bluuebunny/crossref_metadata_2025 huggingface dataset:
The lipid raft hypothesis revisited – New insights on raft composition and function from super‐resolution fluorescence microscopy
Authors: Owen Dylan M. , Magenau Astrid , Williamson David , Gaus Katharina
Published: June 2012

Recently developed super‐resolution microscopy techniques are changing our understanding of lipid rafts and membrane organisation in general. The lipid raft hypothesis postulates that cholesterol can drive the formation of ordered domains within the plasma membrane of cells, which may serve as platforms for cell signalling and membrane trafficking. There is now a wealth of evidence for these domains. However, their study has hitherto been hampered by the resolution limit of optical microscopy, making the definition of their properties problematic and contentious. New microscopy techniques circumvent the resolution limit and, for the first time, allow the fluorescence imaging of structures on length scales below 200 nm. This review describes such techniques, particularly as applied to the study of membrane organisation, synthesising newly emerging facets of lipid raft biology into a state‐of‐the art model.

Editor's suggested further reading in BioEssays: Super‐resolution imaging prompts re‐thinking of cell biology mechanisms Abstract and Quantitative analysis of photoactivated localization microscopy (PALM) datasets using pair‐correlation analysis Abstract
EFFECTS OF NONCONTINGENT MUSIC ON VOCAL STEREOTYPY AND TOY MANIPULATION IN CHILDREN WITH AUTISM SPECTRUM DISORDERS
Authors: Lanovaz Marc J. , Sladeczek Ingrid E. , Rapp John T.
Published: June 2012

Noncontingent music has been shown to reduce engagement in vocal stereotypy in children with autism spectrum disorders, but its effects on appropriate collateral behavior remain unknown. Given that noncontingent music is typically implemented during periods of free play, clinicians may be concerned with the effects of the intervention on toy manipulation. Thus, we examined the immediate and subsequent effects of noncontingent music on engagement in vocal stereotypy and toy manipulation in four children with autism spectrum disorders by using a three‐component multiple schedule combined with a multi‐element design. The results suggest that noncontingent music (i) reduced immediate engagement in vocal stereotypy for three of four participants, (ii) never increased subsequent engagement in vocal stereotypy, and (iii) produced idiosyncratic effects on immediate and subsequent engagement in toy manipulation for two participants. The clinical implications of the results are discussed in terms of improving the treatment of vocal stereotypy using noncontingent music. Copyright © 2012 John Wiley & Sons, Ltd.
RNA‐Schalter
Authors: Wittmann Alexander , Süß Beatrix
Published: June 2012

Ein Ziel der Synthetischen Biologie ist die Entwicklung von neuen Stoffwechselwegen. Wie am Beispiel des Antimalariamittels Artemisinin gezeigt, lassen sich über Mikroorganismen interessante Substanzen für die pharmazeutische und chemische Industrie kostengünstig und ressourcenschonend herstellen. Neben den Genen sind Regulatoren essenzielle Bestandteile dieser neuen Stoffwechselwege. RNA‐Schalter stellen eine neue Klasse an solchen Regulatoren dar. Mithilfe von ligandenbindenden RNA‐Molekülen lassen sich maßgeschneiderte RNA‐Schalter für die Synthetische Biologie entwickeln.
Extremozyme
Authors: Elleuche Skander , Sahm Kerstin , Grote Ralf , Antranikian Garabed
Published: June 2012

Die weiße Biotechnologie ist ein hochaktuelles, schnell wachsendes Feld in der angewandten Forschung. Die Bedeutung von Biokatalysatoren für Prozesse in der Chemikalienherstellung, der Lebensmittel‐ und der Textilindustrie sowie im Bereich der Bioraffinerie nimmt rapide zu. Während in der Vergangenheit zumeist Enzyme aus mesophilen Mikroorganismen als Alternative in traditionell chemischen Prozessen eingesetzt wurden, verschiebt sich der Fokus des Interesses zurzeit immer mehr zugunsten von Biokatalysatoren aus extremophilen Mikroben, welche als Extremozyme bezeichnet werden. Mikroorganismen, die beispielsweise aus besonders heißen, sauren oder salzigen Habitaten isoliert wurden, beherbergen einen großen Schatz an industriell nutzbaren Extremozymen. Diese zeigen zumeist optimale Aktivität unter extremen Umweltbedingungen und sind daher für biotechnologische Anwendungen besonders interessant.
Das bakterielle Mobilom
Authors: Schumann Wolfgang
Published: June 2012

Inzwischen hat man mobile Elemente bei allen Lebewesen nachgewiesen. Sie können bei Säugetieren für bis zu 50% des Genoms codieren und bei Pflanzen bis zu 90%. Sie etablieren sich bei Bakterien als autonom‐replizierende Replicons (Plasmide und Plasmid‐Prophagen) oder sind Bestandteile von Replicons (IS‐Elemente, Transposons, konjugative Transposons, integrative und konjugative Elemente (ICEs), genomische Inseln und Integrons). Warum gibt es überhaupt noch distinkte Bakterien‐Spezies? Offensichtlich sorgen bislang noch unbekannte Mechanismen dafür, dass bestimmte speziesbildende Gene keiner Verbreitung unterliegen.
Radioaktivität – Wirkung auf die Zelle
Authors: Wickert L.
Published: June 2012

Solange es die Erde gibt, sind alle auf ihr lebenden Organismen einer natürlichen, radioaktiven Strahlung ausgesetzt. Dem Menschen gelang es durch seine Kenntnisse über den Aufbau der Materie, den natürlichen Vorgang des radioaktiven Zerfalls auf friedliche (Medizin, Energie) und militärische Weise (Atombomben) zu nutzen. Dadurch ist die künstliche, durch den Menschen geschaffene Strahlenbelastung sowie die Menge des radioaktiven “Mülls” in den vergangenen 100 Jahren erheblich gestiegen. Die Nutzung der Kernenergie zeigt sich insbesondere nach Tschernobyl (Russland) und Fukushima (Japan) nicht so beherrschbar wie zu Beginn vermutet. Ein nach wie vor ungelöstes Problem stellt die “Entsorgung” und Lagerung von radioaktiven Materialien dar. Mit der Herstellung und Nutzung radioaktiver Substanzen in großen Mengen hinterlassen wir den nachfolgenden Generationen auf Jahrtausende ein derzeit ungelöstes Problem.
Honigbienen in Entdeckerlaune
Authors: Wendler Silke
Published: June 2012

Der Fortbestand eines Bienenvolkes ist abhängig davon, dass Kundschafterbienen immer wieder neue Futterquellen und mögliche Nestplätze ausfindig machen. Eine Forschergruppe um Zhengzheng S. Liang aus Illinois hat sich der Frage gewidmet, warum manche Bienen mehr Entdeckerdrang haben als andere.
Vererbung von Fingerabdruckmerkmalen
Authors: Hauf Fabian
Published: June 2012

