bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk Stratification, Measurable Residual Disease, and Outcomes of AML Patients with a Trisomy 8 Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Authors: Backhaus Donata , Jentzsch Madlen , Bischof Lara , Brauer Dominic , Wilhelm Christina , Schulz Julia , Franke Georg-Nikolaus , Pönisch Wolfram , Vucinic Vladan , Platzbecker Uwe , Schwind Sebastian
Published: November 2021

Background: For most patients with acute myeloid leukemia (AML) harboring a trisomy 8 an allogeneic hematopoietic stem cell transplantation (HSCT) is a suitable and recommended consolidation therapy. However, comparative outcome analyses between patients with and without trisomy 8 undergoing allogeneic HSCT have not been performed so far. Methods: We retrospectively analyzed clinical features, outcomes, and measurable residual disease (MRD) of 659 AML (12%, n = 81, with a trisomy 8) patients subjected to allogeneic HSCT as a consolidation therapy. Results: The presence of a trisomy 8 associated with a trend for higher age at diagnosis, AML of secondary origin, lower white blood cell counts at diagnosis, worse ELN2017 genetic risk, wild-type NPM1, and mutated IDH1/2 and JAK2. Outcomes after allogeneic HSCT in the entire cohort did not differ between patients with a sole trisomy 8, trisomy 8 with additional cytogenetic aberrations or without a trisomy 8. A trisomy 8 did not affect outcomes within the three ELN2017 risk groups. In accordance with findings in unselected patient cohorts, persistent MRD at allogeneic HSCT in patients with a trisomy 8 identified individuals with a higher risk of relapse following allogeneic HSCT. Conclusions: Outcomes of trisomy 8 patients after allogeneic HSCT did not compare unfavorably to that of other AML patients following allogeneic HSCT. Rather than the presence or absence of a trisomy 8, additional genetic aberrations and MRD at HSCT define outcome differences and aid in informed treatment decisions.
Radiomics Predicts for Distant Metastasis in Locally Advanced Human Papillomavirus-Positive Oropharyngeal Squamous Cell Carcinoma
Authors: Rich Benjamin , Huang Jianfeng , Yang Yidong , Jin William , Johnson Perry , Wang Lora , Yang Fei
Published: November 2021

(1) Background and purpose: clinical trials have unsuccessfully tried to de-escalate treatment in locally advanced human papillomavirus positive (HPV+) oropharyngeal squamous cell carcinoma (OPSCC) with the goal of reducing treatment toxicity. The aim of this study was to explore the role of radiomics for risk stratification in this patient population to guide treatment. (2) Methods: the study population consisted of 225 patients with locally advanced HPV+ OPSCC treated with curative-intent radiation or chemoradiation therapy. Appearance of distant metastasis was used as the endpoint event. Radiomics data were extracted from the gross tumor volumes (GTVs) identified on the planning CT, with gray level being discretized using three different bin widths (8, 16, and 32). The data extracted for the groups with and without distant metastasis were subsequently balanced using three different algorithms including synthetic minority over-sampling technique (SMOTE), adaptive synthetic sampling (ADASYN), and borderline SMOTE. From these different combinations, a total of nine radiomics datasets were derived. Top features that minimized redundancy while maximizing relevance to the endpoint were selected individually and collectively for the nine radiomics datasets to build support vector machine (SVM) based predictive classifiers. Performance of the developed classifiers was evaluated by receiver operating characteristic (ROC) curve analysis. (3) Results: of the 225 locally advanced HPV+ OPSCC patients being studied, 9.3% had developed distant metastases at last follow-up. SVM classifiers built for the nine radiomics dataset using either their own respective top features or the top consensus ones were all able to differentiate the two cohorts at a level of excellence or beyond, with ROC area under curve (AUC) ranging from 0.84 to 0.95 (median = 0.90). ROC comparisons further revealed that the majority of the built classifiers did not distinguish the two cohorts significantly better than each other. (4) Conclusions: radiomics demonstrated discriminative ability in distinguishing patients with locally advanced HPV+ OPSCC who went on to develop distant metastasis after completion of definitive chemoradiation or radiation alone and may serve to risk stratify this patient population with the purpose of guiding the appropriate therapy.
Small but Challenging Conjunctival Melanoma: New Insights, Paradigms and Future Perspectives
Authors: Nahon-Estève Sacha , Bertolotto Corine , Picard-Gauci Alexandra , Gastaud Lauris , Baillif Stéphanie , Hofman Paul , Groulier Anaïs , Maschi Célia , Caujolle Jean-Pierre , Lassalle Sandra , Martel Arnaud
Published: November 2021

