bluuebunny/crossref_metadata_2025 huggingface dataset:
A Multi-omics Study of Circulating Phospholipid Markers of Blood Pressure
Authors: Liu Jun , de Vries Paul S. , M. Fabiola Del Greco , Johansson Åsa , Schraut Katharina E. , Hayward Caroline , Dijk Ko Willems van , Franco Oscar. H. , Hicks Andrew A. , Vitart Veronique , Rudan Igor , Campbell Harry , Polašek Ozren , Pramstaller Peter P. , Wilson James F. , Gyllensten Ulf , Duijn Cornelia M. van , Dehghan Abbas , Demirkan Ayşe
Published: June 2021

Background High-throughput techniques allow us to measure a wide-range of phospholipids which can provide insight into the mechanisms of hypertension. We aimed to conduct an in depth multi-omics study of various phospholipids with systolic blood pressure (SBP) and diastolic blood pressure (DBP).Methods The associations of blood pressure and 151 plasma phospholipids measured by electrospray ionization tandem mass spectrometry were performed by linear regression in five European cohorts (n = 2,786 in discovery and n = 1,185 in replication). We further explored the blood pressure-related phospholipids in Erasmus Rucphen Family (ERF) study by associating them with multiple cardiometabolic traits (linear regression) and predicting incident hypertension (Cox regression). Mendelian Randomization (MR) and phenome-wide association study (pheWAS) were also explored to further investigate these association results.Results We identified six phosphatidylethanolamines (PE 38:3, PE 38:4, PE 38:6, PE 40:4, PE 40:5 and PE 40:6) and two phosphatidylcholines (PC 32:1 and PC 40:5) which together predicted incident hypertension with an area under the curve (AUC) of 0.61. The identified eight phospholipids are strongly associated with triglycerides, obesity related traits (e.g. waist, waist hip ratio, total fat percentage, body mass index, lipid-lowering medication, and leptin), diabetes related traits (e.g. glucose, insulin resistance and insulin) and prevalent type 2 diabetes. The genetic determinants of these phospholipids also associated with many lipoproteins, heart rate, pulse rate and blood cell counts. No significant association was identified by bi-directional MR approach.Conclusion We identified eight blood pressure-related circulating phospholipids that have a predictive value for incident hypertension. Our cross-omics analyses show that phospholipid metabolites in the circulation may yield insight into blood pressure regulation and raise a number of testable hypothesis for future research.
MIR17HG Polymorphisms Contribute to High Altitude Pulmonary Edema Susceptibility in Chinese Population
Authors: Si Lining , Wang Haiyuan , Wang Rong , Long Qifu , Zhao Yanli
Published: June 2021

Background: High-altitude pulmonary edema (HAPE) is a common acute altitude sickness. The results from existing studies have shown that the occurrence of HAPE is related to genetic factors. Therefore, six locis of MIR17HG were selected to study its effect on HAPE of Chinese population.Methods: All subjects were genotyped by the Agena MassARRAY, and the relationship between polymorphisms on MIR17HG and HAPE risk was evaluated using a χ2 test with an odds ratio (OR) and 95% confidence intervals (CIs) in multiple genetic models.Results: In the allele model, we observed that lower risk (OR = 0.74, p = 0.036) of the A allele for rs7318578 on the MIR17HG compared to the people with the C allele. Logistic regression analysis of four models for all selected MIR17HG SNPs between cases and controls showed significant differences for rs7318578 (OR = 0.74, p = 0.037) and rs17735387 (OR = 1.51, p = 0.036) in the HAPE population. Conclusion: Rs7318578 and rs17735387 on MIR17HG were associated with the genetic susceptibility of HAPE in Chinese population.
The Cost of Inappropriate Referral Pathways in Inpatient Care for Three Major Noncommunicable Diseases in Mongolia: A Registry-Based Analysis
Authors: Tuvdendorj Ariuntuya , Dechinkhorloo Otgonjargal , Dorjsuren Bayarsaikhan , Buskens Erik , Feenstra Talitha
Published: June 2021

Background: Non-communicable diseases (NCDs) consistently pose a huge economic burden to health systems and countries in general. The aim of this study was to quantify inpatient costs associated with chronic obstructive pulmonary disease, stroke and ischemic heart disease stratified by type of referral pathway, and to investigate key factors that drive these costs. Methods: A registry-based data analysis was performed using national public hospital inpatient records from 2016 to 2018 for 117,600 unique patients and linking patient-level inpatient health care use with hospital-specific unit cost per bed-day. These were combined to calculate the annual inpatient costs for each of the three disorders per person and per year. Generalized linear modeling was used to assess the association of inpatient costs with age, gender, location, comorbidity, treatment referral pathways and years.Results: Across three diagnoses, the majority of patients were female. Most were over 50-60 years old, with more than half being a pensioner, typically with at least one comorbidity. About 25% of patients followed what might be considered inappropriate (unofficial) inpatient referral pathways. Mean annual inpatient costs were int$ 721. These costs rose to int$ 849 for unofficial pathways and dropped to int$677 for official pathways. Further covariates significantly associated with high inpatient costs were location, age, gender, and comorbidity. Conclusion: Our findings provide background information essential to develop evidence-based and cost-effective interventions aimed at health promotion, prevention and service delivery. Reducing the unofficial use of inpatient care can improve efficient resource allocation in health care and prevent further escalation of inpatient costs in the future.
Synthesis of PANI@ZnO Hybrid Material and Evaluations in Adsorption of Congo Red and Methylene Blue Dyes: Structural Characterization and Adsorption Performance
Authors: Toumi Imane , Djelad Halima , Chouli Faiza , Abdelghani Benyoucef
Published: June 2021

