bluuebunny/crossref_metadata_2025 huggingface dataset:
Shunt Migration in Children
Authors: Datta Debajyoti , Sekar Arunkumar , Guruprasad N , Bansal Sumit
Published: November 2022

Ventriculoperitoneal shunt insertion is one of the most common pediatric neurosurgical procedures performed. Shunt migration is one of the infrequent complications of shunt insertion and often requires a change of the shunt system. The objective of the study is to systematically review the sites of shunt migration and factors associated with mortality in children. Comprehensive search and review of the literature were done according to the PRISMA guidelines. Citations were selected using the following inclusion criteria: 1. Shunt migration in ventriculoperitoneal shunts was the primary inclusion criteria, 2. Age of the study participants <18 years, and 3. Patient-level data available in the study. Exclusion criteria were 1. Age >18 years, 2. Patient-level data not available, 3. Full text of the article not available, and 4. Article not in the English language. Sites of migration and risk factors for mortality were assessed. In total, 111 studies out of 161 studies were included in the final analysis. The scrotum was the most common site of shunt migration (30.67%), followed by anal migration, migration into the bowel, chest wall/thoracic migration, and intracranial/subgaleal migration. Univariate analysis showed the presence of infection and site of migration to be significantly associated with mortality. Multivariate analysis showed the presence of infection and age at presentation to be significant predictors of mortality. This study highlights that presence of infection is a significant predictor of mortality in cases of shunt migration. Infection should be managed expeditiously for optimum management of shunt migration.
Modified Eversion Carotid Endarterectomy
Authors: Zhang Xiao , Bai Xuesong , Feng Yao , Zhang Yinhang , Yang Renjie , Yang Yutong , Wang Tao , Xu Ran , Ma Yan , Jiao Liqun
Published: November 2022

Background:

Carotid endarterectomy (CEA) has been the standard therapy for carotid artery stenosis (CAS). Modified eversion carotid endarterectomy (mECEA) was recently introduced to treat CAS. However, the short-term safety and long-term efficacy of mECEA are still controversial among studies. This systematic review aims to summarize the current literatures about safety and efficacy of mECEA in treating CAS.

Methods:

A systematic review of mECEA was conducted in the main bibliographic databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Clinical studies on the safety and efficacy of mECEA in treating CAS with clinical results of transient ischemic attack (TIA), stroke, death, and restenosis were included.

Results:

The initial search and screening found 15 references from the main databases, and 7 studies were finally included after full-text article assessment, which consisted of 3 single-arm studies and 4 comparative studies. The risks of postoperative complications including TIA, stroke, myocardial infarction (MI), and death ranged from 1.1% to 2%, 0% to 2.5%, 0% to 4.4%, and 0% to 2.32%, respectively. The mECEA was significantly related to lower risk of carotid artery occlusion, incision numbness, and shorter lengths of stay in hospital and average scar when separately compared with conventional CEA (cCEA), CEA with patch closure (pCEA), and eversion CEA (eCEA).

Conclusions:

The mECEA is a promising surgical option for CAS with acceptable clinical outcomes. In order to prove its safety and efficacy, future practices need to be conducted by more medical workers in more large-scale trials.
Isolated Fetal Ventriculomegaly- Postnatal Outcomes and Proposed New Prognostication Classification
Authors: Tank Nilesh , Bawa Monika , Kanojia Ravi P , Singh Tulika , Samujh Ram
Published: November 2022

Background:

Outcome of Isolated ventriculomegaly diagnosed antenatally depends on size of ventricles and associated malformations. There is scarcity of literature on the guidelines for prognostication based on outcomes as per the ventricle size.

Aim:

The aim of this work was to study outcome of antenatally detected isolated ventriculomegaly in terms of medical termination, postnatal neuro-developmental milestones, and mortality; and also to propose a new prognostication classification.

Methods:

Prospective and retrospective observational study on antenatal mothers with isolated ventriculomegaly diagnosed in fetus. Outcomes in terms of termination of pregnancy, postnatal mortality, need of surgery, and morbidity were recorded. Patients were categorized into four groups: Group 1––ventricle size <10 mm, II––11–15 mm, III––16–20 mm, and IV > 20 mm and neuro-developmental milestones were co-related. Association with chromosomal anomalies, congenital heart disease, and maternal infection were also analyzed.

Results:

521 antenatal females were referred with fetal anomalies with 163 having CNS malformations. Isolated ventriculomegaly was seen in only 44. Patients of groups 1 and 2 had 100% normal neuro-developmental milestones without any intervention. Group 3 patients had normal neurodevelopmental milestones in 60% only while shunt surgery was required in 40% of patients. All patients of group 4 had poor outcome with only 50% survival. No association with chromosomal anomalies and heart disease was found.

Conclusions:

Prognosis of isolated ventriculomegaly depends upon size of ventricles and its progressive increase on serial ultrasounds. New proposed classification is simple and would be useful for the treating surgeons to explain the prognosis to parents so as to relieve them of anxiety.
Transrectal ultrasound examination of prostate cancer guided by fusion imaging of multiparametric MRI and TRUS: avoiding unnecessary mpMRI-guided targeted biopsy
Authors: Xu Guang , Li Jun-Heng , Xiang Li-Hua , Yang Bin , Chen Yun-Chao , Sun Yi-Kang , Zhao Bing-Hui , Wu Jian , Sun Li-Ping , Xu Hui-Xiong
Published: November 2022

