bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychosocial oral health‐related quality of life impact: A systematic review
Authors: Su Naichuan , van Wijk Arjen , Visscher Corine M.
Published: August 2020

Background

Psychosocial wellbeing is an important determinant for patients' oral health‐related quality of life (OHRQoL). Psychosocial impact (PI), together with the dimensions Oral Function, Orofacial Pain and Orofacial Appearance, has been proposed to cover the different areas of OHRQoL.

Objective

The objective of the study was to collect further scientific support for the new four‐dimensional structure of OHRQoL. This study is one out of a series of four and focuses on the PI in patients with dental anxiety, oral cancer and periodontitis (PROSPERO registration number: CRD42017064033).

Methods

Five databases (Pubmed (Medline), EMBASE, Cochrane, CINAHL and PsycINFO) were electronically searched on 8 June 2017 and updated on 14 January 2019, to identify the studies that measure OHRQoL using the Oral Health Impact Profile (OHIP) for oral health conditions. In this review, studies were included if the mean/median domain scores from OHIP‐14 or OHIP‐49 were available for patients with dental anxiety, oral cancer or periodontitis. The score of the handicap domain from the OHIP was used to assess patients` PI. The handicap domain includes 6 items for OHIP‐49 with a domain score ranging from 0 to 24 and 2 items for OHIP‐14 with a domain score ranging from 0 to 8. For comparison between the 2 versions of the OHIP, the domain score of OHIP‐49 was conversed into a 0 to 8 metric. The domain scores of the included studies were then pooled, separately for each of the included dental disorders.

Results

A total of 2104 records were identified based on the search strategy. After screening of titles and abstracts, 1607 articles were reviewed in full text. Twenty‐three articles met the inclusion criteria for this review and were included in the study. The 23 articles contained 3884 patients, grouped in 30 patient populations and 42 patient samples. The pooled mean scores of PI for dental anxiety, oral cancer and periodontitis were 3.2, 1.9 and 0.8, respectively, on the 0 to 8 metric.

Conclusion

This review provides standardised information about the OHRQoL impact for three dental disorders as a model for the PI dimension. Dental anxiety tends to show the strongest effect on the PI dimension, while periodontitis tends to show the weakest effect on the PI dimension. Future studies need to confirm whether the reported differences in PI scores between the three dental disorders are statistically significant.
Effect of membrane integrity on survival competition of Botrytis cinerea upon QoI fungicide pyraclostrobin
Authors: Xiong Hui , Liu Xuefeng , Fan Yuhang , Luan Shaorong , Huang Qingchun
Published: August 2020

Botrytis cinerea, the causal agent of the grey mould disease, developed resistance to multiple fungicides. However, the role of cell membrane in survival competition of B. cinerea upon quinone outside inhibitor (QoI) fungicide has not yet been elucidated. In this paper, the enhancement of cystamine, a transglutaminase inhibitor, on membrane integrity of B. cinerea was determined, and the effect of the enhancement on the sensitivity of B. cinerea to pyraclostrobin was investigated. The results showed that pyraclostrobin inhibited mycelial growth with EC50 as 1.122 and 3.042 μg/ml at 24 and 48 hr, respectively. In the treatment of 5 and 50 μg/ml pyraclostrobin, membrane integrity of B. cinerea was broken, causing high permeability, lipid peroxidation, flocculent and malformed surface with vague septum and abundant agglomerates inside and outside the mycelia. Cystamine even at 50 and 200 μg/ml had little inhibitory effect on mycelial growth. However, in presence of 50 or 200 μg/ml cystamine, the mycelia from pyraclostrobin treatment possessed a significantly reduced leakage, lower MDA content, and a revived fibrous and transparent surface. Meanwhile, SEM images showed that membrane integrity of the mycelia was significantly improved and the agglomerates were dramatically disappeared. Synergy assays further revealed that B. cinerea regained less sensitivity to pyraclostrobin inhibition. In conclusion, membrane integrity controls mycelia sensitivity and is required for survival competition of B. cinerea upon pyraclostrobin.
Efficacy of oral torasemide in dogs with degenerative mitral valve disease and new onset congestive heart failure: TheCARPODIEMstudy
Authors: Besche Beatrice , Blondel Thomas , Guillot Emilie , Garelli‐Paar Catherine , Oyama Mark A.
Published: August 2020

Background

Torasemide is a potent loop diuretic with potential to treat congestive heart failure (CHF) in dogs.

Objective

Evaluate the efficacy and safety of torasemide compared to furosemide in dogs with first occurrence of CHF caused by degenerative mitral valve disease (DMVD).

Animals

Three hundred and nineteen dogs with new onset CHF attributable to DMVD.

Methods

Double‐blinded randomized noninferiority study of PO torasemide vs furosemide in addition to standard CHF treatment. The primary efficacy criterion was decreased pulmonary edema and cough and no worsening of dyspnea or exercise tolerance at day 14. Secondary endpoints included clinical response at day 84 and time to death, euthanasia, or premature study withdrawal for cardiac reasons.

Results

Torasemide q24h (n = 161) was noninferior to furosemide q12h (n = 158); percentage of dogs meeting primary efficacy criterion at day 14 was similar between groups (torasemide, 74.4% [95% confidence interval (CI), 66.8%‐81.0%] vs. furosemide, 73.5% [95% CI, 65.7%‐80.4%]; risk ratio [RR], 1.01; 95% CI, 0.89‐1.15;P= .87). Efficacy at day 84 showed similar results (RR, 1.05; 95% CI, 0.88‐1.25;P= .6). Dogs receiving torasemide had a longer time to endpoint and were less than half as likely to experience death, euthanasia, or premature study withdrawal (hazard ratio, 0.36; 95% CI, 0.19‐0.65;P= .001) than dogs receiving furosemide at any time during the study.

