bluuebunny/crossref_metadata_2025 huggingface dataset:
المنظور البيولوجي للظواهر السياسية وبراديغم السياسة الحيوية
Authors: زكاوي نبيل
Published: July 2024

تسعى هذه الدراسة لإثبات قيمة منظور علوم الحياة لدراسة جوانب السياسة وذلك من خلال تحديد الأسس البيولوجية للسلوك السياسي، وكشف إسهام براديغم السياسة الحيوية في الأطر التفسيرية للاحتياجات والاستجابات السياسية. وتبحث الدراسة في مدى إسهام بيولوجيا الجسد البشري في تفسير الفعل السياسي وتوجيه القرارات السياسية، وذلك من خلال فك التشابك الجوهري بين عوامل الطبيعة البشرية والعوامل البيئية في توليد السلوكات الاجتماعية والسياسية، وتقديم دلائل على دور المحددات البيولوجية في تشكيل الاتجاهات السياسية المهمة، ومؤشرات على بروز وتنامي القرارات ذات الطبيعية البيوسياسية. توظف الدراسة مقترب التعقد في النظر للفرد، والتكامل المعرفي بين علمي الحياة والسياسة في مقاربة جسد الفرد كموضوع للتحليل السياسي. وبحكم أن الموضوع غير مطروق على المستوى العربي، سيما أن له طابعًا تجريبيًّا، فقد تم الاستناد إلى أدبيات الدراسات الغربية الأنجلوسكسونية المتقدمة في هذا الإطار. وقد خلصت الورقة إلى أن السياسة كنظام حياة هي أكثر تركيـبـًا مـن أن ترد إلى عامل واحد أساسي (البيئة أو الطبيعة البشرية)، حيث السلوك السياسي هو محصلة أيضا للخصائص الفردية فضلًا عن الترتيبات المؤسسية، كما بينت أن نهج السياسة الحيوية المتأسِّس على الخلفيات البيولوجية للسياسة بقدر ما يكشف أن التقدم الاجتماعي يعتمد إلى حد كبير على اكتشاف الطبيعة البشرية وإدماجها في تخطيط السياسات، بقدر ما قد ينحرف إلى تقييد البشر داخليَّا من خلال حبك العلاقات السياسية بالطبيعة البشرية.
دمج العلوم الاجتماعية والإنسانية في الأبحاث متعددة التخصصات
Authors: المسالمة باسل
Published: July 2024

واجهت المحاولات الأخيرة لدمج العلوم الاجتماعية والإنسانية (SSH) في برامج تمويل الأبحاث متعددة التخصصات تحديات بسبب عدد من العوائق. في برامج التمويل، مثل برنامج هورايزون 2020 التابع للاتحاد الأوروبي (EU Horizon 2020)، كانت العلوم الاجتماعية والإنسانية غائبة عن معظم دعوات تقديم الإسهامات. يُعيد هذا المقال النظر في دوافع السياسة الرئيسة من أجل تضمين أبحاث العلوم الاجتماعية والإنسانية في الأبحاث متعددة التخصصات. ومن خلال تحليل سياسة المبادرات الحديثة، يوضّح المقال أنّ صنّاع السياسات في جميع أنحاء العالم ما زالوا مترددين حول دور العلوم الاجتماعية والإنسانية. في حين تقرُّ جهات معنية كثيرة الحاجة إلى دمج أبحاث العلوم الاجتماعية والإنسانية لمواجهة تحديات المجتمع الأساسية، مثل: تغيُّر المناخ أو الهجرة أو الأمن القومي، فإنّ تمويل العلوم الاجتماعية والإنسانية محدودٌ، ويميل إلى التركيز على التدخّلات الاستراتيجية والحلول المفيدة. ومن خلال تفسير تنوّع أشكال التعاون بين التخصصات، يوصي المقال باتباع نهج أكثر حساسية للسياق لتمويل البحث، الذي يعترف بعدم تجانس البحث وتقلّبه في بيئات المعرفة المختلفة. نُشِرَ هذا المقال على أنه جزءٌ من مجموعة موضوعات حول مفهوم تداخل التخصصات.
Election Fiqh Ethics: Efforts to Prevent Polarization and Its Impact on the 2024 Election
Authors: Fauziyah Ulil , Rozaq Abd
Published: July 2024

Polarization in the implementation of elections, especially in 2024, has a very dangerous impact which has the potential to create divisions between ethnicities, religions, races and between groups. One of the efforts to prevent this and minimize negative impacts is by creating norms from a fiqh perspective considering that the majority is 85 percent of the population. Indonesia is a Muslim society. This research aims to explain election ethics from a fiqh perspective to prevent and minimize polarization in the implementation of the 2024 election and its impacts. By using qualitative descriptive methods and a literature approach, researchers will collect and examine data from various written sources to look for election ethics from a jurisprudential perspective in preventing polarization in the 2024 simultaneous elections. Fiqh ethics in preventing polarization are divided into two, namely universal ethics and partial ethics. Universal ethics include arranging good motivation, not violating existing rules, maintaining human values, bringing benefits and rejecting damage and being fair. Meanwhile, the partial ethics are ta'aruf, tafahum, tasamuh, ta'awun, mujjadi and takaful.
Sakinah Mawadah and Rahmah in QS. al-Rūm [30]: 21: Analysis of Qirāah Mubādalah Faqihuddin Abdul Kodir (L.1971)
Authors: Bunda Mutiara Fitri Cahya , Nafisah Mamluatun
Published: July 2024

