bluuebunny/crossref_metadata_2025 huggingface dataset:
Stochastic Medium Model for the Settlement Calculation of Prefabricated Vertical Drains of Soft Soil Foundations in the Coastal Area of South China
Authors: Liu Zhen , Gao Yi , Liao Jin , Zhou Cuiying
Published: June 2022

The prefabricated vertical drain (PVD) is an essential means to mitigate the settlement of soft soil foundations in coastal areas of South China. The commonly used elastoplastic analytical method cannot directly reflect the interaction of different PVDs and the resulting displacement of soft soil. At the same time, these elastoplastic analysis and numerical simulation methods are greatly influenced by the values adopted for rock and soil material parameters. In this paper, we present a stochastic medium model that can directly reflect the interaction of different PVDs and the resulting displacement of soft soil. It is not affected by the characteristics of rock and soil themselves and can also reflect the actual deformation process of soft soil. According to engineering practice, the settlement curves of soft soil foundations in coastal areas of South China with PVDs exhibited distinct normal distribution characteristics, which was consistent with the description of settlement by the stochastic medium model. Hence, based on the stochastic medium model, this paper analyzed the settlement mechanism of PVDs and established a stochastic medium model for the settlement calculation of PVDs. A function for the soft soil foundation in the coastal area of South China cross-section settlement curve was presented by back analysis of the PVD model. We chose the stochastic medium model based on this methodology to explore the interaction between different PVDs. The above models were then applied to an expressway in South China. Comparing actual settlement monitoring values to calculated values obtained with the PVD model, the error between the two models was less than 15%. This research provides a new settlement calculation method of PVDs in soft soil foundations in the coastal area of South China and a new basis for designing soft soil foundations.
Effect of Cross-Joints Fin on the Thrust Performance of Bionic Pectoral Fins
Authors: Lu Yang , Cao Yonghui , Pan Guang , Huang Qiaogao , Dong Xin , Cao Yong
Published: June 2022

Cownose rays have a high forward propulsive performance due to their unique oscillating fin structure (named the cross-bracing structure), which differs from undulatory fish. The cross-bracing structure obtained through anatomy, on the other hand, is extremely complex. Hence, researchers used simple structures to model the biological structure to target the individual factors that affect cownose ray cruising performance. This paper simplified the cross-bracing fin structure to a cross-joints fin (CJF) structure with 18 designs. CJFs had five different joint widths (2 mm, 3 mm, 4 mm, 5 mm, and 6 mm) in both spanwise and chordwise directions, and these had two fin thicknesses (1.5 mm, 2.5 mm). The joint widths of CJF are related to the stiffness of the spanwise and chordwise fins (Fin stiffness increases with joint width). The experiments were conducted in a still water tank (1.5 m × 0.8 m × 0.8 m) with three stroke amplitudes (30°, 50°, 70°) and three flapping frequencies (0.4 Hz, 0.6 Hz, 0.8 Hz) for each fin, making up 162 distinct sets of data. The experimental results showed the following: (1) at low wingtip Reynolds numbers, the high stiffness of the CJF causes a significant reduction in thrust. In particular, high stiffness results in a low thrust averaged from all motion parameters; (2) at high wing tip Reynolds numbers, the effect of changing spanwise stiffness on thrust is more significant than the effect of changing chordwise stiffness. This paper compares the effects of spanwise and chordwise stiffness on thrust performance, indicating that the magnitude of spanwise stiffness should be considered when designing the bionic oscillating pectoral fin structure.
Evaluating Shipping Efficiency in Chinese Port Cities: Four-Stage Bootstrap DEA Model
Authors: Wu Letian , Wang Chuanxu
Published: June 2022

This study examines shipping efficiency and its influencing factors in 19 Chinese port cities using a four-stage bootstrap DEA approach. Infrastructure, asset investment, and labor are selected as its inputs; cargo throughput and cargo turnover are selected as the outputs. First, in the three-stage DEA model, the SFA regression method is used to eliminate the impact of external environmental factors and random factors on shipping efficiency. Furthermore, the Bootstrap DEA method is applied to correct deviation to solve the problem of the traditional DEA method being sensitive to the number of variables of a chosen sample. Finally, the real shipping efficiency of the port cities is measured. The empirical results show that the shipping efficiency of each port city is affected by the factors of foreign trade, population size, economic development, consumption level, and government support. Additionally, the average efficiency values of port cities in the eastern region is higher than the general average at each stage; on the contrary, the average efficiency values in the central and western regions are lower than the general average. Finally, the study provides policy implications for the future improvement of shipping efficiency.
Correlation between Pressure Minima and Cavitation Inception Numbers: Fundamentals and Hydrofoil Flows
Authors: Amromin Eduard , Rozhdestvensky Kirill
Published: June 2022

Cavitation inception predetermines a jump of noise radiated from marine vehicles. Usually marine propellers are the main sources of such a noise. In the situation of cavitation inception near the blade’s leading edge, its prediction remains a challenge. Though contemporary CFD tools for fully turbulent flows satisfactorily predict pressure distribution around cavitation-free blades and with cavities of length comparable with the blade size, analysis of blade cavitation inception is a difficult task for these tools. On the other hand, there are validated computational tools for 2D multizone flows capable of predicting cavitation inception. There is the possibility of considering the real 3D flow around the leading edges of blades as a 2D flow with the known pressure distribution along the blade section; the cavitation inception number is computed in this 2D cavitating flow, and correlations between this number and the pressure minimum in cavitation-free flow around the same section are determined. Such a correlation would be usable with any tool for cavitation-free flow. The issue of their applicability to arbitrary blades can be solved with the employment of asymptotic solutions for the pressure around contours with rounded leading edges.
On Sound Scattering and Acoustic Properties of the Upper Layer of the Sea with Bubble Clouds
Authors: Bulanov Vladimir A. , Bugaeva Lubov K. , Storozhenko Andrey V.
Published: June 2022

