bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of ERα-36 expression with the de novo resistance of tamoxifen in ER-positive breast cancer
Authors: Juliansyah Amir , Rahman Septiman , Indra Indra , Nelwan Berti , Prihantono Prihantono
Published: May 2021

BACKGROUND: Approximately 70–80% of breast cancer express ER-alpha and hormonal therapies, given significant improvements in patient survival. About 50% of ER-positive breast cancer patients with advanced disease insensitive to tamoxifen treatment when diagnosed. Recent studies have shown that ERα-36 is a crucial factor in the resistance of tamoxifen. OBJECTIVE: This study aims to determine the association between ERα-36 expression and de novo resistance of tamoxifen in patients with ER-positive breast cancer. METHODS: This study was an observational study using a cross-sectional method and was conducted at Wahidin Sudirohusodo Hospital and Unhas Hospital. ERα-36 protein expression was assessed using an immunohistochemistry assay. The association of ERα-36 expression and resistance of tamoxifen was tested with the Chi-square test. RESULTS: A total of 50 locally advanced breast cancer cases were included in this study, 22 cases (44%) had overexpression of ERα-36, and 28 cases (56%) had not, 24 cases (48%) had experience resistance to tamoxifen and 26 cases (52%) had not. There was a significant association between ERα-36 expressions and resistance of tamoxifen (p = 0.000). CONCLUSIONS: There was an association between the expression of ER-α36 with de novo resistance of tamoxifen in ER-positive breast cancer. ER-α36 could act as a worth considering biomarker for de novo resistance of tamoxifen in therapeutic strategies.
The Association of Essential Metals with APOE Genotype in Alzheimer’s Disease
Authors: Babić Leko Mirjana , Jurasović Jasna , Nikolac Perković Matea , Španić Ena , Sekovanić Ankica , Orct Tatjana , Lukinović Škudar Vesna , Bačić Baronica Koraljka , Kiđemet-Piskač Spomenka , Vogrinc Željka , Pivac Nela , Borovečki Fran , Hof Patrick R. , Šimić Goran
Published: May 2021

Background: The major confirmed genetic risk factor for late-onset, sporadic Alzheimer’s disease (AD) is variant ɛ4 of apolipoprotein E gene (APOE). It is proposed that ApoE, a protein involved in transport of cholesterol to neurons can cause neurodegeneration in AD through interaction with metals. Previous studies mostly associated copper, iron, zinc, and calcium with ApoE4-mediated toxicity. Objective: To test the association of essential metals with APOE genotype. Methods: We compared plasma and cerebrospinal fluid (CSF) levels of copper, zinc, iron, sodium, magnesium, calcium, cobalt, molybdenum, manganese, boron, and chromium, and CSF ferritin levels among AD, mild cognitive impairment (MCI) patients, and healthy controls (HC) with different APOE genotype. Results: Sodium, copper, and magnesium levels were increased in carriers of ɛ4 allele. Additionally, the increase in sodium, calcium and cobalt plasma levels was observed in carriers of ɛ4/ɛx genotype. The decrease in boron plasma levels was observed in carriers of ɛ4 allele and ɛ4/ɛ4 genotype. Additionally, CSF zinc levels as well as plasma sodium levels were increased in AD patients compared to HC. Conclusion: These results indicate that the molecular underpinnings of association of essential metals and metalloids with APOE should be further tested and clarified in vivo and in vitro.
Lung Function Impairment and the Risk of Incident Dementia: The Rotterdam Study
Authors: Xiao Tian , Wijnant Sara R.A. , Licher Silvan , Terzikhan Natalie , Lahousse Lies , Ikram M. Kamran , Brusselle Guy G. , Ikram M. Arfan
Published: May 2021

Background: The etiology of dementia may partly be underpinned by impaired lung function via systemic inflammation and hypoxia. Objective: To prospectively examine the association between chronic obstructive pulmonary disease (COPD) and subclinical impairments in lung function and the risk of dementia. Methods: In the Rotterdam Study, we assessed the risk of incident dementia in participants with Preserved Ratio Impaired Spirometry (PRISm; FEV1/FVC≥0.7, FEV1 < 80% predicted) and in participants with COPD (FEV1/FVC < 0.7) compared to those with normal spirometry (controls; FEV1/FVC≥0.7, FEV1≥80% predicted). Hazard ratios (HRs) with 95% confidence intervals (CI) for dementia were adjusted for age, sex, education attainment, smoking status, systolic blood pressure, body mass index, triglycerides, comorbidities and Apolipoprotein E (APOE) genotype. Results: Of 4,765 participants, 110 (2.3%) developed dementia after 3.3 years. Compared to controls, participants with PRISm, but not COPD, had an increased risk for all-type dementia (adjusted HRPRISm 2.70; 95% CI, 1.53–4.75; adjusted HRCOPD 1.03; 95% CI, 0.61–1.74). These findings were primarily driven by men and smokers. Similarly, participants with FVC% predicted values in the lowest quartile compared to those in the highest quartile were at increased risk of all-type dementia (adjusted HR 2.28; 95% CI, 1.31–3.98), as well as Alzheimer’s disease (AD; adjusted HR 2.13; 95% CI, 1.13–4.02). Conclusion: Participants with PRISm or a low FVC% predicted lung function were at increased risk of dementia, compared to those with normal spirometry or a higher FVC% predicted, respectively. Further research is needed to elucidate whether this association is causal and how PRISm might contribute to dementia pathogenesis.
Auto-weighted concept factorization for joint feature map and data representation learning
Authors: Zhang Yikai , Peng Yong , Bian Hongyu , Ge Yuan , Qin Feiwei , Kong Wanzeng
Published: May 2021

