bluuebunny/crossref_metadata_2025 huggingface dataset:
Mental Health and Self-Determination Profiles of the Diverse Population of Medical Students in Malaysia During the COVID-19 Pandemic
Authors: Cockburn Jessica , Tan Chee Yang , Poh Dawn Celine Siaw Chern , Tan Ding Jun , Foong Chan Choong , Hong Wei-Han
Published: December 2021

Introduction: Medical schools throughout the world were forced to modify their programming during the COVID-19 pandemic. In Malaysia, virtual learning plans were implemented for non-clinical programming, while clinical posting modifications were designed to meet local SOPs. The prolonged enforcement of these modifications to undergraduate medical education will have affected student experiences, including well-being. Since these feelings can relate to perceived relatedness, autonomy, and competence, it is important to identify any potential factors that may lead to reduced intrinsic motivation in students. It is also important to consider how demographic features may contribute to student perspectives, which can be studied using the unique diversity represented by Malaysian students.Methods: A quantitative survey was distributed to Malaysian medical students to assess their overall wellbeing, autonomy in educational decision making, student experiences, and position on changes to graduation timing. Intrinsic components were identified using Principal Component Analysis and were aligned with the three needs for self-determination, namely relatedness, autonomy, and competence. Finally, trends in responses for participants from various sub-populations were assessed using ANOVA testing. Results: Responses were collected from 442 students representing 23 accredited Malaysian medical schools. Upon validation and reliability testing, eight components were identified with themes relating to: mental health, social concerns, communication, timing of modifications, depth of learning, and student-centred learning. Of these, gender was related to mental health, student-centred learning, and delayed graduation, while stage was related to student-centred learning and delayed graduation in addition to concerns about depth of learning and timing of modifications. Interestingly, ethnicity was related to differences in opinions about delayed graduation and income was related to social concerns. Conclusion: The results of this study indicate that, while students were satisfied in general with the content and delivery of their programmes given the circumstances, there is evidence to suggest negative effects on emotional wellbeing, expression of student voice, due to the modifications that were made. Additionally, these feelings related to the three motivational needs, suggesting that students were experiencing a dampened motivational profile during the pandemic. Further, motivational profiles were distinct between student sub-groups, providing insight for developing appropriate and inclusive accommodations moving forward.
Mechanism of replication fork reversal and protection by human RAD51 and RAD51 paralogs
Authors: Cejka Petr , Halder Swagata , Sanchez Aurore , Ranjha Lepakshi , Taglialatela Angelo , Reginato Giordano , Ceppi Ilaria , Acharya Ananya , Anand Roopesh , Ciccia Alberto
Published: December 2021

SMARCAL1, ZRANB3 and HLTF are all required for the remodeling of replication forks upon stress. Using reconstituted reactions, we show that the motor proteins have unequal biochemical capacities, explaining why they have non-redundant functions. Whereas SMARCAL1 uniquely anneals RPA-coated ssDNA, suggesting an initial function in fork reversal, it becomes comparatively inefficient in subsequent branch migration. We also show that low concentrations of RAD51 and the RAD51 paralog complex, RAD51B-RAD51C-RAD51D-XRCC2 (BCDX2), directly stimulate SMARCAL1 and ZRANB3 but not HLTF, providing a mechanism underlying previous cellular data implicating these factors in fork reversal. Upon reversal, RAD51 protects replication forks from degradation by MRE11, DNA2 and EXO1 nucleases. We show that the protective function of RAD51 unexpectedly depends on its binding to double-stranded DNA, and higher RAD51 concentrations are required for DNA protection compared to reversal. Together, we define the non-canonical functions of RAD51 and its paralogs in replication fork reversal and protection.
Identification of Molecular Biomarkers Associated with Non-Small-Cell Lung Carcinoma (NSCLC) Using Whole-Exome Sequencing Analysis
Authors: Singh Varsha , Katiyar Amit , Malik Prabhat , Kumar Sunil , Mohan Anant , Singh Harpreet , Jain Deepali
Published: December 2021

Significant advancement has been made in the treatment of patients with on the basis of the molecular profile. However, no such molecular target exists for squamous cell carcinoma (SQCC). Whole-exome sequencing (WES) has been in wide use for the discovery of new genetic pulmonary adenocarcinoma (ADCA) markers, which may offer more information for the development of personalized medicine for all subtypes of lung cancer. The aim of the current study is to find out novel genetic markers for non-small-cell lung carcinoma (NSCLC). WES of 19 advanced NSCLC patients (10 ADCA and 9 SQCC) was done on the Illumina HiSeq 2000 (Illumina Inc., USA). Variant calling was performed using GATK HaplotypeCaller and subsequent the impacts of variants on protein structure or function were predicted using SnpEff and ANNOVAR. Clinical impact of variants was evaluated using cancer-related archives. Somatic variants were further prioritized using knowledge-driven variant interpretation approach. Functionally important variants were validated by Sanger sequencing. We identified 24 rare single-nucleotide variants (SNVs) including 17 non-synonymous SNVs, and 7 INDELs in 18 genes possibly linked to lung carcinoma. Sanger sequencing of 10 high confidence somatic SNVs showed 100% concordance in 7 genes, whereas 80% in the remaining 3 genes. Our bioinformatics analysis identified KCNJ18, GPRIN2, TEKT4, HRNR, FOLR3, ESSRA, CTBP2, MPRIP, TBP, and FBXO6 may contribute to progression in NSCLC and could be used as new biomarkers for the treatment. Although the mechanism of GPRIN2, KCNJ12 and TEKT4 in tumorigenesis is unclear; our results suggest that these may play a major role in NSCLC and it is worth investigating in future.
Fine Mapping and Analysis of Candidate Genes for qFT7.1, a Major Quantitative Trait Locus Controlling Flowering Time in Brassica Rapa L
Authors: Qu Gaoyang , Gao Yue , Wang Xian , Fu Wei , Sun Yunxia , Gao Xu , Wang Wei , Hao Chunming , Feng Hui , Wang Yugang
Published: December 2021