Although its incidence has increased over the last decades, conjunctival melanoma (CM) remains a rare but challenging periocular malignancy. While there is currently no recognized standard of care, “no-touch” surgical excision followed by adjuvant treatments is usually recommended. Despite its small size, managing CM is challenging for clinicians. The first challenge is the high risk of tumour local recurrence that occurs in about one third of the patients. The management of locally advanced CM (≥T2) or multiple recurrences may require mutilating surgeries such as orbital exenteration (OE). The second challenge is the metastatic spread of CM that occurs in about one quarter of patients, regardless of whether complete surgical excision is performed or not. This highlights the infiltrative and highly aggressive behaviour of CM. Recently, attention has been directed towards the use of eye-sparing strategies to avoid OE. Initially, wide conservative surgeries followed by customized brachytherapy or radiotherapy have appeared as viable strategies. Nowadays, new biological insights into CM have revealed similarities with cutaneous melanoma. These new findings have allowed clinicians to reconsider the management of locally advanced CM with “medical” eye-sparing treatment as well as the management of metastatic spread. The aim of this review was to summarize the current and future perspectives of treatment for CM based on recent biological findings.
The Endocannabinoid System as a Pharmacological Target for New Cancer Therapies
Authors: Ramer Robert , Wittig Felix , Hinz Burkhard
Published: November 2021

Despite the long history of cannabinoid use for medicinal and ritual purposes, an endogenous system of cannabinoid-controlled receptors, as well as their ligands and the enzymes that synthesise and degrade them, was only discovered in the 1990s. Since then, the endocannabinoid system has attracted widespread scientific interest regarding new pharmacological targets in cancer treatment among other reasons. Meanwhile, extensive preclinical studies have shown that cannabinoids have an inhibitory effect on tumour cell proliferation, tumour invasion, metastasis, angiogenesis, chemoresistance and epithelial-mesenchymal transition (EMT) and induce tumour cell apoptosis and autophagy as well as immune response. Appropriate cannabinoid compounds could moreover be useful for cancer patients as potential combination partners with other chemotherapeutic agents to increase their efficacy while reducing unwanted side effects. In addition to the direct activation of cannabinoid receptors through the exogenous application of corresponding agonists, another strategy is to activate these receptors by increasing the endocannabinoid levels at the corresponding pathological hotspots. Indeed, a number of studies accordingly showed an inhibitory effect of blockers of the endocannabinoid-degrading enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) on tumour development and spread. This review summarises the relevant preclinical studies with FAAH and MAGL inhibitors compared to studies with cannabinoids and provides an overview of the regulation of the endocannabinoid system in cancer.
Thermality versus Objectivity: Can They Peacefully Coexist?
Authors: Le Thao P. , Winter Andreas , Adesso Gerardo
Published: November 2021

Under the influence of external environments, quantum systems can undergo various different processes, including decoherence and equilibration. We observe that macroscopic objects are both objective and thermal, thus leading to the expectation that both objectivity and thermalisation can peacefully coexist on the quantum regime too. Crucially, however, objectivity relies on distributed classical information that could conflict with thermalisation. Here, we examine the overlap between thermal and objective states. We find that in general, one cannot exist when the other is present. However, there are certain regimes where thermality and objectivity are more likely to coexist: in the high temperature limit, at the non-degenerate low temperature limit, and when the environment is large. This is consistent with our experiences that everyday-sized objects can be both thermal and objective.
Voltage Unbalance, Power Factor and Losses Optimization in Electrified Railways Using an Electronic Balancer
Authors: Martins António P. , Rodrigues Pedro , Hassan Mahmoud , Morais Vítor A.
Published: November 2021

Unbalanced currents, low power factor and high losses contribute to increasing the bill infrastructure managers must pay to the TSO/DSO operator that supplies electric energy to the railway system. Additionally, if regenerative energy coming from braking regimes is not allowed to be injected into the grid or even is penalized when it occurs, then the optimization of those parameters must be pursued. One of the possible measures that can be taken to counteract those phenomena is the installation of electronic balancers in heavy loaded substations in order to optimize the interface to the three-phase electric grid. This paper shows the benefit of such use taking examples from real conditions and realistic simulations assumed equivalent to field measurements.
Low-Emissivity Window Films as an Energy Retrofit Option for a Historical Stone Building in Cold Climate
Authors: Moghaddam Saman Abolghasemi , Mattsson Magnus , Ameen Arman , Akander Jan , Gameiro Da Silva Manuel , Simões Nuno
Published: November 2021

Low-emissivity (low-E) window films are designed to improve the thermal comfort and energy performance of buildings. These films can be applied to different glazing systems without having to change the whole window. This makes it possible to apply films to windows in old and historical buildings for which preservation regulations often require that windows should remain unchanged. This research aims to investigate the impacts of low-E window films on the energy performance and thermal comfort of a three-story historical stone building in the cold climate of Sweden using the simulation software “IDA ICE”. On-site measurements were taken to acquire thermal and optical properties of the windows. This research shows that the application of the low-emissivity window film on the outward-facing surface of the inner pane of the double-glazed windows helped to reduce heat loss through the windows in winter and unwanted heat gains in summer by almost 36% and 35%, respectively. This resulted in a 6% reduction in the building’s annual energy consumption for heating purposes and a reduction in the percentage of total occupant hours with thermal dissatisfaction from 14% (without the film) to 11% (with the film). However, the relatively high price of the films and low price of district heating results in a rather long payback period of around 30 years. Thus, the films seem scarcely attractive from a purely economic viewpoint, but may be warranted for energy/environmental and thermal comfort reasons.
Analysis of Office Rooms Energy Consumption Data in Respect to Meteorological and Direct Sun Exposure Conditions
Authors: Kula Adam , Smalcerz Albert , Sajkowski Maciej , Kamiński Zygmunt
Published: November 2021