The purpose of this study was to explore transrectal ultrasound (TRUS) findings of prostate cancer (PCa) guided by multiparametric magnetic resonance imaging (mpMRI) and to improve the Prostate Imaging Reporting and Data System (PI-RADS) system for avoiding unnecessary mpMRI-guided targeted biopsy (TB). From January 2018 to October 2019, fusion mpMRI and TRUS-guided biopsies were performed in 162 consecutive patients. The study included 188 suspicious lesions on mpMRI in 156 patients, all of whom underwent mpMRI-TRUS fusion imaging-guided TB and 12-core transperineal systematic biopsy (SB). Univariate analyses were performed to investigate the relationship between TRUS features and PCa. Then, logistic regression analysis with generalized estimating equations was performed to determine the independent predictors of PCa and obtain the fitted probability of PCa. The detection rates of PCa based on TB alone, SB alone, and combined SB and TB were 55.9% (105 of 188), 52.6% (82 of 156), and 62.8% (98 of 156), respectively. The significant predictors of PCa on TRUS were hypoechogenicity (odds ratio [OR]: 9.595, P = 0.002), taller-than-wide shape (OR: 3.539, P = 0.022), asymmetric vascular structures (OR: 3.728, P = 0.031), close proximity to capsule (OR: 3.473, P = 0.040), and irregular margins (OR: 3.843, P = 0.041). We propose subgrouping PI-RADS score 3 into categories 3a, 3b, 3c, and 3d based on different numbers of TRUS predictors, as the creation of PI-RADS 3a (no suspicious ultrasound features) could avoid 16.7% of mpMRI-guided TBs. Risk stratification of PCa with mpMRI-TRUS fusion imaging-directed ultrasound features could avoid unnecessary mpMRI-TBs.
F-18 Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in a Case of Subcutaneous T-cell Lymphoma Presenting as Breast Mass and Panniculitis-Like Features
Authors: Mishra Ayush , Saini Vivek Kumar , Jain Bela , Arya Amitabh , Ora Manish , Gambhir Sanjay
Published: November 2022

Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is an unusual subtype of cutaneous lymphoma and clinically appears as erythematous, subcutaneous infiltrates, and recurrent papulonodules. It is deﬁned as a rare cytotoxic a/b T-cell lymphoma characterized by primary involvement of subcutaneous tissue-mimicking panniculitis and a predominant CD3+/CD4/CD8+ phenotype in (2005) the World Health Organization-European Organization for Research and Treatment of Cancer classiﬁcation for cutaneous lymphomas. On metabolic imaging, these lesions are invariably fluorodeoxyglucose (FDG) avid. SPTCL which presents as a breast mass is a rare entity. Here, we present a case of SPTCL presents as FDG avid breast mass and subcutaneous nodules.
Technical competency required by postgraduate psychiatric nursing students
Authors: Sheikhbahaeddinzadeh Effat , Ashktorab Tahereh , Ebadi Abbas
Published: November 2022

BACKGROUND:

Technical skills result in the patient's safety. Psychiatric nurses need to learn and apply them to provide effective and secure cares. This study explains the technical competency required for postgraduate psychiatric nursing students.

MATERIALS AND METHODS:

This conventional qualitative content analysis study is part of a larger study on the clinical competency of postgraduate psychiatric nursing students performed in Iran in 2020. A qualitative study was conducted at universities holding master's degree courses in psychiatric nursing. Participants were instructors and postgraduate psychiatric nursing students, psychiatric nurses, psychologists, and psychiatrists selected by purposeful sampling method. Sampling continued until data saturation was achieved. Data were collected through a semi-structured individual interview and were analyzed by conventional qualitative content analysis.

RESULTS:

The “technical competency” has two subcategories of “specialized knowledge” (including general nursing knowledge, psychiatric nursing knowledge, and basic knowledge of psychology) and “application of knowledge in practice” (including clinical experience, skills of psychiatric nursing interventions, educational skills, and research and evidence-based practice skills).

CONCLUSION:

The psychiatric nursing student learns and operates knowledge of psychiatric nursing, psychology, education, and research, besides improving their knowledge of general nursing.
Identifying the factors affecting on interaction of faculty member
Authors: Mohammadimehr Mojgan , Haji Jamal
Published: November 2022

BACKGROUND:

The ability to interact and communicate effectively is one of the factors affecting the performance of faculty members, which is considered one of their basic competencies. The purpose of this study was to identify the factors affecting on interaction of faculty member with student and colleague, through the synthesis of literature.

MATERIALS AND METHODS:

The research method was qualitative with a meta-synthesis approach. Meta-synthesis was performed with Sandelowski and Barroso method. After the research of databases in the period 1995–2021, 259 studies were collected and finally 48 sources were selected and were included in the analysis phase. Coding method was used to analyze the data.

RESULTS:

Analyzing the findings of previous researchers and synthesizing the results, 155 codes, 18 subcategories, and 6 categories were identified and validated through kappa coefficient. The categories included “emotional-cognitive factor,” “sociocultural factor,” “communication factor,” “professional factor,” “educational factors,” and “management factor.”

CONCLUSION:

Based on the findings of this study and the importance of faculty members' interactions in medical universities, it is recommended that university officials and administrators use the results of this study to provide a suitable platform for creating and strengthening these interactions through holding workshops.
Family types and parenting styles for infants in Khon Kaen province
Authors: Photichai Piyanan , Luvira Varisara
Published: November 2022

BACKGROUND:

The care of infants during their first six months is a significant matter. As there have been shifts in social and economic conditions, families are diverging into several forms. This study aimed to explore parenting styles for infants and the relation between parenting styles for infants and family types.

MATERIAL AND METHOD:

This study was a cross-sectional study, focusing on the main caregivers of approximately six-month-old infants. The data was collected from February to July 2021. The research tool employed was an interview form. The collected data was then analyzed.

