bluuebunny/crossref_metadata_2025 huggingface dataset:
Prediction of the minimum effective size of a population viable in the long term
Authors: Pérez-Pereira Noelia , Wang Jinliang , Quesada Humberto , Caballero Armando
Published: May 2022

The establishment of the minimum size for a viable population (MVP) has been used as a guidance in conservation practice to determine the extinction risks of populations and species. A consensus MVP rule of 50/500 individuals has been attained, according to which a minimum effective population size of Ne = 50 is needed to avoid extinction due to inbreeding depression in the short term, and of Ne = 500 to survive in the long term. However, the large inbreeding loads (B) usually found in nature, as well as the consideration of selection affecting genetic diversity, have led to suggest that those numbers should be doubled (100/1000). However, none of these modified rules have considered the consequences of purging of deleterious mutations. In a previous simulation study, the reduction of B by the action of purging pointed towards a MVP intermediate between the two previous rules for short term survival. Here, we focused on the consequences of purging in the establishment of MVPs for long term survival. We performed computer simulations of populations under the action of purging, drift, new mutation, and environmental effects on fitness to investigate the extinction times and the loss of genetic diversity. Our results indicate that purging can reduce the MVP needed for a population to persist in the long term, with estimates close to Ne = 500 for species with moderately large reproductive rates. However, MVP values appear to be of at least Ne = 1000 when the species´ reproductive rates are low.
Bromhexine, for post exposure COVID-19 prophylaxis: A Randomized, Double-Blind, Placebo Control Trial
Authors: Tolouian Ramin , Moradi Omid , Mulla Zuber D. , Ziaie Shadi , Haghighi Mehrdad , Esmaily Hadi , Amini Hossein , Hassanpour Rezvan , Pourheidar Elham , Kouchek Mehran , Manafi-Rasi Alireza , Sali Shahnaz , Abolghasemi Sara , Tehrani Shabnam , Tolouian Audrey C. , Zali Alireza , Sistanizad Mohammad
Published: May 2022

Purpose
Limited number of medications are available for the post-exposure prophylaxis of COVID-19 infection. Whether bromhexine can prevent or mitigate symptomatic infection after virus exposure is undetermined.
Methods
A multi-center randomized; double-blind, placebo-controlled clinical trial was conducted. The 372 adults (≥ 18 years) who had close contact within 4 days with a household member with confirmed COVID-19 were randomly assigned to receive bromhexine (n = 187) or placebo (n = 185) three times a day for two weeks. The primary outcome was the incidence of symptomatic COVID-19. Secondary outcomes included the incidence of hospitalization or death, the incidence of confirmed COVID-19 detection by PCR in symptomatic patients and presence of adverse drug reactions.
Results
The incidence of symptomatic COVID-19 was significantly lower in individuals who received bromhexine than in those who received the placebo (16 [8.6%] vs 34 [18.4%], relative risk = 0.47, p = 0.005). PCR-confirmation was reported in 13 (7.0%) and 26 (14.1%) of the individuals in the bromhexine and placebo groups, respectively (p = 0.025), with a relative risk reduction of 50%. The hospitalization rate, death and medication side effects did not vary significantly between the bromhexine or placebo arms.
Conclusion
Bromhexine is an effective, non-invasive, and affordable agent with a low side-effect profile to prevent symptomatic COVID-19. Early use of bromhexine potentially provides another layer of protection and hence it can play a prominent role in ending the pandemic especially given the emergence of new variants and the vaccination challenges faced by developing countries.
P2X4R/p38 signaling pathway in the spinal cord contribute to hyperalgesia in diabetic neuropathic pain
Authors: Qu Siying , Wang Hanzhi , Hu Qunqi , Ma Yiqi , Kang Yurong , Ma Liqian , Li Xiang , Chen Luhang , Liu Boyu , Shao Xiaomei , Liu Boyi , Du Junying , Liang Yi , Zhao Hongli , Jiang Yongliang , Fang Jianqiao , He Xiaofen
Published: May 2022

Management of diabetic neuropathic pain (DNP), a prevalent, refractory diabetic complication, remains a challenge. Previous research evidences have implicated microglia P2X4 receptor (P2X4R) in occurrence and development of DNP. To date, however, the specific mechanism of microglia P2X4R action in DNP needs to be further explored. We elucidated the role and underlying mechanism of microglia P2X4R in DNP. The DNP rat model was established by injection of streptozotocin (STZ). DNP rats developed thermal hyperalgesia from day 14. Western blot and immunofluorescence analyse revealed that microglia, P2X4R, p-p38 mitogen-activated protein kinase (p-p38 MAPK), and downstream targets brain-derived neurotrophic factor (BDNF), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β) were upregulated in the spinal cord. In addition, a P2X4R antagonist 5-BDBD and a microglia inhibitor minocycline (mino) not only alleviated DNP, but also suppressed P2X4R, microglia, p-p38 MAPK, BDNF, TNF-α and IL-1β levels in the spinal cord. Based on these findings, it was evident that central pain sensitization in DNP occurs via the microglia P2X4R/p38 signaling pathway, while p-p38 MAPK activates microglia to release BDNF, TNF-α and IL-1β in spinal cords. These results demonstrate that P2X4R/p38 signaling pathway in microglia residing in the spinal cord contribute to the establishment and long term maintenance of DNP and that these represent potential targets for pain therapy.
Relationship between increased systemic immune-inflammation index and coronary slow flow phenomenon.
Authors: Dai Xin-tong , Kong Tian-zhong , Zhang Xiao-jiao , Luan Bo , Wang Yong , Hou Ai-jie
Published: May 2022

