bluuebunny/crossref_metadata_2025 huggingface dataset:
A discrete element method to model coating layer mechanical properties with bimodal and pseudo-full particle size distributions
Authors: VARNEY DANIEL , TOIVAKKA MARTTI , BOUSFIELD DOUGLAS W.
Published: August 2023

The mechanical properties of paper coating layers are important in converting operations such as calendering, printing, and folding. While several experimental and theoretical studies have advanced our knowledge of these systems, a particle level understanding of issues like crack-at-the-fold are lacking. A discrete element method (DEM) model is used to describe bending and tension deformations of a coating layer. The particles in the model are either bimodal distributions or pseudo-full particle size distributions of spherical particles. The impact of particle size distribution on the predicted mechanical properties of the coating layer is reported. Inputs to the model include properties of the binder film and the binder concentration. The model predicts crack formation as a function of these parameters and also calculates the modulus, the maximum stress, and the strain-to-failure. The simulation results are compared to previous experimental results. Reasonable predictions were obtained for both tensile and bending for a range of latex-starch ratios and at various binder concentrations. The influence of particle packing density on mechanical properties is reported.
A Statistical Analysis of Positive Excess Mortality at Covid-19 in 2020-2021
Authors: Raihen Md Nurul , Akter Sultana , Tabassum Fariha , Jahan Farjana , Sardar Md Nazmul
Published: August 2023

When it comes to making assessments about public health, the mortality rate is a very important factor. The COVID-19 pandemic has exacerbated well-known biases that affect the measurement of mortality, which varies with time and place. The COVID-19 pandemic took the world off surveillance, and since the outbreak, it has caused damage that many would have thought unthinkable in the present era. By estimating excess mortality for 2020 and 2021, we provide a thorough and consistent evaluation of the COVID-19 pandemic's effects. Excess mortality is a term used in epidemiology and public health to describe the number of fatalities from all causes during a crisis that exceeds what would be expected under 'normal' circumstances. Excess mortality has been used for thousands of years to estimate health emergencies and pandemics like the 1918 "Spanish Flu"6. Positive excess mortality occurs when actual deaths exceed previous data or recognized patterns. It could demonstrate how a pandemic affects the mortality rate. The estimates of positive excess mortality presented in this research are generated using the procedure, data, and methods described in detail in the Methods section and briefly summarized in this study. We explored different regression models in order to find the most effective factor for our estimates. We predict the pandemic period all-cause deaths in locations lacking complete reported data using the Poisson, Negative Binomial count framework. By overdispersion test, we checked the assumption of the Poisson model, and then we chose the negative binomial as a  good fitting model for this analysis through Akaike Information Criteria (AIC) and Standardized residual plots, after that checking the P-value<0.05; we found some significant predictors from our choosing model Negative binomial model, and the coefficient of all predictors gave the information that some factors have a positive effect, and some has a negative effect at positive excess mortality at COVID-19 (2020-2021).
Projekty NFT i bariery ich wejścia na rynek
Authors: Ostrowski Sławomir , Molenda Krzysztof
Published: August 2023

Niniejsza praca traktuje o barierach wejścia na rynek dla projektów NFT. Porusza zagadnienia związane z kapitałochłonnością, regulacjami prawnymi, dostępem do wiedzy i patentów, a także ze zróżnicowaniem produktów i dostawców na rynku NFT. Celem pracy jest identyfikacja i opis barier wejścia, które napotykają nowe przedsiębiorstwa wchodzące na rynek. Autorzy przewidują, że wraz z rosną[1]cym zainteresowaniem konsumentów wzrośnie zainteresowanie uruchomieniem projektów NFT przez przedsiębiorców, którzy będą mogli wykorzystać przedstawione wyniki, aby usprawnić swój proces wejścia z projektem NFT na rynek. Pierwszym etapem pracy jest wprowadzenie w podjętą problematykę, w którym autorzy wyjaśniają technologię blockchain oraz przedstawiają zarys sytuacji panującej na rynku NFT, która była motywacją do powstania niniejszego artykułu. W kolejnej części, bazując na studiach przypadków, autorzy omawiają pięć barier wejścia na rynek projektów NFT. W końcowej części natomiast przedstawione są wnioski, na podstawie których autorzy stwierdzają, że bariery wejścia na rynek NFT są małe i atrakcyjne dla przedsiębiorców, co wraz z napływem nowych konsumentów może wskazywać na rosnącą w niedalekiej przyszłości liczbę nowych projektów wypuszczanych na badany rynek.
Tendencias en la formación y praxis médicas en Colombia
Authors: Estrada-Mesa Diego Alejandro , Cardona-Arias Jaiberth Antonio , Jaramillo-Caro Ana María
Published: August 2023

En la formación en medicina existen múltiples textos sobre el futuro de la disciplina, la mayoría realizan la prospectiva a partir de temáticas específicas como las limitaciones en el conocimiento fisiopatológico, etiológico o terapéutico de algunas enfermedades, los usos de la investigación científica, la articulación con las ingenierías y el desarrollo tecnológico, la necesidad de una enseñanza y praxis que vincule los desarrollos científicos con consideraciones éticas y humanistas, entre otros. Sin embargo, son poco analizadas las tendencias de la formación y praxis médica con base en teorías de mayor amplitud o alcance; por ello, este ensayo describe brevemente tres cuerpos teóricos que resultan útiles para pensar el presente y futuro de la medicina, estos son: la medicina basada en la evidencia y centrada en la persona, las humanidades médicas y los determinantes sociales de la salud, como tres grupos de teorías sólidas para la formación y praxis médicas en Colombia.
РОЗВИТОК ТРАДИЦІЙ МУЗИЧНО-ЕСТЕТИЧНОГО ВИХОВАННЯ ПІДРОСТАЮЧОГО ПОКОЛІННЯ В УКРАЇНІ ЗАСОБАМИ ХОРОВОГО СПІВУ
Authors: Сбітнєва Олена , Заверуха Олена
Published: August 2023

