bluuebunny/crossref_metadata_2025 huggingface dataset:
Thermodynamic Stability and Anion Ordering of Perovskite Oxynitrides
Authors: Young Samuel , Chen Jiadong , Sun Wenhao , Goldsmith Bryan , Pilania Ghanshyam
Published: April 2023

Perovskite oxynitrides (PONs) are a promising class of materials for applications ranging from catalysis to photovoltaics. However, the vast space of single PON materials (ABO3–xNx}) has yet to be fully explored. Additionally, the community needs guidelines that relate PON chemistry and anion ordering to stability to better understand how to design PON materials that resist corrosion and decomposition under operating conditions. Screening this materials space requires identifying candidate PON materials that will be stable under operating conditions, which in turn requires methods to evaluate each material's stability. Here we predict the stability of single PON materials using a four-step approach based on density functional theory modeling: (I) enumerate viable cation pairs, (ii) select an energetically favorable prototypical anion ordering, (iii) compute each PON's free energy above the thermodynamic convex hull, and (iv) generate computational Pourbaix diagrams to determine allowable ranges of electrochemical operating conditions. A critical part of our approach is determining a prototypical stable anion ordering for both ABO2N and ABON2 stoichiometries across a variety of A- and B-site cations. We demonstrate a stable anion ordering containing a high degree of cis ordering between B cations and minority-composition anions. We predict 85 stable and 109 metastable PON compounds, with A∈{La, Pb, Nd, Sr, Ba, Ca} and B∈{Re, Os, Nb, Ta} forming cation pairs that lead to stable PONs less than 10 meV/atom above the thermodynamic convex hull. Computational Pourbaix diagrams for two stable candidates, CaReO2N and LaTaON2, suggest that not all compounds with zero energy above the thermodynamic convex hull can be easily synthesized.
Accurate computation of thermodynamic activation parameters in the chorismate mutase reaction from empirical valence bond simulations
Authors: Wilkins Ryan S , Lund Bjarte A , Isaksen Geir V , Åqvist Johan , Brandsdal Bjørn O
Published: April 2023

Chorismate mutase enzymes have long served as model systems for benchmarking new methods and tools in computational chemistry. Despite the enzymes’ prominence in literature, the extent of the roles activation enthalpy and entropy play in catalyzing the conversion of chorismite to prephenate is still subject to debate. Knowledge of these parameters is a key piece in fully understanding the mechanism of chorismite mutases. Within this study, we utilize EVB/MD free energy perturbations at a range of temperatures, allowing us to extract activation enthalpies and entropies from an Arrhenius plot of reaction free energies of the reaction catalyzed by a monofunctional Bacillus subtilis chorismate mutase and the promiscuous enzyme isochorismate pyruvate lyase of Pseudomonas aeruginosa. In comparison to the uncatalyzed reaction, our results show that both enzyme-catalyzed reactions exhibit a substantial reduction in activation enthalpy, while the effect on activation entropy is relatively minor, demonstrating that enzyme-catalyzed chorismate mutase reactions are enthalpically-driven. Furthermore, we observe that the monofunctional chorismate mutase from B. subtilis more efficiently catalyzes this reaction than its promiscuous counterpart. This is supported by a structural analysis of the reaction pathway at the transition state, from which we identified key residues explaining the enthalpically-driven nature of the reactions, and also the difference in efficiencies between the two enzymes.
Experimental Investigation on Thermophysical and Stability Properties of TiO2/Virgin Coconut Oil Nanofluid
Authors: Oemar Barlin , Arifin Amir , Bahrin David , Astuti Astuti , Ramadhan Dwiki , Rifqy Muhammad Abil , Tinambunan Muhammad Reza
Published: April 2023

This paper shows experimental study results on the thermophysical and stability of nanofluids of Titanium oxide (TiO2) dispersed in high-purity of Virgin Coconut Oil (VCO). Nanofluid samples that functioned as a lubricant were prepared by a two-step preparation method at different volume fractions (0.1, 0.3, and 0.5 vol.%) and different temperatures (28, 40, and 100°C). The dynamic viscosity and density were performed using Falling Ball Viscometer and Pycnometer, respectively. The sedimentation photograph method using a digital camera was applied to analyze the stability. A maximum dynamic viscosity enhancement of 62.78% was recorded for TiO2/VCO nanofluid with 0.5% nanoparticle volume fraction and at the temperature of 100°C). Whereas, the highest density improvement was recorded for TiO2/VCO nanofluid with 0.5% nanoparticle volume fraction. Freshly prepared nanofluids did not show any significant change in stability. However, a trivial phase separation appeared in the samples after 8 days. The results indicated that adding TiO2 nanoparticles increased the dynamic viscosity and density. It can be concluded that the volume in fraction has the effect to enhance the thermophysical stability of TiO2/VCO nanofluids.
Bi-Univalent Function Classes Defined by Using an Einstein Function and a New Generalised Operator
Authors: Rossdy Munirah , Omar Rashidah , Soh Shaharuddin Cik
Published: April 2023

Let A be the class of all analytic and univalent functions f (z) = z+Σ∞k=2 akzk in the open unit disc D = {z:|z|<1 }. S then represents the classes of every function in A that is univalent in D. For every f ∈ S, there is an inverse f−1. A function f ∈ A in D is categorised as bi-univalent if f and its inverse g = f−1 are both univalent. Motivated by the generalised operator, subordination principle, and the first Einstein function, we present a new family of bi-univalent analytic functions on the open unit disc of the complex plane. The functions contained in the subclasses are used to account for the initial coefficient estimate of |a2|. In this study, we derive the results for the covering theorem, distortion theorem, rotation theorem, growth theorem, and the convexity radius for functions of the class Ns,m,kλ,α (Σ, E) of bi-univalent functions related to an Einstein function and a generalised differential operator Ds,m,kλ,α f (z). We use the elementary transformations that preserve the class Ns,m,kλ,α (Σ, E) in order to attain the intended results. The required properties
Perturbed Trapezoid Like Inequalities
Authors: Alshanti Waseem Ghazi , Batiha Iqbal Mohammad , Alshanty Ahmad , Zraiqat Amjed , Jebril Iqbal Hamzah , Abu Ma’mon Ahmad
Published: April 2023

