bluuebunny/crossref_metadata_2025 huggingface dataset:
„Aus unseren Fehlern lernen und besser machen“
Authors:   Monitor Versorgungsforschung, Stegmaier Peter
Published: February 2024

Which of the German corona measures were good, which were bad? What can we learn from the years 2020 to 2022 for future pandemics and other potential crisis situations? These were the key questions posed by MVF editor Prof Dr Reinhold Roski at the start of the MVF Congress ‚Pandemic impact on healthcare‘, the first part of which took place online in December 2023. After the opening statement by Sabine Dittmar MdB, Parliamentary State Secretary at the Federal Ministry of Health, who spoke about the ‚Corona impact on healthcare policy‘, Prof Dr Bertram Häussler, IGES Director and key idea generator of the congress, presented a somewhat different view of the political reality in his lecture ‚Effects of the corona pandemic - an overview‘. A view shared by Prof Dr Matthias Schrappe, University of Cologne, who was not stingy with constructive criticism in his presentation ‚Politics: fear instead of information?‘. The aim of the ‚Monitor Versorgungsforschung‘ congress was precisely not to apportion blame, but to analyse what can not only be learned from the Covid-19 event of the century for the German healthcare system, but what must be learned for future crises of the same or a completely different kind.
Lehren aus hygienisch-medizinischer Sicht
Authors:   German Society for Hospital Hygiene (DGKH), Exner Prof. em. Dr. med. Dr. h.c. Martin , Walger Dr. Peter ,   German Society for Hospital Hygiene (DGKH)
Published: February 2024

The basic premise of preventive health protection through hygiene and infection medicine is to always design corresponding concepts taking into account proportionality and the societal and social consequences (no infection-preventive tunnel vision). It remains inexplicable why, at the beginning of the pandemic, political crisis management decided not to draw on the quality of the preliminary work of the pandemic plan, which was last updated in 2017, and the expertise of preventive health protection experts from the fields of hygiene and infection medicine.
Finding Optimal Location Development UPPKB In South Sumatera Province Using Multi-Criteria Analysis
Authors: Priambudi Bagus Nuari , Ariani Nofa Martina , Hadi Wijaya Muhammad Indra
Published: February 2024

The distribution of commodity transportation is a crucial factor for the sustainability and continuity of economic activities in specific regions. Shipments occur daily, especially on main roads, with the majority of goods transported exceeding tonnage limits when passing through roads. If this continues without control and security measures, it will lead to a deterioration of the physical quality of the road, disrupting the distribution of goods transportation. The Vehicle Weighing Station (UPPKB) is a form of control and security implemented by the government to regulate the transportation of goods distribution above tonnage limits. Every day, the transportation of goods distribution in South Sumatera Province is significant due to its numerous power plants and tourist destinations. This research aimed to identify the location for the development of UPPKB using a quantitative method to obtain indicators for multi-criteria analysis. The conclusion drawn from the identified potential points indicates positive results, making it feasible to construct a new UPPKB at those locations. The potential locations for the development of a new UPPKB in South Sumatera are Betung 1 Street and Yusuf Singadekane 1 Street
LITERASI MEDIA DALAM MENANGKAL INFORMASI HOAKS JELANG KONTESTASI POLITIK 2024
Authors: Nurhaipah Titih , Ramallah Zaqia
Published: February 2024

Indonesia saat ini sedang menjalani tahun politik menjelang perhelatan pemilihan umum (pemilu) pada tahun 2024 mendatang. Media sedang gencar menyajikan ragam informasi politik untuk dikonsumsi oleh publik. Penyebaran informasi hoaks atau berita palsu ini akan sangat menyesatkan membuat suasana tidak kondusif terutama terkait informasi-informasi politik. Penelitian ini bertujuan untuk mengkaji pemahaman terkait pentingnya literasi informasi, khususnya untuk menangkal informasi hoaks dalam suasana pesta politik yang akan segera terselenggara di Indonesia. Selain itu, mengeksplorasi tentang landasan literasi media yang diperuntukkan bagi masyarakat akademis. Metode yang digunakan adalah pendekatan kualitatif yang tidak bertujuan menggeneralisasi suatu fenomena. Hasil dari penelitian yakni literasi menjadi kemampuan dasar bagi publik, terutama publik akademis yang mengonsumsi informasi dalam kehidupannya. Riset ini diharapkan menjadi tambahan pengetahuan bagi publik untuk cerdas dalam konsumsi informasi utamanya informasi politik. Hal ini diperlukan untuk dapat digunakan sebagai rambu agar terhindar dari informasi palsu (hoaks). Dengan demikian terdapat tiga landasan literasi media untuk menambah 1) kemampuan akses informasi politik; 2) filter informasi; dan 3) Rujukan informasi politik yang akurat. Kata Kunci: hoaks, informasi, kontestasi politik, literasi
Stylistic Labels Bookish and Colloquial in Phraseological Dictionaries
Authors: Arbuzova E. M. , Durandin O. V. , Karabasova Yu. A. , Klimova M. A.
Published: February 2024