There are many papers concerning the consumption of energy in different buildings. Most describe residential buildings, with only a few about office- or public service buildings. Few articles showcase the use of energy consumption in specific rooms of a building, directed in different geographical directions. On the other hand, many publications present methods, such as machine learning or AI, for building energy management and prediction of its consumption. These methods have limitations and represent a certain level of uncertainty. In order to compare energy consumption of different rooms, the measurements of particular building-room parameters were collected and analyzed. The obtained results showcase the effect of room location, regarding geographical directions, for the consumption of energy for heating. For south-exposed rooms, due to sun radiation, it is possible to switch heating off completely, and even overheating of 3 °C above the 22 °C temperature set point occurs. The impact of the sun radiation for rooms with a window directed east or west reached about 1 °C and lasts for a few hours before noon for the east, and until late afternoon for the west.
Capabilities of Nearly Zero Energy Building (nZEB) Electricity Generation to Charge Electric Vehicle (EV) Operating in Real Driving Conditions (RDC)
Authors: Cieslik Wojciech , Szwajca Filip , Zawartowski Jedrzej , Pietrzak Katarzyna , Rosolski Slawomir , Szkarlat Kamil , Rutkowski Michal
Published: November 2021

The growing number of electric vehicles in recent years is observable in almost all countries. The country’s energy transition should accompany this rise in electromobility if it is currently generated from non-renewable sources. Only electric vehicles powered by renewable energy sources can be considered zero-emission. Therefore, it is essential to conduct interdisciplinary research on the feasibility of combining energy recovery/generation structures and testing the energy consumption of electric vehicles under real driving conditions. This work presents a comprehensive approach for evaluating the energy consumption of a modern public building–electric vehicle system within a specific location. The original methodology developed includes surveys that demonstrate the required mobility range to be provided to occupants of the building under consideration. In the next step, an energy balance was performed for a novel near-zero energy building equipped with a 199.8 kWp photovoltaic installation, the energy from which can be used to charge an electric vehicle. The analysis considered the variation in vehicle energy consumption by season (winter/summer), the actual charging profile of the vehicle, and the parking periods required to achieve the target range for the user.
Energy Efficiency and Smooth Running of a Train on the Route While Approaching Another Train
Authors: Szkopiński Janusz , Kochan Andrzej
Published: November 2021

This paper presents an innovative technique of traffic management on a route divided into fixed block distances for trains equipped with a continuous area data transmission system that ensures information exchange between a train and a control center. The originality of the technique is focused on the optimization of the following train’s speed profile in terms of energy consumption under the need to maintain a minimum distance to the preceding train and to assume the smooth running of the following train, using elements of fixed and mobile block distance methods. The obtained results are an answer to the question of whether it is possible to obtain a smoother movement of the train and savings in mechanical energy consumption if the speed profile of this train is adjusted to the conditions before the train, such as information about the speed of the preceding train.
Numerical Simulation of the Effects of Oil Gun Location and Oil Feed Rate on Coal Ignition and Burner Wall Temperature in a Tiny Oil Ignition Burner
Authors: Ma Qilei , Zhong Wenqi , Chen Xi , Li Jianhua , Zhang Hui
Published: November 2021

To solve the overheating problem of tiny oil ignition burners’ walls during the firing-up process in a 330 MWe tangentially pulverized coal-fired boiler, a numerical model of a tiny oil ignition burner was carefully built considering combustion, gas–solid flow, and heat transfer. Then, the burner location and oil feed rate were optimized based on the model to prevent the burner’s walls from overheating. The effects of the oil gun extension distance (100, 200, 300, 400, 500 mm) and oil feed rate (160, 140, 120, 100, 80, 70, 60 kg/h) on coal ignition performance and burner wall temperature were carefully investigated. The simulation results showed good agreement with the measured results. The results indicated that decreasing the oil gun distance within the burner diminished the flame length of the co-combustion of oil and pulverized coal, thus lowering the burner wall temperature. Decreasing the oil feed rate appropriately could also reduce the burner wall temperature without influencing the ignition performance. Considering both ignition performance and burner wall temperature, an extension of 400 mm of the oil gun location and an oil feed rate of 160 kg/h were successfully applied to the actual operation without adverse effects. Moreover, it is suggested to move the temperature monitor points from the burner upper wall to the burner side wall.
Recent Advances of Film–Forming Kinetics in Organic Solar Cells
Authors: Liang Qiuju , Yao Jianhong , Hu Zhangbo , Wei Puxin , Lu Haodong , Yin Yukai , Wang Kang , Liu Jiangang
Published: November 2021