Concept factorization (CF) is an effective matrix factorization model which has been widely used in many applications. In CF, the linear combination of data points serves as the dictionary based on which CF can be performed in both the original feature space as well as the reproducible kernel Hilbert space (RKHS). The conventional CF treats each dimension of the feature vector equally during the data reconstruction process, which might violate the common sense that different features have different discriminative abilities and therefore contribute differently in pattern recognition. In this paper, we introduce an auto-weighting variable into the conventional CF objective function to adaptively learn the corresponding contributions of different features and propose a new model termed Auto-Weighted Concept Factorization (AWCF). In AWCF, on one hand, the feature importance can be quantitatively measured by the auto-weighting variable in which the features with better discriminative abilities are assigned larger weights; on the other hand, we can obtain more efficient data representation to depict its semantic information. The detailed optimization procedure to AWCF objective function is derived whose complexity and convergence are also analyzed. Experiments are conducted on both synthetic and representative benchmark data sets and the clustering results demonstrate the effectiveness of AWCF in comparison with some related models.
Consecutive z-index vertex magic labeling graphs
Authors: Nishanthini Radhakrishnan , Jeyabalan Ramasamy , Balasundar Samipillai , Kumar Gurunathan
Published: May 2021

The conception of magic labeling in fuzzy graphs elongates to fuzzy vertex magic labeling together with consecutive non-integer values in (0, 1] and the graph’s repercussion is named as fuzzy consecutive vertex magic labeling graphs (FCVM) along with the z-index. In this manuscript, we give some properties associated with FCVM labeling along with z-index as well as the presence of FCVM labeling with z-index in trees and some generalizations. Moreover, we examine the FCVM labeling along with z-index of both regular and irregular graphs. Finally, in real-time applications, we bestow an instance for fuzzy consecutive vertex magic labeling graphs.
Challenges and issues in the development of the human healthcare system
Authors: Huang Zhichao
Published: May 2021

The social health care system is a single-stop solution for overseas patients seeking worldwide. Human is linked to globally certified healthcare companies, clinics, dental centers, and allows patients to access the best medical care. The significant challenges in developing the human healthcare system include efficiency, security, and sustainable medical devices linked to the Internet. A healthcare system usually includes different intelligent technologies from various disciplines. This manuscript proposed a Virtual reality-based Integrated delivery model (VRIDS) for the healthcare system to minimize the challenges. This paper uses Exclusive Provider Organizations’ methods, Point-of-Service methods, for developing the human health system. VRIDS provides a Higher quality of care with more efficiency in tracking the body’s movements to view the human’s inner body and allow an immersion sensation. Finally, results from various patients and doctors are highly recommended in these techniques to improve the human healthcare system and a cost-effective system and convenience to patients and doctors. The experimental results have been performed, and the suggested VRIDS model enhances the accuracy ratio of 97.8%, sensitivity ratio of 98.2%, decision-making level 96.5%, network performance ratio of 97.1%, and quality of service of 98.3% compared to other existing methods.
The application of deep learning in college students’ sports cognition and health concept
Authors: Wang Pin , Chi Xiaopeng , Yu Yue
Published: May 2021

Researchers and scientists in practical sports psychology are involved in the sports psychology practice process. Current models of training appear unsatisfied to assist trainees in psychology to learn the necessary humanistic skills for the requirement of athlete-centered services. This article aims to include an example of the value of Deep Neural Network Assisted Reflective Approaches (DNARA) as an alternative to clinical training, which may enable practitioners to manage themselves better in action. It addresses the essence of professional understanding; To describe reflection and present common examples of a reflective method in the “education professions” during the creation of reflective practice. It discusses how reflective exercise can support a clinician’s professional and personal growth within the field of sport psychology and illustrate how reflective practice may improve. Finally, there is a discussion about appropriate platforms for the distribution of insightful content. DNARA method achieves the highest classification accuracy of 94.12%, and error rate is reduced to 0.40, and DNARA method is more efficient for student health concepts.
The music psychology that uses fuzzy models to promote mental health
Authors: Hao Weiyi
Published: May 2021

Through the analysis of design psychology, this paper first sorts out the development context of design psychology, and then elaborates the definition of design psychology. Moreover, this paper combines the actual demands of music psychology to construct a model, applies the fuzzy model to this model, and systematically studies the basic concepts of design psychology. Simultaneously, this paper combines its concept with examples of interface interaction design of mobile Internet product to study and observe the application of design psychology in this field. In addition, this paper summarizes a set of scientific and reasonable specific methods for interface interaction design, and then uses this method to guide the practice of system model interaction design, constructs the model structure based on demand analysis, and optimizes the system structure. Finally, this paper designs experiments to verify the performance of the model. The research results show that the model constructed in this paper has certain practical effects.
Financial market volatility based on complex network and fuzzy logic theory
Authors: Li Zhiyang
Published: May 2021