The article deals with discrepancies between stylistic labels of phraseological units in various dictionaries, which is considered to be one of the deep-rooted issues in lexicography. The authors compiled an electronic dataset of four phraseological dictionaries of the Russian language and then analysed the use of the stylistic labels knizhnoje (bookish) and razgovornoje (colloquial) in them. The results demonstrate considerable discrepancies between the dictionaries both in the set of stylistic labels and in the density of stylistic information. In addition, the relevance of stylistic labels, in particular that of razgovornoje (colloquial), varies considerably. The authors then statistically explored the connection between the stylistic labels knizhnoje (bookish) or razgovornoje (colloquial) and other stylistic characteristics using the chi-square test. Only a few pairs of stylistic labels have been found to possess a statistically significant connection, among them knizhnoje (bookish) and vysokoje (elevated), ustarevshee (archaic) and knizhnoje (bookish) as well as the combination of razgovornoje (colloquial) and emotive and expressive labels. The main differences in the stylistic labeling of one phraseological unit in different dictionaries have been found to include the discrepancy between the labels razgovornoje (colloquial) and prostorechnoje (vernacular) as well as assigning the label knizhnoje (bookish) in one dictionary and the label razgovornoje (colloquial) or prostorechnoje (vernacular) in the other. In the final part of the article, the authors apply a corpus-oriented approach to verify the stylistic labels knizhnoje (bookish) or razgovornoje (colloquial) by comparing the frequency of the corresponding phraseological units in corpora of fiction and colloquial speech respectively. According to the results, less than a half of the analysed phraseological units correspond to the stylistic label assigned to them in the dictionary. The debatable cases in terms of being knizhnoje (bookish) or razgovornoje (colloquial) were then analysed and found to predominantly occur in the corpus of fiction. On the basis of the findings it is concluded that the corpus-oriented approach can be used for assigning and verifying stylistic labels as long as the technical limitations and the heterogeneity of the units in phraseological dictionaries are taken into account.
The effect of the presence of brackets on the reliability of measurements made on three-dimensional digital models
Authors: Kutlu Esra Tuhan , Karsli Nurver
Published: February 2024

Objectives:

Digital model scans are frequently used today at the beginning and intermediate stages of orthodontic treatment. The aim of this study is to evaluate the effect of orthodontic brackets on linear measurements made on three-dimensional digital models.

Material and Methods:

Dental models were obtained from 40 patients before orthodontic treatment and in the first treatment session. Dental plaster models were converted into digital models using the 3Shape R700 (3Shape, Copenhagen, Denmark) model scanner. Intraoral scans were created with the Shape Trios3 (3Shape, Copenhagen, Denmark) intraoral scanner. Digital models were transferred to the Orthoanalyzer program (3Shape, Copenhagen, Denmark), and linear measurements were made.

Results:

There was no significant difference in the measurements made in intraoral scans scanned with and without brackets. No significant difference was observed in the measurements made on model scans with and without brackets (P > 0.05).

Conclusion:

Digital scanner systems, which are increasingly used with developing technology, provide safe and effective results even in the presence of brackets.
Self-induced skin lesions in dermatology
Authors: Shah Shikha , Narang Tarun
Published: February 2024

Self-induced skin lesions comprise lesions on skin, mucosa, and/or appendages, which are produced by the patients themselves and not being a consequence of any underlying physical or mental health disorder. These include impulse control disorders such as hesitation cuts, various compulsive behaviors such as trichotillomania, as well as body dysmorphias. These disorders are not infrequent in dermatological practice and perplex the clinician not only with their bizarre presentations but also challenging in terms of management of the “psyche” along with the “skin.” The present article aims to bring to perspective a dermatological peek and view into the self-harm domain in psychodermatology.
Efficacy and safety of crisaborole ointment in pediatric atopic dermatitis: A 4-week open-label study
Authors: De Abhishek , Chakraborty Disha , Grisilda B. Namratha , Chaudhuri Sirshendu , Godse Kiran , Dhar Sandipan
Published: February 2024

Objectives:

Managing mild-to-moderate atopic dermatitis (AD) often necessitates topical therapies, and one such recently introduced option is crisaborole ointment. This study sets out to assess the efficacy and safety of crisaborole ointment in pediatric cases of AD over four weeks.

Material and Methods:

Nineteen children between 2 and 16 years old with mild-to-moderate AD were enrolled and treated with crisaborole ointment twice daily in affected areas for 30 days. The primary objective was to appraise the shift in the investigator’s static global assessment (ISGA) scores (0–4) every week for the four-week follow-up. The severity of pruritus score (SPS) was another secondary objective. Furthermore, individual indicators of clinical signs that included erythema, exudation, excoriation, induration/papulation, and lichenification, were examined with subjective scores (0–3). Children’s dermatology quality of life index (CDLQI) was employed to study the quality of life.

Results:

Following four weeks of crisaborole ointment treatment, the average ISGA score declined from 2.58 ± 0.61 to 0.95 ± 0.78, signifying a substantial reduction in AD severity (P< 0.001). The SPS score also decreased from a mean of 2.32 ± 0.478 to 0.84 ± 0.60 (P< 0.001), underscoring a significant reduction in itching. Moreover, individual markers for clinical signs of AD, including erythema, exudation, excoriation, induration/papulation, and lichenification, all exhibited statistically significant improvement. Crisaborole ointment was well tolerated. Only 6 of the 19 patients reported a localized burning sensation, which was manageable. No patient needed to be withdrawn during the study period. The CDLQI showed a substantial drop in scores, decreasing from an average of 13.79 ± 3.57 at the commencement to 6.74 ± 1.97 (P< 0.001). Furthermore, 14 out of 19 patients met the study’s primary goal, achieving at least a 2-point reduction in ISGA along with the attainment of clear or nearly clear skin (ISGA 0–1).