In Brassica rapa, flowering time (FT) is an important agronomic trait that affects the yield, quality, and adaption. FT a complicated trait that is regulated by many genes and is affected greatly by the environment. In this study, a chromosome segment substitution line (CSSL), CSSL16, was selected that showed later flowering than the recurrent parent, rapid-cycling inbred line of B. rapa (RcBr). Using Bulked Segregant RNA sequencing, we identified a late flowering quantitative trait locus (QTL), designated as qFT7.1, on chromosome A07 based on a secondary-F2 population derived from the cross between CSSL16 and RcBr. qFT7.1 was further validated by conventional QTL mapping. This QTL explained 39.9% (logarithm of odds = 32.2) of the phenotypic variations and was fine mapped to a 56.4-kb interval using recombinant analysis. Expression analysis suggests that BraA07g018240.3C, which is homologous with ATC (encoding Arabidopsis thaliana CENTRORADIALIS homologue), a gene for delayed flowering in Arabidopsis as the most promising candidate gene. Sequence analysis demonstrated that two synonymous mutations existed in the coding region and numerous bases replacements existed in promoter region between BraA07g018240.3C from CSSL16 and RcBr. The results will increase our knowledge related to the molecular mechanism of late flowering in B. rapa, and lay a solid foundation for the breeding of late bolting in B. rapa.
Overexpression of Shinorhizobium Meliloti Flavohemoglobinefficiently Improved Cell Growth and Fatty Acid Biosynthesis in Oleaginous Fungus Mucor Circinelloides
Authors: Zhang Huaiyuan , Kang Xinxin , Wang Ruixue , Xin Feifei , Chang Yufei , Zhang Yingtong , Song Yuanda
Published: December 2021

Oxygen availability is a limiting factor for lipid biosynthesis in eukaryotic microorganisms. Two bacterial hemoglobins from Vitreoscilla sp. (VHb) and Shinorhizobium meliloti (SHb), which could deliver the oxygen to the respiratory chain to produce more ATP, were introduced into Mucor circinelloides to alleviate oxygen limitation, thereby improving cell growth and fatty acid production. VHb and SHb genes were integrated into the M. circinelloides MU402 genome through homologous recombination, and their protein expression was verified by carbon monoxide difference spectrum (CO-difference spectrum)analysis. SHb-expressing strain showed higher biomass than VHb-expressing strain. The biomass of the SHb-expressing strain was increased by about 50% and the total fatty acid (TFA) content was as high as 15.7% of the dry cell weight which was about 40% higher than that of the control strain in flask conditions. In the fermenter, the maximum biomass and TFA content was obtained in SHb-expressing strains, with the biomass being 12.1 g/L and the TFA being 21.1% of the dry cell weight. VHb and SHb expression also affected the fatty acid composition with the proportion of polyunsaturated fatty acids being increased. Over-expression of bacterial hemoglobins, especially SHb increased cell growth and TFA content in M. circinelloides at low and high aeration, suggesting that SHb is better than VHb in improving the fatty acid production in oleaginous microorganisms.
Everybody Nose: Molecular and Clinical Characteristics of Nasal Colonization During Active Methicillin-Resistant Staphylococcus Aureus Bloodstream Infection
Authors: Schwarz Erika Reategui , de Guchte Adriana van , Dupper Amy C. , Caban Ana Berbel , Nadkarni Devika , Fox Lindsey , Mills Alexandra , Obla Ajay , Chacko Kieran I. , Oussenko Irina , Samaroo Flora , Polanco Jose , Silvera Richard , Smith Melissa , Patel Gopi , Gitman Melissa , Chung Marilyn , Sullivan Mitchell J. , Bakel Harm van , Altman Deena R.
Published: December 2021

Background. Healthcare-associated infections pose a potentially fatal threat to patients worldwide and Staphylococcus aureus is one of the most common causes of healthcare-associated infections. S. aureus is a common commensal pathogen and a frequent cause of bacteremia, with studies demonstrating that nasal and blood isolates from single patients match more than 80% of the time. Here we report on a contemporary collection of colonizing isolates from those with methicillin-resistant S. aureus (MRSA) bloodstream infections to evaluate the diversity within hosts, and detail the clinical features associated with concomitant nasal colonization.Methods. Swabs of the bilateral anterior nares were obtained from patients diagnosed with MRSA bacteremia. A single colony culture from the blood and an average of 6 colonies from the nares were evaluated for MRSA growth. For the nares cultures, we typed multiple isolates for staphylococcal protein A (spa) and derived the clonal complexes. Demographic and clinical data were obtained retrospectively from the electronic medical record system and analysed using univariate and multivariable regression models.Results. Over an 11-month period, 68 patients were diagnosed with MRSA bloodstream infection, 53 were swabbed, and 37 (70%) were colonized with MRSA in the anterior nares. We performed molecular typing on 210 nasal colonies. Spa types and clonal complexes found in the blood were also detected in the nares in 95% of the cases. We also found that 11% of patients carried more than one clone of MRSA in the nares. Male sex and history of prior hospitalization within the past 90 days increased odds for MRSA colonization. Conclusion. The molecular epidemiological landscape of colonization in the setting of invasive disease is diverse and defining the interplay between colonization and invasive disease is critical to combating invasive MRSA disease.
Eye Movement Abnormalities in Amyotrophic Lateral Sclerosis
Authors: Guo Xintong , Liu Xiaoxuan , Ye Shan , Liu Xiangyi , Yang Xu , Fan Dongsheng
Published: December 2021

