bluuebunny/crossref_metadata_2025 huggingface dataset:
APLICAÇÃO DAS GEOTECNOLOGIAS NA ANÁLISE AMBIENTAL DO POTENCIAL EROSIVO DO MUNICÍPIO DE BATAGUASSU/MS
Authors: Vieira Paulo Henrique
Published: April 2022

O homem transforma constantemente a paisagem, em escala e tempo variados, de acordo com suas necessidades e interesses. Estas alterações, ocasionalmente, podem promover degradações ambientais, como os processos erosivos. Neste contexto, este trabalho tem como finalidade analisar o potencial erosivo no município de Bataguassu/MS, através da análise dos aspectos físicos (pluviosidade, solos, declividade e geologia) do meio ambiente. O município localiza-se na microrregião de Nova Andradina/MS, na região leste do estado de Mato Grosso do Sul. Para atingir o objetivo proposto o trabalho apoia-se nos seguintes materiais e procedimentos metodológicos: dados referentes aos aspectos físicos de Bataguassu/MS; uso das geotecnologias, destaque para o software de SIG (Sistema de Informação Geográfica) o ArcGIS modelo 10.3; elaboração de mapas temáticos dos aspectos físicos e sua integração para elaboração do mapa de potencial erosivo, seguindo adaptação metodológica do Ross (1994). O mapa de potencial erosivo foi dividido em classes temáticas (muito fraca; fraca; média; forte; muito forte), as quais evidenciam os diferentes níveis de susceptibilidade a erosão do município de Bataguassu/MS. Assim, acredita-se que a identificação dos locais de potencial erosivo pode auxiliar na definição das diretrizes a serem implementadas e nortear o planejamento ambiental do município.
Projetos Político Pedagógicos dos Bacharelados em Gastronomia no Brasil: uma abordagem cartográfica dos cursos ofertados nas universidades públicas federais
Authors: Pinto Soares Cláudia Mesquita , Figueiredo Gustavo Oliveira , Sá Marcia Bastos de
Published: April 2022

O presente artigo faz um recorte da pesquisa de doutorado, ainda em andamento que se interessa pelos jogos das relações entre a formação superior em Gastronomia, notadamente os bacharelados de universidades públicas e a constituição de seu campo teórico acadêmico, buscando explorar, nesse recorte os projetos pedagógicos dos cursos de bacharelado na UFRPE, UFBA, UFC, UFRJ, UFPB, através do conceito de dispositivo e das categorias saber – poder – subjetividade de Michel Foucault e usando a cartografia como método para problematizar os delineamento dos saberes do campo da Gastronomia e a formação superior do Gastrônomo.
Alterícidio por apropriação cultural: O caso do acarajé
Authors: Evangelista Lázaro de Oliveira , Rocha Cristianne Maria Famer
Published: April 2022

O presente artigo tem como o objetivo discutir processos de apropriação cultural que ocorrem no âmbito do Turismo e suas consequências relativas a esta atividade nas dinâmicas sociais das regiões e dos povos. Para tanto, as discussões serão feitas a partir de análises interdisciplinares, considerando as perspectivas dos Estudos Culturais, articuladas ao campo do Turismo e da Gastronomia. O estudo toma como base dados históricos e contemporâneos, referentes ao perfil do viajante no Brasil e em partes do mundo, bem como através de estudos de casos sobre a gourmetização do acarajé, conceitos e perspectivas sobre culturas e humanidade.
Culinária tradicional quilombola: expressões culturais e potencialidades turísticas da Comunidade Cocalinho -Tocantins
Authors: Sudré Stephanni Gabriella Silva , Caldeira Regiane , Siares Tiago Diniz
Published: April 2022

O presente estudo teve como objetivo central conhecer expressões culturais da comunidade quilombola Cocalinho, localizada no estado do Tocantins, conferindo ênfase às produções culinárias e seu potencial para atratividade turística. Foram estabelecidos como objetivos específicos, a) Caracterizar a comunidade a partir de breve histórico; b) identificar recursos culturais da comunidade expressos em dias festivos; c) descrever produções culinárias tradicionais presentes nos dias de festa e d) discutir o papel da culinária tradicional como recurso para valorização cultural, afirmação étnica e atração turística . A pesquisa adotou abordagem qualitativa para geração e análise de dados, sendo realizada em três fases: pesquisa bibliográfica, observação participante e entrevistas por meio remoto. Os resultados indicaram que a culinária tradicional quilombola desenvolve diferentes papéis dentro da comunidade como o sustento físico, marcador identitário, construção de tradições, representa ainda, um dos elementos de maior destaque dentro do leque de atrativos culturais desse território, o que ressalta seu potencial como figura emblemática dessa cultura.
Consumos de peixe em São Borja-RS: Um estudo nos bairros do Passo e Paraboi
Authors: Soares Frederico Cid , Magalhães Anna Luíza Viana , Roque Aline Prestes
Published: April 2022

São Borja é uma cidade missioneira que faz fronteira com a Argentina, a divisão é feita pelo rio Uruguai. O rio é fonte de diversas espécies de peixes que são consumidos por moradores da cidade e de cidades vizinhas. Assim, o trabalho visa comparar o consumo de peixe em São Borja, em diferentes bairros, um à margem do rio (bairro do Passo) e um mais distante (bairro Paraboi). A metodologia utilizada para realizar esse trabalho foi pesquisa bibliográfica e pesquisa de campo, que consistiu em um questionário online para os moradores desses bairros. Verificou-se que dos entrevistados em sua maioria consomem peixes de 1 a 2 vezes no mês. Os resultados obtidos foram satisfatórios e surpreendentes, pois os moradores do bairro afastado do rio (Paraboi) consomem peixe tanto quanto os mais próximos ao rio (Passo), e eles ainda consomem em sua maioria peixes comprados direto com o pescador, enquanto no Passo em sua maioria são comprados nos supermercados.
Os desafios enfrentados pela Agricultura Familiar para sua inserção na Diversificação da Produção de Alimentos
Authors: Schuster Percí Roberto , Deponti Cidonea Machado
Published: April 2022

