bluuebunny/crossref_metadata_2025 huggingface dataset:
Esketamine pretreatment during cesarean section reduced the incidence of PPD: A randomized controlled trail
Authors: Xu Shixia , Yang Jiaojiao , Li Jing , Zhang Min , Sun Jie , Liu Qingren , Yang Jianjun
Published: November 2023

Background
Postpartum depression (PPD) is a common mental disease in postpartum women, which has received more and more attention in society. Ketamine has been confirmed for its rapid antidepressant effect in women with PPD. We speculate that esketamine, an enantiomer of ketamine, pretreatment during cesarean can also reduce the incidence of PPD.
Methods
All the parturients enrolled in the study were randomly assigned to two groups: the esktamine group (0.2 mg/kg esketamine) and the control group (a same volume of saline). All the drugs were pumped for 40 min started from the beginning of the surgery. The Amsterdam Anxiety and Information Scale (APAIS) scores before the surgery, the Edinburgh postnatal depression scale (EPDS) scores at 4 d and 42 d after surgery, the Pain Numerical Rating Scale (NRS) scores at 6 h, 12 h, 24 h and 48 h post-operation were evaluated, as well as the adverse reactions were recorded.
Results
A total of 319 parturients were analyzed in the study. The incidence rate of PPD (EPDS score > 9) in the esketamine group was decreased than the control group at 4 days after surgery (13.8% vs 23.1%, P = 0.0430 ) but not 42 days after surgery (P = 0.0987). Esketamine 0.2 mg/kg could reduce the NRS score at 6 h,12 h and 24 h after surgery, as well as the use of vasoactive drugs during surgery (P < 0.05). The incidences of maternal dizziness (17.0%), blurred vision (5%), illusion (3.8%) and drowsiness (3.8%) in the esketamine group were higher than those of control group (P < 0.05).
Conclusions
Intraoperative injection of esketamine (0.2 mg/kg) prevented the occurrence of depression (EPDS score > 9) at 4 days after delivery but not 42 days. Esketamine reduced the NRS scores at 6 h, 12 h and 24 h after surgery, but the occurrence of maternal side effects such as dizziness, blurred vision, drowsiness and hallucination were increased.
Trial registration:
Registered in the Chinese Clinical Trial Registry (ChiCTR2100053422) on 20/11/2021.
Autopolyploidization effect on morpholological, anatomical, reproductive variations and andrographolide content in Andrographis paniculata (Burm. f.) Nees.
Authors: PRIYA LEKSHMI , P Shibin Felix , PILLAI P R UNNIKRISHNA
Published: November 2023

Artificial polyploidy induction plays a major role in improving various characteristics of the plants. Polyploidization has found widespread application in the breeding of new varieties of medicinal plants due to its numerous advantages and superior performance when compared to their diploid counterparts. This study was undertaken to evaluate the impact of artificial polyploidy on various characteristics of the medicinal plant Andrographis paniculata (Burm. f.) Nees. Aqueous colchicine was applied to Kalmegh seedlings at three different concentrations: 0.05%, 0.1%, and 0.2% (w/v), with varying exposure durations of 6, 12, and 24 h. The duplication of DNA content in induced polyploid plants was confirmed by employing flow cytometry analysis. The most successful induction of polyploidy was accomplished by administering 0.1% (w/v) colchicine for duration of 12 h. The polyploid plants achieved were shorter but with thicker stems, larger leaves, increased leaf area and thickness, larger seeds and flower characteristics than their diploid intact plants. The length and width of stomata were increased in induced polyploid plants, whereas stomata density and index was decreased, in contrast with initial diploid plants. This work follows a facile immersion method and also includes the stomatal and seed detailing of polyploid A. paniculata using SEM. High Performance Liquid Chromatography (HPLC) analysis showed notable (200 fold) increases in andrographolide content of polyploid plants (1.6mg/100g) in contrast with those of diploid plants (0.008mg/100g). Polyploidization also holds significant potential as a breeding technique for future breeding programs involving A. paniculata.
Sequence-ensemble-function relationships for disordered proteins in live cells
Authors: Holehouse Alex , Emenecker Ryan , Guadalupe Karina , Shamoon Nora , Sukenik Shahar
Published: November 2023

Intrinsically disordered protein regions (IDRs) are ubiquitous across all kingdoms of life and play a variety of essential cellular roles. IDRs exist in a collection of structurally distinct conformers known as an ensemble. IDR amino acid sequence determines its ensemble, which in turn can play an important role in dictating molecular function. Yet a clear link connecting IDR sequence, its ensemble properties, and its molecular function in living cells has not been systematically established. Here, we set out to test this sequence-ensemble-function paradigm using a novel computational method (GOOSE) that enables the rational design of libraries of IDRs by systematically varying specific sequence properties. Using ensemble FRET, we measured the ensemble dimensions of a library of rationally designed IDRs in human-derived cell lines, revealing how IDR sequence influences ensemble dimensions in situ. Furthermore, we show that the interplay between sequence and ensemble can tune an IDR’s ability to sense changes in cell volume - a de novomolecular function for these synthetic sequences. Our results establish biophysical rules for intracellular sequence-ensemble relationships, enable a new route for understanding how IDR sequences map to function in live cells, and set the ground for the design of synthetic IDRs with de novo function.
Physiological and molecular responses of basil (Ocimum basilicum) to silver stress: A comparison between silver nanoparticles and silver nitrate treatments
Authors: Zareei Ali , Abbaspour Hossein , Peyvandi Maryam , Majd Ahmad
Published: November 2023