Fingerabdrücke sind einzigartig und dienen daher der Identifikation. Die Daktyloskopie ist stark kriminalistisch geprägt – die Frage einer Vererbung von Fingerabdruckmerkmalen wurde bisher wissenschaftlich wenig untersucht. In der Literatur findet man häufig die – nicht belegte – Hypothese, dass Fingerabdruckmerkmale durch Umgebungseinflüsse und nicht durch Genetik geprägt werden. Die vorliegende Studie beweist jedoch mit statistischen Mitteln, dass ein Einfluss der Genetik auf die Ausprägung von Fingerabdruckmerkmalen stark zu vermuten ist.
Pflanzen bereiten sich auf den abendlichen Angriff von Insekten vor
Authors: Brennicke Axel
Published: June 2012

Insekten greifen in der Dämmerung an – das kennen wir von den Mücken und treffen entsprechende Verteidigungsmaßnahmen. Doch auch Pflanzen scheinen sich auf abendliche Attacken vorzubereiten, denn ihre innere Uhr schaltet zum beginnenden Abend automatisch die chemische Abwehr an. Diese jetzt nachgewiesene Steuerung über Hormone belegt einen weiteren Vorteil der inneren Uhr und erklärt, warum viele Gene für die Verteidigung durch diese Uhr beeinflusst werden.
Übersichtsfärbung mit Hämatoxylin und Eosin (H&E)
Authors: Schrödel Andrea
Published: June 2012

Die Hämatoxylin‐Eosin‐Färbung (kurz: H&E‐Färbung) ist die bekannteste und am häufigsten genutzte Übersichtsfärbung der Histologie und wird beispielsweise in der Pathologie eingesetzt, um krankhafte Veränderungen in Gewebeproben zu untersuchen.
Resection of segment VIII for hepatocellular carcinoma
Authors: Kishi Y , Hasegawa K , Kaneko J , Aoki T , Beck Y , Sugawara Y , Makuuchi M , Kokudo N
Published: June 2012

Background

Anatomical resection of segment VIII (SVIII) is technically demanding. Only two small studies have published short-term outcomes. The aim of the present study was to evaluate short- and long-term outcomes after anatomical resection involving SVIII for hepatocellular carcinoma (HCC), and to compare long-term outcomes with those after non-anatomical resection of SVIII.

Methods

Outcomes after anatomical resection of SVIII or its subsegments for HCC were compared with those in patients who underwent primary non-anatomical resection of SVIII during the same period.

Results

A total of 154 patients underwent anatomical resection involving SVIII and 122 had non-anatomical resection. In patients undergoing anatomical resection, the preoperative indocyanine green retention rate at 15 min ranged from 2·9 to 32·2 (median 13·6) per cent, and was 10 per cent or more in 109 patients (70·8 per cent). Median duration of operation and blood loss were 378 min and 705 ml respectively. There were no postoperative deaths, but major adverse events occurred in ten patients (6·5 per cent). The cumulative 5-year recurrence-free and overall survival rates were 28·5 and 79·6 per cent, which were significantly better than rates of 19·4 and 64·8 per cent respectively after non-anatomical resection (P = 0·036 and P < 0·001).

Conclusion

Complete resection of SVIII or its subsegments can be performed safely and the long-term outcomes seem acceptable. This can be a curative procedure for HCC, especially in patients with limited liver function reserve, in whom right hepatectomy or right paramedian sectorectomy might otherwise be needed.
Topographical anatomy of the radial nerve and its muscular branches related to surface landmarks
Authors: Cho Hyejin , Lee Hye‐Yeon , Gil Young‐Chun , Choi Yun‐Rak , Yang Hee‐Jun
Published: June 2012

Understanding of the anatomy of the radial nerve and its branches is vital to the treatment of humeral fracture or the restoration of upper extremity function. In this study, we dissected 40 upper extremities from adult cadavers to locate the course of the radial nerve and the origins and insertions of the branches of the radial nerve using surface landmarks. The radial nerve reached and left the radial groove and pierced the lateral intermuscular septum, at the levels of 46.7, 60.5, and 66.8% from the acromion to the transepicondylar line, respectively. Branches to the long head of the triceps brachii originated in the axilla, and branches to the medial and lateral heads originated in the axilla or in the arm. The muscular attachments to the long, medial, and lateral heads were on average 34.0 mm proximal, 16.4 mm distal, and 19.3 mm proximal to the level of inferior end of the deltoid muscle, respectively. The radial nerve innervated 65.0% of the brachialis muscles. Branches to the brachioradialis and those to the extensor carpi radialis longus arose from the radial nerve above the transepicondylar line. Branches to the extensor carpi radialis brevis usually arose from the deep branch of radial nerve (67.5%); however, in some cases, branches to the extensor carpi radialis brevis arose from either the radial nerve (20.0%) or the superficial branch of the radial nerve (12.5%). Using these data, the course of the radial nerve can be estimated by observing the surface of the arm. Clin. Anat. 26:862–869, 2013. © 2012 Wiley Periodicals, Inc.
Maternal smoking during pregnancy and self‐reported delinquency by offspring
Authors: Ellis Lee , Widmayer Alan , Das Shyamal
Published: June 2012

Background

Several studies have reported significant positive correlations between smoking during pregnancy by mothers and the involvement of their offspring in criminal/delinquent behaviour later in life, but these findings have been described as modest and the criminality based on official conviction statistics.

Aims

We sought to verify this relationship and probe for more details on the basis of self‐reported offending among college students.

Methods

Independently completed questionnaires were collected from 6332 students and their mothers. The students provided information about their delinquent acts, if any, according to eight categories. Their mothers provided retrospective reports of their smoking habits, if any, during pregnancy.

Findings

Mothers who recalled having smoked during pregnancy were significantly more likely than non‐smoking mothers to have offspring who self‐reported engaging in some types of delinquency. This relationship was more evident for female offspring than for male offspring and was most pronounced for illegal drug use by the offspring. There was, however, no relationship between offspring offending and estimated number of cigarettes smoked by mothers, month of pregnancy when smoked or consistency of smoking throughout pregnancy.