In this research, a simple oxidation chemical process was applied for the synthesis of novel PANI@ZnO nanocomposite. The prepared nanocomposites were characterized by XPS, XRD, FTIR, SEM, TGA and N2 adsorption-desorption isotherms. Thereby, PANI@ZnO highest SBET values (about 40.84 m2.g− 1), total mesoporous volume (about 3.214 cm3.g− 1) and average pore size (about 46.12 nm). Afterwards, the prepared nanomaterial was applied as novel nanoadsorbent for the adsorption of Congo Red (CR) and Methylene Blue (MB) dyes from aqueous solutions at 298 K and pH 5.0. Besides, the pseudo-second-order model was obtained the best for the adsorption of both dyes. In the case of isotherm models, the Freundlich model showed the best fit. After removal, the spent adsorbent was regenerated. With the regeneration repeated five cycles, the PANI@ZnO regeneration efficiency remained at a very adequate level.
Robust vibration-based faults diagnosis machine learning model for rotating machines to enhance plant reliability
Authors: Espinoza-Sepulveda Natalia F. , Sinha Jyoti K.
Published: June 2021

Plant availability and reliability can be improved through a robust condition monitoring and fault diagnosis model to predict the current status (healthy or faulty) of any machines and critical assets. The model can then predict the exact fault for the faulty asset so that remedial maintenance can be carried out in a planned plant outage. Nowadays, the artificial intelligence (AI)-based machine learning (ML) model seems to be current trend to meet these requirements. Hence, the paper is also proposing such vibration-based faults diagnosis ML model through an experimental rotating rig. Here, the 2-Steps approach is used with the ML model to easy the industrial operation and maintenance process. The Step-1 provides the information about the asset health status such as healthy or faulty. The Step-2 then identifies the exact nature of fault to aid the decision making for the fault rectification and maintenance activities to avoid the risk of failure and enhance the reliability.
PM4 SMP model proposed for system reliability criticality assessment and maintainability improvement
Authors: Akaeje Ogechukwu , Billington Martin , Sinha Jyoti
Published: June 2021

This paper gives a practical systematic approach towards the maintenance procedure optimisation of a critical industrial unit in operation, to improve its maintainability. The resolution of the maintainability challenge in the industrial unit (Vibrating screen unit - VSU) was realised by performing a two-phase critical analysis, encompassing criticality and maintainability assessment. The criticality assessment comprised of failure investigation using fault tree analysis (FTA), vulnerability analysis using reliability block diagram (RBD), and failure mode effect and criticality analysis (FMECA). Furthermore, a maintainability assessment was performed on the industrial unit and improvement opportunities were identified. A generic model (PM4 Model) was conceptualised and used to improve the mean time to repair (MTTR) through a well-documented standard maintenance procedure (SMP).
Dantel Efektli Kumaş Tasarımlarının Erkek Giyiminde Kullanımı Üzerine Bir Önerme
Authors: Ağca Gözde , Öğüt Leyla
Published: June 2021

Dantel sanatı, özenli ve naif örnekleri ile dekoratif sanatlar arasında yer almaktadır. Araçları, teknikleri, tasarımı, üretimi ve uygulamaları ile yoğun emek gerektiren birçok süreci içerisinde barındırmaktadır. Dantel örnekleri, özellikle Orta Çağ’dan Sanayi Devrimi’ne kadar olan süreçte hem kadın hem de erkek giyiminde rol almış, dönemin modasına göre; motifleri, teknikleri ve kullanım alanları değişiklik göstermiştir. Özellikle Rönesans Dönemi’nde Avrupa dantelleri altın çağını yaşamış, kadın giyiminin yanı sıra erkek giysilerinde de yakalar, manşetler, çorap süslemeleri, aksesuarlar vb. alanlarda kullanılarak bir statü göstergesine dönüşmüştür.

Geçmişten günümüze zaman zaman yükselen bir değer olmanın yanında zarif dekoratif yüzey etkileriyle çeşitli alanlarda da bir esin kaynağı olmaya devam etmektedir. Özellikle dijital baskı teknolojileri; daha geniş renk aralığında, daha hızlı, daha ekonomik ve daha çevreci baskı olanaklarıyla her türlü desenin basılmasına olanak sağlamaktadır. Yapımı oldukça zahmetli olan dantel sanatı, Sanayi Devrimi sonrasında varlığını çoğunlukla makine dantelleri ile sürdürmüş, zaman zaman da farklı efekt, farklı renk kombinasyonları ile giyim, ev tekstili, ev dekorasyonu, ambalaj tasarımları gibi pek çok ürünün yüzey baskı tasarımlarında yer almıştır.

