bluuebunny/crossref_metadata_2025 huggingface dataset:
Virtual Evaluation of a Hospital Congestion Prevention Method
Authors: Hou Wanxin , Qin Shaowen , Thompson Campbell Henry
Published: September 2021

Background: Hospital congestion is a common problem for the healthcare sector. Numerous studies explored reasons for crowding within some parts of the hospital. However, to deal with more general, hospital-wide problems, examining the hospital as a connected whole is necessary. The purpose of this study was to evaluate de-congestion interventions through a whole hospital simulation model and offer objective reasoning to support hospital management decisions.Method: This study tested a congestion prevention method that estimates the current day’s hospital congestion risk level R at a set time every morning, and activates minimum intervention when R is above certain threshold R(C), using a virtual hospital created by simulation modelling. The color-coding system was adopted to demonstrate the impact and the extent of effectiveness of this method in preventing hospital congestions.Results: The results indicated that adding 8 flex beds to the medical department resulted in more reductions (70.93%) of red-days comparing with the surgical ward (37.15%). Red days reduction per affected patient when discharging two medical patients was 0.1 which was higher than when discharging two surgical (0.04) or two long-stay patients (0.07). Also, the efficiency of red days reduction per affected patient is always greater if removing 2 patients than if discharging more patients. Conclusions: The expected outcome based on theoretical prediction of this method was confirmed, that is, applying a less disruptive intervention is often enough, and more cost effective, to reduce the risk level of hospital congestion. Making a small number of extra beds available was a superior solution compared to discharging approaches to reduce crowding in hospitals. In addition, the virtual implementation approach enabled testing of the method at a more detailed level, thereby revealed some interesting findings difficult to achieve theoretically, such as discharging extra two medical inpatients, rather than surgical inpatients, a day earlier on days when R>R(C), would bring more benefits in terms of congestion reduction for the hospital.
Dynamics of Immune Responses are Inconsistent when Trauma Patients are Grouped by Injury Severity Score and Clinical Outcomes
Authors: Yang Ya-Wen , Wu Che-Hsiung , Tsai Huei-Ting , Chen Ying-Ru , Chang Yu-Ping , Han Yin- Yi , Wu Tiffany E. , Hu Ray-Heng
Published: September 2021

Background: The injury severity score (ISS) is used in daily practice to evaluate the severity of trauma patients, however the score is not always consistent with the prognosis. After injury, systemic inflammatory response syndrome (SIRS) and compensatory anti-inflammatory response syndrome (CARS) are related to the prognosis of trauma patients. Methods: Patients who admitted to the Trauma Intensive Care Unit (ICU) were eligible. Whole blood samples were collected at admission, and then 6, 12, 24, 48 and 72 hours after admission. Natural killer (NK) cells, lymphocyte subset population and cytokines release were identified using flow cytometry. We grouped patients by their ISS (≤ 25 and > 25 as very severe injury) and ICU stay (≤ 10 days as a short ICU stay and >10 days as a long ICU stay) for evaluation. Results: Fifty-three patients were enrolled. ICU stay but not ISS was close correlated with activity daily living (ADL) at discharge. Patients with a long ICU stay had an immediate increase in NK cells followed by lymphopenia which persisted for 48 hours. Immediate activation of CD8 + T cells and then exhaustion with a higher programmed cell death-1 (PD-1) expression and suppression of CD4 + T cells with a shift to an anti-inflammatory Th2 phenotype were also observed in the patients with a long ICU stay. When the patients were grouped by ISS, the dynamics of immune responses were inconsistent to those when the patients were grouped by ICU stay. Conclusions: Immune responses are associated with the prognosis of trauma patients, however the currently used clinical parameters may not accurately reflect immune responses. Further investigations are needed to identify accurate predictors of prognosis in trauma patients.
Assessment of Non-linear Imputation of PaO2/FiO2 from SpO2/FiO2 Among Patients Receiving Mechanical Ventilation in China
Authors: Wang Shan , Yusvirazi Liga , Yin Haiyan , Kang Hongjun , Zhao Yan , Wang Li , Brown Samuel M. , Hou Peter C.
Published: September 2021

Objectives: Arterial blood gas measurements are not always immediately available despite their potential relevance to management of mechanically ventilated patients. Retrospective and prospective studies have validated the non-linear imputation of PaO2/FIO2 from SpO2/FIO2, predominantly in USA. In this study, the objective was to validate the non-linear imputation algorithm among mechanically ventilated patients in the Chinese population. Method: Mechanically ventilated patients admitted to the emergency departments or ICUs at two participating hospitals in China were enrolled prospectively. At the time of a clinical arterial blood gas being drawn, SpO2, oximeter waveform characteristics, receipt of vasopressor, and skin pigmentation were simultaneously recorded. For the various imputation methods, we calculated both imputation error and the area under the curve for patients meeting criteria for acute respiratory distress syndrome (PaO2/FIO2 ≤ 300) and moderate-severe acute respiratory distress syndrome (PaO2/FIO2 ≤ 150). Result: We studied 663 arterial blood gases from 646 patients; 177 (26%) arterial blood gases were associated with SpO2 less than or equal to 96%. Non-linear imputation had lower mean absolute error than linear imputation method when SpO2 was less than or equal to 96% (p<0.001). At the PaO2/FiO2 threshold of 300 or less, non-linear imputation AUC (0.90 95% CI 0.85-0/95) was not significantly higher than the AUCs of linear and log-linear imputation methods (0.88 95% CI 0.82-0.94). The same result was shown at the PaO2 /FiO2 threshold of 150 or less. For patients with a threshold SpO2 of 96% or less, AUC analysis yielded similar results between non-linear vs. linear and log-linear imputations. Conclusions: In this cohort of mechanically ventilated patients, non-linear imputation was not superior to linear and log-linear imputations for patients with SpO2 of 96% or less. All strategies performed similarly in estimating PaO2/FIO2 from SpO2/FIO2.
How does Governance Impact Malnutrition ? A Close Look at Factors Associated with Underweight in Children Under 5 Years in Ghana
Authors: Woode George Graves , Birner Regina
Published: September 2021

