bluuebunny/crossref_metadata_2025 huggingface dataset:
Advanced glycation end products promote polycystic ovary syndrome by regulating AMH via PI3K/Akt/SF1 signaling pathway
Authors: Zhu Jingling , Liu Minqi , Cheng Di , Zeng Zhaoming , Xie Yuanjie , Cen Liying , Huang Yuanjiao , Tan Yi , Mo Zhongcheng
Published: February 2024

Background：Advanced glycation end products (AGEs) are involved in the pathogenesis of polycystic ovary syndrome (PCOS)and high concentrations of anti-Müllerian hormone (AMH) are considered one of the primary causes of anovulation in women with PCOS. However, the specific mechanism of action remains unclear.
Method and Results: Ovarian granulosa cells (KGN cells) were treated with AGEs at different concentrations and times. The results showed that pretreatment with AGEs concentration-dependent and time-dependent affected the expression of AMH and SF1. PCNA expression was suppressed by AGEs treatment, and the ratio of the apoptosis-related protein Bax/Bcl2 was elevated. Tetrazolium colorimetric assay shows the same results. Granulosa cells caused by AGE to induce apoptosis could be significantly reversed in KGN cells transfected with AMH siRNA. AMH and the Bax/Bcl2 ratio expression were reduced after SF1 expression was inhibited. Inhibition of the PI3K upregulated PCNA, SF1 and AMH expression. Additionally, in ovarian tissues of AGEs group and PCOS group, the expression of AMH and SF1 increased, accompanied with marked up-regulation of the phosphorylation of PI3K and Akt expression. And the ratio of Bax/Bcl2 increased, while the expression of PCNA was opposite.
Conclusions: AGEs increase the level of AMH (Anti-Mullerian Hormone) in ovarian granulosa cells, promoting apoptosis and restricting cell proliferation, thus leading to PCOS in rats. Studies suggest that SF1 may be a crucial target for AGE-mediated AMH production, involving the phosphorylation of the PI3K/Akt signaling pathway.
RETRACTED: Chiral Borohydride Complex Crystals: Synthesis, Structure and Reduction Application of Acetophenone
Authors: PAŞA Salih
Published: February 2024

The authors have requested that this preprint be removed from Research Square.
Health Inequality due to Changes in Income Following COVID-19: Preventive Activity
Authors: Kim Ji Eun , Han Kyu-Tae , Kim Sun Jung
Published: February 2024

Background
Preventive measures are crucial for improving the survival and quality of life of patients and reducing healthcare costs. The COVID-19 pandemic has induced various social changes, including to socioeconomic status, behavior, and income. We evaluated changes in income following COVID-19 as well as the effects on individual engagement in preventive activities.
Methods
Data from the 2021 Community Health Survey were used to select individuals aged 30–65 years who were involved in economic activities. We used logistic regression models to evaluate associations between changes in household income following COVID-19 and engagement in preventive activities.
Results
Of the 89,992 study participants, 36,193 (36.3%) experienced a decrease in household income due to COVID-19. Compared to individuals who had stable or increased income due to COVID-19, those whose income declined had a lower likelihood of participating in preventive activities, including vaccination(OR: 0.824, 95% CI: 0.794–0.856), medical checkups(OR: 0.625, 95% CI: 0.596–0.656), and cancer screening(OR: 0.815, 95% CI: 0.782–0.849). These differences were particularly significant in men and younger individuals, without chronic diseases and who were less satisfied with medical infrastructure.
Conclusion
Individuals who experienced a decreased in income due to COVID-19 encountered challenges in participating in prevention programs, leading to health inequality. For individuals with low rates of preventive activity, it is crucial to implement measures that encourage screening, such as providing incentives for individuals.
The relationship between long-term exposure to environmental NO2 and HDL levels among middle-aged and older adults in China
Authors: fang lu , Zhao Shuju , Liang Peng
Published: February 2024

Background
In recent years, an increasing number of studies have confirmed that air pollution mixtures can lead to abnormal levels of lipid proteins in the body. With the continuous deepening of research, the specific effects of different components in air pollution mixtures on human health have gradually begun to be explored. Nitrogen dioxide (NO2), as an essential component of air pollutants, hurts human health. Normal levels of high-density lipoprotein (HDL) play a crucial role in preventing cardiovascular diseases. However, the effect of environmental NO2 on HDL levels has yet to be further studied. Our study aims to explore the potential association between environmental NO2 exposure and HDL levels in middle-aged and elderly populations aged 45 and above in China.
Methods
Our research subjects are the third-wave China Health and Retirement Longitudinal Study (CHARLS) participants. This cross-sectional study analyzed the personal data of 12519 participants aged 45 and above with venous blood samples. The participants' high-quality and high-resolution NO2 exposure concentration data were obtained from the Chinese Air Pollutants (CHAP) dataset, and the HDL levels were obtained from the analysis results of venous blood samples. Multiple linear regression analysis, supplemented by subgroup analysis, was used to explore the correlation between NO2 exposure concentration and HDL levels.
Results
This cross-sectional study found a negative correlation between long-term exposure to air NO2 and HDL levels. The observed correlation between air NO2 and HDL levels indicates that middle-aged and older adults living in areas with high NO2 concentrations exhibit a decrease in HDL levels (Beta: -0.132; 95% CI: (-0.153, -0.111); P < 0.0001). This association still exists after considering various potential confounding factors (Beta=-0.103, 95% CI: -0.124, -0.083, p < 0.0001).
Conclusions
Our research results show a significant negative correlation between long-term exposure to high concentrations of NO2 and HDL levels in the middle-aged and elderly population in China.
Experimental Investigation on the Effect of Time on Transfer Length in Pre-Stressed Concrete Beams
Authors: Naghipour Morteza , Daronkolae Kosar Kolagar , Yousefpour Hosein , Hasani Seiyed Mohammadreza
Published: February 2024