Este artigo analisou os principais desafios que se colocam aos agricultores familiares do Vale do Rio Pardo/RS, para que estes possam se inserir na atividade da diversificação de culturas, tendo como foco principal a produção de alimentos, como alternativa de superação frente à insustentabilidade da monocultura do tabaco na região. Para tanto, utilizou-se como método de coleta de dados entrevistas semiestruturadas com 19 (dezenove) alunos do terceiro ano do ensino técnico da Escola Família Agrícola de Santa Cruz do Sul - EFASC, filhos de agricultores familiares e/ou produtores de tabaco. Os estudantes e seus familiares são oriundos de 8 (oito) dos distintos municípios da região de estudo. A análise dos dados contou com o método de análise de conteúdo a partir de categorias que serviram de suporte à compreensão e à interpretação dos dados. Concluiu-se que os agricultores da região acostumaram-se ao longo de muitos anos com as relações mercantis que foram acumuladas e estabelecidas pelo Sistema Integrado de Produção do Tabaco (SIPT). Todavia, há de se observar um despertar dos agricultores em relação à problemática do tabaco em detrimento às atividades de diversificação da produção de alimentos. Verifica-se que existe a compreensão e a capacidade de produção para implantação da diversificação. Porém, a presente pesquisa não identificou a diversificação de culturas como geradora de renda nas propriedades rurais, apesar da diversidade produtiva existente, do nível de escolaridade dos mais jovens, da formação técnica bem estruturada na EFASC e da vontade de empreender no setor.
Compreensões sobre ação educativa no campo: as oficinas terapêuticas e a territorialização do cuidado
Authors: Karnopp Erica , Vieira Maria da Graça Lucas
Published: April 2022

O artigo traz algumas compreensões sobre os desafios da ação educativa no campo, através da análise das oficinas terapêuticas e a territorialização do cuidado. O percurso metodológico se deu no cotidiano do serviço, no qual participava-se das reuniões de equipe e acompanhava-se a produção do cuidado dentro e fora do grupo. No processo de educação permanente junto à equipe, foi possível produzir visibilidade a três movimentos: a invisibilidade do território vivo na produção das redes de cuidado; a necessidade do matriciamento como articulador das ações e da atenção básica; e os impasses para a desinstitucionalização da vida. No entanto, apostamos que, no movimento de abrir-se ao mundo vivo do campo, a saúde mental consiga produzir cuidados para além do sofrimento psíquico, se ocupando com a produção de vida das pessoas.
A Diversificação na Agricultura Familiar: Contribuição dos egressos da Escola Família Agrícola de Santa Cruz do Sul (Efasc)
Authors: Doege Fernando , Etges Virginia Elisabeta
Published: April 2022

Este artigo traz algumas reflexões acerca da agricultura familiar na região do Vale do Rio Pardo, que tem na produção de tabaco sua principal atividade. O controle das empresas sobre o processo de cultivo do tabaco limita as possibilidades de diversificação de atividades entre os jovens do meio rural, o que tem levado muitos a migrarem para os centros urbanos. A Escola Família Agrícola de Santa Cruz do Sul - EFASC, criada em 2009, tem como um dos seus propósitos preparar jovens do meio rural da região do Vale do Rio Pardo com formação técnica, voltada à diversificação de atividades na agricultura familiar. Nesta pesquisa buscou-se investigar a contribuição de egressos da EFASC na diversificação de atividades na agricultura familiar na região. Para tanto foram realizadas entrevistas semiestruturadas com egressos das turmas de 2011 e 2012, além de levantamento bibliográfico e de dados em fontes secundárias sobre o tema. Os resultados evidenciaram que a escola, juntamente com o apoio de uma rede de entidades e das famílias dos jovens, prepara os estudantes para decidirem, de forma autônoma, sobre a permanência, ou não, no meio rural. Apontam também dificuldades referentes à disponibilidade de mão de obra, tendo em vista que são famílias com poucos integrantes e, em alguns casos, com problemas de saúde ou aposentados. Questões relacionadas ao tamanho das propriedades, que têm em média de 12 hectares, e o receio de realizar novos investimentos, em razão do grande risco de endividamento, também foram apontados como fatores limitadores para a diversificação. Como conclusão evidenciou-se que os jovens estão preocupados com a produção de alimentos saudáveis para o consumo, com práticas de manejo menos prejudiciais à saúde, dedicando-se à produção orgânica, sem a utilização de agrotóxicos.
Внутреннее управление российских вузов: взгляд практиков в условиях меняющейся среды
Authors: Платонова Дарья , Никифирова Нина
Published: April 2022

В бюллетене представлен анализ внутреннего управления в российских государственных вузах, которые включены в сложную систему правил, ограничений и стимулов. Приводятся ключевые характеристики условий работы российских вузов, включая государственное регулирование, новые проекты по трансформации управления вузами, типичные внутренние структуры принятия решений в вузах. Рассматриваются управленческие подходы российских вузов в следующих трех разрезах: структура принятия решений, стратегии и приоритеты развития, практики «хорошего менеджмента». Эмпирической базой анализа является опрос руководителей вузов и руководителей научных и образовательных подразделений вузов в рамках Мониторинга экономики образования НИУ ВШЭ. Исследование базируется на выделении трех групп вузов – ведущие, средние, отстающие – по данным Мониторинга эффективности деятельности вузов Минобрнауки России.
Дистанционный режим как вызов для школьного образования
Authors: Мерцалова Татьяна , Сенина Наталья
Published: April 2022

