bluuebunny/crossref_metadata_2025 huggingface dataset:
Energy-Neutral Data Collection Rate Control for IoT Animal Behavior Monitors
Authors: Wilhelm Jay , Blackshire Sheldon , Lanzone Michael
Published: November 2017

Energy-neutral operation (ENO) is a major concern for Internet of things (IoT) sensor systems. Animals can be tagged with IoT sensors to monitor their movement and behavior. These sensors wirelessly upload collected data and can receive parameters to change their operation. Typically, the behavior monitors are powered by a battery where the system relies upon harvesting solar radiation for sustainable operation. Solar panels typically are used as the harvesting mechanism and can have a level of uncertainty regarding consistent energy delivery due to factors such as adverse weather, foliage, time of day, and individual animal behavior. The variability of available energy inevitably creates a trade-off in the rate at which data can be collected with respect to incoming and stored energy. The objective of this research was to investigate and simulate methods and parameters that can control the data collection rate of an IoT behavior monitor to achieve sustained operation with unknown and random energy harvesting. Analysis and development of a control system were performed by creating a software model of energy consumption and then simulating using different initial conditions and random energy harvesting rates for evaluation. The contribution of this effort was the exploration into the usage of a discrete-time gain scheduled Proportional–Integral–Derivative (PID) that was tuned to a specific device configuration, using battery state of charge as an input, and found to maintain a battery level set-point, reject small solar harvesting energy disturbances, and maintain a consistent data collection rate throughout the day.
Acyclic Arylamine-Based Ionophores as Potentiometric Sensors for Zn2+ and Ni2+ Ions
Authors: Kaur Harpreet , Chhibber Manmohan , Mittal Susheel
Published: November 2017

Two receptor molecules N-(2-nitrophenyl)benzene-1,2-diamine (DPA) and N,N-bis(2-nitrophenyl)benzene-1,2-diamine (TPA) are proposed as Zn2+ and Ni2+-selective electrodes, respectively. The two electrodes respond to Zn2+ and Ni2+ ions with the detection limits of 1.3 × 10−6 M and 2.8 × 10−6 M, respectively. Both the electrodes have a life time of four months and respond within 15 s and 20 s, respectively, for Zn2+ and Ni2+ over a wide pH range (3–9). The electrodes show very good selectivity towards the primary ions in presence of some alkali, alkaline earth, and transition metal ions.
A Mixed Methods Study on the Effect of Flipping the Undergraduate Medical Classroom
Authors: Burak Kelly , Raman Maitreyi , Paget Michael , Busche Kevin , Coderre Sylvain , McLaughlin Kevin
Published: November 2017

The flipped classroom model is increasingly being adopted in healthcare education, despite the fact that recent systematic reviews in the nursing and medical education literature suggest that this method of instructional design is not inherently better or worse than the traditional classroom. In this study, we used a sequential, explanatory mixed methods design to assess the impact of flipping the hepatology classroom for preclinical medical students. Compared to students in the traditional classroom, students in the flipped classroom had significantly lower mean (SD) ratings of their learning experiences (3.48 (1.10) vs. 4.50 (0.72), p < 0.001, d = 1.10), but better performance on the hepatology content of the end-of-course examination (78.0% (11.7%) vs. 74.2 (15.1%), respectively, p < 0.01, d = 0.3). Based upon our qualitative data analyses, we propose that the flipped classroom induced a change in the learning process of students by requiring increased preparation for classroom learning and promoting greater learner autonomy, which resulted in better retention of learned material, but reduced enjoyment of the learning experience. This dissonance in outcomes is captured in the words of one flipped classroom student: “…I hated it while I was learning it, but boy did I remember it…”. Based upon our dissonant outcomes and the inconsistent findings in the literature, we feel that there is still equipoise regarding the effectiveness of the flipped classroom, and further studies are needed to describe ways of making the flipped classroom a more effective (±more enjoyable) learning experience.
Impact-Based Electromagnetic Energy Harvester with High Output Voltage under Low-Level Excitations
Authors: Luo Qian , He Xuefeng , Jiang Senlin , Wang Xingchang
Published: November 2017

To expand the applications of vibrational energy harvesters (VEHs) as power sources of wireless sensor nodes, it is of significance to improve the scavenging efficiency for the broadband, low-frequency, and low-level vibrational energy. The output voltages of electromagnetic vibrational energy harvesters (EMVEHs) are usually low, which complicates the power management circuit by an indispensable voltage boosting element. To this end, an impact-based non-resonant EMVEH mainly composed of an outer frame and an inner frame on rollers is proposed. Numerical simulations based on a mathematical model of the harvester are conducted to analyze the effects of structural parameters on the output performance. Under base excitation of 0.1 and 0.3 (where g is the gravitational acceleration, 1 g = 9.8 m · s − 2 ), the experimental maximum root mean square voltages of a harvester prototype across a resistor of 11 kΩ are as high as 7.6 and 16.5 V at 6.0 and 8.5 Hz, respectively, with the maximum output powers of 5.3 and 24.8 mW, or the power densities of 54.6 and 256 μW cm−3. By using a management circuit without a voltage boosting element, a wireless sensor node driven by the prototype can measure and transmit the temperature and humidity every 20 s under base excitation of 0.1 g at 5.4 Hz.
Experimental Studies of Phase Change and Microencapsulated Phase Change Materials in a Cold Storage/Transportation System with Solar Driven Cooling Cycle
Authors: Zheng Lin , Zhang Wei , Liang Fei , Lin Shuang , Jin Xiangyu
Published: November 2017