У статті досліджуються розвиток традицій музично-естетичного виховання підростаючого покоління в Україні засобами хорового співу. Автори статті зазначають, що з давніх часів хоровий спів був невід’ємним елементом суспільного життя. У стародавніх державах його використовували як засіб не лише розваги й ритуального дійства, а й гармонізації людських стосунків на різних рівнях. Водночас, починаючи з раннього середньовіччя, протягом багатьох століть хоровий спів виконував переважно прикладну роль у суспільстві – його використовували як засіб проведення церковних літургій, релігійного, морального й патріотичного виховання. Поступове збагачення філософських і психолого-педагогічних уявлень про функціональне й зокрема естетично-виховне значення музики для окремої особистості й усього суспільства, що розпочалось ще з епохи Відродження, до кінця ХІХ століття практично не впливало на реальний стан виховання учнів у загальноосвітніх навчальних закладах. Підкреслено, що тільки на межі ХІХ−ХХ століть теорія музично-естетичного виховання дітей і молоді суттєво наблизилася до реальної практики. Водночас, разом з усвідомленням педагогічною спільнотою необхідності гармонійного й усебічного розвитку особистості з раннього віку та особливої ролі в цьому музично-естетичного виховання засобами різноманітної активності дитини, хоровий спів поступово втратив своє значення як домінантний вид музичної діяльності дітей у процесі шкільної освіти. Автори статті зазначають, що проблема використання різноманітного виховного потенціалу хорового співу в умовах шкільної освіти залишається актуальною у вітчизняній педагогіці, фахівці наголошують, що хоровий спів разом з іншими видами музичної діяльності є важливим і невід’ємним засобом музично-естетичного виховання молодого покоління.
Quantification of measurable residual disease using duplex sequencing in adults with acute myeloid leukemia
Authors: Dillon Laura W. , Higgins Jake , Nasif Hassan , Othus Megan , Beppu Lan , Smith Thomas H. , Schmidt Elizabeth , Valentine III Charles C. , Salk Jesse J. , Wood Brent L , Erba Harry P. , Radich Jerald P. , Hourigan Christopher S.
Published: August 2023

The presence of measurable residual disease (MRD) is strongly associated with treatment outcomes in acute myeloid leukemia (AML). Despite the correlation with clinical outcomes, MRD assessment has yet to be standardized or routinely incorporated into clinical trials and discrepancies have been observed between different techniques for MRD assessment. In 62 patients with AML, aged 18-60 years, in first complete remission after intensive induction therapy on the randomized phase III SWOG-S0106 clinical trial (clinicaltrials gov. Identifier: NCT00085709), MRD detection by centralized, high-quality multiparametric flow cytometry was compared with a 29-gene panel utilizing duplex sequencing (DS), an ultrasensitive next-generation sequencing method that generates double-stranded consensus sequences to reduce false positive errors. MRD as defined by DS was observed in 22 (35%) patients and was strongly associated with higher rates of relapse (68% vs. 13%; hazard ratio [HR] =8.8; 95% confidence interval [CI]: 3.2-24.5; P<0.001) and decreased survival (32% vs. 82%; HR=5.6; 95% CI: 2.3-13.8; P<0.001) at 5 years. DS MRD strongly outperformed multiparametric flow cytometry MRD, which was observed in ten (16%) patients and marginally associated with higher rates of relapse (50% vs. 30%; HR=2.4; 95% CI: 0.9-6.7; P=0.087) and decreased survival (40% vs. 68%; HR=2.5; 95% CI: 1.0-6.3; P=0.059) at 5 years. Furthermore, the prognostic significance of DS MRD status at the time of remission for subsequent relapse was similar on both randomized arms of the trial. These findings suggest that next-generation sequencing-based AML MRD testing is a powerful tool that could be developed for use in patient management and for early anti-leukemic treatment assessment in clinical trials.
Minor clone of del(17p) provides a reservoir for relapse in multiple myeloma
Authors: Cui Jian , Lv Rui , Yu Tengteng , Yan Wenqiang , Xu Jingyu , Fan Huishou , Li Lingna , Liu Yuntong , Du Chenxing , Deng Shuhui , Sui Weiwei , Xu Yan , Yi Shuhua , Zou Dehui , Qiu Lugui , An Gang
Published: August 2023

The deletion of chromosome 17p (del(17p)) is considered a crucial prognostic factor at the time of diagnosis in patients with multiple myeloma (MM). However, the impact of del(17p) on survival at different clonal sizes at relapse, as well as the patterns of clonal evolution between diagnosis and relapse and their prognostic value, has not been well described. To address these issues, we analyzed the interphase fluorescence in situ hybridization (iFISH) results of 995 newly diagnosed MM (NDMM) patients and 293 patients with MM at their first relapse. Among these patients, 197 had paired iFISH data at diagnosis and first relapse. Our analysis of paired iFISH revealed that a minor clone of del(17p) at relapse but not at diagnosis was associated with poor prognosis in MM (hazard ratio for median overall survival 1.64 vs. 1.44). Fifty-six and 12 patients developed one or more new cytogenetic abnormalities at relapse, mainly del(17p) and gain/amp(1q), respectively. We classified the patients into six groups based on the change patterns in the clonal size of del(17p) between the two time points. Patients who did not have del(17p) during follow-up showed the best outcomes, whereas those who acquired del(17p) during their disease course, experienced compromised survival (median overall survival: 61.3 vs. 49.4 months; hazard ratio =1.64; 95% confidence interval: 1.06-2.56; P<0.05). In conclusion, our data confirmed the adverse impact of a minor clone of del(17p) at relapse and highlighted the importance of designing optimal therapeutic strategies to eliminate high-risk cytogenetic abnormalities (clinicaltrials gov. identifier: NCT04645199).
Humka XI (K)
sa lokaliteta Paulje: novi apsolutni datumi i poreklo najranijih nalaza
ćilibara u Srbiji
Authors: Cwaliński Mateusz , Filipović Vojislav , Bulatović Aleksandar , Kaur Sarjit , Stout Edith , Gligorić Rada
Published: August 2023

