bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk Factor Analysis of Neonatorum Sepsis in NICU Room Naibonat Hospital, Kupang Regency
Authors: Libing Rossita Masi , Manongga Stefanus P. , Lada Christina O
Published: October 2022

Abstract: Neonatal sepsis is one of the causes of newborn death. Risk factors that can affect neonatal sepsis include maternal risk factors, infectious agent factors, infant risk factors and determinant factors. The purpose of this study was to determine and analyze the factors that influence the incidence of neonatal sepsis in the NICU room at the Naibonat Hospital, Kupang Regency. The design of this study used a case control research design (case control) with a retrospective study approach. The populations in this study were all newborns diagnosed with neonatal sepsis at the Naibonat Hospital, Kupang Regency from January to December 2020 totaling 85 cases. The sample size in this study was taken using a total sampling technique, where the entire population was used as a research sample, namely as many as 85 case samples, with a sample size ratio of 1:1 between cases and controls, so the total sample size was 170 samples. The results showed that maternal risk factors that significantly influenced the incidence of neonatal sepsis were premature rupture of membranes (p=0.020), Inpartum Fever (p=0.001), history of urinary tract infection (p=0.003) and length of parturition (p=0.006). For infectious agent factors that influence is bacteria (p = 0.009). For the baby risk factor that has an effect is the APGAR score (p = 0.000). Simultaneously, the most influential determinants on the incidence of neonatal sepsis were APGAR scores, labor duration and labor fever.
Client Satisfaction towards Expanded Program on Immunization Service and Associated Factors in Doyogena Woreda, Southern Ethiopia
Authors: Lafore Terefe , Kibamo Bekafe , Ergicho Kebebush , Ezo Elias
Published: October 2022

Abstract: Background: A client’s satisfaction with expanded program immunization services has good effects on her health and ensures the utilization of services. In developing countries, approximately 8 million children die before they reach their fifth birth day. When compared with a child in Western Europe, an Ethiopian child is 30 times more likely to die by his or her fifth-year birth. Objective: To assess client satisfaction with expanded programs on immunization services and associated factors in Doyogena Woreda, southern Ethiopia, 2021. Methods: A facility-based cross-sectional study design was employed from April 12 to May 31/2021. The total sample size was 402. A simple random sampling technique was used to select health facilities, and a systematic random sampling technique was used to select clients. The data were entered by using Epi data Version 3.1 and analyzed by SPSS version 24 software. Frequency, tables and figures were used. Multi colinearity was checked and the goodness of fit test was done using Hosmer-Lemeshow model goodness fit test. Bivariable analysis was done and variables with p value less than 0.025 were entered to multivariable logistic regression analysis. Statistical significance was declared at p value less than 0.05 with 95% confidence interval. Result: The magnitude of clients’ satisfaction with expanded programs on immunization services was 47.2% [95% CI: 42.0-52.2]. Clients in the age group of 20-24 were 3.2 times more satisfied with expanded programs on immunization services than clients in age groups greater than 35 years [AOR: 3.20, 95%CI: 1.11, 9.27], clients travelling less than thirty minutes to reach the health facility were 9.4 times more satisfied with expanded programs on immunization services than clients who travelled more than thirty minutes [AOR: 9.42, 95%CI: 4.79, 18.53] and clients who were informed on the dose of the vaccination were 2.3 times more satisfied with expanded programs on immunization services than clients who were not informed on the dose of the vaccination [AOR: 2.32, 95%CI: 1.29, 4.17]. Conclusion: Nearly half of the clients were satisﬁed towards an expanded immunization service program. More efforts are needed to improve services with respect to health workers’ relationships, communication, waiting time for immunization and provision of health information to enhance satisfaction among clients towards expanded programs on immunization services.
Prevention's Model of Teenage Pregnancy
Authors: Srimekarat Nantaporn , Khetpanya Tawan
Published: October 2022

Abstract: This research studied was a systematic review research aims to 1) study the situation and problems of teenager’s pregnancy in Kalasin Province 2) analyze the situation of teenager’s pregnancy and 3) synthesize research results from literature to utilizations. Conduct to quantitative and qualitative reviews of literature and research. The result was 1) the situation and problem of teenager’s pregnancy in Kalasin province had the lower teenager’s pregnancy and birth rate. But the incidence of pregnant women death in 2020 found that there were 2 teenager’s mothers and teenagers a mother terminating their pregnancies in 2017-2019 was 18, 7 and 12 cases, respectively. 2) An analysis of the situation of teenager’s pregnancy was found that there was factors involved which is a common problem in teen pregnancy and the impact of teenager’s pregnancy. There are many models or methods of managing teenager’s pregnancy problems. 3) Results of research synthesis to provide adaptation it was preventive patterns of teen pregnancy were reflected. The factors that premature pregnancy are beliefs, values and attitudes that are important to the environment from family, friends, technology and media levels and activities promoting the prevention of teenager’s pregnancy include learning activities teenager’s pregnancy prevention program. Through providing information and prevention model to solve the problem of pre-teenager’s pregnancy with public health agencies as the main. However, the effects of teenager’s pregnancy consist of effects on that individual level. The impact on the family level national impact. Suggestion should be promoted to work both proactive and reactive in both hospitals and departments. They should also be designed to prevent teenager’s pregnancy. In addition, policies should be promoted to prevent teenager’s pregnancy both nationally and internationally. Community and family and there should be a developmental study in order to change attitudes towards teen pregnancy.
Mechanistic Insight Hypolipidemic Potential of Ascorbic Acid: In-Silico Molecular Docking
Authors: Yadav Manish Kumar , Malik Jitender K
Published: October 2022