Bu çalışma, geleneksel dantellerin dijital çözümlemesinin yapılarak dijital baskı tasarımları ile yeniden yorumlanmasını ve giysilik kumaş koleksiyonu oluşturulmasını kapsamaktadır. Özellikle kadın giyiminde tercih edilen dantel ve dantel yüzeylerin erkek giyiminde kullanılma önerilerini içermektedir.
Mekan ve Varoluş İlişkisi Bağlamında Charles Simonds’un Küçük İnsan Meskenleri
Authors: Barlas Mert
Published: June 2021

Bu araştırmada, Amerikalı heykeltıraş Charles Simonds'un, 70’li yıllardan günümüze şekillendirdiği, kaynağını Simonds’un kendi yarattığı Küçük İnsanlar mitolojisinden alan eserleri, mekân ve var oluş/ yok oluş ilişkisi bağlamında incelenmiştir. Sanatçının, Küçük İnsanlar'ın varoluş alanları olarak biçimlendirdiği küçük ölçekli mekân yaratıları olan eserleri, kimi zaman kamusal alana sanat aracılığıyla müdahale eden pratikler kimi zaman galeri mekânlarına yönelik kurgular olarak ortaya çıkmaktadır. Bu anlamda araştırma, Simonds'un, sokak sanatının bir örneği olarak da ele alınan Dwelling serileri ile sınırlandırılmıştır. Bu serilere ait eserler, Küçük İnsanlar mitolojisinin ve onların yerleşkelerinin yaratılışını temsil eden Birth ve Landscape/Body/Dwelling performansları ile birlikte, doğum, yaşam, yok olma/ölüm gibi varoluşsal olguların mekân fenomeni ile olan ilişkileri dikkate alınarak incelenmiştir. Ayrıca, Simonds’un eserlerinde ele aldığı malzemenin geçicilik bağlamıyla olan ilişkisi ve eserlerde tercih ettiği ölçek unsurunun mekanların deneyimlenmesi üzerindeki etkisi araştırma sürecine dahil edilmiştir.
Kitap Tasarımına Çağdaş Bir Yaklaşım: Irma Boom
Authors: Tanyel Başar Çiğdem
Published: June 2021

Yüzyıllar boyunca fikirlerin ve kültürlerin aktarımında önemli rol oynayan kitaplar; günümüzün dijitalleşen yapısı ile birlikte geçmiş, şimdi ve gelecek ile bağlantı kurma konusunda önemli bir iletişim aracıdır. Kitabın bizlere ne anlattığının yanı sıra tasarımı da titiz bir araştırma, incelik ve özen isteyen bir alandır. Zaman içerisinde kitap tasarımı da teknolojik gelişmelerin ışığında farklılaşmış ve deneyselliğe daha açık hale gelmiştir. Bu anlamda kitapların çağdaş tasarım anlayışıyla yorumlanmasında Hollandalı grafik tasarımcı Irma Boom’un çalışmaları dikkat çekmektedir. Sanatçı, çağdaş kitap tasarımlarına cesur deneysel yaklaşımlar sergileyerek, basılı içeriğin geleneksel ve bilindik yapısının dışına çıkarak alanında özgün eserler ortaya koymaktadır. Bu araştırmanın amacı, kitap tasarımı alanında uzmanlaşan ve bu alanın ilerlemesine yönelik önemli katkılar sunan sanatçı Irma Boom’un tasarımları aracılığıyla çağdaş kitap tasarımlarının üretim sürecini yansıtmaktır. Nitel desene göre yapılandırılan araştırmada veriler, sanatçının müze arşivlerinde yer alan tasarımlarından, dergi ve gazetelerde yer alan sanatçıya ait haberlerden, sanatçı ile yapılan röportajlardan elde edilmiştir. Elde edilen veriler betimsel olarak yorumlanmıştır.
Features of active longevity of older citizens with different levels of social activity
Authors:   Kursk State Medical University, Nepochatyh Elena
Published: June 2021

The work examines the active longevity of older citizens, which is due to the tendency of the formation of social, medical, legal, public activity of older people. This work reflects the results of the study. The study is presented in a comparative analysis of groups of elderly people aged 68 to 73 years, who adhere to the position of active longevity and citizens who are in social services and do not adhere to social activity.
Chachnama Discourse: The Dichotomy of Islamic Origins in South Asia
Authors:   Professor and Head, Department of Languages, Manipal University Jaipur, Rajasthan, India., Chaudhary Priyanka , Rathore Sara ,   Department of Languages, Manipal University Jaipur, Rajasthan, India.
Published: June 2021

The common narrative of the arrival of Islam in South Asia is shaping contemporary discourse on religious nationalism in the subcontinent. However, this common narrative tends to marginalise the origins of Shias in the region. The study employs the critical theory of New Historicism to trace the historiography of the text in context to the schism among Muslims and discusses the ways in which it participates with only the Sunni origins in the region which are in stark contrast to the Shia origins. Therefore, the paper introspects upon whether Chachnama exclusively a Sunni perspective of the conquest. The findings indicate the marginalisation of Shias in the collective narrative of Muslim origins in South Asia.
Revisioning Subalternity: A critical study of Ramayana through Mandavi and Urmila
Authors:   Research Scholar, Department of Languages, Manipal University Jaipur, Rajasthan, India., Tiwari Aditi , Chaudhary Priyanka
Published: June 2021

Ramayana is a narrative knitted through multiple voices but is written around the story of Rama, neglecting the voices of the minor characters. The contemporary South Asian authors breaking the conventional norms of Ramkatha tradition have provided agency to such characters through their contemporary renderings. The study tries to bring forth such hidden nested narratives of the unheard characters of Mandavi and Urmila who are identified either in relation to Sita or their husbands, to re-define the idea subaltern. The paper will analyse the social and political oppression faced by the two female characters because of the existing gender and power hierarchy existing in the text, the unconscious oppression and suffering neglected by the author, reader and the characters of the text as well. The paper will try to analyse the contemporary renderings as an agency and subaltern space for the voice of these subaltern unsung characters of Ramayana, understanding how the concept of unconscious subaltern and normalization of oppression on these character in the epic, demarcating the related myths.
Revisiting the “Inhabited Space” of English Country House in Sarah Waters’s The Little Stranger
Authors:   Research Scholar, Department of English, Banaras Hindu University., Chowdhury Srijani , Dubey Lata ,   Professor, Department of English, Banaras Hindu University.
Published: June 2021

