bluuebunny/crossref_metadata_2025 huggingface dataset:
Nutrient support for preschool children with psychomotor disorders
Authors: Pushnyk A.I. , Nуankovskyy S.L.
Published: March 2023

Background. Children with psychomotor disorders are vulnerable to nutrient deficiencies, which significantly complicate their rehabilitation. The purpose of our study was to identify the nutrient deficiencies in preschool children with psychomotor disorders by analyzing their diet, revealing the relationship between the detected nutrient deficiencies, the gender of the children and their psychomotor disorders in order to improve the effectiveness of rehabilitation. Materials and methods. The diet of 53 preschool children with psychomotor disorders was analyzed using the Child’s Eating Behavior questionnaire, followed by analysis with the licensed computer program Dietplan7. Statistical processing was conducted using parametric and correlational analysis. Results. Different violations of eating behavior in children with psychomotor disorders were determined. They included, in particular, the refusal to consume a number of healthy foods, while preferring mainly semi-finished products, fast food, smoked products, rich in salt and sugar, spices. The diet of most examined children was unbalanced in terms of the content of basic nutrients, vitamins and minerals: an excess of proteins, fats and calories, numerous combined vitamin and mineral deficiencies were detected. A reliable correlation was found between the daily consumption of nutrients and neurological pathology that was most significant in subgroups of children with mental retardation. Conclusions. In the food diet of many children with psychomotor disorders, there were unhealthy eating patterns typical of the Western diet. Numerous deficiencies in the daily consumption of basic nutrients, including vitamins and minerals, were found in them, which had a probable correlation with neurological disorders. To improve the effectiveness of the rehabilitation of children with psychomotor disorders, a multidisciplinary approach is advisable with the involvement of a nutritionist for personalized correction of the child’s diet.
Anti-inflammatory effect of breast milk miR-148a on the state of mucous membranes in premature newborns
Authors: Abaturov O.E. , Tovarnytska A.O.
Published: March 2023

Background. Breast milk (BM) is an optimal nutritional product for newborns and a source of exogenous microRNAs (miR). MiR-148a is one of the most highly expressed miR of BM. Currently, there is a lack of data on the miR-148a effect on the development of necrotizing enterocolitis (NEC) in premature newborns. The purpose of the study was to determine the influence of miR-148a of the mother’s BM on the risk of NEC development in preterm newborns. Materials and methods. We examined 74 newborns, who were treated in neonatal departments. We determined the level of miR-148a in the BM of 44 mothers of exclusively breastfed children. In parallel, we evaluated gene expression of the transcription factor T-bet in scrapings of the buccal mucosa of all the newborns. Three groups for comparison were selected: group 1 consisted of 32 newborns up to 37 weeks of gestation on breastfeeding (BF); group 2 — of 30 preterm newborns on artificial feeding; the control group — 12 full-term newborns on BF. Results. The gestational age median of group 1 children was 33 (31; 34) weeks; group 2 — 32.5 (32; 35) weeks; and it was comparatively higher in the control group (p < 0.001) — 40 (39; 41) weeks. Neonatal encephalopathy as the main diagnosis occurred more often among full-term newborns (p < 0.001). Children of groups 1 and 2 did not differ significantly in the frequency of cases of respiratory distress syndrome and neonatal encephalopathy (p > 0.05). In group 2 compared to the first one, manifestations of NEC occurred significantly more often (p < 0.05): 9/30.0 ± 8.4 % vs 3/9.4 ± 5.2 %. We determined that the level of miR-148a expression in the BM of the mothers of premature children on BF was significantly lower (p < 0.001) than in the group of full-term children: 0.089 (0.048; 0.142) c.u. vs 1.0 (1.0; 1.0) c.u. Furthermore, the level of the transcription factor T-bet expression in the cells of the buccal mucosa scrapings was higher in premature children with clinical NEC (p = 0.022): 2.36 (1.94; 3.17) c.u. vs 1.49 (1.0; 3.27) c.u. in children without signs of NEC. We proved the presence of direct positive correlation between the T-bet level and NEC manifestations (r = 0.271; p = 0.021) and determined the inverse correlation between the level of miR-148a expression in the mother’s BM and the level of T-bet expression (r = –0.371; p = 0.043). Conclusions. The miR-148a expression level is relatively lower in the BM of the mothers whose children were born prematurely and have problems with adaptation than in the mothers who gave birth at term. However, in case of NEC development, there is an increase of miR-148a level in the mother’s BM, which contributes to a decrease in the T-bet expression in the mucous membranes of the child and has a protective impact on intestinal walls.
The role of miRNAs in the development of hepatobiliary diseases
Authors: Abaturov O.E. , Babуch V.L.
Published: March 2023