The paper presents the different properties of phase change material (PCM) and Microencapsulated phase change material (MEPCM) employed to cold storage/transportation system with a solar-driven cooling cycle. Differential Scanning Calorimeter (DSC) tests have been performed to analyze the materials enthalpy, melting temperature range, and temperature range of solidification. KD2 Pro is used to test the thermal conductivities of phase change materials slurry and the results were used to compare the materials heat transfer performance. The slurry flow characteristics of MEPCM slurry also have been tested. Furthermore, in order to analyze the improvement effect on stability, the stability of MEPCM slurry with different surfactants have been tested. The researches of the PCM and MEPCM thermal properties revealed a more prospective application for phase change materials in energy storage/transportation systems. The study aims to find the most suitable chilling medium to further optimize the design of the cold storage/transportation systems with solar driven cooling cycles.
Request Expectation Index Based Cache Replacement Algorithm for Streaming Content Delivery over ICN
Authors: Li Haipeng , Nakazato Hidenori , Ahmed Syed
Published: November 2017

Since the content delivery unit over Information-Centric Networking (ICN) has shifted from files to the segments of a file named chunks, solely either file-level or chunk-level request probability is insufficient for ICN cache management. In this paper, a Request Expectation Index (RXI) based cache replacement algorithm for streaming content delivery is proposed. In this algorithm, RXI is introduced to serve as a fine-grained and unified estimation criteria of possible future request probability for cached chunks. RXI is customized for streaming content delivery by adopting both file-level and chunk-level request probability and considering the dynamically varied request status at each route as well. Compared to prior work, the proposed algorithm evicts the chunk with the minimum expectation of future request to maintain a high cache utilization. Additionally, simulation results demonstrate that the RXI-based algorithm can remarkably enhance the streaming content delivery performance and can be deployed in complex network scenarios. The proposed results validate that, by taking fine-grained request probability and request status into consideration, the customized in-network caching algorithm can improve the ICN streaming content delivery performance by high cache utilization, fast content delivery, and lower network traffic.
Food Swamps Predict Obesity Rates Better Than Food Deserts in the United States
Authors: Cooksey-Stowers Kristen , Schwartz Marlene , Brownell Kelly
Published: November 2017

This paper investigates the effect of food environments, characterized as food swamps, on adult obesity rates. Food swamps have been described as areas with a high-density of establishments selling high-calorie fast food and junk food, relative to healthier food options. This study examines multiple ways of categorizing food environments as food swamps and food deserts, including alternate versions of the Retail Food Environment Index. We merged food outlet, sociodemographic and obesity data from the United States Department of Agriculture (USDA) Food Environment Atlas, the American Community Survey, and a commercial street reference dataset. We employed an instrumental variables (IV) strategy to correct for the endogeneity of food environments (i.e., that individuals self-select into neighborhoods and may consider food availability in their decision). Our results suggest that the presence of a food swamp is a stronger predictor of obesity rates than the absence of full-service grocery stores. We found, even after controlling for food desert effects, food swamps have a positive, statistically significant effect on adult obesity rates. All three food swamp measures indicated the same positive association, but reflected different magnitudes of the food swamp effect on rates of adult obesity (p values ranged from 0.00 to 0.16). Our adjustment for reverse causality, using an IV approach, revealed a stronger effect of food swamps than would have been obtained by naïve ordinary least squares (OLS) estimates. The food swamp effect was stronger in counties with greater income inequality (p < 0.05) and where residents are less mobile (p < 0.01). Based on these findings, local government policies such as zoning laws simultaneously restricting access to unhealthy food outlets and incentivizing healthy food retailers to locate in underserved neighborhoods warrant consideration as strategies to increase health equity.
Impending Doom: The Loss of Diversification before a Crisis
Authors: Yang Libin , Rea William , Rea Alethea
Published: November 2017

We present four methods of assessing the diversification potential within a stock market, and two of these are based on principal component analysis. They were applied to the Australian stock exchange for the years 2000 to 2014 and all show a consistent picture. The potential for diversification declined almost monotonically in the three years prior to the 2008 financial crisis, leaving investors poorly diversified at the onset of the Global Financial Crisis. On one of the four measures, the diversification potential declined even further in the 2011 European debt crisis and the American credit downgrade.
Integrated Pest Management of Coffee Berry Borer in Hawaii and Puerto Rico: Current Status and Prospects
Authors: Aristizábal Luis , Johnson Melissa , Shriner Suzanne , Hollingsworth Robert , Manoukis Nicholas , Myers Roxana , Bayman Paul , Arthurs Steven
Published: November 2017

