bluuebunny/crossref_metadata_2025 huggingface dataset:
Prefrontal attentional saccades explore space rhythmically
Authors: Gaillard Corentin , Ben Hadj Hassen Sameh , Di Bello Fabio , Bihan-Poudec Yann , VanRullen Rufin , Ben Hamed Suliann
Published: May 2019

Recent studies suggest that attention samples space rhythmically through oscillatory interactions in the frontoparietal network. However, the precise mechanism through which the prefrontal cortex, at the source of attention control signals, organizes this rhythmic exploration of space remains unknown. We show that, when decoded at a high spatial (0.1°) and temporal resolution (50ms), the prefrontal covert attentional spotlight, aka the mind’s eye, continuously explores space at an alpha 7-12 Hz rhythm. When sensory events are presented at a specific optimal phase (resp. anti-phase) with respect to this rhythm, sensory encoding and behavioral report are accurate (resp. poor). We propose that this rhythmic prefrontal attentional spotlight dynamics corresponds to a continuous overt exploration of space via alpha-clocked attentional saccades. These attentional saccades are highly flexible, their pattern of space exploration depending both on within-trial and across-task contingencies. These results are discussed in the context of exploration and exploitation strategies and prefrontal top-down attentional control.

Highlights

The decoded prefrontal attentional spotlight samples visual space in rhythmic cycles

This rhythmic attentional exploration predicts neuronal sensory processing accuracy

This rhythmic attentional exploration predicts overt behavioral accuracy

These rhythmic cycles define alpha-clocked attentional saccades

Space exploration by attentional saccades is highly flexible and under top-down control
Characterization of a regulatory T cells molecular meta-signature identifies the pro-enkephalin gene as a novel marker in mice
Authors: Aubert Nicolas , Salomon Benoit L. , Marodon Gilles
Published: May 2019

Regulatory T cells (Treg) are crucial in the proper balance of the immune system. A better characterization of Treg-specific genes should extend our knowledge on their complex biology. However, to date there is no consensual Treg signature in the literature. Here, we extracted a molecular Treg meta-signature relative to CD4+ conventional T cell from 8 different but comparable publicly available microarray datasets. We confirmed the validity of our result using the much larger but less stringent Immuno-Navigator database. However, many genes of the Treg meta-signature were also expressed at the protein level by other immune cell subsets, as assessed by mass cytometry, with the noticeable exceptions of Il2ra, Ctla4, and Tnfrsf9. Surprisingly, the proenkephalin (Penk) gene was a prominent member of this restricted Treg meta-signature. Further analysis of public datasets and of our own RNA sequencing experiments confirms that Penk was over expressed by Treg in various murine tissues, including thymic Treg. Interestingly, Penk expression was increased in intra tumoral Treg whereas it was down modulated in the central nervous system of mice suffering from EAE. Finally, we propose a mechanistic model linking TNFR signaling and the transcription factor Batf in the regulation of Penk expression in Treg. Altogether, our results provide the first Treg meta-signature in mice and identifies Penk as a novel and unexpected Treg marker.
BaRTv1.0: an improved barley reference transcript dataset to determine accurate changes in the barley transcriptome using RNA-seq
Authors: Rapazote-Flores Paulo , Bayer Micha , Milne Linda , Mayer Claus-Dieter , Fuller John , Guo Wenbin , Hedley Pete E , Morris Jenny , Halpin Claire , Kam Jason , McKim Sarah M. , Zwirek Monika , Casao M. Cristina , Barakate Abdellah , Schreiber Miriam , Stephen Gordon , Zhang Runxuan , Brown John WS , Waugh Robbie , Simpson Craig G
Published: May 2019

Background

Time consuming computational assembly and quantification of gene expression and splicing analysis from RNA-seq data vary considerably. Recent fast non-alignment tools such as Kallisto and Salmon overcome these problems, but these tools require a high quality, comprehensive reference transcripts dataset (RTD), which are rarely available in plants.

Results

A high-quality, non-redundant barley gene RTD and database (Barley Reference Transcripts – BaRTv1.0) has been generated. BaRTv1.0, was constructed from a range of tissues, cultivars and abiotic treatments and transcripts assembled and aligned to the barley cv. Morex reference genome (Mascher et al., 2017). Full-length cDNAs from the barley variety Haruna nijo (Matsumoto et al., 2011) determined transcript coverage, and high-resolution RT-PCR validated alternatively spliced (AS) transcripts of 86 genes in five different organs and tissue. These methods were used as benchmarks to select an optimal barley RTD. BaRTv1.0-Quantification of Alternatively Spliced Isoforms (QUASI) was also made to overcome inaccurate quantification due to variation in 5’ and 3’ UTR ends of transcripts. BaRTv1.0-QUASI was used for accurate transcript quantification of RNA-seq data of five barley organs/tissues. This analysis identified 20,972 significant differentially expressed genes, 2,791 differentially alternatively spliced genes and 2,768 transcripts with differential transcript usage.

