bluuebunny/crossref_metadata_2025 huggingface dataset:
“Your Life Turns Upside Down”: A Qualitative Study of the Experiences of Parents with Children Diagnosed with Phelan-McDermid Syndrome
Authors: García-Bravo Cristina , Palacios-Ceña Domingo , Huertas-Hoyas Elisabet , Pérez-Corrales Jorge , Serrada-Tejeda Sergio , Pérez-de-Heredia-Torres Marta , Gueita-Rodríguez Javier , Martínez-Piédrola Rosa Mª
Published: December 2022

(1) Background: Parents of children with rare diseases experience great uncertainty and employ different strategies to care for their children and cope with the disease. The purpose of the present study was to describe the perspective of parents with children with Phelan McDermid Syndrome (PMS). (2) Methods: A non-probabilistic purposeful sampling was used to perform this qualitative descriptive study. Thirty-two parents with children with PMS were interviewed. In-depth interviews and research field notes were analyzed using an inductive thematic analysis. (3) Results: Four themes emerged from the data. “Understanding and accepting the disease” described how parents experienced their child’s diagnosis and the lack of information. The second theme, called “Living day by day”, highlighted the daily difficulties faced when caring for a child with PMS. The third theme, “Expectations versus reality”, was based on the parents’ expectations of parenthood and the reality they face. Expectations for the future are also included. Finally, “Pain and happiness” describes how parents alternate feelings of distress and suffering but also joy with what they learn from these experiences. (4) Conclusions: Health professionals can use these results to support parents.
Recent Progress in the Theoretical Studies of the Noncovalent Interactions of Supramolecular Complexes with Polyhalides and Halometalates
Authors: Novikov Alexander S.
Published: December 2022

Despite the fact that first polyhalides and halometalates have been discovered decades ago, this subject of chemical science has been progressing, and many supramolecular associates with these compounds exhibiting promising properties were reported. In this mini-review, I would like to highlight recent progress in theoretical studies of noncovalent interactions in supramolecular complexes with polyhalides and halometalates from our research group.
Machine Learning Models and Intra-Daily Market Information for the Prediction of Italian Electricity Prices
Authors: Golia Silvia , Grossi Luigi , Pelagatti Matteo
Published: December 2022

In this paper we assess how intra-day electricity prices can improve the prediction of zonal day-ahead wholesale electricity prices in Italy. We consider linear autoregressive models with exogenous variables (ARX) with and without interactions among predictors, and non-parametric models taken from the machine learning literature. In particular, we implement Random Forests and support vector machines, which should automatically capture the relevant interactions among predictors. Given the large number of predictors, ARX models are also estimated using LASSO regularization, which improves predictions when regressors are many and selects the important variables. In addition to zonal intra-day prices, among the predictors we include also the official demand forecasts and wind generation expectations. Our results show that the prediction performance of the simple ARX model is mostly superior to those of machine learning models. The analysis of the relevance of exogenous variables, using variable importance measures, reveals that intra-day market information successfully contributes to the forecasting performance, although the impact differs among the estimated models.
Neutral-Type and Mixed Delays in Fractional-Order Neural Networks: Asymptotic Stability Analysis
Authors: Popa Călin-Adrian
Published: December 2022

The lack of a conventional Lyapunov theory for fractional-order (FO) systems makes it difficult to study the dynamics of fractional-order neural networks (FONNs). Instead, the existing literature derives necessary conditions for various dynamic properties of FONNs using Halanay-type lemmas. However, when these lemmas are used, the results are frequently more conservative than those produced for integer-order neural networks (NNs). In order to provide sufficient criteria that are less conservative than those found in other research, a novel application of the Halanay-type lemma is made within this study. Thus, for extremely general FONNs containing neutral-type, time-varying, and distributed delays, sufficient conditions presented by way of linear matrix inequalities (LMIs) and algebraic inequalities are achieved. For the FO scenario, a model this broad and including so many different kinds of delays is developed for the first time. Additionally, a novel form of Lyapunov-like function is built, which results in less stringent algebraic inequalities. One of the first times in the setting of FONNs, the free-weighting matrix method is also used to further lower the conservativeness of the obtained conditions. Based on different Lyapunov-type functions, three theorems are developed regarding the asymptotic stability of the proposed networks. Three numerical simulations are used to demonstrate the theoretical developments.
Growth Factor Binding Peptides in Poly (Ethylene Glycol) Diacrylate (PEGDA)-Based Hydrogels for an Improved Healing Response of Human Dermal Fibroblasts
Authors: Clevenger Abigail J. , Jimenez-Vergara Andrea C. , Tsai Erin H. , de Barros Righes Gabriel , Díaz-Lasprilla Ana M. , Ramírez-Caballero Gustavo E. , Munoz-Pinto Dany J.
Published: December 2022

