bluuebunny/crossref_metadata_2025 huggingface dataset:
Key Attributes and Clusters of the Korean Exercise Healthcare Industry Viewed through Big Data: Comparison before and after the COVID-19 Pandemic
Authors: Park Sung-Un , Jang Deok-Jin , Kim Dong-Kyu , Choi Chulhwan
Published: July 2023

This study aims to predict the characteristics of the exercise healthcare industry in the post-pandemic era by comparing the periods before and after the coronavirus disease 2019 outbreak through big data analysis. TEXTOM, the Korean big data collection and analysis solution, was used for data collection. The pre-pandemic period was defined as 1 January 2018–31 December 2019 and the pandemic period as 1 January 2020–31 December 2021. The keywords for data collection were “exercise + healthcare + industry”. Text mining and social network analysis were conducted to determine the overall characteristics of the Korean exercise healthcare industry. We identified 30 terms that appeared most frequently on social media. Four common (smart management, future technology, fitness, and research) and six different clusters (sports education, exercise leader, rehabilitation, services, business, and COVID-19) were obtained for the pre-pandemic and pandemic periods. Smart management, future technology, fitness, and research are still important values across both periods. The results provide meaningful data and offer valuable insights to explore the changing trends in exercise healthcare.
Personalizing Digital Health: Adapting Health Technology Systems to Meet the Needs of Different Older Populations
Authors: Jimenez Jennifer , del Rio Alberto , Berman Arianna N. , Grande Miriam
Published: July 2023

The ageing of the population is growing significantly and will challenge healthcare systems. Chronic diseases in the older population require a change in service delivery, and new technologies can be a key element in ensuring the viability and sustainability of these systems. However, the generation gap and the physical and cognitive decline commonly associated with the older generation are barriers to the transition to these models of care. Despite this, there has been a trend towards digital healthcare, which has many potential benefits for the older population. Numerous studies have assessed the acceptability of new technologies for older people in healthcare. These studies highlight the importance of perceived usefulness, compatibility, ease of use and personalisation of the technology. Personalisation is necessary to ensure that the system is useful for users, and different characteristics such as country of origin, gender, age, or comfort with the technology should be taken into account. A person-centred approach in the development of new health technology systems is essential to ensure that applications can be better tailored to the needs of different ageing populations. Many organisations have dedicated time and resources to ensure a person-centred approach in the development of new health technology systems, and putting the individual first is the best way forward in digital health. This article presents the work carried out in this regard in the framework of the European TeNDER project together with an analysis of the results obtained in terms of satisfaction, usefulness, and usability from end-users. The dynamic and continuous process carried out throughout the TeNDER project translates the needs reported by users, as far as personalisation of interactions is concerned. All end-users held a positive opinion about the usability and usefulness of the system.
Reply to Rossettini et al. “Do Not Mix Apples with Oranges” to Avoid Misinterpretation of Placebo Effects in Manual Therapy: The Risk Is Resulting in a Fruit Basket. Comment on “Molina-Álvarez et al. Manual Therapy Effect in Placebo-Controlled Trials: A Systematic Review and Meta-Analysis. Int. J. Environ. Res. Public Health 2022, 19, 14021”
Authors: Molina-Álvarez Miguel , Arribas-Romano Alberto , Rodríguez-Rivera Carmen , García Miguel M. , Fernández-Carnero Josué , Armijo-Olivo Susan , Goicoechea Garcia Carlos
Published: July 2023

We have thoroughly reviewed and carefully analyzed the points raised in the comment titled: “Do not mix apples with oranges” to avoid misinterpretation of placebo effects in manual therapy: the risk is resulting in a fruit basket [...]
An Exploratory Study Investigating the Prevalence of Gastrointestinal Symptoms in Collegiate Division I American Football Athletes
Authors: Wardenaar Floris C. , Schott Kinta D. , Mohr Alex E. , Ortega-Santos Carmen P. , Connolly John E.
Published: July 2023

Gastrointestinal (GI) symptoms may limit performance, but their prevalence and impact among team sports athletes is not well-documented. The objective of this study was to examine the prevalence of GI symptoms in a small sample of collegiate DI American football athletes, using a survey including the Gastrointestinal Symptoms Ratings Scale (GSRS). Forty-six athletes responded to the survey and reported scores for the 15-question GSRS with additional questions about dietary habits and supplement use. A total of 44 athletes were included in the study (45% of the current roster, age: 20.7 ± 1.7 years, 50% Afro-American or black, 39% skill position, 18% NSAIDs use, and 41% reporting protein supplement use); approximately half of the athletes (52%) reported experiencing GI complaints during exercise. Two-thirds of the athletes (61%) reported at least one or more GI symptoms in general, and 50% reported at least four moderate complaints. Seven athletes (16%) reported ≥2 severe GI symptoms with 5–13 moderate complaints. The most reported symptom was stomach pain (39%, n = 17), followed by hunger pain (36%, n = 16). Athletes reporting the use of protein supplements reported a higher GSRS score (22.0 and interquartile range (IQR) 17.0–31.8) vs. athletes not reporting protein use (15.0 and IQR 15.0–19.3), p = 0.001. Most athletes surveyed reported experiencing GI symptoms. A small group of these athletes reported multiple, varied, and severe symptoms that were associated with self-reported protein supplement use. In conclusion, the number of complaints varied among athletes, confirming the value of integrating the GSRS for screening purposes, and the expected need for individual dietary treatment approaches.
Antioxidants Amelioration Is Insufficient to Prevent Acrylamide and Alpha-Solanine Synergistic Toxicity in BEAS-2B Cells
Authors: Eltayeb Hoda Awad , Stewart Leandra , Morgem Mounira , Johnson Tommie , Nguyen Michael , Earl Kadeshia , Sodipe Ayodotun , Jackson Desirée , Olufemi Shodimu-Emmanuel
Published: July 2023

