bluuebunny/crossref_metadata_2025 huggingface dataset:
More susceptible psychological status of front-line medical staff than temporary workers in China during public health emergency related to COVID-19: a cross-sectional study
Authors: Leng Kunkun , Chen Xu , Jin Binbin , Xu Yongjie , Jin Hui
Published: April 2023

Our study aimed to investigate the psychological status of medical staff and temporary workers in a fangcang shelter hospital in China and analyze the relevant factors affecting the psychological symptoms. A total of 380 participants were included in a cross-sectional online survey in a fangcang shelter hospital in Hangzhou, China, during a wave of the COVID-19 pandemic.The Psychological Questionnaires for Emergent Events of Public Health (PQEEPH) was applied to investigate psychological status of medical staff and temporary workers. Multiple linear regression models were built to analyze the relevant factors affecting the psychological symptoms. Of 380 participants, women accounted for a high proportion of medical staff, and the majority of temporary workers were men. Medical staff had higher psychological symptom scores in depression, fear, neurasthenia and hypochondria than temporary workers. Multiple linear regression analysis indicated that higher risk perception and occupational exposure of medical staff were significantly related to worse psychological symptoms, and emergency management capacity was negatively correlated with psychological symptoms of medical staff. Our findings indicated that medical staff experienced more serious psychological symptoms than temporary workers during public health emergency, and protecting medical staff from psychological disturbance is of great importance to the development of medical system. Our study suggested that risk perception and protective actions should be actively improved to reduce information avoidance and develop positive psychological status, which provided scientific basis for developing psychological intervention measures when there is emergent event of public health in the future.
Yoga Pose prediction using Transfer Learning Based Neural Networks
Authors: Maddukuri Nivas , Ummity Srinivasa Rao
Published: April 2023

The rapid increase of the technology made human to work harder irrespective of the body condition. This has caused many people with mental pressure and lack of body fitness. Covid – 19 has also shown the serious effect on human mental health. Therefore, many physicians suggested to practice yoga for breathing and physical fitness. But it is not possible for all people to come to fitness centers in lockdown, tight work schedule, staying far from fitness centers etc. So, this research uses transfer learning approach on convolutional neural networks in order to predict the yoga posture made by the person in real – time. 85 different types of yoga postures dataset is constructed by web scrapping and by capturing the images which is more compared to existing works. Training, validation and test set were divided in the ration 70:10:20 respectively. The pre-trained models like EfficientNet – B0, Xception, ResNet – 50 and MobileNet were chosen based on their past performances and were trained on the constructed yoga dataset. The experimental results shows that, Xception model using transfer learning gave the best results with the testing accuracy of 95.67% and also second best in execution time.
Study on the Response Characteristics of Elevated Cylindrical Liquid Storage Tanks under Seismic Excitation
Authors: Ren Jiaqi , Yang Wenwei , Wang Yin
Published: April 2023

In seismic analysis, the undesirable mode of oscillation is determined using analytical and numerical approaches. El Centro earthquake response spectrum plot and El Centro accelerogram are used to compute the response to the seismic event and to compare the results of time-history analysis. The ANSYS software is used for all of the analyses. FE software ANSYS used spectrum and time-dependent analysis to calculate seismic response to earthquake loading. The method of response spectrum is preferable when merely considering the overall reaction of a linearly behaving structure because it requires less processing effort. Time-history analysis has the advantage of being universal. Compared to other approaches, this one has a disadvantageous computational time and convergence issues. The results of the dynamic analyses were in close agreement with one another. Regardless of the shape of the vessel, this method can be used. Additionally, slenderness characteristics can be applied to various tank shapes, such as the intze (truncated conical) or truncated intze (truncated conical). The mass, height and stiffness values of the equivalent circular tank shall be utilized. Analysis of rectangular storage tanks subjected to earthquake excitations is the focus of this study. The tank can be used both above and below ground. Predicting the natural frequencies has been done using a linear three-dimensional finite element method. The tank's height-to-length ratio, soil type, water level, and tank wall thickness are some of the variables that can be used to analyze the tank's performance. Full tanks have higher top displacement and axial force components than half-full (31%), and empty tanks (75 percent). According to the underground tank, empty tank top displacement and axial force components are higher than those in half-full (19%) and full tank circumstances (40 percent). Tank cases that are located above ground have higher base shear values than those that are located below ground (19 percent to 37 percent). Soil type 2 has a stronger shear foundation than soil type 1. (17 percent to 28 percent).
Investigation on Heat and Mass Transfer Characteristics and Parameter Design of the Maisotsenko Saturator
Authors: He Weifeng F. , Shi Qile , Adam Abdalazeem , Yao Zhaohui , Gao Yanfei , Su Pengfei , Han Dong
Published: April 2023