Solution–processed organic solar cells (OSC) have been explored widely due to their low cost and convenience, and impressive power conversion efficiencies (PCEs) which have surpassed 18%. In particular, the optimization of film morphology, including the phase separation structure and crystallinity degree of donor and acceptor domains, is crucially important to the improvement in PCE. Considering that the film morphology optimization of many blends can be achieved by regulating the film–forming process, it is necessary to take note of the employment of solvents and additives used during film processing, as well as the film–forming conditions. Herein, we summarize the recent investigations about thin films and expect to give some guidance for its prospective progress. The different film morphologies are discussed in detail to reveal the relationship between the morphology and device performance. Then, the principle of morphology regulating is concluded with. Finally, a future controlling of the film morphology and development is briefly outlined, which may provide some guidance for further optimizing the device performance.
Power Profile and Thresholding Assisted Multi-Label NILM Classification
Authors: Rehmani Muhammad , Aslam Saad , Tito Shafiqur , Soltic Snjezana , Nieuwoudt Pieter , Pandey Neel , Ahmed Mollah
Published: November 2021

Next-generation power systems aim at optimizing the energy consumption of household appliances by utilising computationally intelligent techniques, referred to as load monitoring. Non-intrusive load monitoring (NILM) is considered to be one of the most cost-effective methods for load classification. The objective is to segregate the energy consumption of individual appliances from their aggregated energy consumption. The extracted energy consumption of individual devices can then be used to achieve demand-side management and energy saving through optimal load management strategies. Machine learning (ML) has been popularly used to solve many complex problems including NILM. With the availability of the energy consumption datasets, various ML algorithms have been effectively trained and tested. However, most of the current methodologies for NILM employ neural networks only for a limited operational output level of appliances and their combinations (i.e., only for a small number of classes). On the contrary, this work depicts a more practical scenario where over a hundred different combinations were considered and labelled for the training and testing of various machine learning algorithms. Moreover, two novel concepts—i.e., thresholding/occurrence per million (OPM) along with power windowing—were utilised, which significantly improved the performance of the trained algorithms. All the trained algorithms were thoroughly evaluated using various performance parameters. The results shown demonstrate the effectiveness of thresholding and OPM concepts in classifying concurrently operating appliances using ML.
Editorial and Ideas for Research Using Mathematical and Statistical Models for Energy with Applications
Authors: Islam Faridul , Tiwari Aviral Kumar , Wong Wing-Keung
Published: November 2021

Given the mounting evidence favoring quantitative and qualitative analyses, prompted by easy access to data, mathematical and statistical models have gained a formal appreciation for their role in the analytical apparatus of contemporary research methodologies in all fields [...]
A Case Study on a Stochastic-Based Optimisation Approach towards the Integration of Photovoltaic Panels in Multi-Residential Social Housing
Authors: Oliveira Rui , Almeida Ricardo M.S.F. , Figueiredo António , Vicente Romeu
Published: November 2021

The socioeconomic reality and the energy retrofit potential of the social housing neighbourhoods in Portugal are stimulating challenges to be addressed by research to pursue suitable energy efficient strategies to be integrated into these buildings. Therefore, this study explored a stochastic-based optimisation approach towards the integration of photovoltaic (PV) panels, considering different scenarios that combine the occupancy rate, the internal gains, the envelope refurbishment and the heating system efficiency. The optimisation approach has as its objective the minimisation of the life cycle cost of the photovoltaic system while using a limited space area on the rooftop for its installation. This study allowed concluding that the use of passive measures such as improving the thermal performance of the building envelope is essential to attain a lower optimal-sizing of a photovoltaic installation. The results reveal a decreasing trend in the PV optimal sizing, attaining a reduction up to 30% of the total number of PV panels installed on the sloped rooftop in several scenarios with 50% of occupancy rate. However, the impact can be greater when passive measures are coupled to more efficient heating systems, with higher COP, which result in a decrease up to 64% of the number of PV panels. Thus, the approach proposed is of paramount importance to aid in the decision-making process of design and sizing of photovoltaic installation, highlighting the practical application potential for social housing and a contribution for mitigation of the energy poverty of low-income families that live in these buildings.
Electric Vehicle Fleets as Balancing Instrument in Micro-Grids
Authors: Gruosso Giambattista , Ruiz Fredy Orlando
Published: November 2021

Micro-grids have become the building block of modern energy systems, where distributed resources are the characterizing feature. The charging operation of electric vehicles can be exploited as a flexible load to achieve operational goals of the micro-grid. In the particular case of car-sharing fleets, the degrees of freedom in the charging procedures are reduced when compared to private users. In this work, we illustrate how a car sharing fleet can be incorporated as a flexible load in the micro-grid management system. A linear optimization problem is formulated, where the cost function makes a trade-off between the gain in flexibility in the micro-grid and the loss incurred by the car-sharing service for delaying the recharging procedure of the EV. The proposed approach is evaluated on a data set of charging events generated by a real car-sharing fleet showing that the EMS allows reducing the daily peak demand requested to the public grid and diminishes the operational costs.
The Concept of Using LSTM to Detect Moisture in Brick Walls by Means of Electrical Impedance Tomography
Authors: Kłosowski Grzegorz , Hoła Anna , Rymarczyk Tomasz , Skowron Łukasz , Wołowiec Tomasz , Kowalski Marcin
Published: November 2021

