bluuebunny/crossref_metadata_2025 huggingface dataset:
Protection of the obligor in administrative enforcement against realestate
Authors: Dalkowska Anna
Published: June 2023

Enforcement against real estate constitutes one of the enforcement measures applying to pecuniary obligations defined in administrative enforcement proceedings. It encroaches upon the property and personal rights of the obligor, triggering financial and legal consequences not only for the obligor concerned, but also for other persons extraneous to the enforcement, including family and household members, in the case of them using the real estate subject to enforcement for the purpose of accommodation. On the one hand it constitutes a burdensome form of enforcement for the obligor, because it applies to one of the fundamental rights protected under the Constitution, that of the property right to real estate. On the other, enforcement against real estate is costly, and does not always lead to the full satisfaction of the creditor. This is why one of the fundamental tasks placed before the legislator is to shape and ensure legal means for the obligor that would constitute a sufficient guarantee for their protection and would realise the constitutional principles of rule of law, equality, proportionality and social justice.
Acquisition of ownership by acquisitive prescription by the State Treasury or a local government unit in the light of the principle of legality (Article 7 of the Polish Constitution) contribution to the discussion
Authors: Kondek Jędrzej
Published: June 2023

The subject of this article is to analyze the consequences of rule resulting from art. 7 of the Polish Constitution for the admissibility of acquisition of property by acquisitive prescription by the State Treasury or a local government unit. There is a clear contradiction between this principle and the very essence of acquiring property by prescription. In the article it will be presented an interpretation Art. 172 of the Civil Code (relating to the acquisition of real estate by prescription) and Art. 174 of the Civil Code (relating to the acquisition by prescription of ownership of a movable property) in a way to remove the said contradiction.As a result, it should be assumed that the State Treasury can never possess a thing without a legal basis. The opposite view would mean that it may operate without a legal basis, and thus a breach of the norm under Art. 7 of the Polish Constitution. Art. 7 of the Constitution of the Republic of Poland must mean that either we will never recognize such ownership as possession, or that we believe that the possession of an item by the State Treasury may never lead to usucapion, as it would sanction behavior contrary to constitutional norms. Since the first solution would infringe the principle of treating possession as only a factual state, the second solution should be regarded as the correct one. Art. 172 of the Civil Code and 174 of the Civil Code should therefore be interpreted in accordance with Art. 7 of the Polish Constitution, and therefore the State Treasury cannot be the subject of acquisitive prescription. The same should be applied to local government units.
Sprawno funkcjonowania kierownika (dowdcy) w organizacji zhierarchizowanej
Authors: Woejszo Jarosław
Published: June 2023

Sprawno dziaania organizacji zhierarchizowanych (wojskowych, policyjnych, Pastwowej Stray Poarnej, Stray Granicznej itp.) w zasadniczej mierze jest pochodn efektywnoci pracy dowdcw (kierownikw) wszystkich szczebli. To wanie oni wskazuj cele dziaania, przydzielaj zadania podwadnym i koordynuj ich prac. Jednoczenie dysponuj oni zasobami osobowymi, rzeczowymi, finansowymi i informacyjnymi, ktre s niezbdne w trakcie wykonywania zada. Dlatego istotne wydaje si waciwe zrozumienie roli i zada, jak dowd-cy/kierownicy speniaj w organizacjach zhierarchizowanych. Konieczno podjcia tej problematyki wynika przede wszystkim ze zmiany zakresu zada oraz przemian strukturalno-organizacyjnych tyche formacji (wojsko, Policja, Pastwowa Stra Poarna). Coraz szersze spektrum zada stawianych przed wojskiem, Policj, stra poarn wymusza systematyczne modyfikacje w zakresie umiejtnoci i kwalifikacji wspczesnych dowdcw. W procesie analizy tych zmian naley uwzgldni podstawy naukowe majce rdo w dorobku teorii organizacji i zarzdzania oraz wasne rozwizania i dowiadczenia w tym obszarze. W artykule przedstawiono wybrane aspekty dotyczce roli i zada wspczesnych dowdcw (kierownikw) oraz mankamenty w organizacji pracy przez kierownika/dowdc. Std te, po okreleniu roli dowdcy, opisano jego zadania w postaci obowizkw i uprawnie. Sprawne i skuteczne dziaanie dowd-cw wymaga wykonania szeregu czynnoci oraz posiadania specyficznych umiejtnoci, dlatego logicznym dopenieniem artykuu jest opis czynnoci i umiejtnoci dowdczych. Ponadto wypeniane przez dowdcw zasadnicze funkcje oraz odgrywane role s wysoce skorelowane z podstawowymi rolami kierownikw w organizacjach cywilnych, z racji tego uwzgldniono rwnie analogie zachodzce pomidzy prac dowdcw a prac kierownikw w organizacjach cywilnych.
Ocena poznawcza i strategie radzenia sobie ze stresem a style humoru personelu instytucji resocjalizacyjnych
Authors: Karłyk-Ćwik Anna
Published: June 2023

Celem badania, przeprowadzonego w grupie 334 pedagogw resocjalizacyjnych, byo zidentyfikowanie preferowanych przez nich stylw humoru, kategorii oceny poznawczej oraz strategii radzenia sobie ze stresem z uwzgldnieniem rnic midzypciowych, a take ustalenie korelacji pomidzy tymi zmiennymi.
Policja w systemie zarzdzania kryzysowego w trakcie dziaa zwizanych z masowym niciem ryb w Odrze
Authors: Kochańczyk Rafał , Burniak Bartłomiej
Published: June 2023

