bluuebunny/crossref_metadata_2025 huggingface dataset:
Abordagem geral da cardiopatia congênita cianótica
Authors: Oliveira Júnior Marcelo da Silva de , Soares Dácia Silva , Silva Gabriella Fabiana Molinário Alves da , Soares Mariana Neves , Mota Natalle Rafaella Aguiar , Sena Querém Hadassa Matos , Sampaio Juliana Profilo
Published: December 2023

Objetivo: Descrever as características predominantes e métodos diagnósticos de algumas cardiopatias congênitas, entre elas: Estenose Aórtica (EA), Anomalia de Ebstein (AE), Comunicação Interatrial (CIA) e a Tetralogia de Fallot. Revisão bibliográfica: A Cardiopatia Congênita é definida pela presença de alterações estruturais e funcionais no coração, existentes desde o nascimento e originadas no desenvolvimento embrionário. Estas são classificadas em cianóticas e acianóticas, em que a presença ou não de cianose aponta para outras manifestações clínicas específicas de cada subgrupo. Sendo que na acianótica, o paciente comprometido apresenta dispneia, tosse e expectoração, já na cianótica vê-se, frequentemente, abscesso cerebral. Considerações finais: O diagnóstico precoce, por vezes realizado no período pré natal e por meio de ultrassonografia fetal, torna-se essencial para uma melhor qualidade de vida e minimização de danos nos indivíduos que apresentam tal grupo patológico. Uma vez que o procedimento cirúrgico ou a intervenção clínica nos pacientes acometidos por esta anomalia geralmente precisam acontecer no primeiro ano de vida. As principais complicações apresentam-se em ineficiência da circulação sanguínea corporal, modificações pulmonares, inapetência e policitemia, portanto diagnóstico e medidas terapêuticascorretos precisam ser efetuadas a fim de se obter um melhor prognóstico.
Bronquiolite viral aguda
Authors: Peixoto Felipe Guedes , Filho Jonh Eisenhoer Batista Alacrino , Medina André Bastos , Silva Guilherme Curvelo Bernardes , Pedro Isabella Geraldi , Carvalho Ana Clara Vanini de , Neves João Pedro Carvalho , Stolerman Tiago Ribeiro Cordeiro , Carvalho Heitor de Sousa Cunha , Siqueira Emílio Conceição de
Published: December 2023

Objetivo: Analisar as características da Bronquiolite Viral Aguda (BVA) e discutir o seu tratamento adequado. Revisão bibliográfica: A BVA é uma condição comum, especialmente em crianças com menos de dois anos. Ela se manifesta por meio de uma ampla variedade de sintomas, afetando tanto vias aéreas inferiores quanto as superiores. Entre esses sintomas, destacam-se a sibilância, hipoxemia, retrações torácicas e outros sintomas indicativos de dificuldade respiratória. Sua fisiopatologia envolve uma resposta inflamatória nas vias aéreas, resultando na produção excessiva de muco e falha na sua depuração. Considerações finais: A BVA é uma doença pulmonar frequente nos ambulatórios de pediatria. Seu diagnóstico é baseado predominantemente nas manifestações clinicas e exame físico do paciente. Quanto ao tratamento, há debate quanto ao uso de algumas medicações especificas, mas é fundamental ressaltar que o tratamento atual deve ser estritamente de suporte. Portanto, é de suma importância o conhecimento acerca da BVA para que o profissional, ao se deparar com a doença, realize o manejo, evitando complicações e resultados desfavoráveis.
Desafios diagnósticos e terapêuticos da hipertensão arterial em pacientes pediátricos
Authors: Coelho Isa Cavalcanti , Lage Tainah Berbeti Pacheco de Lacerda , Oliveira Victória Dalvi Cade , Persola Joyce da Silva , Amaral Emilly Pezzin , Thome Beatriz , Dorigo Ingryd Sardi , Assad Sarah da Silva , Keller Bianca , Coelho Kathleen Priscila Correia
Published: December 2023

Objetivo: Avaliar os desafios no diagnóstico e tratamento da hipertensão arterial primária pediátrica, considerando a eficácia do diagnóstico, aderência ao tratamento, qualidade de vida, controle da pressão arterial e impacto a longo prazo. Métodos: Trata-se de uma revisão integrativa desenvolvida por meio de pesquisa na base de dados PubMed, utilizando a seguinte estratégia de pesquisa (((Hypertension) AND ((Child) OR (Adolescent)) AND (((Treatment) AND (Diagnosis)) OR (Management))) NOT ((Adult) OR (Newborn) OR (Pregnancy)). Foram encontrados 3075 artigos, no qual foram pré-selecionados 60 artigos após aplicados os critérios de inclusão e exclusão. Foram removidos 41 após a leitura e análise inicial, totalizando 19 para análise completa. Resultados: Os estudos apontam a relação da obesidade e do sedentarismo com os casos de hipertensão pediátrica. Por se apresentar como uma doença silenciosa e de sintomas inespecíficos, condutas e abordagens tardias podem levar a um aumento dos eventos cardiovasculares. Enfatiza-se as medidas dietéticas com principal abordagem terapêutica, com poucos estudos direcionados a medicamentos utilizados e que sejam confirmadamente seguros. Considerações finais: Evidencia-se a importância da mudança do estilo de vida, além de medidas rigorosas de rastreamento a fim de prevenir complicações futuras.
Coil embolization for ruptured distal anterior cerebral artery aneurysm at the supracallosal portion: Two case reports
Authors: Tsuji Yuichiro , Kuroda Yuzo , Wanibuchi Masahiko
Published: December 2023

Background:

Distal anterior cerebral artery (ACA) aneurysms occur more frequently in the genu portion and much less frequently in the supracallosal portion (A4–A5). This report describes two cases of ruptured cerebral aneurysms occurring at the supracallosal portion successfully treated with coil embolization.