The effect of time on of transfer length variations in prestressed concrete elements has not been addressed in the current design codes of practice. The present investigation examines the effect of different parameters on transfer length over time. Therefore, a number of 13 pretensioned concrete beams were made in the laboratory with differences in beam cross-section and length, strand number and arrangement, concrete cover, and strand eccentricity. The 95% AMS technique was used to calculate transfer length. The results showed that transfer length of all beams increases over time, the highest measure was experienced between 14 and 28 days after strand detensioning. This value ranged between 2 and 5% in single-strand beams, and 12 to 14% in 10-strand beams. It was concluded that strand eccentricity has no considerable effect on the transfer length variations. The beam live end captured higher transfer lengths in most of the beams; however, strand arrangement and the amount of concrete cover were found to have the potential to shift higher transfer lengths to beam dead end. It was also revealed that beam length plays a significant role on transfer length, while longer beams featured larger transfer lengths. The percentage of increase in the transfer length in 10-strand beams after 14 days reached approximately twice that of the single-strand counterparts. The reason was associated with the number of strands, cross-sectional dimensions, and strand arrangement.
Global Insights: A Bibliometric Analysis of Artificial Intelligence Applications in Rehabilitation Worldwide
Authors: Azizan Azliyana
Published: February 2024

Background: Rehabilitation plays a vital role in helping patients recover functionality after illness or injury. However, challenges remain in providing customized, accessible rehabilitation services. Artificial intelligence (AI) techniques like machine learning are emerging as promising tools to enhance rehabilitation. This study aimed to conduct a bibliometric analysis to synthesize global growth trends, research foci, and collaborative patterns in AI rehabilitation research.
Methods: A systematic literature search was performed in Scopus and Web of Science databases to retrieve peer-reviewed publications on AI in rehabilitation from 2000-2022. Articles were analyzed using ScientoPy, VOSViewer and Biblioshiny to extract publication volume, citations, authorship, journals, conceptual themes, and country networks.
Results: The search yielded 315 articles with exponential growth since 2016. Machine learning and deep learning were dominant techniques applied in rehabilitation contexts like stroke. China led research productivity, but contributions came globally including the US, Italy, India and others. Core journals were IEEE Access and IEEE Transactions in neural engineering and informatics. Citation trends highlighted pioneering AI system studies as most impactful.
Conclusions: This bibliometric analysis provides the first detailed mapping of global AI rehabilitation research, revealing rapid advances primarily in algorithm development rather than clinical translation. Findings can guide future growth through: (1) increasing focus on real-world implementation, (2) expanding applications to more health conditions and populations, (3) fostering cross-country and cross-sector collaboration, and (4) promoting commercialization. Sustained international effort is key to realizing AI's potential in enhancing rehabilitation outcomes. This study offers an evidence base to track evolution and set priorities in this emerging interdisciplinary domain.
Designs of the divider and special multiplier optimizing T and CNOT gates
Authors: Fan Ping , Li Hai-sheng
Published: February 2024

Quantum circuits for multiplication and division are necessary for scientific computing on quantum computers. Clifford + T circuits are widely used in fault-tolerant realizations. T gates are more expensive than other gates in Clifford + T circuits. But neglecting the cost of CNOT gates may lead to a significant underestimation. Moreover, the small number of qubits available in existing quantum devices is another constraint on quantum circuits. As a result, reducing T-count, T-depth, CNOT-count, CNOT-depth, and circuit width has become the important optimization goal. We use 3-bit Hermitian gates to design basic arithmetic operations. Then, we present a special multiplier and a divider using basic arithmetic operations, where 'special' means that one of the two operands of multiplication is non-zero. Next, we use new rules to optimize the Clifford + T circuits of the special multiplier and divider in terms of T-count, T-depth, CNOT-count, CNOT-depth, and circuit width. Comparative analysis shows that the proposed multiplier and divider have lower T-count, T-depth, CNOT-count, and CNOT-depth than the current works. For instance, the proposed 32-bit divider achieves improvement ratios of 40.41 percent, 31.64 percent, 45.27 percent, and 65.93 percent in terms of T-count, T-depth, CNOT-count, and CNOT-depth compared to the best current work. Further, the circuit widths of the proposed $n$-bit multiplier and divider are $3n$. I.e., our multiplier and divider reach the minimum width of multipliers and dividers, keeping an operand unchanged.
Deciphering the Geological Origins and Soil Properties of Loess-Like Silty Clay in the Yellow River's Middle and Lower Basins
Authors: Liu Zhenghao , Ma Xianfeng , Zhou Dingyi , Lu Linhai , Zhang Haihua , Bai Yujie , Han Han
Published: February 2024

