bluuebunny/crossref_metadata_2025 huggingface dataset:
Perinatal outcome of immigrant women with and without refugee status compared to non-immigrant women: results of the pregnancy and obstetric care for refugees (PROREF) cross-sectional study
Authors: Schlothauer Darja , Teschemacher Louise , Breckenkamp Jürgen , Borde Theda , David Matthias , Abou-Dakn Michael , Henrich Wolfgang , Seidel Vera
Published: August 2024

Purpose

International studies show conflicting evidence regarding the perinatal outcome of immigrant women with and without refugee status compared to non-immigrant women. There are few studies about the situation in Germany. The research question of this article is: Is the perinatal outcome (Apgar, UApH (umbilical artery pH), NICU (neontatal intensive care unit) transfer, c-section rate, preterm birth, macrosomia, maternal anemia, higher degree perinatal tear, episiotomy, epidural anesthesia) associated with socio-demographic/clinical characteristics (migration status, language skills, household income, maternal education, parity, age, body mass index (BMI))?

Methods

In the Pregnancy and Obstetric Care for Refugees (PROREF)-study (subproject of the research group PH-LENS), funded by the German Research Foundation (DFG), women giving birth in three centers of tertiary care in Berlin were interviewed with the modified Migrant Friendly Maternity Care Questionnaire between June 2020 and April 2022. The interview data was linked to the hospital charts. Data analysis was descriptive and logistic regression analysis was performed to find associations between perinatal outcomes and migration data.

Results

During the research period 3420 women (247 with self-defined (sd) refugee status, 1356 immigrant women and 1817 non-immigrant women) were included. Immigrant women had a higher c-section rate (36.6% vs. 33.2% among non-immigrant women and 31.6% among women with sd refugee status, p = 0.0485). The migration status did not have an influence on the umbilical artery pH, the preterm delivery rate and the transfer of the neonate to the intensive care unit. Women with self-defined refugee status had a higher risk for anemia (31.9% vs. 26.3% immigrant women and 23.4% non-immigrant women, p = 0.0049) and were less often offered an epidural anesthesia for pain control during vaginal delivery (42.5% vs. 54% immigrant women and 52% non-immigrant women, p = 0.0091). In the multivariate analysis maternal education was explaining more than migration status.

Conclusion

Generally, the quality of care for immigrant and non-immigrant women in Berlin seems high. The reasons for higher rate of delivery via c-section among immigrant women remain unclear. Regardless of their migration status women with low degree of education seem at increased risk for anemia.
Heterarchical modelling of comminution for rotary mills: part I—particle crushing along streamlines
Authors: Bisht Mukesh Singh , Guillard François , Shelley Paul , Marks Benjy , Einav Itai
Published: August 2024

Rotary mills aim to effectively reduce the size of particles through a process called comminution. Modelling comminution in rotary mills is a challenging task due to substantial material deformation and the intricate interplay of particle kinematics of segregation, mixing, crushing, and abrasion. Existing particle-based simulations tend to provide predictions that cannot cope with the large number of particles within rotary mills, their wide range of sizes, and the physics dictating the crushing of individual particles. Similarly, there is currently no deterministic modelling means to determine the evolving population of particle sizes at any point in time and space within the mill. The aim of this two-part contribution is to address these gaps by advancing a framework for a novel stochastic comminution model for rotary mills, which has a well-defined deterministic continuum limit and can cope with arbitrarily large numbers of particles. This work describes the basic physics and structure of the new model within a heterarchical framework for ball and autogenous grinding mills. The primary focus of this Part I paper is to develop a computational model for the integration of motion of material along streamlines inside a mill. Coupled to this process is the kinetic physics dictating particle crushing. In a subsequent work, Part II, segregation and mixing will be added to this model such that realistic behaviour from the mill can be observed.

Graphical Abstract
Heterarchical modelling of comminution for rotary mills: part II—particle crushing with segregation and mixing
Authors: Bisht Mukesh Singh , Guillard François , Shelley Paul , Marks Benjy , Einav Itai
Published: August 2024

In granular media, the crushing of individual particles is influenced by the number of contacts with neighbouring particles. This well-known phenomenon of “cushioning” shields the individual particles from crushing when the number of contacts is high. However, in open systems that involve extensive granular flow and bulk motion, like those found in industrial mills, the neighbouring particles continually exchange positions due to segregation and mixing, thereby altering the number of neighbouring contacts and their sizes, affecting the crushing of individual particles. Therefore, a critical challenge for properly modelling comminution in such systems lies in tracking the fluxes of the various particle size classes. Here, we explore the physics that governs the mechanisms of segregation and mixing within the multiscale heterarchical modelling paradigm. Building upon the framework developed in Part I, which integrated the heterarchical aspects of the physics of crushing along streamlines, we further account for segregation and mixing, and demonstrate their impact on the comminution efficiency of autogenous grinding mills. In particular, segregation is shown to greatly enhance the extent of particle crushing within the mill. Accordingly, we posit that this mechanism cannot be ignored. In summary, the new model sheds light on previously obscured dynamics within industrial mills, as well as enables the field to predict the time evolution of the particle size distribution at any point in the mill domain. This modelling capability opens the doors to new developments for estimating and improving milling efficiencies.