Case Description:

Case 1 involved a 61-year-old female with sudden-onset headache and vomiting attributed to subarachnoid hemorrhage (SAH). Digital subtraction angiography (DSA) revealed a bihemispheric ACA and aneurysm in the supracallosal portion. Coil embolization was performed, and the patient was discharged without neurological deficit. Case 2 involved a 35-year-old man with severe headache and disturbance of consciousness caused by SAH. DSA showed an aneurysm in A4 of the accessory ACA, and coil embolization was performed. After rehabilitation, he was discharged with a modified Rankin scale score of 2.

Conclusion:

Coil embolization for a ruptured aneurysm at the supracallosal portion can yield good results if the patient is appropriately selected.
Efficacy and safety of topical combination therapy in patients with acute otitis externa
Authors: Gurov Alexander V. , Kriukov Andrey I. , Shadrin Georgy B. , Izotova Galina N. , Zotova Polina K.
Published: December 2023

Aim. To study the structure of the microbial landscape in patients with acute otitis externa, as well as to evaluate the efficacy and safety of the combined drug chloramphenicol/clotrimazole/beclomethasone/lidocaine (Candibiotic) as an empirical therapy of this disease.Materials and methods. In this retrospective study of real clinical practice, outpatient records of 963 patients who applied to the KDO of the Sverzhevsky Research Clinical Institute of Otorhinolaryngology with symptoms of otitis externa in the period from 2017 to 2022 were selected. Additional analysis was carried out on the clinical records of patients who received the combined drug Candibiotic. The endpoints of this analysis included data on the clinical and microbiological efficacy of therapy, as well as safety information.Results. According to microbiological testing, 60.6% of microorganisms belonged to bacterial flora, 26% were bacterial-fungal associations, 11.6% were monofungal flora, in 1.8% of cases there was no growth of microorganisms. The most frequently isolated microorganisms were: Pseudomonas spp (n=291; 29.16%), Staphylococcus spp. (n=214; 21.4%), Candida spp. (n=194; 19.4%), Aspergillus spp. (n=133; 13.3%). Most of the patients (71.0%) received Candibiotic. In 69.7% of patients, the resolution of the clinical symptoms of otitis externa occurred within 7 days of therapy with Candibiotic. Complete eradication of microorganisms occurred in 87% of cases. Adverse events were recorded only in 3 (0.04%) cases.Conclusion. The study demonstrated an extremely high level of clinical efficacy and safety of therapy in patients with acute external infectious otitis who received the Candibiotic, which can be used as an initial empirical therapy in patients with otitis externa.
Diagnosis and antibiotic therapy of nosocomial pneumonia in adults: from recommendations to real practice. A review
Authors: Rachina Svetlana А. , Fedina Ludmila V. , Sukhorukova Marina V. , Sychev Igor N. , Larin Egor S. , Alkhlavov Abdulbari  A.
Published: December 2023

Nosocomial pneumonia is a healthcare-associated infection with significant consequences for the patient and the healthcare system. The efficacy of treatment significantly depends on the timeliness and adequacy of the antibiotic therapy regimen. The growth of resistance of gram-negative pathogens of nosocomial pneumonia to antimicrobial agents increases the risk of prescribing inadequate empirical therapy, which worsens the results of patient treatment. Identification of risk factors for infection with multidrug-resistant microorganisms, careful local microbiological monitoring with detection of resistance mechanisms, implementation of antimicrobial therapy control strategy and use of rational combinations of antibacterial drugs are of great importance. In addition, the importance of using new drugs with activity against carbapenem-resistant strains, including ceftazidime/aviabactam, must be understood. This review outlines the current data on the etiology, features of diagnosis and antibacterial therapy of nosocomial pneumonia.
Clinical cases of microscopic colitis: Diagnosis and treatment issues. Case report
Authors: Osadchuk Alexey M. , Fadeeva Nina A. , Dashkina Nuriya A. , Loranskaya Irina D. , Khomeriki Sergey G.
Published: December 2023

Currently, there is an increase in the incidence of microscopic colitis. There are difficulties in diagnosing this disease due to the variability of histological signs, variability of morphological changes in the mucous membrane of the colon in different parts of the colon, and the combination in one patient of not only various forms of microscopic colitis, but also other intestinal diseases. The article describes the differential diagnosis, an example of its staging and successful treatment of various forms of microscopic colitis with budesonide (two clinical cases presented).
Acute bronchitis – modern possibilities of mucactive therapy
Authors: Zaitsev Andrey A. , Filon Ekaterina A. , Storozheva Yulia I.
Published: December 2023