Conclusion:

Our study found crisaborole ointment significantly improved pediatric AD symptoms and was well-tolerated. The only adverse event was localized burning in a few patients. Further, research is needed for validation.
Drug reprofiling: from random observation to systematic development
Authors: Малышев И.Ю. , Кузнецова Л.В. , Буданова О.П. , Гусева М.Н. , Лобанов Е.В.
Published: February 2024

Появление таких новых заболеваний, как COVID-19, и устойчивость опасных заболеваний к существующим лекарствам, породили спрос на быструю разработку новых лекарственных средств. Для повышения эффективности, сокращения сроков и финансовых затрат на разработку медицинских препаратов была предложена концепция перепрофилирования лекарств. Перепрофилирование – это стратегия выявления новых медицинских показаний для уже одобренных лекарств. В обзоре представлены современные вычислительные и экспериментальные подходы к поиску лекарств – кандидатов на перепрофилирование, а также проблемы, лежащие на этом пути.

The emergence of new diseases such as COVID-19 and the resistance of dangerous diseases to existing drugs have created a demand for the rapid development of new drugs. The concept of drug repurposing has been proposed to improve the efficiency, reduce time and financial costs of drug development. Repurposing is a strategy for identifying new medical indications for already approved medicines. The review presents modern computational and experimental approaches to the search for drug candidates for repurposing, as well as the problems that lie along the way.
Unknown Motets of 1682 by Johann Kuhnau: A Discovery in St. Petersburg
Authors: Шабалина Т.В.
Published: February 2024

В Иностранном книжном фонде Российской национальной библиотеки автором статьи обнаружено оригинальное печатное издание двух неизвестных ранее мотетов выдающегося немецкого композитора, кантора школы Св. Фомы и музикдиректора в Лейпциге Иоганна Кунау (1660–1722). Сочинения написаны для четырех голосов и опубликованы в виде исполнительских партий. На основе изучения текста, предшествующего мотетам в найденном конволюте, и обстоятельств биографии композитора выяснено, что исполнение произведений состоялось в дрезденской Фрауэнкирхе 29 декабря 1682 года на траурной службе по знаменитому в те годы математику, химику, медику и астроному Михаэлю Крюгенеру (1610–1682). К этому времени Кунау находился уже в Лейпциге, и обнаруженные сочинения можно считать первыми известными на сегодня его лейпцигскими опусами. Дается анализ формы мотетов и их музыкального языка, делается вывод о значимости найденных произведений для изучения раннего периода творчества композитора и пополнения наших знаний о его вокальной музыке. Статья основана на материале одной из глав книги автора «“Texte zur Music” in Sankt Petersburg: Gedruckte deutsche Quellen zu Werken von Komponisten des 17. und 18. Jahrhunderts» (Beeskow: Ortus, 2021) и впервые на русском языке представляет находку мотетов Кунау.

An original print of two unknown motets by the outstanding German composer, the cantor of the Thomas school and music director in Leipzig Johann Kuhnau (1660–1722) was discovered by the author of this article in the Foreign Books Department of the National Library of Russia. The works were written for four voices and published as the performance parts. Based on research of the previous unite in the found convolute and events of the composer’s biography it is revealed that the motets were performed in the Frauenkirche in Dresden on 29 December 1682 at the funeral service for a famous mathematician and chemist, as well as medico and astronomer Michael Krügener (1610–1682). By that time Kuhnau had lived in Leipzig and the discovered pieces can be considered his first known works composed in that city. The analysis of the motets and their musical language is given in the article. The conclusion about their significance for the study of the early period of the composer’s work and widening of our knowledge of his vocal music is drawn. The article is based on the chapter of the book “‘Texte zur Music’ in Sankt Petersburg: Gedruckte deutsche Quellen zu Werken von Komponisten des 17. und 18. Jahrhunderts” (Beeskow: Ortus, 2021) and presents for the first time the finding of the motets in the Russian musicology.
The Symphonic Work by Per Nørgård: The Trajectory of the Genre’s Development
Authors: Окунева Е.Г.
Published: February 2024

В статье рассматривается эволюция симфонического творчества одного из ведущих датских композиторов современности Пера Нёргора. Восемь симфоний, созданных им в период с 1953 по 2011 год, обладают комплексом своеобразных черт и демонстрируют индивидуальный подход к жанру. В статье дается их общая характеристика, выявляется роль Сибелиуса и Хольмбу в творческом становлении Нёргора, раскрываются принципы композиционного устройства циклов, прослеживаются связи с традицией. Особое внимание уделяется оригинальной композиторской технике (принципу «бесконечной серии», системе мелодической, гармонической и ритмической иерархии, методу «тоновых озер») и ее связям с художественной концепцией сочинений. Предлагается периодизация симфонического творчества, эволюция которого, по мнению автора статьи, подчинена диалектической логике. Начиная как продолжатель скандинавской (и, шире, европейской) симфонической традиции, в основе которой лежит гуманистическая идея, композитор в дальнейшем концентрируется на вопросах иерархического устройства мира и самодвижения звуковой материи. В сочинениях позднего периода он вновь возвращается к теме Человека и Мира, которая приобретает новое «звучание» благодаря накопленному опыту.

