bluuebunny/crossref_metadata_2025 huggingface dataset:
Desmoid Tumors Characteristics, Clinical Management, Active Surveillance, and Description of Our FAP Case Series
Authors: Sanchez-Mete Lupe , Ferraresi Virginia , Caterino Mauro , Martayan Aline , Terrenato Irene , Mannisi Elena , Stigliano Vittoria
Published: December 2020

(1) Background: desmoid tumors (DTs) are common in patients with familial adenomatous polyposis (FAP). An active surveillance approach has been recently proposed as a valuable alternative to immediate treatment in some patients. However, no clear indication exists on which patients are suitable for active surveillance, how to establish the cut-off for an active treatment, and which imaging technique or predictive factors should be used during the surveillance period. (2) Results: we retrospectively analyzed 13 FAP patients with DTs. A surveillance protocol consisting of scheduled follow-up evaluations depending on tumor location and tissue thickening, abdominal computed tomography (CT) scan/Magnetic resonance imaging (MRI) allowed prompt intervention in 3/11 aggressive intra-abdominal DTs, while sparing further interventions in the remaining cases, despite worrisome features detected in three patients. Moreover, we identified a possible predictive marker of tumor aggressiveness, i.e., the “average monthly growth rate” (AMGR), which could distinguish patients with very aggressive/life-threatening tumor behavior (AMGR > 0.5) who need immediate active treatment, from those with stable DTs (AMGR < 0.1) in whom follow-up assessments could be delayed. (3) Conclusion: surveillance protocols may be a useful approach for DTs. Further studies on larger series are needed to confirm the usefulness of periodic CT scan/MRI and the value of AMGR as a prognostic tool to guide treatment strategies.
Short-Term Outcomes of Surgery for Graves’ Disease in Germany
Authors: Maurer Elisabeth , Vorländer Christian , Zielke Andreas , Dotzenrath Cornelia , von Frankenberg Moritz , Köhler Hinrich , Lorenz Kerstin , Weber Theresia , Jähne Joachim , Hammer Antonia , Böttcher Knut A. , Schwarz Katharina , Klinger Carsten , Buhr Heinz J. , Bartsch Detlef K.
Published: December 2020

Background: Surgical treatment of Graves’ disease (GD) has a potentially increased incidence of postoperative hypoparathyroidism, recurrent laryngeal nerve palsy (RLNP) and bleeding. The aim of this study was to evaluate the current extent of surgery for the treatment of GD and its safety as a short-term outcome. Methods: Patients who underwent thyroid resection for GD were identified from the prospective StuDoQ/Thyroid registry. Patient data were retrospectively analyzed regarding demographics, surgical procedures and perioperative outcomes. Statistics were performed with Student’s t-test or Fisher’s exact test and multivariate Cox regression analysis. The level of statistical significance was set at p < 0.05. Results: A total of 1808 patients with GD with a median age of 44 (range 14–85) years were enrolled in a 25-month period by 78 departments, of which 35.7% (n = 645) had an endocrine orbitopathy and 0.1% (n = 6) had thyrotoxic crisis. Conventional open surgery was used in 98.6% of cases and minimally invasive or remote-access approaches were used in 1.4%. Total thyroidectomy was performed in 93.4% of cases (n = 1688). Intraoperative neuromonitoring (IONM) was used in 98.9% (n = 1789) of procedures. In 98.3% (n = 1777) at least one parathyroid gland was visualized and in 20.7% (n = 375) parathyroids were autografted. The rates of unilateral and bilateral transient RLNP were 3.9% (n = 134/3429 nerves at risk) and 0.1% (n = 4/3429 NAR). The rates of transient RLNP tended to be higher when intermittent IONM was used compared to continuous IONM (4.1% vs. 3.4%, p < 0.059). The rate of transient postoperative hypoparathyroidism was overall 29% (n = 525/1808). Multivariate analysis revealed fewer than 300 thyroid resections and fewer than 15 thyroid resections for GD per year, male sex, BMI > 30, autotransplantation of parathyroid glands and previous bilateral thyroid surgery as independent risk factors for postoperative temporary hypoparathyroidism. Reoperations for bleeding (1.3%) were rare. Conclusion: Total thyroidectomy with IONM is safe and currently the most common surgical therapy for GD in Germany. Postoperative hypoparathyroidism is the major complication which should be focused on.
Chemotherapy and Targeted Agents in the Treatment of Elderly Patients with Metastatic Colorectal Cancer
Authors: Tuca Albert , Gallego Rosa , Ghanem Ismael , Gil-Raga Mireia , Feliu Jaime
Published: December 2020

