bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of draping simulations by means of 3D laser scans and robot supported fiber angle scans
Authors: Osterberger Joachim , Maier Franz , Keller Sophia , Hinterhölzl Roland Markus
Published: July 2023

In order to demonstrate the accuracy of macroscopic finite element draping simulations it is necessary to compare the results with experiments. In this work, a compact overview of evaluation methods for draping simulations based on experiments, in the recent literature, is provided. Then, a method using state of the art 3D laser scans (RS6, Hexagon) and robot supported fiber angle scans (FScan, Profactor) is described. The presented comparison of draping results with the tool geometry in 3D allows for an evaluation of wrinkles and bridging areas. For the evaluation of the edge contour, the commonly used method of projecting the edge contour on a 2D plane is extended to a comparison in 3D space. To determine fiber orientations and compare them with the predictions from simulations, a robot supported fiber angle sensor and a script-based mapping and comparison algorithm are used. The results are further analyzed statistically, to derive comparative figures to other results found in the literature. The location and dimensions of macroscopic manufacturing effects such as fiber bridging and wrinkles could be predicted accurately. The final component contour could be on average predicted within 5.2 mm. The fiber orientation could be predicted with a deviation of less than 2° for approx. 65% and within 6° for 95% of the part surface for UD laminas. Cross-ply laminas showed larger deviations, only 40% of the part surface was within 2° and 80% within 6°, compared to the experiment. Overall, the results for the presented methods show good agreement between multi-ply draping experiments and macroscopic simulations conducted with the Abaqus Fabric material model.
The prognostic value of 19S ATPase proteasome subunits in acute myeloid leukemia and other forms of cancer
Authors: Tychhon Boranai , Allen Jesse C. , Gonzalez Mayra A. , Olivas Idaly M. , Solecki Jonathan P. , Keivan Mehrshad , Velazquez Vanessa V. , McCall Emily B. , Tapia Desiree N. , Rubio Andres J. , Jordan Connor , Elliott David , Eiring Anna M.
Published: July 2023

Introduction

The ubiquitin-proteasome system (UPS) is an intracellular organelle responsible for targeted protein degradation, which represents a standard therapeutic target for many different human malignancies. Bortezomib, a reversible inhibitor of chymotrypsin-like proteasome activity, was first approved by the FDA in 2003 to treat multiple myeloma and is now used to treat a number of different cancers, including relapsed mantle cell lymphoma, diffuse large B-cell lymphoma, colorectal cancer, and thyroid carcinoma. Despite the success, bortezomib and other proteasome inhibitors are subject to severe side effects, and ultimately, drug resistance. We recently reported an oncogenic role for non-ATPase members of the 19S proteasome in chronic myeloid leukemia (CML), acute myeloid leukemia (AML), and several different solid tumors. In the present study, we hypothesized that ATPase members of the 19S proteasome would also serve as biomarkers and putative therapeutic targets in AML and multiple other cancers.

Methods

We used data from The Cancer Genome Atlas (TCGA) and the Clinical Proteomic Tumor Analysis Consortium (CPTAC) available at UALCAN and/or GEPIA2 to assess the expression and prognostic value of proteasome 26S subunit, ATPases 1-6 (PSMC1-6) of the 19S proteasome in cancer. UALCAN was also used to associate PSMC1-6 mRNA expression with distinct clinicopathological features. Finally, cBioPortal was employed to assess genomic alterations of PSMC genes across different cancer types.

Results

The mRNA and protein expression of PSMC1-6 of the 19S proteasome were elevated in several cancers compared with normal controls, which often correlated with worse overall survival. In contrast, AML patients demonstrated reduced expression of these proteasome subunits compared with normal mononuclear cells. However, AML patients with high expression of PSMC2-5 had worse outcomes.

Discussion

Altogether, our data suggest that components of the 19S proteasome could serve as prognostic biomarkers and novel therapeutic targets in AML and several other human malignancies.
The potential of fungi in the bioremediation of pharmaceutically active compounds: a comprehensive review
Authors: Amobonye Ayodeji , Aruwa Christiana E. , Aransiola Sesan , Omame John , Alabi Toyin D. , Lalung Japareng
Published: July 2023

The ability of fungal species to produce a wide range of enzymes and metabolites, which act synergistically, makes them valuable tools in bioremediation, especially in the removal of pharmaceutically active compounds (PhACs) from contaminated environments. PhACs are compounds that have been specifically designed to treat or alter animal physiological conditions and they include antibiotics, analgesics, hormones, and steroids. Their detrimental effects on all life forms have become a source of public outcry due their persistent nature and their uncontrolled discharge into various wastewater effluents, hospital effluents, and surface waters. Studies have however shown that fungi have the necessary metabolic machinery to degrade PhACs in complex environments, such as soil and water, in addition they can be utilized in bioreactor systems to remove PhACs. In this regard, this review highlights fungal species with immense potential in the biodegradation of PhACs, their enzymatic arsenal as well as the probable mechanism of biodegradation. The challenges encumbering the real-time application of this promising bioremediative approach are also highlighted, as well as the areas of improvement and future perspective. In all, this paper points researchers to the fact that fungal bioremediation is a promising strategy for addressing the growing issue of pharmaceutical contamination in the environment and can help to mitigate the negative impacts on ecosystems and human health.
Exploring the alteration of gut microbiota and brain function in gender-specific Parkinson’s disease based on metagenomic sequencing
Authors: Zhang Minna , Zhai Zhiyuan , Yang Bo , He Le , Wang Jingyi , Dai Weijie , Xue Liujun , Yang Xiaozhong , Feng Yun , Wang Honggang
Published: July 2023

Background

The role of the microbiota-gut-brain axis in Parkinson’s disease (PD) has received increasing attention. Although gender differences are known to an essential role in the epidemiology and clinical course of PD, there are no studies on the sex specificity of the microbiota-gut-brain axis in the development and progression of PD.