With the extensive utilization of nanotechnology, silver nanoparticles (AgNPs) are prevalent nanomaterials that may entail ecological risks by their potential translocation into plant systems. The present study investigated the physiological and molecular responses of basil seedlings (Ocimum basilicum) subjected to AgNPs or silver nitrate (AgNO3) for 7 days. The seedlings were treated with 0, 4, 10, or 40 mg/L of AgNO3 or AgNPs in Hoagland’s solution. Both treatments resulted in significant accumulation of Ag in the roots and shoots, with higher levels in the roots of AgNO3-treated seedlings. AgNPs increased plant biomass at 4 mg/L, while AgNO3 decreased it at all concentrations. Both treatments reduced the total chlorophyll, carotenoids, and carbohydrates, with more pronounced effects in AgNO3-treated seedlings. Both treatments also induced oxidative stress, as indicated by increased levels of H2O2, MD, and proline, and enhanced activity of antioxidant enzymes SOD, CAT, and APX. However, these responses were more evident in AgNO3-treated seedlings, especially at higher concentrations. Quantitative real-time PCR analysis revealed that both treatments induced the upregulation of genes encoding oxidative stress tolerance-related enzymes, such as FSD1, MSD1, CSD1, CATa, CATb, APXa and APXb, in the basil seedling shoots. These results suggest that AgNPs are less toxic to basil plants than AgNO3 and that basil plants can activate physiological and molecular mechanisms to cope with Ag-induced oxidative stress.
Phosphoric Acid Network Induced by Surface Ligands Shifts the Selectivity for Uranium Extraction over Single Atom Modified TiO2 Catalysts
Authors: Yao Tao , Li Mingzhe , Zhang Fucheng , Dong Huanhuan , Chen Tao , Fu Jiang , Ding Tao , Zhu Wen-Kun
Published: November 2023

Photo-driven uranium extraction from fluorine-containing uranium wastewater is considered as a promising avenue to overcome the difficulty of uranium extraction in traditional uranium treatment technologies. Herein, we report a photocatalyst composed of Mn single atoms located at hollow TiO2 nanospheres with organophosphorus acid modification (Mn-SAs/TiO2@HEDP) for efficient uranium extraction from fluorine-containing uranium wastewater. Notably, the synergistic effect of the single-atoms and organophosphorus acid modification in the hollow TiO2 nanosphere significantly enhances the charge separation/transfer efficiency and photo-electron lifetime, thereby greatly boosting the photo-assisted uranium extraction activity. Accordingly, Mn-SAs/TiO2@HEDP show a considerable U(VI) removal rate of 94% in fluorine-containing uranium wastewater. By virtue of the reaction kinetics parameters and DFT calculation, we have confirmed that the phosphoric acid network induced by surface ligands over Mn SAC-TiO2 with Ti-O-P charge transfer channels can significantly enhance the selectivity and reaction kinetics for uranyl ions, relative to modifying inorganic phosphates. Relying on the X-ray absorption spectroscopy technique, we further confirm the dissociate uranyl ions were captured by the interlocking phosphate network to form the sturdy 2Oax-1U-4Oeq configuration, further verifying photo-driven fluorine uranium separation. This study provides a precedent for the design of advanced photocatalysts with specific recognition and a theoretical guide for the treatment of fluorine-containing uranium wastewater.
Study on molecular mechanisms related to hepatic fibrosis by Mendelian randomization combined with transcriptome analysis
Authors: HUANG LIANGJIANG , HUANG GUOCHU , WANG MENG , MAO DEWEN , WANG MINGGANG , ZHENG JINGHUI , ZHANG RONGZHEN , LONG FULI , YAO FAN , YAO CHUN
Published: November 2023

Background Recent studies have proved the association between the gut microbiota (GM) through gut-brain axis and liver diseases, including hepatic fibrosis (HF) and hepatic encephalopathy (HE). Nevertheless, the specific gut microbial taxa identified in these studies have shown variability. Furthermore, it's important to note that observational studies cannot definitively demonstrate causation.Our study aims to explain the potential causal relationship between gut flora and HF and HE through transcriptome and Mendelian randomization analysis.Methods: A Mendelian randomization study was conducted using pooled statistics from the MiBioGen database of genome-wide Association Studies (GWAS) of GM and HF. The main analytical method for evaluating causality was the inverse variance weighting (IVW) method. In addition, sensitivity analyses were performed using Cochrane's Q test, MR-Egger intercept test, MR-PRESSO global test and leave-one analysis. Subsequently, transcriptomic analysis was conducted to assess variations in gene expression in patients with HF, investigating their potential correlations with immune cell infiltration and immune factor levels. The relationship between these genes and HE was also investigated.Results: At the site significance level, it was found that the presence of Lachnospiraceae(OR = 1.981, 95%CI: 1.183 − 3.315, P = 0.009) may be associated with a high risk of HF, while Butyricicoccus(OR = 0.414, 95%CI: 0.227 − 0.756, P = 0.004) is associated with a low risk of HF. In addition, SNP-related genes were extracted in the expression profile of GSE57193, which were successively COPG2, KLF14 and TSGA13. Our study also revealed the differences in the expression of related genes in patients with HF, as well as correlations with levels of immune cell infiltration and immune factors. The results revealed that these genes are significantly associated with immune cells and immune factors and play an important role in the immune microenvironment. At the same time, this study also explored the relationship between these genes and hepatic encephalopathy and discovered that they are significantly correlated with the regulatory genes of HE and are regulated by multiple transcription factors and signaling pathways.Conclusion: Our study is the first to apply transcriptome and Mendelian randomization analysis to explain the potential causal relationship between gut flora and HF and HE. These findings shed new light on the molecular mechanisms between gut flora and HF and hepatic encephalopathy and may provide valuable insights into their underlying mechanisms for further investigation.
Comparison of clinical outcomes between sequestered cervical disc herniation and non- sequestered cervical disc herniation after anterior cervical decompression and fusion: a cohort study
Authors: Jin Lanbo , Sun Ke , Liu Gang , Yuan Wen , Chen Huajiang , Tian Ye
Published: November 2023

