bluuebunny/crossref_metadata_2025 huggingface dataset:
The influence of elementary school students’ anthropomorphism of AI on the attitude and the career hope toward AI
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Cho Soo Kyung , Cho Young Hoan , Kim Hyeeun , Kim Hyeongjo
Published: September 2022

Objectives This study intends to explore students’ anthropomorphism, attitude, and career hope about AI in order to get implications for AI literacy education.
Methods This study conducted interviews with 27 elementary school students in the fourth to sixth grades who had the experience of AI education. We analyzed the interviews not only in a qualitative way but also in a quantitative way by quantifying the interviews and carrying out Fisher’s exact test in order to explore the relationships among anthropomorphism, attitude, and career hope about AI.
Results Elementary school students were likely to perceive AI as creative as a human being although they somewhat disagreed that AI had emotion, self-willingness, and general intelligence. This study found individual differences in the anthropomorphism of AI, which influenced students’ attitude toward AI. Students, who believed that AI had emotion, were more likely to have a positive attitude toward the future life with AI. In addition, students with the positive attitude were more likely to have a career hope in the area of AI.
Conclusions These findings imply that more research and education regarding the anthropomorphism of AI are necessary in elementary schools. Teachers need to help elementary school students to reflect on their previous beliefs and attitudes toward AI through authentic learning experiences with AI.
Korean Research Trends Analysis of Group Art Therapy on Children Stress
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Yoon myoung shin
Published: September 2022

Objectives The study was performed of contribution to establish and develop system of the Group Art Therapy Studies for relief and decrease of children's stress in Korea and to seek for direction as practical application reference resource for the field by means of systematic analysis focused on Korean study trends related to the Group Art Therapy.
Methods In order to perform the study, 45 master's theses and 19 academic journals; totally 64 articles which were able to browse on line from Korea Education & Research Information Service, National Assembly Library and National Museum of Korea were selected as final subjects and analyzed by frequency and percentage statistics.
Results The results of the study are as follows. First, the analysis by the basic research categorization showed that the Group Art Therapy Researches for Stressed Children seemed performed constantly from early 2000 in Korea. Second, the distribution by the clinical diagnosis of the objects for study showed that the composition of the groups was even in grades and the number of participates from 5 to 7. Third, the analysis by the contents of the studies revealed that most studies were about daily stress, and focused on the activities to enhance positive self-concept and self-esteem. Also consisting of 1 or 2 times a week total of 16 to 20 sessions and 60 to 70 minutes. Fourth, the result through the study trends analysis showed that the Ex ante and Ex post controlled experimental design method was the most commonly selected design pattern of the studies.
Conclusions This study is significance in that it suggested the use of the field of Group Art Therapy on children's stress and the direction of research in the future.
Differences in Academic Achievement, Distance Learning Experience, and Satisfaction by Level of Learning Motivation in Middle and High School Students: Focusing on Korean and Math
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Seo Bongeon , Jeong Miseon
Published: September 2022

Objectives The purpose of this study is to classify the latent groups according to the learning motivation of Korean language and mathematics of middle and high school students, and to analyze the differences in academic achievement, distance learning experiences and satisfaction in 2020 by learning motive groups.
Methods The subject of analysis is the data of 10,653 middle school students and 10,528 high school students responding to the ｢2020 National Assessment of Educational Achievement｣ of Korea Institute for Curriculum and Evaluation. For data processing, frequency analysis, factor analysis, and reliability analysis were performed using SPSS and Jamovi programs, the latent groups according to the Korean language and math learning motivation were extracted using the Mplus program, and the characteristics of each latent group were analyzed.
Results The learning motivation groups of middle and high school students were identified as upper, middle, and lower 3 groups in Korean, and upper, middle-high, middle-low, and lower 4 groups in mathematics. As a result of examining the characteristics of each group, the group with high motivation for Korean and math had good Korean and math achievement. Looking at the changes in school level, Korean learning motivation gradually increased, but Korean language achievement decreased, and math learning motivation gradually decreased, but achievement tended to increase. As a result of examining the environmental differences in distance learning experienced in 2020 by the learning motivation group, the group with high Korean and math learning motivation was found to have the least negative influence of distance learning, suggesting the possibility of a learning gap. In addition, there was a difference in satisfaction with distance learning according to the level of motivation, and lower satisfaction with feedback and communication was shown compared to other items.
Conclusions Middle and high school students' motivation for Korean and mathematics and academic achievement are closely related, suggesting the development of convergence classes between subjects. In addition, the group with high learning motivation appears to be the group that minimizes the unfavorable influence of distance learning, requiring the establishment of strategies to improve learners' learning motivation for each subject.
A Study Field Training experience of Nuclear-related Research Institutes of College Students Majoring in Nuclear Engineering
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Kim Ji Hyun , Shin Jin Myeong , Kim Woong Ki , Choi Yu Hyun
Published: September 2022