Cells produce free radicals and antioxidants when exposed to toxic compounds during cellular metabolism. However, free radicals are deleterious to lipids, proteins, and nucleic acids. Antioxidants neutralize and eliminate free radicals from cells, preventing cell damage. Therefore, the study aims to determine whether the antioxidants butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) will ameliorate the maximum dose of acrylamide and alpha (α)-solanine synergistic toxic effects in exposed BEAS-2B cells. These toxic compounds are consumed worldwide by eating potato products. BEAS-2B cells were simultaneously treated with BHA 10 μM and BHT 20 μM and incubated in a 5% CO2 humidified incubator for 24 h, followed by individual or combined treatment with acrylamide (3.5 mM) and α-solanine (44 mM) for 48 h, including the controls. Cell morphology, DNA, RNA, and protein were analyzed. The antioxidants did not prevent acrylamide and α-solanine synergistic effects in exposed BEAS-2B cells. However, cell morphology was altered; polymerase chain reaction (PCR) showed reduced RNA constituents but not DNA. In addition, the toxic compounds synergistically inhibited AKT/PKB expression and its downstream genes. The study showed BHA and BHT are not protective against the synergetic toxic effects of acrylamide and α-solanine in exposed BEAS-2B cells.
Therapeutic Effect of C-Vx Substance in K18-hACE2 Transgenic Mice Infected with SARS-CoV-2
Authors: Ulbegi Polat Hivda , Abaci Irem , Tas Ekiz Arzu , Aksoy Ozge , Oktelik Fatma Betul , Yilmaz Vuslat , Tekin Saban , Okyar Alper , Oncul Oral , Deniz Gunnur
Published: July 2023

C-Vx is a bioprotective product designed to boost the immune system. This study aimed to determine the antiviral activity of the C-Vx substance against SARS-CoV-2 infection. The effect of C-Vx in K18-hACE2 transgenic mice against the SARS-CoV-2 virus was investigated. For this purpose, ten mice were separated into experimental and control groups. Animals were infected with SARS-CoV-2 prior to the administration of the product to determine whether the product has a therapeutic effect similar to that demonstrated in previous human studies, at a histopathological and molecular level. C-Vx-treated mice survived the challenge, whereas the control mice became ill and/or died. The cytokine-chemokine panel with blood samples taken during the critical days of the disease revealed detailed immune responses. Our findings showed that C-Vx presented 90% protection against the SARS-CoV-2 virus-infected mice. The challenge results and cytokine responses of K18-hACE2 transgenic mice matched previous scientific studies, demonstrating the C-Vx’s antiviral efficiency.
Protective Properties of Spheroidal Taxifolin Form in Streptozotocin-Induced Diabetic Rats
Authors: Taldaev Amir , Savina Anastasiya D. , Olicheva Vera V. , Ivanov Sergey V. , Terekhov Roman P. , Ilyasov Igor R. , Zhevlakova Anastasiya K. , Selivanova Irina A.
Published: July 2023

One of the key factors in the pathogenesis of diabetes and its complications is oxidative stress. To inhibit this process, antioxidants may be helpful. Herein, we focused on the protective properties of taxifolin spheroidal form (TS) in the streptozotocin rat model of diabetes mellitus. After 4 weeks of treatment with TS, the fasting blood glucose level of the diabetic animals decreased by 12% compared with the level right after the injection of streptozotocin. While the feed intake in the untreated diabetic rats increased by 5.3% compared with the healthy group, the TS-treated group showed a pronounced 15.3% decrease. Therapeutic administration of TS has a protective effect on the pancreas and the liver against the cytotoxic action of streptozotocin. The plasma antioxidant capacity of all diabetic groups appeared to be approximately 15% lower than in healthy rats with no significant difference between the TS-treated and untreated diabetic animals. Apparently, this can be attributed to taxifolin and plasma proteins binding. These data demonstrate the potential of TS in antidiabetic therapy.
The Importance of Metabolic and Environmental Factors in the Occurrence of Oxidative Stress during Pregnancy
Authors: Jovandaric Miljana Z. , Babic Sandra , Raus Misela , Medjo Biljana
Published: July 2023