RESULTS:

Two hundred sixty-four families of primary caregivers were included in the study. The family type most frequently found was the skipped generation family, accounting for 119 families (45%). All family types mostly practiced the uninvolved parenting style as the parenting style for infants. Regarding response to infants, most families practiced the permissive parenting style. When investigating relations between parenting style for infants and family type, it was found that skipped generation family caregivers practiced a less authoritative parenting style than the nuclear family, including holding family activities with the infant (0.16, 95%CI: 0.05–0.47); when the infant raises their voice to communicate (0.32, 95%CI: 0.14–0.71); training the infant to roll over (0.21, 95%CI: 0.06–0.69); when the infant cries (0.16, 95%CI: 0.05–0.47); and when the infant does not respond (0.19, 95%, CI: 0.05–0.74)

CONCLUSION:

The most practiced parenting style for infants among all the three family types was the uninvolved parenting style. Regarding the response to infants, the permissive parenting style was mostly observed.
Crossroads experiences for promoting self-authorship of clinical medical students
Authors: Zarei Mehrnaz , Yazdani Shahram , Hosseini Fakhrolsadat , Sandars John
Published: November 2022

BACKGROUND:

The capacity of self-authoring one's own beliefs, identity, and relationships is core to many expected outcomes of future health-care professionals. Students' personal and professional development for self-authorship can be promoted by the variety of developmentally effective “crossroads” experiences that they encounter. Identifying the characteristics of the crossroads experiences in clinical rotations can provide a foundation for medical educators to provide an environment that can foster self-authorship.

MATERIALS AND METHODS:

A cross-sectional qualitative survey was conducted using a researcher developed semi-structured questionnaire which had three open questions and asked medical interns to describe their internship experiences that stimulated their thinking along the self-authorship dimensions of identity, relationships, and ways of knowledge acquisition. Data were analyzed using Braun and Clarkes' thematic analysis method.

RESULTS:

The survey was completed by 167 medical interns (response rate: 83%). The key features of significant crossroads experiences and their effects were created into six themes: Experiences by being respected and validated; experiences by involvement in patient management; experiences by participation in interactive learning environments; experiences by participation in authentic clinical work environments; experiences by the observation of professional behaviors; experiences through the uniqueness of different specialties.

CONCLUSION:

Authentic experiences of patient management in the real world of clinical settings with a high interactive environment have the potential to promote interns' self-authorship development. Educators can support learners by respecting and validating their capacities and by role modeling of professional behaviors.
Imperceptible learners
Authors: Farid Huma , Siddiqui Tania A. , Sukhia Rashna H. , Hasan Sana Jalil , Naveed Ayesha , Pasha Lubna
Published: November 2022

BACKGROUND:

“Should students keep their webcams on or off during synchronous online classes?” is an unanswered question with educators' opinions divided on this aspect. Along with educators' perspectives, it is also important to unfold students' perspectives on this question. The objectives of this study were to determine the routine and opinion of students' regarding webcam usage and identification of students' reasons for not using webcams during online learning.

MATERIALS AND METHODS:

A cross-sectional study was carried out at Margalla Institute of Health Sciences, Rawalpindi, Pakistan. Census was done for data collection by including all dental students (n = 180) enrolled at the institute attending synchronous online preclinical and clinical operative dentistry classes. Data collection was carried out using a self-administrated questionnaire. Descriptive analysis was used to describe survey item responses. Pair-wise differences between demographic categories (female vs. male, and preclinical vs. clinical) were analyzed using the Pearson Chi-Square test. Correlation of routine and opinion with students' reasons were done using Spearman correlation. Ordinal regression analysis was done to associate routine and opinion with reasons. The level of significance (P value) was set at 0.05.

RESULTS:

Out of 180 students, 141 submitted the survey form, with a response rate of 77.47%. The majority of the students (n = 117, 83%) used to keep their webcams off during online classes and were (n = 69, 48.9%) of the opinion that webcams should be kept off during online classes. The most common reasons for keeping the webcam off during online classes were “comfort” (n = 87, 61.7%) and “distractions” (n = 84, 59.6%). A statistically significant association of gender was obtained, with females more likely than males due to distraction, self-consciousness, and appearance (P = 0.000, 0.003, and 0.016, respectively). The odds of gender highly influenced routine use of cameras, and this was statistically significant (OR: 3.478, P = 0.011). Students tended to keep their webcam off when they were inattentative during online classes (OR; 3.743, P < 0.001).

CONCLUSION:

The majority of the students did not agree to keep the webcam on during online synchronous learning. The main reasons for students’ reluctance to keep the webcam on were self-consciousness, surrounding consciousness, distractions, and technological issues. Students can be encouraged to turn the webcam on by framing strategies according to students’ concerns.
Using student-designed cases to foster creative and critical thinking skills in biochemistry
Authors: Vani Axita C. , Stephen Sherin , Anjana V , Sreekala P. L , Eranholi Prabeesh , Rema A. K
Published: November 2022

BACKGROUND:

In this novel intervention, we have tried to incorporate case-based learning with creative and critical thinking. Creative thinking indulges students to generate and apply new concepts in specific situations, seeing current situations in a new light, identifying alternative theories, and exploring new links that help generate a positive outcome. This may involve combining various hypotheses to form something original, sifting and refining ideas to discover possibilities, constructing new theories, and acting on intuition.