Volatility is an inherent attribute of the financial market, which is usually expressed as the degree of volatility of financial asset prices. The volatility of the financial market means that there is uncertainty or risk in the market. This paper mainly studies financial market fluctuations based on complex networks and fuzzy logic theory. This article first systematically organizes and summarizes the theoretical construction of complex networks and fuzzy logic. In terms of complex networks, the definition of complex networks, the theory of commonly used functions (classical models of complex networks) and the solving methods are sorted out. In the construction of fuzzy logic theory, starting with quantifiable financial market volatility indicators, the construction models of realized volatility and implied volatility are discussed, and complex network models of implied volatility and model-free models are discussed. The theoretical construction methods were compared and analyzed. Finally, it summarizes the theoretical construction methods of implied volatility index and points out the advantages of model-free implied volatility as a market volatility and risk measurement index, which contains more effective future risk information and is based on implied volatility. The empirical research on indexes and complex network models has laid a theoretical foundation. Experimental data shows that the bond market and the foreign exchange market have the largest fluctuations in the correlation coefficient, reaching 0.35; followed by the stock market and the bond market, which is about 0.17; the stock market and foreign exchange market with the smallest fluctuations are about 0.08. The experimental results show that the financial market volatility research data based on complex networks and fuzzy logic theory is more accurate.
Validating a Seated Virtual Reality Threat Paradigm for Inducing Anxiety and Freezing of Gait in Parkinson’s Disease
Authors: Quek Dione Y. L. , Economou Kristin , MacDougall Hamish , Lewis Simon J.G. , Ehgoetz Martens Kaylena A.
Published: May 2021

Background: Although prior research has established that freezing of gait (FOG) in Parkinson’s disease (PD) is associated with anxiety, only one study to date has directly manipulated anxiety levels to induce FOG. Objective: The current study aimed to replicate these previous findings and evaluate whether a seated version of a ‘threat’ virtual reality (VR) paradigm could induce anxiety and provoke FOG. Methods: Twenty-four PD patients with FOG were assessed across various threat conditions in both a walking VR paradigm (Experiment 1) and a seated VR paradigm (Experiment 2). Both paradigms manipulated the height (i.e., elevated vs ground) and width (wide vs narrow) of the planks participants were instructed to walk across. Results: Across both experiments, the Elevated + Narrow condition provoked significantly greater number of freezing episodes compared to all other conditions. Higher levels of self-reported anxiety were reported during the Elevated+Narrow condition compared to all other conditions in Experiment 1, and compared to the Ground condition in Experiment 2. Conclusion: These findings confirm that anxiety contributes to FOG and validates the use of a seated VR threat paradigm for provoking anxiety-related freezing. This enables future studies to combine this paradigm with functional MRI to explore the neural correlates underlying the role of anxiety in FOG.
Inclination, hip abduction, orientation, and tone affect weight-bearing in standing devices
Authors: Paleg Ginny , Altizer Wendy , Malone Rachel , Ballard Katie , Kreger Alison
Published: May 2021

PURPOSE: With children who are unable to stand or walk independently in the community, therapists commonly use standing devices to assist lower-extremity weight-bearing which is important for bone and muscle health. In addition, positioning in hip abduction may improve hip stability and range of motion. This is the first study to explore the effect of angle of inclination, hip abduction, body orientation, and tone on weight-bearing in pediatric standing devices. METHODS: This descriptive exploratory study used a convenience sample of 15 participants (2 with normal tone, 5 with generalized hypotonia, and 8 with hypertonia) (mean age of 5 years and 10 months, range of 3 years 4 months to 9 years 7 months); 13 of whom used standing devices at home, as well as 2 typically developing siblings (normal tone). Each child stood in 36 positions to measure the amount of weight-bearing through footplates. RESULTS: Weight-bearing was highest with 60 degrees of abduction and no inclination (upright) in supine positioning for children with low and normal tone. Children with high muscle tone bore most weight through their feet with no abduction (feet together) and no inclination (upright) in prone positioning. Overall, supine positioning resulted in more weight-bearing in all positions for children with low and normal tone. Prone positioning resulted in slightly more weight-bearing in all positions for children with high tone. CONCLUSIONS: Weight-bearing was affected by all three of the variables (inclination, abduction, and orientation) for participants with high, normal, and low tone. To determine optimal positioning, all standers should include a system to measure where and how much weight-bearing is occurring in the device.
Multi-exposure X-ray image fusion quality evaluation based on CSF and gradient amplitude similarity
Authors: Qi Yanjie , Yang Zehui , Kang Lin
Published: May 2021

