bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengadaan Fasilitas untuk Penyandang Disabilitas di Ambarrukmo Plaza Yogyakarta Sesuai dengan Peraturan Perundang-Undangan
Authors: Laksono Rizki Sandi , Permatasari Ane
Published: February 2023

The existence of Yogyakarta Special Region Regulation No. 4 of 2012 on Protection and Fulfillment of The Rights of Persons with Disabilities shows that the DIY Regional Government strives to fulfill the rights of persons with disabilities. In DIY Regional Regulation No. 4 of 2012 on Protection and Fulfillment of The Rights of Persons with Disabilities regulates accessibility in the use of public facilities for persons with disabilities. Research is conducted using qualitative descriptive research methods and data obtained from interview results, documentation, and observations. Based on research conducted by the authors, DIY Regional Regulation No. 4 of 2012 on the Protection and Fulfillment of The Rights of Persons with Disabilities has not been effective because there are no sanctions for violators of the rights of persons with disabilities in the accessibility of the use of public facilities in DIY Regional Regulation No. 4 of 2012 on the Protection and Fulfillment of The Rights of Persons with Disabilities. Meanwhile, in Ambarrukmo Plaza as one of the malls located in Yogyakarta Special Region has provided facilities and companion for people with disabilities, such as wheelchairs, elevators, toilets, and parking spaces. Although facilities for people with disabilities are already available at Ambarrukmo Plaza, they do not meet the criteria set. People with disabilities with visual impairment and deafness must also be accompanied, due to the lack of facilities such as signage and information speakers.
Social Life of Scavengers in The Sukawinatan Landfill in Palembang, Indonesia
Authors: Sartika Diana Dewi , Sununianti Vieronica Varbi , Susanto Tri Agus
Published: February 2023

Scavengers is one of the marginal communities in urban areas, including in Palembang City. The presence of scavengers in this city is illegal, because it is considered to interfere with the activities of the management, which is authorized to manage waste at the Sukawinatan Landfill, Palembang. This case study research is concerned to discern at the social life, threats and opportunities of the scavenger community in Sukawinatan Landfill. This study is conducted to determine strategic steps for improving the scavengers' life in the future. This study is carried out qualitatively. Therefore, in-depth interviews, observation and documentation are used as a way of collecting data. In-depth interviews were conducted to scavengers, informal leader and also the stakeholders. Data is analyzed through reduction, data presentation and making conclusion process. The results of the study indicate that the physical environment of the scavenger community is bad. Meanwhile, according to the in-depth interview and literatures review, some aspects of the social life of scavengers, actually worsen their quality of life, such as: drugs and low education. Nevertheless, there is hope that can be maximized to improve the quality of life of this community, such as: communality and kinship. The description of the scavenger social life can be used as a basis in formulating appropriate interventions for improving the quality of life in this scavenger community.
Pengelolaan Alokasi Dana Desa (ADD) Terhadap Pembangunan Gampong
Authors: Amin Husin
Published: February 2023

This research aims to find out how the system of utilizing Village Fund Allocation (ADD) in the construction of facilities and infrastructure in Babul Makmur village of west Simeulue district. The location of this research is in Babul Makmur Village using descriptive research methods. The results showed that the use of Village Fund Allocation (ADD) in the construction of facilities and infrastructure starts from facilitating work and can be carried out properly, while utilization in increasing productivity is not affected. Furthermore, utilization by increasing effectiveness in the development of facilities and infrastructure can run and have an impact on the community because it can help the community improve its welfare. In addition, factors that affect activities are the absence of delays in disbursement of village funds and lack of public awareness of village development. The advice in this study is that the village government should increase socialization about the use of village funds and increase the commitment and consistency of the government and the community in order to carry out activities in the form of cooperation.
Gaya Kepemimpinan Kepala Desa dalam Meningkatkan Kinerja Pelayanan Publik di Desa Sungai Kedukan
Authors: Putri Aisyah Septia , Febriyanti Doris , Amaliatulwalidain Amaliatulwalidain
Published: February 2023

This study aims to analyze the Leadership Style of the Village Head, as the initial argument in this study, that village officials and village heads are the lowest community service base. This research is a type of qualitative research with research informants are the Village Head and Sungai Kedukan Apparatus, data collection using documentation, observation and in-depth interviews. The data analysis used consisted of data reduction, data presentation, and drawing conclusions. The results showed that the Village Head applied several approaches such as the Situational approach using the Hersey and Blanchard theory, namely Telling, Selling, Participating and Delegating, with this approach making it easier for leaders to improve performance in public services. With a leader, there are those who provide encouragement, input and guidance to subordinates or employees at work.
Efektivitas Program Pendaftaran Tanah Sistematis Lengkap (PTSL) di Badan Pertanahan Nasional (BPN) Aceh Barat
Authors: Almira Nindha , Sari Nurhaslita
Published: February 2023

