bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of Lymphocyte–CRP Ratio to Conventional Inflammatory Markers for Predicting Clinical Outcomes in COVID-19
Authors: Liu Alexander , Hammond Robert , Chan Kenneth , Chukwuenweniwe Chukwugozie , Johnson Rebecca , Khair Duaa , Duck Eleanor , Olubodun Oluwaseun , Barwick Kristian , Banya Winston , Stirrup James , Donnelly Peter D. , Kaski Juan Carlos , Coates Anthony R. M.
Published: May 2023

Background: In COVID-19 patients, lymphocyte–CRP ratio (LCR) is a promising biomarker for predicting adverse clinical outcomes. How well LCR performs compared to conventional inflammatory markers for prognosticating COVID-19 patients remains unclear, which hinders the clinical translation of this novel biomarker. Methods: In a cohort of COVID-19 inpatients, we characterised the clinical applicability of LCR by comparing its prognostic value against conventional inflammatory markers for predicting inpatient mortality and a composite of mortality, invasive/non-invasive ventilation and intensive care unit admissions. Results: Of the 413 COVID-19 patients, 100 (24%) patients suffered inpatient mortality. On Receiver Operating Characteristics analysis, LCR performed similarly to CRP for predicting mortality (AUC 0.74 vs. 0.71, p = 0.049) and the composite endpoint (AUC 0.76 vs. 0.76, p = 0.812). LCR outperformed lymphocyte counts (AUC 0.74 vs. 0.66, p = 0.002), platelet counts (AUC 0.74 vs. 0.61, p = 0.003) and white cell counts (AUC 0.74 vs. 0.54, p < 0.001) for predicting mortality. On Kaplan–Meier analysis, patients with a low LCR (below a 58 cut-off) had worse inpatient survival than patients with other LCR values (p < 0.001). Conclusion: LCR appears comparable to CRP, but outperformed other inflammatory markers, for prognosticating COVID-19 patients. Further studies are required to improve the diagnostic value of LCR to facilitate clinical translation.
Elementary School First Graders’ Acquisition of Productive L2 French Grammar in Regular and CLIL Programs
Authors: Uhl Patricia , Steinlen Anja K. , Piske Thorsten
Published: May 2023

This study presents productive L2 French grammar data obtained at the end of grade 1 from 186 elementary school children learning French in bilingual (CLIL) or in regular school programs in Germany. The children completed a picture description task to assess their productive oral L2 French grammar skills and two standardized cognitive tests on nonverbal intelligence and sustained attention. The results did not indicate any significant effects of the cognitive tests or of child-internal variables (in this case gender, language background and educational background). However, children in the regular French program unexpectedly outperformed their peers in the bilingual French program. Classroom observations and information provided by teachers suggest that this finding may, at least in part, be due to the fact that in grade 1 there were only minor differences between the two programs in terms of L2 exposure time and teaching methodology.
Aptasensors Are Conjectured as Promising ALT and AST Diagnostic Tools for the Early Diagnosis of Acute Liver Injury
Authors: Chinnappan Raja , Mir Tanveer Ahmad , Alsalameh Sulaiman , Makhzoum Tariq , Adeeb Salma , Al-Kattan Khaled , Yaqinuddin Ahmed
Published: May 2023

Abnormal levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST) in human serum are the most sensitive indicator of hepatocellular damage. Because liver-related health problems are directly linked to elevated levels of ALT and AST, it is important to develop accurate and rapid methods to detect these enzymes for the early diagnosis of liver disease and prevention of long-term liver damage. Several analytical methods have been developed for the detection of ALT and AST. However, these methods are based on complex mechanisms and require bulky instruments and laboratories, making them unsuitable for point-of-care application or in-house testing. Lateral flow assay (LFA)-based biosensors, on the other hand, provide rapid, accurate, and reliable results, are easy to operate, and are affordable for low-income populations. However, due to the storage, stability, batch-to-batch variations, and error margins, antibody-based LFAs are considered unaffordable for field applications. In this hypothesis, we propose the selection of aptamers with high affinity and specificity for the liver biomarkers ALT and AST to build an efficient LFA device for point-of-care applications. Though the aptamer-based LFA would be semiquantitative for ALT and AST, it would be an inexpensive option for the early detection and diagnosis of liver disease. Aptamer-based LFA is anticipated to minimize the economic burden. It can also be used for routine liver function tests regardless of the economic situation in each country. By developing a low-cost testing platform, millions of patients suffering from liver disease can be saved.
Phytase Supplementation of Growing-Finishing Pig Diets with Extruded Soya Seeds and Rapeseed Meal Improves Bone Mineralization and Carcass and Meat Quality
Authors: Buzek Anna , Zaworska-Zakrzewska Anita , Muzolf-Panek Małgorzata , Łodyga Dagmara , Lisiak Dariusz , Kasprowicz-Potocka Małgorzata
Published: May 2023