Conclusion

Overall, our study confirms that maternal smoking during pregnancy is associated with offspring involvement in delinquency, but the lack of critical timing or dose–response relationships between maternal smoking and later offspring delinquency cast doubt on the possibility that the associations are due to teratogenic effects of tobacco smoke. Copyright © 2012 John Wiley & Sons, Ltd.
ChemInform Abstract: Crystal Structural, Magnetic, and Transport Properties of Layered Cobalt Oxyfluorides, Sr2CoO3+xF1‐x (0 ≤ x ≤ 0.15).
Authors: Tsujimoto Yoshihiro , Sathish Clastin I. , Hong Kun‐Pyo , Oka Kengo , Azuma Masaki , Guo Yanfeng , Matsushita Yoshitaka , Yamaura Kazunari , Takayama‐Muromachi Eiji
Published: June 2012

The crystal structure of the title compound is determined by neutron and synchrotron powder diffraction measurements in the temperature range 3—320 K.
ChemInform Abstract: K3NiO2 Revisited, Phase Transition and Crystal Structure Refinement.
Authors: Duris Katarina , Mueller Ulrich , Jansen Martin
Published: June 2012

Single crystals and red, microcrystalline powders of K3NiO2 are prepared from stoichiometric mixtures of KN3, KNO3, and NiO (flowing Ar, 873 K, 50 h).
ChemInform Abstract: Na11Hg52: Complexity in a Polar Metal.
Authors: Hoch Constantin , Simon Arndt
Published: June 2012

The title amalgam is a key component in the industrially important chloralkali process.
ChemInform Abstract: Morphology‐Controlled Synthesis of W18O49 Nanostructures and Their Near‐Infrared Absorption Properties.
Authors: Guo Chongshen , Yin Shu , Yan Mei , Kobayashi Makoto , Kakihana Masato , Sato Tsugio
Published: June 2012

Various morphologies of W18O49 such as nanorods, nanofibers, nanograins, nanoassembles, nanoplates, and nanoparticles, with various sizes are solvothermally synthesized using EtOH and PrOH as reaction media and WCl6, W(OEt)6, and WO3 solids, or mixtures of them as tungsten source (autoclave, 200 °C, 24 h).
ChemInform Abstract: Phosphate Doping into Monoclinic BiVO4 for Enhanced Photoelectrochemical Water Oxidation Activity.
Authors: Jo Won Jun , Jang Ji‐Wook , Kong Ki‐jeong , Kang Hyun Joon , Kim Jae Young , Jun Hwichan , Parmar K. P. S. , Lee Jae Sung
Published: June 2012

PO4‐doped BiVO4 is prepared by the urea‐precipitation method from nitric acid solutions of bismuth nitrate, ammonium vanadate, sodium phosphate, and urea (90 °C, 24 h).
ChemInform Abstract: Hypervalent Octahedral SiH62‐ Species from High‐Pressure Synthesis.
Authors: Puhakainen Kati , Benson Daryn , Nylen Johanna , Konar Sumit , Stoyanov Emil , Leinenweber Kurt , Haeussermann Ulrich
Published: June 2012

Thermodynamically stable solids M2SiH6 (M: K, Rb) are prepared from mixtures of MH and Si, or MSi using ammonia borane as hydrogen source (NaCl capsule, 4—9 GPa, 400—700 °C, 1 h).
ChemInform Abstract: Pr5F[SiO4]2[SeO3]3: Another Complex Fluoride Oxosilicate Oxoselenate(IV).
Authors: Lipp Christian , Burns Peter C. , Schleid Thomas
Published: June 2012

Pale green single crystals of the title compound are obtained together with Pr3F[SeO3]4 by reaction of Pr2O3 (produced from elemental Pr and Pr6O11), PrF3, and SeO2 using CsBr as a fluxing agent (fused silica ampules, 750 °C, 5 d).
ChemInform Abstract: Tetravalent Dysprosium in a Perovskite‐Type Oxide.
Authors: Han Donglin , Uda Tetsuya , Nose Yoshitaro , Okajima Toshihiro , Murata Hidenobu , Tanaka Isao , Shinoda Kozo
Published: June 2012

BaZr0.8Dy0.2O3 is prepared by a conventional solid state reaction method.
ChemInform Abstract: K3 [TbxEu1‐xGe3O8(OH)2] (x = 1, 0.88, 0.67, 0): 2D‐Layered Lanthanide Germanates with Tunable Photoluminescent Properties.
Authors: Wang Xi , Wang Yu , Liu Qiong , Li Yi , Yu Jihong , Xu Ruren
Published: June 2012

The title compounds are hydrothermally prepared from aqueous mixtures of GeO2, H3BO3, KOH, Eu2O3, and Tb4O7 (H2O, autoclave, 200 °C, 7 d).
ChemInform Abstract: Synthesis and Characterization of the Trisulfate Pb[S3O10] and Theoretical Analysis of H2S3O10.
Authors: Logemann Christian , Kluener Thorsten , Wickleder Mathias S.
Published: June 2012

Colorless single crystals of Pb[S3O10] are prepared by reaction of (NH4)2PbCl6 and fuming sulfuric acid (sealed glass tube, 250 °C, 24 h).
ChemInform Abstract: Chemoenzymatic Synthesis of a Mixed Phosphine—Phosphine Oxide Catalyst and Its Application to Asymmetric Allylation of Aldehydes and Hydrogenation of Alkenes.
Authors: Boyd Derek R. , Bell Mark , Dunne Katherine S. , Kelly Brian , Stevenson Paul J. , Malone John F. , Allen Christopher C. R.
Published: June 2012

The organocatalyst allows the simple allylation of aldehydes and the hydrogenation in which it participates as ligand.
ChemInform Abstract: Camphor‐Based Schiff Base Ligand SBAIB: An Enantioselective Catalyst for Addition of Phenylacetylene to Aldehydes.
Authors: Boobalan Ramalingam , Chen Chinpiao , Lee Gene‐Hsian
Published: June 2012

The ligand derived from (1R)‐camphor is an excellent catalyst for the synthesis of (R)‐propargylic alcohols from aromatic, heteroaromatic, and aliphatic aldehydes.
ChemInform Abstract: Diastereoselective Synthesis of Novel Optically Active Five Membered O‐ and N‐Heterocyclic Compounds.
Authors: Kovacs Ervin , Farkas Ferenc , Thurner Angelika , Szoelloesy Aron , Faigl Ferenc
Published: June 2012

A variety of dihydrofuran (XIV), tetrahydrofuran (IX), dioxole (III), (VII) and pyrrolidine derivatives (XII) is prepared starting from triol (I) or its partially protected analogues.
ChemInform Abstract: Copper‐Catalyzed Domino Intramolecular Cyclization: A Facile and Efficient Approach to Polycyclic Indole Derivatives.
Authors: Xia Ziming , Wang Kuo , Zheng Jiening , Ma Zheyong , Jiang Zhanguo , Wang Xiaoxia , Lv Xin
Published: June 2012

Under optimized conditions using Cu2O/DMEDA as catalyst system, dibromovinyl salicylanilides and the corresponding N‐ and S‐analogues (VII) and (X), and anilide (XIII) undergo the title cyclization to give indolo‐fused oxazine, pyrimidine, thiazine and imidazole derivatives.
ChemInform Abstract: Palladium‐Catalyzed Divergent Reactions of 1,6‐Enyne Carbonates: Synthesis of Vinylidenepyridines and Vinylidenepyrrolidines.
Authors: Zhao Shu‐Chun , Ji Ke‐Gong , Lu Lei , He Ting , Zhou An‐Xi , Yan Ru‐Long , Ali Shaukat , Liu Xue‐Yuan , Liang Yong‐Min
Published: June 2012

Treatment of enyne carbonates like (I) and (VI) with PdI2/P(2‐furyl)3 allows a new access to vinylidenepyridines.
ChemInform Abstract: Sulfonic Acid‐Catalyzed Autoxidative Carbon—Carbon Coupling Reaction under Elevated Partial Pressure of Oxygen.
Authors: Pinter Aron , Klussmann Martin
Published: June 2012

