bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS PERSONAL HYGIENE DAN KONDISI SANITASI NARAPIDANA PADA LAPAS KLAS IIB CIANJUR
Authors: Raka Irman
Published: November 2023

A healthy environment is an ecological balance that must exist between humans and the environment in order to guarantee a healthy condition of humans. This study aims to determine how the state of personal hygiene and sanitary conditions contained in Cianjur Class II Prison. This research was conducted in the form of qualitative research with phenomenological approach, namely by conducting interviews with 10 informants, where 2 main informants were interviewing the polyclinic and casibinadik health workers. The research was conducted from 29 January to 25 February 2020 in Lapas IIB Cianjur. The results of the study showed the results of the analysis related to personal hygiene conditions and sanitary conditions of prisoners in Prison Class IIB Cianjur can be concluded that in terms of personal hygiene in each individual prisoner is already good in hand and nail hygiene, cleanliness of clothes, towels and cleanliness of his bed. And in terms of sanitation, clean water, rubbish and latrines are good enough and cleanliness is always maintained by them by organizing a daily picket system in maintaining the cleanliness of the rooms in each block. The author suggests to Cianjur Class IIB Lapas officers to further increase supervision on each supervision of cleanliness in each block, and conduct health education for personal hygiene and sanitation environment sanitation to increase awareness of prisoners that hygiene must always be maintained so that they are not susceptible to disease.
HUBUNGAN KOGNITIF DENGAN KEMANDIRIAN ACTIVITY OF DAILY LIVING PADA PASIEN SKIZOFRENIA
Authors: Untari Rita , Muhammad Ilham Akbar Maghribi
Published: November 2023

Background. Schizophrenia usually has a problem with the function of cognitive function deficits which can affect work activities in daily life. This research aims to determine whether individuals with good cognitive level have more independence in daily activities or vice versa. This research was conducted in RSJ dr. Radjiman Wediodiningrat Lawang with a sample of 50 respondents. To measure the cognitive level used the  Allen Cognitive Levels Skills (ACLS) instrument. Then, to measure the independence of  Activity of Daily Living (ADL) used Kohlman Evaluating Livings Skills (KELS) instrument. This research aims to determine whether there is a relationship between cognitive level with the independence of daily living activities in schizophrenic patients.

Research methods. The design of this research is non experimental quantitative with cross sectional approach and by using Pearson Product Moment correlation data analysis technique through SPPS 16 for windows.

Research result. From the result of hypothesis testing Pearson Product Moment Correlation known level of significance (2 tailed) is -0,838 (< 0,05).

Conclusion. This research shows that there is relationship between cognitive levels with independence of  Activity of Daily Living in schizophrenia patients in RSJ dr. Radjiman Wediodiningrat Lawang.

 

Keywords : cognitive levels, activity of daily living, schizophrenia.
HUBUNGAN ANTARA PERSEPSI REMAJA TENTANG MEROKOK DENGAN PERILAKU MEROKOK REMAJA Di KARANG TARUNA DUKUH NGRINGIN BANGSRI KARANGPANDAN
Authors: Mutik mahmudah Mutik , Triana Mirasari
Published: November 2023

Smoking is a habit that is found in everyday life. Lifestyle or life style is interesting as a health problem, minimally considered a risk factor for a non-communicable disease. The study shows that heavy smokers have started this habit since their teens, and almost no heavy smokers who just started smoking as an adult. For this reason, adolescence is often considered a critical period that determines whether we become smokers or not (Addianti, 2012). Research used by researchers is quantitative research to find out the relationship between teenage perceptions about smoking and smoking behavior in Karangtaruna teenagers in Hamlet Ngringin Bangsri Karaangpandan. October 2018 to February 2019 with 36 respondents. The results found there is a relationship between adolescent perceptions about smoking with smoking behavior, it is expected adolescents in particular to further enhance better perceptions about smoking so that good behavior will increase.

 

Merokok merupakan salah satu kebiasaan yang ditemui dalam kehidupan sehari-hari. Gaya hidup atau life style ini menarik sebagai suatu masalah kesehatan, minimal dianggap sebagai faktor risiko dari suatu penyakit tidak menular. Hasil studi menunjukkan bahwa perokok berat telah memulai kebiasaannya ini sejak berusia belasan tahun, dan hampir tidak ada perokok berat yang baru memulai merokok pada saat dewasa. Karena itulah, masa remaja sering kali dianggap masa kritis yang menentukan apakah nantinya kita menjadi perokok atau bukan (Addianti,2012). Penelitian yang digunakan peneliti adalah penelitian kuantitatif untuk menegtahui hubungan natara persepsi remaja tentang merokok dengan perilaku merokok pada remaja karangtaruna di Dukuh Ngringin Bangsri Karaangpandan. Oktober  2018 sampai dengan Februari  2019 dengan responden sebayak 36 orang. Hasil penelitian didapatkan ada hubungan antara persepsi remaja tentang merokok dengan perilaku merokok, diharapkan remaja khususnya untuk lebih meningkatkan persepsi yang lebih baik tentang merokok sehingga perilaku yang baik akan meningkat.
DETEKSI DINI DAYA TAHAN JANTUNG PARU PADA MAHASISWA
Authors: Amalia Solichati Rizqi1  , Yudha Wahyu Putra
Published: November 2023

Abstrak

Daya tahan jantung paru merupakan  kemampuan system pernapasan dan sirkulasinya di dalam tubuh untuk mensuplai bahan bakar selama melakukan aktivitas fisik. Daya tahan jantung paru menunjukkan tingkat kebuagaran seseorang.  Metode penelitian ini adalah penelitian disckrptif analitik yaitu  menggambarkan kondisi daya tahan jantung paru mahasiswa dengan penilaian daya tahan jantung paru dengan menggunakan MFT ( Multisata Fitness Test).  Tujuan penelian ini adalah untuk mengetahui kondisi data tahan jantung paru mahasiswa dengan kategori usia 16 – 18 tahun dan 19 – 21 tahun serta berdasarkan kategori usia.  Hasil dalam penelitian ini menunjukkan bahwa nilai daya tahan jantung paru untuk kategori usi 16 – 18 tahun dan 19 – 21 tahun adalah cukup, untuk jenis kelamin laki – laki dan perempuan adalah cukup