The Maisotsenko gas turbine cycle (MGTC) introduces the M-cycle in the aftercooling process, thereby adding a larger mass flow rate to the saturator. However, this imposes strict requirements on the lightweight design of the aftercooling saturator, for which detailed manufacturing information is currently scarce. This paper presents a comprehensive MGTC that combines intercooling, aftercooling, and regenerative, and considers the reuse of cooling water and energy recovery. The thermodynamic indicators are obtained by establishing energy and mass conservation models for each component. A heat and mass transfer model is developed for the aftercooling saturator, and the actual dimensions and internal temperature, relative humidity, and humidity ratio changes are calculated using the finite difference method. The response patterns of channel length to changes in parameters such as pressure ratio, dew point efficiency, and extraction ratio are analyzed. The results show that with a pressure ratio of 16, a dew point efficiency of 0.8, and an extraction ratio of 1/3, a channel length of 5.526m is required, with a corresponding channel number and total heat transfer area of 317 and 1752m2, respectively, and a thermal efficiency of 48.63%. The study provides a key thermal design scheme for the aftercooling saturator.
Based on the NF-κB signaling pathway to explore the predictive effect of DNA repair gene PARP1 on distant metastasis after Breast cancer surgery
Authors: Pan Kaiyong , Li Xiabin , He Junfang , Lei Yuqian , Yang Yongxin , Jiang Deyong , Tang Yan
Published: April 2023

Backgroud: To study the expression of the expression of NF-κB proteins (IKKβ, p50, p65, TNF-α) and PARP1 in patients with distant metastasis and non-metastasis after Breast cancer surgery, and analyze their correlation. Their immunohistochemical scores were used to predict their effect on postoperative distant metastases in Breast cancer patients.
Methods：Nested case-control study was used. Patients with distant metastasis in the Breast cancer follow-up cohort established in 2014 were selected as the metastasis group, while non-metastasis were selected as the control group. Immunohistochemical methods were used to detect the expression of NF-κB proteins (IKKβ, p50, p65, TNF-α) and PARP1 in the Breast cancer patients. ROC was used to analyze the predictive effect of these on distant metastasis after Breast cancer surgery. COX model was used to evaluate the effects of PARP1 and TNF-α on distant metastasis after Breast cancer surgery.
Results: (1) PARP1 was mainly expressed in the nucleus of Breast cancer cells. IKKβ, p50, p65 and TNF-α proteins were mainly expressed in the cytoplasm. And the Immunohistochemical score of them both are significantly higher in the group of distant metastasis than non-metastasis (P<0.001).(2) PARP1 was correlated with IKKβ, p50, p65 and TNF-α proteins (P<0.001). There was a correlation between IKKβ, p50, p65 and TNF-α proteins (P<0.001). (3) ROC curve showed that PARP1>6, IKKβ>4, p65>4, p50>2, TNF-α>4 had a predictive effect on distant metastasis.(SePARP1=78.4%, SpPARP1=79.4%, AUCPARP1=0.843; SeIKKβ=51.55%, SpIKKβ=64.95%, AUCIKKβ=0.591; Sep65=88.66%, Spp65=46.39%, AUCp65=0.716; Sep50=60.82%, Spp50=69.07%, AUCp50=0.6884; SeTNF-α=64.95%, SpTNF-α=70.10%, AUCTNF-α=0.709.)(4) COX analysis showed that the high expression of PARP1 and TNF-α were risk factors for distant metastasis after Breast cancer surgery (RRPARP1=4.092, 95%CI:2.475-6.080, P<0.001),(RRTNF-α=1.825, 95%CI:1.189-2.779, P=0.006).
Conclusion:(1)PARP1, IKKβ, p50, p65 and TNF-α were positively correlated with distant postoperative metastasis of Breast cancer.(2) When PARP1>6, IKKβ>4, p50>2, p65>4, TNF-α>4, it has a certain predictive effect on postoperative metastasis of Breast cancer;(3)PARP1 may regulate the effect of TNF-α on Breast cancer metastasis through NF-κB signaling pathway, providing clues for the molecular mechanism of Breast cancer metastasis.
An accelerated simulating method for flow forming process through locally and dynamically rigidifying the workpiece
Authors: Dong Yunda , Zhan Mei , Lyu Wei , Fan Xiaoguang , Zhai Zhuolei
Published: April 2023

Flow forming is a widely used process for manufacturing tubular parts in the aerospace and defense industries. In this process, the workpiece is produced locally and continuously under the action of mandrel and feed of roller(s), which requires a lengthy finite element simulation (FES) time. To speed up the FES, dynamic rigidifying the portion of workpiece which undergoes little or no deformation is an available method to reduce the amount of calculation. The mobile region that deforms plastically during the process can be identified based on the position of the roller(s) and then projected onto the designed workpiece to construct the rigid-flexible coupling model. This identification can be accelerated by clustering the elements of workpiece into a sequence of blocks along the axial or hoop direction, or both. Thus, the workpiece can be subdivided into blocks or simply into rigid and deformable parts along the intersections of the blocks. In addition, the partitioned workpiece is overlaid by a structured mesh to store the historical data during process and ensure accuracy. By integrating the above methods, the local and dynamic rigidification method can be applied to simulate the flow forming process via the secondary development of Abaqus. Comparing the precision and efficiency of models divided along diverse directions, the model divided along the axes has the optimal performance and can reduce the calculation time by 1/4 to 1/3. When the workpiece is cut only at the interfaces between rigid and deformable parts, the FES results for the large radius model show that rigidification performs well with large reduction.
Antioxidant potential, lipid profile and sensory attributes of a functional yogurt formulated with hydroethanolic extract of Mentha Piperita L.
Authors: Guemidi Chafika , Saada Djamal Ait , Chabane Ouiza Ait , Elmastas Mahfuz , Erenler Ramazan , Yilmaz Mustafa Abdullah , Tarhan Abbas , Akkal Salah , Khelifi Haroune
Published: April 2023

