bluuebunny/crossref_metadata_2025 huggingface dataset:
Frequency of watching television, owning a mobile phone and risk of being overweight/obese among reproductive-aged women in low- and lower-middle-income countries: A pooled analysis from Demographic and Health Survey data
Authors: Ahammed Benojir , Haque Rezwanul , Rahman Syed Mahbubur , Keramat Syed Afroz , Mahbub Afrin , Ferdausi Farzana , Alam Khorshed
Published: May 2022

People who are overweight and obese suffer from significant health impacts that have increased globally. Concurrently, usage of information and communication devices such as television and mobile phones have also been growing, affecting people’s weight. This study examined the association between watching television and owning a mobile phone with overweight and obesity among reproductive-aged women in low- and lower-middle-income countries (LLMICs). Data of 21 LLMICs reported between 2015 and 2020 were collected from the Demographic and Health Surveys. Multivariate logistic regression was performed to determine the association into three pooled segments: a group of 21 countries, the World Bank income classification and the regional categorisation of the countries. The all-inclusive prevalence of overweight or obesity was found at 27.1% among 175,370 reproductive-aged women, and this prevalence varied among countries. Overall, the odds of being overweight or obese were 1.20 (adjusted odds ratio [AOR]=1.20, 95% confidence interval [CI]: 1.15–1.24), 1.40 (AOR=1.40, 95% CI: 1.35–1.44) and 1.18 (AOR=1.18, 95% CI: 1.03–1.35) times higher among those who watched television less than once a week, at least once a week and almost every day, respectively, compared with those who did not watch television. Besides, women’s mobile phone ownership is more likely to experience overweight or obesity (AOR=1.72, 95% CI: 1.67–1.77). Consistent results were found for the countries categorised according to the World Bank income and regional classification. Focus on sedentary behaviour, such as television watching and mobile phone use, of women and regional or country-specific innovative strategies and programs are of great immediate importance to decrease the prevalence of overweight and obesity.
Six-canal video head impulse test in patients with labyrinthine and retrolabyrinthine pathology: detecting vestibulo-ocular reflex deficits
Authors: Kontorinis G , Tailor H , Tikka T , Slim M A M
Published: May 2022

Background

Abnormal gains in six-canal video head impulse test are attributed to semi-circular canal deficits. However, as video head impulse test responses are linked to the vestibulo-ocular reflex, it was hypothesised that abnormal gains can be caused by vestibulo-ocular reflex pathway deficits.

Methods

This study compared video head impulse test gains in 20 patients with superior semi-circular canal dehiscence (labyrinthine cause) and 20 side- and gender-matched patients with vestibular schwannomas (retrolabyrinthine cause), and investigated correlations between them (Mann–Kendall trend test).

Results

Vestibular schwannoma but not superior semi-circular canal dehiscence was significantly associated with abnormal lateral (odds ratio = 9.00 (95 per cent confidence interval = 1.638–49.44), p = 0.011) and posterior (odds ratio = 9.00 (95 per cent confidence interval = 2.151–37.659), p = 0.003) canal status. In vestibular schwannoma patients, there was a statistically significant degree of dependence between all ipsilesional canal video head impulse test gains; such dependence was not observed in superior semi-circular canal dehiscence.

Conclusion

Vestibulo-ocular reflex gains differ in patients with labyrinthine and retrolabyrinthine disease; this suggests that abnormal gains can indicate deficits not only in the semi-circular canals but also elsewhere along the vestibulo-ocular reflex pathway.
Surface waves in a streaming plasma propagating in a duct: kinetic theory
Authors: Lee Hee J. , Cho Sang-Hoon
Published: May 2022

The dispersion relation of a surface wave generated by a drifting plasma in an infinite duct surrounded by vacuum is derived non-relativistically by means of the Vlasov equation. The kinematic boundary condition imposed on the distribution function, the specular reflection conditions on the four sides of duct, can be satisfied by placing an infinite number of fictitious surface charge sheets spaced by the duct widths. The surface wave mode is specifically the transverse magnetic mode, often called the surface polariton, which propagates with phasor

$\exp ({{\rm i}k_zz-{\rm i}\omega t})$

. The method of placing appropriate fictitious surface charge sheets enables one to treat the surface waves in semi-infinite, slab and duct plasmas simultaneously on an equal footing, kinetically. The streaming effect manifests itself through the Doppler-shifted frequency and a correction-like term

${u^2}/{c^2}$

, where u is the streaming velocity and c is the speed of light.
Nobodies and Somebodies: Embodying Precarity on the Early Modern English Stage
Authors: Burkert Mattie
Published: May 2022

Stock characters named “Nobody” and “Somebody” were mainstays of British performance culture in the mid- to late eighteenth century. Playbills and newspaper advertisements show that these roles were popular with audiences in London, Dublin, and Edinburgh, as well as on the regional stages. Men and women alike took on these personae to deliver songs, prologues, and epilogues, often as part of benefit performances where they chose their most crowd-pleasing roles to maximize ticket sales. Some of the pieces spoken by Nobody and Somebody were popular enough to make their way into print, excerpted in novels and miscellanies. The duo appeared in George Alexander Stevens's wildly popular Lecture on Heads (1764), which traveled across the Atlantic to stages in Charleston, Philadelphia, and New York, continuing to be performed in the early Republic until the nineteenth century. Offstage, the figures were staples of visual culture; as Terry Robinson has shown, audience awareness of these figures from Romantic-era political cartoons formed an important backdrop for Mary Robinson's theatrical afterpiece Nobody (1794).
The Roads Not Taken: Liberty, Sovereignty and the Idea of the Republic in Poland-Lithuania and the British Isles, 1550–1660
Authors: Frost Robert
Published: May 2022

