bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychosomatic disorder screening in health officers during the COVID-19 pandemic
Authors: Ardani Yanuar , Shatri Hamzah , Putranto Rudi , Sinulingga Dika Iyona , Faisal Edward , Anggono Rendi Faris
Published: November 2023

Background: Health workers are at high risk of developing depression, anxiety, and sleep disturbances due to increased stress during the COVID-19 pandemic; that matter is closely related to fatigue. The impact of psychosomatic disorders will have an immediate or indirect impact on the quality of health care services. This study aims to evaluate the psychosomatic disorder screening in health officers during the COVID-19 pandemic
Methods: A cross-sectional study was conducted in Esensia Clinic Semarang in February 2022. This study surveyed clinic health workers with completed questionnaires and had their Heart-Rate Variability (HRV) measurement. Data were analyzed using SPSS version 20 for Windows.
Results: About 138 subjects were recruited from Esensia Clinic, 100 subjects underwent this study until analysis. The unanxious subjects have the highest percentage accounting for 61.0%, followed by 25.0% mild anxiety, 12.0% moderate, and 2.0% severe. Furthermore, 86.0% were undepressed, followed by 13% mild and 1% moderate, but there was no severe case. Also, 65.0% did not experience fatigue and the percentage of good sleep quality (8.0%) is significantly lower than the poor (92.0%). The results also showed that 76.0% of the subjects had a balanced autonomic nervous system compared to the 24.0% of subjects with an autonomic imbalance.
Conclusion: The outcomes of psychosomatic disorders such as anxiety, depression, fatigue, and autonomic imbalance are generally poor. However, this study's prevalence of poor sleep quality was very high.
Hubungan kemampuan berpikir kritis terhadap keaktifan belajar pada mahasiswa sarjana kedokteran Universitas Udayana
Authors: Icha Milenia Yanwar  , I Gusti Ayu Sri Darmayani  , I Gde Haryo Ganesha  , I Putu Bayu Mayura
Published: November 2023

Introduction: Problem-based learning is a method of approach in assisting students in finding problems from a real event. This can affect learning methods to increase skills of critical thinking and active learning, where critical thinking will encourage the formation of knowledge and will be interpreted personally and will be applied to conditions or problems so as to increase active learning. This study aims to determine association between critical thinking skills towards active learning in medical students at Universitas Udayana.
Methods: The respondents of this study were medical students class 2020 in Universitas Udayana. The type of this research is analytic research with a cross-sectional approach. The sampling technique used was the total sampling method and used a questionnaire of critical thinking and active learning.
Results: A total of 165 respondents met the inclusion criteria in this research. The analysis results showed that critical thinking skills increased active learning significantly (p < 0.001) with moderate and direct correlation (r = 0.574).
Conclusion: The ability to think critically can affect the level of active learning in medical education students.
 
Pendahuluan: Salah satu metode pendekatan untuk membantu mahasiswa dalam menemukan masalah dari suatu peristiwa yang nyata adalah pembelajaran berbasis masalah. Hal ini dapat mempengaruhi metode belajar yang menyebabkan peningkatan kemampuan berpikir dan keaktifan belajar. Berpikir kritis akan mendorong terbentuknya pengetahuan dan akan diinterpretasi personal dan akan diaplikasikan pada kondisi atau masalah sehingga meningkatkan keaktifan belajar. Penelitian ini memiliki tujuan untuk menganalisis hubungan antara kemampuan berpikir kritis dan keaktifan belajar pada mahasiswa sarjana kedokteran Universitas Udayana.
Metode: Responden penelitian ini adalah mahasiswa program studi sarjana kedokteran Universitas Udayana angkatan 2020. Penelitian ini merupakan penelitian analitik dengan pendekatan potong lintang. Teknik pengambilan sampel dilakukan dengan total sampling dan menggunakan kuesioner berpikir kritis dan keaktifan belajar.
Hasil: Sebanyak 165 responden memenuhi kriteria inklusi dalam penelitian ini.  Hasil analisis menunjukkan bahwa kemampuan berpikir kritis meningkatkan keaktifan belajar secara signifikan (p < 0,001) dengan korelasi sedang dan searah (r = 0,574).
Simpulan: Kemampuan berpikir kritis dapat mempengaruhi tingkat keaktifan belajar pada mahasiswa sarjana kedokteran Universitas Udayana.
Low serum irisin levels in newly diagnosed patients with type 2 diabetes mellitus: a meta-analysis
Authors: Nurcahya I Gusti Ngurah Metta , Paramitha Ayu Agung Pradnya , Putrawan Ida Bagus Indra Wibawa , Wulandari Dewi Catur
Published: November 2023

Background: Low irisin levels, a marker widely reported to be associated with developing insulin resistance and type 2 diabetes mellitus. This study aims to provide evidence regarding irisin levels in patients newly diagnosed with type 2 diabetes mellitus.
Methods: A systematic review and meta-analysis of observational studies in adults over 18 newly diagnosed with type 2 diabetes mellitus. The databases used for this study were PubMed, ProQuest and ScienceDirect. Only English studies were considered in the database searched from the beginning to October 2022. The data obtained were analyzed using the RevMan 5.4 application.
Results: Twelve studies met the inclusion criteria. These were identified using a total of 1,621 patients with; 880 cases and 741 controls. This main point shows that the serum irisin level in patients newly diagnosed with type 2 diabetes mellitus has a mean difference of -7.72 with 95% CI -9.49 to -5.95. Since the evidence collected in our meta-analysis showed heterogeneity (I2 = 99%), a random effects model was performed. The z-test results for the overall effect were statistically significant (P≤0.001).
Conclusion: Irisin levels were significantly lower in patients newly diagnosed with type 2 diabetes mellitus than in the healthy group.
Prevalensi dan faktor risiko mask acne pada mahasiswa program studi sarjana kedokteran dan profesi dokter Universitas Udayana angkatan 2019-2021
Authors: Bella Trisha Agung Saraswati  , I Dewa Ayu Inten Dwi Primayanti  , Luh Putu Ratna Sundari  , I Putu Adiartha Griadhi
Published: November 2023

