bluuebunny/crossref_metadata_2025 huggingface dataset:
Cryptic trans-lithospheric fault systems at the western margin of South America: implications for the formation and localization of gold-rich deposit superclusters
Authors: Wiemer Daniel , Hagemann Steffen G. , Hayward Nicholas , Begg Graham C. , Hronsky Jon , Thébaud Nicolas , Kemp Anthony I. S. , Villanes Carlos
Published: September 2023

We present a review of frontier research advances in the investigation of cryptic structures that transect the South American Andes at oblique strike directions. The intersections between these cryptic structures and the superimposed Andean belt correlate with the spatial distribution of gold-rich mineral deposit clusters. The deposit clusters can be described as superclusters, as they comprise various gold deposit types that formed at multiple times throughout the Phanerozoic, impinging repeatedly on the structural intersections. However, the cryptic inherited fault structures are difficult to detect, because their deeper-seated roots are often overlain by younger supracrustal successions, and/or their exposed surface manifestations are structurally obscured by subsequent tectonic-magmatic activity. Thus, it also remains a challenge to constrain the nature and timing of formation, and the respective subsequent evolutionary path, of these proposed pre-Andean structures. Based on various case studies, we demonstrate that the localization of identified Phanerozoic gold deposit superclusters along the western South American margin is fundamentally controlled by structural inheritance often dating back to at least the Mesoproterozoic. Integration of multi-approach observations and datasets allows insights into a larger-scale tectonic history that showcases the successive inheritance of major structures originating from the Amazonian Craton, over the Paleozoic Gondwana margin, into the Cenozoic magmatic belts of the Andes, and even into recent fractures within the subducting oceanic Nazca plate, recording >1.2-billion-years of progressive structural inheritance and growth at one of the longest-lived tectonic margins in Earth history. In contrast to previous models of the spatial distribution of gold deposits, based on statistical approaches and spatial periodicity in self-organized systems focusing on single subduction and/or accretion episodes and belts, we propose that the structural inheritance and intersections are key to the localization of gold deposits in the Andes. In combination with bulk-geochemical data from magmatic rocks, we suggest that inherited structures maintained a trans-lithospheric connectivity to pre-fertilized gold enriched upper mantle reservoirs, which were tapped during multiple tectono-magmatic reactivation episodes.
The influence of different intensity of monsoon on typhoon precipitation: a comparative study of typhoons Soudelor and Maria
Authors: Zeng Zi , Xu Jianjun , Ye Guiling , Shen Wenqi
Published: September 2023

In this paper, multiple sets of reanalysis datasets are used to analyze the intensity of the Asian summer monsoon from 1979 to 2021. Typhoon Soudelor (No. 1513) and Typhoon Maria (No. 1808) were selected from the weak monsoon year 2015 and the strong monsoon year 2018, both of which were generated in the Northwest Pacific in July and made landfall in South China. The Weather Research and Forecasting Model (WRF) was used to simulate the two typhoons, starting 48 h prior to their landfall. The reasons for the differences in precipitation and how the monsoon affects typhoon precipitation in this process are analyzed from the aspects of monsoon background, ambient weather systems, typhoon thermodynamic structure, and water vapor conditions. The analysis shows that the circulation of Soudelor was stable and maintained for a long time. Despite existing in the background of a weak monsoon, the monsoon flow was able to reach the key area affecting typhoons and inject enough warm and moist flow to affect Soudelor. Combined with the analysis of typhoon structure, the strong water vapor transport of Soudelor and increased low-level convergence were conducive to the formation of typhoon-related rainstorms. The monsoon appeared to provide environmental conditions favorable for typhoon precipitation, resulting in a wide range of precipitation and heavy precipitation. Typhoon Maria developed and changed rapidly, moved rapidly, and the precipitation maintained itself for a relatively short time. The monsoon flow was not transported into Maria, resulting in insufficient water vapor inside Maria, which prevented the strengthening of typhoon precipitation. The precipitation of Maria mainly came from the dynamics of the typhoon itself and was not affected by the monsoon. In addition, this study defines an area on the southwest side of the typhoon moving with the center of the typhoon as the key area affecting typhoons. The characteristics of this area can be simply linked to typhoon precipitation, which can be considered an important research area for future analysis and prediction of typhoon precipitation.
Accelerated telomere shortening in adrenal zona reticularis in patients with prolonged critical illness
Authors: Nonaka Keisuke , Takubo Kaiyo , Aida Junko , Watai Yoriko , Komatsu Akiko , Gomi Fujiya , Shichi Yuuki , Yamazaki Yuto , Ishiwata Toshiyuki , Sasano Hironobu , Arai Tomio
Published: September 2023

Background

The number of patients with prolonged critical illness (PCI) has been increasing in many countries, and the adrenal gland plays an important role in maintaining homeostasis during PCI. Chronic disease burden is reportedly associated with shorter telomere lengths in human tissues. Telomere shortening in human somatic cells is largely dependent on cell divisions, and critically short telomeres lead to cellular dysfunction and aging. However, the association between PCI and telomere lengths in human adrenal cells is poorly understood. In this study, we investigated this association to assess whether the burden of PCI could accelerate the aging process in adrenal cells.