The phenomenon of divorce in Indonesia increases every year with various problems faced in a family. As time goes by, problems and solutions to overcome these problems also change, so that solutions that were commonly used in the past to deal with current household disputes are not appropriate. If referring to the interpretation of QS. al-Rūm [30]: 21 does not yet fully contain an interpretation regarding the current phenomenon of the concepts of sakinah mawadah and rahmah. This paper tries to respond to this problem by analyzing the interpretation of the QS. al-Rūm [30]: 21 uses the Qirā'ah Mubādalah perspective. The results of this research include; First, the interpretation of QS. al-Rūm [30]: 21 in the perspective of mubādalah is Allah SWT. shows one of the signs of His greatness by creating for his servants couples (both husband and wife) of the same kind so that they both feel calm and at ease, and tend to each partner. Then, to obtain this calm and tranquility, Allah SWT. bring a sense of love and affection between the two. These are the signs of His greatness for a people who think. Second, in its literal pronunciation, the verse discusses men who obtain peace from their wives, but in terms of its meaning, this verse also applies to women who obtain peace from their husbands. This is emphasized in the phrase bainakum which shows the reciprocal meaning between husband and wife.
Economic Growth Mediates Village Funds And Original Local Government Revenue Towards Poverty In Regencies/Cities In East Java
Authors: Wibisono Nurharibnu , Abidin Munirul , Ekowati Vivin Maharani
Published: July 2024

Purpose:  The mean of its research was to examine the effect of Village Funds and Local Government Revenue (PAD) on poverty mediated by economic growth in regencies and cities in East Java province.Design/Method/Approach:  The research population is regencies/cities in East Java in 2015–2022. The data on Village Funds and Local Government Revenue were taken from the DJPK of the Ministry of Finance Republic Indonesia situs. The data on poverty and economic growth were obtained from the website of the Central Bureau of Statistics (BPS) of East Java Province. The data analysis used path analysis. Findings:  The outputs declare Village Funds had a significant positive influence on poverty. Village Funds have no significant influence on economic accretion. Local Government Income has a significant negative influence on poverty. Local Government Revenue has a significant positive influence on economic accretion. Economic increases has a significant positive influence on poverty. Village Funds have a significant positive indirect impact  on poverty by way of economic growth. Original Government Revenue has a significant positive indirect influence on poverty through economic increases.Originality/Values:  Economic growth must be encouraged because it is able to mediates village funds and original local government revenue towards poverty in regencies/cities In East Java.
Repurchase Interest Reviewed from Customer Experience and Service Quality with Consumer Satisfaction as an Intervening Variable
Authors: Yanti Yanti
Published: July 2024

Purpose: The research aims to determine the effect of customer experience, service quality, and cafe atmosphere on repurchase intention with consumer satisfaction as intervening variables for Bento Kopi.Design/Method/Approach: The type of approach taken in this research is quantitative. Data analysis techniques using Structural Equation Modeling with the SmartPLS analysis tool version 3.0. The objects in this research are consumers who have made purchases at Bento Kopi. The sampling technique uses nonprobability sampling and determining the sample used purposive sampling with a total sample of 100 respondents. Data collection was carried out by distributing questionnaires online with Google Forms.Findings: The findings of research results show that a direct customer experience has a positive and significant effect on repurchase interest. Meanwhile, service quality does not directly influence repurchase interest. Repurchase interest is influenced by customer experience and service quality through the use of consumer satisfaction as an intervening variable.Originality/Values: This research is the first research to determine repurchase interest in Bento Kopi Kudus as reviewed by customer experience and service quality with consumer satisfaction as a variable intervention.
Implementasi Model Blended Learning pada Mata Pelajaran Matematika dengan Media Whatsapp Peserta Didik di Sekolah Dasar
Authors: Septiani Sela , Prastowo Andi
Published: July 2024

Blended learning is a learning model that combines face-to-face learning with online learning. After the end of Covid-19, teachers continued to implement technology-based learning using WhatsApp media to introduce technology without abandoning face-to-face learning. This research aims to describe the implementation of blended learning models in mathematics subjects using WhatsApp media for students in elementary schools. This research uses a qualitative approach. Research conducted by researchers at Depok 1 State Elementary School on class IV students totaling 27 students. Data collection was obtained through interviews and observations. The research results showed that interactions that occurred via WhatsApp media facilitated discussions between teachers and students outside of face-to-face learning time. Planning is done by selecting materials, implementation is done by sending materials via WhatsApp, and evaluation is done by giving tests. Apart from that, WhatsApp also has obstacles, namely network constraints, support factors and parental control while in the home environment. The implications of the blended learning model using WhatsApp media are appropriate to apply, because WhatsApp is a familiar media and is one of the media that is easy to use. Technological developments are increasingly rapid, so teachers can introduce technology for education to students.
Changes in the epidemiological indicators of type 1 diabetes mellitus in children and adolescents living in the closed administrative and territorial entity
Authors: Taranushenko T. , Proskurina M. , Kiseleva N.
Published: July 2024

