bluuebunny/crossref_metadata_2025 huggingface dataset:
Critical windows of susceptibility for breast development
Authors: Palmer-Quinn Kerri , Di Pasquale Alice , Wexler Margaret , Moody Hannah
Published: February 2025

The normal growth and development of the human body is a critical and highly sensitive process. Despite humans continuously developing throughout life, there are certain periods of development which are more sensitive to adverse factors. These are known as critical windows of susceptibility and include development in utero (in the womb), the postnatal period, puberty, pregnancy and menopause. During these periods the mammary gland (breast) undergoes extensive development. Research suggests that exposure to harmful chemicals such as Endocrine Disrupting Chemicals (EDCs) during these critical periods may adversely affect normal development. In the case of in utero exposure, these effects may be programmed during early development but not manifest until adulthood. Limited research is available on how chemical exposure during these periods affects breast cancer risk. Yet some studies suggest that risk may be increased, likely due to the altered development of the mammary gland.
Pembelajaran Berbasis Proyek di SMA Islam Terpadu Assalam Martapura
Authors: Latifah Latifah , Ngalimun Ngalimun
Published: February 2025

Penelitian ini mengambarkan tentang pembelajaran berbasis proyek di SMA Islam Terpadu Assalam Martapura. Penelitian kualitatif yang dilakukan adalah menggunakan pendekatan pengolahan data ke dalam konsep dan kateori. Simbol dalam bentuk deskripsi, yang ditempuh dengan cara merubah data ke formulasi. Dalam penelotian ini dikemukakan bahwa pembelajaran berbasis proyek siswa bekerja di dalam tim, mereka menemukan keterampilan merencanakan, mengorganisasi, negosiasi, dan membuat konsensus tentang isu-isu tugas yang akan dikerjakan, siapa yang bertanggungjawab untuk setiap tugas, dan bagaimana informasi akan dikumpulkan dan disajikan. Keterampilan-keterampilan yang telah diidentifikasi oleh siswa ini merupakan keterampilan yang amat penting untuk keberhasilan hidupnya, dan sebagai tenaga kerja merupakan keterampilan yang amat penting di tempat kerja kelak. Karena hakikat kerja proyek adalah kolaboratif, maka pengembangan keterampilan tersebut berlangsung di antara siswa. Di dalam kerja kelompok suatu proyek, kekuatan individu dan cara belajar yang diacu memperkuat kerja tim sebagai suatu keseluruhan. Pendekatan Pembelajaran Berbasis Proyek dapat dipandang sebagai salah satu pendekatan penciptaan lingkungan belajar yang dapat mendorong siswa mengkonstruk pengetahuan dan keterampilan secara personal. Tatkala pendekatan proyek ini dilakukan dalam modus belajar kolaboratif dalam kelompok kecil siswa, pendekatan ini juga mendapat dukungan teoretik yang bersumber dari konstruktivisme sosial.
Tålmodighedens Poesi
Authors: Damgaard Henriksen Kirstine , Harris Emma , Rise Adrian Mie , Holm Hasenfuss Camille , Kamp Johannesen Sabine , Nyeland Molly
Published: February 2025

Denne artikel undersøger, hvordan sociale medier og samskabelse af en udstilling kan anvendes som etnografiske værktøjer i en integreret metodisk tilgang. Gennem et tre måneders samarbejde med syv unge saharawiaktivister benyttede vi sociale medier til at samskabe audiovisuelle værker til udstillingen Tålmodighedens Poesi. Denne tilgang gav os mulighed for at undersøge absurditeten i den venteposition, som disse aktivister befinder sig i som følge af en længe ventet folkeafstemning om Vestsaharas selvbestemmelse. Artiklen argumenterer for, at sociale medier og digitale metoder, der gav adgang til den antropologiske felt, tilbyder nye muligheder for at udforske saharawiaktivisme. Ved at anvende konceptet „invention“ som metodisk redskab til at facilitere performative scenarier og kreative eksperimenter skabte vi et rum til at undersøge saharawiernes oplevelser. Temaer som ventetid, poesi og absurditet fremstod som etnografiske objekter i deres fortællinger og det materiale, de delte, hvilket informerede vores løbende samskabelsesmetoder. Disse indsigter forme de desuden udstillingens materielle form og æstetik, som løbende tog inspiration fra surrealismen og fokuserede på de poetiske dimensioner af saharawiernes aktivistiske kamp. Som resultat blev absurditeten i deres venteposition omsat til en kropslig oplevelse for udstillingens publikum.
Enquete: Strippermus, bodyshaming og racisme
Authors: Madsen My
Published: February 2025

Enquete: Strippermus, bodyshaming og racisme
Anmeldelse: Helle Bundgaard og Anne Line Dalsgaard: Etnografisk Tekst
Authors: Anbert Lærke Cecilie
Published: February 2025

Anmeldelse: Helle Bundgaard og Anne Line Dalsgaard: Etnografisk Tekst
Forfatterliste
Authors: Madsen My
Published: February 2025

Forfatterliste
Rancang Bangun Alat Pengolah Limbah Ternak Ayam Menggunakan Arduino
Authors: Susanto Dedi , Sandre Revas , Sukirman  , Husain Nursuci Putri
Published: February 2025