The article discusses the evolution of the symphonic work of one of the leading Danish composers of our time, Per Nørgård. Eight symphonies created by him in the period from 1953 to 2011 have a complex of peculiar features and demonstrate an individual approach to the genre. The article gives their general characteristics, reveals the role of Sibelius and Holmboe in the creative development of Nørgård, uncovers the principles of the compositional structure of cycles, and traces the links with tradition. Special attention is paid to the original compositional technique (the principle of “infinite series”, the system of melodic, harmonic and rhythmic hierarchy, the method of “tone lakes”) and its connections with the artistic conception of compositions. The author proposes a periodization of symphonic work and suggests that its evolution is subject to dialectical logic. Starting as a follower of the Scandinavian (and, more broadly, European) symphonic tradition, which is based on a humanistic idea, the composer later focuses on an issues of the hierarchical structure of the world and the self-movement of sound matter. In the works of the later period, he returns to the theme of the Man and the World, which acquires a new “sound” thanks to the accumulated experience.
Deciphering the Well-Known: Songs in Leonid Gaidai’s Films “The Diamond Arm” and “Ivan Vasilyevich Changes His Profession”
Authors: Журкова Д.А.
Published: February 2024

Материалом данной статьи стал песенный саундтрек в двух безусловных шедеврах Леонида Гайдая — фильмах «Бриллиантовая рука» (1968) и «Иван Васильевич меняет профессию» (1973). Несмотря на то что песни из этих фильмов воспринимаются как безобидные разбитные хиты советской киномузыки, они содержат в себе множество двойственных смыслов, которые не подвергались пристальному анализу. В статье разбирается семантика музыкальных цитат и оригинальных внутрикадровых музыкальных номеров. В саундтреке «Бриллиантовой руки» выявляются «вторые» смыслы песен «Остров невезения», «Песня про зайцев» и «Вулкан страстей». С одной стороны, эти песни несли в себе завуалированную критику советских реалий, а с другой — существенно обогащали драматургию фильма, сообщая стандартным комедийным ситуациям и героям незаурядную глубину.  Схожие драматургические и смысловые алгоритмы прослеживаются в саундтреке кинокомедии «Иван Васильевич меняет профессию», в частности в песнях «Звенит январская вьюга», «Маруся» и «Разговор со счастьем». Напластование исторических времен, заявленное в сюжете фильма, позволило авторам заострить проблематику оригинальных песен и одновременно сделать объектом высмеивания клише советской музыкальной эстрады.

The material for this article is the song soundtrack in two absolute masterpieces of Leonid Gaidai — “The Diamond Arm” (1968) and “Ivan Vasilyevich Changes His Profession” (1973). Despite the fact that the songs from these films are perceived as harmless hits of  Soviet film music, they carry a lot of dual meanings that have not yet been subjected to close analysis. The author of the article examines the semantics of musical quotes and original intraframe musical pieces. In the soundtrack of “The Diamond Arm” the “second” meanings of the songs “Island of Bad Luck,” “Song about Hares” and “Volcano of Passions” are revealed.  On the one hand, these songs carried a veiled criticism of Soviet realities, and on the other hand, they significantly enriched the dramaturgy of the film by giving extraordinary depth to standard comedy situations and characters. Similar dramatic and semantic algorithms can be traced in the song soundtrack of the comedy film “Ivan Vasilyevich Changes His Profession,” in particular in the songs: “The January Blizzard is Clinking,” “Marusya” and “Conversation with Happiness.” The stratification of historical times, stated in the plot of the film, allowed the authors to sharpen the topics of the original songs and at the same time — to make the clichés of the Soviet musical stage an object of ridicule.
STUDY OF COMMUNAL BASIUNI IMRAN ISLAMIC BOARDING SCHOOL WASTEWATER TREATMENT PLANT (WWTP) IN SAMBAS REGENCY
Authors: Andini Medina , Apriani Isna , Pramadita Suci
Published: February 2024

Islamic Boarding School has a treatment capacity of 33 m3 and an area of 24 m2. Based on the results of initial wastewater quality tests on communal WWTP, the TSS, COD, and BOD parameters are above the quality standard threshold based on the Wastewater Quality Standard of the Minister of Environment Regulation Number 68 of 2016. This evaluation aims to determine the processing efficiency of communal WWTP and evaluate the processing unit in communal WWTP as well as alternative improvements that effectively reduce the parameters of pH, TSS, BOD, COD, and fatty oils. This research method is descriptive analytics, which analyses problems from data collected descriptively to find solutions to problems. The results of this evaluation show that the TSS, COD, and BOD parameters are above the quality standard threshold. The pH parameter increased by 3.6%, removal efficiency for BOD by 76.4%, COD by 71.9%, TSS by 84.3%, and oil grease by 91.9%. Alternative WWTP improvements are carried out by redesigning the Communal WWTP, which consists of calculating the equalization unit, precipitator I, anaerobic filter, Precipitator II, disinfection, and sludge thickener, Sludge digester, sludge drying bed and analysis of the Budget Plan Cost (RAB). The communal WWTP redesign requires a land area of 52.62 m2 with a processing capacity of 56.8 m3 and a cost budget plan of Rp.157,224,000.00. The redesign results of this evaluation can reduce environmental impacts due to domestic wastewater.
Native mass spectrometry reveals binding interactions of SARS-CoV-2 PLpro with inhibitors and ISG15
Authors: James Virginia , Godula Rianna , Perez Jessica , Butalewicz Jamie , Sipe Sarah , Huibregtse Jon , Brodbelt Jennifer
Published: February 2024