This paper refers to an original concept of tomographic measurement of brick wall humidity using an algorithm based on long short-term memory (LSTM) neural networks. The measurement vector was treated as a data sequence with a single time step in the presented study. This approach enabled the use of an algorithm utilising a recurrent deep neural network of the LSTM type as a system for converting the measurement vector into output images. A prototype electrical impedance tomograph was used in the research. The LSTM network, which is often employed for time series classification, was used to tackle the inverse problem. The task of the LSTM network was to convert 448 voltage measurements into spatial images of a selected section of a historical building’s brick wall. The 3D tomographic image mesh consisted of 11,297 finite elements. A novelty is using the measurement vector as a single time step sequence consisting of 448 features (channels). Through the appropriate selection of network parameters and the training algorithm, it was possible to obtain an LSTM network that reconstructs images of damp brick walls with high accuracy. Additionally, the reconstruction times are very short.
Exploring the Association between Alcohol Drinking and Physical Activity in Adolescence; Two-Year Prospective Study in Younger Adolescents from Bosnia and Herzegovina
Authors: Zenic Natasa , Lipowska Małgorzata , Maric Dora , Versic Sime , Vlahovic Hrvoje , Gilic Barbara
Published: November 2021

Insufficient physical activity and alcohol consumption (AC) are important health-threatening behaviors in adolescence, but there are controversial findings regarding the association that may exist between AC and physical activity levels (PALs) at this age. This study aimed to prospectively examine the relationship that may exist between AC and PAL in younger adolescence, considering the potential confounding effect of sports participation. The participants (n = 669, 337 females) were adolescents from Bosnia and Herzegovina who were tested on two occasions, at baseline (14 years of age) and again at follow-up (16 years of age). The variables included AC (as indicated by the AUDIT questionnaire), sports participation, age, gender (predictors), and PAL (obtained by the PAQ-A questionnaire) criterion. The results indicated that PAL at baseline was higher in those adolescents (boys) with a higher AUDIT score, but this association was partially confounded by sports participation. Multinomial regression indicated a higher risk of a decline in PAL over the study course in adolescents with a higher AUDIT score at baseline (OR = 1.32, 95%CI: 1.11–1.54 for being in the high-risk group for a decline in PAL). The most probable explanation is likely found in the high drop-out from sports in the studied period and earlier initiation of AC in adolescents involved in sports. Public health and sports authorities should urgently act preventively and develop educational programs against alcohol drinking in youth athletes.
The Role of Animal Ownership for People with Severe Mental Illness during the COVID-19 Pandemic: A Mixed-Method Study Investigating Links with Health and Loneliness
Authors: Shoesmith Emily , Spanakis Panagiotis , Peckham Emily , Heron Paul , Johnston Gordon , Walker Lauren , Crosland Suzanne , Ratschen Elena
Published: November 2021

Research has reported the benefits of companion animals for people with severe mental illness (SMI). However, this evidence base is fragmented and unclear. The COVID-19 pandemic presents an opportunity to explore the role of companion animals in the context of social distancing and isolation measures for people with SMI. Therefore, we aimed to investigate the links between mental and physical health and animal ownership in people with SMI and to explore animal owners’ perceptions related to human–animal interactions during the pandemic restrictions. A survey was conducted with a previously assembled cohort of individuals with SMI in the UK. The survey included previously validated and new bespoke items measuring demographics, and outcomes related to mental and physical health, and human–animal interactions. The survey also included a question inviting free-text responses, allowing participants to describe any experiences of their human–animal relationships during the pandemic. Of 315 participants who consented to participate, 249 (79%) completed the survey. Of these, 115 (46.2%) had at least one companion animal. Regression analyses indicated that animal ownership was not significantly associated with well-being and loneliness. However, animal ownership was associated with a self-reported decline in mental health (b = 0.640, 95% CI [0.102–1.231], p = 0.025), but no self-reported change in physical health. Thematic analysis identified two main themes relating to the positive and negative impact of animal ownership during pandemic restrictions. Animal ownership appeared to be linked to self-reported mental health decline in people with SMI during the second wave of the pandemic in the UK. However, the thematic analysis also highlighted the perceived benefit of animal ownership during this time. Further targeted investigation of the role of human–animal relationships and the perceived human–animal bond for human health is warranted.
Sexual Victimization Disclosure: A Cluster Analysis Approach to Understanding Victimization Experiences in Disclosers and Non-Disclosers
Authors: Carson Kaitlin Walsh , Babad Sara , Kosuri Mahathi , Bursky Mikell , Fairchild Victoria , Barahmand Usha , Brown Elissa J. , Nikulina Valentina
Published: November 2021