The presence of bubbles near the sea surface under certain conditions leads to abnormal sound scattering and a significant change in the acoustic properties of the upper layer of the sea. The article presents some results of sound scattering studies under various sea conditions, up to stormy conditions, when extensive bubble clouds arise. By the method of unsteady acoustic spectroscopy, data on the size distribution of bubbles at various depths have been obtained, which can be described by a power function with exponential decay at small bubble sizes of the order of 10 microns. Estimates of the gas content in bubble clouds and their influence on the acoustic characteristics of the upper layer of the sea have been carried out. It is shown that at sufficiently high concentrations, sharp increases in absorption and dispersion of the sound velocity are observed. Modeling of sound propagation in the presence of a quasi-homogeneous bubble layer shows that it leads both to a change in the laws of the average decay of the sound field along the sound propagation path and to a change in the shallow spatial structure of the field.
Optimization of Container Shipping Network Reconfiguration under RCEP
Authors: Li Junjun , Zhao Hang , Xu Bowei
Published: June 2022

Due to its advantages of large transportation volume and low transportation cost, container shipping has become an important transportation mode in current international trade. The recovery of the shipping industry in 2021 and the signing of RCEP make the reconfiguration and optimization of the container shipping network a very important task at present. The network service capability is an important factor affecting the container shipping network. Based on the complex network theory, the coefficients of port location, the importance of distance and route among ports are taken as the service capacity reconfiguration coefficients of the global container shipping network. A max-min mixed integer model is established for global container shipping network reconfiguration. A sort of communication-reducing conjugate gradient method based on Krylov Subspace (CR-CG-KS) is proposed to reduce the reconfiguration computation. The results show that the global container shipping network does not need large-scale reconfiguration but requires small-scale changes to optimize the network feature vector centrality and make the network more balanced and stable. This study is beneficial for business managers to proactively respond to the future development of the shipping network and improve the operational efficiency of the global container shipping network.
A Novel Conformal Coil Structure Design of Wireless Power Transfer System for Autonomous Underwater Vehicles
Authors: Liu Peizhou , Gao Tiande , Zhao Ruixuan , Mao Zhaoyong
Published: June 2022

A coil structure that is compatible with the structure of the autonomous underwater vehicles (AUVs) and preventing the rotational misalignment is proposed for stabilizing the output power of a wireless power transfer (WPT) system. The transmitting coil and the receiving coil are wound on the structure of the energy base station and the AUV in a spiral tube type, respectively. This arrangement not only guarantees a constant mutual inductance when the AUV rotates, but it also maintains the efficient transmission of energy when the receiving coil is conformal with the AUV by optimizing the size of the magnetic core and the distance between the coil and the metal structure. The performance of the proposed coil structure is experimentally evaluated by building an inductor–capacitor–capacitor series (LCC-S)-compensated WPT prototype. It was found that the system can stably deliver a 2 kW power with a dc–dc efficiency of 92.7%.
Dexterity Based Viscous Resistance Optimization of a Deep-Sea Manipulator
Authors: Bai Yunfei , Zhang Qifeng , Zhang Aiqun
Published: June 2022

With persistent ocean exploration, the complexity of deep-sea intervention is gradually increasing. The deep-sea manipulator is the primary tool to complete complex intervention. The manipulator dexterity determines the complexity of the task it can perform. First, a dynamic dexterity evaluation method is proposed based on the kinematics and dynamics characteristics of the deep-sea manipulator. This method takes into account the dynamic torque boundary and Jacobian mapping constraint, which are different from terrestrial manipulators. The concepts of the dynamic dexterity ellipsoid and dynamic dexterity measure are defined. Second, the effect of viscosity resistance on dexterity is analyzed. The viscosity resistance is optimized by selecting the most suitable compensation oil. Finally, the methods of dynamic dexterity evaluation and viscosity resistance optimization are verified by a simulated deep-sea experiment. The method proposed in this paper effectively improves the dynamic dexterity of the deep-sea manipulator by optimizing the viscosity resistance. The proposed method can also be used to evaluate and improve the dexterity of other underwater manipulators.
Assessment of Three-Dimensional Interpolation Method in Hydrologic Analysis in the East China Sea
Authors: Gao Yuchun , Guo Junting , Wang Jianfeng , Lv Xianqing
Published: June 2022

