bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring Pediococcus sp. M21F004 for Biocontrol of Bacterial and Fungal Phytopathogens
Authors: Nguyen Van Thi , Kwon Yong Min , Park Ae Ran , Yu Nan Hee , Choi Grace , Kim Jin-Cheol
Published: November 2024

This study explores the biocontrol potential of Pediococcus sp. M21F004, a lactic acid bacteria (LAB) isolated from marine environments, against several bacterial and fungal phytopathogens. Out of 50 marine bacterial isolates, Pediococcus sp. M21F004 was selected for its exceptional antimicrobial activity. The strain, isolated from the intestine of a starry flounder, was identified as Pediococcus sp. Gas chromatography–mass spectrometry (GC-MS) analysis revealed that oleic acid (OA) is a key antimicrobial compound produced by Pediococcus sp. M21F004. In vitro assays showed that the culture broth (CB) of Pediococcus sp. M21F004, as well as OA, exhibited significant inhibitory effects against pathogens such as Fusarium oxysporum, Clarireedia homoeocarpa, and Pectobacterium carotovorum subsp. carotovorum. In vivo tests on cucumber Fusarium wilt, creeping bentgrass dollar spot, tomato bacterial wilt, and kimchi cabbage soft rot further demonstrated the strain’s efficacy in reducing disease severity. Moreover, OA had the highest control value of 74% against tomato bacterial wilt, followed by 64.1% against cucumber fusarium wilt, 42.5% against kimchi cabbage soft rot, and 16.5% against creeping bentgrass dollar spot. These findings suggest that Pediococcus sp. M21F004 and its metabolite OA offer promising alternatives to chemical pesticides, contributing to sustainable plant disease management by promoting resistance induction and providing an eco-friendly approach to agriculture.
Correction: Hirasawa et al. Comparative Analysis of Muscle Activity and Circulatory Dynamics: A Crossover Study Using Leg Exercise Apparatus and Ergometer. Medicina 2024, 60, 1260
Authors: Hirasawa Nobuhiro , Shimizu Yukiyo , Haginoya Ayumu , Soma Yuichiro , Watanabe Gaku , Takehara Kei , Tokeji Kayo , Mataki Yuki , Ishii Ryota , Hada Yasushi
Published: November 2024

In the original publication [...]
Five-Year Trends in Low-Density Lipoprotein Cholesterol Management in a Primary Healthcare Centre in Kaunas
Authors: Urbonas Gediminas , Šileikienė Lolita , Valius Leonas , Grigalė Evelina , Kaupas Vilius , Juška Tautvydas , Vėbraitė Gabrielė , Grabauskytė Ingrida
Published: November 2024

Background and Objectives: Low-density lipoprotein cholesterol (LDL-C) is a marker of cardiovascular risk and its management. This study evaluated LDL-C control trends in patients treated at a primary healthcare center in Lithuania. Materials and Methods: Five-year (2019–2023) data on patients aged 40 years or older diagnosed with dyslipidemia were extracted from a real-world data and analytics platform, TriNetX. Patients were grouped into three groups: patients with dyslipidemia only (control group), patients with dyslipidemia and diabetes, and patients with dyslipidemia and cardiovascular disease (CVD). The following LDL-C goals were used for analysis: <1.4 mmol/L (a goal for very-high-risk patients in primary or secondary prevention), <1.8 mmol/L (a goal for high-risk patients), and <3.0 mmol/L (a goal for low-risk patients). Results: There were 18,646 patients with dyslipidemia. Of them, 8.9% of patients had diabetes, and 3.1% of patients had CVD. The median LDL-C concentration was significantly lower in patients with diabetes (2.82 mmol/L, p < 0.05) and in patients with CVD (2.45 mmol/L, p < 0.05) than in the control group (3.35 mmol/L). A trend of decreasing median LDL-C over the years was observed in all groups, with the lowest median values in 2023. The proportion of patients with LDL-C levels < 3 mmol/L increased from 32.0% in 2019 to 41.5% in 2023. The proportion of diabetic patients achieving LDL-C < 1.8 mmol/L increased from 7.4% to 25.9%, and those achieving LDL-C < 1.4 mmol/L increased from 3.1% to 10.6%. The proportion of patients with CVD achieving LDL-C < 1.8 mmol/L increased from 14.2% to 36.6%, and those achieving LDL-C < 1.4 mmol/L increased from 3.0% to 14.0%. Conclusions: Trends in the control of LDL-C levels are positive over 5 years, but a significant proportion of patients still did not reach the recommended target levels.
CFD Analysis of Particle Dynamics in Accelerated Toroidal Systems for Enhanced PIVG Performance
Authors: Elaswad Ramy , El-Sheimy Naser , Mohamad Abdulmajeed
Published: November 2024

This study investigates the movements of particles in an accelerated toroidal flow channel filled with water, with specific applications for a particle imaging velocimetry gyroscope (PIVG). We used computational fluid dynamics (CFD) to simulate particle behavior under different angular accelerations. These angular accelerations were 4 rad/s2, 6 rad/s2, and 8 rad/s2 for particles densities of 1100 kg/m3, 1050 kg/m3, and 980 kg/m3. An examination was performed on the particles’ concentration distribution, velocity profiles, and displacement patterns with respect to the toroidal geometry, which had a volume fraction of 1.5% and was sized at 50 microns. Our results show that particle density significantly affects behavior and displacement within the toroidal flow, with heavier particles (1100 kg/m3) settling more quickly and concentrating near the lower z values over time, while lighter particles (980 kg/m3) maintain a more uniform distribution. This understanding is crucial for optimizing PIVG accuracy and reliability.
Advancements in Materials for 3D-Printed Microneedle Arrays: Enhancing Performance and Biocompatibility
Authors: Razzaghi Mahmood , Alexander Ninan Joel , Akbari Mohsen
Published: November 2024