Abstract: Ascorbic acid, also known as vitamin C, is a crucial part of a balanced diet. The history of vitamin C is intertwined with that of the human ailment scurvy, which was perhaps the first to be identified as a deficiency condition in humans. Its signs include diarrhoea, overall weakness, severe bleeding of the tissues and gums, and tiredness. Ascorbic acid is a water-soluble chemical molecule essential to numerous biological functions. The exact mechanism of action for the lipid lowering action of ascorbic acid was still not revealed. With intent to propose the most probable mechanism of action of ascorbic acid the docking based computational analysis has been performed against the lipid lowering drug targets like ATP citrate lyase enzyme, lanosterol 14α-demethylase enzyme, squalene synthase enzyme, and Niemann Pick C1 like Protein. The docking analysis, chemical interactions, followed by the physicochemical based pharmacokinetic profiling has revealed that the ascorbic acid is executing its lipid lowering action via inhibiting the squalene synthase enzyme.
Study of Antibacterial and Antifungal Activities of Schiff Base Complexes of Co (II) and Cu (II) Derived from Salicyldehyde and Diphenylamine
Authors: B Uba , C Muhammad , A Uba , A Muhammad A.
Published: October 2022

Abstract: This paper reports antibacterial and antifungal activities of Schiff base and that’s of its metal (II) complexes (Co, Cu) derived from salicyldehyde and diphenylamine. The Schiff base and its metal (II) complexes were characterized using different analytical techniques like FTIR, melting point, solubility, and molar conductance, The Schiff base and its respective metals complexes were colored. The result from IR analysis revealed bands at 1614cm-1 indicating the formation of azomethine (C=N) confirming the formation of Schiff base. The band at 664cm-1 indicate the formation of complex which is assign to V(M-N) supporting coordination of Schiff base to respective metals. The solubility test result showed that both the Schiff base and complexes are soluble in most organic solvent and insoluble in water. Both the schiff base and complexes revealed sharp melting point and decomposition temperature. The molar conductance data of the complexes in Dimethylsulphoxide (DMSO) show low value of 9 and 10 Ohm-1cm2 mol-1) indicating the complexes are non-electrolytes. The entire compounds were tested for their antibacterial and antifungal activities. The results indicated that the growth of the tested organism was inhibited by the compounds.
The Clinical Effect of Diode Laser in the Treatment of the periodontal Pockets in Comparison with the use of photodynamic therapy (Comparative study)
Authors: Quriba Mohamed A.A. , Harash Prof Tarek , Helmy Dr Naiven
Published: October 2022

Abstract: Background: Periodontal diseases a group of microbial infections that’s found in gingiva and supporting tissues of the teeth. The effect of microorganisms in the periodontitis could be confirmed. Purpose: The current study was conducted to evaluate the effects of Diode laser versus PDT in periodontitis treatment as non-surgical method of treatment. Materials and methods: Thirty patients’ males and females suffering from gingival pockets with age range from 20 to 65 years old from faculty of oral and dental medicine out clinics and selected randomly and divided in 2 groups each group contains fifteen patients. Group A received scaling and root planning in addition to 980 nm diode laser while Group B group received scaling and root planning in addition to PDT. Results: showed statistically significance improvement in group A (F=114.697, P=0.000) and in group B (F=126.308, P=0.000). Also, there was statistically significant difference between the two groups (F=5.904, P=0.000) with most difference in Pocket depth only (F=21.122, P=0.000) with statistically significant differences in post treatment value (F= 2.333, P=0.000) and follow up at one (F=0.700, P=0.019) and six months (F=1.100, P=0.000). Conclusion: Both PDT and Diode therapy have significant effect in pocket depth, bacterial count and bleeding examination in periodontitis treatment, but PDT have Superior effect when pocket depth is the target.
Ecological Education as a Strategy for Optimizing Education Service Standards
Authors: Vitaloka Wulansari , Dilfa Alrizka Hairi , Setyorini Dwi
Published: October 2022

The key to the progress of a nation is through education. The benchmark for the success of a good education system arrangement is when educational institutions make the National Education Standards an indicator of Quality and Educational Services. Therefore, the purpose of this article is to identify Education Ecology in improving educational service standards and implementation strategies in education through synergy with educational ecology. The research method used is descriptive with a literature review. The data obtained were collected through the literature related to content analysis. The accuracy of the study and preventing misinformation in data analysis is then carried out by triangulation between literature review and member checking. This study obtained information about the ecology of education to achieve the quality of Education Service Standards. Education Service Standards are basic services, which are public services containing a mandate that contains main points as signs or guidelines in the implementation of education. Ecology offers a conception of the MSS-Education implementation strategy through synergy between each component in the education ecosystem. In other words, the environment is an important consideration in optimizing the implementation of education in Indonesia.
The Effect of the Montessori Method Aided by Picture Media on Beginning Reading Ability
Authors: Dayanti Sri , A. Arif Tarman , Haslinda
Published: October 2022

The purpose of this study was to determine the effect of the Montessori method with the aid of picture media on the ability to read early. This study uses quasi-experimental design research in the form of a non-equivalent control group design. The population is all second-grade students of SD Inpres Tmannyeleng, Barombong District, Gowa Regency for the 2021/2022 academic year. The sampling technique used purposive sampling, with a sample of 28 students in the experimental class and 27 students in the control class. The data analysis technique in this study used the paired sample t-test. The results showed that there was a significant effect of the application of the Montessori method with the aid of picture media on the early reading ability.
The Effect of Reading Comprehension and Language Attitudes on the Summary Writing Skills of Class IV Students
Authors: Herlina Herlina , Sulfasyah Sulfasyah , Rukli Rukli
Published: October 2022