The Complete Systematic Land Registration Program is a simultaneous land registration activity for the first time throughout Indonesia in one village area where there are still people whose land has not been registered. The Complete Systematic Land Registration Program has been regulated in Presidential Instruction Number 2 of 2018 concerning Acceleration of Complete Systematic Land Registration throughout Indonesia. The purpose of this program is to accelerate the provision of legal certainty and legal protection of community lands in a sure, fair and safe manner. And this study aims to determine the effectiveness of the PTSL program at the West Aceh National Land Agency. This study uses qualitative research methods with a descriptive approach and data collection is done by interview. The results obtained in this study are the implementation of the PTSL program at the National Land Agency of West Aceh has been carried out in accordance with the Regulation of the Minister of Agrarian Affairs and Spatial Planning Number 12 of 2017 and the stages of implementing the PTSL program such as planning for location determination, preparation, formation and appointment of the Land Registration Adjudication Committee. Complete Systematic, counseling, physical and juridical data collection, data research/land inspection, completion of PTSL activities, recognition and granting of rights, bookkeeping and certificate issuance. Based on the research results, the implementation of the PTSL program at BPN Aceh Barat has been effective.
Implementasi Kebijakan dan Komunikasi Antar Organisasi dalam Optimalisasi Kelembagaan Dinas Perijinan dan Penananaman Modal
Authors: Widaningsih M. , Vebritha Silvy , Muharam Husni
Published: February 2023

To improve the economic capacity of a region, one of which is by investing in accordance with the paradigm of Endogenous Development strategy, which is to harmonize natural forces with human resource strengths. However, we still encounter many problems when we are about to make this investment, one of the problems is related to licensing which is still very complicated, requires a very long and complicated bureaucratic route. This is what prompted the researchers to conduct research on what is the problem with the difficulty of the licensing process. The researcher conducted this research using a qualitative research method in which he analyzed data from interviews with informants involved in the investment. The results obtained in this study are that there is still a large gap between investment interest and investment realization, which is one of the reasons for the weakness in policy implementation and communication between organizations.
Análise linguística nos documentos curriculares do ensino fundamental da Região Norte
Authors: Moura Roseli Bitzcof de , Fuza Ângela Francine
Published: February 2023

Este artigo discute como os documentos curriculares da Região Norte do Brasil, pós-BNCC (BRASIL, 2017), abordam a Análise Linguística (AL), a fim de possibilitar reflexões sobre essa prática. Trata-se de estudo documental, sob os pressupostos da Linguística Aplicada, ancorado na perspectiva dialógica de linguagem e no percurso histórico sobre Ensino Gramatical (EG), Prática de Análise Linguística (PAL) e Análise Linguística Dialógica (ALD). Os resultados revelam que os documentos seguem as mesmas evidências de AL, propostas pela BNCC, e que a PAL embasa os textos introdutórios. Contudo, a reorganização curricular expressa perspectivas EG e PAL e poucas de ALD.
A expansão das consciências socioideólogica e linguística em prática de análise linguística de perspectiva dialógica
Authors: Polato Adriana Delmira Mendes , Menegassi Renilson José
Published: February 2023

Neste artigo, defende-se que as consciências socioideológica e linguística dos sujeitos em situação de ensino e aprendizagem da língua são expandidas a partir de prática de análise linguística de perspectiva dialógica, com o trabalho de atividades epilinguísticas valorativas. Ancora-se na perspectiva sociológica e dialógica de linguagem do Círculo de Bakhtin para discutir conceitos sustentadores e balizadores da discussão, como consciência socioideológica, signo ideológico, discurso interior, tema, entonação e outros, em enunciado produzido por deputado brasileiro em 2022. As discussões demonstram como as atividades epilinguísticas, em diferentes categorias, enfocam o plano axiológico-ideológico da língua/discurso e medeiam a interação autor-interlocutor-tema no enunciado, a inter-relacionar e promover a expansão das consciências socioideológica e linguístico-enunciativo-discursiva.
A prática de análise linguística e a produção de atividades didáticas: o que (ainda) precisamos construir em contexto de formação inicial de professores de língua portuguesa
Authors: Barreto Taís Vasques , Pinton Francieli Matzenbacher
Published: February 2023

Considerando resultados que evidenciam a reprodução de “modelos e práticas gramaticais tradicionais” (ROHLING; REMENCHE, 2015) e a recorrência de “enunciados que demandam apenas reconhecimento de categorias gramaticais” em atividades de análise linguística (PINTON; SILVA, 2021), este artigo objetiva verificar em que medida a prática de análise linguística é contemplada em atividades didáticas produzidas por duas professoras em formação inicial em termos de natureza das atividades, níveis de complexidade requeridos e estratos de linguagem contemplados. Para isso, nesta investigação, focalizamos o contexto formativo de professores de Letras em uma universidade federal do interior do Rio Grande do Sul, especificadamente a disciplina Leitura e Produção textual – Prática de Análise Linguística no Contexto Escolar.
Abscess-like postpartum metaplastic breast carcinoma in breastfeeding woman: a case report
Authors: Ferrari Bianca Gardini , da Silva Gabriela Fiorentino , Rodrigues Marcela Martins , Rodrigues Rafaela Martins , da Silva Sá Rafael , Kerche Leandra Ernst
Published: February 2023

Introduction: Breast cancer diagnosed within 10 years of parturition is named postpartum breast cancer which is a highly metastatic tumor with poor prognosis.

Case Report: A 31-year-old female presented with fever and painful mass in the left breast. She had undergone C-section 6 months ago of her second child. A left breast biopsy was performed and showed estrogen receptor-negative, progesterone receptor-negative, and human epidermal growth factor receptor 2 (HER2) negative invasive highly differentiated carcinoma. A radical mastectomy and left axillary lymphadenectomy were then performed and the anatomopathological report showed a 16cm metaplastic breast carcinoma. Eight months after the start of the chemotherapy treatment, the patient was diagnosed with brain metastases.