Conclusion

A high confidence barley reference transcript dataset consisting of 60,444 genes with 177,240 transcripts has been generated. Compared to current barley transcripts, BaRTv1.0 transcripts are generally longer, have less fragmentation and improved gene models that are well supported by splice junction reads. Precise transcript quantification using BaRTv1.0 allows routine analysis of gene expression and AS.
The Energetics of Molecular Adaptation in Transcriptional Regulation
Authors: Chure Griffin , Razo-Mejia Manuel , Belliveau Nathan M. , Einav Tal , Kaczmarek Zofii A. , Barnes Stephanie L. , Lewis Mitchell , Phillips Rob
Published: May 2019

Mutation is a critical mechanism by which evolution explores the functional landscape of proteins. Despite our ability to experimentally inflict mutations at will, it remains difficult to link sequence-level perturbations to systems-level responses. Here, we present a framework centered on measuring changes in the free energy of the system to link individual mutations in an allosteric transcriptional repressor to the parameters which govern its response. We find the energetic effects of the mutations can be categorized into several classes which have characteristic curves as a function of the inducer concentration. We experimentally test these diagnostic predictions using the well-characterized LacI repressor of Escherichia coli, probing several mutations in the DNA binding and inducer binding domains. We find that the change in gene expression due to a point mutation can be captured by modifying only a subset of the model parameters that describe the respective domain of the wild-type protein. These parameters appear to be insulated, with mutations in the DNA binding domain altering only the DNA affinity and those in the inducer binding domain altering only the allosteric parameters. Changing these subsets of parameters tunes the free energy of the system in a way that is concordant with theoretical expectations. Finally, we show that the induction profiles and resulting free energies associated with pairwise double mutants can be predicted with quantitative accuracy given knowledge of the single mutants, providing an avenue for identifying and quantifying epistatic interactions.

We present a biophysical model of allosteric transcriptional regulation that directly links the location of a mutation within a repressor to the biophysical parameters that describe its behavior. We explore the phenotypic space of a repressor with mutations in either the inducer binding or DNA binding domains. Using the LacI repressor in E. coli, we make sharp, falsifiable predictions and use this framework to generate a null hypothesis for how double mutants behave given knowledge of the single mutants. Linking mutations to the parameters which govern the system allows for quantitative predictions of how the free energy of the system changes as a result, permitting coarse graining of high-dimensional data into a single-parameter description of the mutational consequences.
Activation loop dynamics are controlled by conformation-selective inhibitors of ERK2
Authors: Pegram Laurel M. , Liddle Jennifer C. , Xiao Yao , Hoh Maria , Rudolph Johannes , Iverson Dylan B. , Vigers Guy P. , Smith Darin , Zhang Hailong , Wang Weiru , Moffat John G. , Ahn Natalie G.
Published: May 2019

Modulating the dynamics of protein kinases expands the inhibitory mechanisms for small molecules. NMR measurements of the MAP kinase, ERK2, have shown that activation by dual-phosphorylation induces global motions involving exchange between two states, “L” and “R”. We show that ERK inhibitors Vertex-11e and SCH772984 exploit the small energetic difference between L and R to shift the equilibrium in opposing directions, while inhibitor GDC-0994 and ATP analogue AMP-PNP retain L⇌R exchange. An X-ray structure of active 2P-ERK2 complexed with AMP-PNP reveals a shift in the Gly-rich loop along with domain closure to position the nucleotide in a more catalytically productive conformation relative to inactive 0P-ERK2:ATP. X-ray structures of 2P-ERK2 complexed with Vertex-11e or GDC-0994 recapitulate this closure, which is blocked in a complex with a SCH772984 analogue. Thus, the L→R shift in 2P-ERK2 is associated with movements needed to form a competent active site. Solution measurements by hydrogen-exchange mass spectrometry (HX-MS) reveal distinct binding modes for Vertex-11e, GDC-0994 and AMP-PNP to active vs inactive ERK2, where the extent of HX protection matches their degree of R-state formation. In addition, Vertex-11e and SCH772984 show opposite effects on HX near the activation loop, suggesting that L⇌R exchange involves coupling between the activation loop and the active site. Consequently, these inhibitors differentially affect MAP kinase phosphatase activity towards 2P-ERK2. We conclude that global motions in ERK2 promote productive nucleotide binding, and couple with the activation loop to allow control of dephosphorylation by conformation-selective inhibitors.

SIGNIFICANCE STATEMENT

Protein kinases in the RAF/MKK/ERK signaling pathway are dysregulated in cancer and are important targets for inhibitor development. Catalytic activation of the MAP kinase, ERK2, induces global motions involving exchange between two conformational states. Using nuclear magnetic resonance (NMR) and hydrogen-exchange mass spectrometry, we show that inhibitors exploit these motions to trap ERK2 in distinct states. Our findings reveal motions of the activation loop coupled to the active site. Inhibitor binding can control these activation loop dynamics to alter its rate of dephosphorylation by MAP kinase phosphatase.
Synthesis, structural characterization, EPR spectroscopy and Hirshfeld surface analysis of a novel Cu2+-doped 3,14-diethyl-2,13-diaza-6,17-diazoniatricyclo[16.4.0.07,12]docosane bis(perchlorate)
Authors: Moncol Jan , Mazúr Milan , Valko Marian , Choi Jong-Ha
Published: May 2019