Background: Systemic immune-inflammation index (SII, platelet × neutrophil/lymphocyte ratio), a new marker of inflammation, is associated with adverse cardiovascular events, but its relationship with coronary slow flow phenomenon (CSFP) is unclear. Therefore, we aimed to investigate the relationship between SII and CSFP. Methods: We enrolled consecutive patients who presented with chest pain, with normal/near-normal coronary angiography findings (n=89 as CSFP group; n=167 as control group). The baseline characteristics, laboratory parameters and angiographic characteristics of the two groups were compared. Results: SII levels were significantly higher in the CSFP group than in the control group (409.7 ± 17.7 vs. 396.7 ± 12.7, p < 0.001). A significant positive correlation between SII and the mean thrombolysis in myocardial infarction frame count (mTFC) was found (r = 0.624, p <0.001). SII increased with the number of coronary arteries involved in CSFP. In multivariate logistic regression analysis, SII/10 was an independent predictor of CSFP (odds ratio: 1.739, P <0.001). In addition, the SII level > 404.29 was a predictor of CSFP with 67.4% sensitivity and 71.9% specificity. Conclusions: SII can predict the occurrence of CSFP.
Recommended System Optimization in Social Networks based on Cooperative Filter with Deep MVR Algorithm
Authors: Gao Qiang
Published: May 2022

Today, social networks have become very popular due to their high usage in communicating with each other. But this popularity requires the development of backend to communicate with each other. Hence, a topic called identifying users is created by making recommendations or propositional systems, and so on, link prediction. The most important issue is the new users' social networks, so that they can offer suggestions. In this research, we tried to provide a system of recommendations for introducing new users to previous users and vice versa based on the principles of machine learning. The proposed method is that the data is entered into the program and then the keywords are extracted from them. Then a sampling between the data is performed based on the Pearson and Cronbach method. In the process of extraction operations along with diminishing dimensions, selection and finally extraction of the best features is done using the cooperative filter which named here based on deep learning- Modified Vector Rotational (MVR) algorithm and its operators. In the following, due to the lack of probabilistic and statistical training of the Deep and Reinforcement Learning with random structure that is used to select users and also to offer users with respect to the tastes of the extracted, there is an optimization algorithm for MVR consider the best features with training. In the following, a series of evaluation criteria have been used to ensure the proposed approach, indicating the appropriate results of the proposed method.
Exercise-induced pulmonary hypertension in hypertrophic cardiomyopathy: A combined cardiopulmonary exercise test –echocardiographic study
Authors: Re Federica , Halasz Geza , Moroni Francesco , Beltrami Matteo , Baratta Pasquale , Avella Andrea , Zachara Elisabetta , Olivotto Iacopo
Published: May 2022

Purpose: Pulmonary arterial hypertension (PAH), documented in a significant portion of hypertrophic cardiomyopathy (HCM) patients, has been shown to adversely impact prognosis. In most HCM patients congestive symptoms are consistently elicited by exercise, thus suggesting the need for a provocative test to assess cardiac hemodynamics during effort. Combining cardiopulmonary exercise test (CPET) with echocardiography, we aimed to evaluate the presence of exercise induced pulmonary arterial hypertension (EiPAH), its role in functional limitation and its prognostic significance in a cohort of patients with obstructive and non-obstructive HCM.Methods: study population included 182 HCM patients evaluated combining CPET and stress echocardiography. Left-ventricular outflow tract (LVOT) velocities, trans-tricuspid gradient, and cardiopulmonary variables were continuously measured. Results: Thirty-seven patients (20%) developed EiPAH, defined as systolic pulmonary arterial pressure (sPAP)>40 mmHg during exercise. EiPAH was associated with lower exercise performance, larger left atrial volumes, higher LVOT gradient and higher VE/VCO2 slope. At multivariable analysis baseline sPAP (p<0.0001) and baseline LVOT obstruction (p=0.028) were significantly associated with EiPAH. Kaplan-Meier curve analysis showed EiPAH was a significant predictor of HCM-related morbidity (Hazard Ratio: 6.21, 95% CI 1.47-26.19; p=0.05; 4.21 ,95% CI 1.94-9.12; p<0.001 for the primary and the secondary endpoint respectively). Conclusion: EiPAH was present in about one fifth of HCM patients without evidence of elevated pulmonary pressures at rest and was associated with adverse clinical outcome. Diagnosing EiPAH by exercise echocardiography/CPET may help physicians to detect early stage of PAH thus allowing a closer clinical monitoring and individualized therapies
Special functions and multi-stability of the Jensen type random operator equation in C*-algebras via fixed point
Authors: Aderyani Safoura Rezaei , Saadati Reza , Li Chenkuan , Rassias Themistocles M. , Park Choonkil
Published: May 2022

See manuscript PDF for complete Abstract:In this paper, we apply some special functions to introduce a new class of control functions which help us define the concept of multi-stability. Further, we investigate the multi-stability of homomorphisms in C*-algebras and Lie C*-algebras and multi-stability of derivations in C*-algebras and Lie C*-algebras for the following random operator equation via fixed point methods:\[ \mu f(\eth, \frac{x+y}{2}) + \mu f(\eth,\frac{x-y}{2}) = f(\eth ,\mu x) .\]In particular for $\mu = 1$, the above equation turns out to be Jensen's random operator equation.
Detection and Evaluation of Breed-specific SNPs and Minor allele frequency in Ethiopian Indigenous and European Beef Cattle Breeds
Authors: Mengistie Dejenie , Edea Zewdu , Tesema Tesfaye sisay , Dejene Genet , Jemal Jeilu , Dessie Tadelle , Kim Kwan Suk , Samuel Behailu , Dadi Hailu
Published: May 2022