Methods

Adrenocortical tissues from patients who died after PCI usually show a diffuse pattern of intracellular cholesterol ester depletion (i.e., lipid depletion). This study examined near-normal adrenal glands obtained from autopsied patients who died suddenly (control group) and lipid-depleted adrenal glands obtained from autopsied patients who died after PCI (PCI group). The control group included 7 men aged 80 to 94 years (mean age: 85.3 years) and 7 women aged 84 to 94 years (mean age: 87.7 years). The PCI group included 10 men aged 71 to 88 years (mean age: 78.8 years) and 8 women aged 77 to 95 years (mean age: 85.6 years). By using quantitative fluorescence in situ hybridization, relative telomere lengths (RTLs) were determined in the parenchymal cells of the three adrenocortical zones (zona glomerulosa, zona fasciculata, and zona reticularis [ZR]) and in the chromaffin cells of the medulla. The number of adrenal parenchymal cells was determined by immunohistochemistry and digital image analysis.

Results

RTLs in ZR cells were significantly shorter in the PCI group than in the control group for both men and women (P = 0.0001 for men and P = 0.0012 for women). However, RTLs in the remaining three types of adrenal cells did not differ between the control and PCI groups for both men and women. The number of ZR cells was higher in the PCI group than in the control group for both men and women (P < 0.0001 for both men and women). The proportion of the number of ZR cells to the total number of adrenocortical parenchymal cells was also higher in the PCI group than in the control group (P < 0.0001 for both men and women). The Ki-67 proliferation index in ZR cells was higher in the PCI group than in the control group (P = 0.0039 for men and P = 0.0063 for women).

Conclusions

This study demonstrated ZR cell-specific telomere shortening in patients with adrenal lipid depletion who died after PCI. Our results suggest that the reactive proliferation of ZR cells accelerates the telomere shortening and aging process in ZR cells in these patients. The results of our study may contribute to the understanding of adrenal aging during PCI.
Regional logistics, carbon emission index and green financial performance enhancement configuration: a comparative study based on 30 Chinese provinces
Authors: Li Muyun , Wang Lihua , Liu Zhongyan , He Qile
Published: September 2023

In recent years, because of the increasingly severe global environmental protection situation and the superimposed effect of the new crown epidemic, the importance of green finance has been highlighted and gradually elevated to an important future development strategy for the country. However, it is unclear how to improve the effectiveness of green finance in each province. Using 30 Chinese provinces and regions as research samples, this paper summarizes five influencing factors, including regional logistics, carbon emission index, regional finance, economic level, and environmental regulation. Considering the complex causal relationship between factors and green finance performance, fsQCA is used to explore the different configurations formed in the process of developing green finance in each province. The results comprise four different configurations for high performance and four types of configurations for the absence of high performance. Currently, with the regional green finance development model still in its infancy, regional logistics and carbon emission index factors play a key role in stimulating the development of green finance in the provinces and regions. This study has important theoretical and practical significance for the construction of regional green financial system and local government performance appraisal system with local characteristics in each province of China, and provides locally adapted policy suggestions for different provinces to achieve optimal allocation of resources.
RETRACTED: Research on smart grid management and security guarantee of sports stadiums based on GCNN-GRU and self-attention mechanism
Authors: Li Song
Published: September 2023

Introduction: Smart grid management and security in sports stadiums have gained global attention as significant topics in the field of deep learning. This paper proposes a method based on the Graph Convolutional Neural Network (GCNN) with Gated Recurrent Units (GRU) and a self-attention mechanism. The objective is to predict trends and influencing factors in smart grid management and security of sports stadiums, facilitating the formulation of optimization strategies and policies.

Methods: The proposed method involves several steps. Firstly, historical data of sports stadium grid management and security undergo preprocessing using the GCNN and GRU networks to extract time series information. Then, the GCNN is utilized to analyze smart grid data of sports stadiums. The model captures spatial correlations and temporal dynamics, while the self-attention mechanism enhances focus on relevant information.

Results and discussion: The experimental results demonstrate that the proposed method, based on GCNN-GRU and the self-attention mechanism, effectively addresses the challenges of smart grid management and security in sports stadiums. It accurately predicts trends and influencing factors in smart grid management and security, facilitating the formulation of optimization strategies and policies. These results also demonstrate that our method has achieved outstanding performance in the image generation task and exhibits strong adaptability across different datasets.
Going with the flow: the supply and demand of sediment retention ecosystem services for the reservoirs in Puerto Rico
Authors: De Jesus Crespo R. , Valladares-Castellanos M. , Mihunov Volodymyr V. , Douthat T. H.
Published: September 2023