Cyclam derivatives and their metal complexes have been found to exhibit an anti-HIV effect and stimulate the activity of stem cells from bone marrow. The strength of their binding to the CXCR4 receptor correlates with anti-HIV and stem-cell activities. Knowledge of the conformation and crystal packing of various macrocyclic metal complexes has become important in developing new effective anti-HIV drugs. The synthesis and preparation of single crystals of a new Cu2+-doped macrocyclic compound, (3,14-diethyl-2,6,13,17-tetraazatricyclo[16.4.0.07,12]docosane)copper(II) bis(perchlorate)–3,14-diethyl-2,13-diaza-6,17-diazoniatricyclo[16.4.0.07,12]docosane bis(perchlorate) (0.69/0.31), {[Cu(C22H44N4)](ClO4)2}0.69·(C22H46N4
2+·2ClO4
−)0.31, is reported. Characterization by X-ray diffraction analysis shows that the asymmetric unit contains half of a centrosymmetric molecule. The macrocyclic ligand in the compound adopts the most stable trans-III conformation. The Cu—N distances of 2.015 (3) and 2.047 (3) Å are normal, but the long axial Cu—O bond of 2.795 (3) Å may be due to a combination of the Jahn–Teller effect and the strong in-plane ligand field. The crystal structure is stabilized by hydrogen bonding between secondary N—H groups, the N atoms of the macrocycle and the O atoms of the perchlorate anions. Hirshfeld surface analysis with 2D (two-dimensional) fingerprint plots indicates that the main contributions to the crystal packing are from H...H (58.0%) and H...O/O...H (41.9%) interactions. Electron paramagnetic resonance (EPR) properties are also described.
Bis[S-benzyl 3-(furan-2-ylmethylidene)dithiocarbazato-κ2
N
3,S]copper(II): crystal structure and Hirshfeld surface analysis
Authors: Yusof Enis Nadia Md , Nasri Nazhirah Muhammad , Ravoof Thahira B. S. A. , Jotani Mukesh M. , Tiekink Edward R. T.
Published: May 2019

The title CuII complex, [Cu(C13H11N2OS2)2], features a trans-N2S2 donor set as a result of the CuII atom being located on a crystallographic centre of inversion and being coordinated by thiolate-S and imine-N atoms derived from two dithiocarbazate anions. The resulting geometry is distorted square-planar. In the crystal, π(chelate ring)–π(furyl) [inter-centroid separation = 3.6950 (14) Å and angle of inclination = 5.33 (13)°] and phenyl-C—H...π(phenyl) interactions sustain supramolecular layers lying parallel to (\overline{1}02). The most prominent interactions between layers, as confirmed by an analysis of the calculated Hirshfeld surface, are phenyl-H...H(phenyl) contacts. Indications for Cu...Cg(furyl) contacts (Cu...Cg = 3.74 Å) were also found. Interaction energy calculations suggest the contacts between molecules are largely dispersive in nature.
Crystal structure, Hirshfeld surface analysis and HOMO–LUMO analysis of (E)-N′-(3-hydroxy-4-methoxybenzylidene)nicotinohydrazide monohydrate
Authors: Sivajeyanthi Palaniyappan , Edison Bellarmin , Balasubramani Kasthuri , Premkumar Ganesan , Swu Toka
Published: May 2019

The molecule of the title Schiff base compound, C14H13N3O3·H2O, displays a trans configuration with respect to the C=N bond. The dihedral angle between the benzene and pyridine rings is 29.63 (7)°. The crystal structure features intermolecular N—H...O, C—H...O, O—H...O and O—H...N hydrogen-bonding interactions, leading to the formation of a supramolecular framework. A Hirshfeld surface analysis indicates that the most important contributions to the crystal packing are from H...H (37.0%), O...H/H...O (23.7%)), C...H/H...C (17.6%) and N...H/H...N (11.9%) interactions. The title compound has also been characterized by frontier molecular orbital analysis.
Crystal structure and Hirshfeld surface analysis of (Z)-6-[(2-hydroxy-4-methylanilino)methylidene]-4-methylcyclohexa-2,4-dien-1-one
Authors: Kansiz Sevgi , Aydin Alev Sema , Dege Necmi , Agar Erbil , Fritsky Igor O.
Published: May 2019

The title compound, C15H15NO2, is a Schiff base that exists in the keto–enamine tautomeric form and adopts a Z configuration. The molecule is almost planar, with the two phenyl rings twisted relative to each other by 9.60 (18)°. There is an intramolecular N—H...O hydrogen bond present forming an S(6) ring motif. In the crystal, pairs of O—H...O hydrogen bonds link adjacent molecules into inversion dimers with an R
2
2(18) ring motif. The dimers are linked by very weak π–π interactions, forming layers parallel to (\overline{2}01). Hirshfeld surface analysis, two-dimensional fingerprint plots and the molecular electrostatic potential surfaces were used to analyse the intermolecular interactions, indicating that the most important contributions for the crystal packing are from H...H (55.2%), C...H/H...C (22.3%) and O...H/H...O (13.6%) interactions.
Development of hybrid method for coupled conduction-radiation heat transfer in two-dimensional irregular enclosure considering thermo-radiative effects and varying thermal conductivity
Authors: Zare Mehdi , Sadeghi Sadegh
Published: May 2019

Purpose

This study aims to perform a comprehensive investigation to model the thermal characteristics of a coupled conduction-radiation heat transfer in a two-dimensional irregular enclosure including a triangular-shaped heat source.