Metabolic changes in pregnant women begin in the first weeks after conception under the influence of placental hormones that affect the metabolism of all nutrients. An increased concentration of total lipids accompanies pregnancy and an increased accumulation of triglycerides in low-density lipoproteins (LDL) particles. Lipids in small dense LDL particles are more susceptible to oxidative modification than normal-density LDL particles. Unlike LDL high-density lipoproteins (HDL), lipoprotein particles have an atheroprotective role in lipid metabolism. The very growth of the fetus depends on the nutrition of both parents, so obesity is not only in the mother but also in the father. Nutritional programming of the offspring occurs through changes in lipid metabolism and leads to an increased risk for cardiometabolic diseases. Pregnancy is accompanied by an increased need for oxygen in the mitochondria of the placenta and a tendency to develop oxidative stress. Oxidative stress represents a disturbance in the balance of oxidation–reduction processes in the body that occurs due to the excessive production of free oxygen radicals that cellular homeostatic mechanisms are unable to neutralize. When the balance with the antioxidant system is disturbed, which happens when free oxygen radicals are in high concentrations, serious damage to biological molecules occurs, resulting in a series of pathophysiological and pathological changes, including cell death. Therefore, oxidative stress plays a significant role in the pathogenesis of many complications that can occur during pregnancy. The oxidative status of pregnant women is also influenced by socioeconomic living conditions, lifestyle habits, diet, smoking, and exposure to environmental air pollution. During a healthy pregnancy, the altered lipid profile and oxidative stress create an increased risk for premature birth and pregnancy-related diseases, and a predisposition to adult diseases.
Recapitulating the Drifting and Fusion of Two-Generation Spheroids on Concave Agarose Microwells
Authors: Pan Rong , Yang Xiaoyan , Ning Ke , Xie Yuanyuan , Chen Feng , Yu Ling
Published: July 2023

Cells with various structures and proteins naturally come together to cooperate in vivo. This study used cell spheroids cultured in agarose micro-wells as a 3D model to study the movement of cells or spheroids toward other spheroids. The formation dynamics of tumor spheroids and the interactions of two batches of cells in the agarose micro-wells were studied. The results showed that a concave bottom micro-well (diameter: 2 mm, depth: 2 mm) prepared from 3% agarose could be used to study the interaction of two batches of cells. The initial tumor cell numbers from 5 × 103 cells/well to 6 × 104 cells/well all could form 3D spheroids after 3 days of incubation. Adding the second batch of DU 145 cells to the existing DU 145 spheroid resulted in the formation of satellite cell spheroids around the existing parental tumor spheroid. Complete fusion of two generation cell spheroids was observed when the parental spheroids were formed from 1 × 104 and 2 × 104 cells, and the second batch of cells was 5 × 103 per well. A higher amount of the second batch of cells (1 × 104 cell/well) led to the formation of independent satellite spheroids after 48 h of co-culture, suggesting the behavior of the second batch of cells towards existing parental spheroids depended on various factors, such as the volume of the parental spheroids and the number of the second batch cells. The interactions between the tumor spheroids and Human Umbilical Vein Endothelial Cells (HUVECs) were modeled on concave agarose micro-wells. The HUVECs (3 × 103 cell/well) were observed to gather around the parental tumor spheroids formed from 1 × 104, 2 × 104, and 3 × 104 cells per well rather than aggregate on their own to form HUVEC spheroids. This study highlights the importance of analyzing the biological properties of cells before designing experimental procedures for the sequential fusion of cell spheroids. The study further emphasizes the significant roles that cell density and the volume of the spheroids play in determining the location and movement of cells.
Mechanism of Social Stress-Related Erectile Dysfunction in Mice: Impaired Parasympathetic Neurotransmission and Ketamine
Authors: Wu Shu-Yu , Chao Tze-Chen , Hsu Chun-Kai , Chang His-Hsien , Yang Stephen Shei-Dei
Published: July 2023

This study aimed to investigate the mechanism underlying social stress (SS)-induced erectile dysfunction (ED) and evaluate the effects of a single subanesthetic dose of ketamine on SS-related ED. Male FVB mice were exposed to retired male C57BL/6 mice for 60 min daily over a 4-week period. In the third week, these FVB mice received intraperitoneal injections of either saline (SSS group) or ketamine (SSK group). Erectile function was assessed by measuring the intracavernosal pressure (ICP) during electrical stimulation of the major pelvic ganglia. Corpus cavernosum (CC) strips were utilized for wire myography to assess their reactivity. Both SSS and SSK mice exhibited significantly lower ICP in response to electrical stimulation than control mice. SS mice showed increased contractility of the CC induced by phenylephrine. Acetylcholine-induced relaxation was significantly reduced in SSS and SSK mice. Sodium nitroprusside-induced relaxation was higher in SSS mice compared to control and SSK mice. Nicotine-induced neurogenic and nitric oxide-dependent relaxation was significantly impaired in both SSS and SSK mice. An immunohistochemical analysis revealed co-localization of tyrosine hydroxylase and neuronal nitric oxide synthase-immunoreactive fibers in the CC. These findings highlight the complex nature of SS-related ED and suggest the limited efficacy of ketamine as a therapeutic intervention.
Asiaticoside Mitigates Alzheimer’s Disease Pathology by Attenuating Inflammation and Enhancing Synaptic Function
Authors: Liu Sai , Chen Long , Li Jinran , Sun Yuan , Xu Yue , Li Zhaoxing , Zhu Zheying , Li Xinuo
Published: July 2023

Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder, hallmarked by the accumulation of amyloid-β (Aβ) plaques and neurofibrillary tangles. Due to the uncertainty of the pathogenesis of AD, strategies aimed at suppressing neuroinflammation and fostering synaptic repair are eagerly sought. Asiaticoside (AS), a natural triterpenoid derivative derived from Centella asiatica, is known for its anti-inflammatory, antioxidant, and wound-healing properties; however, its neuroprotective function in AD remains unclear. Our current study reveals that AS, when administered (40 mg/kg) in vivo, can mitigate cognitive dysfunction and attenuate neuroinflammation by inhibiting the activation of microglia and proinflammatory factors in Aβ1-42-induced AD mice. Further mechanistic investigation suggests that AS may ameliorate cognitive impairment by inhibiting the activation of the p38 MAPK pathway and promoting synaptic repair. Our findings propose that AS could be a promising candidate for AD treatment, offering neuroinflammation inhibition and enhancement of synaptic function.
Gingival Tissue MiRNA Expression Profiling and an Analysis of Periodontitis-Specific Circulating MiRNAs
Authors: Buragaite-Staponkiene Benita , Rovas Adomas , Puriene Alina , Snipaitiene Kristina , Punceviciene Egle , Rimkevicius Arunas , Butrimiene Irena , Jarmalaite Sonata
Published: July 2023

This study aimed to identify the microRNAs (miRNAs) associated with periodontitis (PD) in gingival tissues, and to evaluate the levels of these selected miRNAs in the saliva and blood plasma among participants with and without rheumatoid arthritis (RA). A genome-wide miRNA expression analysis in 16 gingival tissue samples revealed 177 deregulated miRNAs. The validation of the miRNA profiling results in 80 gingival tissue samples revealed that the PD-affected tissues had a higher expression of miR-140-3p and -145-5p, while the levels of miR-125a-3p were significantly lower in inflamed tissues. After a thorough validation, four miRNAs, namely miR-140-3p, -145-5p, -146a-5p, and -195-5p, were selected for further analysis in a larger sample of salivary (N = 173) and blood plasma (N = 221) specimens. Increased salivary levels of miR-145-5p were associated with higher mean values of pocket probing depth and bleeding on probing index. The plasma-derived levels of miR-140-3p were higher among the participants with PD. In conclusion, the gingival levels of miR-140-3p, -145-5p, and -125a-3p were independently associated with PD presence and severity. The salivary and blood plasma levels of the target miRNAs were diversely related to PD. Similar miRNA associations with PD were observed among the participants with and without RA.
Emerging Role of Oral Mesenchymal Stem/Stromal Cells and Their Derivates
Authors: Marconi Guya Diletta , Diomede Francesca , Pizzicannella Jacopo , Trubiani Oriana
Published: July 2023

Mesenchymal stem/stromal cells (MSCs) have fewer ethical, moral, and safety problems in comparison with embryonic stem cells [...]
Protective Effects of 3′-Epilutein and 3′-Oxolutein against Glutamate-Induced Neuronal Damage
Authors: Pap Ramóna , Pandur Edina , Jánosa Gergely , Sipos Katalin , Fritz Ferenc Rómeó , Nagy Tamás , Agócs Attila , Deli József
Published: July 2023

Dietary lutein can be naturally metabolized to 3′-epilutein and 3′-oxolutein in the human body. The epimerization of lutein can happen in acidic pH, and through cooking, 3′-epilutein can be the product of the direct oxidation of lutein in the retina, which is also present in human serum. The 3′-oxolutein is the main oxidation product of lutein. Thus, the allylic oxidation of dietary lutein can result in the formation of 3′-oxolutein, which may undergo reduction either to revert to dietary lutein or epimerize to form 3′-epilutein. We focused on the effects of 3′-epilutein and 3′-oxolutein itself and on glutamate-induced neurotoxicity on SH-SY5Y human neuroblastoma cells to identify the possible alterations in oxidative stress, inflammation, antioxidant capacity, and iron metabolism that affect neurological function. ROS measurements were performed in the differently treated cells. The inflammatory state of cells was followed by TNFα, IL-6, and IL-8 cytokine ELISA measurements. The antioxidant status of the cells was determined by the total antioxidant capacity kit assay. The alterations of genes related to ferroptosis and lipid peroxidation were followed by gene expression measurements; then, thiol measurements were performed. Lutein metabolites 3′-epilutein and 3′-oxolutein differently modulated the effect of glutamate on ROS, inflammation, ferroptosis-related iron metabolism, and lipid peroxidation in SH-SY5Y cells. Our results revealed the antioxidant and anti-inflammatory features of 3′-epilutein and 3′-oxolutein as possible protective agents against glutamate-induced oxidative stress in SH-SY5Y cells, with greater efficacy in the case of 3′-epilutein.
Mitochondrial Dysfunction Associated with mtDNA in Metabolic Syndrome and Obesity
Authors: Todosenko Natalia , Khaziakhmatova Olga , Malashchenko Vladimir , Yurova Kristina , Bograya Maria , Beletskaya Maria , Vulf Maria , Gazatova Natalia , Litvinova Larisa
Published: July 2023

Metabolic syndrome (MetS) is a precursor to the major health diseases associated with high mortality in industrialized countries: cardiovascular disease and diabetes. An important component of the pathogenesis of the metabolic syndrome is mitochondrial dysfunction, which is associated with tissue hypoxia, disruption of mitochondrial integrity, increased production of reactive oxygen species, and a decrease in ATP, leading to a chronic inflammatory state that affects tissues and organ systems. The mitochondrial AAA + protease Lon (Lonp1) has a broad spectrum of activities. In addition to its classical function (degradation of misfolded or damaged proteins), enzymatic activity (proteolysis, chaperone activity, mitochondrial DNA (mtDNA)binding) has been demonstrated. At the same time, the spectrum of Lonp1 activity extends to the regulation of cellular processes inside mitochondria, as well as outside mitochondria (nuclear localization). This mitochondrial protease with enzymatic activity may be a promising molecular target for the development of targeted therapy for MetS and its components. The aim of this review is to elucidate the role of mtDNA in the pathogenesis of metabolic syndrome and its components as a key component of mitochondrial dysfunction and to describe the promising and little-studied AAA + LonP1 protease as a potential target in metabolic disorders.
Is Exercise during Pregnancy a Risk for Gestational Age and Preterm Delivery? Systematic Review and Meta-Analysis
Authors: Barakat Rubén , Zhang Dingfeng , Sánchez-Polán Miguel , Silva-José Cristina , Gil-Ares Javier , Franco Evelia
Published: July 2023