The role of miRNA in the development of hepatobiliary diseases is considered in the scientific review. To write the article, information was searched using Scopus, Web of Science, MedLine, PubMed, Google Scholar, EMBASE, Global Health, The Cochrane Library databases. The authors provided information on the generation of a certain spectrum of miRNA by different types of cells of the hepatobiliary system. The authors state that miR-122-5p, miR-101, miR-192, miR-193, miR-194, miR-802 are hepatocyte-associated microRNAs. It is known that numerous microRNAs are involved in the regulation of the inflammatory process: miR-21, miR-29a, miR-96, miR-122, miR-125b, miR-132, miR-155, miR-146a, miR-150, miR-155, miR-181 and let-7. Among the many microRNAs involved in the regulation of inflammation in the liver, miR-122 and miR-155 are the most studied. It is stated that microRNAs such as let-7d, miR-15b, miR-19b, miR-21, miR-24, miR-29c, miR-122, miR-145, miR-155, miR-199, miR-200c, miR-378a are the most important modulators for the activity of fibrosis development in various tissues of the body, including liver tissue. MicroRNAs involved in the development of TGF-β1-induced liver fibrosis are presented. Scientists believe that since microRNAs regulate the cell cycle, proliferation and apoptosis of cells, they are factors that significantly affect the development of hepatobiliary tumors. It is emphasized that changes in miRNA profile in liver tissue or blood serum have their diagnostic value. Modulations of microRNAs are shown, which are associated with specific diseases of the liver and biliary tract with a high degree of probability. Thus, various miRNAs play an important role in the development of hepatobiliary diseases. A certain spectrum of miRNAs is generated by different cell types and plays an important role in the maturation and functioning of the hepatobiliary system. MicroRNAs indirectly participate in the synthesis of proteins, differentiation of cells, tissues and play an important pathogenetic role in the development of hepatobiliary diseases. The most important feature of microRNAs is their high resistance to the action of enzymatic substances, which allows them to be used as diagnostic or prognostic biomarkers.
EVALUATION OF SYNERGISTIC EFFECT OF EVAPORATIVE COOLING SYSTEM AND POTASSIUM PERMANGANATE ON EXTENDING THE SHELF LIFE AND QUALITY OF PLANTAIN
Authors: SAMUEL OYEWOLE OMONIYI , K OGUNGBEMI , O ILORI A , O IBITOYE , BT AYANGBEMI
Published: March 2023

Background: Plantain is a climacteric fruit, which means that as it ripens, it increases its respiration rate and ethylene production. Therefore losses are recorded along its production chain value. Post-harvest loss is a major problem limiting the production of plantain in African due to unavailability of established storage conditions that can guarantee long shelf life. In the quest of extending the shelf life and quality of plantain, this study was carried out to evaluate the synergistic effect of Evaporative cooling system (ECS) and Potassium permanganate (KMnO4).
Methods: Unripe plantain fruit were stored under four different condition, ECS, KMnO4 only, ECS with KMnO4 and a control. The storage was done for a period of 12 days with laboratory analysis carried out through this period to analyze the quality of the stored fruits. The pH, weight loss, Total soluble solid (TSS), peel color, Total titratable acid, firmness test and dry matter was carried out.
Result: The pH, which is a major factor in determining the degree of ripening of fruit was obtained to be 4.85, 4.94, 5.00 and 5.77 for control, KMnO4, ECS and ECS with KMnO4 storage condition respectively. Also, the TSS which is also directly proportional to the degree of ripeness was recorded to be 24.00, 21.00, 12.10 and 10.80 for control, KMnO4, ECS and ECS with KMnO4 storage condition respectively. The least percentage weight loss was obtained in ECS with KMnO4 storage condition which is favorable to a better firmness result. 31%, 15.13% and 11.11% weight loss was obtained in control, KMnO4 and ECS storage condition. After day 6 of storage, the plantain fruits in ECS and ECS with KMnO4 ¬¬storage condition maintained their stage 1 characteristics as different from what was obtainable in control and KMnO4 storage. At the end of the storage period, the quality of the stored plantain fruits stored in ECS with KMnO4 was examined to be better in color, firmness, weight loss, pH, TSS and dry matter.
Conclusion: When compared to the individual performances of KMnO4 and ECS, it can be concluded that the synergistic effect further extend the shelf life and quality of plantain fruits.
GLOBAL HEALTH ISSUES WITH CONFLICT ESCALATION AMONG PANDEMIC, CLIMATE, AND ECONOMIC CRISES
Authors: MOHIUDDIN ABDUL KADER
Published: March 2023

Religion, governance, and politics - as well as related topics such as human rights, justice, and so on - have historically caused many of the world’s most significant conflicts, and they continue to do so because these issues are often the most fundamental in the structure of a society. To gain a military advantage, parties to armed conflicts have polluted water, burned crops, cut down forests, poisoned soils, and killed animals over the years. A variety of context factors, particularly socioeconomic conditions, governance, and political factors, interact and play a key role in translating climate change into conflict risks. The present unrest all over the world risks putting more than half of the countries into a crisis of health, economy, and social safety, which remains the most constant threat to human civilization. The security and safety of health-care facilities, workers, and supply lines remain paramount concerns, along with access to health services, technology, and innovation.
NETWORK PHARMACOLOGY AND MOLECULAR DOCKING TECHNIQUES TO EXPLORE THE PHARMACOLOGICAL MECHANISM OF CATECHINS AND THEIR DERIVATIVES AGAINST METABOLIC SYNDROME
Authors: RODRIGUES OLIVIA
Published: March 2023