This paper presents three new absolute dates for the central grave of mound XI (K) at the Paulje necropolis in the lower Drina valley. Also, we present the results of FTIR spectroscopy for the amber finds from the 4 mounds in the necropolis, including mound XI (K). In general the results confirm the earlier assumed chronology of the site - the 14C AMS dates fit the timeframe – the central grave fits ideally the previous timeframe for the Brezjak culture, i.e. the 15th and 14th century BC, and all of the amber samples are definitely of Baltic origin. These two facts clearly suggest that the amber finds from the lower Drina could mark one of the earliest appearances of Baltic amber in the Central Balkans.
A hoard of Huşi-Vovrieşti coins from Josipovac – Selište near Osijek
Authors: Bilić Tomislav
Published: August 2023

A small hoard of Huşi-Vovrieşti coins deposited in a Danubian kantharos underneath a Late Iron Age house at the site of Josipovac – Selište near modern Osijek most likely represents a foundation deposit. As such, the cache was not meant to be retrieved, and its deposition was part of a ritual of a sort, one we cannot reconstruct with any certainty. The use of a container otherwise involved in ritualistic practises, funerary and ceremonial, perhaps also the ritual demonetisation of coins with chop-marks, as well as precise and consistent application of these chop-marks, all point to a ritualistic background to the deposition. The hoard was probably interred during the LT C1 period, i.e., during the second half of the 3rd or perhaps at the very beginning of the 2nd century BC. This date is supported by the lower chronological limit of the production of the Huşi-Vovrieşti coins, the fact that the container in which they were deposited was produced either in LT B2 or LT C1 period, with its latest possible date of usage not later than the early 2nd century BC, as well as on an analogy with the hoards of the Huşi-Vovrieşti coins deposited in the Scordiscan area that can be dated independently of this particular coin-type.
La necesidad de jueces constitucionales especializados para conocer y resolver garantías jurisdiccionales en el Ecuador
Authors: Tenecota Huerta Luis Fabián , Vázquez Martínez David Sebastián
Published: August 2023

El simple cambio de denominación para los administradores de justicia, que al conocimiento de garantías jurisdiccionales pasan a ser jueces constitucionales, ha sido un total desacierto en el Ecuador. El objetivo es promover el principio de especialidad en materia constitucional, tanto de administradores de justicia cuanto en los profesionales del derecho en general. La investigación tuvo el enfoque cualitativo basándose en la fundamentación teórica, con un alcance descriptivo explicativo para lo cual se aplicaron métodos como el inductivo-deductivo, histórico-lógico, analítico-sintético y derecho comparado. Se estableció como resultado que la falta de jueces debidamente especializados en materia constitucional vulnera los derechos a la seguridad jurídica, la tutela judicial efectiva y el debido proceso. Como aporte se estableció la necesidad imperiosa de a futuro forjar una reforma al código orgánico de la función judicial que faculte al Consejo de la Judicatura a crear unidades distritales especializadas para el conocimiento de garantías jurisdiccionales, con la selección y designación de jueces constitucionales debidamente especializados para tratar exclusivamente casos de conmoción.
Evaluation of Hysteroscopic Findings and Histopathologic Report of Endometrium in Postmenopausal Bleeding
Authors: Begum Monowara , Khatun Sabera , Begum Shirin Akter , Amatullah Mehriban , Mahmud Tasfia , Ara Rifat , Nabi Mahmud-Un , Khatoon Farhana , Nazneen Touhida , Ferdous Jannatul
Published: August 2023

Background: Women with postmenopausal bleeding have 10%-15% chance of having endometrial carcinoma and therefore the diagnostic work is aimed at excluding uterine malignancy. For accurate diagnosis of cause of postmenopausal bleeding, endometrial abnormalities can be assessed by hysteroscopy and hysteroscopy directed biopsy or fractional curettage.
Objective: To compare the hysteroscopic findings with histopathologic report of endometrium in postmenopausal bleeding.
Methods: Cross sectional study was conducted in the department of gynaecological oncology in Bangabandhu Sheikh Mujib Medical University over 1 year from June 2019 to May 2020. Thirty women with the complaints of postmenopausal bleeding were enrolled.   Each women underwent hysteroscopic evaluation and endometrial tissue was obtained by hysteroscopy directed biopsy as well as fractional curettage in some cases, then sent for histopathology. Results were analyzed to find out sensitivity, specificity, accuracy, positive predictive value and negative predictive value of hysteroscopy, taking histopathological diagnosis as gold standard. Analysis was carried out by using SPSS version 26.
Results: Hysteroscopic examination findings and histopathology of endometrium in 30 postmenopausal women, 11(36.6%) cases were found normal both on hysteroscopy and histopathology, among them 4(13.3%) cases were proliferative endometrium, 1(3.3%) was secretory endometrium and 5(16.6%) cases were found atrophic endometrium and 1(3.3%) tissue was insufficient. Hysteroscopic view of normal endometrium showed a sensitivity 100%, specificity 100%, positive predictive value 100%, negative predictive value 100% and accuracy 100%. For Endometrial polyp showed sensitivity, specificity, positive predictive value, negative predictive value   and accuracy 100%respectively. For Hyperplasia, hysteroscopy showed sensitivity 100%, specificity 96.2%, positive predictive value 80%, negative predictive value 100% and accuracy 96.7%. Endometrial carcinoma was found in 3(10%) cases and showed sensitivity of 100%, specificity of 96.3%, positive predictive value 75.0%, negative predictive value 100% and accuracy 96.7%. For the atrophic endometrium, sensitivity (100%), specificity (96.0%), positive predictive value (83.3%), negative predictive value (100%) and accuracy (96.7%). 1(3.3%) had in situ endometrial carcinoma and 2(6.6%) had adenomyosis on histopathology.
Conclusion: The study concludes that hysteroscopy and directed biopsy or fractional curettage is a highly accurate, sensitive, specific, positive predictive value and negative predictive value for diagnosis of cause of postmenopausal bleeding.
Bangladesh Medical Res Counc Bull 2023; 49(1): 1-14
G20 COMMITMENT IN THE ACHIEVEMENT OF SDG 7: OPPORTUNITIES AND CHALLENGES
Authors: Muhamad Fathun Laode , Darmastuti Shanti
Published: August 2023