Traditionally, one of the primary concerns regarding exercise during pregnancy has been the potential of reducing gestational age and increasing the likelihood of preterm delivery. The aim of this study was to perform a systematic review about the effects of physical activity (PA) during pregnancy on gestational age and preterm delivery. A systematic review and two meta-analyses were performed (Registration No. CRD42022370770). Data sources from online databases were searched up to November 2022. The review exclusively included studies involving pregnant populations and interventions consisting of PA implemented during pregnancy. The primary outcomes analysed were gestational age, measured in weeks, and the occurrence of preterm deliveries. A total of 57 studies were analysed through two independent meta-analyses for the first one, no association was found between moderate exercise during pregnancy and gestational age (Z = 0.45, p = 0.65, ES = 0.08, 95% CI = −0.06−0.04, I2 = 42%, P heterogeneity = 0.001), showing the exercise group had a higher gestational age. In addition, no differences were found between groups in terms of number of preterm deliveries (RR = 0.96, (95% CI = 0.77–1.21, Z = 0.33, p = 0.74; ES = 0.07; I2 = 31%, P heterogeneity = 0.05)). The findings of this study indicate that there is no association between exercise during pregnancy and reduced gestational age or increased risk of preterm delivery in healthy pregnancies.
Identification of Medication Prescription Errors and Factors of Clinical Relevance in 314 Hospitalized Patients for Improved Multidimensional Clinical Decision Support Algorithms
Authors: Russmann Stefan , Martinelli Fabiana , Jakobs Franziska , Pannu Manjinder , Niedrig David F. , Burden Andrea Michelle , Kleber Martina , Béchir Markus
Published: July 2023

Potential medication errors and related adverse drug events (ADE) pose major challenges in clinical medicine. Clinical decision support systems (CDSSs) help identify preventable prescription errors leading to ADEs but are typically characterized by high sensitivity and low specificity, resulting in poor acceptance and alert-overriding. With this cross-sectional study we aimed to analyze CDSS performance, and to identify factors that may increase CDSS specificity. Clinical pharmacology services evaluated current pharmacotherapy of 314 patients during hospitalization across three units of two Swiss tertiary care hospitals. We used two CDSSs (pharmaVISTA and MediQ), primarily for the evaluation of drug-drug interactions (DDI). Additionally, we evaluated potential drug-disease, drug-age, drug-food, and drug-gene interactions. Recommendations for change of therapy were forwarded without delay to treating physicians. Among 314 patients, automated analyses by both CDSSs produced an average of 15.5 alerts per patient. In contrast, additional expert evaluation resulted in only 0.8 recommendations per patient to change pharmacotherapy. For clinical pharmacology experts, co-factors such as comorbidities and laboratory results were decisive for the classification of CDSS alerts as clinically relevant in individual patients in about 70% of all decisions. Such co-factors should therefore be used for the development of multidimensional CDSS alert algorithms with improved specificity. In combination with local expert services, this poses a promising approach to improve drug safety in clinical practice.
Searching for Balance between Hill Country Pastoral Farming and Nature
Authors: Dymond John R. , Daigneault Adam J. , Burge Olivia R. , Tanner Chris C. , Carswell Fiona E. , Greenhalgh Suzie , Ausseil Anne-Gaelle E. , Mason Norman W. H. , Clarkson Beverley R.
Published: July 2023

Much land has been cleared of indigenous forest for pastoral agriculture worldwide. In New Zealand, the clearance of indigenous forest on hill country has resulted in high food production, but waterways have become turbid, with high nutrient and E. coli concentrations. A range of on-farm mitigations are available, but it is unclear how they should be applied catchment-wide. We have developed a catchment-scale model that integrates economics with ecosystem services to find a better balance between agriculture and nature. In the upper Wairua catchment, Northland, if three actions are prioritised—(1) keeping stock out of streams, (2) constructing flood retention bunds in first-order catchments, and (3) planting trees on highly erodible land—then sediment loads, E. coli levels, and flooding are significantly reduced. Implementing these actions would cost approximately 10% of catchment net revenue, so it is feasible with a combination of regulation and subsidy. Many catchments in New Zealand are primarily pastoral agriculture, as in other countries (in North and South America, Australasia, and the United Kingdom), and would benefit from the analysis presented here to guide development along sustainable pathways. While pastoral agriculture typically stresses waterways, with increased sedimentation and freshwater contaminants, much can be done to mitigate these effects with improved farm and riparian management.
Book Review: Prominski et al. River.Space.Design. Planning Strategies, Methods and Projects for Urban Rivers, 3rd and Enlarged ed.; Birkhäuser: Basel, Switzerland, 2023; ISBN: 978-3035625240; eISBN: 978-3035625271
Authors: Dehghanifarsani Laleh , Khalilnezhad Mohammad Reza , Amani-Beni Majid
Published: July 2023