Graphical Abstract
Short-term effects of clearing restoration on the relationship of plant and moth communities
Authors: Piccini Irene , Pittarello Marco , Barberis Davide , Lonati Michele , Bonelli Simona , Scalercio Stefano
Published: August 2024

Insects and plants share a close relationship; plants provide feeding opportunities, ecological niches, and shelters for insects, while insects, in turn, facilitate pollination for plants. Management actions might positively or negatively affect insect species richness and/or abundance, in particular, forest practices can significantly influence insect communities. In this study, we investigated the effects on plant and moth communities following the realization of an ecological corridor (composed of 10 clearings) in forest in NW of Italy. Specifically, through plant surveys and moth light traps, we investigated plant and moth communities and their relationship in newly shaped clearings and their surrounding forest. We found that plants responded quickly to clearing formation, presenting differentiated plant communities between xero-thermophile clearings, mesophile clearings and forest. These differences reflected on moth communities as well, allowing to find indicator species for each ecosystem. Structural variables (i.e. openness) and topography (i.e. elevation) were key factors affecting the differentiation of moth communities. On the other hand, plants explained most of the variance in moth communities, so, through plants, we differentiated moth communities into those typical of xero-thermophile clearings, mesophile clearings and forest. In conclusion, forest management significantly affects plant and moth communities. Newly shaped clearings support higher species richness (including specialist species) and abundance than closed canopy forest. To increase species richness and abundance for both plants and moths, we suggest conservation measures that include creating open habitats within forests at medium elevation (650–950 m a.s.l.).
Association of reduced peak left atrial strain with supraventricular arrhythmia in adults with congenital heart disease
Authors: Nussbaumer Clément , Schwerzmann Markus , Elchinova Elena , Goulouti Eleni , Tobler Daniel , Greutmann Matthias , Wustmann Kerstin , Papa Andrea , Schwitz Fabienne
Published: August 2024

Atrial arrhythmias are an important cause of morbidity and mortality in adults with congenital heart disease (ACHD). In acquired heart disease, the left atrial (LA) strain has been shown to predict supraventricular tachyarrhythmias (SVT). This study aimed to investigate whether reduced LA strain is associated with SVT in ACHD patients. This retrospective, single-center cohort study collected baseline clinical and echocardiographic data of 206 ACHD patients (157 left heart defect, 49 right heart defect). Patients with sinus rhythm at baseline and a 5-year follow-up (median age 29, IQR 22–41 years) were included. Diagnosis of sustained SVT was determined from clinical reports during the follow-up period. New or recurrent sustained SVT occurred in 16 patients (7.8%, median follow-up of 6.2 years). Patients who developed SVT were older, more likely to have diastolic dysfunction, and had larger LA dimensions, left ventricular mass, and a lower peak LA longitudinal strain (PALS). Lower PALS was associated with higher risk of SVT in patients with left and right heart defects. Patients in the lowest quartile for PALS had a 15.9-fold higher hazard ratio of SVT (95% confidence interval, 4.5 to 56.0, p < 0.001) in comparison with the top three quartiles. PALS provides information about the occurrence of SVT in the ACHD population. Including measurement of LA strain in the follow-up of these patients may allow to better identify patients at risk of future atrial arrhythmias.

Graphical abstract
The Elementary Organisms
Authors: Brücke Ernst , Liu Daniel
Published: August 2024

In 1861 the physiologist Ernst Brücke (1819–1892) published “The Elementary Organisms,” calling for a major reform of the definition of the animal cell. An English translation of Brücke’s essay is presented here for the first time. In this translation the numbered footnotes 1–9 are Brücke’s own; alphabetical endnotes A–HH are my own annotations, with additional references to works cited by Brücke. Figures referenced by Brücke but not included in his original essay are also provided. I have also presented an introductory essay to my translation that provides background on Brücke and his arguments: “The Schema and Organization of the Cell,” https://doi.org/10.1007/s10739-024-09774-8, in this same issue of the Journal of the History of Biology.
Eco-Friendly Synchronous Spectrofluorimetric Method for Simultaneous Determination of Remdesivir and Acetyl Salicylic Acid in Spiked Human Plasma
Authors: aboelghar Sohair M. , Hegazy Maha A. , Wagdy Hebatallah A.
Published: August 2024