Due to the limitation of dynamic range of the imaging device, the fixed-voltage X-ray images often produce overexposed or underexposed regions. Some structure information of the composite steel component is lost. This problem can be solved by fusing the multi-exposure X-ray images taken by using different voltages in order to produce images with more detailed structures or information. Due to the lack of research on multi-exposure X-ray image fusion technology, there is no evaluation method specially for multi-exposure X-ray image fusion. For the multi-exposure X-ray fusion images obtained by different fusion algorithms may have problems such as the detail loss and structure disorder. To address these problems, this study proposes a new multi-exposure X-ray image fusion quality evaluation method based on contrast sensitivity function (CSF) and gradient amplitude similarity. First, with the idea of information fusion, multiple reference images are fused into a new reference image. Next, the gradient amplitude similarity between the new reference image and the test image is calculated. Then, the whole evaluation value can be obtained by weighting CSF. In the experiments of MEF Database, the SROCC of the proposed algorithm is about 0.8914, and the PLCC is about 0.9287, which shows that the proposed algorithm is more consistent with subjective perception in MEF Database. Thus, this study demonstrates a new objective evaluation method, which generates the results that are consistent with the subjective feelings of human eyes.
Design of flowing refractometer with cylindrical insert in the form a vertical pipeline section for control to clear media state
Authors: Davydov Vadim V. , Nikolaev Denis I. , Moroz Angelina V.
Published: May 2021

The article a the new design of flowing refractometer of differential type for media condition control both in laminar and turbulent flow regimes is considered. Given the peculiarities of the location of the flow and closed cuvette and the angles of incidence of laser radiation on their walls we have implemented a new method of measuring the refractive index n in new developed design of refractometer. This allowed us to make the influence of a number of errors related with unbalance voltage on the photoelectric converter, with an increase in the number of reflections between optical elements of laser radiation, with the presence of a transport link for the selection of flowing fluid and temperature fluctuations on the result of measuring the refractive index. The technique allowing to reduce the influence of change of the optical density of the flowing liquid on the measurement error of refractive index is proposed. The results of experimental investigations for different media are presented.
Proposta De Revitalização Nos Processos De Comunicação Interna: Estudo De Caso Na Empresa Jr Log Transportes E Logísticas
Authors: Martins Brenda Brasil , Andrade Eduarda Fernanda Gomes de , Oliveira Daniel Barroso de , Roberto José Carlos Alves
Published: May 2021

A abordagem do conteúdo a ser apresentado busca demonstrar que, de forma estratégica, a revitalização nos processos de comunicação interna pode ser alcançada ao ser aplicada. O presente estudo surgiu a partir da verificação das áreas críticas efetuadas na empresa JR LOG transportes, que atua no segmento transportes em Manaus. Baseado nas informações da coleta de dados e análise do conteúdo, constatou-se menor desempenho no setor do RH em decorrência da falta da comunicação interna. O propósito do presente estudo é apresentar a comunicação interna e seu desempenho vital como ferramenta estratégica, focando no desenvolvimento e engajamento de seus clientes internos, e para tanto, apresenta os seguintes objetivos específicos: Possibilitar aos clientes internos o conhecimento das transformações ocorridas no seu local de trabalho; Tornar essencial a presença dos clientes internos no andamento dos negócios; Facilitar a comunicação interna, deixando-a clara e objetiva para o público interno. A criação dos indicadores para ações interventivas fez-se imprescindível, em razão da necessidade de um tratamento adequado da área crítica. Por essa razão foi-se necessário implementar a ferramenta 5W2H, a fim de auxiliar na proposta da implementação dos seguintes atos de evolução: Analisar ruídos na comunicação, coordenar integração de todos os setores, aplicar ferramentas eficientes de comunicação, empregar colaboradores sem voz nem participação, categorizar feedbacks positivos e negativos. Após cumprimento da proposta, espera-se que a organização, dessa forma, melhore suas estratégias de relacionamento com sua equipe, visando o desenvolvimento de colaboradores eficientes, competentes e eficazes. Com pequenas mudanças dentro da organização é possível mudar o clima organizacional e, consequentemente, os resultados.
Importância Da Interdisciplinaridade Na Formação Docente No Processo De Letramento
Authors: Santos Antonia do Nascimento Pereira , Rodrigues Juracy Santana , Farias Ana Rosa Santos
Published: May 2021

O trabalho de pesquisa objetivou propor reflexões para compreender como a proposta interdisciplinar pode contribuir para o aperfeiçoamento da formação docente, ao assumir os enfrentamentos que a escola possui em relação ao ensino e aprendizagem. Nesse contexto, a abordagem interdisciplinar, propõe uma nova possibilidade para que os profissionais da educação reflitam sobre as práticas pedagógicas que envolvem o ato de ler e escrever no processo de letramento. Assim, considerando essa problemática, questionamos: Qual a importância da interdisciplinaridade na formação docente na construção do processo de letramento? Os encaminhamentos metodológicos dessa pesquisa são de abordagem qualitativa, de cunho bibliográfico, que respaldam as discussões de autores que destacam os desafios do saber docente na construção do processo de letramento. Tendo em vista a importância a formação do professor nos processos que envolvem a leitura e a escrita, busca-se a adequação de um currículo flexível e dinâmico, que contemple os diversos campos dos saberes de forma articulada e não estática, como preconiza a tradição cartesiana. Além das contribuições de abordagens sócio-históricas, que se constituem em um relevante suporte para entender, o quanto as interações sociais promovem o desenvolvimento de competências dos diversos saberes que permeiam o processo de letramento.
Proposta De Implementação Da Ferramenta CRM No Relacionamento Com Clientes E Colaboradores: Estudo De Caso Na Empresa Vap Informática LTDA
Authors: Silva Matheus Dantas da , Silva Junior Paulo Egídio Ribeiro da , Maciel Pedro Henrique Pereira , Ramos Jose Manoel , Roberto Jose Carlos Alves
Published: May 2021