This study systematically investigates the characteristics and geological genesis of loess-like silty clay in the middle and lower reaches of the Yellow River. The primary distribution of loess-like silty clay is revealed through field surveys, laboratory experiments, and previous literature reviews. The impact of the Yellow River's historical evolution on its sedimentary distribution is also examined. The chemical and physical properties of the loess-like silty clay were examined, in addition to investigations into its mineral composition, microstructural characteristics, and engineering mechanical properties, in order to enhance comprehension of its attributes and formation mechanisms. The research suggests that the distinctive soil environment in the area has been influenced by numerous instances of the Yellow River overflow and channel shifts over its history, as well as the impacts of climate change, geological factors, and human activities. The primary sources of material for the loess-like silty clay consist of loess, Hipparion Red Clay, and paleosol layers. The discussion also addresses the impact of regional climate on the formation of mineral components. The aforementioned findings hold significant implications for advancing the understanding of historical climatic and paleogeographic shifts, as well as for addressing engineering challenges associated with the distribution of loess-like silty clay.
An Analysis of Consumer Decision-Making in Mobile Payment Adoption: Exploring Influencing Factors
Authors: KAZAKOV TULKIN , Islam Mohammad Fakhrul , OSMAN ESAM , HOSSAIN MD BILLAL
Published: February 2024

Despite every one of the upsides of mobile payment services (MPs), they are unutilized by a sizable client base. This paper analyzes the central drivers of utilizing MPs for purchasing purposes from the consumers' point of view in Uzbekistan. Given the Technology Acceptance Model (TAM), the study built up a seven-figure model to uncover the determinants of customers' goals to utilize MPs. Risk, social influence, trust, hedonic motivation, and attitude were included in the conventional two-figure TAM show (system usefulness and facilitating conditions). 300 respondents in Uzbekistan were selected, and 276 substantial responses were incorporated into the analysis. The regression results applied that customers' goal to utilize MPs for purchasing purposes is impacted by trust, system usefulness, social influence, risk, hedonic motivation, and attitude. Facilitating conditions were not significant interestingly which is the most distinct finding of that particular study. the most grounded determinant of customers' acceptance of MPs. In light of the findings, the review demonstrates a few complications. Six factors (trust, system usefulness, social influence, risk, hedonic motivation, and attitude) can fill in as rules to support customers' adoption of MPs.
The CYP17A1 single-nucleotide polymorphism rs743572 in Iraqi polycystic ovary syndrome patients
Authors: Albedairy Iman H. , Aljawad Mohammed F. , AL-Shammari Jasim M. , Alshareefi Alyaa F.
Published: February 2024

Polycystic ovarian syndrome (PCOS) has been found to be one of the most prevalent endocrine disorders among women of reproductive age. Genetic factors play a crucial role in the pathogenesis of PCOS. CYP17A1 gene coded for (steroid-17-α hydroxylase/17, 20 lyase) is responsible for androgenesis. This study was aimed to investigate the relationship of CYP17A1 polymorphism with polycystic ovarian syndrome susceptibility from Iraqi women. A case-control association study involving 83 healthy participants and 80 PCOS patients was carried out. Using the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method, the restriction endonuclease MSpAI was used to genotype the SNP rs743572 (T/C) polymorphism on genomic DNA. The statistical analysis was conducted to identify the CYP17A1 polymorphism in PCOS. The most frequent genotypes in patients and control were (T/T) and (T/C) respectively, while (T) the most frequent allele in both patients and control. The inheritance of this SNP in PCOS was under codominant, additive and dominant models. Ultimately, it has been demonstrated that the C allele provided protection. The ‘TT’ genotype was associated with PCOS patients. Further studies need to include more samples to find out the effect of this SNP on PCOS patients.
Polarization of Religious Issues in Indonesia’s Social Media Society and Its Impact on Social Conflict
Authors: Faizin Barzan , Fitri Susanti Ainul , AS Enjang , Maylawati Dian Sa’adillah
Published: February 2024

In this new media era, people use social media to share information and discuss political, social, and religious issues that have pros and cons groups. In Twitter’s hashtags and tweets, religious issues frequently trigger a hot conversation that leads to netizen disputes and street movements in society. This study is intended to reveal the religious issues that often trigger polarization among Twitter users and how they influence horizontal conflict in society. This research applies mixed-method with social media analytics to conceal religious issues in Indonesia's social media society. The data collection was done by crawling data from the Indonesian Twitter users’ tweets regarding religious issues hashtags, which is a reference for further analysis. The research findings show that the top ten religious issues widely discussed based on 23,433 Twitter users’ tweets are the hashtags (#) salafi, wahabi, intoleransi (intolerance), komunisme (communism), taliban, anti-Pancasila, politisasi agama (politicization of religion), politik identitas (identity politics), radikalisme (radicalism), and pro khilafah. In many social conversation networks, the issues are related to each other and other issues of political figures, the three presidential candidates, the general election, and the Republic of Indonesia presidential election in 2024. And concerning these issues, Twitter users believe that the issues, good or bad, do not influence them. However, they believe that religious issues impact horizontal conflicts in society. Finally, it is hoped that further studies will elaborate on religious issues on other social media to capture the big picture of how netizens perceive religious issues.
Efficacy of short-term intensive home-based cognitive training combined with physical exercise in older adults: a single-arm trial
Authors: Lim Ikhyun , Shin Seyoung , Baek Hongseok , Park EunYoung , Hong Jeong Min , Kim Jong Moon , Kim MinYoung
Published: February 2024

