bluuebunny/crossref_metadata_2025 huggingface dataset:
Mixed-methods analysis of personal growth in an equity-centered leadership development program
Authors: McKelvy Josephine , Du Chenguang , Song Michelle , Carr Tara , Berthiaume Rachel , Corbie Giselle , Fernandez Claudia , Dave Gaurav
Published: November 2024

Introduction:

Self-efficacy (or the belief in one’s ability to effect change) often moderates the relationship between education, interest, and actions in evaluations of training programs that prepare community-based investigators in the clinical and translational sciences workforce. Such evaluations, however, tend to emphasize individual-level attitudes when there are also community- or organizational-level outcomes impacted. Methods: This study uses a novel sequential, explanatory mixed-methods design to explore multiple levels of self-efficacy (or self-awareness of personal growth in leadership) in the Clinical Scholars program, an equity-centered leadership development program for mid- to later-career healthcare professionals. Our design involves: (1) bivariate correlations and confirmatory factor analysis of self-assessed competencies across all program participants to identify emergent combinations of competencies, which informed (2) more nuanced thematic coding of participants’ stories of most significant change in their personal and professional lives, as a result of the program. Results: In unpacking their accounts of personal leadership styles (that aligned with our quantitative analyses of competencies), we found that participants demonstrated multiple competencies simultaneously. Specifically, they employed emotionally intelligent learning and consensus-building dialogue to manage conflict for interpersonal impact. Additionally, they used this combination of skills to unite diverse stakeholders under a shared vision in order to lead and manage organizational change where all colleagues’ contributions were valued. Conclusion: Together, these methods extend our understanding of personal growth in leadership as an outcome of the program in terms of individual- and organizational-level impacts, using representative quantitative self-assessments to categorize rich qualitative descriptions.
Empiric antibiotic prescribing practices for gram-positive coverage of late-onset sepsis in neonatal intensive care units in North America
Authors: Petel Dara Simcha , Isabel Sandra , Lee Kyong-Soon , Ting Joseph Yuk , Kaufman David A , Sanchez Pablo Jose , Khan Sarah , Timberlake Kathryn , Wright James , Science Michelle
Published: November 2024

Late-onset sepsis (LOS) in the neonatal intensive care unit (NICU) causes significant morbidity and mortality, yet guidance on empiric management is limited. We surveyed NICUs across Canada and the United States regarding their empiric antimicrobial regimens for LOS, thereby identifying large practice variations and high rates of empiric vancomycin use.
Multiplexed gastrointestinal PCR panels for the evaluation of diarrhea in patients with acute leukemia
Authors: Ford Clyde D. , Lopansri Bert K. , Hunter Bradley D. , Wilkes Jacob , Asch Julie , Hoda Daanish
Published: November 2024

Objective:

To better delineate multiplexed gastrointestinal polymerase chain reaction (PCR) panel (MGPP) diagnostic and therapeutic stewardship for patients undergoing treatment for acute leukemia including indications and benefits of testing, optimal timing, and interpretation of results.

Study design:

We retrieved all MGPP ordered on 662 consecutive patients admitted with newly diagnosed acute leukemia between June 2015 and May 2024.

Setting:

Regional referral center for acute leukemia.

Results:

Fifty-one (17%) of 305 MGPP obtained on the 198 patients who underwent testing identified at least one and 4 (1%) more than one diarrheagenic pathogen. The probability of a positive result was greater if obtained as an outpatient [20/52(38%)], but was not related to type of leukemia, sex, or age. Among the positive results, the pathogens identified included Clostridioides difficile (78% of tests), norovirus (16%), diarrheagenic Escherichia coli (6%), adenovirus 40/41 (4%), and Giardia lamblia (4%). The results of 30 of the 305 tests resulted in a change in treatment (28 C. difficile, 2 G. lamblia). For the MGPP C. difficile results with an accompanying toxin determination, this included treatment following 16/19 tests with a positive toxin result and 11/19 with a negative. Actionable results other than C. difficile were rarely seen in the inpatient population.

Conclusions:

MGPP testing is most useful when administered as an outpatient and of little benefit for inpatients with hospital-onset diarrhea. Since MGPP is sensitive and does not distinguish between colonization and causes of diarrhea, caution is needed in interpretation of results, especially for toxin-negative C. difficile.
Sustainability of plastic waste management through voluntary initiatives: A case study in Indonesia
Authors: Rucevska Ieva , Ch. Tsakona Maria , Wermter Benedict
Published: November 2024

The plastic pollution crisis has resulted in the establishment of many voluntary plastic waste initiatives in Southeast Asia, where most of the plastic leakage occurs. This study aims to assess the sustainability of four types of voluntary, partly or fully externally funded plastic waste initiatives within Indonesia’s current waste management system and anticipate challenges that can arise in the future. The research used the qualitative approach of Strengths, Weaknesses, Opportunities and Threats and Internal and External Factors Analysis framework to evaluate the initiatives’ techno-economic, socio-cultural, legislative and environmental sustainability. The results showed that three out of four types of plastic waste initiatives were in the diversification quadrant, and one type was in the survival quadrant. The unfavoured position of the initiatives in the quadrant is mainly due to important regulatory gaps in Indonesia and the lack of a stable funding mechanism. The appropriate strategy for the voluntary plastic waste initiatives to be self-sustainable and a catalyst for sustainable national waste management is to exert pressure on the government to establish an institutionalised and legislated waste management system and endorse a mandatory implementation of the polluter pays principle. Otherwise, improving waste management systems in Indonesia at the macro level could be challenging to achieve.
The Necessity of Public Writing
Authors: Looser Devoney
Published: November 2024

