bluuebunny/crossref_metadata_2025 huggingface dataset:
Clonazepam as an Effective Treatment for Epilepsy in a Female Patient with NEXMIF Mutation: Case Report
Authors: Ogasawara Masashi , Nakagawa Eiji , Takeshita Eri , Hamanaka Kohei , Miyatake Satoko , Matsumoto Naomichi , Sasaki Masayuki
Published: September 2020

The NEXMIF (KIAA2022) gene is located in the X chromosome, and hemizygous mutations in NEXMIF cause X-linked intellectual disability in male patients. Female patients with heterozygous mutations in NEXMIF also show similar, but milder, intellectual disability. Most female patients demonstrate intractable epilepsy compared with male patients, and the treatment strategy for epilepsy is still uncertain. Thus far, 24 female patients with NEXMIF mutations have been reported. Of these 24 patients, 20 also have epilepsy. Until now, epilepsy has been controlled in only 2 of these female patients. We report a female patient with a heterozygous de novo mutation, NM_001008537.2:c.1123del (p.Glu375Argfs*21), in NEXMIF. The patient showed mild intellectual disability, facial dysmorphism, obesity, generalized tonic-clonic seizures, and nonconvulsive status epilepticus. Sodium valproate was effective but caused secondary amenorrhea. We successfully treated her epilepsy with clonazepam without side effects, indicating that clonazepam might be a good choice to treat epilepsy in patients with NEXMIF mutations.
Impacts of COVID-19 on Liver Cancers: During and after the Pandemic
Authors: Chan Stephen Lam , Kudo Masatoshi
Published: September 2020

Background: The pandemic of coronavirus disease 2019 (COVID-19) has diverted resources from healthcare services for patients with chronic medical illness such as cancer. COVID-19 also causes organ dysfunction, complicating cancer treatment. In most countries with an outbreak of COVID-19, modifications of cancer management have been adopted to accommodate the crisis and minimize the exposure of cancer patients to the infection. In countries where COVID-19 numbers are subsiding, medical teams should also be prepared to resume normal practices gradually. Here, we aim to review the literature on the impact of COVID-19 on patients with hepatocellular carcinoma (HCC) as well as discuss modifications to the management of HCC during and after recovery from the pandemic. Summary: Based on current data, 10–40% of patients with COVID-19 have hepatic injury characterized by an elevation of transaminases and/or hyperbilirubinemia. Multiple mechanisms contribute to the hepatic injury, including direct viral entry to hepatocytes/cholangiocytes, immune-mediated hepatitis, hypoxia, and drug-related hepatotoxicity. In patients with HCC, COVID-19 may exacerbate existing chronic liver disease and complicate the management of cancer. Cancer patients generally have a higher risk of infection and worse outcome, especially those who have recently undergone cancer treatment. Although HCC is under-represented in COVID-19 series, mitigation measures should be implemented to minimize the exposure of patients to the virus. A decision on the treatment of HCC should be balanced with consideration of the availability of medical resources, the level of infection risk of COVID-19, and the risk-benefit ratio of the individual patient. In areas where the COVID-19 outbreak is subsiding, clinicians should be prepared to manage a surge of HCC patients with higher disease burdens and complications. Key Messages: Mitigation measures to protect at-risk patients, such as those with cancers, from SARS-CoV-2 infection should be exercised and the impact of COVID-19 on this group of patients should be thoroughly studied.
Privacidade, sigilo e compartilhamento
Authors:   Universidade de São Paulo. Escola de Comunicações e Artes, Costa Cristina
Published: September 2020

Tratando das questões tecnológicas, legais, políticas, sociais e comunicacionais que envolvem o tema, essa obra atualizará os argumentos que a séculos são apresentados em defesa de um bem e um direito que tem se tornado a cada dia mais importante – a liberdade de pensar, expressar e debater posições político-ideológicas através da produção cultural, informacional ou artística.
“À moda de”
Authors: Pinheiro Valter Cesar
Published: September 2020

Em 1918 Sérgio Milliet lançou, com Charles Reber, En singeant...: pastiches littéraires, segundo livro de sua lavra em solo suíço (um ano antes, saíra Par le sentier pela editora Le Carmel). O autor publicaria mais duas obras antes de retornar ao Brasil: Le départ sous la pluie e Œil de bœuf. O objetivo deste estudo é, à luz das reflexões sobre o pastiche propostas por Genette, Decout e Aron, apresentar – passando em revista o contexto de publicação e o rol de homenageados com as imitações – comentários acerca de um título que permanece desconhecido dos leitores e ignorado pela crítica.
Purinergic Dysfunction in Pulmonary Arterial Hypertension
Authors: Cai Zongye , Tu Ly , Guignabert Christophe , Merkus Daphne , Zhou Zhichao
Published: September 2020