Streszczenie: System zarzdzania kryzysowego i ochrony infrastruktury krytycznej naley do jednego z najbardziej istotnych elementw zabezpieczenia pastwa. Poniewa zapewnienie bezpieczestwa wymaga staego nadzorowania, niezbdne jest prowadzenie takich dziaa przez organy i instytucje administracji publicznej, aby w sposb naleyty byy one przygotowane na reakcj w sytuacjach kryzysowych. W gwnej mierze sprawne dziaanie organw pastwa uwarunkowane jest dowiadczonym aparatem administracyjnym, wypracowanymi procedurami, zaangaowaniem odpowiednich sub, inspekcji i stray. W polskim systemie zarzdzania istotn rol odgrywa wojewoda, ktry odpowiada nie tylko za stan administracji rzdowej, ale i te za faktyczne bezpieczestwo w wojewdztwie. Jednym z gwnych podmiotw, wspierajcych wojewod w tych dziaaniach, jest Policja, ktra oprcz swoich podstawowych zada w zakresie zapewnienia bezpieczestwa i porzdku publicznego posiada siy i rodki do dziaania w sytuacjach kryzysowych, spowodowanych midzy innymi katastrof naturaln czy te awari techniczn.
Medyczne i prawno-karne skutki uderze opat i szpadlem w kontekcie uznania tych przedmiotw za podobnie niebezpiecznie do broni palnej i noa w rozumieniu kodeksu karnego
Authors: Arkuszewski Piotr , Kłosiński Karol , Pasieka Zbigniew
Published: June 2023

Pojcie innego przedmiotu podobnie niebezpiecznego do broni palnej i noa cho wystpuje w kilku przepisach, to jednak obecnie nie jest zdefiniowane w kodeksie karnym. Wskazanie takich przedmiotw zostao pozostawione sdom. Celem artykuu jest prba oceny skutkw uycia opaty i szpadla przy ataku na czowieka w kontekcie uznania tych przedmiotw za podobnie niebezpieczne do broni palnej i noa. Materia badawczy stanowi wyroki wydziaw karnych sdw powszechnych. Jako wniosek wyania si stanowisko, e zakres medycznych i prawno-karnych skutkw uycia opaty i szpadla przeciwko czowiekowi jest bardzo szeroki. Przedmioty te powinny by traktowane jako podobnie niebezpieczne do broni palnej i noa.opata, szpadel, obraenia ciaa, kodeks karny
Szacowanie ryzyka w tajnych operacjach Cz 2
Authors: Horosiewicz Krzysztof
Published: June 2023

Tajne operacje policyjne s wykorzystywane do najpowaniejszych przestpstw, gdy wyczerpay si moliwoci innych metod operacyjnych. Specyfika tej niestandardowej taktyki dziaa policyjnych wie si z wieloma zagroeniami dla uczestniczcych w niej policjantw pod przykryciem. Niniejsze opracowanie ma na celu zbadanie zagroe towarzyszcych tajnym operacjom prowadzonym w Polsce oraz okrelenie, w jakim stopniu dowiadczenie wpywa na ocen ryzyka i zachowania policjantw uczestniczcych w takich operacjach. Badania empiryczne przeprowadzono metod sondau diagnostycznego. Wyniki bada nie potwierdzaj jednoznacznie zwizku midzy dowiadczeniem policjantw a ocen ryzyka. Pozwalaj jednak na wnioskowanie o ich zachowaniu podczas tajnych operacji.Tajne operacje policyjne s wykorzystywane do najpowaniejszych przestpstw, gdy wyczerpay si moliwoci innych metod operacyjnych. Specyfika tej niestandardowej taktyki dziaa policyjnych wie si z wieloma zagroeniami dla uczestniczcych w niej policjantw pod przykryciem. Niniejsze opracowanie ma na celu zbadanie zagroe towarzyszcych tajnym operacjom prowadzonym w Polsce oraz okrelenie, w jakim stopniu dowiadczenie wpywa na ocen ryzyka i zachowania policjantw uczestniczcych w takich operacjach. Badania empiryczne przeprowadzono metod sondau diagnostycznego. Wyniki bada nie potwierdzaj jednoznacznie zwizku midzy dowiadczeniem policjantw a ocen ryzyka. Pozwalaj jednak na wnioskowanie o ich zachowaniu podczas tajnych operacji.
Determinación de variación estadística entre uso de tiras reactivas de orina humano y veterinario en caninos
Authors: Bonilla-Espinel Sebastián Elías , Rubio-Arias Pablo Giovanny
Published: June 2023

La producción de orina es esencial para el sistema urinario. Los riñones mantienen la homeostasis y eliminan desechos a través de la orina. El uroanálisis analiza la orina y proporciona información valiosa sobre la salud y el sistema urinario. En veterinaria, el uroanálisis es importante para el diagnóstico y tratamiento. Este estudio comparó tiras reactivas de orina humanas y veterinarias. Se analizaron muestras de perros sanos y enfermos. Se evaluaron varios analitos, como leucocitos, cetonas, nitritos, urobilinógeno, bilirrubina, glucosa, proteína, densidad de orina, pH, sangre, ácido ascórbico, microalbúmina, creatinina y el cociente proteína/creatinina. Se encontraron diferencias en la sensibilidad de las tiras reactivas para detectar analitos específicos. Por ejemplo, las tiras veterinarias fueron más sensibles para leucocitos y cetonas, mientras que las humanas lo fueron para urobilinógeno y glucosa. Sin embargo, se necesitan más investigaciones debido a datos atípicos en algunos casos. Este estudio proporciona información para interpretar y manejar los resultados del uroanálisis en veterinaria. Se recomienda utilizar las tiras reactivas adecuadas y considerar las diferencias en la sensibilidad de los analitos al interpretar los resultados. Estos hallazgos mejoran la práctica clínica y la atención veterinaria en problemas urinarios.
El uso de la prisión preventiva en Perú
Authors: Caira-Yucra Ruth Mery , Vilca-Vilca Lenin Elvis , Vilca-Vilca Miguel Ángel , Caira-Yucra Rolando
Published: June 2023