Impounding surface waters in reservoirs is a major mechanism for providing water for human consumption, including potable water, hydroelectric power, and industrial uses. Building reservoirs incurs environmental and social costs, and therefore safeguarding their effectiveness and longevity is a concern of clear public interest. One factor that affects the longevity of reservoirs is sedimentation, a process exacerbated by land use conversion in upstream watershed areas. Despite the economic importance of preventing sedimentation in existing reservoirs, few consumers are aware of the natural features that provide sediment retention services and the relevance of their conservation in their daily lives. Moreover, managing for landscape level sediment retention services is challenging due to a lack of clarity regarding supply and demand flows that transcend watershed boundaries and jurisdictions. Our study seeks to bridge these gaps by characterizing the flow of sediment retention services to reservoirs and link these services to the specific consumers that benefit using a socio-ecological network (SEN) framing. We conducted this study on the island of Puerto Rico (PR), the population of which is heavily reliant on reservoirs as a primary water resource, while experiencing severe and chronic reservoir sedimentation problems. Our study models avoided sediment export, and the costs were averted thanks to this service. We characterized protection as opposed to vulnerability of these sediment retention services by estimating the proportion of natural areas under some form of legal conservation status and the level of landscape fragmentation. We frame these services as an SEN by using water distribution lines as links to estimate the number of beneficiaries and their location relative to the reservoir’s water source. Our results identify watersheds with conservation needs, their beneficiaries, and where within those watersheds to prioritize conservation efforts to safeguard access to clean water in PR. More broadly, our study provides a model case study for establishing supply and demand service flows of water purification services and demonstrating the utility of mapping socio-ecological networks of service flows in order to justify conservation policies based on ecosystem services.
Monitoring of deforestation events in the tropics using multidimensional features of Sentinel 1 radar data
Authors: Zhao Chuanwu , Pan Yaozhong , Zhu Xiufang , Li Le , Xia Xingsheng , Ren Shoujia , Gao Yuan
Published: September 2023

Many countries and regions are currently developing new forest strategies to better address the challenges facing forest ecosystems. Timely and accurate monitoring of deforestation events is necessary to guide tropical forest management activities. Synthetic aperture radar (SAR) is less susceptible to weather conditions and plays an important role in high-frequency monitoring in cloudy regions. Currently, most SAR image-based deforestation identification uses manually supervised methods, which rely on high quality and sufficient samples. In this study, we aim to explore radar features that are sensitive to deforestation, focusing on developing a method (named 3DC) to automatically extract deforestation events using radar multidimensional features. First, we analyzed the effectiveness of radar backscatter intensity (BI), vegetation index (VI), and polarization feature (PF) in distinguishing deforestation areas from the background environment. Second, we selected the best-performing radar features to construct a multidimensional feature space model and used an unsupervised K-mean clustering method to identify deforestation areas. Finally, qualitative and quantitative methods were used to validate the performance of the proposed method. The results in Paraguay, Brazil, and Mexico showed that (1) the overall accuracy (OA) and F1 score (F1) of 3DC were 88.1–98.3% and 90.2–98.5%, respectively. (2) 3DC achieved similar accuracy to supervised methods without the need for samples. (3) 3DC matched well with Global Forest Change (GFC) maps and provided more detailed spatial information. Furthermore, we applied the 3DC to deforestation mapping in Paraguay and found that deforestation events occurred mainly in the second half of the year. To conclude, 3DC is a simple and efficient method for monitoring tropical deforestation events, which is expected to serve the restoration of forests after deforestation. This study is also valuable for the development and implementation of forest management policies in the tropics.
Identification and validation of novel biomarkers associated with immune infiltration for the diagnosis of osteosarcoma based on machine learning
Authors: Ji Yuqiao , Lin Zhengjun , Li Guoqing , Tian Xinyu , Wu Yanlin , Wan Jia , Liu Tang , Xu Min
Published: September 2023

Objectives: Osteosarcoma is the most common primary malignant tumor in children and adolescents, and the 5-year survival of osteosarcoma patients gained no substantial improvement over the past decades. Effective biomarkers in diagnosing osteosarcoma are warranted to be developed. This study aims to explore novel biomarkers correlated with immune cell infiltration in the development and diagnosis of osteosarcoma.

Methods: Three datasets (GSE19276, GSE36001, GSE126209) comprising osteosarcoma samples were extracted from Gene Expression Omnibus (GEO) database and merged to obtain the gene expression. Then, differentially expressed genes (DEGs) were identified by limma and potential biological functions and downstream pathways enrichment analysis of DEGs was performed. The machine learning algorithms LASSO regression model and SVM-RFE (support vector machine-recursive feature elimination) analysis were employed to identify candidate hub genes for diagnosing patients with osteosarcoma. Receiver operating characteristic (ROC) curves were developed to evaluate the discriminatory abilities of these candidates in both training and test sets. Furthermore, the characteristics of immune cell infiltration in osteosarcoma, and the correlations between these potential genes and immune cell abundance were illustrated using CIBERSORT. qRT-PCR and western blots were conducted to validate the expression of diagnostic candidates.