Conclusion and Clinical importance

Torasemide was noninferior to furosemide as first line PO treatment for new onset CHF caused by DMVD. Torasemide significantly decreased risk of cardiac‐related death or premature study withdrawal for cardiac reasons compared to furosemide.
A phosphoinositide 5‐phosphatase from Solanum tuberosum is activated by PAMP‐treatment and may antagonize phosphatidylinositol 4,5‐bisphosphate at Phytophthora infestans infection sites
Authors: Rausche Juliane , Stenzel Irene , Stauder Ron , Fratini Marta , Trujillo Marco , Heilmann Ingo , Rosahl Sabine
Published: August 2020

Potato (Solanum tuberosum) plants susceptible to late blight disease caused by the oomycete Phytophthora infestans display enhanced resistance upon infiltration with the pathogen‐associated molecular pattern (PAMP), Pep‐13. Here, we characterize a potato gene similar to Arabidopsis 5‐phosphatases which was identified in transcript arrays performed to identify Pep‐13 regulated genes, and termed StIPP.

Recombinant StIPP protein specifically dephosphorylated the D5‐position of phosphatidylinositol 4,5‐bisphosphate (PtdIns(4,5)P2) in vitro. Other phosphoinositides or soluble inositolpolyphosphates were not converted.

When transiently expressed in tobacco (Nicotiana tabacum) pollen tubes, a StIPP‐YFP fusion localized to the subapical plasma membrane and antagonized PtdIns(4,5)P2‐dependent effects on cell morphology, indicating in vivo functionality. Phytophthora infestans‐infection of N. benthamiana leaf epidermis cells resulted in relocalization of StIPP‐GFP from the plasma membrane to the extra‐haustorial membrane (EHM). Colocalizion with the effector protein RFP‐AvrBlb2 at infection sites is consistent with a role of StIPP in the plant–oomycete interaction. Correlation analysis of fluorescence distributions of StIPP‐GFP and biosensors for PtdIns(4,5)P2 or phosphatidylinositol 4‐phosphate (PtdIns4P) indicate StIPP activity predominantly at the EHM.

In Arabidopsis protoplasts, expression of StIPP resulted in the stabilization of the PAMP receptor, FLAGELLIN‐SENSITIVE 2, indicating that StIPP may act as a PAMP‐induced and localized antagonist of PtdIns(4,5)P2‐dependent processes during plant immunity.
Automated labeling of schematic maps by optimization with knowledge acquired from existing maps
Authors: Lan Tian , Li Zhilin , Peng Qian , Gong Xinyu
Published: August 2020

Schematic maps are simplified representations of line networks, aiming to help people quickly and accurately perform route planning and orientation tasks. The automated generation of such maps is generally treated as an optimization problem. Most researchers prefer to optimize network layouts and name labels separately, because optimizing them simultaneously is still intractable. It is found that optimizing network layouts is extensively studied, while optimizing name labels is rarely considered. In the optimization of name labels, constraints can be established with rules from cartographic experts, literature (e.g., specification and technical documents), and/or existing maps. However, some rules from experts and literature cannot be explicitly and mathematically expressed. This study aims to develop an automated labeling method with rules from existing maps. We first acquire the rules (i.e., the potential positions and the preferences of these positions) from some existing schematic maps and then integrate them into an optimization algorithm. Experimental evaluation is conducted by a questionnaire in terms of “ease level of finding name labels,” “congestion level,” and “satisfaction level” using Tianjin and Hong Kong metro schematic maps and the labels of our method. The results show that the proposed method can automatically generate effective labels.
Numerical Modeling of a Photovoltaic/Microchannel Direct-Expansion Evaporator for a CO2 Heat Pump
Authors: Uddin Rony Rajib , Adam Gladen
Published: August 2020

A numerical model of a PV/microchannel direct-expansion evaporator for a CO2 heat pump is developed and validated with experimental data from the literature. The effects of degree of superheating, CO2 mass flux, and evaporation temperature on the amount of heat absorbed, pressure drop in the microchannel evaporator, PV temperature, and electrical efficiency are analyzed. The analysis shows that increasing the degree of superheating decreases the amount of heat absorbed, has minimal effect on the PV temperature (for superheating <15 °C), but reduces the pressure drop. The variation of CO2 mass flux has a minimal effect on the amount of heat absorbed and the PV temperature, but the pressure drop increases with increasing CO2 mass flux. Increasing the evaporation temperature decreases the amount of heat absorbed, reduces the pressure drop, and increases the PV temperature. For average ambient conditions for Fargo, North Dakota, a 5–10 °C of superheating at the evaporator outlet, an evaporator temperature between −5 and +5 °C, and a CO2 mass flux of 330–550 kg · m−2 · s−1 balance maximizing the heat absorption while minimizing the pressure drop. To maximize the PV efficiency, lower evaporation temperatures should be used. At an evaporation temperature of 0 °C and an insolation level of 1000 W · m−2, the CO2 microchannel evaporator causes a 23 °C reduction in PV panel temperature which corresponds to a 1.44% absolute increase in PV efficiency.
Experimental Investigation of Heat Transfer on the Internal Tip Wall in a Rotating Two-Pass Rectangular Channel
Authors: Chia Kai-Chieh , Huang Szu-Chi , Liu Yao-Hsien
Published: August 2020