В информационном бюллетене представлены результаты опроса родителей и учителей, проведенного в рамках Мониторинга экономики образования в 2020/2021 учебном году. Ключевыми направлениями анализа стали определение готовности в работе в дистанционном режиме и выявление основных трудностей и вызовов, с которыми столкнулись участники образовательного процесса в период массового перехода школ на дистанционный формат обучения весной 2020 г. Особое внимание уделяется вопросу наличия дистанционного опыта у школ и учащихся до пандемии и оценке его возможных положительных эффектов в период кризиса. Массовый переход на дистанционный режим обучения обострил проблему неравенства в образовании. В рамках исследования выявляются группы учащихся и учителей, которые оказались наиболее готовы к столь резкой трансформации учебного процесса, а также те, кто столкнулся с наибольшими трудностями.
The impact of stock market capitalisation, international investment, clean energy on CO2 emissions: New insight from listed domestic companies in Belgium
Authors: Benjamin Ampomah Asiedu , Emmanuel Adu Boahen
Published: April 2022

The paper fundamentally explores the impact of Belgium’s stock market capitalization, international investment, clean energy on CO2 emissions from 1990-to 2018. More pertinently, our study analogizes the diverse impact of Belgium’s stock market capitalization, international investment, clean energy, and environmental quality. Through cointegration analysis, stock market capitalization, international investment, clean energy, and environmental quality have long-run links. Granger causality test indicates that International investment has a unidirectional relationship with environmental quality; clean energy has a bi-directional relationship with environmental quality. Via the static and dynamic regression, we found that stock market development has the most significant impact on carbon dioxide emissions in static and dynamic regression. Renewable energy has a positive impact on the carbon dioxide emissions per static, and dynamic regression and economic growth harm environmental quality in Belgium. The impulse response function results show that the Stock market and international investment positively respond to environmental quality. Our empirical findings provide policies to advocate improving environmental quality in Belgium.
[RETRACTED] Alpha Active Male Enhancement Reviews - Is Alpha Active ME Supplement Scam or Legit Pills? v1
Authors: not provided wogabophin
Published: April 2022

[RETRACTED]

Alpha Active Male Enhancement Reviews
Counting kidneys v1
Authors: J J. Barrero Gabriel , Palmer Abraham , Polesskaya Oksana
Published: April 2022

Dissecting and counting kidneys in rats.
[RETRACTED] Mana FX CBD Gummies Reviews [Shark Tank Alert]: Price & Side Effects v1
Authors: FX CBD Gummies Mana
Published: April 2022

[RETRACTED]

Mana FX CBD Gummies
[RETRACTED] Hindi CBD Gummies Lisa Laflamme - Do This Work? 100% Natural, No Side Effects. v1
Authors: Laflamme CBD Gummies Lisa
Published: April 2022

[RETRACTED]

Lisa Laflamme CBD Gummies
[RETRACTED] Willie Nelson CBD Gummies-GUMMIES TO SUPPORT NATURAL HEALTH! v1
Authors: not provided WillieNelsonCBDGummiesCOST
Published: April 2022

[RETRACTED]

https://www.facebook.com/WillieNelsonCBDGummies.official/ https://www.facebook.com/Willie-Nelson-CBD-Gummies-114228937926909 https://www.facebook.com/Willie-Nelson-CBD-Gummies-102477812238638 https://shark-tank.clubeo.com/news/2022/04/20/willie-nelson-cbd-gummies-reviews-fake-or-trusted https://shark-tank.clubeo.com/news/2022/04/20/willie-nelson-cbd-gummies-reviews-top-ingredients-price-scam-al https://youtu.be/u56w76cNMks
[RETRACTED] Slim Culture Keto *BHB Ketone* Fat Burner Pills Reduce Overweight & Obesity From Body! v1
Authors: Culture Keto Slim
Published: April 2022

[RETRACTED]

Slim Culture Keto Support to loose weight naturally in a easy way it is trending and an effective formula. *Shocking Price* it 100% risk-free & it works quickly must visit website before buy
High coverage and timeliness of vaccination of children under 6 years of age in Risaralda, Colombia v1
Authors: Machado Alba Jorge
Published: April 2022

Introduction. Child vaccination is one of the most cost-effective processes and interventions in public health. Objective. To determine coverage and timeliness of immunization in a sample of children under 6 years of age from a region of Colombia. Methods. Retrospective cohort study that evaluated the vaccination coverage and timeliness verification survey conducted in 2019 to a population of 2457 children under 6 years of age from Risaralda, Colombia. Variables such as age, municipality of residence, record of vaccines included in the national expanded program of immunization (EPI: BCG, hepatitis-B [HBV], diphtheria/pertussis/tetanus [DTP], Haemophilus influenzae [Hib], polio, rotavirus, pneumococcus, influenza, measles/mumps/rubella [MMR], Varicella, hepatitis-A [HAV], yellow fever), date of immunization were considered. Vaccination was defined as timely until 29 days after the day established by the EPI. Results. Survey evaluated children from 14 municipalities, with a mean age of 27.1±21.4 months. Respective coverage and timeliness by age group and vaccine were: newborns: BCG (100% -99.4%), HBV (99.7% -99.7%); 2 months: pentavalent -1 (DPT + Hib + HBV: 91.3%), polio, rotavirus and pneumococcus: 91.3%; 4 months: pentavalent -2 (88.0%), rotavirus, pneumococcus (97.0% -79.4%); 6 months: pentavalent -3 (95.0% -79.4%), polio (95.0% -79.4%), seasonal influenza (85.6% -85.6%), 12 months: MMR (98.0% -94.1%), Varicella (98.0% -94.3%), pneumococcus (98.0% -94.1%), HAV (98.0% -98.9%); 18 months: DPT Booster (91.0%-89.1%), polio (91.0% -89.1%), yellow fever (49.2% -49.2%); 60 months: DPT (95.0%-91.9%) and polio (95.0% -91.9%). Conclusions. Before COVID-19 pandemic, EPI demonstrated high coverage and timeliness in vaccination of children under 5 years of age; however, timeliness for third dose of DTP-Hib-HBV and polio identified opportunities for improvement.
[RETRACTED] Alpha Active Male Enhancement Reviews - Is Alpha Active ME Supplement Scam or Legit Pills? v1
Authors: not provided inellarmst
Published: April 2022