Discussion: Postpartum breast cancer is associated with worse survival rates presenting increased risk of death. Metaplastic breast carcinoma is a subtype of triple-negative breast cancer also associated with poor prognosis and chemotherapy treatment resistant, being surgery the standard treatment.
Den russiske verdensorden før og efter Ukrainekrigen
Authors: Hansen Flemming Splidsboel
Published: February 2023

Den politiske debat i Rusland har i mange år haft et element om en kommende verdensorden. Der har generelt været enighed om, at tilstanden efter ophøret af den kolde krig var uholdbar, og at noget andet og mere blivende ville erstatte den påståede USA-ledede orden. Denne debat er blevet mere akut efter Ruslands invasion af Ukraine den 24. februar 2022. Ruslands præsident Vladimir Putin har efter invasionen rakt ud til især Det globale Syd, og han har ved en række lejlig-heder talt om en ny og mere demokratisk, inkluderende og respektfuld orden. Det er dog vanskeligt at vurdere, i hvilken udstrækning hans løfter skyldes behovet for at skabe nye alliancer, og hvor megen reel vilje der er i Moskva til at reformere fx FN-systemet og lade lande fra Det globale Syd få mere indflydelse.
The alliance between China and Russia and the rivalry between China and the USA in light of the war in Ukraine
Authors: Xing Li
Published: February 2023

This article aims to explain and analyze the complexity of the Ukraine War by scrutinizing two important factors – the China-Russia alliance and the China-US rivalry. The article demonstrates that these two factors and their interconnections largely determine the nature and trend of the developing world order. Beijing’s position on the Ukraine War reflects its strategic calculations through the lens of great power rivalry between itself and Washington. The China-Russia alliance is a utility, and the Ukraine War is a good situation for Beijing and Russia to promote a new international security architecture that is not dominated by the West. The article concludes that Russia’s war in Ukraine combined with the China-US rivalry and decoupling is propelling the return of conventional geopolitical competition and division. The fact that the world is divided over these events shows that we may be heading towards a multi-order world.
How Russia’s war strengthens the West
Authors: Larsen Henrik
Published: February 2023

This article highlights three key areas of Western adaptation to Russia’s war against Ukraine with advice for how to optimize them going forward. First is the immediate strengthening of NATO’s conventional defense against Russia, whose sustainability will depend on European contributions, as the US increasingly will focus on Asia. Second is the preservation of joint resilience against both Russia and China, in which NATO should stick to the narrow military areas and the EU to the broader civilian areas. Third is the question of Ukraine as part of the West, where the former’s poor reform record and the latter’s unwillingness to intervene militarily on its behalf draw the realistic scenario of the country’s continued association.
The recalibration of the Russian military to a war of attrition
Authors: Gjerstad Michael
Published: February 2023

This article provides an overview of Russia’s military capabilities in light of the war in Ukraine and what adaptations the Russian military has made in connection with the mobilization on 21 September 2022. This is examined by highlighting the military theoretical assumptions regarding the conduct of operations prior to the invasion, and how the adjustment to a war of attrition breaks with these previous military theoretical assumptions. The main question examined in the article is what significance this adaptation of the Russian military has in relation to the future of Russian military power and its ambitions for a Russian-led international order.
B cell receptor-induced IL-10 production from neonatal mouse CD19+CD43- cells depends on STAT5-mediated IL-6 secretion
Authors: Sakai Jiro , Yang Jiyeon , Chou Chao-Kai , Wu Wells W , Akkoyunlu Mustafa
Published: February 2023

Newborns are unable to reach the adult-level humoral immune response partly due to the potent immunoregulatory role of IL-10. Increased IL-10 production by neonatal B cells has been attributed to the larger population of IL-10-producting CD43+ B-1 cells in neonates. Here, we show that neonatal mouse CD43- non-B-1 cells also produce substantial amounts of IL-10 following B cell antigen receptor (BCR) activation. In neonatal mouse CD43- non-B-1 cells, BCR engagement activated STAT5 under the control of phosphorylated forms of signaling molecules Syk, Btk, PKC, FAK, and Rac1. Neonatal STAT5 activation led to IL-6 production, which in turn was responsible for IL-10 production in an autocrine/paracrine fashion through the activation of STAT3. In addition to the increased IL-6 production in response to BCR stimulation, elevated expression of IL-6Rα expression in neonatal B cells rendered them highly susceptible to IL-6-mediated STAT3 phosphorylation and IL-10 production. Finally, IL-10 secreted from neonatal mouse CD43- non-B-1 cells was sufficient to inhibit TNF-α secretion by macrophages. Our results unveil a distinct mechanism of IL-6-dependent IL-10 production in BCR-stimulated neonatal CD19+CD43- B cells.
Assessment of DNA Ploidy in Oral Potentially Malignant Disorders Using a VELscope
Authors: Das Pushpanjali , Deshukh Revati Shailesh
Published: February 2023