Renewable energy is one of the issues that is the focus of every country, not only developed and developing countries. The energy transition is the focus of state policy in creating renewable energy. SDG 7 is one of the references for each country to oversee the energy transition policy towards renewable energy. One of the efforts made in helping each country to achieve the SDG 7 target is through international cooperation. One form of international cooperation that pays attention to renewable energy is the G20. Through the G20, it is hoped that there will be a collaboration between countries in efforts to achieve SDG 7 targets. Therefore, this article aims to analyze the opportunities and challenges faced by the G20 in implementing commitments to achieve SDGs7. Literature studies originating from official documents, journal articles, and internet sources are used to further analyze the opportunities and challenges facing the G20. The results of the study show that the G20 cooperation provides opportunities for member countries to be able to work together in achieving SDG 7, but the different characteristics and resources between developed and developing countries are a challenge in the energy transition process towards renewable energy.
Marketing mutualista como estrategia emergente. Caso de la papa durante la pandemia de Covid en 2019.
Authors: Montoya Luz Alexandra , Hernández Juan Esteban , Montoya Iván Alonso
Published: August 2023

En este documento se presentan los principales inconvenientes que tuvo la cadena de la papa en Colombia durante la pandemia y se analiza una de las soluciones aplicadas. Se estudian los mecanismos de colaboración en marketing desde la metáfora biológica, como estrategia emergente para solucionar los problemas de distribución de la cadena de la papa. Se destaca el surgimiento del virus como un evento deconstructor, en el que, además de las estrategias deliberadas, se requiere de otra emergente para solucionar los problemas económicos y de salud derivados de la situación de pandemia. Finalmente, se encuentran los elementos emergentes que favorecieron esta situación y se proponen algunos factores para fortalecer el marketing mutualista como alternativa, en un evento deconstructor.
Intrahepatic Splenosis in a Patient with Autoimmune Hepatitis with No History of Splenectomy or Abdominal Trauma
Authors: Aono Keiya , Suzuki Takahiro , Hattori Masaoki , Yoshihara Motoi
Published: August 2023

Splenosis should be suspected when a patient has a history of trauma or abdominal surgery. Intrahepatic splenosis is a rare disease that is often difficult to distinguish from liver malignancy, especially hepatocellular carcinoma. The cause of intrahepatic splenosis may be though the auto-transplantation of splenic tissue on the surface of the liver. The authors report a case of intrahepatic splenosis that presented as a liver tumour in an 81-year-old female treated for autoimmune hepatitis, who had no history of splenectomy or abdominal trauma. Laparoscopic hepatectomy was performed and the specimen demonstrated characteristic histopathological findings of the spleen. Only one case of a patient who had no history of splenectomy or abdominal trauma has been reported in the literature. It may be hypothesised that erythropoiesis induced by local hypoxia in the chronic hepatitis may cause the growth of splenic erythrocytic progenitor cells, which have migrated via portal vein to the liver.
A Study on ‘Media Helden’, an Adolescent Cyberbullying Prevention Program in Germany: Focusing on Empathy Improvement Program
Authors:   The Korean Society of Culture and Convergence, Jung Younghee
Published: August 2023

This paper examines Media Helden, an adolescent cyberbullying prevention program in Germany, as a solution to increasingly serious adolescent cyberbullying. The goal of the Media Helden program is to lead to reduction of victims and perpetrators as well as prevention of cyberbullying through empathy enhancement. Through role-playing, students practice and train their empathy skills by focusing on their actions and their changes as bystanders, rather than focusing only on the role of perpetrator-victim in a cyberbullying situation. Adolescent cyberbullying is not an individual problem, but occurs when social power is misused in social relationships. It is hoped that this program will spread awareness that cyberspace is also a social space with ethics and rules, and become a solution to prevent cyberbullying among adolescent.
KORELASI ANTARA PENGUASAAN KOSAKATA DAN KEMAMPUAN BERBICARA MAHASISWA POLITEKNIK NEGERI MALANG
Authors: Widiyowati Eny , Suyono Achmad , Suryanto Bambang
Published: August 2023