[RETRACTED]

Alpha Active Male Enhancement Reviews
Sedentary habits and physical health of secondary school students in online classes during the pandemic COVID-19
Authors: Ćibo Nejra , Omerović Hana , Žilić Amar , Obradović Zarema , Omerović Đemil , Tanović Edina
Published: April 2022

Introduction: Due to the declaration of a state of emergency in the country due to the pandemic COVID-19, the education system was changed to online teaching. The implementation of distance education has led to an increased sedentary lifestyle, decreased physical activity, and increased use of information technologies. The purpose of this study was to analyze the sedentary habits of female students and their physical health during a period of restricted physical activity with reference to online instruction.Methods: The research was conducted among the first to third grade students of Secondary School Konjic, 45 days after the implementation of online instruction. Students of general secondary school (N = 83), business school (N = 68), and medical school (N = 55) completed the questionnaire after their parents gave their consent.Results: The total number of students surveyed was 206, with students from all three schools studied participating in online classes for up to 4 hours. Medical school students spend more than 3 hours completing schoolwork, while students at the other two schools spend up to 2 hours. Statistically significant differences in non-use of information technology during free time exist among medical students (p = 0.00). Female medical students reported daily symptoms such as headaches, reactions to the visual organ (dry eye, redness, and tearing), and pain in the fist area (twitching, cramps, and tingling). Statistically significant differences in the occurrence of pain in the upper back and chest girdle occurred in students of business school (p = 0.00) and general high school (p = 0.00) compared to medical students.Conclusion: Medical students who use information technology the most reported headaches, pain in the fist area, and frequent reactions to the sense of sight (dry eye, lacrimation, and redness). Assuming inappropriate positions during prolonged use of technology may contribute to poor posture.
Understanding Social Inclusion in Contemporary Society: Challenges, Reflections, Limitations, and Proposals
Authors: Cano-Hila Ana Belén
Published: April 2022

In 2015, the UN approved the 2030 agenda on sustainable development, intending to bridge—and eventually close—the gaps that divide our societies. These 17 sustainable development goals (SDGs) are presented as a master plan that covers the most painful global challenges to a knowledgeable and inclusive society. In this thematic issue we look more incisively into goals no. 1 (no poverty), no. 4 (quality of education and inclusive education), no. 10 (reduced inequalities), and no. 11 (sustainable cities and communities) of the agenda. Social inequalities have drastically intensified after the 2008 financial crisis and the period of austerity that followed, especially among the poorest people and in the most vulnerable communities. Nowadays particularly, with the Covid‐19 pandemic, these gaps seem to be growing. Against this background, this thematic issue aims to capture, make visible, understand, and analyze how social actors are organizing themselves and collaborating amongst each other in order to help attenuate and satisfy dramatic emerging social needs and improve living conditions, especially among the most vulnerable social groups, in uncertain times of crisis. We focus particularly on two main thematic blocks: social inclusion axes on the one hand (formal, non‐formal, and informal education, participation, leisure time, and culture) and vulnerable groups on the other (including children, adolescents, youth, women, the elderly, people with disabilities, and migrants). Contributions to this thematic issue offer interesting conceptual, methodological, and empirical approaches to the study of social inclusion and social inclusive experiences in contemporary societies in uncertain times, particularly in Spain, Portugal, Belgium, and Brazil.
Modern strategies for the treatment of patients with kidney cancer of brain metastases: literature review
Authors: Roshchina K. E. , Bekyashev A. Kh. , Naskhletashvili D. R. , Osinov I. K. , Savateev A. N. , Khalafyan D. A.
Published: April 2022

According to the literature, metastatic brain damage in kidney cancer occurs in 6.5 % of patients. The introduction of new techniques associated with the use of targeted drugs, immune checkpoint inhibitors and innovative radiation therapy techniques can significantly increase patient survival. Effective drug therapy and local control of brain metastases are of paramount importance for predicting overall survival and quality of life for patients. This literature review summarizes the scientific literature data on the use of local and systemic methods of treatment in patients with metastases of kidney cancer to the brain.
Estimation of the prevalence of HPV-positive squamous cell carcinoma of the oropharynx on the example of a separate sample in the Russian Federation
Authors: Pkheshkhova B. G. , Mudunov A. M. , Azizyan R. I. , Pak M. B. , Ishchenko K. B.
Published: April 2022

Introduction. The increasing incidence of oropharyngeal squamous cell carcinoma observed globally in recent decades gave rise to research in this area. In 2005, human papillomavirus was proved to be an etiological factor of oropharyngeal squamous cell carcinoma. Currently, oropharyngeal squamous cell carcinoma associated with human papillomavirus is believed to have some unique characteristics. The analysis of oropharyngeal squamous cell carcinoma epidemiology appears to be highly relevant.