Aim. Analysis of the clinical effectiveness and safety of erdosteine use in comparison with standard (real practice) mucoactive therapy in patients with acute bronchitis (АВ) in adults.Materials and methods. The observational program included 100 adult patients with АВ, 50 of them (group 1) received erdosteine, the group 2 also included 50 patients who received acetylcysteine, bromhexine and other mucolytics (real clinical practice). The following were assessed: cough severity, average time for resolution of night and daytime cough, satisfaction with treatment, NO concentration in exhaled air, levels of C-reactive protein (CRP) and interleukin-6 (IL-6).Results. The average duration of relief of severe daytime cough requiring continued therapy was: in group 1 – 3.7±0.46 days, night cough – 1.14±0.94 days. In the second group, daytime cough was relieved in 3.8±0.4 days, night cough – 1.08±0.7 days. The duration of mucoactive therapy in group 1 was 5.32±0.82 days, in group 2 this figure was 8.5±1.4 days (p0.05). The number of АВ patients with a significant reduction in the severity of productive cough (1 point on cough severity scale) on the 6th day from the beginning of treatment in group 1 (erdosteine) amounted to 32 (64%), in group 2 – 27 (54%). Satisfaction with the treatment was higher in the group receiving erdosteine: according to the indicators "very satisfied" and "extremely satisfied" the patients of the group 1 – 42 – were the leaders in comparison with the group 2, where these positions were marked by 28 patients. The level of CRP in patients with АВ in group 1 was 24.7±21.24 mg/l, in group 2 – 16.37±16.5 mg/l, which indicates the viral etiology of the process and no need in the prescription of antimicrobial drugs. For the first time in Russian practice, the following were determined: the level of IL-6, which in the group 1 was 10.3±6.7 pc/ml; in the group 2 – 10.03±3.94 pc/ml; the level of exhaled NO in group 1 was 16.5±5.1 ppb, in group 2 – 14.9±4.6 ppb (the norm is up to 25 ppb). These indicators, against the background of mucoactive therapy, decreased to normal values by 6th day.Conclusion. The findings expand our understanding of АВ in adults. New results have been obtained on the role of CRP, IL-6 and NO in exhaled air during АВ. The use of erdosteine was accompanied by a significant mucoactive effect in the form of a pronounced regression of cough in patients with АВ compared to the comparison group in shorter term.
Prognostic factors in patients with hematological malignancies and concomitant chronic hepatitis C
Authors: Nozhkin Mikhail S. , Lioznov Dmitry A. , Antonova Tamara V. , Gorchakova Olga V. , Goldstein Edward M. , Popova Marina O. , Shneyder Tatyana V.
Published: December 2023

The study evaluated the impact of HCV infection on the prognosis in patients with hematological malignancies. A total of 96 patients with anti-HCV antibodies were enrolled, with the age of 37.8 (3.0–81.0) years old, 39.6% had non-Hodgkin’s lymphoma. Chronic hepatitis C (CHC) was diagnosed in 46.9% patients prior to malignancy development, in 38.5% patients simultaneously with malignancy, and in 14.6% patients during malignancy treatment. Clinical and biochemical signs of HCH were mild in most of the patients, minimal liver fibrosis (F0–1 by METAVIR system) was discovered in 47.3% patients, severe fibrosis or cirrhosis (F3–4) was diagnosed in 40% of participants. Only 20 (20.8%) of patients received antiviral therapy against HCV prior to enrollment. Regression analysis demonstrated that age 55 years old, late onset of antiviral therapy, and poor nutritional status were significant predictors of death from hematological malignancy. Survey conducted among physicians of hematological oncology hospitals in Saint-Petersburg revealed gaps in knowledge on presentation and risks of HCV infection, as well as on opportunities of modern antiviral therapy.
A clinical case of three times treatment of hepatitis C with repeated infection in HIV-positive patient. Case Report
Authors: Pokrovskaya Anastasia V. , Popova Anna A.
Published: December 2023

The article presents a clinical case of hepatitis C treatment with repeated reinfection in an HIV-positive patient. Despite the possibility of hepatitis C cure with modern antiviral drugs and long-term duration and quality of patients’ life, remains the risk of reinfection. It is necessary to intensify prevention and regular laboratory screening for viral hepatitis among all population in order to start treatment in time and prevent new cases of hepatitis.
A case of pleuropulmonary dirofilariasis caused by Dirofilaria repens. Case report
Authors: Kozlov Sergey S. , Ermakova Larisa A. , Lobzin Yuri V. , Nagorny Sergey A. , Kornienko Igor V. , Telicheva Victoriya O. , Kaliuzhina Mariia A. , Pshenichcnaya Natalia Yu.
Published: December 2023

The differential diagnosis of neoplasms of various localizations is the primary task in clinical practice of all physicians. We present a description of the case of invasion with Dirofilaria repens in the lung of a 68-year-old patient. In 2016 the patient was diagnosed with cancer of the left kidney and underwent a left-sided nephrectomy. During the dynamic observation in 2019, a lump was found in the left lung, which was regarded as a metastasis. An atypical SIX resection of the left lung was performed. Microscopy of the removed lump revealed the presence of a nematode of the genus Dirofilaria, presumably D. repens. The species identity of D. repens was confirmed by polymerase chain reaction using species-specific primers. It is known that the morphological identification of parasites up to the species in the surgical material presents certain difficulties and requires high professional training of the researcher. Therefore, the diagnosis of dirofilariasis in atypical localizations of nematodes in the human body is of great importance in the differentiation of malignant and benign formations, and the use of the polymerase chain reaction method can significantly increase the accuracy in establishing the final diagnosis.
Features of the course of COVID-19 in patients with type 2 diabetes mellitus
Authors: Karaseva Elena A. , Martynov Vladimir A. , Filatova Tatyana E. , Maleev Viktor V. , Grishin Vladimir Yu. , Pronin Nikita S. , Verbitskaya Elena I. , Popova Valeriia I.
Published: December 2023