The coffee berry borer (CBB), Hypothenemus hampei, is the most significant insect pest of coffee worldwide. Since CBB was detected in Puerto Rico in 2007 and Hawaii in 2010, coffee growers from these islands are facing increased costs, reduced coffee quality, and increased pest management challenges. Here, we outline the CBB situation, and summarize the findings of growers, researchers, and extension professionals working with CBB in Hawaii. Recommendations for the Integrated Pest Management (IPM) program for CBB in Hawaiian Islands and Puerto Rico include: (1) establish a CBB monitoring program, (2) synchronize applications of insecticides with peak flight activity of CBB especially during the early coffee season, (3) conduct efficient strip-picking as soon as possible after harvest and perform pre-harvest sanitation picks in CBB hotspots if needed, (4) establish protocols to prevent the escape of CBB from processing areas and when transporting berries during harvest, and (5) stump prune by blocks. Progress achieved includes the introduction of the mycoinsecticide Beauveria bassiana to coffee plantations, the coordination of area-wide CBB surveys, the establishment and augmentation of native beetle predators, and an observed reduction of CBB populations and increased coffee quality where IPM programs were established. However, CBB remains a challenge for coffee growers due to regional variability in CBB pressures, high costs, and labor issues, including a lack of training and awareness of CBB management practices among growers.
Morphological Transition in Diamond Thin-Films Induced by Boron in a Microwave Plasma Deposition Process
Authors: Baker Paul , Goodloe David , Vohra Yogesh
Published: November 2017

The purpose of this study is to understand the basic mechanisms responsible for the synthesis of nanostructured diamond films in a microwave plasma chemical vapor deposition (MPCVD) process and to identify plasma chemistry suitable for controlling the morphology and electrical properties of deposited films. The nanostructured diamond films were synthesized by MPCVD on Ti-6Al-4V alloy substrates using H2/CH4/N2 precursor gases and the plasma chemistry was monitored by the optical emission spectroscopy (OES). The synthesized thin-films were characterized by x-ray diffraction and scanning electron microscopy. The addition of B2H6 to the feedgas during MPCVD of diamond thin-films changes the crystal grain size from nanometer to micron scale. Nanostructured diamond films grown with H2/CH4/N2 gases demonstrate a broad (111) Bragg x-ray diffraction peak (Full-Width at Half-Maximum (FWHM) = 0.93° 2θ), indicating a small grain size, whereas scans show a definite sharpening of the diamond (111) peak (FWHM = 0.30° 2θ) with the addition of boron. OES showed a decrease in CN (carbon–nitrogen) radical in the plasma with B2H6 addition to the gas mixture. Our study indicates that CN radical plays a critical role in the synthesis of nanostructured diamond films and suppression of CN radical by boron-addition in the plasma causes a morphological transition to microcrystalline diamond.
The killer of Socrates: Coniine and Related Alkaloids in the Plant Kingdom
Authors: Hotti Hannu , Rischer Heiko
Published: November 2017

Coniine, a polyketide-derived alkaloid, is poisonous to humans and animals. It is a nicotinic acetylcholine receptor antagonist, which leads to inhibition of the nervous system, eventually causing death by suffocation in mammals. Coniine’s most famous victim is Socrates who was sentenced to death by poison chalice containing poison hemlock in 399 BC. In chemistry, coniine holds two historical records: It is the first alkaloid the chemical structure of which was established (in 1881), and that was chemically synthesized (in 1886). In plants, coniine and twelve closely related alkaloids are known from poison hemlock (Conium maculatum L.), and several Sarracenia and Aloe species. Recent work confirmed its biosynthetic polyketide origin. Biosynthesis commences by carbon backbone formation from butyryl-CoA and two malonyl-CoA building blocks catalyzed by polyketide synthase. A transamination reaction incorporates nitrogen from l-alanine and non-enzymatic cyclization leads to γ-coniceine, the first hemlock alkaloid in the pathway. Ultimately, reduction of γ-coniceine to coniine is facilitated by NADPH-dependent γ-coniceine reductase. Although coniine is notorious for its toxicity, there is no consensus on its ecological roles, especially in the carnivorous pitcher plants where it occurs. Lately there has been renewed interest in coniine’s medical uses particularly for pain relief without an addictive side effect.
Phospholipids of Animal and Marine Origin: Structure, Function, and Anti-Inflammatory Properties
Authors: Lordan Ronan , Tsoupras Alexandros , Zabetakis Ioannis
Published: November 2017

In this review paper, the latest literature on the functional properties of phospholipids in relation to inflammation and inflammation-related disorders has been critically appraised and evaluated. The paper is divided into three sections: Section 1 presents an overview of the relationship between structures and biological activities (pro-inflammatory or anti-inflammatory) of several phospholipids with respect to inflammation. Section 2 and Section 3 are dedicated to the structures, functions, compositions and anti-inflammatory properties of dietary phospholipids from animal and marine sources. Most of the dietary phospholipids of animal origin come from meat, egg and dairy products. To date, there is very limited work published on meat phospholipids, undoubtedly due to the negative perception that meat consumption is an unhealthy option because of its putative associations with several chronic diseases. These assumptions are addressed with respect to the phospholipid composition of meat products. Recent research trends indicate that dairy phospholipids possess anti-inflammatory properties, which has led to an increased interest into their molecular structures and reputed health benefits. Finally, the structural composition of phospholipids of marine origin is discussed. Extensive research has been published in relation to ω-3 polyunsaturated fatty acids (PUFAs) and inflammation, however this research has recently come under scrutiny and has proved to be unreliable and controversial in terms of the therapeutic effects of ω-3 PUFA, which are generally in the form of triglycerides and esters. Therefore, this review focuses on recent publications concerning marine phospholipids and their structural composition and related health benefits. Finally, the strong nutritional value of dietary phospholipids are highlighted with respect to marine and animal origin and avenues for future research are discussed.
The Effects of 4′-Esterified Resveratrol Derivatives on Calcium Dynamics in Breast Cancer Cells
Authors: Peterson Joshua , Doughty Hayden , Eells Austin , Johnson Trent , Hastings Jordan , Crowther Colton , Andrus Merritt , Kenealey Jason
Published: November 2017