Objective – to assess the incidence and prevalence of oropharyngeal squamous cell carcinoma associated with human papillomavirus in Russia on the example of a certain sample of patients.

Materials and methods. We analyzed medical records of 199 oropharyngeal squamous cell carcinoma patients treated in N. N. Blokhin Russian Cancer Research Center between 2016 and 2021. We analyzed the frequency of tumors associated with human papillomavirus, age, sex, tumor spread and stage depending on р16 status.

Results. More than half of the patients from our cohort (58.3 %) were р16‑positive. The peak incidence was observed in individuals aged 45 to 64 years (more than 60 % of cases). Males were twice as likely to have р16‑positive tumors than females. A total of 60.9 % of patients with р16‑positive tumors had stage I disease, whereas 51.2 % of patients with p16‑negative tumors had stage IV disease.

Conclusion. The results obtained for a sample of Russian patients are comparable with the findings of foreign authors.
Features of microcirculation and metabolism in the skin and soft tissues of the injured area in experimental explosive trauma
Authors: Shperling Igor A. , Rostovtsev Sergey O. , Shulepov Alexander V. , Kourov Anton S. , Bazhenov Michail V.
Published: April 2022

Time, nature, and duration of changes in microcirculation and metabolism, as well as their differences in skin and muscle tissue of the injured area during experimental explosive trauma in rats in different wound process phases, are evaluated. Experimental explosive damage was simulated on 30 Wistar rats. The total condition of rats, their activity, interest in food and water, wound area with characteristic wound healing time calculation, the volume of injured pelvic limb, and changes of microcirculation and metabolism in the skin and skeletal muscles of the paravulnar region were evaluated. The explosive damage has led to a deterioration of microcirculation and metabolism in the skin, and especially, in the muscles of the injured area. Compared to the intact group, the microcirculation deterioration resulted in a decreased constant component of perfusion in the skin and muscles by 57.6% and 40.9% and a decreased vial by 76.9% and 76.5%, respectively (p 0.05), as well as in reducing the fluorescent oxygen intake in the skin and muscles by 25.7% and 51.8% and a complex indicator of effective oxygen exchange by 81.1% and 91.9%, respectively (p 0.05). During the experiment, the microcirculation and metabolism were gradually restored, which is more pronounced in the skin, except for the repeated deterioration of the non-vascular regulation of microcirculation in the muscle (a decreased vial by 29.3% of the norm, p 0.05). Changes in the main indicators of microcirculation and metabolism indicate normal skin defect healing and unsatisfactory muscle defect repair (decreased volume of the injured limb (68% of the norm, p 0.05)), accompanied by the recurrence of extravascular disorders in the muscle. Developing new and improved existing methods of delivering biologically active drugs and drugs to the area of muscular damage in the early days after the injury, which strengthen the local blood flow and create conditions for damaged muscle regeneration, reduce the wound healing time without forming pathological scars.
Inflammatory response and its correction in forming a host response to exposure to adverse environmental factors
Authors: Ponomarev Denis B. , Stepanov Alexander V. , Ivchenko Evgeny V. , Seleznev Alexey B. , Apchel Vasiliy Y.
Published: April 2022

This study systematically review knowledge about the mechanisms of formation of an inflammatory reaction under the influence of biological, physical, and chemical factors, their similarities and differences, and possible methods of pharmacological correction of pathological conditions associated with excessive activation. The effect of adverse environmental factors, such as biological, physical, and chemical factors, causes a systemic response, which is aimed at maintaining homeostasis and is caused, among other things, by a coordinated reaction of the immune system. Phlogogenic agents result in the activation and regulation of the inflammatory response, which is formed by cellular and humoral components of innate immunity. The activation of innate immunity is characterized by a rapid host response, which diminishes following the elimination of foreign invaders, endogenous killer cells, and neogenesis. Depending on the nature of the active factors (biopathogens, allergens, toxins, ionizing radiation, etc.), the mechanisms of immune response arousal have unique features mainly originating from the differences in the recognition of specific molecular patterns and danger signals by different receptors. However, inflammatory mediators and inflammatory response patterns at the systemic level are largely similar even under widely different triggers. Inflammation, having evolved as an adaptive reaction directed at the immune response, can lead to the development of chronic inflammation and autoimmune diseases due to a mismatch in mechanisms of its control. A failure in the regulation of the inflammatory process is the excessive activation of the immune system, which leads to the cytokine release syndrome (hypercytokinemia, or cytokine storm) and can cause self-damage (destruction) of tissues, multiple-organ failure, sepsis, and even death. Modern advances in the study of the pathogenetic bases of the inflammatory response are suggested, such as pharmacological correction using pattern recognition receptor antagonists, pro-inflammatory cytokine inhibitors, or blocking of key control genes or signaling pathways.
Historical and medical-pharmaceutical aspects of the creation of a pharmacopeia
Authors: Miroshnichenko Yuri V. , Perfiliev Alexander B. , Kostenko Natalya L. , Enikeeva Rimma A.
Published: April 2022