The aim of this study was to determine how different doses of phytase in diets with extruded soybean seeds and rapeseed meal affected pigs’ growth performance, meat quality, bone mineralization, and fatty acid profiles. Sixty pigs were divided into three treatments by sex and body mass. Pigs were divided into starter (25 days), grower (36 days), and finisher (33 days) periods and fed with mash diets. No phytase was used in the control group diet, whereas in Phy1 and Phy2, 100 g and 400 g of phytase per ton of mixture were used, respectively. The feed conversion ratio and meat color were significantly correlated with phytase. Phytase supplementation had no effect on the growth of pigs, but total phosphorus was significantly increased in the bones and meat of the pigs. The enzyme additive reduced the C22:4 n-6 acid content in the meat, whereas other results were not significantly affected. The data suggest that the addition of phytase at a dosage of 100 g/ton to diets with extruded full-fat soya seeds and rapeseed meal can be valuable, as it reduces the FCR and increases the P content in the meat and bones.
Novel Photodynamic Therapy for Esophageal Squamous Cell Carcinoma following Radiotherapy
Authors: Yanagita Takumi , Hikichi Takuto , Nakamura Jun , Hashimoto Minami , Kato Tsunetaka , Suzuki Rei , Sugimoto Mitsuru , Sato Yuki , Irie Hiroki , Takagi Tadayuki , Kobayakawa Masao , Ohira Hiromasa
Published: May 2023

Radiotherapy (RT) or chemoradiotherapy (CRT) are frequently selected as treatments for esophageal squamous cell carcinoma (ESCC). However, salvage treatment remains challenging when endoscopic resection is not indicated for residual or recurrent ESCC following RT or CRT. Recently, owing to the emergence of second-generation photodynamic therapy (PDT) using talaporfin sodium, PDT can be performed with less phototoxicity and therefore has regained popularity in the treatment of ESCC. In this study, the effectiveness and safety of second-generation PDT in patients with residual or recurrent ESCC following RT or CRT were examined. Local complete response (L-CR) rates, procedure-related adverse events, and prognosis were evaluated. In 12 patients with 20 ESCC lesions, the L-CR rates were 95.0%. Perforation, postoperative bleeding, and photosensitivity were not observed. Esophageal stricture following PDT developed in one patient, but this could be addressed using balloon dilation. During a median follow-up period of 12 (range, 3–42) months, the 3-year cause-specific survival rate was 85.7%. Even in patients with a Charlson comorbidity index score ≥ 3, the 2-year overall survival rates were 100%. In conclusion, PDT was an efficacious and a safe salvage treatment in patients with local residual or recurrent ESCC following RT or CRT.
Book Review: Weiskirchen, R.; Friedman, S.L. Hepatic Stellate Cells: Methods and Protocols, 1st Ed.; Weiskirchen, R., Friedman, S.L., Eds.; Methods in Molecular Biology 2669; Humana Press: New York, NY, USA, 2023; ISBN 978-1-07-163206-2; eISBN: 978-1-0716-3207-9
Authors: Weiskirchen Ralf , Friedman Scott L.
Published: May 2023

Hepatic stellate cells (HSCs) are a liver-specific mesenchymal cell type located in the Dissé space between hepatocytes and sinusoidal endothelial cells [...]
Effects of Maleic Anhydride-Grafted Polyethylene on the Properties of Artificial Marble Waste Powder/Linear Low-Density Polyethylene Composites with Ultra-High Filling Content
Authors: Die Juncheng , Ma Jianting , Li Hai , Zhang Yafeng , Li Fei , Cao Yang , Hao Wanjun , Tu Jinchun , Zhang Kexi , Yu Rentong
Published: May 2023

The need to reach carbon neutrality as soon as possible has made the use of recycled materials widespread. However, the treatment of artificial marble waste powder (AMWP) containing unsaturated polyester is a very challenging task. This task can be accomplished by converting AMWP into new plastic composites. Such conversion is a cost-effective and eco-friendly way to recycle industrial waste. However, the lack of mechanical strength in composites and the low filling content of AMWP have been major obstacles to its practical application in structural and technical buildings. In this study, a composite of AMWP/linear low-density polyethylene (LLDPE) filled with a 70 wt% AMWP content was fabricated using maleic anhydride-grafted polyethylene as a compatibilizer (MAPE). The mechanical strength of the prepared composites is excellent (tensile strength ~18.45 MPa, impact strength ~51.6 kJ/m2), making them appropriate as useful building materials. Additionally, laser particle size analysis, Fourier transform infrared spectroscopy, scanning electron microscopy, energy dispersive X-ray spectroscopy, and thermogravimetric analysis were used to examine the effects of maleic anhydride-grafted polyethylene on the mechanical properties of AMWP/LLDPE composites and its mechanism of action. Overall, this study offers a practical method for the low-cost recycling of industrial waste into high-performance composites.
Composition Design and Tensile Properties of Additive Manufactured Low Density Hf-Nb-Ta-Ti-Zr High Entropy Alloys Based on Atomic Simulations
Authors: Liang Zhuoheng , Wu Yiming , Miao Yu , Pan Wei , Zhang Yongzhong
Published: May 2023

High-entropy alloy (HEA) is a new type of multi-principal alloy material and the Hf-Nb-Ta-Ti-Zr HEAs have attracted more and more attention from researchers due to their high melting point, special plasticity, and excellent corrosion resistance. In this paper, in order to reduce the density of the alloy and maintain the strength of the Hf-Nb-Ta-Ti-Zr HEAs, the effects of high-density elements Hf and Ta on the properties of HEAs were explored for the first time based on molecular dynamics simulations. A low-density and high-strength Hf0.25NbTa0.25TiZr HEA suitable for laser melting deposition was designed and formed. Studies have shown that the decrease in the proportion of Ta element reduces the strength of HEA, while the decrease in Hf element increases the strength of HEA. The simultaneous decrease in the ratio of Hf and Ta elements reduces the elastic modulus and strength of HEA and leads to the coarsening of the alloy microstructure. The application of laser melting deposition (LMD) technology refines the grains and effectively solves the coarsening problem. Compared with the as-cast state, the as-deposited Hf0.25NbTa0.25TiZr HEA obtained by LMD forming has obvious grain refinement (from 300 μm to 20–80 μm). At the same time, compared with the as-cast Hf0.25NbTa0.25TiZr HEA (σs = 730 ± 23 MPa), the as-deposited Hf0.25NbTa0.25TiZr HEA has higher strength (σs = 925 ± 9 MPa), which is similar to the as-cast equiatomic ratio HfNbTaTiZr HEA (σs = 970 ± 15 MPa).
Influence of Isocyanate Structure on Recyclable Shape Memory Poly(thiourethane)
Authors: Zeng Yu , Song Jiale , Li Jinfu , Yuan Chi
Published: May 2023