Aim. To identify the features of the course of COVID-19 in patients with type 2 diabetes mellitus (T2DM), depending on the intake of hypoglycemic therapy at the prehospital stage, in conjunction with the functional state of the kidneys.Materials and methods. A retrospective analysis of 291 case histories of patients with COVID-19 and T2DM hospitalized in the infection department of Semashko Regional Clinical Hospital from January to December 2021, including the main clinical and laboratory parameters.Results. Among hospitalized patients with COVID-19, patients with T2DM had a higher mortality rate. An analysis of the case histories of deceased patients with COVID-19 and T2DM showed that at admission, body mass index (BMI), C-reactive protein, and creatinine were higher than those of survivors and amounted to BMI – 33 [30; 39] and 33 [28; 36] kg/m3; p=0.039, C-reactive protein – 77 [47.5; 106.0] and 57 [27.0; 89.0] mg/l; p=0.015, in terms of creatinine level – 89 [70.0; 144.0] and 82 [66.0; 101.0] µmol/l; p=0.039, respectively. It was found that in the second week of hospitalization in the group of deceased patients with COVID-19 and T2DM, the creatinine level was statistically significantly higher than in surviving patients and amounted to 94.5 [71.5; 141.0] and 72.5 [57.0; 88.0] µmol/L; p0.001, respectively. The probability of death in hospitalized patients with type 2 COVID-19 and T2DM depended on BMI and creatinine levels at the second week of hospitalization. Patients with prehospital correction of hyperglycemia dipeptidyl peptidase-4 inhibitors (iDPP-4)/ glucagon-like peptide-1 receptor agonists (agGLP-1)/ sodium-glucose co-transporter 2 inhibitors (iSGLT-2) had significantly lower creatinine levels at week 2 of hospitalization.Conclusion. In patients with moderate to severe COVID-19 with concomitant T2DM, special attention should be paid to the combination of high BMI and creatinine in the second week of hospitalization, which is a prognostically unfavorable predictor of death in such patients.
Сardiac arrhythmias in people who have had a coronavirus infection COVID-19: A review
Authors: Yamoldinov Nail R. , Dudarev Mikhail V. , Sarksyan Denis S. , Maleev Viktor V.
Published: December 2023

Heart rhythm disorders are one of the most common complications of coronavirus infection. Heart rhythm disorders can develop in 6–17% of hospitalized patients, and in convalescents, COVID-19 can manifest itself up to 12 months after the completion of the acute phase of the disease. Among the mechanisms for the development of cardiac arrhythmias, there are a direct cytopathic effect of SARS-CoV-2 on the myocardium, systemic inflammatory response syndrome, electrolyte imbalance, hypoxia, the use of antibacterial, antimalarial and antiviral drugs, exudative pericarditis, autonomic dysfunction. The main COVID-19-mediated heart rhythm disorders are sinus tachycardia and bradycardia, atrial fibrillation, ventricular tachycardia, long QT syndrome. Despite a significant amount of research, the literature data on the prevalence of certain types of cardiac arrhythmias (especially in COVID-19 convalescents), as well as methods for their correction, are somewhat contradictory and need to be clarified. Taking into account the impact of arrhythmia on the quality of life and mortality, active monitoring of convalescents of coronavirus infection, identification and development of approaches to the treatment of heart rhythm disorders in patients who have had COVID-19, seem to be relevant and promising areas in modern cardiology.
Pathogenetic approaches to the correction of vascular homeostasis in patients with COVID-19: A review
Authors: Shuldyakov Andrey A. , Smagina Anna N. , Ramazanova Kristina Kh. , Lyapina Elena P. , Chabbarov Yusef R. , Sheshina Natalia A. , Zhuk Alena A.
Published: December 2023

The adverse outcomes in patients with COVID-19 in the initial phase of the disease are often due to the development of cytokine storm, endothelial dysfunction, shifts in the hemostasis system, microangiopathy, angiocentric inflammation, and pathological angiogenesis, which require targeted therapy. Unfortunately, to date, there is still no drug with proven high efficacy. This review is to analyse the literature data on the pathogenesis of vascular homeostasis lesions and possible ways to correct the existing shifts in patients with COVID-19. When the oxygen content in the tissue decreases, one of the most important mechanisms of adaptation is the activation of the succinate oxidase pathway, but under conditions of prolonged hypoxia and intoxication, the succinate reserve is rapidly depleted. That is why exogenous of succinic acid can enhance the adaptive capabilities of the organism and improve the prognosis in patients with COVID-19. Succinic acid preparations contribute to normalization of energy exchange and reduction of oxidative stress, especially in combination with inosine, nicotinamide and riboflavin and are widely used in clinical practice in various nosological forms. Taking into account the analysis of data on the mechanisms of clinical effects of succinate-containing preparations, this group of drugs can be considered as promising with regard to the correction of vascular disorders in COVID-19.
Tuberculosis infection in patients with inflammatory bowel diseases. Clinacal cases
Authors: Timanovskaia Maria U. , Shaykhtdinova Yuliya R. , Zhulina Elena U. , Kulakov Dmitrii S. , Kagramanova Anna V. , Knyzev Oleg V. , Parfenov Asfold I.
Published: December 2023