Este artículo examina el uso de la prisión preventiva en el sistema penal peruano mediante una revisión bibliográfica y comparativa. A pesar de su naturaleza excepcional, la prisión preventiva se utiliza con frecuencia en Perú, planteando serias preocupaciones sobre los derechos humanos y las condiciones de detención. A través de un análisis comparativo con otras jurisdicciones, se exploran diferentes enfoques y justificaciones teóricas para la prisión preventiva. En particular, el estudio destaca la importancia de clarificar y fortalecer los criterios para el uso de la prisión preventiva, promover la transparencia y la rendición de cuentas, y fomentar la participación pública y democrática en la toma de decisiones. A partir de propuestas de académicos y políticos, se sugieren diversas reformas, incluyendo cambios en la legislación, mejor formación para los operadores judiciales, y el fomento de medidas alternativas a la prisión preventiva. El análisis concluye que, si bien la prisión preventiva es una herramienta necesaria en el sistema penal, su uso en el Perú plantea serios desafíos y necesita reformas. Las lecciones aprendidas de otras jurisdicciones, junto con las propuestas de académicos y políticos, pueden proporcionar un camino valioso hacia una prisión preventiva más justa, eficaz y respetuosa con los derechos humanos en el Perú.
A AUTOMATIZAÇÃO CONTÁBIL E A EXPANSÃO DA CONTABILIDADE DIGITAL RELACIONADA À APLICAÇÃO DOS NOVOS PROCESSOS E A RELEVÂNCIA NO MERCADO: ESTUDO SOBRE PERCEPÇÃO E EXECUÇÃO DE PROCESSOS EM UM ESCRITÓRIO CONTÁBIL NA CIDADE DE LAGOA DOURADA – MG
Authors: Resende Arnon Andrade Ferreira , Martins Pablo Luiz , Bernado Denise Carneiro dos Reis
Published: June 2023

Através das constantes mudanças no mercado profissional, todas as áreas de atuação têm sofrido impactos e isso inclui a contabilidade. Tudo isso tem feito com que as organizações tenham que se modernizar, se capacitando a esse novo formato, que é mais tecnológico e automatizado. Assim sendo, o presente estudo tem como objetivo evidenciar os benefícios trazidos pelos avanços da contabilidade através da automatização de processos, que tem como foco o aumento do uso de sistemas e da tecnologia da informação. Como todas essas mudanças vem acontecendo rapidamente, exige dos profissionais mais habilidades e uma adaptação contínua, o que quer dizer que mesmo com as melhores ferramentas disponíveis no mercado, há a necessidade de o contador deixar de ocupar as funções que ocupava anteriormente e saber lidar com o novo papel que precisa assumir, dando mais apoio às empresas de maneira consultiva e analítica, e ter conhecimento para conduzir os processos com segurança dos dados, pois se a tecnologia automatizou a maior parte dos processos e é benéfica, em contrapartida a mesma também possui seus riscos. Sendo assim, podemos entender que o correto preparo e a atualização constante são formas dos profissionais que trabalham na área contábil se capacitarem para melhor atenderem as demandas do mercado.
Spring Meeting of the Young Researchers of SID, SIIA, SIMI, SIPREC, SISA
Authors: Pavanello Chiara , Bianconi Vanessa , Da Dalt Lorenzo , Gallo Giovanna , Mancusi Costantino , Ciccarelli Michele , Maloberti Alessandro , Spannella Francesco , Fimiani Fabio , D’Ardes Damiano , Lombardi Rosa , Talerico Giovanni , Cavallo Massimiliano
Published: June 2023

The VIII Spring Meeting of Young Researchers of the Italian Society of Diabetology (SID), the Italian Society of Arterial Hypertension (SIIA), the Italian Society of Internal Medicine (SIMI), the Italian Society of Cardiovascular Prevention (SIPREC) and the Italian Society for the Study of Atherosclerosis (SISA) “Basic and clinical research: Until grant let us apart” was held in Rimini on April 16-18, 2023. As is customary, the Congress was organized by the young members of the aforementioned scientific societies operating in the cardiometabolic field. The Congress featured five sessions dedicated to the discussion of the recent evidence from both basic and clinical researchers in cardiometabolic treatment and prevention. Many young researchers had the opportunity to present their scientific works in dedicated oral and poster sessions. In this report, we provided a summary of the main issues discussed during the Meeting lectures.
Statin-Associated Muscle Symptoms: Clinical Index in a hypertensive population candidated to lipid-lowering therapy but not taking statins
Authors: Sarzani Riccardo , Giulietti Federico , Allevi Massimiliano , Sarnari Silvia , Alessandroni Romina , Di Pentima Chiara , Spannella Francesco
Published: June 2023

Aim: Statin-associated muscle symptoms (SAMS) are claimed to be frequent in clinical practice. The SAMS-clinical index (SAMS-CI) assesses the likelihood that muscle symptoms are related to statin use. We evaluated the prevalence and characteristics of muscle symptoms in hypertensive patients eligible for statin therapy according to their individual cardiovascular risk. Methods: Observational study on 390 consecutive outpatients referred to our Centre. All patients were asked the following question: “Have you ever taken a drug/nutraceutical that you think gave you muscle symptoms?”. Patients who answered “yes” were evaluated with SAMS-CI. Results: Mean age: 60.5±13.5 years. Male prevalence: 53.8%. Patients who have ever taken a statin (“statin+” group): 250. Patients who have never taken a statin but have taken at least one other drug (“statin-” group): 140. Prevalence of muscle symptoms did not differ between the groups (p=0.217). Age and number of drugs taken were significantly associated with muscle symptoms at multivariate analysis. A not clinically significant higher SAMS-CI score emerged in the “statin+” group (p=0.004). Localization and pattern of muscle symptoms did not differ between the groups (p=0.170). Timing of muscle symptoms onset after starting the drug (p=0.036) and timing of symptom improvement after withdrawal (p=0.002) were associated with statin therapy. Conclusions: Prevalence of patient-reported muscle symptoms was not associated with statin therapy in our real life clinical study, confirming the growing evidence that subjective muscle-related symptoms are often misattributed to statins, while they may more likely be related to the nocebo/drucebo effect or other common undiagnosed conditions.
Exosomal miRNAs targeting NLRP3 inflammasome platform are associated with radiologic sequelae in survivors of COVID-19-associated acute respiratory distress syndrome
Authors: Curcio Rosa , Poli Giulia , Fabi Consuelo , Sugoni Chiara , Pasticci Maria Bruna , Ferranti Roberto , Rossi Monica , Folletti Ilenia , Sanesi Leandro , Santoni Edoardo , Dominioni Irene , Cavallo Massimiliano , Morgana Giovanni , Mordeglia Lorenzo , Luca Giovanni , Pucci Giacomo , Brancorsini Stefano , Vaudo Gaetano
Published: June 2023