Researchers need to reach a new academic normal in which virtually every piece of scholar-facing humanities work generates a public-facing writing component. This essay recounts interactions with a colleague who, in a curriculum meeting, described public humanities as “a hobby.” I suggest arguments and strategies to lead skeptical colleagues to re-envision the value and possibilities – and occasional dangers and pitfalls – of the public humanities. Public writing is a practice that academic humanists should regularly engage in and a mode we must be willing to teach in order to win back public trust in higher education and to reinvigorate humanities research at a time of precarity.
POINTS ON
$x^4+y^4=z^4$
OVER QUADRATIC EXTENSIONS OF
${\mathbb {Q}}(\zeta _8)(T_1,T_2,\ldots ,T_n)$
Authors: THO NGUYEN XUAN
Published: November 2024

Ishitsuka et al. [‘Explicit calculation of the mod 4 Galois representation associated with the Fermat quartic’, Int. J. Number Theory16(4) (2020), 881–905] found all points on the Fermat quartic
${F_4\colon x^4+y^4=z^4}$
over quadratic extensions of
${\mathbb {Q}}(\zeta _8)$
, where
$\zeta _8$
is the eighth primitive root of unity
$e^{i\pi /4}$
. Using Mordell’s technique, we give an alternative proof for the result of Ishitsuka et al. and extend it to the rational function field
${\mathbb {Q}}({\zeta _8})(T_1,T_2,\ldots ,T_n)$
.
Nutritional status of Saudi obese patients undergoing laparoscopic sleeve gastrectomy, one-year follow-up study
Authors: Alqahtani Seham J. , Alfawaz Hanan A. , Awwad Fuad A. , Almnaizel Ahmad T. , Alotaibi Anwar , Bajaber Adnan S. , El-Ansary Afaf
Published: November 2024

Bariatric surgery has significantly increased globally as an effective treatment for severe obesity. Nutritional deficits are common among candidates for bariatric surgery, and follow-up of nutritional status is critically needed for post-surgery healthcare management. This observational prospective study was conducted at King Khalid University Hospital in Riyadh. Samples were collected pre- and post-laparoscopic sleeve gastrectomy (LSG), with the visit intervals divided into four visits: pre-surgery (0M), 3 months (3M), 6 months (6M) and 12 months (12M). Food intake and eating patterns significantly changed during the first year (P < 0·001). The mean energy intake at 3M post-surgery was 738·3 kcal, significantly lower than the pre-surgery energy intake of 2059 kcal. Then, it increased gradually at 6M and 12M to reach 1069 kcal (P < 0·00). The intake of Fe, vitamin B12 and vitamin D was below the dietary reference intake recommendations, as indicated by the 24-hour dietary recall. The prevalence of 25 (OH) vitamin D deficiency improved significantly from pre- to post-surgery (P < 0·001). Vitamin B12 deficiency was less reported pre-LSG and improved steadily towards a sufficient post-surgery status. However, 35·7 % of participants were deficient in Fe status, with 28·6% being female at higher levels than males. While protein supplementation decreased significantly over the 12M follow-up, the use of vitamin supplements dramatically increased at 3 and 6M before declining at 12M. Fe and vitamin B12 were the most popular supplements after vitamin D. This study confirms the necessity for individualised dietary plans and close monitoring of candidates’ nutritional status before and after bariatric surgery.
Estimating Ideal Points of British MPs Through Their Social Media Followership
Authors: Gaughan Conor
Published: November 2024

Ideal points of MPs in the UK House of Commons (HoC) are characteristically difficult to ascertain due to tight party discipline and strategic voting by opposition members. This research note generates left/right ideal point estimates for 591 British MPs sitting in the HoC as of 22/08/2022, ascertained through their social media followership. Specifically, estimates are derived by conducting correspondence analysis (CA) on MP Twitter (X) follower networks, which are subsequently validated against an expert survey, confirming that these estimates have a high degree of between-party (R2 = 0.93) and within-party (Con: r = 0.84; Lab: r = 0.81) accuracy. The informative value of these estimates is then demonstrated by predicting candidate endorsement in the September 2022 Conservative leadership contest, confirming that an MP's ideal point was a statistically significant predictor of candidate endorsement, with Liz Truss drawing support primarily from the further right of the party.
“It's Not Our Responsibility, But We Need to Do Something”: Explaining Local Government Responses to the Homelessness and Housing Crises
Authors: Smith Alison
Published: November 2024