Objectives This study aims to contribute to the field Training program of correct nuclear manpower by examining the field training experience of nuclear-related research institutes of college students majoring in nuclear engineering.
Methods For this purpose, a qualitative research method was used to deeply explore the subjective experiences of the research participants, targeting two college students in the Department of Nuclear Engineering working at the K nuclear-related research institute. Participation observation, interviews, and local data collection were conducted. The collected data were derived into 3 major categories, 6 middle categories, and 17 sub-categories by performing emic coding to identify the field practice experience.
Results First, the characteristics of the field training site of the study participants were the reactor facility, measurement room, waste management space and office at the dismantling site, which can be thought of as a construction site from a spatial point of view. Second, in terms of human relations, I had a good relationship with everyone in the department. Next, the tasks of the study participants varied from administrative tasks such as planning and writing reports to measuring radioactivity concentrations in the air, and it was found that the job description and interpersonal relationships within the department were the most important in the field training program. Finally, the research participants were able to broaden their knowledge and determine the appropriateness of the work they performed through the field practice program to determine their own career direction.
Conclusions The results of this study suggest that it is necessary to help understand the field training programs of nuclear-related research institutes and to assign the roles of mentors and colleagues in the field training programs and appropriates jobs to field training students.
Exploring the Meaning of a Field-based Child Safety Management Class: Focused on Prospective Pre-Service Early Childhood Teachers
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Kyoung Yeon
Published: September 2022

Objectives This study explored the meaning of a field-based child safety management class for prospective pre-service early childhood teachers.
Methods The study period was from July to December 2021, and the participants were 61 prospective pre-service early childhood teachers who took the child safety management class at a two-year college located in S city. The study participants received a field-based child safety management class for 3 hours once a week for 15 weeks, and their reflective journals, class performance improvement evaluation sheets, end-of-semester reflection sheets, and researcher journals were collected and analyzed.
Results The results showed that the prospective pre-primary teachers experienced “connecting theory and practice through field data,” “getting ideas for child safety classes through class case analysis,” “becoming a field-oriented teacher by inviting field experts,” and “enhancing child safety class competency through field-oriented class demonstrations.”
Conclusions Through these results, it was confirmed that the field-based child safety management class for pre-service early childhood teachers had educational significance.
The Effects of Attachment Anxiety and Attachment Avoidance on Parenting Anxiety of Mothers with Children in Early Childhood: The Mediating Effects of the Perceived Marital Support and Self-compassion
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Aesun , Chung Yeoju
Published: September 2022

Objectives The purpose of this study is to examine the mediating effects of Perceived Marital Support and Self-Compassion on the effects of Attachment Anxiety and Attachment Avoidance on Parenting Anxiety.
Methods For this purpose, data were collected using the Attachment Anxiety Scale, Attachment Avoidance Scale, Parenting Anxiety Scale, Perceived spouse support scale, and self-compassion scale from 349 mothers with children in childhood. For statistical analysis of the collected data, the structural equation model verification method was used using SPSS 22.0 and Amos 22.0, and bootstrapping was performed to confirm the statistical significance of the mediating effect.
Results First, the mediating effect of perceived spouse support on the relationship between attachment anxiety, attachment avoidance, and parenting anxiety was confirmed. Second, the mediating effect of self-compassion was confirmed in the relationship between attachment anxiety and parenting anxiety. Third, in the effect of attachment anxiety and attachment avoidance on parenting anxiety, the perceived double mediating effect of spouse support and self-compassion was confirmed.
Conclusions By confirming the mediating role of Perceived Marital Support and Self-Compassion in the relationship between Attachment Anxiety, Attachment Avoidance and Parenting Anxiety, theoretical and empirical evidence was prepared for the relationship between each variable related to Parenting Anxiety, and counseling to treat Parenting Anxiety It is meaningful in that it provided information for effective therapeutic hypotheses and interventions in practice.
An Analysis of Korean Language Teachers' Pronunciation Clarity: Focusing on the Acoustic Characteristics of Vowels [i], [u], [a]
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Baek Yujin , Park Youngmin
Published: September 2022

Objectives The purpose of this study is to propose the necessity and to provide information for Korean teacher's pronunciation education by examining the pronunciation clarity of Korean teacher by analyzing Korean teacher's pronunciation of [i], [u], and [a].
Methods To this end, in this study, the characteristics of pronunciation clarity of Korean teachers were examined by collecting voice data of 82 Korean teachers, analyzing F1 and F2 of the vowels, and displaying F1 and F2 coordinates on a two-dimensional plane to calculate the Euclidean distance and the width of vowel triangle. In addition, Korean language teachers were classified by gender and career to examine whether there were differences in pronunciation clarity by group.
Results First, it was found that F1, F2 for the pronunciation of [i], [u], [a] of Korean language teachers showed a similar tendency to general Korean speakers. Second, it was found that Korean language teachers had lower pronunciation clarity than general Korean speakers. Third, it was found that female teachers clarified their pronunciation compared to male teachers. Fourth, it was found that the difference in pronunciation clarity according to the career of a Korean language teacher was not large.
Conclusions It is necessary to operate an educational program to increase the pronunciation clarity of teachers in the teacher training and teacher re-education process. In particular, pronunciation education for male teachers needs to be concentrated rather than female teachers, and education programs need to be organized so that Korean teachers with more than 10 years of experience can clearly pronounce [u].
A Case Study on the Korean Presentation Class Plan for International Student Using Gather.town: Based on Problem Based Learning
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Lee Hwa-shil , Yang Hwi-won , Jeong Chae-yun
Published: September 2022

