bluuebunny/crossref_metadata_2025 huggingface dataset:
Vertebral Body Tethering in 49 Adolescent Patients after Peak Height Velocity for the Treatment of Idiopathic Scoliosis: 2–5 Year Follow-Up
Authors: Meyers James , Eaker Lily , Zhang Jessica , di Pauli von Treuheim Theodor , Lonner Baron
Published: June 2022

Vertebral Body Tethering (VBT) is a non-fusion surgical treatment for Adolescent Idiopathic Scoliosis (AIS) that elicits correction via growth modulation in skeletally immature patients. VBT after peak height velocity is controversial and is the subject of this study. A retrospective review of Risser 3–5 AIS patients treated with VBT, and min. 2-year FU was performed. Pre to post-op changes in clinical outcomes were compared using Student’s t-test or the Mann-Whitney test. A total of 49 patients met criteria, age 15.0 ± 1.9 years, FU 32.5 ± 9.1 months. For thoracic (T) major curvatures, T curvature improved from 51.1 ± 6.9° to 27.2° ± 8.1° (p < 0.01) and TL from 37.2° ± 10.7° to 19.2° ± 6.8° (p < 0.01). For thoracolumbar (TL) major curvatures, T improved from 37.2° ± 10.7° to 18.8° ± 9.4° (p < 0.01) and TL from 49.0° ± 6.4° to 20.1° ± 8.5° (p < 0.01). Major curve inclinometer measurements and SRS-22 domains, except activity, improved significantly (p ≤ 0.05). At the latest FU, one (2%) patient required fusion of the T curve and revision of the TL tether due to curve progression in the previously uninstrumented T curve and tether breakage (TB) in the TL. Twenty (41%) patients experienced TB. VBT in AIS patients with limited remaining skeletal growth resulted in satisfactory clinical outcomes at the latest FU.
The Impact of Withdrawn vs. Agitated Relatives during Resuscitation on Team Workload: A Single-Center Randomised Simulation-Based Study
Authors: Sellmann Timur , Oendorf Andrea , Wetzchewald Dietmar , Schwager Heidrun , Thal Serge Christian , Marsch Stephan
Published: June 2022

Background: Guidelines recommend that relatives be present during cardiopulmonary resuscitation (CPR). This randomised trial investigated the effects of two different behaviour patterns of relatives on rescuers’ perceived stress and quality of CPR. Material and methods: Teams of three to four physicians were randomised to perform CPR in the presence of no relatives (control group), a withdrawn relative, or an agitated relative, played by actors according to a scripted role, and to three different models of leadership (randomly determined by the team or tutor or left open). The scenarios were video-recorded. Hands-on time was primary, and the secondary outcomes comprised compliance to CPR algorithms, perceived workload, and the influence of leadership. Results: 1229 physicians randomised to 366 teams took part. The presence of a relative did not affect hands-on time (91% [87–93] vs. 92% [88–94] for “withdrawn” and 92 [88–93] for “agitated” relatives; p = 0.15). The teams interacted significantly less with a “withdrawn” than with an “agitated” relative (11 [7–16]% vs. 23 [15–30]% of the time spent for resuscitation, p < 0.01). The teams confronted with an “agitated” relative showed more unsafe defibrillations, higher ventilation rates, and a delay in starting CPR (all p < 0.05 vs. control). The presence of a relative increased frustration, effort, and perceived temporal demands (all <0.05 compared to control); in addition, an “agitated” relative increased mental demands and total task load (both p < 0.05 compared to “withdrawn” and control group). The type of leadership condition did not show any effects. Conclusions: Interaction with a relative accounted for up to 25% of resuscitation time. Whereas the presence of a relative per se increased the task load in different domains, only the presence of an “agitated” relative had a marginal detrimental effect on CPR quality (GERMAN study registers number DRKS00024761).
Comparison between Deep-Learning-Based Ultra-Wide-Field Fundus Imaging and True-Colour Confocal Scanning for Diagnosing Glaucoma
Authors: Shin Younji , Cho Hyunsoo , Shin Yong Un , Seong Mincheol , Choi Jun Won , Lee Won June
Published: June 2022

In this retrospective, comparative study, we evaluated and compared the performance of two confocal imaging modalities in detecting glaucoma based on a deep learning (DL) classifier: ultra-wide-field (UWF) fundus imaging and true-colour confocal scanning. A total of 777 eyes, including 273 normal control eyes and 504 glaucomatous eyes, were tested. A convolutional neural network was used for each true-colour confocal scan (Eidon AF™, CenterVue, Padova, Italy) and UWF fundus image (Optomap™, Optos PLC, Dunfermline, UK) to detect glaucoma. The diagnostic model was trained using 545 training and 232 test images. The presence of glaucoma was determined, and the accuracy and area under the receiver operating characteristic curve (AUC) metrics were assessed for diagnostic power comparison. DL-based UWF fundus imaging achieved an AUC of 0.904 (95% confidence interval (CI): 0.861–0.937) and accuracy of 83.62%. In contrast, DL-based true-colour confocal scanning achieved an AUC of 0.868 (95% CI: 0.824–0.912) and accuracy of 81.46%. Both DL-based confocal imaging modalities showed no significant differences in their ability to diagnose glaucoma (p = 0.135) and were comparable to the traditional optical coherence tomography parameter-based methods (all p > 0.005). Therefore, using a DL-based algorithm on true-colour confocal scanning and UWF fundus imaging, we confirmed that both confocal fundus imaging techniques had high value in diagnosing glaucoma.
Brain Tissue Damage Induced by Multimodal Neuromonitoring In Situ during MRI after Severe Traumatic Brain Injury: Incidence and Clinical Relevance
Authors: Pinggera Daniel , Rhomberg Paul , Beer Ronny , Thomé Claudius , Petr Ondra
Published: June 2022