In the past five years, there has been a striking increase in the number of people experiencing homelessness, including unsheltered homelessness, across Canada (Infrastructure Canada, 2024). Facing this growing crisis, local governments are changing and expanding their responses. An important innovation is tiny homes, a form of deeply affordable and supportive housing for people leaving homelessness. In this brief article, I ask what explains local government's increased leadership and innovation with respect to homelessness and housing crises. Drawing on interviews and document analysis regarding the development of a tiny homes community in a mid-sized BC municipality, I identify three factors that have contributed to local government's policy innovation: 1) local officials are keenly aware of the inadequacies of federal and provincial responses and of the need for alternative approaches; 2) they hold important resources, notably local knowledge and land; and 3) they are facing pressure to respond from citizens and service providers.
Drug repurposing for hard-to-treat human alveolar echinococcosis: pyronaridine and beyond
Authors: Wang Weisi , Li Jun , Qi Wenjing , Chen Ying , Tian Mengxiao , Wu Chuanchuan , Zhang Yao , Yu Yingfang , Han Shuai , Han Xiumin , Duan Liping , Zhang Wenbao
Published: November 2024

Human alveolar echinococcosis is a hard-to-treat and largely untreated parasitic disease with high associated health care costs. The current antiparasitic treatment for alveolar echinococcosis relies exclusively on albendazole, which does not act parasiticidally and can induce severe adverse effects. Alternative, and most importantly, improved treatment options are urgently required. A drug repurposing strategy identified the approved antimalarial pyronaridine as a promising candidate against Echinococcus multilocularis infections. Following a 30-day oral regimen (80 mg kg−1 day−1), pyronaridine achieved an excellent therapeutic outcome in a clinically relevant hepatic alveolar echinococcosis murine model, showing a significant reduction in both metacestode size (72.0%) and counts (85.2%) compared to unmedicated infected mice, which revealed significantly more potent anti-echinococcal potency than albendazole treatment at an equal dose (metacestode size: 42.3%; counts: 4.1%). The strong parasiticidal activity of pyronaridine was further confirmed by the destructive damage to metacestode tissues observed morphologically. In addition, a screening campaign combined with computational similarity searching against an approved drug library led to the identification of pirenzepine, a gastric acid-inhibiting drug, exhibiting potent parasiticidal activity against protoscoleces and in vitro cultured small cysts, which warranted further in vivo investigation as a promising anti-echinococcal lead compound. Pyronaridine has a known drug profile and a long track record of safety, and its repurposing could translate rapidly to clinical use for human patients with alveolar echinococcosis as an alternative or salvage treatment.
Emergency Responses to COVID-19 and Opportunities for Inclusive Social Policy
Authors: Martínez Franzoni Juliana , Sánchez-Ancochea Diego
Published: November 2024

This article addresses whether responses to COVID-19 created opportunities for future policy change. We explore this matter by presenting a framework rooted in political economy and the literature on pandemics. We argue that the opportunities created by emergency responses are context-specific and that narratives, policy tools, and pro-equity state actors are variables that mediate emergency responses and future opportunities. We ground our analytical contribution on the emergency cash transfers deployed during 2020 following the COVID-19 outbreak in two contrasting Central American countries, Costa Rica and Guatemala. The paper promotes further policy discussion on the opportunities for progressive change in unequal contexts.
Robot imitation from multimodal observation with unsupervised cross-modal representation
Authors: Xu Xuanhui , You Mingyu , Zhou Hongjun , He Bin
Published: November 2024

Imitation from Observation (IfO) prompts the robot to imitate tasks from unlabeled videos via reinforcement learning (RL). The performance of the IfO algorithm depends on its ability to extract task-relevant representations since images are informative. Existing IfO algorithms extract image representations by using a simple encoding network or pre-trained network. Due to the lack of action labels, it is challenging to design a supervised task-relevant proxy task to train the simple encoding network. Representations extracted by a pre-trained network such as Resnet are often task-irrelevant. In this article, we propose a new approach for robot IfO via multimodal observations. Different modalities describe the same information from different sides, which can be used to design an unsupervised proxy task. Our approach contains two modules: the unsupervised cross-modal representation (UCMR) module and a self-behavioral cloning (self-BC)-based RL module. The UCMR module learns to extract task-relevant representations via a multimodal unsupervised proxy task. The Self-BC for further offline policy optimization collects successful experiences during the RL training. We evaluate our approach on the real robot pouring water task, quantitative pouring task, and pouring sand task. The robot achieves state-of-the-art performance.
Who Is Perceived as Deserving? How Social Identities Shape Attitudes about Disaster Assistance in the United States
Authors: Ross Ashley D. , Rouse Stella M. , Alcañiz Isabella , Marchevsky Alejandra
Published: November 2024