 

Abstract Cardiovascular endurance is the ability of the respiratory system and circulation in the body to supply fuel during physical activity. Heart-lung endurance shows a person's level of fitness. The method of this research is analytic descriptive research, which describes the condition of the cardiac endurance of students by assessing the cardiovascular endurance using MFT (Multisata Fitness Test). The purpose of this study was to determine the condition of cardiac and pulmonary resistance data of students with the age category of 16-18 years and 19-21 years and based on age categories. The results in this study indicate that the cardiac and pulmonary endurance scores for the age category 16-18 years and 19-21 years are sufficient, for male and female sex is sufficient.
ANALISIS PELAPORAN PENCAPAIAN TARGET PELATIHAN INTERNAL PEGAWAI: STUDI KASUS DI RUMAH SAKIT UMUM HAJI SURABAYA
Authors: Nadiya Ulyafasya Rohmani  , Agus Aan Adriansyah  , Listiana Dewi
Published: November 2023

Di era globalisasi saat ini, dengan berkembangnya zaman persaingan antar Rumah Sakit atau Perusahaan semakin ketat, sehingga sumber daya manusia dituntut untuk mengembangkan dirinya, yaitu salah satunya melalui pelatihan. Target yang harus dicapai pegawai dalam keikut sertaan pelatihan internal yaitu sebesar 70% per tahunnya. Pada umumnya, hasil yang diinginkan dari program pelatihan yaitu penguasaan atau meningkatkan keterampilan pegawai peserta program pelatihan. Tujuan penelitian ini yaitu untuk mengidentifikasi serta menganalisis hasil pencapaian target keikut sertaan pelatihan internal di Rumah Sakit Umum Haji Surabaya. Metode yang digunakan dalam penelitian ini adalah metode kualitatif dengan pendekatan cross sectional. Populasi dalam penelitian ini yaitu 1.196 pegawai dengan sampel yang diwawancarai yaitu 5 pegawai. Teknik pengumpulan data menggunakan data primer yang diperoleh melalui wawancara mendalam, observasi dan data sekunder yang diperoleh dari dokumen Rumah Sakit. Wawancara dilakukan dengan seorang informan, yaitu koordinator pelatihan internal serta coordinator bagian DIKLAT. Hasil dari penelitian ini menunjukkan bahwa pegawai yang mendapatkan pelatihan 711 pegawai dari 1.196 pegawai. Maka dapat diketahui bahwa belum tercapainya target pelatihan internal di Rumah Sakit Haji Surabaya. Hal ini disebabkan oleh beberapa faktor yaitu partisipasi pegawai, motivasi pegawai, keterlambatan dalam mengumpulkan laporan. Akibat dari kurangnya partisipasi pegawai yaitu salah satunya akan menurunnya kompetensi pegawai Rumah Sakit dan akan menyebabkan menurunnya kualitas Rumah Sakit tersebut. Saran pada penelitian ini yaitu memberikan keyakinan dalam menjalankan pekerjaannya dengan memberikan motivasi kepada pegawainya agar dapat mengembangkan kemampuan dan rasa percaya diri.
KONTROL STABILITAS LUMBAL DENGAN BIRD DOG EXERCISE UNTUK MENCEGAH KEJADIAN CEDERA EKSTREMITAS BAWAH OLAHRAGA SURFING PADA WISATAWAN
Authors: Ni Nyoman Wahyuni  , I Made Niko Winaya  , Ni Luh Putu Gita Karunia Saraswati  , Made Hendra Satria Nugraha
Published: November 2023

Abstrak

Surfing menjadi sebuah olahraga yang diminati banyak orang termasuk wisatawan. Surfing sendiri memiliki risiko cedera seperti olahraga pada umumnya. Cedera pada olahraga surfing banyak terjadi pada ekstremitas bawah karena berbagai faktor. Maka dari itu, perlu adanya penguatan otot tertentu untuk menjaga stabilitas guna mencegah cedera pada ekstremitas bawah. Tujuan penulisan review ini adalah untuk mengetahui apakah dengan kontrol stabilitas lumbal dengan bird dog exercise dapat mencegah kejadian cedera pada ekstremitas bawah olahraga surfing pada wisatawan. Metode yang digunakan adalah tinjauan pustaka yang disusun dengan menggunakan data sekunder berupa jurnal penelitian yang berkaitan dengan keseimbangan lumbal, mencegah kejadian cedera, eksktremitas bawah, olahraga surfing, dan wisatawan yang didapatkan melalui Google Schoolar dan PubMed. Penurunan angka cedera ekstremitas bawah pada peselancar dapat dicegah dengan melakukan sebuah latihan untuk stabilitas lumbal. Latihan yang paling penting untuk mejaga stabilitas lumbal adalah stabilitas core. Latihan stabilitas core seperti bird dig exercise dapat menguatkan otot hingga ke bagian deep layer, khususnya erector spine dan multifidus. Berdasarkan kajian pustaka yang dilakukan, maka dapat disimpulkan bahwa kontrol stabilitas lumbal dengan bird dog exercise dapat mencegah kejadian cedera pada ekstremitas bawah olahraga surfing pada wisatawan.
HUBUNGAN KELENGKAPAN LAPORAN OPERASI PASIEN DENGAN KEAKURATAN KODE KASUS PATAH TULANG DI RUMAH SAKIT PANTI WALUYA SAWAHAN MALANG
Authors: Vincensia Dea  , Romaden Marbun  , Rea Ariyanti
Published: November 2023