The water mass in the East China Sea (ECS) shelf has a complicated three-dimensional (3D) hydrologic structure. However, previous studies mostly concentrated on the sea surface based on the sparse in situ and incomplete satellite-derived observations. Therefore, the 3D interpolation technology was introduced for the reconstruction of hydrologic structure in the ECS shelf using in situ temperature and salinity observations in the summer and autumn of 2010 to 2011. Considering the high accuracy and good fitness of the radial basis function (RBF) methods, we applied the RBF methods to the in situ observations to completely reconstruct the 3D hydrologic fields. Other 3D interpolation methods and 2D methods were also tested for a comparison. The cubic and thin plate spline RBFs were recommended because their mean absolute error (MAE) in the 10-fold cross-validation experiments maintained the order of ~10−2. The 3D RBF reconstructions showed a reasonable 3D hydrologic structure and extra details of the water masses in the ECS shelf. It also helps evaluate regional satellite-derived sea surface temperature (SST). Comparisons between the interpolated and satellite-derived SST indicates that the large bias of satellite-derived SST in the daytime corresponds to weak mixing during low-speed wind and shows seasonal variation.
Multigene Phylogeny, Beauvericin Production and Bioactive Potential of Fusarium Strains Isolated in India
Authors: Rana Shiwali , Singh Sanjay Kumar , Dufossé Laurent
Published: June 2022

The taxonomy of the genus Fusarium has been in a flux because of ambiguous circumscription of species-level identification based on morphotaxonomic criteria. In this study, multigene phylogeny was conducted to resolve the evolutionary relationships of 88 Indian Fusarium isolates based on the internal transcribed spacer region, 28S large subunit, translation elongation factor 1-alpha, RNA polymerase second largest subunit, beta-tubulin and calmodulin gene regions. Fusarium species are well known to produce metabolites such as beauvericin (BEA) and enniatins. These identified isolates were subjected to fermentation in Fusarium-defined media for BEA production and tested using TLC, HPLC and HRMS. Among 88 isolates studied, 50 were capable of producing BEA, which varied from 0.01 to 15.82 mg/g of biomass. Fusarium tardicrescens NFCCI 5201 showed maximum BEA production (15.82 mg/g of biomass). The extract of F. tardicrescens NFCCI 5201 showed promising antibacterial activity against Staphylococcus aureus MLS16 MTCC 2940 and Micrococcus luteus MTCC 2470 with MIC of 62.5 and 15.63 µg/mL, respectively. Similarly, the F. tardicrescens NFCCI 5201 extract in potato dextrose agar (40 µg/mL) exhibited antifungal activity in the food poison technique against plant pathogenic and other fungi, Rhizoctonia solani NFCCI 4327, Sclerotium rolfsii NFCCI 4263, Geotrichum candidum NFCCI 3744 and Pythium sp. NFCCI 3482, showing % inhibition of 84.31, 49.76, 38.22 and 35.13, respectively. The antibiotic effect was found to synergize when Fusarium extract and amphotericin B (20 µg/mL each in potato dextrose agar) were used in combination against Rhizopus sp. NFCCI 2108, Sclerotium rolfsii NFCCI 4263, Bipolaris sorokiniana NFCCI 4690 and Absidia sp. NFCCI 2716, showing % inhibition of 50.35, 79.37, 48.07 and 76.72, respectively. The extract also showed satisfactory dose-dependent DPPH radical scavenging activity with an IC50 value of 0.675 mg/mL. This study reveals the correct identity of the Indian Fusarium isolates based on multigene phylogeny and also throws light on BEA production potential, suggesting their possible applicability in the medicine, agriculture and industry.
Usefulness of ß-d-Glucan Assay for the First-Line Diagnosis of Pneumocystis Pneumonia and for Discriminating between Pneumocystis Colonization and Pneumocystis Pneumonia
Authors: Bigot Jeanne , Vellaissamy Sandra , Senghor Yaye , Hennequin Christophe , Guitard Juliette
Published: June 2022

According to the immunodepression status, the diagnosis of Pneumocystis jirovecii pneumonia (PjP) may be difficult. Molecular methods appear very sensitive, but they lack specificity because Pj DNA can be detected in Pneumocystis-colonized patients. The aim of this study was to evaluate the value of a serum ß-d-Glucan (BDG) assay for the diagnosis of PjP in a large cohort of HIV-negative and HIV-positive patients, either as a first-line diagnostic test for PjP or as a tool to distinguish between colonization and PjP in cases of low fungal load. Data of Pj qPCR performed on bronchopulmonary specimens over a 3-year period were retrieved retrospectively. For each result, we searched for a BDG serum assay performed within ±5 days. Among the 69 episodes that occurred in HIV-positive patients and the 609 episodes that occurred in immunocompromised HIV-negative patients, we find an equivalent sensitivity of BDG assays compared with molecular methods to diagnose probable/proven PjP, in a first-line strategy. Furthermore, BDG assay can be used confidently to distinguish between infected and colonized patients using a 80 pg/mL cut-off. Finally, it is necessary to search for causes of false positivity to increase BDG assay performance. BDG assay represents a valuable adjunctive tool to distinguish between colonization and infection.
Agaricus macrochlamys, a New Species from the (Sub)tropical Cloud Forests of North America and the Caribbean, and Agaricus fiardii, a New Synonym of Agaricus subrufescens
Authors: Medel-Ortiz Rosario , Garibay-Orijel Roberto , Argüelles-Moyao Andrés , Mata Gerardo , Kerrigan Richard W. , Bessette Alan E. , Geml József , Angelini Claudio , Parra Luis A. , Chen Jie
Published: June 2022