Growth factors (GF) are critical cytokines in wound healing. However, the direct delivery of these biochemical cues into a wound site significantly increases the cost of wound dressings and can lead to a strong immunological response due to the introduction of a foreign source of GFs. To overcome this challenge, we designed a poly(ethylene glycol) diacrylate (PEGDA) hydrogel with the potential capacity to sequester autologous GFs directly from the wound site. We demonstrated that synthetic peptide sequences covalently tethered to PEGDA hydrogels physically retained human transforming growth factor beta 1 (hTGFβ1) and human vascular endothelial growth factor (hVEGF) at 3.2 and 0.6 ng/mm2, respectively. In addition, we demonstrated that retained hTGFβ1 and hVEGF enhanced human dermal fibroblasts (HDFa) average cell surface area and proliferation, respectively, and that exposure to both GFs resulted in up to 1.9-fold higher fraction of area covered relative to the control. After five days in culture, relative to the control surface, non-covalently bound hTGFβ1 significantly increased the expression of collagen type I and hTGFβ1 and downregulated vimentin and matrix metalloproteinase 1 expression. Cumulatively, the response of HDFa to hTGFβ1 aligns well with the expected response of fibroblasts during the early stages of wound healing.
Perspectives of Aboriginal People Affected by Cancer on the Need for an Aboriginal Navigator in Cancer Treatment and Support: A Qualitative Study
Authors: Thackrah Rosalie D. , Papertalk Lenelle P. , Taylor Karen , Taylor Emma V. , Greville Heath , Pilkington Leanne G. , Thompson Sandra C.
Published: December 2022

Aboriginal and Torres Strait Islander Australians suffer higher rates of cancer and poorer outcomes than the wider population. These disparities are exacerbated by rurality and remoteness due to reduced access and limited engagement with health services. This study explored the cancer journeys of Aboriginal patients and carers, and their views on the establishment of an Aboriginal Patient Navigator role within the Western Australian healthcare system to support cancer patients and their families. Sixteen Aboriginal participants were interviewed either face to face, by telephone, or via video conferencing platforms. The interviews were then recorded, transcribed, and thematically analyzed using standard qualitative techniques. Close consultation within the research team enhanced the rigour and robustness of the study findings. Patients and carers identified many gaps in cancer service delivery that made their experiences stressful and unnecessarily complex. Challenges included a lack of stable accommodation, financial burdens, constant travel, being “off-Country”, and miscommunication with health professionals. Key sources of support and strength were the centrality of family and ongoing cultural connectedness. All participants were supportive of an Aboriginal Patient Navigator role that could address shortfalls in cancer service delivery, especially for patients from rural and remote communities. A culturally safe model of support has the potential to increase access, reduce anxiety and improve health outcomes.
Generating Novel Tomato Germplasm Using the Ancestral Wild Relative of Solanum pimpinellifolium
Authors: Li Wenzhen , Li Yuhang , Liang Yingnuan , Ni Linlin , Huang Huofeng , Wei Yushuang , Wang Mingcui , Zhang Lida , Zhao Lingxia
Published: December 2022

To create novel tomato (Solanum lycopersicum) germplasm, a wild tomato relative, S. pimpinellifolium (a red-fruited LA1585 accession), was used as the male parent to cross with the yellow-fruited tomato mutant, e9292 (S. lycopersicum). Forty-four morphological characteristics were examined in the present study; 22 S. pimpinellifolium (LA1585) traits and six S. lycopersicum (e9292) traits were dominant in the hybrids (first generation, F1); 10 were intermediate types, and the remaining six resulted in a nonmorphological difference. Ten representative lines were chosen from 1338 line of the second generation of the hybrid (e9292 × LA1585). The ascorbic acid content was higher in three F2 hybrids than in LA1585, which had higher parental levels, as well as the lycopene content in two of the hybrid lines. The fructose and glucose contents were higher in five F2 hybrids compared to e9292, and the sugar/acid value was higher in three hybrid lines. The broad-sense heritability values ranged from 75.06% for total soluble solids to 99.92% for ascorbic acid, and the average value was 92.66% for 15 quality traits. When seedlings were exposed to NaCl and mannitol, the tolerance of high salt concentrations and drought was enhanced in two hybrid lines (F2-266 and F2-299) compared with else tomatoes (e9292, LA1585, F1 hybrids, and F2-332). We created novel tomato germplasm resources with horticulturally desirable quality traits and abiotic stress tolerance, thus offering a methodology for novel tomato germplasm creation and evaluation.
Current Understanding on the Role of Lipids in Macrophages and Associated Diseases
Authors: Florance Ida , Ramasubbu Seenivasan
Published: December 2022

Lipid metabolism is the major intracellular mechanism driving a variety of cellular functions such as energy storage, hormone regulation and cell division. Lipids, being a primary component of the cell membrane, play a pivotal role in the survival of macrophages. Lipids are crucial for a variety of macrophage functions including phagocytosis, energy balance and ageing. However, functions of lipids in macrophages vary based on the site the macrophages are residing at. Lipid-loaded macrophages have recently been emerging as a hallmark for several diseases. This review discusses the significance of lipids in adipose tissue macrophages, tumor-associated macrophages, microglia and peritoneal macrophages. Accumulation of macrophages with impaired lipid metabolism is often characteristically observed in several metabolic disorders. Stress signals differentially regulate lipid metabolism. While conditions such as hypoxia result in accumulation of lipids in macrophages, stress signals such as nutrient deprivation initiate lipolysis and clearance of lipids. Understanding the biology of lipid accumulation in macrophages requires the development of potentially active modulators of lipid metabolism.
Synthesis, Structure and Mg2+ Ionic Conductivity of Isopropylamine Magnesium Borohydride
Authors: Kristensen Lasse , Amdisen Mads , Andersen Mie , Jensen Torben
Published: December 2022