In the mid-sixteenth century, there were many parallels between the political cultures of Poland-Lithuania and the kingdoms of the British Isles, as thinkers inspired by the ideals of Renaissance civic humanism challenged traditional currents of thought. Across the British Isles and Poland-Lithuania there were strong native traditions asserting the liberties of communities of the realm and the need to check unbridled royal authority through parliamentary assemblies. As the Reformation swept across the British Isles and Poland-Lithuania, traditional claims concerning the right to resist tyrannical authority were bolstered. Finally, in 1603, Scotland and England formed a loose political union as Poland and Lithuania had formed a loose political union in 1386, although it was not until 1707 that England and Scotland followed the example of the 1569 Lublin Union, when Poland and Lithuania established the first parliamentary union in European history. Despite these parallels, the fates of these composite polities were very different, and their political cultures diverged substantially. This article considers the idea of the Renaissance republic in Poland-Lithuania and the British Isles. It suggests why their roads diverged, and asks what made all the difference.
How do teachers of primary school approach the music assessment in Chile? Differences and similarities between professors’ experience and ministerial guidelines
Authors: Sepúlveda-Ortega Andrea , Magnitzky-Vargas David
Published: May 2022

This research reflects the considerations of music teachers when assessing their students, the tools used and their consistency with guidelines issued by the Chilean Ministry of Education, along with theoretical approaches to assessment. In this way, we have analysed the theoretical contribution of renowned scholars such as Pujol, Santos Guerra, Chacón, and Fautley, as well as the music curricula of the Ministry of Education from first to eighth grade. We propose that it is essential to understand the experience of teachers in the assessment process from a constructivist perspective, analysing their agreement or disagreement with the current ministerial theoretical foundations in relation to assessment.
Investigating how composing teaching and assessment in English secondary school classrooms reinforce myths about composers and their creative practices
Authors: Devaney Kirsty
Published: May 2022

Although composing has been a significant part of formal classroom music education in England for over 30 years, there still remains uncertainty about how to teach and assess composing in secondary schools. This research investigates the under-researched area of teaching and learning of composing in upper secondary schools in England whereby students (aged 14–18) may opt to study music for a national qualification. Taking a mixed methodology approach, data were collected through a survey of 182 music teachers, interviews with five prominent composer-educators, as well as research with five case study schools involving observations of teaching and interviews with teachers and students. This paper reports on three prominent beliefs about composers that seem to underpin teaching and assessment practices; firstly that composers have innate musical talents; secondly that composing is solely an individual process and finally that students must learn the ‘rules’ of composing before being creative. This article proposes that these perceptions do not reflect the diversity of composers’ creative practices and may result in reinforcing stereotypes and myths about composers that have the potential to disadvantage certain students in the examination.
Lightly-harvested rustic cocoa is a valuable land cover for amphibian and reptile conservation in human-modified rainforest landscapes
Authors: Cervantes-López Martín de Jesús , Andresen Ellen , Hernández-Ordóñez Omar , Mora Francisco , Reynoso Víctor Hugo , Arroyo-Rodríguez Víctor
Published: May 2022

The conservation of tropical biodiversity depends not only on forest remnants, but also on anthropogenic land covers. Some shade crops are considered wildlife-friendly agroecosystems, but their conservation value is context- and taxon-dependent. Amphibians and reptiles have received less attention despite their high sensitivity to habitat disturbance. We determined the conservation value of lightly-harvested rustic cocoa plantations for herpetofauna in the Lacandona region, Mexico. We compared 12 environmental variables between habitats. Then, we compared the abundance, species number and composition of amphibian and reptile assemblages. Within each habitat, we explored the relationships between environmental variables and abundance and species number. Tree density, litter cover and litter depth were higher in cocoa. Abundance of reptiles and amphibians were higher in cocoa than forest; species number did not differ. Habitat explained some of the variation (8%) in assemblage composition. In cocoa, amphibian abundance was positively related to canopy height and the presence of a humus layer, while reptile abundance was negatively related to relative humidity. We conclude that lightly-used rustic cocoa plantations can be suitable habitat for forest herpetofauna. As long as cocoa plantations do not replace existing forest cover, they can play an important role in the design of wildlife-friendly tropical landscapes.
Groups generated by two twists along spherical sequences
Authors: VOLKOV Y.
Published: May 2022