Background Previous studies note the significant effects of Cognitive Training (CT) on older adults, but achieving consensus on optimal dosage is challenging due to intervention protocol heterogeneity. Short-term training seems preferable for clinical use due to potential elderly dropout during long-term intervention
Aims To evaluate the efficacy of 4-week intensive home-based cognitive and physical training on personal function in older adults.
Methods This prospective single-arm intervention study enrolled older adults aged ≥65 years who were capable of independently performing activities of daily living. Adults with a Mini-Mental Status Examination (MMSE) score of <24 points, a history of any brain injury, or difficulty in continuing the intervention were excluded. The training program comprised 1–2-hour cognitive tasks and 1-hour physical exercise for 5 days per week for 4 consecutive weeks. The MMSE, Repeatable Battery for the Assessment of Neuropsychological Status (RBANS), Berg Balance Scale (BBS), and modified Barthel Index (MBI) scores were assessed before and after the intervention. Functional outcomes were analyzed according to compliance level.
Results Twenty-five participants were enrolled and completed the trial. After the intervention, functional improvements were observed, along with significantly increased MMSE, RBANS-attention, BBS, and MBI scores (Ps<0.05). The high-compliance group showed greater increment in RBANS-memory and BBS scores than the low-compliance group (Ps<0.05).
Discussion The intervention in this study might have contributed to ADL in ambulation and bathing by enhancing the balance function
Conclusion Short-term intensive cognitive training combined with physical exercise seems to be effective in enhancing multifaceted functional status in older adults.
Evaluation of Settlement Development and Future Challenges in The Tsunami Disaster Risk Area Case Study: Banda Aceh Coastal Areas
Authors: Soviana Widya , Achmad Ashfa , Syamsidik Syamsidik , Rachman Firmansyah , Munirwansyah Munirwansyah
Published: February 2024

The cataclysmic tsunami in 2004 profoundly impacted the city of Banda Aceh, resulting in significant redevelopment efforts in the coastal areas. This research examines the spatial development of settlements in these regions, mainly focusing on their vulnerability to future tsunami hazards. Surveys, literature reviews, and Geographic Information System analyses assessed how current urban growth aligns with the directives outlined in the Regional Spatial Layout Plan and disaster mitigation strategies. The findings reveal a notable escalation in settlement development within Banda Aceh City, with a 73.70% increase in directed sites. However, establishing sufficient tsunami rescue facilities has yet to accompany this growth adequately. Only 3.4% of the population has access to vertical evacuation infrastructure, highlighting inadequacies in the city's preparedness for future tsunami events. This deficiency in safety infrastructure poses an elevated risk to the expanding population residing in these areas. The study underscores the need to reassess urban planning and disaster mitigation strategies comprehensively. We emphasize the urgent requirement for the government to implement policies regulating urban expansion in high-risk coastal areas and enhancing the availability and distribution of vertical evacuation facilities. These measures are of utmost importance in safeguarding the lives of Banda Aceh's residents against potential future tsunamis, thereby contributing to the city's sustainable urban development and resilience. The study also provides valuable insights and recommendations for government policymaking in urban planning, focusing on prioritizing the safety and well-being of coastal communities in regions prone to tsunamis.
Multipartite entanglement in the XXZ model with Dzyaloshinskii-Moriya interaction and external fields
Authors: LIMA LEONARDO DOS
Published: February 2024

In this paper, we investigate the quantum entanglement on spin-1/2 one-dimensional XXZ chain with Dzyaloshinskii-Moriya interaction (DMI) together with staggered and uniform magnetic fields on x and z directions, respectively. We use the well known mapping of this model on the sine-Gordon theory to calculate the quantum entanglement quantifiers as von Neumann entropy and entanglement negativity, which provides a useful framework for studying the emergence of quantum correlation in this model. How the behavior of the spin velocity implies in a significant impact on energy of elementary spinons excitations carrying spin S z = ±1/2, since that the DMI interaction and external fields generate a large effect on behavior of the spin velocity, we get a large influence of these coupling on quantum correlation what implies in an effect on development of quantum technologies based on this spin system.
Disentangling apricot genetic diversity in the Algerian semiarid agrosystem: Impact of graft-propagated autochthonous and introduced cultivars in a traditional seed-propagated system
Authors: Atek Younes , Egea Jose A. , Nicolás-Almansa María , Salazar Juan A. , Bahlouli Fayçal , Gómez Pedro Martínez
Published: February 2024

Despite the apricot cultivars introduced from Spain and France are displacing the autochthonous Algerian cultivars in each area, there are a lot of local cultivars that still have a great interest and they are cultivated in the orchards from the Algerian arid agrosystem. This study addresses the agronomical and molecular characterization of autochthonous (Algerian and Tunisian cultivars) and introduced (Spanish and French) graft-propagated apricot cultivars in a traditional seed-propagated system. Sixty-five apricot cultivated autochthonous and introduced accessions from the provinces of Batna (slightly arid area) and M´Sila (semiarid area) in Algeria have been evaluated. These cultivated accessions included autochthonous Algerian cultivars (graft and seed propagated) selected over the years for its adaptation to warm Mediterranean climate and Spanish and French introduced cultivars (graft propagated). In these materials and agronomical evaluation of phenological (budburst, flowering and ripening date), pomological (fruit weight and yield per tree) and fruit quality (firmness and acidity) traits were performed together with a molecular characterization of the genetic diversity using SSR marks. Results showed the great diversity at agronomical and molecular level of this Algerian apricot germplasm. The seed-propagated autochthonous cultivars showed a lower yield per tree and fruit weight. Seed-propagated autochthonous also showed a longer fruit development and ripening cycle in comparison with the grafted cultivars with a later ripening date. Regarding fruit quality seed-propagated autochthonous cultivars present low firmness and high acidity compared with the rest. Results also showed the effectiveness of SSRs by the correct identification, detecting some synonymies and suggesting the origin of some autochthonous cultivars. These results will provide more in-depth information to develop a strategy for in-situ conservation of cultivars and to reduce gene flow from introduced material to ancient orchards. These materials would be interesting to modify some quality traits such as the acidity or firmness and drought resistance in apricot breeding programs.
Ovarian cancer derived extracellular vesicles promote the metastasis and angiogenesis by mediating M2 macrophages polarization
Authors: Tang Xue , Ma Chengbin , Wu Qiongwei , Yu Meng
Published: February 2024