Results: GEO datasets were divided into the training (merged GSE19276, GSE36001) and test (GSE126209) groups. A total of 71 DEGs were screened out in the training set, including 10 upregulated genes and 61 downregulated genes. These DEGs were primarily enriched in immune-related biological functions and signaling pathways. After machine learning by SVM-RFE and LASSO regression model, four biomarkers were chosen for the diagnostic nomogram for osteosarcoma, including ASNS, CD70, SRGN, and TRIB3. These diagnostic biomarkers all possessed high diagnostic values (AUC ranging from 0.900 to 0.955). Furthermore, these genes were significantly correlated with the infiltration of several immune cells, such as monocytes, macrophages M0, and neutrophils.

Conclusion: Four immune-related candidate hub genes (ASNS, CD70, SRGN, TRIB3) with high diagnostic value were confirmed for osteosarcoma patients. These diagnostic genes were significantly connected with the immune cell abundance, suggesting their critical roles in the osteosarcoma tumor immune microenvironment. Our study provides highlights on novel diagnostic candidate genes with high accuracy for diagnosing osteosarcoma patients.
Comprehensive analyses of m6A RNA methylation patterns and related immune microenvironment in idiopathic pulmonary arterial hypertension
Authors: Gao Gufeng , Chen Ai , Gong Jin , Lin Weijun , Wu Weibin , Mohammad Ismail Hajary Sagor , Lian Guili , Luo Li , Xie Liangdi
Published: September 2023

Idiopathic pulmonary arterial hypertension (IPAH) is a life-threatening disease with a poor prognosis and high heritability, characterized by elevated pulmonary vascular resistance (PVR) and pulmonary artery pressure. N6-methyladenosine (m6A) RNA modification influences many RNA metabolism pathways. However, the position of m6A methylation regulators in IPAH remains unknown. Therefore, the study aims to disclose the function m6A regulators exert in the pathological mechanisms of IPAH and the immune microenvironment involved. The GSE117261 dataset was downloaded from the Gene Expression Omnibus (GEO) to screen the differentially expressed genes (DEGs) between normal and IPAH samples. Functional and pathway enrichment analyses of DEGs were then conducted by Gene ontology (GO) analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG). We also identified the differentially-expressed m6A (DEm6A) regulators between normal and IPAH samples. Key m6A regulators related to the prediction of IPAH were selected using the random forest model. The results showed that FMR1, RBM15, HNRNPA2B1 and IGFBP3 were upregulated in IPAH. In contrast, LRPPRC was downregulated. The single sample gene set enrichment analysis (ssGSEA) method was then adopted to estimate the immune microenvironment in distinct m6A clusters and m6A phenotype-related genes (PRGs) clusters, respectively. Furthermore, we calculated the m6A score via principal component analysis (PCA), and the Sankey diagram was selected to present the correlation among the m6A clusters, m6A PRGs clusters and m6A score. Finally, quantitative RT-PCR and Western blotting were used to validate the key genes in human pulmonary artery smooth muscle cells (HPASMCs) treated by human platelet-derived growth factor-BB (PDGF-BB). The relative mRNA and protein expression levels of FMR1 were significantly elevated, however, the relative mRNA and protein expression levels of LRPPRC were downregulated. Besides, the relative mRNA level of HNRNPA2B1 was increased. Generally, this bioinformatics analysis might provoke more insights into diagnosing and treating IPAH.
Predictive values of immune indicators on respiratory failure in the early phase of COVID-19 due to Delta and precedent variants
Authors: Nagaoka K. , Kawasuji H. , Takegoshi Y. , Murai Y. , Kaneda M. , Kimoto K. , Morimoto S. , Tani H. , Niimi H. , Morinaga Y. , Yamamoto Y.
Published: September 2023

Background

Immune response indicators in the early phase of COVID-19, including interferon and neutralizing responses against SARS-CoV-2, which predict hypoxemia remains unclear.

Methods

This prospective observational study recruited patients hospitalized with COVID-19 (before emergence of omicron variant). As the immune indicators, we assessed the serum levels of IFN-I/III, IL-6, CXCL10 and VEGF, using an ELISA at within 5 days after the onset of symptoms, and serum neutralizing responses using a pseudovirus assay. We also assessed SARS-CoV-2 viral load by qPCR using nasal-swab specimens and serum, to assess the association of indicators and viral distribution.

Results

The study enrolled 117 patients with COVID-19, of which 28 patients developed hypoxemia. None received vaccine before admission. Serum IFN-I levels (IFN-α and IFN-β), IL-6, CXCL10, LDH and CRP were significantly higher in patients who developed hypoxemia. A significant association with nasopharyngeal viral load was observed only for IFN-I. The serum levels of IFN-α, IL-6, CXCL10 were significantly associated with the presence of RNAemia. Multivariable analysis showed higher odds ratio of IFN-α, with cut-off value of 107 pg/ml, in regard to hypoxemia (Odds ratio [OR]=17.5; 95% confidence interval [CI], 4.7-85; p<0.001), compared to those of IL-6, >17.9 pg/ml (OR=10.5; 95% CI, 2.9-46; p<0.001).