Background: There is limited understanding of the pathophysiology of post-acute pulmonary sequelae in COVID-19-associated acute respiratory distress syndrome (ARDS). We aimed at investigating the association of circulating microRNAs (miRNAs) involved in post-transcriptional regulation of NLRP3-inflammasome pathways and lung radiological features among COVID-19- associated ARDS survivors. Methods: We evaluated COVID-19-associated ARDS survivors at 4±2 months from clinical recovery. Patients were selected based on imaging pattern evolution according to chest high-resolution computerized tomography (HRCT) findings into “fully recovered” (FR), “pulmonary opacities” (PO) and “fibrosis-like lesions” (FL) according to radiological appearance. Plasma miRNA profiling was performed using real time quantitative polymerase chain reaction (RT-qPCR). The exosomal expression of NLRP3 inflammasome related miRNAs (miR-17-5p, miR-223-3p, miR-146a-5p) was evaluated. Results: 31 patients (33% men, mean age 60±6 years, mean BMI 31.1±6.6 Kg/m2) were selected for the present study. No statistically significant differences between FR, PO and FL patterns were observed according to clinical features. NLRP3-inflammasome-related miRNAs such as miR-17-5p, miR-223-3p and miR-146a-5p were significantly up-regulated in patients with PO when compared to patients with FL. miR-146a-5p was also up-regulated in patients with FL than in FR. Conclusions: In patients with long-term pulmonary radiological sequelae following COVID71 19- associated ARDS, a down-regulation of miRNAs inhibiting NLRP3 (miR-17-5p, miR-146a72 3p and miR-223-3p) correlated to fibrosis development in patients showing persistent hyper-reactivity to inflammatory stimulation. NLRP3-Inflammasome-related miRNAs could be a possible therapeutic target to prevent the fibrotic evolution of COVID-19-associated ARDS.
Change over time of lipid profile relates to steroid treatment but not to an inflammatory state in Granulomatosis with poliangioitis polyangiitis (GPA)
Authors: Marozzi Marialuisa S. , Panebianco Teresa , Vacca Antonio , Dipaola Valeria , Noviello Silvia , Solimando Antonio Giovanni , Cicco Sebastiano
Published: June 2023

Aim: Granulomatosis with polyangiitis (GPA) is a small vessel vasculitis. Inflammation of the vessel wall may induce multiple vascular damages. Atherosclerosis is accelerated during vasa inflammation. Metabolic profile and cardiovascular risk are far to be determined in these patients. Thus, Cardiovascular atherosclerotic disease (ASCVD) may represent a risk for patients' outcomes. The purpose is to evaluate ASCVD risk in GPA over time during disease follow-up. Methods: We retrospectively evaluated 37 patients (22 Females, aged 51.45±17.15) who received a diagnosis of GPA (T0). Patients were evaluated at 1 (T1) and 2 (T2) year follow-up. All patients were treated with high steroid dose followed by a one-year tapering, associated to another immunosuppressant. Lipid profile included total cholesterol, HDL, LDL and Triacylglycerol. To evaluate inflammatory activity, we evaluate erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) and neutrophil to lymphocyte ratio (NLR) at the same time points. ANOVA for repeated values was used to evaluate the trend over time and Tukey's multiple comparisons test was a second step evaluation. Results: At T1 there was an increase in total cholesterol compared to baseline (T1vsT0, p<0.05) and T2 (T1vs T2, p<0.05). Similarly, LDL (T1vsT0, p<0.05) presents the same trend, while Triacylglycerol increased in T1 compared to baseline (T1vsT0, p<0.05), but no difference there was in T2 compared to T1 or T0. No difference was found in HDL between the different time points. CRP was no different, despite a reduction being noticed. On the contrary, we found a reduction at T2 but not in T1 in ESR (T1vsT0, p<0.05) and NLR (T1vsT0, p<0.05). Conclusion: Our data suggest that a change in lipid profile may not relate to better control of inflammation. On the contrary, the increase in the first year of follow-up should be a consequence of steroid treatment needed to spread disease control. These data may be helpful in the evaluation of both cardiovascular disease and lipid metabolism due to the connection between the two parameters with vessel inflammation. Further studies are needed to better evaluate the cardiovascular effect of vasculitis and consequent treatment.
Dapagliflozin counteracts the pro-apoptotic effects of the secretome of visceral adipose cells from obese subjects in human cardiac progenitor cells via the SGLT2 co-transporter
Authors: Palma Giuseppe , Caccioppoli Cristina , D’Oria Rossella , Genchi Valentina Annamaria , Calderoni Isabella , Braun Antonio , Santarpino Giuseppe , Milano Aldo Domenico , Cignarelli Angelo , Natalicchio Annalisa , Laviola Luigi , Pezzolla Angela , Giorgino Francesco , Perrini Sebastio
Published: June 2023

Aim: Dapagliflozin (DAPA), an SGLT2 inhibitor, has been shown to counteract heart failure outcomes in subjects with obesity and diabetes. We investigated the protective mechanisms of DAPA in human cardiac progenitor cells (hCPC) exposed to the conditioned medium (CM) from abdominal visceral (AV) and epicardial (E) adipose stem cells (ASC) and from AV mature adipocytes from obese subjects. Methods: ASC and mature adipocytes were isolated from AV adipose tissue biopsies of 27 obese (Ob) and 19 non-Ob subjects (n-Ob), and from E adipose tissue biopsies of 9 Ob and 10 non-Ob subjects, respectively. hCPC were isolated from right auricle biopsies of 10 healthy non-Ob donors. Results: Exposure of hCPC to the CM of adipose cells from Ob, but not from non-Ob subjects, induced apoptosis, c-Jun phosphorylation, and impairment of actin filaments, while these effects were not observed when hCPC were pretreated with DAPA. The CM of adipose cells from Ob compared to n-Ob subjects displayed a different pattern of cytokines. The levels of pro-inflammatory cytokines RANTES and MIP1β were increased in the CM from AV-ASC with higher BMI (p<0.05), while the levels of the cardioprotective factor GCSF in the CM of E-ASC were inversely correlated with BMI (p<0.05). SGLT2 was found to be expressed as both mRNA and protein in hCPC, and silencing of SGLT2 with a specific siRNA abrogated the capacity of DAPA to counteract the pro-apoptotic effects of the CM. Conclusions: In human obesity, the CM of both AV- and E-ASC and mature adipocytes is characterized by pro-inflammatory cytokines that induce stress kinase activation and apoptosis in hCPC. DAPA prevents the hCPC damage induced by the CM through an SGLT2-dependent mechanism.
Thrombocytopenia and Kidney disease, two possible hallmark of FCS phenotype: preliminary evidence from a cohort study
Authors: Tramontano Daniele , Bini Simone , Di Costanzo Alessia , Minicocci Ilenia , Covino Stella , Arca Marcello , D’Erasmo Laura
Published: June 2023