The English Country House happens to be one of the most iconic topoi in English literary studies. Since narratologists have long privileged time over space, narrative space remained a relatively unexplored territory until the twentieth century, which intensified the interest in the house as the thematic fulcrum of literary works. British novelist Sarah Waters’s first venture into the realm of the sub-genre of English Country House fiction, The Little Stranger (2009) is a befitting discourse that appropriates the poetics of manorial space. Hundreds Hall, the Warwickshire seat of the Ayreses, encapsulates many roles as the epicentre of the story and as a powerful symbol of the gradual decay of English aristocracy in the post-World War II Britain. The article will try to incorporate Gaston Bachelard’s spatial criticism elaborated in his The Poetics of Space (1958) and the concept of heterotopia by Foucault for the interpretation/ (s) of the narrative. The study seeks to locate Bachelard’s bourgeoisie points of view, which the author subverts by portraying the rise of the proletariat. The focus of the article is to highlight the ingenuity of Waters’s creative process, which resorts to the genre of English Country House fiction to capture the condition of British aristocrats in a time of crises.
Empire Style as a Model of the Embodiment of Patriarchal and Orthodox Ideas in European Culture and Music of the Restoration Era
Authors:   Department of Theoretical and Applied Culture, Odessa National A.V. Nezhdanova Academy of Music, Odesa, Ukraine, Muravska Olha V.
Published: June 2021

The article is devoted to the consideration of the qualities of Napoleonic and Alexanderian empire as a “style of empire” and their manifestation in the musical and historical tradition of France and Russia in the first half of the XIX century. The typology of this style is directly associated with the essence of the concept of “empire” as a universal state, pursuing the goals of world domination or leadership and possessing a kind of cultural civilizational mission. For the French absolutism of the New Age and its imperial “hypostasis” in the XIX century, the emphasis on the enlightening and civilizing mission is indicative, while in the history of the Russian Empire, throughout all stages of its existence, the spiritual-messianic idea of understanding Russia as a guardian has been consistently upheld (as “Third Rome”) Orthodoxy inherited from Byzantium. The musical “signs” of the empire became those genre spheres in which the scale of design and ideas were combined with reliance on typical, universally significant means of musical expression, the genesis of which often goes back to the spiritual and religious tradition. The empirical qualities of French musical culture are considered in the example of the poetry of the musical theater of G. Spontini, summarizing the cultural and historical realities of France of the era of the first empire, while the choral polonaises of O. Kozlovsky, which absorbed the sacred genesis and typology of edging, anthem and polonaise, become a sign-symbol of the Alexanderian Empire and its associated imperial court culture.
Cancer Treatments Using Low-Temperature Plasma
Authors: Tanaka Hiromasa , Mizuno Masaaki , Ishikawa Kenji , Toyokuni Shinya , Kajiyama Hiroaki , Kikkawa Fumitaka , Hori Masaru
Published: June 2021

:

Low-temperature plasma (LTP) is a partially ionized gas that contains electrons,
ions, radicals, light, etc. Recently, the bio-medical application of LTP has become
a hot topic in plasma science and biological science. Cancer treatment with plasma is the
most challenging topic in plasma bio-medical applications. Many in vitro and in vivo experiments
have been conducted to investigate the anti-tumor effects of LTP. Extracellular
reactive oxygen and nitrogen species (RONS) in plasma-activated solutions are key factors
for the anti-tumor effects, and amino acid modifications by LTP may affect cellular
responses. Intracellular RONS are also key factors for the anti-tumor effects. Various signaling
pathways, such as p53 signaling pathways, survival and proliferation signaling
pathways, and oxidative stress-dependent signaling pathways are activated by LTP.
Oxypeucedanin is a Mechanism-based Inactivator of CYP2B6 and CYP2D6
Authors: Zhang Kehan , Li Yilin , Fu Yao , Cui Tiantian , Wang Qian , Mao Xu , Peng Ying , Zheng Jiang
Published: June 2021

Background:

Herbal medicine Angelica dahurica is widely employed for the treatment of rheumatism and
pain relief in China. Oxypeucedanin is a major component in the herb.

Objectives :

The objectives of this study are aimed at the investigation of mechanism-based inactivation of CYP2B6
and CYP2D6 by oxypeucedanin, characterization of the reactive metabolites associated with the enzyme inactivation,
and identification of the P450s participating in the bioactivation of oxypeucedanin.

Methods :

Oxypeucedanin was incubated with liver microsomes or recombinant CYPs2B6 and 2D6 under designed
conditions, and the enzyme activities were measured by monitoring the generation of the corresponding products.
The resulting reactive intermediates were trapped with GSH and analyzed by LC-MS/MS.

Results :

Microsomal incubation with oxypeucedanin induced a time-, concentration-, and NADPH-dependent inhibition
of CYPs2B6 and 2D6 with kinetic values of KI/kinact 1.82 μM/0.07 min-1 (CYP2B6) and 8.47 μM/0.044 min-1
(CYP2D6), respectively. Ticlopidine and quinidine attenuated the observed time-dependent enzyme inhibitions. An
epoxide and/or γ-ketoenal intermediate(s) derived from oxypeucedanin was/were trapped in microsomal incubations.
CYP3A4 was the primary enzyme involved in the bioactivation of oxypeucedanin.