In every landscape design project, designers usually search for similar completed projects as precedents and inspiration [...]
Geographical Detector-Based Research of Spatiotemporal Evolution and Driving Factors of Oasification and Desertification in Manas River Basin, China
Authors: Lee Jinmeng , Yin Xiaojun , Zhu Honghui , Zheng Xin
Published: July 2023

Oasification and desertification are two essential processes of land use and cover (LULC) change in arid regions. Compared to desertification, which is widely regarded as the most severe global ecological issue, the importance of oasification has not received universal recognition. However, neglecting oasification can lead to detrimental outcomes to the effectiveness of ecological governance by affecting the comprehensiveness of environmental policies proposed only based on desertification. Therefore, this study incorporates oasification into the examination of desertification by analyzing land use data for five representative periods spanning from 1980 to 2020, as well as socioeconomic and environmental data from 2000 to 2010. The aim is to evaluate the spatial and temporal dynamics of oasification and desertification in the Manas River Basin and identify the underlying factors driving these processes. The findings indicated that (1) the general trend of oasification and desertification exhibited the expansion of oases and the retreat of deserts. Specifically, the oasification area showed a “decrease-increase-decrease” pattern over time, while the desertification area consistently decreased. (2) In terms of spatial distribution, oasification and desertification displayed a transition from scattered and disordered patterns to an overall more organized pattern, with the hotspot area of desertification shifting from Shawan County to Manas County over time. (3) Population density, average land GDP, soil type and annual precipitation significantly influenced the degree of oasification, with driving force q-values above 0.4, which were the key factors driving oasification. Population density and average land GDP significantly affected the degree of desertification, with driving force q-values above 0.35, which were the key factors driving desertification. The driving force of all factors increased significantly after the interaction, and socioeconomic factors influenced oasification and desertification more than other factors. The study’s findings aim to provide a scientific basis for land resource use, ecological governance and sustainable development in the Manas River basin.
Association between Obstructive Sleep Apnea and Chronic Kidney Disease According to Sex, Long Working Hours: The Korean National Health and Nutrition Examination Survey (2019–2020)
Authors: Jung Sung-Min , Lee Mee-Ri
Published: July 2023

This study aimed to investigate whether obstructive sleep apnea (OSA) is associated with an increased risk of chronic kidney disease (CKD) and to perform subgroup analysis by sex and working hours. This cross-sectional study was conducted on 8157 subjects who participated in the Korea National Health and Nutrition Examination Survey (KNHANES). The adults completed the STOP-BANG score to measure their risk of OSA, and blood and urine samples were collected to ascertain the severity of CKD based on the estimated glomerular filtration rate and urine albumin-to-creatinine ratio. Multivariate logistic regression was used for complex sample analysis. After fully adjusting for the confounding variables, the high-risk OSA group showed a significantly higher risk of developing albuminuria and CKD than the low-risk group, particularly among men. Odds ratio (OR) 1.72, 95% confidence interval (CI) 1.13–2.6 and (OR 1.67, 95% CI 1.14–2.45), respectively. Additionally, men who worked for 40 h/week showed a significant association between OSA, CKD, and albuminuria. This study supports the link between OSA and the risk of kidney disease, especially among men and those who work long hours. Screening and treating OSA may be a crucial strategy for preventing kidney disease, particularly in high-risk populations.
Non-Contact and Self-Calibrated Photopyroelectric Method for Complete Thermal Characterization of Porous Materials
Authors: Swapna Mohanachandran Nair Sindhu , Tripon Carmen , Gutt Robert , Farcas Alexandra , Bojan Marcel , Korte Dorota , Kacso Irina , Franko Mladen , Dadarlat Dorin
Published: July 2023

A general theory of a photopyroelectric (PPE) configuration, based on an opaque sample and transparent pyroelectric sensor, backing and coupling fluids is developed. A combined back-front detection investigation, based on a frequency scan of the phase of the PPE signals, followed by a self-normalization of the phases’ behavior, leads to the possibility of simultaneously measuring both thermal effusivity and diffusivity of a solid sample. A particular case of this configuration, with no coupling fluid at the sample/backing interface and air instead of coupling fluid at the sample/sensor interface (non-contact method) is suitable for simultaneous measurement ofboth thermal diffusivity and effusivity (in fact complete thermal characterization) of porous solids. Compared with the already proposed configurations for investigations of porous materials, this novel configuration makes use of a fitting procedure with only one fitting parameter, in order to guarantee the uniqueness of the solution. The porous solids belong to a class of materials which are by far not easy to be investigated using PPE. To the best of our knowledge, porous materials represent the only type of compounds, belonging to condensed matter, which were not taken into consideration (until recently) as potential samples for PPE calorimetric investigations. Consequently, the method proposed in this paper complete the area of applications of the PPE method. Applications on some porous building materials and cellulose-based samples validate the theory.
Interdisciplinary Research on Medieval Fresco Subjected to Degradation Processes in the Corbii de Piatră Cave Church
Authors: Vâlcea Adriana Elena , Mariș Izabela , Negrea Aurelian Denis , Cimpoeșu Nicanor , Gârbea Gheorghe , Grecu Dorin , Moga Sorin Georgian , Istrate Bogdan , Finta Flavio Nicolae , Rizea Alin Daniel , Anghel Daniel-Constantin , Munteanu Corneliu , Petrescu Mircea Ionuț , Abrudeanu Mărioara
Published: July 2023