Triple-negative breast cancer is a highly aggressive subtype of breast cancer. Frequently, breast cancer cells modulate their calcium signaling pathways to optimize growth. Unique calcium pathways in breast cancer cells could serve as a way to target tumorigenic cells without affecting normal tissue. Resveratrol has previously been shown to activate calcium signaling pathways. We use cell viability, single-cell calcium microscopy, and RT-PCR assays to determine the activity and mechanism of three different 4′-esterified resveratrol derivatives. We demonstrate that two of the derivatives reduce cell viability more effectively than resveratrol in MDA-MB-231 human breast cancer cells. The derivatives also activate similar pro-apoptotic calcium signaling pathways. In particular, the pivalated and butyrated resveratrol derivatives are intriguing putative chemotherapeutics because they are more effective at decreasing cell viability in vitro and inhibiting the plasma membrane Ca2+-ATPase, a protein that is often modulated in breast cancer.
Intratumoral Delivery of Doxorubicin on Folate-Conjugated Graphene Oxide by In-Situ Forming Thermo-Sensitive Hydrogel for Breast Cancer Therapy
Authors: Fong Yi , Chen Chih-Hao , Chen Jyh-Ping
Published: November 2017

By taking advantage of the pH-sensitive drug release property of graphene oxide (GO) after intracellular uptake, we prepared folic acid (FA)-conjugated GO (GOFA) for targeted delivery of the chemotherapeutic drug doxorubicin (DOX). GOFA-DOX was further encapsulated in an injectable in-situ forming thermo-sensitive hyaluronic acid-chitosan-g-poly(N-isopropylacrylamide) (HACPN) hydrogel for intratumoral delivery of DOX. As the degradation time of HACPN could be extended up to 3 weeks, intratumoral delivery of GOFA-DOX/HACPN could provide controlled and targeted delivery of DOX through slow degradation HACPN and subsequent cellular uptake of released GOFA-DOX by tumor cells through interactions of GOFA with folate receptors on the tumor cell’s surface. GOFA nano-carrier and HACPN hydrogel were first characterized for the physico-chemical properties. The drug loading experiments indicated the best preparation condition of GOFA-DOX was by reacting 0.1 mg GOFA with 2 mg DOX. GOFA-DOX showed pH-responsive drug release with ~5 times more DOX released at pH 5.5 than at pH 7.4 while only limited DOX was released from GOFA-DOX/HACPN at pH 7.4. Intracellular uptake of GOFA by endocytosis and release of DOX from GOFA-DOX in vitro could be confirmed from transmission electron microscopic and confocal laser scanning microscopic analysis with MCF-7 breast cancer cells. The targeting effect of FA was revealed when intracellular uptake of GOFA was blocked by excess FA. This resulted in enhanced in vitro cytotoxicity as revealed from the lower half maximal inhibitory concentration (IC50) value of GOFA-DOX (7.3 μg/mL) compared with that of DOX (32.5 μg/mL) and GO-DOX (10 μg/mL). The flow cytometry analysis indicated higher apoptosis rates for cells treated with GOFA-DOX (30%) compared with DOX (8%) and GO-DOX (11%). Animal studies were carried out with subcutaneously implanted MCF-7 cells in BALB/c nude mice and subject to intratumoral administration of drugs. The relative tumor volumes of control (saline) and GOFA-DOX/HACPN groups at day 21 were 2.17 and 1.79 times that at day 0 with no significant difference. In comparison, the relative tumor volumes of treatment groups at the same time were significantly different at 1.02, 0.67 and 0.48 times for DOX, GOFA-DOX and GOFA-DOX/HACPN groups, respectively. The anti-tumor efficacy was also supported by images from an in vivo imaging system (IVIS) using MCF-7 cells transfected with luciferase (MCF-7/Luc). Furthermore, tissue biopsy examination and blood analysis indicated that intratumoral delivery of DOX using GOFA-DOX/HACPN did not elicit acute toxicity. Taken together, GOFA-DOX/HACPN could be deemed as a safe and efficient intratumoral drug delivery system for breast cancer therapy.
Tucum-do-Cerrado (Bactris setosa Mart.) May Promote Anti-Aging Effect by Upregulating SIRT1-Nrf2 Pathway and Attenuating Oxidative Stress and Inflammation
Authors: Da Cunha Marcela , Arruda Sandra
Published: November 2017

