bluuebunny/crossref_metadata_2025 huggingface dataset:
Adverse Drug Events on the Use of Sertraline in Clinical Studies: A Review
Authors: Hidayat Syahrul , Puspitasari Irma M.
Published: March 2022

Major depressive disorder (MDD) and anxiety are known as a widespread public health problem treated with sertraline, a class of Selective Serotonin Reuptake Inhibitor (SSRI) drugs as first-line therapy. However, clinical evidence showed that MDD and anxiety therapy with sertraline has not been optimal due to patient non-compliance associated with adverse drug events (ADE) occurring. A literature search on sertraline clinical study was conducted on the PubMed and Science Direct electronic database in April 2020. A total of 12 articles from 5.664 articles have been selected at the initial screening. A total of 6 articles used sertraline as a testing drug in MDD patients, 2 articles used sertraline as testing drug in anxiety patients, 2 articles with sertraline as a comparative drug, 1 article with sertraline as a positive control, and 1 article with sertraline as an adjuvant in MDD patients. Studies on these articles were carried out worldwide from 2010 to 2019. ADEs that occur due to the use of sertraline were: gastrointestinal disorders, nutritional and metabolic disorders, central nervous system disorders, sweating, sleep disorders, irritability, eye disorders, as well as disorders of the skin and subcutaneous tissues. Nausea is the most common ADE of sertraline. ADEs are affected by several factors such as, age, the sertraline combination therapy, and alcohol consumption.
Faktor yang Berhubungan dengan Tingkat Pengetahuan Masyarakat dalam Mengelola Obat Sisa, Obat Rusak dan Obat Kedaluarsa
Authors: Pramestutie Hananditia Rachma , Lllahi Ratna Kurnia , Hariadini Ayuk Lawuningtyas , Ebtavanny Tamara Gusti , Aprilia Tia Eka
Published: March 2022

Problems that often arose as a result of improper management of unused, damaged, and expired drugs in storage and disposal, include drug abused, increased environmental damage, antibiotic resistance, and decrease effectiveness of therapy; due to the lack of public knowledge that can caused by several factors. This study aims to analyse factor associated with level knowledge in the management of unused, damaged, and expired drugs in Malang Raya. This study was an observational analytic study with a cross-sectional design. The subjects were the people of Malang Raya who were selected using a convenience sampling technique in accordance with the inclusion and exclusion criteria. The subjects were 322 respondents. The instrument used was a questionnaire to measure the level of knowledge of respondents that had been tested for validity and reliability. The results showed that, level of knowledge of respondence at Malang Raya in the management of unused, damage and expired drugs in the good (21%), sufficient (58%), and less (21%). Statistical tests used in this study were Somers'd, Kruskal-wallis, and Lambda tests to analysed factor associated with subjects’ level of knowledge in the management of unused, damaged, and expired drugs. There were a significant relationship in factors included age (p = 0.018) and income level (p = 0.003). It can be concluded that among the factors associated with  the level of knowledge in the management of unused, damaged, and expired drugs, only age and income level were statistically significant. Further study is needed to determine the factors affecting the level of knowledge the most.
Pengembangan Kuisioner Udayana untuk Penilaian Kepuasan Pasien terhadap Pelayanan Kefarmasian oleh Apoteker di Pusat Kesehatan Masyarakat
Authors: Larasanty Luh Putu Febryana , Jaya Made Krisna Adi , Astuti Ketut Widyani , Santika I Wayan Martadi
Published: March 2022

The implementation of pharmaceutical care by pharmacists at the community health center has been regulated in the Minister of Health Regulation No. 74 of 2016. Based on that regulation, assessment of pharmaceutical care services is needed to ensure the quality of services provided by pharmacists. This study aims to develop an Udayana questionnaire that can be used to evaluate the quality of pharmaceutical care provided by pharmacists at community health centers. This research is quantitative (survey implementation) carried out in 2 phases. The first phase is the design of the Udayana questionnaire. The second phase is to verify the validity and reliability of the questionnaire. The questionnaire validity test was carried out in three stages, namely the logical validity test, content validity, and construct validity. The questionnaire statement develop based on Minister of Health Regulation No. 74 of 2016 obtained 31 statements which are divided into 5 dimensions of service quality. The logical validity test resulted in 30 statements that were declared valid by experts. Content validity test is done by calculating the value of the content validity ratio (CVR) and the value of the content validity index (CVI). The CVR and CVI results showed that 7 statements were eliminated because they were not valid (CVR value <0.99 and CVI <70%). Construct validity test and questionnaire reliability were tested on 384 respondents who had met the inclusion criteria. The construct validity test resulted 23 valid statement (r = 0.148). Results of the reliability test based on Cronbach's Alpha value is greater than 0.6, indicating that all the valid statement items in the Udayana questionnaire are reliable. Based on the results of validity and reliability tests, 23 statements of Udayana's questionnaire are stated valid and reliable and can be used to evaluate the quality of pharmaceutical care at the community health center.
A Scoping Review of Disposal of Unused Medicines in Take-Back Programs
Authors: Rahmadani Mufti Alifia , Kristina Susi Ari
Published: March 2022