Lembar laporan operasi salah satu bagian dari berkas rekam medis, mempunyai kegunaan yang sangat luas, karena tidak hanya menyangkut antara pasien dengan pemberian pelayanan kesehatan saja. Kelengkapan dokumen rekam medis dibutuhkan pada pelayanan di rumah sakit. Terutama kasus yang beresiko seperti tindakan-tindakan invasif di ruang bedah.  Karena kasus bedah merupakan kasus beresiko tinggi maka akan dibutuhkan data yang lengkap agar tidak terjadi hal-hal yang tidak diinginkan misalnya kasus malpraktik yang bisa masuk ke ranah hukum. Desain penelitian yang digunakan dalam penelitian ini adalah penelitian observasional analitik dengan studi korelasi yaitu mencari hubungan antara satu keadaan dengan keadaan lain yang terdapat dalam satu populasi yang sama. Penelitian ini menggunakan data sekunder yang diperoleh dari dokumen rekam medis pasien bedah yang berkunjung pada Januari 2020 - Desember 2020. Sampel penelitian ini berjumlah 82 sampel berkas rekam medis pasien kasus operasi patah tulang. Instrumen Penelitian yang digunakan adalah menggunakan lembar check-list yang telah disusun. Analisis data menggunakan uji normalitas menggunakan uji Kolmogorov Smirnov dan Analisa Korelasi Rank Spearman. Pada penelitian ini diperoleh bahwa kelengkpaan laporan operasi dengan kategori lengkap sejumlah 14 berkas, kategori cukup lengkap sejumlah 50 berkas dan kategori tidak lengkap sejumlah 18 berkas. Sedangkan keakuratan kode kasus patah tulang dengan kategori akurat sejumlah 17 kode, kategori cukup akurat sejumlah 55 kode dan kategori tidak akurat sejumlah 10 kode. Dari hasil uji analisa korelasi Rank Spearman dapat diketahui bahwa nilai sig (p) adalah sebesar 0,003 sehingga nilai sig (p) < 0,05. Dari hasil tersebut menjelaskan bahwa ada hubungan antara kelengkapan laporan operasi pasien dengan keakuratan kode kasus patah tulang di Rumah Sakit Panti Waluya Sawahan (RKZ) Malang.
HIPERTENSI DALAM KEHAMILAN PADA IBU HAMIL TRIMESTER 3 DI RUMAH SAKIT IBU DAN ANAK CINTA KASIH TAHUN 2021
Authors: Shofi Jasmine  , Ira Marti Ayu  , Gisely Vionalita  , Intan Silviana
Published: November 2023

Hipertensi dalam kehamilan adalah tekanan darah ibu hamil yang tinggi sistolik >140 mmHg dan diastolik >90 mmHg atau protein urin positif. Menurut world health organization (WHO) sekitar 28% dari angka kematian ibu (AKI) disebabkan hipertensi dalam kehamilan. Berdasarkan profil kesehatan Indonesia tahun 2016 diketahui bahwa hipertensi 27,1% adalah presentasi tertinggi kedua. Masalah di tempat penelitian  berdasarkan data antenatal care (ANC) Rumah Sakit Ibu dan Anak Cinta Kasih Tahun 2019 sebanyak 100 orang (47,6%) ibu hamil dengan hipertensi dalam kehamilan, tahun 2020 sebanyak 100 orang (38,4%) ibu hamil dengan hipertensi dalam kehamilan dan tahun 2021 sebanyak 150 orang (49,6%).Tujuan dari penelitian ini yaitu untuk mengetahui faktor-faktor yang mempengaruhi hipertensi dalam kehamilan di Rumah Sakit Ibu dan Anak Cinta Kasih tahun 2021. Jenis penelitian kuantitatif dengan desain penelitian cross sectional. Populasi seluruh ibu hamil trimester 3 dan sampel yang digunakan sebanyak 125 ibu hamil dengan teknik pengambilan sampel simple random sampling. Data dianalisis dengan analisis univariat dan analisis bivariat dengan uji chi square. Hasil univariat menunjukan proporsi tertinggi yaitu hipertensi dalam kehamilan (78,4%), gravida ibu hamil (69,6%), umur ibu hamil (63,2%), riwayat hipertensi sebelum kehamilan (59,2%). Hasil bivariat menunjukan tidak terdapat hubungan antara gravida dengan hipertensi dalam kehamilan (PR= 0,96 dan 95% CI (0,78-1,18)).Penelitian ini juga menemukan ada hubungan antara umur ibu (PR= 1,23 dan 95% CI (1,04-1,46)),riwayat kehamilan (PR=1,23 dan 95% CI (1,03-1,46) dengan hipertensi dalam kehamilan.
Hubungan Pola Makan dan Pola Aktivitas Dengan Pengendalian Kadar Asam Urat Penderita Hiperurisemia
Authors: Saifudin Zukhri  , Devi Permatasari
Published: November 2023

Kadar asam urat yang tidak terkendali pada penderita hiperurisemia dapat menimbulkan komplikasi serius. Pola aktivitas dan pola makan merupakan sebagian dari banyak faktor yang berpengaruh terhadap kadar asam urat. Penelitian ini bertujuan untuk mengetahui hubungan antara pola aktivitas dan pola makan dengan pengendalian kadar asam urat pada penderita hiperurisemia di Klaten. Penelitian ini menggunakan disain observasional dengan pendekatan crosssectional. Sampel penelitian adalah 58 orang penderita hiperurisemia, 18 tahun atau lebih yang diambil dari 8 Desa di Kecamatan Klaten Utara, pada periode Januari – Desember 2021. Tingkat aktivitas diukur menggunakan Global Physical Activity Questionnaire (GPAQ), pola makan diukur dengan Food Frequency Quetionaire(FFQ). Kadar asam urat diperiksa menggunakan sampel darah tepi menggunakan alat merk Easy Touchc. Analisis biavriat menggunakan Chi square (X2). Hasil penelitian menunjukkan bahwa 67,2 % responden perempuan, 62% memiliki pola makan yang baik, 50 % memilki tingkat aktivitas tinggi ( MET≥3000), dan 67,2 % kadar asam urat terkontrol (< 7 mg/dl). Uji Chi square menunjukkan adanya hubungan yang signifikan antara pola makan (p=0.014) dan pola aktivitas (p=0.041) dengan kadar asam urat. Pola makan dan pola aktivitas berhubungan secara signifikan dengan pengendalian kadar asam urat penderita hiperurisemia. Penelitian lanjutan dengan mengendalikan variabel pengganggu perlu dilakukan.
TINGKAT KEBUGARAN JASMANI PADA IBU HAMIL TRIMESTER III DI PUSKESMAS GAJAHAN KOTA SURAKARTA
Authors: Vitri Dyah Herawati  , Atik Aryani
Published: November 2023

