bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatial Profiling of CXCL10 in Breast Cancer: TAMs' Mediation of Immune Response
Authors: de Souza Natália Cordeiro de Albuquerque d’Alva , Simizo Adriana , Duarte Ana Kelly da Silva Fernandes , Gomes Emisael Stênio Batista , Silva Victor Menezes , Moura Edilson Leite , Baggio Jussara Almeida Oliveira , Rodrigues Amanda Karine Barros Ferreira , Farias Karol Fireman , Figueiredo Elaine Virginia Martins Souza , Marques Carolinne Sales , Fraga Carlos Alberto Carvalho
Published: February 2024

Background
Tumor-Associated Macrophages play a significant role in the tumor microenvironment of breast cancer, influencing its growth and progression. Their presence is associated with key processes such as angiogenesis and immunomodulation, impacting the immune system response and tumor aggressiveness.
Methods
This study employed various methods to analyze scRNA-seq and spatial transcriptome data. The scRNA-seq data underwent thorough processing and analysis, with a specific focus on breast cancer subtypes. The CellChat R package was employed to analyze and visualize cell-cell communication networks within the scRNA-seq data. hdWGCNA, conducted in R, involved multiple steps such as data preprocessing, gene network construction, module identification, module preservation analysis, and functional enrichment analysis. To analyze the pseudotime dynamics of endothelial cells, Monocle3 was utilized. The spatial data for normal skin and leprosy were obtained and analyzed using the SPATA2 and semla R packages, facilitating the integration of spatial and single-cell data.
Results
The study utilized scRNA-seq and spatial transcriptome data to comprehensively analyze 40 samples of breast cancer, including ER+, HER2+, and TNBC subtypes, alongside normal mammary tissue. Distinct cellular clusters were identified, and myeloid cells were characterized into four subtypes. Comparative analyses across breast cancer subtypes highlighted variations in the expression of the CXCL10 gene, and hdWGCNA provided insights into molecular landscapes. Trajectory inference analysis revealed pseudotime dynamics in myeloid cells, with specific gene expression changes. Spatial transcriptome profiling in TNBC and HER2 + breast cancer showed unique cellular clusters and gene expression patterns within the tumor microenvironment. The integration of spatial and single-cell data emphasized the distribution of cell types and spatial enrichment of gene expression signatures.
Conclusions
TAMs emerge as key players engaging in multifaceted interactions with neighboring cell types within the intricate context of breast cancer. These identified genes, particularly CXCL10, assume central roles in regulating various facets of myeloid cell physiology and modulating immune responses. The observed increase in CXCL10 expression in TNBC macrophages suggests a potential association with T lymphocyte activity and myeloid cell chemotaxis, implicating its significance in the intricate immune response dynamics within the TNBC microenvironment.
The role of LOC339529 in the prognosis of brain glioma patients
Authors: Ma Lincen , Yang Cao , Ge Chang , Xu Jingxuan , Yang Yan , Zhang Xu , Sheng Qiang , Shao Yunxiang , Deng Guoqi , Liu Siyuan
Published: February 2024

Background Glioma is the most frequent primary intracranial malignant tumor. Using the TCGA database, we found that the high expression of LOC339529 was associated with a good prognosis of patients. We wanted to explore the role of LOC339529 in the prognosis of brain glioma patients in the real world. Methods The clinical data, imaging data and pathological wax pieces of brain glioma patients diagnosed and treated by the Department of Neurosurgery, the Second Affiliated Hospital of Xinjiang Medical University from January 2019 to December 2021 were collected. The diameter lines of the largest glioma layer were measured, LOC339529 expression level, and grouping statistical analysis was performed according to LOC339529 expression level, whether there is relapse or death. Results 14 patients, survival time 4–44 months, median survival time 22 months (IQR, 14.5–36.5). The low expression group of LOC339529 is dominated by patients under or equal to 45 years old, while the high expression group is dominated by patients over 45 years old, and there is no significant statistical difference in prognosis between the two groups (P = 0.343). Conclusions Limited clinical data cannot currently verity that high expression of LOC339529 is associated with good prognosis in patients.
WITHDRAWN: On Practical uniform of perturbed triangular system of two differential equations named by integral input stat stable system
Authors: Moter Amany M. , Ellouze Ines
Published: February 2024

In this paper, we prove that the practical uniform integral input to stat stable of nonlinear system is perturbed triangular systems under sufficient conditions depending on a parameter and we demonstrate by cascade interconnection.
Effect of Chloramine T and Chlorhexidine in reducing gingivitis in patients admitted to a reference hospital for cardiopulmonary care: a randomized, controlled clinical trial
Authors: Matos Ylana Rosa , Leal Isabelly de Carvalho , Silva Ana Beatriz Alves da , de Oliveira Naiara Ferreira , Pinheiro Islla Ribeiro , Veras Pedryna Maria Oliveira , Silva Paulo Goberlânio de Barros , Sampaio Eliane Ferreira , Filho Edson Luiz Cetira
Published: February 2024

