bluuebunny/crossref_metadata_2025 huggingface dataset:
CT perfusion in hyper-acute ischemic stroke: the acid test for COVID-19 fear
Authors: Furlanis Giovanni , Ajčević Miloš , Scali Ilario , Buoite Stella Alex , Olivo Sasha , Lugnan Carlo , Caruso Paola , Pozzi Mucelli Roberta Antea , Accardo Agostino , Cova Maria Assunta , Naccarato Marcello , Manganotti Paolo
Published: February 2021

Purpose

The fear of COVID-19 infection may discourage patients from going to the hospital even in case of sudden onset of disabling symptoms. There is growing evidence of the reduction of stroke admissions and higher prevalence of severe clinical presentation. Yet, no studies have investigated the perfusion pattern of acute strokes admitted during the lockdown. We aimed to evaluate the effects of the COVID-19 pandemic on hyper-acute stroke CT perfusion (CTP) pattern during the first months of the pandemic in Italy.

Methods

In this retrospective observational study, we analyzed CTP images and clinical data of ischemic stroke patients admitted between 9 March and 2 June 2020 that underwent CTP (n = 30), to compare ischemic volumes and clinical features with stroke patients admitted during the same period in 2019 (n = 51). In particular, CTP images were processed to calculate total hypoperfused volumes, core volumes, and mismatch. The final infarct volumes were calculated on follow-up CT.

Results

Significantly higher total CTP hypoperfused volume (83.3 vs 18.5 ml, p = 0.003), core volume (27.8 vs 1.0 ml, p < 0.001), and unfavorable mismatch (0.51 vs 0.91, p < 0.001) were found during the COVID-19 period compared to no-COVID-19 one. The more unfavorable perfusion pattern at admission resulted in higher infarct volume on follow-up CT during COVID-19 (35.5 vs 3.0 ml, p < 0.001). During lockdown, a reduction of stroke admissions (− 37%) and a higher prevalence of severe clinical presentation (NIHSS ≥ 10; 53% vs 36%, p = 0.029) were observed.

Conclusion

The results of CTP analysis provided a better insight in the higher prevalence of major severity stroke patients during the COVID-19 period.
Structural and Genetic Determinants of Convergence in the Drosophila tRNA Structure–Function Map
Authors: Phillips Julie Baker , Ardell David H.
Published: February 2021

The evolution of tRNA multigene families remains poorly understood, exhibiting unusual phenomena such as functional conversions of tRNA genes through anticodon shift substitutions. We improved FlyBase tRNA gene annotations from twelveDrosophilaspecies, incorporating previously identified ortholog sets to compare substitution rates across tRNA bodies at single-site and base-pair resolution. All rapidly evolving sites fell within the same metal ion-binding pocket that lies at the interface of the two major stacked helical domains. We applied our tRNA Structure–Function Mapper (tSFM) method independently to eachDrosophilaspecies and one outgroup speciesMusca domesticaand found that, although predicted tRNA structure–function maps are generally highly conserved in flies, one tRNA Class-Informative Feature (CIF) within the rapidly evolving ion-binding pocket—Cytosine 17 (C17), ancestrally informative for lysylation identity—independently gained asparaginylation identity and substituted in parallel across tRNAAsnparalogs at least once, possibly multiple times, during evolution of the genus. InD. melanogaster, most tRNALysand tRNAAsngenes are co-arrayed in one large heterologous gene cluster, suggesting that heterologous gene conversion as well as structural similarities of tRNA-binding interfaces in the closely related asparaginyl-tRNA synthetase (AsnRS) and lysyl-tRNA synthetase (LysRS) proteins may have played a role in these changes. A previously identified Asn-to-Lys anticodon shift substitution inD. ananassaemay have arisen to compensate for the convergent and parallel gains of C17 in tRNAAsnparalogs in that lineage. Our results underscore the functional and evolutionary relevance of our tRNA structure–function map predictions and illuminate multiple genomic and structural factors contributing to rapid, parallel and compensatory evolution of tRNA multigene families.
Application of a Proposed Multi-Positional Circumferential Arm Liposuction Method and Quantification of its Clinical Efficacy Evaluation
Authors: Gu Yunpeng , Kang Ning , Lv Qianwen , Qi Yue , Liu Zhenjun , Chen Weiwei , Sun Xuejian , Chen Haodong , Ma Gui-e , Qi Zuoliang
Published: February 2021

Background

Upper arm liposuction mainly focuses on the posterolateral region, which may lead to a lack of harmony between the aspirated and unaspirated areas. In addition, the treatment effect of arm liposuction is often evaluated only by preoperative and postoperative photograph comparison and simple measurement; quantitative research on this topic is still lacking.

Methods

The multi-positional circumferential arm liposuction (MCAL) technique was proposed and applied to a total of 34 females in our hospital from 2017 to 2019. Three-dimensional data of 12 patients before the operation and after 2–3 months were collected and processed by 3D imaging, and the volume reduction rate was evaluated quantitatively.

Results

The MCAL method was successfully applied in the clinic, and its surgical effect was quantitatively studied. The mean follow-up time of 12 patients was (75.2 ±13.1) days, and the postoperative volume was significantly reduced. The postoperative volume of patients with type I, type II and type III decreased by (10.79 ±2.55)%, (17.25 ±3.02)% and (22.76 ±3.51)%, respectively.

Conclusion

Our new MCAL technique was successful, maximizing the esthetic results in upper limb contour refinements in the superficial fascial layer. The clinical efficacy of this proposed MCAL method was evaluated by CT and 3D digital technology, which provided further accuracy in demonstrating its effect on the shape of the arm.