Unused medicines in the household cause many problems. Medicines take-back programs were established to prevent inappropriate medicines disposal, abuse, accidental poisoning, and help reduce the number of unused medicines in households. A literature search using the keywords “unused AND medicine”, “disposal AND unused AND medicine”, “reasons AND medicine AND disposal”, “medicine AND take-back program” and “cost AND medicine AND take-back program” in PubMed, Science Direct, Scopus and Google Scholar. Articles published in 2010 – 2020 in English report the medicine take-back program with the number of medicines and/or reasons for the return and/or economic value of medicines collected in the medicines take-back program. A total of 16 articles were included in the criteria for this systematic review. Medicines take-back program was majority-owned in the US (69%). Two programs focus on returning controlled medicines. Gastrointestinal, respiratory, cardiovascular, antimicrobial and non-narcotic analgesic were the most common of all medicines returned. The expired medicine and treatment discontinuation by (doctors/prescribers) were the most reason medicine was returned to the medicines take-back program. The total cost of all medicines returned topped $1,118,020. Medicines take-back program was an essential solution to the inappropriate medicine disposal problem. Good coordination was required between the government and other authorities.This medicine take-back issues can help solve the problems of medicine use, storage, and disposal that lead to the country's economy.
Evaluasi Pengelolaan Obat dan Bahan Medis Habis Pakai di Puskesmas Kota Kupang serta Strategi Pengembangannya
Authors: Lutsina Novi Winda , Lette Arman Rifat
Published: March 2022

The management of drugs and disposable medical supplies in healthcare units greatly affects the quality of healthcare services. However, the management is still not carried out optimally because it is not up to the standard. The Hanlon method is a basic priority rating system (Brief Priority Rating Scale, BPRS) which is used to compare health problems with relative and objective to identify factors that must be considered in determining a priority. This study aimed to describe and measure the efficiency of drugs and disposable medical supplies management in Healthcare Centers in Kupang City by using efficiency indicators and to develop the strategy using the Hanlon method. The design of this research is a descriptive quantitative-qualitative combination using retrospective and concurrent data. The sampling technique used was a total sampling of 11 Healthcare Centers in Kupang City, while the object of the study was the management of drugs and disposable medical supplies which were assessed using efficiency indicators. The results of research on the management of medicines and consumable medical materials at 11 Healthcare Centers in Kupang City have not been carried out efficiently because not all indicator values reached the standard, namely the suitability of drug items with DOEN and FORNAS, conformity of items received, the accuracy of planning, items expired or damaged, items that were not prescribed for 3 months, the level of availability of the drug, the percentage of drugs with generic names, use of antibiotics in patients with non-specific diarrhea and the average item per prescription sheet. Therefore it can be concluded that the management of drugs and disposable medical supplies in 11 Healthcare Centers in Kupang City using indicators at the selection, procurement, distribution, and use stages are not yet according to standards and the proposed improvements are proposed as a management development strategy, namely optimizing planning according to the needs of the health center, monitoring stock. and expiration date and conduct regular learning and growth of all human resources.
Pengaruh Medication Therapy Management terhadap Persepsi Sakit dan Outcome Klinik Pasien Diabetes Melitus di Puskesmas Kota Yogyakarta
Authors: Yasin Nanang Munif , Andayani Tri Murti , Listyana Yanverty Idda
Published: March 2022

Diabetes Melitus (DM) merupakan penyakit kronis yang komplek membutuhkan perawatan medis berkelanjutan dengan strategi pengurangan risiko multifaktorial di luar kendali glikemik. Penyakit DM memerlukan managemen terapi yang tepat, salah satu upaya yang diberikan adalah Medication Therapy Management (MTM). Pasien yang mendapatkan MTM memiliki persepsi sakit terhadap penyakitnya menjadi lebih baik dan akan berpengaruh pada hasil terapi. Penelitian ini bertujuan untuk mengetahui pengaruh pelayanan farmasi berbasis MTM terhadap persepsi sakit dan outcome klinik pada pasien diabetes melitus di Puskesmas Kota Yogyakarta pada periode Maret-April 2020. Jenis penelitian yang digunakan adalah quasi experimental one group with pretest and posttest design. Analisa menggunakan uji paired sample t-test dengan signifikansi yang digunakan P<0,05. Responden berjumlah 20 orang, merupakan pasien diabetes melitus tipe 2 yang memenuhi kriteria inklusi dan mendapatkan pelayanan farmasi berbasis MTM oleh apoteker berupa asesmen, edukasi, dan konseling. Hasil penelitian diperoleh skor persepsi sakit pasien terhadap penyakitnya yang diukur menggunalan brief illness perception questionnaire (BPI-Q), sebelum mendapatkan pelayanan MTM 49,95±10,41 menjadi 50,45± 10,06 (P=0.780). Outcome klinik berupa kadar glukosa darah puasa semula 128,66±43,99 mg/dL menjadi 129,96±23,46 mg/dL (P=0,876) setelah mendapatkan pelayanan berbasis MTM. MTM pada penelitian ini bisa meningkatkan skor persepsi sakit pasien terhadap penyakitnya meskipun belum berbeda bermakna, sedangkan hasil pemeriksaan kadar glukosa darah puasa pasien belum memberikan perbaikan outcome klinik pasien. Diperlukan penelitian dengan periode waktu yang lebih lama dan jumlah responden yang lebih banyak.
Adaptation and Validation of the Beliefs about Medicines Questionnaire (BMQ) in HIV Out-patients in Indonesia
Authors: Sianturi Elfride Irawati , Gunawan Elsye , Perwitasari Dyah A.
Published: March 2022