The rapid advancement of 3D printing technology has revolutionized the fabrication of microneedle arrays (MNAs), which hold great promise in biomedical applications such as drug delivery, diagnostics, and therapeutic interventions. This review uniquely explores advanced materials used in the production of 3D-printed MNAs, including photopolymer resins, biocompatible materials, and composite resins, designed to improve mechanical properties, biocompatibility, and functional performance. Additionally, it introduces emerging trends such as 4D printing for programmable MNAs. By analyzing recent innovations, this review identifies critical challenges and proposes future directions to advance the field of 3D-printed MNAs. Unlike previous reviews, this paper emphasizes the integration of innovative materials with advanced 3D printing techniques to enhance both the performance and sustainability of MNAs.
Fabrication of an Integrated, Flexible, Wireless Pressure Sensor Array for the Monitoring of Ventricular Pressure
Authors: Hernández-Sebastián Natiely , Diaz-Alonso Daniela , Barrientos-García Bernardino , Renero-Carrillo Francisco Javier , Calleja-Arriaga Wilfrido
Published: November 2024

This work presents the design, fabrication, and rigorous validation of a flexible, wireless, capacitive pressure sensor for the full-range continuous monitoring of ventricular pressure. The proposed system consists of an implantable set and an external readout device; both modules were designed to form an RCL resonant circuit for passive, wireless pressure sensing and signal retrieving. Using surface micromachining and flexible electronics techniques, a two-variable capacitor array and a dual-layer planar coil were integrated into a flexible ergonomic substrate, avoiding hybrid-like connections in the implantable set. The proposed arrangement (capacitor array and dual-layer coil) allows us to optimize the operation pressure range and sensing distance. The use of polyimide as both the flexible substrate and the passivation material is a key feature, ensuring a biocompatible, implantable set that is mechanically flexible and can be folded to a compact size to achieve minimally invasive implantation. An external readout device has also been developed using a discrete printed circuit board (PCB) approach to support pressure measurements. The pressure responsivity of the sensor was validated to the laboratory level using a controlled pressure chamber. The results obtained show that the capacitance value of the sensor changed from 5.68 pF to 33.26 pF as the pressure varied from 0 to 300 mmHg. Correspondingly, the resonance frequency of the implantable set shifted from 12.75 MHz to 5.27 MHz. The sensitivity of the capacitive sensor was approximately 0.58 pF/mmHg and the typical response time was 220 ms. The wireless system performance was evaluated in both air and synthetic biological tissue using a Maxwell–Wien bridge circuit. The results showed a sensing distance longer than 3.5 cm, even under moderate misalignment conditions (up to 1.5 cm). The output voltage was successfully measured, ranging from 502.54 mV to 538.29 mV, throughout the full pressure range, with a measurement error of ±2.2 mV.
Etching Chemistry Process Optimization of Ethylene Diluted with Helium (C2H4/He) in Interconnect Integration
Authors: Lee Hwa-Rim , Jung Eun-Su , Yoo Jin-Uk , Choi Tae-Min , Pyo Sung-Gyu
Published: November 2024

This study explores the effects of different passivation gases on the properties of polymers formed on aluminum (Al) sidewalls during the etching process in Al-based interconnect structures. The research compares the use of nitrogen (N2) and ethylene diluted with helium (C2H4/He) as passivation gases, focusing on the resulting polymer’s composition, thickness, and strength, as well as the levels of residual chlorine post-etch. The findings reveal that using C2H4 leads to the formation of a thinner, weaker polymer with lower chlorine residue compared to the thicker, stronger polymer formed with N2. Elemental analysis further highlights significant differences in carbon and oxygen content, with C2H4-based polymers exhibiting lower carbon and higher oxygen levels. These results underscore the critical impact of passivation gas choice on the etching process and the integrity of Al-based interconnects, offering valuable insights for optimizing metal etching processes in semiconductor manufacturing.
Engineering Wettability Transitions on Laser-Textured Shark Skin-Inspired Surfaces via Chemical Post-Processing Techniques
Authors: Lori Zoudani Elham , Nguyen Nam-Trung , Kashaninejad Navid
Published: November 2024

Surface wettability, the interaction between a liquid droplet and the surface it contacts, plays a key role in influencing droplet behavior and flow dynamics. There is a growing interest in designing surfaces with tailored wetting properties across diverse applications. Advanced fabrication techniques that create surfaces with unique wettability offer significant innovation potential. This study investigates the wettability transition of laser-textured anisotropic surfaces featuring shark skin-inspired microstructures using four post-processing methods: spray coating, isopropyl alcohol (IPA) treatment, silicone oil treatment, and silanization. The impact of each method on surface wettability was assessed through water contact angle measurements, scanning electron microscopy (SEM), and laser scanning microscopy. The results show a transition from superhydrophilic behavior on untreated laser-textured surfaces to various (super)hydrophobic states following surface treatment. Chemical treatments produced different levels of hydrophobicity and anisotropy, with silanization achieving the highest hydrophobicity and long-term stability, persisting for one year post-treatment. This enhancement is attributed to the low surface energy and chemical properties of silane compounds, which reduce surface tension and increase water repellence. In conclusion, this study demonstrates that post-processing techniques can effectively tailor surface wettability, enabling a wide range of wetting properties with significant implications for practical applications.
Recovery of Metals from Titanium Ore Using Solvent Extraction Process: Part 1—Transition Metals
Authors: Rotich Nelson Kiprono , Herdzik-Koniecko Irena , Smolinski Tomasz , Kalbarczyk Paweł , Sudlitz Marcin , Rogowski Marcin , Stosnach Hagen , Chmielewski Andrzej G.
Published: November 2024