Design/methodology/approach

For this purpose, a promising hybrid technique based on the concepts of blocked-off method, FVM and DOM is developed. The enclosure consists of several horizontal, vertical and oblique walls, and thermal conductivity within the enclosure varies directly with temperature and indirectly with position. To simplify the complex geometry, a promising mathematical model is introduced using blocked-off method. Emitting, absorbing and non-isotropic scattering gray are assumed as the main radiative characteristics of the steady medium.

Findings

DOM and FVM are, respectively, applied for solving radiative transfer equation (RTE) and the energy equation, which includes conduction, radiation and heat source terms. The temperature and heat flux distributions are calculated inside the enclosure. For validation, results are compared with previous data reported in the literature under the same conditions. Results and comparisons show that this approach is highly efficient and reliable for complex geometries with coupled conduction-radiation heat transfer. Finally, the effects of thermo-radiative parameters including surface emissivity, extinction coefficient, scattering albedo, asymmetry factor and conduction-radiation parameter on temperature and heat flux distributions are studied.

Originality/value

In this paper, a hybrid numerical method is used to analyze coupled conduction-radiation heat transfer in an irregular geometry. Varying thermal conductivity is included in this analysis. By applying the method, results obtained for temperature and heat flux distributions are presented and also validated by the data provided by several previous papers.
Employment and skill mismatch among youth in Lebanon
Authors: Dibeh Ghassan , Fakih Ali , Marrouch Walid
Published: May 2019

Purpose

Employment and skill mismatch among youth constitute a major obstacle for access to the job market in the Middle East and North African region. The purpose of this paper is to explore factors explaining employment and the perception of the skill-mismatch problem among the youth in Lebanon using a novel data set covering young people aged from 15 to 29. The paper provides a set of empirical insights that help in the design of public policy targeting school-to-work transition.

Design/methodology/approach

The authors control for a rich set of youth and household characteristics to jointly estimate the probability of being employed and the likelihood of reporting a skill-mismatch problem. The empirical analysis uses a bivariate probit model where the first equation estimates the employment status while the second estimates the determinants of skill-mismatch perceptions. The bivariate probit model considers the error terms in both equations to be correlated and the model tests for such a correlation. The authors estimate the model recursively by controlling for the employment dummy variable in the skill-mismatch equation since employed youth could be more or less likely to perceive the skill mismatch. The estimation is conducted first over the whole sample of youth, and then it is implemented by gender and region.

Findings

The authors find that youth employment is mainly correlated with age, being male, being single, having received vocational training and financial support from parents, living with parents and receiving current education. The skill-mismatch perceptions are mainly driven by being male, being single, having received post-secondary education and belonging to upper and middle social classes. The authors also find that employability level and skill-mismatch problems are jointly determined in the labor market for males and in the core region only.

Originality/value

The paper covers a country that is neglected in the literature on the employment-skill mismatch nexus in the context of school-to-work transition. The study also uses a novel data set focusing on youth. The paper contributes to our understanding of the school-to-work transition in particular and to the youth-to-adulthood transition in general.
Examining an integrative model of resilience, subjective well-being and commitment as predictors of organizational citizenship behaviours
Authors: Paul Happy , Bamel Umesh , Ashta Ashok , Stokes Peter
Published: May 2019

Purpose

A review of the emerging scholarly literature on positive organizational scholarship indicates a need to pursue cognitive, emotional and motivational mechanisms which translate into positive states and outcomes in organizations. Responding to this, this paper aims to test a mediation model linking resilience and organizational citizenship behaviors (OCB) through subjective well-being (SWB) components (i.e. life satisfaction and affect balance) and organizational commitment (OC) components.

Design/methodology/approach

Data were collected from 345 employees working in the Indian manufacturing industry. The study used structural equation modeling using AMOS to conduct bootstrapped mediation analyses.

Findings

Results showed that SWB and OC components mediated the resilience-OCB relationship. Results offered strong support for the role of affect balance (high positive and low negative affect) and affective commitment in mediating the influence of resilience on OCB.

Originality/value

The study not only tested the applicability of resilience in an organizational context to predict coveted positive outcomes but also identified the underlying mechanism as how psychological resource capacities like resilience contribute to OCBs.
Key challenges to digital financial services in emerging economies: the Indian context
Authors: Rana Nripendra P. , Luthra Sunil , Rao H. Raghav
Published: May 2019

Purpose

Digital financial services (DFS) have substantial prospect to offer a number of reasonable, appropriate and secure banking services to the underprivileged in developing countries through pioneering technologies such as mobile phone based solutions, digital platforms and electronic money models. DFS allow unbanked people to obtain access to financial services through digital technologies. However, DFS face tough challenges of adoption. Realising this, the purpose of this paper is to identify such challenges and develop a framework.