Agaricus is a genus of fungi in the family Agaricaceae, with several highly priced edible and medicinal species. Here we describe Agaricus macrochlamys, a new species, in A. sect. Arvenses, sympatric and morphologically cryptic with the edible and medicinally cultivated mushroom, A. subrufescens. Phylogenetic analyses showed that A. macrochlamys is closely related to A. subrufescens, and that A. fiardii is a new synonym of A. subrufescens. Despite being morphologically cryptic, A. macrochlamys can be distinguished from A. subrufescens by several ITS and tef1α species-specific markers and a 4-bp insertion in the tef1α sequence. Furthermore, A. subrufescens is a cosmopolitan species, while A. macrochlamys distribution is so far restricted to Mexico, the Dominican Republic, and the United States.
Development and Validation of an UHPLC-MS/MS Method for the Simultaneous Determination of 11 EU-Regulated Mycotoxins in Selected Cereals
Authors: Kovač Marija , Nevistić Ante , Kovač Tihomir , Babić Jurislav , Šarić Antonija , Miličević Borislav , Panjičko Mario , Šarkanj Bojan
Published: June 2022

The availability of reliable sensitive multi-analyte methods for unambiguous determination of mycotoxins is crucial for ensuring food and feed safety, considering their adverse health effects and (co-)occurrence in various foods. Accordingly, a multi-mycotoxin confirmatory method for simultaneous determination of 11 mycotoxins regulated in cereals within the European Union (EU) using ultra-high performance liquid chromatography coupled to tandem mass spectrometry (UHPLC-MS/MS) was developed and in-house validated to fit the EU legislation requirements for analytical methods. A simple sample preparation was based on a solid–liquid extraction using a solvent mixture acetonitrile/water/formic acid (79/20/1, v/v/v) and a dilution of raw extract using water/acetonitrile/formic acid (79/20/1, v/v/v) before instrumental analysis. Average recoveries in all three validated cereal crop types (maize, wheat, and barley), spiked at multiple levels, were found acceptable for all analytes when matrix-matched calibration was used, ranging from 63.2% to 111.2% and also showing very good repeatability, with relative standard deviations below 20%. Matrix effect (SSE) evaluation revealed maize as the most complex of the three analyzed cereal matrices, with strong SSE (<50% and >150%) recorded for all 11 analyzed mycotoxins. An additional method verification was performed through successful participation in proficiency testing schemes, with the achieved z-scores generally in the acceptable range of −2 ≤ z ≤ 2. The obtained validation results demonstrated the suitability of the developed confirmatory multi-mycotoxin UHPLC-MS/MS method based on a dilute-and-shoot principle for the simultaneous determination of low concentrations of 11 EU-regulated mycotoxins in cereals, including aflatoxins B1, B2, G1 and G2, deoxynivalenol, fumonisins B1 and B2, zearalenone, T-2 and HT-2 toxins, and ochratoxin A.
Characterization and Functional Analysis of a New Calcium/Calmodulin-Dependent Protein Kinase (CaMK1) in the Citrus Pathogenic Fungus Penicillium italicum
Authors: Li Guoqi , Liu Shaoting , Wu Lijuan , Wang Xiao , Cuan Rongrong , Zheng Yongliang , Liu Deli , Yuan Yongze
Published: June 2022

Calcium (Ca2+)/calmodulin-dependent protein kinases (CaMKs) act as a class of crucial elements in Ca2+-signal transduction pathways that regulate fungal growth, sporulation, virulence, and environmental stress tolerance. However, little is known about the function of such protein kinase in phytopathogenic Penicillium species. In the present study, a new CaMK gene from the citrus pathogenic fungus P. italicum, designated PiCaMK1, was cloned and functionally characterized by gene knockout and transcriptome analysis. The open reading frame of PiCaMK1 is 1209 bp in full length, which encodes 402 amino acid residues (putative molecular weight ~45.2 KD) with the highest homologous (~96.3%) to the P. expansum CaMK. The knockout mutant ΔPiCaMK1 showed a significant reduction in vegetative growth, conidiation, and virulence (i.e., to induce blue mold decay on citrus fruit). ΔPiCaMK1 was less sensitive to NaCl- or KCl-induced salinity stress and less resistant to mannitol-induced osmotic stress, indicating the functional involvement of PiCaMK1 in such environmental stress tolerance. In contrast, the PiCaMK1-complemented strain ΔPiCaMK1COM can restore all the defective phenotypes. Transcriptome analysis revealed that knockout of PiCaMK1 down-regulated expression of the genes involved in DNA replication and repair, cell cycle, meiosis, pyrimidine and purine metabolisms, and MAPK signaling pathway. Our results suggested the critical role of PiCaMK1 in regulating multiple physical and cellular processes of citrus postharvest pathogen P. italicum, including growth, conidiation, virulence, and environmental stress tolerance.
High-Throughput Microbial Community Analyses to Establish a Natural Fungal and Bacterial Consortium from Sewage Sludge Enriched with Three Pharmaceutical Compounds
Authors: Ledezma-Villanueva Alejandro , Robledo-Mahón Tatiana , Gómez-Silván Cinta , Angeles-De Paz Gabriela , Pozo Clementina , Manzanera Maximino , Calvo Concepción , Aranda Elisabet
Published: June 2022