The study aims to determine the effect of reading comprehension skills and language attitudes on the summary writing skills of fourth grade students at SD Negerei Panaikang 2 Makassar. The type of research used was descriptive quantitative with ex post facto design. The population in this study were all fourth grade students of SD Negeri Panaikang 2 Makassar as many as 80 students. Sampling was done randomly so that a sample of 30 grade IV students of SD Negeri Panaikang 2 Makassar was obtained. The data were analyzed by using the SPSS application to perform normality test data, multicollinearity test, heteroxidity test, partial t test, and simultaneous F test. The result of the study obtained an average value of reading comprehension ability which was 76.83. Regarding the language attitudes, students got an average value of 78.6933. The students summary writing skills got an average score of 74.19. In the inferential statistical test of the sig. value, the ability of reading comprehension on summary writing skills was 0,001 < 0,05 and language attitudes towards summary writing skills was 0,040 < 0,05, showing that the X1 variable had an effect on the variable and the X2 variable had an effect on Y. The result of the simultaneous F test resulted in a significant value of 0,000 < 0,05 stating that the ability of reading comprehension and language attitudes had a significant effect on the summary writing skills of fourth grade students at State Elementary School Panaikang 2 Makassar.
The Influence of Self-Efficacy and Educational Environment on Interest in Continuing Study in Higher Education (Case Study of Grade 12 Students of SMA Negeri 1 Cerme)
Authors: Thoriq Hafis , Rafsanjani Mohamad Arief
Published: October 2022

This study is a study that aims to determine the effect of the independent variables in the form of self-efficacy, family environment, school environment, and community environment with the dependent variable in the form of interest in continuing study to college in grade 12 students of SMA Negeri 1 Cerme. using a quantitative approach. In this study, the population used were all 12th graders of SMA Negeri 1 Cerme, totaling 430 students, and the sample used in this study was 207 students. The data analysis technique used in this research is using multiple regression analysis. In this study, it was found that (1) the Self-efficacy variable had a significant positive effect on the interest in continuing to study at university in 12th-grade students of SMA Negeri 1 Cerme. (2) The family environment variable has a significant positive effect on the interest in continuing to study at university in grade 12 students of SMA Negeri 1 Cerme. (2) The Self efficacy variable has a significant positive effect on the interest in continuing to study in higher education in grade 12 students of SMA Negeri 1 Cerme. (3) School Environment Variables have a significant positive effect on the interest in continuing their studies to higher education in grade 12 students of SMA Negeri 1 Cerme. (4) The community environment variable has a significant positive effect on the interest in continuing to study in higher education in grade 12 students of SMA Negeri 1 Cerme.
The Influence of Teaching Skills and Interests on Teaching Readiness for Economic Education Study Program Students Class of 2018 UNESA
Authors: Syaharani Novita , Rahmawati Rahmawati , Rafsanjani Mohamad Arief
Published: October 2022

This study was conducted during the covid-19, all student activities were limited online, so students could not freely create learning skills. Especially for students enrolled in the 2018 UNESA Economic Education studies program who teach online, and it is doubtful that their skills and interest in teaching will be in teaching readiness later. This study uses a quantitative method that is explanatory to prove the influence of teaching skills and interest on teaching readiness. The sample of this research is students of the 2018 UNESA Economic Education Study Program. Sources of data were obtained from the distribution of questionnaires as well as primary data. Data analysis used linear regression with the help of SPSS version 26 for Windows.  The results of this study indicate that skills affect teaching readiness, but interest in teaching does not affect teaching readiness. This is because teaching readiness is influenced by interest alone without prior knowledge or skills, meaning that interest is just a desire. this desire is not able to make someone ready to teach. So that this research requires skills and interest in teaching to support the teaching readiness of a student
Analisis Cacat Produksi Keramik Dinding dengan Metode Seven Tools dan Quality Function Deployment guna Peningkatan Kualitas di PT Sinar karya Duta Abadi
Authors: Kurniawan Indra , Muslimin Mohammad , Efendi Imaduddin Bahtiar
Published: October 2022

Penelitian ini dilakukan dengan tujuan untuk mencari tahu kecacatan produk yang terjadi pada produk keramik dinding yang diproduksi oleh PT Sinar Karya Duta Abadi dan Solusi bagaimana cara meningkatkan kualitas produk di PT Sinar Karya Duta Abadi. Hasil penelitian menunjukan bahwa ada beberapa faktor yang mempengaruhi kecacatan produk seperti: 1) faktor kelalaian Sumber Daya Manusia yang kurang ahli, kurang teliti hingga sering terburu-buru.  2) faktor lingkungan yang panas, bising dan berdebu. 3) faktor mesin yang error, maintenance dan kurangnya rutinitas checklist mesin. 4) dan tentunya material bahan seperti kadar air yang tidak seimbang terlalu basah atau terlalu kering dan partikel size material terlalu halus atau kasar. Selain itu hasil penelitian juga memperoleh hasil beberapa cacat yang sering terjadi dalam produksi keramik dinding yaitu Spothole, Pinhole, Chipglaze, Flag dan Restcorner. Setelah dilakukan penyebaran kuesioner terhadap responden dapat dihasilkan bahwa yang paling sering ditemui dipasaran adalah kecacatan yang terdapat pada body glaze yang terkelupas diarea sisi samping keramik yang biasa disebut Chipglaze. Dengan demikian perusahaan akan lebih mudah mengetahui apa saja yang harus ditingkatkan agar defect produk tersebut bisa di minimalisir.
PENILAIAN RESIKO POSTUR KERJA MENGGUNAKAN METODE REBA TERHADAP KELUHAN MUSKULOSKELETAL PADA PEKERJAAN PENGELASAN
Authors: Larasati Novianti , Handoko Lukman , Nadia Rachmat Aulia
Published: October 2022

