bluuebunny/crossref_metadata_2025 huggingface dataset:
Berberine prevents the formation of aortic dissection in C57BL/6 mice through the regulation of vascular smooth muscle cell function
Authors: Wu Tongyi , Chen Ru , Ban Wuyi , Ren Chang , Bi Siwei , Gu Jun , Geng Zangjia , song lei
Published: October 2024

Purpose
Aortic dissection (AD) represents a critical medical condition characterized by a high mortality rate and limited therapeutic options. The pathogenesis of AD is associated with the extracellular matrix degradation, phenotypic switching and the loss of vascular smooth muscle cells (VSMCs). Berberine (BBR) has demonstrated promising protective effects in various cardiovascular diseases, but its impact on AD and the underlying mechanisms remains unexplored. This study aims to investigate the potential of BBR in reducing the development of AD and preventing the phenotypic transformation of VSMCs, thereby proposing a novel therapeutic strategy for this life-threatening condition.
Methods
C57BL/6J mice and isolated VSMCs were used as in vivo and in vitro models, respectively. An AD mouse model was established through intragastric administration of β-aminopropionitrile monofumarate (BAPN), and VSMC phenotypic transformation was induced by angiotensin II (Ang-II) to assess the preventative effects of BBR.
Results
BBR significantly mitigates AD in a BAPN-induced mouse model by reducing AD incidence from 80–45% and increasing survival rates from 50–70%. BBR treatment alleviates aortic dilation and improves aortic morphology, while also attenuating extracellular matrix degradation, as evidenced by reduced collagen type I and fibronectin degradation. Histological and immunohistochemical analyses reveal that BBR diminishes inflammation, as indicated by reduced IL-6 and HIF-1α expression, and mitigates oxidative stress by lowering MDA levels and enhancing SOD activity. Additionally, BBR counteracts VSMC phenotypic transformation and apoptosis, demonstrated by restored contractile protein levels and reduced caspase-3, AKT, and PI3K levels. It also inhibits VSMC proliferation, migration, and MMP expression in vitro, highlighting its protective role against AD progression.
Conclusion
BBR exhibits protective effects against BAPN-induced AD in C57BL/6J mice, highlighting its potential as a viable and innovative therapeutic option for preventing AD progression.
The Maternal and Sibling Spillover Effects in Educational Attainment
Authors: Farzana Sadia , Song Suyong
Published: October 2024

This study rigorously examines educational spillovers within families using Inverse Prob- ability Weighted Regression Adjustment, Propensity Score Matching, and an innovative In- strumental Variable strategy. We find that children whose mothers have more than 12 years of schooling gain approximately 0.385 to 0.396 years of schooling, while younger siblings of firstborns with over 12 years of schooling gain 0.505 years. IV regressions further suggest that each additional year of maternal education leads to a 0.367-year increase in children’s schooling, and each additional year of firstborn’s education results in a 0.333-year gain for younger siblings. These results, robust across multiple estimation techniques, underscore the significant role of maternal and sibling education in shaping children’s outcomes. This study advances methodological approaches, enriches the literature on family influences in education, and offers new insights into the mechanisms driving educational attainment within families.
JEL classification: I21, I25, J13, J24
Effect of intravenous lidocaine infusion on postoperative pain and inflammatory factors in patients undergoing thoracic surgery
Authors: Xu Lulu , Zhou Yong , Jiang Xueqing , Ni Jun , Feng Chaonan
Published: October 2024

Objective
To observe the effects of intravenous lidocaine infusion on postoperative pain and inflammatory factors in patients undergoing thoracic surgery.
Methods 120 patients undergoing thoracoscopic lobectomy were randomly divided into groups A, B and C, with 40 cases in each group. Group A received intravenous lidocaine 1.0 mg/kg during anesthesia induction, continued to pump lidocaine 1.5 mg/kg•h during the operation until the end of the operation, and continued to pump lidocaine 0.2 mg/kg•h after surgery until 48 hours after surgery; Group B received intravenous lidocaine 1.0 mg/kg during induction of anesthesia and continued to pump lidocaine 1.5 mg/kg•h during operation until the end of operation; Group C was given equal volume of normal saline. VAS pain scores were recorded after extubation, 30 min after extubation, when leaving PACU, 24 h after surgery and 48 h after surgery. Coughing during extubation, postoperative nausea and vomiting, additional postoperative analgesics, number of analgesic pump compressions, first time to exhaust gas, first time to get out of bed, length of hospital stay and postoperative QoR15 score were measured. Serum levels of procalcitonin and IL-6 were measured by intravenous blood samples before and 48 h after operation.
Results Compared with group C, VAS scores in group A and group B were significantly decreased 30min after extubation, after leaving PACU, 24h and 48h after surgery (P < 0.017). The incidence of coughing during extubation was decreased (P < 0.05), the first time of getting out of bed was significantly shortened (P < 0.017), the levels of procalcitonin and IL-6 were significantly decreased 24h after extubation (P < 0.017), and the score of QoR15 was significantly increased (P < 0.017). There were no significant differences in VAS score after extubation, incidence of postoperative nausea and vomiting, additional analgesic drugs and the number of analgesic pump compression, first postoperative exhaust time and postoperative hospital stay among three groups (P > 0.05).
Conclusion
Intravenous infusion of lidocaine can effectively relieve postoperative pain and reduce the level of postoperative inflammatory factors in patients undergoing thoracic surgery.
Trial registration Chinese Clinical Trial Registry, ChiCTR2300078858, 20/12/2023.
Assessment of patient satisfaction with pharmacy service and associated factors at community pharmacies in Debre Tabor Town, Northwest Ethiopia
Authors: Addis Getu Tesfaw , Tadesse Tesfaye Yimer , Addis Eyerus Tesfaw , Moges Tilaye Arega , Ayele Teklie Mengie , Dagnew Samuel Berihun
Published: October 2024