Emerging and unregulated contaminants end up in soils via stabilized/composted sewage sludges, paired with possible risks associated with the development of microbial resistance to antimicrobial agents or an imbalance in the microbial communities. An enrichment experiment was performed, fortifying the sewage sludge with carbamazepine, ketoprofen and diclofenac as model compounds, with the aim to obtain strains with the capability to transform these pollutants. Culturable microorganisms were obtained at the end of the experiment. Among fungi, Cladosporium cladosporioides, Alternaria alternata and Penicillium raistrickii showed remarkable degradation rates. Population shifts in bacterial and fungal communities were also studied during the selective pressure using Illumina MiSeq. These analyses showed a predominance of Ascomycota (Dothideomycetes and Aspergillaceae) and Actinobacteria and Proteobacteria, suggesting the possibility of selecting native microorganisms to carry out bioremediation processes using tailored techniques.
Telomere-to-Telomere Genome Sequences across a Single Genus Reveal Highly Variable Chromosome Rearrangement Rates but Absolute Stasis of Chromosome Number
Authors: Quenu Mathieu , Treindl Artemis D. , Lee Kate , Takemoto Daigo , Thünen Torsten , Ashrafi Samad , Winter David , Ganley Austen R. D. , Leuchtmann Adrian , Young Carolyn A. , Cox Murray P.
Published: June 2022

Genome rearrangements in filamentous fungi are prevalent but little is known about the modalities of their evolution, in part because few complete genomes are available within a single genus. To address this, we have generated and compared 15 complete telomere-to-telomere genomes across the phylogeny of a single genus of filamentous fungi, Epichloë. We find that the striking distinction between gene-rich and repeat-rich regions previously reported for isolated species is ubiquitous across the Epichloë genus. We built a species phylogeny from single-copy gene orthologs to provide a comparative framing to study chromosome composition and structural change through evolutionary time. All Epichloë genomes have exactly seven nuclear chromosomes, but despite this conserved ploidy, analyses reveal low synteny and substantial rearrangement of gene content across the genus. These rearrangements are highly lineage-dependent, with most occurring over short evolutionary distances, with long periods of structural stasis. Quantification of chromosomal rearrangements shows they are uncorrelated with numbers of substitutions and evolutionary distances, suggesting that different modes of evolution are acting to create nucleotide and chromosome-scale changes.
Editors’ Introduction to the Special Issue “Communication in Defense of Nonhuman Animals during an Extinction and Climate Crisis”
Authors: Freeman Carrie P. , Almiron Núria
Published: June 2022

When honored with the opportunity to edit our first Special Issue in a media journal, we knew that we would concentrate on the subdiscipline of “critical animal and media studies” (CAMS) [...]
Early Diagnosis of Kidney Damage Associated with Tobacco Use: Preventive Application
Authors: Tascón Javier , Prieto Marta , Casanova Alfredo , Sanz Francisco , Hernández Mezquita Miguel , Barrueco Ferrero Miguel , Gomez-Marcos Manuel , Garcia-Ortiz Luis , Vicente-Vicente Laura , Morales Ana ,   on behalf of BIOTAB Team
Published: June 2022

Although long-term smoking has been associated with chronic kidney disease, its effect on kidney function in early stages has not been clarified. Therefore, the proposed objectives were: (1) to identify subclinical kidney damage in smokers, through a panel of biomarkers; (2) to evaluate the progression of subclinical kidney damage after two years of consumption in these patients; and (3) study whether quitting smoking reduces kidney damage. A prospective study was carried out (patients recruited from a primary care centre and a clinical smoking unit). Kidney function was assessed using a panel of biomarkers and compared between smokers and non-smokers, taking into account potential risk factors for kidney damage. These results show, for the first time in the literature, the relationship between smoking and early (subclinical) kidney damage and provide a panel of biomarkers capable of detecting this condition (Neutrophil gelatinase-associated lipocalin, Kidney injury molecule-1, N-acetyl-beta-D-glucosaminidase, transferrin, and ganglioside-activating protein GM2). This study also indicates that subclinical damage is maintained when use continues, but can be reversed if patients stop smoking. The use of these biomarkers as diagnostic tools can be a preventive measure in the development of chronic kidney disease associated with smoking and in the prevention of acute events associated with potentially nephrotoxic pharmacological treatment in smokers. Trial registration number: NCT03850756.
Imaging Assessment of Interval Metastasis from Melanoma
Authors: Simonetti Igino , Trovato Piero , Granata Vincenza , Picone Carmine , Fusco Roberta , Setola Sergio Venanzio , Mattace Raso Mauro , Caracò Corrado , Ascierto Paolo A. , Sandomenico Fabio , Petrillo Antonella
Published: June 2022

Interval metastasis is a particular metastatic category of metastatic localizations in the lymph nodes in patients with melanoma. Interval nodes are generally located at nonregional lymphatic stations placed along the pathway of the spread of melanoma, such as the epitrochlear lymph node station, the popliteal fossa, and the retroareolar station. Imaging techniques for evaluation of patients with interval metastasis from melanoma diseases include ultrasound (US), computed tomography (CT), magnetic resonance imaging (MRI), lymphoscintigraphy (LS), and positron emission tomography (PET). A literature review was conducted through a methodical search on the Pubmed and Embase databases. The evaluation of lymph node metastases represents a critical phase in the staging and follow-up of melanoma patients. Therefore, a thorough knowledge of the imaging methods available and the interactions between the clinician and the radiologist are essential for making the correct choice for individual patients, for a better management, and to improve treatment and survival.
Effect of Sleep Disturbance on Cognitive Function in Elderly Individuals: A Prospective Cohort Study
Authors: Kim Dong-Kyu , Lee Il Hwan , Lee Byeong Chan , Lee Chang Youl
Published: June 2022