Perusahaan Manufaktur Transportasi merupakan sebuah perusahaan yang menyediakan barang mentah untuk dikelola menjadi sebuah produk yang diminati oleh konsumen. Perusahaan di bidang Manufaktur Transportasi menghasilkan beberapa produk yaitu Lokomotif, Kereta Penumpang, Transportasi Regional, Kereta Rel Listrik (KRL), Gerbong Barang, dll. . Dalam menghasilkan produk tersebut, perusahaan membagi tiap tahapan produksi menjadi beberapa bagian yaitu Pengerjaan plat, Produksi, Pengecatan, Pemasangan komponen, Permesinan, Interior, Quality Control, Perencanaan dan Pengendalian produksi dimana sebagian besar proses pekerjaannya adalah penyambungan beberapa material plat, besi dan baja yang dilakukan dengan metode pengelasan. Dalam proses pengelasan di Perusahaan Manufaktur Transportasi, pekerja melakukan pengelasan dengan posisi jongkok dan membungkuk. Akibat dari pekerjaan tersebut, para pekerja sering mengalami keluhan musculoskeletal. Berdasarkan studi awal menggunakan kuesioner NBM, pekerja pengelasan memiliki risiko musculoskeletal tertinggi pada tubuh bagian atas dan bawah. Dari permasalahan tersebut, maka dilakukan penilaian postur kerja dan pemberian usulan perbaikan fasilitas kerja ergonomis. REBA merupakan metode yang cocok digunakan untuk menganalisis postur tubuh pekerja secara keseluruhan. Hasil evaluasi metode REBA menunjukkan score 8 dengan kategori risiko tinggi, sehingga perlu dilakukan tindakan. Usulan penambahan fasilitas meja dan kursi las ergonomis merupakan tindakan yang dapat digunakan untuk memperbaiki postur tubuh pekerja. Hasil simulasi perbaikan, score REBA dapat diturunkan menjadi 3 dengan tingkat risiko rendah sehingga tidak perlu dilakukan tindakan lagi.
Morphological changes of the spleen after laser and electric knife resection in the early postoperative period. Experimental resea
Authors:   Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin, Moscow, Russia, Hafez Sara G. ,   Faculty of Veterinary Medicine, Matrouh University, Marsa Matrouh, Egypt, Posyabin Sergey V. ,   Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin”, Moscow, Russia, Borkhunova Elena N. ,   Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin”, Moscow, Russia, Shumakov Nikita I. ,   Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin”, Moscow, Russia
Published: October 2022

The search for methods of reliable hemostasis after surgical interventions on the spleen is an urgent problem of veterinary surgery. Due to the peculiarities of the structure of the vascular bed and organ hemodynamics, prolonged and profuse bleeding, life-threatening, occurs when the spleen is damaged. We conducted an experimental morphological study aimed at evaluating the comparative effectiveness of laser resection and electrocoagulation to ensure hemostasis after partial resection of the spleen. The work was carried out on rabbits (14 animals). It is shown that after laser resection, a thick scab forms on the surface of the wound of the spleen, and thrombosis occurs in the underlying tissues. Hemorrhages are observed in the underlying layers of the organ. All this indicates reliable hemostasis. After resection with an electrocoagulator, the scab is thinner, bullae are located in it. In the tissues under the scab, blood clots and hemorrhages are visible, which spread under the capsule and in some cases to the surface of the wound through the scab layer. This indicates the possibility of resumption of bleeding after coagulation. On the 7th day after surgery, both groups showed signs of encapsulation and organization of the necrosis zone, as well as its channeling by blood vessels with migration of lymphoid tissue cells, which indicates regeneration. The data obtained allow us to conclude that the use of a laser for resection of the spleen is accompanied by more reliable hemostasis compared to electrocoagulation, which further creates conditions for organ repair.
Genetic biodiversity of chicken breeds and the level of fractal bio-consolidation of avian myogenesis gene expression
Authors:   All-Russian Scientific Research Institute of Agricultural Microbiology, Moscow, Russia, Vorobyov Nikolay I. , Nikonov Ilya N. ,   Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin”, Moscow, Russia, Selina Marina V. ,   Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin”, Moscow, Russia
Published: October 2022

The purpose of this work is to show that the genetic diversity of chicken breeds is manifested not only at the external phenotypic level, but also at the genetic level in the form of different levels of bioconsolidation of the expression of myogenesis genes in birds. To demonstrate this effect, a mathematical technique was developed based on constructing a fractal portrait of gene expression and calculating the index of fractal bioconsolidation of gene expression, which reflects the fractal features of the location of genes in a fractal portrait. The technique is illustrated by data on the expression of myogenesis genes of several meat and egg-bearing breeds of chickens. Thus, it was shown that the index of fractal bioconsolidation of myogenesis gene expression correlates (among the chicken breeds considered) with the intensity of chicken weight gain and NO release, which demonstrates the increased efficiency of biochemical and genetic processes in chicken organisms with a high level of fractal bioconsolidation of myogenesis gene expression.
Effectiveness of autologous corneas for keratoplasty in dogs and cats. Results of using Reparin-Helper® in the postoperative period
Authors:   Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin, Moscow, Russian Federation, Saroyan Sergey V. , Komarov Sergey V. ,   Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin, Moscow, Russian Federation
Published: October 2022