We describe all groups that can be generated by two twists along spherical sequences in an enhanced triangulated category. It will be shown that with one exception such a group is isomorphic to an abelian group generated by not more than two elements, the free group on two generators or the braid group of one of the types
$A_2$
,
$B_2$
and
$G_2$
factorised by a central subgroup. The last mentioned subgroup can be nontrivial only if some specific linear relation between length and sphericity holds. The mentioned exception can occur when one has two spherical sequences of length 3 and sphericity 2. In this case the group generated by the corresponding two spherical twists can be isomorphic to the nontrivial central extension of the symmetric group on three elements by the infinite cyclic group. Also we will apply this result to give a presentation of the derived Picard group of selfinjective algebras of the type
$D_4$
with torsion 3 by generators and relations.
“Innocent Young Girls”: The Search for Female Provincial Leaders in China
Authors: Chen Minglu
Published: May 2022

There are few women among China's local political leadership. Current scholarship on the topic co-locates women's political participation with the representation of other marginalized social groups. In particular, it is argued that female politicians are simply tokenistic representatives of the marginalized: female, intellectual, ethnic minority and non-Communist Party members. An examination of those women who have served in provincial leadership positions over the last two terms suggests that such a characterization is misleading. Rather, the evidence indicates that women have been appointed on the same grounds as male leaders in terms of age, education, CCP membership and experience. Gender disparities in the selection of provincial leaders are in fact considerably more nuanced and can be traced to the lack of institutionalized policies and processes as well as women's ongoing disadvantages in education, political networks and training.
Efficacy of different presentation modes for L2 video comprehension: Full versus partial display of verbal and nonverbal input
Authors: Chi Chen , Chen Hao-Jan Howard , Tseng Wen-Ta , Liu Yeu-Ting
Published: May 2022

Video materials require learners to manage concurrent verbal and pictorial processing. To facilitate second language (L2) learners’ video comprehension, the amount of presented information should thus be compatible with human beings’ finite cognitive capacity. In light of this, the current study explored whether a reduction in multimodal comprehension scaffolding would lead to better L2 comprehension gain when viewing captioned videos and, if so, which type of reduction (verbal vs. nonverbal) is more beneficial. A total of 62 L2 learners of English were randomly assigned to one of the following viewing conditions: (1) full captions + animation, (2) full captions + static key frames, (3) partial captions + animation, and (4) partial captions + static key frames. They then completed a comprehension test and cognitive load questionnaire. The results showed that while viewing the video with reduced nonverbal visual information (static key frames), the participants had well-rounded performance in all aspects of comprehension. However, their local comprehension (extraction of details) was particularly enhanced after viewing a key-framed video with full captions. Notably, this gain in local comprehension was not as manifest after viewing animated video content with full captions. The qualitative data also revealed that although animation may provide a perceptually stimulating viewing experience, its transient feature most likely taxed the participants’ attention, thus impacting their comprehension outcomes. These findings underscore the benefit of a reduction in nonverbal input and the interplay between verbal and nonverbal input. The findings are discussed in relation to the use of verbal and nonverbal input for different pedagogical purposes.
The health of detainees and the role of primary care: Position paper of the European Forum for Primary Care
Authors: Groenewegen Peter , Dirkzwager Anja , van Dam Anke , Massalimova Dina , Sirdifield Coral , Smith Lauren
Published: May 2022

This position paper aims to increase awareness among primary care practitioners and policymakers about the specific and complex health needs of people who experience incarceration. We focus on the importance of primary care and of continuity of care between prison and community. We highlight what is known from the literature on the health of people who experience incarceration, on the organisation of prison health care, and on the role of primary care both during and after detention. We present three case descriptions of detainees’ encounters with the organisation of prison health care in three European countries. Finally, we describe the position that the European Forum for Primary Care takes. Prisoners and ex-prisoners have a worse physical and mental health compared with a cross-section of the population. However, access to good quality treatment and care is often worse than in the outside situation. In particular, well-organised primary care in the prison context could benefit prisoners and, indirectly, society at large. Moreover, continuity of care between the community and the prison situation needs improvement.
Can regime change improve ethnic relations? Perception of ethnic minorities after the 2021 coup in Myanmar
Authors: David Roman , Myat Aung Kaung , Holliday Ian
Published: May 2022

Regime change often exacerbates ethnic conflict. This article examines the curious case of Myanmar, where a 2021 military coup was met, on the surface, with broad-based resistance across a divided society. An important question that therefore arises is whether, below the surface, this unity also took a more positive form of national solidarity. Were deep ethnic cleavages intensified or alleviated by the 2021 coup? This question bears theoretical relevance for the study of ethnic conflict and has social relevance for a nation marked by a long history of civil war and a recent experience of genocide against Rohingya Muslims. The article engages in a systematic examination of 180 social media posts uploaded in Burmese by key opinion leaders both before and after the coup. A qualitative analysis of major positive and negative themes indicates a shift in attitudes. The quantitative analysis shows that ethnic relations, measured by a change in themes, ratings and virality, improved significantly in the immediate aftermath of Myanmar's 2021 coup.
Feminist Governance in the European Parliament: The Political Struggle over the Inclusion of Gender in the EU’s COVID-19 Response
Authors: Elomäki Anna , Kantola Johanna
Published: May 2022