Undernutrition remains a barrier to achieving the sustainable development goals in most developing countries. The United Nations identified that, the right mix of policies and actions that addresses the numerous, interrelated causes of hunger and undernutrition will be able to achieve Zero Hunger thereby ending hunger and undernutrition . In Ghana, 11% of all children under the age of 5years are underweight. Nutrition programs are traditionally funded through the government of Ghana budgetary allocations, to pay salaries and for the supply of logistics, and training. The objective of the study was to evaluate the effect of human resource capacity and budgetary expenditure on nutrition program outcomes for children under five years using in-depth interviews, anthropometric data on age and weight and data on nutrition human resource and expenditure in three regions from 2014 to 2017 in Ghana. The paper finds using linear mixed effects modeling that human and financial resources are not significant predictors of underweight besides, there are externalities in the implementation of nutrition programs for children under 5years due to poor targeting and information asymmetries, resulting in excludability in consumption of nutrition services, therefore nutrition programs may not be well-coordinated, and implemented pointing to government failure. Mother support groups contributed in reducing undernutrition in children under 5years through the cultivation and consumption of nutrition-sensitive agriculture value chain products .
Development of a Multi-professional and multi-agency Model, PLUSS (mental health, learning, development, collaboration around pre-school children), to Facilitate Early Detection and Support of Pre-School Children with Neurodevelopmental Difficulties in the Swedish Child Health Care – A Description of the Model and Initial Results
Authors: Gustafsson Berit M. , Steinwall Samina , Korhonen Laura
Published: September 2021

Background: Neurodevelopmental difficulties are frequent in preschoolers and constitute a risk for later negative consequences. This article describes the development of a multi-professional and multi-agency model, PLUSS, to facilitate care and interventions for preschoolers with neurodevelopmental difficulties. Methods: The PLUSS-model was developed for children aged 1.5-5 years with a need for a further assessment of neurodevelopmental symptoms. The model is evaluated using a quasi-experimental study design along with qualitative interviews. Outcomes of interest are a) implementation, b) effectiveness related to processes and multi-agency collaboration, c) capacity building among professionals, d) child-related outcomes with a longitudinal follow-up as well as d) parental wellbeing and satisfaction. Results: The model was launched in 2019 and so far, approximately 130 children have been assessed. Results from a pilot study with 62 children (27-72 months; boys: girls 2.65:1) show, using the strengths and difficulties questionnaire (SDQ), that the included children have clinically significant problems. The total mean SDQ score in parental rating was 15 +/- 6 and in preschool teacher ratings 14 +/- 7, exceeding the Swedish cut-off of 12. 54 parents have participated in parental training and rate high levels of satisfaction (mean score 4.5, max 5.0). In addition, 74 pre-school professionals have been trained in early signs of neurodevelopmental difficulties to facilitate early detection. Feedback from these educational activities is encouraging (mean score 4.2, max 5.0). Conclusions: The PLUSS-model enables early detection and interventions for preschool children and their families, without a set diagnosis. The pilot study shows that the screening procedure can detect children with clinically significant problems. In addition, encouraging results have been obtained from both parent- and preschool teacher training. The longitudinal study approach enables both child follow-up and evaluation of interventions provided by the working model. Trial registration: Clinical Trials 2021, PLUSS identifier, NCT04815889. First registration 25/03/2021.
Apigenin Acts as Anti-inflammatory Compound through Reducing IL-1β, IL-6 and TNF-α in LPS-induced Inflammation; in-vivo Study
Authors: Jamshidi Sanaz , Sofiabadi Mohammad , Eslami Mina , Foroughi Farshad
Published: September 2021

Background: Consumption of herbal flavonoids instead of chemical drugs has increased in recent years due to fewer side effects and affordability. In this study, the effect of apigenin was investigated on inflammation induced by lipopolysaccharide in male rat's serum by measuring the pro-inflammatory cytokines, i.e., IL-1β, IL-6, and TNF-α.Methods: 90 male Wistar rats weighing 200 ±2 grams were used and divided into control, sham (solvent), and positive control (dexamethasone 15 mg/kg. ip), and 3 experimental groups which received 5, 15 or 30 mg/kg of apigenin, intraperitoneally. In 30 minutes after interventions, lipopolysaccharide (LPS) [30 μg/kg. ip] was injected. Then, at 4, 12- and 24-hour intervals, rats were anesthetized, and blood samples were prepared intracardially. Samples were centrifuged, and serums were separated and stored at -80 ° C. Measurement of IL-1β, IL-6, and TNF-α were conducted by the enzyme-linked immunosorbent assay (ELISA) method. Data were analyzed using the SPSS software version 19.Results: Pre-injection of apigenin at 5 mg/kg dosage were reduced TNF-α and IL-1β levels at 24-hours after LPS injection, compared to control (for both P <0.05). Pre-injection of 15 mg/kg of apigenin was reduced IL-6 level at 24-hours after LPS injection (P <0.05). Pre-injection of 30 mg/kg of apigenin were reduced TNF-α level at 4- (P <0.05), 12- (P <0.01) and 24- (P <0.01) hours, IL-1β level at 24-hours (P <0.01), and IL-6 level at 4- (P <0.05) and 24- (P <0.01) hours after LPS injection.Conclusions: Apigenin reduces proinflammatory cytokines in serum in acute inflammation induction. This impact is close to the dexamethasone effect as an anti-inflammatory steroid drug.
Adding Value of Chest CT Images to a Personalized Prognostic Model in Acute Respiratory Distress Syndrome: A Retrospective Study
Authors: Wang Yuan-Cheng , Huang Shan , Yu Qian , Meng Xiangpan , Xie Jianfeng , Yang Yi , Ju Shenghong
Published: September 2021