This study aimed to translate and cross-cultural adapt the version of the Beliefs about Medicines Questionnaire (BMQ) into Indonesia language, and explored its psychometric properties, and establish preliminary norms. We followed the guideline for forward-backward translation and 201 HIV out-patients were recruited. They all completed BMQ-general and BMQ-specific scales that were previously culturally adapted and translated into the Indonesian language. All participants were patients visiting a referral hospital in Papua Province, Indonesia. One-third of participants were indigenous Papuans, and the majority were female. The overall Cronbach's alpha of BMQ was acceptable (0.80) however each domain of BMQ was lower than the original study. The Cronbach alpha value for each section of BMQ-Indonesian version was as follows: BMQ Specific-Necessity 0.56; BMQ Specific-Concerns 0.50; BMQ General-Overuse 0.65; and BMQ General-Harm 0.53. The reasons for the distinction between this study to original may be complex and HIV associates with the problem in neurological and cognitive symptoms at a later stage. Since the Cronbach alpha in this study was within the range of the original study the BMQ-Indonesian version is applicable to be used in Indonesia, especially among HIV patients but caution is still needed in this questionnaire.
Pemanfaatan Geospasial Melalui Health and Demographic Surveillance System (HDSS) pada Pasien Tuberkulosis dalam Manajemen Obat
Authors: Puspandari Diah Ayu , Setiyaningsih Hermawati , Atsna Zafria , Andayani Tri Murti
Published: March 2022

Tuberculosis (TB) is an infectious disease that causes a high mortality rate. Currently, Indonesia is the largest contributor to TB cases in the world. In 2019, the estimated number of cases was 845,000 cases, while case enrollment was 562,000. Thus, the Gap in the Case finding is high. As a result, innovation is needed in setting strategies to develop Regulations related to the national TB program, one of which is geospatial. This study aimed to provide an overview of geospatial utilization through HDSS in tuberculosis patients about drug management. Geospatial is an epidemiological approach that can be used to determine policies in accordance with conditions in an area. The research type is a quantitative study using secondary data from the Health and Demography Surveillance System (HDSS) of Sleman in 2016 and the Integrated TB Information System (SITT) of Sleman Regency in 2016. The analysis used descriptive analysis and geospatial mapping used Stata 15 and R software. Geospatial data shows that TB cases are concentrated in densely populated areas, such as Depok, Mlati, Ngaglik, and Gamping sub-districts. In addition, geospatial shows us the distance between the distribution of cases and the availability of health service facilities (puskesmas). The spread of cases is mostly found in the area around the health facilities, and low cases are in areas far from the health facilities. This condition possibly happens because case tracking is less affordable. Knowing the number and distribution of TB cases and the distribution of health care facilities can be used as a basis in the policy-making process, planning of the need for TB drugs, drug distribution, and priority interventions for TB services in a cost-efficiency.
Screening and Prediction of Potential Compounds from Virgin Olive Oil Acting on Proteins Associated with Cancer Disease
Authors: Rodiansyah Achmad
Published: March 2022

Virgin olive oil contains phenolic compounds that were potential for anti-inflammatory and cancer treatment. Computational biology is a beneficial method to understand how this compound can affect the biological process in humans. This research is conducted by the potential screening of VOO compounds, constructing the pharmacological network and enrichment, and docking simulation. The enrichment result showed that the EGFR, BRAF, MAPK1, CCND1, and MDM2 protein have multiple cancer contributions and related pathways. The docking simulation result showed that the interaction of EGFR-luteolin, BRAF-luteolin, MAPK1-luteolin, CCND1-apigenin, and MDM2-1-hydroxypinoresinol has the highest binding affinity. Further research with the in-vitro method is required to check the reliable mechanisms of each compound to their protein target.
Formulation and Evaluation of Water Fraction Hair tonic Containing Flavonoids from Ethanolic Extract of Green Tea Leaves (Camellia sinensis L.)
Authors: Apriani Elsa Fitria , Ahmadi Adik , Noviani Vini
Published: March 2022

Hair growth tonics containing herbal and synthetic ingredients have been developed to overcome hair loss and baldness. Advanced technological developments made many Indonesians prefer to use herbal products compared to synthetic products due to their fewer side effects. Green tea leaves (Camellia sinensis L.) is a plant believed to increase hair growth rates due to its flavonoid compounds. The purpose of this study is to formulate hair tonic from water fraction ethanolic extract green tea leaves, to look at the activity of hair growth-promoting, and also to look at physical stability, irritation tests, and microbial contamination.  The positive control used is 2% Minoxidil. The hair growth activity test was carried out by applying a hair tonic to rabbits. Hair growth measurement data were statistically tested by the ANOVA test. The formulated green tea leaves tonic met the physical properties test. The tonic produces similar growth activities with the positive control (significance difference (p> 0.05)). In addition, the tonic does not have a skin irritation effect on rabbit skin and is free from bacteria.
Antioxidant and Anticancer Potential of Raja Bulu Banana Peel and Heart (Musa acuminata Colla (AAB group)) Ethanol Extracts in MCF-7 Cell Lines
Authors: Sutjiatmo Afifah Bambang , Widowati Wahyu , Sumiati Ida , Priestu Twice , Arumwardana Seila , Kusuma Hanna Sari Widya , Azizah Alya Mardhotillah
Published: March 2022