MATERIALS AND METHODS:

This is a quasi-experimental study on educational intervention. First Bachelor of Medicine and Bachelor of Surgery (MBBS) students (N = 80) in their First MBBS students were randomly divided into control (n = 40) and study (n = 40) groups after they had undergone case-based learning in their first semester. The study group was asked to prepare three cases each on type II diabetes mellitus (DM), Fe deficiency anemia, and obstructive jaundice by discussion. Each case was prepared with a) an introduction consisting of presenting complaints, b) body comprising laboratory findings, and c) five questions related to the case. The cases were reviewed by a facilitator and presented to the other groups for discussion. Pretest and posttest questionnaires were collected and analyzed.

RESULTS:

Based on the pretest scores, students were grouped as low, average, and high performers. Wilcoxon signed rank test was performed, which revealed significant improvement in the posttest scores of all students in the study group.

CONCLUSION:

By designing new case histories themselves, students were able to understand the biochemical concepts of common diseases and apply these concepts in causation of diseases. Thus, case-based learning in this setting helped to foster creative and critical thinking skills of first MBBS students.
Resilience related to novel coronavirus among doctors and undergraduate medical students-A study from India
Authors: Verma Anant Kumar , Ayub Arshad , Singh Ganesh Prasad , Kumar Amardeep
Published: November 2022

BACKGROUND:

There are no studies pertaining to resilience related to novel coronavirus focusing primarily on doctors and undergraduate medical students in India. The objectives of this survey were to assess the resilience and its various domains that are needed for dealing with novel coronavirus among doctors, interns, and undergraduate students and to see its correlation with various sociodemographic factors.

MATERIALS AND METHOD:

An online cross-sectional survey was done among doctors and undergraduate medical students during the first COVID-19 wave from May 19, 2020 to June 8, 2020. A total of 434 responses were recorded during the study period. All the recorded full responses were considered for data analysis. Snowball sampling was used for this study. Resilience was assessed using three items, which were taken from the Brief Resilience Scale (BRS).

RESULT:

Out of 434 responses, 51.7% (224/433) of the respondents were non-resilient. The presence of the elderly at home was significantly associated with poor resilience (P = 0.02). Resilience was not significantly associated with other socio-demographic factors. Younger respondents (P = 0.019) and females (P =0.0004) were of the opinion that they recovered late from stressful events. Elderly respondents (P = 0.003) and those with chronic illness (P = 0.008) reported that it is hard for them to snap back if something bad happens (P = 0.003).

CONCLUSIONS:

More than half of the doctors and undergraduate medical students were found to be non-resilient, underscoring the urgent need to take steps to improve the resilience of this group of frontline workers.
Study of suicidal thoughts and intentions with regard to job stress among female medical students living in dormitory with a mental health promotion approach
Authors: Sahlabadi Ali Salehi , Balochkhaneh Faezeh Abbasi , Gousheh Seyed Nouredin Hosseini , Vatani Javad , Eshaghzadeh Maliheh , Bidel Hamideh
Published: November 2022

BACKGROUND:

Medical students are exposed to stresses which have irreversible consequences, such as suicidal ideation. The present study aimed to investigate the level of occupational stress in medical students and its relationship with the prevalence of suicidal ideation and attention among them and then provide mental health promotion approaches.

MATERIALS AND METHODS:

This cross-sectional descriptive study was performed on 325 undergraduate medical students residing at the dormitory of Shahid Beheshti University of Medical Sciences. The sample size was determined by the census method. Osipow and Suicide Behaviors Questionnaires were used to measure job stress and suicidal ideation, respectively. The condition of entry into the study was living in the dormitory and spent at least one semester. Linear regression and logistic regression were used to examine the relationship between variables.

RESULTS:

The mean score of occupational stress among students with a mean age of 21 (±2.18) years was 158.84 (±27.07) and 60% (n = 180) of students had high levels of stress. There was a significant relationship between age and educational level with stress level and suicidal ideation (P < 0.05). They had the highest effect on stress (P = 0.031) and suicidal ideation (P = 0.001), respectively, among students. High level of stress was 11.829 times more likely to have suicidal thoughts than low-stress level (P < 0.001).

CONCLUSIONS:

Stress and suicidal ideation are much higher in students of lower semesters and lower ages than students with higher semesters. Students should learn how and with what approach to control and manage exposure to stressors. Measures such as holding stress management training courses as well as managing stressful situations are among the effective measures in improving mental health and reducing stress levels and its effects.
Disseminated Cytomegalovirus Infection in a Child with Langerhans Cell Histiocytosis
Authors: Iswarya Polina Siri , Jayaraman Dhaarani , Rajan X. Joshua , Prabaharan Krithika
Published: November 2022

Cytomegalovirus (CMV) reactivation is well known in post-transplant immunocompromised children. However, the incidence in non-transplant patients is significantly less, and only scarce case reports are available in the literature regarding CMV disease in children with solid tumors. We present a 3-year-old male child with multisystem refractory Langerhans cell histiocytosis, who had very high CMV viremia and disseminated CMV infection with secondary hemophagocytic lymphohistiocytosis and was successfully treated without organ damage and sequelae. Although routine screening is not recommended, CMV viremia/disease needs to be considered in non-transplant immunocompromised children with multisystem involvement with unexplained cytopenia.
Delftia acidovorans: An Unusual Pathogen from an Adenocarcinoma Lung Patient with Pleural Effusion
Authors: Lall Sujata , Bhat Vivek , Biswas Sanjay , Joshi Amit , Janu Amit
Published: November 2022