Limbah adalah sumber hasil buangan dari proses produksi atau bahan yang dikeluarkan dari sumber hasil kegiatan makhluk hidup atau alam yang tidak memiliki ilmu ekonomi. Limbah ini dapat berupa limbah padat, cair dan gas yang jika tidak ditangani dengan baik akan berdampak buruk bagi lingkungan. Salah satu limbah yang dihasilkan adalah limbah kotoran ayam baik ayam petelur maupun ayam pedaging yang memiliki potensi yang besar sebagai pupuk organik. Limbah kotoran ayam paling dominan belum dimanfaatkan secara maksimal, setiap hari ada orang yang mengkutip kotoran ayam tersebut sembari membersihkan kandang ayam. Jika limbah ini dibiarkan akan berdampak negatif pada lingkungan sekitar. Penelitian ini bertujuan untuk membuat alat pengolah limbah ternak ayam berbasis arduino. Metode penelitian yang digunakan R&D (Reseach And Development) mengunakan langkah-langkah untuk menyelesaikan masalah, serta menggunakan diagram blok sebagai cara kerja sistem alat yang dirancang. Hasil pengujian dimulai dengan memasukan bahan–bahan yang akan di olah kedalam wadah alat tersebut, kemudian sensor load cell akan mendeteksi berat beban setalah itu alat akan bekerja mengolah pupuk, kemudian motor dc akan menggerak pengaduk untuk mengaduk bahan-bahan yang ada didalam wadah lalu sensor soil moisture akan mendeteksi kelembaban pupuk yang sedang diolah. Kesimpulan dari penelitian ini alat pengolah limbah ternak ayam berbasis Arduino dapat bekerja secara efektif dan tepat.
Rancangan Web Sistem Layanan Kepuasan Pelanggan Pada G-Express
Authors: Muhamad Ammar Fahmi  , Sabri Abd Kadir Muhammad , Martani Ahmad , Chintami D.A Amaliah
Published: February 2025

Penelitian ini bertujuan untuk mengetahui dan menganalisis: merancang web sistem layanan kepuasan pelanggan pada G-Express. Pengujian Web sistem layanan kepuasan pelanggan pada G-Express. Penelitian ini dilakukan pada G-Express Jenis penelitian menggunakan penelitian kualitatif deskriftif mengenai rancangan web sistem layanan kepuasan pelanggan pada G-Express. Rancangan website mulai dari login admin dan login user. Hasil penelitian menunjukan bahwa Merancang web sistem layanan kepuasan pelanggan pada G-Express dapat membantu G-Express dalam melihat segala bentuk masalah yang dihadapi pelanggan sehingga dapat digunakan sebagai acuan untuk G-Express dalam menyelesaikan masalah aduan pelanggan dan dapat membantu G-Express dalam hal mengukur sejauh mana tingkat pelayanan yang telah diberikan kepada pelanggan. Pengujian web sistem layanan kepuasan pelanggan pada G-Express diperoleh hasil bahwa sistem dapat berjalan dengan baik, dengan demikian maka sistem ini dapat digunakan.
Rancang Bangun Alat Penakar Gula Pasir Dan Bubuk Kopi Berbasis Arduino
Authors: Mariam  , Husain Nursuci Putri , Syarifuddin Baco  , Rosmiati
Published: February 2025

Abstrak
                                                                                       
Gula dan Kopi merupakan dua dari sembilan kebutuhan penting masyarakat indonesia dan cara takarnya masih menggunakan sistem manual. Mengingat  perkembangan zaman yang semakin caggih dibutuhkan alat takar yang lebih mudah dan lebih modern. Tujuan penelitian Merancang alat penakar gula pasir dan bubuk kopi berbasis Arduino agar proses penakaran gula atau kopi lebih efektif. Metode  penelitian yang digunakan ialah Research and Development (R&D) menghasilkan alat penakar menggunakan kaypad sebagai penginput data dan Arduino memprosesnya sehingga di respon oleh motor servo, Sensor Infared dan Loadcell,  menguji keefektifan fungsi alat. Hasil pengujian alat  penakar gula pasir dan bubuk kopi berbasis Arduino dilakukan dengan menghubungkan adaptor dengan terminal, dimana adaptor menerima aliran listrik sebesar 12 volt 15 ampere, kemudian masuk pada mikrokontroler yang dimana pada penelitian ini menggunakan Arduino uno kemudian disuplay ke keypad, LCD, servo, sensor infared dan loadcell. Kesimpulan alat penakar gula pasir dan  bubuk kopi menggunakan sensor infared yang mendeteksi adanya wadah dan motor servo dengan otomatis  berhenti jika terisi sesuai  yang diinginkan.
 
Kata Kunci:  Takaran, Gula, Kopi, Loadcell,  Sensor.
 
Abstract
 
Sugar and coffee are two of the nine important needs of the Indonesian people and the dosage method still uses a manual system. Given the increasingly sophisticated times, easier and more modern measuring tools are needed. The purpose of the study is to design a granulated sugar measuring tool and arduino-affective. The research method used is Research and Development (R&D). The measuring too uses a keypad as a data input and arduino processes it, so that it is responded by servo motors, infared sensor and loadcells to test the effectiveness of tool functions. The test results of the arduino-based granulated sugar and coffe powder measuring devise were carried out by connecting the adaptor with the terminal, were the adaptor received an electric current of 12 volts 15 ampers. Then granulated  sugar and coffee grounds enter the microcontroller. Which in this study uses Arduino Uno. It is supplied to the keypad, LCD, servo, infared sensor and load cell. As the conclusion the granulated  sugar and coffee powder measuring device uses an infared sensor that detects the presence of containers and servo motor automatically stop if they are filled as desired.
 