In our current research article, based on a general configuration of a 3-step Peano kernel, new versions of integral inequality of Ostrowski’s type are developed for differentiable mappings that have second derivatives belong to L∞. Then we utilized these versions to generate new perturbed trapezoid like inequalities. These new perturbed trapezoid like inequalities are proposed with error bounds smaller than and similar to those reported by previous studies. Moreover, some of the obtained perturbed trapezoid like inequalities reveal the relationship between the Euler-Maclaurin summation and the trapezoidal rule. Finally, certain implementations to numerical composite quadrature rules are provided for completeness.
Isolation of Cellulase from Selected Fungal Strains and Its Use for Manufacture Microcrystal Cellulose from Kapuk Cortex (Ceiba Pentandra (L.) Gaertn)
Authors: Mi'rajunnisa Mi'rajunnisa , Suryadi Herman , Sutriyo Sutriyo , Lestari Yulianita Pratiwi Indah
Published: April 2023

This study aims to obtain cellulase enzymes from selected molds for microcrystalline cellulose preparation from ????-cellulose of kapok cortex. Alpha-cellulose was obtained by biodelignification, and the purified cellulase was obtained from the selected mold. The Microcrystalline cellulose obtained from enzymatic hydrolysis was then identified FTIR and DSC, followed by characterization of microcrystalline cellulose, Particle Size and Distribution Analysis (PSA), and Scanning Electron Microscope-Energy Dispersive X-ray (SEM-EDX), Loss on drying, pH, bulk density, tapped density, and flow rate. Biodelignification produced 14.88% ????-cellulose, Penicillium sp. the selected mold had the highest cellulase activity, with a cellulolytic index of 4.83. FTIR identification was similar to Avicel PH 101 with a melting point of 244.580°C. Loss on drying was 3.74%, pH was 7.0, particle size ranged from 13.06 to 196.79 ????m, bulk density and tapped density were 0.11 g/cm3 and 0.23 g/cm3, respectively flow rate character is quite good. SEM-EDX was showed that the morphological shape of the microcrystalline cellulose of the kapok cortex is elongated. Microcrystalline cellulose has shown a quite similar in character and can be furthered.
Drought Assessment in Aceh and North Sumatra Using Effective Drought Index
Authors: Suhadi Suhadi , Supari Supari , Iskandar Iskhaq , Irfan Muhammad , Akhsan Hamdi
Published: April 2023

Indonesia has two seasons and witnesses three rainfall patterns throughout the year. Although Aceh and North Sumatra experience low rainfall, the underlying causes of this condition are unknown. Unfortunately, studies on drought in these regions are very limited. This study uses the Effective Drought Index (EDI) to assess drought in these regions using daily rainfall data from 1985–2019 (35 years) from the meteorology, climatology, and geophysics agency stations. These stations are Sultan Iskandar Muda, Malikussaleh, Deli Serdang, and FL Tobing. In this study, the Ocean Niño Index (ONI) and the Dipole Mode Index (DMI) were used to identify El Niño years and positive and negative phases of the Indian Ocean Dipole (IOD). These indices were used to analyze drought-related climatic phenomena. The results obtained indicated that some drought events were not associated with a positive Indian Ocean Dipole or El Niño, as is typically the case. These include the extreme drought in 1989/90 and moderate drought in 1999 at Sultan Iskandar Muda, moderate drought at Malikussaleh (March to June 2008), moderate drought at Deli Serdang in 2010, as well as the drought from January to June 2006 at FL Tobing. Analysis of spatial patterns revealed that moderate droughts were more prevalent than severe and extreme droughts. These drought assessment results are essential for the mitigation of natural catastrophes.
Accidents and poisoning caused by arachnids on domestic felines and canines: a review
Authors: Lucena Raíssa Coutinho de , DaSilva Marcio Bernardino
Published: April 2023

Poisoning by spiders' bites and scorpions' stings domestic canines and felines seems to be frequent, considering the biology and behavior of these animals. However, little is known about this relationship. In the present review, we compiled the available information concerning this topic by focusing on arachnids that can cause accidents, reported cases in the scientific literature, and epidemiological and clinical aspects of accidents with domestic canines and felines. Arachnids of medical importance are distributed worldwide, but the cases described in the literature are episodic, and some report animals' death. Each taxon has specific venom toxicity that can affect organisms differently. Thus, the diagnosis and clinical treatment must be based on the individual that caused the accident. Knowledge on the occurrence of arachnids of medical importance, their biology, and venom toxicity must be deepened and publicized to avoid accidents.
Research Progress of Traditional Chinese and Western Medicine Dressing Change on Wound Healing After Anal Fistula Surgery
Authors: Miao Xiaona , Hang Jia-min
Published: April 2023

With the change of people’s lifestyle and diet, the incidence of anorectal diseases is increasing year by year. Anal fistula is a common anorectal disease. Because it cannot heal by itself, surgery has become the main treatment method. Due to the particularity of wound location and physiological structure, the wound is easily contaminated by bacteria, so dressing change after surgery plays a decisive role in wound healing. Modern western medicine and traditional Chinese medicine have different dressing changing methods respectively. In this paper, we reviewed commonly used dressing changing methods of traditional Chinese and western medicine after anal fistula surgery.
Kajian Kritis Eksistensialisme pada Kaidah Penafsiran Salaf dalam Kitab Qawāid At-Tafsir Jam’an Wa Dirāsatan
Authors: - Hilyati Aulia
Published: April 2023