This study aims to quantify and identify phenolic compounds in the hydroethanolic extract of Mentha piperita L. harvested in the Algerian Sahara by colorimetric and LC-MS/MS analysis, assess its antioxidant capacity by DPPH and ABTS assays and examine the impact of its inclusion at 2 to 6% rates on sensory and oxidative properties (DPPH, ABTS, TEBARS) and the lipid profile analyzed by GC-FID in steamed yoghurt.
The extract contained 41.29 mg GAE/ml total phenolics, 22.45 mg QE/ml total flavonoids and only 0.59 mg CE/ml condensed tannins. LCMS/MS analysis detected 26 phenolic compounds, among which rosmarinic acid was the most abundant. DPPH and ABTS assays showed IC50 values of 3.18 and 2.49 mg freeze-dried extract/ml, indicating the high antioxidant potential of the examined extract. Yogurts containing 2% and 4% of this extract were well accepted by the sensory evaluation panel.
The studied extract also significantly increased the antioxidant capacity of yogurt up to 39.51% compared to natural yogurt after 20 days of refrigeration, significantly reduced lipid peroxidation and at a dose of 4%, caused a significant improvement (p<0, 01) in the omega content of yogurt, especially alpha-linolenic acid, compared to the control and caused a marked decrease (p<0. 01) in the ω-6/ω-3 ratio in yogurt from 5.21 to 4.11 on day 20 of refrigeration compared with the control. The production of a sensorially acceptable pasteurized yogurt enriched with up to 4% hydroethanol extract of Mentha piperita L. as an alternative to synthetic antioxidant additives with health-promoting properties appears feasible.
Ultrastructural modifications induced by an attenuated SARS-CoV-2-related pangolin coronavirus GX_P2V(short_3UTR) in Vero cells
Authors: Wei Lai , Che Fuyou , Lu Shanshan , Li Mengzhe , An Xiaoping , Fan Huahao , Tong Yigang , Song Lihua
Published: April 2023

Background Positive-strand RNA viruses, such as SARS-CoV-2, manipulate host cell endomembranes to form viral replication organelles (vROs) for replication and protection. Pangolin coronavirus GX_P2V(short_3UTR), a cell-culture-adapted SARS-CoV-2-related coronavirus with a 104-nucleotide deletion in its 3´-terminus untranslated region, is highly attenuated in both in vitro and in vivo infection models. The mechanism underlying this attenuation remains unclear.Methods Vero cells were infected with GX_P2V(short_3UTR) and analyzed using transmission electron microscopy at various time points post-infection.Results Our study demonstrated that GX_P2V(short_3UTR) enters cells via endocytosis, leading to the formation of delayed vROs, composed of double-membrane vesicle, convoluted membranes, and double-membrane spherules. These structures were only observed after 12 hours post-infection. At 24 hours post-infection, vROs were readily identifiable, including the formation of annular lamellae due to nuclear pore stacking. By 48 hours post-infection, infected cells exhibited a characteristic feature of a complex reticulovesicular network. Similar to SARS-CoV-2, GX_P2V(short_3UTR) were found to bud within endoplasmic reticulum-Golgi compartments, accumulate in autophagy-like vesicles and multivesicular bodies, and egress via the lysosomal pathway. Notably, we did not observe any large vacuoles containing highly dense viral particles, which had been reported in SARS-CoV-2-infected cells.Conclusions Pangolin coronavirus GX_P2V(short_3UTR) undergoes a typical SARS-CoV-2-like life cycle in Vero cells. The delayed formation of vROs and the sparsely populated viral vacuoles in infected cells could contribute to the attenuation of pangolin coronavirus GX_P2V(short_3UTR).
Left atrial appendage thrombus and PFO in a patient diagnosed TIA with sinus rhythm: a case report
Authors: Yin Li-li , Li Yan-hua , Xie Wen-li , Geng Zhao-hong , Zhang Li-jiao , Liu Zhen-zhu , Mei Jia-jie
Published: April 2023

Background The detachment of the left atrial appendage(LAA) thrombus is the major cause of cardioembolic stroke(CES)/cardioembolic transient ischemic attack(CETIA). A LAA thrombus is very infrequently detected in the presence of sinus rhythm. Patent foramen ovale(PFO) is another common reason for CES/CETIA, especially among young and middle-aged people.Case Presentation We reported a case of a 46-year-old man who presented with TIAs and was subsequently found with PFO and LAA thrombus despite being in sinus rhythm and basically normal structure and function. Anticoagulant treatment was effective, and there was no recurrence of TIA or stroke.Conclusion LAA thrombus could occur in sinus rhythm and normal structure and function. The PFO may be an innocent bystander in the patient suspected of CES/CETIA. Percutaneous PFO closure should be cautiously chosen.
Application of Accounting Software and Enterprise Productivity——Evidence from Unlisted Companies
Authors: Jiang Allen
Published: April 2023