Keywords: Dosing, Sugar, Coffee, Load Cell, Sensor.
Rancang Bangun Sistem Informasi Perpustakaan Berbasis Website Di MTs N 3 Kabupaten Lembata Provinsi Nusa Tenggara Timur
Authors: Amir Ridwan  , Martani Ahmad , Arfandy Hamdan
Published: February 2025

Perpustakaan merupakan salah satu lembaga yang penting dalam pendidikan untuk mendukung pengelolaan dan pelayanan informasi kepada pengguna, Dalam konteks ini pengembangan sistem informasi perpustakaan berbasis website menjadi solusi efektif untuk meningkatkan efisiensi dan kualitas layanan.Tujuan penelitian merancang dan membagun sistem informasi perpustakaan berbasis website di MTs N 3 Kabupaten Lembata Provinsi Nusa Tenggara Timur guna mempermudah pelayanan siswa dan meningkatkan efektivitas dalam pengelolaan data perpustakaan, termasuk pencacatan buku, peminjaman, pengembalian, serta mencari informasi buku oleh pengguna. Metode yang digunakan dalam penelitian ini adalah waterfall karena pendekatannya yang sistematis dan terstruktur, dimulai dari tahap analisis kebutuhan, desain sistem, implementasi, pengujian hingga pemeliharaan. Hasil dari penelitian ini adalah sebuah sistem informasi perpustakaan berbasis website yang memiliki fitur pada halaman utama yaitu daftar buku dan tentang perpustakaan. Sedangkan pada bagian halaman admin memiliki fitur yaitu login, dashboard, master anggota, master buku,transaksi,laporan,denda dan petugas
Rancang Bangun Aplikasi Deteksi Kesalahan Penulisan Naskah Dokumen Skripsi Berbasis Website
Authors: Rusdin Wahyudin , Nurhasanah  , Junaedy  , Suharni
Published: February 2025

Dokumen skripsi adalah salah satu syarat agar mahasiswa dapat menyelesaikan program studi di sebuah universitas. Namun pada kenyataanya mahasiswa masih sering melakukan kesalahan dalam penulisan naskah dokumen skripsi. Aplikasi deteksi kesalahan penulisan skripsi merupakan solusi untuk membantu mahasiswa dalam membuat skripsi dan mendeteksi kesalahan penulisan dokumen skripsi. Salah satu metode indexing untuk meng-indeks teks biasa, untuk mengurangi kapasitas pemakaian storage dan meningkatkan kinerja searching adalah Full Text Indexing. Full Text Indexing merupakan metode yang digunakan dalam mencari kesalahan dalam sebuah teks sebagai alat bantu utama dalam perancangan aplikasi ini. Pada metode Full Text Indexing terdapat 2 tahap yang dilakukan sebelum dilakukan pencarian kata, yaitu tahap tokenizing dan tahap cleansing. Aplikasi deteksi kesalahan penulisan naskah dokumen skripsi dibuat dengan fitur pengecekan kesalahan penulisan. Selain itu, aplikasi ini memiliki fitur preview sebagai fitur untuk menampilkan hasil data yang disimpan pada halaman 1 sampai selesai, dan juga menampilkan daftar kamus data yang telah disimpan. Dengan dibuatnya aplikasi ini diharapkan agar aplikasi ini bisa membantu mahasiswa dalam pembuatan skripsi, terutama dalam pengecekan kesalahan penulisan skripsi.
Rancang Bangun Aplikasi Pemanggil Nomor Antrian Berbasis Website Untuk Meningkatkan Efisiensi Loket Pelayanan Di Puskesmas Lambale
Authors: Astita Asri , Arfandy Hamdan , Burhanuddin Nur Isnayanti
Published: February 2025

Pelayanan kesehatan Puskesmas Lambale yang mencakup 15 desa masih menerapkan sistem antrian manual, sehingga menyebabkan waktu tunggu pasien yang lama dan menghambat efisiensi pelayanan. Penelitian ini bertujuan untuk merancang dan menerapkan aplikasi pemanggil nomor antrian berbasis website guna meningkatkan efisiensi loket pelayanan. Metode yang digunakan dalam penelitian ini mencakup analisis kebutuhan pengguna melalui observasi langsung dan wawancara dengan petugas loket serta pasien. Proses perancangan sistem dilakukan menggunakan diagram flowchart, use case dan pengembangan sistem berbasis model waterfall. Aplikasi ini dibangun menggunakan bahasa pemrograman PHP dengan framework Laravel, sementara MySQL digunakan sebagai basis data. Aplikasi ini memiliki dua jenis akses utama: pengguna (pasien) dan admin. Pengguna dapat mendaftar, mengambil nomor antrian serta memantau status antrian secara real-time melalui website. Sementara itu, admin memiliki akses untuk mengelola data pasien, memantau antrian dan mengatur jadwal dokter. Pengujian dilakukan menggunakan metode black-box yang fokus pada fungsionalitas sistem. Hasil pengujian menunjukkan bahwa semua fitur aplikasi berfungsi sesuai dengan spesifikasi yang telah dirancang. Aplikasi ini mampu mengurangi waktu tunggu pasien secara signifikan dan meningkatkan efisiensi pelayanan loket, sehingga memberikan pengalaman yang lebih baik bagi pasien serta memudahkan pengelolaan antrian oleh petugas. Dengan demikian, aplikasi pemanggil nomor antrian berbasis website ini berhasil diimplementasikan dengan baik dan memberikan solusi efektif dalam mengelola antrian di Puskesmas Lambale.
Rancang Bangun Alat Monitoring Suhu Kendaraan Menggunakan Sensor DHT 11 Berbasis Internet of Things
Authors: Abdul Rahman Salahuddin , Muddin Saripuddin , Baco Syarifuddin
Published: February 2025