The article presents a historical analysis of the works of ancient authors related to the standardization and use of medicinal products underlying their prescriptions, as well as the Antidotaria, Dispensatoria, Ricettaria, and other publications that became the basis of modern pharmacopoeia. Based on the results of the analysis of literary sources on the history of medicine and pharmacy, issues of the standardization and regulation of prescription of medicinal products have always been given special importance in various societies and cultures. The chronology of the collections of prescriptions of medicinal products and then the establishment of a pharmacopoeia indicates the great need for pharmaceutical information for healthcare, determines the stages of development of pharmaceutical science, production, pharmaceutical and medical practice, and standardization and state regulation of medical and pharmaceutical activities. Particular attention is paid to the history of the creation of the first editions of the Russian pharmacopoeia. From physicians, herbalists, and greenery workers, practical information on the treatment of diseases in Russia was then translated, added to the official editions of the pharmacopoeia, and adopted at the state level. The significant contribution of domestic scientists is reflected, thanks to which the domestic pharmacopoeia not only did not yield to foreign counterparts but in some cases even surpassed them, contributing to the development of the countrys healthcare. The role of the staff of the Imperial MedicalSurgical (Military Medical) Academy, who actively participated in the development of various editions of the national state pharmacopoeia during the XIXXXI centuries, is emphasized.
The prospects of probiotics and prebiotics in the diet of military personnel in extreme conditions
Authors: Subbotina Tatyana I. , Smirnova Galina A. , Kravchenko Elena V. , Andriyanov Anton I. , Smetanin Alexander L.
Published: April 2022

The prospects of using probiotics and prebiotics in the diets of military personnel in extreme conditions have been studied. Domestic and foreign publications were used as the research material using the database of the United States (US) National Library of Medicine, Medline, and PubMed search engine. The nutrition of military personnel in extreme conditions should aim to improve diets by including functional nutrition products in their composition, such as probiotics and prebiotics. Herein, presented the modern concept of targeted probiotics, as well as the advantages of metabolic probiotics (metabiotics). The study results of the combined prebiotic in military personnel under environmental and professional stress, as well as in crew members in a closed hermetic object, are presented. The positive effect of probiotics and prebiotics in persons of dangerous professions against the background of excessive physical exertion or having a reduced nutritional status was revealed. The study of the metabiotic Bactistatin confirmed its effectiveness as a means of nutritional and metabolic rehabilitation of military personnel with inadequate body weight. The inclusion in the diets of products that normalize the microbiom is recognized as one of the directions for improving the nutrition of the North Atlantic Treaty Organization military personnel. Probiotics and prebiotics in the US Army diets contributed to intestinal infection prevention and immune system strengthening, thereby increasing endurance, physical, and cognitive performance during combat stress, and thus improving adaptation in extreme conditions. Domestic and foreign experience in the use of probiotics and prebiotics in diets has shown the prospects of their use as a means to improve the health and the military-professional of military personnel in extreme conditions of life.
To physiology of splanchnic nerves
Authors: Polumordvinov Dmitry V.
Published: April 2022

There are rather meager indications in the literature about the relation of the splanchnic nerves to the urinary bladder. Zeissl recognizes the existence of motor fibers in these nerves, since he was able to cause bladder contractions by stimulating the large abdominal nerves. Which way these fibers reach the bladder is left unclear by the author; he could only make sure that after the two-sided cutting of n. n. hypogastrici and erigentes, that is, after cutting all the motor nerves of the bladder, irritation of the splanchnic nerves ceased to have an effect.
Editorial board of the journal "Neurological Bulletin"
Authors: Khasanov Mansur K.
Published: April 2022

The Academy of Sciences of Tatarstan reacted with great attention and hope to the resumption of the publication of the journal Neurological Bulletin. We sincerely welcome its revival!

The Kazan Medical School of Neurologists and Psychiatrists is remarkable for its achievements. The scientific merits of scientists in this field of medicine, their contribution to the development of science and practice are generally recognized. The rich traditions laid down within the walls of the university by the founder of experimental psychology in Russia, V.M. Bekhterev, whose work determined the further development of Russian neurology, the studies of his students and followers, give confidence that the pages of the journal will once again serve to expand and raise to a higher level. level of fundamental research.
Radicular insult
Authors: Popelyansky Y. Y. , Ibatullin М. M.
Published: April 2022

The analysis of 6 observations with the clinical picture of a sudden stopping of mono- and biradicular function permits to stand out the form of radicular insult. It should not be mixed with famous description of ischemic neuritides which essentially present the clinical picture of the extremity tissue ischemia rather than the nerve trunk. The basic features of radicular insult are as follows: the suddenness and manifestation of the motor disturbance in myotoma, disturbance of sensation or paresthesia in dermatoma, euphylline- dependence, primary susceptibility of the root L to the pathologic process. The localization is in the compression zone or from a distance.
Results of the study of epilepsy problem from the viewpoint of systematic approach
Authors: Voloshin P. V. , Mertsalov V. S. , Voloshina N. P.
Published: April 2022

The predisposition to spastic paroxysms occurs as a result of the functional degeneration of focal changes in brain into epileptic process. The metabolic basis of epileptogenesis involves dyscircular hypoxia of the brain. The formation of the epileptic system is associated with the disorder of night sleep structure including the qualitative distribution of cycles. Epilepsy is considered as the increasing pathologic state rather than residual manifestations of one or other brain pathology.
Clinical peculiarities and some neurophysiologic aspects of the spastic syndrome in children aged one year
Authors: Shanko G. G. , Ulezko E. A.
Published: April 2022

The results of clinical and electrophysiologic examination of 116 children aged one year with spastic syndrome are presented. Neurosonographic examination shows the organic changes in brain tissue which manifest themselves as edema and periventricular infiltration in newborns and as ventriculomegalia of different manifestations in infants. The dopplerograms show the descrease of blood flow rate and change of resistance index. The sings of the decrease of the threshold of spastic readiness prevail in children in the second half year of life.
Clinical picture of the prodromal period of traumatic epilepsy
Authors: Lekomtsev V. T.
Published: April 2022

The clinicopsychologic examination of 310 patients suffering from traumatic epilepsy is performed. The basic clinical manifestation of the prodromal period of traumatic epilepsy is the combination of cerebrasthenic symptomatology with parasomnipathic disorders of paroxysmal nature.
Recovery criteria of patients with epilepsy
Authors: Gromov S. A.
Published: April 2022