Introduction: The device VELscope (Visually enhanced lesion scope) is intended as an aid to the clinician to complement a conventional white light exam (whether it be a general oral cavity examination or examination of a particular lesion) to detect abnormal tissue that might have otherwise been overlooked. In this study, it was used concomitantly with ploidy status to evaluate the malignancy potential of Oral Potentially Malignant Disorders (OPMD). Aim: To evaluate potential of Deoxyribonucleic Acid (DNA) ploidy as a preliminary adjunct to oral biopsy to identify patients with aneuploidy for the necessity of biopsy, and to assess the sensitivity of VELscope in the determination of accurate clinical parameters of the lesions in the oral mucosa. Materials and Methods: This in-vivo cross-sectional study was carried out in Department of Oral and Maxillofacial Pathology and Oral Microbiology, Bharati Vidyapeeth Deemed to be University, Pune from February 2020 to February 2021. Clinically diagnosed OPMD were included in the study, after verification of clinical extension boundaries by VELscope. DNA ploidy status was evaluated with DNA image cytometry and exclusive individuals with aneuploidy were biopsied followed by histopathological evaluation and surgical removal of the lesion. One way Analysis of Variance (ANOVA) test was used to compare the mean in 4 study groups [Oral leukoplakia, Oral submucous fibrosis, Oral lichen planus and Tobacco pouch keratosis] vs control. Sensitivity, specificity, positive predictive value and negative positive value was calculated by using the ROC (Receiver Operating Characteristic Curve) analysis. A p-value <0.05 was considered as significant for evaluating sensitivity of VELscope and evaluation of ploidy status. Results: The study included patients whose mean age was 45.8 years. The groups had tobacco habits in one of the various forms [smoke or smokeless] both in experimental and control group. VELscope could identify the clinical borders of the OPMDs considered via the loss of autofluorescence. Lesion borders were identified precisely with the loss of autofluorescence. It was quite helpful especially in aneuploid cases where the whole margin could be removed leaving no genetically aberrant cells behind. Oral submucous fibrosis was concluded to have maximal sensitivity of 86.7%, 100% in specificity and positive predictive and 88.2% negative predictive value. Conclusion: DNA ploidy could decipher the malignancy potential and could identify the individuals who needed biopsy. VELscope was able to mark the clinical diameters which were not visible to naked eyes clinically. Oral submucous fibrosis was found to be group with the maximum potential of malignancy followed by Oral Lichen Planus, Oral Leukoplakia and Tobacco Pouch Keratosis.
Repercussions of Consanguinity on Metrical Traits At Different Phases of Growth
Authors: Begum Gulrukh
Published: February 2023

Introduction: Consanguinity is associated with increase in the likelihood of receiving two copies of deleterious gene from parents, which brings the hidden recessive disorders. This further increases the risk of neonatal and post neonatal mortality. Some of which may also have negative effect on metrical traits of the children, thereby affecting their development and reducing their cognitive abilities. Aim: To examine the effect of parental consanguinity on various metrical traits like linear, circumferential and weight measurements among the Muslim males. Materials and Methods: A cross-sectional study was conducted amongst the Muslim males living in the different river islands of Barpeta district in Assam. The study consisted 1438 males (587 inbred and 851 non-inbred). A total of 936 boys (3 years to 18 years) were measured at an interval of one year. The rest (502 adult men) from 19 to 60 years were in age cohorts of five-years age interval. They were measured for stature, sitting height, lower extremity length, body weight, waist circumference, abdominal circumference and hip circumference. Inbreeding depression on trait was calculated using average coefficient of inbreeding and % of depression in a trait. Wright’s path coefficient method was used for the calculation of inbreeding coefficient. Results: The average coefficient of inbreeding was found to be 0.01637931154. A significant increase in the difference of mean values in all the linear, circumferential and weight measurements has been observed at many ages with the increase in the inbreeding coefficient during childhood and adolescence phase of life. But the difference in mean variance in the adult body parameters between the inbred and non-inbred was statistically insignificant at almost all ages (p>0.05). Conclusion: Consanguinity has not affected any of the adult body measurements. A significant positive association between consanguinity and diminution of body measurements found during the growing period needs to be correlated with the other socio demographic variables because the growing period is always more dependent on environmental variables.
Conservation Agriculture Technology: Extent of Adoption & Constraints Faced by Farmers of Madhya Pradesh, India
Authors: Bilaiya Shrishti , Khare N. K. , Sahu Ankita , Patidar Jitendra
Published: February 2023

Increase in human population and vigorously changing climate leading to declining natural resource are the emerging challenges for the world's agricultural systems, which need to produce more food for the increasing population. Therefore, change in our conventional agriculture practice is required by adapting practices or technology helping in coping up with the changing climate and sustainably using the resources for future productivity gains and Conservation Agriculture (CA) Technology is one of the best alternative. CA is a resource conservation practice which improves biodiversity and natural biological processes above and below the ground surface and includes a trifecta of no-till or minimum-till or zero-till farming, permanent soil cover and crop rotations which have existed for nearly a century, but its uptake has generally been slow and uneven. Present study was conducted at state Madhya Pradesh of India using ex-post facto research design to find out the extent of adoption along with the constraints faced by the farmer in adoption of this decade older technology. The study revealed that despite the proven benefits of CA, its adoption rate is very slow in the region. Further, majority of the farmers had moderate knowledge of CA but were afraid to adopt it completely. The major reason witnessed were complexity of CA in comparison to conventional agriculture, lack of awareness of this technology among farmers and high cost and unavailability of happy seeder.
Quality of Bread Wheat (Triticum aestivum L.) as Influenced by Different Nutrient Management Approaches under Northern Transitional Zone of Karnataka
Authors: Sanadi Ummesalma , Math K. K. , Lamani Kumar D. , Reddy Uday G.
Published: February 2023