O presente estudo realizado na empresa VAP INFORMÁTICA evidenciou-se a partir da análise problemática e possível proposta de solução necessária para mudanças positivas dentro da empresa, identificou-se através de entrevistas e questionários dentro da área do Marketing como sendo a de menor desempenho. Aprofundou-se o estudo delineado como objetivo geral reter, aprofundar e captar novos e fiéis clientes a partir da gestão do marketing de serviços na empresa. Sendo assim, o objetivo do projeto foi criar uma proposta de implementação futura para a empresa VAP INFORMATICA, identificando com a aplicação da ferramenta CRM para melhoria contínua e o mapeamento dos processos da empresa, como objetivos específicos buscou-se identificar quais as dificuldades que podem ser encontradas durante a etapa de implementação da ferramenta CRM; Especificar as principais vantagens proporcionadas na utilização da Ferramenta CRM para o encantamento, captação e retenção de novos clientes; Analisar as estratégias e identificar porque o CRM é importante para os colaboradores da empresa em nível de continuidade dos atendimentos com a clientela.
Protocolo De Exames Clinicos E Complementares Básicos Para Tratamentos Reabilitadores Em Caso De Pacientes Em Colapso Oclusal Severo: Relato De Caso Clínico
Authors: Cavalcante Jeane Batista dos Santos , Ávila Marcelo de Faria Souza
Published: May 2021

A reabilitação oral restabelece a correta relação maxilo-mandibular, dando capacidade mastigatória, estética facial e o bem-estar do paciente. Esta reabilitação está ligada a um bom planejamento do caso, para levar a um diagnóstico correto, sendo assim, é preciso avaliar o paciente como um todo. Este trabalho propõe e ilustra uma sequência de exames clínicos e complementares básicos para diagnóstico, planejamento e execução de reabilitação oral de pacientes em colapso oclusal severo. Com a tomada de fotos e montagem dos modelos de estudo no articulador para entender o inter-relacionamento dentário nos movimentos funcionais do paciente, considerando na análise da oclusão, como relação cêntrica, máxima intercuspidação, dimensão vertical de oclusão, dimensão vertical de repouso, guia anterior dos movimentos mandibulares, guia canina dos movimentos de lateralidade, desgastes oclusais e contatos prematuros. Concluímos que é de suma importância a minuciosa análise oclusal do paciente através de meios simples e eficientes para o restabelecimento de uma oclusão ideal em um paciente em colapso oclusal severo, facilitando o diagnóstico e planejamento da reabilitação oral do paciente.
Las cuentas medioambientales físicas en el INE: situación actual y perspectivas futuras
Authors: Celestino Fernando , Maestro López Julia , Martín Salvador Luis
Published: May 2021

Las Cuentas Medioambientales Físicas muestran, en términos físicos, como el medioambiente contribuye al desarrollo económico (por ejemplo, por medio de la extracción de recursos naturales), los impactos que la economía tiene sobre el medioambiente (por ejemplo, consumo de energía, emisiones a la atmósfera, generación de residuos, contaminación, pérdida de biodiversidad), así como el agotamiento del capital natural (recursos energéticos naturales, agua, bosques y tierra). En este artículo se presentan las cuatro cuentas medioambientales físicas que el INE lleva a cabo en la actualidad (materiales físicos, flujos físicos de la energía, emisiones a la atmósfera y residuos) por mandato de los respectivos reglamentos comunitarios y en aplicación de las normas metodológicas emanadas de la Oficina de Estadística de la Unión Europea (EUROSTAT). De cada una de ellas, se presenta el marco conceptual, la metodología y estructura, el proceso de elaboración, los principales resultados y finalmente, los indicadores que pueden derivarse de las cuentas.
El Índice de Sociedad Sostenible: Análisis de la situación reciente de la sostenibilidad en el mundo
Authors: Rodríguez-Rosa Miguel , Galindo-Villardón María Purificación , Gallego-Álvarez Isabel
Published: May 2021

Este artículo tiene como objetivo investigar la situación reciente sobre sostenibilidad en países de todo el mundo según el Sustainable Society Index. Se usó la estrategia multivariante del Análisis Parcial Triádico (una generalización del Análisis de Componentes Principales para datos tridimensionales) para analizar las relaciones entre los países e indicadores a lo largo del periodo 2006-2016. Los resultados obtenidos destacan que los indicadores sociales y económicos, como Deuda Pública, están relacionados con países que tienen ingresos más altos, es decir, los países con mayores ingresos prestan más atención a la sostenibilidad social y económica, mientras que los países con ingresos más bajos están más conectados con temas medioambientales. También, con este procedimiento, se puede destacar la posible evolución de los países o indicadores durante el periodo, es decir, podemos ver cómo se comportó cada país respecto a la sostenibilidad a lo largo del tiempo.
Reseña de Padilla (2019), Rupturas y continuidades del teatro en Aguascalientes
Authors: Ortiz Bulle Goyri Alejandro
Published: May 2021