Methods

Fresh fecal samples from 24 PD patients (13 males, 11 females) were collected for metagenomic sequencing. The composition and function of the gut microbiota were analyzed by resting-state functional magnetic resonance imaging (fMRI). Gender-dependent differences in brain ALFF values and their correlation with microbiota were further analyzed.

Results

The relative abundance of Propionivibrio, Thermosediminibacter, and Flavobacteriaceae_noname was increased in male PD patients. LEfse analysis showed that Verrucomicrobial, Akkermansiaceae, and Akkermansia were dominant in the males. In female patients, the relative abundance of Propionicicella was decreased and Escherichia, Escherichia_coli, and Lachnospiraceae were predominant. The expression of the sesquiterpenoid and triterpenoid biosynthesis pathways was increased in male PD patients and was statistically different from females. Compared to the Male PD patients, female patients showed decreased ALFF values in the left inferior parietal regions, and the relative abundance of Propionivibrio was positively correlated with the regional ALFF values.

Conclusion

Our study provides novel clinical evidence of the gender-specific relationship between gut microbiota alterations and brain function in PD patients, highlighting the critical role of the microbiota-gut-brain axis in gender differences in PD.
Synapse-specific diversity of distinct postsynaptic GluN2 subtypes defines transmission strength in spinal lamina I
Authors: Pitcher Graham M. , Garzia Livia , Morrissy A. Sorana , Taylor Michael D. , Salter Michael W.
Published: July 2023

The unitary postsynaptic response to presynaptic quantal glutamate release is the fundamental basis of excitatory information transfer between neurons. The view, however, of individual glutamatergic synaptic connections in a population as homogenous, fixed-strength units of neural communication is becoming increasingly scrutinized. Here, we used minimal stimulation of individual glutamatergic afferent axons to evoke single synapse resolution postsynaptic responses from central sensory lamina I neurons in an ex vivo adult rat spinal slice preparation. We detected unitary events exhibiting a NMDA receptor component with distinct kinetic properties across synapses conferred by specific GluN2 subunit composition, indicative of GluN2 subtype-based postsynaptic heterogeneity. GluN2A, 2A and 2B, or 2B and 2D synaptic predominance functioned on distinct lamina I neuron types to narrowly, intermediately, or widely tune, respectively, the duration of evoked unitary depolarization events from resting membrane potential, which enabled individual synapses to grade differentially depolarizing steps during temporally patterned afferent input. Our results lead to a model wherein a core locus of proteomic complexity prevails at this central glutamatergic sensory synapse that involves distinct GluN2 subtype configurations. These findings have major implications for subthreshold integrative capacity and transmission strength in spinal lamina I and other CNS regions.
Production, identification, in silico analysis, and cytoprotection on H2O2-induced HUVECs of novel angiotensin-I-converting enzyme inhibitory peptides from Skipjack tuna roes
Authors: Zhu Wang-Yu , Wang Yu-Mei , Ge Ming-Xue , Wu Hua-Wei , Zheng Shuo-Lei , Zheng Huai-Yu , Wang Bin
Published: July 2023

Background

Exceeding 50% tuna catches are regarded as byproducts in the production of cans. Given the high amount of tuna byproducts and their environmental effects induced by disposal and elimination, the valorization of nutritional ingredients from these by-products receives increasing attention.

Objective

This study was to identify the angiotensin-I-converting enzyme (ACE) inhibitory (ACEi) peptides from roe hydrolysate of Skipjack tuna (Katsuwonus pelamis) and evaluate their protection functions on H2O2-induced human umbilical vein endothelial cells (HUVECs).

Methods

Protein hydrolysate of tuna roes with high ACEi activity was prepared using flavourzyme, and ACEi peptides were isolated from the roe hydrolysate using ultrafiltration and chromatography methods and identified by ESI/MS and Procise Protein/Peptide Sequencer for the N-terminal amino acid sequence. The activity and mechanism of action of isolated ACEi peptides were investigated through molecular docking and cellular experiments.

Results

Four ACEi peptides were identified as WGESF (TRP3), IKSW (TRP6), YSHM (TRP9), and WSPGF (TRP12), respectively. The affinity of WGESF (TRP3), IKSW (TRP6), YSHM (TRP9), and WSPGF (TRP12) with ACE was −8.590, −9.703, −9.325, and −8.036 kcal/mol, respectively. The molecular docking experiment elucidated that the significant ACEi ability of WGESF (TRP3), IKSW (TRP6), YSHM (TRP9), and WSPGF (TRP12) was mostly owed to their tight bond with ACE’s active sites/pockets via hydrophobic interaction, electrostatic force and hydrogen bonding. Additionally, WGESF (TRP3), IKSW (TRP6), YSHM (TRP9), and WSPGF (TRP12) could dramatically elevate the Nitric Oxide (NO) production and bring down endothelin-1 (ET-1) secretion in HUVECs, but also abolish the opposite impact of norepinephrine (0.5 μM) on the production of NO and ET-1. Moreover, WGESF (TRP3), IKSW (TRP6), YSHM (TRP9), and WSPGF (TRP12) could lower the oxidative damage and apoptosis rate of H2O2-induced HUVECs, and the mechanism indicated that they could increase the content of NO and activity of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) to decrease the generation of reactive oxygen species (ROS) and malondialdehyde (MDA).