In this study, poly(thiourethane) (PTU) with different structures is synthesized by click chemistry from trimethylolpropane tris(3-mercaptopropionate) (S3) and different diisocyanates (hexamethylene diisocyanate, HDI, isophorone diisocyanate, IPDI and toluene diisocyanate, TDI). Quantitative analysis of the FTIR spectra reveals that the reaction rates between TDI and S3 are the most rapid, resulting from the combined influence of conjugation and spatial site hindrance. Moreover, the homogeneous cross-linked network of the synthesized PTUs facilitates better manageability of the shape memory effect. All three PTUs exhibit excellent shape memory properties (Rr and Rf are over 90%), and an increase in chain rigidity is observed to negatively impact the shape recovery rate and fix rate. Moreover, all three PTUs exhibit satisfactory reprocessability performance, and an increase in chain rigidity is accompanied by a greater decrease in shape memory and a smaller decrease in mechanical performance for recycled PTUs. Contact angle (<90°) and in vitro degradation results (13%/month for HDI-based PTU, 7.5%/month for IPDI-based PTU, and 8.5%/month for TDI-based PTU) indicate that PTUs can be used as long-term or medium-term biodegradable materials. The synthesized PTUs have a high potential for applications in smart response scenarios requiring specific glass transition temperatures, such as artificial muscles, soft robots, and sensors.
Electronic Structures of Penta-SiC2 and g-SiC3 Nanoribbons: A First-Principles Study
Authors: Liu Zhichao , Liu Xiaobiao , Wang Junru
Published: May 2023

The dimensions of nanoribbons have a significant impact on their material properties. In the fields of optoelectronics and spintronics, one-dimensional nanoribbons exhibit distinct advantages due to their low-dimensional and quantum restrictions. Novel structures can be formed by combining silicon and carbon at different stoichiometric ratios. Using density functional theory, we thoroughly explored the electronic structure properties of two kinds of silicon–carbon nanoribbons (penta-SiC2 and g-SiC3 nanoribbons) with different widths and edge conditions. Our study reveals that the electronic properties of penta-SiC2 and g-SiC3 nanoribbons are closely related to their width and orientation. Specifically, one type of penta-SiC2 nanoribbons exhibits antiferromagnetic semiconductor characteristics, two types of penta-SiC2 nanoribbons have moderate band gaps, and the band gap of armchair g-SiC3 nanoribbons oscillates in three dimensions with the width of the nanoribbon. Notably, zigzag g-SiC3 nanoribbons exhibit excellent conductivity, high theoretical capacity (1421 mA h g−1), moderate open circuit voltage (0.27 V), and low diffusion barriers (0.09 eV), making them a promising candidate for high storage capacity electrode material in lithium-ion batteries. Our analysis provides a theoretical basis for exploring the potential of these nanoribbons in electronic and optoelectronic devices as well as high-performance batteries.
General Atom-Bond Sum-Connectivity Index of Graphs
Authors: Albalahi Abeer M. , Milovanović Emina , Ali Akbar
Published: May 2023

This paper is concerned with the general atom-bond sum-connectivity index ABSγ, which is a generalization of the recently proposed atom-bond sum-connectivity index, where γ is any real number. For a connected graph G with more than two vertices, the number ABSγ(G) is defined as the sum of (1−2(dx+dy)−1)γ over all edges xy of the graph G, where dx and dy represent the degrees of the vertices x and y of G, respectively. For −10≤γ≤10, the significance of ABSγ is examined on the data set of twenty-five benzenoid hydrocarbons for predicting their enthalpy of formation. It is found that the predictive ability of the index ABSγ for the selected property of the considered hydrocarbons is comparable to other existing general indices of this type. The effect of the addition of an edge between two non-adjacent vertices of a graph under ABSγ is also investigated. Furthermore, several extremal results regarding trees, general graphs, and triangle-free graphs of a given number of vertices are proved.
Longitudinal Change in Brain Functional Connectivity with Herpes Zoster Patients: Neuroimaging Case Series
Authors: Kim Changjae , Kim Joongbaek , Chang Hyunjae , Hong Dakyung , Hong Sanghyun , Moon Hosik
Published: May 2023

The exact mechanism involved in the development of postherpetic neuralgia (PHN) is not yet known. The objective of this study was to evaluate longitudinal functional connectivity (FC) changes in the neuroimaging case series of patients with acute herpes zoster (HZ). Cases: This study included five patients who had symptoms of HZ. Functional magnetic resonance imaging was conducted at enrollment and 3 months to determine FC changes. Of the five patients, three developed PHN. In the PHN subjects, the FC of the left superior frontal gyrus (SFG) and the right inferior frontal gyrus (IFG) were activated. The left SFG is known to contribute to higher cognitive functions and working memory. The right IFG is associated with pain processing and empathy for pain. Conclusions: Although only a few patients were enrolled in this study, the PHN could be affected by pain itself, as well as pain memory and psychological aspects such as empathy for pain.
Advanced Membrane Technologies for Wastewater Treatment and Recycling
Authors: Lin Hongjun , Zhang Meijia
Published: May 2023