Background
One of the main ways to assess how well healthcare is being delivered is through patient satisfaction. When visiting community pharmacy, patients express a clear desire for high-quality care. But if their needs aren't well identified, the patient could not be satisfied. When a patient is happy with their pharmaceutical care, they are more likely to follow through on their prescription regimens, seek out medical assistance, and adhere to it. One strategy to raise customer satisfaction with healthcare services is to make quality pharmacies more accessible. Consequently, the purpose of this study was to assess patient satisfaction with pharmacy services at a community pharmacy in Debre Tabor city, North West Ethiopia, 2024.
Methods and materials:
A cross-sectional study were conducted among 405 respondents to assess satisfaction with pharmacy service in community pharmacy located in northwestern Ethiopia from February to March 2024. Data were collected through an exit interview using structured questionnaires. Then, it was entered into EpiData version 3.1 and exported to Spss version 23 for analysis. Associations between dependent and independent variables were assessed by multiple logistic regression using an adjusted odds ratio at a 95% confidence interval and the p values of less than 0.05.
Result
Four hundred five participants agreed to finish the study. The total satisfaction rate for community pharmacy services was 62.7%. The pharmacist does not provide information on how to deal with drug side effects that may develop at any time, which was the primary source of dissatisfaction (46.4%). Client satisfaction was adversely associated with an uncomfortable waiting area (AOR = 5.67, 95% CI: 1.18–27.22), an unfair medicine cost (AOR = 1.6, 95% CI: 0.90–2.82), and Age (AOR = 9.55, 95% CI: 3.17–28.80).
Conclusion
The level of customer satisfaction with pharmacy services was reported to be greater than 50%. The area of residence, educational status, and drug availability have no association with their level of satisfaction, but their perception of uncomfortable waiting areas, unfair medication costs were negatively associated with their satisfaction.
Delta Neutrophil Index in Coronary Artery Bypass Surgery: An Innovation in Postoperative Mortality Assessment
Authors: Bilgiç Abdulkadir , Toprak Burak , Kaya Hamide , Toprak Çise Kanat
Published: October 2024

a. Background:
Recently, the role of inflammatory markers in assessing the severity of CAD in the early stages has garnered interest. Currently, there are no specific inflammatory biomarkers routinely used for predicting postoperative mortality in patients undergoing coronary artery bypass grafting (CABG). In this study, we evaluated the significance of postoperative DNI as a prognostic marker for early mortality in patients undergoing coronary artery bypass grafting (CABG).
b. Aims:
The aim of this study is to determine the significance of the delta neutrophil index (DNI), which reflects the proportion of immature granulocytes, as a prognostic marker for early postoperative mortality in coronary artery bypass grafting (CABG).
c. Methods:
This rigorously designed retrospective cohort study, conducted at a high-volume tertiary care center specializing in cardiovascular surgery, included a robust patient cohort to ensure comprehensive data analysis and reliable conclusions. The study included a consecutive series of 446 patients who underwent coronary artery bypass grafting (CABG) between January 1, 2022, and August 1, 2023.
d. Results:
Mortality was found to be associated with Pre-DNI (p < 0.05). A 1-unit increase in Pre-DNI measurement was associated with a 2.61-fold (95% Confidence Interval: 1.54–4.45) increase in the risk of death. Additionally, mortality was also associated with Post-DNI (p < 0.05). A 1-unit increase in Post-DNI measurement was associated with a 10.21-fold (95% Confidence Interval: 5.08–20.05) increase in the risk of death.
e. Conclusions:
This study unequivocally establishes that elevated DNI values serve as potent independent predictors of postoperative mortality, underscoring the clinical utility of DNI as a key component in the perioperative risk stratification for CABG patients. Both preoperative and postoperative DNI were significantly associated with mortality, highlighting the valuable role of DNI in risk assessment necessary for perioperative and postoperative management. This highlights the dual utility of DNI in not only predicting but also monitoring patient outcomes throughout the perioperative period. Incorporating DNI into routine clinical practice could provide a more personalized approach to postoperative care, potentially improving patient survival and reducing complication rates in CABG surgery.
GSH-responsive and Mitochondria-targeting Multifunctional Nanoplatform for MR imaging-guided enhanced chemotherapy of Glioma by Reshaping the Tumor Immune Microenvironment
Authors: Zheng Guangrong , Ke Tengfei , Zhao Wen , Shan Haiyan , Li Guochen , Yang Xingyu , Ouyang Zhiqiang , Wang Hongjin , Yang Haiyan , Liao Chengde
Published: October 2024