Conclusions

This study demonstrated that serum IFN-α levels in the early phase of SARS-CoV-2 infection strongly predict hypoxemic respiratory failure in a manner different from that of the other indicators including IL-6 or humoral immune response, and instead sensitively reflect innate immune response against SARS-CoV-2 invasion.
Cost-effectiveness analysis of dostarlimab plus carboplatin-paclitaxel as first-line treatment for advanced endometrial cancer
Authors: You Maojin , Zeng Xiaoling , Zhang Jinrong , Huang Yufan , Zhang Yalan , Cai Zhongjie , Hu Yingying
Published: September 2023

Background

A recent phase III clinical trial (NCT03981796) evaluated the efficacy and safety of dostarlimab combined with carboplatin-paclitaxel (DOS-CP) compared to placebo combined with carboplatin-paclitaxel (PLB-CP) as a first-line treatment for advanced endometrial cancer (EC). The NCT03981796 trial demonstrated that DOS-CP significantly improved progression-free survival and overall survival of patients with advanced EC while maintaining an acceptable safety profile. However, DOS-CP is expensive and its cost-effectiveness has not been evaluated. This study aims to evaluate the cost-effectiveness of DOS-CP compared to PLB-CP as a first-line treatment for advanced EC from the perspective of the Chinese healthcare system.

Methods

A Markov model with three health states was developed to evaluate the cost-effectiveness of DOS-CP as a first-line treatment for advanced EC. Clinical efficacy data were derived from the NCT03981796 trial, and drug costs were determined based on national tender prices. Other costs and utility values were obtained from published literature. The outcomes assessed included total costs, quality-adjusted life years (QALYs), and incremental cost-effectiveness ratios (ICERs). The robustness of the model was assessed through one-way sensitivity analysis and probabilistic sensitivity analysis.

Results

In comparison to PLB-CP, the ICER of DOS-CP was $98,276.61/QALY for the overall population, $53,063.61/QALY for the dMMR subgroup, and $124,088.56/QALY for the pMMR subgroup. All of these ICER values were higher than the willingness-to-pay threshold of $38,201 per QALY. The most important variable that affected the results of the model was the discount rate, the cost of dostarlimab, and the utility value for progressive disease.

Conclusion

From the perspective of the Chinese healthcare system, DOS-CP is unlikely to be a cost-effective first-line treatment option for advanced EC.
The extraterritorial human rights obligations of Japan in regard to Fukushima nuclear contaminated water
Authors: Yu Liang , Xu Weizhuo
Published: September 2023

This article adopts a human rights approach to observe Japan’s policy on releasing nuclear contaminated water into the Pacific Ocean. It aims to provide a new discourse for stakeholders to push Japan to deal with Fukushima’s water in a responsible way. In doing so, it needs to elucidate an important normative question, namely whether a State has extraterritorial human rights obligations, given that international human rights law was traditionally perceived to deal with relationship between a State and its population. This stereotype would frustrate the world people to challenge the Japan’s decision based on human rights. In the era of economic globalization, however, there is an increasing need for the extraterritorial application of human rights treaties. Human rights theory and practice have gradually developed the jurisprudence on extraterritorial obligations of States based on an interpretation of jurisdiction. Such an approach has expanded from regulating State overseas military actions to tackling trans-boundary environmental harms. In the latter sense, the Fukushima incident is a good case, which urgently calls for a comprehensive examination of Japan’s extraterritorial human rights obligations. This article undertakes such a task by providing a logical interpretation of human rights treaty provisions. It is argued that the release of nuclear contaminated water entails a variety of extraterritorial obligations to respect, protect, and fulfill human rights on the part of Japan.
In vitro, in vivo and clinical studies comparing the efficacy of ceftazidime-avibactam monotherapy with ceftazidime-avibactam-containing combination regimens against carbapenem-resistant Enterobacterales and multidrug-resistant Pseudomonas aeruginosa isolates or infections: a scoping review
Authors: Aslan Abdullah Tarık , Ezure Yukiko , Horcajada Juan Pablo , Harris Patrick N. A. , Paterson David L.
Published: September 2023

Introduction

Carbapenem-resistant Enterobacterales (CRE) and multidrug-resistant Pseudomonas aeruginosa (MDR-PA) infections are associated with a high risk of morbidity, mortality, and treatment costs. We aimed to evaluate in vitro, in vivo and clinical studies comparing the efficacy of ceftazidime-avibactam (CZA) combination regimens with CZA alone against CRE and/or MDR-PA isolates or infections.

Methods

We systematically reviewed the relevant literature in CINAHL/MEDLINE, Pubmed, Cochrane, Web of Science, Embase, and Scopus until December 1, 2022. Review articles, grey literature, abstracts, comments, editorials, non-peer reviewed articles, non-English articles, and in vitro synergy studies conducted on single isolates were excluded.