Kaidah tafsir tidak dapat dipisahkan dari tafsir al-Quran. Tafsir al-Quran selalu berhubungan dengan konteks yang menaungi sebuah masyarakat. Kaidah tafsir mempunyai urgensi wajib dipelajari agar seorang mufassir tidak jatuh pada kesalahan dalam penafsiran. tetapi seringkali terdapat kaidah-kaidah yang mendapatkan klaim secara sepihak bahwa pendapat ulama salaf wajib diikuti tanpa membaca keterangan kaidah itu lebih lanjut. Klaim sepihak ini dan pengetahuan yang hanya sekilas dan sifatnya terbatas kulit saja yang kemudian membuat hasil tafsir terperangkap dalam absolutisme. Artikel ini bertujuan untuk mengetahui semangat eksistensialisme menurut Nietzche dan bagaimana kandungan eksistensialisme pada kaidah penafsiran salaf dalam kitab Qawaid at-Tafsir Jam’an wa Dirasatan. Artikel ini termasuk jenis penelitian kualitatif dengan menggunakan pendekatan library research dengan menggunakan teori Eksistensialisme Nietzche. Subjek dari penelitian ini adalah kaidah-kaidah penafsiran salaf dalam kitab Qawaid at-Tafsir Jam’an wa Dirasatan. Data akan dikumpulkan menggunakan teknik dokumentasi dan data akan diolah menggunakan systematic literature review. Hasil dari penelitian ini adalah Ketiga kaidah penafsiran salaf dalam Kitab Qawaid at-Tafsir Jam’an wa Dirasatan secara tersirat mengindikasikan adanya semangat eksistensialisme. Semangat eksistensialisme meliputi dua hal yaitu menolak absolutisme dan membangkitkan kreatifitas berfikir secara mendalam. Kritik yang dilakukan oleh penulis adalah kritik yang bersifat membangun (konstruktif).
ისა ნეჯათი ბეის თეზქერე
Authors: KAHIA Alkazar Aleko , TANDİLAVA Lile
Published: April 2023

შუა საუკუნეების თურქული დივანის ლიტერატურის უმნიშვნელოვანესი წარმომადგენელის, რომელმაც ახალი სიცოხლე შთაჰბერა კანონუკურ და „იგივეობის ესთეთიკაზე“ განპირობებულ მხატვრულ აზროვნებას - ისა ნეჯათი ბეის ლირიკამ თავიდანვე მიიპყრო იმ ჟამინდელი პოეზიის აუცილებლობით შეპყრობილი არისტოკრატიის ყურადღება და თეზქერეჯიების მუდმივი განჭვრეტვის ობიექტად იქცა. ნეჯათის ჩვენამდე მოღწეულ ნაწარმოებთაგან ერთადერთი მისი დივანია, რომელიც თეზქერეჯი მუეიედზადზე აბდურრაჰმან ჩელებიმ შეადგინა. პოეტის სამწერლობო ენა, განსაკუთრებით მის ყაზელებში, არის სადა, მარტივი და მსუბუქი. მისი პოეტური სტილი კი ძლიერი და შთაბეჭდავია. იგი ხალხური სიბრძნის წიაღიდან მომდინარეობს და ახლოს დგას მის ფსიქოლოგიასთან. განსაკუთრებით ბუნებისა და ნადირობის სცენების აღწერისას, მკაფიოდ იგრძნობა ადგილობრივ, ნაციონალურ ფერთა სიკაშკაშე, რომელიც დაცლილია არაბუნებრივი, თავსმოხვეული გრადაციებისაგან და აღსავსეა ცხოველი შეგრძნებებით. მისი პოეტური ენის მუსიკალურობა, თითქოს უჩუმრად მონატრებული ჰანგი იყო უკვე მონოლითად ქცეულ, მომოტონურად მჟღერ კანონიკურ პოეზიაში, ამიტომაც იგი სწრაფად მიწვდა ყველანაირი სოციუმის ყურს, ასეთივე დამახასიათებელი სემანტიკით კი ნებისმიერ სოციალურ საფეხურზე მდგომის გულსა და გონებას და ამიტომაც დიდხანს შემორჩა მის მეხსიერებაშიც. მე-15 საუკუნის სასაუბრო ენის დივანის პოეზიაში აჟღერება, ანდაზებისა და ხალხური გამონათქვამების გამოყენება, ხალხური მეტაფორებისა და შედარებების თავისუფალი გადმოცემა, კაფიესა და რედიფის თურქული სიტყვებით შერჩევა, თურქული არუზის დამკვიდრება, ეს ის ნაპერწკლებია ნეჯათის მიერ ანთებული, რომელზეც გაჩაღდა მე-20 საუკუნის ლიტერატურული რევოლუცია. ნეჯათის სალიტერატურო ენა იქცასინთეზად თურქული ხალხური და კლასიკური ენებისა და ცალკე მოვლენად თურქულ პოეზიაში, რომელსაც იყენებდნენ და ბაძავდნენ შემდეგი თაობების პოეტები. ნეჯათი ბეის დივანის არქიტექტონიკია არ დაურღვევია, პირიქით, მან შეავსო ის წყვეტა -სიცარიელე, რომელიც ხლეჩდა და ორ პოლუსზე აყენებდა ერთი კულტურის ორ ლიტერატურას - ხალხურსა და კლასიკურს. შეიძლება ითქვას, მან პირველმა შეძლო გაბედვა ასწლეულებით ნატკეპნი დივანისათვის ახალი სული შთაებერა, რაც მომავალი თაობების ლირიკული აზროვნების შთაგონებად იქცა. მან შეძლო მისი პოეზია სასახლის დიდებულებას გასცლოდა და ბაზრებსა თუ ვიწრო ქუჩა-ბანდებშიც აჟღერებულიყო. ნეჯათი თავის სიცოცხლეშივე იქცა პოეზიის დიდოსტატად და მის ლირიკულ სტილსა და პოეტურ ენას თავიდანვე გამოუჩდნენ მიმდევრები. პოეტი პოეზიაზე და სხვა პოეტებზე თავის ერთ-ერთ ბეითში წერდა: „როგორც შაქრის ლერწამი კალმის დარად სტრიქონს ვერ დაწერს, ისე განცხრომასა და სიხარბეს მიცემული ხელოვანი სიტყვას ვერ განადიდებს, ამიტომაც, ამა ქვეყნის სიამენი სხვა რამეა, ლექსის წერა კი, სხვაგვარი.“
The role of polymorphism of candidate genes in the development of knee osteoarthritis in men of the Central Chernozem region of Russia
Authors: Novakov V. B. , Novakova O. N. , Churnosov M. I.
Published: April 2023