Ibu hamil dengan kehamilan terutama pada trimester III memerlukan upaya pemeliharaan dan peningkatan kesehatan serta perhatian ekstra sehingga kondisi kesehatan tetap terjaga. Latihan berjalan kaki secara teratur dapat meningkatkan kebugaran, kondisi kekuatan otot-otot dan persendian yang berperan dalam mekanisme persalinan, sehingga dapat mempercepat persalinan kala II. Penelitian ini bertujuan untuk mengetahui tingkat kebugaran jasmani pada ibu hamil trimester III di Puskesmas Gajahan Surakarta. Penelitian ini menggunakan pendekatan kuantitatif, jenis penelitian yang digunakan adalah deskriptif korelasi dengan desain cross sectional. Sampel sebanyak 69 ibu hamil trimester III. Teknik pengambilan sampel menggunakan purposive sampling. Instrumen pengukuran kebugaran jasmani dengan mengukur nadi menggunakan test Havard. Data penelitian diuji menggunakan Kendall tau. Hasi Penelitian menunjukkan Sebanyak 12 responden (17,4%) mempunyai kebugaran jasmani yang baik, 29 responden (42%) dengan kebugaran jasmani cukup, 28 responden (40,6%) dengan kebugaran jasmani kurang sebanyak 42 responden (60,9%). Hasil uji Kendall tau diperoleh nilai r = 0,281 dengan p-value = 0,0001. Tingkat kebugaran jasmani pada ibu hamil trimester III di Puskesmas Gajahan Kota Surakarta sebagian dalam kategori cukup (42%).
Identifikasi Kepuasan Keluarga Pasien Berdasarkan Respon Time Di Instalasi Gawat Darurat Rumah Sakit Jiwa Daerah Surakarta
Authors: Atik Aryani  , Vitri Dyah Herawati  , Ngadimin
Published: November 2023

Pelayanan keperawatan gawat darurat meliputi pelayanan yang ditujukan kepada pasien jiwa dengan tingkat keparahan masalah kesehatan mental. Respon time triage perawat dalam menangani keparahan pasien jiwa akan berpengaruh terhadap kepuasan keluarga pasien. Semakin cepat respon time triage perawat dalam menangani keparahan pasien jiwa maka kepuasan keluarga pasien dalam menerima layanan semakin tinggi. Tujuan penelitian ini untuk mengidentifikasi kepuasan keluarga pasien berdasarkan respon time di ruang instalasi gawat darurat. Penelitian ini merupakan penelitian deskriptif kuantitatif. Sampel dalam penelitian ini adalah keluarga pasien gangguan jiwa di ruang Instalasi Gawat Darurat Rumah Sakit Jiwa Daerah Surakarta. Adapun jumlah responden dalam penelitian sebanyak 79 orang. Teknik pengambilan sampling menggunakan metode purposive sampling. Pengumpulan data menggunakan kuesioner. Hasil penelitian kepuasan keluarga pasien menunjukkan distribusi tertinggi dalam kategori puas sebanyak 57 responden (72,1%). Dan hanya 3 responden (3,8%) yang menyatakan ketidakpuasan terhadap respon time di ruang Instalasi Gawat Darurat. Simpulan penelitian adalah keluarga pasien menyatakan pelayanan petugas kesehatan dalam bentuk respon time sebagian besar dalam kategori memuaskan yang dilihat dari aspek Responsiveness, Assurance, Tangible, Empaty, dan Reliability
The Holocene vegetational development of Tugtuligssuaq and Qeqertat, Northwest Greenland
Authors: Fredskild Bent
Published: November 2023

Holocene pollen- and macrofossil diagrams from three high arctic lakes in Northwest Greenland are presented, and based on these the radiocarbon dated palaeovegetation zones (PY zones) are described. Two of the lakes are situated above the upper marine limit on the peninsula Tugtuligssuaq in Melville Bugt, in a highly maritime climate. The vegetation, invading the deglaciated soil around 8500 B.P., was a speciesrich pioneer vegetation , dominated by Poaceae, Oxyria digyna and other herbs, including some species not growing on the peninsula today. The first dwarf-shrubs, Empetrum hermaphroditum and Vaccinium uliginosum, immigrated in the coming centuries, followed by Cassiope tetragona. By 6700 B.P. Salix arctica and S. herbacea immigrated. These species together with Cyperaceae, later on Cassiope, dominate the pollen spectra until c. 2300 B.P. The influx of long-distance pollen, indicating more frequent south-westerly winds, increased around 5000 B.P. and remained at a high level until a marked decrease is seen c. 2300 B.P. Since then the influx was very low. Cassiope dominates in the recent PV zone. The lakes were fairly rich in the first millennia with high production of Pediastrum and Botryococcus. Colymbetes dolabratus and Gasterosteus aculeatus, both north of their present distribution limit , lived in the lakes at an early stage.
Qeqertat at the head of Inglefield Bredning has a more continental climate. The cored lake was not isolated from the sea until 6800 B.P., just prior to the immigration of Salix arctica. Cyperaceae dominate the pollen diagram until around 3500 B.P. when Cassiope and especially Salix arctica become more frequent. At the same time marked changes in the microflora in the lake indicate increased frost boil activity around the lake as a result of a climatic change. Open soil plants are more frequent in the present PY zone.
Pollen influx is low in these high arctic lakes, viz. c. 6 in the recent PY zone in Langesø and c. 1 in the Qeqertat lake. Melt water washes down pollen and other plant material from the surrounding slopes into Rundesø, thus causing too high influx values.
The arthropod trail Multipodichnus from the upper Middle Cambrian (Holm Dal Formation) of central North Greenland
Authors: Bergström Jan , Ineson J. R.
Published: November 2023