The tip turn region within the gas turbine blade experienced severe thermal issues related to temperature variations and temperature gradients. The current study experimentally measured the heat transfer distribution of the internal blade tip wall in a rotating cooling channel. The aspect ratio of this rectangular channel was 1:4, and the hydraulic diameter was 25.6 mm. Due to the impact of the 180 deg turn, complex three-dimensional flow significantly affected the heat transfer on the internal tip surface. The steady-state liquid crystal method was used to obtain a detailed distribution of heat transfer on the internal tip surface. In this study, the leading and trailing surfaces of the channel wall were either smooth or roughened with 45 deg angled ribs. The Reynolds number inside the pressurized cooling channel ranged from 10,000 to 30,000, and the rotation number was up to 0.53. Furthermore, two-channel orientations (90 deg and 135 deg) with respect to the rotation direction were tested. The tip heat transfer from the smooth channel wall was more sensitive to rotation, and the largest heat transfer enhancement caused by rotation was 68%. Channel orientation of 90 deg produced higher heat transfer compared to the orientation of 135 deg.
Experimental Validation of a Robust H∞ Control Method on Miniaturized Optical Image Stabilizer Prototypes
Authors: Alizadegan Alireza , Zhao Pan , Nagamune Ryozo , Chiao Mu
Published: August 2020

This paper validates a robust H∞ controller design method, experimentally, on miniaturized prototypes of the magnetically actuated lens-tilting optical image stabilizers (OISs) with product variabilities. Five small-scale OIS prototypes with product variations are constructed by three-dimensional (3D) printing. For the prototypes, the model parameters are identified based on experimental frequency response data of the prototypes. Using the identified model, a robust H∞ controller is designed to guarantee the robust stability of the closed-loop system and to optimize the closed-loop performance. The experimental results reveal larger and more complex uncertainties in miniaturized OISs with mass-produced parts compared to large-scale prototypes. Despite the increased amount of uncertainties, it is demonstrated that the robust H∞ controller still outperforms the conventional controllers in terms of robust closed-loop stability, performance, and controller order for practical implementation on a mobile phone device.
Deletion of a Peptidylprolyl Isomerase Gene Results in the Inability of
Caldicellulosiruptor bescii
To Grow on Crystalline Cellulose without Affecting Protein Glycosylation or Growth on Soluble Substrates
Authors: Russell Jordan F. , Russo Matthew L. , Wang Xuewen , Hengge Neal , Chung Daehwan , Wells Lance , Bomble Yannick J. , Westpheling Janet
Published: August 2020

Caldicellulosiruptor
has the ability to digest complex plant biomass without pretreatment and have been engineered to convert biomass, a sustainable, carbon neutral substrate, to fuels. Their strategy for deconstructing plant cell walls relies on an interesting class of cellulases consisting of multiple catalytic modules connected by linker regions and carbohydrate binding modules. The best studied of these enzymes, CelA, has a unique deconstruction mechanism. CelA is located in a cluster of genes that likely allows for optimal expression, secretion, and activity. One of the genes in this cluster is a putative isomerase that modifies the CelA protein. In higher eukaryotes, these isomerases are essential for the proper folding of glycoproteins in the endoplasmic reticulum, but little is known about the role of isomerization in cellulase activity. We show that the stability and activity of CelA is dependent on the activity of this isomerase.
Critical COVID-19 patient evacuation on an amphibious assault ship: feasibility and safety. A case series
Authors: Nguyen Cédric , Montcriol A , Janvier F , Cungi P-J , Esnault P , Mathais Q , Vallet C , Boussen S , Cordier P-Y , Serpin L , Papazian L , Bordes J
Published: August 2020

Introduction

An amphibious assault ship was deployed on 22 March in Corsica to carry out medical evacuation of 12 critical patients infected with COVID-19. The ship has on-board hospital capacity and is the first time that an amphibious assault ship is engaged in this particular condition. The aim is to evaluate the feasibility and safety of prolonged medical evacuation of critical patients with COVID-19.

Methods

We included 12 patients with confirmed COVID-19 infection: six ventilated patients with acute respiratory distress syndrome and six non-ventilated patients with hypoxaemia. Transfer on an amphibious assault ship lasted 20 hours. We collected patients’ medical records: age, comorbidities, COVID-19 history and diagnosis, ventilation supply and ventilator settings, and blood gas results. We calculated oxygen consumption (OC).

Results

All patients had a medical history. The median delay from onset of symptoms to hospitalisation was 8 (7–10) days. The median Sequential Organ Failure Assessment score on admission was 3 (2–5). There was no significant increase in oxygen during ship transport and no major respiratory complication. There was no significant increase in arterial oxygen pressure to fractional inspired oxygen ratio among ventilated patients during ship transport. Among ventilated patients, the median calculated OC was 255 L (222–281) by hours and 5270 L (4908–5616) during all ship transport. Among non-ventilated patients, the median calculated OC was 120 L (120–480) by hours and 2400 L (2400–9600) during all ship transport.

Conclusion

The present work contributes to assessing the feasibility and safety condition of critical COVID-19 evacuation on an amphibious assault ship during an extended transport. The ship needs to prepare a plan and a specialised intensive team and conduct patient screening for prolonged interhospital transfers.
Value of FEops HEARTguide patient-specific computational simulations in the planning of left atrial appendage closure with the Amplatzer Amulet closure device: rationale and design of the PREDICT-LAA study
Authors: Garot Philippe , Iriart Xavier , Aminian Adel , Kefer Joelle , Freixa Xavier , Cruz-Gonzalez Ignacio , Berti Sergio , Rosseel Liesbeth , Ibrahim Reda , Korsholm Kasper , Odenstedt Jacob , Nielsen-Kudsk Jens-Erik , Saw Jaqueline , Sondergaard Lars , De Backer Ole
Published: August 2020

Background

Optimal preprocedural planning is essential to ensure successful device closure of the left atrial appendage (LAA).