Knee osteoarthritis (OA) is a disease resulting from the interaction of many local and systemic risk factors, among which an important role is played by genetic (hereditary) factors. This disease affects both men and women, but there are certain differences in the development and progression of the disease in different sexes.

Aim. To study associations of polymorphic loci of candidate genes with the risk of developing knee ОА in the male population of the Central Chernozem region of Russia.

Material and Methods. The study sample included 410 men (208 patients with knee OA and 202 controls). Ten polymorphic loci of candidate genes were genotyped: rs2820436 and rs2820443 LYPLAL1, rs3771501 TGFA, rs11177 GNL3, rs6976 GLT8D1, rs1060105 and rs56116847 SBNO1, rs6499244 NFAT5, rs34195470 WWP2, rs143384 GDF5. The study of associations of polymorphic genetic loci with the development of the disease was carried out by the method of logistic regression, taking into account covariates (age, BMI). The MB-MDR method was used to study intergenic interactions of polymorphisms associated with the disease.

Results and Discussion. It was found that nine out of ten polymorphic loci of candidate genes (with the exception of rs6976 GLT8D1) are associated with the formation of knee OA in men in four models of interlocus interactions (pperm ≤0.024). The rs3771501 TGFA polymorphic locus (included in three of the four most significant models of gene-gene interactions) demon- strates the greatest contribution to the development of the disease in men. Independent effects of the studied polymorphic loci of candidate genes in the development of knee OA in men have not been identified (р > 0,05).

Conclusion. Polymorphic loci rs2820436 and rs2820443 LYPLAL1, rs3771501 TGFA, rs11177 GNL3, rs6976 GLT8D1, rs1060105 and rs56116847 SBNO1, rs6499244 NFAT5, rs34195470 WWP2, rs143384 GDF5 involved in the development of knee osteoarthritis in men in four models of intergenic interactions. Among the studied loci, rs3771501 of the TGFA gene has the greatest contribution to disease susceptibility.
Dış doğrultu ölçmeleriyle geriden kestirmede Collins ve Akarsu yöntemleri
Authors: AKARSU Veli
Published: April 2023

Yeryuvarında tanımlanmış olan bir iki boyutlu (2B) dik koordinat sisteminde, koordinatı bilinmeyen noktadan (doğrultu ölçmeleri yapılan nokta) koordinatları bilinen (en az dört nokta) noktalara, en az iki tam dizi doğrultu ölçmelerinde hesaplanan düzlem açılar ile koordinatların hesaplanmasına geriden kestirme problemi denir. Bir, iki, üç veya çok noktanın koordinatları geriden kestirme yöntemiyle hesaplanabilmektedir. Günümüzde kullanılan geriden kestirme yöntemleri: Collins, Kaestner, Delambre, Cassini, Ansermet ve Akarsu yöntemleridir. Bir alıcı ile küresel konum belirleme sistemleri ile nokta konum koordinatlarının belirlenmesi, geriden kestirme yöntemine dayanması nedeniyle daha da önemli hale gelmiştir. Bu çalışmada, geriden kestirme noktasındaki dış açılar ile geriden kestirme probleminin çözümü, Collins ve Akarsu yöntemleri ile çözümünün teorik açıklamaları yapılmıştır. Ayrıca, sayısal bir uygulama ile de Collins yöntemiyle hesaplanan kestirme noktasının kesin koordinatlarına ait standart sapmaları;
σ_x^C=∓2,7 mm ,σ_y^C=∓11,4 mm ve Akarsu çözüm yönteminde ise ise; σ_x^A=∓1,4 mm ,σ_y^A=∓1,2 mm değerleri elde edilmiştir. Her iki çözüm yöntemiyle elde edilen değerler, bulgular ve tartışma bölümünde yorumlanmıştır.
Simultaneous surgical correction of stress urinary intention and erectile dysfunction after surgical treatment of prostate cancer.
Authors:   Center for Urology and Andrology, Federal State Budgetary Institution State Research Center of the Federal Medical and Biological Center named after A.I. Burnazyan FMBA of Russia, Kyzlasov P.S. ,   Moscow, Russia, Filimonov V.B. ,   department of urology with a course of surgical diseases Ryazan state medical university named after acad. I.P. Pavlov, Ryazan, Russia, Vasin R.V. ,   department of urology with a course of surgical diseases Ryazan state medical university named after acad. I.P. Pavlov, Ryazan, Russia, Sobennikov I.S. ,   department of urology with a course of surgical diseases Ryazan state medical university named after acad. I.P. Pavlov; Ryazan, Russia, Petryaev A.V. ,   department of urology Tula regional clinical hospital; Tula, Russia
Published: April 2023