Introduction: One of the mandatory health protocols during the COVID-19 pandemic is wearing a mask. Masks that are used for a long time can increase the risk of developing acne vulgaris in the area around the mouth and nose (mask acne). The impact caused by acne masks is very detrimental both in terms of aesthetics, comfort, and psychology. This study aims to analyze the prevalence and risk factors for mask acne in undergraduate medical students and the medical profession at Udayana University class of 2019-2021.
Methods: This study has a cross-sectional design with observational analytic methods. The sample of this research was 260 respondents who were taken by consecutive sampling. Data analysis was performed by chi-square test and logistic regression.
Results: The prevalence of mask acne in students of the Faculty of Medicine, Udayana University class of 2019-2021 is 50.8%. Risk factors for mask acne in students of the Faculty of Medicine, Udayana University class of 2019-2021 include skin type (p = 0.025), oily skin condition after using a mask (p <0.001), and having a history of acne vulgaris due to sunlight (p = 0.002).
Conclusion: About half of the 2019-2021 class of Udayana University Faculty of Medicine students experience mask acne with various risk factors.
 
Pendahuluan: Salah satu protokol kesehatan saat pandemi COVID-19 yang wajib dilakukan adalah menggunakn masker. Masker yang digunakan dalam waktu lama dapat meningkatkan risiko timbulnya acne vulgaris di area sekitar mulut dan hidung (mask acne). Dampak yang ditimbulkan mask acne sangat merugikan baik dari segi estetika, kenyamanan, dan psikologis. Penelitian ini memiliki tujuan untuk menganalisis prevalensi dan faktor risiko mask acne pada mahasiswa program studi sarjana kedokteran dan profesi dokter Universitas Udayana angkatan 2019-2021.
Metode: Penelitian ini memiliki desain cross-sectional dengan metode analitik observasional. Sampel dari penelitian ini sebanyak 260 responden yang diambil dengan cara consecutive sampling. Analissi data dilakukan dengan uji chi-square dan regresi logistik.
Hasil: Prevalensi mask acne pada mahasiswa Fakultas Kedokteran Universitas Udayana angkatan 2019-2021 adalah 50,8%. Faktor risiko mask acne pada mahasiswa Fakultas Kedokteran Universitas Udayana angkatan 2019-2021 antara lain jenis kulit (p = 0,025), kondisi kulit berminyak setelah menggunakan masker (p<0,001), dan memiliki riwayat acne vulgaris akibat sinar matahari (p = 0,002).
Simpulan: Sekitar setengah dari jumlah mahasiswa Fakultas Kedokteran Universitas Udayana angkatan 2019-2021 mengalami mask acne dengan berbagai faktor risiko.
Polyphenol in olive oil: A promising adjuvant therapeutic agent in wound healing management and wound complication prevention
Authors: Sindhutomo Auddrey , Gede Wara Samsarga  , Astrinita Lestari Suyata  , Shita Diwyani Sudarsa
Published: November 2023

Wound is one of the most common findings in medical problems. Tissue repairment would return tissue integrity normally in morphology and function, but in certain cases, tissue repairment could be disrupted or uncontrolled. Disrupted tissue repair by infection agents, inadequate treatment, or other risk factors would lead to complications such as ulcers, gangrene, tissue death, or hypertrophic scar. These complications could lead to physical, mental, social, aesthetic, and financial burdens. Olive oil is a substance extracted from whole olive fruits widely used in the culinary world. Olive oil in skin treatment has been used since ancient times, and current research has developed in olive oil as an adjuvant treatment. Several researches have resulted in a positive result for olive oil as a promising agent for wound treatment to emulate tissue regeneration and prevent wound complications. According to several studies, flavonoids, oleuropein, phenolic acids, phenolic alcohols, lignans, and other compounds contribute as antioxidant and anti-inflammatory compounds. Certain substances in olive oil contribute as a cell protector, antimicrobial, and anticarcinogenic, which are important aspects of wound management, tissue recovery and complication prevention. These substances are found in eliminating oxidative species, lowering inflammatory responses, and inducing protein synthesis in tissue regeneration.
24-year-old obese woman with dilated cardiomyopathy: a case report of obese cardiomyopathy
Authors: Wikananda Gede Dehandra Dipastraya , Gumilang Putu Gupta Arya , Suwirya Agung Pradnyana
Published: November 2023