Introduction
Understanding the genetic foundation of locally adapted indigenous cattle breeds is critical information for developing appropriate genetic improvement and conservation methods and initiatives.
Methods
To investigate breed-specific SNPs, and minor allele frequency in three Ethiopian cattle breeds Begait, (n = 40), Boran (n = 40), and Fogera (n = 43) were genotyped with a high-density 80K SNP array. Three European beef cattle breeds (Angus, n = 42), Hereford (n = 35), and Charolais (n = 37) were also used for comparison. The SNP markers were screened for a call rate of ≥ 90%, a minor allele frequency (MAF) of > 0.01, and a sample call rate of > 90%.
Results
The average minor allele frequency was 0.19 ± 0.17, 0.20 ± 0.17, 0.21 ± 0.17, 0.31 ± 0.13, 0.32 ± 0.12, 0.32 ± 0.13 for Angus, Herford, Charolais, Boran, Fogera, and Begait cattle, respectively. Minor allele frequency significance difference was observed between Ethiopian indigenous and European beef cattle breeds. Across the Ethiopian and European cattle breeds, a common variant minor allele frequency (≥ 0.10 and ≤ 0.5) accounted for an overall estimated 94% and 62%, of the SNPs respectively. A total of 7759 and 48 SNPs were identified as breed-specific in the Ethiopian cattle breeds and European beef cattle respectively. These specific SNPs resided with 3364 genes for Ethiopian cattle breeds and 17 genes for European beef cattle breeds. According to Gene Ontology analysis, interestingly important biological processes and pathways related to tropical adaptation were detected in Ethiopian cattle breeds.
Conclusions
The higher minor allele frequency and breed-specific SNPs detected in Ethiopian indigenous breeds show the presence of high genetic variability. This genetic variation in Ethiopian cattle breeds is used as a potential source for future breeding programs.
Embryonic nutritional hyperglycemia decreases cell proliferation in the zebrafish retina
Authors: Hernández-Núñez Ismael , Vivero-Lopez Maria , Quelle-Regaldie Ana , DeGrip Willem J. , Sánchez Laura , Concheiro Angel , Alvarez-Lorenzo Carmen , Candal Eva , Barreiro-Iglesias Antón
Published: May 2022

Diabetic retinopathy (DR) is one of the leading causes of blindness in the world. While there is a major focus on the study of juvenile/adult DR, the effects of hyperglycemia during early retinal development are less well studied. Recent works in embryonic zebrafish models of nutritional hyperglycemia revealed that hyperglycemia leads to decreased cell numbers of mature retinal cell types, which has been related to a modest increase in apoptotic cell death and altered cell differentiation (Singh et al. 2019; Titialii-Torres and Morris 2022). However, how embryonic hyperglycemia impacts cell proliferation in developing retinas remains still unknown. Here, we exposed zebrafish embryos to 50 mM glucose from 10 hours postfertilization (hpf) to 5 days postfertilization (dpf). First, we confirmed that hyperglycemia increases apoptotic death and decreases the rod and Müller glia population in the retina of 5 dpf zebrafish. Interestingly, the increase in cell death was mainly observed in the ciliary marginal zone (CMZ), where most of the proliferating cells are located. To analyze the impact of hyperglycemia in cell proliferation, mitotic activity was first quantified using pH3 immunolabeling, which revealed a significant decrease in mitotic cells in the retina (mainly in the CMZ) at 5 dpf. A significant decrease in cell proliferation in the outer nuclear and ganglion cell layers of the central retina in hyperglycemic animals was also detected using the proliferation marker PCNA. Overall, our results show that nutritional hyperglycemia decreases cellular proliferation in the developing retina, which could contribute significantly to the decline in the number of mature retinal cells.
Distributed Identification of Central Nodes with Less Communication
Authors: Masakuna Jordan F. , Kafunda Pierre K.
Published: May 2022

This paper is concerned with distributed detection of central nodes in complex networks using closeness centrality. Closeness centrality plays an essential role in network analysis. Evaluating closeness centrality exactly requires complete knowledge of the network; for large networks, this may be inefficient, so closeness centrality should be approximated. Distributed tasks such as leader election can make effective use of centrality information for highly central nodes, but complete network information is not locally available. This paper refines a distributed centrality computation algorithm by You et al. [24] by pruning nodes which are almost certainly not most central. For example, in a large network, leave nodes can not play a central role. This leads to a reduction in the number of messages exchanged to determine the centrality of the remaining nodes. Our results show that our approach reduces the number of messages for networks which contain many prunable nodes. Our results also show that reducing the number of messages may have a positive impact on running time and memory size.
Gastric lymphoma and spontaneous remission associated with co-infection of COVID-19 and undefined typical bacterial agent.
Authors: Kurmanova Gaukhar , Bossatbekov Yerkebulan , Alimanova Zhanna , Tankayeva Sholpan , Bugibaeva Akbota , Sarawata Abhishek , Singh Kajal , Abbas Fuza Adhur Manhuvalappa , Singh Neetu
Published: May 2022

Background: Article shows a clinical experience with the patient with primary gastric lymphoma, and it shows reduction of the lymphoma condition into the spontaneous remission, after community-acquired pneumonia, which was associated with co-infection of COVID-19 and undefined typical bacterial agent. The positive response happened on the standard antibacterial and basic symptomatically treatment. Case presentation: A 65-years-old woman was admitted by ambulance to the emergency department with sever condition. In time of hospitalization the patient has been diagnosed with primary gastric lymphoma, ulcer form, with signs of ongoing capillary bleeding, chronic bronchitis, diabetes militias type 2 complicated hypoglycaemic condition associated with metformin, thrombocytopenic syndrome, normochromic anaemia. The condition was confirmed by laboratory and instrumental investigation. Conclusion: Article shows extremely positive response up to disappearing of ulcer, which was associated with lymphoproliferative disorder. The condition of that was associated with highly cytokines production with anti-tumor effect.
The Effect of a Randomised Controlled Lifestyle Intervention on Weight Loss and Plasma Proneurotensin
Authors: Fawad Ayesha , Struck Joachim , Larsson Sara Lönn , Bergmann Andreas , Melander Olle , Bennet Louise
Published: May 2022