Conclusion

WGESF (TRP3), IKSW (TRP6), YSHM (TRP9), and WSPGF (TRP12) are beneficial ingredients for healthy products ameliorating hypertension and cardiovascular diseases.
Comparing the cognitive functioning of middle-aged and older foreign-origin population in Estonia to host and origin populations
Authors: Abuladze Liili , Sakkeus Luule , Selezneva Elena , Sinyavskaya Oksana
Published: July 2023

Background

In migration and health research, the healthy migrant effect has been a common finding, but it usually pertains to specific contexts only. Existing findings are inconsistent and inconclusive regarding the cognitive functioning of the (aging) foreign-origin population relative to the populations of their host and sending countries. Moreover, this comparison is an understudied design setting.

Objective

We analyze the outcomes and associations of cognitive functioning outcomes of the non-institutionalized middle-aged and older population, comparing the Russian-origin population in Estonia with Estonians in Estonia and Russians in Russia in a cross-sectional design. We aim to estimate the (long-term) effects of migration on cognitive functioning in later life, contextualizing the findings in previous research on the healthy migrant effect.

Data and methods

We use data from face-to-face interviews conducted within the SHARE Estonia (2010–2011) and SAGE Russia (2007–2010) surveys. Respondents aged 50+ living in urban areas were grouped by self-identified ethnicity, including 2,365 Estonians, 1,373 Russians in Estonia, and 2,339 Russians in Russia (total N = 6,077). Cognitive functioning was measured using a 25-percentile cut-off threshold for the results of two cognition outcomes - immediate recall and verbal fluency - and the odds of impairment were estimated using binary logistic regression.

Results

Russian men and women living in Estonia have significantly higher odds of impairment in immediate recall than Estonian men and women, though they do not differ from Russians in Russia in the final adjusted models. The differences between all groups are non-significant if age at migration is considered. There are no significant differences between the groups in verbal fluency.

Conclusion

Contrary to the commonly found healthy migrant effect, the middle-aged and older foreign-origin population in Estonia fares initially worse than the native population in the immediate recall outcome, but does not differ from their sending country population, possibly due to Russia’s higher mortality rate and therefore the selective survival of healthier people. Different results depending on the cognitive functioning outcome suggest that migration may affect temporary memory more than crystallized knowledge. However, there are no differences between the groups if defined based on age at migration, which suggests that the age profile differences explain most of the groups’ differences in cognitive functioning.
Nature and Regularities of the Orthorhombic α″-Phase Formation in Binary Titanium Alloys
Authors: Dobromyslov Arkadiy V.
Published: July 2023

A systematic study of the phase composition of quenched binary titanium alloys with d-metals of groups 5–11 from periods four to six was carried out using the methods of X-ray diffraction analysis. It was found that the formation of the orthorhombic α″-phase depends on the position of the alloying metal in the periodic table. The formation of the α″-phase occurs only in the systems Ti-V, Ti-Nb, Ti-Mo, Ti-Ru, Ti-Ta, Ti-W, Ti-Re, Ti-Os and Ti-Ir, and in other systems, it does not occur. It was found that the critical parameter for the formation of the α″-phase is the difference in the size of titanium atoms and those of the alloying metal {(rTi − rMe)/rTi 100%}. The formation of the α″-phase occurs only in systems where this value is lower than 9 at.%.
Book Review: Routledge Handbook of Animal Welfare; Knight et al., Eds.; Routledge: Abingdon, UK; New York, NY, USA, 2023; ISBN: 978-1-032-02206-2 (hbk), 978-1-032-32575-0 (pbk), 978-1-003-18235-1 (ebk)
Authors: Fraser David
Published: July 2023

This information-dense book, edited by two academics and an expert in law, was designed as a “comprehensive exploration of the rapidly growing fields of animal welfare and law” [...]
Antioxidant and Antibacterial Activity of Plant Extracts
Authors: Muntean Delia , Vulpie Silvana
Published: July 2023

Medicinal plants have been a very important source of medicinal products for millennia [...]
Spectator as Witness: Trauma and Testimonio in Contemporary Cuban Art
Authors: Mato Katherine
Published: July 2023