Solvent extraction of metals from Ti ore was investigated with a view of enhancing extraction yields by changing the concentration of the ligands, the rate of mixing, the pH, and the temperature of the solution. Norwegian Ti ore was leached with 5M HNO3 alongside 10% ascorbic acid to obtain a pregnant solution containing transition metals and some rare earth elements (REEs). Part Two of the study will address the recovery of the REEs in the ore. The elemental analysis of solid and aqueous samples was done by two models of total reflection X-ray fluorescence spectrometers (S2 PICOFOX, Bruker Corporation, Berlin, Germany; and T-STAR, Bruker Corporation, Berlin, Germany). The same analysis was repeated using an inductively coupled plasma-mass spectrometer (Perkin Elmer Sciex ELAN DRC II, Perkin Elmer, Waltham, MA, USA). The extraction process and parameters were examined by ICP-MS. The extraction efficiencies were studied under different conditions through the use of various concentrations of ligands at different pHs, temperatures, and mixing rates of the solution. At pH 1.0, 22.5 °C, and a mixing rate of 1400 rpm, the selectivity of 150 g/L trioctyl methyl ammonium chloride (Aliquat 336) was 99% Ti4+, 94% V4⁺, and 82% Hf4+, while 99% of Co2⁺ was recovered at pH 0.8. The extraction efficiency of triethyl phosphate (10% TEP) was 58% Cu2⁺, 68% Mn2⁺, and 63% V4⁺ at 55 °C, 1400 rpm, and without a pH change. Tributyl phosphate (10% TBP) was able to retrieve 87% Cu2⁺ and 78% Zn2⁺ at pH 1.3, 1400 rpm, and 22.5 °C, and 80% Ti4+ at pH 1.2. A 10% solution of 2,4,6-tris (allyloxy)-1,3,5-triazine (TAOT) demonstrated 61% Mn2⁺ and 56% Hf4+ extraction at pH 1.3, 22.5 °C, and 1400 rpm. Under the same conditions, 10% methyl salicylate (MS) was able to recover 56% Hf4+ at pH 1.3. Using 1400 rpm, di (2-ethylhexyl) phosphoric acid (10% D2EHPA) was found to selectively extract 87% Hf4+ at 22.5 °C without a pH change, and around 99% Co2⁺, Ti4+, and Fe2⁺ at pH 1.3. This study provides valuable insights into optimizing solvent extraction conditions for transition metals’ recovery and serves as a precursor to future research on the extraction of REEs from Ti ores. This process is relevant from the environmental and economic perspectives since it provides the best approach to recycling metals to reduce the rate of raw ore mining.
Mineral Deposition on the Rough Walls of a Fracture
Authors: Rodrigues Nathann Teixeira , Carrasco Ismael S. S. , Voller Vaughan R. , Aarão Reis Fábio D. A.
Published: November 2024

Modeling carbonate growth in fractures and pores is important for understanding carbon sequestration in the environment or when supersaturated solutions are injected into rocks. Here, we study the simple but nontrivial problem of calcite growth on fractures with rough walls of the same mineral using kinetic Monte Carlo simulations of attachment and detachment of molecules and scaling approaches. First, we consider wedge-shaped fracture walls whose upper terraces are in the same low-energy planes and show that the valleys are slowly filled by the propagation of parallel monolayer steps in the wedge sides. The growth ceases when the walls reach these low-energy configurations so that a gap between the walls may not be filled. Second, we consider fracture walls with equally separated monolayer steps (vicinal surfaces with roughness below 1 nm) and show that growth by step propagation will eventually clog the fracture gap. In both cases, scaling approaches predict the times to attain the final configurations as a function of the initial geometry and the step-propagation velocity, which is set by the saturation index. The same reasoning applied to a random wall geometry shows that step propagation leads to lateral filling of surface valleys until the wall reaches the low-energy crystalline plane that has the smallest initial density of molecules. Thus, the final configurations of the fracture walls are much more sensitive to the crystallography than to the roughness or the local curvature. The framework developed here may be used to determine those configurations, the times to reach them, and the mass of deposited mineral. Effects of transport limitations are discussed when the fracture gap is significantly narrowed.
Investigation of the Testing Method of Softening–Melting Properties of Iron-Bearing Materials
Authors: Fan Kai , Jiang Xin , Zhang Xin , Wang Qingyu , Gao Qiangjian , Zheng Haiyan , Shen Fengman
Published: November 2024

The softening–melting properties of iron-bearing materials play a crucial role in the reduction process in the lumpy zone in the blast furnace (BF) and affect the height, thickness, and shape of the cohesive zone, as well as gas permeability in the BF. A novel softening–melting method was developed based on actual BF production practices, which consistently matches the reduction index and metallization degree observed in actual BF operations compared to the conventional methods. Under the novel softening–melting testing method, the characteristic temperatures (T40 and TS) increase by about 5 °C and 49 °C, respectively, compared to the conventional method. Additionally, the permeability index (S) of the sinter in the novel method is about 707 kPa·°C lower compared to the conventional method. Clearly, the novel method results in higher softening–melting characteristic temperatures for iron-bearing materials compared to the traditional method, more closely matching actual BF conditions. This approach can provide valuable insights for improving gas permeability and enhancing the reduction process of iron-bearing materials in the BF.
Salinity Effects on the Physicochemical and Mechanical Behavior of Untreated and Lime-Treated Saline Soils
Authors: Benrebouh Imed , Hafhouf Ilyas , Douadi Abdellah , Merdas Abdelghani , Meguellati Abderrahim , Faria Paulina
Published: November 2024