Colorectal cancer (CRC) is one of the main causes of cancer death in the elderly. The older patients constitute a heterogeneous group in terms of functional status, comorbidities, and aging-related conditions. Therefore, therapeutic decisions need to be individualized. Additionally, a higher toxicity risk comes from the fact that pharmacokinetics and pharmacodynamics of the drugs as well as the tissue tolerance can be altered with aging. Although the chemotherapy efficacy in metastatic colorectal cancer (mCRC) is similar for older and young patients, more toxicity is presented in the elderly. While the mono-chemotherapy provides the same benefit for young and older patients, doublets front-line chemotherapy improves progression-free survival (PFS) but not overall survival (OS) in the elderly. Furthermore, the benefit of the addition of bevacizumab to chemotherapy in older patients has been shown in several clinical trials, while the clinical data for the benefit of anti-epidermal growth factor antibodies are scarcer. Immunocheckpoint inhibitors could be an appropriate option for patients with microsatellite instability (MSI) tumors. A prior geriatric assessment is required before deciding the type of treatment in order to offer the best therapeutic option.
Short-Term Effects of Different Types of Anti-Glaucoma Eyedrop on the Sclero-Conjunctival Vasculature Assessed Using Anterior Segment OCTA in Normal Human Eyes: A Pilot Study
Authors: Akagi Tadamichi , Okamoto Yoko , Kameda Takanori , Suda Kenji , Nakanishi Hideo , Miyake Masahiro , Ikeda Hanako Ohashi , Yamada Tatsuya , Kadomoto Shin , Uji Akihito , Tsujikawa Akitaka
Published: December 2020

Background: To investigate the short-term effects of different types of anti-glaucoma eyedrop on sclero-conjunctival vasculatures and their associations with intraocular pressure (IOP) reduction. Methods: This was a prospective study including 20 healthy subjects. A single instillation of ripasudil or bimatoprost was introduced into the right eyes of the participants. The superficial (conjunctival) and deep (intrascleral) vasculatures of the corneal limbus using anterior-segment optical coherence tomography angiography (OCTA) and IOP were examined in both eyes at baseline and 15 min and 2 h after instillation. Results: In the ripasudil group, the vessel density (VD) (median) at baseline (deep, 13.1%; superficial, 28.5%) significantly increased in both layers at 15 min (deep, 19.9%; superficial, 37.3%) and the deep layer at 2 h (deep, 14.8%; superficial, 31.6%). In the bimatoprost group, the superficial VD significantly changed over time, but the deep VD did not. The greater effect of ripasudil on IOP reduction was significantly associated with a lower baseline VD in the deep layer (at 15 min, p = 0.004; at 2 h, p = 0.018). Conclusions: Differences in the timing, depth, and extent of the effects on vasculature after instillations, could be detected using OCTA. The IOP-lowering effects of ripasudil might be associated with the deep vasculature.
Is Interleukin 17 (IL-17) Expression A Common Point in the Pathogenesis of Depression and Obesity?
Authors: Bliźniewska-Kowalska Katarzyna , Szewczyk Bernadeta , Gałecka Małgorzata , Su Kuan-Pin , Maes Michael , Szemraj Janusz , Gałecki Piotr
Published: December 2020

(1) Background: Activated immune-inflammatory pathways play an important role in the pathogenesis of depression and pathological obesity. Obesity might promote production of cytokine interleukin 17, which plays a significant role in neuro-immune reactions. The study aimed at assessing the relationship between Body Mass Index (BMI) and IL-17 expression, taking into account the clinical psychiatric variables in patients with depression. (2) Methods: A total of 125 participants took part in the study (95 depressed patients, 30 healthy controls). Data concerning the course of depressive disorders and BMI were collected. The severity of depressive symptoms was assessed using the Hamilton Depression Rating Scale (HDRS). Reverse transcription polymerase chain reaction (RT-PCR) was used to assess IL-17 gene expression at the mRNA levels, while enzyme-linked immunosorbent assay (ELISA) was used to assess IL-17 expression at the protein level. (3) Results: Patients with more hospitalizations showed significantly higher IL-17 mRNA expression levels and higher BMI. However, no correlation between BMI and IL-17 expression was found in depressed patients. (4) Conclusions: Our study revealed that BMI does not affect IL-17 expression in patients with depression. However, further studies should be conducted to evaluate the effects of IL-17 inhibition on adipose tissue and vice versa.
Challenges and Opportunities from Targeting Inflammatory Responses to SARS-CoV-2 Infection: A Narrative Review
Authors: Lariccia Vincenzo , Magi Simona , Serfilippi Tiziano , Toujani Marwa , Gratteri Santo , Amoroso Salvatore
Published: December 2020

The novel coronavirus disease 2019 (COVID-19) is a global pandemic that continues to sweep across the world, posing an urgent need for effective therapies and prevention of the spread of the severe acute respiratory syndrome related to coronavirus-2 (SARS-CoV-2). A major hypothesis that is currently guiding research and clinical care posits that an excessive and uncontrolled surge of pro-inflammatory cytokines (the so-called “cytokine storm”) drives morbidity and mortality in the most severe cases. In the overall efforts made to develop effective and safe therapies (including vaccines) for COVID-19, clinicians are thus repurposing ready-to-use drugs with direct or indirect anti-inflammatory and immunomodulatory activities. Speculatively, there are many opportunities and challenges in targeting immune/inflammatory processes in the evolving settings of COVID-19 disease because of the need to safely balance the fight against virus and aggressive inflammation versus the suppression of host immune defenses and the risk of additional harms in already compromised patients. To this end, many studies are globally underway to weigh the pros and cons of tailoring drugs used for inflammatory-driven conditions to COVID-19 patient care, and the next step will be to summarize the growing clinical trial experience into clean clinical practice. Based on the current evidence, anti-inflammatory drugs should be considered as complementary approaches to anti-viral drugs that need to be timely introduced in the management of COVID-19 according to disease severity. While drugs that target SARS-CoV-2 entry or replication are expected to confer the greatest benefits at the early stage of the infection, anti-inflammatory drugs would be more effective in limiting the inflammatory processes that drive the worsening of the disease.
Efficacy and Safety of Houttuynia Eye Drops Atomization Treatment for Meibomian Gland Dysfunction-Related Dry Eye Disease: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial
Authors: Liu Zhaolin , Jin Ming , Li Ying , Liu Jun , Xiao Xianghua , Bi Hongsheng , Pan Zhiqiang , Shi Huijun , Xie Xiaofeng , Zhang Minglian , Gao Xuemin , Li Lei , Ouyang Weijie , Tang Liying , Wu Jieli , Yang Yiran , Hu Jiaoyue , Liu Zuguo
Published: December 2020