The current scholarship on testimonio largely focusses on its application in literature, failing to address the genre’s possibilities beyond written and spoken narratives. However, voices that exist outside of the literary realm have employed testimonio-driven strategies to produce witness accounts of events and experiences that were previously ignored by or erased from the collective consciousness. Broadening the genre’s scope, this article examines visual manifestations of testimonio in contemporary Cuban and diasporic art, focusing on works by Coco Fusco, Felix González-Torres, and Ana Mendieta that speak to personal and collective experiences of trauma. Experiences associated with exile, displacement, and erasure are particularly relevant to this article, as the artists in focus identify as dissident, immigrant, Latinx, queer, woman, and/or Other. Given the growing interest in accessible approaches to reworking trauma, this article contributes towards the current scholarship on nuanced understandings of healing, ultimately participating in uncovering the complexities of living through and with trauma. The works discussed offer critical reflections related to the AIDS crisis, colonization, and violence against female and Latinx bodies, which have produced personal, collective, and generational traumas that are rarely acknowledged by Western societies. Therefore, by employing a framework centered on testimonio, this article reveals possibilities for marginalized and minoritized spectators to partake in the reworking of trauma through witnessing, while also illuminating, the limitations of art’s healing capabilities for victims.
More than a Man, Less than a Painter: David Smith in the Popular Press, 1938–1966
Authors: Wisotzki Paula
Published: July 2023

Media coverage was vital in establishing the popular reputation of the Abstract Expressionists. Reporting regularly relied on photographic portraits to present these artists as modernist innovators who were an extension of (or even a replacement for) the work of art. Jackson Pollock came to epitomize the Abstract Expressionist artist, with “action” photographs capturing his radical painting method. Pollock’s contemporary, American sculptor David Smith, similarly transformed his medium—in his case by embracing industrial methods to make three-dimensional objects. However, given the constraints inherent in the process of welding he employed, how could Smith’s image be reconstituted as a celebration of artistic individuality so crucial to modernism? The very method Smith embraced to push the boundaries of art kept him from representing the genius creator who channeled the forces of nature to produce culture. By tracing photographs documenting his career published in local and regional newspapers, popular magazines from Popular Science to Life, and mass art magazines from Magazine of Art to Arts, this paper demonstrates that images of Smith at work as an anonymous industrial worker enveloped in protective gear were regularly balanced with images of contemplation—the traditional image of the artist as mediating intelligence. Yet, over the years of his career, the problem of representing Smith was addressed somewhat differently. Early on, there was a tendency to show Smith applying his novel art-making techniques to the production of more traditional objects. During World War II, when Smith was employed as a commercial welder, Smith the artist legitimized reporting on Smith the worker. Finally, in the post-war world—as Smith benefited from the burst of publicity surrounding the triumph of Abstract Expressionism—his rigorous manipulation of metal was celebrated as masculine display, effectively shifting attention away from common industrial labor to heroic individual struggle.
ECG Recordings as Predictors of Very Early Autism Likelihood: A Machine Learning Approach
Authors: Tilwani Deepa , Bradshaw Jessica , Sheth Amit , O’Reilly Christian
Published: July 2023

In recent years, there has been a rise in the prevalence of autism spectrum disorder (ASD). The diagnosis of ASD requires behavioral observation and standardized testing completed by highly trained experts. Early intervention for ASD can begin as early as 1–2 years of age, but ASD diagnoses are not typically made until ages 2–5 years, thus delaying the start of intervention. There is an urgent need for non-invasive biomarkers to detect ASD in infancy. While previous research using physiological recordings has focused on brain-based biomarkers of ASD, this study investigated the potential of electrocardiogram (ECG) recordings as an ASD biomarker in 3–6-month-old infants. We recorded the heart activity of infants at typical and elevated familial likelihood for ASD during naturalistic interactions with objects and caregivers. After obtaining the ECG signals, features such as heart rate variability (HRV) and sympathetic and parasympathetic activities were extracted. Then we evaluated the effectiveness of multiple machine learning classifiers for classifying ASD likelihood. Our findings support our hypothesis that infant ECG signals contain important information about ASD familial likelihood. Amongthe various machine learning algorithms tested, KNN performed best according to sensitivity (0.70 ± 0.117), F1-score (0.689 ± 0.124), precision (0.717 ± 0.128), accuracy (0.70 ± 0.117, p-value = 0.02), and ROC (0.686 ± 0.122, p-value = 0.06). These results suggest that ECG signals contain relevant information about the likelihood of an infant developing ASD. Future studies should consider the potential of information contained in ECG, and other indices of autonomic control, for the development of biomarkers of ASD in infancy.
Biosynthesized Selenium Nanoparticles Using Epigallocatechin Gallate Protect against Pentylenetetrazole-Induced Acute Epileptic Seizures in Mice via Antioxidative, Anti-Inflammatory, and Anti-Apoptotic Activities
Authors: Alrashdi Barakat M. , Fehaid Alaa , Kassab Rami B. , Rizk Sara , Habotta Ola A. , Abdel Moneim Ahmed E.
Published: July 2023