The research objective of this article is to analyze the European Parliament’s response to the COVID-19 pandemic from the perspective of feminist governance. Feminist governance can either play a role in ensuring the inclusion of a gender perspective in crisis responses, or, quite the opposite, crises may weaken or sideline feminist governance. The empirical analysis focuses on two aspects of feminist governance: (1) a dedicated gender equality body and (2) gender mainstreaming. In addition to assessing the effectiveness of feminist governance, the analysis sheds light on the political struggles behind the policy positions. The article argues that feminist governance in the European Parliament was successful in inserting a gender perspective into the COVID-19 response. The article pinpoints the effects of the achievements of the European Parliament’s Women’s Rights and Gender Equality Committee and gender mainstreaming on gendering the pandemic crisis response.
A remote cognitive behavioural therapy approach to treating hoarding disorder in an older adult
Authors: Malone Aoife , McCormack David , McCullough Emma
Published: May 2022

Hoarding disorder (HD) is characterised by excessive acquisition and distress associated with discarding objects, resulting in significant clutter. At present, cognitive behavioural therapy (CBT) represents the strongest evidence base for treating HD, although some limitations exist. Little research has examined the effectiveness of remote-CBT interventions for HD in older adults. This case study focuses on Mary, an older female adult presenting with clinically significant hoarding behaviours which severely impact her daily functioning and quality of life. Assessment and intervention followed a structured CBT approach. Despite the complicating factor of COVID-19, Mary responded well to a remote-CBT intervention, with progress indicators suggesting modest improvements in personal, social and occupational functioning. These findings support the use of remote-CBT for HD in both reducing frequency and intensity of hoarding behaviours and improving wellbeing.

Key learning aims

(1)

Hoarding disorder (HD) is a poorly understood disorder that can significantly impact an individual’s personal, social and occupational functioning.

(2)

According to a cognitive behavioural model, HD emanates from information-processing deficits, emotional attachment difficulties, behavioural avoidance and maladaptive beliefs about objects and the self (Frost and Hartl, 1996).

(3)

Observations from this case study suggest the acceptability and effectiveness of a remote cognitive behavioural therapy (CBT) intervention for HD, with outcomes appearing congruous with those produced by face-to-face intervention.

(4)

While research attests to the effectiveness of a CBT intervention for HD, an augmented account of the mechanisms through which these outcomes are achieved is required.
Supporting the Right to Wear Religious Symbols: The Importance of Perceived Commitment to the Nation
Authors: Scott Colin
Published: May 2022

Understanding the social dynamics of public opposition to religious symbols is a pressing issue. This research finds that stereotypes of how committed group members are to the national community shape support for the right to wear religious symbols in various settings. These social perceptions are particularly influential in determining support for the rights of Muslims to wear religious symbols. Drawing on data from a national survey experiment (N = 974) conducted in Canada, the results show Christians benefit from a particularly strong perceived commitment to the nation, while religious minorities are stereotyped as less committed and identified to the country than the average Canadian. As the perceived national commitment of religious minorities increases, however, the gap in support shown for the rights of Christians over religious minorities disappears and may lead to particularly strong support for the rights of Muslims to wear religious symbols in public when perceptions of national commitment are high.
Approaches to Discrimination Claims: A Comparison of the Administrative Tribunals of the Asian Development Bank and the Inter-American Development Bank Group
Authors: TREBILCOCK Anne
Published: May 2022

This article examines the approaches taken by the Asian Development Bank Administrative Tribunal and the Administrative Tribunal of the Inter-American Development Bank Group in deciding discrimination claims. The article reviews the basic features of each tribunal before examining their jurisprudence on equality of treatment and issues of information disclosure in discrimination cases. Decisions to date have addressed claims of disparate treatment relating to various aspects of remuneration and benefits as well as allegations of arbitrary treatment vis-à-vis others similarly situated. A few cases have involved allegations of discrimination on the basis of sex/gender, one of several protected grounds in equality law. The number of judicial dissents in discrimination cases suggests that the tribunals have encountered some difficulty in handling them. The article points to a gradual but still incomplete approximation of the decisions of such tribunals to contemporary developments in discrimination law, and suggests a possible way forward.
Historical Reconstruction of Subpolar North Atlantic Overturning and Its Relationship to Density
Authors: Roussenov Vassil M. , Williams Richard G. , Lozier M. Susan , Holliday N. Penny , Smith Doug M.
Published: May 2022

The connections between the overturning of the subpolar North Atlantic and regional density changes are assessed on interannual and decadal timescales using historical, data‐based reconstructions of the overturning over the last 60 years and forward model integrations with buoyancy and wind forcing. The data‐based reconstructions reveal a dominant eastern basin contribution to the subpolar overturning in density space and changes in the overturning reaching ±2.5 Sv, which are both in accord with the Overturning in the Subpolar North Atlantic Program (OSNAP). The zonally integrated geostrophic velocity across the basin is connected to boundary contrasts in Montgomery potential in density space. The overturning for the eastern side of the basin is strongly correlated with density changes in the Irminger and Labrador Seas, while the overturning for the western side is correlated with boundary density changes in the Labrador Sea. These boundary density signals are a consequence of local atmospheric forcing and transport of upstream density changes. In forward model experiments, a localized density increase over the Irminger Sea increases the overturning over both sides of the basin due to dense waters spreading to the Labrador Sea. Conversely, a localized density increase over the Labrador Sea only increases the overturning for the western basin and instead eventually decreases the overturning for the eastern basin. Labrador Sea density provides a useful overturning metric by its direct control of the overturning over the western side and lower latitudes of the subpolar basin.
Orbital and In‐Situ Investigation of Periodic Bedrock Ridges in Glen Torridon, Gale Crater, Mars
Authors: Stack Kathryn M. , Dietrich William E. , Lamb Michael P. , Sullivan Robert J. , Christian John R. , Newman Claire E. , O’Connell‐Cooper Catherine D. , Sneed Jonathan W. , Day Mackenzie , Baker Mariah , Arvidson Raymond E. , Fedo Christopher M. , Khan Sabrina , Williams Rebecca M. E. , Bennett Kristen A. , Bryk Alexander B. , Cofield Shannon , Edgar Lauren A. , Fox Valerie K. , Fraeman Abigail A. , House Christopher H. , Rubin David M. , Sun Vivian Z. , Van Beek Jason K.
Published: May 2022