Background and Purpose
It is generally believed that eye movements are completely spared in amyotrophic lateral sclerosis (ALS). Although a series of eye movement abnormalities has been recognized in recent years, the findings are highly controversial, and the corresponding pattern has not yet been established. Furthermore, bulbar disabilities should be considered in relation to eye movement abnormalities. The present study aimed to determine whether eye movement abnormalities are present in ALS and, if so, to investigate their characteristics and their association with bulbar disability in ALS patients.
Methods
Patients with clinically definite, probable or laboratory-supported probable ALS (n=60) and a control group composed of their caregivers (n=30) underwent clinical assessments and standardized evaluations of the oculomotor system using videonystagmography. The gaze test, reflexive saccade test and smooth pursuit test were administered to all subjects.
Results
Eye movement abnormalities such as square-wave jerks, abnormal cogwheeling during smooth pursuit, and saccade hypometria were observed in ALS patients. Square-wave jerks (p<0.001) and abnormal cogwheeling during smooth pursuit (p=0.001) were more frequently observed in ALS patients than in the control subjects. In subgroup analyses, square-wave jerks (p=0.004) and abnormal cogwheeling during smooth pursuit (p=0.031) were found to be more common in ALS patients with bulbar involvement (n=44) than in those without bulbar involvement (n=16). There were no significant differences in the investigated eye movement parameters between bulbar-onset (n=12) and spinal-onset patients (n=48).
Conclusion
ALS patients showed a range of eye movement abnormalities, affecting mainly the ocular fixation and smooth pursuit systems. These abnormalities were observed more common in the ALS patients with bulbar involvement. Our pioneering study indicates that the region of involvement could better indicate the pathophysiological essence of the abnormalities than the type of onset pattern in ALS. Eye movement abnormalities may be potential clinical markers for objectively evaluating upper brainstem or supratentorial cerebral lesion neurodegeneration in ALS.
Experiences and Factors Affecting Using WeChat among Urban Empty-Nesters: A Qualitative Descriptive Study
Authors: Yang Yuting , Yao Miao , Yang Yongwei , Lin Ting
Published: December 2021

Background

In an era where population aging and social information are intertwined, the elderly need to learn to use electronic products, but due to aging and other reasons, the process of learning to use it is not easier than that of young people. The elderly, especially the empty-nesters whose children are not around, need to adapt to using electronic products in their daily lives.
Objective

To explore the experiences of using WeChat for the urban empty-nesters.
Methods

A qualitative descriptive design was used in this study. A total of 14 registered empty-nesters who had used WeChat in Fuzhou communities were recruited via convenience and purposive sampling methods. Data were collected through individual, semi-structured, and face-to-face interviews and were analyzed according to the content analysis approach.
Results

Data analysis led to the identification of four categories and ten sub-categories including the following: (1) uncertainty about WeChat dependence (dependence or no dependence on WeChat), (2) positive experience (providing life convenience, improving spiritual life, and consciously advancing with the times), (3) negative experience (disgusting false information, disgusting negative reports), and (4) influencing using WeChat factors (Physiology, education, social support). The identification of these experiences and factors could help community workers to develop strategies to enhance older adults, especially empty-nesters’ utilization rate of electronic products such as WeChat and eventually adapt to the information society.
Conclusions

Informatization is unstoppable. Nowadays, the elderly must use electronic products, but the situations of the elderly using electronic products such as WeChat are different, and influencing factors are also different. Taking positive experiences of using WeChat as a reference promotes the elderly to participate in the information age. And taking negative experiences as a reference provides an early warning for other people using WeChat.
Identification and Validation of Key Genes in Giant Congenital Melanocytic Nevi by RNA Sequencing Analysis
Authors: Cheng Xialin , Dai Tao , Bao Wu , Chen Lingxi , Zhang Zexin , Jia Chiyu
Published: December 2021

Background
Giant congenital melanocytic nevi (GCMNs) are melanotic lesion present at birth, which often cause severe psychological and financial burden to patients and their families.However, the pathogenes is still unclear.
Objective
We aim to identify key genes and biological processes that related to the development of GCMN.
Methods
We sequenced ten pairs of GCMN tissues and adjacent normal tissues by high-throughput RNA-seq, then used GO and KEGG analysis to find inportment pathways, and used MCODE,Cluego and Cytohubba plugin of Cytoscape software to identify hub genes.
Results
A total of 1163 differentially expressed genes were identified. 29 BPs, 18 CCs, and 17 MFs were significantly enriched in GO analysis and no pathway was significantly enriched in KEGG analysis. PPI Visual Network consisted of 779 nodes and 2359 edges,which was be divided into 25 functional modules by MCODE. We discovered most of the hub genes were located in module 5,and the top 3 hub genes (PTGS2,EGF,SOX10) in module 5 were involved in GO and KEGG enrichment pathways --“Arachidonic acid metabolism”,”glycosaminoglycan biosynthetic process”,”developmental pigmentation” respectively.
Conclusion
PTGS2, EGF and SOX10 are thought to be the three most important hub genes and may play essential roles in the development of GCMN.
Correlating MRI-Based Brain Volumetry and Cognitive Assessment in Down Syndrome Patients
Authors: Hamadelseed Osama , Skutella Thomas
Published: December 2021