Aims: Proneurotensin is a strong predictor of cardiometabolic disease, however, the effect of lifestyle change on proneurotensin has not been investigated. Middle Eastern (ME) immigrants represent the largest and fastest growing minority population in Europe and are a high-risk population for obesity and type 2 diabetes. In this randomised controlled lifestyle intervention (RCT) addressing ME immigrants to Sweden where weight-loss was previously studied as the main outcome, as a secondary analysis we aimed to study change in proneurotensin during follow-up and if baseline proneurotensin predicted weight loss. Methods: Immigrants from the Middle East at high risk for type 2 diabetes were invited to participate in this RCT adapted lifestyle intervention of four months’ duration. The intervention group (N=48) received a culturally adapted lifestyle intervention comprising seven group sessions and a cooking class addressing healthier diet and increased physical activity. The control group (N=44) received treatment as usual with information to improve lifestyle habits on their own. Data assessed using mixed effects regression.Outcomes: Primary outcome; change in proneurotensin. Secondary outcome; change in BMI in relation to baseline plasma concentration of proneurotensin. Results: During the four months follow up, weight was significantly reduced in the intervention (-2.5 kg) compared to the control group (0.8 kg) (β -0.12, 95% CI -0.24 to -0.01, P=0.028). Proneurotensin increased to a significantly greater extent in the intervention compared to the control group during follow up (28.2 vs 3.5 pmol/L) (β 11.4; 4.8 to 18.02, P<0.001). Change over time in BMI was associated with baseline proneurotensin (β 0.02; 0.01 to 0.04, P=0.041).Conclusion: In consistence with data from surgical weight loss, this RCT paradoxically shows increased levels of proneurotensin during a multifactorial lifestyle intervention resulting in weight loss. Long term studies of proneurotensin following weight loss are needed.
Hansische Umschau 2019
Authors: Jörn Nils
Published: May 2022

Vollständiger Rezensionsteil
The relationship between physical activity and polypharmacy with Ikigai in a population
Authors: Belice Tahir , Yildirim Nejla Ozkan , Gursoy Utkucan , Güleryüz Okan , Demir Ismail , Yüksel Arif
Published: May 2022

The aim: The Japanese word “ikigai” indicates “something to live for” and “having a purpose in life”. Ikigai or well-being, has been associated with many positive outcomes in the physical and mental health of elderly people. In this study, the relationship between ikigai and level of physical activity and polypharmacy was examined in a Turkish population.

Material and methods: Both telephonic interviews and face-to-face interviews were conducted with 307 participants (59.2 % women) who completed the Ikigai-9 Turkey Scale and provided demographic information.

Results: Correlations between groups (polypharmacy vs. non-polypharmacy) were analyzed with an independent t-test and analysis of variance. The means of the ikigai scores were statistically significant in the polypharmacy (24.04±8.72) and non-polypharmacy 32.64±7.53) groups (p<0.05). The number of drugs used was negatively correlated with duration of exercise per week (1.32±1.82, correlation coefficient = 0.538, p<0.05).

Conclusions: The level of ikigai was negatively correlated with polypharmacy and positively correlated with duration of physical activity. An individual’s ikigai should be assessed by healthcare providers to maximize positive outcomes later in life
Internet television in Bangladesh: past and present
Authors: Kabil Khan Abdul , Shnaider Anna
Published: May 2022

The development of digital technologies has radically changed the direction of the development of modern media. Professional producers of information – newspapers, radio broadcasting, and television – entered the Internet no more than fifteen years ago. The Internet is used by almost all types of media in the world as an additional channel for the transmission and distribution of content. Many media experts see a great future in the Internet media market. In Bangladesh, home to 160 million people, Internet media are already popular and growing rapidly.

Internet TV began to function at the beginning of the 21st century. It was created specifically for broadcasting on the network, which requires a high level of technical equipment from both the producer and the content provider and the consumer. Therefore, chronologically, television was the last type of media that entered the Internet.

In this report, we analyze the basic features of Internet Television that exists in contemporary Bangladesh and provide an account of the development trends. We analyzed Internet Television broadcasters in Bangladesh, like “ATN Music”, “Popcorn Live”.

This study is based on both primary and secondary sources of qualitative data to understand the ability of Internet TV to provide news, qualitive information, together with the challenges and opportunities of it to work in the ever-changing media landscape.
Structural Health Monitoring Using Sensors with Application of Wavelet Analysis
Authors: Saranya S.
Published: May 2022

Abstract. Structural Health Monitoring (SHM) establishes a damage detection system to maintain safety in the current structure. Owners and maintenance managers are looking for cost-effective and dependable inspection and monitoring solutions to ensure the safety and reliability of capital-intensive assets. A longer overhaul time is envisaged with today's software technology and design codes. The visualization aims to put advanced technology into practice to provide consumers and the government with value-added services. Meanwhile, the wavelet transforms, a signal processing technique based on a windowing approach using enlarged 'scaled' and shifted wavelets, is being applied in various industries. By bypassing many of the restrictions of the Fourier transform (FT), the wavelet transform has proven to be effective in SHM systems. Structures tend to get damaged in situations such as accidental fire, aggregate contraction, salinity exposure, corrosion due to bacterial influence, physical and material damage. Also, structures tend to lose their tensile strength when exposed to long-term factors such as moisture, heat, rains, storms, etc. Structural Health Management plays a vital role here to monitor the health conditions of structures to prevent any loss. To stand up for this need, it is imminent to provide a safe structure for people to ply through. The proposed methodology shows a clear picture of how to assess any structure condition at any time and gives a clear view of its current stature on whether it is damaged. Hence in this article, the behavior of the structure is assessed using wavelet transformation. The hardware configurations, including the MSP430FR6989 microcontroller with TDC1000-TDC7200EVM, are embedded with the aggregate, making it smart enough to detect the defects through the software interpretation with a signal processing toolbox of MATLAB coding.
Carbon-Based Nanomaterial Embedded Self-Sensing Cement Composite for Structural Health Monitoring of Concrete Beams - A Extensive Review
Authors: Dinesh A.
Published: May 2022