Level of evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors https://www.springer.com.
Effective Community Engagement during the Environmental Assessment of a Mining Project in the Canadian Arctic
Authors: Prno Jason , Pickard Matthew , Kaiyogana John
Published: February 2021

The Back River Project is an approved gold mine in Nunavut, Canada owned by Sabina Gold & Silver Corp. Sabina developed a comprehensive community engagement program during the environmental assessment phase of the Project to share information, receive and address local feedback and concerns, and develop productive relationships in support of Project advancement. This paper outlines Sabina’s engagement program, successes and challenges encountered from the perspective of a mineral developer, and insights obtained for effective community engagement in a Canadian Arctic context. The program has been commended by observers and is consistent with best practice models. Sabina’s experiences revealed the importance of engaging early and often using a context-specific approach; comprehensive record-keeping and reporting; the meaningful incorporation of community perspectives and Traditional Knowledge; and focusing on long-term relationships, partnerships, and local benefits. Effective community engagement subsequently played a key role in Sabina securing major licenses and permits for Project advancement.
Evaluating clinical impact of a shortened infusion duration for ramucirumab: a model-based approach
Authors: Gao Ling , Lau Yiu-Keung , Wei Ran , O’Brien Lisa , Long Amanda , Piao Yongzhe , Abada Paolo
Published: February 2021

Purpose

We investigated the impact of infusion duration (30 and 60 min) on the pharmacokinetic profile of ramucirumab using a population pharmacokinetic (PopPK) modeling approach. We also assessed the relationship between infusion rate and incidence of immediate infusion-related reactions (IRRs; occurring on the day of administration) using ramucirumab phase II/III study data.

Methods

The impact of different infusion durations (30 vs. 60 min) on the time-course of ramucirumab concentration profiles were evaluated using a PopPK model, established using ramucirumab pharmacokinetic data from 2522 patients. Logistic regression was used to evaluate the association between ramucirumab infusion rate and incidence of immediate IRRs in clinical trials.

Results

Ramucirumab time-course concentration profiles were equivalent following a 30- or 60-min infusion. In the pooled clinical study dataset, 254 of 3216 (7.9%) patients receiving ramucirumab experienced at least one immediate IRR (any grade). When grouped according to infusion rate quartile, the incidence of immediate IRRs (any grade or grade ≥ 3) was similar across quartiles; findings were confirmed in sensitivity analyses. The risk of immediate IRRs was not found to be associated with infusion rate based on multivariate logistic analysis.

Conclusion

Shortening the infusion duration of ramucirumab from 60 to 30 min has no impact on ramucirumab exposure. Analysis of trial data found no relationship between an increased risk of immediate IRRs and a faster infusion rate. Such a change in infusion duration is unlikely to affect the clinical efficacy or overall safety profile of ramucirumab.
Disease stability and extended dosing under anti-VEGF treatment of exudative age-related macular degeneration (AMD) — a meta-analysis
Authors: Garweg Justus G. , Gerhardt Christin
Published: February 2021

Purpose

To assess disease stability (absence of intra- and/or subretinal fluid) and the portion of eyes being capable to extend their treatment interval to ≥ 12 weeks in exudative age-related macular degeneration (AMD).

Methods

A systematic literature search was performed in NCBI, PubMed, CENTRAL, and ClinicalTrials.gov to identify clinical studies reporting treatment outcomes for ranibizumab, aflibercept, and brolucizumab in exudative AMD under a treat-and-extend protocol and a follow-up of ≥ 12 months. Weighted mean differences and subgroup comparisons were used to integrate the different studies.

Results

This meta-analysis refers to 29 published series, including 27 independent samples and 5629 patients. In the pooled group, disease stability was reported in 62.9% and 56.0%, respectively, after 12 and 24 months of treatment, whereas treatment intervals were extended to ≥ 12 weeks in 37.7% and 42.6%, respectively. Ranibizumab, aflibercept, and brolucizumab differed regarding their potential to achieve disease stability (56.3%, 64.5%, and 71.5% after 12, and 50.0%, 52.7% and 75.7% after 24 months; p = < 0.001) and to allow an interval extension to ≥ 12 weeks (28.6%, 34.2%, and 53.3% after 12, and 34.2%, 47.7%, and 41.7% after 24 months; p = < 0.001).

Conclusion

The portion of eyes achieving disease stability regressed in the second year, whereas the portion of eyes under a ≥ 12-week interval increased. This discrepancy may reflect the challenges in balancing between under-treatment and a reduced treatment burden.
The association of perinatal and clinical factors with outcomes in infants with gastroschisis—a retrospective multicenter study in Finland
Authors: Tauriainen Asta , Sankilampi Ulla , Raitio Arimatias , Tauriainen Tuomas , Helenius Ilkka , Vanamo Kari , Hyvärinen Anna
Published: February 2021

The aim of the present study was to assess the prognostic factors for the outcome of gastroschisis in Finland. A retrospective multicenter study of gastroschisis patients born between 1993 and 2015 in four Finnish university hospitals was undertaken, collecting perinatal, surgical, and clinical data of neonates for uni- and multifactorial modeling analysis. The aim of the present study was to identify risk factors for mortality and the composite adverse outcome (death and/or short bowel syndrome or hospital stay > 60 days). Of the 154 infants with gastroschisis, the overall survival rate was 90.9%. In Cox regression analysis, independent risk factors for mortality included liver herniation, pulmonary hypoplasia, relaparotomy for perforation or necrosis, abdominal compartment syndrome, and central line sepsis. Furthermore, a logistic regression analysis identified central line sepsis, abdominal compartment syndrome, complex gastroschisis, and a younger gestational age as independent predictors of the composite adverse outcome.