Objective
The aim of this study is to evaluate the effect of Chloramine T in reducing gingivitis in hospitalized patients, in addition to providing an alternative to the use of Chlorhexidine.
Material and methods
A randomized, triple-blind, placebo controlled clinical trial was performed with 45 volunteers presenting with gingivitis. Patients were randomly allocated into one of three groups: (G1): Chloramine T 0.2%; (G2): Chlorhexidine 0.12% and (G3): distilled water.
Results
After five days, the control group (G3) remained without relevant differences in relation to the first pre-treatment assessment, while the groups tested with chlorhexidine and chloramine T showed improvement in the Löe Gingival Index (LGI) (p< 0.05). After ten days, G3 maintained the results of the previous assessments, G1 repeated the five-day assessment and G2 obtained a statistically significant difference, with a better result in relation to the previous assessment (p<0.05). After fifteen days, G3 showed no differences in relation to the other assessments, G1 had a statistically significant difference, showing better performance in relation to the previous assessment and G2 continued the gradual improvement it had been showing in the LGI (p<0.05).
Conclusions
Chloramine T and Chlorhexidine present similar results in the treatment of gingivitis, when evaluated by probing by the LGI, and Chloramine T can be used effectively, without causing the adverse effects inherent to prolonged use of chlorhexidine.
Clinical relevance
Importance of oral hygiene for patients admitted to hospitals with the use of adjuvant substances that do not present adverse effects such as chlorhexidine, which is considered the gold standard, seeking to provide better clinical protocols.
Study on the Morphological Characteristics and Formation Mechanism of Thermally Modified Bamboo Milling Dust
Authors: Cui Yunqi , Qiu Hongru , Wang Baojin , Ding Tao , Gong Meng , Zhu Nanfeng
Published: February 2024

The hazards of dust are receiving increasing attention with the application of bamboo industrialization. This study focuses on the morphological characteristics and formation mechanisms of milling dust from raw bamboo (RB), dried bamboo (DB), and thermally modified bamboo (TMB) treated at temperatures of 160°C, 190°C, and 220°C. The bamboo milling particle size distribution, area-equivalent diameter, minimum Feret diameter, aspect ratio, roundness, and convexity were investigated by using sieving and flatbed scanning image methods to analyze their morphological characteristics. Furthermore, Fourier-transform infrared spectroscopy (FTIR) and X-ray diffraction analysis (XRD) were employed to investigate the chemical composition changes with the dust. The formation mechanism of bamboo milling dust was explained by the finite element simulation. The research shows that bamboo thermal modification has a significant impact on the particle size distribution, and generates the excessive inhalation of dust. Thermal treatment temperature influences dust morphology and distribution and adds similar features to dust. The thermal treatment has a notable influence on the convexity of milling dust and reduces the surface dispersion of dust, and the stability of dust morphology has been improved. Moreover, thermal modification caused the degradation of hemicellulose and increased crystallinity which affected bamboo's transverse mechanical properties. The bamboo milling deformation and chip formation are investigated through finite element simulation, and three kinds of chip morphologies larger than 200 μm and four kinds smaller than 200 μm were analyzed. The study contributes to understanding the characteristics of thermally modified bamboo milling dust and provides basic data for cleaner production and health protection.
Sprint Biomechanics Assessment with Low-cost Systems: a Reliability Study
Authors: Mildenberger Clarisa , Aragona Alfio , Guissani Carlos , Panci Nahuel , Delgado Gabriel
Published: February 2024

The individual determination of force-velocity and power-velocity profiles during sprint is of great interest to coaches and sports physiotherapists. As a very short action, sprint evaluation requires a sufficiently accurate and reliable system. The aim of this study was to analyze the reliability of the free software Kinovea®, compared to the MySprint App (Apple Inc, USA). Thirty-one soccer players were evaluated and a comparative study was carried out, where 62 sprints of 30-meters were analyzed by two rates: experienced and non-experienced. Vertical poles were placed at 2.5, 5, 7.5, 10, 15, 20, 25 and 30 meters. All the sprints were recorded in slow motion and HD image quality. Comparisons of partial and total times were made, in addition to force, velocity and power outputs. No differences were shown between the two measurement methods for the different sprint times (ICC = 0.676–0.941, p < 0.001). The intra-rater reliability of total time in the experienced rater was almost perfect: ICC = 0.993 for Kinovea and 0.984 for the MySprint app; the intra-rater reliability for non-experienced one was 0.833 for Kinovea and 0.862 for the MySprint app. Comparing both methods, the ICC was 0.896. There were no significant differences between the variables force, velocity and power (p > 0.05). This study shows that Kinovea + Excel spreadsheet is a reliable method, also an accessible and low-cost option for sport professionals. However, experience using the software is required, but not for the use of the MySprint app, which is an advantage for non-experienced testers.
Preparation and Characterization of Fumed Silica Added PMMA Denture Composites
Authors: Kucukesmen Hakki Cenker , Sarac Mehmet Fahri
Published: February 2024