Several negative outcomes are associated with current anti-epileptic medications. Epigallocatechin gallate (EGCG) is a plant-derived compound called catechin and has many medicinal activities, such as anti-inflammatory and antioxidant activities. Biosynthesized selenium nanoparticles are also showing their neuroprotective effect. The anti-epileptic effect of EGCG, alone or with SeNPs, is still debated. Here, we aimed to investigate the potential anti-seizure effect of biosynthesized SeNPs using EGCG (EGCG-SeNPs) against epileptic seizures and hippocampal damage, which is enhanced by pentylenetetrazole (PTZ) injection in mice. Mice were grouped as follows: control; PTZ-exposed group (epileptic model); EGCG + PTZ-treated group; sodium selenite (Na2SeO3) + PTZ-treated group; EGCG-SeNPs + PTZ-treated group; and valproic acid (VPA) + PTZ-treated group. EGCG-SeNPs administration showed anti-epileptic activity by increasing the latency time and reducing the seizure duration following the PTZ injection. Additionally, EGCG-SeNPs counteracted the PTZ-induced changes in oxidants and antioxidants. Moreover, EGCG-SeNPs inhibited the inflammatory response by suppressing the release of pro-inflammatory cytokines and decreasing the immunoreactivity of the glial fibrillary acidic protein and mRNA expression of glutamate receptor subunit zeta-1 (NMDAR; Grin1), showing their inhibitory effect on epilepsy-associated inflammation. Moreover, EGCG-SeNPs reduced PTZ-induced neuronal apoptosis, as indicated by a reduction in the levels of pro-apoptotic proteins and an elevation of the anti-apoptotic protein. Moreover, EGCG-SeNPs administration significantly modulated the PTZ-induced changes in monoamine levels and acetylcholinesterase activity in the hippocampal tissue. The obtained findings suggest the anti-seizure activity of EGCG-SeNPs via their antioxidant, anti-inflammatory, and anti-apoptotic effects, along with their neuromodulatory effect.
Persistence of Hyper-Ramified Microglia in Porcine Cortical Gray Matter after Mild Traumatic Brain Injury
Authors: Grovola Michael R. , Jinich Alan , Paleologos Nicholas , Arroyo Edgardo J. , Browne Kevin D. , Swanson Randel L. , Duda John E. , Cullen D. Kacy
Published: July 2023

Traumatic brain injury (TBI) is a major contributor to morbidity and mortality in the United States as several million people visit the emergency department every year due to TBI exposures. Unfortunately, there is still no consensus on the pathology underlying mild TBI, the most common severity sub-type of TBI. Previous preclinical and post-mortem human studies have detailed the presence of diffuse axonal injury following TBI, suggesting that white matter pathology is the predominant pathology of diffuse brain injury. However, the inertial loading produced by TBI results in strain fields in both gray and white matter. In order to further characterize gray matter pathology in mild TBI, our lab used a pig model (n = 25) of closed-head rotational acceleration-induced TBI to evaluate blood-brain barrier disruptions, neurodegeneration, astrogliosis, and microglial reactivity in the cerebral cortex out to 1 year post-injury. Immunohistochemical staining revealed the presence of a hyper-ramified microglial phenotype—more branches, junctions, endpoints, and longer summed process length—at 30 days post injury (DPI) out to 1 year post injury in the cingulate gyrus (p < 0.05), and at acute and subacute timepoints in the inferior temporal gyrus (p < 0.05). Interestingly, we did not find neuronal loss or astroglial reactivity paired with these chronic microglia changes. However, we observed an increase in fibrinogen reactivity—a measure of blood-brain barrier disruption—predominately in the gray matter at 3 DPI (p = 0.0003) which resolved to sham levels by 7 DPI out to chronic timepoints. Future studies should employ gene expression assays, neuroimaging, and behavioral assays to elucidate the effects of these hyper-ramified microglia, particularly related to neuroplasticity and responses to potential subsequent insults. Further understanding of the brain’s inflammatory activity after mild TBI will hopefully provide understanding of pathophysiology that translates to clinical treatment for TBI.
Biomimetics in Botanical Gardens—Educational Trails and Guided Tours
Authors: Speck Olga , Speck Thomas
Published: July 2023

The first botanical gardens in Europe were established for the study of medicinal, poisonous, and herbal plants by students of medicine or pharmacy at universities. As the natural sciences became increasingly important in the 19th Century, botanical gardens additionally took on the role of public educational institutions. Since then, learning from living nature with the aim of developing technical applications, namely biomimetics, has played a special role in botanical gardens. Sir Joseph Paxton designed rainwater drainage channels in the roof of the Crystal Palace for the London World’s Fair in 1881, having been inspired by the South American giant water lily (Victoria amazonica). The development of the Lotus-Effect® at the Botanical Garden Bonn was inspired by the self-cleaning leaf surfaces of the sacred lotus (Nelumbo nucifera). At the Botanic Garden Freiburg, a self-sealing foam coating for pneumatic systems was developed based on the self-sealing of the liana stems of the genus Aristolochia. Currently, botanical gardens are both research institutions and places of lifelong learning. Numerous botanical gardens provide biomimetics trails with information panels at each station for self-study and guided biomimetics tours with simple experiments to demonstrate the functional principles transferred from the biological model to the technical application. We present eight information panels suitable for setting up education about biomimetics and simple experiments to support guided garden tours about biomimetics.
The Impact of Sales Volume and Limited Quantity on Intertemporal Choice in an Online Consumption Context
Authors: Wang Dawei , Li Jiahui , Wu Qiong , Li Huiyan , Hu Yixin
Published: July 2023