Despite considerable progress in glioma research, present therapeutic approaches continue to be insufficiently efficacious, predominantly owing to challenging hindrances in conveying chemotherapy drugs across the blood-brain barrier (BBB) and reshaping the immunosuppressive tumor microenvironment (TME). In this study, a multifunctional nanoplatform was developed comprising poly-lactide-co-glycolide (PLGA) encapsulated with MnO2 nanoparticles, triphenylphosphonium (TPP) conjugated with doxorubicin (DOX), and Angiopep-2 (Ang) for the magnetic resonance imaging-guided enhanced chemotherapy of glioma. The role of Ang promotes BBB penetration and tumor cell targeting, while TPP allows for an increased concentration of the Ang-PMT NPs in the mitochondria. Upon exposure to high concentration of glutathione (GSH) within the TME, the Ang-PMT NPs disintegrate rapidly, resulting in the production of Mn2+ and the subsequent release of DOX. The released DOX directly eradicates tumor cells and catalyzes mitochondrial DNA release, leading to immunogenic cell death (ICD) and the activation of the cGAS-STING pathway. Furthermore, the produced Mn2+ also activates the cGAS-STING pathway, thereby reshaping the TME and enhancing chemotherapy for glioma. The multifunctional nanoplatform demonstrated a notable inhibition of tumor growth in comparison to the control groups. It is anticipated that this innovative approach may offer promising prospects for the management of malignant glioma in clinical management.
Tropical cyclones modulate drought characteristics in the Hurricane Region of the Americas
Authors: Herrera Dimitris , Dominguez Christian , Centella Abel , Sánchez-Murillo Ricardo , Pons Diego , Hidalgo Hugo , Sierra-Lorenzo Maibys , Cook Benjamin , Bregy Joshua , Bezanilla Arnoldo
Published: October 2024

Drought and tropical cyclones (TCs) are among the deadliest and costliest natural hazards, and they are expected to intensify in the twenty-first century because of anthropogenic climate change. The Hurricane Region of the Americas (HRA), an area often impacted by TCs and drought of the Americas, hosts some of the most vulnerable countries to these hazards and climate change worldwide. While TCs and drought have been extensively studied separately, there is little research on their interplay in the HRA, especially in areas without quality, long climate data. Here, we analyze the effects of TCs on drought characteristics (e.g., severity and duration) in the HRA between 1985 and 2023 using high-resolution gridded climate data and an array of drought metrics. Our results yield the first-of-its-kind estimate of the interplay between TCs and drought across the entire HRA. We find that, while TCs contribute to 4–15% of annual and seasonal mean precipitation across the region, on average, they ameliorated or terminated drought (e.g., an improvement of at least one drought rank on each metric) at least once in ~ 60% of the HRA in a single month in 1985–2023 (averaged estimates from all drought metrics). We suggest an appropriate analysis of TC-drought interactions should consider several drought metrics, even if sophisticated land-surface models are used.
A Panel Data Analysis of the Net Zero trajectory of Seven Industrialized Economies.
Authors: Alemzero David , Darimeh Fredrick
Published: October 2024

The study examines the correlation between energy consumption and the journey towards achieving net zero emissions in G7 nations spanning from 2002 to 2022. The study reveals a decline in environmental performance in certain G7 economies, primarily attributed to high carbon emissions from sectors such as manufacturing, construction, and transportation. The United States demonstrates the highest levels of emissions, with Japan and Germany following closely behind. The United Kingdom and Italy exhibit the lowest levels of emissions. The transportation industry plays a substantial role in the generation of carbon emissions. The emissions of methane resulting from energy consumption are also significant. Cross-sectional interdependence is present within the G7 nations, refuting cross-sectional independence. The Pesaran Panel Unit Root Test has confirmed the stationarity in all panels. The analysis using the 2SLS method uncovers a statistically significant and positive impact of emissions from the transport sector on total carbon emissions. The under-identification test and the Cragg-Donald Wald F statistic provide substantial evidence of strong identification, whereas the Sargan test rejects the null hypothesis in the over-identifying constraint test. The study recommends that G7 nations adopt customized policy measures, prioritizing non-fiscal strategies to efficiently mitigate carbon emissions and attain net zero objectives..
JEL classification: O50, Q56, P1
Study on the Synergistic Path of Pollution and Carbon Emissions Reduction in Anhui Province Electricity Industry
Authors: Wu Lei , Zhu Weiwei , Qian Jing , Yang Manyi , Wang Xiaohui
Published: October 2024

Background
As a significant contributor to secondary energy production, the power generation industry has a considerable reliance on fossil fuels. It is a significant source of atmospheric pollutants and greenhouse gas emissions, making it a key target for emission reduction in environmental protection. This study is focused on the power generation industry in Anhui Province, China. The LMDI decomposition model and the LEAP model are employed to establish five emission reduction scenarios, which were used to forecast future trends in carbon dioxide and air pollutant emissions in the power generation sector from 2022 to 2035.
Results
The results indicate that the implementation of comprehensive measures for the promotion of washed coal technology, improvements in thermal power efficiency, and the substitution of clean energy, carbon dioxide, and atmospheric pollutants will reach their peak in 2027, achieving the most optimal emission reduction effects. The analysis of the synergistic emission reduction effects demonstrates that the implementation of comprehensive measures yields the most optimal reduction in carbon dioxide and atmospheric pollutants. Furthermore, the comprehensive scenario exhibits a considerable emission reduction contribution rate.
Conclusions
For the power generation industry in Anhui Province, the simultaneous implementation of three emission reduction measures represents the optimal path for synergistic improvement in pollution reduction and carbon reduction. These measures provide policy recommendations for the power generation industry in other regions seeking to achieve pollution and carbon reduction.
Not-distracting in body sensations: interoceptive focus and somatic symptom in adolescent bipolar disorder patients
Authors: Lv Jialin , Li Juan , Xu Hang , Sun Lin , Zhu Guohui , Wang Weiwen
Published: October 2024