Reseña de Padilla Paredes, Carlos Adrián (2019). Rupturas y continuidades del teatro en Aguascalientes. Instituto Cultural de Aguascalientes.
Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide: an international collaborative study
Authors: Kayser Sabine , Schlenk Richard F. , Lebon Delphine , Carre Martin , Götze Katharina S. , Stölzel Friedrich , Berceanu Ana , Schäfer-Eckart Kerstin , Peterlin Pierre , Hicheri Yosr , Rahme Ramy , Raffoux Emmanuel , Chermat Fatiha , Krause Stefan W. , Aulitzky Walter E. , Rigaudeau Sophie , Noppeney Richard , Berthon Celine , Görner Martin , Jost Edgar , Carassou Philippe , Keller Ulrich , Orvain Corentin , Braun Thorsten , Saillard Colombe , Arar Ali , Kunzmann Volker , Wemeau Mathieu , De Wit Maike , Niemann Dirk , Bonmati Caroline , Schwänen Carsten , Abraham Julie , Aljijakli Ahmad , Haiat Stephanie , Krämer Alwin , Reichle Albrecht , Gnadler Martina , Willekens Christophe , Spiekermann Karsten , Hiddemann Wolfgang , Müller-Tidow Carsten , Thiede Christian , Röllig Christoph , Serve Hubert , Bornhäuser Martin , Baldus Claudia D. , Lengfelder Eva , Fenaux Pierre , Platzbecker Uwe , Adès Lionel
Published: May 2021

The aim of this study was to characterize a large series of 154 patients with acute promyelocytic leukemia (median age, 53 years; range, 18-90 years) and evaluate real-life outcome after up-front treatment with arsenic trioxide and all-trans retinoic acid. All patients were included in the prospective NAPOLEON registry (NCT02192619) between 2013 and 2019. The acute promyelocytic leukemia was de novo in 91% (n=140) and therapy-related in 9% (n=14); 13% (n=20) of the patients were older than 70 years. At diagnosis bleeding/hemorrhage was present in 38% and thrombosis in 3%. Complete remission was achieved in 152 patients (99%), whereas two patients (1%) experienced induction death within 18 days after starting therapy. With a median follow-up of 1.99 years (95% confidence interval: 1.61-2.30 years) 1-year and 2-year overall survival rates were 97% (95% confidence interval: 94-100%) and 95% (95% confidence interval: 91-99%), respectively. Age above 70 years was associated with a significantly shorter overall survival (P<0.001) compared to that of younger patients. So far no relapses have been observed. Six patients (4%) died in complete remission at a median of 0.95 years after diagnosis (range, 0.18-2.38 years). Our data confirm the efficiency and durability of arsenic trioxide and all-trans retinoic acid therapy in the primary management of adults with low-/intermediate-risk acute promyelocytic leukemia in the real-life setting, irrespective of age.
The Potential of Poverty in the City of Palangka Raya: Study SMIs Affected Pandemic Covid 19
Authors: Ningrum Pipit Anggriati , Hukom Alexandra , Adiwijaya Saputra
Published: May 2021

This study aims to analyze the increasing potential for poverty in the city of Palangka Raya from the perspective of SMIs due to the impact of the 19th COVID pandemic. The data was obtained based on the results of in-depth interviews from February to April 2020 with 10 SMIs and supported from secondary data from the Central Statistics Agency. The data is processed based on qualitative research principles based on the type of case study research. In the results of this study it was found that the SMIs experienced a very detrimental impact in terms of sales and marketing of products so that employees who come to work are terminated indefinitely, in this connection it appears that there is potential increases in poverty that can occur in the future come.
Determinant Analysis of Restraint History and Length of Stay (LOS) of Patients with Schizophrenia in Aceh Mental Hospital 2018
Authors: Humaira Humaira , Saputra Irwan , Nurjannah Nurjannah , Usman Said
Published: May 2021

Schizophrenia is classified as serious mental illness (SMI) due to its chronicity. Rumah Sakit Jiwa (RSJ) Aceh is the only referral mental hospital in Aceh Province. The number of inpatient visits in 2018 with a diagnosis of schizophrenia is 2,083 (96.12%). The average length of stay is 59.76 days. The purpose of this study was to determine the relationship between history of restraint and the length of stay (LOS) of schizophrenic patients in the Aceh Mental Hospital in 2018. This study uses quantitative method. Secondary data is collected from the medical records of patients returning home in 2018. The study population was all schizophrenic patients who returned in 2018, thus using the total sampling method. The study reveals that history of restraint influences the length of stay (LOS) of schizophrenic patients in Aceh Mental Hospital in 2018. The patients with restraint history was treated longer that the patients without restraint. Restraint exacerbates the clinical symptoms of Schizophrenia and causes physical abnormalities such as wasting in the extremities so that more time is needed in treatment. To avoid the severity of clinical symptoms, extremities deformation and the length of stay, stakeholders need to take strategic steps to eradicate restraint as a method in the handling of people with mental disorders at the community level.
Management of Slum Settlements based on Sustainable Development in the Deli Watershed of Medan City
Authors: Aldhila Adang , Warsono Hardi , Suwitri Sri , Astuti Retno Sunu
Published: May 2021