Design/methodology/approach

The authors developed a framework of challenges by utilising interpretive structural modelling (ISM) and fuzzy MICMAC approach. The authors explored 18 such unique set of challenges culled from the literature and further gathered data from two sets of expert professionals. In the first phase, the authors gathered data from 29 professionals followed by 18 professionals in the second phase. All were pursuing Executive MBA programme from a metropolitan city in South India. The implementation of ISM and fuzzy MICMAC provided a precise set of driving, linkage and dependent variables that were used to derive a framework.

Findings

ISM model is split in eight different levels. The bottom level consists of a key driving challenge V11 (i.e. high cost and low return related problem), whereas the topmost level consists of two highly dependent challenges namely V1 (i.e. risk of using digital services) and V14 (i.e. lack of trust). The prescribed ISM model shows the involvement of “high cost and low return related problem (V11)”, which triggers further challenges of DFS.

Originality/value

None of the existing research has explored key challenges to DFS in detail nor formulated a framework for such challenges. To the best of the authors’ knowledge, this is the first paper on DFS that attempts to collate its challenges and incorporate them in a hierarchical model using ISM and further divide them into four categories of factors using fuzzy MICMAC analysis.
The impact of principles-based vs rules-based accounting standards on reporting quality and earnings management
Authors: Sundvik Dennis
Published: May 2019

Purpose

The purpose of this paper is to explore whether principles-based vs rules-based accounting standards have an effect on measures of financial reporting quality and earnings management strategies.

Design/methodology/approach

This study uses a firm-year-specific variable that captures the extent to which firms’ accounting and operating behavior is affected by the characteristics of a specific standard in the USA. Measures of absolute accruals, financial misconducts, signed abnormal accruals and abnormal cash flows are used to assess the effects.

Findings

The results show that absolute magnitude of accruals and probability of financial misconduct is lower, and accrual earnings management is higher when firms’ standards are more based on principles. The study also suggests that potentially costlier real earnings management is a consequence of rules-based standards.

Research limitations/implications

This study relies heavily on measures from the prior accounting literature, hence, care has been exercised in generalizing the findings.

Practical implications

This study has direct implications for a number of stakeholders, including standard setters, policymakers, securities regulators, researchers, investors, financial statement preparers and auditors. For example, the future development of accounting standards can be supported by the empirical conclusions in this study together with previous standard-setting ambitions, commentaries, experiments and analytical work.

Originality/value

This study extends prior single-country studies on reporting quality and cross-country studies on transition effects of firms switching from local to International Accounting Standards by observing the impact of accounting standard characteristics on additional measures of reporting quality and accrual as well as real earnings management when holding institutional factors constant. The study also offers archival evidence complementing prior commentaries, experiments and analytical work.
The dynamics of financial information and non-financial environmental, social and governance information in the strategic decision-making process
Authors: Esch Martin , Schulze Mike , Wald Andreas
Published: May 2019

Purpose

The purpose of this paper is to link the fields of research on strategic decision (SD) making and integrated reporting (IR) and advances knowledge of the concept of integrated thinking by describing how financial information and non-financial environmental, social and governance (ESG) information are used in different phases of the strategic decision-making process (SDMP).

Design/methodology/approach

In total, 15 senior executives from twelve different industries were asked about the importance of different types of information within SDMPs. The data were analyzed by means of content analysis.

Findings

The authors derive a four-phase model and explicate the utilization of financial information and non-financial ESG information within each phase. The findings show that both types of information affect SDMPs, but the importance of each type differs among the phases.

Practical implications

This study offers practitioners a yardstick against which to compare how they use different types of information throughout the SDMP.

Originality/value

This paper provides a conceptual model of integrated thinking in SD making by connecting two separate fields of research. This connection will permit deeper study of the field of information and its implications for SD making. The present investigation shows that IR can promote integrated thinking in companies, as the broader range of information at hand allows companies to form a holistic picture of internal management questions and incorporate information that has not been previously prepared or associated with existing information.
Employee creativity in a digital era: the mediating role of social media
Authors: Korzynski Pawel , Paniagua Jordi , Rodriguez-Montemayor Eduardo
Published: May 2019

Purpose

The purpose of this paper is to investigate how the use of social media can facilitate employee creativity. Departing from theories on social capital and knowledge management, this study examines the relationship among individual characteristics, the use of social technologies and employee creativity. The main hypothesis of the study is that online social networking mediates the relationship between personal innovativeness and creativity.

Design/methodology/approach

Data were obtained through an online survey of 80 engineers and 12 managers working in a large IT company listed by the Fortune 500 (n1=80,n2=12). The empirical strategy relies on fixed-effects structural equation modeling and confirmatory factor analysis with a quasi-experimental design to study the structural relationship among creativity, online social connectivity (OSC) and personal innovativeness.

Findings

The study provides three major findings. First, the results show that personal innovativeness regarding new technologies is positively associated with creativity. Second, 18 percent of the association between personal innovativeness and creativity is explained by the latent mediator OSC (a construct of online networking and knowledge management). More specifically, the partial mediation is driven by online networking, specifically establishing new connections. Finally, contrary to the expectations, there is no significant evidence that the relationship between creativity and personal innovativeness is mediated by online social knowledge management.