Here we used native mass spectrometry (native MS) to probe a SARS-CoV protease, PLpro, which plays critical roles in coronavirus disease by affecting viral protein production and antagonizing host antiviral responses. Ultraviolet photodissociation (UVPD) and variable temperature electrospray ionization (vT ESI) were used to localize binding sites of PLpro inhibitors and revealed the stabilizing effects of inhibitors on protein tertiary structure. We compared PLpro from SARS-CoV-1 and SARS-CoV-2 in terms of inhibitor and ISG15 interactions to discern possible differences in protease function. A PLpro mutant lacking a single cysteine was used to localize inhibitor binding, and thermodynamic measurements revealed that inhibitor PR-619 stabilized the folded PLpro structure. These results will inform further development of PLpro as a therapeutic target against SARS-CoV-2 and other emerging coronaviruses.
Triethoxysilane-Catalyzed Sequential Regioselective Hydroboration of Terminal Alkynes: Sustainable Access to E-Alkenylboronate and Alkyl Gem-Diboronate Esters
Authors: Kaur Harleen , Ahuja Himani , Arevalo Rebeca
Published: February 2024

The commercial reagent, HSi(OEt)3, was an efficient catalyst for the synthesis of E-alkenylboronate esters and alkyl gem-diboronate esters by single or double hydroboration of terminal alkynes with HBPin (pinacolborane). The reaction time controlled whether a single or a double addition of HBPin to the alkynes occurred. Aromatic terminal alkynes containing strong electron-donating or -withdrawing substituents at different positions as well as aliphatic alkynes were efficiently mono- and dihydroborated. Mechanistic studies suggested that the formation of diboronate esters proceeds by a double hydroboration with the second hydroboration cycle being the rate determining. The reaction of HSi(OEt)3 with HBPin has been identified as a catalyst deactivation pathway operative in catalysis. Screening of other silicon compounds for this transformation supported that the steric and electronic profile of HSi(OEt)3 is key to promote the second hydroboration step.
Sulfenylnitrene-Mediated Nitrogen-Atom Insertion into Pyrroles, Indoles, and Imidazoles
Authors: Ghosh Bidhan , Kafle Prakash , Mukherjee Rishav , Welles Randall , Herndon Deacon , Nicholas Kenneth , Shao Yihan , Sharma Indrajeet
Published: February 2024

In this study, we harness the distinct reactivity of sulfenylnitrenes, which insert a single nitrogen atom to transform readily available pyrroles, indoles, and imidazoles into synthetically challenging pyrimidines, quinazolines, and triazines, respectively. Our additive-free method for skeletal editing employs easily accessible, benchtop-stable sulfenylnitrene precursors as a source of a single nitrogen atom. This chemical approach is compatible with free pyrroles, indoles, and imidazoles with diverse functional groups, including oxidation-sensitive functionalities like phenol and thioether. Additionally, this approach facilitates the selective incorporation of a single nitrogen atom into various natural products, amino acids, and pharmaceuticals. Furthermore, we have conducted mechanistic studies and explored regioselectivity outcomes through DFT calculations.
Click3D: A whole-organ 3D imaging method utilizing tissue clearing-compatible click reaction
Authors: Tamura Iori , Sakamoto Daichi M. , Yi Bo , Saito Yutaro , Yamada Naoki , Morimoto Jumpei , Takakusagi Yoichi , Kuroda Masafumi , Kubota Shimpei I. , Harada Hiroshi , Tainaka Kazuki , Sando Shinsuke
Published: February 2024

Click chemistry stands as an invaluable chemical technology, offering a multitude of applications through highly selective and efficient bioorthogonal reactions under biological environments. In the realm of bioimaging, pre-targeting strategies have often been employed, utilizing click reactions between molecular probes with a click handle and reporter molecules that make them observable. Recent efforts have integrated state-of-the-art tissue-clearing techniques with fluorescent labeling through click chemistry, allowing high-resolution 3D fluorescence imaging of the target molecules. Nevertheless, these techniques have faced a challenge in terms of limited staining depth, confining their use to imaging tissue sections or partial organs. In this study, we introduce Click3D, a method for thorough staining of whole tissues and whole organs using click chemistry. We identified click reaction conditions that improve staining depth with our custom-developed click staining depth assay. The Click3D protocol, optimized by incorporating these conditions, exhibits a substantially greater staining depth compared to conventional methods. Through the implementation of Click3D, we have successfully achieved whole-kidney imaging of nascent RNA and whole-tumor imaging of hypoxia. Remarkably, we have also accomplished whole-brain imaging of hypoxia by employing the clickable hypoxia probe, which has a small size and, therefore, has high permeability to cross the blood-brain barrier. The Click3D method, leveraging the versatility of click chemistry, is a foundational technology and is expected to have diverse applications employing various clickable probes.
Enhancing the Performance of Natural Fiber Hybrid Green Composites through Coupling Agent modification
Authors: ISLAM MD.
Published: February 2024