Background
The advantages of anterior cervical decompression and fusion (ACDF) were well published, while research on postoperative results in different subtypes of cervical disc herniation (CDH) still remain blank. This study aimed to explore the operational effect between sequestration and other types in CDH.
Methods
This retrospective cohort study enrolled 108 patients treated with ACDF in our hospital. The participants were divided into two groups according to the existence of sequestered disc. The Visual analog scale(VAS) score, the Japanese Orthopedics Association(JOA)score and the Neck disability index(NDI) score were used to evaluate postoperative outcome.
Results
Significant improvements were observed in both groups at every viewpoint(P < 0.001). The mean JOA was 15.04 ± 1.26 in sequestered disc group and was 14.45 ± 1.43 in non-sequestered disc group two months after operation (P = 0.026 < 0.05). The improvement of JOA in two months after ACDF showed statistical difference:46.58%±39.17% in sequestered disc group and 33.39%±28.82% in non-sequestered disc group(p = 0.047 < 0.05).32 patients in sequestered disc group (64%) and 19 patients in non-sequestered disc group (32.76%) were presented with high signal intensity of spinal cord on preoperative cervical T2-weighted MRI, with statistical difference (P < 0.001).
Conclusions
Patients with sequestered cervical disc seemed to have a higher degree of symptom improvement two months after ACDF. CDH with sequestered disc appears to be more likely to cause high signal intensity changes in the compressed cervical spine on T2-weighted MRI. We prefer early positive surgery in patients with sequestered cervical disc from the clinical point of view.
WITHDRAWN: Episodic intensification of marine phosphorus burial over the last 80 million years
Authors: Li Dengfeng , Peng Jin-zhou , Poulton Simon , Chew David , O'Sullivan Gary , Fu Yu , Sun Xiao-ming
Published: November 2023

Marine phosphatization events cause episodic carbonate fluorapatite (CFA) precipitation on seamounts, and are commonly linked to growth hiatuses in ferromanganese (Fe-Mn) crusts. However, the full record of these events and their paleoenvironmental implications remain poorly understood, in large part due to poor age constraints. Here, we apply U-Pb dating to CFA in Fe-Mn crusts from the Western Pacific seamounts, representing the Earth’s oldest oceanic crust. These data reveal six distinct phosphatization events, which are aligned with Sr isotope records in CFA and phosphorite from both the Western Pacific and the Atlantic. This newly established CFA chronology tightens the timespan of phosphatization events and refines the age framework of Fe-Mn crusts. We subsequently utilize a multiproxy approach to demonstrate that the phosphatization events occurred coeval with the expansion of oceanic oxygen minimum zones. The Western Pacific Fe-Mn crusts thus document major perturbations in global oceanic phosphorus cycling, which appear to have been driven by climate-induced increases in primary productivity.
Stablity Analysis of roadbed under Flood Scouring
Authors: Wang Rui , Tang Hongmei , Zhou Fuchuan
Published: November 2023

Roadbed along the river suffers from water erosion at the bottom and collapse at the top under flood scouring, which leads to the suspension of upper pavement slab. In order to ensure the safety of roadbed along the river, this study explored the development mechanism of roadbed damage by flood in actual cases, and proposed the evolution process of instability under roadbed scouring. The stability law of roadbed along the river under flood scouring was analyzed, and the stability safety factor was corrected to analyze the sensitivity of water depth, flow rate, river bending angle and stability safety factor K in working conditions. The sensitivity of width and height of roadbed after flood scouring to water depth, flow velocity, river bending angle was investigated. Moreover, numerical simulation was carried out to determine the displacement nephogram and maximum shear stress nephogram of roadbed along the river under the conditions of road surface and roadbed load, vehicle loading or constant change of water depth. By comparing the above theories and engineering cases, the water damage mechanism of roadbed along the river was further verified.
Interstate Air Pollution Governance in the United States: Exploring Clean Air Act Section 126
Authors: Underwood Alixandra , Marcantonio Richard , Wood Danielle , Crippa Paola
Published: November 2023