A Cruziana-like trace fossil is described from the uppermost beds of the Holm Dal Formation in its type locality in western Peary Land. Lower stratigraphic levels within the same formation yield rich faunas of late Middle Cambrian age. The trace has its closest known counterparts in freshwater deposits from the Permian and Triassic.
Fauna and flora
Authors: Feyling-Hanssen R.W. , Funder S.
Published: November 2023

No abstract
Ion adsorption-type rare earth element deposits in western Peninsular Malaysia: A case study in Bukit Enggang Granite, Kedah
Authors:   Department of Mineral and Geoscience Kedah/Perlis/P. Pinang, Jln. Perak, Off Jalan Putra, 05150 Alor Setar, Kedah, Malaysia, Fauzi Fakhruddin Afif , James Edwin ,   Sabah Mineral Management, Block D, Unit 23A & 23, 5th Floor, Phase 1 KK Times Square, 88100 K. Kinabalu, Sabah, Malaysia, Musa Muhammad Sufi ,   Technical Service Division, Department of Mineral and Geoscience Malaysia, Jln Sultan Azlan Shah, 31400 Ipoh, Perak, Malaysia, Ariffin Hamdan ,   Department of Mineral and Geoscience Kedah/Perlis/P. Pinang, Jln. Perak, Off Jalan Putra, 05150 Alor Setar, Kedah, Malaysia, Sulaiman Abdullah ,   Department of Mineral and Geoscience Malaysia HQ, Level 9, Menara PjH, Jln Tun Abdul Razak, Precint 2, 62100 Putrajaya, Malaysi, Sibon Mahat ,   Department of Mineral and Geoscience Perak, Jln Sultan Azlan Shah, 31400 Ipoh, Perak, Malaysia, Abdul Rahman Abdul Hadi ,   Department of Mineral and Geoscience Selangor/W. Persekutuan, Level 6 & 7, Bangunan Darul Ehsan, Seksyen 14, 40000 Shah Alam, Selangor, Malaysia, Zahri Muhammad Falah ,   Technical Service Division, Department of Mineral and Geoscience Malaysia, Jln Sultan Azlan Shah, 31400 Ipoh, Perak, Malaysia, Ali Azizan ,   Department of Mineral and Geoscience Kedah/Perlis/P. Pinang, Jln. Perak, Off Jalan Putra, 05150 Alor Setar, Kedah, Malaysia
Published: November 2023

This paper reports on the rare earth element (REE) deposit in Bukit Enggang Granite in Sik, Kedah, and its enrichment patterns. The granitic rock in the study area is porphyritic biotite granite with K-feldspar, quartz and biotite as the main minerals, with randomly arranged K-feldspar phenocrysts. The average REE content in rock samples is 340.9 ppm. The exposed weathered profiles are between 3 to 7 meters in thickness. The C horizon is thicker than the B horizon. The average REE content in soil samples taken from the weathered profiles is 943.9 ppm. Interpretations from laboratory results reveal that the REE deposit in the study area is of the ion adsorption-type, with the REE enrichment in the weathered profiles originating from easily weathered REE bearing minerals in the parent rock, rather than highly resistant minerals like monazite, xenotime and zircon.
Bridging hope: South Africa’s ECMO reporting journey begins
Authors: Calligaro G , Thomson D
Published: November 2023

-
The hidden epidemic of post-tuberculosis bronchiectasis
Authors: Perumal R
Published: November 2023

-
Extracorporeal membrane oxygenation in South Africa: Experience from a single centre in the private sector
Authors: Van Zijl N , Janson J T , Sussman M , Geldenhuys A
Published: November 2023

Background. Extracorporeal membrane oxygenation (ECMO) is an advanced, resource-intensive technology used in a limited capacity in South Africa (SA). Minimal data on the use of ECMO in SA are available.
Objectives. To describe the indications, early outcome and comorbidities of patients placed on ECMO in the highest-volume ECMO centre in SA.
Methods. We performed a single-centre retrospective review of all adult patients supported with any form of ECMO from August 2016 to December 2018. Operative and clinical records were reviewed. The primary objective of this study was to review the outcome of patients placed on ECMO in the form of survival to hospital discharge. The secondary objectives were to identify population-specific comorbidities and indications for ECMO that could be associated with non-survival and to compare outcome with known risk scores in the form of the Respiratory ECMO Survival Prediction (RESP) and Survival After Venoarterial ECMO (SAVE) scores.
Results. One hundred and seven patients were identified. The primary indication for ECMO was respiratory support in 78 patients and cardiac support in 29 patients. Forty-seven patients were discharged from hospital, with a 44.0% overall survival rate. Gender (p=0.039), age (p=0.019) and hypertension (p=0.022) were associated with death in univariate logistic regression analysis. However, after adjusting for potential confounding in multivariate logistic regression analysis, the association was no longer significant. In the all respiratory support group, patients in risk class IV had better than predicted survival according to the RESP score, while risk classes I, II and III had worse than predicted survival. In the circulatory support group, all risk classes had worse than predicted survival according to the SAVE score.
Conclusion. We report ECMO outcomes in SA for the first time. We identified very high mortality rates for patients transferred on ECMO from other facilities and for patients converted from venovenous ECMO to venoarterial ECMO. Although our outcomes were comparable in some of the risk classes, further external validation of the SAVE and RESP scores will be needed to compare our outcomes with these scores.
Corporate Social Responsibility in Credit Unions seen from Carroll Pyramid Model: A qualitative study in Colombia
Authors: López Santamaría Mónica , Grueso Hinestroza Merlin Patricia , Álvarez Rodríguez Juan Fernando
Published: November 2023