The existing research on the economic consequences of accounting informatization mainly focuses on enterprise resource planning (ERP) systems, but in reality, most companies are still using relatively simple accounting software. This paper empirically analyzes the application of accounting software in unlisted companies and its impact on enterprise productivity for the first time with a large sample of tax return information. We found that 75% of unlisted companies use accounting software of varied functions, but only 6% of them use ERP systems. With other factors unchanged, it is found that the productivity of enterprises using accounting software is significantly higher than that of enterprises not using accounting software, and the performance of accounting software is significantly positively correlated with productivity. This correlation is reinforced by the ability of enterprises to utilize accounting information and their growth opportunities. This paper adopts methods such as the Granger causality test and instrumental variable regression to alleviate endogeneity problems. This paper will contribute to a more comprehensive understanding of the economic consequences of accounting information systems and provide an important decision-making reference for promoting high-quality economic development.
Develop a Clinical Scoring Model Based on Noninvasive Bioindicators to Predict Fibrosis Risk in Nonobese Nonalcoholic Fatty Liver Patients
Authors: Jin Wenyi , Wang Zhiyi , Weng Jie , Pan Xianjuan , Zhou Peisen
Published: April 2023

BACKGROUND:The presence of fibrosis is the main cause of the progression of nonalcoholic fatty liver disease (NAFLD). Our study aims to develop a simple clinical scoring system and nomogram for evaluating fibrosis in non-obese NAFLD patients.METHODS:This retrospective study included 99 non-obese NAFLD patients who underwent liver biopsy in China. The clinical scoring system and nomogram were used to predict the disease progression of NAFLD.RESULTS:Of the 99 non-obese patients with NAFLD, 41 (41.1%) were fibrosis. On multivariate logistic regression analysis, age, alanine aminotransferase(AST), platelet(PLT) and red blood cell (RBC) showed significant association with fibrosis (all P＜0.05). The area under curves (AUC) of the prediction model of fibrosis for non-obese patients established by the above four variables was 0.94 (95% confidence interval (CI):0.89-0.98). Moreover, the AUC of the further simplified clinical scoring model was 0.92 (95%CI 0.86-0.97). High risk group with score greater than or equal to 5, and low risk group with score less than or equal to 2. The nomogram had a good effect in evaluating the risk of fibrosis in non-obese NAFLD patients.CONCLUSION:A simple, easily calculated and non-invasive clinical score can reliably assess the presence of fibrosis in non-obese NAFLD patients. This scoring model complements the deficiency of the prediction system for disease progression in non-obese NAFLD patients, and brings good news for early identification and intervention of these patients.
High levels of Tfh/B-cell gene expression suggests poor prognosis in systemic chronic active Epstein-Barr virus disease
Authors: Miyoshi Hiroaki , Kawamoto Keisuke , Sato Kensaku , Takeuchi Mai , Nakashima kazutaka , Mori Kyohei , Miyawaki Kohta , Kato Koji , Kohno Kei , Furuta Takuya , Yamada Kyohei , Moritsubo Mayuko , Kimura Hiroshi , Ohshima Koichi
Published: April 2023

Systemic chronic active Epstein-Barr virus (CAEBV) disease is presumed to be caused by abnormal immunity toward EBV; however, its biological mechanism remains unknown. We investigated invasive immune-cell gene and EBV gene expressions in systemic CAEBV disease by comparing EBV-positive T-/NK-cell lymphomas (extranodal NK-/T-cell lymphoma [ENKTL] and EBV-positive nodal T- and NK-cell lymphoma [EBV-N-TNKL]). Gene expression profiling revealed a correlation between the expression levels of follicular helper T (Tfh)-cell and B-cell genes in systemic CAEBV disease. When we divided the patients into two groups according to the number of B-cells by immunohistochemistry, the B-cell high-count group showed a poorer prognosis than the low-count group. Additionally, the high-count group had higher EBV gene levels and EBV-positive B-cell counts than the low-count group. These results suggest that the clinical symptoms may be explained by the expansion of EBV-positive B-cells, resulting in a poor prognosis. Differential gene expression analysis revealed that systemic CAEBV disease exhibited more diverse gene expression levels than ENKTL and EBV-N-TNKL. The most significant variable genes were identified as novel distinguishing markers for systemic CAEBV disease. In conclusion, Tfh-cell and B-cell gene expression and diverse gene expression levels may correlate with unique clinical symptoms and prognosis in systemic CAEBV disease.
Speech-based Detection of Multi-class Alzheimer Disease Classification Using Machine Learning
Authors: Tripathi Tripti , Kumar Rakesh
Published: April 2023

Alzheimer's disease is a severe neurological condition that affects numerous people globally with detrimental consequences. Detecting AD early is crucial for prompt treatment and effective management. This study presents a novel approach for classifying six different types of cognitive impairment using speech-based analysis, including probable AD, possible AD, MCI, memory impairments, vascular dementia, and control. The method employs speech data from DementiaBank’s Pitt Corpus, which is pre-processed to extract pertinent acoustic features. The characteristics are subsequently employed to educate five machine learning algorithms, namely KNN, DT, SVM, XGBoost, and RF. The effectiveness of every algorithm is assessed through a 10-fold cross-validation. According to the research findings, the suggested method that is based on speech obtains a total accuracy of 75.59% concerning the six-class categorization issue The proposed approach can be developed into a non-invasive, cost-effective, and accessible diagnostic tool for the early detection and management of cognitive impairment.
Effect of initial crack length, cross-head speed, and quenching on the fracture toughness of HDPE with and without UV stabilizers
Authors: Koriem A. , Singer R. , Ollick A. M. , Elhadary M.
Published: April 2023