Background
Bipolar disorder (BD) with somatic symptoms is prevalent in adolescent patients. Interoception has an important impact on physical and emotional regulation. However, it is unclear the characteristics of interoception and its relationship to somatization and emotional symptoms in adolescents with BD.
Methods
This study recruited 71 adolescent BD subjects during rehabilitation and 111 age-matched controls. Demographic characteristics, interoception, somatization, depression, and anxiety symptoms were assessed. Mann-Whitney U tests, partial correlation analysis, and multiple linear regression were used to explore the alteration of interoception in BD patients and its association with clinical symptoms.
Results
After adjusting for differential demographic variables, adolescent BD patients scored lower on several dimensions of interoception and higher on somatization and emotional symptoms than controls. Moreover, there were significant differences on the interoceptive dimensions of not-distracting, not-worrying, and trusting between BD patient groups with and without somatization. Correlational analysis revealed that the interoceptive indicators of BD patients were significantly correlated with emotional and somatic symptoms. The dimension of not-distracting was the only interoceptive predictor of somatization symptoms and emotional problems in adolescents with BD, maintaining its predictive stability even after controlling for emotional symptoms. This indicates that the capacity for focused attention is a key interoceptive element affecting the expression of somatic and emotional issues in BD adolescent patients.
Conclusion
Adolescents with BD exhibit deficits in interoception, somatization and emotional issues. The not-distracting aspect of interoception significantly correlates with emotional and somatic symptoms in adolescents with BD, offering insights and targeted strategies for managing psychosomatic symptoms in this demographic.
Abnormal Degree Centrality and Functional Connectivity Associated with Cognitive Impairment in Myotonic Dystrophy Type 1
Authors: Sun Qian , Zhou Haiyan , Huang Pei , Liu Jun , Zhang Jiaxi , Jia Xize , Xue Xiaomeng , Hao Zeqi , He Di
Published: October 2024

Objectives: The present study aimed to examine alterations in voxel-based degree centrality (DC) and functional connectivity (FC), and their relationship with cognitive impairments in individuals with myotonic dystrophy type 1 (DM1).
Methods: Eighteen DM1 patients and eighteen healthy controls (HCs) participated in the study and were assessed using a comprehensive neuropsychological battery. Voxel-wise DC analysis was conducted to identify abnormal neural hubs in DM1 patients. Additionally, FC method was used to assess abnormalities in functional connections among these aberrant hubs. Correlational analyses were also used to identify and explore the relationship between altered DC and FC values and cognitive performance in DM1 patients.
Results: DM1 patients exhibited reduced DC in the bilateral Rolandic operculum, left inferior frontal gyrus (triangular part), right angular gyrus, right median cingulate and paracingulate gyri, and right middle temporal gyrus. Conversely, increased DC was observed in the right fusiform gyrus, right hippocampus and left inferior temporal gyrus. FC analysis revealed that altered connectivity predominantly occurred between the right middle temporal gyrus, right angular gyrus and left inferior frontal gyrus (triangular part). Notably, the DCvaluein the right median cingulate was positively correlated withthe Trail Making Test Part A scores in DM1 patients (r = 0.616, p = 0.005, adjusted p <0.05). No significant correlations were discovered between FC values and neurocognitive performances.
Conclusion: The study demonstrated that abnormalities in degree centrality and functional connectivity may become potential neuroimaging biomarkers for cognitive decline in DM1 patients.
Adaptive burst size-based loss differentiation in OBS networks
Authors: Lee Yonggyu
Published: October 2024

All OBS nodes have fiber delay lines with a fixed basic delay unit, which is used to decide the length of each fiber delay line, calculated under some optimal traﬀic conditions. This means that if traﬀic conditions change, then the fixed basic delay unit and fiber delay lines should be altered. How- ever, because fiber delay lines are fixed hardware components, they are not easily replaced. So, in order to achieve service differentiation under variable traﬀic conditions and fiber delay lines constructed with the fixed basic delay unit value, a new service differentiation algorithm based on a dedicated fiber delay line buffer architecture is proposed. When traﬀic conditions change, the new algorithm dynamically recalculates the threshold value used to decide the length of data bursts. By doing so, although traﬀic conditions change, the algorithm can maintain the service differentiation between classes without re- placing any fiber delay lines. In order to prove the effectiveness of our new algorithm, extensive simulations and numerical analyses were performed. The various results show that the new algorithm successfully guarantee a required loss rate for each class. Also, from the results, it is known that our algorithm eﬀiciently utilizes the fiber delay lines.
Neural network disturbance observer-based anti- saturation backstepping control for hypersonic vehicles
Authors: Dai Pei , Feng DongZhu , Wang Caihui , Zhao Jiaqi , Chen Tianle , Wang Xin
Published: October 2024

This study proposes a radial basis function neural network disturbance observer (RBFNNDO) based anti-saturation backstepping controller for hypersonic vehicles with input saturations and multiple disturbances. Firstly, in response to the problem of “exploding complexity” in backstepping controller, we adopted finite-time tracking differentiators (FTD), which realized higher tracking accuracy and tracking speed than those of the existing methods. Secondly, we developed multivariable neural network disturbance observers to estimate the lumped disturbances involving aerodynamic uncertainties and external disturbances, thereby improving the robustness of the proposed controller. Thirdly, in order to alleviate the input saturation and minimize the duration time, we used an adaptive fixed-time anti-saturation compensator (AFAC). The simulation results have proven that our proposed backstepping controller outperforms other existing methods in terms of control performance and saturation time.
Oral microbiome diversity and composition before and after chemotherapy treatment in pediatric oncology patients
Authors: Immonen Egle , Paulamäki Lauri , Piippo Hannaleena , Nikkilä Atte , Aine Liisa , Peltomäki Timo , Lohi Olli , Parikka Mataleena
Published: October 2024