In the face of the ever-growing severe problem of water scarcity, wastewater reuse, recycling and resource recovery are increasingly recognized as crucial part of the solution [...]
Pore-Scale Modeling of Liquid Water Transport in Compressed Gas Diffusion Layer of Proton Exchange Membrane Fuel Cells Considering Fiber Anisotropy
Authors: Wang Hao , Yang Guogang , Li Shian , Shen Qiuwan , Li Yue , Wang Renjie
Published: May 2023

Water management of the gas diffusion layer (GDL) is crucial to the performance of proton exchange membrane fuel cells (PEMFCs). Appropriate water management ensures efficient transport of reactive gases and maintains wetting of the proton exchange membrane to enhance proton conduction. In this paper, a two-dimensional pseudo-potential multiphase lattice Boltzmann model is developed to study liquid water transport within the GDL. Liquid water transport from the GDL to the gas channel is the focus, and the effect of fiber anisotropy and compression on water management is evaluated. The results show that the fiber distribution approximately perpendicular to the rib reduces liquid water saturation within the GDL. Compression significantly changes the microstructure of the GDL under the ribs, which facilitates the formation of liquid water transport pathways under the gas channel, and the increase in the compression ratio leads to a decrease in liquid water saturation. The performed microstructure analysis and the pore-scale two-phase behavior simulation study comprise a promising technique for optimizing liquid water transport within the GDL.
Machining: State-of-the-Art 2022
Authors: Silva Francisco J. G. , Fernandes Filipe , Sousa Vitor F. C.
Published: May 2023

Although additive manufacturing is gaining prominence in the market, many applications require very high levels of precision, which are currently not attainable by additive manufacturing [...]
Metabolic Characteristics of Frail Older People with Diabetes Mellitus—A Systematic Search for Phenotypes
Authors: Abdelhafiz Ahmed H. , Keegan Grace L. , Sinclair Alan J.
Published: May 2023

Frailty in older people with diabetes is viewed as one homogeneous category. We previously suggested that frailty is not homogeneous and spans across a metabolic spectrum that starts with an anorexic malnourished (AM) frail phenotype and ends with a sarcopenic obese (SO) phenotype. We aimed to investigate the metabolic characteristics of frail older people with diabetes reported in the current literature to explore whether they fit into two distinctive metabolic phenotypes. We performed systematic review of studies published over the last 10 years and reported characteristics of frail older people with diabetes mellitus. A total of 25 studies were included in this systematic review. Fifteen studies reported frail patients’ characteristics that could fit into an AM phenotype. This phenotype is characterised by low body weight, increased prevalence of malnutrition markers such as low serum albumin, low serum cholesterol, low Hb, low HbA1c, and increased risk of hypoglycaemia. Ten studies reported frail patients’ characteristics that describe a SO phenotype. This phenotype is characterised by increased body weight, increased serum cholesterol, high HbA1c, and increased blood glucose levels. Due to significant weight loss in the AM phenotype, insulin resistance decreases, leading to a decelerated diabetes trajectory and reduced hypoglycaemic agent use or deintensification of therapy. On the other hand, in the SO phenotype, insulin resistance increases leading to accelerated diabetes trajectory and increased hypoglycaemic agent use or intensification of therapy. Current literature suggests that frailty is a metabolically heterogeneous condition that includes AM and SO phenotypes. Both phenotypes have metabolically distinctive features, which will have a different effect on diabetes trajectory. Therefore, clinical decision-making and future clinical studies should consider the metabolic heterogeneity of frailty.
Sustainable Dry Machining of Stainless Steel with Microwave-Treated Tungsten Carbide Cutting Tools
Authors: Babe Itemogeng Bernatt , Gupta Kapil , Chaubey Sujeet Kumar
Published: May 2023

This paper presents a research investigation conducted on the turning of stainless steel 316 material under a dry environment using microwave-treated cutting tool inserts. Plain tungsten carbide WC tool inserts were exposed to microwave treatment for enhancement of their performance characteristics. It was found that a 20-min microwave treatment resulted in the best tool hardness and metallurgical characteristics. These tool inserts have been used to machine SS 316 material following the Taguchi L9 design of experimental techniques. A total of eighteen experiments have been conducted by varying three main machining parameters, i.e., cutting speed, feed rate, and depth of cut, at three levels per parameter. It has been found that tool flank wear increased with all three parameters and surface roughness decreased. At the longest dept of cut, surface roughness increased. An abrasion wear mechanism was found on the tool flank face at a high machining speed and adhesion at low speed. Chips with a helical shape and low serrations have been investigated. Turning SS 316 at optimum machining parameters of 170 m/min cutting speed, 0.2 mm/rev feed rate, and 1 mm depth of cut, as obtained by the multiperformance optimization technique grey relational analysis, resulted in the best values of all machinability indicators: 242.21 µm tool flank wear, 3.81 µm mean roughness depth, and 34,000 mm3/min material removal rate, at a single parameter setting. In terms of research achievements, the percentage reduction in surface roughness is approximately 30% and represents an almost ten-fold improvement in the material removal rate. The combination of machining parameters of 70 m/min cutting speed, 0.1 mm/rev feed rate, and 0.5 mm depth of cut is optimum for the lowest value of tool flank wear when considered for single parameter optimization.
Saliva Decreases Sucrose-Induced Cariogenicity in an Experimental Biological Caries Model
Authors: Giacaman Rodrigo A. , Umaña Rodrigo , Nuñez María José , Díaz-Garrido Natalia , Echeverría Constanza , García-Manríquez Natalia , Mira Alex , Fernández Constanza E. , Gambetta-Tessini Karla , Lozano Carla P.
Published: May 2023