Abstract. Structural health monitoring has proven to be a dependable source for ensuring the integrity of the structure. It also aids in detecting and estimating the progression of cracks and the loss of structural performance. The most compelling components in the structural health monitoring system are sensing material and sensor technology. In health monitoring systems, fiber optic sensors, strain gauges, temperature sensors, shape memory alloys, and other types of sensors are commonly used. Even though the sensors bring monetary value to the system, they have some apparent drawbacks. As a result, self-sensing cement composite was established as a sensor alternative with better endurance and compatibility than sensors. Carbon nanotubes, nanofibers, graphene nanoplates, and graphene oxide are carbon-based nanomaterials with unique mechanical and electrical properties. As a result, this review comprises a complete assessment of the fresh, mechanical, and electrical properties of self-sensing cement composite developed using carbon-based nanoparticles. The research also focuses on the self-monitoring performance of cement composite in concrete beams, both bulk and embedded, by graphing the deviation of fractional change in resistivity with strain. The network channel development of carbon-based nanomaterials in cement composites and their characterization acquired using scanning electron microscopy (SEM), and X-Ray diffraction spectroscopy (XRD) research are also comprehensively discussed. According to the study, increasing carbon-based embedment decreased the relative slump and flowability while increasing the composite's compressive, split tensile, flexural, and post-peak performance. Also, the amount of carbon in the carbon-based nanomaterial directly relates to the composite's conductivity. As a result, the development of piezoresistive and sensing capabilities in carbon-based self-sensing cement composites not only improves mechanical and conductive properties but also serves as a sensor in structural health monitoring of flexural members.
A Constructive Analysis on Topology Optimization of Structural Beam Element Using Different Support Condition
Authors: Jensika Rani J.
Published: May 2022

Abstract. Topology Optimization (TO) is the method used for maximizing the performance of the system by optimizing material arrangement inside an appropriate topology design operation, for an appropriate set of loads, boundary restraints, and constraints. This helps in the reduction of the materials which in turn reduces the cost of materials. In the current scenario, the price of the ingredients of the traditional concrete is very high. The implementation of TO gives a good impact on the economy of construction, as the materials are optimally placed in the plane of load distribution as per various loading condition. The Evolutionary Structural optimization (ESO) is used for topology optimization. The main merits of implementing topology optimization are that the cost, as well as the weight of the structural member, becomes more effective. Customarily MATLAB software is used for analysis and designing the member. This method will highly useful for the society and the environment.
Utilizing beacon technology for the development of a smart attendance system
Authors:   Department of Computer Science, Applied College, University of Tabuk, Tabuk, Saudi Arabia, Alrowaily Majed Abdullah
Published: May 2022

Tracking students’ attendance is part of academic cycles, however, academic staff members become overwhelmed by applying traditional methods for recording this. The dominant method of recording attendance is traditional methods such as calling students’ names and passing attendance sheets. These methods raise some concerns such as being time-consuming, spreading Coronavirus by sharing the attendance sheet, and other issues. The introduced and implemented solutions in the literature are rather expensive, time-consuming, lack accuracy, or require a long process to record the attendance. In this project, we aim to investigate the use of Bluetooth Low Energy (BLE) beacons at the main campus of Tabuk University to build a smart attendance system called the UTSA system. This system will help to overcome the raised concerns of applying the traditional methods for recording student attendance. Three interactive HTML prototypes were developed and examined using a heuristic evaluation methodology. The third proposed prototype, the instructor web-based system, was the most pleasing prototype by most evaluators compared to the two prototypes of the mobile app. All of the evaluators agreed that the current attendance system at Tabuk University is time-consuming and vulnerable to human errors during the transference of attendees from the attendance sheets to the online attendance system. The proposed system of this work provides an accurate and affordable method for signing in the students' attendance as it is going to be done using two steps for recording the attendance: Students mobile attendance broadcasting and academic staff verification process using the proposed app. Moreover, no additional equipment needs to be installed to apply the proposed solution as it used the students and the academic staff members mobile phones.
An Intelligent Integration for Medical Information
Retrieve : A Smartphone based Application (Preprint)
Authors: Abd-Allah Esraa Mostafa
Published: May 2022

UNSTRUCTURED

Abstract— Nowadays, smartphones have reached every hand and
every home. As a result, people are making use of the beneficial
mobile applications to make their everyday life easier. This paper
focuses on development of a mobile application (app) to help
providing an effective health care and pharmacy system. Using
this app, people can get numerous benefits like retrieving
medicines information, information about all medicines
alternatives, active ingredients with its concentrations, and
interactions between different medicines. This can help reducing
the threat that two or more medicines are consumed together.
Drug-disease relationships, suggestions on choosing appropriate
tips based on the user's gender, age, and disease history as part of
the community medicine system, and finding the nearest
pharmacies. Optimizing (SEO) as a local search engine in the app
to track search word trends and predict future patterns, as well
as drug details such as its picture, warnings, dosages, etc. This
application will be a helping hand for people or patients who find
it difficult to track their health, providing medical information
through doctors or patients special needs, providing advice and
medicine reminder tips in their everyday life by providing health
care information, especially in the period of the spread of diseases
and the lack of some medicine, as was clear during the spread of
Covid 19.
Retention and bias assessment among an online trial of men who have sex with men in Shandong province, China. (Preprint)
Authors: Wang Lina , Lin Yuxi , Wang Yao , Yan Yu , Jiao Kedi , Li Yijun , Li Chuanxi , Wu Taoyu , Cheng Chunxiao , Ren Ci , Xu Zece , Wang Lin , Kang Dianmin , Liao Meizhen , Ma Wei
Published: May 2022

BACKGROUND

In prospective studies, the rate of loss of follow-up (LTFU) has a significant impact on the validity of the results. Although some studies have explored the influencing factors of retention among men who have sex with men (MSM), most of them are concentrated in a single region and mostly offline research, and there is no more understanding of the predictors retained in online prospective studies of MSM population.