Toxic air pollution is arguably the most pressing human health concern today, accounting for approximately 7–9 million premature deaths worldwide. In the United States, more than 200,000 early deaths are attributable to air pollution and almost half of these are estimated to result from emissions originating in neighboring states–i.e., transboundary air pollution. Yet more than 40% of these deaths are assessed to be cause by air pollution produced by neighboring states. This article examines the governance mechanisms used by the US to address this transboundary issue, with a focus on section 126 of the Clean Air Act. All section 126 petitions submitted from 2000–2022 (N = 13), critical factors including case length, evidence used, and case outcome are compiled and assessed using comparative case analysis. From this analysis, four main issues and corresponding recommendations to enhance US governance mechanisms related to section 126 are developed: the need for policy and procedural reforms to adjust the burden of proof on petitioning states the need for clarity on the criteria for sufficient evidence for petitioners; potential practical measures to address challenges with response timelines in petitioning process; and the means by which section 126 petitioning capacity can be made accessible to all states. The article concludes with a discussion on the significance of modeling techniques employed in the petitioning process by the US EPA and states to facilitate informed–and fair–decision-making processes.
Assessing rainfall triggering of shallow landslides with an automatic tool generating rainfall thresholds: a case study in the Alpes Maritimes region, France
Authors: Barthélemy Sophie , Bernardie Séverine , Grandjean Gilles
Published: November 2023

In this work, we use a statistical approach for modeling shallow landslide rainfall thresholds (Caine 1980) with a case study for the Alpes-Maritimes region (France). Cumulated rainfall / duration (ED) thresholds are obtained with the CTRL-T algorithm (Melillo and al. 2018) for different non-exceedance probabilities from a landslide and two climate datasets. This tool allows to automatically define rainfall events that might trigger landslides, ensuring robustness and objectivity in this process. The first climate dataset stores high resolution gridded rainfall data (1km resolution, hourly), which provides rainfall data with high temporal and spatial accuracy. This dataset, coming from radar data, is calibrated with rainfall gauges, ensuring a higher accuracy of the rainfall measurements. It provides the rainfall records directly used in the threshold construction The second dataset contains lower resolution gridded rainfall, snow, temperature, and evapotranspiration data (8km resolution, daily); it enables to assess the region’s climate through parameters imported in CTRL-T. The thresholds are then validated using a method designed by Gariano and al. (2015). Several improvements are made to the initial method. First, evapotranspiration values approximated in the process are replaced by values from the second climate dataset, the result accounting best for the regional climate. Then, computing duration values used for isolating events and sub-events for each mesh point allows to consider the heterogeneity of the Alpes-Maritimes climate. Rainfall thresholds are eventually obtained, successively from a set of probable conditions (MRC) and a set of highly probable conditions (MPRC). The validation process strengthens the analysis as well as enables to identify best performing thresholds. This work represents novel scientific progress towards landslide reliable warning systems by (a) making a case study of empirical rainfall thresholds for Alpes-Maritimes, (b) using high-resolution rainfall data and (c) adapting the method to climatically heterogeneous zones.
Increased dependence on nitrogen-fixation of a native legume in response to alien plant invasion
Authors: Han Meixu , Zhang Haiyang , Liu Mingchao , Tang Jinqi , Guo Xiaocheng , Ren Weizheng , Zhao Yong , Yang Qingpei , Guo Binglin , Han Qinwen , Feng Yulong , Feng Zhipei , Yang Xitian , Kong Deliang
Published: November 2023

Background and aims
Inhibition of nutrient acquisition by roots or their symbiotic microorganisms, such as mycorrhizal fungi and rhizobium, is an important for the success of alien plants invasion. However, we know little about how the invasive and native plants interact regarding the ‘quantity’ and ‘activity’ of the strategies, both of which are essential for plant nutrient acquisition.
Methods
Here we conducted a pot experiment by monoculture and mixed plantings of an invasive plant, Xanthium strumarium, and a widespread native legume, Glycine max, and a suite of traits of fine roots and nodules as well as mycorrhizal colonization were measured.
Results
Compared with monoculture, fine root ‘quantity’ (biomass, and surface area) and ‘activity’ (root nitrogen (N) concentration and acid phosphatase activity) of G. max both decreased in mixture plantings; nodule ‘quantity’ (biomass) decreased by 45%, while nodule N-fixing ‘activity’ (nifH gene copies) increased by 106%; mycorrhizal colonization rate remained unchanged. Contribution of N-fixation to leaf N content (%Ndfa) in G. max increased after mixed plantings; this arised from lowered rhizosphere soil N of G. max in mixed planting. Increased root ‘quantity’ and ‘activity’ together with higher mycorrhizal colonization rate of X. strumarium was observed in the mixed planting.
Conclusion
Although the legume plant can produce plenty of N resource through N-fixing of nodules, the invasive plant does not scavenge nutrients directly from N-fixing nodules, but rather deplete rhizosphere soil N of the legume crop through root strategy of the invasive plant, thereby inhibiting native root strategy while enhancing N-fixation ‘activity’.
Loneliness, self-care and activities of daily living among older adults: A Partial Least Squares Model
Authors: Masoudi Nazanin , Sarbazi Ehsan , Soleimanpour Hassan , Abbasian Mehdi , Ghasemi Masouma , Rostami Zahra , Azizi Hosein , Soleimanpour Maryam
Published: November 2023