Research has used cluster analysis to identify clusters, or groups, of sexual victimization survivors who share similar assault experiences. However, researchers have not investigated whether disclosure status is a key component of the survivors’ experience. The current study identified two clusters among 174 disclosing and non-disclosing sexual victimization survivors. Cluster One (n = 74) included an incapacitated assault by a lesser-known perpetrator and disclosure of the event. Cluster Two (n = 100) included a verbally instigated assault by a well-known perpetrator and nondisclosure of the event. Follow up independent t-tests revealed that women in Cluster One had significantly higher depression and posttraumatic stress disorder (PTSD) symptoms than women in Cluster Two. Results support prior research identifying clusters of victimization based on assault characteristics and suggest that disclosure status is a key variable in the recovery process. Specific implications for clinicians, policy makers, and the community are discussed.
The Integration of Gender Perspective into Young People’s Sexuality Education in Spain and Portugal: Legislation and Educational Models
Authors: Cunha-Oliveira Aliete , Camarneiro Ana Paula , Gómez-Cantarino Sagrario , Cipriano-Crespo Carmen , Queirós Paulo Joaquim Pina , Cardoso Daniela , Santos Diana Gabriela , Ugarte-Gurrutxaga María Idoia
Published: November 2021

Throughout history, Sexuality Education (SE) has undergone many changes in formal education curricula. The education systems should incorporate SE and promote an understanding of sexuality from the critical perspective of gender. Objectives: To examine the approach to SE in young people in Spain and Portugal, considering the incorporation of the gender perspective, and analyze the legislation in both countries. A scoping review was conducted considering studies with SE programs, gender perspective, and legislation in Spanish, Portuguese, and English, without any time limits. The population consisted of young people aged 10 to 18 years who did not attend higher education. Databases used: CINAHL Complete, ERIC, LILACS, SciELO, MEDLINE, Psychology and Behavioral Sciences Collection, Scopus, Open Access Scientific Repository of Portugal, Base de Datos de Tesis Doctorales, Theses and Dissertations Online, and governmental websites. Thirty-two studies were found, including intervention, diagnosis, and documental programs. Eight of the studies adopted the gender perspective. Legislation in both countries is vast, with 23 main references. Although SE is legislated in both countries, the social-health and educational programs are insufficient. The relevance of the gender perspective is not incorporated into SE.
The Relationship between Leg Extension Angle at Late Stance and Knee Flexion Angle at Swing Phase during Gait in Community-Dwelling Older Adults
Authors: Miyazaki Takasuke , Kiyama Ryoji , Nakai Yuki , Kawada Masayuki , Takeshita Yasufumi , Araki Sota , Hayashi Hiroyuki , Higashi Naoto , Makizako Hyuma
Published: November 2021

This study aimed to clarify the relationship between leg extension angle and knee flexion angle during gait in older adults. The subjects of this cross-sectional study were 588 community-dwelling older adults (74.6 ± 6.1 y). Segment angles and acceleration were measured using five inertial measurement units during comfortable gait, and bilateral knee and hip joint angles, and leg extension angle, reflecting whole lower limb extension at late stance, were calculated. Propulsion force was estimated using the increase in velocity calculated from anterior acceleration of the sacrum during late stance. Correlation analysis showed that leg extension angle was associated with knee flexion angle at swing phase and hip extension angle and increase in velocity at late stance (r = 0.444–508, p < 0.001). Multiple regression analysis showed that knee flexion angle at mid-swing was more affected by leg extension angle (β = 0.296, p < 0.001) than by gait speed (β = 0.219, p < 0.001) and maximum hip extension angle (β = −0.150, p < 0.001). These findings indicate that leg extension angle may be a meaningful parameter for improving gait function in older adults due to the association with knee kinematics during swing as well as propulsion force at late stance.
Create Solidarity Networks: Dialogs in Reddit to Overcome Depression and Suicidal Ideation among Males
Authors: Redondo-Sama Gisela , Morlà-Folch Teresa , Burgués Ana , Amador Jelen , Magaraggia Sveva
Published: November 2021

The emerging scientific literature examines masculinity and gender roles as risk factors for suicide ideation or suicide in young adults and adolescents. In this vein, recent studies show that certain traditional masculine norms are related to poorer mental health-related outcomes, which influences suicide and suicide ideation. This study contributes with new understandings about the associations between masculinity and suicidal ideation among males through Reddit debates in English. The posts with more interactions referring to masculinity in the topics gender and education have been selected on Reddit, emphasizing transformative personal experiences potentially helping avoid suicide ideation. Through the analysis of Reddit posts, it is shown how users can generate spaces to express the diverse ways to live with masculinity. The discussions on Reddit in the different areas selected demonstrate the existence of proposals on how to overcome fears and facilitate relaxation of norms regarding self-reliance to encourage help-seeking when feeling depressed and therefore at greater risk of suicide ideation. The results highlight the potential importance of platforms such as Reddit to create solidarity networks, showing multiple ways of being a man and demystifying dominant masculinity by sharing different experiences.
Influence of Football Match-Play on Isometric Knee Flexion Strength and Passive Hip Flexion Range of Motion in Football Referees and Assistant Referees
Authors: Fernández-Ruiz Vicente , López-Samanes Álvaro , Del Coso Juan , Pino-Ortega José , Sánchez-Sánchez Javier , Terrón-Manrique Pablo , Beato Marco , Moreno-Pérez Víctor
Published: November 2021

