bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of Reaction Parameters during the Synthesis of Hexagonal Hexadecylamine Capped ZnS Nanoparticles
Authors: JAWORE ABERA MADISHA , XABA THOKOZANI , NATE ZONDI , NTSOANE TSHEPO , MOLOTO MAKWENA JUSTICE
Published: September 2023

Zinc sulphide nanoparticles capped with hexadecylamine (ZnS-HDA) have been synthesized through thermal decomposition of (Z)-2- (pyrrolidin-2-ylidene)thiourea zinc(II) complex. The effects of temperature, time and concentration of the precursor on the properties of ZnS-HDA capped nanoparticles were investigated. The values of the optical band edges were increasing when the temperature, reaction tim and the amount of the precursor were elevated. X-ray diffraction patterns of all the synthesized nanoparticles mainly exhibited hexagonal phase structures. The morphologies of the particles were increasing with the increase in temperature, time and precursor concentration.
Comparative Studies of Fatty Acid Methyl, Ethyl and i-Propyl Esters of Tamarindus indica Seed Oil as Biodiesel Base-Stock
Authors: RAJAK AMIT KUMAR , M.S. L KARUNA , DEVERAPAGA MADHU , VIDAVALUR SIDDAIAH , PADMAJA KORLIPARA V.
Published: September 2023

The unsaturated fatty acids found in tamarind seed oil include oleic acid (16.0%), linoleic acid (56.0%), palmitic acid (8.0%) and stearic acid (4.0%). The free fatty acids (0.6%) present in the tamarind seed oil was converted to methyl, ethyl and isopropyl esters. Further, the base stocks were prepared by employing transesterification reaction catalyzed by a base. Biodiesel fuels thus prepared were evaluated for different parameters and methyl esters were found to show ester content (97.3%), density (0.86315 g/cm3), acid value (0.42), oxidation stability (1.49 h), flash point (137.2 °C) and kinematic viscosity (5.09 cSt), ethyl esters have shown a kinematic viscosity (5.54 cSt), density (0.87030 g/cm3), acid value (0.45), oxidation stability (2.16 h), flash point (141.2 ºC), ester content (97.7%) and isopropyl esters exhibited kinematic viscosity (20.05 cSt), density (0.9220 g/cm3), acid value (0.58), oxidation stability (0.05 h) and flash point (145.3 ºC). The study involved investigation of effectiveness of four different antioxidants namely, butylated hydroxyl toluene (BHT), butylated hydroxyl anisole (BHA), t-butyl hydroxyl quinone (TBHQ) and diphenylamine (DPA) in different concentrations to the prepared methyl and ethyl biodiesels. BHA and BHT were observed to exhibit enhanced oxidation stability of produced biodiesel. The physical and chemical properties of methyl and ethyl esters were found to lie within EN and ASTM specifications.
2,7-Dichlorofluorescein Hydrazide loaded Zeolite HY: Colorimetric, Paper Strip and Fluorescent Sensor for Cu2+
Authors: KALITA SAROJMONI , DAS DIGANTA KUMAR
Published: September 2023

In this work, 2,7-dichlorofluorescein dye is successfully loaded into zeolite HY and investigated as chemosensors. The synthesized sensor was characterized by various instrumental techniques. The dye loaded sensor FH@ZHY acts as a colorimetric as well as paper strip sensor for Cu2+. Fluorescence spectroscopic measurement shows that FH@ZHY exhibits high sensitivity and selectivity towards Cu2+ among various other metal ions in a EtOH/HEPES (1:1, v/v, pH = 7.2) solution. The behaviour of the sensor towards analyte detection was reversible with very low limit of detection. The sensing of Cu2+ ion
Bioisosterism based Design, Synthesis and Antifungal Evaluation of Novel Fluconazole Analogues
Authors: KANKATE RANI S. , NATHE VIKAS C. , KSHIRSAGER SANJAY J. , SURSE SUNITA N. , BHALERAO SNEHA A. , GHODKE SHANTANU S. , SADHWANI JATIN A.
Published: September 2023

A novel series of compounds containing tert.-amine moiety, piperazine triazole and triazole ring were synthesized by microwave assisted synthesis. The solubility and pharmacokinetic profiles of the compounds were improved by introducing the piperazine at the C3 position of fluconazole. The methylene bridge between the tert.-amine group and piperazine triazole moiety is kept constant. The tert.-amino moiety was chosen as a bioisostere to substitute tert.-alcohol group in fluconazole. In contrast to tert.-alcohols, tert.-amino groups exhibit the capacity to engage in hydrogen bonding interactions. Additionally, they have the ability to accept protons or form quaternary salts, thereby enhancing their water solubility. Furthermore, tert.-amino groups can coordinate with metal ions, potentially resulting in improved affinity, selectivity and potency in biological properties. In present study, homology models of the CYP51 enzymes derived from Candida albicans were developed using the X-ray crystal structure of CYP51 from Saccharomyces cerevisiae. These models were subsequently employed in a molecular docking investigation, focusing on the active site of the fungal enzymes responsible for lanosterol 14α- demethylation. The synthesized compounds were characterized using 1H NMR, IR and mass spectral techniques. The evaluation of compounds using the in vitro broth dilution technique and disc diffusion assay shown antifungal activity against C. albicans and C. tropicalis. The results indicated that certain compounds exhibited activity similar to that of fluconazole.
Introducing a novel and natural antibiotic for the treatment of oral pathogens: Abelmoschus esculentus green-formulated silver nanoparticles
Authors: Nie Tinghong , Liu Geng , Xiao Yunhe , Yari Hadis , Goorani Samaneh
Published: September 2023