Many epidemiologic and clinical studies have shown significant links between the degree of sleep disturbance and severity of impairment of selective cognitive functions, including the risk of neurodegenerative diseases. However, the sleep parameters that affect cognitive function in old age are unclear. Therefore, we investigated the association between sleep parameters and cognitive function in older patients. Patients aged above 65 years who complained of sleep-disordered breathing were enrolled consecutively. The Mini-Mental-State Examination tool was used to evaluate cognitive function. Eighty patients (normal cognitive function, n = 32 and cognitive impairment, n = 42) were included in this study. Multiple linear regression and binary logistic regression analyses were performed to explain the relationship between sleep parameters and cognitive function. We found that the body mass index (BMI) was significantly lower in the cognitive impairment group than in the normal cognitive function group. Additionally, the cognitive impairment group showed significantly decreased sleep efficiency and an increased apnea index compared with normal subjects. Moreover, lower BMI, reduced sleep efficiency, and high frequency of apnea events during sleep were associated with an increased risk of cognitive impairment.
ORIFICE (Interventional Radiotherapy for Face Aesthetic Preservation) Study: Results of Interdisciplinary Assessment of Interstitial Interventional Radiotherapy (Brachytherapy) for Periorificial Face Cancer
Authors: Tagliaferri Luca , Giarrizzo Ilaria , Fionda Bruno , Rigante Mario , Pagliara Monica Maria , Casà Calogero , Parrilla Claudio , Lancellotta Valentina , Placidi Elisa , Salvati Alessandra , Macchia Gabriella , Gentileschi Stefano , Blasi Maria Antonietta , Morganti Alessio Giuseppe , Bussu Francesco , Peris Ketty , Paludetti Gaetano , Valentini Vincenzo
Published: June 2022

(1) Background: Periorificial face cancer (PFC), defined as both squamous cell carcinoma (SCC) and basal cell carcinoma (BCC) arising around the eyelids, the nose vestibule and the lips, has very high incidence rates worldwide. The aim of our retrospective analysis, focusing on local control (LC) and patients’ degree of satisfaction with the cosmetic outcome, is to present the results of a single institutional series of patients affected by PFC and treated by interventional radiotherapy (brachytherapy–IRT). (2) Methods: We retrospectively evaluated patients affected by PFC who were treated at our Interventional Oncology Center (IOC) with interstitial IRT from 2012 to 2021 with doses and volumes specific for each subsite considered. (3) Results: We report the results of 40 patients affected by PFC and treated by HDR interstitial IRT. The median follow-up was 24 months. The actuarial 3-year LC was 94%. Regarding patients’ satisfaction, we found that 93% of patients were satisfied and only 7% of patients were not completely satisfied with the final cosmetic result. (4) Conclusions: Interstitial HDR IRT could be an effective therapeutic option providing adequate disease control and preventing potentially disfiguring surgical approaches. More numerous and standardized studies are warranted to confirm the available evidence.
Suppressors of Cytokine Signaling Are Decreased in Major Depressive Disorder Patients
Authors: Kobayashi Nobuyuki , Shinagawa Shunichiro , Nagata Tomoyuki , Shigeta Masahiro , Kondo Kazuhiro
Published: June 2022

There is strong evidence for an association between major depressive disorder (MDD) and inflammation. However, some studies have not observed an increase in inflammatory cytokines in MDD, and the mechanism behind this is unknown. In the present study, we evaluated MDD severity using the Montgomery–Åsberg Depression Rating Scale (MADRS) and quantified mRNA levels of the blood inflammatory cytokines interleukin (IL) 1β, IL-6 and tumor necrosis factor alpha (TNF-α), as well as negative regulators of cytokine signaling—comprising IL-10, IL-1RA, SOCS1, SOCS2 and SOCS3—in MDD patients (n = 36), with a focus on mild MDD, and normal controls (NC, n = 30). We also measured the serum levels of IL-1β and IL-6. Neither the blood mRNA nor the protein levels of inflammatory cytokines were significantly elevated in the MDD group compared with the NC group. However, we observed significant decreases in SOCS1, SOCS2 and SOCS3 mRNA in the MDD group compared to the NC group. A significant finding was a decrease in SOCS3 mRNA after remission from MDD, suggesting that SOCS3 is a trait marker in depressive symptoms. We consider that our findings would be useful in elucidating the pathophysiological mechanism of depression.
Individualized Wound Closure—Mechanical Properties of Suture Materials
Authors: Polykandriotis Elias , Daenicke Jonas , Bolat Anil , Grüner Jasmin , Schubert Dirk W. , Horch Raymund E.
Published: June 2022