The discovery of new inorganic magnesium electrolytes may act as a foundation for the rational design of novel types of solid-state batteries. Here we investigated a new type of organic-inorganic metal hydride, isopropylamine magnesium borohydride, Mg(BH4)2∙(CH3)2CHNH2, with hydrophobic domains in the solid state, which appear to promote fast Mg2+ ionic conductivity. A new synthetic strategy was designed by combination of solvent-based methods and mechanochemistry. The orthorhombic structure of Mg(BH4)2∙(CH3)2CHNH2 was solved ab initio by the Rietveld refinement of synchrotron X-ray powder diffraction data and density functional theory (DFT) structural optimization in space group I212121 (unit cell, a = 9.8019(1) Å, b = 12.1799(2) Å and c = 17.3386(2) Å). The DFT calculations reveal that the three-dimensional structure may be stabilized by weak dispersive interactions between apolar moieties and that these may be disordered. Nanoparticles and heat treatment (at T > 56 °C) produce a highly conductive composite, σ(Mg2+) = 2.86 × 10−7, and 2.85 × 10−5 S cm−1 at −10 and 40 °C, respectively, with a low activation energy, Ea = 0.65 eV. Nanoparticles stabilize the partially eutectic molten state and prevent recrystallization even at low temperatures and provide a high mechanical stability of the composite.
Evaluation of Rearing Factors Affecting Clanis bilineata tsingtauica Mell Larvae Fed by Susceptible Soybean Variety NN89-29 in Spring and Autumn Sowing
Authors: Liu Xiaofeng , Yan Yulu , Liu Nan , Xu Yufei , Jiang Huiyan , Ye Zhihao , Wang Hao , Gai Junyi , Xing Guangnan
Published: December 2022

Clanis bilineata tsingtauica Mell is a nutritious edible insect. In the present study, soybean variety NN89-29 susceptible to leaf-feeding insects was used as the experiment material to evaluate the rearing factors affecting the production of C. bilineata tsingtauica in spring and autumn sowing. We artificially inoculated C. bilineata tsingtauica eggs to soybean plants, and the relevant indexes of larvae and soybean plants were recorded. The main results from spring sowing were as follows: (1) Larval number, single larval weight and plot-larval weight were all higher in the V6 stage (sixth trifoliolate) than those in the R3 stage (beginning pod) of inoculated eggs. (2) Larval number, single larval weight and plot-larval weight significantly decreased under higher planting density. Meanwhile, the soybean plant height and internode length increased, while the main stem node number of soybean decreased under higher planting density. (3) Single larval weight and plot-larval weight were not significantly affected by different numbers of eggs inoculated, but the larval number was significantly affected. Under autumn sowing conditions: (1) The larvae production and soybean plant growth were not significantly affected by covering the top of the net house with plastic film to isolate rainwater. (2) More eggs inoculated were associated with higher plot-larval weight. Conversely, fewer eggs inoculated resulted in a higher proportion of single larvae weight more than or equal to 6 g (≥6 g). Compared to spring sowing, the low biomass of autumn-sown soybean plants did not provide sufficient food for C. bilineata tsingtauica growth, and competition for food resulted in lower larval number, single larval weight and plot-larval weight.
Multi-Degree-of-Freedom for Underwater Optical Wireless Communication with Improved Transmission Performance
Authors: Liu Anliang , Zhang Ruolin , Lin Bin , Yin Hongxi
Published: December 2022

Underwater optical wireless communication (UOWC) has great potential to provide high-speed and intensive communications over short ranges underwater. However, the mobility of the UOWC system is limited by the strict alignment requirements between the transceivers. In this paper, a multi-degree-of-freedom (MDOF) UOWC system with high flexibility and improved transmission performance is proposed and experimentally demonstrated based on the off-the-shelf light-emitting diode (LED) source. A hardware pre-equalization circuit is employed at the transmitter to extend the modulation bandwidth from 5.03 MHz to 50 MHz. At the receiving end, a Fresnel lens array is constructed to achieve efficient convergence of multiple incident optical signals from different directions. To improve the underwater signal transmission quality, we designed an additional digital signal recovery module after the trans-impedance amplifier. Finally, an experimental system is established with a 460 nm blue LED. The communication reliability of the system is verified by the measurement of the eye diagram and the bit error rate of the recovered signal at the receiving end. The experimental results show that optical signals from three different incident directions with a maximum data rate of 100 Mbps are reliably transmitted over a 1.2-m-long water tank using the non-return-to-zero on-off-keying modulation format.
Does Forest Soil Fungal Community Respond to Short-Term Simulated Nitrogen Deposition in Different Forests in Eastern China?
Authors: Liu Zhenyue , Xu Gexi , Tian Di , Lin Quanhong , Ma Suhui , Xing Aijun , Xu Longchao , Shen Haihua , Ji Chengjun , Zheng Chengyang , Wang Xiangping , Fang Jingyun
Published: December 2022