This article summarizes clinical results in treatment of deep corneal ulcers and descemetocele, in which keratoplasty with autologous cornea was used. Deep corneal ulcers are followed by an acute inflammatory process and high risk of developing complications leading to vision loss. Conservative treatment of such pathologies is long and not always successful. Keratoplasty for corneal transplantation is considered an effective method. The outcome of an operation depends on the transplanted material and the tactics of postoperative treatment. The present study involved 12 animals and evaluated the effectiveness of using autologous cornea for keratoplasty, which was followed by post-operative treatment using a regenerative drug. The authors describe the clinical picture, the techniques involved in the operation, and the results following the dynamic observation of animals. The results show that the use of autologous cornea for deep corneal ulcers can be an effective treatment method. There was no rejection in any of the 12 examined cases, the morphofunctional characteristics of the cornea were preserved. The post-operative treatment included a regenerative drug. The use of a regenerative drug accelerated the healing process, allowed to preserve the transparency of the cornea and reduce the risks of transplant rejection.
COVID-19 in dogs: classification of course and its radiological characteristics
Authors:   Saint-Petersburg State University of Veterinary Medicine, Saint-Petersburg, Russia, Gradova Yulia V. , Kovalev Sergey P. ,   Saint-Petersburg State University of Veterinary Medicine, Saint-Petersburg, Russia
Published: October 2022

COVID-19 causes changes primarily in the respiratory system. Over time, more and more cases of COVID-19 have been reported in animals. It was relevant to classify the course of COVID-19 in dogs to predict outcome and plan therapy. The course of COVID-19 in dogs was divided by the authors into: mild, moderately severe, severe, extremely severe using complex diagnostics. Radiography made a significant contribution to determining the severity of the course of the pathological process. The more severe the clinical picture, the more intense was bronchial pattern dencity and interstitial changes like pneumonia or edema on X-rays. Acute respiratory distress syndrome was observed in an extremely severe course. Severe course was recorded most often. The changes that occur in the respiratory apparatus due to COVID-19 were completely reversible only in dogs with a mild course, but pathological process chronicity was observed in more severe cases. COVID-19 antibodies were presented more than 30 days in the blood of most animals.
Comparative analysis of full genome sequences of african swine fever virus isolates taken from domestic pigs and wild boar in Zabaykalsky Krai of Russian Federation in 2020
Authors:   Federal Centre for Animal Health («ARRIAH»), Vladimir, Russian Federation, Chernyshev Roman S. , Sprygin Alexander V. ,   Federal Centre for Animal Health («ARRIAH»), Vladimir, Russian Federation, Shotin Andrey R. ,   Federal Centre for Animal Health («ARRIAH»), Vladimir, Russian Federation, Igolkin Alexey S. ,   Federal Centre for Animal Health («ARRIAH»), Vladimir, Russian Federation, Mazloum Ali ,   Federal Centre for Animal Health («ARRIAH»), Vladimir, Russian Federation
Published: October 2022

African swine fever virus (ASFV) is the causative agent of african swine fever (ASF) causing a disease characterized by hemorrhagic fever with the lethality rate up to 100%. The spillover into the Russian Federation, EU and Asia caused a considerable damage to the economy of these countries estimated at billions of dollars. Despite the ongoing pandemic, new outbreaks are reported. In 2020 in Russia ASF was reported in Zabaykalskiy kray in wild boars and domestic pigs. In this paper we report the analysis of the isolate «ASFV/Zabaykali 2020/DP-4905» from domestic pigs in comparison to the one reported in wild boars sequenced previsouly. We found that the genome of ASFV/Zabaykali 2020/ DP-4905 contains 189451 base pairs and encodes 189 open-reading frames (ORF), sharing 99,8% identity to Georgia 2007/1 and 99,8% identity to ASFV/Zabaykali 2020/ WB-5314 from wild boars of Zabaykalsky kray. Both isolates from Zabaykalsky kray had no additional tandem repeat sequence (TRS) in the intergenic region between I73R and I329L and belonged to group I like Georgia 2007/1 and no SNPs were identified in their CVR of B602L gene. We also identified a unique SNP G>C at position 204 of ORF E199L that had never been observed before in isolates from Russia and Eurasian countries. Therefore, this ORF can be considered as a new genome marker for grouping isolates, since several novel SNPs were identified in the studied isolates assigning them to seven groups.
Analysis of the epizootic situation in the highlands of Tajikistan
Authors:   Moscow State Academy of Veterinary Medicine and Biotechnology – MVA by K. I. Skryabin, Moscow, Russian Federation, Navruzshoeva Gulnora Sh. , Atovullozoda Rajabmurod A. ,   Institute of Veterinary Medicine of the Tajik Academy of Agricultural Sciences – IVM TAAS, Dushanbe, Republic of Tajikistan, Zhbanova Svetlana Yu. ,   Institute of Veterinary Medicine of the Tajik Academy of Agricultural Sciences – IVM TAAS, Dushanbe, Republic of Tajikistan, Rasulov Snatllo A. ,   Institute of Veterinary Medicine of the Tajik Academy of Agricultural Sciences – IVM TAAS, Dushanbe, Republic of Tajikistan
Published: October 2022