Pulmonary arterial hypertension (PAH) is a life‐threatening disease characterized by increased pulmonary arterial pressure and pulmonary vascular resistance, which result in an increase in afterload imposed onto the right ventricle, leading to right heart failure. Current therapies are incapable of reversing the disease progression. Thus, the identification of novel and potential therapeutic targets is urgently needed. An alteration of nucleotide‐ and nucleoside‐activated purinergic signaling has been proposed as a potential contributor in the pathogenesis of PAH. Adenosine‐mediated purinergic 1 receptor activation, particularly A2AR activation, reduces pulmonary vascular resistance and attenuates pulmonary vascular remodeling and right ventricle hypertrophy, thereby exerting a protective effect. Conversely, A2BR activation induces pulmonary vascular remodeling, and is therefore deleterious. ATP‐mediated P2X7R activation and ADP‐mediated activation of P2Y1R and P2Y12R play a role in pulmonary vascular tone, vascular remodeling, and inflammation in PAH. Recent studies have revealed a role of ectonucleotidase nucleoside triphosphate diphosphohydrolase, that degrades ATP/ADP, in regulation of pulmonary vascular remodeling. Interestingly, existing evidence that adenosine activates erythrocyte A2BR signaling, counteracting hypoxia‐induced pulmonary injury, and that ATP release is impaired in erythrocyte in PAH implies erythrocyte dysfunction as an important trigger to affect purinergic signaling for pathogenesis of PAH. The present review focuses on current knowledge on alteration of nucleot(s)ide‐mediated purinergic signaling as a potential disease mechanism underlying the development of PAH.
Association Between the Onset Pattern of Adult Moyamoya Disease and Risk Factors for Stroke
Authors: Hirano Yudai , Miyawaki Satoru , Imai Hideaki , Hongo Hiroki , Ohara Kenta , Dofuku Shogo , Teranishi Yu , Nakatomi Hirofumi , Saito Nobuhito
Published: September 2020

Background and Purpose:

Few previous studies have comprehensively explored the relationship between the onset pattern of adult moyamoya disease and risk factors for stroke. We performed a retrospective analysis focusing on risk factors for stroke and related findings on magnetic resonance imaging/angiography with respect to the pattern of disease onset. We also examined whether risk factors for stroke were associated with an increased risk for symptomization in asymptomatic patients.

Methods:

A total of 178 adult patients with moyamoya disease (asymptomatic, n=84; ischemic, n=71; hemorrhagic, n=23) at the University of Tokyo Hospital from 2000 to 2018 were included in this study. Data pertaining to patient background and magnetic resonance imaging findings were analyzed retrospectively. In the asymptomatic group, the effects of stroke-associated risk factors on symptom onset were analyzed.

Results:

Comparisons among the 3 groups revealed no significant difference in the frequency of risk factors for stroke. The proportion of patients with magnetic resonance imaging/angiography findings indicating anterior choroidal artery anastomosis or microbleeds was significantly higher in the hemorrhagic group than in the asymptomatic or ischemic group. Among asymptomatic patients, the hazard ratios for symptomization with hypertension and dyslipidemia were 6.69 ([95% CI, 1.23–36.4]
P
=0.028) and 8.14 ([95% CI, 1.46–45.2]
P
=0.017), respectively.

Conclusions:

The development of anterior choroidal artery anastomosis and microbleeds on magnetic resonance imaging/angiography was significantly associated with hemorrhagic onset. Hypertension and dyslipidemia may increase the risk of cerebrovascular events in asymptomatic patients, and thus, early intervention to these factors may be important.
Mexican American Immigrants Demonstrate Better Functional Stroke Outcomes Compared With Mexican American Nonimmigrants
Authors: Hollenhorst Cecilia N. , Gibbs River , Kim Sehee , Agyemang Charles , Lisabeth Lynda , Morgenstern Lewis B.
Published: September 2020

Background and Purpose:

We analyzed differences in 90-day poststroke outcomes between Mexican Americans born in the United States (nonimmigrant) compared with those born outside the United States (immigrant).

Methods:

We performed a retrospective analysis of prospective data from the population-based Brain Attack Surveillance in Corpus Christi project. We identified stroke cases from 2008 to 2016 and quantified functional, cognitive, and neurological outcomes. Associations between outcome scores and immigration status were analyzed using weighted linear regression models.

Results:

Eighty-three Mexican American stroke cases (n=935) were immigrants, and 852 stroke cases were nonimmigrants. Average length of stay in the United States for immigrants was 47 years. Immigrants were older (69 versus 66 years), more likely men (60% versus 49%), had less education on average, and were more likely to have atrial fibrillation compared with nonimmigrants. No differences in other comorbidities existed between groups. After adjustment for confounders, immigrants had better functional outcomes (activities of daily living/instrumental activities of daily living; mean difference, −0.22;
P
=0.02; 1–4, higher scores worse) and no difference in neurological outcomes (log-National Institutes of Health Stroke Scale; mean difference, −0.15;
P
=0.15; 0–44, higher scores worse) or cognitive outcomes (3 Mini-Mental State Examination; mean difference, −0.79;
P
=0.64; 0–100, lower scores worse).