Aging may be related to oxidative damage accumulation and a low-grade inflammation, both responses are modulated by iron and phytochemicals. This study investigated the effect of tucum-do-cerrado (Bactris setosa Mart.) consumption on the expression of sirtuins (SIRT 1 and 3) and senescence marker protein-30 (SMP30), and on the redox and inflammatory responses, in adult rats supplemented or not with dietary iron. Male Wistar rats were treated for 12 weeks with: control diet (CT); iron enriched-diet (+Fe); control diet + 15% tucum-do-cerrado (Tuc); or iron enriched-diet + 15% tucum-do-cerrado (Tuc + Fe). Iron supplementation (+Fe) increased liver, spleen and intestine iron levels, transferrin saturation, serum iron, serum TNF-α and IL-6 levels, hepatic carbonyl content and and superoxide dismutase (SOD) activity, hepatic Nrf2 protein and Nqo1 mRNA levels and decreased the renal Sirt1 mRNA levels in relation to CT group. Tucum-do-cerrado consumption (Tuc) increased hepatic SOD activity, Nrf2 and SIRT1 mRNA and protein contents, and Nqo1 mRNA levels, while it decreased the renal SOD activity compared with the CT diet. The consumption of tucum-do-cerrado associated with the iron-enriched diet (Tuc + Fe) increased the iron levels in tissues and serum transferrin saturation, compared to the CT diet, while promoting a decrease in hepatic carbonyl and renal malondialdehyde levels, marginally reducing serum IL-6 levels, and increasing hepatic SIRT1 protein content, renal Sirt1 and hepatic Nrf2 mRNA levels, compared to the +Fe group. None of the treatments altered Smp30 mRNA levels. The results suggest that tucum-do-cerrado consumption might promote an anti-aging effect by increasing SIRT1 expression, which may enhance Nrf2 mRNA and protein levels and its downstream pathway, which in turn decrease oxidative damage to proteins and the levels of inflammatory cytokines (IL-6 and TNF-α), induced by iron excess.
The Association between Serum 25(OH)D Status and Blood Pressure in Participants of a Community-Based Program Taking Vitamin D Supplements
Authors: Mirhosseini Naghmeh , Vatanparast Hassanali , Kimball Samantha
Published: November 2017

Background: Vitamin D deficiency is a risk factor for hypertension. Methods: We assessed 8155 participants in a community-based program to investigate the association between serum 25-hydroxyvitamin D (25(OH)D) status and blood pressure (BP) and the influence of vitamin D supplementation on hypertension. Participants were provided vitamin D supplements to reach a target serum 25(OH)D > 100 nmol/L. A nested case-control study was conducted to examine the effect of achieving physiological vitamin D status in those who were hypertensive and not taking BP-lowering medication, and hypertensive participants that initiated BP-lowering medication after program entry. Results: At baseline, 592 participants (7.3%) were hypertensive; of those, 71% were no longer hypertensive at follow-up (12 ± 3 months later). There was a significant negative association between BP and serum 25(OH)D level (systolic BP: coefficient = −0.07, p < 0.001; diastolic BP: coefficient = −0.1, p < 0.001). Reduced mean systolic (−18 vs. −14 mmHg) and diastolic (−12 vs. −12 mmHg) BP, pulse pressure (−5 vs. −1 mmHg) and mean arterial pressure (−14 vs. −13 mmHg) were not significantly different between hypertensive participants who did and did not take BP-lowering medication. Conclusion: Improved serum 25(OH)D concentrations in hypertensive individuals who were vitamin D insufficient were associated with improved control of systolic and diastolic BP.
Nutritional Profile and Dietary Patterns of Lebanese Non-Alcoholic Fatty Liver Disease Patients: A Case-Control Study
Authors: Fakhoury-Sayegh Nicole , Younes Hassan , Heraoui Gessica , Sayegh Raymond
Published: November 2017

Nonalcoholic fatty liver disease (NAFLD) is considered the most common liver disease in the world. Dietary habits have a significant impact on the biological and physical profile of patients and increase the risk of NAFLD. The overall pattern of diet intake is more associated with health outcomes than nutrients. The aim of this study was to evaluate the nutritional profile and the dietary patterns of Lebanese NAFLD patients and compare it with controls. During this study; 112 NAFLD Lebanese adult patients (55 men and 57 women); and 110 controls (44 men and 66 women) were recruited. Dietary intake was evaluated by two 24-h recalls and a semi-quantitative 90-item food frequency questionnaire. Dietary patterns were determined by factor analysis. Results from the study demonstrated that 40% of cases belonged to the high fruit group as compared to 30% following a high meat; fast food dietary pattern. Both groups increased the odds of NAFLD by four-fold (p < 0.05). The traditional diet decreases the odds by 33% after adjustment with the covariables. The high fruit diet group was, as with the high meat, fast food dietary pattern, the main potential risk factor for NAFLD in Lebanese patients.
Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults
Authors: Renzi-Hammond Lisa , Bovier Emily , Fletcher Laura , Miller L. , Mewborn Catherine , Lindbergh Cutter , Baxter Jeffrey , Hammond Billy
Published: November 2017

Background: Past studies have suggested that higher lutein (L) and zeaxanthin (Z) levels in serum and in the central nervous system (as quantified by measuring macular pigment optical density, MPOD) are related to improved cognitive function in older adults. Very few studies have addressed the issue of xanthophylls and cognitive function in younger adults, and no controlled trials have been conducted to date to determine whether or not supplementation with L + Z can change cognitive function in this population. Objective: The purpose of this study was to determine whether or not supplementation with L + Z could improve cognitive function in young (age 18–30), healthy adults. Design: A randomized, double-masked, placebo-controlled trial design was used. Fifty-one young, healthy subjects were recruited as part of a larger study on xanthophylls and cognitive function. Subjects were randomized into active supplement (n = 37) and placebo groups (n = 14). MPOD was measured psychophysically using customized heterochromatic flicker photometry. Cognitive function was measured using the CNS Vital Signs testing platform. MPOD and cognitive function were measured every four months for a full year of supplementation. Results: Supplementation increased MPOD significantly over the course of the year, vs. placebo (p < 0.001). Daily supplementation with L + Z and increases in MPOD resulted in significant improvements in spatial memory (p < 0.04), reasoning ability (p < 0.05) and complex attention (p < 0.04), above and beyond improvements due to practice effects. Conclusions: Supplementation with L + Z improves CNS xanthophyll levels and cognitive function in young, healthy adults. Magnitudes of effects are similar to previous work reporting correlations between MPOD and cognition in other populations.
Hydrocyclone Separation of Hydrogen Decrepitated NdFeB
Authors: Awais Muhammad , Coelho Fernando , Degri Malik , Herraiz Enrique , Walton Allan , Rowson Neil
Published: November 2017