Design

The PREDICT-LAA study is a prospective, international, multicentre, randomised controlled trial (ClinicalTrials.govNCT04180605). Two hundred patients eligible for LAA closure with an Amplatzer Amulet device (Abbott, USA) will be enrolled in the study. Patients will be allocated to a computational simulation arm (experimental) or standard treatment arm (control) using a 1:1 randomisation. For patients randomised to the computational simulation arm, preprocedural planning will be based on the analysis of cardiac computed tomography (CCT)-based patient-specific computational simulations (FEops HEARTguide, Ghent, Belgium) in order to predict optimal device size and position. For patients in the control arm, preprocedural planning will be based on local practice including CCT analysis. The LAA closure procedure and postprocedural antithrombotic therapy will follow local practice in both arms. The primary endpoint of the study is incomplete LAA closure and device-related thrombus as assessed at 3 months postprocedural CCT. Secondary endpoints encompass procedural efficiency (number of devices used, number of repositioning, procedural time, radiation exposure, contrast dye), procedure-related complications within 7 days postprocedure and a composite of all-cause death and thromboembolic events at 12 months.

Conclusion

The objective of the PREDICT-LAA study is to test the hypothesis that a preprocedural planning for LAA closure with the Amplatzer Amulet device based on patient-specific computational simulations can result in a more efficient procedure, optimised procedural outcomes and better clinical outcomes as compared with a standard preprocedural planning.

Trial registration number

ClinicalTrials.gov Registry (NCT04180605).
Combined treatment of menadione and calcitriol increases the antiproliferative effect by promoting oxidative/nitrosative stress, mitochondrial dysfunction, and autophagy in breast cancer MCF-7 cells
Authors: Guizzardi Solange , Picotto Gabriela , Rodriguez Valeria , Welsh JoEllen , Narvaez Carmen , Bohl Luciana , Tolosa de Talamoni Nori
Published: August 2020

The aim of this study was to determine new insights into the molecular mechanisms involved in the antiproliferative action of menadione + calcitriol (MEN+D) on MCF-7 cells. After 24 h, MEN+D inhibited the cell growth but was not observed with each single treatment. The combined drugs reduced the mitochondrial respiration at that time, as judged by an increase in the proton leak and a decrease in the ATP generation and coupling efficiency. At longer times, 48 or 96 h, either D or MEN reduced the proliferation, but the effect was higher when both drugs were used together. The combined treatment increased the superoxide anion ([Formula: see text]) and nitric oxide (NO•) contents as well as acidic vesicular organelles (AVOs) formation. The percentage of cells showing the lower mitochondrial membrane potential (ΔΨm) was highly increased by the combined therapy. LC3-II protein expression was enhanced by any treatment. In conclusion, the antiproliferative action of MEN+D involves oxidative/nitrosative stress, mitochondrial alteration, and autophagy. This combined therapy could be useful to treat breast cancer cells because it inhibits multiple oncogenic pathways more effectively than each single agent.
Extending trinity to the scalar sector through discrete flavoured symmetries
Authors: Alves João M. , Botella Francisco J. , Branco Gustavo C. , Nebot Miguel
Published: August 2020

We conjecture the existence of a relation between elementary scalars and fermions, making it plausible the existence of three Higgs doublets. We introduce a Trinity Principle (TP) which, given the fact that there are no massless quarks, requires the existence of a minimum of three Higgs doublets. The TP states that each row of the mass matrix of a quark of a given charge should receive the contribution from one and only one scalar doublet and furthermore a given scalar doublet should contribute to one and only one row of the mass matrix of a quark of a given charge. This principle is analogous to the Natural Flavour Conservation (NFC) of Glashow and Weinberg with the key distinction that NFC required the introduction of a flavour blind symmetry, while the TP requires a flavoured symmetry, to be implemented in a natural way. We provide two examples which satisfy the Trinity Principle based on $${\mathbb {Z}}_3$$Z3 and $${\mathbb {Z}}_2\times {\mathbb {Z}}_2'$$Z2×Z2′ flavoured symmetries, and show that they are the minimal multi-Higgs extensions of the Standard Model where CP can be imposed as a symmetry of the full Lagrangian and broken by the vacuum, without requiring soft-breaking terms. We show that the vacuum phases are sufficient to generate a complex CKM matrix, in agreement with experiment. The above mentioned flavoured symmetries lead to a strong reduction in the number of parameters in the Yukawa interactions, enabling a control of the Scalar Flavour Changing Neutral Couplings (SFCNC). We analyse some of the other physical implications of the two models, including an estimate of the enhancement of the Baryon Asymmetry of the Universe provided by the new sources of CP violation, and a discussion of the strength of their tree-level SFCNC.
Unitarity bound violation in holography and the instability toward the charge density wave
Authors: Song Geunho , Seo Yunseok , Sin Sang-Jin
Published: August 2020

We study the spectral function of holographic fermions with Pauli term. We find the [Formula: see text]-dependent instability signaled by the tachyonic spectrum ([Formula: see text]-gap) from the [Formula: see text] regime where unitarity is violated. We suggest that this is the instability toward the charge density wave (CDW) based on the similarity of the unitarity violation in conformal field theory (CFT) and the nesting Fermi surface phenomena in weakly interaction system: both of them give divergent enhancement of degree of freedom.
Differential and difference equations for recurrence coefficients of orthogonal polynomials with hypergeometric weights and Bäcklund transformations of the sixth Painlevé equation
Authors: Hu Jie , Filipuk Galina , Chen Yang
Published: August 2020