Background: Dilated cardiomyopathy is a disease characterized by enlargement of the heart ventricles with impaired left ventricular or biventricular systolic function. Obesity is a risk factor for changes in the structure and function of the heart, known as obese cardiomyopathy. The purpose of writing this case report is to holistically discuss obesity as a risk factor for dilated cardiomyopathy based on a literature review.
Case presentation: A 24-year-old woman complained of shortness of breath 2 months ago, appeared during activities and while she slept at night, and improved when sitting and resting. Other complaints are palpitations, swollen feet, nausea, and vomiting. Childhood history of obesity. Blood pressure 160/95 mmHg, respiratory rate 22 times/minute, and body mass index 33.8 kg/m2 (obesity II). The jugular venous pressure is increased. Auscultation revealed a systolic murmur at ICS 4 grade 3/6 and pulmonary crackles, with pitting edema in the legs. Electrocardiography revealed sinus tachycardia. Laboratory tests showed high triglycerides and total cholesterol, and other laboratories were within normal limits. Echocardiographic examination showed decreased left ventricular systolic function, severe left ventricular dilatation, and an ejection fraction of 27.9%. No significant lesions were found during the angiographic examination. A magnetic resonance imaging examination revealed non-ischemic cardiomyopathy, moderate left ventricular dysfunction, and severe right ventricular dysfunction. Patients were given heart failure therapy according to guidelines. On routine control, the patient's condition was stable.
Conclusion: Obesity is believed to be a risk factor for dilated cardiomyopathy through an increased hemodynamic load, neurohormonal dysregulation, inflammation, and lipotoxicity. Modalities such as the electrocardiogram, echocardiography, and magnetic resonance imaging can support the results of examinations for diagnosing dilated cardiomyopathy due to obesity. The management of obese cardiomyopathy involves changing lifestyles and administering drugs according to the clinical manifestations of heart failure.
A full-term infant with large patent ductus arteriosus successfully closed with oral ibuprofen: a case report
Authors: Christian Hans , Gunawijaya Eka , Limantara Veronica Lily , Limantara Ancelia , Gerdyman Joseph
Published: November 2023

Background: Ductus arteriosus is a vascular shunt between the aorta and pulmonary artery. Within the first 24-48 hours of life, the ductus usually closes. Failure of closure is called patent ductus arteriosus (PDA). Timing for treatment is crucial. Early treatment can decrease the need for drugs or surgery, but it can cause more adverse events, such as brain hemorrhage, bowel perforation and renal dysfunction. On the other hand, late treatment can cause complications such as pulmonary hemorrhage, necrotizing enterocolitis and can render drugs to be less effective.
Case Presentation: The patient was a 2 hours old male, 39 weeks, Apgar 7/8, 3100 grams, referred to the cardiology team because of tachypnea and peripheral cyanosis.  Initial echocardiographic showed large patent ductus arteriosus, coarctation aorta, patent foramen ovale and moderate tricuspid regurgitation. The patient was given 60mg of oral ibuprofen for the first day and 30mg of oral ibuprofen for the second and third days. In addition, the patient was given 2mg of furosemide, 2.5mg of spironolactone and 12.5mcg of digoxin twice daily to prevent heart failure. Echocardiographic evaluation after three days showed closure of large patent ductus arteriosus, no mild preductal coarctation aorta remains, trivial tricuspid and patent foramen ovale. No side effects were observed.
Conclusion: This case showed successful early treatment of large PDA in full-term infants with a double dose of oral ibuprofen. Adverse events were not found. As a result, Ibuprofen should be considered as an early treatment for PDA in full-term infants.
Candida auris as a pathogen that can cause emerging infectious disease: a literature review
Authors: Arthisari Ni Nyoman Nami , Budayanti Ni Nyoman Sri , Tarini Ni Made Adi
Published: November 2023

Candida auris is a fungal pathogen that can cause emerging infectious disease and infections related to health services (healthcare-associated infections) and threaten global health. It is one of the causes of candidemia, which has been connected to outbreaks and high mortality rates in medical facilities all over the world. Hospitalized patients who are critically ill, primarily in intensive care unit settings, account for the majority of reported infections. C. auris can be multi-resistant to various antifungal classes commonly used to treat other Candida infections. Invasive infection due to C. auris causes high mortality and morbidity rates. C. auris easily survives long enough in the surrounding environment to cause the rapid spread of outbreaks in health facilities. The critical need for novel, candidate antifungal medicines for C. auris therapies is driven by the pathogenicity, drug resistance, and widespread distribution of C. auris. In limiting the spread of C. auris, prompt investigations and aggressive interventions are required. These include alerting public health agencies, implementing contact precautions, thoroughly cleaning and disinfecting the environment, performing infection control assessments, tracing and screening contacts for colonization, reviewing the history of microbiology tests, and conducting prospective surveillance for cases at labs. C. auris poses a unique challenge in clinical settings due to its identification challenges, multidrug resistance traits, evolution of virulence factors, associated high patient fatality rates, and long-term survival on surfaces in the environment. This study aims to understand the epidemiology, clinical manifestations, characteristics, virulence factors, methods of identification, therapy and prevention control of infection by C. auris.
Bacterial patterns and antibiotic susceptibility among neonatal sepsis in Prof. Dr. I.G.N.G. Ngoerah Hospital, Bali, Indonesia
Authors: Jaya I Gusti Amanda , Gustawan I Wayan , Sukmawati Made , Fatmawati Ni Nengah Dwi
Published: November 2023