Breast cancer is an uncontrolled cell growth in breast tissue. Surgical treatments of breast cancer can reduce breast aesthetics and chemotherapy can cause severe side effects. It makes the searches for plants as breast anticancer agents intensively carried out. Several studies have shown that banana peels and hearts possess antioxidant and anticancer activity. This study aims to determine the fruit peel and heart of Raja Bulu banana (Musa acuminata Colla (AAB group)), an endemic banana species in Indonesia, potential as antioxidant and anticancer agent in MCF-7 cells. Antioxidant potential was determined by using 2,2-diphenyl-1picrylhydrazyl (DPPH) and hydrogen peroxide (H2O2) scavenging activity assay. Anticancer potential was determined by cytotoxic test using MTS (3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium). The results showed that 70% ethanol extract of fruit peel (PBEE) and heart (HBEE) of Raja Bulu banana had median inhibition concentration (IC50) for DPPH scavenging activity at 115.32 µg/mL and 162.52 µg/mL respectively, while for H2O2 scavenging activity at 624.80 µg/mL and 497.13 µg/mL respectively. Anticancer potential was expressed by inhibiting concentration of 50% proliferation (IC50) of MCF-7 cells for PBEE and HBEE were 115.001 µg/mL and 338.469 µg/mL respectively. This study showed that PBEE and HBEE have antioxidant and anticancer.
Antitussive Activity of Herbal Cough Medicine on Guinea Pigs (Cavia porvellus)
Authors: Ikawati Zullies , Arifin Poppy Firzani , Sandy Severinus Nugraha Krisma , Susilowidodo Raphael Aswin , Wisastra Rosalina
Published: March 2022

This study aims to investigate the antitussive activity of herbal cough medicine containing combined herbal extracts of Echinacea purpurea, Sambucus nigra (Black Elderberry), Glycyrrhiza glabra (licorice), Vitex trifolia (Indian wild pepper), and Zingiber officinale (ginger). Antitussive assays were conducted on male Dunkin-Hartley albino guinea pigs (Cavia cobaya), which are divided into 5 groups, each with 8 individuals. These 5 groups were assigned for negative control group (treated with CMC-Na 0.5%), a positive control group (treated with Dextromethorphan 20 mg/kg BW), and three groups receiving herbal medicine with 3 different doses (Group I: 145 mg/kg BW, Group II: 290 mg/kg BW; Group III:  580 mg/kg BW, respectively). The antitussive activity was evaluated by using a citric acid-induced cough assay. For baseline level, 20 % m/v liquid citric acid was exposed using a nebulizer for 10 min, then the number of coughs in 15 min was counted.  Sixty (60) minutes after oral administration of the tested herbal cough medicine, the number of citric acid-induced coughs was counted again to see the effect of herbal cough medicine to reduce cough. The number of coughs before and after herbal administration was calculated to obtain antitussive activity, represented by the percentage of cough suppression (PCS). Average PCS for each treatment group is then compared to control positive Dextromethorphan 20 mg/kg BW and control negative CMC-Na 0.5%. Data are analyzed by applying the one-way ANOVA method, which is followed by conducting a Tukey’s Test to discover differences between groups at 95% level of confidence. In terms of the percentage of cough suppression (PCS), treatment doses at 145mg/kg BW, 290 mg/kg BW and 580 mg/kg BW result in 58.48% ± 8.60% (Group I); 58.69% ± 7.96% (Group II); 59.21% ± 8.79% (Group III) PCS, respectively, which insignificantly differ to treatment with Dextromethorphan dose (66.99% ± 9.63 with p > 0.05, implicating that the herbal cough medicine has comparable effect with dextromethorphan in the doses used in this study.
In Vitro ACE Inhibitory Activity and Bioactive Compounds of Aqueous Extract of Citrus amblycarpa
Authors: Kusumawati I Gusti Ayu Wita , Putra I Made Wisnu Adhi , Yogeswara Ida Bagus Agung
Published: March 2022

Citrus amblycarpa contain flavonoid-rich compounds and play important role in suppressing the conversion of angiotensin-converting enzyme 1 (ACE 1) to angiotensin-enzyme 2 (ACE 2). This study aimed to determine the bioactive compounds in the lime peel extract and their ability as in vitro ACE inhibitor activity. The lime peel extract was obtained by boiling the dried peel and dried leaves for 7 min at 70oC. The bioactive compound of the peel and the leaves were compared. The total phenolic, quercetin, rutin, and GABA were further quantified using spectrophotometer UV vis. The aqueous extract of C. ambylcarpa peel showed a high concentration of phenolic, quercetin, rutin, and GABA than that of the leaves extract. Furthermore, the peel extract at low concentration (0.0001 g/mL) has high efficiency in inhibiting ACE activity up to 133%. It can be concluded that the peel of C. amblycarpa is a good candidate for the management of hypertension.
Application of Ozonated Olive Oil as Adjunctive Therapy after Periodontal Pocket Curettage towards Collagen Density of Alveolar Bone in Periodontitis Healing Process (In Vivo Study with Sprague dawley)
Authors: Herawati Dahlia , Pertiwi Etty Cahya
Published: March 2022