Objectives The purpose of this study is to present a presentation class using PBL in the Gather.town environment for intermediate academic purpose learners and to propose the educational applicability of the Gather.town environment.
Methods For this purpose, the established PBL was reorganized into problem presentation-problem solving- presentation and evaluation stages to suit presentation classes in Gather.town environment, and a Gather.town map was designed, and 18 international students currently attending Korean universities and graduate schools were recruited. A total of eight classes were conducted for two weeks. A questionnaire was organized with questions about the presentation class and the class in the Gather.town environment, and a questionnaire was conducted for learners participating in the class afterward. All of the questions in the survey were answered on a Likert scale except for the last question.
Results As a result of the survey, motivation, upturn of reality, and increase in interaction were derived as the advantages of classes using Gather.town. In particular, it was confirmed that interest in the ‘presentation’ class and self-efficacy can be promoted in the process of solving problems through cooperative activities in classes to improve presentation skills.
Conclusions This study is meaningful in that it suggested the possibility of applying the Metaverse’ Korean education, a new educational environment, by designing and applying classes centered on the problem-solving process of “presentation” that international students face difficulties in using Gather.town. According to this study, it is expected that various educational attempts for international students based on the Metaverse environment will be expanded.
An Exploratory Study on the Case of Flipped Class Application to Geometry and Analysis Subjects of Mathematics Education Department
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Byun Ji Soo
Published: September 2022

Objectives This study is the result of observing and studying the changes of students and instructors in the case of applying Flipped Lessons method to mathematics lessons of the College of Education.
Methods The mathematics classes of K-University located in Gyeongsang-do was operated by flipped learning method for seven years. Through this, student’s academic achievement and lecture evaluation results were investigated, and changes in class activities and evaluation were observed.
Results The results of lecture evaluation and academic achievement of students who took mathematics classes in the Department of Mathematics Education were analyzed. Changes in the evaluation method for classes and changes in class activities over the past 7 years were also investigated. As a result, student’s academic achievement improved and there were significant changes in the lecture evaluation results. Flipped class also changed the instructor from a knowledge communicator to a learning assistant.
Conclusions The role of the College of Education as a teacher training institution is to train preparatory teachers who can teach ‘good classes’. In particular, in order to nurture teachers who can teach ‘good math classes’, it is important to experience ‘good math classes’ through flipped classes at the college.
Geography of two COVID-19 waves in Latvia
Authors:   University of Latvia, Apsite-Berina Elina , Skadins Toms ,   University of Latvia, Burgmanis Girts ,   University of Latvia, Krisjane Zaiga ,   University of Latvia, Berzins Maris ,   University of Latvia
Published: September 2022

The COVID-19 pandemic and its waves of incidence have had a significant impact on our personal and professional lives. This has led to scholarly interest in various fields, including geography. A growing body of scholarly literature is trying to understand the reasons why some places were and still are more affected than others. The aim of this study was to shed light on the geography of the Covid-19 pandemic in Latvia and explain the geographical patterns of the pandemic during its first two waves. This was done, firstly, by mapping the number of cases per 10,000 in the municipalities of Latvia; secondly, the analysis also combined that same data with a total of eleven variables, by using bivariate correlation. The results show that during the first wave, Covid-19 incidence was relatively low. However, during the second wave, there were several large clusters of municipalities with a rather high number (over 500) confirmed Covid-19 cases per 10,000 inhabitants. Results of the correlation analysis suggest that geographical patterns of COVID-19 incidence were a result of a complex set of factors, varying throughout the country. Also, the presence of large clusters of municipalities with a rather high number of cases per capita (mostly) during the second wave points to the possible impact of proximity.
Patterns of internal migration during the first year of the COVID-19 outbreak in Latvia
Authors:   University of Latvia, Krumins Janis , Berzins Maris ,   University of Latvia, Krisjane Zaiga ,   University of Latvia
Published: September 2022