Gale crater, the field site for NASA's Mars Science Laboratory Curiosity rover, contains a diverse and extensive record of aeolian deposition and erosion. This study focuses on a series of regularly spaced, curvilinear, and sometimes branching bedrock ridges that occur within the Glen Torridon region on the lower northwest flank of Aeolis Mons, the central mound within Gale crater. During Curiosity's exploration of Glen Torridon between sols ∼2300–3080, the rover drove through this field of ridges, providing the opportunity for in situ observation of these features. This study uses orbiter and rover data to characterize ridge morphology, spatial distribution, compositional and material properties, and association with other aeolian features in the area. Based on these observations, we find that the Glen Torridon ridges are consistent with an origin as wind‐eroded bedrock ridges, carved during the exhumation of Mount Sharp. Erosional features like the Glen Torridon ridges observed elsewhere on Mars, termed periodic bedrock ridges (PBRs), have been interpreted to form transverse to the dominant wind direction. The size and morphology of the Glen Torridon PBRs are consistent with transverse formative winds, but the orientation of nearby aeolian bedforms and bedrock erosional features raise the possibility of PBR formation by a net northeasterly wind regime. Although several formation models for the Glen Torridon PBRs are still under consideration, and questions persist about the nature of PBR‐forming paleowinds, the presence of PBRs at this site provides important constraints on the depositional and erosional history of Gale crater.
An Outlook for the Acquisition of Marine Sedimentary Ancient DNA (sedaDNA) From North Atlantic Ocean Archive Material
Authors: Selway Caitlin A. , Armbrecht Linda , Thornalley David
Published: May 2022

Studies incorporating sedimentary ancient DNA (sedaDNA) analyses to investigate paleo‐environments have increased considerably over the last few years, and the possibility of utilizing archived sediment cores from previous field campaigns could unlock an immense resource of sampling material for such paleo‐investigations. However, sedaDNA research is at a high risk of contamination by modern environmental DNA, as sub‐optimal sediment storage conditions may allow for contaminants (e.g., fungi) to grow and become dominant over preserved sedaDNA in the sample. Here, we test the feasibility of sedaDNA analysis applied to archive sediment material from five sites in the North Atlantic, collected between 1994 and 2013. We analyzed two samples (one younger and one older) per site using a metagenomic shotgun approach and were able to recover eukaryotic sedaDNA from all samples. We characterized the authenticity of each sample through sedaDNA fragment size and damage analyses, which allowed us to disentangle sedaDNA and contaminant DNA. Although we determined that contaminant sequences originated mainly from Ascomycota (fungi), most samples were dominated by Emiliania huxleyi, a haptophyte species that commonly blooms in the study region. We attribute the presence of contaminants to non‐ideal sampling and sample storage conditions of the investigated samples. Therefore, while we demonstrate that sedaDNA analysis of archival North Atlantic seafloor sediment samples are generally achievable, we stress the importance of best‐practice ship‐board sampling techniques and storage conditions to minimize contamination. We highly recommend the application of robust bioinformatic tools that help distinguish ancient genetic signals from modern contaminants, especially when working with archive material.
Interdecadal Variation in Available Potential Energy of Stationary Eddies in the Midlatitude Northern Hemisphere in Response to the North Pacific Gyre Oscillation
Authors: Leung M. Y.‐T. , Wang D. , Zhou W. , Zhang Y. , Wang L.
Published: May 2022

This study investigates the variation in available potential energy of stationary eddies in the mid‐troposphere over the midlatitude Northern Hemisphere (30°–60°N) from 1950 to 2021, based on the ERA5 reanalysis and its preliminary back extension. The variation is attributed mainly to changes in the wavenumber‐1 eddy. It is also noted that potential energy conversion from the zonal mean flow in early winter plays an important role in the 20‐year variation. In addition, statistical analysis and numerical simulation of an ICTP model demonstrate that the potential energy conversion is controlled by the North Pacific Gyre Oscillation, which induces anomalous meridional temperature advection in the mid‐troposphere over Northeast Asia.
New Paleomagnetic Insights Into the Neoproterozoic Connection Between South China and India and Their Position in Rodinia
Authors: Chang Linxi , Zhang Shihong , Li Haiyan , Xian Hanbiao , Wu Huaichun , Yang Tianshui
Published: May 2022