The search for sustainable resources has led to the use of biodegradable natural fibres in composites. As of now, no study has been performed on the fabrication of hybrid natural fiber green composite through coupling agent modification. Thus, this study investigates the fabrication of green composites using a hybrid blend of Empty Fruit Bunch (EFB) and Kenaf fibers utilizing coupling agent modification and hot compression method. The FTIR results indicates that the MAH was successfully reacted with the cellulose backbone of the fibers. The SEM result reveal that the surface morphology of green composite has been smooth after MAH modification. The coupling agent also improves fiber-PLA matrix bonding, improving the green composite's tensile strength, modulus, impact strength, and thermal stability. In addition, composites water absorption was shown to be decreased as a result of the treatment of MAH.
Aprendizaje basado en problemas para el desarrollo de competencias en estudiantes. Revisión sistemática de literatura
Authors: Amador  Alarcón Maria del Pilar , Torres Gastelú Carlos Arturo , Lagunes Domínguez Agustín
Published: February 2024

Los desafíos en la educación han permitido explorar nuevas estrategias innovadoras que permiten a los estudiantes resolver problemas acercándolos a una realidad que se enfrentarán en el mundo profesional. Este estudio tiene como objetivo realizar una revisión sistemática sobre el Aprendizaje Basado en Problemas (ABP) para el desarrollo de competencias. La metodología se desarrolló en dos fases, heurística y hermenéutica. Para la primera fase, los criterios de búsqueda que se implementaron fueron el análisis de artículos de investigación y tesis doctorales, que comprendieran los años 2016 al 2022. Para ello, se seleccionaron bases de datos especializadas en la producción científica. Para la fase hermenéutica se establecieron dos niveles educativos: 1) medio superior y 2) superior, y los siguientes ejes analíticos: a) desarrollo de competencias, b) tipo de estudio y c) área de impacto. Los resultados de los estudios revisados muestran el impacto positivo que generó e influyó el ABP en su desarrollo académico en los estudiantes. Se concluye que la implementación del ABP promueve el aprendizaje, el desarrollo de competencias transversales, genéricas, digitales, básicas, colaborativas, comunicativas y el trabajo colaborativo de los alumnos; siendo esta una alternativa para implementar este método de aprendizaje para el desarrollo de competencias digitales en estudiantes.
La animación como herramienta para la comprensión lectora en niños durante la pandemia del COVID-19
Authors: Olvera Mejía Yair Félix , Gea Pérez Mario Alberto , Reséndiz Ramírez Ivone Vidalia , Ortiz Duran Mitzi Abigait
Published: February 2024

En el presente texto se presenta el diseño, desarrollo y aplicación de una app móvil basada principalmente en video cuentos animados, que tiene como finalidad complementar los procesos educativos para que los niños de educación básica comiencen a aprender a leer y a comprender lo que leen mediante actividades que pueden realizar en la escuela o en casa. Se presentan diversos video cuentos animados adaptados de historias y leyendas mexicanas. Durante el confinamiento generado por la pandemia del Covid-19, se proporcionó la app móvil a padres y madres de familia con hijos en preescolar o en los primeros grados de primaria para que la implementen en casa durante sus clases en línea. Los comentarios fueron positivos, ya que los dibujos animados y videojuegos llaman mucho la atención de los niños, por lo que se genera un aprendizaje autónomo, además de que son actividades que disfrutan mucho a esa edad. Con ello se fomenta el uso de la animación 2D y 3D dentro de estrategias innovadoras que permitan al infante desarrollar nuevas habilidades.
Prevalence, risk factors and outcomes associated with Gestational Diabetes Mellitus according to the IADPSG and NICE criteria in Mexico
Authors: Violante Ortíz Rafael , Reyna-Beltrán Elizabeth , Requena-Rivera Claudio Abel , Tavera Tapia Alejandra
Published: February 2024

In Mexico, there is still no consensus of a criteria for the diagnosis of Gestational Diabetes Mellitus (GDM). The objective was to compare characteristics among GDM diagnostic criteria by the International Association of Diabetes and Pregnancy Study Groups (IADPSG) and the National Institute for Health and Clinical Excellence (NICE) in Mexico. A prospective and descriptive study was conducted in the Northeast region of Mexico. Prevalence, risk factors, maternal-fetal outcomes were evaluated. GDM prevalence was ​​44.5% by IADPSG and 37.5% by NICE. The analysis of risk factors and outcomes tended to be equal between criteria; nonetheless, the use of only IADPSG or NICE criteria limited the number of patients diagnosed with GDM, leading to a percentage of misclassified cases. IADPSG criteria seem to have fewer limitations to identify GDM patients than NICE due to the characteristics of the cohort. Although, determining in parallel NICE criteria, could be complementary for GDM diagnosis in Mexico. As conclusions, we propose the assessment of both criteria (IADPSG and NICE) to identify the largest number of women at risk of GDM. The lack of significant differences in outcomes between criteria reflects the importance of opportune treatment for GDM patients, which is not administered in a percentage of GDM missed cases when only one criterion is used.
Experiencias corpóreas, emocionales y de habitabilidad en jóvenes universitarios: efectos del confinamiento social por la Covid19
Authors: Salazar Jasso Aileen Azucena , Sánchez Carballo Alfredo , Bonilla Rocha Venus María Piedad
Published: February 2024