Remdesivir and acetyl salicylic acid are often co-administered medications in the treatment of COVID-19, specifically targeting the viral infection and thromboembolism associated with the condition. Hence, it is essential to establish a technique that enables the concurrent quantification of these pharmaceutical compounds in plasma while also keeping environmentally friendly methods. Accordingly, the aim of this work is to simultaneously determine remdesivir and acetyl salicylic acid through a bioanalytical validated synchronous spectrofluorimetric method with applying principles of green chemistry. Since, the two drugs showed severe overlap after excitation at 242.0 nm, 284.0 nm for remdesivir and acetyl salicylic acid, respectively. The overlap was effectively overcome by using synchronous mode with a wavelength difference (Δλ) of 160.0 nm for remdesivir and 100.0 nm for acetyl salicylic acid. Different parameters have been optimized such as Δλ, solvent, pH and surfactant. A linear calibration was obtained over the concentration range 0.01–4.00 µg/mL for remdesivir and 0.01–3.00 µg/mL for acetyl salicylic acid and the method was precise and accurate. The method was successfully used for the investigation of pharmaceutical formulation and the quantification of the maximum plasma concentration (Cmax) of the two drugs. The method has been evaluated as an excellent green analytical method based on three greenness assessment tools.
Characteristics of strong ground motions and structural damage patterns from the February 6th, 2023 Kahramanmaraş earthquakes, Türkiye
Authors: Akinci Aybige , Dindar Ahmet Anil , Bal Ihsan E. , Ertuncay Deniz , Smyrou Eleni , Cheloni Daniele
Published: August 2024

On February 6th, 2023, two severe earthquakes struck southeastern Türkiye near the Syrian border. The first earthquake, Mw7.8, occurred at 04:17 local time in the East Anatolian Fault Zone near the city of Gaziantep. The second earthquake, Mw7.5, occurred approximately 9 h later at 13:24 local time near Elbistan County, in Kahramanmaraş province. These seismic events ruptured multiple segments of the East Anatolian Fault Zone (EAFZ), with rupture lengths exceeding 300 km, and deformation exceeding 5 m on both sides of the faults. In this study, we aim to analyze characteristics of the strong ground motion induced by the mainshocks, focusing on ground motion intensity measures such as the peak ground acceleration (PGA), the peak ground velocity (PGV), and the pseudo-acceleration response spectra (PSA). The first earthquake produced extremely high PGA values in both horizontal (> 2 g) and vertical (> 1 g) components. At near field distances, large PGVs are measured (> 180 cm/s) with more than 30 impulsive motions which may indicate source-related effects. Large spectral demands are also recorded for both earthquakes, partially underestimated by Ground Motion Models (GMMs), especially in the near-field. Specifically, we compare the PSA for horizontal directions with the design spectra provided by both the new and previous Turkish building codes. We also present building and ground damage observations that provide insights into the observed ground motions in the heavily damaged areas.
Dendrogeomorphological analysis of a debris flow in the Monarch Butterfly Biosphere Reserve, central Mexico
Authors: De La Peña Guillén Karla Aurora , Mendoza Manuel E. , Carlon Allende Teodoro , Macías José Luis , Villanueva Díaz José
Published: August 2024

Debris flows are one of the most hazardous and frequent landslides in mountainous regions. In this research, we apply dendrogeomorphological techniques to analyze the debris flow that occurred in February 2010 in the Monarch Butterfly Biosphere Reserve in central Mexico. Firstly, analyzed precipitation data from two nearby meteorological stations has indicated that an extraordinary precipitation event accumulated 236.4 mm of rainfall over a 5-day period, from January 31st to February 4th, 2010. In addition, we generated a geomorphological cartography of the area at 1:600 scale by interpreting the images obtained using an Unmanned Aerial Vehicle. Subsequently, we carried out dendrochronological sampling on 98 Abies religiosa trees (125 cores); the cores were dated using cross-dating and the ring width was measured for generating a chronology, in which the years with growth disturbances as a result of the debris flow could be identified and characterized. We identified three types of growth anomalies in the tree ring series: (a) traumatic resin ducts, (b) growth suppression, and (c) growth releases, related to the 2010 debris flow event. We also estimated the debris flow intensity through the scar heights recorded in the trees, which allowed us to identify that the intensity of the debris flow was greater in the transport zone. These results highlight the benefit of the dendrogeomorphological technique used in the collection of spatio-temporal information on debris flow activity in intertropical montane environments, especially where information about mass movement processes is limited. Therefore, we demonstrate that dendrogeomorphological techniques, in combination with other parameters such as scar height on the trees, as well as a detailed geomorphological survey, allows for an understanding of the dynamics of debris flows, which, in the case of Mexico have not been previously evaluated using this approach.
Testing for Consumer Risk-Pooling in the Open Economy – further Results
Authors: Minford Patrick , Ou Zhirong , Zhu Zheyi
Published: August 2024

In this supplement to Minford et al. Int J Financ Econ 26(2):19932021 (2021), we revisit the ‘puzzle’ in open economy studies that evidence of international risk-sharing is hardly seen despite active cross-country financial markets. We reassess both risk-pooling via state-contingent bonds, and uncovered interest parity – both were believed to be different, and spuriously rejected, in previous work – in the context of a full DSGE model of the New Keynesian type. We prove that the two models are identical, both analytically and numerically. When tested as part of such a full DSGE model by indirect inference which circumvents the bias of single-equation tests, we find universal evidence of international risk-sharing.
Equivalent Circuit Model of Magnetoelectric Composite Nanoparticles
Authors: Ramezani Zeinab , Khizroev Sakhrat
Published: August 2024