A study was carried out to investigate the chemical, mechanical, and structural properties of increasing amounts of fumed silica loaded onto PMMA composite. 1% wt. fumed silica material yielded the highest values of flexural strength (105.64 MPa) and hardness (20.07 microvickers). According to DMA results, fumed silica samples contained 1% wt. had the highest energy storage (3.24 GPa at 30°C) and glass transition temperature. As a result, fumed silica in PMMA composite reached its maximum saturation limit at 1%wt. A more brittle behavior was observed in samples containing 2% fumed silica, which accumulated on the surface. The molecular bonds at the resin-fumed silica interface weaken due to the agglomeration of fumed silica. Consequently, flexural strength and hardness are reduced, as well as glass transition temperature and storage modulus. PMMA composites can be reinforced with fumed silica by acting as a reinforcing agent.
Application of a three-dimensional printed inferior mesenteric artery model in laparoscopic radical resection with preservation of left colic artery for rectal cancer
Authors: Zhao Zongxian , Hu Zongju , Liu Qinlingfei , Su Xinyu , Zhu Shu
Published: February 2024

Background
Preservation of the left colic artery (LCA) reduces the incidence of anastomotic leakage (AL) in radical resection of rectal cancer (RC). However, anatomical variations in the branches of the inferior mesenteric artery (IMA) and LCA present significant surgical challenges. Here, we construct a 3D-printed IMA model to precisely determine the location and course of the LCA before surgery, and investigate the beneficial impact of this model on surgery performance.
Methods
We retrospectively reviewed patients with RC who received laparoscopic radical resection between January 2022 and November 2023 at Fuyang People's Hospital. Patients were divided into 3D printing group (cohort A) and control group (cohort B) and their perioperative characteristics were statistically analyzed.
Results
Cohort A comprised 44 patients, while cohort B consisted of 57 patients. Operating time (200.340 ± 44.254 vs. 237.018 ± 71.006 min, p = 0.004), intraoperative blood loss (37.500 ± 14.480 vs. 63.333 ± 25.843 ml, p = 0.001), duration of hospitalization (14.022 ± 2.398 vs. 18.263 ± 9.328 days, p = 0.004), and postoperative recovery time (8.841 ± 2.088 vs. 11.461 ± 6.602 days, p = 0.014) were significantly lower in cohort A than in cohort B. There were no significant differences in the number of lymph node dissections, presence of lymph vessel invasion, and AL between the two groups.
Conclusions
Utilization of a 3D-printed IMA model in laparoscopic radical resection of RC can assist the surgeon in understanding the LCA anatomy preoperatively, reducing intraoperative bleeding, shortening operating time, and promoting rapid postoperative recovery.
Cloning and expression of acetaldehyde dehydrogenase from archaea and its application in acrylamide elimination from fried foods
Authors: Xue Luzhou , Chen Wanli , Yu Yiqun , Ni Hao , Hao Yue , Kang Xinxin , Lu Jing , Lyu Mingsheng , Wang Shujun
Published: February 2024

High-temperature frying is a common food processing method, and fried foods are favored by consumers due to its unique flavor and good taste. However, the degradation of unsaturated fatty acids in fats and oils during high-temperature processing results in the production of toxic lipid hydroperoxides (LOPs), saturated and unsaturated aldehydes, as well as acrylamides, which have been classified as group I carcinogens by the International Agency for Research on Cancer (IARC). In this study, high-temperature acetaldehyde dehydrogenase (SufALDH) of marine thermophilic archaeon Sulfolobus tokodaii 7 cloned and expressed. The optimal temperature was 88℃ and the optimal pH was 8.0. The SufALDH enzyme was further used for the pretreatment of fried food, which led to significant reduction in the aldehyde content of the fried food. In SufALDH-treated French fries, fried chicken and fried fish, aldehyde content reduced by 60%, 52% and 33%, respectively, while 40% reduction in acrylamide was observed in the French fries treated with SufALDH. Molecular docking indicated seven key amino acid residues between SufALDH and substrate acetaldehyde, acrolein, acrylamide and isopropyl alcohol, and they will be mutated to improve the SufALDH characteristics for it further application in food industries.
Does redistribution hurt growth? An Empirical Assessment of the Redistribution-Growth Relationship in the European Union
Authors: Christl Michael , Köppl-Turyna Monika , Poli Silvia
Published: February 2024

This paper analyzes the relationship between economic growth, inequality and redistribution. In a cross-country setting for 25 EU countries over the period 2007-2019, we show that market income inequality is associated with higher growth in the short run. To estimate the impact of redistribution to low-income earners, we introduce a new measure, the so-called net benefit share (NBS). Contrary to other findings, we show that this (targeted) redistribution to low-income earners (Q1 NBS) boosts growth in the short run, driven by the consumption and private investment channels. On the other hand, untargeted redistribution to higher income earners reduces growth.
JEL Classification: H23 , O47 , D63
Nursing/Midwifery students’ perceptions of on-line education during COVID-19
Authors: Jones Rikki , Jackson Professor Debra , Rice Kylie , Fisher Associate Professor Murray , Calleja Associate Professor Pauline , Hopkins Martin , West Professor Caryn , Irwin Associate Professor Paulette , McGough Shirley , Luck Associate Professor Lauretta , Walker Felicity , Whiteing Associate Professor Nicola , Usher Professor Kim
Published: February 2024