Kemampuan berbicara mahasiswa dalam bahasa asing – dalam hal ini bahasa Jepang – menjadi salah satu tolok ukur keberhasilan mahasiswa tersebut dalam menguasai bahasa Jepang. Penguasaan kosakata menjadi komponen penting untuk menguasai keterampilan berbicara. Penelitian ini merupakan penelitian deskriptif kuantitatif yang bertujuan untuk mengetahui korelasi antara penguasaan kosakata dan kemampuan berbicara bahasa Jepang mahasiswa Jurusan Administrasi Niaga Politeknik Negeri Malang. Populasi pada penelitian ini adalah mahasiswa Program Studi D-III Administrasi Bisnis Jurusan Administrasi Niaga Politeknik Negeri Malang kelas IIA, IIB, dan IIC semester 4. Teknik pengambilan sampel menggunakan teknik sampling jenuh dengan jumlah sampel sebanyak 83 responden. Teknik pengumpulan data menggunakan instrumen berbetuk tes tertulis dan wawancara. Analisis data menggunakan uji statistik korelasi Pearson (Product Moment Correlation). Uji statistik korelasi Pearson menghasilkan koefisien korelasi sebesar 0,612. Nilai ini menunjukkan adanya korelasi yang positif dan signifikan antara penguasaan kosakata dan kemampuan berbicara bahasa Jepang mahasiswa Jurusan Administrasi Niaga Politeknik Negeri Malang. Hasil penelitian juga menunjukkan responden belum menguasai bentuk lampau kopula dan kata kerja bahasa Jepang.
PENERAPAN PEMBELAJARAN KOOPERATIF MODEL NUMBER HEAD TOGETHER UNTUK MENINGKATKAN MOTIVASI DAN HASIL BELAJAR MATA KULIAH BAHASA INGGRIS
Authors: Imron Aly , Mujianto  , Ratnawati Yani
Published: August 2023

Metode belajar mengajar Numbered Heads Together berhubungan dengan banyak siswa untuk memeriksa pemahaman siswa tentang materi ajar. Metode ini memiliki beberapa prosedur yang diterapkan secara eksplisit untuk memberikan waktu yang cukup untuk berpikir, menjawab, dan saling membantu antar anggota dalam kelompok dan diharapkan dalam proses pembelajaran dapat meningkatkan hasil belajar yang lebih baik. Tujuannya adalah untuk mengetahui peningkatan motivasi belajar siswa dan hasil belajar siswa melalui penerapan pembelajaran kooperatif metode Numbered Heads Together pada mata pelajaran bahasa Inggris. Penelitian eksperimental ini menggunakan rancangan Penelitian Tindakan Kelas dengan menerapkan pendekatan kualitatif serta dilaksanakan dalam dua siklus yang meliputi perencanaan, pelaksanaan tindakan, observasi, dan refleksi. Hasil perbandingan siswa antara siklus I dan siklus II signifikan dan meningkat tajam, artinya siklus II cukup baik dilihat dari motivasi belajar siswa yang terdiri dari Minat (57,33%; 88)%, Konsentrasi (62,67%; 92%), perhatian (56%; 85,33%), ketekunan (61,33%; 87,33%). Peningkatan rata-rata sebesar 26% dari siklus pertama ke siklus kedua.
PENGARUH ORIENTASI BELANJA DAN PERBEDAAN GENDER TERHADAP PENCARIAN INFORMASI ONLINE DAN BELANJA ONLINE PADA MAHASISWA JURUSAN ADMINISTRASI NIAGA POLITEKNIK NEGERI MALANG
Authors: Sudjanarti Dwi , Istining Wardani Tri , Khabibah Umi
Published: August 2023

Penelitian ini bertujuan untuk mengetahui pengaruh orientasi belanja terhadap pencarian informasionlinedan belanjaonline, serta perbedaan laki-laki dan perempuan dalam orientasi belanja.Jenis penelitian yang digunakandalam penelitian ini adalah penelitian kuantitatif dengan jenis deskriptif kausal. Populasi penelitian adalah mahasiswaJurusan Administrasi Politeknik Negeri Malang Tahun Akademik 2017/2018 yang pernah melakukan pembelianonline.Pengumpulan data menggunakan kuesioner kepada 94 responden menggunakan teknikpurposive random sampling.Analisisdata menggunakan regresi sederhana untuk mengetahui pengaruh orientasi belanja terhadap pencarian informasionlinedanbelanjaonline, kemudian dilanjutkan dengan ujiindependent sample T testuntuk melihat perbedaan laki-laki dan perempuandalamorientasi belanja.Hasil penelitian menunjukkan bahwa orientasi belanja tidak berpengaruh terhadap pencarianinformasionlinedengan t hitung 0,547 < t tabel 1,66159. Orientasi belanjaberpengaruh terhadap belanjaonlinedengan t hitung 2,609 > t tabel 1,66159. Persamaan regresi sederhana yang didapatkan yaitu Y1= 7,898 + 0,013 X dan Y2= 2,492 + 0,082 X.Hasil penelitian menunjukkan bahwa tidak ada perbedaan orientasi belanja atara laki-laki dan perempuan.
PENGARUH PENGEMBANGAN KARIER TERHADAP KEPUASAN KERJA KARYAWAN PADA RITEL ALFA MART DI MALANG
Authors: Nur Aini Lilis , Kristianingsih Tatiana , Nurtjahjani Fullchis
Published: August 2023