The aim of this study was to examine the acute effect of officiating a football (soccer) match on isometric knee flexion strength and passive hip flexion range-of-motion (ROM) in referees and assistant football referees. Twelve referees (25.3 ± 3.3 years) and twenty-three assistant referees (25.1 ± 4.8 years) underwent measurements on isometric knee flexion strength and passive hip flexion ROM before and after officiating an official football match. Referees’ and assistant referees’ running patterns were monitored during the match using GPS technology. In comparison to pre-match values, referees reduced their isometric knee flexion strength (−12.36%, p = 0.046, Effect size [ES] = −0.36) in the non-dominant limb, while no significant differences were reported in the dominant limb (−0.75%, p = 0.833, ES = −0.02). No effect of the match was found in hip flexion ROM values in dominant (−4.78%, p = 0.102, ES = −0.15) and non-dominant limb (5.54%, p = 0.544, ES = 0.19). In assistant referees, the pre-to-post-match changes in isometric knee flexion strength (dominant limb −3.10%, p = 0.323, ES = −0.13; non-dominant limb −2.18%, p = 0.980, ES= 0.00) and hip flexion ROM (dominant limb 1.90% p = −0.816, ES = 0.13; non-dominant limb 3.22% p = 0.051, ES = 0.23) did not reach statistical significance. Officiating a match provoked a reduction in isometric knee flexion strength in the non-dominant limb of football referees, while no differences were reported in assistant referees.
Mapping Biological Risks Related to Necropsy Activities: Old Concerns and Novel Issues for the Safety of Health Professionals
Authors: Tomao Paola , La Russa Raffaele , Oliva Alessandra , De Angelis Massimiliano , Mansi Antonella , Paba Emilia , Marcelloni Anna Maria , Chiominto Alessandra , Padovano Martina , Maiese Aniello , Scopetti Matteo , Frati Paola , Fineschi Vittorio
Published: November 2021

Nowadays only a few studies on biological and environmental risk among healthcare workers are available in literature. The present study aims to assess the health operator’s risk of contact with microorganisms during necropsy activities, to evaluate the efficiency of current protections, to identify possible new sources of contact, and to point out possible preventive measures. In addition, considering the current pandemic scenario, the risk of transmission of SARS-CoV-2 infection in the dissection room is assessed. The objectives were pursued through two distinct monitoring campaigns carried out in different periods through sampling performed both on the corpses and at the environmental level.
Modeling Effects of Spatial Heterogeneities and Layered Exposure Interventions on the Spread of COVID-19 across New Jersey
Authors: Ren Xiang , Weisel Clifford P. , Georgopoulos Panos G.
Published: November 2021

COVID-19 created an unprecedented global public health crisis during 2020–2021. The severity of the fast-spreading infection, combined with uncertainties regarding the physical and biological processes affecting transmission of SARS-CoV-2, posed enormous challenges to healthcare systems. Pandemic dynamics exhibited complex spatial heterogeneities across multiple scales, as local demographic, socioeconomic, behavioral and environmental factors were modulating population exposures and susceptibilities. Before effective pharmacological interventions became available, controlling exposures to SARS-CoV-2 was the only public health option for mitigating the disease; therefore, models quantifying the impacts of heterogeneities and alternative exposure interventions on COVID-19 outcomes became essential tools informing policy development. This study used a stochastic SEIR framework, modeling each of the 21 New Jersey counties, to capture important heterogeneities of COVID-19 outcomes across the State. The models were calibrated using confirmed daily deaths and SQMC optimization and subsequently applied in predictive and exploratory modes. The predictions achieved good agreement between modeled and reported death data; counterfactual analysis was performed to assess the effectiveness of layered interventions on reducing exposures to SARS-CoV-2 and thereby fatality of COVID-19. The modeling analysis of the reduction in exposures to SARS-CoV-2 achieved through concurrent social distancing and face-mask wearing estimated that 357 [IQR (290, 429)] deaths per 100,000 people were averted.
Measuring COVID-19 Related Health Literacy in Healthcare Professionals—Psychometric Evaluation of the HL-COV-HP Instrument
Authors: Hiltrop Kati , Hiebel Nina , Geiser Franziska , Kriegsmann-Rabe Milena , Gambashidze Nikoloz , Morawa Eva , Erim Yesim , Weidner Kerstin , Albus Christian , Ernstmann Nicole
Published: November 2021