Sheep and goat pox, brucellosis, chlamydia (Chlamidophyla), Newcastle disease and other infectious diseases, many of which were considered rare and exotic in countries with a continental climate, have reappeared. In recent years, resulting in serious economic losses to farmers, public health and food safety in Tajikistan. The Republic of Tajikistan belongs to the mountainous countries, located in Central Asia, in the southeast. The total area of the territory of the republic is 143,1 thousand km2, of which 93,0% are mountains and gorges. The close interaction in the communities of the Pamir mountain regions between people, animals and the environment affects the development of livestock and poultry farming. The difficult epizootic situation for especially dangerous diseases in the countries of Central Asia requires regular physiological and serological monitoring among animals and birds in the mountainous regions of the Pamirs. The data obtained contribute to the optimization of measures to control the spread of mixed infections and increase the sources of income for the local population, as well as solving the economic problems of the region.
The species structure of helminthocenosis of the stone marten (Martes foina) and forest marten (Martes martes) of the North-Western Caucasus
Authors:   Kuban State Agrarian University named after I. T. Trubilin, Krasnodar, Russian Federation, Kravchenko Viktor M. , Kravchenko Galina A. ,   Kuban State Agrarian University named after I. T. Trubilin, Krasnodar, Russian Federation, Itin Gennady S. ,   Kuban State Agrarian University named after I. T. Trubilin, Krasnodar, Russian Federation
Published: October 2022

The article is devoted to the study of the species structure of the helminthocenoses of the stone and forest martens, conducted from 2006 to 2022. 55 corpses of stone martens from the foothill landscape-geographical zone and 64 corpses of forest martens from the foothill and mountain zones of the North-West Caucasus were examined. The analysis of the results of the study showed that the main factor in the formation of helminthocenoses of martens in the study region is the species structure of trophic and epizootic circuits, such links are given predators, and species which play the role of intermediate, additional and reservoir hosts of parasites. During the study period, an increase in the number of parasite species in the structure of helminthocenoses of martens was noted. We associate this fact with the anthropogenic transformation of natural ecosystems and the violation of historically established biocenotic relationships, the main of which is the «parasitehost » system. The marten species living in the study region form and support 15 natural foci of helminthiasis in the North-West Caucasus, including the focus of trichinosis.
Evaluation of sorption isotherms in snacks with pregelatinized cassava
Authors: Cazzaniga Amanda , Brousse M. Marcela , Linares R. Andrés
Published: October 2022

Sorption characteristics are studied for their influence on the storage stability of dehydrated products and their effect on water vapour diffusion. In the present work, the adsorption curves of snacks with and without substitution of wheat flour by dehydrated cassava puree (PDM) were analysed using saturated salt solutions at 10, 30 and 50 ºC.
Type III curves were obtained for the samples with PDM and type II for the control sample. Mathematical modelling was then performed using 8 different equations, obtaining the best fits for the Peleg (R2adjust =0.999-0.988), Ferro Fontan (R2adjust =0.998-0.970) and GAB (R2adjust =0.999-0.955) models. The values of the model constants in some cases turned out to be formulation and temperature dependent, and in general do not show a definite trend.
This can be seen graphically as crossovers between the curves. This crossover of curves has been attributed to the increased exposure of hydrophilic groups due to increased molecular mobility at high humidity and occurrence of the glass transition in the system and/or endothermic dissolution of sugars.
Displasia fibrosa monostótica craneofacial
Authors: Carías Alejandro , Díaz Vilma
Published: October 2022

La displasia fibrosa es una enfermedad benigna del hueso, de base genética y de progresión lenta, que se caracteriza por el reemplazo progresivo del hueso normal por tejido fibrótico. El proceso puede afectar un solo hueso o múltiples huesos (displasia fibrosa monostótica o poliostótica); esta última puede estar asociada con enfermedades sindrómicas, como el síndrome de McCune-Albright. Objetivo Revisar el diagnóstico y tratamiento de los pacientes con displasia fibrosa craneofacial. Materiales y métodos Se realizó una revisión de artículos científicos, en revistas indexadas en línea como técnica para la recolección de información relevante en bases de datos como Scielo, Google Académico, Scopus, PubMed, y Dynamed, con artículos publicados en inglés y español. El periodo de revisión tuvo como límite el 01 de junio de 2020. Los términos de búsqueda fueron: “displasia fibrosa”, “displasia fibrosa monostótica”, y “displasia fibrosa craneofacial”. Obteniéndose 33 artículos. Conclusión La displasia fibrosa monostótica craneofacial es una enfermedad rara, que afecta principalmente la mandíbula, el hueso maxilar y el cornete inferior. Puede cursar asintomática o presentar deformidades faciales, dolor y trastornos visuales. Su diagnóstico es principalmente por estudios de imágenes y la biopsia. El tratamiento quirúrgico debe de ser bien planeado en cada uno de los pacientes, enfocado a deformidades faciales, evitar los trastornos visuales y es necesario cuando se maligniza la lesión.
Estenosis nasofaríngea: a propósito de la leishmania mucocutánea
Authors: Isaza Marín Adriana , Marulanda Marcela , Pérez Diana , Vanegas Gustavo
Published: October 2022