Background and Aim: Familial Chylomicronemia Syndrome (FCS) is a rare monogenic autosomal recessive disorder of lipid metabolism determining severe hypertriglyceridemia (HTG). As the use of Volanesorsen, a novel FCS treating drug, has been associated with thrombocytopenia, the relationship between FCS and low platelets counts should be firmly established. It has been reported also kidney complication in FCS, but the data are sparse. To this aim, we have retrospectively evaluated the spontaneous variation of platelet counts and Kidney impairment in a cohort of patients with FCS. Methods: Single-center retrospective cohort study on 20 FCS patients included in the LIPIGEN. Medical charts have been revised to collect retrospectively information on kidney function in a cohort of patients with FCS. Results: Across the study population, the median PLT count was 187,225 platelet/mcL. The median on treatment TG levels in the whole cohort was 1309 mg/dl. During follow-up, 8 (44.4%) patients experienced at least one episode of mild and 1 (5%) of moderate thrombocytopenia. None had severe thrombocytopenia. Mean triglycerides do not significantly predict mean platelet values. However, when considering a multivariate model including mean triglycerides, sex, the presence of hepatic steatosis and age we found that male sex and the presence of ultrasound estimated hepatic steatosis were associated with significantly lower platelet (respectively β-0,473, P=0,044 and β-0,469, P=0,048). Age was of borderline statistical significance (β-0,388, P=0,087). Across the study population, the median GFR values was 99.5 ml/min. Median eGFR was significantly associated with history of hypertension (β-0,508, P=0,031). Overall, proteinuria occurred in 5 (25%) patients, and it did not associate with hypertension, diabetes, age, sex nor triglyceride levels. Four (20.0%) patients meet the criteria of hyperfiltration whereas 3 (15.0%) were exhibiting an eGFR below 90 ml/min. Among hyperfiltrating, two had also proteinuria in at least one occasion during life. One patient with eGFR below 90 ml/min and proteinuria had a biopsy-proven diagnosis of glomerulonephritis. Overall, the impairment in kidney function was independent from age, diabetes, hypertension, median TGs, AP, sex. Conclusions: The present analysis confirmed that thrombocytopenia and kidney impairment might be a clinical characteristics of FCS phenotype. Further studies in larger cohort are needed to better clarify if kidney disease and thrombocytopenia might be a hallmark of FCS in broader population and understand the potential patho-physiological mechanism.
Aspectos Genéticos comuns entre o Transtorno do Espectro Autista e Transtorno do Déficit de Atenção e Hiperatividade
Authors: Medeiros Matheus Mastrianni Lima , Martins Jade Souza , Dantas João Marcos da Silva , Vieira Helder Elísio Evangelista , Martins Albert Eduardo Silva
Published: June 2023

Objetivo: A análise dos estudos selecionados, em relação à etiologia genética da associação do transtorno do espectro autista e transtorno do deficit de atenção e hiperatividade foi realizada de forma descritiva, possibilitando observar, descrever e classificar os dados, com o objetivo de unir o conhecimento sobre o tema. Metodologia: Foi feita uma dupla revisão da literatura nas bases de dados BVS e PubMed. Para a pesquisa na BVS foram utilizados os seguintes descritores e operadores booleanos: (Transtorno Autístico) OR (Transtorno do Espectro Autista) AND (Transtorno do Déficit de Atenção com Hiperatividade) AND (Estudos de Associação Genética) OR (Genética) OR (Hereditariedade). Já para a busca no PubMed foram utilizados: ("Autism Spectrum Disorder") AND ("Attention Deficit Disorder with Hyperactivity") AND ("Genetic Association Studies") OR Genetics OR Heredity). Resultados: Foram recuperados 75 artigos, sendo 54 da BVS e 21 do PubMed. Destes, 57 foram descartados a partir da leitura dos títulos e resumos, restando 18, dos quais, após a leitura completa, 9 foram incluídos. Discussão: As mutações gênicas ‘de novo’ são comprovadamente contribuintes para o transtorno do espectro autista e algumas evidências as colocam como possíveis determinantes para o transtorno do déficit de atenção e hiperatividade. Os genes RFX3, RFX4 e RFX7 encontrados em células do córtex cerebral de fetos e em adultos, contribuem para a comunicação de regiões importantes à cognição e comportamento social. Conclusão: De acordo com os dados evidenciados, é possível observar a correlação genética das etiologias do transtorno do espectro autista e transtorno do déficit de atenção e hiperatividade.
Aplicações terapêuticas do Hypericum perforatum (erva-de-são-joão) no tratamento da ansiedade e depressão
Authors: Chagas Alany Lima Soares , Moura Heloise Gabriella Queiroz , Sá Klyvia Renaly Brayner de , Nascimento Laila Caroline Duarte , Guedes Larissa Cândida Pereira , Moura Priscyla Gonçalves Pinheiro , Cruz Tharcia Kiara da
Published: June 2023

