bluuebunny/crossref_metadata_2025 huggingface dataset:
Treatment of Temporomandibular Disorder and Orofacial Pain in Unified Health System in Brazil
Authors: PMDC Reis
Published: January 2025

Objective: To evaluate the severity of pain in patients treated in the specialized care network for temporomandibular
disorders-related orofacial pain of Unified Health System (SUS) in the city of Belo Horizonte, Brazil, and characterize orofacial
pain based on the user profile, clinical aspects, and treatments performed.
Material and Methods: Research Diagnostic Criteria for Temporomandibular Disorders of patients were evaluated at the
Dental Specialty Center of Venda Nova region. Demographic data and clinical variables were collected. Descriptive and
bivariate analyses were performed using the chi-square (P < 0.05) and Kruskal-Wallis tests.
Results: The sample consisted of 169 users, 132 (78.1%) females, with a mean age of 43 (± 15.2) years. The most common
reasons for referral were pain (40.5%), followed by bruxism (25.6%) and temporomandibular joint disorders (24.4%). One
hundred twenty-one (71.6%) participants reported pain, of which 46.2% had mild/moderate pain and 25.4% had severe pain.
The most frequently reported diagnosis was disc displacement with reduction (DDR) (30.2%) followed by bruxism (24.9%).
The most indicated treatment was cognitive behavioral therapy (95.3%) followed by an intra-occlusal splint (IOS) (54.4%).
Conclusion: According to the results, women had a higher prevalence of pain, but no association was found between
comorbidities, age, and social vulnerability index.
KEMAMPUAN MENYELESAIKAN SOAL HOTS MATERI SISTEM PERSAMAAN LINEAR DUA VARIABEL DITINJAU DARI KEMAMPUAN NUMERASI SISWA KELAS VIII SMPN 2 LINGSAR TAHUN AJARAN 2023/2024
Authors: Rifka Diah Caesa Nanda  , Sripatmi  , Baidowi  , Sudi Prayitno
Published: January 2025

Penelitian ini bertujuan untuk mengkategorikan kemampuan numerasi dan mendeskripsikan kemampuan menyelesaikan soal HOTS ditinjau dari kemampuan numerasi siswa.  Penelitian ini termasuk dalam penelitian deskriptif dengan pendekatan kuantitatif dan kualitatif.  Populasi penelitian adalah seluruh siswa kelas VIII SMPN 2 Lingsar berjumlah 279 orang. Sampel penelitian adalah dua kelas dari sembilan kelas VIII yakni kelas VIII-6 dan VIII-8 yang diberikan tes kemampuan numerasi. Subjek penelitian diambil dari sampel yang terdiri dari 6 orang siswa yang diberikan tes soal HOTS. Metode pengumpulan data menggunakan metode tes dan wawancara dengan instrument penelitian yang digunakan adalah naskah soal kemampuan numerasi, naskah soal HOTS, dan pedoman wawancara. Teknik analisis data menggunakan analisis kuantitatif statistik deskriptif, uji korelasi dan uji t serta analisis miles dan huberman. Hasil penelitian menunjukkan bahwa kemampuan numerasi siswa dikategorikan ke dalam tiga kategori yakni tinggi, sedang, dan rendah.  siswa berkategori kemampuan numerasi tinggi,  siswa berkategori kemampuan numerasi sedang,  siswa berkategori kemampuan numereasi rendah dengan dominan kemampuan numerasi siswa berada pada kategori rendah. Terdapat hubungan kemampuan numerasi dengan kemampuan menyelesaikan soal HOTS siswa yang tergolong sangat kuat dan signifikan. Siswa dengan kemampuan numerasi tinggi mampu menguasai dan memenuhi indikator semua level HOTS. Siswa dengan kemampuan numerasi sedang dan rendah hanya mampu menguasai dan memenuhi indikator soal HOTS level menganalisis (C4) dan belum menguasai serta memenuhi indikator soal HOTS level mengevaluasi (C5) dan mencipta (C6).
Supplementing Systematic Review Findings With Healthcare System Data: Pilot Projects From the Agency for Healthcare Research and Quality Evidence-based Practice Center Program
Authors: Holmer Haley K. , Iyer Suchitra , Fiordalisi Celia , Kuhn Edi , Forte Mary , Murad M. Hassan , Wang Zhen , Tsou Amy Y. , Michel Jeremy J. , Umscheid Craig A.
Published: January 2025

Objectives. The Agency for Healthcare Research and Quality (AHRQ), through the Evidence-based Practice Center (EPC) Program, aims to provide health system decision makers with the highest-quality evidence to inform clinical decisions. However, limitations in the literature may lead to inconclusive findings in EPC systematic reviews (SRs). The EPC Program conducted pilot projects to understand the feasibility, benefits, and challenges of utilizing health system data to augment SR findings to support confidence in healthcare decision making based on real-world experiences.
Study Design and Setting. Three contractors (each an EPC located at a different health system) selected a recently completed systematic review conducted by their center and identified an evidence gap that electronic health record (EHR) data might address. All pilot project topics addressed clinical questions: infantile epilepsy, migraine, and hip fracture, respectively. EPCs also tracked additional resources needed to conduct supplemental analyses. The workgroup met monthly from 2022 to 2023 to discuss challenges and lessons learned from the pilot projects.
Results. Two supplemental data analyses filled an evidence gap identified in the systematic reviews (raised certainty of evidence, improved applicability), and the third filled a health system knowledge gap. Project challenges fell under three themes: regulatory and logistical issues, data collection and analysis, and interpretation and presentation of findings. Limited ability to capture key clinical variables given inconsistent or missing data within the EHR was a major limitation. Conducting supplemental data analysis alongside an SR added considerable time and resources to the review process (estimated total hours to complete pilot projects ranged from 283 to 595 across EPCs), and the increased effort and resources added limited incremental value.
Conclusion. Supplementing existing systematic reviews with analyses of EHR data is feasible, but resource intensive, and requires specialized skillsets throughout the process. While using EHR data for research has immense potential to generate real-world evidence and fill knowledge gaps, these data may not yet be ready for routine use alongside systematic reviews.
Pengaruh jenis Spesies Pillaring Agent Logam Si dalam proses Pilarisasi Bentonit Alam
Authors: Restu Kartiko Widi  , Emma Savitri
Published: January 2025