Type 1 diabetes mellitus (DM) (T1DM) in children remains one of the most important problems of endocrinology due to the constant increase in new cases of the disease. Objective. To analyze the main epidemiological indicators (morbidity and incidence rates) of DM among children and adolescents who live in the closed administrative-territorial entity (CATE) and to compare the data from the federal DM register with those in that of the Krasnoyarsk Territory and Russian Federation to assess trends and to plan further work on the provision of specialized medical care, as well as the rational use of material and human resources. Material and methods. The data of regional DM register in the past 10 years (2010–2021), as well as those in the outpatient records of T1DM who lived in the CATE of the Krasnoyarsk Territory were studied and analyzed. Morbidity and incidence rates were calculated; a comparative analysis was carried out. The data available in the register and medical documentation were analyzed and there was evidence for the age and gender characteristics of a manifestation of the disease. Results. The incidence of DM among the pediatric population in the CATE exceeded the average statistical indicators in the Krasnoyarsk Territory. The age structure of sick children was dominated by a 15–18-year group. The gender characteristics included higher morbidity rates among the boys in the entire group of the examinees. An assessment of the incidence of DM revealed its stable increase with the maximum figure by 2021. Conclusion. The presented data and the analysis of indicators can be used in further observations and for the comparison with future data on the incidence of DM in children in the CATEs.
VITAMIN D AND POLYNUCLEOTIDES IN THE TREATMENT OF OSTEOARTHRITIS
Authors: Kashpanov M. , Novikova I. , Pronkina A.
Published: July 2024

Osteoarthritis occupies a leading position among the causes of disability in patients with rheumatic diseases. The wide prevalence of pathology and the high risk of disability predetermine the need to prevent its development, improve the effectiveness of treatment and conduct rehabilitation measures. The article presents a clinical case on the use of vitamin D and its active metabolites, polynucleotide preparations in the treatment of osteoarthritis. Long-term intake of high doses of vitamin D leads to a decrease in the intensity of pain and functional deficit in patients with osteoarthritis. Vitamin D and its active metabolites compensate for the deficiency of cholecalciferol and thereby reduce the intensity of synovial inflammation in osteoarthritis, at maximum dosages demonstrate a chondroprotective effect by inhibiting apoptosis of chondrocytes, and in the early stages prevent non-adaptive remodeling of the subchondral bone. The results of fundamental and randomized clinical trials allow us to conclude that it is advisable to include vitamin D in the complex therapy of osteoarthritis. It is important to include vitamin D in complex therapy in the early stages of the disease. In addition, there is information in the literature about the use of polynucleotide preparations in the treatment of osteoarthritis. Against the background of treatment with polynucleotide preparations, it is possible to delay the time to arthroplasty, and the need to take non-steroidal anti-inflammatory drugs and opioids decreases.
Relationship of comorbidity to the severity of the course of the novel coronavirus infection in patients who have delivered in a District Clinical Hospital of Khanty-Mansiysk
Authors: Chernaya E. , Kasparova A. , Yanin V. , Kutefa E. , Vasilkovskaya E. , Chegus L. , Semenchenko S. , Hidirnebieva F.
Published: July 2024

Objective. To study the structure of somatic morbidity and comorbidity in pregnant
women living in the Khanty-Mansi Autonomous Area and to evaluate its impact on
the severity of the course of novel coronavirus infection (NCI) and the outcomes
of pregnancy.
Subjects and methods. A single-center prospective comparative study was
conducted in the groups of women who experienced NCI in the third trimester
from March 2020 to April 2022 (n=149). The patients were divided into groups:
1) mild NCI (without pneumonia) (n=78); 2) moderate NCI (n=52); 3) severe NCI
(n=19).
Results. A statistically significant relationship was found between the presence
of obesity concurrent with diseases of the urinary system, the upper respiratory
tract, and severe NCI (p=0.04). Chronic pyelonephritis in the patients’ history
was statistically significantly associated with oligohydramnios (p 0.001) and
gestational diabetes mellitus (GDM) (95% confidence interval, 1.070–8.883).
Conclusion. Ninety (60.4%) pregnant women who had experienced NCI were
found to have a history of somatic diseases; the comorbidity index was 1.9. The
concurrence of endocrine and urinary diseases with chronic upper respiratory
tract ones significantly worsened the course of NCI and led to placental disorders
and GDM.
Key words: obstetrics and gynecology, infectious diseases, pregnancy,
comorbidity, novel coronavirus infection, placental disorders, gestational diabetes
mellitus.
Markov model in evaluating the efficiency of various COVID-19 treatment regimens
Authors: Vdoushkina E. , Borodulina E. , Gladunova E. , Povalyaeva L.
Published: July 2024

Objective. To consider the evidence-based approaches to treating virus-associated lung tissue lesions, the rationale for using the Markov model to evaluate the clinical and economic efficacy of interleukin (IL)-6 (IL-6) receptor inhibitors in patients with COVID-19. Subjects and methods. To evaluate the clinical and economic effectiveness of using the receptor inhibitors in COVID-19 patients, the investigators formed two groups: 1) 187 patients received the standard therapy; 2) 104 patients had IL-6 receptor inhibitors in addition to the standard therapy. Results and conclusion. The logistic regression method was used to determine the need for prescribing these drugs depending on the individual characteristics of patients, the key points were the length of a patient's stay in the intensive care unit, as well as the duration of oxygen support. In the context of new challenges to the healthcare system, it is necessary to further search for comprehensive methods of monitoring the condition and prognosis with promising ways to assess the validity of using therapeutic procedures and drugs.
The quality of life in primary school children according to the teaching format and motor activity
Authors: Lebedenko А. , Ershova I. , Levchin А. , Rogovtsova A.
Published: July 2024