Conclusion: The risk of death is increased in newborns with gastroschisis who have liver herniation, pulmonary hypoplasia, abdominal compartment syndrome, relaparotomy for perforation or necrosis, or central line–associated sepsis. Special care should be taken to minimize the risk of central line sepsis in the clinical setting.

What is known:• Gastroschisis is a relatively rare congenital anomaly of the abdominal wall and its incidence is increasing.• Complex gastroschisis has been reported to increase risk of mortality and complications.What is new:• Central line sepsis was found to be independently associated with mortality in gastroschisis patients.• Liver herniation was also significantly associated with mortality.
Polynomial spline spaces of non-uniform bi-degree on T-meshes: combinatorial bounds on the dimension
Authors: Toshniwal Deepesh , Mourrain Bernard , Hughes Thomas J. R.
Published: February 2021

Polynomial splines are ubiquitous in the fields of computer-aided geometric design and computational analysis. Splines on T-meshes, especially, have the potential to be incredibly versatile since local mesh adaptivity enables efficient modeling and approximation of local features. Meaningful use of such splines for modeling and approximation requires the construction of a suitable spanning set of linearly independent splines, and a theoretical understanding of the spline space dimension can be a useful tool when assessing possible approaches for building such splines. Here, we provide such a tool. Focusing on T-meshes, we study the dimension of the space of bivariate polynomial splines, and we discuss the general setting where local mesh adaptivity is combined with local polynomial degree adaptivity. The latter allows for the flexibility of choosing non-uniform bi-degrees for the splines, i.e., different bi-degrees on different faces of the T-mesh. In particular, approaching the problem using tools from homological algebra, we generalize the framework and the discourse presented by Mourrain (Math. Comput. 83(286):847–871, 2014) for uniform bi-degree splines. We derive combinatorial lower and upper bounds on the spline space dimension and subsequently outline sufficient conditions for the bounds to coincide.
Tests on Model Piled Rafts in Sand: Measured Settlements Compared with Finite Element Predictions
Authors: Omer Joshua , Haroglu Hasan
Published: February 2021

Laboratory tests were carried out on non-piled rafts, single piles, surface contacting and non surface-contacting piled rafts which were made of aluminum and instrumented with strain gauges and deflection gauges. The foundations were installed in dry sand contained in a large metal tank to minimize boundary effects. Maintained loads were applied to each foundation until failure was closely approached. In parallel, analyses were performed using PLAXIS™ 3-D finite element program to compare the calculated and measured load-settlement trends hence assess the influence of soil stiffness on the foundation behaviour. The results confirmed that group efficiency of non-surface contacting piled increased with increasing pile–pile spacing and approached unity at a spacing equivalent to 8D (D = pile diameter). The data obtained from the strain gauges provided valuable insight into the load-transfer characteristics of different foundations and subsequently proved that the capacity of a surface contacting piled raft is significantly enhanced compared to that of either a non-piled raft or a non-surface contacting piled raft.
Correlation between the DNA fragmentation index (DFI) and sperm morphology of infertile patients
Authors: Ferrigno Alberto , Ruvolo Giovanni , Capra Giuseppina , Serra Nicola , Bosco Liana
Published: February 2021

Purpose

To evaluate the correlation between the DNA Fragmentation Index (DFI) and sperm morphology in patients undergoing ICSI, as a predictive parameter in reproductive outcomes.

Methods

A retrospective study was conducted on 125 infertile patients enrolled in a fertility clinic. Seminal characteristics were measured following the WHO guidelines (2010) for the examination of the seminal fluid. After collecting motile sperm population by pellet swim up, DFI was calculated and simultaneously associated with sperm morphology using in situ TUNEL assay and an image analyzer software in at least 250 spermatozoa for each patient.

Results

All subjects were divided into two groups according to a cutoff established, by choice, of the sperm DFI (15%): group A (< 15%) consisting of 65 patients and group B (≥ 15%) of 60 patients. Data were analyzed using non-parametric statistical methods. The results demonstrate that there is no statistical difference between the two groups in seminal characteristics. The collective data show a high significant correlation, suggesting that spermatozoa with abnormal morphology are the best candidates to contain DNA damage (p < 0.001). Also, when group A is compared with group B, an increased percentage of morphologically normal spermatozoa with fragmented DNA was observed in patients, with DFI values ≥ 15% (p < 0.001).