Fracture toughness is the ability of the material to resist crack growth. The effect of cross-head speed, initial crack length, and quenching on the fracture toughness of high-density polyethylene (HDPE) is investigated in this research, the results show that the fracture toughness of both stabilized and non-stabilized samples is influenced by the cross-head speed and crack length. The effect of overheating followed by rapid cooling (quenching) is investigated for three different cooling temperatures. It is apparent that the quenching process highly affects the ductility of the polymer, where the material became very brittle.
In-depth analysis benefital effect of probiotics and fatty acids in anesis of depression
Authors: Gao Han , He Chengwei , Xin Shuzi , Hua Rongxuan , Du Yixuan , Wang Boya , Gong Fengrong , Yu Xinyi , Pan Luming , Gao Lei , Xu Jingdong
Published: April 2023

Depression is the most prevalent presenting psychiatric symptom among individuals of all ages and backgrounds, affecting approximately 300 million people worldwide. Therefore, it deserves a great deal of attention when it comes to management. An increasing body of evidence reveals that probiotics and fatty acids can improve with depression. However, the viewpoint claims that there is no effect on depression. Network meta-analyses of existing datasets provide for the estimation of comparative efficacy, the summation and interpretation of the wider context of the evidence base, and the understanding of the relative merits of different interventions. As a reason, the objective of this study was to undertake a meta-analysis to explore current evidence for probiotic or fatty acid depression therapy in order to establish a feasible option for depression patients. Data for probiotics were retrieved from 7 RCT studies (n = 394) and fatty acids from 24 RCT studies (n = 1876). The findings indicated that intervention outperforms control.
Design and validation of a questionnaire to measure the experiences of health workers (QEx-W) with a person-centered health care model
Authors: Rodríguez Martha Lucia Cárdenas , Cantor-Cruz Francy , Gutiérrez Ana María Castillo , Martínez Adriana Acosta , Martin José Raúl Gordillo , Gerometta Sandra Figueroa , Correa Amely Marieth Vargas , Gonzalez Nancy Yomayusa
Published: April 2023

Background Person-centered care seeks to empower patients and their families to participate in health care decisions. This model of care, aimed at better health outcomes and patient experience, is based on a set of determinants that affect the roles of health care providers.1–5 In addition to having an impact on performance and motivation, these determinants affect providers’ result in physical, emotional and psychological experiences with the patient and the health system. The objective of this study was to design and psychometrically validate a questionnaire to evaluate these experiences and describe the impact on health care providers.Method A survey with 23 questions and five domains was designed. It was emailed to health professionals at four institutions. The psychometric properties of construct validity were determined with factor analysis, discriminant validity with the Fornell and Lacker criteria and convergent validity with Spearman's correlation. Reliability was evaluated with the Cronbach coefficient.Results A total of 536 responses were analyzed. Three models were estimated, and the best goodness of fit was found in the 5-factor model. In the convergent validity, a rho of 0.54 (p = 0.000) was obtained, indicating a moderate correlation between the scales, and in the discriminant, AVE values greater than 0.05 were found, but none greater than the correlations between them. The alpha coefficient was 0.95 (p = 0.00), indicating high internal consistency.Conclusion The QEx-W, composed of five factors, shows high reliability and psychometric validity, so it can be used to measure the experience of Spanish-speaking workers in the health care environment.
WITHDRAWN: Beyond Westernised Curriculum: A Call to Embrace Traditional and Indigenous Design Practices in TVET Graphic Design Education in Ghana
Authors: Ofosu-Asare Yaw
Published: April 2023

This study examined the role of traditional and Indigenous design practices in technical and vocational education and training (TVET) Graphic Design education in Ghana. A survey was conducted to determine the extent to which these practices were being used in teaching and learning and the implications of their use for curriculum and teaching practices. The results demonstrate that while there is a willingness among teachers to engage traditional and Indigenous design practices in their teaching, there are also significant barriers to their implementation. The study highlights the need for more research on the engagement of these practices in TVET Graphic Design education in Ghana and the broader implications for design education in Africa. The significance of this study lies in its contribution to the growing body of research on the use of traditional and Indigenous design practices in design education, providing important insights into the barriers and opportunities for their use. This paper also provides recommendations for practice and policy that can inform the development of more effective and relevant design education in Ghana and Africa at large.
Secure and efficient online data sharing scheme using broadcast encryption with personalised message system
Authors: Yadav Snehlata , Tiwari Namita
Published: April 2023