OBJECTIVE

This study aimed to investigate the retention in an online trial of men who have sex with men (MSM) in 10 cities of Shandong province and evaluate the effect of bias on the relationship between exposures and HIV testing.

METHODS

We selected 10 cities in Shandong province as the study area to carry out a randomized controlled trial and followed up for about 12 months. Participants were followed up approximately every three months for a total of four times. Information collected included social demographic characteristics, sexual behavior, HIV testing, etc. Loss to follow-up (LTFU) was defined as the respondents who met the inclusion criteria but had not participated in any follow-up visits after entering the cohort. LTFU and the number of follow-up visits, which were used as the indicators to evaluate the retention of the respondents, were estimated by Cox proportional hazard model and a generalized Poisson regression model, respectively. In addition, the bias was assessed to further explain the impact of LTFU.

RESULTS

We recruited 935 participants in the study, 184 of whom did not participate in any follow-up, and the LTFU rate was 19.68%. The results of multivariate analysis showed that both the LTFU and the number of follow-up visits were closely related to the city and sexual orientation. LTFU and less follow-up visits were common among heterosexual/bisexual participants, and relatively less in homosexual participants. Participants in cities with lower GDP were more likely to be lost and had less follow-up visits than those in cities with higher GDP. Besides, the higher the educational level, the more times to participate in follow-up visits. The results of bias assessment suggested that the bias caused by LTFU underestimated the relationship between cities and HIV testing, but overestimated the relationship between age, sexual orientation disclosure and HIV testing.

CONCLUSIONS

The retention of an online trial among MSM in 10 cities of Shandong province was not ideal and LTFU mainly occurred in the first follow-up. Future strategies should focus on cities with lower GDP, sexual orientation (heterosexual/bisexual) and less educated participants to improve the retention rate of studies. Moreover, bias assessment can be used to evaluate the association of exposure and outcome, which made the interpretation of results more credible.
Ảnh hưởng thời điểm bổ sung thức ăn tổng hợp lên tăng trưởng và tỷ lệ sống của cá chim vây vàng (Trachinotus blochii) giai đoạn
Authors: Lê Quốc Việt , Lý Văn Khánh , Trần Nguyễn Duy Khoa , Trần Ngọc Hải
Published: May 2022

Nghiên cứu được thực hiện nhằm xác định thời gian bổ sung thức ăn tổng hợp thích hợp lên sinh trưởng và đồng thời nâng cao tỷ lệ sống của cá chim vây vàng ở giai đoạn cá hương lên cá giống. Thí nghiệm được bố trí hoàn toàn ngẫu nhiên gồm 4 nghiệm thức với thời điểm bổ sung thức ăn tổng hợp khác nhau (15, 18, 21, 24 ngày tuổi) với 3 lần lặp lại. Cá được bố trí trong bể nhựa có thể tích 100 L/bể, độ mặn 30‰ và mật độ ương 1 con/lít. Cá có khối lượng và chiều dài trung bình ban đầu lần lượt là 0,03 g/con và 9,02 mm/con. Sau 30 ngày ương, không có sự khác biệt về tăng trưởng chiều dài và chiều cao thân giữa các nghiệm thức (DLG và SGRL, DHG và SGRH, p > 0,05), nhưng tăng trưởng khối lượng cá (DWG và SGRW) ở nghiệm thức bổ sung ngày 15-18  tuổi (DAH) cao hơn đáng kể so với 24 DAH  (p < 0,05). Tỷ lệ sống của cá đạt 91,48 -97,41%, nhưng không có sự khác biệt về tỷ lệ sống giữa các nghiệm thức (p > 0,05). Kết quả cho thấy nên bắt đầu cho cá ăn thức ăn công nghiệp từ ngày 15-18 DAH.
Yếu tố huyền thoại trong truyện Việt Nam nửa đầu thế kỉ XX
Authors: Hoàng Thị Thùy Dương
Published: May 2022

Bài viết phân tích các đặc điểm của yếu tố huyền thoại trong truyện Việt Nam nửa đầu thế kỉ XX. Các yếu tố này là kết quả của sự kế thừa kho tàng thần thoại của nhân loại. Yếu tố huyền thoại trong truyện Việt Nam giai đoạn này được phân tích trong bốn phương diện: mô típ  nhân vật, không gian, thời gian. Việc tìm hiểu về các yếu tố này góp phần lí giải đặc điểm của văn học giai đoạn này trong hành trình kế thừa huyền thoại.
Phân tích hiệu quả kinh doanh của doanh nghiệp tỉnh Vĩnh Long
Authors: Trương Thị Thúy Hằng , Võ Thành Danh , Phan Đình Khôi , Huỳnh Việt Khải
Published: May 2022

Thực trạng hoạt động sản xuất kinh doanh, ứng dụng khoa học cộng nghệ và phân tích các yếu tố ảnh hưởng đến hiệu quả kinh doanh của các doanh nghiệp trên địa bàn tỉnh Vĩnh Long được trình bày trong bài viết. Có hai loại dữ liệu được dùng trong phân tích là dữ liệu điều tra sơ cấp với 53 doanh nghiệp được chọn theo phương pháp chọn mẫu ngẫu nhiên và dữ liệu thứ cấp với 1.521 doanh nghiệp được khảo sát năm 2019. Phương pháp phân tích được sử dụng là thống kê mô tả và mô hình hồi quy. Kết quả nghiên cứu cho thấy trong thời gian qua các doanh nghiệp đã thực hiện nhiều hoạt động về khoa học công nghệ, đổi mới sáng tạo và ứng dụng công nghệ thông tin trong sản xuất, kinh doanh, và quản trị doanh nghiệp. Kết quả nghiên cứu cũng chỉ ra rằng vốn chủ sở hữu, tài sản hiện hành, quy mô doanh nghiệp là các yếu tố có ảnh hưởng đến hiệu quả kinh doanh của doanh nghiệp.
Chế tạo hệ cầu cân bằng tích hợp bộ bù sai số định vị cho cảm biến siêu âm và hồng ngoại
Authors: Nguyễn Chí Ngôn , Nguyễn Văn Thọ , Trần Thị Hồng Phượng
Published: May 2022