Periodontitis is an inflammatory disease of the supporting tissue of the teeth caused by specific microorganisms or groups of specific microorganisms, resulting in progressive destruction of the periodontal ligament and alveolar bone with periodontal pocket formation. Application of ozonated olive oil in dentistry is based on the actions such as antimicrobial and therapeutic agent, needed as adjunctive therapy after periodontal pocket curretage. Collagen is the main constituent of alveolar bone extracellular matrix and needed as a scaffold in the formation of mineralized matrix. The aim of this study was to determine the density of collagen in alveolar bone on periodontitis healing process after adjunctive topical application of ozonated olive oil in periodontal pocket curretage. In this study, 32 Sprague dawley rats were randomly divided into two groups: curetted-topical application of ozonated olive oil as treatment groups and curetted-topical application of 1% CMC-Na as placebo group. Periodontitis induced by placing silk-ligature around submandibular incisors for 7 days. Subsequently, the rats were sacrificed on days 3, 5, 7, and 14 after curetted and topical application, and each group was represented by four rats. The staining was done using Mallory staining method. All the results were statistically analyzed using Kruskal-Wallis and Mann-Whitney tests. The results showed that there were significant differences (p<0,05) in the density of collagen between two groups. The study concluded that adjunctive topical application of ozonated olive oil after periodontal pocket curretage significantly increase the density of collagen in alveolar bone on periodontitis healing process in Spraque dawley.
The Extract of Purple Sweet Potato Against Heat-Shock Protein 70 Expression in White Male Rat of Atherosclerosis Model
Authors: Setiawan Meddy , Yulanda Fitriana
Published: March 2022

Shock protein 70 (Hsp-70) molecule is pro-inflammatory mediator cytokine that trigger atherosclerosis. The purple sweet potato has many natural antioxidants such as flavonoids (anthocyanins) and is valuable for reducing Hsp-70 expression due to its antioxidant content.This study aims to determine the effect of purple sweet potato (Ipoema batatas L.) extract in reducing the Hsp-70 levels in the white male rat atherosclerosis model.This study was a posttest-only control group design with normality, homogeneity, ANOVA, post hoc test, correlation, and regression tests. There were five groups in this study. Groups 1 (negative control) and 2 (positive control) were given 2 ml/day of high-cholesterol diet for eight weeks, and the other three groups were given purple sweet potato extract at 24, 48, and 96 mg/kg doses weight per day for eight weeks. Results: The purple sweet potato extract affected the Hsp-70 levels in Wistar strain rats (p < 0.05). There was a significant difference in the Hsp-70 level between the positive control group and the group with purple sweet potato extract. The highest Hsp-70 level reduction was seen in the group with a 96 mg/day dose of purple sweet potato extract. In conclusion, theadministration of purple sweet potato extract (I. batatas L.) reduced the Hsp-70 levels. The dose of 96 mg/kg BW/day had the highest effect on decreasing Hsp-70 levels in the male rat atherosclerosis model.
Supplementation of Garcinia mangostana Linn and Vasconcellea pubescens A.DC extract reduced exercise-induced oxidative stress in rats
Authors: Sasongko Heru , Sugiyarto Sugiyarto , Hidayati Renita Wahyu Nur , Saputro Bayu Anggoro
Published: March 2022

The objective of this study was to see how supplementation with Garcinia mangostana extract (GME) and Vasconcellea pubescens extract (VPE) affected exercise performance and oxidative stress in intensely exercised rats. Twenty-five male rats were used in the study. Rats were divided into five groups: normal, stress oxidative control, combination GME:VPE (50:50), combination GME:VPE (75:25), and combination GME:VPE (25:75) groups. The antioxidant activity of a single extract from the literature was used to make the percentage comparison between extracts. The chronic exercise was done by swimming at 10 m/day for two weeks. Rats in the acute exercise groups were treated by swimming on the pail containing water. Blood samples were collected from the orbital sinus to determine hematological parameters. Liver tissue samples for the analysis of malondialdehyde (MDA) and glutathione (GPx)  markers. Data analysis was performed statistically using One Way ANOVA. The combination of GME and VPE was shown to be effective in reducing oxidative stress and increasing MDA and GPx enzyme activity. The administration of both extracts also showed changes in the hematological profile.
THE DEVELOPMENT OF BYZANTINE STUDIES AT THE UNIVERSITY OF NIŠ
Authors: Šaranac Stamenkovic Jasmina
Published: March 2022

The development of the Byzantine Studies at the Faculty of Philosophy of the University in Niš is presented chronologically, starting from the establishment of the Department of History in 1998. The professors from the Department of History (Seminar for Byzantine Studies) at the Faculty of Philosophy in Belgrade and from the Institute for Byzantine Studies of the SASA (Serbian Academy of Sciences and Arts) had the key role in the development. Scientific cooperation was also established with these two most prominent institutions in the state. The product of such cooperation was the increased interest in the Byzantine studies at the University of Niš.
PROFESSIONAL TRAINING AND DEVELOPMENT OF EMPLOYEES IN THE PUBLIC SECTOR – LEGAL ASSUMPTIONS
Authors: Ilić Mile , Ilić Petković Aleksandra
Published: March 2022