Penelitian ini mengambil tema faktor penentu kepuasan kerja. Dalam penelitian ini diambil sampel 50orang sebagai karyawan Alfamart. Studi kuantitatif di mana responden diperoleh dari kuesioner yang dibagikan digunakansebagai data primer diolah dengan SPSS. Respon responden menilai rentang 1-5, dengan skala likert sangat tidak setujuhingga sangat setuju. Berdasarkan hasil penelitian, dari uraian data mayoritas responden berjenis kelamin laki-laki denganusia dibawah 25 tahun. Uji coba yang dilakukan adalah uji validitas dan reliabilitas yaitu uji validitas kuesioner yangdibagikan, uji t untuk menguji kebenaran hipotesis yang dirumuskan, uji korelasi dan regresi untuk menguji hubungan danpengaruh hubungan dan pengaruh masing-masing variabel segmentasi pasar hubungan konsumen yang merupakanpengembangan karir. Pada uji coba yang dilakukan terdapat kebenaran hipotesis yang dirumuskan yaitu terdapat hubunganyang signifikan antara faktor pengembangan karir dengan kepuasan kerja.
THE ROLE OF INFORMATION TECHNOLOGY (IT) IN KNOWLEDGE MANAGEMENT PROCESS AT BUSINESS ADMINISTRATION DEPARTMENT LECTURERS, STATE POLYTECHNIC OF MALANG
Authors: Rachmi Asminah , Istining Wardani Tri , DS Susilowati Kartika
Published: August 2023

The role of universities in providing knowledge and learning in various scientific disciplines has positioned universities as knowledge-based organizations. This suggests that universities have an important level of knowledge management (KM) activity although they may not have formal KM practices. This study aims to investigate the knowledge management process with its various dimensions namely knowledge creation, acquisition, organization, sharing and implementation in the Business Administration Department State Polytechnic of Malang. It also to identify the use of IT (hardware, software, security and usability) including the impotance of IT in supporting KM process to increase the competitiveness of Business Administration Department, Malang State Polytechnic. This research is qualitative research using case study approach. The research subject is Business Administration Department, State Polytechnic of Malang. Unit analyses are head of Department, secretary of department, head of study program, lecturers and administratif staffs. Data collection methods use interview, observation, and document analysis. Data analysis use within case analysis. The research findings showed that activities held by the Business Administration Department are in accordance with a knowledge management system such as capture, store, change and share knowledge from the department to other members of the organization. The IT components including hardware, software, intranet, and internet networks as well as integrated applications facilitate all the activities. Suggestions were provided related to updating IT that should be conducted regularly including increasing internet network capacity to support knowledge management process that will increase organization performance.
PENGARUH KESADARAN MEREK, KUALITAS PRODUK DAN HARGA TERHADAP KEPUTUSAN PEMBELIAN PASTA GIGI
Authors: Basuki R Sugeng , Rulirianto  , Kusumasasti Ika
Published: August 2023

Pepsodent merupakan salah satu produk pasta gigi dengan brand yang sangat dikenal oleh konsumen. Pepsodent adalah pasta gigi pertama di Indonesia yang meluncurkan pasta gigi berflorida pada tahun 1980-an dan satusatunya pasta gigi di Indonesia yang secara aktif mendidik dan mempromosikan kebiasaan menyikat gigi secara benar melalui program sekolah dan layanan pemeriksaan gigi gratis. Sejak itu Pepsodent telah melengkapi jajaran produknya mulai dari pembersihan dasar hingga pasta gigi dengan manfaat lengkap. Pada tahun 2005 Pepsodent merupakan satu-satunya merek pasta gigi yang diakui oleh FDI, Federasi Gigi Dunia, di samping asosiasi dokter gigi di dalam negeri. Pepsodent terdiri dari berbagai macam pilhan rasa dan fungsi. PT Unilever Indonesia berusaha untuk selalu melakukan inovasi agar tetap menarik perhatian konsumen dan konsumen tidak berpindah ke merek lain serta konsumen tetap menjaga loyalitasnya. Terbukti bahwa untuk periode tahun 2019, Pepsodent menduduki urutan pertama dengan persentase sebesar 68,3% untuk berbagai jenis pasta gigi.
SOSIAL MEDIA MARKETING SEBAGAI STRATEGI DESTINATION MARKETING ORGANISATIONS DALAM RE-BRANDING KAJOETANGAN HERITAGE
Authors: Lestari Baroroh , Rifiani Permatasari Ita , Eka Wahyu Ellyn
Published: August 2023

Kampung Kajoetangan merupakan salah satu destinasi wisata yang saat ini sedang berusaha dikembangkan di Kota Malang. Pada masa kolonial, kampung Kajoetangan dikenal sebagai tempat bisnis dan pertokoan. Saat ini, kampung Kajoetangan melakukan re-branding untuk menjadi destinasi wisata sejarah. Oleh karena itu, maka penelitian ini bertujuan untuk 1) Merumuskan dan mengembangkan serta mengimplementasikan model Destination Marketing Organization (DMO) yang efektif untuk media sosial twitter di Kampoeng Kajoetangan Heritage Malang dengan melibatkan masyarakat, instansi pemerintah dan akademisi. 2) Mengusulkan model DMO kepada pemerintah daerah Kota Malang sebagai Lembaga untuk memasarkan Kampoeng Kajoetangan Heritage Malang. 3) Mendesain social media twitter dan video promosi yang inovatif dan komunikatif sebagai Strategi DMO dalam Re-branding Kampoeng Kajoetangan Heritage. Dalam mencapai tujuan tersebut, digunakan metode kualitatif. Data dikumpulkan dari sumber sekunder dan primer. Data primer dikumpulkan dari wawancara, diskusi kelompok terfokus dan observasi langsung. Dalam proses analisis data, digunakan metode deskriptif. Hasil penelitian menunjukkan bahwa Kampung Kajoetangan Heritage memiliki potensi sumberdaya wisata sejarah yang melimpah. Sumber daya wisata sejarah tersebut dapat dikelompokkan menjadi 5 sektor pariwisata. Orisinalitas penelitian: Identifikasi dan temuan penelitian yang dikembangkan dapat membantu pengelola Kampung Kajoetangan Heritage dalam pengelolaan destinasi yang berkelanjutan.
Spf1 and Ste24: quality controllers of transmembrane protein topology in the eukaryotic cell
Authors: Tipper Donald J. , Harley Carol A.
Published: August 2023