Abstract—The pillarization process of natural bentonite from Pacitan, East Java has been carried out using the metal species Si in Na-silicate and TEOS. The pillarization process is carried out using direct pillarization and indirect pillarization methods. In this research, the number of moles of metal pillaring agent used was 5 mmol/gram bentonite. The pillarization process is carried out by mixing the natural bentonite suspension and pillaring agent at a temperature of 80oC and stirring for 5 hours using a hot plate stirrer. Pillars were formed in the calcination and oxidation stages at a temperature of 500oC using N2 and O2 gas flows for 1 hour and 5 hours respectively. The resulting material was characterized using the FTIR spectroscopy method, X-ray diffraction and N2 gas adsorption using the BET method. The characterization results show that TEOS species can form better and more homogeneous pore structures compared to silicate species. The direct pillarization method provides better and more homogeneous pillar heights compared to the indirect pillarization method. However, the pore size obtained is still on the micropore size scale observed using the N2 gas adsorption method with the BET method.
Keywords: pillarization, si, teos, bentonite
 
Abstrak—Telah dilakukan proses pilarisasi bentonit alam asal Pacitan, Jawa Timur menggunakan spesies logam Si dalam Na-silikat dan TEOS. Proses pilarisasi yang dilakukan menggunakan metode pilarisasi langsung dan pilarisasi tidak langsung. Pada penelitian ini jumlah mol logam pillaring agent yang digunakan adlah 5 mmol/gram bentonit. Proses pilarisasi dilakukan dengan mencampurkan suspensi bentonit alam dan pillaring agent pada suhu 80oC dan diaduk selama 5 jam menggunakan hot plate stirrer. Pilar dibentuk pada tahap kalsinasi dan oksidasi pada suhu 500oC menggunakan aliran gas N2 dan O2 masing-masing selama 1 jam dan 5 jam. Material yang dihasilkan dikarakterisasi menggunakan metode spektroskopi FTIR, difraksi sinar-X dan adsorpsi gas N2 dengan metode BET. Hasil karakterisasi menunjukkan bahwa spesies TEOS dapat membentuk struktur pori lebih baik dan lebih homogen dibandingkan dengan spesies silikat. Metode plarisasi langsung memberikan tinggi pilar lebih baik dan lebih homogen dibandingkan dengan metode pilarisasi tidak langsung. Namun demikian ukuran pori yang diperoleh masih dalam skala ukuran mikropori yang diamati menggunakan metode adsorpsi gas N2 dengan metode BET.
Kata kunci: pilarisasi, si, teos, bentonit
EST-SSR based genetic diversity analysis and their tagging to coding and non-coding regions in Moringa oliefera
Authors: Narayana Poornima , Mandal Supriya , Shankar Raja , KV Ravishankar
Published: January 2025

Moringa oliefera is one of the most important vegetable tree crops with every part being important for commercial utilization with nutritional and medicinal properties. Development of genomic resources such as expressed sequence tag-based simple sequence repeat markers (EST-SSRs) are desirable due their multiallelic and polymorphic nature. In the present study, a total of 48 polymorphic EST-SSRs were mined from transcriptome data of different parts of Moringa plant. A set of 32 genotypes selected from the germplasmhave been assessed for diversity using these markers. The mean expected heterozygosity (HE) and observed heterozygosity (HO) was 0.827 and 0.990, respectively. The PIC value ranged from 0.511 to 0.94. While assigning function to the ESTs, one of the ESTs has been deciphered to contain a CTP. According to the peptide database, ESTs with EST-SSRs had similarity to PR genes and also showed presence of PlantCirc RNA. These developed EST-SSRs were tagged with different triats which can be useful in future population genetics analysis and breeding programs in Moringa species.
Los documentos de constitución de sociedades offshore en las Islas Vírgenes Británicas y su traducción al español: un enfoque contrastivo basado en el derecho comparado aplicado a la traducción
Authors: Aguilera María Presentación , CORPAS PASTOR GLORIA
Published: January 2025

La compleja trama fiscal que se desarrolla actualmente a nivel mundial ha propiciado un interés sin precedentes por la evasión fiscal global, como refleja el Informe sobre la Evasión Fiscal Global que ha elaborado el EU Tax Observatory del Parlamento Europeo en el 2024, lo cual ha repercutido, sin duda, en la traducción de textos jurídicos, socioeconómicos y financieros. Con frecuencia, los medios de comunicación difunden noticias sobre evasión fiscal en paraísos fiscales. Este ingente volumen de información de tipo socioeconómico genera también un importante volumen de negocio para la industria de la traducción. Concretamente, el presente estudio aborda la traducción de las denominadas sociedades offshore, con especial referencia a los aspectos terminológicos y sus equivalencias en español y en inglés. Desde un enfoque basado en el derecho comparado, nos centraremos en los documentos de constitución de tales sociedades en las Islas Vírgenes Británicas.
Dickinson en nuestra lengua: una galería de retratos
Authors: Alcaraz-Millán David
Published: January 2025

Reseña de Dickinson en nuestra lengua: una galería de retratos.Juan Carlos CalvilloCiudad de México, El Colegio de México, 2023, 200 pp.
Evaluation of Airport Buildings Against Terrorist Attacks in the Context of Architecture and Planning Criteria: Five Case Study
Authors: SARICIOĞLU Pelin , YILDIZ Aslı , SOYLUK Asena
Published: January 2025