Background: This study was conducted with the aim of investigating the feelings of loneliness and its relationship with self-care and Activities of Daily Living (ADL) among the older adults of Tabriz city.
Methods:In this observational cross-sectional study, older adults were interviewed face-to-face. Participants were selected randomly from Iran’s Integrated Health System (IIHS) framework. Three questionnaires including de Jong Gierveld Loneliness Scale, Persian version of self-care scale, and ADL-Katz were used for data collection. The Partial Least Squares and Spearman’s correlation were used to investigate the relationships between demographic characteristics, loneliness, self-care, and ADL.
Results: The sample comprised 315 respondents 51.1% were female, 49.5% had a middle school literacy and 86% were married. A significant relationship was observed between loneliness and self-care (P<0.001 and r =-0.311). Demographic characteristics such as age and marital status negatively moderated the relationships between loneliness and self-care (path coefficient -0.07, P=0.044). ADL was positively associated with self-care (path coefficient 0.41, p =0.046) and also a direct and significant relationship was observed between ADL and daily self-care (P<0.001 and r=0.335).
Conclusion: The feeling of loneliness and its inverse relationship with self-care, which is more crucial in elderlies than other people, indicates the importance of studying the feeling of loneliness in the older adults, and further studies are necessary to investigate more and make a plan of action.
Study Protocol: Evaluation of a multisite community-based participatory project to achieve full childhood immunization coverage in Mozambique and Malawi (Let’s talk about vaccines project)
Authors: Shuro Linda , Lawrence Emily , Knight Lucia , Schneider Helen , Tabana Hanani
Published: November 2023

Background
Full coverage of childhood vaccines is a persistent challenge in low- and middle-income countries, with the emergence of the COVID-19 pandemic further worsening the situation. The complementary use of community-based participatory research (CBPR) and human-centered design (HCD) approaches has the potential to effectively create tailored solutions (interventions) to improve public health outcomes. The Let’s talk about vaccines! project is a multisite community-based participatory project by VillageReach which uses the human- centered design approach to identify the barriers and co-create solutions to address under- two routine immunization access and uptake in Malawi and Mozambique. There are a few examples of evaluations of interventions created through human-centered design. This manuscript outlines a study protocol describing the evaluation of VillageReach’s participatory solution development and solution implementation (intervention-Let’s talk about vaccines Project).
Methods
Guided by the RE-AIM (Reach Effectiveness Adoption Implementation Maintenance) framework, this three-year evaluation prospectively evaluates the effectiveness (on under-two immunization coverage) of VillageReach’s intervention and processes of implementation (reach, adoption, implementation and maintenance) in two districts in Mozambique and two in Malawi. This paper will also describe the theory of change for VillageReach’s intervention. Thematic analysis will be used to analyze the qualitative data, and interrupted time series analysis used to analyze the intervention’s effectiveness on specific under-two immunization outcomes. Complex systems thinking with consideration of constructs inherent in health systems strengthening will be applied in the overall analysis. Findings will inform the development of a comprehensive framework to guide scalability of community-based approaches on childhood immunization uptake and access into similar contexts.
Discussion
This study is among the few studies to evaluate a public health intervention (solution) created through CBPR and HCD. This protocol provides examples of methods to evaluate the use of these novel approaches in low- and middle-income countries. The evaluation will be fundamental in providing evidence of the solution impact as well as informing scalability of the solution(s) to similar contexts. It will also contribute to the evidence base on mechanisms that explain observed improvements in under- two immunization outcomes as a result of codesigned community-driven solutions.
Carbon Black Wood Fiber for Efficient and Low Humidity Moisture-Enabled Electric Generation
Authors: Zhang Tao , Han Xuewen , Peng Yukang , Yu Han , Pu Junwen
Published: November 2023

With the rapid development of modern society, our demand for energy is increasing. And the extensive use of fossil energy has triggered a series of problems such as energy crisis and environmental pollution. Moisture-enabled electric generator (MEG) is a new type of energy conversion method, which can directly convert the ubiquitous moisture in the air into electrical energy equipment. It has attracted great interest for its renewable and environmentally friendly qualities. At present, most MEGs still have low power density, strong dependence on high humidity, and high cost. Herein, we report the development of a high-efficiency MEG with high power density, all-weather, and low cost using a simple strategy that optimizes the charge transport channel and ion concentration difference. The MEG devices we manufactured can generate the open-circuit voltage of 0.73V and the short-circuit current of 360μA, voltage can still reach 0.6V at less than 30% humidity. It is possible to drive commercial electronic devices such as light-emitting diodes, electronic displays, and electronic calculators by simply connecting several electric generators in series. Biomass-based moisture-enabled electric generation have low cost, is easy to integrate on a large scale, and is green and pollution-free, providing clean energy for low humidity or high electricity cost areas.
How do Adult-Child Caregivers Maintain Subjective Well-Being? The Reciprocal Suppression Effect from Caregiver Burden and Sense of Coherence
Authors: Ma Xinyue , Zheng Peiqi , Guo Ruiyuan , Du Mengqi , Ran Lingyun
Published: November 2023