Objective
This study explored how anticancer treatment affects the oral microbiome in pediatric patients and its link to oral mucositis (OM). It also examined the effects of different mouth rinses (Caphosol vs. saline solution).
Materials and Methods
Saliva samples were collected from patients before and after chemotherapy in a controlled, double-blind, randomized clinical trial. The trial compared Caphosol and saline solution mouth rinses in patients aged 2 to 17.99 years. Bacterial DNA from saliva samples was analyzed using next-generation sequencing to evaluate 16S rRNA.
Results
We analyzed 110 saliva samples from pediatric cancer patients before and after treatment, focusing on those with and without OM. Significant differences were found in bacterial taxa, including the Bacteroidota phylum, which was more abundant in patients without lesions before treatment. Cancer treatment increased the abundance of the Proteobacteria phylum. Distinct microbiome profiles were associated with OM development, including increased pathogenic species like Rothia mucilaginosa and Fusobacterium periodonticum. Differences in microbiota composition were also found between patients using Caphosol and saline solution mouth rinses.
Conclusions
Changes in the oral microbiota before and after anticancer treatment are linked to OM development, offering potential for identifying high-risk patients and promoting protective bacteria.
Trial registration:
The current trial was registered at Clinical trials.gov (ID: NCT02807337, Date: 20-February-2020).
Based on near-infrared spectroscopy and chemometrics to rapidly evaluate the adulteration of Ganoderma lingzhi powder
Authors: Zhang Yanhong , Zhong Lingjiao , Su Hui , Wang Chenye , Wang Pan , Shao Qingsong , Zhang Ailian
Published: October 2024

Ganoderma lingzhi, the dry fruiting bodies of G. lucidum or G. sinensis, is a microbial food of high nutritional and health value. It is expensive but in high demand. In pursuit of higher profits, counterfeit products adulterated with G. lingzhi, such as G. applanatum, have appeared in the market. To identify the authenticity and forecast the degree of adulteration in Ganoderma lingzhi powder rapidly and non-destructively, the combination of near-infrared spectroscopy (NIRS) and chemometrics was used. Partial least squares discriminant analysis (PLS-DA), back propagation neural network (BPNN), support vector machine (SVM), and random forest (RF) were adopted as qualitative identification of G. lingzhi authenticity model methods, and partial least-squares (PLS) was developed as a quantitative prediction of adulteration content. Preprocessing and feature variables selection methods were developed to optimize the model and screen the best model. Among these experimental approaches, PLS-DA + first-order derivatives (D1), SVM + D1 + Competitive adaptive reweighted sampling (CARS), RF + standard normal variate transform (SNV) and BPNN + D1 + Uninformative variable elimination (UVE) + CARS achieved 100% classification accuracy. SVM + second-order derivatives (D2) + CARS and BPNN + D2 + CARS identified all adulterated G. lucidum, PLS-DA + D1 + UVE + CARS, RF + D2 + Genetic algorithm (GA), SVM + D2 + GA, and BPNN + D2 + CARS could distinguish all adulterated G. sinensis effectively.
Stator Currents and Rotor Equivalent Sources Modelling and Analysis of Dfig in Wind Energy Systems
Authors: srav barri
Published: October 2024

The Doubly-Fed Acceptance Generator (DFIG) plays a critical part in present day wind vitality frameworks due to its adaptability in variable-speed applications, tall proficiency, and capability to work beneath fluctuating wind conditions. In the show situation, DFIGs are broadly utilized in wind turbines since they permit autonomous control of dynamic and receptive control, upgrading framework steadiness and vitality productivity. The variable-speed operation empowered by the rotor-side converter too makes a difference moderate mechanical stresses on the turbine, progressing generally framework reliability. The Proportional-Integral (PI) control methodology for DFIGs, advertising a few focal points such as effortlessness, ease of usage, and vigorous execution beneath different working conditions. By controlling both stator and rotor-side voltages and streams, PI controllers proficiently oversee dynamic and receptive control stream, guaranteeing smooth network integration. The PI control approach gives steady energetic reaction, diminished motions, and improved framework execution, making it a well-known choice for both grid-connected and standalone DFIG applications. This investigates rotor and stator current flow for torque and control control, giving experiences into how successful control can optimize control yield and make strides framework steadiness. By considering these cases, the proposed control strategy illustrates made strides execution in controlling electrical amounts, accomplishing craved control stream, and minimizing unsettling influences in real-world operational scenarios.
Clinical outcomes with all-oral regimens in patients of drug-resistant tuberculosis: A prospective study in a tertiary hospital in North India
Authors: Kumar Vijay , Sri.Bhar G.S. , Bhatia Mohit , Chakrabarti Sankha Shubhra , Kaur Upinder , Mishra JK
Published: October 2024

Objective:
The main aim of this study is to provide therapeutic outcomes with bedaquiline-based all-oral regimens of drug-resistant tuberculosis (DR-TB).
Methods: A prospective observational study was conducted from August 2022 to March 2024 and patients of DR-TB on all-oral regimens were enrolled.
Results:
Seventy-three patients from long-oral (LO) regimens and 15 from the short-oral (SO) regimen were followed up at 6 months. Sixty-two (84.9 %) patients of LO, and 11 (67.9 %) patients of SO regimen achieved microbiologic improvement in one sample. Clinical improvement occurred in the majority. Forty-five (60.8 %) patients of LO and six (35.3%) patients of SO regimen required treatment modification, and the major reason was intolerability due to peripheral neuropathy. Skin pigmentation (43.8%), anemia (35.6%), and thrombocytopenia (26%) were other common adverse events (AEs), and optic neuritis occurred in two patients in the LO regimen. Hepatitis and thrombocytopenia occurred commonly with regimens combining bedaquiline and delamanid. Linezolid dose was reduced in 45.2% and the drug was replaced in 17.8%, commonly by pyrazinamide and delamanid.
Conclusion:
Interim microbiological outcomes with all-oral regimens of DR-TB were favorable. Extended monitoring is needed to assess the sustenance of treatment effect. AEs such as peripheral neuropathy are a major challenge and emphasize the need for newer regimens with better safety profiles.
Ferroptosis exacerbates myocardial ischemia-reperfusion injury via worsening oxidative stress and inflammatory responses: the role of Ferritin/SLC7A11/GPX-4 signaling pathway
Authors: Wang Lihong , Li Dongfang , Jia Zhi
Published: October 2024