Terrorist attacks are increasing worldwide with the impact of developing technologies and war tactics. One of the most common types of structures where these attacks are carried out is airport structures due to their international visibility and intense human circulation. Necessary precautions should be taken against possible terrorist attacks both in the planning and utilization process of airports. In this study, planning and architectural design criteria that can be taken against terrorist attacks are determined by utilizing literature data. Within the scope of these criteria, five airports were analyzed: Istanbul New Airport (IGA), Ankara Esenboğa Airport, İstanbul Sabiha Gökçen Airport, Antalya Airport, and Izmir Adnan Menderes Airport. In the selection of the buildings, the buildings with the largest passenger capacity in our country were preferred. As a result of the evaluations, the strengths, and weaknesses of the structures against terrorist attacks are presented in a table. According to the findings of the study, most of the airports are located in dense urban areas as a result of inaccurate predictions of urban growth and development. This makes these structures vulnerable to terrorist attacks. It was also found that perimeter walls do not provide sufficient visual and physical barriers at airports. Instead of concrete shear walls, most of the structures are secured with wire fences between concrete pillars. In conclusion, the planning and design of airports against possible explosions and terrorist attacks should be considered as a whole with its surroundings. Buildings should be evaluated as a whole with their land, and planning should be realized by taking into account the direction of urban growth and development.
Management Model for the Construction’s Waste Use in Walls Manufacturing
Authors: BIKS Yuriy , LIALIUK Olena , ZERONG Wan , LIALIUK Andrii
Published: January 2025

The mathematical model, which could be represented as a fuzzy inference tree for project man-agement aimed at waste usage in wall manufacturing, is proposed in the article. The factors classification that affect production's environmental and economic efficiency is presented. The proposed ecological and economic efficiency criterion and influence factors are linguistic variables consisting of fuzzy terms on the corresponding universal sets. The proposed hierarchical system of mathematical models allows the intelligent choice of proper building material, depending on the influence of environmental parameters, socio-economic parameters, and engineering and technological parameters of a building object, based on fuzzy logical expressions “IF-THEN”. The proposed model could be used as a support system model in the decision-making process at the early feasibility stage. Estimating pros and cons based on the results of a virtual experiment in terms of proposed criterion value for specific construction waste allows proper planning of construction waste usage in the construction sector. The proposed model can be used as a design and engineering tool in the decision-making process for forecasting the ecological and economic efficiency of the use of waste in the manufacture of walls.
UNAPREĐENJE SKLADIŠNOG POSLOVANJA U ORGANIZACIJI „NUOVO ARTE“
Authors: Vidović Jovana
Published: January 2025

Cilj ovog rada je projektovanje mera unapređenja skladišnog poslovanja u preduzeću kako bi se postigla viša efikasnost i efektivnost u radu i poslovanju. Rad sadrži teorijski i praktični deo procesa unapređenja, ali i predlog mera unapređenja.
ANALIZA LOJALNOSTI KUPACA: STUDIJA SLUČAJA KANADSKOG BRENDA THE ORDINARY
Authors: Tošić Valentina
Published: January 2025

Cilj rada jeste da se analizira nivo zadovoljstva i lojalnosti kupaca kanadskom brendu The Ordinary. Kroz analizu ponašanja potrošača i načina na koji donose odluke u cilju stvaranja veće baze lojalnih kupaca za kanadski brend The Odrinary, biće istaknuti najznačajniji faktori koji utiču na stvaranje lojalnosti. Primarno istraživanje obuhvata uzorak korisnika na tržištu Srbije, a rezultati su upoređeni sa marketinškim komunikacijama ovog brenda na kanadskom tržištu.
DETEKCIJA HEPATITIS C VIRUSA: ULOGA AUTOMATIZOVANIH SISTEMA U LABORATORIJAMA ZA MOLEKULARNU DIJAGNOSTIKU
Authors: Galić Kasandra
Published: January 2025

Ovaj rad se fokusira na analizu uloge automatizovanih PCR sistema u dijagnostici hepatitisa C virusa (HCV) u kliničkim laboratorijama. Istražićemo osnovne principe PCR metodologije, korake pripreme uzoraka, kao i prednosti koje automatizovani sistemi donose u dijagnostičkim procedurama. Takođe, biće prikazani rezultati analize uzoraka pacijenata, uz diskusiju o mogućim strategijama za unapređenje dijagnostičke prakse. Cilj rada jeste doprineti boljem razumevanju i primeni savremenih tehnologija u dijagnostici HCV-a.
LIDOCAINE -AN OLD DRUG FOR NEW INDICATION
Authors: Nandha Ruchika
Published: January 2025

Lidocaine, a known local anaesthetic agent has been demonstrated to possess significant efficacy in managing asthma due to its anti inflammatory and direct spasmolytic actions. Various clinical studies have been conducted to assess the role of Lidocaine in asthma management with convincing results showing reduction in steroid dose or discontinuation of steroid therapy associated with improvement in quality of life, marking this old drug as a novel efficacious, fast and safe addition in armamentarium of anti asthma drugs. Inhaled Lidocaine when given alone causes biphasic effect on bronchi with initial bronchoconstriction followed by bronchodilatation. Treatment with combination inhalers, containing Lidocaine and a long-acting β2- agonist seems the safer and more reliable alternative to minimise adverse effects of initial reflex bronchoconstriction caused by inhaled Lidocaine. This review elucidates the available evidence on efficacy and safety of inhaled Lidocaine after analyzing various clinical studies. Searches of pubmed, Cochrane database, Medscape, Google and clinicaltrial.org were made for terms like Lidocaine and bronchial asthma.
DOCKING STUDIES OF PLANT POLYPHENOLS WITH AΒ FRAGMENTS SUGGESTS DETERMINANTS THAT ENABLE DESIGN OF INHIBITORS TOWARDS PREVENTING AGGREGATION EVENTS DURING ALZHEIMER’S
Authors: Shruthila N. , Narayan Priya , Kumar D. Jagadeesh , Nagendra H. G.
Published: January 2025