Nitrogen (N) deposition has changed plants and soil microbes remarkably, which deeply alters the structures and functions of terrestrial ecosystems. However, how forest fungal diversity, community compositions, and their potential functions respond to N deposition is still lacking in exploration at a large scale. In this study, we conducted a short-term (4–5 years) experiment of artificial N addition to simulated N deposition in five typical forest ecosystems across eastern China, which includes tropical montane rainforest, subtropical evergreen broadleaved forest, temperate deciduous broadleaved forest, temperate broadleaved and conifer mixed forest, and boreal forest along a latitudinal gradient from tropical to cold temperature zones. Fungal compositions were identified using high-throughput sequencing at the topsoil layer. The results showed that fungal diversity and fungal community compositions among forests varied apparently for both unfertilized and fertilized soils. Generally, soil fungal diversity, communities, and their potential functions responded sluggishly to short-term N addition, whereas the fungal Shannon index was increased in the tropical forest. In addition, environmental heterogeneity explained most of the variation among fungal communities along the latitudinal gradient. Specifically, soil C: N ratio and soil water content were the most important factors driving fungal diversity, whereas mean annual temperature and microbial nutrient limitation mainly shaped fungal community structure and functional compositions. Topsoil fungal communities in eastern forest ecosystems in China were more sensitive to environmental heterogeneity rather than short-term N addition. Our study further emphasized the importance of simultaneously evaluating soil fungal communities in different forest types in response to atmospheric N deposition.
Inoculation of Indigenous Arbuscular Mycorrhizal Fungi as a Strategy for the Recovery of Long-Term Heavy Metal-Contaminated Soils in a Mine-Spill Area
Authors: Silva-Castro Gloria Andrea , Cano Custodia , Moreno-Morillas Silvia , Bago Alberto , García-Romera Inmaculada
Published: December 2022

Symbiotic associations with arbuscular mycorrhizal fungi (AMF) offer an effective indirect mechanism to reduce heavy metal (HM) stress; however, it is still not clear which AMF species are more efficient as bioremediating agents. We selected different species of AMF: Rhizoglomus custos (Custos); Rhizoglomus sp. (Aznalcollar); and Rhizophagus irregularis (Intraradices), in order to study their inoculation in wheat grown in two soils contaminated with two levels of HMs; we tested the phytoprotection potential of the different AMF symbioses, as well as the physiological responses of the plants to HM stress. Plants inoculated with indigenous Aznalcollar fungus exhibited higher levels of accumulation, mainly in the shoots of most of the HM analyzed in heavily contaminated soil. However, the plants inoculated with the non-indigenous Custos and Intraradices showed depletion of some of the HM. In the less-contaminated soil, the Custos and Intraradices fungi exhibited the greatest bioaccumulation capacity. Interestingly, soil enzymatic activity and the enzymatic antioxidant systems of the plant increased in all AMF treatments tested in the soils with both degrees of contamination. Our results highlight the different AMF strategies with similar effectiveness, whereby Aznalcollar improves phytoremediation, while both Custos and Intraradices enhance the bioprotection of wheat in HM-contaminated environments.
Line-Structured Light Fillet Weld Positioning Method to Overcome Weld Instability Due to High Specular Reflection
Authors: Wang Jun , Zhang Xuwei , Liu Jiaen , Shi Yuanyuan , Huang Yizhe
Published: December 2022

Fillet welds of highly reflective materials are common in industrial production. It is a great challenge to accurately locate the fillet welds of highly reflective materials. Therefore, this paper proposes a fillet weld identification and location method that can overcome the negative effects of high reflectivity. The proposed method is based on improving the semantic segmentation performance of the DeeplabV3+ network for structural light and reflective noise, and, with MobilnetV2, replaces the main trunk network to improve the detection efficiency of the model. To solve the problem of the irregular and discontinuous shapes of the structural light skeleton extracted by traditional methods, an improved closing operation using dilation in a combined Zhang-suen algorithm was proposed for structural light skeleton extraction. Then, a three-dimensional reconstruction as a mathematical model of the system was established to obtain the coordinates of the weld feature points and the welding-torch angle. Finally, many experiments on highly reflective stainless steel fillet welds were carried out. The experimental results show that the average detection errors of the system in the Y-axis and Z-axis are 0.3347 mm and 0.3135 mm, respectively, and the average detection error of the welding torch angle is 0.1836° in the test of a stainless steel irregular fillet weld. The method is robust, universal, and accurate for highly reflective irregular fillet welds.
Optimal Demodulation Band Extraction Method for Bearing Faults Diagnosis Based on Weighted Geometric Cyclic Relative Entropy
Authors: Wang Chunlei , Gao Ang , Xuan Jianping
Published: December 2022

Optimal demodulation band extraction is a significant step in rolling bearing fault analysis. However, existing methods, primarily based on global indexes and neglecting negative local outliers, cannot identify compound faults in intense noise environments. To address this problem, a novel demodulation band extraction method based on weighted geometric cyclic relative entropy (WGCRE) is proposed. WGCRE is defined on the cyclic sub-bands model of the logarithmic envelope spectrum (LES) to fully consider the bearing characteristic frequency of pseudo-cyclostationarity. In detail, local and global thresholds are separately set by the white noise parameter and harmonic-to-noise ratio to exclude the exogenous noise outliers. On this basis, the WGCRE is defined as a geometrically weighted index of several different fault types to avoid harmonic interference and improve the identification of composite faults. WGCRE–gram, similar to fast kurtogram (FK), is then constructed by replacing kurtosis with WGCRE to extract the optimal demodulation band. Compared with FK and another LES-based method, logarithmic-cycligram, the proposed method is more robust for accurately identifying single and compound faults under external noise. The effectiveness of this method is verified through simulations and actual tests. Simulation experiments of different kinds and intensities of exogenous noise interference preliminarily determine the superior robustness of WGCRE in the face of solid noise. The inner ring, outer ring, and composite fault experiments further confirmed the robust adaptability of WGCRE in the face of complex working conditions.
A Review of Energy and Sustainability KPI-Based Monitoring and Control Methodologies on WWTPs
Authors: de Matos Bárbara , Salles Rodrigo , Mendes Jérôme , Gouveia Joana R. , Baptista António J. , Moura Pedro
Published: December 2022