In most cases Tuberculosis (TB) affects the lungs, but 10–15% of patients have extrapulmonary TB localisations, that is difficult to diagnose. TB is more spread among patients having the human immunodeficiency virus and among those who receive immunosuppressive therapy, specifically in patients with inflammatory bowel disease requiring long-term treatment with immunosuppressants and/or biologics. The symptoms of intestinal TB are nonspecific and may include chronic diarrhea, weight loss, fever and ascites. Differential diagnosis includes Crohn's disease, malignant neoplasms, periappendiceal abscesses, yersiniosis, etc. The article presents cases showing similarity of the intestinal form of TB with Crohn's disease, complexity dealing, diagnosing and treating patients with inflammatory bowel disease also having latent tuberculosis infection
Basic principles of legal regulation in the field of human genomic information processing in the context of implementation of international legal norms to national legislation
Authors: Kovalenko Mykola , Martynenko Nataliia
Published: December 2023

The article focuses on the analysis of human rights factors that are formed within the framework of international legal relations. The development of genomic research and expanding their application in domestic jurisprudence is a fairly new area of research in the field of public administration. On the basis of the synthesis of general scientific and specialized legal methods of research, the principles of regulation of relations on the processing of genomic information for human registration in Ukraine are formulated and substantiated, taking into account the threats to the dignity and rights of the human personality, namely: priority of life and health of citizens over interests of science and society in conducting molecular genetic examinations (research); confidentiality or protection of the genetic information of each citizen as part of personal data; equality of citizens regardless of genetic characteristics; guarantees of personality of person when using genomic technologies; observance of human and citizen’s rights and freedoms in the exercise of the rights and freedoms of others; guarantees of a citizen’s accessibility to their own genetic information; preventive actions of the state to protect citizens from the risks of loss, damage, distortion, misuse, unauthorized access to genomic information; exchange of genomic information with other countries and international organizations. In the context of implementation of international legal norms, the proposed principles are of particular importance, since they allow to maintain the balance of legal regulation and serve as a guide for law enforcement. The proposal for the application of a number of principles of processing of human genome information must be enshrined in the Law of Ukraine «On State Registration of Genomic Information», which will facilitate the formation of legal bases into the national system of law.
Structural Changes in the National Economy of Ukraine: Threats and Opportunities
Authors: Shuvanov Andrii
Published: December 2023

The article examines the main trends of structural changes in the national economy of Ukraine, in particular by indicators of created added value and employment of the population by types of economic activity. Tendency signs of inefficient structuring of the economy, which is a critical obstacle for the future economic development of the state, have been revealed.
An analysis of threats and opportunities in the process of structuring the economy was made according to the trends of changes in the specific weight of products by types of economic activity, which of them deepen the disparities of the national economy, and which are of a constructive nature.
The distribution of labor resources by types of economic activity is highlighted, in particular, taking into account the labor intensity of products, labor productivity, and the progressiveness of changes in the population employment structure is determined.
The existence of deep structural disproportions of the national economy, which proves its inefficiency, is revealed, and the need to eliminate disparities using the tools of state influence in the course of implementing the structural policy of the innovation-investment model of the economy is substantiated. The inertial scenario of further structural changes can lead to extremely negative consequences for the national economy.
Banking Sector in the Conditions of War: Features of State Regulation
Authors: Veretelnikov Ihor
Published: December 2023

The article theoretically substantiates the peculiarities of the banking sector as an object of state regulation and proposes directions and measures of state influence on ensuring the stability of the banking sector and its further development, taking into account the challenges caused by the full-scale invasion of the Russian Federation into Ukraine.
It has been proven that an efficiently functioning banking sector is an important factor in the economic development of the state. Effective government regulation stimulates the attraction of capital into the economy, lending to enterprises and private individuals, promotes the development of financial instruments and services, and also regulates risks in the activities of banks both in the short term and in the long term.
Thanks to the timely and prompt adoption of relevant legal acts aimed at stabilizing the banking sector, the country’s banking system withstood the war and continues to work. At the same time, there is a need for a systematic review of approaches to state regulation of this area, in particular, adjustment of its goals, objectives and implementation mechanisms in order to maintain the stability of the functioning of the banking system in the long term.
In order to implement the principles of ensuring security and stability, ensuring liquidity and financial stability, regulatory flexibility, transparency and communication, protection of bank clients in the practice of state administration during a long war, it is proposed to apply a set of state measures. Measures are classified according to such directions as ensuring financial support for banks, ensuring cyber security in the face of increasing digital threats, regulatory support for banking activities, protecting the rights and interests of bank clients, establishing communication and cooperation channels.
The importance of constant monitoring and flexible response to changes was emphasized in order to ensure the effective functioning of banks and protect the interests of all interested parties. In view of this, the direction of further research may be the development of a system of criteria for ongoing monitoring and final evaluation of the effectiveness of the application of measures of state regulation of the banking sector in terms of individual directions.
El caso de las Magdalene Laundries en Irlanda a través de un análisis de The Secret Scripture de Sebastian Barry
Authors: Bonacho Zoe
Published: December 2023

Este trabajo toma como referencia el poder transformador de la literatura en tanto en cuanto es una herramienta fundamental para conocer experiencias sufridas por otras personas. La literatura contribuye decisivamente a configurar un palimpsesto de historias veladas, de afectos y modos de vida que nos permiten comprender mejor nuestra Historia y poder ejercer una función política de resistencia y de resiliencia. A partir de un análisis riguroso textual de la novela de Sebastian Barry The Secret Scripture (2008) así como de algunas estrategias narratológicas, este enfoque metodológico se complementará con el uso de otros marcos teóricos tales como los estudios feministas, los estudios de los afectos y de la vulnerabilidad. El objetivo principal de este ensayo se centrará en desvelar los códigos intertextuales inscritos en la conciencia personal por la cultura y la sociedad irlandesa, lo que llevó a confinar y castigar a todas aquellas mujeres que no se ajustaron a su rol como esposas y madres dentro del matrimonio, robándoles su vida y la de sus hijos/as. Aunque tal experiencia supone un hecho traumático en sí mismo, se atenderá a cómo la obra de Barry supone una apuesta política que implica una redefinición del concepto tradicional de vulnerabilidad.
"The Salt of the Earth" in the 19th-century Hinterlands
Authors: Silva Rafael Sancho Carvalho da Sancho Carvalho da , Brandão de Aras Lina Maria
Published: December 2023