This study presents an analysis of magnetoelectric nanoparticles (MENPs) through the development of equivalent circuits to predict the frequency-dependent magnetoelectric coefficient, with a focus on the widely utilized CoFe2O4@BaTiO3 core–shell configuration. This approach involves –derivation of phenomenological expressions that capture the dynamic behavior of MENPs under varying magnetic and electric fields. By integrating piezoelectric and magnetostrictive constitutive equations, along with consideration of dynamic effects and bio-load conjugation, a magneto-elasto-electric effect equivalent circuit has been constructed. This circuit model not only facilitates the investigation of longitudinal data in cube-shaped MENPs but also offers insights into fundamental biological processes. The versatility of this model is shown through translation to other core–shell nanoparticles, composite structures, and multiferroic nanostructures. This analysis provides quantitative predictions of the magnetoelectric coefficients, enhancing general understanding of MENP characteristics across a broad frequency range. Furthermore, the study highlights the framework for future refinement to incorporate intrinsic composition-specific resonances, such as ferromagnetic and ferroelectric resonances, to further significantly improve the nanoparticles’ performance. Overall, this work lays the groundwork for future technology to intelligently and wirelessly control biological processes using MENPs, thus paving a way for innovative biomedical applications. This quantitative approach may facilitate further interdisciplinary research and contribute to advancement of magnetoelectric materials and their applications.
Plasma/Ozone Induced PolyNaSS Graft-Polymerization onto PEEK Biomaterial for Bio-integrated Orthopedic Implants
Authors: Karthik Chandrima , Pillai Renjith Rajan , Moreno Gerardo Hernandez , Sikder Prabaha , Ambalavanan Namasivayam , Thomas Vinoy
Published: August 2024

Owing to its superior bulk mechanical properties, poly (ether ether ketone) (PEEK) has gained popularity over the past 15 years as a metal substitute in biomedical implants. Low surface energy is a fundamental issue with PEEK implants. This low surface energy caused by a moderately hydrophobic surface may be able to inhibit cellular adherence and result in the development of an inflammatory response, which may result in cell necrosis and apoptosis. In this work, plasma and ozone treatments have been utilized to surface activate PEEK and graft ionic bioactive polymer polyNaSS (poly (sodium styrene sulfonate)) successfully on the surface to promote cellular attachment and biomineralization. The main goal of our research has been to find a stable green process for surface modification of PEEK by plasma/ozone approaches to increase PolyNaSS grafting efficiency and biomineralization. To further the field of bioactive orthopedic and dental implant technology, this research attempts to address a significant constraint of PEEK implants while preserving their favorable mechanical properties.
PCSK9 and Coronary Artery Plaque—New Opportunity or Red Herring?
Authors: Barbieri Lucia , Tumminello Gabriele , Fichtner Isabella , Corsini Alberto , Santos Raul D. , Carugo Stefano , Ruscica Massimiliano
Published: August 2024

Purpose of Review

Although the clinical benefit of reducing low-density lipoprotein cholesterol (LDLc) in patients with coronary artery disease (CAD) is well-established, the impact on plaque composition and stability is less clear. Our narrative review aimed to assess the clinical effects of proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors on coronary plaque characteristics specifically focusing from atheroma progression to regression and stabilization.

Recent Findings

The combination of statin therapy and PCSK9 inhibitors (evolocumab and alirocumab) promotes plaque stability in patients following an acute coronary syndrome. The GLAGOV study highlighted the relationship between achieved LDLc levels and changes in percentage atheroma volume. Similarly, the PACMAN-AMI study concluded that the qualitative and quantitative changes in coronary plaque were associated with the levels of LDLc.

Assessing the severity of coronary artery stenosis and the extent of atherosclerotic burden by means of imaging techniques (e.g., IVUS, OCT and near-infrared spectroscopic) have significantly advanced our understanding of the benefits from promoting plaque regression and achieving to features of plaque stabilization through increasingly intensive lipid-lowering strategies.
No-touch technique for saphenous vein graft harvesting in coronary artery bypass surgery safely improves graft patency: a meta-analysis of randomized controlled trials
Authors: Soetisna Tri Wisesa , Thamrin Ahmad Muslim Hidayat , Ilham Mahardika Budjana Sutan , Darmawan Marko , Irfan Faris Maulana , Supit Vicky , Sugisman  , Hanafy Dudy Arman , Tjubandi Amin , Wartono Dicky Aligheri , Graha Wirya Ayu
Published: August 2024

Objective

The no-touch (NT) technique for saphenous vein graft (SVG) harvesting has been gaining popularity as several trials have shown its superiority in maintaining graft patency. However, this technique’s clinical outcome and safety are still disputed and the results vary widely. The aim of this meta-analysis of randomized controlled trials (RCTs) was to assess the effectiveness and safety of this method.

Methods

The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were conducted for this systematic review and meta-analysis. A comprehensive search of the literature was carried out with Embase, Scopus, and PubMed databases. The articles underwent extensive evaluation and analysis.