Practical implications

Understanding the ways in which online connections and online knowledge management as well as personal innovativeness are related to employee creativity helps in building innovative organizations. This study may facilitate recruitment and selection strategies and encourage organizations to implement platforms with user-friendly functionalities of connecting with other employees and searching data.

Originality/value

The main question of this study is whether all features related to social technologies make people more creative. Evidence is still scarce, but there are hints that creativity is not only an innate personal feature but also a social phenomenon. This study explains the benefits of OSC for enhancing employee creativity.
Performance appraisal satisfaction and turnover intention
Authors: Memon Mumtaz Ali , Salleh Rohani , Mirza Muhammad Zeeshan , Cheah Jun-Hwa , Ting Hiram , Ahmad Muhammad Shakil
Published: May 2019

Purpose

The purpose of this paper is to examine the impact of performance appraisal satisfaction (PAS) on work engagement (WE) and the impact of WE on turnover intention. Furthermore, this paper investigates the mediating effect of WE between PAS and turnover intention.

Design/methodology/approach

The sample consisted of employees of 12 oil and gas organisations operating in Malaysia. The data collection process consists of two surveys using a three-month time lag approach. A total of 295 samples were used for the final data analysis. Partial least squares structural equation modelling was performed to test the research hypotheses.

Findings

The results indicate a strong causal relation between PAS, WE and turnover intentions. In brief, PAS was found to be a predictor of WE, and WE has a negative impact on employees’ turnover intention. Furthermore, WE proved to be a mediator between PAS and turnover intentions.

Practical implications

The findings of this study can be used as a basis to consider PAS to increase employees’ level of WE and to decrease voluntary turnover. Overall, the findings provide pragmatic insights for human resource management practitioners and relevant stakeholders.

Originality/value

To date, little is known about the interrelationship between PAS, WE and turnover intention. Importantly, the mediating role of WE between PAS and turnover intention has remained unexplored. This study fills this gap in the existing literature.
Knowledge management in entrepreneurial universities
Authors: Secundo Giustina , Ndou Valentina , Del Vecchio Pasquale , De Pascale Gianluigi
Published: May 2019

Purpose

The purpose of this paper is to review and critique the knowledge management (KM) literature within Entrepreneurial universities, providing an overview of the state of research and outlining a future research agenda.

Design/methodology/approach

In a systematic literature review, 1106 articles indexed at Scopus were initially submitted to a bibliometric analysis. Finally, 150 papers published in a variety of academic journals specializing in the field of Entrepreneurship, KM and Higher Education were analyzed through a content and a bibliometric analysis to minimize mistakes in interpreting findings of collected studies.

Findings

KM within entrepreneurial university is a research area of growing importance. Findings show that literature on KM models and tools in the entrepreneurial university is fragmented and dominated by unrelated research. Content analysis shows heterogeneous literature, but four major research streams emerge: knowledge transfer in university–industry collaboration; knowledge creation in entrepreneurship education; KM processes for university spin-offs; entrepreneurial university to support knowledge-based regional development. The results show a failure to address the implications of findings for policy makers, which risks making KM in entrepreneurial universities research irrelevant.

Research limitations/implications

Although different structured literature reviews (SLRs) exist separately in the field of KM and entrepreneurial universities, to the authors’ best knowledge, no studies exist in the intersection between the two fields.

Originality/value

The paper presents the first attempt to provide a comprehensive SLR of the articles dealing with models and processes of KM in the entrepreneurial university. Despite the increasing literature, this research area is still fragmented and undertheorized, thus requiring more systematic and holistic studies, considering both the economic and the social aspects of KM within universities. The paper’s findings can offer insights into future research avenues.
Magnetohydrodynamic flow of molybdenum disulfide nanofluid in a channel with shape effects
Authors: Raza Jawad , Mebarek-Oudina Fateh , Chamkha A.J.
Published: May 2019

Purpose

The purpose of this paper is to examine the combined effects of thermal radiation and magnetic field of molybdenum disulfide nanofluid in a channel with changing walls. Water is considered as a Newtonian fluid and treated as a base fluid and MoS2 as nanoparticles with different shapes (spherical, cylindrical and laminar). The main structures of partial differential equations are taken in the form of continuity, momentum and energy equations.

Design/methodology/approach

The governing partial differential equations are converted into a set of nonlinear ordinary differential equations by applying a suitable similarity transformation and then solved numerically via a three-stage Lobatto III-A formula.

Findings

All obtained unknown functions are discussed in detail after plotting the numerical results against different arising physical parameters. The validations of numerical results have been taken into account with other works reported in literature and are found to be in an excellent agreement. The study reveals that the Nusselt number increases by increasing the solid volume fraction for different shapes of nanoparticles, and an increase in the values of wall expansion ratio α increases the velocity profile f′(η) from lower wall to the center of the channel and decreases afterwards.