The field experiments were conducted at the Research Farm of AICW&BIP, Main Agricultural Research Station, University of Agricultural Sciences, Dharwad during rabi 2020-21 and 2021-22 and was laid out in Randomized Complete Block Design with 15 treatments replicated thrice to evaluate the performance of wheat quality to various nutrient management approaches. The pooled data onto two years indicated that application of 275:40.33:135.2 kg of N:P2O5:K2O ha-1 for yield target of 55 q ha-1 under SSNM practices significantly increased the protein content  (13.43 %), wet gluten (34.7 %), dry gluten (11.9 %), gluten index (81.6 %), sedimentation value (46.3 ml) and yellow pigment (5.93 ppm) in wheat grain and it was found on par with yield targets at 50 and 45 q ha-1 under SSNM.
Role of Diffusion Weighted MRI and Contrast Enhanced MRI in Diagnosis of Uterine Cervical Mass
Authors: Mostafa Elsharkh Ebtsam , Yousef Ismael Mohammed Ahmed , Mohamed Mashaly Emad
Published: February 2023

Background: Cervical cancer is one the most frequently diagnosed malignant diseases in females, affecting approximately 16 out of 100 000 women. Diffusion-weighted (DW) MRI is a newly developed technique characterized by an apparent diffusion coefficient (ADC). The reason for this work was to investigate the role of DW and contrast enhanced MRI (CE) in diagnosis of uterine cervical mass to differentiate a benign from cancerous lesions.

Methods: This prospective study was done on 20 patients with uterine cervical masses. All patients were subjected to Personal, Past, Family history taking. Comprehensive clinical examinations Ultrasound: Previous pelvi-abdominal US, TVUS and Laboratory investigations including renal and liver functions and pregnancy test.  

Results: The majority of patients (65%) had cervical masses in supravaginal portion while 35% had lesions in vaginal portion. The mean value of DWI findings was 0.88± 0.25. There was statistically significant increase in the size of mass in cases with malignant tumour compared to a benign one (p= 0.012). There was a significant increase in DWI findings in benign group compared to malignant group (p <0.001). The ROC curve showed that the best cut off of DWI was ≤ 0.9 with 100% specificity and sensitivity.

Conclusions: DWI could significantly predict patients with malignant lesion of uterine cervical mass at cut off value ≤ 0.9 with 100% accuracy, 100% sensitivity, 100% specificity, 100% PPV and 100% NPV.
Artificial Neural Network and Its Application in Image Recognition
Authors: Wang Chunyu , Wang Lujie
Published: February 2023

Computer vision technology refers to the technical vision that uses cameras and computers to replace human eyes to recognize, track and measure objects. Image recognition (image object recognition and detection) is one of its basic tasks. The key to accomplish this task is the artificial neural network model and algorithm. With the continuous improvement of neural network model, image object recognition technology has also been steadily improved. In this paper, the origin, types and development history of artificial neural network are introduced, and its application in image recognition is reviewed.
Perancangan Media Kreatif “Brainlliant” untuk Anak Penderita Epilepsi
Authors: Kosasih Evelyn Euginia , Wahyudi Anang Tri
Published: February 2023

Penyakit epilepsi masih menjadi hal yang jarang diketahui oleh masyarakat, karena umumnya pada kepercayaan yang terbentuk, epilepsi sering dikaitkan dengan roh jahat. Nyatanya penyakit ini memang merupakan gangguan pada saraf di otak yang membuat penderitanya kejang-kejang. Penyakit ini juga lebih sering menyerang anak-anak. Keterkaitan epilepsi dan depresi sangatlah dekat. Rasa kurang percaya diri, stress atau bahkan rasa sakit kejang-kejang yang tak kunjung henti bisa membuat penderitanya depresi. Target audiens merupakan teman-teman penderita epilepsi berusia 5-12 tahun. Dengan adanya media kreatif ini diharapkan bisa membantu rasa percaya diri, edukasi untuk berfikir positif serta penyaluran bakat atau kreatifitas bagi teman-teman epilepsi.
Perancangan Game Visual Novel “Freshmen” sebagai Media Edukasi Etika Bermedia Sosial Sekolah Menengah Atas
Authors: Naratama Andreas , Prasida T. Arie Setiawan , Prestiliano Jasson
Published: February 2023

Media sosial merupakan sarana komunikasi yang digunakan di era modern. Akan tetapi penggunaan media sosial tidak selalu berdampak positif, pelanggaran hukum sering terjadi di media sosial seperti ujaran kebencian dan penyebaran hoax. Kalangan SMA menjadi salah satu kalangan yang rawan menjadi korban atau pelaku pelanggaran di media sosial dikarenakan tingkat emosi yang belum stabil walau sudah dapat berpikir secara kritis. Solusi berupa media pembelajaran berbentuk game edukasi Visual novel berjudul “Freshmen” dikembangkan dengan tujuan untuk mengedukasi siswa SMA akan pentingnya etika dalam bermedia sosial. Metode yang digunakan dalam penelitian adalah satistik deskriptif. Hasil evaluasi menunjukan bahwa siswa menjadi lebih paham tentang etika dalam bermedia sosial setelah bermain game “Freshmen”.
Perancangan Poster Augmented reality Dampak Sampah Plastik bagi Lingkungan
Authors: Adam Chairoel
Published: February 2023

Sampah plastik merupakan salah satu jenis sampah yang banyak dihasilkan oleh masyarakat pada saat ini. Kesadaran yang kurang dari masyarakat untuk mengurangi penggunaan dan mengolah kembali sampah plastik ini menyebabkan penumpukan sampah yang berlebihan di lingkungan. Melihat permasalahan yang ada, maka akan dirancang sebuah poster tentang bahaya sampah plastik bagi lingkungan menggunakan fitur augmented reality sebagai solusi kreatif yang dapat menarik perhatian masyarakat untuk mencermati poster tersebut dan menyebarluaskannya melalui media sosial. Poster ini dirancang menggunakan metode Design Method oleh Eric Karjaluoto, dengan harapan poster ini nantinya dapat meningkatkan kesadaran tentang bahaya sampah plastik dan mengurangi penggunaan plastik yang berlebihan.
Two-Year Outcomes After Variable Duration of Drug Cessation in Patients With Maculopathy Associated With Pentosan Polysulfate Use
Authors: Jung Emily H. , Lindeke-Myers Aaron , Jain Nieraj
Published: February 2023

Importance

Prior retrospective studies have provided limited evidence on disease progression following drug cessation in patients with maculopathy associated with pentosan polysulfate (PPS).