Results

Six RCTs comparing the NT and conventional (CON) techniques were included. Primary outcomes were measured using graft occlusion. Graft failure rates and clinical outcomes including major adverse cardiac and cerebrovascular events (MACCE), all-cause death, myocardial infarction, repeat revascularization, and leg wound complications were evaluated as secondary outcomes. The NT technique significantly decreased graft occlusion (risk ratio (RR) = 0.58; 95% confidence interval (CI) = 0.46 to 0.72; p < 0.001) and failure (RR = 0.65; 95% CI = 0.54 to 0.77; p < 0.001). Safety analysis also showed no significant risk difference for clinical outcomes, and although significantly higher, leg complications in the NT technique are minor and avoidable.

Conclusion

The NT technique increases long-term graft patency with no significant risk difference for clinical outcomes compared to the CON technique. However, the leg wound complications are significantly higher in the NT technique compared to the CON technique.

Graphical Abstract
A prognostic model constructed by ferroptosis-associated genes (FAGs) in papillary renal cell carcinoma (PRCC) and its association with tumor mutation burden (TMB) and immune infiltration
Authors: Chen Yong-Bo , Yang Xin , Lv Dong , Tang Liang-You , Liu Ying-Wen
Published: August 2024

Background

This study aimed to identify the prognostic-related differentially expressed ferroptosis-associated genes (DEFAGs) in papillary renal cell carcinoma (PRCC).

Methods

Data encompassing simple nucleotide variation, transcriptome profiles, and relevant clinical information of PRCC patients were sourced from The Cancer Genome Atlas (TCGA) database. The expression matrix of ferroptosis-associated genes (FAGs) was analyzed using the "limma" package in R to identify differentially expressed DEFAGs. Lasso regression analysis, along with univariate and multivariate Cox proportional hazards regressions, was employed to identify independent prognostic-related DEFAGs and formulate a nomogram. Additionally, we examined potential independent survival-related clinical risk factors and compared immune cell infiltration and tumor mutation burden (TMB) differences between high- and low-risk patient groups.

Results

A cohort of 321 patients were analyzed, revealing twelve FAGs significantly influencing the overall survival (OS) of PRCC patients. Among them, two mRNAs (GCLC, HSBP1) emerged as independent prognostic-related DEFAGs. Smoking status, tumor stage, and risk score were identified as independent clinical risk factors for PRCC. Furthermore, notable disparities in immune cell infiltration and function were observed between high- and low-risk groups. GCLC and HSBP1 were associated with various immune cells and functions, TMB, and immune evasion.

Conclusion

This finding revealed two independent prognostic-related DEFAGs in PRCC and established a robust prognostic model, offering potential therapeutic targets and promising insights for the management of this disease.
Quality of care assessment for non-small cell lung cancer patients: transforming routine care data into a continuous improvement system
Authors: Sánchez Juan C. , Nuñez-García Beatriz , Garitaonaindia Yago , Calvo Virginia , Blanco Mariola , Ramos Martín-Vegue Arturo , Royuela Ana , Manso Marta , Cantos Blanca , Méndez Miriam , Collazo-Lorduy Ana , Provencio Mariano
Published: August 2024

Purpose

The complexity of cancer care requires planning and analysis to achieve the highest level of quality. We aim to measure the quality of care provided to patients with non-small cell lung cancer (NSCLC) using the data contained in the hospital’s information systems, in order to establish a system of continuous quality improvement.

Methods/Patients

Retrospective observational cohort study conducted in a university hospital in Spain, consecutively including all patients with NSCLC treated between 2016 and 2020. A total of 34 quality indicators were selected based on a literature review and clinical practice guideline recommendations, covering care processes, timeliness, and outcomes. Applying data science methods, an analysis algorithm, based on clinical guideline recommendations, was set up to integrate activity and administrative data extracted from the Electronic Patient Record along with clinical data from a lung cancer registry.

Results

Through data generated in routine practice, it has been feasible to reconstruct the therapeutic trajectory and automatically calculate quality indicators using an algorithm based on clinical practice guidelines. Process indicators revealed high adherence to guideline recommendations, and outcome indicators showed favorable survival rates compared to previous data.

Conclusions

Our study proposes a methodology to take advantage of the data contained in hospital information sources, allowing feedback and repeated measurement over time, developing a tool to understand quality metrics in accordance with evidence-based recommendations, ultimately seeking a system of continuous improvement of the quality of health care.
Empowering or backfiring? The paradoxical effects of digital media skills on depression through (mis)information sharing on social media
Authors: Sun Mengru , Jia Wufan , Huang Guanxiong , Yu Wenting , Payton Brett
Published: August 2024

This study proposed and tested a novel theoretical framework of media empowerment regarding the relationship between digital media skills and mental health as well as the complex mechanism linking the two. This study utilized an online survey of a representative sample of Shanghai residents (N = 916) to examine the interconnections among digital media skills, (mis)information sharing, and mental health. The findings revealed that the empowerment mechanisms of digital media skills on depression were contradictory at the individual and community levels. For the two dimensions of digital media skills, information skills directly reduced levels of depression but indirectly aggravated depression by promoting misinformation sharing; in contrast, social skills alleviated depression by mitigating misinformation sharing. Furthermore, risk perception positively moderated the relationship between misinformation sharing and depression. This study contributes to the media empowerment literature by empirically demonstrating a linkage between developed digital media skills and media empowerment in the aspect of mental health in the digital age. This study also innovatively highlights specific psychosocial elements of the empowerment processes from a communication perspective.
Remote sensing insights into subsurface-surface relationships: Land Cover Analysis and Copper Deposits Exploration
Authors: Tshanga M Matthieu , Ncube Lindani , van Niekerk Elna
Published: August 2024