Conclusions:

Long-term Mexican American immigrants in this community display better stroke functional outcomes than nonimmigrant Mexican Americans and comparable neurological and cognitive outcomes.
A new limestone-dwelling leaf-toed gecko (Gekkonidae: Dixonius) from coastal hills in Cha-am, peninsular Thailand
Authors: PAUWELS OLIVIER S. G. , CHOMNGAM NIRUT , LARSEN HENNING , SUMONTHA MONTRI
Published: September 2020

We describe Dixonius pawangkhananti sp. nov. from coastal limestone hills in Cha-am District, Phetchaburi Province, peninsular Thailand. The new species differs from all currently recognized Dixonius by the following combination of morphological characters and pattern: maximal known snout-vent length of 42.6 mm; 16 longitudinal rows of dorsal tubercles; 30 to 32 paravertebral scales; 16 longitudinal rows of ventral scales across the abdomen; six precloacal pores in males, no pores in females; a marked canthal stripe; and a sexually dimorphic dorsal pattern consisting of bands (males) or blotches (females). This description brings the number of Dixonius species to ten, with four species endemic to Thailand.
Effects of Wave Streaming and Wave Variations on Nearshore Wave-Driven Circulation
Authors: Wang Peng , McWilliams James C. , Uchiyama Yusuke , Chekroun Mickaël D. , Yi Daling Li
Published: September 2020

Wave streaming is a near-bottom mean current induced by the bottom drag on surface gravity waves. Wave variations include the variations in wave heights, periods, and directions. Here we use numerical simulations to study the effects of wave streaming and wave variations on the circulation that is driven by incident surface waves. Wave streaming induces an inner-shelf Lagrangian overturning circulation, which links the inner shelf with the surf zone. Wave variations cause alongshore-variable wave breaking that produces surf eddies; however, such eddies can be suppressed by wave streaming. Moreover, with passive tracers we show that wave streaming and wave variations together enhance the cross-shelf material transport.
Meta-Analysis on the Effect of Pasireotide for Prevention of Postoperative Pancreatic Fistula
Authors: Dalton Elissa C. , Johns Michael S. , Rhodes Lori , Merritt William T. , Petrelli Nicholas J. , Tiesi Gregory J.
Published: September 2020

Background

A randomized controlled trial of routine administration of pasireotide demonstrated decreased incidence of clinically significant postoperative pancreatic fistula (POPF). Recent studies have not replicated these results. A meta-analysis was performed to evaluate its efficacy in this setting.

Methods

Prospective trials utilizing pasireotide prophylactically after pancreatectomy were reviewed. The primary outcome was clinically significant POPF. Secondary outcomes included length of stay (LOS), readmission rates, and mortality. Study heterogeneity was assessed.

Results

Five studies totaling 1571 patients were identified. There was no difference in age, sex, or cancer rates. Pasireotide patients had smaller pancreatic ducts ( P < .001) and softer glands ( P = .04). For all pancreatectomies, there was no difference in POPF rates (odds ratio [OR] 0.84; 95% CI 0.60-1.16, P = .29). Patients undergoing distal pancreatectomy (OR 0.70; 95% CI 0.30-1.63, P = .41) had similar rates of POPF versus pancreaticoduodenectomy (PD) patients who experienced a lower incidence of POPF (OR 0.60; 95% CI 0.42-0.86, P = .006). Mortality rates and LOS were similar. Readmission rates were decreased with pasireotide (OR 0.61; 95% CI 0.44-0.85).

Conclusions

Routine administration of pasireotide did not decrease POPF rates for all pancreatectomies, but was associated with lower rates for PD, and decreased readmission rates. Further prospective, randomized studies are warranted.
Blurring the Lines between Physical and Digital Spaces: Business Model Innovation in Retailing
Authors: Jocevski Milan
Published: September 2020

Traditional retail practices are under stress as retailers ponder various ways of setting up a sustainable omnichannel business model. A significant challenge in their endeavor relates to the blurring lines between physical and digital worlds. This article analyzes three retailers’ exploratory efforts of alternative physical retail spaces. There are five key innovation areas to revamp for such a retail store: in-store technology, the role of sales associates, leveraging a mobile channel, data analytics, and collaborations. Moreover, physical retail space can serve as an aggregation hub that connects various retailer-customer interaction points across physical and digital spaces.
Tracking control via sliding mode for heavy-haul trains with input saturation
Authors: He Jing , Yang Xingxing , Zhang Changfan , Liu Jianhua , Zhang Qian , Chen Xueyuan
Published: September 2020

To address the tracking control problem of heavy-haul trains (HHTs) with input saturation during operation, an anti-saturation sliding mode (SMES) control method based on dynamic auxiliary compensator (DAC) is presented. Firstly, an HHT model with nonlinear coupling and uncertain disturbances is built. Secondly, a new type of DAC is introduced to overcome the difficulty of traditional dynamic auxiliary compensator (TDAC) with a large upper bound on the compensation signal. Finally, an anti-saturation SMES control algorithm is designed to reduce the influence of input saturation on the tracking accuracy of each carriage. Simulation results verify the effectiveness of the algorithm in terms of tracking accuracy, anti-interference, and anti-saturation.
Investigation of the fatigue behavior of thermoplastic composites by load increase tests
Authors: Baumann Andreas , Backe Sebastian , Hausmann Joachim
Published: September 2020

Fatigue is one major load case in many structures for transport applications. New materials often lack the necessary data base for a fast application in cyclic loaded components due to time consuming testing series. The aim of this study is the evaluation of the load increase test as method to determine a possible fatigue limit of glass fiber reinforced polyamide 6. Under the working hypothesis that cracks are the main contributors for heat emission, the results show that the investigated material exhibits a different behavior in comparison to thermosets. Instead of crack formation experimental and numerical data indicate that the matrix relaxes under fatigue loading. This relaxation could potentially lead to crack prevention but might also result in the observed sudden failure behavior of the material. These findings suggest a totally different behavior of thermoplastic composites under fatigue loading.
Impostor Feelings of Music Education Graduate Students
Authors: Sims Wendy L. , Cassidy Jane W.
Published: September 2020