INTRODUCTION: Down syndrome (DS) is the most common genetic cause of intellectual disability. Here, we use magnetic resonance imaging (MRI) on children and adults with DS to characterize changes in the volume of specific brain structures involved in memory and language and their relationship to features of cognitive-behavioral phenotypes.METHODS: Thirteen children and adults with the DS phenotype and 12 age- and gender-matched healthy controls were analyzed by MRI and underwent a psychological evaluation for language and cognitive abilities.RESULTS: The neuropsychological profile of DS patients showed deficits in different cognition and language domains in correlation with reduced volumes of specific regional and subregional brain structures.CONCLUSIONS: The memory functions and language skills affected in our DS patients correlate significantly with the reduced volume of specific brain regions, allowing us to understand DS's cognitive-behavioral phenotype. Our results provide an essential basis for early intervention and the design of rehabilitation management protocols.
FSH Promotes Rat Follicle Development Through Inhibition of the Hippo Signalling Pathway
Authors: Chen Tairen , Wu Mengjing , Dong Yuting , Kong Bin , Cai Yufang , Hei Changchun , Wu Kai , Zhao Chengjun , Chang Qing
Published: December 2021

Purpose: Whether FSH promotes follicle growth by inhibiting the Hippo signalling pathway.METHODS: Ovaries were cultured in vitro into a control group (no intervention), an FSH group (0.3 IU/mL FSH), and a VP group (10 µg/mL vetiporfin). HE staining and follicle counts were performed at each stage after 3 hours of in vitro culture. Immunohistochemistry was performed to study the expression levels of LATS2, YAP, PLATS2, and PYAP, and their expression levels in each group were also analysed by Western blot.The number of secondary follicles was significantly increased in the FSH group, the arrangement of granulosa cells was neater, the nuclear fixation was reduced, and the number of atretic follicles was decreased in the VP group. The number of secondary follicles was significantly increased, the number of atretic follicles was reduced, and granulosa cell nuclear consolidation was reduced in the VP+FSH group. Immunohistochemistry showed that LATS2 and YAP expression levels were significantly increased and PLATS2 and PYAP expression levels were relatively decreased in the FSH group, PYAP and PLATS2 expression levels were significantly increased and YAP expression was significantly decreased in the VP group, and YAP and LATS2 expression levels were significantly increased and PYAP and PLATS2 expression levels were significantly decreased in the VP+FSH group. By Western blot, LATS2 and YAP were elevated and PYAP and PLAT2 were decreased in the FSH group, LATS2 and YAP were decreased and PYAP and PLATS were significantly elevated in the VP group, and LATS2 and YAP were elevated and PYAP and PLATS2 were decreased in the VP+FSH group.CONCLUSION: FSH promotes follicle development by inhibiting the Hippo signalling pathway.
ADP Based Fault-Tolerant Tracking Control for Underactuated AUV with Actuators Faults via Neural Network Observer
Authors: Che Gaofeng , Yu Zhen
Published: December 2021

In this work, the fault-tolerant tacking control issue of underactuated autonomous underwater vehicle (AUV) with actuators faults is investigated. Firstly, an output-feedback error tacking system is constructed based on the theoretical model of underactuated AUV with actuators faults. Then, an adaptive dynamic programming (ADP) based fault-tolerant control controller is developed. In our proposed control scheme, a neural-network observer is designed to approximate the system states with actuators faults. A novel ADP scheme is constructed with critic neural network and action neural network in order to reduce the jitter in the control input and improve the tracking accuracy. Based on Lyapunov approach, the stability of the error tracking system is guaranteed by the proposed controller. At last, the simulation results show that the underactuated AUV achieves better tracking performance.
Pharmaceutical Intervention for Adverse Events Improves Quality of Life in Patients With Cancer Undergoing Outpatient Chemotherapy
Authors: Fujii Hironori , Ueda Yukino , Hirose Chiemi , Ohata Koichi , Sekiya Kumiko , Kitahora Mika , Sadaka Shiori , Yamamoto Senri , Watanabe Daichi , Kato-Hayashi Hiroko , Iihara Hirotoshi , Kobayashi Ryo , Kaburaki Miho , Matsuhashi Nobuhisa , Takahashi Takao , Makiyama Akitaka , Yoshida Kazuhiro , Hayashi Hideki , Suzuki Akio
Published: December 2021