This paper presents research on the degradation processes of the fresco painting in the cave church of Corbii de Piatră Hermitage under the influence of meteoric infiltration water and environmental factors. The medieval fresco dates from the end of the 13th century and the beginning of the 14th century, being painted on a sandstone wall. The infiltration of meteoric water through this wall, the temperature variations, the environment and the repeated wetting/drying processes determined the degradation of the fresco, resulting in its detachment from large surfaces. This research established correlations between the processes that take place, the structural transformations, the changes in composition and the adhesion of the fresco to the sandstone wall. The results have been made available to conservation and restoration specialists, in order to choose appropriate materials and technologies. This paper presents findings regarding the pictorial material and introduces new analysis techniques in research on the degradation processes of the fresco painting in the cave church of Corbii de Piatră Hermitage under the influence of meteoric infiltration water and environmental factors.
The Corrosion Behavior of X100 Pipeline Steel in a Sodium Chloride Solution Containing Magnesium and Calcium
Authors: Yang Xiaoning , Hao Tiancong , Sun Qingya , Zhang Zhongwei , Lin Yuan
Published: July 2023

The influences of Mg2+ and Ca2+ on the short-term (1800 s) corrosion behavior of X100 pipeline steel were investigated in a sodium chloride (NaCl) solution saturated with CO2. Either Ca2+ or Mg2+ in the solution inhibited the short-term corrosion of X100 pipeline steel, with the corrosion current density decreasing from 262.4 μA cm−2 to 163.5 μA cm−2 or 80.8 μA cm−2. During longer-term (8−48 h) immersion, the Mg2+ inhibited the formation of the protective scale, whereas the Ca2+ accelerated the formation of the scale. Further, an experimental equation establishing the relationship between the precipitation rate of the corrosion scale and the exposure time was proposed to quantitatively study the effects of Mg2+ and Ca2+ on the precipitation rate of the corrosion scale.
Structural Characteristics and Microstructure Analysis of Soft Soil Stabilised with Fine Ground Tile Waste
Authors: Md Isa Mohd Hafizan , Koting Suhana , Hashim Huzaifa , Aziz Salsabila Ab , Mohammed Syakirah Afiza
Published: July 2023

Using ceramic tile waste as a soil stabiliser in road construction is a potential solution to dispose of the waste material while providing a cost-effective alternative to traditional stabilising agents. The ceramic tile waste, when crushed and mixed with soil, helps to improve the strength and durability of the road base. However, the effectiveness of the ceramic tile waste as a soil stabiliser depends on the type and size of ceramic tiles used and the soil properties being stabilised. This study investigated the effect of ground tile waste on the plasticity, compatibility, and mechanical properties such as the unconfined compressive strength (UCS), indirect tensile test (IDT), flexural test (FS), and microstructural analysis. A range of soil mixtures was prepared by adding the different percentages of fine tile waste (TW): 5% to 40%. Including tile waste in the soil led to a decrease in its water-holding capacity, reducing the optimum moisture content required for optimal compaction. Meanwhile, the maximum dry density increased. The UCS, IDT, and FS improved when the optimum 15% of TW was used in the mixes. However, the strength decreased after 20% of the TW addition. This effect was particularly pronounced in the presence of excessive TW contents in soil samples without a pozzolanic reaction. Reusing tile waste as a soil stabiliser can significantly reduce the costs of purchasing new materials and helps to conserve natural resources and reduce the environmental impact of waste disposal.
Optimal Synthesis of Novel Phosphonic Acid Modified Diatomite Adsorbents for Effective Removal of Uranium(VI) Ions from Aqueous Solutions
Authors: Kobylinska Natalia , Dudarko Oksana , Gładysz-Płaska Agnieszka , Tertykh Valentyn A. , Majdan Marek
Published: July 2023

The authors synthesized a series of functionalized diatomite-based materials and assessed their U(VI) removal performance. Phosphor-derivative-modified diatomite adsorbents were synthesized by the three-route procedures: polymerisation (DIT-Vin-PAin), covalent (DIT-Vin-PAcov), and non-covalent (DIT-PA) immobilization of the functional groups. The effects of the diatomite modification have been studied using powder XRD, solid state NMR, FTIR spectroscopy, electronic microscopy, EDX, acid–base titrations, etc. The maximum adsorption capacities of DIT-Vin-PAcov, DIT-PA, and DIT-Vin-PAin samples were 294.3 mg/g, 253.8 mg/g, and 315.9 mg/g, respectively, at pH0 = 9.0. The adsorption amount of U(VI) ions using the prepared DIT-Vin-PAin was 95.63%, which is higher compared with that of the natural diatomite at the same concentration. The adsorption studies demonstrated that the phosphonic and hydroxyl groups on the surface of the diatomite played pivotal roles in the U(VI) adsorption. The U(VI) ions as a “hard” Lewis acid could easily form bonds with the “hard” donor P-containing ligands, so that the as-prepared DIT-Vin-PAin sample had excellent adsorption properties. The monolayer adsorption of the analyte on the surface of the raw diatomite and DIT-PA was observed. It was found from the thermodynamic parameters that the uptake of the U(VI) ions by the obtained adsorbents was a spontaneous process with an endothermic effect. Findings of the present work highlight the potential for using modified diatomite as effective and reusable adsorbents for the extraction of U(VI) in the waste, river, and tap waters with satisfactory results.
Transfer Learning Based Fault Detection for Suspension System Using Vibrational Analysis and Radar Plots
Authors: Sai Samavedam Aditya , Venkatesh Sridharan Naveen , Dhanasekaran Seshathiri , Balaji Parameshwaran Arun , Sugumaran Vaithiyanathan , Lakshmaiya Natrayan , Paramasivam Prabhu
Published: July 2023

