bluuebunny/crossref_metadata_2025 huggingface dataset:
Aplicación móvil basado del Framework Flutter de evaluación en línea como estrategia metodológica para mejorar el aprendizaje de estudiantes Universitarios
Authors: Petrlik Azabache Ivan Carlo
Published: January 2024

The purpose of this article is to determine the influence of the online assessment mobile app as a methodological strategy to improve the learning of university students. This mobile app was developed through the Scrum methodology and coding through the Flutter framework with the Bloc design pattern on the front-end side and on the back-end side the Frameword Flask-Python was used, achieving the schematization of the software architecture. The problem is the deficiency in the learning of university students in mathematics subjects, of which this computer solution was used by students as a complement in the content of the subject, achieving effective feedback through online assessment tests and for teachers, it was considered as a methodological strategy to complement in the achievement of competence. The research design was quasi-experimental and the type was applied, the population was conformed by the 2 sections of the subject of mathematics through a pretest and a posttest using data collection tool to achieve reach the results and validate the respective hypotheses considering the result that there are significant differences (results of the input and output evaluation (p<005) being higher the mean of the Post Test (p = 0. 000) in learning and in its dimensions such as declarative, procedural and attitudinal after the student used the mobile application. Finally, we conclude that the use of the mobile application based on the Flutter framework improves the learning of university students.
Aplicación de técnicas de machine learning para la predicción de los precios de la acción APPLE
Authors: Evaristo Broncano Roberto
Published: January 2024

The objective of this publication is to compare the level of prediction of certain techniques such as time series and machine learning in APPLE stock price forecasting, which It has the largest capitalization volume in the technology sector. The price history is between January 1, 2019 and June 30, 2021, that it has been downloaded and it was used to measure the level of prediction having as a target the future price of the following day, on the 15th and on the 30th, also, other type of textual information were tested in order to measure their contribution to improving the prediction. The Root Mean Square Error (RMSE) and the Mean Absolute Percentage Error (MAPE) adjustment indicators were used, considering the criterion that to the extent that a technique has a lower value, it will be the best technique for each of the proposed scenarios. Regarding the results obtained in the application of the various techniques for each scenario, it was found that the Machine Learning XGBOOST technique with parameters tuned by Cross Validation and the Multiple Linear Regression model are the most useful for predicting the price of APPLE stock and textual information also improved the prediction level of APPLE stock price.
Diseño de líneas eléctricas con el software DLTCAD y la mejora en los tiempos de procesos de instalación de líneas eléctricas de antenas en zonas rurales
Authors: Meléndez Ramírez Freddy Jhonatan
Published: January 2024

This work aims to present the design of power lines with the DLTCAD software and the improvement in the process times for the installation of power lines for antennas in rural areas. Currently in rural areas of Peru the telecommunications service is limited and scarce, with 68.6% access to "Mobile Telephony" and 68.7% access to "Internet" (Source: ERESTEL "Residential Survey of Telecommunications Services", 2021, OSIPTEL), hence the importance of having antennas in rural areas, necessary to provide the telecommunications service to: schools, hospitals, police stations, municipalities, others, and to be able to begin to gradually close the digital gap in our country. DLTCAD is a Peruvian software and one of the best in the world in the calculation and design of power lines. The antennas located in rural areas require electricity for the proper functioning of their equipment, and to be able to operate and radiate the telecommunications service for the benefit of the most needy population with high rates of extreme poverty that do not have basic services such as: water , light and even more so in telecommunications, hence the importance of installing antenna power lines in rural areas, and the importance of designing these power lines with the use of an electrical design tool or software.
Marijuana Use and Breastfeeding: A Survey of Newborn Nurseries
Authors: Chang Pearl W. , Goyal Neera K. , Chung Esther K.
Published: January 2024

BACKGROUND AND OBJECTIVES

Marijuana use has increased nationally and is the most common federally illicit substance used during pregnancy. This study aimed to describe hospital practices and nursery director knowledge and attitudes regarding marijuana use and breastfeeding and assess the association between breastfeeding restrictions and provider knowledge, geographic region, and state marijuana legalization status. We hypothesized that there would be associations between geography and/or state legalization and hospital practices regarding breastfeeding with perinatal marijuana use.

METHODS

A cross-sectional, 31-question survey was sent electronically to the 110 US hospital members of the Academic Pediatric Association’s Better Outcomes through Research for Newborns (BORN) network. Survey responses were analyzed using descriptive statistics to report frequencies. For comparisons, χ2 and Fisher exact tests were used to determine statistical significance.

RESULTS

Sixty-nine (63%) BORN nursery directors across 38 states completed the survey. For mothers with a positive cannabinoid screen at delivery, 16% of hospitals universally or selectively restrict breastfeeding. Most (96%) nursery directors reported that marijuana use while breastfeeding is “somewhat” (70%) or “very harmful” (26%). The majority was aware of the potential negative impact of prenatal marijuana use on learning and behavior. There were no consistent statistical associations between breastfeeding restrictions and provider marijuana knowledge, geographic region, or state marijuana legalization status.