PurposeThe effect of pharmaceutical intervention to treat adverse events on quality of life (QOL) in outpatients receiving cancer chemotherapy is unclear. We investigated whether pharmaceutical intervention provided by pharmacists in collaboration with physicians improves QOL with outpatient cancer chemotherapy. MethodsWe conducted a single-center retrospective descriptive study of pharmaceutical intervention for patients receiving outpatient cancer chemotherapy at Gifu University Hospital between September 2017 and July 2020. We assessed patient QOL using the Japanese version of the EuroQol 5 Dimension5 Level (EQ-5D-5L). Adverse events were graded using the Common Terminology Criteria for Adverse Events (CTCAE) version 4.0. We compared the EQ-5D-5L utility value and incidence of grade 2 or higher adverse events before and after pharmaceutical intervention. ResultsOur analysis included 151 patients who underwent 210 chemotherapy cycles. Pharmaceutical intervention significantly improved patients’ EQ-5D-5L utility values from 0.8197 to 0.8603 (P < 0.01). EQ-5D-5L utility values were significantly improved after pharmaceutical intervention for nausea and vomiting (pre-intervention 0.8145, post-intervention 0.8603, P = 0.016), peripheral neuropathy (pre-intervention 0.7798, post-intervention 0.7988, P = 0.032) and pain (pre-intervention 0.7625, post-intervention 0.8197, P = 0.035). Although not statistically significant, the incidence of grade 2 or higher adverse events, including nausea and vomiting, dermopathy, pain, oral mucositis, diarrhea and dysgeusia, tended to be lower post-intervention than pre-intervention. ConclusionsPharmaceutical intervention by pharmacists in collaboration with physicians may improve QOL in patients undergoing outpatient cancer chemotherapy.
Earnings Management and New Listings: Evidence from Vietnam
Authors: Anh Huu Nguyen  , Chi Thi Duong
Published: December 2021

Earnings management around corporate events has been widely discussed in literature review which has shown mixed results. Furthermore, prior studies have extensively focused on earnings management around initial public offerings (IPOs) and seasoned equity offerings (SEOs), while less attention has been given to the listing event. Another motivation comes from the context of the undeveloped market. While earnings management has been widely discussed in developed countries, it is still limited in emerging countries in general and in Vietnam in particular, due to the lack of research on this phenomenon and the unique institutional feature and pre-listing profit requirement in Vietnam’s stock market. This research is conducted to investigate the earnings management behaviour around listing event in Vietnam. The sample of this study consists of financial data from 189 newly listed companies on the Ho Chi Minh City Stock Exchange (HOSE) for the period of 2009–2017. Four cross-sectional models were used to estimate earnings management, including two total accruals-based models and two current accruals-based models. This research makes important contributions to the body of literature on Vietnam’s stock market. First, this study provides empirical evidence suggesting a greater positive earnings management practice of newly listed firms in current accrual models than those in total accrual models. Second, the results from both parametric and non-parametric test statistics show that HOSE-listed firms present higher levels of earnings management in the year prior to the listing than those in post-listing year and two subsequent years after listing. Finally, new listing requirements in 2012 require the company’s return on equity (ROE) in the most recent year to be at least 5%. However, the paper finds no evidence to suggest that relative to all newly listed firms after the new profit requirement exhibit greater positive earnings management than that of firms listed before the change in pre-listing year.
SYMPTOMATIC MECKELS DIVERTICULUM IN THE NEWBORN: REVIEW OF THE LITERATURE
Authors:   Pediatric Surgery. Faculty of Medicine and Pharmacy. University Ibn Zohr Agadir., Cherrabi Hind
Published: December 2021

Meckels diverticulum accounts for 2 to 3% of gastrointestinal tract malformations in children. It is a distal remnant of the incompletely obliterated omphalo mesenteric duct that occurs at 4 weeks gestation, and is located approximately 40 to 60 cm from the last ileal loop. In the majority of cases, its presentation is asymptomatic and discovery is incidental. The symptomatic form represents 4% and is rare in children, including bleeding, occlusion, inflammation and intermittent umbilical oozing. The symptomatic form is exceptional in newborns. This work is a descriptive study of the literature regarding reported cases of newborns diagnosed with symptomatic Meckels diverticulum either as a picture of intestinal obstruction or by spontaneous perforation of the DM The objective of our study is to describe the cases of newborns operated in emergency for symptomatic Meckels diverticulum and to evaluate the surgical management.
MECHANICAL PROPERTIES OF RNA NANOWIRES
Authors:   206, Shrinidhi Flat, Amrakunj Society, Kankaria, Ahmedabad - 380008, Gujarat., Shah Het , McEwan Andrews ,   Adani Vidya Mandir, Ahmedabad - 380051, Gujarat.
Published: December 2021

RNA is a polymeric genetic bio-molecule found in all human beings. It is the main genetic material in many viruses. In this paper we test the mechanical properties of RNA NWs. We will find Youngs Modulus of RNA Nanowires (NWs) as a function of diameter with taking equilibrium strain, Poissons ratio and surface stress in consideration. As previously no study has been published regarding Youngs Modulus of RNA we take a theoretical approach towards it. We will predict the behavior of RNA NWs and see the resemblance to either semiconducting or metallic nature of NWs. This study extrapolates key factors in modelling RNA NWs for the creation of nanowires based aptasensors, genetics and other related applications.
ROLE OF THE TOP MANAGERS IN CO-CURRICULAR PROGRAM IMPLEMENTATION IN PRESERVICE TEACHER EDUCATION INSTITUTES
Authors:   Maharagama National College of Education, Sri Lanka., Tennekoon Shashini
Published: December 2021