Conclusion :

Oxypeucedanin was a mechanism-based inactivator of CYP2B6 and CYP2D6. An epoxide and/or γ-
ketoenal intermediate(s) may be responsible for the inactivation of the two enzymes.
In vitro Clot Lysis Activity of Phenolic Compound Degrading Product From Lignin Sugarcane Baggase Using Ochrobactrum sp.
Authors:   Chemistry departement, Faculty of Mathematics and Natural Science, University of Brawijaya, Srihardyastuti Arie , Farid Rahman Moh ,   Chemistry departement, Faculty of Mathematics and Natural Science, University of Brawijaya, Ardyati Tri ,   Biology departement Faculty of Mathematics and Natural Science, University of Brawijaya, Roosdiana Anna ,   Chemistry departement, Faculty of Mathematics and Natural Science, University of Brawijaya, Prihartini Indah ,   Biotechnology Departement, Univeritas Muhammadiyah Malang
Published: June 2021

Sugarcane bagasse (Saccharum officinarum L) is a readily available waste product of cane sugar processing. The content of lignocelluloses in sugarcane bagasse is approximately 52.7% cellulose, 20% hemicelluloses, and 24.2% lignin. Lignin can be degraded enzymatically by using microorganisms, such as Ochrobactrum sp. Monomer derived from lignin degradation using these bacteria in the optimum condition of sugarcane fermentation (pH 6, temperature 40 °C, for 5 days of incubation, the concentrations of starter 29%) by GC-MS yielded phenolic compounds such as 4-methyl-2, 6-di-tert-butylphenol; 2,6-di-tert-butylquinone; phenol, and p-hydroxybenzaldehide. The thrombolytic activity of these lignin monomers can be tested in-vitro by measuring the ability of clot lysis. Lignin did not have in-vitro clot lysis activity, whereas the lignin monomers in filtrat of fermented sugarcane bagasse have an in-vitro clot lysis activity, although its capacity is not as high as streptokinase.
Assessment of Water Quality in Kuntaur, Central River Region, The Gambia
Authors:   Chemistry Unit, Division of Physical & Natural Sciences, School of Arts & Sciences, University of The Gambia, Oyelakin Oladele , Conteh Mustapha ,   Chemistry Unit, Division of Physical & Natural Sciences, School of Arts & Sciences, University of The Gambia, Iyekowa Osaro ,   Chemistry Unit, Division of Physical & Natural Sciences, School of Arts & Sciences, University of The Gambia,   Department of Chemistry, Faculty of Science, University of Benin, Nigeria, Anthony Adjivon ,   Chemistry Unit, Division of Physical & Natural Sciences, School of Arts & Sciences, University of The Gambia, Mendy Mandalena ,   Chemistry Unit, Division of Physical & Natural Sciences, School of Arts & Sciences, University of The Gambia, Cyril Ntomchukwu Chukwudozie ,   Chemistry Unit, Division of Physical & Natural Sciences, School of Arts & Sciences, University of The Gambia,   College of Medicine, American International University, West-Africa, The Gambia
Published: June 2021

The study deals with twelve water quality parameters on twenty-four sampling locations in Kuntaur. Samples were collected from the both surface water and groundwater. Twelve parameters were: temperature, pH, conductivity, acidity, alkalinity, total dissolved solids, turbidity, iron, nitrite, nitrate, sulphate and phosphorus (orthophosphate). Nearly all the measured parameters fell within the standard reference of the various parameters. The standards were: National Environment Agency, NEA, (The Gambia), World Health Organization, WHO and European Union, EU, Standards.
The Effect of Rhodamine B on The Properties of Fluorescent Nanoparticles Derived from Geothermal Silica
Authors:   Research Centre for Chemistry, Indonesian Institute of Sciences, Maulitiva Untoro Yovilianda , Ayu Widyasari Diaz ,   Department of Chemistry, Faculty of Science and Technology, Universitas Islam Negeri Syarif Hidayatullah Jakarta, Supriadi Edi ,   Research Centre for Chemistry, Indonesian Institute of Sciences, Nurul Aisyiyah Jenie Siti ,   Research Centre for Chemistry, Indonesian Institute of Sciences
Published: June 2021

Rhodamine B can be used as a fluorophore to produce fluorescent silica nanoparticles derived from geothermal sludge. The purpose of this research is to synthesize fluorescent silica nanoparticles (FSNP) modified with rhodamine B and cetyl trimethyl ammonium bromide (CTAB) using sol-gel method. Geothermal waste was used as a precursor and added with NaOH at 900C to generate sodium silicate. Rhodamine B, as the fluorescent dye were added with concentration variations ranging from 0.156 mg/g to 10 mg/g.CTAB was used as template and HCl 2N was applied as gelling catalyst with aging time of 18 hours. Characterization of FSNP was measured using spectrofluorometer to identify the fluorescent intensity, fourier transform infrared (FT-IR) to determine the functional group of FSNP, Brauner-Emmett-Teller (BET) adsorption to calculate the specific area of the particles, X-ray diffraction (XRD) to analyze the crystallographic phases, and transmission electron microscopy (TEM) to analyze the surface morphology of the FSNP. FT-IR and fluorescent intensity results showed that FSNP with 2.5 mg/g of rhodamine B had the optimum characteristics. The FSNP was in amorphous phase with uniform pore distribution. BET analysis showed that the specific surface of the FSNP was 190.22 m2/g.
Simulation of operation of dual-frequency antenna array of GLONASS consumer navigation equipment under influence of simulated interference
Authors: Antonov A. S. , Kapylov E. L.
Published: June 2021