This review article examines the critical role of remote sensing techniques in analysing land cover and its implications for copper deposit exploration. The study aims to provide a comprehensive review of current research and technical advancements in using remote sensing to characterise land cover in copper-rich areas. It draws attention to the complex relationships that exist between subsurface copper mineralisation, surface vegetation, and soil types by combining case studies and modern literature. Integrating satellite imagery, geospatial data, and advanced analytical methods, this review demonstrates how remote sensing can effectively identify and map areas with high potential for copper deposits. Furthermore, it discusses the challenges and opportunities associated with remote sensing applications in geological studies and offers insights into future research directions to enhance mineral exploration and environmental management practices.
Luteinizing Hormone Receptor Mutation (LHRN316S) Causes Abnormal Follicular Development Revealed by Follicle Single-Cell Analysis and CRISPR/Cas9
Authors: Zhang Chen , Nie Yongqiang , Xu Bufang , Mu Chunlan , Tian Geng G. , Li Xiaoyong , Cheng Weiwei , Zhang Aijun , Li Dali , Wu Ji
Published: August 2024

Abnormal interaction between granulosa cells and oocytes causes disordered development of ovarian follicles. However, the interactions between oocytes and cumulus granulosa cells (CGs), oocytes and mural granulosa cells (MGs), and CGs and MGs remain to be fully explored. Using single-cell RNA-sequencing (scRNA-seq), we determined the transcriptional profiles of oocytes, CGs and MGs in antral follicles. Analysis of scRNA-seq data revealed that CGs may regulate follicular development through the BMP15-KITL-KIT-PI3K-ARF6 pathway with elevated expression of luteinizing hormone receptor (LHR). Because internalization of the LHR is regulated by Arf6, we constructed LHRN316S mice by CRISPR/Cas9 to further explore mechanisms of follicular development and novel treatment strategies for female infertility. Ovaries of LHRN316S mice exhibited reduced numbers of corpora lutea and ovulation. The LHRN316S mice had a reduced rate of oocyte maturation in vitro and decreased serum progesterone levels. Mating LHRN316S female mice with ICR wild type male mice revealed that the infertility rate of LHRN316S mice was 21.4% (3/14). Litter sizes from LHRN316S mice were smaller than those from control wild type female mice. The oocytes from LHRN316S mice had an increased rate of maturation in vitro after progesterone administration in vitro. Furthermore, progesterone treated LHRN316S mice produced offspring numbers per litter equivalent to WT mice. These findings provide key insights into cellular interactions in ovarian follicles and provide important clues for infertility treatment.

Graphical Abstract
Parameter identification by deep learning of a material model for granular media
Authors: Tanyu Derick Nganyu , Michel Isabel , Rademacher Andreas , Kuhnert Jörg , Maass Peter
Published: August 2024

Classical physical modeling with associated numerical simulation (model-based), and prognostic methods based on the analysis of large amounts of data (data-driven) are the two most common methods used for the mapping of complex physical processes. In recent years, the efficient combination of these approaches has become increasingly important. Continuum mechanics in the core consists of conservation equations that-in addition to the always-necessary specification of the process conditions-can be supplemented by phenomenological material models. The latter are an idealized image of the specific material behavior that can be determined experimentally, empirically, and based on a wealth of expert knowledge. The more complex the material, the more difficult the calibration is. This situation forms the starting point for this work’s hybrid data-driven and model-based approach for mapping a complex physical process in continuum mechanics. Specifically, we use data generated from a classical physical model by the MESHFREE software (MESHFREE Team in Fraunhofer ITWM & SCAI: MESHFREE. https://www.meshfree.eu, 2023) to train a Principal Component Analysis-based neural network (PCA-NN) for the task of parameter identification of the material model parameters. The obtained results highlight the potential of deep-learning-based hybrid models for determining parameters, which are the key to characterizing materials occurring naturally such as sand, soil, mud, or snow. The motivation for our research is the simulation of the interaction of vehicles with sand. However, the applicability of the presented methodology is not limited to this industrial use case. In geosciences, when predicting the runout zones of landslides or avalanches and evaluating corresponding protective measures, the parameterization of the respective material model is essential.
Quantizing Galilean spacetime: a reconstruction of Maxwell’s equations in empty space
Authors: Klein Ulf
Published: August 2024

As was recently shown, non-relativistic quantum theory can be derived by means of a projection method from a continuum of classical solutions for (massive) particles. In this paper, we show that Maxwell’s equations in empty space can be derived using the same method. In this case, the starting point is a continuum of solutions of equations of motion for massless particles describing the structure of Galilean space-time. As a result of the projection, the space-time structure itself is changed by the appearance of a new fundamental constant c with the dimension of a velocity. This maximum velocity c, derived here for massless particles, is analogous to the accuracy limit $$\hbar $$
ħ
derived earlier for massive particles. The projection method can thus be interpreted as a generalized quantization. We suspect that all fundamental fields can be traced back to continuous sets of particle trajectories, and that in this sense, the particle concept is more fundamental than the field concept.
A critical review of hydrochar based photocatalysts by hydrothermal carbonization: synthesis, mechanisms, and applications
Authors: Chen Zeliang , Guo Yanchuan , Luo Lei , Liu Zhengang , Miao Wei , Xia Yu
Published: August 2024