Background
Extracellular vesicles involve in the interplay between the cancer cells and other cells (including tumor associated macrophages) surrounding the tumor microenvironment, to remodel the tumor microenvironment and subsequently regulate the tumor progression. However, the underlying molecular mechanism of these complicated crosstalk are still unclear.
Methods
Firstly, we explored the effect of tumor-associated macrophages (TAM) on the survival prognosis among patients with ovarian cancer. Then we isolated the extracellular vesicles derived from ovarian cancer cells (OV-EVs) through ultra-centrifugation, and then analyzed the effect of OV-EVs on regulating macrophages polarization in ovarian tumor and in whole peripheral blood. Meanwhile, we explored the roles of the OV-EVs induced macrophages in tumor progression through in vitro assay and in vivo assays.
Results
OV-EVs could be encapsulated by the macrophages and could induce macrophages into M2 phenotype. Meanwhile, the OV-EVs induced-M2 macrophage could promote the angiogenesis as well as the cancer metastasis in vitro and in vivo. In addition, OV-EVs induced macrophage could stimulate the angiogenesis in vivo through increasing the expression level of VEGF and the expression level of VEGFR in tumor.
Conclusions
The present study demonstrated that OV-EVs could induce the macrophages into M2 polarization and promote the metastasis of ovarian cancer. The study provides a new insight to understand the mechanism in ovarian cancer progression.
Retrospective survival analysis of intrathecal chemotherapy for meningeal carcinomatosis
Authors: Bai Ge , Bai Ying , Wang Yan , Zou Yueli
Published: February 2024

Background and Objectives: Leptomeningeal metastasis, also known as leptomeningeal carcinomatosis (LMC), a rare metastatic tumor in the central nervous system, has seen an increasing incidence in recent years. This rise is attributed to improved survival rates in patients with malignant tumors. However, the treatment of LMC remains a global challenge. Intrathecal chemotherapy, the primary treatment approach, lacks standardized guidelines. This study aims to assess the efficacy, safety, and prognosis of intrathecal methotrexate, cytarabine, and pemetrexed in treating LMC. Methods This retrospective analysis encompassed clinical data and cerebrospinal fluid (CSF) laboratory tests from 66 patients with LMC. The study also examined the adverse effects and prognosis following intracranial chemotherapy. Results Of the patients treated, 73.4% experienced clinical symptomatic relief, 73.5% showed normalization of intracranial pressure, and 52.8% had negative CSF cytology results. Moreover, 64.8% reported no discomfort, while 22.2% experienced mild adverse effects. Intrathecal chemotherapy significantly reduced CSF leukocytes and tumor cell counts, as well as protein levels, in patients with LMC. Notably, a median survival of 9.6 months was observed. Factors such as age, gender, and pre-treatment intracranial pressure did not influence survival in patients receiving intrathecal chemotherapy. However, patients receiving ≥ 10 times of intrathecal chemotherapy showed a significant prolongation of survival, with a P value < 0.05. Conclusion Intrathecal chemotherapy can improve clinical symptoms, decrease elevated intracranial pressure, and markedly reduce CSF tumor cells and meningeal damage in patients with LMC. Additionally, a comprehensive course of intrathecal chemotherapy can substantially improve survival rates, with a low incidence of serious adverse effects.
Sustainable Symbiosis: Navigating Green Energy Purchase Intentions and Consumer Comfort with Remotely Controlled Energy Management
Authors: Clark Melissa , Doll Jessica
Published: February 2024

Green energy is at the forefront of many discussions. Renewable energy sources and smart devices are options for those wishing to lessen their reliance on fossil fuels. This study considers consumer perceptions of green energy when offered from an energy provider. Based on the theory of planned behavior (TPB), it is proposed that several variables such as environmental attitude, environmental self-identity, green history, subjective norms, and perceived behavioral control will lead to positive purchase intentions. The study also considers the variables’ effects on remotely controlled energy use (RCEU). The results indicate that environmental attitude, environmental identity, green history, and perceived behavioral control are all positively related to purchase intentions. Additionally, environmental attitude, green norms, and perceived behavioral control are positively related to RCEU. The results could have important implications for practitioners in the energy sector and citizens interested in environmental issues.
Hepatic Sirt6 protects against cholestatic liver disease primarily via inhibiting bile acid synthesis rather than antioxidation or triggering mitochondrial biogenesis
Authors: Zhang Wen , Wang Jiahui , Yang Luyao , Shao Yuyun , Peng Hongjun , Jiang Longfeng , Sheng Liang
Published: February 2024