Overheating pada mobil terjadi ketika suhu mesin melebihi batas normal, biasanya disebabkan oleh masalah pada sistem pendingin. Penyebab utamanya meliputi kekurangan cairan pendingin (coolant), kebocoran pada sistem pendingin seperti radiator atau selang, dan kerusakan pada komponen penting seperti thermostat, kipas radiator, atau pompa air. Penelitian ini bertujuan untuk merancang dan membangun sistem monitoring suhu kendaraan berbasis Internet of Things (IoT) menggunakan sensor DHT11. Sensor DHT11 mampu mendeteksi suhu dan kelembaban secara real-time dengan tingkat akurasi yang memadai. Metode penelitian yang digunakan adalah Research and Development (R&D), yang bertujuan untuk menghasilkan produk yang efektif dan menguji kinerjanya. Sistem ini menggunakan mikrokontroler yang terhubung dengan jaringan internet untuk mengirim data suhu ke platform IoT yang dapat diakses melalui perangkat seluler atau komputer. Data yang dikirim akan ditampilkan dalam bentuk derajat celcius untuk suhu dan mililiter untuk Radiatornya supaya mempermudah pemantauan Terhadap sopir (pengguna). Hasil pengujian dari alat ini menyimpulkan bahwa sistim mampu memberikan informasi suhu kendaraan secara real-time dengan pegukuran suhu mobil yaitu Rendah 0% - 40%, Tinggi 45% - 100%, Serta Level Air 0ml - 100ml.
Sistem Pakar Analisis Kesehatan Jantung Menggunakan Metode Photopethismography (PPG) Berbasis Internet of Things (IoT)
Authors: Ningsih Sri Wahyuningsih , El Fazza Fahri , Burhanuddin Nur Isnayanti
Published: February 2025

Jantung merupakan organ tubuh manusia yang memiliki fungsi vital, kelainan kecil bisa berpengaruh besar pada kinerja kesehatan manusia.Untuk memantau kondisi detak jantung  dibuatkan alat sistem pakar analisis kesehatan jantung menggunakan metode Photoplethysmography (PPG) berbasis Internet of Things (IoT) dirancang untuk memantau detak jantung secara real time. Alat ini menggunakan NodeMCU ESP8266, pulse sensor, dan aplikasi blynk untuk mengukur dan menampilkan detak jantung. Untuk mengetahui keakuratan alat dilakukan pengambilan data sampel sebanyak 7 orang lansia dengan rentan usia 60-75 tahun dengan lansia perempuan sebanyak 6 orang dan laki-laki 1 orang. Sistem ini bekerja dengan menggunakan teknik photoplethismography (ppg) untuk mendeteksi detak jantung. Tampilan dari sistem pakar ini berupa grafik detak jantung dengan kondisi normal, takikardia, dan bradikardia. Kondisi normal apabila detak jantung berada pada angka 60-100 beat per minute (bpm) dan bradikardia kondisi ketika jantung berdetak lebih lambat dari normal sedangkan takikardia dimana kondisi detak jantung di atas 100 bpm. Pengujian terhadap alat ini menunjukkan tingkat error tertinggi atau kesalahan pengukuran maksimum sebesar 0,74% dan memiliki keakuratan sebesar 90%. Alat ini diharapkan dapat memberikan solusi praktis bagi lansia dalam memantau kondisi detak jantung tanpa harus mengunjungi fasilitas medis, sekaligus membuka peluang pengembangan lebih lanjut seperti pengukuran oksigen darah (SpO2) dan bisa mencoba menggunakan sensor lain untuk mendeteksi detak jantung.
Konwencja kapsztadzka i protokół lotniczy – analiza wybranych zagadnień
Authors:   Katedra Prawa Międzynarodowego i Stosunków Międzynarodowych Wydziału Prawa i Administracji Uniwersytetu Łódzkiego, Osiecki Mateusz
Published: February 2025

Artykuł ma na celu zapoznać czytelnika z wybranymi zagadnieniami Konwencji o zabezpieczeniach międzynarodowych na wyposażeniu ruchomym (dalej: Konwencja) z 2001 r. oraz sporządzonego doń Protokołu dotyczącego zagadnień właściwych dla sprzętu lotniczego (dalej: Protokół) z zaakcentowaniem tych aspektów, które wiążą się z obrotem handlowym w lotnictwie cywilnym. Na samym wstępie omówiono centralne dla obu aktów pojęcie „zabezpieczenia międzynarodowego” oraz wskazano, jakie typy umów mają do niego zastosowanie oraz co w ogóle może być ich przedmiotem. W dalszej kolejności w artykule przedstawiono wymogi co do formy, chwili i miejsca zawarcia umowy, z której wynika zabezpieczenie, a następnie uszczegółowiono wymagania, jakim poddane są umowy leasingu i sprzedaży samolotów, czyli najczęściej występujące w obrocie czynności zmierzające do powiększania fl oty przez linie lotnicze. Sporą część artykułu poświęcono środkom zaradczym, jakie może wykorzystać wierzyciel w sytuacji, gdy dłużnik uchyla się od wykonania obowiązków lub gdy dochodzi do jego upadłości wraz z krótkim omówieniem konsekwencji stosowania takich środków w wymiarze praktycznym. I choć na podstawie przepisów Konwencji i Protokołu umacnia się pozycja wierzyciela, jej autorzy zadbali także o to, aby dłużnicy byli chronieni przed nadużyciami drugiej strony. Tej kwestii poświęcono śródtytuł VII. Wyróżnikiem Konwencji jest instytucja rejestru międzynarodowego służąca pewności obrotu i dbałości o ochronę interesów tych, którzy wpisu do niego dokonali w pierwszej kolejności. Oba akty zaś drobiazgowo określają sytuację stron umowy, w przypadku upadłości dłużnika i przyznają ochronę wierzycielom zależną od posiadanego przez nich pierwszeństwa według rejestru międzynarodowego. Zagadnienia te zostały omówione w śródtytule IX. Ostatnia część artykułu to krótkie studium skutków ekonomicznych, jakie wiązałyby się z ewentualnym przyjęciem przez Polskę obu aktów.
Decoding Sentiment in Online Communication: A Social Media Analysis of Fashion Companies
Authors:   Institute of Economics, Finance and Management, Faculty of Management and Social Communication, Jagiellonian University, Poland, Mania Karolina , Jedynak Monika ,   Institute of Economics, Finance and Management, Faculty of Management and Social Communication, Jagiellonian University, Poland, Kuźniarska Aneta ,   Institute of Economics, Finance and Management, Faculty of Management and Social Communication, Jagiellonian University, Poland, Woszczyna Karolina ,   Institute of Economics, Finance and Management, Faculty of Management and Social Communication, Jagiellonian University, Poland
Published: February 2025