Impostor phenomenon (IP) is the psychological construct used to describe potentially debilitating feelings of fraud and fear of being exposed as a phony in individuals who are actually high achieving and successful. The purpose of this study was to investigate the IP feelings of music education graduate students. A total of 130 master’s and doctoral students completed a survey that included the Clance IP Scale, the Graduate Music Student Scale, and demographic items. Results indicated that impostor feelings were present in a substantial percentage of the participants. Full-time student status was associated with stronger IP responses than part-time status, as was working on the degree face-to-face versus hybrid. More frequent and intense impostor feelings were experienced by females versus males, participants ages 26 to 35, students who were not married or in a committed relationship, and those who were the first in their family to attend graduate school. Master’s and doctoral students’ IP responses were not different, but successive year in the graduate program was associated with stronger impostor feelings. Based on the possible detrimental effects of strong impostor feelings, the findings should raise concern for students, their instructors, and their mentors.
Psychometric Analysis of the Turkish Brief Hospitality Scale
Authors: Yıldırım Murat , Güler Abdurrahim
Published: September 2020

Brief Hospitality Scale (BHS) is a short self-reported instrument for measuring hospitality at the global level. The aim of this study was to examine for the first time the psychometric properties of the BHS in three Turkish-speaking samples (Sample 1, n = 139, mean age = 20.68 ± 1.68 years; Sample 2, n = 160, mean age = 22.10 ± 3.35 years; Sample 3, n = 105, mean age = 31.67 ± 7.51 years). Participants completed measures of hospitality, life satisfaction, and personality traits. Our results showed that the Turkish version of the BHS has excellent levels of internal consistency reliability. The exploratory and confirmatory factor analyses indicated that a one-factor solution of the BHS had a good model fit. Additionally, the scale had acceptable criterion-related validity in relation to satisfaction with life and personality traits. Furthermore, the BHS contributed additional variance to the prediction of satisfaction with life over and above the personality traits. There were no gender and socioeconomic status differences in the hospitality scores across the studies. The Turkish BHS is a promising scale that should be used preferably for exploratory purposes in research and practice.
Changing Climatic Conditions and Agricultural Livelihoods: An Impact Study in Jagatsinghpur District, Odisha
Authors: Moharaj Prasanta , Rout Satyapriya
Published: September 2020

This article attempts to examine the negative impact of climate change on agricultural livelihood and human social life. Natural climatic variations have always been a challenge for human sustenance as they are predicated on a host of factors that include natural, human-made and unbalanced environmental conditions. India too, with its geographic zones such as mountains, small islands, wetlands, coastal areas, deserts, semi-arid lands and plains is exposed to challenges of climatic change. The impact of climate is particularly severe on the livelihoods of the rural poor. For instance, people living near coastal regions are constantly prone to severe floods. This study specifically focusses on coastal Odisha and the impact of floods which have been triggered by climate change. The study, looking at the effect on crop production and socio-economic conditions, has followed a two-pronged approach––conducting a field survey and collecting data from secondary sources.
Use of artificial intelligence in computed tomography dose optimisation
Authors: McCollough C.H. , Leng S.
Published: September 2020

The field of artificial intelligence (AI) is transforming almost every aspect of modern society, including medical imaging. In computed tomography (CT), AI holds the promise of enabling further reductions in patient radiation dose through automation and optimisation of data acquisition processes, including patient positioning and acquisition parameter settings. Subsequent to data collection, optimisation of image reconstruction parameters, advanced reconstruction algorithms, and image denoising methods improve several aspects of image quality, especially in reducing image noise and enabling the use of lower radiation doses for data acquisition. Finally, AI-based methods to automatically segment organs or detect and characterise pathology have been translated out of the research environment and into clinical practice to bring automation, increased sensitivity, and new clinical applications to patient care, ultimately increasing the benefit to the patient from medically justified CT examinations. In summary, since the introduction of CT, a large number of technical advances have enabled increased clinical benefit and decreased patient risk, not only by reducing radiation dose, but also by reducing the likelihood of errors in the performance and interpretation of medically justified CT examinations.
‘To reforme a frame’: The 1602 translation of Il pastor fido and Elizabethan theatrical publishing
Authors: Morini Massimiliano
Published: September 2020

In the history of translation, it is often the case that one version of a popular book becomes so well-known that it tends to eclipse the efforts of all previous and subsequent practitioners. Richard Fanshawe’s 1647 translation of Giovanni Battista Guarini’s pastoral play, Il pastor fido, has led scholars to overlook the virtues of an earlier version, attributed to Tailboys Dymock and published in 1602. This article argues that this edition, and the book that introduced it to late-Elizabethan London, should be regarded as an important document in the development of English dramatic language and English theatrical publishing.
Shared Decision Making for Surgical Care in the Era of COVID‐19
Authors: Forner David , Noel Christopher W. , Densmore Ryan , Goldstein David P. , Corsten Martin , Pieterse Arwen H. , Shuman Andrew G. , Hong Paul , Rac Valeria E.
Published: September 2020