The article deals with the methods of increasing the noise immunity of the navigation equipment of the consumer under the influence of deliberate imitation interference (spoofing). The main differences between imitation interference and powerful noiselike interference are highlighted. The initial data for computer modeling of various signal-interference conditions are formed, with makes it possible to conduct a comparative analysis of various methods of interference suppression. The created model allows us to take into account the real coordinates of navigation satellites relative to the selected observation point, the geometry of the antenna array of the navigation receiver and its main functional characteristics. The possibility of using antenna arrays with a controlled diagram-forming scheme for focusing the radiation pattern in the directional of arrival of satellite navigation signals and creating a «zero» in the direction of arrival of interference is investigate. The dependence of the potential level of interference suppression on the elevation of interference arrival is analyzed. A comparison of two optimization methods used as an interference reduction algorithm is presented.
Methodical approach to estimation of energy characteristics of antenna arrays of space communication means of decimeter wavelengths
Authors: Zvonarev V. V. , Tereschenko S. V. , Brodskiy M. S.
Published: June 2021

The article describes a sequence of mathematical and logical operations for determining the energy and mass-dimensional characteristics of an active phased array antenna operating in the decimeter wavelength range of space communications necessary to ensure continuous operation for a given time. When designing large-size antenna systems, a preliminary assessment of the mass-size, energy and thermal parameters is required to assess the feasibility of the project. In this regard, the article uses a mathematical apparatus that includes a model and methods that allow determining the tactical and technical characteristics of satellite communication systems at the design or development stage. The novelty of the developed method consists in assessing the potential capabilities of spacecraft of satellite communication and retransmission systems, taking into account the energy and weight and size characteristics of their antenna systems and in determining the degree of implementation of the main modes of operation of Earth stations at the design or development stage for the specified operating modes of satellite communication systems.
Distributed detection basis on using soft decision scheme both in local sensors and in fusion center
Authors: Parfenov V. I. , Le V. D.
Published: June 2021

The paper considers distributed detection problem basis on using soft decision scheme both in the local sensors and in the fusion center (FC). The algorithm for making soft decisions when receiving data from local sensors in the fusion center and its performance characteristics, which are necessary for the formation decision fusion rule, are presented. The dependencies of the total error probability on the energy parameter taking into account signal-to-noise ratio at the level of local sensors and the channel’s signal-to-noise ratio are given. The gain of the fusion rule basis on the aggregation of soft decisions in the FC when receiving data about soft local decisions, in efficiency compared to hard fusion rule.
Teleconsultation and the challenges for maintaining health care in times of pandemic
Authors: Tostes Jorge Gelvane , Tostes Carla Benedita da Silva , Cruz Rodrigo Petrim , Souza Vanessa Santos de , Figueiredo Maria das Graças Mota Cruz de Assis , Alves Rosana
Published: June 2021

Telemedicine has proven to be an important tool for the assistance continuity facing the current COVID-19 pandemic. We discussed the role of tele-interconsultation and remote matrix support as resources, within the scope of the Unified Health System, in supporting primary care teams, aiming at maintaining quality and resolution, increasing demand for services, as well as the limitations to their implementation. There are difficulties in access by the population, the need for investment and resistance by professionals and managers. It is still necessary regulation of telemedicine activity in the country, given that the permission by the Federal Council of Medicine occured only during the pandemic. The ability to fill gaps and deficiencies left by specialized services and reference centers stands out, since there is an increase in demand in several areas. In addition, the opportunity for learning, safety in conduct and empowerment of primary care professionals is investigated.
Homelessness, crack use, and length of stay as predictors of planned discharge from night care in a Psychosocial Care Center
Authors: Boska Gabriella de Andrade , Ferreira Rogério da Silva , Claro Heloisa Garcia , Luz Priscilla Oliveira , Oliveira Márcia Aparecida Ferreira de
Published: June 2021

Objective: identify predictors of planned discharge to night care embracement in a Psychosocial Care Center Alcohol and Drugs (CAPS AD III). Methods: Quantitative, retrospective, and documentary study of 560 medical records of people with problems resulting from the use of alcohol and other drugs who were admitted to the hospital at night in a CAPS AD III in São Paulo, over five years. As a dependent variable, the type of discharge was used (planned or not). As independent variables, the profile of the subjects related to substance use and time in hospital. Results: 1,097 admissions were identified with 50.4% of unplanned discharge associated with homelessness (p = 0.007), problematic use crack (p = 0.015), length of reception proposed by the team (p = 0.029) and length of stay of the user (p < 0.001). Conclusion: Being homeless, problematic use of crack, and lack of user participation on the decisions regarding length of stay in CAPS AD III were associated with unplanned discharge.
Multisystem inflammatory syndrome in children associated with COVID-19: nursing care
Authors: Ribeiro Sofia Panato , Boettcher Simone
Published: June 2021

In 2019, a new viral disease, known as SARS-Cov-2 infection, was identified. Scientists believed that it was a disease with low morbidity for pediatric patients; however, a small percentage of children infected with the new coronavirus developed a multisystem inflammatory response, which aroused the interest of many researchers and health professionals. The objective of the study is to describe the main characteristics related to the Pediatric Multisystemic Inflammatory Syndrome Associated with Covid-19 (MIS-C), its complications and nursing care. The main clinical manifestations of MIS-C are hyperthermia, gastrointestinal symptoms, skin manifestations, generalized lymphadenopathy, cardiac and neurological disorders. The main nursing care was listed according to the signs and symptoms, such as monitoring of neurological and hydroelectrolytic changes. The nurse professional must add knowledge about MIS-C so that he is able to qualify his care and improve his skills to provide quality care to pediatric patients.
Rehabilitation games in a world in digital transition
Authors: Fernandes Carla Sílvia
Published: June 2021