Cholestatic liver disease, caused by accumulation of hazardous bile acids in the liver, may result in cirrhosis, fibrosis, or liver failure. Activation of Sirt6 prevents cholestasis-associated pathological events such as oxidative stress and mitochondrial biogenesis disorders and inhibits bile acid synthesis to alleviate cholestatic liver injury. However, it is still uncertain which route is responsible for the therapeutic effect of Sirt6 in reducing cholestasis. For this reason, we administered liver-specific Sirt6 knockout mice with N-Acetylcysteine, Keap1-Nrf2-IN-1 or acadesine to remove oxidative stress and/or trigger mitochondrial biogenesis after cholestatic liver disease modeling, but these measures did not significantly improve cholestatic symptoms. Unlike the antioxidant or triggers of mitochondrial biogenesis, MDL801, a Sirt6 agonist suppressing CYP7A1 expression and down-regulating serum bile acid levels, exhibited favorable therapeutic effects. It suggests that inhibition of hepatic bile acid synthesis is the main pathway by which Sirt6 alleviates cholestatic liver disease. These findings provide a solid basis for the possible application of Sirt6 agonists in the treatment of cholestatic liver disease.
Economic cost of mortality risks: a comparison between COVID-19 and air pollution
Authors: Reis Lara Aleluia , Emmerling Johannes , Tavoni Massimo
Published: February 2024

Air pollution is Europe's foremost environmental health threat, as highlighted by the European Environmental Agency. The COVID-19 pandemic has underscored the serious implications of air pollution and its potential to exacerbate diseases, including COVID-19, which could increase mortality rates. Both air pollution and COVID-19 disproportionately affect the elderly and those with pre-existing respiratory conditions. Despite this similarity, governments have been more effective in addressing COVID-19 mortality than air pollution. This discrepancy may be due to the perceived risk of COVID-19 being much higher than that of air pollution, even though air pollution may cause twice as many deaths annually. With projections estimating over 9 million deaths by 2050 due to air pollution, and considering the long-term impacts of climate change, urgent action is needed. The COVID-19 crisis has demonstrated the possibility of swift policy response with long-term economic considerations, presenting a critical opportunity for green policy initiatives. As the pandemic wanes, the urgency to leverage this momentum for environmental policy, particularly to combat air pollution and climate change, becomes more pressing, underscoring the significant health benefits of such actions.
Molecular classification of geriatric breast cancer displays distinct senescent subgroups of prognostic significance.
Authors: Wu Xia , Che Mengxin , Liu Kang , Wu Yixin , Feng Yun , Fu Shiting , Xu Huaimeng , Zhao Yongqi , Lin Feilong , Lin Liang , Ye Shihui , Lin Junqiang , Xiao Taiping , Li Wenhao , Lou Meng , Lv Hongyu , Qiu Ye , Yu Ruifan , Chen Wenyan , Li Mengyuan , Feng Xu , Luo Zhongbing , Guo Lu , Zhao Limin , Ke Hao
Published: February 2024

Elderly breast cancer presents distinct biological characteristics and clinical treatment responses compared to younger counterparts. According to National Comprehensive Cancer Network (NCCN) guidelines, a Comprehensive Geriatric Assessment (CGA) is recommended to develop specialized treatment plans and evaluate treatment efficacy in elderly cancer patients, based on physiological classification. However, the investigation into molecular classification in older cancer patients, which contributes to predict prognosis and guide therapeutic responses, is still lacking. In this study, we identify two subgroups displaying distinct senescent clusters among geriatric breast cancer patients through multi-omics analysis. Utilizing various machine learning algorithms to classify these two senescent clusters, we develop a comprehensive scoring model called 'Sene_Signature'. This model exhibits a better prognosis prediction for geriatric breast cancer patients than other established methods. For clinical therapeutic response prediction, Sene_Signature is shown to be correlated with tumor immune cell infiltration, which is supported by single-cell transcriptomics, and our RNA sequencing and pathological data. Furthermore, we identify increased drug responsiveness in patients with a high Sene_Signature to treatments targeting the EGFR and cell cycle pathways. Additionally, we establish a user-friendly web platform (http://zhaoliminlab.cn:8080/GBC/index.jsp) facilitating investigators in assessing potential patient Sene_Signature and treatment responses for elderly breast cancer patients based on their own sequencing data. In conclusion, we introduce a novel Sene_Signature as a means to evaluate prognosis and therapeutic response in elderly breast cancer patients. This offers a potential molecular classification that aids in the pre-treatment assessment of geriatric breast cancer.
The footprint of nuclear saturation properties on the neutron star f mode oscillation frequencies: a machine learning approach
Authors: Kumar Deepak , Malik Tuhin , Mishra Hiranmaya
Published: February 2024

We investigate the intricate relationships between the non-radial f mode oscillation frequencies of neutron stars (NS)s and the corresponding nuclear matter equation of state (EOS) using a machine learning (ML) approach within the ambit of the relativistic mean field (RMF) framework for nuclear matter. With two distinct parameterizations of the Walecka model, namely, (1) with non-linear self interactions of the scalar field (NL) and, (2) a density dependent Bayesian model (DDB), we perform a thorough examination of the f mode frequency in relation to various nuclear saturation properties. The correlations between the f mode frequencies and nuclear saturation properties reveal, through various analytical and ML methods, the complex nature of NSs and their potential as the cosmic laboratory for studying extreme states of matter. A principal component analysis (PCA) has been performed using mixed datasets from DDB and NL models to discriminate the relative importance of the different components of the EOS on the f mode frequencies. Additionally, a Random forest feature importance analysis also elucidates the distinct roles of these properties in determining the f mode frequency across a spectrum of NS masses. Our findings are further supported by symbolic regression searches, yielding high-accuracy relations with strong Pearson coefficients and minimal errors. These relations suggest new methodologies for probing NS core characteristics, such as energy density, pressure, and speed of sound from observations of non-radial f mode oscillations of NSs.
Dexmedetomidine impacts IDO1 and CHRM3 in breast cancer
Authors: Luo Jie , Cao Hong
Published: February 2024