Both neuromonitoring and early magnetic resonance imaging (MRI) provide crucial information for treatment management and prognosis in patients with severe traumatic brain injury (sTBI). So far, neuromonitoring in situ impedes the routine implementation of MRI due to safety concerns. We aimed to evaluate the brain tissue damage induced by inserted neuromonitoring devices and its clinical relevance. Nineteen patients with sTBI and being exposed to at least one MRI with neuromonitoring in situ and one follow-up MRI after neuromonitoring removal were analyzed. All MRIs were reviewed for specific tissue damage. Three females and sixteen males (aged 20–74 years, mean 42.8 years) with an initial median GCS of 5 (range 3–8) were analyzed. No lesion was observed in six patients (31.6%), whereas another six patients (31.6%) demonstrated a detectable probe trajectory. Probe-related tissue damage was visible in seven patients (36.8%) with the size of the lesion prone to further enlarge with increasing cumulative duration of MRI examinations. Upon interdisciplinary evaluation, the lesions were not considered clinically relevant. Neuromonitoring probes in situ during MRI examinations may cause local brain tissue damage, yet without any clinical implications if placed correctly. Therefore, indications must be strictly based on joint decision from all involved disciplines.
Skeletal, Dental and Soft Tissue Cephalometric Changes after Orthodontic Treatment of Dental Class II Malocclusion with Maxillary First Molar or First Premolar Extractions
Authors: Booij Johan Willem , Serafin Marco , Fastuca Rosamaria , Kuijpers-Jagtman Anne Marie , Caprioglio Alberto
Published: June 2022

The aim of the present retrospective study was evaluating skeletal, dental and soft tissue changes of two groups of Class II patients orthodontically treated with extractions of upper first premolars (U4 group) and upper first molars (U6 group). In total, 21 patient records (9M and 12F; mean age 12.5 ± 1.2 years) were selected for the U4 group, and 38 patient records (17M and 21F; mean age 13.2 ± 1.3 years) were recruited for the U6 group. Twenty cephalometric variables were analysed on standardised lateral cephalograms at baseline (T0) and at the end of orthodontic treatment (T1). Means and standard deviations (SDs) were calculated for both groups and increments were calculated. After revealing the normal distribution of data with the Shapiro–Wilk test, Student’s t-test was used to compare variables at T0 between groups. A paired t-test was used to analyse changes between time points within each group, and Student’s t-test to compare differences between groups at T1. Both groups showed a significant increase in the distance among upper second molars and the vertical pterygoid line (PTV-maxillary second molar centroid U6 group: 6.66 ± 5.00 mm; U4 group: 3.66 ± 2.20 mm). Moreover, the distance of upper incisors to the palatal plane significantly increased (PP-maxillary incisor tip U6 group: 1.09 ± 1.52 mm; U4 group: 0.20 ± 2.00 mm; p = 0.061). Significant changes were found for overjet (U6 group: −4.86 ± 1.62 mm; U4 group: −3.27 ± 1.90 mm; p = 0.001). The distance between upper lip and esthetic plane showed a significantly reduction in both groups (ULip-E Plane U6 group: −2.98 ± 1.65 mm; U4 group: −1.93 ± 1.57 mm). No statistically significant changes were found in sagittal or vertical skeletal values. The significantly larger reduction of upper lip protrusion and overjet in the U6 group compared to the U4 group suggests preferring molar extraction treatment for severe Class II with protrusive soft tissues’ profile and increased overjet. Since no differences on vertical values were found, an increased SN^GoGn angle should not be considered a discriminating factor for choosing molar extraction treatment.
Efficacy of Chenodeoxycholic Acid and Ursodeoxycholic Acid Treatments for Refractory Functional Dyspepsia
Authors: Jang Sung Ill , Lee Tae Hoon , Jeong Seok , Kwon Chang-Il , Koh Dong Hee , Kim Yoon Jae , Lee Hye Sun , Do Min-Young , Cho Jae Hee , Lee Dong Ki
Published: June 2022

Refractory functional dyspepsia (RFD) is diagnosed when symptoms persist for at least 6 months despite at least two medical treatments. No consensus treatment guidelines exist. The implicated causes of functional biliary dyspepsia are a narrowed cystic duct, Sphincter of Oddi dysfunction, microlithiasis, and gallbladder dyskinesia. We investigated the treatment effects of litholytic agents. RFD patients were prospectively enrolled in six tertiary medical centers. All subjects took chenodeoxycholic and ursodeoxycholic acids (CNU) twice daily for 12 weeks. We monitored their medication adherence, laboratory results, and complications. The 7-point global symptom scale test scores were determined before and after treatment. Of the 52 patients who were prospectively screened, 37 were included in the final analysis. The mean age was 51.3 years: 14 were males, and 23 were females. Before treatment, the mean number and duration of symptoms were 2.4 and 48.2 months, and a mean of 3.3 FD-related drugs were taken. The mean CNU adherence was 95.3%. The mean global symptom scale score decreased from 5.6 pretreatment to 2.6 posttreatment. The symptom improvement rate was 94.6% (35 out of 37 patients). The only adverse event was mild diarrhea (10.8%) that was resolved after conservative management. Conclusions: CNU improved the symptoms of RFD patients who did not respond to conventional medications. Litholytic agents are good treatment options for patients with RFD and biliary dyspepsia secondary to biliary microlithiasis. Further prospective, large-scale mechanistic studies are warranted.
Rational Design and Characterisation of Novel Mono- and Bimetallic Antibacterial Linde Type A Zeolite Materials
Authors: Oheix Emmanuel , Reicher Chloé , Nouali Habiba , Michelin Laure , Josien Ludovic , Daou T. Jean , Pieuchot Laurent
Published: June 2022