Background: Neonatal sepsis has the main cause of mortality and morbidity in neonates worldwide; the most frequent cause is bacteria. This study examined the bacterial patterns and antibiotic susceptibility in neonatal sepsis at Prof Ngoerah Hospital, Bali.
Methods: This observational, descriptive study was conducted in Prof Ngoerah Hospital, Bali, Indonesia involving neonatal sepsis confirmed with blood culture. Data on antibiotic susceptibility and bacterial patterns were collected retrospectively from the registry of neonates patients with neonatal sepsis from January 2021 to August 2022.
Results: The predominance of gram-negative bacteria was Acinetobacter baumannii (29.17%), Klebsiella pneumonia (10.42%), and the predominance of gram-positive bacteria was Staphylococcus haemolyticus (14.58%), Staphylococcus epidermidis (8.35%). The susceptibility was Gentamicin (57.29%), Ciprofloxacin (56.84%), Levofloxacin (55.21%), Trimethoprim/sulfamethoxazole (54.17%), Amikacin (50%), Meropenem (39.58%), Ampicilin/sulbactam (34.38%), Cefepim (32.29%), Piperacillin/Tazobactam (28.13%), Cefoperazone sulbactam (25%), Tigecycline (25%), Ceftriaxone (23.96%), and Vancomycin (22.92%).
Conclusion: Gram-negative bacteria were a common infection. This study suggests that the reconsideration of gentamicin still can be an option as an empirical antibiotic, but ampicillin has low sensitivity; another broad-spectrum antibiotic with better sensitivity is another option due to its significantly higher susceptibility.
The pentalogy of cantrell in limited resources: A case report
Authors: Maharini Kadek , Eka Gunawijaya  , Yantie Ni Putu Veny Kartika , Kardana I Made , Sudarma Wayan
Published: November 2023

Background: Pentalogy of Cantrell (PC) is a rare anomaly, and the incidence varies from 5.5 to 7.9 per million live births. The components are defined as a defect of the lower sternum, a midline supraumbilical thoracoabdominal wall defect, a deficiency of the diaphragmatic pericardium, a deficiency of the anterior diaphragm, and congenital cardiac anomalies. The pathognomonic characteristic of this syndrome is the coexistence of omphalocele and ectopia cordis. Diagnosis is possible by antenatal or physical examination, and other tests should be performed to detect other anomalies, including the heart's anomaly. Surgical treatment is complex, and various operative techniques often require a staged approach. The mortality rate is quite high, with a survival rate of less than 5%.
Case presentation: Two-day-old male infant was complained that his heart had been outside his chest wall since birth without covering by skin or sternum. He was born on aterm through section cesarean with a vigorous baby condition. Section cesarean was chosen because his mother has Human Immunodeficiency Virus (HIV)—no family history with similar symptoms. While pregnant, the mother regularly checks with the midwife and fetal ultrasonography only once during the third trimester but did not find the defect, no history of drug abuse, teratogen exposure, smoking, alcohol, or consanguinity. The midline defect extended from the lower part of the sternum completely. Echocardiography found defects such as classic Tetralogy of Fallot, mild atrial regurgitation, mild mitral regurgitation, mild tricuspid regurgitation, and suspect mass at left atrium (LA). The patients underwent surgery by covering the heart with a silo bag. Three days after the procedure, the patient's condition worsened and death because of the sepsis.
Conclusion: Prenatal diagnosis is important in guiding the surgical team to estimate the prognosis and reduce a postnatal management strategy. Early management can provide the basic care necessary to keep the patients until definitive management can be provided.
Association between T2DM with high resting heart rate and abnormal heart rate recovery within one minute after treadmill exercise test in CHD patients
Authors: Putra I Gede Bagus Gita Pranata , Kusuma Ida Bagus Budha Dharma , Armerinayanti Ni Wayan , Bagiari Ketut Erna , Wulandari Eka Sriayu
Published: November 2023

Background: Diabetes mellitus and coronary heart disease are chronic diseases that are very closely related. It has long been known that diabetes mellitus is a significant risk factor for coronary heart disease. The incidence of diabetes mellitus is increasing, according to data taken from the PERKENI consensus, WHO predicts an increase in the number of people with DM in Indonesia from 8.4 million in 2000 to around 21.3 million in 2030. The purpose of this study was to determine whether diabetes mellitus is related to cardiovascular autonomic neuropathy.
Methods: This research method is helpful to know that diabetes mellitus is directly related to cardiovascular autonomic neuropathy so that it will affect a person's hemodynamic quality functionally. In addition, to functionally affecting a person's hemodynamic capacity, determining that a patient with cardiovascular autonomic neuropathy is determined from the high resting heart rate and abnormal recovery heart rate variables after the treadmill exercise test, we can provide information and education to patients regarding the importance of a cardiac rehabilitation program in patients with coronary heart disease.
Results: A total of 45 people according to the calculation of the number of samples by type, male sex numbered 30 and female numbered 15 people. The number of patients who experienced impaired recovery of the 1-minute heart rate in this study was 25 people (55.5%) with the majority being male. And the number of sufferers who experience high heart rates at rest is 22 people (48.9%). In a bivariate analysis, patients with type 2 diabetes mellitus and without type 2 diabetes mellitus significantly worsened recovery heart rate (P value <0.05).
Conclusion: There is a significant relationship between diabetes mellitus on high resting heart rate and diabetes mellitus on poor heart rate recovery in 1 minute in patients with coronary heart disease.
Case report: corticosteroid as an alternative therapy for Kawasaki disease
Authors: Izawati Elok , Sandhi Parwata  , Maharani Pande Tiara
Published: November 2023

Background: Kawasaki disease is an acute febrile illness with systemic vasculitis and predominantly causes acquired heart disease. The etiology is still unknown, and there is no specific diagnostic test. The diagnosis was made using clinical criteria, laboratory and echocardiographic findings.  It is characterized by fever, bilateral non-exudative conjunctivitis, erythema of lips and oral mucosa, rash, cervical lymphadenopathy, edema and erythema of the hand and foot. The initial treatment for both complete and incomplete Kawasaki disease is a single high dose of intravenous immunoglobulin (IVIG) and aspirin. The place of corticosteroids in the initial therapy is still controversial.
Case Description: A 3-year-old boy presented with a 7-day history of high fever and not relieved by antipyretic, which was followed by a maculopapular rash on his trunk and extremities, vomiting, reduced appetite, red on her lips and eyes who aspirin, IVIG and corticosteroid treated as initial therapy. He showed clinical improvement and did not have cardiovascular complications.
Conclusion: We report a case of Kawasaki disease in a 3-year-old boy. This case highlighted that adding corticosteroids to IVIG and aspirin as initial therapy might improve outcomes in Kawasaki disease and could be selected as a treatment modality to treat Kawasaki disease.
Penggunaan klonidin sebagai terapi shivering pasca anestesi spinal: sebuah tinjauan sistematis
Authors: Arthana I Nyoman Dwi Ari
Published: November 2023