Introduction. Urinary incontinence and erectile dysfunction are common consequences of radical prostatectomy, which may require surgical correction. The article presents the results of simultaneous implantation of a suburethral sling and a penile prosthesis from one access in a patient after radical prostatectomy. Clinical case. A 63-year-old patient, 13 months after radical prostatectomy (without preservation of neurovascular bundles) for prostate cancer pT2cN0M0 underwent simultaneous installation of a male sling and a semi-rigid phaloprosthesis from the perineal access. Results and discussion. The duration of the surgery was 1 h 5 min. There were no complications during the surgery. The postoperative course was uneventful. The patient was discharged on the 6th day after the surgery. During the control examination 2 months after the operation, good cosmetic and functional results were noted. Conclusions. Simultaneous implantation of a suburethral sling and a phaloprosthesis may be an effective way to eliminate the functional consequences of urinary incontinence and erectile dysfunction after radical prostatectomy, not accompanied by an increase in the risk of complications.
MULTIGENE GERMLINE NGS TESTING IN TRIPLENEGATIVE BREAST CANCER (TNBC)
Authors: Brianese Rafael Canfield , Santiago Karina Miranda , Torrezan Giovana Tardin , Brot Marina de , Rocha José Claudio Casali da , Makdissi Fabiana Baroni Alves , Carraro Dirce Maria
Published: April 2023

Objective: Triple-negative breast cancer (TNBC) is a breast cancer subtype strongly associated with BRCA1 germline mutations that are involved in homologous recombination DNA repair deficiency (HRD). Tumors with HRD may benefit from DNA-damage-inducing agents and PARP inhibitors. We aim to characterize germline mutations in HRD-related genes in TNBC and associate them with clinical data. Methods: TNBC patients (n=117) attending the A.C.Camargo Cancer Center had genetic testing performed by NGS (26–127 cancer predisposition gene panels) in leukocyte/saliva DNA. When possible, germline variants were screened in tumor DNA for loss-of-heterozygosity (LOH). Results: All patients were screened for germline variants: 26% (30/117) were Hereditary HRR-related, 21% BRCA1, 2% BRCA2, 2% PALB2, and 1% RAD51. For women diagnosed at a young age (<40 years), this rate increases to 38% (20/52), 31% BRCA1, 4% BRCA2, 2% PALB2, and 1% RAD51. In addition, 37% of cases presented variants of uncertain significance (VUS). LOH analysis showed that 100% (6/6) of pathogenic variants had LOH, while only 30% of VUS had LOH. Interestingly, for two cases with concurrent pathogenic and VUS, only the pathogenic variant exhibits LOH. Additionally, 47% (7/15) of the VUS with LOH were in HRR-related genes. Conclusion: The majority of germline variants in TNBC are in the BRCA1 gene, but other HRR-related genes also contribute to HRD. LOH analysis may help classify VUS regarding pathogenicity.
VALIDATION OF A NOVEL IN VITRO BREAST CANCER CHEMORESISTANCE PLATFORM IN NEOADJUVANT SETTING
Authors: Lichtenfels Martina , Silva Camila Alves da , Souza Alessandra Borba Anton de , Rezende Heloisa , Kobe Luiza , Miranda Isabela , Frasson Antônio Luiz , Farias Caroline Brunetto de
Published: April 2023

Objective: The aim of this study was to validate a novel in vitro chemoresistance platform for two drugs commonly used in the neoadjuvant setting for breast cancer (BC). Methods: Three BC cell lines (MCF-7 (luminal); SKBR3 (HER2+); and MDA-MB-231 (triple-negative) were used to confirm the efficacy of the platform. Patients with invasive BC and partial response to neoadjuvant chemotherapy were included in this initial report. Fresh tumor samples were collected during surgery and dissociated to obtain the tumor cells. The tumor cells were cultured in the chemoresistance platform with doxorubicin and paclitaxel and after 72-h cell viability was evaluated. The test result is defined based on cell viability as low (60%) resistance. Results: The three BC cell lines presented low resistance to doxorubicin, MCF-7 and SKBR3 cells also presented low resistance to paclitaxel, whereas MDA-MB-231 has intermediate resistance. Samples from 10 BC patients with partial response to neoadjuvant chemotherapy were tested in the novel chemoresistance platform. All the patients received doxorubicin and paclitaxel as part of the treatment. The overall rate of assay success was 100%. Regarding molecular subtypes, 40% were Luminal, 20% Luminal HER2, 10% HER2, and 30% triple-negative. The 10 samples presented 100% high resistance to paclitaxel. High resistance to doxorubicin was observed in 70% of the samples, intermediate in 10%, and low in 20%. The chemoresistance platform demonstrated that samples already treated with paclitaxel and doxorubicin in a neoadjuvant setting presented more high resistance to the drugs compared to the BC cell lines. Conclusion: This preliminary result demonstrated more high resistance in tumors previously treated with doxorubicin and paclitaxel compared to BC cell lines without previous treatment and highlighted the success of the in vitro chemoresistance platform to test tumor samples after neoadjuvant treatment.
INVESTIGATION OF CIRCULATING TUMOR DNA (CTDNA) IN PATIENTS WITH NON-METASTATIC TRIPLE-NEGATIVE BREAST CANCER (TNBC) SUBMITTED TO NEOADJUVANT CHEMOTHERAPY
Authors: Brianese Rafael Canfield , Torrezan Giovana Tardin , Andrade Marina de Brot , Lima Vladmir Claudio Cordeiro de , Sanches Solange Moraes , Formiga Maria Nirvana da Cruz , Makdissi Fabiana Baroni Alves , Carraro Dirce Maria
Published: April 2023