Research has shown that as the size of government assistance programs grow, and the recipients of such programs are increasingly non-white and/or non-citizen, public support for them declines. Our study examines this phenomenon on the question of deservingness in federal disaster assistance. Using a 2018 survey experiment that leverages two devastating hurricanes—Hurricane Maria and Hurricane Harvey—that hit different parts of the United States in 2017, we explore how the social identities of race/ethnicity and partisanship affect attitudes about disaster deservingness. Our results demonstrate that although federal disaster assistance has broad support, it is contingent on perceptions about the disaster victim and the type of assistance. Respondents were less likely to support disaster assistance to Hurricane Maria–affected people than those affected by Hurricane Harvey. Moreover, white and Republican respondents were more likely to favor market-based assistance whereas race-/ethnic-minority and Democratic respondents were more likely to support more generous forms of disaster assistance. These findings have important implications for the allocation of disaster funds as climate change intensifies and the frequency of billion-dollar disaster events increases. This is exacerbated by political polarization and heightened social vulnerability due to changing population demographics.
Climate, Conflict, and Context: Reevaluating Americans’ Support for Refugees
Authors: Lajevardi Nazita , Williams Tarah , Stewart Evan , Whitaker Roy
Published: November 2024

As more people are displaced by climate change, public acceptance of migrants is an increasingly relevant geographical and political issue. How willing are Americans to accept climate migrants and how does this support compare to others who are fleeing conflict? We conducted a nationally representative survey experiment (N=1,027) with prompts that varied the context of refugee resettlement, including a control condition without context, those displaced by global warming, refugees from Ukraine, and refugees from Afghanistan. Respondents expressed marginally lower willingness to admit climate migrants and significantly higher willingness to admit Ukrainian refugees. These differences were amplified by partisanship, religion, and race. These results suggest that some migrants experience a more welcoming public than others and highlight a challenge for those who are made vulnerable by climate change.
Beyond Changing Minds: Raising the Issue Importance of Expanding Legal Immigration
Authors: Kustov Alexander
Published: November 2024

How can public opinion change in a pro-immigration direction? Recent studies suggest that those who support immigration care less about it than those who oppose it, which may explain why lawmakers do not enact pro-immigration reforms even when voters are pro-immigration. To see if the personal issue importance of immigration can be changed, I conducted a probability-based, nationally representative US survey experiment (N = 3,450) exposing respondents to verifiable arguments about the broad national benefits of expanding legal immigration and the costs of not doing so. Using new measures of issue importance, my descriptive results show that only one-fifth of voters who prioritize the issue have a pro-immigration preference. Furthermore, while anti-immigration respondents prioritize policies regarding law enforcement and (reducing) future immigration, pro-immigration respondents prioritize (helping) immigrants already here. The experimental results confirm that the provided arguments raised immigration’s importance among pro-immigration voters but did not backfire by mobilizing anti-immigration voters. Contrary to expectations, the arguments increased pro-immigration policy preferences, but did not change voters’ subissue priorities within immigration or their willingness to sign a petition. Overall, the treatment was effective beyond changing minds by shifting stated issue positions and priorities in a pro-immigration direction. It can thus be used in a nontargeted information campaign to promote pro-immigration reforms.
Populism, non-state actors and right-wing legal mobilization in Europe
Authors: Kocemba Karolina , Stambulski Michał
Published: November 2024

This article serves as an introduction to the special issue on ‘Populism and Right-Wing Legal Mobilization in Europe’. We point to the dependence of populists in power on non-state actors: populist governments have ideological and political reasons to need the support of civil society’s right-wing representatives and have the financial and institutional means to strengthen those organizations. We then map right-wing legal mobilization in Europe based on the analyses in the special issue. By right-wing legal mobilization, we understand the organized efforts, resources, and strategies employed by individuals, groups, or organizations with conservative or right-leaning ideologies to embody their values in positive law and its interpretation. The text concludes with a dynamic normative framework to assess this type of mobilization. Drawing on recent contributions from comparative constitutional law, human rights, and socio-legal studies, we argue that the analysis and evaluation of right-wing legal mobilization could be based on a comprehensive analysis of three bundles of issues: (1) the relationship between mobilizing actors and the courts, as well as the local standard of judicial independence, (2) the relation of right-wing argumentation to systemic linkages and historical trajectories of human rights, (3) the redistributive effect (economic and symbolic) and the potential success of such mobilization on the legal capacities of other actors who may have opposing interests. From this perspective, the problematic part of right-wing legal mobilization in the context of populism is, therefore, not its ideological, conservative character but its influence on the rule of law to gain strategic advantage. In the process, the very idea of the rule of law and the related issue of civic agency may be compromised.
Mapping the potentials and pitfalls of using European law for strategic litigation against illiberal reforms
Authors: Cebulak Pola
Published: November 2024

The toolbox for resisting illiberalism is quite diverse. It includes high-level diplomatic negotiations concerning sanctions to enforce democracy and citizens’ mobilisation for local causes. This article focuses on strategic litigation as legal mobilisation, relying on the language of rights and the rule of law and addressing courts as defenders of liberal democracy. Such mobilisation leads to litigation before national and European courts concerning issues such as media freedom, judicial independence, minority rights or the rights of migrants. In order to be authoritative, however, courts need support from political institutions at national and EU levels from the transnational judicial community and from civil society. The embeddedness in structured civil causes and organisations seems particularly relevant in the context of strategic litigation. This article aims to map out particular factors in the EU legal and institutional systems that directly affect the prospects of strategic litigation against illiberal reforms using EU law.