The aggregation of Amyloid beta peptides is considered as one of the causative events in the pathogenesis of Alzheimer’s disease (AD). Polyphenols present in different plant sources, which have acclaimed therapeutic values, are known to inhibit the formation of Amyloid fibrils. Hence, docking studies with different polyphenols were carried out to appreciate their binding modes and plausible molecular interactions. The results reveal a consensus pattern of association, exhibiting that all the ligands preferentially dock to the metal coordinating residues in the peptide fragments. In fact, the metal interacting geometries in the Aβ segments are known to be implicated in aggregation events. Further, due to non-specific binding, these polyphenols are expected to have a competitive inhibitory efficacy over a range of amyloid peptide fragments. Thus, these findings suggest that the polyphenolic compounds could become promising lead molecules that aid in the development of inhibitors and neuroprotectors towards prevention of amyloid fibril formations and AD.
HEPATOPROTECTIVE ACTIVITY OF HERBAL PREPARATION (HP-4) AGAINST D-GALACTOSAMINE INDUCED HEPATOTOXICITY IN MICE
Authors: Padmanabhan P. , Jangle S. N.
Published: January 2025

Oxidative stress in mammals results from imbalance between generation of free radicals and the rate of their suppression by antioxidant. Hepatotoxicity may result as an effect of excessive free radical formation due to exogenous chemicals or metabolic reactions. D-Galactosamine (D-GalN) is a well known hepatotoxicant. Herbal medicines have been utilized to manage hepatotoxicity according to recent trends. In the present study Herbal Preparation or HP-4 is a combination of 80% alcoholic extract of leaves of Aloe vera, Bacopa monniera, Moringa oleifera and rhizome of Zingiber officinale has been utilized to study its efficacy on mice model of D-GalN hepatotoxicity. D-GalN hepatotoxicity induces liver injury closely resembling human viral hepatitis with necrosis, inflammation and regeneration. Evidenced by biochemical and histopathological studies it is concluded that polyherbal formulation HP-4 offered a synergistic protection due to the phytochemicals present which provide hepatoprotective activity induced by D-GalN hepatotoxicity.
ANTIULCER ACTIVITY OF ETHANOLIC EXTRACT OF TERMINALIA CATAPPA LEAVES AGAINST GASTRIC ULCERS BY PYROLIC LIGATION INDUCED MODEL IN RATS
Authors: G Bharath Kumar , Kumari Divya , G Sravanthi , G Rajeshwar , V Umadevi , Kotla Niranjan Goud
Published: January 2025

Terminalia catappa family combretaceae moreover known as Indian almond was a large, spreading tree scattered throughout the tropics in coastal environments in India. Anti-ulcer activity of ethanolic extract of T. catappa (250 and 500 mg/kg b.w) was examined on pyrolic ligated induced ulcer model in rats. Omeprazole was used as standard. The anti-ulcer activity of T. catappa was evaluated with the help of ulcer index and histopathological examination. Preliminary phytochemical screening and acute toxicity studies of T. catappa also carried out. The extract showed significant (p < 0.001) reduction in pH, gastric volume, free acidity, total acidity and ulcer index in dose dependent manner as compared to control. The extract did not produce any toxic effects even at high doses. The anti-ulcer activity was probably due to the presence of flavonoids.
SYNTHESIS, CHARACTERIZATION AND ANTIBACTERIAL EVALUATION OF SOME POTENT 2-SUBSTITUTED BENZIMIDAZOLE ANALOGUES
Authors: Rao K. Govinda , Chakraborty Dipankar
Published: January 2025

Present study circumspects synthesis of some novel 2-substituted analogues of Benzimidazole and their spectral characterization by means of UV, IR and 1H NMR. The compounds were screened for antibacterial activity against standard strains of both Gram positive and Gram negative bacteria. Results obtained establish compounds KD1 and KD2 to be significantly responsive against different bacterial strains and as such these compounds can pave the way for development of potent antibacterial agents.
HEPATOPROTECTIVE EFFECT OF WATTAKAKA VOLUBILIS EXTRACT ON ALUMINIUM SULPHATE INDUCED LIVER TOXICITY
Authors: Rani S. Usha , Chitra M. , Jainu Mallika
Published: January 2025

Wattakaka volubilis (Linn) is used as a phytomedicine for liver diseases. In the present study the effect of methanolic extract of Wattakaka volubilis powder was carried out against the Aluminium toxicity in rat model. Various doses of Wattakaka volubilis extract (100, 200, 400 mg/kg/b.w) was given orally for 30 days to Aluminum sulphate toxicity exposed rats. They were observed each hour for 24 h and each day for 30 days for any changes in behavioural activity and mortality. Clinical observation, body weight, organ weight, biochemical enzymatic analysis and histological examination were carried out. The extract was found to possess hepatoprotective activity in a dose dependent manner and the effect was comparable with silymarin, a standard drug. The extract significantly reduce the toxicity of Aluminium sulphate caused in liver due to the presence of phytoconstituents such as alkaloids, sterols, tannins, triterpenoids and flavonoids which are known hepatoprotectant.
ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACTS OF LEAF AND STEM BARK OF CALOPHYLLUM INOPHYLLUM ON ALBINO WISTAR RATS
Authors: Baig Mirza Danish , Basheeruddin Syed , S. Silpa , Reddy A. Venkateshwara
Published: January 2025