Objective. To study the impact of the duration of distance learning on the quality of life (QOL) in primary school children. Subjects and methods. An open cohort prospective study of primary school children and their parents was conducted using the Pediatric Quality of Life Inventory PedsQL 4.0ТМ. A study group included 182 children (and their parents) who had learned in the distance format for 6 months (Lugansk). A comparison group consisted of 234 primary school children (and their parents) who had had distance learning for 2 months (Rostov-on-Don). Results. The analysis of the results indicated that the first ranking place showing in discomfort and the greatest decrease in the QoL indicators in the study group was displayed by the physical functioning scale (6-month distance learning). The second ranking place belonged to school functioning, the level of which in the study group decreased by 1.27 scores compared to the baseline level. The third ranking place is shown by social functioning of primary school children, the indicators of which in the study group were 18.49 scores lower than the initial levels. Conclusion. Prolonged education of primary school children in a distance format affects all aspects of QOL. The greatest decrease in QOL indicators in younger schoolchildren during the formation of basic learning skills is observed in the field of physical, school and social functioning. The assessment of QOL by primary school children and their parents differs.
Psychocorrective and cardiotropic therapy in young men with hypertension, overweight and androgen deficiency
Authors: Khabibulina M. , Shamilov M.
Published: July 2024

Men with testosterone deficiency with hypertension and overweight were treated. A reliable result was achieved within six months of treatment with an ACE inhibitor and an "alternative" classical hormone replacement therapy drug Leveton, which has a positive effect on biological age, regulates metabolism, reduces psycho-emotional stress, increases social adaptation, mental performance, improves mood, normalizes sleep. Early detection and timely treatment make it possible to avoid possible complications of cardiovascular diseases, allows to increase the effectiveness of combination therapy with ACE inhibitors and Leveton in men with androgen deficiency and overweight with hypertension at the level of blood pressure, remodeling of the heart, the state of the vascular bed, erectile dysfunction, psychological state.
Prevention of airborne infection in operating rooms and dental offices: modern approaches and technologies
Authors: Brudyan G. , Yarikov A. , Tsybusov S. , Sosnin A.
Published: July 2024

In modern medical practice, the issues of asepsis and disinfection in operating and dental rooms are becoming particularly relevant in the context of preventing airborne infections. Given the rise in antibiotic-resistant microorganisms and the increasing number of invasive medical procedures, the need for effective methods of asepsis and disinfection is becoming more evident. The review covers contemporary approaches and technologies aimed at minimizing the risk of infectious complications. Methods of ventilation and air filtration, the application of ultraviolet sterilization, and laminar airflows are discussed. Special attention is given to their effectiveness in various medical fields, including dentistry and surgery. The aim of the review is to systematize existing knowledge and formulate recommendations for further scientific study and clinical practice.
Antioxidant Activity in Pharmaceutical Biotechnology Products in The Form of Formulations and Preparations of Telang Flower Kombucha Hand Soap (Clitoria ternatea L)
Authors: Maigoda Tonny Cortis , Hariadi Hari , Triyono Agus , Rezaldi Firman , Sugiono Sugiono , Saifullah Ipul , Munir Misbakhul , Kurniawan Maskun , Rohmatulloh Rizal , Yenny Ratna Fitry , Pamungkas Barolym Tri , Amin Suseno , Judiono Judiono
Published: July 2024

Free radicals need to be handled and even prevented so that they are not exposed to the skin, especially the hands. One solution to preventing the exposure of free radicals to the skin of the hands is to wash your hands with herbal soap which is made from the active ingredient of telang flower kombucha. Telang flower kombucha was designed as an active ingredient in the formulation and hand washing soap preparation in this research has been proven as a pharmaceutical biotechnology product in warding off free radicals. This research was designed by making a formulation and preparation of telang flower kombucha hand washing soap at concentrations of 20%, 30% and 40% then measuring it using UV-Vis spectrophotometry. Based on statistical analysis, especially post hoc analysis of pharmaceutical biotechnology products in the form of formulations and preparations of telang flower kombucha hand washing soap at a concentration of 40%, it is significantly different from 20% and 30% as a source of antioxidants.
Effectiveness Test of Saliara Leaf Extract (Lantana camara) on Escherichia coli Bacteria Kirby Bauer Disc Method
Authors: Baba Firda , Karim Marzelina , Sam Andi Dhedie Prasatia , Sodiqah Yani , Hatta Dhian Karina
Published: July 2024

Death due to infection is the most common cause and is a challenge in the health sector. In 2019, 7.7 deaths were due to bacterial infections, 90 to 100 cases were urinary tract infections and Escherichia coli bacteria contributed to 90% of urinary tract infections. This research uses the Kirby Bauer Disc method to determine the effectiveness of Saliara (Lantana camara) leaves against Escherichia coli bacteria. The type of research is a Laboratory experiment using the Kirby Bauer disc method with a post-test-only control group design. Data analysis uses recording of identifying the inhibition zones formed The research showed that a sample's concentration can influence the inhibition zone's resulting diameter. Saliara leaf extract with concentrations of 100%, 150%, and 200% produced an inhibition zone of 8.55 mm; 9.59mm; 12.34 mm in the proliferation of Escherichia coli bacteria. The positive control with the antibiotic ciprofloxacin produced an inhibition zone of 19.56 mm on the growth of Escherichia coli bacteria. Control with negative distilled water does not create an inhibition zone because it does not have antibacterial activity. The conclusion is moderate inhibitory activity in Saliara (Lantana camara L.) leaf extract at concentrations of 100% and 150%. It is strong at a concentration of 200% against the growth of Escherichia coli bacteria.
Learning Model Development of Disaster Mitigation for Elementary School Students at Lombok, Indonesia
Authors: Taufik, M.Si Muhammad , Sutrio Sutrio , Gunada I Wayan , Syahrial A Syahrial A , Doyan Aris , Susilawati Susilawati
Published: July 2024