On the one hand, the EU legal system does not provide direct access to the Court of Justice of the EU (CJEU). The multilevel system of judicial protection in the EU means that litigation aimed at resisting illiberalism mostly needs to start before national courts, making it vulnerable to political capture of national judiciary. On the other hand, the EU law system is based on the purposive constitutional framework of the Treaties. The tendency to follow a teleological interpretation of the CJEU makes it a promising ground for advocating for new interpretations of the law in light of a changing social context. Finally, EU law is a system with a particular legal culture and a field of experts who are well-versed in applying that culture. This field does not directly overlap with the specialised lawyers who often initiate strategic litigation; who tend to be experts in the fields of migration, transparency or the environment; and who do not have a broader understanding of EU law and its integration logic.
How conservative groups fight liberal values and try to ‘moralize’ the European Court of Human Rights
Authors: Cliquennois Gaëtan , Chaptel Simon , Champetier Brice
Published: November 2024

This paper analyses the growing litigation before the European Court of Human Rights (ECtHR) by conservative European Non-governmental Organizations (NGOs) who exploit legal opportunities and other advocacy tactics. These actors oppose the liberal insistence on permissive individual freedom, minority rights and mandatory vaccination. Instead, they promote the sanctity of life, traditional values and harsh terrorism penalties. In this study we show that conservative legal mobilisation is not only related to litigation but also covers the execution of certain ECtHR judgments and the nomination of some European judges. We analyse their tactics using legal and sociolegal methodology (interviews, analysis of legal documents and jurisprudence and network analysis) to characterise their influence on the European human rights system and the reactions of the Council of Europe. We reflect on the moral values claimed by conservative NGOs and their liberal counterparts by analysing how powerful private actors, driven by material and moral interests, take creative initiatives that shape or reshape case law and its politicisation through alliances with so-called ‘illiberal’ and ‘populist’ states.
Using liberal–legal tools for illiberal gains: the European Court of Human Rights and legal mobilisation by conservative right-wing actors
Authors: Blokker Paul
Published: November 2024

The role of social movements and civil society actors in rights advancement has been frequently emphasised. The assumption is that legal mobilisation by civil society actors works towards the extension of rights and the emancipation and advancement of justice for distinctive (minority) groups in society. While traditionally, socio-legal attention on social movement and civil society actions around rights promotion was particularly prominent in the US, for some time now the European context has also been approached from such a socio-legal lens. However, a one-sided, liberal–progressive understanding of social mobilisation around rights has, importantly, been put to the test by recent manifestations of societal actors. Conservative actors tend to (1) promote a restrictive interpretation or a radical reinterpretation of existing rights (e.g. abortion, free speech), (2) limit the diffusion of new rights (e.g. the rights to euthanasia or legalizing surrogate maternity) and/or (3) call for the interruption of the further extensions of rights (e.g. with regard to same-sex marriage, LGBTIQ issues). The analysis of legal mobilisation by such conservative right-wing actors indicates that mobilisational repertoires are strikingly similar to those of liberal actors. This article will discuss the notions of civil society and legal mobilisation and call for a rethinking of these concepts, in part because of the increasing manifestation of societal actors that are in contrast to the traditional liberal paradigm. The article will subsequently engage in a detailed study of one such actor – the Polish legal think tank Ordo Iuris (OI) – with regard to its third-party or amicus curiae interventions at the European Court of Human Rights (ECtHR), stressing the difference of orientation of such interventions from those of liberal actors and also indicating dimensions of ambivalence and similarity in their approaches.
Ethnic diversity and political trust at the onset of the COVID-19 pandemic
Authors: Schraff Dominik , Hegewald Sven
Published: November 2024

Current research faces challenges in explaining how contextual factors account for variations in the rally effect in political trust during the COVID-19 pandemic. While systematic explanations of country-level differences are hard to establish by means of cross-sectional comparisons, we propose to compare subnational areas within a country to learn more about the role of contextual factors. In this research note, we argue that ethnic diversity is a crucial contextual factor that helps researchers understand differences in political trust at the onset of the pandemic. Specifically, we propose that the rally effect should be restricted to ethnically more homogeneous contexts. An analysis of geocoded household panel data from the Netherlands reveals a strong rally effect in ethnically homogenous areas, while political trust in ethnically diverse contexts appears not to respond to the pandemic. This suggests an entrenched geography of political trust, which is associated with ethnic divides and is even maintained under crisis.
How an Ocean-Sized Lake May Have Formed on Ancient Mars
Authors: Sidik Saima
Published: November 2024

The catastrophic collapse of Mars’s atmosphere may have melted its polar ice cap, creating an ice-covered southern sea.
Observational Constraints on the Spatial Effect of Greenness and Canopy Cover on Urban Heat in a Major Midlatitude City
Authors: Lee Jangho , Berkelhammer Max
Published: November 2024