This study is directly related to understanding the process of co-curricular implementation in a Preservice Teacher Training Institute in Sri Lanka, in order to get the maximum benefit of it with the view of making teacher training more effective in these institutions.
THE MODERATING ROLE OF ORGANIZATIONAL LEARNING CAPABILITIES ON THE RELATIONSHIP BETWEEN TQM PRACTICESAND INNOVATION PERFORMANCE
Authors:   Gunalan A/L Nadarajah, Universiti Utara Malaysia., Rashid Saleem Al-Jabri Ahmed , Utara Malaysia Universiti ,   Gunalan A/L Nadarajah, Universiti Utara Malaysia.
Published: December 2021

Total quality management (TQM) has gained importanceglobally, in order to gain a competitive advantage. Implementation of quality management is a problem faced by many sectors. The aim of the current study is to develop a model that can be implemented in any sector in order to improve the quality management practices as well as enhancing innovation performance in order to gain a competitive advantage. The conceptual model developed in the current study is supported by the previous studies. The current study asserts that TQM practices (top management support, customer focus, continuous improvement, employee involvement)as one set of practicesaffect the innovation performance, and this relationship is moderated by organizational learning capabilities. By researching databases such as JSTOR, Emerald, Tylor and Francis etc., the study was able to offer literature support. The keywords such as organizational learning, innovation, total quality management, organizational learning as a moderator etc were used to find the literature. The current study also provides the recommendations and limitations as well as the conclusion.
CHALLENGES OF PHYSICAL EDUCATION STUDENTS IN ONLINE LEARNING USING GOOGLE CLASSROOM DURING COVID-19 PANDEMIC
Authors:   Emilio Aguinaldo College, Manila, Philippines Graduate School., Jose S. Dela Cruz Francis
Published: December 2021

This study utilized the descriptive research design to determine the challenges of the Bachelor of Physical Education Studentsin an On-line Learning using Google Classroom during the Covid -19 Pandemic.The study used the descriptive statistics such as frequency count, percent, mean, standard deviation, sample variance, kurtosis, skewness, and confidence level to interpret and analyze the data gathered that will determine the activities carried out by the BPED Students using Google Classroom, current issues encountered by the students in an online learning, and about the alternative online platforms and the level of satisfaction of the students in an online-learning.
CLINICAL IMPLICATIONS OF ANTHROPOMETRIC STUDY OF FACIAL INDEX IN FIRST YEAR MEDICAL STUDENTS OF SKIMS MEDICAL COLLEGE
Authors:   Associate Professor Anatomy, Skims Medical College., Hassan Ashfaqul , Yasser Abdullah Mir ,   Post MDS (Orthodontics) Resident Skims Medical College., Hamid Sajad ,   Associate Professor Anatomy, Skims Medical College., Mursaleen Tazeem Bukhari Sayed ,   Medical Officer, J&K Health Services., Nabi Bilkeesa ,   Resident Anatomy, Skims Medical College.
Published: December 2021

Introduction:The structure of face is dependent on various attributes such as gender, ethnic background, race,climate , socioeconomic status and genetics. The facial index is the ratio of facial height (distance between Nasion and Gnathion) and maximum facial breadth(distance between two zygomatic prominences from Right zygonion to Left zygonion). Methods:A total of one hundred and twelve (112) First year medical students studying at Sheri Kashmir Institute of Medical Sciences Bemina Srinagar, Kashmir were chosen as the subjects for the present study. The study was carried out at Department of Anatomy, Sheri Kashmir Institute of Medical Sciences Bemina Srinagar Kashmir. Results:The conducted research provides important information concerning the total facial index (TFI), face shape, and facial phenotype in the adult population. The mean values of the morphological facial height and facial breadth in males were, respectively150mm and 155.5mm.while in females, respectively were: 142.5 mm and 170.0mm . Conclusion:Keeping in view the results obtained in this study we concluded that the dominant facial phenotype in the medical students of sheri Kashmir Institute of medical sciences is EuryproscopicandLeptoproscopic in male students and in male students.The results obtained may be harnessed as a reference for facial analysis that will be further useful in Orthodontics, anthropological research, forensics, genetic research and reconstructive surgery.
LE TRANSPORT MARITIME EN COTE DIVOIRE: QUELQUES ELEMENTS EXPLICATIFS DE VITALITE (1960-1980)
Authors:   Maitre-Assistant DepartementdHistoire Universite Felix Houphouet-Boigny de Cocody Abidjan-Cote dIvoire., Bernard Koffi Loukou
Published: December 2021

This article deals with the foundations of the development of maritime transport from 1960 to 1980. Indeed, during this period, maritime transport uses modern port infrastructures, notably the autonomous port of Abidjan and that of San-Pedro and national shipping companies for its development. Maritime transport is also developing thanks to the remarkable results of the national shipping companies and the autonomous ports of Abidjan and San-Pedro.
MULTIMODAL IMAGING OF CORNEAL NEOVESSELS: OCT ANGIOGRAPHY IN COMPARISON TO FLUORESCEIN ANGIOGRAPHY ON 10 EYES AND REVIEW OF THE LITERATURE
Authors:   Establishment: Specialty Hospital, Department B of Ophthalmology, Rabat, Morocco., Akannour Younes , Habiba Tazi ,   Establishment: Specialty Hospital, Department B of Ophthalmology, Rabat, Morocco., Serghini Louai ,   Establishment: Specialty Hospital, Department B of Ophthalmology, Rabat, Morocco., Abdallah El Hassan ,   Establishment: Specialty Hospital, Department B of Ophthalmology, Rabat, Morocco., Amina Berraho ,   Establishment: Specialty Hospital, Department B of Ophthalmology, Rabat, Morocco.
Published: December 2021