Objective. Whether a minimum quantity of saliva inhibit the caries process remains uncertain. This study aimed to investigate the impact of saliva dilutions on an in vitro caries model using Streptococcus mutans (S. mutans) biofilms. Methods. S. mutans biofilms were cultivated on enamel and root dentin slabs, in culture media containing different proportions of saliva (v/v): 0%, 5%, 10%, 25%, 50%, 75%, and 100% saliva, and exposed to a 10% sucrose solution (5 min, 3x/day), with appropriate controls. After 5 (enamel) and 4 (dentin) days, demineralization, biomass, viable bacteria, and polysaccharide formation were analyzed. The acidogenicity of the spent media was monitored overtime. Each assay was performed in triplicate across two independent experiments (n = 6). Results. In both enamel and dentin, an inverse relationship was observed between acidogenicity, demineralization, and the proportion of saliva. Even small quantities of saliva incorporated into the media led to a noticeable reduction in enamel and dentin demineralization. Saliva presence resulted in significant reductions in biomass, viable S. mutans cells, and polysaccharides, with the effects being concentration-dependent for both tissues. Conclusions. High quantities of saliva can almost completely inhibit sucrose-induced cariogenicity, while even small amounts exhibit a dose-dependent caries-protective effect.
Antimicrobial Activity of Spanish Propolis against Listeria monocytogenes and Other Listeria Strains
Authors: Rendueles Eugenia , Mauriz Elba , Sanz-Gómez Javier , Adanero-Jorge Félix , García-Fernandez Camino
Published: May 2023

The outbreaks of Listeria associated with food consumption are increasing worldwide concurrently with public concern about the need for natural growth inhibitors. In this context, propolis seems to be a promising bioactive product collected by honeybees, due to its antimicrobial activity against different food pathogens. This study aims to evaluate the efficacy of hydroalcoholic propolis extracts for controlling Listeria under several pH conditions. The physicochemical properties (wax, resins, ashes, impurities), the bioactive compounds (phenolic and flavonoid content), and the antimicrobial activity of 31 propolis samples collected from the half North of Spain were determined. Results showed similar trends in the physicochemical composition and bioactive properties, regardless of the harvesting area. Non-limiting pH conditions (7.04, 6.01, 5.01) in 11 Listeria strains (5 from collection and 6 wild strains from meat products) exhibited MICs (Minimum inhibition concentration) and MBCs (Minimum bactericidal concentration) ranging from 39.09 to 625 μg/mL. The antibacterial activity increased under acidic pH conditions, showing a synergistic effect at pH = 5.01 (p < 0.05). These findings suggest the potential of Spanish propolis as a natural antibacterial inhibitor to control Listeria growth in food products.
Geochronology and Petrogenesis of the Early Paleozoic Jilongjie Granites in the Central South China Block: Implication for Post-Kinematic Lithospheric Delamination
Authors: He Haiyang , Wang Tingting , Sui Qinglin , Duan Xianzhe , Ren Xuan , Hou Danping , Xie Yanshi , Liu Shan , Feng Peng , Zhang Huanbao , Chen Liang
Published: May 2023

Controversy over the geodynamic interpretation of the early Paleozoic granites in the South China Block constrains understanding of tectonic–magmatic evolution. In this paper, we present zircon U-Pb age, Hf isotope, and major and trace element data of the early Paleozoic granites in the Jilongjie region, south-central Hunan Province. A sample that yielded a weighted average 206Pb/238U age of 425 ± 3 Ma falls into the post-collisional granite field in the classification discriminant of magmatic rocks. Geochemical features indicate that the Jilongjie pluton is a shoshonitic metaluminous rock. The Jilongjie pluton’s chondrite-normalized rare earth element patterns exhibit a slight enrichment of light rare earth elements (LREEs) relative to heavy rare earth elements (HREEs) with (La/Yb)N ratios of 15.1–23.7 and weak Eu anomalies (Eu/Eu* = 0.68–0.78). Zircon Hf isotope results show εHf(t) ranging from −9.94 to −0.69. Jilongjie granite’s parent magma originated from a mixing of crust-derived felsic and mantle-derived mafic magmas, which then underwent fractional crystallization during its ascent. Jilongjie granite was generated through a post-collisional extensional setting associated with delamination of the thickened lithosphere.
Ce and Nd Extraction by Cationic Exchange, Using Bentonite, Diatomite, and Eggshell—Preliminary Study
Authors: Salinas Rodríguez Eleazar , Cárdenas-Reyes Edgar A. , Barrientos-Hernández Francisco R. , Flores-Badillo Javier , Gutiérrez-Amador M. P. , Sánchez-Castillo Ariadna , Acevedo-Sandoval Otilio A. , Cerecedo-Sáenz Eduardo , Hernández-Ávila Juan
Published: May 2023