Objective: Metabolic syndrome (MetS) is one of the most prevalent disorders in both industrialized and developing nations that it is characterized by a set of risk variables that encompass abdominal obesity, dyslipidemia, hypertension, and insulin resistance MetS constitutes a collective set of cardiometabolic attributes that raise the risk of type 2 diabetes mellitus and cardiovascular diseases. Catechins possess anti-inflammatory and antioxidant effects which may provide defense against many chronic diseases. The present study attempts to associate the pharmacological benefits of catechins and their derivates against MetS using in silico approaches.
Methods: Identification of the ligands and target proteins was done using drugbank and protein-protein interaction network stitch, respectively. The ligands and proteins were docked using pyrx and the docked complexes were visualized on BIOVIA to identify the potential ligand. ADMET analysis was done for the same ligands to study their pharmacological properties.
Results: The proteins glutathione peroxidase 1 and tumor protein P53 were identified as target proteins expressed in MetS which also showed effective docking results with the ligands hesperidin and gamma-tocopherol, respectively. The study’s findings concurred with those of earlier studies indicating that the derivatives of catechins such as hesperidin and gamma-tocopherol had potential benefits in the prognosis of MetS.
Conclusion: The investigation findings concluded that the ligands hesperidin and gamma-tocopherol may be therapeutic against MetS prevention and management.
MOLECULAR DOCKING AND INTERACTION OF COUMARIN DERIVATIVES AS INHIBITORS OF GROWTH FACTOR RECEPTORS
Authors: NAZEERULLA FAHIKA
Published: March 2023

Objective: Cancer is the largest cause of mortality in the globe, accounting for over 10 million deaths in 2020, or roughly one in every six. Because growth factor receptors are involved in the pathophysiology of the disease in several ways, human epidermal growth factors (HER-2 and HER-3) and vascular endothelial growth factor receptors (VEGFR-2 and VEGFR-3) might be as considered therapeutic targets. Coumarins and derivatives were chosen for this study to investigate their pharmacological characteristics and therapeutic effect against the targeted proteins implicated in the pathogenesis of different cancers.
Methods: In this work, 50 coumarins and their derivatives were chosen to assess their binding affinity with the targeted proteins (HER-2, HER-3, VEGFR-2, and VEGFR-3). PyRx, a virtual tool, was utilized to perform molecular docking. The investigation was carried out computationally, with data and molecular structures of the phytocompounds and proteins derived from Indian medicinal plants, phytochemistry, and therapeutics, as well as PubChem. The protein structure was validated using a variety of tools, including Protein Data Bank sum generate and BIOVIA discovery studio software. The pharmacological assessment of the ligands was carried out using ADMET filters.
Results: According to the results of molecular docking, the ligands Glycycoumarin, Mutisifurocoumarin, Thunberginol A, Pervilleanine, Licocoumarin A, and Murrayacoumarin C had the lowest binding affinity toward the four targeted proteins.
Conclusion: Since these compounds are effective against the growth factor receptors implicated in cancer pathogenesis, they could be a suitable candidate for cancer management and suppression. However, in vitro research is still required to support these findings.
IDENTIFICATION OF ANTI-CANCEROUS DRUGS FOR THE MUTATED SNAP25 PROTEIN RELATED TO BRAIN TUMOR THROUGH STRUCTURE-BASED VIRTUAL SCREENING APPROACH
Authors: PARASHAR POOJA , SHARMA SAMEER
Published: March 2023

Objective: Brain tumor is a formidable challenge for drug development, and drugs derived from many advanced technologies are being tested in clinical trials. Synaptosomal-associated protein of 25 kDa (SNAP25) is a membrane-binding protein in neurons and it is critical in neurotransmission for the fusion of plasma membrane and synaptic vesicle making it a prime target to address brain tumors. The SNAP-25 gene is responsible for personality disorders, schizophrenia, attention deficit, and hyperactivity disorder in human beings. It is recently discovered, that this protein is responsible for brain cancer as well.
Methods: In the present research, 17 investigational and experimental anticancer drugs were selected from the PubChem and DrugBank databases to identify potential inhibitors with high stability to treat mutated SNAP25 protein. For this purpose, we have used the structure-based virtual screening technique wherein, the candidate molecules are computationally docked into the 3D structure of the biological. The docking was achieved in PyRx 0.8 software and the drugs were then ranked based on their predicted binding affinity or complementarity to the binding site.
Results: Based on the ligand binding energy, the top six compounds having greater inhibitory effects towards SNAP25 were selected and then visualized with Pymol and Biovia visualizers. The compound Crenolanib has better pharmacological properties and demonstrated higher binding affinities with the target protein. Therefore, this Crenolanib docked confirmations were appraised for molecular dynamic simulations.
Conclusion: The study concluded that the anticancer drug Crenolanib exerted inhibitory potential against the mutated protein SNAP-25 and therefore it can be exploited as a cancer modulator to address brain tumors.
THE STUDY OF FURNITURE DESIGN (LAY OUT AND ERGONOMIC) DURING THE COVID-19 PANDEMIC AT DKI JAKARTA PUBLIC SERVICE MALL
Authors: ATMADI TUNJUNG
Published: March 2023