A paleogeographic affinity of the south China craton (SCC) with India in the Neoproterozoic has long been advocated based on lines of geological evidence. However, the lack of coeval paleomagnetic data renders the putative connection ambiguous. Here we report new paleomagnetic results obtained from seven ca. 770 Ma mafic sills in SCC that provide new critical constraints on the issue. The data quality is assured by a positive regional tilt test, a reversal test, and by adequately averaging‐out paleosecular variation. Our data, together with coeval poles from the global paleomagnetic database, support a reconstruction in which the SCC was connected with India at ca. 770 Ma via linkages with smaller continental blocks. The SCC‐India landmass was located at high‐to‐mid latitudes and far from Laurentia and Australia, which were located at low latitudes at ca. 770 Ma.
Variations in Vertical CO/CO2 Profiles in the Martian Mesosphere and Lower Thermosphere Measured by the ExoMars TGO/NOMAD: Implications of Variations in Eddy Diffusion Coefficient
Authors: Yoshida Nao , Nakagawa Hiromu , Aoki Shohei , Erwin Justin , Vandaele Ann Carine , Daerden Frank , Thomas Ian , Trompet Loïc , Koyama Shungo , Terada Naoki , Neary Lori , Murata Isao , Villanueva Geronimo , Liuzzi Giuliano , Lopez‐Valverde Miguel Angel , Brines Adrian , Modak Ashimananda , Kasaba Yasumasa , Ristic Bojan , Bellucci Giancarlo , López‐Moreno José Juan , Patel Manish
Published: May 2022

Using the Nadir and Occultation for MArs Discovery instrument aboard Trace Gas Orbiter, we derived the CO/CO2 profiles between 75 and 105 km altitude with the equivalent width technique. The derived CO/CO2 profiles showed significant seasonal variations in the southern hemisphere with decreases near perihelion and increases near aphelion. The estimation of the CO/CO2 profiles with a one‐dimensional photochemical model shows that an altitude‐dependent eddy diffusion coefficient better reproduces the observed profiles than a vertically uniform one. Our estimation suggests that the eddy diffusion coefficient in Ls = 240–270 is uniformly larger by a factor of ∼2 than that in Ls = 90–120 in the southern hemisphere, while they are comparable in the northern hemisphere. This fact demonstrates that the eddy diffusion coefficient is variable with season and latitude.
Changing causes of death in persons with haematological cancers 1975–2016
Authors: Chen Lezong , Zheng Yongqiang , Yu Kai , Chen Shuzhao , Wang Weida , Gale Robert Peter , Liu Ze-Xian , Liang Yang
Published: May 2022

Causes of death in persons with haematological cancers include the index cancer, a new cancer or a seemingly unrelated cause such as cardio-vascular disease. These causes are complex and sometimes confounded. We analyzed trends in cause of death in 683,333 persons with an index haematological cancer diagnosed in 1975–2016 reported in the Surveillance, Epidemiology and End Results dataset. Non-cancer deaths were described using standardized mortality ratios. The index cancer was the predominant cause of death amongst persons with plasma cell myeloma, acute lymphoblastic leukaemia and acute myeloid leukaemia. Non-cancer death was the major cause of death in persons with chronic lymphocytic leukaemia, Hodgkin lymphoma and chronic myeloid leukaemia, mostly from cardio-vascular diseases. The greatest relative decrease in index-cancer deaths was amongst persons with Hodgkin lymphoma, chronic myeloid leukaemia and chronic lymphocytic leukaemia, where the proportion of non-cancer deaths increased substantially. Changing distribution of causes of death across haematological cancers reflects substantial progress in some cancers and suggests strategies to improve the survival of persons with haematological cancers in the future.
Enhancing sensitivity in atomic force microscopy for planar tip-on-chip probes
Authors: Çiftçi H. Tunç , Verhage Michael , Cromwijk Tamar , Pham Van Laurent , Koopmans Bert , Flipse Kees , Kurnosikov Oleg
Published: May 2022

We present a new approach to tuning-fork-based atomic force microscopy for utilizing advanced “tip-on-chip” probes with high sensitivity and broad compatibility. Usually, such chip-like probes with a size reaching 2 × 2 mm2 drastically perturb the oscillation of the tuning fork, resulting in poor performance in its intrinsic force sensing. Therefore, restoring initial oscillatory characteristics is necessary for regaining high sensitivity. To this end, we developed a new approach consisting of three basic steps: tuning-fork rebalancing, revamping holder-sensor fixation, and electrode reconfiguration. Mass rebalancing allows the tuning fork to recover the frequency and regain high Q-factor values up to 104 in air and up to 4 × 104 in ultra-high vacuum conditions. The floating-like holder-fixation using soft wires significantly reduces energy dissipation from the mounting elements. Combined with the soft wires, reconfigured electrodes provide electrical access to the chip-like probe without intervening in the force-sensing signal. Finally, our easy-to-implement approach allows converting the atomic force microscopy tip from a passive tool to a dedicated microdevice with extended functionality.
IGF-1 release in the medial prefrontal cortex mediates the rapid and sustained antidepressant-like actions of ketamine
Authors: Deyama Satoshi , Kondo Makoto , Shimada Shoichi , Kaneda Katsuyuki
Published: May 2022