Results

22 in vitro, 7 in vivo and 20 clinical studies were evaluated. In vitro studies showed reliable synergy between CZA and aztreonam against metallo-β-lactamase (MBL)-producing isolates. Some studies indicated good in vitro synergy between CZA and amikacin, meropenem, fosfomycin and polymyxins against CRE isolates. For MDR-PA isolates, there are comparatively fewer in vitro or in vivo studies. In observational clinical studies, mortality, clinical cure, adverse events, and development of CZA resistance after exposure were generally similar in monotherapy and combination therapy groups. However, antibiotic-related nephrotoxicity and infection relapses were higher in patients receiving CZA combination therapies.

Discussion

The benefit, if any, of CZA combination regimens in MDR-PA infections is elusive, as very few clinical studies have included these infections. There is no currently documented clinical benefit for the use of CZA combination regimens rather than CZA monotherapy. CZA combined with aztreonam for serious infections due to MBL producers should be evaluated by randomized controlled trials.

Systematic review registration

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=278552, CRD42021278552.
The efficacy and neural mechanism of acupuncture therapy in the treatment of visceral hypersensitivity in irritable bowel syndrome
Authors: Yang Yuanzhen , Wang Jiaqi , Zhang Chaoyang , Guo Yi , Zhao Meidan , Zhang Man , Li Zhongzheng , Gao Feifei , Luo Yu , Wang Yiru , Cao Junyi , Du Mingfang , Wang Yuzhe , Lin Xiaowei , Xu Zhifang
Published: September 2023

Irritable Bowel Syndrome (IBS) is a complex functional gastrointestinal disorder primarily characterized by chronic abdominal pain, bloating, and altered bowel habits. Chronic abdominal pain caused by visceral Hypersensitivity (VH) is the main reason why patients with IBS seek medication. Significant research effort has been devoted to the efficacy of acupuncture as a non-drug alternative therapy for visceral-hyperalgesia-induced IBS. Herein, we examined the central and peripheral analgesic mechanisms of acupuncture in IBS treatment. Acupuncture can improve inflammation and relieve pain by reducing 5-hydroxytryptamine and 5-HT3A receptor expression and increasing 5-HT4 receptor expression in peripheral intestinal sensory endings. Moreover, acupuncture can also activate the transient receptor potential vanillin 1 channel, block the activity of intestinal glial cells, and reduce the secretion of local pain-related neurotransmitters, thereby weakening peripheral sensitization. Moreover, by inhibiting the activation of N-methyl-D-aspartate receptor ion channels in the dorsal horn of the spinal cord and anterior cingulate cortex or releasing opioids, acupuncture can block excessive stimulation of abnormal pain signals in the brain and spinal cord. It can also stimulate glial cells (through the P2X7 and prokinetic protein pathways) to block VH pain perception and cognition. Furthermore, acupuncture can regulate the emotional components of IBS by targeting hypothalamic-pituitary-adrenal axis-related hormones and neurotransmitters via relevant brain nuclei, hence improving the IBS-induced VH response. These findings provide a scientific basis for acupuncture as an effective clinical adjuvant therapy for IBS pain.
Integration of natural and deep artificial cognitive models in medical images: BERT-based NER and relation extraction for electronic medical records
Authors: Guo Bo , Liu Huaming , Niu Lei
Published: September 2023

Introduction

Medical images and signals are important data sources in the medical field, and they contain key information such as patients' physiology, pathology, and genetics. However, due to the complexity and diversity of medical images and signals, resulting in difficulties in medical knowledge acquisition and decision support.

Methods

In order to solve this problem, this paper proposes an end-to-end framework based on BERT for NER and RE tasks in electronic medical records. Our framework first integrates NER and RE tasks into a unified model, adopting an end-to-end processing manner, which removes the limitation and error propagation of multiple independent steps in traditional methods. Second, by pre-training and fine-tuning the BERT model on large-scale electronic medical record data, we enable the model to obtain rich semantic representation capabilities that adapt to the needs of medical fields and tasks. Finally, through multi-task learning, we enable the model to make full use of the correlation and complementarity between NER and RE tasks, and improve the generalization ability and effect of the model on different data sets.