Introduction:The use of OCT angiography for the analysis of neovessels of the ocular surface is currently at the experimental stage. Through this work we evaluate the benefits of OCTA in the detection of corneal neovessels, their depth and surface, the signs suggestive of activity / quiescence in comparison to fluorescein angiography. Materials And Methods:10 patients (10 eyes) with corneal neovessels (CNV) were prospectively recruited to Ophthalmology B at the Rabat Specialty Hospital between June and September 2019. All patients received OCT A fluorescein angiography (AF) at two-week intervals. Results:The results of the OCT A matched the AF data by showing immature neovessel (NV) characteristics for the early-diffusing NVs, allowing the study of the structure : trunk, numbers of segments, and fractal divisions, the existence of apical loop. As well as the detection of the flow level, exudative phenomena and associated lesions in high resolution OCT B. Discussion:Few studies have evaluated the OCTA in the evaluation of NVC, the published articles analyze the feasibility and reproducibility of this technique. Our initial analyzes suggest that scans provide better penetration and resolution of NVCs, but this requires direct comparative studies between OCTA systems used to scan the same eyes. The learning curve seemed fast for this technique. Conclusion :The evaluation of antiangiogenic treatments and the risk of graft rejection, it should be noted when interpreting OCTA scans of the anterior segment that artifacts may appear in dense scars areas in addition to motion artifacts.Future software enhancements and optimization for anterior segment acquisition may reduce these artifacts even more and improve the resolution of the image.
ALIGNING ENTREPRENEURIAL ORIENTATION AND OPEN INNOVATION FOR BETTER EXPLANATION OF INDUSTRIAL TUNISIAN SMES PERFORMANCE
Authors:   Lab. ISEFE, Management Department, Faculty of Economics and Management of Tunis FSEGT, el Manar II, Tunisia., Ben Salem Ben Gaied Chiraz , Zouaoui Mahmoud ,   Lab. ISEFE, Management Department, Faculty of Economics and Management of Tunis FSEGT, el Manar II, Tunisia.
Published: December 2021

The main objective of this research is to examine the effect of the alignment as gestalt of Open Innovation and Entrepreneurial Orientation on the Industrial Tunisian SMEs performance. To achieve this aim, we carry out a quantitative survey with a questionnaire distributed to 110 Industrial Tunisian SMEs and mobilize the perspective of alignment as gestalt of the configurational approach. Our results reveal an empirical taxonomy which distinguishes four Tunisian SMEs configurations named, The Conservative Enclosed, The Committed Exceptional, The Vigilant Receptive and the Innovative Involved. Our findings show that The Committed Exceptional and Innovative Involved configurations register the same high level of performance. However, the Conservative Enclosed is the least performed unlike the Vigilant Receptive configuration which is characterized by an average level of performance. Overall, theoretical and empirical contributions are heralded to advance the relevance of Open Innovation approach to the entrepreneurship theory.
IOT BASED MOLECULAR MARKERS FOR DISEASE RESISTANCE STUDIES IN RICE - STRATEGY AND CHALLENGES
Authors:   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh, India., Sai Kumar Thota Yeswanth , Uriti Harshitha ,   Department of Computer Science and Engineering, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, India., Lakshmi Mandadapu Sree ,   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Vaddeswaram, Andhra Pradesh, India., Mohammed Junaid Shaik ,   Department of Electronics and Communication Engineering, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, India., Tharun Kumar Reddy Byreddy ,   Department of Electronics and Communication Engineering, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, India., Sandeep Geddada Sai ,   Department of Electronics and Communication Engineering, Koneru Lakshmaiah Education Foundation, Andhra Pradesh, India., Veeravilli Suryanarayana ,   Department of Humanities and Basic Sciences, Aditya Engineering College, Surampalem, Andhra Pradesh, India.
Published: December 2021

Rice production is constrained by diseases of fungal, bacterial and viral origin. The Internet of Things (IoT) â€“ network of interconnected devices - is an application for disease related uses, collection of data, processing for testing and monitoring. This review article aims about how IoT can track and allows disease resistance studies in in Oryza species. Among them Xanthomonas oryzae, Magnaporthe grisea, RYMV (Rice yellow mottle virus), and brown planthopper causes the high yield losses. Disease resistance genes are identified and they are screened by the SSR (simple sequence repeats), RAPD (Randomly Amplified Polymorphic DNA) and RFLP (restriction fragment length polymorphisms) analysis.
WEAR CHARACTERIZATION OF LM29 ALLOY WITH40 MICRON SIZED B4C REINFORCED METAL COMPOSITES
Authors:   Associate Professor, Department of Mechanical Engineering, AMC College of Engineering, Bangalore-560083., Pathalinga Prasad G. , Chittappa H.C. ,   Associate Professor, Department of Mechanical Engineering, UVCE, Bangalore-560001., Nagaral Madeva ,   Design Engineer, Aircraft Research and Design Centre, Hindustan Aeronautics Limited, Bangalore-560037.
Published: December 2021