Objective

To evaluate the 2-year evolution of maculopathy associated with PPS use after drug cessation.

Design, Setting, and Participants

This cohort study prospectively evaluated the natural history of patients with maculopathy associated with PPS use. Participants seen at the Emory Eye Center were enrolled between December 1, 2018, and December 1, 2019, and data were collected through November 30, 2021.

Main Outcomes and Measures

The main outcomes were changes in visual function and structure. Visual function was assessed annually with refraction and Early Treatment Diabetic Retinopathy Study (ETDRS) best-corrected visual acuity (BCVA), mesopic microperimetry, and dark adaptometry. Structural outcomes included presence and extent of complete retinal pigment epithelium and outer retinal atrophy (cRORA), macular central subfield thickness (CST), and subfoveal choroidal thickness (SFCT).

Results

Of the 12 participants (23 eyes), 11 (91.7%) were female (1 [8.3%] male), 11 (91.7%) were White (1 [8.3%] Black), and median (IQR) age at enrollment was 58 (47-64) years. Median (IQR) time from PPS discontinuation to initial visit was 0.6 (0.4-1.9) years. Median baseline ETDRS BCVA letter score was 83 (Snellen equivalent, 20/20) (IQR, 80-86.5 [20/25-20/20]), with a median 2-year change of −3 (IQR, −6 to −0.5; P = .08). Four eyes (17.4%) had a letter score decline of 15 or more, all associated with progressive cRORA. Median change in microperimetry average threshold was −3.5 dB (IQR, −4.1 to −2.5 dB; P = .001), and percent reduced threshold was 32.5% (IQR, 20.3%-52.8%; P = .004). Nine eyes (39%) had macular cRORA at baseline, with a median linearized growth rate of 0.23 mm/y (IQR, 0.22-0.25 mm/y). Two eyes (8.7%) without atrophy at baseline developed new-onset cRORA. Median baseline CST was 284 μm (IQR, 253-291 μm), with a median 2-year change of −5 μm (IQR, −13 to 0.5 μm; P = .0497). Median 2-year change in SFCT was 1 μm (IQR, −18 to 16 μm; P = .91).

Conclusions and Relevance

The findings of this cohort study suggest that functional and structural deficits continue to progress in PPS-associated maculopathy even after drug cessation. Additional study is needed to determine whether these findings can be generalized to other patients with PPS-associated maculopathy and whether longer follow-up could determine subsequent disease course.
Four‐dimensional computed tomography‐based ventilation imaging in intensity‐modulated radiation therapy treatment planning for pulmonary functional avoidance
Authors: Iqbal Gazi Md Daud , Zhang Hao , D'Souza Wareen , Ha Lidan , Rosenberger Jay M.
Published: February 2023

Purpose

To incorporate four‐dimensional computed tomography (4DCT)‐based ventilation imaging into intensity‐modulated radiation therapy (IMRT) treatment planning for pulmonary functional avoidance.

Methods and Materials

Nineteen locally advanced lung cancer patients are retrospectively studied. 4DCT images are employed to create ventilation maps for each patient via a density‐change‐based algorithm with mass correction. The regional ventilation is directly incorporated into the mathematical formulation of a direct aperture optimization model in IMRT treatment planning to achieve functional avoidance and a voxel‐based treatment plan. The proposed functional avoidance planning and voxel‐based planning are compared to the conventional treatment planning approach purely based on the anatomy of patients. Paired sample t‐tests are conducted to see whether dosimetric differences among the three approaches are significant.

Results

Similar planning target volume (PTV) coverage is achieved by anatomical, functional avoidance, and voxel‐based approaches. The voxel‐based treatment planning performs better than both functional avoidance and anatomical planning to the lung. For a total lung, the average volume reductions in a functional avoidance plan from an anatomical plan, a voxel‐based plan from an anatomical plan, and a voxel‐based plan from a functional avoidance plan are 7.0%, 16.8%, and 10.6%, respectively for V40; and 0.4%, 6.4%, and 6.0%, respectively for mean Lung Dose (MLD). For a functional lung, the reductions are 8.8%, 17.2%, and 9.2%, respectively, for fV40; and 1.1%, 6.2%, and 5.2%, respectively, for functional mean lung dose (fMLD). These reductions are obtained without significantly increasing doses to other organs‐at‐risk. All the pairwise treatment planning comparisons for both total lung and functional lung are statistically significant (p‐value ) except for the functional avoidance plan with the anatomical plan pair in which the p‐value . From these results, we can conclude that voxel‐based treatment planning outperforms both anatomical and functional‐avoidance planning.