Nanotechnology can solve many biomedical problems and cause transformation in the field of health and pharmaceuticals. The use of this technology in removing pathogenic bacteria is of great interest. The introduction of a strong antibacterial agent is very important to control pathogenic bacteria, especially strains resistant to antibiotics. The aim of this research was to synthesize silver nanoparticles (AgNPs) with the help of Abelmoschus esculentus aqueous extract and investigate its antibacterial properties against oral pathogens. Our study examined the ability of AgNPs to inhibit the dental bacterial growth and anti-adherence in vitro. The biosynthesized AgNPs@Abelmoschus esculentus were characterized by FT-IR, UV–Vis, and SEM tests. The physical and chemical investigation of the synthesized AgNPs showed that the particles were produced in nano dimensions, spherical shape, and without any impurities. In antibacterial test, the 8 µg/mL exhibited the lowest minimum inhibitory concentrations (MICs) against Porphyromonas gingivalis and Streptococcus mutans (MIC = 8 µg/mL). In vitro adherence of S. mutans was significantly prevented by AgNPs@Abelmoschus esculentus (MIC = 8–16 µg/mL). According to the results, the AgNPs@Abelmoschus esculentus may be good candidates for the oral hygiene agents to prevent periodontopathic conditions and dental caries.
Exploring Mutual Learning of Four Chinese Senior High School EFL Teachers in a Collaborative Action Research Community
Authors: Zheng Hongying , Huan Tingting
Published: September 2023

English as a Foreign Language (EFL) teachers’ professional development has been attached much importance with the advent of the National English Curriculum Standards (NECS in short) for Senior High Schools as it initiates the shift from knowledge-skill-oriented education to competence-oriented education. As an effective way for teachers’ professional development, collaborative action research community is introduced in this study to provide teachers with opportunities for mutual engagement, meaning negotiation, and a shared repertoire. Four senior high school EFL teachers from four different schools were studied in a collaborative action research community to explore how teachers from diversified backgrounds achieve mutual learning for their professional development. With data collected from observation, interviews, and journals, the study reveals that diversity and partiality help maintain mutual engagement in the community of practice. Meaning negotiation and mutual accountability in a joint enterprise contribute to the coherence of the community. Moreover, the participative activity of online and offline group discussion and the common topic of thinking visualization were treated as sources of a shared repertoire, an essential indication of a harmonious community. In this case, this study extrapolates how the collaborative action research community achieves harmony to support teachers’ professional development in action research.
Rebuilding Authority in “Lumpen” Communities: The Need for Basic Income to Foster Entitlement
Authors: Johnson Matthew Thomas
Published: September 2023

This article presents an immanent critique of neoliberal welfare reform using observation of participatory research involving left-behind communities in the North East of England and Australia. It argues that harms, such as passivity, invoked to reduce social security and increase conditionality are actually enhanced by austerity, conditionality and philanthropic giving. Deploying Mauss’ conception of the gift suggests that aggressive, conditional giving, combined with consumption through indebtedness, has served to strip individuals of authority. This leads to a radical conclusion: the stated aims of policy platforms like Big Society can only be realized through statutory entitlements like basic income.
Short Selling, COVID-19 and the Regulators – Lessons Learned
Authors: Sieder Sebastian
Published: September 2023

385Some national competent authorities (NCAs), as well as ESMA, have responded with short-selling bans and other restrictions to the COVID-19 pandemic. This approach has attracted criticism in both legal and economic literature. Although the COVID-19 pandemic has been overcome, or at least ways of dealing with COVID-19 have been found, it is of crucial importance for future EU short selling regulation how the legal basis of the measures for exceptional situations is designed and how the supervisory authorities will deal with it. This is valid not least because we are living in a time in which one crisis (COVID-19) follows the next (Ukraine war, gas shortage, inflation etc). Against this backdrop, this paper reviews the academic assessment of the supervisory approach taken and aims to contribute to an improved legislative and supervisory approach regarding short selling in (future) crises.386
Trial protocol: Feasibility of neuromodulation with connectivity-guided intermittent theta-burst stimulation for improving cognition in multiple sclerosis
Authors: Blanchard Caroline , De Dios Perez Blanca , Tindall Tierney , Clarkson Katie , Felmban Ghadah , Scheffler-Ansari Grit , Periam Roger , Lankappa Sudheer , Constantinescu Cris S. , das Nair Roshan , Morriss Richard , Evangelou Nikos , Auer Dorothee P. , Dineen Rob A.
Published: September 2023

Cognitive impairment in multiple sclerosis (MS) can adversely impact participation in employment, activities of daily living, and wider society. It affects 40–70% of people living with MS (pwMS). There are few effective treatments for cognitive impairment in people with MS. Neuromodulation with intermittent theta-burst stimulation (iTBS) has potential for treating cognitive impairment in pwMS. This single-centre mixed-methods feasibility randomised controlled trial (NCT04931953) will assess feasibility, acceptability, and tolerability of procedures used for applying iTBS for improving cognitive performance in pwMS. Participants will be randomised into three intervention groups with varying lengths of iTBS treatment (from 1 to 4 weeks) and a sham-control group. Quantitative data will be collected at three time points (baseline, end of intervention, and 8-week follow-up). End of the intervention semi-structured interviews will explore the views and experiences of the participants receiving the intervention, analysed using framework analysis. Quantitative and qualitative data will be synthesised to explore the impact of the iTBS intervention. Ethical approval has been received from the Health Research Authority (21/LO/0506) and recruitment started in June 2022. The results will inform the design of an RCT of the efficacy of iTBS as a therapeutic intervention for cognitive impairment in pwMS.
Synthesis, structure, and luminescence properties of double perovskites Ba2.9Sr0.1WO6: Eu3+ red emitting phosphor
Authors: Ullah Arif , Zhuang Jinghao , Liu Zheng , Yang Xiaozhan , Feng Wenlin
Published: September 2023