La leishmaniasis es una enfermedad protozoaria intracelular. Una de sus formas de presentación es la mucocutánea, que es secuela de la leishmania cutánea y solo se presenta en el 1 % al 5 % de quienes la padecen. Afecta la mucosa nasal, faríngeay laríngea, lo que ocasiona disnea y disfagia. Se presenta el caso de una paciente de 76 años con síntomas obstructivos nasales, en quien se evidenciaron múltiples sinequias nasales y faringolaríngeas. Ante la sospecha clínica de la enfermedad, es importante recordar que el diagnóstico se realiza a través de la intradermorreacción de Montenegro o títulos de inmunofluorescencia indirecta superiores a 1:16, y su tratamiento incluye el antimonio pentavalente, uno de los más utilizados; sin embargo, este tiene alto grado de recurrencias y efectos secundarios, por lo que la anfotericina B se convierte en el tratamiento de elección.
Mucormicosis orbitorrinocerebral: el manejo más allá de la cirugía. Informe de caso clínico y revisión de la literatura
Authors: Marulanda Marcela , Hoepfner Nathaly , Bohòrquez Daniela , Garcia Diana Isabel , Patricia Perez Diana
Published: October 2022

Introducción: se presenta el caso clínico de un paciente con mucormicosis orbitorrinocerebraly revisión de la literatura. Caso clínico: se trata de hombre de 45 años queconsultó por síntomas nasosinusales manejado ambulatoriamente con múltiples antibióticossin mejoría, por lo cual se realizó manejo quirúrgico con toma de muestrasque revelaron hifas compatibles con mucormicosis. Cuando acudió a la instituciónpresentaba extensión de la infección a todas las cavidades nasales y parte de la basedel cráneo. En la búsqueda de la inmunosupresión, se encontró una diabetes de novode difícil control. Discusión: la mucormicosis orbitorrinocerebral es una enfermedadaltamente invasiva que requiere un manejo multidisciplinario, cirugías seriadas yextendidas, antimicóticos tópicos y sistémicos. El pronóstico mejora y la evoluciónpuede ser favorable cuando se logra controlar la causa de la inmunosupresión, eneste caso la diabetes. Conclusiones: es requisito fundamental realizar un tratamientomultidisciplinario en el abordaje de estos pacientes, tanto en la especialidad clínicacomo en la quirúrgica, psicosocial, nutricional y de rehabilitación.
Minería de datos para la evaluación del riesgo de malignidad en pacientes con nódulos tiroideos con estudio citológico Bethesda IV
Authors: Baquero G. Rogers Leonardo , Diazgranados G. Esteban , León G. Elizabeth , Zambrano Juan de Francisco , Calixto G. Álvaro Eduardo , Rey Andrés Felipe , Palencia Cesar Alfonso , Castañeda Juan Fernando , León G. Erika
Published: October 2022

Introducción: en el campo de la salud, cada decisión representa datos, y las técnicas de minería de datos han empezado a ser una metodología prometedora para el análisis de esta información, especialmente en el diseño de los modelos predictivos.Métodos: estudio observacional analítico de pacientes mayores de 15 años, con reportede punción de aspiración con aguja fina con estudio Bethesda IV, sometidos a manejo quirúrgico en el Hospital de San José de Bogotá. Los datos recogidos de los pacientes se incluyeron en tres grupos: la información sociodemográfica y clínica, los hallazgos en la citología y los reportes de la ecografía. Se realizó el análisis mediante Naive-Bayes, árbol de decisión y redes neuronales. Se usó la herramientaWeka versión 3.8.2. Resultados: de los 427 pacientes, 195 tuvieron resultados de patología de carcinoma de tiroides (45,6 %). Se evidenciaron mejores resultados usando la validación cruzada (10 fold) comparado con partición (66 %), la técnicade Bayes tuvo mejores resultados de clasificación correcta (91,1 %), comparado con la técnica de árbol (87,8 %) y la red neuronal (88,2 %). Conclusiones: el uso de la técnica de Naive Bayes muestra una importante exactitud para determinar la predicciónde riesgo de malignidad en los pacientes con estudio citológico Bethesda IV, lo cual permitiría orientar de forma adecuada el manejo quirúrgico de los pacientes.
Frequency of Depression and Suicidal Thoughts in Young Adults of Pakistan: A Cross- Sectional Study
Authors: Anwar Parivash , Salman Rabiya , Zahra Mehak , Tufail Rabail , Saad bin Sohail Rana , Arshad Laiba
Published: October 2022

Objective: To find the frequency and association of depression and suicidal ideation in young adults.Study design: A descriptive cross-sectional study.Place and Duration of Study: The study was conducted in different areas of Pakistan, including Lahore andKarachi with the main population participating from the Islamabad and Rawalpindi region from May 2016 toAugust 2016.Materials and Methods: Printed and online versions of the questionnaire were filled by conveniently availableyoung adults in different cities of Pakistan between the ages of 15-25 years. Questionnaires were designed inthree parts: Part 1 comprised demographics. Part 2 was the Goldberg Depression Questionnaire which is usedfor depression screening, while Part 3 was the SBQ-R® used to identify individuals having suicide ideation andthose at risk of carrying out a suicide attempt.Results: A high proportion of individuals were in the range of mild-moderate depression, 87 (43.7%), while ahigh proportion of individuals, 139 (69.8%), possessed a suicide score range of 3-6, which corresponds to a verylow suicide attempt risk. The highest suicide score was between 16-18 and was possessed by only 2 (1%)individuals, while the highest depression score, which was any value above 54, was possessed by 45 (22.6%)individuals. Also, with increasing suicide score, the frequency seemed to decrease; 32 (16.1%) for a score rangeof 7-9, 15 (7.5%) for 10-12 score range and 11 (5.5%) for a score range of 13-15. However, the correlationcoefficient between the two had a value of +0.5, so there was a marked positive correlation.Conclusion: The frequency of depression in young adults was considerably high since many of the participantswere exposed to mild, moderate as well as severe depression. Also, there was a positive correlation betweendepression and suicide scores which predicted that depression can be a cause of suicide ideation and attempts.As the depression levels increased, the frequency of suicide tendencies was also salient.