Background: Shivering can increase oxygen use, the risk of hypoxemia, and post-operative sequelae. The many properties of clonidine make this medication versatile enough to be employed not just to avoid shivering, but also to treat additional spinal anesthesia adverse effects.
Methods: Researchers combed the PubMed database for randomized clinical trials (RCTs) conducted between 2012 and 2022. Each study must be accessible and written in English. Individuals older than 18 who received spinal anesthesia operations.
Results: A total of 41 article abstracts and 12 full-length studies were evaluated, and seven papers met the inclusion criteria. The studied clinical outcome was the frequency of post-spinal anesthesia shivering. The majority of prior investigations found no significant difference in the shivering impact between the clonidine and midazolam groups. Shivering was much less common after tramadol treatment than after clonidine administration. Dexmedetomidine is known to be more effective than clonidine in controlling post-spinal blockade shivering.
Conclusion: Clonidine is beneficial in lowering the occurrence of post-spinal anesthesia shivering.
 
Latar Belakang: Shivering dapat meningkatkan konsumsi oksigen, meningkatkan risiko hipoksemia, dan meningkatkan komplikasi setelah operasi. Berbagai efek klonidin membuat agen ini cukup potensial untuk digunakan tidak hanya sebagai pencegahan shivering tetapi juga untuk mengatasi efek samping lain dari anestesi spinal.
Metode: Peneliti mencari database PubMed untuk uji coba terkontrol acak/randomized clinical trial (RCT) dalam periode 2012-2022. Setiap studi harus dalam bahasa Inggris dan dapat diakses untuk full review. Subjek berusia >18 tahun yang menjalani prosedur anestesi spinal.
Hasil: Total 41 abstrak artikel yang ditelaah, 12 studi full paper ditelaah dan 7 studi yang memenuhi kriteria inklusi. Keluaran klinis yang dievaluasi adalah kejadian shivering pasca anestesi spinal. Hasil sebagian besar studi sebelumnya menunjukkan bahwa tidak terdapat perbedaan bermakna efek shivering pada kelompok klonidin dan midazolam. Insiden shivering pasca pemberian tramadol secara bermakna lebih rendah dibandingkan kelompok klonidin. Pemberian dexmedetomidine diketahui lebih efisien dibandingkan klonidin untuk mengontrol post spinal blockade shivering
Kesimpulan: Klonidin efektif mengurangi kejadian shivering pasca anestesi spinal.
Management of blowout fracture with iliac bone graft
Authors: Pemayun Cokorda Agung Dalem , Yuliawati Putu , Utari Ni Made Laksmi , Djelantik AAA Sukartini , Hamid Agus Roy Rusly Hariantana
Published: November 2023

Introduction: Blowout fracture is a traumatic deformity of the orbital wall and the repair is indicated when enophthalmos is troublesome to the patient, or when diplopia interferes patient’s activities. Iliac bone has been reported in the immediate and secondary repair of orbital wall deformities following blowout fracture. This case is to report blowout fracture management using iliac bone graft.
Case Illustration: A 35 years old man complains pain on his left eye when moving his eye and diplopia in upgazed since 4 months after fell down from stairs. Eye position is orthophoria, visual acuity 6/6 on both eye, anterior and posterior segments are normal, restricted movement to superior on left eye, Hertel exophthalmometry examination on right eye 15 mm and left eye 10 mm (base 90). On CT-scan examination, it was found that an orbital floor fracture was characterized by herniation of the orbital tissue. The patient was diagnosed with left eye enophthalmos, suspect inferior rectus muscle and adnexal entrapment and neglected blow out fracture. LE Repair Orbital Floor Fracture, Release Muscle Rectus Inferior, Exploration (join op with Plastic Reconstructive and Aesthetic Surgery Department) is done to this patient.
Conclusion: Iliac bone graft can be used as an alternative in orbital floor reconstruction, since it easy to harvest, low risk to rejected or extruded and can be used in large defect. Optimal outcome of blowout fracture repair can be achieved if the surgical management is done before two weeks after the incidence.
Correlation between nutritional status and side effects of covid-19 vaccination in students of Senior High School 1 Namorambe, Sumatra, Indonesia
Authors: Lavia Safarna , Lubis Inke Nadia Diniyanti , Daulay Rini Savitri
Published: November 2023