CONCLUSIONS

BORN newborn clinicians report highly variable and unpredictable breastfeeding support practices for mothers with perinatal marijuana use. Further studies are needed to establish evidence-based practices and to promote consistent, equitable care of newborns with perinatal marijuana exposure.
Hacia una dimensión estética de la crítica. El tiempo de lo bello en las Cartas sobre la educación estética de Friedrich Schiller
Authors: Acosta López Maria del Rosario , Cruz Tupac
Published: January 2024

Se propone rastrear la interpretación que Schiller lleva a cabo en las Cartas sobre la educación estética del hombre del análisis kantiano del juicio de gusto puro como asociado con una suspensión de toda determinación que hace posible la experiencia de la belleza. Para Schiller, esto resulta en una temporalidad de lo bello experimentada como suspensión, que se torna adicionalmente en una suspensión de la temporalidad. El artículo muestra cómo este concepto resulta esencial para el concepto de crítica estética en Schiller, que se relaciona con una capacidad de la experiencia estética de desactivar formas de violencia que, según el diagnóstico que Schiller propone en las Cartas, saturan su presente histórico. Con ello, el artículo pretende mostrar la pertinencia de la obra de Schiller para la configuración de este aspecto de la crítica filosófica-histórica.
La relación entre el 3er conde de Shaftesbury y Johann Georg Hamann. A propósito de Sócrates y el humor
Authors: Rebelles del valle Santiago
Published: January 2024

Existe una línea temática moderna que vincula el trabajo sobre las fuentes clásicas del 3er conde de Shaftesbury con el mosaico filosófico que más tarde desarrollará Johann Georg Hamann: se trata del “proyecto socrático”, que aparece en el primero bajo la idea de unas Chartae socraticae y será motivación para que Hamann recoja el testigo en sus Memorabilia socratica. Se rastrea las raíces shaftesburianas del Sócrates de Hamann –surgidas de su lectura y traducción de juventud: Sensus communis y Carta sobre el entusiasmo– para delimitar.
Axíoco o Sobre la muerte
Authors: Donegana Lucas , Sarrat Yanina , Gutiérrez Alejandro
Published: January 2024

Este trabajo presenta la traducción de un diálogo atribuido a Platón que los estudiosos concuerdan en clasificar como apócrifo: Axíoco. Pese al carácter espurio de la obra, las temáticas desarrolladas, que a partir del interrogante de la muerte abordan cuestiones antropológicas, éticas y metafísicas, muestran una evidente vocación filosófica. Asimismo, los vínculos estructurales, conceptuales y hasta ciertas referencias intertextuales con escuelas consolidadas como el platonismo y el epicureísmo hacen que el diálogo se inscriba en una rica tradición de pensamiento cuya vigencia resulta indudable.
Effect of folic acid on isoprenaline-induced myocardial injury in rats
Authors: Sobot Tanja , Bajic Zorislava , Skrbic Ranko , Uletilovic Snezana , Mandic-Kovacevic Nebojsa , Cvjetkovic Tanja , Malicevic Ugljesa , Djukanovic Djordje , Bojic Milica Gajic , Jovicic Sanja , Barudzija Maja , Stojiljkovic Milos P. , Djuric Dragan M.
Published: January 2024

Background

Isoprenaline (ISO), a synthetic catecholamine and a β-adrenoceptor agonist, is widely used to develop an experimental model of myocardial injury (MI) in rats. The leading hypothesis for ISO-induced MI in rats is that it results from catecholamine overstimulation, oxidative stress, inflammatory responses, and development of cardiomyopathy during ISO administration. Folic acid (FA) reduces oxidative stress, improves endothelial function and prevents apoptosis, thereby contributing to cardiovascular protection. This study aimed to investigate the potentially protective effect of FA pretreatment on ISO-induced MI in rats.

Methods

For 7 days, adult male Wistar albino rats were pretreated with 5 mg/kg/day of FA. On the sixth and seventh days, MI in rats was induced by administering 85 mg/kg/day of ISO. Prooxidant markers in plasma samples, antioxidant capacity in erythrocyte lysates, cardiac damage markers, lipid profile, electrocardiography (ECG) and histopathological analysis were evaluated.

Results

FA pretreatment significantly alleviated changes induced by ISO; it decreased the homocysteine and high-sensitivity troponin I level. FA moderately decreased the reactive oxygen species (ROS) levels (superoxide anion radical, hydrogen peroxide and thiobarbituric acid reactive substances) and improved the antioxidant activities of catalase, superoxide dismutase and reduced glutathione. ISO reduced the nitrite level and FA significantly alleviated this change.

Conclusion

It can be concluded that FA, as a mild antioxidant, could be an appropriate cardioprotective substance in the rat model of ISO-induced MI.
Development of innovative tigernut-based nutritional snack by extrusion process: effects of die temperature, screw speed, and formulation on physicochemical characteristics
Authors: Kalahal Sagar Pandappa , Gavahian Mohsen , Lin Jenshinn
Published: January 2024