Purpose: To evaluate the efficacy and safety of Houttuynia eye drops (a Chinese traditional medicine) atomization treatment in meibomian gland dysfunction (MGD)-related dry eye disease (DED) patients. Methods: A total of 240 eligible patients diagnosed with MGD-related DED were assigned either Houttuynia eye drops or placebo for atomization once daily for four weeks in a multi-center, randomized, double-blind, placebo-controlled clinical study. Primary outcome evaluations used included eye symptom score (using the Chinese Dry Eye Questionnaire), meibum quality, and tear break-up time (TBUT), while safety evaluations included adverse events (AEs), visual acuity, and intraocular pressure monitoring. Indicators were measured at baseline as well as one week, two weeks, and four weeks after treatment. Results: Primary outcome measures of the Houttuynia group were improved compared with their placebo counterparts following four-week treatment. Eye symptom scores were significantly reduced relative to the baseline in the Houttuynia group (mean ± standard error of the mean, 9.00 ± 0.61) compared with the placebo group (6.29 ± 0.55; p = 0.0018). Reduction in meibum quality score in the Houttuynia group (0.91 ± 0.10) was also significantly higher compared with the placebo group (0.57 ± 0.10; p = 0.0091), while TBUT in the treatment group (6.30 ± 0.22) was also longer than in the latter (5.60 ± 0.24; p = 0.0192). No medication-related adverse events were observed. Conclusions: Atomization treatment with Houttuynia eye drops is both clinically and statistically effective for the treatment of mild to moderate MGD-related DED patients. This approach is generally safe and was tolerated well by patients.
Canaloplasty in Pigmentary Glaucoma: Long-Term Outcomes and Proposal of a New Hypothesis on Its Intraocular Pressure Lowering Mechanism
Authors: Brusini Paolo , Papa Veronica
Published: December 2020

This study presents the long-term results on canaloplasty in a group of patients affected by pigmentary glaucoma, and studies the progression of the disease after surgery. Material and methods: Twenty-nine eyes of 25 patients with pigmentary glaucoma in maximum tolerated medical therapy with significant visual field damage progression underwent canaloplasty and were followed up to 11 years (mean 59.8 ± 30.1 months). All patients underwent a complete ophthalmic examination every 6 months. Results: The pre-operative mean intraocular pressure (IOP) was 31.8 mmHg ± 10.9 (range 21–70) with an average of 3.3 medications. After 1, 2, 3, and 4 years, the mean IOP was 15.9 ± 4.0, 14.4 ± 7.3, 14.1 ± 2.1, and 15.7 mmHg, respectively, with 0.4, 0.5, and 0.7 medications, respectively. Four patients underwent trabeculectomy after 3 to 30 months due to uncontrolled IOP. Gonioscopy showed a significant reduction of pigment in trabecular meshwork in all cases, starting from the sixth month. In some cases, the pigment was almost completely reabsorbed after two years, suggesting an accelerated transit and escape of the granules through the trabecular spaces. Conclusions: Canaloplasty seems to be a reasonable option in treating patients affected by progressive pigmentary glaucoma. The reabsorption of pigment granules from the trabecular meshwork could, at least in part, explain the relatively high success rate observed after this surgical procedure.
Minimal-Invasive Versus Open Hepatectomy for Colorectal Liver Metastases: Bicentric Analysis of Postoperative Outcomes and Long-Term Survival Using Propensity Score Matching Analysis
Authors: Knitter Sebastian , Andreou Andreas , Kradolfer Daniel , Beierle Anika Sophie , Pesthy Sina , Eichelberg Anne-Christine , Kästner Anika , Feldbrügge Linda , Krenzien Felix , Schulz Mareike , Banz Vanessa , Lachenmayer Anja , Biebl Matthias , Schöning Wenzel , Candinas Daniel , Pratschke Johann , Beldi Guido , Schmelzle Moritz
Published: December 2020