Is it possible to analyze the world in the same way, after this globalized and most widespread event of all time? Of course, not; the complexity of this event leads us to the need to address many changes, especially in the health area. Indeed, the pandemic course of COVID-19 has led us to a true digital revolution in such a way that the reality as we know it will be something of the "last century". We live in moments of changing care practices where it is essential to discuss the advantages and potential of other health resources, abandoning a traditionalist view of care. Although the tremendous technological development of the last decades, the health sector is still structured in a historical model of mandatory personal interactions between people and health professionals, that is, in need of face-to-face interaction. Now, the times are of transition, in what can be called hybrid care, functioning as a bridge between the traditional provision of face-to-face care and digital health solutions. These aspects must also be integrated when we think about rehabilitation and its wide range of interventions.
Thrombosis and COVID-19 vaccines
Authors: De Moraes Silva Melissa Andreia , Cristino Mateus Alves Borges , Procópio Ricardo Jayme
Published: June 2021

Vaccines against COVID-19 from Moderna Biotech Spain, SL (COVID-19 Vaccine Moderna – mRNA technology), AstraZeneca (Oxford/Astrazeneca Vaccine - ChAdOx1 - adenovirus vector technology) and Janssen-Cilag International NV (COVID-19 Vaccine) Janssen - Ad.26.COV2.S - adenovirus vector technology) used in Europe, the United States and Brazil has presented severe thrombotic adverse reactions. The recorded thrombosis occurred in unusual sites, such as the sagittal venous sinus.
Формирование наноструктурированных пленок MoS-=SUB=-2-=/SUB=-, WS-=SUB=-2-=/SUB=-, MoO-=SUB=-2-=/SUB=- и гетероструктур на их основе
Authors: Логинов А.Б. , Исмагилов Р.Р. , Бокова-Сирош С.Н. , Божьев И.В. , Образцова Е.Д. , Логинов Б.А. , Образцов А.Н.
Published: June 2021

In this work thin film coatings based on WS2, MoS2, MoO2 and their composites were synthesized, morphological and structural properties of deposited coatings were studied. Chemical vapor deposition with heated MoO3, WO3, S powder as precursors was used. Dependence of structural and morphological properties, chemical composition of deposited films on parameters of synthesis was defined. Films of vertically aligned 10 nm thick plate crystals consisting both of pure MoO2 and MoO2 covered with thin MoS2 layer were obtained. Formation of polycrystalline films of regular triangular shaped WS2 and uniform continuous 20 nm thick WS2 films with covering area of 2x2mm has also been observed. In this work we also report about synthesis of films consisting of regular triangular shaped WS2 crystals and MoS2 irregularly shaped crystals overlapping each other.
Создание функциональных наноструктур под действием ионного облучения
Authors: Приходько К.Е. , Дементьева М.М.
Published: June 2021

The paper describes a method developed in National Research Centre “Kurchatov Institute” for creating different functional nanostructures using ion beam irradiation. As an example, the formation of an integrated resistive elements in a low-temperature NbN superconductor nanowire is demonstrated. The possibility of producing an insulating layer of aluminum oxide with a thickness of 15 nm on the aluminum surface at room temperature under 0.2 keV oxygen ions irradiation was shown.
Линзовый корректор волнового фронта для изучения плоских поверхностей
Authors: Торопов М.Н. , Ахсахалян А.А. , Малышев И.В. , Михайленко М.С. , Пестов А.Е. , Салащенко Н.Н. , Чернышов А.К. , Чхало Н.И.
Published: June 2021

The method of manufacturing and the results of studies of a lens corrector that converts a spherical diverging front into a plane one and is intended for studying flat surfaces as part of an interferometer with a diffraction comparison wave is described. A feature of the corrector is the use of an aspherical convex surface with a maximum deviation of ∼200 μm from the nearest sphere. The first experimental results are presented, indicating the prospects for using ion-beam processing to improve the quality of the wavefront. After the procedure of ion-beam processing, the aberrations over the entire aperture of the corrector decreased by more than 4 times and amounted to the parameter of the height difference PV = 207 nm (∼λ/3) and RMS = 19.2 nm (∼λ /33). On an area with a diameter of 80%, the aberrations fell to the nanometer level: PV = 65 nm (∼λ/10) and RMS = 8.3 nm (∼λ/76).
Cuantificación de bacterias nitrificantes en un suelo Typic melanudands en tres condiciones de uso de suelo en Pasto, Nariño, Colombia
Authors: Culchac Cuaran Lubi Yomaira , Estrada Marcillo Jhon Sebastián , Ordóñez Jurado Héctor Ramiro
Published: June 2021