Purpose: The aim of this article was to identify differences in the emotional tone of verbal messages published on the Facebook accounts of selected companies within the fashion industry, focusing on organizations with an active presence on this platform.

Design/methodology/approach: The sentiment analysis was conducted using the CLARIN software suite. Over a three-month period in 2023, companies’ posts and users’ comments were collected and analyzed. Sentiments were categorized into six groups: ambiguous statements, strong and weak negative statements, strong and weak positive statements, and neutral statements. Analysis was performed at sentence, document, and aspect levels, employing both lexicon-based methods and machine learning.

Findings: The results showed a preponderance of strong positive sentiment among the messages seen on the social media channels of the companies analyzed.

Research limitations/implications: The study was limited to a three-month data collection period and focused exclusively on organizations within the fashion industry with an active Facebook presence, which may limit the generalizability of the findings to other industries or platforms.

Originality/value: This study contributes to the understanding of how corporate communication on social media impacts its users, offering insights specifically into sentiment dynamics within the fashion industry.
The Influence of Physical Activity on Body Mass Index Values in Adolescents
Authors: Bijelić Radojka , Brčić Halilagić Vinka , Petković Vesna
Published: February 2025

Physical activity as an important factor of proper growth and development today, under the influence of modern technologies, is causing a decline in the interest of young people, which results in an increase in BMI and the development of obesity. The goal. The aim of the work was to examine the influence of physical activity on BMI values in adolescents. Methods. The respondents were students from the first to the third grade of the Bihać secondary medical school, of both sexes. The time of data collection is November 2022. There were a total of 120 respondents. They were divided into two groups, working and control, with 60 students each. The working group consisted of students who did not engage in any physical activity, while the control group consisted of students who engaged in physical activity 1x-3x a week. Results. The mean value of BMI in the working group of students was 29.14 kg/m² compared to the mean value of BMI of the control group, 21.75 kg/m² (p= 0.044). BMI values among students from the first to the third grade of the working group were equal, without statistical significance (p= 2.785). In the control group, the BMI values were also equal, but lower compared to the BMI values of the working group. According to gender, the boys of the working group had a mean BMI of 29.26 kg/m², compared to the boys of the control group, BMI of 21.71 kg/m² (p= 0.000). The same is true for girls, the mean BMI of the working group was 29.08 kg/m², while the BMI of the control group was 21.70 kg/m² (p=0.000). Conclusion. The absence of physical activity has a significant effect on the increase of BMI in adolescents and is a risk factor for obesity. The promotion of healthy lifestyle habits, proper nutrition and physical activity should be key features of the lives of children and adolescents.
Influence of Modified Diet and Low Grade Physical Activity on Serum Lipids in Patients With Type IIa and IIb dyslipoproteinaemia
Authors: Krehić Jasmina
Published: February 2025

Dyslipoproteinaemia, a common name for different types of serum lipid disorders, plays one of the crucial roles in the etiology of atherosclerosis. Complications of atherosclerosis, primarily coronary heart disease (CHD), in early life lead to significant disability and are the worldwide leading cause of death. Treatment of dyslipoproteinaemia, as a separate disease, is carried out as a part of the treatment of CHD, and includes non-pharmacological and pharmacological measures. Recognizing an underestimated value and role of dietary modifications in everyday life of patients with hypercholesterolaemia, we decided to actualize our investigation from 2000, as we witness that lipid lowering drugs are prescribed almost as soon as elevated serum lipid levels are detected. The aim of our study was to evaluate the effects of a hypolipemic diet and low grade physical activity on serum lipid/lipoprotein levels in twenty patients with primary dyslipoproteinemia Type IIa and IIb, according to Fredrickson classification. All patients with Type IIa and IIb dyslipoproteinaemias were subjected to a hypolipemic diet that is a modification of Step I, Step II (NCEP) and the Mediterranean diet for a period of four weeks. The minimum physical activity involved a daily light walk lasting at least 1 hour. Complete lipid status has been done before and after the period of four weeks. The positive effects of our modified diet were shown as a decrease of all proatherogenic lipid/lipoprotein serum concentrations, except for β-lipoprotein. Serum concentrations of antiatherogenic α-lipoprotein increased.
Modeling and Visualization of Noise Levels Near Mining Operations
Authors: Popović Zoran P. , Ilić Predrag , Stojanović Bjelić Ljiljana , Nešković Markić Dragana
Published: February 2025