In the Republic of Serbia, many areas are undergoing reform processes that should bring our country closer to the European Union. This incorporates various activities aimed at achieving this goal. In the public sector, especially in the state administration, local self-government, and public services (primarily educational institutions), there are legal solutions which are considerably harmonized with the practice and legal system of similar European countries. Such is the case with the professional training and development of employees in the state administration, local self-government and public services (especially educational institutions). The necessity for employees' continuing activities in these areas is noticed, not only in terms of professional training, but especially in terms of their own professional development. Employees themselves can deal with that, but it is also the obligation of the institutions in which they work. This is particularly important for public sector employees - in state administration, local self-government and public services. The paper provides a legal framework for professional training and development of employees in the state administration, local self-government and public services, especially in the institutions in the field of education, and suggests some ideas for the improvement of particular legal solutions.
CREATIVE GAMES WITH DIFFERENT MATERIALS IN ARTS EDUCATION
Authors: Stojanović Stošić Milena , Stajić Jovana
Published: March 2022

The paper analyzes teachers’ attitudes and beliefs concerning the use of different materials that can be used for artistic expression in arts education called non-standard art material (NAM)[1]. By manipulating and experimenting with these materials children participate in creative games that incite curiosity, initiate first original ideas and strengthen the team spirit. The research was conducted on a sample of 56 teachers who work in primary schools in the territory of the town of Vranje. The instrument used to collect the data was constructed for the purpose of this research. The results indicate the importance of the use of NAM in arts education – their application in the realization of a great number of units since the first grade of primary school develops creative and critical thinking among pupils, which further contributes to a more creative approach to teaching other subjects.[1]A vast array of semi-shaped, refuse material for recycling, natural material that has found its application in arts education
Order Prioritization Prediction System for Sample Rooms in the Garment Industry
Authors: Silva Shirendra De , Ratnayake Gayashini Shyanka
Published: March 2022

Abstract: In the garment industry, one of the most prevalent industries in Sri Lanka, the process of sampling is key to gaining a competitive advantage in the market. The sample rooms in garment factories are considered the most important section in the readymade garments industry. Numerous processes occur in sample rooms, from perfecting patterns and quality checks on certain fabrics to confirming bulk production orders for prospective customers. Therefore, for these vital processes that occur in the sample room to function as efficiently as possible, they require the most accurate data. Research, including an initial pilot study done on a small to medium garment factory, suggests that approximately 35% of sample rooms in garment factories under utilise their capacity in accordance with demand. One reason being that most garment factories are based in developing countries, where the production focus is more labour intensive and less technology intensive. Not being able to accurately worker productivity metrics, coupled with a low merchandiser visibility on sample progression, would not allow the sample room to work on numerous pre-designs prior to the order. This hinders the chance for example, for designers to take on more simultaneous projects and approve bulk productions faster, resulting in potential losses for the organisation (Windmuller, 2020). Keywords: SMV: - Known as Standard Minute Value, it is the value of the calculated accepted time to finish a particular garment job is known as the Standard Minute Value.
Indian Railway Tweet Monitoring System
Authors: Aware Sanyam
Published: March 2022

Abstract: In today’s fast paced and competitive world, India is home to one of the world’s largest railway networks. According to statistical facts, approximately 22 million passengers travel via trains every day. A majority of them are on various social networking site including Twitter, adding to this, more than 200 million users are active daily on this application, tweeting more than 500 million tweets every day, out of them, at least 600 are based on the sole topic of complaining about railways, about 5% are suggestions and etc. To help out the Indian Railway Ministry to quickly classify and/or clarify the tweets as soon as possible and in a much more efficient manner, we would provide a solution by helping them classify the types of posts such as if it is a complaint, or just feedback, or some other type. Since almost everyone on this planet wishes to get a swift and quick response for any query they have, this application would allow the whole team behind the scenes to efficiently handle all the tweets, give a response to the posts, and allows them enough time to get working on an issue.
APLIKASI PEMESANAN PAKET PRASMANAN CAFE BEACH UTAMA RAYA BERBASIS WEB
Authors: Nofiana Nofiana , Syafiih M. , Arifin Zainal
Published: March 2022

Cafe Beach Utama Raya merupakan cafe yang sangat banyak diminati pengunjung. Hal ini dikarenakan Utama Raya memiliki view pantai yang indah serta makanan dan minuman yang lengkap dan menyediakan paket prasmanan untuk acara ulang tahun, meeting, pernikahan atau acara lainnya. Pemesanan paket prasmanan di Cafe Beach masih dilakukan dengan media chat (Whattsap), atau memesan langsung dengan mendatangi Café Beach Utama Raya. Berdasarkan banyaknya menu tersebut sering terjadi permasalahan pada saat costumer melakukan pemesanan paket, maka petugas mengirimkan satu persatu foto-foto menu paket beserta foto atau video lokasi yang tersedia, dengan banyaknya paket prasmanan yang tersedia di Café beach Utama Raya mengakibatkan sering terjadi kesalahan saat mengirimkan menu paket prasmanan sehingga terjadi komplen dari costumer, dari kesalahan tersebut berimbas kepada perhitungan atau pembayaran. Model pengembangan sistem yang akan digunakan penelitian yaitu model prototype. Berdasarkan pembahasan yang sudah dilakukan, pertama telah dibuat aplikasi pemesanan paket prasmanan café beach utama raya yang memiliki responden baik dari supervisor café beach sendiri dan costumer. Untuk hasil pengujian pada supervisor dan costumer menghasilkan nilai responden tertinggi 96% memilih sangat baik pada pertanyaan 1,2 dan 4 sedangkan 92% menyatakan sangat baik untuk pertanyaan 3 dan Sehingga aplikasi pemesanan paket prasmanan café beach utama raya sangat baik digunakan dan dikembangkan lebih lanjut.
Model Prediksi Data Besar Distribusi Produk Farmasi: Analisis Kinerja Model Deep Learning
Authors: Fadli Faisal , Suwilo Saib , Zarlis Muhammad
Published: March 2022