It is known from [G. Filipuk and W. Van Assche, Discrete orthogonal polynomials with hypergeometric weights and Painlevé VI, Symmetry Integr. Geom. Methods Appl. 14 (2018), Article ID: 088, 19 pp.] that the recurrence coefficients of discrete orthogonal polynomials on the nonnegative integers with hypergeometric weights satisfy a system of nonlinear difference equations. There is also a connection to the solutions of the [Formula: see text]-form of the sixth Painlevé equation (one of the parameters of the weights being the independent variable in the differential equation) [G. Filipuk and W. Van Assche, Discrete orthogonal polynomials with hypergeometric weights and Painlevé VI, Symmetry Integr. Geom. Methods Appl. 14 (2018), Article ID: 088, 19 pp.]. In this paper, we derive a second-order nonlinear difference equation from the system and present explicit formulas showing how this difference equation arises from the Bäcklund transformations of the sixth Painlevé equation. We also present an alternative way to derive the connection between the recurrence coefficients and the solutions of the sixth Painlevé equation.
Fractional Hadamard and Fejér-Hadamard Inequalities Associated with Exponentially s,m-Convex Functions
Authors: Guo Shuya , Chu Yu-Ming , Farid Ghulam , Mehmood Sajid , Nazeer Waqas
Published: August 2020

The aim of this paper is to present the fractional Hadamard and Fejér-Hadamard inequalities for exponentially s,m-convex functions. To establish these inequalities, we will utilize generalized fractional integral operators containing the Mittag-Leffler function in their kernels via a monotone function. The presented results in particular contain a number of fractional Hadamard and Fejér-Hadamard inequalities for s-convex, m-convex, s,m-convex, exponentially convex, exponentially s-convex, and convex functions.
Finite-State-Space Truncations for Infinite Quasi-Birth-Death Processes
Authors: Baumann Hendrik
Published: August 2020

For dealing numerically with the infinite-state-space Markov chains, a truncation of the state space is inevitable, that is, an approximation by a finite-state-space Markov chain has to be performed. In this paper, we consider level-dependent quasi-birth-death processes, and we focus on the computation of stationary expectations. In previous literature, efficient methods for computing approximations to these characteristics have been suggested and established. These methods rely on truncating the process at some level N, and for N⟶∞, convergence of the approximation to the desired characteristic is guaranteed. This paper’s main goal is to quantify the speed of convergence. Under the assumption of an f-modulated drift condition, we derive terms for a lower bound and an upper bound on stationary expectations which converge quickly to the same value and which can be efficiently computed.
The Utilization of Complementary and Alternative Medicine among Saudi Older Adults: A Population‐Based Study
Authors: Aljawadi Mohammad H. , Khoja Abdullah T. , AlOtaibi Azzam D. , Alharbi Khalid Turki , Alodayni Muhannad Abdulwahed , AlMetwazi Mansour S. , Arafah Azher , Al-Shammari Sulaiman A. , Khoja Tawfik A.
Published: August 2020

Background. Complementary and alternative medicine (CAM) is an integral part of patients′ therapeutic experience worldwide. Among Saudi older adults, less is known about CAM utilization. Objectives. To determine the prevalence, patterns, and factors associated with CAM utilization among SOA. Methods. In the Saudi National Survey for Elderly Health (SNSEH), subjects were asked about CAM use during the last twelve months before the interview. CAM use was defined as any use of herbal products, acupuncture, bloodletting, cauterization, medical massage, bones manual manipulation, honey, or religious rituals. Demographic characteristics included gender, age, marital status, region, educational level, and residence area. In addition, multiple comorbidities were included as possible factors that may be associated with CAM use. Multivariable logistic regression was used to explore factors associated with CAM utilization. All statistical analyses were done using STATA v.14. Results. Out of 2946 respondents, 50.4% were males, the mean age was 70.3 ± 8.3 years, and 70% were illiterate. CAM use was prevalent (62.5%). The most common CAM types were herbal products (25.4%), acupuncture (21.2%), bloodletting (12%), honey (9.5%), cauterization (7.4%), medical massage and bones manual manipulation (4%), and traditional bone setting (2.1%). In the multivariable regression, age, gender, and marital status did not have an impact on the odds of using CAM. Subjects from rural areas were 2.92 times more likely to use CAM compared with subjects in urban areas (OR = 2.92; 95%CI: 2.28‐3.75). Subjects with metabolic disorders (OR = 0.50; 95% CI: 0.42‐0.60) or kidney disease were less likely to use CAM (OR = 0.30; 95%CI: 0.14‐0.64). About pain, CAM is used more in neck pain (OR = 1.69; 95%CI: 1.30‐2.21) and also used in back pain (OR =  1.22; 95%CI: 1.03‐1.46). Conclusions. CAM use was very prevalent among SOA. Clinicians and pharmacists must ask about CAM use among older adults as many of CAM may interact with patients medications.
In Vivo Imaging of Hypoxia and Neoangiogenesis in Experimental Syngeneic Hepatocellular Carcinoma Tumor Model Using Positron Emission Tomography
Authors: Kis Adrienn , Szabó Judit P. , Dénes Noémi , Vágner Adrienn , Nagy Gábor , Garai Ildikó , Fekete Anikó , Szikra Dezső , Hajdu István , Matolay Orsolya , Méhes Gábor , Mező Gábor , Kertész István , Trencsényi György
Published: August 2020