The benzylic C—H bonds of xanthene, acridanes, isochromane and related heterocycles can be activated at 5—10 bar partial pressure of oxygen in the presence of TfOH or MesOH as catalysts to react with nucleophiles including ketones, 1,3‐dicarbonyl compounds, aldehydes, and electron‐rich arenes.
ChemInform Abstract: Natural Deep Eutectic Salt Promoted Regioselective Reduction of Epoxides and Carbonyl Compounds.
Authors: Azizi Najmadin , Batebi Elham , Bagherpour Said , Ghafuri Hossein
Published: June 2012

A 1:2 mixture of cholin chloride and urea acts as both reaction media and green catalyst for the regio‐ and chemoselective reduction of aldehydes, ketones, and epoxides with NaBH4 in the presence of other reducible functional groups.
ChemInform Abstract: Highly Efficient Nickel(II) Chloride/Bis(tricyclohexylphosphine)nickel(II) Chloride‐Cocatalyzed Hydrodefluorination of Fluoroarenes and Trifluorotoluenes with Superhydride.
Authors: Zhao Wenwen , Wu Jingjing , Cao Song
Published: June 2012

Both aromatic C—F bonds and benzylic C—F bonds are converted to C—H bonds by use of the title equimolar catalyst mixture.
ChemInform Abstract: Enantiodivergent and γ‐Selective Asymmetric Allylic Amination.
Authors: Wang Jianmin , Chen Jie , Kee Choon Wee , Tan Choon‐Hong
Published: June 2012

Various β,γ‐unsaturated thioacids are subjected to the title reaction in the presence of the bicyclic guanidine catalyst BCG.
ChemInform Abstract: An Expedient Pd/DBU Mediated Cyanation of Aryl/Heteroaryl Bromides with K4[Fe(CN)6].
Authors: Zhang Dengyou , Sun Haifeng , Zhang Lei , Zhou Yu , Li Chunpu , Jiang Hualiang , Chen Kaixian , Liu Hong
Published: June 2012

The reaction is carried under mild and green conditions in the absence of other ligands.
ChemInform Abstract: Asymmetric Addition of a Nitrogen Nucleophile to an Enoate in the Presence of a Chiral Phase‐Transfer Catalyst: A Novel Approach Toward Enantiomerically Enriched Protected β‐Amino Acids.
Authors: Weiss Markus , Borchert Sonja , Remond Emmanuelle , Juge Sylvain , Groeger Harald
Published: June 2012

A variety of chiral ammonium‐ and phosphonium‐based phase‐transfer catalysts is tested in the enantioselective aza‐Michael addition of nitrogen nucleophile (II) to alkyl enoate (II) as acceptor.
ChemInform Abstract: p‐Sulfonic Acid Calix[n]arenes as Homogeneous and Recyclable Organocatalysts for Esterification Reactions.
Authors: Fernandes Sergio Antonio , Natalino Ricardo , Rodrigues Gazolla Poliana Aparecida , da Silva Marcio Jose , Jham Gulab Newandram
Published: June 2012

Calixarenes (I) and (II) allow a significant improvement in product yields They are comparable or even superior to known acid catalysts and the additional use of an metal‐based catalyst can be avoided.
ChemInform Abstract: Rhodium Dinaphthocyclooctatetraene Complexes: Synthesis, Characterization and Catalytic Activity in [5 + 2] Cycloadditions.
Authors: Wender Paul A. , Lesser Adam B. , Sirois Lauren E.
Published: June 2012

The synthesis of dinaphthylcyclooctatetraenes and novel cationic Rh‐complexes derived therefrom is described.
ChemInform Abstract: Synthesis of Allenes via Gold‐Catalyzed Intermolecular Reaction of Propargylic Alcohols and Aromatic Compounds.
Authors: Xu Cheng‐Fu , Xu Mei , Yang Liu‐Qing , Li Chuan‐Ying
Published: June 2012

Complex AUC can be used for the construction of di‐, tri‐, and tetrasubstituted allene structures.
ChemInform Abstract: Aryne Insertion into I—I σ‐Bonds.
Authors: Rodriguez‐Lojo Diego , Cobas Agustin , Pena Diego , Perez Dolores , Guitian Enrique
Published: June 2012

An excess of fluoride with respect to iodine is required to produce various aromatic o‐diiodoarene products.
ChemInform Abstract: Regioselective Iodination of Aromatic Compounds with Potassium Iodide in the Presence of Benzyltriphenylphosphonium Perchlorate.
Authors: Albadi Jalal , Abedini Masoumeh , Iravani Nasir
Published: June 2012

The process is advantageous with regards to good selectivity between ortho‐ and para‐positions and high yields.
ChemInform Abstract: Copper‐Catalyzed Nitration of Arylboronic Acids with Nitrite Salts under Mild Conditions: An Efficient Synthesis of Nitroaromatics.
Authors: Yan Guobing , Zhang Ling , Yu Jian
Published: June 2012

The reaction of arylboronic acids with nitrite salts under mild conditions yields the corresponding nitro aromatics by substitution of the B(OH)2 group.
ChemInform Abstract: Catalyst‐Free Efficient Aza‐Michael Addition of Azoles to Nitroalkenes.
Authors: Wu Yinuo , Wang Jun , Li Pengfei , Kwong Fuk Yee
Published: June 2012

The simple procedure allows the addition of pyrazoles and indoline to β‐nitrostyrenes to afford the adducts in good excellent yields.
ChemInform Abstract: Rapid Synthesis of Homoallylic Alcohols from Aldehyde with Allyltributylstannane under Solvent‐Free Conditions.
Authors: Bora Pranjal P. , Sema H. Atoholi , Wahlang Barisha , Bez Ghanashyam
Published: June 2012

A very easy and rapid method for the synthesis of the title compounds (III) and (V) with an highly efficient recyclable and reusable catalyst and with a simple purification process is presented.
ChemInform Abstract: Direct and Selective Conversion of Benzyl Bromides to Benzaldehydes with Aqueous H2O2 Without Catalyst.
Authors: Patil Rajendra D. , Adimurthy Subbarayappa
Published: June 2012

H2O2 is used as oxidative agent for the oxidation of benzyl bromides to the corresponding aromatic aldehydes.
ChemInform Abstract: Synthesis, Characterization, and Tuberculostatic Activity of Novel 2‐(4‐Nitrobenzoyl)hydrazinecarbodithioic Acid Derivatives.
Authors: Gobis Katarzyna , Foks Henryk , Augustynowicz‐Kopec Ewa , Napiorkowska Agnieszka , Szczesio Malgorzata , Olczak Andrzej , Glowka Marek L.
Published: June 2012