Hydrogen decrepitation (HD) is an effective and environmentally friendly technique for recycling of neodymium-iron-boron (NdFeB) magnets. During the HD process, the NdFeB breaks down into a matrix phase (Nd2Fe14BHx) and RE-rich grain boundary phase. The grain boundary phase in the HD powder is <2 μm in size. Recycled NdFeB material has a higher oxygen content compared to the primary source material. This additional oxygen mainly occurs at the Rare Earth (RE) rich grain boundary phase (GBP), because rare earth elements oxidise rapidly when exposed to air. This higher oxygen level in the material results in a drop in density, coercivity, and remanence of sintered NdFeB magnets. The particle size of the GBP is too small to separate by sieving or conventional screening technology. In this work, an attempt has been made to separate the GBP from the matrix phase using a hydrocyclone, and to optimise the separation process. HD powder, obtained from hard disk drive (HDD) scrap NdFeB sintered magnets, was used as a starting material and passed through a hydrocyclone a total number of six times. The X-ray fluorescence (XRF) analysis and sieve analysis of overflows showed the matrix phase had been directed to the underflow while the GBP was directed to the overflow. The optimum separation was achieved with three passes. Underflow and overflow samples were further analysed using an optical microscope and MagScan and matrix phase particles were found to be magnetic.
Burned Area Mapping in the Brazilian Savanna Using a One-Class Support Vector Machine Trained by Active Fires
Authors: Pereira Allan , Pereira José , Libonati Renata , Oom Duarte , Setzer Alberto , Morelli Fabiano , Machado-Silva Fausto , De Carvalho Luis
Published: November 2017

We used the Visible Infrared Imaging Radiometer Suite (VIIRS) active fire data (375 m spatial resolution) to automatically extract multispectral samples and train a One-Class Support Vector Machine for burned area mapping, and applied the resulting classification algorithm to 300-m spatial resolution imagery from the Project for On-Board Autonomy-Vegetation (PROBA-V). The active fire data were screened to prevent extraction of unrepresentative burned area samples and combined with surface reflectance bi-weekly composites to produce burned area maps. The procedure was applied over the Brazilian Cerrado savanna, validated with reference maps obtained from Landsat images and compared with the Collection 6 Moderate Resolution Imaging Spectrometer (MODIS) Burned Area product (MCD64A1) Results show that the algorithm developed improved the detection of small-sized scars and displayed results more similar to the reference data than MCD64A1. Unlike active fire-based region growing algorithms, the proposed approach allows for the detection and mapping of burn scars without active fires, thus eliminating a potential source of omission error. The burned area mapping approach presented here should facilitate the development of operational-automated burned area algorithms, and is very straightforward for implementation with other sensors.
Comparison of Retrieved L2 Products from Four Successive Versions of L1B Spectra in the Thermal Infrared Band of TANSO-FTS over the Arctic Ocean
Authors: Payan Sébastien , Camy-Peyret Claude , Bureau Jérôme
Published: November 2017

This paper concentrates on the calibration/validation of the Thermal and Near Infrared Sensor for Carbon Observation (TANSO)–Fourier Transform Spectrometer (FTS) spectra in the thermal infrared (TIR) spectral region (B4 band) over the Arctic Ocean. We have performed inter-comparisons of the retrieved L2 products from four successive versions of L1B products (V150, V160, V201, V203) to check the differences and the improvement in the spectral and radiometric calibration of TANSO-FTS spectra in the narrow spectral domain of 940–980 cm−1 covering CO2 lines of the so-called laser band in the rather clear 10.4 μm atmospheric window, allowing sounding down to the lowest atmospheric layers. To our knowledge, this is the first attempt to retrieve XCO2 from this spectral region. The period covered is the summer months (July, August, September) and the years from 2009 to 2015. Internal comparisons of L1B TANSO-FTS spectra, as well as comparisons of retrieved L2 products, i.e., Tsurf (sea surface temperature or SST) and the retrieved column-averaged dry air volume mixing ratio XCO2 derived with the same algorithm are presented. The overall trend in the CO2 column-averaged VMR is well captured over the six year period for Green-house Gases Observing Satellite (GOSAT), but calibration issues are still hindering the use of TANSO-FTS TIR spectra for accurate and stable XCO2 and Tsurf products. However, an internal comparison of the successive L1B versions is possible and helpful to make progress with respect to the radiometric and spectral calibration TIR spectra collected by TANSO-FTS on GOSAT.
Temporal and Spatial Comparison of Agricultural Drought Indices from Moderate Resolution Satellite Soil Moisture Data over Northwest Spain
Authors: Pablos Miriam , Martínez-Fernández José , Sánchez Nilda , González-Zamora Ángel
Published: November 2017