DNA replication, transcription, and translation in eukaryotic cells occur with decreasing but still high fidelity. In contrast, for the estimated 33% of the human proteome that is inserted as transmembrane (TM) proteins, insertion with a non-functional inverted topology is frequent. Correct topology is essential for function and trafficking to appropriate cellular compartments and is controlled principally by responses to charged residues within 15 residues of the inserted TM domain (TMD); the flank with the higher positive charge remains in the cytosol (inside), following the positive inside rule (PIR). Yeast (Saccharomyces cerevisiae) mutants that increase insertion contrary to the PIR were selected. Mutants with strong phenotypes were found only in SPF1 and STE24 (human cell orthologs are ATP13A1 and ZMPSte24) with, at the time, no known relevant functions. Spf1/Atp13A1 is now known to dislocate to the cytosol TM proteins inserted contrary to the PIR, allowing energy-conserving reinsertion. We hypothesize that Spf1 and Ste24 both recognize the short, positively charged ER luminal peptides of TM proteins inserted contrary to the PIR, accepting these peptides into their large membrane-spanning, water-filled cavities through interaction with their many interior surface negative charges. While entry was demonstrated for Spf1, no published evidence directly demonstrates substrate entry to the Ste24 cavity, internal access to its zinc metalloprotease (ZMP) site, or active withdrawal of fragments, which may be essential for function. Spf1 and Ste24 comprise a PIR quality control system that is conserved in all eukaryotes and presumably evolved in prokaryotic progenitors as they gained differentiated membrane functions. About 75% of the PIR is imposed by this quality control system, which joins the UPR, ERAD, and autophagy (ER-phagy) in coordinated, overlapping quality control of ER protein function.
New insights learned from the pulmonary to systemic blood flow ratio to predict the outcome in patients with hypoplastic left heart syndrome in the pre-Glenn stage: a single-center study
Authors: Mini Nathalie , Zartner Peter A. , Schneider Martin B. E.
Published: August 2023

Background

To the best of our knowledge, no study has been made until now to determine whether the ratio between pulmonary and systemic blood flow (Qp/Qs) in the pre-stage II (PS2) or pre-Glenn stage can predict the outcome in patients with hypoplastic left heart syndrome (HLHS) who underwent Norwood (NW) palliation.

Patients and methods

From January 2016 to August 2022, 80 cardiac catheterizations in 69 patients with HLHS in NW palliation stage with modified Blalock–Taussig shunt (MBTS) were retrospectively recruited. The Qp/Qs was measured under stable conditions using the Fick formula. None of the patients were intubated. Patients were divided into two groups: Group 1 included patients who underwent planned cardiac catheterization (n = 56), and Group 2 had unplanned examination (n = 13), in which the indication for cardiac catheterization was desaturation in 11 patients and pulmonary over-circulation in two. The composite primary outcome was defined as accomplishing the planned operations (Glenn and Fontan) with freedom from death and reoperation, referring to palliative therapy or heart transplantation. The secondary outcome was freedom from transcatheter intervention in MBTS or pulmonary arteries.

Results

The median follow-up was 48 months (range 6–72 months). The median value of Qp/Qs in Group 1 was 1.75 (range 1.5–2.2). In Group 2, the 11 patients with desaturation, the median value of Qp/Qs was 1.25 (range 0.9–1.45). The two patients with suspected pulmonary overcalculation showed Qp/Qs of 2.3 and 2.5, respectively; a reduction of the shunt size was required. Approximately 96.4% of patients in Group 1 achieved the primary outcome compared with only 30.7% in Group 2. The need for reintervention was 1.8% in Group 1 compared with 61.3% in Group 2. There is a significant relationship between Qp/Qs and the impaired outcome (death, palliative therapy, or heart transplantation) with a p-value of 0.001, a relative risk factor of 3.1, and a 95% confidence interval of 1.4–7.1. No significant relationship between the Qp/Qs and the size of MBTS (p-value of 0.073) was noted.

Conclusion

The Qp/Qs in PS2 can predict outcomes in patients with HLHS in Norwood stage with MBTS. The Qp/Qs between 1.5 and 2.2 with a median of 1.75 seems to be optimal in the patients in PS2. Qp/Qs of <1.5 is associated with pulmonary stenosis, shunt stenosis, and pulmonary hypertension.
Teacher sentiments about physical appearance and risk of bullying victimization: the mediating role of quality of student–teacher relationships and psychological adjustment
Authors: Longobardi Claudio , Mastrokoukou Sofia , Fabris Matteo A.
Published: August 2023

Introduction

This study investigated the relationship between teachers’ sentiments about physical appearance, student–teacher relationships, psychological adjustment, and the risk of becoming a victim of bullying.

Method

Participants consisted of 995 students (471 females, 47.3%; Mage = 11.3, SDage = 1.49) and 64 teachers (56 females, 87.5%; Mage = 47.59). Students reported their levels of psychological adjustment and their involvement with bullying victimization, while teachers rated relationship quality with their students and reported their sentiments about students’ physical appearance. Teachers’ sentiments about physical appearance were analyzed using the NRC Emotion Lexicon. Correlation and mediation analyses were conducted with Mplus, using a multicategorical antecedent.