The aim of the present study was to conduct phytochemical screening, perform acute oral toxicity effect and to evaluate the anti-inflammatory effect of ethanolic extracts of leaf and stem bark of Calophyllum inophyllum on albino Wistar rats. Carrageenan induced paw edema and cotton pellet granuloma techniques were applied to determine anti-inflammatory properties of the extracts. Extracts were administered orally. Acute oral toxicity studies were conducted using the OECD guidelines 423 Annexure – 2d. The results indicate the mortality was not observed during the toxicity studies and maximum safe does was determined. The anti-inflammatory effect of the extracts showed significant dose dependent effect (200 mg/kg b.w and 400 mg/kg b.w) on both acute and chronic models of inflammation i.e., carrageenan induced paw edema and cotton pellet granuloma respectively. Additionally, Calophyllum inophyllum leaves extract showed more activity compared to Calophyllum inophyllum stem bark extract.
ANTIOXIDANT EFFECT OF GARCINIA INDICA LINN FRUIT EXTRACT AGAINST ISOPRENALINE HYDROCHLORIDE INDUCED MYOCARDIAL NECROSIS IN RATS
Authors: Kumar V. Dhana Rangesh , Gurusamy K.
Published: January 2025

The present study was designed to investigate the antioxidant effect of Garcinia indica Linn fruit extract on heart weight, lipid peroxidation; enzymatic and non-enzymatic antioxidants against isoprenaline hydrochloride (ISO) induced myocardial infarction (MI) in rats. Group II rats treated with Isoprinosine (25 mg/kg. b.w. i.p.) recorded significant (p<0.05) increase in heart weight and cardiac lipid peroxidation whereas there was significant decrease in enzymatic and non-enzymatic antioxidants. Pretreatment with Garcinia indica fruit extract (250 mg/kg b.w and 500 mg/kg b.w. per day/p.o.) for 30 consecutive days followed by ISO injections on 29th and 30th days in group III and IV rats showed that significant decrease in heart weight and cardiac lipid peroxidation where as the enzymatic antioxidant and nonenzymatic activities, were significantly increased when compared to ISO treated group II. Hence, the present study suggested that the fruit extract of Garcinia indica was effective as cardioprotective and antioxidant agent.
QUANTITATIVE DETERMINATION OF MIFEPRISTONE IN PHARMACEUTICAL SAMPLES BY, VISIBLE SPECTROPHOTOMETRIC METHOD USING CE (IV) AS AN ANALYTICAL REAGENT
Authors: Giri A. , Saritha B. , Reddy B. Vijayabhaskara , Reddy T. Sreenivasulu
Published: January 2025

A simple, sensitive and accurate visible spectrophotometric method has been developed for the assay of mifepristone. The method is based on the colour reaction between Ce (IV) and mifepristone in the pH range 1.0-5.0.The golden yellow coloured complex is exploited for the development of a visible spectrophotometric procedure for the determination of mifepristone. The absorption spectrum of the complex shows maximum absorbance at 430nm at pH 2.0. Beer’s law is obeyed in the range 1.5-30.0 µg/ml of mifepristone. The molar absorptivity and sandell’s sensitivity are 1.714×104 l mol-1 cm-1 and 0.0251µg cm-2 respectively. The standard deviation of the method for ten determinations of 10 µg/ml mifepristone is 0.0013. The correlation coefficient () of the experimental data of the calibration plot is 0.9999. The proposed spectrophotometric method was validated according to ICH specifications. The validation parameters such as, linearity, accuracy, precision, LOD, LOQ and ruggedness were studied. The method for the quantitative assay of mifepristone was successfully applied for its assay in pharmaceutical formulations.
FABRICATION AND CHARACTERIZATION OF CEFOPODOXIME PROXETIL SOLID DISPERSION FOR SOLUBILITY ENHANCEMENT
Authors: Gupta Sushma , Munjal Tania , Kaur Amanjot , Bagga Kamaljeet S
Published: January 2025

Cefopodoxime Proxetil belongs to BCS class IV and used in treatment of upper respiratory tract and urinary tract infections. Solid dispersions (SDs) are one of the most promising strategies to improve the solubility, dissolution and ultimately oral bioavailability of such poorly water soluble drugs. The main objective of the present research was to formulate Cefopodoxime Proxetil solid dispersion employing two methods namely hot melt granulation and solvent evaporation method. The PEG 4000 and PEG 6000 were used as carrier in varied proportion (1:1, 1:2, 1:3 and 1:4 w/w). Results of FT-IR spectra revealed no potential chemical incompatibility between drug and excipients. Enhancement in the percent drug released and dissolution rate was observed in SD of PEG 6000 as to PEG 4000 and pure drug. Drug release kinetics studies revealed that the drug release from the formulations followed non-fickian diffusion and the best fitted model for drug release for Korsmeyer Peppas Model. No sharp peaks were observed in both solid dispersions (comprising PEG 4000 & PEG 6000) in PXRD spectra revealing the formation of amorphous product. Similar results were observed in DSC studies indicating disappearance of sharp fusion endothermic peak i.e. conversion of crystalline form into amorphous form. These results were further supported by SEM studies showing disappearance of crystal habit in these formulations.
NEW STABILITY-INDICATING RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR THE DETERMINATION OF ROSUVASTATIN (CALCIUM) IN PHARMACEUTICAL DOSAGE FORMS
Authors: N Usha Rani , Ankani Nagoor
Published: January 2025

A stability indicating, accurate, specific, linear and sensitive reverse phase-HPLC method was developed and validated for the determination of Rosuvastatin calcium (ROS) in pharmaceutical dosage form. The chromatographic separation was performed using Eclipse XDB plus C18 Column (4.6 × 150 mm, 5μm particle size). Mobile phase was made by using Acetonitrile: Water (60:40 v/v) at a flow rate of 1.0 ml/min with the detection wavelength at 242 nm. The retention time of ROS was found to be about 1.787 min. The linearity was obtained in the concentration range of 10-50 μg/ml with a correlation coefficient of 0.999. The percentage purity of ROS was found to be 100.06 %. The percentage recovery was determined for ROS and found to be 100.53 %. The developed analytical method was validated for linearity, precision, accuracy, ruggedness, robustness, specificity and system suitability which were within the acceptance limit according to ICH guidelines. All the degradation products obtained by stress conditions were found to be well separated from the principal peak, which means that the ROS peaks were highly pure in all chromatograms obtained. The developed method was found to be applicable for routine quality control and stability analysis of ROS in pharmaceutical dosage forms.
DEVELOPMENT AND CHARACTERIZATION OF HYDROXYL CHLOROQUINE SULPHATE (HCQ) NANOPARTICLES
Authors: . Roopkishora , Singh Amit , Singh Chhote Lal
Published: January 2025