One of the main limitations of Carroll Pyramid Model is that it does not consider the differences in the dynamics of each business sector; nor has there been an adequate theoretical justification of the relative relevance of each of the four dimensions that compose it. This study explores the Social Responsibility practices reported by Credit Unions from the Carroll’s Pyramid for a) establishing what type of information (economic, legal, ethical or discretionary) they are privileging in their Social Balance Sheet reports and b) recognizing to what extent there are differences in the way the model is expressed in this economic sector. To accomplish this, a qualitative research study was conducted through a content analysis of the social balance reports of 20 Colombian Credit Unions. The results show that the Carroll’s Pyramid can adopt another type of order in the dimensions that compose it (economic, legal, ethical and discretionary), depending on the economic sector being studied or the type of organization being explored, however, differences found regarding Carroll’s model were not radical as the differences found in other research which found a fully inverted pyramid. These findings pose challenges for cooperative organizations regarding compliance with the 2030 agenda and the mandatory annual report of Social Balance Sheet in Colombia.
Desafíos en la regeneración de grandes grupos cooperativos: un estudio de caso de Mondragon
Authors: Ruiz Aingeru , Bretos Ignacio
Published: November 2023

La literatura previa se ha centrado casi exclusivamente en comprender la degeneración cooperativa, prestando escasa atención al fenómeno de la regeneración, que ha sido abordado fundamentalmente desde un punto de vista teórico. Este artículo proporciona un análisis longitudinal de un proceso regenerativo acometido en el grupo Mondragon, uno de los grupos cooperativos más relevantes e influyentes del mundo. La gran dimensión organizacional y dispersión geográfica que caracterizan a la mayoría de cooperativas de este grupo implica un proceso de regeneración mucho más complejo que el que cabe esperar en cooperativas pequeñas y medianas que operan exclusivamente a nivel local. El marco teórico de la investigación se basa en las tesis de la degeneración y regeneración cooperativa, así como en recientes contribuciones surgidas en torno a la teoría del ciclo de vida de las cooperativas. El estudio muestra los desafíos para reintroducir mecanismos de gobernanza democrática en organizaciones cooperativas de gran tamaño que compiten en mercados globales, así como el efecto de la dispersión geográfica en el declive del sentimiento de pertenencia entre los socios de las cooperativas matrices. Con todo ello, el artículo contribuye a una línea de investigación fundamental centrada en la evolución organizacional de las cooperativas ante un contexto de mercado muy cambiante, competitivo y globalizado.
Recuperar el socialismo. Un debate con Axel Honneth, por José Luis Moreno Pestaña y José Manuel Romero Cuevas (coord.)
Authors: Boix Rodríguez Carlos
Published: November 2023

Ressenya / Reseña / Review
 
Moreno Pestaña, José Luis y Romero Cuevas, José Manuel (coord.) 2022, Recuperar el socialismo. Un debate con Axel Honneth, Madrid: Akal. ISBN 978-84-460-5225-8, 336 páginas
Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1
Authors: Kılıç Ayşe , Halu Arda , Marzio Margherita De , Maiorino Enrico , Duvall Melody G. , Brueggemann Thayse , Rojas Quintero Joselyn J. , Chase Robert , Mirzakhani Hooman , Sungur Ayse Özge , Koepke Janine , Nakano Taiji , Peh Hong Yong , Krishnamoorthy Nandini , Abdulnour Raja-Elie , Georgopoulos Katia , Litonjua Augusto A. , Demay Marie B. , Renz Harald , Levy Bruce D. , Weiss Scott T.
Published: November 2023

Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (1). Vitamin D supplementation studies do not provide insight into the molecular genetic mechanisms of vitamin D mediated immunoregulation. Here we provide evidence for vitamin D regulation of two human chromosomal loci, Chr17q12-21.1 and Chr17q21.2, reliably associated with autoimmune and chronic inflammatory diseases (2–4). We demonstrate increased vitamin D receptor (VDR) expression in mouse lung CD4+ Th2 cells, differential expression of Chr17q12-21.1 and Chr17q21.2 genes in Th2 cells based on vitamin D status and identify the IL-2/Stat5 pathway as a target of vitamin D signaling. Vitamin D deficiency caused severe lung inflammation after allergen challenge in mice that was prevented by long term prenatal vitamin D supplementation. Mechanistically, vitamin D induced the expression of the
Ikzf3
encoded protein Aiolos to suppress IL-2-signaling and ameliorate cytokine production in Th2 cells. These translational findings demonstrate mechanisms for the immune protective effect of vitamin D in allergic lung inflammation with a strong molecular genetic link to the regulation of both Chr17q12-21.1 and Chr17q21.2 genes and suggest further functional studies and interventional strategies for long-term prevention of asthma and other autoimmune disorders.Vitamin D regulates two human chromosomal loci, Chr17q12-21.1 and Chr17q21.2, that are associated with autoimmune and chronic inflammatory diseases.
Single cell multi-omics analysis of chronic myeloid leukemia links cellular heterogeneity to therapy response
Authors: Warfvinge Rebecca , Geironson Ulfsson Linda , Dhapola Parashar , Safi Fatemeh , Sommarin Mikael N.E. , Soneji Shamit , Hjorth-Hansen Henrik , Mustjoki Satu , Richter Johan , Krishna Thakur Ram , Karlsson Göran
Published: November 2023