Results

Results indicate that teachers’ positive ratings of students’ physical appearance were correlated with close teacher–student relationships, less conflictual relationships, whereas negative ratings were correlated with more conflictual student–teacher relationships and increased bullying victimization risk. Psychological adjustment mediated the relationship, with positive adjustment associated with closer relationships and negative adjustment associated with more conflict.

Discussion

This study suggests the importance of teachers’ sentiments about students’ physical appearance. Positive sentiments promote supportive relationships and reduce the risk of bullying victimization, while negative sentiments erano correlate ad una relazione studente-insegnante netagativa and increased risk of bullying victimization. Promoting positive interactions between teachers and students and addressing appearance biases are critical to creating inclusive educational environments. Further research should focus on understanding and examining the impact of teacher attitudes on student well-being and bullying dynamics.
Creating a high-performing school management team: bringing talent to the table for effective service delivery
Authors: Klinck Kezell , Thutulwa Nancy , Pelser Anna-Marie
Published: August 2023

The primary goal of this article is to help members of School Management Teams (SMT) in developing their abilities, which will lead to successful service delivery in secondary schools. The study used a qualitative research technique with an exploratory research design with a structured interview questionnaire to determine if SMTs had certain competences, knowledge, or attributes that increase their abilities and to provide recommendations for enhanced service delivery. The research enlisted the help ofn= 12 participants from four different secondary schools to get first-hand experience of the phenomena under inquiry. Participants were specifically picked for their expertise, knowledge, and talents. Data were collected from participantsviainterviews, and the data were evaluated using content analysis. Atlas-ti (Version 8.2) was used to evaluate data collected from participants. The researcher used a qualitative research approach, namely a phenomenological strategy based on constructivism. With no data modification, this technique was adopted to understand the viewpoints of the SMT inside the selected schools. According to the research results, SMTs have competences, knowledge, and characteristics that increase their abilities, and strengthening these talents leads to efficient service delivery. Leadership, communication, collaboration, and problem-solving abilities were among the talents assessed. Understanding school legislation and regulations, curriculum creation, and teaching strategies were all part of the expertise. Among the characteristics were flexibility, resilience, inventiveness, and enthusiasm. The research advises that SMTs be provided opportunity to develop their abilities via training and mentoring programs based on the results. Several of the duties that School Management Teams (SMTs) are in charge of include procuring teaching and learning resources, updating physical buildings, coordinating community support for funding, and utilizing communication channels. The provision of inclusive learning support in schools is strongly related to these responsibilities. The study determined a certain set of talents and characteristics needed by SMTs, such as interpersonal skills, managerial skills, emotional intelligence, effective communication, and team-building skills. These qualities are essential for SMTs to carry out their duties and contribute to better service delivery. The future improvement of service delivery focus on three critical areas: strengthening academic performance, advancing social justice education, and raising student achievement. It is recommended that, by addressing these issues, service delivery within the educational system will be considerably improved in the future.
A potential therapeutic drug for osteoporosis: prospect for osteogenic LncRNAs
Authors: Meng Fanjin , Yu Yang , Tian Ye , Deng Meng , Zheng Kaiyuan , Guo Xiaolan , Zeng Beilei , Li Jingjia , Qian Airong , Yin Chong
Published: August 2023

Long non-coding RNAs (LncRNAs) play essential roles in multiple physiological processes including bone formation. Investigators have revealed that LncRNAs regulated bone formation through various signaling pathways and micro RNAs (miRNAs). However, several problems exist in current research studies on osteogenic LncRNAs, including sophisticated techniques, high cost for in vivo experiment, as well as low homology of LncRNAs between animal model and human, which hindered translational medicine research. Moreover, compared with gene editing, LncRNAs would only lead to inhibition of target genes rather than completely knocking them out. As the studies on osteogenic LncRNA gradually proceed, some of these problems have turned osteogenic LncRNA research studies into slump. This review described some new techniques and innovative ideas to address these problems. Although investigations on osteogenic LncRNAs still have obtacles to overcome, LncRNA will work as a promising therapeutic drug for osteoporosis in the near future.
Spatiotemporal variations and risk characteristics of potential non-point source pollution driven by LUCC in the Loess Plateau Region, China
Authors: Lyu Jiqiang , Huang Yuanjia , Nie Qiyang , Lu Chen , Zhang Yueyan , Fu Xianghang , Guo Peng , Luo Pingping
Published: August 2023

With increasing human activities, regional substrate conditions have undergone significant changes. These changes have resulted in temporal and spatial variations of non-point source pollution sources, which has a significant impact on the quality of the regional soil, surface water, and groundwater environments. This study focused on the human-disturbed Loess Plateau region and used an enhanced potential non-point-source pollution index (PNPI) model to explore the dynamic changes of regional potential non-point-source pollution (PNP) and the associated risk due to land use and land cover change (LUCC) over the past 31 years. The Loess Plateau region is mainly composed of cultivated land, grassland and forest, which together account for 93.5% of the watershed area. From 1990 to 2020, extensive soil and water conservation measures were implemented throughout the Loess Plateau region, resulting in a significant reduction in the non-point source pollution risk. Using the quantile classification method, the study area’s PNP risk values were categorized into five distinct levels. The results revealed a polarization phenomenon of PNP risk in the region, with an increase in non-point source pollution risk in the human-influenced areas and a rapid expansion of the very high-risk area. However, the non-point source pollution risk in the upstream water source area of the watershed reduced over the study period. In recent years, the rapid urbanization of the Loess Plateau region has been the primary reason for the rapid expansion of the very high PNP risk area throughout the watershed. This study highlights the significant impact of LUCC on the dynamic changes in PNP risk within the Loess Plateau region, providing crucial insights into future conservation and urban planning policies aimed at enhancing the ecological health and environmental quality of the region.