Wound closure is a key element of any procedure, especially aesthetic and reconstructive plastic surgery. Therefore, over the last decades, several devices have been developed in order to assist surgeons in achieving better results while saving valuable time. In this work, we give a concise review of the literature and present a biomechanical study of different suturing materials under mechanical load mimicking handling in the operating theatre. Nine different suture products, all of the same USP size (4-0), were subjected to a standardized crushing load by means of a needle holder. All materials were subjected to 0, 1, 3 and 5 crushing load cycles, respectively. The linear tensile strength was measured by means of a universal testing device. Attenuation of tensile strength was evaluated between materials and between crush cycles. In the pooled analysis, the linear tensile strength of the suture materials deteriorated significantly with every cycle (p < 0.0001). The suture materials displayed different initial tensile strengths (in descending order: polyglecaprone, polyglactin, polydioxanone, polyamid, polypropylene). In comparison, materials performed variably in terms of resistance to crush loading. The findings were statistically significant. The reconstructive surgeon has to be flexible and tailor wound closure techniques and materials to the individual patient, procedure and tissue demands; therefore, profound knowledge of the physical properties of the suture strands used is of paramount importance. The crushing load on suture materials during surgery can be detrimental for initial and long-term wound repair strength. As well as the standard wound closure methods (sutures, staples and adhesive strips), there are promising novel devices.
Fetal Doppler Evaluation to Predict NEC Development
Authors: Duci Miriam , Cosmi Erich , Zorzato Pierpaolo , Londero Ambrogio Pietro , Verlato Giovanna , Baraldi Eugenio , Ragazzi Eugenio , Fascetti Leon Francesco , Visentin Silvia
Published: June 2022

Antenatal factors play a role in NEC pathogenesis. This study aimed to investigate the predictive value of fetal ductus venosus doppler (DV) for NEC in fetal growth restriction fetuses (FGRF) and to assess the predictive accuracy of IG21 and Fenton curves in NEC development. Data from FGRF, postnatal findings, and Doppler characteristics were collected between 2010 and 2020 at a single center. Patients were then divided into two groups (i.e., with and without NEC). Bivariate and multivariate analyses were performed. We identified 24 cases and 30 controls. Absent or reversed end-diastolic flow (AREDF) and increased resistance in the DV were more impaired in cases (p < 0.05). Although the median birthweight was not different, the Fenton z-score was lower in NEC (p < 0.05). Fetal cardiopulmonary resuscitation, synchronized intermittent mandatory ventilation, neonatal respiratory distress, persistent patent ductus arteriosus (PDA), and inotropic support were more frequent in the NEC group. Furthermore, NEC patients had lower white blood cells (WBC) (p < 0.05). The predictive model for NEC (model 4), including Fenton z-score, WBC, PDA, and DV had an AUC of 84%. Fetal Doppler findings proved effective in predicting NEC in FGR. The Fenton z-score was the most predictive factor considering the fetal growth assessment showing high sensitivity.
STAT3 and NTRK2 Genes Predicted by the Bioinformatics Approach May Play Important Roles in the Pathogenesis of Multiple Sclerosis and Obsessive–Compulsive Disorder
Authors: Sepehrinezhad Ali , Shahbazi Ali , Bozorgmehr Ali , Kateb Babak , Yamamoto Vicky , Negah Sajad Sahab
Published: June 2022

Background: There are no data available on the levels of genetic networks between obsessive–compulsive disorder (OCD) and multiple sclerosis (MS). To this point, we aimed to investigate common mechanisms and pathways using bioinformatics approaches to find novel genes that may be involved in the pathogenesis of OCD in MS. Methods: To obtain gene–gene interactions for MS and OCD, the STRING database was used. Cytoscape was then used to reconstruct and visualize graphs. Then, ToppGene and Enrichr were used to identify the main pathological processes and pathways involved in MS-OCD novel genes. Additionally, to predict transcription factors and microRNAs (miRNAs), the Enrichr database and miRDB database were used, respectively. Results: Our bioinformatics analysis showed that the signal transducer and the activator of transcription 3 (STAT3) and neurotrophic receptor tyrosine kinase 2 (NTRK2) genes had connections with 32 shared genes between MS and OCD. Furthermore, STAT3 and NTRK2 had the greatest enrichment parameters (i.e., molecular function, cellular components, and signaling pathways) among ten hub genes. Conclusions: To summarize, data from our bioinformatics analysis showed that there was a significant overlap in the genetic components of MS and OCD. The findings from this study make two contributions to future studies. First, predicted mechanisms related to STAT3 and NTRK2 in the context of MS and OCD can be investigated for pharmacological interventions. Second, predicted miRNAs related to STAT3 and NTRK2 can be tested as biomarkers in MS with OCD comorbidity. However, our study involved bioinformatics research; therefore, considerable experimental work (e.g., postmortem studies, case–control studies, and cohort studies) will need to be conducted to determine the etiology of OCD in MS from a mechanistic view.
Surviving Black Swans: The Challenge of Market Timing Systems
Authors: Topiwala Pankaj , Dai Wei
Published: June 2022

It is an open secret that most investment funds actually underperform the market. Yet, millions of individual investors fare even worse, barely treading water. Algorithmic trading is now so common, it accounts for over 80% of all trades and is the domain of professionals. Can it also help the small investor? Individual investors are advised to buy-and-hold an index fund or a balanced portfolio including stocks, bonds, and cash equivalents. That would ensure market performance. However, market indices also occasionally have deep drawdowns (such as the devastating market crash of 1929 and other so-called Black Swan events). In contrast to received wisdom, we argue with evidence from backtesting on major U.S. market indices, as well as some select stocks that simple ideas in rule-based market timing can in fact be useful. One can not only obtain good results, but outperform market indices, while, at the same time, reducing deep drawdowns, surviving Black Swan events.
Valuing Collaborative Synergies with Real Options Application: From Dynamic Political Capabilities Perspective
Authors: Čirjevskis Andrejs
Published: June 2022