Introduction: The global pandemic caused by the Coronavirus Disease 2019 (COVID-19) is currently causing havoc in various sectors of global life, such as public health, the economy, and life. Vaccines are biological agents that can provide active protection against specific infectious diseases. The side effects that can be caused by the COVID-19 vaccine are very wide, and the most common side effects are pain, fatigue, and headaches. This study aimed to determine the relationship between the occurrence of side effects of the COVID-19 vaccine and the nutritional status of Senior High School 1 Namorambe students, Deli Serdang Regency, North Sumatera Province.
Method: This research is an observational study with a cross-sectional study design. The population in this study were all Senior High School 1 Namorambe students who were participants in the COVID-19 vaccination, namely 657 students, the sample in the study was 196 students.
Result: The results of the study, namely the most common side effects experienced by research subjects were colds (15.8%), headaches (15.1%), nasal congestion (10.3%), coughs (9.8%), and fever (8.0%). The results of the bivariate analysis found that there was no significant relationship between gender, age group, and nutritional status with the incidence of COVID-19 vaccine side effects (H0, H28, and H60) in Senior High School 1 Namorambe students (p-value >0.05).
Conclusion: It is necessary to carry out further research on the relationship between nutritional status and the incidence of side effects of the COVID-19 vaccine in adolescents using a larger and heterogeneous population to reduce bias factors.
Hubungan stadium klinis awal dan lanjut dengan kejadian depresi pada penderita Karsinoma Nasofaring (KNF) sebelum terapi di Poliklinik THT – KL RSUP Prof. Dr. IGNG Ngoerah, Bali, Indonesia
Authors: Sudana Ketut Wahyudiana , Suanda I Ketut , Sutanegara Sari Wulan Dwi
Published: November 2023

Background: Nasopharyngeal Carcinoma (NPC) is a tumor or malignancy that manifests in the nasopharynx, in the upper throat and back of the nose. When someone is diagnosed with cancer, many of them experience mental disorders, such as one example of depression. This study aimed to determine the relationship between early and advanced clinical stages with the incidence of depression in nasopharyngeal carcinoma patients before therapy.
Methods: An observational cross sectional comparative study design was conducted. Fifty-four research subjects were obtained with consecutive sampling techniques. The data obtained were analyzed descriptively, followed by the Chi-Square test and ended with the Logistic Regression test by SPSS version 26.0 for Windows.
Results: Based on bivariate analysis, three variables are significantly related to the level of depression in NPC patients, such as age, level of education and stage of cancer (p<0.05). Based on multivariate analysis using Logistic Regression, only one variable had a statistically significant relationship with the level of depression in NPC patients, namely the cancer stadium variable (p=0.001).
Conclusion: These findings suggest a significant relationship between the stage of cancer and the level of depression in NPC patients.
 
Latar Belakang: Karsinoma Nasofaring (KNF) adalah tumor atau keganasan yang bermanifestasi pada daerah nasofaring yaitu pada daerah atas tenggorokan dan belakang hidung. Ketika seseorang didiagnosa menderita kanker,banyak yang mengalami gangguan mental seperti salah satu contohnya depresi. Tujuan penelitian ini adalah untuk mengetahui hubungan stadium klinis awal dan lanjut dengan kejadian depresi pada pasien karsinoma nasofaring sebelum terapi.
Metode: observasional dengan rancangan cross sectional comparative study. Didapatkan 54 subjek penelitian dengan tehnik consecutive sampling. Data yang diperoleh dianalisis secara deskriptif, dilanjutkan dengan uji Chi-Square dan diakhiri uji Regresi Logistik menggunakan SPSS versi 26.0 untuk Windows.
Hasil: Berdasarkan analisis bivariat, terdapat tiga variabel yang berhubungan secara bermakna dengan tingkat deprersi pada pasien KNF yakni usia, tingkat pendidikan terakhir dan stadium kanker (p<0.05). Berdasarkan analisis multivariat dengan menggunakan Regresi Logistik hanya terdapat satu variabel yang secara statistik memiliki hubungan bermakna dengan tingkat depresi pada pasien KNF yaitu variabel stadium kanker (p=0.001).
Kesimpulan: Hasil penelitian ini menunjukkan bahwa terdapat hubungan yang bermakna antara stadium kanker dengan tingkat depresi pada pasien KNF.
Siklopiroks olamin topikal pada onikomikosis rekalsitran yang disebabkan Aspergillus spp.: sebuah laporan kasus
Authors: Mahariski Pande Agung , Karna Ni Luh Putu Ratih Vibriyanti , Winaya Ketut Kwartantaya , Wirya Andrew Yoshihiro
Published: November 2023

Background: Aspergillus spp., Scopulariopsis spp., Alternaria spp., Acremonium spp. and Fusarium spp. is reported to be responsible as the causative agent of infection in 2-25% of all cases of onychomycosis. The resistance of three types of azole (triazole) antifungals has increased in cases of infection due to Aspergillus spp. This case report discusses combining ciclopirox olamine and fluconazole in recalcitrant onychomycosis due to Aspergillus spp. as an alternative therapy.
Case: A 26-year-old woman complained of yellow fingernails 1 year ago. Solitary geographic hyperpigmented macule, brownish yellow onychodyschromia, onycholysis and subungual debris were observed on the fourth digit of the left manus. On examination of 20% potassium hydroxide, long hyphae, and saboraoud dextrose agar (SDA) culture identified Aspergillus spp. Previous treatment was itraconazole 4 pulses and fluconazole 150 mg/week for 3 months showed no improvement. Ciclopirox olamine for 4 months combined with fluconazole 150 mg/week showed healthy nail matrix growth and negative fungal element on a 20% potassium hydroxide examination after 8 weeks of treatment.
Conclusion: Recalcitrant onychomycosis can occur due to resistance to azole antifungals. Administration of topical azoles and ciclopirox combination therapy showed clinical and immunological improvements.
 