Background: Adult children are primarily responsible for the older adults of the family in China. It remained in the question how caregiver burden not necessarily poses a threat on adult children’s subjective well-being. This study aimed to examine the interacting effect between caregiver burden and sense of coherence on maintaining subjective well-being among adult-child caregivers.
Methods: A total of 336 adult-child caregivers participated in this study. The Zarit Burden Interview (ZBI), Sense of Coherence scale (SOC-13), and Memorial University of Newfoundland Scale of Happiness (MUNSH) were used to measure participants’ caregiver burden, sense of coherence, and subjective well-being respectively.
Results: Results showed that when sense of coherence was included, the negative effect of caregiver burden on subjective well-being increased from - .279 to - .310. Likewise, when caregiver burden was included, the positive effect of sense of coherence on subjective well-being increased from .256 to .352. The analysis of hierarchical regression towards subjective well-being indicated that caregiver burden explained 15.1% of the variance (ΔR2 = .151, p < .01) while sense of coherence explained 5.6% (ΔR2 = .056, p < .01).
Conclusion: This study explored the reciprocal suppression effect between caregiver burden and sense of coherence to the maintenance of the subjective well-being of adult-child caregivers in China. According to this study, adult children who take on the role of caregiving can maintain adequate subjective well-being by strengthening their intrinsic psychological resource - sense of coherence.
Halo sign and reverse halo sign in a patient with primary lung adenocarcinoma; a case report
Authors: Ebrahimi Pouyan , Jamaati Hamidreza , Soleimani Amir Morteza
Published: November 2023

Introduction: The halo sign and reverse halo sign are two computerized tomography scan views based on the placement of ground glass opacity. These two views have various differential diagnoses, but infections are known to be the most important differential diagnosis in both views. Lung adenocarcinoma, one of the deadliest tumors of both genders, can be included in the differential diagnosis. Nevertheless, we decided to report this case since both of these features were present in the same patient.
Case presentation: He is a 51-year-old man who came to us with gradual symptoms such as shortness of breath and myalgia, with a history of smoking and coronavirus disease 2019, and in his computerized tomography scan, two views of halo sign and reverse halo sign were seen along with other lesions. In further investigations, due to his lack of recovery, a biopsy was prepared, and with a definitive diagnosis of lung adenocarcinoma, we treated the patient appropriately.
Conclusion: When a patient presents with halo sign and reverse halo sign on computerized tomography scan and smokes, it is necessary to take a biopsy of the observed lesions to rule out primary lung carcinoma.
Academic involution and mental internal friction of college students: the mediating role of academic stress and the moderating role of rumination
Authors: Liu Aichun , Wang Yi , Chen Zhaojun , Ni Jianchao
Published: November 2023

With the continuous development of society and the increasing intensity of competition, the issues of academic stress and mental internal friction among college students have become increasingly prominent. This phenomenon not only affects the physical and mental health of college students but also has profound implications for their academic performance and interpersonal relationships. This study aims to explore the relationships and underlying mechanisms between academic involution, mental internal friction, academic stress, and rumination. The research involved 626 college students and utilized the Academic Involution Scale, Mental Internal Friction Scale, Academic Stress Sources Scale, and Rumination Scale to collect data and establish a moderated mediation model. The results indicate that: (1) academic involution positively predicts mental internal friction; (2) academic stress plays a full mediating role in the relationship between academic involution and mental internal friction; (3) rumination moderates the pathway through which academic involution affects mental internal friction via academic stress. The study further illuminates the nature of understanding academic involution and mental internal friction issues in college students, providing theoretical support and practical guidance for higher education professionals in formulating effective intervention measures.
The Psychometric Property of the Thai Version of the Zuckerman–Kuhlman-Aluja Personality Questionnaire (ZKA-PQ)
Authors: Wongpakaran Tinakon , Wongpakaran Nahathai , Kövi Zsuzsanna
Published: November 2023

The Five-Factor Model of personality traits has consistently demonstrated expected associations with features of psychiatric disorders, both within the general population and clinical settings. In pursuit of a more nuanced understanding, facet-level assessments like the Zuckerman–Kuhlman–Aluja Personality Questionnaire (ZKA-PQ) offer deeper insights with their facets. However, it's noteworthy that the applicability of the ZKA-PQ to the Thai population remains untested. Our hypothesis centered on the idea that the ZKA-PQ would show anticipated correlations with perceived stress, depression, and neuroticism within the broader Thai population. Consequently, we enrolled 1382 participants from various backgrounds to partake in assessments, including the ZKA-PQ, the Perceived Stress Scale, the Core Symptom Index-Depression, and the Neuroticism Inventory. Our findings offered support for ZKA-PQ's overarching personality traits but not at the facet level. In alignment with observations in other non-Western cultures, it became evident that the Sensation Seeking and Activity facets exhibited sensitivity to the Thai population's dynamics. In light of these outcomes, further exploration to enhance the appropriateness of the Thai ZKA-PQ is merited. This pursuit could potentially illuminate cultural nuances that shape personality traits and their interplay within the Thai context.
Screening of aroma-producing performance of anticlostridial Lacticaseibacillus casei strains for use as adjunct cultures in cheesemaking
Authors: Renoldi Niccolò , Innocente Nadia , Rossi Anna , Brasca Milena , Morandi Stefano , Marino Marilena
Published: November 2023