Hydrothermal carbonization (HTC) stands out as an eco-friendly, cost-effective method for generating renewable carbon-based materials from biomass. The HTC process yields products such as hydrochars and carbon dots (CDs), possessed of notable photocatalytic capabilities due to their unique physicochemical features. Additionally, pairing traditional photocatalysts with hydrochar derivatives elevates their performance, rendering them more effective. Recent times have witnessed a surge in interest in these hydrochar based photocatalysts (HC-photocatalysts). Their appeal stems from multiple attributes: impeccable performance, adaptability to visible light, and adjustable physicochemical properties. This review delves deep into the evolving landscape of these HC-photocatalysts, segmenting them into three distinct categories: hydrochars, hydrochar-based CDs (HC-CDs), and hydrochar-based composites (HC-composites). For each category, we dissect their synthesis routes, unravel the photocatalytic mechanisms, and explore various enhancement strategies. We further traverse their versatile applications, spanning environmental treatment, disinfection, energy conversion, and organic synthesis. In the end, we spotlight the prevailing challenges and uncharted territories in the domain of HC-photocatalysts. In essence, this review serves as a guide, furnishing a theoretical foundation and steering directions for future explorations and tangible implementations of HC-photocatalysts.

Graphical Abstract
Lobar collapse: what radiologists need to know
Authors: Mancò Giovanni , Caruso Valentina , Lezzi Giulio , Mastandrea Marco , Servietti Martina , Scutti Michela , Patea Rosa Lucia , Mereu Manuela , Caulo Massimo
Published: August 2024

Radiologists have to diagnose lobar collapse routinely, so they should be familiar with the direct and indirect signs of lobar atelectasis and with uncommon findings, for being able to make early diagnosis. Atelectasis can be caused by several mechanisms: by obstruction (due to neoplastic or non-neoplastic causes), by loss of negative pressure in the pleural space and/or by compression of lung parenchyma (e.g., pneumothorax, hydrothorax, and pleural effusion) or by an increase in alveolar surface tension (e.g., acute respiratory distress syndrome and neonatal respiratory distress syndrome). Collapses, moreover, can be observed in several ways. Lobar atelectasis occurs when entire pulmonary lobe is collapsed. Linear atelectasis (previously “plate like” or “band like”) is a local collapse with linear, plate-like or band-like shape which usually parallels the hemidiaphragms. Rounded atelectasis is a consequence of chronic or recurrent pleural effusion, which could be related to asbestos disease, chronic cardiac or renal failure, and thoracic malignancies. It occurs as a rounded mass abutting the pleura with adjacent pleural thickening. Collapsed lobes can assume quite limited forms and radiologists require familiarity with radiographic findings for helping clinical physician in the diagnostic process.
Mixing, Water Transformation, and Melting Close to a Tidewater Glacier
Authors: Inall Mark E. , Sundfjord Arild , Cottier Finlo , Korte Marie‐Louise , Slater Donald A. , Venables Emily J. , Coogan James
Published: August 2024

Marine‐terminating glacier fjords play a central role in the transport of oceanic heat toward ice sheets, regulating their melt. Mixing processes near glacial termini are key to this circulation but remain poorly understood. We present new summer measurements of circulation and mixing near a marine‐terminating glacier with active sub‐glacial discharge. 65% of the fjord's vertical overturning circulation is driven by the buoyant plume, however we newly report intense vertical and horizontal mixing in the plume's horizontal spreading phase, accounting for the remaining 35%. Buoyant plume theory supports 2%–5% of total glacial melt. Thus, most of the heat associated with vertical overturing short‐circuits the glacial front. We find however that turbulence in the horizontal spreading phase redistributes the short‐circuited heat back into the surface waters of the near‐glacial zone. Our findings highlight the need for further research on the complex mixing processes that occur near the glacier terminus.
Recent Upper Colorado River Streamflow Declines Driven by Loss of Spring Precipitation
Authors: Hogan Daniel , Lundquist Jessica D.
Published: August 2024

Colorado River streamflow has decreased 19% since 2000. Spring (March‐April‐May) weather strongly influences Upper Colorado River streamflow because it controls not only water input but also when snow melts and how much energy is available for evaporation when soils are wettest. Since 2000, spring precipitation decreased by 14% on average across 26 unregulated headwater basins, but this decrease did not fully account for the reduced streamflow. In drier springs, increases in energy from reduced cloud cover, and lowered surface albedo from earlier snow disappearance, coincided with potential evapotranspiration (PET) increases of up to 10%. Combining spring precipitation decreases with PET increases accounted for 67% of the variance in post‐2000 streamflow deficits. Streamflow deficits were most substantial in lower elevation basins (<2,950 m), where snowmelt occurred earliest, and precipitation declines were largest. Refining seasonal spring precipitation forecasts is imperative for future water availability predictions in this snow‐dominated water resource region.
Distinct protein patterns related to postnatal development in small for gestational age preterm infants
Authors: Smit Eva R. , Romijn Michelle , Langerhorst Pieter , van der Zwaan Carmen , van der Staaij Hilde , Rotteveel Joost , van Kaam Anton H. , Fustolo-Gunnink Suzanne F. , Hoogendijk Arie J. , Onland Wes , Finken Martijn J. J. , van den Biggelaar Maartje
Published: August 2024