O Hypericum Perforatum, também conhecido como erva de São João é uma planta medicinal popular recomendada pelos praticantes da medicina tradicional chinesa e amplamente prescrita para a depressão em muitos países europeus. No entanto, existem dados conflitantes sobre seus benefícios e riscos. O objetivo deste estudo foi avaliar os benefícios e riscos dos fitoterápicos contendo Hypericum perforatum. no tratamento da ansiedade e depressão. Realizou-se uma revisão integrativa a partir de artigos publicados em nas bases científicas Literatura Latino-americana e do Caribe em Saúde (LILACS), Scientific Electronic Library Online (SciELO) e Publisher Medline (PubMed) entre os anos de 2017 a 2022 nos idiomas português, inglês e espanhol. Evidências de ensaios clínicos randomizados confirmaram a eficácia dos extratos de Hypericum Perforatu. em relação ao placebo no tratamento da depressão leve a moderadamente grave. Outros estudos randomizados controlados forneceram algumas evidências de que os extratos da planta são tão eficazes quanto alguns antidepressivos convencionais na ansiedade e depressão leve a moderada. Conclui-se que há a necessidade de mais estudos para avaliar a eficácia dos extratos de Hypericum Perforatum, principalmente no que se refere aos eventos adversos, possíveis riscos e interações com outros medicamentos.
Síndrome de Heyde
Authors: Lages Dolly Brandão , Pacífico Fernando Augusto , Paixão Maria Luiza Curi , Oliveira Flavio Roberto  Azevedo de , Couto Mário Cruz , Farias Michelle Alves de , Paixão Eduardo Lins
Published: June 2023

A estenose aórtica valvar (EAo) calcificada é uma entidade clínica frequente, particularmente em idosos. Muitos desses pacientes apresentam quadro clínico associado de anemia. Entre as possibilidades para essa alteração hematológica encontra-se a Síndrome de Heyde, que é uma anemia associada a angiodisplasia intestinal e perda de multímeros de alto peso molecular (MAPM) do fator de von Willebrand (FvW). A resolução de síndrome ocorre com a correção da estenosa aórtica. A Síndrome de Heyde deve fazer parte do diagnóstico diferencial entre pacientes com anemia e portadores de estenose valvar aórtica severa.
Geochemical Characteristics of Mafic Dykes from Wairagarh Area, Western Bastar Craton, Central India
Authors:   Department of Geology, RTM Nagpur University, Nagpur-440001(MS), India, Deshmukh S.B. , Pophare A.M. , Murkute Y.A. , Wadpalliwar G.G.
Published: June 2023

The NW-SE trending mafic dykes intrude the Amgaon gneisses and Dongargarh granite in Wairagarh area of the Western Bastar Craton (WBC). These dykes consist of mainly the clinopyroxene, plagioclase feldspar and minor amphiboles and titano-magnetite. These are metamorphosed to green schist facies. The mafic dykes show tholeiitic trend on multivariate geochemical plots and moderate range of variation in SiO2 (50.15 to 52.84 wt.%), MgO (5.13 to 7.64 wt.%), Fe O (12.97 to 15.08 wt.%), Al O (12.74 to 14.48 wt.%) and the Mg# value ranges from 37.74 to 51.21. Strong positive correlation of Sr, Th, Hf, U, Ga, Ta, Pb, Cs, Rb and HREEs negate the effect of post magmatic alteration. Negative Nb, Ta and Ti with positive Zr and Hf anomalies suggest the effect of assimilation and crustal contamination, which is also supported by Ce/Nb (0.23-0.33) equivalent to the crustal value. Negative ΔNb value suggests depleted mantle source for the mafic dykes of the WBC. Restricted range of (Gd/Yb)N (1.05-1.67), (Dy/Yb)N (0.94-1.25) and (Sm/Yb)N (1.22-2.26) advocate that these mafic dykes were derived from spinel lherzolite source. About 5-15% degrees of partial melting of depleted mantle source is envisaged for the generation of the mafic dykes. The field and geochemical evidences suggest that the mafic dykes of Wairagarh area, WBC were emplaced within continental rift environment. Keywords: Mafic dykes, Geochemistry, Wairagarh, Bastar Craton, Central India
Relationship of Modern Diatoms with Lake Acidification and Water Quality in Nsonji Lake of Nagaland, North-East India
Authors:   Department of Geology, University of Madras, Chennai-600025(TN), India, Kere Zayieno , Humane Samaya S. , Hussain Shaik Mohammad
Published: June 2023

Understanding the relationship of diatoms and water quality is of paramount importance to link it to Holocene Climate Change. Since diatoms are extremely sensitive to environmental changes, they are the obvious choice to study diatom inferred water quality and climate changes. Therefore, sediment samples along with water samples were collected during pre monsoon seasons from the Nsonji Lake of the Nagaland, India to establish the relationship between the diatom and water quality. The Nsonji Lake has circum-neutral pH (around 7) indicating gradual degradation of organic matter leading to acidification of the lake. The surface sediments of the Nsonji Lake revealed the dominance of Discostella stelligera, Achnanthidium sp., Navicula cryptocephala, Navicula radiosa and Nitzschia palea. These diatom species could be used to unravel the acidification history of lake caused by natural and anthropogenic activities. Understanding the past climate dynamics need modern analogue in order to evaluate the important processes relative to Earth's history and built future scenario. Keywords: Diatoms, Water Quality, Acidification, pH, Organic Matter, Nsonji Lake, Nagaland
Diseño de un plan administrativo financiero para la captación de clientes en entornos turísticos: caso NH Hoteles en la península Ibérica.
Authors: Izquierdo-Obando Joseph Eli , Intriago-Mera Rafael Aníbal , Alencastro-Guerrero Paúl , Alencastro-Guerrero Junior , Hurtado-Hinestroza Rider Alexander , Sampietro-Saquicela José Luis
Published: June 2023

El siguiente trabajo se basa en la propuesta de un plan de marketing para la cadena NH Hotels. El estudio se centrará en aumentar el número de clientes/huéspedes en la cadena hotelera de NH dentro de España. En primera instancia se realizará un análisis de la situación actual de la empresa, de sus determinantes internos y externos y de su macroentorno que permita comprender el mercado y desenvolvimiento de la empresa con el fin de definir una estrategia de marketing que aumente la cantidad de clientes en esta cadena.
التعامل الأمريكي المزدوج مع التدخلات العسكرية الروسية في سوريا وأوكرانيا
Authors: KALAYCI Halid , KOUR Yser
Published: June 2023