Versão em inglês.
DIGITAL MARKETING IN HEALTHCARE AND ITS APPLICATIONS IN THE WORLD AND TURKEY
Authors: YİĞİT Abdullah Çetin , AÇIKGÖZ Murat
Published: December 2023

Developing technologies and changing consumer attitudes and demands have caused major changes in many sectors. Some of these have disappeared and new sectors that were previously unknown or unheard of have emerged in their place. Digital technologies play the leading role in this change. While digital technologies are accepted in many sectors, it is unthinkable for the healthcare sector to stay away from this. Digital technology has caused radical changes in marketing in healthcare. The type of marketing that aims to provide services by taking advantage of all the opportunities of digitalization via the internet in order to effectively communicate the products or services of businesses and service providers to large communities is called digital marketing. All actions taken to perceive the problems related to the physical and mental health of the target community, to find solutions to these problems, and to influence the target community by explaining how benefits can be provided are called healthcare marketing. E-health or digital health is used as a generalizing term for the use of information communication technologies in health-related services and processes. The scope of digital health technologies used in digital health services is wide. In this context, digital technologies such as digital health records, mobile health services, artificial intelligence applications, wearable technologies and telemedicine can be considered.
Beton Esaslı Prefabrike Cephe Panelleri Üzerine Bir İnceleme
Authors: GÜLTEK Mediha , MUTLU AVİNÇ Güneş , SARICIOĞLU Pelin , YILDIZ Asli
Published: December 2023

Prefabrike sistemler, düşük maliyet, hızlı üretim, kaynakların rasyonel kullanımı, zayiat vermeyen yapım teknikleri gibi sunduğu olanaklar ile yapım süreçlerinde sıklıkla kullanılmaktadırlar. Bu sistemler ile bir yapının kolon, döşeme, duvar, cephe yüzeyi gibi pek çok bileşeni üretilebilmektedir. Bu araştırmada iç ve dış faktörlere bağlı olarak şekillendikleri için cephe panellerine odaklanılmıştır. Cephe panelleri içerisinde en yaygın olarak beton esaslı paneller kullanıldığı için çalışma beton panellerle sınırlandırılmıştır. Çalışmada prefabrike sistemlerin tarihsel süreç içerisindeki gelişimi ortaya konulmuştur. Daha sonra beton esaslı panellerin özellikleri, bileşenleri ve teknik detayları hakkında bilgiler verilmiştir. Mimari projeler hakkında bilgiler içeren web sayfaları taranmış ve bu panellerin kullanıldığı dokuz (9) adet yapı belirlenmiştir. Yapıların belirlenmesinde panel kullanımı açısından yenilikler sunan, sürdürülebilir, özgün form ve kurguya sahip ve teknolojik açıdan gelişmiş yapılar tercih edilmiştir. Yapılara ait değerlendirmeler bir tablo içerisinde özetlenmiştir. Sonuç olarak, gelişen malzeme teknoloji ile birlikte tekstil, cam, karbon gibi malzemeler beton ile birlikte kullanılarak yenilikçi prefabrik cephe elemanlarına dönüştüğü tespit edilmiştir. Bununla birlikte dünyada giderek cephelerde hızlı ve kolay üretim özelliklerinden dolayı beton esaslı prefabrik panellerin kullanım olanakları ve tasarımsal çeşitlilikleri gelişirken, ülkemizde bu sistemlerin kullanımının sınırlı kaldığı saptanmıştır.
Bilinmeyen PLC Programının Makine Öğrenmesi Yöntemleriyle Taklit Edilmesi
Authors: ULAMIŞ Faruk , YÜCE Yasin , CESUR Bülent
Published: December 2023

Programlanabilir Mantık Denetleyiciler (PLC) uzun yıllardır endüstrinin hemen her alanında kullanılmaktadır. Kullanılan bu PLC’ lerin eskimesi, bozulması veya şifreyle korunması gibi durumlarda PLC programlarının yedeklenmesi mümkün olmamaktadır. Herhangi bir arıza sonucu PLC programının silinmesi durumunda veya PLC' nin yenilenmesi ihtiyacı oluştuğunda programın yeniden yazılması gerekir. Böyle bir durumunda sistemin çalışma adımlarının detaylı bir şekilde bilinmesi gerekir ve program yazılması esnasında atlanacak bir adım sistemin tamamında çok büyük problemlere sebep olabilir. Bu çalışmada, çeşitli makine öğrenmesi algoritmaları kullanılarak PLC içerisinde çalışan ve bilinmeyen bir programın çalışma adımlarının taklit edilmesi işlemi yapılmıştır. Bunun için ilk olarak bir veri günlüğü oluşturularak PLC’ nin giriş ve çıkış bilgileri kaydedilmiştir. Daha sonra bu giriş-çıkış verileri Makine Öğrenmesi algoritmaları ile eğitilmiştir. Eğitilen bu algoritmaların giriş veri setine karşılık verdiği çıktıları, PLC çıkışlarıyla paralel olarak izlenmiştir. Makine öğrenmesi algoritması olarak karar ağacı, k-en yakın komşu ve rastgele orman algoritmaları kullanılmıştır. Algoritmaların performans ölçüm metriği olarak doğruluk puanı (accuracy score) kullanılmıştır. Yapılan çalışmalar sonunda Rastgele Orman algoritmasının daha iyi sonuç verdiği gözlemlenmiştir.
The Effect of Preliminary Treatment and Storage Time on the Quality of Infused Water Drinks of Butterfly Pea Flower (Clitoria ternatea), Siamese Oranges (Citrus nobilis), and Mint Leaves (Mentha piperita L.)
Authors: Salsabila Aurellia , Ulya Sarofa  , Andre Yusuf Trisna Putra
Published: December 2023