How to cite this: Anwar P, Salman R, Zahra M, Tufail R, Sohail RS, Arshad L. Frequency of Depression and Suicidal Thoughts in Young Adults of Pakistan: A Cross-Sectional Study. Life and Science. 2022; 3(4): 168-173. doi: http://doi.org/10.37185/LnS.1.1.233
Comorbidities and its Effects on COVID-19 Patients Attribute Mortalities at CMH Attock
Authors: Saeed Imran , Ali Amjad , Saeed Awan Afzal , . Manzoor , Iffet Shazia
Published: October 2022

Objective: The aim of this Study was to assess the comorbidities in the severe acute respiratory syndromecoronavirus (COVID-19) infected patients and the risk of underlying diseases in more severe patients comparedto moderate or mild symptomatic patients.Study Design: Retrospective study.Place and Duration of Study: The study was conducted at isolated treatment facility ward of COVID-19 ofCombined Military Hospital CMH, Attock, Pakistan from March 2020 to October 2021.Materials and Methods: The study comprised of a total of 389 confirmed COVID-19 positive cases out of 1990reported cases which included 28 deaths due to comorbid illnesses. Patients were divided in two groups,onegroup having co-morbidities and other group with no comorbidity.Results: There were 389 COVID-19 infected confirmed cases,including 28 deaths of severely ill patients. Thedeaths were mainly associated with comorbidities and were reported in CMH Attockfrom March 2020 to October 2021.Symptoms included fever followed by cough, fatigue, and dyspnea. The most common comorbidities were hypertension and diabetes, followed by cardiovascular disease and diseases of the respiratory system.Conclusion: We assessed the prevalence of comorbidities in the COVID-19 patients and concluded thatunderlying diseases, including hypertension, diseases of respiratory system and cardiovascular diseases, may be risk factors for death inmore severe patients on contrary to moderately or mildly symptomatic patients.

How to cite this: Saeed I, Ali A, Awan AS, Manzoor, Iffet S. Comorbidities and Its Effects in COVID-19 Patients Attribute Mortalities at CMH Attock. 2022; 3(4): 188-191. doi: http://doi.org/10.37185/LnS.1.1.247
Anti-Metastatic Potential of Pakistani Spice Box
Authors: Wajahat Jariya , Naeem Sadaf
Published: October 2022

Inhibition of vascular endothelial growth factor 2 (VEGFR2), cyclooxygenase-2 (COX-2), NFkB inhibiting kinase1 (NIK) and hypoxia inducible factor-2 α(HIF-2 α) nexus can block cancer spread. This study aimed at findingphytochemicals in spices for inhibition of above mentioned target proteins in order to prevent/ treat cancer.The crystal structures for VEGFR2, COX-2, NIK and HIF-2α were downloaded from RCSB protein data bank withPDB IDs of 3VHE, 5IKQ, 4IDT& 4XT2 respectively. (The chemical constituents of the spices: nutmeg, cinnamon,black pepper, red chili, clove, black caraway seed, fennel, star anise, turmeric and coriander were collectedfrom Dr. Duke's phytochemical and ethnobotanical databases. Next the 3D structures of the chemicals weredownloaded from PubChem. These chemicals were then docked against crystal structures of the target proteins using Glide docking software from Schrodinger. The chemicals that docked successfully against 3VHE ( vascular endothelial growth factor receptor 2) included : Apiin, kaempferol, quercetin, cymaroside and capsorubin from red chili with dock scores of (-11.301,-11.076,-10.990,-10.196,-9.82)kcal/mol respectively, quercetin and trichostachine from black pepper with dock scores -11.546 kcal/mol and -9.017 kcal/mol, curcumin from turmeric with -9.019kcal/mol score, quercetin, isokaemferide, rhamnetin and apigetrin from coriander with dock scores of -11.574kcal/mol, -10.894cal/mol, -10.484, -10.364 cal/mol; foeniculoside ii from fennel with dock score -9.065 kcal/mol, procyanidin B-2 from cinnamon with dock score of -9.218 kcal/mol and kaempferide, rhamnocitrin, myricetin, rhamnetin from clove with dock scores of -10.927cal/mol, -10.593cal/mol, -10.467cal/mol, - 9.931cal/mol - 10.59cal/mol respectively. For cyclooxygenase-2 (5IKQ), Rhamnetin 3, 3', 4'-triglucoside from black pepper and procyanidin from cinnamon showed successful docking. For NFkB-inducing kinase (4IDT), cubebin from black pepper and riboflavin from coriander showed successful docking. Successfully docked compounds against 4XT2(hypoxia inducible factor-2) included AC1NQWCK [tert-butyl N-[(2S)-1-[(2S,4R)-2-[[1-(cyclopropylsulfonylcarbamoyl) cyclobutyl]carbamoyl]-4-(7-methoxy-2-phenylquinolin-4 yl)oxypyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamate ] from red chili and catechin from cinnamon. Because of successful in-silico docking with the target proteins, these spices can be predicted as cancer curbing agents. In future these compounds can be tested in vitro and in vivo for their potential inhibitory activity.

How to cite this: Kalsoom J, Naeem S. Anti-Metastatic Potential of Pakistani Spice Box. Life and Science. 2022; 3(4): 206-206. doi: http://doi.org/10.37185/LnS.1.1.258