Aim: This study aimed to gain a better understanding of nursing/midwifery students’ perspectives of the changes to the delivery of undergraduate nursing/midwifery education due to the COVID-19 pandemic, assess whether students perceived a caring pedagogy in their online learning, and investigate whether students’ intention to continue their education and enter the nursing/midwifery workforce has changed due to the pandemic and/or changes in education delivery.
Design: Mixed methods
Methods: A multi-centre cross-sectional survey of Australian nursing and midwifery students were undertaken to explore students experience quantitatively and qualitatively of learning during COIVD-19 pandemic.
Results: There are several key findings from this study that may be relevant for future delivery of undergraduate health education, students transitioning to practice, and health care workforce retention. The study found that although students were somewhat satisfied with online learning during COVID-19, students reported significant issues with knowledge/skill acquisition and barriers to the learning process. The students reported feeling less prepared for practice, and identified how clinical staff were unable to provide additional guidance and support due to increased workloads and stress. The textual responses of participants highlighted that connection/disconnection, empathy and engagement/disengagement had an impact on learning during COVID-19.
Conclusion: This finding suggests the importance of connection alongside the decreasing face to face interactions (for example increased reliance on social media, increasing use of online learning). This study highlights several key findings for consideration in nursing and midwifery education, the profession, and the broader context of healthcare. Graduates entering the workforce post COVID-19 have had to overcome significant barriers to education and clinical placement learning which will have impacted their level of clinical skills, confidence, and ability to practice as new gradate nurses/midwives.
Decarbonization of shipping: Hydrogen and fuel cells legislation in the maritime industry
Authors:   Istanbul Technical University, Maritime Faculty, Marine Engineering Department, Tuzla, Istanbul, Turkey, Inal Omer Berkehan
Published: February 2024

The maritime industry is a significant component of the transportation sector. Ships are the major element of the maritime industry, and propulsion power comes from fossil fuels, such as heavy fuel oil or marine diesel oil. These fossil fuels are used in conventional marine diesel engines and result in high levels of harmful emissions. These emissions contribute to the greenhouse effect and global warming, which is why efforts have been made to regulate and limit them within specific boundaries through various rules and regulations. However, with current technology, it is not possible to stay within these regulations. Therefore, the maritime sector has embarked on the quest for alternative power sources, and as a result, alternative fuels and fuel cells have gained importance. Hydrogen, one of these alternative fuels, is a promising solution with a carbon-free structure for the maritime industry to move toward sustainability. However, ships are considered high-risk areas, which is why specific standards need to be established for the use of hydrogen and fuel cell technology in ships. Hydrogen bunkering, onboard storage, and power system design, limits, and operational aspects must be properly elaborated. Although there are several substantial international standards and regulations for gas, liquid, and dangerous cargo, there is a lack of specific and detailed regulations for the use of fuel cells and hydrogen fuel onboard ships. This paper reviews the relevant regulations and standards while showing the regulatory gap concerning hydrogen and fuel cells by discussing the main barriers and highlights the current and future agenda of the industry toward decarbonization vision.
Water resources carrying capacity to achieve a sustainable ecosystem using support vector regression
Authors: Mortezazadeh Feizollah , Pourmohammadi Mohammad Hossein , Khoshnavaz Saeb , Nohani Ebrahim , Eslami Hossein
Published: February 2024

Agricultural water resources carrying capacity has been considered an important problem in recent decades. A comparison of the evaluation indicators of water resources indicated the variation levels of the stability. Machine Learning-Support Vector Regression (ML-SVR) was implemented to formulate the agricultural footprints. The obtained statuses of the water resources have always been characterized by agricultural deficit in the Hendijan plain, Khuzestan province, Iran. Experiments performed outperformed the classical model on both fitted values and the validation value. The results showed that the agricultural footprints from 2010 to 2020 in Iran kept steady with higher levels, while from 2014 to 2016 witnessed a significant decline compared with previous years. The predicted agricultural footprint for the recent 10 years continues to decrease in the semi-arid regions. The predicted results via support vector regression (SVR) showed that agricultural footprints from 2017 to 2020 will present a rising trend, meaning the situation of water crisis will be increasingly serious in the eastern parts of the central deserts.
Advanced Targeted Drug Delivery of Bioactive Agents Fortified with Graft Chitosan in Management of Cancer: A Review
Authors: Begum Rukaiah , Singh Sudarshan , Prajapati Bhupendra , Sumithra M , Patel Ravish J.
Published: February 2024

Cancer is characterized by the uncontrolled proliferation and spread of abnormal
cells in the body, resulting in the development of tumors or clusters of irregular
cells. The factors contributing to cancer are intricate, involving a combination of genetic,
environmental, and lifestyle elements. Risk factors for cancer include the use of nicotine,
excessive alcohol consumption, exposure to radiation or specific chemicals, and a
family history of the disease. Common treatment methods for cancer encompass
surgery, radiation therapy, chemotherapy, immunotherapy, and targeted therapy. These
treatments aim to eliminate cancer cells while minimizing harm to healthy cells. Recent
research has extensively explored the potential of bioactive compounds as agents for
combating cancer. However, effectively delivering such compounds to specific target
sites is a complex undertaking. Consequently, there has been widespread exploration of
polymer applications in the development of nanomedicine for delivering bioactive substances.
Additionally, the technique of grafting native excipients onto polymers has been
investigated to enhance their versatility in the delivery of these compounds to specific tumor
cells. This review offers a brief yet informative summary of how grafted chitosan is
employed as a delivery system for bioactive phytopharmaceuticals possessing anticancer
properties. In essence, it delves into the use of grafted chitosan in facilitating the transport
and targeted release of these natural compounds that have demonstrated potential in
combating cancer. This innovative approach has the potential to enhance the effectiveness
of anticancer treatments and minimize their adverse effects on healthy cells.
Exploring the Potential Benefits of Bovine Colostrum Supplementation in the Management of Diabetes and its Complications: A Comprehensive Review
Authors: Chawla Isha , Dhanawat Meenakshi , Sharma Manu , Gupta Sumeet
Published: February 2024