Infused wateris a natural alternative drink that contains various vitamins. In this research, an infused water drink will be made made from butterfly pea flowers, Siamese oranges and mint leaves. The aim of this research is to analyze the effect of pretreatment and storage time on the quality of the infused water produced and to identify the best treatment between pretreatment and storage time based on the physicochemical, microbiological and organoleptic characteristics of infused water drinks. This research used a completely randomized design (CRD) with a factorial pattern with two factors and three replications. Factor I is storage temperature (room temperature (27°C), refrigerator temperature (5°C), and room temperature that has been pasteurized (60°C for 15 minutes)). Factor II is storage time (1 hour, 3 hours and 6 hours). If there is a real difference, the further test will be continued with 5% DMRT. The best treatment results were obtained in the pre-pasteurization treatment at room temperature with a storage time of six hours which produced infused water with valuepH 5.257; vitamin C 19.57 mg/100g; antioxidant capacity (IC50) 2.187; total acid 0.312%; total phenol 1,261 mgGAE/gr; total plate count 1,950 Log CFU/ml; color preference score 3.80; aroma preference score 3.6; taste preference score 3.45.
Editorial: Volume 3(2)
Authors: Yeo Michelle
Published: December 2023

This fifth issue of Imagining SoTL consists of papers based on presentations at the 2022 Symposium for the Scholarship of Teaching and Learning, with a theme of “A Decade of Imagining SoTL: Looking Back, Looking Ahead,” our first in-person conference since the COVID-19 pandemic. It was good to be together. This issue follows our recent Call and Response issue (see Volume 3(1)). Here, we present the articles submitted in response to our more conventional call for contributors to develop their Scholarship of Teaching and Learning (SoTL) presentations from the conference.
Pendapatan dan Kerentanan Petani Kopi Robusta di Sekitar Kawasan Taman Nasional Bukit Barisan Selatan
Authors: As-Sadili Abu Hasan , Syaukat Yusman , Falatehan Faroby
Published: December 2023

Robusta coffee is a plantation commodity that has high potential considering the trend of consumption and large production in several provinces in Indonesia, one of which is Lampung Province, but the increasing production has an impact on land use in the forest area of Bukit Barisan Selatan National Park (TNBBS) for coffee farming activities. Moreover, the pandemic that hit around the world create new challenges in this coffee farming business. The purpose of this study was to analyze and compare the income level of coffee farming and the vulnerability of coffee farmer families due to the Covid-19 pandemic around TNBBS, both inside and outside TNBBS. Data analysis used farm income analysis and livelihood vulnerability index (LVI) analysis. The results of this study indicate that the income of farmers in the BBSNP area is smaller, namely Rp. 9,833,453.57 while outside the TNBBS area of ​​Rp. 12,571,781.31, the R/C ratio also shows that farming outside the region is the most profitable. Differences in the distance of farmers' land within the area and outside the area contributed greatly to this difference in number. The vulnerability of farming families inside and outside TNBBS is low to moderate in both LVI and LVI calculations considering the IPCC definition. Inadequate livelihood strategies and social networks in some farming households contributed to the LVI figures resulting from the analysis.
Keberhasilan Penyuluhan Melalui Karakteristik Penyuluh dan Petani
Authors: Irdiana Enny , Nurliza Nurliza , Kurniati Dewi
Published: December 2023

Agricultural extension is a system of conveying information and innovation with communication to increase knowledge and skills and change the attitudes and behavior of farmers. The success of agricultural development is supported by the quality of human resources, especially extension agents as the main actors, and farmers as targets. Human resources that consist of individual external and internal factors are the driving force and synergist of other resources to achieve the objectives of counseling. The research aims to formulate the success of counseling through the characteristics of frmers and extension workers with a quantitative descriptive method using the Speech Communication Model theory. Primary data was obtained using interviews and structured questionnaires for 65 extension workers and farmers using proportionate stratified random sampling in 9 sub-districts, Kubu Raya Regency, West Kalimantan, while the entire extension population was taken, then analyzed using SEM-PLS. The results showed that the characteristics of extension agents had a positive effect in terms of demography, competence, and service input, as well as farmer’s characteristics in terms of demography, characteristics, and communication affordability which had a high effect on the success of extension. Characteristics of farmers and extension workers have a positive correlation with extension activities, which means that the higher ability, competence, skills, and motivation of farmers and extension workers, the success of extension can increase to achieve the goals of extension, realize an increase in the lives and welfare of farmers. Efforts can be made through training activities, technical guidance, and so on as needed. In addition, government support in the provision of financing, facilities, infrastructure, and supporting activity programs in efforts to increase competence and service input in the success of extension.
Komoditas Unggulan dan Daya Saing Sektor Pertanian Kabupaten Tanah Datar
Authors: Nurmayenti Marisa , Syahrial Syahrial , Dermawan Alvindo
Published: December 2023