Background: Acute respiratory distress syndrome (ARDS) is a critical disease in the intensive care unit (ICU) with high morbidity and mortality. The accuracy for predicting outcomes of ARDS patients with mechanical ventilation is limited, and most predicting model are based on clinical information. This study aimed to explore the prognostic value of chest CT images in ARDS patients with mechanical ventilation and develop an outperformed predictive model.Methods: The patients diagnosed with ARDS between January 2014 and June 2019 were retrospectively recruited. Clinical information, ventilation parameters, primary causes, illness severity, and chest CT images were collected. Radiomics features were extracted from the levels of the upper, middle, and lower lungs, and were further screened according to the primary outcome (28-day mortality after ARDS onset). Radiomics Scores for each level were computed. The univariate and multivariate logistic regression analyses were applied to figure out risk factors. Various predictive models were constructed and compared.Results: Of 366 ARDS patients recruited in this study, 276 (median age, 64 years [interquartile range, 54–75 years]; 208 male) survive on the Day 28. Among all factors, the APACHE Ⅱ Score (OR, 2.607, 95% CI: 1.896-3.584, P < 0.001), the Radiomics_Score of the middle lung (OR, 2.230, 95% CI: 1.387-3.583, P = 0.01), the Radiomics_Score of the lower lung (OR, 1.633, 95% CI: 1.143-2.333, P = 0.01) was associated with the 28-day mortality. The clinical_radiomics predictive model (AUC, 0.813, 95% CI: 0.767-0.850) show the best performance compared with the clinical model (AUC, 0.758, 95% CI: 0.710-0.802), the radiomics model (AUC, 0.692, 95% CI: 0.641-0.739) and the various ventilator parameter-based models (highest AUC, 0.773, 95% CI: 0.726-0.815).Conclusions: The radiomics features of chest CT images have incremental values in predicting the 28-day mortality in ARDS patients with mechanical ventilation. These results help to build a personalized prognostic prediction model and to stratify high-risk patients.
Evaluate the drying of food waste using cabinet dryer
Authors: khaloahmadi Ahmad , Borghei Ali Mohammad , roustpoor Omid Reza
Published: September 2021

Purpose

In order to reduce leachate from food waste; a food waste dryer with a conventional tray was built, and drying of food waste was investigated.
Methods

Power of 2.7 kW was used as the heat source, and a centrifugal fan with an air volume of 1300 m3/h, 2800 rpm, and 110 pa was used. The experiments were performed at three temperatures of 50, 60, and 70°C and three air velocities of 1, 1.5, and 2 m/s with a thickness of 3 cm. A conventional tray was used for drying. The Drying kinetics, effective moisture diffusivity, activation energy, and dryer energy consumption during drying of food waste were obtained.
Result

The minimum drying process was occurred in temperature of 70°C and air velocity of 2 m/s at the 120 min, and the maximum drying process was happened in temperature of 50°C and air velocity of 1 m/s at the 890 min. The energy consumption of drying process had the lowest value at 70°C of temperature and 2 m/s of inlet air velocity. The highest energy consumption value was related to temperature of 50°C and velocity of 1m/s. Effective moisture diffusivity of waste food during the drying process was in the range of 2.74×10− 9-3.65×10− 8 m2/s. The values of energy of activation were determined between 21.596 and 64 KJ/mol.
Conclusion

Cabinet dryer with a conventional tray can be used for drying food waste in the shortest time with low energy consumption.
Diagnostic Capability of Pupillary Dilation Reflex to Measure Pain In The Critical Analgosedated Patient
Authors: de Abera Yolanda Lopez de Audicana Jimenez , Cueva Ana Vallejo De la , Cortajarena Nerea Aretxabala , Rodero Amaia Quintano , Nuñez Cesar Rodriguez , Gaspar Pedro María Pelegrin , Garcia Zuriñe Itsaso Gil , Fernandez Alejandra Azahara Margüello , Cilla Laura Aparicio , Diez Naiara Parraza
Published: September 2021