Conclusion

These results are aimed at providing an exact value of DFI in morphologically normal spermatozoa, which will be helpful to the embryologist in evaluating the risk of transferring, during the ICSI procedure, a spermatozoon whit normal morphology but fragmented DNA.
Multifunctional stratified composite coatings by electrophoretic deposition and RF co-sputtering for orthopaedic implants
Authors: Nawaz Qaisar , Fastner Steffen , Rehman Muhammad Atiq Ur , Ferraris Sara , Perero Sergio , di Confiengo G. Gautier , Yavuz Emre , Ferraris Monica , Boccaccini Aldo R.
Published: February 2021

In this study, multifunctional stratified antibacterial and bioactive coatings were deposited and characterised. Initially, PEEK/bioactive glass (BG)/ mesoporous bioactive glass nanoparticle (MBGN) layers with a thickness of 110–120 μm were deposited on stainless steel substrates using electrophoretic deposition (EPD). Thin silver nanocluster-silica composite layers with a thickness of 70–155 nm were then deposited by radio frequency (RF) co-sputtering on the previously deposited EPD coatings. The deposition was carried for two different sputtering times (20 min and 40 min), which led to different layer thicknesses. PEEK/BG/MBGNs coatings were also deposited via single-step EPD. A comparison between the physicomechanical and biological characteristics of single layer PEEK/BG/MBGNs composite coating and bilayer Ag-PEEK/BG/MBGNs is presented. Scanning electron microscopy (SEM) and energy-dispersive x-ray spectroscopy (EDX) indicated that silver nanoclusters were homogeneously distributed in the multilayered EPD/RF coatings. An apatite-like structure was formed on the surface of the coatings upon immersion in simulated body fluid (SBF) after 1 day. Silver nanoclusters embedded in the silica matrix as a top layer provided controlled release of silver ions which led to a potent antibacterial effect against E. coli and S. carnosus. Single layer coatings exhibited a burst release of Ag ions, which led to antibacterial effects but were toxic to osteoblast cells. Finally, the results of WST-8 assays confirmed that the multi-structured coatings allow osteoblast-like cells to proliferate and attach strongly on the surface of the coatings.
Synchronized interdecadal variations behind regime shifts in the Pacific Decadal Oscillation
Authors: Hamamoto Masaki , Yasuda Ichiro
Published: February 2021

Interdecadal climate variability over the North Pacific is investigated using a reconstructed 298-year-long annual Pacific Decadal Oscillation Index during 1700–1997. Here, we show that its interdecadal component can be decomposed into the bi-decadal (~ 20 years), the tri-decadal (~ 30 years), and the multi-decadal variations (~ 60 years) through bandpass filtering. The phase reversals of the bi-decadal and the tri-decadal variations were synchronized throughout the data, while the synchronization of the bi-decadal and the multi-decadal variations was maintained during 1780–1880 and 1920–1997. Monte Carlo simulation reveals that this synchronous temporal structure is statistically significant and could not occur from random processes. We further demonstrate that these three phase-locked variations play an important role in the regime shifts in the North Pacific, both during the data period (1700–1997) and thereafter. The bi-decadal variation, which is self-sustained through the North Pacific mid-latitude air–sea interaction, is also found to be possibly linked to the lunar nodal cycle. Moreover, the tri-decadal and the multi-decadal variations, whose periods are approximately 1.5 and 3 times longer than that of the bi-decadal variation, may be linked to the bi-decadal variation through nonlinear process. This simple relationship could largely contribute to understanding and predicting the interdecadal climate variability.
Kwak Transform and Inertial Manifolds revisited
Authors: Kostianko Anna , Zelik Sergey
Published: February 2021

The paper gives sharp spectral gap conditions for existence of inertial manifolds for abstract semilinear parabolic equations with non-self-adjoint leading part. Main attention is paid to the case where this leading part have Jordan cells which appear after applying the so-called Kwak transform to various important equations such as 2D Navier–Stokes equations, reaction-diffusion-advection systems, etc. The different forms of Kwak transforms and relations between them are also discussed.
Gambling at Work: A Qualitative Study of Swedish Elite Athletes, Coaches, and Managers
Authors: Vinberg Maria , Wetterborg Dan , Enebrink Pia
Published: February 2021

Considering the financial connections between sport and the gambling industry, more should be learned about gambling and problem gambling in this setting. This study explores how male athletes, coaches, and sports managers experience gambling activities and problems in their sports. Interviews were conducted with 30 male elite athletes, coaches, and managers in four sports. The interviews were analysed using content analysis, and the results indicated two main themes: 1) desire for and concerns with money and 2) in the shadow of performance, and three categories. The first main theme emerged as a result of the respondents recurring reference to money as the reason to different actions: It is important to win money,’too little’ or ‘too much’ money is described as reason for gambling, athletes status is affected by money and sponsor money from the gambling companies are considered important. ‘In the shadow of the performance’ captures the reason to and value of performance: The thrill and money are rewards for the gambling performance, everyday sporting life emphasizes performance both in training and matches. Lack of successful performance is perceived as a threat and evokes a fear of being seen as weak and being ejected from the team. This study identifies gambling as normalized within male elite sport. Preventing gambling problems calls for action at all levels of the involved socio-ecological framework. Management, coaches, and athletes need more knowledge of gambling and how to create a sustainable framework to prevent gambling problems.
Getting the Message Right: Evidence-Based Insights to Improve Organizational Return-to-Work Communication Practices
Authors: Jetha Arif , Le Pouésard Morgane , Mustard Cameron , Backman Catherine , Gignac Monique A. M.
Published: February 2021