The problem currently faced is that changes in interior design styles during the COVID-19 pandemic have greatly affected the furniture design trend. With the current epidemic, we live in isolation that limits social interactions. We need to adapt to carry out daily activities, both indoors and outdoors. We do this so that we avoid exposure to the coronavirus. In this regard, the trend of furniture design inevitably has to change according to health protocols. DKI Jakarta Public Service Mall is one of the things that must improve with this. Public facilities, which are elements in the form of seats, have an important role in public service activities. Public furniture such as seats is an important thing whose function is to support comfort. The purpose of this research is to examine the layout and ergonomics. The research method used in this research study is a qualitative descriptive method, with layout analysis in the waiting room and human dimension analysis as well as posture analysis using the REBA method. The expected benefits in this research are the publication of the results of research and development through a National Journal accredited by Sinta, can achieve the expected Technology Readiness Level and convey the results of research to the Research Center of Mercu Buana University.
FACTORS INFLUENCING THE ADOPTION OF MOBILE FINANCIAL SERVICES IN ENHANCING FINANCIAL INCLUSION: USING STRUCTURAL EQUATION MODELING FOR THE DECISION-MAKING APPROACH
Authors: BASHIR BABA KURA , MUHAMMAD TIJJANI
Published: March 2023

The study aims to examine the relationship between mobile financial services and financial inclusion. Using modification hypotheses related to the technology acceptance model, the theory of Rational Behavior, and the Theory of Planned Behavior were adopted to test hypothesized relationships. The study employed a quantitative approach whereby 220 respondents participated in the survey online, accessing the view on mobile financial services in promoting financial inclusion. Convenience sampling was adopted to select appropriate and needed participants for the study. The study focused on the perception of the mobile users that use mobile banking regarding its usefulness as a banking service. The findings indicate social influence, performance expectancy, risk perception, and trust perception are significantly related to mobile financial services and enhance financial inclusion. The study found that the more mobile banking customers interact with devices, the more mobile financial services grow and accept innovations towards technology and convenient service, and the more likely they are to adopt it. The study contributed significantly to the existing body of knowledge through mobile financial services. The strength of the relationship between mobile financial services and financial inclusion through the independent variables. This provides essential insights and analysis that can influence the outcome of other relationships and the model. A notable limitation is the underestimation of the rural population in this study is significantly important. Future studies should provide larger rural samples of mobile banking users.
Development of an Employee Attendance System Using Face Recognition and QR-Code Technology
Authors: Oludayo Ogundele I. , Oluwatoyin Akinade A. , Foluso Akinsola A. , Eloho Ishola P.
Published: March 2023

Abstract: The procedure of recording attendance at any organization, including polytechnics and other institutions, is crucial to demonstrating why a particular employee is exceptional. Traditional attendance management systems, which use attendance sheets and signatures, have shown to have some associated issues, including time wastage, impersonation, and attendance sheet misplacement, making the system wasteful and unproductive. Appraising Non-academic staff in Yaba College of Technology has been a great challenge due to the aforementioned problem confronting the management to properly monitored the attendance system put in place with the traditional methods. To solve these problems, the study developed a computerized attendance system that implements face recognition and QR-code was designed and implemented using python programming language, MySQL server database, Tkinter framework was used to build the interface and Open Camera Vision (OpenCV) library. The algorithms for face detection and recognition include Haar cascasde algorithm and Local Binary Pattern Histogram (LBPH) algorithm respectively. The system is equipped with the capability to send instant email attendance reports to the management on daily, weekly or monthly basis. The result findings shows that there was 98.8% detection and recognition rates and 0.12% errors encountered for both face and QR-code. The highest read time was also measured to be 210.30ms. The result finding from our test shows the efficiency and effectiveness of the attendance system and it is therefore recommended for use in Yaba College of Technology for attendance monitoring of Non-academic staff for onward appraisal by the HOD, Dean and the college management.
Kelsen’s Pure Theory of Law: An Overview
Authors: Bisht Divya
Published: March 2023

Abstract: This paper deals with the origins of the many, frequently quite unfavourable, criticisms made of Kelson's pure theory of law and reveals key characteristics of several stages in its growth; point out the importance of Merkl and Verdross' work in developing the pure theory of law as well as the driving forces behind Kelsen's attempts to formalise jurisprudence (the science of law) in order to set the stage for an accurate and unbiased study of positive law; he also assesses the significance of Kelsen's normativisms and offers his opinions on how the pure theory of law should be developed going forward and its impact on legal system and its application along with the case analysis
A Survey on Market Based Economic Security Dispatch (MBESD) Policy in Supply Chain Power Market
Authors: Dey Basudeb
Published: March 2023

Abstract: Power System safety and financial dispatch is principal intention to restructuring of electricity system. Economizing on gas price and minimizing emission of gases (CO, CO2, NO2, SO2) are one approach of to maintained safety of machine however solely this system are no longer archived this label of security. Now in pandemic state of affairs when energy financial increase is falling down then it is very tough to maintained desirable device security. In this pandemic scenario country wide load dispatching centers play essential position to overcome this situation. This paper is excessive lightening and mentioned some new current procedural schemes. We are additionally put into effect a new idea (MBED).This paper is exposes special method to enhancement of Power Policies. This method shall be relevant to all thermal ISGS (Inter –State – Generating Station) that are regional entities collaborating in RRAS mechanism and whose tariff is decided or adopted with the aid of the CERC (Central Electricity Regulatory Commission) for their full capacity. Here we are mentioned all on the foundation of NLDC, RLDC, RPCS, SCED exclusive adopting schemes and comparative studies.
Design and Analysis of Quad Copter Chassis Using Shape Optimization Technique
Authors: Sreeramoju Srawanee , Rao M. Sreenivasa
Published: March 2023