El objetivo del trabajo es conocer las formas de habitar las viviendas durante el confinamiento por el Covid19 debido a la reconfiguración de actividades escolares y laborales, así como reconocer las manifestaciones emocionales derivadas de dichos cambios. El diseño metodológico fue cualitativo mediante grupos focales conformados por estudiantes universitarios de la licenciatura en Psicología. Los estudiantes realizaron cambios en el habitar de sus viviendas en torno a la reorganización del uso de los espacios para las actividades escolares y laborales, la convivencia familiar, el uso del tiempo en casa, y en los hábitos de alimentación y del sueño. Una de las limitaciones del estudio fue la necesidad de realizar el trabajo de campo a través de plataformas virtuales debido a la contingencia sanitaria. No obstante, el haber realizado los grupos focales durante el confinamiento permitió aproximarnos a la experiencia de lo que estaban viviendo los jóvenes en sus hogares. Con el estudio se identificaron las tensiones psicosociales que surgieron en el confinamiento por el covid19 en los hogares de los estudiantes universitarios y la modificación de hábitos cotidianos en la organización socioespacial de la vivienda.
Cloud Based Data Centre for Managing Logistics in the Disaster
Authors:   Department of Information Technology Greater Noida Institute of Technology (Engineering Institute), India, Yadav Abhishek , Dubey Dr.Shivani ,   Department of Information Technology Greater Noida Institute of Technology (Engineering Institute), India, Singhal Prof.Vikas ,   Department - Information Technology Greater Noida Institute of Technology (Engineering Institute), India, Sahu Dr.Ajay kumar ,   Department - Information Technology Greater Noida Institute of Technology (Engineering Institute), India
Published: February 2024

Considering the many man-made and natural disasters that have occurred in recent years, such as the September 2001 earthquake and the tsunami in Japan, the importance of problem solving processes cannot be ignored. The total damage caused by the disaster in Japan alone is estimated at more than $300 billion. Transportation and communications play an important role in disaster response and management to minimize loss of life, economic costs and impacts. Our research includes the development of emergency response systems for disasters of all sizes, focused on transportation systems designed to use and communicate information and technology. In this article, we discuss the use of technology for disaster management using smart transportation, including mobile, mobile and cloud. The system is intelligent because it can collect information from many places and locations, including the situation and make decisions regarding the use of the communication process, making the vehicle more efficient. Hybrid vehicle communications based on vehicle-to-vehicle and vehicle-to-infrastructure protocols are being exploited opportunistically. The effectiveness of our system has been demonstrated by simulating the impact of disasters on the real urban environment and comparing the situation with our existing disaster management systems. We declare that the adoption of our plan has led to the improvement and stabilization of traffic and evacuation.
Exploration of The Birth Planning and Complications Prevention Program Implementation
Authors: Pattipeilohy Claudia Igreya , Maelissa Merlin Margreth , Mainase Josephina , Titaley Christiana Rialine , Malakauseya Maxwell Landri Vers , Nari Janti Pare
Published: February 2024

The Birth Planning and Complications Prevention Program or Program Perencanaan Persalinan dan Pencegahan Komplikasi (P4K) is an effort by the government to reduce the maternal mortality rate in Indonesia. This study aimed to determine the implementation of P4K to reduce maternal mortality in the catchment area of Waihaong Health Center Ambon in 2020. This was a qualitative study with a case study approach. Data collection was conducted in February-May 2020 in the catchment area of Waihaong Health Center. There were 13 informants interviewed in this study (nine pregnant women, two health workers, and two cadres). Data analysis was conducted using content analysis by identifying the emerging themes based on the research objectives. The results of this study show that the implementation of P4K has been running, but it has yet to be maximized because several P4K components still need to be completed. The pregnant woman prepares the components in the P4K sticker without any discussion with the midwife, and some pregnant women still choose to give birth with the help of a traditional birth attendant or “mama biang”. The mother's need for more knowledge about P4K and the lack of human resources as a program administrator was an obstacle to implementing this program. This study indicates that there is still a need for counseling for pregnant women to increase knowledge and awareness of the benefits of P4K and to carry out further training and collaboration between midwives and village cadres to improve P4K implementation.
Impact of Stunting History on Adults: Literature Review
Authors: Permaida Permaida
Published: February 2024

Stunting is the root of the problem that affects human growth and development. This problem starts from the growth of the fetus until the first 1000 days of life. If not addressed, it will have long-term impacts. This article aimed to determine the impact of a history of stunting on adults. This research method uses a literature review. Article searches using the Taylor and Francis, Science Direct, and Springer Link databases. Seven articles met the inclusion criteria. The research results showed that 28.5% of the articles were researched in developed countries and 71.5% in developing countries. However, there are no research articles from Indonesia. Researchers found the impact of a history of stunting on adults, including 87.5% of articles describing physiological consequences, 66.7% of all articles mentioning cognitive obstacles, and 57.1% of all articles evidencing psychosocial problems. In conclusion, the impact of a history of stunting on adults is confirmed and a polemic that must be addressed immediately. If left untreated, this will continue to happen, becoming a scary cycle and reducing the quality of human resources.
Calculation in the Agro-Industrial Complex: The Institutional Aspect
Authors: Potokina E. S.
Published: February 2024