Introduction. Hypoxia‐induced ανβ3 integrin and aminopeptidase N (APN/CD13) receptor expression play an important role in tumor neoangiogenesis. APN/CD13‐specific 68Ga‐NOTA‐c(NGR), ανβ3 integrin‐specific 68Ga‐NODAGA‐[c(RGD)]2, and hypoxia‐specific 68Ga‐DOTA‐nitroimidazole enable the in vivo detection of the neoangiogenic process and the hypoxic regions in the tumor mass using positron emission tomography (PET) imaging. The aim of this study was to evaluate whether 68Ga‐NOTA‐c(NGR) and 68Ga‐DOTA‐nitroimidazole allow the in vivo noninvasive detection of the temporal changes of APN/CD13 expression and hypoxia in experimental He/De tumors using positron emission tomography. Materials and Methods. 5 × 106 hepatocellular carcinoma (He/De) cells were used for the induction of a subcutaneous tumor model in Fischer‐344 rats. He/De tumor‐bearing animals were anaesthetized, and 90 min after intravenous injection of 10.2 ± 1.1 MBq 68Ga‐NOTA‐c(NGR) or 68Ga‐NODAGA‐[c(RGD)]2 (as angiogenesis tracers) or 68Ga‐DOTA‐nitroimidazole (for hypoxia imaging), whole‐body PET/MRI scans were performed. Results. Hypoxic regions and angiogenic markers (αvβ3 integrin and APN/CD13) were determined using 68Ga‐NOTA‐c(NGR), 68Ga‐DOTA‐nitroimidazole, and 68Ga‐NODAGA‐[c(RGD)]2 in subcutaneously growing He/De tumors in rats. 68Ga‐NOTA‐c(NGR) showed the strong APN/CD13 positivity of He/De tumors in vivo, by which observation was confirmed by western blot analysis. By the qualitative analysis of PET images, heterogenous accumulation was found inside He/De tumors using all radiotracers. Significantly (p ≤ 0.01) higher SUVmean and SUVmax values were found in the radiotracer avid regions of the tumors than those of the nonavid areas using hypoxia and angiogenesis‐specific radiopharmaceuticals. Furthermore, a strong correlation was found between the presence of angiogenic markers, the appearance of hypoxic regions, and the tumor volume using noninvasive in vivo PET imaging. Conclusion. 68Ga‐DOTA‐nitroimidazole and 68Ga‐NOTA‐c(NGR) are suitable diagnostic radiotracers for the detection of the temporal changes of hypoxic areas and neoangiogenic molecule (CD13) expression, which vary during tumor growth in a hepatocellular carcinoma model.
Multispectral Remote Sensing Utilization for Monitoring Chlorophyll-a Levels in Inland Water Bodies in Jordan
Authors: Hussein Nidal M. , Assaf Mohammed N.
Published: August 2020

This study focuses on the utilization of multispectral satellite images for remote water-quality evaluation of inland water body in Jordan. The geophysical parameters based on water’s optical properties, due to the presence of optically active constituents, are used to determine contaminant level in water. It has a great potential to be employed for continuous and cost-effective water-quality monitoring and leads to a reliable regularly updated tool for better water sector management. Three sets of water samples were collected from three different dams in Jordan. Chl-a concentration of the water samples was measured and used with corresponding Sentinel 2 surface reflectance (SR) data to develop a predictive model. Chl-a concentrations and corresponding SR data were used to calibrate and validate different models. The predictive capability of each of the investigated models was determined in terms of determination coefficient (R2) and lowest root mean square error (RMSE) values. For the investigated sites, the B3/B2 (green/blue bands) model and the Ln (B3/B2) model showed the best overall predictive capability of all models with the highest R2 and the lowest RMSE values of (0.859, 0.824) and (30.756 mg/m3, 29.787 mg/m3), respectively. The outcome of this study on selected sites can be expanded for future work to cover more sites in the future and ultimately cover all sites in Jordan.
AdipoRon Protects against Tubular Injury in Diabetic Nephropathy by Inhibiting Endoplasmic Reticulum Stress
Authors: Xiong Shan , Han Yachun , Gao Peng , Zhao Hao , Jiang Na , Sun Lin
Published: August 2020

Endoplasmic reticulum (ER) stress has been reported to play a pivotal role in diabetic nephropathy (DN). AdipoRon is a newly developed adiponectin receptor agonist that provides beneficial effects for diabetic mice; however, its underlying mechanism remains to be delineated. Here, we demonstrated increased expression levels of ER stress markers, accompanied by upregulated levels of proinflammatory cytokines and increased expression of collagen I, fibronectin, Bax, and cleaved caspase 3 in the kidneys of db/db mice compared with control mice. Decreased expression of adiponectin receptor 1 (AdipoR1) and phosphorylated 5′AMP-activated kinase (p-AMPK) was also observed in the kidneys of db/db mice. However, these alterations were partially reversed by intragastric gavage with AdipoRon. In vitro, AdipoRon alleviated high-glucose-induced ER stress, oxidative stress, and apoptosis in HK-2 cells, a human tubular cell line. Moreover, AdipoRon restored the expression of AdipoR1 and p-AMPK in HK-2 cells exposed to high-glucose conditions. Additionally, these effects were partially abrogated by pretreatment with AdipoR1 siRNA, but this abrogation was ameliorated by cotreatment with AICAR, an AMPK activator. Furthermore, the effects of AdipoRon were also partially abolished by cotreatment with compound C. Together, these results suggest that AdipoRon exerts favorable effects on diabetes-induced tubular injury in DN by inhibiting ER stress mediated by the AdipoR1/p-AMPK pathway.
Changing Trends in Firework-Related Eye Injuries in Southern China: A 5-Year Retrospective Study of 468 Cases
Authors: Wang Fangyu , Lou Bingsheng , Jiang Zhaoxin , Yang Yao , Ma Xinqi , Lin Xiaofeng
Published: August 2020