The cheesemaking industry is increasingly interested in using adjunct cultures with potential aromatic and anticlostridial activities. In this study, 34 Lb. paracasei and 2 Lb. rhamnosus strains were isolated from a semi-hard cheese and characterized for their proteolytic, esterase, and anticlostridial activity. Moreover, the strains were inoculated in a curd-based medium and the volatile compounds in the headspace of samples were evaluated by SPME-GC-MS analysis. Proteolytic activity was present in 30 strains, whereas only one Lb. paracasei strain showed esterase activity. All strains inhibited Cl. sporogenes, Cl. beijerinckii, and Cl. butyricum, and 18 isolates inhibited at least one Cl. tyrobutyricum strain. Principal component analysis and clustering analysis based on the volatilome grouped strains into three groups. One of these groups was characterized by high amounts of acids and esters and clustered with control samples inoculated with commercial starter cultures, suggesting similarity in the aroma profile. Strains belonging to this group with inhibitory effects against Cl. tyrobutyricum might be exploited as autochthonous adjunct cultures for the reduction of late-blowing defects in semi-hard cheeses.
New Nighttime Dehazing Algorithm Based On Dark Channel Prior Enhancement
Authors: Ji Bin , Zheng Shuai , Chen Ze , Zhou Chuhao
Published: November 2023

Due to various sources of interference in nighttime haze scenes,the resulting dehazed images are generally dim and dull,with diffuse illumination sources and a poor signal-to-noise ratio when compared with daytime haze scenes.In this paper,we propose a new method for nighttime dehazing using dark channel prior(DCP) enhancement.Firstly,to mitigate the effects of highlight sources and pseudo-light source regions on ambient illumination estimation,a hybrid processing method is introduced combines side window box filtering and fast edge preserving filtering to pre-process nighttime haze images.The ambient illumination estimate of the image is derived based on the DCP theory.Secondly,the adaptive light source matrix mechanism is used to fuse and enhance the transmit-tance of light source and non-light source regions to further improve the initial transmittance problem of the image.After processing,the transmittance map is compensated by gamma correction for the light source.Finally,we replace the atmospheric scattering model to obtain a better dehazed image.The nighttime dehazing method was compared with other image dehazing methods,and significant improvements were found in both subjective and objective evaluations.The obtained images are more in line with the visual characteristics of human eyes,and the evaluation indexes such as PSNR,SSIM and NIQE have been improved.
A novel miR-490-3p/hnRNPA1-b/PKM2 axis intermediates the Warburg effect and proliferation of colon cancer via PI3K/AKT pathway
Authors: Wan Xianghui , Jin Guobing , Yang Qun , Hu Jilong , Liu Zhiliang , Rao Jun , Wen Can , Li Pengling , Yang Ximei , Huang Bo , Wang Xiaozhong
Published: November 2023

Background
Heterogeneous ribonucleoprotein A1 (hnRNPA1) has been reported to enhance Warburg effect and promote colon cancer (CC) proliferation, but the role and mechanism of miR-490-3p/hnRNPA1-b/PKM2 axis in CC are not yet elucidated.
Methods
Paraffin-embedded pathological sections from 220 colon cancer patients were collected and subjected to immunohistochemical analysis to determine the expression of hnRNPA1-b. The relationship between the expression values and the clinicopathological features of the patients was investigated. Differences in mRNA expression were analyzed using qPCR, while differences in protein expression were analyzed using Western blot. Cell proliferation was evaluated using CCK8 and EdU assays, and cell cycle and apoptosis were assessed using flow cytometric assays. The targeted binding of miR-490-3p to hnRNPA1-b was validated using a dual luciferase reporter assay. Warburg effect was evaluated through glucose uptake and lactic acid production assays.
Results
The expression of hnRNPA1-b was significantly increased in CC tissues and cells compared to normal controls (P < 0.05). Immunohistochemical results demonstrated significant variations in the expression of the hnRNPA1-b antigen among different stages of CC, including stage I, II-III, and IV. Furthermore, the clinicopathologic characterization revealed a significant correlation between hnRNPA1-b expression and clinical stage as well as T classification. HnRNPA1-b was found to enhance the Warburg effect through the PI3K/AKT pathway, thereby promoting proliferation of HCT116 and SW620 cells. However, the proliferation of HCT116 and SW620 cells was inhibited when miR-140-3p targeted and bound to hnRNPA1-b, effectively blocking the Warburg effect.
Conclusion
These findings suggest that the novel miR-490-3p/hnRNPA1-b/PKM2 axis could provide a new strategy for the diagnosis and treatment of CC.
A Series Representation of Analytically Continuous Complex Functions with Negative Powers
Authors: Hardy Devin
Published: November 2023

First a proof of Taylor’s Theorem is established by Integration by Parts, and then generalization of the IBPformula to ℂ is used to derive Taylor’s Theorem for Complex numbers 𝑧. A similar method to that which is used toderive Taylor’s Theorem is used to derive a Complex valued series representation similar to the Taylor Series but fornegative powers.
Assessment of the relationship between thyroid function and panic disorder: A mendelian randomization study
Authors: Yu Sijie , Shen Chongkai , Zhu Junpeng
Published: November 2023