Minimal-invasive hepatectomy (MIH) has been increasingly performed for benign and malignant liver lesions with most promising short-term results. However, the oncological role of MIH in the treatment of patients with colorectal liver metastases (CRLM) needs further investigation. Clinicopathological data of patients who underwent liver resection for CRLM between 2012 and 2017 at the Department of Surgery, Charité-Universitätsmedizin Berlin, and the Inselspital Bern were assessed. Postoperative outcomes und long-term survivals of patients following MIH were compared with those after conventional open hepatectomy (OH) after 1:1 propensity score matching. During the study period, 229 and 91 patients underwent liver resection for CRLM at the Charité Berlin and the Inselspital Bern, respectively. Patients who underwent MIH in one of the two centers (n = 69) were compared with a matched cohort of patients who underwent OH. MIH was associated with lower complication rates (23% vs. 44%, p = 0.011), shorter length of intensive care unit stay (ICU, 1 vs. 2 days, p = 0.043), shorter length of hospital stay (7 vs. 11 days, p < 0.0001), and a reduced need for intraoperative transfusions (12% vs. 25%, p = 0.047) compared to OH. R0 status was achieved in 93% and 75% of patients after MIH and OH, respectively (p = 0.005). After a median follow-up of 31 months, MIH resulted in similar five-year overall survival (OS) rate (56% vs. 48%, p = 0.116) in comparison to OH. MIH for CRLM is associated with lower postoperative morbidity, shorter length of ICU and hospital stay, reduced need for transfusions, and comparable oncologic outcomes compared to the established OH. Our findings suggest that MIH should be considered as the preferred method for the treatment of curatively resectable CRLM.
Osteopontin Predicts Three-Month Outcome in Stroke Patients Treated by Reperfusion Therapies
Authors: Meseguer Elena , Diallo Devy , Labreuche Julien , Charles Hugo , Delbosc Sandrine , Mangin Gabrielle , Monteiro Tavares Linsay , Caligiuri Giuseppina , Nicoletti Antonino , Amarenco Pierre
Published: December 2020

Establishing a prognosis at hospital admission after stroke is a major challenge. Inflammatory processes, hemostasis, vascular injury, and tissue remodeling are all involved in the early response to stroke. This study analyzes whether 22 selected biomarkers, sampled at admission, predict clinical outcomes in 153 stroke patients treated by thrombolysis and mechanical endovascular treatment (MET). Biomarkers were related to hemostasis (u-plasminogen activator/urokinase (uPA/urokinase), serpin E1/PAI-1, serpin C1/antithrombin-III, kallikrein 6/neurosin, alpha 2-macroglobulin), inflammation[myloperoxidase (MPO), chemokine ligand 2/monocyte chemoattractant protein-1 chemokine (CCL2/MCP-1), adiponectin, resistin, cell-free DNA (cDNA), CD40 Ligand (CD40L)], endothelium activation (Vascular cell adhesion protein 1 (VCAM-1) intercellular adhesion molecule 1 (ICAM-1), platelet endothelial cell adhesion molecule 1 (CD31/PECAM-1)], and tissue remodeling (total cathepsin S, osteopontin, cystatin C, neuropilin-1, matrix metallopeptidase 2 (MMP-2), matrix metallopeptidase 3 (MMP-3), matrix metallopeptidase 9 (MMP-9), matrix metallopeptidase 13 (MMP-13)]. Correlations between their levels and excellent neurological improvement (ENI) at 24 h and good outcomes (mRS 0–2) at three months were tested. Osteopontin and favorable outcomes reached the significance level (p = 0.008); the adjusted OR per SD increase in log-transformed osteopontin was 0.34 (95%CI, 0.18–0.62). The relationship between total cathepsin S and MPO with ENI, was borderline of significance (p = 0.064); the adjusted OR per SD increase in log-transformed of total cathepsin S and MPO was 0.54 (95%CI, 0.35–0.81) and 0.51 (95%CI, 0.32–0.80), respectively. In conclusion, osteopontin levels predicted three-month favorable outcomes, supporting the use of this biomarker as a complement of clinical and radiological parameters for predicting stroke prognosis.
Rituximab Use in Warm and Cold Autoimmune Hemolytic Anemia
Authors: Murakhovskaya Irina
Published: December 2020

Autoimmune hemolytic anemia is a rare condition characterized by destruction of red blood cells with and without involvement of complement. It is associated with significant morbidity and mortality. In warm autoimmune hemolytic anemia, less than 50% of patients remain in long-term remission following initial steroid therapy and subsequent therapies are required. Cold agglutinin disease is a clonal hematologic disorder that requires therapy in the majority of patients and responds poorly to steroids and alkylators. Rituximab has a favorable toxicity profile and has demonstrated efficacy in autoimmune hemolytic anemia in first-line as well as relapsed settings. Rituximab is the preferred therapy for steroid refractory warm autoimmune hemolytic anemia (wAIHA) and as part of the first- and second-line treatment of cold agglutinin disease. This article reviews the mechanism of action of rituximab and the current literature on its role in the management of primary and secondary warm autoimmune hemolytic anemia and cold agglutinin disease.
Refinement Orders for Quantitative Information Flow and Differential Privacy
Authors: Chatzikokolakis Konstantinos , Fernandes Natasha , Palamidessi Catuscia
Published: December 2020

Quantitative Information Flow (QIF) and Differential Privacy (DP) are both concerned with the protection of sensitive information, but they are rather different approaches. In particular, QIF considers the expected probability of a successful attack, while DP (in both its standard and local versions) is a max-case measure, in the sense that it is compromised by the existence of a possible attack, regardless of its probability. Comparing systems is a fundamental task in these areas: one wishes to guarantee that replacing a system A by a system B is a safe operation that is the privacy of B is no worse than that of A. In QIF, a refinement order provides strong such guarantees, while, in DP, mechanisms are typically compared w.r.t. the privacy parameter ε in their definition. In this paper, we explore a variety of refinement orders, inspired by the one of QIF, providing precise guarantees for max-case leakage. We study simple structural ways of characterising them, the relation between them, efficient methods for verifying them and their lattice properties. Moreover, we apply these orders in the task of comparing DP mechanisms, raising the question of whether the order based on ε provides strong privacy guarantees. We show that, while it is often the case for mechanisms of the same “family” (geometric, randomised response, etc.), it rarely holds across different families.
Damage Detection in Glass/Epoxy Laminated Composite Plates Using Modal Curvature for Structural Health Monitoring Applications
Authors: Govindasamy Mahendran , Kamalakannan Gopalakrishnan , Kesavan Chandrasekaran , Meenashisundaram Ganesh Kumar
Published: December 2020