Firework-related eye injury is a horrible medical problem and creates huge health and social burdens. Herein, we explored the changing trends and demographic and clinical features of firework-related eye injury, in an effort to inform strategies to prevent this injury. We reviewed the data of 468 hospitalized patients who underwent surgery for firework-related eye injury at the Zhongshan Ophthalmic Center between January 2013 and December 2017. During this period, the trend in firework-related eye injuries was stable (mean, 93 ± 14 cases per year), and fireworks were the major cause of explosive eye injury. The average age of the patients was 24 ± 18 years and 87% of the patients were male, with boys under 10 years of age comprising the largest group (27% of patients). There were an average of 24 ± 7 cases per year from urban areas and 70 ± 8 cases from rural areas (P<0.05). Furthermore, 21 ± 5% of cases occurred during Spring Festival. After treatment, the best corrected visual acuity was increased compared to that before treatment, and the intraocular pressure tended to become normal by the final visit (P<0.05). The top three diagnoses were cataract (39%), retinal detachment (18%), and choroidal detachment (14%). Additionally, the most common surgery was cataract extraction (25%), followed by pars plana vitrectomy (19%) and pars plana vitrectomy plus pars plana lensectomy (10%). Over the five-year study period, day surgery hospitalization increased from 1% to 32%. This was associated with a corresponding decrease in the length of hospitalization, without adverse events, demonstrating that day surgery is feasible in firework-related eye injury cases. The present study results suggest that greater attention should be paid to firework-related eye injury, and a variety of measures should be taken to prevent this kind of ocular tragedy.
Magnitude, Severity, and Associated Factors of Anemia among Under-Five Children Attending Hawassa University Teaching and Referral Hospital, Hawassa, Southern Ethiopia, 2016
Authors: Gebereselassie Yeshimebet , BirhanSelassie Mesganaw , Menjetta Tadesse , Alemu Jemal , Tsegaye Aster
Published: August 2020

Background. Anemia is a widespread public health problem associated with increased risk of morbidity and mortality. Infants, under-5-year-old children, and pregnant women have greater susceptibility to anemia. The magnitude and associated risk factors for anemia vary in different settings. The study aimed to assess the magnitude, severity, and associated factors of anemia at Hawassa University Teaching and Referral hospital, Hawassa, southern Ethiopia. Methods. In a hospital-based cross-sectional study, a total of 422 under-five children were included. Sociodemographic data and other predisposing factors were collected by structured questionnaire. Venous blood samples were collected and analyzed for hemoglobin determination using a Cell-Dyn 1800 automated analyzer. Stool samples were collected and processed using direct wet mount and formol-ether concentration method to detect intestinal parasites. Data were entered and analyzed using SPSS version 20 statistical packages. Binary and multiple logistic regressions were computed to assess factors associated with anemia. p value less than 0.05 was taken as statistically significant. Result. The overall prevalence of anemia was found to be 41.7%. The mean hemoglobin level was 10.59 g/dl. Anemia was of mild, moderate, and severe type in 6.6%, 19%, and 16.1% of the children, respectively. Children in the age group 6–23 months (AOR = 2.04 (95% CI: 1.13, 3.69)), and mothers having no formal education (AOR = 1.73 (95% CI: 0.99, 3.02)) were identified as associated factors for anemia. Conclusion. The prevalence of anemia among the study subjects was 41.7% indicative of the fact that anemia is an important public health problem. It was associated with the child’s age, residence, mother’s education level, and intestinal parasite (Ascaris lumbricoides). It clearly indicates that there should be well integrated public health interventions to improve the health status that needs to be prioritized to prevent anemia among children under five years of age.
An Automatic Recognition Method of Microseismic Signals Based on S Transformation and Improved Gaussian Mixture Model
Authors: Wang Kaikai , Tang Chun’an , Ma Ke , Wang Xintang , Li Qiang
Published: August 2020

The microseismic signals in the coal minefield are very complex because of its special environment with a large number of blast vibration signals, and how to effectively identify the microseismic signals is still a big problem. S transform (ST) and Manifold Learning (ML) methods are introduced to extract the characteristics of the microseismic signals, and Gaussian Mixture Model based on the improved Bee Colony optimization algorithm (IBC‐GMM) is established to identify the microseismic signals accurately. Firstly, the time‐frequency characteristics of microseismic signals in coal mine are extracted by ST analysis. It is found that there are obvious time‐frequency differences between rock‐fracturing signals and blast vibration signals. Blast vibration signals have short duration, high frequency, and complex frequency spectrum, and their dominant frequencies are mainly over 100 Hz. However, rock‐fracturing signals are relatively slow, with low frequency and stable spectrum change, and their dominant frequencies are generally below 100 Hz. Then, combining with the microseismic data of Xiashinjie coal mine in Tongchuan, China, the feature dimension reduction is carried out by Manifold Learning (ML) method, and the processed feature vectors are automatically recognized by IBC‐GMM. Field test results show that the method summarizes the characteristics of the microseismic wave which are difficult to emerge as the learning vector, and the features reflect the key features of microseismic signals well. The identification accuracy is as high as 94%, and its recognition effect is superior to other recognition models (such as traditional Gaussian Mixture Model based on Expectation‐Maximum (EM‐GMM), Backpropagation (BP) neural network, Random Forests (RF), Bayes (Bayes) methods, and Logistic Regression (LR) method). Therefore, IBC‐GMM could be used to mine engineering microseismic monitoring waveform recognition to provide the reference.
Risk Factors for Co-Twin Fetal Demise following Radiofrequency Ablation in Multifetal Monochorionic Gestations
Authors: Gabby Lauryn C. , Chon Andrew H. , Korst Lisa M. , Llanes Arlyn , Chmait Ramen H.
Published: August 2020