The study presents an in-depth analysis of the impact of noise from mining operations, focusing on the spatial distribution of noise levels and their compliance with regulatory limits. Utilizing advanced modeling and visualization techniques, it demonstrates effective noise management strategies that ensure compliance with national regulations. Findings highlight the importance of integrating environmental assessments and technological innovations in mitigating noise pollution, underscoring the mining industry’s commitment to sustainable practices and community well-being. This research contributes valuable insights into environmental management, offering a model for balancing industrial activities with ecological and health considerations. Key findings emphasize the significance of integrating environmental assessments and technological innovations to mitigate noise pollution, showcasing the mining industry’s commitment to sustainable practices and community well-being. The study underlines the importance of noise management strategies that align with national regulations to protect both the environment and public health. Using advanced modeling and visualization techniques, the research offers valuable insights into environmental management, presenting a model for balancing industrial activities with ecological and health considerations. It contributes significantly to the understanding of noise pollution in the mining sector, proposing effective solutions for its control. This work is grounded in a broad review of literature on environmental pollution and specific studies on noise pollution’s effects on health, highlighting the broader context of industrial and urban noise sources. It presents a detailed analysis of noise levels around a specific mining operation, including modeling and visualization of noise propagation and its impact on surrounding residential areas. The conclusion drawn from this study is that through strategic planning, technological interventions, and adherence to regulations, mining operations can effectively mitigate noise pollution. This ensures that noise levels remain within acceptable limits, thereby minimizing their impact on nearby communities and contributing to a safer and more sustainable mining environment.
Management of Healthcare Worker’s Communication Aspects Physiotherapist
Authors: Vidović Aleksandra , Stojanović Stefan , Bijelić Radojka
Published: February 2025

The healthcare system, as part of the general social system, has developed and followed the general social and economic development, the development of thoughts, and new knowledge. Communication is seen as an inseparable factor of the whole socio-economic system. The health sector was unprepared for all the changes that were rapidly developing on a global level and in doing so, encountered the notions of sustainability and survival. The aim of this paper is based on the overview of the overall aspiration to understand the importance of communication of healthcare workers with a focus on managing the physiotherapist’s communication in terms of communication during preparation for training as well as care of sports injuries. An important role is played by a multidisciplinary team, which usually consists of a club doctor, physiotherapist, and competitor. The main focus of the work is the role and importance of physiotherapists in supporting doctors as well as health improvement measures before, during, and after medical therapy. Therefore, in all three phases, communication is very important before, during, and after the completed treatment.
Impact of diverse enterprises on productivity, profitability, employment creation, and energy management of integrated farming system under lowland conditions of Tamil Nadu, India
Authors: Arumugam Rajeshkumar , Sivalingam Ramadass , Murugesan Saravanakumar , Perumal Chandrasekaran , Manivelu Rajasekar , Subramaniam Ashok , Padmanaban Balasubramanian , Natarajan Krishnaprabu , Arunagirinathan Indhushree
Published: February 2025

A study was conducted at Tamil Nadu Agricultural University, Coimbatore, with different farming system models in a lowland ecosystem to find the most effective one. The goal was to see how combining various agricultural activities and resources impacts rice-based farming. The integrated farming system (IFS) with cropping alone (FS4), rice-based cropping system + desi poultry + fish + azolla + milch cow + goat + vermicompost + nutritional garden + fodder crop (FS1), rice-based cropping system + duck + fish + azolla + milch cow + goat + vermicompost + nutritional garden + fodder crop (FS2), rice-based cropping system + turkey + fish + azolla + milch cow + goat + vermicompost + nutritional garden + fodder crop (FS3) was carried out for 2 years during 2018–19 and 2019–2020 in non-replicated trial. Within the IFS, 0.90 hectares were dedicated to the following crop rotation: rice, followed by blackgram, and then maize. The remaining 0.10 hectares were allocated to various other agricultural activities. This 0.10 hectare was further divided as follows: fish pond unit 0.04 ha, dairy unit 0.012 ha, goat unit 0.008 ha, azolla 0.004 ha, vermicompost unit 0.004 ha, nutritional garden 0.004 ha and fodder crops 0.028 ha. The study evaluated the effectiveness of integrating various components into a rice-based cropping system. This integrated system significantly increased overall productivity, as measured by the rice grain equivalent yield. The IFS that combined cropping with ducks, fish, azolla, a milch cow, goat, vermicompost, a nutrition garden, and fodder crops (FS2) achieved the higher rice grain equivalent yield of 40,332 kg/ha, which is more than double the yield (18,569 kg/ha) achieved by the rice cropping system alone, highest net return reaching Rs. 434,554 per hectare. Additionally, the integrated FS2 system generated the highest daily return, reaching Rs. 1,191, the highest employment opportunity, offering 789 workdays per hectare per year and diverse elements led to the greatest overall energy output, energy efficiency, and improved nutritional value of the produce compared to other farming systems. For lowland farmers with 1 ha farms, research suggests that a combination of cropping systems and integrated components can significantly augment and sustain yield, monetary profits, employment generation, and soil health.
Oviductin sets the species-specificity of the mammalian zona pellucida
Authors: de la Fuente Daniel , Maroto Maria , Cajas Yulia N , Cañón-Beltrán Karina , Fernandez-Gonzalez Raul , Munoz-Maceda Ana , Sanchez-Puig Juana M , Blasco Rafael , Cots Paula , Aviles Manuel , Rizos Dimitrios , Gutiérrez-Adán Alfonso
Published: February 2025