This paper deals with the fabrication and evaluation of wear properties by introducing40 micron size B4C particulates into LM29 alloy matrix. LM29 alloy based metal matrix composites were prepared by stir casting method. 3, 6 and 9 wt. % of 40 micron sized B4C particulates were added to the base matrix. For each composite, the reinforcement particles were pre-heated to a temperature of 600 degree Celsius and then dispersed in steps of two into the vortex of molten LM29 alloy to improve wettability. The Micostructural study was done by using Scanning Electron Microscope (SEM), which revealed the uniform distribution of B4C particles in matrix alloy, EDS analysis confirmed the presence of B4C particles in the LM29 alloy matrix.A pin-on-disc wear testing machine was used to evaluate the wear loss of prepared specimens, in which a hardened EN32 steel disc was used as the counter face. The results revealed that the wear loss was increased with increase in normal load and sliding speed for all the specimens. The results also indicated that the wear loss of the LM29-B4C composites were lesser than that of the LM29 matrix. The worn surfaces and wear debris were characterized by SEM microanalysis.
THE IMPACT OF TQM PRACTICES AND ORGANIZATIONAL LEARNING CAPABILITIES ON INNOVATION PERFORMANCE IN HIGHER EDUCATION INSTITUTIONS
Authors:   Universiti Utara Malaysia., Rashid Saleem Al Jabri Ahmed , A/L Nadarajah Gunalan ,   Othman Yeop Abdullah Graduate School of Business Universiti Utara Malaysia.
Published: December 2021

Nowadays, innovation performance has become the source of organizations to gain competitive advantage and sustain their position in the market. The higher education institutions are facing challenges in implementing quality management to improve innovation performance and gain a competitive advantage. The primary aim of this paper is to develop a conceptual model for higher educationto improve innovation performance by improving their quality management practices as well as improving their organizational learning capabilities. The model developed in this study is supported by the previous literature. This paper emphasizes thattotal quality management (TQM) practices (top management support, customer (student) focus, continuous improvement, employee involvement) as one set of practice and organizational learning capabilities affect the innovation performance. The support of literature was added by consulting the databases such as JSTOR, ScienceDirect, Emerald,Tylor and Francis. The keywords used to find the related literature are Innovation in the education sector, Innovation performance, TQM and innovation, Organizational learning and innovation etc. The recommendations and conclusion of the paper are presented at the end.
DEVELOPMENT OF COMPRESSIVE STRENGTH AND ULTRASONIC PULSE VELOCITY RELATIONSHIP OF MICROBIAL CONCRETE USING BACILLUS SUBTILIS BACTERIA
Authors:   Lecturer, Department of Civil Engineering, Chittagong University of Engineering & Technology, Bangladesh., Saiful Islam Mohammad , Saiful Islam Md. ,   Professor, Department of Civil Engineering, Chittagong University of Engineering & Technology, Bangladesh.
Published: December 2021

Concrete,a multiscale composite in its natural state, is an absolutely essential element of infrastructure throughout the world. Concrete is able to carry high compressive load but very weak in case of tensile forces, for which steel bars are embedded in the concrete.Again, cracks in concrete are unavoidable. Corrosive elements can go into cracks once theyve formed and consequently deterioration of the structural concrete starts with the corrosion of embedded steel. This leads to the strength reductionand durability curtailment of concrete. So, crack minimization in reinforced concrete is a must for both strength and durability aspect as well as for economic reasons as crack repair is a costly process. The goal of this study is to compare the performance of traditional and bacterial concrete and to find a link between compressive strength and bacterial culture concentration, as well as to determine the optimal bacterial concentration in concrete. 100 mm cubical sizeconcrete specimens were cast and cured for different ages in plain water to study the strength aspect and ultrasonic pulse velocity (UPV) analysis of concrete using Bacillus subtilis bacteria.With different bacterial concentrations of 2.12 x 108 cells/ml, 2.12 x 107 cells/ml, 3.25 x 108 cells/ml, 3.25 x 107 cells/ml, 6.39 x 108 cells/ml, 6.39 x 107 cells/ml, 7.91 x 108 cells/ml and 7.91 x 107 cells/mlconcrete specimens have been studied. From the investigation it is found that concrete specimens containing bacterial species shows better performance than conventional concrete due to calcite precipitation. Among them, concrete specimens of bacterial concentration 6.39 x 108 cells/ml of bacterial water shows better result against strength deterioration and UPV analysis.
EFFECT OF MEDITATION ON MENTAL HEALTH- A SYSTEMATIC LITERATURE REVIEW
Authors:   Assistant Professor, Department of Psychology, School of Allied Healthcare and Sciences, Jain Deemed-to-be- University, Bangalore, India., Roy Choudhury Nidhi , Batra Jahanvi ,   M.Sc. Clinical Psychology, Department of Psychology, School of Allied Healthcare and Sciences, Jain Deemed-to-be-University, Bangalore, India.
Published: December 2021

Meditation is increasingly being practiced as a therapeutic technique. It is a practice where an individual uses mindfulness, focusing on a particular object or thing, feeling or thought to train themselves and increase the self-awareness to achieve calm and a clear mind to attain a stable state. Effects of meditation have generally been positiveits estimated that 200â€“500 million people meditate worldwide. Over 14% of Americans have meditated at least once. Meditation also increased lately and the number of people practising has increased rapidly. There have been several articles, researches and books which have been released. Meditation will help the individual change attitude towards life, and provide peace of mind and happiness. It helps to achieve a better understanding of themselves as well as others. This review focuses on studying and understanding the negative and positive effects of meditation on mental health and how meditation helps in reducing anxiety. It focuses on pros and cons of meditation as well. Meditation depends on individuals and each one of them has a different experience. People have experienced both pleasant and unpleasant experiences.