Reaction of nitrobenzhydrazides (I) with carbon disulfide (II) and alkyl halides (III) in the presence of triethylamine affords a novel series of dithioacetals (IV), (VI) and thioesters (V), (VIII), depending on the amount of reagents used.
ChemInform Abstract: Simple and Efficient One‐Pot Synthesis of Nitriles from Amides and Oximes Using in situ‐Generated Burgess‐Type Reagent.
Authors: Rappai John P. , Karthikeyan Jayakumar , Prathapan Sreedharan , Unnikrishnan Perupparampil A.
Published: June 2012

The Burgess‐type reagent is generated in situ from chlorosulfonyl isocyanate and two equivalents 1‐(2‐hydroxyethyl)piperidine in dry methylene chloride at 0‐5 °C.
ChemInform Abstract: Microwave‐Assisted Synthesis of the (E)‐α‐Methylalkenoate Framework from Multifunctionalized Allylic Phosphonium Salts.
Authors: Meier Lidiane , Ferreira Misael , Sa Marcus M.
Published: June 2012

α‐Methylalkenoic acids and esters are obtained with high E‐selectivity from a sequential base‐mediated redox reaction of phosphonium salts (III) in an aqueous medium under microwave irradiation.
ChemInform Abstract: trans‐Chloro(1‐naphthyl)bis(triphenylphosphine)nickel (II)/PCy3 Catalyzed Cross‐Coupling of Aryl and Heteroaryl Neopentylglycolboronates with Aryl and Heteroaryl Mesylates and Sulfamates at Room Temperature.
Authors: Leowanawat Pawaret , Zhang Na , Safi Mehtap , Hoffmann David J. , Fryberger Miriam C. , George Aiswaria , Percec Virgil
Published: June 2012

The reaction allows a convenient and inexpensive access to a wide range of biaryls and heterobiaryls.
ChemInform Abstract: Asymmetric Benzoylation of meso‐Hydrobenzoin Using a Reusable Tripodal Imidazoline—Pyridine—Cu Catalyst.
Authors: Arai Takayoshi , Sakagami Ken
Published: June 2012

A catalyst system generated from Cu(BF4)2 and new chiral imidazoline—pyridine ligands is used to promote the title reactions of meso‐diols (III) to afford the corresponding adducts with enantioselectivities up to 85%.
ChemInform Abstract: 3D Nanoporous FeAl‐KIT‐5 with a Cage‐Type Pore Structure: A Highly Efficient and Stable Catalyst for Hydroarylation of Styrene and Arylacetylenes.
Authors: Varghese Shaji , Nagarajan Samuthira , Benzigar Mercy R. , Mano Ajayan , AL‐Othman Zeid A. , Raj George Allen Gnana , Vinu Ajayan
Published: June 2012

The novel bimetallic silicate is synthesized and investigated as reusable catalyst for high‐yielding title reactions.
ChemInform Abstract: Palladium‐Catalyzed Dehydrative Heck Olefination of Secondary Aryl Alcohols in Ionic Liquids: Towards a Waste‐Free Strategy for Tandem Synthesis of Stilbenoids.
Authors: Kumar Rakesh , Shard Amit , Bharti Richa , Thopate Yogesh , Sinha Arun Kumar
Published: June 2012

The one‐pot approach uses inexpensive secondary alcohols as styrene source without the need of an inert atmosphere.
ChemInform Abstract: Mild Pd/Cu‐Catalyzed Sila‐Sonogashira Coupling of (Hetero)aryl Bromides with (Hetero)arylethynylsilanes under PTC Conditions.
Authors: Bellina Fabio , Lessi Marco
Published: June 2012

Symmetrical and unsymmetrical diarylethynes can be readily prepared; sterically hindered bromides and base‐labile functional groups are tolerated.
ChemInform Abstract: Tetrahydroxynaphthalene Reductase: Catalytic Properties of an Enzyme Involved in Reductive Asymmetric Naphthol Dearomatization.
Authors: Schaetzle Michael A. , Flemming Stephan , Husain Syed Masood , Richter Michael , Guenther Stefan , Mueller Michael
Published: June 2012

The reduction of polyhydroxynaphthalenes (I) and related 2‐tetralones is studied with the focus on structure—activity relationship to gain insight into the dynamics of the catalytic cycle.
ChemInform Abstract: Synthesis of 2,2′‐Diamino‐7‐tert‐butyl‐9,9′‐spirobifluorene Starting from 4,4′‐Di‐tert‐butylbiphenyl.
Authors: Xiao Haibo , Yin Hongyao , Wang Lei , Mei Chong , Zhang Xiaoying
Published: June 2012

Key step of the synthesis of the novel spirobifluorene diamine monomer (VI) is the introduction of a nitro group into the 2‐position of the spirobifluorene (IV) through the loss of tert‐butyl group at the 2‐position.
ChemInform Abstract: Gold‐Catalyzed Synthesis of Dibenzopentalenes — Evidence for Gold Vinylidenes
Authors: Hashmi A. Stephen K. , Wieteck Marcel , Braun Ingo , Noesel Pascal , Jongbloed Linda , Rudolph Matthias , Rominger Frank
Published: June 2012

Arene‐1,2‐diynes possessing one terminal and one aryl/heteroaryl‐substituted alkyne moiety are readily converted into the title polycyclic compounds.
ChemInform Abstract: Room‐Temperature B(OAc)3‐Promoted Diels—Alder Reaction of Juglone with Styrenes: Total Syntheses of Tetrangulol and Anhydrolandomycinone.
Authors: Hsu Day‐Shin , Huang Jiun‐Yi
Published: June 2012

The title reaction is generally carried out in the presence of excess alkene and reagents to provide a simple approach to benzanthracenequinone derivatives.
ChemInform Abstract: Stereoselective Synthesis of trans β‐Lactams via Palladium/N‐Heterocyclic Carbene‐Catalyzed Carbonylative [2 + 2] Cycloaddition.
Authors: Xie Pan , Qian Bo , Huang Hanmin , Xia Chungu
Published: June 2012

Reactive benzylic substrates are treated with a variety of aldimines to give the important β‐lactam scaffold with complete regio‐ and trans‐diastereoselectivity.
ChemInform Abstract: Highly Stereoselective Chemoenzymatic Synthesis of the 3H‐Isobenzofuran Skeleton. Access to Enantiopure 3‐Methylphthalides.
Authors: Mangas‐Sanchez Juan , Busto Eduardo , Gotor‐Fernandez Vicente , Gotor Vicente
Published: June 2012

Bioreduction of 2‐acetylbenzonitriles using baker′s yeast is a key step for the preparation of optically active target compounds, which are formed after acidic work‐up.
ChemInform Abstract: Intramolecular ipso‐Halocyclization of 4‐(p‐Unsubstituted‐aryl)‐1‐alkynes Leading to Spiro[4,5]trienones: Scope, Application, and Mechanistic Investigations.
Authors: Tang Bo‐Xiao , Zhang Yue‐Hua , Song Ren‐Jie , Tang Dong‐Jun , Deng Guo‐Bo , Wang Zhi‐Qiang , Xie Ye‐Xiang , Xia Yuan‐Zhi , Li Jin‐Heng
Published: June 2012