Improving saline soils’ properties by incorporating limes is a practical technique, generally due to cation exchange, pozzolanic reaction, and carbonation. This study explores how soil salinity, measured by electrical conductivity, affects untreated and lime-treated saline soils. An Algerian sebkha soil (from Ain M’lila) with an original high salinity (ECe3 = 23.2 dS.m−1) was used. The same soil was washed to create medium (ECe2 = 8.3 dS.m−1) and low (ECe1 = 2.32 dS.m−1) salinity soil samples. The results of this study indicate that salinity influenced the shape of the particle size distribution curve, particularly in the silt range. Salinity also had a significant effect on carbonate content (CaCO3) and unconfined compressive strength (UCS). For the untreated soil, when salinity decreased, the UCS and CaCO3 content increased. However, when salinity decreased for the treated soil, the UCS increased, while the CaCO3 content decreased. X-ray diffraction (XRD) analysis of untreated soils showed halite (NaCl) disappearance and gypsum (CaSO4 2H2O) reduction with decreasing salinity in ECe1. In treated soil at ECe3, these mineral phases remained constant. While XRD detected no new cementitious phases in treated ECe3 or ECe1 samples, thermogravimetric analysis confirmed the presence of portlandite in both. As Ain M’lila sebkha is a chloride–sulfate soil, the dissolution of the halite and gypsum phases released more Cl− and SO42− ions into the interstitial solution. In a low fraction of clay, these ions obstructed and slowed the pozzolanic reaction in the ECe3 soil. Identifying the season when this type of soil has lower salinity can be beneficial for treatment from a technical, economic, and environmental point of view.
1,2-Oxidative Trifluoromethylation of Olefin with Ag(O2CCF2SO2F) and O2: Synthesis of α-Trifluoromethyl Ketones
Authors: Zhang Shengxue , Xiao Wangchuan , Wu Jingjing , Wu Fanhong , Huang Houjin , Ma Xiaoyu , Shi Yafei , Liu Chao
Published: November 2024

A novel and efficient 1,2-oxidative trifluoromethylation of olefins employing Ag(O2CCF2SO2F) as a trifluoromethyl source is described with O2 as the oxidant, which provides access to a variety of valuable α-trifluoromethyl-substituted ketones. The broad substrate scope, feasibility of large-scale operation, and derivatization reactions of α-trifluoromethyl ketones demonstrate the promising utility of this protocol.
Irisin Attenuates Neuroinflammation Targeting the NLRP3 Inflammasome
Authors: Filannino Francesca Martina , Ruggiero Melania , Panaro Maria Antonietta , Lofrumento Dario Domenico , Trotta Teresa , Benameur Tarek , Cianciulli Antonia , Calvello Rosa , Zoila Federico , Porro Chiara
Published: November 2024

Neuroinflammation is defined as an immune response involving various cell types, particularly microglia, which monitor the neuroimmune axis. Microglia activate in two distinct ways: M1, which is pro-inflammatory and capable of inducing phagocytosis and releasing pro-inflammatory factors, and M2, which has anti-inflammatory properties. Inflammasomes are large protein complexes that form in response to internal danger signals, activating caspase-1 and leading to the release of pro-inflammatory cytokines such as interleukin 1β. Irisin, a peptide primarily released by muscles during exercise, was examined for its effects on BV2 microglial cells in vitro. Even at low concentrations, irisin was observed to influence the NLRP3 inflammasome, showing potential as a neuroprotective and anti-inflammatory agent after stimulation with lipopolysaccharides (LPSs). Irisin helped maintain microglia in their typical physiological state and reduced their migratory capacity. Irisin also increased Arg-1 protein expression, a marker of M2 polarization, while downregulating NLRP3, Pycard, caspase-1, IL-1β, and CD14. The results of this study indicate that irisin may serve as a crucial mediator of neuroprotection, thus representing an innovative tool for the prevention of neurodegenerative diseases.
Application of Nanohydroxyapatite in Medicine—A Narrative Review
Authors: Lubojański Adam , Zakrzewski Wojciech , Samól Kinga , Bieszczad-Czaja Martyna , Świtała Mateusz , Wiglusz Rafał , Watras Adam , Mielan Bartosz , Dobrzyński Maciej
Published: November 2024

This review is an extensive collection of the latest literature describing the current knowledge about nanohydroxyapatite in a comprehensive way. These are hydroxyapatite particles with a size below 100 nm. Due to their size, the surface area to mass ratio of the particles increases. They are widely used in medicine due to their high potential in regenerative medicine, as a carrier of various substances, e.g., in targeted therapy. The aim of this article is to present the biological and physicochemical properties as well as the use of nanohydroxyapatite in modern medicine. Due to the potential of nanohydroxyapatite in medicine, further research is needed.
Liquid CO2-Capture Technologies: A Review
Authors: Zhu Jie , Zhang Haokun , Li Tingting , Deng Tingting , Zou Hao , Li Yongqi , Yang Dingyu
Published: November 2024

Escalating global carbon dioxide (CO2) emissions have significantly exacerbated the climate impact, necessitating imperative advancements in CO2-capture technology. Liquid absorbents have received considerable attention in carbon capture for engineering applications, due to their high flexibility, reliability, and recyclability. Nonetheless, the existing technologies of liquid CO2 capture suffer from various issues that cannot be ignored, such as corrosion, elevated costs, and pronounced secondary pollution. More efforts are required to realize process optimization and novel absorbent innovation. This review presents nanofluids and other novel liquid absorbents such as ionic liquids, amino acids, and phase-change absorbents. The preparation, mechanisms of action, and influencing factors of nanofluid absorbents are discussed in detail to provide researchers with a comprehensive understanding of their potential applications. Further, the challenges (including energy loss, environmental and human health, barriers to application and capture performance, etc.) encountered by these innovative absorbents and techniques are also commented on. This facilitates side-by-side comparisons by researchers.
Hydrogen Production and Li-Ion Battery Performance with MoS2-SiNWs-SWNTs@ZnONPs Nanocomposites
Authors: Machín Abniel , Cotto María C. , Márquez Francisco , Díaz-Sánchez Jesús , Polop Celia , Morant Carmen
Published: November 2024