The development of antimicrobial devices and surfaces requires the setup of suitable materials, able to store and release active principles. In this context, zeolites, which are microporous aluminosilicate minerals, hold great promise, since they are able to serve as a reservoir for metal-ions with antimicrobial properties. Here, we report on the preparation of Linde Type A zeolites, partially exchanged with combinations of metal-ions (Ag+, Cu2+, Zn2+) at different loadings (0.1–11.9 wt.%). We combine X-ray fluorescence, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and X-ray diffraction to monitor the metal-ion contents, distribution, and conservation of the zeolite structure after exchange. Then, we evaluate their antimicrobial activity, using agar dilution and optical-density monitoring of Escherichia coli cultures. The results indicate that silver-loaded materials are at least 70-fold more active than the copper-, zinc-, and non-exchanged ones. Moreover, zeolites loaded with lower Ag+ concentrations remain active down to 0.1 wt.%, and their activities are directly proportional to the total Ag content. Sequential exchanges with two metal ions (Ag+ and either Cu2+, Zn2+) display synergetic or antagonist effects, depending on the quantity of the second metal. Altogether, this work shows that, by combining analytical and quantitative methods, it is possible to fine-tune the composition of bi-metal-exchanged zeolites, in order to maximise their antimicrobial potential, opening new ways for the development of next-generation composite zeolite-containing antimicrobial materials, with potential applications for the design of dental or bone implants, as well as biomedical devices and pharmaceutical products.
Hierarchical Optimization of Oil Spill Response Vessels in Cases of Accidental Pollution of Bays and Coves
Authors: Đorđević Marko , Mohović Đani , Krišković Antoni , Legović Tarzan
Published: June 2022

Ships pollute bays and coves with oils daily. Although the number of major pollution events is decreasing, accidents still occur and are likely to occur in the future. Most often, pollution arises from spills of non-persistent oil in bays, mainly during the summer season. A prompt response is key to oil collection success in semi-enclosed waters. In order to ensure that oil does not reach the mainland and endanger a potentially crucial economic resource of a country, it is vital to collect it in minimal time. Furthermore, it is also essential to send response ships that minimize the cost. In practice, there may be several optimal combinations of response ships to be sent. When the response cost is considered, obtaining all possible optimal solutions (a complete Pareto front) is vital because the shortest collection time does not necessarily mean the lowest costs. For these reasons, two general optimization models are considered. The first model gives the minimum response time to collect oil from the sea’s surface, while the second model gives the minimum response cost of ships participating in the clean-up operation. The supplied pseudo-codes allow for all optimal solutions to be found.
Recent Progress in Modeling and Control of Bio-Inspired Fish Robots
Authors: Sun Boai , Li Weikun , Wang Zhangyuan , Zhu Yunpeng , He Qu , Guan Xinyan , Dai Guangmin , Yuan Dehan , Li Ang , Cui Weicheng , Fan Dixia
Published: June 2022

Compared with traditional underwater vehicles, bio-inspired fish robots have the advantages of high efficiency, high maneuverability, low noise, and minor fluid disturbance. Therefore, they have gained an increasing research interest, which has led to a great deal of remarkable progress theoretically and practically in recent years. In this review, we first highlight our enhanced scientific understanding of bio-inspired propulsion and sensing underwater and then present the research progress and performance characteristics of different bio-inspired robot fish, classified by the propulsion method. Like the natural fish species they imitate, different types of bionic fish have different morphological structures and distinctive hydrodynamic properties. In addition, we select two pioneering directions about soft robotic control and multi-phase robotics. The hybrid dynamic control of soft robotic systems combines the accuracy of model-based control and the efficiency of model-free control, and is considered the proper way to optimize the classical control model with the intersection of multiple machine learning algorithms. Multi-phase robots provide a broader scope of application compared to ordinary bionic robot fish, with the ability of operating in air or on land outside the fluid. By introducing recent progress in related fields, we summarize the advantages and challenges of soft robotic control and multi-phase robotics, guiding the further development of bionic aquatic robots.
Optimization through a Box–Behnken Experimental Design of the Microwave-Assisted Extraction of the Psychoactive Compounds in Hallucinogenic Fungi (Psylocibe cubensis)
Authors: Polo-Castellano Curro , Álvarez José Á. , Palma Miguel , Barbero Gerardo F. , Ayuso Jesús , Ferreiro-González Marta
Published: June 2022