China, Vietnam, Brazil, and Russia have the largest deposits of rare earths. However, in recent works, the occurrence of light rare earth elements has been demonstrated in an exhalative sedimentary type mineral (SEDEX) in Mexico, with adequate Ce and Nd contents. Additionally, it is this mineral that has been used to study the cation exchange capacity of non-metallic minerals and organic materials, such as bentonite, diatomite, and eggshell. To carry out this work, the crushed and ground SEDEX ore was leached using HCl, H2SO4, and HNO3. Subsequently, the liquid containing the Ce and Nd ions extracted from the mineral was put in contact with the respective ion exchangers, evaluating the effect of temperature and pH to determine the cation exchange efficiency of each exchanger tried. It was found that the best leaching results were achieved with the H2SO4, obtaining an extraction of Ce and Nd of 97.6% and 95.7%, respectively. On the other hand, in the case of cation exchange, the best results found for the extraction of Ce and Nd were using diatomite at a temperature of 323 K and a pH of 3, obtaining an extraction of 99.06% Ce and 99.07% Nd.
Neuromorphic Photonics Based on Phase Change Materials
Authors: Li Tiantian , Li Yijie , Wang Yuteng , Liu Yuxin , Liu Yumeng , Wang Zhan , Miao Ruixia , Han Dongdong , Hui Zhanqiang , Li Wei
Published: May 2023

Neuromorphic photonics devices based on phase change materials (PCMs) and silicon photonics technology have emerged as promising solutions for addressing the limitations of traditional spiking neural networks in terms of scalability, response delay, and energy consumption. In this review, we provide a comprehensive analysis of various PCMs used in neuromorphic devices, comparing their optical properties and discussing their applications. We explore materials such as GST (Ge2Sb2Te5), GeTe-Sb2Te3, GSST (Ge2Sb2Se4Te1), Sb2S3/Sb2Se3, Sc0.2Sb2Te3 (SST), and In2Se3, highlighting their advantages and challenges in terms of erasure power consumption, response rate, material lifetime, and on-chip insertion loss. By investigating the integration of different PCMs with silicon-based optoelectronics, this review aims to identify potential breakthroughs in computational performance and scalability of photonic spiking neural networks. Further research and development are essential to optimize these materials and overcome their limitations, paving the way for more efficient and high-performance photonic neuromorphic devices in artificial intelligence and high-performance computing applications.
Effects of Coulomb Blockade on the Charge Transport through the Topological States of Finite Armchair Graphene Nanoribbons and Heterostructures
Authors: Kuo David M. T.
Published: May 2023

In this study, we investigate the charge transport properties of semiconducting armchair graphene nanoribbons (AGNRs) and heterostructures through their topological states (TSs), with a specific focus on the Coulomb blockade region. Our approach employs a two-site Hubbard model that takes into account both intra- and inter-site Coulomb interactions. Using this model, we calculate the electron thermoelectric coefficients and tunneling currents of serially coupled TSs (SCTSs). In the linear response regime, we analyze the electrical conductance (Ge), Seebeck coefficient (S), and electron thermal conductance (κe) of finite AGNRs. Our results reveal that at low temperatures, the Seebeck coefficient is more sensitive to many-body spectra than electrical conductance. Furthermore, we observe that the optimized S at high temperatures is less sensitive to electron Coulomb interactions than Ge and κe. In the nonlinear response regime, we observe a tunneling current with negative differential conductance through the SCTSs of finite AGNRs. This current is generated by electron inter-site Coulomb interactions rather than intra-site Coulomb interactions. Additionally, we observe current rectification behavior in asymmetrical junction systems of SCTSs of AGNRs. Notably, we also uncover the remarkable current rectification behavior of SCTSs of 9-7-9 AGNR heterostructure in the Pauli spin blockade configuration. Overall, our study provides valuable insights into the charge transport properties of TSs in finite AGNRs and heterostructures. We emphasize the importance of considering electron–electron interactions in understanding the behavior of these materials.
Effective Interventions in Obesity: Current Evidence and Concepts
Authors: Szewczyk-Golec Karolina , Hołyńska-Iwan Iga
Published: May 2023

This Special Issue, entitled “Specialized Diet, Obesity and Associated Metabolic Disorders” in the section “Clinical Nutrition” of Nutrients, addresses the metabolic changes that occur in humans as a result of the so-called western lifestyle [...]
Dietary Interventions in Obesity and Metabolic Syndrome
Authors: Szewczyk-Golec Karolina , Hołyńska-Iwan Iga
Published: May 2023

Here, we present a Special Issue of Nutrients entitled “Specialized Diet, Obesity and Associated Metabolic Diseases” containing up-to-date scientific data important to both researchers and the public [...]
Athlete Preferences for Nutrition Education: Development of and Findings from a Quantitative Survey
Authors: Solly Hayley , Badenhorst Claire E. , McCauley Matson , Slater Gary J. , Gifford Janelle A. , Erueti Bevan , Beck Kathryn L.
Published: May 2023