Delftia acidovorans (D. acidovorans) is an aerobic, nonfermentative Gram-negative bacillus infrequently isolated from clinical specimens. The pathogenicity and clinical significance of the organism has not been ascertained due to uncommon clinical isolation and suspected low virulence. The organism has been reported to be inherently resistant to aminoglycoside group of drugs which remain as a widely used first-line drug of choice for febrile neutropenic patients. Hereby, we report a case of D. acidovorans-associated pleural effusion in a patient of metastatic adenocarcinoma diagnosed and treated timely and successfully with appropriate antibiotics.
An uncommon case of primary synovial sarcoma of the lung with a rare intraoperative finding
Authors: Venkatappa Rajashekara Reddy Hosahalli , Reddy Chemuru Munisekhar
Published: November 2022

We report a case of a 32-year-old male who was evaluated for right chest pain and cough with streaky hemoptysis. Chest X-ray and contrast-enhanced computerized tomography scan of the chest showed a large (20x16×16 cm), heterogeneously enhancing mass arising from the right lower lobe. Ultrasound-guided Tru-cut biopsy revealed spindle cell sarcoma. In immunohistochemistry, tumor cells expressed epithelial membrane antigen, CD99, and bcl-2. The final diagnosis of primary pulmonary synovial sarcoma was confirmed after positron emission tomography-computed tomography revealed that the lesion was confined to the right lung. The patient was managed by multimodal treatment. The patient underwent right anterolateral thoracotomy and lower lobectomy with staged systematic mediastinal lymphadenectomy. Intra-operatively, he was given 2 units of packed red blood cells (RBCs). The patient developed dark-colored urine near the end of the transfusion of the second unit of packed RBCs, but without any hemodynamic instability. All the tests for possible blood transfusion reactions were negative; thus, we concluded that this event was probably secondary to tumor lysis due to the handling of the large primary lesions during surgery.
Vai trò của trách nhiệm xã hội kỹ thuật số đến truyền miệng điện tử và lòng trung thành thương hiệu thông qua sự gắn kết với thương hiệu trên mạng xã hội
Authors: Hoàng Đinh Văn
Published: November 2022

Tóm Tắt

Nghiên cứu này nhằm mục đích xem xét ảnh hưởng của nhận thức khách hàng về trách nhiệm xã hội trong môi trường kỹ thuật số tác động đến sự gắn kết với thương hiệu trên mạng xã hội Facebook dẫn đến hành vi truyền miệng điện tử về thương hiệu và lòng trung thành với thương hiệu. Nghiên cứu được thực hiện bằng cách khảo sát với người sử dụng mạng xã hội Facebook có tham gia tương tác trực tuyến các chương trình mang tính trách nhiệm xã hội của doanh nghiệp tại thành phố Hồ Chí Minh trên mạng xã hội Facebook. Dữ liệu sau khi sàng lọc gồm 309 mẫu được dùng phân tích PLS-SEM. Kết quả phân tích cho thấy nhận thức về trách nhiệm xã hội kỹ thuật số có ảnh hưởng tích cực đáng kể đến sự gắn kết sự gắn kết với thương hiệu trên mạng xã hội Facebook, truyền miệng điện tử về thương hiệu với các hoạt động trách nhiệm xã hội kỹ thuật số trên mạng xã hội Facebook và lòng trung thành với thương hiệu. Ngoài ra nghiên cứu cũng xem xét sự gắn kết với thương hiệu trên mạng xã hội Facebook là khái niệm bậc cao trên 5 khía cạnh (sự nhận diện, sự nhiệt tình, sự chú ý, sự hấp thụ, sự tương tác) để làm rõ vai trò của sự gắn kết với thương hiệu trên mạng xã hội Facebook đối với truyền miệng điện tử và lòng trung thành.

ABSTRACT

This Research is aimed to examine the influence of customer perception of social responsibility in the digital environment with the brand on Facebook, the electronic word of mouth of the brand, and brand loyalty. The study was carried out by surveying Facebook users who participate in online interactions with corporate social responsibility programs in Ho Chi Minh City. Data after screening includes 309 samples using PLS-SEM parsing. Analytical results show that digital social responsibility awareness has a positive effect on engagement with the brand on Facebook, electronic word of mouth, and brand loyalty. In addition, the study also considers customer engagement with the brand on Facebook as a quadratic concept on 5 dimensions (awareness, enthusiasm, attention, absorption, and interaction) to raise stated turn on the role of customer engagement with the brand on Facebook for electronic word of mouth and loyalty
Régimen jurídico del cronista oficial de municipios, provincias y Comunidades Autónomas
Authors: Osuna Luque Rafael
Published: November 2022

Esta obra hace dos aportaciones iniciales y plausibles que no deben pasar inadvertidas. Por un lado, presenta una visión de conjunto de la figura del cronista oficial que facilita la compresión de su relevancia y la diversidad de sus funciones y, por otro, aúna criterios y establece normas jurídicas en un panorama que hasta ahora era tremendamente dispar y desordenado.
“We Live on an Island:” Perspectives on Rural Family Caregiving for Adults with Alzheimer’s Disease and Related Dementias in the United States
Authors: Williamson Heather , Begay Andria , Dunn Dorothy , Bacon Rachel , Remiker Mark , Garcia Yolanda , McCarthy Michael , Baldwin Julie
Published: November 2022