A research study conducted in Lombok Island, Indonesia, developed a learning model for disaster mitigation for elementary school students. The model is based on a scientific approach and incorporates knowledge about natural disasters, their causes, and effects. Students are taught how to identify and respond to warning signs of a disaster, and the importance of being prepared for one. The study found that the learning model was effective in increasing students' knowledge, skills, and attitudes about disaster mitigation. Students who participated in the study were better able to identify the warning signs of a disaster and take appropriate action, as well as express a greater sense of preparedness for a disaster. The learning model can be used to educate elementary school students about disaster mitigation in other regions prone to natural disasters. Teachers can use various resources to teach students about natural disasters, provide opportunities for practice identifying warning signs and responding to disasters through role-playing exercises, and help students develop a sense of preparedness by discussing the importance of having a disaster plan and practicing what to do in the event of a disaster. By incorporating the learning model into their curriculum, teachers can ensure that their students are prepared to face the challenges of natural disasters
Lived Experiences of Cervical Cancer Patients Receiving Chemotherapy at Cancer Diseases Hospital in Lusaka, Zambia
Authors: Elisha Benkeni Kapya , Marjorie Kabinga Makukula , Mwaba Chileshe Siwale , Victoria Kalusopa Mwiinga , Elijah Mpundu
Published: July 2024

Background: Cervical Cancer poses a significant global health challenge, especially in lowresource settings. It is a significant health problem worldwide, with over half a million new cases diagnosed each year, accounting for approximately 6.6% of all gynecological Cancer cases and over 300,000 deaths each year. In Zambia, it is the leading cause of mortality and morbidity among women. The number of cases has increased by approximately 40%. This study explored the lived experiences of Cervical Cancer patients undergoing chemotherapy at the Cancer Diseases Hospital in Lusaka, Zambia, focusing on their subjective experiences. By examining their journeys through chemotherapy, the study aimed to highlight the subtle complexities in which treatment impacts patients’ lives and well-being. Methods and procedures: Employing a qualitative descriptive phenomenological study design, in-depth interviews were conducted with 10 participants with diverse demographics. The sample size was determined by data saturation and saturation was reached at 10. Ethical protocols were ensured, and Study approval was obtained from UNZABREC and the National Health Research Authority. Thematic analysis was conducted on audio-recorded interviews with cervical cancer patients, ensuring confidentiality and accuracy while discerning significant patterns and themes in their narratives. Results/findings: Emotional experiences ranged from anxiety to gratitude. Psychological challenges encompassed coping mechanisms, stress management, emotional adjustments, and treatment-related fears. Socially, community support, workplace accommodations, and healthcare provider roles were key. Physical experiences revealed side effects managed through coping strategies. Financial challenges significantly impacted individuals and families. Conclusions and recommendations: The study revealed that cervical cancer patients undergoing chemotherapy face complex challenges spanning emotional, psychological, social, physical, and financial domains, underscoring the imperative for comprehensive patient-centered care. Recommendations suggest focusing on financial aid for cancer patients and tackling treatment expenses and insurance issues. The Cancer Diseases Hospital should establish multidisciplinary teams for holistic care, and enhance patient education efforts. Nurses should adopt strategies integrating cultural competence and patient-centered care to address diverse challenges during chemotherapy. These aim to enhance the well-being and care quality of Cervical Cancer patients.
Molecular Mechanisms and Potential Predictive Biomarkers in Advanced Non-small Cell Lung Cancer: A Summary of Current and Future Trends
Authors: Isabella Sforzin , Juliana Rodrigues Beal , Fernando Moura
Published: July 2024

Non-small-cell lung cancer (NSCLC) accounts for 85% of lung cancer cases and is associated with different risk factors (smoking habits, gender, and age). In this scenario, many studies have been conducted to pursue improvement of survival, faster and better therapy response, reduced adverse events, and expanded available therapies and treatments against tumor resistance to drugs. These studies have focused on defining the most prevalent NSCLC biomarkers (EGFR, HER2, ALK, MET, ROS1, BRAF, KRAS G12C, HER3, NTRK, and NRG1) and their actionability. It is noteworthy that expressed kinase receptors can have overlapping mechanisms of activation of different pathways (JAK-STAT, MAPK, PI3K-AKT-mTOR, and PLC-c), which can lead to the same outcome of cell proliferation, migration, and survival resulting in increased tumor resistance to treatment. This review provides an overview of the latest findings regarding NSCLC treatment, emphasizing particular biomarkers and potential molecularly altered pathways implicated as targeted therapies. Additionally, it explores the clinical significance of the proposed treatments, their implication on progression-free survival, ongoing clinical trials, and their perspective of evolution so far.
Peer instruction’s Achilles’ heel: An analysis of its ineffectiveness in confronting counterintuitive physics questions
Authors: Ospanbekov Yerbol , Maxutov Samat , Sandybayev Yerbol , Boranbekova Aknur , Balta Nuri
Published: July 2024

This paper examines peer instruction, an educational technique that enhances student-student interaction and student-teacher interaction, influencing students’ performance on counterintuitive physics questions. The study employed a quantitative approach with 40 participants, 22.5% of whom were male and 77.5% were female. The counterintuitive dynamics test was used to measure students’ counter intuitions in dynamics. The study results on counterintuitive questions showed no noticeable effect from peer instruction. Surprisingly, more students shifted from correct to incorrect responses after group discussions, leading to a decrease in the overall accuracy rate. Although peer instruction did not show a clear impact on counterintuitive physics questions, it is important for educators to recognize the complexity of peer instructions. Exploring different teaching methods that use peer interaction might help improve learning outcomes for counterintuitive physics questions.
A systematic review of STEM teaching-learning methods and activities in early childhood
Authors: Revák Ibolya Markóczi , Csernoch Mária , Szilágyi Klára Czimre , Dávid Ágnes , Tóth Beáta Kosztin , Malmos Edina , Sütő Éva , Kurucz Dóra
Published: July 2024