This study explores the hydrogen generation potential via water-splitting reactions under UV-vis radiation by using a synergistic assembly of ZnO nanoparticles integrated with MoS2, single-walled carbon nanotubes (SWNTs), and crystalline silicon nanowires (SiNWs) to create the MoS2-SiNWs-SWNTs@ZnONPs nanocomposites. A comparative analysis of MoS2 synthesized through chemical and physical exfoliation methods revealed that the chemically exfoliated MoS2 exhibited superior performance, thereby being selected for all subsequent measurements. The nanostructured materials demonstrated exceptional surface characteristics, with specific surface areas exceeding 300 m2 g−1. Notably, the hydrogen production rate achieved by a composite comprising 5% MoS2, 1.7% SiNWs, and 13.3% SWNTs at an 80% ZnONPs base was approximately 3909 µmol h−1g−1 under 500 nm wavelength radiation, marking a significant improvement of over 40-fold relative to pristine ZnONPs. This enhancement underscores the remarkable photocatalytic efficiency of the composites, maintaining high hydrogen production rates above 1500 µmol h−1g−1 even under radiation wavelengths exceeding 600 nm. Furthermore, the potential of these composites for energy storage and conversion applications, specifically within rechargeable lithium-ion batteries, was investigated. Composites, similar to those utilized for hydrogen production but excluding ZnONPs to address its limited theoretical capacity and electrical conductivity, were developed. The focus was on utilizing MoS2, SiNWs, and SWNTs as anode materials for Li-ion batteries. This strategic combination significantly improved the electronic conductivity and mechanical stability of the composite. Specifically, the composite with 56% MoS2, 24% SiNWs, and 20% SWNTs offered remarkable cyclic performance with high specific capacity values, achieving a complete stability of 1000 mA h g−1 after 100 cycles at 1 A g−1. These results illuminate the dual utility of the composites, not only as innovative catalysts for hydrogen production but also as advanced materials for energy storage technologies, showcasing their potential in contributing to sustainable energy solutions.
A Ku-Band Fully Differential Low-Power High-Input P1dB Low-Noise Amplifier
Authors: Lee Sang-Rok , Kim Joon-Hyung , Baek Min-Seok , Kim Choul-Young
Published: November 2024

This paper introduces a Ku-band fully differential low-power high-input 1 dB compression point (P1dB) low-noise amplifier (LNA). A fully differential structure is employed to enhance the input P1dB, common-mode noise rejection, and second harmonic cancellation. The first stage adopts large transistors and is optimized for power consumption and noise figure (NF). The output stage is designed with class AB bias, resulting in improved P1dB, power consumption, and linearity. The proposed two-stage fully differential common-source (CS) LNA was implemented using 65 nm bulk complementary metal oxide semiconductor (CMOS) technology. The fabricated LNA achieved a minimum NF of 2.7 dB at 13.6 GHz. Furthermore, it achieved a maximum gain of 19.92 dB at 12.2 GHz. Additionally, the LNA has an input P1dB of −7.45 dBm and an output power 1 dB compression point (OP1dB) of 10.09 dBm, both measured at 15.6 GHz. The LNA operates with a power consumption of 11 mW at a 1 V supply, and occupies a core size of 0.75 mm × 0.35 mm.
A Comprehensive Review on Iron-Based Sulfate Cathodes for Sodium-Ion Batteries
Authors: Zheng Yalong , Zhang Zhen , Jiang Xinyu , Zhao Yan , Luo Yichao , Wang Yaru , Wang Zhoulu , Zhang Yi , Liu Xiang , Fang Baizeng
Published: November 2024

Sodium-ion batteries (SIBs) are advantageous for large-scale energy storage due to the plentiful and ubiquitous nature of sodium resources, coupled with their lower cost relative to alternative technologies. To expedite the market adoption of SIBs, enhancing the energy density of SIBs is essential. Raising the operational voltage of the SIBs cathode is regarded as an effective strategy for achieving this goal, but it requires stable high-voltage cathode materials. Sodium iron sulfate (NFSO) is considered to be a promising cathode material due to its stable framework, adjustable structure, operational safety, and the high electronegativity of SO4−. This paper reviews the research progress of NFSO, discusses its structure and sodium storage mechanism on this basis, and summarizes the advantages and disadvantages of NFSO cathode materials. This study also evaluates the advancements in enhancing the electrochemical characteristics and structural reliability of SIBs, drawing on both domestic and international research. The findings of this paper offer valuable insights into the engineering and innovation of robust and viable SIB cathodes based on NFSO at ambient temperatures, contributing to their commercial viability.
SVALKA: A Long Noncoding Cis-Natural Antisense RNA That Plays a Role in the Regulation of the Cold Response of Arabidopsis thaliana
Authors: Kiger Nicholas M. , Schroeder Susan J.
Published: November 2024