The suspension system is of paramount importance in any automobile. Thanks to the suspension system, every journey benefits from pleasant rides, stable driving and precise handling. However, the suspension system is prone to faults that can significantly impact the driving quality of the vehicle. This makes it essential to find and diagnose any faults in the suspension system and rectify them immediately. Numerous techniques have been used to identify and diagnose suspension faults, each with drawbacks. This paper’s proposed suspension fault detection system aims to detect these faults using deep transfer learning techniques instead of the time-consuming and expensive conventional methods. This paper used pre-trained networks such as Alex Net, ResNet-50, Google Net and VGG16 to identify the faults using radar plots of the vibration signals generated by the suspension system in eight cases. The vibration data were acquired using an accelerometer and data acquisition system placed on a test rig for eight different test conditions (seven faulty, one good). The deep learning model with the highest accuracy in identifying and detecting faults among the four models was chosen and adopted to find defects. The results state that VGG16 produced the highest classification accuracy of 96.70%.
Analysis of Evolving Hazard Overflows and Construction of an Alert System in the Chinese Finance Industry Using Statistical Learning Methods
Authors: Li Jin
Published: July 2023

With the global economic situation still uncertain and various businesses interconnected within the finance system, financial hazards exhibit characteristics such as rapid propagation and wide scope. Therefore, it is of great significance to analyze evolving changes and patterns of hazard overflow in the finance industry and construct a financial hazard alert system. We adopt the time-varying parameter vector auto-regressive model to examine the degree and evolving characteristics of financial hazard alerts from an industry perspective and construct financial hazard measurement indicators. To effectively prevent financial hazards and consider the non-linear causal relationship between financial hazards and macroeconomic variables, we utilize the long/short-term memory network model, which can capture temporal features, to construct a financial hazard alert system. Furthermore, we explore whether the inclusion of an online sentiment indicator can enhance the accuracy of financial hazard alerts, aiming to provide policy recommendations on strengthening financial market stability and establishing a hazard alert mechanism under macro-prudential supervision.
Enhancing Robustness of Viewpoint Changes in 3D Skeleton-Based Human Action Recognition
Authors: Park Jinyoon , Kim Chulwoong , Kim Seung-Chan
Published: July 2023

Previous research on 3D skeleton-based human action recognition has frequently relied on a sequence-wise viewpoint normalization process, which adjusts the view directions of all segmented action sequences. This type of approach typically demonstrates robustness against variations in viewpoint found in short-term videos, a characteristic commonly encountered in public datasets. However, our preliminary investigation of complex action sequences, such as discussions or smoking, reveals its limitations in capturing the intricacies of such actions. To address these view-dependency issues, we propose a straightforward, yet effective, sequence-wise augmentation technique. This strategy enhances the robustness of action recognition models, particularly against changes in viewing direction that mainly occur within the horizontal plane (azimuth) by rotating human key points around either the z-axis or the spine vector, effectively creating variations in viewing directions. We scrutinize the robustness of this approach against real-world viewpoint variations through extensive empirical studies on multiple public datasets, including an additional set of custom action sequences. Despite the simplicity of our approach, our experimental results consistently yield improved action recognition accuracies. Compared to the sequence-wise viewpoint normalization method used with advanced deep learning models like Conv1D, LSTM, and Transformer, our approach showed a relative increase in accuracy of 34.42% for the z-axis and 10.86% for the spine vector.
Optimal Melanoma Treatment Protocols for a Bilinear Control Model
Authors: Khailov Evgenii , Grigorieva Ellina
Published: July 2023

In this research, for a given time interval, which is the general period of melanoma treatment, a bilinear control model is considered, given by a system of differential equations, which describes the interaction between drug-sensitive and drug-resistant cancer cells both during drug therapy and in the absence of it. This model also contains a control function responsible for the transition from the stage of such therapy to the stage of its absence and vice versa. To find the optimal moments of switching between these stages, the problem of minimizing the cancer cells load both during the entire period of melanoma treatment and at its final moment is stated. Such a minimization problem has a nonconvex control set, which can lead to the absence of an optimal solution to the stated minimization problem in the classes of admissible modes traditional for applications. To avoid this problem, the control set is imposed to be convex. As a result, a relaxed minimization problem arises, in which the optimal solution exists. An analytical study of this minimization problem is carried out using the Pontryagin maximum principle. The corresponding optimal solution is found in the form of synthesis and may contain a singular arc. It shows that there are values of the parameters of the bilinear control model, its initial conditions, and the time interval for which the original minimization problem does not have an optimal solution, because it has a sliding mode. Then for such values it is possible to find an approximate optimal solution to the original minimization problem in the class of piecewise constant controls with a predetermined number of switchings. This research presents the results of the analysis of the connection between such an approximate solution of the original minimization problem and the optimal solution of the relaxed minimization problem based on numerical calculations performed in the Maple environment for the specific values of the parameters of the bilinear control model, its initial conditions, and the time interval.