The COVID-19 pandemic has profoundly changed our daily lives in ways that might have far-reaching effects on societal norms and human behaviour. However, little research has yet been devoted to the pandemic's impact on internal migration. In this article, we analyse the interconnection between COVID-19 and internal migration in Latvia. This article aims to evaluate internal migration patterns during the first year of the COVID-19 outbreak in Latvia, using available data at the municipality level. We compare migration flow statistics from the 2011–2019 period and the single year of 2020, which marked the start of the COVID-19 outbreak in Latvia. The analysis identifies similar patterns regarding internal migration activity among observed geographical units. In both time periods, the highest migration levels around Riga have been witnessed and several other large cities. Comparing these time periods highlights slightly higher migration intensity in 2020 than before COVID-19.
Does the COVID-19 pandemic help with identifying measures to reduce atmospheric pollution?
Authors:   University of Latvia, Steinberga Iveta , Truhnevics Nauris ,   University of Latvia
Published: September 2022

This article analyses the variability of gas and aerosol pollution levels in Riga (Latvia) over different periods associated with Covid-19 restrictions. The variability of atmospheric pollution levels is described from a relative point of view; the effects of meteorological parameters were assessed using Pearson's correlation factor and statistical significance. To assess whether changes were statistically relevant during the various assessment periods, the analysis was performed using the ANOVA dispersion test and the post-hoc Tukey test. Major changes have been identified in the case of gaseous atmospheric pollution.
Evaluating Pharm.D Students’ Views and Perceptions Regarding Practicing Experimental Pharmacology and Animal Handling: A Single-Site Study
Authors: Algarni Alanood S.
Published: September 2022

Animal experimentation is vital to the study of pharmacology during undergraduate studies. Regulations and most commonly, students' preferences are all factors that influence the procurement of and performance of animal experiments. In the higher educational level student’s perceptions and preferences contribute significantly to their education. Various studies indicate that using 3D models could reduce and refine animal experimentation in pharmacology teaching. Some researchers illustrate that an existing gender difference in practical classes with laboratory animals exists, indicating that a particular group may be vulnerable to lower grades if a unilateral teaching method is applied. This study seeks to determine the views and perceptions of pharmacology students to determine if a hybrid study method is better suited to help students to gain good grades and understand medical concepts associated with their field. This study aims to gauge the efficacy of such a system for use in UQU, Saudi Arabia. It illustrates the variation between male and female students regarding preference and learning capability in virtual and practical lessons. This research seeks also to determine whether a significant change in grade exists if students have an option to choose between these learning methods. Data were collected through an online questionnaire survey conducted to 121 third-year undergraduate pharmacology students from Umm Al-Qura University (UQU) college of pharmacy in Makkah, Saudi Arabia in October 2021. Undergraduate Pharm.D pharmacology students in Makkah, Saudi Arabia, have positive views and perceptions regarding handling of live animals in experimental pharmacology regardless of their gender.
Geoinformation modeling and mapping of geosystems functioning completeness
Authors: Lesnykh S.I. , Cherkashin A.K.
Published: September 2022

The completeness indicator is associated with the degree of the natural potential mani- festation and the reliable functioning of geosystems at a constantly high level. This is necessary to ensure sustainable development and effective solutions to environmental management problems. Geography and cartography can solve them using the methods of geoinformation modeling. By the example of the Slyudyansky district’s forests (Irkutsk oblast), the process of realizing the stocks completeness of the geosystem function, their reproduction under different environmental conditions is statistically studied using inventory databases. The mathematical model describes the options for the change in completeness over time, including sustainable growth and development of natural systems. A feature of the model is the existence of a bifurcation point of trends in the completeness of geosystem functions implementation. Sustainable development becomes possible only when the normative performance indicators are overflowed. According to the graphs of the time dependence of changes in forest stocks under various conditions, an assessment was made of the possibility of implementing sustainable management. To differentiate the territory according to the prerequisites for stable development, the methods of landscape-appraisal mapping were used. Geoinformation mapping of geosystem functions was carried out with the allocation of terrain areas recommended for effective nature management according to the criterion of functioning completeness.
Information support of urban planning activities in Russia
Authors: Skachkova M.E. , Gureva O.S.
Published: September 2022

Issues of digitalization and information support of urban planning activities are now becoming particularly relevant against the background of introducing the new innovation economy in all territorial governmental levels. To date, the processes of state information systems implementing for urban planning activities (ISUPA) in the regions of Russia continue, but the conceptual model of the systems in question, which can serve as a basis for developers, has not been formed. The aim of the research is to create a conceptual model of information support for urban planning in the Russian Federation by identifying directions of its transformation. The goal was achieved in the process of retrospective analysis and determining the directions of domestic ISUPA transformation. The authors carried out a retrospective critical analysis of information provision of urban planning activity in Russia (ISUP), as a result of which patterns and trends of development were identified. The directions of ISUP transformation were determined. We formulated the basic principles of construction and functioning of state information systems to ensure urban development (SISUPA). A conceptual model of modern SISUPA was constructed. A set of functional capabilities of the system is defined. The proposed conceptual model of SISUPA and the principles of its construction and operation can be used in the process of SISUPA further improvement in any region of the Russian Federation. The studies show that although digitalization in Russia in the field of urban planning goes steadily, there are problems with the implementation of measures to create a comprehensive ISUP in due time.
Auto-sustento y producción campesina en tiempos de crisis
Authors: Muñoz Calvo Francis
Published: September 2022