Abstract: Unmanned aerial vehicles (UAVs) are replacing many traditional methods ranging from simple play toys to critical defense operations. UAVs or drones that are the little flying machines are used in space, defense, food delivery, pest sprays for agriculture, consumer goods delivery, land-surveillance and the list goes on. However, the physics behind it demands a lesser weight for drone to fly high as lesser the weight, lesser is the power required to operate. In all the components that make up a drone, is the frame that is most important structure which holds and bears everything at place. So the material used for the drone frame plays a very crucial role for it should have a lesser mass but sufficient strength. In this work, frame is modeled taking into consideration, its sturdiness and stress analysis is conducted using Autodesk Fusion 360 software and compared for different materials of frames from plastics to metals and the design is shape optimized to meet the objective
Application of Triple Active Bridge Converter for Future Grid and Integrated Energy System
Authors: Kondekar Anshamu G. , Dhande Asst. Prof. Nilima B. , Zade Asst. Prof. Dimpal U.
Published: March 2023

Abstract: Renewable energy systems and electric vehicles (EVs) are receiving much attention in industrial and scholarly communities owing to their roles in reducing pollutant emissions. Integrated energy systems (IES), which connect different types of renewable energies and storages, have become common in many applications, such as the grid-connected photovoltaic (PV) and battery systems, fuel cells and battery/super capacitor in EVs. The advantages of all energy sources are maximized by utilizing connection and control strategies. Because many storage systems and household loads are mainly direct current (DC) types, the DC grid has considerable potential for increasing the efficiency of distribution grids in the future. In IES and future DC grid systems, the triple active bridge (TAB) converter is an isolated bidirectional DC-DC converter that has many advantages as a core circuit. In this paper reviews the characteristics of the TAB converter in current applications and suggests nextgeneration applications. First, the characteristics and operation modes of the TAB converter are introduced. An overview of all current applications of the TAB converter is then presented. The advantages and challenges of the TAB converter in each application are discussed. Thereafter, the potential future applications of the TAB converter with an adaptable power transmission design are presented.
Seismic Behaviour PSC Box Girder and PSC Precast I Girder Bridge
Authors: Singh Narendra , Maru Dr. Savita
Published: March 2023

Abstract: Bridge is the structure that provide passage over an obstacle. The prestressed concrete bridges have excellent riding characteristics that minimize traffic vibrations, torsional rigidity, less likely to crack prematurely continuous span, strength and the most noteworthy characteristic is natural frequency of vibration hardly matches with vehicle frequency therefore attained spacious acceptance in freeway, highway flyovers, and in modern metro rail systems. As bridges are the important structures should be capable to withstand static as well as dynamic loads specially, earthquakeinduced load to achieve a structure that behave at the level of life safety under enormous earthquakes. There are different types of bridge structure base on material & geometric parameters, from which prestress concrete precast I girder bridge and box girder bridge are widely used for medium to long span rang. Box girder bridge are the bridge where the main beam consists of girder in hollow shape, where as in I girder bridge main beam consist of I-shape girder are used as main girder beam.
Analysis of Reciprocating Compressor Valve
Authors: Gupta Ankush S. , Thakare Prof. Neetesh N. , Gorantiwar Dr. Vinod S.
Published: March 2023

Abstract: A compressor running at even moderate speeds requires for each valve to open and close over one million times a day. It follows that valve design must bear in mind that it needs to be highly reliable and operate efficiently even in adverse conditions, such as in applications where there are liquids and debris in the gas stream. The fundamental challenge in the design of a compressor valve lies in the opening and closing phase of the valve, where an effort is made to allow for the most desirable dynamic behavior as possible. For instance, lowering the pressure loss across the valve by increasing the flow area leads to a higher possibility of unsuitable dynamic behavior and thus decreases its lifetime.This thesis is devoted to a theoretical study of reciprocating compressor valve dynamics. The analysis of the influence of the valve parameters on its dynamic behavior is also present in this thesis. This study has been undertaken in the compressor valve generally a flap valve and their CAD modelling with analysis of compressor valve equivalent stress, temperature and heat flux.
Thermal Energy Storage Capacity of Composite Solid Desiccant Used In Sun Drying Applications Using Paraffin Wax
Authors: R Mani , M Gowtham , S Hariharan , P Srinivasan , N Parthiban , V Ashokpandy , V Karthikeyan , P Manikandan
Published: March 2023

Abstract: Systems for storing thermal energy have become more important in solar thermal applications in order to supply the energy during overcast and gloomy hours. The capacity of a solid desiccant made up of 60% bentonite, 10% calcium chloride, 20% vermiculite, and 10% cement on a dry weight basis paired with a latent heat storage medium made of paraffin wax is examined in this study. Solid desiccant and paraffin have volume percentages of 90: 10, 80: 20, and 70: 30, respectively. The hollow cylindrical solid desiccant mould is filled with paraffin wax, which has a latent heat of fusion of 253 kJ/kg and a melting point of approximately 61.6 degrees Celsius. An experiment is conducted at air mass flow rate of 0.01, 0.02, and 0.03 kg/m2s with temperatures of 40, 50 and 60OC. The heat storage and retrieval capacity of 80% solid desiccant with 20% paraffin wax at 50oC and 0.02kg/m2s show the better results which are suitable for solar drying.
Development of Stability Indicating RP-HPLC Method for Tizanidine Hydrochloride in Bulk Drug and Pharmaceutical Dosage Form
Authors: Rani Rekha , Chaudhari Lokesh , Dhanorya Devendra , Ahirwar Damodar , Kori Shivam , Ahirwar Vinita , Raj Sashi , Kurmi Saraswati
Published: March 2023