During the last decade, a variety of agricultural drought indices have been developed using soil moisture (SM), or any of its surrogates, as the primary drought indicator. In this study, a comprehensive study of four innovative SM-based indices, the Soil Water Deficit Index (SWDI), the Soil Moisture Agricultural Drought Index (SMADI), the Soil Moisture Deficit Index (SMDI) and the Soil Wetness Deficit Index (SWetDI), is conducted over a large semi-arid crop region in northwest Spain. The indices were computed on a weekly basis from June 2010 to December 2016 using 1-km satellite SM estimations from Soil Moisture and Ocean Salinity (SMOS) and/or Moderate Resolution Imaging Spectroradiometer (MODIS) data. The temporal dynamics of the indices were compared to two well-known agricultural drought indices, the atmospheric water deficit (AWD) and the crop moisture index (CMI), to analyze the levels of similarity, correlation, seasonality and number of weeks with drought. In addition, the spatial distribution and intensities of the indices were assessed under dry and wet SM conditions at the beginning of the growing season. The results showed that the SWDI and SMADI were the appropriate indices for developing an efficient drought monitoring system, with higher significant correlation coefficients (R ≈ 0.5–0.8) when comparing with the AWD and CMI, whereas lower values (R ≤ 0.3) were obtained for the SMDI and SWetDI.
Spatial-Temporal Dynamics of Cropping Frequency in Hubei Province over 2001–2015
Authors: Tao Jianbin , Wu Wenbin , Liu Wenbin
Published: November 2017

Mapping crop patterns with remote sensing data is of great importance for agricultural production, food security and agricultural sustainability. In this paper, a hierarchical clustering method was proposed to map cropping frequency from time-series Moderate Resolution Imaging Spectroradiometer (MODIS) Enhanced Vegetation Indices (EVI) data and the spatial and temporal patterns of cropping frequency from 2001 to 2015 in Hubei Province of China were analyzed. The results are as follows: (1) The total double crop areas decreased slightly, while total single crop areas decreased significantly during 2001 and 2015; (2) The transfer between double crop and single crop was frequent in Hubei with about 11~15% croplands changed their cropping frequency every 5 years; (3) The crop system has obvious regional differentiation for their change trend at the county level.
Acoustic Sensors Based on Amino-Functionalized Nanoparticles to Detect Volatile Organic Solvents
Authors: Matatagui Daniel , Kolokoltsev Oleg , Saniger José Manuel , Gràcia Isabel , Fernández María Jesús , Fontecha Jose Luis , Horrillo María del Carmen
Published: November 2017

Love-wave gas sensors based on surface functionalized iron oxide nanoparticles has been developed in this research. Amino-terminated iron oxide nanoparticles were deposited, by a spin coating technique, onto the surface of Love-wave sensors, as a very reproducible gas-sensing layer. The gases tested were organic solvents, such as butanol, isopropanol, toluene and xylene, for a wide and low concentration range, obtaining great responses, fast response times of a few minutes (the time at which the device produced a signal change equal to 90%), good reproducibilities, and different responses for each detected solvent. The estimated limits of detection obtained have been very low for each detected compound, about 1 ppm for butanol, 12 ppm for isopropanol, 3 ppm for toluene and 0.5 ppm for xylene. Therefore, it is demonstrated that this type of acoustic wave sensor, with surface amino-functionalized nanoparticles, is a good alternative to those ones functionalized with metal nanoparticles, which result very expensive sensors to achieve worse results.
High Rates of Suicide and Violence in the Lives of Girls and Young Women in Bangladesh: Issues for Feminist Intervention
Authors: Bagley Christopher , Shahnaz Afroze , Simkhada Padam
Published: November 2017

Deaths by suicide in Bangladesh have an atypical sex ratio, with higher rates in females than in males—a characteristic shared with several countries in Southern Asia. Reasons for this are explored in this paper. An examination of the social structure of Bangladesh suggests that girls and women are subjected to higher rates of sexual and physical violence compared with males, especially in rural and urban slum areas. This violence is often linked to the enforced marriage of young girls to older men. A systematic review of 24 studies on suicide and suicidal behaviors in Bangladesh has shown that suicide death rates are exceptionally high in younger women, at a rate of about 20 per 100,000, more than twice the rate in males aged less than 49. In girls aged 15 to 17, the estimated suicide rate is 14 per 100,000, 50% higher than in males. Because of problems in obtaining systematic data on deaths by suicide, these rates are likely to be underestimates. Extreme poverty and lack of education have been recorded as factors in deaths by suicide, although there are methodological problems in reaching such conclusions. We speculate that some of the “suicides” (especially those using poison) may in fact be cases of murder. A dowry system (not sanctioned by Islam) is thought to be a major cause of family poverty, and violence experienced by young girls. In proposing solutions, we argue the case (as Muslims) for the support of an Islamic feminism which urges better support for girls growing up in extreme poverty.
Sustainable Urban Agriculture in Ghana: What Governance System Works?
Authors: Nchanji Eileen
Published: November 2017