In the context of online consumption, consumers are often faced with a decision between buying now or later. This study examines intertemporal choice by conducting two mixed experimental designs on a total of 206 college students to investigate the impact of combining sales volume and limited quantity on online consumption decisions. Experiment 1 revealed that under unlimited conditions, the same option with high sales volume was relatively more attractive and participants were more inclined to choose it, leading to a herding effect. However, under limited conditions, there was no scarcity effect. Experiment 2 built upon the findings of Experiment 1 and added dynamic change in sales volume. It was found that even with dynamic changes in sales volume, high sales volumes could still lead to a herding effect. In the case of unlimited conditions, dynamic changes in sales offset the effect of sales volume on intertemporal choice. Sales volume and limited quantity are important factors that influence consumers’ purchasing decisions. Therefore, this study combines sales volume and limited quantity and adds dynamic changes in sales to explore individuals’ intertemporal choices in online consumption situations. The findings of the study have significant implications for both merchants and consumers.
Body Mass Index and Physical Fitness among Chinese Adolescents Aged 15–18: A Cross-Sectional Study of Gender Differences
Authors: Liu Guoqing , Hao Rongkai , Li Xiaotian , Gao Yucheng , Li Wenjie , Zhang Meijie
Published: July 2023

Objective: The aim of this study is to examine the relationship between varying levels of obesity and physical fitness test scores among Chinese adolescents, while also investigating gender differences in physical fitness and overall health. Data on height, weight, 50 m sprints, 1000/800 m runs, standing long jumps, sit and reach exercises, pull-ups/bent-leg sit-ups, and additional variables were collected from the DYH health database. Physical fitness indicators were evaluated based on the revised 2014 National Physical Fitness Standards for Students, and scores were assigned accordingly. An ordinal logistic regression (ologit) model was employed to analyze the relationship between body mass index (BMI) and physical fitness. Results: (1) Normal-weight boys achieved significantly higher physical fitness test scores than boys in other weight categories. (2) Underweight and normal-weight girls obtained significantly higher physical fitness test scores compared to overweight and obese girls, with underweight girls scoring slightly higher than those with a normal weight. Conclusions: (1) There is a significant non-linear relationship between BMI levels and physical fitness test scores. (2) Gender differences were observed in physical fitness and overall health outcome. (3) The findings indicate an inverted U-shaped association between BMI and physical fitness among boys, while girls displayed an inverse relationship. This could be attributed to the cultural association between thinness and beauty among girls in China.
Arbitrage Equilibrium, Invariance, and the Emergence of Spontaneous Order in the Dynamics of Bird-like Agents
Authors: Sivaram Abhishek , Venkatasubramanian Venkat
Published: July 2023

The physics of active biological matter, such as bacterial colonies and bird flocks, exhibiting interesting self-organizing dynamical behavior has gained considerable importance in recent years. Current theoretical advances use techniques from hydrodynamics, kinetic theory, and non-equilibrium statistical physics. However, for biological agents, these approaches do not seem to recognize explicitly their critical feature: namely, the role of survival-driven purpose and the attendant pursuit of maximum utility. Here, we propose a game-theoretic framework, statistical teleodynamics, that demonstrates that the bird-like agents self-organize dynamically into flocks to approach a stable arbitrage equilibriumof equal effective utilities. This is essentially the invisible handmechanism of Adam Smith’s in an ecological context. What we demonstrate is for ideal systems, similar to the ideal gas or Ising model in thermodynamics. The next steps would involve examining and learning how real swarms behave compared to their ideal versions. Our theory is not limited to just birds flocking but can be adapted for the self-organizing dynamics of other active matter systems.
Experimental Validation of Damping Adjustment Method with Generator Parameter Study for Wave Energy Conversion
Authors: Pierart Fabian G. , Rubilar Matias , Rohten Jaime
Published: July 2023

Effective control strategies are essential for optimizing wave energy production. While theoretical studies have explored various control approaches, experimental validation of these methods remains limited. This study proposes a damping adjustment method as a means to enable the experimental application of resistive control in wave energy systems. The system’s damping is adjusted through a variable electrical resistance coupled to the generator. A mathematical model is developed to capture the interaction between the wave energy converter, generator, and variable resistance. Experimental validation demonstrates a good fit between the experimental results and the mathematical model. Four different DC machines acting as generators are tested to evaluate the influence of the model’s parameters on control capability. Results indicate that DC machines with less internal resistance allow a wider range of damping and power adjustment by using external resistance. The proposed method shows promising results, emphasizing the significance of the DC machine parameters in achieving effective control over system variables. These findings contribute to the development of efficient and reliable control strategies for enhancing wave energy production at small scales.
An Adaptive Phase Locked Oscillator to Improve the Performance of Fault Recovery from Commutation Failure in LCC-Based HVDC Systems
Authors: Cai Hongda , Li Jing , Zhou Yongzhi , Hu Yishuang
Published: July 2023

An adaptive control of phase lock oscillator (PLO) is proposed to increase the ability of LCC-based HVDC systems to successfully recover from commutation failure, where the dynamic performance during the recovery process is improved. The phase lock oscillator is one of the most important parts of the control system, which is used to trace the phase angle of commutating voltage. However, the PLO with constant parameters cannot provide accurate information under both steady-state operation and large disturbances. In our work, the control parameters of PLO can be adaptively adjusted, following the states of commutating voltage. When the system is operating in a steady state, the PLO selects parameters that exhibit improved small-signal stability, while parameters prioritizing dynamic behaviors with high-tracing accuracy are adopted during large disturbances. Case studies based on simulations in PSCAD/EMTDC and RT-LAB show that the proposed control strategy can improve the performance of fault recovery from CF.
Variable Amplitude Gate Voltage Synchronous Drive Technique for Improving Dynamic Current Balancing in Paralleled IGBTs
Authors: Zhang Junkun , Lei Ertao , Jin Li , Ma Kai , Li Ying , Li Xinwei , Xia Chenyang , Wang Xirui
Published: July 2023