This paper aims to justify propositions that the dynamic political capabilities of collaborative partners to manage their institutional contexts are important drivers of collaborative synergies which can be valued by real options. To date, the institutional context of collaborative corporate strategies (strategic alliances, mergers, and acquisitions), particularly the analysis of the influence of government agencies on the synergies or unrealized synergies of collaborative ventures, remains unexplored. Moreover, the interdependence between the institutional dimensions of the collaborative strategies, the dynamic political capabilities of the collaborating partners, and collaborative synergies are needed to be integrated into new conceptual models and a new framework. This paper contributes to this request by providing a cohesive framework of micro-foundations with dynamic political capabilities and demonstrating an application of simple and compound sequentially combined real options for collaborative synergies’ valuation in the findings and discussion section. This paper makes several theoretical and empirical contributions to international business, strategic management, and corporate finance. The practical implication of the research is evidence that food retailers who want to grow with the latest consumer trends will need dynamic political capabilities to deal with the impact of an institutional context. Finally, this paper discusses research limitations and future work.
The Impact of Offline Service Effort Strategy on Sales Mode Selection in an E-Commerce Supply Chain with Showrooming Effect
Authors: Wang Xiangsheng , Chaolu Temuer
Published: June 2022

In practice, several e-commerce platforms offering online channels not only act as resellers but also serve as the marketplace. However, the existing literature rarely explores the impact of the offline service effort strategy with the showrooming effect on the platform’s optimal sales mode. Considering a supply chain consisting of a manufacturer and a platform, we examine the interplay between the manufacturer’s offline service effort strategy and the platform’s online sales modes. We derive conditions under which each of the four scenarios (adopting the service effort strategy under the agency or reselling modes, not adopting the service effort strategy under the agency or reselling modes) emerges in equilibrium. Our results show that the service effort strategy with the showrooming effect can induce the platform’s sales mode selection. Specifically, when the referral fee is low and the showrooming effect is moderate, the platform may choose the agency mode instead of the reselling mode, while when the referral fee is sufficiently high and the showrooming effect is moderate, the platform may adopt the reselling mode instead of the agency mode. Furthermore, when the competition intensity and showrooming effect are sufficiently small, the service effort strategy will be beneficial to the manufacturer and the platform, creating a win-win situation. When the competition intensity or showrooming effect is sufficiently large, the service effort strategy may cause a prisoner’s dilemma for the manufacturer and the platform. In addition, the supply chain consisting of a manufacturer, an offline store and an online platform is also studied in the extension section, and we find that our main results are valid.
Forests, Fields, and Pastures: Unequal Access to Brazil Nuts and Livelihood Strategies in an Extractive Reserve, Brazilian Amazon
Authors: Ubiali Bruno , Alexiades Miguel
Published: June 2022

This article examines access to an economically important forest product (Brazil nuts) and its relationship with livelihood strategies in the Cazumbá–Iracema Extractive Reserve (CIER), Acre, Brazil. The objective is twofold: (i) to clarify how social mechanisms regulating access to Brazil nuts operate and (ii) to analyse the relationship between differential access to Brazil nuts and livelihood diversification in terms of cash income. For this, we conducted 55 semi-structured interviews with household heads in three rubber tapper (seringueiro) communities. Our findings indicate that Brazil nuts are important to seringueiro livelihoods, although both access to Brazil nuts and livelihood strategies are highly variable between households and communities. Limited access to Brazil nuts is partly overcome through informal arrangements and investment in wage labour, swidden agriculture, and cattle raising, as part of highly diversified livelihood portfolios. However, restrictions to agriculture and cattle raising generate considerable tensions between many seringueiros and environmental managers. We highlight the importance of viewing livelihood diversification and adaptability as important components of the long-term viability of the extractive reserve model, particularly in the context of the growing uncertainties and risks associated with accelerating climate and socio-environmental change as well as amidst ongoing political dynamics in Brazil.
Securing Land and Water for Food Production through Sustainable Land Reform: A Nexus Planning Perspective
Authors: Nhamo Luxon , Mpandeli Sylvester , Liphadzi Stanley , Mabhaudhi Tafadzwanashe
Published: June 2022

Land and water are vital resources for sustaining rural livelihoods and are critical for rural development as they form the basis of agriculture, the main economic activity for rural communities. Nevertheless, in most developing countries, land and water resources are unevenly distributed due to historical and socio-economic imbalances, hence the need for land reform policies to address these disparities. However, redistributing land without considering the interconnectedness of land and socio-ecological systems can compound existing food and water insecurity challenges. This study used a mixed research method, integrating both quantitative and qualitative data, to develop a framework to guide policy and decision-makers to formulate coherent strategies towards sustainable land redistribution programmes and achieve the desired outcomes. The approach was vital for integrating the broad and intricate interlinkages between water, land, and environmental resources. Therefore, the framework is based on transformative and circular models for informing strategic policy decisions towards sustainable land redistribution. The focus was on South Africa’s land redistribution plans and the implications on water and food security and rural development. The developed framework is designed to ensure the sustainability of agrarian reform and rural economic development. It is framed to address land and water accessibility inequalities, promote water and food security, and enhance rural development. A sustainable land redistribution increases the adaptive capacity of rural communities to climate change, enhances their resilience, and provides pathways towards Sustainable Development Goals (SDGs).