In this work, the phosphors of Eu3+ ions doped Ba2.9Sr0.1WO6 were successfully synthesized by the high-temperature solid-state method. The luminescence properties, including the emission and excitation spectra, fluorescent lifetimes, and CIE chromaticity coordinates were characterized. The crystal structure and composite of the samples were investigated by XRD (X-ray diffraction), and HRTEM (high-resolution transmission electron microscope). The emission spectra consist of the characteristic peak of Eu3+ excitation at 393 nm; the leading emission peak at 618 nm can be ascribed to the transition of 7F0 → 5L6. The optimal red emission is achieved by 2 % Eu3+ doping. This red Ba2.9Sr0.1WO6: Eu3+ has good luminescent properties and may have potential application in white LEDs.
Nuevos usos para viejas formas: el caso de cualmente en judeoespañol
Authors: García Moreno Aitor
Published: September 2023

Sephardic texts show a wide variety of adverbial forms ending in -mente, where the etymological scheme of adjective (fem.-sing.) + -mente has been broadened with formations such as verdadmente (‘truly’) or cercamente (‘closely’), in which the suffix -mente is attached (respectively) to a nominal and an adverbial base to form new adverbs of mode/manner. Now, the form cualmente deserves a whole new chapter. Thus, as it has been shown so far (García Moreno 2004, 264‒265, and Hernández González 2012, 196‒197, and 2018), this form of original adverbial character – with a similar meaning to that of its parallel talmente – shows in Judeo-Spanish a process of grammaticalization that has led it to function as a conjunction to introduce completive subordinate clauses.Having said that, such conjunctive uses – mainly documented in Sephardic texts of the so-called «rabbinical prose» of the 18th and 19th centuries – are practically absent in more modern texts. However, as we have demonstrated in this contribution, the form cualmente appears again reanalyzed in journalistic texts from the 1930 s as a type of a relative adverb with a value equivalent to that of ʻaccording to whichʼ and agglutinating the values +relative and +manner of their respective formants cual and -mente.
L’amore coniugale nella tradizione lirica femminile oitanica: persistenze e discontinuità nelle Autres Balades di Christine de Pizan1
Authors: Tornatore Lidia
Published: September 2023

Marital love is one of the major themes in medieval French literature. The paper aims to investigate this theme in Christine de Pizan’s heterogeneous collection of poems entitled Autres Balades. In particular, this contribution proposes a critical edition of two Ballads, namely No. 8 (Dieux! On se plaint trop durement) and No. 26 (Doulce chose est que mariage). The results of the study show the persistence of the theme in the female lyric tradition. Moreover, the resulting commentary reveals important influences of the Old French chansons de malmariée on Christine de Pizan’s Ballads.
Compressive Flow Behavior and Microstructural Evolution of Friction Stir Processed A356-5% B4C Composite
Authors: Gangolu S. , Sabirov I. , Gourav Rao A. , Prabhu N. , Kashyap B. P.
Published: September 2023

An Al-7Si-0.3Mg (A356) alloy reinforced with 5 % boron carbide (B4C) particulates was produced through squeeze casting technique at a temperature of 710°C. Friction stir processing (FSP) was employed on an A356-5% B4C composite with optimized parameters, viz., tool advancing speed of 15 mm/min and tool rotation speed of 250 r/min for one pass and two passes. High-temperature flow behavior of the FSPed A356-5% B4C composite was investigated by strain rate jump (1 × 10−3 to 5 × 10−1 s−1) compression tests using a thermomechanical simulator at temperatures of 470°C and 500°C. Strain rate jump tests revealed superplastic region with strain rate sensitivity index m = 0.4 in the lower strain rate regime of 1 × 10−3 to 5 × 10−2 s−1. However, the value of m reduced to 0.3 upon two-pass FSP. The reduction in m is attributed to the more uniform redistribution of hard Si particles throughout the composite, as examined by microstructure evolution in scanning electron microscopy, linked with energy-dispersive spectroscopy and electron-backscattered diffraction facility.
BANCO MUNDIAL E EDUCAÇÃO
Authors: Silva Ivanilso Santos da
Published: September 2023

Este trabalho discute o panorama da produção acadêmica sobre o Banco Mundial e Educação desde uma abordagem bibliométrica. Elegeu-se como fonte secundária de busca a base de dados Scopus. O banco de dados resultante da busca foi refinado em três etapas: a) análise dos títulos, b) número de citações e c) disponibilidade dos artigos para acesso gratuito, resultando num corpus N=56. A análise deu-se a partir de critérios de atividade científica dos autores, impacto das produções e associações temáticas, apoiando-se no processamento dos dados através do Software VOSviewer. Os resultados expressos em forma de distribuição cronológica, principais interrelações temáticas e identificação de redes de autoria e influência constituem-se em importantes contribuições deste estudo.
ANÁLISE ORTOGRÁFICA EM TEXTOS DO ENEM
Authors: Guimarães Daniela Mara Lima Oliveira , Couto Ana Luiza de Souza , Lacerda Luíza Vignoli
Published: September 2023