Tigernut (TN) is an underutilized crop with nutritional value that has remained untapped in producing extruded products. This research aims to establish the favorable extrusion conditions that produce a TN-based nutritive extruded snack with improved physicochemical characteristics. A collet extruder was used in this comparison study to examine the effects of formulation (60% TN flour and 40% brown rice [BR] vs. 60% TN flour and 40% Japonica rice [JR]). The effects of extrusion conditions, such as die temperature (90°C, 100°C, and 110°C) and screw speed (250, 300, and 350 rpm), on the physicochemical characteristics of extrudates were studied. TN-BR extrudates produced at 110°C and 350 rpm had the following improved characteristics: protein (6.09–7.33%), ash (1.40–1.59%), crude fat (7.15–9.90%), crude fiber (2.51–3.92%), reduced hardness (2.35–3.37 N), springiness (2.30–2.64), chewiness (234.71–256.72 N), bulk density (1.17–2.57 g/cm3), expansion ratio (1.65–2.24), color (L*: 68.86–74.30), water absorption index (2.69–3.45 g/g), water solubility index (13.95–21.75%), and oil absorption capacity (23.65–25.64 g/g). Extrudates produced at lower temperatures (90°C and 100°C) and screw speed (250 and 300 rpm) exhibited lesser surface consistency than the extrudates produced at 110°C and 350 rpm. The antioxidant activity and the total phenolic content (40.91–49.63 mg gallic acid equivalent/100 g) were improved significantly. Similar improvements were observed in TN-JR extrudates; however, TN-BR extrudates had better nutritional value (higher protein: 7.33%, higher ash: 1.59%, and higher antioxidant activity). The results could help with economic success, food nutrition improvement, and food security by exploiting the underutilized TN crop for sustainable extruded snacks production.
Quality assessment of black ginseng materials utilizing chemometrics and modeling inflammation in Zebrafish
Authors: Wang Lulu , Yu Meijie , Fu Yao , Li Li , Meng Xianghe , Yang Jian , He Min , Sun Mengmeng
Published: January 2024

Black ginseng is a novel variant of processed ginseng that is produced by subjecting ginseng to a series of nine steaming and drying cycles. However, the precise connection between the processing cycle and the quality of black ginseng remains uncertain, and further investigation is required to establish the association between quality markers and biological activity. In this research, high-performance liquid chromatography was employed to analyze the composition of 17 ginsenosides present in samples of black ginseng. The anti-inflammatory properties of black ginseng saponin extract were tested utilizing a zebrafish tail fin amputation model. The findings indicate that the concentrations of Rg3, Rg5, and Rk1 in black ginseng samples exhibited their highest levels following the seventh processing cycle, hence demonstrating the most effective regulatory impact on neutrophils and macrophages. This study posits that the correlation between these three ginsenoside and biological activities could potentially serve as a crucial factor in ensuring the quality control of black ginseng, thereby contributing to the advancement of quality control measures for health foods and dietary supplements that utilize black ginseng as their primary constituent.
Effects of the maximal bicycle ergometric load test on coordination abilities and functional state of cross-country skiers and biathletes
Authors:   Federal Research Centre ", Garnov Igor ,   Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences”, Loginova Tatyana ,   Federal Research Centre "Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences”, Varlamova Nina ,   Federal Research Centre "Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences”, Potolitsyna Natalya ,   Federal Research Centre "Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences”, Chernykh Aleksey ,   Federal Research Centre "Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences”, Boyko Yevgeniy ,   Federal Research Centre "Komi Scientific Centre of the Ural Branch of the Russian Academy of Sciences”
Published: January 2024

The aim of this study was to assess the influence of the bicycle ergometer endurance exercise test on the coordination abilities of cross-country skiers and biathletes in the preparatory period of the training process. 12 cross-country skiers and 11 biathletes participated in the study. The coordination test was carried out in the sitting position before and after maximal bicycle ergometer test. Reaction time was registered before endurance exercise test. For the control group, a group of university students (n = 12) of the same age and with similar anthropometric parameters was recruited. This group did not carry out the maximal cycle ergometer test. We found that time of the first coordination test in athletes was better (p < 0.01) than in the group of students. The time of the repeated coordination test was reduced in 75% participants of the control group (p < 0.05), we believe due to the development of the motor action experience. Physical exercise leads to fatigue and reduced the number of athletes who carried out the second coordination test better than the first one. Biathletes completed the maximal bicycle ergometer test with higher physiological values and recovered longer, but carried out the second coordination test faster than cross-country skiers, which was probably due to the specifics of their sport and the training process. We found strong positive correlation between reaction time and time of the first coordination test in athletes. Athletes with higher oxygen consumption during the bicycle ergometer endurance exercise were faster in the coordination test.
Updated statistical analysis of higher order aberrations and total aberrations in patients with emmetropia and refractive anomalies
Authors:   S.N. Fyodorov Eye Microsurgery Federal State Institution, Kachanov Andrey ,   I.I. Mechnikov North-Western State Medical University, Kornilov Vladimir ,   Saint-Petersburg State University, Bauer Svetlana ,   Saint-Petersburg State University, Archipova Inga ,   Saint-Petersburg State University, Zimin Boris ,   Admiral Makarov State University of Maritime and Inland Shipping
Published: January 2024

The authors performed a statistical analysis of the dependence of the total level of aberrations and the integral level of higher-order aberrations (hereafter, higher-order aberrations) depending on the type of clinical refraction and the degree of ametropia. The calculations made it possible to conclude that higher-order aberrations are characteristic of both eyes with emmetropia (“normal vision”) and eyes with ametropia (myopia and hyperopia). It turned out that the total level of eye aberrations in general directly correlates with the degree of ametropia and statistically significantly increases with an increase in the degree of ametropia (spherical component of refraction). Higher-order aberrations are practically unchanged in front of eyes with emmetropia and ametropia. According to updated data, the authors found that in the eyes with weak and moderate hypermetropia, the integral level of higher-order aberrations is higher than with myopia and emmetropia, but with a slight statistically significant difference.
Biomechanical analysis of growth stain
Authors:   Perm National Research Polytechnic University, Lokhov Valeriy
Published: January 2024