Originality/value

In this paper, a numerical method was utilized to investigate the influence of molybdenum disulfide (MoS2) nanoparticles shapes on MHD flow of nanofluid in a channel. The validity of the literature review cited above ensures that the current study has never been reported before and it is quite new; therefore, in case of validity of the results, a three-stage Lobattoo III-A formula is implemented in Matlab 15 by built in routine “bvp4c,” and it is found to be in an excellent agreement with the literature published before.
A study of prominence for disposition effect: a systematic review
Authors: Zahera Syed Aliya , Bansal Rohit
Published: May 2019

Purpose

The purpose of this paper is to study the disposition effect that is exhibited by the investors through the review of research articles in the area of behavioral finance. When the investors are hesitant to realize the losses and quick to realize the gains, this phenomenon is known as the disposition effect. This paper explains various theories, which have been evolved over the years that has explained the phenomenon of disposition effect. It includes the behavior of individual investors, institutional investors and mutual fund managers.

Design/methodology/approach

The authors have used the existing literatures from the various authors, who have studied the disposition effect in either real market or the experimental market. This paper includes literature over a period of 40 years, that is, Dyl, 1977, in the form of tax loss selling, to the most recent paper, Surya et al. (2017). Some authors have used the PGR-PLR ratio for calculating the disposition effect in their study. However, some authors have used t-test, ANNOVA, Correlation coefficient, Standard deviation, Regression, etc., as a tool to find the presence of disposition effect.

Findings

The effect of disposition can be changed for different types of individual investors, institutional investors and mutual funds. The individual investors are largely prone to the disposition effect and the demographic variables like age, gender, experience, investor sophistication also impact the occurrence of the disposition effect. On the other side, the institutional investors and mutual funds managers may or may not be affected by the disposition effect.

Practical implications

The skilled understanding of the disposition effect will help the investors, financial institutions and policy-makers to reduce the adverse effect of this bias in the stock market. This paper contributes a detailed explanation of disposition effect and its impacts on the investors. The study of disposition effect has been found to be insufficient in the context of Indian capital market.

Social implications

The investors and society at large can gains insights about causes and influences of disposition effect which will be helpful to create sound investment decisions.

Originality/value

This paper has complied the 11 causes for the occurrence of disposition effect that are found by the different authors. The paper also highlights the impact of the disposition effect in the decision-making of various investors.
Fair premium rate of the deposit insurance system based on banks’ creditworthiness
Authors: Yoshino Naoyuki , Taghizadeh-Hesary Farhad , Nili Farhad
Published: May 2019

Purpose

Deposit insurance is a key element in modern banking, as it guarantees the financial safety of deposits at depository financial institutions. It is necessary to have at least a dual fair premium rate system based on creditworthiness of financial institutions, as considering singular premium system for all banks will have moral hazard. This paper aims to develop theoretical and empirical model for calculating dual fair premium rates.

Design/methodology/approach

The definition of a fair premium rate in this paper is a rate that covers the operational expenditures of the deposit insuring organization, provides it with sufficient funds to enable it to pay a certain percentage share of deposit amounts to depositors in case of bank default and provides it with sufficient funds as precautionary reserves. To identify and classify healthier and more stable banks, the authors use credit rating methods that use two major dimensional reduction techniques. For forecasting nonperforming loans (NPLs), the authors develop a model that can capture both macro shocks and idiosyncratic shocks to financial institutions in a vector error correction model.

Findings

The response of NPLs/loans to macro shocks and idiosyncratic innovations shows that using a model with macro variables only is insufficient, as it is possible that under favorable economic conditions, some banks show negative performance due to bank level reasons such as mismanagement or vice versa. The final results show that deposit insurance premium rate needs to be vary based on banks’ creditworthiness.

Originality/value

The results provide interesting insight for financial authorities to set fair deposit insurance premium rate. A high premium rate reduces the capital adequacy of individual financial institutions, which endangers the stability of the financial system; a low premium rate will reduce the security of the financial system.
Autonomous mobile robot navigation between static and dynamic obstacles using multiple ANFIS architecture
Authors: Pandey Anish , Kashyap Abhishek Kumar , Parhi Dayal R. , Patle B.K.
Published: May 2019

Purpose

This paper aims to design and implement the multiple adaptive neuro-fuzzy inference system (MANFIS) architecture-based sensor-actuator (motor) control technique for mobile robot navigation in different two-dimensional environments with the presence of static and moving obstacles.

Design/methodology/approach

The three infrared range sensors have been mounted on the front, left and right side of the robot, which reads the forward, left forward and right forward static and dynamic obstacles in the environment. This sensor data information is fed as inputs into the MANFIS architecture to generate appropriate speed control commands for right and left motors of the robot. In this study, we have taken one assumption for moving obstacle avoidance in different scenarios the speed of the mobile robot is at least greater than or equal to the speed of moving obstacles and goal.

Findings

Graphical simulations have designed through MATLAB and virtual robot experimentation platform (V-REP) software and experiments have been done on Arduino MEGA 2560 microcontroller-based mobile robot. Simulation and experimental studies demonstrate the effectiveness and efficiency of the proposed MANFIS architecture.