Ferroptosis is closely linked to pathological processes in cardiomyocytes. However, the role of ferroptosis in myocardial ischemia-reperfusion injury (MI/RI) and its underlying mechanisms are unknown. Transitional accumulation of iron ions, as well as oxidative stress and lipid peroxidation production were found in the MI/RI model. These were significantly inhibited by an iron death inhibitor. In MI/RI-induced tissue damage and inflammatory responses, inhibition of ferroptosis reduced cardiac infarct area and resisted inflammation. Mechanistic investigations show that inhibition of ferroptosis via the Ferritin/SLC7A11/GPX-4 axis can target MI/RI mitigation, highlighting the potential of inhibiting ferroptosis as a novel strategy for therapeutic of MI/RI.
Adaptive Behavior-Based Ransomware Detection via Dynamic Flow Signatures
Authors: Loco Pedro , Alonso Sebastian , Hartmann George , Whitmore James , McLaughlin Edward
Published: October 2024

Ransomware continues to pose a significant threat to both individuals and organizations, evolving with sophisticated tactics that bypass traditional detection methods. The introduction of Adaptive Behavior-Based Ransomware Detection (ABRD) presents a dynamic solution capable of identifying ransomware through real-time behavioral analysis, bypassing the limitations of signature-based techniques. ABRD operates through the extraction of flow signatures, capturing operational characteristics of ransomware attacks, which allows for the detection of novel and zero-day variants without relying on predefined signatures. The system utilizes machine learning models to analyze these behavioral patterns, continuously adapting to emerging threats and ensuring high detection accuracy. Experimental evaluations demonstrated ABRD's effectiveness in handling encrypted communications, minimizing false positives, and scaling efficiently across network environments. Its ability to detect ransomware in real-time, combined with adaptive learning capabilities, positions ABRD as a powerful tool for automating cybersecurity defenses and addressing the challenges posed by the constantly evolving landscape of ransomware attacks.
Приманка строгости: математическая традиция в эпоху научной революции раннего Нового времени
Authors: И.С. Дмитриев
Published: October 2024

Раздел книги посвящен рассмотрению ряда важных аспектов становления математической традиции в натурфилософии периода научной революции раннего Нового времени. Показано, что в этот период сформировалось критическое отношение к свойственной аристотелизму маргинализации математики по причине ее иррелевантности к поискам причинных объяснений природных явлений, что способствовало постепенному освобождению так называемых смешанных математических наук (mathematicae mixtae или mediae [СМН]) от ограничений аристотелевой эпистемологии. В ситуации научной революции, точнее, ее натурфилософского этапа (XVI–XVII вв.), имела место не математизация картины мира (или натуральной философии), — математика продолжала применяться там, где она использовалась и ранее, т.е. в СМН (хотя со временем математический аппарат обогащался новыми методами), — а скорее физикализация СМН, благодаря чему они стали частью натурфилософского знания. Вместе с тем, в ряде случаев использование математики при изучении тех или иных явлений имело селективный характер. В качестве характерного примера рассмотрена крайне негативная реакция математиков Общества Иисуса (иезуитов) на становление и распространение концепции бесконечно малых величин и «метода неделимых» Б. Кавальери, которые стали основой дифференциального и интегрального исчислений.

This book section is devoted to the consideration of a number of important aspects of the formation of the mathematical tradition in natural philosophy during the Scientific Revolution of the early modern period. It is shown that during this period a critical attitude to the marginalization of mathematics inherent in Aristotelianism due to its irrelevance to the search for causal explanations of natural phenomena was formed, which contributed to the gradual liberation of the so-called mixed mathematical sciences (mathematicae mixtae or mediae [MMS]) from the limitations of Aristotelian epistemology. In the situation of the scientific revolution, more precisely, its natural philosophical stage (16th– 17th cc.), there was not a mathematization of the world picture (or natural philosophy) — mathematics continued to be used where it had been used before, i.e. in the MMS (although over time the mathematical apparatus was enriched with new methods) — but rather a physicalization of the MMS, thanks to which they became part of natural philosophical knowledge. At the same time, in a number of cases, the use of mathematics in the study of certain phenomena was selective. As a typical example, the section considers the extremely negative reaction of the mathematicians of the Society of Jesus (Jesuits) to the formation and spread of the concept of infinitesimals and the “method of indivisibles” of B. Cavalieri, which became the basis of differential and integral calculus.
Effects of Fruit Ripeness and Storage Temperature on the Deterioration Rate of Fresh-cut Peach and Nectarine Slices
Authors: Gorny James R. , Hess-Pierce Betty , Kader Adel A.
Published: October 2024