Latar belakang: Aspergillus spp., Scopulariopsis spp., Alternaria spp., Acremonium spp. dan Fusarium spp. merupakan kapang nondermatofita tersering yang dilaporkan bertanggung jawab sebagai agen penyebab infeksi pada 2-25% dari semua kasus onikomikosis. Saat ini resistensi tiga jenis antijamur golongan azol (triazol) meningkat pada kasus infeksi akibat Aspergillus spp. dan terapi inadekuat dapat menyebabkan resistensi dan rekurensi. Laporan kasus ini membahas penggunaan kombinasi siklopiroks olamin dan flukonazol pada onikomikosis rekalsitran karena Aspergilus spp. sebagai terapi alternatif.
Kasus: Seorang perempuan 26 tahun mengeluh kuku jari tangan menguning sejak 1 tahun lalu. Pada digiti IV manus sinistra didapatkan makula hiperpigmentasi soliter bentuk geografika, onikodiskromia kuning kecoklatan, onikolisis dan subungual debris dengan pemeriksaan kalium hidroksida (KOH) 20% ditemukan hifa-hifa panjang dan kultur saboraoud dextrose agar (SDA) teridentifikasi Aspergillus spp. Riwayat terapi sebelumnya dengan itrakonazol 4 denyut dan flukonazol 150mg/minggu selama 3 bulan tidak menunjukkan perbaikan. Siklopiroks olamin selama 4 bulan dengan melanjutkan flukonazol diberikan dan menunjukkan perbaikan matriks kuku normal dan KOH negatif setelah 8 minggu perawatan.
Simpulan: Onikomikosis rekalsitran dapat terjadi karena adanya resistensi terhadap antijamur golongan azol. Pemberian terapi kombinasi golongan azol dan siklopiroks topikal menunjukkan perbaikan klinis serta imunologis.
The association between achieve of full feeding with mortality in children at sanglah hospital
Authors: Sihombing Rina Margareth , Sidiartha I Gusti Lanang , I Gusti Ayu Eka Pratiwi
Published: November 2023

Background: For pediatric patients who are hospitalized, full feeding nutritional needs is not only to improve BMI but also very useful for accelerating the healing process, shortening the treatment period, reducing complications, reducing morbidity and mortality, and preventing malnutrition due to treatment or medical action. This study aimed to describe the association between the achievement of full feeding with mortality in children.
Method: The retrospective study was conducted in Pediatric Ward at Sanglah General Hospital, Denpasar Bali period January to December 2021. The inclusion criteria in this study were all pediatric patients who were hospitalized at pediatric wards Sanglah Hospital Denpasar. Inclusion criteria were children aged 1 month-18 years old. Samples were taken by total sampling. Quantitative variables were tested using variables that scale categorical data will be displayed in the form of absolute numbers and percent. The results of the descriptive analysis are presented using a chi-square test used to analyze all indirect variables (depending on whether the assumptions were met). The results of multivariate analysis were  with logistic regression. The results were considered statistically significant at p < 0.05.
Result: Total 258 subjects who met the inclusion criteria. Multivariate analysis with logistic regression shows full feeding (Exp B 0.24; 95% CI 0.032-0.27; P 0.006), nutritional status (Exp B 0.23; 95% CI 0.31-1.55; P 0,004) was statistically significant for mortality.
Conclusion: Full feeding and nutritional status were associated with an increase in child mortality.
Perbandingan penanganan operatif dengan non operatif pada tatalaksana dislokasi bahu anterior terhadap rekurensi: systematic review
Authors: Ardhaswari Made Sabrina Prativa Prasaditya , Astawa Putu , Asmara Anak Agung Gde Yuda
Published: November 2023

Background: Shoulder dislocations are very prone to recurrent shoulder dislocations, the best treatment for reducing recurrence is controversial in several studies. Thus, the aim of this study was to compare operative and nonoperative management of anterior dislocation of the shoulder against recurrence.
Method: The literature search used PubMed and Google Scholar databases and met the inclusion criteria from 2010-2020 regarding the comparison of operative and non-operative treatment on anterior shoulder dislocation on recurrence. This systematic review was prepared by using the PRISMA protocol (Preferred Reporting Items for Systematic Reviews and Meta-Analyzes).
Result: Five studies were reviewed with a total sample size of 635 samples. Three studies stated that the recurrence rate for operative was 10-13% and non-operative was 41-71% and there was a significant difference. Meanwhile, two other studies stated that there was no significant difference between operative and non-operative on recurrence rates.
Conclusion: Studies suggest that non-operative management recurs more frequently in shoulder dislocation than operative management.
 
Pendahuluan: Dislokasi bahu sangat rentan untuk terjadi dislokasi bahu berulang (recurrent). Hingga saat ini, penanganan yang terbaik dalam menurunkan rekurensi masih bersifat kontroversial dalam beberapa studi. Untuk itu, tujuan dari studi ini adalah untuk membandingan penanganan operatif dengan non operatif pada tatalaksana dislokasi bahu anterior terhadap rekurensi
Metode: Pencarian literatur menggunakan database PubMed dan Google Scholar, serta memenuhi kriteria inklusi dari tahun 2010-2020 mengenai perbandingan operatif dan non operatif pada dislokasi bahu anterior terhadap rekurensi. Penulian systematic review ini disusun menggunakan protocol PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). 
Hasil: Lima studi yang diulas dengan jumlah sampel sebanyak 635 sampel. Tiga studi menyebutkan recurrence rate pada operatif sebesar 10-13% dan non operatif sebesar 41-71% dan terjadi perbedaan yang signifikan. Sedangkan, dua studi lainnya menyebutkan recurrence rate pada operatif dan non operatif menunjukkan tidak ada perbedaan yang signifikan.
Kesimpulan: Keseluruhan studi menyebutkan bahwa penanganan non operatif lebih sering mengalami rekurensi pada dislokasi bahu dibandingkan dengan penanganan operatif.
Materials come around and go around: Adapting to nature’s circularity
Authors: Schüpfer Dominique , Wagner-Wenz Ronja , Hendrich Katharina , Weidenkaff Anke
Published: November 2023