The objective of present study was to formulate and characterize the nanoparticles of hydroxyl chloroquine sulphate (HCQ). Nanoparticles were prepared by the w/o/w emulsion - solvent evaporation method using polymer Eudragit® RL-100, acetone, and surfactant poloxmer-188 solutions. Amount of polymer, organic solvent and surfactant was selected as formulation variable. Characterization of the nanoparticles was performed by measuring particle size, zeta potential, surface morphology, interactions, drug entrapment efficiency, in-vitro drug release, % yield and stability. The formulated nanoparticles were found to be spherical and uniform in particle size with less than one poly dispersity index. The zeta potential of nanoparticles was found -34 (mv) represent higher stability of colloidal dispersion. In another set of characterization the percentage yield and entrapment was found to be in the range of 55-68% and 63.14% respectively. The in-vitro release shows 87.93% at its maximum level in 24 hours of study. The suspension of formulation was found more stable in refrigerated environment. The release kinetics evaluation revealed the drug release was following Higuchi model, which ensures the possibility of long term release profile from the nanoparticles formulation so that its concentration maintained within therapeutic level for larger period of time so that safe and efficacious for malarial and rheumatoid patients.
IDENTIFICATION OF ARYLTETRALIN LIGNANS FROM PODOPHYLLUM HEXANDRUM USING HYPHENATED TECHNIQUES
Authors: Sharma Ekta , Arora Bhupinder Singh
Published: January 2025

In the present study, with the appliance of hyphenated techniques involving high performance liquid chromatography with diode array detection directly coupled with 1H nuclear magnetic resonance spectroscopy (LC-NMR) and electrospray ionization mass spectrometry (LC-ESI-MS), four known aryltetrahydronephthalene lignans (podophyllotoxin 4-O-glucopyranoside, 4’-demethylpodophyllotoxin, podophyllotxin and dehydropodophyllotoxin) have been well characterized from methanol extract of rhizomes of Podophyllum hexandrum Royle without involving the time consuming steps of isolation and purification of individual constituents of the extract. Also, a simple, sensitive and reproducible LC-MS method has been developed for the quantitative analysis of podophyllotoxin in crude methanolic extract from different parts of Podophyllum hexandrum Royle. The present work adds up to the existing significance of hyphenated techniques combining chromatographic technologies with spectroscopic techniques for both qualitative and quantitative analysis of natural product extracts or fractions without any need of reference standards for the markers.
Can the Tenure of the Government of National Unity Enhance Public Accountability in the South African Government? (2024-2029)
Authors: Thusi Xolani
Published: January 2025

The South African government has struggled with public accountability over the past 30 years of democracy. The government has been dominated by the African National Congress (ANC) for 30 years, and this dominance has not enhanced public accountability but has made it worse. It cannot be argued that the government led by ANC has made many strides in advancing the lives of the marginalised people through progressive policies that were designed to address the wrongs made by the apartheid government. Overtime the government led by ANC abandon it principles and values and this is evident as this government high ranking political office bears were mostly caught up in corruption scandals. The state capture masterminds were mostly affiliated with the ANC, and this shows a lack of public accountability, and the bunts are mostly felt by the marginalised people. As the lack of public skyrocketed all spheres and entities of South Africa government this led to poor public service delivery across the public sector. The lack of public service delivery is evident in South African government as service delivery protest takes place more often mostly in the local government sphere which is closer to the people. This paper analysed the prospects of the GNU in enhancing public accountability in South African public sector. The author is of the view that the GNU has the potential to enhance public accountability and service delivery in South Africa, due to diverse political parties working together in cabinet and in the parliament. A desktop approach was used to review recent literature on the phenomenon.
LA PEDAGOGÍA DE PAULO FREIRE: UNA FUENTE DE INSPIRACIÓN PARA UNA PROPUESTA DE EDUCACIÓN INTERCULTURAL
Authors: Verdeja Muñiz Maria
Published: January 2025

Presentamos una reflexión en torno a diversas aportaciones de la pedagogía de Paulo Freire (1921-1997) y ponemos de manifiesto la actualidad de sus planteamientos pedagógicos. Freire fue una persona que tuvo una especial preocupación por el otro, por denunciar las injusticias y por mostrarnos que los seres humanos tenemos en nuestras manos las posibilidades del cambio y de la transformación. Tal vez, por estos motivos, encontramos en el educador brasileño un referente clave a la hora de plantear y diseñar propuestas pedagógicas de educación en contextos educativos multiculturales. Inspirados en las aportaciones de su pedagogía, presentamos lo que consideramos unas líneas clave que deberían integrar una propuesta de educación intercultural.
EXPLORANDO LA(S) INFANCIA(S) DE LA MANO DE LOS NIÑOS, NIÑAS Y ADOLESCENTES GUAYAQUILEÑOS
Authors: Uribe Lotero Claudia Patricia , Vallejo Robalino Diana , Luzuriaga Uribe Estefanía
Published: January 2025