Purpose There is an absence of evidence-based guidance to support workplace stakeholders in the effective delivery of return-to-work (RTW) messages. Our study examines the specific RTW communication practices and their impact on the management of work disability. Methods Within two large and complex healthcare organizations, semi-structured interviews were conducted with workplace stakeholders (e.g., supervisors, union representatives, disability management professionals and workers’ compensation representatives) and workers who had previously experienced sickness absence related to an occupational injury or illness. For workplace stakeholders interview questions asked about their roles and responsibilities in the RTW process, and specific communication strategies and messages that were used at different phases of the RTW process. For worker participants, interview questions explored RTW experiences and the impact of communication on work re-integration. An interpretative descriptive approach was used to inductively examine themes from interviews to create ways of understanding phenomena that yielded applied findings. Results Forty participants were interviewed including workplace stakeholders and workers. Participants frequently described effective RTW communication as messages that were delivered by a workplace stakeholder that included the content required by an injured worker to navigate the organizational disability management process and utilized specific strategies to address the perceived attitudes and perceptions held by an injured worker regarding work re-integration. Workplace stakeholders described five specific communication strategies including relaying messages of support, optimizing the timing of communication, careful word choice, framing messages, and tailoring communication to the injured worker.  Conclusion RTW communication is an active process that requires a strategic approach. Effective communication practices represent an important strategy for workplace stakeholders to address the barriers held by injured workers and foster early and sustained RTW.
Developmental Cascades from Aggression to Internalizing Problems via Peer and Teacher Relationships from Early to Middle Adolescence
Authors: Murray Aja Louise , Obsuth Ingrid , Speyer Lydia , Murray George , McKenzie Karen , Eisner Manuel , Ribeaud Denis
Published: February 2021

Previous research has provided evidence for developmental cascades between externalizing and internalizing problems via mechanisms such as peer and academic problems; however, there remains a need to illuminate other key mediating processes that could serve as intervention targets. This study, thus, evaluated whether developmental associations between aggression and internalizing are mediated by teacher—as well as peer—relationships. Using data from z-proso, a longitudinal study of Swiss youth (n = 1523; 785 males), an autoregressive latent trajectory model with structured residuals (ALT-SR) was fit over ages 11, 13, and 15 to examine within-person developmental links between aggression, internalizing problems, and the mediating role of peer and teacher relationships, while disaggregating between- and within-person effects. Teacher and peer relationships did not play a role in the progression of externalizing to internalizing problems or vice versa, however, teacher and peer relationships showed a protective effect against developing internalizing problems at ages 13. The results suggest that good quality relationships with teachers in early adolescence can help prevent internalizing problems from developing.
Evaluating the Effectiveness of Diabetes Shared Medical Appointments (SMAs) as Implemented in Five Veterans Affairs Health Systems: a Multi-site Cluster Randomized Pragmatic Trial
Authors: Heisler Michele , Burgess Jennifer , Cass Jeffrey , Chardos John F. , Guirguis Alexander B. , Strohecker Lorrie A. , Tremblay Adam S. , Wu Wen-Chih , Zulman Donna M.
Published: February 2021

Objective

To examine whether diabetes shared medical appointments (SMAs) implemented as part of usual clinical practice in diverse health systems are more effective than usual care in improving and sustaining A1c improvements.

Research Design and Methods

A multi-site cluster randomized pragmatic trial examining implementation in clinical practice of diabetes SMAs in five Veterans Affairs (VA) health systems was conducted from 2016 to 2020 among 1537 adults with type 2 diabetes and elevated A1cs. Eligible patients were randomly assigned to either: (1) invitation to participate in a series of SMAs totaling 8–9 h; or (2) continuation of usual care. Relative change in A1c (primary outcome) and in systolic blood pressure, insulin starts, statin starts, and anti-hypertensive medication classes (secondary outcomes) were measured as part of usual clinical care at baseline, at 6 months and at 12 months (~7 months after conclusion of the final SMA in four of five sites). We examined outcomes in three samples of SMA participants: all those scheduled for a SMA, those attending at least one SMA, and those attending at least half of SMAs.

Results

Baseline mean A1c was 9.0%. Participants scheduled for an SMA achieved A1c reductions 0.35% points greater than the control group between baseline and 6-months follow up (p = .001). Those who attended at least one SMA achieved reductions 0.42 % points greater (p < .001), and those who attended at least half of scheduled SMAs achieved reductions 0.53 % points greater (p < .001) than the control group. At 12-month follow-up, the three SMA analysis samples achieved reductions from baseline ranging from 0.16 % points (p = 0.12) to 0.29 % points (p = .06) greater than the control group.

Conclusions

Diabetes SMAs as implemented in real-life diverse clinical practices improve glycemic control more than usual care immediately after the SMAs, but relative gains are not maintained. Our findings suggest the need for further study of whether a longer term SMA model or other follow-up strategies would sustain relative clinical improvements associated with this intervention.

Trial Registration

ClinicalTrials.gov ID NCT02132676
Liver damage favors the eliminations of HBV integration and clonal hepatocytes in chronic hepatitis B
Authors: Hu Gang , Huang Ming X. , Li Wei Y. , Gan Chong J. , Dong Wen X. , Peng Xiao M.
Published: February 2021

Background

HBV integration is suspected to be an obstinate risk factor for hepatocellular carcinoma (HCC) in the era of antiviral therapy. Integration events start to occur in the immunotolerance phase, but their fates in the immune clearance phase have not yet been clarified. Here, we report the influences of liver damage on HBV integration and clonal hepatocyte expansion in patients with chronic hepatitis B (CHB).

Methods

HBV integration breakpoints in liver biopsy samples from 54 CHB patients were detected using a modified next-generation sequencing assay.

Results

A total of 3729 (69 per sample) integration breakpoints were found in the human genome, including some hotspot genes and KEGG pathways, especially in patients with abnormal transaminases. The number of breakpoint types, an integration risk parameter, was negatively correlated with HBV DNA load and transaminase levels. The average, maximum and total frequencies of given breakpoint types, parameters of clonal hepatocyte expansion, were negatively correlated with HBV DNA load, transaminase levels and liver inflammation activity grade score. The HBV DNA load and inflammation activity grade score were further found to be positively correlated with transaminase levels. Moreover, nucleos(t)ide analog (NUC) treatment that normalized transaminases nonsignificantly reduced the types, but significantly increased the average frequency and negated the enrichments of integration breakpoints.