The global pandemic caused by severe acute respiratory syndrome coronavirus 2 has upended surgical practice. In an effort to preserve resources, mitigate risk, and maintain health system capacity, nonurgent surgeries have been deferred in many jurisdictions, with urgent procedures facing increasing wait times and unpredictability given potential future surges. Shared decision making, a process that integrates patient values and preferences with the scientific expertise of clinicians, may be of particular benefit during these unprecedented times. Aligning patient choices with their values, reducing unnecessary health care use, and promoting consistency between providers are now more critical than ever before. We review important aspects of shared decision making and provide guidance for its perioperative application during the coronavirus disease 2019 pandemic.
Recruitment and Networking With Social Media for the Otolaryngology Match in the COVID‐19 Pandemic
Authors: Mecham Jeffrey C. , Menapace Deanna C. , Bowe Sarah N. , Carlson Matthew L.
Published: September 2020

COVID‐19 has created new challenges and opportunities regarding the way in which programs and applicants will interact in the 2020‐2021 otolaryngology residency match cycle. Social media and other virtual platforms offer a flexible and efficient medium for applicants and programs to gain information, communicate, and align interests. In this commentary, we explore ways in which social media may facilitate recruitment and networking in the virtual otolaryngology match.
Food choices and Social distinctions among University Students in Hyderabad
Authors: Gundemeda Nagaraju
Published: September 2020

Based on empirical study, designed to capture the views of students in a leading Indian university on diverse types of dietary choices, this article specifically examines the extent of acceptability of beef and pork in hostel menus. The study found that while only widely accepted vegetarian and non-vegetarian food items like chicken and mutton featured in mess menus, the scale of social tolerance for beef and pork consumption among students is actually much larger, and much more widely spread than hegemonic mainstream claims have been ready to admit. Based on such findings, this sociological study raises wider implications regarding the politics of food choice in India today.
Bhutan’s Dream City of Thimphu
Authors: Khamrang Leishipem
Published: September 2020

Buttressed by the philosophy of Gross National Happiness (GNH), Bhutan’s development policies are inherently grounded in balancing material and spiritual well-being, while Bhutan’s capital city, Thimphu, has over the past few decades experienced phenomenal growth and urban transformation. This article builds on the notion of socio-spatial dialectic to examine the new forms of social ordering in the urban space of Thimphu. Critiquing the idealisation of Thimphu as a dream city for all, it endorses instead the development of regional growth centres and small towns. This underlines the potential of stimulating regional economic development, as a better strategy for inclusive growth and actualisation of Bhutan’s philosophy of GNH.
Deras Beyond Caste: Remedies for Developmental Pressures
Authors: Rathi Ankita
Published: September 2020

In the northern regions of India, the rising popularity of alternative religious sects, prominently Deras, has sparked much interest in explaining this phenomenon. Current literature, based on case studies of specific Dalit Deras, relates the emergence of these religious sects to caste-based social discrimination and exclusion of lower castes by the mainstream Sikh religion. This article presents a case study of a small town, Patran, in the state of Punjab. Confirming the popularity of these alternative religious sects for upper and lower castes in the town, the article argues that the contemporary attractiveness of Deras needs to be understood also as a result of localised agrarian dynamics and related social pressures engendered by the process of rural to urban and agrarian to non-agrarian transition.
“Exceeding Beringia”: Upending universal human events and wayward transits in Arctic spaces
Authors: Smith Jen Rose
Published: September 2020

In this article I examine the enlistment of Arctic ice to tell grand, universal stories about humanity’s origins and endings. Specifically, I analyze 18th century Natural History musings that linked Arctic climate to race and human difference. I demonstrate that these musings are constitutive to an invention of pathologized migrancy across Arctic spaces that emerge as a consequence of the inability of ice to foster agricultural settlement. I call this phenomenon temperate-normativity, in which Arctic spaces of ice are produced as inferior, not meaningful on their own but read as where transit to temperate locales occurs and those who linger are consequentially rendered as aberrant. To upend temperate-normative ideals of landscape and livelihood, I analyze a poem titled “Exceeding Beringia” by Joan Naviyuk Kane (Inupiaq) wherein Inupiaq relations to more-than-human kin articulate transit and migration as a mutual, obligatory responsibility.
Avoidant attachment and own and perceived partner’s conflict resolution in relationship satisfaction
Authors: Bretaña Ione , Alonso-Arbiol Itziar , Molero Fernando , Pardo Juan
Published: September 2020

The aim of this study was to analyze the effect of conflict resolution strategies in the links between the avoidant attachment dimension and relationship satisfaction. The sample comprised 274 participants (ranging from 18 to 73 years old, 58% women). A predictive model of relationship satisfaction was tested, taking into account avoidant attachment and both own and perceived partner’s conflict resolution strategies. Structural equation modeling was used. Fit indexes indicated that the suggested overall relationship model was confirmed. Own withdrawal conflict resolution was associated positively with individuals’ perception of partner demand. Specifically, there was an indirect effect between own withdrawal and relationship satisfaction mediated by demand strategy perceived in the partner. Own withdrawal was negatively associated with perceived partner’s problem solving, and perceived partner’s positive conflict resolution strategy was positively associated with relationship satisfaction. Practical implications for professionals working with couples are discussed.
Linguistic and temporal resources of pre-stored utterances in everyday conversations
Authors: Savolainen Irina , Klippi Anu , Tykkyläinen Tuula , Launonen Kaisa
Published: September 2020