Background: Pain continues to be an underdiagnosed problem. Objective tools are needed for its assessment. The objective of this study was to determine the diagnostic performance, validity and reliability of the pupillary dilation reflex (PDR) against the Behavioural Pain Scale (BPS) to assess pain in patients under light-moderate sedation.Methods: A study of diagnostic tests using PDR versus BPS as a reference test was performed. The patients were recruited from the Intensive Care Units of the Araba University Hospital and were consecutively admitted. They were older than 18 years, under intravenous analgosedation, mechanically ventilated and had a BPS score of three and a Richmond Agitation and Sedation Scale (RASS) score between -1 and -4. The responses to a non-painful (NP) stimulus, 10 mA, 20 mA, 30 mA and 40 mA stimuli, and was assessed with the BPS and PDR. PDR measurements were performed with an Algican® pupilometer. Pain was considered to be present at BPS≥4. The receiver operating curve (ROC) was plotted, and the area under the curve (AUC) was calculated. We identified the cut-off points showing the highest sensitivity and specificity. Diagnostic performance was studied based on the Youden index, negative predictive value (NPV), positive predictive value (PPV), accuracy, positive likelihood ratio (PLR), and negative likelihood ratio (NPC) of each of them. They are presented with their 95% confidence intervals (CI). Results: Thirty-one patients were included and 183 measurements were performed. 49 (27%) measurements showed a painful response according to the BPS. We obtained an AUC of 0.885 (95% CI 0.830-0.940). The PDR value with the best diagnostic efficacy was 11.5%, which had a sensitivity of 89.8% (95% CI 78.2-95.6) and a specificity of 78.4% (95% CI 70.6-84.5) with an accuracy of 81.4 (75.2-86.4). The agreement between BPS and PDR had a kappa index of 0.6. Conclusions: Pupillometry could be a valid alternative for identifying pain in analgosedated critical patients. Trial registrationPhase 1 of the project PUPIPAIN ClinicalTrials.gov Identifier: NCT04078113
Risk Factors for Large-Volume Lymph Node Metastasis in Papillary Thyroid Carcinoma: A Meta-Analysis
Authors: Wu Fan , Zhou Tian-han , Pan Ting , Lu Kai-ning , Ni Ye-qin , Zhao Ling-qian , Jiang Ke-cheng , Luo Ding-cun
Published: September 2021

Background We defined large-volume lymph node metastasis (L-VLNM) as more than five lymph node metastases (LNMs) or any lymph node with a diameter of 2 mm or greater in any case of papillary thyroid cancer (PTC). This study investigated risk factors for the development of L-VLNM in PTC with meta-analysis.Methods Articles published until July 2021 on clinicopathological factors of L-VLNM in PTC were searched in electronic databases (PubMed, Web of Science (WOS), Embase, Cochrane, Wanfang Data and Chinese National Knowledge Infrastructure (CNKI)) to identify studies based on predefined criteria. Statistical analysis was performed using STATA 14.0. The outcomes were clinical and pathologic factors for L-VLNM, and the individual and pooled odds ratios (ORs) with 95% confidence intervals (CIs) of each outcome were analysed by fixed-/random-effects models. Egger’s test was used to assess publication bias in the publications. This study is registered with PROSPERO (CRD 42020213831).Results Twelve studies included 10806 patients in total. Meta-analysis revealed that an increased risk of L-VLNM was associated with male sex (OR=2.20, 95% CI=1.63–2.97, P<0.001), age<45 years (OR=2.34, 95% CI=1.36–4.02, P<0.001), tumour diameter>1 cm (OR=3.99, 95% CI=3.45–4.62, P<0.001), extrathyroidal extension (OR=2.42, 95% CI=1.90–2.82, P<0.001), capsule invasion (OR=3.62, 95% CI=1.44–9.06, P<0.001) and multifocality (OR=2.02, 95% CI=1.47–2.77, P<0.001). Hashimoto’s thyroiditis (HT; OR=0.82, 95% CI=0.60–1.11, P=0.03) was not associated with L-VLNM.Conclusions Male sex, age <45 years, tumour diameter >1 cm, extrathyroidal extension, capsule invasion and multifocality were risk factors for L-VLNM, HT was not a risk factor.
Primary Abdominal Cocoon with Right Intra-Abdominal Cryptorchidism: A Case Report
Authors: Jiao Jian , Li Han , Dong Kangdi , Liu Jin , Zhang Ronghua , Xiao Kun , Kong Shuai , Tian Shubo , Zhang Zheming , Shang Liang , Li Leping
Published: September 2021

Background: Primary abdominal cocoon is a special peritoneal disease and easily cause misdiagnosis and mistreatment. Few cases have been reported primary abdominal cocoon with intra-abdominal cryptorchidism in the literature.Case presentation: We admitted one case of a 41-year-old male patient with primary abdominal cocoon and right intra-abdominal cryptorchidism. The main symptom of this patient was intermittent abdominal pain for more than one month, preoperative CT results showed that part of the small intestine folded into a mass, which was suspected of abdominal cocoon. Part of the small intestine was wrapped by fibrous membrane and the right testicle were observed in the abdominal cavity during the operation. Intestinal adhesion release and right cryptorchidectomy were performed successfully. Pathological results revealed that the membranous material was fibrous connective tissue with chronic inflammatory cell infiltration and no spermatogenic cells and sperm were observed in the seminiferous tubules of the testicular tissue. Conclusion: This article reports one case of primary abdominal cocoon with right intra-abdominal cryptorchidism. Primary abdominal cocoon lacks specific clinical manifestations, part of patients may have cryptorchidism and the diagnosis is difficult. We should improve the understanding of primary abdominal cocoon to better save the life of patient.
Prediction of Death After Multiple Wasp Stings with a Clinical Prognostic Model
Authors: Wang Maohe , Qin Mei , Wang Amanda Y , Zhao Jia Wei , Deng Fei , Li Guisen , Wang Wei
Published: September 2021