Conclusion

Liver damage mainly removed the inventories of viral integration and clonal hepatocytes in CHB. NUC treatment may have reduced HBV integration but clearly increased clonal hepatocyte expansion, which may explain why HCC risk cannot be ruled out by NUC treatment.
Therapeutic regulation of the NLRP3 inflammasome in chronic inflammatory diseases
Authors: Seok Jin Kyung , Kang Han Chang , Cho Yong-Yeon , Lee Hye Suk , Lee Joo Young
Published: February 2021

Inflammasomes are cytosolic pattern recognition receptors that recognize pathogen-associated molecular patterns (PAMPs) and danger-associated molecular patterns (DAMPs) derived from invading pathogens and damaged tissues, respectively. Upon activation, the inflammasome forms a complex containing a receptor protein, an adaptor, and an effector to induce the autocleavage and activation of procaspase-1 ultimately culminating in the maturation and secretion of IL-1β and IL-18 and pyroptosis. Inflammasome activation plays an important role in host immune responses to pathogen infections and tissue repair in response to cellular damage. The NLRP3 inflammasome is a well-characterized pattern recognition receptor and is well known for its critical role in the regulation of immunity and the development and progression of various inflammatory diseases. In this review, we summarize recent efforts to develop therapeutic applications targeting the NLRP3 inflammasome to cure and prevent chronic inflammatory diseases. This review extensively discusses NLRP3 inflammasome-related diseases and current development of small molecule inhibitors providing beneficial information on the design of therapeutic strategies for NLRP3 inflammasome-related diseases. Additionally, small molecule inhibitors are classified depending on direct or indirect targeting mechanism to describe the current status of the development of pharmacological inhibitors.
BIO FOr CARE: biomarkers of hypertrophic cardiomyopathy development and progression in carriers of Dutch founder truncating MYBPC3 variants—design and status
Authors: Jansen M. , Christiaans I. , van der Crabben S. N. , Michels M. , Huurman R. , Hoedemaekers Y. M. , Dooijes D. , Jongbloed J. D. H. , Boven L. G. , Lekanne Deprez R. H. , Wilde A. A. M. , Jans J. J. M. , van der Velden J. , de Boer R. A. , van Tintelen J. P. , Asselbergs F. W. , Baas A. F.
Published: February 2021

Background

Hypertrophic cardiomyopathy (HCM) is the most prevalent monogenic heart disease, commonly caused by truncating variants in the MYBPC3 gene. HCM is an important cause of sudden cardiac death; however, overall prognosis is good and penetrance in genotype-positive individuals is incomplete. The underlying mechanisms are poorly understood and risk stratification remains limited.

Aim

To create a nationwide cohort of carriers of truncating MYBPC3 variants for identification of predictive biomarkers for HCM development and progression.

Methods

In the multicentre, observational BIO FOr CARe (Identification of BIOmarkers of hypertrophic cardiomyopathy development and progression in Dutch MYBPC3 FOunder variant CARriers) cohort, carriers of the c.2373dupG, c.2827C > T, c.2864_2865delCT and c.3776delA MYBPC3 variants are included and prospectively undergo longitudinal blood collection. Clinical data are collected from first presentation onwards. The primary outcome constitutes a composite endpoint of HCM progression (maximum wall thickness ≥ 20 mm, septal reduction therapy, heart failure occurrence, sustained ventricular arrhythmia and sudden cardiac death).

Results

So far, 250 subjects (median age 54.9 years (interquartile range 43.3, 66.6), 54.8% male) have been included. HCM was diagnosed in 169 subjects and dilated cardiomyopathy in 4. The primary outcome was met in 115 subjects. Blood samples were collected from 131 subjects.

Conclusion

BIO FOr CARe is a genetically homogeneous, phenotypically heterogeneous cohort incorporating a clinical data registry and longitudinal blood collection. This provides a unique opportunity to study biomarkers for HCM development and prognosis. The established infrastructure can be extended to study other genetic variants. Other centres are invited to join our consortium.
Förderung der körperlichen Aktivität von Mädchen im Sportunterricht
Authors: Renninger Denise , Sturm David J. , Krieger Claus , Demetriou Yolanda
Published: February 2021