Growth strains appear mainly in living systems. Growth occurs in every living organism, and for a human it is most meaningful at childhood. Unfortunately, some children are born with congenital abnormalities, for example, with a congenital cleft of the hard palate. Without treatment and influence of the growth processes, such a child may become disabled. From the points of biomechanics and continuum mechanics, growth strains can be considered as eigenstrains. It is also known that mechanical stresses affect the growth processes, hence the growth deformation. Thus, orthodontic treatment can be considered as growth control problem. The paper uses the theorem of eigenstrain decomposition in a linear elastic body, which allows us to decompose the eigenstrain into two parts: stress-free (or impotent), and deformation-free (or nilpotent). The paper shows the application of the theorem in the solution of stress-free deformation control by eigenstrain, the statement of a problem of modelling of systems with eigenstrain is given. The proposed approach is used to simulate growth deformations in the treatment of congenital cleft of the hard palate. The governing equation for the growth strain is discussed and analyzed, and it is shown that under certain boundary conditions the growth will not cause stresses in the system, which greatly simplifies the solution for the problem of growth strain accumulation over time. This result is important for planning the optimal orthopedic treatment of the pathology, which leads to the problem of independent control of system deformations by means of growth strains. The governing equation is obtained for an isotropic homogeneous body, since the bone tissue of the child has no formed structure and isotropic.
Positivity-based stability analysis in testosterone regulation using distributed feedback control
Authors:   Ariel University, Pinhasov Olga
Published: January 2024

A model describing testosterone regulation by distributed input feedback control is considered. It is aimed to hold testosterone concentration above a corresponding level. The distributed feedback control with integral term is proposed. This leads us to analysis of an integro-differential system which describes the connection between the concentration of hormone GnRH, the concentration of the hormone LH and the concentration of testosterone Te. We propose controls in the form of integral operators, i.e. distributed feedback controls, which allows us to hold a suitable testosterone level without loss stability of the biological system.
Births: Final Data for 2022
Authors: Osterman Michelle , Hamilton Brady , Martin Joyce , Driscoll Anne , Valenzuela Claudia
Published: January 2024

This report provides health data from the National Center for Health Statistics.
Human Papillomavirus Vaccination Coverage in Children Ages 9–17 Years: United States, 2022
Authors: Villarroel Maria , Galinksy Adena , Lu Peng-Jun , Pingali Cassandra , Valenzuela Claudia
Published: January 2024

This report provides health data from the National Center for Health Statistics.
Pedagogical conditions for increasing the well-being of future sports teachers by means of china's sports culture
Authors:   Ural Federal University, Yekaterinburg, Russia, Yu Itsun , Rogaleva L. N. ,   Ural Federal University, Yekaterinburg, Russia, Yamaletdinova G. A. ,   Humanities University, Yekaterinburg, Russia
Published: January 2024

The aim of the study was to substantiate the pedagogical conditions for increasing the psychological well-being of future sports teachers using the sports culture of China. In total, 27 students of the direction 49.03.01 – Physical Culture of the Ural Federal University took part in the study. K. Rieff's method was used to assess the level of psychological well-being. At the first stage of the experimental work, we developed a course “Fundamentals of Chinese Sports Culture,” which included 3 modules. To conduct the experimental study, pedagogical conditions were developed aimed at increasing the well-being of future sports teachers, which were clarified during the experiment. The results of the experimental work showed interest in the new course and readiness to master the means of Chinese sports culture; the classes contributed to an increase in the level of psychological well-being.
Features of the manifestation of anxiety in highly qualified athletes
Authors:   Ural Federal University, Yekaterinburg, Russia, Protasov E. A. , Pshenitsyn K. K. ,   Ural Federal University, Yekaterinburg, Russia
Published: January 2024

The aim of the research was to study anxiety of highly qualified athletes. Methods. 41 athletes with high sports qualifications participated in the study. The athletes were representatives of more than 20 sports, which were considered cyclic and acyclic, individual and team. In the course of the study, the following methods were used: "Assessment of situational and personal anxiety" (C.D. Spielberger – Y.L. Khanin), "Self-assessment of mental states" (G. Aizenk). The studies have found that highly qualified female athletes have higher rates of general anxiety, frustration and rigidity (p = 0.01). Personal anxiety is higher in cyclical sports athletes (p ≤ 0.01). It is at odds with other studies, but proves the role of a personal factor in influencing anxiety, and not only the kind of sport. The frustration of athletes is significantly higher in team sports compared to individual sports (p ≤ 0.05), due to the higher uncertainty of achievement of results. The limitations of the study included an insufficient sample of athletes. Further research may be aimed at identifying the personal predicates of anxiety in highly qualified athletes.
Motivation for independent physical education among university students
Authors:   Ural Federal University, Yekaterinburg, Russia, Fassakhova T. A. , Dobrynin I. M. ,   Ural Federal University, Yekaterinburg, Russia
Published: January 2024