O objetivo deste artigo é identificar, categorizar e quantificar erros ortográficos em redações de candidatos ao Exame Nacional do Ensino Médio (Enem) de 2018. Como metodologia, foi utilizada a abordagem quali-quantitativa (PAIVA, 2019). O arcabouço teórico desta pesquisa foi pautado na Teoria da Integração de Múltiplos Padrões – IMP (TREIMAN; KESSLER, 2014; 2021). Como resultados, foram encontrados erros ortográficos nos níveis segmental e suprassegmental. Tais erros apontam para a necessidade de se trabalhar com a ortografia por meio de práticas didáticas sistematizadas e reflexivas que levam o aluno a refletir sobre a própria língua.
REFLEXÕES SOBRE A ESCRITA AUTORAL ACADÊMICA:
Authors: Barreto Dutra Leandro , Antonia Leonel de Moraes Martines Elizabeth
Published: September 2023

O objetivo é repensar a questão autoral nas produções acadêmicas e de nós mesmos e para tal fez-se uso da escrita ensaísta na política da narratividade. Foi produzido um conceito-abrigo temporário que se denominou de: antropofagia endossimbiótica baseando-se no conceito antropofágico social alinhavado à endossimbiose biológica. Espera-se ter acrescentado linhas no tecido teórico produzido junto à comunidade científica como também provocado outras reflexões para novas e pujantes pesquisas.
ENTRE A HISTÓRIA E A MEMÓRIA:
Authors: Fraga Pereira Franciele , Duarte Leon Adriana
Published: September 2023

O presente estudo analisa o Curso Técnico em Edificações, do IFSul Campus Jaguarão. A metodologia pautou-se na pesquisa qualitativa e utilizou da análise documental e do contato com os egressos para compreensão da problemática estabelecida. Os resultados do trabalho corroboram com a incumbência firmada entre instituto e comunidade local de formar profissionais sensíveis à temática do patrimônio cultural, demanda estabelecida pela população em audiências públicas prévias à instalação do Campus na cidade.
O ACERVO MEMÓRIA DOCUMENTAL DA CIDADE DE SÃO PAULO:
Authors: Bezerra de Souza Eduardo
Published: September 2023

O objetivo do artigo é problematizar o papel dos artefatos escolares na constituição da memória e identidade da escola paulistana. Toma-se como objeto o acervo histórico da Memória Documental, da Secretaria Municipal de Educação que mantém uma valiosa massa documental sobre a história da Educação da cidade de São Paulo desde a década de 1930. Os procedimentos metodológicos ancoram-se na História da Cultura Material. O provimento encontrado neste acervo emerge como patrimônio cultural, herança e memória de algo que se consolidou ao longo do tempo e que referencia a identidade da escola no município de São Paulo.
POR UMA INSTRUÇÃO PARA O PATRIMÔNIO:
Authors: Henrique da Silva Paes Pedro
Published: September 2023

A pesquisa objetiva-se discutir o lugar do Serviço do Patrimônio Histórico e Artístico Nacional (SPHAN) no Ministério da Educação e Saúde, salientando como o patrimônio poderia contribuir para as ideias educacionais vigentes entre 1937 e 1945. Buscamos pensar as ideias como constructos de sujeitos localizados em espaços de produção e sociabilidade do conhecimento. Assim, procuramos compreender o processo histórico da construção do projeto educacional do SPHAN e do projeto identitário do MES que foram alimentados conceitualmente do entendimento de Patrimônio e Educação a partir dos respectivos espaços de produção.
Central Asia Moves Beyond Russia
Authors: Engvall Johan
Published: September 2023

Russia’s invasion of Ukraine has backfired, weakening Moscow economically, politically, and militarily, and these setbacks have undermined Moscow’s strategic position in its so-called near abroad. Russia had considered Central Asia one of its most secure regions of influence, thanks to a multitude of linkages developed over a long period. But the war and its repercussions are altering Russia’s relations with its five former colonies in Central Asia, which are looking to end old dependencies and form alternative partnerships with other powers.
How Different Is The Status Of Depression And Anxiety In Patients With Rheumatoid Arthritis Receiving Methotrexate With Sulfasalazine Or Hydroxychloroquine?
Authors: Babaei Mansour , Dorparvar Mehdi , Ghahari Behnaz Yousef , Heidari Behzad , Gholinia Hemmat , Moudi Sussan
Published: September 2023

Background — Depression and anxiety are among the most common clinical manifestations in patients with rheumatoid arthritis (RA). Sulfasalazine and hydroxychloroquine are important medications used to treat these patients. Objective — The goal of this study was to compare the occurrence of depression and anxiety in RA patients taking sulfasalazine or hydroxychloroquine for at least six months. Methods — This study included 300 patients with RA referred to inpatient or outpatient departments of a public hospital in northern Iran who were treated with two combination regimens of methotrexate and sulfasalazine or methotrexate and hydroxychloroquine. Participants were assessed on the standard Hospital Anxiety and Depression Scale (HADS) for symptoms of depression and anxiety. Results — The mean HADS depression subscale score was 6.77±3.98 in the hydroxychloroquine group and 3.50±3.53 in the sulfasalazine group (p<0.001). The mean HADS anxiety subscale score was 7.66±4.43 in the hydroxychloroquine group and 5.34±4.35 in the sulfasalazine group (p<0.001). Multiple linear regression analysis revealed a significant difference in the incidence of depression and anxiety between the two treatment groups. Conclusion — A higher prevalence of depression and anxiety was observed in RA patients treated with methotrexate and hydroxychloroquine versus those treated with methotrexate with sulfasalazine.
Analysis of clinical effectiveness of hardware rehabilitation in patients with maxillofacial area pathologies (review)
Authors: Erokina Nadezhda L. , Lepilin Alexander V. , Raigorodsky Yuri M. , Bakhteeva Galiya R. , Rogatina Tatiana V. , Savelyeva Svetlana S.
Published: September 2023