Die Förderung eines aktiven und gesunden Lebensstils ist eine wichtige Aufgabe der Schule und des Sportunterrichts. Interventionsprogramme in diesem Setting besitzen zudem einen hohen Stellenwert zur Förderung körperlicher Aktivität von Kindern und Jugendlichen. Um die Wirksamkeit dieser Interventionsprogramme zu erfassen, ist eine umfangreiche Evaluation notwendig. Ziel der vorliegenden Untersuchung ist die qualitative Bewertung der Implementierungsqualität des CReActivity-Interventionsprogrammes, welches, basierend auf der Selbstbestimmungstheorie, die Förderung der körperlichen Aktivität von Schülerinnen durch den Sportunterricht zum Ziel hat. Zu diesem Zweck wurden leitfadenorientierte Interviews mit Lehrerinnen und Schülerinnen der Interventionsklassen des Projekts durchgeführt. Anschließend wurden die Interviews mithilfe der thematischen Analyse deduktiv-induktiv untersucht, um Erkenntnisse zu gewinnen, wie die Teilnehmerinnen die Intervention erleben und deuten. Die Analyse der Interviews der Lehrerinnen ergab insgesamt acht Themen, in denen die Einhaltung der Programmvorgaben, die Häufigkeit der Implementierung, die Qualität der Programmweitergabe, das Sich-Involvieren der Teilnehmer, die Anwendbarkeit der Intervention und die Akzeptanz aufgegriffen werden. Aus den Interviews mit den Schülerinnen konnten Informationen hinsichtlich der Qualität der Programmweitergabe und des Sich-Involvierens der Teilnehmer gewonnen werden. Insgesamt lassen die Ergebnisse eine von den Lehrerinnen wahrgenommene Wirksamkeit der Maßnahme erkennen, die auf eine hohe Implementierungsqualität verweist. Dennoch lassen die Ergebnisse eine schwankende Implementierungsqualität der einzelnen Lehrerinnen erkennen.
Persistent COVID-19-associated neurocognitive symptoms in non-hospitalized patients
Authors: Hellmuth Joanna , Barnett T. Allen , Asken Breton M. , Kelly J. Daniel , Torres Leonel , Stephens Melanie L. , Greenhouse Bryan , Martin Jeffrey N. , Chow Felicia C. , Deeks Steven G. , Greene Meredith , Miller Bruce L. , Annan Wesley , Henrich Timothy J. , Peluso Michael J.
Published: February 2021

As cases of coronavirus disease 2019 (COVID-19) mount worldwide, attention is needed on potential long-term neurologic impacts for the majority of patients who experience mild to moderate illness managed as outpatients. To date, there has not been discussion of persistent neurocognitive deficits in patients with milder COVID-19. We present two cases of non-hospitalized patients recovering from COVID-19 with persistent neurocognitive symptoms. Commonly used cognitive screens were normal, while more detailed testing revealed working memory and executive functioning deficits. An observational cohort study of individuals recovering from COVID-19 (14 or more days following symptom onset) identified that among the first 100 individuals enrolled, 14 were non-hospitalized patients reporting persistent cognitive issues. These 14 participants had a median age of 39 years (interquartile range: 35–56), and cognitive symptoms were present for at least a median of 98 days (interquartile range: 71–120 following acute COVID-19 symptoms); no participants with follow-up evaluation reported symptom resolution. We discuss potential mechanisms to be explored in future studies, including direct viral effects, indirect consequences of immune activation, and immune dysregulation causing auto-antibody production.
Development of palladium catalysts modified by ruthenium and molybdenum as anode in direct ethanol fuel cell
Authors: Fornazier Filho Yonis , da Cruz Ana Caroliny Carvalho , Pedicini Rolando , Salgado José Ricardo Cezar , Luz Priscilla Paiva , Ribeiro Josimar
Published: February 2021

Physical and electrochemical properties of Pd catalysts combined with Ru and Mo on carbon support were investigated. To this end, Pd, Pd1.3Ru1.0, Pd3.2Ru1.3Mo1.0 and Pd1.5Ru0.8Mo1.0 were synthesized on Carbon Vulcan XC72 support by the method of thermal decomposition of polymeric precursors and then physically and electrochemically characterized. The highest reaction yields are obtained for Pd3.2Ru1.3Mo1.0/C and Pd1.5Ru0.8Mo1.0/C and, as demonstrated by thermal analysis, they also show the smallest metal/carbon ratio compared the other catalysts. XRD (X-ray Diffraction) and Raman analyses show the presence of PdO and RuO2 for the Pd/C and the Pd1.3Ru1.0/C catalysts, respectively, a fact not observed for the Pd3.2Ru1.3 Mo1.0 /C and the Pd1.5Ru0.8Mo1.0/C catalysts. The catalytic activities were tested for the ethanol oxidation in alkaline medium. Cyclic voltammetry (CV) shows Pd1.3Ru1.0/C exhibiting the highest peak of current density, followed by Pd3.2Ru1.3Mo1.0/C, Pd1.5Ru0.8Mo1.0/C and Pd/C. From, chronoamperometry (CA), it is possible to observe the lowest rate of poisoning for the Pd1.3Ru1.0/C, followed by Pd3.2Ru1.3Mo1.0/C, Pd1.5Ru0.8Mo1.0/C and Pd/C. These results suggested that catalytic activity of the binary and the ternary catalysts are improved in comparison with Pd/C. The presence of RuO2 activated the bifunctional mechanism and improved the catalytic activity in the Pd1.3Ru1.0/C catalyst. The addition of Mo in the catalysts enhanced the catalytic activity by the intrinsic mechanism, suggesting a synergistic effect between metals. In summary, we suggest that it is possible to synthesize ternary PdRuMo catalysts supported on Carbon Vulcan XC72, resulting in materials with lower poisoning rates and lower costs than Pd/C.