The article is devoted to the definition motives that determine the orientation of independent physical exercises for students and identifying limiting factors that prevent students from engaging in physical activity. A questionnaire survey of students of the Ural Federal University was conducted. The study involved 1,047 people aged 18-21 years. The study has shown that the main motives for self-exercise are the desire to maintain health throughout life (wellness motive). Slightly fewer respondents engage in physical exercise in order to gain additional self-confidence and transform their appearance (aesthetic motive). Also, the data from the questionnaire suggest that at this age there is still no need for the effects of physical exercise on the body, health, efficiency because a beautiful physique is perceived as a given and physical education is not perceived as a means of improving the quality of life.
Meditation as a means of prevention psychological and physical stress
Authors:   Ural Federal University, Yekaterinburg, Russia, Prikashchikova I. V.
Published: January 2024

The purpose of the study was to review the literature on the role of meditation in the prevention of psychological and physical stress. A review of the literature has shown that there are differences in views on meditation in the cultures of the East and West. Modern research has two directions: the first is related to the study of the mechanism of action of meditative practices on the body of students, and the second direction is related to the development of meditation programs and the study of its positive effects in the prevention of psychological and physical stress. Further research should be aimed at developing and testing programs for students to use meditation to reduce stress level and increase awareness of their actions.
Psychological characteristics of athletes-track and field athletes with DMCS depending on their sports qualifications
Authors:   Ural Federal University, Yekaterinburg, Russia, Tretyakova E. D. , Rogaleva L. N. ,   Ural Federal University, Yekaterinburg, Russia, Belyaeva V. V. ,   Lyceum, Ural Federal University, Yekaterinburg, Russia
Published: January 2024

The purpose of the research is related to the study of the psychological characteristics of track and field athletes of different levels of athletic qualifications who have musculoskeletal system damage. In total, 22 athletes participated in the study. The first group included Paralympic athletes of the highest skill level (members of the national teams of Russia, Masters of Sport, World Class Sport Masters), the second group included athletes of lower grades (the first grade, Candidates for the Master of Sports). The research methods: the method of "Locus of control" by J. Rotter, Salvatore Maddi's resilience test adaptation in the version of D. Leontiev, a technique for diagnosing stress (K. Schreiner), K. Lusin's emotional intelligence test. The results of the study revealed significant differences in locus control depending on the level of sports qualification (p≤0.01). The athletes with higher grades have more noticeable internality, and most of all in terms of individual achievements. For athletes of lower grades, the external locus of control is more characteristic. Reliable direct correlations of the internal locus of control with indicators of resilience, such as engagement and control have been revealed. A negative relationship between the external locus of control and the resilience of track and field athletes with musculoskeletal system damage has also been revealed. The revealed facts allow to build the right psychological work with athletes, aimed both at improving the psychological training of athletes and at organizing the educational and training process.
Sex differences in type 2 diabetes genetic susceptibility
Authors: Avzaletdinova D. S. , Morugova T. V. , Kochetova O. V.
Published: January 2024

Introduction. In the last few years gender and sex differences in type 2 diabetes (T2D) predisposition are paid much attention. This gap can be caused by the hormonal and genetic background and require further traits.

Aim. The aim of this study was to identify genetic markers of T2D predisposition depending on sex using 17 polymorphic markers of genes involved in various links of T2D pathogenesis.

Material and Methods. 536 patients with T2D and 1,476 healthy individuals were examined. Amplification of 17 polymorphic gene loci was performed by polymerase chain reaction. Associations of DNA polymorphisms with T2D were evaluated by logistic regression using the SNPStats program. The degree of association was assessed in the odds ratio (OR) scores. Correction for multiplicity of comparisons and multivariate analysis was used.

Results. The genotypes of increased T2D risk for men are CC of CCL20 rs6749704 marker (OR = 3.85, P = 0.0002) in recessive model, D/I of CCR5 rs333 marker (OR = 4.42, P = 0.0208); by GRIA1 marker rs2195450 - CT and TT in the dominant model (OR = 2.42, P = 0.0002), TT - in the recessive model (OR = 2.89, P = 0.0070). The genotypes of increased risk of T2D in women according to the marker TCF7L2 rs7903146 - CT and TT in the dominant model (OR = 1.69, P = 0.0003), TT - in recessive (OR = 1.61, P = 0.0124), according to the marker ADIPOQ rs17366743 - TC (OR = 2.55, P = 0.0168).

Conclusion. The established genotypes of increased T2D risk depending on gender make it possible to personalize approaches to primary T2D prevention.
Improved perception of IGLARLIXI therapy compared to mixed insulin when transferred from basal insulin: outcomes reported by patients in the SoliMix study
Authors: Yanovskaya E. A. , Yanovskaya M. E.
Published: January 2024

Since type 2 diabetes mellitus (DM2) is characterized by a progressive loss of pancreatic beta cell function, there is a need to add insulin to current therapy in order to compensate for the disease and prevent the development of complications. The clinical recommendations suggest various options for the intensification of DM2 therapy: both monopreparations of insulin and its combination with aGPP-1. The latter have demonstrated clinical efficacy in achieving glycemic control and a favorable safety profile in clinical trials. Another important issue is the perception of treatment by the patient himself, since for many people, changing therapy or changing the “format” itself (prescribing injections) can be accompanied by additional stress.