ملخص البحث: عند تحديد طبيعة التفاعل الأمريكي مع التدخل العسكري الروسي في كل من سوريا وأوكرانيا، حاولنا تحليل ثلاثة أبعاد (سياسية، اقتصادية، عسكرية)، وكذلك تحليل الدوافع والأسباب المختلفة لكلا الحالتين السورية والأوكرانية من جانب آخر. كانت أبرز أداوت التفاعل الأمريكي في أوكرانيا سلسلة ضخمة وشاملة من العقوبات الاقتصادية والتي ارتقت في نظر بعض الباحثين إلى مرحلة "الحرب الاقتصادية" مع إمداد الجيش الأوكراني بالأسلحة المتطورة والمعلومات الاستخباراتية والمساعدات الإنسانية والمالية المكثفة. في حين اقتصرت أدوات التفاعل الأمريكي في دعم بعض قوات المعارضة السورية على أنواع محددة من الأسلحة "غير الفتّاكة"، والعقوبات الاقتصادية على النظام السوري والتي كان أهمها "قانون قيصر" . وشكلت الحالة الأوكرانية عامل ضغط كبير على الشركاء الأوربيين لواشنطن، في حين أنّ الحالة السورية لم تصل لحجم ذلك الضغط على أي من شركاء واشنطن في المنطقة، وبالتالي اتصف التفاعل الأمريكي مع التدخل العسكري الروسي في أوكرانيا بالجديّة تبعاً لما له من مقومات الحيويّة والمصلحة، على عكس الحالة السورية والتي باتت أشبه بقضيّة مجمّدة في نفق مظلم تنتظر متغيرات محورية تدفع الإدارة الأمريكية على بذل مزيد من الاهتمام لإخراجها من ذلك النفق.
Development Strategies and the Impact of Marine Tourism on the Socio-Economic Conditions of Communities Around Jepara Regency Based on Ecotourism
Authors: Dena Ayu Aviantih  , Sucihatiningsih dian wisika prajanti  , Shanty Oktavilia
Published: June 2023

Tourism development has a direct effect on the community, the existence of tourism should have an impact on the conditions or conditions in the environment and around the tourism. In this case, marine tourism in Jepara Regency continues to be developed. The purpose of this study is to determine and analyze the impact of marine ecotourism development in Jepara Regency on the economic and social aspects of the community. The research methods employed include descriptive statistical analysis and the Analytical Hierarchy Process (AHP) method. The study's findings indicate that Jepara Regency's marine ecotourism has a significant impact on the economic and social aspects of the community. This is evident through increased income, the creation of new business opportunities, and an improved standard of living for the community. The social dynamics of the community are also affected, including employment status, community cooperation, and the establishment of new norms and values. Based on the AHP analysis, the recommended policies for managers and decision-makers in the development of marine ecotourism in Jepara Regency include efforts to enhance infrastructure that facilitates access to marine tourist destinations, the implementation of fiscal incentives and support for micro small medium enterprise (MSMEs) in the destination area, and achieving growth in visitor numbers while maintaining environmental quality by imposing penalties on tourists who harm the environment.
Manejo Integral de Fracturas en Ortopedia
Authors: Jiménez Jiménez Miguel Sebastian , Rodríguez Montalván Ángel Luis , Lopez Garcia Angela , Parra Castilla Keyner Zoil , Llanos García Joffre David , Astudillo Abad Carlos Andrés , Ponce Romerate Juan Carlos
Published: June 2023

"Manejo Integral de Fracturas en Ortopedia" se erige como un recurso imprescindible para cualquier ortopedista, médico de emergencias o estudiante de medicina. Este libro ofrece un enfoque holístico y actualizado de la evaluación, diagnóstico y tratamiento de una variedad de fracturas óseas, haciendo hincapié en el manejo interdisciplinario y el cuidado centrado en el paciente. Los autores abarcan una amplia gama de fracturas, desde las más comunes hasta las más complejas y difíciles de tratar. Cada capítulo está dedicado a un tipo específico de fractura, discutiendo la anatomía relevante, la fisiopatología de la lesión, el enfoque diagnóstico, y las últimas técnicas y enfoques de tratamiento. Las discusiones son claras y detalladas, respaldadas por ilustraciones de alta calidad y radiografías que enriquecen la comprensión de la patología.
Actualización en Traumatología Vol. 1
Authors: Muñoz Ortega Carlos Eduardo , Carreño Barrera Victor Daniel , Pacheco Aymacaña Pablo Esteban , Villacrés Sánchez Ana Lucia , Tixi Torres Joivin Alberto
Published: June 2023

"Actualización en Traumatología Vol. 1" es un recurso esencial y de gran valor que proporciona una revisión exhaustiva y actualizada del campo de la traumatología. Destinado a profesionales de la salud que trabajan en el área de traumatología y ortopedia, así como a estudiantes de medicina, este libro sirve como una guía práctica y teórica para el diagnóstico y tratamiento de una amplia variedad de lesiones traumáticas.
Pediatría General Tomo 7
Authors: Buitrón Ruiz María de los Ángeles , Durán Henríquez Olga Valeria , Escobar Andrade Paola Mireya , Cabezas Euvin Daniel , Riofrío Malla Alexandra del Cisne , Palacios Serrano Susana Patricia , Bermúdez Valladares María del Carmen
Published: June 2023

"Pediatría General Tomo 7" continúa la serie de referencia en pediatría, proporcionando una visión actualizada y completa del cuidado de los niños y adolescentes. Este tomo, al igual que los anteriores, está dirigido a pediatras, médicos de familia, residentes en formación y estudiantes de medicina que buscan expandir su conocimiento en el campo de la pediatría.
Tratado de Cirugía General en Atención Primaria en Salud Tomo 3
Authors: Moreno Ponce Luis Antonio , Erazo Salame Martin Andre , Dominguez Berrazueta Melissa Sofía , Díaz Yaguachi Fabricio Miguel , Barahona Coloma Gabriela Estefania , Gualancañay Zurita Yosselin Yolanda , Novillo Tacuri María José
Published: June 2023