Este escrito forma parte de una serie de documentos elaborados por investigadoras e investigadores del Centro de Investigación en Cultura y Desarrollo de la UNED, donde a manera de ensayo se presentan análisis y reflexiones sobre el cómo diversos aspectos de nuestra realidad cotidiana se han visto afectados a partir de la aparición del COVID-19.
El COVID-19 en Costa Rica: Opciones frente a la crisis económica
Authors: Vargas Solís Luis Paulino
Published: September 2022

Artículo inicialmente publicado en el blog del autor “Soñar con los pies en la tierra” el 14de abril. Frente a la fuerte contracción que la economía experimenta, se identifican yanalizan cinco posible vías de acción, para atenuar la recesión, aliviar sus impactos socialesy crear condiciones para la recuperación futura: la redistribución equitativa de la pérdidasufrida mediante un esquema muy progresivo de impuestos y subsidios; la utilización deahorros disponibles; recurrir a diversas formas de crédito, o sea, diversas formas deendeudamiento; mediante la reasignación de recursos de usos suntuarios o prescindibleshacia usos realmente prioritarios.
COVID-19 y crisis económica: La propuesta de Carlos Alvarado: Una colcha de retazos
Authors: Vargas Solís Luis Paulino
Published: September 2022

Este artículo se publicó el 13 de mayo en el blog del autor “Soñar con los pies en la tierra”.Se analizan las propuestas para la recuperación y reactivación de la economía formuladaspor el gobierno. Se recurre a la metáfora de la colcha de retazos, para enfatizar la débilcoherencia de conjunto de la propuesta, enfatizando adicionalmente que los distintos“retazos” son de calidad disímil, o sea, algunos más relevantes desde el punto de vistaeconómico, otros de dudoso significación. Se resalta adicionalmente que la propuesta esomisa en relación con muchos detalles importantes.
Acciones comunitarias e institucionales en territorios indígenas frente a la enfermedad global – Duwé
Authors: Gutiérrez Slon Juan Antonio , Moya Aburto César , Delgado Morales Mariana , Sivas Sivas Pablo
Published: September 2022

Este escrito forma parte de una serie de documentos elaborados por investigadoras e investigadores del Centro de Investigación en Cultura y Desarrollo de la UNED, donde a manera de ensayo se presentan análisis y reflexiones sobre el cómo diversos aspectos de nuestra realidad cotidiana se han visto afectados a partir de la aparición del COVID-19.
Incidencia de la Política fiscal sobre el desarrollo territorial en Costa Rica
Authors: Hartley Ballestero Marjorie
Published: September 2022

Se analiza el aporte de los instrumentos fiscales ambientales (impuestos y cánones) utilizados en Costa Rica, para financiar actividades de conversación de la biodiversidad. Se estima la recaudación de ingresos fiscales, así como su distribución en los diferentes proyectos en favor del ambiente. Estos ingresos fiscales han contribuido con limitaciones y deficiencias en la recuperación forestal y la protección de cuerpos de agua, ubicados mayoritariamente en zonas rurales y han permitido la incorporación mujeres y personas indígenas en estas actividades económicas y de conservación. Así, la política fiscal ambiental ha contribuido medianamente con el desarrollo sostenible de estos territorios rurales, lo cual hace urgente que la política fiscal identifique nuevos instrumentos fiscales ambientales que reorienten hacia un desarrollo resiliente e inclusivo.
Methods for interpreting emergence trap specimen data for the study of ground nesting bees (Hymenoptera: Anthophila)
Authors: Portman Zachary M , Brokaw Julia , Cariveau Daniel P
Published: September 2022

Emergence traps have increasingly been used to study ground nesting
bees. They offer an advantage over other methods, such as netting or
passive traps, because they can directly measure ground nesting bees at
a landscape scale. However, emergence trapping for ground nesting bees
has limitations, including low catch rates and data that is difficult to
interpret. For example, emergence traps catch a combination of actively
nesting bees, newly emerging bees from nests provisioned the previous
year, overwintering bees, and incidental bees, such as
non-ground-nesting species or bees that were simply sleeping on
vegetation. Further, a single emergence trap can capture many specimens
from a single nest due to the presence of workers, newly emerging
reproductives (gynes), or multiple siblings from a nest provisioned the
previous year. Due to these factors, a thorough knowledge of the life
history of bee species collected is necessary to accurately filter and
interpret the data. Here, we provide methods to determine whether bee
specimens caught from emergence traps came from nests. Using a
combination of trap data, life-history characters, and estimates of bee
age, we classify bees as newly emerging, active nests, or incidentally
caught. This will allow researchers to reduce the risk of spurious
inferences that may over- or under-estimate bee nesting. Many areas of
future research remain, particularly studies on the efficacy of
emergence traps for ground-nesting bee research as well as a glaring
need to better document the life-history of many bee species.   Abstract
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Anticancer and apoptotic effects of a polysaccharide extract isolated from Lactarius chrysorrheus Fr. in HepG2 and PANC-1 cell lines
Authors: Mutlu Dogukan , Cakir Cansel , Ozturk Mehmet , Arslan Sevki
Published: September 2022