Urban heat stress is a critical issue, particularly in cities where dense infrastructure and limited green space exacerbate temperature extremes. This study investigates the impact of greenery (EVI2), canopy cover (CC), impervious cover (IC), and water bodies on heat index in Chicago using high‐resolution data from the Heat Watch campaign. We find that EVI2, CC and proximity to water body significantly reduce heat while IC increases heat, particularly in the afternoon when solar radiation is intense. Additionally, the effective radius that land cover impacts heat is smaller in the afternoon. The combined effect analysis indicates that enhancing total greenness, not just canopy cover, is the most effective strategy to reduce heat. This study underscores the importance of strategic vegetation management, highlighting the critical role of integrated approaches in reducing urban heat.
A Mystery of the Inconsistency Between Microwave Polarimetric Observations and Radiative Transfer Simulations
Authors: Zhu Ziqiang , Weng Fuzhong
Published: November 2024

A factor of 2 difference is found between microwave brightness temperature (TB) observations and simulations from vector radiative transfer models. A physical explanation of this difference is related to the calibration process. In principle, for the calibration of polarimetric instruments of a total power radiometer, the radiation should be only half of the values derived from Planck function but in the actual calibration process, a full value is used. When this full value is converted to a TB it is approximately, but not exactly, twice the TB simulated by a vector radiative transfer model. This inconsistency is verified by simulations of three conically scanning microwave imagers (WindSat, AMSR2 and MWRI) and one cross‐track scanning microwave sounder (AMSU‐A). This difference cannot be compensated simply by dividing a factor of 2 to the processed TBs, especially at high frequencies or at low physical temperatures due to the nonlinear property of Planck function.
Impact of the Offshore Seismograph Network and 3‐D Seismic Velocity Structure Model on Centroid Moment Tensor Analysis for Offshore Earthquakes: Application to the Japan Trench Subduction Zone
Authors: Yamaya Lina , Kubo Hisahiko , Shiomi Katsuhiko , Takemura Shunsuke
Published: November 2024

Recently, a widespread and densely continuous‐recording ocean‐bottom seismograph network has been deployed in the Japan Trench subduction zone. Utilizing the offshore network data improves azimuthal station coverage for offshore earthquakes in the Japan Trench subduction zone. It has a potential to obtain centroid moment tensor (CMT) solutions more accurately than conventional analyses using onshore networks and a simple one‐dimensional seismic velocity structure model. In this study, we conducted CMT inversion for subduction zone earthquakes that occurred between 1 April 2017, and 31 March 2024, with a moment magnitude range of 5.2–7.0. We used seismograms obtained from both the offshore and onshore networks. We calculated Green's functions using a three‐dimensional seismic velocity structure model. Our CMT solutions with thrust‐type mechanisms mostly indicated depths and dip angles consistent with the plate interface. For earthquakes in the outer‐rise region, our CMT solutions were characterized as normal‐fault mechanisms. The joint use of the offshore and onshore networks reduced the estimation errors of the CMT solutions compared with the only use of the onshore network, although the optimal solutions were consistent. The dip angles for the thrust earthquakes determined by our analysis were more consistent with the dip angle of the plate boundary than those determined by conventional CMT analyses. Additionally, we found that the conventional CMT analysis could introduce a systematic bias in depth and magnitude determinations. This finding highlights the importance of an offshore seismograph network and a reliable seismic velocity structure model for CMT inversions.
Intensification of an Autumn Tropical Cyclone by Offshore Wind Farms in the Northern South China Sea
Authors: Deng Shaokun , Chen Shengli , Sui Yi , Hu Zhen‐Zhong
Published: November 2024

The rapid development of the wind industry is accompanied by increasing environmental impacts. Currently, there is a lack of research on the impacts of offshore wind farm (OWF) on tropical cyclone (TC) intensity, including the mechanisms involved. This research is carried out by using a coupled and an uncoupled numerical model to investigate the impact of OWF on an autumn TC in the northeastern South China Sea. The results show that the wind speed deficit caused by OWF leads to an increase in surface pressure on the inflow side. This causes the surface pressure in the TC periphery to increase by advection, even if the TC is some distance away from the OWF. The increase in pressure gradient from the periphery to the TC center enhances the TC secondary circulation, thereby intensifying the TC. When the TC enters the OWF, the above mechanisms weaken and the ocean dominates the TC intensification. This is because the reduction in wind speed caused by the OWF results in a weaker sea surface current velocity, which weakens the flow of upstream cold water into the OWF, warming the sea surface temperature (SST) within the OWF. This implies that the horizontal gradient of the local SST is an important factor to be considered in the development of OWF. Sensitivity experiments indicate that OWF can also intensify other types of TC, and that higher cut‐out wind speeds lead to stronger intensification effects. These results also provide a new perspective on TC intensity forecasts.
Greenhouse Warming Potential of a Suite of Gas Species on Early Mars Evaluated Using a Radiative‐Convective Climate Model
Authors: Jorge Jason , Wordsworth Robin , Adams Danica
Published: November 2024