Objective: Loss-of-function germline mutation in BRCA1 increases breast cancer risk, especially in the triple-negative breast cancer (TNBC) subtype. BRCA1 impairment may confer benefit from the treatment with DNA damage-inducing drugs and PARP1 inhibitors. Patients who respond to neoadjuvant chemotherapy tend to have good outcomes. The aim of this study was to characterize the resistance to chemotherapy in patients with germline-characterized TNBC by investigating somatic mutations in ctDNA. Methods: Germline genetic testing was done using cancer-predisposing gene panels (26–126 genes) to classify TNBC as hereditary or sporadic. Somatic mutation identification in tumor (409 cancer-related gene panel) and screening of ctDNA in plasma samples during treatment were performed. Results: We enrolled 96 TNBC patients of which 88 were tested for germline variants: 23% (20/88) of cases were hereditary – BRCA1 (16%), BRCA2 (4%), PALB2 (1%), RAD51D (1%), and TP53 (1%). Tumor mutation burden (TMB) analysis (43 cases) showed that 11.6% had high and 89.4% had low TMB, not associated with hereditary status. We found, on average, 3 somatic variants per tumor (range 1–7) and used them as tumor marks for screening ctDNA in plasma. Somatic mutations in TP53 were identified in most tumors (71%). In ctDNA before treatment, detection of at least one tumor mutation was observed in 24 out of 30 patients (80%), and no association was observed between hereditary status and TMB score. Although ctDNA was not associated with the residual cancer burden score, ctDNA-positive patients were associated with clinical progression, either at baseline or during monitoring (post-neoadjuvant chemo), and ctDNA identification anticipated progression detected by imaging. Conclusion: Hereditary tumors, markedly due to germline variants in BRCA1, are frequent in TNBC. Tumor-mark identification using gene panels and ctDNA screening in plasma samples provide valuable information regarding the clinical progression of patients treated with preoperative chemotherapy.
APPLICATION OF A REMOTE, FULLY ORIENTED PERSONALIZED PROGRAM OF PHYSICAL EXERCISE FOR WOMEN IN FOLLOW-UP AFTER BREAST CANCER TREATMENT: EFFECTS ON BODY COMPOSITION AND PHYSICAL FITNESS
Authors: Rocha José Claudio Casali da , França-Lara Édipo Giovani , Weber Saulo Henrique , Pinho Ricardo de Aurino , Elifio-Esposito Selene
Published: April 2023

Objective: Getting back to regular physical activity soon after completing the treatment for breast cancer may be a challenge for most women. To assess the impact of physical exercise on physical fitness and body composition in women who have completed breast cancer treatment, we designed a personalized program of physical exercises, considering their individual basal physical activity levels. Methods: The prospective study included 107 women aged 18–60 years shortly after curative treatment for localized breast cancer. All participants were evaluated for cardiovascular morbidities, body composition, and exercise performance. After careful physical evaluation by a personal physical trainer, each woman was individually oriented on how to perform each exercise correctly and follow the program of nonsupervised exercises on their own at home, either indoor or outdoor. Women were motivated to adhere to personalized aerobic exercises, localized muscular strength/resistance, and flexibility exercises, considering individual capabilities and limitations. Evaluations including body composition, VO2max, and localized muscle resistance were performed preintervention (basal) and after 6 and 9 months of intervention. Results: Among all, 25.23% and 44.85% were fat or overweight, respectively, at the study entrance, and 21.49% reported doing physical exercise regularly; 78 women adhered to the training program (72.8%), and 29 chose not to adhere (27.2%). After 9 months of regular and individualized intervention, adherent women showed significantly better results in all variables of body composition and physical fitness: body mass (-4.38±3.67 kg; p0.05), as well as it was not influenced by breast cancer characteristics (e.g., histology, stage, and molecular subtypes) or treatment (e.g., mastectomy, axillary surgery, chemotherapy, or radiotherapy) (p>0.05). Conclusion: Our study reinforces that women in follow-up after breast cancer, regardless of body fatness or fitness, can adopt lifestyle measures to prevent a recurrence, and medical societies should include recommendations to promote physical activity early during surveillance.
COMPARISON OF FUNCTIONAL PERFORMANCE AND KINESIOPHOBIA BETWEEN BREAST CANCER SURVIVORS AND APPARENTLY HEALTHY WOMEN
Authors: Marques Vitor Alves , Santos Wanderson dos , Ferreira-Junior João , Silva Maria , Silva Naiany , Alves Rafael , Noleto Flavia , Vieira Carlos
Published: April 2023

Objective: The aim of this study was to compare functional performance and kinesiophobia between breast cancer survivors and apparently healthy women. Methods: In all, 62 women participated the study and they were divided into a control group (CNT) (age: 52.16±7.59) composed of healthy women and breast cancer survivors (SCM) (age: 52.93±8.95). The functional performance was evaluated by the DASH and the kinesiophobia; it was evaluated by the Tampa Scale. The normality of the data was evaluated by the Shapiro-Wilk test. Data were analyzed by the Student’s t-test. The significance level was defined a priori at p <0.05. The unpaired t-test was used to compare functional performance, and the MannWhitney U test was used to compare kinesiophobia. Results: The SCM group showed worse levels of functional performance (p<0.001) and higher levels kinesiophobia than the CNT group (p=0.05). Conclusion: SCM women have low levels of functional performance and higher levels of kinesiophobia
“A Different Perspective”: Topics Discussed During African American Father-Daughter Sexual Health Communication
Authors: Kachingwe Olivia
Published: April 2023

African American youth and young adults are disproportionately burdened by HIV and sexually transmitted infections. Although African American parent-child sexual health communication has been shown to reduce adolescent sexual risk-taking behavior, much more is known about mother-child and father-son sexual health communication than father-daughter sexual health communication. The current study explores what sexual health topics African American father-daughter dyads discuss with one another, and which topics are perceived to have the greatest impact on youths’ sexual risk behavior. Seven father-daughter dyads (N=7) and an additional five daughters (n=5) completed individual in-depth semi structured interviews. Daughters were aged 19-21 (M=20.3) years and fathers were aged 52-60 (M=56.7) years. Thematic analysis revealed five themes including: challenging topics to discuss, easy topics to discuss, topics on the continuum, desired topics of communication, and topics with greatest impact on behavior. Although participants shared that discussing sexual health is considered culturally taboo and can be challenging when criticized, several topics were easy to discuss universally, and several topics were both challenging and easy to discuss depending on the context of the conversation and depth of content covered. Sexual health communication was largely perceived as positively impacting daughters’ behaviors and daughters expressed wanting to have these conversations. Study findings can inform future intervention development by indicating which sexual health topics should be prioritized during father-daughter communication given their perceived positive impact. Future research is needed to explore how best to support father-daughter dyads in discussing sexual health topics perceived as challenging.  
ATUAÇÃO DO FARMACÊUTICO CLÍNICO NO MANEJO DE PACIENTES ADULTOS COM CARDIOPATIA CONGÊNITA EM UNIDADE DETERAPIA INTENSIVA
Authors:   Hospital São Camilo, Rodrigues Marcatto Leiliane , Silva Fernandes D’Angelo Bruna ,   Irmandade Santa Casa de Misericórdia de São Paulo
Published: April 2023