This paper deals with detection of macro-level crack type damage in rectangular E-Glass fiber/Epoxy resin (LY556) laminated composite plates using modal analysis. Composite plate-like structures are widely found in aerospace and automotive structural applications which are susceptible to damages. The formation of cracks in a structure that undergoes vibration may lead to catastrophic events such as structural failure, thus detection of such occurrences is considered necessary. In this research, a novel technique called as node-releasing technique in Finite Element Analysis (FEA), which was not attempted by the earlier researchers, is used to model the perpendicular cracks (the type of damage mostly considered in all the pioneering research works) and also slant cracks (a new type of damage considered in the present work) of various depths and lengths for Unidirectional Laminate (UDL) ([0]S and [45]S) composite layered configurations using commercial FE code Ansys, thus simulating the actual damage scenario. Another novelty of the present work is that the crack is modeled with partial depth along the thickness of the plate, instead of the through the thickness crack which has been of major focus in the literature so far, in order to include the possibility of existence of the crack up to certain layers in the laminated composite structures. The experimental modal analysis is carried out to validate the numerical model. Using central difference approximation method, the modal curvature is determined from the displacement mode shapes which are obtained via finite element analysis. The damage indicators investigated in this paper are Normalized Curvature Damage Factor (NCDF) and modal strain energy-based methods such as Strain Energy Difference (SED) and Damage Index (DI). It is concluded that, all the three damage detection algorithms detect the transverse crack clearly. In addition, the damage indicator NCDF seems to be more effective than the other two, particularly when the detection is for damage inclined to the longitudinal axis of the plate. The proposed method will provide the base data for implementing online structural health monitoring of structures using technologies such as Machine Learning, Artificial Intelligence, etc.
Gbx2 Is Required for the Migration and Survival of a Subpopulation of Trigeminal Cranial Neural Crest Cells
Authors: Roeseler David A. , Strader Lona , Anderson Matthew J. , Waters Samuel T.
Published: December 2020

The development of key structures within the mature vertebrate hindbrain requires the migration of neural crest (NC) cells and motor neurons to their appropriate target sites. Functional analyses in multiple species have revealed a requirement for the transcription factor gastrulation-brain-homeobox 2 (Gbx2) in NC cell migration and positioning of motor neurons in the developing hindbrain. In addition, loss of Gbx2 function studies in mutant mouse embryos, Gbx2neo, demonstrate a requirement for Gbx2 for the development of NC-derived sensory neurons and axons constituting the mandibular branch of the trigeminal nerve (CNV). Our recent GBX2 target gene identification study identified multiple genes required for the migration and survival of NC cells (e.g., Robo1, Slit3, Nrp1). In this report, we performed loss-of-function analyses using Gbx2neo mutant embryos, to improve our understanding of the molecular and genetic mechanisms regulated by Gbx2 during anterior hindbrain and CNV development. Analysis of Tbx20 expression in the hindbrain of Gbx2neo homozygotes revealed a severely truncated rhombomere (r)2. Our data also provide evidence demonstrating a requirement for Gbx2 in the temporal regulation of Krox20 expression in r3. Lastly, we show that Gbx2 is required for the expression of Nrp1 in a subpopulation of trigeminal NC cells, and correct migration and survival of cranial NC cells that populate the trigeminal ganglion. Taken together, these findings provide additional insight into molecular and genetic mechanisms regulated by Gbx2 that underlie NC migration, trigeminal ganglion assembly, and, more broadly, anterior hindbrain development.
How Does Aggregate Tax Policy Uncertainty Affect Default Risk?
Authors: Tosun Mehmet Serkan , Yildiz Serhat
Published: December 2020

We examine the impact of aggregate tax policy uncertainty on firm-level default risk. Due to uncertainties associated with tax policies, firms could have difficulties in determining their optimal debt level and use too much debt to increase their values. This can increase firms’ financial risk and default probabilities. At the same time, tax policy uncertainty may lead some firms to take less risk which could lower their use of debt and in turn lower the probability of default. We find that tax policy uncertainty is positively associated with firms’ expected default probabilities. In terms of economic significance, our findings show an increase of 14.83% in expected default probability, on a relative basis. Our results are robust to controlling for conditions of the economy, conditions of the stock market, financial constraints of firms, and credit quality of firms. Our evidence adds to two strands of research: research on taxation and firms’ risk profiles and the impact of policy uncertainty on firms’ decisions.
Exploring Linkages between Supporting, Regulating, and Provisioning Ecosystem Services in Rangelands in a Tropical Agro-Forest Frontier
Authors: Aguilar-Fernández Rocío , Gavito Mayra E. , Peña-Claros Marielos , Pulleman Mirjam , Kuyper Thomas W.
Published: December 2020