The agricultural sector has an important role in economic development. Determination of superior commodities in an area is the first step of development based on the concept of comparative and competitive advantage. This study aims to (1) analyze the leading commodities in Tanah Datar Regency (2) analyze the competitiveness of the leading commodities in Tanah Datar Regency (3) analyze the specialization and localization of superior commodities in Tanah Datar Regency. This research uses Location Quotient analysis, Dynamic Location Quotient, Shift Share Analysis, Specialization Quotient and Localization Quotient. The data used are secondary data, namely the production of the food crop sub-sector, horticulture sub-sector, and plantation sub-sector from 2016 to 2020. The results of the analysis show that (1) the percentage of agricultural sector commodities that are superior in Tanah Datar Regency is 40 percent, with the percentage of potential future superior commodities in Tanah Datar Regency is 63 percent (2) the percentage of competitive superior commodities in Tanah Datar Regency is 47 percent (3) the percentage of specialization and localization of superior commodities is 21 percent. From the results of the analysis, it is hoped that the government will direct the development of the agricultural sector with a focus on efforts to increase productivity, develop, and socialize superior agricultural commodities.
Analisis Dampak Kebijakan Non-Tarif Measures Terhadap Kinerja Ekspor Udang Beku Indonesia di Pasar Tujuan Utama
Authors: Aprilia Nita , Syaukat Yusman , Falatehan Faroby
Published: December 2023

The shrimp commodity significantly contributes to the total export value of the fisheries sub-sector in Indonesia. In 2021, Indonesia will become the fourth largest exporter of frozen shrimp on the world market. However, the value of Indonesia's frozen shrimp exports continues to fluctuate every year. Indonesia's frozen shrimp exports also face various challenges from non-tariff measures (NTM) policies, incredibly sanitary and phytosanitary (SPS) and technical barriers to trade (TBT) imposed by importing countries. This study aims to analyze the performance of Indonesia's frozen shrimp trade in destination markets and the impact of NTM policies and other factors on Indonesian shrimp exports in destination markets. This research uses panel data model regression. The results showed there was still rejection of fishery products including frozen shrimp from Indonesia in importing countries due to excess chemical content. But the number of rejections is less than one percent compared to the total received. This is in line with the panel data regression results for the SPS variable which is not significant and the TBT variable which has a significant and positive effect.  The non-significant results indicate that exporters in Indonesia can adjust the policies imposed by the importing country relating to product certification criteria, sampling procedures, packaging requirements, distribution requirements, and labeling requirements. For this reason, the Indonesian government needs to improve regarding rejection is the need for accurate and thorough sample testing of Indonesian frozen shrimp before export, as well as increasing assistance regarding threshold limits for chemical use for shrimp cultivators at the upstream level.
Analisis Investasi Produksi Benih Jagung Hibrida di Kota Solok
Authors: Herawati Herawati , Krisnamurthi Bayu , Hanifah Ryan Azmii
Published: December 2023

One way to fulfill the corn supply is by increasing productivity using superior seeds such as hybrid corn seeds. PT Agricorn Putra Sejati is a producer of hybrid corn seeds that plans to expand its production capacity. This research aims to determine the feasibility of business development and analyze the maximum changes in fertilizer prices and permanent labor wages. The study uses  scenarios : scenario 0 (condition without development), scenario I (development condition with a labor-intensive system), and scenario II (development condition with more machine usage). The research considers non-financial aspects (market aspects, technical aspects, management and legal aspects, social, economic, and cultural aspects, as well as environmental aspects), financial aspects (NPV, Net B/C, IRR, Payback Period), and replacement value analysis. A company will be considered viable if NPV >0, Net B/C >1, IRR >1, and Payback Period >business life. The results show that the company is feasible to develop and will obtain a higher net benefit if using scenario II. Based on the replacement value analysis, the company is more sensitive to an increase in labor wages than an increase in fertilizer prices.
Analisis Kemitraan PT Simply Fresh Organic dengan Petani Sayuran Organik di Kabupaten Cianjur Jawa Barat
Authors: Marito Sinta , Budi Priatna Wahyu , Tinaprilla Netti
Published: December 2023

Partnership is relationship among two people or more that have purpose which is harmonious and form a deal for doing business together. Partnership also defined as a relationship cooperative relationship which gives profit to each other. Cooperation which is profit each other will give positive impact for business performer to continue developing and increasing business result that is done together. Partnership has important role for farmer who is difficult to sell his product farming. Partnership implementation by PT Simply Fresh Organic with organic vegetable farmer helps farmer in organic vegetable farming activity process. Such as, guarantee market which is available, capital assistance, development and production facilities by company that will help farmer to increase his income. The research aims to see: (1) Partnership pattern which is executed by PT Simply Fresh Organic with organic vegetable farmer, then will be seen category of partnership level relationship that is being intertwined. (2) To Analyze factors that influenced farmer is decision in partnership. The results of this research are: (1) Partnership pattern that is intertwined between PT Simply Fresh Organic with organic vegetable farmer is agribusiness operational partnership with degree of partnership in Prima Utama Partnership. (2) Factors which are significant or influential on farmer’s decision to partner are education factor and frequency of participating counseling.