:

Diabetes is a metabolic illness marked by elevated levels of glucose in the bloodstream
due to the inadequate production or use of insulin in the body. Diabetes can result in a
range of consequences, with the most prevalent being cardiovascular disease, renal failure, vision
loss, and limb removal. Natural compounds isolated from different sources, like colostrum, are
the most important compounds for the treatment of diabetes. Colostrum is a form of lactation
produced by mammals in the first days after giving birth to their offspring, having a rich source
of constituents and showing multipharmacological properties.

:

This review was prepared on the basis of a variety of authoritative search databases, including
Google Scholar, Scopus, and PubMed. In addition, the publications and other online sources
were also included. In the literature search, the terms "colostrum," "diabetes," "uses," "management,"
"constituent," "composition," "alternative sources," "mechanism of action," "preclinical,"
"clinical," "marketed formulations," and "patents" were utilized as keywords and collected from
last two decades.

:

Colostrum has been utilized as a treatment for a wide variety of illnesses due to its active constituents.
A variety of colostrums are available in the market, like goat colostrum, porcine colostrum,
sheep colostrum, human colostrum and many more. They have the full potential of nutrients
like minerals, vitamins, lactose, essential enzymes, proteins and high concentrations of immunoproteins.
Mostly, the colostrums are used for treating diabetes and its complications. Preclinical
and clinical studies of metabolic syndrome, especially on diabetes and its complications,
were also reported at the National and International levels, which evidently prove that the use of
colostrums in the long term can be beneficial for various ailments associated with diabetes.

:

In general, the findings of this review indicate that supplementation with colostrum may hold
promise as a novel therapeutic intervention for people who have diabetes and its complications;
however, additional research is required to fully understand its mechanisms of action and determine
the best possible dosage as well as the time period of supplementation.
Dual-energy CT Portal Venography: Clinical Application Values and Future
Opportunities
Authors: Peng Yu Yang , Yan Jing , Li Yu Ru , Lu Xiao Rui , Wang Lu Yao , Jia Ping Fan , Guo Xing
Published: February 2024

Standard multidetector computed tomography (MDCT) uses a single X-ray tube to emit a mixed energy X-ray beam, which is received by a single
detector. The difference is that dual-energy CT (DECT), a new equipment in recent years, employs a single X-ray tube or two X-ray tubes to emit
two single-energy X-ray beams, which are received by a single or two detectors. The application of dual-energy technology to portal venography
has become one of the research hotspots. This paper will elaborate on the clinical application values of DECT portal venography in improving
portal vein image quality, distinguishing the nature of portal vein thrombus, reducing contrast agent dose and radiation dose, and will discuss the
possibility of its movement from research to routine practice and future development opportunities.
Qualitative Analysis and Anti-oxidant Potential of Ethanolic Extract ofManilkara zapota (L.) P. Royen Leaves
Authors: Sharma Priyanka , Deep Aakash , Kumar Harish , Chaudhary Devendar , Thakur Neha , Batra Shubham
Published: February 2024

Background:

The normal metabolic functioning of aerobic cells is related to free
radical formation. The oxygen utilized in the cell growth gives rise to a number of oxygen free
radicals. Further, these oxygen free radicals interact with lipidic molecules to produce hydroxyperoxides
and various other peroxides also, radicals like superoxide, hydroxyls, and lipoid
peroxides, which lead to cytotoxicity due to their interaction with biological systems. The uncontrolled
generation of free radicals may lead to various diseases and disorders like prostate
cancer, coronary heart disease and also ageing. The therapeutic potential of the plant M. zapota
has been demonstrated in various diseases, such as cancers (e.g., breast, prostate, cervical, and
hepatocellular cancer), diabetes mellitus, arthritis, bacterial infections, and gastrointestinal disorders
(e.g., diarrhea and ulcers) and many medical conditions. The main phytocomponents of
this plant are polyphenols, alkaloids, glycosides, flavonoids, saponins, triterpenoids, carbohydrates,
tannins, and sterols.

Objective:

The objective of this study is to investigate qualitative analysis and anti-oxidant potential
of ethanolic extract of Manilkara zapota (L.) P. Royen Leaves. In demand to minimize
the damage caused by free radicals. It is very essential to develop such antioxidants which protect
the body from the effect of free radicals and also do not cause much harm to the human
body. The main phytocomponents of the plant are polyphenols, alkaloids, glycosides, flavonoids,
saponins, triterpenoids, carbohydrates, tannins and sterols which are responsible for antioxidant
activity.