Rangeland management in former tropical rainforest areas may affect ecosystem services. We hypothesized that management practices like burning and overgrazing reduce supporting (soil quality) and consequently also provisioning (forage productivity and quality) and regulating (nutrient cycling) ecosystem services. We established 31 exclosures in two landscape categories (alluvial soils, low-hills), documented management practices, and assessed 18 soil quality indicators, litter decomposition as a proxy for nutrient cycling, and forage quantity and quality during one year in grasslands of the Lacandon region, southeast Mexico. Path analysis was used to explore direct and indirect effects of livestock management practices on soil-based ecosystem services. Landscape position had direct effects on management practices, and direct and indirect effects on soil properties. Altitude (a proxy for the soil catena, ranging from alluvial soils along the Lacantún river to Cambisols and Acrisols in the low-hills) was the variable showing most significant negative relations with soil quality and forage production. Decomposition rate was site-specific and had no relation with landscape position and management. Our study suggests that position on the landscape, which relates to nutrient and water availability, had stronger effects than management practices on forage productivity and quality and drives farmers management practices.
Spatio-Temporal Evolution of Land Use Transition and Its Eco-Environmental Effects: A Case Study of the Yellow River Basin, China
Authors: Yin Dengyu , Li Xiaoshun , Li Guie , Zhang Jian , Yu Haochen
Published: December 2020

Human activities and environmental deterioration have resulted in land use transition (LUT), which seriously affects the ecosystem service value (ESV) of its region. Therefore, relevant policy measures are urgently needed. Nevertheless, research on the relationships between LUTs and ESVs from the overall watershed scale is lacking. Thus, the geo-information Tupu method was applied to analyze the dynamic patterns of LUT based on land use data from 1990, 2000, 2010, and 2018 of the Yellow River Basin (YRB). Then, a newly revised ecosystem services calculation method was utilized to the responses of ESV to LUTs. The results indicated that the Tupu units of the LUT were mainly based on the mutual transformation of grassland and unused land, and cultivated land and forestland, which were widely distributed in the upper and middle reaches of the basin. The spatial distribution was concentrated, and the expansion’s trend was also obvious. Moreover, the conversion of cultivated land into construction land was mainly distributed in the lower reaches of the basin. During 1990–2018, the total ESV fluctuated and increased (+10.47 × 108 USD) in the YRB. Thereinto, the ESV of grassland (45%) and forestland (30%) made the greatest contribution to the total ESV. As for different reaches, the ESV increased in the upstream, but decreased in the midstream and the downstream. In terms of contribution rate, the conversion of unused land into grassland (12.477%) and grassland into forestland (9.856%) were the main types to enhance the ESV in the YRB, while the conversion of forestland into grassland (−8.047%) and grassland to unused land (−7.358%) were the main types to reduce the ESV. Furthermore, the range of ecological appreciation zones was widely distributed and scattered, while the range of ecological impairment zones was gradually expanded. These findings could have theoretical support and policy implications for land use planning and environmental services in the YRB.
The Microbiota/Host Immune System Interaction in the Nose to Protect from COVID-19
Authors: Di Stadio Arianna , Costantini Claudio , Renga Giorgia , Pariano Marilena , Ricci Giampietro , Romani Luigina
Published: December 2020

Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and is characterized by variable clinical presentation that ranges from asymptomatic to fatal multi-organ damage. The site of entry and the response of the host to the infection affect the outcomes. The role of the upper airways and the nasal barrier in the prevention of infection is increasingly being recognized. Besides the epithelial lining and the local immune system, the upper airways harbor a community of microorganisms, or microbiota, that takes an active part in mucosal homeostasis and in resistance to infection. However, the role of the upper airway microbiota in COVID-19 is not yet completely understood and likely goes beyond protection from viral entry to include the regulation of the immune response to the infection. Herein, we discuss the hypothesis that restoring endogenous barriers and anti-inflammatory pathways that are defective in COVID-19 patients might represent a valid strategy to reduce infectivity and ameliorate clinical symptomatology.
Structural Behavior of Fibrous-Ferrocement Panel Subjected to Flexural and Impact Loads
Authors: Murali Gunasekaran , Amran Mugahed , Fediuk Roman , Vatin Nikolai , Raman Sudharshan N. , Maithreyi Gundu , Sumathi Arunachalam
Published: December 2020

Ferrocement panels, while offering various benefits, do not cover instances of low and moderated velocity impact. To address this problem and to enhance the impact strength against low-velocity impact, a fibrous ferrocement panel is proposed and investigated. This study aims to assess the flexural and low-velocity impact response of simply supported ferrocement panels reinforced with expanded wire mesh (EWM) and steel fibers. The experimental program covered 12 different ferrocement panel prototypes and was tested against a three-point flexural load and falling mass impact test. The ferrocement panel system comprises mortar reinforced with 1% and 2% dosage of steel fibers and an EWM arranged in 1, 2, and 3 layers. For mortar preparation, a water-cement (w/c) ratio of 0.4 was maintained and all panels were cured in water for 28 days. The primary endpoints of the investigation are first crack and ultimate load capacity, deflection corresponding to first crack and ultimate load, ductility index, flexural strength, crack width at ultimate load, a number of impacts needed to induce crack commencement and failure, ductility ratio, and failure mode. The finding revealed that the three-layers of EWM inclusion and steel fibers resulted in an additional impact resistance improvement at cracking and failure stages of ferrocement panels. With superior ultimate load capacity, flexural strength, crack resistance, impact resistance, and ductile response, as witnessed in the experiment program, ferrocement panel can be a positive choice for many construction applications subjected to repeated low-velocity impacts.
Cuspal Deflection and Temperature Rise of MOD Cavities Restored through the Bulk-Fill and Incremental Layering Techniques Using Flowable and Packable Bulk-Fill Composites
Authors: Santis Roberto De , Lodato Vincenzo , Gallicchio Vito , Prisco Davide , Riccitiello Francesco , Rengo Sandro , Rengo Carlo
Published: December 2020