The present multiple crises, such as climate change, war, and the recent pandemic, highlight the need for a stable and secure resource supply chain to overcome resource scarcity and shortages in manufacturing as well as in goods for everyday needs. Today’s linear production chains and waste management systems contribute to disruptions in resource availability as well as to greenhouse gas emissions. The concept of a holistic circular economy, inspired by natural processes, could help to mitigate these challenges. With a primary goal of maintaining resources, as much as possible, in “closed loops,” the following three challenges should be addressed: (1) Dissipation of resources, (2) Irreversibility of some processes, and (3) Logistical, technological, and information. These challenges can be addressed, in part, by implementing computational technology and cascading mechanical and chemical recycling processes in waste and resource management. This article emphasizes the interconnection between resource scarcity and pollution and climate change, and proposes a holistic circular economy as an important contribution to addressing this challenge. This holistic circular economy can be inspired, in part, by nature’s self-healing, self-transformation, and self-disintegration capabilities. Another crucial part is a comprehensive understanding of the limited resources of the planet and the impact on the planet of using up these resources and, thereby, leading to a shift toward sustainable material use and waste management. The transition to a circular economy requires changes at many levels, encompassing materials research, technical engineering, industrial implementation, and societal adaptation. In both product and process development, regardless of the technological readiness level, life-cycle analyses must be performed that consider the impact on the planet. With the help of a “product passport,” a suitable legal framework can be created and implemented. Radical changes in the way we carry out research into technologically relevant materials can pave the way to a holistic circular economy.
Refining Methodological Reflection: Exploring the Interviewing Experience of Oocyte Donors
Authors: Gramatchikova Natalya B. , Polyakova Irina G.
Published: November 2023

The article reflects on the collaborative experience between a practicing psychologist actively involved in the oocyte donation protocol (participating in guide development, conducting interviews, and drawing conclusions for the clinic) and a philologist who interprets the interview transcripts using narrative and communicative situation analyses. The article begins by describing the interviewing process, the structure of the oocyte-donor guide, and the profile of a “stable donor,” drawing from Russian-language materials. Through narrative analysis of 21 transcripts, the roles of the interviewer and informant at each stage of the interview process are identified, along with their contributions to the discussion and testing of the communicative situation. The paper investigates both the instances of cooperation and discrepancies observed among the participants as they strive to construct a credible and value-consistent autobiographical narrative that comprehensively encompasses their donation experience. The article analyzes both explicit and hidden narrative motives placed by informants in a conversation unfolding from the respondent’s past into a projected future. The authors aim to situate this experience within a broader personal value context, which includes compensatory aspects related to the pressing concerns of potential donors.
A Jaynes-Cummings Model with a Landau-Zener Interaction
Authors: Das Tapas , Dasgupta Ananda
Published: November 2023

The Jaynes-Cummings Model has been a standard paradigm for light-matter interaction for a few decades. The Lie algebraic properties of the model permits us to solve for the time evolution of a coupled radiation-matter system. In this work we study the model with linear time dependence
and show that it is analytically solvable. We use our results to calculate the Mandel Q-parameter which shows how nonclassical the resulting radiation state is.
Molecular analysis of Karawang local soybean genotypes with national superior varieties based on SSR analysis
Authors: Komariah A. , Wahyuni D.S. , Ramdhani  , Ria E. R. , Noertjahyani
Published: November 2023

Abstract The aim of this study was to analyze the similarities between the Karawang local superior varieties and several national superior varieties based on chromosome analysis or allele size. Analysis were carried out in the laboratory of the Biogen Research Institute in 2021. There were 9 genotypes analyzed, consisting of 8 national superior varieties, namely NS Karawang, Argomulyo, Grobogan, Anjasmoro, Devon-1, Detap-1, Dena-1 and Dena-2 and 1 Karawang local soybean genotypes. The results of the analysis show that Karawang local soybean has a difference with the national superior variety. The similarity of local soybeans from Karawang to NS Karawang with varieties Agromulyo and Grobogan is 68%, with soybean varieties Anjasmoro and Devon-1 is 71%, while with soybeans Detap-1, Dena-1 and Dena-2 is 76%.
Approach to food processing in the main messages of food-based dietary guidelines: A qualitative analysis
Authors: Gris Cintia Cassia Tonieto , Martinelli Suellen Secchi , Fabri Rafaela Karen , Cavalli Suzi Barletto
Published: November 2023

ABSTRACT Objective: Analyze the content of the main messages of the world food guides, identifying the approach regarding the food processing level. Methods: This qualitative exploratory study was conducted through documentary research based on analyzing the main messages of 96 consumption guides selected from the database provided by the Food and Agriculture Organization of the United Nations. The unit of analysis consisted of segments of the main messages whose content was scrutinized using the document analysis technique. Recommendations that referred to food processing were identified after repeated readings. Data were extracted according to the developed protocol, including terms used, consumption guidance, scope of approach, and complementary information (definition, justification, exemplification, and advice on the recommended consumption amount). Results: We identified 21 Food Guides (21.88%) with recommendations related to the food processing level in their main messages, primarily published after 2012 (76.19%). The analyzed guides used terms “highly processed”, “ultra-processed”, “processed”, “minimally processed”, and “non-processed”. Guidelines regarding limiting consumption were primarily used by the guides, and few specified the related food. The messages did not define the terms used. When identified, the justifications were of a nutritional or health nature. Conclusion: We observed a lack of agreement and standardization concerning the terms used, the guidelines for consumption, and the scope of the identified recommendations, with little or no additional information to explain or justify the approach adopted regarding the food processing level.