The effects of fruit ripeness and postcutting storage temperature on the deterioration rate of fresh-cut `Flavorcrest' peaches and `Zee Grand' nectarines [Prunus persica (L.) Batsch] were investigated. Based on visual quality, peach and nectarine slices from mature-green fruit (>40-53 N flesh firmness) had the longest shelf-life (8 days at 0 °C for peaches and 8 d at 0, 5, or 10 °C for nectarines). However, slices from mature-green peaches and nectarines as well as partially ripe peaches (>27-40 N flesh firmness) failed to soften to acceptable eating quality when held at 0 or 5 °C. Slices from overripe peach and nectarine fruit (0-13 N flesh firmness) were organoleptically acceptable at the time of cutting, but based on visual quality had a shelf-life of only 2 days or less (peach) or 3 to 6 days (nectarine) when stored at 0, 5, or 10 °C. The optimal ripeness for preparing fresh-cut peach slices was the ripe (>13-27 N flesh firmness) stage and these slices at 0 °C and 90% to 95% relative humidity (RH) had a shelf-life of 6 days, while retaining good eating quality. The optimal ripeness for preparing fresh-cut nectarine slices was the partially ripe (>27-49 N) or ripe (>13-27 N flesh firmness) stages and these slices at 0 °C and 90% to 95% RH had a shelf-life of 8 days, while retaining good eating quality.
PANCREATIC INSULINOMA, FROM DIAGNOSIS TO TREATMENT : RETROSPECTIVE STUDY IN THE GENERAL SURGERY DEPARTMENT OF CHU MOHAMMED VI, MARRAKECH
Authors:   Laayoune Faculty of Medicine and Pharmacy., Riyad A. , Rabbani K. ,   Department of Visceral Surgery, Arrazi Hospital, CHU Mohammed VI. Morpho-Sciences Laboratory. Faculty of Medicine and Pharmacy, Marrakech.
Published: October 2024

Insulinomais a rare tumor of the pancreasbelonging to the group of functional neuroendocrine tumors, and isitsmostcommonform. It affects 1 to 4 individuals per 1 million of the general population. Neuroglycopenic manifestations are the most dominant, makingdiagnosisoftenlate, which has benefitedfrom the development of variousmorphologicalmeans of exploration. The management of thesetumorsincludes conservative treatment of hypoglycemiainduced by insulinhypersecretion, non-invasive procedures and surgery, whichremains the cornerstone of radical treatment. Our workis a retrospectivestudybased on a review of the records of patients managed for pancreaticinsulinoma in the generalsurgerydepartment of CHU Mohammed VI in Marrakech, over a period of 06 years (fromJanuary 2017 to December 2022), itaims to shed light on the epidemiological, clinical, paraclinical and therapeuticfeatures of insulinomas.
A CASE OF METASTATIC INTRACARDIAC RHABDOMYOSARCOMA
Authors:   Cardiology Center, Department of Non Invasive Imaging, Mohamed V Military Hospital of Rabat., Ouaouicha H. , Lokman H. ,   Cardiology Center, Department of Non Invasive Imaging, Mohamed V Military Hospital of Rabat., Jaafari M. ,   Cardiology Center, Department of Non Invasive Imaging, Mohamed V Military Hospital of Rabat., Ahchouch S. ,   Cardiology Center, Department of Non Invasive Imaging, Mohamed V Military Hospital of Rabat., Asfalou I. ,   Cardiology Center, Department of Non Invasive Imaging, Mohamed V Military Hospital of Rabat., Benyass A. ,   Cardiology Center, Department of Non Invasive Imaging, Mohamed V Military Hospital of Rabat.
Published: October 2024

Intracardiac metastasis of rhabdomyosarcoma (RMS) is a rare occurrence, with only a few cases reported in the literature. RMS is a malignant tumor of skeletal muscle origin, primarily affects children and young adults and rarely adults. It is characterized by an aggressive spread, often metastasizing to the lungs, bone marrow, and lymph nodes. However, cardiac involvement is uncommon and typically presents late in the disease course, complicating management and worsening prognosis. This article explores a rare case of intracardiac metastasis of RMS, discussing the clinical presentation, diagnostic challenges, treatment modalities, and prognosis. We also review relevant literature to provide a comprehensive understanding of this rare phenomenon.
Impact of support structure on surface roughness and mechanical properties of PLA 3D printed parts by FDM
Authors: Antar Intissar , Zarbane Khalid , El Oumami Mohamed , Beidouri Zitouni
Published: October 2024

This study investigates the effect of support infill angle and its density, transverse at 90°, inclined at 45°, axial direction at 0° and crossed filament by (0°/90°), (45°/-45°) and (0°/45°) on surface quality and mechanical properties using three different strategies. The surface roughness and flexural properties of the specimens are analysed and compared as well as the material waste and printing time. According to results of this study, the variations in the support infill angle resulted in diverse flexural strength and surface quality.
Latest Trends In 3D Printed Microfluidics
Authors: Haouari Khadija Bekkay , Ouardouz Mustapha
Published: October 2024

Over the last decade, there has been a large interest in the use of 3D printing to manufacture microfluidic devices, since it has the ability to circumvent traditional fabrication techniques limitations. These include being unable to really make complex three-dimensional architectures, expensive and time-consuming processes to change device designs, and difficulty transitioning from prototyping to mass production. In this literature review, we will look at the current trends in 3D printed microfluidics, as well as recent advances and new developments in fabrication techniques, materials, and applications. Integration of 3D printing in microfluidics research has helped in the rapid prototyping of fluidic channels and structures with high complexity at an effective cost. Applications of 3D printed microfluidics are described in the areas of healthcare, diagnostics, chemical synthesis, and biotechnology. This paper also delineates the challenges and future prospects of 3D printed microfluidics, giving insight into potential research directions and technological developments.
Moisture-Responsive Cellulose For 4D Printing
Authors: AL NAHARI Bassam , ZARBANE Khalid , BEIDOURI Zitouni
Published: October 2024