Background: The aim of this study was to investigate cuspal deflection caused by material shrinkage and temperature rise occurring in the pulp chamber during photopolymerization. The aim of this study was also to investigate the effect of flowable and packable bulk-fill composites on cuspal deflection occurring in mesio-occlusal–distal (MOD) cavities restored through the bulk-fill or through the incremental layering technique. Additionally, mechanical and thermal properties of bulk-fill composites were considered. Methods: Two bulk-fill composites (high-viscosity and low-viscosity), largely differing in material composition, were used. These composites were characterized through linear shrinkage and compressive test. Cuspal deformation during restoration of mesio-occlusal–distal cavities of human premolars was evaluated using both the bulk-fill and the incremental layering techniques. Temperature rise was measured through thermocouples placed 1 mm below the cavity floor. Results: Shrinkage of the flowable composite was significantly higher (p < 0.05) than that of packable composite, while mechanical properties were significantly lower (p < 0.05). For cusp distance variation, no significant difference was observed in cavities restored through both restorative techniques, while temperature rise values spanned from 8.2 °C to 11.9 °C. Conclusions: No significant difference in cusp deflection between the two composites was observed according to both the restorative techniques. This result can be ascribed to the Young’s modulus suggesting that the packable composite is stiffer, while the flowable composite is more compliant, thus balancing the cusp distance variation. The light curing modality of 1000 mW/cm2 for 20 s can be considered thermally safe for the pulp chamber.
Analytical Evaluation of the Dendritic Structure Parameters and Crystallization Rate of Laser-Deposited Cu-Fe Functionally Graded Materials
Authors: Makarenko Konstantin , Dubinin Oleg , Shishkovsky Igor
Published: December 2020

The paper is devoted to the direct energy deposition (DED) of functionally graded materials (FGMs) created from stainless steel and aluminum bronze with 10% content of Al and 1% of Fe. The results of the microstructure analysis using scanning electronic microscopy (SEM) demonstrate the existence of a dendritic structure in the specimens. The crystallization rate of the gradient binary Cu-Fe system structures was investigated and calculated using the model of a fast-moving concentrated source with an ellipsoid crystallization front. The width of the secondary elements of the dendrites in the crystallized slab was numerically estimated as 0.2 nm at the center point of the circle heat spot, and the two types of dendrites were predicted in the specimen: the dendrites from 0.2 to approximately 50 nm and from approximately 0.1 to 0.3 μm in width of the secondary elements. The results were found to be in good accordance with the measured experimental values of the dendritic structure geometry parameters.
Direct Generation of High-Aspect-Ratio Structures of AISI 316L by Laser-Assisted Powder Deposition
Authors: Alvarez Piera , Montealegre M. Ángeles , Cordovilla Francisco , García-Beltrán Ángel , Angulo Ignacio , Ocaña José Luis
Published: December 2020

The effect of process parameters and the orientation of the cladding layer on the mechanical properties of 316L stainless steel components manufactured by laser metal deposition (LMD) was investigated. High aspect-ratio walls were manufactured with layers of a 4.5 mm wide single-cladding track to study the microstructure and mechanical properties along the length and the height of the wall. Samples for the tensile test (according to ASTM E-8M-04) were machined from the wall along both the direction of the layers and the direction perpendicular to them. Cross-sections of the LMD samples were analyzed by optical and scanning electron microscopy (SEM). The orientation of the growing grain was observed. It was associated with the thermal gradient through the building part. A homogeneous microstructure between consecutive layers and some degree of microporosity was observed by SEM. Uniaxial tension tests were performed on samples extracted from the wall in perpendicular and parallel directions. Results for ultimate tensile strength were similar in both cases and with the wrought material. The σ0.2 were similar in both cases but slightly superior to the wrought material.
Influence of Wetting and Drying Cycles on Physical and Mechanical Behavior of Recycled Aggregate Concrete
Authors: Rangel Caroline S. , Amario Mayara , Pepe Marco , Martinelli Enzo , Toledo Filho Romildo D.
Published: December 2020

Recently, concerns have been rising about the impact of increasing the depletion of natural resources and the relevant generation of construction and demolition waste, on the environment and economy. Therefore, several efforts have been made to promote sustainable efficiency in the construction industry and the use of recycled aggregates derived from concrete debris for new concrete mixtures (leading to so-called recycled aggregate concrete, RAC) is one of the most promising solutions. Unfortunately, there are still gaps in knowledge regarding the durability performances of RAC. In this study, we investigate durability of structural RAC subjected to wet-dry cycles. We analyze the results of an experimental campaign aimed at evaluating the degradation process induced by wetting and drying cycles on the key physical and mechanical properties of normal- and high-strength concrete, produced with coarse recycled concrete aggregates (RCAs) of different sizes and origins. On the basis of the results we propose a degradation law for wetting and drying cycles, which explicitly makes a possible correlation between the initial concrete porosity, directly related to the specific properties of the RCAs and the resulting level of damage obtained in RAC samples.
Diffusion Mechanism of Cinnamon Essential Oils Release from Calcium Alginate Based Controlled Release Films in Contact with Food Simulating Solvent
Authors: Chen Xi , Lu Li-Xin , Yao Wei-Rong , Pan Liao
Published: December 2020