The problem of current sharing imbalance in the parallel connection of IGBT multi-modules affects the wide-scale application of parallel IGBT. The current imbalance problem in the dynamic process is mainly caused by the difference in control loop parameters. In parallel IGBT applications, current sharing is a critical concern. Objective differences in IGBT module and driver circuit parameters, as well as incomplete symmetry in the power circuit, lead to inconsistent parasitic parameters, resulting in both static and dynamic current-sharing issues. Static current sharing refers to the uneven distribution of load current under static operating conditions, while dynamic current sharing refers to the imbalance in current distribution among parallel IGBT modules during turn-on and turn-off processes. This is mainly influenced by the synchronization of turn-on and turn-off timings and the consistency of collector current change rates during these processes. The difference in characteristic parameters of IGBT modules is an important factor leading to the difference in control loop parameters, which has a profound impact on the dynamic current-sharing characteristics of IGBT parallel applications. In the case where the device parameters cannot be changed, some drive compensation controls can compensate for the influence of device differences on dynamic current sharing. Accurate identification of the characteristic parameters of the IGBT module is the key to this method. This paper mainly studies a synchronous variable-amplitude drive scheme and studies the influence of parameters such as synthetic gate resistance, gate-emitter capacitance, and on-off gate threshold voltage on the dynamic current-sharing characteristics. The correlation characteristics of the characteristic parameters of the IGBT device body are studied, and the characteristic model of each parameter and the influencing variable is constructed. The parallel working model of PSpice devices is established, and the influence of different characteristic parameters on the current-sharing characteristics is evaluated, and its sensitivity is summarized through simulation analysis. Through the 1700 V/300 A IGBT parallel switch characteristic experiment, the current sharing effectiveness of the synchronous variable amplitude driving method is verified. Finally, the effects of different gate control voltages and different action times on the dynamic current-sharing characteristics are summarized.
Effect of a Bacillus Probiotic Compound on Penaeus vannamei Survival, Water Quality, and Microbial Communities
Authors: Hu Xiaojuan , Xu Yu , Su Haochang , Xu Wujie , Wen Guoliang , Xu Chuangwen , Yang Keng , Zhang Song , Cao Yucheng
Published: July 2023

Given the widespread use of commercial probiotics in aquaculture, it is important to evaluate the quality and environmental effects of these additives. Here, the effects of a Bacillus probiotic compound, BG4, on Penaeus vannamei survival rate, water quality factors, and microbial communities were assessed. An analysis of the BG4 powder confirmed the content of probiotic bacteria: 50.2% Bacillus licheniformis, 48.4% Bacillus subtilis, and 1.4% Bacillus amyloliquefaciens, consistent with the information on the product packaging. The effective bacterial quantity (1.1 × 109 CFU/g) was higher than that indicated on the product label (2 × 108 CFU/g). BG4 was added to a sterilized aquaculture water system, according to the indicated bacterial quantity; after 7 days, the maximum ammonia nitrogen, phosphate, and chemical oxygen demand degradation rates were 36.3%, 28.9%, and 15.2%, respectively. In the shrimp culture experiment, the survival rate of P. vannamei and water quality did not differ significantly between the BG4 and control groups. The bacterial quantity and high-throughput sequencing results indicated that Bacillus content in BG4 group decreased continuously from 3.5 × 104 CFU/mL to 6.9 × 102 CFU/mL. To ensure the desired effect of probiotics in commercial aquaculture applications, additional quality evaluations and scientific assessments are needed.
Effect of Stir-Frying on Physicochemical and Functional Properties of Oat Protein Isolates
Authors: Wang Xia , Lei Yang , Rafique Hamad , Zou Liang , Hu Xinzhong
Published: July 2023

The heat treatment required for the deactivation of enzymes was carried out on crop species such as oats. Stir-frying, a frequently employed method for enzyme inactivation to preserve their desirable shelf life, can result in diminished nutritional value and protein degeneration. The mechanism by which stir-frying affects the oat protein remains largely unknown. Therefore, this study aimed to investigate the physicochemical and functional properties of the extracted oat protein isolates (OPI) at different stir-frying durations (0, 10, 20, and 30 min) at a temperature of 230 °C. The findings of this study demonstrated that stir-frying led to a decrease in the content of amino acids (AA), potentially attributed to the involvement of certain amino acids in the Maillard reaction. As the time of stir-frying increased, the secondary structure of OPI underwent changes: specifically, β-turns transformed into β-sheets. The process of protein denaturation and redistribution of chemical bonds resulted in an increase in the disulfide bond content of OPI, leading to aggregation, large particle size, and reduced digestibility. However, the water retention properties, foaming properties, and emulsification properties of OPI showed improvement. These findings provide valuable insights for the controlled and precise processing of oats and highlight the potential of OPI as a functional food.
What Drives the Ionized Gas Outflows in Radio-Quiet AGN?
Authors: Singha Mainak , O’Dea Christopher P. , Baum Stefi A.
Published: July 2023