Conclusions

We propose a treatment planning framework that directly utilizes functional images and compares voxel‐based treatment planning with functional avoidance and anatomical treatment planning.
Joule Heating of Carbon Fibers and Their Composites in Radio‐Frequency Fields
Authors: Dasari Smita Shivraj , Sarmah Anubhav , Mee Raymond D. , Khalfaoui Aida N. , Green Micah J.
Published: February 2023

Carbon fibers (CFs) show the ability to generate heat when exposed to radio‐frequency (RF) fields, but little is known about the relationship between material properties and heating behavior. The group has previously shown that this heating response can be used for the manufacturing of CF‐reinforced composites. Herein, the effect of electrical conductivity on the RF‐induced Joule heating patterns of CFs is analyzed. Unidirectional CF tows and their composites show different heating rates when their orientations relative to the RF field are changed due to their anisotropic conductivities. It is observed that the CFs and their composites show higher heating responses when they are placed perpendicular to the RF field lines. Herein, an increase in the heating response with increasing conductivity is observed; however, beyond a certain conductivity value, the heating response decreases because the samples with very high conductivities reflect the RF field. Also, the RF‐induced heating of unidirectional CF tows in different orientations is simulated, with qualitative agreement between experimental results and simulations. Herein, the effect of electrical conductivity on field‐induced Joule heating of CFs is explained by the findings of this work; these results pave the way for energy‐efficient, out‐of‐oven processing of thermoset composites at an industrial scale.
Ferromagnetic Mn–Al–C L10 Formation by Electric Current Assisted Annealing
Authors: Maccari Fernando , Zintler Alexander , Brede Thomas , Radulov Iliya A. , Skokov Konstantin P. , Molina-Luna Leopoldo , Gutfleisch Oliver
Published: February 2023

The ferromagnetic Mn–Al–C τ‐phase ( tetragonal structure) shows intrinsic potential to be developed as a permanent magnet; however, this phase is metastable and is easily decomposed to nonmagnetic stable phases, affecting negatively the magnetic properties. Giving the necessity to careful control of its synthesis, the use of a novel approach is investigated using electric current–assisted annealing to obtain pure τ‐phase samples. The temperature and electrical resistance of the samples are monitored during annealing and it is shown that the change in resistance can be used to probe the phase transformation. Upon increase of electric current density, the required temperature for the ferromagnetic phase formation is reduced, reaching a maximum shift of 140 °C at 45 A mm−2. Even though this noticeable shift is achieved, the magnetic properties are not affected showing coercivity of 0.13 T and magnetization of 90 Am2 kg−1, independently from the electric current density used during annealing. Microstructural investigation reveals the nucleation of the τ‐phase at the grain boundaries of the parent ε‐phase. In addition, the existence of twin boundaries upon nucleation and growth of the metastable phase for all evaluated annealing conditions is observed, resulting in similar extrinsic magnetic properties.
Molecular Engineering for Shortening the Pt···Pt Distances in Pt(II) Dinuclear Complexes and Enhancing the Efficiencies of these Complexes for Application in Deep‐Red and Near‐IR OLEDs
Authors: Rajakannu Palanisamy , Lee Woochan , Park Sanghoon , Kim Hyung Suk , Mubarok Hanif , Lee Min Hyung , Yoo Seunghyup
Published: February 2023

Deep‐red (DR)‐to‐near‐infrared (NIR) phosphorescent organic light‐emitting diodes (OLEDs) have potentials for application in various fields ranging from phototherapy to sensing. Accordingly, herein, phenylpyridazine‐based bidentate ligands are synthesized and subsequently utilized for the preparation of dinuclear Pt(II) complexes (1–6). The molecular structures of 1–3 is investigated by single‐crystal X‐ray diffraction, and the results suggest that these complexes have substantially shortened Pt···Pt distances (2.906–2.911 Å). Complexes 1–6 exhibit intense emissions in the NIR region (700–726 nm), high photoluminescence quantum yield (PLQY) (0.11–0.18), and short phosphorescence decay lifetimes (τ = 0.64–0.95 µs) in a CH2Cl2 solution. To examine the effect of N‐substitution on the dinuclear Pt complexes, the phenylpyrimidine‐based Pt(II) emitters 7 and 8 are prepared and discovered to have Pt···Pt distances of 2.933 Å. 7 and 8 demonstrate strong emissions in the 628–650 nm range with high PLQY of 0.52–0.65. Theoretical studies indicate that the functional groups or atoms in the ligands play crucial roles in the formation of emitters with significantly shortened Pt···Pt distances. 3 and 7 are employed as non‐doped emitters to fabricate NIR OLEDs, and the resulting OLEDs exhibit electroluminescence peaks at 754 and 692 nm with maximum external quantum efficiencies of 3.0 and 4.4%, respectively.
Coordination‐Precipitation Synthesis of Metal Sulfide with Phase Transformation Enhanced Reactivity against Antibiotic‐Resistant Bacteria
Authors: Liu Yuan , Wang Xiaonan , Fan Xiaowan , Ge Mengyue , Fang Ling , Yuan Ye , Chen Lei , Jiang Jing , Cao Anmin , Gao Lizeng
Published: February 2023