Ketamine, an N-methyl-D-aspartate receptor antagonist, exerts rapid and sustained antidepressant actions. Preclinical studies demonstrated that the release of brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor in the medial prefrontal cortex (mPFC) is essential for the antidepressant-like effects of ketamine. However, the role of other neurotrophic factors in the antidepressant-like effects of ketamine has not been fully investigated. Since the intra-mPFC infusion of insulin-like growth factor 1 (IGF-1) reportedly produced antidepressant-like effects, the present study examined the role of endogenous intra-mPFC IGF-1 signaling in the antidepressant-like actions of ketamine. In vivo microdialysis showed that ketamine (10 and 30 mg/kg) significantly increased extracellular IGF-1 levels in the mPFC of male C57BL/6J mice for at least 5 h. Infusion of an IGF-1 neutralizing antibody (nAb; 160 ng/side) into the mPFC 15 min before or 2 h after ketamine injection blocked the antidepressant-like effects of ketamine in three different behavioral paradigms (forced swim, female urine sniffing, and novelty-suppressed feeding tests were conducted 1, 3 and 4 days post-ketamine, respectively). The ketamine-like antidepressant-like actions of the intra-mPFC infusion of BDNF (100 ng/side) and IGF-1 (50 ng/side) respectively were not blocked by co-infused IGF-1 nAb and BDNF nAb (200 ng/side). Moreover, intra-mPFC infusion of IGF-1 nAb 2 h post-ketamine blocked the antidepressant-like effects of ketamine in a murine lipopolysaccharide (LPS)-induced depression model. Intra-mPFC IGF-1 infusion also produced antidepressant-like effects in the LPS-challenged mice via mechanistic target of rapamycin complex 1 activation. These results suggest that persistent release of IGF-1, independently of BDNF, in the mPFC is essential for the antidepressant-like actions of ketamine.
SFMBT1 facilitates colon cancer cell metastasis and drug resistance combined with HMG20A
Authors: Pan Ruijun , Yu Dingye , Hu Jiajia , Yang Xiao , Wang Chenxing , Zhang Luyang , Xue Pei , Sun Jing , Zhang Xiaoping , Cai Wei
Published: May 2022

In colorectal cancer (CRC), the development of reagents that increase sensitivity to chemotherapeutic agents could prevent drug resistance and improve patient survival. Scm-like with four malignant brain tumor domains 1 (SFMBT1) is up-regulated in CRC tumor tissues and cells and may be associated with drug resistance. We detected the expression of SFMBT1 in CRC tissue microarrays by immunohistochemistry. The role of SFMBT1 in the migration, proliferation and invasion of CRC or resistance to 5-fluorouracil (5-FU) was determined using scratch assay, colony formation and Transwell assay. Fluorescence co-localization and immunoprecipitation were used to analyze the correlation between SFMBT1 and high mobility group domain-containing protein 20 A (HMG20A). Xenograft experiments were conducted to investigate the role of SFMBT1 and HMG20A in tumor growth and metastasis in vivo. We found that SFMBT1 is up-regulated in CRC and its expression is further amplified in 5-FU resistance. SFMBT1 drives 5-FU resistance and CRC proliferation, migration and invasion. Correlation analysis shows that SFMBT1 and HMG20A are positively correlated. Mechanistically, fluorescence co-localization and immunoprecipitation assay indicate an interaction between SFMBT1 and HMG20A. Depletion of SFMBT1 down-regulates HMG20A downstream. These results were verified by murine xenograft and lung metastasis models. Our results indicate that the SFMBT1/HMG20A axis could be targeted to increase the resistance of CRC cells to 5-FU.
Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis
Authors: Kiweler Nicole , Delbrouck Catherine , Pozdeev Vitaly I. , Neises Laura , Soriano-Baguet Leticia , Eiden Kim , Xian Feng , Benzarti Mohaned , Haase Lara , Koncina Eric , Schmoetten Maryse , Jaeger Christian , Noman Muhammad Zaeem , Vazquez Alexei , Janji Bassam , Dittmar Gunnar , Brenner Dirk , Letellier Elisabeth , Meiser Johannes
Published: May 2022

Metastasis is the most common cause of death in cancer patients. Canonical drugs target mainly the proliferative capacity of cancer cells, which leaves slow-proliferating, persistent cancer cells unaffected. Metabolic determinants that contribute to growth-independent functions are still poorly understood. Here we show that antifolate treatment results in an uncoupled and autarkic mitochondrial one-carbon (1C) metabolism during cytosolic 1C metabolism impairment. Interestingly, antifolate dependent growth-arrest does not correlate with decreased migration capacity. Therefore, using methotrexate as a tool compound allows us to disentangle proliferation and migration to profile the metabolic phenotype of migrating cells. We observe that increased serine de novo synthesis (SSP) supports mitochondrial serine catabolism and inhibition of SSP using the competitive PHGDH-inhibitor BI-4916 reduces cancer cell migration. Furthermore, we show that sole inhibition of mitochondrial serine catabolism does not affect primary breast tumor growth but strongly inhibits pulmonary metastasis. We conclude that mitochondrial 1C metabolism, despite being dispensable for proliferative capacities, confers an advantage to cancer cells by supporting their motility potential.
Dynamic recognition and mirage using neuro-metamaterials
Authors: Qian Chao , Wang Zhedong , Qian Haoliang , Cai Tong , Zheng Bin , Lin Xiao , Shen Yichen , Kaminer Ido , Li Erping , Chen Hongsheng
Published: May 2022