Urban farming takes advantage of its proximity to market, transport and other urban infrastructure to provide food for the city and sustain the livelihoods of urban and peri-urban dwellers. It is an agricultural activity which employs more than 50% of the local urban population with positive and negative impacts on local and national development. Urban agriculture is an informal activity not supported by law but in practice is regulated to a certain extent by state institutions, traditional rulers, farmers and national and international non-governmental organisations. Tamale’s rapid population growth, exacerbated by the unplanned development system and institutional conflicts, are factors contributing to the present bottlenecks in the urban agricultural system. In this paper, these bottlenecks are conceptualised as problems of governance. These issues will be illustrated using ethnographic data from land sales, crop-livestock competition, waste-water irrigation, and markets. I will explain how conflicts which arise from these different situations are resolved through the interactions of various governance systems. Informal governance arrangements are widespread, but neither they nor formal systems are always successful in resolving governance issues. A participatory governance does not seem possible due to actors’ divergent interests. A governance solution for this sector is not yet apparent, contributing to food and nutritional insecurity.
Neutrosophic Duplet Semi-Group and Cancellable Neutrosophic Triplet Groups
Authors: Zhang Xiaohong , Smarandache Florentin , Liang Xingliang
Published: November 2017

The notions of the neutrosophic triplet and neutrosophic duplet were introduced by Florentin Smarandache. From the existing research results, the neutrosophic triplets and neutrosophic duplets are completely different from the classical algebra structures. In this paper, we further study neutrosophic duplet sets, neutrosophic duplet semi-groups, and cancellable neutrosophic triplet groups. First, some new properties of neutrosophic duplet semi-groups are funded, and the following important result is proven: there is no finite neutrosophic duplet semi-group. Second, the new concepts of weak neutrosophic duplet, weak neutrosophic duplet set, and weak neutrosophic duplet semi-group are introduced, some examples are given by using the mathematical software MATLAB (MathWorks, Inc., Natick, MA, USA), and the characterizations of cancellable weak neutrosophic duplet semi-groups are established. Third, the cancellable neutrosophic triplet groups are investigated, and the following important result is proven: the concept of cancellable neutrosophic triplet group and group coincide. Finally, the neutrosophic triplets and weak neutrosophic duplets in BCI-algebras are discussed.
Membrane-Active Properties of an Amphitropic Peptide from the CyaA Toxin Translocation Region
Authors: Voegele Alexis , Subrini Orso , Sapay Nicolas , Ladant Daniel , Chenal Alexandre
Published: November 2017

The adenylate cyclase toxin CyaA is involved in the early stages of infection by Bordetella pertussis, the causative agent of whooping cough. CyaA intoxicates target cells by a direct translocation of its catalytic domain (AC) across the plasma membrane and produces supraphysiological levels of cAMP, leading to cell death. The molecular process of AC translocation remains largely unknown, however. We have previously shown that deletion of residues 375–485 of CyaA selectively abrogates AC translocation into eukaryotic cells. We further identified within this “translocation region” (TR), P454 (residues 454–484), a peptide that exhibits membrane-active properties, i.e., is able to bind and permeabilize lipid vesicles. Here, we analyze various sequences from CyaA predicted to be amphipatic and show that although several of these peptides can bind membranes and adopt a helical conformation, only the P454 peptide is able to permeabilize membranes. We further characterize the contributions of the two arginine residues of P454 to membrane partitioning and permeabilization by analyzing the peptide variants in which these residues are substituted by different amino acids (e.g., A, K, Q, and E). Our data shows that both arginine residues significantly contribute, although diversely, to the membrane-active properties of P454, i.e., interactions with both neutral and anionic lipids, helix formation in membranes, and disruption of lipid bilayer integrity. These results are discussed in the context of the translocation process of the full-length CyaA toxin.
Linkage Analysis of Land Use/Cover Patterns and Hydro-Chemical Characteristics in Different Seasons in Ebinur Lake Watershed, China
Authors: Wang Juan , Zhang Fei , Kung Hsiang-te , Ren Yan , Zhang Yue , Yu Haiyang
Published: November 2017

Ebinur Lake Watershed, with its oases and deserts, is a typically arid and mountainous region on the northern slope of Tianshan Mountains. Along with ever increasing human activities, agricultural and domestic wastes have been directly discharged into river systems around the Watershed, which consequently poses a grave threat to the sustainable development of Xinjiang. Through statistical and spatial analysis, we have determined the relationships between land use/cover (LULC) and hydro-chemical characteristics during rainy and dry seasons in 2014. Spatial patterns of hydro-chemical characteristics as demonstrated by mineralization, pH, electrical conductivity (EC), and SO42−, HCO3−, Cl−, Mg2+, Na+, Ca2+ and K+ concentrations were examined in 113 sites. Since hydro-chemical characteristics were affected by LULC patterns, this study delineated six zones to analyze the distribution characteristics of hydro-chemical parameters and its relationship with LULC patterns. The results showed that, except for the pH, all variables demonstrated significant spatial differences during dry and rainy seasons. In addition, the relationships between water quality and LULC patterns indicated that the farmland, forest–grassland, water body and salinized land all affected hydro-chemical characteristics during both rainy and dry seasons. Especially, decreased rainfall, irrigation, surface runoff, the area of lake, etc. largely led to the increase in ion content, which had great influence on hydro-chemical characteristics parameters in dry season. Furthermore, we established several stepwise linear multiple regressions models. The results showed that pH, mineralization and Ca2+ were defined by forest-grassland, while the Cl− and Mg2+ were defined by salinized land during the rainy season. The pH and Na+ were estimated based on farmland, whereas Cl− and Ca2+ were estimated based on forest-grassland during the dry season. In conclusion, this research on the relationships between the spatial distribution of hydro-chemical characteristics in Ebinur Lake Watershed and LULC patterns will be significant for the sustainable management of the arid regions in northwest China.