The quantitative analysis of tizanidine hydrochloride in both pharmaceutical dosage form and bulk medication has been developed and validated using an easy, affordable, quick, and unique isocratic HPLC approach. Tizanidine hydrochloride was separated isocratically using Waters symmetry C18 ODS as the stationary phase (250×4.6 mm, 5μm particle size), a flow rate of 1.0 ml/min, and a UV detector to track the eluate at 230 nm. The drug and its degradation products could be separated using the mobile phase, which was made up of acetonitrile: phosphate buffer (20:80 v/v) and pH-adjusted to 3.0 by ortho-phosphoric acid. Linearity, accuracy (recovery), precision, specificity, and robustness of the approach were all validated. For the range of 4-80 μg/ml, the linearity of the technique was satisfactory (correlation coefficient 0.999). Between 100.4 to 101.3% of the tizanidine hydrochloride was recovered from the medicinal dosage form. In order to analyze the samples, tizanidine hydrochloride was put under stress conditions, including hydrolysis (acid, base), oxidation, photolysis, and heat degradation. The tizanidine hydrochloride forced degradation study demonstrated that it decomposed under minimal conditions. Under the other stress scenarios examined, the medication remained steady. It was discovered that tizanidine hydrochloride was significantly more stable in its solid state than in its solution condition. The breakdown products were clearly distinguishable from the primary peak.  The validation method may be useful for routine analysis of tizanidine hydrochloride as bulk drug, in respective dosage forms, for dissolution studies, and as a stability indicating assay method in pharmaceutical laboratories and industries because the forced degradation study proves the method's stability indicating power.

Keywords: RP-HPLC, Tizanidine hydrochloride, Forced degradation, Method validated
Total phenol content of accessions of Kencur (Kaempferia galanga L.) at different altitudes
Authors: Subaryanti Subaryanti , Triadiati Triadiati , Sulistyaningsih Yohana Caecilia , Pradono Dyah Iswantini
Published: March 2023

Kencur (Kaempferia galanga L.) is one of the potential medicinal plants with a high enough market demand so that the cultivation of kencur is still quite promising. The purpose of this study was to analyze the effect of altitude on the total phenol content of several accessions of kencur. The research was carried out at the Tropical Biopharmaceutical Laboratory, Bogor Agricultural University, from June to November 2017. The treatment tested was kencur accession rhizome taken from two altitudes, 214 m asl (lowlands) and 780 m asl (highlands). 10 g of kencur accession rhizome powder was added with methanol in a ratio of 1:10, then macerated while shaking using a magnetic stirrer (25 °C; 180 min). The extract was filtered and the filtrate was dried using a rotary vacuum evaporator (50 rpm; 60 °C) until a dry crude extract was obtained. Total phenol was tested by the Folin-Ciocalteu method at a wavelength of 730 nm. The results showed that altitude significantly affected the total phenol content of the kencur accession rhizome extract. The highest total phenol content value was obtained from Galesia 1 (GAL 1) in the lowlands of 17.92 mg/g (equivalent to gallic acid/GAE) and in the highlands obtained from PBG accession (Purbalingga) of 24.85 GAE mg/g compared to other accessions.
Physical and chemical conditions of waters for seaweed cultivation in Morowali, Central Sulawesi, Indonesia
Authors: Yala Zakirah Raihani
Published: March 2023

This study was aimed to examine the physical and chemical conditions of the seaweed growing areas in Morowali Regency. It was carried out in January–August 2019 in 13 sub-districts of Morowali Regency, however the sample was taken from 3 sub-districts, South Bungku District, Witaponda District, and Petasia District, because not all districts have seaweed cultivation locality. Data sampling was done in three observation stations, consisting of several research sub-stations. The result showed that only two of the fourteen criteria—carbon dioxide and nitrate—were found to be unfavorable for seaweed growth at three observation stations.
Formulation and Physical Evaluation of Sunscreen Cream with Methanol Extract of Euchema cottonii
Authors: Wulansari Devi , Aripudin  , Ratnaningtyas Susi , Gopurullah Sri Suminar
Published: March 2023

Seaweed has been widely used as a traditional medicinal ingredient by the community for generations. One species of seaweed, Eucheuma cottonii, is known that contains many antioxidant compounds. The antioxidant in seaweed is mainly in the form of polyphenolic antioxidative compounds, especially flavonoids. Flavonoid and tannin are two compounds that perform as antioxidant activity and have been considered as potential sunscreen ingredients.