Seiring dengan berjalannya bisnis perusahaan, masalah dalam penyimpanan dan pengolahan data besar pun akan semakin kompleks. data yang tidak terorganisir dapat menyebabkan perusahaan gagal dalam memaksimalkan strategi penjualan. Salah satu pendekatan untuk memaksimalkan strategi penjualan tersebut adalah dengan peramalan.penelitian ini bertujuan  untuk mengurangi tingkat persediaan pelanggan jangka pendek dan membantu dalam menentukan target penjualan yang realistis di masa depan dengan mengusulkan metode pembelajaran mendalam berdasarkan segmentasi pelanggan. Kerangka analisa diusulkan menggunakan teknik Robust Principal Component Analysis (RPCA) untuk mengurangi dimensi kumpulan dataset, kemudian algoritma K-Means Clustering diterapkan untuk mengidentifikasi kelompok populasi guna melihat beberapa kluster yang dapat sangat mewakili karakteristik basis pelanggan perusahaan yang ada. Terakhir lapisan CNN dan LSTM digabungkan untuk memperkirakan penjualan masa depan. Hasil peramalan dievaluasi menggunakan Mean Absolute Error (MAE) dan Root Mean Square Error (RMSE). Pendekatan yang diusulkan guna mengisi celah masalah yang terjadi karena kurangnya informasi mengenai kurangnya informasi tentang kinerja bisnis dalam hal kategorisasi produk.
On the way to autonomous navigation
Authors: Volodin Alexey B. , Presnov Sergey V. , Yakunchikov Vladimir V.
Published: March 2022

The national aspects of readiness and the tasks of introducing autonomous (unmanned) navigation in the near future are considered. The purpose of the study - identification of economic benefits and risks, problem areas of implementation of autonomous navigation technologies. The economic benefit is based on a reduction in the costs of paying the crew of the ship, living on board it, reducing losses from accidents. If the question what? has already been answered - the installation of autonomous navigation systems is available for naval vessels today, then the question why? has not yet been resolved. If the main benefit is expected from a reduction in crew, then a noticeable reduction in crew is possible only for newly built and relatively modern vessels with an auto- mation level of at least AUT2, the share of which under the flag of the Russian Navy is about 15%. At the same time, the modernization of existing inland navigation vessels into autonomous vessels is now available for less than 2% of the river transport fleet (vessels with an automation level of A1), which suggests that autonomous inland water transport only has to be built. The risks also include the slow pace of construction of new ships, as well as retraining and further employment with a massive reduction in the crew of ships. Foreign and domestic experience of the initial stage of autonomous navigation implementation is considered.
General planetary vehicle and industrial space necklace “Orbit” as an alternative to rocket near space exploration
Authors: Unitsky Anatoli E. , Pronkevich Sergei A. , Artyushevsky Sergei V. , Looksha Vitali V.
Published: March 2022

The paper presents an alternative to rockets general planetary vehicle (GPV) and industrial space necklace Orbit (ISN Orbit), which are a single complex necessary for the non-rocket near space exploration. The authors analyzed the conceptual design of the GPV and ISN Orbit, described their main characteristics, compared the impact of the GPV and launch vehicles on the Earthэs ecology. The principle of the GPV movement is based on centrifugal forces arising from the GPV acceleration in the plane of the equator. This is the main difference from rocket engines, which principle of operation is set up on the use of jet motion. The differentiation in the operation principles of the GPV and launch vehicles leads to serious variety in the energy required to lift the GPV to the near-Earth orbit and, accordingly, the variety in cost per payload ton. The concept of the ISN Orbit is described. The complex should serve as a basis for the removal of harmful industry to the near-Earth orbit and become a launching pad for active expansion into space. The GPV and ISN Orbit are effective means for the complex and progressive solution of environmental problems on Earth and productive implementation of space direction.
Russian Language Classes through Thematic Learning “About the Country, about the Homeland, about the Human”: Metasubject Aspect
Authors: Nikolaenko Sergey Vladimirovich
Published: March 2022

In the educational process of acquiring or learning languages, humanitarian knowledge and related skills (both academic and extracurricular, also termed as hard and soft skills) are responsible for not only a native speakers cognitive activity, but also for their behavioral scenarios. This statement ensures the relevance of this research. The objective of the article is to determine methodological recommendations that can be used in Russian language classes at educational institutions of the Republic of Belarus which aim at preserving regional / national places and images of memory presented in fiction and journalistic texts. The material that is used in class comprises texts created by Marc Chagall, Robert Rozhdestvensky, David Simanovich that aim at educating the generational trajectory by means of the language.
The Spiritual Elevation Expressed by Hidden Narrative Processes in Dostoevsky’s Novel “The Eternal Husband”
Authors: Biange Zhang , Xiaoshun Ren
Published: March 2022