As the United States’ aging population grows, there will be increased prevalence of individuals living with Alzheimer’s Disease and related dementias (ADRD), who largely rely on the support of their family caregivers. Family caregivers residing in rural areas face additional challenges with managing caregiving responsibilities and navigating support services. The purpose of this multilevel phenomenological qualitative study was to explore the assets, unique needs, and resources of rural-residing ADRD caregivers from the caregiver, provider, and policy influencers’ perspectives. The study took place between 2019 through 2021 in northern Arizona, a largely rural and geographically vast area home to caregivers from diverse backgrounds. Twenty-seven caregivers to a loved one with ADRD participated in focus groups. Twelve health and social services providers and twelve policy influencers, those involved in leadership positions for aging programs or advocacy groups, completed individual interviews. Caregivers demonstrate many assets which contribute to their ability to manage and cope with their caregiving role. However, caregivers face a series of issues related to their caregiving role and need early and ongoing education regarding ADRD. There is a lack of resources available in rural areas, in particular providers, making it challenging to obtain needed resources necessary to support their loved one with ADRD. Furthermore, there is a need for more providers trained in working with aging adults and those experiencing ADRD, and a need for more culturally relevant resources.
Blood Sampling Techniques and Preparing for Analysis in Rainbow Trout (Oncorhynchus mykiss)
Authors: DURAN Utku , ÇENESİZ Sena , ŞAHİN Büşra
Published: November 2022

In aquaculture, biochemical and hematological analyzes are frequently performed for scientific research, health screening and diagnosis of diseases. Biochemical and hematological parameters in fish as in other vertebrates varies nutrition, water quality, pathogens and various environmental factors that can create stress. Caudal vascular blood collection is a non-invasive method that is widely used to investigate fish health, biochemistry, and physiology. As a result of this method being performed under the influence of a properly selected anesthetic agent, animal welfare is affected the least, thus preventing a serious change in biochemical parameters with minimum stress. In this review, sampling collection suitable for the analysis to be performed and choosing the right anesthetic agent are presented.
Systematic Analysis of CMR Segmentation Using Deep Learning
Authors: PARIKH YOGITA , Dr. Hasmukh Koringa
Published: November 2022

This review provides an overview of cardiac segmentation by using Deep learning for MR images. Cardiac MR is widely used due to its unique capability as non invasive imaging. CMR images are used to derive cardiac indices to diagnose various cardiac diseases by segmentation of heart chambers. There are number of challenges in automatic cardiac MR segmentation due to characteristics of MR images because of continuous movement of heart. Now days, deep learning become widely used technique to segment heart chambers for efficient and accurate results. In this review, we provide overview of publically available CMRI datasets, descriptions of currently available methods to segment Left ventricle, Right ventricle, and Myocardium. After reviewing various techniques, we describe limitations and possible solutions. We conclude deep learning based segmentation issues in the currentapproaches.
Association of Hepcidin levels in Type 2 Diabetes Mellitus treated with metformin or combined anti-diabetic agents in Pakistani population
Authors: Tabinda Najeeb  , Mohammad Saleh Soomro (late)  , Asher Fawwad  , Nazish Waris  , Ruqaya Nangrejo  , Iftikhar Ahmed Siddiqui  , Qamar Aziz  , Abdul Basit  , Admin
Published: November 2022

Objective: To evaluate the impact of hepcidin and ferritin in pathogenesis and prognosis of type 2 diabetes mellitus subjects taking only metformin or combined anti-glycaemic agents.
Methods: The observational case-control study was conducted at the Department of Physiology, Baqai Medical University, Karachi, from August 2019 to October 2020, and comprised subjects from both genders who categorised into equal groups as non-diabetic controls, newly-diagnosed type 2 diabetes mellitus patients without any treatment, type 2 diabetes mellitus patients with exposure to metformin only, type 2 diabetes mellitus patients taking oral hypoglycaemic agents along with metformin, type 2 diabetes mellitus patients taking only insulin, and type 2 diabetes mellitus patients taking insulin and oral hypoglycaemic agents. Fasting plasma glucose was determined using glucose oxidase-peroxidase method, glycated haemoglobin by high performance liquid chromatography, high-density lipoprotein and low-density lipoprotein by direct methods, cholesterol by cholesterol oxidase phenol 4-amino antipyrine peroxidase and triglycerides by glycerol phosphate oxidase-phenol 4-amino antipyrine peroxidase method. Serum levels of ferritin, insulin and hepcidin were evaluated using Enzyme-linked immunosorbent assay. Insulin resistance was assessed using homeostasis model assessment for insulin resistance. Data was analysed using SPSS 21.
Results: Of the 300 subjects, there were 50(16.66%) in each of the 6 groups. Overall, there were 144(48%) males and 155(51.66%) females. The mean age was significantly lower in the control group 34.72±7.87 compared to all the diabetic groups (p<0.05), and the same was the case with respect to all the parameters (p<0.05) except high-density lipoprotein (p>0.05). Besides, hepcidin level was significantly higher in the control group (p<0.05). Ferritin levels were significantly increased in newly-diagnosed T2DM subjects compared to the controls (p<0.05) while all other groups showed decreased ferritin levels (p<0.05). Hepcidin gave inverse correlation with glycated haemoglobin only in diabetics taking only metformin (r = -0.27, p=0.05).
Conclusion: Anti-diabetes drugs not only addressed type 2 diabetes mellitus, but also reduced levels of ferritin and hepcidin that are found to play a role in diabetes development.
Key Words: Ferritin, Hepcidin, Insulin, Oral hypoglycaemic agents, T2DM.
Medium Aplikasi Atas Talian dalam Pembelajaran Sejarah di Luar Waktu Persekolahan
Authors: Tajudin Norrolnadia , Hashim Shahabudin
Published: November 2022