Objective: to analyze the clinical effectiveness of apparatus rehabilitation in patients with maxillofacial pathology. Review writing methodology. The review of 15 publications is given in the article, where the results of research work of the employees of the Department of Dentistry of Surgical and Maxillofacial Surgery of V. I. Razumovsky Saratov State Medical University in the development of rehabilitation methods for patients with maxillofacial pathology during the period of thirty years (from 1995 to 2022) are presented. Employees of the Department of Dentistry of Surgical and Maxillofacial Surgery have substantiated the use of apparatus rehabilitation methods in the treatment of patients with the most widespread maxillofacial pathology. Conclusion. With the participation of staff of the Department of Dentistry of Surgical and Maxillofacial Surgery were created apparatus rehabilitation for physiotherapy, which meet the requirements of our time, which showed high efficiency in treating patients with the most common in the practice of the doctor's pathology of maxillofacial region. Patents for apparatus rehabilitation and methods of treatment of patients with head and neck diseases were received.
Dentists' and patients' opinion on the oncological examination of the lip, oral cavity and pharynx
Authors: Erugina Marina V. , Krom Irina L. , Sazanova Galina Y. , Balakina Diana D. , Arkhipov Denis O. , Nurieva Renata T.
Published: September 2023

Objective: to identify the features of oncological examination in dental practice. Material and methods. A survey of patients (n=417) and dentists of various specialties (n=402) was conducted to identify the practice and features of preventive oncological examination of the lips, oral cavity and pharynx. Results. When questioning, 50% of patients noted the incomplete implementation of various constituent elements of a comprehensive oncological examination of the lips, oral cavity and pharynx when visiting a dentist. When questioning dentists, it was revealed that 33% of respondents conduct oncological examinations. Conclusion. According to the results of a sociological study of patients and dentists, a discrepancy between the volume of preventive oncological examination of the lip, oral cavity and pharynx was revealed with the algorithm recommended by the World Health Organization. The Procedure for providing medical care to adults with dental diseases approved by the Ministry of Health of the Russian Federation regulates preventive examinations once every six months, but does not determine the purpose of the examination —the identification of visual forms of malignant neoplasms and precancerous diseases. The card of an outpatient dental patient (Form №043u) requires amendments regarding the inclusion of an algorithm for conducting oncological examination in it.
Assessment of the quality of life in peri- and postmenopausal women living in Yerevan based on Women's Health Questionnaire
Authors: Mirzoyan Lilia R. , Simonov Sergey N.
Published: September 2023

Objective: To assess the impact of peri- and postmenopause and some social-demographic and medical factors on scales of the quality of life (QoL) of women living in Yerevan. Material and methods. Across-sectional study was conducted among 353 women in the >40 age group. WHQ (Women Health Questionnaire) was used for the assessment of quality of life. Results. Negative indicators in peri- and postmenopausal women compared to women with a regular cycle were revealed on the scales "Vasomotor disorders" (0.46±0.05 and 0.51±0.03 vs. 0.17±0.03, p<0.001) and "Anxiety/fears" (0.40±0.04 and 0.38±0.02 vs. 0.27±0.03, p=0.013). The difference only between the groups of postmenopausal women and those with a regular cycle was registered on the scales "Somatic symptoms" (0.53±0.02 vs. 0.49±0.04, p=0.003), "Memory and concentration of attention" (0.47±0.03 vs. 0.39±0.04, p=0.015), Sexual Behavior (0.43±0.03 vs. 0.21±0.03, p<0.001) and "Attractiveness" (0.37±0.03 vs. 0.24±0.04, p=0.015). The presence of chronic diseases had a negative impact on QoL. From socio-demographic characteristics, negative was impact of age, low level of education, lack of employment, unfavorable family and financial status. Conclusions. There was a deterioration in all indicators of the QoL, except "Depressed mood", "Sleep problem", "Menstrual symptoms", in women of peri- and postmenopausal age. Age, low level of education, lack of employment, unfavorable family and financial status, the presence of chronic diseases had a negative impact on the QoL of the study participants.
Variability in size and shape of male and female sacrum in the middle and lower Volga regions
Authors: Peregoroda Sergey A. , Zaichenko Alexander A.
Published: September 2023