Hallucinogenic fungi, mainly those from the Psilocybe genus, are being increasingly consumed even though there is no control on their culture conditions. Due to the therapeutic potential as antidepressants and anxiolytics of the alkaloids that they produce (psilocin and psilocybin), some form of control on their production would be highly recommended. Prior to identifying their optimal culture condition, a methodology that allows their study is required. Microwave-assisted extraction method (MAE) is a technique that has proven its efficiency to extract different compounds from solid matrices. For this reason, this study intends to optimize a MAE method to extract the alkaloids found in Psylocibe cubensis. A surface-response Box–Behnken design has been employed to optimize such extraction method and significantly reduce time and other resources in the extraction process. Based on the Box–Behnken design, 50 °C temperature, 60% methanol as extraction solvent, 0.6 g:10 mL sample mass:solvent ratio and 5 min extraction time, were established as optimal conditions. These mild conditions, combined with a rapid and efficient UHPLC analysis result in a practical and economical methodology for the extraction of psilocin and psilocybin from Psylocibe cubensis.
Metabolic Profiling in Rheumatoid Arthritis, Psoriatic Arthritis, and Psoriasis: Elucidating Pathogenesis, Improving Diagnosis, and Monitoring Disease Activity
Authors: Dorochow Erika , Köhm Michaela , Hahnefeld Lisa , Gurke Robert
Published: June 2022

Immune-mediated inflammatory diseases (IMIDs), such as rheumatoid arthritis (RA), psoriatic arthritis (PsA), and psoriasis (Ps), represent autoinflammatory and autoimmune disorders, as well as conditions that have an overlap of both categories. Understanding the underlying pathogeneses, making diagnoses, and choosing individualized treatments remain challenging due to heterogeneous disease phenotypes and the lack of reliable biomarkers that drive the treatment choice. In this review, we provide an overview of the low-molecular-weight metabolites that might be employed as biomarkers for various applications, e.g., early diagnosis, disease activity monitoring, and treatment-response prediction, in RA, PsA, and Ps. The literature was evaluated, and putative biomarkers in different matrices were identified, categorized, and summarized. While some of these candidate biomarkers appeared to be disease-specific, others were shared across multiple IMIDs, indicating common underlying disease mechanisms. However, there is still a long way to go for their application in a routine clinical setting. We propose that studies integrating omics analyses of large patient cohorts from different IMIDs should be performed to further elucidate their pathomechanisms and treatment options. This could lead to the identification and validation of biomarkers that might be applied in the context of precision medicine to improve the clinical outcomes of these IMID patients.
Factors Associated with Postpartum Sexual Dysfunction in Spanish Women: A Cross-Sectional Study
Authors: Hidalgo-Lopezosa Pedro , Pérez-Marín Sandra , Jiménez-Ruz Andrea , López-Carrasco Juan de la Cruz , Cubero-Luna Ana María , García-Fernández Rubén , Rodríguez-Borrego María Aurora , Liébana-Presa Cristina , López-Soto Pablo Jesús
Published: June 2022

(1) Background: Female sexual dysfunction (FSD) has a high prevalence globally, and perinatal factors favor FSD, especially in the postpartum period. The aim was to determine the prevalence and factors influencing FSD in the postpartum period; (2) Methods: An observational study carried out in three primary care centers in southern Spain, with women in the postpartum period who had a single low-risk birth. One hundred and seventeen women answered the Female Sexual Function questionnaire during the 4th month postpartum, between January 2020 and December 2021. Sociodemographic, obstetric, neonatal variables and level of self-esteem were analyzed. A multiple logistic regression model was carried out; (3) Results: 78.4% had high level of self-esteem. FSD prevalence was 89.7%. Factors related to FSD were having an instrumental vaginal delivery, women with university studies, and prenatal preparation. Maternal age ≥ 35, multiparity, pathological processes in the child, a medium–low level of self-esteem and newborn weight were associated with disorders in some of domains of sexual function; (4) Conclusions: FSD is highly prevalent in the postpartum period and is associated with preventable factors. A preventive approach by health professionals to these factors is essential. Health services should implement postpartum follow-up programs, which may coincide in time and place with newborn follow-up programs.
Seeking out SDGs in Dialysis Medicine—Selected Articles from the JSDT Conference, Yokohama 2022
Authors: Tsuchiya Ken
Published: June 2022

The 67th Annual Meeting of the Japanese Society for Dialysis Therapy (JSDT) was held in Yokohama City from 1 to3 July, 2022 [...]
Analysis of Technological Heredity in the Production of Rolling Bearing Rings Made of AISI 52100 Steel Based on Waviness Measurements
Authors: Zmarzły Paweł
Published: June 2022

The production of rolling bearings is a complicated process that requires the use of many operations. The manufactured elements of rolling bearings should be of high quality while minimizing production costs. Despite many research studies related to the analysis of technological processes, there is still a lack of research and tools allowing us to satisfactorily assess the relationships between individual operations of the rolling bearing ring process of production and the quality. To perform such an assessment, one can use the concept of technological heredity phenomenon analysis. As the surface waviness of the bearing race is of key importance, the present paper aims at evaluating how the individual technological operations of the rolling bearing ring production process affect the formation of their surface waviness. The surface waviness of the bearing race was measured in both directions (two sections), i.e., along the circumference using the Talyrond 365 measurement system and across the circumference of the race using Talysurf PGI. The production of 6308-2z rolling bearings made of AISI (American Iron and Steel Institute) 52100 bearing steel was analyzed. The occurrence of the phenomenon of technological heredity in the production of rolling bearings was observed. The research results indicate that the turning operation reduces the surface waviness of the bearing rings obtained after forging, while the heat treatment causes a slight increase in surface waviness. On the other hand, grinding operation significantly reduces the waviness, with this reduction being greater for the outer ring. Furthermore, the research has shown that the waviness of the surface is an inheritance factor caused by individual operations of the rolling bearing rings manufacturing process.
Reduced Cardiotoxicity of Ponatinib-Loaded PLGA-PEG-PLGA Nanoparticles in Zebrafish Xenograft Model
Authors: Al-Thani Hissa F. , Shurbaji Samar , Zakaria Zain Zaki , Hasan Maram H. , Goracinova Katerina , Korashy Hesham M. , Yalcin Huseyin C.
Published: June 2022