In Dostoevsky’s novel “The Eternal Husband”, the theme of spiritual elevation is conveyed by two implicit narrative processes developing in parallel with the explicit plot, based on the theme of revenge. Each of the two implicit narrative trajectories reveals the complex vertical spiritual growth of the victimized lover and the victim husband, respectively, which becomes a strategy for expressing the author’s intent. The three parallel narrative trajectories together reveal the multilayered themes of the story and the multilayered connotations of the text. Many vague places and “superfluous” details become clear and necessary with the introduction of hidden narrative passages that reveal the themes of fall and salvation.
Crime and Punishment in War and Peace: The Counter-Chronological Etiology of the Murder-Apologia Disease
Authors: Meerson Olga A.
Published: March 2022

This article dwells on the author’s initial discovery of a subtext from Crime and Punishment in War and Peace (1994) — something we hardly expect, given the timeline of the historical events addressed in each novel. Ideologically, however, the influence goes from Dostoevsky to Tolstoy, not the other way around. In the scene of the Fire of Moscow in War and Peace, describing how Pierre Bezukhov becomes afflicted with the idée fixe of the Great Man affording to murder for the benefit of humanity, an idea initially ascribed to Napoleon, Tolstoy intertextually dwells on the image of Rodion Raskolnikov, his story, and ideology, presented by Dostoevsky as clinical etiology.
“The Dream of a Ridiculous Man” in Contemporary Theatrical Productions
Authors: Magaril-Il’iaeva Tatiana G.
Published: March 2022

The article is dedicated to three solo performances based on Fyodor Dostoevsky’s fantastic story “The Dream of a Ridiculous Man”, currently running on Italian and Russian stages (the first show is produced by OUT-OFF Theatre in Milan, Italy, starring Mario Sala, and premiered in 2019; the second by the Nikitsky Gate Theatre, directed by and starring Nikolay Ringburg, premiered in 2021; the third by Piotr Fomenko Workshop Theatre, directed by and starring Fyodor Malyshev, premiered in 2015). Particular attention is given to the analysis of staging solutions used in the hero’s description of the new land and its subsequent fall, thus identifying the reasons noticed by the creators of the shows for man’s forsaking of paradise. The article also examines how the producers understood and expressed the idea of “ridiculous” as the comprehension and interpretation of this concept turned out to be an important step in the realization of all three shows. The article employs fragments of the interviews taken by members of the Editorial Department of the journal Dostoevsky and World Culture. Philological journal.
“Why Is This About Dostoevsky?” Or On the Vicissitudes of the Restoration of Darovoe
Authors: Bessonova Albina S. , Viktorovich Vladimir A.
Published: March 2022

The fourth of a series of articles dedicated to the restoration and museification of the memorial space of Darovoe — Monogarovo — Cheremoshnya. Dostoevsky’s Darovoe Museum-Estate opened anew on November 20th, 2021, while the restoration of the Church of the Descent of the Holy Spirit is still running. The authors of the article concentrate on the pressing issues of the ongoing processes and suggest reflecting on the basic principles ruling contemporary Russian restorers. The directives of the “Venice Charter” (1964), when absolutized, lead as in this case to the destruction of authenticity. Instead of Dostoevsky’s estate, we end up with Ivanov’s, and instead of the Church Dostoevsky looked at, we canonize the architectural preferences of the archpriest of the Church at the beginning of the 20th century. Of particular concern is the fate of the Linden Grove, now on the edge of disappearance. The causes of the losses we are witnessing are academic as well as social and moral.
Crime and Punishment: How to Create a Deep Text
Authors: Kasatkina Tatiana A.
Published: March 2022

Through microanalysis, the article shows the instruments used by Dostoevsky to create a text of great depth in his novel Crime and Punishment. An excerpt of Marmeladov’s speech on how he got his last job is analyzed, recurring to other episodes of the novel where the author works with biblical quotations or significant names in a similar way (for example, is shown the shift of meaning in the name Afrosinyushka). It is shown how in Crime and Punishment micro quotes from a “denunciatory” biblical text do not always concur to discredit the character the words refer to or the person who pronounces them. It is demonstrated how Dostoevsky when theologizing in literary works uses micro references to Scriptures in a complex way: not as a secret way to propose to the reader his judgment, but to explain to the reader his role towards the world and people around him (i.e., not morally, but ontologically).
PROGRAMA DE MENTORIA ONLINE: UMA PROPOSTA DE INDUÇÃO DOCENTE
Authors: Ferreira Lúcia Gracia
Published: March 2022

Este texto tem como objetivo apresentar o Programa de Mentoria Online da Universidade Estadual do Sudoeste da Bahia (UESB), Campus de Itapetinga-BA e as primeiras contribuições para o desenvolvimento profissional docente. Buscamos refletir sobre a indução profissional docente e as possibilidades formativas projetada por ela, a partir desse Programa implementado na UESB como atividade de extensão. Todos os dados foram produzidos a partir de uma pesquisa qualitativa, exploratória-descritiva e de intervenção. As narrativas das participantes se deram a partir dos relatos escritos que se configuravam atividades do programa. Os dados mostraram que muitas são as dificuldades para consolidação de um programa desta natureza, mas que muitas também são as contribuições para o processo formativo, ingresso e consolidação na carreira docente. Dessa forma, consideramos que as aprendizagens construídas em torno do programa fomentaram reflexões sobre a necessidade de políticas de indução docente.