Objective: identification of variability in the size and shape of the sacrum of men and women of the Middle and Lower Volga regions. Material and methods. Macerated sacrums 21 men aged 18-75 and 21 women aged 22-85. Osteometry was performed according to the method of V. P. Alekseev. Results. In the sacrum of men, the sagittal diameter (by 3 mm, p<0.001) and width of the body of the first vertebra (by 4 mm, p=0.003), height (by 8 mm, p=0.006) and width (by 5 mm, p<0.001) predominate) ear-shaped surfaces, the lower width of the sacrum (by 7 mm, p=0.007). In the sacrums of women, the upper width of the pelvic surface (by 7 mm, p=0.008) and the sagittal diameter of the sacral canal (by 1 mm, p=0.007) predominate. The index of narrowing of the sacrum as a whole (63.8% in men, 58.5% in women) and the index of narrowing in the lower part (75.5% in men, 69% in women) demonstrate a high level of statistical significance of differences (by 5.3%, p=0.001, and 6.5%, p=0.008, respectively). Conclusion. The revealed variability in the size and shape of the sacrum of men and women of the Middle and Lower Volga regions lies in the large size of the body of the first vertebra and ear-shaped surface of the male sacrum, which is less narrowed in the lower part than the female one, while in women the sacrum has a greater degree of narrowing from top to bottom.
Continuous glucose monitoring in a patient with insulinoma presenting with unawareness of postprandial hypoglycemia
Authors: Nakajima Rikako , Idesawa Hiroto , Sato Daisuke , Ito Jun , Ito Kei , Fujii Masanao , Suzuki Takamichi , Furuta Tomoaki , Kawai Hitomi , Takayashiki Norio , Kurata Masanao , Yagyu Hiroaki
Published: September 2023

Unawareness of postprandial hypoglycemia for 5 years was identified in a 66-year-old man at a local clinic. The patient was referred to our hospital because of this first awareness of hypoglycemia (i.e. lightheadedness and impaired consciousness) developing after lunch. In a 75 g oral glucose tolerance test, the plasma glucose concentration was decreased to 32 mg/dL (1.8 mmol/L) at 150 min with relatively high concentrations of insulin (8.1 μU/mL), proinsulin (70.3 pmol/L), and C-peptide (4.63 ng/mL). In a prolonged fasting test, the plasma glucose concentration was decreased to 43 mg/dL (2.4 mmol/L) at 66 h with an insulin concentration of 1.4 μU/mL and a C-peptide concentration of 0.49 ng/mL. Computed tomography showed an 18 mm hyperenhancing tumor in the uncinate process of the pancreas. A selective arterial calcium stimulation test showed an elevated serum insulin concentration in the superior mesenteric artery. The patient was then diagnosed with insulinoma and received pancreaticoduodenectomy. Continuous glucose monitoring (CGM) using the Dexcom G6 system showed unawareness of hypoglycemia mainly during the daytime before surgery. When the sensor glucose value was reduced to 55 mg/dL (3.1 mmol/L), the Dexcom G6 system emitted an urgent low glucose alarm to the patient four times for 10 days. Two months after surgery, an overall increase in daily blood glucose concentrations and resolution of hypoglycemia were shown by CGM. We report a case of insulinoma with unawareness of postprandial hypoglycemia in the patient. The Dexcom G6 system was helpful for assessing preoperative hypoglycemia and for evaluating outcomes of treatment by surgery.

Learning points

Insulinoma occasionally leads to postprandial hypoglycemia.

The CGM system is useful for revealing the presence of unnoticed hypoglycemia and for evaluating treatment outcomes after surgical resection.

The Dexcom G6 system has an urgent low glucose alarm, making it particularly suitable for patients who are unaware of hypoglycemia.
The concept of “historical time” in modern liberal Islam: from the philosophy of temporality to the policy of memory
Authors: Kirchanov Maksym
Published: September 2023

In this article, the author examines the main features of the perception of historical time in the Arab, Iranian and Indonesian Muslim intellectual traditions in a comparative perspective. The purpose of the article is to analyze the images of "historical time" and its derivatives in the modern liberal segment of the Ummah. Therefore, the author analyzes 1) the peculiarities of the perception of historical time by liberal Muslim intellectuals, 2) the directions of assimilation of Western humanitarian methodology, 3) the prospects for transforming the perception of historical time in the modern humanitarian situation through the prism of rising interdisciplinarity. The article shows that 1) the liberal trend in the ummah demonstrates a wide range of perception of historical time, 2) historical time in Islam is perceived pluralistically, 3) the interpretation of historical time in liberal Islam is dependent on the cultural characteristics of the ummah. Methodologically, the article is based on the principles proposed in interdisciplinary historiography, proposed in intellectual history and new cultural history through the prism of imaginative and interventionist turns. The novelty of the study lies in the analysis of common and unique features of the perception of historical time and its derivatives by modern Muslim liberal intellectuals. The results of the study suggest that 1) Islam has become an important factor in the perception of "historical time", 2) the categories of “event history” and “historical progress” are reduced to the history of the progressive development and spread of Islam, 3) the transplantation of Western interdisciplinary epistemology has become an important factor in the invention of historical time. In general, the article shows that historical time is perceived as a symbolic space for localizing the key moments of the historical memory of the Muslim Ummah. The author believes that the imagination of historical time through the prism of modernity reduces history to the actual present, perceived in terms of the realization of the mission of Islam, associated with the achievement of its global dominance.
The Russian paradox of religion and fertility. Specification of the problem and development of an explanatory hypothesis
Authors: Zabaev Ivan , Kostrova Elizaveta
Published: September 2023