Using the clinical data of long-standing observations of patients with epilepsy, the problems of their possible recovery are considered. As the objectivating criteria, the data of clinical, electroencephalogram, psychologic, and biochemical investigations are given with their characteristics suggesting the regression of epilepsy. The conclusions regarding the possibility of practical recovery of the patients of this type are made.
Trigger phenomena of peripheric localization
Authors: Ivanichev G. A. , Levit K. , Karlov V. А.
Published: April 2022

The distinction of trigger phenomena of extraceptive, proprioceptive and visceral localization is justified neurophysiologically. The basis for classification is the concept of generative, determinant systems of peripheric genesis. The basis of trigger phenomena is the pathologic stability, pathologic recurrence, pathologic subjection of neuronic centers in stimulating process. The clinical correlators of these processes are characterized by local and reflected pain, stability of painful phenomena, frequent replases following the treatment, local indurations of various sizes, changes of electrophysiologic characteristics, local vegetative disorders.
Clinicopsychologic examination of peculiarities of adult patients with so-called infantile cerebral paralysis
Authors: Bogdanov E. I. , Ivanova V. A. , Kalmykov Y. А. , Muchametzyanov R. Z. , Gallimulina Z. А.
Published: April 2022

The clinical and experimental-and-psychologic examination of 72 patients with infantile cerebral paralysis aged 16 to 35 years is performed. The adapted variant of MMPI, Kettels 16-factor questionnaire and so on are used for the examination of patients personality. As many as 56 patients are treated by means of Rodjers group psychotherapy course. The tendency to progressive smoothing over psychogenetic pathologic development of the personality of a deficient type in adult patients with infantile cerebral paralysis is revealed. The individual psychologic perculiarities of patients with infantile cerebral paralysis in late residual period as well as their dependence on the overwhelming neurologic syndrome and the degree of motor function disorders are described. The group psychotherapy results in the increase of activity, sociability, self-reliance and decrease of emotional instability.
Combined assessment of the immune system state in women suffering from neurotic disorders
Authors: Polozhy B. S. , Vasilyeva O. A. , Ivanova S. А.
Published: April 2022

The combined clinicoimmunologic examination of 102 patients with neurosis and 58 psychially healthy women working at large industrial works is performed. The definite changes in the immune status are established to correlate with not one or other nosologic form but dynamic stage of the disease development. The combined analysis of clinical, immunologic, and hormonal characteristics permits to stand out the predictor with respect to favourable and unfavourable course of neuroses.
Evaluación de la susceptibilidad in vitro a esparteína, en cuatro cepas de Mycobacterium tuberculosis
Authors: Hidalgo Manuel , Asmat Marrufo Percy , Lezama Asencio Pedro , Ramos Cynthia , Chimoy Tuñoque Carlos Alfonso , Zolla Gastón
Published: April 2022

La esparteína es un alcaloide con actividad bacteriostática sobre el género Mycobacterium. El objetivo de este trabajo fue evaluar la acción antimicrobiana de la esparteína en el crecimiento de cuatro cepas ATCC de Mycobacterium tuberculosis (susceptible, resistente a isoniazida, resistente a rifampicina y multidrogorresistente) in vitro. La evaluación de la actividad bactericida del sulfato de esparteína se realizó a través de una adaptación del método de ensayo de cultivo y susceptibilidad a medicamentos antituberculosos mediante observación microscópica (MODS, por sus siglas en inglés), según el protocolo descrito en el manual técnico elaborado por el Instituto Nacional de Salud. Los resultados demuestran que a concentraciones de 25; 50 y 100 mM de sulfato de esparteína, no se desarrollan unidades formadoras de colonia en las cuatro cepas evaluadas de Mycobacterium tuberculosis. Los resultados demuestran el potencial efecto antimicrobiano in vitro de la esparteína en la tuberculosis multidrogorresistente.
Diabetes mellitus tipo 2 y características del sueño: un estudio poblacional en Tumbes, Perú
Authors: Ruiz-Burneo Lucía , Merino-Rivera Jimy A. , Bernabé-Ortiz Antonio
Published: April 2022

Objetivo. Determinar si existe asociación entre la presencia de diabetes mellitus tipo 2 (DM2) y la duración, dificultad para dormir, y calidad de sueño, en sujetos de 30 a 69 años en Tumbes. Materiales y métodos. Estudio transversal analítico. Las variables dependientes fueron dificultad para dormir (a veces/casi nunca y frecuentemente), duración del sueño (normal, corto y prolongado) y calidad del sueño (buena y mala). La variable independiente fue la presencia de DM2 evaluada usando la prueba de tolerancia oral a la glucosa (no DM2, con DM2 y sin diagnóstico previo, y con DM2 y diagnóstico previo). Se usó modelos de regresión de Poisson para reportar razones de prevalencia (RP) e intervalos de confianza al 95% (IC 95%). Resultados. Se analizaron 1604 individuos, con una edad media de 48,2 años; 50,3% fueron mujeres; 71 (4,4%) tenían DM2 sin diagnóstico previo y 105 (6,5%) tenían DM2 con diagnóstico previo. Según las características del sueño, 12,0% presentó sueño corto y 8,2% presentó sueño prolongado; 3,7% reportó dificultad para dormir, y 19,5% tuvo mala calidad de sueño. En el modelo multivariable, tener DM2 con diagnóstico previo estuvo asociado con dificultad para dormir (RP = 2,20; IC 95%: 1,13–4,27) y mala calidad de sueño (RP = 1,40; IC 95%: 1,05–1,92) comparado con aquellos sin DM2. Conclusiones. Los individuos con DM2 que tenían diagnóstico previo tuvieron mayor probabilidad de presentar dificultad para dormir y mala calidad de sueño. Nuestros resultados sugieren la necesidad de evaluar en forma periódica las características del sueño en pacientes con DM2.
COVID-19 y la emergencia que sigue vigente
Authors: Solari Lely
Published: April 2022