Background: We aimed to assess the utility of the poisoning severity score (PSS) as early prognostic predictors in patients with wasp stings, and to explore a reliable and simple predictive tool for short-term outcomes.Methods: From January 2016 to December 2018, 363 patients with wasp stings in Suining Central Hospital were taken as research subjects. In the first 24h of hospital admission, the PSS and Chinese expert consensus on standardized diagnosis and treatment of wasp stings (CECC) were used as the criterion for severity classification, and their correlation was analyzed. The patients were divided into survival and death groups according to the state of discharge. The factors that affect outcome were analyzed by logistic regression analysis. A clinical prognostic model of death was constructed according to the risk factors, and 1000 times repeated sampling was done to include the data to verify the model internally.Results: The mortality of wasp sting patients was 3.9%. There was a correlation between PSS and CECC (r=0.435, P<0.001) for severity classification. Sex, age, number of stings, and PSS were independent risk factors for death. Based on the 4 independent risk factors screened by the above regression analysis, a nomogram model was constructed to predict the risk of death in wasp sting patients. The predicted value C-index was 0.962, and the internally verified AUC was 0.962(95%C.I. 0.936-0.988, P<0.001).Conclusions: PSS is helpful in the early classification of the severity of wasp stings. Sex, age, number of stings, and PSS were independent risk factors for death in wasp sting patients. The nomogram model established in this study can accurately predict the occurrence of the risk of death.
Importance of lichen and moss litters to soil carbon storage in black spruce forests on permafrost
Authors: Fujii Kazumichi , Hayakawa Chie
Published: September 2021

Aims

Climate warming is predicted to increase permafrost degradation and soil carbon (C) loss, while changes in microrelief and vegetation cover can also influence soil C storage at local scale. Black spruce forests develop lichen/moss-covered organic mounds on permafrost. Recalcitrance of lichen and moss litters, as well as cold climate, is hypothesized to increase C storage in hummocky soils.
Methods

We compared the decomposition rates of lichen and moss litters, spruce root litter, and cellulose at hummocky clayey soils, non-hummocky clayey soils, and non-hummocky sandy soils in northwest Canadian subarctic.
Results

Lichen/moss-covered hummocky clayey soils display greater C stocks than non-hummocky clayey and sandy soils. Lichen and moss litters decomposed more slowly than did spruce root litter and cellulose. Recalcitrant litter inputs of lichen and moss contribute to greater C stocks of hummocky clayey soils, compared to non-hummocky clayey and sandy soils. Lower temperature dependency of lichen and moss litter decomposition, compared to vascular plant litter, suggests stronger resistance of lichen and moss litters to decomposition.
Conclusion

Permafrost degradation by climate warming would reduce hummocky microrelief covered by lichen and moss, major contributors to soil C, and decrease the high potential for C storage of black spruce forests on permafrost.
Analysis of Prognostic Relevance based on Ambulatory Vital Signs Among Pregnancy with Pulmonary Hypertension in the ICU
Authors: Liu Renhuai , Zheng Ziyu , He Chen , Lei Chong , Chen Yu , Fang Zongping , Zhang Haopeng , Lu Zhihong , Nie Huang , Liang Dongyan , Tang Jun , Ma Xiangdong , Yang Hong , Zhang Xijing , Su Binxiao
Published: September 2021

Purpose: The study seeks to utilise the extensively monitored data to explore the prognostic information in the continuous ambulatory vital signs of the pregnant women with pulmonary hypertension in the ICU, aiming to bring insights to physicians on evaluation and management of these specific patients. Methods: This is a retrospective study of consecutive obstetric patients with PH admitted to ICU of the First Affiliated Hospital of Air Force Military Medical University of China, from January 2011 to May 2020. 92 cases are analysed via time-dependent Cox regression to take account of the dynamic features of vital signs. Results: Seven out of 92 maternal deaths occurred, with most maternal deaths occurring within the first three days of admission to the ICU. The vital signs for the survived are more stable and normally ranged comparing to the death. Three vital signs are identified as risk factors in the maternal in-hospital mortality model: SpO 2 (OR,0.93;95%CI,0.89-0.98), Heart rate(OR, 0.95 ; 95%CI, 0.92-0.99), Mean blood pressure(OR, 1.1 ; 95%CI, 0.98-1). The model performance is justified by the ROC curve with AUC being 0.84. Further exploration showed that the total and the longest consecutive time ratios also affect the outcome. Conclusions: Pregnancy women with PH who dead in hospital experienced long-term abnormal fluctuations in blood pressure, heart rate and blood oxygen during ICU stay. Both dynamic and time ratios reported impacts relating to SpO 2 , heart rate and blood pressure. In general SpO 2 mitigate the hazard. Effects of the heart rate and mean blood pressure should be described combining the time ratios of hypotension and tachycardia.
Differential expression of long noncoding RNAs in SDF-1α-induced dental pulp stem cells
Authors: xiao min , Yao Bo , Mei Xiaohan , bai yu , Wang Jueyu , Yu Qing
Published: September 2021

Background

SDF-1α cotreatment was shown to have synergistic effects on BMP-2-induced odontogenic differentiation of human apical dental papillary stem cells (SCAP) both in vitro and in vivo. Long noncoding RNAs (lncRNAs) have an important role in the odontogenic differentiation of dental pulp stem cells (DPSCs).
Methods

We examined the altered expression of lncRNAs in SDF-1α-induced odontogenic differentiation of DPSCs by lncRNA microarray and quantitative reverse transcription polymerase chain reaction (qRT-PCR) analyses. Alterations in lncRNA expression during odontogenic differentiation of DPSCs were identified. Moreover, bioinformatic analysis [Gene Ontology (GO) analysis and coding-noncoding gene coexpression (CNC) analysis] was conducted to predict the interactions of lncRNAs and identify core regulatory factors in SDF-1α-induced odontogenic differentiation of DPSCs.
Results

The microarray analysis identified 206 differentially expressed lncRNAs (134 lncRNAs with upregulated expression and 72 with downregulated expression) at 7 days post‑treatment. The data demonstrated that one lncRNA, AC080037.1, regulates SDF-1α-induced odontogenic differentiation of DPSCs. Our data showed that lncRNA AC080037.1 siRNA suppresses DPSCs migration and the expression of Rho GTPase induced by SDF-1α. Moreover, AC080037.1 knockdown significantly affected SDF-1α- and BMP-2-induced mineralized nodule formation and strongly suppressed Runt-related factor-2 (RUNX-2), DMP-1 and DSPP expression in DPSCs.
Conclusions
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Evaluation of lncRNA FOXD2-AS1 expression as a diagnostic biomarker in CRC
Authors: Shalmashi Hooman , Safaie Sahar , Shanehbandi Dariush , Asadi Milad , Bornehdeli Soghra , Navaz Abdolreza Mehdi
Published: September 2021