This study aims to help educators and researchers to understand the pedagogical practice of STEM in early childhood and its impact. To support this, 29 publications related to STEM teaching-learning methods and activities were selected in the period between 2014 and 2023. The study covers the distribution of research over time by countries, the analysis of keywords, research goals and results, research methods, STEM domains, as well as emerging teaching-learning methods and activities, and the presentation of research limitations. According to the results, digital activities and impact studies have become dominant in early childhood STEM activities. There is a small number of studies presenting educational practices related to the relationship between sustainability and STEM. It was also revealed that impact assessments regarding early childhood STEM education need further development and improvement.
Transformational leadership and competitive strategies in mining companies
Authors: Gómez Romero José Gerardo Ignacio , Tortolero Portugal Rosalío , González Herrera María Brenda , Figueroa González Ernesto Geovani
Published: July 2024

Purpose: To stablish the existing relationship of transformational leadership in the competitive strategies of mining companies in Durango Mexico.Methodology: This study adopts a quantitative, correlational, and cross-sectional approach. To analyze the influence among variables, the linear regression analysis technique was employed. Data was collected through a questionnaire applied to a probabilistic sample comprising 378 workers. Findings: There is a statically significant relationship among variables. Besides, inspirational motivation is the most frequent dimension of transformational leadership and cost strategy is the most prevailing. Implications: The study revealed that mining companies should encourage transformational leadership due to the positive relationship it fosters in their competitive strategies.Value: The relationship found among variables enabled us to recognize that promoting inspirational motivation and intellectual stimulation will have a positive effect on cost strategy.
Challenges of Thyroidectomy Anaesthesia for a Huge Retrosternal Goitre in a Jehovah’s Witness: A Case Report
Authors: Ikokoh O , Ojo AK , Adisa AO , Oria AI , Ajefolakemi JO
Published: July 2024

In potential haemorrhagic surgical procedures, refusal of allogenic blood infusion poses a challenge to anaesthetists. This report is about a 65-year-old male, of the Jehovah’s Witness (JW) religious sect, known hypertensive, who presented with an anterior neck mass with retrosternal extension of three years. Laboratory investigations were normal, and the haemoglobin concentration was 13gm/dl. He consented to acute normovolaemic haemodilution (ANH). Therefore, two units of blood were drawn and replaced with isoplasma. The patient had a general anaesthesia relaxant technique. Intravenous tranexamic acid, morphine, and paracetamol were administered. A right-lobal thyroidectomy and sternotomy were performed. After securing haemostasis, the two blood units were infused, and the estimated blood loss was 1.5 litres. The surgery lasted for five and a half hours. After surgery, the patient was reversed of the neuromuscular blockade, extubated, transferred to the intensive care unit (ICU), and monitored for 24 hours. He had supplemental oxygenation, analgesia, and other supportive care. He was discharged on postoperative day seven and had attended the outpatient clinic for two months.
Machine Learning Based Compiler Optimization Technique
Authors: Iqbal Salwa , Sheikh Mr.Kashif
Published: July 2024

Since the last decade to upcoming era the need of machine learning based compilation approaches has become indispensable for every aspect of growing technology especially artificial intelligence and network computing areas. These approaches are used to enhance the result quality by their improved performance as well as handles compiler optimization problems namely optimization selection and phase ordering. It has enthused from a vague research place in middle of the road movement. Wealth of present compiler optimization techniques leads to finding the best heuristic parameters to tune each optimization tactic using machine learning. In this research paper, we highlighted the term machine learning and compiler along with relationship between compiler optimization and machine learning with the identity of the concept of models, training, and approaches.
Antimicrobial Activity and Molecular Docking of Benzoyl-N,N’-dialkylurea against Target Proteins in Microbial Cells
Authors: Diyah Nuzul Wahyuning , Warsito Gita Miranda , Isnaeni  , Hidayati Shabrina Wahyu
Published: July 2024

This research aims to evaluate the antimicrobial activity of benzoyl dialkylurea derivatives to meet the global need for new antibiotic lead compounds. Four compounds were tested in vitro against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Candida albicans by broth dilution method using ciprofloxacin and nystatin as standards. Docking simulations were performed to target essential proteins including DNA gyrase, FabH, RNA polymerase in bacterial cells and DHFR in C. albicans. BDMU, BEU1, BEU2, BEU3 exhibited antibacterial activity while BEU1 and BEU2 showed weak antifungal activity against C. albicans. The BDMU, BEU2, BEU3 considered promising growth inhibition against P. aeruginosa. In silico molecular docking on DNA gyrase from P. aeruginosa (PDB. 6M1S) was proposed as a model for mechanism of action in bacterial cells. The monobenzoyl of dialkylurea containing urea functionality with chloro-substituent at position-2 and 4 on aromatic rings were potential as lead compound to generate new antibacterial agent.
Perbedaan Frekuensi Aplikasi Handsanitizer Terhadap Jumlah Total Bakteri Telapak Tangan
Authors: Artanti Dita , Eka Sispita Sari Yeti , Vita Purwaningsih Nur , Riesti Retno Arimurti Anindita , Azizah Fitrotin , Rohmayani Vella
Published: July 2024