The advent of tyrosine kinase inhibitors (TKIs) as treatment of chronic myeloid leukemia (CML) is a paradigm in molecularly targeted cancer therapy. Nonetheless, TKI insensitive leukemia stem cells (LSCs) persist in most patients even after years of treatment. The sustained presence, heterogeneity and evolvability of LSCs are imperative for disease progression as well as recurrence during treatment-free remission (TFR). However, dynamic changes among LSC sub-populations upon TKI therapy impede their measurement and targeting. Here, we used cellular indexing of transcriptomes and epitopes by sequencing (CITE-seq) to generate high-resolution single cell multiomics maps from CML patients at diagnosis, retrospectively stratified by BCR::ABL1
IS
(%) following 12 months of TKI therapy as per European LeukemiaNet (ELN) recommendations. Simultaneous measurement of global gene expression profiles together with >40 surface markers from the same cells revealed that each patient harbored a unique composition of stem and progenitor cells at diagnosis demonstrating that cellular heterogeneity is a hallmark of CML. The patients with treatment failure after 12 months of therapy had markedly higher abundance of molecularly defined primitive cells at diagnosis compared to the optimal responders. Furthermore, deconvolution of an independent dataset of CML patient-derived bulk transcriptomes (n=59) into constituent cell populations showed that the proportion of primitive cells versus lineage primed sub-populations significantly connected with the TKI-treatment outcome. The multiomic feature landscape enabled visualization of the primitive fraction as a heterogenous mixture of molecularly distinct Lin
-
CD34
+
CD38
-/low
BCR::ABL1
+
LSCs and BCR::ABL1
-
hematopoietic stem cells (HSCs) in variable ratio across patients and guided their prospective isolation by a combination of CD26 and CD35 cell surface markers. We for the first time show that BCR::ABL1
+
LSCs and BCR::ABL1
-
HSCs can be distinctly separated as CD26
+
CD35
-
and CD26
-
CD35
+
respectively. In addition, we found the relative proportion of CD26
-
CD35
+
HSCs to be higher in optimal responders when compared to treatment failures, at diagnosis as well as following 3 months of TKI therapy, and that the LSC/HSC ratio was increased in patients with prospective treatment failure. Collectively, the patient-specific cellular heterogeneity multiomics maps build a framework towards understanding therapy response and adapting treatment by devising strategies that either extinguish TKI-insensitive LSCs or engage the immune effectors to suppress the residual leukemogenic cells.
The catalytic mechanism of the RNA methyltransferase METTL3
Authors: Corbeski Ivan , Vargas-Rosales Pablo Andrés , Bedi Rajiv Kumar , Deng Jiahua , Coelho Dylan , Braud Emmanuelle , Iannazzo Laura , Li Yaozong , Huang Danzhi , Ethève-Quelquejeu Mélanie , Cui Qiang , Caflisch Amedeo
Published: November 2023

The complex of methyltransferase-like proteins 3 and 14 (METTL3-14) is the major enzyme that deposits N6-methyladenosine (m
6
A) modifications on mRNA in humans. METTL3-14 plays key roles in various biological processes through its methyltransferase (MTase) activity. However, little is known about its substrate recognition and methyl transfer mechanism from its cofactor and methyl donor S-adenosylmethionine (SAM). Here, we study the MTase mechanism of METTL3-14 by a combined experimental and multiscale simulation approach using bisubstrate analogues (BAs), conjugates of a SAM-like moiety connected to the N
6
-atom of adenosine. Molecular dynamics simulations based on crystal structures of METTL3-14 with BAs suggest that the Y406 side chain of METTL3 is involved in the recruitment of adenosine and release of m
6
A. A crystal structure representing the transition state of methyl transfer shows a direct involvement of the METTL3 side chains E481 and K513 in adenosine binding which is supported by mutational analysis. Quantum mechanics/molecular mechanics (QM/MM) free energy calculations indicate that methyl transfer occurs without prior deprotonation of adenosine-N
6
. Furthermore, the QM/MM calculations provide further support for the role of electrostatic contributions of E481 and K513 to catalysis. The multidisciplinary approach used here sheds light on the (co)substrate binding mechanism, catalytic step, and (co)product release catalysed by METTL3, and suggests that the latter step is rate-limiting. The atomistic information on the substrate binding and methyl transfer reaction of METTL3 can be useful for understanding the mechanisms of other RNA MTases and for the design of transition state analogues as their inhibitors.
«Lutefiskens lengsel mot havet»
Authors: Andersen Hadle Oftedal
Published: November 2023

I denne artikkelen undersøker eg skjønnlitterære tekstar av tre sentrale forfattarar knytte til tidsskriftet Profil på 1960-talet: Dag Solstad, Einar Økland og Jan Erik Vold. Dei tekstane eg fokuserer på, er alle kjenneteikna ved at dei er humoristiske, og at dei på ulike måtar nyttar denne humoren til å kritisera andre lyriske skrivemåtar enn den som kjenneteiknar Profil-gruppa sin eigen poetikk. Nærmare bestemt handlar det om kritikk av den idealistiske tradisjonen; kritikk av den moraliserande litteraturen; kritikk av nasjonalromantikken; kritikk av særlege, poetiske motivkrinsar; kritikk av symbolbruk; og kritikk av høgstemd, poetisk særspråk. Saman med analysane av Profil-forfattarane sine tekstar, går eg inn på døme på desse kritiserte skrivemåtane, av Paal Brekke, Arnulf Øverland, Erling Christie, Tore Ørjasæter og A.O. Vinje. Og eg peikar på to internasjonale inspirasjonskjelder, Werner Aspenström og Lewis Carroll. Det overgripande poenget er at Profil-forfattarane ikkje fokuserer på éin hovudmotstandar, men femner særs vidt i sin humoristisk-kritiske omgang med tradisjonen.
Humor i fortellingene om Buster Oregon Mortensen
Authors: Takle Cecilie
Published: November 2023

Denne artikkelen undersøker humor i tre ulike versjoner av fortellinga om Buster Oregon Mortensen fra 1979, 1984 og 2021. Jeg gjør en komparativ analyse i form av en tematisk nærlesning av de tre verkene med et spesielt blikk på humor i relasjon til maktbalanser og til temaer som oppleves som vanskelige eller tabubelagte.
Ett Sverige i miniatyr, ett Sverige i skrattspegel. Slyngstad Events som senfolkhemsk samhällssatir
Authors: Żmuda-Trzebiatowska Magdalena
Published: November 2023

Romanen Slyngstad Events (2002) av Unni Drougge kan klassificeras som skröna, det vill säga uppdiktad, humoristisk berättelse som för det mesta ska underhålla. Parallellt innehåller boken en hel del samtidskritik. Åsabygden, ett fiktivt område i Skåne där handlingen är förlagd, drabbas av samma problem som det senmoderna svenska välfärdssamhället i stort och kan betraktas som ett Sverige i miniatyr. Genom att analysera romanens starka och utrycksfulla karaktärer vill jag visa att romanen inte endast är en underhållande skröna utan den kan betraktas som en samhällssatir där de enskilda aktörerna representarar olika levnadssätt och värderingar, men framförallt olika svagheter och brister hos medborgare i välfärdsstaten. I vidare mening framstår Slyngstad Events också som en berättelse om ett Sverige som inte längre är ett lyckligt folkhem och ett mönsterland utan håller på att förvandlas till sin motsats, ett bisarrt monsterland, vilket jag utvecklar genom att tolka romanen mot bakgrund av de olika historiska berättelserna om folkhemmet.
Prevalence of Temporomandibular Joint Pain among Patients who Reported to Dental OPD at a Tertiary Hospital in Pondicherry, India: A Cross-sectional Study
Authors: Ramachandran Sajani , Ravichandran K
Published: November 2023