RNA plays important roles in the regulation of gene expression in response to environmental stimuli. SVALKA, a long noncoding cis-natural antisense RNA, is a key component of regulating the response to cold temperature in Arabidopsis thaliana. There are three mechanisms through which SVALKA fine tunes the transcriptional response to cold temperatures. SVALKA regulates the expression of the CBF1 (C-Repeat Dehydration Binding Factor 1) transcription factor through a collisional transcription mechanism and a dsRNA and DICER mediated mechanism. SVALKA also interacts with Polycomb Repressor Complex 2 to regulate the histone methylation of CBF3. Both CBF1 and CBF3 are key components of the COLD REGULATED (COR) regulon that direct the plant’s response to cold temperature over time, as well as plant drought adaptation, pathogen responses, and growth regulation. The different isoforms of SVALKA and its potential to form dynamic RNA conformations are important features in regulating a complex gene network in concert with several other noncoding RNA. This review will summarize the three mechanisms through which SVALKA participates in gene regulation, describe the ways that dynamic RNA structures support the function of regulatory noncoding RNA, and explore the potential for improving agricultural genetic engineering with a better understanding of the roles of noncoding RNA.
Simulation of Daily Iron Intake by Actual Diet Considering Future Trends in Wheat and Rice Biofortification, Environmental, and Dietary Factors: An Italian Case Study
Authors: Benvenuti Luca , Sette Stefania , De Santis Alberto , Riso Patrizia , Petroni Katia , Crosatti Cristina , Losa Alessia , Martone Deborah , Martini Daniela , Cattivelli Luigi , Ferrari Marika
Published: November 2024

Background and aim: Cereals’ iron content is a major contributor to dietary iron intake in Europe and a potential for biofortification. A simulation of daily iron intake from wheat and rice over the next 20 years will be quantified. Methods: Food items, and energy and iron intake by age classes are estimated using the Italian dietary survey (IV SCAI). Iron intake and adequacy estimation trends were categorized in four scenarios compared to a baseline (basic scenario; only climate change effects): over wheat and rice biofortification effects (scenario 1); over the shift in whole wheat consumption of up to 50% of the total amount of wheat-based foods (scenario 2); over the shift in brown rice consumption up to 100% of the total amount of rice (scenario 3); over the cumulative effects of biofortifications and whole wheat and brown rice consumption (scenario 4). Results: Increasing the iron intake from wheat and rice biofortification and the shift in whole wheat consumption is similar and sufficient to recover the baseline iron depletion effect due to climate change. The shift in brown rice consumption produces a negligible increment in iron intake. The cumulative effects of the corrective actions considered in the scenarios can significantly reduce the iron intake inadequacy, despite not reaching the recommended levels. Conclusions: Corrective actions including biofortification and whole grain consumption are still far from ensuring the full recovery in children and females of fertile age as at-risk groups of iron deficiency. Further actions are needed considering other biofortified food sources, fortified foods, and/or dietary food diversification.
Impact of a Nutrition Knowledge Intervention on Knowledge and Food Behaviour of Women Within a Rural Community
Authors: Mangwane Queen E. M. , Egal Abdulkadir , Oosthuizen Delia
Published: November 2024

Introduction: The influence of women in shaping household dietary habits is undeniable, with their maternal nutritional knowledge significantly impacting the overall well-being of their families. The study objective was to evaluate the impact of maternal nutritional knowledge on household dietary habits, emphasising the improvement in women’s nutrition knowledge and food-related behaviours. Purpose: This study aimed to assess the immediate and long-term effects of a nutrition education intervention on the nutrition knowledge and food-related behaviours of women. Methodology: A quasi-experimental research design was employed to assess the effects of a Nutrition Education Programme (NEP) on female caregivers’ nutrition knowledge and food-related behaviours. This study followed a four-phase approach: baseline survey, programme formulation, implementation and evaluation. Data were collected at various stages of this study using two measurement tools: a Dietary Diversity Questionnaire and a Nutrition Knowledge Questionnaire. Results: Statistical analysis was performed to answer the research questions and to test the null hypotheses at a significance level of 0.05. The intervention positively affected nutrition knowledge, with the mean percentage increasing from 49.1% to 63.7% and reaching 64.4% at follow-up, indicating long-term knowledge retention. The findings of this study suggest a positive shift towards increased consumption of nutrient-rich food groups. There were significant improvements in the food groups’ consumption of the meat group (7.15 ± 2.35), eggs (1 ± 0), dairy (3.76 ± 1.19), cereal (8.78 ± 2.09), legumes (2.86 ± 0.95) and fats and oils (2.12 ± 0.55). Additionally, the variety of food groups consumed significantly improved (p = 0.012) post-intervention, with an increasing trend in the consumption of a variety of food groups (7–9). Recommendation: Tailored nutrition education (NE) programs, in conjunction with addressing socioeconomic barriers positively impact nutritional behaviours, promote healthier food consumption patterns and assist in long-term knowledge retention in disadvantaged communities.
Tryptanthrin Down-Regulates Oncostatin M by Targeting GM-CSF-Mediated PI3K-AKT-NF-κB Axis
Authors: Han Na-Ra , Park Hi-Joon , Ko Seong-Gyu , Moon Phil-Dong
Published: November 2024