Hệ cầu cân bằng với thanh và bóng thường được dùng để kiểm nghiệm các giải thuật điều khiển. Do tốc độ di chuyển nhanh của bóng trên thanh trượt nên khi cảm biến lấy mẫu vị trí bóng và truyền dữ liệu về đến máy tính, quả bóng đã di chuyển sang vị trí mới, ảnh hưởng đến chất lượng điều khiển. Nghiên cứu này tập trung thiết kế và chế tạo mô hình cầu cân bằng, định vị quả bóng bằng cảm biến siêu âm và hồng ngoại. Hàm bù sai số cảm biến được áp dụng để khắc phục sai số cảm biến và độ trễ do truyền dữ liệu. Module Arduino UNO R3 được sử dụng để truyền tín hiệu điều khiển từ máy tính xuống mô hình để kiểm soát động cơ và nhận tín hiệu vị trí đo được từ cảm biến để phản hồi cho máy tính. Thực nghiệm với bộ điều khiển RBF-PID và cảm biến hồng ngoại cho thấy đáp ứng của hệ có thời gian tăng đạt 1,5 ± 0,3 giây, thời gian xác lập khoảng 6 ± 1 giây, độ vọt lố khoảng 11 ± 2%, và sai số xác lập là không đáng kể.
Tổng hợp có kiểm soát kích thước các hạt lignin từ bã mía với sự hỗ trợ của thanh siêu âm
Authors: Cao Lưu Ngọc Hạnh , Lương Huỳnh Vủ Thanh , Nguyễn Trọng Tuân , Nguyễn Thị Bích Thuyền , Ngô Trương Ngọc Mai , Nguyễn Thị Mỹ Huyền , Võ Duy Tân
Published: May 2022

Nghiên cứu tập trung tổng hợp các hạt vi cầu lignin từ lignin bã mía thông qua quá trình khâu mạng hóa học với sự hỗ trợ của thiết bị siêu âm dạng thanh. Trong quá trình tổng hợp, nghiên cứu đã dần kiểm soát được kích thước của hạt lignin bằng cách điều chỉnh các thông số như tỷ lệ thể tích giữa dung dịch khâu mạng và dung dịch lignin trong ethanol và tần số siêu âm. Cụ thể, các thông số tối ưu như tỷ lệ thể tích giữa citric acid và dung dịch lignin là 4/100 và tần số siêu âm là 15 kHz. Với các thông số này, vi hạt lignin thu được với đường kính hạt nhỏ nhất ở 187,9 ± 6,7 nm, hình thái hạt cầu hoàn thiện, có ranh giới rõ ràng giữa các hạt và sự phân bố kích thước hạt tương đối đồng đều. Kết quả từ FTIR thể hiện các đỉnh đặc trưng của hạt lignin tổng hợp và độ tinh khiết khá cao. Ngoài ra, nhiệt độ chuyển thủy tinh của hạt lignin ~109ᵒC và nhiệt độ nóng chảy được xác định ~75ᵒC thông qua DSC.
Đánh giá khung pháp lý của nhà nước về tài nguyên nước mặt tại tỉnh Sóc Trăng
Authors: Hà Tấn Linh , Dương Thị Trúc , Nguyễn Hiếu Trung , Đặng Kiều Nhân , Văn Phạm Đăng Trí
Published: May 2022

Nghiên cứu dựa vào nguyên tắc 7 của Tổ chức Hợp tác và Phát triển Kinh tế (OECD) để đánh giá khung pháp lý quản lý tài nguyên nước trên địa bàn tỉnh Sóc Trăng. Số liệu thứ cấp là các văn bản quản lý Nhà nước về phòng, chống xâm nhập mặn được thu thập thông qua cổng thông tin điện tử của Chính phủ, cấp tỉnh và cấp huyện; số liệu sơ cấp được thu thập thông qua phỏng vấn những người am hiểu về tài nguyên nước tại các huyện Kế Sách, Long Phú và Trần Đề từ năm 2019 đến 2021. Công tác phòng, chống xâm nhập mặn (XNM) đã có khung pháp lý quy định nhiệm vụ, quyền hạn của chính phủ, các bộ và chính quyền địa phương về phòng, chống XNM. Ngoài ra, Trung ương và tỉnh đã triển khai toàn diện, chặt chẽ các giải pháp ứng phó với XNM giai đoạn 2019-2021. Tuy nhiên, một số nhiệm vụ của tỉnh về phòng, chống XNM còn hạn chế về các giải pháp công trình không đảm bảo tính khả thi so với thực trạng XNM tại địa phương.
Ảnh hưởng của điều kiện sinh thái đến hoạt tính sinh học của Chè đại (Trichanthera gigantea)
Authors: Nguyễn Trọng Hồng Phúc , Phan Thành Đạt , Nguyễn Thanh Trước , Lâm Vĩ Nhã , Nguyễn Nguyền Trân , Bùi Trần Thảo Nguyên , Nguyễn Thị Yến Lan , Đặng Minh Quân
Published: May 2022