Tyrosine kinase inhibitors (TKIs) are the new generation of anti-cancer drugs with high potential against cancer cells’ proliferation and growth. However, TKIs are associated with severe cardiotoxicity, limiting their clinical value. One TKI that has been developed recently but not explored much is Ponatinib. The use of nanoparticles (NPs) as a better therapeutic agent to deliver anti-cancer drugs and reduce their cardiotoxicity has been recently considered. In this study, with the aim to reduce Ponatinib cardiotoxicity, Poly(D,L-lactide-co-glycolide)-b-poly(ethyleneoxide)-b-poly(D,L-lactide-co-glycolide) (PLGA-PEG-PLGA) triblock copolymer was used to synthesize Ponatinib in loaded PLGA-PEG-PLGA NPs for chronic myeloid leukemia (CML) treatment. In addition to physicochemical NPs characterization (NPs shape, size, size distribution, surface charge, dissolution rate, drug content, and efficacy of encapsulation) the efficacy and safety of these drug-delivery systems were assessed in vivo using zebrafish. Zebrafish are a powerful animal model for investigating the cardiotoxicity associated with anti-cancer drugs such as TKIs, to determine the optimum concentration of smart NPs with the least side effects, and to generate a xenograft model of several cancer types. Therefore, the cardiotoxicity of unloaded and drug-loaded PLGA-PEG-PLGA NPs was studied using the zebrafish model by measuring the survival rate and cardiac function parameters, and therapeutic concentration for in vivo efficacy studies was optimized in an in vivo setting. Further, the efficacy of drug-loaded PLGA-PEG-PLGA NPs was tested on the zebrafish cancer xenograft model, in which human myelogenous leukemia cell line K562 was transplanted into zebrafish embryos. Our results demonstrated that the Ponatinib-loaded PLGA-PEG-PLGA NPs at a concentration of 0.001 mg/mL are non-toxic/non-cardio-toxic in the studied zebrafish xenograft model.
Potential of Waste Marble Sludge for Repressing Alkali-Silica Reaction in Concrete with Reactive Aggregates
Authors: Ahmed Ali , Abbas Safeer , Abbass Wasim , Waheed Ayesha , Razzaq Afia , Ali Elimam , Deifalla Ahmed Farouk
Published: June 2022

The continuous development of the marble industry has led to an increase in the accumulation of waste marble sludge causing landfilling and health-associated issues. The intention of the current study is to explore the potential of waste marble sludge powder (MS) utilization as a means of controlling alkali-silica reaction (ASR) in concrete. Specimen (cubes, prisms, and mortar bars) were prepared to incorporate reactive aggregates and various proportions of MS ranging from 5% to 40% as a replacement for aggregates. Expansion and mechanical strength characteristics were determined to investigate the effectiveness of MS to control ASRfor up to 150 days. Results revealed that on replacing aggregates in the control specimen with 25% MS, the ASR expansion at 14 days reduced from 0.23% to 0.17%, and the expansion at 28 days reduced from 0.28% to 0.17% which is within limits as per American Standard for Testing of Materials (ASTM) C1260. Furthermore, specimens incorporating MS exhibited improved compressive and flexural strength as compared to the identical specimen without MS. Microstructural analysis using Scanning electron microscopy (SEM) revealed micro-cracks in the control specimen while the specimen incorporating MS was found intact. Thus, it can be foreseen that the use of MS as a partial replacement of aggregates can control ASR in concrete as well as reduce the dumping and harmful emissions issue.
Electrochemical Reduction of La2O3, Nd2O3, and CeO2 in LiCl-Li2O Melt
Authors: Shishkin Alexey V. , Shishkin Vladimir Yu. , Pankratov Aleksandr A. , Burdina Anna A. , Zaikov Yuriy P.
Published: June 2022

The reduction of pellets composed of individual CeO2, Nd2O3 and a La2O3-Nd2O3-CeO2 mixture by lithium extracted on a cathode during lithium chloride electrolysis at 650 °C was studied. The methods of cyclic voltammetry, electron microscopy, including determination of the elemental composition of the studied objects, and X-ray diffraction analysis were applied for the present study. The reduction degree of rare-earth metal (REM) oxides was determined using both the bromine method and reduction melting of the samples in the graphite crucible. The formation of the metallic phase composed of the rare-earth elements (REEs) was not observed even at the cathode potentials, corresponding to the formation of the liquid alkali metal phase, and lithium extraction, which, in the quantitative ratio, exceeds greatly the values needed for the reduction reaction. CeO2 was found to reduce to Ce2O3.
Study on the Actuating Performance of an Embedded Macro Fiber Composite Considering the Shear Lag Effect
Authors: Wei Jianhui , Gao Shuang , Zhang Jiarui , Tu Jianwei
Published: June 2022