Virus Corona 2019, juga dikenal sebagai COVID-19, menyebar antar manusia melalui droplet atau cairan yang dikeluarkan saat batuk dan bersin dan menempel pada hal-hal di sekitarnya. Pandemi ini telah menjadi pandemi di seluruh dunia. Oleh karena itu, untuk mencegah penyebaran virus tersebut, setiap orang sekarang menjadi kebiasaan menggunakan sabun tangan. Hand sanitizer adalah antiseptik yang mengandung etil alkohol antara 60 dan 95 persen, dengan alkohol 70% yang paling umum digunakan. Tujuan penelitian ini adalah untuk mengetahui pengaruh frekuensi aplikasi cuci tangan menggunakan hand sanitizer terhadap jumlah total bakteri pada telapak tangan. Jenis penelitian ini adalah deskriptif. Populasi dalam penelitian ini adalah total bakteri pada telapak tangan yang diperiksa di Balai Besar Laboratorium Kesehatan Surabaya dengan sampel yang diambil sebanyak 21 swab telapak tangan dan dibagi menjadi 4 perlakuan (30 menit, 1 jam, 2 jam, dan 3 jam) dengan 1 kontrol. Hasil penelitian menunjukkan waktu aplikasi 30 menit pertumbuhan bakteri sebesar 970000 CFU, 1 jam sebesar 1410000 CFU, 2 jam sebesar 4788 CFU, 3 jam sebesar 18002 CFU. Waktu semprot yang paling efektif adalah penggunaan hand sanitizer dengan waktu penyemprotan yaitu 2 jam sekali dengan hasil 4786 CFU. Data yang diperoleh dianalisis menggunakan uji kruskall-wellis hasil probabilitas menunjukkan nilai signifikansi ρ= 0.754. Jadi terdapat pengaruh yang signifikan dalam pengaruh frekuensi aplikasi cuci tangan menggunakan hand sanitizer terhadap total bakteri pada telapak tangan.
Terapi Senam untuk Mengurangi Keluhan Selama Masa Nifas
Authors: Nadhiroh Aim matun
Published: July 2024

Objective: Most postpartum mothers experience a decrease in their physical, psychological and social conditions while carrying out their new role as mothers. This will affect their psychological condition. Yoga is an alternative to complementary therapy to improve and stabilize the mother's psychological condition. The purpose of this study was to determine the effect of yoga on postpartum mothers on the psychological condition of postpartum mothers. Methods:Â Â  The research method used is a quasi-experiment with pre-test and post-test of 22 postpartum mothers. The sampling technique is random sampling. This research was conducted from Juli 2019 â€“ December 2019. The research instrument used to measure postpartum maternal anxiety was the Edinburgh Postnatal Depression Scale (EPDS) questionnaire. Data analysis used paired sample t-test and univariate and bivariate data presentation.Â  Results:Â Â  There is an effect of postnatal yoga on the psychological condition of the mother before and after doing postpartum yoga P value (0.000) < (0.05).Conclusion: There is an effect of postpartum Yoga on postpartum psychological conditions.
HUBUNGAN POLA ASUH ORANG TUA DENGAN PERKEMBANGAN EMOSIONAL ANAK PRASEKOLAH USIA 3-6 TAHUN DI WILAYAH KERJA PUSKESMAS MULYOREJO KOTA SURABAYA
Authors: Fanny Shellya Dwi , Nadhiroh Aim Matun , Taufiqoh Syuhrotut
Published: July 2024

ABSTRACTObjective: Masa anak prasekolah merupakan periode penting dalam perkembangan anak, karena tidak semua anak dapat melalui masa tumbuh kembangnya dengan optimal. World Health Organization (WHO) 2017, melaporkan bahwa 5-25% dari anak usia prasekolah mengalami gangguan perkembangan emosional dengan populasi anak sebesar 23,979,000. Pola asuh orang tua sangat membantu anak dalam mencapai dan melewati pertumbuhan dan perkembangan sesuai tingkatan usianya dengan normal. Penelitian ini bertujuan untuk mengetahui hubungan pola asuh orang tua dengan perkembangan emosional anak prasekolah usia 3-6 tahun di Wilayah Kerja Puskesmas Mulyorejo Kota Surabaya.Methods: Rancangan penelitian berupa analitik korelasional dengan pendekatan Cross Sectional. Penelitian ini dilakukan selama bulan Januari 2023. Populasi penelitian ini sebanyak 125 orang dengan pengambilan sampel menggunakan teknik Quota Sampling dengan jumlah sampel yang diperoleh sebanyak 95 orang tua dan anak. Pengumpulan data dilakukan dengan kuesioner pola asuh yang menggunakan dari Parental Questionnaire (PAQ) dan kuisioner perkembangan emosional anak prasekolah yang menggunakan kuesioner KMPE. Results: Mayoritas ibu menerapkan pola asuh otoriter sebanyak 52 (54,9%) dan mayoritas anak prasekolah memiliki perkembangan emosional yang menyimpang sebanyak 75 (78,9%) anak prasekolah. Data diolah menggunakan uji Rank SpearmanÂ  dengan nilai Ï value = 0,01 sehingga dapat diartikan bahwa signifikan antara pola asuh orang tua dengan perkembangan emosional anak prasekolah. Hal ini membuktikan bahwa ada hubungan antara pola asuh orang tua dengan perkembangan emosional anak prasekolah..Conclusion: Praktik pengasuhan dimasyarkat setiap orang tua dapat menerapkan pola asuh yang berbeda, dengan adanya perbedaan pola asuh tersebut dapat membentuk perkembangan emosional anak yang berbeda-beda
Pemanfaatan Buku Kesehatan Ibu dan Anak (KIA) Dalam Persiapan Persalinan
Authors: Sukarsih Rachmawati Ika
Published: July 2024