Chè đại (Trichanthera gigantea) là loài có giá trị dinh dưỡng thường được dùng làm thức ăn vật nuôi. Nghiên cứu này khảo sát thành phần hóa học, hiệu quả kháng oxy hóa và kháng khuẩn của chè đại thông qua phương pháp phản ứng so màu, phương pháp trung hòa gốc tự do DPPH và phương pháp khuếch tán giếng thạch. Kết quả cho thấy có 18 hợp chất hóa học trong lá Chè đại gồm amino acid - protein, acid hữu cơ, betalanins, carbohydrate, carotenoid, chất nhầy, coumarin, diterpenes, flavonoid, gum - nhựa, phenol, phlobatannin, phytosterol, polyuronid, saponin, tanin, tinh dầu và xanthoprotein. Chè đại trồng ở điều kiện nắng có hoạt tính kháng oxy hóa cao hơn môi trường ngập nước và môi trường bóng râm, với EC50 tương ứng là 40,92±1,86, 265,73±19,49 và 294,36±19,55 µg/mL. Cao chiết lá Chè đại có khả năng kháng 3 dòng khuẩn là Bacillus cereus, Bacillus subtilis, Escherichia coli nhưng không có hiệu quả với Salmonella sp. và Staphylococcus aureus. Kết quả nghiên cứu cho thấy Chè đại có tiềm năng gia tăng giá trị dinh dưỡng và sức đề kháng của vật nuôi khi bổ sung vào khẩu phần ăn.
Nghiên cứu môi trường và giá thể phù hợp để sản xuất nấm hoàng đế (Calocybe indica APK2)
Authors: Trần Thanh Thy , Lê Văn Vàng
Published: May 2022

Nấm Hoàng Đế, Calocybe indica (C. indica) APK2 là nấm ăn, có vị ngon ngọt, hương thơm đặc trưng được con người ưa chuộng. Nhân nuôi quả thể nấm C. indica trên giá thể trong điều kiện bán nhân tạo đã được nghiên cứu thành công. Kết quả nghiên cứu cho thấy nuôi cấy hệ sợi nấm C. indica trên môi trường bán tổng hợp (potato dextrose agar (PDA) bổ sung muối khoáng) là phù hợp nhất, sau 20 ngày cho hệ sợi nấm ăn kín bề mặt môi trường, sợi tơ tốt, dày, phân nhánh nhiều. Môi trường nuôi bào tử, hạt bắp có tốc độ lan tơ tối ưu sau 20 ngày nhân nuôi. Giá thể nuôi trồng quả thể, mùn cưa tạp gồm cao su và bồ đề (7:3) (70%) + bột cám gạo ST20 (16%) + rơm rạ ST20 (14%) (MH2) đạt tốc độ lan tơ nhanh nhất ở 28 ngày sau khi chủng và năng suất nấm tươi đạt 16,35 kg/m2. Kỹ thuật này có thể ứng dụng sản xuất nấm Hoàng Đế quy mô công nghiệp để đáp ứng nhu cầu thị trường về thực phẩm nấm ăn hiện nay.
The effects of exercises with a Pilates ball on balance, reaction time and dual-task performance of kindergarten children
Authors: Obuz Tuğba , Topcu Zehra Güçhan
Published: May 2022

Aim:
This study investigated the effects of exercises conducted with a Pilates ball on the motor skills of preschool children.
Methods:
62 preschool children were randomly divided into two groups: an intervention group (IG) (n = 30) and a control group (CG) (n = 32). Exercises with a Pilates ball were practiced in IG. The One Leg Standing test, Functional Reach test, Ruler Drop test and Timed-Up and Go test were the outcome measures.
Results:
Static balance performance and dual-task performance were found to be significantly improved in the intragroup and intergroup comparisons, favoring the IG (p < 0.05).
Conclusion:
The exercises carried out in this study were found to be effective on static balance and dual-task performance. The study can guide an exercise program for the preschool age group.
Clinical Trial Registration:
NCT04575441
 (
ClinicalTrials.gov
)
Escenas lesbianas. Miradas disidentes y comunidades afectivas en torno a Victoria Ocampo
Authors: Arnés Laura A.
Published: May 2022

A partir de la relectura de ciertas escenas presentes en la revista Sur y en la Autobiografía de Victoria Ocampo (VO), este artículo sostiene que Ocampo, violentando el mandato patriarcal a ser objeto, fijó, a través de su mirada, un régimen afectivo alternativo que fue, también, un modo de conocimiento diferencial. Pero, además, a partir de la lectura de la correspondencia de VO, procuro darle cuerpo a un archivo cultural y afectivo que pasó desapercibido para la crítica hegemónica. Plantear el matiz de una afectividad disidente en la mirada de Ocampo y reflexionar en torno al modo en que los afectos que circulaban en su red internacional de amistades feministas y lesbianas quedaron plasmados en la escritura, implica no solo proponer un posible foco de disrupción en el sistema de representación sino, también, dar cuenta de los modos en que esta percepción diferencial moldeó formas de visibilidad que re-enmarcaron el entretejido de prácticas, maneras de ser y modos de sentir. Implica, también, leer los modos en los que en el cruce entre lo privado y público, entre lo psíquico y lo social, los cuerpos sexuales y textuales resultan inseparables. Las escenas lesbianas aparecen así interrumpiendo no solo los recorridos normativos de nuestros imaginarios sino, también, de nuestras prácticas críticas hegemónicas.
Prediction of Diabetes Using Logistics Regression Algorithms with Flask
Authors: M Sriram , J Nithish , B Harshavardhan , Muthukumar Mrs. Steffina
Published: May 2022

Abstract: The diabetes is one of deadly diseases on the planet. There are many kinds of diseases which has different assortments of issues for instance: coronary disappointment, visual deficiency, urinary organ infections and so forth. In such case the patient is expected to visit an analytic focus, to get their reports after meeting. Because of each time they need to contribute their time and cash. Yet, with the development of Machine Learning strategies we have the adaptability to look out a solution to the recent concern the main necessity of Artificial intelligence is data The collected dataset is used to build the machine learning model The necessary pre- processing techniques are applied like univariate analysis and bivariate analysis are implemented. The data is visualized for better understanding of the features and based on that a classification model is built by utilizing AI calculation The point of this investigation is to foster a framework which could anticipate the diabetic gamble level of a patient with a superior precision