Background
As the most invasive breast cancer (BrCa), triple-negative BrCa (TNBC) has the worst survival. The use of dexmedetomidine potentially affected BrCa surgery and dexmedetomidine was reported to have direct effects on TNBC cells. The objective of this study is to explore the mechanisms underlying the effect of dexmedetomidine on TNBC.
Methods
Dexmedetomidine targets were predicted using The Cancer Genome Atlas data SwissTargetPrediction. Cell lines MDA-MB-231, MCF7, and MCF10A were used to validate the targets in TNBC with both clinical samples and cell lines. Cancer cell lines and normal breast cell lines were grouped in cancer and normal groups respectively. Both groups were exposed to dexmedetomidine treatment. Cell Counting Kit-8 was used to determine the effect of dexmedetomidine on cells with target silencing. The binding model of the candidate targets was docked and critical amino acids were mutated to validate the binding model.
Results
Dexmedetomidine selectively inhibits cancer cells. Catalytic subunit of the DNA-dependent protein kinase (PRKDC), indoleamine 2,3-dioxygenase 1 (IDO1), opioid receptor kappa 1 (OPRK1), glutaminyl-peptide cyclotransferase (QPCT), macrophage migration inhibitory factor (MIF), potassium voltage-gated channel, subfamily H (Eag-related), member 2 (KCNH2), cholinergic receptor, muscarinic 3 (CHRM3), and potassium intermediate/small conductance calcium-activated channel, subfamily N, member 4 (KCNN4) were identified as dexmedetomidine targets in TNBC. The expression levels of PRKDC, IDO1, MIF, KCNH2, CHRM3, and KCNN4 were found to be upregulated in TNBC tissues compared to non-TNBC tissues(p < 0.05). Silencing of these genes was found to reduce the sensitivity of TNBC cells to dexmedetomidine(p < 0.05). This effect was counteracted when the silenced genes were overexpressed, resulting in an increase in the sensitivity of cells to dexmedetomidine (p < 0.05). Furthermore, a direct interaction between dexmedetomidine and IDO1 and CHRM3 was observed, which regulated the sensitivity of cells to dexmedetomidine(p < 0.05).
Conclusion
IDO1 and CHRM3 are direct targets of dexmedetomidine in TNBC.
High-resolution SIMS U-Th-Pb geochronology of small-size (<5 μm) monazite: Constraints on the timing of Qiuling sediment-hosted gold deposit, South Qinling Orogen, central China
Authors: Chen Lei , Hofstra Albert H. , Li Xian-Hua , Li Qiu-Li , Liu Yu , Ling Xiao-Xiao , Liu Xiao-Yan , Jian Wei
Published: February 2024

Accurately determining the timing of hydrothermal mineralization for sediment-hosted disseminated gold (SHDG) deposits is difficult because of a lack of both suitable chronometers and in situ techniques with the required spatial resolution and precision. The lack of precise age determinations on gold deposits has hindered understanding of their genesis and relation to the geodynamic setting. The Qiuling-Jinlongshan deposit is a typical SHDG deposit located in the eastern South Qinling Orogen (SQO), with 109 t Au at an average grade of 6.17 g/t. Devonian and Carboniferous metasedimentary rocks host structurally controlled gold mineralization, which is associated with silica-carbonate alteration. Pyrite, arsenopyrite, and arsenian pyrite are major gold carriers, and gold also occurs as native gold grains and invisible gold in the sulfides. In this study, the well-defined hydrothermal overgrowth rims (~2 μm) of single monazite grains, associated with disseminated auriferous arsenian pyrite and arsenopyrite in low-grade metasedimentary rocks, yield U-Pb ages of 239 ± 13 Ma (2σ) by high spatial resolution secondary ion mass spectrometry (SIMS). The hydrothermal monazites are cogenetic to the primary gold mineralization where they are closely associated with gold-bearing sulfides. This new age implies that the early to middle Triassic mineralization event in the eastern SQO was related to the Triassic tectonic transition from compression to transpression in the Qinling Orogen after the closure of the Mianlue Ocean. This study highlights the 2-μm high spatial resolution SIMS monazite U-Th-Pb dating method as a powerful tool for determining the timing of SHDG deposits worldwide. It is crucial to examine monazite textures and their link to hydrothermal alteration before carrying out the isotopic dating of monazite.
Localização, especialização e concentração das atividades produtivas no Mato Grosso do Sul entre 1980 e 2010
Authors: Nogueira Duarte Vilmar , Reinaldo Alves Lucir
Published: February 2024