Mushrooms are widely used in many cultures for nutritional and health benefits. The Lactarius species is found in the Aegean region of Turkey. Lactarius chrysorrheus Fr. is a wild mushroom that contains a milky juice. In this study, we investigated the in vitro cytotoxic potential and apoptotic effect of the polysaccharide extract prepared from L. chrysorrheus by water extraction and alcohol precipitation using the tetrazolium MTT dye assay, annexin V staining, wound healing and colony formation, and qRT-PCR. The molecular weights of three peaks observed in HPLC chromatograms were calculated as 1869.9, 3043.92 and 16821.47 Da. The extract exhibited cytotoxic activity at 72 h, with an IC50 value of 296.42 ?g/mL in HepG2 and 444.43 ?g/mL in PANC-1 cells; the extract that was tested on the normal HEK293 cell line exhibited no cytotoxicity. Further, L. chrysorrheus upregulated the expression of CASPASE 3 and CASPASE 9 while downregulating B-cell lymphoma 2 (BCL-2) and B-cell lymphoma-extra large (Bcl-xL) genes, and inhibited cell migration and colony formation in HepG2 and PANC-1 cells. This study provides new insight into the use of the polysaccharide from L. chrysorrheus in the development of novel anticancer agents.
Global Research on Tinospora cordifolia (Medicinal Plant) with Special Reference to India: A Scientometric Assessment Publications Output during 2001-2016
Authors: Gupta Ritu
Published: September 2022

The paper examines 865 global and 747 Indian publications on Tinospora cordifolia research, as indexed in international Scopus database during 2001-2016. Indian research output experienced an annual average growth rate of 11.85%, global publication share of 86.36%, international collaborative publication share of 7.50% and qualitative citation impact averaged to 15.15 citations per paper. Pharmacology, toxicology & pharmaceutics, among subjects, accounted for the highest publications share (57.30%) in Indian output, followed by medicine (33.60%), biochemistry, genetics & molecular biology (23.83%), agricultural & biological sciences (16.06%), chemistry (5.62%), immunology & microbiology (4.55%), environmental science (4.28%) and veterinary science (2.95%) during 2001-2016.The top 15 most productive Indian research organizations and the authors collectively contributed 24.23% and 14.73% respectively as their Indian publication share and 42.70% and 16.59% respectively as their Indian citation share during 2001-2016. Among the total Indian journal output with 98.39% Indian share, the top 20 journals contributed 31.32% share to the Indian journal output during 2001-2016. Of the total Tinospora cordifolia Indian research output, the top 18 highly cited publications registered citations from 104 to 1014 and they together received 4110 citations, with 228.33 citations per paper. These 18highly cited papers involved the participation of 72 authors and 33 organizations and were published in 9 journals.
A Review on Pharmacological Aspects of Achyranthes Aspera
Authors: Singh Navjeet
Published: September 2022

Plant resources constitute an important natural wealth of Country. They play a significant role in providing primary health care service to rural people in addition large number of economic products. In contain secondary metabolites like alkaloids, glycosides, tannins, terpenoid, flavonoid, phenol, volatiles oils and many more compounds with serve as important therapeutic agents. Achyranthes aspera L(Amaranthaceae) is an important medicinal herb found as a weed throughout India. Achyranthes aspera is preninal herbbelonging to family Amaranthaceae. Wide numbers of phytochemical constituents have been isolated from the plant which possesses activities like antiperiodic, diuretic, purgative, laxative antiasthmatic, hepatoportective, anti-allergic and various other important medicinal properties. Traditionally, the plant is used in pneumonia, diarrhea, dysentery, asthma, cough, dropsy, ulcers, piles, rheumatism, scabies snake bite and other skin diseases. It contains the phytochemicals like oleanolic acid, Saponin A and saponin B.
In Vitro Nephroprotective Activity of Selected Herbal Plants on Vero Cell Line
Authors: Movaliya Vinit R
Published: September 2022