Aided communicators often have an opportunity to express themselves with speech-generating devices (SGDs) that produce symbol by symbol (SBS) and/or pre-stored (PS) utterances. Studies on the usage of PS utterances report that these utterances affect conversations positively, but it appears that aided communicators and professionals may have divergent views on their benefits. The aim of this study is to analyse how school-aged aided communicators, their mothers, peers, and speech and language therapists (SLTs) co-construct the social actions of PS utterances during their everyday interactions. The theoretical framework of this study is conversation analysis. This approach to analysing the data enhances our understanding of the linguistic and temporal resources of PS utterances and how they are used to reinforce various rich social actions that promote the progress of aided conversations to resemble natural spoken conversations. The results of this study will help SLTs and teachers in their planning content for SGDs as well as in teaching, and guiding aided communicators and their partners to utilize PS utterances in combination with SBS utterances during their conversations.
The role of MRI texture analysis based on susceptibility-weighted imaging in predicting Fuhrman grade of clear cell renal cell carcinoma
Authors: Sun Jun , Pan Liang , Zha Tingting , Xing Wei , Chen Jie , Duan Shaofeng
Published: September 2020

Background

The Fuhrman nuclear grade system is one of the most important independent indicators in patients with clear cell renal cell carcinoma (ccRCC) for aggressiveness and prognosis. Preoperative assessment of tumor aggressiveness is important for surgical decision-making.

Purpose

To explore the role of magnetic resonance imaging (MRI) texture analysis based on susceptibility-weighted imaging (SWI) in predicting Fuhrman grade of ccRCC.

Material and Methods

A total of 45 patients with SWI and surgically proven ccRCC were divided into two groups: the low-grade group (Fuhrman I/II, n = 29) and the high-grade group (Fuhrman III/IV, n = 16). Texture features were extracted from SWI images. Feature selection was performed, and multivariable logistic regression analysis was performed to develop the SWI-based texture model for grading ccRCCs. Receiver operating characteristic (ROC) curve analysis and leave-group-out cross-validation (LGOCV) were performed to test the reliability of the model.

Results

A total of 396 SWI-based texture features were extracted from each SWI image. The SWI-based texture model developed by multivariable logistic regression analysis was: SWIscore = –0.59 + 1.60 * ZonePercentage. The area under the ROC curve of the SWI-based texture model for differentiating high-grade ccRCC from low-grade ccRCC was 0.81 (95% confidence interval 0.67–0.94), with 80% accuracy, 56.25% sensitivity, and 93.10% specificity. After 100 LGOCVs, the mean accuracy, sensitivity, and specificity were 90.91%, 91.83%, and 89.89% for the training sets, and 77.29%, 80.52%, and 71.44% for the test sets, respectively.

Conclusion

SWI-based texture analysis might be a reliable quantitative approach for differentiating high-grade ccRCC from low-grade ccRCC.
Usefulness of pointwise encoding time reduction with radial acquisition sequence in subtraction-based magnetic resonance angiography for follow-up of the Neuroform Atlas stent-assisted coil embolization for cerebral aneurysms
Authors: Heo Young Jin , Jeong Hae Woong , Kim Donghyun , Baek Jin Wook , Han Ji-yeon , Choo Hye Jung , Kim Sung Tae , Jeong Young Gyun , Jin Sung-Chul
Published: September 2020

Background

Although time-of-flight magnetic resonance angiography (TOF-MRA) is widely used, it has limited usefulness for follow-up after stent-assisted coil embolization. Contrast-enhanced MRA (CE-MRA) and ultrashort echo time MRA have been suggested as alternative methods for visualization after this procedure.

Purpose

To compare efficacy and usefulness of pointwise encoding time reduction with radial acquisition (PETRA) sequence in subtraction-based MRA (qMRA), TOF-MRA, and CE-MRA during the follow-up after Neuroform Atlas stent-assisted coil embolization for intracranial aneurysms.

Material and Methods

This retrospective study included 23 patients with 24 aneurysms who underwent Neuroform Atlas stent-assisted coil embolization for intracranial aneurysms. All patients were evaluated with PETRA qMRA, TOF-MRA, and CE-MRA at the same follow-up session. The flow within stents, occlusion status, and presence of pseudo-stenosis were evaluated; inter-observer and intermodality agreements for the three methods were also graded.

Results

The mean score for flow visualization within the stents was significantly higher for PETRA qMRA and CE-MRA than for TOF-MRA (although no significant difference was found between PETRA qMRA and CE-MRA). Good inter-observer agreement was observed for each modality. PETRA qMRA and CE-MRA were more consistent with digital subtraction angiography (DSA) than TOF-MRA for aneurysm occlusion status. The intermodality agreement was better between PETRA qMRA and DSA, and between CE-MRA and DSA, than between DSA and TOF-MRA. Pseudo-stenosis was most frequently observed in TOF-MRA, followed by CE-MRA and PETRA qMRA.