Macro fiber composite (MFC), which are new ultrathin piezoelectric smart materials, are mostly applied in the fields of shell structure deformation and vibration control. Among others, the application of embedded MFCs in sandwich structures has received wide attention. Currently, its actuating force formula is primarily acquired based on the Bernoulli–Euler Model, which does not consider the shear lag effect and actuating force of MFC ends. To study the actuating performance of an MFC in a sandwich structure, according to its action characteristics, the MFC is divided into upper and lower actuating units without any interaction between to two under the condition of plane strain, and the shear lag effect is considered between the units and the top and bottom of the sandwich structure. The actuating force of the MFC ends is obtained by considering its influence on the bending deformation of the sandwich structure, which deduces the actuating force formula of the embedded MFC. In contrast to ANSYS piezoelectric simulation, the distribution of the MFC interior normal stress is similar to the result from ANSYS piezoelectric simulation, and there is a very small deviation between the MFC end and central normal stress and the result from ANSYS piezoelectric simulation. Taking the end deflection of the sandwich structure with an embedded MFC as an example, the actuating force simulation of the MFC considering the shear lag effect is compared with the ANSYS piezoelectric simulation and actuating force simulation based on the Bernoulli–Euler model. The result indicates that the actuating force simulation of the MFC considering the shear lag effect is closer to the ANSYS piezoelectric simulation, which proves the rationality and necessity of considering the shear lag effect and end actuating force of the MFC.
Hardening of Bimetallic Wires from Secondary Materials Used in the Construction of Power Lines
Authors: Volokitina Irina , Vasilyeva Natalia , Fediuk Roman , Kolesnikov Alexandr
Published: June 2022

Copper-sheathed steel wires combine the conductivity of copper and the traction resistance of steel, which makes a bimetallic wire an ideal material for the construction of power lines. Currently, there is a small number of studies devoted to the change in the microstructure of steel-copper wire during its strain. Since steel and copper have different mechanical properties, these metals at the interface can be deformed in different ways. Therefore, the present research is devoted to the study of ECAP-drawing process impacts on the properties of bimetallic steel-copper wire. During the conducted studies, the possibility and efficiency of using the combined strain technology for the formation of ultrafine grained structure and increased strength properties of steel-copper wire have been proved.
Efficiency of Tool Steel Cutting by Water Jet with Recycled Abrasive Materials
Authors: Perec Andrzej , Radomska-Zalas Aleksandra , Fajdek-Bieda Anna , Kawecka Elzbieta
Published: June 2022

High-pressure water jet machining is characterized by wide possibilities of cutting diverse materials together with multi-layer materials with dissimilar properties, accurate cutting complex profiles, as well as conducting them in uncommon conditions, especially in cases of thick materials. An additional advantage of water jet technology is its environmental friendliness. This paper presents tests of the cutting performance of tool steel with the use of an abrasive water jet (AWJ). The state-of-the-art has shown insufficient scientific evidence in AWJ tool steels cutting using recycled abrasive materials. Therefore, the main motivation for this paper was to carry out research from an environment aspect. The reuse of abrasives and the use of recycled materials have immense potential to reduce processing costs while remaining environmentally friendly. The RSM method was used for modeling and optimization. A response surface design (RSM) is a package of an advanced design-of-experiment (DOE) approaches that support better understanding and optimize response, exploring the relationships between several explanatory variables and one or more response variables. Based on this research, feed rate is the key factor influencing the depth of cut, while the water nozzle diameter has a secondary effect, and the concentration of abrasive has the least influence on the depth of cut. High level of variance (the percentage of variability in the reaction that is interpreted by the formula) confirms that the models fit well to the investigational data.
Robust Tracking Control for Non-Zero-Sum Games of Continuous-Time Uncertain Nonlinear Systems
Authors: Qin Chunbin , Shang Ziyang , Zhang Zhongwei , Zhang Dehua , Zhang Jishi
Published: June 2022

In this paper, a new adaptive critic design is proposed to approximate the online Nash equilibrium solution for the robust trajectory tracking control of non-zero-sum (NZS) games for continuous-time uncertain nonlinear systems. First, the augmented system was constructed by combining the tracking error and the reference trajectory. By modifying the cost function, the robust tracking control problem was transformed into an optimal tracking control problem. Based on adaptive dynamic programming (ADP), a single critic neural network (NN) was applied for each player to solve the coupled Hamilton–Jacobi–Bellman (HJB) equations approximately, and the obtained control laws were regarded as the feedback Nash equilibrium. Two additional terms were introduced in the weight update law of each critic NN, which strengthened the weight update process and eliminated the strict requirements for the initial stability control policy. More importantly, in theory, through the Lyapunov theory, the stability of the closed-loop system was guaranteed, and the robust tracking performance was analyzed. Finally, the effectiveness of the proposed scheme was verified by two examples.
A New 12-Lead ECG Signals Fusion Method Using Evolutionary CNN Trees for Arrhythmia Detection
Authors: Meqdad Maytham N. , Abdali-Mohammadi Fardin , Kadry Seifedine
Published: June 2022