Humanity faces serious problems related to water supply, which will be aggravated by population growth. The water used in human activities must be treated to make it available again without posing risks to human health and the environment. In this context, Wastewater Treatment Plants (WWTPs) have gained importance. The treatment process in WWTPs is complex, consisting of several stages, which consume considerable amounts of resources, mainly electrical energy. Minimizing such energy consumption while satisfying quality and environmental requirements is essential, but it is a challenging task due to the complexity of the processes carried out in WWTPs. One form of evaluating the performance of WWTPs is through the well-known Key Performance Indicators (KPIs). The KPIs are numerical indicators of process performance, being a simple and common way to assess the efficiency and eco-efficiency of a process. By applying KPIs to WWTPs, techniques for monitoring, predicting, controlling, and optimizing the efficiency and eco-efficiency of WWTPs can be created or improved. However, the use of computational methodologies that use KPIs (KPIs-based methodologies) is still limited. This paper provides a literature review of the current state-of-the-art of KPI-based methodologies to monitor, control and optimize energy efficiency and eco-efficiency in WWTPs. In this paper, studies presented on 21 papers are identified, assessed and synthesized, 12 being related to monitoring and predicting problems, and 9 related to control and optimization problems. Future research directions relating to unresolved problems are also identified and discussed.
Global Dynamics of the Compressible Fluid Model of the Korteweg Type in Hybrid Besov Spaces
Authors: Song Zihao , Xu Jiang
Published: December 2022

We are concerned with a system of equations governing the evolution of isothermal, viscous, and compressible fluids of the Korteweg type, which is used to describe a two-phase liquid–vapor mixture. It is found that there is a “regularity-gain" dissipative structure of linearized systems in case of zero sound speed P′(ρ*)=0, in comparison with the classical compressible Navier–Stokes equations. First, we establish the global-in-time existence of strong solutions in hybrid Besov spaces by using Banach’s fixed point theorem. Furthermore, we prove that the global solutions with critical regularity are Gevrey analytic in fact. Secondly, based on Gevrey’s estimates, we obtain uniform bounds on the growth of the analyticity radius of solutions in negative Besov spaces, which lead to the optimal time-decay estimates of solutions and their derivatives of arbitrary order.
Measure of Similarity between GMMs Based on Geometry-Aware Dimensionality Reduction
Authors: Popović Branislav , Janev Marko , Krstanović Lidija , Simić Nikola , Delić Vlado
Published: December 2022

Gaussian Mixture Models (GMMs) are used in many traditional expert systems and modern artificial intelligence tasks such as automatic speech recognition, image recognition and retrieval, pattern recognition, speaker recognition and verification, financial forecasting applications and others, as simple statistical representations of underlying data. Those representations typically require many high-dimensional GMM components that consume large computing resources and increase computation time. On the other hand, real-time applications require computationally efficient algorithms and for that reason, various GMM similarity measures and dimensionality reduction techniques have been examined to reduce the computational complexity. In this paper, a novel GMM similarity measure is proposed. The measure is based on a recently presented nonlinear geometry-aware dimensionality reduction algorithm for the manifold of Symmetric Positive Definite (SPD) matrices. The algorithm is applied over SPD representations of the original data. The local neighborhood information from the original high-dimensional parameter space is preserved by preserving distance to the local mean. Instead of dealing with high-dimensional parameter space, the method operates on much lower-dimensional space of transformed parameters. Resolving the distance between such representations is reduced to calculating the distance among lower-dimensional matrices. The method was tested within a texture recognition task where superior state-of-the-art performance in terms of the trade-off between recognition accuracy and computational complexity has been achieved in comparison with all baseline GMM similarity measures.
An Alternative Numerical Scheme to Approximate the Early Exercise Boundary of American Options
Authors: Veliu Denis , De Marchis Roberto , Marino Mario , Martire Antonio Luciano
Published: December 2022

This paper deals with a new numerical method for the approximation of the early exercise boundary in the American option pricing problem. In more detail, using the mean-value theorem for integrals, we provide a flexible algorithm that allows for reaching a more accurate numerical solution with fewer calculations rather than other previously described methods.
Faces and Renormings of ℓ1
Authors: Navarro-Pascual Juan Carlos , Zarauz-Moreno Antonio
Published: December 2022

The faces of the unit ball of a finite-dimensional Banach space are automatically closed. The situation is different in the infinite-dimensional case. In fact, under this last condition, the closure of a face may not be a face. In this paper, we discuss these issues in an expository style. In order to illustrate the described situation we consider an equivalent renorming of the Banach space ℓ1.
Hepatic Involvement of Diffuse Large B-Cell Lymphoma Mimicking Antinuclear Antibody-Negative Autoimmune Hepatitis Diagnosed by Liver Biopsy
Authors: Lee Euna , Kang Min-Kyu , Moon Gabin , Gu Mi-Jin
Published: December 2022