Conclusion

PETRA qMRA is useful for evaluating the parent artery patency and occlusion status of aneurysms after Neuroform Atlas stent-assisted coil embolization.
The relevance of ecoregions and mountainous environments in the diversity and endemism of land gastropods
Authors: Dos Santos DA , Domínguez E , Miranda MJ , Gregoric DE Gutiérrez , Cuezzo MG
Published: September 2020

Twenty-five sub-ecoregions make Argentina from southern South America a favored area to study the mutual correspondence between environments and biodiversity. Unfortunately, efforts devoted to study these environments are unbalanced, with the subtropical dry forests less studied than the tropical and subtropical humid ones. Since the limits of ecoregions are based on vegetation criteria, land gastropods represent an independent source of information to test the relevance of sub-ecoregions in different aspects of biodiversity. We ask if land gastropods mirror these traditional diversity patterns when their distributions are framed in the context of sub-ecoregions. Additionally, we want to test if short-range endemic species (SRE) are randomly scattered across the sub-ecoregions. We first built an updated taxonomic checklist and mapped all the valid records compiled to date. Taxonomic richness, taxonomic diversity, and beta-diversity between sub-ecoregions were calculated. We obtained a hierarchical grouping of sub-ecoregions and the respective list of species that significantly support each cluster. We also developed two new analytical resources: a radial plot for showing the species composition of clusters resolved at three taxonomic levels, and a mixed coefficient of distributional size useful to identify SRE from sparse point records. This dimensionless measure of spatial range combines information of both the convex hull area and the length of the minimum spanning tree connecting point localities of presence. The Southern Andean Yungas and Dry Chaco are the species-level richest ecoregions. Although the Paranaense Forest harbors half of the number of species found in the Chaco Serrano, it reaches the highest score of taxonomic diversity because of the eclectic nature of their genera. SRE species are not randomly distributed across the sub-ecoregions, but they broadly overlap with the orographic Peripampasic arc extended over Chaco Serrano and Yungas Forests. SREs are highly dependent on the physical nature of the landscape.
Reason to doubt the ICHD-3 7-day inclusion criterion for mild TBI-related posttraumatic headache: A nested cohort study
Authors: McGeary Donald D , Resick Patricia A , Penzien Donald B , Eapen Blessen C , Jaramillo Carlos , McGeary Cindy A , Nabity Paul S , Peterson Alan L , Young-McCaughan Stacey , Keane Terence M , Reed David , Moring John , Sico Jason J , Pangarkar Sanjog S , Houle Timothy T ,   the Consortium to Alleviate PTSD
Published: September 2020

Background

Posttraumatic headache is difficult to define and there is debate about the specificity of the 7-day headache onset criterion in the current definition. There is limited evidence available to guide decision making about this criterion.

Method

A nested cohort study of 193 treatment-seeking veterans who met criteria for persistent headache attributed to mild traumatic injury to the head, including some veterans with delayed headache onset up to 90 days post-injury, was undertaken. Survival analysis examined the proportion of participants reporting headache over time and differences in these proportions based on sex, headache phenotype, and mechanism of injury.

Result

127 participants (66%; 95% CI: 59–72%) reported headache onset within 7 days of head injury and 65 (34%) reported headache onset between 8 days and 3 months after head injury. Fourteen percent of participants reported pre-existing migraine before head injury, and there was no difference in the proportion of veterans with pre-existing migraine based on headache onset. Headache onset times were not associated with sex, headache phenotype, or mechanism of injury. There were no significant differences in proportion of veterans with headache onset within 7 days of head injury based on headache phenotype (70% migraine onset within 7 days, 70% tension-type headache within 7 days, 56% cluster headache within 7 days; p ≥ .364). Similar findings were observed for head injury (64% blast, 60% blunt; p = .973). There were no significant differences observed between headache onset groups for psychiatric symptoms (Posttraumatic Stress Disorder Checklist for DSM-5 = 1.3, 95% CI = −27.5, 30.1; Patient Health Questionnaire-9 Item = 3.5, 95% CI = −6.3, 3.7; Generalized Anxiety Disorder Screener = 6.5, 95% CI = −2.7, 15.6).

Conclusions

Although most of the sample reported headache onset within 7 days of head injury, one-third experienced an onset outside of the diagnostic range. Additionally, veterans with headache onset within 7 days of head injury were not meaningfully different from those with later onset based on sex, headache phenotype, or mechanism of head injury. The ICHD-3 diagnostic criteria for 7-day headache onset should be expanded to 3 months.

ClinicalTrials.gov Identifier

NCT02419131
Measurement Invariance of the Wechsler Intelligence Scale for Children, Fifth Edition 10-Subtest Primary Battery: Can Index Scores be Compared across Age, Sex, and Diagnostic Groups?
Authors: Dombrowski Stefan C. , Watkins Marley W. , McGill Ryan J. , Canivez Gary L. , Holingue Calliope , Pritchard Alison E. , Jacobson Lisa A.
Published: September 2020