We review the mechanisms driving the ionized gas outflows in radio-quiet (RQ) AGN. Although it constitutes ∼90% of the AGN population, what drives these outflows in these AGNs remains an open question. High-resolution imaging and integral field unit (IFU) observation is key to spatially resolving these outflows, whereas radio observations are important to comprehend the underlying radiative processes. Radio interferometric observations have detected linear, collimated structures on the hundreds of pc scale in RQ AGN, which may be very similar to the extended radio jets in powerful galaxies. Proper motions measured in some objects are sub-relativistic. Other processes, such as synchrotron radiation from shock-accelerated gas around the outflows could give rise to radio emissions as well. Near the launching region, these outflows may be driven by the thermal energy of the accretion disk and exhibit free–free emission. IFU observations on the other hand have detected evidence of both winds and jets and the outflows driven by them in radio-quiet AGN. Some examples include nearby AGN such as Mrk 1044 and HE 1353-1917. An IFU study of nearby (z <0.06) RQ AGN has found that these outflows may be related to their radio properties on <100 pc scale, rather than their accretion properties. Recent JWST observations of RQ AGN XID 2028 have revealed that radio jets and wind could inflate bubbles, create cavities, and trigger star formation. Future high-resolution multi-wavelength observations and numerical simulations taking account of both jets and winds are hence essential to understand the complex interaction between radio-quiet AGN and the host from sub-pc to kpc scales.
South Asian COVID-19 Memoirs: Mourning and Erasure of “Grievable Lives”
Authors: Basu Lopamudra
Published: July 2023

This article analyzes how narratives about the COVID-19 pandemic are beginning to memorialize lives lost in the crisis. It juxtaposes the author’s personal experience of the loss of family members with emerging memoirs by South Asian women to explore the diversity of genres like the lyric essay and the graphic memoir that memorialize lives lost to COVID-19. While acknowledging that the current pandemic and its effects are far from over, the essay argues that these memoirs are a conscious attempt to mourn and thereby restore the humanity of lives robbed of traditional acts of remembrance due to the isolation and bureaucracy of laws governing COVID-19 deaths and funerals. These texts by Barkha Dutt, Kay Sohini, and Jhumpa Lahiri are exceptional because the great majority of deaths during this time have been consigned to erasure, lack of documentation, or censorship. These texts are resisting the dominant trend to leave the pandemic behind and resume normal lives. By committing to grief instead of a facile recuperation, these memoirs are not just charting a private path of healing but also transforming private grief into a statement of shared suffering and solidarity, even when the pandemic has affected individuals differently based on stratifications of race, class, and privilege.
Factors Associated with Depression in Infertile Couples: A Study in Thailand
Authors: Yang Tong , Wongpakaran Nahathai , Wongpakaran Tinakon , Saeng-Anan Ubol , Singhapreecha Charuk , Jenraumjit Rewadee , Peisah Carmelle
Published: July 2023

Background: Infertility can affect a couple’s mental health and marital and social relationships. The study aimed to investigate the prevalence of depression among infertile couples and their relationships with other factors. Methods: This study employed a cross-sectional survey. Validated tools were used to assess anxiety and depression, marital satisfaction, personality traits and sufficiency economy. The actor–partner interdependence model (APIM) was used for dyadic analysis. Results: The prevalence of depression in infertile couples was 6.7%. Aggression, extraversion and neuroticism were significantly correlated with depression, whereas the expectation of having children, marital satisfaction and sufficiency economy were negatively correlated with depression. The APIM model suggested that neuroticism and marital satisfaction were significant predictors of depression. Partner effect between the expectation of having children and depression was observed (p = 0.039). Conclusions: Like other populations, depression in infertile couples seems to be associated with aggression, extraversion and neuroticism. However, there are specific variables related to infertility that impact the depression levels of these couples. For instance, the expectation of having children can affect the partners of infertile couples, while the role of the sufficiency economy is a new factor that has been examined for depression in this sample and requires further exploration.
Advanced Treatment of Coking Wastewater by Polyaluminum Silicate Sulfate for Organic Compounds Removal
Authors: Wang Jiangnan , Chang Fang , Zheng Maosheng
Published: July 2023

Coking wastewater is a typical high-strength organic wastewater, for which it is difficult to meet discharging standards with a single biological treatment. In this study, effective advanced treatment of coking wastewater was achieved by coagulation with freshly prepared polyaluminum silicate sulfate (PASS). The performance advantage was determined through comparison with commercial coagulants including ferric chloride, polyferric sulfate, aluminum sulfate and polyaluminum chloride. Both single-factor and Taguchi experiments were conducted to determine the optimal conditions for coagulation with CODCr and UV254 as indicators. A dosage of 7 mmol/L PASS, flocculation velocity of 75 r/min, flocculation time of 30 min, pH of 7, and temperature of 20 °C could decrease the CODCr concentration from 196.67 mg/L to 59.94 mg/L. Enhanced coagulation could further help to remove the organic compounds, including pre-oxidation with ozonation, adsorption with activated carbon, assistant coagulation with polyacrylamide and secondary coagulation. UV spectrum scanning and gas chromatography-mass spectrometry revealed that the coagulation process effectively removed the majority of organic compounds, especially the high molecular weight alkanes and heterocyclic compounds. Coagulation with PASS provides an effective alternative for the advanced treatment of coking wastewater.
Editorial of Special Issue “Molecular Mechanisms of Allergy and Asthma 2.0”
Authors: Potaczek Daniel P.
Published: July 2023

Similarly to the previous Special Issue entitled “Molecular Mechanisms of Allergy and Asthma” [...]