Non-Hodgkin’s lymphoma (NHL) is the fifth most common hematologic disorder in the United States, and its prevalence has been rising in Western countries. Among the subtypes of NHL, diffuse large B-cell lymphoma (DLBCL) mostly involves the lymph nodes, stomach, and gastrointestinal tract, whereas hepatic involvement of DLBCL is rare. On serologic testing, elevated immunoglobulin G (IgG) levels can be observed in DLBCL; however, elevated IgG levels are mainly observed in autoimmune hepatitis. A targeted-lesion biopsy is required for the diagnosis of DLBCL. Based on a final diagnosis, the patient was treated with rituximab-based chemotherapy, including cyclophosphamide, doxorubicin, vincristine, and prednisone chemotherapy (R-CHOP). Herein, we report a case of DLBCL mimicking antinuclear antibody-negative autoimmune hepatitis, which was finally diagnosed as DLBCL involving the liver, and was confirmed by liver biopsy.
Ten-Year Change in Disorders of Consciousness: A Bibliometric Analysis
Authors: Zheng Xiaochun , Xu Chengwei , Li Shuiyan , Wu Wanchun , Xiao Qiuyi , Xie Qiuyou
Published: December 2022

Objectives: Disorders of consciousness (DoC) is a dynamic and challenging discipline, presenting intriguing challenges to clinicians and neurorehabilitation specialists for the lack of reliable assessment methods and interventions. Understanding DoC keeps pace with scientific research is urgent to need. We quantitively analyzed publications on DoC over the recent 10 years via bibliometrics analysis, to summarize the intellectual structure, current research hotspots, and future research trends in the field of DoC. Methods: Literature was obtained from the Science Citation Index Expanded of Web of Science Core Collection (WoSCC). To illustrate the knowledge structure of DoC, CiteSpace 5.8.R3 was used to conduct a co-occurrence analysis of countries, institutions, and keywords, and a co-citation analysis of references and journals. Also, Gephi 0.9.2 contributed to the author and co-cited author analysis. We found the most influential journals, authors, and countries and the most talked about keywords in the last decade of research. Results: A total of 1919 publications were collected. Over the past 10 years, the total number of annual publications has continued to increase, with the largest circulation in 2018. We found most DoC research and close cooperation originated from developed countries, e.g., the USA, Canada, and Italy. Academics from Belgium appear to have a strong presence in the field of DoC. The most influential journals were also mainly distributed in the USA and some European countries. Conclusions: This bibliometric study sheds light on the knowledge architecture of DoC research over the past decade, reflecting current hotspots and emerging trends, and providing new insights for clinicians and academics interested in DoC. The hot issues in DoC were diagnosing and differentiating the level of consciousness, and detecting covert awareness in early severe brain-injured patients. New trends focus on exploring the recovery mechanism of DoC and neuromodulation techniques.
Updated Review on the Mechanisms of Pathogenicity in Mycobacterium abscessus, a Rapidly Growing Emerging Pathogen
Authors: López-Roa Paula , Esteban Jaime , Muñoz-Egea María-Carmen
Published: December 2022

In recent years, Mycobacterium abscessus has appeared as an emerging pathogen, with an increasing number of disease cases reported worldwide that mainly occur among patients with chronic lung diseases or impaired immune systems. The treatment of this pathogen represents a challenge due to the multi-drug-resistant nature of this species and its ability to evade most therapeutic approaches. However, although predisposing host factors for disease are well known, intrinsic pathogenicity mechanisms of this mycobacterium are still not elucidated. Like other mycobacteria, intracellular invasiveness and survival inside different cell lines are pathogenic factors related to the ability of M. abscessus to establish infection. Some of the molecular factors involved in this process are well-known and are present in the mycobacterial cell wall, such as trehalose-dimycolate and glycopeptidolipids. The ability to form biofilms is another pathogenic factor that is essential for the development of chronic disease and for promoting mycobacterial survival against the host immune system or different antibacterial treatments. This capability also seems to be related to glycopeptidolipids and other lipid molecules, and some studies have shown an intrinsic relationship between both pathogenic mechanisms. Antimicrobial resistance is also considered a mechanism of pathogenicity because it allows the mycobacterium to resist antimicrobial therapies and represents an advantage in polymicrobial biofilms. The recent description of hyperpathogenic strains with the potential interhuman transmission makes it necessary to increase our knowledge of pathogenic mechanisms of this species to design better therapeutic approaches to the management of these infections.
Gaseous- and Condensed-Phase Activities of Some Reactive P- and N-Containing Fire Retardants in Polystyrenes
Authors: Tretsiakova-McNally Svetlana , Baby Aloshy , Joseph Paul , Pospiech Doris , Schierz Eileen , Lederer Albena , Arun Malavika , Fontaine Gaëlle
Published: December 2022