Nephrotoxicity is common side effect of many drugs like anticancer, aminoglycoside antibiotic and radioactive compounds. In allopathy there is no effective treatment for the cure of kidney diseases. Aerva javanica, Ocimum basilicum and Kalanchoe pinnata are nephroprotective plant to treat various kidney diseases. This experiment was aimed to evaluate nephroprotective activity of above plants on Vero cell line. Optimization of dose of Cisplatin was done using MTT assay against Vero cell line upto 50% of cytotoxicity. Optimized concentration of Cisplatin was further used for the treatment of different extracts of Aerva javanica, Ocimum basilicum and Kalanchoe pinnata against Vero cell line individually. Full factorial design was performed to develop eight different combinations of extracts of selected plants. They were evaluated using MTT cell viability assay. The 50 μg/ml dose of Cisplatin was found to produce upto 50% of cell cytotoxicity. In the treatment model, % inhibition of Aerva javanica and Kalanchoe pinnata plant extracts at dose level 250 and 500 μg/ml were found more effective than Ocimum basilicum when compared with Cisplatin. In the treatment model, % inhibition of combination formula no. 3, 4 and 7 were found significant effective than other combinations with compared to Cisplatin. These experiments showed the plant Aerva javanica was most active than other two selected plants by using Cisplatin against Vero cell line. The combination of plants Aerva javanica and Kalanchoe pinnate were shows better effect at dose level 500 and 100 μg/ml compared to other combinations.
Natural Product Chemistry and Computer Aided Drug Design an Approach to Drug Discovery: A Review Article
Authors: Ugariogu Sylvester Nnaemeka
Published: September 2022

Natural products have been an inherent part of sustaining acculturation because of their medicinal properties. Past discoveries of bioactive natural products have relied on serendipity and accidental experience, and these compounds serve as inspiration for the generation of analogs with desired physicochemical properties. Bioactive natural products with therapeutic potential are abundantly available in nature and some of them are beyond exploration by conventional methods. However there has been a great breakthrough in the study of computer aided drug design (CADD) as many unfruitful lab researches have been averted and money, time and energies saved through CADD. Computer-aided drug design is a stimulating, arousing and manifold discipline where various aspects of applied and basic research integrate and induce each other. The empirical basis of CADD involves quantum mechanics and molecular modeling studies like structure based drug design; ligand-based drug design; database searching and binding affinity based on the knowledge of a biological target. In this present review we present the areas where natural product chemistry and CADD tools support drug discovery processes.
Volatile Composition and Biological Activities of Tagetes (Marigold): An Overview
Authors: Joshi Rakesh Kumar
Published: September 2022

Tagetes commonly known as wild marigold is a plant belonging to family Asteraceae. Tagetes minuta L., commonly known as African marigold, is reputed as a source of ‘Tagetes oil’ of trade that finds an extensive use in food, flavoring, pharmaceutical, perfumery and cosmetic industry. The plant is valued for its essential oil, which is present almost in every part of the plant with little percentage in the stem and roots. The plant is native to South America and has been introduced to many countries since the time of Spanish conquest. Many species of this genus, such as T. minuta, T. erecta, T. patula, and T. tenuifolia, are cultivated as ornamental plants and studied for their medicinal properties based on the basis of their use in folk medicine. Different parts of the Tagetes species are used as remedies to treat various health problems, including dental, stomach, intestinal, emotional, and nervous disorders and muscular pain, across the world. Furthermore, these plants are studied in the field of agriculture for their fungicidal, bactericidal, and insecticidal activities. The plant occurs in temperate forests and mountain regions of the world. Himachal Pradesh, Uttrakhand and Jammu & Kashmir are the main sources of “Tagetes oil” in India where it occurs at an altitude of 1000 to 2500m AMSL. The major constituents (90-95%) of Tagetes minuta essential oil are Z-ß-ocimene, limonene (hydrocarbons) and acyclic unsaturated monoterpenes ketones, dihydrotagetone, tagetones (E, Z) and ocimenones (E, Z). The plant possess pharmacological, phytotoxic effect, antibacterial and antifungal effect, insecticidal properties, nematicidal properties, antiviral and antimicrobial activity and also find use in perfume and flavour industry. Its oil has a great demand, so the species holds a lot of potential for undertaking its large-scale cultivation.
Assessment of Knowledge, Attitude and Practice of Health Workers towards Safe Abortion Care Services at Asella Referral and Teaching Hospital, Central Ethiopia
Authors: Kalayu Ismael
Published: September 2022

According to World Health Organization safe abortion care include services that are provided by trained health workers, supported by policies, regulations and a functional health infrastructure, including equipment and supplies. Provision of safe abortion to the extent of the law, emergency treatment of abortion complications, provision of post abortion contraception, education and other lifesaving care services are inadequately given the presence of legal, social, cultural and economic impediments. Most of health care providers are not aware of the fact that termination of pregnancy is permitted under certain conditions leading to ranges of inappropriate attitudinal frameworks or mindset implying a major barrier to give the service. The aim of this research was to assess knowledge, attitude and practice of health workers towards safe abortion service at Asella Referral and teaching hospital, Asella town, Arsi Zone, Oromia region, Ethiopia. An institutional based descriptive cross-sectional study design was used to assess knowledge, attitude and practice of health workers towards safe abortion service at Asella Referral and teaching hospital from January 2017 to May 2017. Systematic random sampling technique was used to select 185 health workers. SPSS version 20 statistical software was employed for data entry and analysis. Of the selected subjects, 99(53.5%) were in the age group of 25-29 years with the mean age of 28.45 ± 3.7 years. In this study, 150(81.1%), 126(68.1%) and 127(68.1%) of health workers had good knowledge, positive attitude and good practice towards safe abortion care .Despite the present law is less restrictive and it was found a general positive KAP of health practitioners matching with the abortion law, some areas like antiabortion attitudes, lack of training and service offering facilities, confidentiality and consequences of misinterpreting the law might be still potentially problematic.
Menstrual Hygiene: A Salubrious Approach to Curb Gynecological Problems
Authors: Rawat Geeta
Published: September 2022