The test methods used in this study include SPF value determination test, sensitivity test, homogeneity test, pH test, and viscosity test. Sensitivity test was conducted by 20 semi-trained panelists. The data was statistically analyzed using one-way ANOVA SPSS version 21.0.
Sensitivity and Specificity of Molecular-Based Pathogen Detection Method in Refillable Drinking Water Samples
Authors: Achyar Afifatul , Putri Irma Leilani Eka , Putri Dwi Hilda
Published: March 2023

The existence of refillable drinking water depots helps the community to get affordable and practical drinking water. However, poor quality drinking water will, however, have an effect on health. One of the quality parameters of drinking water that is suitable for consumption is not contaminated by the bacteria Escherichia coli, Salmonella sp. and Escherichia sp. Measurement of the quality of drinking water, in addition to microbiological tests, can be carried out molecularly using PCR (Polymerase Chain Reaction) method. Therefore, the aim of this study was to examine the sensitivity and specificity of PCR for detection of drinking water pathogens. DNA was extracted from cultures of E. coli, Salmonella sp., Escherichia sp. and some non-coliform bacteria. PCR was performed separately using primer pairs of E. coli-AA-Forward and E.coli-AA-Reverse, Salmonella-OY-Forward and Salmonella-OY-Reverse, E. coli-DB-Forward and E. coli-DB-Reverse. The results of the PCR sensitivity showed that the minimum amount of DNA that can be detected by this method were 0.0025 ng/µL, 0,0005 ng/µL, 0,04 ng/µL for E. coli, Salmonella sp., Escherichia sp., respectively. The results of the PCR specificity of each primer pairs indicated that these methods were able to detect each coliform bacterium specifically according to PCR product size of ± 417 bp, ± 559 bp and ± 815 bp for E. coli, Salmonella sp., Escherichia sp., respectively.
Analisis Kinerja Jaringan Irigasi Ogoamas 1, Kecamatan Sojol Utara, Kabupaten Donggala
Authors: Rivaldi R. , Sutapa I.W.
Published: March 2023

Irrigation performance is influenced by several aspects, namely: physical infrastructure, crop productivity, supporting facilities and infrastructure, personnel organization, documentation, and water user farmer associations (P3A). The purpose of this study was to determine the performance of the irrigation network in the Ogoamas 1 Irrigation Area based on the Regulation of the Minister of Public Works No.12/PRT/M/2015. The research method was carried out by direct survey to the location, interviews and documenting the irrigation network to obtain primary and secondary data. secondary. After that, data analysis was carried out. From the results of the analysis it can be concluded that the weight value of the physical infrastructure condition is 33.21%, the condition of crop productivity is 10.40%, the condition of supporting facilities is 8.75%, the personnel organization condition is 11.40%, the documentation condition is 3.80. %, and the P3A condition is 6.15%. The result of the overall weight value of the performance of the Ogoamas 1 irrigation network is 73.71% with good performance category.
Analisis Tingkat Kebisingan Lalu Lintas pada Kawasan Kampus 1 Universitas Negeri Gorontalo Ditinjau dari Tingkat Baku Mutu Kebisingan yang Diizinkan
Authors: Mopili C. , Kadir Y. , Mahmud M.
Published: March 2023

An increase in traffic volume causes several negative impacts, one of which is noise. The Campus 1 area of the State University of Gorontalo is one of the education zones where the traffic flow is quite heavy, so a study was conducted to analyze the noise level due to traffic in the area and compare the noise level with the Noise Quality Standard KEP-48/MENLH/11/1996. This research was conducted on roads adjacent to Campus 1 State University of Gorontalo, namely on the roads Jenderal Sudirman (point 1) with road type 2/2 UD, the roads Ir. Hi. Joesoef Dalie (point 2) with road type 4/2 D, and the roads Dewi Sartika (point 3) with road type 2/2 UD. The method used is called "Calculation of Road Traffic Noise (CoRTN). The highest noise level on the road General Sudirman (point 1) is 69,36 dB(A) on Monday, 69,56 dB(A) on Wednesday, and 67,74 dB(A) on Saturday. On Monday, the highest noise level on the roads of Ir. Hi. Joesoef Dalie (point 2) is 72,28 dB(A), on Wednesday, 72,69 dB(A), and on Saturday, 69,90 dB(A). The highest noise level on the road Dewi Sartika is 67,77 dB(A) on Monday, 67,41 dB(A) on Wednesday, and 67,57 dB(A) on Saturday. These results indicate that the noise level in the Campus 1 area of the State University of Gorontalo has exceeded the permitted noise quality standard according to the Decree of the State Minister of the Environment No. 48 of 1996 concerning the noise quality standard for educational areas, which is 55 dB (A).
Estimasi Emisi Kendaraan Ringan pada Ruas Jalan Perintis Kemerdekaan Kota Makassar
Authors: Patunrangi S.N.J. , Kadir A.I.N.K. , Sutrisno M.
Published: March 2023

Population growth is increasingly demanding economic growth accompanied by the need for transportation as facilities of movement person and goods. The increase of transport it is not balanced with the right policies will cause various problems appertain the increasing number of motorized vehicles that has an impact on the environment, namely increasing air pollution. Exhaust emissions from motorized vehicles originating from fossil fuels make impact the environment. Various studies on transportation models have been developed by many researchers, various transportation models can also estimate emissions from motorized vehicles included MOVES and IVEM. The aim of this study is to analyze whether there are differences between the results of the emission estimation model in the MOVES and IVEM programs. The method used is using a driving cycle, where the vehicle is tracking on the highway using GPS second per second. Tracking is carried out on the Perintis Kemerdekaan road with a starting point of KM 7.75 to the end point of KM 13.12 as well as for the opposite direction. Tracking done at peak hours of 7-10 am, 11-14 noon, and 11-14 afternoon. The results showed that the concentration of Nox emissions was higher in the MOVES model data analysis than the IVEM model, as the CO emission concentration in the morning and evening was higher in the MOVES model and the CO emission concentration during the day was higher in the IVEM model. Statistically with the t test, the result is 0.13 where the result of the CO concentration for the MOVES and IVEM models are the same and for the t test the NOx concentration is 0.008 that the results of the analysis of the IVEM and MOVES models for NOx are not the same.
Kajian Perilaku Kuat Geser Tanah Terhadap Penambahan Serat Karung Goni
Authors: Martini M. , Fadliah I. , Biru B.
Published: March 2023