The zona pellucida (ZP) is vital for species-specific fertilization as this barrier mediates sperm-oocyte binding. Here, we determined whether sperm from distant mammalian orders (Carnivora, Primates, and Rodentia) could penetrate bovine oocytes by examining the role of bovine oviductal fluid and species-specific oviductal glycoprotein (OVGP1 or oviductin) from bovine, murine, or human sources in modulating the species-specificity of bovine and murine oocytes. Sperm from all the species were found to penetrate intact bovine ovarian oocytes to form hybrid embryos. However, contact with oviductal fluid or bovine, murine, or human OVGP1, conferred the ZP species-specificity, allowing only the penetration of the corresponding sperm regardless of the ZP’s origin. Glycolytic and microstructural analyses revealed that OVGP1 covers the pores present in the ZP and that OVGP1 glycosylation determines sperm specificity. This suggests specific fertilization capacity is acquired in the oviduct through the ZP’s incorporation of specific oviductin.
Mapping HIV-1 RNA Structure, Homodimers, Long-Range Interactions and persistent domains by HiCapR
Authors: Zhang Yan , Han Jingwan , Xie Dejian , Shen Wenlong , Li Ping , Lau Jian You , Li Jingyun , Li Lin , Kudla Grzegorz , Zhao Zhihu
Published: February 2025

Human Immunodeficiency Virus (HIV) persists as a leading global health issue. A significant gap in knowledge exists in our understanding of long-range interactions within the HIV-1 RNA genome. To bridge this gap, we introduce HiCapR, incorporating a psoralen crosslinking RNA proximity ligation and post-library hybridization for capturing HIV RNA-RNA interactions.Leveraging HiCapR, we confirm the presence of stem structures in the key regions, such as the 5’-untranslated region(5’-UTR) and Rev Response Element (RRE) stems, and dimer sites in 5’-UTR region, which is responsible for HIV packaging. Importantly, we reveal multiple previously unknown homodimers along the HIV genome, which may have important implications for viral RNA splicing and packaging processes. Also, we uncover a wealth of unprecedented long-range interactions, particularly within the 5’-UTR of infected cells.Intriguingly, our findings indicate a pronounced reduction in long-range RNA-RNA interactions, signifying a transition from a state of abundant interactions, hence a relative loose state within infected cells to a condensed structure within virions. Concurrently, we have demonstrated the presence of stable genomic domains within virions that are instrumental in the dimerization process. These domains are preserved throughout the packaging process.Our findings shed light on the functional significance of RNA organization, including stable and persistent genomic domains, homodimerization, and long-range RNA-RNA interactions, in the splicing, packaging as well as assembly of HIV.
Impacts of Structural Properties of Myosin II Filaments on Force Generation
Authors: Ding Shihang , Chou Pei-En , Deguchi Shinji , Kim Taeyoon
Published: February 2025

Cells need intracellular forces for their physiological functions, such as migration, cytokinesis, and morphogenesis. The actin cytoskeleton generates a large fraction of the forces via interactions between cytoskeletal components, such as actin filament (F-actin), myosin, and actin cross-linking proteins (ACPs). Myosin II plays the most important role in cellular force generation. Myosin II molecules self-assemble into filaments with different structures depending on myosin II isoforms and other conditions such as pH and ionic concentration. It has remained elusive how force generation in actomyosin structures is affected by the architecture of myosin II filaments. In this study, we employed an agent-based model to investigate the effects of the structural properties of myosin II filaments on force generation in disorganized actomyosin structures. We demonstrated that the magnitude of forces and the efficiency of force generation can vary over a wide range depending on the number and spatial distribution of myosin II filaments. Further, we showed that the number of myosin heads and the length of a bare zone at the center of myosin II filaments without heads highly affect the force generation process in bundles and networks. Our study provides insights into understanding the roles of the structural properties of myosin II filaments in actomyosin contractility.
Optogenetic control of a GEF of RhoA uncovers a signaling switch from retraction to protrusion
Authors: De Seze Jean , Bongaerts Maud , Boulevard Benoit , Coppey Mathieu
Published: February 2025

The ability of a single protein to trigger different functions is an assumed key feature of cell signaling, yet there are very few examples demonstrating it. Here, using an optogenetic tool to control membrane localization of RhoA nucleotide exchange factors (GEFs), we present a case where the same protein can trigger both protrusion and retraction when recruited to the plasma membrane, polarizing the cell in two opposite directions. We show that the basal concentration of the GEF prior to activation predicts the resulting phenotype. A low concentration leads to retraction, whereas a high concentration triggers protrusion. This unexpected protruding behavior arises from the simultaneous activation of Cdc42 by the GEF and sequestration of active RhoA by the GEF PH domain at high concentrations. We propose a minimal model that recapitulates the phenotypic switch, and we use its predictions to control the two phenotypes within selected cells by adjusting the frequency of light pulses. Our work exemplifies a unique case of control of antagonist phenotypes by a single protein that switches its function based on its concentration or dynamics of activity. It raises numerous open questions about the link between signaling protein and function, particularly in contexts where proteins are highly overexpressed, as often observed in cancer.
A ‘torn bag mechanism’ of small extracellular vesicle release via limiting membrane rupture of en bloc released amphisomes (amphiectosomes)
Authors: Visnovitz Tamás , Lenzinger Dorina , Koncz Anna , Vizi Péter M , Bárkai Tünde , Vukman Krisztina V , Galinsoga Alicia , Németh Krisztina , Fletcher Kelsey , Komlósi Zsolt I , Cserép Csaba , Dénes Ádám , Lőrincz Péter , Valcz Gábor , Buzas Edit I
Published: February 2025