-
ß-lactamasas de espectro extendido y factores de virulencia en Escherichia coli uropatógenas en asilos de ancianos en Lima, Perú
Authors: Gonzales-Rodriguez Arturo Octavio , Infante Varilla Stefany Fiorella , Reyes-Farias Carlos Ignacio , Ladines Fajardo Cesar Enrique , Gonzales Escalante Edgar
Published: April 2022

Los asilos de ancianos son instituciones con una alta prevalencia de infecciones del tracto urinario ocasionado por Escherichia coli productoras de ß-lactamasas de espectro extendido (BLEE), con diversos factores de virulencia. El objetivo del estudio fue determinar la frecuencia del gen blaCTX-M y de ocho genes de virulencia en 35 E. coli uropatógenas productoras de BLEE provenientes de seis asilos en Perú, durante el 2018. El 57,1% (20/35) de las E. coli fueron portadores del gen blaCTX-M. Además, se obtuvo una frecuencia del 46% (15/35) y 37% (13/35) de hly-alfa y cnf-1, respectivamente; elevada presencia de los genes iucC (63%, 22/35), aer (94%, 33/35) y chuA (94%, 33/34) y una frecuencia del 46% (16/35) y del 91% (32/34) de los genes pap GII y nanA, respectivamente. Existe predominancia en la distribución del gen blaCTX-M, además de una alta frecuencia de exotoxinas que le confieren una ventaja competitiva para diseminarse hacia el torrente sanguíneo.
Satisfacción y percepciones sobre aspectos de la ciudad que afectan la salud, por nivel socioeconómico, 2010-2019, en Lima Metropolitana
Authors: Cavero Victoria , Hernández-Vásquez Akram , Miranda J. Jaime , Alata Patricia , Alegre Mariana , Diez-Canseco Francisco
Published: April 2022

Se buscó caracterizar la satisfacción y percepciones de los residentes de Lima Metropolitana sobre distintos aspectos de la ciudad que pueden afectar su calidad de vida y salud, identificando diferencias por nivel socioeconómico (NSE) y cambios en el tiempo. Se realizó un análisis secundario de la Encuesta «Lima Cómo Vamos» entre 2010 y 2019, reportando los resultados mediante porcentajes, con diferencias entre NSE para cada año y entre años. En 2019 la satisfacción y percepciones eran mayoritariamente desfavorables, y han disminuido hasta en 30 puntos porcentuales con el tiempo. Las personas de NSE más bajos tenían valoraciones más desfavorables y con mayores reducciones en el tiempo. Esta insatisfacción y percepciones desfavorables revelan deficiencias en servicios públicos y condiciones urbanas que podrían afectar negativamente la calidad de vida y salud, haciendo necesarias políticas que reduzcan las brechas socioeconómicas y mejoren la salud de los ciudadanos de Lima Metropolitana.
Study of GHG emissions in Brazil from 1990 to 2030 using system dynamics for simulation
Authors: Gallegos Raphael
Published: April 2022

This work studied five sectors which are responsible for GHG emissions in Brazil, namely: Agriculture, Energy, Land-use Change, Industrial Processes, and Waste. In addition to emissions, the Brazilian National Energy Balance was studied to understand the relationship between the energy matrix and GHG emissions. This entire study was developed using the System Dynamics methodology and, at the end, two scenarios were proposed. In the first scenario, it is possible to observe how GHG emissions are distributed in Brazil, while in the second scenario, it is possible to observe a reduction of about 48.9% of emissions in the country, related to the reduction of Land-use Change and Forestry together with the Energy Sector.
TÜRKİYE’DE İHRACAT ÇEŞİTLİLİĞİ VE EKONOMİK BÜYÜME İLİŞKİSİ: ARDL YAKLAŞIMI
Authors: ÇELİK Hüseyin
Published: April 2022

Küreselleşmenin artmasıyla birçok alanda uluslararası etkileşim artmaktadır. Bu etkileşimin gerçekleştiği alanlardan biri de ülkelerin talep ettikleri mal ve hizmetlerdir. Bu durum karşısında uluslararası ticarette ihracat rekabet gücüne sahip olan ülkeler daha kazançlı çıkmaktadır. Dolayısıyla dış talebe uygun ürünler üretmek ve bu ürünleri uluslararası pazarlara sunmak ülkelere rekabet avantajı sağlamaktadır. Bu noktadan hareketle, çalışmada Türkiye ekonomisi için teknoloji yoğunluk düzeyinde ihracat çeşitliliğinin ekonomik büyüme üzerindeki etkisini araştırılmaktadır. Çalışmanın diğer çalışmalardan farkı ihracat verilerinin teknolojik yoğunluğu bakımından gruplar halinde ele almasıdır. Çalışma 1989-2020 dönemini kapsamaktadır. ARDL sınır yaklaşımı testinden faydalanılmıştır. Ampirik uygulamalar neticesinde Türkiye’de ihracat ve ekonomik büyüme arasında uzun dönemli bir ilişki olduğu görülmüştür. Emek yoğun mallar ekonomik büyümeyi pozitif etkilediği ancak sermaye ve teknoloji yoğun malların negatif etkilediği görülmüştür. Hammadde yoğun malların ihracatı ve ekonomik büyüme arasında anlamlı bir ilişki elde edilememiştir.