Soil improvement is a method to improve the physical and mechanical properties of soil that are not good. Soil improvement methods include chemical, mechanical, hydraulic, and reinforcement methods for example by adding geosynthetic sheets/fibers or steel rods. However, the use of these methods is relatively quite expensive from the aspect of the materials used when applied to small-scale volume work. This research tries to examine the behavior of the soil that is given the addition of jute sack fiber, especially to changes in shear strength/soil shear strength parameters. Jute sacks are an alternative material as a substitute for fiber of the Geosynthetic type, jute sacks have a rough texture made of jute fiber, where jute fiber is the second most used natural fiber after cotton. Jute fiber itself can be taken from the bark of the bast fiber tree. Jute itself is an environmentally friendly fabric because it is made from bio-degradable fibers and is included in fabrics made of 100% plant fibers. The percentage of jute fiber used was 0.25%, 0.50% and 0.75% of the dry weight of the soil with variations in length of 1.5 cm, 2.0 cm and 2.5 cm. The sample of soil tested is sandy type  from the permanent residential area of Tondo, Mantikulore sub-district, Palu, Central Sulawesi. The addition of fiber has more effect on changes in the value of the soil friction angle than the value of cohesion. Jute fibers with lengths of 1.5 cm and 2.5 cm at percentages between 0.25% and 0.75% tend to increase, but at 2 cm length tend to decrease the value of shear strength. Fiber length and burlap percentage influence each other in increasing and decreasing the value of soil shear strength
Kajian Sistem Drainase Perumahan di Kota Luwuk Kabupaten Banggai
Authors: Suartana P.
Published: March 2023

Luwuk City is the center of the city of Banggai Regency, which continues to grow. Urban development is followed by an increase in population and land requirements. Changes in land use from open land such as forests, gardens and dry fields to land for settlements causes surface water infiltration to decrease and increase surface runoff. Increased runoff due to reduced water catchment areas as the impact of city development has caused existing drainage to not be able to accommodate the increasing runoff water, resulting in waterlogging or even flooding. About 80% of the water used by the community is discharged directly as liquid waste into drainage canals. This condition of the community results in the accumulation of waste or silt in the drainage channels. This study aims to examine the drainage system in Luwuk City. The study was carried out by evaluating the existing canal system and identifying the suitability of the primary and secondary canals. Based on the results of the analysis carried out in this study, there are several things that can be concluded, namely: several drainage paths indicate the direction of flow does not follow the topography so that this can cause waterlogging and there are 3 natural channels that can be used as primary drainage and 6 natural channels that can be used as secondary drainage so that it will help speed up the flow of water to the final storage area
Analisis Struktur Baja dengan Perhitungan Beban Gempa Menggunakan Metode Time History Berdasarkan SNI 1726:2012 dan SNI 1729:2015
Authors: Turu’allo G. , Anggara A.H.
Published: March 2023

The selection of material types used in designing a building is one of essential parts since every type of material consisted of different elements. One of primary materials in constructing building structure is steel. The use of steel has been implemented in most building structures nowadays for its high performance of ductility compared to concrete and wood. Ductility is an important requirement to achieve building structure that is resistant to earthquake. In this thesis, there will be an elaboration of an earthquake resistant and steel structured building. The designed building will be a five-floor office configured by an organized structure. The steel framework system of specialized moment loader is used as structure system of earthquake resistance and analysed using time history method. The steel material used has A36 grade (fy = 250 MPa; fu = 400 MPa), and the concrete grade f’c = 30 MPa. The preparation process results in a design of an earthquake steel resistant structure building that meets the requirement of intersection between each floor and the maximum intersection value occurs on second floor with 93,5 mm where the legal supposed intersection has been valued on 95 mm. The dimension of structure element used is profile block W 14 x 6,75 x 38 for the x-axis and W 16 x 7 x 40 for y-axis. It also has 12 cm of plate thickness on every level with profile column of Wx14x16x283
Model Bangkitan Perjalanan Masyarakat Penyintas di Kota Palu (Studi Kasus : Hunian Tetap Tondo 1)
Authors: Rahman R. , Mashuri M. , Labaso E.R. , Hildayanti H.
Published: March 2023

Tondo 1 permanent housing is intended for residents affected by the earthquake and tsunami on 28 September 2018. Furthermore, Tondo 1 permanent housing is now inhabited by people from various areas such as Petobo, Mamboro, Balaroa, Talise, and Tondo Villages. The rapid population growth in the tondo village after the relocation resulted in increased movements in the tondo village due to a large number of trips. This affects the trip generation of people who travel from their homes to the Central Business District (CBD) to carry out their daily activities. This study aims to determine the community's characteristics and model the trip generation in Tondo 1 permanent housing. This study used the multiple linear regression method. Based on the calculation, two variables affect the trip: the number of working family members (X2) and the number of vehicle ownership (X5). Therefore, the analysis model of the trip generation of survivors at Tondo 1 permanent housing area is obtained as follows: Y = 1.766 + 0.325 X2 + 0.271 X5.