O número de adultos com cardiopatia congênita (CC) vem aumentando cada vez mais e isso se deve aos avanços das técnicas cirúrgicas e tratamento médico de crianças com CC. A sobrevida e a complexidade do manejo desses pacientes são uma realidade, e às vezes é necessário o gerenciamento desses pacientes em uma unidade de terapia intensiva (UTI). Há diversas complicações que esses pacientes podem apresentar quando internados em uma UTI como, por exemplo, disfunções hepáticas e renais, arritmia, choque cardiogênico, doenças infecciosas, entre outras. A atuação do farmacêutico clínico dentro da equipe multidisciplinar na UTI pode ajudar no manejo desses pacientes. Dessa forma, esta revisão traz de forma resumida as principais complicações que o paciente com CC pode apresentar dentro da unidade de terapia intensiva e como o farmacêutico clínico pode atuar em cada complicação, diminuindo assim os problemas relacionados aos medicamentos, garantindo maior efetividade terapêutica e diminuindo a morbimortalidade entre esses pacientes
THE EXCHANGE RATE AS AN INSTRUMENT OF MACROECONOMIC STABILIZATION AND DEVELOPMENT OF THE NATIONAL ECONOMY OF UKRAINE
Authors:   State Tax University, Bereslavska Olena
Published: April 2023

The exchange rate is an instrument of state influence on macroeconomic and macro-financial processes. A correctly chosen exchange rate regime and its effectiveness create conditions for the development of the national economy, maintaining low inflation rates, achieving balance of payments balance, ensuring macroeconomic stability, raising the standard of living of the population, and strengthening the confidence of investors in the national monetary unit. International practice proves that the introduction of an adequate exchange rate regime helps to overcome crisis phenomena in the country’s economy. When developing a market economy, Ukraine implemented various exchange rate regimes – from rigidly fixed, regulated to free floating. At the beginning of the war in Ukraine, the monetary authorities returned to the fixed exchange rate regime, which allowed to stabilize inflation and contribute to reducing the decline of the economy. In this context, the chapter examines theoretical approaches to the choice of the exchange rate regime, conducts a retrospective analysis of the impact of the exchange rate regime on the main macroeconomic indicators of the national economy. An assessment the impact of the regime free floating of the hryvnia on the development the economy is carried out. The advantages of returning to a fixed exchange rate regime during wartime are considered. The result of the conducted assessments and analysis is the conclusion that the influence of the exchange rate regime in Ukraine was multi-vector. The regime of regulated hryvnia exchange rate was the most effective for the country, but its inadequacy in certain time periods and external shocks led to wave devaluations, which provoked crisis phenomena and had a negative impact on the main economic indicators.
BANKING REGULATION IN CONDITIONS OF FINANCIAL INSTABILITY: NEW CHALLENGES, ANTI-CRISIS MEASURES, PROMISING VECTORS
Authors:   Azerbaijan State University of Economics (UNEC), Muslum Mursalov
Published: April 2023

The article deals with modern problems of the influence of banking regulation on financial stability in the context of global turbulence. New challenges affecting this process are revealed. The role of banking regulatory tools in the likelihood of a banking crisis has been established. The relevance of the influence of banking regulation on green investments is determined. A bibliometric analysis was implemented using VOSviewer based on Scopus publications on relevant topics, which made it possible to identify contextual, geographical and temporal models for studying the relationship between banking regulation and green investment. The main directions of the impact of digitalization on the transformation of the banking regulation process are presented, a comprehensive study of which will allow developing fundamentally new approaches to its improvement. The expediency of implementing innovative practical measures to improve the efficiency of the banking regulation system has been substantiated. In the conclusion, the main findings are formulated, which, from the author’s point of view, will contribute to the improvement of the banking regulation system in the context of digitalization.
THE “MOSQUITO SHAMAN’S” SONG-SPELL (BLOOD-SUCKING INSECTS IN THE CULTURE OF THE NENETS AND OB UGRIANS)
Authors:   Peter the Great Museum of Anthropology and Ethnography (Kunstkamera) of the RAS, Perevalova Elena V.
Published: April 2023