Nutrition education (NE) is one of several strategies aimed at enhancing the dietary intake of athletes. This study investigated NE preferences of New Zealand and Australian athletes competing nationally and internationally. Athletes (n = 124, 22 (18, 27) years, female 54.8%) from 22 sports completed an online survey, with responses analysed using descriptive statistics. Teaching techniques considered ‘extremely effective’ were life examples (47.6% of athletes), hands-on activities (30.6%), and discussions with a facilitator (30.6%). Setting personal nutrition goals was important to most athletes (83.9%), along with two-way feedback with a facilitator (75.0%). General nutrition topics considered ‘essential’ were energy requirements (52.9%), hydration (52.9%), and nutrient deficiencies (43.3%). Performance topics considered ‘essential’ were recovery (58.1%), pre-exercise nutrition (51.6%), nutrition during exercise (50.0%), and energy requirements for training (49.2%). Athletes preferred a ‘combination of in-person group and one-on-one sessions’ (25% of athletes), ‘one-on one sessions’ (19.2%) and ‘in-person group sessions’ (18.3%), with only 13.3% interested in ‘exclusively online delivery’. Sessions of 31–60 min (61.3% of athletes) held monthly (37.5%) and undertaken with athletes of the same sporting calibre (61.3%) were favoured by the participants. The preferred facilitator was a performance dietitian or nutritionist (82.1% of athletes), who had knowledge of the sport (85.5%), experience in sports nutrition (76.6%), and credibility (73.4%). This research provides novel insights into the factors that need to be considered when designing and implementing nutrition education for athletes.
Effects of Diet—Exercise Interaction on Human Health across a Lifespan
Authors: Moradell Ana , Casajús José Antonio , Moreno Luis A. , Vicente-Rodríguez Germán , Gómez-Cabello Alba
Published: May 2023

The world is changing even faster than ever and has modified people’s lives [...]
Type 2 Diabetes Mellitus and Liver Disease: Across the Gut–Liver Axis from Fibrosis to Cancer
Authors: Manilla Vittoria , Santopaolo Francesco , Gasbarrini Antonio , Ponziani Francesca Romana
Published: May 2023

Type 2 diabetes mellitus is a widespread disease worldwide, and is one of the cornerstones of metabolic syndrome. The existence of a strong relationship between diabetes and the progression of liver fibrosis has been demonstrated by several studies, using invasive and noninvasive techniques. Patients with type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease (NAFLD) show faster progression of fibrosis than patients without diabetes. Many confounding factors make it difficult to determine the exact mechanisms involved. What we know so far is that both liver fibrosis and T2DM are expressions of metabolic dysfunction, and we recognize similar risk factors. Interestingly, both are promoted by metabolic endotoxemia, a low-grade inflammatory condition caused by increased endotoxin levels and linked to intestinal dysbiosis and increased intestinal permeability. There is broad evidence on the role of the gut microbiota in the progression of liver disease, through both metabolic and inflammatory mechanisms. Therefore, dysbiosis that is associated with diabetes can act as a modifier of the natural evolution of NAFLD. In addition to diet, hypoglycemic drugs play an important role in this scenario, and their benefit is also the result of effects exerted in the gut. Here, we provide an overview of the mechanisms that explain why diabetic patients show a more rapid progression of liver disease up to hepatocellular carcinoma (HCC), focusing especially on those involving the gut–liver axis.
Effectiveness of Lifestyle Nutrition and Physical Activity Interventions for Childhood Obesity and Associated Comorbidities among Children from Minority Ethnic Groups: A Systematic Review and Meta-Analysis
Authors: Obita George , Alkhatib Ahmad
Published: May 2023

Lifestyle physical activity (PA) and nutrition are known to be effective interventions in preventing and managing obesity-related comorbidities among adult populations but less so among children and adolescents. We examined the effectiveness of lifestyle interventions in children from minority ethnic populations in Western high-income countries (HICs). Our systematic review included 53 studies, involving 26,045 children from minority ethnic populations who followed lifestyle intervention programmes lasting between 8 weeks and 5 years with the aim of preventing and/or managing childhood obesity and associated comorbidities, including adiposity and cardiometabolic risks. The studies were heterogenous in terms of lifestyle intervention components (nutrition, PA, behavioural counselling) and settings (community vs. schools and after-school settings). Our meta-analysis included 31 eligible studies and showed no significant effects of lifestyle interventions when they focused on body mass index (BMI) outcomes (pooled BMI mean change = −0.09 (95% CI = −0.19, 0.01); p = 0.09). This was irrespective of the intervention programme duration (<6 months vs. ≥6 months), type (PA vs. nutrition/combined intervention) and weight status (overweight or obese vs. normal weight) as all showed nonsignificant effects in the sensitivity analysis. Nonetheless, 19 of the 53 studies reported reductions in BMI, BMI z-score and body fat percentage. However, the majority of lifestyle interventions adopting a quasi-design with combined primary and secondary obesity measures (11 out of 15 studies) were effective in reducing the obesity comorbidities of cardiometabolic risks, including metabolic syndrome, insulin sensitivity and blood pressure, in overweight and obese children. Preventing childhood obesity in high-risk ethnic minority groups is best achieved using combined PA and nutrition intervention approaches, which jointly target preventing obesity and its comorbidities, especially the outcomes of diabetes, hypertension and cardiovascular disease. Therefore, public health stakeholders should integrate cultural and lifestyle factors and contextualise obesity prevention strategies among minority ethnic groups in Western HICs.
Effect of Oral Nutritional Supplementation on Adequacy of Nutrient Intake among Picky-Eating Children at Nutritional Risk in India: A Randomized Double Blind Clinical Trial
Authors: Anwar Fahmina , Yalawar Menaka , Suryawanshi Pranali , Ghosh Apurba , Jog Pramod , Khadilkar Anuradha Vaman , Kishore Bala , Paruchuri Anil Kumar , Pote Prahalad D. , Mandyam Ravi D. , Shinde Sandeep , Shah Atish
Published: May 2023