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Photocatalytic activity of Pr-modified TiO2 for the degradation of bisphenol A
Authors: Cordeiro Denise S. , Cassio Fernando L. , Ciccotti Larissa , Hewer Thiago L. R. , Corio Paola , Freire Renato S.
Published: February 2021

Praseodymium doped TiO2 nanoparticles were successfully prepared by the sol–gel method and characterized by X-ray powder diffraction, N2 adsorption–desorption isotherm, and UV–vis spectroscopy. The effects of the dopant on the crystallite size, specific surface area, average pore diameter, pore volume, and bandgap energy were investigated. The photocatalytic activity of the catalysts was evaluated by bisphenol A degradation and mineralization, which is a representative endocrine disruptor. Furthermore, under visible light irradiation the Pr-modified TiO2 photocatalysts exhibited higher photocatalytic efficiency than unmodified TiO2. When praseodymium was loaded (1.0–5.0%) onto the surface of TiO2, the rates of degradation and mineralization were increased 3–5 times.
DuPont uses virtual exhibitions and Webinars to highlight its recently developed technology and products
Authors: Atkinson Simon
Published: February 2021

DuPont Water Solutions, the business unit of DuPont Safety & Construction, rounded off a busy and successful year by presenting details of its recently developed technology and products at a series of events held – like so many others during 2020 – in a virtual environment. This article provides a summary of the company's involvement in these exhibitions and Webinars, based on material that it has supplied.
The Study of Living Control Systems
Authors: Marken Richard S.
Published: February 2021

This book is a guide to doing a new kind of psychological research that focuses on the purposes rather than the causes of behavior. The research methods described here are based on a theory of behaviour called Perceptual Control Theory (PCT) that views organisms as purposeful rather than mechanical systems. According to PCT, purposeful behaviour involves acting to control perceptual input variables. Thus, understanding the purposeful behaviour of living organisms is a matter of determining the perceptual variables they are controlling when they are carrying out various behaviors. This book outlines research methods that determine what perceptual variables an organism is controlling, how it controls those variables, and why. It also describes methods for studying how an organism develops the ability to control different perceptions and how consciousness might be involved in this process.
Biologically effective dose of bromoxynil applied alone and mixed with metribuzin for the control of glyphosate-resistant horseweed in soybean
Authors: Westerveld David B. , Soltani Nader , Hooker David C. , Robinson Darren E. , Sikkema Peter H.
Published: February 2021

Glyphosate-resistant (GR) horseweed was first confirmed in Ontario in 2010. GR horseweed interference can reduce soybean yield by up to 97%. Bromoxynil is a photosystem II–inhibiting herbicide that is primarily used for annual broadleaf weed control in monocot crops. The objective of this study was to determine the biologically effective dose (BED) of bromoxynil applied alone and when mixed with metribuzin applied preplant for control of GR horseweed in soybean in Ontario. Five field experiments were conducted over a 2-yr period (2019–2020) to determine the predicted dose of bromoxynil with or without metribuzin that would control GR horseweed 50%, 80%, and 95%. No soybean injury was observed. The predicted doses of bromoxynil to achieve 50% and 80% control of GR horseweed were 98 and 277 g ai ha−1, respectively, at 8 wk after application (WAA). When mixed with metribuzin (400 g ai ha−1), the predicted doses of bromoxynil for 50%, 80%, and 95% control of GR horseweed were 10, 25, and 54 g ai ha−1, respectively. Bromoxynil (280 g ai ha−1) plus metribuzin (400 g ai ha−1) controlled GR horseweed 97%, a finding that was similar to the industry standards of saflufenacil + metribuzin (99% control) and glyphosate/dicamba + saflufenacil (100% control) at 8 WAA. This study concludes that bromoxynil + metribuzin applied before planting provides excellent control of GR horseweed in soybean.
Strengthened Causal Connections Between the MJO and the North Atlantic With Climate Warming
Authors: Samarasinghe Savini M. , Connolly Charlotte , Barnes Elizabeth A. , Ebert‐Uphoff Imme , Sun Lantao
Published: February 2021

While the Madden‐Julian oscillation (MJO) is known to influence the midlatitude circulation and its predictability on subseasonal‐to‐seasonal timescales, little is known how this connection may change with anthropogenic warming. This study investigates changes in the causal pathways between the MJO and the North Atlantic oscillation (NAO) within historical and SSP585 simulations of the Community Earth System Model 2‐Whole Atmosphere Community Climate Model (CESM2‐WACCM) coupled climate model. Two data‐driven approaches are employed, namely, the STRIPES index and graphical causal models. These approaches collectively indicate that the MJO's influence on the North Atlantic strengthens in the future, consistent with an extended jet‐stream. In addition, the graphical causal models allow us to distinguish the causal pathways associated with the teleconnections. While both a stratospheric and tropospheric pathway connect the MJO to the North Atlantic in CESM2‐WACCM, the strengthening of the MJO‐NAO causal connection over the 21st century is shown to be due exclusively to teleconnections via the tropospheric pathway.
Genetic variation, brain, and intelligence differences
Authors: Deary Ian J. , Cox Simon R. , Hill W. David
Published: February 2021

Individual differences in human intelligence, as assessed using cognitive test scores, have a well-replicated, hierarchical phenotypic covariance structure. They are substantially stable across the life course, and are predictive of educational, social, and health outcomes. From this solid phenotypic foundation and importance for life, comes an interest in the environmental, social, and genetic aetiologies of intelligence, and in the foundations of intelligence differences in brain structure and functioning. Here, we summarise and critique the last 10 years or so of molecular genetic (DNA-based) research on intelligence, including the discovery of genetic loci associated with intelligence, DNA-based heritability, and intelligence’s genetic correlations with other traits. We summarise new brain imaging-intelligence findings, including whole-brain associations and grey and white matter associations. We summarise regional brain imaging associations with intelligence and interpret these with respect to theoretical accounts. We address research that combines genetics and brain imaging in studying intelligence differences. There are new, though modest, associations in all these areas, and mechanistic accounts are lacking. We attempt to identify growing points that might contribute toward a more integrated ‘systems biology’ account of some of the between-individual differences in intelligence.