The 12 leads of electrocardiogram (ECG) signals show the heart activities from different angles of coronal and axial planes; hence, the signals of these 12 leads have functional dependence on each other. This paper proposes a novel method for fusing the data of 12-lead ECG signals to diagnose heart problems. In the first phase of the proposed method, the time-frequency transform is employed to fuse the functional data of leads and extract the frequency data of ECG signals in 12 leads. After that, their dependence is evaluated through the correlation analysis. In the second phase, a structural learning method is adopted to extract the structural data from these 12 leads. Moreover, deep convolutional neural network (CNN) models are coded in this phase through genetic programming. These trees are responsible for learning deep structural features from functional data extracted from 12 leads. These trees are upgraded through the execution of the genetic programming (GP) algorithm to extract the optimal features. These two phases are used together to fuse the leads of ECG signals to diagnose various heart problems. According to the test results on ChapmanECG, including the signals of 10,646 patients, the proposed method enjoys the mean accuracy of 97.60% in the diagnosis of various types of arrhythmias in the Chapman dataset. It also outperformed the state-of-the-art methods.
Early Use of ECMO for Refractory Kounis Syndrome Concealed by General Anesthesia—A Case Report
Authors: Yu Ho Kyung , Park Miyeong , Lee Soo Hee , Woo Jung-Woo , Kang Dong-Hoon , Byun Joung Hun , Ok Seong-Ho
Published: June 2022

A 46-year-old woman demonstrated refractory Kounis syndrome (KS) after induction of anesthesia. Despite conventional management of anaphylaxis and advanced cardiac life support, her cardiovascular function continued to deteriorate until she had a cardiac arrest, and after extracorporeal membrane oxygenation (ECMO) therapy, electrical cardiac activity reappeared. A large number of patients with KS—“allergic angina syndrome”—has been known to recover well with vasodilators; however, this patient showed antibiotics-induced refractory KS during general anesthesia. Severe bronchospasms with desaturation appeared as initial anaphylactic features; however, these did not respond to conventional treatment for anaphylaxis. Patient’s hemodynamic signs eventually worsened, leading to cardiac arrest despite ephedrine administration and chest compressions. During cardiopulmonary cerebral resuscitation, the central line was secured, and epinephrine, atropine, as well as sodium bicarbonate were administered repeatedly; nevertheless, cardiac arrest was sustained. After initiation of veno-arterial ECMO, atrial fibrillation was observed, which was later converted to sinus tachycardia by electrical cardioversions and amiodarone. Coronary angiography was performed before the patient was admitted to the intensive care unit; there were no indications of an impending cardiac arrest. The patient was discharged uneventfully owing to early use of ECMO despite the emergence of KS symptoms that were initially masked by anesthesia but later worsened abruptly.
Extended Stress–Strain Characterization of Automotive Steels at Dynamic Rates
Authors: Mirone Giuseppe , Barbagallo Raffaele , Tedesco Michele Maria , De Caro Daniele , Ferrea Matteo
Published: June 2022

Demanding structural applications require a detailed knowledge of the materials response up to the very late stages before failure. Ductile high-strength steels may undergo pronounced necking over the majority of their straining life; this makes a reliable stress–strain characterization difficult, especially at dynamic rates, because the self-heating from fast adiabatic dissipation may promote thermal effects interplaying with the strain rate effects. Further complications arise in deriving the postnecking flow curves when the material is a metal sheet due to geometrical issues intrinsic in the prismatic flat shape of the specimens. This paper focuses on the experimental derivation of the flow curves of DP1000 and MS1700 steels at strain rates ranging from 1 to 500/s. In addition, the moderately high temperatures achieved due to the self-heating at dynamic rates are imposed at static rates for separately investigating thermal and dynamic effects. Digital Image Correlation (DIC) and pixel counting optical techniques are used together with postprocessing procedures based on standard criteria and on physical considerations proposed by the authors. The resulting hardening curves are compared to each other and the advantages of the proposed method are discussed.
Preclinical Pharmacokinetics and Bioavailability of Oxypeucedanin in Rats after Single Intravenous and Oral Administration
Authors: Zheng Ming-Cong , Tang Wen-Ting , Yu Lu-Lu , Qian Xun-Jia , Ren Jie , Li Jie-Jia , Rong Wei-Wei , Li Jun-Xu , Zhu Qing
Published: June 2022

Oxypeucedanin, a furanocoumarin extracted from many traditional Chinese herbal medicines, has a variety of pharmacological effects. However, the independent pharmacokinetic characteristics and bioavailability of this compound remains elusive. In this study, a rapid, sensitive, and selective method using ultra-high performance liquid chromatography–tandem mass spectrometry (UPLC/MS/MS) was developed for evaluating the intravenous and oral pharmacokinetics of oxypeucedanin. After intravenous administration of oxypeucedanin (2.5, 5, and 10 mg/kg), and intragastric administration of oxypeucedanin (20 mg/kg), blood samples were collected periodically from the tail vein. The plasma concentration-time curves were plotted, and the pharmacokinetic parameters were calculated using a non-compartmental model analysis. After intravenous administration of oxypeucedanin (single dosing at 2.5, 5, and 10 mg/kg) to rats, the pharmacokinetics fit the linear kinetics characteristics, which showed that some parameters including average elimination half-life (T1/2Z of 0.61~0.66 h), mean residence time (MRT of 0.62~0.80 h), apparent volume of distribution (VZ of 4.98~7.50 L/kg), and systemic clearance (CLZ of 5.64~8.55 L/kg/h) are dose-independent and the area under concentration-time curve (AUC) increased in a dose-proportional manner. Single oral administration of oxypeucedanin (20 mg/kg) showed poor and slow absorption with the mean time to reach the peak concentration (Tmax) of 3.38 h, MRT of 5.86 h, T1/2Z of 2.94 h, and a mean absolute bioavailability of 10.26% in rats. These results provide critical information for a better understanding of the pharmacological effect of oxypeucedanin, which will facilitate its research and development.
Chemical Characterization and Bioactivity of Commercial Essential Oils and Hydrolates Obtained from Portuguese Forest Logging and Thinning
Authors: Ruas Ana , Graça Angelica , Marto Joana , Gonçalves Lídia , Oliveira Ana , da Silva Alexandra Nogueira , Pimentel Madalena , Moura Artur Mendes , Serra Ana Teresa , Figueiredo Ana Cristina , Ribeiro Helena M.
Published: June 2022