Background: Oncostatin M (OSM) is involved in several inflammatory responses. Tryptanthrin (TRYP), as a natural alkaloid, is a bioactive compound derived from indigo plants. Objectives/ Methods: The purpose of this study is to investigate the potential inhibitory activity of TRYP on OSM release from neutrophils using neutrophils-like differentiated (d)HL-60 cells and neutrophils from mouse bone marrow. Results: The results showed that TRYP reduced the production and mRNA expression levels of OSM in the granulocyte–macrophage colony-stimulating factor (GM-CSF)-stimulated neutrophils-like dHL-60 cells. In addition, TRYP decreased the OSM production levels in the GM-CSF-stimulated neutrophils from mouse bone marrow. TRYP inhibited the phosphorylation of phosphatidylinositol 3-kinase (PI3K), AKT, and nuclear factor (NF)-κB in the GM-CSF-stimulated neutrophils-like dHL-60 cells. Conclusions: Therefore, these results reveal for the first time that TRYP inhibits OSM release via the down-regulation of PI3K-AKT-NF-κB axis from neutrophils, presenting its potential as a therapeutic agent for inflammatory responses.
Female Genital Schistosomiasis (FGS) Prevalence and Burden Across Endemic Countries, Timelines, and Age Groups: A Retrospective Study
Authors: Kaur Navneet , Buss Lilianna , Zorn Lauren , Mwansa James , Mutengo Mable M. , Lodh Nilanjan
Published: November 2024

Female Genital Schistosomiasis (FGS) is caused by Schistosoma haematobium, which causes chronic gynecological conditions that lead to substantial morbidity and infertility. This study’s objective is to determine the prevalence and burden of FGS based on the presence of S. haematobium-specific DNA in females across age groups using our previously field-acquired filtered human urine samples from Zambia, Tanzania, and Ghana, collected over multiple years. For Ghana (2013), 39 out of 90 samples were from females, of which 31 (79.5%) were positive and 8 (20.5%) were negative. In Zambia (2016), 80 out of 133 samples were from females, of which 46 (57.5%) tested positive and 34 (42.5%) were negative. For Zambia (2017), 60 out of 110 samples were from females, of which 45 (75%) tested positive and 15 (25%) tested negative. In Tanzania (2018), 70 out of 104 samples were from females, of which 43 (61.4%) tested positive and 27 (38.6%) tested negative. FGS prevalence ranged from 57.5% (Zambia in 2016) to 79.5% (Ghana in 2013) and was found predominantly among the 11–20 years age group. The analytical outcome highlights that FGS is predominant among females in different endemic countries and in the age range of pre-teen to young adult.
Strategies to Enhance Diagnostic Capabilities for the New Drug-Resistant Tuberculosis (DR-TB) Drugs
Authors: Saktiawati Antonia Morita Iswari , Vasiliu Anca , Saluzzo Francesca , Akkerman Onno W.
Published: November 2024

The global burden of drug-resistant tuberculosis (DR-TB) continues to challenge healthcare systems worldwide. There is a critical need to tackle DR-TB by enhancing diagnostics and drug susceptibility testing (DST) capabilities, particularly for emerging DR-TB drugs. This endeavor is crucial to optimize the efficacy of new therapeutic regimens and prevent the resistance and overuse of these invaluable weapons. Despite this urgency, there remains a lack of comprehensive review of public health measures aimed at improving the diagnostics and DST capabilities. In this review, we outline strategies to enhance the capabilities, especially tailored to address the challenges posed by resistance to new DR-TB drugs. We discuss the current landscape of DR-TB drugs, existing diagnostic and susceptibility testing methods, and notable gaps and challenges in these methods and explore strategies for ensuring fair access to DST while narrowing these disparities. The strategies include public health interventions aimed at strengthening laboratory infrastructure, workforce training, and quality assurance programs, technology transfer initiatives, involving drug developers in the DST development, establishing national or regional referral hubs, fostering collaboration and resources pooling with other infection control efforts, extending testing access in underserved areas through public–private partnerships, advocating for lowering costs or loans at low interest, remote technical support, and implementing mandatory molecular surveillance monitoring. This review underscores the urgent need to enhance DST capacities for new DR-TB drugs and identifies opportunities for innovation and improvement. Assessing the extent of the global health impact of these measures is crucial to ensure their effectiveness in combating DR-TB.
Involvement of ATF6 in Octreotide-Induced Endothelial Barrier Enhancement
Authors: Fakir Saikat , Barabutis Nektarios
Published: November 2024

Background/Objectives: Endothelial hyperpermeability is the hallmark of severe disease, including sepsis and acute respiratory syndrome (ARDS). The development of medical countermeasures to treat the corresponding illness is of utmost importance. Synthetic somatostatin analogs (SSA) are FDA-approved drugs prescribed in patients with neuroendocrine tumors, and they act via growth hormone (GH) suppression. Preclinical investigations suggest that Octreotide (OCT) alleviates Lipopolysaccharide (LPS)-induced injury. The aim of the study is to investigate the involvement of activating transcription factor 6 (ATF6) in the protective effects of OCT in endothelial dysfunction. To the best of our knowledge, the available information on that topic is limited. Methods: Human lung microvascular endothelial cells (HULEC-5a) and bovine pulmonary artery endothelial cells (BPAEC) which expressed elevated levels of ATF6 due to AA147 were exposed to OCT or vehicle. Protein expression, endothelial permeability, and reactive oxygen species (ROS) generation were assessed utilizing Western blot analysis, Fluorescein isothiocyanate (FITC)-Dextran assay, and Dichlorofluorescein diacetate measurements, respectively. Results: Our observations suggest that ATF6 activation significantly improves OCT-induced endothelial barrier enhancement. This combination led to increased expression of binding immunoglobulin protein (BiP) and glucose-regulated protein 94 (Grp94), which are downstream unfolded protein response (UPR) targets. Moreover, ATF6 activation prior to OCT treatment resulted in decreased activation of myosin light chain 2 (MLC2) and cofilin; and reduced reactive oxygen species (ROS) generation. ATF6 activation enhanced the anti-inflammatory effects of OCT, as reflected in the suppression of transducer and activator of transcription (STAT) 1, STAT3, and P38 phosphorylation. Conclusions: Our findings suggest that ATF6 activation prior to OCT treatment enhances the beneficial effects of OCT in the endothelium.
Population Pharmacokinetic and Pharmacodynamic Study of Palbociclib in Children and Young Adults with Recurrent, Progressive, or Refractory Brain Tumors
Authors: Panetta John C. , Selvo Nicholas S. , Mater David Van , Stewart Clinton F.
Published: November 2024