Given the challenge of bacterial resistance to antibiotics, there is an urgent need to develop alternative antibacterial agents. While some metal sulfides are promising candidates against bacterial resistance, their fundamental mechanism of action (MoA) remains unclear. Herein, a “coordination‐precipitation” method is developed for the synthesis of a metal sulfide library and the evaluation of antibacterial consistency. Employing ethylenediamine as a coordination agent and thioglycolic acid as a precipitation agent, 12 different metal sulfide nanocrystals following the same procedure are synthesized. Antibacterial assessment reveals that six metal sulfides with bactericidal potency perform a common feature of phase transformation. In particular, in the process of manganese sulfide (MnS) transformation to Mn3O4, a highly reactive complex of high‐valance manganese (Mn3+) and polysulfide (S32−) accompanied by superoxide is sustainably generated, which synergistically induces bacterial death with a hallmark of lipid peroxidation (named liperoptosis) specifically toward Gram‐positive Staphylococcus aureus (S. aureus). In addition, this MoA confers MnS with therapeutic effects superior to vancomycin in a methicillin‐resistant S. aureus‐infected skin wound model. This study reveals the correlation between phase transformation and the antibacterial MoA of metal sulfides and provides a general fundamental to design a non‐antibiotic antibacterial candidate against bacterial resistance.
Molecular Modulation of Sequestered Copper Sites for Efficient Electroreduction of Carbon Dioxide to Methane
Authors: Zhang Kefan , Xu Jie , Yan Tianran , Jia Lin , Zhang Jie , Shao Chaochen , Zhang Liang , Han Na , Li Yanguang
Published: February 2023

The sustainable production of methane (CH4) via the electrochemical conversion of carbon dioxide (CO2) is an appealing approach to simultaneously mitigating carbon emissions and achieving energy storage in chemical bonds. Copper (Cu) is a unique material to produce hydrocarbons and oxygenates. However, selective methane generation on Cu remains a great challenge due to the preferential *CO dimerization pathway toward multi‐carbon (C2+) products at neighboring catalytic sites. Herein, a conjugated copper phthalocyanine polymer (CuPPc) is designed by a facile solid‐state method for highly selective CO2‐to‐CH4 conversion. The spatially isolated CuN4 sites in CuPPc favor the *CO protonation to generate the key *CHO intermediate, thus significantly promoting the formation of CH4. As a result, the CuPPc catalyst exhibits a high CH4 Faradaic efficiency of 55% and a partial current density of 18 mA cm−2 at −1.25 V versus the reversible hydrogen electrode. It also stably operates for 12 h. This study may offer a new solution to regulating the chemical environment of the active sites for the development of highly efficient copper‐based catalysts for electrochemical CO2 reduction.
FeCl2‐Catalyzed Rearrangement of Aryl Peroxyoxindole into 1,3‐Benzooxazin‐4‐One
Authors: Mohanta Nirmala , Paramita Samal Pragnya , Krishnamurty Sailaja , Gnanaprakasam Boopathy
Published: February 2023

We report an FeCl2‐catalyzed radical rearrangement of aryl peroxyoxindoles into 1,3‐benzooxazin‐2‐ones to obtain a variety of aryl substituted 1,3‐benzooxazin‐4‐ones in moderate to good yields. Mechanistically, this skeletal rearrangement of peroxyoxindoles proceeded via radical pathway and was well supported with a series of experimental findings and DFT studies.

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4D Printing of Humidity‐Driven Seed Inspired Soft Robots
Authors: Cecchini Luca , Mariani Stefano , Ronzan Marilena , Mondini Alessio , Pugno Nicola M. , Mazzolai Barbara
Published: February 2023

Geraniaceae seeds represent a role model in soft robotics thanks to their ability to move autonomously across and into the soil driven by humidity changes. The secret behind their mobility and adaptivity is embodied in the hierarchical structures and anatomical features of the biological hygroscopic tissues, geometrically designed to be selectively responsive to environmental humidity. Following a bioinspired approach, the internal structure and biomechanics of Pelargonium appendiculatum (L.f.) Willd seeds are investigated to develop a model for the design of a soft robot. The authors exploit the re‐shaping ability of 4D printed materials to fabricate a seed‐like soft robot, according to the natural specifications and model, and using biodegradable and hygroscopic polymers. The robot mimics the movement and performances of the natural seed, reaching a torque value of ≈30 µN m, an extensional force of ≈2.5 mN and it is capable to lift ≈100 times its own weight. Driven by environmental humidity changes, the artificial seed is able to explore a sample soil, adapting its morphology to interact with soil roughness and cracks.
Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors
Authors: Bi Jianling , Witt Emily , Voltarelli Vanessa A. , Feig Vivian R. , Venkatachalam Veena , Boyce Hannah , McGovern Megan , Gutierrez Wade R. , Rytlewski Jeffrey D. , Bowman Kate R. , Rhodes Ashley C. , Cook Austin N. , Muller Benjamin N. , Smith Matthew G. , Ramos Alexis Rebecca , Panchal Heena , Dodd Rebecca D. , Henry Michael D. , Mailloux Adam , Traverso Giovanni , Otterbein Leo E. , Byrne James D.
Published: February 2023

Tumor hypoxia drives resistance to many cancer therapies, including radiotherapy and chemotherapy. Methods that increase tumor oxygen pressures, such as hyperbaric oxygen therapy and microbubble infusion, are utilized to improve the responses to current standard‐of‐care therapies. However, key obstacles remain, in particular delivery of oxygen at the appropriate dose and with optimal pharmacokinetics. Toward overcoming these hurdles, gas‐entrapping materials (GeMs) that are capable of tunable oxygen release are formulated. It is shown that injection or implantation of these materials into tumors can mitigate tumor hypoxia by delivering oxygen locally and that these GeMs enhance responsiveness to radiation and chemotherapy in multiple tumor types. This paper also demonstrates, by comparing an oxygen (O2)‐GeM to a sham GeM, that the former generates an antitumorigenic and immunogenic tumor microenvironment in malignant peripheral nerve sheath tumors. Collectively the results indicate that the use of O2‐GeMs is promising as an adjunctive strategy for the treatment of solid tumors.