This article focuses on the specification of the hypothesis of the relationship between religiosity and fertility in Russia. On the surface, the situation looks like a paradox: (1) Churches and religions are generally known to support childbearing values; religious people are believed to have more children than non-religious people. (2) In Russia, however, religiosity has been growing in recent years, but fertility rates have been falling.Despite the fact that in contemporary Russia a large part of the population identifies with Orthodoxy and the number of such people is growing, family and marriage norms characteristic of Orthodoxy, in particular those related to the ideal of large families, are not actually being realized. This article proposes to consider mechanisms that might explain this circumstance. In order to specify the hypothesis of the potential influence of religion on fertility, a literature review was prepared, followed by the identification of key potentially important variables. Three approaches (and correspondingly three groups of texts) were identified that analyzed the relationship between religion and fertility: reduction of religion to individual religiosity; reduction of religion to a set of extra-religious variables; and analysis of religion as environment and community. Using the resources of the first two approaches does not allow us to formulate a hypothesis to explain today's Russian paradox of religion and fertility. It is possible to formulate an explanatory hypothesis based on the third class of texts. Kevin McQuillan's study is used to construct a hypothesis and to specify a vocabulary of variables about the Russian paradox. He identifies three aspects of the religious situation (pro-natalist doctrine, strong religious institutions, strong religious identity), which, in his opinion, can only work together to ensure that the principles preached by religion are actually realized. Based on the distinction made by C. McQuillan, as well as on the research of the third group of authors mentioned above, we show that contemporary Russian Orthodoxy cannot fully rely on any of these mechanisms of influence on believers, which, presumably, can explain the lack of an appropriate influence on their decisions in matters of family and marriage.
The phenomenon of drug addiction in the interpretation of the Russian Orthodox Church
Authors: Sosnina Anastasiya
Published: September 2023

Drug addiction is a complex spiritual, political, medical, social and legal problem. Trying to solve it, the state is developed an anti-drug policy that includes a possibility for religious organizations to participate in the prevention of non-medical drug use and the rehabilitation of drug addicts. In 2012 the Church approved a document “On the participation of the Russian Orthodox Church in the rehabilitation of drug addicts” and actively developing social work. The Decree of the President of the Russian Federation "On the Approval of the Strategy of the State Anti-Drug Policy of the Russian Federation for the period until 2030" calls on religious organizations to develop a position that will enrich the anti-drug ideology according to "traditional values" . This calls the Church the task of developing a theological argument about the dangers of drug use. In this regard, it seems relevant to analyze the theoretical and practical developments of the ROC in this area. The author of the article asks the questions: What are the legal and theological grounds for the ROC's approach to the problem of drug addiction? What anthropological ideas are used to describe the phenomenon of drug addiction? The first part of the article presents a systematization of theoretical ideas related to the topic of drug addiction, reflected in the church regulations of the ROC. The second part presents an analysis of the opinions of clergy and lay practitioners. The author comes to the conclusion that by developing its own approach, the Church remains in the field of the political, medical, legal aspects of the problem, which leads to the ideologization of the language in which the Church speaks about the problem.
On stability estimations without any conditions of symmetry
Authors: Januškevičius Romanas , Januškevičienė Olga
Published: September 2023

Let X, X1, X2, ..., Xn be i.i.d. random variables. B. Ramachandran and C.R. Rao have proved that if distributions of sample mean ‾X = ‾X(n) = (X1 + ⋯ + Xn)/n and monomial X are coincident at least at two points n = j1 and n = j2 such that log j1/ log j2 is irrational, then X follows a Cauchy law. Assuming that condition of coincidence of \bar X(n) and X are fulfilled at least for two n values, but only approximately, with some error ε in metric λ, we prove (without any conditions of symmetry) that, in certain sense, characteristic function of X is close to the characteristic function of the Cauchy distribution.
Effect of COVID-19 Pandemic on Hepatocellular Carcinoma Diagnosis: Results from a Single Turkey Center Study
Authors: Bilican Gülden , Özgül Seçkin , Ekmen Nergiz , Moral Kenan , Küçük Harun , Dumanlı Serkan , Abiyev Azer , Karakan Tarkan , Kekilli Murat
Published: September 2023

Background and Aims: Currently malignancies of the liver are the sixth most frequently diagnosed cancers worldwide. The admission of patients to hospitals decreased due to the restriction of the Coronavirus disease 2019 (COVİD-19) pandemic, especially patients suspected with cancer were delayed in their diagnosis and treatment. With this study, we aimed to investigate whether the Covid-19 pandemic caused a decrease in the number of hepatocellular cancers (HCC) or a delay in its diagnosis.

Methods: The study, which included newly diagnosed HCC patients, was conducted as a retrospective cross sectional study, in a single Turkey medical center. The patients were divided into pre-COVID-19 and post- COVID-19 two-year periods and compared in terms of tumor size, biochemical parameters, clinical and demographic features.

Results: A total of 63 HCC patients, 46 (73%) patients before the COVID-19 pandemic and 17 (27%) patients diagnosed during the COVID-19 pandemic were included. Maximum diameter of lesions and serum alpha- fetoprotein levels showed a statistically significant difference between the groups. Maximum tumor size in the pre-COVID-19 period was 4.58±3.77 mm, while in the COVID-19 period was 7.42±6.88 mm, the difference between two groups being statistically significant (p<0.05). HCC in the pre-COVID-19 period were detected mostly at Barcelona Clinic for Liver Cancer (BCLC) stage A (45.7%, n=21), while in the COVID-19 period most of HCC were detected at stage B (35.3%, n=6).