El presente artículo tiene por objetivo describir las comprensiones acerca de las infancias y su entorno desde los niños, niñas y adolescentes (NNA) y desde las organizaciones de la sociedad civil vinculadas a los servicios de protección especial en Guayaquil. Para aproximarse a un diagnóstico integral, se realizaron talleres de dibujo con niños, niñas y adolescentes de la ciudad, así como sesiones de trabajo con 25 ONGs que trabajan por la protección y garantía de derechos de los NNA. Se visibilizó que los NNA tienen plena conciencia de las problemáticas que los aquejan y se presentaron temáticas que tienen potencial para realizar planes de acción que integren a todos los actores involucrados en la protección especial de las infancias.
POLÍTICAS PÚBLICAS DE EDUCACIÓN INFANTIL EN CHILE Y BRASIL: TENSIONES Y TENDENCIAS SOBRE CALIDAD Y GESTIÓN LOCAL
Authors: Monje Marín Jennifer
Published: January 2025

Este artículo tiene por objetivo socializar los resultados de un estudio sobre políticas de Educación Infantil (EI) en dos países sudamericanos, realizado como tesis para la obtención del grado de Maestría en Educación. Fundamentada en el campo de la Educación Comparada, la investigación describió y comparó la configuración de políticas públicas de EI de Chile y Brasil, a partir del análisis documental, la revisión de investigaciones nacionales y la voz de los gestores, para comprender las tensiones y tendencias sobre calidad y gestión local. Las conclusiones muestran que existe una convivencia difusa entre los discursos de las políticas de calidad y las acciones tomadas para su implementación local en los dos países. Además, se destaca la tendencia de las actuales reformas, orientadas hacia la búsqueda de un equilibrio entre estandarización y contextualización que propicie una renovada imagen de las instituciones como factores de calidad y transforme el sistema.
LAS EVALUACIONES ESTANDARIZADAS COMO CONDICIONANTES DE LA ACCIÓN DIDÁCTICA
Authors: Ferrando Miriam Andrea
Published: January 2025

El presente artículo indaga sobre las interpretaciones que docentes de primer año básico realizan al analizar una secuencia didáctica, con el objetivo de comprender la construcción del conocimiento didáctico de profesores de enseñanza básica en alfabetización inicial. El estudio formó parte de una investigación cualitativa realizada en Santiago de Chile en tres escuelas subvencionadas de la Región Metropolitana. El material analizado corresponde a entrevistas individuales, sesiones de trabajo de análisis de la secuencia didáctica y reflexión de lo realizado, observaciones de clases y acompañamiento en sala. Los hallazgos indican que las evaluaciones estandarizadas actúan como condicionantes de la acción didáctica. Los docentes consideran que estas mediciones ocupan un lugar privilegiado respecto de las prácticas en alfabetización inicial.
EDUCACIÓN DE JÓVENES DESESCOLARIZADOS EN EL SALVADOR: ENTRE EL TEMOR Y LA ESPERANZA
Authors: San Martín Ramírez Víctor
Published: January 2025

Este artículo tiene como objetivo describir los principales desafíos que enfrenta El Salvador en materia de políticas educativas, especialmente las que han sido diseñadas para contrarrestar las altas tasas de abandono o deserción escolar, y la recaptura de la población de jóvenes que podrían retomar sus estudios para obtener su Bachillerato (Enseñanza Secundaria completa) y, a la vez, dotarse de mayores y mejores herramientas para enfrentar el futuro con alguna calificación ocupacional o laboral. Se describe la situación social, económica y educacional del país y también de su entorno internacional, y se muestra parte de la arquitectura general del rediseño curricular, de gestión y financiamiento para las denominadas Modalidades Flexibles (en adelante MF), una alternativa a la educación regular, para aumentar su cobertura. Las MF nacen con el Plan de Educación 2021 (del año 2005), pero no ha logrado los resultados esperados, especialmente en cobertura y calidad. El Proyecto ECYP (Education for Children and Young Project) tiene entre sus objetivos rediseñar y actualizar las MF para ampliar significativamente su, hasta ahora, escasa cobertura y calidad, agregándole, además, los componentes de habilidades para la vida y una formación técnico-laboral para el ingreso de los estudiantes al mercado laboral si así lo prefieren. El autor de este artículo descriptivo se desempeña actualmente, en cuanto consultor internacional, como coordinador del proyecto de rediseño del currículo, el financiamiento y la gestión de las MF, un proyecto financiado por la Agencia de los Estados Unidos para el Desarrollo Internacional (USAID), a través de la Fundación para la Educación Integral Salvadoreña (FEDISAL).
O CURRICULO ESCOLAR E OS FUNDAMENTOS TEÓRICOS DA PEDAGOGIA HISTÓRICO-CRÍTICA NO BRASIL
Authors: Malanchen Julia , Trindade Zank Debora Cristini
Published: January 2025

Neste artigo, apresentamos os principais elementos teóricos que fundamentam a perspectiva dialética e materialista da Pedagogia Histórico-Crítica. Destacamos que esta teoria pedagógica, que hoje é construída coletivamente no Brasil, tem como primeiro formulador o professor Dermeval Saviani, que no final da década de 1970 escreve a primeiras produções sobre esta teoria. Iniciamos realizando uma exposição da gênese da pedagogia histórico-crítica e na sequência expomos as concepções de educação, trabalho educativo e currículo escolar. Finalizamos, o trabalho, apontando a pedagogia histórico-crítica como uma pedagogia socialista que compreende a escola como espaço de contradição e, portanto que produz emancipação e também alienação.
Las Aporías de la Calidad Educativa: La confusa respuesta a la crisis educativa en el mundo
Authors: Guzmán Marín Francisco
Published: January 2025