Nutrient inadequacies among picky-eaters have adverse effects on growth and development. Oral nutritional supplements (ONS) along with dietary counseling (DC), rather than DC alone as reported in our earlier publication, promoted growth among picky-eating Indian children aged from >24 m to ≤48 m with weight-for-height percentiles lying between the 5th and 25th (based on WHO Growth Standards) over 90 days. This paper presents the contribution of ONS to nutrient adequacy, dietary diversity, and food consumption patterns in children (N = 321). Weight, height, and dietary intakes, using 24-h food recalls, were measured at baseline (Day 1) and at Days 7, 30, 60, and 90. Nutrient adequacy, dietary diversity score (DDS), and food intake adequacy were calculated in both the supplementation groups (ONS1 + DC and ONS2 + DC; n = 107 in each group) and the control group (DC-only; n = 107). Supplements increased nutrient adequacy in both of the ONS + DC groups relative to control (p < 0.05). The proportions of children with adequate nutrient intakes increased significantly at Day 90 in the supplemented groups as compared to in the control group (p < 0.05), especially for total fat, calcium, vitamin A, vitamin C, and thiamin. Although no significant differences were observed in DDS in any of the groups, the percentage of children consuming ≥4 food groups in a day had increased in all the groups. Consumption of fruit and vegetables and cereals had increased significantly from baseline to Day 90. ONS along with dietary counseling was found to have improved nutritional adequacy without interfering with the normal food consumption patterns of picky-eating children at nutritional risk.
Relationship between Gut Microbiota and Allergies in Children: A Literature Review
Authors: Pantazi Alexandru Cosmin , Mihai Cristina Maria , Balasa Adriana Luminita , Chisnoiu Tatiana , Lupu Ancuta , Frecus Corina Elena , Mihai Larisia , Ungureanu Adina , Kassim Mustafa Ali Kassim , Andrusca Antonio , Nicolae Maria , Cuzic Viviana , Lupu Vasile Valeriu , Cambrea Simona Claudia
Published: May 2023

The intestinal microbiota is a diverse and complex microecosystem that lives and thrives within the human body. The microbiota stabilizes by the age of three. This microecosystem plays a crucial role in human health, particularly in the early years of life. Dysbiosis has been linked to the development of various allergic diseases with potential long-term implications. Next-generation sequencing methods have established that allergic diseases are associated with dysbiosis. These methods can help to improve the knowledge of the relationship between dysbiosis and allergic diseases. The aim of this review paper is to synthesize the current understanding on the development of the intestinal microbiota in children, the long-term impact on health, and the relationship between dysbiosis and allergic diseases. Furthermore, we examine the connection between the microbiome and specific allergies such as atopic dermatitis, asthma, and food allergies, and which mechanisms could determine the induction of these diseases. Furthermore, we will review how factors such as mode of delivery, antibiotic use, breastfeeding, and the environment influence the development of the intestinal flora, as well as review various interventions for the prevention and treatment of gut microbiota-related allergies.
Ion Channels and Personalized Medicine in Gynecological Cancers
Authors: Ramírez Ana , Ogonaga-Borja Ingrid , Acosta Brenda , Chiliquinga Andrea Jazmín , de la Garza Jaime , Gariglio Patricio , Ocádiz-Delgado Rodolfo , Bañuelos Cecilia , Camacho Javier
Published: May 2023

Targeted therapy against cancer plays a key role in delivering safer and more efficient treatments. In the last decades, ion channels have been studied for their participation in oncogenic processes because their aberrant expression and/or function have been associated with different types of malignancies, including ovarian, cervical, and endometrial cancer. The altered expression or function of several ion channels have been associated with tumor aggressiveness, increased proliferation, migration, invasion, and metastasis of cancer cells and with poor prognosis in gynecological cancer patients. Most ion channels are integral membrane proteins easily accessible by drugs. Interestingly, a plethora of ion channel blockers have demonstrated anticancer activity. Consequently, some ion channels have been proposed as oncogenes, cancer, and prognostic biomarkers, as well as therapeutic targets in gynecological cancers. Here, we review the association of ion channels with the properties of cancer cells in these tumors, which makes them very promising candidates to be exploited in personalized medicine. The detailed analysis of the expression pattern and function of ion channels could help to improve the clinical outcomes in gynecological cancer patients.
Recent Advances in Doxorubicin Formulation to Enhance Pharmacokinetics and Tumor Targeting
Authors: Lee Jihoon , Choi Min-Koo , Song Im-Sook
Published: May 2023

Doxorubicin (DOX), a widely used drug in cancer chemotherapy, induces cell death via multiple intracellular interactions, generating reactive oxygen species and DNA-adducted configurations that induce apoptosis, topoisomerase II inhibition, and histone eviction. Despite its wide therapeutic efficacy in solid tumors, DOX often induces drug resistance and cardiotoxicity. It shows limited intestinal absorption because of low paracellular permeability and P-glycoprotein (P-gp)-mediated efflux. We reviewed various parenteral DOX formulations, such as liposomes, polymeric micelles, polymeric nanoparticles, and polymer-drug conjugates, under clinical use or trials to increase its therapeutic efficacy. To improve the bioavailability of DOX in intravenous and oral cancer treatment, studies have proposed a pH- or redox-sensitive and receptor-targeted system for overcoming DOX resistance and increasing therapeutic efficacy without causing DOX-induced toxicity. Multifunctional formulations of DOX with mucoadhesiveness and increased intestinal permeability through tight-junction modulation and P-gp inhibition have also been used as orally bioavailable DOX in the preclinical stage. The increasing trends of developing oral formulations from intravenous formulations, the application of mucoadhesive technology, permeation-enhancing technology, and pharmacokinetic modulation with functional excipients might facilitate the further development of oral DOX.