Essential oils (EOs) and hydrolates (Hds) are natural sources of biologically active ingredients with broad applications in the cosmetic industry. In this study, nationally produced (mainland Portugal and Azores archipelago) EOs (11) and Hds (7) obtained from forest logging and thinning of Eucalyptus globulus, Pinus pinaster, Pinus pinea and Cryptomeria japonica, were chemically evaluated, and their bioactivity and sensorial properties were assessed. EOs and Hd volatiles (HdVs) were analyzed by GC-FID and GC-MS. 1,8-Cineole was dominant in E. globulus EOs and HdVs, and α- and β-pinene in P. pinaster EOs. Limonene and α-pinene led in P. pinea and C. japonica EOs, respectively. P. pinaster and C. japonica HVs were dominated by α-terpineol and terpinen-4-ol, respectively. The antioxidant activity was determined by DPPH, ORAC and ROS. C. japonica EO showed the highest antioxidant activity, whereas one of the E. globulus EOs showed the lowest. Antimicrobial activity results revealed different levels of efficacy for Eucalyptus and Pinus EOs while C. japonica EO showed no antimicrobial activity against the selected strains. The perception and applicability of emulsions with 0.5% of EOs were evaluated through an in vivo sensory study. C. japonica emulsion, which has a fresh and earthy odour, was chosen as the most pleasant fragrance (60%), followed by P. pinea emulsion (53%). In summary, some of the studied EOs and Hds showed antioxidant and antimicrobial activities and they are possible candidates to address the consumers demand for more sustainable and responsibly sourced ingredients.
Molecular Modeling in Anion Exchange Membrane Research: A Brief Review of Recent Applications
Authors: Karibayev Mirat , Kalybekkyzy Sandugash , Wang Yanwei , Mentbayeva Almagul
Published: June 2022

Anion Exchange Membrane (AEM) fuel cells have attracted growing interest, due to their encouraging advantages, including high power density and relatively low cost. AEM is a polymer matrix, which conducts hydroxide (OH−) ions, prevents physical contact of electrodes, and has positively charged head groups (mainly quaternary ammonium (QA) groups), covalently bound to the polymer backbone. The chemical instability of the quaternary ammonium (QA)-based head groups, at alkaline pH and elevated temperature, is a significant threshold in AEMFC technology. This review work aims to introduce recent studies on the chemical stability of various QA-based head groups and transportation of OH− ions in AEMFC, via modeling and simulation techniques, at different scales. It starts by introducing the fundamental theories behind AEM-based fuel-cell technology. In the main body of this review, we present selected computational studies that deal with the effects of various parameters on AEMs, via a variety of multi-length and multi-time-scale modeling and simulation methods. Such methods include electronic structure calculations via the quantum Density Functional Theory (DFT), ab initio, classical all-atom Molecular Dynamics (MD) simulations, and coarse-grained MD simulations. The explored processing and structural parameters include temperature, hydration levels, several QA-based head groups, various types of QA-based head groups and backbones, etc. Nowadays, many methods and software packages for molecular and materials modeling are available. Applications of such methods may help to understand the transportation mechanisms of OH− ions, the chemical stability of functional head groups, and many other relevant properties, leading to a performance-based molecular and structure design as well as, ultimately, improved AEM-based fuel cell performances. This contribution aims to introduce those molecular modeling methods and their recent applications to the AEM-based fuel cells research community.
Synthesis of Cyclic Fragrances via Transformations of Alkenes, Alkynes and Enynes: Strategies and Recent Progress
Authors: Lin Zhigeng , Huang Baoying , Ouyang Lufeng , Zheng Liyao
Published: June 2022

With increasing demand for customized commodities and the greater insight and understanding of olfaction, the synthesis of fragrances with diverse structures and odor characters has become a core task. Recent progress in organic synthesis and catalysis enables the rapid construction of carbocycles and heterocycles from readily available unsaturated molecular building blocks, with increased selectivity, atom economy, sustainability and product diversity. In this review, synthetic methods for creating cyclic fragrances, including both natural and synthetic ones, will be discussed, with a focus on the key transformations of alkenes, alkynes, dienes and enynes. Several strategies will be discussed, including cycloaddition, catalytic cyclization, ring-closing metathesis, intramolecular addition, and rearrangement reactions. Representative examples and the featured olfactory investigations will be highlighted, along with some perspectives on future developments in this area.