Results and discussion

We conduct experimental evaluation on four electronic medical record datasets, and the model significantly out performs other methods on different datasets in the NER task. In the RE task, the EMLB model also achieved advantages on different data sets, especially in the multi-task learning mode, its performance has been significantly improved, and the ETE and MTL modules performed well in terms of comprehensive precision and recall. Our research provides an innovative solution for medical image and signal data.
Diet associations in endometriosis: a critical narrative assessment with special reference to gluten
Authors: Brouns Fred , Van Haaps Annelotte , Keszthelyi Daniel , Venema Koen , Bongers Marlies , Maas Jacques , Mijatovic Velja
Published: September 2023

Endometriosis is characterized by the presence of endometrium-like tissue outside the uterus. The etiology remains largely unknown. Despite adequate treatment, patients can still experience symptoms or side effects resulting in therapy incompliance and in self-management strategies such as dietary measures is increasing. A gluten free diet is thought to be contributory in reducing endometriosis-related pain, thereby optimizing quality of life. However, data is conflicting and currently provides no evidence for causality. This narrative review aims to put the effect of dietary self-management strategies on endometriosis in a balanced perspective, especially the effect of gluten and a gluten free diet. Several studies have found a strong overlap in symptoms, metabolic and immune responses associated with endometriosis and those associated with celiac disease, ulcerative colitis, Crohn’s disease, irritable bowel syndrome and non-celiac wheat sensitivity. However, it remains unclear whether these diseases and/or disorders are causal to an increased risk of endometriosis. Some studies have found a positive effect on the risk of endometriosis, endometriosis-related symptoms and quality of life (QoL) when women either avoided certain nutrients or foods, or applied a specific nutrient supplementation. This includes the avoidance of red meat, an increasing intake of foods rich in anti-oxidants, omega-3, micronutrients and dietary fibers (e.g., fruit, vegetables) and the appliance of a gluten free diet. However, data from the available studies were generally graded of low quality and it was noted that placebo and/or nocebo effects influenced the reported positive effects. In addition, such effects were no longer seen when adjusting for confounders such as overweight, when a translation was made from in vitro to in vivo, or when the nutrients were not supplemented as isolated sources but as part of a mixed daily diet. Finally, some studies showed that long-term adherence to a gluten free diet is often associated with an impaired diet quality and nutrient intake, leading to negative health outcomes and reduced QoL. Concluding, scientific evidence on the efficacy of dietary interventions on well-defined clinical endpoints of endometriosis is lacking and recommending a gluten free diet to women solely diagnosed with endometriosis should therefore not be advised.
Photonic quantum chromodynamics
Authors: Saito Shinichi
Published: September 2023

Twisted photons with finite orbital angular momentum have a distinct mode profile with topological charge at the center of the mode while propagating in a certain direction. Each mode with different topological charges of m is orthogonal, in the sense that the overlap integral vanishes among modes with different values of m. Here, we theoretically consider a superposition state among three different modes with left and right vortices and a Gaussian mode without a vortex. These three states are considered to be assigned to different quantum states; thus, we employed the su(3) Lie algebra and the associated SU(3) Lie group to classify the photonic states. We calculated expectation values of eight generators of the su(3) Lie algebra, which should be observable, since the generators are Hermite matrices. We proposed to call these parameters Gell-Mann parameters, named after the theoretical physicist Murray Gell-Mann, who established quantum chromodynamics (QCD) for quarks. The Gell-Mann parameters are represented on the eight-dimensional hypersphere with its radius fixed due to the conservation law of the Casimir operator. Thus, we discussed a possibility of exploring photonic QCD in experiments and classified SU(3) states to embed the parameters in SO(6) and SO(5).
Development of genomic resources for Rhodes grass (Chloris gayana), draft genome and annotated variant discovery
Authors: Maybery-Reupert Kellie , Isenegger Daniel , Hayden Matthew , Cogan Noel
Published: September 2023

Genomic resources for grasses, especially warm-season grasses are limited despite their commercial and environmental importance. Here, we report the first annotated draft whole genome sequence for diploid Rhodes grass (Chloris gayana), a tropical C4 species. Generated using long read nanopore sequencing and assembled using the Flye software package, the assembled genome is 603 Mbp in size and comprises 5,233 fragments that were annotated using the GenSas pipeline. The annotated genome has 46,087 predicted genes corresponding to 92.0% of the expected genomic content present via BUSCO analysis. Gene ontology terms and repetitive elements are identified and discussed. An additional 94 individual plant genotypes originating from three diploid and two tetraploid Rhodes grass cultivars were short-read whole genome resequenced (WGR) to generate a single nucleotide polymorphism (SNP) resource for the species that can be used to elucidate inter- and intra-cultivar relationships across both ploidy levels. A total of 75,777 high quality SNPs were used to generate a phylogenetic tree, highlighting the diversity present within the cultivars which agreed with the known breeding history. Differentiation was observed between diploid and tetraploid cultivars. The WGR data were also used to provide insights into the nature and evolution of the tetraploid status of the species, with results largely agreeing with the published literature that the tetraploids are autotetraploid.
Disentangling racing thoughts from mind wandering in adult attention deficit hyperactivity disorder
Authors: Martz Emilie , Weiner Luisa , Bonnefond Anne , Weibel Sébastien
Published: September 2023

Introduction

Mental restlessness reported by adult with Attention Deficit Hyperactivity Disorder (ADHD) has been mainly explained by excessive mind wandering. However, the description of a mind constantly on the go is also akin to racing thoughts, predominantly described in bipolar disorder. This paper aimed at disentangling mind wandering from racing thoughts in adult with ADHD. Associations between those mental phenomena and the ADHD symptomatology were also investigated.