The population in urban areas continues to increase while the land owned is limited which results in slum settlements in urban areas. Slum settlements in Medan City often appear in areas where buildings should not be allowed, such as in watersheds. Deli River as a large river that divides Medan City, there are still many slum settlements in the watershed. Management of slum settlements based on sustainable development is needed to provide a long-term impact, especially for the preservation and restoration of the function of the Deli River. This study aims to analyze the management of slum settlements based on sustainable development indicators in achieving sustainable development, namely ecological sustainability, economic sustainability, socio-cultural sustainability, political sustainability, and defense and security sustainability. The research method used is descriptive qualitative. Sources of research data by collecting primary data through interviews and secondary data through documentation and observation studies. The management of slum settlements based on sustainable development in the Deli watershed is still not optimal in terms of ecological sustainability, economic sustainability, and defense and security sustainability. Meanwhile, socio-cultural sustainability and political sustainability are quite optimal. The government must manage slum settlements based on sustainable development through an approach with the community and provide viable housing alternatives so that people do not live in watershed areas.
The Effect of Job Autonomy on Employee Innovative Behavior: The Role of Job Satisfaction as Intervening Variable
Authors: Nasution Nursiha Ramadani , Siregar Zulkifli Musannip Efendi , Pristiyono Pristiyono
Published: May 2021

Employee job satisfaction in covid-19 conditions and situations that need to be considered are those employees who work in Micro, Small, and Medium Enterprises (MSMEs) units. Interestingly, peeling employee job satisfaction in scientific studies is expected to provide various inputs to business managers or business owners who are controlled through work autonomy and innovative behavior in organizations. This research was conducted on the community in the Rantaurapat area around. The questionnaires collected were 100 questionnaires, the respondents in this study were 100 respondents. This research is research using quantitative methods, the researcher in this case distributes questionnaires to get data from respondents using Google Form, and then the data is analyzed using the help of SPSS 23 and AMOS version 23. Based on the results of research and discussion that have been trusted in the previous section, it can be concluded that work autonomy can increase job satisfaction in employees and be able to increase employee innovation behavior. The firm that can provide opportunities for their employees to develop and innovate without feeling pressured at work will provide satisfaction to these employees in working and advancing the company. The results of this study also indicate that job satisfaction did not mediate the effect of job satisfaction on innovation behavior, because the direct effect of job autonomy on innovative behavior was greater than indirect effect via job satisfaction.
The Influence of Work Discipline, Work Ethos and Work Environment on Employee Work Achievement: Lessons from Local Organization in an Emerging Country
Authors: Sipahelut Javed Octovianus , Erari Anita , Rumanta Maman
Published: May 2021

The Office of Industry, Trade, Cooperatives and Small and Medium Enterprises of Yapen Islands Regency, Papua, as a local government agency is obliged to foster, protect, and pay attention to issues related to industry, trade, cooperatives, and small and medium enterprises. Good employee performance is important in order to support the smooth running of official duties. This study aims to examine and analyze the effect of work discipline, work ethic and work environment on employee work performance at the Department of Industry, Trade, Cooperatives and Small and Medium Enterprises, Yapen Islands Regency. Data collection techniques were carried out by distributing questionnaires and interviews. The sample used in this study were 66 respondents. The hypothesis was tested by multiple linear regression analysis with the help of SPSS software. The results of the analysis show that work discipline has a significant positive effect on employee work performance, the higher the level of employee discipline, the higher the work performance. Work ethic has a significant positive effect on employee work performance, the better the work ethic of the employee, the better the work performance. The work environment has a significant positive effect on employee work performance, the better the work environment, the better the employee's work performance.
Features of the wear of the working bodies of the Viking tillage unit
Authors:   VIM, Liskin I.V. , Sidorov S.A. ,   VIM, Mironov D.A. ,   VIM, Mironov A.V. ,   VIM
Published: May 2021

It is shown that the most uniform wear of the bit blade occurs when soil particles move perpendicular to the blade edge. It has been determined that the width of the edge affects the traction resistance of the body, the penetration ability, and the strength of the blade. It has been found that in case of loamy soils, the optimal width of the blade part is in the range between 70 and 80 mm at an acute angle of 50 degrees between the bit blade and the side edge.
Law enforcement practice of regulating freedom of scientific biomedical research in the european union on the example of Germany
Authors: Velychko MV , Radchenko VI
Published: May 2021

Aim. Using the example of Germany, which has an advanced economy and an effective system for ensuring biological safety and biological protection, to study the practice of legal regulation of freedom of scientific research in the EU, in particular in the medical and biological field.