Abundant geomorphological and geochemical evidence of liquid water on the surface of early Mars during the late Noachian and early Hesperian periods needs to be reconciled with a fainter young Sun. While a dense atmosphere and related warming mechanisms are potential solutions to the early Mars climate problem, further investigation is warranted. Here, we complete a comprehensive survey of the warming potential of all known greenhouse gases and perform detailed calculations for 15 different minor gas species under early Martian conditions. We find that of these 15 species, , , , , and cause significant greenhouse warming at concentrations of 0.1 ppmv or greater. However, the most highly effective greenhouse gas species also tend to be more condensable, soluble and vulnerable to photolytic destruction. To provide a reference for future atmospheric evolution and photochemical studies, we have made our warming potential database freely available online.
Genetic and functional analyses of CTBP2 in anorexia nervosa and body weight regulation
Authors: Giuranna Johanna , Zheng Yiran , Brandt Matthäus , Jall Sigrid , Mukherjee Amrita , Shankhwar Soni , Renner Simone , Kurapati Nirup Kumar , May Caroline , Peters Triinu , Herpertz-Dahlmann Beate , Seitz Jochen , de Zwaan Martina , Herzog Wolfgang , Ehrlich Stefan , Zipfel Stephan , Giel Katrin , Egberts Karin , Burghardt Roland , Föcker Manuel , Marcus Katrin , Keyvani Kathy , Müller Timo D. , Schmitz Frank , Rajcsanyi Luisa Sophie , Hinney Anke
Published: November 2024

The C-terminal binding protein 2 (CTBP2) gene (translational isoforms: CTBP2-L/S, RIBEYE) had been identified by a cross-trait analysis of genome-wide association studies for anorexia nervosa (AN) and body mass index (BMI). Here, we did a mutation analysis in CTBP2 by performing polymerase chain reactions with subsequent Sanger-sequencing to identify variants relevant for AN and body weight regulation and ensued functional studies. Analysis of the coding regions of CTBP2 in 462 female patients with AN (acute or recovered), 490 children and adolescents with severe obesity, 445 healthy-lean adult individuals and 168 healthy adult individuals with normal body weight detected 24 variants located in the specific exon of RIBEYE. In the initial analysis, three of these were rare non-synonymous variants (NSVs) detected heterozygously in patients with AN (p.Arg72Trp - rs146900874; p.Val289Met -rs375685611 and p.Gly362Arg - rs202010294). Four NSVs and one heterozygous frameshift variant were exclusively detected in children and adolescents with severe obesity (p.Pro53Ser - rs150867595; p.Gln175ArgfsTer45 - rs141864737; p.Leu310Val - rs769811964; p.Pro397Ala - rs76134089 and p.Pro402Ser - rs113477585). Ribeye mRNA was detected in mouse hypothalamus. No effect of fasting or overfeeding on murine hypothalamic Ribeye expression was determined. Yet, increased Ribeye expression was detected in hypothalami of leptin-treated Lepob/ob mice. This increase was not related to reduced food intake and leptin-induced weight loss. We detected rare and frequent variants in the RIBEYE specific exon in both patients with AN and in children and adolescents with severe obesity. Our data suggest RIBEYE as a relevant gene for weight regulation.
Model-based characterization of total serum bilirubin dynamics in preterm infants
Authors: Chen Meng , Beuchée Alain , Levine Emmanuelle , Storme Laurent , Gascoin Geraldine , Hernández Alfredo I.
Published: November 2024

Objectives

This study aims to characterize the age-related natural dynamics of total serum bilirubin (TSB) in preterm infants through a mathematical model and to study the model parameters as potential biomarkers for detecting associated morbidities.

Methods

We proposed an exponential decay model and applied it to each infant. Patient-specific parameters were obtained by minimizing the error between measured TSB and model output. Modeling evaluation was based on root-mean-square error (RMSE). The occurrence of high-risk clinical events was analyzed based on RMSE.

Results

In a subset of the CARESS-Premi study involving 373 preterm infants (24–32 weeks’ gestation), 72 patient-specific models were fitted. RMSE ranged from 1.20 to 40.25 µmol/L, with a median [IQR] of 8.74 [4.89, 14.25] µmol/L.

Conclusions

Our model effectively characterized TSB dynamics for 72 patients, providing valuable insights from model parameters and fitting errors. To our knowledge, this is the first long-term mathematical description of natural TSB decay in preterm infants. Furthermore, the model was able to estimate the occurrence of clinical events such as necrotizing enterocolitis, as reflected by the relatively high RMSE. Future implications include the development of model-based clinical decision support systems for optimizing NICU monitoring and detecting high-risk events.

Impact

The study characterizes the natural dynamics of total serum bilirubin in preterm infants (24–32 weeks’ gestation) using a patient-specific exponential decay model.

The model describes patient-specific patterns of TSB evolution from day three to the first weeks, providing a median [IQR] root-mean-squared error of 8.74 [4.89, 14.25] µmol/L.

Complementary to previous studies focusing on the first 72–96 h, our study emphasizes the later decay course, contributing to a comprehensive long-term characterization of the natural TSB dynamics in preterm infants.