The purpose of this study was to study the efficacy and safety, as well as the perception of patients with treatment of DM2 when using a fixed combination of insulin glargine/lixisenatide (Iglarlixi) compared with mixed insulin – biphasic aspartame 30.
Metabolic, zootechnical, and health profile of Girolando calves conceived through in vitro fertilization
Authors: Weiller Maria Amélia Agnes , Schmoeller Evandro , Barbosa Antônio Amaral , Matos Adriane Dalla Costa de , Brauner Cassio Cassal , Corrêa Marcio Nunes , Pino Francisco Augusto Burkert Del , Rabassa Viviane Rohrig
Published: January 2024

ABSTRACT: This study determined the zootechnical, metabolic, and health performance of Girolando calves born with high or low birth weight, conceived through in vitro fertilization. The study was carried out on a commercial dairy farm located in Passos, Minas Gerais, Brazil. For this, a hundred Girolando calves were divided into two groups: The Control, which consisted of calves that were born weighing ≤ 35 kg; and high birth weight (HBW) calves, which were born weighing > 35 kg. The calves were monitored for zootechnical parameters; epidemiological indices, for diseases such diarrhea and pneumonia; as well as serum concentrations of aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, cholesterol, triglycerides, paraoxonase1, albumin, urea, and globulin. Calves from the HBW group had a higher general mortality rate, but no effects on the zootechnical performance or metabolism were observed. The results obtained allow us to conclude that Girolando calves generated by IVF and heavier at birth have a greater chance to present diseases such as omphalophlebitis, tympany, and bovine parasitic sadness, and have a higher rate of general mortality. Conversely, birth weight of the calves does not influence diarrhea or pneumonia, the zootechnical performance, or the metabolism.
“Diários de cirurgia”: corpos, subjetividades e intimidades digitalizadas
Authors: Rohden Fabíola , Cavalheiro Camila Silveira
Published: January 2024

Resumo Os chamados diários de cirurgia são um tipo de conteúdo relativamente recente na internet e nas redes sociais. Trata-se de vídeos nos quais influenciadoras digitais brasileiras narram as suas experiências de realização de cirurgias estéticas, como o implante de próteses de silicone nos seios e a lipoaspiração. Argumenta-se neste artigo que esse material ilustra um tipo particular de digitalização da vida. A intimidade do processo cirúrgico, bem como expectativas, sentimentos e sensações são apresentados em um formato audiovisual destinado a ser compartilhado com um grande número de “seguidores”. Esse fenômeno é analisado considerando as discussões sobre aprimoramento, exposição pessoal, gênero e transformações corporais e subjetivas.
Prevalence and factors associated with the death of older people hospitalized due to Covid-19 in the state of Paraná
Authors: Inoue Luiz Hiroshi , Baccon Wanessa Cristina , Pesce Giovanna Brichi , Pereira Natan David , Silva Isabela Vanessa Tavares Cordeiro , Salci Maria Aparecida , Vissoci João Ricardo Nickenig , Facchini Luiz Augusto , Carreira Lígia
Published: January 2024

ABSTRACT Objective: To estimate the prevalence and to analyze the factors associated with the death of older people hospitalized due to Covid-19 in the state of Paraná. Method: Cross-sectional study conducted with secondary data from older people with a positive diagnosis of Covid-19 living in the State of Paraná, collected from March 1, 2020 to August 31, 2021. Prevalence ratios were obtained by adjusting the regression model. Results: A total of 16,153 deaths of older people hospitalized in the State of Paraná were analyzed. The adjusted model revealed an association between death and some factors such as: belonging to the age group of 75 to 84 years (PR = 1.28; CI95% = 1.24–1.32) and 85 years or over (PR = 1.52; CI95% = 1.45–1.59); male (PR = 1.17; CI95% = 1.13–1.21); obesity (PR = 1.23; CI95% = 1.16–1.29); other morbidities (PR = 1.25; CI95% = 1.20–1.30); and having used ventilatory support (PR = 2.60; CI95% = 2.33–2.86). Older people vaccinated against influenza had a probability of death reduced by 11% (PR = 0.89; CI95% = 0.86–0.93). Conclusion: The association of age, sex, and diagnosis of previous comorbidities with unfavorable outcomes from Covid-19 was identified. Having received the flu vaccine provided protection to elderly people who contracted SARS-CoV-2.
Metodologia da problematização no ensino remoto para debater sobre infecções sexualmente transmissíveis em idosos
Authors: Sales Ítalo Xavier dos Santos , Andrade Alex Muniz de , Lima Matheus Martins de , Oliveira Vinícius José de
Published: January 2024