Materials and Methods:

Phytochemical screening methods, Gas chromatography–mass spectrometry
(GC-MS), Fourier transform infrared (FTIR), and Hydrogen Peroxide scavenging assay
for analysis of an ethanolic extract of plant leaves.

Results and Discussion:

Antioxidant activity was determined by a hydrogen peroxide assay.
Plant extract was examined using phytochemical screening, GC-MS analysis, and FTIR spectra.
The plant extract showed hydrogen peroxide scavenging activity (IC50 = 16.45 μg/ml)
compared to the IC50 values of standard ascorbic acid (IC50 = 9.079 μg/ml).

Conclusion:

The present study concluded the antioxidant and phytochemical assessment of the
ethanolic extract of the leaves of Manilkara zapota. The results of the present research study
demonstrated that the antioxidant activity of the plant extract was strong as compared to ascorbic
acid.
Salt Sales Prediction Using the Moving Average Method (A Case Study of Madura-Indonesia Salt)
Authors: Syakur Muhammad Ali , Negara Yudha Dwi Putra , Rachmad Aeri , Rochman Eka Mala Sari
Published: February 2024

Forecasting is a term used to forecast or predict the business that we run to see the direction in the future which uses historical data as the main reference. An appropriate strategy is needed to manage the production of salt raw materials properly, namely through sales forecasting. PT Budiono Madura Bangun Persada is a company engaged in salt processing with the brands "Anak pintar (AP)" and "Kapal Container (KC)" where the amount of production experiences uncertainty, namely an increase or decrease, this results in an uncertain amount of raw materials. This study aims to predict the exact amount of salt production in a certain period. The amount of data used is the period November 2020 - April 2021 as much as. The final result of this forecasting model is the best using predictions on day 6 for both AP salt and KC salt, with an MSE value of 290.71 for KC salt and an MSE value of 843.08 for AP salt
Implementation of FDSS (Fuzzy Decision Support System) Sugeno Model in Optimizing Bandwidth Requirement Management of Web-Based Networks
Authors: Lahiya Indah Wardati , Arifin Fatchul
Published: February 2024

To increase the efficacy of bandwidth allocation at PT. Digdaya Monokrom Group, this study describes the development of a Fuzzy Decision Support System (FDSS) utilizing the Sugeno methodology. The Waterfall development process is employed for the purposes of system planning, construction, and maintenance. The study consists of three primary stages: the creation of fuzzy sets, the development of fuzzy rules, and the process of defuzzification. The study findings demonstrate that the utilization of FDSS has effectively improved the distribution of bandwidth. The distribution has shifted from a uniform one to a more optimized allocation, focusing on the Execution, Content Creator, Administration, and Research Team departments. During a four-week monitoring period, modifications were implemented to distribute bandwidth based on the preferences and needs of various departments, while adhering to the limitations of the current broadband subscription. This has enhanced the efficient exploitation of network resources. The research findings highlight the efficacy of FDSS in prioritizing resource allocations according to specific departmental requirements, consequently improving service quality and maximizing bandwidth subscription capacity. This demonstrates the implementation of strategic management methodologies to optimize the allocation of network resources, resulting in enhanced organizational efficiency and production.
Design and Development of Industrial Practice Monitoring and Assessment Systems using Tsukamoto Fuzzy Logic
Authors: Pahtoni Tri Yuli , Arifin Fatchul
Published: February 2024

Vocational high schools are given flexibility for their students to carry out direct learning in the industry as part of the practical education activities of implementing student skills. The implementation of industrial practice requires a special way to find out and monitor each student's activities so that the achievements of the implementation of industrial practice can be carried out properly.  The implementation of industrial work practice assessment has several assessment criteria. These criteria include attendance, neatness, attitude, skills, and knowledge. The problems found in the assessment system are still done manually so that the effectiveness is minimal. This study aims to create a system that can monitor and assess the implementation of industrial practices.  The system developed will be tested as a medium for monitoring and assessing industrial practices.  This research uses Fuzzy Tsukamoto’s logic approach as a scoring logic  model and  uses the waterfall method as a development model consisting of analysis, design, coding, and testing. The results of the research conducted resulted in a system that can monitor and assess the implementation of industry practices.  The test was carried out by 24 people consisting of guidance teachers and students. Testing is done by testing aspects of functionality and aspects of usability. Based on the test results, the functionality aspect scored 100% (very feasible) and the usage aspect got a score of 84.8% (very feasible)
Investigation of Consultations Requested by Dermatology Inpatient (Preprint)
Authors: Dağdaş Ahmet Doğukan , Karaman Bilge Fettahlıoğlu , Aksungur Varol Lütfü
Published: February 2024

BACKGROUND

Whereas dedicated dermatology wards have been closed in some countries, they continue to exist in other countries. Inpatient consultations requested from dermatologists have been investigated widely. However, those requested by dermatologists have been taken into consideration only in a few studies.

OBJECTIVE

In this study, it was purposed to investigate such consultations especially in context of diagnoses, reasons, and consulting specialities.