Treatment of arylated alkynes of type (I), (III), (V), and (XI) with NBS and water provides a new and general approach to spiro[4,5]trienones present in biologically active compounds.
ChemInform Abstract: Cross‐Dehydrogenative Coupling Between Enamino Esters and Ketones: Synthesis of Tetrasubstituted Pyrroles.
Authors: Zhao Miao , Wang Fen , Li Xingwei
Published: June 2012

Acetone and various analogues are suitable partners in the pyrrole formation, which can be carried out in the absence of a transition metal catalyst.
ChemInform Abstract: Asymmetric Michael Addition of α‐Substituted Isocyanoacetates with Maleimides Catalyzed by Chiral Tertiary Amine Thiourea.
Authors: Bai Jian‐Fei , Wang Liang‐Liang , Peng Lin , Guo Yun‐Long , Jia Li‐Na , Tian Fang , He Guang‐Yun , Xu Xiao‐Ying , Wang Li‐Xin
Published: June 2012

The title reaction affords succinimide derivatives having adjacent tertiary and quaternary stereocenters.
ChemInform Abstract: Rhodium‐Catalyzed Asymmetric Addition of Arylboronic Acids to Indolylnitroalkenes.
Authors: Xing Junwei , Chen Guihua , Cao Peng , Liao Jian
Published: June 2012

The method provides an efficient approach to optically pure α‐aryl‐3‐indolylnitroethanes under mild conditions.
ChemInform Abstract: Electrophilic Trifluoromethanesulfanylation of Indole Derivatives.
Authors: Ferry Aurelien , Billard Thierry , Bacque Eric , Langlois Bernard R.
Published: June 2012

Title reaction is smoothly achieved using trifluoromethanesulfinamide (II) as a less toxic alternative to CF3SCl.
ChemInform Abstract: A Way to Avoid Using Precious Metals: The Application of High‐Surface Activated Carbon for the Synthesis of Isoindoles via the Diels—Alder Reaction of 2H‐Pyran‐2‐ones.
Authors: Krivec Marko , Gazvoda Martin , Kranjc Kristof , Polanc Slovenko , Kocevar Marijan
Published: June 2012

Activated carbon Darco KB efficiently promotes the coupling of pyranones with maleimides.
ChemInform Abstract: Synthesis of Fused Isoindoles via 1,3‐Dipolar Cycloaddition of 1,3‐Oxazolium‐5‐olates (Muenchnones) with Nitro Benzazoles.
Authors: Pechenkin Sergey Yu. , Starosotnikov Aleksei M. , Bastrakov Maxim A. , Kachala Vadim V. , Shevelev Svyatoslav A.
Published: June 2012

1,3‐Dipolar cycloaddition of in situ formed muenchnones (III) to nitro benzazoles leads to azolo‐fused isoindole derivatives of type (IV), (V), or (VIII) after elimination of HNO2 and CO2.
ChemInform Abstract: Construction of Polycyclic Spiroindolines via an Intramolecular Oxidative Coupling/Cyclization Cascade Reaction Process.
Authors: Fan Feng , Xie Weiqing , Ma Dawei
Published: June 2012

In the case of substrate (V), the simple oxidative coupling product is formed as main component.
ChemInform Abstract: Intramolecular Oxidative Diamination and Aminohydroxylation of Olefins under Metal‐Free Conditions.
Authors: Kim Hyun Jin , Cho Seung Hwan , Chang Sukbok
Published: June 2012

The N‐substituent in the substrates influences the yields extremely.
ChemInform Abstract: Asymmetric Synthesis of 1,3‐Dioxolanes by Organocatalytic Formal [3 + 2] Cycloaddition via Hemiacetal Intermediates.
Authors: Asano Keisuke , Matsubara Seijiro
Published: June 2012

A wide range of optically active 1,3‐dioxolanes is prepared by organocatalytic [3 + 2] cycloaddition reaction of γ‐hydroxy‐α,β‐unsaturated ketones and aldehydes or ketones.
ChemInform Abstract: Hydrogen Halides as Nucleophilic Agents for 3,4,5‐Trinitro‐1H‐pyrazoles.
Authors: Dalinger Igor L. , Vatsadze Irina A. , Shkineva Tatyana K. , Popova Galina P. , Shevelev Svyatoslav A.
Published: June 2012

3,4,5‐Trinitro‐1H‐pyrazoles undergo nucleophilic substitution of one nitro group when treated with concentrated aqueous hydrogen halide solution.
ChemInform Abstract: Copper‐Catalyzed Synthesis of Substituted Indazoles from 2‐Chloroarenes at Low Catalyst‐Loading.
Authors: Tanimori Shinji , Kobayashi Yasuyuki , Iesaki Yasukazu , Ozaki Yuka , Kirihata Mitsunori
Published: June 2012

An efficient, general, practical, and improved synthesis of the title compounds from readily available starting materials is established and expanded to even less reactive chloroarenes.
ChemInform Abstract: Highly Efficient One‐Pot Synthesis of Trisubstituted Imidazoles under Catalyst‐Free Conditions.
Authors: Azizi Najmadin , Dado Nairreh , Amiri Alireza Khajeh
Published: June 2012

This is the first report for a catalyst‐free and very mild synthesis of imidazoles, which are generated from readily available starting materials in a facile and atom economical three‐component procedure.
ChemInform Abstract: Construction of Adjacent Spiroquaternary and Tertiary Stereocenters Through Phosphine‐Catalyzed Asymmetric [3 + 2] Annulation of Allenoates with Alkylidene Azlactones.
Authors: Wang De , Wei Yin , Shi Min
Published: June 2012

A novel axially chiral spiro‐phosphine‐catalyzed highly regio‐, diastereo‐ and enantioselective cycloaddition of azlactones (I) and allenic esters (II) is described.
ChemInform Abstract: Iodine‐Mediated Intramolecular Oxidative Cyclization of 2‐(Styrylthio)anilines: Synthesis of 2‐Substituted Benzothiazoles.
Authors: Zhao Dong‐Yun , Guo Xiao‐Kang , Li Jin‐Heng , Tang Ri‐Yuan
Published: June 2012

The novel metal‐free process affords the title compounds in moderate yields.
ChemInform Abstract: Synthesis and Anticancer Activity of 3,5‐Diaryl‐1,2,4‐oxadiazole Derivatives.
Authors: Kundu Mrityunjoy , Singh Jagadish , Singh Brijesh , Ghosh Tirtha , Maiti B. C. , Maity T. K.
Published: June 2012

The title compounds (III) are obtained by condensation of amidoximes with aromatic acid chlorides.They exhibit significant reduction of tumor cell count as well as tumor weight.
ChemInform Abstract: Chemistry of Halonitroethenes. Part 2. Trichloronitroethenes as a Building Block for the Novel Synthesis of 5‐Chloro(nitro)methyl‐Substituted 1‐Aryltetrazoles.
Authors: Zapol'skii Viktor A. , Yang Xuena , Namyslo Jan C. , Gjikaj Mimoza , Kaufmann Dieter E.
Published: June 2012