Resumo Introdução: Atualmente o Brasil mostra um expressivo aumento da sobrevida e consequente elevação do número de idosos na sua população. Do ponto de vista de propostas para a melhoria da qualidade de vida deles, a sexualidade deve ser compreendida a partir do princípio holístico, não somente do fator biológico. Nesse cenário, novas reflexões de profissionais da saúde tornam-se indispensáveis para o planejamento de ações específicas, objetivando a atenção integral à saúde do idoso. Relato de experiência: O presente relato de experiência traz o início de um diálogo com acadêmicos de Medicina de uma universidade pública sobre a complexidade da sexualidade e infecções sexualmente transmissíveis (IST) em idosos, buscando identificar o conhecimento desses discentes sobre o assunto e idealizar propostas de ação ao público-alvo. Para isso, estruturou-se uma estratégia de ensino-aprendizagem cuja abordagem consistiu na adaptação e aplicação da metodologia do Arco de Maguerez para o debate sobre IST no contexto da saúde pública brasileira, o qual foi realizado com base nas diretrizes do ensino remoto emergencial. Nossos resultados vão de encontro à literatura que visa compreender as representações sociais acerca da sexualidade dos idosos. Neles, verificou-se que as representações sociais acerca da sexualidade na terceira idade assemelham-se à descrição científica, apresentado similitude entre o senso comum e o conhecimento erudito. Discussão: Diante da discrepância descrita na literatura quanto aos conceitos errôneos por parte dos idosos e dos familiares e pelos profissionais de saúde acerca da sexualidade na terceira idade, são imprescindíveis a realização de campanhas e o desenvolvimento de medidas e estratégias preventivas voltadas para idosos, a fim reduzir a incidência de IST nessa comunidade. Para isso, são fundamentais estratégias de educação em saúde no ensino acadêmico e de educação profissional continuada para sedimentar os conhecimentos necessários na idealização de propostas eficazes. Conclusão: A partir da formação médica adequada e por meio da discussão dos aspectos complexos sobre o assunto, serão possíveis a construção, a implementação e a avaliação de políticas públicas de saúde para o enfrentamento das IST, de modo a diminuir as barreiras relacionadas à prevenção de doenças e à promoção de saúde sexual na população idosa.
Conhecimento de uma amostragem da população brasileira sobre a função da creatinina sérica
Authors: Cerqueira Bruno Pellozo , Rocha Júlia Ferreira , Barnes Rafaela Francisquetti , Pepato Pedro Henrique Moretti , Paim Thays Sellan , De Nardi Francisco , Hsu Fabrício Akira , Oguma Juliana Miki , Ito Leticia Miyuki , da Silva Enio Yasuhiro Arimatsu Policarpo , Vizzuso-Oliveira Alexandre , Filho Fernando Diniz dos Santos , Maia João Vitor Bozza , Mendez Juan Diego Zambrano , Sato Beatrice Borges , Souza Roberto Matias , Miyahara Andre Kiyoshi , Kirsztajn Gianna Mastroianni
Published: January 2024

Resumo Introdução: A doença renal crônica costuma ser assintomática e seu diagnóstico depende da realização de exames laboratoriais, com destaque para a creatinina sérica e pesquisa de proteinúria. Objetivo: Avaliar em uma amostra da população brasileira o conhecimento sobre o papel da creatinina sérica como marcador de função renal. Método: Estudo observacional transversal realizado na cidade de São Paulo (SP, Brasil), em que foi entrevistada uma população adulta aleatória. Resultados: Foram entrevistados 1138 indivíduos, com idade mediana de 36 anos (27–52); 55,1% do sexo feminino. Com relação ao marcador “creatinina”, 40,6% afirmaram que nunca realizaram tal dosagem. Quando questionados quanto ao conhecimento sobre a utilidade desse exame, somente 19,6% sabiam a sua função. As outras respostas foram “não sei” (71,6%), avaliar o funcionamento do coração (0,9%) e fígado (7,8%). Dos que afirmaram já terem realizado o exame de creatinina, somente 29,4% acertaram a função da creatinina. Ao dividir os grupos em “sabe” e “não sabe” a função da creatinina, percebeu-se diferença estatisticamente significante (p < 0,05) em relação ao grau de escolaridade, sexo feminino, ser aluno/trabalhador da saúde, ter dosado creatinina alguma vez, conhecer alguém com doença renal e maior idade. Na análise multivariada, a principal variável relacionada com conhecer a função da creatinina foi ter realizado o exame anteriormente (OR 5,16; IC 95% 3,16–8,43, p < 0,001). Conclusão: Há grande desconhecimento sobre a creatinina e seu uso em check-ups. Os resultados indicam que é necessário maior esforço por parte dos profissionais de saúde para divulgar o papel da creatinina sérica.
The effect of constraint-induced movement therapy assessed by accelerometry: the impact on daytime activity and sleep in children with cerebral palsy
Authors: Almeida Marcela Fischer de , Obrecht Andrea , Zonta Marise Bueno , Crippa Ana Chrystina
Published: January 2024

Abstract Introduction Spastic hemiparetic cerebral palsy (CP) is the most prevalent type of CP. Children with spastic hemiparesis experience difficulties when using their affected upper extremities, and one effective treatment is the Constraint-Induced Movement Therapy (CIMT). The study of rest-activity patterns provides information on children’s daily activities with spastic hemiparetic CP during the day and sleep. Objective To investigate the effect of CIMT on the rest-activity patterns in children with spastic hemiparetic CP vs in a healthy group. Methods Nonrandomized controlled trial was conducted at the Neuropediatric Center of the Hospital de Clínicas Complex, in Curitiba, Brazil. Children with spastic hemi-paretic CP between 5 and 16 years old participated in the study group and receive the CIMT. The healthy group was composed of children between 5 and 15 years old. Both groups used accelerometer to record rest-activity patterns, that may be studied through nonparametric variables of accelerometer: M10 (an individual’s most active 10h); L5 (an individual’s least active 5h); and RA (relative amplitude of the circadian rest-activity patterns). Results Forty-five children were recruited, and 38 were included in the analyses (19 allocated to each group). In the study group, there was a significant increase in M10 and L5 (p < 0.001) after CIMT. The values of M10 and L5 were significantly higher (p < 0.001) in the healthy group compared to the study group after CIMT. Conclusion Our results showed that children with spastic hemiparetic CP became more active and participant in their daily life during the day as well as more efficient sleeping.
Inclusão da espiritualidade do paciente durante o tratamento quimioterápico
Authors: De La Longuiniere Agnes Claudine Fontes , Yarid Sérgio Donha
Published: January 2024