Methods

To this aim, 84 adults with ADHD completed self-reported questionnaires, including the Mind Wandering-Deliberate and Mind Wandering-Spontaneous questionnaires, the Racing and Crowded Thoughts Questionnaire and the Daydreaming Frequency Scale. Factorial analysis and multiple linear regressions were performed.

Results

The factor analysis yielded a two-factor solution. The first factor encompassed the three facets of racing thoughts and was predicted by emotional lability. The second comprised deliberated-MW, spontaneous-MW and daydreaming, but was neither related to the ADHD symptoms, nor functional impairment.

Discussion

These findings suggest that MW and racing thoughts are two distinguishable mental phenomena. Racing thoughts appear to be a relevant hypothesis to explain the mental restlessness in adult ADHD.
Modeling unit non-response and validity of online teaching evaluation in higher education using generalizability theory approach
Authors: Dzakadzie Yayra , Quansah Frank
Published: September 2023

Introduction

Unit non-response is a common phenomenon in online teaching evaluation in higher education institutions. However, little is known about the relationship between the rates of unit non-response and the quality of online teaching evaluation exercise. This study explored the incidence of unit non-response and how this phenomenon relates to the reliability of students’ responses to online teaching evaluation.

Methods

Adopting the generalizability theory approach, students’ evaluation of teaching data from a university in Ghana was analyzed by conducting both generalizability study (G-study)- and decision study (D-study) analyses.

Results

The results revealed that unit non-response among students was predominant in online teaching evaluation exercise. The study demonstrated that higher rates of non-response among students were associated with high levels of measurement errors and low reliability of responses.

Discussion

The findings of this study have implications for the accuracy of online evaluation data obtained for decision-making in higher education contexts. The study calls on higher education administrators to embark on sensitization and awareness campaigns that target students on the need to actively participate in the appraisal of teaching at the university to address the issue of unit non-response.
Cross-cultural metathemes of Chinese and Japanese university students' perspective on parental care
Authors: Peng Xuxin , Nakatani Hisae , Chen Huifang , Inoue Yuriko , Song Fang , Yoshihara Mikako , Lei Ruxin
Published: September 2023

Introduction

Due to declining birthrates and aging populations, parental care is going to place a greater burden on younger generations in the future, especially in East Asia where it is more common for children to provide care regardless of whether there is a national long-term care insurance program. Therefore, it has become important to understand the younger generation's views on parental care.

Methods

An explorative, metathematic qualitative study design was used. Data collection relied on semi-structured interviews, of which 19 Chinese and 19 Japanese university students were conducted from December 2021 to July 2022 using a snowball sampling method. Metatheme analysis was then used to identify broad cross-cultural metathemes and inter-relationships on parental care.

Results

Three parental care metathemes were identified for the perspectives of parental care: distrust of leaving parental care to others, responsibility to care for their parents, and importance of parent-child interactions about parental care.

Conclusion

To improve social support for care, both countries must improve long-term care service delivery and healthcare systems and ensure that there is a trusting relationship between healthcare professionals and the public. Governments should also ensure that adult children receive assistance to balance their work, life, and parental care responsibilities. The findings provide several practical suggestions for improving healthcare systems in China and Japan through the younger generations' views.
Stress experiences of healthcare assistants in family practice at the onset of the COVID-19 pandemic: a mixed methods study
Authors: Schrader Hanna , Ruck Jessica , Borgulya Gábor , Parisi Sandra , Ehlers-Mondorf Jana , Kaduszkiewicz Hanna , Joos Stefanie , Grau Anna , Linde Klaus , Gágyor Ildikó
Published: September 2023

Background

At the beginning of the pandemic in 2020, healthcare assistants in general practices were confronted with numerous new challenges. The aim of the study was to investigate the stress factors of healthcare assistants in March/April 2020 as well as in the further course of the pandemic in 2020.

Methods

From August to December 2020, 6,300 randomly selected healthcare assistants in four German states were invited to participate in the study. We performed a mixed methods design using semi-structured telephone interviews and a cross-sectional survey with quantitative and open questions. The feeling of psychological burden was assessed on a 6-point likert-scale. We defined stress factors and categorized them in patient, non-patient and organizational stress factors. The results of the three data sets were compared within a triangulation protocol.

Results

One thousand two hundred seventy-four surveys were analyzed and 28 interviews with 34 healthcare assistants were conducted. Of the participants, 29.5% reported experiences of a very high or high feeling of psychological burden in March/April 2020. Worries about the patients’ health and an uncertainty around the new disease were among the patient-related stress factors. Non-patient-related stress factors were problems with the compatibility of work and family, and the fear of infecting relatives with COVID-19. Organizational efforts and dissatisfaction with governmental pandemic management were reported as organizational stress factors. Support from the employer and team cohesion were considered as important resources.

Discussion

It is necessary to reduce stress among healthcare assistants by improving their working conditions and to strengthen their resilience to ensure primary healthcare delivery in future health crises.