Perkembangan teknologi pada masa kini tidak dapat dijangkal oleh manusia pada kini terutama dalam perkembangan dalam teknologi telekomunikasi. Perkembangan telekomunikasi ini bukan setakat memberikan kemudahan dalam perhubungan jarak jauh malah dalam dunia pendidikan seperti kelangsungan pembelajaran di luar waktu persekolahan. Kajian ini bertujuan untuk melihat medium aplikasi atas talian yang sering digunakan oleh guru sejarah dan sejauh manakah keberkesanan medium ini mempengaruhi dalam pembelajaran sejarah diluar waktu persekolahan. Kajian ini menggunakan kaedah kualitatif yang melibatkan empat orang guru sejarah sekolah menengah. Hasil kajian ini mendapati bahawa aplikasi Telegram dan WhatsApp merupakan medium yang sering digunakan oleh guru sejarah dalam menyampaikan sebarang bentuk maklumat pembelajaran kepada pelajar. Persepsi guru sejarah menunjukkan positif terhadap penggunaan medium aplikasi atas talian diluar waktu persekolahan. Oleh itu, guru sejarah pada masa kini perlu lebih kreatif dan mempunyai inisiatif dalam mempertingkatkan minat pelajar terhadap mata pelajaran sejarah.
Persepsi Pelajar Pintar dan Berbakat Terhadap Penggunaan Filem dalam Pembelajaran dan Pemudahcaraan (PdPc) Subjek Sejarah
Authors: Maarof Nurul Hafizah , Joli Nurul Suzaina , Apfandi Norfiza , Md Zain Nor Syamilah , Yusof Rorlinda
Published: November 2022

Penggunaan filem dalam pembelajaran dan pemudahcaraan (PdPc) merupakan salah satu alternatif yang digunakan oleh para pendidik bagi menarik minat pelajar untuk mempelajari subjek Sejarah. Ia merangkumi elemen penting seperti semangat patriotisme serta nilai-nilai murni yang dapat disampaikan kepada pelajar dengan kaedah santai dan menyeronokkan berbanding kaedah konservatif. Dalam kajian ini, terdapat tiga persoalan utama telah dikenal pasti antaranya tahap persepsi pelajar pintar dan berbakat (PB) terhadap keberkesanan filem dalam PdPc, perbezaan min bagi konstruk keberkesanan filem dalam PdPc, dan tahap kefahaman pelajar PB terhadap keberkesanan filem dalam PdPc subjek Sejarah. Oleh yang demikian, bagi menilai persepsi pelajar terhadap penggunaan filem dalam PdPc bagi subjek Sejarah, seramai 84 orang pelajar PB dari Kolej GENIUS@Pintar Negara, UKM telah dipilih secara bertujuan bagi memenuhi keperluan kajian ini. Kesemua responden terdiri daripada pelajar Tahap 1 yang berumur lingkungan 15 hingga 16 tahun. Instrumen skala likert digunakan bagi menilai item-item yang dijadikan kayu ukur terhadap persepsi pelajar PB antaranya konstruk sikap, motivasi, kemudahan akses dan kemahiran pemikiran Sejarah (KPS). Perisian SPSS V 2.0 digunakan bagi menganalisis data-data tersebut. Hasil dapatan kajian menunjukkan bahawa penggunaan filem dalam PdPc telah memberikan kesan yang memberangsangkan kepada pelajar PB untuk mempelajari subjek Sejarah. Selain itu, inisiatif ini turut memberi galakan kepada pengkarya filem untuk menghasilkan lebih banyak lagi filem yang bergenre Sejarah kerana ia secara langsung dapat menyumbang dalam PdPc yang lebih kreatif. Kajian lanjutan berkaitan filem dalam PdPc subjek Sejarah juga harus dijalankan agar ianya dapat dimanfaatkan oleh para guru, pengkaji serta pengkarya seni tanah air pada masa akan datang.
Impacts of Climate Change on Tourism in Malaysia: Assessing the Community Perspectives
Authors: Mohd Shariff Nurhazani
Published: November 2022

Climate change is a critical issue today which significantly affected the ecosystem of the community. The government of Malaysia has constructed and implemented numerous policy and plan in order to curb the climate change but it is sad to see that this country is still at the moderate phase of overcoming the issue. Climate change consequences on tourism are crucial because it increases the danger of species extinction, decreases freshwater, increases wildfire accidents, heat waves, and illnesses, all of which cause visitors to avoid certain places. Being aware of climate change consequently help the communities to prepare for its effects. As a result, the community is also becoming more educated and able to develop proactive and reactive measures to combat climate change and reducing their social vulnerability. Hence, this study surveyed the impacts of climate change on tourism in Malaysia by assessing the perspectives of the community. The researcher had distributed questionnaire survey to 400 respondents representing the communities in various destinations in Malaysia which are directly and indirectly affected by climate change. The findings indicated that three domains derived and were named as socio-economic impacts, physical impacts and environmental impacts. This study significantly provides the tourism stakeholders in Malaysia to understand in-depth the perceptions of the community towards the impacts of climate change on tourism and taking further actions to overcome the issues.
Where music meets medicine:
Authors: Debus Eike Sebastian , Van Moreau Dorothee , Van Moreau Dorothee , Holzwarth Karin , Baaß David , Spintge Ralph
Published: November 2022