Resumo A relação da espiritualidade com a saúde tem sido estudada e apontada como uma dimensão que traz benefícios na promoção, proteção e recuperação, além de colaborar com o enfrentamento de doenças. Assim, o objetivo deste estudo é relatar uma experiência vivenciada durante um ensaio clínico randomizado, que incluiu a dimensão espiritual do paciente no tratamento contra o câncer, a partir da realização de uma pesquisa que incluiu a espiritualidade do paciente oncológico durante o processo quimioterápico. O ensaio clínico foi composto por 30 pacientes portadores de câncer atendidos em uma Unidade de Assistência de Alta Complexidade em Oncologia. Percebeu-se que eles demonstraram surpresa por terem sua dimensão espiritual incluída, relatando que era uma questão importante para vivenciarem o que estavam passando. Também se notou a importância de incluir estudantes de medicina na coleta dos dados, oportunizando aos futuros profissionais contato com essa temática no contexto do cuidado em saúde. A vivência de experiências que trazem questões tão subjetivas, delicadas, profundas e essenciais sobre o ser humano, como são a espiritualidade e a fé, permitiu ao pesquisador desenvolver uma reflexão sobre a necessidade de mudança de paradigma na forma de prestar cuidado à saúde.
Considerações sabre a Conjectura de Collatz
Authors: Loris Audemir
Published: January 2024

Parte da comunidade cientifica tem dispendido considerável tempo e recursos para de alguma forma validar a conjectura de Collatz, inúmeros esforços tem logrado considerável avanço nesta direção, porém tal conjectura carecia de uma confirmação definitiva de que escolhido um número impar qualquer xi ∈ N∗, obteremos x(i+1) = 3xi + 1, sendo este um número x(i+1) par, divide-se o mesmo pelo número dois (sucessivamente) até obter-se outro número impar ∈ N∗ , repete-se o processo xn = 3x(n−1) + 1 e divisões por dois até que resulte finalmente um número igual 1.Neste trabalho apresentam-se deduções, algoritmos e equações que corroboram com tal proposição, embasam tal percepção e conclusão de que a conjectura de Collatz aponta para o ciclo final 4 → 2 → 1.
Paradoxo Eleitoral: Os Outros Sempre Escolhem Por Você
Authors: Pires Pedro Serafim Anes , Obadowski Vinícius Novicki
Published: January 2024

O presente ensaio consiste de uma minuciosa análise crítica das premissas dogmáticas por trás da legislação eleitoral brasileira a retórica oficial das autoridades, veiculada pela Justiça Eleitoral por meio de propaganda e coerção legal. Valendo-se como principal paradigma metodológico a teoria da escolha pública (public choice theory), pragmática e imparcial, é desenvolvida a argumentação ao redor do paradoxo identificado pelo economista Anthony Downs, corolário da discrepância entre a utilidade individual do voto e utilidade pública, atrelada à probabilidade de um voto decidir uma eleição; paradoxo examinado no contexto da democracia brasileira. Os argumentos apresentados têm por base dados objetivos, princípios da teoria da informação, estatística e cálculo probabilístico, apresentados de forma acessível, primariamente expositiva, acerca do funcionamento do sistema eleitoral e da comunicação governamental, concluindo com considerações normativas.
Different Doses of Dexmedetomidine Reduce Postoperative Sleep Disturbance Incidence in Patients under General Anesthesia by Elevating Serum Neurotransmitter Levels
Authors: Lu Huifei , He Fei , Huang Ying , Wei Zhongliang
Published: January 2024

Postoperative sleep disturbance is a common issue that affects recovery in patients undergoing general anesthesia. Dexmedetomidine (Dex) has a potential role in improving postoperative sleep quality. We evaluated the effects of different doses of Dex on postoperative sleep disturbance and serum neurotransmitters in patients undergoing radical gastrectomy under general anesthesia. Patients were assigned to the control, NS, and Dex (Dex-L/M/H) groups based on different treatment doses [0.2, 0.4, and 0.6 μg/(kg · h)]. The Athens Insomnia Scale (AIS) and ELISA kits were used to assess sleep disturbance and serum neurotransmitter (GABA, 5-HT, NE) levels before surgery and on postoperative days one, four, and seven. The effects of different doses on postoperative sleep disturbance incidence and serum neurotransmitter levels were analyzed by the Fisher exact test and one-way and repeated-measures ANOVA. Patients had no differences in gender, age, body mass index, operation time, and bleeding volume. Different Dex doses reduced the postoperative AIS score of patients under general anesthesia, improved their sleep, and increased serum levels of 5-HT, NE, and GABA. Furthermore, the effects were dose-dependent within the range of safe clinical use. Specifically, Dex at doses of 0.2, 0.4, and 0.6 μg/(kg · h) reduced postoperative AIS score, elevated serum neurotransmitter levels, and reduced postoperative sleep disturbance incidence. Collectively, Dex has a potential preventive effect on postoperative sleep disturbance in patients undergoing general anesthesia for radical gastrectomy. The optimal dose of Dex is between 0.2 and 0.6 μg/(kg · h), which significantly reduces the incidence of postoperative sleep disturbance and increases serum neurotransmitter levels.