Polystyrene (PS) was modified by covalently binding P-, P-N- and/or N- containing fire-retardant moieties through co- or ter-polymerization reactions of styrene with diethyl(acryloyloxymethyl)phosphonate (DEAMP), diethyl-p-vinylbenzyl phosphonate (DEpVBP), acrylic acid-2-[(diethoxyphosphoryl)methylamino]ethyl ester (ADEPMAE) and maleimide (MI). In the present study, the condensed-phase and the gaseous-phase activities of the abovementioned fire retardants within the prepared co- and ter-polymers were evaluated for the first time. Pyrolysis–Gas Chromatography/Mass Spectrometry was employed to identify the volatile products formed during the thermal decomposition of the modified polymers. Benzaldehyde, α-methylstyrene, acetophenone, triethyl phosphate and styrene (monomer, dimer and trimer) were detected in the gaseous phase following the thermal cracking of fire-retardant groups and through main chain scissions. In the case of PS modified with ADEPMAE, the evolution of pyrolysis gases was suppressed by possible inhibitory actions of triethyl phosphate in the gaseous phase. The reactive modification of PS by simultaneously incorporating P- (DEAMP or DEpVBP) and N- (MI) monomeric units, in the chains of ter-polymers, resulted in a predominantly condensed-phase mode of action owing to synergistic P and N interactions. The solid-state 31P NMR spectroscopy, Scanning Electron Microscopy/Energy Dispersive Spectroscopy, Inductively-Coupled Plasma/Optical Emission Spectroscopy and X-ray Photoelectron Spectroscopy of char residues, obtained from ter-polymers, confirmed the retention of the phosphorus species in their structures.
Ameliorative Effect of Structurally Divergent Oleanane Triterpenoid, 3-Epifriedelinol from Ipomoea batatas against BPA-Induced Gonadotoxicity by Targeting PARP and NF-κB Signaling in Rats
Authors: Majid Muhammad , Farhan Anam , Baig Muhammad Waleed , Khan Muhammad Tariq , Kamal Yousaf , Hassan Syed Shams ul , Bungau Simona , Haq Ihsan-ul
Published: December 2022

The pentacyclic triterpenoids (PTs) of plant origin are reputed to restrain prostate cancer (PCa) cell proliferation. This study aims to assess 3-epifriedelinol (EFD) isolated from aerial part of Ipomoea batatas against PCa and its potential mechanism, in vitro and in vivo. Molecular docking affirms good binding affinity of the compound with target proteins exhibiting binding energy of −7.9 Kcal/mol with BAX, −8.1 Kcal/mol (BCL-2), −1.9 Kcal/mol (NF-κB) and −8.5 Kcal/mol with P53. In the MTT assay, EFD treatment (3–50 µM) showed a significant (p < 0.05 and p < 0.01) dose and time dependent drop in the proliferative graph of DU145 and PC3, and an upsurge in apoptotic cell population. EFD displayed substantial IC50 against DU145 (32.32 ± 3.72 µM) and PC3 (35.22 ± 3.47 µM). According to Western blots, EFD administration significantly enhanced the cleavage of caspases and PARP, elevated BAX and P53 and decreased BCL-2 and NF-κB expression, thereby triggering apoptosis in PCa cells. When male Sprague Dawley rats were intoxicated with Bisphenol A (BPA), an apparent increase in prostate mass (0.478 ± 0.08 g) in comparison to control (0.385 ± 0.03 g) indicates prostatitis. Multidose treatment of EFD (10 mg/kg) significantly reduced prostate size (0.404 ± 0.05 g). EFD exhibited substantial curative potential in vivo, as hematological, hormonal and histopathological parameters have been significantly improved. Reduced peroxidation (TBARS), and suppression of inflammatory markers i.e., NO, IL-6 and TNF-α, signposts substantial antiinflammatory potential of the compound. Overall, EFD has shown better binding affinity with target molecules, acceptable ADMET profile, potent antiproliferative and apoptotic nature and significant reduction in inflamed prostate mass of rats. The present study demonstrates acceptable physicochemical and pharmacokinetic properties of the compound with excellent drugable nature, hence EFD in the form of standardized formulation can be developed as primary or adjuvant therapy against PCa and toxins-induced gonadotoxicity.
A Landscape of CRISPR/Cas Technique for Emerging Viral Disease Diagnostics and Therapeutics: Progress and Prospects
Authors: Tripathi Shyam , Khatri Purnima , Fatima Zeeshan , Pandey Ramendra Pati , Hameed Saif
Published: December 2022

Viral diseases have emerged as a serious threat to humanity and as a leading cause of morbidity worldwide. Many viral diagnostic methods and antiviral therapies have been developed over time, but we are still a long way from treating certain infections caused by viruses. Acquired immunodeficiency syndrome (AIDS) is one of the challenges where current medical science advancements fall short. As a result, new diagnostic and treatment options are desperately needed. The CRISPR/Cas9 system has recently been proposed as a potential therapeutic approach for viral disease treatment. CRISPR/Cas9 is a specialised, effective, and adaptive gene-editing technique that can be used to modify, delete, or correct specific DNA sequences. It has evolved into an advanced, configurable nuclease-based single or multiple gene-editing tool with a wide range of applications. It is widely preferred simply because its operational procedures are simple, inexpensive, and extremely efficient. Exploration of infectious virus genomes is required for a comprehensive study of infectious viruses. Herein, we have discussed the historical timeline-based advancement of CRISPR, CRISPR/Cas9 as a gene-editing technology, the structure of CRISPR, and CRISPR as a diagnostic tool for studying emerging viral infections. Additionally, utilizing CRISPR/Cas9 technology to fight viral infections in plants, CRISPR-based diagnostics of viruses, pros, and cons, and bioethical issues of CRISPR/Cas9-based genomic modification are discussed.
Bio-Innovative Pretreatment of Coarse Wool Fibers
Authors: Vujasinović Edita , Tarbuk Anita , Pušić Tanja , Dekanić Tihana
Published: December 2022