O objetivo deste estudo foi analisar a localização, especialização e concentração das atividades produtivas no Mato Grosso do Sul entre 1980 e 2010. Utilizou-se da regionalização de Áreas Mínimas Comparáveis (AMCs) para que fosse possível fazer comparações espaciais intertemporais no período e estimou-se o Quociente Locacional (QL) para verificar as mudanças espaciais de concentração e especialização. Os resultados mostram que as atividades agropecuárias foram as mais difundidas espacialmente no Mato Grosso do Sul, com as AMCs de Campo Grande, Corumbá, Douradina e Selvíria apresentando as estruturas produtivas mais diversificadas. Por fim, a conclusão foi de que as atividades econômicas são concentradas espacialmente no MS, com as AMCs com estruturas produtivas mais diversificadas sendo também as mais desenvolvidas.
“Will I Die Now?” Mystical Experiences in Individuals with COVID-19 after a Near-Death Experience
Authors: Himawanti Izza , Faiq Muhammad
Published: February 2024

Near-death experiences (NDEs) are closely related to emotional and spiritual dimensions, even though they are subjective. This study aims to reveal the mystical experiences of individuals suffering from COVID-19 after NDEs. This article is qualitative research with a phenomenological approach. With purposive sampling, the data were collected from individuals suffering from COVID-19 who experienced NDEs but recovered. The data were then analysed with interpretive phenomenological analysis (IPA). This study reveals that when individuals experience NDEs, they no longer see and feel their physical body but their spirit or soul. They also have mystical experiences, such as being visited and communicating with specific religious figures and even the spirits of people who had died. After NDEs, a comprehensive reconstruction occurs regarding their personal beliefs and values regarding life and death, especially their relationship with God.Contribution: This study contributes to revealing the mystical experience of people after near-death experience (NDE). This study can be a recommendation, counselling, therapy and various psychological and religious interventions for individuals who experience NDE to accept their death more easily.
Between Legalism and Mystical Intuism: Sunan Kalijaga’s Qibla Direction in Pati and Demak Grand Mosque
Authors: Nurkhanif Muhammad , Raharjo Raharjo , Musyafak Najahan
Published: February 2024

This study aims to discover the process of determining the direction of the qibla by Sunan Kalijaga (one of Walisongo), employing a mystical and intuition (divine inspiration) method. This study is a qualitative field research using a socio-cultural approach. The research objects are the Baiturrahim Gambiran Pati Mosque and Demak Grand Mosque, Central Java. These mosques were built by Sunan Kalijaga. The results of this study revealed why the people of Gambiran Pati and Demak Grand Mosque still use the Sunan Kaljaga version of the qibla direction compared to the qibla direction using scientific technology. Some factors that influence include, first, the historical value factor of the Baiturrahim Mosque and Demak Grand Mosque as the guardian mosque and also the legendary figure of Sunan Kalijaga. Second, The socio-cultural characteristics of the Gambiran Pati and Demak communities are familiar with the mystical Kejawen.Contribution: This research contributes to understanding the method of determining the direction of the qibla by Sunan Kalijaga using mystical and intuitive approaches. It focuses on two historical mosques, the Baiturrahim Mosque in Gambiran Pati and the Grand Mosque of Demak, considering their historical, religious, and socio-cultural factors.
Journey to Union: Exploring Ibn Arabi’s Nomadic Philosophy and Imaginal Spaces in Sufism
Authors: Bouchoir Tayeb , Acim Rachid
Published: February 2024

This paper sheds light on Ibn Arabi’s philosophy of journey, which takes place in an empty space where mystical characters, noble saints, Prophets and Messengers of God are given a chance to communicate and interact peacefully. Considering the hermeneutics’ approach to Sufi discourse and Gilles Deleuze’s concept of nomad thought, we aim to showcase that Ibn Arabi regards the Sufi wayfarers as “nomadic subjects” as long as they can journey to the inward and outward realms. The intersection of these two antagonistic realms— the realm of Seen (al-hiss) and Unseen (al-ghayb)— liberates the Sufi practitioners from spatio-temporal stagnation and transfers them to endless states and multiple becomings that later evolve into spiritual stations (maqāmāt) of stability and certainty.  Contribution: This article highlights the breadth of Ibn Arabi’s nomadic style of thought in shaping the spiritual journey, arguing that the need to unite with God is expressed through a new style of spiritual movement that occurs in an imaginal space where the Sufi is enabled to communicate via his/her heart with other absentees, including noble saints, Messengers of God and Prophets
The Revival Movement of the Idrisiyya Order in Indonesia
Authors: Sulaiman Sulaiman , Ula Miftahul , Faiq Muhammad , Machrus Machrus , Yusriyah Yusriyah , Ulfah Rokhmah
Published: February 2024

Sufism and ṭarīqa are often associated with awful and negative stigmas for generating laziness, stagnancy, and surrender to misery. Sheikh Fathurahman tackles these assumptions through the teachings of the Idrisiyya Order. This study is qualitative based research. The primary data were collected from books by Sheikh Fathurahman and his lectures uploaded on Youtube, observations, Focus Group Discussions, and direct and indirect interviews. This study found that Sufi revivalism, as initiated by Sheikh Fathurahman, has led to a positive movement. The presence of the ṭarīqa, especially the Idrisiyya Order, amid society has contributed to crucial social changes and innovations in some sectors, such as economics, education, and other social programs. Contribution: This study will give a new insight into the central teaching of taṣawwuf, such as zuhd and tawakkal as reinterpreted by Sheikh Fathurahman under the Idrisiyya Order so that ṭarīqa becomes the locomotive of social change amid Muslim society in Indonesia.