Originality/value

This paper designs and implements MANFIS architecture for mobile robot navigation between a static and moving obstacle in different simulation and experimental environments. Also, the authors have compared this developed architecture to the other navigational technique and found that our developed architecture provided better results in terms of path length in the same environment.
Crumbs protein homolog 3 (CRB3) expression is associated with oestrogen and progesterone receptor positivity in breast cancer
Authors: Li Pingping , Zhou Can , Yan Yu , Li Juan , Liu Jie , Zhang Yan , Liu Peijun
Published: May 2019

The crumbs protein homolog 3 (CRB3) regulates the tight junction to help maintain epithelial polarity. Altered CRB3 expression was associated with carcinogenesis of epithelial cells. This study detected CRB3 expression in 192 cases of breast cancer tissues and in the Molecular Taxonomy of Breast Cancer International Consortium (Metabric) and The Cancer Genome Atlas (TCGA) datasets for association with triple negative breast cancer (TNBC) phenotypes. The in vitro experiments confirm the ex vivo data. The data showed that levels of both CRB3 mRNA and protein were associated with TNBC phenotypes, ie, 41.1% (39/95) of ER+ breast cancer was CRB3‐positive, whereas 26.9% (25/93) ER– tumour was CRB3‐positive (P = 0.046). Moreover, 47.6% (30/63) of PR+ breast cancer was CRB3‐positive vs 28.4% (33/116) PR‐ tumours positive for CRB3 (P = 0.013). In addition, 40.1% (27/66) of ER+/PR+ tumour was CRB3‐positive, but only 22.4% (19/85) of TNBC showed CRB3 expression (P = 0.048). Indeed, levels of CRB3 mRNA were higher in non‐TNBC than TNBC in both Metabric (P = 3.682e‐10) and TCGA datasets (P = 2.501e‐07). The in vitro data showed that CRB3 expression was higher in luminal (MCF7 and T47D) than in HER2 (MDA‐MB‐453 and SK‐BR‐3) and basal (MDA‐MB‐231 and BT‐549) breast cancer cell lines. More interestingly, ERα regulated expression of CRB3 protein in MCF7 and BT‐549 cells and ERα expression was associated with CRB3 expression in breast cancer tissues specimens. This study demonstrated that ERα could be a novel regulator for CRB3 expression in breast cancer.
Bromination of alkyl quinolones by Microbulbifer sp. HZ11, a marine Gammaproteobacterium, modulates their antibacterial activity
Authors: Ritzmann Niklas H. , Mährlein Almuth , Ernst Simon , Hennecke Ulrich , Drees Steffen L. , Fetzner Susanne
Published: May 2019

Alkyl quinolones (AQs) are multifunctional bacterial secondary metabolites generally known for their antibacterial and algicidal properties. Certain representatives are also employed as signalling molecules of Burkholderia strains and Pseudomonas aeruginosa. The marine Gammaproteobacterium Microbulbifer sp. HZ11 harbours an AQ biosynthetic gene cluster with unusual topology but does not produce any AQ‐type metabolites under laboratory conditions. In this study, we demonstrate the potential of strain HZ11 for AQ production by analysing intermediates and key enzymes of the pathway. Moreover, we demonstrate that exogenously added AQs such as 2‐heptyl‐1(H)‐quinolin‐4‐one (referred to as HHQ) or 2‐heptyl‐1‐hydroxyquinolin‐4‐one (referred to as HQNO) are brominated by a vanadium‐dependent haloperoxidase (V‐HPOHZ11), which preferably is active towards AQs with C5–C9 alkyl side chains. Bromination was specific for the third position and led to 3‐bromo‐2‐heptyl‐1(H)‐quinolin‐4‐one (BrHHQ) and 3‐bromo‐2‐heptyl‐1‐hydroxyquinolin‐4‐one (BrHQNO), both of which were less toxic for strain HZ11 than the respective parental compounds. In contrast, BrHQNO showed increased antibiotic activity against Staphylococcus aureus and marine isolates. Therefore, bromination of AQs by V‐HPOHZ11 can have divergent consequences, eliciting a detoxifying effect for strain HZ11 while simultaneously enhancing antibiotic activity against other bacteria.
Amphibian skin fungal communities vary across host species and do not correlate with infection by a pathogenic fungus
Authors: Medina Daniel , Hughey Myra C. , Walke Jenifer B. , Becker Matthew H. , Pontarelli Katherine , Sun Shan , Badgley Brian , Belden Lisa K.
Published: May 2019

Amphibian population declines caused by the fungus Batrachochytrium dendrobatidis (Bd) have prompted studies on the bacterial community that resides on amphibian skin. However, studies addressing the fungal portion of these symbiont communities have lagged behind. Using ITS1 amplicon sequencing, we examined the fungal portion of the skin microbiome of temperate and tropical amphibian species currently coexisting with Bd in nature. We assessed cooccurrence patterns between bacterial and fungal OTUs using a subset of samples for which bacterial 16S rRNA gene amplicon data were also available. We determined that fungal communities were dominated by members of the phyla Ascomycota and Basidiomycota, and also by Chytridiomycota in the most aquatic amphibian species. Alpha diversity of the fungal communities differed across host species, and fungal community structure differed across species and regions. However, we did not find a correlation between fungal diversity/community structure and Bd infection, though we did identify significant correlations between Bd and specific OTUs. Moreover, positive bacterial–fungal cooccurrences suggest that positive interactions between these organisms occur in the skin microbiome. Understanding the ecology of amphibian skin fungi, and their interactions with bacteria will complement our knowledge of the factors influencing community assembly and the overall function of these symbiont communities.