Conclusions: The COVID-19 pandemic limited the access of patients to screening programs for HCC. The significant disruption in screening cirrhotic patients for HCC has led to a delay in diagnosis.
Frequency and Related Risk Factors of Refeeding Hypophosphatemia in Patients with Liver Cirrhosis: A Pilot Study
Authors: Can Sezgin Gulten , Ozer Nurhayat Tugra , Sahin Gulsah Gunes , Sahin Serap , Yurci Mustafa Alper , Guven Kadri , Gundogan Kursat
Published: September 2023

Background and Aim: Refeeding hypophosphatemia (RH) is associated with poor clinical outcomes and mortality. The presence of RH in patients with liver cirrhosis remains unclear. This study aims to determine the frequency of RH related to nutritional status and disease severity in liver cirrhosis.

Methods: This study was prospectively conducted in a-single center gastroenterology clinic. Malnutrition was identified by Subjective Global Assessment (SGA). The disease severity was defined using Child score and MELD score. Serum phosphate levels <2.0 mg/dl are defined as hypophosphatemia.

Results: Twelve of 50 cirrhotic patients (24%) had RH during hospitalization. The most common RH was determined in 4 patients on day 4 during study follow up. The sharpest decline of serum phosphate levels was on day 4 (median: 2.3mg/dL). The Child score and MELD score were not significantly different between RH and Non-RH groups (p>0.05). The rate of malnutrition according to SGA was 56.0%. A total of 82%, 4%, 8%, and 4% of participants received regular diet and oral nutritional supplements, only enteral tube feeding, only parenteral nutrition, and combined enteral and parenteral nutrition, respectively. In the RH group, 32% of participants received only parenteral nutrition and had a higher presence of RH than patients receiving only oral or enteral tube feding (p<0.05).

Conclusions: RH developed in ¼ of the study participants. This study also showed that artificial feeding carries a significant risk in terms of RH. Malnourished patients with liver cirrhosis receiving parenteral nutrition, closely monitored regarding high risk of RH.
The impact of artificial intelligence on modern education: prospects and challenges
Authors:   Cherkasy State Technological University, Ukraine, A Nykonenko
Published: September 2023

This paper examines the intricate links between artificial intelligence (AI) and education, delving into both theoretical and practical aspects while evaluating possible ramifications for labor market dynamics, professional activity, and wider educational paradigms. Our research methodology involved analyzing relevant scientific literature, classifying data, consulting with subject matter experts, and synthesizing the results. Our research suggests that AI has the ability to greatly improve pedagogical processes, personalize learning experiences to meet individual student needs, and successfully address the time and financial limitations that are inherent in traditional educational models. However, our study also reveals challenges related to data confidentiality, potential plagiarism and fraud associated with AI use, and socioeconomic disparities resulting from unequal technology access. Additionally, we identified a significant gap in current AI usage standards legislation. It is essential for researchers, educators, and policymakers to recognize the potential risks of AI implementation in educational settings and proactively develop strategies that prioritize ethics, safety, and effectiveness. With labor market trends favoring specialists knowledgeable in utilizing AI tools, a consequent change in curricula is expected. In response to our findings, we recommend the creation of new academic disciplines that concentrate on the cultivation of AI expertise; the establishment of comprehensive national AI strategies; the crafting of retraining roadmaps for those who may be affected by AI automation; the inclusion of online AI courses in existing educational programs; and the promotion of grant funding for future AI research. Our future research will concentrate on reducing the potential negative impacts of integrating AI into educational systems.
Establishing Rapport with the Reader: Engagement Markers in the Discussion Section of a Research Article
Authors: Tikhonova Elena V. , Kosycheva Marina A. , Golechkova Tatiana Yu.
Published: September 2023

Introduction. The paper studies the use of engagement markers in discussion sections of English-medium research articles in medical and foreign language teaching domains by two groups of academic writers, Anglophone and non-native ones using English as a Lingua Franca.
Materials and Methods. In order to explore how disciplinary considerations and author language backgrounds affect the choice, frequency and distribution of engagement markers, we built a corpus of 68 research papers (34 medical and 34 EFL papers) published in international and national academic journals between 2019 and 2022. The markers were investigated using contrastive analysis applying Hyland & Jiang’s modified model.
Results. Corpus analysis stressed both cross-disciplinary and language distinctions. The analysed foreign language teaching research papers rely on engagement more than the medical papers, which is manifested in the frequency of the use of markers. Writers in both disciplines engage with the reader through reader mentions and appeals to shared knowledge, but unlike medical papers, teaching ones rely heavily on managing the readers’ attention and addressing them directly through asides. From the linguacultural perspective, Anglophone writers use engagement markers a little more frequently than the authors from non-English-speaking countries. The main distinction lies in direct addresses to the reader which are realised in personal asides and questions. Overall, Anglophone writers tend to use a broader variety of engagement markers than non-Anglophone authors. The frequency and selection of engagement markers are influenced by language background, reflecting differences in linguistic-cultural conventions, target audiences, and publication contexts. Within the global scientific community, it is crucial to investigate how multilingual authors navigate the use of metadiscourse markers. Native English speakers and non-native speakers engage in a dialogue as equals, disregarding linguistic dominance. This highlights the need for unified conventions in establishing a global academic lingua franca.
Discussion and Conclusion. The findings of this study hold significant pedagogical implications, providing support for academic writers and promoting the development of a global academic language and culture. By understanding the dynamics of engagement markers and their role in effective communication, pedagogical efforts can focus on enhancing global academic language skills and fostering a cohesive global academic culture.