From the textile manufacturers’ point of view, coarse and medullated fibers are undesirable in the production of fine woolen materials, but highly desirable in the production of textiles and yarns with special effects, especially in carpet production. For sustainability, the entire sheep fleece should be used, including the coarse and medullated fibers. The raw wool must be scoured to obtain clean wool fibers without damage or excessive fiber entanglement, with a certain moisture content, low dirt content and residual grease for further processing, and proper color. In order to remove the impurities in raw wool with maximum efficiency, save energy and minimize the environmental impact, this study investigated the changes in some fiber properties during the scouring process due to the effect of the enzyme complex on coarse wool fibers. The effects were studied through the amount of clean wool fibers and impurities within the fleece, the fiber diameter and color. Conventional and enzyme scoured coarse wool were bleached with an unconventional bleaching agent, percarbonate, and compared to bleaching with hydrogen peroxide to achieve higher whiteness and brilliant color with minimal fiber property changes. The changes after the bleaching process were determined based on the sorption of moisture and dyes and the color parameters. The bio-innovative pretreatment with enzyme complex scouring and percarbonate bleaching resulted in excellent fiber properties even for coarse wool. SEM analysis was performed to confirm these results. Taking into account the sustainability of the process and environmental protection, enzyme complex scouring and percarbonate bleaching are recommended as pretreatment processes for raw coarse wool.
The One-Way Analysis of Variance of Heat-Storage Materials Used in Building of Poultry Houses
Authors: Aleksandrova Olha , Zhmykhova Tetiana , Värnik Rando , Viira Ants-Hannes
Published: December 2022

In this study, a procedure for selecting the optimal heat-accumulating material based on phase transitions for the economical maintenance of poultry farms by applying ANOVA to complex solid bodies’ thermodynamic parameters is described. The relevance of the topic is due to its importance for the development of an energy-saving technology based on the release or absorption of significant heat during the crystallization or melting of materials. The applicability of one-way ANOVA for the selection of the optimal material with a specific functional purpose was demonstrated. As result, the best composition for maintaining a normal temperature regime in poultry farms that could meet all the requirements imposed on heat-storage materials was determined. It was found that magnesium sulphate heptahydrate is such a material.
Mental Paper Folding Revisited: The Involvement of Visual Action Imagery
Authors: Dahm Stephan Frederic , Draxler Clemens
Published: December 2022

Action imagery describes a mental representation of an action and its consequences. Although it is widely recognized that people differ in their ability to imagine actions, objective validated tests to measure such differences are scarce. In search of an objective testing method for action imagery ability, the present study investigated whether solving mental paper-folding tasks involves action imagery. The stimuli were two-dimensional grids of six squares. A total of 99 participants mentally folded each grid into a three-dimensional cube to judge whether two highlighted lines in the grid overlapped in the imagined cube. This was done in two sessions of 214 judgements each, where the grids differed in overlaps, the least number of imagined folds, and the least number of imagined directional changes. Error rates and reaction times increased with the number of imagined folds and with the number of directional changes. Furthermore, more errors were committed with overlapping lines than with no overlaps. This was not reflected in the reaction times. Hence, the reaction times increased when the stepwise folding process was enlarged, but not when the final selection was more difficult. We concluded that the participants predominantly used action imagery as a task-solving strategy rather than for abstract problem-solving.
The Alkyne Zipper Reaction: A Useful Tool in Synthetic Chemistry
Authors: Sørskår Åshild Moi , Stenstrøm Helge Ø. K. , Stenstrøm Yngve , Antonsen Simen Gjelseth
Published: December 2022

The alkyne zipper reaction is an internal-to-terminal alkyne isomerization reaction with many interesting applications in synthetic chemistry, as it constitutes an efficient means of achieving acetylene functionalization. A review of its applications in synthesis processes is presented in this paper, with a brief overview of the mechanistic features of the alkyne zipper reaction, as well as a brief overview of its future potential.
An Assessment of the Bivalent Vaccine as a Second Booster for COVID-19
Authors: Gupta Sneh Lata , Jaiswal Rishi K.
Published: December 2022

In the USA, two monovalent COVID-19 mRNA vaccines are primarily used for vaccination [...]
Membranous Nephropathy following Full-Dose of Inactivated SARS-CoV-2 Virus Vaccination: A Case Report and Literature Review
Authors: Thammathiwat Theerachai , Chompuk Laor , Worawichawong Suchin , Boonpucknavig Vijitr , Sirilak Supinda , Pongcharoen Sutatip , Pichitsiri Watchara , Kanjanabuch Talerngsak
Published: December 2022

Vaccination against the SARS-CoV-2 virus (COVID-19) has proven to be the most effective measure to prevent the spread and reduce infection severity. A case report of de novo membranous nephropathy (MN) following immunization with inactivated virus vaccine (CoronaVac®, Sinovac Biotech) is presented here. A 53-year-old man presented with a sudden onset of leg edema a week after receiving an inactivated virus vaccine and a relapse of nephrotic syndrome (NS) with acute kidney injury (AKI) after a booster dose. Screening for serum anti-phospholipase A2 receptor antibody and secondary causes of MN were negative. Kidney biopsy revealed an early MN pattern with focal spike formation, whilst numerous subepithelial electron-dense deposits and a few small deposits in the mesangial area were observed through electron microscopy. A short course of steroids and oral cyclophosphamide was prescribed, resulting in the complete remission of NS and AKI. MN following SARS-CoV-2 vaccination should call for medical importance. Awareness of the association between vaccination and MN should be kept in mind to avoid unnecessary treatment with long-term immunosuppressive agents.