METHODS

Admissions to a dermatology ward of a tertiary hospital were retrospectively analyzed for a period from January 2019 to August 2021.

RESULTS

We found 1712 (1259 medical and 453 surgical) consultations belonging to 548 admissions with a median length of stay of 15.1 days Whereas number of consultations per admission was not influenced by patient's sex, it was positively correlated by patient's age and length of stay. Highest numbers were observed in admissions with a diagnosis of bullous pemphigoid, leg ulcer, lupus erythematosus, pustular psoriasis, hidradenitis suppurativa, and pemphigus. Reasons of consultations were, in a descending order, management of comorbidity, evaluation for drug precaution, investigation for etiology, evaluation for systemic involvement, taking treatment advice, obtaining biopsy, and differential diagnosis.

CONCLUSIONS

Our findings that number of consultations per admission was high and the most common reason of consultations was comorbidity indicate that, practically, there are no more pure dermatological patients. Therefore, if dedicated dermatology wards will continue to exist, in order to lower number of consultations so length of stay, dermatologist should be trained in a manner so that they have more knowledge about common comorbidities.
Quality of life and self-efficacy amongst people with a stoma: A longitudinal study using ecological momentary assessment (Preprint)
Authors: Goodman William , Allsop Matthew , Downing Amy , Munro Julie , Hubbard Gill , Beeken Rebecca J
Published: February 2024

BACKGROUND

When a stoma is formed people with a stoma have to adjust to managing this on a daily basis. There are a number of factors which can impact upon their self-efficacy to self-manage and their quality of life including complications with their stoma, body image concerns, stigma, and the changes to their daily routine. Ecological momentary assessment studies in other populations have suggested that these constructs may vary over short periods of time and could be influenced by contextual factors. We, however, do not currently understand how context-specific factors such as what an individual is doing, who they are with or where they are could impact upon quality of life and self-efficacy in people with a stoma.

OBJECTIVE

This study aimed to understand whether quality of life and self-efficacy fluctuated over time and whether contextual factors (e.g., activity, location, or company) and time of day were associated with quality of life and self-efficacy over the course of a week.

METHODS

A smartphone-based ecological momentary assessment study was conducted over a 7-day period with measurements taken 3 times a day (morning, afternoon and evening). Measures included demographic and clinical characteristics of age, gender and time with a stoma, and self-reported self-efficacy and quality of life in the moment rated from 0-100 (with 100 being the best). Multilevel modelling was conducted due to the clustering of responses within individuals, with models run for both self-efficacy and quality of life.

RESULTS

Null multilevel models indicated that both self-efficacy and quality of life varied over time, with around 35% of total variance explained by within-person variability which suggests there are intra- individual fluctuations over time. Results indicated that for the self-efficacy model, when people were reporting from home, they had higher levels of self-efficacy than outside the home. This was the opposite for the quality of life model with higher reported levels of quality of life outside the home and also increasing levels of quality of life throughout the day.

CONCLUSIONS

These findings indicate that among people with a stoma, self-efficacy and quality of life do vary from moment to moment. Furthermore, contextual factors such as location and time of day are associated with self-efficacy and quality of life. There is a need to explore how future self-management interventions could enhance self-efficacy to self-manage outside of the home environment, with the potential for more dynamic and tailored interventions.
Peran Moralitas Aparatur Dan Sistem Pelaporan Pelanggaran Dalam Mencegah Kecurangan Dana Desa
Authors: Fadhila Dzikri Ardan , Achmad Tarmizi
Published: February 2024

Purpose: This study aims to empirically prove the effect of apparatus morality and whistleblowing system on the prevention of village fund fraud.
Methodology/Approach: This study is a quantitative research with primary data sources obtained from distributing questionnaires to respondents. The sampling technique used was purposive sampling technique. The sample of this study consisted of 174 village apparatuses in Pangkah District, Tegal Regency. The analysis technique used to test the hypothesis was multiple linear regression.
Findings: The results showed that apparatus morality and whistleblowing system had a positive effect on the prevention of village fund fraud. 
Practical and Theoretical Contribution/Originality: The results of this study are expected to contribute to improving the effectiveness of village fund management against the potential for fraud and also useful as a source of reference for other similar studies.
Research Limitation: The limitation of this study lies in the use of questionnaires as the only method of data collection, which may result in inaccurate answers from respondents. Further research is suggested to add interview methods to deepen the topic under study, as well as reduce potential bias.
THE ROLE OF ISLAMIC DA'WAH AND THE IMPLEMENTATION OF SHARIA ON THE EXISTENCE OF MUSLIMS IN THE MALDIVES ISLANDS PAST AND PRESENT
Authors: Meirison Meirison , Bukhari Bukhari , Saharuddin Desmadi , Muhammadi Qasem , Mistarija Mistarija
Published: February 2024