Background

Colorectal cancer (CRC) is still considered one of the prevalent cancers worldwide. Investigation of potential biomarkers for early detection of CRC is essential for the effective management of patients using therapeutic strategies. Considering that, this study was aimed to examine the changes in lncRNA FOXD2-AS1 expression through colorectal tumorigenesis.
Material and Methods

Fifty CRC tumor tissues and fifty adjacent normal tissue samples were prepared and involved in the current study. Total RNA was extracted from the samples and then reverse transcribed to complementary DNA. Next, the expression levels of lncRNA FOXD2-AS1 were evaluated using real-time PCR in CRC samples compared to normal ones. Also, receiver operating characteristic curve (ROC) analysis was used to evaluate the diagnostic value of FOXD2-AS1 for CRC.
Results

The obtained results showed that the expression level of FOXD2-AS1 gene was significantly (p < 0.0001) up-regulated in tumor tissues compared to normal marginal tissues. Also, a significant correlation was observed between higher the expression of FOXD2-AS1and the differentiation of tumor cells. Furthermore, ROC curve analysis estimated an AUC value of 0.59 for FOXD2-AS1, suggesting its potential as a diagnostic target.
Conclusion

Taken together, the current study implied that tissue-specific upregulation of lncRNA FOXD2-AS1 might be appropriate diagnostic biomarkers for CRC. Nonetheless, m studies are needed to validate these results and further illustrate FOXD2-AS1 function through colorectal tumorigenesis.
Optimization of the qPCR temperature profile is essential for efficient and rapid detection of Sars-CoV-2
Authors: Salamon Pál , Bálint Emese , Tar Gyöngyi , Albert Beáta
Published: September 2021

qPCR protocols should specify shorter annealing and extension times to optimize the efficacy of the target product. These specific times must be long enough for the complexes to form at the correct binding site, but if these times are too long, it can result in unspecified products. Our results show that reducing the reaction time during the second cycle can increase the specificity of the resulting product and thus reduce the total reaction time. The overall temperature profile, optimized for the target gene, shortens the detection time, allowing faster and more specific detection of the presence of the Sars-CoV-2.
Electricity consumption of drying and the effect of the dryer and temperature on the chemical quality of nettle leaves (Urtica dioica L.), birch leaves (Betula pendula, Betula pubescens) and roseroot (Rhodiola rosea L.)
Authors: Isosaari Eveliina , Väisänen Jaana , Favén Leena
Published: September 2021

Drying can constitute the majority of the energy costs and thus, manufacturing costs, in plant refining. The use of higher drying temperatures accelerates drying and reduces total electricity consumption. However, higher drying temperatures can also reduce the chemical quality of plants, as heat sensitive compounds can degrade or evaporate. The purpose of the study was to find the optimum drying temperature for nettle leaves (Urtica dioica L.), white and silver birch leaves (Betula pubescens, Betula pendula) and roseroot (Rhodiola rosea L.) in terms of electricity consumption and quality. Selected plants were dried with drying oven, convective dryer and vacuum dryer between 40 and 80 °C. The quality was determined by measuring total polyphenol content, antioxidant capacity and active compounds of roseroot. The lowest total electricity consumption was obtained by drying oven, but the highest chemical quality was obtained by vacuum dryer. The optimum drying temperature varied between 65 and 80 °C.
Graphene spin-coated electrode for polyacrylonitrile acoustic nanogenerators
Authors: Aghayari Sedigheh
Published: September 2021

In recent years piezoelectric nanogenerators, due to their more durability in high dust or humidity are more attractive than triboelectric ones. So, increasing their outputs is the subject of much researches. I focused on electrodes of the acoustic nanofibers nanogenerators for the first time. Here, I introduced a new electrode that is cheaper and does not result in lower outputs. Here for the first time graphene spin-coated ink was used for polyacrylonitrile-based acoustic nanogenerator. The results of the tests compared with the in-situ synthesis of nickel nanoparticles on the layer and using graphene spin-coated screen ink and conductive tapes. Finally, producing sound by this graphene ink was done too.
Selected ‘Starter Kit’ energy system modelling data for Peru (#CCG)
Authors: Cannone Carla , Allington Lucy , Pappis Ioannis , Barron Karla Cervantes , Usher Will , Pye Steve , Howells Mark , Walker Miriam Zachau , Ahsan Aniq , Charbonnier Flora , Halloran Claire , Hirmer Stephanie , Taliotis Constantinos , Sundin Caroline , Sridha Vignesh , Ramos Eunice , Brinkerink Maarten , Deane Paul , Gritsevskyi Andrii , Moura Gustavo , Rouget Arnaud , Rogner Holger , Quirós-Tortós Jairo , Angulo-Paniagua Jam
Published: September 2021