In the healthcare industry, online data sharing has become increasingly important, but it also raises significant security concerns. To address these concerns, we propose a secure and efficient online data sharing scheme that uses a cryptographic primitive called broadcast encryption with personalised message system. This notion is applicable to many realistic broadcast services that supports IoT and cloud technology. Specifically, in our system, the data owner creates personalized data for each legitimate user in a group and then transmits a common encrypted data for the entire group in a way that completely hides the subscribed user set from outsiders. Only authorized users can recover personalised data, while all authorized consumers can decrypt the common data. Proposed scheme employs shamir secret sharing scheme to fairly distribute and reconstruct secret among various set up authority to prevent the insider attack from malicious setup authority.We highlight the security consideration in such a scenario and capture the security requirements in the security model. Subsequently, we present a concrete scheme, which is proven CPA secure under the decisional bilinear Diffie-Hellman exponent assumption. In addition, it uses asymmetric pairings whereas rest of the schemes used symmetric pairings, which in turn leads to the smaller and constant compact size ciphertext, constant decryption keys, reduced channel requirement, prevent fault attacks on symmetric bilinear map, and, enhanced performance.
Flow Of An Incompressible MHD Third Grade Fluid In An Inclined Cylindrical Pipe And Entropy Generation
Authors: Obi Boniface Inalu , Okorie Stella Ijeoma
Published: April 2023

In this study, flow of an incompressible MHD third grade fluid in an inclined cylindrical pipe and entropy generation are considered. The nonlinear momentum and energy equations for the flow presented. Regular perturbation technique employed for the solutions. The effects of some thermo-physical parameters examined. Results show that increase in the third grade parameter and the Grashof number increases both the velocity of the fluid flow and the temperature of cylindrical wall, while increase in the magnetic field parameter reduces the flow velocity. Results further show that in the third grade parameter and the Brinkman number indicates increase in temperature which enhances entropy generation number. The magnetic field parameter suppresses the temperature of the system thereby reduces entropy generation number.
Evolutionary paths that link orthogonal pairs of binding proteins
Authors: Avizemer Ziv , Martí‐Gómez Carlos , Hoch Shlomo Yakir , McCandlish David M. , Fleishman Sarel J.
Published: April 2023

Some protein binding pairs exhibit extreme specificities that functionally insulate them from homologs. Such pairs evolve mostly by accumulating single-point mutations, and mutants are selected if their affinity exceeds the threshold required for function1–4. Thus, homologous and high-specificity binding pairs bring to light an evolutionary conundrum: how does a new specificity evolve while maintaining the required affinity in each intermediate5,6? Until now, a fully functional single-mutation path that connects two orthogonal pairs has only been described where the pairs were mutationally close enabling experimental enumeration of all intermediates2. We present an atomistic and graph-theoretical framework for discovering low molecular strain single-mutation paths that connect two extant pairs and apply it to two orthogonal bacterial colicin endonuclease-immunity pairs separated by 17 interface mutations7. We were not able to find a strain-free and functional path in the sequence space defined by the two extant pairs. By including mutations that bridge amino acids that cannot be exchanged through single-nucleotide mutations, we found a strain-free 19-mutation trajectory that is completely functionalin vivo. Despite the long mutational trajectory, the specificity switch is remarkably abrupt, resulting from only one radical mutation on each partner. Each of the critical specificity-switch mutations increases fitness, demonstrating that functional divergence could be driven by positive Darwinian selection. These results reveal how even radical functional changes in an epistatic fitness landscape may evolve.
A Quasi-Spherical Net Power Fusion Reactor Based on High Temperature Superconducting Magnets
Authors: Rogers Joel G. , Egly Andrew A. , Wessel Frank J.
Published: April 2023

Particle in Cell (PIC) simulation has been used to design a quasi-spherical, net power, deuterium fueled, fusion reactor incorporating high temperature superconducting (HTS) magnets. Using the principles of Magneto-Electrostatic Trap design of Yushmanov(1980) the reactor is predicted to have power-balance Q = 7, improving on the classic Polywell design by incorporating HTS magnets and a high-current deuteron ion beam. With these improvements, a hexahedral reactor of only 4m diameter is predicted to produce 100 megawatts of net power, in a design that is suitable for practical commercial fusion power production.
Exploring Compersion: A Study on Polish Consensually Non-Monogamous Individuals and Adaptation of the COMPERSe Questionnaire
Authors: Buczel Klara A. , Szyszka Paulina D. , Mara Izu
Published: April 2023

Compersion is a positive emotion experienced in relation to one’s partner’s relationship(s) with other partner(s). Experiencing it is highly desired in communities practicing consensual non-monogamy (CNM), especially polyamory. This article presents the results of a study on compersion on Polish CNM individuals. The main goal of the study was to adapt to the Polish speaking population the COMPERSe (Classifying Our Metamour/Partner Emotional Response Scale; Flicker et al., 2021), the first standardized quantitative scale designed to measure compersion. The analyzes were performed on data obtained from 211 individuals in CNM relationships and on comparative group of 169 people in monogamous relationships. The results of the factor analyzes suggested that the 3-factor model of the original COMPERSe version did not fit well, leading to further revisions that resulted in a 7-item, 2-factor solution with excellent fit, excellent internal consistency, strong divergent and convergent validity, and excellent test-retest stability. The CNM individuals were found to have higher scores on compersion and cognitive empathy and were also less jealous than the monogamous participants. Furthermore, polyamorous individuals experienced more compersion and less aversion to partner’s autonomy than people in open relationships. It was also revealed that compersion indirectly predicted relationship satisfaction by decreasing jealousy and that compersion was, in turn, predicted by cognitive empathy. However, when polyamorous and open relationships were analyzed separately, compersion predicted relationship satisfaction directly, but only in polyamorous relationships; meanwhile, in open relationships, satisfaction was directly predicted by cognitive empathy.
Inhibition of ATR opposes glioblastoma invasion through disruption of cytoskeletal networks and integrin internalisation via macropinocytosis
Authors: Derby Sarah , Dutton Louise , Strathdee karen , Stevenson Katrina , Clough Emily , Koessinger Anna , Yu Wenxi , Tian Yuling , Gilmour Lesley , McGhee Ewan , McGarrity-Cottrell Connor , Dibekeme Aurelie anderlinden , Collis Spencer , Rominiyi Ola , Soares Leandro Lembruber , Peter  , Solecki Gergely , Winkler Frank , Carlin Leo , Inman Gareth , Chalmers Anthony , Norman Jim , Carruthers Ross , Birch Joanna
Published: April 2023