A novel synthesis of title tetrazoles (VI) and their conversion to a variety of derivatives is described.
ChemInform Abstract: Formal [4 + 2] Cycloaddition of Di‐tert‐butyl 2‐Ethoxycyclobutane‐1,1‐dicarboxylate with Ketones or Aldehydes and Tandem Lactonization.
Authors: Okado Ryohei , Nowaki Aya , Matsuo Jun‐ichi , Ishibashi Hiroyuki
Published: June 2012

SnCl4‐catalyzed formal [4 + 2] cycloaddition of the title cyclobutanedicarboxylate (I) with ketones or aldehydes affords dihydropyrandicarboxylates, whereas the Tms‐O‐Tf‐promoted reaction occurs via a tandem cycloaddition—lactonization mechanism furnishing dioxabicyclooctanecarboxylates.
ChemInform Abstract: Bifunctional Amino Squaramide Catalyzed Asymmetric Spiroannulation Cascades with Aliphatic β,γ‐Unsaturated α‐Keto Esters: Controlling an Aldehyde Enolate.
Authors: Wang Xiaoqin , Yao Weijun , Yao Zhihui , Ma Cheng
Published: June 2012

The use of squaramide BAS in the process renders possible the use of aliphatic and aromatic ester substrates to produce spirocyclic dihydropyrans or simple dihydrofurans with 3 continuous stereocenters.
ChemInform Abstract: Syntheses of Furo[3,4‐c]coumarins and Related Furyl Coumarin Derivatives via Intramolecular Wittig Reactions.
Authors: Jang Yeong‐Jiunn , Syu Siang‐en , Chen Yu‐Jhang , Yang Mei‐Chun , Lin Wenwei
Published: June 2012

The reaction of coumarins (I) with acid chlorides (II) in the presence of tributylphosphine gives rise to desired furo[3,4‐c]coumarins (III), whilst the analogous reaction of substrates (IV) and (VI) leads to furyl‐substituted coumarins (V) and (VII).
ChemInform Abstract: 1,3‐Dipolar Cycloadditions of Nonstabilized Azomethine Ylides at 3‐Substituted Coumarins: Synthesis of 1‐Benzopyrano[3,4‐c]pyrrolidines.
Authors: Moshkin Vladimir S. , Sosnovskikh Vyacheslav Ya. , Slepukhin Pavel A. , Roeschenthaler Gerd‐Volker
Published: June 2012

In situ formed azomethine ylides undergo 1,3‐dipolar cycloaddition reactions to form title compounds of type (IV), (VI) or (VIII), regio‐ and stereoselectively.
ChemInform Abstract: Ammonium Chloride‐Catalyzed One‐Pot Synthesis of Tetrahydrobenzo[α]xanthen‐11‐one Derivatives under Solvent‐Free Conditions.
Authors: Foroughifar Naser , Mobinikhaledi Akbar , Moghanian Hassan , Mozafari Reza , Esfahani Hamid R. M.
Published: June 2012

Optimum reaction conditions are examined for the three‐component condensation of aldehydes, β‐naphthols and dimedone affording title compounds of type (IV).
ChemInform Abstract: Copper‐Catalyzed Thiolation Cyclization of 1‐Chloro‐1,5‐enynes with Sodium Hydrosulfide: Synthesis of CF3‐Containing 1H‐Isothiochromenes.
Authors: Shi Shuai , Sun Lei‐Lei , Liao Zhi‐Yong , Zhang Xing‐Guo
Published: June 2012

A regio‐ and stereoselective synthesis of the title compounds is achieved by Cu(I)‐catalyzed tandem thiolation and 6‐exo‐dig heterocyclization with NaHS.
ChemInform Abstract: A “One‐Pot” Multicomponent Approach to Polysubstituted 4‐Aminopyridines.
Authors: Shao Jiaan , Yu Wanwan , Shao Zhanying , Yu Yongping
Published: June 2012

A new strategy to prepare polysubstituted 4‐aminopyridines (IV) is reported.
ChemInform Abstract: A General Solution for the 2‐Pyridyl Problem.
Authors: Dick Graham R. , Woerly Eric M. , Burke Martin D.
Published: June 2012

The cross‐coupling of air‐stable 2‐pyridyl MIDA boronates with a variety of aryl halides and triflates under conditions A) is highly efficient for the preparation of various functionalized pyridine derivatives bearing aryl substituents at position 2.
ChemInform Abstract: Reaction of Alkyl Isocyanides, Dialkyl Acetylenedicarboxylates with 4‐Hydroxy Quinoline: Synthesis of 1‐Azabuta‐1,3‐dienes.
Authors: Mohtat Bita , Rezazadeh Somayeh , Matinfar Mahnaz , Arabzadeh Vale , Djahaniani Hoorieh , Hossaini Zinatossadat
Published: June 2012

The reaction proceeds under neutral conditions without the need for catalyst or promoter.
ChemInform Abstract: Camphorsulfonic Acid Catalyzed Facile Tandem Double Friedlaender Annulation Protocol for the Synthesis of Phenoxy Linked Bisquinoline Derivatives and Discovery of Antitubercular Agents.
Authors: Paul Nidhin , Murugavel Muthuchamy , Muthusubramanian Shanmugam , Sriram Dharmarajan
Published: June 2012

A series of phenoxy linked bisquinoline derivatives (III) are synthesized using a CSA‐catalyzed tandem Friedlander annulation.
ChemInform Abstract: Molybdenum Trioxide Catalyzed Oxidative Cross‐Dehydrogenative Coupling of Benzylic sp3 C—H Bonds: Synthesis of α‐Aminophosphonates under Aerobic Conditions.
Authors: Alagiri Kaliyamoorthy , Devadig Pradeep , Prabhu Kandikere R.
Published: June 2012

Efficient α‐phosphonation of N‐aryl tetrahydroisoquinoline derivatives is achieved with elemental oxygen as the terminal oxidant.
ChemInform Abstract: Synthesis of 5,6‐Dihydrophenanthridine (DHPA) Sulfonamides and Subsequent Acid‐Catalyzed Rearrangement to Diaryl Sulfones.
Authors: Meseroll Lisa Marie Neuls , McKee James R. , Zanger Murray
Published: June 2012

The rearrangement of novel sulfonamides (I) under acidic conditions leads to diaryl sulfones, e.g. (II).
ChemInform Abstract: Multicomponent Approaches to 8‐Carboxylnaphthyl‐Functionalized Pyrazolo[3,4‐b]pyridine Derivatives.
Authors: Hao Yan , Xu Xiao‐Ping , Chen Tao , Zhao Li‐Li , Ji Shun‐Jun
Published: June 2012

A novel and efficient approach to the title pyrazolopyridine derivatives such as (IV), (VI), (VIII) is developed using a one‐pot, three‐component reaction involving acenaphthylenedione (II) and aminopyrazoles (III).
ChemInform Abstract: Microwave‐Assisted Synthesis of Indolo[2,3‐b]dibenzo[b,g][1,8]naphthyridines.
Authors: Yamuna Ezhumalai , Zeller Matthias , Prasad Karnam Jayarampillai Rajendra
Published: June 2012