Materials and Methods. Based on the analysis of the legislation of this country, the EU approaches to the creation of a system of regulatory support for this area at the level of development and improvement of the general strategy on biosafety and bioprotection, which is mandatory for implementation in the national programs of the member states, have been analysed. The creation and entry into force of specific regulatory legal acts which in detail administer the procedure for conducting biomedical research work is carried out individually in each participating state, considering national characteristics.

Conclusions. It is proposed for Ukraine when creating an appropriate domestic system to counter bioterrorism, biological sabotage, and other biological threats to use both the positive experience of the EU member states in the development of national programs of biological safety and biological protection as well as regulatory support for their implementation.

Key Words: bioterrorism, bio-threats, bio-risks, biological safety, biological protection
Natural opium products in the modern structure of drug poisoning (literature review and results of drug screening for 1990-2020)
Authors: Kurdil NV
Published: May 2021

Despite the rapid increase in synthetic drug use in the United States, the European Union, and many other parts of the world, narcotic and psychoactive substances of natural origin remain relevant to toxicologists.

Aim. To analyze the results of drug screening of opium drugs in 1990-2020 and their impact on the formation of acute unintentional poisoning among the adult population of Kyiv.

Materials and Мethods. A retrospective analysis of the reports of the toxicological laboratory of the Kyiv City Clinical Emergency Hospital for 1990-2020 on the results of chemical-toxicological screening for drug content in persons diagnosed with "Acute drug poisoning" (ICD-10: T40.0-T40.3). Methods used: Immuno-chromatographic analysis (ICA), thin layer chromatography (TLC) and gas-liquid chromatography with mass spectral detection (GC/MS).

Results. According to official data in Ukraine in 2019, the substances that caused people to seek medical help are distributed as follows: opioids – 68.53%; cannabinoids – 6.84%; cocaine – 0.08%; hallucinogens – 0.04%; other drugs – 24.51%. Among those who died as a result of drug poisoning, the proportion of opiates T40.2 (codeine, morphine) was 16%; opium T40.0 – 4%; methadone T40.3 – 23%; other drugs T40.4 (pethidine) – 2%, which together is 45%. According to the results of chemical-toxicological screening for opiate content, it was found that the first step in the average annual growth rate is occupied by: buprenorphine (+7.95%), morphine (+7.6%) and heroin (+6.04%). The number of positive tests decreased in the group of opiates –"shirka" (–9.38%) and opium alkaloids (–2.55%). Over the last 10 years, there has been a progressive increase in the annual number of positive tests for methadone content (+39.3%) at R 2 =8904, which indicates a high stability of the growth rate.

Conclusions. Opiates continue to occupy an important segment in the structure of drugs, where their positions for the period 1990-2020 strengthened buprenorphine, morphine and heroin against the weakening of the position of opium ("shirka") and opium alkaloids; at the same time there is a rapid increase in the proportion of semisynthetic and synthetic opioids. These changes necessitate continuous improvement of methods of chemical and toxicological studies of opium products, clinical diagnosis and prevention of related poisonings.
Reproductive toxicity of triazole fungicides cyproconazole and epoxiconazole when exposed to male and female wistar rats during gametogenesis
Authors: Shepelskaya NR , Kolyanchuk YaV
Published: May 2021

Aim. Studying the effect of generic pesticides cyproconazole (98 %) and two samples of epoxiconazole (epoxiconazole 1 — 95,75 % and epoxiconazole 2 — 98,7 %) on the reproductive system of male and female Wistar Han rats at the level of the organism when exposed during gametogenesis, identification and characterization of their hazard, as well as assessment of the risk of reproductive toxicity of these compounds. Materials and Methods. The test samples were administered daily (5 days a week) by oral gavage at doses of 0.2 and 2.0 mg/kg for cyproconazole and 0.5 and 2.0 mg/kg for epoxiconazoles during 11 weeks for males, and 10 weeks for females. Also, there were kept intact males and females, intended for crossover mating with experimental animals. After the end of the exposure, functional indicators of the state of the gonads and the ability of animals to reproduce offspring were studied. The duration and the frequency of each stage of the estrous cycle in female rats and the number of motile sperm, the total amount of sperm and the number of abnormal forms of germ cells of the male rats were studied. The reproductive function state in females was evaluated on day 20th of pregnancy. Thereby the number of corpora lutea in the ovaries, number of alive, dead and resorbed foetuses and embryos, the foetus weight, total weight of litters were registered. The studies were carried out in accordance with the recommendations of the Bioethics Commission and the Centre’s standard operating procedures, developed in accordance with the recommendations and requirements of Good Laboratory Practice (GLP).

Conclusions. Test substances at a maximum dose of 2.0 mg/kg of body weight have reproductive toxicity and endocrine-disruptive effect, exerting a significant antiandrogenic effect on males and antiestrogenic effect on female rats. No-observed-adverse-effect-level (NOАEL) for gonadal and reproductive toxicity for male and female Wistar Han rats were established. They are 0.2 mg/kg body weight for cyproconazole and 0.5 mg/kg body weight for epoxiconazole.

Key Words: azole fungicides, cyproconazole, epoxiconazole, reproductive toxicity, antiandrogenic and antiestrogenic effects, Wistar Han rats.