Background
Glioblastomas (GBM) have highly infiltrative growth patterns that contribute to recurrence and poor survival. Despite infiltration being a critical therapeutic target, no clinically useful therapies exist which counter GBM invasion. Here, we report that inhibition of Ataxia telangiectasia and Rad 3 related kinase (ATR) reduces invasion of GBM cells through dysregulation of cytoskeletal networks and subsequent integrin trafficking.
Methods
GBM motility and invasion was assessed both in vitro and in vivo in response to ATR inhibition (ATRi) and ATR over-expression using timelapse microscopy, two orthotopic GBM models and intravital imaging. Disruption to cytoskeleton networks and endocytic processing were investigated via high throughput, super resolution imaging and intravital imaging.
Results
High ATR expression was associated with significantly poorer survival in clinical datasets whilst GBM tumour specimens revealed higher ATR expression at infiltrative margins. ATRi opposed invasion of GBM cells due cytoskeletal dysregulation impacting integrin internalisation.
Conclusion
We demonstrate a novel role for ATR in determining invasion in GBM cells, and propose that pharmacological targeting of ATR could have far reaching clinical benefits.
The Synergic Entropy. An efficient frontier output derived from merged input units boosted by synergy and constrained by critical input
Authors: De Carvalho Videira Henrique
Published: April 2023

The theory equates the maximum output deviations (efficient frontier) caused by combined inputs with affinity-synergy in a system, which leads to a parametric volatility whose curve can be compared to data envelopment analysis (DEA). The input is a cumulative variable (e.g.: merged assets), and the output is a flow variable (e.g.: combined incomes). Rather than being purely stochastic, volatility is estimated by a novel parameter for risk named synergy, which is constrained by critical input (scarce resources). The output acceleration derived from the mergers among inputs, boosted by synergy, is the main foundation of the approach, which particular case gives Shannon and Boltzmann-Gibbs entropies. Tests are done in the 11 USA Sectors over their quarterly financial statements, proving that synergy is significant for financial statements, whereas typical betas only present significance in stock market data. A practical application is a novel discount rate for valuation using synergy, whose results for each sector are stable and coherent with perceived risk. Systems that rely on causal relations between output and multiple inputs can be regressed under novel parameters, rather than reckoning exclusively in optimization procedures.
Lessons from the Lab: SARS-CoV-2 Detection Rate amongst the Vaccinated Travel Lane and Non-Vaccinated Travel Lane Travellers into Malaysia
Authors:   BP Clinical Lab Sdn Bhd, Temasya@Glenmarie, Selangor, Malaysia, Chun Chuan Beh , Zulkufli Nada Syazana ,   BP Clinical Lab Sdn Bhd, Temasya@Glenmarie, Selangor, Malaysia, Rajesvaran Chelvam ,   BP Clinical Lab Sdn Bhd, Temasya@Glenmarie, Selangor, Malaysia, Yon Rohaizat ,   BP Clinical Lab Sdn Bhd, Temasya@Glenmarie, Selangor, Malaysia, Loke Khee Siow ,   Lovy Pharmacy Sdn Bhd, Selangor, Malaysia
Published: April 2023

Background: The vaccinated travel lane (VTL) between Malaysia and Singapore was implemented to facilitate travelling between countries without the need for quarantine. Objectives: i) Observe the rate of positive SARS-CoV-2 test results amongst inbound international travellers; ii) Explore possible factors associated with the outcome of test results between VTL and non-VTL travellers. Method: This is a retrospective cross-sectional study involving air travellers arriving in Malaysia via the Kuala Lumpur International Airport (KLIA) or Kuala Lumpur International Airport 2 (KLIA2) who were tested for SARS-CoV-2 by reverse transcriptase polymerase chain reaction (RT-PCR) from 29 November 2021 to 15 March 2022. Subject demographics and RT-PCR results were retrieved from the laboratory information system and statistically analysed. Results: Out of 118,902 travellers, mostly were Malaysian nationals (62.7%) and VTL travellers (68.2%) with a median age of 35 years old. A total of 699 (0.6%) of travellers tested positive on arrival, out of which 70.2% had cycle threshold (Ct) values > 30 (70.8% of VTL and 70.0% of non-VTL cohorts). Non-VTL travellers were 4.5 times more likely to test positive compared with VTL travellers (1.25% versus 0.28%; P < 0.001). Conclusion: Tighter entry requirements including vaccination status and testing frequency, the use of sensitive detection methods on arrival and similar public health policies between countries may have contributed to the VTL being a safe and cost-effective mode of travel.
Strength in numbers: Optimal and scalable combination of LHC new-physics searches
Authors: Araz Jack Y. , Buckley Andy , Fuks Benjamin , Reyes-González Humberto , Waltenberger Wolfgang , Williamson Sophie L. , Yellen Jamie
Published: April 2023