The purpose of the article is to study the application of an institutional approach to product calculation to study the asymmetry of information on production costs at enterprises of the agro-industrial complex (AIC). This problem is formulated in the context of the categories “uncertainty, rational choice, opportunism”; sources of asymmetry for the crop industry are identified in the form of uncertainty of cost elements, irrationality of using methods of production accounting and choosing distribution bases, causes of opportunism of accounting staff. Within the framework of the study, the improvement of cost calculation is based on the application of the provisions of the theory of institutional economics, a systematic analysis of economic processes in the field of agriculture and AIC, the theory of accounting for production costs and calculation. The author has established that at different historical stages of the development of accounting, the calculation methodology was improved under the influence of the prevailing economic system, determined by the regulator and routines. Such criteria as the type of uncertainty, the nature of the impact on costs, the institutions formed, and the management of uncertainty reduction are substantiated and proposed as criteria determining the institutional approach to the study of calculation. In the course of the work, dialectical and logical general scientific methods were used — analysis, synthesis, abstraction, generalization, induction, deduction, analogy. We believe that the results of the study and the author’s recommendations will be useful to specialists of the Ministry of Finance of the Russian Federation and the Ministry of Agriculture of the Russian Federation, and will also find application in educational institutions in the training of economists for agriculture.
Penentuan Jumlah Pengadaan Stok Bahan Baku dengan Metode Fuzzy Sugeno pada UMKM XYZ
Authors: Indroyono Abyan Akbar , Churniawan Agus Dwi , Nurcahyawati Vivine
Published: February 2024

Dalam konteks manajemen stok bahan baku, fluktuasi yang signifikan antara tingkat pengelolaan yang tinggi dan rendah seringkali menghambat kelancaran proses pembelian, mengakibatkan kendala seperti permintaan yang tinggi dan ketersediaan bahan baku yang tidak memadai. Terutama pada Usaha Mikro, Kecil, dan Menengah (UMKM) XYZ yang beroperasi dalam industri produksi kopi, dinamika ini dipicu oleh praktik pembelian berdasarkan estimasi yang dilakukan untuk memenuhi stok bulanan yang telah ditetapkan. Penelitian ini merumuskan solusi dengan merancang aplikasi yang mengadopsi metode Fuzzy Sugeno untuk memprediksi pembelian bahan baku.Aplikasi yang dihasilkan mampu memberikan proyeksi akurat terhadap kebutuhan pembelian bahan baku setiap bulan, dengan dasar histori produksi dari satu tahun sebelumnya. Selain itu, aplikasi ini memberikan UMKM XYZ kemampuan untuk melakukan analisis dengan metode perhitungan otomatis, membawa dampak positif pada efisiensi operasional. Evaluasi kinerja aplikasi, dilakukan dengan menggunakan Metode Mean Absolute Percentage Error (MAPE), menghasilkan nilai 33,4%, yang menunjukkan tingkat akurasi yang tinggi dalam perhitungan fuzzy. Secara keseluruhan, penelitian ini tidak hanya memberikan solusi praktis untuk permasalahan pengelolaan stok bahan baku, tetapi juga membuktikan efektivitas metode Fuzzy Sugeno dalam meningkatkan ketepatan prediksi dalam konteks pengambilan keputusan bisnis.
Komunikasi Interpersonal Pelatih dengan Motivasi Berprestasi Atlet Nomor Lari
Authors: Refiater Ucok Hasian , Haryanto Arief Ibnu
Published: February 2024

Interpersonal communication of a coach is carried out to familiarize themselves with athletes, the hope is that the coach can know what the athlete is thinking as well as the coach can include positive motivations for athletes including achievement motivation. This study aims to determine the relationship between the interpersonal communication of coaches with the achievement motivation of track number athletes in Gorontalo City. This research is a correlational study with the entire study population as a sample of 18 athletes. The research instrument used closed questionnaires on interpersonal communication variables with verbal and nonverbal factors, while achievement motivation variables with risk factors for task selection, feedback, responsibility, creative-innovative, task completion time, and having realistic goals. As a result, this study revealed that there was no significant relationship between the interpersonal communication of trainers and the achievement motivation of track and field athletes in Gorontalo City. Further research needs to be conducted to investigate so that the achievement motivation of track number athletes in Gorontalo City becomes even higher. The researcher recommends that coaches can take other approaches in an effort to increase the motivation of their athletes.
Pengembangan Latihan Small-Sided Games Untuk Meningkatkan Kemampuan Kondisi Fisik Dan Keterampilan Teknik Passing Control
Authors: Fitriyah Nabilah , Widodo Achmad , Sulistyarto Soni , Hartono Soetanto , Subagio Irmantara , Wismanadi Himawan , Rizki Ainun Zulfikar
Published: February 2024

This research aims to develop Small-Sided Games Training to Improve Physical Conditioning and Control Passing Technique Skills. This research is development research. Based on data analysis of expert validation results related to small-sided games products, the result was that validator 1 got a percentage of 93.75%. So that it gets a category suitable for use with a very valid category with information that it can be used without revision. The results of validator 2 got a percentage of 96.87%. So that it gets a category suitable for use with a very valid category with information that it can be used without revision. The results of validator 3 got a percentage of 90.62%. So that it gets a category suitable for use with a very valid category with information that it can be used without revision. Small sided games products model 3 vs 3 + 1 neutral and 5 vs 5 +1 neutral, suitable for use as a training model. This can be seen from the results of the validator score data analysis with the category suitable for use and also the pulse result zone which is included in the training zone. Football coaches can use this small sided games model to find out how to improve the playing abilities of young players at the football school (SSB) they train or the football club they coach. This training model product can be used as a reference for football coaches to develop other products within the scope of football training evaluation.