Particularly focusing on 4D printing, a technology enabling objects to transform over time. We explore smart materials, emphasizing moisture-responsive variants crucial for 4D printing. Notably, cellulose emerges as key, offering renewable and sustainable bio-based filaments. We detail the meticulous preparation of cellulose from sugarcane bagasse, obtaining high-purity fibers essential for 4D printing. These filaments exhibit versatile stiffness and moisture responsiveness, crucial for hygromorphic structures. Our proposed method integrates a codesign approach tailored for 4D printing, utilizing fused filament fabrication and cellulose-filled filaments. Through this investigation, we uncover cellulose’s potential in sensor technology and additive manufacturing, marking significant progress in responsive materials and 4D printing.
İşletmeler Bağlamında Metaverse: Swot Analizi İle Durum Değerlendirmesi
Authors: Özcan Gamze
Published: October 2024

Dijital dünya giderek evrimleşmekte ve bu değişimin merkezinde Metaverse bulunmaktadır. Yaklaşık otuz yıl önce Neal Stephenson’un Snow Crash adlı bilim kurgu kitabında ilk kez ortaya atılan Metaverse kavramı, fiziksel gerçekliği dijital sanallıkla birleştiren sürekli, kalıcı ve çok kullanıcılı bir ortam olan gerçeklik sonrası bir evrendir. İşletmeler açısından sanal dünyada yeni pazarlama, satış ve müşteri etkileşimi fırsatları sunmakta, sınırların ortadan kaldırılmasıyla küresel müşteri kitlesine ulaşmayı daha kolay hâle getirmektedir. Metaverse, işletmeler için büyük fırsatlar sunan dinamik bir dijital ekosistem olmakla birlikte aynı zamanda bazı zorlukları da beraberinde getirmektedir. Dolayısıyla yavaş yavaş kendi ekonomisini yaratan Metaverse teknolojilerinin işletmeler üzerindeki etkisini anlamanın ve bu yöndeki tartışmaların literatürdeki karşılıklarını takip etmenin değerli olduğu düşünülmektedir. İşletmelerin, bu yeni dijital dünyanın potansiyelini anlamaları, doğru stratejileri geliştirmeleri ve bu dinamik değişime adapte olabilmeleri için SWOT analizi gibi güçlü bir araca başvurulması gerektiği düşünülmektedir. SWOT analizi işletmelerin etkili stratejiler geliştirmelerine yardımcı olurken, güçlü yönlerini kullanarak zayıf yönleriyle başa çıkmalarını sağlamaktadır. Bu çalışma, nitel veri toplama yöntemi olan doküman incelemesi yoluyla gerçekleştirilmiştir. Bu bağlamda, dokümanlardaki bilgilerden ve yorumlardan faydalanılmış ve doküman incelemesi sonuçları SWOT analizi çerçevesinde sunulmuştur. Son olarak işletmelere ve araştırmacılara konuyla ilgili önerilerde bulunulmuştur. Bu evrenin SWOT analizi yöntemiyle değerlendirilmesinin spesifik olarak işletmeler bağlamında yapılması ile çalışmanın literatüre katkı sağlayacağı düşünülmektedir.
Şiirde Tip Ayrımı: “Sühâ ve Pervin”
Authors: Sağıroğlu Birsel
Published: October 2024

Bu çalışmada, Tevfik Fikret’in 1897’de kaleme aldığı “Sühâ ve Pervin” şiiri, Carl Gustav Jung’un bireysel mizaçları dikkate alarak sorunsallaştırdığı ve iki temel sınıflandırmada ele aldığı “tip ayrım” ından yola çıkılarak çözümlenmiştir. Jung’a göre insan psikolojisinde iki tip ve belli yönde edimde bulunmasına/tepki vermesine neden olan “tutum”lar vardır. Bunlardan ilki, kendine dolayısıyla iç “ben”ine diğeri ise “nesne”ye yönelir. Birinin veya diğerinin üstünlüğü tipi belirler ve saf bir tip mümkün değildir. Bununla birlikte her tip, bilincin (birincil işlev) ya da bilinçdışının (ikincil işlev) baskın konumu nedeniyle düşünmeye ya da hissetmeye yönelik farklı tutumlar geliştirebilir. Bunlar aynı zamanda arkaik izler taşıyarak Doğulu-Batılı imgeleri görünür kılar ve iç dengeyi sağlamak için tek taraflılığı telafi etmeye çabalar. “Sühâ ve Pervin”, Jung’un tip sınıflandırılmasını destekleyecek çok sayıda malzeme içerir. Bu çalışmanın amacı, Jungcu bağlamda şiiri iki tip üzerinden anlamlandırmak ve “ben-kendilik”, “birincil-ikincil işlev”, “zıddına dönüşme”, “Doğulu-Batılı imge” kavramları aracılığıyla şiire özgün bir bakış açısı kazandırabilmektir. Şiirde, Sühâ iç dünyasına yönelirken Pervin “nesne/ler”e yönelerek kendinden uzaklaşır. Dolayısıyla ilkinde özne, diğerinde nesne değerlidir. Beri yandan Sühâ, kamusal alanı yorumlarken “Doğulu” bir tavır sergiler. İçe bakış, bunun sonucunda açığa çıkan tefekkür ve çocuksu hâl bu tavırda belirgindir. Pervin ise kendi “ben”ine dolayısıyla bilincine yaslanır, kamusal alandan ve onun nesnelliğinden güç alır ve kolektif imgeden ayrılır. Pervin’in rasyonelliğe yakın hâlleri “Batılı” tavrı görünür kılar. Bununla birlikte iki figür iç dengeyi sağlayacak zıddına dönüşme (enantiodromia) fikrinden bütünüyle uzaklaşarak sabit bir mizaçta donar/kımıltısızlaşır.