Background: Thus far, there is no instrument available measuring COVID-19 related health literacy of healthcare professionals. Therefore, the aim of this study was to develop an instrument assessing COVID-19 related health literacy in healthcare professionals (HL-COV-HP) and evaluate its psychometric properties. Methods: An exploratory factor analysis, a confirmatory factor analysis, and descriptive analyses were conducted using data from n = 965 healthcare professionals. Health literacy related to COVID-19 was measured with 12 items, which were adapted from the validated HLS-EU-Q16 instrument measuring general health literacy. Results: Exploratory factor analysis demonstrated that 12 items loaded on one component. After removing one item due to its high standardized residual covariance, the confirmatory factor analysis of a one-factor model with 11 items showed satisfactory model fit (χ2 = 199.340, df = 41, χ2/df = 4.862, p < 0.001, RMSEA = 0.063, CFI = 0.963 and TLI = 0.951). The HL-COV-HP instrument showed good internal consistency (Cronbach’s alpha 0.87) and acceptable construct reliability. Conclusions: The HL-COV-HP is a reliable, valid, and feasible instrument to assess the COVID-19 related health literacy in healthcare professionals. It can be used in hospitals or other healt hcare settings to assess the motivation and ability of healthcare professionals to find, understand, evaluate, and use COVID-19 information.
Support through Social Media and Online Class Participation to Enhance Psychological Resilience
Authors: Asghar Muhammad Zaheer , Arif Seema , Barbera Elena , Seitamaa-Hakkarainen Pirita , Kocayoruk Ercan
Published: November 2021

Social support was an important factor in minimizing the effect of social isolation during the COVID-19 pandemic lockdown. This research aimed to study the role of online class participation and social media usage to link the social support available from family and friends to psychological resilience among pre-service special education teachers against the negative psychological effects of the COVID-19 pandemic lockdown. A survey was conducted with 377 pre-service special needs education (SNE) teachers enrolled at universities in Pakistan. Partial least square structural equation modeling (PLS-SEM) was applied using Smart-PLS 3.2.8. Results revealed that social media and online class participation played a mediating role between social support and psychological resilience in the pre-service special needs education (SNE) teachers studied. Teacher education institutions can devise strategies to develop social media platforms for student socialization during an emergency to help build resilience against the negative psychological effects of social isolation. Future studies could be conducted to adapt instructions and curricula to social media environments for education in an emergency.
A Hybrid Framework for Direct CO2 Emissions Quantification in China’s Construction Sector
Authors: Ogungbile Adedayo Johnson , Shen Geoffrey Qiping , Wuni Ibrahim Yahaya , Xue Jin , Hong Jingke
Published: November 2021

Carbon emission quantifications in China are not consistent, with many standards and methods having been used over the years. This study identified the non-consideration of China-specific technology and databases as a factor limiting comprehensive quantification. The study aimed to comprehensively quantify regional direct CO2 emission in the industry using a hybrid of economic and environmental data. We retrieved nineteen (19) sets of fossil fuel and electricity data from provincial energy yearbooks between 1997 and 2015 for the study. To generate regression models for each of the six regional construction industries in China, the study further integrated the results with three sets of econometric data: total annual construction output, cement, and steel product yearly consumption data. The study identified the North China region as the main source of direct CO2 emission with over 30%, while Southeast China contributed the least. While there is a gradual shift to other energy sources, the study identified coal and crude oil to remain as the main energy sources in the industry. Cement and steel data exhibited a significant predictive relationship with CO2 emissions in five regional construction industries. The study identified the need to have policies tailored to technological improvements to enhance renewable energy generation and usage in the industry. The models developed in this study could be used to generate initial quantifications of carbon emissions in construction industries with similar carbon-emitting characteristics for carbon tracking, and energy policies for decision making. However, the three economic indicators used in the study could be extended to generate more robust models in future research.
Why We Eat the Way We Do: A Call to Consider Food Culture in Public Health Initiatives
Authors: Mingay Edwina , Hart Melissa , Yoong Serene , Hure Alexis
Published: November 2021

The way we eat has changed dramatically in only a few decades. While definitions of food culture have previously existed, a clear description of modern food culture that can be used for health promotion is lacking. In this paper, we propose a concept of food culture for application within public health, what a positive food culture looks like compared to negative elements that have dominated in developed countries and the consequences for physical and mental health and wellbeing. We support calls to action from the international community to reconsider the way we eat. All segments of society have a role to play in building a positive food culture, and it is critical that macro (policy and systems) and meso (community) level environmental factors align and provide supportive environments that promote health-enhancing behaviours. Defining food culture is a necessary step towards articulating the complexities that influence food behaviours and impact health. The ultimate goal is collective action to enable population-wide and sustained improvements to the way we eat, and how we think and feel about food.
The Development of Telemedicine and eHealth in Surgery during the SARS-CoV-2 Pandemic
Authors: Taha Anas , Saad Bara , Enodien Bassey , Bachmann Marta , Frey Daniel M. , Taha-Mehlitz Stephanie
Published: November 2021

SARS-CoV-2 has hampered healthcare systems worldwide, but some countries have found new opportunities and methods to combat it. In this study, we focused on the rapid growth of telemedicine during the pandemic around the world. We conducted a systematic literature review of all the articles published up to the present year, 2021, by following the requirements of the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) framework. The data extracted comprised eHealth and telemedicine in surgery globally, and independently in Europe, the United States, and Switzerland. This review explicitly included fifty-nine studies. Out of all the articles included, none of them found that telemedicine causes poor outcomes in patients. Telemedicine has created a new path in the world of healthcare, revolutionizing how healthcare is delivered to patients and developing alternative methods for clinicians.