Background: Reproductive tract infections (RTIs) are associated with poor menstrual hygiene management (MHM) practices and it lead to gynecological problems. We aimed to determine which factors are responsible poor menstrual hygiene practices and were associated with common infections of the lower reproductive tract. Importance: Proper management of menstrual hygiene is taken for granted in many countries, including India and mainly in the rural population as inadequate menstrual hygiene is a major problem for females which adversely affects the health and development of females. Objective: The aim of this article is to know the various factors responsible for poor menstrual hygiene which is giving rise to various infections in females and list various type of infection which is occurring due to bad menstrual practices. Conclusion: They are various factors affecting menstrual hygiene management includes lack of knowledge and awareness, ignorance and embracement; teasing by peer’s poor familial support, lack of cultural acceptance of alternative menstrual products; limited resources to purchase pads, inadequate water and sanitation facilities. People should be able to define what is meant by “adequate menstrual hygiene management,” identify the challenges to adequate menstrual hygiene management, and describe some of the intervention strategies that have been proposed to improve menstrual hygiene management for females. The results of our review add to growing number of studies which demonstrate a strong and consistent association between poor menstrual hygiene practices and higher prevalence of lower RTIs and gynecological cancers.
FINANCIAL DISTRESS, DIVIDEND POLICY, RGEC AND EARNING PER SHARE
Authors: Widagdo Bambang , Sa'diyah Chalimatuz
Published: September 2022

This study aims to examine and analyze the effect of Financial Distress, Dividend Policy and RGECon Firm Value with EPS as the intervening variable. This research is explanatory in nature and employs a quantitative descriptive method. The data utilized was gathered from the annual financial reports of commercial banks in Indonesia from 2012 to 2018, with a sample size of 23 bank. The collected data was then analyzed using SEM (Structural Equation Model) and the PLS3 Program. According to the findings of this study, Financial Distress has no influence on firm value or Earningsper share (EPS). The dividend policy and the RGEC have a major impact on EPS. Firm Value is significantly influenced by RGEC and EPS. The connection between Dividend Policy and RGECon Firm Value can be mediated through EPS. Meanwhile, the EPS variable cannot mediate the influence of Financial Distress on Firm Value.
TECHNOPRENEURSHIP ON MARKET PENETRATION AND PRODUCT DEVELOPMENT IN MICRO AND SMALL ENTERPRISES
Authors: Rusliati Ellen , Affandi Azhar , Mulyaningrum Mulyaningrum , Alghifari Erik
Published: September 2022

This study aims at identifying the factors that affect the application of technopreneurship on micro and small enterprises in Majalengka Regency. The factors include market penetration, new product development, pricing, product quality, innovation, promotion, distribution, and network and collaboration. Employing accidental sampling, 111 entrepreneurs were sampled to take a questionnaire from which the results were analyzed using descriptive and verification statistics. The research model analyzed using Partial Least Square method and assisted by Smart PLS3 software. It was found that the results of the analysis on technopreneurship indicated that new product development, market penetration, promotion, and network and collaboration had been done adequately. Meanwhile, pricing, product quality, innovation, and distribution had been done well. Technopreneurship has significant effect on innovation, product quality, promotion, marketing, market penetration, and product development strategy.
APLIKASI DRONE-UAV UNTUK SURVEY DAN PEMETAAN MENGGUNAKAN COPTER PADA PERKEBUNAN KELAPA SAWIT (Studi Kasus : Bahruny Group, PT. Satya Agung, Lhoksemawe, Aceh)
Authors: Ardiansyah Dede
Published: September 2022

Drone is a UAV vehicle which is currently widely used in various activities, one of which is for aerial photography (photogrammetry). The concept of efficiency is the main goal of using this drone, which is to produce detailed and up-to-date aerial photo images with adjustable area coverage, relatively short time, affordable costs and minimal personnel required. The output is an orthophoto image that already has coordinates and can be used as primary data for convenience in the tree counting process so that tree populations in blocks based on design and area statements can be known in detail and accountably. The aerial mapping process using a copter unmanned vehicle with a height of 80-meters above ground level at an image resolution of 2.23 cm/pixel produces 3,795 photos with side overlap and front overlap photos of 70% and 80% with an area covering 2.72 km2 or 272 ha. The results of the calculation of oil palm trees as many as 3,147 pkk with a statement area of 29.08 ha in Block M06 and obtained an SpH of 108 pkk which is smaller than the ideal SpH ranging from 135-143 pkk/ha so that there is a need for compaction activities or plant fulfillment in the block.