Background

Preterm infants, especially those born small for gestational age (SGA), are at risk of short-term and long-term health complications. Characterization of changes in circulating proteins postnatally in preterm infants may provide valuable fundamental insights into this population. Here, we investigated postnatal developmental patterns in preterm infants and explored protein signatures that deviate between SGA infants and appropriate for gestational age (AGA) infants using a mass spectrometry (MS)-based proteomics workflow.

Methods

Longitudinal serum samples obtained at postnatal days 0, 3, 7, 14, and 28 from 67 preterm infants were analyzed using unbiased MS-based proteomics.

Results

314 out of 833 quantified serum proteins change postnatally, including previously described age-related changes in immunoglobulins, hemoglobin subunits, and new developmental patterns, e.g. apolipoproteins (APOA4) and terminal complement cascade (C9) proteins. Limited differences between SGA and AGA infants were found at birth while longitudinal monitoring revealed 69 deviating proteins, including insulin-sensitizing hormone adiponectin, platelet proteins, and 24 proteins with an annotated function in the immune response.

Conclusions

This study shows the potential of MS-based serum profiling in defining circulating protein trajectories in the preterm infant population and its ability to identify longitudinal alterations in protein levels associated with SGA.

Impact

Postnatal changes of circulating proteins in preterm infants have not fully been elucidated but may contribute to development of health complications.

Mass spectrometry-based analysis is an attractive approach to study circulating proteins in preterm infants with limited material.

Longitudinal plasma profiling reveals postnatal developmental-related patterns in preterm infants (314/833 proteins) including previously described changes, but also previously unreported proteins.

Longitudinal monitoring revealed an immune response signature between SGA and AGA infants.

This study highlights the importance of taking postnatal changes into account for translational studies in preterm infants.
Barriers and facilitators to accessing oral healthcare for older people in the UK: a scoping review
Authors: Beaven Anna , Marshman Zoe
Published: August 2024

Introduction Access to dental services is a growing problem for older people in the UK. The aim of this scoping review is to identify the barriers and facilitators influencing older people's ability to access oral healthcare in the UK based on the existing literature.

Methods The scoping review followed the framework proposed by Levac and colleagues (2010). Peer-reviewed literature was retrieved in April 2023 from Web of Science, Medline, PsycInfo and CINAHL for the period 1973-2023. After screening, data were extracted to identify barriers and facilitators mapped to individual, organisational and policy-level factors. The themes generated were used to identify gaps in the literature and policy recommendations.

Results Overall, 27 studies fulfilled the inclusion criteria. Most studies published were from England; there was a large representation of opinion pieces. The main barriers and facilitators related to cost of services, perceptions of dentistry, availability of services and both the dental and social care workforce.

Conclusion Multiple barriers exist surrounding access to dental care for older people. Various facilitators exist but not all are successful. More research needs to be carried out on older people's access to dental services in the community, particularly for the ‘oldest old' and minority groups.
Sumo-regulatory SENP2 controls the homeostatic squamous mitosis-differentiation checkpoint
Authors: Galán-Vidal Jesús , García-Gaipo Lorena , Molinuevo Rut , Dias Samantha , Tsoi Alex , Gómez-Román Javier , Elder James T. , Hochegger Helfrid , Gandarillas Alberto
Published: August 2024

Squamous or epidermoid cancer arises in stratified epithelia but also is frequent in the non-epidermoid epithelium of the lung by unclear mechanisms. A poorly studied mitotic checkpoint drives epithelial cells bearing irreparable genetic damage into epidermoid differentiation. We performed an RNA-sequencing gene search to target unknown regulators of this response and selected the SUMO regulatory protein SENP2. Alterations of SENP2 expression have been associated with some types of cancer. We found the protein to be strongly localised to mitotic spindles of freshly isolated human epidermal cells. Primary cells rapidly differentiated after silencing SENP2 with specific shRNAs. Loss of SENP2 produced in synchronised epithelial cells delays in mitotic entry and exit and defects in chromosomal alignment. The results altogether strongly argue for an essential role of SENP2 in the mitotic spindle and hence in controlling differentiation. In addition, the expression of SENP2 displayed an inverse correlation with the immuno-checkpoint biomarker PD-L1 in a pilot collection of aggressive lung carcinomas. Consistently, metastatic head and neck cancer cells that do not respond to the mitosis-differentiation checkpoint were resistant to depletion of SENP2. Our results identify SENP2 as a novel regulator of the epithelial mitosis-differentiation checkpoint and a potential biomarker in epithelial cancer.