Writing this article aims to explain the development of Islamic da'wah in the Maldives Islands, which is unique and rarely found in other Muslim regions. So far, the Maldives is only known as a tourist spot. It is rarely known that all of the Maldives adhere to Islam. The British have also ruled the Maldives for 78 years, influencing the Maldives to some extent. What is the form of da'wah carried out by Abu al-Barakat, whose origins are still debated by historians? But what is clear is that he had a significant influence on the spread of Islam in the Maldives Islands, which is corroborated by classical sources such as the text attributed to Ibn Battuta and several contemporary books. We conducted a literature study on this paper, with a historical approach, by collecting data, verifying and analyzing the data thoroughly, and rewriting the results of the analysis inductively in a qualitative descriptive form. Islam spread in the Maldives peacefully without violence and continues to survive from Christian missionaries and Shiite sects who come to spread their views. Scholars say about the fiqh theory that faith in conscience will not be changed by the sins and heresies it commits.
Reconfiguring the Landscape at IRCAM
Authors: Natasha Barrett
Published: February 2024

Reconfiguring the Landscape at IRCAM was the third physical meeting of the three Reconfiguring the Landscape composers Natasha Barrett, Nadine Schütz and Andrew Knight-Hill. The group met at IRCAM in Paris from November 18 to 28 to embark on an intensive period of industrial site audio investigation, workshops, artistic creation, public panel discussions and listening sessions. The work period and public exhibitions were supported by and carried out in collaboration with IRCAM.
Urban Soundscape Enhancement (first tests for Subliminal Throwback installation).
Authors: Natasha Barrett
Published: February 2024

Urban Soundscape Enhancement (first tests for Subliminal Throwback installation).
Sustainable debris management by linear dynamic transportation model
Authors: Qasim Abdulamir Hussein
Published: February 2024

Management of large debris caused by building demolition necessitates a multi-faceted approach to deal with emerging side effects.‎ Because of emerging global challenges, such as population growth, and renovation ‎projects, a dynamic models need to be planned and controlled. One of the key drivers ‎of this management is determining the appropriate path for transporting waste and debris. Debris management by using the linear dynamic transportation model (LDT) is conducted to deal with the unexpected amount of debris and other solid waste. This sudden and unexpected large ‎amount of solid waste might be produced by natural disasters or by man-made catastrophes either ‎directly or indirectly. By computing several parameters in certain zones, a sensitivity ‎analysis of each parameter is performed to obtain an optimal model for disaster debris ‎management. Based on disaster debris volume, the model gave us an optimal explanation of ‎the debris disposal by locals. According to the estimated parameters and conditions, ‎significant findings appear by identifying the optimal dynamic transportation path of the debris ‎truck. Thus, by applying the LDT model, the results showed that the efficiency/inefficiency of road types and networks clearly affect the handling of debris.
Impact of high-k metal oxide as gate dielectric on the certain electrical properties of silicon nanowire field-effect transistors: A simulation study
Authors: Das Sanat , Chettri Bibek , Karki Prasanna , Kunwar Bhakta , Chettri Pronita , Sharma Bikash
Published: February 2024

Standard Metal-Oxide-Semiconductor Field Effect Transistors (MOSFETs) are
gaining prominence in low-power nanoscale applications. This is largely
attributed to their proximity to physical and thermal limits, rendering them
a compelling option for energy-efficient electronic devices. In this study,
we hypothesized that the high-? HfO2 in a quasi-ballistic SiNW MOSFET acts
as the gate dielectric. In this case, the data from the TCAD simulation and
the model demonstrated exceptional agreement. The proposed model for a SiNW
MOSFET with high-? HfO2 exhibits a consistently increasing drain current,
albeit with a smaller magnitude compared to a quasi-ballistic device (QBD).
Additionally, it shows reduced mobility and decreased transconductance when
considering the combined effects of scattering and temperature. As gate
voltage increases, temperatureinduced transconductance decline in SiNW
MOSFETs becomes significant. Our method is suitable for modeling scattered
SiNW MOSFETs with temperature effects, as TGF values are similar in the
subthreshold region for both Near Ballistic and Scattered SiNW MOSFET
models.
How Sex Works (and When it’s in Working)
Authors: R* Haider
Published: February 2024

Sexuality is a fundamental aspect of human life, including a range of physical, impassioned, and intellectual aspects. This abstract explores the elaborate mechanical details of how sex affects everything, removing the complexities that delimit human desire. Key elements include desire, ideas, and intercourse answers, all influenced by a myriad of organic, mental, and public factors. This item tests the key processes complicated in sexual functioning in the way that hormones, intellect, and reproductive organs interact. Intercourse dysfunction is a widespread issue that can improve the functioning of these processes. Common sexual dysfunctions, including sterility, rash ejaculation, and depressed sexuality have been discussed in depth. Furthermore, we investigate the intellectual facets of sexual troubles such that depiction anxiety, corpse figure concerns, and past blows can considerably impact an individual’s intercourse experience. The abstract still highlights the significance of communication and consent in athletic intercourse friendships, emphasizing that intercourse welfare is not determined only by tangible determinants. Key determinants for maintaining a fulfilling and effective sexual life were investigated, including open ideas, emotional relationships, and shared respect. In conclusion, this abstract offers observations of the multifaceted character of human lust, exemplifying how it works, and when it is in optimal disrepair. Understanding the miscellaneous factors that influence intercourse functioning and discussing average sexual dysfunctions, things, and couples can help navigate the complicated nature of their sexual lives, promoting more athletic and fulfilling relationships