Energy system modelling can be used to assess the implications of different scenarios and support improved policymaking. However, access to data is often a barrier to energy system modelling, causing delays. Therefore, this article provides data that can be used to create a simple zero order energy system model for Peru, which can act as a starting point for further model development and scenario analysis. The data are collected entirely from publicly available and accessible sources, including the websites and databases of international organizations, journal articles, and existing modelling studies. This means that the dataset can be easily updated based on the latest available information or more detailed and accurate local data. These data were also used to calibrate a simple energy system model using the Open Source Energy Modelling System (OSeMOSYS) and two stylized scenarios (Fossil Future and Least Cost) for 2020–2050. The assumptions used and results of these scenarios are presented in the appendix as an illustrative example of what can be done with these data. This simple model can be adapted and further developed by in-country analysts and academics, providing a platform for future work.
Analysis of long-term climatic changes at Hodeidah-Yemen during the period between 1984 and 2019
Authors: Iraqi Abkar Ali , AbdAlla AbdAlla Mohammed
Published: September 2021

Yemen is one of the Arab country that is vulnerable to climate changes, and this is clear from the indicators of impact on water resources, coastal zone environments, etc. This work focuses on studying the climatic variability at Hodeidah city-Yemen during the period between 1984 and 2019. This study aimed to characterize trends in mean monthly, seasonal and annual temperature. To attain these objectives the collected data were analyzed using both parametric (linear regression) and non-parametric (Mann–Kendall, Spearman and Sen's slope estimator tests) methods to detect the trend and the magnitudes of rates of changes of temperature over time. Analysis of data indicates clear climatic fluctuations of temperature. The annual means of temperature during the period of study were varied between 26.9°C and 30.1°C. The warmest years were observed during the more recent years of the study period ( 2005 to 2018). The increasing rate of annual temperature is about + 0.075°C /year, + 0.37°C/5year, + 0.75°C/decade ,+2.53°C, over the whole period of study(1985 to 2019), + 3.7°C/50 year and increase to + 4.85°C in 2050. On a monthly timescale, there are similar magnitudes of rates of change from December to September with highest rates in October and November. The results also showed that most months and seasons have significant positive trends in temperature and (Z-α/2) values of the MK Test > 1.96 and positive value of Sen’s slope estimator indicates significant an increasing trend towards warmer years. Anomalies of temperature confirm significant increasing trends towards warmer years (2000s to 2019).
Complicated Meckel’s Diverticulum: lessons learnt from a case series of a single institution.
Authors: Duci Miriam , Codrich Daniela , Boscarelli Alessandro , Guida Edoardo , Miglietta Marta , Scarpa Maria-Grazia , Olenik Damiana , Leo Grazia Di , Murru Flora-Maria , Schleef Jurgen
Published: September 2021

The aim of our study is to share a single pediatric institution’s experience with complicated Meckel’s diverticulum. The clinical records of a series of 15 cases treated between January 2006 and December 2020 were reviewed. Patients were divided according to the presenting symptoms (obstructive versus painful bleeding) and subcategorised according to demographic details, intraoperative findings, surgical technique, histological examination and length of stay. Patients older than 17 years of age were excluded from the study. Males were more prone to present with complicated Meckel’s diverticulum than females, and obstructive symptoms were the most frequent presentation (60%). Median age at presentation was 9 years. The surgical technique of choice was an explorative laparoscopy in 12 cases, even though 25% of patients required conversion to laparotomy. There was no statistically significant difference between groups in terms of length of stay. Results are discussed with reference to current literature.
Employee Turnover and Job Satisfaction: A synthesis of Factors influencing employee turnover in Institutions of Higher Learning in Ghana
Authors: Mumin Alhassan Abdul , Achanso Adams Sulemana , Mordzeh-Ekpampo Musah Ibrahim , Boasu BismarkYeboah , Dei David
Published: September 2021

Turnover among teaching staff in our universities are mostly due to dissatisfaction with their jobs. Employee job satisfaction is of utmost importance to stimulating and sustaining the interest of the individual in order to prevent employee turnover. There are many factors influencing employee job satisfaction and preventing employee turnover. Factors such as salary, working conditions, cordial relationship with colleagues at work, opportunities for job progression among several other factors. The objective of this paper was to explore the extent to which these factors, affect employee job satisfaction and prevent turnover among lecturers in the University for Development Studies using the cross-sectional design and quantitative approach of data collection. Survey questionnaires were employed as data collection instruments to elicit information from 287 lecturers recruited from the University for Development Studies within the Tamale Metropolis. Multiple regression was used to establish the effect factors influencing job satisfaction had on employee turnover. Major findings from the study alluded to the fact that salary, working conditions, working environments, carrier advancement, relationship with co-workers have significant correlation with job satisfaction and employee turnover of lecturers in this institution. On account of these findings, this paper suggests yearly salary adjustments, creates a conducive working environment for lecturers, improve upon infrastructural facilities and facilitates carrier advancement issues for lecturers so as to prevent them from exiting the institution.
DEL ENFRENTAMIENTO A LA ACOGIDA A LAS MUJERES VÍCTIMAS DE VIOLENCIA DOMÉSTICA: movimientos, avances y desafíos de la política pública.
Authors: Barros Jones Nogueira , Oliveira Anna Gabriella Martins
Published: September 2021

O artigo visa analisar a política pública voltada às mulheres vitimizadas pela violência doméstica. Busca-se compreender como a gestão pública vem implementando ações no atendimento da demanda. Especificamente, o artigo foca atenção no serviço de assistência multidisciplinar Parápaz Mulher (PPM) prestado pela Fundação Parápaz, no município de Belém, capital do estado do Pará, desvelando os avanços e desafios na implementação da política pública. Trata-se de um estudo qualitativo descritivo exploratório. Para tanto, faz-se necessário o exame em documentos de domínio público, em especial a Lei Maria da Penha, promulgada no ano de 2006, bem como entrevistas com profissionais que atuam no atendimento às mulheres. O estudo no campo empírico revelou que o município de Belém apresenta boa infraestrutura de acolhimento à mulher constituída pela Rede de Proteção intersetorial e multidisciplinar, mas que carece de ampliação na prestação dos serviços. No campo teórico contribui para a compreensão da implementação nas políticas públicas de acolhimento às mulheres vítimas de violências domésticas e aponta para intersetorialidade como articulação de saberes técnicos à superação da fragmentação e à articulação das políticas públicas.
MORADIAS PARA PESSOAS COM DEFICIÊNCIA NO BRASIL
Authors: Poppe Flavia
Published: September 2021