To gain a comprehensive view of what the LHC tells us about physics beyond the Standard Model (BSM), it is crucial that different BSM-sensitive analyses can be combined. But in general search-analyses are not statistically orthogonal, so performing comprehensive combinations requires knowledge of the extent to which the same events co-populate multiple analyses’ signal regions. We present a novel, stochastic method to determine this degree of overlap, and a graph algorithm to efficiently find the combination of signal regions with no mutual overlap that optimises expected upper limits on BSM-model cross-sections. The gain in exclusion power relative to single-analysis limits is demonstrated with models with varying degrees of complexity, ranging from simplified models to a 19-dimensional supersymmetric model.
Strategizing Methodology during the Transformation of Innovative Industrial Clusters
Authors: Kalinin Vladimir
Published: April 2023

Each innovative industrial cluster is a complex hierarchical system. To study its methodology, scientists have to investigate the movement of each structural element towards common strategic goals. Philosophy gives the theory of strategizing a harmonious development. Strategists rely on philosophers in their search for the most effective research methods. Philosophers answer the questions about the role man in the world and the way people transform the natural, economic, and social reality. An effective strategy for an innovative industrial cluster should rely on a balanced approach in order to improve the quality of life and achieve the national technological sovereignty. To strategize an industrial cluster, one needs to analyze resource availability and competitive advantages, define strategic priorities and goals, develop infrastructure, consolidate participants based on common strategic goals, etc. The paper describes research methods aimed at effective cluster strategizing, including the development, creation, dissemination, and introduction of innovations into the production process. The basic principles of the strategic decision-making system are aimed at successful innovative industrial cluster enterprises that provide rational use of innovative potential and multiply in the long run. The systematic strategic approach to financial investments is a key condition for innovation clustering during the emergency period. This decision-making system for strategic investment can help managers of an innovative industrial cluster to achieve strategic goals, maximize profitability, and secure long-term success, provided that the strategy is implemented consistently and fully.
Targeting of SOS1: from SOS1 Activators to Proteolysis Targeting Chimeras
Authors: Hamilton Gerhard , Stickler Sandra , Rath Barbara
Published: April 2023

The most frequent mutated oncogene KRAS in lung cancer is targeted by KRAS G12C-directed
drugs, such as Sotorasib and Adagrasib. Still, other alleles frequently expressed in pancreatic and colon cancer
may be attacked indirectly by hitting the guanine nucleotide exchange factor (GEF) SOS1 that loads and activates
KRAS. The first modulators of SOS1 were found to act as agonists and defined a hydrophobic pocket at
the catalytic site. High throughput screenings resulted in the detection of SOS1 inhibitors Bay-293 and BI-3406
comprising amino quinazoline scaffolds optimized for binding to the pocket by various substituents. The first
inhibitor, BI-1701963, is in clinical studies alone or in combination with a KRAS inhibitor, a MAPK inhibitor
or chemotherapeutics. An optimized agonist, VUBI-1, shows activity against tumor cells by destructive overactivation
of cellular signaling. This agonist was used to formulate a proteolysis targeting chimera (PROTAC),
that labels SOS1 for degradation by proteasomal degradation through a linked VHL E3 ligase ligand. This
PROTAC exhibited the highest SOS1-directed activity due to target destruction, recycling and removal of
SOS1 as a scaffolding protein. Although other first PROTACs have entered clinical trials, each conjugate must
be meticulously adapted as an efficient clinical drug.
Key Mutant Genes and Biological Pathways Involved in Aspirin Resistance
in the Residents of the Chinese Plateau Area
Authors: Wu Jinchun , Chang Rong , Liu Yanmin
Published: April 2023

Introduction:

Aspirin is used to prevent and treat cardiovascular diseases; however,
some patients develop aspirin resistance.

Aim:

We aimed to explore the potential molecular mechanisms underlying aspirin resistance in
people living in the Chinese plateau area.

Methods:

In total, 91 participants receiving aspirin treatment from the Qinghai plateau area were
divided into the aspirin resistance and aspirin sensitivity groups. Genotyping was performed using
the Sequence MASSarray. Differentially mutated genes between the two groups were analyzed using
MAfTools. The annotation of differentially mutated genes was conducted based on the
Metascape database.

Results and Discussion:

In total, 48 differential SNP and 22 differential InDel mutant genes between
the aspirin resistance and aspirin sensitivity groups were screened using Fisher’s exact test
(P < 0.05). After the χ2 test, a total of 21 SNP mutant genes, including ZFPL1 and TLR3, and 19
InDel mutant genes were found to be differentially expressed between the two groups (P < 0.05).
Functional analysis revealed that these differential SNP mutations were mainly enriched in aspirin
resistance pathways, such as the Wnt signaling pathway. Furthermore, these genes were related to
many diseases, including various aspirin indications.

Conclusion:

This study identified several genes and pathways that could be involved in arachidonic
acid metabolic processes and aspirin resistance progression, which will provide a theoretical
understanding of the molecular mechanism of aspirin resistance.