Measurement invariance of the Wechsler Intelligence Scale for Children, Fifth Edition (WISC-V) 10 subtest primary battery was evaluated across sex, age (6–8, 9–11, 12–14, and 15–16 year-olds), and three diagnostic (attention-deficit/hyperactivity disorder, anxiety, and encephalopathy) groups within a large clinical sample ( N = 5359) referred to a children’s specialty hospital. Competing models were tested using confirmatory factor analysis (CFA), and a five-factor oblique model corresponding to the publisher’s hypothesized first-order measurement model (e.g., verbal comprehension, fluid reasoning, visual-spatial, working memory, and processing speed) was found to have the best model fit. Multigroup CFA was subsequently used to evaluate progressively more restrictive constraints on the measurement model. Results indicated that full metric invariance was attained across the three groups studied. Full scalar invariance was attained for sex and diagnostic groups. Partial scalar invariance was attained for age-group. The results of this study provide support for the first-order scoring structure of the five WISC-V factors in the 10 subtest primary battery with this large clinical sample.
A comparison of news databases’ coverage of digital-native news
Authors: Gilbert Stacy , Watkins Alexander
Published: September 2020

Digital-native news has become widely read and award-winning sources for news, and it is important to understand if news aggregator databases provide access to these emerging news outlets. This study compares four news aggregators’ coverage of popular and Pulitzer Prize finalists’ digital-native news organizations to print-native news outlets. It found only 14 out of 47 born-digital news organizations are available in the aggregators, and of those outlets, only four have a 100% date coverage.
Family Ministry: Past, Present, Future
Authors: Kjesbo Denise Muir , Cha Lou Y.
Published: September 2020

Within the family ministry movement, various philosophies, curriculum, conferences, and ministry models have been historically developed for the Christian discipleship of families. These resources and models have become an integral part of the local church’s ministry to families within the church, the home, and the community. However, as sociocultural shifts occur in our contemporary context, these changes may necessitate future reconceptualization and a critical contextualization approach to family ministry.
Altered tumor suppressor genes expression in Egyptian pesticide applicators exposed to organophosphate insecticides
Authors: Salem Eman A , Elhalafawy Ibrahim A , Hegazy Mofrih M , Younis Faten E , Swellim Ola A , Sakr Moustafa A
Published: September 2020

Occupational exposure in spraying and application of non-arsenical insecticides has been classified as a probable human carcinogen. The fundamental molecular mechanisms involved the tumor-related genes. This study aimed to investigate the carcinogenesis effects related to chronic exposure to organophosphate (OP) pesticides in pesticide applicators. This was a cross-sectional study conducted on 27 pesticide applicators and 24 matched controls through the period from June to December 2018. The level of acetylcholinesterase (AChE) was determined and the effects of OPs exposure on messenger RNA (mRNA) expression of the DNA-damage responsive genes P53, P21, GADD45a, and MDM2 were determined using real-time quantitative polymerase chain reaction. A significant reduction of serum AChE enzyme activities was observed in chronically exposed subjects in comparison with the control group ( p = 0.001). The expression of P53, P21 mRNA was significantly downregulated in the exposed group compared with the healthy nonexposed control group ( p < 0.05). Conversely, the expression of MDM2 and GADD45a did not significantly differ between the exposed subjects and the control group ( p > 0.05). No significant differences were noted between the exposed and control groups regarding the genotype or allele distributions of P53 Arg72Pro polymorphism. These results suggested that chronic exposure to OP insecticides may have mitogenic and carcinogenicity activity for the exposed cases due to downregulation of P53 and P21 but did not demonstrate any DNA damage properties for the exposed cases, and finally, a regular follow-up of the exposed cases for tumor markers is recommended.
Shared care in surgery: Practical considerations for surgical leaders
Authors: Reid Morgann , Lee Alex , Urbach David R. , Kuziemsky Craig , Hameed Morad , Moloo Husein , Balaa Fady
Published: September 2020

The recent COVID-19 pandemic has highlighted limitations in current healthcare systems and needed strategies to increase surgical access. This article presents a team-based integration model that embraces intra-disciplinary collaboration in shared clinical care, professional development, and administrative processes to address this surge in demand for surgical care. Implementing this model will require communicating the rationale for and benefits of shared care, while shifting patient trust to a team of providers. For the individual surgeon, advantages of clinical integration through shared care include decreased burnout and professional isolation, and more efficient transitions into and out of practice. Advantages to the system include greater surgeon availability, streamlined disease site wait lists, and promotion of system efficiency through a centralized distribution of clinical resources. We present a framework to stimulate national dialogue around shared care that will ultimately help overcome system bottlenecks for surgical patients and provide support for health professionals.
Career Preparedness Among Adolescents: A Review of Key Components and Directions for Future Research
Authors: Marciniak Julian , Johnston Claire S. , Steiner Rebekka S. , Hirschi Andreas
Published: September 2020

Adolescents and students are faced with the developmental task of becoming prepared for a career and master future career transitions. Existing research has investigated a range of concepts relating to career preparedness, including predictors and outcomes. However, this body of work is fragmented as a number of different conceptualizations and measurements related to career preparedness exist. Thus, the goal of this review is to provide an overview of the different concepts that have been used to describe and measure career preparedness. Based on a comprehensive review of empirical articles on maturity, readiness, adaptability, preparedness, and preparation, we propose an organizing framework of the diverse attitudes, knowledge and competencies, and behaviors required for career preparedness. We also review the empirical research on predictors and outcomes of career preparedness. We close by identifying issues in the conceptualization and measurement of different constructs and provide suggestions for future research, and implications for theory and practice.