The first Science and Sounds conference in Germany took place in early September 2022. Attendees were provided with an overview of standards and significant results of scientific research on the use of music as therapeutic intervention in medical settings. An international faculty of experts from USA, Finland, and Europe presented a scientific program ranging from definitions in MusicMedicine and Music Therapy, latest results from brain research about important impacts of musical stimuli on neuronal networks -explaining therapeutic results as well as directions for occupational care for musicians. General aspects and global developments in furthering implementation of interdisciplinary approaches in research and application including enhancement of professional environment in health care institutions were discussed and practically demonstrated during clinical excursions to UKE facilities. This article will provide an overview of the conference and will highlight our opening of the new Centre.
Structure-Based Design and Molecular Simulations of Some Quercetin-Based Drugs as Repurposable Inhibitors of SARS-CoV-2 Main Protease
Authors: Ayipo Yusuf Oloruntoyin , Alananzeh Waleed A , Abdulsalam Zuliah Abiola , Badeggi Umar Muhammad , Jimoh Akeem Adebayo , Osunniran Wahab Adesina , Mordi Mohd Nizam
Published: November 2022

In this study, virtual screening and molecular dynamics (MD) protocols were applied to screen 2826 FDA-approved natural product drugs from the Selleckchem.com library for prospective inhibitors of the SARS-CoV-2 main protease. From the virtual screening through HTVS, SP and XP docking analysis, hyperoside, rutin hydrate, rutoside and quercitrin displayed a stronger binding affinity with respective XP docking scores of –11.389, –11.340, –11.087 and –10.232 kcal/mol than co-crystallized N-[2-(5-fluoro-1H-indol-3-yl)ethyl]acetamide  (HWH) and positive inhibitors, lopinavir and ritonavir which scored –5.493, –6.463 and –6.221 kcal/mol respectively. Selectively, the binding free energy, MMGB(SA) of hyperoside and rutin hydrate was observed as –21.55 and –25.82 kcal/mol respectively compared to lopinavir and ritonavir with –17.66 and –5.28 kcal/mol respectively. Consistently, the selected drugs displayed good thermodynamics conformational stability, thus, recommended as promising repurposable inhibitors of the SARS-CoV-2 main protease amenable for further studies.
HIGHLIGHTS

Main protease of the SARS-CoV-2 represents a plausible target for mitigating viral replication
Natural repurposable drugs are safer and cheaper for combating COVID-19
Hyperoside, rutin hydrate and quercitrin displayed strong binding and stability with the viral main protease
They are recommended as repurposable inhibitors of SARS-CoV-2 main protease for further studies

GRAPHICAL ABSTRACT
EFL Student's Perception On Whatsapp Use For Learning English At Junior High School
Authors: Endistira Leli , Prasiska Puspita Tohamba Citra , Faridawati Faridawati
Published: November 2022

Penelitian ini bertujuan untuk mengetahui persepsi siswa dalam menggunakan WhatsApp sebagai media pembelajaran bahasa Inggris pada siswa kelas VII-2 di SMPN 1 Wundulako Kabupaten Kolaka Provinsi Sulawesi Tenggara.  Penelitian ini dilaksanakan di SMP Negeri 1 Wundulako pada bulan Oktober 2021. Untuk menjawab pertanyaan penelitian digunakan desain penelitian kualitatif dengan subjek penelitian adalah siswa kelas VII-2.  Data diperoleh dengan melakukan wawancara yang di dasarkan oleh 5 aspek yang di adaptasi oleh teori Rubin & Chisnell (2008), yaitu learnability, efficiency, memorability, error dan satisfaction. Hasil penelitian menunjukkan kecenderungan ke persepsi positif di aspek learnability, efficiency, memorability dan satisfaction. Sebagian besar siswa EFL merasa senang karena belajar bahasa Inggris melalui WhatsApp mudah karena dapat belajar dimana saja dan kapan saja. Melalui fitur-fiturnya, WhatsApp memudahkan komunikasi dan meningkatkan interaksi dengan guru atau teman sekelas, meningkatkan sikap positif siswa, meningkatkan hasil belajar siswa di kelas, siswa menjadi lebih aktif, lebih fasih berbahasa Inggris dan dapat mengetahui kosakata bahasa Inggris baru.
Faricimab (Vabysmo)
Authors: CADTH
Published: November 2022

CADTH recommends that Vabysmo be reimbursed by public drug plans for the treatment of diabetic macular edema (DME) if certain conditions are met.

Vabysmo should be covered to treat patients with DME provided that it is covered for a similar patient population and in a similar way to other anti–vascular endothelial growth factor (VEGF) drugs currently reimbursed by public drug plans for the treatment of adult patients with DME.

Vabysmo should only be reimbursed if prescribed by an ophthalmologist with experience managing DME and if the cost of Vabysmo is not more than the least costly anti-VEGF drug covered by the public drug plans for the treatment of DME.
A RESPONSABILIDADE PENAL DO MÉDICO NOS CASOS DE VIOLÊNCIA OBSTÉTRICA NO PARTO
Authors: Lemos Gabriel Fernandes , Botelho Daniela Garcia
Published: November 2022

A violência obstétrica é aquela que ocorre no período da gestação, no parto, no nascimento e, ainda, após o parto. Sua prática se dá por intervenções lesivas à integridade física, psicológica e/ou sexual. Embora não se tenha um tipo penal específico para punir os agentes imputadores de violência obstétrica, o Código Penal dispõe de vários dispositivos no que se refere à prática em comento.  O presente artigo visa analisar a responsabilidade penal do médico nos casos de violência obstétrica no parto, considerando assim a relevância em conhecer e discutir o dever destes para com a parturiente no momento do parto. Objetiva-se, assim, conhecer os direitos das partuirentes à luz da Constituição Federal e outras legislações que abordam a temática, assim como identificar a situação do médico como garantidor e conhecer as penas aplicáveis ao médico nos casos de violênia obstétrica. A metodologia utilizada neste estudo é a revisão de literatura, realizada por meio de busca em artigos científicos, livros teóricos, periódicos, assim como em banco de dados em sites que abordam o assunto em pauta.