Background/Objectives: Palbociclib, an oral CDK 4/6 inhibitor, was evaluated in a Pediatric Brain Tumor Consortium (PBTC) phase 1 (NCT02255461; PBTC-042) study to treat children and young adults with recurrent, progressive, or refractory brain tumors. The objectives of this study were to characterize the palbociclib population pharmacokinetics in children enrolled on PBTC-042, to conduct a population pharmacodynamic analysis in this patient population, and to perform a simulation study to assess the role of palbociclib exposure on neutropenia and thrombocytopenia. Methods: The palbociclib population pharmacokinetics and pharmacodynamics were characterized in this patient population (n = 34 patients; 4.9–21.6 years old). Population pharmacokinetics were modeled using a one-compartment model with first-order absorption and elimination. Covariate analysis was performed, evaluating demographics, laboratory values, and concomitant medications. A pharmacodynamic model was used to describe the relation between palbociclib plasma exposure and changes in the ANC and platelet counts. Results: The population estimates for the apparent oral volume, apparent oral clearance, and absorption rate constant were 664.5 L/m2, 36.8 L/h/m2, and 0.48 h−1, respectively. The palbociclib apparent oral clearance was decreased in patients with higher AST values (p = 0.0066). The ANC and platelet pharmacodynamic models estimated that the median (5th–95th percentile) time individuals had grade 3 or greater neutropenia was 4 (0, 21) days. Simulations showed that given 75 mg/m2 palbociclib, 49% of the individuals were expected to have grade 3 or greater neutropenia. Conclusions: Palbociclib pharmacokinetics and pharmacodynamics were adequately characterized in this patient population, no unexpected adverse reactions were noted, and the drug was well tolerated.
Organic Moiety on Sn(IV) Does Matter for In Vitro Mode of Action: nBu3Sn(IV) Compounds with Carboxylato N-Functionalized 2-Quinolones Induce Anoikis-like Cell Death in A375 Cells
Authors: Kasalović Marijana P. , Jelača Sanja , Dimić Dušan , Maksimović-Ivanić Danijela , Jevtić Verica V. , Mijatović Sanja , Rüffer Tobias , Kaluđerović Goran N. , Pantelić Nebojša Đ.
Published: November 2024

Objectives: New tributyltin(IV) complexes containing the carboxylate ligands 3-(4-methyl-2-oxoquinolin-1(2H)-yl)propanoic acid (HL1) and 2-(4-methyl-2-oxoquinolin-1(2H)-yl)acetic acid (HL2) have been synthesized. Methods: Their structures have been determined by elemental microanalysis, FT-IR and multinuclear NMR (1H, 13C and 119Sn) spectroscopy and X-ray diffraction study. A solution state NMR analysis reveals a four-coordinated tributyltin(IV) complex in non-polar solvents, while an X-Ray crystallographic analysis confirms a five-coordinated trigonal-bipyramidal geometry around the tin atom due to the formation of 1D chains. A theoretical structural analysis was performed by optimization employing B3LYP-D3BJ functional and 6-311++G(d,p)/def2-TZVP(Sn) basis sets for H, C, N, O/Sn, respectively. The interactions between tin(IV) and surrounding atoms were examined by QTAIM approach. The in vitro antiproliferative activity of the synthesized compounds was evaluated by MTT and CV assays versus MCF-7 (human breast adenocarcinoma), HCT116 (human colorectal carcinoma), A375 (human melanoma), 4T1 (mouse breast carcinoma), CT26 (mouse colon carcinoma) and B16 (mouse melanoma) tumor cell lines. Results: Both synthesized compounds (nBu3SnL1 and nBu3SnL2) exerted powerful micromolar IC50 cytotoxicity values and demonstrated high selectivity toward malignant cells. Both experimental drugs affected cell adhesion and induced anchorage independent apoptosis, a favorable type of cell death with an essential role in cancer dissemination prevention. The BSA-binding affinity of the obtained organotin compounds was followed by spectrofluorometric titration and molecular docking simulations. Conclusions: The tributyltin(IV) compounds selectively induce anoikis-like cell death in A375 cells, also highlighting the importance of the organic moiety on the tin(IV) ion in the mechanism of action.
Performance Study of Random Layout Light Source for Visible Light Communication System
Authors: Ke Xizheng , Zheng Yuwei , Liang Jingyuan , Qin Huanhuan
Published: November 2024

In indoor visible light communication, a rational layout of light sources is required to ensure that multiple users at different locations in the room can obtain better communication quality and achieve uniform coverage of optical power on the receiving surface. The article investigates the performance of an indoor visible light communication system when the random layout of the Matern hardcore point process is used and compares it with the communication performance under the Poisson point process and the binomial point process. A particle swarm optimization algorithm is introduced based on the Matern hardcore point process, where the points generated under the Matern hardcore point process are used as the initial positions of the particles, and optimization adjustments are made according to the objective function to find the optimal layout. The results show that compared with the Poisson point process and the binomial point process, the use of the Matern hardcore point process to randomly lay out the LEDs makes the light intensity in the system more uniform and the numerical fluctuation of the received power is smaller. The uniformity of the indoor illumination after the combination of the Matern hardcore point process and the particle swarm optimization algorithm reaches 0.84, the deviation of the peak power is reduced by 20%, and the average signal-to-noise ratio value is 0.86, which is an increase in the average signal-to-noise ratio compared to the average signal-to-noise ratio before optimization.