Breakthroughs in the field of object recognition facilitate ubiquitous applications in the modern world, ranging from security and surveillance equipment to accessibility devices for the visually impaired. Recently-emerged optical computing provides a fundamentally new computing modality to accelerate its solution with photons; however, it still necessitates digital processing for in situ application, inextricably tied to Moore’s law. Here, from an entirely optical perspective, we introduce the concept of neuro-metamaterials that can be applied to realize a dynamic object- recognition system. The neuro-metamaterials are fabricated from inhomogeneous metamaterials or transmission metasurfaces, and optimized using, such as topology optimization and deep learning. We demonstrate the concept in experiments where living rabbits play freely in front of the neuro-metamaterials, which enable to perceive in light speed the rabbits’ representative postures. Furthermore, we show how this capability enables a new physical mechanism for creating dynamic optical mirages, through which a sequence of rabbit movements is converted into a holographic video of a different animal. Our work provides deep insight into how metamaterials could facilitate a myriad of in situ applications, such as illusive cloaking and speed-of-light information display, processing, and encryption, possibly ushering in an “Optical Internet of Things” era.
Earth’s geodynamic evolution constrained by 182W in Archean seawater
Authors: Mundl-Petermeier A. , Viehmann S. , Tusch J. , Bau M. , Kurzweil F. , Münker C.
Published: May 2022

Radiogenic isotope systems are important geochemical tools to unravel geodynamic processes on Earth. Applied to ancient marine chemical sediments such as banded iron formations, the short-lived 182Hf-182W isotope system can serve as key instrument to decipher Earth’s geodynamic evolution. Here we show high-precision 182W isotope data of the 2.7 Ga old banded iron formation from the Temagami Greenstone Belt, NE Canada, that reveal distinct 182W differences in alternating Si-rich (7.9 ppm enrichment) and Fe-rich (5.3 ppm enrichment) bands reflecting variable flux of W from continental and hydrothermal mantle sources into ambient seawater, respectively. Greater 182W excesses in Si-rich layers relative to associated shales (5.9 ppm enrichment), representing regional upper continental crust composition, suggest that the Si-rich bands record the global rather than the local seawater 182W signature. The distinct intra-band differences highlight the potential of 182W isotope signatures in banded iron formations to simultaneously track the evolution of crust and upper mantle through deep time.
Abnormal nonlinear optical responses on the surface of topological materials
Authors: Xu Haowei , Wang Hua , Li Ju
Published: May 2022

The nonlinear optical (NLO) responses of topological materials are under active research. Most previous works studied the surface and bulk NLO responses separately. Here we develop a generic Green’s function framework to investigate the surface and bulk NLO responses together. We reveal that the topological surface can behave disparately from the bulk under light illumination. Remarkably, the photocurrents on the surface can flow in opposite directions to those in the bulk interior, and the light-induced spin current on the surface can be orders of magnitude stronger than its bulk counterpart on a per-volume basis. We also study the responses under inhomogeneous field and higher-order NLO effect, which are all distinct on the surface. These anomalous surface responses suggest that light can be a valuable tool for probing the surface states of topological materials. Besides, the surface effects should be prudently considered when investigating the optical properties of topological materials.
Ultrafast proton-coupled isomerization in the phototransformation of phytochrome
Authors: Yang Yang , Stensitzki Till , Sauthof Luisa , Schmidt Andrea , Piwowarski Patrick , Velazquez Escobar Francisco , Michael Norbert , Nguyen Anh Duc , Szczepek Michal , Brünig Florian Nikolas , Netz Roland Rüdiger , Mroginski Maria Andrea , Adam Suliman , Bartl Franz , Schapiro Igor , Hildebrandt Peter , Scheerer Patrick , Heyne Karsten
Published: May 2022

The biological function of phytochromes is triggered by an ultrafast photoisomerization of the tetrapyrrole chromophore biliverdin between two rings denoted C and D. The mechanism by which this process induces extended structural changes of the protein is unclear. Here we report ultrafast proton-coupled photoisomerization upon excitation of the parent state (Pfr) of bacteriophytochrome Agp2. Transient deprotonation of the chromophore’s pyrrole ring D or ring C into a hydrogen-bonded water cluster, revealed by a broad continuum infrared band, is triggered by electronic excitation, coherent oscillations and the sudden electric-field change in the excited state. Subsequently, a dominant fraction of the excited population relaxes back to the Pfr state, while ~35% follows the forward reaction to the photoproduct. A combination of quantum mechanics/molecular mechanics calculations and ultrafast visible and infrared spectroscopies demonstrates how proton-coupled dynamics in the excited state of Pfr leads to a restructured hydrogen-bond environment of early Lumi-F, which is interpreted as a trigger for downstream protein structural changes.