 02.

Keywords: learning modules, mathematics, discovery learning, interest in learning
INCIDENCIA DE LEISHMANIASIS EN PACIENTES DEL MUNICIPIO DE REYES BENI-BOLIVIA 2010-2011
Authors: Olguin Ávila Mauricio , Camacho Yañez Carla
Published: April 2023

Leishmaniasis es una de las enfermedades más importantes transmitida por vectores, en humanos. Esta parasitosis puede ser causada por muchas especies de Leishmania, la mayoría de las cuales son zoonóticas. En humanos, diferentes especies de parásitos están asociadas a diferentes formas de la enfermedad. 

Esta enfermedad contribuye considerablemente a incrementar la pobreza porque su tratamiento es caro y, por lo tanto, resulta inasequible o impone una carga económica sustancial. De ahí el objetivo del presente estudio, de encontrar la frecuencia de casos confirmados en un lugar endémico, Reyes-Beni.

Se realizó un estudio descriptivo retrospectivo en el Hospital San Juan de Dios en la provincia Ballivián en el departamento del Beni. Se encontraron un total de 22 pacientes registrados con Leishmaniasis durante las gestiones 2010 al 2011, con un porcentaje del 92% de sexo masculino y solo el 8% de sexo femenino, del cual el 100% fue diagnosticado, controlado y tratado.

Se determinó que la Leishmaniasis es una patología que si no se previene o no se da tratamiento adecuado y oportuno, las complicaciones pueden ser muy peligrosas. Se pudo observar que en esta región la Leishmaniasis cutánea es de mayor predominio en personas de edad promedio, que el sitio de predilección para la infección del vector se encuentra en miembros inferiores, en personas de sexo masculino, principalmente agricultores. Se determinó que la comunidad de mayor incidencia de casos confirmados es Puerto Cavinas.
MODIFICACIONES DE PERFIL INICIAL EN PACIENTES SOMETIDOS A CIRUGIA ORTOGNÁTICA 2010-2012 MÉXICO - DF 2006.
Authors: Arancibia Bolaños Carolina Arali , Porras Valero Franklin Alexi
Published: April 2023

Los tratamientos realizados a pacientes con cirugía ortognática, tienen la tendencia a producir cambios a nivel de los tejidos blandos o en el perfil del paciente como consecuencia del tratamiento de ortodoncia y la cirugía ortognática realizada. El propósito de este trabajo es determinar cuáles son los cambios que se producen en el perfil del paciente sometido a cirugía ortognática, mediante un estudio descriptivo, observacional y transversal.

Para este trabajo se tomaron en cuenta a los pacientes que fueron sometidos a estos procedimientos, en los que se analizaron los ángulos naso-labial y mento-labial, para determinar el perfil inicial y los cambios que se presentaron posteriores a la cirugía ortognática; de este modo se determinaron los cambios que existen en estos pacientes antes y después del tratamiento ortognático. Fueron tomados 30 pacientes con alteraciones cráneo-faciales marcadas, los cuales requerían de un tratamiento que mejore su oclusión, estética y también su calidad de vida, por el rechazo constante que para ellos presentaba debido a su apariencia facial inicial.

Los cambios que se producen son en los ángulos naso-labial y mento-labial por el tratamiento ortodóncico combinado con cirugía ortognática, modificándose el perfil del paciente una vez concluido el tratamiento, dando como resultado un perfil armónico, estético y próximo a la norma, que en este caso, es el perfil de un paciente clase l, con perfil recto.
INCIDENCIA DE INTOLERANCIA A LA GLUCOSA Y GLUCOSA EN AYUNO ALTERADA EN ESTUDIANTES DE LA UNIVERSIDAD DE COLIMA, MÉXICO
Authors: Austria Tejeda Jabih Armantina , López Madrigal Raúl César Iván , López Ascencio Raúl , Del Toro Equihua Mario , Bautista Hernández Víctor Manuel , Velasco Rodríguez Raymundo , Vásquez Clemente
Published: April 2023

La glucosa en ayuno alterada y la intolerancia a la glucosa son dos formas clínicas catalogadas como fases prediabéticas y tienden a aumentar con la edad y la obesidad. El objetivo del presente estudio fue determinar la prevalencia de estas formas clínicas en estudiantes de la Universidad Colima, México.

Se realizó un estudio transversal, en el cual participaron 59 estudiantes de la Universidad de Colima, México. Se realizaron mediciones de glucosa en ayuno y poscarga con 75g de glucosa, tomándose lecturas de glucosa a los 30, 60, 90 y 120 minutos poscarga. Se consideró como normoglucémicos con cifras en ayuno menores a 100 mg/dl, con glucosa en ayuno alterada si las cifras estaban entre 2100 mg/dl y < 126 mg/dl, para la intolerancia a la glucosa las cifras tenían que estar entre 2140 mg/dl y <200 mg/dl a 120 minutos de poscarga y para Diabetes Mellitus tipo 2 con cifras de glucosa mg/dl en cualquier momento poscarga.

La presencia tanto de glucosa en ayuno alterada, intolerancia a la glucosa y Diabetes Mellitus tipo 2 se incrementó con el peso de los participantes, sin embargo el hecho de tener normo peso o bajo peso no excluyó la presencia de estas formas clínicas.