Background: Umbilical cord occlusion via radiofrequency ablation (RFA) is utilized to maximize outcomes of the co-twin in complicated multifetal monochorionic (MC) gestations. However, post-procedure co-twin fetal demise is of concern. Objective: The aim of this study was to determine risk factors for co-twin fetal demise following RFA. Methods: This is a retrospective study of MC multiples that underwent RFA. Indications for RFA included twin reversed arterial perfusion (TRAP) sequence, selective fetal growth restriction (sFGR) type II, discordant lethal anomalies, and twin-twin transfusion syndrome (TTTS) with proximate placental cord insertion sites. The primary outcome was co-twin fetal demise. Bivariate analyses and multiple logistic regression modeling of identified risk factors were conducted. Results: Of 36 patients studied, surgical indications were: TRAP (n = 15, 41.7%), sFGR (n = 10, 27.8%), discordant anomalies (n = 9, 25.0%), and TTTS (n = 2, 5.6%). Nine patients (25.0%) experienced a co-twin fetal demise. In multiple logistic regression analysis, fetal growth restriction (FGR) of one co-twin was associated with increased risk of co-twin fetal demise (OR = 10.85, 95% CI 1.03–114.48, p = 0.0474) and a preoperative diagnosis of TRAP was protective against fetal demise (OR = 0.06, 95% CI 0.00–0.84, p = 0.0368). Conclusion: Co-twin FGR was associated with an increased risk of post-RFA demise. When compared to other indications, patients with TRAP sequence were less likely to have a co-twin demise.
Ações de uma empresa júnior em fonoaudiologia voltadas à comunidade coralística
Authors: Alpes Matheus Francoy , Henriques Carla Regina Chaves , Ricci Gabriela Lima , Wolf Aline Epiphanio
Published: August 2020

A Empresa Júnior tem o objetivo de proporcionar aos alunos a possibilidade de colocar em prática os conteúdos teóricos aprendidos durante a graduação e difundir os conhecimentos e possibilidades de atuação para seu público-alvo. A Empresa Júnior em Fonoaudiologia da FMRP-USP foi fundada em 2011, e as ações fonoaudiológicas voltadas à comunidade coralística abordadas neste relato foram realizadas em 2013. Como ação, foi ministrada uma palestra informativa sobre higiene vocal, fisiologia e anatomia das estruturas para a produção vocal e o uso da voz, e a avaliação e a orientação fonoaudiológica específica eram disponibilizadas aos integrantes do coral interessados, posteriormente. A Empresa desenvolve projetos de diversas temáticas até os dias atuais e tem evidenciado constante crescimento e reconhecimento dentro e fora do campus.
Como (não) ler o romance policial: o caso Agatha Christie
Authors: Chauvin Jean Pierre
Published: August 2020

Este artigo defende um novo lugar para o romance policial, tendo em vista as qualidades intrínsecas desse gênero literário. A abordagem focaliza duas obras célebres de Agatha Christie: Assassinato no Expresso do Oriente (1934) e Poirot Perde uma Cliente (1937). Analisar as personagens e narradores que a autora criou constitui método seguro para interpretações mais produtivas, que permitem ao investigador revalorizar a ficção detetivesca, discutir o papel dos best-sellers: obras que estimulam a leitura e a permanência do gênero policial no âmbito da cultura.
Visual Indeterminacy in GAN Art
Authors: Hertzmann Aaron
Published: August 2020

This paper explores visual indeterminacy as a description for artwork created with Generative Adversarial Networks (GANs). Visual indeterminacy describes images that appear to depict real scenes, but on closer examination, defy coherent spatial interpretation. GAN models seem to be predisposed to producing indeterminate images, and indeterminacy is a key feature of much modern representational art, as well as most GAN art. The author hypothesizes that indeterminacy is a consequence of a powerful-but-imperfect image synthesis model that must combine general classes of objects, scenes and textures.
Notes on taxonomy and distribution of some Palaearctic Ancylosis Zeller, 1839 (Lepidoptera: Pyralidae: Phycitinae)
Authors: BIDZILYA OLEKSIY , BUDASHKIN YURIY , SLAMKA FRANTIŠEK , TSVETKOV EUGENE , YEPISHIN VIKTOR
Published: August 2020

The taxonomy of several Ancylosis species is revised. Four new synonyms are established: Ancylosis brunneonervella Roesler, 1970 syn. nov. of Ancylosis albicosta (Staudinger, 1870); Ancylosis psammicola (Roesler, 1970) syn. nov. of Ancylosis leucocephala (Staudinger, 1879); Ancylosis unicolorella (Roesler, 1970) syn. nov. of Ancylosis pallida (Staudinger, 1870). The following taxa are re-instated as separate species: Ancylosis delicatella (Möschler, 1860) spec. rev., stat. nov. and Ancylosis ciliatella (Zeller, 1872) spec. rev., stat. nov. are taken out from synonymy with Ancylosis rhodochrella (Herrich-Schäffer, 1852); Ancylosis deliciosella (Caradja, 1910) spec. rev., stat. nov. is taken out from synonymy with Ancylosis hellenica (Staudinger, 1870); Ancylosis macedonica (Schawerda, 1937) spec. rev., stat. nov. is taken out from synonymy with Ancylosis muliebris (Meyrick, 1937). Heterographis costalbella Amsel, 1954—the junior homonym of Heterographis costalbella Mabille, 1906, is taken out from synonymy with Ancylosis syrtella (Ragonot, 1887) and re-instated as separate species under replacement name Ancylosis amseli Yepishin, 2020 nom. nov. Ancylosis ciliella (Amsel, 1961) syn. nov. is transferred from synonymy with A. rhodochrella to synonymy with A. delicatella. Female genitalia of A. amseli and A. delicatella as well as male genitalia of A. deliciosella and genitalia of both sexes of A. ciliatella are described for the first time. Ancylosis deliciosella is recorded as new for Iran, A. delicatella—for Azerbaijan and Kazakhstan, Ancylosis rhodochrella (Herrich-Schäffer, 1852)—for Georgia, Ancylosis larissae Bidzilya, Budashkin & Yepishin, 2019—for Russia, Kazakhstan, Iran, Afghanistan, Mongolia and China, and Ancylosis yerburii (Butler, 1884) is new for Russia and Kazakhstan.