Background
Multiple observational studies have indicated a correlation between thyroid function and the risk of panic disorder (PD). Nevertheless, the causality surrounding this association remains unclear. Our objective was to evaluate the causality between thyroid function and the risk of PD by employing Mendelian randomization (MR).
Methods
We employed publicly available genome-wide association studies (GWAS) to select single nucleotide polymorphisms (SNPs) that are associated with various aspects of thyroid function (hyperthyroidism, hypothyroidism, FT4, TSH, TPOAb, and thyroid nodules). The statistical data on panic disorder were obtained from the FinnGen consortium. To assess causality, we utilized the inverse variance weighted (IVW) method, MR-Egger method and weighted median (WM) method for the MR estimates. Sensitivity analyses were conducted using Cochran’s Q test, MR-Egger intercept, MR-Pleiotropy Residual Sum and Outlier method, leave-one-out analysis, and funnel plot.
Results
The genetically predicted presence of hyperthyroidism showed an inverse association with PD as evident from the IVW OR of 0.93 (95% CI: 0.87–0.98; P = 0.01).However, our findings did not indicate any causal effects of variation in FT4 (OR: 0.78, 95%CI: 0.78–1.27; P = 1)、TSH (OR: 1.03, 95%CI: 0.83–1.28; P = 0.77)、TPOAb (OR: 0.9, 95%CI: 0.47–1.72; P = 0.75)、hypothyroidism (OR: 0.57, 95%CI: 0.01–50.54; P = 0.81) and thyroid nodules (OR: 1.02, 95%CI: 0.91–1.14; P = 0.76) on PD risk.
Conclusions
In summary, Our findings indicated a significant inverse correlation between hyperthyroidism and PD risk, with no discernible causal impacts of alterations in FT4、TSH、TPOAb、hypothyroidism and thyroid nodules on PD risk. It may suggest that most thyroid function may not be the etiological factor of PD, further studies are needed to verify our results in the real world.
Sustaining our rural allied health workforce: Experiences and impacts of the allied health rural generalist pathway
Authors: Dymmott Alison , George Stacey , Campbell Narelle , Brebner Chris
Published: November 2023

Introduction: Rural and remote communities face significant disadvantages accessing health services and have a high risk of poor health outcomes. Workforce challenges in these areas are multifaceted, with allied health professionals requiring broad skills and knowledge to provide vital services to local communities. To develop the expertise for rural and remote practice, the allied health rural generalist pathway (AHRGP) was introduced to develop and recognise specialist skills and knowledge required for rural and remote practice, however the experiences of professionals has not been explored. This study gained the experiences and perceptions of allied health professionals undertaking the pathway as well as their clinical supervisors, line managers, profession leads and consumer representatives.
Methods: A qualitative study was undertaken drawing on pragmatic approaches across four research phases. This study was one component of a larger mixed methods study investigating the experience, impact and outcomes of the AHRGP across six regional Local Health Networks in South Australia. Interviews, surveys and focus groups were conducted to explore the perceptions and experiences of participants. Data was analysed thematically across participant groups and research phases.
Results: A total of 55 participants participated including 15 trainees, 13 line managers, nine clinical supervisors, six profession leads, four program managers and seven consumer representatives. Five themes emerged from the data; gaining broad skills and knowledge for rural practice, finding the time to manage the pathway, implementing learning into practice, the AHRGP impacts the whole team and confident, consistent, skilled allied health professionals positively impact consumers.
Conclusion: The AHRGP is offering allied health professionals the opportunity to develop skills and knowledge for rural and remote practice. It is also having positive impacts on individuals’ ability to manage complexity and solve problems. Findings indicated consumers and organisations benefited through the provision of more accessible, consistent, and high quality services provided by trainees. Trainees’ faced challenges finding the time to manage study and to implement learning into practice. Organisations would benefit from clearer support structures and resourcing to support the pathway into the future. Incentives and career advancement opportunities for graduates would strengthen the overall value of the AHRPG.
YOLOInvoiceWizard: Revolutionizing Invoice Generation through Object Detection
Authors: Teja G , Desu Sashank , Vamsikrishna Manne , Kumar Narendra , Siri Dharmapuri
Published: November 2023

This research paper introduces a novel approach to streamline the customer checkout process in retail stores through the integration of computer vision technology using YOLOv8 for object detection. The project's focus lies in facilitating efficient invoice generation by detecting products, identifying them accurately, and seamlessly adding them to a web-based graphical user interface (GUI) shopping cart. The proposed system aims to change the conventional billing procedure by leveraging computer vision capabilities to expedite the checkout process, minimizing customer wait times, and reducing human errors during billing. By harnessing the power of YOLOv8, a state-of-the-art object detection model, the system can identify various products placed on the counter. The detected items are added into a user-friendly web GUI cart that allows customers to conveniently track their selections while navigating the store. The integration of computer vision and web technology creates a unique and delightful customer experience during the checkout process, contributing to increased customer satisfaction and loyalty. The potential benefits of this project are multifaceted, encompassing reduced wait times at the billing counter, enhanced accuracy in billing processes, and overall improved efficiency in retail operations. The research paper concludes with a detailed evaluation of the prototype system's performance, validating its effectiveness in enhancing customer experiences and optimizing billing procedures in a real-world retail environment. This paper contributes to the advancement of computer vision applications in the retail sector, setting the stage for future innovations in customer-centric shopping experiences.