Calcium alginate based controlled release films with moderate mechanical properties were fabricated in this paper. The diffusion mechanism of these films contacting food simulating solvent (FSS) was explored in some detail. With the increase of glycerol content, the diffusion coefficient (D) values of cinnamon essential oils (CEOs) diffusing to ethanol first increased slowly (0.3–0.6 mL), then vigorously (0.6–0.9 mL), and then mildly (0.9–1.2 mL). The D values of the CEOs diffused to water are all in the order of magnitude of 10−10 cm2/s. The D values of CEOs diffused from films EG3 and EGC1 to aqueous ethanol altered enormously at a small moisture percentage (w = 0.3), then continuously varied vigorously, and at last altered mildly in the range of w = 0.3–1. All the results above indicate that, considering the FSS, the diffusion ability of molecules is jointly determined by the size and distribution of free volume in the system (polymer + diffusive substance + solvents), the intermolecular interaction, and the partition coefficient of the solvents. In addition, several pairs of D values, such as DEG and DGA, are very close to each other, indicating that different kinds of interactions between different groups may have the same effect on the diffusion ability of molecules. The correlation between D1 and D2 indicates that polymeric emulsifier chains also exist in the polymer-rich layer. All the findings and analysis could provide the theoretical basis and data support for further molecular dynamic simulation and could guide the design of controlled release food packaging for food protection.
Fatigue Resistance of Bituminous Mixtures and Mortars Containing High Reclaimed Asphalt Content
Authors: Margaritis Alexandros , Jacobs Geert , Pipintakos Georgios , Blom Johan , Van den bergh Wim
Published: December 2020

With the increased use of reclaimed asphalt (RA), the ability of bituminous materials to resist fatigue cracking may face a decline mainly due to the aged reclaimed asphalt binder (RAB), especially when RA is used at higher rates and not sufficiently treated. In this study, the bulk scale (asphalt) and its subscale (mortar) were employed to evaluate the effect on fatigue resistance when a RAB is added, by considering three replacement rates: 0%, 40%, and 70% RAB. The fatigue testing of asphalt mixtures was carried out using a four-point bending (4PB) setup, while the mortars were tested using a new column-like geometry utilising a dynamic shear rheometer (DSR). The fatigue properties were further analysed using dissipated energy concepts. The aim of this study was, first, to assess whether the inclusion of a RAB can provide at least similar fatigue properties compared to an all-virgin mix, and second, to evaluate whether the proposed treatment is beneficial for the mixtures with a RAB. The asphalt tests revealed that the inclusion of a 40% RAB led to increased fatigue resistance, whereas the mortar tests showed that the inclusion of RAB has an inverse effect on fatigue life.
Study of Radiation-Induced Defects in p-Type Si1−xGex Diodes before and after Annealing
Authors: Ceponis Tomas , Lastovskii Stanislau , Makarenko Leonid , Pavlov Jevgenij , Pukas Kornelijus , Gaubas Eugenijus
Published: December 2020

In this work, electrically active defects of pristine and 5.5 MeV electron irradiated p-type silicon–germanium (Si1−xGex)-based diodes were examined by combining regular capacitance deep-level transient spectroscopy (C-DLTS) and Laplace DLTS (L-DLTS) techniques. The p-type SiGe alloys with slightly different Ge contents were examined. It was deduced from C-DLTS and L-DLTS spectra that the carbon/oxygen-associated complexes prevailed in the pristine Si0.949Ge0.051 alloys. Irradiation with 5.5 MeV electrons led to a considerable change in the DLT spectrum containing up to seven spectral peaks due to the introduction of radiation defects. These defects were identified using activation energy values reported in the literature. The double interstitial and oxygen complexes and the vacancy, di-vacancy and tri-vacancy ascribed traps were revealed in the irradiated samples. The interstitial carbon and the metastable as well as stable forms of carbon–oxygen (CiOi* and CiOi) complexes were also identified for the electron-irradiated SiGe alloys. It was found that the unstable form of the carbon–oxygen complex became a stable complex in the irradiated and the subsequently annealed (at 125 °C) SiGe samples. The activation energy shifts in the radiation-induced deep traps to lower values were defined when increasing Ge content in the SiGe alloy.
The Curing Rheokinetics of Epoxyphosphazene Binders
Authors: Bornosuz Natalia V. , Gorbunova Irina Yu. , Kireev Vyacheslav V. , Onuchin Denis V. , Kerber Mikhail L. , Petrakova Viktoria V. , Kryuchkov Ivan A. , Nevskiy Roman E. , Sokovishin Alexey V. , Khammatova Venera V. , Sirotin Igor S.
Published: December 2020

The influence of epoxyphosphazene-modifying additives on the features of the hot curing process of epoxy-amine composition was studied by the rotational viscometry method. The modification caused an acceleration of the curing process, changed rheokinetics of viscosity increase, especially the stage molecular mass growth of linear chains became almost twice shorter for composition with 30% modifier than for unmodified one. We suggest the reason for these changes is the polyfunctionality of epoxyphosphazene, which finally results in high-density network formation. In cold curing process the bulkiness of epoxyphosphazene molecule and the lack of heat for its motion results in incomplete cure. Thus, in order to cope with these difficulties hot curing systems were proposed and studied.