O direito a moradias para pessoas com deficiência é assegurado pela lei brasileira. É um direito difícil de ser assegurado, pois existe um imenso desafio entre a situação na qual o país se encontra e o nível que se deseja alcançar. Apresentamos, neste artigo, um conjunto de argumentos com base em revisão de literatura e na experiência do Instituto XXX, o qual foi criado para promover autonomia e vida independente para pessoas com deficiência por meio do modelo de moradias independentes. Utilizamos conceitos internacionais sobre dois tipos de modelos de moradias para pessoas com deficiência: o coletivo e o individual. Sobre essa base, apresentamos a experiência dos diálogos com famílias, pessoas com deficiência e representantes de diferentes instâncias de governo, para sugerir a hipótese de que a cultura da família brasileira – que acredita que o melhor cuidado a ser dado a um filho com deficiência é o de sua mãe e, na sua ausência, por outro familiar – reforça a ausência de políticas públicas, gerando um círculo vicioso e comprometendo o caráter de urgência para suprir a falta de opções de moradias para permitir que esse direito seja exercido.
Quenches in initially coupled Tomonaga-Luttinger Liquids: a conformal field theory approach
Authors: Ruggiero Paola , Calabrese Pasquale , Foini Laura , Giamarchi Thierry
Published: September 2021

We study the quantum quench in two coupled Tomonaga-Luttinger Liquids (TLLs), from the off-critical to the critical regime, relying on the conformal field theory approach and the known solutions for single TLLs.
We consider a squeezed form of the initial state, whose low energy limit is fixed in a way to describe a massive and a massless mode, and we encode the non-equilibrium dynamics in a proper rescaling of the time.
In this way, we compute several correlation functions, which at leading order factorize into multipoint functions evaluated at different times for the two modes.
Depending on the observable, the contribution from the massive or from the massless mode
can be the dominant one, giving rise to exponential or power-law decay in time, respectively.
Our results find a direct application in all the quench problems where, in the scaling limit, there are two independent massless fields:
these include the Hubbard model, the Gaudin-Yang gas, and tunnel-coupled tubes in cold atoms experiments.
Aktív szurkolók csoportos súlykezelési és egészséges életmódot nyújtó programja topfight labdarúgóklubokban
Authors: Németh Boglárka , Gyócsiné Varga Zsófia , Kopkáné Plachy Judit , Fritz Péter
Published: September 2021

Célkitűzés: Az Európai Futball Fejlődésért Hálózat (EFDN) által koordinált Aktv Szurkolók Program egy futball alapú egészségügyi program. A labdarúgás iránt érdeklődésük révén vonja be résztvevőit a projekt az életmódváltásba. A program hatékonyságát mérem fel Magyarországon az FTC szurkolóinak körében. Adatok és módszerek: Intervenciót végeztünk a 12 hetes programunkban (n=26 fő) 35-60 év közöt heterogén csoporton, akik kizárólag ferencvárosi szurkolók lehetek. Kutatásunkat a Fradi sportelepén 2020-ban végeztük. Objektv méréseink: InBody 770, derékkörfogat- és vérnyomásmérés. Kérdőív: Warwick-Edinburgh (WEMWBS), életmódbeli változásaikat az aktv szurkolók számára készítet életmód kérdőívvel mértük fel. Statsztkai próbák: T-próba, Páros T-próba. Tudományos és Kutatás Etkai Bizotság által kiadot engedélyének száma: BORS-11/2020 Eredmények: A szurkolók 12 heti aktivitás és a táplálkozásuk alapismereteinek bővítése hatására a program végére jelentős változásokat tudtak elérni. A testsúly változása „Teljes fogyás” értéke a (1-12. hét között) M=-4,78±3,039kg; a párosított mintás t-próba eredménye t=8,019; p=,000. Centrális elhízás tekintetében is bizonyítható a projekt hatékonysága. Mely szerint a „Derékkörfogat változása” M=-7,538±2,921cm; a Párosított mintás t-próba eredménye t=13,155; p=,000. Javult a szisztolé (-8,65±1,137 Hgmm; t=2,915; p=,007) és a diasztolés érték is (-5,192±2,295 Hgmm; t=2,262; p=033). Következtetések: Sikeres volt a program konvertálása az FTC színeibe, amely a magyar irányelveknek is megfelel. Összességében elmondhatjuk, hogy a szurkolók eredményei szignifkáns javulást mutatnak a testösszetételben, a táplálkozási szokásokban, jóllétükben.
A textilművészet többdimenziós rekreációs hatásai
Authors: Nagy Regina , Magyar Márton
Published: September 2021

Az őskortól jelen lévő művészetek, az artsztka a kreatvitás, önkifejezés eszközei. Tevékenységei közé tartozik például a kötés, szövés, horgolás, de a ruhatervezés is. A rekreáció síkjainak megfelelően test, lelki, szellemi, szociális hatásokkal bírnak a textllel kapcsolatos aktv és passzív formák. Kutatásunk eredményei alapján a textllel kézműveskedés a fow-érzet kialakulását is elősegít, valamint a stresszkezelés hatékony eszköze.