El presente artículo es un informe parcial de una investigación más amplia sobre la calidad educativa y la evaluación docente, cuyo objetivo central es reconstruir las principales tendencias, estrategias y problemáticas que enfrentan estas dos acciones globales. En el estudio de la calidad educativa se utilizó el método hermenéutico-genealógico de corte nietzscheano-foucaultiano, para reconocer la fuente de procedencia y la emergencia histórica que posibilita su imperativa instauración en los sistemas educativos contemporáneos.Los principales hallazgos son: la ambigüedad del concepto, el carácter prescriptivo de sus criterios y la deformación de las prácticas socio-educativas que ha comportado su acrítico seguimiento. Al nal, la consecuencia principal de la instauración de los dispositivos de la calidad en la educación, es el arraigo de la cultura de la Pedagogía del Examen.
¿Concientización o Domesticación? Leyendo Estaba La Pájara Pinta Sentada En El Verde Limón desde la perspectiva política y educativa de Paulo Freire
Authors: Nieto Angel Maria Carolina
Published: January 2025

Este artículo considera el libro de Albalucía Ángel Estaba la pájara pinta sentada en elverde limón a través del concepto de concientización (conscientização) propuesto porPaulo Freire. El libro está ambientado en el período conocido como La Violencia, acontecidoa mediados del siglo XX en Colombia. Se argumenta que la polifonía de personajesen el libro representa aspectos de un proceso continuo pero frágil de concientización.En medio de la diversidad de perspectivas y voces simultáneas, se destaca la voz de unaniña de clase media alta que problematiza las condiciones opresivas del mundo dondevive. Este personaje representa la necesidad insatisfecha de una educación liberadora y laperpetuación de lo que Freire denominaba domesticación. Además, se argumenta quela polifonía en esta novela no es solo un estilo literario, sino un posicionamiento políticodeliberado, que Ángel asume, sobre las posibilidades de la concientización colectiva.Palabras clave: Paulo Freire, Albalucía Ángel, concientización, educación.
Un día en la vida de docente y estudiante virtual
Authors: Nardelli Maximiliano , Garelli Fernando Miguel , López Pablo , Mengascini Adriana
Published: January 2025

En este trabajo presentamos un análisis de narraciones elaboradas por un grupo de residentes de dos profesorados universitarios de Argentina durante el primer semestre de 2020. Como equipo a cargo de las Prácticas Docentes nos posicionamos político-pedagógicamente desde la Educación Popular Latinoamericana, apuntando a la formación de profesionales reflexivos/as, que puedan desarrollar una mirada crítica. En los inicios del periodo de aislamiento por Covid-19, hemos solicitado la realización de narraciones autobiográficas, viendo que la participación venía con dificultades y angustias. A partir de esas narraciones, elaboramos este análisis centrando la mirada sobre las vivencias y los sentires de ese grupo de estudiantes, cuya mayoría se desempeñaba ya como docentes. Miedo, cansancio, frustración, incertidumbre, problemas técnicos, cambios en la cotidianidad, aparecen fuertemente en estas producciones. Asimismo, advertimos que durante el periodo de aislamiento, virtualización de las propuestas educativas y teletrabajo, los cuerpos fueron “recortados y expulsados de la situación educativa”, los lazos afectivos fueron fragmentados y se agudizó la individualización de la tarea docente.
Políticas educativas y el sector privado en Chile 1980-2020:
Authors: Carrasco Juan Antonio
Published: January 2025

A partir del año 2015, Chile impulsa una política orientada a regular el sector de escuelas privadas subvencionadas por el Estado. Para este propósito, la reforma iniciada centraliza los procesos de admisión, prohíbe el ánimo lucrativo y reemplaza el cobro obligatorio a las familias, buscando elevar los niveles de equidad y mixtura social del sistema educativo. El presente articulo analiza los cambios en el contexto y trayectoria de política educativa a partir de su vínculo con el sector privado. Para la caracterización del ciclo de política educativa se realizó una revisión de literatura, se analizó la historia legislativa y se utilizó un modelo basado en la construcción tipológica de contextos regulatorios para el sector privado subvencionados de escuelas. Entre los principales resultados, destaca que este ciclo reciente articula un nuevo marco para el sector privado subvencionado transitando desde un contexto de mercado desregulado a uno donde la política educativa equilibra los tipos de provisión a partir de una ‘elección controlada’ y nuevos elementos de planificación educacional.
La obra de un pedagogo social
Authors: Medina Borges Rosa María
Published: January 2025

Siendo muy joven José Martí sufre prisión. No obstante ser hijo de españoles, ya soñaba a Cuba como patria independiente. El presente artículo aborda su terrible vivencia, que publicara bajo el título: El Presidio Político en Cuba. Constituye una invitación a la opinión pública española de la época a conocer que sucedía en Cuba, a sentir empatía por los seres humanos que sufrían. Era su interés develar todos los aspectos del crimen, para que fuera el pueblo español un agente más de lucha contra semejante injusticia. La obra marca su maduración ideológica y política en ascenso. Analiza la realidad con un lenguaje metafórico extremadamente complejo y diverso en géneros literarios.  Realizamos una revisión de bibliografías que abordan los aspectos relacionados con el enfoque histórico y literario del mencionado trabajo martiano. Ninguno integra todos esos elementos con las patologías médicas de los presos que lo acompañaron durante su condena. Se utilizó como metodología el análisis literario de los textos para develar la postura pedagógica martiana, que perseguía el logro del compromiso social y humano del pueblo español hacia el pueblo cubano, poseedor de los mismos derechos de justicia que enarbolaban los republicanos ibéricos
Un Tiempo para la esperanza
Authors: Murua Alejandro Ezequiel
Published: January 2025

El presente ensayo pretende repensar a la pedagogía crítica en el actual escenario neoliberal, con el objetivo de comenzar a prevenir una catástrofe política, epistemológica y ecológica. En un primer momento, se definirán las características del presente estado crítico. En un segundo momento, se postularán dos principios a los fines de problematizar las condiciones actuales de la sociedad y de la educación, sostenidos en un posicionamiento docente que reivindique lo inutilidad de ciertos saberes escolares y la proyección de postulados utópicos. Finalmente, en la conclusión se recuperará la problematización del desarrollo y se postularán algunas preguntas que pretenderán guiar el decurso de la investigación y la reflexión junto a otros.