Objective: Abstract Breast milk (mother's milk) is the only natural food for babies.  Preparation for childbirth is everything that is understood and prepared in terms of welcoming the birth of a child by pregnant women. Preparation for childbirth is an important part of the delivery process, aimed at improving optimal health before childbirth. Based on 2018 Riskesdas data regarding ownership of KIA books in Indonesia, there are still 24.9% of pregnant women who do not have KIA books. This research aims to determine the use of Maternal and Child Health (KIA) books in preparation for childbirth at the Jagir Surabaya Community Health Center.
Methods: This research is a quantitative research with a descriptive design. In this research, the sample collection technique used purposive sampling with a population of 45 respondents and a sample of 40 respondents. The data collection technique used in this research is primary data in the form of a questionnaire.
Results: The results of the research showed that 40 pregnant women (100%) carried the MCH book during the examination well, 21 pregnant women (52.5%) read the MCH book well, and 30  pregnant women applied the contents of the MCH book well (75%).
Conclusion: The use of the MCH book can be assessed from three aspects, including bringing the MCH book when carrying out examinations, reading the contents of the MCH book, and applying the messages contained in the MCH book, one of which is regarding childbirth preparation.
Analisis Kualitas dan Penerapan Software Quality Assurance pada Web K24klik Menggunakan Model ISO/IEC 9126
Authors: - Rendy Swanda Narastu , Sadarman Zai  , Viktor Handrianus Pranatawijaya  , Widiatry
Published: July 2024

Tujuan dari penelitian ini adalah untuk mengevaluasi penerapan dan analisis kualitas Software Quality Assurance (SQA) pada situs web K24KLIK yang menggunakan Model ISO/IEC 9126, serta untuk mempelajari konsep kualitas perangkat lunak, SQA, dan model ISO/IEC 9126, serta untuk mengumpulkan data melalui observasi langsung, analisis dokumen, dan pengujian langsung situs web. Setelah data dikumpulkan, fitur perangkat lunak seperti fungsionalitas, keandalan, kegunaan, efisiensi, dan portabilitas dinilai. Hasil penelitian menunjukkan bahwa K24KLIK berkinerja baik dalam beberapa hal, tetapi kinerja, pengalaman pengguna, dan keandalan masih perlu ditingkatkan. SQA meningkatkan kualitas perangkat lunak, tetapi membutuhkan pengawasan dan evaluasi terus-menerus dan peningkatan terus-menerus. Jadi, untuk meningkatkan kualitas perangkat lunak K24KLIK, perlu dilakukan perbaikan dan optimalisasi.
Designing modern Russian crushing and transfer units for conveyor ore transportation systems
Authors: Ismagilov R.I. , Zhuravlev A.G. , Furin V.O.
Published: July 2024

The article discusses methodological aspects of designing semi-stationary and mobile crushing and transfer units (DPU) carried out by the experts of Uralmashzavod PJSC and IGD Ural Branch of the Russian Academy of Sciences on behalf of the Russian Metalloinvest company during the development of the Russian DPU-7200 model. As the result of the R&D work performed, a DPU was manufactured and installed at a mining operation as part of the in-pit crushing and conveyor (IPCC) systems, which is intended for conveyor transportation of ore from the open pit. A distinctive feature of the discussed DPU is that it is made as a complete system with the supporting steel structures integrated in its design, which makes it possible to relocate it during the service life when expanding the IPCC. The issues concerned with justifying the DPU layout, parameters of the receiving and unloading hoppers are discussed with account of structural, strength, mining and technological factors. The paper presents the technical characteristics of the developed DPU, as well as the design features of the primary equipment. The impact of the related technological factors, i.e. irregular character of dump truck traffic, the technological and temporal modes of the IPCC operation in general and those of the DPU in particular, the designed schedule of maintenance and repair, etc., is shown.
Designing a digital model of a coal deposit in the MINEFRAME mining and geological information system
Authors: Anistratov K.Y. , Nagovitsyn O.V. , Nagovitsyn G.O. , Vasileva M.O.
Published: July 2024

Digitalization of enterprise management using Russian software is the main trend in the development of the country's mining sector. Sharp fluctuations in demand and prices in the mineral markets, as well as the development of technical tools for mechanization and automation of technological processes along with a systematic increase in their cost affect the financial performance of mining companies. This determines the need for a rapid adoption of technical, technological and organizational decisions, which, along with the requirements of the company's owners and regulators to obtain prompt, reliable and the most complete information about the production process explains the urgent need for the prompt introduction of digital control systems for mining operations. In the article the authors describe an algorithm to design a digital model of the mining and geological system, including a digital geological model of the deposit, digital models of mine workings and the surface topography, based on the experience of creating three-dimensional digital models of complex-structured coal deposits. The basic software suite for designing a digital management system for mining operations is the MINEFRAME mining and geological information system developed at the Mining Institute of the Kola Scientific Center of the Russian Academy of Sciences. MINEFRAME allows to perform a full range of tasks aimed at creation of a digital 3D model of the mining and geological system for a coal deposit with the possibility to account for the complex bedding in the modelling. High accuracy and correctness of the input geological sampling data is achieved by means of tools to check for errors in the tables of borehole collar coordinates, inclinometry and sampling. The wireframe modelling methods implemented in MINEFRAME provide the possibility to create wireframe models of seams with high detail in the fracture zones.
Astronomy, Ṭupšarrūtu, and Knowledge in the Cuneiform World
Authors: Rochberg Francesca
Published: July 2024

This paper aims to critique a historiography of science that sees Greek science as exemplary. It discusses the entry of Babylonian astronomy into the history of science and defines the cuneiform scribal-scholarly knowledge termed ṭupšarrūtu as a basis for understanding the scope and character of cuneiform science without comparison to Greek or later sciences.