The proposed model holds potential for clinical decision support systems for the optimization of NICU monitoring and high-risk event detection.
Genetic engineering and the eye
Authors: Murphy Rory , Martin Keith R.
Published: November 2024

The transformative potential of genetic engineering in ophthalmology is remarkable, promising new treatments for a wide range of blinding eye diseases. The eye is an attractive target organ for genetic engineering approaches, in part due to its relatively immune-privileged status, its accessibility, and the ease of monitoring of efficacy and safety. Consequently, the eye has been at the forefront of genetic engineering advances in recent years. The development of Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9), base editors, prime editors, and transposases have enabled efficient and specific gene modification. Ocular gene therapy continues to progress, with recent advances in delivery systems using viral / non-viral vectors and novel promoters and enhancers. New strategies to achieve neuroprotection and neuroregeneration are evolving, including direct in-vivo cell reprogramming and optogenetic approaches. In this review, we discuss recent advances in ocular genetic engineering, examine their current therapeutic roles, and explore their potential use in future strategies to reduce the growing burden of vision loss and blindness.
Estimation of Jacquard’s genetic identity coefficients with bi-allelic variants by constrained least-squares
Authors: Graffelman Jan , Weir Bruce S. , Goudet Jérôme
Published: November 2024

The Jacquard genetic identity coefficients are of fundamental importance in relatedness research. We address the estimation of these coefficients as well as other relationship parameters that derive from them such as kinship and inbreeding coefficients using a concise matrix framework. Estimation of the Jacquard coefficients via likelihood methods and the expectation–maximization algorithm is computationally very demanding for large numbers of polymorphisms. We propose a constrained least squares approach to estimate the Jacquard coefficients. A simulation study shows constrained least squares achieves root-mean-squared errors that are comparable with those of the maximum likelihood approach, in particular when founder allele frequencies are unknown, while obtaining enormous computational savings.
Nuclear receptor E75/NR1D2 promotes tumor malignant transformation by integrating Hippo and Notch pathways
Authors: Wang Xianping , Guo Yifan , Lin Peng , Yu Min , Song Sha , Xu Wenyan , Kong Du , Wang Yin , Zhang Yanxiao , Lu Fei , Xie Qi , Ma Xianjue
Published: November 2024

Hormone therapy resistance and the ensuing aggressive tumor progression present a significant clinical challenge. However, the mechanisms underlying the induction of tumor malignancy upon inhibition of steroid hormone signaling remain poorly understood. Here, we demonstrate that Drosophila malignant epithelial tumors show a similar reduction in ecdysone signaling, the main steroid hormone pathway. Our analysis of ecdysone-induced downstream targets reveals that overexpression of the nuclear receptor E75, particularly facilitates the malignant transformation of benign tumors. Genome-wide DNA binding profiles and biochemistry data reveal that E75 not only binds to the transcription factors of both Hippo and Notch pathways, but also exhibits widespread co-binding to their target genes, thus contributing to tumor malignancy. We further validated these findings by demonstrating that depletion of NR1D2, the mammalian homolog of E75, inhibits the activation of Hippo and Notch target genes, impeding glioblastoma progression. Together, our study unveils a novel mechanism by which hormone inhibition promotes tumor malignancy, and describes an evolutionarily conserved role of the oncogene E75/NR1D2 in integration of Hippo and Notch pathway activity during tumor progression.
Structural basis of 3′-tRNA maturation by the human mitochondrial RNase Z complex
Authors: Valentín Gesé Genís , Hällberg B Martin
Published: November 2024

Maturation of human mitochondrial tRNA is essential for cellular energy production, yet the underlying mechanisms remain only partially understood. Here, we present several cryo-EM structures of the mitochondrial RNase Z complex (ELAC2/SDR5C1/TRMT10C) bound to different maturation states of mitochondrial tRNAHis, showing the molecular basis for tRNA-substrate selection and catalysis. Our structural insights provide a molecular rationale for the 5′-to-3′ tRNA processing order in mitochondria, the 3′-CCA antideterminant effect, and the basis for sequence-independent recognition of mitochondrial tRNA substrates. Furthermore, our study links mutations in ELAC2 to clinically relevant mitochondrial diseases, offering a deeper understanding of the molecular defects contributing to these conditions.
PTGS is dispensable for the initiation of epigenetic silencing of an active transposon in Arabidopsis
Authors: Trasser Marieke , Bohl-Viallefond Grégoire , Barragán-Borrero Verónica , Diezma-Navas Laura , Loncsek Lukas , Nordborg Magnus , Marí-Ordóñez Arturo
Published: November 2024

Transposable elements (TEs) are repressed in plants through transcriptional gene silencing (TGS), maintained epigenetic silencing marks such as DNA methylation. However, the mechanisms by which silencing is first installed remain poorly understood in plants. Small interfering (si)RNAs and post-transcriptional gene silencing (PTGS) are believed to mediate the initiation of TGS by guiding the first deposition of DNA methylation. To determine how this silencing installation works, we took advantage of ÉVADÉ (EVD), an endogenous retroelement in Arabidopsis, able to recapitulate true de novo silencing with a sequence of PTGS followed by a TGS. To test whether PTGS is required for TGS, we introduce active EVD into RNA-DEPENDENT-RNA-POLYMERASE-6 (RDR6) mutants, an essential PTGS component. EVD activity and silencing are monitored across several generations. In the absence of PTGS, silencing of EVD is still achieved through installation of RNA-directed DNA methylation (RdDM). Our study shows that PTGS is dispensable for de novo EVD silencing. Although we cannot rule out that PTGS might facilitate TGS, or control TE activity, initiation of epigenetic silencing can take place in its absence.