The article examines the attitude of the Nenets and Ob Ugrians to blood-sucking insects. Winged (mosquito, midge, woodlouse, gadfly) and wingless (louse) blood-sucking insects are considered by the Nenets and Ob Ugrians as belonging to the Lower World. In folklore, their appearance is associated with the witch Parne and other representatives of the dark worlds (dungeons, forest thickets, water depths), whose ashes turn into midges and are carried by the wind. The mosquito years are a living hell for the inhabitants of the tundra and taiga. The description of meetings with bloodsuckers is close to the rhetoric of war. At the same time, they turn out to be similar to a person in their behavior and appearance (they wear fur and iron clothes), but folklore also emphasizes their otherness, contains indications of ethnic opposites (for example, comparison with hostile neighbors). In the view of the forest Nenets, the song-spell performed annually with the rite of sacrifice to the “mosquito shaman” makes it possible to somehow influence on the number of insects flying out during the flowering of the vermilion. It is believed that the Nenets shamans, whose costumes were decorated with metal castings of insects (gadflies and their larvae), were able to regulate blood-sucking insects, annoying people and deer. Archaeological finds in the north of Western Siberia of metal figurines of blood-sucking insects indicate the antiquity of a special attitude towards them. We can talk about a wider inclusion of blood-sucking insects in the structure of the universe of the Samoyeds than among the Ob Ugrians (the names of the summer months, the existence of the genus Nenyang (Mosquito), a folklore plot with the punishment of a person for disrespectful attitude, the use of images as spirits-assistants of shamans and in the funeral rite). At the same time, the wide distribution of various folklore plots with the participation of insects among the Ob Ugrians and the findings of figurines of gadflies (ranked as blood-sucking) at the archaeological sites of the Lower Ob region suggests that this is a rather ancient layer of the culture of the population of Western Siberia.
THE NEOLITHIC–ENEOLITHIC TRANSITION IN THE FOREST-STEPPE AND FOREST MIDDLE VOLGA REGION: FORMS, MODELS AND CHRONOLOGICAL FRAMEWORK
Authors:   Samara State University of Social Sciences and Education, Andreev Konstantin M. , Kudashov Aleksandr S. ,   Samara State University of Social Sciences and Education, Somov Anatoliy V. ,   Samara State University of Social Sciences and Education, Shalapinin Anton A. ,   Samara State University of Social Sciences and Education
Published: April 2023

The transition from the Neolithic to the Eneolithic in the forest-steppe and forest zones of the Middle Volga region is a very complex and multi-vector process. The Samara and Khvalynsk cultures of the forest-steppe Volga region are newcomers and have fundamental differences from the materials of the Srednevolzhskaya Neolithic culture at the early stages of development. The results of radiocarbon dating indicate the time of their coexistence from the beginning to the third quarter of the 5th millennium BC. During the specified period, the indicated groups interact with varying degrees of intensity from the borrowing of individual features to the appearance of syncretic types of dishes (type Lebyazhinka III, the Ivanovo stage of the Samara culture). As a result, these processes lead to the formation of a number of Late Eneolithic cultural types (Chekalinsky and Toksky). In the forest zone of the Middle Volga region, there is a gradual transition from the Neolithic to the Eneolithic. The Neolithic groups of this region (carriers of the Kama comb and Volga-Oka combpit traditions) actively interact with each other, which was reflected in the formation of Krasnyy Most type of ceramics in the last quarter of the 5th millennium BC. In turn, in the first half of the 4th millennium BC, the Krasnyy Most type of ceramics became one of the main components of the Middle Volga variant of the Volosovo Eneolithic culture.
LITERARY EXCURSIONS AS A METHOD OF PERPETUATING THE CULTURAL HISTORY OF THE CITY: ON THE PROBLEM OF STUDYING
Authors:   Bashkir State Pedagogical University, Sultangareeva Rozaliya A. , Khubbitdinova Nerkes A. ,   Bashkir State Pedagogical University, Shagapova Gulkay R. ,   Bashkir State Pedagogical University, Shakurova Shaura R. ,   Bashkir State Pedagogical University
Published: April 2023

The article considers the problems associated with the perpetuation of monuments of the history of culture of the city of Ufa, one of the ways of which is organizing and conducting literary excursions. The capital of the Republic of Bashkortostan has a rich past and is closely connected with the brightest and stormy pages of the history of the country as a whole. The article, using the example of the description of the route along Gogol Street, attempts to identify the key points that need to be taken into account when working on the routes of a literary tour of the city of Ufa. In this case, we are talking about pre-revolutionary Ufa, Bashkir and Russian culture. The study of the urban landscape shows the prospects of thematic walking routes. The systematization of the material demonstrates the insignificant involvement of the authorities in the process of perpetuating the cultural heritage of the city, the scattering of memorable places associated with the names of famous writers, which causes difficulties in their visual demonstration. The authors of the article come to the conclusion that the chosen direction is promising and actively developing, it contributes to the preservation of the cultural heritage of the city of Ufa.
BURIAL CONSTRUCTION OF THE LATE NEOLITHIC CEMETERY AVTODROM-1 IN NORTH-WESTERN BARABA: ARCHAEOLOGICAL SPECIFICS AND ISSUES OF INTERPRETATION
Authors:   Institute for Human Ecology of the Federal Research center of the Siberian Branch of the Research Center of Coal and Coal-Chemistry of the RAS, Bobrov Vladimir V. ,   Kemerovo State University, Marochkin Аlexey G. ,   Institute for Human Ecology of the Federal Research center of the Siberian Branch of the Research Center of Coal and Coal-Chemistry of the RAS
Published: April 2023

The Late Neolithic of the Middle Irtysh-Barabinsk region is presented by the Artyn culture (mid of the IVth — first half of the Vth millenary BC). The “Artyn” population’s burial practice is reflected in the materials from Protoka, Vengerovo-2A, Ust-Tatrtas-2, Avtodrom-1 cemeteries. The specifics of the Avtodrom-1 burial construction correlate with the other cemeteries of the series, they all have a common burial pit, storied arrangement of remains in the pit, covering with small soil mound, surrounded with an unclosed ditch. Morphologically, the burial constructions are similar to the dwellings with ditches known from the Late Neolithic materials in the Middle Irtysh River (the Artyn culture) and Surgut Ob River region (the Bystrino culture). The specifics of the Avtodrom-1 burial constructions and other cemeteries of this typological group allow suggesting the following order of rituals: creation of the main bowl-shaped pit and pitches around it; erection of a burial construction on the ground with a thick sod-soil covering; burials with partial covering of the pit with soil at each level, following crash of the ground construction which made a small hill. Historically, this is one of the most ancient manifestations of kurgan burial tradition with semantical symmetry — dwelling-burial, with sacral burial surface emphasized in relief. This marks the Artyn culture cemeteries apart the necropolis of other Neolithic cultures of Southern Siberia with their in-soil mostly individual inhumations. Theoretically, this tradition is connected with clan groups who buried in individual tombs.