El presente estudio se realizó en el municipio de Pasto (Nariño, Colombia), con el fin de estimar la cantidad de bacterias oxidadoras de amonio (BOA) y bacterias oxidadoras de nitrito (BON), en tres usos del suelo (bosque secundario, pastura tradicional y sistema silvopastoril) a dos profundidades (0-10 y 10-20 cm). Para ello, se utilizó un diseño experimental completamente al azar (DCA), con seis tratamientos y tres repeticiones, para un total de 18 unidades experimentales; para su estimación, se utilizó la técnica del número más probable (NMP). El análisis de varianza mostró diferencias estadísticas altamente significativas para usos y profundidades del suelo en BOA. La pastura tradicional presentó la mayor densidad de BOA a una profundidad de 0-10 cm: 8,8 × 104 UFC/g, y el bosque presentó menor densidad: 1,3 × 103 UFC/g. En BON, la mayor densidad poblacional se encontró en pastura: 9,4 × 103 UFC/g, y el bosque presentó menor densidad: 3,8 × 103 UFC/g. La mayor densidad de bacterias se presentó de 0 a 10 cm en BOA: 3,7 × 103 UFC/g, mientras que para BON fue de 7,3 × 103 UFC/g, debido posiblemente a que en los primeros 5 cm del suelo se encuentra la capa biológicamente más activa. Las mayores densidades de bacterias nitrificantes encontradas en los usos de suelo: pastura tradicional y sistema silvopastoril, pudieron estar relacionadas con las fertilizaciones orgánicas, reincorporación del estiércol y orina de los animales, que son un sustrato ureico promotor de crecimiento de microorganismos.
Alignment of Key Stakeholders’ Priorities for Patient-Facing Tools in Digital Health: Mixed Methods Study
Authors: Lyles Courtney Rees , Adler-Milstein Julia , Thao Crishyashi , Lisker Sarah , Nouri Sarah , Sarkar Urmimala
Published: June 2021

Background

There is widespread agreement on the promise of patient-facing digital health tools to transform health care. Yet, few tools are in widespread use or have documented clinical effectiveness.

Objective

The aim of this study was to gain insight into the gap between the potential of patient-facing digital health tools and real-world uptake.

Methods

We interviewed and surveyed experts (in total, n=24) across key digital health stakeholder groups—venture capitalists, digital health companies, payers, and health care system providers or leaders—guided by the Consolidated Framework for Implementation Research.

Results

Our findings revealed that external policy, regulatory demands, internal organizational workflow, and integration needs often take priority over patient needs and patient preferences for digital health tools, which lowers patient acceptance rates. We discovered alignment, across all 4 stakeholder groups, in the desire to engage both patients and frontline health care providers in broader dissemination and evaluation of digital health tools. However, major areas of misalignment between stakeholder groups have stymied the progress of digital health tool uptake—venture capitalists and companies focused on external policy and regulatory demands, while payers and providers focused on internal organizational workflow and integration needs.

Conclusions

Misalignment of the priorities of digital health companies and their funders with those of providers and payers requires direct attention to improve uptake of patient-facing digital health tools and platforms.
Substandard and Falsified Medicines: Proposed Methods for Case Finding and Sentinel Surveillance
Authors: Pisani Elizabeth , Hasnida Amalia , Rahmi Mawaddati , Kok Maarten Olivier , Harsono Steven , Anggriani Yusi
Published: June 2021

The World Health Organization and others warn that substandard and falsified medicines harm health and waste money, especially in low- and middle-income countries. However, no country has measured the market-wide extent of the problem, and no standardized methods exist to estimate the prevalence of either substandard or falsified medicines. This is, in part, because the task seems overwhelming; medicine markets are huge and diverse, and testing medicines is expensive. Many countries do operate some form of postmarket surveillance of medicine, but their methods and goals differ. There is currently no clear guidance on which surveillance method is most appropriate to meet specific public health goals. In this viewpoint, we aimed to discuss the utility of both case finding and risk-based sentinel surveillance for substandard and falsified medicines, linking each to specific public health goals. We posit that choosing the system most appropriate to the goal, as well as implementing it with a clear understanding of the factors driving the production and sale of substandard and falsified medicines, will allow for surveillance resources to be concentrated most efficiently. We adapted principles used for disease outbreak responses to suggest a case-finding system that uses secondary data to flag poor-quality medicines, proposing risk-based indicators that differ for substandard and falsified medicines. This system potentially offers a cost-effective way of identifying “cases” for market withdrawal, enhanced oversight, or another immediate response. We further proposed a risk-based sentinel surveillance system that concentrates resources on measuring the prevalence of substandard and falsified medicines in the risk clusters where they are most likely to be found. The sentinel surveillance system provides base data for a transparent, spreadsheet-based model for estimating the national prevalence of substandard and falsified medicines. The methods we proposed are based on ongoing work in Indonesia, a large and diverse middle-income country currently aiming to achieve universal health coverage. Both the case finding and the sentinel surveillance system are designed to be adaptable to other resource-constrained settings.
Mobile Technology Access and Use Among Adolescent Mothers in Lima, Peru: Mixed Methods Study
Authors: Levey Elizabeth J , Onyeaka Henry , Bartles Sophia M , Sanchez Calderon Elena , Sanchez Sixto E , Prom Maria C , Fesseha Eden M , Gelaye Bizu
Published: June 2021

Background

Research shows promise for the use of mobile health interventions to improve access to care for mothers and infants. Although adolescent mothers in particular are comfortable with technology and often face barriers to accessing care, data on the use of digital interventions with young mothers are limited.

Objective

This study aims to examine technology access and use behavior among adolescent mothers in Lima, Peru, to inform the development of technology-mediated perinatal interventions for high-risk mothers and infants in low- and middle-income countries and other areas with limited access to care.

Methods

This mixed methods study consisted of a phone survey about technology access (N=29), focus group discussions with clinicians (N=25), and semistructured in-depth interviews with adolescent mothers (N=10) and their family members (N=8) in Lima.

Results

All adolescent mothers surveyed had access to a smartphone, and nearly half had access to a computer or tablet. However, participants reported a number of obstacles to consistent smartphone access related to the financial precarity of their situations. Examples of this included difficulty affording phone services, using shared plans, and losing smartphones because of theft.

Conclusions

These findings indicate that adolescent mothers are connected to technology, highlighting the potential scalability of technology-based health interventions for adolescent mothers in low- and middle-income countries while identifying barriers that need to be addressed.