A simple condensation of aminocarbazole (I) with 2‐chloro‐3‐formylquinolines allows the preparation of the synthetically and biologically important N‐heterocyclic skeleton (III).
ChemInform Abstract: First Enantioselective Syntheses of the Dopamine D1 and D2 Receptor Modulators, (+)‐ and (‐)‐Govadine.
Authors: Zhai Huimin , Miller James , Sammis Glenn
Published: June 2012

A new enantioselective synthetic route to the potential antipsychotic govadine is described.
ChemInform Abstract: Palladium‐ and Copper‐Cocatalyzed Tandem N—H/C—H Bond Functionalization: Synthesis of CF3‐Containing Indolo‐ and Pyrrolo[2,1‐a]isoquinolines
Authors: Sun Lei‐Lei , Liao Zhi‐Yong , Tang Ri‐Yuan , Deng Chen‐Liang , Zhang Xing‐Guo
Published: June 2012

a new and efficient approach to biologically important title compounds
ChemInform Abstract: 4‐Phenoxypiperidine Pyridazin‐3‐one Histamine H3 Receptor Inverse Agonists Demonstrating Potent and Robust Wake Promoting Activity.
Authors: Hudkins Robert L. , et al. et al.
Published: June 2012

A variety of piperidinyloxy(het)arylpyridazinones (VI), (VII) and (VIII) is prepared and tested for their hERG and DAT selectivity.
ChemInform Abstract: Synthesis of Fused Indazole Ring Systems and Application to Nigeglanine Hydrobromide.
Authors: Sather Aaron C. , Berryman Orion B. , Rebek Julius Jr.
Published: June 2012

The reaction is general to prepare various tricyclic pyridazino[1,2‐a]indazolium ring systems.
ChemInform Abstract: Synthesis and Antihypertensive Activity of Pyrimidin‐4(3H)‐one Derivatives as Losartan Analogue for New Angiotensin II Receptor Type 1 (AT1) Antagonists.
Authors: Kim Tae Woo , Yoo Byoung Wook , Lee Joon Kwang , Kim Ji Han , Lee Kyung‐Tae , Chi Yong Ha , Lee Jae Yeol
Published: June 2012

A series of losartan‐like pyrimidin‐4(3H)‐one derivatives (I) are synthesized and evaluated as a novel class of AT1 receptor antagonists.
ChemInform Abstract: Synthesis of 2,4‐Diaminoquinazolines and Tricyclic Quinazolines by Cascade Reductive Cyclization of Methyl N‐Cyano‐2‐nitrobenzimidates.
Authors: Yin Ping , Liu Nan , Deng Yu‐Xing , Chen Yue , Deng Yong , He Ling
Published: June 2012

The method allows an efficient access to 2,4‐diaminoquinazolines and tricyclic qinazolines.
ChemInform Abstract: Synthesis and Evaluation of Fluorinated Analogues of Monoamine Reuptake Inhibitors.
Authors: Philippe Christine , Kaffy Julia , Milcent Thierry , Bonnet‐Delpon Daniele
Published: June 2012

A variety of novel fluorinated analogues of monoamine uptake inhibitors are prepared, but they possess only low biological activity.
ChemInform Abstract: Terminal Alkynes as Keto‐Methyl Equivalent Toward One Pot Synthesis of 1,5‐Benzodiazepine Derivatives under Catalysis of Hg(OTf)2.
Authors: Maiti Gourhari , Kayal Utpal , Karmakar Rajiv , Bhattacharya Rudraksha N.
Published: June 2012

An efficient reaction of o‐phenylenediamines with terminal acetylenes is achieved under mild conditions to give benzodiazepinones (III) in moderate to good yields.
ChemInform Abstract: Advances in Drug Design and Discovery. Part 14. In vitro and in vivo Antifilarial Activity Evaluation of 3,6‐Epoxy [1,5]Dioxocines: A New Class of Antifilarial Agents.
Authors: Sashidhara Koneni V. , Kumar Abdhesh , Rao K. Bhaskara , Kushwaha Vikas , Saxena Kirti , Murthy P. K.
Published: June 2012

A series of 3,6‐epoxy[1,5]dioxocines, e.g. (III), are synthesized and evaluated for their antifilarial activity against adult parasites of human lymphatic filarial parasite Brugia malayi.
ChemInform Abstract: Synthesis of Fused Dihydropyrano(furano)pyridines via [4 + 2]‐Cycloaddition of 5‐Alkenoxy Substituted Oxazoles.
Authors: Goodman Steven N. , Mans Douglas M. , Sisko Joseph , Yin Hao
Published: June 2012

The reaction proceeds best in the presence of Tf2O and pyridine.
ChemInform Abstract: Ni‐ and Pd‐Catalyzed Synthesis of Substituted and Functionalized Allylic Boronates.
Authors: Zhang Ping , Roundtree Ian A. , Morken James P.
Published: June 2012

Different commercially available Pd catalysts can be used in the borylation process to afford the boron compounds with excellent or exclusive (E) or (Z) selectivity.
ChemInform Abstract: 1,1‐Carboboration Route to Substituted Naphthalenes.
Authors: Liedtke Rene , Harhausen Marcel , Froehlich Roland , Kehr Gerald , Erker Gerhard
Published: June 2012

Substituted bis(alkynyl)benzenes react with strongly electrophilic boranes, bearing C6F5 groups to afford densely substituted boryl‐naphthalene derivatives.
ChemInform Abstract: Rapid and Stereochemically Flexible Synthesis of Polypropionates: Super‐Silyl‐Governed Aldol Cascades.
Authors: Brady Patrick B. , Yamamoto Hisashi
Published: June 2012

The synthesis represents a highly efficient alternative to lengthy classical aldol preparations of polypropionates.
ChemInform Abstract: P—C Cross‐Coupling onto Enamides: Versatile Synthesis of α‐Enamido Phosphane Derivatives.
Authors: Cieslikiewicz Monika , Bouet Alexis , Juge Sylvain , Toffano Martial , Bayardon Jerome , West Caroline , Lewinski Krzystof , Gillaizeau Isabelle
Published: June 2012

Secondary phosphane—borane derivatives and phosphane oxide (VI) react with α‐amido enol phosphate reagents to afford new chiral or achiral tertiary α‐enamido phosphane derivatives.
ChemInform Abstract: The Asymmetric Synthesis of Chiral Cyclic α‐Hydroxy Phosphonates and Quaternary Cyclic α‐Hydroxy Phosphonates.
Authors: Wang Chubei , Xu Chao , Tan Xiaosong , Peng Hao , He Hongwu
Published: June 2012

A dialuminum complex derived in situ from chiral tridentate Schiff Base TSB in combination with silver carbonate catalyzes the addition of cyclic phosphite (II) to aldehydes or ketones to give the title phosphonates with up to 99% enantioselectivity.