Recent studies showed an unexpected complexity of extracellular vesicle (EV) biogenesis pathways. We previously found evidence that human colorectal cancer cells in vivo release large multivesicular body-like structures en bloc. Here, we tested whether this large EV type is unique to colorectal cancer cells. We found that all cell types we studied (including different cell lines and cells in their original tissue environment) released multivesicular large EVs (MV-lEVs). We also demonstrated that upon spontaneous rupture of the limiting membrane of the MV-lEVs, their intraluminal vesicles (ILVs) escaped to the extracellular environment by a ‘torn bag mechanism’. We proved that the MV-lEVs were released by ectocytosis of amphisomes (hence, we termed them amphiectosomes). Both ILVs of amphiectosomes and small EVs separated from conditioned media were either exclusively CD63 or LC3B positive. According to our model, upon fusion of multivesicular bodies with autophagosomes, fragments of the autophagosomal inner membrane curl up to form LC3B positive ILVs of amphisomes, while CD63 positive small EVs are of multivesicular body origin. Our data suggest a novel common release mechanism for small EVs, distinct from the exocytosis of multivesicular bodies or amphisomes, as well as the small ectosome release pathway.
Enteric glia regulate Paneth cell secretion and intestinal microbial ecology
Authors: Prochera Aleksandra , Muppirala Anoohya N , Kuziel Gavin A , Soualhi Salima , Shepherd Amy , Sun Liang , Issac Biju , Rosenberg Harry J , Karim Farah , Perez Kristina , Smith Kyle H , Archibald Tonora H , Rakoff-Nahoum Seth , Hagen Susan J , Rao Meenakshi
Published: February 2025

Glial cells of the enteric nervous system (ENS) interact closely with the intestinal epithelium and secrete signals that influence epithelial cell proliferation and barrier formation
in vitro
. Whether these interactions are important
in vivo,
however, is unclear because previous studies reached conflicting conclusions [1]. To better define the roles of enteric glia in steady state regulation of the intestinal epithelium, we characterized the glia in closest proximity to epithelial cells and found that the majority express
PLP1
in both mice and humans. To test their functions using an unbiased approach, we genetically depleted PLP1
+
cells in mice and transcriptionally profiled the small and large intestines. Surprisingly, glial loss had minimal effects on transcriptional programs and the few identified changes varied along the gastrointestinal tract. In the ileum, where enteric glia had been considered most essential for epithelial integrity, glial depletion did not drastically alter epithelial gene expression but caused a modest enrichment in signatures of Paneth cells, a secretory cell type important for innate immunity. In the absence of PLP1
+
glia, Paneth cell number was intact, but a subset appeared abnormal with irregular and heterogenous cytoplasmic granules, suggesting a secretory deficit. Consistent with this possibility, ileal explants from glial-depleted mice secreted less functional lysozyme than controls with corresponding effects on fecal microbial composition. Collectively, these data suggest that enteric glia do not exert broad effects on the intestinal epithelium but have an essential role in regulating Paneth cell function and gut microbial ecology.
Predicting amyloid proteins using attention-based long short-term memory
Authors: Li Zhuowen
Published: February 2025

Alzheimer’s disease (AD) is one of the genetically inherited neurodegenerative disorders that mostly occur when people get old. It can be recognized by severe memory impairment in the late stage, affecting cognitive function and general daily living. Reliable evidence confirms that the enhanced symptoms of AD are linked to the accumulation of amyloid proteins. The dense population of amyloid proteins forms insoluble fibrillar structures, causing significant pathological impacts in various tissues. Understanding amyloid protein’s mechanisms and identifying them at an early stage plays an essential role in treating AD as well as prevalent amyloid-related diseases. Recently, although several machine learning methods proposed for amyloid protein identification have shown promising results, most of them have not yet fully exploited the sequence information of the amyloid proteins. In this study, we develop a computational model for in silico identification of amyloid proteins using bidirectional long short-term memory in combination with an attention mechanism. In the testing phase, our findings showed that the model developed by our proposed method outperformed those developed by state-of-the-art methods with an area under the receiver operating characteristic curve of 0.9126.
Gradient pooling distillation network for lightweight single image super-resolution reconstruction
Authors: Hong Zhiyong , Liang GuanJie , Xiong Liping
Published: February 2025

The single image super-resolution (SISR) is a classical problem in the field of computer vision, aiming to enhance high-resolution details from low-resolution images. In recent years, significant progress about SISR has been achieved through the utilization of deep learning technology. However, these deep methods often exhibit large-scale networks architectures, which are computationally intensive and hardware-demanding, and this limits their practical application in some scenarios (e.g., autonomous driving, streaming media) requiring stable and efficient image transmission with high-definition picture quality. In such application settings, computing resources are often restricted. Thus, there is a pressing demand to devise efficient super-resolution algorithms. To address this issue, we propose a gradient pooling distillation network (GPDN), which can enable the efficient construction of a single image super-resolution system. In the GPDN we leverage multi-level stacked feature distillation hybrid units to capture multi-scale feature representations, which are subsequently synthesized for dynamic feature space optimization. The central to the GPDN is the Gradient Pooling Distillation module, which operates through hierarchical pooling to decompose and refine critical features across various dimensions. Furthermore, we introduce the Feature Channel Attention module to accurately filter and strengthen pixel features crucial for recovering high-resolution images. Extensive experimental results demonstrate that our proposed method achieves competitive performance while maintaining relatively low resource occupancy of the model. This model strikes for a balance between excellent performance and resource utilization—particularly when trading off high recovery quality with small memory occupancy.