Introduction: Temporomandibular Joint Disorder (TMJD) is a debilitating condition that affects the quality of a person’s life. However, its aetiology remains controversial. Understanding the signs and symptoms associated with this condition is crucial for better comprehension. Determining the prevalence of TMJD can emphasise the importance of routine Temporomandibular Joint (TMJ) examinations and the implementation of preventive measures. Aim: To determine the prevalence of TMJ pain among patients who reported to the dental Outpatient Department (OPD) between January 2015 and December 2019. Additionally, the study sought to identify potential predisposing factors for TMJ pain. Materials and Methods: A cross-sectional study was conducted in the Dental Department at Pondicherry Institute of Medical Sciences, Pondicherry, India. The study duration was six months, from December 2021 to May 2022. The study was done by examining the medical records of all patients who reported TMJ pain during the specified period. A total of 32,094 patients’ records were reviewed, and 322 patients reported pain in the TMJ region. The patients’ reported signs and symptoms were extracted from their case records and evaluated. Pearson’s Chi-square/Fisher’s-exact test was utilised to determine associations between the factors. Results: The mean age of the participants was 35.4±13.2 years. Out of the 32,094 patients who attended the dental OPD, 327 (1.02%; 95% CI: 0.91-1.13) reported TMJ pain. Among these patients, 207 (63.3%) were females. Joint sounds were the most common symptom, observed in 243 (74.3%) patients, followed by emotional stress or tension, reported by 205 (62.7%) patients. Most symptoms were more prevalent in females than males. Parafunctional habits and stress/tension showed a statistically significant association (p<0.001) with male gender. Additionally, occlusal variation, joint sound, missing teeth, chewing with one side, parafunctional habits, and stress showed associations with age. Conclusion: The TMJ pain was more frequently reported by women than men in the studied population. The most common symptoms reported were pain and joint sounds. The highest number of patients fell within the 30 years-55 years age group. Although the prevalence identified was 1.02%, routine TMJ examination should be conducted as a standard part of oral and maxillofacial examinations to identify any predisposing factors that may lead to TMJD in the future.
Comparison of Dexamethasone Implant and Anti-VEGF Agents in the Treatment of Naive Diabetic Macular Oedema: A Prospective Cohort Study
Authors: Iyer Vanaja , Mohanty Gayatree , Lalitha CS , Das Manmath Kumar , Mehak Sethi Mehak Sethi
Published: November 2023

Introduction: Diabetic Retinopathy (DR) is one of the common microvascular complications of diabetes. In patients with DR, the most frequent cause of vision loss is Diabetic Macular oedema (DME). In the present era, anti-Vascular Endothelial Growth Factor (anti-VEGF) agents are the mainstay of treatment for managing DME. A majority of patients show a good response to multiple doses of these agents administered by a pro re nata regimen at regularly spaced fixed intervals. However, the tendency of DME to become chronic and resistant to these agents, as well as the burden of repeated injections, necessitates considering alternative treatment options with similar or better efficacy. As steroids can address these drawbacks of anti-VEGF treatment, the present study compared the efficacy of anti-VEGF agents with dexamethasone implant in the treatment of naïve DME. Aim: To compare the effectiveness of dexamethasone implant with anti-VEGF agents in the treatment of naïve DME. Materials and Methods: A prospective cohort study was conducted in the Department of Ophthalmology at Kalinga Institute of Medical Sciences and Pradyumna Bal Memorial Hospital, Bhubaneswar, Odisha, India from September 2020 to September 2022. A total of 100 eyes with DME, newly diagnosed patients aged 18 years and above, without other macular oedema-causing diseases, were included. A total of 50 eyes in each group were treated with an anti-VEGF agent (Group A) or dexamethasone implant (Group B), and Best Corrected Visual Acuity (BCVA) and Central Foveal Thickness (CFT) were monitored for six months. For statistical analysis, paired t-test and independent t-test were used for within-group and inter-group analysis, respectively. A p-value <0.05 was considered statistically significant. Results: In both groups, post-treatment BCVA showed marked improvement, but there was no significant difference in mean BCVA between the groups (p=0.89) at six months. However, the mean CFT showed significant improvement in Group B at six months. In Group A, the mean CFT reduced from 441.87±54.48 μm to 257.83±25.73 μm, and in Group B, the mean CFT reduced from 464±109.44 μm to 207±22.51 μm at six months (p<0.0001). Adverse events like cataracts and glaucoma were seen in patients treated with the dexamethasone implant and were managed by cataract surgery and topical anti-glaucoma medications, respectively. Conclusion: Dexamethasone implant and anti-VEGF agents are equally effective in improving visual acuity; however, dexamethasone stands superior in reducing macular thickness. Needing fewer injections while treating with a dexamethasone implant improves compliance. The progression of cataract remains a major side-effect with the dexamethasone implant, which is not a concern when treating DME in pseudophakic eyes.
President Biden’s Executive Order on Artificial Intelligence—Implications for Health Care Organizations
Authors: Mello Michelle M. , Shah Nigam H. , Char Danton S.
Published: November 2023

This Viewpoint discusses a recent executive order by US President Joe Biden about the development and implementation of AI, including the role of government vs the private sector and how the order may affect health care.
The Worsening Problem of Food Insecurity
Authors: Bleich Sara N. , Koma J. Wyatt , Jernigan Valarie Blue Bird
Published: November 2023

This JAMA Forum discusses disparities and food insecurity among underserved populations in the US, the actions being taken by states, tribal actions, and additional steps to ensure food and nutrition security.