El "Tratado de Cirugía General en Atención Primaria en Salud Tomo 3" sigue a sus predecesores como una guía definitiva y exhaustiva para los profesionales de la salud que practican en el entorno de la atención primaria. Este libro es particularmente útil para médicos de familia, internistas, cirujanos generales, residentes y estudiantes de medicina.
Manual de Endocrinología y Metabolismo Vol. 1
Authors: Uvidia Cepeda Galo Marcelo , Jami Suárez Génesis Michelle , Castillo Zambrano Stephanie Denisse , Barba Carrillo Génesis Leonor , Gamboa Zamora Angie Nicole
Published: June 2023

"Manual de Endocrinología y Metabolismo Vol. 1" es un recurso integral dirigido a endocrinólogos, médicos generales, residentes y estudiantes de medicina que buscan profundizar su conocimiento en los campos de la endocrinología y el metabolismo. Esta obra presenta una visión actualizada y completa de los trastornos endocrinos y metabólicos más comunes y su manejo.
Comparative Evaluation Of The Shear Bond Strength Of Two Different Orthodontic Bonding Agents On Artificial Crown Surfaces: An Invitro Study
Authors: Polineti Priyanka , Manda Anoosha , Kandikatla Pradeep , C.V Padma priya , Datla Praveen Kumar Varma , Tivanani Venkata Durga Mahendra , Velagala Sai Keerthi
Published: June 2023

INTRODUCTION: Bonding of buccal tubes to the tooth is an essential procedure in orthodontic treatment. With the increase in the number of adult patients seeking fixed orthodontic treatment, there is a need to find a more reliable procedure to bond the artificial crown surface. Successful orthodontic treatment requires sufficiently high and durable bond between buccal tubes and ceramic/zirconia surfaces. There is a need for a bonding agent which can provide maximum bond strength to all surfaces. This study aimed to assess and compare the shear bond strength and adhesive remnants of orthodontic buccal tubes to natural teeth, ceramic crowns and zirconia crowns using two different bonding systems.
METHODS: In this in vitro study, 60 extracted human molar teeth were randomly assigned to three groups (n=20) and then divided into two subgroups(n=10). Bonding of buccal tubes to enamel, ceramic and zirconia surfaces was done using Assure plus universal bonding resin and Enhance LC. The shear bond strength of buccal tubes to the enamel, ceramic and zirconia surfaces were determined by universal testing machine. The SBSs and ARI scores were statistically analysed with and Kruskal Wallis test.
RESULTS: The mean shear bond strength of buccal tubes to enamel, ceramic and zirconia surfaces bonded with Assure plus and Enhance LC was highest for enamel followed by zirconia surfaces respectively. Non-parametric Kruskal-Walli’s test found significant differences regarding the shear bond strength and adhesive remnant index (ARI).
CONCLUSION: Bonding of buccal tubes to enamel, zirconia, and ceramic surfaces with Assure universal bonding resin and Enhance LC provided adequate bond strength. Thus, it may be used for bonding of orthodontic buccal tubes to the artificial crown surfaces in the clinical setting.
Global Currency Wars: Implications for Emerging Economies
Authors: Angelov Ivaylo
Published: June 2023

This paper examines the implications of global currency wars for emerging economies. Currency wars, defined as competitive devaluations of currencies by countries to boost their exports and economic growth, have become increasingly common in recent years. The impacts of currency wars on emerging economies are significant and multifaceted, including exchange rate volatility, inflation, trade imbalances, and capital flows. The paper analyzes case studies of Brazil, China, and India to illustrate the different responses of emerging economies to currency wars. The paper then discusses policy options for emerging economies, including exchange rate management, capital controls, monetary policy coordination, and regional cooperation. The paper concludes with a discussion of the future outlook for currency wars and their implications for emerging economies and offers policy recommendations for emerging economies to navigate this complex landscape.
Impulsividad y dependencia emocional en estudiantes universitarios
Authors: Alarcón Zapata Giannella Anahí , Cueva Rubio María Augusta
Published: June 2023

El objetivo del estudio fue determinar la relación entre impulsividad y dependencia emocional en estudiantes universitarios a partir de un enfoque cuantitativo, de alcance correlacional, con diseño no experimental transversal, en una muestra conformada por 150 estudiantes universitarios (63% hombres y 37% mujeres). Para la evaluación se utilizó la Escala de Impulsividad de Barratt (BIS-11) y el Cuestionario de Dependencia Emocional de Lemos y Londoño (CDE). En cuanto, a los resultados se evidencia que la mayor parte de la población presenta un nivel de impulsividad alta y en dependencia emocional predomina el nivel leve, además, no se encontró alguna diferencia significativa entre mujeres y hombres en cuanto a la variable impulsividad. Finalmente, se concluye que existe una correlación positiva leve entre impulsividad y dependencia emocional.
Ansiedad y riesgo suicida en estudiantes universitarios
Authors: Carrera Arias Diana Micaela , Vargas Espín Alba del Pilar
Published: June 2023

La ansiedad es un trastorno de salud mental que provoca en la persona un sinnúmero de síntomas, entre los que podemos mencionar: miedo intenso, preocupación, dificultad para concentrarse, sensación de nerviosismo, temblores, entre otros; estas manifestaciones alteran la forma en que el individuo se comporta, en tanto que, el riesgo suicida es la posibilidad de que un sujeto atente contra su vida. La presente investigación tuvo como objetivo determinar la relación entre ansiedad y riesgo suicida en estudiantes universitarios, mediante un estudio no experimental, de tipo cuantitativo con un corte transversal y de alcance descriptivo-correlacional. Tuvo como participantes a 362 estudiantes, de los cuales 282 (77.9%) mujeres y 80 (22.1%) hombres, seleccionados a través de criterios de inclusión y exclusión mediante un muestreo no probabilístico por conveniencia. Se aplicó la Escala de Ansiedad de Beck (BAI) y la Escala de Riesgo Suicida de Plutchik (ERSP). Los resultados mostraron que existe correlación positiva leve entre ansiedad y riesgo suicida (Rho=0.638, p<0.001), concluyendo que, a mayor presencia de ansiedad, mayor es el riesgo de suicidio en la muestra.